wanglab/gogpt-training-data huggingface dataset:
Protein: Syntenin-2 (Similar to TACIP18) (SITAC) (Syndecan-binding protein 2) (Q9H190)
Organism: Homo sapiens (Human)
Function: Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15961997}. Nucleus, nucleolus {ECO:0000269|PubMed:15961997, ECO:0000269|PubMed:23300061}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23300061}. Cell membrane {ECO:0000269|PubMed:15961997}. Nucleus speckle {ECO:0000269|PubMed:15961997}. Note=Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061). {ECO:0000269|PubMed:11102519, ECO:0000269|PubMed:15961997, ECO:0000269|PubMed:23300061}.
Interaction partners:
- CD63 antigen
- Syndecan-1
- Programmed cell death 6-interacting protein
- CD9 antigen
- CD81 antigen
- Tumor susceptibility gene 101 protein
- Tetraspanin-7
- T-cell differentiation antigen CD6
- Protein unc-93 homolog B1
Sequence:
MSSLYPSLEDLKVDQAIQAQVRASPKMPALPVQATAISPPPVLYPNLAELENYMGLSLSSQEVQESLLQIPEGDSTAVSGPGPGQMVAPVTGYSLGVRRAEIKPGVREIHLCKDERGKTGLRLRKVDQGLFVQLVQANTPASLVGLRFGDQLLQIDGRDCAGWSSHKAHQVVKKASGDKIVVVVRDRPFQRTVTMHKDSMGHVGFVIKKGKIVSLVKGSSAARNGLLTNHYVCEVDGQNVIGLKDKKIMEILATAGNVVTLTIIPSVIYEHMVKKLPPVLLHHTMDHSIPDA
Protein: Tripeptidyl peptidase 2 (A0A494C1S6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTKLDSSDIYNELKETYPNYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHTQAQDGAISTDAEGKEEEG
Protein: Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (P51841)
Organism: Homo sapiens (Human)
Function: Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).
Subcellular location: Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:O02740}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Guanylyl cyclase-activating protein 1
- Guanylyl cyclase-activating protein 2
- Guanylyl cyclase-activating protein 3
- Retinal guanylyl cyclase 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Bis
- Pyruvate kinase PKM
- Pyruvate kinase PKLR
- Inosine triphosphate pyrophosphatase
Sequence:
MFLGLGRFSRLVLWFAAFRKLLGHHGLASAKFLWCLCLLSVMSLPQQVWTLPYKIGVVGPWACDSLFSKALPEVAARLAIERINRDPSFDLSYSFEYVILNEDCQTSRALSSFISHHQMASGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVGVVLTTGQDSQSMRKALQRIHQADRIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRNNPKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHSTYTVDMEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIALLSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRASVSFQITSEVQSGRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQVGHGLQPVEIAAFQRRKAERQLVRNKP
Protein: UGa8H (A2KUC3)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGERWLPSYYMDVWGQGTLVSVSS
Protein: Pyrimidine 5'-nucleotidase YjjG (EC 3.1.3.5) (House-cleaning nucleotidase) (Non-canonical pyrimidine nucleotide phosphatase) (Nucleoside 5'-monophosphate phosphohydrolase) (dUMP phosphatase) (P0A8Y1)
Organism: Escherichia coli (strain K12)
Function: Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6-phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non-canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine, 5-fluorouridine, 5-fluoroorotate, 5-fluorouracil, and 5-aza-2'-deoxycytidine, and prevents the incorporation of potentially mutagenic nucleotides into DNA. Its dUMP phosphatase activity that catalyzes the hydrolysis of dUMP to deoxyuridine is necessary for thymine utilization via the thymine salvage pathway. Is strictly specific to substrates with 5'-phosphates and shows no activity against nucleoside 2'- or 3'-monophosphates.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- 5'-deoxynucleotidase YfbR
- GMP/IMP nucleotidase YrfG
- 5'/3'-nucleotidase SurE
- Uridine phosphorylase
- Protein UshA
- Guanosine-inosine kinase
- Thymidine phosphorylase
- Uridine kinase
- Thymidine kinase
- Thymidylate synthase
Sequence:
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHGRFESWAERLNVEPGKLNEAFINAMAEICTPLPGAVSLLNAIRGNAKIGIITNGFSALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYALEQAGNPDRSRVLMVGDTAESDILGGINAGLATCWLNAHHREQPEGIAPTWTVSSLHELEQLLCKH
Protein: Trishanku (Q54D84)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Required for normal morphogenesis and cell-type stability.
Interaction partners:
- UBX domain-containing protein 7 homolog
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL22m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein uL4m
Sequence:
MEIEPVVRISFNGNNNQNNNNNNNNNTNNNSNNNNNNNNSSNINSTNKPSVKKPINQKMISNINNQKSPNPLNSSVDDNNNTNNNNNSNSNGTDEDIIKLARDLTNTFGILLGDSDQPSQFSDVIFKVGDRKFFASKIMLVARSEYFKAMFTGSMKESSIKEITLEGVDPDVFFTVLKYICIGILDLDYDHRMVSSIYQYCDLLGLQRGKELSLATMGKIAQMYLEKPDVESALFLWDSLNQSAIPVESVHPHLRAFVLQYASISLHCDAFYSISLTTLVQMLRNDGLRMEELDILDCVIDWCRENSQASIQQQQQQQQQQLQSANGASGKSHGKRSSSSHLKKHDGDGGSDGSCSSRCSSRRNSLSLKDHHRQHIGNGGGGGGHYNNNDCHSDTEETYSDIDDEEHRNGGGGVGDDFENDSEDGDDDDEDDDEDDDFTDDDDKDDSANDDYEYSTNKDDLDIIEDWDTTIDKNLLDEVLPLIRWENMNIGEAFERLDNLKIIPDKEISNLLRHILKSNRGESFSFLGYHYRRPRNNRKRPYPIEFLLGITQPFDSNVTNEIIPLNSFSSEFGQSTNQFLYRIKKDIKLPANLERFSFKDREFFVQLKEREKGQLAVYLAFGSKLTKPLAISVLASVIGFRFQDSIEFSFKKMFDEGFDSAWGWPKFISLDTLYKQDKYSHYSDSFCLLIELTSQWG
Protein: Putative S-adenosyl-L-methionine-dependent methyltransferase Rv1729c (EC 2.1.1.-) (P9WFH9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Interaction partners:
- Glycoside hydrolase
- Conserved protein
Sequence:
MARTDDDNWDLTSSVGVTATIVAVGRALATKDPRGLINDPFAEPLVRAVGLDLFTKMMDGELDMSTIADVSPAVAQAMVYGNAVRTKYFDDYLLNATAGGIRQVAILASGLDSRAYRLPWPTRTVVYEIDQPKVMEFKTTTLADLGAEPSAIRRAVPIDLRADWPTALQAAGFDSAAPTAWLAEGLLIYLKPQTQDRLFDNITALSAPGSMVATEFVTGIADFSAERARTISNPFRCHGVDVDLASLVYTGPRNHVLDYLAAKGWQPEGVSLAELFRRSGLDVRAADDDTIFISGCLTDHSSISPPTAAGWR
Protein: Sugar transporter ERD6-like 7 (P93051)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sugar transporter.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Vacuolar ATPase assembly integral membrane protein VMA21 homolog
- At1g20770
- Bidirectional sugar transporter SWEET17
Sequence:
MSKASDAVREPLVDKNMAGSKPDQPWMVYLSTFVAVCGSFAFGSCAGYSSPAQAAIRNDLSLTIAEFSLFGSLLTFGAMIGAITSGPIADLVGRKGAMRVSSAFCVVGWLAIIFAKGVVALDLGRLATGYGMGAFSYVVPIFIAEIAPKTFRGALTTLNQILICTGVSVSFIIGTLVTWRVLALIGIIPCAASFLGLFFIPESPRWLAKVGRDTEFEAALRKLRGKKADISEEAAEIQDYIETLERLPKAKMLDLFQRRYIRSVLIAFGLMVFQQFGGINGICFYTSSIFEQAGFPTRLGMIIYAVLQVVITALNAPIVDRAGRKPLLLVSATGLVIGCLIAAVSFYLKVHDMAHEAVPVLAVVGIMVYIGSFSAGMGAMPWVVMSEIFPINIKGVAGGMATLVNWFGAWAVSYTFNFLMSWSSYGTFLIYAAINALAIVFVIAIVPETKGKTLEQIQAIVNP
Protein: Myocyte enhancer factor 2B (Similar to Myocyte-specific enhancer factor 2B, isoform CRA_a) (Q6AXR7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Myocyte-specific enhancer factor 2A
- Myocyte-specific enhancer factor 2D
- Calcineurin-binding protein cabin-1
- Nuclear factor of activated T-cells, cytoplasmic 3
- Nuclear factor of activated T-cells 2
- Nuclear factor of activated T-cells, cytoplasmic 4
- Nuclear factor of activated T-cells 1
- Homeobox protein Nkx-2.5
- Myogenin
- Histone deacetylase
Sequence:
MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCDIALIIFNSAQRLFQYASSDMDRVLLKYTEYSEPHESRTNADILQTLKRRGVGLDGPELDMEEGPEGPGEKLLRTLGGDRGLVSPPPRIYPVAPAMSVSELSYRVPPATSGCDPGGLGEAPSVHSRSPHFRPPGLGHPIFSPSHLAGKTPPPLYLATDGRRPDLPPGLVGARGGLGTSRSLYSGLQSPGAPGPALGSFAFLPPGSADCSPGDAAQVPLQPSPWPPTRDAVDPAGPAARSLCEEGPPSREASPPTPPVSIKSERLSPVTGTSGDFPRSFPYPLLLARPLAEPLRPASLRRLTPDSWPR
Protein: Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) (Q9Z339)
Organism: Rattus norvegicus (Rat)
Function: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Subcellular location: Cytoplasm, cytosol.
Interaction partners:
- Glutathione S-transferase theta-2
- Glutathione S-transferase alpha-3
- Hematopoietic prostaglandin D synthase
- Glutathione S-transferase Mu 1
- Glutathione S-transferase kappa 1
- Glutathione S-transferase Mu 5
- Glutathione S-transferase theta-1
- Glutathione S-transferase
- Glutathione S-transferase P
- Glutathione S-transferase Mu 7
Sequence:
MSGASARSLGKGSAPPGPVPEGQIRVYSMRFCPFAQRTLMVLKAKGIRHEIININLKNKPEWFFEKNPFGLVPVLENTQGHLITESVITCEYLDEAYPEKKLFPDDPYEKACQKMTFELFSKVPSLVTSFIRAKRKEDHPGIKEELKKEFSKLEEAMANKRTAFFGGNSLSMIDYLIWPWFQRLEALELNECIDHTPKLKLWMATMQEDPVASSHFIDAKTYRDYLSLYLQDSPEACDYGL
Protein: T-box transcription factor TBX5 (T-box protein 5) (Q5I2P1)
Organism: Rattus norvegicus (Rat)
Function: DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q99593, ECO:0000255|PROSITE-ProRule:PRU00201}. Cytoplasm {ECO:0000250|UniProtKB:Q99593}. Note=Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-338 promotes nuclear retention. {ECO:0000250|UniProtKB:Q99593}.
Interaction partners:
- Homeobox protein Nkx-2.5
- Transcription factor GATA-4
- Catenin beta-1
- Transcriptional coactivator YAP1
- Heart- and neural crest derivatives-expressed protein 2
- Myocyte-specific enhancer factor 2C
- Myosin-6
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Myocardin
Sequence:
MADADEGFGLARTPLEPDSKDRSCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRQMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDLELHRMSRMRSKEYPVVPRSTVRHKVANHSPFSSETRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLAQEHSQIYHCTKRKDEECSSTEHPYKKPYMETSPSEEDTFYRSGYPQQQGLSTSYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVTHQPVVRQCGPQTGLQSPGSLQPPEFLYTHGVPRTLSPHQYHSVHGVGMVPEWSENS
Protein: Geminin DNA replication inhibitor (E2QRF9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNPSMKQKQEEIKENIKNSSVPRRTLKMIQPSASGSLVGRENELSAGLSKRKHRNDHLTSTTSSPGVIVPESSENKNLGGVTQESFDLMIKENPSSQYWKEVAEKRRKALYEALKENEKLHKEIEQKDNEIARLKKENKELAEVAEHVQYMAELIERLNGEPLDNFESLDNQEFDSEEE
Protein: Akap9 protein (Q4G046)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
RLQGIMQEFQKQELEPEEKRGSRGLVYQNLNEPASWTFTDDRTRNWVLQQKMGETKDTNFTKLIEINGELDHNHDLEVIRQTLQHVASKLQHVAQKACNRLQFETASDDAFIWIQENIDGIILQLQKLTGQPGDEHSLAPPSSSCGSLTESLMRQNTELTRLINQLTEEKNTLRSIVVKLEELNRCHWHTGAGRDCCSRFSFIDPADIEAIIASEKEVWNREKLSLQKALKRAEAKVYKLKAELRNDALLRSLSPDSEHAALQKIYNKYLRASSFRKALIYQKKYLLLLLGGFQECEDATLGVLARMGGHPALKDPKTITSHPKGFTRFRSAVRVSIAISRMKFLVRRWQQVTSTSSININRDGFGLSPGIEKTDPFYHSSGGLELYGEPRHTTYRSRFDLDYPRSPLPLQNRYPGAPDLNSTSMASSQLHQYNPDKSLTDYVTRLEALKRRLGAIQSGSTTQFHFGMRR
Protein: Phosphotransferase (EC 2.7.1.-) (Q8L5G8)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
MVKAVVVGAAVVACAAVGVAVVLERRRRKRDADLLGSAEAERRRRAAAVIEEVESSLATPTALLRGIADAMVAEMERGLRGDIHAQLKMLISYVDSLPTGDEHGLFYALDLGGTNFRVLRVQLGGKEKRVVKQQYEEVSIPPHLMVGTSMELFDFIAAALAKFVGTEGEDFQLPEGRQRELGFTFSFPANQTSISSGTLIKWTKGFSINGTVGEDVVSELSRAMERQGLDMKVTALVNDTVGTLAGGRYMDNDVVAAVILGTGTNAAYVEHANAIPKWTGLLPKSGNMVINTEWGSFKSNKLPLSEYDKAMDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHEASLFGDVVPPKLELPFILRTPDMAAMHHDSSHDLKTLGAKLKDIVGVADTSLEVRYITRHICDLVAERAARLAAAGVYSILKKIGRDKVPSGGGKMPRTVVALDGGLYEHYKKFSSCVEATLTDLLGEEASSSVVAKLANDGSGIGAALLAASHSQYQYGASD
Protein: 3-oxoadipate CoA-transferase (EC 2.8.3.6) (Q9I2B0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- 3-oxoadipate CoA-transferase
- Acetyl-CoA acetyltransferase
- 3-hydroxybutyrate dehydrogenase
- 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase
- Probable AMP-binding enzyme
- Probable 3-hydroxyacyl-CoA dehydrogenase
- Fatty acid oxidation complex subunit alpha
- Probable acyl-CoA thiolase
- Probable acyl-CoA thiolase
- DhcR, transcriptional regulator
Sequence:
MSGLDKRVGSYEEALEGLTDGMTVLAGGFGLCGIPENLIAEIRRRGVRDLTVVSNNCGVDGFGLGVLLEDRQIRKMIASYVGENALFEQQLLSGELEVELTPQGSLAEKIRAGGAGIPAFFTATGYGTPVAEGKEAREFNGRHYILEPAITGDFAIVKGWKADHFGNVVYRHTAQNFNPLVATAGRITVVEVEEIVEPGELDPTQIHTPGIYVDRIIQGRFEKRIEKRTLRA
Protein: Interleukin-17 receptor E (IL-17 receptor E) (IL-17RE) (Q8BH06)
Organism: Mus musculus (Mouse)
Function: Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.
Interaction partners:
- Interleukin-17C
- Interleukin-17 receptor A
- Interleukin-17 receptor B
- Interleukin-25
- Interleukin-17 receptor D
- Interleukin-17F
- Interleukin-17 receptor C
- Interleukin-17B
- Interleukin-17A
- Interleukin 17D
Sequence:
MGSPRLAALLLSLPLLLIGLAVSARVACPCLRSWTSHCLLAYRVDKRFAGLQWGWFPLLVRKSKSPPKFEDYWRHRTPASFQRKLLGSPSLSEESHRISIPSSAISHRGQRTKRAQPSAAEGREHLPEAGSQKCGGPEFSFDLLPEVQAVRVTIPAGPKASVRLCYQWALECEDLSSPFDTQKIVSGGHTVDLPYEFLLPCMCIEASYLQEDTVRRKKCPFQSWPEAYGSDFWQSIRFTDYSQHNQMVMALTLRCPLKLEASLCWRQDPLTPCETLPNATAQESEGWYILENVDLHPQLCFKFSFENSSHVECPHQSGSLPSWTVSMDTQAQQLTLHFSSRTYATFSAAWSDPGLGPDTPMPPVYSISQTQGSVPVTLDLIIPFLRQENCILVWRSDVHFAWKHVLCPDVSHRHLGLLILALLALTALVGVVLVLLGRRLLPGSGRTRPVLLLHAADSEAQRRLVGALAELLRTALGGGRDVIVDLWEGTHVARIGPLPWLWAARERVAREQGTVLLLWNCAGPSTACSGDPQAASLRTLLCAAPRPLLLAYFSRLCAKGDIPRPLRALPRYRLLRDLPRLLRALDAQPATLASSWSHLGAKRCLKNRLEQCHLLELEAAKDDYQGSTNSPCGFSCL
Protein: Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) (Q96ST8)
Organism: Homo sapiens (Human)
Function: Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.
Subcellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Mitochondrion intermembrane space. Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane.
Interaction partners:
- Sodium channel and clathrin linker 1
- Centrosomal protein of 83 kDa
- Fas-binding factor 1
- Centrosomal protein of 164 kDa
- Ninein
- Leucine-rich repeat-containing protein 45
- Centrosomal protein 15
- C2 domain-containing protein 3
- Centrosomal protein of 128 kDa
- Rab-3A-interacting protein
Sequence:
MLLGFRRGRRSHFKHIIHGLLPAASVAPKAAVPRTPPPRSPNPSPERPRSALAAAILATTLTGRTVAIPQPRQRSRSESDVSSVEQDSFIEPYATTSQLRPRPNWQSEMGRRSSLPSFETLDYGDEEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENISHQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQDNPRALVAPSLNGVSQADLLDGCDVCSYDLKSHAPTC
Protein: Zinc finger protein WIP5 (WIP-domain protein 5) (AtWIP5) (Q8W031)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcriptional regulator.
Subcellular location: Nucleus {ECO:0000269|PubMed:20541552}.
Interaction partners:
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform
- Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform
- Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform
- Stress up-regulated Nod 19 protein
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform
Sequence:
MSNPACSNLFNNGCDHNSFNYSTSLSYIYNSHGSYYYSNTTNPNYINHTHTTSTSPNSPPLREALPLLSLSPIRHQEQQDQHYFMDTHQISSSNFLDDPLVTVDLHLGLPNYGVGESIRSNIAPDATTDEQDQDHDRGVEVTVESHLDDDDDHHGDLHRGHHYWIPTPSQILIGPTQFTCPLCFKTFNRYNNMQMHMWGHGSQYRKGPESLRGTQPTGMLRLPCFCCAPGCKNNIDHPRAKPLKDFRTLQTHYKRKHGSKPFACRMCGKAFAVKGDWRTHEKNCGKLWYCSCGSDFKHKRSLKDHVKAFGNGHVPCGIDSFGGDHEDYYDAASDIEQ
Protein: Beta-1,3-galactosyltransferase 7 (EC 2.4.1.-) (Q6NQB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal glycosyl residue.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18548197}; Single-pass type II membrane protein {ECO:0000269|PubMed:18548197}.
Interaction partners:
- Hydroxyproline O-galactosyltransferase GALT2
- Beta-1,6-galactosyltransferase GALT29A
- Probable fucosyltransferase 4
- Fucosyltransferase 6
- Beta-glucuronosyltransferase GlcAT14C
- Beta-glucuronosyltransferase GlcAT14B
- Beta-arabinofuranosyltransferase RAY1
- Hydroxyproline O-galactosyltransferase GALT5
- Beta-glucuronosyltransferase GlcAT14A
- Probable xyloglucan galactosyltransferase GT14
Sequence:
MKHKVSKRVISLKWVPFLCISFFALGAIFTSRSWEPSSDSGSQLISQHHRDHELQIVSDDCAHNKKATQEKDVTGEVLRTHEAIQDDRSLDKSVSTLSSTRSSQEMVDGSETNPRKKVFMVMGINTAFSSRKRRDSVRETWMPQGEKLERLEQEKGIVIKFMIGHSATSNSILDRAIDSEDAQHKDFLRLEHVEGYHELSAKTKIFFSTAVAKWDAEFYIKVDDDVHVNLGMLASTLARHRSKPRVYIGCMKSGPVLAQNLLNCFRTVKYHEPEYWKFGEDGNKYFRHATGQIYAISKDLANYISINQPILHKYANEDVSLGSWFIGLEVEHIDDRNFCCGTPPDCRWKAEAGDVCVASFEWSCSGICKSVERMKIVHEVCSEGEGAVWNTLL
Protein: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (F4JAD4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 2-oxoglutarate
Sequence:
MSNSESYPPEFRPLMSEKSTETGLDRSKDIDIPVIDMEHLDMEKLREACKDWGIFHLENTGIPLTFMSQVKEITESVLSLPFEEKRTLFGVNSPLSYYWGTHTVSPSGKAVTRAPQESSGHLFEGINIPLASLSRLLALSCTDPKLESFRVVMEEYGKHVTRIIVTLFEAIIETLSLELSGDQKMGYLSESTGVIRVQRYPQCTESPGLEAHTDSSVISIINQDDVGGLEFMKDGEWFNVKPLASSFVVGLGDMMQVISDEEYKSVLHKVGKRMRKKERYSIVNFVFPDKDCMFNSTRYKPFKFSEFEAQVKLDVETHGSKVGLSRFLSNP
Protein: GTPase Der (GTP-binding protein EngA) (F4KFX1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Short integuments 2, mitochondrial
- Glucose-inhibited division family A protein
- Pseudouridine synthase family protein
- At4g38020 family protein)
- Protein Iojap-related
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL24c
- Protein disulfide-isomerase 5-like protein
- Protein disulfide-isomerase 5-4
Sequence:
MSQSLVRAISARKNQFSLVFYYRCLYSKLLHSQDQIIASNCSNFSSLGFNSTVRHRSHQNRFCSNLISDLNLVRSTNGFATVSDESNVDNGEKLVDKKPKIFYKKPIDFTKIDANLLPTVMLMGRPNVGKSALYNRLIRRREALVYNTPDDHVTRDIREGIAKLGDLRFNVLDSAGIETEVSSGTILGRTTAMTANVLARTQFAVLIIDVRAGLHPLDLEVGKWLRKHAPQIKPIVVMNKSESIGSLDEVASEALALGFGEPIAISAETGLGMTTLYEVLRPLLEDYTVEMLNDIGSQDDVLTDENLSDEIDESKLPLQLAIVGKPNVGKSTLLNALLEEERVLVGPEAGLTRDAVRVQFEFQGRTVYLVDTAGWLERTERDKGPASLSIMQSRKSLMRAHVIALVLDAEEIIKAKCSMTHSEVVIARRAVEEGRGLVVIVNKMDRLRGRENSEMYKKIKEAVPIEIQTVIPQITGIPVVFISALEGRGRMEVMKEVTDTYKRWCSRLSTGRLNRWLRKVMSRHSWKDTASQPKIKFFTQVKARPPTFVAFVSGKTQLLESDIRFLTRSLKEDFDLGGTPIRIIQRVIPRAPPSGTGGGGSGNSSSRVVQRTTSDKRTLSA
Protein: Solute carrier family 40 member 2 (Ferroportin-2) (Iron-regulated transporter 2) (AtIREG2) (F4KGN5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Vacuolar transporter that is involved in the transport of excess nickel into the vacuole under iron deficiency, increasing cellular tolerance to nickel under iron deficiency stress response.
Subcellular location: Vacuole membrane {ECO:0000305|PubMed:16790430}; Multi-pass membrane protein {ECO:0000305|PubMed:16790430}. Note=Tonoplast.
Interaction partners:
- Metal tolerance protein A2
- Fe
- Fe
- Metal transporter Nramp4
- Putative inactive cadmium/zinc-transporting ATPase HMA3
- Putative metal tolerance protein C3
- Metal transporter Nramp3
- Probable nicotianamine synthase 4
- Nicotianamine synthase 2
- Ferric reduction oxidase 2
Sequence:
MEEETETRVFLSNEQHQEEEEEEEEEPSLPRSMVISLYLGYFLARWGARTWEFSVALYMIYLWPNSLFLTAMYGVVESGSATLFGPIVGQMIDGMSYVKVLRLWLVTQNLSFIVAGGAVVALLVVPDLKSQNFPVFATLVVLTNLSGAIGVLSTLAGTVLIERDWVVVMSEGHSPAVLTRMNSVIRGIDLSSKLLSPVITGLIISFVSLRASAITFAAWATITVWIEYWLFISVYNGVPAIVQSDERRSLRSSQSQAEETDSASSFYVPLLHEEESYRNTQSRSRILRILERISESSFVSAWRNYLNQEIVLPGVSLALLFFTVLSFGTLMTATLEWKGIPTYIIGIGRGISAGVGLAATVLYPLMQSRISPLRTGVWSFWSQWTCLLVCVGSIWVEKEKIASYMLMAGVAASRLGLWMFDLAVIQQMQDLVPESDRCVVGGVQNSLQSALDLMANLLGIIVSNPKDFWMLTLISFATVSLAGILYTIHLYRIRKHLFHLEKIPLLNNFFAS