wanglab/gogpt-training-data huggingface dataset:
Protein: Ly-6/neurotoxin-like protein 1 (GC26) (P0DP60)
Organism: Mus musculus (Mouse)
Function: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR. In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life.
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:10402197}. Endoplasmic reticulum {ECO:0000269|PubMed:25193667}. Note=Detected in Purkinje cells soma and proximal dendrites. {ECO:0000269|PubMed:10402197}.
Interaction partners:
- Lymphocyte antigen 6H
- Secreted Ly-6/uPAR-related protein 1
- Neuronal acetylcholine receptor subunit alpha-7
- Ly6/PLAUR domain-containing protein 6
- Ly6/PLAUR domain-containing protein 2
- Lymphocyte antigen 6K
- Ly6/PLAUR domain-containing protein 1
- Neuronal acetylcholine receptor subunit alpha-4
Sequence:
MTHLLTVFLVALMGLPVAQALECHVCAYNGDNCFKPMRCPAMATYCMTTRTYFTPYRMKVRKSCVPSCFETVYDGYSKHASATSCCQYYLCNGAGFATPVTLALVPALLATFWSLL
Protein: Gastrin-releasing peptide (GRP) [Cleaved into: Neuromedin-C (GRP-10) (GRP18-27)] (P63153)
Organism: Sus scrofa (Pig)
Function: Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P07492}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q863C3}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8R1I2}. Note=In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. {ECO:0000250|UniProtKB:Q8R1I2}.
Interaction partners:
- Gastrin releasing peptide receptor
- Neuromedin-B
- Bombesin receptor subtype 3
- Neuromedin-B receptor
- Pro-glucagon
- Neurotensin/neuromedin N
- Gastrin
- Cholecystokinin
- Signal peptidase complex subunit 2
- Signal peptidase complex subunit 1
Sequence:
MRGREFPLVLLALVLCQAPRGPAAPVSVGGGTVLAKMYPRGNHWAVGHLMGKKSTGESPYAYEGGNMKEQLREYIRWEDATRNLLSLLEAKGIGSHQPPQWEPLGIRQSTWDSKDGSNFKDMGPRLKVDGLSAPGSQHEGRIPQLN
Protein: Beta-conglycinin alpha subunit 2 (CG-alpha-2) (Beta-conglycinin alpha-related subunit) (allergen Gly m 5) (P0DO15)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Seed storage protein. Accumulates during seed development and is hydrolyzed after germination to provide a carbon and nitrogen source for the developing seedling.
Subcellular location: Vacuole, aleurone grain {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:15447650}. Protein storage vacuole. Note=Localizes in protein storage vacuoles in cotyledons of developing and mature beans (PubMed:15447650). Synthesized and assembled into trimers in the endoplasmic reticulum, and transported to the protein storage vacuoles by the dense vesicles (PubMed:15447650). {ECO:0000269|PubMed:15447650}.
Interaction partners:
- Glycinin G2
- Basic 7S globulin 2
- Glycinin G1
- Flavonol-3-O-glucoside/galactoside
- Inactive UDP-glycosyltransferase 79A6 rhamnosyltransferase)
- UDP-glycosyltransferase 79A6
- Protein EARLY FLOWERING 4 domain-containing protein
Sequence:
MMRARFPLLLLGLVFLASVSVSFGIAYWEKENPKHNKCLQSCNSERDSYRNQACHARCNLLKVEKEECEEGEIPRPRPRPQHPEREPQQPGEKEEDEDEQPRPIPFPRPQPRQEEEHEQREEQEWPRKEEKRGEKGSEEEDEDEDEEQDERQFPFPRPPHQKEERKQEEDEDEEQQRESEESEDSELRRHKNKNPFLFGSNRFETLFKNQYGRIRVLQRFNQRSPQLQNLRDYRILEFNSKPNTLLLPNHADADYLIVILNGTAILSLVNNDDRDSYRLQSGDALRVPSGTTYYVVNPDNNENLRLITLAIPVNKPGRFESFFLSSTEAQQSYLQGFSRNILEASYDTKFEEINKVLFSREEGQQQGEQRLQESVIVEISKEQIRALSKRAKSSSRKTISSEDKPFNLRSRDPIYSNKLGKFFEITPEKNPQLRDLDIFLSIVDMNEGALLLPHFNSKAIVILVINEGDANIELVGLKEQQQEQQQEEQPLEVRKYRAELSEQDIFVIPAGYPVVVNATSNLNFFAIGINAENNQRNFLAGSQDNVISQIPSQVQELAFPGSAQAVEKLLKNQRESYFVDAQPKKKEEGNKGRKGPLSSILRAFY
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (A0A8I6AJ90)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPVPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPTAAPISTSELKKVVALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGEPQGVIRHYVVCSTPQSQYYLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKIPYERFTNSETAEHIAQGLRLYRPHLASDRVYTIMYSCWHEKADERPSFKILLSNILDVMDEES
Protein: Protein tyrosine phosphatase receptor type K (E9PRW2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIICTFLVYVLMSSVLTICVIHRCKYASHGNERLPSCLPHPHYWGSVIHRYTYASHGNERLPLFLPHPVDEEVFGDIGTKPSN
Protein: RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE) (Q9Y224)
Organism: Homo sapiens (Human)
Function: RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport.
Subcellular location: Nucleus {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Cytoplasm, cytosol {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15147888}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15147888}. Note=May localize at the centrosome during mitosis (PubMed:15147888). Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26864902}. Cytoplasm {ECO:0000269|PubMed:26864902}. Note=(Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (PubMed:21900157, PubMed:26864902). {ECO:0000269|PubMed:21900157, ECO:0000269|PubMed:26864902}.
Interaction partners:
- RNA-splicing ligase RtcB homolog
- ATP-dependent RNA helicase DDX1
- Protein FAM98B
- Ashwin
- Protein FAM98A
- Protein archease
- Ninein
- TATA-binding protein-associated factor 2N
- Protein FAM98C
- Regulator of microtubule dynamics protein 3
Sequence:
MFRRKLTALDYHNPAGFNCKDETEFRNFIVWLEDQKIRHYKIEDRGNLRNIHSSDWPKFFEKYLRDVNCPFKIQDRQEAIDWLLGLAVRLEYGDNAEKYKDLVPDNSKTADNATKNAEPLINLDVNNPDFKAGVMALANLLQIQRHDDYLVMLKAIRILVQERLTQDAVAKANQTKEGLPVALDKHILGFDTGDAVLNEAAQILRLLHIEELRELQTKINEAIVAVQAIIADPKTDHRLGKVGR
Protein: Tapetum-specific protein A9 (Q00762)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Cytochrome P450 703A2
- Flowering-promoting factor 1-like protein 1
- Flowering-promoting factor 1-like protein 2
- Probable magnesium transporter NIPA1
- BZIP family transcription factor
- Nudix hydrolase 2
- Probably inactive leucine-rich repeat receptor-like protein kinase At5g06940
- Probable leucine-rich repeat receptor-like protein kinase At2g33170
- LRR receptor-like serine/threonine-protein kinase RGI1
- Cytochrome P450 704B1
Sequence:
MVSLKSLAAILVAMFLATGPTVLAQQCRDELSNVQVCAPLLLPGAVNPAANSNCCAALQATNKDCLCNALRAATTLTSLCNLPSFDCGISA
Protein: Glutathione reductase (EC 1.8.1.7) (C8VUN9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU365016}.
Interaction partners:
- Glutathione peroxidase
- 2-oxoglutarate dehydrogenase, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit alpha
- Mitochondrial peroxiredoxin
- Thioredoxin reductase
- 3-methyl-2-oxobutanoate dehydrogenase
- Pyruvate dehydrogenase E1 component subunit beta
- Flavoprotein, putative
- Gamma-glutamyltranspeptidase
- Glutathione hydrolase
Sequence:
MLSRSSLRSLSAQASKIRLTRSSLVCSPITQSNRAYTSYGIATRNQKRGVLDSSSRSAISTPTGLRLASLTRQFSSTSPAANSSNMPPVETKQYDYIVLGGGSGGSGSGRRAAGWYGAKTLIVESGRAGGTCVNVGCVPKKMTWNFASITESIEAGRHYGYDLPHNIDVNYTHFKKLRDSTIERLNGVYEKNWGNEGIDLVHGRARFVEKKTIEVTNQDGSRTRYTAPHILIATGGRPSLPDIKGSEHGISSDGFFEIEELPPKLAVVGAGYIAVELAGVMGTVGVDTHMFIRGETFLRKFDPMIQKTMTERYEAVGIHVHKKHPGIKEVQLLRDGKGKDKLLKLIMNDGSEMEVNELLWAIGRVPEVEDLHLEIPGVELNKSGHVVVDEYQNTNVEGIYAIGDVTGQAELTPVAIAAGRQLGNRLFGGPQFKNAKLSYDNIPTVVFSHPEVGTVGLTEPQARERFGDENVKVYHTRFPAMFYSVFPPEEKAKNPTEFKMVVAGPEEKVVGLHLLGLGVGEMTQGFGVAVKMGATKKDFDSCVAIHPTSAEELVTLR
Protein: Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 1 (AthCYSTM1) (O23035)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in aluminium (Al) tolerance. Involved in resistance to abiotic stress.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29272523}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:29272523}.
Interaction partners:
- CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
- Protein S40-4
- Marker for oxidative stress response protein
- Disease resistance protein RPP1-WsB, putative domain family protein)
- Defensin-like protein 195
- Tripeptidyl-peptidase 2
Sequence:
MSQYDHNQSAGANPPPPMSTCTSPPPPIGYPTNQPSHGSVAQGKVETKSKGDGFFKGCLAAMCCCCALDICF
Protein: Caspase 2, apoptosis-related cysteine peptidase (Caspase 2, apoptosis-related cysteine protease) (Caspase-2 (EC 3.4.22.55)) (Q0PKX3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MLGECGMTKWERLALRRNSVKMLQDLVVDDLLIQCLQQDGILTDSMAESIMAKPTSQGRSHQLLFLLPKRGPRAFSTFCSALKETEQHHLCKLLMDFTEKDKCFSEPSLSLPTQECVTPAKRPRTHESMEMCLDADSPVTTAVLPCTPEFYQSHRPQAYPMRSCPRGLALVLSNVRFDSANTDLDIRRGGEVDEETLRRLFTELDFKVSLHRDLTAEAMRRCLEQFAQQQEHAAYDCAVVCLLSHGVEGSVYGTDGQLLELDWVFEVFDNARCPLLQNKPKMFFIQACRGEEMDNGVDQLDGQERTQSPGCEQRDAGREGERDNREKKEEKERERLRVKLPQRSDMICGFATLKGTAAMRNTKKGSWFIQELNTAIRQRANNTHLSDILVQVNGQIKSREGYAPGSAHHRCKEMSEFTSSLCKDLYLFPKYYPSN
Protein: Multidrug resistance-associated protein 1 (EC 7.6.2.2) (EC 7.6.2.3) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (Leukotriene C(4) transporter) (I3L4X2)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
XAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGSTVMDEEEAGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Protein: Probable serine/threonine protein kinase IREH1 (EC 2.7.11.1) (Protein IRE homolog 1) (AtIREH1) (F4J6F6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in root hair elongation.
Interaction partners:
- GTP-binding protein BRASSINAZOLE INSENSITIVE PALE GREEN 2, chloroplastic
- GATA transcription factor 7
- At1g69210/F4N2_11
- Protein ARABIDILLO 1
- Protein MEI2-like 4
- Aspartate aminotransferase, mitochondrial
Sequence:
MVFKNKLFFSSKKSGSSSPDSSNSPRSVGSNSPIRSDKKKSKSASKDEPPIPIPGFVGVGCKQTQIKDGLKKKDGSSKGKQLSSEVQAHSIGKSNLSPSSEVKKPPPPEVKEGPAFVSPIMASSLGLNRIKTRSGPLPQERVFNYRNDPATSNLSKMGADGGDLGSGSATSGSGSGNRKKEAGSSKLGLEENMDRTRPSDNKSDRDSLSPDTGPPRSLSPTLPPSGSRLQNVASSSGTGRSEMSSGRSGPLRNSDFCTPENSYEWENPKESESPRYQALLRMTSAPRKRFPGDIKSFSHELNSKGVRPFPLWKPRRSNNVEEVLNLIRAKFEKAKEEVNSDLAVFAADLVGVLEKNAESHPEWEETFEDLLILARSCAMTTPGDFWLQCEGIVQDLDDRRQELPPGVLKQLHTRMLFILTRCTRLLQFHKESWGEEEQVVQLRQSRVLHSIEKIPPSGAGRSYSAAKVPSTKKAYSQEQHGLDWKEDAVVRSVPPLAPPENYAIKESESPANIDRMSSWKKLPSPALKTVKEAPASEEQNDSKVEPPNIVGSRQGRDDAAVAILNFPPAKDSHEHSSKHRHNISWGYWGEQPLISEESSIMCRICEEEVPTTHVEDHSRVCTLADKYDQKGLSVDERLMAVAGTLDKIAETFRHKDSLAAAESPDGMKVSNSHLTEESDVLSPRLSDWSRKGSEDMLDCFPEADNSIFMDDLRGLPLMSCRTRFGPKSDQGMTTSSASSMTPRSPIPTPRPDPIEQILGGKGTFHDQDDIPQMSELADIAKCAADAIPGDDQSIPFLLSCLEDLRVVIDRRKFDALTVETFGTRIEKLIREKYVHMCELMDDEKVDLLSTVIDEDAPLEDDVVRSLRTSPVHPRDRTSIDDFEIIKPISRGAFGRVFLAKKRTTGDLFAIKVLKKADMIRKNAVESILAERDILINVRNPFVVRFFYSFTCRDNLYLVMEYLNGGDLYSLLRNLGCLEEDIVRVYIAEVVLALEYLHSEGVVHRDLKPDNLLIAHDGHIKLTDFGLSKVGLINSTDDLAGPAVSGTSLLDEEESRLAASEEQLERRKKRSAVGTPDYLAPEILLGTGHGATADWWSVGIILFELIVGIPPFNAEHPQQIFDNILNRKIPWPHVPEEMSAEAHDIIDRFLTEDPHQRLGARGAAEVKQHIFFKDINWDTLARQKAAFVPASESAIDTSYFRSRYSWNTSDEQFFPSGEVPDYSDADSMTNSSGCSSNHHEEGEAEECEGHAEFESGIPVDYSFSNFSFKNLSQLASINYDLLSKGWKDEPQQIPHHK
Protein: S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2) (Q9H2M3)
Organism: Homo sapiens (Human)
Function: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.
Interaction partners:
- S-adenosylmethionine synthase isoform type-1
- Adenosylhomocysteinase
- Cystathionine gamma-lyase
- Adenosylhomocysteinase 3
- S-adenosylmethionine synthase isoform type-2
- Cystathionine beta-synthase-like protein
- S-adenosylhomocysteine hydrolase-like protein 1
- Betaine--homocysteine S-methyltransferase 1
- Methylenetetrahydrofolate reductase
- Methionine adenosyltransferase 2 subunit beta
Sequence:
MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLHMEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYKYQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGPEGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPLGFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSKPDF
Protein: ESAT-6-like protein EsxK (P9WNJ7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Secreted {ECO:0000269|PubMed:12919853}. Note=Probably secreted via the ESX-5 / type VII secretion system (T7SS). {ECO:0000305|PubMed:19876390}.
Interaction partners:
- ESAT-6-like protein EsxL
- ESAT-6-like protein EsxO
- PPE family protein PPE18
- ESAT-6-like protein EsxN
- ESAT-6-like protein EsxI
- 6 kDa early secretory antigenic target
- ESAT-6-like protein EsxB
- ESAT-6-like protein EsxP
- ESAT-6-like protein EsxJ
- ESAT-6-like protein EsxW
Sequence:
MASRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGWSGMAEATSLDTMAQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS
Protein: Pathogenesis-related protein 5-like (Q19874)
Organism: Caenorhabditis elegans
Interaction partners:
- Pathogenesis-related protein 5-like
- GH18 domain-containing protein
- C-type lectin domain-containing protein
- Putative cytochrome P450 CYP13A4
- ShKT domain-containing protein
Sequence:
MALIKLTLAVLLLALGAEARKITIYNKCPFTIWPGILGPGNPSGGGFKLNAGQSRDINVDDAWTAGRVWARTGCDGNFNCETGFCRNSEQCNGAGGVPPASLAEFTLKAWGGQDFYDVSLVDGYNLPVLIDPHGGSGCKRAGGCVKDINAECPAALSVKGHNGKTVACKSGCLGYNTDQECCRGAYGTPDKCHRSATAQMFKDACPTAYSYAYDDGSSTFTCQPSASYTVQFC
Protein: fMet-Leu-Phe receptor (N-formyl peptide receptor) (N-formylpeptide chemoattractant receptor) (D4A7Q2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Annexin A1
- Formyl peptide receptor 2
- Guanine nucleotide-binding protein G
- Neuroendocrine secretory protein 55
- Formyl peptide receptor 3
- Guanine nucleotide-binding protein G
Sequence:
MNTNMSAVNFMNMSGSTRSVSAGYIVLDIFSYLIFALTFVLGVLGNGLVIWVAGFRMKRTVTTISYLNLAIADFCFTSTLPFYIVSLVMGGIWPFGWFMCKFIYTVIDINLFGSVFLIALIALDRCVCVLHPVWAQNHRTVTLAKKVIIVPWICAFLLTLPVIIRVTTVPNRLGPGKTACALDFSPWTKDRAEKDKVAITMYTVRGIIRFILGFSTPMSIVAICYGLIATKIHRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVGLIRTIQIREHLRNIPQSTLTAMKITSSLAFFNSCLNPILYVFMGQDFRQRLIHSLPASLERALSEDSAQTSDTGTNLGANSIPENPANAM
Protein: Long chain fatty acid elongase 1 (ELO-1) (EC 2.3.1.-) (Elongation of long chain fatty acids protein 1) (Long-chain 3-oxoacyl-CoA synthase 1) (CEELO1) (G5EEE5)
Organism: Caenorhabditis elegans
Function: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids. Condensing enzyme that catalyzes the elongation of monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Very-long-chain 3-oxooacyl-coA reductase let-767
- Delta
- Omega-3 fatty acid desaturase fat-1
- Delta
- Delta
- Delta
- Delta
- Delta
Sequence:
MAQHPLVQRLLDVKFDTKRFVAIATHGPKNFPDAEGRKFFADHFDVTIQASILYMVVVFGTKWFMRNRQPFQLTIPLNIWNFILAAFSIAGAVKMTPEFFGTIANKGIVASYCKVFDFTKGENGYWVWLFMASKLFELVDTIFLVLRKRPLMFLHWYHHILTMIYAWYSHPLTPGFNRYGIYLNFVVHAFMYSYYFLRSMKIRVPGFIAQAITSLQIVQFIISCAVLAHLGYLMHFTNANCDFEPSVFKLAVFMDTTYLALFVNFFLQSYVLRGGKDKYKAVPKKKNN
Protein: Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (Q6GPH6)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000269|PubMed:38614099}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MNVDAEASMAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEMRLLEMEFEERKRAAEQRQKAENFWTGDTSSDQLVLGKKDMGWPFQADGQEGPLGWMLGNLWNTGLFCLFLVFELLRQNMQHEPAFDSSSEEEEEEVRVVPVTSYNWLTDFPSQEALDSFYKHYVQNAIRDLPCTCEFVESFVDDLIEACRVLSRQEAHPQLEDCLGIGAAFEKWGTLHETQKFDILVPIVPPQGTMFVLEMRDPALGRRCGCVLVESECVCKREKLLGDVLCLVHHHRDPSAVLGKCSSSIKAALCTGFHLDVCKTVQWFRNMMGNAWALVAHKYDFKLSLPPSTTSCKLRLDYRSGRFLSIHLVLGVQREDTLVYLVSQAPDQEQLTSVDWPESFVACEHLFLKLVGRFAPENTCHLKCLQIILSLRQHQSLPHGASRPILTSYHFKTALMHLLLRLPLTDWAHNMLSQRLQDILWFLGRGLQQRSLHHFLIGNNFLPLTIPIPKTFRNAEPVNLFQHLVLNPKAHSQAVEEFQNLLTQVKTLPHAPLAAAP
Protein: Cilia- and flagella-associated protein 298 (Protein kurly) (Q6DRC3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26904945}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A0A1L8HCK2}. Note=Appears in cytoplasmic puncta, compatible with a centrosomal localization. {ECO:0000269|PubMed:26904945}.
Interaction partners:
- Dynein axonemal assembly factor 1
- TOG domain-containing protein.
- Dynein axonemal assembly factor 4.
- Cilia- and flagella-associated protein 300
- Sperm-associated antigen 1A
- Dynein axonemal assembly factor 11
- Dynein axonemal assembly factor 3
- Zinc finger MYND domain-containing protein 10
- PIH1 domain containing 3
- Dynein axonemal assembly factor 10
Sequence:
MVQLHVKRGDESQFLFNTTVDVQIETLTQQICEIYNARLKVDRICTEIPELADHGISLPPNMQGLTDDQIVELKLKDEWEERCIPSGGAEFKKDEIGRRNGHAPNEKMKDVLRRTMEEAKALISKKQLQANVCVTMEMVKEALDQLRGAVMIVYPMGLPPHDPIRMEIENQEDLTGTQASLQVITNEEAQLWWASKELHRGKKLQDYIGKNEKTKIIVKIQKRGQGAPAREPVVSEDEQKQMMLHYYKRQEELKKLEEADDDTHLQSEWSDRQALKRQFQGLTNIKWGPR
Protein: Protein HRI1 (HRR25-interacting protein 1) (Q05905)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Unknown. Non essential.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Translocation protein SEC72
Sequence:
MPALLKRLLFQVGPHPNERTFTLSSVSTDGHYISLRPFVKPSGDELSFPFEWAFAGTNETVKANDQGNGVVTQDFNFWLDTNVYLNVPNTHRGEVNTTWKNWDSGCVEETGAVYPFGADKESVSFRELWQPVDPSREDLVIVSPNNEKFSSNARSIVLKVTDEAYDGLVIVIGRWIQGFLSQKNNNTIEGLNFIRLLEKDSGKSEFLLSYGKEVNKIPQSYENLKKGSTVTSNGLNWEVIEYHA
Protein: Sm-D1 (Q9GYZ5)
Organism: Trypanosoma brucei
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPAAESSTLIGFLQQLRGTQVEIEMMNSTIVTGEITFVEANMNTYMRHVKITAKGKNPEMAETYMVCGSKIRYVILPEAMNTDDVLVKAAAAKARPGSKRTERSNE