wanglab/gogpt-training-data huggingface dataset:
Protein: Regulator of G-protein signaling 12 (RGS12) (O14924)
Organism: Homo sapiens (Human)
Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.
Subcellular location: Nucleus {ECO:0000269|PubMed:10869340}. Cytoplasm {ECO:0000250|UniProtKB:O08774}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08774}. Synapse {ECO:0000250|UniProtKB:O08774}.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus matrix {ECO:0000269|PubMed:12024043}. Note=Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains. {ECO:0000269|PubMed:12024043}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
- Rho guanine nucleotide exchange factor 1
- Guanine nucleotide-binding protein G
- Rho guanine nucleotide exchange factor 11
- Guanine nucleotide-binding protein subunit alpha-13
- Beta-adrenergic receptor kinase 1
- Regulator of G-protein signaling protein-like
Sequence:
MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGVLHMVIAEGVGRFESCSSDEEGGLYEGKGWLKPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASNSEPLKLKQRSLSESAATRFDVGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDDFALDASILNVAMIVGYLGSIELPSTSSNLESDSLQAIRGCMRRLRAEQKIHSLVTMKIMHDCVQLSTDKAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALRTSCHVFMVDPDLFNHKIHQGIARRFGFECTADPDTNGCLEFPASSLPVLQFISVLYRDMGELIEGMRARAFLDGDADAHQNNSTSSNSDSGIGNFHQEEKSNRVLVVDLGGSSSRHGPGGSAWDGVGGRGAQPWGAPWTGPFCPDPEGSPPFEAAHQTDRFWDLNKHLGPASPVEVPPASLRSSVPPSKRGTVGAGCGFNQRWLPVHVLREWQCGHTSDQDSYTDSTDGWSSINCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKREWSRKAFGMQSIFGPHRNVRKTKEDKKGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITRSLDDLESATVSDGELTGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSVSSAGSLDLSEACRTLAPEKDKATKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSSRNHSATGEERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADDQRGLLRKEDLVLPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQWEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWKRQSQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTPQEVPGPSRPGSGTHGSRDLPVNRIIDVDLVTGSAPGRDGGIAGAQAGPGRSQASGGPPTSDLPGLGPVPGEPAKPKTSAHHATFV
Protein: Probable sulfite reductase [NADPH] flavoprotein component (EC 1.8.1.2) (Q09878)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate (By similarity).
Interaction partners:
- Sulfite reductase subunit beta
- Probable phosphoadenosine phosphosulfate reductase
- Homocysteine synthase
- Cysteine synthase 2
- Sulfate adenylyltransferase
- Cysteine synthase 1
- Probable uroporphyrinogen-III C-methyltransferase
- Adenylyl-sulfate kinase
- Siroheme biosynthesis protein met8
- Probable cystathionine gamma-synthase
Sequence:
MVATDSSDQVAKFDVSHKIIEDIVYSLSNRIFSYAEHVPLNRYLTQWNNSGRRNGFSNNVELFNLEARSGASAFLLGSYTAAISSPGVYSMMTPSSCLSLLNPLLSNIIPFYGASKPLVVHVAALAYLEQTYCADNVSVLDFSYANNFTVFASQSNVEAAHLALASTLAAKAAPVIHVYEPDAIVTTTDPSLPLLDSNAVVECFNSYQSEADPVSNASKALKHVNDYFNTSYAPAEYYGSQTASKVIVTFGKSETVAARALLAANPDVGVLSIRIFPFVAENIFNVLPTTCKSLVVLSQVRSTAVGTSSIYYSFLLATLLSTKPSALAISEHRYSLVESVTLSSLFDALHETLQLKAATPKAVHVDKSINVWESDVGDSLVLSLVSAYRTDKSRSVAFRPLFDNLTLAGVRFTVAQVSTANAVLTDVVKDVDADITILTTDRLPLHYRVLAKAAEHSICLLQSSIAPDEATKKLPYEFIADALEKGVKLVLIDPKKFAIDASNLPLLVSFIQLVKPGLGVDEALAVLAKQNNLTDTNLKDAVDSLKQSLSFINLDASALKDREPSEKELPSTAKETSFAPNAVKTLDEDITPQSSNWQTVAKQIIFPEAYKKKDALRPDVSEKVFTVHVRANKRLTPAEYNRNIFHIEFDLGDSGLTYDIGEALGVYGVNNKTHVHDFIEEYGLDANELIHVPSIQHPGHWETRTVFQALCQNIDIFGKPTKKFHEQLLEFETDEKERADLQILISPAGAPDFKRRAEVDMLTYADVLKEFKHAKLTAAQIAQIVPVIKRREYSISSSQKKHNDSVHLLVVVVGWKDGMGRDRYGQCSHYLSNLKVGEPLCVAVKTSVMKLPTSPLKPIVMAGLGTGLAPFRAFLQFKEWQRMQGIESGDILLYLGSRTQREEYLYGEDWEAYHSANLLTHIGQAFSRDQPYKIYIQDVMRSTKDMLKKALMDEGGSFYLCGPTWPLPEITSVLEEVIQSSYDEPVDARKIIEQWKEERRFVIEVY
Protein: Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase) (P22830)
Organism: Homo sapiens (Human)
Function: Catalyzes the ferrous insertion into protoporphyrin IX.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22315}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22315}; Matrix side {ECO:0000250|UniProtKB:P22315}.
Interaction partners:
- Protoporphyrinogen oxidase
- Frataxin, mitochondrial
- ATP-binding cassette sub-family B member 10, mitochondrial
- Mitoferrin-1
- 5-aminolevulinate synthase, erythroid-specific, mitochondrial
- Uroporphyrinogen decarboxylase
- Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
- Porphobilinogen deaminase
- Heme oxygenase 2
- Heme oxygenase 1
Sequence:
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL
Protein: Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase (FIB) (EC 2.1.1.-) (P58032)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
Interaction partners:
- Pre mRNA splicing protein
- Large ribosomal subunit protein eL8
- K Homology domain-containing protein
- Small ribosomal subunit protein uS4
- tRNA
- Elongation factor 2
- GTP binding protein, hypothetical
- Large ribosomal subunit protein eL19
- Large ribosomal subunit protein uL3
- Translation initiation factor 6
Sequence:
MSEVITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYKG
Protein: Rho guanine nucleotide exchange factor 9 (Collybistin) (Rac/Cdc42 guanine nucleotide exchange factor 9) (A0A1B0GWI5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}.
Interaction partners:
Sequence:
MSVALAAPHASARSRSLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK
Protein: Peptidase S49 domain-containing protein (Q54YA6)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Fructose-bisphosphate aldolase
- Transketolase
- Probable 2-ketogluconate reductase
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- Glucose-6-phosphate isomerase
- Enolase-phosphatase E1
- RNase H type-1 domain-containing protein
- Uncharacterized protein
Sequence:
MSKIIHNLQNIELDSLKKLGEVTKYLNEHPMLRSFLISTGLIVTSKLIKLIKNRIRNNTILEIDFTNTIDTSDVDISPIEKLLDPNIISFRSLLDAIEKAANDKRVIGLIVRLSGENQFSLANIQEFRNAISFFKSKGKRTVAFTDSFCEAGSGIGRYYMASIFHDVYMAPSGTLNLINTQYDFAFIKKTLEKLNIVPDTITRKEYKNALSGLVNEHLTEPEKESMNAIFKSLYEQIIEDIAKDRSLTKERVNELFESGPFSSDKALVNKLVDSTLYGDEVYTTTYEKLETTKKNSNLLYAHKYNAKTKPLYGKKFGRSQQGVIALINAEGTIHQGTSANKYNGGPSIGSDSLVLAIRSATLDKDVKAIVIRVNSGGGSYIASDMVHHEIEASKKAGKKIVISMGTYCASGGYFFACNADKIVALGATLTGSIGVLTAKFNLKGMWEEKVHVKFDALHLNPDGATDNSTYFSSLHNYTEKQLAEVNSYMDFIYEDFTSKVSKGRRLTRDQVEEIARGRVWTGAQALKLSLVDKLGGLKEAIEVAKELVGIASNVQPHVVTYPKETVLSQLVASSANNSQDLERRGTPAQASITHSVGVSTSIFTKFSTLTKLILLPNNSISSIANTLINNQKNSNILSMNQSSLISSSF
Protein: GH03554p (Splicing factor 3a subunit 1) (Q9VEP9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Splicing factor 3A subunit 3
- Splicing factor 3A subunit 2
- Splicing factor 3B subunit 1
- LD45152p
- Splicing factor 3B subunit 3
- Splicing factor 3B subunit 4
- Splicing factor 3B subunit 5
- Probable ATP-dependent RNA helicase DDX46
- Probable U2 small nuclear ribonucleoprotein A'
- U5 small nuclear ribonucleoprotein 200 kDa helicase
Sequence:
MATLDAEANEEQFGNDQPKSMSGPIIGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNELGNPKFNFLNGGDPYHAYYRHKVNEFREGNDAGITALASMKQLAVTSAAQQRQQELLKQVVEQQFVPKEPPPEFEFIADPPSISALDLDIVKLTAQFVARNGRQFLTNLMSREQRNFQFDFLRPQHSLFQYFTKLLEQYTKVLIPPKDLLGKLRSESAPGRSSMNQVLEQVKYRANWQRHQEAQRRREEEKIERERVAYAQIDWHDFVVVETVDYQPFESGNFPPPTNPDEVGARVLMEERLMDEEGDTEMQIESDDEGDSQANNLLDSGLKLSQMENRVGIQMKNVSSYGQPTGPKRDNTQVQDMDEASSDEDTPTTKLQPSVAPMLPPTHDKVVVKKYDPKATQPKQAPMPTDEYLISPITGEKIPASKVSEHMRIGLLDPRWVEQRDKHTVEKINQDNVFAAGTAIEASLKQLAERRTDIFGVGDEETVIGKKLGEEETKKDDRVTWDGHTSSVEAATRAARANITLEEQIHQIHKVKGLLPDEEKEKIGPKPVGNKATLSAPPQPSTKSQHSHSSQSQHHQGGGGGHHGHHNPHHHHPPHQQAPPHQSHHHHPPQQPQPVMQLMQLRPTMMQPPFGAGGGGYMNMQPGGIPQQIAPAPPVDIMEEEPPSKKIRSEDNLIPEADFIATHKSPVTIQVLVPNSDKSEWKLNGQMIAVTMALSEPIANLKTKLQDETGMPPAKQKIFYEGMFFKDSNTMAFYNLVNGTTVHLQVKERGGRKK
Protein: Polycomb protein PHO (Protein pleiohomeotic) (Transcription factor YY1 homolog) (Q8ST83)
Organism: Drosophila melanogaster (Fruit fly)
Function: Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.
Subcellular location: Nucleus {ECO:0000269|PubMed:16618800}.
Interaction partners:
- Polycomb protein Sfmbt
- Histone-lysine N-methyltransferase E
- Polycomb group protein Pc
- Polycomb protein esc
- Polycomb protein Su
- E3 ubiquitin-protein ligase RING1
- Polycomb group protein Psc
- Chromatin-remodeling ATPase INO80
- Histone deacetylase HDAC1
- Polycomb protein esc
Sequence:
MAYERFGIILQSEQYDEDIGNTKVNQKMNEGNHYDLHRKNAFDRIIHSESKKGDNVINYNIHENDKIKAADNIFSSKLKMNPNMSYEMNINCFKNIGYGENQETSKVLTNSLSNNDINTEESGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIKTMEGEFSVTMWASGISDDEYSGSDQIVGASDLLKGKEEFGIDGFTSQQNKEYQKMESKFTNAQTLEMPHPISSVQIMDHLIKERGNLSQENNISERILSKTTLSFEEPILLPDSSSIELVNETAAMTINNHRTLSNHTGNTGDLHALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRNTSISGKSGCSNAESNSQSEDTSANYVKVELQDSVTENHVPFVVYAD
Protein: Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6) (Q6NXT4)
Organism: Homo sapiens (Human)
Function: Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19366695}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A5
- Proton-coupled zinc antiporter SLC30A1
- Probable proton-coupled zinc antiporter SLC30A4
- Alkaline phosphatase, tissue-nonspecific isozyme
- Zinc transporter SLC39A7
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter ZIP9
- Calcium/manganese antiporter SLC30A10
- Zinc transporter ZIP6
- Zinc transporter ZIP13
Sequence:
MGTIHLFRKPQRSFFGKLLREFRLVAADRRSWKILLFGVINLICTGFLLMWCSSTNSIALTAYTYLTIFDLFSLMTCLISYWVTLRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALCFNLFTMLSIRNKPFAYVSEAASTSWLQEHVADLSRSLCGIIPGLSSIFLPRMNPFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVTNRLYTLVSTLTVQIFKDDWIRPALLSGPVAANVLNFSDHHVIPMPLLKGTDDLNPVTSTPAKPSSPPPEFSFNTPGKNVNPVILLNTQTRPYGFGLNHGHTPYSSMLNQGLGVPGIGATQGLRTGFTNIPSRYGTNNRIGQPRP
Protein: Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression of viral proteins) (P69718)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)
Function: Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs. Rev itself is translated from a fully spliced mRNA that readily exits the nucleus. Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1. KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus. In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs. Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface. Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex. Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export. Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import. The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
Subcellular location: Host nucleus, host nucleolus {ECO:0000255|HAMAP-Rule:MF_04077}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04077}. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm. {ECO:0000255|HAMAP-Rule:MF_04077}.
Interaction partners:
Sequence:
MAGRSGDSDEDLLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE
Protein: At5g44250 (Similarity to unknown protein) (Q9FFG7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MWGIGGNYYWRKKNNNGGESEAIVVVFAWMSSEERNLKNHVDLYSSLLWDSLVCHSQFLNMFLPDKAADLASNVVSELVKELKAKPVPLVFASFSGGPNACMYKVLQILEGTCETGLNPDDCRLVRNCISGFIYDSCPVDFTSDLGARLAVHPTTLKMSSPPKPFVWAANGIASSLDYVFLNRFESQRAEYWQTLYSTIIMRVPYLILCSENDDLAPYQTIHNFATRLQELGGNVKLVKWNDSPHCGHYRYNQVDYKAAVSEFLSKAASVYSQKTRSLDREAMKGTCHDEITEPIQSLGQSTSGLNRSFNGTPLVTTDHFFVPSTVGYYVGRDGGYVQDEHKQDLICLSNTQTNESVKPNGVLGQILFDVYIPKNVEDWDIKLSETGRSRRRPGKRFIRRSRL
Protein: RCC1-like G exchanging factor-like protein (RCC1-like protein) (Williams-Beuren syndrome chromosomal region 16 protein) (Q96I51)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion. Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:28608466, ECO:0000269|PubMed:28746876}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane {ECO:0000269|PubMed:32735630}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion inner membrane {ECO:0000269|PubMed:32735630}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion inner membrane {ECO:0000269|PubMed:32735630}.
Interaction partners:
- Pseudouridylate synthase RPUSD4, mitochondrial
- Pseudouridylate synthase TRUB2, mitochondrial
- Neugrin
- Serine/threonine-protein kinase Nek6
- Nucleoside diphosphate kinase 6
- Mitochondrial mRNA pseudouridine synthase RPUSD3
- FAST kinase domain-containing protein 2
- GTP-binding nuclear protein Ran
- X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
- Guanine nucleotide exchange factor MSS4
Sequence:
MALVALVAGARLGRRLSGPGLGRGHWTAAGRSRSRREAAEAEAEVPVVQYVGERAARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI
Protein: Enhancer of polycomb-like protein (A0A0B4KEK1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361124}.
Interaction partners:
Sequence:
MSKLSFRARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICTGLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQQQRLELTELKFEQMMDRLEKSSGQTVVTLNEAKSLLNQDDETSISVYDYWLNKRLKMQHPLILTVKTESRPGASSNNPYLAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLQRATTILEMVRRREETKRDHLKMTVNIFEKRVEMRDFNGAVYSELNSQYKNTRCVFGHLLLMKKDAISGSGNGNSSRKEKRPYKKRKHKLPRDKQQHQQQQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAANDSIADSEEEDYFGAGAQNGNKLGSESEEETPFAFRRRSSCVYLPTRQRDGRYPWDSADEDMAPSGACSDAKYRYTLTSLNYPRPRCIGFARRRLGRGGRILLDRATTNFDDFWSQLDYTVMESVTVNKCRDKIKQRDPDQLCKPSSPPTVVDLVPAGKPVDGEHPVPELIKEEPSSDTEKPVAATESGRESKERELEEKFENDVDDEFVASDDENVSRLGIYSSAVTLPQSCADLRQKRRRLRRKKQQLRELNAAKRLKRSSEAVATAEDVQLEDEDTKPDLRPLPRAYLQRLALILGQKLKVEEDDNTEVSENVAPELLEMNDPEQLQPPRANHQQHHRSNHNNNNNTVLNNNNSSSSNVMNKDVSISEKINVIKQEAEELVGGKCEDQPVASTSAAAAAARAAEAAAAAEAASSTTTLAAPNPGPSLEEVAKTIKREMIDADDSNEPLSSIRTAAVMLSTQTSVSELMDDEAEDDVNLAQLSSIIRHTAVKKELEAQQHQQQVQHEQMQAARKMEEDEAAPCLNQLPDVIRLRNIRNSQVHARPKDLFVQAPVDEEFNADYMGGLSPTSSQRLDICNELLSEIRRDWLHFRPKTPTDELSDSQDCEVGKTCDSHAVDWTQDTPISVELNRLGKREAEESDSSSYFLSSGFKYRDLESDAQLLQTVQAQDYARGSSKSPNCSGSGSGSALEFNLSGGDSLNDINNLLGCDDEDDNHEHMLDNILQECAMDDPKALNQATNFWNGILDGEAAVDEVEMADQLLDCIDEKKSKVGAADTSKRAGRNRKARLIQAPVGSSAFTVCPTAETLKERELFFSQAPPVEVPPKEKTPAEVELPEVVVKETANLPVKVEAVEKPQSEVLPVAPQPQQLQPQAITLPTTQLINIPAQISTQKQHQQPQVTQLLNQFANAGPQIIARTEYGGGAAVGDIVTITPHTGSSPLPTLTAQQQLQHQLAQAQLRNVTVQQRQATPQNPNQNQNPQQQLLFQMQRDPSRSLTPLQAAGAGATGNHLIYTTSCGEIVTAGAAASASQKVTYAIQKAGVSSGGATTASIGPNTVITLSNVKVQNDDISSGGSGNSGSSVNIINTASGQQLAVHSIAGMQQQGQQQVQQVTTSTPLLVATPTRNNVQQQQQQLVQQQPIVWRQVSGTNTAVATTAVLSTTVDSSPKAVTNQILWTSRATQKRQLNGPENTDINKLLLNRKLPRKQQIQQQHQQIQLTKQQLQQLVQHEELDDLVATSTGNSGDQMETGDGLQQQQQQQQQQQQLQKLSKVIKMSQFPLLVSDVSLQQQQSVSGQAQQQQLKPNSAAAIAANHNYSLHPASTAIITAQATPQQANKIFLTSSNSGGGGSAGNFTIATASELQAAAAGQKLHYKELPNSNLKLNFVSSAGTGEQTQQVGATTVLLNKSQQQQQQQQHQKLKTLATTGNSQTGQGDKRVLYTSLLNVKPLQKNNSGQMQMQLGPGGLQQVLRGRLNNSAIITRTLPLGTTVNSTGGAVGPTTTTIRQLVTTNANNVSSQDGNLLSAKEVGKALTVEQVIASANNGGVVLPTSNNNNNNNGSGAGGNGGPLNSGVNATGAGGGGSTGAGVGGAGVTSTINR
Protein: Protein NDNF (Epidermacan) (Neuron-derived neurotrophic factor) (Q8C119)
Organism: Mus musculus (Mouse)
Function: Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus. Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling (By similarity). Also regulates extracellular matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms.
Subcellular location: Secreted {ECO:0000269|PubMed:18757743}.
Interaction partners:
Sequence:
MELFYWCLLCLLLPLTSRTQKLPTRDEELFQMQIRDKEFFHDSSVIPDGAEVSSYLFRDTPRRYFFMVEEDNTPLSVTVTPCDAPLEWKLSLQELHEGSSADGSGDPELLDQQKQQMTDVEGTELFSYKGNDVEYFLSSSSPSGLYQLELLSTEKDTHFKVYATTTPESDQPYPELPYDPRVDVTSFGRTTVTLAWKPSPTASILKQPIEYCVVINKEHNFKSLCAAETKMNADDAFMVAPKPGLDFNPFDFAHFGFPTDNLGKDRSLLAKPSPKVGRHVYWRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFMVNTNTNMSTAYVGAFVRTKEEAKQKTVELKDGRVTDVFVKRKGKKFLRFAPVSSHQKVTFFIHSCMDAVQVQVRRDGRLLLSQNVEGIRQFQLRGKPKGKYLIRLKGNRKGASKLKILATTRPSKHAFPSLPEDTRIKAFDKLRTCSSVTVAWLGTQERRKFCIYRKEVDGNYSEDQKRREQNQCLGPDTRKKSEKVLCKYFHSQNLQKAVTTETIRDLQPGKSYLLDVYVVGHGGHSVKYQSKIVKTRKVC
Protein: A-kinase anchor protein 4 (AKAP-4) (A-kinase anchor protein 82 kDa) (AKAP 82) (mAKAP82) (p82) (Major sperm fibrous sheath protein) (Protein kinase A-anchoring protein 4) (PRKA4) (Q60662)
Organism: Mus musculus (Mouse)
Function: Major structural component of sperm fibrous sheath. Plays a role in sperm motility.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q5JQC9}. Note=Localizes to the principle piece of the sperm flagellum. {ECO:0000250|UniProtKB:Q5JQC9}.
Interaction partners:
- Fibrous sheath-interacting protein 2
- Calcium-binding tyrosine phosphorylation-regulated protein
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Outer dense fiber protein 1
- Ropporin-1
- Spermatid nuclear transition protein 1
- Probable ATP-dependent RNA helicase DDX17
Sequence:
MIAYCGTTTMSDDIDWLHSRRGVCKVDLYSPKGQQDQDRKVICFVDVSTLNVEDKDSKGAAGSRSEGELNLETLEEKEIIVIKDTEKQDQSKTEGSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSASSCKHKVGDLEGDYSKIPSENCYSVYADQVNFDYLNKGPQNLRLEMAASKNTNNNQSPSNPATKSPSNQRSVATPEGECSMDDLSFYVNRLSSLVIQMARKEIKDKLEGGSKCLHHSMYTSGDKGKTSPRSAVSKIASEMAHEAVELTSSEMRGNGEDCRDGRKTFLYSEMCNKNKCGEKQQMCPKDSKEFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIPACVVLKRVLLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRLVSALLGEKKETKSQSLAYATLKAGTNDPKCKNQSLEFSAMKAEMKGKDKCKSKADPCCKSLTSAERVSEHILKESLTMWNNQKQGNQGKVTNKVCCTSKDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPCEEECPGSSMGYMSQSAQYEKCGGGQSSKSLSMKHFETRGAPGPSTCMKENQLESQKMDMSNMVLSLIQKLLSESPFSCDELTESDNKRCCDPRSSKAAPMAKRPEEQCQDNAELDFISGMKQMNRQFIDQLVESVMKLCLIMAKYSNNGAALAELEEQAALVGSGSRCGRDAMMSQNYSETPGPEVIVNNQCSTTNLQKQLQAVLQWIAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYSVGDLLQEVMKFAKERQLDEAVGNMARKQLLDWLLANL