wanglab/gogpt-training-data huggingface dataset:
Protein: Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta) (P97372)
Organism: Mus musculus (Mouse)
Function: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Interaction partners:
- Proteasome activator complex subunit 1
- Proteasome subunit beta type-10
- Proteasome subunit beta type-8
- Interferon gamma
- Proteasome activator complex subunit 3
- Proteasome subunit beta type-9
- Proteasome subunit beta type-7
- Tumor necrosis factor
- Proteasomal ubiquitin receptor ADRM1
- Proteasome subunit alpha type-5
Sequence:
MAKPCGVRLSGEARKQVDVFRQNLFQEADDFLCTFLPRKIISLSQLLQEDSLNVADLSSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGYLPGNEKLLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY
Protein: Small ribosomal subunit protein uS4 (40S ribosomal protein S9) (P17959)
Organism: Trypanosoma brucei brucei
Interaction partners:
Sequence:
MRNYNNFNRVWKAPRRPFEKERLDREMKLCGQYGLRCKREIWRVNMTLSKMRRTARLLLTLPENHPRRLLEGSAIMRRCHGYGFLDEDKDKLDYVLSLTVPDILERRLQTVVFKHGLAKSVHHSRVLIQQRHIAVAKQIVTIPSFIVRVSSEHHIAFADASPFGNGRPGRVKRVKRNAAKKGSGGGDDDE
Protein: Poly(A) RNA polymerase protein 1 (EC 2.7.7.19) (Topoisomerase 1-related protein TRF5) (P48561)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic subunit of the TRAMP5 complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Polyadenylates RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. TRF5 is also required for proper nuclear division in mitosis and sister chromatid cohesion. Involved in the regulation of histone mRNA levels. May mediate mitotic chromosome condensation.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein AIR2
- ATP-dependent RNA helicase DOB1
- Protein AIR1
- Poly
- Exosome complex exonuclease RRP6
- Poly
- Probable E3 ubiquitin-protein ligase HUL4
- Exosome complex exonuclease DIS3
- Antiviral helicase SKI2
- Exosome complex protein LRP1
Sequence:
MTRLKAKYSPTKGKRKEDKHTKRMRKSSFTRTQKMLEVFNDNRSHFNKYESLAIDVEDDDTFGNLVLMENDKSDVDIPVIEEVTSSEDEQRAESSKRNNSLEDNQDFIAFSDSSEDETEQIKEDDDERSSFLLTDEHEVSKLTSQQSLNTESACNVEYPWIRNHCHSKQRRIADWLTSEIKDFVHYISPSKNEIKCRNRTIDKLRRAVKELWSDADLHVFGSFATDLYLPGSDIDCVVNSRNRDKEDRNYIYELARHLKNKGLAIRMEVIVKTRVPIIKFIEPQSQLHIDVSFERTNGLEAAKLIREWLRDSPGLRELVLIIKQFLHSRRLNNVHTGGLGGFTVICLVYSFLNMHPRIKSNDIDVLDNLGVLLIDFFELYGKNFGYDDVAISISDGYASYIPKSCWRTLEPSRSKFSLAIQDPGDPNNNISRGSFNMKDIKKAFAGAFELLVNKCWELNSATFKDRVGKSILGNVIKYRGQKRDFNDERDLVQNKAIIENERYHKRRTRIVQEDLFINDTEDLPVEEIYKLDEPAKKKQKAKKDKREGEIKKSAIPSPPPDFGVSRSKLKRKVKKTDQGSLLHQNNLSIDDLMGLSENDQESDQDQKGRDTPSGQDEKSPLETKTVDAQTRRDYWLSKGQAL
Protein: Ras-related protein RABA4c (AtRABA4c) (Ras-related protein SMG1) (Q9FE79)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intracellular vesicle trafficking and protein transport.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Ethylene-responsive transcription factor 3
- Regulator of nonsense transcripts UPF2
- Regulator of nonsense transcripts 1 homolog
- Callose synthase 12
- Regulator of nonsense transcripts UPF3
- Kinesin-like protein KIN-14E
- Nonsense-mediated mRNA decay factor SMG7
- Mitogen-activated protein kinase kinase 4
- Partner of Y14 and mago
Sequence:
MSKFQSNFNQKIDYVFKVVLIGDSAVGKSQLLARFSRNEFSIESKATIGVEFQTRTLEIDRKTIKAQIWDTAGQERYRAVTSAYYRGAVGAMLVYDITKRQSFDHVARWLEELRGHADKNIVIMLIGNKTDLGTLRAVPTEDAKEFAQRENLFFMETSALDSNNVEPSFLTVLTEIYRIVSKKNLVANEEGESGGDSSLLQGTKIVVAGEETESKGKGCCGTS
Protein: Neutral amino acid transporter B(0) (ATB(0)) (ASC-like Na(+)-dependent neutral amino acid transporter ASCT2) (Insulin-activated amino acid transporter) (Sodium-dependent neutral amino acid transporter type 2) (D3ZJ25)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q15758}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000250|UniProtKB:Q15758}.
Interaction partners:
- Sodium-dependent neutral amino acid transporter B
- High affinity cationic amino acid transporter 1
- Large neutral amino acids transporter small subunit 1
- Amino acid transporter heavy chain SLC3A2
- Sodium-coupled neutral amino acid symporter 1
- Sodium-coupled neutral amino acid symporter 2
- Sodium-coupled neutral amino acid transporter 4
- Neutral amino acid transporter 9
- Transporter
- Solute carrier family 2, facilitated glucose transporter member 1
Sequence:
MAVDPPKADPKGVVAVDPTANCGSGLKSREDQGAKAGGCCSSRDQVCRCLRANLLVLLTVAAAVAGVVLGLGVSAAGGAEALGHARFTAFAFPGELLLRLLEMIILPLVVCSLIGGAASLDPSALGRLGAWALLFFLVTTLLSSALGVALALALKPGAAFAAINSSVVDSSVHRAPTKEVLDSFLELLRNMFPSNLVSASAAFRIFATSYVSKDINTSGIHPCGACPQRSNATMDQPHCEMKMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPIGILFLVAGKIVEMKDIRQLFIGLGKYIVCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGMSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAISLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYVDRTKMPSSEPELIQVKNDVSLKPLPLATEEGNPLLKQCREPSGDSSATCEKESVM
Protein: Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (P11167)
Organism: Rattus norvegicus (Rat)
Function: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:2211693}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}.
Interaction partners:
- Cellular tumor antigen p53
- Solute carrier family 2, facilitated glucose transporter member 4
- Solute carrier family 2, facilitated glucose transporter member 2
- Neutral amino acid transporter B
- Hypoxia-inducible factor 1-alpha
- Basigin
- Large neutral amino acids transporter small subunit 1
- Amino acid transporter
Sequence:
MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
Protein: Pentatricopeptide repeat-containing protein At2g16880 (Q9ZVX5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pentatricopeptide repeat-containing protein At1g02370
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- Nuclear pore complex protein NUP155
Sequence:
MATLKPPESQLLKTLTSILTSEKTHFLETLNPYIPQITQPLLTSLLSSPSLAKKPETLVSFFQWAQTSIPEAFPSDSPLPLISVVRSLLSHHKFADAKSLLVSYIRTSDASLSLCNSLLHPNLHLSPPPSKALFDIALSAYLHEGKPHVALQIFQKMIRLKLKPNLLTCNTLLIGLVRYPSSFSISSAREVFDDMVKIGVSLNVQTFNVLVNGYCLEGKLEDALGMLERMVSEFKVNPDNVTYNTILKAMSKKGRLSDLKELLLDMKKNGLVPNRVTYNNLVYGYCKLGSLKEAFQIVELMKQTNVLPDLCTYNILINGLCNAGSMREGLELMDAMKSLKLQPDVVTYNTLIDGCFELGLSLEARKLMEQMENDGVKANQVTHNISLKWLCKEEKREAVTRKVKELVDMHGFSPDIVTYHTLIKAYLKVGDLSGALEMMREMGQKGIKMNTITLNTILDALCKERKLDEAHNLLNSAHKRGFIVDEVTYGTLIMGFFREEKVEKALEMWDEMKKVKITPTVSTFNSLIGGLCHHGKTELAMEKFDELAESGLLPDDSTFNSIILGYCKEGRVEKAFEFYNESIKHSFKPDNYTCNILLNGLCKEGMTEKALNFFNTLIEEREVDTVTYNTMISAFCKDKKLKEAYDLLSEMEEKGLEPDRFTYNSFISLLMEDGKLSETDELLKKFSGKFGSMKRDLQVETEKNPATSESKEELNTEAIAYSDVIDELCSRGRLKEHSRSYTS
Protein: MADS-box transcription factor 2 (NMADS1) (OsMADS2) (RMADS219) (Q40702)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor involved in the development of floral organs. B-class protein required for normal development of lodicules (whorl 2).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGRGKIEIKRIENSTNRQVTFSKRRSGILKKAREISVLCDAEVGVVIFSSAGKLYDYCSPKTSLSRILEKYQTNSGKILWDEKHKSLSAEIDRIKKENDNMQIELRHLKGEDLNSLQPKELIMIEEALDNGIVNVNDKLMDHWERHVRTDKMLEDENKLLAFKLHQQDIALSGSMRDLELGYHPDRDFAAQMPITFRVQPSHPNLQENN
Protein: Plasmolipin (Plasma membrane proteolipid) (P47987)
Organism: Rattus norvegicus (Rat)
Function: Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9Y342}; Multi-pass membrane protein {ECO:0000255}. Myelin membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12871592}; Multi-pass membrane protein {ECO:0000255}. Note=In polarized cells, localized predominantly in the apical membrane (PubMed:12871592). Located in lipid raft (PubMed:12871592). Recycled between the plasma membrane and the Golgi complex (By similarity). PLLP is continuously recirculating in the cell (By similarity). {ECO:0000250|UniProtKB:Q9Y342, ECO:0000269|PubMed:12871592}.
Interaction partners:
- Opalin
Sequence:
MAEFPSKVSTRTSSPAQGVGASVSAMRPDLGFVRSALGVLALLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVFFIIYLFQLHMKLYMVPWPLVLLVFFVAATVLYITAFVACAAAVDLTSLRGSRPYNQRSAASFFACLVMIAYGLSAFFSFQAWRGVGSNAATSQMAGGYS
Protein: Uncharacterized protein (Q57WI9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSYVVGDEGCEIDLSKLISYTMSFQPLQLLFEDIIKRLKQSETANERQDNELTLLRMEMDELRRRDADREAQLQNILSRAPGAHRQQPQKPEGATVETVETEAEDSKLEQAPAEWLPPYEDRGQSDNLQPLWDEIEYLKRMVGNFCEPMNNASIEQLYHARRKVSTTQQSPLSGTDGDFVTKEKQKGGDTEGVAVGEVILQRANEELQLDGISPKEEDPTGESMQPDNRAEDVVPDQLGQQGESSLAQPSGRVTRPVSGRRMSQGRSSISGVSFTRGMSPEDSNNPESLFVRVRQDEESIGRLNRVVAEILSELKGLQKDVDLMRTVGPGDGLDAVQSARLEGVEEELEELKRRLSALEGGGMPYLGDTTDDVARTTPHEGTESSFRNSGDGDVGGVAEGDTAPEAAVEARPTGIVTGSGGDVVSSSSTQNRPANTEVRDLRARLNNLEAAFRRMNDKLLKITPTDSQPKAKETSPIPPQSVGEPASGVEKELAESKEFESGVDKGDLEQVWGAIRKLQGEAKGLGRLCATLERKKQDKGAAQESSPETGGGVSDEGQMKADKELGSKQGQESGDGSPVLADLKGDEEVKERVKDLSKRLNQLQNRLVSVEGNVLNLDDRKADYSGLQRLADDVRGLRQLLEMESSKGGSEGAAATAQKQEEQIQNVQKDLVEQMQMLQAVRDGTSGELDTLRKYVEHIDRCKADAQLVANKAERDYVENALERLMREVEQVLNTTNASLIDTLDKSLNILRDMLDGKAGKEDLVNMQRILSEEHDGGGVADVLMGFRGFRCLGCNRPVDKMRPRSLGSRLQPFVNRLPQNLPPDQIMGHVQDVPLIYNTNKDVKPSSA
Protein: Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1) (Q8CGM2)
Organism: Mus musculus (Mouse)
Function: Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19657028}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:19657028}. Note=Localized to the axoneme of outer segments and connecting cilia in rod photoreceptors.
Interaction partners:
Sequence:
MNSTPGDTRDAPAPSHPAPSHRQCLLPSVAHTPSVTEVTPAKKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRKPPKTSREPGRLQRKSPSAGQAQVFQGGHEAPETSYSWKGPVAPRRLTLVKNGDPRRQQTVVLSHKNTRSLAAFLGKASELLRFPVKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEAFRCLEMENDRGNRTRKLSSVTARSERGCWGPNAKQSVIHSRGRSGGKLRQVSLTSERSGLSDHPASGHRAWAGPALDRCPQDMPVPPGSLVAADDVEKKVCMNEDGSLSVEMKVRFQLLGEDTLRWSQRVGQASVFTAASGKGQDPREADRFCCRQEGYPWGILKPGAQGLGSYDGGCQEAFDVGQKSQPSYDIWRNPLATPEGTGPTPRRRWGLAKLSGCKSHWRQEANHRKGHDKDNLSRVSTPRHPRSVQPGSCCPWTPDGDTGSDTLHPVSSASSHNETDLESGEGLCLEDTGPHGSRPETQSTERALSDTSVSAKSREESSEGGGQLHRSSSQARVMASREQVTKGDNPCISTQSHLPLNHMGLQTEKYRQGTRGWEVSGEPELRLALVPGHSGSQDTQRDALPAPACAPAQWRQRKQKRPASVECLPSVSVPYQVAQKGHARQDHYYRDTQSSLDTALQMPMPQEREQACPGSPAPQSPSNSPSAGNQASEDLRSPFSSSLDLQEPQATSKATTIAVSGSDCVCHSTRSVEPAGDTKCQAHSSTPTPAHRGELGCLWDKAGTTPEPFSFSVLLDRCPEADDPRTYHDCCCLQAVPSSPLAAPSGQTQTSISEACLGGSSFCPTPPKEQTCFGRESASNGSTSSGHSRADGFAGPRRTLLVKSPGVRGSLEEREADGGVTPSALPYASPDAVVREWLGNIPEKPVLMTYEMADENTEVPSDGPEGPKEDSLKVLGEPSQAKQQPPEGATNEHPEPAGVLSGPGSVCCRLGGDLHPDATSGERLKAPAEAGIGEGARVDHGVSLCALPTKVAASTQIMKALLGSKPGRPSSLPEVSSTVAQRLSSSAGAFIACLARLHFFDESLGPLDGKVRLEESPKYQEMLRLFQTLWPGSELWQGQLDFSLRKLTSHQALLGTEDFTPTSSSGVDVSSGSGGSGESSVPCVMDNTLAPEKRDLPLKIPSQRPDSRNQGYPELVGHSTVSSVSQVRACATGGEETGKGGRKQTWGNAPEQSVHSTMLEGDALSEETEGRVRERLQENSVHGKGLPEEGVRVCSQEMLAAGSQDGAGSPEDTRVPTDEAGADAASGGLWPLDGREEPTESPQHFSESNSRVREHQSAHKLELGLEEVSRLDARGCKQACIKASSGTMAHKGSLDPDPIWVSKLLKKIEKAFMAHLADATAELRARWDLHDNHLLDQMVTELEQDVGRRLQASTVMEVRKIQSRAGRMVPEPPREALRGQASLQTEQRRRRLQGLRNFSAVPGQGPLSLTLEDGPTLKTALGTKSGAEPAEDEFCPCEICLKKKRTPRFPKDAATVSGAPVRKAFDLQQILQSKKGGSSNREAMEVAPQRTGRMLSQEDLGTVQGADEKQGLGVAEGEEGEGKQRLRAEEDPEILKTEGSGCCAPEEDEATEEDGEICIGTAQESQQLEGTEMGKEGTLPQSFRDGGTLEAPARQGTHSVEIQEASRERQQEVEGRHQDVKEDSPWVSSGESQGRVGSENTSLDQEGRLLNHHQRPGPQSHHTACSSRALSLDNSSQVSQKGSDGDLTSGDLKCTKAKNSRVLHAEKKVPVMYPERSSSEQEVPSSPRLPKQGKGEDEGSAGSLACTQVGGKVDGFGQDDLDF
Protein: Small ribosomal subunit protein eS1 (40S ribosomal protein S1) (S3aE) (P40910)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03122}.
Interaction partners:
- Small ribosomal subunit protein eS30
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein uS8A
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS13
- Eukaryotic translation initiation factor 5A
- Small ribosomal subunit protein eS24
Sequence:
MAVGKNKRLSKGKKGLKKKVVDPFTRKDWFDIKAPTTFENRNVGKTLINRSTGLKNAADGLKGRVFEVCLADLQGSEDHSYRKIKLRVDEVQGKNLLTNFHGLDFTSDKLRSLVRKWQSLVEANVTVKTSDDYVLRVFAIAFTKRQPNQIKKTTYAQSSKLREVRKKMIEIMQREVSNCTLAQLTSKLIPEVIGREIEKSTQTIFPLQNVHIRKVKLLKQPKFDLGSLLALHGEGSTEEKGKKVSSGFKDVVLESV
Protein: Methylmalonyl-CoA epimerase (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase) (O58010)
Organism: Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Interaction partners:
- 147aa long hypothetical methylmalony-CoA mutase
- 563aa long hypothetical methylmalonyl-CoA mutase
- Putative GTPase PH0274
- 136aa long hypothetical NADH-plastoquinone oxidoreductase subunit
- 206aa long hypothetical NADH-plastoquinone oxidoreductase subunit
- 394aa long hypothetical NADH-ubiquinone oxidoreductase subunit
Sequence:
MIWMFKRIDHVGIAVKNLEEAIKIWEGLGFKVEEIEEVPDQKVKVAVIKVGENRIELLEATTEDSPIAKFIEKRGEGIHHLAIRVENIESKLEELKQKGYKLIDEKPRVGAGGAKIAFIHPKSVTGVLLELCERKE
Protein: Cytochrome P450 7B1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (25/26-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.29) (3-hydroxysteroid 7-alpha hydroxylase) (Oxysterol 7-alpha-hydroxylase) (O75881)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position. Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase. Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene-3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids. Via its product 7-alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein-coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response (By similarity). 7-alpha hydroxylates neurosteroids, including 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning. Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:9802883}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305|PubMed:9802883}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cholesterol 25-hydroxylase
- 3 beta-hydroxysteroid dehydrogenase type 7
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
- Sterol 26-hydroxylase, mitochondrial
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Sulfotransferase 2B1
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Steroid 21-hydroxylase
- Steryl-sulfatase
Sequence:
MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFRYKVKS
Protein: Transcription initiation factor TFIID subunit 12 (TBP-associated factor 12) (AtTAF12) (Q9SR71)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 6b
- Transcription initiation factor TFIID subunit 4
Sequence:
MDQPRQSSTASQPPETPPQPSDSKPSTLTQIQPTPSTNPSPSSVVSSIPSSPAPQSPSLNPNPNPPQYTRPVTSPATQQQQHLSQPLVRPPPQAYSRPWQQHSSYTHFSSASSPLLSSSSAPASSSSSLPISGQQRGGMAIGVPASPIPSPSPTPSQHSPSAFPGSFGQQYGGLGRGTVGMSEATSNTSSPQVRMMQGTQGIGMMGTLGSGSQIRPSGMTQHQQRPTQSSLRPASSTSTQSPVAQNFQGHSLMRPSPISSPNVQSTGASQQSLQAINQPWLSSTPQGKPPLPPPSYRPQVNSPSMQQRPHIPQQHISTSAATPQPQQQQSQQQHQPQEQLQQLRSPQQPLAHPHQPTRVQGLVNQKVTSPVMPSQPPVAQPGNHAKTVSAETEPSDDRILGKRSIHELLQQIDPSEKLDPEVEDILSDIAEDFVESITTFGCSLAKHRKSDILEAKDILLHVERNWNIRPPGFSSDEFKTFRKPLTTDIHKERLAAIKKSVTATEAANARNQFGHGTANARGGQAKTPSNPMGSTTFNH
Protein: Lithostathine-1-alpha (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) (Regenerating islet-derived protein 1-alpha) (REG-1-alpha) (Regenerating protein I alpha) (P05451)
Organism: Homo sapiens (Human)
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
Subcellular location: Secreted.
Interaction partners:
- Lithostathine-1-beta
- Regenerating islet-derived protein 3-alpha
- Endoribonuclease ZC3H12A
- Colipase
- Defensin-6
- Defensin alpha 5
Sequence:
MAQTSSYFMLISCLMFLSQSQGQEAQTELPQARISCPEGTNAYRSYCYYFNEDRETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESGTDDFNVWIGLHDPKKNRRWHWSSGSLVSYKSWGIGAPSSVNPGYCVSLTSSTGFQKWKDVPCEDKFSFVCKFKN
Protein: Alkaline proteinase inhibitor (E0SC34)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
Interaction partners:
- serralysin
- serralysin
- Alkaline protease secretion ATP-binding protein aprD
- serralysin
- Membrane fusion protein
- Outer membrane exporter of proteases
- serralysin
Sequence:
MKQLIIATLLSALSGGCMASSLRLPSAAELSGQWVLSGAEQHCDIRLNTDVLDGTTWKLAGDSVCLQKLLPEAPVGWRPTPDGLTLTQADGSAVAFFSRNRDRYEHKLVDGSVRTLKKKA
Protein: Protein O-mannosyl-transferase TMTC3 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 3) (Transmembrane and tetratricopeptide repeat-containing 3) (Q8BRH0)
Organism: Mus musculus (Mouse)
Function: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6ZXV5}.
Interaction partners:
Sequence:
MLEGKMADINFKEVTLIVSVVAACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNTVFHAVVSVIFLKVCRLFLDKRSSMIAALLFAVHPIHTEAVTGVVGRAELLSSVFFLAAFLSYTKSKGPDNSIVWTPIVLTVFLVAVATLCKEQGITVVGICCVYEVFVAQGYTLPMLCTVAGQFLRGKGSIPLSMLQTLVKLIVLMLSTLLLVVVRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESFLDVRNLATFAFFCFLGALGIFSLRYPGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISNKSVLKKLSWVCLSMVILTHALKTLHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFEKALKYFLQATHVQPDDIGAHMNVGRTYKNLNRSREAEASYMLAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVYIELKEPNEALKNFNRALELNPKHKLALFNSAILMQESGEVKLRPEARKRLLNYVNEEPQDANGYFNLGMLAMDDKKDSEAESWMKKAIKLQPDFRSALFNLALLYSQTAKELKALPILEELLKYYPDHTKGLILKGDILMNQKKDIPGAKKCFEKILEMDPSNVQGKHNLCVVYFEEKELLKAERCLVETLALAPHEEYIQRHLSIVRDRISSSGIVEQPLAPADKTPGTEEREEIPSEDVKEISSESRPPQILKTNNNRNSKSNKQSTENADQDAPHKTTKDIKEIEKKRVAALKRLEEIERILNGE
Protein: Protein FAM217A (Q8IXS0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGRRNENCANSLRVSNISQENLSHWNLDSEVPVSENKNLPAGRDGAAGGKINKNYLEIPVEQLMLEPNLSVHSQKSTQNSKQGIFQLWNCPLNEGSTIEKREFKKSSVETGFNVINHPIRVFTLNHPLTIASVDKQVGPYPGLPMPLGLCWPYADGDFFKNRNEIHVSSCSTIENNDGETLPAPNWNLKHGNSSVEENFTDESDLSENEKTNDTLLSYFKKVDLNLKPETIKNVEEPFTEEPNEVFPYPDFLPPPFSALDLHNLALSKSDNWKVTVDPAETSVEHLITRLLELERLQHMTIQKERPRLQTTFCTPAVTERPSSSKATPKVRQPKLCDSLSLQIPCVDKSQEKSKNNSGSCKLEQNALKRNWSNAGKYRWNSRPLSLKSSSTPKQLIETYDKNPKSSILSPCQELSFKPTIGHTNQSMVKMVSTRCLPWRSPMPVSPIPLTFPENQKEEIKAPKRNFGTKKKLYRQNIVLNRPFSIQKLNCLSPSLIAKDKCCSPIEQK