wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear factor 1 (O70187)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
Sequence:
MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPNSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSTSPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQSWYLG
Protein: Early transcribed membrane protein 2 (O96128)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKLSKILYFFAALLALNFIAPRDYNSMVEAKPAKKLTPAERKKRNQNIMIYSSIASAVALLIGGAVGLGIHLHKNNKGDNKKGTPGAKKNDNKAVNPSISSTMYRA
Protein: Nucleolar protein 12 (Q8SWS7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Ribosome biogenesis protein BRX1 homolog
- RRM domain-containing protein
- Probable rRNA-processing protein EBP2 homolog
- Putative rRNA methyltransferase
- Ribosome biogenesis protein BOP1 homolog
- Nucleolar GTP-binding protein 1
- Ribosome assembly factor mrt4
- Probable ATP-dependent RNA helicase pitchoune
- Probable ribosome biogenesis protein RLP24
- Ribosome biogenesis protein WDR12 homolog
Sequence:
MTRKKAPKKKTEVVFDNKKRIEFLSGFRKRKNERRSRAKADLERNLKNERKRIRQEVKDGFNHLKKSFEPLRELTEEDKAEEAEQQQEETYEDDEVQVKIVELTTNDLAAKRNMLGANTAEESEPEEQADQSEEDEADQANRIPGMDFDPNARKRKPKPEDEEEPKATKSNNSTLPDIKSKKDLDRLMKTKTLKKMHQSKLFKQKERLDKKNNQKKAKRDRNNTIKSVPKHQRKQLKYGKANQTKYRKGRMVNKKELRRKRNAD
Protein: 5' exonuclease Apollo (EC 3.5.2.6) (DNA cross-link repair 1B protein) (SNM1 homolog B) (Q8T3E0)
Organism: Caenorhabditis elegans
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- ATP-dependent DNA helicase II subunit 2
- Ku domain-containing protein
- Protection of telomeres homolog 1
- Germ cell nuclear acidic-1 protein
Sequence:
MSTMLERRVSVASKFQDDRYYMVFHAYFDVLAQVHSVVETKNGSWTLRVWRAQKFGPEASKEKREMNLFHVTENTFKCYIVPPDPRIGKAVEESGKEFLIEIDVYDDHRIGIEKLNSGDFVALQNVHAASVGLTEMQVLHGGGQAYNRGISKVPVDFRNEAFQIFKKRVESVLEAVTDCDNFIEFQQKENVVQSETSTQTSSSNTSGDADLKHCQQIKIGEDISVDYFLKKSGSRYNFLTHAHSDHYRGLDKKWTRSVYCSPETAKLLPHIMGYTADSPPPAGLINPLEENVPHKFDSFQVTLVNANHCPGAVMFVFEGSKIEEIAGGAVLCTGDFRADKMFLESLKPGNQLHWMTEIKFGIIYLDNTYFSLDMPFPERCEAEKILLKAIEAHPHENIVIPLHRLGREELIQAISRILNEPIMVYDERKVISDLLDFSSNCGVLKQYRDIKVIKKGSYCEISQNSVIIDISMLYYTFGNGVNDDEGIIRIPYSDHSSRSEILKFLSHFHFKTITPCTKKYSIIELASLENAGKRSEEDHTVEKTQSTIQGTPISQLQEDPLPPGVVFRTNTCDFMDMDLDNWPEGPPKTFAEAIARANNSRRPRNPGL
Protein: Zygote-specific protein 3 (Q8GSP8)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: May have a role in the remodeling of the endoplasmic reticulum upon zygote formation.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:10069826}.
Interaction partners:
Sequence:
MLRSAGRVAAVALLALFALGCVSAAAKPSTDRLVAAIKSKNLSAVVDALSVKGLDVNTPDSTRRLPLVEAARSRDARLVGALLDQGALARVSDGTTTPLHLSMQGGSAAIVKLLLAHGADPNAKDKTGASARSTAAAVKELADLLKQWDARGAMAFEDEPGAWIREERDGQSYYWKPANGESRWAVPPSCAWQRVTVQGHPIKYINSLTGQETTRVPPALAWARVTAADGSALWLNWASRVASAAATAPAELPAELAAELAMHPNRRWYNTATREYVYTDPAYATPWRELVDEASGAPFFFNVETGDTTWELPAALAWTEVIESSSGADGESGSGSEAGPRYFHNTVSGEVAWSAPEGSRHVFVEASAADL
Protein: N-acetylglucosaminylphosphatidylinositol deacetylase (EC 3.5.1.89) (Q8I8A5)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MHGALAFGFVVVFLSFLVLWQRASCVSKIHLVGDVLFVFAHPDDEAMFFSPLLDYVRRHGLNAHFLCLSNGNYSGLGTVREKELVASAEYFGVNRRSVRVVDHPDLQDGPDNLWNTEIVQREVLSYLHSVKDIRTVITFDHRGVSSHANHVAVYEGVLLAKKNLPPGILFLSLHTRDLLEKYVGILSTVGYTVGIHRCGGRRNHVILIPPTSLFTSFSAMRKHKTQLVWFRYLFVWFSSYSYVNEVKELGVA
Protein: Angiotensin-converting enzyme (EC 3.4.-.-) (E2DHI3)
Organism: Rhinolophus macrotis (Big-eared horseshoe bat)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|PROSITE-ProRule:PRU01354}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|PROSITE-ProRule:PRU01354}. Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSGSFWLLLSLVAVTAAQSTTEDEAKKFLDKFNSKAEDLSYESSLASWDYNTNISDENVQKMDEAGAKWSAFYEEQSKLAKNYPLEEIQNDTVKRQLQILQQSGSPVLSEDKSKRLNSILNAMSTIYSTGKVCKPNNPQECLLLEPGLDNIMGTSKDYNERLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARGYHYEDYGDYWRRDYETEESSGPGYSRDQLMKDVDRIFTEIKPLYEHLHAYVRAKLMDTYPLHISPTGCLPAHLLGDMWGRFWTNLYPLTVPFGQKPNIDVTDAMLNQGWDANRIFKEAEKFFVSVSLPKMTEGFWNKSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMEDFLTAHHEMGHIQYDMAYASQPYLLRNGANEGFHEAVGEVMSLSVATPKHLKTMGLLSPDFREDDETEINFLLKQALNIVGTLPFTYMLEKWRWMVFKGEIPKEEWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTRTIFEFQFHEALCRIAQHNGPLHKCDISNSTDAGKKLHQMLSVGKSQAWTKTLEDIVDSRNMDVGPLLRYFKPLYTWLQEQNRKSYVGWNTDWSPYADQSIKVWISLKSALGEKAYEWNDNEMYLFRSSVAYAMREYFLKTKNQTILFGDENVWVSNLKPRISFNFHVTSPGNVSDIIPRPEVEGAIRMSRSRINDAFRLDDNSLEFLGIQPTLGPPYQPPVTIWLIVFGVVMAVVVVGIVVLIITGIRDRRKTDQARSEENPYPSVDLSKGENNPGFQNGDDVQTSF
Protein: Constitutive coactivator of peroxisome proliferator-activated receptor gamma (Constitutive coactivator of PPAR-gamma) (Constitutive coactivator of PPARG) (PPARG constitutive coactivator 1) (PGCC1) (Protein FAM120B) (Q96EK7)
Organism: Homo sapiens (Human)
Function: Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma
- DNA excision repair protein ERCC-5
- E3 ubiquitin-protein ligase UBR1
- DNA excision repair protein ERCC-5
- Retinoic acid receptor RXR-alpha
Sequence:
MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIKSHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDTDYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFESFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGEIECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRHPDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQALCCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGLTTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNLKAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQGQPWRDQGPGSRQYEHDQWRRY
Protein: Protein ROOT HAIR DEFECTIVE 3 homolog 2 (EC 3.6.5.-) (Protein SEY1 homolog 3) (Q9FKE9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable GTP-binding protein that may be involved in cell development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03109}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03109}.
Interaction partners:
- DNAJ heat shock N-terminal domain-containing protein
- Peptidyl-prolyl cis-trans isomerase FKBP20-1
- Ergosterol biosynthetic protein 28
- Probable pectin methylesterase CGR2
- Glycine-rich domain-containing protein 1
- Ultraviolet-B receptor UVR8
- Probable cyclic nucleotide-gated ion channel 10
Sequence:
MGENDDGCSTQLIDGNGEFNVKGLDNFVKKTKLSDCGLSYAVVAIMGPQSSGKSTLLNHLFKTSFREMDAFAGRSQTTKGIWMARCVGIEPFTIAMDLEGTDGRERGEDDTTFEKQSALFAIAVADIVLINMWCHDIGREQAANKPLLKTVFQVMLRLFSPRKTTLLFVIRDKTKTPIELLERALREDIQKIWDSVRKPEAHKNTPLNEFFNVMIVALSSYEEKEKQFEQEVAELRQRFFHSISPGGLAGDRRGVVPASGFSFSSQQIWKVIKENRDLDLPAHKVMVATVRCEEIANEKLRDLATNESWLELHEAAEGGLVPGFGKKLSSILEKYFSEYDAEAIYFDEGVRKEKRLQLKLNALDFVYPSYATMLGHLRSNALESFKIRLEQSLNQGEGFAKAVRDSQQSCLMVFDKGCEDAAVKQATWDASKIREKLCRDIDAHTFFARSAKLSELTANYEKRLTQALSEPVESLFEAGGKETWPSIRKLLKRETETAVTDFLDVVTGFELDHAKIDAMVQNLKNYSQSLVEKKAREEAAKILIRMKDRFSTVFSHDKDSMPRVWTGKEDIRAITKDARAEALSLLSVMTAIRLDERPDNIESTLFSSLMDGTVSAASSHNRSVGTSTDPLASSSWEEVPPNNILLTPVQCKSLWRQFKSETEYTVTQAISAQEAHKRNNNWLPPAWAIVLMIVLGFNEFMMLLKNPLYLLGFFVAFLLSKALWVQLDIPREFQHGAVAGVLSITSKFLPTVMNLLRKLAEEAQGKTTQEVPDLSASQTYRQQSPSHSISSTISESVASNISSAGDDAEYSSPSPALVRRRNTNNVQESEISQM
Protein: Remodeling and spacing factor 1 (H0YER1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
ATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQK
Protein: Syntaxin-17 (P56962)
Organism: Homo sapiens (Human)
Function: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23006999}; Multi-pass membrane protein {ECO:0000255}. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:23006999}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:26416964, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:29420192}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z158}. Mitochondrion membrane {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:28504273}; Multi-pass membrane protein {ECO:0000255}. Note=Has a hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (PubMed:23217709). {ECO:0000269|PubMed:23217709}.
Interaction partners:
- Vesicle-associated membrane protein 7
- Vam6/Vps39-like protein
- Synaptosomal-associated protein 29
- Vesicle-associated membrane protein 8
- Beclin 1-associated autophagy-related key regulator
- Vacuolar protein sorting-associated protein 41 homolog
- Synaptobrevin homolog YKT6
- Syntaxin-6
- Gamma-aminobutyric acid receptor-associated protein
- Synaptosomal-associated protein 23
Sequence:
MSEDEEKVKLRRLEPAIQKFIKIVIPTDLERLRKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNIREIEKLCLKVRKDDLVLLKRMIDPVKEEASAATAEFLQLHLESVEELKKQFNDEETLLQPPLTRSMTVGGAFHTTEAEASSQSLTQIYALPEIPQDQNAAESWETLEADLIELSQLVTDFSLLVNSQQEKIDSIADHVNSAAVNVEEGTKNLGKAAKYKLAALPVAGALIGGMVGGPIGLLAGFKVAGIAAALGGGVLGFTGGKLIQRKKQKMMEKLTSSCPDLPSQTDKKCS
Protein: Malate dehydrogenase (EC 1.1.1.37) (G3XAL0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
Protein: Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (RING-type E3 ubiquitin transferase NOSIP) (M0R1K2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPDDVQPGPSVGPPNSSVDRVGLITRSERYVCAVTRDSL
Protein: GATA zinc finger domain-containing protein 2 (Communication mutant protein H) (Q54V32)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MVKNSEHLPWYLGSDSATAASTATDATSADGAASETDAASATDTTSATDPTSATDPIATTNTTGITSSGPTTNGRRGRPYISTPPNRCYDCGRTRSPYWRKGTYNGQVVHLCNACGLNHIKIAKKSSAIFL
Protein: UDP-N-acetyl-D-mannosamine dehydrogenase (EC 1.1.1.336) (UDP-ManNAc 6-dehydrogenase) (Q6LZC3)
Organism: Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL)
Function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA). Cannot use NADP instead of NAD.
Interaction partners:
- UDP-N-acetylglucosamine 2-epimerase
- UDP-N-acetylglucosamine 2-epimerase homolog
- Na+/H+ exchanger
- Bifunctional protein GlmU
Sequence:
MEKHGDYDIKKICVIGLGYIGLPTASMLANHGYDVVGVDVNEKRVNQIKNGELKIEEPGLLTLVKGAINSKNLNVRTSATEADAFIICVPTPALAKEDGSKKCDLSYVMSAVEAILPFVKDGNLIVIESTIPPETTKKIYETLNKKIYVAHCPERVLPGKILKELVENDRIIGGINKKSAEMAKEIYKSFVEGQIYTTDSNTAEMVKLMENTYRDINIALANEFAKICDEIGVNVWDAIKIANKHPRVNILNPGPGVGGHCISIDPWFIVEKTNNAKFIRAARELNDNMPAYVCNSVLSELKKLGIEKPKISIFGATYKGNVEDTRESPSKNVIKMLLENGATVSTYDPHASYFEYPLSTLDECISGSDCIVVLTDHDVFKTIKKDDIDEICPKLKNKIVFDTKNILEHSLWKKAGFTVKLLGNGAW
Protein: Calsyntenin-1 [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)] (Q6Q0N0)
Organism: Rattus norvegicus (Rat)
Function: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:11161476}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O94985}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O94985}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000250|UniProtKB:O94985}. Note=Localized in the postsynaptic membrane of both excitatory and inhibitory synapses. {ECO:0000250|UniProtKB:Q9EPL2}.; SUBCELLULAR LOCATION: [Soluble Alc-alpha]: Nucleus {ECO:0000250|UniProtKB:O94985}. Note=The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000250|UniProtKB:O94985}.
Interaction partners:
- Kinesin light chain
- Kinesin light chain 1
- Kinesin light chain 4
- Kinesin light chain 3
- Amyloid-beta A4 precursor protein-binding family A member 2
- Amyloid-beta precursor protein
Sequence:
MLRRPAPALARAVRLLLAGLLYGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDSPLRFAGEICGFKIHGQNVPFDAVVVDKSTGEGIIRSKEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAPVFKEKSYKAAVVEGKQHGSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPGTGALAVFPSIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSSFNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLLRQDPSEEKKYRPAEFHWKLNQVCDEDWHHFVLNVEVPSVTLYVDGVSHEPFSVTEDYPLHPTKIETQLVVGACWQGGDLHMTQFFRGNLAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDGNRGVQIQTSSSQAVLTLEGENVGELDKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAACIEVPPVEGYVMVLQPEEPKISLSGVHHFARAASEFESPEGVSLFPELKIISTITREVEPEADGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNAEQESLEVDVARLQQKGIEVNHSDLGVVFTGVETMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTANPVEHANHMAAQPQFVHPEHRSFVDLSGHNLASPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEEDITSAESESSEEEEGGPGDGQNTTRQQQLEWDYSTLSY
Protein: Elongation factor 2 (C0HAQ6)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Elongation factor 1-gamma
- 40S ribosomal protein S30
- Ubiquitin-like protein FUBI isoform X1
- 40S ribosomal protein S15
- 60S acidic ribosomal protein P0
- 60S acidic ribosomal protein P0
- 60S ribosomal protein L18
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL12m
- 60S ribosomal protein L4-A
Sequence:
MVNFTVDQIRAIMDKKSNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGSRAGETRFTDTRKDEQERCITIKSTAISMYYELGENDMAFIKQTKDGLGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEDLFQTFQRIVENVNVIIATYGEDEAGPMGAIMIDPVIGTVGFGSGLHGWAFTLKQFAEMYVAKFSAGKDTQLGPAERCKKVEDMMKKLWGERFFDPATGKFSKTATGPDGKKLPRTFSQLVLDPIFKVFDAVMNFKKEETAKLIEKLDIKLDTEDKEKEGKPLLKAVMRRWLPAGEALLQMITIHLPSPVTAQKYRCELLYEGPGDDEAAMGIKNCDPKAPLMMYISKMVPTTDKGRFYAFGRVFSGCVSTGLKVRIMGPNFTPGKKEDLYIKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQYLIKTGTITTFEQAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHAGIPLKKSDPVVSYRETVSEESEVMCLSKSPNKHNRLYMRAKPFPDGLAEDIEKGDVSPRQELKIRARFLADKYEWDVSEARKIWCFGPDGTGPNLLMDVTKGVQYLNEIKDSVVAGFQWAVKEGVLCEENMRAIRFDIHDVTLHTDAIHRGGGQIIPTARRVLYACQLTAQPRLMEPVYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVMGTPMFIVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILQGDPQDPTTKTAIVVAETRKRKGLKEGIPALDNYLDKL
Protein: Transcription factor Sox-1a (Q6DGL6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional activator.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- Urotensin-related peptide 1.
Sequence:
MYSMMMETDLHSPGPQTNTNPGQTGPNSGSKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLGGAGGGVGMSPAGVGQRLESPGGHGGSASAGYAHMNGWANGTYSGQVAAAAAAAAMMQEAQLAYSQHPGSGSHHHHAHHHHPHNPQPMHRYDMTALQYSPISNSQSYMSASPSGYGGISYTQHQNSSVATSAAIGTLSSLVKSEPNISPPVTTHSRGPCPGDLREMISMYLPTGESGDPSVQSRLHALPQHYQSTTAGVNGTVPLTHI
Protein: Sec-independent protein translocase protein TATB, chloroplastic (Protein HIGH CHLOROPHYLL FLUORESCENCE 106) (Protein TWIN-ARGININE TRANSLOCATION B) (Q9XH75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation (By similarity).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=The C-terminus is located in the stroma. {ECO:0000250}.
Interaction partners:
- Sec-independent protein translocase protein TATA, chloroplastic
- Sec-independent protein translocase protein TATC, chloroplastic
- Protein THYLAKOID FORMATION 1
- Preprotein translocase subunit SCY1, chloroplastic
- Inner membrane protein ALBINO3
- Cell division protein FtsY homolog, chloroplastic
- Signal recognition particle subunit SRP54, chloroplastic
- Signal recognition particle 43 kDa protein, chloroplastic
- Mitochondrial inner membrane protein OXA1
- Expressed protein
Sequence:
MAMALQIIASSSSSPTITKSHLFSYPPLQSRYKASKPNLSSWFSLLGSSRFSPYIGLKHLGISISPKSSNPEKKRRCKSMMIRASLFGVGAPEALVIGVVALLVFGPKGLAEVARNLGKTLRTFQPTIRELQDVSRDFKSTLEREIGLDDISTPNVYNQNRTNPVQPPPPPPPPSVPSTEAPVTANDPNDSQSPKAYTSEDYLKFTEEQLKALSPAESQTEDQTQTQEPPQPTTVQTPTGESQPNGTARETTAASPPRQD
Protein: RH39293p (Q7YU72)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDAGYSPRKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEMPMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQNQLKKEELLKLAKIKEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDVSGPLGPNVKEKSMMFEQALRLRRDVPTKLLSRPVNYYEAAPRKIVNQTRLW
Protein: Regulator of V-ATPase in vacuolar membrane protein 1 (RAVE complex subunit rav1) (Q9Y817)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the RAVE complex which is required for stable assembly of the vacuolar ATPase complex V-ATPase.
Subcellular location: Cytoplasm. Nucleus. Endomembrane system {ECO:0000250}.
Interaction partners:
- Regulator of V-ATPase in vacuolar membrane protein 2
- Suppressor of kinetochore protein 1
- V-type proton ATPase subunit B
- V-type proton ATPase subunit E
- Vacuolar ATPase assembly integral membrane protein vph2
- Uncharacterized protein C2C4.05
- V-type proton ATPase subunit C
- Leptomycin B resistance protein pmd1
Sequence:
MPLAFTNPGTPLKRTAAYDNVQWNQNRILTFGTRYTVLIIVNNYESYQNIQFGESIGAVALDQRTGFLAIAHGQVLDIYKPADSLKWTHHYNYITQLSEDITQLSWGYNFDLLLCASSYTKLINFSEDKPRLVWSQNRISDSFLSSTISSDACFIASIETKNPLAKVWQRTSPQGTVSSCDDFSYLVHPCRVRFSQWSKHLHPDASGSTPFLSTVGYDNVLRIWQVGSRFGSQLMHLSCFLNLRKYYKSDQPPYCCFIDKDDFTIALAHAISRHSGQVHKDRILNRLLALASGQPHIFLLFTFECLYIFSLVIDQETLSSFELINQVPTNFPKGALQPDGFIPIYRTSKHEFYDYNIILFFQNSAREYMFSLTDFFYSDFELRVSYDFYGHDYPIKSLTRTSNGHGIVSRDVNRICMFQSYISQDGKNQLICRFRLLLGESDFILPLYAGEYAAVLNLNSLKLWHCNEAIPPTLLCTCRQVPTSPIITFFILPVQNNDNSALCALTEGGHAWFWSVSNEAHDGSAVLRFIDRVNFTKNLNIASAVDVMGWSSTLNLSSLSSFDQEVFQSISKDGLLQTWMARVLGDDKAEISEISKVQTSIKSATMIKGSTSKKVAVVSENNRRLSIFDTRSSEFSEKEEFSSVFDDYGPINDLDWTSTPNSHSILAVGFLHDVILLCQNRRSYMNDIPCWSRIRRYNLLEYTNSLISDSSWLDNGTLVTAIGNGLFYFDNSLPEDQSLLFPASLKRSAKNIFDLAYQLNGILPVFHPQLLQQLLLRNQPFLFTNILLRFYLCLKDDVDMHFLLNMDCSEFYCCDEEISKDLLIKSLSQNSAEILNPAELDFEETSVSKHLGLYIDEMIKKLTALLKVKKVKTLTRSSQFLLLNLIEAFNKARALRDSLDLNGKRYCIMLNQYVLSKHQRQLTSLPTREMAWAFHSSNKAVLLDHTKKLHGKPLLWNAVEEYAIPFWLNEQLLKDVFLELSRNHYAEIDDRNPENVSLYHIALHKINVFRDLWRLASWHKESARTVKLLSNDFSKKKWKVVASKNAFALLSKHRYFYASAFFLLADSCYDAAKVCIRNLKSISLAIAMTRVYEGDDGPTLKRLINEYVLPLAVSQNDRWLTNWSFTILKQEKKALQSLVSPIRSLVSDNDFIQLYTSDKNDQEIHENKDSQRNSTNEPVRNKFPSDDPAFILLYECLRSSNVQIDESLEYRFVLHNANVYCQLGCDLIALGLLRNWKFQKNPATAHLETEDYMVTDKQSAVEKTHDSPKLGKTLMGQDIRPTPDDVPEFNESAFSFE