wanglab/gogpt-training-data huggingface dataset:
Protein: Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) (P80225)
Organism: Rattus norvegicus (Rat)
Function: This protein is responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15535}; Single-pass type II membrane protein. Secreted {ECO:0000250|UniProtKB:P08037}. Cell membrane {ECO:0000250|UniProtKB:P08037}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P08037}. Cell projection, filopodium {ECO:0000250|UniProtKB:P15535}. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid. {ECO:0000250|UniProtKB:P15535}.
Interaction partners:
Sequence:
PGATLQXAXXLLVAVXAXPPPPLGVXPKPXPG
Protein: Lipopolysaccharide biosynthesis protein WzxC (P77377)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
- Putative polysaccharide export protein Wza
- Colanic acid biosynthesis protein WcaK
- Tyrosine-protein kinase wzc
- Probable ECA polymerase
- O-antigen ligase
- Low molecular weight protein-tyrosine-phosphatase Wzb
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Putative colanic acid biosynthesis glycosyltransferase WcaL
- UTP--glucose-1-phosphate uridylyltransferase
Sequence:
MSLREKTISGAKWSAIATVIIIGLGLVQMTVLARIIDNHQFGLLTVSLVIIALADTLSDFGIANSIIQRKEISHLELTTLYWLNVGLGIVVCVAVFLLSDLIGDVLNNPDLAPLIKTLSLAFVVIPHGQQFRALMQKELEFNKIGMIETSAVLAGFTCTVVSAHFWPLAMTAILGYLVNSAVRTLLFGYFGRKIYRPGLHFSLASVAPNLRFGAWLTADSIINYLNTNLSTLVLARILGAGVAGGYNLAYNVAVVPPMKLNPIITRVLFPAFAKIQDDTEKLRVNFYKLLSVVGIINFPALLGLMVVSNNFVPLVFGEKWNSIIPVLQLLCVVGLLRSVGNPIGSLLMAKARVDISFKFNVFKTFLFIPAIVIGGQMAGAIGVTLGFLLVQIINTILSYFVMIKPVLGSSYRQYILSLWLPFYLSLPTLVVSYALGIVLKGQLALGMLLAVQIATGVLAFVVMIVLSRHPLVVEVKRQFCRSEKMKMLLRAG
Protein: Tricarboxylate carrier, putative (Q38FB0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004225}.
Interaction partners:
Sequence:
MLPCPSFSTTTPRFDMDTYLGRTFYFFSTINPLLCFETSNSLKRHQELLNRVAAGEEGVASDRQLWKARTAIEICVHPTTKEVIFPPYRMCAFLPVNSFIVPFMMSPTTIASPALTIFIQWFNQSYNCAVNYANRSSDKQPMSELSKAYVAAVGVSCAGALGATAMLKKVKGGTLKATAVRAGLPFVAVSAAAIVNLSLMRKNEWIPSGTGLQVVDEDGEVRGSSRVAGMQSLMMCSVTRVTWNLISMVLPLLMMRPLLARCAAVRARPVVYETALQIASLGVGVPLALGAFSTTVSVPANRLEPELRGLKRKDGSPVEIFTYYKGL
Protein: Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Large fibroblast proteoglycan) (PG-M) (Q75ZI3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, cilium, photoreceptor outer segment {ECO:0000256|ARBA:ARBA00004504}. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000256|ARBA:ARBA00004593}.
Interaction partners:
Sequence:
MMLLDVKHILWLICVCSAYSQDDSVRRMRVVRSSSRVHGALAQSVVLPCRFLVLPPLPGSSVITHSDHLRIKWTKLQSHGEAVAVVAQNGIVKMGQEYMGRVSVPSRPEDQGDASLTISRLRASDAGVYRCEVMHGIEDTQDSITLDVSGVVFHYRANTSRYSLNFTQAQQACADVDSSIATPEQLYSAYEDGFEQCDAGWMADQTVRYPIIRPRDGCHGDKWMKPGVKSYDVRNAYEKYDVYCYVGKLQGEVFFIDQKLSLDEARSACVGQDSVLASPGHLHAAWRDGMDQCDFGWLSDGSARYPVSVPRLQCGRGQLGVRTMYRNADRTGYPLPTMKLGAYCFRGRDPTTAPTAGPTTPTVPSDVLKISSLEVMSSAPTDDTIEEPPSMFSASMAPRDKPTPEAYPTIVTTQTGGILDTPSPTFGDYDDNSNLMVQGAPDLSLQGTVGSTTMVTPSYYDSIFSIKLPPQPTKGVKNPLDTPHGEYSSAEGSISGDTETPESVIPTSPVLVTTLQVDPDQPKVVYKEDGSTENITEGVVFAESSMGTPGLGEVIVHGSQSEVSKNVSFPIDISLLIVDIKDTNQSVESVLDFLGEPRGITDVLTSSENEPPLGSGDLEIYPSASVTVTPEVSFINGKHELTLQPVAEQEARGDQFDTVTPPIEEIIPDDEIVILMSEFEGVVSSPKTDESGLTTRSPVEPHFTTKISKPDLGSGDLEIYSSASVTITPEVSFINGKHELTLKPDVEHEARGDQFDTATPPMEEIIPDDEIVIVLAEAEGLTSSYKTDESGLTTRSPVEPYFTTKISESTTMSELPIFSTKSPSQEITPQAISFSTSINEESSGMRPTDDEEELTTLEGSADDLQSATASTDPDMVATDETEIGGTEKPTQAYGVHCSTQGPITTPETSQTTASSPVEKEIKPERDDFEGSTSAEEESSGQDMYSREEPKQPILSPTLSVPSHSFTTSSTSTHPKDPREPASLLLPSAEPAVNVVSTLQTRVIPEEKDQSRSTTKSPLLVPEFEKDVSTVFAISGDSGSGDHPTEALTKQPFIVTTLPSLFIQQTVETSVDANEPTKAFEGSAEDTTPLSFTTARTETKFTTQRSDARILPTNSLRAIMSSSQETVLIQKTHSEETTTLVVPSETTEETMLPSKFGFSTEEPLISTSVHSSGPITIADTNLSISESVQDITSTTSTTEDMIPTPKATSTSSFEETVVDYEDVQGASVVERQPPIREEFTTKKPEVWTDSSYTVESHVVDLQDHALCSVSVCENGGTCFSSRKGNVCVCMPGFSGERCENDVDECQSNPCRNGATCIDGINSFKCVCLPSYSGSLCEQDTEVCDFGWQKFQSHCYKYFTHRRTWEAAERECRLQGGHLTSVLSHEEQLFVNRLGHDYQWIGLNDKMFDNDFRWTDGHPMQFENWRDGQPDSFFSTGEDCVVMIWHESGQWNDVPCNYHLTFTCKKGTVSCGQPPLIKDAQVYGSMKPRYEINSLVRYHCKEGFIQRHVPTIRCREDGQWDKPKITCLNPSTFQKMYAHKYQNNNYYNSSKRRFSESQYRHRWSKTAEELKH
Protein: Cationic amino acid transporter 5 (O64759)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High-affinity permease involved in the transport of the cationic amino acids (e.g. arginine, and, to a lower extent, citrulline and glutamate). Transport mostly basic amino acids, and, to a lower extent neutral and acidic amino acids.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15377779}; Multi-pass membrane protein {ECO:0000269|PubMed:15377779}.
Interaction partners:
- Amino acid permease 1
- Probable polyamine transporter At3g13620
Sequence:
MEGEERGYWRWSKRDFFPEESFQSFGSYRAALSQTCSRFKNRLVSRSDDENERFELKKQSEHEMKRCLTWWDLVWFGFGSVIGAGIFVLTGQEAHEQAGPAIVLSYVVSGLSAMLSVFCYTEFAVEIPVAGGSFAYLRIELGDFAAFITAGNILLESIVGTAAVARAWTSYFATLLNRSPNALRIKTDLSSGFNLLDPIAVVVIAASATIASISTRKTSLLNWIASAINTLVIFFVIIAGFIHADTSNLTPFLPFGPEGVFRAAAVVYFAYGGFDSIATMAEETKNPSRDIPIGLLGSMSIITVIYCLMALSLSMMQKYTDIDPNAAYSVAFQSVGMKWGKYLVALGALKGMTTVLLVGALGQARYVTHIARTHMIPPIFALVHPKTGTPINANLLVAIPSALIAFFSGLDVLASLLSISTLFIFTMMPIALLVRRYYVRQDTPRVHLIKLITCLLFVVVSSMGTSAYWGMQRKGSWIGYTVTVPFWFLGTLGIVFFVPQQRTPKVWGVPLVPWLPCLSIATNIFLMGSLGAMAFVRFGVCTLAMLLYYFLLGLHATFDMAHQQIVPRT
Protein: Large ribosomal subunit protein mL55 (39S ribosomal protein L55, mitochondrial) (L55mt) (MRP-L55) (Q9CZ83)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P0C2B8}.
Interaction partners:
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein mL52
- 39S ribosomal protein L40
- Large ribosomal subunit protein mL65
- Large ribosomal subunit protein mL41
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein mL51
- Large ribosomal subunit protein mL62
- Large ribosomal subunit protein mL37
- Large ribosomal subunit protein bL12m
Sequence:
MPLAILLSLLRHCGVRAALPTPRHLHTSPWRADCSRASLTRLRRQAYARLYPVLLVKQDGSTIHIRYREPRRMLAMPLDLDALSPEERRARFRKREAQLQQKREEEPEVVDSFDTERYKQFWTKTKK
Protein: Molybdopterin synthase catalytic subunit 2 (EC 2.8.1.12) (MPT synthase subunit 2 2) (Molybdenum cofactor biosynthesis protein E 2) (Molybdopterin-converting factor large subunit 2) (Molybdopterin-converting factor subunit 2 2) (P9WJR1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).
Interaction partners:
- Molybdopterin synthase sulfur carrier subunit
- Probable molybdopterin biosynthesis Mog protein
- Cyclic pyranopterin monophosphate synthase 2
- GTP 3',8-cyclase 2
- Cyclic pyranopterin monophosphate synthase 1
- GTP 3',8-cyclase 1
- Cyclic pyranopterin monophosphate synthase 3
- Probable adenylyltransferase/sulfurtransferase MoeZ
- Sulfur carrier protein CysO
- Molybdopterin synthase sulfur carrier subunit
Sequence:
MTQVLRAALTDQPIFLAEHEELVSHRSAGAIVGFVGMIRDRDGGRGVLRLEYSAHPSAAQVLADLVAEVAEESSGVRAVAASHRIGVLQVGEAALVAAVAADHRRAAFGTCAHLVETIKARLPVWKHQFFEDGTDEWVGSV
Protein: Transcription factor STKL2 (Protein Storekeeper-like 2) (O23077)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription repressor that binds DNA in a sequence-specific manner, 5'-GCCT-3', to regulate the expression of PGR. Acts as a modulatory component for the glucose-triggered developmental leaf growth process.
Subcellular location: Nucleus {ECO:0000269|PubMed:27031427}.
Interaction partners:
Sequence:
MAPLESPATASSSEVESSSEEIFKSSSEESKPKDPVTVPSSKTLKSPSAAVNSKTDSSDDSEKQSFVLTRRKKKEGAAESPAVKSGKKRAGEGSTSRDMHVKRVKKEDDNKKANPQRVWSEEDEISLLQAVIDFKAETGTSPWDHKNAFFDIAKKSISFDVSHVQFFDKIRRLKNKYFVNRKNKSGESNHDKKCLGLAVLIWGSDGMNVESPVKKDESILVKGKANSKEKKVEKPLVIEDEQVILGADSEWFEESFLVPVIANLGLDEYSVKKKWSKVSLETKKKIQEKMKVVDAKKCELLLAEMDVLKDVTSVLAQTN
Protein: Secretoglobin family 2B member 2 (Secretoglobin-like protein) (Q4G0G5)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MRVTSATCALLLALICSVQLGDACLDIDKLLANVVFDVSQDLLKEELARYNPSPLTEESFLNVQQCFANVSVTERFAHSVVIKKILQSNDCIEAAF
Protein: C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) (Q16581)
Organism: Homo sapiens (Human)
Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Complement C3
- Complement C4-A
- C5a anaphylatoxin chemotactic receptor 1
- Complement C5
- High affinity immunoglobulin epsilon receptor subunit gamma
- Complement C1q subcomponent subunit A
- Interleukin-8
- fMet-Leu-Phe receptor
- Integrin beta-2
- V-set and immunoglobulin domain-containing protein 4
Sequence:
MASFSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQRTVNTIWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAISLDRCLVVFKPIWCQNHRNVGMACSICGCIWVVAFVMCIPVFVYREIFTTDNHNRCGYKFGLSSSLDYPDFYGDPLENRSLENIVQPPGEMNDRLDPSSFQTNDHPWTVPTVFQPQTFQRPSADSLPRGSARLTSQNLYSNVFKPADVVSPKIPSGFPIEDHETSPLDNSDAFLSTHLKLFPSASSNSFYESELPQGFQDYYNLGQFTDDDQVPTPLVAITITRLVVGFLLPSVIMIACYSFIVFRMQRGRFAKSQSKTFRVAVVVVAVFLVCWTPYHIFGVLSLLTDPETPLGKTLMSWDHVCIALASANSCFNPFLYALLGKDFRKKARQSIQGILEAAFSEELTRSTHCPSNNVISERNSTTV
Protein: S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase beta chain; S-adenosylmethionine decarboxylase alpha chain] (Q9HV35)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
Interaction partners:
- Polyamine aminopropyltransferase 1
- Polyamine aminopropyltransferase 2
- DUF155 domain-containing protein
- S-adenosylmethionine synthase
- S-adenosylmethionine decarboxylase proenzyme
- Acyl-homoserine-lactone synthase
- Acyl-homoserine-lactone synthase
- Response regulator protein PmrA
- Sensor protein kinase PmrB
- Thioester reductase
Sequence:
MAIQPLRLDPITVLGKQLVIELFDCVDQRFDDIQWIEESMLEAARQANATIITSAFHKFSPIGISGVVVIAESHLAIHTWPEYGYAAVDVFTCGDVLDGAQAVRVLSERLGSRRHLISSMDRGLGGHRLGLLSRSLAGNGPVDEDSPTLRWALGQGTGVA
Protein: Protein tyrosine phosphatase (EC 3.1.3.48) (Q8IIN1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta
Sequence:
MKSLENNEMHNLCPIHYYFNGRDYNSDTIINNVNIKYFNMDNCLGNANLHMDYLNPVLNHPTKIEHGKIKILILDAPTNDLLPLYIKEMKNYNVTDLVRTCERTYNDGEIQDAGINVHELIFPDGDAPTEDIVSNWLNIVNNVIKNNCAVAVHCVAGLGRAPVLASIVLIEFGMDPIDAIVFIRDRRKGAINKRQLQFLKEYRKKKKKKNCLRKCHFM
Protein: Vesicle-associated membrane protein 727 (AtVAMP727) (Q9M376)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q12255}. Endosome membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q12255}. Note=Co-localizes with VPS3. {ECO:0000269|PubMed:29463724}.
Interaction partners:
- Vesicle transport v-SNARE 11
- Syntaxin-51
- Syntaxin-22
- Syntaxin-121
- Vacuolar protein-sorting-associated protein 33 homolog
- Protein VACUOLELESS1
- Vacuolar sorting protein 18
- Syntaxin-61
- Tlg2p-like protein a
- Vesicle transport v-SNARE 12
Sequence:
MSQKGLIYSFVAKGTVVLAEHTPYSGNFSTIAVQCLQKLPTNSSKYTYSCDGHTFNFLVDNGFVFLVVADESTGRSVPFVFLERVKEDFKKRYEASIKNDERHPLADEDEDDDLFGDRFSVAYNLDREFGPILKEHMQYCMSHPEEMSKLSKLKAQITEVKGIMMDNIEKVLDRGEKIELLVDKTENLQFQADSFQRQGRQLRRKMWLQSLQMKLMVAGAVFSFILIVWVVACGGFKCSS
Protein: SKI family transcriptional corepressor 2 (Fussel-18 homolog) (LBX1 corepressor 1-like protein) (Ladybird homeobox corepressor 1-like protein) (Transcriptional corepressor Corl2) (A7M7C7)
Organism: Mus musculus (Mouse)
Function: Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:18522874}. Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MASSPLPGPNDILLASPSSAFQPDALSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQERLCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGENRPPKLPDNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCSYCNMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDKSPQDELVFAWEDVKAMFNGGSRKRALPQPSAHPACHPLSSVKAAAVAAAAAVAGGGGLLGPHLLGAPPPPPPPPPLAELAGAPHAHHKRPRFDDDDDSLQEAAVVAAASLSAAAASLSVAAATGGAGPGAGGPGGGCVAGVGVGASAGAGAAAGTKGPRSYPVIPVPSKGSFGGVLQKFPGCGGLFPHPYTFPAAAAAFGLCHKKEDAGTAAEALGGAGAGSAGAAPKAGLSGLFWPAGRKDAFYPPFCMFWPPRTPGGLPVPTYLQPPPQPPSALGCALGDSPALLRQAFLDLAEPGGAGGSAEAAPPPGQPPPVVANGPGSGPPATGGTGARDTLFESPPGGSGGDCSAGSTPPAEQGVTSGTGSASSGAGSVGTRVPAPHHPHLLEGRKAGGGSYHHSSAFRPVGGKDDAESLAKLHGASAGTPHSAPAHHHHHHHHPHHHHHHPPQPPSPLLLLQPQPDEPGSERHHPAPPPPPPPPPLAPQPHHRGLLSPEGTSCSYPSEDSSEDEEDEEEEQEVDVEGHKPLEGEEEEDGRDPEDEEEEDEETRVLLGDSLVGGGRFLQGRGLSEKGSGRDRTTPAVGAFPLALNSSRLLQEDGKLGDSGGSDLPAPPPPPLAPQKASSSGGSRPGSPVHHPSLEEEPSYKDNQKPKENNQVIISTKDDNFSDKNKGHGFFITDSDSSGDFWRERSGEHTQETNSPHSLKKDVENMGKEELQKVLFEQIDLRRRLEQEFQVLKGNTSFPVFNNFQDQMKRELAYREEMVQQLQIIPYAASLIRKEKLGAHLSKS
Protein: 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) (P46087)
Organism: Homo sapiens (Human)
Function: Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484, ECO:0000269|PubMed:8089149}. Nucleus {ECO:0000269|PubMed:36161484}. Note=Localizes predominantly in the nucleolus and to a smaller extent in the nucleus. {ECO:0000269|PubMed:36161484}.
Interaction partners:
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- Probable rRNA-processing protein EBP2
- 60S ribosome subunit biogenesis protein NIP7 homolog
- MKI67 FHA domain-interacting nucleolar phosphoprotein
- GTP-binding protein 4
- Nucleolar complex protein 2 homolog
- Ribosome biogenesis protein BOP1
- RNA-binding protein 28
- Ribosome production factor 2 homolog
- mRNA turnover protein 4 homolog
Sequence:
MGRKLDPTKEKRGPGRKARKQKGAETELVRFLPAVSDENSKRLSSRARKRAAKRRLGSVEAPKTNKSPEAKPLPGKLPKGISAGAVQTAGKKGPQSLFNAPRGKKRPAPGSDEEEEEEDSEEDGMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEALLPIERAARKQKAREAAAGIQWSEEETEDEEEEKEVTPESGPPKVEEADGGLQINVDEEPFVLPPAGEMEQDAQAPDLQRVHKRIQDIVGILRDFGAQREEGRSRSEYLNRLKKDLAIYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPVTLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPSLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSETATPTNVDLPQVIPKSENSSQPAKKAKGAAKTKQQLQKQQHPKKASFQKLNGISKGADSELSTVPSVTKTQASSSFQDSSQPAGKAEGIREPKVTGKLKQRSPKLQSSKKVAFLRQNAPPKGTDTQTPAVLSPSKTQATLKPKDHHQPLGRAKGVEKQQLPEQPFEKAAFQKQNDTPKGPQPPTVSPIRSSRPPPAKRKKSQSRGNSQLLLS
Protein: 3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) (3-hydroxyanthranilate oxygenase) (3-HAO) (3-hydroxyanthranilic acid dioxygenase) (HAD) (Q78JT3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Subcellular location: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03019}.
Interaction partners:
- Kynureninase
- 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
- Kynurenine 3-monooxygenase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Catalase
- Tryptophan 2,3-dioxygenase
- Kynurenine formamidase
- Indoleamine 2,3-dioxygenase 2
- Indoleamine 2,3-dioxygenase 1
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Sequence:
MERRVRVKSWVEENRASFQPPVCNKLMHQEQLKIMFVGGPNTRKDYHIEEGEEVFYQLEGDMILRVLEQGQHRDVPIRQGEIFLLPARVPHSPQRFANTMGLVIERRRLESELDGLRYYVGDTEDVLFEKWFHCKDLGTQLAPIIQEFFHSEQYRTGKPNPDQLLKELPFPLNTRSIMKPMSLKAWLDGHSRELQAGTSLSLFGDSYETQVIAHGQGSSKGPRQDVDVWLWQQEGSSKVTMGGQCIALAPDDSLLVPAGTSYVWERAQGSVALSVTQDPARKKPWW
Protein: LIM and senescent cell antigen-like-containing domain protein (A0A8I6A6W3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, focal adhesion {ECO:0000256|PIRNR:PIRNR038003}. Cell membrane {ECO:0000256|PIRNR:PIRNR038003}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR038003}.
Interaction partners:
Sequence:
MAFPGRARPSTIPENEEIPQTALNSVLEANGNEDERAVSNLQRRHSDIKVYKEFCDFYAKFNMANALASATCERCKGGFDPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVSCFACSTCNTKLTLKDKFVAIDLKPVCKYCYEKMPEELKRRLARREREARDKEKQRKRKPVCL
Protein: SCOCO-like protein 1 (Q3E784)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Uncharacterized protein YEL014C
- Ectonucleotide pyrophosphatase/phosphodiesterase 2
Sequence:
MSAENISTGSPTGKQPSSEVNLGEREAGTKNERMMRQTKLLKDTLDLLWNKTLEQQEVCEQLKQENDYLEDYIGNLMRSSNVLEK
Protein: Prenylated Rab acceptor protein 1 (PRA1 family protein 1) (Q9UI14)
Organism: Homo sapiens (Human)
Function: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O35394}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O35394}. Golgi apparatus {ECO:0000250|UniProtKB:O35394}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:O35394}. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. {ECO:0000250|UniProtKB:O35394}.
Interaction partners:
- Protein piccolo
- Plasminogen
- Vesicle-associated membrane protein 2
- PRA1 family protein 3
- Rap guanine nucleotide exchange factor 4
- Receptor expression-enhancing protein 5
- Protein YIF1A
- Ras-related protein Rab-1A
- Regulating synaptic membrane exocytosis protein 2
- Protein YIF1B
Sequence:
MAAQKDQQKDAEAEGLSGTTLLPKLIPSGAGREWLERRRATIRPWSTFVDQQRFSRPRNLGELCQRLVRNVEYYQSNYVFVFLGLILYCVVTSPMLLVALAVFFGACYILYLRTLESKLVLFGREVSPAHQYALAGGISFPFFWLAGAGSAVFWVLGATLVVIGSHAAFHQIEAVDGEELQMEPV
Protein: Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3) (Q3T0Q4)
Organism: Bos taurus (Bovine)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (By similarity). Exhibits histidine protein kinase activity.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P22392}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P22392}. Cell projection, ruffle {ECO:0000250|UniProtKB:P22392}. Nucleus {ECO:0000250|UniProtKB:P22392}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000250|UniProtKB:P22392}.
Interaction partners:
- Inosine triphosphate pyrophosphatase
- Nucleoside diphosphate kinase A 2
- Nucleoside diphosphate kinase
- Guanosine-3',5'-bis
- Cancer-related nucleoside-triphosphatase homolog
- Ribonucleoside-diphosphate reductase
- UMP-CMP kinase
- Cilia- and flagella-associated protein 206
- UMP-CMP kinase 2, mitochondrial
- GTP:AMP phosphotransferase AK3, mitochondrial
Sequence:
MAHAERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLQASEELLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEINLWFKPEELIEYKPCAFDWIYE
Protein: Annexin (B5XAE0)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MAGRGSVRASGNFNANQDAETLYKAMKGLGTDEDSIMKLLTSRSNSQRQQIKAAYKTLHGKDLVGDLQGELGGKFETLVVALMTPPILYDATTLRNAIKGAGTDEKVLIEILSSRTAQQVKDIIAAYRQEFDADLEEDVTGDTSGHFRRLLVILLQASRQQGVQEGNIETDAQTLFSAGEKNYGTDEDQFITILGNRSAEHLRRVFAAYMKLAGYEMEESVKRETSGGLRDLLLAVVKCARSVPAYFAETLYYSMSGAGTDDQALIRVMVSRSEVDMLDIRADYRRLFAKSLYSTIQGDTSGDYRKALLLHCGGDDA
Protein: Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) (O35986)
Organism: Rattus norvegicus (Rat)
Function: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ubiquitin-protein ligase E3A
Sequence:
MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSHSGSREHSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERDRKRSRSRPSSPAVRKKRRTRSRSPERHHRSSSGSTHSGSRSSSKKK
Protein: Glial fibrillary acidic protein (GFAP) (Q28115)
Organism: Bos taurus (Bovine)
Function: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P14136}. Note=Associated with intermediate filaments. {ECO:0000250|UniProtKB:P14136}.
Interaction partners:
- Aquaporin-4
- Macrosialin
- Microtubule-associated protein
- Oligodendrocyte transcription factor 2
- Synaptophysin
- Myelin basic protein
- Neurotrophic factor BDNF precursor form
- Albumin
- Doublecortin
- Protein S100-B
Sequence:
MERRRVTSATRRSYVSSSEMVVGGRRLGPGTRLSLARMPPPLPARVDFSLAGALNSGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLGTLRQKLQDETNQRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVASSNMHEAEEWYRSKFADLNDAAARNAELLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHAREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM