wanglab/gogpt-training-data huggingface dataset:
Protein: PHD finger protein 14 (Q9D4H9)
Organism: Mus musculus (Mouse)
Function: Histone-binding protein (By similarity). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation. Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells.
Subcellular location: [Isoform 1]: Nucleus {ECO:0000269|PubMed:22730381}. Chromosome {ECO:0000250|UniProtKB:O94880}. Note=Mainly localized in the nucleus of interphase cells. In mitotic cells, colocalizes with condensed chromatin during metaphase and anaphase. {ECO:0000250|UniProtKB:O94880}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:O94880}.
Interaction partners:
- High mobility group protein 20A
Sequence:
MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDIQVKEEQLKNSTEEIMPSDKQLIKMEKKEEEENGERPRKKKEKEKEKEKEREKDKEKATVSDSAAASAAGTTPATSPPAVTSPSVPTTTTTTTEEQVSEPKKWNLRRNRPLLDFVSMEELNAMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDDDEGSGSEEDENDEGNDEDHSSPASEAGGKKKRSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNLNGKLRSEGQGIWALLGRITGQKLNVPAILRAPKERKPSKKEGGTQKTSALPTVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDVPPEPKKIPIRNTRTRGRKRSFVPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECSTCKGTGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSSSSKEDENEAEKKNASQELSMEQKTPKK
Protein: Male-specific lethal 1 homolog (MSL-1) (Hampin) (Male-specific lethal 1-like 1) (MSL1-like 1) (Q6PDM1)
Organism: Mus musculus (Mouse)
Function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub) (By similarity). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. Isoform 2, isoform 3, isoform 4 and isoform 5 can medite histone H4 acetylation at 'Lys-16' (H4K16ac).
Subcellular location: Nucleus {ECO:0000269|PubMed:17335777, ECO:0000269|PubMed:24913909}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:24913909}. Nucleus speckle {ECO:0000269|PubMed:24913909}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:19390865, ECO:0000269|PubMed:24913909}. Nucleus speckle {ECO:0000269|PubMed:24913909}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:16119455}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24913909}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleoplasm {ECO:0000269|PubMed:24913909}.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus, nucleoplasm {ECO:0000269|PubMed:24913909}.
Interaction partners:
- MSL complex subunit 3
- E3 ubiquitin-protein ligase MSL2
- MSL complex subunit 3B
- Histone acetyltransferase KAT8
- Histone acetyltransferase KAT5
- KAT8 regulatory NSL complex subunit 2
- KAT8 regulatory NSL complex subunit 3
- KAT8 regulatory NSL complex subunit 1
- E1A-binding protein p400
- PHD finger protein 20
Sequence:
MTMRSAVFKAAAAPAGGNPEQRLDYERAAALGGPEDESGAAEAHFLPRHRKLKEPGPPLASSQGGSPSPSPAGCGGGKGRGLLLPAGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPVAAGAGCSPRPKYQAVLPIQTGSIVVAAAKEPTPWAGDKGGAAPPAATASDPAGPPPLPLPGPPPLAPTATAGTLAASEGRWKSIRKSPLGGGGGSGASSQAACLKQILLLQLDLIEQQQQQLQAKEKEIEELKSERDTLLARIERMERRMQLVKRDNEKERHKLLQGYEPEEREEAELSEKIKLERQPELCETSQALPSKPFSCGRSGKGHKRKTPFGNTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSISETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEMEDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDILENLDDSVFSKRHAKLELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLLITPFLPVVAFGRPLPKLAPQNFELPWLDERSRCRLEIQKKHTPHRTCRK
Protein: GH02671p (Liquid facets-Related, isoform C) (Q9VD13)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVDKFISMWKVRELADKVTNVVMNYTETEGKVREATNDDPWGPTGPLMQELAYSTFSYETFPEVMSMLWKRMLQDNKTNWRRTYKSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYTFTDEGGKDQGINVRHKVRELIDFIQDDDRLREERKKAKKNKDKYIGMSSDAMGMRSGGYSGYSGGSGGGGGGSGGYNDGDYRSSRGDNWYSDKSADKDRYEDDDTHYDGEREGSDSDSPSPRRNYRYNDRASPAEVASEAKPSSLNMNIRSKTVSSPVSKQPTSTASAKPALSQKKIDLGAAANFGKPAPGGAAGIHSPTHRDTPTSVDLMGGASPSPSTSKANNNTQSNNNDLLDDLFKTCSPPPGQEKTLNSAAVIVDDDDDFNPRASDASQQEFGDFASAFGQPSAGSTISEPPSTGLVPAANDEFADFAAFQGSTTSTSALDGNLLKTATPANDSFDLFNSAPTSTAAATTATDLLAGLGDLSIHQSMPMDNMMPPIPAVTGNNLLQPMSVTNNNNNTNGGAVPAAASVQSTAVGATWSGDLKGGKMNIDLDNLLMSKSGKPSAPAPSMNALKTNSPAKAPLNVQTGGGFPGLSPMTSPNIFGAPAPQQSIPQNQSAFANFGAFQQQQQNHSNNNNNSSSAFDLFQ
Protein: Mas-related G-protein coupled receptor member D (Beta-alanine receptor) (G-protein coupled receptor TGR7) (Q8TDS7)
Organism: Homo sapiens (Human)
Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15037633}; Multi-pass membrane protein {ECO:0000269|PubMed:15037633}. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
Interaction partners:
- Guanine nucleotide-binding protein G
- Pro-FMRFamide-related neuropeptide FF
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Transient receptor potential cation channel subfamily V member 1
- Transient receptor potential cation channel subfamily A member 1
Sequence:
MNQTLNSSGTVESALNYSRGSTVHTAYLVLSSLAMFTCLCGMAGNSMVIWLLGFRMHRNPFCIYILNLAAADLLFLFSMASTLSLETQPLVNTTDKVHELMKRLMYFAYTVGLSLLTAISTQRCLSVLFPIWFKCHRPRHLSAWVCGLLWTLCLLMNGLTSSFCSKFLKFNEDRCFRVDMVQAALIMGVLTPVMTLSSLTLFVWVRRSSQQWRRQPTRLFVVVLASVLVFLICSLPLSIYWFVLYWLSLPPEMQVLCFSLSRLSSSVSSSANPVIYFLVGSRRSHRLPTRSLGTVLQQALREEPELEGGETPTVGTNEMGA
Protein: Integrator complex assembly factor WDR73 (WD repeat-containing protein 73) (Q6P4I2)
Organism: Homo sapiens (Human)
Function: May play a role in the regulation of microtubule organization and dynamics.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25466283, ECO:0000269|PubMed:39032489}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25466283}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:25466283}. Cleavage furrow {ECO:0000269|PubMed:25466283}. Note=During interphase, located in the cytoplasm (PubMed:25466283). During mitosis, accumulates at the spindle poles and microtubule asters and later in the cleavage furrow (PubMed:25466283). {ECO:0000269|PubMed:25466283}.
Interaction partners:
- Histone acetyltransferase type B catalytic subunit
- Polycomb protein SUZ12
- Chromatin assembly factor 1 subunit B
- Polycomb protein EED
- EKC/KEOPS complex subunit TP53RK
Sequence:
MDPGDDWLVESLRLYQDFYAFDLSGATRVLEWIDDKGVFVAGYESLKKNEILHLKLPLRLSVKENKGLFPERDFKVRHGGFSDRSIFDLKHVPHTRLLVTSGLPGCYLQVWQVAEDSDVIKAVSTIAVHEKEESLWPRVAVFSTLAPGVLHGARLRSLQVVDLESRKTTYTSDVSDSEELSSLQVLDADTFAFCCASGRLGLVDTRQKWAPLENRSPGPGSGGERWCAEVGSWGQGPGPSIASLGSDGRLCLLDPRDLCHPVSSVQCPVSVPSPDPELLRVTWAPGLKNCLAISGFDGTVQVYDATSWDGTRSQDGTRSQVEPLFTHRGHIFLDGNGMDPAPLVTTHTWHPCRPRTLLSATNDASLHVWDWVDLCAPR
Protein: Golgi pH regulator B (Protein GPR89B) (P0CG08)
Organism: Homo sapiens (Human)
Function: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18794847}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEIRQYVVQVIFSVTFAFSCTMFELIIFEILGVLNSSSRYFHWKMNLCVILLILVFMVPFYIGYFIVSNIRLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAMARRTMFQKGEVHNKPSGFWGMIKSVTTSASGSENLTLIQQEVDALEELSRQLFLETADLYATKERIEYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGKTDPVTRGIEITVNYLGIQFDVKFWSQHISFILVGIIIVTSIRGLLITLTKFFYAISSSKSSNVIVLLLAQIMGMYFVSSVLLIRMSMPLEYRTIITEVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHKQAPEKQMAP
Protein: RUNX family transcription factor 1 (A8MZI9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPAAPRGPAQGEAAARTRSRDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
Protein: Uncharacterized J domain-containing protein C4H3.01 (Q10209)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MATPVDTEYYDLLGISTDATAVDIKKAYRKLAVKYHPDKNPDDPQGASEKFQKISEAYQVLGDEKLRSQYDQFGKEKAVPEQGFTDAYDFFTNLFGGAPFREWVGELSFVKEMFREEDSAVEQGQMNDKQQLLLESSEPTPTIKQQFNDRKKNAQIREREALAKREQEMIEDRRQRIKEVTENLEKRLDDWIAKATTEEGLNALREKYTQEANTLRIESFGVEILHAIGEVYTQKGRTVLKSSKFGIGGFWSRMKEKGKIARATWDTVSAAMDAKLSIDQMQKLEDKGEDQASAEERAKLELDITGKILRASWCGARYDIQGVLREACSNLLKKRVPTELRLKRAHALLEIGTIFSNVEADPDDPNRIFENLILENKKKRKKGSEAKPPKAT
Protein: WUSCHEL related homeobox 11 (B3H5D3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MDQEQTPHSPTRHSRSPPSSASGSTSAEPVRSRWSPKPEQILILESIFHSGMVNPPKEETVRIRKMLEKFGAVGDANVFYWFQNRRSRSRRRQRQLQAAAAAADATTNTCDQTMMVSNSLPHHSGSDLGFGGCSTSSNYLFGGSSQVPSFFLGLSSSPSSCSSSSSTSSSASSSSSYGGGCDNQSNSGMENLLTMSGQMSYHEATHHHYQNHSSNVTSILCPSDQNSNFQYQQGAITVFINGVPTEVTRGGIDMKATFGEDLVLVHSSGVPLPTDEFGFLMHSLQHGEAYFLVPRQT
Protein: Nectin cell adhesion molecule 3 (D4A5C0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}. Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Nectin-1
- T-cell immunoreceptor with Ig and ITIM domains
- Afadin
- PVR cell adhesion molecule.
- Nectin cell adhesion molecule 2
- Cell adhesion molecule 1
- Partitioning defective 3 homolog
- Cell adhesion molecule 3
- Nectin-4
- Junctional adhesion molecule C
Sequence:
MARTPGPALLCPGGGKAQLSSASPPAAGLLLPAPTPPPLLLLLIPLLLFSRLCGALAGSIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSTQTVAVHHPQYGFSVQGEYQGRILFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLMKGPDSLIDGGNETVAAVCIAATGKPVARIDWEGDLGEMESTITSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGEWPDGLLASDNTLHFVHPLTFNYSGVYVCKVTNSLGQRSDQKVIYISDPPTTTTLQPTVQWRSSTADVQDLATEHKKLPFPLSTLATLKDDTIGTIIASVVGGALFVVLVSILAGVFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQHDEHDSYPDSVKKENKAPVNNLIRKDYLEEPEKTQWNNVENLTRFERPMDYYEDLKMGMKFVSDERHPA
Protein: Glutamate receptor ionotropic, kainate 5 (GluK5) (Glutamate receptor KA-2) (KA2) (Glutamate receptor gamma-2) (GluR gamma-2) (Q61626)
Organism: Mus musculus (Mouse)
Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate = glutamate >> AMPA.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12954862}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000269|PubMed:12954862}; Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000269|PubMed:12954862}; Multi-pass membrane protein {ECO:0000255}. Note=Association with GRIK2 is required for its cell membrane localization and channel activity. {ECO:0000250|UniProtKB:Q16478}.
Interaction partners:
- Glutamate receptor ionotropic, kainate 2
- Glutamate receptor ionotropic, kainate 1
- Glutamate receptor ionotropic, kainate 3
- Glutamate receptor ionotropic, kainate 4
- Disks large homolog 4
- Glutamate receptor ionotropic, NMDA 2D
- Voltage-dependent calcium channel gamma-2 subunit
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2C
Sequence:
MPAELLLLLIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDDPGPPGGPRPQAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGTPAEATSPPRPRPGPTGPRELTEHE
Protein: Transcription factor TCP5 (Q9FME3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164). Participates in ovule develpment.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor TCP15
- Transcription factor TCP14
- Transcription factor TCP7
- Transcription factor TCP21
- Transcription factor TCP20
- Transcription factor TCP8
- Transcription factor TCP22
- Transcription factor TCP19
- Transcription factor TCP16
- Zinc finger protein JAGGED
Sequence:
MRSGECDEEEIQAKQERDQNQNHQVNLNHMLQQQQPSSVSSSRQWTSAFRNPRIVRVSRTFGGKDRHSKVCTVRGLRDRRIRLSVPTAIQLYDLQDRLGLSQPSKVIDWLLEAAKDDVDKLPPLQFPHGFNQMYPNLIFGNSGFGESPSSTTSTTFPGTNLGFLENWDLGGSSRTRARLTDTTTTQRESFDLDKGKWIKNDENSNQDHQGFNTNHQQQFPLTNPYNNTSAYYNLGHLQQSLDQSGNNVTVAISNVAANNNNNLNLHPPSSSAGDGSQLFFGPTPPAMSSLFPTYPSFLGASHHHHVVDGAGHLQLFSSNSNTASQQHMMPGNTSLIRPFHHLMSSNHDTDHHSSDNESDS
Protein: U3 small nucleolar RNA-associated protein 14 homolog B (Juvenile spermatogonial depletion protein) (Q6EJB6)
Organism: Mus musculus (Mouse)
Function: Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 18 homolog
- Something about silencing protein 10
- Nucleolar protein 14
- U3 small nucleolar ribonucleoprotein protein MPP10
- WD repeat-containing protein 46
- Nucleolar protein 10
- WD repeat domain 36
- U3 small nucleolar RNA-associated protein 4 homolog
- WD repeat-containing protein 3
- U3 small nucleolar RNA-associated protein 6 homolog
Sequence:
MNMARNVTDLLALSQQEELVDLPENYPLSTSEDEGDSDGEGKRQKLLEAVSSLGRKNKWKLAERSEASRMVSEFNVTSEGSGEKLVLSDLLGSATALSSVAAVKKQLHRVKSKTLTPPLNKEEADRALREAAFSKTSQMLSRWDPVVLKNRQAEQLIFPMEKEPPAVAPIEHVFTDWKVRTPLEQEVFNLLHKNKQPVTDPLLTPVETASIRAMSLEEAKIRRAELQRMRALQSYYEARARREKRIKSKKYHRALKKGKAKKALKEFEELWKDCPNAALQELEKMEKARMTERMSLKHQGSGKWAKSKAIMAKYDPEARKAMQEQLAKNRELTQKLQVVSESEEEDGCTEEGIVSVSHGMDDLQMNADGVNPWMLSSCNSNAKRGEIKTDPEQMPEFVAHVSSESEGDERPVAEELVLKERSFQERVDPNNAKLMDGQETEDSDSQEVLQKLNKESHQSDNQKVSSEENVLHIQREDLASEKLLVLQRLERAHVLEQQGELSKEEHYPKKGLSRPLLKGDWKEMKPLTNPDASGGKKKKEQMIDLRNLLTANSSPVRSLAVPTIQQLEDEVETDHKQLIREAFAGDDVIREFLKEKREAIETNKPKDLDLSLPGWGEWVGMGLKPSAKKRRRFLIKAPESSPRKDKNLPNVIISEKRNIHAAAHQVRALPHPFTHQQQFERTIQNPIGYMWNTQRTFQKLTVPKVGTKLGHIIKPIKAENVGYCSSTRSDLSILQSSQKCLSRKQQKQLKKLSSAD
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 (Oligosaccharyl transferase subunit TUSC3) (Magnesium uptake/transporter TUSC3) (Protein N33) (Tumor suppressor candidate 3) (Q8BTV1)
Organism: Mus musculus (Mouse)
Function: Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
- Mannosyl-oligosaccharide glucosidase
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2
Sequence:
MSARAAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFVKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFGMVDYDEGTDVFQQLNMNSAPTFMHFPSKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK
Protein: SH3 domain-containing protein 2 (AtSH3P2) (Q8VWF1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulator for autophaosome formation and/or maturation. Binds phosphatidylinositol-phosphate; highest affinity for vesicles containing PtdIns(3,4,5)P(3), followed by those containing PtdIns(4,5)P(2) and PtdIns(3,4)P(2), with minimal binding to phosphatidylinositol monophosphates, including PtdIns(3)P. Together with DRP1A, converts the fused vesicles to tubular structures at the cell plate during cytokinesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24249832, ECO:0000269|PubMed:25699591}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:11701884, ECO:0000269|PubMed:25699591}. Cell membrane {ECO:0000269|PubMed:25699591, ECO:0000269|PubMed:28584166}. Late endosome {ECO:0000269|PubMed:25699591, ECO:0000269|PubMed:28584166}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:24249832, ECO:0000269|Ref.9}; Peripheral membrane protein {ECO:0000269|Ref.9}. Note=Transolcate from the cytosol to the phagophore assembly site/preautophagosome structure upon autophagy induction (PubMed:24249832). Localized at the leading edge of the cell plate in dividing cells, especially in constricted or curved regions (PubMed:28584166). Observed at the plasma membrane and in endosomal compartments in non-dividing cells (PubMed:28584166). {ECO:0000269|PubMed:24249832, ECO:0000269|PubMed:28584166}.
Interaction partners:
- Protein FREE1
- AMSH-like ubiquitin thioesterase 3
- Phragmoplastin DRP1A
- Autophagy-related protein 8f
- Vacuolar-sorting protein BRO1
- Vacuolar protein sorting-associated protein 2 homolog 1
- AMSH-like ubiquitin thioesterase 1
- ESCRT-related protein CHMP1B
- Protein NBR1 homolog
- ATG8-interacting protein 1
Sequence:
MDAIRKQASRLREQVARQQQAVFKQFGGGGYGSGLADEAELNQHQKLEKLYISTRAAKHYQRDIVRGVEGYIVTGSKQVEIGTKLSEDSRKYGSENTCTNGNVLTRAALNYGRARAQMEKERGNMLKALGTQVAEPLRAMVLGAPLEDARHLAQRYDRMRQEAEAQATEVARRQAKARESQGNPDILMKLESAEAKLHDLKSNMTILGKEAASALASVEDQQQKLTLERLLSMVESERAYHQRVLQILDQLEGEMVSERQRIEAPSTPSSADSMPPPPSYEEANGVFASQMHDTSTDSMGYFLGEVLFPYHGVTDVELSLSTGEYVVVRKVTGSGWAEGECKGKAGWFPYGYIERRERVLASKVSEVF
Protein: Heme-responsive zinc finger transcription factor HAP1 (CYP1 activatory protein) (Heme activator protein 1) (P0CE41)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulation of oxygen dependent gene expression. It modulates the expression of Iso-1 (CYP1) and Iso-2 (CYP3) cytochrome c. In response to heme, promotes transcription of genes encoding functions required for respiration, controlling oxidative damage and repression of anaerobic genes. Binds to the sequence 5'-CGGNNNTNNCGG-3' (By similarity). Is non-functional in terms of iso-1 cytochrome c expression in strain S288c and its derivatives.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
Interaction partners:
- ATP-dependent molecular chaperone HSP82
- Oxygen-dependent coproporphyrinogen-III oxidase
Sequence:
MSNTPYNSSVPSIASMTQSSVSRSPNMHTATTPGANTSSNSPPLHMSSDSSKIKRKRNRIPLSCTICRKRKVKCDKLRPHCQQCTKTGVAHLCHYMEQTWAEEAEKELLKDNELKKLRERVKSLEKTLSKVHSSPSSNSLKSYNTPESSNLFMGSDEHTTLVNANTGSASSASHMHQQQQQQQQQEQQQDFSRSANANANSSSLSISNKYDNDELDLTKDFDLLHIKSNGTIHLGATHWLSIMKGDPYLKLLWGHIFAMREKLNEWYYQKNSYSKLKSSKCPINHAQAPPSAAAAATRKCPVDHSAFSSGMVAPKEETPLPRKCPVDHTMFSSGMIPPREDTSSQKRCPVDHTMYSAGMMPPKDETPSPFSTKAMIDHNKHTMNPPQSKCPVDHRNYMKDYPSDMANSSSNPASRCPIDHSSMKNTAALPASTHNTIPHHQPQSGSHARSHPAQSRKHDSYMTESEVLATLCEMLPPKRVIALFIEKFFKHLYPAIPILDEQNFKNHVNQMLSLSSMNPTVNNFGMSMPSSSTLENQPITQINLPKLSDSCNLGILIIILRLTWLSIPSNSCEVDLGEESGSFLVPNESSNMSASALTSMAKEESLLLKHETPVEALELCQKYLIKFDELSSISNNNVNLTTVQFAIFYNFYMKSASNDLTTLTNTNNTGMANPGHDSESHQILLSNITQMAFSCGLHRDPDNFPQLNATIPATSQDVSNNGSKKANPSTNPTLNNNMSAATTNSSSRSGSADSRSGSNPVNKKENQVSIERFKHTWRKIWYYIVSMDVNQSLSLGSPRLLRNLRDFSDTKLPSASRIDYVRDIKELIIVKNFTLFFQIDLCIIAVLNHILNVSLARSVRKFELDSLINLLKNLTYGTENVNDVVSSLINKGLLPTSEGGSVDSNNDEIYGLPKLPDILNHGQHNQNLYADGRNTSSSDIDKKLDLPHESTTRALFFSKHMTIRMLLYLLNYILFTHYEPMGSEDPGTNILAKEYAQEALNFAMDGYRNCMIFFNNIRNTNSLFDYMNVILSYPCLDIGHRSLQFIVCLILRAKCGPLTGMRESSIITNGTSSGFNSSVEDEDVKVKQESSDELKKDDFMKDVNLDSGDSLAEILMSRMLLFQKLTKQLSKKYNYAIRMNKSTGFFVSLLDTPSKKSDSKSGGSSFMLGNWKHPKVSNMSGFLAGDKDQLQKCPVYQDALGFVSPTGANEGSAPMQGMSLQGSTARMGGTQLPPIRSYKPITYTSSNLRRMNETGEAEAKRRRFNDGYIDNNSNNDIPRGISPKPSNGLSSVQPLLSSFSMNQLNGGTIPTVPSLTNITSQMGALPSLDRITTNQINLPDPSRDEAFDNSIKQMTPMTSAFMNANTTIPSSTLNGNMNMNGAGTANTDTSANGSALSTLTSPQGSDLASNSATQYKPDLEDFLMQNSNFNGLMINPSSLVEVVGGYNDPNNLGRNDAVDFLPVDNVEIDGVGIKINYHLLTSIYVTSILSYTVLEDDANDEK
Protein: Hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) (Q9M6U3)
Organism: Brassica juncea (Indian mustard) (Sinapis juncea)
Interaction partners:
Sequence:
MAKNVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKLEGKEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLRNASSIDEAAKEKFTPYSSLSLDESYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKQVGNMYTASLYAAFASLVHNKHSDLAGKRVVMFSYGSGSTATMFSLRLCENQSPFSLSNIASVMDVGGKLKARHEYAPEKFVETMKLMEHRYGAKEFVTSKEGILDLLAPGTYYLKEVDSLYRRFYGKKGDDGSITNGH