wanglab/gogpt-training-data huggingface dataset:
Protein: G-protein coupled receptor 52 (P0C5J4)
Organism: Mus musculus (Mouse)
Function: G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (By similarity). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum. Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- G protein-coupled receptor 88
Sequence:
MNESRWTEWRILNMSSSIVNVSEHHSCPLGFGHYSVEDVCIFETVVIVLLTFLIISGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLLVGVTCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIIMIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTCFIVCLLYAPAALVVCFTYFHIFKICRQHTKEINDRRARFPSHEVEASREAGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCVCAKDQEAQDPKPRRRANSCSI
Protein: Anon1A3 (Q9U4Q9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
GVENLPSVTEAKQNHVDEVKPISEEPGNSSEEVPKAEEPLKSSGETSENGAATETAAAPKEPASVMDVDEDETLVENTPSANKEKALDDEKEPEQKSEEHAAAVLESKEQNEPAKEPTPEPMEVDGSSKGSSDTAQVDTPAIENVSAAPETEAAAKTTESSNDVVEVATEGKETVLEVPAAEPKEAESTVESAEELTETSTVVVTEPKEAASSEEEPSKVVDSAEPKEAESNTDESATPVPIDVSTAPASNDVSKPLEIDTTLVKTADSPAKEPQEICEVKKAEINVNGEPKIVNSSVEVGENAAPKVCN
Protein: Small ribosomal subunit protein eS21 (40S ribosomal protein S21) (P05765)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P63220}. Cytoplasm {ECO:0000250|UniProtKB:P63220}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:P63221}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P63220, ECO:0000250|UniProtKB:P63221}.
Interaction partners:
- Small ribosomal subunit protein uS7
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein eS7
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Small ribosomal subunit protein uS3
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MQNDAGEFVDLYVPRKCSASNRIIAAKDHASIQMNVAEVDRSTGRFNGQFKTYGICGAIRRMGESDDSILRLAKADGIVSKNF
Protein: Sulfiredoxin-1 (EC 1.8.98.2) (Neoplastic progression protein 3) (Q9D975)
Organism: Mus musculus (Mouse)
Function: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BYN0}.
Interaction partners:
- Peroxiredoxin-1
- Peroxiredoxin-2
- Thioredoxin reductase 1, cytoplasmic
- Thioredoxin-dependent peroxide reductase, mitochondrial
- Peroxiredoxin-4
- NAD
- Glutamate--cysteine ligase regulatory subunit
- Thioredoxin
- Glutathione reductase, mitochondrial
- Glutamate--cysteine ligase catalytic subunit
Sequence:
MGLRAGGALRRAGAGPGAPEGQGPGGAQGGSIHSGCIATVHNVPIAVLIRPLPSVLDPAKVQSLVDTILADPDSVPPIDVLWIKGAQGGDYYYSFGGCHRYAAYQQLQRETIPAKLVRSTLSDLRMYLGASTPDLQ
Protein: Probable transcriptional repressor C1348.12 (G2TRT1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable transcriptional repressor of multidrug resistance genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
Interaction partners:
- Uncharacterized nucleolar protein C2C4.08
- UPF0612 protein C337.02c
- Uncharacterized protein C25H2.10c
- Uncharacterized mitochondrial carrier C12B10.09
- Uncharacterized transcriptional regulatory protein C11D3.11c
- Probable glutathione-independent glyoxalase hsp3104
- Putative alpha-ketoglutarate-dependent sulfonate dioxygenase
- Uncharacterized RNA-binding protein C57A7.13
- Clustered mitochondria protein homolog
- Probable oligoribonuclease
Sequence:
MHLSKASFLFDCSRFILNFHERCLKNGVRTKKACVICRSKKQKCDGQLPCLYCKKYEYQCAYEGQATSTCNSEASLFNDANFKIGSDYRSKRIKVVSDTNNNKEDGDGKLSFTQCNPRMDIHHEAENFTAMVPYYEPKKFRFFYENSAIVFPRIYVFIYFEEVHPIFSMFDQKAMEKKIQFLWDNKSTDSCSEYVVISVKGKLVEHITQVLESSLSTTILSSIQLTVCWVLRTIYLHATTRPHLSWIASSVSMHYAEIVGLHQEITAEYGTRGIELTNITTQMVEEDGPAYQLVLLFKIIMEYQIISEDSRFVYLQAFQRLDQLCDIHSPALVLLKATVCFHLYRNLFLARIKPFCVIVSILFSVIDRALESCKQLVSQRKAW
Protein: Exosome complex component 10 homolog (EXOS-10) (EC 3.1.13.-) (Cell death-related nuclease 3) (G5EBX6)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000269|PubMed:34365510, ECO:0000269|PubMed:36763670}. Nucleus, nucleolus {ECO:0000269|PubMed:34365510, ECO:0000269|PubMed:36763670}. Nucleus, nucleoplasm {ECO:0000269|PubMed:36763670}. Note=As a part of exosome complex, translocates from the nucleolus to nucleoplasm in response to cold-warm shock. {ECO:0000269|PubMed:36763670}.
Interaction partners:
- Exosome complex component RRP46 homolog
- Nuclear nucleic acid-binding protein C1D
- Putative exosome complex component RRP41
- Exoribonuclease phosphorolytic domain-containing protein
- mRNA transport homolog 4
- Exosome complex component CSL4 homolog
- Exosome complex component RRP4 homolog
- Ribosomal RNA-processing protein 42
- Exosome complex component RRP45
- Exosome complex component RRP40
Sequence:
MSGEESMPDEEQKQSEEEEEMIRKRTLAMRKKVEEIMRNGAGLVRESNGLPKAGADYELYNSYPTFNTFMKRSEQRLNALMNKVTKSIGCAMRVPDVGSSVEHYTECVIEAQDNIAERAATLHEALKKAELDEIVKVPEFITKAAPTNRKTEAEVSAAMRTFSANIGTVLAEKFRERREEAAQMVVLEKPQKTYNISSDNSQAPFSSKLTVKHHAIEKRTGIVLHDDDESGRRDWISAETETEEEHPYIAEILHFKVPEAQLKSAECLKFTALKDTPLTMIDTKEKLEALTKTLNSVKEFAVDLEHHQMRSYLGLTCLIQISTRDEDFIIDPFPIWDHVGMLNEPFANPRILKVFHGSDSDVLWLQRDYGVHVVNLFDTYVAMKKLKYPKFSLAYLTLRFADVVLDKQYQLADWRARPLRNAMINYAREDTHYLLYSYDMLREQLLKQDTKDLANVYSESSDLCIKVYKKPVFNPKGYLTEIKFRFTLNTRQDYALTHLFKWRDVVARAEDESPHFVLPNHMMLSLSETLPRDVGGIYACCNPLPYFVKQRTGDILKIIVEARDVKLEKVGLSAKERNDAQEARGVMNDTMDHITSVLKSKIDFSHTRFDEERGEIYIDKTDEGMDIELKDHKESLLSVLQTAEIPSVETMIVVEKGKKSDNQKVKKLLNELDKFVTPFECYQMMMITKEKQEEEERKEAERKKLEEGDLPKTMFSHHDAPINRKPEFDAKLLNVDTLKLVPDDPNKPKDPEPSPMEESSSEPQIFDPSRFTDDQLLSKKAMKRKRDAARRNIDVSVVLGESSSSSDPKKKKSDDDAPVEDFDYEKADSSAFEKPVRDNNADFDPFHQKYRLKNKTKKNMAMKKSSNRQGTINYKK
Protein: High mobility group protein B2 (High mobility group protein 2) (HMG-2) (P26584)
Organism: Gallus gallus (Chicken)
Function: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner (By similarity). Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:14672558}. Chromosome {ECO:0000305}. Cytoplasm {ECO:0000305}. Secreted {ECO:0000305}.
Interaction partners:
- High mobility group protein B1
- Non-histone chromosomal protein HMG-17
Sequence:
MGKGDPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSRKCSERWKTMSSKEKGKFEEMAKGDKARYDREMKNYVPPKGEKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKNDHPGLSIGDTAKKLGEMWSEQLAKDKQPYEQKAAKLKEKYEKDIAAYRAKSKSDAGKKGPGRPAGSKKKAEPEEEEEEEEDEEEEEEEEDEE
Protein: Ankyrin 2 (A0A5F9ZHR2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKSGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Protein: Prolactin-3D1 (Chorionic somatomammotropin hormone 1) (Placental lactogen I) (PL-I) (P18121)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted.
Interaction partners:
- Prolactin-7A1
- Trophoblast-specific protein alpha
- Placental lactogen-I gamma
- Placental lactogen-I beta
- Cathepsin Q
Sequence:
MQLTLNLSGSAGMQLLLLVSSLLLWENVSSKPTAMVPTEDLYTRLAELLHNTFILAADVYREFDLDFFDKTWITDRTLPLCHTASIHTPENREEVHETKTEDLLKAMINVSISWKEPLKHLVSALTALPGASESMGKKAADIKGRNLVILEGLQTIYNRSQANIEENENFDYPAWSGLEELQSPNEDTHLFAVYNLCRCIKRDIHKIDSYIKVLRCRVVFQNEC
Protein: C-X-C chemokine receptor type 4a (Chemokine (C-X-C motif) receptor 4a) (Q7ZU02)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early endosome {ECO:0000256|ARBA:ARBA00004412}.
Interaction partners:
Sequence:
MAYYGHIVFEDDLSADNSSEFGSGDIGANFEVPCDVEVSHDFQRIFLPTVYGIIFALGLIGNGLVVLVMGCQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDVAKDWYFGGFMCVAVHMIYTVNLYSSVLILAFISLDRYLAVVRATNSQGPRKLLANRIIYVGVWLPAALLTVPDLVFAKAESSAIRTFCERIYPQDSFVTWVVAFRFQHILVGFVLPGLVILICYCIIISKLSRGSKGTQKRKALKTTVVLIVCFFVCWLPYCGGILLDTLMMLEVIPHSCELEQGLQKWIFVTEALAYFHCCLNPILYAFLGVKFKKSARSALSPSRGSSLKILSKKRTGMSSVSTESESSSFHSS
Protein: MB2d protein (Q95552)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAALWLLLLVLSLHCMGAGGFVAHVESTCVLNDAGTPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISMILNEQESLIHRLQNGLQDCATHTQPFWDVLTHRTRAPSVRVAQTTPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH
Protein: Multiple C2 domain and transmembrane region protein 6 (Q9SKA3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:29259105}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:29259105}. Endosome membrane {ECO:0000269|PubMed:29259105}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- 16 kDa phloem protein 2
Sequence:
MNKLVVEIVDASDLMPKDGQGSASPFVEVEFDEQRQRTQTRFKDLNPQWNEKLVFNVGDLKRLNNKTVDVTVYDDRRDNQPGKFLGRVKIAGAVVPLSESESGVQRYPLDKRGLFSNIKGDIALRIYAAPIDGGDFVSPPPDFAEKVMKEDKRFESQEFQFQNQNQNQNHYEQFEDEINNMETLKPTKKKEKESRTFHSIGAHAGGGGGAPPMSQAKQAYPPPPNQPEFRSDFMRAPGPPTGAVMQMQPPRQQNPEFQLIETSPPLAARMRQSYYYRSSGDKTSSTYDLVEQMHYLYVSVVKARDLPVMDVSGSLDPYVEVKLGNYKGLTKHLEKNSNPIWKQIFAFSKERLQSNLLEVTVKDKDLLTKDDFVGRVHIDLTEVPLRVPPDSPLAPQWYRLEDKKGMKTNRGEIMLAVWMGTQADESFPDAWHSDAHRVSHSNLSNTRSKVYFSPKLYYLRIHVMEAQDLVPSDKGRVPDAIVKIQAGNQMRATRTPQMRTMNPQWHEELMFVVSEPFEDMVIVSVDDRIGPGKDEILGRVFIPVRDVPVRQEVGKMPDPRWFNLQRHSMSMEEENEKRKEKFSSKILLRVCIEAGYHVLDESTHFSSDLQPSSKHLRKPSIGILELGILSARNLMPMKGKDGRMTDPYCVAKYGNKWVRTRTLLDALAPKWNEQYTWEVHDPCTVITIGVFDNSHVNDGGDFKDQRIGKVRVRLSTLETDRVYTHFYPLLVLTPGGLKKNGELQLALRYTCTGFVNMMAQYGRPLLPKMHYIQPIPVRHIDLLRHQAMQIVATRLSRSEPPLRREVVEYMLDVDYHMFSLRRSKANFSRIMSLLSSVTLVCKWFNDICTWRNPITTCLVHVLFLILVCYPELILPTVFLYLFVIGMWNYRYRPRHPPHMDARVSQADNAHPDELDEEFDTFPTSRPADIVRMRYDRLRSVGGRVQTVVGDLATQGERIQALLSWRDPRATALFIVFALIWAVFIYVTPFQVIAIIIGLFMLRHPRFRSRMPSVPANFFKRLPAKSDMLL
Protein: Protein ced-11 (Cell death protein 11) (P34641)
Organism: Caenorhabditis elegans
Function: Plays a major role in programmed cell death.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- GTL-1
- Transient receptor ion channel domain-containing protein
- Ion_trans domain-containing protein
- CUP-5L
- TRP homologous cation channel protein
- Ion transport domain-containing protein
- J domain-containing protein
- Ion transport domain-containing protein
Sequence:
MDETDPVPDMSLLPDTVPVVVSGDGSAAGIQLCPALILGSPQALPGAIKHIYSRLAAAASEVDQGVPDLIISLISHGNSLSTKYMSSVENGLKSFLIGCGTWLISSGEVNDPMSRVASGALKNVLPQLEHQAEVLHILVNSDDMIASDTTNSKSVVDTSLNTLLLICRKEPNDSYETVASSIAKLRAATAVKLAHPPPALLIGVPSEPMSPSTYGNSAAILLSPSNDKRPFPVAIFAGASKESLIELLFFVEHGIPVIILQDSCELCAILHSSHLLLETSNFDNDKFISWLRSQLYPLGLADCYTLITKLLVSSNSGDVQLIEFIDSSQLSELSSVVVDRCLECYATTGEERQVLLLAAKLNSPSVLSSMDVAAQLDEELLTMILCECITKDDQLHFLSSVLQLSPPIRVTSNMLIRMMHHADEHFFTTIVLCQCMGYSYIPSEIDPRFANDIQKLVKKLSFGVDNLFDPNVFCNDSSHRDKHESIRILAIWSLLLHRPGIVKCLAAFADEPVAFSMVLSRIARSLGHESHDWHFYEKSLNTLSDSLSGSATTLFDTVFSTSPAKAYQLLCQPMEYFYGFNMTQLAFHCNAREIIAHECCQRWVHRKLYGNLQAKNFPIFLPKWAKICISAVLIIPVKFWMLVRPRERTKQDTVSPTVALLDVGKFPQKQRAISTYSVISSRSEALTALTAPLSTAFGFNSALNGAESATPQSMVFPLNIEEIDKDPRPFGKKNRIRRAHAPTLSTFYSTPIVKYWLSLLFRIVFICCLAYSVVLPGCGSNLWDTGMWVWSFFWWIENCFVLTARARKIPLSLMPWRVFDVFAFFVFLILLLVMKVFPVTPVLEVLGIDSIYSAKVVSAFFVLYVSYSTLFTYIPLSDIFGPMIVRVKLMLLRDFTNFLFMIALVMLSSAVAIQAVVFPDRPVTMEVFRKTLSWIWLSLFTTDLSNLSESETCRKSFLGAPKRYCSSVGQYANPSCPSQSLPAYLIVIEYFVILKLLLWPILFAFFSKTAKNVDDEADKIWRFQLYSLAEDFRLRPPLPPPLTIFCLICSACCRFSNSFSGFFSDFDHPDFEARDKCRTTWKFGSIYRNPSVPFKRNEFVNSFWRKLSMEQWKNTQQKAKISANKSELQELHNIHNHIRMMTLRDSYENSGTRKASELQFFEKYPESNILKISVNMVSKPWTVLVPRYNPPFYCKPAEDFPSDVQKYVDIATEQNVGELKRIWRSRQANDVTSSNDKCWKLSAAGFPLNPNGRTGMAGRGNHPRFGANRRCYYVVLSGGVEAKCQVLVDSQKNIPNEWHLENSSKDEHLTSILKMIGISDSDAHMFSMRRLDSSIITADKRIPSNDTSPAHLASEVAENENDTDNAWTEHDVWAISLRERRIITTIIGYSWLPTSAIRGTVLPWQADLVFRAKTIYGL
Protein: Uroporphyrinogen-III synthase (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) (P09126)
Organism: Escherichia coli (strain K12)
Function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
Interaction partners:
- Porphobilinogen deaminase
- Protein HemX
- Uroporphyrinogen decarboxylase
- Delta-aminolevulinic acid dehydratase
- Siroheme synthase
- Protein HemY
- Glutamyl-tRNA reductase
- Histidinol dehydrogenase
- Chorismate synthase
- N5-carboxyaminoimidazole ribonucleotide mutase
Sequence:
MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALSQHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHCRLLVVSERLAKLARELGWQDIKVADNADNDALLRALQ
Protein: Putative uncharacterized protein C19orf73 (Q9NVV2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRLKVGFQGGGCFRKDALCLEGGVSARWARAPHSAPLRPPRELHAAPPPATPTQTVVRPAGFPRRTRLMVRSAPPTQRPPTGSGCVSGLWRKGLGLRPQTLLRVGSVVLSSAPALRPRLGPCLRPPPSD
Protein: Small ribosomal subunit protein uS14 (40S ribosomal protein S29) (P62273)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6QAP6}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q6QAP6, ECO:0000269|PubMed:25957688}.
Interaction partners:
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL20
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL37
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL28
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein eL31
Sequence:
MGHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD
Protein: Homeobox protein Hox-D3 (Homeobox protein Hox-4A) (P31249)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-D4
- Homeobox protein Hox-D9
- Metaxin-2
- Homeobox protein Hox-D10
Sequence:
MLFEQGQQALELPECTMQKAAYYENPGLFGGYGYSKTTDTYGYSTPHQPYPPPAAASSLDTDYPGSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGSQPPGLNSEQQPPQPPPPPPTLPPSSPTNPGGGVPAKKPKGGPNASSSSATISKQIFPWMKESRQNSKQKNSCATAGESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPASQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMASNGGGFASANLQGSPVYVGGNFVESMAPASGPVFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQGRLPEAPKLTHL
Protein: Radixin (A0A8I5ZR70)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Interaction partners:
Sequence:
VPKKHYKVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLRQIEEQTMKAQKELEEQTRKALELEQERQRAKEEAERLDRERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMCAPPPPPPPAVVPPTENEHDEQDEHSAEASAELSSEGVTNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
Protein: Probable ribonuclease 11 (RNase 11) (EC 3.1.27.-) (Q8TAA1)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
METFPLLLLSLGLVLAEASESTMKIIKEEFTDEEMQYDMAKSGQEKQTIEILMNPILLVKNTSLSMSKDDMSSTLLTFRSLHYNDPKGNSSGNDKECCNDMTVWRKVSEANGSCKWSNNFIRSSTEVMRRVHRAPSCKFVQNPGISCCESLELENTVCQFTTGKQFPRCQYHSVTSLEKILTVLTGHSLMSWLVCGSKL
Protein: Sciellin (O95171)
Organism: Homo sapiens (Human)
Function: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
Subcellular location: Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase.
Interaction partners:
- Extracellular sulfatase Sulf-1
- Synaptopodin
- Protein YIPF3
- Cytochrome P450 26A1
Sequence:
MSNVTLRKMSPTGNEMKSTTQGTTRKQQDFHEVNKRRTFLQDNSWIKKRPEEEKDENYGRVVLNRHNSHDALDRKVNERDVPKATISRYSSDDTLDRISDRNDAAKTYKANTLDNQLTNRSMSMFRSLEVTKLQPGGSLNANTSNTIASTSATTPVKKKRQSWFPPPPPGYNASSSTGTRRREPGVHPPIPPKPSSPVSSPNQLRQDNRQIHPPKPGVYTETNRSAERNIRSQDLDNIVKVATSLQRSDKGEELDNLIKMNKSLNRNQGLDSLFRANPKVEEREKRAKSLESLIYMSTRTDKDGKGIQSLGSPIKVNQRTDKNEKGRQNLESVAKVNARMNKTSRRSEDLDNATEVNPKGHENTTGKKDLDGLIKVDPETNKNITRGQSLDNLIKVTPEVKRSNQGSKDLNNFIKVYPGTEKSTEGGQSLDSLIKVTPERNRTNQGNQDLENLIKVIPSANKSSEQGLDEHINVSPKAVKNTDGKQDLDKLIKVNPEIFTNNQRNQDLANLIKVNPAVIRNNQSQDLDNLIKVKPSALRNTNRDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVYSTSDRSVIERDMCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCYSKIMAKWIP
Protein: Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10) (Asparagine-linked glycosylation protein 10) (Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10) (P50076)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9597543}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dol-P-Man:Man
- Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Dol-P-Man:Man
- Dolichyl-phosphate beta-glucosyltransferase
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1
Sequence:
MDAKKNTGEANNDVLEEEAAIQLIAPGIARNLTQEVITGIFCNVVIYPLLLIYFVLTFRYMTTNIVPYEFIDEKFHVGQTLTYLKGKWTQWDPKITTPPGIYILGLINYYCIKPIFKSWSTLTILRLVNLLGGIIVFPILVLRPIFLFNALGFWPVSLMSFPLMTTYYYLFYTDVWSTILILQSLSCVLTLPFGPVKSIWLSAFFAGVSCLFRQTNIIWTGFIMILAVERPAILQKQFNTHTFNNYLKLFIHAIDDFSNLVLPYMINFVLFFIYLIWNRSITLGDKSSHSAGLHIVQIFYCFTFITVFSLPIWISRNFMKLYKLRIKRKPVQTFFEFIGIMLIIRYFTKVHPFLLADNRHYTFYLFRRLIGNKSRLIKYFFMTPIYHFSTFAYLEVMRPNQLTFHPITPLPIKEPVHLPIQLTHVSWTALITCTMVTIVPSPLFEPRYYILPYFFWRIFITCSCEPLIKDLKPAKEGENPITISSTKRLFMEFLWFMLFNVVTLVIFSKVSFPWTTEPYLQRIIW
Protein: fructose-bisphosphatase (EC 3.1.3.11) (Q9I8D3)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
INMLQSSYSTCVLVTEENKEALITPKEKRGKYVVCFDPLDGSSNIDCLAPIGTIFAIYKKETDDEPSEKDALQPGRKIVAAGYALYGSATLVALSTGQGVDCFMLDPALGEFILVDRDVKIKKKGKIYSLNEGYAKYFDPAMTEYLKKKKFPEDGSSPYGARYVGS
Protein: Putrescine-binding periplasmic protein PotF (P31133)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex PotFGHI involved in putrescine uptake. Binds putrescine. Imports putrescine for maintenance of the optimal concentration of polyamines necessary for cell growth in the presence of glucose.
Subcellular location: Periplasm {ECO:0000269|PubMed:8416922}.
Interaction partners:
- Putrescine transport system permease protein PotH
- Putrescine transport system permease protein PotI
- Putrescine transport ATP-binding protein PotG
- Spermidine/putrescine transport system permease protein PotC
- Spermidine/putrescine transport system permease protein PotB
- Inner membrane ABC transporter permease protein YdcV
- Spermidine/putrescine import ATP-binding protein PotA
- Inner membrane ABC transporter permease protein YdcU
- Uncharacterized ABC transporter ATP-binding protein YdcT
- Histidine-binding periplasmic protein
Sequence:
MTALNKKWLSGLVAGALMAVSVGTLAAEQKTLHIYNWSDYIAPDTVANFEKETGIKVVYDVFDSNEVLEGKLMAGSTGFDLVVPSASFLERQLTAGVFQPLDKSKLPEWKNLDPELLKLVAKHDPDNKFAMPYMWATTGIGYNVDKVKAVLGENAPVDSWDLILKPENLEKLKSCGVSFLDAPEEVFATVLNYLGKDPNSTKADDYTGPATDLLLKLRPNIRYFHSSQYINDLANGDICVAIGWAGDVWQASNRAKEAKNGVNVSFSIPKEGAMAFFDVFAMPADAKNKDEAYQFLNYLLRPDVVAHISDHVFYANANKAATPLVSAEVRENPGIYPPADVRAKLFTLKVQDPKIDRVRTRAWTKVKSGK