wanglab/gogpt-training-data huggingface dataset:
Protein: Scribbler, isoform J (A0A0B4KEU2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Grunge, isoform J
- Six-banded, isoform H
Sequence:
MESMRRNEANTSHHPNKVALNSSNVATESNIKNNKLLANLSAAGAATATTATTGTATTTTATTANQALNFNNKTKATANATAASANNRHNNNNNSSAIKKHTNTKQLAGKSPACNSSSSSLSSSSSSNSSESKDTNFEYEDEWNIGGIPELLDDLDADIEKSAHSSGGGNQATALNAKQANSSSTSSSSSSKGGASSSSSSAAATGSSSSHKSHKTTLHSNLSATSPTTIKFTRQPVAIGGANSSSSSSAAAAPSGGSANVVAKGSSSSSSSTSSSSSGKHHHHHHHHSNSSSSGSSSKGYKSALVAQLNSPSPLNSNSKSLSGSGSGSGNTNGAAGAGAGSTLSSSTFAGFSKGGSLVSSSAGAAAALAAGSGQQGSKFSAGGMSSQTGSGSGGNNTSNSNNSSSGSGGSGSGSSTGNTASGSGNNNSTSAGGPPSSQGGNNGNGSGSSSSSSSGKSSAKMSIDHQATLDKGLKMKIKRTKPGTKSSEAKHEIVKATDQQQNGALGAGSNNSANEDGSSGSSSTNASSLGSTNSSSSASSGSSSSSGSSSSSSKKHLNNASSGSGSSSSGGGSQNNASGHASGGGSSGSSQSTPQGTKRGSSGHRREKTKDKNAHSNRMSVDKSAAAASAAGEKDTPEKCSGTGAGGSPCSCNGDVGAPCSHHACIRRAAHMSNSAGNANSSAGTGQSGGSSSMSAVPPGVFTPSAGSPSTGSPSTVVPAAASLLAATGAASSSASQMASSSAGGVGGSGGGANAPGPPGKESAGSIKISSHIAAQLAAAAASNSYSGSGANTNQGQNSNAGGNGGSESKAAAAAQAKLMAPGMISATMHHTISVPAGTGTGDDDTKSPPAKRVKHEAGASGAGGGKEMVDICIGTSVGTITEPDCLGPCEPGTSVTLEGIVWHETEGGVLVVNVTWRGKTYVGTLLDCTRHDWAPPRFCDSPTEELDSRTPKGRGKRGRSAGLTPDLSNFTETRSSIYFSHAQVHSKLRNGATKGRGATRSASGNAAANSNSSSSGNGGGATPSTSPTAFLPPRPEKRKSKDEAPSPLNGDASDGASVGGIGGAGGVNMVNASGIPISASGGGLATQPQSLLNPVTGLNVQISTKKCKTASPCAISPVLLECPEQDCSKKYKHANGLRYHQSHAHGAGGGASSMDEDSMQAPEDPATPPSPGVASGTGSGASVASSAVPATAPSAGQGTVAVSPNTPLANSSNPVTNGNVAPSAPATGSVTIAAPNTTPSVVETQAPLTGPPPVTPPAPTPICAVATPGAEQSVSSVLPLGNLPLTAGPNSATQQQQPPTQQQQPQLLVPGGSAASLQQQQQQQQPVAGGSITAGISGQALSQHQQQLMGGLPAMLSDQQQQALLQQGALKAGVLRFGPPDGNPLQQQPGQASVNPQTQQSPPRPPSHVQDQQTPSAYAQQAGLKTSPGFGSVGVGAASSKQKKNRKSPGPSDFEGRVSREDVQSPAYSDISDDSTPVAEQEMLDKSVGQAVTAKHIELMGKKPTEVGVGVPPPPAPNMYVPGMYQFYPAQQQSAPPPQQQQQQPQYMVQTEPGKPPGLPPALTQAQQQQQLQPGAPPPTSQPPSHLLGPPGQQSVAAHLADYSGKNKDPPLDLMTKPQPQPGQPPSQQQQSGQLSGQENNGKDVGPPTSQPGSQPPPVNLSAVAGPPPGSLPPGLGGLSALGAAGLGGPGPGKGMPHFYPFNFIPPAYPYNVDPNFGSVSIVASEEAAKLSGHPGLPPSSQAQQLSGISIKEERLKESPSPHDQPKHMPSQQQMIASKLIKQEPMTKQEIKQEPNSNPGQQHPPPQQQPAPQPQQQQPPPPQPQQPHALHPKDLQALGAYPAIYQRHSINLAVQQAREEELRRYYMFTGRQNSAAAAAAAAAQNAASGGLPPHPGMMHKDEPGMGSAAQQQQQQQQQQMQIAQQQQQAIQQHHQHLQQQHQAQQQQQQQQHQQQQQQQQQQQQQQQQQQQQQKLKQSQAASAGANNKATNLTKDSPKQKGGDDDQPLKVKQEGQKPTMETQGPPPPPTSQYFLHPSYISPTPFGFDPNHPMYRNVLMSAAGPYNTAPYHLPIPRPYHAPEDLSRNTGTKALDALHHAASQYYTTHKIHELSERALKSPTSGSGPVKVSVSSPSIGPPQPGGPTSSGPGSGPVSGVLGPGSGSNQQPGSAPGSAGGVPLNLQPPPGGMGPSPGSKPDLSGPKGHGGVTPGSSLDGHKQSMPGGPPPNGPSGNGAVGGVGGAAGNGAAGGGGAGAADSRSPPPQRHVHTHHHTHVGLGYPMYPAPYGAAVLASQQAAAVAVINPFPPGPSKXDPLNGNNEKKAYNVKNN
Protein: Bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 1 (EC 5.1.3.2) (EC 5.1.3.5) (UDP-D-xylose 4-epimerase) (UDP-L-arabinose 4-epimerase) (UDP-galactose 4-epimerase 1) (UDP-glucose 4-epimerase 1) (PsUGE1) (B0M3E8)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Catalyzes the interconversion between UDP-glucose and UDP-galactose and the interconversion between UDP-arabinose and UDP-xylose.
Interaction partners:
Sequence:
MVASSQKILVTGGAGFIGTHTVVQLLNNGFNVSIIDNFDNSVMEAVERVREVVGSNLSQNLEFTLGDLRNKDDLEKLFSKSKFDAVIHFAGLKAVGESVENPRRYFDNNLVGTINLYEVMAKHNCKKMVFSSSATVYGQPEKIPCVEDFKLQAMNPYGRTKLFLEEIARDIQKAEPEWRIVLLRYFNPVGAHESGKLGEDPRGIPNNLMPYIQQVAVGRLPELNVYGHDYPTRDGSAIRDYIHVMDLADGHIAALRKLFTSENIGCTAYNLGTGRGSSVLEMVAAFEKASGKKIALKLCPRRPGDATEVYASTAKAEKELGWKAKYGVEEMCRDQWNWAKNNPWGYSGKP
Protein: Uncharacterized protein orf165 (Q2F960)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MLGKALSPLCFVSFYLSSSLDETSTSMKAPPTTPPYPSHSSFRWSFIYPLIVLGTTIARSREFTGQTMSIEKGGSGGLVSVLRFTSTHFRTNRNLAIRTLHSISLASIHLFCSIIHQLLSYNSLSLAFSFVLRWNRTTEGFQGQCPLLFPLKQAKKDLQSFALTS
Protein: GATA zinc finger domain containing 2B (A0A0U1RR34)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLKMLALLKRKDLANLEVPHELPTKQDGSGVKGYEEKLNGNLRPHGDNRTAGRPGKENINDEPVDMSARRSEPERGRLTPSPDIIVLSDNEASSPRSSSRMEERLKAANLEMFKGKGIEERQQLIKQLRDELRLEEARLVLLKKLR
Protein: Calcium/calmodulin-dependent protein kinase type II (CAM kinase II) (EC 2.7.11.17) (O42844)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in the regulation of G2/M transition during the mitotic cell cycle.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12135745, ECO:0000269|PubMed:12589433}. Barrier septum {ECO:0000269|PubMed:12589433}. Forespore membrane {ECO:0000269|PubMed:12589433}. Ascus epiplasm {ECO:0000269|PubMed:12589433}.
Interaction partners:
- Calmodulin
- Mitogen-activated protein kinase sty1
- Myosin 1 light chain cam2
- Vacuolar protein sorting-associated protein 41
Sequence:
MSILAGFKNLLKHSKSSKGRSNASKSVDVSVNRDVAAYTELAAKNVNAGGDEEIRVANYPGLEKYQLIENLGDGAFSQVYKAYSIDRKEHVAVKVIRKYEMNKKQRQGVFKEVNIMRRVKHKNVVNLFDFVETEDFYHLVMELAEGGELFHQIVNFTYFSENLARHIIIQVAEAVKHLHDVCGIVHRDIKPENLLFQPIEYLPSQNYTPPSLEPNKLDEGMFLEGIGAGGIGRILIADFGFSKVVWNSKTATPCGTVGYAAPEIVNDELYSKNVDMWAMGCVLHTMLCGFPPFFDENIKDLASKVVNGEFEFLSPWWDDISDSAKDLITHLLTVDPRERYDIHQFFQHPWIKGESKMPENFTYKPKLHGTPGGPKLSLPRSLVSKGEIDIPTTPIKSATHPLLSSYSEPKTPGVSSVHEAMGVAYDIRRLNHLGFSPEQLSKKSMNTGSIKELILDEETTTDDDDYIISSFPLNDTLGSEGKDPFSLNLKESSLYSRRSAKRVN
Protein: Internalin B (InlB) (Invasion protein InlB) (P0DQD2)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Function: Mediates the entry of L.monocytogenes into normally non-phagocytic mammalian host cells. Its host receptor is hepatocyte growth factor receptor (HGF receptor, a tyrosine kinase, MET) which is tyrosine-phosphorylated in response to InlB. Downstream targets MAPK1/MAPK3 (Erk1/2) and AKT are phosphorylated in response to InlB, which also causes cell colony scattering. Complement component 1 Q subcomponent-binding protein (gC1q-R, C1QBP) has been suggested to also act an InlB receptor, but this is less certain. Stimulation of Tyr-phosphorylation of MET by InlB is potentiated by the InlB GW domains and glycosaminoglycans such as heparin (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P0DQD3}. Cytoplasm {ECO:0000269|PubMed:11929538}. Cell membrane {ECO:0000269|PubMed:11929538}. Note=Approximately half the protein is secreted. Cell surface association is mediated by the GW domains and can occur when protein is added externally; externally added protein confers invasion competence. Protein is partially buried in the cell membrane; it binds non-covalently to lipoteichoic acid (LTA) on the bacterial membrane, and can be released from the surface by LTA. {ECO:0000250|UniProtKB:P0DQD3}.
Interaction partners:
- Listeriolysin O
- Internalin A
- Zinc metalloproteinase
- Phospholipase C
- Actin assembly-inducing protein
- Listeriolysin regulatory protein
- 1-phosphatidylinositol phosphodiesterase
- Uncharacterized protein Lmo0206
- Lmo1290 protein
- Lmo1289 protein
Sequence:
MKEKHNPRRKYCLISGLAIIFSLWIIIGNGAKVQAETITVPTPIKQIFSDDAFAETIKDNLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKPLANLKNLGWLFLDENKVKDLSSLKDLKKLKSLSLEHNGISDINGLVHLPQLESLYLGNNKITDITVLSRLTKLDTLSLEDNQISDIVPLAGLTKLQNLYLSKNHISDLRALAGLKNLDVLELFSQECLNKPINHQSNLVVPNTVKNTDGSLVTPEIISDDGDYEKPNVKWHLPEFTNEVSFIFYQPVTIGKAKARFHGRVTQPLKEVYTVSYDVDGTVIKTKVEAGTRITAPKPPTKQGYVFKGWYTEKNGGHEWNFNTDYMSGNDFTLYAVFKAETTEKAVNLTRYVKYIRGNAGIYKLPREDNSLKQGTLASHRCKALTVDREARNGGKLWYRLKNIGWTKAENLSLDRYDKMEYDKGVTAYARVRNASGNSVWTKPYNTAGAKHVNKLSVYQGKNMRILREAKTPITTWYQFSIGGKVIGWVDTRALNTFYKQSMEKPTRLTRYVSANKAGESYYKVPVADNPVKRGTLAKYKNQKLIVDCQATIEGQLWYRIRTSSTFIGWTKAANLRAQK
Protein: Altered inheritance of mitochondria protein 19 homolog (Q9UUF4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cardiolipin synthase
- Nuclear control of ATPase protein 2
- ATPase synthesis protein 25
- Probable T-complex protein 1 subunit beta
- Aconitase-ribosomal protein bL21m fusion protein
- Protein mmf1, mitochondrial
Sequence:
MENKELRKSYFQRIYQSYIPAYAFGGALIASVPRAFKRPYGGPFVPGCLLCGGFNAIGGLAIASGDLTNGSGICTAWSIAYLMINATKSIKSFRLYPIALTTFATANAVGYGKTFMNEY
Protein: ATP-binding cassette sub-family C member 12 (Multidrug resistance-associated protein 9) (Q96J65)
Organism: Homo sapiens (Human)
Function: Probable transporter, its substrate specificity is unknown.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17472575}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
Sequence:
MVGEGPYLISDLDQRGRRRSFAERYDPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVRL
Protein: Dro3 protein (Q2UYD4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MVQIKFLFAILAVMTIVLMEANTVSARDCLSGTFGGPCWAWSGEKCRRLCIEEGHVSGHCSGGMKCWCEGC
Protein: LMBR1-like membrane protein (Q57XX2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLNWWLIVLIVVCSLLCLAIAIYVLYYFSSEDDHEGSYLTKVIIVFGILLAIGVVLLLPFDASNARDPTVGSKYVNTLNTDLMWEIVLWSLAVMALVVVPFTVFFYEAYDPDDESFSKQCGQAITLTLIVSFVFIVITAVCFLSFGTALVPVELYEALPQIVDDIDRVSYNTTSDKDKFEVHVSIFTYVVGELCLVGWIAFFFYAGVGLVSVPVDLIRGFINRPKPISGSTFAQEMAVIAAKGDTLLSVALALQNEARGKVPRSMRNKISFLRAETHVLEEEQEELIWNYKKVGGSPFIVYGKLLIGILSVALSISWVLQIFLHNTFKIVPFLSTLVTALDEVFPLFGIITYGIFAFYLVWITLEGQIRVGLRFVFFQIHPMKPHDTTLNSIVFNVGLLLLTSYAILQFTTRSFNEYIPRTSINALMNLYVMNLKGIGVAVEWAQFCLLGVSFLGLLFVLACPAKNAAARPKKPNYST
Protein: RH61449p (Q8MR96)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY
Protein: Protein doublecortin (DdDCX) (Q550F6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Has a cytoskeleton-independent function in chemotactic signaling during development.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21034843}. Note=Associated with microtubules and actin.
Interaction partners:
- Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein
- Uncharacterized protein
- Probable myosin light chain kinase DDB_G0271550
- Probable myosin light chain kinase DDB_G0292624
- Probable myosin light chain kinase DDB_G0275057
Sequence:
MTSTSGKPKMEKFGLQTDKSARVILFRNGDRYHVEGVHCLVHSSKFKTFDQLKLEFSKKVGLFTGNVQKVYSMDKKRIQDIKDFVDGHHYICCGAEPLNTEVIPKGIQDIFGKAEVSDQDDEPKPSKPFVSSVPPPPTPTPTSSSGTTTTSQPTLSASPSVSSAQSPKKPVVSAYKESAVHSIDKFSVQTEKAKVIMCFRNGDRYHSGERVTVHSTKFKTYDQLKEQLSKQVKLPTGPVRKLYLASSGKLVKTMEEIIDGEYYVCAGGETLNPLDFSPTLSEHVKQKKLQEQQQQASEQQKPQEQEIF
Protein: Lamin-like protein in HindIII repetitive element derived DNA, 3' end (Q14755)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
TQHTRISGTHLKPVYRGKFIALNAHKRKQERAKIDTLTSQLKELEKQERANSKASRRQEITKIRAELKEIETQKTLQKTNESRSWFFERINKIDRPLARLIKKKREKNQIQSIKNDKGDITTNATEIQTTIREYYKHL
Protein: GLI-Kruppel family member 2b (Zinc finger protein GLI2b) (Q5BN24)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEAGVPAPAEKKDCKSSPLEGNVFSEMPKKPSPSSLSRGPHHIFPTFHSPIPIDVRHHEGRYHYDPHALHALHGPPGLAGSPVISDISLIRLSPGAAGEAFLPPHSYVSPHVEHYLRSAHSSPTLSMISAARGLSPAEVAHEHLKERGLFGLPPPPGASPADYYHLMAGHRNPYGELLMQGAGAAAAAAHLPEYFTSVDVSRFPSPRMTPRLSRKRALSISPLSDASIDLQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVGGISPSFPFPHSINPVAYQQLLTQQRGLSAFGHTPPLIQPSPTFSSRHPLSLSTLPTPTTNDTETKNSNGESAVSSTVNPLGNKRSKVKTELGGPRPVSPYSPEHLSSAQDLKEDMDDCKQEAELVYETNCHWEGCSKEYDTQEQLVHHINNEHIHGEKKEFVCRWDECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDLPSRPHPPKENGENEAGAKMAEEKIEANSTTRGVEDYLQVKSIKTENSMMYQSSPGGQSSCSSEPSPLGSASLHGGGVEPAGLSGGSVGDLSALDDVPIVDSTVSTGILGLHLRKNAGPAHRLTHLKQEKLKSVRDSCSWANTAPPAPCTKLPPINTGSLLDGLCDPGLSISSPRLGDLCPGETTVLSQLVERRDSLASTVSSAYTFSRRSSGISPCYSSRRSSQTSQPGGRHNNISSADSYDPISTDLSRRSSEASLYGGIFSLTPAQHYRLKAKYAAATGGAPPTPLPNIDCKTLLGDSHEIPIHPPLVPRRCSDTGYANRSVLPHEVTANITRRASDPVRRIAAERHSLYNSVNPYPTLHPLASSRHFYSTSESNVNRQQYPPRAPSISENVMMETLPDDMESCNGVEDGLMMADDAVQCITTQNADSPQHTGVAHRNQSFGSPQHCHLQRRLALVEGNMNAVARQTASSQQTFPGSANATKIPMPVQWNEVSSGTVDSSRSQTKQGSGRGNLQQKQNLSSFLNVNSNQQVGLMSHNLALSPVQRSVEFNSLRINQRQANAEFLHGYLQGSASNDISLGLLNPSGKSLTVQPGGVQNNRVCAQAQSHATFPNNQGNYSQMSSNQQGYIVASQNVNGNLLLQPRPPTEPKPYSTQHSGPTTTAAQSNFSPAYDTSEASPKKSSSMFYTGQIHMFDSSGAMPCPSSVGSPETNQVSSTVDSSGADPPQIDFDAMLDDGDHSSLMSGTLSPALLRSLSQNSSRLTTPRNSVTLPPVAAGISNMAIGDMSSMLTALAEESKFLNMMS
Protein: DUF4200 domain-containing protein (Q385W2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSNALESITAATQLRRAVMEAQRELDAKRELYLTRMARAHEIEETIAQGRAKLQDKLVRYYKFIQDNEVKRSRAMRKAVTEERIRKEREAQVEELTKKLQNLHDRSEELRGLYDVYSRYQRYLEEVLQRNDSDEYQGPRDIIQRWNTLHENTKVLQRRKTQLEEELLRNKNALNVKRQRKNNESVQLQNQLNELQARFGQLQKNIKIKQDELERCISQRSTTSRTISHVRMACKNLYDRCITWTAPYSGRGKFESREADVLFQLHVIGDCLRDFQDVIEAHHQRQQQLALARASRDDDA
Protein: AMP-binding domain-containing protein (O45873)
Organism: Caenorhabditis elegans
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
- Fatty acid synthase
- Nsp1_C domain-containing protein
- NADP-dependent oxidoreductase domain-containing protein
- Mechanosensory protein 2
- Papilin
- Tubulin alpha-3 chain
- Protein mtd-1
- Tubulin beta-1 chain
- Mechanosensory abnormality protein 6
- Degenerin mec-10
Sequence:
MEIQNPFQISWDKTAAQSFHDYFFSKISAHGSNLAIVDVDSGKQWRYSEIRNWCEMCATRLKELQVTSGSRVAVITGTTGQAIFVHLACSIIGCSAVAVNGWNAVDEIWTLVDLSEATHLIVENQFMQKADDVRRKAQMRGGGRIKHVRQIEDVLTAERINVDSARKRSIDVKQKPPLVKEMSLAKINLTPVLPEDIADLTSPVSEVSGQSKELNGDVESSVVDSEEVQTPIQQVSGQNPLLILFTSGTTGLAKAAELSHRSLIINIQQISLPLYGPVQTKERFLLPLSIAHIYGIVSAYYALINGASLYLISKQSNRLFMETLVNNQINVMHITPAIVHWMATDAIVDDYKTPNLRSVLCAGAPIDSNSAAAMKSRLNIKDFRQSFGMTELGGICTMSPYLDEKIESVGNPLPGMLFKVVNWETKQLCLPRQPGQIIVLGPQVSPCYYKNPKATSELFDATGFVKTGDAGFYDEVGRIYVLDRIKDIIKCKGTMICPSEVELVLRAHAGIDDCAVVGRQDHVTGEVPAAFVVKNAQHPLLASAEVRQYVSGKIATFKELRGGVFFISEIPRSVCGKILRRNLRQFWDRERTNSKVDSLTNKDGAKTAGAAKGAPAKKVNGSTTPSRRPPSAGRPVKK
Protein: DNA polymerase sigma-like protein (Q57WQ6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSASDGGRSSKRSGNGWSRVKRWSANVPATYVEGTQMLTVDGAQQTAVVNPSWNRGYNPADCAWTREGGLKRHRTGDNNAEDRRLRHKSKMSTLCPKTEPLGSSNMPFDSEGIHTFDEGLLSFLAAVAPDEEAHRKARLVMHDVAQTLYNVGLQVALFGSWSTGLCIPSSDMDFAAVSVIPHVAGRTNNSNMFRRNYEYGGSCGMVTESLFASLSDPPEFKRERQRNYSLALRTVAKSMRSSNSFCRIVCIPHARVPLVKAVHSCGKAVDVSFQSDGLKTTAFLRDEFRREEFRRARGLIMLLKALLDKWELNDPSKNGLGSFPVSIMVLWFLREEAPKECTGESGNNYATQFVALLKYYGTQFDYLKEGIDYAKGCTFTKTSTELFIVNPLKPGANCASSATLFDSRVVPNLREAYRDLLPLLKPNVTACLIERTLGRVFGVSQKALSRGKAMWKHRQDARAYVGGATAQHQWDELTNMYVGNPIGV
Protein: High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha) (P12319)
Organism: Homo sapiens (Human)
Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8114916}; Single-pass type I membrane protein.
Interaction partners:
- High affinity immunoglobulin epsilon receptor subunit gamma
- High affinity immunoglobulin epsilon receptor subunit beta
- Tyrosine-protein kinase SYK
- Tyrosine-protein kinase Fyn
- Mast cell carboxypeptidase A
- Immunoglobulin heavy variable 4-38-2
- Tyrosine-protein kinase Lyn
- B-lymphocyte antigen CD20
- Immunoglobulin alpha Fc receptor
- Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Sequence:
MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
Protein: Tetrapyrrole-binding protein, chloroplastic (Genomes uncoupled 4) (Q9LX31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates chlorophyll synthesis and plastid-to-nucleus signal transduction by binding both the product and the substrate of Mg-chelatase, an enzyme that produces magnesium-protoporphyrin IX (Mg-Proto). Activates also Mg-chelatase. Neither binds abscisic acid (ABA) nor is involved in ABA signaling.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:12574634}; Peripheral membrane protein {ECO:0000269|PubMed:12574634}. Note=Might be bound to membranes by specific protein-protein interactions.
Interaction partners:
- Magnesium-chelatase subunit ChlH, chloroplastic
- Magnesium-chelatase subunit ChlD, chloroplastic
- Magnesium protoporphyrin IX methyltransferase, chloroplastic
- Glutamyl-tRNA reductase 1, chloroplastic
- Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic
- Heme oxygenase 1, chloroplastic
- Pentatricopeptide repeat-containing protein GUN1, chloroplastic
- Magnesium-chelatase subunit ChlI-1, chloroplastic
- Chlorophyllide a oxygenase, chloroplastic
- Glutamyl-tRNA reductase 2, chloroplastic
Sequence:
MATTNSLHHHHHSSPSYTHHRNNLHCQSHFGPTSLSLKQPTSAATFSLICSASSTSSSTTAVSAVSTTNASATTAETATIFDVLENHLVNQNFRQADEETRRLLIQISGEAAVKRGYVFFSEVKTISPEDLQAIDNLWIKHSDGRFGYSVQRKIWLKVKKDFTRFFVKVEWMKLLDTEVVQYNYRAFPDEFKWELNDETPLGHLPLTNALRGTQLLKCVLSHPAFATADDNSGETEDELNRGVAVAKEQAGVGADKRVFKTNYSF
Protein: Charged multivesicular body protein 1, isoform A (Charged multivesicular body protein 1, isoform B) (GH26351p) (Q95SH2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- IST1 homolog
- RH72336p
- Vacuolar protein sorting-associated protein VTA1 homolog
- vesicle-fusing ATPase
- GH14561p
- Charged multivesicular body protein 4
- Charged multivesicular body protein 5
- Charged multivesicular body protein 2b
- Vacuolar protein sorting 20, isoform A
- Vacuolar protein sorting-associated protein 28 homolog
Sequence:
MSTSSMEKHLFNLKFAVKELERNSKKCEKEEKLEKAKAKKAIQKGNMDVARIHAENAIRQKNQAVNYLRMSARVDAVASRVQSALTTRKVTGSMAGVVKAMDAAMKGMNLEKISSLMEKFESQFEDLDVQSSVMEGTMSDTVTTSVPQGDVDNLLQQVADEAGLELNMELPSGVQSQSVGASTAVSQEQDELTQRLARLRQAE
Protein: Ubiquitin-conjugating enzyme E2 7 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 7) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase) (Q02159)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Involved in resistance to cadmium poisoning.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Anchored via the membrane protein CUE1 to the endoplasmic reticulum membrane.
Interaction partners:
- UBX domain-containing protein 2
- Coupling of ubiquitin conjugation to ER degradation protein 1
- ERAD-associated E3 ubiquitin-protein ligase DOA10
- ERAD-associated E3 ubiquitin-protein ligase HRD1
- ERAD-associated E3 ubiquitin-protein ligase component HRD3
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 4
- Protein OS-9 homolog
- Ubiquitin-conjugating enzyme E2 6
- Nuclear protein localization protein 4
Sequence:
MSKTAQKRLLKELQQLIKDSPPGIVAGPKSENNIFIWDCLIQGPPDTPYADGVFNAKLEFPKDYPLSPPKLTFTPSILHPNIYPNGEVCISILHSPGDDPNMYELAEERWSPVQSVEKILLSVMSMLSEPNIESGANIDACILWRDNRPEFERQVKLSILKSLGF
Protein: Aldo-keto reductase family 1 member C18 (EC 1.1.-.-) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Q8K023)
Organism: Mus musculus (Mouse)
Function: Catalyzes the conversion of progesterone into 20-alpha-dihydroprogesterone (20 alpha-OHP).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
- Steroid 17-alpha-hydroxylase/17,20 lyase
- steroid 11beta-monooxygenase
- Polyprenal reductase
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6
- Cytochrome P450 11B2, mitochondrial
- Steroid 21-hydroxylase
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3
Sequence:
MNSKIQKIELNDGHSIPVLGFGTYATEEHLKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVLLDDPVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFPADMFKAHPNFPFFDEY
Protein: RING-type domain-containing protein (Q383W3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGNAPSFCCCCFPFFSQRRADQDHQQAARGEARRSQFSLPLRRRCGVCGMYIDPVLFDGHREACRENNFRNLRQQQQGELQDLGDDCSRDYDTEEWCVVCFAARRSFAFLPCGHVSCCEKCVMALQFCPLCREPRAALCRVATGLLLQFKCRHCGEIIAPELHDGHREVCGFRMMLLQKGKDVSKEEDGSDGADGPSDRCAISNAEDTSATTCLNADAVLTTSGECVTKSTMQYCIQCHGVERPLVIMLPCGHRLLCEVCCSGRKTCPVCLQCIESSVKSFC
Protein: MKIAA1312 protein (Q69ZM2)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
RNAQSIPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEDGSVADESACATLPKPVAKEECSVTPCGQWKALDWSSCSVTCGQGKATRQVVCVNYSDHVIDRSECDPDYIPETDQDCSMSPCPQWTGLAHPFQNEDFRPRSDSPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGSWGECTKLCGGGMRTRLVVCQRANGDRFPDLSCEVLDKPTDREQCNTHACPQDAAWSTGPWSSVRT
Protein: Transcription factor Sp6 (Krueppel-like factor 14) (Q3SY56)
Organism: Homo sapiens (Human)
Function: Promotes cell proliferation (By similarity). Plays a role in tooth germ growth (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Lipase member N
- Acrosomal protein SP-10
- Proprotein convertase subtilisin/kexin type 5
Sequence:
MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAASGEGKAGGAVEPPGGKGKREAEGSVAPSN