wanglab/gogpt-training-data huggingface dataset:
Protein: AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) (Q14865)
Organism: Homo sapiens (Human)
Function: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
Interaction partners:
- Lysine-specific demethylase PHF2
- CCAAT/enhancer-binding protein epsilon
- UPF0547 protein C16orf87
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- Histone deacetylase 1
- Protein polybromo-1
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Sequence:
MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGFHAGPVKTEALGRNGQKEALLKYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSDGKAVAKVKCEARSALTKPKNNHNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQDAAEVSSEQEKEQETLISQKSIPEPLPAADMKKKIEGYQEFSAKPLASRVDPEKDNETDQGSNSEKVAEEAGEKGPTPPLPSAPLAPEKDSALVPGASKQPLTSPSALVDSKQESKLCCFTESPESEPQEASFPSFPTTQPPLANQNETEDDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIARDDLCSSLSQTHHGQSTDHMAVSRPSVIQHVQSFRSKPSEERKTINDIFKHEKLSRSDPHRCSFSKHHLNPLADSYVLKQEIQEGKDKLLEKRALPHSHMPSFLADFYSSPHLHSLYRHTEHHLHNEQTSKYPSRDMYRESENSSFPSHRHQEKLHVNYLTSLHLQDKKSAAAEAPTDDQPTDLSLPKNPHKPTGKVLGLAHSTTGPQESKGISQFQVLGSQSRDCHPKACRVSPMTMSGPKKYPESLSRSGKPHHVRLENFRKMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPSKEVSGKEKASEQESEGSKAAHGGHSGGGSEGHKLPLSSPIFPGLYSGSLCNSGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPSSQLSSVHPSTKL
Protein: Homeobox protein MIXL1 (Homeodomain protein MIX) (mMix) (MIX1 homeobox-like protein 1) (Mix.1 homeobox-like protein) (Q9WUI0)
Organism: Mus musculus (Mouse)
Function: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12619131}.
Interaction partners:
- Eomesodermin homolog
- T-box transcription factor T
- Transcription factor SOX-17
- Hepatocyte nuclear factor 3-beta
- Forkhead box protein H1
- Homeobox protein NANOG
- T-box transcription factor TBX6
- POU domain, class 5, transcription factor 1
Sequence:
MAAAGSQQLQFAEGAAFPIFPAAHPGGQLLPAMRPASGLPAAPHDSRAPAATQCFPNRDSSPTAQTPAGLDPPGPSKGSAAPSAPQRRKRTSFSSEQLQLLELVFRQTMYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLSSRRGVFLHCPAPGTEARCLKPQLPLEADVNHVPDPSMTGGGVCTSGSQSFETYSSLSEDIGSKLDSWEEHIFSALGNF
Protein: Phosphodiesterase (EC 3.1.4.-) (A0A0G2JZX9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
IIFKRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAVHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNIRSSLQQPEGIDRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKPESSNYGASSSSTMIGFHVADALRRSNTKGCMSDGTYAPDYSLSAVDLKSFKNNLVDIIQQNKERWKELAAQEPKPILQEQRCC
Protein: Eyegone, isoform A (Eyegone, isoform B) (Eyegone, isoform C) (Q9VTX7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Protein Optix
- Protein phosphatase eya
- Protein sine oculis
- Homeobox protein homothorax
- Mitochondrial import inner membrane translocase subunit Tim22
Sequence:
MLIEPTLNRDLGSLTVANSGLSAAHWKMEPHPQRITSLAPHASSVAAASVAAAAAAAAAAAAAAAGAGSGAVAGGGGATSTSPTSVQIPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAVSKLLGSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINRILRNRAAERVATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPPPSALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPTNRAISPGSGSHDTLESADENRHIDSDYLDDDDEPKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVWFSNRRAKWRRHQRMNLLKRQRSSPANPLHSQQSNDAPASSPTPSNHSSASTSAPVAPVPPPQQPLPLCGDHSPQGPPPSVLLHPLHGPPGGHHHHHPLHLPTHPAALQLLSHYHQQQQQQQQQQHQQQQQQHHQQQQQLSPSGCNPAANHLSMGGERSAFRSLVSSPSAAAFLGLARQYAVAASLTVAEEQRSRLHYSAGGLGSGGEGTGPNTNTTQSGGSTMTVDNSSSDSDEEINVHDDSDGEIESSAATAAKVARLSSSDAPATLQFLKHDR
Protein: Eukaryotic translation initiation factor 2A (eIF-2A) (Q9VNX8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit B
- non-specific serine/threonine protein kinase
- 5'-3' exoribonuclease 1
- X-box-binding protein 1
- Small ribosomal subunit protein eS6
- Eukaryotic translation initiation factor 2 subunit 1
Sequence:
MAAAADLVVPTLAIRSSVAVELWSSAGSKQPFEHKPHLPREETKSSRSICFSSNGRYFAYSNGQEVKVLQASRDSAASWPVICVLPRPKAFYLQFSPRGSYLCTWEHYAITKDRPEGSPNLLVYEVATGVEVFAIVQKNQADWQPSWSADESIFALVVGGEALFYDLGEGAEKGFATTSRKIGGSRGGMLSLGPGNCPPFLAFYTPGAKGAPSMCKLYKYPALGQNQTVACKSFFQADRVEMLWNKRGSGLLLLTSTEVDKSGASYYGNQAVHFMATKGDTCSVPLSKEGPVHCVKWSPKATEFVVVYGFMPSKAALYNLKCDVVFDFGEGPRNCAYFNPFGNLIALAGFGNLPGAVEVWDVSKREKLANLKCADTTVFEWHPNGEWFVTATTAPRLRISNGFKVYHYSGALLHETMWPQGQELLGIEWQQFADKTFSEPKITKAKHEGIKSSQPEASKKAYTPPHLRLLKEGKNPEKYLPQPSIPGLAPTAAAGGVNGNKRNNKNKQRSARKDVNVVNGGDADSAPTEVVDQAAPVARQSPVFVAAEERKPQHTPRQKYQPDNAADQPPNSYGQGHPNGQHISDKERKIRSVAKKLSDIKKLKVRRSQGENLELNQLNKIKMEAQYLDELKALKQSA
Protein: Adenosine receptor A2a (P29274)
Organism: Homo sapiens (Human)
Function: Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P30543}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30543}. Note=Colocalizes with GAS2L2 at neuronal processes. {ECO:0000250|UniProtKB:P30543}.
Interaction partners:
- D
- Guanine nucleotide-binding protein G
- Metabotropic glutamate receptor 5
- Guanine nucleotide-binding protein G
- Cannabinoid receptor 1
- Guanine nucleotide-binding protein G
- BDNF/NT-3 growth factors receptor
- Adenosine receptor A2b
- Guanine nucleotide-binding protein G
- Pro-opiomelanocortin
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
Protein: Ferredoxin--NADP reductase (FNR) (EC 1.18.1.2) (Ferredoxin--NADP(+) reductase) (FPR) (Q9HYK7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- ferredoxin--NADP
- Bacterioferritin-associated ferredoxin
- Probable transcriptional regulator
- Heme oxygenase PigA
- Bacterioferritin BfrB
Sequence:
MSNLYTERVLSVHHWNDTLFSFKTTRNPGLRFKTGQFVMIGLEVDGRPLMRAYSIASPNYEEHLEFFSIKVPDGPLTSRLQHLKEGDELMVSRKPTGTLVHDDLLPGKHLYLLSTGTGMAPFLSVIQDPETYERYEKVILVHGVRWVSELAYADFITKVLPEHEYFGDQVKEKLIYYPLVTREPFRNQGRQTDLMRSGKLFEDIGLPPMNPQDDRAMICGSPSMLEETSAVLDSFGLKISPRMGEPGDYLIERAFVEK
Protein: Palmitoyltransferase (EC 2.3.1.225) (A0A0B4KF56)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGNDDHRRRKTPCGFCMAVFKWIPVLFITAVIAWSYYAYVVELCIRNSENRIGMIFMLLFYHLFLTLFMWSYWRTIMTSVGRIPDQWRIPDEEVSRLFRADSPDTQKRILNNFARDLPVTNRTMNGSVRFCEKCKIIKPDRAHHCSVCSCCVLKMDHHCPWVNNCVNFYNYKYFVLFLGYALVYCLYVAFTSLHDFVEFWKVGAGQLNASGMGRFHILFLFFIAIMFAISLVSLFGYHIYLVLVNRTTLESFRAPIFRVGGPDKNGYNLGRYANFCEVFGDDWQYWFLPVFSSFGDGKTFPIRHMEEDTESLLGYHSDTRIELEEDFLPEPRFQDSIPXLIMTSDNVATYYI
Protein: Neuroligin 4-like (Neuroligin-4) (NL-4) (B0F2B4)
Organism: Mus musculus (Mouse)
Function: Cell surface protein involved in cell-cell-interactions. Plays a role in the formation or maintenance of synaptic junctions via its interactions (via the extracellular domains) with neurexin family members. Plays a role in synaptic signal transmission.
Subcellular location: Cell membrane; Single-pass type I membrane protein. Postsynaptic cell membrane. Note=Detected at glycinergic postsynapses in retina. Detected on dendritic spines on cultured neurons.
Interaction partners:
Sequence:
MPAPVPALLCLALALASAQPSPPPPPPFPVVATNYGKLRGVRAALPGDVLGPVTQFLGVPYAAPPTGERRFQPPEPPSSWAGVRDATRFAPVCPQHLDERALLRDCLPAWFAANLDAIAAYVQDQSEDCLYLNLYVPGGANGKKMADDVTGNDHGDDQDSRDPGVGGAAAAAARKPVMVYIHGGSYMEGTANIVDGSVLASYGDVIVVTVNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWVEENAGAFGGDPDRVTVFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPARYARALGERVGCATPDPGSPPGSPPGWDSASLVSCLRGKAAGELARARVTPATYHVAFGPTVDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGARFVDGLGGGHDGGYGGYGGGYGGGVEDDEVQDGGPDGAAGGVSAGEFDLAVSGFINDLYGRPEGRGDALRETVKFMYTDWADRDSPEARRKTLVALFTDHQWVAPAVATADLHARYGSPTYFYAFYHRCHGGGGGGGGVDGVAGGVAGGVGGEEARPAWADAAHGDEVPYVFGVHMAGPGDVFGCNFSRNDVMLSAVVMTYWTNFAKTGDPNQPVAQDTRFVHTRPNRFEEVAWAKYDPRGQLYLHIGLRPRVRDHYRAAKVAFWLELVPHLHGLAADPGAYLSAAATRAAPSGDPDRDPGGGGGGRRRPRPATRRPAVMTSSSMASGSGMTSSSGSGMTSSSGSSASAVLIETRRDYSTELSVTIAVGASLLFLNVLAFAALYYKKDKRRHETHRRPPPPRPPQAPPSAAAADRNPRPDPGPAGRRGGECGAVVTAMAAEASAGGLGHDGVGGVGVGGVIGGVAGLRLACPPDYALTLRRSPDDVPRAGAGPGTMTLIPGALGGGGGGAVHGFNTFGSGVGVAGVAGVATSQAGPGLPHGHSTTRV
Protein: Acetyl-coenzyme A synthetase (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) (P16928)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Malate synthase, glyoxysomal
- Aldehyde dehydrogenase
- 2-methylcitrate synthase, mitochondrial
- Citrate synthase, mitochondrial
- Aldehyde dehydrogenase
- acetyl-CoA C-acetyltransferase
- Acyl-coenzyme A oxidase
- Acetyl-CoA hydrolase
- Uncharacterized protein
- aldehyde dehydrogenase
Sequence:
MSDGPIAPPKPAVVAEAHEVDTFHVPKAFFDKHPSGPHLKNLDEYKKLYEESIRSPDVFWARKARELLTFDKDFQTTRIGSLENGDVAWFPEGRLNASFNCVDRHAIKNPNKVAIIYEADEPNEGRTITYGELLREVSRVAWVLKQRGVKKGDTVAIYLPMIPEAIIAFLACSRIGAVHSVVFAGFSSDSLRDRVLDAGSKVVITTDEGKRGGKVIGTKRIVDEGLKQCPDVSTVLVYKRTGAEVPWTEGRDIWWHEEVEKYPAYIAPDSVNSEDPLFLLYTSGSTGKPKGVMHTTAGYLLGAAMTGKYVFDIHDDDRYFCGGDVGWITGHTYVVYAPLLLGCSTVVFESTPAYPDFSRYWDVIEKHKVTQFYVAPTALRLLKRAGDHHIHHKMEHLRVLGSVGEPIAAEVWKWYFEKVGKEEAHICDTYWQTETGSNVITPLAGVTPTKPGSASLPFFGIEPAIIDPVSGEEISGNDVEGVLAFKQPWPSMARTVWGAHKRYMDTYLNVYKGYYFTGDGAGRDHEGYYWIRGRVDDVVNVSGHRLSTAEIEAALIEHPMVAEAAVVGIADELTGQAVNAFVSLKEGNETNDQVRKDLILQVRKSIGPFAAPKAVFVVDDLPKTRSGKIMRRILRKILSGEEDSLGDISTLSDPSVVERIIATVHASRGK
Protein: Integral membrane protein (Q9K3P6)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Interaction partners:
- Integral membrane protein
- Hydrolase
- UDP-glucose 4-epimerase
- Integral membrane protein
- Membrane protein
- TetR-family transcriptional regulatory protein
Sequence:
MQTPPVDSPPAPPQPRTALRVTWVLTVCSALLLTLVAVEWRPLLRLDEDIAGTTHRWAVEEGGLTHAMRILTDWVWDTWTMRLLCAVVVLWLWWRRADRWTAVWLGATCLLGSLLQQALKAAVDRPRPVWPDPVDSAHYAAFPSGHAMTATFVCGLLVWLLHHYDTGRGPRRTGMAVAVVSVAGVGVTRVWLGVHWATDVLGGWLLGGLVVALAVVVHRRGHP
Protein: La-related protein 7 (La ribonucleoprotein domain family member 7) (D6RFF0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSS
Protein: Chitin biosynthesis protein CHS6 (Protein CSD3) (P40955)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16498409, ECO:0000269|PubMed:17000877, ECO:0000269|PubMed:9614194}; Peripheral membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16498409, ECO:0000269|PubMed:17000877, ECO:0000269|PubMed:9614194}. Note=Trans-Golgi network location requires interaction with CHS5 and with myristoylated GTP-bound ARF1 for the recruitment to the membranes.
Interaction partners:
- Protein BCH2
- Chitin biosynthesis protein CHS5
- Chitin synthase 3
- Protein BCH1
- Bud site selection protein 7
- ADP-ribosylation factor 1
- Chitin synthase export chaperone
- Chitin synthase regulator SKT5
- Chitin synthase 2
- Chitin synthase 1
Sequence:
MNLFWPSETKKQNEIPGGDYTPGNSPSVQKGYQFLNRDIFKSCPRIMERQFGECLHNRTHLIKDLISSGNVGLGPIEIVHMSYLNKHEKEEFGEYFYVTGIEVSGPAMPVEFLEVLKSSKRISKNISNNIILTYCCFNFFSNLDIRIRYDADDTFQTTAIDCNKETTDLTMTEKMWEETFASSVIRAIITNTNPELKPPGLVECPFYVGKDTISSCKKIIELLCRFLPRSLNCGWDSTKSMQATIVNNYLMYSLKSFIAITPSLVDFTIDYLKGLTKKDPIHDIYYKTAMITILDHIETKELDMITILNETLDPLLSLLNDLPPRDADSARLMNCMSDLLNIQTNFLLNRGDYELALGVSNTSTELALDSFESWYNLARCHIKKEEYEKALFAINSMPRLRKNDGHLETMYSRFLTSNYYKKPLNGTREHYDLTAMEFTNLSGTLRNWKEDELKRQIFGRIAMINEKKIGYTKEIWDDIAIKLGPICGPQSVNLINYVSPQEVKNIKNINLIARNTIGKQLGWFSGKIYGLLMEIVNKIGWNGLLNIRTEAFMMETEFYQASNNIIDENGHIPMESRKKRFCEGWLDDLFLDLYQDLKLSKISLSNKDEKHSGLEWELLGLIMLRTWHWEDAVACLRTSIVARFDPVSCQQLLKIYLQPPKNIQEVTLLDTDTIISLLIKKISYDCRYYNYCQIFNLQLLEKLCNELGTHILRNKILLQPSIGDEIMVMIDAMLAWIADLDHTVQP
Protein: MIND complex subunit (Q59YF9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000256|ARBA:ARBA00004629}.
Interaction partners:
- DASH complex subunit DUO1
- Histone H3-like centromeric protein CSE4
Sequence:
MSDKTLDERTTAILTEHLEFAPLTLIDDVINAVNEIMYKGTTAIETYLKEQKQLMKNGIFTKVTEDEIEIGMGKLESLLESTIDKNFDKFELYCLRNIFNIPKDLIPYIQLSHQQGIEFKSDNVEQKREFDQQIKNLQLKIMQELQLRKILKLQLVKVQKLIKVLIAIDNDFKKIDFASGGGGNEESIRILKNLQPIDETLYFLISQIKNLINQIEQLSNKVNTNLKTQKFIPNLRDKFIDGRTFRVLQQTGIWKDLEKNDIKISVQGNDNNNNNNNNNNNTLTDLQNQDDIDMIIPEQDDIDVDAIKNINAQI
Protein: Down syndrome cell adhesion molecule 1, isoform BI (A0A0B4K7H9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVSQHYEEDIHKAFVIRGNSAILKCDIPSFVADFVNVISWHSDEKENFYPGTEYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITGHCCLSDYSIRFIGMWFLSQLRPMIVLKCPSQTYPLPACRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVPPQVMPFVFGEEPSNYGDSTAVQCMVFKGDTPLQLHWTLNGQPITNEHVGIRIIKMSPKLSSLSIDAINGQHRGLFKCIATNAAGTSEQSAELMVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQQANGAGFTAYDTMAV
Protein: Copper transport protein ATX1 (Copper chaperone ATX1) (Q94BT9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays an important role in copper homeostasis by conferring tolerance to excess of copper and subclinical copper deficiency during vegetative stage. Can complement the yeast mutants atx1 and sod1.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17223078}.
Interaction partners:
- Cytochrome c biogenesis protein CCS1, chloroplastic
- Superoxide dismutase 1
- Probable copper-transporting ATPase HMA5
- Copper chaperone for superoxide dismutase, chloroplastic/cytosolic
- Copper-transporting ATPase RAN1
- Cytochrome c oxidase subunit 5b-1, mitochondrial
- Squamosa promoter-binding-like protein 7
- Superoxide dismutase 2, chloroplastic
- At4g21108/At4g21108
- Cytochrome c oxidase copper chaperone 1
Sequence:
MSQTVVLRVAMTCEGCVGAVKRVLGKMEGVESFDVDIKEQKVTVKGNVQPDAVLQTVTKTGKKTAFWEAEGETAKA
Protein: Bifunctional lycopene cyclase/phytoene synthase [Includes: Lycopene beta-cyclase (EC 5.5.1.19) (Lycopene cyclase); Phytoene synthase (EC 2.5.1.32)] (Q67GH9)
Organism: Blakeslea trispora (Choanephora trispora)
Function: Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSILTYLEFHLYYTLPVLAALCWLLKPFHSQQDNLKYKFLMLMAASTASIWDNYIVYHRAWWYCPTCVVAVIGYVPLEEYMFFIIMTLMTVAFSNFVMRWHLHTFFIRPNTSWKQTLLVRLVPVSALLAITYHAWHLTLPNKPSFYGSCILWYACPVLAILWLGAGEYILRRPVAVLLSIVIPSVYLCWADIVAISAGTWHISLRTSTGKMVVPDLPVEECLFFTLINTVLVFATCAIDRAQAILHLYKSSVQNQNPKQAISLFQHVKELAWAFCLPDQMLNNELFDDLTISWDILRKASKSFYTASAVFPSYVRQDLGVLYAFCRATDDLCDDESKSVQERRDQLDLTRQFVRDLFSQKTSAPIVIDWELYQNQLPASCISAFRAFTRLRHVLEVDPVEELLDGYKWDLERRPILDEQDLEAYSACVASSVGEMCTRVILAQDQKENDAWIIDRAREMGLVLQYVNIARDIVTDSETLGRCYLPQQWLRKEETEQIQQGNARSLGDQRLLGLSLKLVGKADAIMVRAKKGIDKLPANCQGGVRAACQVYAAIGSVLKQQKTTYPTRAHLKGSERAKIALLSVYNLYQSEDKPVALRQARKIKSFFVD
Protein: Endothelin-1 (Preproendothelin-1) (PPET1) [Cleaved into: Endothelin-1 (ET-1); Big endothelin-1] (P05305)
Organism: Homo sapiens (Human)
Function: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor.
Subcellular location: Secreted.
Interaction partners:
- Endothelin-1 receptor
- Endothelin receptor type B
- Endothelin-converting enzyme 1
- Endothelin-converting enzyme 2
- Endothelin-3
- Matrix metalloproteinase-9
- 72 kDa type IV collagenase
- Angiotensinogen
- Endothelin-2
- B2 bradykinin receptor
Sequence:
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW
Protein: Protein MOST-1 (Q9NRJ1)
Organism: Homo sapiens (Human)
Function: May be involved in cell survival, proliferation and progression of cancer cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17143515}. Microsome membrane {ECO:0000269|PubMed:17143515}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17143515}.
Interaction partners:
Sequence:
MGECPHLVDVRLGHRSLATGPEQSDICHTGSEARWTTTWYGSLSFSRHKYKMLADLTPGVEMSCRHWARWLTPVIPALWKAEAGGLPELRSSRPAWTTW
Protein: Dynactin subunit 5 (Q5B358)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Dynactin subunit 4
- Dynamitin homolog
- Arp11 homolog
- P150 dynactin NUDM
- F-actin-capping protein subunit beta
- Actin, gamma
- Actin-related protein
- Cytoplasmic dynein intermediate chain
- Dynein heavy chain, cytoplasmic
- Dynein light intermediate chain
Sequence:
MPPKAPKGEYIETETGNKVSRRSQIHGTHHISLGGKSIIMADAVVRGDLFRSSSSQSQSQSQSQSQSGSGAGNNNIAISIGRYTFISRSAILRPPSRLSRGVHTYTTLHIGSHVFVGERSIVEAAKVEDNVTIGKDCVIGSMAILKERCQVLDGCVVPGGMVVPSHCVVGGQPARIVGDTPIAYGVEGLEGGLSRERYRSIR