wanglab/gogpt-training-data huggingface dataset:
Protein: SD03655p (Transmembrane endosomal protein, isoform A) (Transmembrane endosomal protein, isoform B) (Q960F6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSTTAASLIEAALNASSGNATATTAGSLEATGKPNYVVQVKNTPMSTPLDPLLHVGDGIFLQTKTAQVLAGVCVWAALFITCQQIYQHLRWYTNPQEQRWIVRILFIVPIYATYSWISLLFFNSDNVYIYFFTVRDCYEAFVIYNFLSLCYEYLGGEGNIMSEIRGKPIKTSCLYGTCCLKGKTYTIGFLRFCKQATLQFCLVKPLVAFIIIFLQAFGHYHDGDWSADGGYIYITIIYNISVSLALYGLYLFYFATRDLLTPFEPVLKFCTIKSVIFLSFWQGVGLAILEKANVISPIVDSAGTVTVEPGTVSAGYQNFFICIEMLFAAIALRYAFPYQVYARSCISDGHGRSVTMQSISSSLKETMNPKDIMTDAIHNFHPQYQQYTQYSSEVTSAQRYEKL
Protein: C4b-binding protein alpha chain (C4bp) (Q63514)
Organism: Rattus norvegicus (Rat)
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
Subcellular location: Secreted.
Interaction partners:
- Complement C4
- C4b-binding protein beta chain
- Complement C4A
- Complement C4A.
- Haptoglobin
- Kininogen-1
- Fibrinogen gamma chain
- Inter-alpha-trypsin inhibitor heavy chain 4
- Plasma protease C1 inhibitor
- Mannose-binding protein C
Sequence:
MSLTAALWVAVFGKCGPPPDLPYALPASEMNQTDFESHTTLRYNCRPGYSRASSSQSLYCKPLGKWQINIACVKKSCRNPGDLQNGKVEVKTDFLFGSQIEFSCSEGYILIGSSTSYCEIQGKGVSWSDPLPECVIAKCGMPPDISNGKHNGREEEFFTYRSSVTYKCDPDFTLLGNASITCTVVNKTVGVWSPSPPTCERIICPWPKVLHGTINSGFKHTYKYKDSVRFVCQKGFVLRGSGVIHCEADGSWSPVPVCELNSCTDIPDIPNAALITSPRPRKEDVYPVGTVLRYICRPGYEPATRQPMTVICQKDLSWSMLRGCKEICCPVPDPKSVRVIQHEKAHPDNDCTYFFGDEVSYTCQNDIMLTATCKSDGTWHPRTPSCHQSCDFPPAIAHGRYTKSSSYYVRTQVTYECEEGYRLVGEATISCWYSQWTPAAPQCKALCRKPEIGNGVLSTNKDQYVETENVTIQCDSGFVMLGSQSITCSENGTWYPKVSRCEQEVPKDCEHVFAGKKLMQCLPNSNDVKMALEVYKLTLEIKQLQLQIDKAKHVDREL
Protein: Ribonuclease P protein subunit p25 (RNase P protein subunit p25) (Q9BUL9)
Organism: Homo sapiens (Human)
Function: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12003489, ECO:0000269|PubMed:20215441}.
Interaction partners:
- Ribonuclease P protein subunit p38
- Ribonuclease P protein subunit p40
- Ribonuclease P/MRP protein subunit POP5
- Ribonuclease P protein subunit p20
- Ribonuclease P protein subunit p30
- Ribonuclease P protein subunit p29
- Ribonucleases P/MRP protein subunit POP1
- Ribonuclease P protein subunit p21
- Ribonuclease P protein subunit p14
- Mitochondrial ribonuclease P catalytic subunit
Sequence:
MENFRKVRSEEAPAGCGAEGGGPGSGPFADLAPGAVHMRVKEGSKIRNLMAFATASMAQPATRAIVFSGCGRATTKTVTCAEILKRRLAGLHQVTRLRYRSVREVWQSLPPGPTQGQTPGEPAASLSVLKNVPGLAILLSKDALDPRQPGYQPPNPHPGPSSPPAAPASKRSLGEPAAGEGSAKRSQPEPGVADEDQTA
Protein: Protein SOF1 (U3 small nucleolar RNA-associated protein SOF1) (U3 snoRNA-associated protein SOF1) (P33750)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for ribosomal RNA processing.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:8508778}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 13
- rRNA processing protein RCL1
- U3 small nucleolar RNA-associated protein MPP10
- Periodic tryptophan protein 2
- 13 kDa ribonucleoprotein-associated protein
- NET1-associated nuclear protein 1
- Ribosome biogenesis protein ENP2
- rRNA-processing protein FCF1
- KRR1 small subunit processome component
Sequence:
MKIKTIKRSADDYVPVKSTQESQMPRNLNPELHPFERAREYTKALNATKLERMFAKPFVGQLGYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKTTREKNKLEYDEKLKERFRHMPEIKRISRHRHVPQVIKKAQEIKNIELSSIKRREANERRTRKDMPYISERKKQIVGTVHKYEDSGRDRKRRKEDDKRDTQEK
Protein: DNA helicase (EC 3.6.4.12) (E9Q614)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASPLRDEEEEEEEMVVSEEEEEEEEEGDEEEEEVEAADEDDEEEDEEGVLGRGPGHDRSRDRHSPPSCHLFPPPPPPLPPPPPPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKLDSEEEFGSERDEYREKSESGGSEYGTGPGRKRRRKHREKKEKKTKRRKRGEGDGGHKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPPALPPPPAPEIQPPPIRRAKTKEGKGPGHKRRNKSPRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKAGSCAFQSEEGHEPEAEESDLDSGSVHSASGWPDGPVRAKKLKRGRPGRKKKKVLGCPAVTGEEEVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAKEEEEEYEEEGEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSYHIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAPQQADGNPDVPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDYGSGEDDGKSDKRKVKDPHYAEMEEKYYRFGIKPEWMTVHRIINHSMDKKGNYHYLVKWKDLPYDQSTWEEDEMNIPEYDDHKQSYWRHRELIMGEDPAQPRKYKKKKKELQGDGPPSSPTNDPTVKYETQPRFITATGGTLHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPKFYVVTYTGDKDSRAIIRENEFSFEDNAIKGGKKAFKMKREAQVKFHVLLTSYELITIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSPMQKKYYKYILTRNFEALNSRGGGNQVSLLNIMMDLKKCCNHPYLFPVAAMESPKLPSGAYEGGALIKSSGKLLLLQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDSSVIHYDNEAIARLLDRNQDATEDTDVQNMNEYLSSFKVAQYVVREEDKIEEIEREIIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDFDERPEGRRQSKRQLRNEKDKPLPPLLARVGGNIEVLGFNTRQRKAFLNAVMRWGMPPQDAFTTQWLVRDLRGKTEKEFKAYVSLFMRHLCEPGADGSETFADGVPREGLSRQQVLTRIGVMSLVKKKVQEFEHINGRWSMPELMPDPSAESKRSSRASSPTKTSPTTPEASTTNSPCTSKPATPAPSEKGDGVRTPLDKDDTENQEEKPEKNSKVGEKMEAEVDSPSPAPSLGERLEHRKILLEDEAPGVPGETEPEPGYRGDREKSEDVKADRELRLGPPRDEPRPNGRREEKVEKPRFMFNIADGGFTELHTLWQNEERAAISSGKLNEIWHRRHDYWLLAGIVLHGYARWQDIQNDAQFAIINEPFKTEANKGNFLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNLSQEPAHPAMALHARFAEAECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPATLSRIPPIAARLQMSERSILSRLASKGTEPHPTPAFPPGPYATPPGYGAAFSAAPVGALAAAGANYSQMPAGSFITATTNGPPVLVKKEKEMVGALVSDGLGLDRKEPRAGEVICIDD
Protein: Rho-associated protein kinase (EC 2.7.11.1) (A0A0R4IVY5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cell projection, bleb {ECO:0000256|ARBA:ARBA00043945}. Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395}.
Interaction partners:
- Rho-related GTP-binding protein RhoA-B
- Rho-related GTP-binding protein RhoA-A
- Rho-related GTP-binding protein RhoA-D
- Rho-related GTP-binding protein RhoA-C
- LIM domain kinase 2
- LIM domain kinase 1a.
- LIM domain kinase 1
- Mitogen-activated protein kinase
- Myosin regulatory light chain 2b
- Myosin regulatory light chain 2a
Sequence:
MEMSIGESLTARFEKIDAMLKDPKSEVNTDCLLDSLDALVYDLDFPALRKNKSIDDFLKRYKDTISKIRELRMKAEDYEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSNWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALTFPEDSDISKDAKSLICAFLTDREVRLGRNGVDEIKRHGFFKNDQWTWENIRETAAPVVPELSCDTDTSNFDDIEEDRGEEETFPIPKAFVGNQLPFVGFTYYSNNLFSQESTIKTSDKRSSTKEDKSLLENLQKRIYQLEEQVHSEMQLRDEMEQKCRASNTKLDKIMKELDEESNLRKSVEANMSILEKDKIMIQHRATEYQRKADQEAEKRRNLENEVSTLKEQLEDLRKISQNNDKIAQLQNQLGEANDLLRAESDTVMRLRKSHTEMGKTMSQLESINRELQEKIRAAESVKQQLEKELLQLQTTLDTERRSCSQGSEEIRELQVRIMGLQEDNKNLKQSLTKVETERKHVQERCNILEKEKNSLEIDLNYKLKTLQQRLDQELTEHRITKAQLTDKYESIEESKSAAMHAVEQKVSEETTLRMRAESRVVEVEKQCSMLEFDLKQSVQKMEQLMKQKERLEDEVKDLRVQLEQETGKRVMSQNELKNWKMDSERLKGTEKQLKQEINAALENKRSVEFQLAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKDEIEEKNRQTQEALKRVQDLNSEKESLSAQLDLTMTKAESEQLARALQEEQYVELSQEYKKAVSRYKQEISEKDSTISQLEDSNKTLTKDVEILSKEKTEFNERIQAQEQEFAAEREELTNSIKANYEKALNIERTLKTQAVNKLAEIMNRKDMKDQKKRGSTTDLRKKEKENRKLQLELNQEKEKFNHMAFKYQKELNEMQAQWAEECTYRNELQMQLDSKESDIEQLREKLNDLQLRVDNSSVTSLQPDELDSNIAESRLEGWLAIPNRANIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETDEIPRIFQILYANEGECRKETDVESVPQGDKANCLPHKGHEFIPTLYHFPTNCEACSKPLWHVFKPPPALECRRCHVKCHKDHLDKKEDMITPCKVNYDVTSARDMLLLALSQDEQKKWIGHLGKKIPKTPPSTFARQSPRSMSVRSGANQSFRKNPKNVPGKPS
Protein: Interleukin cytokine receptor-related protein 2 (Interleukin-17 receptor-like protein 2) (Q10128)
Organism: Caenorhabditis elegans
Function: Forms a receptor complex together with receptor ilcr-1, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downstream signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28099418}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Interleukin cytokine receptor-related protein 1
- Interleukin cytokine-related protein 17.1
- ACT1-like protein
- ANK repeat-containing protein nipk-1
- Small ribosomal subunit protein bS16m
- Interleukin-17
- Clip domain-containing protein
- Pelle-like serine/threonine-protein kinase pik-1
Sequence:
MVRLCTTNFLAYRATGSPLLLLYFYLCSLSSVKSSAAASYTNASDYVLRNVFEHSDQCYKDSFVYVRADDKKSDPFITYSTTKECSERLKKNDLPEKLPTCPPGLIDLELKPVYVPKSQISYPYANLNISVTAHSSVDTIAFRLECLSASDGSDVYCSNSKAMYINGVKEWPCRGIHLSSRVQYPTRFSYSCFRLTSFSVYAINATILPQKCRVSTIMTAPYFDDMFPEILVDPTTNQSIITKTDPFWAPMLSADFSDKNAIWVRLGKAERAECETMVVNVYKEHDDDSQKVTFLEILTVKCPETAVKWENQKAGRYLLTAYVPIRGCKFYCEKKERGCRQCLRTHLNLVIYKNRASLSWLALQKFKDYGFEIFIAVVVLLILIIVLAVTGFGYVLWRDKVRSREVRNIALTEFVKVMIVYADDNDLHTDCVKKLVENLRNCASCDPVFDLEKLITAEQIVPSRWLVDQISSLKKFIIVVSDCAEKILDTEASETHQLVQARPFADLFGPAMEMIIRDATHNFPEARKKYAVVRFNYSPHVPPNLAILNLPTFILPEQFAQLTAFLHNVEHTERANVTQNISEAQIHEWNLCASRMMSFFVRNPNWLETRWKPKDELAALHLKRQSPVIVPIQTEEDRIAASIKYNLVPPQALVDSDDEDDVDLQPHASHQNQPLILLPPEQCGPDSDSDSESDSSSESESESDNEGEDPKTIVVKKS
Protein: At4g26950 (Q9SZ34)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEKSYMKHELWGDGDFQEDDVWDVLDGYQSPFMISSNHTTKPSFSTQTLLPSEPRMIPERQRTEGMAPMRQQSVPVNVPDWSMVQRKKTKKVVDDENVSPEEYFLRRSRSSSSSSVMEGVGRKLKGRDLSKVRNAILKQTGFLE
Protein: High mobility group protein 1 (High spontaneous mutagenesis protein 2) (Q03973)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12374750, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:8969238}. Note=Colocalizes with FOB1.
Interaction partners:
- Small ribosomal subunit protein eS6A
- Protein IFH1
- U3 small nucleolar RNA-associated protein 22
- Small ribosomal subunit protein uS11A
- KRR1 small subunit processome component
- Small ribosomal subunit protein uS4A
- Small ribosomal subunit protein eS7A
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS11B
- DNA-directed RNA polymerase I subunit RPA49
Sequence:
MTTDPSVKLKSAKDSLVSSLFELSKAANQTASSIVDFYNAIGDDEEEKIEAFTTLTESLQTLTSGVNHLHGISSELVNPIDDDKDAIIAAPVKAVRRKIERDPNAPKKPLTVFFAYSAYVRQELREDRQKAGLPPLSSTEITQEISKKWKELSDNEKEKWKQAYNVELENYQREKSKYLEAKKNGTLPPASLENGPTHAPVPIPFSLQHAAEPPVEKRPHDDDGSSEKKKKKKKKDKKKDKSNSSI
Protein: Helix-loop-helix protein hlh-2 (G5EEG9)
Organism: Caenorhabditis elegans
Function: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Plays a key role in the anchor cell/ventral uterine precursor cell (AC/VU) decision; required for VU fate. Regulates expression of lin-12/Notch receptor and putative ligand lag-2 in the presumptive AC and presumptive VU cells. Modulates expression of lag-2 in the gonadal distal tip cells (DTCs). Involved in formation of the polarised cell membrane of the AC and thus facilitates invasion across the gonadal basement membrane, acting via transcriptional modulation of multiple genes. Involved in specification of the hermaphrodite DTC and the male linker cell, perhaps acting in concert with the homeobox protein, ceh-22. Plays a role in regulation of migration of DTCs and the modulation of expression of alpha integrin ina-1 and ADAMTS protease gon-1. Required for DTC maintenance, and for function of the DTC as a niche for germline stem cells. Plays a role in cell-autonomously establishing a neuronal left-right asymmetry. Required for specification of cell fate, acting in concert with lin-32, in the development of the male-specific genital sensilla (simple sense organs) known as rays. Negatively modulates lifespan, perhaps acting by regulating expression of arginine kinases, which in turn results in altered metabolism and homeostasis of reactive oxygen species (ROS).
Subcellular location: Nucleus {ECO:0000269|PubMed:11076762}.
Interaction partners:
- Helix-loop-helix protein 14
- Helix-loop-helix protein 15
- Myoblast determination protein 1 homolog
- Protein lin-32
- Helix-loop-helix protein 3
- Twist-related protein
- Helix-loop-helix protein ngn-1
- Hand transcription factor 1
- Helix-loop-helix protein 10
- Neurogenic differentiation factor 1
Sequence:
MADPNSQLTSATTVATAAIAQPQVMLPNAYDYPYNIDPTTIQMPDYWSGYHLNPYPPMQTTDIDYSSAFLPTHPPTETPASVAAPTSATSDIKPIHATSSTSTTAPSTAPAPTSTTDVLELKPTTAPATNSAETSAIVAPQPLTNLTAPIDAMSSMYTWPQTYPGYLPPSEDNKASEAVNPYISIPPTYTFGADPSVADFSSYQQQLAGQPNGLGGDTNLVDYNHQFPPAGMSPHFDPNGYPGMTGMPPGSSASSVRNDKSASRATSRRRVQGPPSSGIPTRHSSSSRLSDNESMSDDKDTDRRSQNNARERVRVRDINSAFKELGRMCTQHNQNTERNQTKLGILHNAVSVITQLEEQVRQRNMNPKVMAGMKRKPDDDKMKMLDDNAPSAQFGHPRF
Protein: 15-cis-phytoene desaturase, chloroplastic/chromoplastic (EC 1.3.5.5) (Phytoene dehydrogenase) (Phytoene desaturase) (A2XDA1)
Organism: Oryza sativa subsp. indica (Rice)
Function: Converts phytoene into zeta-carotene via the intermediary of phytofluene by the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene with a concomitant isomerization of two neighboring double bonds at the C9 and C9' positions from trans to cis. Active with decylplastoquinone (DPQ) as substrate. Also active with other benzoquinones, which are strongly preferred over naphthoquinones as substrates.
Subcellular location: Plastid, chloroplast {ECO:0000250|UniProtKB:Q40406}. Plastid, chromoplast {ECO:0000250|UniProtKB:Q40406}. Membrane {ECO:0000269|PubMed:26147209}; Peripheral membrane protein {ECO:0000269|PubMed:26147209}.
Interaction partners:
- 15-cis-phytoene synthase
- NnrU domain-containing protein
- 15-cis-phytoene synthase
- 15-cis-phytoene synthase
- Zeta-carotene desaturase
- Histone H4
- Uncharacterized protein
- High mobility group B protein 9
- Uncharacterized protein
- prolycopene isomerase
Sequence:
MDTGCLSSMNITGTSQARSFAGQLPTHRCFASSSIQALKSSQHVSFGVKSLVLRNKGKRFRRRLGALQVVCQDFPRPPLENTINFLEAGQLSSFFRNSEQPTKPLQVVIAGAGLAGLSTAKYLADAGHKPILLEARDVLGGKIAAWKDEDGDWYETGLHIFFGAYPNIQNLFGELGINDRLQWKEHSMIFAMPNKPGEFSRFDFPETLPAPLNGIWAILRNNEMLTWPEKVKFALGLLPAMVGGQAYVEAQDGFTVSEWMKKQGVPDRVNDEVFIAMSKALNFINPDELSMQCILIALNRFLQEKHGSKMAFLDGNPPERLCMPIVDHVRSLGGEVRLNSRIQKIELNPDGTVKHFALTDGTQITGDAYVFATPVDILKLLVPQEWKEISYFKKLEKLVGVPVINVHIWFDRKLKNTYDHLLFSRSSLLSVYADMSVTCKEYYDPNRSMLELVFAPAEEWVGRSDTEIIEATMQELAKLFPDEIAADQSKAKILKYHVVKTPRSVYKTIPDCEPCRPLQRSPIEGFYLAGDYTKQKYLASMEGAVLSGKLCAQSVVEDYKMLSRRSLKSLQSEVPVAS
Protein: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) (E7FDY7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSLPLSRSEVFGQLRKELHDDTAFHQSDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDAIRIACMPYMKVVDNEAERLAAFFSRNSYISGKYVEESSFSDLNTHLLSLPGGAEANRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRVIVEKPFGRDLQSSEELSSHLSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDVVLGQYVGDPDGEGEAKLGYLDDKTVPKGSTQATFATAVLYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETELDLTYHSRYRDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQKVGFRYEGTYKWVNPHKL
Protein: Phospholamban (PLB) (P61016)
Organism: Rattus norvegicus (Rat)
Function: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P26678}; Single-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P26678}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:A4IFH6}; Single-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:P61014}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with HAX1 at the endoplasmic reticulum. Colocalizes with DMPK at the sarcoplasmic reticulum. {ECO:0000250|UniProtKB:P26678}.
Interaction partners:
- Calcium-transporting ATPase
- cAMP-dependent protein kinase catalytic subunit alpha
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
- cAMP-dependent protein kinase catalytic subunit beta
- cGMP-dependent protein kinase 2
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Plasma membrane calcium-transporting ATPase 4
Sequence:
MEKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLILICLLLICIIVMLL
Protein: Uncharacterized protein (Q387V0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Rapamycin-insensitive companion of TOR2
- Raptor N-terminal CASPase-like domain-containing protein
- Raptor N-terminal CASPase-like domain-containing protein
- ethanolamine kinase
- Serine/threonine-protein kinase TOR
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase TOR
- non-specific serine/threonine protein kinase
- PI3K/PI4K catalytic domain-containing protein
- Ras-family member, GTP-binding protein, putative
Sequence:
MSSTFIISASYDKEIRFWDGSTGRTVRSFPFQGSQVNAMLTIPNTTHLAVGGFGAVRVYDIGVEAGSAGGNSGTQPPPVFSVYENQYAMNVTSLGTFPLYPQRDEEMHLNSAEASMSSLFCTSADLAATATLDPTPTTGSAGVLTVLFATSEDGHIRFFNANSPTTLNLLLDISAGAAITCSAVSPDRHTLFTGSQIGRVSVWHIPSIIAAAAQHGDSTSRGGLFASKPMQEIAFNGDYTAIRSIAVEPLARWAVAATSAGKLHFMCFGRCAQNLTGTHASEAHAAGRLANEEVPGEEEETSPQVQRPVAEGTVADSAPAIATNDSSSRSINSANTLRPSCGPLSVLKTHGNEGSGGDVAANASESPLANDGVTFSDAVDASDTGNSTPGMDVTKKFSAPGLLTSSSVNSSSIQQQFFLKVFHSFQAHHKYILKVAISPNIDILVTCCGDYTVGRFVIPPILQCCDVTTKHASGCESDSHSAGVSSLTSAVRLSGLTEKNTAAGSDPTNQVAAAGDNNGAGAGGATAASSSSLLQPKADEGAVLTPTAAPSTSFTHDGSTGSVEDGVKPVAAVANDPTVNESQPLATMETVKKMTSPADAPTERHDAFHLATSNFPQLVAEGSTQVNIGDGVEFKELKPLTGHTRWVWDCAFSDCGRFLFTASSDQTLRMWTSLLSDRPHSTSFVGHMKPVVCCMLYVERKKNQ
Protein: ABC transporter (Q6X4V5)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRTSPSNTAMMEIQANKPAGTGMVVGGLSPLSETLWREKTDTELMGDVSARLTWEDLTVMVTLSNGATQKVLEGLTGYAEPGTLTALMGPSGSGKSTLLDALSSRLAANAFLSGTILLNGRKTKLSFGTAAYVTQDDNLIGTLTVRETISYSARLRLPDTMPWSAKRDLVEGTIIEMGLQDCADTVIGNWHLRGISGGEKRRVSIALEILMRPRLLFLDEPTSGLDSASAFFVTQTLRGLSRDGRTVIASVHQPSSEVFELFDQLYLLSEGKTIYFGQASEAYEFFAQAGFPCPALRNPSDHFLRCINSDFDKVKATLKGSMKLRFEASDDPLEKITTTEAIRTLINFYRTSHQCYAAKEKVDEISKVRGTVLDSGGSQASFLMQSYTLTKRSFVNMSRDFGYYWLRLLIYVVVTVCIGTIYLNIGTSYNSILARGACASFVFGFVTFMSIGGFPSFVEDMKVFQRERLNGHYGVTAFVIGNTLSAMPFLIMITFISGTICYFMVRLHPGFEHYMFFVLCLYASVTVVESLMMAIASIVPNFLMGIITGAGIQGIFMLVSGYFRLPNDIPKPVWRYPMSYISFHFWALQGQYQNDLKGLLFDNQPPELPKIPGEYILENVFQIDVGRSKWIDLSVIFSMIIIYRIIFFLMIKISEDVTPWIRGLVARRRMQQKNGTQNTMVAPSLSQSPSLRNYVANRANGRGKR
Protein: Bradyzoite pseudokinase 1 (Inactive serine/threonine-protein kinase BPK1) (A0A7J6KD88)
Organism: Toxoplasma gondii
Function: Required for the growth, maintenance, and/or stability, and thus infectivity, of bradyzoite cysts.
Subcellular location: Secreted {ECO:0000269|PubMed:22021236, ECO:0000269|PubMed:23291621}. Note=During the bradyzoite stage, secreted into the cyst lumen and localizes to the cyst wall. {ECO:0000269|PubMed:22021236, ECO:0000269|PubMed:23291621}.
Interaction partners:
Sequence:
MANTSVRRRQLLSSVLLLQWLTTVLGVAWGPNPIDGSKHGQFPSLRRTEGVSQSGSGHKGSVYRIPLADMTFWSWMSYLKELPDIDESRNPILKRLLSGSFLRRDGSTTVNVRVPARELVRLLSLTPEQQREGVSAKVRLINLLDPKYSVYEPYLYREILPKRSPLLLPSLGEYRGAFLTYIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNLVQLLGNGNIGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEEGKARPFRYKQNRL
Protein: Lymphocyte antigen 6 complex locus protein G5b (Q8K1T4)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Casein kinase II subunit beta
- Casein kinase II subunit alpha
- Casein kinase II subunit alpha'
- Ribosomal RNA-processing protein 7 homolog A
- Lymphocyte antigen 6 complex locus protein G5c
- FACT complex subunit SPT16
- Nucleolar protein 6
- WD repeat domain 36
- Lymphocyte antigen 6 complex locus protein G6c
Sequence:
MRARVLVGMLTMVGFAMGKAPVARVRTCHLCLLEDPSLGCISGSEKCTISLPSPCMVITIYKNTTVRFHVRGCGQHHSYRCQERHVIYQSDYLYKADCCQYDYCNSWSSAQHQSTLRGSPGSHLGMPLSASQIKQFYQALNLSLPQPGFHAHKVSEGLESLILPPELGLSIADLRQIYLFLNSSGLLVLPWDRP
Protein: Proteasome maturation factor UMP1 (P38293)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. Required for the correct assembly and enzymatic activation of the proteasome. Also prevents premature processing of the PRE2 propeptide.
Interaction partners:
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-3
- Proteasome assembly chaperone 2
- Proteasome subunit beta type-6
- Proteasome subunit beta type-2
- Proteasome subunit beta type-5
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-3
- Probable proteasome subunit alpha type-7
Sequence:
MNIVPQDTFKSQVSTDQDKSVLSSAVPSLPDTLRQQEGGAVPLSTQLNDRHPLESTLKNWETTQRQRQMEQYRQIFGIAEPMKRTMEMEIVNRTDFNPLSTNGSIHRDILLNKECSIDWEDVYPGTGLQASTMVGDDVHSKIEKQLGI