wanglab/gogpt-training-data huggingface dataset:
Protein: Protein dj-1beta (Q9VA37)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor. Does not play a role in methylglyoxal detoxification. Plays a role in mitochondrial function together with Pink1. In motor neurons regulates structural synaptic plasticity of locomotor behavior as part of the PTEN-phosphatidylinositol 3-kinase pathway in response to oxygen species (ROS) levels.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16203113}. Cytoplasm {ECO:0000269|PubMed:16203113}. Nucleus {ECO:0000269|PubMed:16203113}.
Interaction partners:
- Serine/threonine-protein kinase Pink1, mitochondrial
- E3 ubiquitin-protein ligase parkin
- non-specific serine/threonine protein kinase
- Delta-1-pyrroline-5-carboxylate synthase
Sequence:
MSKSALVILAPGAEEMEFIIAADVLRRAGIKVTVAGLNGGEAVKCSRDVQILPDTSLAQVASDKFDVVVLPGGLGGSNAMGESSLVGDLLRSQESGGGLIAAICAAPTVLAKHGVASGKSLTSYPSMKPQLVNNYSYVDDKTVVKDGNLITSRGPGTAYEFALKIAEELAGKEKVQEVAKGLLVAYN
Protein: Probable RNA-binding protein 46 (Cancer/testis antigen 68) (CT68) (RNA-binding motif protein 46) (Q8TBY0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P86049}.
Interaction partners:
Sequence:
MNEENIDGTNGCSKVRTGIQNEAALLALMEKTGYNMVQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRGYAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQVDWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFNKFKPGAVERVKKLRDYAFVHFFNREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLIVFANKEESHPKTLGKLPTLPARLNGQHSPSPPEVERCTYPFYPGTKLTPISMYSLKSNHFNSAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIVIPAIANGSQSYFMPDKLCTTLEDAKELAAQFTLLHLDYNFHRSSINSLSPVSATLSSGTPSVLPYTSRPYSYPGYPLSPTISLANGSHVGQRLCISNQASFF
Protein: Tyrosine-protein kinase Abl (EC 2.7.10.2) (D-ash) (Protein abelson) (P00522)
Organism: Drosophila melanogaster (Fruit fly)
Function: Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways.
Subcellular location: Cytoplasm.
Interaction partners:
- Abelson interacting protein, isoform D
- Roundabout 1, isoform A
- Adapter molecule Crk
- Serine/threonine-protein kinase ATM
- Trio, isoform A
- Adenylyl cyclase-associated protein
- Protein enabled
- Protein slit
- Cytoplasmic FMR1-interacting protein
- Roundabout 2, isoform B
Sequence:
MGAQQGKDRGAHSGGGGSGAPVSCIGLSSSPVASVSPHCISSSSGVSSAPLGGGSTLRGSRIKSSSSGVASGSGSGGGGGGSGSGLSQRSGGHKDARCNPTVGLNIFTEHNEALLQSRPLPHIPAGSTAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFIDDLSTNGLARDINSLTQRYDSETDPAADPDTDATGDSLEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVMGNRGLETRQSKRSQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAPALPATAPSLPPANGHATPPAARLNPKASPIPPQQMIRSNSSGGVTMQNNAAASLNKLQRHRTTTEGTMMTFSSFRAGGSSSSPKRSASGVASGVQPALANLEFPPPPLDLPPPPEEFEGGPPPPPPAPESAVQAIQQHLHAQLPNNGNISNGNGTNNNDSSHNDVSNIAPSVEEASSRFGVSLRKREPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAPASHLANGSGIAVVDPVSLLVTELAESMNLPKPPPQQQQKLTNGNSTGSGFKAQLKKVEPKKMSAPMPKAEPANTIIDFKAHLRRVDKEKEPATPAPAPATVAVANNANCNTTGTLNRKEDGSKKFSQAMQKTEIKIDVTNSNVEADAGAAGEGDLGKRRSTGSINSLKKLWEQQPPAPDYATSTILQQQPSVVNGGGTPNAQLSPKYGMKSGAINTVGTLPAKLGNKQPPAAPPPPPPNCTTSNSSTTSISTSSRDCTSRQQASSTIKTSHSTQLFTDDEEQSHTEGLGSGGQGSADMTQSLYEQKPQIQQKPAVPHKPTKLTIYATPIAKLTEPASSASSTQISRESILELVGLLEGSLKHPVNAIAGSQWLQLSDKLNILHNSCVIFAENGAMPPHSKFQFRELVTRVEAQSQHLRSAGSKNVQDNERLVAEVGQSLRQISNALNR
Protein: Probable transcription factor At1g55950 (Storekeeper-like protein At1g55950) (Q9LG15)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKRITKLLASHSLKSLMAKKNKRSQQKNKCLKPEKDPSTVKRLLEDPPRKKRYLQPLENPPTESYGDDEKMETEEEGEKYLGKNLPASAFIIVAAERHDSDSYSETELEKKICGSVVVAKMNDDKMVSTDTKKKYFQRILSDDDKIVLLQGMVDFQNDKGTISYDDMTGFIDTVKNIISFQANSRQFTTKIRRLKDKFVQKRNKGVDENSLANVEIYEI
Protein: Chromo domain-containing protein 2 (O42934)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Chromatin remodeling factor mit1
- Histone deacetylase clr3
- Cryptic loci regulator protein 1
- Cryptic loci regulator 2
- Histone-lysine N-methyltransferase, H3 lysine-9 specific
Sequence:
MVKSADLDLMNSIISESDENFSPPPFTVEEAENSINNKSSTASLESPQNGSWHPSLYGLSVPEKTHIQNSLDLYSHGNSGSQKTHNVSFSCEIRKVKSSKLSPISNMEDSEDKKEEDESSSYKNEFKSSSSASVSSNFEKTSGSDDHNSQSPVPLNEGFEYIASSGSEDKNSDEEFAVEMILDSRMKKDGSGFQYYLKWEGYDDPSDNTWNDEEDCAGCLELIDAYWESRGGKPDLSSLIRLTRSRARSSNEASYVEKDESSNSDDSISYKRRRSRNAANRITDYVDSDLSESSMKEKQSKIEKYMKSDKSSKNFKPPFQKKSWEDLVDCVKTVQQLDNGKLIAKIKWKNGYVSTHDNIIIHQKCPLKIIEYYEAHIKFT
Protein: At2g32090/F22D22.16 (Expressed protein) (Lactoylglutathione lyase / glyoxalase I family protein) (Q9SKZ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g57040
- Gb|AAF24581.1
- Triacylglycerol lipase-like protein
- Alpha/beta-Hydrolases superfamily protein
- Probable purple acid phosphatase 20
- ATP-dependent RNA helicase
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- 4-hydroxyphenylpyruvate dioxygenase
- Flavin-containing monooxygenase FMO GS-OX4
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Sequence:
MASLGHIARESSDITRLAQFYKEVFGFEEIESPDFGDLQVVWLNLPGAFAMHIIQRNPSTNLPEGPYSATSAVKDPSHLPMGHHICFSVPNFDSFLHSLKEKGIETFQKSLPDGKVKQVFFFDPDGNGLEVASRS
Protein: Neuregulin 1 (Q6PK61)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPQLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE
Protein: RalA-binding protein 1 (RalBP1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) (Q62172)
Organism: Mus musculus (Mouse)
Function: Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15311}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15311}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q62796}. Nucleus {ECO:0000250|UniProtKB:Q15311}. Mitochondrion {ECO:0000250|UniProtKB:Q15311}. Note=Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis (By similarity). Targeted to the plasma membrane through its interaction with RALB, directed by FGF signaling. Docking on the membrane is required to transduce the Ral signal (By similarity). Recruited by RALA to the mitochondrion during mitosis where it regulates mitochondrial fission. Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells. The region involved in membrane association could form transmembrane domains and expose a part of the protein extracellularly (By similarity). {ECO:0000250|UniProtKB:Q15311, ECO:0000250|UniProtKB:Q62796, ECO:0000250|UniProtKB:Q9PT60}.
Interaction partners:
- Ras-related protein Ral-A
- Ras-related protein Ral-B
- GTPase HRas
- GTPase KRas
- Ras-related protein R-Ras
- GTPase NRas
- Cell division control protein 42 homolog
- RalBP1-associated Eps domain-containing protein 1
- RalBP1-associated Eps domain-containing protein 2
- ADP-ribosylation factor 6
Sequence:
MTECFLPPSSSPSEHRRAEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDVLHEPPDTVSDDDKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKVKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQMDAPSVKPIFGVPLVDAVERTMMYDGVRLPAVFRECVDYMEKHGMKCEGVYRVSGIKSKVDELKAAYDREESPNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGKTTEMEKVQEFQRLLRELPECNHLLLSWLIVHLDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVVLKQVTRPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIDRLRAEIAEIQSRQQHGRSETEEYSSDSESESEDEEELQLILEDLQRQNEELEIKNNHLNQAVHEEREAIIELRVQLRLLQMQRAKSEQQPQEEEEPERRGGIGPPPCDGVLEVRVAKEQAKASPSKDRKETPI
Protein: POU domain, class 3, transcription factor 1 (Octamer-binding protein 6) (Oct-6) (Octamer-binding transcription factor 6) (OTF-6) (POU domain transcription factor SCIP) (Q03052)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P21952}.
Interaction partners:
- Transcription factor SOX-10
- POU domain, class 3, transcription factor 2
- E3 SUMO-protein ligase EGR2
- Adhesion G-protein coupled receptor G6
- Coiled-coil domain-containing protein 6
Sequence:
MATTAQYLPRGPGGGAGGTGPLMHPDAAAAAAAAAAAERLHAGAAYREVQKLMHHEWLGAGAGHPVGLAHPQWLPTGGGGGGDWAGGPHLEHGKAGGGGTGRADDGGGGGGFHARLVHQGAAHAGAAWAQGSTAHHLGPAMSPSPGASGGHQPQPLGLYAQAAYPGGGGGGLAGMLAAGGGGAGPGLHHALHEDGHEAQLEPSPPPHLGAHGHAHGHAHAGGLHAAAAHLHPGAGGGGSSVGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGGGASPPSAPPPPPPAALHHHHHHTLPGSVQ
Protein: Basic blue protein (Plantacyanin) (Q8LG89)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Forms a concentration gradient along the pollen tube growth path, with a lower level in the stigma papilla cell wall and a higher level in the transmitting tract extracellular matix of the style.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15908590}.
Interaction partners:
- Laccase-3
- Superoxide dismutase 1
- Laccase-7
- Laccase-12
- Laccase-13
- Laccase-5
- Laccase-17
- Laccase-4
- Squamosa promoter-binding-like protein 7
- Laccase-1
Sequence:
MAKGRGSASWSARAIVTLMAVSVLLLQADYVQAATYTVGDSGIWTFNAVGWPKGKHFRAGDVLVFNYNPRMHNVVKVDSGSYNNCKTPTGAKPYTSGKDRITLSKGQNFFICNFPNHCESDMKIAVTAV
Protein: Histone H4 (A0A0B4KFZ9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Protein: SAP domain-containing protein (P91156)
Organism: Caenorhabditis elegans
Interaction partners:
- Probable histone deacetylase complex subunit SAP18
- RRM domain-containing protein
- Pinin/SDK/MemA protein domain-containing protein
- Protein mago nashi homolog
- SRRM2 protein homolog rsr-2
- RNA helicase
- Beta-lactamase domain-containing protein 2
- DUF4440 domain-containing protein
- Nuclear cap-binding protein subunit 1
- Peptidyl-prolyl cis-trans isomerase E
Sequence:
MADEDILVDGRPLSSLKVTELKEELENRQLSTKGVKAVLQERLREALAAQGDDPVVDEQNPIVAGYLARQSAALAEARKRTESEASGTTTPQSEVSPSKQSEASPRKGRTPRKEKKDVEPEAEPEPEADIAPEPEKVAIVEKPEPKPEPITETEASPSKASEKDAAVEVSVEKVDAETAQESDSPQEAEKEKTEPQVELENGGQEEDEPDRDESIEKQPEKEDDGDELDYGDDEEKEQKDDESMDAEDAKEEKVVQIEKEKKEDKDDGVKKEEKVREVSRRRVSSPSSRHPVSNVVHIRGLTRPFTEGQLRAEIQKNCGEIVDLWMDKVKSHCFVKLNSDADAGNVISAMNNVVWPDGNPKRLSIVYDTEDNLIKHRNGLEATIAEPAKIGGGRADRLSTTSQSSILGGKTNFQITMQNVLRDNDKLDSERKRERGSIQSRLTRIENKDQVKDEKKDEKKEDRKRKRSETPPFSRGAGFMDEKKARNEERERRREGPRSEERRKVVVEEEEAPKKSLDQLFKKTVALPPIYYLPLTEEQIAAKEAEKSAKGKERAETTSDRDRPHRVDRNDRGDRPRHRD
Protein: Calponin-homology (CH) domain-containing protein (Q8BYE8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MNGSLGTKLLLCVSAGSANDKIEDINGCPKNRSQMIENIDACLNFLAAKGINTQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQQQQQPEKQPLSSSPLPPAGSQVAGAPSQCQAGTPQHQGLATPQAPCQLLQPVSHQQGKTQVEMQSRLPGPTARVAAAGSEAKTRGGSAAANNRRSQSFNNYDKSKPVTSPPPPAPPSNHEKEPLASSASSHPGMSENVPAPLENSPSVPVNCSSSAIPQPSMTSKPWRSKSLSVKHTATSAMLSVKPAGPEAPRPTPEAMKPAPNNQKSMLEKLKLFNSKGGSKAGEGSASRDTSCERLEILPSFEETEELEATANRALSTVGPASSSPKIALKGIAQRTFSRALTNKKSSPKGNEKEKEKQQREKEKEKEKEKGKDLTKRVSVTDRPDLKEETKADLSGVAVTEMPKKSSKIASFIPKGGKLNSTKKEATAPSHSGIPKPGMKNVSAKSPSAPIPPKEGERSRGKLSSGLPPQKAQLDSRHSSSSSSLASSEGKGPGGTSLNPSISSQTVSGSVGTTQTTGSNTVSVQLPQPQQQYNHPNTATVAPFLYR
Protein: Major facilitator superfamily (MFS) profile domain-containing protein (Q59WF2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSDCTSSNSVSVEEFNPDPVNELEKKESNVTVTTVSQLPEPNYENISVIREILFMFFMCMSQLLTQAAVSQTMNTQLKIADTYSIQDDPGEMSWFAASFSMTAGTFILVSGRLGDMYGYKLLYIIGYLWFGVFSLLCGFAGLTKSNVFFTTMRGLQGIGPALMMPNSQALIASFYPESLKKNVCLALFGAIAPSGFVVGALFSGLLADLAKWQWTFWLCGIVSIGLAALAFFIIPKKIGLKSSGKFDFWGSLFGVSGLVLINFAFNQGPNIGWHVPYVYVLLIVGFLCIVAFHFVEERVEDPLVPKEALQGDTGFILGCIAAGWSCFGVWLFYTLRWSLVVDNDNAVMSGVKMIPCGPMGVVAAIGGAILLMKVPSAVVMFLAMMAFFIGIVIMGTRPVGQIYWAQKFVSLLIQPIGMDMSFPAACILLSSSLPRHQQGIAGSLVSTFVNYSISIGLGFAGTVEYYTTKNKEPNLSTSIFGMRNAFRMGMGLAGVGVVLSSIFMLLQIINRRKSTRSQDV
Protein: Cathelicidin-B1 (CATH-B1) (Q5F378)
Organism: Gallus gallus (Chicken)
Function: Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). May play a role in the innate immune response.
Subcellular location: Secreted {ECO:0000269|PubMed:17827276}.
Interaction partners:
- Cathelicidin-1
- Cathelicidin-3
- Gallinacin-9
- Gallinacin-14
- Gallinacin-1
- Gallinacin-3
- Gallinacin-8
- Gallinacin-2
- Gallinacin-10
- Gallinacin-4
Sequence:
MGRMWASEVLLLLLLGSSRAVTPGLDVSTAPGLDGSIPPGLDGSVSPGLDGSVSPGLDGSASPGLDGSVSPGLDGSASPGLDGSTPAGRDGTITPKLEGTITPKQDGSISPSWPWRWPITYLDAILAAVRLLNQKISGPCILRLREAQPRPGWVGTLQRRREVSFLVEDGPCPPGVDCRSCEPGALQHCVGTVSIEQQPTAELRCRPLRPQPIRNWWIRIWEWLNGIRKRLRQRSPFYVRGHLNVTSTPQP
Protein: O-antigen polymerase (O-Ag polymerase) (EC 2.4.99.27) (B-band O-antigen polymerase) (G3XCW3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:20824106, ECO:0000269|PubMed:21498511, ECO:0000269|PubMed:24309320}; Multi-pass membrane protein {ECO:0000269|PubMed:20824106}.
Interaction partners:
- O-antigen translocase
- Glycosyltransferase WbpL
- UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase
- LPS biosynthesis protein WbpG
- Imidazole glycerol phosphate synthase subunit HisH 2
- Putative imidazole glycerol phosphate synthase subunit hisF2
- Probable acetyltransferase
- UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase
- Probable glycosyl transferase WbpJ
- O-antigen chain length regulator
Sequence:
MYILARVDRSILLNTVLLFAFFSATVWVNNNYIYHLYDYMGSAKKTVDFGLYPYLMVLALICALLCGGAIRRPGDLLVTLLVVILVPHSLVLNGANQYSPDAQPWAGVPLAIAFGILIIGIVNKIRFHPLGALQRENQGRRMLVLLSVLNIVVLVFIFFKSAGYFSFDFAGQYARRALAREVFAAGSANGYLSSIGTQAFFPVLFAWGVYRRQWFYLVLGIVNALVLWGAFGQKYPFVVLFLIYGLMVYFRRFGQVRVSWVVCALLMLLLLGALEHEVFGYSFLNDYFLRRAFIVPSTLLGAVDQFVSQFGSNYYRDTLLGALLGQGRTEPLSFRLGTEIFNNPDMNANVNFFAIAYMQLGYVGVMAESMLVGGSVVLMNFLFSRYGAFMAIPVALLFTTKILEQSLLTVMLGSGVFLMLLFLALISFPLKMSLGKTL
Protein: Mediator of RNA polymerase II transcription subunit 21 (Q387I6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSGPVVEAEAALMHCVGAMYNALLETVDDAHPRFTADVAGKNSSIELVDTEVYQLEREHNAERQRVGRIADELERHFAALEGAIRALPDDPVASLDRDIELLNTEALSLAQAMIETYDEADALAELLQSEVETRKVPAI
Protein: L-lactate dehydrogenase (EC 1.1.1.27) (W5ULQ0)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- malate synthase
- Citrate synthase
- Isocitrate dehydrogenase
- Succinate--CoA ligase subunit alpha
- Fumarate hydratase, mitochondrial
- Isocitrate dehydrogenase
Sequence:
MASTKEKLIAHVSTEQPVGCTNKVTVVGVGMVGMAAAISILLKELTDELALVDVMEDKLKGEAMDLQHGSLFLKTHKIVADKDYSVTANSKVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCIMLVVSNPVDILTYVAWKLSGLPRNRVIGSGTNLDSARFRFLMGEKLGLHASSCHGWVIGEHGDSSVPVWSGVNVAGVSLQGLNPDMGTDKDKDEWKNVHKMVVDSAYEVIKLKGYTSWAIGMSVADLCESILKNLHKCHPVSTLVKGMHGVNDEVFLSVPCVLGSSGLTDVVKMTLKPEEEKQLVKSAETLWGVQKELTL
Protein: Telomerase-associated protein of 75 kDa (p75) (A0PGB2)
Organism: Tetrahymena thermophila (strain SB210)
Function: Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis (Probable). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (Probable). The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis (Probable).
Subcellular location: Chromosome, telomere {ECO:0000305}.
Interaction partners:
Sequence:
MEIEEDLNLKILEDVKKLYLQSFDYIKNGISSSLPSDKKFLADDDIDLSRITFLYKFISVNPTLLLINEKTQAKRRIFQGEYLYGKKKIQFNIIAKNLEIERELIQFFKKPYQCYIMHNVQVFQMLNKNKNNNVVEFMDSEDLQSSVDCQLYYLIDESSHVLEDDSMDFISTLTRLSDSFNSNEFVFETNYSIQISQMPKPLNTTHFKLLQPKVVNSFEGVILQVQEGKNILQIEELIDQVYLNSRRDRFYILKVANGKNYMDFIEVYLVYDNEDQEAKQQLQFYLKPFQRILIFQSLKHFTKNLKLFMISFFYSSGVQPNNSNVKNFLVSHKGVEFFSRFDIQKNELLCKDLIKSYNKLPLSNISKLLEDEGVMIRSNMKFQVRVKKVKYFKIRLNCLNCKQEWTVGLKNCINCKGQQSYISYNIQVLVQDQHFLEQQAYIYLYDDLAAQFFNITESEKKELHLHLTKNETFIQLYYSFNKDYPLSIIKFKDKIFNKDITNCIVAYPFADIDNKIFNSQQQIIQDENLRIESEKFIQNFTEDNNLQESKLYYEKFKSKNKQQIFVNGTYISTNYSQGQKICLKPIPCLKVMYVFPQEDIKLSALKIIEEINQLKIQIDQLN
Protein: Transcriptional regulator (Q87L53)
Organism: Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Interaction partners:
Sequence:
MSLPHVILTVLSTRDATGYDITKEFSASIGYFWKASHQQVYRELNKMAEKELVTCVLEPQEGKPDRKVYSITDAGRSALGEWFDQPTAHPTVRDEFSAKLMACAVQPSTPFRDQLAELVEESRKLVSHYKEIEAAYYATPSTLDKQARLERLTLRRNLLLRETWITWAEEVLTELEVIG
Protein: Anthracycline biosynthesis protein DnrV (Q9ZAU2)
Organism: Streptomyces peucetius
Function: Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In vivo, it acts jointly with DoxA in the conversion of 13-deoxycarminomycin and 13-deoxydaunorubicin to yield carminomycin and daunorubicin, respectively. In vitro, it also acts jointly with DoxA in the C-14 hydroxylation of daunorubicin to form doxorubicin, although this strain is not a doxorubicin producer.
Interaction partners:
Sequence:
MTRFAPGAPAWFDLGSPDVAASADFYTGLFGWTATVVSDPGAGGYTTFSSDGKLVAAVARHQIDTPYHRPYGPGNDQHGMPAIWTVYFATDDADALTKRVETAGGEVIMTPMDVLGLGRMAVFADPAGAAFAVWRKGVMEGAEVTGVPGSVGWVELVTDGIGAARDFYPATLGLAPADTGLKGVTDPVWHIGDTPVAGTQELGVTGAVRPHWAVLFAVHDCDATVRRAVELGGSVENEPADTPRGRRADLLDPHGAGFSVVELREGYPAAAGGAS
Protein: NADH dehydrogenase subunit 5 (Q7GIL5)
Organism: Oryza sativa (Rice)
Interaction partners:
Sequence:
PLSNFWANSPFVLPKNEILAESEFAAPTITKLIPILFSTSGASLAYNVNLVADQFQRAFQTSTFCNRLYSFFNKRWFFDQVLNDFLVRSFLRFGYSVSFEALDKGAIEILGPYGISYTFRRLAERISQLQSG
Protein: Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13) (Q64464)
Organism: Mus musculus (Mouse)
Function: Can activate aflatoxin B1 to a genotoxic product.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 1A2
- Cytochrome P450 2E1
- Cytochrome P450 1A1
- Cytochrome P450 26A1
- Cytochrome P450 26B1
- Aromatase
- NADPH--cytochrome P450 reductase
- Sulfotransferase 1E1
- Cytochrome P450 26C1
- Polyunsaturated fatty acid lipoxygenase ALOX15
Sequence:
MDLIPNFSMETWMLLATSLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYQKGFWECDIQCHKKYGKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFGPVGILKKAISISENEEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATSFGVNIDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPVFDALNVSLFPRDVISFFTTSVERMKENRMKEKEKQRVDFLQLMINSQNYKTKESHKALSDVEIVAQSVIFIFAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAALPNKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGLLQPENPLLLKVVSRDETVSDE
Protein: Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (EC 1.14.16.4) (Biogenic amine synthesis protein 2) (Phe-4-monooxygenase) (Tryptophan 5-monooxygenase) (P90925)
Organism: Caenorhabditis elegans
Function: Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Catalyzes the hydroxylation of tryptophan to 5-hydroxy-L-tryptophan. Plays a role in the biosynthesis of a melanin-like cuticle pigment.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10928216}.
Interaction partners:
- Putative pterin-4-alpha-carbinolamine dehydratase
- Dihydropteridine reductase
- Tyrosine aminotransferase
- Aromatic-L-amino-acid decarboxylase
- Aspartate aminotransferase, cytoplasmic
- Aromatic-L-amino-acid decarboxylase
- Aspartate aminotransferase
- Aspartate aminotransferase
- Tyrosine 3-monooxygenase
- Tyrosine decarboxylase
Sequence:
MPPAGQDDLDFLKYAMESYVADVNADIGKTTIVFTLREKAGALAETLKLFQAHDVNLSHIESRPSKTHEGCYEVLVEFAEAEDHRKIEGVIEHFQQKAEKKVLVQDWNTKNKQNKDSVPWFPQKINDIDQFANRILSYGAELDADHPGFKDMTYRERRKFFADIAFNFKHGDKIPTITYTDEEIATWRTVYNELTVMYPKNACQEFNYIFPLLQQNCGFGPDRIPQLQDVSDFLKDCTGYTIRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSAPKYTPEPDICHELLGHVPLFADVEFAQFSQEIGLASLGAPDDVIEKLATLYWFTIEFGICQQDGEKKAYGAGLLSSFGELQYALSDKPEVVDFDPAVCCVTKYPITEYQPKYFLAESFASAKNKLKSWAATINRPFQIRYNAYTQRVEILDKVAALQRLARDIRSDISTLEEALGKVNNLKMK