wanglab/gogpt-training-data huggingface dataset:
Protein: Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12) (Q9CWU0)
Organism: Mus musculus (Mouse)
Function: Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.
Interaction partners:
- piRNA biogenesis protein EXD1
- Piwi-like protein 2
- Tudor domain-containing protein 1
- RNA helicase Mov10l1
- ATP-dependent RNA helicase DDX4
- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
- ATP-dependent RNA helicase TDRD9
- Tudor domain-containing protein 5
- Inactive peptidyl-prolyl cis-trans isomerase FKBP6
- Tudor and KH domain-containing protein
Sequence:
MFEVLVLKIEDPGCFWVIIKGCSHFLEQEVDYQKLNTAMNDFYNSMCQDVEMKPLMLEEGQVCVVYCQELKCWCRALIKSIISSADHYLAECFLVDFAKYIPVKSKNIRVAVESFMQLPYRAKKFRLYGTKPVTLHIDFCEDNAEIVPATKWDSAAIQYFQNLLRATTQVEAKLCAVEEDTFEVYLYATIKNEKVCVNDDLVAKNFAYYVSPMGNKNLNPLEKPRQSLNSVTCSSKLSPSLTLWPMLLQGKDYHRMENKALNYKDSLTDSPKMMLEKQQQSLPLKHTEKCTESSVYWPTKRGITIYADPDVPSVSGSSQRPNEKPLRLTEKKDCDEKNGCVKLLQFLNPDPLRADGTSDLHQLQKVKLGTLQPGVVLRNRIEPCLTLEKSPLSADLKKMALTCLNSDTEDMKVAMEEMIPPEALQRNKFPGPSHTASYSWPPIARGCDMVVISHCGNDPLLYLPPLLTILQMGGCYKSLPSRNGPLAVIVCPGWKKAQFIFELLGDYSMSSRPLHPVLLTIGLHKDEAKNMKLPRGCDVIVTTPHSLLRLLTYRSLLFLRLCHLVLDEVHMLFFEANEQMFAILDNFKKNVEVEERESAPHQIVAVGVHWNKHIDHLVREFMKDPCVVITALEEAALYGSVQQVVHLCLECEKTSTLLQVLDFVPSQAQKTLIFTCSVAETETVCKGSPAEQGDKKTKSVLLLTERNASHAVGILRYLERADAKIPSELYEFTAGVLEAKEDKKARRPLCPYLKAFGFCKDKRICPDRHHINPEMDIPRKLSNKTLPVFGHIRVIPFYISNATNYFGRIIDKHVDLYETLNAEMNEYFKESSNKTSAEKVENLGLYGLEEKTLFQRVQVLEVSQKEDTWGLGSILVKLIDEGRTKLITRDQLLLLPEKFHTLPPQAVEFIVCRVKPADSEIEWNPKVTRYIHHKIVGKMHDAKVVLALGNTLWIDPMVHVTKLSNLKTSIIDYNVRAEILSMGMGIDNSEHLEQLKKLYKEAKLPAFEDLPCQTSIPTTVEDTVCLQGTQQGDGGTERGAGSQEDSDNQKPGVLSEDIGSETISSAPQPHGRSFHPQIKWFQKDDVVILKIKIRNVKDYKCKFFTDRVIFSAWVGDKFYLADLELQGDIRKDDCKCIIKDDEPLITLAKEKQECWCGLLKQRNPNVAFDFDHWEECEEDSPFSKVVNSKNLSCKVAALAESSGSSSDTTDGSESE
Protein: Phospholipid phosphatase 2 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c) (Q8K593)
Organism: Rattus norvegicus (Rat)
Function: Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (By similarity). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity.
Subcellular location: Membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- phosphatidate phosphatase
- phosphatidate phosphatase
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- phosphatidate phosphatase
- Diacylglycerol O-acyltransferase 1
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- Diacylglycerol O-acyltransferase 2
- Sphingosine-1-phosphate phosphatase 2.
- Sphingosine-1-phosphate phosphatase 1
- Cholinephosphotransferase 1
Sequence:
MERRWVFVLLDVLCVLVASLPFIILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVIITATVVLVSSGEAYLVYTDRLYSRSDFNNYVAAIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVEVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTVCYVSDFFKSRPPQSCQENEESERKPSLSLTLTLGDRP
Protein: Probable transcription factor At1g61730 (Storekeeper-like protein At1g61730) (Q9SYA9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Zinc finger CCCH domain-containing protein 21
- Zinc finger CCCH domain-containing protein 17
- Glycine-rich RNA-binding protein 2, mitochondrial
- Basic transcription factor 3
- Protein HLB1
Sequence:
MTKKLNPLEDPPTATSSDEDDVETSEAGEASDDSSSSEEDVPIKIRIKSPSATTAAAPPAKSTAVSTAADSDSGSETETDSDSESTNPPNSGSGKTIALNTVNLKKKEDPTSSSATLALPAMKSGTKRPASEAAATTSTKRVKKDEESVKKPGGFQRLWSEEDEILVLQGMIDFKADTGKSPYVDTNAFYDFLKKSISFEVSKNQFMDKIRSLRKKYIGKEGRNEPSFVKAHDKKAFELSKFIWGPKGIALDSNVKSNGVSKKSVAKKKIDSVKQELVFAGGSSTNGKKVEEDGGDDGCDWFDNSSLVRMIASLGVDEYYVKQQWSLVSVESKKIVEEKYKLLQAKELEFVLEKTKFLNEVASMFVEASKNKPLDT
Protein: Possible conserved membrane protein (P96258)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Serine/threonine-protein kinase PknG
- Probable glutamine-binding lipoprotein GlnH
Sequence:
MTVELAHPSTEPLGSRSPAEPAHPRRWFISTTPGRIMTIGIVLAALGVASAFATSTTIEHRQQVLTAVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAQAEPGGVRLRYEQAITDASVAVTRASSGLTDESLVQLLGRINAELAVYTGLVEIARANNRAGNPVGSSYLSEASGLMQSTILPDAQRLYQATSARVDRETTASTQIPAPVILVVATTVVFGAFAHRWLARRTRRRINPGLVVGALGILVMVVWVGTALTISTTASRSAKDTAAESLKTITNLAITAQQARADETLSLIRRGDEEVRKQAFYQRIDAMQRQLNDYMARRHAVDKPDLQGADQLLVRWRQANDRINSDISVGNYRAATQVALGKGEDDATPAFDKLDEALTKAMGQSRTQLRHDILNAHRGLAGAQVGGVVLSLGAAIAVALGLWPRLKEYR
Protein: Protein kinase C (EC 2.7.11.13) (A0A2R8QIY5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004318}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004318}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
- Phosphoinositide phospholipase C.
- Serine/threonine-protein kinase TOR
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase
- Phospholipase C, epsilon 1.
- Raf-1 proto-oncogene, serine/threonine kinase b.
- Raf-1 proto-oncogene, serine/threonine kinase a.
- Protein kinase C
- Protein tyrosine kinase 2ab
Sequence:
MADTQSNEQSSSDVANRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHELVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDSCDMNVHKQCVMNVPSLCGTDHTERRGRLYMKIEVIGDKMHVTVGEGKNLIPMDPNGLSDPYVKLKLIPDPKNETKQKTKTIRSSLNPTWNETFTFKLKPADKDRRLAVEVWDWDRTTRNDFMGSMSFGVSELMKSPVCGWYKMLNQEEGEYYNVPIPDEDDPDTELRQKFEIAKLGPPKKNITALDDSGSSITSSNVDNVRLSDFNFLAVLGKGSFGKVMLAEMKSSDELFAIKILKKDVVIQDDDVECTMVEKRVLAQQDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEIAVGLFFLHKKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENIVEGVTTRTFCGTPDYIAPEIIAYQPYGRSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYSKTLSKEAVSICKGLMTKHPSKRLGCGQEGERDIREHAFFRRIDWDRLANREVQPPFKPKVCGKGAENFDKFFTRTQPQLTPPDELVIANIDQADFDGFTFVNPQFVHPSLVNTE
Protein: Putative PRXamide receptor (Q8ITD0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLPTNSSGVLATDLQLFHNEKFLLNLTQVLNISADNLTSLLQGLEPEELLPTVTPMTPLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMHTATNFYLFNLAISDMILLCSGMPQDLYNLWHPDNYPFSDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALPQAIQFSVVMQGMGTSCTMKNDFFAHVFAVSGFLFFGGPMTAICVLYVLIGVKLKRSRLLQALPRRCYDVNRGISAQTRVIRMLVAVAVAFFICWAPFHAQRLMAVYGSTSGIESQWFNDVFSILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKVTLARHFGLGGKNQGRGLPHTYSALRRNQTGSLRLHTTDSVRTTMTSMATTTTGLNGSANGSGNGTTTGQSVRLNRVSLDSVQMQGQNRSRQDLFDNPRRMLQTQISQLSSVGDAHSLLEEDLQFPGEPLQRQPTMCSIDELTDDLAISRSRLKLTRITRPPGGVTGGVAGGSKTVAAGSGGVSGDESSGKVRKAKVKVLKSSSPFKGLRTKFNWRARRKGSHKPHEKGATVNGGDTEERAAF
Protein: Nucleoside phosphorylase, putative (EC 2.4.2.-) (Q57VZ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cytidine deaminase, putative
- SUMO-conjugating enzyme UBC9
- S-methyl-5'-thioadenosine phosphorylase
Sequence:
MAASANGSTKGSETDLPIGKDGTTLHLKCKSDELADRIIFVGDPGRVDVISGYFDKDSIRASRDHREIRFATGTYKGTPVTVISTGMGVDNIEIVLNEIHALKEYDMERGQWRHRKGDADAPSAGPFFDPSTMKIIRLGTCGSPAESVPPLALAVTRHAIGMDNTSLYYSAGTRETSKDQQEIRRIVREQTGLRAIDIYTSMAHPNITKSICAACDAHNAATGSEADKQQYVIGTTATASGFYGCQGRRVGRFMKHLTVPNMVEELGSLKFNLSNGVEVVTNIEMETSAICYLSDMLGYQAGAACVVVSKRVGEKKMFLGDQLDAAMKRCIKIILEALVSA
Protein: Prefoldin subunit 3 (Q8T965)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Probable prefoldin subunit 5
- Probable prefoldin subunit 6
- Probable prefoldin subunit 2
- Probable prefoldin subunit 4
- GEO07746p1
- LD43819p
- T-complex protein 1 subunit alpha
- GEO12025p1
- LP10147p
- T-complex protein 1 subunit delta
Sequence:
MFAFIDTIKKPPLGGRKSFMPIPEAKLVDDVVSYIAKPEFYSTVPAALKMQRLFYVQYSELAAKLETDLTAVLTRLEAAKNNLELVRRFIDNPDKEVHSLVQIAQGVFRWVSIPPVQKVTLQVGASLQMEFELSEAEEFIKKDITSLVKQQLQHEHDIDYLQDQVNTIEMNLAVLYKHEVEN
Protein: Virion protein G52 (D0U1P1)
Organism: Wood mouse herpesvirus
Interaction partners:
Sequence:
MASKKPDKTYEEMVKEVERLKLENKSLKQKVKSSGAVPSDDSILTAAKRESIIVSSSRALGAVASRKIEAKVRSRAAKAVTEQELTTMLQSLTLRVDVSMEETTMGATGGIGPSSNTETKKRKPRSKSRHRHDHE
Protein: Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110) (Q86TL2)
Organism: Homo sapiens (Human)
Function: Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}; Multi-pass membrane protein {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}. Note=Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells (PubMed:26644574). May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells (Probable). {ECO:0000269|PubMed:26644574, ECO:0000305|PubMed:26322679}.
Interaction partners:
- Store-operated calcium entry-associated regulatory factor
- Musculoskeletal embryonic nuclear protein 1
- Calcium release-activated calcium channel protein 1
- EF-hand calcium-binding domain-containing protein 4B
Sequence:
MQGPAGNASRGLPGGPPSTVASGAGRCESGALMHSFGIFLQGLLGVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPV
Protein: LD34623p (Q95RF4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAHAKNFKRIKSMLPRRESERRNHILSRHSDILTSIETRISMLTMTYSKFIDLNICCFIPGRVLDEINSILRILSTSTKQLRPHEVLQELRDISSMAIEHFDEKIAVNFKLEHRKQLAESTAAGARLVVCSALGDISFSGVRRTGISRPVDHGLVQQAIVQLAPISASKSHSDSSQKDRMSKQLFKQYQLQRSLSQKIRLLEVSRKVQDRRLQEALSSITELTTQVSELKRQMEDVVANMPSCAVKRQAVASADCLPPALKKPKV
Protein: ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) (Q8AYP9)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03184}.
Interaction partners:
Sequence:
MAGAGMAIAVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGDNIKQATWLSVSNIIQLGGTVIGSARCKAFTTRQGRCAPARNLVEHGITNLCVIGGDGSLTGADVFRAEWAGLLDELLRDGLISEEVAKANGRLNVVGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLASGADWLFIPESPPEDGWEDLMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSNYVKDLVVQRLGFDTRVTVLGHVQRVGTPSAFDRVLSSKMGMEAVMALLEATPDTPACVVSLSGNQSVRLPLMECVQVTKDVQKAMDEKRFDEAIQLRGRSFENNWNIYKLLAHQKPAQEKSPFSLAILNVGAPAAGMNAAVRSAVRISICRGHTIYAVSDGFEGLAKGQIREVGWHDVAGWLGRGGSMLGTKRTLPKTCMEKIVENVRKFNIQGLLVIGGFEAYEGVLQLVEARGQYEELCIIMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTTRRVFIVETMGGYCGYLCTVTGIAVGADAAYVYEDPFTIHDLKANVEHLTDKMKTDIQRGLVLRNEKCHEHYTTEFLYNLYSSEGKGIFDCRINVLGHLQQGGAPTPFDRNYGTKLGVKAVLWMSEKLQEAYRKGRVFANSADSACVIGLRKKVVAFSPVTELKKVTDFEHRLPQEQWWLNLRLMLKMLANYQISLTEYISGKMEHVTRRTLSIEKGF
Protein: LD47721p (Q95RA7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRSHSAGLKLFKTHLIEISLNFQPPCKKTLARMASLPVILQCRICLGDFEESQMICLFGDKGESDLRKKLELCCRIRVRQSPQLPEKACNSCCEFVQMWFNFRQMCLNSQVYWETSSSERPEALAQASDAEYMLYLYENLHLKLGTENQEKEEITAIEEGDEQQEDQSQEVLDFNGFIINESIEEDEEPNTESPEQILISHMDSYVDDQQMEELIDDKGELVEELSNANTFYEVEYGDEELLMSSAPSPHPSFKMDKQKPGRPRKPDAELKFKRKDINAKERGNQPKCKEEEKFMCILCGNVFYKKSVFTAHMMTHSEYKPHQCEICNKSFRQMGELRAHIRRHTGDRPYKCMYCDRHFYDRSERVRHERVHTNTRPYACQECGKTFTHTAILKNHILSHSAQKNYNCGICCKSFTLLHQLKAHLQTLTHRNKMEQTIPSSPEMLES
Protein: Guanine nucleotide-binding protein subunit gamma 2 (Ggamma-subunit 2) (Heterotrimeric G protein gamma-subunit 2) (Q6YXX9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15078334}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta
- Guanine nucleotide-binding protein alpha-1 subunit
- Guanine nucleotide-binding protein subunit gamma 4
Sequence:
MRGEANGEEEQQPPRRNHLRDDAEEEEEVERRAARPVSGQQQQQQRRRPTDVGGGAAMRSVGYVGKHRLSAAIARLDQELQSLQDELNELETMEPASAACQGVITSTEGKSDPLLPVTIGPENASWERWFQRVRSSRSNKWWASKGSDFS
Protein: BHLH transcription factor-like protein (Q8L4Y9)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MARGAAGGEVGRSMPAVHDAHDDSENFLELLNSRTLAPELFAEPPACDYLKKMEYGGGGGGGGGGWPEHQFTAAAALEKHLSSAAAAGYGGALAHHHHAAGAPERLTANLSDLVSNWSIAPPNHGHHVGGAAACDNPAVAAAMAAAHGGGNVKQSGSSFLDSGGGGGGAMLQQESSSSTGTGGGGQDFLRPMGLAAGSSSYSSMLGLSSRMYGGGGTATMDVPWGSSNAGAARSLSDLISFGGGAMDKPPPPPPSSAPARTSSADYKKQQGQQEISSPVKTSSSGGGGKEGKKKRSEEAAGSEGSTKKSKHEATSPTSSLKVPKVKLGDKITALQQIVSPFGKTDTASVLYEAINYIKWLHEQVQLLSDPYMKSSSSKDYNAWGGLDRKEKADAEVDLRSRGLCLVPVSCTPQVYRDNNGPDYWTPPYRSCLYR
Protein: Vacuolar protein sorting-associated protein 8 (Vacuolar protein-targeting protein 8) (P39702)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for localization and recycling of the CPY sorting receptor (VPS10) to the late-Golgi compartment. Involved in the retention of proteins to the late-Golgi. Plays an integral role in the complex vacuolar protein sorting process.
Subcellular location: Golgi apparatus, Golgi stack. Note=Associated with the late-Golgi membranes.
Interaction partners:
- Vacuolar protein sorting-associated protein 16
- Vacuolar protein sorting-associated protein 33
- Vacuolar protein sorting-associated protein 3
- Vacuolar morphogenesis protein 6
- Vacuolar protein sorting-associated protein 21
- Vacuolar membrane protein PEP3
- E3 ubiquitin-protein ligase PEP5
- GTP-binding protein YPT52
- Vacuolar protein sorting-associated protein 41
- Vacuolar protein sorting-associated protein 9
Sequence:
MEQNGLDHDSRSSIDTTINDTQKTFLEFRSYTQLSEKLASSSSYTAPPLNEDGPKGVASAVSQGSESVVSWTTLTHVYSILGAYGGPTCLYPTATYFLMGTSKGCVLIFNYNEHLQTILVPTLSEDPSIHSIRSPVKSIVICSDGTHVAASYETGNICIWNLNVGYRVKPTSEPTNGMTPTPALPAVLHIDDHVNKEITGLDFFGARHTALIVSDRTGKVSLYNGYRRGFWQLVYNSKKILDVNSSKEKLIRSKLSPLISREKISTNLLSVLTTTHFALILLSPHVSLMFQETVEPSVQNSLVVNSSISWTQNCSRVAYSVNNKISVISISSSDFNVQSASHSPEFAESILSIQWIDQLLLGVLTISHQFLVLHPQHDFKILLRLDFLIHDLMIPPNKYFVISRRSFYLLTNYSFKIGKFVSWSDITLRHILKGDYLGALEFIESLLQPYCPLANLLKLDNNTEERTKQLMEPFYNLSLAALRFLIKKDNADYNRVYQLLMVVVRVLQQSSKKLDSIPSLDVFLEQGLEFFELKDNAVYFEVVANIVAQGSVTSISPVLFRSIIDYYAKEENLKVIEDLIIMLNPTTLDVDLAVKLCQKYNLFDLLIYIWNKIFDDYQTPVVDLIYRISNQSEKCVIFNGPQVPPETTIFDYVTYILTGRQYPQNLSISPSDKCSKIQRELSAFIFSGFSIKWPSNSNHKLYICENPEEEPAFPYFHLLLKSNPSRFLAMLNEVFEASLFNDDNDMVASVGEAELVSRQYVIDLLLDAMKDTGNSDNIRVLVAIFIATSISKYPQFIKVSNQALDCVVNTICSSRVQGIYEISQIALESLLPYYHSRTTENFILELKEKNFNKVLFHIYKSENKYASALSLILETKDIEKEYNTDIVSITDYILKKCPPGSLECGKVTEVIETNFDLLLSRIGIEKCVTIFSDFDYNLHQEILEVKNEETQQKYLDKLFSTPNINNKVDKRLRNLHIELNCKYKSKREMILWLNGTVLSNAESLQILDLLNQDSNFEAAAIIHERLESFNLAVRDLLSFIEQCLNEGKTNISTLLESLRRAFDDCNSAGTEKKSCWILLITFLITLYGKYPSHDERKDLCNKLLQEAFLGLVRSKSSSQKDSGGEFWEIMSSVLEHQDVILMKVQDLKQLLLNVFNTYKLERSLSELIQKIIEDSSQDLVQQYRKFLSEGWSIHTDDCEICGKKIWGAGLDPLLFLAWENVQRHQDMISVDLKTPLVIFKCHHGFHQTCLENLAQKPDEYSCLICQTESNPKIV
Protein: DUF229 domain containing protein (Q9W0F7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Seminal fluid protein 38D
- Seminal fluid protein
- GH23626p
- Accessory gland protein Acp29AB
- ACP53C14B
- SCP domain-containing protein
- Aquarius
Sequence:
MSLGRNVFLLCSIQFLLCKAKLSLHSHYPNVAKTLENKKFYVDSPSCKMPEMDPFSADIMRFFKRRQFRECSSDKDLLISEFDSHLRQYRIKIDENSAQQHLKKFGNATLKCEYQVIGRNKKDSFPDNHFSFSKLQPLSQSFLVPKTIDFISTQCHAVHGNIDLKLLQKDAFLFVQDRLNHEHKNTEHHRPDLQSKPNVIILGIDSTSRMNLRRSMPKVHKFLQRPGWFEMQGYNKVGENTLPNLLAILTGNAEENALFNGRFGHSGFIDKLKFIWQLFKKNGYMTAFGEDCAKINTFNYQKPGFKQQPVDFYLRNFIVALETILKTRREFGNVFCLGRKLGFQYVFDFARQFMQRFENSAPVFGIFWSNSFTHEDFLGATALDHVFLEYLTLYDELGFFNRSIVMVLSDHGYRYGVTRQASKSGYLEERLPLMFIHVPPWFRKIYPQYVENLKINQNRLSSGFDLHMTLHHLLHLNATSMADFSPKLQASQCKMCQSLFFQLPANRNCSHAGIREKWCSCEPTETVTNQRLLRKVAQEVVHHMNRHLRDRNLTTLCQNYALKKVLYLDSKISLSEDSVEDEQLHTYIITFETNPSSAHFEATVQWNSEKETLNMNVDELSRLESYEKHSKCTRDPIIKKYCICKEFK
Protein: Pannexin-3 (Q8CEG0)
Organism: Mus musculus (Mouse)
Function: Structural component of the gap junctions and the hemichannels.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21690309}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21690309}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}.
Interaction partners:
Sequence:
MSLAHTAAEYMLSDALLPDRRGSRLKGLRLELPLDKMVKFITVGFPLLLMSLAFAQEFSSGSPISCFSPSNFSVRQAAYVDSSCWDSLAHHTQDKAGQYKVKSLWPHKALPYSLLALAVAMYLPVLLWQYVAVPSLSSDLLFIISELDKSYNRSIRLVQHMLQIRQSSSDPHVFWDELEKARKERYFEFPLLERYLECKQRSHWLVATYLLRNALLLLFTSATYLYLGQFHLDVFFQDEFNCFIKTGLLHDETHVPELITCRLTSLSVFQIVSVSSAAIYTILVPVIIYNLTRLCRWDKGLLSIYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLSVLKDTTTQKHNIDTVVDFMTFVAGLEPSKPKHLTQHTYDEHA
Protein: Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Heat shock protein family B member 3) (Protein 3) (Q12988)
Organism: Homo sapiens (Human)
Function: Inhibitor of actin polymerization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus {ECO:0000269|PubMed:19464326}. Note=Translocates to nuclear foci during heat shock.
Interaction partners:
- Insulin-like growth factor 1
- Insulin
- Cytochrome c
- Apoptosis regulator Bcl-2
- Heat shock 70 kDa protein 4
- Insulin-like growth factor 2
- Heat shock protein beta-2
- Plectin
- RAC-alpha serine/threonine-protein kinase
- Heat shock protein HSP 90-beta
Sequence:
MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK
Protein: RNA-binding protein, putative (Q38F87)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYFPRHQHEKEPRGRFNPQALDWLPGMVQMATLPPAPVATYPQHFPSVHYNNMTDGPATLPCFPDLFRDWLHGGVMFPPFPFAGGPSDGAYYPTGPQHPQLCPQSAEGWMEAEQRYYKYFHPFWCAYQRFLRDCYTRPVTNDLYSAVPTSHQTQPPAVATADIATFTREGTPWTQNWGCDAQHKENTVSNKCDSCVKLAAPTHAGGEVLPGDCETTAGEWREISSLALSSCLLCGDTGHRYTACRFFDGKTLCLVHIADSYIYAMHHKNWVEKATLLDVCSFVHVAVGILPKNLLLYIGDHVLDVTSYETDARCCDLDLLPGAVVGVATRHEAVPEMESKGPAEQFSEPRVEDQCLKVSPISKASASSTSLHTSETQEGLLGRNESREGDNNESPGVDDIEADRRKADAVRQRQSPVAAPYLGTTDGDLNSTQTRAQQQTASIPTCDRPEPQGGLEGKACDEIESHNDIVDSAQGEEVSDAPVESNGKTESDGRRRRTVHVRFIPVSMAFSDIRALLWSCGEVYKVRLVKPKTTPNPDKMFYVCFVEYAEEQAALKMLEMHGHRIAASFHLAVEISKHAILGGYVTDRDVGTGKPCTFGLTDTERWAIEQRHKRPGAGSAGSGNGECAEEGGYEGEGKGGRRCRRGGRKHRGRARQSTPTSGETPNGLGEAGKQCTGGPYSLQIVAEDSKRKSCRGSHRITDAKSGNGTTGAVGELPQTTLANSDLSTKPIQSTVSTPREVVGHISVTAEESKLLEHLRNATISYLRCPSKRSFYEVLTVLEDVKLCSPSPLCCLHLTKAEVALLFLHRSSGFVEAAATAANGAVRAGEELSHLMARDASSQDHIGASWSSFFTASHPSLCGHWKNWRDMVYGDEEESGEGSRNTKSDGGTATASYPRVGRVLCFVESLLHIALLCDSLLMHELEKDCEGKFVMRNIDADSPGVGKVMWKLVCCIRRLLQRLRAFATESDGSGREDRTVLSPRWLTTVARVLVLLPSEAEWHVGNLLDAFVPCASDLPVAILEDLAGIRLF
Protein: Troponin I protein (Q704P7)
Organism: Lethocerus indicus (Giant water bug)
Interaction partners:
Sequence:
MADEEAKKAKQAEIERKRAEVRKRMEEASKAKKAKKGFMTPERKKKLRLLLRKKAAEELKKEQERKAAERRRIIEERCGHCCDVDNANEDDLHEVIQHYYDRMYTCESQKWDLEYEVRKRDLEISDLNSQVNDLRGKFVKPTLKKVSKYENKFAKLQKKAAEFNFRNQLKVVKKKEFTMEEEEKEKKVVDWSKKDEKKVDEEAVVNSDVAELSSVQESVSQEAPPVDTQSEASEIPTTTTQEEHKQEEQQQQQQPPPPPKTEDDLWLFLKEAITSANPMTLEELQQKLIDTVSHVPPDFLEPVVEASIKRSQSMDQLASISSEVAEGGPPAEPGKEGEAAPPAEGAPAAAPPAEGAPPAEGTPAAAAPPAEGAPAAAAPPAEGAPPAEGAAPAAAPPAEGAPAAAAPPAEGAPAAAAPPAEGAQAAAAPPAEGAPAAGAPPAEGAPPAAAAPPAEGAAPPAEGAAAPAPAIQPVDAPPQVQAAA
Protein: Aquaporin 10 (Aquaporin-10a) (Q6DHQ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKRMKVKNELARQIMGEILGTFVLLLFGCAAAAQVKTSRETKGQFLSGNIAFSVGVMSAMYLCRAVSGAHLNPAVSLSFCVLGDLAWIKLLPYSLAQILGAYLASGLVYLIYHDAIMEFSGGVLTVFGPNETASIFATYPTDVVSVQTNFLDQVVGTAMLMLCILPLNDKRNAPAPEALLPPIVATVVLGISISMSANCGAAINPARDLGPRLFTFTAGWGTEVFTCYDYFFWIPLVAPMVGGVLGSIIYLVFIQWHLPELEDESESGEMNDQTKVMEHNNKKDEIYLKMSSI
Protein: GM01042p (Q95SF4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQTPNLNTCSRTASKSSSKSKSSNESTSSSPDITSRQANNNNTNSIGGHLPQNGTGGGVVAAAVSAAQNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYIDSDTGLESMSSAEATTKACSLCLDGVQSTIMGSSPSNETIVKIENLRQEVTRLKCDKLDLLRQNVTCQRDIKRLRERELSLQGDLSAAGREILRLRDLLKEYMPDTASAPLSISPI
Protein: Major facilitator superfamily (MFS) profile domain-containing protein (Q9U372)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANSSEPHHNFHGEPISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAILKRCIIDLKSLRKLRSGEESPLLNDEAGDHED
Protein: Translationally-controlled tumor protein homolog (TCTP) (p23fyp) (Q10344)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Elongation factor 1-gamma
- Elongation factor 1-beta
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein eS27
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL13
Sequence:
MLLYKDVISGDELVSDAYDLKEVDDIVYEADCQMVTVKQGGDVDIGANPSAEDAEENAEEGTETVNNLVYSFRLSPTSFDKKSYMSYIKGYMKAIKARLQESNPERVPVFEKNAIGFVKKILANFKDYDFYIGESMDPDAMVVLMNYREDGITPYMIFFKDGLVSEKF