wanglab/gogpt-training-data huggingface dataset:
Protein: threonine synthase (EC 4.2.3.1) (A0A1D8PNG9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Homoserine kinase
- Homoserine dehydrogenase
- Aspartokinase
- Threonine dehydratase
- Phosphoserine aminotransferase
- Aspartate-semialdehyde dehydrogenase
- Prephenate dehydrogenase [NADP
- L-serine ammonia-lyase
- L-serine ammonia-lyase
- low-specificity L-threonine aldolase
Sequence:
MPSSSQVYRSTRSSQPEELSFEDVVMTGLAPDGGLYLPSAIPQLPKDFLSKWTDLSFNELAFEILRLYINENEIPNADLKDLITRSYSTFRSSEVTPLKKLDDNLYILELFHGPTYAFKDVALQFVGNLFEYFLTRRNAQKDLTKQPRDIITVVGATSGDTGSAAIYGLRGKKDVSVFILYPTGRISPIQEEQMTTVEDENVHTLSVNGTFDDCQDIVKSVFGDKEFNDKYHVGAVNSINWARILAQQTYYFYSYFQLQKQAKTTNKVRFVVPSGNFGDILAGYYAYRMGLPVDKLIIATNENDILDRFIKSGEYAKEQEVGVKATYSPAMDILISSNFERLLWYLIRDNAPEVNKSDEKAGQLLNDWMKQLKEQGKFKVPAEVIDAARQVFDSQRVDNDTTVQTIKQVYDKSADKYVIDPHTAVGVTTSYSFIAKDTEPTQYISLSTAHPAKFSEVVNKALDSFDGYSFDKDVLPAELKALSSKEKRIKLIDEASVEKVKQAIKDELKF
Protein: Methane monooxygenase component A beta chain (EC 1.14.13.25) (Methane hydroxylase) (P18798)
Organism: Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Function: Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
Interaction partners:
- Methane monooxygenase component A gamma chain
- Methane monooxygenase component A alpha chain
- Methane monooxygenase regulatory protein B
- Methane monooxygenase component C
- Methane monooxygenase component D
- Particulate methane monooxygenase alpha subunit
- Ammonia monooxygenase/methane monooxygenase, subunit C family protein
- Methane monooxygenase, C subunit
- Putative methanol dehydrogenase protein, large subunit
- Particulate methane monooxygenase beta subunit
Sequence:
MSMLGERRRGLTDPEMAAVILKALPEAPLDGNNKMGYFVTPRWKRLTEYEALTVYAQPNADWIAGGLDWGDWTQKFHGGRPSWGNETTELRTVDWFKHRDPLRRWHAPYVKDKAEEWRYTDRFLQGYSADGQIRAMNPTWRDEFINRYWGAFLFNEYGLFNAHSQGAREALSDVTRVSLAFWGFDKIDIAQMIQLERGFLAKIVPGFDESTAVPKAEWTNGEVYKSARLAVEGLWQEVFDWNESAFSVHAVYDALFGQFVRREFFQRLAPRFGDNLTPFFINQAQTYFQIAKQGVQDLYYNCLGDDPEFSDYNRTVMRNWTGKWLEPTIAALRDFMGLFAKLPAGTTDKEEITASLYRVVDDWIEDYASRIDFKADRDQIVKAVLAGLK
Protein: F-box domain-containing protein (Q580J6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIAEQQNQGKECPDEPGPSSSCSSATRHRFQDLPYDVLLRCAEFMSVREVLSLGTINCFFHAFTTSENIVLWRHFTERVYLQHPYTLRQTLFNDSLLRMYAAINSIPVPLSSARAGVSDEYDVLNTAAISSQVISQEKLYQWVTDRCEEVIQDLRLFADIVENADSRFALTGLLVALQAVKKRMWCTEVADLESVRDLLRATVVEEEHDQGWVVLQTIANRTIPRRFLTSFTARMQSDNIESLNGKYKLLKRCWQRAAAVAREYMQLREVLRVVLAVSEVADHPNAQQRYDSVWSALCGTTAMLNAEKRRRCSESGDLDEVGAVIPMSATDDALLRQIRNLDKVTIGDIVSYFFGYVNGKVQRKTFLAALFSMKHLAGAEGYESVPFW
Protein: GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) (Q19980)
Organism: Caenorhabditis elegans
Function: Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.
Interaction partners:
- Putative 6-pyruvoyl tetrahydrobiopterin synthase
- GTP cyclohydrolase 1 feedback regulatory protein
- Inosine triphosphate pyrophosphatase
- Molybdenum cofactor biosynthesis protein moc-5
- Sorbin and SH3 domain-containing protein 1 homolog
- GTP 3',8-cyclase
- Trifunctional purine biosynthetic protein adenosine-3
- Cytochrome Oxidase Assembly subunits
- Bis
- Aromatic-L-amino-acid decarboxylase
Sequence:
MSRIENESGFLSSDAASVGSEDDKVEMKKRNGTIPKEDHLKSMCNAYQSIIQHVGEDINRQGLLKTPERAAKAMMAFTKGYDDQLDELLNEAVFDEDHDEMVIVKDIEMFSLCEHHLVPFMGKVHIGYIPNKKVLGLSKLARIVEMFSRRLQVQERLTKQIATAMVQAVQPSGVAVVIEASHMCMVMRGVQKINASTTTSCMLGVFRDDPKTREEFLNLINKR
Protein: Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) (Q62767)
Organism: Rattus norvegicus (Rat)
Function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13115}.
Interaction partners:
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 8
- Mitogen-activated protein kinase 9
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 1
- mitogen-activated protein kinase
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 13
Sequence:
MVTMEELREMDCSVLKRLMNRDENGGTAGSSGGSHGALGLLSGGKCLLLDCRPFLAHSAGYIRGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSTNESLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLTTSCAAEAASPSGPLRERGKATPTPTSQFVFSFPVSVGVHAAPSNLPYLHSPITTSPSC
Protein: Probable purine permease 4 (AtPUP4) (Q9SY29)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- T-box transcription factor, putative
- Protein yippee-like
- Pentatricopeptide repeat-containing protein At3g26630
- Equilibrative nucleotide transporter 8
Sequence:
MSDGRVNADPQQEENMVKPPVKRSLTLLIVTYFFLFFGSIASSLLAKYYFVYGGSSRWVSTWVQSAGFPLLLILIYFPHYVLKTTTRRPFTRFTLRHLIFSVLIGLVLGFNNFLFSWGTSYLPVSTSSLLLSTQLVFTLILSRIIVKQKITFSNLNCVVLLTLSSVLLALDSSKDKPSGLTKTKYFIGYVSTIGAGLLFALYLPVTEKLYRTVYCYAMVMEVQLVMEFAATVFATIGMACEGGFKEMVKEANHVFTKGPTFYWTFAILANVVTWQLSFAATSGMVYLTSGITGGICMTALLAMNVIGGVVAYGDVFGGVKIVSTVLCIWGFSSYTYGMYMKMKKEEKEKGEYSGVKTTEDSGEMEVEMGNVKDDVAAADDRA
Protein: Mitogen-activated protein kinase 10 (AtMPK10) (MAP kinase 10) (EC 2.7.11.24) (Q9M1Z5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mitogen-activated protein kinase kinase 9
- Mitogen-activated protein kinase kinase 2
- Mitogen-activated protein kinase kinase 5
- Mitogen-activated protein kinase kinase 4
- Mitogen-activated protein kinase kinase 1
- Mitogen-activated protein kinase kinase 3
- Dual specificity protein phosphatase 1B
- Protein ETHYLENE INSENSITIVE 3
- 1-aminocyclopropane-1-carboxylate synthase 6
- Transcription factor MYC2
Sequence:
MEPTNDAETLETQGEVTTAIWPSSQILKTTIDIPGTLSHDGRYIQYNLFGHIFELPAKYKPPIRPIGRGACGIVCSAVDSETNEKVAIKKITQVFDNTIEAKRTLREIKLLRHFDHENIVAIRDVILPPQRDSFEDVYIVNELMEFDLYRTLKSDQELTKDHGMYFMYQILRGLKYIHSANVLHRDLKPSNLLLSTQCDLKICDFGLARATPESNLMTEYVVTRWYRAPELLLGSSDYTAAIDVWSVGCIFMEIMNREPLFPGKDQVNQLRLLLELIGTPSEEELGSLSEYAKRYIRQLPTLPRQSFTEKFPNVPPLAIDLVEKMLTFDPKQRISVKEALAHPYLSSFHDITDEPECSEPFNFDLDEHPFSEEQFRELIYCEALAFNPETSND
Protein: C-C motif chemokine 25b precursor (Chemokine (C-C motif) ligand 25b) (F1QBE9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Chemokine
- Chemokine
- C-C chemokine receptor type 9a
- Chemokine
- C-C motif chemokine 21
- Atypical chemokine receptor 4a
- Atypical chemokine receptor 4b
- Stromal cell-derived factor 1
- C-C motif chemokine
- Interleukin-8
Sequence:
METQSSTMKFQILALLLLLACMYPSIAQGYYENCCLKYVTGIKKNMRRNIMSYRVQLTDGGCNIPAVVFKMRLKKQLKPKSVCADPRSDWVQAIIKELDEKNKRAM
Protein: Zinc finger protein 567 (Q8N184)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mitogen-activated protein kinase kinase kinase 20
Sequence:
MAQGSVSFNDVTVDFTQEEWQHLDHAQKTLYMDVMLENYCHLISVGCHMTKPDVILKLERGEEPWTSFAGHTCLEENWKAEDFLVKFKEHQEKYSRSVVSINHKKLVKEKSKIYEKTFTLGKNPVNSKNLPPEYDTHGRILKNVSELIISNLNPARKRLSEYNGYGKSLLSTKQETTHPEVKSHNQSARAFSHNEVLMQYQKTETPAQSFGYNDCEKSFLQRGGLITHSRPYKGENPSVYNKKRRATNIEKKHTCNECGKSFCRKSVLILHQGIHSEEKPYQCHQCGNAFRRKSYLIDHQRTHTGEKPFVCNECGKSFRLKTALTDHQRTHTGEKSYECLQCRNAFRLKSHLIRHQRTHTGEKPYECNDCGKSFRQKTTLSLHQRIHTGEKPYICKECGKSFHQKANLTVHQRTHTGEKPYICNECGKSFSQKTTLALHEKTHNEEKPYICSECGKSFRQKTTLVAHQRTHTGEKSYECPHCGKAFRMKSYLIDHHRTHTGEKPYECNECGKSFSQKTNLNLHQRIHTGEKPYVCNECGKSFRQKATLTVHQKIHTGQKSYECPQCGKAFSRKSYLIHHQRTHTGEKPYKCSECGKCFRQKTNLIVHQRTHTGEKPYVCNECGKSFSYKRNLIVHQRTHKGENIEMQ
Protein: Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (Q6E5U7)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}.
Interaction partners:
- Fas-associated death domain
- Tumor necrosis factor ligand superfamily member 6
- Caspase-8
- Caspase-8-like isoform X1
- Caspase-8
- Death domain-associated protein 6
- Receptor-interacting serine/threonine-protein kinase 1 isoform X1
- Uncharacterized protein LOC108278075 isoform X2
- Caspase-8
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
Sequence:
MEGKRALALLCVLWSVFCVTECVRRDGTRRRRRETCADDGLYSSSSGLQCCRCPIGHHLVRDCTSNGTAPECDACERGSYLDHANALSKCEPCKTCGVNDNMIEEKRCTPASNAMCRCMDGYYCDKGAECKVCYPCSTCEFGIKVPCNLTSDAQCHEQGPNTTTASIIIPILIIAFIIIIIIIAAVVYLWKKKLFCFKPPEPLKTPEPLDLLIDKDLGEFLPKISEILGVRVILQVVRQQRLLSEGVIDNITVENPHDASERAYHLLKAWYEKHGKTGAYRTLRENLIAIGKRSKADEVRELIGERENNNVT
Protein: Type II iodothyronine deiodinase (EC 1.21.99.4) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase) (Q9IAX2)
Organism: Gallus gallus (Chicken)
Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92813}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q92813}.
Interaction partners:
- Lipid transferase CIDEA
- Type I iodothyronine deiodinase
- Glutaredoxin domain-containing protein.
- Methionine sulfoxide reductase B1
- Uncharacterized protein.
- Thyrotropin receptor
- Sep15_SelM domain-containing protein.
- Uncharacterized protein.
- Thyrotropin subunit beta
- Uncharacterized protein.
Sequence:
MGLLSADLLITLQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSARGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGGEAPNSSVIHIAKGNDGSNSSWKSVGGKCGTKCHLLDFANSERPLVVNFGSATUPPFTSQLSAFSKLVEEFSGVADFLLVYIDEAHPSDGWAAPGISPSSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANVAYGVSFERVCIVQRQKIAYLGGKGPFFYNLQEVRLWLEQNFSKRUNPLSTEDLSTDVSL
Protein: ATP-dependent DNA helicase pfh1 (EC 3.6.4.12) (DNA repair and recombination helicase pfh1) (PIF1 helicase homolog) (RRM3/PIF1 homolog 1) (Q9UUA2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Involved in the maintenance of mitochondrial (mtDNA). Required for both repair of mitochondrial DNA and recognition of a recombinogenic signal characterized by a 26-bp palindromic at sequence in the ery region of mitochondrial DNA. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. Required for the completion of S-phase.
Subcellular location: [Isoform Nuclear]: Nucleus, nucleolus {ECO:0000269|PubMed:12409464, ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:18725402}. Note=Mainly concentrated in the nucleolus, and occasionally redistributes to single nuclear foci outside the nucleolus, probably sites of DNA repair. {ECO:0000269|PubMed:18725402}.; SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:18725402}.
Interaction partners:
- DNA replication ATP-dependent helicase/nuclease dna2
- Replication factor A protein 1
- ATP-dependent DNA helicase srs2
- DNA repair and recombination protein rad22
- Exodeoxyribonuclease 1
- Telomere length regulation protein elg1
- Proliferating cell nuclear antigen
- DNA repair protein rhp51
- DNA polymerase alpha catalytic subunit
- Single-stranded DNA-binding protein rim1, mitochondrial
Sequence:
MFSCQSLYKFSHSFRKRIPVMFQRAQQKSSLLHTQNESSHQPSLNKLGGFSSASLNFNSSRSSTNDDQQTFSSQSDNLPSSPITLPAKRGRSAASLKQLDNTVGFDVSKPSLPVFENSGLGSKYSTEIANGVYIDENDFDDDLLLENDIDQKPIPWSSSPIEHTKLTKSMLSSEKRSKNHLSKIYEDHTSEKGASSVISSNITRQGIKRSRTLPWAVDPYRYGDPDPKRTSTSADISQHTVSNDSSNKLSNGRSSSLDSLAKKRMSKSKSTPQISKKFSVPLNSASKSPIGSSLFKTSDSRKKSVPSIFLSDEQKRILDMVVEQQHSIFFTGSAGTGKSVLLRKIIEVLKSKYRKQSDRVAVTASTGLAACNIGGVTLHSFAGVGLARESVDLLVSKIKKNKKCVNRWLRTRVLIIDEVSMVDAELMDKLEEVARVIRKDSKPFGGIQLVLTGDFFQLPPVPENGKESKFCFESQTWKSALDFTIGLTHVFRQKDEEFVKMLNELRLGKLSDESVRKFKVLNRTIEYEDGLLPTELFPTRYEVERSNDMRMQQINQNPVTFTAIDSGTVRDKEFRDRLLQGCMAPATLVLKVNAQVMLIKNIDDQLVNGSLGKVIGFIDDETYQMEKKDAEMQGRNAFEYDSLDISPFDLPDVKQKKYKLIAMRKASSTAIKWPLVRFKLPNGGERTIVVQRETWNIELPNGEVQASRSQIPLILAYAISIHKAQGQTLDRVKVDLGRVFEKGQAYVALSRATTQEGLQVLNFSPAKVMAHPKVVQFYKQLASVNGLPIRNENKAPVQMRGVKNK
Protein: Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) (Q62792)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity).
Subcellular location: Nucleus.
Interaction partners:
Sequence:
VEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALN
Protein: G patch domain and ankyrin repeat-containing protein 1 (G5 protein) (HLA-B-associated transcript 4) (Q61858)
Organism: Mus musculus (Mouse)
Interaction partners:
- Uncharacterized protein C6orf47 homolog
Sequence:
MVGSLACHILALPSLHFLVSLTGMSRPSFIEFTPAADSSDLWKDGQQQPQQEKAEPVLDGAAARAFYEALIADDSSSSKPQRAEPMRERKKKRRRVTREPAAAGVPRQGRALEDEDRMAQWILLAAQNGDLTELRRLLEPQEAGGAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWVGVCDLGGRDAAQLAEEAGFPEVARMVRESHGETRSPENQNRSTPSSSQFCEDCGAHFEDSNHHTSTAHLLSLSRRPQPSNLPLGVPTSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTILKRDQEGLGYRSPPQPRVTHFAARDTRAVSGRERVPRVATLSQRENRRQEEKGRAWERDLRLYMNLEF
Protein: Acyl-protein thioesterase 1 (EC 3.1.2.-) (Palmitoyl-protein hydrolase) (EC 3.1.2.22) (O42881)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Glycerophosphocholine phosphodiesterase gde1
- Lysophospholipase NTE1
- Uncharacterized hydrolase C9G1.08c
- Probable CAAX prenyl protease 2
- NADPH--cytochrome P450 reductase
- Ras modification protein erf4
- Transport protein particle subunit trs31
Sequence:
MTAKLNSVIINPSVAHTATVIFLHGLGDSGQGWSFMANTWSNFKHIKWIFPNAPSIPVTVNNGMKMPAWYDIYSFADMKREDENGILRSAGQLHELIDAELALGIPSDRILIGGFSQGCMVSLYAGLTYPKRLAGIMGHSGFLPLASKFPSALSRVAKEIPILLTYMTEDPIVPSVLSSASAKYLINNLQLKCLDRPFEGDAHSLSSESFMAMYKFTQTVIGSP
Protein: Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Q6FRW1)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P78917}.
Interaction partners:
- Triosephosphate isomerase
- Transketolase
- Fructose-bisphosphate aldolase
- ATP-dependent 6-phosphofructokinase
- phosphoglucomutase
- Glucose-6-phosphate 1-dehydrogenase
- phosphoglucomutase
- ATP-dependent 6-phosphofructokinase
- Phosphoglycerate mutase
- Phosphoglycerate kinase
Sequence:
MASSNTYSNFKLATELPAWSKLQKLYDAQGKSLNVKEEFQKDSARYNKYAKTLTNYDGSKILFDFSKNLINDEILATLIELAKEAKVTDLRDAMFAGEHINFTEDRAVYHVALRNRANKPMKVDGVDVAPEVDAVLQHMKEFSEQVRSGEWKGYTGKKITDVVNIGIGGSDLGPVMVTEALKHYAGVLDVHFVSNIDGTHIAEVLKVVDPETTLFLVASKTFTTAETITNANTAKNWFLSKTGNDQSNIAKHFAALSTNETEVAKFGIDTKNMFGFENWVGGRYSVWSAIGLSVALYIGFDNFEAFLKGAEAVDKHFVETPLEDNIPLLGGLLSVWYNNFFGAQTHLVAPFDQYLHRFPAYLQQLSMESNGKSVTRGNVFSTYSTGSILFGEPATNAQHSFFQLVHQGTKLIPSDFILAAQSHNPIENNLHQKMLASNFFAQAEALMVGKDEAQVKSEGATGGLVPHKIFSGNRPTTSILAQKITPAALGSLIAYYEHVTFTEGAIWNINSFDQWGVELGKVLAKVIGKELDNTEKITAHDASTNGLINQFKEWL
Protein: Muscarinic acetylcholine receptor gar-3 (G-protein-linked acetylcholine receptor 3) (Q9U7D5)
Organism: Caenorhabditis elegans
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha
- Muscarinic acetylcholine receptor gar-2
- G-protein coupled receptors family 1 profile domain-containing protein
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-2
- Choline O-acetyltransferase
- G-protein coupled receptors family 1 profile domain-containing protein
- Acetylcholine receptor subunit alpha-type acr-16
- Gamma-aminobutyric acid type B receptor subunit 1
- Beta-arrestin arr-1
Sequence:
MQSSSLGNADDPRFRQTHLFQMLVKVINTSAENATKTAIATSSTSTPSFVDTYSTSSLLGEEGRMVMIVVIGAMFALVTSLGNLMVMVSFKIDKQLQTISNYFLFSLAVADIAIGVISIPMFTYYTAIQKWDLGYTMCQFWLCIDYLMSNASVLNLLLISFDRYFSVTRPLSYRPRRTTKKALTMIACTYIISLILWPPWIISWPYIEGKFTAEPGTCVVQFLQTNPYVTVGTAVAAFYLPVTIMCILYTRVYWETQKRQKEFGKLQATQTWASDVVDRPSTQSFRNSKMWKKVKKFSRRSMKRDVSSTSIIKSSGSMRKKNNQDGYVEDSVTPCTSSRNSKRKSWLRNCTGKSNSSSEDSSEAVAMNLDDTSLSSSHFALSGSRRRNISPPCTPMPTNFEDEEQTDAGASMRNGSARFRSRPSDTGKNNNSDTYTVLIELNDEGSRPSVRLSSCEPYLDEPISTRNRSKSDCNSEIDERRHSLLNKQSPFKNGRILKNFSSQERKSEKEQRKNERKQESKAAKTLSAILCAFIATWTPYNLIVCWEAFFPNTVPNVLWTFSYFLCYINSTINPLCYALCNARFRHTYMRILRCKFKAERPTMNQGYVRRN
Protein: Tara 1A isoform (Q9NHC2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKMWTESNVNSAMGLQATAATKRKHELTFDSKDANTTYTGNCAPPPVKANKWAISNNNYLESLEEQQQQQQSPSEPAVESNNNHIVLEASMDALKPTEPSISNGHEVTTAVAAMKSQAEVPLPPTASAAIPEDSIARLEVVTSAVPCEPWTSNGPTTPSAVAGPAASAEPVDCISKLQAVAVPSDPWGSIATRSTLATTLLSADELDDDDDDFEDDYEEEESIIPTYCPMRYHPFVPHPHPHSHQLPSHPHQQQPQQLSQQQPHPQQQQLAQQQQQHPQQQRSYAPGYGSRQPNYYSEPFPQQNCSRTGGPQHMTQSPPTPQQARGFAPPQWATAGSSPANPSSGAQQFYEPTNGGAYAPPAAPQQTIRCAENGKSYLDLGCSSGASGNAGGSPISPPPSSAPVVPFAGLPLHGLPLKRCCDGRPGGWCSTNRSCYKDTRLKIRNLSMFKLSRFRQVSEQSLYRSVLICNTLKRIDREIEAEAKELHQAAQQHHQQAAAAAAAAAAAAAQAAQYHPAYQQQQQQQQSPPAPLHPHTQQQMDYAPVLNCARLANMDHYQQLSFQPQHQQQQQPSQPHSYHERLDSQPAYRGAAAGAGSFATQPSNCDTSAGASSSNTSGNSNNSSATAASSNSSLHPYDHYPFRESQSGRATPFPACPTTTAAAAAASAAAAASSGGAATTLSSNISSSPASSSTSSNTTSSTVISSSSGNTVSSNGTTPVAPTASSSNCDTSDSGYADDDSTRSINWSSVLSLSSQSALDPLNNNDLFSILPSAATPTAVPVSVPASSSSSSSGSTLAFSGSFTTVQASGGSSSSCGSSSTTATFTTLSTISSATHSLTSSYVSSISSNVSAGANTWEYGFLDMEFGLGSEFTELVPSCKLSSEDLFKSGLGGQVVTASRLHDNELEHPAHIMVGS
Protein: Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) (P28370)
Organism: Homo sapiens (Human)
Function: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity. Acts as a negative regulator of chromatin remodelers by generating inactive complexes.
Subcellular location: Nucleus.
Interaction partners:
- Bromodomain adjacent to zinc finger domain protein 1A
- Nucleosome-remodeling factor subunit BPTF
- Chromatin remodeling regulator CECR2
- Tyrosine-protein kinase BAZ1B
- Histone-binding protein RBBP4
- DNA polymerase epsilon subunit 3
- Chromatin accessibility complex protein 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- BPTF-associated chromatin complex component 1
- Histone-binding protein RBBP7
Sequence:
MEQDTAAVAATVAAADATATIVVIEDEQPGPSTSQEEGAAAAATEATAATEKGEKKKEKNVSSFQLKLAAKAPKSEKEMDPEYEEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPRIKKDEKQSLISAGDYRHRRTEQEEDEELLSESRKTSNVCIRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESELTDEDITTILERGEKKTAEMNERLQKMGESSLRNFRMDIEQSLYKFEGEDYREKQKLGMVEWIEPPKRERKANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPDIPNPALAQREEQKKIDGAEPLTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGRDDIDNIAREVEGKSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEIEERERAEKKKRATKTPMVKFSAFS
Protein: Regulatory P domain-containing protein (Q5AWZ9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MKLSALSLLTVACVATASSHGAETMEYLMSLKQQSRERARSQGLFDINRYPDEGAKKCKNGKAGEYSCENVDLLSFLSHQALGSVTREGNDVWGWTSAEGREFGIVGQTDGVAFVEILEDGSLEYVGRLGSQTEPSTWRDIKVIGDHAYIGSEAAGHGLQIFDLNKLTTASSSKPTVFSTKKDLTAWYRGFGSSHNIVAHEETNMIYAVGTARNLSCAGGLWMVDVSDPANPTSPGCVNEDGYVHDAQCVIYKGPDEKYIGQEICFNFNEDTLTIADVTDKKNPIQISKTPYVGASYTHQGWLVDENDHSYLLLDDELDEMDGTGSAANGHTTTYIFDIKDLSAPKHTGTYQSPVRSIDHNQYVVAGLSYQSNYGSGLRVVDVSSVFEDPTASSFKEVGSFDVHPEDDAVGGEVEFVGSWSVYPFFASGHILLNSIERGIYSLKYTGPAAEN
Protein: Ceramide-binding protein SVF1 (Q05515)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for survival in response to oxidative stress. Involved in the diauxic shift.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:36897280}; Peripheral membrane protein {ECO:0000269|PubMed:36897280}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:36897280}; Peripheral membrane protein {ECO:0000269|PubMed:36897280}. Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:36897280}. Nucleus {ECO:0000269|PubMed:14562095}. Note=Localizes to the interface between the cis-Golgi network and endoplasmic reticulum exit sites. {ECO:0000269|PubMed:36897280}.
Interaction partners:
Sequence:
MLKWIKGGISAVTGMAEPEYGKDYIHSVADRVKNKQPYRETSREDFFWQAPDHTNVESVIFYFSDLKTGIFGFAQVIHSNIIGLHTASQFTFRIFDSKNPEDLNIWTSTKLENFYIEGPNFYADNLSVELSEDGESYHIQSSVCDLSVVDLHIRRLTPGAKIGDDPATYYGNNINEPWGSMRHVFWPRNACHGTIKVKKEVIPESDEEESSADEDDNEDEDEESGDSEEESGSEEESDSEEVEITYEDRTITFKEEDPAISTFIMAFQGMKPHHAAKAWNFMFFHSEKYSAVLMEFTTPKSYANTKISAGIITDDKEVLAMTTNNLVEHLNSEIDSVGWKVPKDIKITFKGINTKVKDEQLESENGTEQALQGEDEKEDEKEDEEEEEYKNVAEENKICAVVEGPLNNLVERIDVMGEIPSFVKNIVSGVAGTKPFIYQYADPKSSTLQINGGEKIHGVAWTEVTFISESDVISEESYNEA