wanglab/gogpt-training-data huggingface dataset:
Protein: M-zodatoxin-Lt8f (M-ZDTX-Lt8f) (Cytoinsectotoxin-1f) (CIT-1f) (P85258)
Organism: Lachesana tarabaevi (Spider)
Function: Insecticidal, cytolytic and antimicrobial peptide. Has insecticidal activity against the flesh fly S.carnaria. Has antibacterial activity against the Gram-negative bacteria E.coli. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis.
Subcellular location: Secreted {ECO:0000269|PubMed:18215128, ECO:0000269|PubMed:27287558}.
Interaction partners:
Sequence:
MKYFVVALALVAAFACIAESKPAESEHELAEVEEENELADLEDAVWLEHLADLSDLEEARGFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYLLKHYGKKALQKASEKL
Protein: DNA-directed RNA polymerase V subunit 7 (A6QRA1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase V involved in RNA-directed DNA methylation-dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerases II, IV and V subunit 9B
- DNA-directed RNA polymerases II, IV and V subunit 8B
- DNA-directed RNA polymerases II, IV and V subunit 11
- DNA-directed RNA polymerases IV and V subunit 3B
- DNA-directed RNA polymerases IV and V subunit 4
- DNA-directed RNA polymerases II, IV and V subunit 6A
- DNA-directed RNA polymerases II, IV and V subunit 10
- DNA-directed RNA polymerases II, IV and V subunit 3
- DNA-directed RNA polymerases II, IV and V subunit 9A
- DNA-directed RNA polymerases II and V subunit 8A
Sequence:
MFLKVQLPWNVMIPAENMDAKGLMLKRAILVELLEAFASKKATKELGYYVAVTTLDKIGEGKIREHTGEVLFPVMFSGMTFKIFKGEIIHGVVHKVLKHGVFMRCGPIENVYLSYTKMPDYKYIPGENPIFMNEKTSRIQVETTVRVVVIGIKWMEVEREFQALASLEGDYLGPLSEE
Protein: Large ribosomal subunit protein uL10z (60S acidic ribosomal protein P0-1) (O04204)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Interaction partners:
- Probable elongation factor 1-gamma 2
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL22y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein uL6z/uL6y
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL4z
Sequence:
MAVKATKAEKKIVYDSKLCQLLNEYSQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVRIHADKTGNQAFLSLLPLLQGNVGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPVELIKKGDKVGSSEAALLAKLGIRPFSYGLVVESVYDNGSVFNPEVLNLTEDDLVEKFAAGVSMITALSLAISYPTVAAAPHMFLNAYKNVLAVALATEYSFPQAENVKEFLKDPTKFAVAVAAPVSGESGGAVVAVAVEEEAAEESDGDMGFDLFG
Protein: Low-density lipoprotein receptor-related protein 11 (LRP-11) (Q8CB67)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MATRGGGPGPGFRHRALRGLLLLCLWLPGSRPGEPAAPSSGVDRLLQDFRRQLQRARPREELEPELLGGPREDCPGAGGTAVYRAVPDTIIRTQDSIAAGASFLRAPGSVRGWRQCVTACCSEPSCSVAVVQLPRGPSVPAPMPAPRCYLFNCTARGRSVCKFAPLRGYRTYTLSRAEDAAGIPPRPDEDKPPVSKAGKDVVLHLPTDGVVLDGRESSDDHAIVLYEWTLQQGDPSSVDMKVPQPGTLRLSRLKEGAYIFQLTVTDSVGQRSSDNVSVTVLPRPYSTGGCSSACSRYHFFCDSGCCIDIALACDGVRQCPDGSDEDFCQNLALDRKLVTHTVATSAQPGAMGLNEGEGDPKLEKSQRATTHNQPATVSHPETRIHSTQKAPESQINPVQPDSNSSGKNQEEGNYDLKSKSGQAGGEHPAPEAGAVLPLALGLAITVLLLLMVTCRLRLVKQKLKKARPITSEESDYLINGMYL
Protein: Leucine-rich repeat receptor-like kinase protein FLORAL ORGAN NUMBER1 (OsFON1) (EC 2.7.11.1) (CLV1-like LRR receptor kinase) (Q5Z9N5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Receptor-like kinase protein that regulates the size of the floral meristem.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Os03g0173500 protein
- protein-serine/threonine phosphatase
- protein-serine/threonine phosphatase
- Os12g0177900 protein
- aldehyde dehydrogenase
- Aldehyde dehydrogenase ALDH2b
- Aldehyde dehydrogenase
- Os12g0178000 protein
- Protein FLORAL ORGAN NUMBER2
- WUSCHEL-related homeobox 1
Sequence:
MPPTLLLLLLLLPPSLASPDRDIYALAKLKAALVPSPSATAPPPLADWDPAATSPAHCTFSGVTCDGRSRVVAINLTALPLHSGYLPPEIALLDSLANLTIAACCLPGHVPLELPTLPSLRHLNLSNNNLSGHFPVPDSGGGASPYFPSLELIDAYNNNLSGLLPPFSASHARLRYLHLGGNYFTGAIPDSYGDLAALEYLGLNGNTLSGHVPVSLSRLTRLREMYIGYYNQYDGGVPPEFGDLGALLRLDMSSCNLTGPVPPELGRLQRLDTLFLQWNRLSGEIPPQLGDLSSLASLDLSVNDLAGEIPPSLANLSNLKLLNLFRNHLRGSIPDFVAGFAQLEVLQLWDNNLTGNIPAGLGKNGRLKTLDLATNHLTGPIPADLCAGRRLEMLVLMENGLFGPIPDSLGDCKTLTRVRLAKNFLTGPVPAGLFNLPQANMVELTDNLLTGELPDVIGGDKIGMLLLGNNGIGGRIPPAIGNLPALQTLSLESNNFSGALPPEIGNLKNLSRLNVSGNALTGAIPDELIRCASLAAVDLSRNGFSGEIPESITSLKILCTLNVSRNRLTGELPPEMSNMTSLTTLDVSYNSLSGPVPMQGQFLVFNESSFVGNPGLCGGPVADACPPSMAGGGGGAGSQLRLRWDSKKMLVALVAAFAAVAVAFLGARKGCSAWRSAARRRSGAWKMTAFQKLEFSAEDVVECVKEDNIIGKGGAGIVYHGVTRGAELAIKRLVGRGGGEHDRGFSAEVTTLGRIRHRNIVRLLGFVSNRETNLLLYEYMPNGSLGEMLHGGKGGHLGWEARARVAAEAACGLCYLHHDCAPRIIHRDVKSNNILLDSAFEAHVADFGLAKFLGGATSECMSAIAGSYGYIAPEYAYTLRVDEKSDVYSFGVVLLELITGRRPVGGFGDGVDIVHWVRKVTAELPDNSDTAAVLAVADRRLTPEPVALMVNLYKVAMACVEEASTARPTMREVVHMLSNPNSAQPNSGDLLVTF
Protein: Mismatch repair protein MSH8, putative (Q38AW5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proliferating cell nuclear antigen
- DNA mismatch repair protein, putative
- Mismatch repair protein MLH1
- Mismatch repair protein PMS1, putative
- Exonuclease, putative
- Mismatch repair protein MSH3, putative
- DNA polymerase
- DNA polymerase epsilon catalytic subunit
- Flap endonuclease 1
- DNA polymerase
Sequence:
MPEVSLECEDICPENVSYPFLRGIDPKRPPSSITIPPRDLEAMAAMERQYWEVKSKHYDVVIFFKKGKFYELYDQDAAMAHREFGLKLVVDTTNRGKMRLAGVPEQTFSEWARLFVFRGYKVGRVEQMKEEGESSKNARPKVVPRELVEILTPGTITDPMMISGYGAVFVLALYPMGSGSVDGMAVDLSRRVVFHCPCGTNGKESAAGFVEEVLNEVSALLQQIRPREIIIPRGAVDAPGEEPKGSFGRRLFEWVEGEGFQVELVEEVGTSLRKLPLEERSLKEAGRFLAQYFRSLKLSNVDSILLEARPYNFHLLKQQVTSGVPSNDRSRCSDSTLLWYERREDPGLVLDAATVSNLELVGNLRDDSERGSLFNLINRCCTNGGKRLFRSWILRPSASPRVINARQEAVRFIIENNLNDLWAKTEESADVTTPICTPNSSTRTSEGPTQEFTQASGTQCGSKRGRTTNTFESRFTNLFATDFERNLSRLADLKGDSQQIAFVDPLVQYKKHLQLIISTVVAFEEMLDWSNNVQKECAPPLLQELWGTMGAVAPAVASIKACFDRKAAEVSGVIVPSQGACPAYDEATECLDIIEKKLDEVLGELRDNIFNGAAITYSHIGRENFLVEVPLMEAPKRCPPGFIERSRTSACVRYTVAGLEPLVEEHKRAKTKKADALLLVVRNIASHIFNYFPVLYEATAALCYFDCLLSLASLHTSGVATCYPVVQECDAGAYLLAEELRHPFLKSDSVPNTVNLDATHGRILVLTGPNMAGKSTLMRTVAVNVIIAQMGGPVFATSMRLAPVTRVFTRIGARDATHKGQSTLYVELSETAEIVRFAGPWSLCLVDELGRGTSTHDGYTIAHAMLAAMKKRHPVPPLLLFSTHYHALAQEEHKSMQKSTSSAASETGGVQLGYMDFAVSAASDSNIPTITFLYRLVPGICARSYGVEVALLAGISPGVVNTARVKSLELAKWYERQRDLGTVRGFITLSGTQFSHR
Protein: Glutathione S transferase E4 (EC 2.5.1.18) (A1ZB69)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- Glutathione S transferase O1
- Odorant receptor coreceptor
- Glutathione S transferase D11, isoform B
- Glutathione S transferase T2
- Glutathione S-transferase E14
- Microsomal glutathione S-transferase 1
- Glutathione S transferase D10, isoform A
Sequence:
MGKISLYGLDASPPTRACLLTLKALDLPFEFVFVNLFEKENFSEDFSKKNPQHTVPLLQDDDACIWDSHAIMAYLVEKYAPSDELYPKDLLQRAKVDQLMHFESGVIFESALRRLTRPVLFFGEPTLPRNQVDHILQVYDFVETFLDDHDFVAGDQLTIADFSIVSTITSIGVFLELDPAKYPKIAAWLERLKELPYYEEANGKGAAQFVELLRSKNFTIVS
Protein: Putative transport protein YbjL (P60869)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01015}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01015}.
Interaction partners:
- Inner membrane protein YbjM
- Uncharacterized protein YciO
Sequence:
MNINVAELLNGNYILLLFVVLALGLCLGKLRLGSIQLGNSIGVLVVSLLLGQQHFSINTDALNLGFMLFIFCVGVEAGPNFFSIFFRDGKNYLMLALVMVGSALVIALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHSGMESRQLSLALDNLSLGYALTYLIGLVSLIVGARYLPKLQHQDLQTSAQQIARERGLDTDANRKVYLPVIRAYRVGPELVAWTDGKNLRELGIYRQTGCYIERIRRNGILANPDGDAVLQMGDEIALVGYPDAHARLDPSFRNGKEVFDRDLLDMRIVTEEVVVKNHNAVGKRLAQLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKTIADRIGFISIHSQVTDLLAFCAFFVIGLMIGMITFQFSTFSFGMGNAAGLLFAGIMLGFMRANHPTFGYIPQGALSMVKEFGLMVFMAGVGLSAGSGINNGLGAIGGQMLIAGLIVSLVPVVICFLFGAYVLRMNRALLFGAMMGARTCAPAMEIISDTARSNIPALGYAGTYAIANVLLTLAGTIIVMVWPGLG
Protein: Msb1p (A0A1D8PD52)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Profilin
- Rga2p
Sequence:
MVNTKQLIANLELPKLPFNHEKQTTQKPTHNYLSNTTITDAGIMDPAQFTRKNLKSALHIITQELKKRGTKTPHIFLPFRSKVNDEKLESFLSSIAPSGELRTDNTLLQQLCSETDEFTLISALKYFWSRLPNNEIIGWDVYLEFKRREAEKGYPKNAFLSIMPKCLSSPAHASIVYDFLDLILSITSNSQFNYLSGRKISKMASFWAFSCRQQFLQSPFYDATQEEAEHNFIEGIDTWKKSTNALFHLVLAFLRSMLPETNSETLKIPKTLQSLLVTTQYPPSSDNESDQSMLRGAITIPCVCVSTTQPSKDAYELISKVRHNLKFDKKDDFLSIENYTILKNLFSKKGTFEIVNSLTDESKRILSRISSEPISSKFNISPGWNKSKVETDPDIPLFSEISIKDVSIHDYYIWTWLASISSDQPSVTKQIFGRSIVVEAEVLGFQKWIVVTEKTLSSEGYLQRFNLDRRMLSKHKRQISMEDYKNLPLPPIPVQETENGKINEESSNKNANEGRKHSNSVSSTSVFSNKKNDMGEFKQNQNVNSARSSAGTSTSNHSQEKATQSAPPYVTRASDIFDKSFSDQFSYIYPILNDTMETNEVDQQNTSSRELATSTSRFTKTTLGDMIAPAKNPVGRKAPPSFVSNSSILEAYTNTPNSQDSFLNHRQSGTPDNTFSPSKSDNNTIDTLKEDKYFEPFDLYHPEMDTSSQQGSVEPYDNYYVGIEAKTSATTAPQKLQPPAATHSQFSQPSQRLPNDISSLPSDSTIVYKDEKFNDDNTIAATPNNGSENINGENMGNELLEEQTKEEKEEELQRKIEEKKQKKKKEKKKLEKQAEAAQLAAAQAAGFPFALLPSNMPPPHIPGMPETPHEKKKNSSTSPKKKKQNSPKKNTSPKNKTPKKVKRIPCDPNKPLPQPTEVVEKQENSNLNSSSATDLESPVRVNDKKLVISSPPENDSIPLLAPPPSNNSIMSSPRMGFVSSPRIPPAQFSNPEAPSNDQLVTPKEQYNIFISQPPHGTETGVQSPKHPYFMQDERVHPTEEVPAPVQAPVPAPVPASASKPQIANIDTTPLPPANQHKPSVSNLEPRTPVEATSTHNSLQPKNQPQPQASVYNATPPMSHPPLHSLPRPNYYQQPSHNQHYFQPMPPHPQFVPRQQQPSYYQQQPLPYGSSPMPQQAPVPMQSYHPHAPPPQQMQYQQYFSQHPNSNPHPHPHPHQHLPPPLSHNGMMMMHSPQHAPMQSPSTMGPMNGGGANNAVMNMVPVGGRHNKNQTTNKANLRAAFVEGSFGI
Protein: Secreted protein 22 (Q9REZ7)
Organism: Bordetella bronchiseptica (Alcaligenes bronchisepticus)
Interaction partners:
Sequence:
MTIDLGVSLTSQAGGLQGIDLKSMDIQTLMVYVQGRRAELLTAQMQTQAEVVQKANERMAQLNEVLSALSRAKAEFPPNPKPGDTIPGWDNQKVSRIEVPLNDALRAAGLTGMFEARDGQVTAPGGRGTQVVNGTGVMAGSTTYKELESAYTTVKGMLDTASNTQQMDMIRLQAASNKRNEAFEVMTNTEKRRSDLNSSITNNMR
Protein: Serine/threonine-protein kinase TOR (EC 2.7.11.1) (Q38AC2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Rapamycin-insensitive companion of TOR2
- Uncharacterized protein
- Serine/threonine-protein kinase TOR
- non-specific serine/threonine protein kinase
- Protein artemis
- Ras-family member, GTP-binding protein, putative
- Small GTPase, putative
- Raptor N-terminal CASPase-like domain-containing protein
- Raptor N-terminal CASPase-like domain-containing protein
- Nuclear cap-binding protein subunit 2
Sequence:
MEGCAHPLTSQLQPIFSELHSGKLATLSSTISKLENVLKDQGDGFFQSNSECQSREANLRLSVWISSQIGQLFRRPETQRAAILCVKTLLDVEYEAINNLDQTFLRLLEDSVKCADMSVSRMAAEVWGLWLNNSGTSTEGIAQSRLKICFADLRESDKVMDKVAACLFLEELLKRTPSTVAPLLDVVAECLHPAVLSSSDLVQASAATALRYVLLLMYTSMNPSGIKKWYETFLSASLDALRSGAPERRTGAIRCFNAVMSSVTSNVSACDTAVTFSETSVAHVHEIWEYVSEQVTLTSTLELRRELLQSLTILALYDTEAFKRMSIAKVVEAASGVFQTPTEKDLEPLVFQTLGKLAGVMPDQIVTFLGCSMRHIEEVLKQGRHDACGLGAIACVAAFAEVNPRAVRPYLRQILAPILSGSLTVDFAKGVARICAAFPELRSTCLSKILEVAKKQLRDDRCNAGGAGALCDGGVSPAAQILSALSNLEFAGYPTLPFLCDTAVAYVSVPNGEVRRAAIKLCFKLVLSGCLGPQSPCRQTSDGVVIHSGCEHTQLFNKVIKKLVNAAVADPESDIRLDTLRNFTEEFDHTLALRDVVRSLFPALHDKHQNRLAVVRLLGRVSRRNPAHVYPMLRRIMVQCVTEMQYFEHAKKQEQAFSVLGAIIESAPGLGKPYISSLLNMCAARLSDGTREADVCAALLSCVGKLVRYAEGDDIRVCARIRPIVVQHILDSSHLPKKREALRALGDIVRTTKDVNVYEDHAELLPVLLQALHGGFKELWPVRKDVLQLMGIIGAVDPVRVKEILRGSRVNNNTKLVPFLPFEGEDTIAQTVVRSVLHILSLPSLTEDQSVAAVQVIVGIFSLEVLSPGCLVSFYGEVISSIQKQARVQVRKREEILVHLISLVRILKGHLRPHLKEITSTVDSFISATDLSVLRQVLALLKELCCSLREEFRPYMSSLLGPIIVLVEENVEETSEIVLDFFSAMGSLLEDHLHTVLPVVCNIIVDTSVPSRCRIVAVKTLICFTKRLPDLCFHASRCVHCLCRVLRESDGGDGVGDEGRLGFSAMEALCTLAGSLGKNFENFVLVVLPAVADRYGETSGEYCRFCHDIYEAIDGKRAPEVSSNGVGKAGGGGAPSLPFTAGTSASPLKDRADAYASLRFHLRKRDQASDEDWNHWLPQLAVNLLRSSSSPSHGRALTLAELHEPFARQMLHSAFAACYADMDEHTQREVVGLLTEVLRGLRVPSEVMQELLNLSEHMERQGIRLSAGGKASIKHSSNFCPFDRQVLMESSANCNLYSKALHYAEIEFFETVREYERSILRGCPKPLPVKDWQNLIKLCEKSIYFCNLLGQRESANGILKFIRQNLPLLTGKKVTELSQMMDAHLFDKLRWWSQSLQAYERRLQQEPNKVSNMVGLLRALDALGEYPRVLEMWRQFSKRVSKREVSKLASMGAHAAWLLRRWDDMEHITSFMSDEDYTGTTALFYKATLAARKKRFREAEKLIDMCRKRVDSKLSALVAESYDRAYDLFVGIQQLSELEELAMATSDPQSAMHWRQLWERRLSVMAYEGWPGTLANHTLLVPPSSEIDMWLRFVSLSRAHGQGSVSTEVLRELLGNQSIESAIENGIPTPAVAMGSFQHLYETNQRDSAIARLQLYVSKVEGSGAQHVSREREDMAVCHAKLAEWLVHQKKAHRTEDELQKIFHHLRRATELDKSNGSIWRTLARVHREAATKPADGSDSSGASGHIMEALSAYLRSVSLSEELEDALGFLSLWFMYGPLLAVQVGSTLKEEIEEVNPTVWLKVIPQIIARISSPNGTVADSVYNLLVLVARRHPQAILYSLNVAHSSYQGKGTADGVEPLKGSHRVLARIAEIHQNGKAMVEDSALVCRELVRCAVLWPELWINELGRALYQWERQRSAENLLLAMGPLLEQLKRPETMAEAQFAAELRQPLENACCHVERAVSSRHEQFMEEARRIFVSIERRIREQISGMSSLALQLVSPKLHQNGRNLSLVVPGQYREDGNYPLIASFQNVLKVLNSKQRPRRIYINGSNGEIYKFLLKGHEDLRLDERVMQLLGFVNTILEKHSVAKRHDCLIQTYSVTPLSDNAGLVGWVDHCDTLNKIIEDYRVNPRCIRMELDLMRSMCDNLYYLTAIQRVEPFEFALERTEGVDLVRSFWVKAPSAETWLERRTTYVCSLATMSMVGHILGLGDRHPSNLMIHAFSGRVVHIDFGDCFEVAQQRSIHPEKVPFRLTRMLVKAMEMGGIEGLFRHGCHTVMNVLREEGGSLLALLEAFVHDPLVSWWRDEAEGFSGNGQAASSVQTISVIGSMTNVAEEDSVGSLQLSQLSVQRRATTQQRVNANIEKDTSQTRKPKSVVKRIKRKLRGLEFPQSQEGKGSDGFTVEEQVSRLIEEATSNENLCVHFLGWCPFW
Protein: Protein wingless (Protein Wnt-1) (Protein int-1) (dInt-1) (dWnt-1) (P09615)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, and diffuses long distances despite its lipidation. Lipophorin is required for diffusion, probably by acting as vehicle for its movement, explaining how it can spread over long distances despite its lipidation. In non-neuronal cells, wls directs wg secretion via clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps26 and Vps35) to sustain a wls traffic loop encompassing the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi. In neuronal cells (the larval motorneuron NMJ), wg signal moves across the synapse through the release of wls-containing exosome-like vesicles.
Subcellular location: Secreted {ECO:0000269|PubMed:15166250, ECO:0000269|PubMed:18193037, ECO:0000269|PubMed:26974662, ECO:0000269|PubMed:8262072}. Synapse {ECO:0000269|PubMed:19837038}. Membrane; Lipid-anchor. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15166250}. Note=Palmitoleoylation converts wg into a membrane-anchored protein that is partitioned into specialized lipid raft microdomains before secretion (PubMed:15166250). In the wing imaginal disk epithelium, the protein is produced in the apical region of the cell and undergoes transcytosis to the basolateral surface to be released in the extracellular space (PubMed:26974662). Possibly associated with the extracellular matrix (PubMed:15166250). {ECO:0000269|PubMed:15166250, ECO:0000269|PubMed:26974662}.
Interaction partners:
- Frizzled-3
- Frizzled-2
- Frizzled
- Low-density lipoprotein receptor-related protein
- Palmitoleoyl-protein carboxylesterase NOTUM
- Protein hedgehog
- Protein wntless
- Segment polarity protein dishevelled
- Protein-serine O-palmitoleoyltransferase porcupine
- Dally-like, isoform A
Sequence:
MDISYIFVICLMALCSGGSSLSQVEGKQKSGRGRGSMWWGIAKVGEPNNITPIMYMDPAIHSTLRRKQRRLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTRNFSRGKNLFGKIVDRGCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSPQANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHNNEAGRAHVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVTNSLRATNALAPVSPNAAGSNSVGSNGLIIPQSGLVYGEEEERMLNDHMPDILLENSHPISKIHHPNMPSPNSLPQAGQRGGRNGRRQGRKHNRYHFQLNPHNPEHKPPGSKDLVYLEPSPSFCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL
Protein: 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) (P27815)
Organism: Homo sapiens (Human)
Function: Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes.
Subcellular location: [Isoform 1]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15738310}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15738310}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15738310}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:7888306}.; SUBCELLULAR LOCATION: [Isoform 4]: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:9677330}. Note=Isoform 4 has propensity for association with membranes. {ECO:0000269|PubMed:9677330}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm, cytosol. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:18095939}. Note=Predominantly cytosolic. {ECO:0000269|PubMed:18095939}.
Interaction partners:
- Disrupted in schizophrenia 1 protein
- A-kinase anchor protein 1, mitochondrial
- Alpha-aminoadipic semialdehyde dehydrogenase
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit gamma
- cAMP-dependent protein kinase catalytic subunit beta
- Beta-arrestin-1
- A-kinase anchor protein 6
- Beta-arrestin-2
- Adenosine kinase
Sequence:
MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Protein: Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20) (Q71MB6)
Organism: Rattus norvegicus (Rat)
Function: Mediates the transport of organic anions such as estrone 3-sulfate and thyroid hormones 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4). Capable of transporting pharmacological substances such as digoxin, ouabain, methotrexate and cAMP. Shows a pH-sensitive substrate specificity estrone 3-sulfate and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (By similarity). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity). May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells (By similarity). May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity).
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:14993604}; Multi-pass membrane protein {ECO:0000269|PubMed:14993604}. Apical cell membrane {ECO:0000269|PubMed:22768102}. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney. {ECO:0000269|PubMed:14993604}.
Interaction partners:
- Organic anion transporter 3
- Multidrug and toxin extrusion protein 1
- Solute carrier family 22 member 7
- Solute carrier family 22 member 4
- Organic cation/carnitine transporter 2
- Solute carrier family 22 member 2
- Solute carrier family 22 member 6
Sequence:
MQGSKGVENPAFVPSSPDTPRRASASPSQVEVSAVASRNQNGGSQPRESEDPQKSTEPSPPSSTLPASDEPPGSQLSELEEGPCGWRNFHPQCLQRCNNPKGFLLHYCLLALTQGIVVNGLVNISISTIEKRYEMKSSLTGLISSSYDISFCVLSLFVSFFGERGHKPRWLAFASFMIGLGALVFSLPHFFSGRYELGTIFEDTCLTRNSTRCASSTSLLSNYFYVFVLGQLLLGTGGTPLYTLGTAFIDDSVPTHKSSLYIGIGYSMSILGPAIGYVLGGQLLTMYIDVAMGQSSDLTEDDPRWLGAWWIGFLLAWLFAWSLIMPFSCFPKHLPGTAKIQAGKTSQTHQNNSTSFQHMDENFGKSIKDFPTAVKNLMRNTVFICLVLSTTSEALVTTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGVLVSKFKMKCKNTMKFALCTSGVALMLSFVFIYAKCENGPFAGVSESYNGTGEMGNLTAPCNANCNCLRSYYYPLCGSDGVQYFSPCFAGCLNSVSNRKPKAYYNCSCIERKVDITSTAXSPDFEARAGKCKTQCSNLPIFLGIFFITVIFTFMAGTPITVSILRCVNHRQRSLALGVQFMLLRLLGTIPGPIIFGVTIDSTCVLWDINECGTKGACWIYDNIRMAHMLVAISVTCKVITIFFNGLAIVLYKPPPPGTEVSFQSQNVVVSTITVEEDLNKIENEG
Protein: GH05248p (Q8MQS5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
GRGGSVDFDDPVIFVDPRETTEFVGISITEPVTTTTTTMATTTTTQPPRNCVVQRPRQSDQLIREGSSKRIYSLDDVECSELCSCGESLILTCHALCVPFAPCRTALAFYSHASPAYQAFRGRCLCYSGRFICMKPPLGEYILPGGIFLLLGYSAADEALLRPHTNLGVQDAVRALQQYVTTYIDNQTQCTLTLFNMTEENIIIAARLPHDGKLKDIELLRKEKDECTAILKTISHQINSEHSELQSHRLLSIFKMSEVEVVWPESTSAAARSGHGPGQFAGCDRLLYAAMLALAYLSSWTTLRMSDVAT
Protein: Transmembrane protein 79 (Mattrin) (Q9BSE2)
Organism: Homo sapiens (Human)
Function: Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity).
Subcellular location: Lysosome {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Colocalized with TGOLN2 in the trans-Golgi network. Colocalized with LAMP1 in the lysosome (By similarity). {ECO:0000250}.
Interaction partners:
- Surfactant protein C
Sequence:
MTEQETLALLEVKRSDSPEKSSPQALVPNGRQPEGEGGAESPGAESLRVGSSAGSPTAIEGAEDGLDSTVSEAATLPWGTGPQPSAPFPDPPGWRDIEPEPPESEPLTKLEELPEDDANLLPEKAARAFVPIDLQCIERQPQEDLIVRCEAGEGECRTFMPPRVTHPDPTERKWAEAVVRPPGCSCGGCGSCGDREWLRAVASVGAALILFPCLLYGAYAFLPFDVPRLPTMSSRLIYTLRCGVFATFPIVLGILVYGLSLLCFSALRPFGEPRREVEIHRRYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLFAVSRLIYWLTFAVGRSFRGFGYGLTFLPLLSMLMWNLYYMFVVEPERMLTATESRLDYPDHARSASDYRPRPWG