wanglab/gogpt-training-data huggingface dataset:
Protein: Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4) (Q80UG8)
Organism: Mus musculus (Mouse)
Function: Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26829768}. Cell projection, cilium {ECO:0000269|PubMed:17499049}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17499049}. Note=Located in cilia. In some cells, also found in basal bodies. {ECO:0000269|PubMed:17499049}.
Interaction partners:
- Cytosolic carboxypeptidase 6
- Tubulin--tyrosine ligase-like protein 12
Sequence:
MASAGTEHYSIGLRRGNSFKQRHPSGTVSASPSEKPSEVKVWSQAHQQVKPIWKLEKKHVGTLSAGLGTSFLGVPSQPAYFLCPSTLCSSGTTAVIAGHSNPCYLQSLPNLFSNTLLYRRTNVRQKPYQQLESFCLRSSPSEKRSFSLPQKGLPVSVTANKATSSTVFPMAQPMATSPTDPYLSLAAAGENPSRKSLASAISGKIASPLSYKPMLNNNSFMRPNSTKVPLSQATDGLKPVSSPKIQPVSWHHSGGTGDCVPQPGDHKVPQNIATVLDDVTAPITPSIPSTLNISTASVTSSQCSQSNFRMEAHPCGLDENPDSQSATKEVHFTEAVRKLAEKGLEKMPRQGYQFEQACFVNPSFQWGLLNRSRRWKPLMGQRFPQEDIGLDSAILPGTSDTLGLDSTVFCTKRISIHLLASHVHGLNPSPACGSAVDPQVLGEDRAPVPPSSLQPLGVAEVATRLSSVHLDQPGKEPEEAKDLNSCTKGGGSATDLQPNQVEPEDTEDELGDGLEDSCSHDENEEEEGDSECSSLSVVSPSESVALISRNCVDLMSKSLPNHEKVVRPALIYSLFPNVTPTIYFGTRDERVEKLPWEQRRLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPGFRSIREHQKLNHFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFPQSFILPQDSKLLRKAWESSSRQKWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKSLSNKFMHLTNYSVNKKNTEYQANADETACQGHKWALKALWNYLSQKGINSDAIWEKIKDVVVKTIISSEPYVTNLLKLYVRRPYSCHELFGFDIMLDENLKPWVLEVNISPSLHSNSPLDISIKGQMIRDLLNLAGFVLPNMEDIISSSSSPSSSSGSSTSLPSSPRDKCQMTPEHFTAQKMKKAYYLTQKIPDQDFYASVLDVLTPDDVRVLVEMEDEFSRRGQFERIFPSRISSRYLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLRNWCYKGFHTGIVSDSAPLWSLPTSLMTTSKGDGTPNSASKSRKKSASEGTTLSSEDRSTPKSKKSQAGLSPISRKTLSSRSNENTSKQSKRSTPGLPVLKYSGQSSRLSAASASQSVTDSRLTAVSS
Protein: Ribonuclease P protein component 2 (RNase P component 2) (EC 3.1.26.5) (Pop5) (P60780)
Organism: Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL)
Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00755, ECO:0000269|PubMed:20675586}.
Interaction partners:
- Ribonuclease P protein component 3
- Ribonuclease P protein component 4
- Ribonuclease P protein component 1
- Large ribosomal subunit protein eL8
- Selenocysteine-specific elongation factor
- RNA-free ribonuclease P
Sequence:
MLKTLPPTLREKKRYVALEIIYEMELSQKDVISVVRNALLNYSGVLGCSRTNPWLIDYGHPYGILRISREEVDTLRSSLSLMGEHKKKPINIRIIGISNSVKHIREKFLHVPHEPYYKVIQKLKRKGPKK
Protein: VPS39 subunit of HOPS complex (A0A8I6A3C4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
Sequence:
MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSFLLATVPWSHRILIGSAVSPQHTETGEEVLRMCVAVRKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDAKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIVAVLPRYVEIRTLEPRLLVQSIELQRPRPCIIVKPMPTYLLPPPDQTLSMWPEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPTLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKQKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSIWVLRDFPEDGLKIFTEDLPEVESLPRDRVLNFLIENFKALAIPYLEHIIHVWEETGTRFHNCLIQLYCEKVQNLMKDYLLSLPTGKSPVPAGEEAGELGESRQKLLTFLEISSSYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTKMAKEYCHKHYDQNKEGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPQANLQAALQVLELHYSKLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNSADT
Protein: Autophagy-related protein (Q582K6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Autophagocytosis associated protein, putative
- Cysteine protease
- Ubiquitin-like modifier-activating enzyme ATG7
- Autophagy-related protein
- Autophagy-related protein
- Cysteine protease
- non-specific serine/threonine protein kinase
- Protein kinase, putative
- Uncharacterized protein
- FUN14 family
Sequence:
MSKKDSKYKMSHTFESRQSDAAKVRERHPDRLPIICEKVYNSDIGELDRCKFLVPSDLTVGQFVSVLRKRVQLEAESALFVYTNDTVLPSSAQMADIYSKYKDEDGFLYMKYSGEATFGC
Protein: 5-aminolevulinate synthase, mitochondrial (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-ALA synthase) (Delta-aminolevulinate synthase) (O14092)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Delta-aminolevulinic acid dehydratase
- Putative glycine dehydrogenase
- Probable low-specificity L-threonine aldolase
- Uncharacterized aminotransferase C417.11c
- Probable serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- L-pipecolate oxidase
- D-amino-acid oxidase
- Porphobilinogen deaminase
- Ferrochelatase, mitochondrial
Sequence:
MERVVKLAAKHCPFVSKADPSALRRMAGAGLIRAGARCPVVRHALPVAAATGADVSRGFKSDSKQMAMEPSLDEIHLKAGVVNTGSRTCRHADAVKAAAEAATTTPVTKKHQMPKHYASDLNGVGPATTPRFDYDTFYREELDKKHRDKSYRYFNNINRLAKEYPLAHLADPNTRVEVWCSNDYLNMGGHKKIREAMHQCIETYGGGAGGTRNIAGHNQHAVRLEKSLADLHQKPAALVFGSCYVANDATLSTLGRKLPNCIFLSDEMNHASMINGIRNSRCEKIIFKHNDLVDLEAKLASLPLNRPKIIAFESVYSMSGNVAPISEICDLAKKYGAITFLDEVHAVGMYGPRGAGVAEETPGLLSRVDIITGTLAKSYGCVGGYIAASSTLVDMIRSLAPGFIFTTSLPPHVMVGALTAVEHLKVSNVEREQQRSAVRRVKQSLSEIGIPVLSNDTHIVPAMVGDAHLAKLASDSLLHDHNIYVQSINFPTVSVGTERLRITPTPAHNTEHYVQSLTNAMNDVWSKFNINRIDGWEKRGIDVGRLCKFPVLPFTTTH
Protein: Probable galactinol--sucrose galactosyltransferase 5 (EC 2.4.1.82) (Protein SEED IMBIBITION 1-LIKE) (Raffinose synthase 5) (Q9FND9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transglycosidase operating by a ping-pong reaction mechanism. Involved in the synthesis of raffinose, a major soluble carbohydrate in seeds, roots and tubers (By similarity).
Interaction partners:
- Alpha-galactosidase 2
- Alpha-galactosidase 1
- Alpha-galactosidase 3
- Galactinol synthase 2
- Galactinol synthase 3
- Galactinol synthase 1
- alpha-D-xyloside xylohydrolase
- Galactinol synthase 4
- Galactinol synthase 10
- Galactinol synthase 6
Sequence:
MASPCLTKSDSGINGVDFTEKFRLEDSTLLANGQVVLTDVPVNVTLTSSPYLVDKDGVPLDVSAGSFIGFNLDGEPKSHHVASIGKLKNIRFMSIFRFKVWWTTHWVGSNGRDIENETQIIILDQSGSDSGPGSGSGRPYVLLLPLLEGSFRSSFQSGEDDDVAVCVESGSTEVTGSEFRQIVYVHAGDDPFKLVKDAMKVIRVHMNTFKLLEEKSPPGIVDKFGWCTWDAFYLTVNPDGVHKGVKCLVDGGCPPGLVLIDDGWQSIGHDSDGIDVEGMNITVAGEQMPCRLLKFEENHKFKDYVSPKDQNDVGMKAFVRDLKDEFSTVDYIYVWHALCGYWGGLRPEAPALPPSTIIRPELSPGLKLTMEDLAVDKIIETGIGFASPDLAKEFYEGLHSHLQNAGIDGVKVDVIHILEMLCQKYGGRVDLAKAYFKALTSSVNKHFNGNGVIASMEHCNDFMFLGTEAISLGRVGDDFWCTDPSGDPNGTFWLQGCHMVHCAYNSLWMGNFIQPDWDMFQSTHPCAEFHAASRAISGGPIYISDCVGKHDFDLLKRLVLPNGSILRCEYYALPTRDRLFEDPLHDGKTMLKIWNLNKYTGVIGAFNCQGGGWCRETRRNQCFSECVNTLTATTSPKDVEWNSGSSPISIANVEEFALFLSQSKKLLLSGLNDDLELTLEPFKFELITVSPVVTIEGNSVRFAPIGLVNMLNTSGAIRSLVYNDESVEVGVFGAGEFRVYASKKPVSCLIDGEVVEFGYEDSMVMVQVPWSGPDGLSSIQYLF
Protein: Large ribosomal subunit protein uL4m (Q8VY61)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 50S ribosomal protein L33
- At1g64880
- Large ribosomal subunit protein uL3m
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Small ribosomal subunit protein uS14m
- Large ribosomal subunit protein bL21m
- At1g01640
- Large ribosomal subunit protein uL22c
- Small ribosomal subunit protein uS2m
- Large ribosomal subunit protein bL9c
Sequence:
MAASISRRIFRTFGSFSALGRSSSPNLSANTSGNGLASLTNDLKYGMALLSNRKLSTSILTPDDSFPSDLLTKKTVLTPDRTIGQYQDLVIPVTNFQNEEKGFMVLAGDVFDVPIRKDIIHNVVRWQLAKRQQGTHSTKTLSEVSGTGRKPWNQKGTGRARHGTLRGPQFRGGCVMHGPKPRSHAIKMNKQVRRLGLKIALTARAAEGKLLVFDDLGLPTHKTKNIVNYYNQMENTKKVLVVEGGPIDEKLKLATQNLHYVNIIPSIGLNVYSILLHDTLLMSRDAVNKIVERMHTPINR
Protein: Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3) (P31345)
Organism: Influenza A virus (strain A/Victoria/3/1975 H3N2)
Function: Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04062}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04062}. Host mitochondrion {ECO:0000255|HAMAP-Rule:MF_04062}.
Interaction partners:
Sequence:
MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMVPERNEQGQTLWSKMSDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKVYKTYFDKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDIDQSLIIAARNIVRRASVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAILRKATRRLVQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMVGVLPDMTPSTEMSMRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETHGTERLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKTTKRLTILGKDAGTLIEDPDESTSGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
Protein: TBC1 domain family, member 4 (D3Z881)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MESPSCIQDEPFPHPLEPEPIALAQPGATKPGDKRFRLWYVGGSCLDRRTTLPMLPWLMAEIRRRSLKPEAGGCGAPAAREVLLVLSAPFLRCVPAPGVGVGGGAGSGAVQPNTGVFIFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPNQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGRVIVTHKKAPSSLIDDCKDKFSLHEQQRLKLQGERGGDPGDGDEMGVLEAESPVSPDDGLPEKPDGLVNCPRALPSLASLPALASQPALASSRVCFPERILEDCGFDEQQEFRSRCSSVTGVMQKKVHENNQKTQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESLEPGLSQYICYVFQCANESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPISDQEENELVILHLRQLCEAKQKTHVHIGEGQAIISNSTIPENSTSGGRFKLDVLKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDFSPGGSPPGTPPASPLSSAWHTFPEEDSDSPQFRRRAHTFSHPPSSSRRKLNLQDGKAHGLRSPLLRQNSSEQCSDGEGRKRTSSTCSNESLSAGGTPVTPRRISWRQRIFLRVASPVNKSPSAMQQQKDGLDRTELLPLSPLSPTMEEEPLVIFLSGDEDTEKVEEKKKSKEIKSLWKKAIHQQILLLRMEKENQKLEARRDELQSRKVKLDYEEVGTCQKEVLIAWDKKLLNCRTKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKHQPPDTSYKELLKQLTAQQHAILVDLGRTFPTQPYFSVQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSSQEALVMECENFENIVEFLKSTLPDMNTTEMEKIITQVFEMDISKQLHAYEVEYHVLQDELLESSYACEDNESLEKLERANNQLKRQNMDLLEKLQVAHAKIQALESNLETLLTRETKMKALIRTLEQDKMAYQKTVEQIRKLLPADALANCELLLKDLSYPTNDKAKAGNKP
Protein: Runt-related transcription factor 2 (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Osteoblast-specific transcription factor 2) (OSF-2) (Q9Z2J9)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13950}. Cytoplasm {ECO:0000250|UniProtKB:Q08775}.
Interaction partners:
- Core-binding factor subunit beta
- Protein c-Fos
- Protein deacetylase HDAC6
- Osteocalcin
- Histone deacetylase 4
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- CCAAT/enhancer-binding protein beta
- Homeobox protein MSX-2
- Homeobox protein DLX-5
Sequence:
MLHSPHKQPQNHKCGANFLQEDSKEALVFKWLISAGHYQPPRPTESVSALSTVHAVIFKAASSIYNRGHKFYLEKKGGTMASNSLFSAVTPCQQSFFWNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRI
Protein: Interferon regulatory factor 5 (A0A8I5YBA0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDWGARSHSLSTQGTGNLAINLQSCALLSPTEPFAMNQSAPGIPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFYIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFQLYYDGPRDMPPQPYKIYEVCSNGPAPTESQPTDDYVLGEEEEEEDEEASLQLQRMLPGLSITEPVLPGPPIAPYSLPKEDTKWPPALQPPVGLGPPPPDPNLLAPPSGDSAGFRQLLPEVLEPGPLASNQPPTEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPQGCRLFYSQLEATQEQVELFGPVTLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCALAHGSCPNPIQREVKTKLFSLEQFLNELILFQKGQTNTPPPFEIFFCFGEEWPDLKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDHMVEQFKELHHIWQSQQRLQPMVQAPPVAGLDAGQGPWPMHPVGMQ
Protein: Heparin sulfate O-sulfotransferase (dmHS-2OST) (EC 2.8.2.-) (P25722)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8R3H7}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8R3H7}.
Interaction partners:
- Heparan-sulfate 6-O-sulfotransferase
- GH20068p
- Heparan sulfate 3-O sulfotransferase-B, isoform A
- LD41874p
- heparosan-N-sulfate-glucuronate 5-epimerase
- Extracellular sulfatase SULF-1 homolog
- Adenosine 3'-phospho 5'-phosphosulfate transporter 2
- SD01558p
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase
- Exostosin-2
Sequence:
MFRKLLKMWILLRPTHWLILIALCAVTCAGYWLLWSEIRLEHAFKPLSKLGDSLSPDQHASSTTDDFDFEEHLVVLYNRVPKTGSTSFVNIAYDLCKPNKFHVLHINVTANMHVLSLPNQIQFVRNVSRWHEMKPALYHGHMAFLDFSKFQIAHKPIYINLVRKPLDRLVSYYYFLRFGDNYRPNLVRKKAGNKITFDECVVQKQPDCDPKNMWLQIPFFCGHAAECWEPGSSWALDQAKRNLVNEYFLVGVTEQMYEFVDLLERSLPRIFHGFREHYHNSNKSHLRVTSSKLPPSESTIKSIQKTKIWQMENDLYDFALAQFEFNKKKLMQPDNKHVQKFMYEKIRPK
Protein: Canoe, isoform C (Q8IPP4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSHDKKMLDREAVRSVIQQWNANRLDLFALSEPDENLLFHGVMRFYFQDAGQKVATKCIRVASDATVTDVIDTLIEKFRPDMRMLSVPNYALYEVHANGEERRLNADEKPLLVQLNWHIDDREGRFLLKNIDQKTTPIEQTDLNFKRKLSKREKKEQKKKEKMAKLSSDPPTSNGSHLGLGNGVGASSGSAHMNGNAGGTGGDSSDAVAGKLYTELPETSFTRSISNPEAVMRRRRQQKLEKKLQQFRSRDGGPDTGGTLKIYGESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLEKADPLHYCLVQVNSDGTEYILDDDECPLSILMNHPTSRGSIMFHVRRRPADSQPRRRKKKPLGAANGANHISGDREGPVLVEVTHSGDGGRRIKLGSDPVEVGSANTNCLQLFGPSIQPRHCLISLLEGVCTVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLDSPTDGRYNLALSQSQLDSACLYERYRASTHYRPELQPTERAHKLTMFLHHVANLVYSVVQEQYTDPRILAFWMANSSEFLHFLKSDRHISAFSVQAQEVLAEAVQTAFRNLVNCFRLELSQTLNQFLSENIDHDSAAGLVLTVLGSAMALLRRCRVNAALTIQLFSQLFHYINVICFNTIVANSQMCTGDWGKVMTERLQLLELWAERQGLELAADCHLAKINQCAQFLQAPKSSVEEIQQLACSCFRLNSLQMAALLQQEKLPRNLVDTAIRMAESVADELTRADGREVRLEESPELHLALLLPDDGFSCDVVRGIPTGLVDFLNPLQQQGMCRLAAQPTSIGLWTVYMHQFNARSSSAMSNKLPQPELQLIKLHKNSNGMGLSIVAAKGAGQEKLGIYIKSVVPGGAADADGRLQAGDQLLRVDGQSLIGITQERAADYLVRTGPVVSLEVAKQGAIYHGLATLLQQPSPVIQRGNRRMSERDLTRMGGAESTKSLGPLIANNHPNHSLSLSQHLNNSHNNTLGNSNNSSIINPLAAHLPNSKSVPALHHHTGSGTISLANSKSRSTHSLHNNTSGMGGIGGAAAGGMLGQPNGSQNNANGNGNGNEQGFYQNLSVYRAQNQSQPILNERPPIAAHAAMNAYNGSSPLAPQQQPQQQQQSPYQQQQQQQHMQANANLPPTRPVSAYYHSQQSAQQQLQQQQQQQQQHSLQQQQFALSSGNLNGQQQQQQQHQHQHQLTLNNRTKSQQNFQHTLRMQQMMAPSMPNISNMYHHQQQQQQQLPLQQQQQQQQQPLMSSSQSMQNVNDFAGGYQNGSLEYRRSQLHDPSTLYEIQQQQLQQQQQQQQQQQQQQQASPNFIALPPKPLGSLQSPNKPNVPPSTAPKPQQDKPPLPPTATHPLFKATQQIAPGMNYVASTLDPPKGSYVASNQGNNRPLHSGSNPWEREEREKDLEMRREHIRQWREQQISELSQIVSRSPMQEEQLKTLILERDFERRAQELQEQEEQDQEQQYDKENVQELFRLAGGGQVSAIQTPITSYRQTEIKLAEMPDSNSLVDSVPPQPPAPTAQPLSSNTQQPKSILKHNRYSEGGVGPSGAPSSPSKSQKSASFADERHLHTEHPISNLAKELNQLTMLDKDNNNETLDAVVPPPPPPERNSSYLIMSQQKLRGSTGNATSSMGLLKTATSNQAAAAVEIKKASLLNTQTNNNNNLSGSLNNNTMHGSPLSAMELNAAYVSATGTGIIGGLGTPPPPPPLMQRDNKRVSFHDEENNFVSGNSQQQQLQQQYIMDNYGMEHQDLDTIREDTSYLQHNLDASMLPSMPATPDAALWNTSVQSTPGVIGAQEVYRDPRTRRLAEKQQQQQQQRAGDAVPEKLSFKEKMKMFALESGEDKTPKDKLKISRAQRDIDAVH
Protein: Neuroserpin (Peptidase inhibitor 12) (PI-12) (Serine protease inhibitor 17) (Serpin I1) (O35684)
Organism: Mus musculus (Mouse)
Function: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q90935}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000269|PubMed:17040209}. Perikaryon {ECO:0000269|PubMed:17040209}.
Interaction partners:
- Tissue-type plasminogen activator
- Plasminogen
Sequence:
MTYLELLALLALQSVVTGATFPDETITEWSVNMYNHLRGTGEDENILFSPLSIALAMGMMELGAQGSTRKEIRHSMGYEGLKGGEEFSFLRDFSNMASAEENQYVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANSINKWVENYTNSLLKDLVSPEDFDGVTNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLALSRQEVPLATLEPLLKAQLIEEWANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFLSKAVHKSCIEVNEEGSEAAAASGMIAISRMAVLYPQVIVDHPFLYLIRNRKSGIILFMGRVMNPETMNTSGHDFEEL
Protein: Kinesin, putative (Q57YB0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Kinesin, putative
- Kinesin, putative
- Kinesin-like protein
- Kinesin, putative
Sequence:
MTSQTSAVLVAVRVRPFNSREAPHECTVTVTDPRTITLTDVGQVNRFSTSVSGSMQRHVFTFDKIFWSVPGCVLPLPTTPSGHSQQMPSASSIRLSVADSSSTHSPSPTESPTVRRSSNSSDASVPCAAPTAEVSVSAITCVRPSFHRLPCFAQTPSCDNQTSVYSFIGPLMYDSVMTGYNSCLFAYGQTGSGKTYSMIGPHDSFSEKGDQRGIIQRLCEDLFDMMRREREEDEGISYNVECSFLEIYCERVRDLLTHTTFHSTNDDYSAPNVTTMGPPSNLRSKTSPSQSLVLTPRQGSSNPSPQLRIRQHPTHGPYVEGLSHVKVRDVEGVMHQLTCGMRERATAETRMNEHSSRSHALLQLNITRVSAVREEEAVVTRTRVCKVSLVDLAGSERISQSGATGDRFEEARNINLSLTTLTRVIMQLTDKQAGKNVVPSYRDSALTWLLSDSLGGNSKTIMLATVAPSAYCYQQTLNTLRFAGVAKTVINVATVNEDQRFQKLITSLREQIVKLTMQVEEGRILDPQNSEIRKLRRDKGELETQLEAMRIKVSKMVPATDLEILRRRVAETEEENTRLHAEKCNLQRQLMTTTTNLREELIRRRSEIVKLQEMLSKKDVEVQEWKRRHHSEVLRGGKATPQSTVQLSRGRAASGGRAASPSGAFKSNNSSKCGMLKTDVASISSDSIVEGDADSGCAAVGELQFRNQQLERRVEKLTESVKEEQKRREDVEKVNHNLRFELRELQKLRDATRGQLEEAQRRLTEKSHALEAAESDLASTRTLLSTERNGSCASEREALLTTQLEDLRVEYLGEKQSNVGLLMRVSHMEQQLFLSQQEAEIKSRDVGELEQMLLEETETSERYYIFQLYYSGKANICHAFHQKILLVKSLEPTNSVGVVTGVTRRSSFSDGPSVCVRALRDCECNEGCRRLLLVEEWFNTVLDLAAQRHAMWRWSASALSDEILSLRINFAEGEEKQQRLLRKLETAEISLEEAIAVRNSVQATLSTTVEQCEELKRQVEDLKEELQAQQQRNEMLITRIAEVQAVRDVFGEPSLSVDDPVSGLTLDGRGEEYQRFSRGSGERSLEDLSSEMTLYKERVDMLSAQLESERNRSHDLQVEMERELEIRQQEVQRVKSSCKASLFESTQIVREYEARLQELQDVIETLRTALAEESNNVDIAQEEVRQAKVRHCTLTTELHRVVEVKESLERRLEDTELQFSTIQQEQQKLKREFCEVERRLLDLSQMHEADVYLNVRCGGEDSEWLEKAAREKEAIEQQKRLVQKLNKELLEAITEQKASLLDMDRQIALMQRGATSHNGEANLTQESNGGVSQFQGCIDGEG
Protein: M-phase inducer phosphatase (EC 3.1.3.48) (Mitosis initiation protein) (P80) (P06652)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic and meiotic progression. Directly dephosphorylates cdc2 and stimulates its kinase activity (By similarity). Required for the G2/M transition of the cell cycle. Required for induction of meiosis II.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15629716}. Nucleus {ECO:0000269|PubMed:15629716}. Note=Accumulates in the nucleus in cycling cells; nuclear localization is the highest in G2. {ECO:0000269|PubMed:15629716}.
Interaction partners:
- Cyclin-dependent kinase 1
- Mitosis inhibitor protein kinase wee1
- G2/mitotic-specific cyclin cdc13
- Serine/threonine-protein kinase plo1
- Mitosis inducer protein kinase cdr1
- Serine/threonine-protein kinase cds1
- Serine/threonine-protein kinase chk1
- G2/mitotic-specific cyclin cig2
- Mitosis inhibitor protein kinase mik1
- Mitosis inducer protein kinase cdr2
Sequence:
MDSPLSSLSFTNTLSGKRNVLRPAARELKLMSDRNANQELDFFFPKSKHIASTLVDPFGKTCSTASPASSLAADMSMNMHIDESPALPTPRRTLFRSLSCTVETPLANKTIVSPLPESPSNDALTESYFFRQPASKYSITQDSPRVSSTIAYSFKPKASIALNTTKSEATRSSLSSSSFDSYLRPNVSRSRSSGNAPPFLRSRSSSSYSINKKKGTSGGQATRHLTYALSRTCSQSSNTTSLLESCLTDDTDDFELMSDHEDTFTMGKVADLPESSVELVEDAASIQRPNSDFGACNDNSLDDLFQASPIKPIDMLPKINKDIAFPSLKVRSPSPMAFAMQEDAEYDEQDTPVLRRTQSMFLNSTRLGLFKSQDLVCVTPKQSTKESERFISSHVEDLSLPCFAVKEDSLKRITQETLLGLLDGKFKDIFDKCIIIDCRFEYEYLGGHISTAVNLNTKQAIVDAFLSKPLTHRVALVFHCEHSAHRAPHLALHFRNTDRRMNSHRYPFLYYPEVYILHGGYKSFYENHKNRCDPINYVPMNDASHVMTCTKAMNNFKRNATFMRTKSYTFGQSVLASPDVNDSPTAMHSLSTLRRF
Protein: TraB (TraB protein) (VirB4 family type IV secretion/conjugal transfer ATPase) (Q0ZKR5)
Organism: Escherichia coli
Interaction partners:
Sequence:
MRAATATKPKKIDAYRKEPSVNKKYLPYSYHLNDYVISMENGDLMAFFKLDGRTHDCASDRELVTWHKDLNTLVKSFGTDHVELWTHEYHHEAKEYPDGEYDHFFPAYIDQYNRKLHGDSKQLINDLYLTVIYKQVGDKTQKFLAKFEKPTRDEIQQMQNEALEGLEDISEQILEAMKPYGIQQLGIYYRDKRGVEIPAPDKKEREELAEVDESDIFDEAIVIERNEPEPSQAHAYSKALEFLYFLANMEWAIVPVCRDRIREYIMDNRPVSSLWGDVVQIRTVDHNFYTTGIEFREYEEDTEPGQLNMLKEADFEYLLTQSFSCLSESSAKTFLTHQEKSLQETRDRAQSQLAQLGTALDMLTSREFVMGYHHGTVHVWDNDQNAVQRKARRVKVMLTGCGVVGGTLSLASEAAYYARLPGNQKWAPRPVPINSWNFLHFSPFHNFMRGKPDNNPWGPALTMFRTISGTPLYFNFHVTPLEELSYGKRPLGHALITGMSGEGKTTLLNFLLAQSMKYNPRLFVYDRDRGMEPFIRSVGGYYKVLQQGMPSGFAPLQIEPTKRNIALIKNLFRICVETTNNGPISATMATELAEGVDAVMGEGSLIPREARTVTILDGYVNEVVENGVSLKGLLREWTREGQYGWLFDNDKDSLDLSANDIFGFDLSEFIAAKEEVSSPARTPLMMYLLYRVRDSIDGKRRVIQCFDEFHAYLDDPVIEREVKRGIKTDRKKDAIYVFATQEPNDALSSRIGRTIMSQTVTKICLRDPEAIREDYAFLTDAEYDALMSITEHSRQFLVKQGQQSAIASFNLYPRNSDDIDADIKTMDNVLSVLSGEPQNAEIAHELVERLGNDPEVWLKEYWRLTA
Protein: NADH-cytochrome b5 reductase, putative (EC 1.6.2.2) (Q57Y81)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cytochrome b5, putative
- Cytochrome b5, putative
- Dihydroorotate dehydrogenase
Sequence:
MKALFASAVGAFASSWYNFSSVNCAASKSPFSHVDFRQYTLMNFYDESHDTRVFRFALPEADMSLNLEVLSFVELRHVGKDGSVLVRPFAPINSSNQRGYFEILVKNYQNSKVGNYLFSLKKGDAAEFKGPFVRVPIKSNRYKKIGILASDTGIAPVYQVARNVLRAPNNKTEISLIYENTRKEDVLLGNELNELMQTYPLFSPYFVLSKAPSDWMGGVGHITKEMVKALMPAPNRVGDSIILVSGPPPFLDSISGNKENGTSPAEQGDLKGVLSELGYIQKMVFKI
Protein: Uncharacterized ATP-dependent helicase C17A2.12 (EC 3.6.4.-) (O13762)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- General transcription and DNA repair factor IIH helicase subunit XPD
- Swi5-dependent recombination DNA repair protein 1
Sequence:
MDSLSAYPPQSTFQQLQNDEELARRLQDEWNSSSPSSAPSSSSSQNQVELDEQFARSLQNSQSSSYSLPPFDHPPSKNPTSSSLSTRKRWRQKRLWSFKNFPFRPPTRLTSTPSNSSSLPSIPSSSSTPSISSIPHTTSSVSNDIPSVLGSSDHPIDLDNPEHLTPPSSFITAKQLSRLPTPLPPPSSSSLPTGTISTNSFCPYERKVQPEHVTKELHQLLQHNTPSPFDTIDLQLKNEQVQSAGLLVSLLPHQVEGHAWMESMEQSSKCGGVMADDMGLGKTIQTIALLLTQKSQDPLRKTNLIVVSVALLHQWAEELSTKVHPSKKLSVYIHHGSTKKNLDSYELSQYDVVLTTYSMLAYEMKQNDAFNNNNPATATPPPACSLLETSWYRIVLDEAHTIRNRDTLAAKCCVKLDAKYRWCLSGTPIQNHIDEFYSLLKFLRIKPYCVWSLFAKDISRPLKSYRADIVEAALKRLRILLASTVFRRTKETRVNNLPIVNLPPKTIRTVSVNLLPEERALYNEQMSSAQSLVDNYFNNDHDLSRYGFLLVSLLRLRQFCCHPWLVKSSSLDNSFRIRDSENVRNACKSLDPLTIERIATLQDFNCSVCLDPCLAPVFIIPCGHFTCQECMSMLVGQKYGSSSTSTIIAKCPMCRGNIVQDSLVDATILQAIHGPLNSLKQLELDMNQSFSEQESIKLRWENRIDQMFTKKFGKRASEWKSSSKLNQARQTILDIIGSKRNEKILVYSQFSQYLCLVSHMLKLENIRHVRYDGTMSANQRQKSLHSFNNDKDVLVMLVSLKAGSVGLNLTIANHVILQEPFYNPSIEDQAIDRVHRLGQQKPVTVYRFITKDTIEERIVSVQRKKRQLVKEALDSNENNPLSRLDKEELLYLFGLNS