Protein: Serine/threonine-protein kinase Tao (EC 2.7.11.1) (Q0KHQ5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Serine/threonine-protein kinase which regulates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein. In imaginal cells, phosphorylates and activates hpo and leads to repression of yki. In the midgut, negatively regulates the proliferation of intestinal stem cells through the Hippo/SWH pathway. Independent of the hippo/SWH pathway, regulates epithelial morphogenesis in follicle cells by promoting the endocytosis of Fas2 and reducing lateral adhesion between epithelial cells which, in turn, permits shrinking of the lateral membrane and initiates morphogenesis of the squamous epithelium. Required for the development of both the mushroom body and the ellipsoid body in the brain and may act as a negative regulator of the par-1 kinase. Negatively regulates the JNK pathway which increases sensitivity to ethanol exposure. Plays a role in the control of cell shape by negatively regulating the growth of microtubule plus-ends as they contact the actin-rich cell cortex. Required for the induction of apoptosis in pole cells by promoting expression of skl which enhances activity of the apoptosis activator hid.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20647372}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20647372}. Cytoplasm {ECO:0000269|PubMed:23266957, ECO:0000269|PubMed:26954546}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:23266957, ECO:0000269|PubMed:26954546}. Note=Localizes to a subset of microtubules in interphase and mitotic cells (PubMed:20647372). In follicle cells, accumulates in the basolateral cytoplasm and at the lateral membrane (PubMed:23266957). {ECO:0000269|PubMed:20647372, ECO:0000269|PubMed:23266957}.; SUBCELLULAR LOCATION: [Isoform D]: Cytoplasm {ECO:0000269|PubMed:25589578}. Perikaryon {ECO:0000269|PubMed:25589578}. Note=In non-neuronal cells, distributed throughout the cytoplasm and enriched at the leading edge of lamellipodia-like structures. In neurons, detected in the perikaryon. {ECO:0000269|PubMed:25589578}.; SUBCELLULAR LOCATION: [Isoform A]: Cytoplasm, cell cortex {ECO:0000269|PubMed:25589578}. Cell projection, axon {ECO:0000269|PubMed:25589578}. Note=In non-neuronal cells, located predominantly at the cell periphery in the cortex. In neurons, enriched in the cell periphery including the axon. {ECO:0000269|PubMed:25589578}.
Interaction partners:
- Schwannomin-interacting protein 1 homolog
- Transcriptional coactivator yorkie
- Probable tRNA
- LD40758p
- Serine/threonine-protein kinase hippo
Sequence:
MPSARPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETESAVGDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHHIAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVTPTNSASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRIQPVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQEEMHEQMSGYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRAKQTSAAEKKLHKEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKDNLKQHEAQEEQRMLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQAHAMLLKHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKTQTKQYKRYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQERAERLRMKHEKHTKELEAFDNESIALGFSTLSLIEVSREAYADEEGSLSGSMISLAHSNSSTSFPAGSL