wanglab/gogpt-training-data huggingface dataset:
Protein: Two-component response regulator, sigma factor PP2C-like phosphatase (Q5DYQ2)
Organism: Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Interaction partners:
- Sulphate transporter, anti-sigma factor antagonist
- histidine kinase
- histidine kinase
- histidine kinase
- Flagellar motor switch protein FliM
- histidine kinase
- Aerobic respiration control sensor protein
- Autoinducer 2 sensor kinase/phosphatase LuxQ
- Flagellar hook-associated protein 1
- histidine kinase
Sequence:
MNSTLLFSDTKPTSLESVRVLRQSLSKILKNLEINTTVLNQCLLCFSEWSTNLVLHPIQPSKNISLTLRKSNSHWQIDIIDDGIPWDPTEQHKESELSEFSLKCGGRGIDIIQDQTDDIRYKSTIENNTLSLLWERSPSHKHPHILIVEDDAIQSKLLQAYLKSNFSITATTNGREALQFLQHNTVDLIISDIQMPEMSGLELRSQLEKENNFSIPFIFLSNLQDTNTVNCAAELGIDDFLQKPVQKTQLIHSITRVLGRFHQVYHALSEQLNQKIAHTLLPQVEAHSDKWKLITQQRTVGQGGGDFTLSRANNNNTLLLLADVMGHDESAKFFAYAYAGYVRGLMQHADLTQPSQLLSQLSNNAFKDQLLSQTMLTTCCLSFIGDDTIKISSAGHPKPLHITPRGINIIEIEGTLPGLLPTTHYKETTISMKYGERLALFTDGLFESGDTISERDTLEKAIKKQLIETLHLPIEQAINQIIKTFDALAGTPPNDDALLLLIENQ
Protein: Type IV collagen alpha 6 chain (Q9ESQ1)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
Interaction partners:
Sequence:
MHPGLWLFLVSLCLTKELAESGQKMSYGKPCGSRDCHGVCTCFPEKGARGHPGPIGTQGPAGPEGFTGPTGLSGLKGERGSPGPLGPYGSKGDKGPIGVPGFVGISGIPGHPGQPGPRGPPGPDGCNGTQGAVGFPGPDGYPGILGPPGLPGHKGAKGEPVPFQGSITGIRGDPGLPGLDGIPGPSGSSGSPGDAGPIGPPGLQGPPGLPGLPGPEGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPPGFPGMSGPPGVPEFGSTGEKGEKGILGLPGPRGPMGSEGIQGHPGRQGKKGTSGFPGINGFPGIKGEKGDIGVRGPDSFTDADGAVISGYPGDPGVLGLPGLRGDEGVQGQRGPSGTPGLPSLTGLPGALGPQGFPGLKGDQGNSGRTTFGEAGLPGRVGLPGLPGLPGPSGPPGRTFETGHLSNIEPGFPGLQGEQGPKGHQGLKGVKGDSGFCACEGGPPNIGPHGEPGLPGIQGPIGLQGFKGTKGDPGSRGASGPAGTPGLFGPRGQTGLKGKKGEPTVSRGSKMSGDKGDPGPQGTPGLAGTPGKDGRPGLPGLPGIQGDGGSGFPGERGLPGLPGEKGHDGPIGPPGIGLPGPPGPRGLPGDKGVDGLPGQQGLRGAQGVTLPCIIPGSYGPSGFPGAPGFPGSKGARGLPGIPGKPGTHGSKGGPGSPGLMHLPGLPGFPGVRGEKGLPGFPELPGKDGYPGKAGSPGLPGFKGAAGDIFGAENGASGEQGLQGLPGDKGFPGDSGLPGPKGLNGKPGMLGPKGERGNPGTSGPPGQPGPSGSTDPFGIKGTSGFPGAPGLPGISGHPGKKGQRGDIGQPGSTGKRGLPGIKGLPGPQGSPGFLGSPGLSGVTGLPGIEGQKGEKGSSGPVGFPGLPGLPGLPGADGLKGFSGSFGKVGQPGQTGTSGEKGDRGDPGPVGISSPRPPMLNLWFKGEKGSRGSAGSDGFPGPRGDKGEPGIPGLPGPPGATGQTNTIKGLNGRPGSPGSMGRRGLPGLKGSLGIAGFPGMPGKSGSQGLTGTSGLLGATGIPGLKGDQGQTLGISGSPGPKGQPGELGFKGVKGKDGLVGDRGYPGNKGDGGKVGITGDPGFPGSPGLQGISGMNGDPGLPGSSGHLGSIGRPGPSGLIGPKGFPGAPGLHGLNGLPGTKGTHGTPGASITGVPGPAGLPGPKGERGVPGIVIGDPGKQGSKGQKGDQGSPGLQGPAGTPGAPGISLPSVIAGQPGDPGRPGLDGERGRPGPPGPPGPPGPSSDQGDPGDSGFPGIPGLQGFKGNQGLPGFSGLSGELGLKGMRGEPGLMGTPGKIGQPGDPGFPGMKGKAGPRGFSGPQGAPGHTPIAEAMQVPPGPLGLPGIDGIPGLIGDPGSQGSVGLQGSKGLPGIPGKDGPSGLPGPSGILGDPGLPGLQGPPGFEGAPGNQGPIGQPGMPGHGVRVGYTLVKHSQSEQVPLCPTGMSRLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVGQTQIPQYISRCSVCEAPSQAIAVHSQDIIVPQCPLGWHSLWIGYSFLMHTAAGAEGGGQSLISPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERGQFREEPVSETLKTGQLHTRVSRCQVCMKTP
Protein: Pumilio homolog 5 (APUM-5) (AtPUM5) (Q9LJX4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Pumilio homolog 23
- Gamma-aminobutyrate transaminase POP2, mitochondrial
- Serine/threonine-protein kinase-like protein CCR4
- Protein OBERON 4
- Putative pumilio homolog 25
- Protein BTR1
Sequence:
MTTTQSAMRMVEGDHIKNWQASSDSGIFGSLDMAVEDLGFLMKRNRLDSGDQTGKFPSRSESAPPSMEGSFAALRNLLKQQEGSSSEVLSRAIENYDSEEEIRSDPAYVAYYLSNINLNPRLPPPLISRENQHLLRHFGDNNQSPTTSWDNMGIRSSLHSSRTALSTHREEPEDEASSGEQQSYASLAGRRKSIADMIQEDFPLTLSSVFKRPHSAGNRPIAQDIHAISSDTSSEHARRLPESDINSVNLLRETDSLSSDAIASEDPFTTDLASQSFTNAQTERLNARQASHEDNNLSVFGASPPSSVASRMRRNQEDQQSQGRRMPPQYTPSSYQVQASSPQQMSYPRIGGTQDMMQSLPKIATGEVHSTFQSPHGLAPPPMYTSTAAYMTSLSPFYHQNFQSSGMFVPQYNYGGYPPASGIVPQYMSGYPSHEATVPMPYDISSTSSGYNNPRLLPGVSSSGQNIPSLVDPFQLQYFQQAQVDAYAPPFQSSTDSFGQKDQQAVGYMANHEPLNSPLSPGYGLQSPRHMGNYFAVPPGVRVMPQYPGSPLASPVMPSSPVGGMMSHFGRRSETRYHQQGPSRNTGIYPGGWQGNRGGASSIVDDLKRHSFLDELKSPNARKLELSDIAGRVVEFSVDQHGSRFIQQKLEHCSDEEKASVFSEVLPQASKLMTDVFGNYVIQKFIEHGTPAQREELVKQLAGQMVSLSLQMYGCRVIQKALEVIDVDQKTELIRELDGNVLKCVRDQNGNHVIQKCIESMPAGRIGFVIAAFRGQVATLSTHPYGCRVIQRILEHCSDDEETHCIIDEILESAFALAHDQYGNYVTQHVLERGKPDERRQIIEKLTGNVVQMSQHKYASNVVEKCLEHADSTEREFLIEEIMGKSEEDNHLLAMMKDQFANYVVQKVLEISKDQQREILVQRMKIHLQSLRKYTYGKHIVARFEQLFGEESEVSEEGTEG
Protein: Pupal cuticle protein (P14484)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the cuticle of the pupa of fruit fly.
Interaction partners:
Sequence:
MYLLVNFIVALAVLQVQAGSSYIPDSDRNTRTLQNDLQVERDGKYRYAYETSNGISASQEGLGGVAVQGGSSYTSPEGEVISVNYVADEFGYHPVGAHIPQVPDYILRSLEYIRTHPYQIKDYYTGELKTVEHDAAAFNVYTRNIQDHTIPQSRPSTTPKTIYLTHPPTTTSRPLRQRRALPTH
Protein: Septation initiation network scaffold protein cdc11 (SIN scaffold protein cdc11) (Cell division control protein 11) (O74473)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for the onset of septum formation. Involved in the organization of astral microtubules during mitosis. Acts as a bridge between sid4 and the other SIN proteins mediating their association with the spindle pole body (SPB). The sid4-cdc11 complex organizes a signaling hub on the SPB which coordinates cell and nuclear division.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes at the spindle pole body and the barrier septum.
Interaction partners:
- Septum-promoting GTP-binding protein 1
- Cell division control protein 7
- Septation initiation protein sid4
- Cell division control protein 16
- Serine/threonine-protein kinase sid2
- Maintenance of ploidy protein mob1
- Serine/threonine-protein kinase sid1
- Protein byr4
- Spindle pole body protein ppc89
- G2/mitotic-specific cyclin cdc13
Sequence:
MEQLWLEHDLSEEWIPQPQEQGSDNSSEPPTTSNVNNTQSTGRGSSGTSTEHGTFKKGRNDAPDVPQWKQVNAKNPVARDIFARLDLENMFEESSKQSPPSKSPTKNPSKKSSNNSSRRSSSSVGKLSNVSNMQSSPSKDPFVSQDYEKESISSSQFSKKYSEGSLKSQQSNTRSNSVHEKQNTDHASNASSSSSVVSSPSLKPNNTSPLKLFQGASDPFTREHLNQLTQDVKSNSFENGEKQFSLPEPRRPQKPMRTTERKASLNTKDLYQEVEEVMARLRGRMPNSGRESTIFLPRKLSGLREEEEQDEISVEVSQEDSSNAFPSLSDQLHLKSLQSMKRVTSIFNDNDDSFPSASSSPQRQAYMTDKMPLREIDVGSSQSSSKTARLNSSPKSTLKTSSVKTRRSHSAQSSRKVSDYPNMVVITPADLPEGIDTTQGSMEFDRIHNRWRRKGHDSDLGFDFETDEDASLSHPERTILFKAASTRHQANNDPNNLEKQQPHSFPLRKQNVAQSEFPKHSLRDNSENAPQILSSFHDLSLQNESFDEMFNGRYENGSPIPFISSGSGLKSKADKDAEYSFSVSRQSIIQILSDVEPYEPFWKRIIQLDISRRHLDSLIGLSELCPSIEELTLEGNEIAYLTGCPVTIRDLNAVENRLSSLTSFSNLLNLQYLDISYNQLEDLTGLSSLIHLRELKVDSNHLWSLDGIQHLDGLLKLSACNNRIKELSFTNSNLHRLEELLLGNNEIEEIEEISSLQNLMVLQLDNNKLTNLKASQPMIHLRILRISNNAIHQLEVDQFPHLRTLYMDLNRFNRPPDIRRLKRLVNFSFRTQDPEASNFVIQPSLDIRNLYLSNNTFVTLDCKHMFLGVRYLELANVQLKEVPKYIATSMPNLRVLDLSHNYISDIESLKPLQMIHRLYLVGNRIKKMRNLCDILANLKQLNVLDLRMNPLNFNIYPVIDDSIYELSAASKYQQSINQKGHHRKEDPQKQWQEKELAFSSTLSEAWRTRRKMYAEAILLACPHLEWLDGSDVSQSSRAAFTKSSN
Protein: Protein AC109 (P41662)
Organism: Autographa californica nuclear polyhedrosis virus (AcMNPV)
Function: Plays a role in the transport of the budded virion (BV) to the host nucleus and for occlusion of viral progeny.
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:23049963}. Host nucleus {ECO:0000269|PubMed:23049963}.
Interaction partners:
Sequence:
MECPFQIQVCISDRFFAFPHNLVEPQSDVGNKLIENLIVYVPTDDDRLYIDKKQFPKFNSVLVYRHEHDVNIDSRSPKKTASATIVYWNPLVPITEIGAGETRVFSVLLTNNLFYCNTMIVHHENPKCPIEFTYPETDMQSACSALLKNRNGQSVPPPIKSNLRPIACEIPLSHFKELVESNDFLLCFNLETSTMVKILSLKRIFCIFQYRKQPARYVINLPHEEIDNLYNKLNWERTRRLMKGDVPSNCATVNRSSLKYIKQAQSLLGIPDYSQTVVDFVKMFQKIIFPYQLVPNVIIKLNNFDQMVSSAPNKAEPYKKIRLFCKNDSIAISSSGIVPINMPDFSPPNTFDYSDYANRTNINFVTQRVLTDGGFSSGITVTPVKYNYYL
Protein: Cytochrome d ubiquinol oxidase, subunit I (EC 1.10.3.-) (Q7D892)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MNVVDISRWQFGITTVYHFIFVPLTIGLAPLIAVMQTLWVVTDNPAWYRLTKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDVFGAPLAMEGLAAFFFESTFIGLWIFGWNRLPRLVHLACIWIVAIAVNVSAFFIIAANSFMQHPVGAHYNPTTGRAELSSIVVLLTNNTAQAAFTHTVSGALLTAGTFVAAVSAWWLVRSSTTHADSDTQAMYRPATILGCWVALAATAGLLFTGDHQGKLMFQQQPMKMASAESLCDTQTDPNFSVLTVGRQNNCDSLTRVIEVPYVLPFLAEGRISGVTLQGIRDLQQEYQQRFGPNDYRPNLFVTYWSFRMMIGLMAIPVLFALIALWLTRGGQIPNQRWFSWLALLTMPAPFLANSAGWVFTEMGRQPWVVVPNPTGDQLVRLTVKAGVSDHSATVVATSLLMFTLVYAVLAVIWCWLLKRYIVEGPLEHDAEPAAHGAPRDDEVAPLSFAY
Protein: Multidrug resistance protein 2 (EC 3.6.3.44) (Q8IKZ6)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Chloroquine resistance transporter
- Ferredoxin, apicoplast
Sequence:
MDVSNYEYLRSYGIKNELKRKRTHKKIIIYHLLDIIIFFLLFFSCYNFNLELCYKYEKAIFYNFFKSSVDLFLLNVIRIIYTVILFRLHKKLTELNTLGKVYVLSRHITGILVILNVIKMINYSYVIKSENPLYNTNMYLITLKVLFMVYSMISSIYYYFIQFKLYNIKKKYIIARVELEKILINDIKSKKYNIYKSDENSGLLGTDSNSTIMNNEYLNLDYKNLLDMNISYNKLNEKINNDIINNTSDVQEKNMDYNDIHNFQKKKKSSNFAYLNFFHKESKDNKIDVKESFLNKRYGSNKRSSKIYDNNNNNNNNNINSKIDYLENNITYTEFKKILLPYLWPSKRIDMKGNSSILRTYIVLIFLFILVSKVFSVISPIYLGWASNEVLKKSLSSSVYYLGLYVTFFFISKFLKEVCGVLFSQVQQSAFIELQESIFQTFHNLSYEWYSSKNSGGIMRIVDRGTESANNLMSSVLMYIIPATIEGLITCIIFIFKYKNSLLGSVLFIGLTLYIYSTIKITKWRKKIRTKANEMDNVYHDIAHDSLTNYENVKYFSNEKFEIKKFCNALSNYHRYNLKILNSLGILNTVQQFILNGTLFFTLLCVIYMIVKEGSDPGTFISVVVYTSNVFAPLSILGTLYATIIKSFTDISDLIDILRDKIDISNDKNLKNFDLTSQEKKFGVSIEFNNVHFNYPTQPLHTSLKDINIYIKPGTTCALVGHTGSGKTTISKLLYRFYDSKGEIKIGGRNINEYTRNSIRNIIGIVPQDTILFNESIKYNILYGKLDATEEELIQAVKSAQLYDFIQSLPKKWDTLVGDKGVKLSGGERQRISIARCLLKDPKIVIFDEATSSLDSRTEYLFQKAVEDLRKNRTIIIIAHKLCTITTAELIILLNKGKIIERGTHLDLLKCNGEYTEMWNMQSKSNEPHTETNSSIDKDDVNKNNNKNNDVILNTCKNDITTSFRSNSEKSSQEFSDASNHIKQSKTSNDHNNNINVHKKNEQEQLFLTNDKTDMDDNMNNKKK
Protein: Small ribosomal subunit protein eS21A (40S ribosomal protein S21-A) (S26) (YS25) (P0C0V8)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eS21 is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14627813, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS19
- Protein LTV1
- Small ribosomal subunit protein uS8A
- Small ribosomal subunit protein uS5
- Serine/threonine-protein kinase RIO2
- Small ribosomal subunit protein uS2A
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein eS25B
- Small ribosomal subunit protein eS25A
Sequence:
MENDKGQLVELYVPRKCSATNRIIKADDHASVQINVAKVDEEGRAIPGEYVTYALSGYVRSRGESDDSLNRLAQNDGLLKNVWSYSR
Protein: Uncharacterized protein (Q9W4M4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Chorion protein a at 7F, isoform A
- Chorion protein c at 7F
- Chorion protein S36
- IP19013p
- GEO10373p1
- Chorion protein S16
- IP19005p
- Uncharacterized protein, isoform B
- RE05851p
- FI16876p1
Sequence:
MWRLHLFLLLSTCFLVPHDAKPTKRSPVGFSSTTLVSLLLETETGNGTTDVPTTTETTTLRTQRVTNIGRLASKDLADLLLASMQARGAKLTSSQESTMKSLRTEEGKDTKGNNVFLQIGMDVIIDILIGARDNATCGRIIQDIDQSQDRNTLTLTLKSFLALCVFNGIECAKDEVSQVIKSTHFRQKQQIKIVHDDNDHQQSEGSGLRTARRVGVIKDDRNSVLKFLQARNIKELSTILNTLLKLCGASGGEAHKIIRNLREMGPDNVSLLQVNAFSMLSVSLLDSLSTIAEGKISGLCSASPESWIVRLLAMGVDKVVLMGLMTALDRTIVNSSSAEMTNAAALNSINGGDFSNSKSKVDQKTAAKRAILDSGSGNDFNLAPSVEEIGNLNTVNDLINANVPVGANLPVLSTIDGSSSSGNTLNQSSDVVLDGDSNNFNRLVGAKIPVLANAPILSNINGGSGSGGVGNNFNLAPSVQEIGDSNTVNDLINANVPVGASLPVLSSIDGSGFSGNTLNQGTDVLVNGTGNTFNRLVGARIPVLANAPILSSINSGSSGTSGSSSSGSSSSGSSSSSSGSSSGVGNNFNLAPSVQEIGDSNTVNDLINANVPVGASLPVLSSITGSGFTGNTLNQGSDVLINGTGNTFTRLVGARIPVLANAPILSSINSGSSSTSSGSSSSGSSTSSGSSGSSTSGSSGSGSTSSSSGTPSSSGSSVLGNNVNVKGDTITGNKNFLFKLLDLGLPISLAAPVLSIINQGSSTGSSTGSSTSSSTGSSTGTSSGSSTGSSSGSSGVTSTGSSNSTSSGASVGNNANIDPSVDIVGNNNQVTKVVDANVDALANVPVLSKITGTGFANNLNQKSNVLIRGDNNTVTKVVDANVPVLAAVSALSSITGKSSGSGSSSGSSGSGSSSGSSGSGSSSGSSGSGSSSSGLLSGLTGSSGSSSDGLLGGVLGGVVPVVGEVVGDVVQAVGPVLGGVLNTVEPVLGGVLNTVEPVLGGVLNTVEPVLGGVLNTVEPVLGGVLNTVEPVVGDLVGGVLSGVTGSSSSSSSSLSGVTNLLGGSSSSNGSSSIIGNSASSGANTLITGNNNNIVRLVDVNGLVLADIPILSSITNLLGVTGLIGNSANKGPKTVVIGDNNRIVKLINVDLWVLAFLDVLNIVRGSGGVCNQLNSGPNTEIIGNNNDVVQLVDVDLSVLLVVDLLSHLITNVANDCSGKTTTVAPTQSPTESPTESPTGSPTDSPTQSPTETPTYGPPTNEPPTNQPPTNQPPTVQPPTNQPPTNQPPTNQPPTNQPPTNQPPTNQPPTNQPPTNEPPTNRPPSPSPNNCYRRYCRKWRTRPSYLCYKNCGGAFVYKP
Protein: Polycomb protein EED (Q921E6)
Organism: Mus musculus (Mouse)
Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.
Subcellular location: Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in cells of the early embryo and in stem cells of the extraembryonic trophectoderm lineage. Recruitment to the inactive X-chromosome requires XIST.
Interaction partners:
- Protein Jumonji
- Histone-binding protein RBBP7
- Histone-lysine N-methyltransferase EZH1
- Histone-lysine N-methyltransferase EZH2
- Zinc finger protein AEBP2
- Polycomb protein Suz12
- Histone-binding protein RBBP4
- E3 ubiquitin-protein ligase RING2
- E3 ubiquitin-protein ligase RING1
- PHD finger protein 1
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
Protein: Angiopoietin-like protein 8 (Betatrophin) (Lipasin) (Refeeding-induced fat and liver protein) (Q6UXH0)
Organism: Homo sapiens (Human)
Function: Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:23150577}.
Interaction partners:
- Angiopoietin-related protein 3
- Angiopoietin-related protein 4
- Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
- Lipoprotein lipase
- Angiopoietin-related protein 1
- Apolipoprotein A-V
Sequence:
MPVPALCLLWALAMVTRPASAAPMGGPELAQHEELTLLFHGTLQLGQALNGVYRTTEGRLTKARNSLGLYGRTIELLGQEVSRGRDAAQELRASLLETQMEEDILQLQAEATAEVLGEVAQAQKVLRDSVQRLEVQLRSAWLGPAYREFEVLKAHADKQSHILWALTGHVQRQRREMVAQQHRLRQIQERLHTAALPA
Protein: CAAX prenyl protease 1 (EC 3.4.24.84) (A-factor-converting enzyme) (Prenyl protein-specific endoprotease 1) (PPSEP 1) (P47154)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Proteolytically removes the C-terminal three residues of farnesylated A-factor mating pheromone. Also acts to cleave the N-terminal extension of the pheromone. Does not act on Ras.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9736709}; Multi-pass membrane protein {ECO:0000269|PubMed:9736709}.
Interaction partners:
- CAAX prenyl protease 2
- Protein-S-isoprenylcysteine O-methyltransferase
- Uncharacterized protein YIL029C
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Protein farnesyltransferase subunit beta
- Putative protease AXL1
- A-factor-processing enzyme
- Mitochondrial metalloendopeptidase OMA1
- DnaJ-related protein SCJ1
- Protein transport protein SEC61
Sequence:
MFDLKTILDHPNIPWKLIISGFSIAQFSFESYLTYRQYQKLSETKLPPVLEDEIDDETFHKSRNYSRAKAKFSIFGDVYNLAQKLVFIKYDLFPKIWHMAVSLLNAVLPVRFHMVSTVAQSLCFLGLLSSLSTLVDLPLSYYSHFVLEEKFGFNKLTVQLWITDMIKSLTLAYAIGGPILYLFLKIFDKFPTDFLWYIMVFLFVVQILAMTIIPVFIMPMFNKFTPLEDGELKKSIESLADRVGFPLDKIFVIDGSKRSSHSNAYFTGLPFTSKRIVLFDTLVNSNSTDEITAVLAHEIGHWQKNHIVNMVIFSQLHTFLIFSLFTSIYRNTSFYNTFGFFLEKSTGSFVDPVITKEFPIIIGFMLFNDLLTPLECAMQFVMSLISRTHEYQADAYAKKLGYKQNLCRALIDLQIKNLSTMNVDPLYSSYHYSHPTLAERLTALDYVSEKKKN
Protein: PDZ domain-containing protein C23G3.12c (Q9P7S1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MSIKKRARAGSKSDDIGNKTPKKNGIEHEATKSSETVIEMTPSGPIAESKKWKESIARVVKSVVSIRFSQVAAFDTDESGTGEASAFVVDAKNGYMLTNRHVVCAGPFVGHAVFDNHEEVEVFPVYRDPVHDFGFLRFDPKKIRYMNVEQLELRPDLAKVGTEIRVVGNDAAEKLSILAGWISRIDRNVPDYGELTYCDFNTNYIQAAANASGGSSGSPVVERNGNVVALQAGGHMIAATDYFLPLDRPLRALRCLQNNTPITRGTIQAQFLIKTFDECSRLGLDSAMEEKVRTLFPEATSMLVVETVLPEGPSFKKLKEGDILLYVNSMILINLIELESILDESVGKDVVLTVQRGSELVELTCTAQSTHDIAPDRYVEVCGAKFHNLSYQLARQYALPVKGVFISEPAGSFRLEGPEYGYILDSIAYKPVPDLDTFIEVMRDIPDRSRVAVGYHFIHDKHSLITDVVEIDRHWLKAFRMVTRNDETGLWDFKNLGDPLPAEPSKPCTTSIPKLNVENFGPTANIINCFVKVLYYMPLHLDGSRKSRKKGTALVLDKDKGLAVTSRSTVPYDLGDLTITVADSIQIPAEVVHLHPTQNLAFIKYDPKLLGDTPIQAAKLKDYYVSQGDPVNFFGFNSKSRVVAAKTSVTDVITMVIPSSPMPRFRAINFESITVESNLSTQCGSGVLTDDDGLVVALWLTHYGEQTSRGTDVKYHLGLASPVVLSTLRRLQSGVNVNPRILNVEFRAIQLAQARSLGLPAERIRKIETESGKKHQLFMITHVEAGTPRILTDGDIIISANGKSITRIRDLQVDDVTEVDMEILREGKVQTVKVPTFPSDNCETNRVVICWGATLQAPHRAVRLQIEDLPSNVFVTNRGRGSPADQYDLGAAQFITAVNGVTTLNLEDFVREIRKIDDNSYVRVSTSTFDKVPVVLTIKMNKHYFPTIDLVQDAKAENGWRAVQYDEVGEKKNPSMGFTIDEEVDDNTFDTEGEQQ
Protein: Eyes absent homolog (EC 3.1.3.48) (A0A0G2JZ01)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- SIX homeobox 1
- Thyrotropin subunit beta
Sequence:
RLPRKRKTVCEDRRDLQSSHISVCKETAVLMEEEQDLPERPVKKAKMQEPGEQTLSQVNNPDTSDQKPETASLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFGALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIPASSTNASLISTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDTENTALAATTYQTEKPGAMGPAPATQRLPSDSSTSPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
Protein: Ubiquitin thioesterase otu2 (EC 3.4.19.12) (OTU domain-containing protein 2) (Ubiquitin specific cysteine protease) (Q9UUK3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:20838651}.
Interaction partners:
- Putative ubiquitin thioesterase otu1
- Probable ubiquitin carboxyl-terminal hydrolase 4
- Ubiquitin carboxyl-terminal hydrolase 14
- Probable ubiquitin carboxyl-terminal hydrolase 2
- Probable ubiquitin carboxyl-terminal hydrolase 9
- Probable ubiquitin carboxyl-terminal hydrolase 1
- Probable ubiquitin carboxyl-terminal hydrolase 3
- Probable ubiquitin carboxyl-terminal hydrolase 7
- Ubiquitin carboxyl-terminal hydrolase 15
- Probable ubiquitin carboxyl-terminal hydrolase 1
Sequence:
MEELLSKQREECKELQSKITNLRKQLKEGNKKQKRALQQKISQMEADLSQKHATERQKLDKGDEETNETQQEDLLNTLLQQMEDTKITTAEKSSVQSSLNTKENTPQQPKKSRNRQKERLERRKAEMKKMSEQAELESEKMADLKNEEKKKFSKILEEAGLVAVDIPADGNCLFASISHQLNYHHNVKLNSQALRNKSADYVLKHCEQFEGFLLDEESGEVLPVSDYCNEIRNNSKWGSDIEIQALANSLEVPVHVYNTEGPVLKFNPSTVKFEKPLCIAYYQHLFGLGAHYNSLLYRDN
Protein: Integrator complex subunit 12 (Q9VBB3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. Required for the normal expression of the Integrator complex component IntS1. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:23288851, ECO:0000269|PubMed:39032490}.
Interaction partners:
- Integrator complex subunit 1
- Integrator complex subunit 5
- Integrator complex subunit 3
- Integrator complex subunit 4
- Integrator complex subunit 9
- Integrator complex subunit 6
- Integrator complex subunit 11
- Integrator complex subunit 10
- Integrator complex subunit 7
- Protein asunder
Sequence:
MAANIAAAAAAAQEVDPVLKKAIKLLHSSNPTSAAELRLLLDEALKARFGPEKSLTNNMTPRMLEDEANFSGRAATPPQQPINADEIINLTNSPDKEPSDSVDTIADSDDGLSAVGIVNTGDTGDFGDLNCCVCGEMVFTATNRLIECSKCGAMYHQECHKPPITKEEAADDQEQNWQCDTCCNKPTSSGRTTSSAAAVTPTVFIADEPMPLTSKAKSSVASSRSSNSSNSSSPFYRPEPSSSTNASSSSSSKHGHKSSSSSSSKSHKEERSSKSTAASSLSAIGGMEKHNSSGTSSRRSGSSTKSSSKSSSSKHHESGSSSKRRSKQ
Protein: Docking protein 3 (Downstream of tyrosine kinase 3) (Q7L591)
Organism: Homo sapiens (Human)
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Tyrosine-protein kinase CSK
- Growth factor receptor-bound protein 2
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
- TYRO protein tyrosine kinase-binding protein
Sequence:
MTRGARLRSDARAQLNQLSLDGGTGSGQKGKCEEFPSSLSSVSPGLEAAALLLAVTMDPLETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPGRRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFPGTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAFSTPCAPDLCRAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEPGPQSLPLLLGPEPNDLASGLYASVCKRASGPPGNEHLYENLCVLEASPTLHGGEPEPHEGPGSRSPTTSPIYHNGQDLSWPGPANDSTLEAQYRRLLELDQVEGTGRPDPQAGFKAKLVTLLSRERRKGPAPCDRP