wanglab/gogpt-training-data huggingface dataset:
Protein: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) (P51639)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04035}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}. Peroxisome membrane {ECO:0000250|UniProtKB:P04035}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}.
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- Insulin-induced gene 1 protein
- Squalene monooxygenase
- Mevalonate kinase
- Lanosterol 14-alpha demethylase
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- Sterol regulatory element-binding protein 2
- Protein kinase AMP-activated non-catalytic subunit gamma 2
- Protein kinase AMP-activated non-catalytic subunit gamma 3
Sequence:
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQSKVSLGLAEDVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVTPKKAQDNCCRREPLLVRRNQKLSSVEEDPGVNQDRKVEVIKPLVAEAETSGRATFVLGASAASPPLALGAQEPGIELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSAKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMSRGPVVRLPRACDSAEVKSWLETPEGFAVVKEAFDSTSRFARLQKLHVTLAGRNLYIRLQSKTGDAMGMNMISKGTEKALLKLQEFFPELQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKAA
Protein: T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1) (Q3MHL7)
Organism: Bos taurus (Bovine)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P40227}.
Interaction partners:
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit gamma
- Chaperonin containing TCP1 subunit 8 like 2
- Uncharacterized protein
- T-complex protein 1 subunit theta
Sequence:
MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG
Protein: Phosphorylase b kinase regulatory subunit (A0A8I5ZWF0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}.
Interaction partners:
Sequence:
MRSRSNSGVRLDGYARLVQQTILCYQNPVTGLLSASHDQKDAWVRDNIYSILAVWGLGMAYRKNADRDEDKAKAYELEQNVVKLMRGLLQCMMRQVDKVEKFKHTQSTKDSLHAKYNTATCSTVVGDDQWGHLQVDATSLFLLFLAQMTASGLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMWERGDKTNQGIPELNASSVGMAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQSILFSMLPRASTSKEIDAGLLSIISFPAFAVEDVHLVNVTKNEIISKLQGRYGCCRFLRDGYKTPREDPHRLHYDPAELKLFENIECEWPVFWTYLIIDGVFNGDAVQVQEYREALEGILIRGKDGIHLVPELYAIPPDKVDEEYKNPHTVDRIPLGKLPHLWGQSLYILSSLLAEGFLATGEIDPLNRRFSTSVKPDVVVQVAVLAENSHIKGLLKQHGINVQSIADVHPIRVQPGRILSHIYAKLGQNKNMKLSGRPYRHIGVLGTSKLYVIRNHIFTFTPQFTDQHHFYLALDNEMIVEMLRIELAYLCTCWRMTGRPTLTFPVTHTMLTNDGSDIHPAVLSTIRKLEDGYFGGARVKLGILAEFLTTSFYTYLTFLDPDCDEKLFGDISDRSFSPDSESDLGGYLEDSSHQESQDELDQYISHLLQSTSLKCYLPPLCKKSEDSHVFSAVHSTRDILSVMAKAKGLETPFFPMILPTRVLSGHRKSLNLVDSPQPFLKKTPEYDYQWPRDDQDEVDCEKLVGQLKDCSNLQDQADILYILYVIKGPRWDTNLFGQHGVTVHSLLGELYGKAGLNQEWSLIRYISGLLRKKVEVLAEACADLLSHQKQLTVGLPPEPREKTISTPLPPEELTELIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLFAEMLRLRIGLIIQVMATELARSLNCSGEEASESLMNLSPFDMKSLLHHILSGKEFGVERSVRPIHSSMSSPAISIHEVGHTGVTKTERSGISRLRSEMKQMNRRASADEQRSSTPSSPTGTSSTDSGGHHLGWGEQQGQWLRRRRLDGAINRVPVGFYQRVWKILQKCHGLSIDGYVLPSSTTQEMTPCEIKFAVHVESVLNRVSQPEYRQLLVEAIMVLTLLSDTEMDSIGGIIHVDQIVQLANQLFLQDQVSFGTTDILEKDQATGICHLFYDSAPSGAYGTMTYLTKAVASHLQDLLPSSGCQMQ
Protein: LD25641p (Q95TS6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSGAASAKGRDYDLSEIRSELKGFQPKLLTNAASNEERKDLAKKEPSDEPALQDIKKEPKLESSAKSSSTELSSETESYADEDSQSSDYRKQLKGSGAGKKEPTASPSKLHHEPVTKRELAVKEEPLKIEPKTEPKEEETKSKPFLSGADIKPTALIAPARFGNTSAAQAASSSGSSSTTAKYTSVIVEKPLTIGGKKSVEQHVPKKAELLKKQSGGAGGTAASSSAASQESKKFAEPVASLKVEMPAACSPSSSSSSSSSFCSTGSAVSSSSATRSLPDMSKLEISSGTVPGATPGAAALQPSNVAQVSSSGAAKESKYSSSGGAAAGSGISMRKLLSSDVYEFKDTEPFEFEKRISPMASVGGTVAAAATAAGAMAAAGAASVITTMVPTPGASGSGVAASASTSAPVVVGSAARKQALKASAIQHILEHQSPAAGRERGGYGGMTSSISLLTAPKLKKRGSPLKEAALCMEKAKTYKLDKDQVQQPVEQKTQQLIQPTLGPVESYGAGSPEAMSNLSTPTTSSGHAQLSASSTYSQLTPHHATPFDALRKSPSFNLNITALNEELAQTVQETTRALTDALQPPSTPVPPTVSASGSTPTAVTPVITAMPTAGTAGLSCPSTPPTGANPVLASPKLSTPPQAINASKQPPASHIVGSPFIETRNVFELSTSNEGSGYSSGESKDNKFEKLENVKILLAGAVGPFDLDAGSYEQKTSSIADKVLKAISQKKEEVENNKGKPPVEPAAAAKTPGREDVVPSPTAKLDLCSSAIKLDTLKLLSEPLKIQTGPLLGELYRPGPATSSPETKSILESSLPAKNSELSETIQKLECAIQQRKTPVGGALSLASSTVGTPPTAHTPNSTATAGAGFSDESMDSTDSEQRLVIEDVIAEEHTTTTTTGEQKSPGSQQEEGQTNTATMATAVTAETEGTSSSTPTPPVPAPVKLELGAKAMPGIQAPIPLKPAEGSSFAGKLTGVVQPPPLAKLQQQEELGQAQGQSKSISSFGIPIVLPEIPASVVVATPALMVASAATVMRHSPGSTPNSQAPVLISPKTFLTAPKVGEVGGLLLKAYTGVSGAVGAAPAGSVIASAGGGGTPTVISNFPQQQQQASVLQASSEMPANYVLDAEMAEPSNSSAPVVARPFVMHAVGKELFNVVAPAASSPLISDPHNESINLLCEETIPGSPAPNYGGTDQLPTAVNSALAIVGITPLPPDTPPPVPVAAIQQQQQHQLQSGQQQQAAKTGEVNPSGPNSSPDSASQDESGEEAKKNAGLEHEDSTGLGALNKRKRNRKPLPMSAQTAAAVAAQLQSLGKRRRQVSGMRNQKTTTTAAGSDTDDNSDNIAPNAGQQQQQPRQSARQHMMPQSNAQQQQQQQLLQQQQTQLPQGIQSTNSSGVRPCPYNFLVELDPALSSDECITILRKQIQDLRKAYNTIKGELAVIDRRRKKLRRREREKKQQQLQSQQQGKICA
Protein: Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP (EC 7.4.2.1) (P07109)
Organism: Escherichia coli (strain K12)
Function: Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system (By similarity).
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:P02915}; Peripheral membrane protein {ECO:0000250|UniProtKB:P02915}.
Interaction partners:
- Histidine/lysine/arginine/ornithine transport system permease protein HisM
- Histidine/lysine/arginine/ornithine transport system permease protein HisQ
- Histidine-binding periplasmic protein
- Lysine/arginine/ornithine-binding periplasmic protein
- L-cystine transport system permease protein TcyL
- Glutamine transport system permease protein GlnP
- Glutamate/aspartate import permease protein GltK
- Putrescine export system ATP-binding protein SapD
- Nickel import ATP-binding protein NikD
- Arginine ABC transporter permease protein ArtM
Sequence:
MSENKLNVIDLHKRYGEHEVLKGVSLQANAGDVISIIGSSGSGKSTFLRCINFLEKPSEGSIVVNGQTINLVRDKDGQLKVADKNQLRLLRTRLTMVFQHFNLWSHMTVLENVMEAPIQVLGLSKQEARERAVKYLAKVGIDERAQGKYPVHLSGGQQQRVSIARALAMEPEVLLFDEPTSALDPELVGEVLRIMQQLAEEGKTMVVVTHEMGFARHVSTHVIFLHQGKIEEEGAPEQLFGNPQSPRLQRFLKGSLK
Protein: Tubulin beta 8B (A6NNZ2)
Organism: Homo sapiens (Human)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Tubulin-like protein alpha-4B
- Tubulin alpha chain-like 3
- Tubulin alpha-3E chain
- Tubulin alpha-8 chain
- Tubulin alpha-3C chain
- Tubulin alpha-1C chain
- Tubulin alpha-1B chain
- Tubulin alpha-4A chain
- Tubulin alpha-1A chain
Sequence:
MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYVPRAVLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMMAACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAVCDIPPRGLKMSATFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDEEYAEEEVA
Protein: Wolframin ER transmembrane glycoprotein (E9PT53)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Cyclic AMP-dependent transcription factor ATF-6 alpha
- Atf6b protein
- CDGSH iron-sulfur domain-containing protein 2
Sequence:
MSSGTPPPSPSGPPPPPAPQPQARARLNATTSLEQDKIEPPRAPRPQPDSSAGRSAGEATTPEPWAPHASSREGTDKAGPMKADVEIPFEEILEKAKAGDPKAQTEVGKHYLRLANDADEELNSCSAVAWLILAAKQGRREAVKLLRRCLADRKGITSENEAEVKQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVSELLENVGQVNEQDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGIIPNNLFLQDEDEDEDELSGKSPEDLPLRQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTIVPTHHINALIFFFIISNLTIDFFAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVVSAFFTVTSYMSLSSSAEPYTRRALVTEVAAGLLSLLPTMPVDWPFLKALGQTFFTVPIGHFIILNVSLPCLLYVYLFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIGYFLFLFALPILVAGLALMGTVQFARWFLSLDLTKIMVTTVICSVPLLFRWWTKANFSVVGMVKSLTRSSIVKLILVWLTAILLFCWFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTEIDNSAESAINMLPFFLGDWMRCLYGEAYPSCSSGNTSTAEEELCRLKQLAKHPCHIKKFDRYKFEITVGMPFGTNGNRGHEEDDITKDIVLRASSEFKDVLLNLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMTQLSPARRHVKIEQDWRSTVHGALKFAFDFFFFPFLSAA
Protein: Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) (P67811)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:3511473, ECO:0000269|PubMed:8444896}; Single-pass type II membrane protein {ECO:0000269|PubMed:8444896}.
Interaction partners:
- Signal peptidase complex subunit 2
- Signal peptidase complex subunit 3
- Signal peptidase complex subunit 1.
- Signal peptidase complex catalytic subunit SEC11C
- Succinate-semialdehyde dehydrogenase
- Uncharacterized protein.
Sequence:
MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVITGSESPIVVVLSGSMEPAFHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIHEKQNGHIKFLTKGDNNAVDDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYPKFKYAVLFLLGLFVLVHRE
Protein: Thymus-specific serine protease (EC 3.4.-.-) (Serine protease 16) (Q9QXE5)
Organism: Mus musculus (Mouse)
Function: Protease that may play a role in T-cell development.
Subcellular location: Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal.
Interaction partners:
- Proteasome subunit beta type-11
Sequence:
MAVKAPWLGFLLLVSLWGLSTPALLLRRLREHIQKFQESSSLHPGFGLGHGPGAVPKQGWLEQPLDPFNASDRRTFLQRYWVNDQHRTGQDVPVFLHIGGEGSLGPGSVMAGHPAALAPAWGALVISLEHRFYGLSMPAGGLDLALLRYLSSRHALADVASARQALSGLLNVSSSSPWICFGGSYAGSLATWARLKFPHLVFAAVASSAPLSAVVDFSAYNQVVARSLTQVAIGGSLECLAAASTAFTEVERLLRAGPAAQAVLREELGACGSLDLTEDQAELLGALQALVGGTVQYDGQAGAPLSVRQLCGLLLGKWGNRSRSTPYLGLRRAVQIVLRSMGQKCLSFSRAETVAQLSNTEPQVSGVGDRQWLYQTCTEFGFYVTCEGLQCPFSQLPALPFQLELCEQVFGLSPASVAQAVAQTNSYYGGQSPGATQVLFVNGDTDPWHVLSVTQDLGLSEPALLIPSASHCFDMAPMRPSDSPSLRLGRQKISQQLQDWLKDIKKSQS
Protein: T. brucei spp.-specific protein (Q57TV0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNPCEDVSNSRHNCAHDISSSGSGPATATATAKGAANASRNSSTSHRQPFYVLSSSDGTWFAHLPGATGPSCSGITRNPQHLPCGASWSSSSPQFMTPKGVSQSIFRENWGFMQDGTPADVPRTTEIPTATTTGKLPLPNFYVGEPARRGSCSTSQEFHQHVMEEQRRQMGQLIHQHTPGKHLS
Protein: UPF0073 inner membrane protein YqfA (P67153)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein.
Interaction partners:
Sequence:
MVQKPLIKQGYSLAEEIANSVSHGIGLVFGIVGLVLLLVQAVDLNASATAITSYSLYGGSMILLFLASTLYHAIPHQRAKMWLKKFDHCAIYLLIAGTYTPFLLVGLDSPLARGLMIVIWSLALLGILFKLTIAHRFKILSLVTYLAMGWLSLVVIYEMAVKLAAGSVTLLAVGGVVYSLGVIFYVCKRIPYNHAIWHGFVLGGSVCHFLAIYLYIGQA
Protein: Apoptotic chromatin condensation inducer 1 (S4R3H4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPAVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVALPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR
Protein: 1-aminocyclopropane-1-carboxylate synthase 4 (ACC synthase 4) (EC 4.4.1.14) (S-adenosyl-L-methionine methylthioadenosine-lyase 4) (Q43309)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene.
Interaction partners:
- 1-aminocyclopropane-1-carboxylate oxidase 4
- 1-aminocyclopropane-1-carboxylate oxidase 1
- 5'-methylthioadenosine nucleosidase
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- Aconitate hydratase 1
- S-adenosylmethionine synthase 2
- S-adenosylmethionine synthase 1
- 1-aminocyclopropane-1-carboxylate oxidase
- 1-aminocyclopropane-1-carboxylate oxidase 2
- 1-aminocyclopropane-1-carboxylate oxidase 5
Sequence:
MVQLSRKATCNSHGQVSSYFLGWEEYEKNPYDVTKNPQGIIQMGLAENQLCFDLLESWLAQNTDAACFKRDGQSVFRELALFQDYHGLSSFKNAFADFMSENRGNRVSFDSNNLVLTAGATSANETLMFCLADPGDAFLLPTPYYPGFDRDLKWRTGVEIVPIQSSSTNGFRITKLALEEAYEQAKKLDLNVKGILITNPSNPLGTTTTQTELNILFDFITKNKNIHLVSDEIYSGTVFNSSEFISVMEILKNNQLENTDVLNRVHIVCSLSKDLGLPGFRVGAIYSNDKDVISAATKMSSFGLVSSQTQYLLSSLLSDKKFTKNYLRENQKRLKNRQRKLVLGLEAIGIKCLKSNAGLFCWVDMRPLLRSKTFEAEMDLWKKIVYEVKLNISPGSSCHCEEPGWFRVCFANMIDETLKLALKRLKMLVDDENSSRRCQKSKSERLNGSRKKTMSNVSNWVFRLSFHDREAEER
Protein: Angiotensin-converting enzyme (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (Q10714)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.
Subcellular location: Secreted, extracellular space.
Interaction partners:
- ADAM 17-like protease
- Neprilysin-2
- GH24474p
- GH26575p
- Neprilysin-like 20
- Neprilysin-1
- Neprilysin-3
- Neprilysin-4
- FI12805p
Sequence:
MRLFLLALLATLAVTQALVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVSS
Protein: Paired amphipathic helix protein pst2 (SIN3 homolog 2) (O13919)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810, ECO:0000269|PubMed:12773392}.
Interaction partners:
- Histone deacetylase clr6
- Chromatin modification-related protein eaf3
- RbAp48-related WD40 repeat-containing protein prw1
- Uncharacterized protein C16C9.05
- Uncharacterized protein C2F7.07c
- Transcriptional regulatory protein sds3
- Chromatin modification-related protein png2
- Transcriptional regulatory protein rxt3
- Putative histone deacetylase complex subunit cti6
- Transcriptional regulatory protein rxt2
Sequence:
MEQTLAILKNDNSTLVAEMQNQLVHDFSPNGTALPELDIKAFVQKLGQRLCHRPYVYSAFMDVVKALHNEIVDFPGFIERISVILRDYPDLLEYLNIFLPSSYKYLLSNSGANFTLQFTTPSGPVSTPSTYVATYNDLPCTYHRAIGFVSRVRRALLSNPEQFFKLQDSLRKFKNSECSLSELQTIVTSLLAEHPSLAHEFHNFLPSSIFFGSKPPLGSFPLRGIQSSQFTLSNISDLLSQSRPDNLSPFSHLSNESSDFFKNVKNVLTDVETYHEFLKLLNLYVQGIIDRNILVSRGFGFLKSNSGLWRSFLSLTSLSPEEFLSVYNSACSDFPECGPSYRLLPVEERNISCSGRDDFAWGILNDDWVSHPTWASEESGFIVQRKTPYEEAMTKLEEERYEFDRHIEATSWTIKSLKKIQNRINELPEEERETYTLEEGLGLPSKSIYKKTIKLVYTSEHAEEMFKALERMPCLTLPLVISRLEEKNEEWKSVKRSLQPGWRSIEFKNYDKSLDSQCVYFKARDKKNVSSKFLLAEADILRSQAKLHFPLRSRSAFEFSFVYDNEIVLFDTCYMVCTYIVCNSPSGLKKVEHFFKNILPLHFGLEKDKFSIFLDQVFRGPDYDVNAPNIVGNKPVRRKRSNSITQLTEFVKQPKINGQRESRSAAAARKKEESGNKSQSNSQNSLSDESGNVTPVSKKQLSQPAAAIKASLKYPSHPDSLLEHQDHAGDTENEMHDDVDKEQFGYSSMYVFFRLFNLLYERLYELQRLEDQVSIIQQRIIPNPVSQKQKIWRDRWNDLSDVPDEKTHYENTYVMILRLIYGIVDQSAFEDYLRFYYGNKAYKIYTIDKLVWSAAKQVHHIVSDGKYKFVTSLVEQNSSASPKKNYDDFLYRLEIEKLLNPDEILFRFCWINKFKSFGIKIMKRANLIVDQSLDTQRRVWKKYVQNYRIQKLTEEISYKNYRCPFLCRNIEKERTVEQLVSRLQTKLLRSAELVSGLQAKLCLDSFKLLYLPRTEDSYIDASYLRLRDTDFLDCQNKRKQRWRNRWESLLKSVRGTSDNTAEVNFDADINALFIP
Protein: Growth hormone (Q0QBF7)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MMAAGPRTSLLLAFTLLCLLWTQVVGAFPAMSLSRLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTSKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDVTPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
Protein: Integrin beta-like protein C (Q54JA5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Implicated in cellular adhesion.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Latrophilin receptor-like protein A
- Putative phagocytic receptor 1a
- Protein psiH
Sequence:
MNKLFYLFILIASLFILTDASHFRFGTISWQPTTDYRTIKFTSNFAYRTTFFYSSTSSIKVGNLVNVGTLNFGSGVGSVTVSVTVTDFDVKNNWFTGTFTTTKAYPAQNSGTIREYTAIFTSCCRISSLLNNKDASWNITTSVQIDNKNELSMVNWSPVSGMIPIVQVVANKNNNFRVIASDQNVQNADSSALTFSFSKVYTMTQPSGMTIDSKGNCYFLPTQIGLYSTQIYILDSRGAYIVVDFILQSVAEPGTCDPTCSNAGTACNQNSQCKGCTNSGSTTIDTCTTSNYPPDFVSPPTPDDGDTKLFPIGASTSLTFSCKTIMSGRSTTIQTANLPVGVTTKTPVTGATSNTTITWTPTTANTGSYVVSLVCSDSTGLTSSVRSFTILVAKPDCGNGGYTESGVCKCVDNWDPASKCFECKDGYYGENCVAVPPCVNGVPNSGINGDGKCLCSNGWTGADCSISSSQSCKDLSNSNTSISYSNPSFVNPTKVQVYLTSTPNYEVPTIVSIPNPINNLDVYVLVDANLASTTAFGYIKSGMSTFVSNIENICETAQFGIGYFSDYTPSPISFSPSQVMGSPIAAAIGLYKPATYSTTSNGNSLLAATDAASASVGWNSGSFKVIVIITDSDHSSSSAQITAFTNKFIGKSIVPVVVSFGASSMTNWNSALTSAGFGSVVTASGTSASDWSAKANTGVKNVLSKIVYKSDPTATGSSFVSSVPSTVTVSSSSSTQQTVNGLKLSLPSGTTIVSPVATISAMGYGQTDISINYNRPPVATSGSFSVNQNSLATFKLTGTDPDANILQFKFTTFLTANAGVITDSNGKDVSKQQSNYYAASEIFTYTPFENYLASNTIRFVAFDGCVESNTYATISITINKVNQLPECSSISSTITTTLNTQSTFSMTATDFEDASPFLQFTKPTDLTAYGTFTYKGASITSSTKITTGDSVIFTQTVNPKNDATVTLEFRAIDTSNAFSQASCSVSFKIQHANVAPVSSSTSPISVIPRGSVSLTLVSTDSDSTKALFTITAIKNGNNGNFYTCSTNDCSCTSGSSDSTIISLKDQFSGISYSSTKANKLICFTNGEPSAISNYASISFTSTDDEGLESNTVSVVVNIVGDRANVAPVVTKIQDYSVYQDYLDSDAHVVTGTDADIDDYNPPNVNNLIAIITTPPSNGILVTVQNGNNVATQGNAPFTHYYRPNPGFKGTDSYSYQVMDTFKETSSVESTTVTVNPINHKPTLTVNSYSFTSQSGAGETQTLVTYDFDGDNVLCSVQAAPKQISMYDSENELITTLPKSLSSNSYSFKLLDASKISPTPFSSFSDSFIISCKDDSKLTTPYGVLSTGNVTGFVQFTYINTPPTTKGIQVELDQDTTEPFTFNGTDIESPSDLKAKIYALPANGQLLNGNVVLTSKLIGEETYELDALSYKPNAGLSNWNTIDNIGPLDSIPYSVVDQQGLVSDSDVVTFSVRPRNPPVYTGADVIDVLQNTRYPLNVQGKVGNGGSEVNIQVLKFSGRGTLSIAHSMGSEGTMDTEITSYPNSQTGSTSYNFAYMPPHNEYGNDFDFIEFKLFDGDLYSELYTITVNVIHVNQPPTIQLISYKVLDDTSKDNGEVLFDSTYIVNMNINTSVLIKYTGSDVDVDQVTPLLSTVTTALRGTLYTKDETVPDLKGSIIDRNHTTVEQSSDGYYYVVYSPVPDSSGNSYVRIPFFMTDNGGLDSPTLTAVINVNRYNIPPFVLAGNKTYSTTTKLALSVENVQFDDPDSGKSNNVSIVVSIVGENDENVASLEDIKISLKRMQNCELHTSLASISCLDTKSALNESIQTITVNAVTAGNYRLKLFVDDLGYNAPSAIRAQSHMNATGYVDVTFEEAETTTQTNDNKTVLTGAIAGAAAGTALIAAAAWRLLRKAAPPTDTFFSEAAFLGDGVSSNPLYEQSASAAENPLYQSASDTTD
Protein: CG17304 (Q2XYH6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
RLPATPTQTANNKHRAAAAAAAVAAAAAVAAGEPNSNSMLQYGGSNTSATVPTTVSTASAASALGMGVTGGGMGGGRNMAMGMGMVGGMGGMGMGGGMAPYNLHGSTMGSSCESTSVERIPVDTIDALGPELAVATSQVLENLSENERKMIIEVLNRDESVRQR
Protein: Ornithine decarboxylase (ODC) (EC 4.1.1.17) (P08432)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Spermidine synthase SPE3
- Arginase
- S-adenosylmethionine decarboxylase proenzyme
- Spermine synthase SPE4
- Polyamine oxidase FMS1
- Ornithine aminotransferase
- Ornithine decarboxylase antizyme
- Deoxyhypusine synthase
- Aspartate-semialdehyde dehydrogenase
- Protein ARG5,6
Sequence:
MSSTQVGNALSSSTTTLVDLSNSTVTQKKQYYKDGETLHNLLLELKNNQDLELLPHEQAHPKIFQALKARIGRINNETCDPGEENSFFICDLGEVKRLFNNWVKELPRIKPFYAVKCNPDTKVLSLLAELGVNFDCASKVEIDRVLSMNISPDRIVYANPCKVASFIRYAASKNVMKSTFDNVEELHKIKKFHPESQLLLRIATDDSTAQCRLSTKYGCEMENVDVLLKAIKELGLNLAGVSFHVGSGASDFTSLYKAVRDARTVFDKAANEYGLPPLKILDVGGGFQFESFKESTAVLRLALEEFFPVGCGVDIIAEPGRYFVATAFTLASHVIAKRKLSENEAMIYTNDGVYGNMNCILFDHQEPHPRTLYHNLEFHYDDFESTTAVLDSINKTRSEYPYKVSIWGPTCDGLDCIAKEYYMKHDVIVGDWFYFPALGAYTSSAATQFNGFEQTADIVYIDSELD
Protein: Trophoblast glycoprotein (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (Wnt-activated inhibitory factor 1) (WAIF1) (Q9Z0L0)
Organism: Mus musculus (Mouse)
Function: May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MPGAGSRGPSAGDGRLRLARLALVLLGWVSASAPSSSVPSSSTSPAAFLASGSAQPPPAERCPAACECSEAARTVKCVNRNLLEVPADLPPYVRNLFLTGNQMTVLPAGAFARQPPLADLEALNLSGNHLKEVCAGAFEHLPGLRRLDLSHNPLTNLSAFAFAGSNASVSAPSPLEELILNHIVPPEDQRQNGSFEGMVAFEGMVAAALRSGLALRGLTRLELASNHFLFLPRDLLAQLPSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNALKVLHNSTLAEWHGLAHVKVFLDNNPWVCDCYMADMVAWLKETEVVPDKARLTCAFPEKMRNRGLLDLNSSDLDCDAVLPQSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV