wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium/hydrogen exchanger 3 (G3X939)
Organism: Mus musculus (Mouse)
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Cell membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Recycling endosome membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Early endosome membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity). {ECO:0000250|UniProtKB:Q28362}.
Interaction partners:
- Na
- Na
- Na
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Chloride anion exchanger
- Calcineurin B homologous protein 1
- Ezrin
- Epithelial sodium channel subunit gamma
- Epithelial sodium channel subunit alpha
- Solute carrier family 26 member 6
Sequence:
MWHRALGPGWKLLLALALTSLQGARGAEEEPSSDGSFQVVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSIVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEMLSLSSILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVNPDIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVNVDFNTPRPSTVEASVSYFLRENVSAVCLDMQSLEQRRRSIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKLYKRERAQKRRNSSIPNGKLPMENLAHNYTIKEKDLELSEHEEATNYEEISGGIEFLASVTQDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNSPSNFRRLTPFRLSNKSVDSFLQADGHEEQLQPAAPESTHM
Protein: Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein) (O54880)
Organism: Rattus norvegicus (Rat)
Function: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells.
Subcellular location: Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the exocytic secretory vesicles by RAB27A.
Interaction partners:
- Ras-related protein Rab-27A
- Ras-related protein Rab-3A
- Double C2-like domain-containing protein beta
Sequence:
MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRTQCLSPGEVEVILQVIQRAERLDILEQQRIGRLVERLETMQKNVMGNGVSQCLLCGEMLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPVEPTEPQPQSAEVSRVYTWARGRVVSSDSDSDSDLSSSSLEDRPMPSGIKGTKYDKPRGDSGGSMESPRMGPARPPSHLSGSQSSLGSETGAGATDPQGGTLPRPEPRVSGKRHTWATTHY
Protein: Protein Wnt-8a (Protein Wnt-8d) (Q9H1J5)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Interaction partners:
- Protein wntless homolog
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-8
- Frizzled-5
- Palmitoleoyl-protein carboxylesterase NOTUM
- Wnt inhibitory factor 1
- Cerberus
- Frizzled-4
- Glypican-3
- Low-density lipoprotein receptor-related protein 5
Sequence:
MGNLFMLWAALGICCAAFSASAWSVNNFLITGPKAYLTYTTSVALGAQSGIEECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENCGCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAVRATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAEGHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGRLCTECGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA
Protein: HP1 and insulator partner protein 1, isoform D (M9PID3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEQVSDSAVTTLESTQAEEPPPGVEKVETLELKTAALETLSESAGPTDLENELANLNGSEEGPGLDELSTLEREIAKLHNIRPPDAASEVKDSDTPIALADNGGLEPRQAPDEAKCRTPIIEEGNAASGNGQSSESPLEEVDLIALLKGTDTSHDQPTGEEKCTLEKALSELDGVGEDGDVGVTIEGEGQFEIMEIDDDEGESSSRKASPKVPASKPIKSNSLPSISKHKLSPEQARAVALEQMAGLKPKSRRKEPPAPPSVVAPIDIVSSLNDDWDDYDSEEDKSASALVTEVITLPSAHVVTKKPPLPVKKLSSPVKHSPNSAILLNNKISGVKVMLKTVSQKQLAASTGAAAEKTKPTVVVSPPKETEEHTTGFKRMRVIKRKIIWDPDVPETKKSFAQYASTKAACPAPTTPKTTVKSISPTTTTKKEVAPKKRSATPTARSTKAGTPVGGTERGPSPVKRRAQTPNTGLANGGTQKKKKVSEIDRLMGDEGAANMIHAVEHEQRELSGGEVSNKPLMRKRAMTITGRAARVAVEPTPPKKESAQSAAKRTPADSVFTKATANTSARKPRASDSWDYVYKQRASEESMIMRRRSNSSYSSNASVSRNSLDNRPGAANLSDDAGEGSDPSFKFVKPVSKSSQRGGEDTSSHTLANDMKANNGSELVCLHKVNKVAHLVIHTERGNFGHTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRKDSASQLAVALKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEHSRLFLMGERLFATELLESNSFVDKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGEQWVTADCLANFKRYLNDVDF
Protein: P-type Cu(+) transporter (EC 7.2.2.8) (Q4F8H5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004166}. Membrane {ECO:0000256|RuleBase:RU362081}.
Interaction partners:
Sequence:
MALSTNLCRVTLGVEGMTCGSCVQSIEGRIGGLPGVIHIQVSLEQNNATVTYDHTQHTPQSIADAIEDMGFESSLTNATSTPVQTETKVFSKAGCSADSVQQALSTLAQIKGVIETQESADNQGLAVTFVPSLVSEDQLGEVLKCLAPDTACRPPLSPKEGSTSRSFSGVEAVKMRIEGMVCLSCTTTIEGKIGKLKGVEKIKVSLESQEAAVVYLPYIITVDEIVKQIEVAGFKATVKSKPRQLKLSASEVERLLSAPKQTEEKLSEPPADSTVTTLFQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQVSVVELQKAIEALPPGNFKAIIPASPEPGFLQPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQVSLANHQGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNSLVPSVVKSPSPSVRSSSLSPVRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTATVMDNYDGSDGSLELVVRGMTCASCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASLVKKDRPGSHLDHSREIRQWKRSFQISLFFCVPVMGMMIYMIVVDHMIDKYHQHHNATAEDRAKYHSTMFLEKQLLPGLSIMNLISFLFCVPVQFIGGRYFYCQAYKAVKHRTANMDVLIVLATTIAFTYSVVVLLVAMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLNEDMSVLSEEQVDVELVQRGDVVKVVPGGKFPVDGRVIEGHSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLIKATHVGTDTTLSQIVKLVEEAQTSKAPIQQFADKISSYFVPFIVVISVLTLLAWIIIGFVNFSLVQTYFPGYDKSISEAEAVIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKIQSVVFDKTGTITYGAPKVVQVKMLAEGNRLPRSKLLAIVGTAENSSEHPLGAAITKYCKQELGTESLGTCTDFQAVPGCGIRCLVSNTENLLKREDSDSEENQHNAVLIQISDARAHSTEHPLIMDPQPLTVVQTASYTVLIGNREWMRRNALQVRADVDEAMTEHERRGCTAVLVAVDNELCAMVAIADTVKPEAELAVHVLSAMGLEVVLMTGDNSKTARAIAAQVGIRKVFAEVLPSHKVAKVEQLQQAGKRVAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAADVVLIRNDLLDVVGSIDLSKKTVKRIRINFVFALMYNLVGIPIAAGVFMPVGLVLQPWMGSAAMALSSVSVVLSSLLLKCYTKPTVEKLKRRLGDVRTHGSLSDVSVHIGMGELRRPSPKLSLLDRFVNYSRASINSLRSDKHSMNSMALSEPDKHSLLVGDDHCDNEIV
Protein: Uncharacterized protein (Q382D1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MELDEETNALMRAIKVGGALLIEGHSGNRLRYYYDSFHDLAAQAGVPRAHAPEPLLVTSIESLLRKLRGVTFCHHVFFINTDLCCSQLVGSVLLRRGMSKNLHVLTLHALHHPDPSTLHLLKAMERRDAAAMAELSSFTVATGDASAAPLIIPRRSHDCERALRALNFSHAALAARTTDVHCFCPQWVPMRHRRKWTDMFVLECIFPSDDIADNMLSLRKALEGAVGREVVLLSASEIREKLERAAFCFTFSASERSVVNHLIASAIDAARRNGWILIVQTALPESWDLRERVVHLWRGARVISANGRMGTVQAFDVAQPLSQRLPSFFKQTMWPVVCLDGEACGSVLLPIASPFCTSQVSHVFDLPLRYGAFVTVEELYVTTTPEKRDFRRWIVRPSLFIGQFPLLRCVIASVSSLSQVVLTRPFSWELLLR
Protein: Bacteriocin hiracin-JM79 (Class II sec-dependent bacteriocin) (Q0Z8B6)
Organism: Enterococcus hirae
Function: Bacteriocin with antibacterial activity against the Gram-positive Listeria, Enterococcus, Propionibacterium, Staphylococcus and some strains of Clostridium, Lactobacillus and Pediococcus. Lacks antibacterial activity against Gram-negative bacteria.
Subcellular location: Secreted {ECO:0000269|PubMed:17326750}.
Interaction partners:
Sequence:
MKKKVLKHCVILGILGTCLAGIGTGIKVDAATYYGNGLYCNKEKCWVDWNQAKGEIGKIIVNGWVNHGPWAPRR
Protein: Sterol 3-beta-glucosyltransferase UGT80A2 (EC 2.4.1.173) (UDP-glucose:sterol glucosyltransferase 80A2) (Q9M8Z7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biosynthesis of sterol glucosides. Catalyzes the synthesis of steryl glycosides (SGs) and acyl steryl glycosides (ASGs) which are the most abundant sterol derivatives in higher plants. Can act on several sterols like sitosterol, campesterol and stigmasterol. Both UGT80A2 and UGT80B1 are required for the normal production of SGs and ASGs in seeds.
Interaction partners:
- ceramide glucosyltransferase
- F11M15.8 protein
- UDP-glycosyltransferase 82A1
- UDP-glycosyltransferase 86A1
- UDP-glycosyltransferase 92A1
- Glycosyltransferase-pyrophosphoryl-undecaprenol N-acetylglucosamine transferase)
- Uncharacterized protein At4g19900
- UDP-glycosyltransferase 90A1
- Glycosyltransferase
Sequence:
MPEISPAELAKVSSSSSSSSSSSSGRASVKIEEIEGGAAASGVVIVSEELETNPKTVVASIADETVAESSGTGNKSFSRVWTMPLEGSSSSDKAESSSTNQPRLDKSKTERQQKVTHILAEDAAKIFDDKISAGKKLKLLNRIATVKHDGTVEFEVPADAIPQPIVVDRGESKNGVCADESIDGVDLQYIPPMQIVMLIVGTRGDVQPFVAIAKRLQDYGHRVRLATHANFKEFVLTAGLEFYPLGGDPKVLAGYMVKNKGFLPSGPSEIPIQRNQMKDIIYSLLPACKEPDPDSGISFKADAIIANPPAYGHTHVAEALKIPIHVFFTMPWTPTSEFPHPLSRVKQPAGYRLSYQIVDSLIWLGIRDMVNDLRKKKLKLRPVTYLSGTQGSGSNIPHGYMWSPHLVPKPKDWGPQIDVVGFCYLDLASNYEPPAELVEWLEAGDKPIYIGFGSLPVQEPEKMTEIIVEALQRTKQRGIINKGWGGLGNLKEPKDFVYLLDNVPHDWLFPRCKAVVHHGGAGTTAAGLKASCPTTIVPFFGDQPFWGERVHARGVGPSPIPVDEFSLHKLEDAINFMLDDKVKSSAETLAKAMKDEDGVAGAVKAFFKHLPSAKQNISDPIPEPSGFLSFRKCFGCS
Protein: G patch domain-containing protein 1 homolog (Q21827)
Organism: Caenorhabditis elegans
Interaction partners:
- Coiled-coil domain-containing protein 12
- Pre-mRNA-splicing factor syf-2
- WD repeat domain-containing protein 83
- Golgi apparatus protein 1 homolog
- PWI domain-containing protein
- Splicing factor YJU2
- mRNA transport homolog 4
- Peptidyl-prolyl cis-trans isomerase 4
- Peptidyl-prolyl cis-trans isomerase
- Probable ATP-dependent RNA helicase DHX35 homolog
Sequence:
MNRKKLAAYGQEFEDDDEEGSSVSKKPTQIHEEIATDEKGKRRFHGAFTGGFSAGYWNTVGSKQGWVPQVFSSSRNERGEQIKQRAEDFMDAEDLGEYGIGNRSIKQTAAFGEGAGQKRKMAWERDTTSISTITQMFEDVVKPVSNSIGVRMLRSMGWREGRGIGLANVKQKQKRGGESSEAQFDREQASKVAPAYEFSNEDALVKQLTPLTGTHGIGYQGLRKTTVLNESYGRTTLALKSGKKNSKGIKGQAFGVGAFEEEDESVYSNYDLSQFDFSLDVAGASEESNLKTQKLVTAFELQPKRLNPRKFYAPPRVPPNFRGDHRPIPMDISKLPQMMKNDVKHMNAEQRAKFLGEDRVNALEIGGKSSKKPTERRSRWDIKANEVEKRDNERGGGEAEEDRDRRQRNRIEFPDEPMRQARFKEFLHYIRRGLPYPQPTDLTVWEWEWEKKEFESKLTSDERGMLPEVQSRAQPLAKTAIAAPIHEMMASKFVKEAGGDLKVGTKDEDKLAAVKMEMFGEKTRQSFDWYPDNLLAKRFNVPHPYPGSDTVGVPALQKTDWKRKDRLADIGGVSATLGLPNTANEIEMRERLLKSRAQRGAEEKKRNQSDDDDEKEYDDKDSDEEEENEAEPNNQKVDKAPKSFFDFIFGDGDGADSDESNSEDEEAEEKERQEILKKREEDLKRRREIVEKKEEENRKRVEKELKELENRDLLRVSKQQEDDDIQIIDETSASSFGPALPPSSKPVLSKTEVLKLLEKNMKKKKKDKKEKEKKKKSKKSKKSKKEKKTKRKHSSSSADDSGDNSDGWEEKK
Protein: AMP-dependent synthetase and ligase domain-containing protein (Q54WL7)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Uncharacterized protein
- Nuclear pore protein
- Malonyl-CoA:ACP transacylase
- Malonyl-CoA:ACP transacylase
- Malonyl-CoA:ACP transacylase
- Acyl carrier protein, mitochondrial
- Hydroxysteroid dehydrogenase-like protein 2
- Nuclear pore protein
Sequence:
MSTLYQIFKDTTSRDNKKKLITIPIAKEDSQSFGSLSITYQKFLNDSVSFANKLIEKGIKTGDVVSLVITNGYPILSCFLGSTFARCIAAPLNSAYKSEEFNFYYKDMGANIVIVQKGLSEALKSAKELGIKVWEIENVENEKEGKLYYRITDPSNGDDLIFSSETISGEDEGDKIKLETVPDKDDKALFLHTSGSTGRPKGVPLTHENLATSSANISSTFHLTPSDCSYVVMPLFHVHGLIGVCLSTFNAGASLVVPPRFSASVFWSQVKQFSVNWYSAVPTIHTILCNVEQSATSSASSSNKGLLRFIRSSSSSLSPTLLETLEQFFGCPVIESYGMTEASHQMASNPLPQDGPRKPGSVGKGFNVQISIVNDNGEHQKQGDVGEVCIKGKNVMHGYHNNPQANIDNFTKDGWFLTGDIGYLDQDGYLILKGRKKEIINRGGEKISPLEVDNALLENDKILEAVCFGVPDEKYGEEIWAAVIPKVPQSITVEEITQFLQKKLISFKVPKKIIITDNFPKTASGKIQRRFIADFFLKQQNQ
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q8IQN9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Uncharacterized protein, isoform A
- Palmitoyltransferase
- AT13609p
- CCDC113/CCDC96 coiled-coil domain-containing protein
- AT18358p
Sequence:
MCFMMIGCKYIANANPKRFAKIVHPSAVGFVLVGTVLFFSVEMFYMLPRIYDTDGLFFKIAWLMALFIVYNLLGNMLACHRNSSAVTSLPKDRQIPCPEEKHLWHFCDHCQMLVPPRSWHCKVCECCILRRDHHCIFTATCVGHTNYRYFFWFTVYMHIGSLLSLATHVNLLIIDEQIRRQYVVLHFSRFFLFLKPMSCELIALNISFIINIYACILSLIMLGYQIPALYLNTTFYTPKDYRYNQGLLGNFMAFMGKRGLWTFISPSIRSPLPHDGTKWQTKQAPTTF
Protein: Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2) (Q9H2U2)
Organism: Homo sapiens (Human)
Function: Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:27523597}.
Interaction partners:
- Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
- Potassium-transporting ATPase alpha chain 2
- Potassium-transporting ATPase alpha chain 1
- Inorganic pyrophosphatase
- Potassium-transporting ATPase subunit beta
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase F
- ATP synthase F
- Adenine phosphoribosyltransferase
- ATP synthase peripheral stalk subunit d, mitochondrial
Sequence:
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
Protein: Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (A0A8I5ZZK7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000933}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQEVFRRVSIADPAALGFIISPWSLLLLPSGSVSFTDENVCSQDLRAFTAPEVLQSHSLTSLSDVEKVHIYSLGMTLYWGADHEVPQSQPIKLGDHLNSILLGMCEDVLYARVSVRTVLDACSAHIRNSNCAPSFSYVKQLVKLVLGNISGTDPLSHSSEEKPDRSQAIRDRLRGKGLPIEPVRRYKTYHSDLFSTSSESPSIISSDSDFRQVRKSEASKRFESSSGLPGVDDTVQSRPSRQYETSLEGSLINQEMMLRRQEEEMMQLQARMALRQSRLSLYPGDTIKTSMLDISRDPLREMALETAMTQRKLRNFFGPEFVKTTVEPFASLDLPRSILLQTKKGKSEEQRKKVNIMLLSGQRLELTCDTKTVCRDVFDMVVAHIGLVEHHLFALATLKENEYFFVDPDLKLTKVAPEGWKEEPKRKGKAAVDFTLFFRIKFFMDDVSLIQHSLTCHQYYLQLRKDLLEERIHCDDEASLLLASLALQAEYGDYQPEVHGLSYFRLEHYLPARVMEKLDMSYIKEELPKLHNTYAGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRALVLRFPWRETKKISFSKKKITLQNTSDGIKHAFQTDSSKACQYLLQLCSSQHKFQLQMRARQSNQDAQDLERASFRSLNLQAESVRGFNVGRAISTGSLASSTFNKLAVRPLSVQAEILKRLSCSEWSLYQPLQNSSKEKNDKASWEEKPRGMSKSYHDLSQASLCPHRKQVINMESLPQAFAELVGKPLYPMARSDTESLAGLPQLNNSKSVASLNRSPERRSHESDSSVEDPGQAYVVGMSLPSSGKSSSQVPFKDNDSLHKRWSTVSSPEREITLVNLKKDLKHGLGFQIVGGGKMGRLDLGVFISAVTPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAVDILQNAPEDVTLVISQPKEKPTKVPSTPVHFANGMKNYTKKPSSMQDSAMDPSEDQPWPRGPLRHVPESPFGLSSGLREGSLSSQDSRTESASLSQSHVNGFFTSHLGDRGWQEPQHSSPSPPVTSKITEKTFSDSYRSPARRQGTCDVTELPGCADSDIDDPTYSSSQDRQAPKQEPSSPLKASDKMSFAAFPGPSPEPGDAFEVELAKTDGSLGISVTGGVNTSVRHGGIYVKAVIPNGAAETDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSRERDPASPRCPTPDQDAQSQAPEKMEKQTAHVKDYSFVTEDNTFEVKLFKNSSGLGFSFSREDNLTPELINGSIVRVKKLFPGQPAAESGKINVGDVILKVNGAPLKGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEVNTALLTPLHSPAHAFLNSRKEHSQPSPLSVEQCASSDENGLSGQSKRQCKPPSRRESYSDHSDSGEEESVRAAAKMPNVIPLSAFAPEALRSQGEPASTMFYLPRKIPGKPESESSRLPHPLDVSPGQIRQPPAECAPSDSPGKHLTHLASQLHKEENMTALKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGCYVHDVIQDPAKGDGRLRPGDRLVKVNDADVTNMTHTDAVNLLRAAPKTVRLVIGRILELPRMPVFPHLLPDITVTCHGEELGFSLSGGRGSPHGVVYISDINPRSAAAVDCSLQLLDIIHYVNGVSTHGMTLEEANRALDLSLPSVVLKVTRDGCPVVPCSTRSAISALRPLEANGLSSMEPYGQPALTPKKSFSKVNGDGASGAMCPGGKGLSSPRKKSADLMEARESDSRDDDVYDDPQEAEVIQSLLDVVDEEAQNLLNQTKASRRACSPDPLRTNGEASEDGEDTDCDGSPLPEDVPESVNGGGGKACFASLIQASQEEKPVKEEATQESRESTTETTDREDSSKDPLFLTNEELAALPVVRVPPSGKYTGTQLQATIRTLQGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDTTRVPLGDEGGYINASFIRIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSILGTTTMANERLRLALLRMQQLKGFVVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSHPEDLLTFISYMRHIRRSGPVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEGQYVFCYQVVLYVLTHLQAEEQKAQPGLPQ
Protein: Transmembrane protein 65 (B3DHU2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication. Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q4VAE3}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q6PI78}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes at the intercalated disk in ventricular tissue and cardiomyocytes. {ECO:0000250|UniProtKB:Q4VAE3}.
Interaction partners:
Sequence:
MIRSVLLRALAARPPSAPVPGHLHRCLLGTHRRKIKPEQLELPNQTREFVYSLSPETRSRLLKELQTFESKTEDSGEASRLTAAQLRYILLHNAIPFIGFGFLDNAIMIAAGTQIELSIGLTLGISTMAAAALGNLVSDLAGLGLAGYVEALAVRLGMQIPDLSPRQVDMWQTRVSSHMGKAIGVAIGCILGMFPLLFLSDEEDKKPKKDSN
Protein: Tropomyosin Por p 1.0101 (Major allergen Por p 1) (allergen Por p 1.0101) (M1H607)
Organism: Portunus pelagicus (Blue swimmer crab)
Function: Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Interaction partners:
Sequence:
MDAIKKKMQAMKLEKDDAMDRADTLEQQNKEANIRAEKAEEEVHNLQKRMQQLENDLDQVQESLLKANTQLEEKDKALSNAEGEVAALNRRIQLLEEDLERSEERLNTATTKLAEASQAADESERMRKVLENRSLSDEERMDALENQLKEARFLAEEADRKYDEVARKLAMVEADLERAEERAETGESKIVELEEELRVVGNNLKSLEVSEEKANQREEAYKEQIKTLTNKLKAAEARAEFAERSVQKLQKEVDRLEDELVNEKEKYKSTTDELDQAFSELSGY
Protein: Type 2 glycosyltransferase (EC 2.4.1.-) (I1RB03)
Organism: Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)
Function: Glycosyltransferase involved in the maintenance of the outermost surface of the fungal cell wall. Likely functions in the synthesis of a currently unknown, potentially minor but widespread, extracellular or outer cell wall polysaccharide which plays a key role in facilitating many interactions between plants and fungi by enabling hyphal growth on solid matrices.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Secreted, cell wall {ECO:0000269|PubMed:29020037}.
Interaction partners:
Sequence:
MSESEHQNVGRSPLGFAGPLSLSMPSFDFWYSSTFWLYLFLGLWFHRYFRLLVHCVSHWTYKSKPIPSKPTFTSKDVTVVIPTIHNAFEELRPSLESILACEPAELILVTTHDKRKELQKLADSLVFPKVRVLDTPIANKRLQVCEALPKVETPITIMADDDVTWPSTLMPWILAPFEDPEIGGVGTCQRVRREHDGSWSTKAWNWLGAAYIERRNFEISATHNIDGGTSCMSGRTGAYRSEILSSHDFLHGFKNEKWRKWILNADDDNFVTRWLVSHQWKTWIQYEKECEIETTLENSTKFLYQCSRWARSNWRSNWTSMVTERYIWKQQLWCTYALHFATFTSLAFLIDPLLLASCWWGTADWDMQNRRYAFWSQFVFMFAFTKVVKLMGLFIRNPTDVMFLPVSVVFGYFHGLVKLYALITLNMTSWGSRADGDANDEQRLAPAPQPSIVLKTPPGKGSLIRYNARQKGRQTQAQQVSWEKSDYASYDSSTSYVPIRVHTPMATTPIDTKLYTNESSNTCWAI
Protein: Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25) (Vacuolar protein sorting 25) (Q7JXV9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). Seems to function as a tumor suppressor by regulating Notch trafficking, hence preventing non-autonomous overproliferation. May be involved in the regulation of autophagy. ESCRT-II interacts with bicoid mRNA, which is required for the anterior localization of bicoid mRNA in the developing egg.
Subcellular location: Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting 20, isoform A
- Vacuolar-sorting protein SNF8
- Vacuolar protein sorting-associated protein 28 homolog
- Vacuolar protein-sorting-associated protein 36
- Tumor suppressor protein 101
- Charged multivesicular body protein 4
- RH72336p
- GH14561p
- Charged multivesicular body protein 5
- EG:115C2.5 protein
Sequence:
MAEFQWPWEYTFPPFFTLQPHEETRQQQLKVWTDLFLKYLRHTNRFTLSIGDQNSPLFHNEALKRRLSPELVLAILGELERSGHANPLDKRRQEWQVYWFTLEEYGNMVYDWVQETGQTNTICTLYEIASGENTSHLDFYGVDEAVLLSALRLLEEKGRCELIEMDGSHGVKFF
Protein: Trafficking kinesin protein 1 (A0A8I5Y2D1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEACQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKSCAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEPESPDITHQKRVFETVRNVNQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDVSHVVLDNKTNSILLETEAADLGNEEHNKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLRELAEKGELHSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLAGLATSTTIQHMETSAHHPGKCMSQTNSTFTFTTCRILHPSDELTRVTPRSCEDGGEATICPVELRGDIGQRV
Protein: Kelch-like protein 24a (Kelch-like family member 24a) (Q08BL9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Perikaryon {ECO:0000250|UniProtKB:Q6TFL4}. Cell projection, axon {ECO:0000250|UniProtKB:Q56A24}. Cytoplasm {ECO:0000250|UniProtKB:Q56A24, ECO:0000250|UniProtKB:Q6TFL4}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q6TFL4}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q6TFL4}.
Interaction partners:
- Leucine-rich repeat and coiled-coil domain-containing protein 1
Sequence:
MVLILGRRLNHENSGGVPESPAIKRKVFEMETKTLSDVFNFSSGSSHSESVLQVFNEFRDSRLFTDVIISVQGREFPCHRAVLSACSSYFRAMFCNDHRESREMVVEINGIQADAMDTFLQYVYTGRACITTLNVQFLFETSSLFQITTLRDACAKFLEEQLDPCNCLGIQRFADAHSLKQLASRCRTFALLNFPEVAQHEEFQDLRKDELEEYLASDELSICREEVVFEAVMRWVYHGVEYRRPMLKDLLQHVRLPLLHPNYFVQTVEGDKLIQNAPECYQLLHEARRYHVLGNEMMSPRTRPRRSTGFSEVIVVVGGCERMGGFNLPYTECYDPVTGEWTSLAKHPEYTKSEYAVCALRNDIILSGGRINSSYVWMYNSQLNVWIRVASLNKGRWRHKMTVLLGKVYAVGGYDGQCYLNNVEVYDSFSNRWTEVAPLKEAVCSPAVTSCAGKLFVIGGEPDENSCSNKVQCYDPESDSWQLKACLPFTKPNISAVSLNHLIYVCGGLTKSIYCYDPSQDHWMHVGHTFSRQESCGVSVCNGKIYILGGRGENGEASNNVVCYDPSSGIITSTAAMPRPVSYHGCVTVHRFSEKQHKP
Protein: Neuropeptide SIFamide receptor (Q8IN35)
Organism: Drosophila melanogaster (Fruit fly)
Function: Receptor for the neuropeptide SIFamide. Modulates sexual behavior by playing a role in male sex discrimination. Also involved in promoting sleep.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neuropeptide SIFamide
Sequence:
MMAASGRIRKRKHKSHTSGDVPSTTTSVPMPIPTMAPGKMVAETMEEAAALAGDYNNFTHNFVDLQNLLSFNELNGTSGSGGTAVSSLGSSSAIKLNNSAITDTLLGTVLTTATATVAPAASSLLATLAATTTASARGSLAGKSLAIADATSSTYYSNLLNLSPATTSLISAAAATKSYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQMTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYSVNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAVSYIYEHNSLRRHNMMLKQDSNLSQQMLLKQDSHGSRQFLIKQESSCSDASGIRRPLCQQDSNGSKVSLSKQDSIVSYMEARRSAGHGLNDTLVDRDSVSMDVGRRQGATPSSLLDKRQKFVKQDSVISFVDQRPEQRRHQLVKQDSVISFADQRRGLLHKQDSLMANRTGDAPTHHVSILKKTDSQLSYGSSTSPRRNADLYE