wanglab/gogpt-training-data huggingface dataset:
Protein: La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) (Q4G0J3)
Organism: Homo sapiens (Human)
Function: RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif. U6 snRNA processing is required for spermatogenesis (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:18483487}.
Interaction partners:
- Protein HEXIM1
- 7SK snRNA methylphosphate capping enzyme
- Protein HEXIM2
- Cyclin-dependent kinase 9
- Cyclin-T1
- Cyclin-T2
- Spliceosome associated factor 3, U4/U6 recycling protein
- Bromodomain-containing protein 4
- Protein phosphatase 1G
- Nucleolar RNA helicase 2
Sequence:
METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD
Protein: Ricin B-like lectin EULS3 (Euonymus lectin S3) (AtEULS3) (Q945P1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lectin which binds carbohydrates in vitro. Interacts through its lectin domain with glycan structures containing one or more Lewis X, Lewis Y or lactosamine motifs. May play a role in abiotic stress responses (Probable). May play a role in abscisic acid-induced stomatal closure. May play a role in disease resistance against Pseudomonas syringae through its involvement in stomatal movement.
Subcellular location: Nucleus {ECO:0000269|PubMed:21945438}. Cytoplasm {ECO:0000269|PubMed:21945438}.
Interaction partners:
- Calcium-dependent protein kinase 3
- Translocon-associated protein subunit beta
- At2g29670/T27A16.23
- Embryo-specific protein ATS3B
- Embryo-specific protein ATS3A
- Abscisic acid receptor PYL9
- Oxysterol-binding protein-related protein 2A
- F14L17.20 protein
- Aldehyde oxidase GLOX
- Glyoxal oxidase-related protein
Sequence:
MEHHHQHHRHHQRDDGEDDRQSFGVPPPHVDAPPQPHGLYQSQPHFDPYAPTPQAPAPYRSETQFEPHAPPPYRSEPYFETPAPPPSFGHVSHVGHQSPNESYPPEHHRYGGYQQPSNSLLESHGDHSGVTHVAHHSSNQPQSSSGVYHKPDENRLPDNLAGLAGRATVKVYSKAEPNYNLTIRDGKVILAPADPSDEAQHWYKDEKYSTKVKDADGHPCFALVNKATGEAMKHSVGATHPVHLIRYVPDKLDESVLWTESKDFGDGYRTIRMVNNTRLNVDAYHGDSKSGGVRDGTTIVLWDWNKGDNQLWKIFPF
Protein: Protein TIFY (Jasmonate ZIM domain-containing protein) (A7XXZ0)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369065}.
Interaction partners:
- Coronatine-insensitive 1
- Transcription factor MYC2
- Protein JAZ7
- Transcription factor MYC1
- Tify domain-containing protein
- Protein TIFY
- Protein TIFY
- Protein TIFY
- Protein TIFY
- Protein TIFY
Sequence:
MGSSENMDSGKVTGQKSQFSQTCNLLSQFLKKKGSVGDLNNLGIYKTTFESTGSQQTATTTTTTMNLLPMIEKSSDSSSSSSSVETNPQKPMNLFPQEFDFSKEQSTKKTESWKPDQPEKAQMTIFYGGQVIVFDDFPADKANEIMKLANKQNPTNNFTYPMIKNQKTADQSGVSFGNKLIQELPKLSMPQPSVADLPIARRNSLTRFLEKRKDRVTSIAPYQISNNKKSKNEDNKAWLGLGAQFVKTEQYF
Protein: G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog) (Q9NYZ3)
Organism: Homo sapiens (Human)
Function: May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.
Subcellular location: Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Interaction partners:
- Serine/threonine-protein kinase PLK1
- Cellular tumor antigen p53
- Holliday junction recognition protein
- 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial
- Baculoviral IAP repeat-containing protein 5
- Cyclin-dependent kinase inhibitor 1
- Aurora kinase B
- Microtubule-associated protein RP/EB family member 1
- Proliferation marker protein Ki-67
- G2/mitotic-specific cyclin-B2
Sequence:
MEGGGGRDEPSACRAGDVNMDDPKKEDILLLADEKFDFDLSLSSSSANEDDEVFFGPFGHKERCIAASLELNNPVPEQPPLPTSESPFAWSPLAGEKFVEVYKEAHLLALHIESSSRNQAAQAAKPEDPRSQGVERFIQESKLKINLFEKEKEMKKSPTSLKRETYYLSDSPLLGPPVGEPRLLASSPALPSSGAQARLTRAPGPPHSAHALPRESCTAHAASQAATQRKPGTKLLLPRAASVRGRSIPGAAEKPKKEIPASPSRTKIPAEKESHRDVLPDKPAPGAVNVPAAGSHLGQGKRAIPVPNKLGLKKTLLKAPGSTSNLARKSSSGPVWSGASSACTSPAVGKAKSSEFASIPANSSRPLSNISKSGRMGPAMLRPALPAGPVGASSWQAKRVDVSELAAEQLTAPPSASPTQPQTPEGGGQWLNSSCAWSESSQLNKTRSIRRRDSCLNSKTKVMPTPTNQFKIPKFSIGDSPDSSTPKLSRAQRPQSCTSVGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCVPARRRSSEPRKNSAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTATEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAASQPLIDLPLIDFCDTPEAHVAVGSESRPLIDLMTNTPDMNKNVAKPSPVVGQLIDLSSPLIQLSPEADKENVDSPLLKF
Protein: Transcriptional activator protein NhaR (Na(+)/H(+) antiporter regulatory protein) (P0A9G2)
Organism: Escherichia coli (strain K12)
Function: Plays a role in the positive regulation of NhaA.
Subcellular location: Cytoplasm.
Interaction partners:
- Na
- Carbon storage regulator
- Poly-beta-1,6-N-acetyl-D-glucosamine export protein
Sequence:
MSMSHINYNHLYYFWHVYKEGSVVGAAEALYLTPQTITGQIRALEERLQGKLFKRKGRGLEPSELGELVYRYADKMFTLSQEMLDIVNYRKESNLLFDVGVADALSKRLVSSVLNAAVVEGEPIHLRCFESTHEMLLEQLSQHKLDMIISDCPIDSTQQEGLFSVRIGECGVSFWCTNPPPEKPFPACLEERRLLIPGRRSMLGRKLLNWFNSQGLNVEILGEFDDAALMKAFGAMHNAIFVAPTLYAYDFYADKTVVEIGRVENVMEEYHAIFAERMIQHPAVQRICNTDYSALFSPAVR
Protein: Large ribosomal subunit protein eL21A (60S ribosomal protein L21-A) (Q02753)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL14B
- Large ribosomal subunit protein eL8B
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL30A
- Small ribosomal subunit protein uS4B
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein uS15
Sequence:
MGKSHGYRSRTRYMFQRDFRKHGAVHLSTYLKVYKVGDIVDIKANGSIQKGMPHKFYQGKTGVVYNVTKSSVGVIINKMVGNRYLEKRLNLRVEHIKHSKCRQEFLERVKANAAKRAEAKAQGVAVQLKRQPAQPRESRIVSTEGNVPQTLAPVPYETFI
Protein: Homeobox-leucine zipper protein (HD-ZIP protein) (Homeodomain transcription factor) (G1AQA5)
Organism: Zea mays subsp. mays (maize)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
GEQKKARQRRRRKPRPAEGGEGADEQARKRRLSDDQARFLELSFRKERKLETPRKVQLAAELGLDAKQVAVWFQNRRARHKSKLMEEEFSKLRAAHDAVVLHNCHLETE
Protein: Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor) (PCaR1) (Q9QY96)
Organism: Mus musculus (Mouse)
Function: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (By similarity). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P41180}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41180}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- G-protein coupled receptor family C group 6 member A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
- Guanine nucleotide-binding protein G
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Sequence:
MAWFGYCLALLALTWHSSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNMTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQQVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGRIWLASEAWASSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCHLQDGAKGPLPVDTFVRSHEEGGNRLLNSSTAFRPLCTGDENINSVETPYMDYEHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEGKILWSGFSREVPFSNCSRDCQAGTRKGIIEGEPTCCFECVECPDGEYSGETDASACDKCPDDFWSNENHTSCIAKEIEFLAWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICIIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKVYIILFKPSRNTIEEVRSSTAAHAFKVAARATLRRPNISRKRSSSLGGSTGSIPSSSISSKSNSEDRFPQPERQKQQQPLALTQQEQQQQPLTLQPQQQQQPQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSMRQNSLEAQKSNDTLNRHQALLPLQCAEADSEMTIQETGLQGPMVGDHQPEIESPDEMSPALVMSTSRSFVISGGGSSVTENILHS
Protein: U6 snRNA-associated Sm-like protein LSm7 (Q9CQQ8)
Organism: Mus musculus (Mouse)
Function: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9UK45}.
Interaction partners:
- U6 snRNA-associated Sm-like protein LSm2
- U6 snRNA-associated Sm-like protein LSm4
- U6 snRNA-associated Sm-like protein LSm6
- U6 snRNA-associated Sm-like protein LSm8
- U6 snRNA-associated Sm-like protein LSm1
- U6 snRNA-associated Sm-like protein LSm5
- U6 snRNA-associated Sm-like protein LSm3
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein F
Sequence:
MADKEKKKKESILDLSKYIDKTIRVKFQGGREASGILKGFDPLLNLVLDGTMEYMRDPDDQYKLTEDTRQLGLVVCRGTSVVLICPQDGMEAIPNPFVQQQDT
Protein: Protein STRICTOSIDINE SYNTHASE-LIKE 11 (AtSSL11) (EC 3.5.99.13) (Strictosidine synthase 12) (AtSS12) (Strictosidine synthase 3) (SS-3) (P92976)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.
Subcellular location: Vacuole {ECO:0000250}.
Interaction partners:
- strictosidine synthase
- Protein STRICTOSIDINE SYNTHASE-LIKE 12
- Phenylacetaldehyde synthase
- 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
- Tropinone reductase homolog At2g29320
- Tropinone reductase homolog At5g06060
- Tropinone reductase homolog At2g29150
- Tropinone reductase homolog At1g07450
- Tropinone reductase homolog At2g29340
- Tropinone reductase homolog At2g29310
Sequence:
MMRSFVSLISLLLLLSFSSSVLSTKKSSFQKLPVPGNRTGPEAFAFDSTGKGFYTGVTGGKILKYLPKKGYVDFAQITNSSKSSLCDGALGTTNVEKCGRPAGIAFNTKTGDLYVADAALGLHVIPRRGGLAKKIADSVGGKPFLFLDGLDVDPTTGVVYFTSFSSTFGPRDVLKAVATKDSTGKFFKYDPSKKVVTVLMEGLSGSAGCAVSSDGSFVLVGQFTKSNIKRYWIKGSKAGTSEDFTNSVSNPDNIKRIGSTGNFWVASVVNSATGPTNPSAVKVSSAGKVLQTIPLKDKFGDTLVSEVNEYKGQLYIGALFGPFAGILKL
Protein: Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) (P62943)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62942}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:1374404, ECO:0000269|PubMed:27468892}; Peripheral membrane protein {ECO:0000269|PubMed:27468892}; Cytoplasmic side {ECO:0000269|PubMed:27468892}.
Interaction partners:
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
Protein: Transcription initiation factor TFIID subunit 9 (TBP-associated factor 9) (Q09869)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- SAGA complex subunit Sgf73
- Transcription initiation factor TFIID subunit 4
- SAGA complex subunit Hfi1
- SAGA complex subunit Ngg1
- SAGA complex subunit Sgf29
- SAGA complex/transcription factor TFIID complex subunit Taf5
- Transcription initiation factor TFIID subunit 11
- TATA-box-binding protein
- SAGA complex/transcription factor TFIID complex subunit Taf10
- SAGA complex/transcription factor TFIID complex subunit Taf12
Sequence:
MSSPGISDESIKGPKDVRLIHLILSSLGVPSYSQTVPLQLLTFAHRYTQQLIQDSQVYAEHSRGQNAPISVEDVRLAVASQINHSFTGPPPKEFLLELAMERNRKPLPQIQPSYGFRLPPEKYCLTQPNWIVSNETQQNQPKEENSSDSRMEEDKLDFSVKSE
Protein: Myosin-11a (Smooth muscle myosin heavy chain) (Q4U0S2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MTKKGLSDDEKFLFTDKDFINSPVAQADWSAKKLVWVPSEKHGFESASIKEEHGDEVLVELMDNGKKITVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVVNPYKMLPIYSEKIIEMYKGKKRHEVPPHIYSITDNAYRNMMQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDMSAGELEKQLLQANPILEAFGNAKTIKNDNSSRFGKFIRINFDVTGFIVGANIETYLLEKSRCIRQAKTERAFHIFYYMVAGTKDKLREELLLENFNNYRFLSAGHVQIPGNQDDEMYDETMEAMEIMGFSVEERADVLKVVSTVLQLGNIEFKKERNQEQATMPDNTAAQKVCHLQGINVTDFTRAILTPRIKAGREVVQKAQTKEQADFAIEALAKAMYERLFRWILLRVNKALDKTKRQGASFLGILDIAGFEIFENNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGILALLDEECWFPKATDVSFVEKLCNTHANHTKFAKPKQLKDKTEFSVQHYAGRVDYNAVAWLTKNMDPLNDNVTALLNNSSNPFVQDLWKDADRVVGLETIAKMSDSLAPSASKTKKGMFRTVGQLYKESLAKLMTTLHNTQPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACCLMIKHLDIDPNLYRIGQSKIFFRTGVLAQLEEERDLKITVIIIAFQSQARGFLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMSLKEEELQKAKESAQKFEIELKDIALKHTQLMDERNQLQEKLQAETELYAEAEEMRVRLASKKQELEEILHEMEARLEEEEDRGAALQMEKKKMHEQIKDLEEHLEEEEDARQKLQLEKVTCDAKIKKLEDDILIMDDQNNKLQKERKILEERIADFSSNLAEEEEKSKNLTKLKNKHESMISELEVRLKKEEKTRQELDKAKRKLEAESNDLQEQIADLQAQIADLKAQLAKKEEELQAALARLEDETGQKNNALKKIRELEGHISDLQEDLESERAARNKAEKTKRDLGEELEALKSELEDTLDTTATQQELRAKREQEVTLLKRAIEDESRVHEAQVQEMRQKHTQALEELTEQLEQSKRVKVNLEKAKQALEKETSELHVELRSLTQGKQDVEHKKKKLEGQLADLQSRFNDSERHKAELGDRVSKITVELESVTNLLNEAEGKNIKLSKDVASLSSQVQDTQELLAEETRQKLQLSTKLRQIEDDRNALQEQLDEEAEAKRNVERHVSTLNIQLSDFKKKLEEMTGNVELLEEGKKRLQRDLEAANTQFEEKAAAYDKLEKTKNRLQQELEDTLMDLDNQRQLVSNLEKKQKKFDQMLAEEKSISSKYADERDRAEAEAREKETKALSLARALEEAQEAREEFERANKALRAEMEDLVSSKDDVGKNVHELEKSKRGLEAQVEEMKTQLEELEDELQAAEDAKLRLEVNMQALKAQFERDLQGRDEQGEEKKRQLVKQVRELETELEDERKQRTALAASKKKLEGDLKDLEGQIETSNKGRDEAIKQLRKLQAQMKDFQRELDDAHAAREEVLSSAKENERKAKTLEAELLQLQEDLAAAERAKKQVEAERDELADELASNASGKSALSDEKRRLEAKIQQLEEELEEEQGNMEMLNDRLRKSAQQVDQLTNELQAERTTSQKNESARQLMERQNKELKAKLQEMENQVKSKFKSSISALEAKVAQLEEQLEQESRDKQNTAKAVRQKDKKLKEMMTQVEDERKQAEQYKDQADKATARVKQLKRQLEESEEESQRITAARRKLQRELDEATETNDAMSREVNSLKSKLRRGNETSSFSSTPRRTGGGGRRGIIDSSDAAEDDADMQSDYNGTKSNE
Protein: Protein TIFY 10A (Jasmonate ZIM domain-containing protein 1) (Q9LMA8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Repressor of jasmonate responses. Jasmonoyl-isoleucine (JA-Ile) specifically promotes COI1-TIFY10A/JAZ1 interaction. Interacts with COI1 and inositol pentakisphosphate to form a high-affinity jasmonates coreceptor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:17499004, ECO:0000269|PubMed:17637677}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C9E3, ECO:0000255|PROSITE-ProRule:PRU00768}. Cell membrane {ECO:0000250|UniProtKB:Q9C9E3}. Note=(Microbial infection) Interacts with Pseudomonas syringae HopZ1a at the plasma membrane and in the nucleus. {ECO:0000250|UniProtKB:Q9C9E3}.
Interaction partners:
- Coronatine-insensitive protein 1
- Transcription factor MYC2
- Transcription factor MYC3
- Protein TIFY 5A
- AFP homolog 2
- Transcription factor MYC4
- Transcription factor MYB24
- Transcription factor ICE1
- Transcription factor MYB21
- SKP1-like protein 1A
Sequence:
MSSSMECSEFVGSRRFTGKKPSFSQTCSRLSQYLKENGSFGDLSLGMACKPDVNGTLGNSRQPTTTMSLFPCEASNMDSMVQDVKPTNLFPRQPSFSSSSSSLPKEDVLKMTQTTRSVKPESQTAPLTIFYAGQVIVFNDFSAEKAKEVINLASKGTANSLAKNQTDIRSNIATIANQVPHPRKTTTQEPIQSSPTPLTELPIARRASLHRFLEKRKDRVTSKAPYQLCDPAKASSNPQTTGNMSWLGLAAEI
Protein: Olfactory receptor (Q8VF35)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
MSMENSSTGTKFILLGMTDNYQLAVLLFGLFFIIYFITVLGNLGLVVLIQVSHRLHTPMYFFLSNLSFLDVCFSSITTPKTLVNLLSQLQEVSFFGCMAQMGLFIVFASAECNILASMAYDRYTAICRPLLYHITMSKVRCLLLVAGCYLGGLLNMVAVTTSITQLSFCQPQVISHFFCDIPPLLALACSDPWVTQVLVVGCGGFTLVTSVMVILVSYLSIFMTIMGIPSVSGKQKAFSTCASHLTAVALYYGTTMYTYLQPSRHGSQAGNRMISVFYTMLIPMLNPLIYSLRNQEVKVALQKILRHSQ
Protein: Protein Wnt-4 (P56705)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary. Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Frizzled-3
- Frizzled-6
- Frizzled-2
- Wnt inhibitory factor 1
- Frizzled-4
- Frizzled-5
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-8
- Frizzled-9
- Secreted frizzled-related protein 1
Sequence:
MSPRSCLRSLRLLVFAVFSAAASNWLYLAKLSSVGSISEEETCEKLKGLIQRQVQMCKRNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAQVELAERCSCKFHWCCFVKCRQCQRLVELHTCR
Protein: Protein SCO2 homolog, mitochondrial (O43819)
Organism: Homo sapiens (Human)
Function: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:15229189}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase copper chaperone
- Heme A synthase COX15
- Surfeit locus protein 1
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 3
- Cellular tumor antigen p53
- Protoheme IX farnesyltransferase, mitochondrial
- Cytochrome c oxidase assembly protein COX11
- Cytochrome c oxidase assembly factor 6 homolog
Sequence:
MLLLTRSPTAWHRLSQLKPRVLPGTLGGQALHLRSWLLSRQGPAETGGQGQPQGPGLRTRLLITGLFGAGLGGAWLALRAEKERLQQQKRTEALRQAAVGQGDFHLLDHRGRARCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPERDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSVLS
Protein: A-type ATP synthase subunit A (EC 7.1.2.2) (A8AC29)
Organism: Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00309}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00309}.
Interaction partners:
- A-type ATP synthase subunit E
- A-type ATP synthase subunit B
- Uncharacterized protein
- H+-transporting two-sector ATPase, C subunit
- A-type ATP synthase subunit I
- Vacuolar H+-transporting two-sector ATPase, F subunit
- A-type ATP synthase subunit D
- Inorganic pyrophosphatase
- Uncharacterized protein
Sequence:
MAVKGKVLRVRGPVVIAEDMQGVQMYEVVEVGKDGLVGEVTRITGDKAVIQVYEDTTGITPGEPVVGTGSPFSVELGPGLLSHIFDGILRPLESIHEVAKSPFIKRGIKVPSLDRSKKWEWRPNPELKPGDKVSGDDILGTVPETPLIEHKVMVPPNVVPVDKAATLKWLAPAGEYTIEDTIAVVEYEGKEIELKMYHRWPIRRPRPVKEKFEPVTPLITGVRVLDTLFPMAKGGTGAIPGPFGSGKTVTLRTLAAWSDAKVVIYVGCGERGNEMTDVLVNFPHYKDPWSGRPLMERTILVANTSNMPVAAREASIYVGVTLAEYYRDMGYDSLLIADSTSRWAEALRDIAGRMEEMPAEEGFPPYLASRLAEYYERAGRARIPGRPERVGSVTIASAVSPPGGDFSEPVTSHTRRFVRVFWALDASLAYARHYPAINWLVSYSLYVDTVAKWWHENISPKWKEYRDEMMSILLKEDELKEIVRLVGPESLSEPDKLIIETARIIKEAFLQQNAFDPIDAFCSPKKQFLMMKIIIDFYRKAKELVNAGVPVATIREAVKEEVAELIRSRFTVRNEELEKLEDLYARFMEKLSSLSP