wanglab/gogpt-training-data huggingface dataset:
Protein: Putative colanic acid polymerase (P71238)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
- Putative colanic acid biosynthesis glycosyl transferase WcaE
- Putative colanic acid biosynthesis glycosyl transferase WcaA
- Putative colanic acid biosynthesis acetyltransferase WcaF
- Putative polysaccharide export protein Wza
- Putative colanic acid biosynthesis glycosyl transferase WcaC
- Putative colanic acid biosynthesis acetyltransferase WcaB
- Tyrosine-protein kinase wzc
- GDP-mannose 4,6-dehydratase
- GDP-L-fucose synthase
- GDP-mannose mannosyl hydrolase
Sequence:
MSTSIRICSYLLLPLIYLLVNVKIAQLGESFPITIVTFLPVLLLLFLERISVKKLMIALGIGAGLTAFNYLFGQSLDASKYVTSTMLFVYIVIIIGMVWSIRFKTISPHNHRKILRFFYLVVGLVVALAAVEMAQIILTGGSSIMESISKYLIYSNSYVLNFIKFGGKRTTALYFEPAFFALALISIWLSIKQFGIKTPKTDAMILAGIILSGSFSGVMTFILFYLLEWAFQYLNKEAIKKKLPLALISLAVFLVGVVIAFPYISTRLGDLGTEGSSSYYRIVGPLVMVGYSLTHIDGVVRFGSLYEYVASFGIFNGADVGKTIDNGLYLLIIYFSWFAVFLSLWYMGKVIKMMINAFGDNRNFRVQLYLFTPVSLFFTGSIFSPEYAFLIVCPFILRKALNITR
Protein: 14-3-3-like protein (P54632)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Probable serine/threonine-protein kinase roco5
- Heat shock factor-type DNA-binding domain-containing protein
- Probable serine/threonine-protein kinase roco11
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase qkgA
- Probable serine/threonine-protein kinase roco6
- M-phase inducer phosphatase
- Metabotropic glutamate receptor-like protein R
- RapGAP/RanGAP domain-containing protein
- Cystatin-A1
Sequence:
MTREENVYMAKLAEQAERYEEMVEAMKKVAELDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESKGNENHVKKIKEYKCKVEKELTDICNDILEVLESHLIVSSASGESKVFYYKMKGDYFRYLAEFATGNPRKTSAESSLIAYKAASDIAVTELPPTHPIRLGLALNFSVFYYEILNSPDRACNLAKTAFDDAIAELDTLSEDSYKDSTLIMQLLRDNLTLWTSDVHNMEKNQDGDDDQNEPGM
Protein: Solute carrier family 17 member 3 (E9PTR8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Sodium-dependent phosphate transport protein 1
- Solute carrier family 22 member 12
- Solute carrier family 22 member 6
- Solute carrier family 2 member 9
Sequence:
MATVVELSPTSEQCEFVLGLPVNKKTPPRKVPSLCSMRYSIAFIAHICNFTLIAQNSIISITMVAMVNNTDQPSHLNSSTEWFPDGLNGDQHEASKHLSIKAPVYNWSPQTQGIIFSSVQYGMMLMQGPGGYLAGKLGTKKVVGIALLGSSLLTLCIPLAANLGLAFLLATRAVQGLTQGAGYGGQFALWQKWAPPNERSRLCSIAMSGMILGIFAVLLVGGIISEALGWPFVFYIFGSIGVVCCLLWLILVYDDPVSHPWISSPEKEYILSSLDQQFNSEEQPLPIKAMLKSLPLWSMCLCSMTHQWLVNTLIIYTPTYISSVFKVNIRDNGLLSSLPFFVAWVIGILGGLLADFLLSKNFRLITVRKIITILGNTPPAALVVALPYVQSSYIATTTFLTLSCGLSPLCQSGVYINALDIAPRYASLLMGTSRGLAHSSAVMVPIVAGFFLNQDSEFGWRNFFFVLFAINLFGLIIYLVFAKADIQEWARERKLTRL
Protein: Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5) (Q96L50)
Organism: Homo sapiens (Human)
Function: Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1.
Subcellular location: Nucleus {ECO:0000269|PubMed:34700328}.
Interaction partners:
- Cullin-2
- E3 ubiquitin-protein ligase RBX1
- Elongin-C
- Elongin-B
- DNA replication licensing factor MCM7
- WD repeat and HMG-box DNA-binding protein 1
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM5
- Cell division control protein 45 homolog
- DNA replication complex GINS protein SLD5
Sequence:
MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRYELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKGFLSAMRLAHRGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGCYVNSSDMLK
Protein: Calcium-regulated heat stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) (Q9CR86)
Organism: Mus musculus (Mouse)
Function: Binds mRNA and regulates the stability of target mRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21078874}. Cytoplasm, P-body {ECO:0000269|PubMed:21078874}. Cytoplasmic granule {ECO:0000269|PubMed:21078874}. Note=Detected at cytoplasmic stress granules and P-bodies. Detected at exosome granules where mRNA is degraded.
Interaction partners:
Sequence:
MSSEPPPPPLQPPTHQTSVGLLDTPRTRDRSPSPLRGNVVPSPLPTRRTRTFSATVRASQGPVYKGVCKCFCRSKGHGFITPADGGPDIFLHISDVEGEYVPVEGDEVTYKMCSIPPKNEKLQAVEVVITHLAPGTKHETWSGHVISN
Protein: Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1) (P56565)
Organism: Mus musculus (Mouse)
Function: Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P23297}. Sarcoplasmic reticulum {ECO:0000269|PubMed:3276520}. Mitochondrion {ECO:0000269|PubMed:17438143}.
Interaction partners:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- Annexin A2
- Ryanodine receptor 2
- Protein S100-B
- Toll-like receptor 4
Sequence:
MGSELESAMETLINVFHAHSGQEGDKYKLSKKELKDLLQTELSGFLDVQKDADAVDKVMKELDENGDGEVDFKEYVVLVAALTVACNNFFWETS
Protein: Uncharacterized protein Rv1518 (P9WLV9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Conserved hypothetical transmembrane protein
- Uncharacterized protein Rv1520
- Transferase
- Probable sugar transferase
- Alpha-pyrone synthesis polyketide synthase-like Pks18
- Probable 6-phosphogluconate dehydrogenase,decarboxylating Gnd2
- Uncharacterized protein Rv1525
Sequence:
MVPGDASSVVSVNPAKPLISVCIPMYNNGATIERCLRSILEQEGVEFEIVVVDDDSSDDCAAIAATMLRPGDRLLRNEPRLGLNRNHNKCLEVARGGLIQFVHGDDRLLPGALQTLSRRFEDPSVGMAFAPRRVESDDIKWQQRYGRVHTRFRKLRDRNHGPSLVLQMVLHGAKENWIGEPTAVMFRRQLALDAGGFRTDIYQLVDVDFWLRLMLRSAVCFVPHELSVRRHTAATETTRVMATRRNVLDRQRILTWLIVDPLSPNSVRSAAALWWIPAWLAMIVEVAVLGPQRRTHLKALAPAPFREFAHARRQLPMAD
Protein: Cytochrome c oxidase subunit 2 (Q9G1G3)
Organism: Sus scrofa (Pig)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000457}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000457}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004225}.
Interaction partners:
Sequence:
MAYPFQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPALTVKTMGHQWYWSYEYTDYEDLTFDSYMIPTSDLKPGEMRLLEVDNRVVLPMEMTIRMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLYYGQCSEICGSNHSFMPIVLELVPLKYFEKWSTSMLTGSL
Protein: Monomethylamine methyltransferase MtmB1 (MMA methyltransferase 1) (MMAMT 1) (EC 2.1.1.248) (O30642)
Organism: Methanosarcina barkeri
Function: Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC (MtmC1 or MtmC2).
Interaction partners:
Sequence:
MTFRKSFDCYDFYDRAKVGEKCTQDDWDLMKIPMKAMELKQKYGLDFKGEFIPTDKDMMEKLFKAGFEMLLECGIYCTDTHRIVKYTEDEIWDAINNVQKEFVLGTGRDAVNVRKRSVGDKAKPIVQGGPTGSPISEDVFMPVHMSYALEKEVDTIVNGVMTSVRGKSPIPKSPYEVLAAKTETRLIKNACAMAGRPGMGVOGPETSLSAQGNISADCTGGMTCTDSHEVSQLNELKIDLDAISVIAHYKGNSDIIMDEQMPIFGGYAGGIEETTIVDVATHINAVLMSSASWHLDGPVHIRWGSTNTRETLMIAGWACATISEFTDILSGNQYYPCAGPCTEMCLLEASAQSITDTASGREILSGVASAKGVVTDKTTGMEARMMGEVARATAGVEISEVNVILDKLVSLYEKNYASAPAGKTFQECYDVKTVTPTEEYMQVYDGARKKLEDLGLVF
Protein: TRAP dicarboxylate transporter, DctP subunit, putative (Q5LQQ5)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
Interaction partners:
- TRAP dicarboxylate transporter, DctM subunit
- TRAP transporter small permease protein
- Transporter, LysE family
- Membrane protein, putative
- Transcriptional regulator, GntR family
Sequence:
MRWVFQIWYTKKKLIVETLLASVLADGIPSLSARLAREPETAAIERRQGRRITMSLKFIYVAAGAAALAATTALADPVTLRVQTHYATEHPTGKQLAIWADDVQTMSGGDITIEMFYSSSVVATTETFDAAINGILDCDATGGAYQTGKNPAFQFVGDIMGGYDTPWQQYSWLYFGDGYAAAQELYNAQNMQLIGWAIYGQESLSSSKPIRGFEDLKGWKFRSPPGMETEIFEKLGASPIVMDFTEIFTALETGIIDGADASGLYNNVGLGLYDIVKHATYPGFHSMPSDHLACNLDVWNGLTDQQRRIVDTAWQKLGFQIALSNELNNNAAAAKLRAEGVTLHNWSAEDRAEFRKAAQAAWDDWGTRSPEAGALLASHKSYLTQLGLLN
Protein: Serum response factor (SRF) (Q9JM73)
Organism: Mus musculus (Mouse)
Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:19350017}.
Interaction partners:
- Myocardin
- Myocardin-related transcription factor A
- ETS domain-containing protein Elk-4
- Transcription factor GATA-4
- Homeobox protein Nkx-2.5
- ETS domain-containing protein Elk-1
- Nuclear factor of activated T-cells, cytoplasmic 3
- Nuclear factor of activated T-cells, cytoplasmic 1
- Nuclear factor of activated T-cells, cytoplasmic 4
- Nuclear factor of activated T-cells, cytoplasmic 2
Sequence:
MLPSQAGAAAALGRGSALGGNLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGQSRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMELGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLADGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE
Protein: Transcription elongation factor Spt5 (Q57818)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Stimulates transcription elongation.
Interaction partners:
- Large ribosomal subunit protein uL11
- Transcription elongation factor Spt4
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS8
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein uL30
Sequence:
MIFAVRTMVGQEKNIAGLMASRAEKEQLDVYSILASESLKGYVLVEAETKGDVEELIKGMPRVRGIVPGTIAIEEIEPLLTPKKIIENIEKGDVVEIIAGPFKGERAKVIRVDKHKEEVTLELENAAVPIPITLPVEGVKIVSKHKD
Protein: Protocadherin gamma-A4 (PCDH-gamma-A4) (Q91XY4)
Organism: Mus musculus (Mouse)
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O88689}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O88689}.
Interaction partners:
Sequence:
MAAPYKSDRRGLIWICIFLGSLCDIRAEQIRYSVPEELERGSVVGNLAADLGLEPGKLAERGVRIVSRGKTQLFALNPRSGSLVTAGRVDREGLCDRSPKCTANLEILLEDKVRILAIEVEIIDVNDNAPSFGAQQREIKVAESENPGTRFPLPEAFDLDIGVNALQGYQLSSNDHFSLDVQSGPDGIKYPELVLENALDREEEAVHHLVLTAFDGGDPVRSGTATIQVTLVDTNDNAPVFTQPEYHISVKENLPVGTRLLTIKATDPDEGVNGEVTYSFRNVREKISQLFQLNSLTGDITVLGELDYEDSGFYDVDVEAHDGPGLRARSKVLVTVLDVNDNAPEVTVTSLTSSIQEASSPGTVIALFNVHDSDSGENGLVTCSIPDNLPFRLEKTYGNYHRLLIHRTLDREEVSDYNITITATDQGTPPLSTETYISLQVVDINDNPPTFTHASYSAYIPENNPRGASILSITAQDPDSGENAQVIYSLSEDTIQGAPMSSYVSINSNTGVLYALRSFDYEQFQDLKLLVTARDSGTPPLSSNVSLSLSVLDQNDNTPEILYPTIPTDGSTGVELTPRSADPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVTVQDHGQPPLSATVTLTIAVSDNIPDILADLVNINAPIDQEDSDITLYLVVAVAAVSCVFLAFVIVLLIHRLRRWHSTRLLQAAGNGLSSLPASHFVGVDGVHAFLQTYSHEVSLTADSGKSHLIFPQPNYADTLISQESCGKSDPLLVSQDLLEIKGDSSLQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Protein: D-galactonate dehydratase (GalD) (EC 4.2.1.6) (Q6BF17)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
Interaction partners:
- 2-dehydro-3-deoxygalactonokinase
- 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
- Galactonate operon transcriptional repressor
- D-galactonate transporter
- Uncharacterized protein YjiH
- Uncharacterized protein YidR
Sequence:
MKITKITTYRLPPRWMFLKIETDEGVVGWGEPVIEGRARTVEAAVHELGDYLIGQDPSRINDLWQVMYRAGFYRGGPILMSAIAGIDQALWDIKGKVLNAPVWQLMGGLVRDKIKAYSWVGGDRPADVIDGIKTLREIGFDTFKLNGCEELGLIDNSRAVDAAVNTVAQIREAFGNQIEFGLDFHGRVSAPMAKVLIKELEPYRPLFIEEPVLAEQAEYYPKLAAQTHIPLAAGERMFSRFDFKRVLEAGGISILQPDLSHAGGITECYKIAGMAEAYDVTLAPHCPLGPIALAACLHIDFVSYNAVLQEQSMGIHYNKGAELLDFVKNKEDFSMVGGFFKPLTKPGLGVEIDEAKVIEFSKNAPDWRNPLWRHEDNSVAEW
Protein: Zinc finger protein 76 (Zinc finger protein 523) (Q8BMU0)
Organism: Mus musculus (Mouse)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MESLGLQTVRLSDGTTAYVQQAVKGEKLLEGQVIQLEDGTTAYIHQVTIQKESFSFEDGQPVQLEDGSMAYIHHTPKEGCDPSALEAVQLEDGSTAYIHHPVPVPSDSAILAVQTEAGLEDLAAEDEEGFGTDTVVALEQYASKVLHDSPASHNGKGQQVGDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSSCGKTYRQTSTLAMHKRSAHGELEATEESEQALYEQQQLEAASAAEESPPPKPTHIAYLSEVKEESSAIPTQVAMVTEEDGPPQVALITQDGTQQVSLSPEDLQALGSAISVVTQHGSTTLTIPGHHEELATSGTHTVTMVSADGTQTQPVTIITSGALVTEDSSVASLHHQQVALLATANGTHIAVQLEDQQTLEEAISVATAAMQQGAVTLETTESGC
Protein: UV-induced protein uvi31 (BolA-like protein 1) (Q12238)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoyl synthase (LS) and succinate dehydrogenase (SDH). Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein. Probably acts together with the monothiol glutaredoxin grx5. Not required for [2Fe-2S] cluster insertion into mitochondrial proteins (By similarity). May be involved in control of cell division, especially during the resumption from cell cycle arrest.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q3E793}. Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized bolA-like protein C4B3.11c
- Uncharacterized bolA-like protein C8C9.11
- Monothiol glutaredoxin-5
- Monothiol glutaredoxin-4
- Lipid-anchored plasma membrane protein uvi15
- DASH complex subunit dad1
- Fe-S cluster assembly protein dre2
- Monothiol glutaredoxin-3
- Translin-1
- Protein-lysine N-methyltransferase rrg1
Sequence:
MIRRFFHTMGRQDRIYKTLSEALKTDKITLYNDSYKHSHHIAMKGVPDTNETHFRLEIVSPEFSGMSRVARHRLVYGLLKDEFDGGLHALQITSSKTPDEVS
Protein: Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN) (Q9NUL5)
Organism: Homo sapiens (Human)
Function: Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site. Regulates HIV1 GAG-POL expression by inhibiting -1PRF. Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Interrupts also Zika virus replication by promoting viral NS3 degradation via a lysosome-dependent pathway. Can also limit the replication of hepatitis C virus (HCV) by restricting formation of viral replication organelle, West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1), herpes virus type 8 (HHV-8) and human adenovirus. Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:32150556}. Nucleus {ECO:0000269|PubMed:26735137}. Cytoplasm, P-body {ECO:0000269|PubMed:27974568}. Note=Predominantly found in the cytoplasm (PubMed:26735137). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568). {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:27974568}.
Interaction partners:
- Helicase MOV-10
Sequence:
MSQEGVELEKSVRRLREKFHGKVSSKKAGALMRKFGSDHTGVGRSIVYGVKQKDGQELSNDLDAQDPPEDMKQDRDIQAVATSLLPLTEANLRMFQRAQDDLIPAVDRQFACSSCDHVWWRRVPQRKEVSRCRKCRKRYEPVPADKMWGLAEFHCPKCRHNFRGWAQMGSPSPCYGCGFPVYPTRILPPRWDRDPDRRSTHTHSCSAADCYNRREPHVPGTSCAHPKSRKQNHLPKVLHPSNPHISSGSTVATCLSQGGLLEDLDNLILEDLKEEEEEEEEVEDEEGGPRE
Protein: Apoptosis regulator Bcl-2 (P49950)
Organism: Rattus norvegicus (Rat)
Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P10415}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:P10415}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P10415}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P10417}.
Interaction partners:
- Bcl-2-like protein 11
- Beclin-1
- BCL2 interacting protein 3
- Cellular tumor antigen p53
- Bcl-2-like protein 1
- Phorbol-12-myristate-13-acetate-induced protein 1
- Bcl2-interacting killer, isoform CRA_a.
- Bcl2-associated agonist of cell death
- BCL2-antagonist/killer 1, isoform CRA_b.
- Apoptosis regulator BAX
Sequence:
MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDTGDEDSAPLRAAPTPGIFSFQPESNRTPAVHRDTAARTSPLRPLVANAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Protein: LD44530p (Q8MRH6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPPPPPSLTNNHNHETIDEEEEVVIRPKARVPAVVKSANAQGLTKEEIELRNLRKKTRKRTRKFEIDGVQMTTTTSRVIYGDDENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQDRRFEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIRLLKQEVDLFPKDKRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATINRNFLQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRMLQRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRYMQEERRFEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQLVPRKQVCMQIPV
Protein: Auxin efflux carrier component 3 (AtPIN3) (Q9S7Z8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a component of the auxin efflux carrier. Seems to be involved in the lateral auxin transport system and mediates tropic growth. Coordinated polar localization of PIN3 is directly regulated by the vesicle trafficking process.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20439545}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Auxin transporter protein 1
- Auxin transporter-like protein 3
- ABC transporter B family member 19
- L-tryptophan--pyruvate aminotransferase 1
- Protein TRANSPORT INHIBITOR RESPONSE 1
- ABC transporter B family member 4
- ABC transporter B family member 1
- Serine/threonine-protein kinase D6PK
- Serine/threonine-protein kinase WAG2
- Auxin transporter-like protein 2
Sequence:
MISWHDLYTVLTAVIPLYVAMILAYGSVRWWKIFSPDQCSGINRFVAIFAVPLLSFHFISTNNPYAMNLRFIAADTLQKIIMLSLLVLWANFTRSGSLEWSITIFSLSTLPNTLVMGIPLLIAMYGEYSGSLMVQIVVLQCIIWYTLLLFLFEFRGAKMLIMEQFPETAASIVSFKVESDVVSLDGHDFLETDAEIGDDGKLHVTVRKSNASRRSFCGPNMTPRPSNLTGAEIYSLSTTPRGSNFNHSDFYNMMGFPGGRLSNFGPADMYSVQSSRGPTPRPSNFEENCAMASSPRFGYYPGGGAGSYPAPNPEFSSTTTSTANKSVNKNPKDVNTNQQTTLPTGGKSNSHDAKELHMFVWSSNGSPVSDRAGLNVFGGAPDNDQGGRSDQGAKEIRMLVPDQSHNGETKAVAHPASGDFGGEQQFSFAGKEEEAERPKDAENGLNKLAPNSTAALQSKTGLGGAEASQRKNMPPASVMTRLILIMVWRKLIRNPNTYSSLIGLIWALVAFRWHVAMPKIIQQSISILSDAGLGMAMFSLGLFMALQPKLIACGNSVATFAMAVRFLTGPAVMAVAAIAIGLRGDLLRVAIVQAALPQGIVPFVFAKEYNVHPAILSTGVIFGMLIALPITLVYYILLGL
Protein: Protein EARLY RESPONSIVE TO DEHYDRATION 15 (GmERD15) (I1JIC4)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: DNA-binding protein that binds to the NRP-B promoter to activate the NRP-B-mediated cell death response. Functions as an upstream component of stress-induced NRP-B-mediated signaling to connect stress in the endoplasmic reticulum (ER) to an osmotic stress-induced cell death signal. Exhibits transactivation activity in yeast.
Subcellular location: Nucleus {ECO:0000269|PubMed:21482825}.
Interaction partners:
Sequence:
MEVISASSLNPNAPMFVPLAYRTVEDFSDQWWNLVHSSPWFRDYWLRECFQDPQFQNDDAFDFDFDLDLQDEDEKERKEGKEVVSLGVLKWRSCGGGWAQAPRYVEKAPKFVKPKVSPRAIHQPR
Protein: Cytochrome P450 71B31 (EC 1.14.-.-) (Q9SCN2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- S-
- Butyrate--CoA ligase AAE11, peroxisomal
- CASP-like protein 2A2
- Germin-like protein subfamily 1 member 4
- GDSL esterase/lipase At5g37690
- At2g15020
- Calcium-dependent protein kinase 25
Sequence:
MSMFLGLLFLFPLFFILFKNLLPPRKKLPPGPTGLPLIGNLHQLGRLLHSSLHKLSLEHGPVMLVRWGVVPMAVFSSNEAAKEVLKTHDLETCNRPKLVANGLFTHGYKDIGFTQYGEEWREMKKFVGLELFSPKKHKSFRYIREEEGDLLVKKISNYAQTQTLVDLRKSLFSYTASIIFREAFGQNFRECDYINMDKLEELVQETETNVCSLAFTDFFPRGLGWLVDRISGQHSRMNIAFSKLTTFFEDVIDELLKTKQLDDHSDLVTAMLDVINRPRKFGSLKITYDHLIAMMSDVVLAGVNAGTVTMIWTMTELTRHPRVMKKLQEEIRATLGPNKERITEEDLEKVEYLNLVIKESFRLHPPAPLLLPRETMSDIEIQGYHIPKNAHVKINTYAIGRDPKRWTNPEEFNPERFLNTSINYKGQHYELLPFGAGRRNCPGMTLGITILELGLLNILYYFDWSLPSGMTIKDIDMEEDGALNIAKKVPLQLVPTLP
Protein: Fructose-1,6-bisphosphatase (EC 3.1.3.11) (Q90Z73)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
PLDGSSNIDCLVSIGTIFAIYRKTTDDEPNERDALQSGRHIVAAGYALYGSATMMVLSTGQGVNCFMLDPSIGEFILTDKDVKIKKRGKIYSLNEGFAQHFYPDVTEYLKKKKYPEDGSAPYGGRYVGSMVA