Protein: Guanylate cyclase beta (PfGCbeta) (EC 4.6.1.2) (Guanylyl cyclase beta) (Q8IDA0)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Catalyzes the synthesis of the second messenger cGMP from GTP. Regulates cGMP production in gametocytes; however, is dispensable for the initiation of gametogenesis. Does not have adenylate cyclase activity.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- cGMP-specific 3',5'-cyclic phosphodiesterase delta
- pyruvate kinase
- Pyruvate kinase
- Bis
- Inosine triphosphate pyrophosphatase
- cGMP-specific 3',5'-cyclic phosphodiesterase alpha
- nucleoside-diphosphate kinase
- Nucleoside diphosphate kinase
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase beta
- GTP cyclohydrolase 1
Sequence:
MKTQTLSLMNINGKRKFLGTNNKIYRKVIINPTSEDDIQKFCRNYFRIYNFSLYNFIRRLISFDAILVYSLFLTVYIFSEINHGETKKYLFIDTAISLFFNIILLIVIESLFELKKLKDVKNANSQYYLRIVPKMSYFEKVMTKDIKVGNIIRIFQGDEFPADVVILYVKNNANAIVDSFKIDGLFRKSIKYAVDKYKIDKDYLKMLSEINGVIRCELPNKNIFCFQGNFKLDKHPRSLLLNYENFALQSSVLKGAEYIDAVVVYTGADTKKNLNIPQKIEENKTFCIKMNNIVYYLIFMYFVFVVLSIVIKTIFFHKKNSFQNSRDSFLSMLEDFVGLYILVLPIMMYSEKSLIYIIQSLRIENDLRMRNTDSEKPKVFNKNKNDSLGNVDLLATSRNGVLVKRKELLVSCVINNVMYGKKDIICSRTNFKLPTLNILDSERKNVSNLLNLDERIFKDPENIFFPTRDFYSFLKLFENKISSIYNPYSSSLSNLLKEKYKNYVNEEILNKNVKLTSFVKSQLTIGYNQICEDDELSYNCYEIKEDSQKENIQSVKIEDFILGLCGCNRIIIYNEKSLDISMNEYKSDNFMETYSKFETENEEYHENDHDEYHNMEHSDDENINSIEYEDICLYNIIRNTGFSIYCYKNTLFLYNLMKECKVYFLTCYHDFLRSNKFSMCILKCGYSINNEKEGGILYVRGYDFNILPYISKEKNNIKKIKNVIKIYTLNYLKVIILCKKQISNEDIAKYIILKSISKKLSFKFYDLIKLFFLYDLEVIGIIGLKNQLREGVKETFNDVINFDIKSWIFANECSKDTYLTALQCNLIVSSSNLFLINYYNLKNTHEEGANILFHNFISSLYKLKSNSYAVVINDESIKNIMTNVESMKIFLCIAMRATVVLFCKLQNETKGKIIRTLYALTSPKLTVLGIGTTLNDAYLLKYSSISVFLSLNEHVNILYNISDYVLQEFKFISELLILGRLNRFSLCKVFLWIIYLKITVVSFYFFHNFDNYFSGSSASSILYTQTTFALLHYFLIIAFSAYEIDLPYKFVRRLPYIYQLSRRKYFLNNNIILLTIIEAILISLTSYYILRLNVFHLITHREFTFHIFILNVFITTEKILLLSKTWHIYFFIMAVLIIGILLIYVNIFTLVDCIKNGKCEFSLFQMENIYFWTSLFPILYINFIFDKLMKYIKNRIYPDISDYLRKYFLRRICCHNNDKFLSQRKIKGINKFVNFEKNDILLKYIPTPKIYKIKDDPTYYNKSKRSKFLYDTFRKVIDINVKYRNQQLNLEYKTYEKGNKLKLRIIVILLFLIYIIIFSSQTIIDINTKSNIHYITMFYIIYFVLACVLLIYIRIRNKATSTFFFFLSRFLLICGFCIELYDNISNDILNVLITYSFTVSYIFFMSFKILEALLVCISILLLTFGVYYEKNKNMIDICTHFCSNPYLSINNLDHMNISCLCKKQIVIFLISLLSFTLICLSMKYYEIFYLKKKFLFRYKQKVNLAKQIEILHTMLPNFLVEYLLISDPKNDGIMVGKNISGEDRGIISVIFCDIDDFQNMVSTLQPHVLVETLDNLYLYFDKCIKYFNCIKIETVFESYLAASGLSEKKNNALDKIMYDTKCAIKLAIAQLSAKYYISYKVLDTREHFSDNSTSYDKYINKNISLKIGIHTGKAISGVIGSVKPQYALFGDTVNTASRMKSTSLPDHIHVSYDTYKYLKEDNTFIWKERKVFIKGKGKMKTYLLVDILDDVKRKGESLNYYSSSNLLLSQLGSEAVSIYEEREDIKEGSMDIIKESSRDIIKEDSRDIIKEISTNISKSSSRNISKSSSRSISDIKEGQIIDKEDLIFKINRMKNKIDSRYSKRIDKESRDKISDKTNHVLDEVVKHSDIHLLNYEINNKRCKKMKGDTNNENKLIGDIFNMYDKKIKYIYKKNYKSKSMENISFIKHYRNTKYKKSDYLLLDNKGESKKFKRNTSYVLESPLHLIGDIVDNNIKRKKKKKEIKTIVSDDMFTSPVNIKEYNYNEQERKKEIVGNLSYDKTKKIFPFIKFTKEGRIKKKKIEKKEKKEKKENNNNFLYNDDYSSYSSPKYGDNENNFVIKYIRERKDFQKKFDHPNFNFSKFLHNYNPMKNKNKNKKNNKNVRRNEYPNYTSSSKDGVSYNFLSDSLFSSDNEYSSDNEYSSDSEKYYKKRFKKNKKIIKFDDLFTKIYIKKKRLLQMNNYDVKGKGKKLKNKGMERNKTKYKNVNEITKMKYFVNNENRDHEVNKEDISKSMQKYFLHISKHKKEQIEDKKKTHKYFHKNVECVYPYAGNNINHNFSRNEKRKYSINLYDHLDEQEKIKGKKKYFNKDKELIGSINKQTERKPKKKNKKNIENKKDKKKIRMITNKTKEKHSNSIISVEEQNMNHNNSLKKKEVNFTGKNEEYLNRANTNCSLGIKEMEEDVYEFHSNNIYYNNQTSYSDDINNTTKLKGMGNNTNDISKNKGKNKLGKKISFFSMNNKYHESEIMNEEDNKNMLNLTQSQIINKDKYNYFTHCPSLKKKKSVFTKINNLFKNYFKSIDVHEKFGFSKKFKFHSKDSDDIKGNNNKISKNRYNNNNNNNNSNYSNIDSGKYSHNNKKNHHHNNNKYHHHNNNKYHHHNNNKYHHQNNNYEKHHHSNNSRVMLSKGEKTEKNENVDYAYQFDNYDKKLLKKLTSNLQLNKKNVKNFNMFYYKFNDEELEEEYTRNYYREIINIDLTKKLIIIFIFTEIFLSLCNIIELSFYEKKLRYNDSIVIIWLIRSIYLFIITYIWIILKTKLKEYKNNSSKMMWTIFILNIFLCSWGIILIDLSCIHYSMLLGNKNERALFFMKDASELIICIQLIFIKNMLFKHKFFFFVFFYIFLIYSFSKLFSIHTCQTHICCSIILFISINILYFWYSEYLDRIQFLVKRKRNRMEKISQDFLTKILPRQVLEEYQNDNLQLTYKHEKIAFLFADIVGFTKWSKTVSPKEVLKLLQKLISKIDKDTIKLGLYKLFTIGDAYVATSQPNSSITDESEALEGILNILKLAKLILHNINTIKIQFNKHDFNMRIGLHYGSCVGGIIGSVRIRYDMWGLDVLIANKIESNGIPGEIICSEQFRHFFIQNEPQAKLNFWYYKSISINDQDIKLYVIEDKNYEEDYDPKVIDYTTLLKLRQKKGLRS