wanglab/gogpt-training-data huggingface dataset:
Protein: Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (YNL) (Q91XA9)
Organism: Mus musculus (Mouse)
Function: Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme.
Subcellular location: Secreted. Cytoplasm. Cytoplasmic granule. Note=Detected in secretory granules of parotid acinar cells and gastric chief cells and secreted from them into saliva and gastric juice, respectively.
Interaction partners:
- Beta-hexosaminidase subunit alpha
- Beta-hexosaminidase subunit beta
- Chitotriosidase-1
- Chitinase-like 6
- N-acetyl-D-glucosamine kinase
- N-acylglucosamine 2-epimerase
- Transcriptional repressor CTCF
- Resistin-like alpha
- Arginase-1
Sequence:
MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
Protein: Ras-related protein Rab-13 (EC 3.6.5.2) (Q7T3A4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in endocytic recycling and may regulate the transport to the plasma membrane of transmembrane proteins. May regulate the assembly and the activity of tight junctions. May play a role in angiogenesis through regulation of endothelial cells chemotaxis. May be involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of glucose transporters.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P51153}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P51153}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, tight junction {ECO:0000250|UniProtKB:P51153}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P51153}. Recycling endosome membrane {ECO:0000250|UniProtKB:P51153}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9DD03}. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (By similarity). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250|UniProtKB:P51153, ECO:0000250|UniProtKB:Q9DD03}.
Interaction partners:
- MICAL-like protein 2a
- MICAL-like protein 1
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase catalytic subunit alpha
- Suppression of tumorigenicity 5.
- Rab GDP dissociation inhibitor
- Rab GDP dissociation inhibitor
- RAB3A-interacting protein
Sequence:
MAKKYDFLFKLLLIGDSGVGKTCLIIRFAEDNFNSTYISTIGIDFKVKTIEVEGKKVKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSYENIQNWMKSIKENASAGVSRMLLGNKCDIEAKRKVSKETGEKLAKEHGIRFFETSAKSSINVEESFTSLARDILLKSNKKPGPSGREVKLTSTEKKSSSKCLLL
Protein: Dystrobrevin-1 (Q9Y048)
Organism: Caenorhabditis elegans
Function: Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Syntrophin-1
- Dystrophin-1
- Alpha-catulin
- PDZ domain-containing protein
- Sarcoglycan complex subunit protein
- Beta-sarcoglycan
- Protein phosphatase 1 regulatory subunit 21 N-terminal domain-containing protein
- Dystroglycan-type cadherin-like domain-containing protein
- Dystrophin-like protein 1
- Dystroglycan 1
Sequence:
MLWSNGGGGPREPSSAPSPDHHRAMHSVPPIVASEMQQLIDEMRLQDFDSIRFATYRAACKLRFIQQKTKVHLVDIWNMIEAFRENGLNALPLHTVIKTSRAELLLTTVFHNLNKRLVASQHVDTDVSISLLLAFLLGAYDKQNTGRLTVFSIKVALATLCAGKLVDKLRYIFSQIADSNGLMDHIKFTDFLQQILSLTTAVFEAPTFGFSENAVNQCFHKDEKVSLNVFLDTFLSDPCPPCIMWLPLLHRMASVSNVYHPVVCDACQVRSFTGFRYKCQRCANYQLCQSCFWRGRTSQNHSNEHEMKEYSSYKSPTKQLVHSIHKSLQCIPATSTVGDANIDIFNAKIGGPVSSKPARPLNLNNIVPATPTTIRRQHAATSSADWPTSPVLLPGQASHGGVIDDEHKLIARYAAKLSGRADYPLSNGRSMNSSMVGDERTLIAQLEEENSMMVREMARLESQTTSDDGLAGLRDRKMELEEKMFEMQQRRRELMMQLEHLMAQLNTGPQPSGGVSSASLSQLPFTASDQQLTGVNSTVANAFRAGSLPATSLQGDLLHAADQITTNMSDLVRQLDLAQSDENGVTINGF
Protein: Growth hormone (G3CI04)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MMAAGPRTSLLLAFTMLCLPWTQVVGAFPAMSLSGLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTGKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDVTPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
Protein: CCAAT/enhancer binding protein zeta (A0A8I6AUW9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSADQEPLEFLAKNPWRPKEVTEDPDEEDEEDSDEAKNGFSLEEVLRLGGTKQDYLMLATLDENEEVVDGGKKGTIDDLQQGELEAFIQNLNLAKYSKSLIEEDEPEKKENTSKKEAKLPKVENKKQKAAEGKKKNKSALLLKPGGKWYDMEYSGEFSLEPQPWDVVSKYKALAEKLYEQEVGLFKNKTSNQKGGSSTWMKAIVSSGTLADRMAAMILLIQDDAVHTLQFVETLLSLVRKKGSKQQCLMALDTFKELLITDLLPDSRKLRLFSQRPLHKLEELSSGNKDSRDRRLILWYYEHQLKHLVAEFVQVLETLSHDSLVTTKTRALVAAHELLCDKPEEEKALLVQVINKLGDPQNRIATKASHLLEVLLRKHPNMKGVVCGELERLLFRSNISPKAQYYAICFLNQMVLSHEESELANKLITLYFCFFRTCIKKKDIESKMLSAILTGVNRAYPYSQIGDDRVREQVDTLFKVLHVVNFNTSVQALMLLFQVMNSQQTISDRYYTALYKKMLDPGLTTCSKQAMFLNLIYKSLKADIMLRRVKAFVKRLLQVTCTQMPPFICGALYLVSEILKAKPDLRSQLDDHPESDEENFVDVGDDSDDEKFTDADRETATDAVEEVEAKEAEPESSTETEKPKAASWVHFDNLKGGKQIKTYDPFGRNPLFCGAEHTNLWELRKLSQHFHPSVALFAKTILEGNHIQYSGDPLQDFTLMRFLDRFVYRNPKLHKGKENTDSVVMQPKRKHFMKNVRDLAVNSKEFLAKEESQIPVDEVFFYRYYKKVAVTKDKQKRNADEDSIEDVDDEEFENMIDTFEDDNCFTPGKDDMDFASNMKKIKGAKDDLEDSESSDDELGDLDDDEVSLGSMNDEDFEIDEDGGTFMDVSDDESDHVPEFGEASPKASTKKSKRKSEDDFDFAGSFQGQKKKKKSFNDSSLFVSAEEFGHLLDENMGSKFDTTGMNAMANKDNASFKQLKWEAERDDWLHNRDVKSIIKKKKNFRKKKAPQKPKRQRK
Protein: Protocadherin alpha 11 (Q91Y19)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MLSFQRRGSCTLPPLRWLLLLAAWEAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVRDINDNPPVFPLREQRLLISESKQPDSRFPLEGASDADIGENAVLVYRLSQNEYFSLEPPINSKQTKRPSLILKKVLDREKTPELNLLLTATDGGKPELTGTVQLWVRVLDVNDNDPVFDHLEYKVRIMENAAKETLVITLNATDLDEGANGQLVYSLMSIKPTGRHLFTLDEKNGELRVNGTLDYEENKLYEIEVLATDKGTPPMVGHCVVLVEILDTNDNSPEVTLTSLSLPVREDAQPNTVIALISVSDLDSGINGQVTCSLTPNVPFKIVSTFKNYYSLVLDSSLDRERVSTYDLVVIARDGGSPSLSATVSVSVEVADVNDNAPVFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVLDENDNAPTLLPHGAVGAGGAVSELVSRSVGSGHVVTKVRAVDADSGYNAWLSYEVQLGTGGVRSPFRVGLYTGEISTTRALDEVDSPRQTLLVLVKDHGEPALTATATVLVSLVESGQAPKSFSQASGRASAPEASLVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPMVNEATGGPGKPMLVCSSEVGSWSYSQQRRQRVCSGEVLPKTDLMAFSPSLPPNLGRDERERQESESSHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Protein: Probable sigma-70 factor, ECF subfamily (Q9I6Y3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable transmembrane sensor
- Probable TonB-dependent receptor
- Secretin/TonB short N-terminal domain-containing protein
- Probable sigma-70 factor, ECF subfamily
- Probable sigma-70 factor, ECF subfamily
- Probable transmembrane sensor
- Probable sigma-70 factor, ECF subfamily
- Sigma factor regulator, FemR
- Probable transmembrane sensor
- Probable transmembrane sensor
Sequence:
MPADGEAARRADLLKAFLAQRQRMESLVSRWVGCRATAADLVQELFLRFWRRPAAPVEELGSYLLRSARNLAIDHLRGEGSRQRQLDDWLPEQRQGEPVGPEQALEAGDQWRRVEAALRGLPERTRRIFLLNRIHGRTYAEIAQAMQLSQSAVEKHMMRALDACKASLAGPAGEQARSAQP
Protein: Transcription factor MYB106 (Myb-related protein 106) (AtMYB106) (Transcription factor NOEK) (Q9LE63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as a repressor of epidermal cell outgrowth and negatively regulate trichome branch formation. Acts as both a positive and negative regulator of cellular outgrowth. Promotes both trichome expansion and branch formation. Coordinately with WIN1/SHN1, participates in the regulation of cuticle biosynthesis and wax accumulation in reproductive organs and trichomes. Functions in cuticle nanoridge formation in petals and stamens, and in morphogenesis of petal conical cells and trichomes. May play a role in the regulation of cuticle formation in vegetative organs.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Ethylene-responsive transcription factor WIN1
- Transcription factor GLABRA 3
- Transcription elongation factor
- tRNA-specific adenosine deaminase TAD3
- ABC transporter C family member 1
Sequence:
MGRSPCCDKAGLKKGPWTPEEDQKLLAYIEEHGHGSWRSLPEKAGLQRCGKSCRLRWTNYLRPDIKRGKFTVQEEQTIIQLHALLGNRWSAIATHLPKRTDNEIKNYWNTHLKKRLIKMGIDPVTHKHKNETLSSSTGQSKNAATLSHMAQWESARLEAEARLARESKLLHLQHYQNNNNLNKSAAPQQHCFTQKTSTNWTKPNQGNGDQQLESPTSTVTFSENLLMPLGIPTDSSRNRNNNNNESSAMIELAVSSSTSSDVSLVKEHEHDWIRQINCGSGGIGEGFTSLLIGDSVGRGLPTGKNEATAGVGNESEYNYYEDNKNYWNSILNLVDSSPSDSATMF
Protein: Clarin 1 (Clarin-1 precursor) (Clrn1 protein) (Q6DGA8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Usher syndrome 1Gb
- Harmonin
- Cadherin-related 23.
- Whirlin
- Usher syndrome 2A
- PDZ domain-containing 7a.
- Calcium and integrin-binding family member 2
- Myosin VIIAa
- Whirlin b
- Protocadherin-related 15b.
Sequence:
MPNRQKQVIFSIAGVLCFGCVLVVAAAMGTQFWVQAAVLCKTGAQIVNASGAELGKFIGKANYGLFHGHGMKQCGLGDRPFYFSFFPDLMDVVPASLHVSVIFFCSVLIVFSSVCCGFFFYNAFGSPYETLHGPQGLYLWNMISSFCACLVLILFSSEVKLHHLTEIIFNFNEGSFVYKTHSECYDRSFWLIFLTFLLHGLNVLLIRLAGIQFPFQQAKESDASTGAADLMY
Protein: LOB domain-containing protein 14 (ASYMMETRIC LEAVES 2-like protein 17) (AS2-like protein 17) (Q9SJW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- LOB domain-containing protein 5
Sequence:
MGGLGSPCGGCKFLRRKCVEGCVFAPYFCYEEGSSNFAAIHKVFGASNFSKLISHLPDHDRCDAVRTISYEAHSRLHDPIYGCVSQIFSLQQQVVSLQAQVVLLREEASRRFPQDDPGCNMKQQEKVLAQQMPQDLHNWFHQGILDSDFDPMSGTTRDNERSMDHNESPCSSNESLNYYQEVNFPWSV
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (F1NW21)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane {ECO:0000256|RuleBase:RU000311}; Single-pass type I membrane protein {ECO:0000256|RuleBase:RU000311}.
Interaction partners:
- Neuropilin-1
- Vascular endothelial growth factor C
- Vascular endothelial growth factor D
- Cadherin-5
- Proto-oncogene tyrosine-protein kinase Src
- Vascular endothelial growth factor A
- Fibroblast growth factor 2
- Placental growth factor
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
- Cell division control protein 42 homolog
Sequence:
MELGPLRVLTVLLCLPPVFTGLFISMDQPTLSIQKSVLTITTNDTLNITCSGQRAVYWSWPNNQSSAEKRLAVTGCSDGPFCKTLTLLRVIGNDTGDYRCLYGDSQAATTIYVYVQDYRSPFVTSVGDQLGIVYITENKTVVVPCLGTVSNLNVSLHAKYPEKVFVPDGKSISWDNKKGFTIPSHLISYAGMVFCEAKIDNESYQSVIYIVVVVGYRIYDLTMNPHYQVELAVGEKLVLNCTVRTELNVGIDFKWDYPSIKEKRATIRDLKTTAGEIKTFVSTLTIDSVNLSDKGRYTCAASSGRMNMKNSSYFIIHESPFIHLEKMENVVEMKLGDTVSIPVKFKGYPSPEAKWYKNGKVMNANHTIKLGYTLVITDATEKDAGNYTVVLTNPTNKMQKRHTFTLLVNVPPQIGENALMAPVDSYKYGSTQTLTCTIYAVPPPAAVLWYWQLEEECTFSPQKVRLGANPYACRKWKVISERKGGNQVEIKQRVVTIAGKTKTVSTLVIQAANVSALYRCMATNRAGSSERVISFHVTRGLEINLQPRSQLTEKDNTSLQCTADKFTFEKLSWYKLSAHASQTPFGGLPMPVCKNLDALQKLNATVSNTNGENVTLELILRNISLQDGGDYVCIAQDKKAKTQHCLVKHLTVQEPMAPTLVGNLENQTTNIGETIEVSCTVNGIPPPNITWFKNGETLFEDSGIVLKDGNKTLTIRRVRKEDGGLYTCLACNILGCKKAEAYFSVEGAEEKTNLELIILVGTAVIAMFFWLLLVIILRTVKRANGGDMKTGYLSIIMDPDEVPIDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEYCKFGNLSAYLRSKRSEFVPYKTKSARFRQGKENYIGDISTDLKQRLDSITSSQSSTSSGFVEERSLSDVEEEDAGSEDLCKNPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSDNNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGDPKQRPTFSELVEHLGNLLQANVRQDGKDYVVLPLSVSLNMEEDSGLSLPTSPASCKEEEEVCDPKFHYDNTAGISQYRQGSKRKSRPVSVKTFEDIPLVTTVKVVQEENQTDSGMVLASEELKTLEERDKQVKIPFSTLAPSKSNESVMSEASNQTSGYQSGYHSDDMDTMVCSSEDTELLCAQEASPTLPRVHGLVHDSPAPLVSPPL
Protein: GH09980p (Papillote protein) (Papillote, isoform A) (Papillote, isoform B) (Papillote, isoform C) (Q9VYS2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSDQGPLLAKRGRHGLLAALLLICLAGQTAAQSNYVQHGDSGNYTTNGLPEEATLDGKVTKLDDISPLIFLNRTKAALNCAAGSMQVDLKFNDPFHGIIQADYDRSSACRVSGKGALSYRLELPLKGCGTIQNPTRVFTNNIIVRFHANLEMDGDEIITIVCRYPPPVPSLPPALPAPILNPIATSSVLQPPLKSIQILMIICAIMFLTLLLLGLAVSYYCLRSRSIPVVRRLPMSMGSGSEITKLSGSSVGNISAFEGVKIPRAHAALQAVYSSSGSEGALIPSDYPSESHSEIEEIDTRSLPFSSAGSFENRAFVHETSSIYSDHYAPAQEMPSANAVMTTTSVTRHSIPIQEAVAAVDSPKFDVQVRVKKSPPPPPSPVTSDTESVATLRPDRNNLSTIMEAYEDRESVLTMDSLPPQVETMHSQFTYVPELHPAPQVPQSIPLPPPAVVEPKFSVYTRTHHEVVDGRPETWSDYTDGPAPSEITDLSSEAPDMTVETMHYYEDEFMPAVEPPVTSHTVDDVYLRTVTEKKTIEDIESHKRRVTEYKSKPRAPLPPPPPPPQVDPKFDVRVRNYPGDREQQLWENFSDISSASGLTLTPKMERSELSLPPAELPAQIHDNKLKLTSPELVGNMKPIEVPPQDKDVPNWDVLIRILEEPEMSEVGQDDVSSVHNLTYDDRAKWKEIITTQSSLRTMLTEAVVREDFERIRQDTRYERMFEPQTWDVIIRILAPPGDDDPDVEMRTPRRGKKASPQPWDTRSRRSSLPTLYEYDSDGGSSVRTIRNDPGMSGVLMTGAGPGGAPGGPFNLQRSRRSSRTSYQTDHNDFRSMSEVTVDFGRPHQVDHPDNVSDASSYYRMQYYDDDDRRSFHRSLSHPSLARSASEFTEHWTAPDEMEVSSPEGTPHTRRARQPLSSQQVALATGRSGERVLSQTQTQSEYVETHRRVYHAEKEMPLPPRKW
Protein: Formin B (Formin, putative) (Q385J4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRFFSGWFSPRNVSLKQIADYPVYIWQIPCGKTSLDKNGKLVVSGTSTKDIKNTGGYLDSTHKECCMVFNFTPLLKELEAAFKHGEILDYSKQTIEDFTLLIELCSTIAKWALADRGRAGYCAVLVFFEESDAVHIPSYAAMIATCFYIFAGGQSYWGKYTLDYMEKQLGIPRSRYHFQSQEHYANYFQLLLDVPVVPSNKRRRLVRASLYNAEAIKDAKLSLLVQCEGEEFLIDDANAWEVVDDSVIHFDVPYPVCIFGDFAVVLLRNGKLLMEQMKKENVIARYAFSTIFVHEDNHQIHVRSMDYAEKNNLTGDFYITLHFVDGETRSTDSAYADQLRKRIDQSPRQKAFLLNPESFGAQNGYATSSSHRHDDDLMGGVYYRADGTQRGGHKHSGRMRSSSAAVREPAVLILEQEEERLYQDDEELASFAGSLYDEDDKCEQKTASHSSPRDPESSPLPPSATLPPPPPPAAERLPAPPPPPVKLPPPPPPPGGKLPPPPPPPPGGKLPPPPPPPGKAPPPPPGGKLPPPPPPGGKGAPPPPPPPPGKLGPGGGPPPPPPPPPRGLGSLGVSALGGPKAPVPKPAYVGPKLKTFFWKKLPRAMGLWSHADTAAVEKVIDENFLLGMFEVRKKSSTTMAKNSEAKAPKGNSLRMSTALTDQKRQNIAISLKKLKLSVGDLCRALIECNDEVLPCDVLESVYAAFPTTEEVASLRAEHTAGNVEWTDVERYMHELFSTVVDVRDRIPLWVATQTSVELVSFTEERLELIGRAVLAVTKRNSMLAALLHVILSIGNFMNRGSAHANAPGFRLESLNQMNFVKAVDGKTTMLEVVIVSVLDRDPGLLKFMDETECIEDICGTTIQDVGQSVSQLNFTLQKMRRAVEAANQLHLPGKIDAKLPPGVVDALPKVLQGYLEKYLAPVSQLAIRHQRLKEDIAEMLESFGEDPTMDETVFWNYFLQLRMEVGNILQRVEKEEVTKQSLLRSVGADGEGIGSKPEDSSKKE
Protein: Uncharacterized protein YHR173C (P38864)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Uncharacterized membrane protein YIL054W
- Uncharacterized protein YNL140C
- Uncharacterized protein YLR358C
- Uncharacterized protein YOR105W
- Uncharacterized protein YER084W
- Uncharacterized membrane protein YNL143C
- Uncharacterized protein YNL184C
- Uncharacterized protein YJR146W
- Dilute domain-containing protein YPR089W
Sequence:
MLFFFIYAWCHLSHTILQPSTKIQMIVRSKPESNGEKKLMNHDEPNDQYNQRNYPSEVYADLVSHFMNFAYGKVHESGLQKKGVRCVDVSISGCQFWNGIPLSASWCTSLVT
Protein: Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) (Q60648)
Organism: Mus musculus (Mouse)
Function: Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Has cholesterol transfer activity (By similarity).
Subcellular location: Lysosome.
Interaction partners:
- Beta-hexosaminidase subunit alpha
- Beta-hexosaminidase subunit beta
- Neuferricin
- Prosaposin
Sequence:
MHRLPLLLLLGLLLAGSVAPARLVPKRLSQLGGFSWDNCDEGKDPAVIKSLTIQPDPIVVPGDVVVSLEGKTSVPLTAPQKVELTVEKEVAGFWVKIPCVEQLGSCSYENICDLIDEYIPPGESCPEPLHTYGLPCHCPFKEGTYSLPTSNFTVPDLELPSWLSTGNYRIQSILSSGGKRLGCIKIAASLKGR
Protein: Threonine dehydratase, mitochondrial (EC 4.3.1.19) (Threonine deaminase) (O94634)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P00927}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable acetolactate synthase small subunit
- Threonine synthase
- Tryptophan synthase
- Acetolactate synthase, mitochondrial
- Dihydroxy-acid dehydratase, mitochondrial
- Serine hydroxymethyltransferase, mitochondrial
- Probable low-specificity L-threonine aldolase
- SUMO-conjugating enzyme ubc9
- Probable serine hydroxymethyltransferase, cytosolic
- Branched-chain-amino-acid aminotransferase, mitochondrial
Sequence:
MTGTSFYTSVLRLGRLAQQGLKFQSVKHIRPSCFSSFGLQAKRWNSTQQNDSSIDCLEPKLQGIIEDNISPSTAQKEISDIKFNIPKEMLLPDGTPDYLRLTLTSNVYEVIKETPLTKGVVISESTGVPVYLKREDLTPVFSFKIRGAHNKMASLDKQSLKNGVIACSAGNHAQGVAYSARTLGVKATIVMPQNTPEIKWRNVKRLGANVLLHGANFDIAKAECARLAKEQNLEVIHPFDDPYVIAGQGTIGLEILHQIDLRKLDAIYCAVGGGGLIAGIATYVKRIAPHVKVIGVETFDADALKKSLKDKKRVTLKEVGLFADGTAVKLVGEETFRLVSKNIDDVVLVDKDEICAAIKDVFLDTRSVVEPSGAMAVAGMKRYVAKHKPKNPNAAQVCILSGANMDFDRLRFIAERADLGLNKEVFLSVTIPERPGSFEALHNIITPRSITEFSYRYDNDDYANIYTSFVVKDRATELPLILQQISEQNMVAEDISDNELAKTHARYLIGGKSSVSKERLYRLDFPERPGALCKFLRSIKEVCSISLFHYRNCGGDIASVLAGLRVFDGQVEKLHSVLEEIGYNWVDETNNPVYLRYLRK
Protein: E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Macrophage erythroblast attacher) (D6RIB6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
Interaction partners:
Sequence:
MAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSGCPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYNTAVKLARQSGIETCKKALQPSRREPAGRGAPGHGHAGLPARHAHLPVQGPSGPCTVADADPAVPVRQLPTTPAGKQFCVHPHPAGWPLSHQDTCYKEDGSSKSPDCPVCSRSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEKVYIM
Protein: E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) (O42354)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome.
Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P23804}. Cytoplasm {ECO:0000250|UniProtKB:P23804}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P23804}. Nucleus {ECO:0000250|UniProtKB:Q00987}.
Interaction partners:
- Large ribosomal subunit protein uL5
- Cellular tumor antigen p53
- Protein Mdm4
- Large ribosomal subunit protein uL18
- Ubiquitin carboxyl-terminal hydrolase 7
- Retinoblastoma 1.
- non-specific serine/threonine protein kinase
- Checkpoint kinase 2.
- Androgen receptor
- non-specific serine/threonine protein kinase
Sequence:
MATESCLSSSQISKVDNEKLVRPKVQLKSLLEDAGADKDVFTMKEVMFYLGKYIMSKELYDKQQQHIVHCGEDPLGAVLGVKSFSVKEPRALFALINRNLVTVKNPESQSTFSEPRSQSEPDRGPGDTDSDSRSSTSQQQRRRRRSSDPESSSAEDESRERRKRHKSDSFSLTFDDSLSWCVIGGLHRERGNSESSDANSNSDVGISRSEGSEESEDSDSDSDNFSVEFEVESINSDAYSENDVDSVPGENEIYEVTIFAEDEDSFDEDTEITEADYWKCPKCDQFNPPLPRHCKSCWTVRADWLPETHSNWENLSRNTRTNPEDTSVTTTPNTTFEKKLSKPSSPLPETDDGVDVPTPPLLRRGSSQEETPELERFNSLEACLPATCLEPCVICQSRPKNGCIVHGRTGHLMACYTCAKKLKNRNKLCPVCREPIQSVVLTYMS
Protein: Vacuolar protein sorting-associated protein 52 homolog (Q8C754)
Organism: Mus musculus (Mouse)
Function: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q8N1B4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8N1B4}. Endosome membrane {ECO:0000250|UniProtKB:Q8N1B4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8N1B4}. Recycling endosome {ECO:0000250|UniProtKB:Q8N1B4}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex. {ECO:0000250|UniProtKB:Q8N1B4}.
Interaction partners:
- Vacuolar protein sorting-associated protein 54
- Vacuolar protein sorting-associated protein 53 homolog
- Vacuolar protein sorting-associated protein 51 homolog
- Syndetin
- EARP and GARP complex-interacting protein 1
- Syntaxin-16
- Ras-related protein Rab-6A
- Conserved oligomeric Golgi complex subunit 8
- Syntaxin-6
- Vesicle transport through interaction with t-SNAREs homolog 1A
Sequence:
MAAAATMAAAARELVLRAGASDVEEEEGPLGGGSGLQEPLQLGELDITSDEFILDEVDVHIQANLEDELVKEALKTGVDLRHYSKQVELELQQIEQKSIRDYIQESENIASLHNQITACDAVLERMEQMLGAFQSDLSSISSEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSALVTAILEAPVTEPRFLEQLQELDAKAAAVREQEAMGTAACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIPQAALLKYRFFYQFLLGNERATAKEIRDEYVETLSKIYLSYYRSYVGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKPSLRSRNTIFTLGTRGTVISPAELEAPILVPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFIVSGPAAHDLFHAVMGRTLSMTLKHLESYLADCYDAIAVFLCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSINQTIPNERTLQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEFIEELLSPPFGGLVAFVKEAEALIERGQAERLRGEEARVTQLIRGFGSSWKASVESLSQDVMRSFTNFRNGTSIIQGALTQLIQLYHRFHRVLSQPQLRALPARAELINIHHLMVELKKHKPNF
Protein: Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Q8A5W2)
Organism: Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00473}.
Interaction partners:
- Triosephosphate isomerase
- Pyruvate kinase
- Glucose-6-phosphate 1-dehydrogenase
- ATP-dependent 6-phosphofructokinase 2
- ATP-dependent 6-phosphofructokinase 3
- ATP-dependent 6-phosphofructokinase 1
- transketolase
- Enolase
- Probable transaldolase
- Phosphoglucomutase phosphomannomutase
Sequence:
MISLNIEKTFGFISKEKVSAYEAEVKAAQEMLEKGTGEGNDFLGWLHLPSSISKEHLADLNATAKVLRDNCEVVIVAGIGGSYLGARAVIEALSNSFTWLQDKKTAPVMIYAGHNISEDYLYELTEYLKDKKFGVINISKSGTTTETALAFRLLKKQCEDQRGKETAKKVIVAVTDAKKGAARVTADKEGYKTFIIPDNVGGRFSVLTPVGLLPIAVAGFDIDKLVAGAADMEKACGSDVPFAENPAAIYAATRNELYRQGKKIEILVNFCPKLHYVSEWWKQLYGESEGKDNKGIFPASVDFSTDLHSMGQWIQEGERSIFETVISLDKVDHKLEVPFDEANLDGLNFLAGKRVDEVNKMAELGTQLAHVDGGVPNMRIVLPELSEYNIGGLLYFFEKACGISGYLLGVNPFNQPGVEAYKKNMFALLNKPGYEEESKAIQAKL