wanglab/gogpt-training-data huggingface dataset:
Protein: Chloride intracellular channel protein 6 (Glutaredoxin-like oxidoreductase CLIC6) (EC 1.8.-.-) (Parchorin) (Q96NY7)
Organism: Homo sapiens (Human)
Function: May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). {ECO:0000250}.
Interaction partners:
- Taperin
- Chloride intracellular channel protein 4
- Radixin
Sequence:
MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLAPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIHEKNLLKALRKLDNYLNSPLPDEIDAYSTEDVTVSGRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVAKRMK
Protein: Type III effector HopS1 (Q87WF4)
Organism: Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Interaction partners:
- Type III chaperone ShcS1
Sequence:
MKISGSTSPAHTSTNSAQKSSSKGLLSGLAKHFKGMLVSGNTSGHSALGHYASSSSGSKGKAPVRDDYSNGPQTRLNNTPLKRALARELDRFGYGSSATESFDRSLQRKDKNPELGKV
Protein: Ceramide synthase LAC1 (Very-long-chain ceramide synthase LAC1) (EC 2.3.1.297) (P28496)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ceramide synthase complex that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward hexacosanoyl-CoA (C26:0-CoA). N-acylates sphinganine and phytosphingosine bases to form dihydroceramides and phytoceramides, respectively. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10198056, ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:10198056, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ceramide synthase subunit LIP1
- Alkaline ceramidase YDC1
- Ceramide synthase LAG1
- Alkaline ceramidase YPC1
- Sphingolipid C4-hydroxylase SUR2
- 3-ketodihydrosphingosine reductase TSC10
- Sphingoid long chain base kinase 4
- Sphingoid long chain base kinase 5
- Dihydrosphingosine 1-phosphate phosphatase LCB3
- Dihydrosphingosine 1-phosphate phosphatase YSR3
Sequence:
MSTIKPSPSNNNLKVRSRPRRKSSIGKIDLGDTVPSLGTMFETKESKTAAKRRMQRLSEATKNDSDLVKKIWFSFREISYRHAWIAPLMILIAVYSAYFTSGNTTKTNVLHRFVAVSYQIGDTNAYGKGINDLCFVFYYMIFFTFLREFLMDVVIRPFAIRLHVTSKHRIKRIMEQMYAIFYTGVSGPFGIYCMYHSDLWFFNTKAMYRTYPDFTNPFLFKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIYITMDVSDFLLSFSKTLNYLDSGLAFFSFAIFVVAWIYLRHYINLKILWSVLTQFRTEGNYVLNFATQQYKCWISLPIVFVLIGALQLVNLYWLFLIFRVLYRILWRGILKDDRSDSESDEESDESSTTPTDSTPTKKDI
Protein: Protein HEAT-INDUCED TAS1 TARGET 4 (Q9SU75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates both basal and acquired thermotolerance.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8LFW5}. Nucleus {ECO:0000250|UniProtKB:Q8LFW5}.
Interaction partners:
- Pentatricopeptide repeat-containing protein At2g29760, chloroplastic
- Peptidyl-prolyl cis-trans isomerase FKBP13, chloroplastic
Sequence:
MAERLLQSMSRVAGRCHPDCVKASDEQEDYHASQNAALVAVNLISSARLILKLDAEFTEYSAQFLMDNAGKEDDPGEVDQQRNQVTTENCLRYLAENVWTKKENGQGGMDQQRPVLTVKDCLELAFKKGLPRREHWAHLGCTFKAPPFACQIPRVPVKGEVVEVKTFDEAFKLLVHQPIGAKLHLFSPQIDNVGEGVYKGLTTGNETHYVGLRDVLIASVEEFEGDSVAIVKICYKKKLSFIKVSLSVRFLSVAHDGDKSKFIAPTGLLVDFCVPRLSIN
Protein: Variant surface glycoprotein (VSG)-related, putative (Q57YT4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MCGIKYCVVLFALVLRTSISGEGKIVNEDEFGALCGMINFAKGALQRVEEAQEVNKSLTKIGSRCLELAGDVKLNNTCIDNNDESCEYSKVFWDAAKLSMSEGNAGKESLDDEKLEKVKQVASAAETIYGNMTKRHWVLNGDIIKQMLNRALYGIPHQPKKMRERSATRKRVCEEDVSQPEVNQGPVSLSRDLLCLCATDRKSRRKTKLCCENCVSGENRRVWRPRNDAQKRWNFLVSQCSNVEGHKEGFAKLVEKFRRSLNHRVDGCSGTMYVLGKHKKQLFWPLEFLSGYVPGPGVHYIINTRAGMVEDIPWLGELREIATLMGDSSEDNVEGRELKSAIEKLEGDLEELFPTGGVRRG
Protein: Ammonium transporter MEP2 (P41948)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transporter for ammonium (both charged and uncharged NH3 and NH4) to use as a nitrogen source. The affinity of MEP2 is about twenty times higher than that of MEP1. MEP3 has the lowest affinity. Under ammonium limitation acts as an ammonium sensor, generating a signal that leads to pseudohyphal (filamentous) growth.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11069679, ECO:0000269|PubMed:16477434, ECO:0000269|PubMed:18434596, ECO:0000269|PubMed:24476960, ECO:0000269|PubMed:27088325}; Multi-pass membrane protein {ECO:0000269|PubMed:27088325}.
Interaction partners:
- Ammonium transporter MEP1
- Ammonium transporter MEP3
- General amino-acid permease GAP1
- Allantoate permease
- Glutamine synthetase
- Urea amidolyase
- Nitrogen regulatory protein GLN3
- Nitrogen regulatory protein DAL80
- Nitrogen permease reactivator protein
- Urea active transporter
Sequence:
MSYNFTGTPTGEGTGGNSLTTDLNTQFDLANMGWIGVASAGVWIMVPGIGLLYSGLSRKKHALSLLWASMMASAVCIFQWFFWGYSLAFSHNTRGNGFIGTLEFFGFRNVLGAPSSVSSLPDILFAVYQGMFAAVTGALMLGGACERARLFPMMVFLFLWMTIVYCPIACWVWNAEGWLVKLGSLDYAGGLCVHLTSGHGGLVYALILGKRNDPVTRKGMPKYKPHSVTSVVLGTVFLWFGWMFFNGGSAGNATIRAWYSIMSTNLAAACGGLTWMVIDYFRCGRKWTTVGLCSGIIAGLVGITPAAGFVPIWSAVVIGVVTGAGCNLAVDLKSLLRIDDGLDCYSIHGVGGCIGSVLTGIFAADYVNATAGSYISPIDGGWINHHYKQVGYQLAGICAALAWTVTVTSILLLTMNAIPFLKLRLSADEEELGTDAAQIGEFTYEESTAYIPEPIRSKTSAQMPPPHENIDDKIVGNTDAEKNSTPSDASSTKNTDHIV
Protein: Zgc:175135 (E7F299)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPWPKGILLFVMAVMSFSSSIAGPKAFSDSSANGAVSGDAIHIGRLSIGGQSVEPDNQKDKSRPASAEQTIEDERFRLARAKLQRLGPSLQCGNDSMTLNIKGHRTPHFLVERGEGSPVSLSEMPASCGFSLKRARRDVSLVAPYTGCNVRQQGGSYVLPLIIMGAPVQMSCPVSPRLPVVSCTSSGMIVSFGVRGDDVLVKVSGSWMPLSLTSSMCSFTLDNVGGSVVLTAPFTGSCWDSQDTDWNLTLLLGDREVVLSCPKATDTPTVPPTPFPQGYPYFPFGYPWWYPWNQAPPAAPPTTPAPVKAPVYNPFPMYYPYYYGGFPHRRHHHRHHHRHWYPESQESWFPMLPPYEFAPLQPLPPPTPAAPQVQQYPVFPMPFNPVNTGFKNPFWPPVPQSVSNPQSLNSPWNIWARKQKR
Protein: C-type lectin domain family 18 member A (Mannose receptor-like protein 2) (A5D8T8)
Organism: Homo sapiens (Human)
Function: Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.
Subcellular location: Secreted {ECO:0000269|PubMed:26170455}. Endoplasmic reticulum {ECO:0000305|PubMed:26170455}. Golgi apparatus {ECO:0000305|PubMed:26170455}. Endosome {ECO:0000305|PubMed:26170455}.
Interaction partners:
Sequence:
MLHPETSPGRGHLLAVLLALLGTAWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGTPTPSLASGLWRTLQVGWNMQLLPAGLVSFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQAAIEAFVCAYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS
Protein: Zinc finger protein 540 (K7EK80)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAHALVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCVVARDVTGRQCPGLLSRHKTKKLSSEKDIHEISLSKESIIEKSKTLRLKGSIFRNEWQNKSEFEGQQGLKERSISQKKIVSKKMSTDRKRPSFTLNQRIHNSEKSCDSHLVQHGKIDSDVKHDCKECGSTFNNVYQLTLHQKIHTGEKSCKCEKCGKVFSHSYQLTLHQRFHTGEKPYECQECGKTFTLYPQLNRHQKIHTGKKPYMCKKCDKGFFSRLELTQHKRIHTGKKSYECKECGKVFQLIFYFKEHERIHTGKKPYECKECGKAFSVCGQLTRHQKIHTGVKPYECKECGKTFRLSFYLTEHRRTHAGKKPYECKECGKSFNVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLRVHSRIHTGEKPYECKECGKAFMLRSVLTEHQRLHTGVKPYECKECGKTFRVRSQISLHKKIHTDVKPYKCVRCGKTFRFGFYLTEHQRIHTGEKPYKCKECGKAFIRRGNLKEHLKIHSGLKPYD
Protein: Capsid protein (Beta-A protein) (Coat protein) (P04866)
Organism: Barley stripe mosaic virus (BSMV)
Function: Capsid protein self-assembles to form rod-shaped virions about 21,6 nm in diameter for the narrow nes and 22,4 for the wide ones, and 110-150 nm in length depending on the size of the encapsidated RNA. They display a helical symmetry of 23.2 subunits per turn of the viral helix and with a central canal enclosing the viral genomic RNA.
Subcellular location: Virion {ECO:0000269|PubMed:23725818, ECO:0000269|PubMed:26278173}.
Interaction partners:
Sequence:
MPNVSLTAKGGGHYIEDQWDTQVVEAGVFDDWWVHVEAWNKFLDNLRGINFSVASSRSQVAEYLAALDRDLPADVDRRFAGARGQIGSPNYLPAPKFFRLDKRTIAELTRLSRLTDQPHNNRDIELNRAKRATTNPSPPAQAPSENLTLRDVQPLKDSALHYQYVLIDLQSARLPVYTRKTFERELALEWIIPDAEEA
Protein: T-DNA border endonuclease VirD1 (EC 3.1.-.-) (P18591)
Organism: Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Function: Tumor formation by A.tumefaciens involves the transfer and integration of a defined segment (T-DNA) of Ti plasmid DNA into the plant nuclear genome. The virD operon encodes a site-specific endonuclease that cleaves at a unique site within both 24 bp direct repeats flanking the T-DNA.
Interaction partners:
Sequence:
MSQGSRPTSSDIAVNQRECVKVEGFKVVSTRLRSAEYESFSHQARLLGLSDSMAIRVAVRRIGGFLEIDAETRHRMEAILQSIGTLSSNIAALLSAYAENPTMDLEALRAERIAFGKSFADLDGLLRSILSVSRRRIDGCSLLKDAL
Protein: Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-) (Modulator of drug activity A) (P17117)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major oxygen-insensitive nitroreductase in E.coli.
Interaction partners:
- Oxygen-insensitive NAD
- Uncharacterized protein YbjC
- N-ethylmaleimide reductase
- Quinone reductase
- Ribosomal protein bS6--L-glutamate ligase
- NADPH:quinone oxidoreductase MdaB
- FMN-dependent NADH:quinone oxidoreductase
- Uncharacterized NAD
- Thymidine kinase
- Uncharacterized protein YbjN
Sequence:
MTPTIELICGHRSIRHFTDEPISEAQREAIINSARATSSSSFLQCSSIIRITDKALREELVTLTGGQKHVAQAAEFWVFCADFNRHLQICPDAQLGLAEQLLLGVVDTAMMAQNALIAAESLGLGGVYIGGLRNNIEAVTKLLKLPQHVLPLFGLCLGWPADNPDLKPRLPASILVHENSYQPLDKGALAQYDEQLAEYYLTRGSNNRRDTWSDHIRRTIIKESRPFILDYLHKQGWATR
Protein: Monomethylamine methyltransferase MtmB3 (MMA methyltransferase 3) (MMAMT 3) (EC 2.1.1.248) (P0C0W4)
Organism: Methanosarcina barkeri (strain Fusaro / DSM 804)
Function: Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC.
Interaction partners:
Sequence:
MTFRKSFDCYDFYDRAKVGEKCTLDDWDLMRIPMKAMELKQKYGLDFKGEFIPTDKDMMEKLFKAGFEMLLECGIYCTDTHRIVKYTEDEIWDAINNAQKEFVLGTGRDAVNVRKRSVGDKAKPIVQGGPTGSPISEDVFMPVHMSYALEKEVDTIVNGVMTTVRGKAPVPKSPYEVLAAKTETRLIKNACAMAGRPGMGVOGPETSLSAQGNISADCAGGMTCTDSHEVSQLCELKIDLDAISVIAHYNGNSDIIMDEQMPIFGGYAGGIEETTIVNIATHINSLVMSNASWHLDGPVHIRWGSTNTRETLTIAGWACATISEFTDILSGNQYYPCAGPCTEMCLLEASAQSITDTASGREILSGVASAKGVVTDKTTGMEARMMGEVARATAGVEISEVNVILDKLVALYEKNYASAPAGKTFQECYDVKTVTPTEEYMQVYDGARKKLEDLGLVF
Protein: Tlg2p-like protein a (AtTLG2a) (Syntaxin-41) (AtSYP41) (O65359)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Contributes to the regulation of secretory and vacuolar transport pathways in the post-Golgi network, and to the maintenance of the Golgi apparatus and trans-Golgi network (TGN) morphologies. Together with VTI12, required for membrane fusion. Vesicle trafficking protein that functions in the secretory pathway and mediates liposome fusion; the fusion of phospholipid vesicles containing SYP41 and VTI12 is triggered by YKT61 and YKT62. Required for extracellular resistance responses to a fungal pathogen. Also involved in the protection of chloroplasts from salicylic acid-dependent biotic stress.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10888666, ECO:0000269|PubMed:11739776, ECO:0000269|PubMed:15342965, ECO:0000269|PubMed:15743878, ECO:0000269|PubMed:22307646}; Single-pass type IV membrane protein {ECO:0000255}. Note=SYP41 is found in a different region of the TGN than SYP42. {ECO:0000269|PubMed:11739776}.
Interaction partners:
- Vesicle transport v-SNARE 12
- Syntaxin-61
- Vacuolar protein sorting-associated protein 45 homolog
- VAMP-like protein YKT62
- VAMP-like protein YKT61
- Vesicle transport v-SNARE 11
- Syntaxin-51
- Vesicle transport v-SNARE 13
- Syntaxin-121
- Syntaxin-52
Sequence:
MATRNRTLLFRKYRNSLRSVRAPLSSSSLTGTRSGGVGPVIEMASTSLLNPNRSYAPISTEDPGTSSKGAITVGLPPAWVDVSEEISVNIQRARTKMAELGKAHAKALMPSFGDGKEDQHNIESLTQEITFLLKKSEKQLQRLSASGPSEDSNVRKNVQRSLATDLQLLSMELRKKQSTYLKRLRQQKEDGMDLEMNLSRNRYRPEEDDFGDMLNEHQMSKIKKSEEVSVEREKEIQQVVESVNDLAQIMKDLSALVIDQGTIVDRIDYNIENVATTVEDGLKQLQKAERTQRHGGMVKCASVLVILCFIMLLLLILKEIFL
Protein: Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Q99JP0)
Organism: Mus musculus (Mouse)
Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity).
Interaction partners:
- Mitogen-activated protein kinase kinase kinase 1
Sequence:
MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKLKWSNSFHHFVKMALTKNPKKRPNAEKLLQHPFVTQPLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIPSTSRNVREEKTRSEINFGQVKFDPPLRKETEPHHELPDSDGFFDSSEEIYYTARSNLDLQLEYGQGHQSHCFLGGNKSLLKSVEEELHQRGHVAHLEDDEGDDDDSKHSTMKAKVPPPLPPKPKSIFIPQDTHSAEDGNQGTIKRCPSSGSPAKPSHVPPRPPPPRLPPQKPAVLGNGVNSFQLNGERDGSLYQQQSEQRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCATSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSVSGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFAVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIEFPMPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDAPQTSVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDNTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY
Protein: Glutamyl-tRNA(Gln) amidotransferase subunit E (Glu-ADT subunit E) (EC 6.3.5.-) (Q9V0U0)
Organism: Pyrococcus abyssi (strain GE5 / Orsay)
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
Interaction partners:
- Glutamyl-tRNA
- L-asparaginase
- Glutamate--tRNA ligase
- Uncharacterized protein
- Archaeal Rqc2 homolog aRqcH
Sequence:
MMVMTDKFNYEELGLKVGLEIHRQLDTKKLFSPVPSELSDKVEFTFQRRLRPTMSELGEIDPAALEEFKKGRVYVYEGNYELTDLVYMDEEPPRGPDREALEVALQIAYLLNAKPVDEVYYMRKIVIDGSNVSGFQRTAIIATDGKVETPWGAVGIPTICLEEDAARIIERKDKEVIYRLDRLGIPLIEISTTPDIHHPEQAKVVAKFIGDALRATKKVKRGLGTIRQDLNVSIKGGARIEIKGVQELDMIPIIIEREVERQLNLLKIRDELRKRGVKPKDIKEEFYDVTDIFENTKSKIIARVIKKGGKVLAIKLPKFRGLIGREIQPGRRLGTEFADRAKKYVPGIFHIDELPNYGISQEEVNKVIERLNLSEEDAFVLVAAEEEKAKNALREVIKRAREAIEGVPEETRRALPDGNTEYMRPLPGKARMYPETDIPPLRIPDDLKKKIKENLPELPQAKVERYVKEYKLDRSLAQTLVDDERDELFEELVSMGVKPSLAASILVVVLKGLRKEVPIENVTDEHIREAFQLYLEGKIAKEAFEEIFKELARNPSKSAREVAEEKGLTLLSEEEVTRIIEEVIQQNIEVVKAKGMGAMGLIMGRVMAKVRGKADGKLVSQIVRRKLQEISGG
Protein: Integrin subunit alpha 3 (D3ZQM3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Interaction partners:
- Integrin beta-1
- Integrin beta-3
- Integrin beta-4
- Focal adhesion kinase 1
- Integrin subunit alpha 5
- Integrin beta-6
- CD151 antigen
- Integrin alpha-6
- Paxillin
- Thrombospondin-2
Sequence:
MGPGPRRVPRDPGWMLRALALMVAASGRVAFAFNLDTKFLVVKEAVNPGSLFGYSVALHRQTERQQRYLLLAGAPRDLAVDDDYTNRTGAVYLCPLTALKNDCERMDISEKSDPDHHIIEDMWLGVTVASQGPAGRVLVCAHRYTKVLWSGLEDQRRMVGKCYVRGNDLQLDPGDDWQTYHNEMCNSNTDYLQTGMCQLGTSGGFTQNTVYFGAPGAYNWKGNSYMIQRKDWDLSEYSYRGSEDQGNLYIGYTMQVGSAILHPSEITLVTGAPRHQHMGAVFLLKQESGGDLQRRQVLKGTQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAVYVFMNQAGTSFPDQPSLLLHGPSRSAFGISVASIGDINQDGFQDIAVGAPFEGLGKVYIYHSSSGGLLKQPQQIIHGETLGLPGLATFGYSLSGKMDVDENLYPDLLVGSLRPGRVMARPVINILHRTLVARPAVLDPSLCTVTSCVQVELCFAYNQSAGNPNYRRNITLAYTVEADRDRRPPRLRFARSQSSVFHGFFSMPETHCQTLELLLMDNVRDKLRPIVITMNYSLPLRMPDRLKLGLRSLDAYPVLNQAQAMENHTEVHFQKECGPDNKCDSNLQMRAAFVSEQLQPLSRLQYSRDTKKLFLSINVTNSPSRQRAGEDAHEALLTLEVSSALLLSSVRPAGTCQANETNTVCELGNPFKRNQRMELLIAFEVTGVTLHTRDLRAHLQLSTSSHQDNLQPMFLTLQVDYTLQASLSLMNHRLQSFFSGTVMGEAAMKTVKDVGSPLKYEFQVSPVGDGLAALGTLVLGLEWPYEVTNGKWLLYPTEITIHSNGSWPCQPVSSLATLVVFRNLTIPFKPLSPQRRRRQLDPGGDQGPPPVTLAAAKKAKSETVLTCSNGRARCVWLECPLPDASNITNVTVKARVWNSTFIEDYKDFDRVRVDGWATLFLRTSIPTINMENKTTWFSVDIDSELVEELPAEIELWLVLVAVDLRGVCVCVCVCVCVCACTHASSPVRIREEDRYPPPGSTLPTKKHWVTSWQIRDRYY
Protein: Tripartite motif-containing protein 29 (Q8R2Q0)
Organism: Mus musculus (Mouse)
Function: Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14134}. Lysosome {ECO:0000250|UniProtKB:Q14134}. Note=Colocalizes with intermediate filaments. {ECO:0000250|UniProtKB:Q14134}.
Interaction partners:
- Keratin, type II cytoskeletal 5
Sequence:
MEGADACRSNGASPEARDTRSPPGPSGSLENGTKADSKDTKTTNGHSGEVTEGKTLGSALKSGEGKSGLFSSNEWRRPIIQFVESVDDKGSSYFSMDSAEGRRSPYAGLQLGASKKPPVTFAEKGELRKSIFSEPRKPTVTIVEPGEVRRNSYPRADSSLLARAKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDDVEKWQKEKDRIKSFTTNEKAILEQNFRDLVRELEKQKEEVRAALEQREQDAVDQVKVIVDALDERAKVLHEDKQTREQLHNISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLGQSLGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYMNSYTSSYGNEWSTPDTMKRYSMYLTPKGGGRTSYQPSSPSRLSKETNQKNFNNLYGTKGNYTSRVWEYTSTVQNSEDMPTVQGNSSFSLKGFPSLLRSQVPKAQPQTWKSGKQTLLSHYRPFYVNKGSGIGSNEAP
Protein: Spindle pole component BBP1 (BFR1-binding protein 1) (Q12365)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:10654940, ECO:0000269|PubMed:14767068}. Note=Associates with the periphary of the central plaque.
Interaction partners:
- Monopolar spindle protein 2
- Spindle pole component 29
- NAP1-binding protein
- Spindle pole body component SPC42
- Protein SFI1
- Chaotic nuclear migration protein 67
- Cell division control protein KAR1
- Spindle pole body assembly component MPS3
- Spindle pole body component 110
- Cell division control protein 31
Sequence:
MNQEDNTGGGGIFGLFKWTKDALFGTDISPSMKYKDQEERRDRSRYAQDDTNFSMKFGNDSNRRSTNLSRSNSWSGLDSTLHRKYELLPEYNENGFNSIVNGDHHSKERIRSLRSPAPIVPREPLRNEPTDTFGHRLHTKRRTINELSNSQIPFIPPQEDDPLLSKLFNKDGVNEVRRSPYKLSVKDIPGKFPSPLTKRDEIDNYYVRDEDACHKNREYKKAYFDLFAQMDLNSRDLEDLCEDVREQREQFHRNEQTYKQAYEEMRAELVNELKKSKTLFENYYSLGQKYKSLKKVLDQTISHEAELATSRERLYQEEDLKNFEIQTLKQRLSDLELKYTNLQIEKDMQRDNYESEIHDLLLQLSLRNNERKDTSAGSNIFSTGQ
Protein: Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (Q96GP6)
Organism: Homo sapiens (Human)
Function: Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEGAGPRGAGPARRRGAGGPPSPLLPSLLLLLLLWMLPDTVAPQELNPRGRNVCRAPGSQVPTCCAGWRQQGDECGIAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEPGWWGAQCASACYCSATSRCDPQTGACLCHAGWWGRSCNNQCACNSSPCEQQSGRCQCRERTFGARCDRYCQCFRGRCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCDPVTGACHLETNQRKGVMGAGALLVLLVCLLLSLLGCCCACRGKDPTRRPRPRRELSLGRKKAPHRLCGRFSRISMKLPRIPLRRQKLPKVVVAHHDLDNTLNCSFLEPPSGLEQPSPSWSSRASFSSFDTTDEGPVYCVPHEEAPAESRDPEVPTVPAEAPAPSPVPLTTPASAEEAIPLPASSDSERSASSVEGPGGALYARVARREARPARARGEIGGLSLSPSPERRKPPPPDPATKPKVSWIHGKHSAAAAGRAPSPPPPGSEAAPSPSKRKRTPSDKSAHTVEHGSPRTRDPTPRPPGLPEEATALAAPSPPRARARGRGPGLLEPTDAGGPPRSAPEAASMLAAELRGKTRSLGRAEVALGAQGPREKPAPPQKAKRSVPPASPARAPPATETPGPEKAATDLPAPETPRKKTPIQKPPRKKSREAAGELGRAGAPTL
Protein: Pentatricopeptide repeat protein (AFU_orthologue AFUA_2G12010) (C8V1T9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- U6 snRNA-associated Sm-like protein LSm4
Sequence:
MKALPTNELEDLLTRRSNTRVRLANAMQPLYVLLRDRRIRPNTRHYKAVIQSNSDPEHGSSKTVRKLLVEMEKYNIPVDAGPLRAALLALAVHPDYLLRQDVLRALRDRWVTLSEDDWHYVVAGLIREQQFELALDHIAHMERKRIVVKDWLHSLLIYNLCDFNEFDLVRELMVVRLNQGHVMSRELRTYVLDSASKAHHYDLTSFIWRRIVELKNAAPPRGICEQVLEVAARHGDTQLKNAVVNMLEHNELELGYKDFLSLVRGHLAAGDLYSALEICTGTARGARMRCFKSIRVHCRENNIHPRDIWNTIKALKASGKVIQLEYAALVIELCEKAAARDPFVVDDGVNIYKGIYALCGRNPTLPMFNSLLAMCRAGNNVQSAVFFVKEMAKLGLVPNGETFEHLLFLCLKTGNFKSAYLYLDDLYKRGFKVRIRLRNEMLRLCAESDDEYAAKLLEHKEHPQLGKTAAQRERYKRQRAKYKERRKEKRKATSIAKAGEEEGWEDYEPSLSTPEDLVAKTEKVKTAVEQKPTET
Protein: Auxin-induced protein IAA4 (P49679)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression (By similarity).
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MEFKATELRLGLPGITEEEEKKIIHGSSVVKNNNKRQLPQTSEESVSISKVTNDEHIVESSSAAPPAKAKIVGWPPIRSYRKNSLHEADVGGIFVKVSMDGAPYLRKIDLRVYGGYSELLKALETMFKLTIGEYSEREGYKGSEYAPTYEDKDGDWMLVGDVPWDMFVTSCKRLRIMKGTEAKGLGCGV
Protein: Cyclin-P (Cyclin N-terminal domain-containing protein 2) (Q9H8S5)
Organism: Homo sapiens (Human)
Function: Seems to be involved in the regulation of proliferation and migration.
Subcellular location: Nucleus {ECO:0000269|PubMed:28860486, ECO:0000269|PubMed:30087414}.
Interaction partners:
- Cyclin-dependent kinase 2
- Cyclin-A2
- Cyclin-A1
- Cyclin-dependent kinase 1
- Cell division cycle protein 20 homolog
- Cell division cycle protein 20 homolog B
Sequence:
MLVRGRDQGSGSRLGPIVRRWAPRPSPLQSLAASLDAEPSSAAVPDGFPAGPTVSPRRLARPPGLEEALSALGLQGEREYAGDIFAEVMVCRVLPLRALPRAVTPEMRALVVDWLVQVHEYLGLAGDTLYLAVHLLDSYLSAGRVRLHRLQLLGVACLFVACKMEECVLPEPAFLCLLSADSFSRAELLRAERRILSRLDFRLHHPGPLLCLGLLAALAGSSPQVMLLATYFLELSLLEAEAAGWEPGRRAAAALSLAHRLLDGAGSRLQPELYRCSLGGGSVWGHRSFRDLPSWSFLRSRRMRDNY