wanglab/gogpt-training-data huggingface dataset:
Protein: G1/S-specific cyclin-E (O01501)
Organism: Caenorhabditis elegans
Function: Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of seam cell daughter cells. Involved in the progression of cell division in the intestinal lineage in larvae, and in particular in endoreplication, a specific growth pathway in the intestinal epithelium, required for feeding and gut development in growing larvae. By controlling the activity of translational repressor gld-1, regulates the pool of germline stem cells and the size of the mitotic zone by preventing entry into meiosis. In addition, repression of expression by gld-1 prevents mitosis re-entry in meiotic germline cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:12606285}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:17115027}. Note=Co-localizes with cdk-2 in the sperm centrioles before the first embryonic mitosis and then to the male and female nuclei upon entry into mitosis. {ECO:0000269|PubMed:12606285, ECO:0000269|PubMed:17115027}.
Interaction partners:
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase inhibitor
- Cyclin-dependent kinase inhibitor 1
- Retinoblastoma-like protein homolog lin-35
- Cyclin-dependent kinase 4 homolog
- M-phase inducer phosphatase cdc-25.1
- Cyclin-dependent kinase 1
- rRNA biogenesis protein RRP5
- Cell division control protein
- TATA-box-binding protein
Sequence:
MAGRKSSRTAERVPTTQKPERKSAILSPHDELRERLLETAIDMKENIPQRNTRNSSVGSQKSDCSETRKRRSTKEGPAAKRHSGEKHRNGSREDSLEYISEYSDDREVGSSSSQSSRTRGQPLPAMPEEEEVFDKSSSSDNLAESEESHEMVRLEERQDIEEEIEDDFDDEEEDVVNDKEEYEEIESEDEDDYPVQNEGFAVTKRLMNDEHMVTAPTFLSTAKCDGIGSPTKVWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVECSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGWSLGPITSIQWLSTYLQLLGTGKKNKSDHYEEQNMYVPELLRSEYLEMCKILDFLLFEIDSFTFSYRTIAAAVLFVNYEPTCAVEKATGFMQAQLEKVIEYVEPVCRAFAKQRQLLDDVIPKHESIKSDDSHNIQVYVKRSSMEPIVKSERERIQHLKARRLHPQRLF
Protein: Pappa2 protein (Q505G3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLLNFSSPLVGISAVALRTSSQTSSSAPSNCIPEQNYEGKSCAQRPCGEQGRCAPLLLDHTDMVNCTSSSPGHMECAITCQRGYVLQTSSGQYLRNMQKEILLTCSSGHWDKDVICKRLDCGVPDSSLVNYANFSCLEGTDFLKQCSISCVPPAKLQGLNPWLTCLEDGLWSLPEVYCKLECEAPPVIPNANLLLPHFLEGNHDVGTICKYECKPGYYVKETSGSQGKNKFLKIQCLDDGSWEQGSCVPVVCEPPPPVFEGMYECTDGFKLDSQCVLNCNQETEGIPILCTKEGLWTQEFKLCENLQGECPPPTSELNSVEYKCGQGYGIGAVCSPSCVIPSSDPVILPENVTTDTLEHWMEPVKVQSIVCTGRRQWHPDPSLVHCIQSCEPFQADGWCDTINNRAYCNYDGGDCCSSTLSSKKVIPFAADCDLDECTCRDPKAEENQ
Protein: tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (Q57WH7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- arginine--tRNA ligase
- phenylalanine--tRNA ligase
- isoleucine--tRNA ligase
- Elongation factor Ts, mitochondrial
- phenylalanine--tRNA ligase
- glycine--tRNA ligase
- Tyrosyl/methionyl-tRNA synthetase, putative
- Bacterial surface antigen
- Valine--tRNA ligase, mitochondrial
- proline--tRNA ligase
Sequence:
MTTNTADVGSVEERFKLIRSVGEECIQENELRAMLEKKPDIRCYDGFEPSGRMHVAQGVFKSINVNKCTQSGCEFVFWVADWFALMNDKVGGELQRIRIVGEYLTEVWKAANMNMERVRFLWSSDEITNNANTYWKLVLDISRRNTIARIKKCCTIMGKQEGTLTAAQVLYPLMQCADIFFLKADICQLGLDQRKVNMLAREYCDLIGRKNKPVILSHHMLAGLKQGHAKMSKSDPDSAIFMEDSEEDVARKIRAAYCPRVAQKSTEVTDDGAPVASEDKNPVLDYFECLVFSKPGATAVVDGAEYNTYADLEKAFVDGNISEEALKEGLIELLNGILEPVRKHFVEDPHAASLLQQVLSFRAGGAAPPLSAVPLPEQSATPLAVAWLPACIKFPVDLAVALSDAIKQFLRENTDGEAVLLLPEWTAMACNNVGGEEKYISAALELNAAILKSHWLPSERVRIVRQSEMILANPNDYWLTAINVGRKNKLQRVEEVCGDLKNAGAVVAALMYVADAAMLKATHAICTSHDRGCHEIATDFYEGKLRVIPALGGVVPPLSNAEPPVSETLASGPVNKDDILFIDDTDMDMRRKIKRAYCAPNEDANPVLSIATWLMREQGALLIERTEANGGDVAYKGEGQLRADALSGALHPADLKQAVSKMLLDKCAAAKAVLSTAEGKKYAQTLKNAEKSLSKSK
Protein: Duplicated homeodomain-like superfamily protein (Q9M0P7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAFPQWTRVDDKRFELALLQIPEGSPNFIENIAYYLQKPVKEVEYYYCALVHDIERIESGKYVLPKYPEDDYVKLTEAGESKGNGKKTGIPWSEEEQRLFLEGLNKFGKGDWKNISRYCVKSRTSTQVASHAQKYFARQKQESTNTKRPSIHDMTLGVAVNVPGSNLESTGQQPHFGDQIPSNQYYPSQENFRGFDQRW
Protein: Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein homolog) (Transmembrane protein 16E) (Q75UR0)
Organism: Mus musculus (Mouse)
Function: Does not exhibit calcium-activated chloride channel (CaCC) activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17418107}; Multi-pass membrane protein {ECO:0000269|PubMed:17418107}. Cell membrane {ECO:0000269|PubMed:17418107}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with CALR/calreticulin. Shows an intracellular localization. {ECO:0000250|UniProtKB:Q75V66}.
Interaction partners:
- Dysferlin
Sequence:
MVEQEGLTAKEIDYAFQQNENLGSKETSFLIPEDLQSPPEKRFNLFLRRRLMFQRSEHSKDSVFFRDGIRQIDFVLSYVEDLKKDGELKAERRREFEQNLRKTGLDLETEDKLNSEDGKTYFVKIHAPWEVLVTYAEVLGIKMPIKLSDIPRPKYPPLSYMLGAVKLPSSVKYPTPEYFTAQFSRHRQELFLIEDEATFFPSSTRNRIVYYILSRCPFGVEEGKKKIGIERLLNSNTYLSAYPLHDGQYWKPSKTTRPNERYNLCKNWARFSYFYKEQPFHLIRNYFGEKIGIYFVFLGYYTEMLLFAALVGLACFIYGLLSMENNRTSTEICDPDIGGQMIMCPLCDEVCDYWRLNTTCLHSKFSHLFDNESTVFFALFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEFEAMCKHKKMNPVTKEMEPHMPLCHRIPWYFVSGTTVTFGMALLLSSMVSILIYRLSVFATFASFMESEATLQSVKSFFTPQLATALSGSCLNCIVILILNFFYEKISAWITKMEIPRTHQEYESSLTLKMFLFQFVNYYSSCFYVAFFKGKFVGYPGSYTYMFNIWRSEECGPAGCLIELTTQLTIIMIGKQIFGNIHEAFQPLIFNWWRRRRARTHSEKLYSRWEQDHDLQVYGHRGLFYEYLETVIQFGFATLFVASFPLAPLFALMNNIMGIRVDAWKLTTQYRRPVAAKAHSIGVWQDILFGMAIVSVATNAFIVSFTSDIIPRLVYFYAYSTNSTEPLSGYVNNSLSVFLIADFPNHTVPMEKKDFVTCRYRDYRYPPDHEDKYSHNMQFWHVLAAKMTFIIVMEHVVFLFKFLLAWLIPDVPKDVVEKIKREKLMTIKIIHDFELNKLKENLDVEYGNIMKNVLVDEDNSLKAKTTV
Protein: Zgc:123271 (Q32PR9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVDKGPLLTSAIIFYLSIGAAIFQVIEEPNWEIAVRKYRADKESILKQYPCLTKADLDYILEVVSDAAGQGITITGDKTFNNWNWPNAVIFAATVITTIGYGNIAPKTPSGRVFCIFYGLFGVPLCFTWISELGKFFGGRAKHLGWYLTKKGVTLRKTQLTCTAVFLLWGVLIHLVIPPFVFMTQEGWTYIEGLYFSFVTLTTIGFGDLVAGVDPNAEYPTLYRYFVEVWIYLGLAWLSLFFNWKVRMVVEAHKALKKHRKRRRLSLDELQLKESHKTLHLPPTPNDVNIFSFLSKKKEGYNDLIKQIGADKGENQCVSTMNSRKNAAAKRSKSCSDALSINGNTIVSLDGSPRLKRHYSFSDRVAVALSKSKGYLFSQEECLLMTEKLEEGDTDSQCMGMSENQLDKEAGESHKALISEGCRNSQITWDSKGHQTNMFPNANITFIDEDNFVNNNREDENDFMPSFKSDEPDFRKEEDSESETSVFTGCGSDHGQSYERLVEEYSKEDNTDI
Protein: Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) (O96626)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in the rapid activation and adaptation of the actin system to its multiple functions.
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, cell cortex. Cell projection, pseudopodium.
Interaction partners:
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 1
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 3
- SPIN90/Ldb17 leucine-rich domain-containing protein
- WASP-related protein
- Wiscott-Aldrich syndrome protein
Sequence:
MNYEDDNVESGQAGKSDAEYKADIANREKEVTKALNAGKPQDALNVALADPPIYTKTGAIKDQNATIVLNLLGSFKDKDVETSVETLNDDQLDILMKYVYRGLATGENSPIFFKWHECVLKKGGAGTIIRVISEKKTV
Protein: Bone morphogenetic protein 4 (O57574)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MIPGNRMLMVILLCQVLLGESSYASLIPEEGKKKASALHLAQSHELLRDFEATLLHMFGLQRRPRPSHSAVVPQYLLDLYRLQSGELEEAGAQHVSFDYPERSTSRANTVRGFHHEEHLEELQSDGSQETPLRFVFNLSSIPEDELISTAELRVYRQQIDDAFSDPDQTGDHGLHRINIYEVLKAPREGQLITQLLDTRLVRHNTSKWESFDVSPAVLRWTQEKRSNHGLAVEVVQMKRNPVQKGRHVRVSRSVHPLPDEEWDQLRPLLVTFGHDGKSHPLTRRAKRSPKQRGRKRNRNCRRHALYVDFSDVGWNDWIVAPPGYQAYYCHGECPFPLADHLNSTNHAIVQTLVNSVNTNIPKACCVPTELSAISMLYLDETDRVVLKNYQEMVVEGCGCR
Protein: Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45) (Q9NRW7)
Organism: Homo sapiens (Human)
Function: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with Golgi/endosomal vesicles and the trans-Golgi network. {ECO:0000250}.
Interaction partners:
- Syntaxin-16
- Rabenosyn-5
- Ras-related protein Rab-5A
- Syntaxin-6
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 18 homolog
- Vam6/Vps39-like protein
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Vacuolar protein sorting-associated protein 33A
- Vesicle transport through interaction with t-SNAREs homolog 1A
Sequence:
MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNREIMKHLKAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYRKLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEEVLASGLHSRSKESSQVTSRSASRR
Protein: feruloyl esterase (EC 3.1.1.73) (Ferulic acid esterase A) (Q2U7Y9)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- Synaptobrevin homolog YKT6
Sequence:
MRFLSGFVSVLSSVALLGYAYPTAIDVRDIPTTQLEDFKFWVQYAAATYCPNNYVAKDGEKLNCSVGNCPDVEAAGSTVKLSFSDDTITDTAGFVAVDNTNKAIVVAFRGSYSIRNWVTDATFPQTDPGLCDGCKAELGFWTAWKVVRDRIIKTLDELKPEHSDYKIVVVGHSLGAAIASLAAADLRTKNYDAILYAYAAPRVANKPLAEFITNQGNNYRFTHNDDPVPKLPLLTMGYVHISPEYYITAPDNTTVTDNQVTVLDGYVNFKGNTGTSGGLPDLLAFHSHVWYFIHADACKGPGLPLR
Protein: Translation initiation factor eIF2B subunit beta (GCD complex subunit GCD7) (Guanine nucleotide exchange factor subunit GCD7) (eIF2B GDP-GTP exchange factor subunit beta) (P32502)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a regulatory component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2. It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD6 and GCD7 repress GCN4 expression at the translational level by ensuring that ribosomes which have translated UORF1 will reinitiate at UORF2, -3, or -4 and thus fail to reach the GCN4 start site.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9UT76}.
Interaction partners:
- Translation initiation factor eIF2B subunit epsilon
- Eukaryotic translation initiation factor 2 subunit alpha
- Translation initiation factor eIF2B subunit alpha
- Eukaryotic translation initiation factor 2 subunit beta
- Translation initiation factor eIF2B subunit delta
- Eukaryotic translation initiation factor 2 subunit gamma
- Translation initiation factor eIF2B subunit gamma
- Protein MUK1
- Protein DSS4
- eIF-2-alpha kinase GCN2
Sequence:
MSSQAFTSVHPNAATSDVNVTIDTFVAKLKRRQVQGSYAIALETLQLLMRFISAARWNHVNDLIEQIRDLGNSLEKAHPTAFSCGNVIRRILAVLRDEVEEDTMSTTVTSTSVAEPLISSMFNLLQKPEQPHQNRKNSSGSSSMKTKTDYRQVAIQGIKDLIDEIKNIDEGIQQIAIDLIHDHEILLTPTPDSKTVLKFLITARERSNRTFTVLVTEGFPNNTKNAHEFAKKLAQHNIETLVVPDSAVFALMSRVGKVIIGTKAVFVNGGTISSNSGVSSVCECAREFRTPVFAVAGLYKLSPLYPFDVEKFVEFGGSQRILPRMDPRKRLDTVNQITDYVPPENIDIYITNVGGFNPSFIYRIAWDNYKQIDVHLDKNKA
Protein: Superoxide dismutase [Mn] (EC 1.15.1.1) (MnSOD) (P00448)
Organism: Escherichia coli (strain K12)
Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Interaction partners:
- Superoxide dismutase
- Catalase HPII
- Catalase-peroxidase
- Alkyl hydroperoxide reductase C
- Redox-sensitive transcriptional activator SoxR
- Regulatory protein SoxS
- DNA-binding transcriptional dual regulator OxyR
- Aconitate hydratase A
- Alkyl hydroperoxide reductase subunit F
- Glutathione reductase
Sequence:
MSYTLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPVEELITKLDQLPADKKTVLRNNAGGHANHSLFWKGLKKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAASRFGSGWAWLVLKGDKLAVVSTANQDSPLMGEAISGASGFPIMGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAAKK
Protein: T-box transcription factor TBX6 (T-box protein 6) (XTbx6) (Q8AV66)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional activator. Plays a role in ventral mesoderm specification and acts together with nog during muscle differentiation. Mediates posterior pattern formation of the embryo, including specification of posterior mesoderm, via activation of the Wnt and Fgf signaling pathways.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Interaction partners:
Sequence:
MYHSELFQQYGTSYTMRPPHALAPTYPSAGGHHDSYRYSELDVPSQRFDGLFPALEPSQRILGAPPLTPLSLPPGPALGFGQVQPPCETPQLPGNVKMKLENKELWKQFHSIGTEMIITKSGRRMFPQCKVSVSGLEADGKYLLLADLLPVDNSRYKWQEDHWEASGRAEPRLPERVYIHPDSPAPGSHWMKQPISFHKIKLTNNTLDQMGHIILHSMHKYQPRFHIVRAQDVFSRRWGGCSSFTFPETLFLTVTAYQNEKITQLKIQTNPFAKGFREDGMKSKRDRSIRGKRKVISVEQEQEEEEQFQPEGECKRPPLYSGPCDSTLSEELDIGRSLGIPSPNCSFHPITPPTQTPPSTETPNPSLPANQEQGAPLQMSSQTPGTFLQTYPEPPRGASSLYSCSPTDAAQNQTLRPSAQRLPPGYQESPHISHSQGELKIYGTEMGPPGNFNPPSCAVTPSVRLSDEPMGRGFSMNFPHFLPNNKIGLQISGAQLQRMYNGGGWM
Protein: NAD(P)-binding Rossmann-fold superfamily protein (Putative oxidoreductase) (O80924)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGIYGVMTGKKGKSGFGSASTAEDVTQAIDASHLTAIITGGTSGIGLEAARVLAMRGAHVIIAARNPKAANESKEMILQMNPNARVDYLQIDVSSIKSVRSFVDQFLALNVPLNILINNAGVMFCPFKLTEDGIESQFATNHIGHFLLTNLLLDKMKSTARESGVQGRIVNLSSIAHTYTYSEGIKFQGINDPAGYSERRAYGQSKLSNLLHSNALSRRLQEEGVNITINSVHPGLVTTNLFRYSGFSMKVFRAMTFLFWKNIPQGAATTCYVALHPDLEGVTGKYFGDCNIVAPSKFATNNSLADKLWDFSVFLIDSISK
Protein: Uncharacterized PPE family protein PPE42 (P9WHZ5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Elicits a high humoral and a low T-cell response. Could be involved in directing the host toward development of a more humoral type of immune response.
Interaction partners:
- ESX-1 secretion-associated protein EspE
- PE-PGRS family protein PE_PGRS30
- PE-PGRS family protein PE_PGRS28
- PE-PGRS family protein PE_PGRS16
- PE-PGRS family protein PE_PGRS15
- PE-PGRS family protein PE_PGRS43
- Uncharacterized protein Rv2209
- Probable membrane protein
- Phthiocerol dimycocerosate exporter MmpL7
- ESX-1 secretion-associated protein EspK
Sequence:
MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGSFASVTTGLAGDAWHGPASLAMTRAASPYVGWLNTAAGQAAQAAGQARLAASAFEATLAATVSPAMVAANRTRLASLVAANLLGQNAPAIAAAEAEYEQIWAQDVAAMFGYHSAASAVATQLAPIQEGLQQQLQNVLAQLASGNLGSGNVGVGNIGNDNIGNANIGFGNRGDANIGIGNIGDRNLGIGNTGNWNIGIGITGNGQIGFGKPANPDVLVVGNGGPGVTALVMGGTDSLLPLPNIPLLEYAARFITPVHPGYTATFLETPSQFFPFTGLNSLTYDVSVAQGVTNLHTAIMAQLAAGNEVVVFGTSQSATIATFEMRYLQSLPAHLRPGLDELSFTLTGNPNRPDGGILTRFGFSIPQLGFTLSGATPADAYPTVDYAFQYDGVNDFPKYPLNVFATANAIAGILFLHSGLIALPPDLASGVVQPVSSPDVLTTYILLPSQDLPLLVPLRAIPLLGNPLADLIQPDLRVLVELGYDRTAHQDVPSPFGLFPDVDWAEVAADLQQGAVQGVNDALSGLGLPPPWQPALPRLF
Protein: SNARE-binding exocyst subunit (Q5A7K3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Exocyst complex component SEC15
- Exocyst complex component SEC5
- Exocyst complex component Sec8
- Exocyst subunit
- Exocyst complex component EXO84
- Exocyst complex protein EXO70
- GTP-Rho binding exocyst subunit
- Ras-related protein SEC4
- Rcy1p
- Protein transport protein SEC9
Sequence:
MSDSTLSKISELIKLEDDLAKIGSIRQQFLKEKSSVDVKLSSTTQVQIDSIMKNLANLHNTMERLDSIKGSIGEVQQVHDSTIGEVREYDTIKKMTMVNQFLHQVGSLYEDISGFKRFVEALNEEIQRELQGLQNDLKYPLPNFVRIHHAYTQARNFVDYLEVYSTRLSDDLQSIVYKVVSPIKTTIKLFDELLNEGIQSLTEVTKEGNFECFFNILGVVTWEENEDLKVSLLKSLDMVSADPKTVNYKTFRGRSRNYKKFFFDKLRTHLYEIFDSCVEYYGNDKILVYDGLYWLEDEMRFVYTTLDKLFPANWGVSAFIQDVYYNRLHDFTMDLINTDPPAEDLLKILSYDSKYGAFVSEFGVKQKSIIGEELKNSVLDDYLNNITTKMKEWNDNLIRQETKTFTERPNAPDIYPIESTIEDLDADKNEVQLTIDLNVYVMPDFKIALTMLKEQADVAAESKYSRILVEVIESWSECYVKRIANFREVVEDEMDRYMSVFNNEGYLIKESKAKRLFRKKPPVVDIDSLSPEEQSKLSREGLIEYLAALANSLDISDDIMNDKFAPTYKEKVHTNYHARIGKAFDVASESSNALISEILSAITDIIMNDLTPALCKLFTKKWYEDGHSQTGEPTLAKLVVETISEYMGEMRQYCVYPVYQLLFVIFLDNFIPTYIRIGYENILHGDGKKIDPQATKKYKSFSEGITRDIEIFFSGLDPLFTRKDGEYFFASLNAIELLSVLGTVEVNNIKDVWQHEVLPKFYDCSVEYIRGVCLCRKDMDKSETKQLVSQLQEIKVEYHQAVQPPDVPIFTLNDFEFQD
Protein: STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) (O95630)
Organism: Homo sapiens (Human)
Function: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Subcellular location: Nucleus {ECO:0000269|PubMed:17261583, ECO:0000305|PubMed:10383417}. Membrane {ECO:0000269|PubMed:17261583}; Peripheral membrane protein {ECO:0000269|PubMed:17261583}. Cytoplasm {ECO:0000269|PubMed:17261583}. Early endosome {ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583}.
Interaction partners:
- Signal transducing adapter molecule 2
- Signal transducing adapter molecule 1
- Charged multivesicular body protein 3
- Charged multivesicular body protein 1b
- Charged multivesicular body protein 2a
- RNF103-CHMP3 readthrough
- Polyubiquitin-C
- Charged multivesicular body protein 1a
- Growth factor receptor-bound protein 2
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRAVTITDLR
Protein: Chaperonin Hsp60, mitochondrial, putative (Q586A7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 10 kDa heat shock protein, putative
- Heat shock 70 kDa protein, putative
- Heat shock 70 kDa protein, mitochondrial, putative
- GrpE protein homolog
- Uncharacterized protein
- CCT-theta
Sequence:
MLYSTRRLASAAGKAIHFGGEARERMLNGIERIATAVGVTLGPKGRNVIIRQPSGEPKITKDGVTVAQSIEFNDQFEDVGARLIRQVAGKTNDIAGDGTTTATILAWSIFAEGYKCVATGANPMDLKRGIDIAVDVLLKSLSEQKRPVKDLQMLENVATISANGERSLGALIARVVQSVGVNGYIAVLSGNGSATEWMRYDGWSVEQGFVSSALVTNTTELKSSLESPFIFITAEKLESVHDVLRLLGAAKNSGKPLVLVAPQFSEAVLQTVIHNHVNNVVLCGIVCAPELSEEELHDLATCCQCRVEKVGSLGVVDDVTCLLGRAERWEQTMDSTVVAGVADAAPRVRLLQGRLERALTEDVKEKLRERISKLNRTFAVIRVGGRSTVEINESKDRVIDAVNAARNALAEGIVAGGGAALLHASKQLDVLMREDEDMEQDRRTGILIVRNAARLPMKRISENAGEEGAVTVETVAEYEDCCMGYDAQNDRYVDMFEVGIVDPVKVVNSCVVDAASVAGLMITTEASVCDFKEERRQRDSG
Protein: Glycogen debranching enzyme (EC 2.4.1.25) (EC 3.2.1.33) (Glycogen debrancher) (D4AEH9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Glycogen phosphorylase, muscle form
- Glycogen phosphorylase, brain form
- Glycogen phosphorylase, liver form
- 1,4-alpha-glucan branching enzyme
- Phosphoglucomutase-1
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogenin-1
- Alpha-amylase.
- Pancreatic alpha-amylase
- Phosphoglucomutase 2-like 1
Sequence:
MEHSKQIRILLLNEMEKLEKTLFRLEQGFELQFRLGPTLQGKAVTVYTNYPFPGEAFNREKFRSLDWENPTEREDDSDKYCKVHLQQSGSFQYYFLQGQEKSGGGYIVVDPILRVGADNHVLPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHFTPLQALGLSRSCYSLADQLELNPDFSRPNRRYTWDDVGQLVEKLKREWNILCITDVVYNHTAANSKWIHEHPESAYNLVNSPHLKPAWVLDRALWHLSCDVADGKYREKGVPALIENDHHMNCIRKIIWEDIFPRIQLWEFFQVDVQKAVEQFRRLLSQENRRVTKSEPKEHLKIIQDPEFRRLGCAVDMNIALATFIPHDNGPAAIEECCNWFRKRLEELNSEKHHLTSCHQEQAVNCLLGNVFYERLAGHGPKLGPVTRKYPLVTRYFTFPFEEMALSAEESLLHRPDKACFLMAHNGWVMGDDPLRNFAEPGSNVYLRRELICWGDSVKLRYGNKPEDCPYLWAHMKKYTEITATHFQGVRLDNCHSTPLHVAEYMLDAARKLQPNLYVVAELFTGSEDLDNIFVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQPCLRPLMPAIAHALFMDITHDNECPIVHRSAYDALPSTTVVSMACCASGSTRGYDELVPHQISVVAEERFYTKWNPGASPSDTGDVSIHSGIIAARCAINRLHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIHQSVVAVSRTAFRNPKTSFYSKEVPQMCIPGKIEEVVLEARTIERNTKPYRKDENSINGMPNMTVELRERIQLHESKIVKQAGVATKGPNEYIQEIEFENLSPGSVIIFRVSLDPHAQVAVGILRNHLTQFSSHFKSGSLAVDNSDPILKIPFASIASKLTLAELNQVLYRCESEEQEDGGGCYDIPNWSSLKYAGLQGLMSVLAEIRPKNDLGHPFCENLRSGDWMIDYVSGRLISRSGSIAEVGKWLQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLDVAWKQMSSFVQNGSTFVKHLSLGSVQMCGVGKCPCLPLLSPSLLDVPCRLNEITKEKEQCCASLAAGLPHFSSGLFRCWGRDTFIALRGMLLVTGRYLEARNIILAFACTLRHGLIPNLLGEGTYARYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPLFEVIQEAMQRHMQGIQFRERNAGPQIDRNMKDEGFNITVGVDEETGFVYGGNRFNCGTWMDKMGESDRARNRGIPATPRDGSAVEIVGLCKSAVRWLLELSKKNIFPYHEVRVRRHGKVVAVSYDEWNRKIQNSFEKLFHVSEDPSDPNEKHPNLVHKRGIYKDSYGASSPWCDYQLRPNFTIAMVVAPELFTAEKAWKALEIAEGKLLGPLGMKTLDPDDMVYCGVYDNALDNDNYNLARGFNYHQGPEWLWPIGYFLRAKLYFSKMMGPETAAKTVFLVKNVLSRHYVHLERSPWKGLPELTNENGQYCPFSCETQAWSMAAVLETLYDL