wanglab/gogpt-training-data huggingface dataset:
Protein: Hsp70-Hsp90 organizing protein 2 (AtHop2) (Q5XEP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the association of the molecular chaperones HSP70 and HSP90. Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Co-chaperone protein p23-1
- Heat shock protein 90-2
- Heat shock 70 kDa protein 4
- Heat shock 70 kDa protein 14
- Heat shock protein 90-1
- Heat shock protein 90-3
- Heat shock protein 90-6, mitochondrial
- Protein ENHANCER OF LHP1 1
- Co-chaperone protein p23-2
- GrpE protein homolog
Sequence:
MADEAKAKGNAAFSSGDFNSAVNHFTDAINLTPTNHVLFSNRSAAHASLNHYDEALSDAKKTVELKPDWGKGYSRLGAAHLGLNQFDEAVEAYSKGLEIDPSNEGLKSGLADAKASASRSRASAPNPFGDAFQGPEMWSKLTADPSTRGLLKQPDFVNMMKEIQRNPSNLNLYLQDQRVMQALGVLLNIQIRTQQAGDDMEIGEEEMAVPSRKEPEVEKKRKPEPEPEPEPEFGEEKQKKLKAQKEKELGNAAYKKKDFETAIQHYSTAMEIDDEDISYITNRAAVHLEMGKYDECIKDCDKAVERGRELRSDYKMVAKALTRKGTALGKMAKVSKDYEPVIQTYQKALTEHRNPETLKRLNEAERAKKELEQQEYYDPNIGDEEREKGNDFFKEQKYPDAVRHYTEAIKRNPKDPRAYSNRAACYTKLGAMPEGLKDAEKCIELDPTFLKGYSRKGAVQFFMKEYDNAMETYQKGLEHDPNNQELLDGVKRCVQQINKANRGDLTPEELKERQAKGMQDPEIQNILTDPVMRQVLSDLQENPAAAQKHMQNPMIMNKIQKLISSGIVQMK
Protein: Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322) (P57087)
Organism: Homo sapiens (Human)
Function: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10779521, ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:31851307}; Single-pass type I membrane protein {ECO:0000269|PubMed:10779521, ECO:0000269|PubMed:11590146}. Cell junction {ECO:0000269|PubMed:10779521, ECO:0000269|PubMed:10945976}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9JI59}. Note=Localized at tight junctions of both epithelial and endothelial cells (By similarity). Specifically localized within the somatodendritic compartment of neurons and excluded from the axon (By similarity). {ECO:0000250|UniProtKB:Q9JI59}.
Interaction partners:
- Tight junction protein 1
- Junctional adhesion molecule C
- Junctional adhesion molecule A
- Immunoglobulin superfamily member 5
- Integrin alpha-4
- Partitioning defective 3 homolog
- Integrin beta-1
- Integrin beta-2
- Golgi reassembly-stacking protein 2
- Occludin
Sequence:
MARRSRHRLLLLLLRYLVVALGYHKAYGFSAPKDQQVVTAVEYQEAILACKTPKKTVSSRLEWKKLGRSVSFVYYQQTLQGDFKNRAEMIDFNIRIKNVTRSDAGKYRCEVSAPSEQGQNLEEDTVTLEVLVAPAVPSCEVPSSALSGTVVELRCQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKLDTGEYSCEARNSVGYRRCPGKRMQVDDLNISGIIAAVVVVALVISVCGLGVCYAQRKGYFSKETSFQKSNSSSKATTMSENDFKHTKSFII
Protein: Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (PAM COOH-terminal interactor protein 2) (P-CIP2) (U2AF homology motif kinase 1) (Q63285)
Organism: Rattus norvegicus (Rat)
Function: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9287318}. Nucleus {ECO:0000269|PubMed:9287318}.
Interaction partners:
- Cyclin-dependent kinase inhibitor 1B
- Stathmin
Sequence:
MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLVYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL
Protein: Histone acetyltransferase HPA2 (EC 2.3.1.48) (Q06592)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: N-acetyltransferase that acetylates histone H3 at 'Lys-14' and histone H4 at 'Lys-5' and 'Lys-12'. Also acetylates polyamines like putrescine, spermidine and spermine, and certain other small basic proteins like nuclear HMG proteins.
Interaction partners:
- D-amino-acid N-acetyltransferase HPA3
Sequence:
MSNTSEDNITVRFVTENDKEGWQRLWKSYQDFYEVSFPDDLDDFNFGRFLDPNIKMWAAVAVESSSEKIIGMINFFNHMTTWDFKDKIYINDLYVDENSRVKGAGGKLIQFVYDEADKLGTPSVYWCTDESNHRAQLLYVKVGYKAPKILYKRKGY
Protein: Eukaryotic translation initiation factor 4E-binding protein Mextli homolog (Q9XW13)
Organism: Caenorhabditis elegans
Function: Plays a role in promoting translation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9VR35}.
Interaction partners:
- Eukaryotic translation initiation factor 4E-3
- K Homology domain-containing protein
- K Homology domain-containing protein
- F-box domain-containing protein
- KH domain-containing protein
- RING-type domain-containing protein
- K Homology domain-containing protein
- K Homology domain-containing protein
- Innexin
- Palmitoyltransferase
Sequence:
MLHNYDDFGGGKMQGAPQVPRNTLLSVDQQLQLMNTINNMVRASQFTSQLANTIFTLCAQLKTSGSMLEQSHKNELNKVFTSLRQACCRDNGQLGTPCRLKIMELVELRAMNWRTNLAHSQYYVNRPEGQHDPAPTVGIPPSATSPPTQVTSSVTSPVPSSPQPPMQFVPQNPMMFQDPMAANHNAGGIFFIPAASTWMNPLMPMPPNPFLPHSMIPPDHQMFLRQRSLNKKPNNLMNKTLQLRHEMIIRNSDSGKIMGVKGRRVAAVEQLTNTVISFQKVDSKSKERTLTITASTMEDIERAKDMIIDTIRRNMSPMRTDMSIPPPNQYSGMSSENQSIPSQQNTANIDEDDDDDDEDIKLEQTSDGKLTFHCDDPELLAAAQEALSAYLRVRARPSAEEREKKKERRKSMPLQQTARDQQEPVMLKPAKTFHGSTPNLADGLAATTTVVVASIPQPMVPNVHASGDNPIRYNRDTLMTARDTKRAPIPDEMLQEINRVAPDILIA
Protein: DNA replication licensing factor MCM7 (EC 3.6.4.12) (A0A8I5ZTF3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU365012}.
Interaction partners:
Sequence:
MALKDYAIEKEKVKKFLQEFYYDDELGKKQFKYGTQLVHLAHREQVALYVDLDDVAEDDPELVDSICENAKRYSRLFADVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELYFQGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFIKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAQGLLSETYLEAHRVVKMTKSEDDVSGAGELSAEELKQIADVIFATVRELVSGGRSVRFSEAEQRCISRGFTPAQFQAALDEYEELNVWQVNTSRTRITFV
Protein: SUZ domain-containing protein (Q565A8)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSKENVVADSWDDADADPVKELMDKVEKVKLLQRKEEKKEAFFEKVKAEESSGVVSKLQTEEGLGPSAEEPKRVFLRRPKDGFAASENVIEASPPTSADTEEQPVTNVRSRSHHKLNQKEKQPAPTYEERQAAYQAARNRILGTEYKPDNQEIKEIKFIDRSKSPETLKMTQQNMVEHYGEELSRELMEQPAEIVPPERQYTPDFTLQQPPPSVSESGGVYNGPPGFQQKQPNFQPTLQQQSLHQQQYLDNQYMMQMNVQIPIQYHNQTQHQFVPHEASAISTTSQNSNGDGQNDQAIYYYQAPTQQPMNYIPYNLPNMAYPPPNFQPQGQLHHQMNAGQLHQIQQQQQQCQQIQHQPPQQHQQVINGQVMNQQNQRNQVNSYPQQNGAGRGQNRQPMMYQMPCNSGPTAKPPPLMNQMQNRCMTNNGQNYQNRNMQQQGQQRSYSSQPQNGQFYQNGNSNQNNPNNGRKQQHQPQQQQNKSGKFGQNRNDMQKNNYQPNLQQPPMSQNPIPFGCPPRNVNAIREQHANNGSPNTGAGILGPHPMMSASQWPALQQNRPQ
Protein: Protein doublesex (P23023)
Organism: Drosophila melanogaster (Fruit fly)
Function: Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female-specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body.
Subcellular location: Nucleus.
Interaction partners:
- Male-specific sperm protein Mst84Dd
- Paired box protein Pax-6
- AT27166p
- Uncharacterized protein, isoform C
- GEO11848p1
- Transformer-2 sex-determining protein
- Female-specific protein transformer
- Sex determination protein fruitless
- Protein sex-lethal
- Homeobox protein abdominal-B
Sequence:
MVSEENWNSDTMSDSDMIDSKNDVCGGASSSSGSSISPRTPPNCARCRNHGLKITLKGHKRYCKFRYCTCEKCRLTADRQRVMALQTALRRAQAQDEQRALHMHEVPPANPAATTLLSHHHHVAAPAHVHAHHVHAHHAHGGHHSHHGHVLHHQQAAAAAAAAPSAPASHLGGSSTAASSIHGHAHAHHVHMAAAAAASVAQHQHQSHPHSHHHHHQNHHQHPHQQPATQTALRSPPHSDHGGSVGPATSSSGGGAPSSSNAAAATSSNGSSGGGGGGGGGSSGGGAGGGRSSGTSVITSADHHMTTVPTPAQSLEGSCDSSSPSPSSTSGAAILPISVSVNRKNGANVPLGQDVFLDYCQKLLEKFRYPWELMPLMYVILKDADANIEEASRRIEEARVEINRTVAQIYYNYYTPMALVNGAPMYLTYPSIEQGRYGAHFTHLPLTQICPPTPEPLALSRSPSSPSGPSAVHNQKPSRPGSSNGTVHSAASPTMVTTMATTSSTPTLSRRQRSRSATPTTPPPPPPAHSSSNGAYHHGHHLVSSTAAT
Protein: YTH domain-containing protein ECT1 (Protein EVOLUTIONARILY CONSERVED C-TERMINAL REGION 1) (Q3MK94)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability (By similarity). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16113215}. Cytoplasm {ECO:0000269|PubMed:16113215}. Note=Localizes predominantly in the nucleus. {ECO:0000269|PubMed:16113215}.
Interaction partners:
- CBL-interacting serine/threonine-protein kinase 1
- FKBP12-interacting protein of 37 kDa
- RNA demethylase ALKBH9B
- Small nuclear ribonucleoprotein SmD1a
- Small nuclear ribonucleoprotein SmD1b
- Small nuclear ribonucleoprotein SmD3b
- N
Sequence:
MAGAASSDRLVTSFPLLDTADLFQDLSLGSDANEVPMNFTKGSFQHPYGHAPYGASSHGSERRPNMNAGNLLNGGDSIGSYPWGYIPANYPSGGYPDPRFGYDRNSNHSSFSHLMNPHSSQEVPSFDQLGYNDHLYSNHGLYGLYGNVIDSGHAYGTFGYDSWKLGRGWYPVDGYRKTRSFNHGRGYSDEKADRLNELCRGPRSSDFKNPQVLNSSMLDAMKQDVSAVDLQRYNGENFPESFVKAKFFVIKSYSEDDVHNCIKYGAWSSTPTGNKKLNAAYYEAKENSQECPVYLLFSVNASGQFVGLAEMVGPVDFNKTMEYWQQDKWIGCFPVKWHIIKDIPNSLLRHITLANNENKPVTNSRDTQEVNLEHGTKIIKIFKEYMSKTCILDDYKFYETRQKIIRDKKIKQKKQALDGASGETINLS
Protein: Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN) (Q9NR81)
Organism: Homo sapiens (Human)
Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Rho-related GTP-binding protein RhoB
- Rho-related GTP-binding protein RhoC
- Transforming protein RhoA
- Rapamycin-insensitive companion of mTOR
- Cell division control protein 42 homolog
Sequence:
MVAKDYPFYLTVKRANCSLELPPASGPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV
Protein: Cytoplasmic FMR1-interacting protein homolog (Gut on exterior protein 2) (O44518)
Organism: Caenorhabditis elegans
Function: Required for initial steps of body morphogenesis. May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11877381}. Note=Enriched at cell boundaries. {ECO:0000269|PubMed:11877381}.
Interaction partners:
- Membrane-associated protein gex-3
- Wiskott-Aldrich syndrome protein family member
- SH3 domain-containing protein
- Protein BRICK1
- Eukaryotic translation initiation factor 4E-3
- Eukaryotic translation initiation factor 4E-2
- Eukaryotic translation initiation factor 4E-1
- Eukaryotic translation initiation factor 4E-5
- Nucleosome assembly protein 1-like 1
- Ras-related protein ced-10
Sequence:
MNANVTVDDAISNVNLLDTLAIPDDLPDIEARALPLLYRSNFDTNFEDRSAFVTGIAKYSEEATRHAQFNDMLSEGLQHAANMYTWRCCSRAVPMAKSNDQPNRTEINEMVVEVLKPEVSKLGSFMRFTLTAIQRFCEEVRRLCHSEKRRDFVSEAYLLTLGRFINMFAVLDELKNMKASIKNDFSTFRRASQFLTAMSDTQAVHDMQNLSMFLATQNKIKDDLKLQMKTIEGYEELLCDVVNICAHMYEHQLYLSPNEKHMFVKVIAFSLFLMDGDAANVAKLDQKKRLSISRLDKIFKTLEVVPLYGDMQIQPFAFVRRSSHYEPSKWPLSDKESDRCHVNIVEKVQSIRSDHESYVTQFAKINNEVAICDRPGNDSENREITSLALSGIQLLCQWSCAVVETISWKLLNPTNPKDNRECPENAEEYERATRYNYSPAEKTALIQIIAMIKGLQSMLGKTESDMSNSTRKCVYVELQAFIHHTINEPLQKAVKHKKDLLASILQSVKDSISDAGNELNRMTDVKGKKKSSAPKGDSANSSSSDIRIPRRTAAPGSTQLYMARTQLESLISDKLCGGKKILRKELDSKTIEKISVFLRKSAHWPALFRLSDSMTEAGELSQLWFREFYLEMTMGQRIQFPIEMSMPWILTDYILSCNEPSLIESALYQLDLYNDAAQYSLFNFNKQFLYDEVEAEVNLCFDQFVYKLSEMVFTHYKQLASCMLLDKRFKAEILRSGTMIRSPSAARFESLLQQRHVQLLGRSVDLNRVVSQRVNMALLKALDAAIWKFESEPLSSIVELDMLIDTNRLCHTLLSDVLHSIAPFDDLFQEANHAVNSPHGRITLHVFWELNYDFVPNFVYNGSTHRFVRARHVFRKTPAREKPPQVGQVYYWGSKSLMAAFMNICNAYSQCIGTQHLKAITRLLHYQGIAVILDELLKMTNRLLNDKIRRHVRNVFNMMPKVCKLPRSDYGSNALLQYYVHHLEAVGKYPELKSEFCQDLRELGNMIVFCQQLEVALGQEEAHDLFLAAAYTGTVPQPPARNAQEQMKQLAKLEDKYSRIHLTEIIDKISPDDGQAAIAKDAELMTKERLCCGLNAFENFLVRIKQMLAADDIWTGGYPTNGVFWIDECVEWYRVYSALQFFLCQPTRDDNEVYAEELFGDSLQWGGLTLITLLGQHRRFEVLDFCYHLHRVNKADGKDEVISGIRLAKMVERIRRFQLLNNQIFIILENQLNENNDDPNERVREFAPPVHPNYANHAARRQ
Protein: Clotting factor C (FC) (EC 3.4.21.84) (Limulus factor C) [Cleaved into: Clotting factor C heavy chain; Clotting factor C light chain; Clotting factor C chain A; Clotting factor C chain B] (P28175)
Organism: Tachypleus tridentatus (Japanese horseshoe crab)
Function: This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system which may play important roles in both hemostasis and host defense mechanisms. Its active form catalyzes the activation of clotting factor B.
Subcellular location: Secreted {ECO:0000305}. Note=Secreted in hemolymph (PubMed:2007602). Localizes in large granules of hemocytes (PubMed:2007602). {ECO:0000269|PubMed:2007602}.
Interaction partners:
Sequence:
MVLASFLVSGLVLGILAQQMRPVQSRGVDLGLCDETRFECKCGDPGYVFNVPMKQCTYFYRWRPYCKPCDDLEAKDICPKYKRCQECKAGLDSCVTCPPNKYGTWCSGECQCKNGGICDQRTGACTCRDRYEGAHCEILKGCPLLPSDSQVQEVRNPPDNPQTIDYSCSPGFKLKGVARISCLPNGQWSSFPPKCIRECAKVSSPEHGKVNAPSGNMIEGATLRFSCDSPYYLIGQETLTCQGNGQWSGQIPQCKKLVFCPDLDPVNHAEHQVKIGVEQKYGQFPQGTEVTYTCSGNYFLMGFNTLKCNPDGSWSGSQPSCVKVADREVDCDSKAVDFLDDVGEPVRIHCPAGCSLTAGTVWGTAIYHELSSVCRAAIHAGKLPNSGGAVHVVNNGPYSDFLGSDLNGIKSEELKSLARSFRFDYVSSSTAGRSGCPDGWFEVEENCVYVTSKQRAWERAQGVCTNMAARLAVLDKDLIPSSLTETLRGKGLTTTWIGLHRLDAEKPFVWELMDRSNVVLNDNLTFWASGEPGNETNCVYLDIRDQLQPVWKTKSCFQPSSFACMMDLSDRNKAKCDDPGPLENGHATLHGQSIDGFYAGSSIRYSCEVLHYLSGTETVTCTTNGTWSAPKPRCIKVITCQNPPVPSYGSVEIKPPSRTNSISRVGSPFLRLPRLPLPLARAAKPPPKPRSSQPSTVDLASKVKLPEGHYRVGSRAIYTCESRYYELLGSQGRRCDSNGNWSGRPASCIPVCGRSDSPRSPFIWNGNSTEIGQWPWQAGISRWLADHNMWFLQCGGSLLNEKWIVTAAHCVTYSATAEIIDPSQFKIYLGKYYRDDSRDDDYVQVREALEIHVNPNYDPGNLNFDIALIQLKTPVTLTTRVQPICLPTDITTREHLKEGTLAVVTGWGLNENNTYSEMIQQAVLPVVAASTCEEGYKEADLPLTVTENMFCAGYKKGRYDACSGDSGGPLVFADDSRTERRWVLEGIVSWGSPSGCGKANQYGGFTKVNVFLSWIRQFI
Protein: ESX-1 secretion-associated protein EspG1 (P96210)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:B2HSU5}.
Interaction partners:
- ESX-1 secretion system protein EccA1
- PPE family immunomodulator PPE68
- ESX-1 secretion-associated protein EspE
- ESX-1 secretion-associated protein EspF
- ESX-1 secretion system ATPase EccB1
- ESX-1 secretion-associated protein EspH
- ESX-1 secretion system protein EccCa1
- ESX-1 secretion system protein EccCb1
- ESX-4 secretion system ATPase EccB4
- ESX-2 secretion system protein EccA2
Sequence:
MTGPSAAGRAGTADNVVGVEVTIDGMLVIADRLHLVDFPVTLGIRPNIPQEDLRDIVWEQVQRDLTAQGVLDLHGEPQPTVAEMVETLGRPDRTLEGRWWRRDIGGVMVRFVVCRRGDRHVIAARDGDMLVLQLVAPQVGLAGMVTAVLGPAEPANVEPLTGVATELAECTTASQLTQYGIAPASARVYAEIVGNPTGWVEIVASQRHPGGTTTQTDAAAGVLDSKLGRLVSLPRRVGGDLYGSFLPGTQQNLERALDGLLELLPAGAWLDHTSDHAQASSRG
Protein: E3 ubiquitin-protein ligase RNF183 (EC 2.3.2.27) (Q96D59)
Organism: Homo sapiens (Human)
Function: Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29507230}; Single-pass type IV membrane protein {ECO:0000305|PubMed:29507230}. Endoplasmic reticulum {ECO:0000269|PubMed:26567849}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q8QZS5}. Lysosome membrane {ECO:0000250|UniProtKB:Q8QZS5}.
Interaction partners:
- Fetal and adult testis-expressed transcript protein
Sequence:
MAEQQGRELEAECPVCWNPFNNTFHTPKMLDCCHSFCVECLAHLSLVTPARRRLLCPLCRQPTVLASGQPVTDLPTDTAMLALLRLEPHHVILEGHQLCLKDQPKSRYFLRQPQVYTLDLGPQPGGQTGPPPDTASATVSTPILIPSHHSLRECFRNPQFRIFAYLMAVILSVTLLLIFSIFWTKQFLWGVG
Protein: Large ribosomal subunit protein bL21m (39S ribosomal protein L21, mitochondrial) (L21mt) (MRP-L21) (Q2TBS2)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11551941}.
Interaction partners:
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL12m
- Ribosomal protein
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein uL5
Sequence:
MAAAVAARALPVTFGRLAFACSRSVLRASGPGAASQWSASRRFSSQSASSPQGYVPKTSLSSPPWPEVVLPDPAEEARHHAEVVEKVNELIAGGQYGRLFAVVHFASHQWKVTSEDLILIENKLDIACGERIRMEKVLLVGADDFTLLGRPLLGKDLVRVEATVIEKTESWPRVNMRFQKRKNYKRKRIIVNPQTVLRINTIEIAPRLC
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q8IC06)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- EKC/KEOPS complex subunit CGI121
- N
- tRNA N6-adenosine threonylcarbamoyltransferase
- tRNA N6-adenosine threonylcarbamoyltransferase
Sequence:
MSAGSDARIYRCTFIKKEAVKKVIYRKYYRHKKIDTKIRKLRVSNEIKFTKKLASLNIDVPYIYFVDAKEKSLYFEYVKGCTINFILKNLKEYEPKIPICVGMVLAKIHNGNIIHGDYTTSNLILRNSFIQQNNLLDLKNNNSPYNFSDLENVKLCVIDFGLSFLSSSIEDKAVDLFVLLKTIKSFHSEFPSLEEDILEGYKMKSDNVNDIFTKLEIVKQRGRKRPMVG
Protein: Bleomycin hydrolase (EC 3.4.22.40) (X2JEJ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH02722p
- CG32712
- Tripeptidyl-peptidase 2
Sequence:
MFWAVRRSVTQIKINSPKLSQNPNTYRNRIPYPQQQQEPAMYYSKESVQTHTISGERCQSHLLAADNNSGSGGGGSGGGGAGNNNSANSGKNSTHRFAETSVITNQLLEKWRKNFYSEPKNLLAQNVCSRVDPFDVCLSRKALETTNHVFNYKVETEGKPVTNQRSSGRCWLFAALNCIRLPFMKNYNLDEFEFSQAFLFYWDKIERCNYFLNNVVKTAQRGEKVDGRLVSFLLLDPTSDGGQWDMLVNLITKHGLMPKKCFPESFSCESSLRMNAILKSKLREYARNLRVLMEKNPTDEEIACKIQEQMAEIYKVVGICLGIPSETFTWEYYDKSKNYQSIGPVSSLEFYERYVKPHFNVEDKVCLVTDPRPTSSYDQAYTVDCLGNVVGGRPVLYNNQSVELLLAVVTKSLKAGEAVWFGCEVSKRFASKQGIEDVDVHDFKLVFDIDIQTTFSKADRLIYGESAMTHAMVFTAVSVDKSGVAQKLRVENSWGEDRGEKGYLVMNADWFREFGFEVVVDKKYVPEDVLRVFDMDPIVLPAWDPMGTLAQ
Protein: Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) (Q9P7D2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity).
Interaction partners:
- Protein phosphatase PP2A regulatory subunit A
- Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit
- Leucine carboxyl methyltransferase 1
- Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
- Uncharacterized protein C7D4.09c
- Multifunctional tryptophan biosynthesis protein
Sequence:
MAFRKEELSQTLYENESEQSSETKELMLNNEESLSDWRNYFDEKLTIPGESGALNGTINGYLTLPQPDGCLLVLQHGAGSSAMSFAPVTQELLSNSDNKVGFLALDLRAHGETTLEPESDMSLETLSKDFTHAVSYVQRMFELDEKIILVGHSLGGAICAYCAFQKTIPNTSGLVVIDVVEGTAMEALGFMKTYLSNRPTSFKSIDDAISWHIKTLVTRNRLSACITVPSLLVQQEDGTFVWRTDLYKTSPYWMDWFKGLSDKFLRAPYGRMLIVAGTDRLDKTLTIGQMQGKYQLEILPETGHFVHEDVPAKISSLLLNFWHRNQPLVLPPKVGATPVLQ
Protein: Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (Q86Z23)
Organism: Homo sapiens (Human)
Function: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MVLLLLVAIPLLVHSSRGPAHYEMLGRCRMVCDPHGPRGPGPDGAPASVPPFPPGAKGEVGRRGKAGLRGPPGPPGPRGPPGEPGRPGPPGPPGPGPGGVAPAAGYVPRIAFYAGLRRPHEGYEVLRFDDVVTNVGNAYEAASGKFTCPMPGVYFFAYHVLMRGGDGTSMWADLMKNGQVRASAIAQDADQNYDYASNSVILHLDVGDEVFIKLDGGKVHGGNTNKYSTFSGFIIYPD
Protein: Pentatricopeptide repeat-containing protein At2g41720 (Protein EMBRYO DEFECTIVE 2654) (Q8RWS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytosolic sulfotransferase 1
- Cytosolic sulfotransferase 5
- Protein THYLAKOID ASSEMBLY 8, chloroplastic
- CRS2-associated factor 2, chloroplastic
- DEAD-box ATP-dependent RNA helicase 3, chloroplastic
- Small ribosomal subunit protein uS12cz/uS12cy
- Small ribosomal subunit protein uS12m
- Ribosomal protein S12
Sequence:
MATVTNFKLVTPPESSRADKPGATKASDAFQEKKSVSVNYDRGEHEVSVNIGGLRKADIPRRYRIRVENDRFQKDWSVSEVVDRLMALNRWEEVDGVLNSWVGRFARKNFPVLIRELSRRGCIELCVNVFKWMKIQKNYCARNDIYNMMIRLHARHNWVDQARGLFFEMQKWSCKPDAETYDALINAHGRAGQWRWAMNLMDDMLRAAIAPSRSTYNNLINACGSSGNWREALEVCKKMTDNGVGPDLVTHNIVLSAYKSGRQYSKALSYFELMKGAKVRPDTTTFNIIIYCLSKLGQSSQALDLFNSMREKRAECRPDVVTFTSIMHLYSVKGEIENCRAVFEAMVAEGLKPNIVSYNALMGAYAVHGMSGTALSVLGDIKQNGIIPDVVSYTCLLNSYGRSRQPGKAKEVFLMMRKERRKPNVVTYNALIDAYGSNGFLAEAVEIFRQMEQDGIKPNVVSVCTLLAACSRSKKKVNVDTVLSAAQSRGINLNTAAYNSAIGSYINAAELEKAIALYQSMRKKKVKADSVTFTILISGSCRMSKYPEAISYLKEMEDLSIPLTKEVYSSVLCAYSKQGQVTEAESIFNQMKMAGCEPDVIAYTSMLHAYNASEKWGKACELFLEMEANGIEPDSIACSALMRAFNKGGQPSNVFVLMDLMREKEIPFTGAVFFEIFSACNTLQEWKRAIDLIQMMDPYLPSLSIGLTNQMLHLFGKSGKVEAMMKLFYKIIASGVGINLKTYAILLEHLLAVGNWRKYIEVLEWMSGAGIQPSNQMYRDIISFGERSAGIEFEPLIRQKLESLRNKGEGLIPTFRHEGTLL
Protein: Photosystem II 22 kDa protein 2, chloroplastic (22 kDa protein of photosystem II 2) (Photosystem II subunit 2) (OsPsbS2) (Q0J8R9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in high light-mediated energy-dependent nonphotochemical quenching (NPQ, qE) and thermal dissipation (TD) thus regulating energy conversion in photosystem II and protecting from photoinhibition. Seems also to regulate quantum yield of electron transport in fluctuating light conditions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250|UniProtKB:Q9XF91}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Photosystem II 22 kDa protein 1, chloroplastic
- Photosystem II CP47 reaction center protein
- Glyceraldehyde-3-phosphate dehydrogenase
- Chlorophyll a-b binding protein
- Photosystem II D2 protein
- Photosystem II reaction center protein H
- Photosystem II protein D1
- Chlorophyll a-b binding protein
- Photosystem I reaction center subunit V, chloroplastic
- Photosystem II CP43 reaction center protein
Sequence:
MALQQSMAMPMMVVSDLGTAPRSSPMVQLQRMKKHLVVVAAFKSRTKASPKVDKSNKNKSIVEDGIFGTSGGIGFTKENELFVGRVAMLGFAASLLGEAVTGKGILAQLNLETGIPIYEAEPLLLFFILFTLLGAIGALGDRGRFVDDATGLERAVIPPGKGFRAALGLSEGGPLFGFTKANELFVGRLAQLGIAFSLIGEIITGKGALAQLNIETGVPINEIEPLLLFNILFFFFAAINPGTGKFVTDDNDDQ