wanglab/gogpt-training-data huggingface dataset:
Protein: Agamous-like MADS-box protein AGL8 (Floral homeotic protein AGL8) (Transcription factor FRUITFULL) (Q38876)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1 and CAULIFLOWER. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Seems to be partially redundant to the function of APETALA1 and CAULIFLOWER in the up-regulation of LEAFY. Is also required for normal pattern of cell division, expansion and differentiation during morphogenesis of the silique. Probably not required for fruit elongation but instead is required to prevent ectopic activity of IND. Represses SAUR10 expression in stems and inflorescence branches.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Protein LEAFY
- Squamosa promoter-binding-like protein 3
- Protein TERMINAL FLOWER 1
- B3 domain-containing transcription factor VRN1
- BEL1-like homeodomain protein 9
- Squamosa promoter-binding-like protein 4
- Protein TWIN SISTER of FT
- Squamosa promoter-binding-like protein 5
- MADS-box protein AGL24
- MADS-box protein SOC1
Sequence:
MGRGRVQLKRIENKINRQVTFSKRRSGLLKKAHEISVLCDAEVALIVFSSKGKLFEYSTDSCMERILERYDRYLYSDKQLVGRDVSQSENWVLEHAKLKARVEVLEKNKRNFMGEDLDSLSLKELQSLEHQLDAAIKSIRSRKNQAMFESISALQKKDKALQDHNNSLLKKIKEREKKTGQQEGQLVQCSNSSSVLLPQYCVTSSRDGFVERVGGENGGASSLTEPNSLLPAWMLRPTTTNE
Protein: SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4) (Q6S5L8)
Organism: Homo sapiens (Human)
Function: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Subcellular location: Postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.
Interaction partners:
- Epidermal growth factor receptor
- Growth factor receptor-bound protein 2
- Receptor tyrosine-protein kinase erbB-2
- Insulin-like growth factor 1 receptor
- Receptor tyrosine-protein kinase erbB-3
- Receptor tyrosine-protein kinase erbB-4
- BDNF/NT-3 growth factors receptor
- High affinity nerve growth factor receptor
- Proto-oncogene tyrosine-protein kinase Src
- Fibroblast growth factor receptor 3
Sequence:
MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPALLHSNK
Protein: Cytoplasmic polyadenylation element binding protein 1 (A0A024R214)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSWKSSLPTFFCHIYSFFHDFLYWLCGKSVKSCTTSGNSFFKQEFIILGMMAFMDFSVTMMALSLEEEAGRIKDCWDNQEAPALSTCSNANIFRRINAILDNSLDFSRVCTTPINRGIHDHLPDFQDSEETVTSRMLFPTSAQESSRGLPDANDLCLGLQSLSLTGWDRPWSTQDSDSSAQSSTHSVLSMLHNPLGNVLGKPPLSFLPLDPLGSDLVDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSLSGGGPRDPLKMGVGSRMDQEQAALAAVTPSPTSASKRWPGASVWPSWDLLEAPKDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGNMPKGYVYLVFELEKSVRSLLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVRSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVSAAFVEIKTTKFTKKVQIDPYLEDSLCHICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGLRHHSPLMRNQKNRDSS
Protein: Nudix hydrolase 2 (AtNUDT2) (EC 3.6.1.-) (ADP-ribose pyrophosphatase) (EC 3.6.1.13) (NADH pyrophosphatase) (EC 3.6.1.22) (Q94B74)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. In vitro, it can use both NADH and ADP-ribose as substrates; however the relevance of such substrates in vivo is unclear. Confers tolerance to oxidative stress.
Interaction partners:
- Nudix hydrolase 1
- Nudix hydrolase 4
- Nudix hydrolase 11
- Mediator of RNA polymerase II transcription subunit 7b
- Nudix hydrolase 25
- Nudix hydrolase 9
- Tapetum-specific protein A9
- At5g27290
- Flowering-promoting factor 1-like protein 2
- Flowering-promoting factor 1-like protein 1
Sequence:
MSASSSSTNPMSREDATTLLPSVQDKYGGVMTEMTHPMDPSLFSTLLRSSLSTWTLQGKKGVWIKLPKQLIGLAETAVKEGFWFHHAEKDYLMLVYWIPKEDDTLPANASHRVGIGAFVINHNKEVLVVQEKTGRFQGQGIWKFPTGVVNEGEDIHDGSVREVKEETGVDTEFDQILAFRQTHKAFFGKSDLFFVCMLKPLSLEINAQESEIEAAQWMPWEEYINQPFVQNYELLRYMTDICSAKTNGDYEGFTPLRVSAPDQQGNLYYNTRDLHSRN
Protein: Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344) (Q28113)
Organism: Bos taurus (Bovine)
Function: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (By similarity). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.
Interaction partners:
- 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
- Alpha-
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
- Hexosyltransferase.
- Hexosyltransferase.
- CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
- Beta-1,4-galactosyltransferase 1
- Hexosyltransferase
Sequence:
MFSTQTFFFFPTAPFILFVFTASTIFHLHQRLEKMQPTWELEALEPATMETPSRPQPRPQLKGMWTINAIGRLGNQMGEYATLYALAKMNGRAAFIPPQMHSTLAPIFRITLPVLHDATARSVPWQNYHLNDWMEEQYRHIPGEYVRLTGYPCSWTFYHHLRAEILQEFTLHAHVREEAQNFLRGLRVNGSRPSTYVGVHVRRGDYVHVMPNVWKGVVADRRYLEQALDWFRARYSAPIFVVSSNGMAWCRENINASRGDVVFAGNGNEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGETIYLANYTLPDSPFLKIFKPEAAFLPKWIGIPADLSPLLKH
Protein: Probable calcium-binding protein CML25 (Calmodulin-like protein 25) (Q9FYK2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- Probable calcium-binding protein CML21
- At2g03740
Sequence:
MFNKNQGSNGGSSSNVGIGADSPYLQKARSGKTEIRELEAVFKKFDVNGDGKISSKELGAIMTSLGHEVPEEELEKAITEIDRKGDGYINFEEFVELNTKGMDQNDVLENLKDAFSVYDIDGNGSISAEELHEVLRSLGDECSIAECRKMIGGVDKDGDGTIDFEEFKIMMTMGSRRDNVMGGGPR
Protein: Biofilm PGA synthesis protein PgaD (P69432)
Organism: Escherichia coli (strain K12)
Function: Required for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide. May assist the glycosyltransferase PgaC in the polymerization of PGA.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
- Poly-beta-1,6-N-acetyl-D-glucosamine synthase
- Poly-beta-1,6-N-acetyl-D-glucosamine export protein
- Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase
Sequence:
MNNLIITTRQSPVRLLVDYVATTILWTLFALFIFLFAMDLLTGYYWQSEARSRLQFYFLLAVANAVVLIVWALYNKLRFQKQQHHAAYQYTPQEYAESLAIPDELYQQLQKSHRMSVHFTSQGQIKMVVSEKALVRA
Protein: Phosphodiesterase (EC 3.1.4.-) (F7ES56)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAQQQSAACQQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTRNFDAEAVCRSIRATNPSEHTVILAVVSQASDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDSSKQIHRIHRDSGDNSQTEPHSFRHKSRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHHSHSHLSMPITINDVPPSIAQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAAESEGSDCECNPTGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSNS
Protein: Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141) (P15306)
Organism: Mus musculus (Mouse)
Function: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Subcellular location: Membrane {ECO:0000250|UniProtKB:P07204}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P07204}.
Interaction partners:
- Prothrombin
- Vitamin K-dependent protein C
- Endothelial protein C receptor
- Tissue factor
- Tissue factor pathway inhibitor
- Coagulation factor VII
- Carboxypeptidase B2
- Antithrombin-III
- Complement factor H
- Coagulation factor XI
Sequence:
MLGIFFLGVLAPASLGLSALAKLQPTGSQCVEHECFALFQGPATFLDASQACQRLQGHLMTVRSSVAADVISLLLSQSSMDLGPWIGLQLPQGCDDPVHLGPLRGFQWVTGDNHTSYSRWARPNDQTAPLCGPLCVTVSTATEAAPGEPAWEEKPCETETQGFLCEFYFTASCRPLTVNTRDPEAAHISSTYNTPFGVSGADFQTLPVGSSAAVEPLGLELVCRAPPGTSEGHWAWEATGAWNCSVENGGCEYLCNRSTNEPRCLCPRDMDLQADGRSCARPVVQSCNELCEHFCVSNAEVPGSYSCMCETGYQLAADGHRCEDVDDCKQGPNPCPQLCVNTKGGFECFCYDGYELVDGECVELLDPCFGSNCEFQCQPVSPTDYRCICAPGFAPKPDEPHKCEMFCNETSCPADCDPNSPTVCECPEGFILDEGSVCTDIDECSQGECFTSECRNFPGSYECICGPDTALAGQISKDCDPIPVREDTKEEEGSGEPPVSPTPGSPTGPPSARPVHSGVLIGISIASLSLVVALLALLCHLRKKQGAARAELEYKCASSAKEVVLQHVRTDRTLQKF
Protein: 26S proteasome non-ATPase regulatory subunit 13 homolog A (26S proteasome regulatory subunit RPN9a) (AtRNP9a) (26S proteasome regulatory subunit S11 homolog A) (Q8RWF0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome regulatory subunit 6A homolog A
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome regulatory subunit 7 homolog A
- 26S proteasome non-ATPase regulatory subunit-like protein
- 26S proteasome regulatory subunit 7 homolog B
- 26S proteasome non-ATPase regulatory subunit 7 homolog A
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- 26S proteasome non-ATPase regulatory subunit 1 homolog A
Sequence:
MAALQYLESLKNTHPELGEWYNSLADLYQKKLWHQLTLKLEQFIALAVFQAGDALIQFYHNFITDFETKINLLKLAHFAVVVSRQYSEKEAAVSYLESVIEKLRATKEPRITEPIIYIETQKALFKLEQGDQKECKKILDDGKSSLDSMTDIDPSVYANFYWVSSQYHKCRQEFSDFYKSALLYLAYTSVEDLSESFKLDLAFDLSLSALLGENIYNFGELLAHPILKSLLGTNVEWLYHILQAFNHGDLVQYQELCRVHNASLIAQPALVENEKKLLEKINILCLIEIIFSRPAEDRTIPLSIIAERTKLSIEDVEHLLMKSLSVHLIEGIIDQVNGTIYVSWAQPRVLGIPQIKALRDQLDSWVDKVHTTLLSVEAETPDLVAA
Protein: Possible methyltransferase (Methylase) (P96395)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible transcriptional regulatory protein NadR
Sequence:
MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSRLDEWENVIAGRIAEATS
Protein: Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) (P28572)
Organism: Rattus norvegicus (Rat)
Function: Sodium- and chloride-dependent glycine transporter. Essential for regulating glycine concentrations at inhibitory glycinergic synapses (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16181645}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glycine receptor subunit alpha-1
Sequence:
MAVAHGPVATSSPEQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGDFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
Protein: VeA-like protein (Q4WKM3)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Velvet domain-containing protein
- Secondary metabolism regulator laeA
- Developmental and secondary metabolism regulator veA
Sequence:
MYAVEERSHPVPPPPPPLSMDRIPPPSSAYPTPGSAGPMRSADHLAPVSTIHEGRIWSLQVVQQPIRARMCGFGDKDRRPITPPPCIRLIVRDAQTEKEIDINEIDTSFYVLTVDLWNADGTSEVNLVKHSATSPSISTAMSSSYPPPPQNLSPTYPAFTQNPYGQPVGYPQMNNYYGGNAQLAYQYGTNPQASYYPPYYAGGQMPPAGMSPAQQPVPAGPGGMFTRNLIGSLSASAFRLTDPDNKIGVWFILQDLSVRTEGTFRLKMSFVNVGTQSGDSTNNTPVINHGSAPVLASVFSEPFQVFSAKKFPGVIESTQLSKCFALQGIKIPIRKDGVKGPRGRGGDGDDDADDYE
Protein: LD44245p (SoxNeuro, isoform A) (Q9VLH8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLTMESDMKGSLLHATMPPHHTSAALHGHAASPYSALAPLMNLGQSHLTHSQLSHHNHHHHHMSAHIAASQSPNPLSSLQSSMANTLNGSQVGQQQQQQQQQQSSPLHSSSELSPTQSSIGSHHMTSPVSHQQHTQQQQHGQQQHLGAGSALSSLTGGSSNNNNNSATANKNQQHADRVKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLTKTKEKYPMGGLMPGQTVGGGAPGEPVTPTRVQGQPGQNQSLNGSGGSAAAAAAAAAAAAQQARQDMYQMNAPNGYMPNGYMMHADPAGAAAYQTSYMGQHYAAQRYDMGHMYNNGYAMYQTVSGGQTSPYGSSLQQPGSPSPYGGSSLQQQPGSPTPYGGGGGGGGQVSCQSHSPSDSSIKSEPVSPSPSAIALNNNNNINNNHIMKREYSSAAAAAAAAAAAAAAGGGELNHLMNMYHLPDEQRHLLHYQTDSPDLQQQHQSMQQQQQHLPQQHLSQQHQQIPQQHHTMQQQQQQHHLQHQQSLRAMAPLAHM
Protein: Nicotinic acetylcholine receptor subunit gamma (G1FMP9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MDQNLSSKIIWLWILLFRFSGALCNLEGSLHRDLMVGYNKNIRPVESHGDIIDVKIKMTLTNLISLNEKEETLTTCVWIEMQWRDYRLRWANRTGLEVYENITRMRLPSKTIWLPDIGLENNVDGRFEVALYANTLIDPDGSVYWLPPAIYRSSCAIKVNYFPFDWQNCSMVFRSQTYNSNEITLMLSDEDNVTMEWIEIDPEAFTENGEWMIKHRPAKKVINKRYRPDELEHQEIIFFLIIQRKPLFYVINIIVPCVLFSSLGLLVYFLPAKAGGQKCTMTICILLGQTVFLFLIAKKVPETSQAVPLIGKYLMFVMSVTTITVMNCVVVLNVSLRTPNTHPMSNTIRKVLLNILPRVLRMTMQRWTPEQEEGDFKMFALGNGTPLRRRRRSSLGLIAKADEYMFRTARSELMFSRLKERKGLLKNTLEKIQNGLGGNTAQDLECSLAAASPEVQQCVSSCKHIAESTKHQNDFQSKNEEWFLVARVIDRMCFFVMALLFILGTIGIFLTGHFNQAPSQPFPGDPKKYLPEISAGDIPG
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 (A0A8I6A5E1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAVRKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLDFKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIVKRHQGTISEDKSNASHVVYPAPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWILDTDTFNEWMNEEDYEVSDDKSPVSRRKKISAKTLTDEVNSPDADRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPSTPYTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQDDESMETTGKDEDENSTGNKGEQTKSADLHEDNVTEQTHHIIVPSYAAWFDYNSVHAIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTPSGLVPLQPKPPQGRQVDADTKAGRKGKELDDLVPEAAKGKPELQGSASQQMLNFPDKGKEKPADMQNFGLRTDMYTKKNIPSKSKAAASATREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEASLGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTASDEPERIEESGTEEARAESQAADEKKEPKEPREGGGAVEEEAKEEISEAPKKDEEKGKEADSEKESEKSDGDPIVDPEKDKEPTEGQEEGLKEVAEPEGERKAKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRARQQHFQQMQQQPPPPPPPPPPPALPPGSQPIPPTGAAAPATVHGLAVAPASVASAPPGGGAPPGTLGPSEQIGQAGTTAGPQQPQQAGAPQPGAVPPGVPPPGPHGPSPFPNQQTPPSMMPGAVPGSGHPGVAGNAPLGLPFGLPLPPPAAPSIIPFGSLADSISINLPPPNLHGHHHLPFAPGTIPPPNLPVSMANPLHPNLPATTTMPSSLPLGPGLGSAAAQSPAIVAAVQGSLLPSASPLPDPGTPLPPDPTAPSPGTVTPVPPPQ
Protein: Flavin-dependent halogenase armH4 (EC 1.14.19.-) (ArmH4) (A0A0U3AL34)
Organism: Armillaria mellea (Honey mushroom) (Agaricus melleus)
Function: Flavin-dependent halogenase involved in the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols. The halogenase catalyzes the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product. The enzyme acts on free substrate and does not depend on carrier-protein-dependent acceptor molecules. Can also catalyze the transfer of a single bromine atom to the melleolide backbone in vitro.
Interaction partners:
Sequence:
MSSLLPPHAQILVVGGGPAGSYCASILAREGFSVVVLEATTFPRYHIGESMLPSVRPFLKFSGADNKIASHGFCPKPGAAVKFQQHKREGYTDFSTLSSGNSPDNAAAWNVKRSEFDEILLRHAEELGAQVFENHRVINLIFADNNVSEGRPISAEFSCPNGELRSISFDYLVDASGRAGIMSTKYLKNRKFNNTLRNVASWGYWTGAKRYMPGSERDNAPFFEALTDGSGWAWFIPLHDSTVSVGIVTDQASSTARKALSARNGMHCSSKADYLAQLKLAPTVSGKFLCKATLQGENSPTCIRSASDFSYAADRYSGDHFRLIGDASAFIDPFFSSGVHLALLGALTAAASISASIRKTCSELRAAQFHDKKVAIAYTRFLLVVMGVYKQIRNQDLHILAEVDEDNFDRAFDILRPVIQGTADVGKTVSEDELQKTMDFCKDIFAPTDPQMHEAVGARLGPELCSPSVPIMTDSEIEDLTKDDNEAKLVLKEINARKAVHTMYGGPIHVAAESIDGLVLNLEVGNFGLKNVH
Protein: Calcineurin subunit B type 1 (Calcineurin regulatory subunit 1) (Protein phosphatase 2B regulatory subunit 1) (Q55G87)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Important for stalk formation.
Interaction partners:
- Serine/threonine-protein phosphatase 2B catalytic subunit
- Uncharacterized protein
- FK506-binding protein 1
- Serine/threonine-protein phosphatase 2A catalytic subunit A
- Serine/threonine-protein phosphatase 4 catalytic subunit
- Probable serine/threonine-protein kinase roco11
- Probable serine/threonine-protein kinase qkgA
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase roco6
Sequence:
MGNQHSLLNKEQLEQMKDNSSFSEAELKKLYRRFQMLDKDGSGTLTTDEFLSIPDLALNPLLERVIQIFDQNKDNEIEFFEFVGTLATLSHKGTKEDKLKFLFQIYDIDCDGFISNGELFQVLKMMVGTNLNDVQLQQIVDKTIIEGDYDKDGKISFDEFIHMIGNQEGIEEKLSVNWSE
Protein: vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.17.4.4) (I3L3B4)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
Sequence:
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQGS
Protein: MAGE family member D2 (Melanoma antigen family D, 2, isoform CRA_d) (Q5H907)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSDTSESGAGLTRFQAEASEKDSSSMMQTLLTVTQNVEVPETPKASSTTQLTDTQVLAAENKSLAADTKKQNADPQAVTMPATETKKVSHVADTKVNTKAQETEAAPSQAPADEPEPESAAAQSQENQDTRPKVKAKKARKVKHLDGEEDGSSDQSQASGTTGGRRVSKARRRAAKLQSSQEPEAPPPRDVALLQGRANDLVKYLLAKDQTKIPIKRSDMLKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYILLSTLEPTDAGILGTTKDSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGIHHSLFGDVKKLITDEFVKQKYLDYARVPNSNPPEYEFFWGLRSYYETSKMKVLKFACKVQKKDPKEWAAQYREAMEADLKAAAEAAAEAKARAEIRARMGIGLGSENAAGPCNWDEADIGPWAKARIQAGAEAKAKAQESGSASTGASTSTNNSASASASTSGGFSAGASLTATLTFGLFAGLGGAGASTSGSSGACGFSYK
Protein: Lipoxygenase (EC 1.13.11.-) (Q9LKL4)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
MFGNIGKIPIIGDLTGSNKNAHLKGNVVLVRKTVLGLDVTSIAGSLLDGIGEFLGRGVTCQLISSTVVDPNNGNRGKLGAEASLEQWLLNPPPLLSSENQFRVTFDWEVEKQGIPGAIIVKNNHASEFFLKTITLNDVPGHGTIVFVANSWIYPQSKYRYNRVFFSNDTYLPSQMPAALKPYRDDELRNLRGDDQQGPYQEHDRVYRYDVYNDLGLPDSGNPRPVLGGTKELPYPRRCRTGRKPTKSDPNSESRLTLVDGDVYVPRDERFGHIKKSDFYGYAIKALVNAVIPAIRTYVDLSPGEFDSFKDIMKLYEGGIQLPKIPALEDLRKQFPLELVKDVLPVGGDYLLKLPMPQIIKEDKTGWMTDEEFGREILAGVNPMLVKRLTEFPPRSSLDPSKYGDHTSTIREADLENKLEGLTVQQALHGNRLYILDHHDNFMPFLVRVNSLEGNFIYATRTVLFLRGDGTLVPVAIELSLPELRDGLTTAKSTVYTPKSTTGAEAWVWHLAKAYANVNDYCWHQLISHWLNTHAVMEPFVIATNRQLSVTHPVHKLLLPHYRDTMNINSNARQMLVNAGGIFETTVFPRQYAFEMSSVIYKDWNFTEQALPDDLIKRGMAVADPSSPYKVRLLVEDYPYASDGLAIWHAIEQWVTEYLAVYYPNDGVLRADVELQAWWKEAREVGHADLKDAPWWPKMQTVAELVKACTTIIWIASALHAAVNFGQYPYAGYLPNRPSVSRKPMPAPGSDEYAELERKPEKVFVRTITSQFQALVGISLLEILSSHSSDEVYLGQRDTKEWTSDAKAQEAFKRFGARLTEIEKRVVTMNADPRLKNRNGPAEFPYTLLYPNTSDTKGDAAGITAKGIPNSISI
Protein: Lysozyme g (EC 3.2.1.17) (R4UMR3)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Interaction partners:
Sequence:
MAGIFGDVTKIDTTGASEITAKQDKLTVKGVEASNKLAEHDLKKMEQYKSIITKVGRAKKIDPAVIAGIISRESRAGAALVDGWGDHGNGFGLMQVDKRHHTPKGAWNSEEHVTQATEILIESIQAIQKKFPSWSKEHQLKGGISAYNAGPGNVRTYEKMDRGTTGDDYANDVVARSQWFKRNGY
Protein: DNA-binding protein HupB (HupB) (EC 1.16.3.1) (28 kDa iron-regulated protein) (Irep-28) (DNA-binding protein HU homolog) (Histone H1 homolog) (Histone-like protein) (HLPMt) (Hlp) (Nucleoid-associated protein HU) [Cleaved into: DNA-binding protein HupB, propeptide removed] (P9WMK7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Binds DNA non-specifically. Induces lymphoproliferation, particularly in health tuberculin reactors, and is immunogenic. Maybe involved in pathogenesis of inflammatory bowel disease (IBD) in patients with ulcerative colitis and Crohn disease (CD). Bound by anti-neutrophil cytoplasmic antibodies (pANCA), which are a hallmark of IBD. The binding is due to pANCA directed against H1-3 cross-reacting with DBH epitopes. In CD, target of a strong IgA response.
Subcellular location: Cytoplasm, nucleoid {ECO:0000305|PubMed:35521527}. Secreted, cell wall {ECO:0000269|PubMed:17028216, ECO:0000269|PubMed:33609202}. Note=Found along the cell length in a bead-like pattern (probably associated with DNA) (PubMed:35521527). Only seen in the cell wall when grown under low iron conditions (PubMed:33609202). {ECO:0000269|PubMed:33609202, ECO:0000269|PubMed:35521527}.
Interaction partners:
- Nucleoid-associated protein Lsr2
- Integration host factor
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein bS20
- Phenylalanine--tRNA ligase beta subunit
Sequence:
MGMNKAELIDVLTQKLGSDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFRPGAQFKAVVSGAQRLPAEGPAVKRGVGASAAKKVAKKAPAKKATKAAKKAATKAPARKAATKAPAKKAATKAPAKKAVKATKSPAKKVTKAVKKTAVKASVRKAATKAPAKKAAAKRPATKAPAKKATARRGRK
Protein: ATP-dependent RNA helicase (EC 3.6.4.13) (F6U6E2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTREL