wanglab/gogpt-training-data huggingface dataset:
Protein: WRKY transcription factor 42 (WRKY DNA-binding protein 42) (Q9XEC3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223}.
Interaction partners:
- Phosphate transporter PHO1
- Inorganic phosphate transporter 1-1
- WRKY transcription factor 6
- Transcription factor MYB62
- Protein PHOSPHATE STARVATION RESPONSE 1
- Probable inorganic phosphate transporter 1-5
Sequence:
MFRFPVSLGGGPRENLKPSDEQHQRAVVNEVDFFRSAEKRDRVSREEQNIIADETHRVHVKRENSRVDDHDDRSTDHINIGLNLLTANTGSDESMVDDGLSVDMEEKRTKCENAQLREELKKASEDNQRLKQMLSQTTNNFNSLQMQLVAVMRQQEDHHHLATTENNDNVKNRHEVPEMVPRQFIDLGPHSDEVSSEERTTVRSGSPPSLLEKSSSRQNGKRVLVREESPETESNGWRNPNKVPKHHASSSICGGNGSENASSKVIEQAAAEATMRKARVSVRARSEAPMLSDGCQWRKYGQKMAKGNPCPRAYYRCTMAVGCPVRKQVQRCAEDRTILITTYEGNHNHPLPPAAMNMASTTTAAASMLLSGSTMSNQDGLMNPTNLLARTILPCSSSMATISASAPFPTITLDLTESPNGNNPTNNPLMQFSQRSGLVELNQSVLPHMMGQALYYNQQSKFSGLHMPSQPLNAGESVSAATAAIASNPNFAAALAAAITSIINGSNNQQNGNNNNSNVTTSNVDNRQ
Protein: Collectin-12 (A8C7X1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
GDKGPQGGAGQPGQKGEKGDTGGPGVQGLRGEKGFPGPPGIQGFKGQPGSRGNPGSKGSRGSGGRAGPPGANGEPGTAGLPGRDGQAGPQGPQGPSGDRGQVGPAGAQGPRGPVGPIGAPGPPGLPGLTARSAAAAAVPLVPFSMQSEAPAPTVSAPGCPQEWVGFRDKCYHFSKELHNFDDAKKSCDAQTASMVIINDNDEQKWLQKQTSGKGYFWMGLTDREEENAWRWLDGTEPAFSQWKPGQPDNWSHGHERGEDCAGLIHEGLWNDFFCEDLISYICEKAIEYPKNSRIIAPAVEGEETEEAWLSQRRYDEHH
Protein: ER-retained PMA1-suppressing protein 1 (EC 5.3.4.1) (P40557)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a membrane-bound chaperone in endoplasmic reticulum quality control. Probably facilitates presentation of substrate to membrane-bound components of the degradation machinery.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10545109, ECO:0000269|PubMed:12881414}; Single-pass membrane protein {ECO:0000269|PubMed:10545109, ECO:0000269|PubMed:12881414}.
Interaction partners:
- Endoplasmic oxidoreductin-1
- Endoplasmic reticulum chaperone BiP
- Protein disulfide-isomerase EUG1
- Protein disulfide isomerase MPD2
- Protein disulfide-isomerase MPD1
- Tryptophan synthase
- Protein disulfide-isomerase
- Heat shock protein 70 homolog LHS1
- Calnexin homolog
- Protein transport protein SEC61
Sequence:
MKMNLKRLVVTFFSCITFLLKFTIAAAEPPEGFPEPLNPTNFKEELSKGLHIIDFYSPYCPHCKHLAPVWMETWEEFKEESKTLNITFSQVNCIESADLCGDENIEYFPEIRLYNPSGYIKSFTETPRTKESLIAFARRESMDPNNLDTDLDSAKSESQYLEGFDFLELIAGKATRPHLVSFWPTKDMKNSDDSLEFKNCDKCHEFQRTWKIISRQLAVDDINTGHVNCESNPTICEELGFGDLVKITNHRADREPKVALVLPNKTSNNLFDYPNGYSAKSDGYVDFARRTFTNSKFPNITEGELEKKANRDIDFLQERGRVTNNDIHLVFSYDPETVVIEDFDILEYLIEPLSKIPNIYLHQIDKNLINLSRNLFGRMYEKINYDASQTQKVFNKEYFTMNTVTQLPTFFMFKDGDPISYVFPGYSTTEMRNIDAIMDWVKKYSNPLVTEVDSSNLKKLISFQTKSYSDLAIQLISSTDHKHIKGSNKLIKNLLLASWEYEHIRMENNFEEINERRARKADGIKKIKEKKAPANKIVDKMREEIPHMDQKKLLLGYLDISKEKNFFRKYGITGEYKIGDVIIIDKSNNYYYNKDNFGNSLTSNNPQLLREAFVSLNIPSKALYSSKLKGRLINSPFHNVLSFLDIIHGNGMPGYLIVIVLFIAILKGPSIYRRYKVRKHYRAKRNAVGILGNMEKKKNQD
Protein: Beta-crystallin B3 (Beta-B3 crystallin) [Cleaved into: Beta-crystallin B3, N-terminally processed] (P02524)
Organism: Rattus norvegicus (Rat)
Function: Crystallins are the dominant structural components of the vertebrate eye lens.
Interaction partners:
- Alpha-crystallin A chain
- Filensin
- Alpha-crystallin B chain
- Tuberin
- Phakinin
- Hamartin
- Lens fiber membrane intrinsic protein
- Gamma-crystallin A.
Sequence:
MAEQHGAPEQAAASKSHGGLGGSYKVTVYELENFQGKRCELSAECPNLTESLLQKVGSIQVESGPWLAFERRAFRGEQFVLEKGDYPRWDAWSSSRRSDILLSLRPLHIDGPDHKLHLFENPAFSGRKMEIVDDDVPSLWAHGFQDRVASIRVINGTWVGYEFPGYRGRQYVFERGEFRHWNEWDANQPQLQSVRRIRDQKWHKRGCFLSS
Protein: Corticotropin releasing hormone receptor 2 (F1NGG4)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDVTISQFILEEFDVNCSLLDLQETVLESFSISFLGFHGLYCNATTDQIGTCWPRASAGKLVERPCPEFFNGIKYNTTKNAYRECLGNGTWASKINYSQCEPILDDKRKYAHHYKIALIINYLGHCISVGALIVAFMLFLCLRSIRCLRNVIHWNLITTFILRNVMWFLLQMIDHNIHESNEPWCRCITTVYNYFVVTNFFWMFVEGCYLHTAIVMTYSTDKLRKWVFLFIGWCIPCPIIVAWAIGKLYYENEQCWFGKEPGKYIDYIYQGPVILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDISQIVFIYFNSFLQSFQGFFVSVFYCFLNGEVRSAARKRWHRWQDHHSLRVRVARAMSIPTSPTRISFHSIKQTAAV
Protein: Auxin response factor 2 (ARF1-binding protein) (ARF1-BP) (Protein MEGAINTEGUMENTA) (Q94JM3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Promotes flowering, stamen development, floral organ abscission and fruit dehiscence. Functions independently of ethylene and cytokinin response pathways. May act as a repressor of cell division and organ growth.
Subcellular location: Nucleus.
Interaction partners:
- Auxin transporter protein 1
- Shaggy-related protein kinase eta
- ADP-ribosylation factor 2-A
- Auxin-responsive protein IAA17
- ADP-ribosylation factor 3
- ADP-ribosylation factor 2-B
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Receptor-like protein kinase HAIKU2
- Probable WRKY transcription factor 10
- Phosphate transporter PHO1 homolog 4
Sequence:
MASSEVSMKGNRGGDNFSSSGFSDPKETRNVSVAGEGQKSNSTRSAAAERALDPEAALYRELWHACAGPLVTVPRQDDRVFYFPQGHIEQVEASTNQAAEQQMPLYDLPSKLLCRVINVDLKAEADTDEVYAQITLLPEANQDENAIEKEAPLPPPPRFQVHSFCKTLTASDTSTHGGFSVLRRHADECLPPLDMSRQPPTQELVAKDLHANEWRFRHIFRGQPRRHLLQSGWSVFVSSKRLVAGDAFIFLRGENGELRVGVRRAMRQQGNVPSSVISSHSMHLGVLATAWHAISTGTMFTVYYKPRTSPSEFIVPFDQYMESVKNNYSIGMRFKMRFEGEEAPEQRFTGTIVGIEESDPTRWPKSKWRSLKVRWDETSSIPRPDRVSPWKVEPALAPPALSPVPMPRPKRPRSNIAPSSPDSSMLTREGTTKANMDPLPASGLSRVLQGQEYSTLRTKHTESVECDAPENSVVWQSSADDDKVDVVSGSRRYGSENWMSSARHEPTYTDLLSGFGTNIDPSHGQRIPFYDHSSSPSMPAKRILSDSEGKFDYLANQWQMIHSGLSLKLHESPKVPAATDASLQGRCNVKYSEYPVLNGLSTENAGGNWPIRPRALNYYEEVVNAQAQAQAREQVTKQPFTIQEETAKSREGNCRLFGIPLTNNMNGTDSTMSQRNNLNDAAGLTQIASPKVQDLSDQSKGSKSTNDHREQGRPFQTNNPHPKDAQTKTNSSRSCTKVHKQGIALGRSVDLSKFQNYEELVAELDRLFEFNGELMAPKKDWLIVYTDEENDMMLVGDDPWQEFCCMVRKIFIYTKEEVRKMNPGTLSCRSEEEAVVGEGSDAKDAKSASNPSLSSAGNS
Protein: Cyclooxygenase-1 (Q9TT27)
Organism: Sus scrofa (Pig)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
SQFVNATFIRDMLMRLVLTVRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPQDCPTPMGTKGKKQLPDAELLSRRFLLRRKFIPDPQGANLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYHLRLFKDGKLKYQVLNGEMYPPSVEEAPVLMHYPRGVPPRSQMAMGQEVFGLLPGLMLYAT
Protein: Mitochondrial pyruvate carrier 3 (MPC3) (Protein FMP43) (P53311)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mediates the uptake of pyruvate into mitochondria.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Mitochondrion inner membrane {ECO:0000269|PubMed:22628558}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial pyruvate carrier 1
- Mitochondrial carnitine carrier
- Translation machinery-associated protein 10
Sequence:
MSASAFNFAFRRFWNSETGPKTVHFWAPTLKWGLVFAGLNDIKRPVEKVSGAQNLSLLATALIWTRWSFVIKPKNYLLASVNFFLGCTAGYHLTRIANFRIRNGDSFKQVIHYIIKGETPAAVAAKQTASTSMNKGVIGTNPPITH
Protein: Eukaryotic translation initiation factor 2A (eIF-2A) (A0A8I6GH40)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRDCPVRGSEGLYMVNGPPHFTESTVLPREPGKNCKVYTFSKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNTIANKLHLQKVNDFNLSPGTQPFKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVAWNPSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSLLYKYDVPSNGELWQVSWQPFLDGIFPAKTITYQAVPSEVPSEEPKVATAYRPPALRNKPVTSSKLHEEEPPQNMKPHPSSDKPLSKTALKNQRKHEAKKAAKQEARNDLAPTPVPQSAPRSTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLELGV
Protein: CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Connective tissue growth-related protein) (Q9R1E9)
Organism: Rattus norvegicus (Rat)
Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P29268}. Secreted {ECO:0000250|UniProtKB:P29268}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
- Decorin
- Actin, aortic smooth muscle
- Collagen alpha-1
- Insulin-like growth factor 1
- Metalloproteinase inhibitor 1
- Collagen alpha-2
- Fibroblast growth factor 2
- Integrin beta-1
- Transforming growth factor beta-3 proprotein
Sequence:
MLASVAGPVSLALVLLLCTRPATGQDCSAQCQCAAEAAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDRTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA
Protein: Spindle assembly abnormal protein 6 homolog (Spindle assembly defective protein 6) (SAS-6) (Q80UK7)
Organism: Mus musculus (Mouse)
Function: Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:38407237}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:24240477, ECO:0000269|PubMed:38407237}. Note=Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis (By similarity). Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (PubMed:24240477). {ECO:0000250|UniProtKB:Q6UVJ0, ECO:0000269|PubMed:24240477}.
Interaction partners:
- Centrosomal P4.1-associated protein
- SCL-interrupting locus protein homolog
- Serine/threonine-protein kinase PLK4
- Centrosomal protein of 135 kDa
- Centrosomal protein 192
- Centrosomal protein of 152 kDa
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- Fanconi anemia group M protein homolog
- Centriolar coiled-coil protein of 110 kDa
- Pericentrin
Sequence:
MSQVLFQQLVPLLVKCKDCEERRGSVRVSIELQSLSNPVHRKDLVIRLTDDTDPFFLYNLVISEEDFQSLKLQQGLLVDFLAFPQKFIDLLQQCMQEHAKETPRFLLQLLSSATLLENSPVLLNVVETNPFKHLIHLSLKLLPGNDVEIKKFLAGCLKCSKEEKLSLTRSLDDVTRQLHITQETLSEKMQELDKLRSEWASHTASLTNKHSQELTAEKEKALQTQVQCQQQHEQQKKELETLHQRNIHQLQSRLSELEAANKELTERKYKGDSTVRELKAKLAGVEEELQRAKQEVLSLRRENCTLDTECHEKEKHINQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVALEENGEKNQIQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEMLQKERKESQDAGQFLRAKEQEVCRLQEQLETTVQKLEESKQLLKNNEKLITWLNKELNENQLVRKQDTLGTSATPHSTSNSTIRSGLSPNLNVVDRLNYPSCGIGYPVSSALTFQNAFPHVVAAKNTSHPISGPKVHFNLQLTKPSASIDGQPGAAVNRPCSNDKENGETLGLESKYLKRREASIPLRGLSQNLLSDSDHQKDGMLGAFQLSSKPTVLPSSSSAYFPGQLPSS
Protein: C2H2 finger domain transcription factor dvrA (Q4WXK4)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Transcription factor that seems to function as negative regulators of virulence by affecting the capacity to damage host cells and to stimulate a pro-inflammatory response.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MTSFLPVNNTSSPQTRPMEEVATAATPRPHTNVSATEENRSRTMNSGTEDATPLNLHKVQEDSASRTKPSLGHNGTSHGESDADRDGSDHDSDAAGNAPPSKKKKGQRFYCTDFPPCNLSFTRSEHLARHIRKHTGERPFQCHCSRRFSRLDNLRQHAQTVHVNEEIPGDSLAATGTRFQRQIRTDRVRPQGRARAGTGGSQGTHSRGHSRNLSTSSIASTTSTYSQPPELRRRPPPLIMANDGSARTRLGLDTMADIPTTPPGQVRGIPGPAVAVGSPYTPSHRLFAAGGNGSPHLASARPAAAHMSGFWDGKTAARRLSVPTSANPFASQQPNNYPPSLVGSATPTTAAYPPGGVFASPVSSTHSFSREENAYSAADADLRRRTWHPSTHFALPRPATSGLSHYQTPDTVDAPVNASGATEQPPRLPGIESFDKVVLHQRPLTPPVRRPSPMQIDSHRKPSPSYALGGGFNYSQPANRPAPPISGPGHRRGHVSWDMSLHTNLTGLHIRDKPLPRDASHWSQQTIAELQNVSSRPSSSYQQQVQESRGITGHSAYEKMQGWYGGHTSGSQATRTSPEDSSSSEGVHTPSTASLEYHPAIVHNSGYIESHPPSMACDTSHSACPPLSQFSDGYQPHVKPDPRPDFYHNASVRDSGMGRLEALVAVATSENKNTAKLYG
Protein: Tropinone reductase homolog At2g29150 (EC 1.1.1.-) (Q9ZW03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Enantiospecific reductase active on cyclic monoterpenes and small flexible lipophilic carbonyls. No activity with tropinone, nitrogen-containing tropinone analogs, tropine or pseudotropine as substrate.
Interaction partners:
- MADS-box family protein
- AGAMOUS-like 99
- At3g12510
- AGAMOUS-like 89
- MADS-box family protein
- MADS-box family protein
- strictosidine synthase
- Protein STRICTOSIDINE SYNTHASE-LIKE 11
- Protein STRICTOSIDINE SYNTHASE-LIKE 2
- AGAMOUS-like 91
Sequence:
MAKAGENSRDKSRWSLEGMTALVTGGSKGLGEAVVEELAMLGARVHTCARDETQLQERLREWQAKGFEVTTSVCDVSSREQREKLMETVSSVFQGKLNILVNNAGTGIIKPSTEYTAEDYSFLMATNLESAFHLSQIAHPLLKASGSGSIVFMSSVAGLVHTGASIYGASKGAMNQLGRSLACEWASDNIRVNSVCPWVITTPLTSFIFSDEKLRKAVEDKTPMGRVGEANEVSSLVAFLCFPAASYITGQTICVDGGASVNGFSFKP
Protein: Protease 7 (EC 3.4.23.49) (Omptin) (Outer membrane protein 3B) (Protease A) (Protease VII) (P09169)
Organism: Escherichia coli (strain K12)
Function: Protease that can cleave T7 RNA polymerase, ferric enterobactin receptor protein (FEP), antimicrobial peptide protamine and other proteins. This protease has a specificity for paired basic residues.
Subcellular location: Cell outer membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized protein YaeQ
- Elongation factor Tu 1
- Elongation factor Tu 2
- Prophage lipoprotein Bor homolog
- Outer membrane protein A
- DNA topoisomerase 4 subunit A
- Cold shock-like protein CspC
- Type I restriction enzyme EcoKI specificity subunit
- PTS system maltose-specific EIICB component
- ATP synthase gamma chain
Sequence:
MRAKLLGIVLTTPIAISSFASTETLSFTPDNINADISLGTLSGKTKERVYLAEEGGRKVSQLDWKFNNAAIIKGAINWDLMPQISIGAAGWTTLGSRGGNMVDQDWMDSSNPGTWTDESRHPDTQLNYANEFDLNIKGWLLNEPNYRLGLMAGYQESRYSFTARGGSYIYSSEEGFRDDIGSFPNGERAIGYKQRFKMPYIGLTGSYRYEDFELGGTFKYSGWVESSDNDEHYDPGKRITYRSKVKDQNYYSVAVNAGYYVTPNAKVYVEGAWNRVTNKKGNTSLYDHNNNTSDYSKNGAGIENYNFITTAGLKYTF
Protein: Ldb1 protein (B2RYF3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
PDRPLAAGRGGPHRAKAGPGRRRGQRGPRAAAAAHAQPVPARGGHRDSAGPPAAGDVKMSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ
Protein: Prostate and testis expressed protein 1 (Q8WXA2)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Prostate and testis expressed protein 3
- Prostate and testis expressed protein 2
Sequence:
MDKSLLLELPILLCCFRALSGSLSMRNDAVNEIVAVKNNFPVIEIVQCRMCHLQFPGEKCSRGRGICTATTEEACMVGRMFKRDGNPWLTFMGCLKNCADVKGIRWSVYLVNFRCCRSHDLCNEDL
Protein: Euchromatic histone lysine methyltransferase 1 (A0A8I6ANQ0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
Sequence:
MLIAIVFCFLPLQQAVLAKQETKQDCCMKTELLREDTLMAADEGSTEKQAGETPMAADGETNGSCEKSGDISHPNAPKHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQNHVTADDFMQTSVIGSNGYFLNKPALQGQPLRTPNTLNSSLPGHAAKTLPGGASKCRTPSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRVHRARKTMPKSILGLHAASKDHREVQDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKVLDDSALHVNGESLEMDSEEEDSEELEDEEDRGAEQAAAFPTEDSRTSKESMSETDRAAKSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACKSSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLANGPDVLETDGLHEVPLCSCRMETPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEETSKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDEKSQSTVTQAPECFDPAGPAGFVRPTSGFSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQENGLPDTSSAAAADPL
Protein: Chromatin-remodeling complexes subunit ngg1 (Kinesin-associated protein 1) (Q9USU8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transcription regulator. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, SLIK and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of a subset of genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Histone acetyltransferase gcn5
- SAGA complex subunit Ada2
- SAGA complex/transcription factor TFIID complex subunit Taf12
- SAGA complex/transcription factor TFIID complex subunit Taf6
- SAGA complex subunit Spt7
- SAGA complex subunit Sgf73
- SAGA complex subunit Hfi1
- SAGA complex subunit Sgf29
- SAGA complex/transcription factor TFIID complex subunit Taf9
- SAGA complex/transcription factor TFIID complex subunit Taf10
Sequence:
MSSEQQNEADSKPAVIPQCFKIENQYETFSRLSETSTPGVVPSVSTLWRLLFELQKMIECEPSCVEYFRQRKEELESHVDSEIETSKDESSVNKVEEKVEEFKEDNVEQEIKQKRSLSESPQESMLEKVSKKPKVSEAHNEEISPENVETIENELDLPVKGKDEQTTGLVYKNANDLLTGSLLSFIVDDSFSYEQKKKLLCVDSFPTSDVRSLVAGTPATDDFSHNKPNNQISISTFYSSLDPYFRAFNDDDIAFLKKGFDVSSSYNIPPLGERYYDLTPEDEMTNLCANSIYQNLQTSAQGSLEAFNEADTVSEEVRCGPLTERLMASLIPCYTQNDEEQKPSIAVGEFAETDSGSEKSKIGTSIDGIESGNNEYTEQPDIQESSLSICEDRLRYTLKQLGILYDGDVDWSKRQDDEISATLRSLNARLKVVSDENEKMRNALLQMLPEEMAFQEFQNVMDDLDKQIEQAYVKRNRSLKVKKKRIVTDKIGSSATSGSFPVIKSLMDKRSMWLEKLQPLFQDKLTQHLGSPTSIFNDLSDHTTSNYSTSV
Protein: Heat shock 70 kDa protein 18 (Heat shock protein 70-18) (AtHsp70-18) (Heat-shock protein 70T-1) (Q9C7X7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Iron-sulfur cluster co-chaperone protein HscB homolog
- Heat shock 70 kDa protein 17
- Heat shock protein 90-3
- At1g54500/F20D21_31
- Thioredoxin family protein
- Chaperone protein dnaJ 20, chloroplastic
- Ankyrin repeat family protein
- Heavy metal transport/detoxification superfamily protein
- Heat shock 70 kDa protein 15
- Heat shock 70 kDa protein 16
Sequence:
MAGKGEGPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPVNTVFDAKRLIGRRFSDASVQSDMKFWPFKVTPGQADKPMIFVNYKGEEKQFAAEEISSMVLIKMREIAEAYLGSSIKNAVVTVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKKATSVGIKNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHFVQEFKRKNKKDISGDARALRRLRTACERAKRTLSSTAQTTVEVDSLFEGIDFYSPITRAKFEEMNMDLFRKCMEPVMKCLRDSKMDKSMVHDVVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQAAILSGEGNEKVQDLLLLDVTPLSLGIETIGGVMTTLIQRNTTIPAKKEQEFTTTVDNQPDVLIQVYEGERARTIDNNILGQFVLSGIPPAPRGIPQFTVCFDIDSNGILNVSAEDKATGKKNKITITNDKGRLSKDDIEKMVQEAEKYKSEDEEHKKKVEAKNGLENYAYNVGNTLRDMGEKLPAADKKKFEDSIEEVIQWLDDNQLAEADEFEHKMKELESVWSTIITKMYQG
Protein: Eukaryotic translation initiation factor 4E-binding protein (4E-BP) (d4E-BP) (eIF4E-binding protein) (4E-binding protein Thor) (dThor) (Q9XZ56)
Organism: Drosophila melanogaster (Fruit fly)
Function: Repressor of translation initiation that regulates eIF4E1 activity by preventing its assembly into the eIF4F complex. Hypophosphorylated form competes with eIF4G1 and strongly binds to eIF4E1, leading to repress translation. In contrast, hyperphosphorylated form dissociates from eIF4E1, allowing interaction between eIF4G1 and eIF4E1, leading to initiation of translation. Acts as a regulator of various biological processes, such as innate immunity, cell growth or synaptic transmission. Acts downstream of phosphoinositide-3-kinase (PI3K) to regulate cell growth. Extends lifespan upon dietary restriction by regulating the mitochondrial translation. Acts as a regulator of lifespan in response to cold by regulating the mitochondrial translation. Acts as a negative regulator of presynaptic release of neurotransmitter in motor neurons: Thor expression is induced in response to insulin signaling, leading to prevent of translation of complexin (cpx), a protein known to regulate the exocytosis of synaptic vesicles. Acts as a negative regulator of synaptic strength at the neuromuscular junction: Thor expression in response to acute fasting prevents translation, thereby suppressing retrograde synaptic enhancement.
Interaction partners:
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- Raptor, isoform B
- Eukaryotic translation initiation factor 4E1
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- Ribosomal protein S6 kinase
- Eukaryotic translation initiation factor 4G1, isoform B
- Serine/threonine-protein kinase mTor
Sequence:
MSASPTARQAITQALPMITRKVVISDPIQMPEVYSSTPGGTLYSTTPGGTKLIYERAFMKNLRGSPLSQTPPSNVPSCLLRGTPRTPFRKCVPVPTELIKQTKSLKIEDQEQFQLDL
Protein: Protein LST8 homolog (Lethal with sec thirteen 8 protein) (Q54D08)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Protein pianissimo A
- Protein raptor homolog
- Ras-interacting protein RIP3
- Serine/threonine-protein kinase tor
- TAP42-like family protein
- Serine/threonine-protein kinase atg1
- Autophagy-related protein 101
- Ubiquitin-like domain-containing protein
- Ras-related GTP-binding protein A
- DNA-dependent protein kinase catalytic subunit
Sequence:
MPGIILATASYDHTIKFWDPPSGGCYRSIDCGEFHINRLEITHDKLYIAAAGNPQTRLFEVNTNNNSPAMSFDGHKGNVTGVGFQKEGKWMYTGSEDGTVKIWDLKAPGCQRDYECSAPVNTVVLHPNQAELISGDQNGSIRVWDLISNTCSRELVPDGEVGITSLTISSDGGLVVASNTKGKCFVWRLGEDDTSRFEPLQKIEAHNAPILKTLFSPDTKLLATCSADHTVKIWNTKKFNVVQTLNGHQRWVWDCAFSNDSAYLVTGSSDHLSRLWDLHQGDAVKTYSGHIKAVNAVALNDLPR