wanglab/gogpt-training-data huggingface dataset:
Protein: ATP-binding cassette transporter abc4 (ABC transporter abc4) (EC 7.6.2.2) (ATP-energized glutathione S-conjugate pump abc4) (Glutathione S-conjugate-transporting ATPase abc4) (Q9P7V2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in detoxification of xenobiotics, and vacuolar sequestration of glutathione S-conjugates. Together with abc2, required for accumulation of a red pigment (ade pigment) in the vacuole of a mutant affected in the adenine biosynthetic pathway.
Subcellular location: Vacuole membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:16849797}.
Interaction partners:
- ATP-binding cassette transporter abc1
Sequence:
MENFHHRPFKGGFGVGRVPTSLYYSLSDFSLSAISIFPTHYDQPYLNEAPSWYKYSLESGLVCLYLYLIYRWITRSFTVKQTVGSEFSGLRKAHGILLWLLSILFLGMTAFMFVNDAFPTAFSDPPVKICLLAYSVHLFLLHSLRMIYPRARPTLYHAAVLLNLLLLPPIFHFYSYPFFFVDHPPLSSYSPFLWFYFFITIVGNFIPLFTPRVWYPLFPEDNYQPSAEQVCSMFNFACSYGYLNPLVLTAKRRVVEVDDTPVIPDYDKNKAWTYRFERMKTPSLFITIHKIFWRQILGMGVSSFMVSVCQFLSPIALNRLLKHLESPSSSSVNPLVWIVLLLTGPFLTSLFTQFYLFMSTRYLARSYTTLVQQIYNKVIRSRFVQNKSGDSKVGRSNNLISTDVDDIGEIREFIHIIVRAPVEIAGSIYLLQKLLGWSAYVGLALTVLTCSVPIVLGPLVAKLTLRANRATDSRIELMSELLQSIRITKFFGWELPMLDRVKQRRQVELNRTWKLLLMEICIQVLVESLPVFSMFATFVVFTTIMGQTITPSIAFTSISLFSFIRTQFSWIAYLMRQIVQIFVSIGRVSDFLNDPDEVDPVNTIEDTSQEIGFFNASLTWVSNPSPGDFCLRDLNIVFPRNKLSIVIGPTGSGKSSLISALLGELSLNKGSYNLPRSKGVSYVSQVPWLRNATIRDNILFDYPYIEERYKKVIQACGLLTDLQSFVASDLTEIGEKGVTLSGGQKQRIALARAVYSPTSIVLMDDVFSALDIHTSNWIYKHCFQSSLMENRTVILVTHNVHLFMDSAAFIVTVKNGSAFPVTDKSSPLLFLAEQAASASEAAAPDLAAIPIPNEVDDAEAADEKDGKLVEEEQRVTGDVVFSEIFSYMKHFGSGFYVAAVLLFFVTTQATSILIDLWVAFWTNSSVNSPDVNNNKFLFVYGTMLLAYSLLDFLRTVSYDRGAWWASRKLHDSMLESVFGTFASWFDKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLSVAGGILSVSSAMPIFMIPAVIVCLAGYYFGLLYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAFNRQTIFKQMFSERLDNLVRLQSTSYNLNRWVAVRTDGISGLVGAIAGLIALLQKDLSPGVVGFSLNQAVIFSSSVLLFVRSCNSLQAEMNSYERVLEYSKLPQEPAPTIAGQVPATWPKEGDIVFNHVSVSYSAAGPTILKDVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNLNALRQRISFIPQDPILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQKPIHITLDTHVASEGSNFSQGQKQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAHRLKTIVDYDKVMVLDKGVLVEYGPPAVLYHNNGHFRRMCDGSGITFLPPETRGSKSA
Protein: Signal transducer and activator of transcription (Q9JIA0)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
Sequence:
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQRFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASTDAGASATYMDQAPSPVVCPQPHYNMYPPNPDPVLDQDGEFDLDESMDVARHVEELLRRPMDSLDARLSPPAGLFTSARSSLS
Protein: Ebony protein (O76858)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGSLPQLSIVKGLQQDFVPRALHRIFEEQQLRHADKVALIYQPSTTGQGMAPSQSSYRQMNERANRAARLLVAETHGRFLQPNSDGDFIVAVCMQPSEGLVTTLLAIWKAGGAYLPIDPSFPANRIHHILLEAKPTLVIRDDDIDAGRFQGTPTLSTTELYAKSLQLAGSNLLSEEMLRGGNDHTAIVLYTSGSTGVPKGVRLPHESILNRLQWQWATFPYTANEAVSVFKTALTFVDSIAELWGPLMCGLAILVVPKAVTKDPQRLVALLERYKIRRLVLVPTLLRSLLMYLKMEGGGAAQKLLYNLQIWVCSGEPLSVSLASSFFDYFDEGVHRLYNFYGSTEVLGDVTYFACESKKQLSLYDNVPIGIPLSNTVVYLLDADYRPVKNGEIGEIFASGLNLAAGYVNGRDPERFLENPLAVEKKYARLYRTGDYGSLKNGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAELPLVDKAIVLCYHAGQVDQAILAFVKLRDDAPMVTETQMEARLKDKLADYMTPQVVILEHVPLLVNGKVDRQALLKTYETANNNEGDSSIVLDFDYSQVPEDLKLTARDLFETVGGVIGRSTETTLPPHSNFYELGGNSLNSIFTVTLLREKGYNIGISEFIAAKNLGEIIEKMAANHDAVQLEEESLNACPHLKMEAVPLRLEHRQEVIDIIVASFYNKADLEQWLKPGVLRTDYSDILNDIWNVLVERDLSFVVYDTNTDRIIGTALNFDARNEPEVDIKSKLLIVFEFLEFCEGPIRDNYLPKGLNQILHSFMMGTAEKLNPRENIACMHFMEHEVLRVAREKQFAGIFTTNTSPLTQQLADVYHYKTLLNFQVNEYVHSDGSRPFGDAPDEQRAIVHWKEVGK
Protein: Voltage-dependent anion-selective channel (Q586M2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- Gamma-tubulin complex subunit, putative
Sequence:
MFAPAKSLVLYKDYHKDAKDLLTKNYSSAQKWKLESKFKGPKDKLILNPTVTSDGAFSTDLEYTISQCGAALKGTYATSTSNVTGTVTYHYKGHKIEGVVNKNGNYEVSHEGNFQGLLSLHEKLTKKTLEVGAGTAIGPYCSVGCGALYNLGAKGNCDWTASCRYARCGYTAAVRTNKLNTYTTSITARVPKCPHRVVVGAEVVCGRGQPWTGVVGVEADCVLVKGNVLKARVNKKLEWAAVYIAKLIDNWTVAVTVDKSLKPGVLITHS
Protein: Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) (P21452)
Organism: Homo sapiens (Human)
Function: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Protachykinin-1
- Tachykinin-3
- Tachykinin-4
- Choline/ethanolamine kinase
- Guanine nucleotide-binding protein G
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
Protein: Fatty acid binding protein 1-B.1 (Fatty acid binding protein 1b) (Zf-FABP1b) (Q4VBT1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P07148}.
Interaction partners:
- Fatty acid-binding protein 2, intestinal
- Brain-type fatty acid-binding protein b
- Adipocyte fatty acid-binding protein
- Fatty acid binding protein 11a
- Fatty acid-binding protein 3, muscle and heart
- Brain-type fatty acid-binding protein
- Gastrotropin
- Fatty acid binding protein 1-A, liver
- Apolipoprotein A-IV b, tandem duplicate 2
- Apolipoprotein A-IV b, tandem duplicate 2
Sequence:
MSFTGKYQLESQEGFVEFMKAVGLPDDMIEKGKDIKSVSEIEENGNQFKVTVTTGSKVLTNSFTIGQEADIETLTGERVKTIVNREGNKLKVVLNRITSITELVDANTLVNTLTLGGLVYKRISKRVA
Protein: Possible conserved membrane protein (O69661)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized membrane protein Rv3691
- Probable conserved membrane protein
- Probable methanol dehydrogenase transcriptional regulatory protein MoxR2
- Probable conserved transmembrane protein
- Possible conserved transmembrane protein
- Possible conserved membrane protein
- Phosphoribosylamine--glycine ligase
- Histidine N-alpha-methyltransferase
- KANL3/Tex30 alpha/beta hydrolase-like domain-containing protein
Sequence:
MILTGRTGLLALICVLPIALSPWPARAFVMLLVALAVAVTVDTLLAASTRKLRFTRSPYTSARLGQPVDASLLLCNGGRRRFRGQVRDAWPPSARAQPHTHDVDVAAGQRQQVHTALRPVRRGDQRAAMVTARSIGPLGLAGRQSSQSVPGLVRVLPPFLSRKHLPSRLAKLREIDGLLPTLIRGQGTEFDSLREYVVGDDVRSIDWRASARRADVMVRTWRPERDRRVVIVLDTGRMAAGRVGVDPTAADPAGWPRLDWSMDAALLLAALASRAGDHVDFLAHDRISRAGVFGASRSELLAQLVDAMAPLRPALIESDWHAMIATILRRTRRRSLVVLLTDLNATALDEGLLPVLPQLSARHHVLVAAVADPRVDQLAAGRSDAAAVYDAAAAERARNDRRAIASQLRRGGVDVIDAPPAEIAPGLADRYLAMKATGRL
Protein: Stage II sporulation protein E (EC 3.1.3.16) (Stage II sporulation protein H) (P37475)
Organism: Bacillus subtilis (strain 168)
Function: Normally needed for pro-sigma E processing during sporulation but can be bypassed in vegetative cells. Activates SpoIIAA by dephosphorylation.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Polar septum.
Interaction partners:
- Anti-sigma F factor
- Sporulation sigma-E factor-processing peptidase
- Anti-sigma F factor antagonist
- Serine/threonine-protein kinase YabT
- Uncharacterized protein YabS
- Stage II sporulation protein R
- Stage 0 sporulation protein A
- RNA polymerase sigma-F factor
- Stage II sporulation protein Q
- Cell division protein FtsZ
Sequence:
MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGFIYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLLILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAIVEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQAEHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKEGKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPGTVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLSKITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSKQVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQEEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQILVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAAAISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDLSIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDLLIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMTVVVVRIDHNTPKWASIPVPAIFQNKQEIS
Protein: Histone H2B (Q867U7)
Organism: Trypanosoma brucei brucei
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000451}.
Interaction partners:
Sequence:
MPPTKGGKRPLPLGGKGKGKRPPGQTTKSSSSRKKSGARRGKKQQRWDLYIHRTLRQVYKRGTLSKAAVRVLSSFIEDMYGKIQAEAVHVACINNVKTLTAREIQTSARLLLPPELAKHAMSEGTKAVAKYNASREEAYSKVL
Protein: Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) (P36972)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Subcellular location: Cytoplasm.
Interaction partners:
- Adenylosuccinate lyase
- GMP synthase
- Adenosine kinase
- Purine nucleoside phosphorylase
- Bifunctional purine biosynthesis protein ATIC
- Inosine triphosphate pyrophosphatase
- AMP deaminase 1
- AMP deaminase 3
- AMP deaminase 2
- Adenylate kinase 9
Sequence:
MSESELQLVARRIRSFPDFPIPGVLFRDISPLLKDPDSFRASIRLLAGHLKSTHGGKIDYIAGLDSRGFLFGPSLAQELGVGCVLIRKRGKLPGPTVSASYSLEYGKAELEIQKDALEPGQKVVIVDDLLATGGTMCAACELLSQLRAEVVECVSLVELTSLKGREKLGPVPFFSLLQYE
Protein: GH27912p (Q8T0I6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDPLSANYGNGGINSSMHPSTGATAKKSIKDAHSFLGENSALVNLDNLIKPIAPQTQTGNQPAYNPFSDNVVPPKTNLFQQQQPAVPSINQLKQQAPFSVSMNQDPWAPVMGGVSTTSQPKLPPPVRPTSLNLGPSSVGEFQLLSALSNPIIPIAHIPQPQPNLQVYNNAYQSSSSTNILGKSNIPTNMNSSTSNSTIHSCYASPSPGVDGIRNMDIFTERPYYNSPTAPADDTYMYNSRDNNNINSNYGTPSLYSSFAASYSSALSDSLAETPGISVAPLGFVADTVMSFGPSSSSANCKLEQNNNMPWIKPEAATNPFLS
Protein: Chromodomain helicase DNA binding protein 1 like (A0A494C179)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MERAGATSRGGQAPGFLLRLHTEGRAEAARVQEQDLRQWGLTGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMIIEGGHFTLGAQKPAADADLQLSEILKFGLDKLLASEGSTMDEIDLESILGETKDGQWVSDALPAAEGGSRDQEEGKNHMYLFEGKDYSKEPSKEDRKSFEQLVNLQKTLLEKASQEGRSLRNKGSVLIPGLVEGSTKRKRVLSPEELEDRQKKRQEAAAKRRRLIEEKKRQKEEAEHKKKMAWWESNNYQSFCLPSEESEPEDLENGEESSAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGRGGLFTALEKRSAEPRKIYELAGKMKDLSLGGVLLFPVDDKESRNKGQDLLALIVAQHRDRSNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLIRKHLAARGIPTYIYYFPRSKSAVLHSQSSSSSSRQLVP
Protein: Phospholipase A2 (EC 3.1.1.4) (Group IB phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 1B) (P86043)
Organism: Struthio camelus (Common ostrich)
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
AVWQFREMIKCTIPPSDDLLDF
Protein: Uncharacterized protein DDB_G0273449/DDB_G0273577 (Q557G4)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Glutamine-dependent NAD
- GTP cyclohydrolase 1
- Nicotinate phosphoribosyltransferase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Sequence:
MKFIYSIFIIIQIIFFINLINGQIVRGPDLQLGYVENGTMLLGSPNVVNIGDQNFMNTKDLSNSSWTDHRYNRYDWSFIRFHIRNNQSGFEATADFHPRVDEFSTIKFSANGLIQYLNETNKNRNVFKNREVEGYTVWAEIPYSKNVTSFTSRLVDVPCQETLTNGSVVVSTDKACQNVTDITTATYQKVENYNSTVLEPIILPPKHIFEFSTRTFVSYFTIIFQLDNGAIVDAVWDGDRDTSICKNCDSCIDNQCATKFDDMRCDEGVGCQLKFFLAWAGVDKSGKNCVSLNKIPSKFQKYSATAIKNMGTGLVSDFFYKINDNNNNPNTA
Protein: Pore membrane protein of 33 kDa (Q12164)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Contributes to proper distribution and/or efficient assembly of nuclear pores. Required for normal pore density in the daughter nucleus during telophase.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus, nuclear pore complex.
Interaction partners:
- Reticulon-like protein 1
- Nucleoporin POM34
- Nucleoporin POM152
- Protein SEY1
- Nucleoporin NUP133
- Nucleoporin NUP188
- Nucleoporin ASM4
- Inner nuclear membrane protein HEH2
- Protein YOP1
- Nucleoporin NUP170
Sequence:
MSSRPANNQGPPNLPARDKSLVQRFMAVAKSLQFAWFTGHSVVLISSILYLLKMSEFYYRSAYLGVIESFGIIIYQQFFTRNEPLQTQDAAATKASIKSRVAGLLKSEDVLYLVLANFWLFTPRFSFSLIPFFAFAVFHVLIYVEKVLLPKVFHLSSKDSSKILSFIDKFVVQYNDLCMHWVGTAELLIFILVLFRAILCFQRSWIILVVYAIFIKLRYENSKYMKAAFAQWRVRMDGIISHPSIPPFVKRAYNAIKMSLIRLSEYRLSGAPQVTKKQN
Protein: Exonuclease V (X6RCL8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAETREEETVSAEASGFSDLSDSEFLEFLDLEDAQESKALVNMPGPSSESLGKDDKPISLQNWKRGLDILSPMERFHLKYLYVTDLATQNWCELQTAYGKELPGFLAPEKAAVLDTGASIHLARELELHDLVTVPVTTKEDAWAIKFLNILLLIPTLQSEGHIREFPVFGEGEGVLLVGVIDELHYTAKGELELAELKTRRRPMLPLEAQKKKDCFQVSLYKYI
Protein: Tyrosine-protein kinase hopscotch (EC 2.7.10.2) (Q24592)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair-rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation.
Subcellular location: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Wholly intracellular, possibly membrane associated. {ECO:0000250}.
Interaction partners:
- Cytokine receptor
- Signal transducer and transcription activator
- Outstretched
- Lnk, isoform D
- FI03911p
- Suppressor of cytokine signaling at 36E, isoform D
- Unpaired 2
- Insulin receptor substrate 1
- Tyrosine-protein phosphatase non-receptor type 61F
- Tyrosine-protein kinase Src64B
Sequence:
MALANGGEDRMDDSSSGRTSLADSASLTNSSLRSGTSSQSIHTNDGTIRVFNFTTGEFERFHPNMLCEEICNTMCRQLGIAPIAQLLYGIREHSTSRRPSPLVRLDLTWCLPGERLNCQLVYCFRMRFRVPELDSQLELIDGRSHKFLYRQMRYDMRTEQIPEIRYPEHKDKSTGLAVMDMLIDDQEQSEDQQAMRSIEKLYKLYLPPSLWRAHSFFVGSKIREVFRSLKANSLSVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGSTNTLSTLTTNTNSVALGGSGKKAKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLKWILVGAVEGIFMISKINDTSVRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSLHCHGPIGGAYSLMKLHENGDKCGSYIVRECDREYNIYYIDINTKIMAKKTDQERCKTETFRIVRKDSQWKLSYNNGEHVLNSLHEVAHIIQADSPDRYRIPASKYDKPPLLLLLLPKNLKAKKTDLQLSEAELQRRNPQIFNPRTDLQWYPDSISLSDDGMMFTMRGDWIQQSPVKDVSVTMKMLKSDGNFMEFFRLAQTWSLIQSPQFLKLYGLTLADPYTMVMEYSRYGPLNKFLHSMPNVTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTDFHREIGIMRTLSHPNIVKFKYWAEKSHCIIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDIITREVATKVTHPTDGHQSPPNQPTDAE
Protein: Probable serine/threonine-protein kinase RTK1 (EC 2.7.11.1) (Ribosome biogenesis and tRNA synthetase-associated kinase 1) (Q12100)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable serine/threonine-protein kinase that may be involved in ribosome biogenesis.
Interaction partners:
- Uncharacterized membrane protein YGR016W
- Putative mitochondrial carrier protein PET8
- Uncharacterized protein YDR239C
- Protein AIM2
- Putative oxidoreductase TDA3
- CCR4-NOT transcriptional complex subunit CAF120
Sequence:
MVKETPLHSSSSTSLSSLFRPTKLKNLSAKIFNGGGNQSYSKTDDVSRSSSRSSKKNTDSDQEDQIKYNKPNDRRSTIGKSPQGNGALSKESHVVASSTLTGISPTSAKKAPIDYSPSRPLPNNHNPVRTGHTVPHLPHSIHNPINYIHQGSKDAFHHPHPVRSTAHSNISTVSSAKSDTPSSNLSYQAHMHPVEILQKQIEDKHFMDSQASTPGSVELQHNSSSGSDDTSSRKKKSLRLTRFFKKIHNDYHDNHHHHHHHNRGSTPTKPKLNLNTNENIVESNGKALYETDNPVELLEKYGIPGRKLGEGASGSVSVVERTDGKLFACKMFRKPHLNNEGTNQSQLANYSKKVTTEFCIGSTLHHENIVETLDMLTEGDTYLLVMEYAPYDFFNLVMSNLMTQDEVNCYFKQLCHGVNYLHSMGLAHRDLKLDNCVVTKDGILKLIDFGSAVVFQYPYEDTIVKSHGIVGSDPYLAPELLKQTSYDPRVADVWSIAIIFYCMVLKRFPWKAPKKSFNSFRLFTEEPEDEDDIVRGPNKILRLLPRHSRTIIGRMLALEPKQRVLMNDVVKDDWLVSVPSCEVDPTSGDLVEKPKNHKHHLVTEEELNELTKQHGNKDSN
Protein: Titin (Q9JHQ1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
EAFPEDEGTYAFVANNAVGQVSSTATLRLEAPESILHEQIGQQIEMEMKAAPVIKRRIEPLEVALGHLAKFTFEIQGAPNVRFQWFKAGREIYESDKCSIRSSNYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFLCTVSGTPVIETIWQKDGTALSPSPDCRITDADNKHSLELSNLTVQDRGVYSCKASNKFGADICQAELTIIDKPHFIKELEPVQSAINKKIHLECQVDEDRKVSITWSKDGQKLPAGKDYKIYFEDKIASLEIPLAKLKDSGTYSCTASNEAGSSSSSATVAVREPPSFVKEGGXLLFNAPGRISAPPLQAERLTC
Protein: Troponin T, skeletal muscle (K8ERV5)
Organism: Caenorhabditis elegans
Interaction partners:
- EF-hand domain-containing protein
- Troponin I 3
- Troponin I 4
- Troponin I 2
- Tropomyosin isoforms a/b/d/f
- Troponin I 1
- Alpha-actinin, sarcomeric
- Myosin-1
- Myosin, essential light chain
- Myosin regulatory light chain
Sequence:
MSDEEYSEYEDEEVEEEEVEEVEEAEAEEEEDTEQQEEERFKRASVDTTATGGPATPAASSHAPVSFDGEALNEGEKAMLAAKRRHENDEQAKLEDYEKARRSEREKEEEELEKLKEKQAQRKLAREQEEREAAERKRLDEERRQKEEQERRARAEEEKKRKEEEKLKKAQMMGGGFPGQQGGRNFVIQKKEESAGVGDRFGNIVQAKQEMGMTKEQQEEAKSVAMAGIRKSIAEASTILPNDMKAKIKELHQRICKLEAQKYDLEKRHERQEYDLKELNERSRQVARANNAKNGQVSGDDTGGRHPPKVQISSKYDRQIDRRNFKERRQVYENKIAFPCFPGVAPPPALYEKVIKKMDYEIQQELEAAEEEEDY
Protein: Photosystem II reaction center protein I (PSII-I) (PSII 4.8 kDa protein) (Q6ENJ3)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01316}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01316}.
Interaction partners:
- Photosystem II reaction center protein J
- Photosystem II reaction center protein T
- Photosystem II reaction center protein L
- Cytochrome b559 subunit beta
- Photosystem II reaction center protein H
- Photosystem II reaction center protein K
- Cytochrome b559 subunit alpha
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein Z
- Photosystem II CP47 reaction center protein
Sequence:
MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGRDE
Protein: Cytochrome c oxidase subunit 8A, mitochondrial (Cytochrome c oxidase polypeptide VIII-liver/heart) (Cytochrome c oxidase subunit 8-2) (P10176)
Organism: Homo sapiens (Human)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
Interaction partners:
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome c oxidase subunit 6A1, mitochondrial
- Cytochrome c oxidase subunit 6C
- Cytochrome c oxidase subunit 6B1
- Cytochrome c oxidase subunit 7B, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit NDUFA4
Sequence:
MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILSHLETYRRPE
Protein: [histone H3]-lysine(4) N-trimethyltransferase (EC 2.1.1.354) (Q32LV8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MEAVIMERFISEGKGNGLRALREIKPGEVIYSCEPFAFCVARDFLKTACQSCLKRGESLSRCSQCKTARYCNVQCQKQAWPDHKRECKCLKHLQPRIPTDSVRLVARIIFKLLSQSESDQEELYSIAEHQSHLADMSEEKTEGLKHLCTTLQVYLAEENCDLSRLPSGLDPVSLLARVTCNCFSISDGELQDVGVGLYPSMSLLNHDCQPNCIMMFEGKRLTLRAVRVIRSAEELTISYTDILAPSKDRRSQHWDELLKESQALLHRHSDVVPDRNIYMLRLLDLAMDACISLDDYETALEYGNRALGPYKLYFSDPHPSRAVELLRVGKLQHFLGRLEEARGSFTQAYSIMSVTHGAAHALTNQVQRRLSECQAELNTL
Protein: CCAAT/enhancer-binding protein gamma (C/EBP gamma) (Granulocyte colony-stimulating factor promoter element 1-binding protein) (GPE1-BP) (GPE1-binding protein) (Immunoglobulin enhancer-binding protein 1) (IG/EBP-1) (P53568)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity). Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:1709121, ECO:0000305|PubMed:2121606}.
Interaction partners:
- Cyclic AMP-dependent transcription factor ATF-4
- CCAAT/enhancer-binding protein beta
- MHC class II transactivator
- Cyclic AMP-dependent transcription factor ATF-5
- Asparagine synthetase
- DNA damage-inducible transcript 3 protein
- Hepatocyte nuclear factor 4-alpha
- Jun dimerization protein 2
- Protein c-Fos
- Cyclic AMP-responsive element-binding protein 1
Sequence:
MSKLSQPATTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAVPPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHSLADNVQPISTETTATNSDNPGQ