wanglab/gogpt-training-data huggingface dataset:
Protein: Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) (P16066)
Organism: Homo sapiens (Human)
Function: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Natriuretic peptides B
- Natriuretic peptides A
- C-type natriuretic peptide
- Atrial natriuretic peptide receptor 2
- Pro-glucagon
- Guanine nucleotide-binding protein G
- VIP peptides
- Pituitary adenylate cyclase-activating polypeptide
- Pro-opiomelanocortin
- Thyrotropin subunit beta
Sequence:
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
Protein: Spermatid nuclear transition protein 1 (STP-1) (TP-1) (Testis-specific basic protein) (P02317)
Organism: Rattus norvegicus (Rat)
Function: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P10856}. Chromosome {ECO:0000250|UniProtKB:P10856}. Note=Loaded onto the nucleosomes of condensing spermatids. {ECO:0000250|UniProtKB:P10856}.
Interaction partners:
- Nuclear transition protein 2
- Protamine-2
- Sperm protamine P1
- Outer dense fiber protein 1
- Protamine-3
- Spermatid maturation 1
- Acrosin
- A-kinase anchoring protein 3
Sequence:
MSTSRKLKTHGMRRGKNRAPHKGVKRGGSKRKYRKSSLKSRKRGDDASRNYRSHL
Protein: Alpha-L-fucosidase (S2QWF9)
Organism: Lacticaseibacillus paracasei subsp. paracasei Lpp126
Interaction partners:
Sequence:
MTKPSAVNIHRTNPPDWFKQADFGIIIHWGPYSVPAYAPVNIPDYGTLIKTKSLGYLFEHQPYAEWYGNSMLLPNSPVAAYHRTHYGNTSYADFAKTFKQTAQNVDVQAWAEAFANAGAKYVVIVTKHHDGFVMFDPHTKNPYEPDYHLNFDFVGELAQAVRAHGMRFGTYYSSLLDWTFPHLPIKDYGSFLLGNDKSQTYKDYVWHQWHELIDRYHPDVLWSDIGYPDDHRLETLFKYYYQQVPEGLVNDRWQQFPDWMRTSWIRPIFNLVAAQVIKRDRHHSDDLSEVKYYDYRTLEYRTDWPQTNRYFEMTRGMDKSFGYNSLSRPEDYITADDIKQLIAELRSK
Protein: EMILIN-3 (EMILIN-5) (Elastin microfibril interface located protein 5) (Elastin microfibril interfacer 5) (Elastin microfibril interface-located protein 3) (Elastin microfibril interfacer 3) (P59900)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:14706625}. Note=According to PubMed:14706625 it is cytoplasmic.
Interaction partners:
Sequence:
MGRRLSVWLCTVAALLSGAQAKGTPLLARPAQPSASRYSLYTTGWRPRLRPGPHKSLCAYVVHRNVTCVLQEGAESYIKAEYRNCGWGPNCPSTVRYRTVFRPRYKIGYKTVTDLAWRCCPGLTGESCPEHLTDHGATPPHQEPEPQIPLGQLGPGPRPSPYSREAPRPRGRKGQGPFGERLEQRLSQAYGTLSGLVASHENPNRITGDSRAPVVPIGFGVIPEGLVAPEDRGRGPLIPPLSEILSKVTEVSNTLQTKVQLLDEVRGLALGHEAHLQRLREAPPSPLTSLALLEEYVDQRLQRLWGSLLDGFEQKLQGVQSECDLRVQEVRQQCEEGQAASQRLHQSLDGRELALRRELSQLGTQLQGLTLTGGGTCCSQLALISARVDSLERNLQAVTETQGGPGTLAADELARLSAAMLQGGVDGLLEGLETINGTENGARGCCLRMEVGGWGVGGFGSTLEQRVQSLEERLATLTGELSPESAIPDRSARPLVHSELAVLEQRLVSLETSCTPSTTTAILDNLVAEVKAWQSRSEALLHQVARHTALLQQLNGTVAEVQGQLAEGTGSSLQGEITLLKVNLNSVSKSLTGLSDSVSQYSDAFSAANTSLDERERRVEAEVHTIQEQISSQGSRLQAGHRQVLNLRGELEQLKAGMANVARGLSRCRDTAQELQHTVGHFDQRVAQVEGACERLGLLATHLNSLPTEQLRSREGLWGHIDKLNHTLAQHTQDIARLRDDLLDCRAQLAEVRPGRAD
Protein: LD20892p (MyD88 adapter protein) (Myd88, isoform A) (Myd88, isoform B) (Myd88, isoform C) (Q7K105)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH01161p
- Protein Tube
- Serine/threonine-protein kinase pelle
- Protein toll
- RE66324p
- NAD
- Mitogen-activated protein kinase kinase kinase 7
- Protein pellino
- LD40663p
- Dorsal-related immunity factor Dif
Sequence:
MRPRFVCHQQHSVAHSHYQPHSHFHHHTHRHPNPPHHHHIYGATDVSYRRYRTAGMVVAEGVMDSGSGSGTGTGLGHFNETPLSALGIETRTQLSRMLNRKKVLRSEEGYQRDWRGISELAKQKGFVDENANNPMDLVLISWSQRSPQTAKVGHLEHFLGIIDRWDVCDDIQENLAKDTQRFIMKQEQRQTALVEACPPPPSDCFETNNNYSSSNNITVGQSVQILSDEDQRCVQMGQPLPRYNACVLYAEADIDHATEIMNNLESERYNLRLFLRHRDMLMGVPFEHVQLSHFMATRCNHLIVVLTEEFLRSPENTYLVNFTQKIQIENHTRKIIPILYKTDMHIPQTLGIYTHIKYAGDSKLFNFWDKLARSLHDLDAFSIYSTRQVQTPSPVEESAPRVTTPSIRIQINDKDVTDMPNYNSCKVPEAETTIVSVSGDTGSPLPEHKPKKKDRFLRRITHSFGKTARSDGASGKTLRHAHSVSTINVTERERTLSASSSNISTTSESKKSFIKWQPNILKKALFSRSSSKLQTPG
Protein: Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD antigen CD321) (Q9JHY1)
Organism: Rattus norvegicus (Rat)
Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration.
Subcellular location: Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Y624}. Cell membrane {ECO:0000250|UniProtKB:Q9Y624}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9Y624}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000250|UniProtKB:Q9Y624}.
Interaction partners:
- Tight junction protein ZO-1
- Occludin
- Tight junction protein 2
- Integrin beta
- Partitioning defective 3 homolog
- Integrin subunit alpha L
- Cingulin
- Junctional adhesion molecule C
- Claudin-1
- Afadin
Sequence:
MGTEGKAGSKLLFLFTSMILGSLVQGKGSVYSPQTAVQVPENDSVKLPCIYSGFSSPRVEWKFVQGSTTALVCYNNQITVPYADRVTFSSSGITFSSVTRKDNGEYTCMVSEDGGQNYGEVSIHLTVLVPPSKPTVSIPSSVTIGNRAVLTCSEHDGSPPSEYSWFKDGVPMLTADAKKTRAFINSSYTIDPKSGDLVFDPVSAFDSGEYYCEAQNGYGTAMRSEAVRMEAVELNVGGIVAAVLVTLILLGLLIFGIWFAYSRGYFERTKKGTAPGKKVIYSQPSARSEGEFKQTSSFLV
Protein: E1 ubiquitin-activating enzyme (EC 6.2.1.45) (Q3S1J5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDTSNNAGGVGGNSDELLDKNLYSRQIYTLGESAMVNLRTASVLISGLGSVGVEIAKNLILGGVRHVTIHDTKLAKWSDLSAQYYLRDADVGHNRATSCYERLAELNDSVNVQVSTDELTEEFVKTFDLVVLTDAARTAQRQIAAWTRAHNRRILITDARGVFSYIFNDFGDNFRIDDATGEQVREFFIEHIDKTTGEVTTLENLFHGLEDGDHVTFSEVKGLTEINGCEPLKITVKNASKFNIGDFAVSFSDYKEGGRCRQVKVPTSVSHVPFEKSLVEPEFGIWDYAKFEYPSQLHALWTALYAFEEKYGRSPAPRSTQDAALLKELIPSGTEEIPEKLIELFSFSASGNLVTVSSVVGGIAAQEAMKGVTHHMTPLKQWLHLDHVEVLPGDWTSFDNSKLSETDCQPRQSRYDGQAAVFGWPYQECLFRQRWFVVGAGAIGCELLKNLSMMGVACGEGGLIKITDMDQIEISNLNRQFLFRRRDVGGKKSECAARAVTAFNSDVRIEALAERVGLETEHIFNDEFFGELNGVANALDNVDARRYMDRRCVYYRLPLLESGTMGTKGNTQVVYPYLTESYSSSVDPPEKEIPVCTLKNFPNEIQHTIQWAREQFETFFAQPGEMANKFLSDERGFNEHVDKLISGQQIDILQKVKDALIDARPSSAEDCIRWARNQFQELYHNNIAQMLHSFPPDQLTDSGAKFWSGAKRCPHVLNFDPSKEEHFNFVFAASILIAELYGVQPILDREEVIRVALSVNPEPFEPKSGVKIAVTDAEAKEQNERGASSMIVDDDAAIEALKLKLATLNVKSTSKLNCVDFEKDDDSNHHMEFITAASNLRAENYDILPADRMRTKQIAGKIIPAIATTTAAVAGLVCIELYKVVDANGIPKTPMERFKNTFLNLSMPFFSSAEPIGAPKKTYMDREFTLWDRIDVQGPLTLQEFIDNVQNQTGGCEVSMLSAGACLLFSFFMNAGKKQERLKTEVKAVYEELLKKSLHPSVHALVLEPMMSDPDGEDVEVPYIRYSF
Protein: Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) (P70349)
Organism: Mus musculus (Mouse)
Function: Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (By similarity). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (By similarity). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (By similarity). In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (By similarity). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RANGAP1 and RGS17.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P49773}. Nucleus {ECO:0000250|UniProtKB:P49773}.
Interaction partners:
- ATP synthase F
- Cytochrome c oxidase subunit 7C, mitochondrial
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 7
- ATP synthase F
- Cytochrome b-c1 complex subunit 9
- ATP synthase F
- Cytochrome b-c1 complex subunit 10
- Mitochondrial import receptor subunit TOM7 homolog
- ATP synthase peripheral stalk subunit d, mitochondrial
Sequence:
MADEIAKAQVAQPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVADDDDESLLGHLMIVGKKCAADLGLKRGYRMVVNEGADGGQSVYHIHLHVLGGRQMNWPPG
Protein: Eig71Ei, isoform A (Eig71Ei, isoform B) (GEO11781p1) (RT03513p) (Q9VUT2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ecdysone-induced gene 71Ef
- Eig71Eh
- Ecdysone-induced gene 71Eg
- LP23408p
Sequence:
MLKLLLPLAIVCLFMAHIQANPEEANRRHKICIRTYDKCIENEARLGKQDDTSKFFNDYCRRSDSGWSDVSRCDLLRIACLSTVRDCETPTCKNVAHRMRLW
Protein: Predicted gene 4924 (A0A1B0GRK6)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XGAPGIAWYTATHWRELKREWGELGICAMDLVTYEDVHVNFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGYKWEDFNIEEHCKCPKRHERSHHL
Protein: Sentrin-specific protease 1 (EC 3.4.22.-) (SUMO-1 protease 2) (SuPr-2) (Sentrin/SUMO-specific protease SENP1) (P59110)
Organism: Mus musculus (Mouse)
Function: Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (By similarity). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (By similarity). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (By similarity). Deconjugates SUMO2 from MTA1 (By similarity). Deconjugates SUMO2 from MTA1 (By similarity). Deconjugates SUMO1 from METTL3 (By similarity). Desumoylates CCAR2 which decreases its interaction with SIRT1 (By similarity). Deconjugates SUMO1 from GPS2.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9P0U3}. Cytoplasm {ECO:0000250|UniProtKB:Q9P0U3}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9P0U3}.
Interaction partners:
- Small ubiquitin-related modifier 1
- Small ubiquitin-related modifier 2
- Ran GTPase-activating protein 1
- Small ubiquitin-related modifier 3
- SUMO-conjugating enzyme UBC9
- SUMO-activating enzyme subunit 1
- E3 SUMO-protein ligase PIAS3
- E3 SUMO-protein ligase PIAS4
- E3 SUMO-protein ligase PIAS1
- SUMO-activating enzyme subunit 2
Sequence:
MDDTADGVKMDAGEVTLVNHGSTFRTHRPPQSGFPEEQLLLSDQQSLPFRQGTLDGSFTCSTRSPAYRPDYHSDNPSSDSFLGSGDVRTFGQSANGQWRNSTPASGSAPQKPRNSRSLCLETRKTSSGLSNTFVGKSNHHCHMSAYEKSFPIKPAPSPSWSGSCRRSLLSPKKTQRRHFSTAEETVQEEEKEIYRQLLQMVTGKQFCVAKPTTHFPLRLSRCLSSNKNSLKDSLLRNGNSCASHVIGSDTSSSGSASILTAQEQLSHSAHSLSSGTPDVAFGSKDSDPHHHLAAPHQPNSLPASNTQSEGSDSVILLKVKESQTPASSPTFFQAELWIKELTSVYDSRARERLRRIEEQKALALQLQNQRLQEQEHAVLDSVELHLRVPLEKEIPVTAAQETRKKSHQLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGFPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRRKSITYYDSMGGINNEACRILLQYLKQESVDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
Protein: AvrRxo1-ORF2 (Q6TKR9)
Organism: Xanthomonas oryzae pv. oryzicola
Interaction partners:
Sequence:
MKTLTGADALEFHKKLKERNKALHASDLELALVHADAVGKERFDLEELEKICDTSDAGRLTDAKERNDIYERMYYVEYPNVMTLKEFAHIVETLFSWS
Protein: U6 snRNA-associated Sm-like protein LSm7p (D6XGY7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- U6 snRNA-associated Sm-like protein LSm8p
- Small nuclear ribonucleoprotein Sm D2
- Probable eukaryotic initiation factor 4A
- U6 snRNA-associated Sm-like protein LSm4
- Small nuclear ribonucleoprotein E
- Sm protein F
- U5 small nuclear ribonucleoprotein component, putative
- Sm protein B
- Small nuclear ribonucleoprotein SmD1
- H/ACA ribonucleoprotein complex subunit 2
Sequence:
MSAQQAHILKKKESILSLEPHLDRRVVVSLEDREVHGVLKGFDNNINLVLANAEIWNKDVRERQIGACVVRGGLLVSVSSGDTAILQQNPFQ
Protein: Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF) (Q62414)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:10648228, ECO:0000269|PubMed:16730830}.
Interaction partners:
- Neurogenic differentiation factor 6
- T-box brain protein 1
- Myelin transcription factor 1-like protein
- Achaete-scute homolog 1
Sequence:
MLTRLFSEPGLLSDVPKFASWGDGDDDEPRSDKGDAPPQPPPAPGSGAPGPARAAKPVSLRGGEEIPEPTLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN
Protein: Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Stargazin) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2) (O88602)
Organism: Mus musculus (Mouse)
Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein. Synapse, synaptosome {ECO:0000250|UniProtKB:Q71RJ2}.
Interaction partners:
- Disks large homolog 4
- Glutamate receptor 1
- Glutamate receptor 3
- Glutamate receptor 2
- Glutamate receptor 4
- Disks large homolog 3
- Protein shisa-9
- Glutamate receptor ionotropic, NMDA 1
- Protein shisa-6
- Voltage-dependent L-type calcium channel subunit beta-4
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGVKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKDSKDSLHANTANRRTTPV
Protein: Bromodomain and PHD finger-containing protein 3 (Q9ULD4)
Organism: Homo sapiens (Human)
Function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity. Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26677226}.
Interaction partners:
- Histone acetyltransferase KAT7
- Chromatin modification-related protein MEAF6
- Histone acetyltransferase KAT6A
- Inhibitor of growth protein 5
- Bromodomain-containing protein 1
- Histone acetyltransferase KAT6B
- Peregrin
- Inhibitor of growth protein 4
- Histone acetyltransferase KAT5
- Cellular tumor antigen p53
Sequence:
MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFRMVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEEEEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEPTGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLSDNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSPASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSGGLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSYL
Protein: Hat-trick, isoform C (R9PY26)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISVEKIDTGDFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRYDEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVSDKQPGKDGCSKMSPSSGNSTGPGAPSLSGSLGGASSTPSLLSTVVKTPPTGGAKRGRGRSDSMPPRSTTPSSVVAHSGRTKSPAASQPQLQQQMKKRPTRVVPGTTTPRRVSDASMASESDSDSDEPVRRPKRQSAKDKPQAGKAQPPGKGRLASSASSTAPAAHPSDDSEEDEEEEEPSAARAASSKQQQQQASSLRGSRAGGNRAMSSGAASAKGRDYDLSEIRSELKGFQPKLLTNAASNEERKDLAKKEPSDEPALQDIKKEPKLESSAKSSSTELSSETESYADEDSQSSDYRKQLKGSGAGKKEPTASPSKLHHEPVTKRELAVKEEPLKIEPKTEPKEEETKSKPFLSGADIKPTALIAPARFGNTSAAQAASSSGSSSTTAKYTSVIVEKPLTIGGKKSVEQHVPKKAELLKKQSGGAGGTAASSSAASQESKKFAEPVASLKVEMPAACSPSSSSSSSSSFCSTGSAVSSSSATRSLPDMSKLEISSGTVPGATPGAAALQPSNVAQVSSSGAAKESKYSSSGGAAAGSGISMRKLLSSDVYEFKDTEPFEFEKRISPMASVGGTVAAAATAAGAMAAAGAASVITTMVPTPGASGSGVAASASTSAPVVVGSAARKQALKASAIQHILEHQSPAAGRERGGYGGMTSSISLLTAPKLKKRGSPLKEAALCMEKAKTYKLDKDQVQQPVEQKTQQLIQPTLGPVESYGAGSPEAMSNLSTPTTSSGHAQLSASSTYSQLTPHHATPFDALRKSPSFNLNITALNEELAQTVQETTRALTDALQPPSTPVPPTVSASGSTPTAVTPVITAMPTAGTAGLSCPSTPPTGANPVLASPKLSTPPQAINASKQPPASHIVGSPFIETRNVFELSTSNEGSGYSSGESKDNKFEKLENVKILLAGAVGPFDLDAGSYEQKTSSIADKVLKAISQKKEEVENNKGKPPVEPAAAAKTPGREDVVPSPTAKLDLCSSAIKLDTLKLLSEPLKIQTGPLLGELYRPGPATSSPETKSILESSLPAKNSELSETIQKLECAIQQRKTPVGGALSLASSTAGTPPTAHTPNSTATAGAGFSDESMDSTDSEQRLVIEDVIAEEHTTTTTTGEQKSPGSQQEEGQTNTATMATAVTAETEGTSSSTPTPPVPAPVKLELGAKAMPGIQAPIPLKPAEGSSFAGKLTGVVQPPPLAKLQQQEELGQAQGQSKSISSFGIPIVLPEIPASVVVATPALMVASAATVMRHSPGSTPNSQAPVLISPKTFLTAPKVGEVGGLLLKAYTGVSGAVGAAPAGSVIASAGGGGTPTVISNFPQQQQQASVLQASSEMPANYVLDAEMAEPSNSSAPVVARPFVMHAVGKELFNVVAPAASSPLISDPHNESINLLCEETIPGSPAPNYGGTDQLPTAVNSALAIVGITPLPPDTPPPVPVAAIQQQQQHQLQSGQQQQAAKTGEVNPSGPNSSPDSASQDESGEEAKKNAGLEHEDSTGLGALNKRKRNRKPLPMSAQTAAAVAAQLQSLGKRRRQVSGMRNQKTTTTAAGSDTDDNSDNIAPNAGQQQQQPRQSARQHMMPQSNAQQQQQQQLLQQQQTQLPQGIQSTNSSGVRPCPYNFLVELDPALSSDECITILRKQIQDLRKAYNTIKGELAVIDRRRKKLRRREREKKQQQLQSQQQGKICA
Protein: Mitochondrial import inner membrane translocase subunit TIM21 (P53220)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix. In the complex, it acts as an antagonist of TIM50 by reducing preprotein accumulation at the TOM23 complex and promotes dissociation of the PAM complex from the TIM23 complex.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15797382}; Single-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15797382}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM17
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM23
- Protein MGR2
- Mitochondrial import inner membrane translocase subunit TIM16
- Presequence translocated-associated motor subunit PAM17
- Mitochondrial import receptor subunit TOM22
- Import motor subunit, mitochondrial
Sequence:
MSSSLPRSLLRLGHRKPLFPRYNTFVNSSVITHTSLLRTRLYSNGTGATSGKKDDKTRNKPKPLWPQVKSASTFTFSGILVIGAVGISAIVIYLILSELFSPSGDTQLFNRAVSMVEKNKDIRSLLQCDDGITGKERLKAYGELITNDKWTRNRPIVSTKKLDKEGRTHHYMRFHVESKKKIALVHLEAKESKQNYQPDFINMYVDVPGEKRYYLIKPKLHPVSNSKGFLGIRWGPRKD