Protein: Serine-protein kinase ATM (EC 2.7.11.1) (D4ACL8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic vesicle {ECO:0000256|RuleBase:RU365027}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365027}.
Interaction partners:
- Nibrin
- CHK2 checkpoint homolog
- Serine/threonine-protein kinase ATR
- Breast cancer type 1 susceptibility protein homolog
- Cellular tumor antigen p53
- Double-strand break repair protein MRE11
- TP53-binding protein 1
- DNA repair protein RAD50
- Histone acetyltransferase KAT5
- X-ray repair cross-complementing protein 6
Sequence:
MSLALNDLLICCRQLEHDRATERRKEVDKFKRLIQDPETVQHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETESLRTAKSNVSASTQTSRQKKMQEISSLVRFFIKCANKRAPRLKCQDLLNYVMDTVKDSSNGATYGADCSNILLKDILSVRKYWCEVSQQQWLELFSLYIRLYLKPSQDINRVLVARIIHAVTRGCCSQTDGLPSKFLDLFSKAIQYARQEKSSPGLSHILAALNIFLKTLAVNFRKRVCEIGDEILPTLLYIWTQHRLNDSLKEVIIELIHLQIYIHHPQGAKAPEEGAYESMKWKRILYNLYDLLVNEISHIGSRGKYSSGSRNIAVKENLIDLMADVCYQLFNADTRSVEISQSYATQRESTDYSVPCKRRKIDIGWEVIKDYLQKSQNDFDLVPWLQITTRLISKYPSSLPNCELSPLILILYQLLPQQRRGERIPHVLRCLTEVALCQGKKSNLESSQKSDLLKLWIKIWSITFRGISSEQTQTENFGLLGAIIQGSLVELDREFWKLFTGSACKPSSPSVRCLTLALSMCVVPDAIKMGTEQSVCDANRSFSVKESIMRWLLFYQLEGDLEDSAEPPPILQSNFPHLILEKILVSLTMKNSKAAMKFFQSAPECEQHCEDTEEPSFSEAEELFLQTTFDKMDFLTPVKEDTVEKFQSRVGFSVHQNLKESLDHYLLGLSEQLLSNYSSEITSSETLVRCSSLLVGVLGCYCYMGVITEDEAYKSELFQKAKSLMQCAGESISLFKNKTNEESRVGSLRSVIHLCTSCLCRHTKHTLNKIASGFFLRLLTSKLMNDIADICKSLASCTKKPFDYGEEHSLRDDDDDGDGGDGGESLMETQGSSSTDLFSDYSASTVSDANDYGENQNAVGAANPLTADWLSRQDHLLLDMLRFLCLSVTACQSRTASFRGADIRRKLLMLLDPSTLDLTKSLHLHMYLVLLKDLPGKEHLLPMEDVVELLQPLSLVCSLYRRDQDVCKTILSNVLHIVTNLGQGSVDTESTRNAQGQFLTVMGAFWHLTKEKKCIFSVRMALVKCLQTLLEADPYSKWAILNVKGQDFPVREAFPQFLADGHHHVRMLAAGSISRLFQDMRQGDSSRSLKALPLKFQQTSFNSAYMIAEAGIRELLCDSQNPDLLDEIYNRKSVLLTVIAVVLHCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSESFGCRCLEDFMASHLDYLVLEWLNLQDAKYSLSSFPFTLLNYMSVEDFYRSCYKILIPHLVIRKHFDEVKSIANQIQRCWKSLLIDCFPKMLVHILPYFACEGTGDSSSAQKRETATEVYDTLKGEDFLGKQIDQVFISNLPEIVVELLMTLHETADSDSGQSPDLCDFSGDLDPAPNPPYFPSHVIKATFAYISSCHKTKFKSILEILSKIPDSYQKILLAICEQAAETNNVFKKHRILKIYHLFVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYINKRSSHFTDVSLRSFSLCCDLLSRVCRTAVTHCKDALENHLHVIVGTLIPLVDYQEVQEQVLDLLKYLVIDNKDNKNLFVTIKLLDPFPDHVVFKDLRLTQQKIKYSGGPFTLLEEINHFLSVSAYNPLPLTRLEGLKDLRRQLEQHKDQMLDLVRASQDNPQDGIVVKLVVSLLQLSKMAVNQTGEREVLEAVGRCLGEIGPLDFSTIAVQHSKDTPYTKAYGLPEDRELQWTLIMLTALNNTLVEDSVKIRSAAATCLKNILATKTGHIFWENHKTSADPMLTYLQPFRASRKKFLELPQFVKEDALEGLDDVNLWVPQSESHDIWIKTLTCAFLDSGGIKSEILQLLKPMCEVKTDFCQMVLPYLIHDVLLQDTHESWRTLLSTHVRGFFTNCFKHSSQASRSATPANSDSESENFLRCCLDKKSQRTMLAVVDYLRRQKRPSSGTAFEDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYSDKKNMDEQEKRSPTFEEGSQGTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKVLQPLTRIRTYEHEATWEKALVTYDLETTISSSTRQSGIIQALQNLGLSHILSIYLKGLDHERREWCGELQELHYQAAWRNMQWDLCTSANQELEGTSYHESLYNALQCLRNREFSTFYDSLRHARVKEVEELSKGSLESVYSLYPTLSRLQAVGELENSGELFSRSVTDRERSEVYLKWQKHSQLLKDSDFSFQEPLMALRTVILEILVQKEMENSQGGCSKDILTKHLVEFSVLARTFKNTQLPERAIFKIKQYNPAICGISEWHLEEAQVFWAKKEQSLALSILKQMIKKLDSSFREVCNEAGLKGLHAECLRVCGNWLAETCLENPAVIMQTYLEKAVKVAGSYDGDSRELRNGQMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLIREHKIQTNRYTIKVQRELELDECALRALKEDRKRFLCKAVENYISCLLSGEEHDLWVFRLCSLWLENSGVSEVNGMMKRDGMKISSYKFLPLMYQLAARMGTKMTGGLGFHEVLNNLISRISMDHPHHTLFIILALANANKDEFLSKPETARRGRITKNAPKESSQLDEDRAEAASRIIHTIRSARRTMVKDMEALCDAYIILANLDASQWRNQRKGISIPANQPITKLKNLEDVVVPTMEIKVDPTGEYEKLVTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNMLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIGEYLVNNEEGAHKRYRPNDLSANQCQKKMMEVQKKSFEEKYETFMTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRCCEKTMEVMRSSQEALLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETDLQSTPSADDQECKRSLSDTDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAMDPKNLSRLFPGWKAWV