wanglab/gogpt-training-data huggingface dataset:
Protein: Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor) (P52500)
Organism: Rattus norvegicus (Rat)
Function: Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8391296}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Gastrin-releasing peptide
- Neuromedin B
- Bombesin receptor subtype-3
- Guanine nucleotide-binding protein G
- Protein PROCA1
- Somatostatin
Sequence:
MDPNNCSHLNLEVDPFLSCNNTFNQTLNPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV
Protein: Solute carrier family 26 member 6 (A0A8I6AS58)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MELERRDYHVERPLLNQEQLEDLGHWGPVSKTHPWRTWFRCSRARAKSLLIQHVPVLGWLPRYPVREWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPMFGLYSSFYPVFVYFLFGTSRHISVGTFAVMSVMVGGVTESLTADEAFVQSLNTTVDGARVQVAYTLSFLVGLFQVGLGLVHFGFVVTYLSEPLVRSYTTAASVQVLVSQLKYVFGIKLNSHSGPLSVIYTVLEVCAQLPKTVPGTVVTAIVAGVVLVLVKLLNEKLRRRLPLPIPGELLTLIGATAISYGVKLNDRFKVDVVGNITTGLIPPVAPKTELFATLVGNAFAIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGFFQCFPVSCSMSRSLVQESTGGNTQIAGAVSSLFILLIIVKLGELFRDLPKAVLAAVIIVNLKGMMKQFSDICSLWKANRVDLLIWLVTFVATILLNLDIGLAVSIVFSLLLVVIRMQLPHYSVLGQVPDTDIYRDVAEYSGAKEVPGVKVFRSSATMYFANAELYSDSLKKKCGVDVDRLITQKKKRIKKQEMKIKRMNKAKKSQKQVHQGEELEDVVASNQEDAKPPIMTSLKALGLPQPDFHSLILDLSTVSFVDTVCIKSLKNIFRDFREIEVEVYIAACYSPVVTQLEAGHFFDESITKQHVFASVHDAVTFALHHRKSGPKSPVLATKL
Protein: Neuregulin 1 (Nrg1 protein) (Pro-neuregulin-1, membrane-bound isoform isoform 1) (B3DK99)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAEVKAGKEGKSGDKKKDKESVRSNKPDNSPQAEPKLKNLRSVTVEDGKKTVLKCEILAGNPAPNVKWYKNGKELTGKNKPKSIKIKKKKQGKISELLIRKSTEGDAGLYTCEAVNSLGKTNTTANLFIINTATSTTPSAKTSSHVTPCNESEKEYCVNHGKCFTLEVTPGNIRRLCRCPPGFTGNRCQNRDPVRVVDHKQAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRERNAAAKGPQHPHPPPENLQLVNHYMPTNPVPAHMTDKEAETSLSTNEFTSPTHPSTAITHSSSQCWSNGKAESVVSDSHAVLMKPSAENCQHGTPSHRGRLNATGGVHQLNDYLKNSREAQGSNRDSPYSERYVSAMTTPTRLSPVGLLSPVTPSSPPSEMSAPLSSLATSVPSMLTSPSGEEERPLLFRTPPILRDKSASTQGRKSGHNLRNSAHYNHGLDIPSPPPSPLHIEEEIDCLEQYKSTSVPSSAPHSPSAARTQPSGQAAPEQAVSGSNSESSSSESETEDERVGEDTPFLGLQNPLAAGSLVLDGLEGSRTNPALHLSPQHELQNRLTAVMANQDPIAV
Protein: T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1) (Q8N3R3)
Organism: Homo sapiens (Human)
Function: May regulate T-cell apoptosis.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
Sequence:
MFCHLRPMRRLCLEKIFPHWFPFSRALSGAEAVNALRPFYFAVHPDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPTQLTFYVRETDQSSSDGQEPFSTSGFRAVKFTLHTRDLLSTVLYILNSCSLSVEHIQSLNTNMHTQPLKEAKRMPDRPIKWDKSYYSFTGFKDPDEDLEQVSRVETTLTSWLDNNGKSAVKKLKNSLPLRKELDRLKDELSHQLQLSDIRWQRSWGIAHRCSQLHSLSRLAQQNLETLKKAKGCTIIFTDRSGMSAVGHVMLGTMDVHHHWTKLFERLPSYFDLQRRLMILEDQISYLLGGIQVVYIEELQPVLTLEEYYSLLDVFYNRLLKSRILFHPRSLRGLQMILNSDRYAPSLHELGHFNIPTLCDPANLQWFILTKAQQARENMKRKEELKVIENELIQASTKKFSLEKLYKEPSISSIQMVDCCKRLLEQSLPYLHGMHLCISHFYSVMQDGDLCIPWNWKNGEAIK
Protein: Peptidyl-prolyl cis-trans isomerase FKBP17-2, chloroplastic (PPIase FKBP17-2) (EC 5.2.1.8) (FK506-binding protein 17-2) (AtFKBP17-2) (Immunophilin FKBP17-2) (Rotamase) (Q9LDY5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular location: Plastid, chloroplast thylakoid lumen {ECO:0000269|PubMed:18431481}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase CYP26-2, chloroplastic
- Peptidyl-prolyl cis-trans isomerase FKBP13, chloroplastic
- Thylakoid lumenal protein TL20.3
- Peptidyl-prolyl cis-trans isomerase CYP37, chloroplastic
- Peptidyl-prolyl cis-trans isomerase CYP28, chloroplastic
- Pentatricopeptide repeat-containing protein At1g01970
- Putative chloroplast RNA binding protein family protein)
- Probable membrane metalloprotease ARASP2, chloroplastic
- Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic
- Mitochondrial transcription termination factor family protein
Sequence:
MANLFTATAPFLSLSKPFTKTASYHQCYASSSNPPEPESSSPPPPPPPPQPLASQQKRKKNVETTDWVASSLTRRFGIGAGLAWAGFLAFGVISEQIKTRIEVSQEVANTRDVEEEKEIVLPNGIRYYDQRVGGGATPRAGDLVVIDLKGQVQGTGQVFVDTFGTKDKKKMKPLALVVGSKPYSKGLCEGIDYVLRSMKAGGKRRVIVPPSLGFGVDGAELESGLQIPPNASLEYIVEIDRVSIAPA
Protein: Nucleosome assembly protein 1-like 1 (Brain protein DN38) (NAP-1-related protein) (P28656)
Organism: Mus musculus (Mouse)
Function: Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis. Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development. Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter.
Subcellular location: Nucleus {ECO:0000269|PubMed:29490266}. Cytoplasm {ECO:0000269|PubMed:29490266}. Melanosome {ECO:0000250|UniProtKB:P55209}.
Interaction partners:
- Nucleolin
- Histone H2A.Z
- Nucleophosmin
Sequence:
MADIDNKEQSELDQDLEDVEEVEEEETGEETKIKARQLTVQMMQNPQILAALQERLDGLVDTPTGYIESLPKVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKPDEEDEVSEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFVLEFHFEPNDYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPENGDLDDDAEAILAADFEIGHFLRERIIPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ
Protein: Branched-chain-amino-acid aminotransferase, cytosolic (BCAT) (EC 2.6.1.42) (Protein TWT2) (P47176)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using branched chain amino acids (leucine, isoleucine, and valine) as well as lysine and proline as the amino donors. Involved in cell cycle regulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21267457, ECO:0000269|PubMed:8798704}.
Interaction partners:
- Dihydroxy-acid dehydratase, mitochondrial
- 2-isopropylmalate synthase
- Acetolactate synthase catalytic subunit, mitochondrial
- 2-isopropylmalate synthase 2, mitochondrial
- Branched-chain-amino-acid aminotransferase, mitochondrial
- 3-methyl-2-oxobutanoate hydroxymethyltransferase
- Threonine dehydratase, mitochondrial
- Ketol-acid reductoisomerase, mitochondrial
- Acetolactate synthase small subunit, mitochondrial
- Cystathionine gamma-synthase
Sequence:
MTLAPLDASKVKITTTQHASKPKPNSELVFGKSFTDHMLTAEWTAEKGWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQDKCLVPEGKGYSLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATDYATRAWPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWLFGPNNNITEVGTMNAFFVFKDSKTGKKELVTAPLDGTILEGVTRDSILNLAKERLEPSEWTISERYFTIGEVTERSKNGELLEAFGSGTAAIVSPIKEIGWKGEQINIPLLPGEQTGPLAKEVAQWINGIQYGETEHGNWSRVVTDLN
Protein: Protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein [Includes: Probable protein phosphatase 2C 19 (AtPP2C19) (EC 3.1.3.16); Probable inactive cyclic nucleotide-dependent protein kinase At2g20050] (Q9SL76)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein kinase superfamily protein
- Autophagy-related protein 13b
- Autophagy-related protein 13a
- Ornithine aminotransferase, mitochondrial
- Protein TIME FOR COFFEE
- TIC-like protein
- Trehalase
- IQ domain-containing protein IQM1
- Cyclin-dependent kinase C-1
- Protein-tyrosine-phosphatase PTP1
Sequence:
MGCAYSKTCIGQICATKENSIRQTHQQAPSRGGTRATAAAAAVEEDNPVFNFSSDAVDDVDNDEIHQLGLSRDQEWGITRLSRVSSQFLPPDGSRVVKVPSCNYELRCSFLSQRGYYPDALDKANQDSFAIHTPFGSNSDDHFFGVFDGHGEFGAQCSQFVKRRLCENLLRHGRFRVDPAEACNSAFLTTNSQLHADLVDDSMSGTTAITVMVRGRTIYVANAGDSRAVLAEKRDGDLVAVDLSIDQTPFRPDELERVKLCGARVLTLDQIEGLKNPDVQCWGTEEDDDGDPPRLWVPNGMYPGTAFTRSIGDSIAETIGVVANPEIAVVELTPDNPFFVVASDGVFEFISSQTVVDMVAKHKDPRDACAAIVAESYRLWLQYETRTDDITIIVVHIDGLKDDAPRQLSSTGTQLQPPIPQVVELTGSESPSTFGWNSKNQRVRHDLSRARIRAIENSLENGHAWVPPSPAHRKTWEEEAHIERVLRDHFLFRKLTDSQCQVLLDCMQRLEANPGDIVVKQGGEGDCFYVVGSGEFEVLATQDGKNGEVPRILQRYTAEKQSSFGELALMHNKPLQASVRAVDHGTLWALKREDFRGILMSEFSNLASLKLLRSVDLLSRLTILQLSHVAESLSEACFSDGQTIVTKDQKLQGLYVIQKGRVKISFCTEVLESQNVSSLTTGITNEYDNLEIGTEVSIEKHEGSYFGEWALLGELKDSLSVVAVGEVVCVVLTKENFESAVGPLTNISDDGPKTRHSSFELSKESAKVTDTTALAKATLADLEWTTCLSTTDCSEIGLVHLKDKENLLSLKRFSKQKVKKLGKEAQVLKERNLMKNVIKPSAIVPEILCTCVDQTFAAILLNTTLACPISSLLHSPLDESSVRFITGSLVSAIEDIHKNEILFRGSSPELLMLDQSGYLQIVDFRFAKKLSGERTFTICGNADYLAPEIVQGKGHGYAADWWALGVLIYYMLEGEMPFGSWRESELDTFQKIAKGQLTFPRVLSSEAEDLITKLLEVDENLRFGSQGGPESIKKHPWFNGLKWEAISNREFQVPQEIISRIHHHLENDNVLPLETSKSLDTTEDQDAQNWLEEW
Protein: Alcohol dehydrogenase (EC 1.1.1.1) (P00334)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- aldehyde dehydrogenase
- Alcohol dehydrogenase class-3
- Aldehyde dehydrogenase type III, isoform Q
- LD24679p
- Uncharacterized protein, isoform B
- Glycerol-3-phosphate dehydrogenase [NAD
- monoamine oxidase
- aldehyde dehydrogenase
- Dehydrogenase/reductase 4
- O-acyltransferase
Sequence:
MSFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKLLKTIFAQLKTVDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKAIELNQNGAIWKLDLGTLEAIQWTKHWDSGI
Protein: Bcl-2 Bcl-2 homology region 1-3 domain-containing protein (Q3TN22)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
FSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVGAYKQVSSFVAEFIMNNTGEWIRRNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
Protein: CipC-like antibiotic response protein, putative (Q4WUQ8)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
Sequence:
MAWGWEQSDEAHREVYGERRHESSLSHELIAGAASFAGMKAWEDHQRKEGKPVSHAFAKEALAGFVGAEVDKLIETKGLDEADKIRARRHAKENAERMYDEHYVDRHGAPEYDPGRYPPHERFDRPVDRW
Protein: Acireductone dioxygenase (Fe(2+)-requiring) (Q57UT9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEPDTDAAQRLKEEQEIRERDLKRQKEKEERERRAAAEREAEENRRREAEERRIEEEKRRKRQEEEWRRLGSDIIQDLPPIPPSVVNDGLVDMWYLDDVTSKPQLCLASLKKGRKRDAPVPTLQQLKELGIIYFNVSLNDFSVVRQIVKERNYKHTDEVKLSQTCKDEQFLERWYQEHYNEDEQIRIVVDGSCFIDVRSKQDKWIRIHAKTGDLFVFPPGLYQRGTLDEDDFVALYRIFRDSTRFAPIFRSNPRAESQKVRLNYLMLLKKGNVGKELGFR
Protein: Tubby-related protein 3 (Tubby-like protein 3) (O88413)
Organism: Mus musculus (Mouse)
Function: Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes.
Subcellular location: Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm. Secreted. Note=Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha (By similarity). Does not have a cleavable signal peptide and is secreted by a non-conventional pathway. {ECO:0000250}.
Interaction partners:
- Tetratricopeptide repeat protein 21B
- Intraflagellar transport protein 122 homolog
- Intraflagellar transport protein 140 homolog
- G-protein coupled receptor 161
- WD repeat-containing protein 19
- Intraflagellar transport protein 43 homolog
- WD repeat-containing protein 35
- Intraflagellar transport protein 88 homolog
- ADP-ribosylation factor-like protein 13B
- Melanin-concentrating hormone receptor 1
Sequence:
MEAARCAPGPRGDSAFDDETLRLRQLKLDNQRALLEKKQRKKRLEPLMVQPNPEARLRRLKPRGSEEHTPLVDPQMPRSDVILHGIDGPAAFLKPEAQDLESKPQVLSVGSPAPEEGTEGSADGESPEETAPKPDLQEILQKHGILSSVNYDEEPDKEEDEGGNLSSPSARSEESAAASQKAASETGASGVTAQQGDAQLGEVENLEDFAYSPAPRGVTVKCKVTRDKKGMDRGLFPTYYMHLEREENRKIFLLAGRKRKKSKTSNYLVSTDPTDLSREGESYIGKLRSNLMGTKFTVYDHGVNPVKAQGLVEKAHTRQELAAICYETNVLGFKGPRKMSVIIPGMNMNHERIPFRPRNEHESLLSKWQNKSMENLIELHNKAPVWNDDTQSYVLNFHGRVTQASVKNFQIVHGNDPDYIVMQFGRVADDVFTLDYNYPLCALQAFAIGLSSFDSKLACE
Protein: Ferritin-4, chloroplastic (EC 1.16.3.1) (Q9S756)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).
Subcellular location: Plastid, chloroplast {ECO:0000250}.
Interaction partners:
- Protein RALF-like 1
- GPI-anchored protein LLG1
- Rapid alkalinization factor 23
- Receptor-like protein kinase THESEUS 1
- Probable receptor-like protein kinase At1g30570
- GPI-anchored protein LORELEI
- Receptor-like protein kinase HERK 1
- Leucine-rich repeat extensin-like protein 3
- ATPase 2, plasma membrane-type
- Leucine-rich repeat extensin-like protein 4
Sequence:
MLLKTVSSSSSSALSLVNFHGVKKDVSPLLPSISSNLRVSSGKSGNLTFSFRASKSSTTDALSGVVFEPFKEVKKELDLVPTSSHLSLARQKYSDECEAAINEQINVEYNVSYVYHAMYAYFDRDNIALKGLAKFFKESSLEEREHAEKLMEYQNKRGGRVKLQSIVMPLSEFEHVDKGDALYGMELALSLEKLVNEKLLNLHSVASKNNDVHLADFIESEFLTEQVEAIKLISEYVAQLRRVGKGHGTWHFNQMLLEG
Protein: AT3g24190/MUJ8_17 (Protein kinase superfamily protein) (Q9LRN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein kinase superfamily protein
- Probable disease resistance protein At1g62630
- Disease resistance RPP8-like protein 3
- Probable disease resistance protein At1g12290
- Probable disease resistance protein At1g59620
- non-specific serine/threonine protein kinase
- Probable serine/threonine-protein kinase At1g01540
- Outer envelope pore protein 16-1, chloroplastic
- non-specific serine/threonine protein kinase
- Putative disease resistance protein At3g14460
Sequence:
MEAAVPRLVNCGPEPIRFSVSSRRSFVSGIPHRNKRSRQILAVATDPKPTQTSPPKSTTVNGSSSPSSASKVVNNNVSTRINDVSKEIKRVRAQMEEDEQLSVLMRGLRGQNLKDSVFADDNIQLRLVETGESSEFLPLVYDPETISAYWGKRPRAVASRVIQLLSVAGGFLSRIAGDVINKKVKENEVARAIELREIVTSLGPAYIKLGQALSIRPDILSPAAMTELQKLCDKVPSYPDDVAMALIEEELGKPWYDVYSELSPSPIAAASLGQVYKGRLKENGDLVAVKVQRPFVLETVTVDLFVIRNLGLFLRKFPQVSVDVVGLVDEWAARFFEELDYVNEGENGTYFAEMMKKDLPQVVVPKTYQKYTSRKVLTTSWIDGEKLSQSIESDVGELVNVGVICYLKQLLDTGFFHADPHPGNMIRTPDGKLAILDFGLVTKLTDDQKYGMIEAIAHLIHRDYDAIVKDFVKLGFIPDGVNLAPILPVLAKVFDQALEGGGAKNINFQELAADLAQITFDYPFRIPPYFALIIRAIGVLEGIALVGNPEFAIVDEAYPYIAQRLLTDESPRLREALRYTIYGKTGVFDAERFIDVMQAFETFITAAKSGGGEDMNGGMAEMALMQSKTSSLVPMFPASASQPDQPVQTRVALSFLLSEKGNFFREFLLDEIVKGIDAITREQLVQAMAVFGFRNATPIFGMLPPTLGPFKPAALLPSVTEEDKVILNNVQKVIEFLTARSSMSNNPDQVVDVSQVVRELLPVLPGISATVLPEILSRLGSRVMARIVRDAFL
Protein: AT-rich interaction domain 1A (A0A1B0GTU5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
SPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPYGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQPQSQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQPSGGQIHTGMGSYQQNSMGSYGPQGGQYGPQGGYPRQPNYNALPNANYPSAGMAGGINPMGAGGQMHGQPGIPPYGTLPPGRMSHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQETAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYSMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMRSNSVGIQDAFNDGSDSTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGNVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMSTGAPQPNLMPSNPDSGMYSPSRYPPQQQQQQQQRHDSYGNQFSTQGTPSGSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSTGQGQPQQQQLPPAQPQPASQQQAAQPSPQQDVYNQYGNAYPATATAATERRPAGGPQNQFPFQFGRDRVSAPPGTNAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQSTGSAPQGPAYHGVNRTDEMLHTDQRANHEGSWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPAPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFSKVSSPAPMEGGEEEEELLGPKLEEEEEEEVVENDEEIAFSGKDKPASENSEEKLISKFDKLPVKIVQKNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKTELLPSRPHAPCPPAPRKHVTTAEGTPGTTDQEGPPPDGPPEKRITATMDDMLSTRSSTLTEDGAKSSEAIKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCNKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS
Protein: Switching B cell complex subunit SWAP70 (E7EMB1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILEKIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE
Protein: Transmembrane protein 208 (Q9BTX3)
Organism: Homo sapiens (Human)
Function: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23691174, ECO:0000269|PubMed:38381787}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- DNA repair protein SWI5 homolog
- Autophagy-related protein 9A
- Autophagy-related protein 9B
- PAT complex subunit Asterix
- Reticulon-4
Sequence:
MAPKGKVGTRGKKQIFEENRETLKFYLRIILGANAIYCLVTLVFFYSSASFWAWLALGFSLAVYGASYHSMSSMARAAFSEDGALMDGGMDLNMEQGMAEHLKDVILLTAIVQVLSCFSLYVWSFWLLAPGRALYLLWVNVLGPWFTADSGTPAPEHNEKRQRRQERRQMKRL
Protein: Fructose-1,6-bisphosphatase 1 (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) (Q7T337)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Transaldolase
- Transketolase
- transketolase
- Glucose-6-phosphate isomerase
- Glucose-6-phosphate isomerase
- ATP-dependent 6-phosphofructokinase
- ATP-dependent 6-phosphofructokinase
- Fructose-bisphosphate aldolase B
- ATP-dependent 6-phosphofructokinase
- ATP-dependent 6-phosphofructokinase
Sequence:
MSDRGAFDTNVVTLTRFVLEEGRKAKGTGELTTLLNSMCTAIKAISTAVRKAGIANLYGIAGSTNVTGDQVKKLDVLSNDLVINMIKSSFTSCVLVSEEDEKAVIIEPEKRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKETDDEPSEKDALRSGRHIVAAGYALYGSATMLVLSTGQGVNCFMLDPAIGEFILVDRDVRIKKKGKIYSLNEGYAQQFYPDVTEYLQKKKFPEDGSSPYGGRYVGSMVADVHRTLVYGGIFLYPANVKSPKGKLRLLYECNPMAFIMEQAGGMATTGAMNVLDIQPESIHQRVPVVLGSPDDVKEYISIYKKHAK
Protein: Ubiquitin-conjugating enzyme 14 (F4IWU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MANNQASLLLQKQLKDLCKKPVDGFSAGLVDEKNVFQWSVSIMGPPDTLYEGGFFNAIMSFPENYPVSPPTVTFTSEMWHPNVYSDGKVCISILHPPGDDPHGYELASERWTPVHTLVETDMFCSILSLYSDCFSNVRGIYKSGLRNTLEDKSIVLSIISMLSGPNDESPANVEAAKEWRDNRAEFRKKVSRCVRRSQEML
Protein: Proteasome subunit alpha type (B5X8S5)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Interaction partners:
Sequence:
MKLISAIWSVQQSFPQDRSTMAERGYSFSLTTFSPSGKLVQIEYALAAVATGAPAVGIKASNGVVLATEKKQKSILYDETSVHKVEPITKHIGMVYSGMGPDYRVLLRRARKLAQQYFLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVPLLIAGWDEDRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLSPAEVKDYLAAIA
Protein: Elongation factor 1-alpha (Q0PY11)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
Protein: Microtubule-associated protein 1 light chain 3 gamma (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (Microtubule-associated proteins 1A/1B light chain 3C) (MAP1A/MAP1B LC3 C) (MAP1A/MAP1B light chain 3 C) (Q9BXW4)
Organism: Homo sapiens (Human)
Function: Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.
Subcellular location: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:12740394, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:31709703}; Lipid-anchor {ECO:0000269|PubMed:12740394}. Endomembrane system {ECO:0000269|PubMed:12740394}; Lipid-anchor {ECO:0000269|PubMed:12740394}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12740394}. Note=LC3-II binds to the autophagic membranes. {ECO:0000269|PubMed:12740394}.
Interaction partners:
- Calcium-binding and coiled-coil domain-containing protein 2
- Cysteine protease ATG4B
- Ubiquitin-like modifier-activating enzyme ATG7
- Ubiquitin-like-conjugating enzyme ATG3
- Sequestosome-1
- Next to BRCA1 gene 1 protein
- Pleckstrin homology domain-containing family M member 1
- WD repeat and FYVE domain-containing protein 3
- Serine/threonine-protein kinase ULK1
- Autophagy-related protein 13
Sequence:
MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFGCLESAAPRDGSSLEDRPCNPL