wanglab/gogpt-training-data huggingface dataset:
Protein: Sphingosine-1-phosphate phosphatase 2 (SPPase2) (Spp2) (EC 3.1.3.-) (Sphingosine-1-phosphatase 2) (Q810K3)
Organism: Mus musculus (Mouse)
Function: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (Probable). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (By similarity). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IWX5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IWX5}.
Interaction partners:
- Sphingosine-1-phosphate lyase 1
- Sphingosine kinase 2
- Phospholipid phosphatase 2
- Sphingosine kinase 1
- Ceramide glucosyltransferase
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Phospholipid phosphatase 3
- Ceramide synthase 4
- Acid ceramidase
- Neutral ceramidase
Sequence:
MAELLRSLRDSQLVARFQRRCGLFPAREASGEEHVVKNYFYYYLFRFSAALGQEVFYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKRIIAEYGMPSTHAMAATAISFTLLISTMDRYQYPFILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTYPAWTLIDSLDSASPLFPVCVIVVPFLLCYNYPVSDYYSPTRADTTTIVAAGAGVTLGFWINHFFQLVSKPTPSLPVIQNIPPLTTDMLVLGLTKFMVGIMLILLVRQLVQKLSLQVLFSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLL
Protein: Complement factor H-related protein 5 (FHR-5) (Q9BXR6)
Organism: Homo sapiens (Human)
Function: Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.
Subcellular location: Secreted.
Interaction partners:
- Complement C3
- Pentraxin-related protein PTX3
- C-reactive protein
- Complement factor B
- Complement factor H-related protein 4
- Coagulation factor IX
- Rap guanine nucleotide exchange factor 1
- Complement factor H-related protein 2
- Diacylglycerol kinase epsilon
- Myosin-binding protein H
Sequence:
MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE
Protein: NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) (Q8BZ02)
Organism: Mus musculus (Mouse)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}.
Interaction partners:
Sequence:
GPLFRTIVLDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPNVFFWLAGDPCPQPSQLSAKGLPACAPLFIRDYFEGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRKRNFKRLQRQDRQSIMSEKLVGGVEALEWQGRNEPCRPVLVHLQPGQIRVVDGRLTVLRTIQLRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVENVRGALKENGLSFQEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPLDSSTKVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPRMSAHCARNNMKTASSPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQTVQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRLIASTAIILTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLLALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDRQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF
Protein: LEFTY-1 protein (Q9PUK3)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
HKRDLVDLVIPEHVKNKYISMLKRHRGKRRASPSLASILQGIPGNAEVFYSDPMRQNFIFDMEGRIPKNSEVTMAELKLFKKPLDRVNLPARQPHRPVSNARVSIYWVQRQHDGTNRTSLIDSRLVPIRESGWKNFDVTQAVHYWLRNKRQEPMVLQVWIEGERVASYAAEVAKSVRFTSQDAGDRAVGRPELVLYTLDLEDYGGPGDCKDGVQAGKSTCCRQKHYINFRELSWTQYWVIEPAGYQAYSCRGGCLQLPGPLQLWGGRERACAVAESSPLPIMYLVRRGNHTEIEATEFPNMIIEKCSCMADGADFCEGLT
Protein: Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) (Q8NFQ8)
Organism: Homo sapiens (Human)
Function: Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity.
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane.
Interaction partners:
- Torsin-1A
- Torsin-1B
Sequence:
MADSGLREPQEDSQKDLENDPSVNSQAQETTIIASNAEEAEILHSACGLSKDHQEVETEGPESADTGDKSESPDEANVGKHPKDKTEDENKQSFLDGGKGHHLPSENLGKEPLDPDPSHSPSDKVGRADAHLGSSSVALPKEASDGTGASQEPPTTDSQEAQSPGHSSAGQEGEDTLRRRLLAPEAGSHPQQTQKLEEIKENAQDTMRQINKKGFWSYGPVILVVLVVAVVASSVNSYYSSPAQQVPKNPALEAFLAQFSQLEDKFPGQSSFLWQRGRKFLQKHLNASNPTEPATIIFTAAREGRETLKCLSHHVADAYTSSQKVSPIQIDGAGRTWQDSDTVKLLVDLELSYGFENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLEASVGPRETEEKVRDLLWAKFTNSDTPTSFNHMDSDKLSGLWSRISHLVLPVQPVSSIEEQGCLF
Protein: Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (A4QPA9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000256|ARBA:ARBA00004317}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
Protein: Protein ETHYLENE-INSENSITIVE 3-like 2 (EIN3-like protein 2) (OsEIL2) (Q8W3L9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor acting as a positive regulator in the ethylene response pathway. Involved in wound signaling by binding specifically to the DNA sequence 5'-ATGTACCT-3' found in the promoter of some wound-inducible genes. Required for ethylene-promoted coleoptile elongation. Acts as negative regulator of salt tolerance. During salt stress, activates the cation transporter HKT1, which mediates increased sodium uptake in roots, and contributes to sodium accumulation and salt toxicity. Possesses transactivation activity in protoplasts.
Subcellular location: Nucleus {ECO:0000269|PubMed:25995326}.
Interaction partners:
- Protein ETHYLENE-INSENSITIVE 2
- Os06g0605900 protein
- Os02g0200900 protein.
- Mitogen-activated protein kinase 1
- Os07g0156732 protein
- Mitogen-activated protein kinase 5
- AP2 domain containing protein, expressed
- Os09g0572000 protein
Sequence:
MMGAAVTMVDRRMAFAAEADVDSKAAFGFFGGECFVGEGDLVNPAPPPPQQQQVHEGGFAAEDESDGDDDDDDDDDVDDIEELERRMWRDRVRHKRLKELQQSRAGRESRAGDAGGGGRQQRQSQEQARRKKMSRAQDGILKYMLKMMEVCNAQGFVYGIIPEKGKPVSGASDNLRSWWKEKVRFDRNGPAAIAKYQADNAVPGCDGDAGGAAPAGPHSLHELQDTTLGSLLSALMQHCDPPQRRFPLEKGVPPPWWPEGSEAWWPEAGVPKELGPPPYKKPHDLKKAWKVAVLTAVIKHMSPDVDKVRRLVRQSKCLQDKMTAKEIVTWLAVLKQEEDLYLKLHPGALPPPLSAASFNASVSGEYDVEGVDGDEAGNNNLQKAQNDATAFMDLTTTMDAALSNNKFLIMPLMKEEAIDVDFIQKRSEPELMLSSDSHARVYTCGNVQCPHSNYALGFLDRNERNAHQYACKHNAAAAAAESKPPPPHIFEPLGSFDFDLPVDGQRCLAGLMTMYDNDVAAATQMHHHHHQQQQANFFIRDDAPFGGDVAATAAAAPEFRFSSNFNVTGGGAVDYGGAMQQPPAKYAGSNWFY
Protein: SnoRNA-binding rRNA-processing protein (Q5A756)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Utp5p
- Utp9p
- Utp13p
- Ribosome biosynthesis protein
- Nucleolar protein 58
- Utp20p
- SnoRNA-binding rRNA-processing protein
- Nan1p
- rRNA-processing protein
- SnoRNA-binding rRNA-processing protein
Sequence:
MVKSYNRYDQEKCFGVITSQANIVWLPPSETQSSTSMGRALTSGLEEILIWDIKTGEIMNRMSDGLTPGSSNASTTVPPSPVSYLTYHQETNIIAAGYTDGSIKIWDISSNSVIINFEGHNSSITQLKFDKNGTRLVSGSSDSSIIMWDLIGEVGMFKLKGHKGPITGLELLSEQQNTQQDGDNVDDVDDMDDYLVSVSKDGLIKLWELKSQQCIETHLAHSNECWAMGINPTKDMLITSGNKDQVKVWSLDLSLEDGLKIGERGSFEKTSKSRSNEIAFKSLKSSSSSASLIQLFSIQNADRTMEIFRIRSEDEIKRGITKRTKRLKDKGLDEQEILESLQSSEISMLITPFTTMRTMAKIKSACWTNNIKKLDILMSLTNNSIEYHTIPVPETPKKAQSADLYSVKQHTIDLLGHRFDIRAMDISPQDNKLLATASNGELKIWNTRSYNVIRTFVLEGGYALCCKFLPGGTLIVVGFKNGDLELYDLATSSLVDRVEKAHSAITVGGAAPSNDDSAAIWSLDITPDGKTLVTGGNDKCVKFWNFKVEQDIIPGTNTTVSHLKFVHTQTLELNEDVLCVRISPDAKYLAISLLNNNVQVVFLDTLKLFLTLYGHRLPVLSIDISHDSKLIITSSADKNIKIWGLDFGDCHKSIFAHQDSIMNVRFIGDTHNFFSSGKDGLIKYWDGDKFECIQRLPAHQSEVWCMAISDDGLFMCSTSHDHSIRLWSATDDQVFLEEEKEKELDEIYENKLLDQIDGVDGEDHTNMKDDNDEEIDEATKVSKQTMETLKAGEKLMEALDIGVEDIEANKEYLSLVKQGKQAIKPTPNSILLAFNMTASQYVLNVLSKIRPAQLDDALLVLPFSYSLKLLQFIEIWTNKENITQNVVSISLICKVLFFVISSNSKELISQKDPHLKNQLIKVKEQLRQELSKTSNQLGVNTQGLKFVKKQWKLQHASEFIDEEEQRQYEEKRAIKRTYTTI
Protein: Pre-mRNA-splicing factor 38 (Q9UUD2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels. Implicated in the formation of stable and biologically active snRNP structures. As part of the U4/U6.U5 tri-snRNP particle, dispensible for spliceosome assembly, but required for conformational changes, which result in U4 snRNA release and the subsequent catalytic activation of the spliceosome (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized protein C1782.03
- Pre-mRNA-splicing factor dre4
- U4/U6.U5 small nuclear ribonucleoprotein component snu23
- U4/U6.U5 tri-snRNP-associated protein snu66
- U4/U5/U6 small nuclear ribonucleoprotein prp3
- Pre-mRNA-processing factor 31
- Pre-mRNA-splicing factor prp1
- Pre-mRNA-splicing factor spp42
- Small nuclear ribonucleoprotein G
- Uncharacterized WD repeat-containing protein C227.12
Sequence:
MADFLARDYRSQGEAAHEMLPTFLIGKILRERIVDSIYWKEQCFGLNACSLVDRAVRLEYIGGQYGNQRPTEFICLLYKLLQIAPEKEIIQQYLSIPEFKYLRALAAFYVRLTWDDVEVHQTLEPLLRDYRKLRIRTNSEIRLTYLDEVVDDLLNAEVVCDISLPPLRSRLQLEDLDLLEPLSSSSDEEDDDEEQISKLESNEGAVDRNI
Protein: Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) (O70572)
Organism: Mus musculus (Mouse)
Function: Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (By similarity). Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:9520418}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sphingomyelin phosphodiesterase 3
- Sphingomyelin phosphodiesterase
- Sphingomyelin phosphodiesterase 4
- Protein FAN
- Ceramide glucosyltransferase
- Ceramide synthase 2
- Phosphatidylcholine:ceramide cholinephosphotransferase 2
- Ceramide kinase
- Ceramide synthase 5
- Ceramide synthase 4
Sequence:
MKLNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLENFDLALLEEVWSEQDFQYLRQRLSLTYPDAHYFRSGMIGSGLCVFSKHPIQEIFQHVYSLNGYPYMFHHGDWFCGKSVGLLVLRLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKNADVVLLCGDLNMHPKDLGCCLLKEWTGLHDAFVETEDFKGSDDGCTMVPKNCYVSQQDLGPFPSGIRIDYVLYKAVSEFHVCCETLKTTTGCDPHSDKPFSDHEALMATLYVKHSPPQEDPCTACGPLERSDLISVLREARTELGLGIAKARWWAAFSGYVIVWGLSLLVLLCVLAAGEEAREVAIILCIPSVGLVLVAGAVYLFHKQEAKGLCRAQAEMLHVLTRETETQDRGSEPHLAYCLQQEGDRA
Protein: Mitogen-activated protein kinase kinase kinase kinase (EC 2.7.11.1) (A0A0B4LGY8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAAAHSHHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPAQNHTLKTGMTTNSTWNERSSSPETLPSDIPSAERSKPKLSGTLIMNMSLRSLLQYIDEELKLSGDAVVGGNGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPRTRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMSLSGKSCQLYRHDLVALHSKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPVFEMIITPELEYPIVCTGVRKAMNGCLKLELINMNSASWFHSEDLEYDAMATMVPRRDLLKVVRVHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY
Protein: At4g24340 (Phosphorylase superfamily protein) (Q8GW53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Fanconi anemia group E protein FANCE protein
- At5g01015
- Pentatricopeptide repeat-containing protein At2g18520
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- ARM repeat superfamily protein
- Small ribosomal subunit protein mL103
- RING-type E3 ubiquitin transferase
- Fanconi anemia group F protein
- ATP-dependent protease La
- Fanconi anemia group I-like protein
Sequence:
MASMDHNHFLFPLLFIIIISSLHVLRASTTPSHSHKLKSATTIRKINRRGPYIGLVTVFETEEDAFLGSVDFRLDPTHPFLDLSGRRFRIGKIHGKKVVYVRCGIGMVNAAAATQQMIDVFSVKGIVHFGIAGNINNSMSIGDVSIPKQITNAGLWDWLNPGKAKGNEDVAYLDVGNYNVPQGNNKLGTIGYSYEELYSVSGHINSPKKVFWINTTQEWLHLAADLEKMELLQCVNASLCLPNKPKVVVGLKAATADIFVDNAAYRNFLYDTFGVSSSDMESSAVAMTCVSNGYPLIVIRGLSDLAGVGDNTVRKFGSLAATNTAKAVLEFIKKLPPS
Protein: Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5) (Q96PP8)
Organism: Homo sapiens (Human)
Function: As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8CFB4}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:17266443, ECO:0000269|PubMed:21151871, ECO:0000269|PubMed:26996307, ECO:0000269|PubMed:31091448}; Lipid-anchor {ECO:0000269|PubMed:21151871}. Cytoplasm {ECO:0000269|PubMed:17266443, ECO:0000269|PubMed:21151871}.
Interaction partners:
- Guanylate-binding protein 2
- Signal transducer and activator of transcription 1-alpha/beta
- Guanylate-binding protein 1
- Guanylate-binding protein 4
- Basic leucine zipper transcriptional factor ATF-like 2
- NACHT, LRR and PYD domains-containing protein 3
- Interferon regulatory factor 1
- Acyl-coenzyme A synthetase ACSM1, mitochondrial
- C-X-C motif chemokine 9
- C-X-C motif chemokine 10
Sequence:
MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL
Protein: NAC domain-containing protein 59 (ANAC059) (AtNAC3) (Protein ORE1 SISTER1) (Q9LJW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that binds to DNA in promoters of target genes on a specific bipartite motif 5'-[AG]CGT[AG](4-5n)[AG][CT]ACGCAA-3'. Triggers the expression of senescence-associated genes during age-, salt- and dark-induced senescence through a regulatory network that may involve cross-talk with salt- and H(2)O(2)-dependent signaling pathways.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9FKA0, ECO:0000255|PROSITE-ProRule:PRU00353}.
Interaction partners:
- Gb|AAF63169.1/surp domain-containing protein)
- Uncharacterized protein At5g39520
Sequence:
MDYKVSRSGEIVEGEVEDSEKIDLPPGFRFHPTDEELITHYLRPKVVNSFFSAIAIGEVDLNKVEPWDLPWKAKLGEKEWYFFCVRDRKYPTGLRTNRATKAGYWKATGKDKEIFKGKSLVGMKKTLVFYKGRAPKGVKTNWVMHEYRLEGKFAIDNLSKTAKNECVISRVFHTRTDGTKEHMSVGLPPLMDSSPYLKSRGQDSLAGTTLGGLLSHVTYFSDQTTDDKSLVADFKTTMFGSGSTNFLPNIGSLLDFDPLFLQNNSSVLKMLLDNEETQFKKNLHNSGSSESELTASSWQGHNSYGSTGPVNLDCVWKF
Protein: Nucleoporin nup184 (Nuclear pore protein nup184) (Q9P7M8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Interacts with pom152 in the core structure of the nuclear pore complex (NPC). Involved in the export of mRNA.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10388805}.
Interaction partners:
- Meiotically up-regulated gene 87 protein
- Nucleoporin nup186
- Nucleoporin nup189
- Nucleoporin nup44
- Probable nucleoporin C890.06
- Nucleoporin npp106
- Poly
- Nucleoporin nsp1
- Nucleoporin seh1
- Nucleoporin nup45
Sequence:
MGDYLLSWSWILDAFETSDENLSQNKFEELLDARIAAFQQIESPVTGTLNSNKTTEGEEAKLSIYDSSHSISKSQLESVKKISDITGYNEAQVAYVLLVHQYELNTQYFSQLDNDSVLAQEFQRRYYAEIISCWKVLAFLLQACTDADSKWHKMATRLIVSIFQTAQRSGENAQSTTPSIFCVRIIDYLSKMTSQAAPASLTFNGEEAISQWYFFHFNLQLQLLRVIFLSTYSLVVCNSEMAISWFNCMKKTRYLHDQEFMHLDIDTGFSMCKEITNVAIIISINFISLEKQVLSFKDNPSFFMLSGNTIISLHDMITQLSNDSIGAAVSLTWGIALHLLSNSPDNIPLIQNSSVVSSKILQNPQNSFQALIIAALKYDPFTLIHRIISSLEDDPYIDGYSKIMATLFSSAVSYVKFSDSTMLCATTLFKTPQVYQLFENNDSVTRLLNFARARFPFEYSQFVLLLIPTFACLTSKQLVSSELLHMTTFTQSLPSGFKAYEIIPEPNVTGNALIELQESLHLDSYGFFFPNAERSLPKGTRGRIVSVDTYPPVVMWDLNYSLWEAVGISLNYIVRNGLINSHKSFVLTVLSSSVPLFQTDVSGACELVHLASEGLDGELDFINVICDLLDYFLSLSVIEDADYQICVSSLRLLREFTRFAATDVWAYVTRSLVCVGSEKGISLEDVIFDYESINGVYDFTLAFFDLYEILLDNCISTSVVPDDFSIRLKTDFVKRAMRFLCEVFANYLDWKYARIIQQYQIGHRFASLITKLLNVTFGIEYFNPKTTVNKKTLPLRELSHYIVQRFLVQQDSNRYLHPLLSVMDLINLLYTDIFSTISSPRAKAAKMWLISSFCAMKTLICLRGFLNLKPSELERELFSRSPDLFNCLPRLLCCIAPILQLLSALILAPWPSETPSLLAYMINSTDIVGRVCIQILTNPIQSTNIEGSVWKFLSSIMKGQQQGLAVLLFSGKKFPLDRMKSLNHNVDVQLTSKSLISLAEKRLDSFSINDILSQVPVFEFIFLSRNFWTASLGNLQQEANFWNRIVDAIKLPLTVKLDGLSSVAQADLYILAAHATRITAIQLHMSKLNKSNSSKKIIIDPLKDSMKDLVQHAFTITAYDSNIHNALTRAFKHENGDLHISDLRNTGLFPLRYGDNYFYNIKLAKNMLLNTEDTSFKISMMMSANENLSLLDAQAALLRSWSIFICAFVEFVKEDATLSILELKIMKWVLKSLAEDTIDVNVVQELSAERAALVFRISQQTLAIPISNEVKEHLQSILLLTWKAITTTKFSIYEDSNGEMAYYRPLLHVLYNTLNRLLSEEKENLSLSVGFVSGLLQLCHRKLSQLFEKAVINPTIEVYGDIVLLNSLHKCIVNSHLIRGLQSLYISYINDSFSVDNCLRLFSWSHSLLVDGQPYFADAALSFLLICSSSPAGAEQIVMNGFFYSIMESPLSTALSTGGLGLDGSSIQYKIWIRGILPLLFNIVKFLGNRIMNDMREFVLLAFPQIQYALLNWCQPPSSISLASIDESFMIVLLFDLLQQFNPALLQEIRLAELKIEMLEASTI
Protein: Peptidyl-prolyl cis-trans isomerase FKBP7 (PPIase FKBP7) (EC 5.2.1.8) (23 kDa FK506-binding protein) (23 kDa FKBP) (FKBP-23) (FK506-binding protein 7) (FKBP-7) (Rotamase) (O54998)
Organism: Mus musculus (Mouse)
Function: PPIases accelerate the folding of proteins during protein synthesis.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:9806833}.
Interaction partners:
Sequence:
MNLLFRLAVFLSLWCCSDAQGQTKEESTEEVKIEVLHRPENCSKTSRKGDLLNAHYDGYLAKDGSKFYCSRTQDEGHPKWFVLGVGHVIKGLDIAMMDMCPGEKRKVIIPPSFAYGKEGYAEGKIPPNATLMFEIELYAVTKGPRSIETFKQIDTDNDRQLSKAEIELYLQKDFEKDANPRDKSYQKAVLEDIFKKNDHNGDGFISPKEYNVHQHDEL
Protein: Transcription elongation factor SPT4-A (DRB sensitivity-inducing factor small subunit 1) (DSIF small subunit 1) (Transcription elongation factor SPT4 1) (P63271)
Organism: Mus musculus (Mouse)
Function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription elongation factor SPT5
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB7
- RNA polymerase-associated protein LEO1
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerase II subunit RPB9
Sequence:
MALETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCDAYLQMKGNREMVYDCTSSSFDGIIAMMSPEDSWVSKWQRVSNFKPGVYAVSVTGRLPQGIVRELKSRGVAYKSRDTAIKT
Protein: Mitochondrial Rho GTPase 1 (AtMIRO1) (EC 3.6.5.-) (Miro-related GTPase 1) (Q8RXF8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mitochondrial GTPase required to maintain proper development, morphology and intracellular distribution of mitochondria, which in turn are essential for the progress of embryonic cell division, development of haploid male and female gametes, and pollen tube growth.
Subcellular location: Mitochondrion outer membrane {ECO:0000305|PubMed:18344283}; Single-pass type IV membrane protein {ECO:0000305}.
Interaction partners:
- Mitochondrial fission 1 protein A
- Kinesin-like protein KIN-14E
- Protein MOR1
- Peroxisomal and mitochondrial division factor 1
- Probable transmembrane GTPase FZO-like, chloroplastic
- At1g05270
- Dynamin-related protein 3A
- Kinesin-like protein KIN-14C
- Transducin family protein / WD-40 repeat family protein
- MICOS complex subunit MIC60, mitochondrial
Sequence:
MARYAAGAVDCPGSPKSVRIVVVGDKGTGKSSLIVAAATDSFPPNVPPVLPDYKLPIEFFPDGIPVTIVDTSSRPEDRDIVAEELKRADAVVLTYACDRPETLERLSEYWLPELRRLEVKIPIIVAGCKLDFRDDNNQVSLEQVMSPIMQQFREIETCIECSALKQLQAQEVFYYAQKTVLHPTGPLFDQDSQALKPRCVRALKRIFILCDHDRDGALSEAELNDFQVKCFHAPLQPSEIEGVKRVVQEKLPEGVNERGLTVTGFLFLHALFIEKGRLETTWTVLRKFGYNNDIRLAEELLPSAIFKRAPDQSFELTNAAIDFLKGMYMLFDDDQDNNLRPQEIEDLFSTAPESPWKEAPYEDAAEKTALGGLSFDAFLSMWSLMTLLEPARSVENLIYIGFPGDPSTAIRVTRRRRLDRKKQQCERKVFQCFVFGPNNAGKSALLNCFLGRSYTDNQESTTDERYAVNMVDESGAKKTLIMREIPEDGVQGLFSSKESLAACDIAVFVYDSSDESSWKRATQLLVEVANYGEATGYEVPCLMVSAKDDLDSSPISIQESTRMTQDMGIEPPVSISSKLGDFNNLFRKILTAAQHPHLSIPETEAGKSRKHYNRLINRSLMAVSIGAAAVVVGLAAYRVYATRKSSSA
Protein: Transcription factor AP4 (A0A2R8VI80)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPGASVLYTDLANIPLTPETQRDQERRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAEDLRREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQHLRTQLLPPPAPTHHPT