wanglab/gogpt-training-data huggingface dataset:
Protein: Small ribosomal subunit protein eS28 (40S ribosomal protein S28) (P62859)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62857}. Cytoplasm {ECO:0000250|UniProtKB:P62857}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6QAT1}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62857}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P62857, ECO:0000250|UniProtKB:Q6QAT1}.
Interaction partners:
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS2
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS10
Sequence:
MDTSRVQPIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREGDVLTLLESEREARRLR
Protein: Putative cytosolic acyl coenzyme A thioester hydrolase-like (EC 3.1.2.2) (Acyl-CoA thioesterase 7-like) (Q6ZUV0)
Organism: Homo sapiens (Human)
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MIKEAGAIISTRHCNPQNGDRCVAALARVECTHFLWPMCIGEVAHVSAEITYTSKHSVEVQVNMMSENILTGAKKLTNKATLWYAPLSLTNVDKVLEEPPVVYFRQEQEEEGQKRYKTQKLERMETNWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHSFVHEGVTMKVMDEVAGILAARHCKTNLVTASMEAINFDNKIRKGCIKTISGRMTFTSNKSVEIEVLVDADCVVDSSQKRYRAASVFT
Protein: Wall-associated receptor kinase 4 (EC 2.7.11.-) (Q9LMN6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- At4g33840/F17I5_30
- Glycosyl hydrolase family 10 protein
- Glycosyl hydrolase family 10 protein
- Glycosyl hydrolase family 10 protein
- At4g38650
Sequence:
MKVQRLFLVAIFCLSYMQLVKGQTLPRCPEKCGNVTLEYPFGFSPGCWRAEDPSFNLSCVNENLFYKGLEVVEISHSSQLRVLYPASYICYNSKGKFAKGTYYWSNLGNLTLSGNNTITALGCNSYAFVSSNGTRRNSVGCISACDALSHEANGECNGEGCCQNPVPAGNNWLIVRSYRFDNDTSVQPISEGQCIYAFLVENGKFKYNASDKYSYLQNRNVGFPVVLDWSIRGETCGQVGEKKCGVNGICSNSASGIGYTCKCKGGFQGNPYLQNGCQDINECTTANPIHKHNCSGDSTCENKLGHFRCNCRSRYELNTTTNTCKPKGNPEYVEWTTIVLGTTIGFLVILLAISCIEHKMKNTKDTELRQQFFEQNGGGMLMQRLSGAGPSNVDVKIFTEEGMKEATDGYDENRILGQGGQGTVYKGILPDNSIVAIKKARLGDNSQVEQFINEVLVLSQINHRNVVKLLGCCLETEVPLLVYEFISSGTLFDHLHGSMFDSSLTWEHRLRMAVEIAGTLAYLHSSASIPIIHRDIKTANILLDENLTAKVADFGASRLIPMDKEDLATMVQGTLGYLDPEYYNTGLLNEKSDVYSFGVVLMELLSGQKALCFERPQTSKHIVSYFASATKENRLHEIIDGQVMNENNQREIQKAARIAVECTRLTGEERPGMKEVAAELEALRVTKTKHKWSDEYPEQEDTEHLVGVQKLSAQGETSSSIGYDSIRNVAILDIEAGR
Protein: TNFAIP3 interacting protein 1 (E7EW15)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELTGKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKMEGTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQR
Protein: F-box/LRR-repeat protein 4 (AtFBL4) (Q9C5D2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F-box family protein-like protein
- Membrane-anchored ubiquitin-fold protein 4
- Membrane-anchored ubiquitin-fold protein 5
- F-box protein At5g36730
- F-box protein At5g36820
- Ubiquitin-conjugating enzyme E2 variant 1A
- Membrane-anchored ubiquitin-fold protein 1
- Membrane-anchored ubiquitin-fold protein 6
- Ubiquitin-conjugating enzyme E2 variant 1B
- Ubiquitin-conjugating enzyme E2 variant 1D
Sequence:
MRGHDRINNCLPEELILEIFRRLESKPNRDACSLVCKRWLSLERFSRTTLRIGASFSPDDFISLLSRRFLYITSIHVDERISVSLPSLSPSPKRKRGRDSSSPSSSKRKKLTDKTHSGAENVESSSLTDTGLTALANGFPRIENLSLIWCPNVSSVGLCSLAQKCTSLKSLDLQGCYVGDQGLAAVGKFCKQLEELNLRFCEGLTDVGVIDLVVGCSKSLKSIGVAASAKITDLSLEAVGSHCKLLEVLYLDSEYIHDKGLIAVAQGCHRLKNLKLQCVSVTDVAFAAVGELCTSLERLALYSFQHFTDKGMRAIGKGSKKLKDLTLSDCYFVSCKGLEAIAHGCKELERVEINGCHNIGTRGIEAIGKSCPRLKELALLYCQRIGNSALQEIGKGCKSLEILHLVDCSGIGDIAMCSIAKGCRNLKKLHIRRCYEIGNKGIISIGKHCKSLTELSLRFCDKVGNKALIAIGKGCSLQQLNVSGCNQISDAGITAIARGCPQLTHLDISVLQNIGDMPLAELGEGCPMLKDLVLSHCHHITDNGLNHLVQKCKLLETCHMVYCPGITSAGVATVVSSCPHIKKVLIEKWKVTERTTRRAGSVISYLCMDL
Protein: Dynein axonemal light chain 1 (LC1) (Q4LDG9)
Organism: Homo sapiens (Human)
Function: Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.
Interaction partners:
- Formimidoyltransferase-cyclodeaminase
- Dynein axonemal heavy chain 5
- O-phosphoseryl-tRNA
- Microtubule-associated protein 1B
- Dynein axonemal intermediate chain 2
- Dynein axonemal heavy chain 7
- Microtubule-associated protein 1 light chain 3 alpha
- Dynein axonemal heavy chain 3
- Outer dynein arm-docking complex subunit 1
- Dynein axonemal heavy chain 2
Sequence:
MAKATTIKEALARWEEKTGQRPSEAKEIKLYAQIPPIEKMDASLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPLEEKHSAENNWIEEATKRVPKLKKLDGTPVIKGDEEEDN
Protein: Paralemmin-3 (A6NDB9)
Organism: Homo sapiens (Human)
Function: ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling.
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Interaction partners:
Sequence:
MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGHRPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEASGPKQKTCQCCAVM
Protein: Pre-mRNA splicing factor, putative (Q385J5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cell division control protein, putative
- G10 protein
- Splicing factor YJU2
- Pre-mRNA-processing factor 19
- PRP8 protein homologue
- MI domain-containing protein
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor U5-Cwc21
- U5 small nuclear ribonucleoprotein component, putative
Sequence:
MLDRRRPRDENITPSDNPPFKGLLSMKALTTSIETGGSAGDDTEGRMTGNENAEFAYGSGFYLQEEYLERLRRRGHRLNNTETDNFGDDADNNDRSELSGSRRDRTQRGEASDVELIMDHNLQPRFFRLGNDFPAVSASSVLDGEGTNESMLPLNVITAHDTAGDIIIPVVSSSCRMAQQAQKGSTSLAALKRQQESERATREAMDTSKSQLTRLLQKGEIGQEIEVVDQSHKPKGLDSWLLDSTRDTEEDLEGEEEMLRRKVRRERIRLENSLNPSSANGAMTAETAAKEEERDVRERNYLDVQRRRQEKLDRVRDAKEKWERSTNDAEVSGARRIAILTIQRQLPIYRCKEELLRCIGENPVSIVVGETGSGKTTQLVQYLYQRGYTRGGGIIGCTQPRRLAAIGVARRVAEEMGCALGTRVGYAIHLDDNTSEDTEVKFMTDGVLLREIVRDPNVDKYSVIVLDEAHERSVNTDVLLGVLQAAVRRRSDLKLVVTSATMDILKFSKFFGNAPCYEIPGQSYEVDVQYATAPIEDYVLEAVFRVCQLHIQMPLEGKHDILVFMTGRDDVLGVCSLILRRLQEMDPKWLDSLLLLPCLSEAVGATATGVLDPTPSGMRKCVVATNVAETSLTIDGIRYVVDCGFMKTNVFRPKLGMNTLQRYPISQAQANQRKGRAGRTAEGICYRLYTESQFKHEMLLSSVPEIQRSSIDSVVLLLKSIGVSRLIDFDFMDPPPAANIRRSMWQLWVLGLLDDNGNITADGKCALEFPLAPTLAKVLIESTVRECSVEAVRVVSVISADPKGLFELPKGSEEAARQHHSRFHVNDSDHLALLNVLTHFIENGKSRQWARDHFLHLPTLLRACEVQQQLLERLRQLKRPIVSCGAKGLDRVRQCVASGFCLLSARRSSTNWSAYRPMLNAGVTCYVHPSSAVYARAEMPLYVVYHDLLLTTREYLVIVTAVEPEWLVEASRGVFIVKGSPKGLVTSAATPSGTAVVENRSVTGRVVSETLQNPSPIPQGLSVPRPPVHQPKSKGGMVLTRRRNNI
Protein: LRR receptor-like serine/threonine-protein kinase ERL2 (EC 2.7.11.1) (Protein ERECTA-like kinase 2) (Q6XAT2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor kinase that regulates inflorescence architecture and organ shape as well as stomatal patterning, including density and clustering, together with ERL1 and ER.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Protein EPIDERMAL PATTERNING FACTOR 2
- Protein EPIDERMAL PATTERNING FACTOR 1
- EPIDERMAL PATTERNING FACTOR-like protein 4
- LRR receptor-like serine/threonine-protein kinase ERL1
- Mitogen-activated protein kinase kinase kinase YODA
- LRR receptor-like serine/threonine-protein kinase ERECTA
- EPIDERMAL PATTERNING FACTOR-like protein 9
- Transcription factor SPEECHLESS
- EPIDERMAL PATTERNING FACTOR-like protein 6
- Transcription factor MUTE
Sequence:
MRRIETMKGLFFCLGMVVFMLLGSVSPMNNEGKALMAIKASFSNVANMLLDWDDVHNHDFCSWRGVFCDNVSLNVVSLNLSNLNLGGEISSALGDLMNLQSIDLQGNKLGGQIPDEIGNCVSLAYVDFSTNLLFGDIPFSISKLKQLEFLNLKNNQLTGPIPATLTQIPNLKTLDLARNQLTGEIPRLLYWNEVLQYLGLRGNMLTGTLSPDMCQLTGLWYFDVRGNNLTGTIPESIGNCTSFEILDVSYNQITGVIPYNIGFLQVATLSLQGNKLTGRIPEVIGLMQALAVLDLSDNELTGPIPPILGNLSFTGKLYLHGNKLTGQIPPELGNMSRLSYLQLNDNELVGKIPPELGKLEQLFELNLANNNLVGLIPSNISSCAALNQFNVHGNFLSGAVPLEFRNLGSLTYLNLSSNSFKGKIPAELGHIINLDTLDLSGNNFSGSIPLTLGDLEHLLILNLSRNHLNGTLPAEFGNLRSIQIIDVSFNFLAGVIPTELGQLQNINSLILNNNKIHGKIPDQLTNCFSLANLNISFNNLSGIIPPMKNFTRFSPASFFGNPFLCGNWVGSICGPSLPKSQVFTRVAVICMVLGFITLICMIFIAVYKSKQQKPVLKGSSKQPEGSTKLVILHMDMAIHTFDDIMRVTENLDEKYIIGYGASSTVYKCTSKTSRPIAIKRIYNQYPSNFREFETELETIGSIRHRNIVSLHGYALSPFGNLLFYDYMENGSLWDLLHGPGKKVKLDWETRLKIAVGAAQGLAYLHHDCTPRIIHRDIKSSNILLDGNFEARLSDFGIAKSIPATKTYASTYVLGTIGYIDPEYARTSRLNEKSDIYSFGIVLLELLTGKKAVDNEANLHQMILSKADDNTVMEAVDAEVSVTCMDSGHIKKTFQLALLCTKRNPLERPTMQEVSRVLLSLVPSPPPKKLPSPAKVQEGEERRESHSSDTTTPQWFVQFREDISKSSL
Protein: Mannose-1-phosphate guanyltransferase (EC 2.7.7.13) (ATP-mannose-1-phosphate guanylyltransferase) (GDP-mannose pyrophosphorylase) (NDP-hexose pyrophosphorylase) (P41940)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9195935}.
Interaction partners:
- Phosphomannomutase
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- Dolichol-phosphate mannosyltransferase
- Mannose-6-phosphate isomerase
- Chromatin structure-remodeling complex protein RSC8
- SWI/SNF complex subunit SWI3
- Glucose-6-phosphate isomerase
- Translation initiation factor eIF2B subunit beta
- Phosphoacetylglucosamine mutase
- Translation initiation factor eIF2B subunit delta
Sequence:
MKGLILVGGYGTRLRPLTLTVPKPLVEFGNRPMILHQIEALANAGVTDIVLAVNYRPEVMVETLKKYEKEYGVNITFSVETEPLGTAGPLKLAEDVLKKDNSPFFVLNSDVICEYPFKELADFHKAHGGKGTIVATKVDEPSKYGVIVHDIATPNLIDRFVEKPKEFVGNRINAGLYILNPEVIDLIEMKPTSIEKETFPILVEEKQLYSFDLEGFWMDVGQPKDFLSGTVLYLNSLAKRQPKKLATGANIVGNALIDPTAKISSTAKIGPDVVIGPNVTIGDGVRITRSVVLCNSTIKNHSLVKSTIVGWNSTVGQWCRLEGVTVLGDDVEVKDEIYINGGKVLPHKSISDNVPKEAIIM
Protein: Monopolin complex subunit LRS4 (Loss of rDNA silencing protein 4) (Q04087)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing.
Subcellular location: Nucleus, nucleolus. Chromosome, centromere. Note=Transiently released from the nucleolus and localized to the centromere regions during late pachytene. This relocation is CDC5 dependent.
Interaction partners:
- Monopolin complex subunit CSM1
- Monopolin complex subunit MAM1
- Casein kinase I homolog HRR25
- Inner nuclear membrane protein SRC1
- Topoisomerase 1-associated factor 2
- Nuclear rim protein 1
- Tyrosine-protein phosphatase CDC14
- NAD-dependent histone deacetylase SIR2
- Nucleolar protein NET1
- DNA replication fork-blocking protein FOB1
Sequence:
MTTLLQLLSNYYKAKLDSERIYNEYVQSQYEFASLDKLNNNKGDPKKVVDETLFLQRQIAQLNKQLQLSFQENEKLLSVQKNQKALYQSKLSSKDAFIDDLKLKLKVEQISVDKHNKERTPSTGRDEQQRNSKAAHTSKPTIHLLSPIVNRDKPNNQTNDRGGNDPDSPTSQRRSRGLRSLLSSGKNTIFDSISKNLDDEINENAHIRNDTTSSKIAGKSPSRLSALQKSPELRKERNNMILKEHILRSKDDQNITSSRKLDNIELSSIGDSTAMTSRSSTVNANDILGNEENDGITKLKRVNKLTSSPVKRDCSTNKKRKLTKQRIATLPNSDEELSNNLNVDEFV
Protein: Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form] (Q91X17)
Organism: Mus musculus (Mouse)
Function: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.
Subcellular location: [Uromodulin, secreted form]: Secreted {ECO:0000269|PubMed:26673890}. Note=Detected in urine. {ECO:0000269|PubMed:26673890}.; SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:26673890}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P07911}. Basolateral cell membrane {ECO:0000250|UniProtKB:P07911}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P07911}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:P07911}. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization. Secreted into urine after cleavage. Colocalizes with NPHP1 and KIF3A. {ECO:0000250|UniProtKB:P07911}.
Interaction partners:
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Aquaporin-2
- Sodium-dependent phosphate transport protein 2A
- Tumor necrosis factor
- Beta-1,4 N-acetylgalactosaminyltransferase 2
- ATP-sensitive inward rectifier potassium channel 1
- Kidney androgen-regulated protein
- Solute carrier family 12 member 3
- Pancreatic polypeptide prohormone
Sequence:
MGIPLTWMLLVMMVTSWFTLAEASNSTEARRCSECHNNATCTVDGVVTTCSCQTGFTGDGLVCEDMDECATPWTHNCSNSSCVNTPGSFKCSCQDGFRLTPELSCTDVDECSEQGLSNCHALATCVNTEGDYLCVCPEGFTGDGWYCECSPGSCEPGLDCLPQGPDGKLVCQDPCNTYETLTEYWRSTEYGVGYSCDAGLHGWYRFTGQGGVRMAETCVPVLRCNTAAPMWLNGSHPSSSEGIVSRTACAHWSDQCCRWSTEIQVKACPGGFYIYNLTAPPECNLAYCTDPSSVEGTCEECRVDEDCISDNGRWRCQCKQDSNITDVSQLEYRLECGANDIKMSLRKCQLQSLGFMNVFMYLNDRQCSGFSESDERDWMSIVTPARNGPCGTVLRRNETHATYSNTLYLANAIIIRDIIIRMNFECSYPLDMKVSLKTSLQPMVSALNISLGGTGKFTVRMALFQSPTYTQPHQGPSVMLSTEAFLYVGTMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCPRTEDTTIQVTENGESSQARFSVQMFRFAGNYDLVYLHCEVYLCDSTSEQCKPTCSGTRFRSGNFIDQTRVLNLGPITRQGVQASVSKAASSNLRLLSIWLLLFPSATLIFMVQ
Protein: Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] (P29466)
Organism: Homo sapiens (Human)
Function: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20197547}. Cell membrane {ECO:0000269|PubMed:20197547}.
Interaction partners:
- Apoptosis-associated speck-like protein containing a CARD
- Pyrin
- Interferon-inducible protein AIM2
- NLR family CARD domain-containing protein 4
- NACHT, LRR and PYD domains-containing protein 3
- Interleukin-1 beta
- Caspase-8
- Gasdermin-D
- NACHT, LRR and PYD domains-containing protein 6
- NACHT, LRR and PYD domains-containing protein 1
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Protein: Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform (AtB' eta) (PP2A, B' subunit, eta isoform) (Q9LU89)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). The holoenzyme composed of PP2AA1, PP2A4 and B'ETA acts as negative regulator of plant innate immunity by controlling BAK1 phosphorylation state and activation in surface-localized immune receptor complexes. Required for the formation of the PP2A holoenzyme that negatively regulates brassinosteroid signaling by dephosphorylating and inactivating BRI1 in the cytoplasm.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:19672620}. Cytoplasm {ECO:0000269|PubMed:26517938}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''epsilon
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''gamma
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''delta
- Serine/threonine protein phosphatase 2A regulatory subunit B''alpha
- Serine/threonine protein phosphatase 2A regulatory subunit B''beta
Sequence:
MWKQILSKLPNKKSSKHEHRGREHGGHSSSSSHTSGASTSKSTDNGAAKSHAKNASPAGKSAASDSGFKDGNLKSSGNNNNNNNNGVFTPYEALPSFKDVPNTEKQNLFIKKLNLCRVVFDFTDPTKNIKEKDIKRQTLLELVDYVNSPNGKFSEVGIQEVVRMVSANIFRTLNPQPRENKVIDALDLEEEEPSMDLAWPHLQLVYELFLRFVASPETDTKLAKRYIDQSFVLRLLDLFDSEDPRERDCLKTILHRIYGKFMVHRPFIRKSINNIFYRFVFETEKHNGIAEFLEILGSIINGFALPLKDEHKVFLVRVLIPLHKPKCLQMYHQQLSYCITQFVEKDCKLADTVIRGLLKYWPVTNSSKEVMFLNELEEVLEATQPPEFQRCMVPLFRQIARCLNSLHFQVAERALFLWNNNHIENLIMQNRKVILPIIFPALERNAQKHWNQAVHSLTLNVRKIFHDLDPELFKECLAKFKEDESKAAETEAKREATWKRLEELGVRKAS
Protein: Intraflagellar transport protein 122 homolog (Abnormal dauer formation protein 10) (G5EFW7)
Organism: Caenorhabditis elegans
Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Plays a role in chemotaxis and sensory perception. Required for entry into and exit from the dauer larval stage and this may be mediated by daf-12, daf-16 and daf-41. Controls the behavioral response, namely the avoidance response, and pathogen-responsive gene expression in the response to pathogenic bacteria such as E.coli and P. aeruginosa.
Subcellular location: Cell projection, cilium {ECO:0000305|PubMed:11301258}. Note=Shuttles at the same rate as intraflagellar transport (IFT) complex B proteins such as osm-1, osm-5 and osm-6 along the cilia of the amphid and phasmid sensory neurons. {ECO:0000269|PubMed:11301258}.
Interaction partners:
- WD repeat-containing protein dyf-2
- WD_REPEATS_REGION domain-containing protein
- Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
- Tetratricopeptide repeat protein 21 homolog
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein osm-1
- Intraflagellar transport protein che-13
- Intraflagellar transport protein 46 homolog
- CHE-2 protein
- Intraflagellar transport protein 52 C-terminal domain-containing protein
Sequence:
MRPNLLWVDKILDENNEAGVCIYDLAFKPDGSELLLAADNKVYLFDVNEGGQMQTLKGHKDLVYTVAWSHNGELFASGGADKLVILWNEKHEGTLRYSHTDVIQCMMFNPCNQILLTCALNEFGLWSTADKNVIKQRSVVRCCSCAWNTDGTIFAIGHGDGTITLRKGTNATEEPSIIIQRDNEPIWGIAFSSNRTFASRDSQGNPMGIDEIMAVIDWNKTLSFYSLDGTFIESKNLEFEPHCISYCLNGEYLLIGGSDKILKIYTRKGVLLGTVAQMDHWIWSVTVRPNSQTVAMGCVDGTIACYNLVFSTVHCVDHARYANRKSMTDVFVQNLEYRTSSNICCHDLVKKMSLYDTKLAVQLSDKIQIYKQTGGVSKNERRKQLKYTLQDTIRKDLSFSLMVVTHGHLVVCNDEKLECYDFKGIKKRSWNMKSIVRYLRVLGGPAHRETLVLGTTDGGVYKVFIDNDYPILLDSRKTAIKCIDINANRTVLASIEDTLVCKWSDIATGETLLQEPGCYSVVFNTVNENLFAFTTNNMLHVRTLAAPGHTTRGVGYVLGFVKNRTFCLVQYNLIPLEVPYTIHLYQYIERGDFKEALRIACLGVVKNDWKYLANKALDALEFDVARKAYKRVRDRKMLRMVWELKKMKSNGEPDAILRATILAYTKKFREAAKIFKENGFENRAMELFTDMRMFDDVQEVMTTASGETKKMLMRKRASWARDANQPKIAAEMLISSGDLDKAALLIIDNDWLELAIEISHKIDRSDLETMKKLSAYFIRKHEFGLASRIFQSINDMKSIVDMHVNAGHWTDAFAIADRHPKYVEDVYLPYARFLAERDRFEEAQKAFHRAGKEQEAMHVLEQLTSNSVNENRFADAGFYYWLLSQQYLDRSQTEENLTLLNKAKEAASLADAYYAYYPVFIFCSQPFSFERNENILNMARYLTFTPYIDNISKVFVYFTIAKIANEMGAYKSARTALDQLTNLRVLPQFELDGQIEVMTLNIRAKPFTDVESMQPMCYRCGLNNPLLGGMSCIHCETPFIISFVSFDILPLIEFKIENDISFDEAKELIESEPPLSDDDYNPLRGLKKGIKEIILNRESLSKLEQGHVIIQTFPPPLAPKFLFNVMPSITIAQCKGCNKVFDLDDFEMACLRKGHCPFCRTSYDRNEAFFVDEEEDEDNTNIPSFGQFSRFS
Protein: Remorin 4.2 (AtREM4.2) (Remorin group 4 member 2) (P93758)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Collaborates with REM4.1 to positively regulate the BCTV and BSCTV susceptibility.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25289013}.
Interaction partners:
- Thylakoid lumenal P17.1 protein
- ADP-glucose phosphorylase
- NAD
- Alcohol dehydrogenase-like protein
- Alcohol dehydrogenase-like protein
- TORTIFOLIA1-like protein 3
- S-protein homolog
- F16N3.9 protein
- BAHD acyltransferase At5g47980
- Putative U-box domain-containing protein 42
Sequence:
MLTLYHQERSPDATSNDRDETPETVVREVHALTPAPEDNSRTMTATLPPPPAFRGYFSPPRSATTMSEGENFTTISREFNALVIAGSSMENNELMTRDVTQREDERQDELMRIHEDTDHEEETNPLAIVPDQYPGSGLDPGSDNGPGQSRVGSTVQRVKREEVEAKITAWQTAKLAKINNRFKREDAVINGWFNEQVNKANSWMKKIERKLEERKAKAMEKTQNNVAKAQRKAEERRATAEAKRGTEVAKVVEVANLMRALGRPPAKRSFFSFS