wanglab/gogpt-training-data huggingface dataset:
Protein: Protein transport protein Sec31A (SEC31-like protein 1) (SEC31-related protein A) (D6REX3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}.
Interaction partners:
Sequence:
MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSSSHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILAIAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQHSIVLPLKKPPKWIRRPVGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYRKEDLGKKIALALNKVDGANVALKDSDQVAQSDGEESPAAEEQLLGEHIKEEKEESEFLPSSGGTFNISVSGDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKITRLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQTQACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLLAAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPVAGHESPKIPYEKQQLPKGRPGPVAGHHQMPRVQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSDTQGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSASSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKVVLTQANKLGV
Protein: IP08061p (IP08161p) (IP08261p) (IP08361p) (Pasang lhamu) (Q9VN75)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- hydroxyacylglutathione hydrolase
Sequence:
MFRSLVNITSKYKVLRGMISYGTLWPCGSLIEQTMIEKKTFRTYDWMKCLRFSLFGFFFMGPTIYVWIRLASVMWPRTDIKSSLCKAITEQTAYDPMAISSFLFFMTLMEGNSYAEAKREVSDKFLDAYKVGVIYWPCVQTVNFAFVPARNQVVFTSFFSMCWTTFLAYVKFLQLHPPVDVDHHALDIHFLEM
Protein: Protein FAM3C (Interleukin-like EMT inducer) (Q92520)
Organism: Homo sapiens (Human)
Function: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
Subcellular location: Secreted {ECO:0000250}. Cytoplasmic vesicle {ECO:0000269|PubMed:16959614}. Note=Cytoplasmic in some cancer cells.
Interaction partners:
- Lysosome-associated membrane glycoprotein 1
- HLA class I histocompatibility antigen, C alpha chain
- Programmed cell death protein 1
Sequence:
MRVAGAAKLVVAVAVFLLTFYVISQVFEIKMDASLGNLFARSALDTAARSTKPPRYKCGISKACPEKHFAFKMASGAANVVGPKICLEDNVLMSGVKNNVGRGINVALANGKTGEVLDTKYFDMWGGDVAPFIEFLKAIQDGTIVLMGTYDDGATKLNDEARRLIADLGSTSITNLGFRDNWVFCGGKGIKTKSPFEQHIKNNKDTNKYEGWPEVVEMEGCIPQKQD
Protein: DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2) (Q02363)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P41136}. Nucleus {ECO:0000250|UniProtKB:P41136}.
Interaction partners:
- Transcription factor E2-alpha
- Transcription factor 4
- Transcription factor 12
- DNA-binding protein inhibitor ID-4
- Oligodendrocyte transcription factor 1
- Oligodendrocyte transcription factor 2
- Homeobox protein Nkx-2.5
- Myoblast determination protein 1
- Cyclin-dependent kinase 2
- Transcription factor GATA-4
Sequence:
MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG
Protein: 3-hydroxyisobutyryl-CoA hydrolase (HIB-CoA hydrolase) (HIBYL-CoA-H) (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (B9A058)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|RuleBase:RU369070}.
Interaction partners:
Sequence:
MLEEDLLALKSPSKENIASVLENYHTESKIDRDKSFILEEHMDKINSCFSANTVEEIIENLQQDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKSLGSSDLKF
Protein: Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) (P50391)
Organism: Homo sapiens (Human)
Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.
Subcellular location: Cell membrane {ECO:0000269|PubMed:7493937, ECO:0000269|PubMed:7592911}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRCLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI
Protein: Tubulin alpha chain (A9PL18)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Uncharacterized protein LOC107899987
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
Sequence:
MRECISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPSDKTVGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGAYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLVSQVISSLTASLRFDGALNVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTSVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESAEGDEGEDDEY
Protein: LOB domain-containing protein 27 (ASYMMETRIC LEAVES 2-like protein 29) (AS2-like protein 29) (Q9STS6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- LOB domain-containing protein 42
- LOB domain-containing protein 26
- Protein VAC14 homolog
- E3 ubiquitin-protein ligase APD1
Sequence:
MSNTKHIHKGLQERLLDLLLIALIVYMTLKGGTSGACAACKYQRRRCAADCPLAPYFPAEQPKLFQNVHRLFGVRSIVKILEKLDETQKPEAMKSIIFQSYVRDRSPVHGCLGVTQQLQYMIWFAEEELKAVNSQLQLYRSQPQNGQNQNQNHNHNQMIHELGSDHNKQQEDVTSQQLDLGMGLNVNNNQSNVVTPFFSSLLPVSETQQPQMSYTYSCSEVNNNGYSPPAYNTDSGKEILTNNNNVWGDQNRFLYNNNNGGGYSNQNESCHEMKSNGVMAIQSQLVNLQMVSNHQRVEEEEADHEYDELHQFLDIIDDRQSFGDSKEA
Protein: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) (H0YMU3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGPAWISKVSRLLGAFHNPKQVTRGFTGGAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANI
Protein: Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64) (C9JRZ8)
Organism: Homo sapiens (Human)
Function: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal. May play a physiological role in retinoid metabolism.
Subcellular location: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:25577493}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:25577493}.
Interaction partners:
Sequence:
MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQEKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFDFKEFSHLEDFPFDAEY
Protein: Autophagy-related protein 29 (C5DF24)
Organism: Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Subcellular location: Preautophagosomal structure {ECO:0000256|ARBA:ARBA00004329}.
Interaction partners:
- Autophagy-related protein 17
- KLTH0C07942p
- Autophagy-related protein 13
- Serine/threonine-protein kinase ATG1
- Autophagy-related protein 9
- non-specific serine/threonine protein kinase
Sequence:
MNSENTIVYVRVAGRARNGFVDPLKFYWDLERDRSLWSSVSKLDNTKKTIDWKRLSREFKAPEHFIRKRSYALFAKHLKLLERQIEAKTRSLAVTEDELNYTDEDDERNSISHGEDDFEAAEGLKNLRTSKVLKQRVPGEGRNGESSLSELSNLSVSKSALEEALLDRLQL
Protein: IST1 homolog (Charged multivesicular body protein 8) (H3BQF7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYL
Protein: Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase) (Q28GQ2)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro (By similarity). Functions in pronephros development, regulating late differentiation of all pronephric tubule segments.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9BV79}.
Interaction partners:
- Transmembrane protein 100.
- 3-oxoacyl-[acyl-carrier-protein] synthase
- Acyl-coenzyme A oxidase
- Uncharacterized protein
- Acyl-CoA dehydrogenase medium chain.
- Acyl-coenzyme A oxidase
- Uncharacterized protein.
- Uncharacterized protein.
- Protein phosphatase 3 regulatory subunit B, alpha.
- S-acyl fatty acid synthase thioesterase, medium chain
Sequence:
MWLGLRLFHRPFSSLAARGLVYEKHGEPLQVLRLKNVNITHPADNEVRVKMLAAPINPSDINMVQGTYALLPQLPAVGGNEGVGVVVEIGRHVSSMRPGDWVVPVDAGLGTWCTEAVFSEDSLVRVPSDIPVAGAATVSVNPCTAYRLLSDFETLRPGDTIIQNASNSGVGQAVIQIATSLGITTINVVRDREDLSSLIQRLRDLGADHVITEEQLRKPEMKDLFKNCPRPRLALNCVGGKSTTEMLRHLDYGGTMVTYGGMSKQPVTVPVSALIFKNVKLCGFWVTQWKKERAQTDREEIVKMIRDLCDLIRRGKLVPPPSTQRPLEDFSRALQDSQTPFLSRKQILIM
Protein: BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate) (Q8BKX1)
Organism: Mus musculus (Mouse)
Function: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity). {ECO:0000250}.
Interaction partners:
- Actin-binding protein WASF2
- Cell division control protein 42 homolog
- Epidermal growth factor receptor kinase substrate 8
- Actin-binding protein WASF1
- Disks large homolog 4
- Vasodilator-stimulated phosphoprotein
- Ras-related C3 botulinum toxin substrate 2
- Ras-related C3 botulinum toxin substrate 3
- Abl interactor 1
- Adhesion G protein-coupled receptor B1
Sequence:
MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTFAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEETLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPNKIPDRAVQLMQQMANSNGSILPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQENVPVMNGVAGPDSEDYNPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLALPPPDYGTSSRAFPTQTAGTFKQRPYSVAVPAFSQGLDDYGARSVSRNPFANVHLKPTVTNDRSAPLLS
Protein: Protein NETWORKED 1C (Q9ZQX8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plant-specific actin binding protein. May be part of a membrane-cytoskeletal adapter complex.
Interaction partners:
- PRA1 family protein
- Kinase-interacting family protein
Sequence:
MEIAAKSNSKRMYSWWWDSHNTPKNSKWLQDNLADMDSNVKQMIKVLEEDADSFARRAEMYYRKRPELMKLVEEFYRAYRALAERYNHATGVIHKAHETIAEAFPNQVPLIFGDESHGGALTNDVDPQTPDMPPPFRARGNPDEFQQDALGFSLSHVHDVKRNIDFSEEPLFVSNGKARKGLNFNDHGDGKGRNGLKDHILSESERASKAEAEVVALKDSLSKMQAEKQASLALFEKNLERLSNLESEVSRAQADSRGINDRAASAEAEIQTLRETLYKLESEKESSFLQYHKCLQKIADLEDGLSVAHKEAGERASKAETETLALKRSLAKAETDKETALIQYRQCLNTISNLEERLRKAEEDARLINERAEKAGVEVENLKQTVSKLIKDKEASELQFQQCLNIIASLKVKLHHAQEETQSLSHEIEDGVAKLKFSEEKCLLLERSNQNLHSELDSLLEKLGNQSQKLTEKQTELVKLWSCVQAEHLHFQEAETAFQTLQQLHSQSQEELNNLAVELQTVSQIMKDMEMRNNELHEELEQAKVENKGLNDLNFTMEKLVQKNLMLEKSISYLNSELESFRRKLKTFEEACQSLSEEKSCLISENQHNVIENTVLIEWLRQLRLEAVGIATEKTDLEGKAKTIGDKLTDAETENLQLKRNLLSIRSEKHHLEDEITNVKDQLHEKEKEFEEIKMEKEKLIQEVFKERKQVELWESQAATFFCDKQISVVHETLIEATTRELAEACKNLESKSASRDADIEKLKRSQTIVLLNESIKSLEDYVFTHRESAGEVSKGADLMDEFLKLEGMCLRIKAIAEAIMEKEKFLMLENTNTYSMLEASLKQIKELKTGGGRSMRKQDGGSGRMRKQSHETEMVMKDIVLDQTSDGSSYEIVSKKGNSELDHLGFVELKPVKTHKTETKALSEESLIVEKVEIFDGFMDPNREVNKRRVLERLDSDLQKLENLQITVEDLKSKVETVEKEKTKVGENEYKTIKGQLEEGEEAIEKLFTVNRKLTTKAESEKDIDRRRRIFEHARRGTEKIGRLQSEIQRIQFLLMKLEGEREHRLRSKISDTKVLLRDYIYGRTRSVSMKKRTKKRSVFCGCVQQPESP
Protein: HL01444p (Nimrod B2) (Q7KTA1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRSSSCQLVTLGVLLAICSLGQGQFKTAGIKTRQPPSGNLQLAGNSSESGWRSYNQSSYGWSTQNQSNYAWNQQNHVEQGSAGFVRAEVFQPVTLPPLYGHYVQPVTPPAHRVQVLDETALFINKTRSAMASGVCYKEVPTASLLRNSRDQFVGNGTTPDMSRIQVCCDGYERNPHIYRRCEPICADDCRNGICTAPNTCVCIPGHVRTAEGKCISTCPLGCGNGVCDERNECKCREGYSLEPETRKYCQPECKPGCSFGRCVAPNKCACLDGYRLAADGSCEPVCDSCENGKCTAPGHCNCNAGYLKLQGRCEPICSIPCKNGRCIGPDICECASGFEWDRKSAECLPKCDLPCLNGVCVGNNQCDCKTGYVRDEHQRNICQPHCPQGCQNGYCSAPNFCICRPGFIKSGIKGRQTCQAV
Protein: Protein RER1B (AtRER1B) (O48671)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein RETICULATA-RELATED 1
- Syntaxin-31
- Protein transport protein SEC24 C
- AT5g48790/K24G6_12)
- Trafficking protein particle complex subunit-like protein
- HVA22-like protein i
- Protein transport protein SEC23 A
- NDR1/HIN1-like protein 1
- Cysteine-rich receptor-like protein kinase 7
- Protein IMPAIRED IN BABA-INDUCED STERILITY 1
Sequence:
MEGSGGDSGSMATPVQKKVHEAWRVYQYYLDKTTPHSTNRWIGTLVFFLIYCLRVYSIHGFYIISYGLGIYLLNLLIGFLSPLVDPELEVSDGATLPTRGSDEFKPFIRRLPEFKFWYSMTKAFCIAFLMTFFSVFDVPVFWPILLCYWVVLFVLTMRRQIAHMIKHKYIPFSIGKQKYSGRKSSANSGGGSRAD
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (EC 2.7.11.31) (Acetyl-CoA carboxylase kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (Tau-protein kinase PRKAA1) (F2X9C1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
ARRLFQQIISAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFFTPQYLNPSVAALLKHMLQVDPMKRATIKEIREDEWFKDELPKYLFPEDPCYSNNMIDDEALKEVCEKFECTEEEILTCLYSRSHHDPLAVAYYLIIDNR
Protein: Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP) (P49445)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the regulation of T and B-lymphocyte development and signal transduction.
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20157115}.
Interaction partners:
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 14
- Dual specificity protein phosphatase
- Tyrosine-protein phosphatase non-receptor type 5
- mitogen-activated protein kinase
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 13
- Mitogen-activated protein kinase 8
- Receptor-type tyrosine-protein phosphatase R
Sequence:
MVQACEGRSRAQLPTLSLGADMTQPPPAKAPAKKHVRLQERRGSSVALMLDVRSLGTVEPICSVNTPREVTLHFLRTAGHPLTRWTLQHQPPSPKQLEEEFLKIPSNFVNPEDLDIPGHASKDRYKTILPNPQSRVCLGRAHSQEDSDYINANYIRGYDGKEKVYIATQGPMPNTVADFWEMVWQEDVSLIVMLTQLREGKEKCVHYWPTEEEAYGPFQIRIQGMKEHPEYTVRHLTIQHQQECRSVKHILFSAWPDHQTPESAGPLLRLVAEVETPETAANSGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAAQLPPETDP
Protein: Anaphase-promoting complex subunit 11 (APC11) (Q20052)
Organism: Caenorhabditis elegans
Function: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9NYG5}.
Interaction partners:
- Abnormal embryogenesis protein 30
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 2
- Cell division cycle protein 16 homolog
- Cell division cycle protein 23 homolog
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 1
- Protein gfi-3
- Suppressor of spindle checkpoint defect 1
Sequence:
MEQQIQMDEQENDESQGNDDQQNMSMSSSELHTMQDDHPGILLKTNTRMSITVKKLHVCGEWKWLQGGEDTCGICRMEFESACNMCKFPGDDCPLVLGICRHAFHRHCIDKWIAAPTNQPRAQCPLCRQDWTIVE
Protein: IP13064p (Spermitin, isoform E) (Q4V503)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLHCQVEGAKAEQRECPVMHSENSAETFSSEESQASDCNQPLDVQSPKLTTNIEESFKVDCKLSLNTLLSPINITDPLLMCSISEFNKEEQTMEPYFIQELDMACAGQEVEQVAEENVFETGPQLKLPENQPINDSITTETNETKLPSTEALNVLNLAEFSEPVMEKSNISIEEVNLTGAEEINEPISDEPNSQLVESAAKLQPKSLGIQIPPLQIEDLISPLVEQPKIATKLGVISFLTGNKLALTPSVRLSFGDRVTTRTNKKSKEIVQQQASKALKALISVFTMQRRLEASQCDNSNNSRSKRFEQLKSSLTFSRVFRQNIFQPTSKIESRQQNTDANSLESGEPNFKSTSAYKEPLPIPYRQDAGEGLTCNGLNVSKDSVFSEVSESDVSETHNKLFAMKKTQEGLSSTRSIGELSNILNNGRVLFSQPVRLFCFNKLKEWKRQGKVPRFHESPYRSPSFSGEGQIEVIEHHGSYYIVLHDKVSGELIIHMRVDEKWRIDYMTKSSYSCRWTNINYANCRDGTLERIACSFREPSHAAEFVARIRNSALQSRLECSS
Protein: Uncharacterized protein (Q386B3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVNQTAGEEARVFVNNQNTRVATVTLPTLTKRSGGRALDGATDNSDSDGSREDMRDLNGYQTLKNAGKTLSSKDVHPRLEGVYHRVMRQLQWRANYGSVGTPPLGIRLGVESDKDSKVPERTFEQEELMNSNMSLTSTLLPEATPSLVKKRPSSQSVGKNLILSSPMKGDEGDEGALLAQQPCPKTLRLIVEEVTNTIVEKLKIAQIGSIKSCLCQVFESRALLDRLLKEIPSYSQFQGDGERLLTPMKLQELYQEFRKQPTVLPNACYVRDPVNGSVLACTGDMCAAANDPEVPPVDEQPVPQQQEQVAEQPKTLMSSQFTLCQQSVSLTGTWVGSEAKKPLQMNFAEAAIPATYGKSSRIPQNVESPSKNKAPDMKLKFAPRPAAIVTSGSIQQDLSSEVSTVGREGGDLTREHSAPTSSSRSHCTSKLDTQYAPLSGGGKPKELSEVAKCHQETRYVSVGVVTDSNSTTTVTCEKYDELVRYVESLHVDIEEKKREIKLLKEELSEEQQYTSRKKKVVQYLRETLYRECSALRSQLTIVQQKQIQYQTALKDQQRSLTGMQASPIYFQSPAGVCGGDRKRNNSFSRGEFWRPPSSGVSRPGAYESSRGLNNSASDLTRRPTPGSAQSHRRHGTHSDENDENASVDDPSTDIGSSYTTRNMNAYDGRGGGLNRSMSMTRDVISIDCTAVQSLLDLVLLAVENDQVLPASASKARNANMEIIGKAMVTDPETSERRARKHFELVQRKMKENYARSRGELLAALNTKEREITKIKNATDKQYLEKFLREQVDELRSSYRRIRRATVENLSELWNSVYLMMDGILNRATVVDASLRDNEKLYTSFTALQDLVSAGTSLIGPMLTTEYGRGYHPWPLKLRNTSEPFRVMLRARYGETQLQPIHEEMSAFNDLYVNAHQYVTRNHVVPQLKRPAVGPTLRQLCALLVLNSATTNEVWQQVSEKYGREKNLQRHIALLNFSLVSLMYRQRVLADRSAAALREAGMDMKLIGLPVQRRVNRIAEELHKVIAERSTVRRQRVDNARDVYRIWKATQINIYEGYATPAMPPRLTLVRCDARGAADLGPFTPHLRGESNAEPHLHMTTDSRRAMHELINREGADDVLGSDGISHASTSAILSPTAAAAETNE
Protein: Histone-lysine N-methyltransferase Suv4-20 (EC 2.1.1.362) (SET domain-containing protein 4) (Suppressor of variegation 4-20 homolog) (Su(var)4-20 homolog) (Q09265)
Organism: Caenorhabditis elegans
Function: Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity). Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway.
Subcellular location: Nucleus {ECO:0000305|PubMed:23028348}. Chromosome {ECO:0000305|PubMed:23028348}.
Interaction partners:
- Histone-lysine N-methyltransferase set-1
- SET domain-containing protein
- Lysine-specific demethylase 9
- JmjC domain-containing protein
- Histone-lysine N-methyltransferase set-2
- Histone-lysine N-methyltransferase
- Histone-lysine N-methyltransferase set-25
- Chromosome condensation protein dpy-27
Sequence:
MQLHEQIANISVTFNDIPRSDHSMTPTELCYFDDFATTLVVDSVLNFTTHKMSKKRRYLYQDEYRTARTVMKTFREQRDWTNAIYGLLTLRSVSHFLSKLPPNKLFEFRDHIVRFLNMFILDSGYTIQECKRYSQEGHQGAKLVSTGVWSRGDKIERLSGVVCLLSSEDEDSILAQEGSDFSVMYSTRKRCSTLWLGPGAYINHDCRPTCEFVSHGSTAHIRVLRDMVPGDEITCFYGSEFFGPNNIDCECCTCEKNMNGAFSYLRGNENAEPIISEKKTKYELRSRS