wanglab/gogpt-training-data huggingface dataset:
Protein: Calmodulin-interacting protein 111 (CaM-interacting protein 111) (ATPase family AAA domain-containing protein CIP111) (Q9LET7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Expressed protein family protein)
- DExH-box ATP-dependent RNA helicase DExH9
- DExH-box ATP-dependent RNA helicase DExH10
- DEAD-box ATP-dependent RNA helicase 16
- MIF4G domain-containing protein / MA3 domain-containing protein
- Nucleolar complex-associated protein 3
- Ribosome biogenesis protein BOP1 homolog
- Ribosome production factor 2 homolog
- Mitochondrial substrate carrier family protein
- Probable GTP diphosphokinase CRSH, chloroplastic
Sequence:
MPSKKKQSRTPSRLSNSEPPASPRTPASSTTSRDTDSINEEELRRSIEEASAAFPCLLGKSAIIARVADVASESIRGSKIWLSETSMVAASLSPGSTVSVSLASPESRFSRSFPLSSIKAEYGDDSESIIADEPGNYFVLTTVFSSSKVFKDAVRISLNLCYGLGCPVSGRTVFVYPVSGPSLSDQFNGNGRSRYDDVNHLSLLACKELCLELTPFRNMLQAKNAFESSYEQNGNGNSTPKTPANLQKFSSPRPKSPVSPIIEDSVFSCKQRFSSESSIDLREVLSNESSKKLLQICASSWLYPCSLLYGNFVSVPILSEICIFCVKRADKRPSDTSNRNHAFMINQETKVYLHHTLDLASEIQGRTFVQGLQFDEGENVGCEISKLGGLSKEYAILRDIIDSSSIKNSLSSLGLRPTKGVLIHGPPGTGKTSLARTFARHSGVNFFSVNGPEIISQYLGESEKALDEVFRSASNATPAVVFIDDLDAIAPARKEGGEELSQRMVATLLNLMDGISRTDGVVVIAATNRPDSIEPALRRPGRLDREIEIGVPSSTQRSDILHIILRGMRHSLSNIQVEQLAMATHGFVGADLSALCCEAAFVCLRRHLDQSSSSSNLPLEEAPIAESSSNMSDISSDSSDSASSCITISATTSGAQRSFSLDETVSLVADDIQNNGNSCSEQMLRKQGEHTLSVGFEDFENAKTKIRPSAMREVILEVPKVNWEDVGGQNEVKNQLMEAVEWPQKHQDAFKRIGTRPPSGILMFGPPGCSKTLMARAVASEAKLNFLAVKGPELFSKWVGESEKAVRSLFAKARANAPSIIFFDEIDSLASIRGKENDGVSVSDRVMSQLLVELDGLHQRVGVTVIAATNRPDKIDSALLRPGRFDRLLYVGPPNETDREAILKIHLRKIPCSSDICLKELASITKGYTGADISLICREAAIAALEESLEMEEISMRHLKAAISQIEPTEILSYKALSEKFQRLVHTDPQREEEVTQPGNKSRSLWTPLRSVAMFLRRHIAS
Protein: Protein AF-9 homolog (Q59LC9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00376}.
Interaction partners:
- SWR1-complex protein 4
- Enhancer of polycomb-like protein 1
- Chromatin modification-related protein EAF3
- Chromatin modification-related protein EAF6
- RuvB-like helicase 1
- Histone acetyltransferase
- RuvB-like helicase 2
- Chromatin modification-related protein YNG2
- Chromatin modification-related protein EAF7
- Histone H2A.Z
Sequence:
MSSTHSRRIKFVSISVPILYGNHAIKLTPEKRKPTTPPEHTHEWTVFFKPVLGDIDLTPLIKKVTFKLHETYENPVRTLESPPYQVTETGWGEFEIIIKLHFQPGVELGINEKNFQIFHALKLHPYNPQAPQAQQPQVQQSQAQPPQQQFGGEGGSVGTVIRERENGEVHSVLYDELVFNEPTEKTFEILTSKPVNLIPYKLSNLDKRDQEYIRPDEIDELNRMDIYIDKVKQEIENQRNQYKLLEQEKLALLQ
Protein: Elongation factor 2 (EF-2) (EC 3.6.5.-) (P58252)
Organism: Mus musculus (Mouse)
Function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P13639}. Nucleus {ECO:0000250|UniProtKB:P13639}. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. {ECO:0000250|UniProtKB:P13639}.
Interaction partners:
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL5
Sequence:
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLSAAERAKKVEDMMKKLWGDRYFDPANGKFSKSANSPDGKKLPRTFCQLILDPIFKVFDAIMNFRKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGVVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKARARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL
Protein: Retinol-binding protein pinta (Prolonged depolarization afterpotential is not apparent) (Q9VD09)
Organism: Drosophila melanogaster (Fruit fly)
Function: Retinoid-binding protein which shows highest affinity for all-trans retinol. Can also bind all-trans forms of retinoic acid and retinal, but has lower affinity for cis form retinoids. Required in retinal pigment cells for rhodopsin biosynthesis.
Interaction partners:
- FI02050p
- Neither inactivation nor afterpotential protein G
- Carotenoid isomerooxygenase
Sequence:
MWSRSSSSKRQVATTDGDPERVLAQVQDLSDWLVANPQINGCNTFENLHFFLRTSKFDVERAKKKLKTFYQMRAERTEWFDNRDPQLPEIQDLLKLGVFLPIGPDAEQRMVVVIRTAAHDPKLHSQNNVFKTSKMILDLLLKLDPETCARGMVAILDMQGVQLGHALQMNPKLIKRSVESWTAYPCQPKLLEFTNAPRHVNFFLNTFRIFMTPKIRSRLFVRREGTSVSCDQLPKELGGQGLSYMELSVKWKQLVEENADFYVEQDKYKSKLK
Protein: Fe(3+)-Zn(2+) purple acid phosphatase 12 (PAP) (EC 3.1.3.2) (Iron(III)-zinc(II) purple acid phosphatase 12) (Q38924)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted.
Interaction partners:
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 7
- Fructokinase-like 1, chloroplastic
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 10
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 14
- Thioredoxin-like protein CITRX, chloroplastic
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 12, chloroplastic
- PLASTID TRANSCRIPTIONALLY ACTIVE protein 6, chloroplastic
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE homolog, chloroplastic
- Superoxide dismutase 3, chloroplastic
- Plastid transcriptionally active 3
Sequence:
MSSRSDLKIKRVSLIIFLLSVLVEFCYGGFTSEYVRGSDLPDDMPLDSDVFEVPPGPNSPQQVHVTQGNHEGNGVIISWVTPVKPGSKTVQYWCENEKSRKQAEATVNTYRFFNYTSGYIHHCLIDDLEFDTKYYYEIGSGKWSRRFWFFIPPKSGPDVPYTFGLIGDLGQTYDSNSTLSHYEMNPGKGQAVLFVGDLSYADRYPNHDNNRWDTWGRFVERSVAYQPWIWTAGNHEIDFVPDIGEIEPFKPFMNRYHTPHKASGSISPLWYSIKRASAYIIVMSCYSSYGIYTPQYKWLEKELQGVNRTETPWLIVLVHSPFYSSYVHHYMEGETLRVMYEQWFVKYKVDVVFAGHVHAYERSERVSNIAYNIVNGLCEPISDESAPIYITIGDGGNSEGLLTDMMQPQPKYSAFREASFGHGLLEIKNRTHAYFSWNRNQDGNAVAADSVWLLNRFWRAQKKTWLDAF
Protein: Flowering time control protein FCA (OsFCA) (rFCA) (B8BCZ8)
Organism: Oryza sativa subsp. indica (Rice)
Function: Plays a major role in the promotion of the transition of the vegetative meristem to reproductive development (By similarity). Required for RNA-mediated chromatin silencing of a range of loci in the genome. Cotranscriptionally recognizes aberrant RNA and marks it for silencing. Controls alternative cleavage and polyadenylation on pre-mRNAs and antisense RNAs (By similarity). Regulates flowering time, seed size and cell volume, probably via the modulation of cell size.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6K271}.
Interaction partners:
Sequence:
MHRGGDRSTDPSSGPAPGSRGGGDGRFGRGPSRWSSGGGGGGSGSPPHRFSRGGGGGGGDGGGGGGGGGRFHPYRGPSDHSGGGGYRSGGGGEYGEPGSGPRHRYGSGRGDHSDHDNRNNYVKLFIGSVPRTATEDDVRPLFEEHGDVVEVALIKDRKTGEQQGCCFVKYATSEEAERAIRALHNQYTLPGAMGPIQVRYADGERERHGAIEHKLFVASLNKQATAKEIEEIFAPYGHVEDVYIMKDGMRQSRGCGFVKFSSREPALAAMSALSGNYVMRGCEQPLIIRFADPKRPRPGESRGGPAFGGPGFSPRSDAALVIRPTANLDEPRGRHMPPDSWHPSSPRSAPHQFNNFGSDNPMAPKGSTVTSTTDTATFRPQMFSGNGSLSSQTAVPSSSHMGMNPPPMAQGHHLGGQQIPPLQKLPGLPQNFPVQLQNNQQGQPLQGPAQQIGQLQVPQSMGPGSFGQNMLSGQLPVSQPLMQQNASVGAVQAPSAVSNSMQAIPGQQHLPSNVAPQMLQQPVQQMPSQAPQLLLQQQAALQSSYQSSQQAIYQLQQQLQLMQQQQQSNLNHQQPTQGQPVQSSNPGAPNAIIPSNINTIPQQATSPAVPLTCNWTEHTSPEGFKYYYNSITRESKWDKPEEYVLYEQQQQQQQQQKLLLLQQHQQKLAMQQLQSPPQAQTHPAMQPVQQIPQAQQGQQQMQMKQQELNYTQLQTPGAIDPSRIQQGIQSAQERAWKS
Protein: V-type proton ATPase subunit a (A0A494B9E3)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGSMFRSEEVALVQLLLPTGSAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVDVRRCEELEKTF
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (Q9U983)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSKRHRLTPFTIAKEPEAAIVPPRNLDSRATIQIGDRTFDIDADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFLHDLRMEESVLGKIAMSVVRALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFVARILDLPDAAGAVG
Protein: Grunge, isoform J (M9PHT1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cadherin-related tumor suppressor
- Protein dachsous
- Histone deacetylase HDAC1
- Protein tailless
- Segmentation protein even-skipped
- Scribbler, isoform J
Sequence:
MAASTQGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESRWSPGVVADGDLLMFLRAARSMAAFQGMCDGGLEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKCPVSKGIDKKWTEDETKKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQSALRRNRVTRANNSNSNTPPKKEDTPEPQTATTATAAATAASETASRSSPAVSKEENSSLTEDDASECDSDSSLTHKRDESPSRMRTRNKQQNNNSSTSSGNNTAGNGGGNATSISSGSTGGGAAGGNSSSKDQSANAVANGKRPKRGSETPDVSGGASVDSPKTPTKAVAESSANKRKGGKQDTPNKKKRTEQESNEPSAHEENAIKEKRKRPDSPVESMNSDSRPDSVLDDGESNTTDTTTAEQQSTKDSKETVSCKEEREMVTNDLEAKAEEKAIKAEALAEDSKDSAIKNMDEETNIQAPSSADTSLVDGPNPNALPSPVAAPITMKVPTIATVEALNASVDRKEAIEKMESCDSDPEMLKKLATIKQEVSPQQQQHMQQQSQQQMQQQLAPVGIPQPPSCPPSESVYIKKEPMEDSMDATCNQNSNEPQDLKVKIEIKNEDALKHSAGGLPPSGPCAPPSALHPLSGAPVESGQEPLHLQHMPHGQVTTQPPPGYLIDGQLKYGPSGQGVPPQPPQLHSDAAGGVSGAPPGAPTTPQKYPPEMEMKFAPQDLKYPPPPPLDALKYSQEMQAAAAAAAAAGKYDMKYMMEQQGKYNVELSAAHQPPSKPGYQDSLKIPDIKPGFGHLPHNVGSPLDAAHKYGPPPTSQESQQQQPQPPAHQVPPGATPPPGIAMPKPHYQHDVQTPPLGRPFEPTGLMLKYGDPLAAKYGPPQDLKYPMPPVSQAGPADVKPYGGENLIKSSPYGPPPESPIDASARSTPGQDSQGSNSNSQPPSMPPQPQQFQSPHPSPHMPSPAGGGLPPGMHPQNLIHGPPPGAAGGSGPQPPPPPTSLHQPTPTSAGPPSLQHGLHPGHQHSQLSVASSIPPSSIGIPPTLSTMAPSHMHPHLHPHAHLQGLHRPHDLPPSMHPHAPMPLSLQGHPQHGHGLPPSHTSQQQQQQQQQQQPGGPAGTVRTPSPAQQPPRSMHDPQSSREPPTSQPSTTMAGSSGPGGPPPQQSPHAHRTSPLPGLAGSGPPPPGLIGHPMAIHPHLAHLPPGHPAHAALAHPGHHLLSHSIAGLGPGGGPIALLAGPGGLGGIPESALSRRTPPSHLPHSHASSAPLTAHSVASMTSTSMSLTTSTVPSSAFSRASPSVQISSSGGGPSGPGSVGPGGMPNSSAAAAAAAAAHRAASPASSVSSLSRQSPLHPVPQSPLSHHPSSSALSAAAAAVAERDRHALMRQQSPHMTPPPVSNASLMASPLSKMYAPQPGQRGLGTSPPPHLRPGASPPVIRHPQMPLPLPLIAPGGGIPQIGVHPGQSPYPHPLLHPSVFYSPHHHPFNSPYGYAPYGPGFPAYMKPPPQPGQLDPAAVMAAHHAGLQGPPPQQMRQDEQNAAAAAAQAAAEKQHQAAAAAAAQQHKAPQQQQPGGMPPNKPPTPKTPQGPGGGMPPGMGGPGTPTGLPPGAYPGSHMPGYPQGPPHGSPFAPQDGQPHGLKPTSHMDALRAHAHSANSAGMGGGHHPTEPLPIDIEPDPEPEIPSPTHNIPRGPSPEAKPDDTECHRSQSAIFVRHIDRGDYNSCTRTDLIFKPVADSKLARKREERDRKLAEKERERRQQQQQQQQQQQQQQAAAAQQAAQQAKMKAELKPPYADTPALRQLSEYARPHVAFSPVEQMVPYHHPMGPMYRERELEEIKNAQAAAASQSRLDPHWMEYYRRGIHPSQFPLYANPAISQMERERLGIPPPHHVGLDPGEHMIRLTREYHAHSHTHLHLPLHPQPQPPEAGFQLPPNVGQYPRPNMLIPREPHSDVLLRMSYADQLQYLQAAEFQRQSLHDQYFRNQLR
Protein: Biotin sulfoxide reductase (BDS reductase) (BSO reductase) (EC 1.-.-.-) (L-methionine-(S)-sulfoxide reductase) (Met-S-SO reductase) (EC 1.8.4.13) (P20099)
Organism: Escherichia coli (strain K12)
Function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin. Also exhibits methionine-(S)-sulfoxide (Met-S-SO) reductase activity, acting specifically on the (S) enantiomer in the free, but not the protein-bound form. It thus plays a role in assimilation of oxidized methionines.
Interaction partners:
- Cytochrome c-type protein TorY
- Biotin synthase
- Bifunctional ligase/repressor BirA
- Cytochrome c-type protein TorC
- Protein-methionine-sulfoxide reductase catalytic subunit MsrP
- Free methionine-R-sulfoxide reductase
- Anaerobic dimethyl sulfoxide reductase chain C
- Molybdopterin molybdenumtransferase
Sequence:
MANSSSRYSVLTAAHWGPMLVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAEICGVGAAKIRELAAIFHQNTTMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRSAVLSSMQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMNRHFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERFIRFADFCRDPLAHPLKTASGKIEIFSQRIADYGYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDAQERGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS
Protein: Putative aluminum-activated malate transporter 3 (AtALMT3) (Q9LPQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Malate transporter.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative aluminum-activated malate transporter 11
- Tonoplast dicarboxylate transporter
- Eukaryotic LigT
- Eukaryotic aspartyl protease family protein
- Calcineurin-like metallo-phosphoesterase superfamily protein
- Forkhead box protein G1
- Transmembrane protein
- Transmembrane protein
- At5g05950
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
Sequence:
MAAPKLESFRRGSMFDGSFRRGSMFDGSFRQSMRDRLILQSRGYSNVNDDDKTSVRCCSYSYFSDKITGVVKKLKDVLVTAWEMGTADPRKMIFSAKMGLALTLTSILIFFKIPGLELSGHYLWAILTVVVIFEFSIGATFSKGCNRGLGTLSAGGLALGMSWISEMTGNWADVFNAASIFVVAFFATYAKLYPTMKPYEYGFRVFLLTYCYVIVSGYKTGEFMETAVSRFLLIALGASVGLIVNTCIYPIWAGEDLHNLVAKNFVNVATSLEGCVNGYLECVAYDTIPSRILVYEAVAEDPVYSGYRSAVQSTSQEDTLMSFASWEPPHGPYKSFRYPWALYVKVGGALRHCAIMVMALHGCILSEIQAAEDRRREFRNELQRVGIEGAKVLRYIGESLKKMEKLNPIEDILYEIHQAAEELQSKIDKKSYLLVNAKNWEIGNRPRVRDLTDEQKISNLDSDLSRILAHKSQSEATLRPPKNWDDVTTAANLSSATMLPYLQSRTMIHKQPSWPSRISITPGSMLQPPLGEPGKMYESASNLSLATFASLLIEFVARLENLVNAYDELSVKANFKEAVSE
Protein: Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1) (Q03173)
Organism: Mus musculus (Mouse)
Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10069337, ECO:0000269|PubMed:12134088, ECO:0000269|PubMed:8861907}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Synapse {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity). {ECO:0000250}.
Interaction partners:
- Vasodilator-stimulated phosphoprotein
- Ena/VASP-like protein
- Profilin-1
- Profilin-2
- Zyxin
- Epithelial splicing regulatory protein 1
- Epithelial splicing regulatory protein 2
- Roundabout homolog 1
Sequence:
MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQEAAQSKVTATQDSTNLRCIFCGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERMERERLERERLERERLERERLEQEQLERQRQEREHVERLERERLERLERERQERERERLEQLEREQVEWERERRMSNAAPSSDSSLSSAPLPEYSSCQPPSAPPPSYAKVISAPVSDATPDYAVVTALPPTSTPPTPPLRHAATRFATSLGSAFHPVLPHYATVPRPLNKNSRPSSPVNTPSSQPPAAKSCAWPTSNFSPLPPSPPIMISSPPGKATGPRPVLPVCVSSPVPQMPPSPTAPNGSLDSVTYPVSPPPTSGPAAPPPPPPPPPPPPPPPLPPPPLPPLASLSHCGSQASPPPGTPLASTPSSKPSVLPSPSAGAPASAETPLNPELGDSSASEPGLQAASQPAESPTPQGLVLGPPAPPPPPPLPSGPAYASALPPPPGPPPPPPLPSTGPPPPPPPPPPLPNQAPPPPPPPPAPPLPASGIFSGSTSEDNRPLTGLAAAIAGAKLRKVSRVEDGSFPGGGNTGSVSLASSKADAGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDRNEDAEPITAKAPSTSTPEPTRKPWERTNTMNGSKSPVISRPKSTPSSQPSANGVQTEGLDYDRLKQDILDEMRKELAKLKEELIDAIRQELSKSNTA
Protein: FUN14 domain-containing protein 1 (Q6DH87)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- GABA
- Serine/threonine-protein phosphatase PGAM5, mitochondrial
- GABA
- non-specific serine/threonine protein kinase
- Unc-51-like autophagy-activating kinase 1a.
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Uncharacterized protein LOC100000242
- Proto-oncogene tyrosine-protein kinase Src
- Casein kinase 2, alpha prime polypeptide a
- non-specific serine/threonine protein kinase
Sequence:
MADRGEDAESEDELYEVVNITDYARRHQWWSRVFGNSTGPIAEKYSVASQIMMGGVSGWCAGYLFQRVGKLVATAVGGGFLLLQIANHSGYVQVDWRKVEKDVNKAKKHLKKNAKKAAPELNTFIEDSTEFVKRNIVISGGFVGGFLLGLAS
Protein: Homeobox protein MSX-2 (Homeobox protein Hox-8-1) (Q03358)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
Subcellular location: Nucleus.
Interaction partners:
- Runt-related transcription factor 2
- Homeobox protein MSX-1
- Homeobox protein MSX-3
- Msx2-interacting protein
- Bone morphogenetic protein 4
- Homeobox protein DLX-5
- Melanoma-associated antigen D1
- Transcription factor Sp7
- Osteocalcin
Sequence:
MASPTKGGDLFSSDEEGPAVLAGPGPGPGGAEGSAEERRVKVSSLPFSVEALMSDKKPPKESPAVPPDCASAGAVLRPLLLPGHGVRDAHSPGPLVKPFETASVKSENSEDGAPWIQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS
Protein: TRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein) (Q96CG3)
Organism: Homo sapiens (Human)
Function: Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22566686, ECO:0000305|PubMed:26068852}. Note=Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation. {ECO:0000269|PubMed:26068852}.
Interaction partners:
- TNF receptor-associated factor 6
- Alpha-protein kinase 1
- Interleukin-1 receptor-associated kinase 1
- TNF receptor-associated factor 2
- TRAF family member-associated NF-kappa-B activator
Sequence:
MTSFEDADTEETVTCLQMTVYHPGQLQCGIFQSISFNREKLPSSEVVKFGRNSNICHYTFQDKQVSRVQFSLQLFKKFNSSVLSFEIKNMSKKTNLIVDSRELGYLNKMDLPYRCMVRFGEYQFLMEKEDGESLEFFETQFILSPRSLLQENNWPPHRPIPEYGTYSLCSSQSSSPTEMDENES
Protein: Ethylene-responsive transcription factor ERF037 (O80654)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ethylene-responsive transcription factor ERF116
- CBL-interacting serine/threonine-protein kinase 12
- BZIP protein
Sequence:
MTESSIISVKQSSPVPEEEDHHHHQQDSHRTNTKKRVRSDPGYRGVRMRTWGKWVSEIREPRKKSRIWLGTFSTPEMAARAHDAAALTIKGTSAVLNFPELATYLPRPASSSPRDVQAAAAVAAAMDFSPSSSSLVVSDPTTVIAPAETQLSSSSYSTCTSSSLSPSSEEAASTAEELSEIVELPSLETSYDESLSEFVYVDSAYPPSSPWYINNCYSFYYHSDENGISMAEPFDSSNFGPLFP
Protein: Desmethyl-deoxy-podophyllotoxin synthase (EC 1.14.14.-) (Cytochrome P450 family 71 subfamily BE polypeptide 54) (A0A0N9HT29)
Organism: Sinopodophyllum hexandrum (Himalayan may apple) (Podophyllum hexandrum)
Function: Cytochrome P450 involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family. Catalyzes the conversion of deoxypodophyllotoxin to desmethyl-deoxypodophyllotoxin.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEFLSFPLSSALLIILLFMLVKKAIQNKNSKLPPGPRKLPVIGSLHHLIGDGLPHHALRNLAKKHGPLMHLQLGENSTLVVSSSKMARAIMSTHDLMFANRTVQFATDILLYGGKGIGLAPYGDYWRQIRKICVLELLSAKRVQSFQTVREEEISNLIRSISAESSKVNFSEMITSLTNDIIARAAFGEKCKDKHAFLSLIEEGIQLAGGFDIAGLFPSLKLLHVITGKKRQLERVHNELDRILVDIIKENKEKRRASKLNEDKYEENLVDVLVRVQENTQLEVPLANDNLKAVILDIFVAGSETSSTTIEWAMSEMLKNPKVMKKAQAEVRRVFSGNKKINETEIQELSYLKLVLKETLRLHAPAPLLIPRECRESCEIDGYEIPKKTMVMVNAWAIGRDPENWSNGDRFEPERFDGISVDYKGTNFEYIPFGAGRRICPGMLFGMANVEVPLARLLYHFDWELPNGIKPEELDMDETFGTTVRRKNHLYLIPTVVHELERSTTKE
Protein: Brevinin-1E (P32412)
Organism: Pelophylax lessonae (Pool frog) (Rana lessonae)
Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MFTLKKSMLLLFFLGTINLSLCEEERDADEEERRDNPDESEVEVEKRFLPLLAGLAANFLPKIFCKITRKC
Protein: DNA repair protein RAD51 homolog (Q557E6)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364139}.
Interaction partners:
- DNA helicase
- SNF2-related domain-containing protein
- DNA 3'-5' helicase
- DNA repair protein RAD51 homolog 3
- AAA ATPase domain-containing protein
- Uncharacterized protein
- Replication protein A subunit
- Telomerase reverse transcriptase
Sequence:
MASRQRQEEEEVDIENEQQQEEEEEEEEEESYLSINKLEGNGINAADLKKLQEQGLNTVQAVAFTTKKTLTGIKGISEQKADKLLAEAKKLVFMGFRTATDINKARAEIIQITTGSKEFDSLLDGGIESGSITEIFGEFRTGKTQICHTLCVTCQLGYSQGGGEGRALYIDTEGTFRPERLLAIAERYNLNGEHVLDNVSYARAYNSDHQLELLVQASAMMSESRYALLIVDSATALYRTDYAGRGELADRQKHLARFLRTLQRLADEFGVAVVITNQVVASVDGAGGMFNPDPKKPIGGHIMAHSSTTRLSLRKGKGEMRICKIYDSPSLPESEKPFGIYSDGISDYKEQ