wanglab/gogpt-training-data huggingface dataset:
Protein: Transcriptional regulator (A0A1D8PGK8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Ino4p
- Inositol-3-phosphate synthase
Sequence:
MTAPSISNQQLPPPPYSKTDNLPTSNYQSSLNGSVQGQDQQVQAQVQGQAPELVSAAETLTSLTRNGTPPSDADTVAMDDAQSPVILPPIHPQHQRHPIVSTVSMVARHPIVMNAVKYYETSKRNYPSFNYAAGIVESAAIPVVNNIEAKLNTRHQTRQASAVSSTDITPTNSNFGDYKIQHDGKNSLQKKRRFSASSQTTNISSYSSIDTKKRLQFCINILKLANTNISSKVEFLQEKIDETEIAVKEEREKLIAQKSHDSNSTNTTEQATQKTKTEIVGTVKKIIHLISNFRPSSLGDTSVTNGLSPVSSNGSQSNQDFELKNAIRDIIMSLPQSLQQQQQQQSGPPSNSQDDVIFKFAKESLVMISKLTQIFTEKLDQVEHWVNGDEEQEQKLQSQSQSPEGLEKQQEDEREEENLAAETKRMKLDGSV
Protein: V-type proton ATPase subunit a (F6XRE6)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
XDLKVNFVAGAVEPYKAAALERLLWRACRGFLIASFRETEGQLEDPVTGEPATWMTFVISYWGEQIGQKIRKITDCFHCHVFPYLEQEEARFRTLQQLQQQSQELQEVLGETDRFLSQVLGRVQQLLPPWQVQIHKMKAVYLTLNQCSVNTTHKCLIAEVWCAARDLPTVQQALQSGSLPTPSSHSPFSSL
Protein: Probable serine/threonine-protein kinase WNK6 (AtWNK6) (EC 2.7.11.1) (Protein kinase with no lysine 6) (Q8S8Y8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May regulate flowering time by modulating the photoperiod pathway.
Interaction partners:
- Two-component response regulator-like APRR3
- Transcription factor bHLH157
Sequence:
MEGTDDASALQEPPDPEVLEVDPTFRYIRYKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNGLTMNNPLPLPDIVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLDEDSNLPIVTFSDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWKTDVTVDHLIHSQLNQNSRSHHNEAKPQKQEETVFHDTCELVSHSCNSDCPRSDEEDKQCVDATKGEDKSSIQEVEEATEPVSLEEEERLRQELEEIEAKYQEDMKEIATKREEAIMETKKKLSLMKLK
Protein: GID complex substrate-recognition subunit 4 (Glucose-induced degradation protein 4) (Vacuolar import and degradation protein 24) (P38263)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Substrate-recognition component of the GID complex, a multisubunit ubiquitin ligase that targets enzymes involved in gluconeogenesis for proteasomal degradation when cells are shifted to glucose-containing medium. Specific for substrates with an N-terminal Pro (Pro/N-degron), including FBP1, ICL1 and MDH2. Has high affinity for the N-terminal sequence Pro-Thr-Leu-Val, and can bind peptides with an N-terminal sequence of the type Pro-[Gly,Ala,Ser,Thr,Asp,Asn,Tyr,His]-[Ala,Val,Leu,Ile,Lys,Arg]-[Val,Cys,Pro,Leu,Ile,Trp]. Required for vacuolar degradation of FBP1 when cells are shifted to glucose-containing medium, probably by targeting FBP1-containing vesicles to the vacuole, but is not required for FBP1 sequestration in cytoplasmic vesicles.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9508768}; Peripheral membrane protein {ECO:0000269|PubMed:9508768}. Note=Colocalizes with FBPase-containing vesicles. {ECO:0000269|PubMed:9508768}.
Interaction partners:
- GID complex subunit 9
- GID complex subunit 5
- GID complex subunit 8
- GID complex subunit 1
- E3 ubiquitin-protein ligase RMD5
- GID complex subunit 7
- Fructose-1,6-bisphosphatase
- GID complex associated protein 12
- GID complex substrate-recognition subunit 10
- Malate dehydrogenase, cytoplasmic
Sequence:
MINNPKVDSVAEKPKAVTSKQSEQAASPEPTPAPPVSRNQYPITFNLTSTAPFHLHDRHRYLQEQDLYKCASRDSLSSLQQLAHTPNGSTRKKYIVEDQSPYSSENPVIVTSSYNHTVCTNYLRPRMQFTGYQISGYKRYQVTVNLKTVDLPKKDCTSLSPHLSGFLSIRGLTNQHPEISTYFEAYAVNHKELGFLSSSWKDEPVLNEFKATDQTDLEHWINFPSFRQLFLMSQKNGLNSTDDNGTTNAAKKLPPQQLPTTPSADAGNISRIFSQEKQFDNYLNERFIFMKWKEKFLVPDALLMEGVDGASYDGFYYIVHDQVTGNIQGFYYHQDAEKFQQLELVPSLKNKVESSDCSFEFA
Protein: CCAAT/enhancer-binding protein (A5X2V8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005879}.
Interaction partners:
Sequence:
MEQPNLYEVAPRPLMTSLAQSQSQQSAYCYKDPSAAGPGAGGDLGEICENENSIDISAYIDPAAFNDEFLADLFHNSSKQEKLKLANSEYESYPHGVSSGSGAHHHQQQQQQHQQQGYGCIPGYMDTSKLEPIYDNQSTRIRPVAIKQEPREEDEMSHSMPPTYHHSHQHLPQHLSHLQYQIAHCAQTTMHLQPGHPTPPPTPVPSPHHRDGSMSSVGSMKMMGRDDRDRDRDRGKSKKRVDKASTEYRLRRERNNVAVRKSRDKAKMRNVETQHKVIELASDNERLRKRVEHLTRELDTLRGIFRQLPDGSFKPLANCQ
Protein: Protein numb homolog (h-Numb) (Protein S171) (P49757)
Organism: Homo sapiens (Human)
Function: Regulates clathrin-mediated receptor endocytosis. Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:18657069}; Peripheral membrane protein {ECO:0000305|PubMed:18657069}; Cytoplasmic side {ECO:0000305|PubMed:18657069}. Endosome membrane {ECO:0000269|PubMed:18657069}; Peripheral membrane protein {ECO:0000305|PubMed:18657069}; Cytoplasmic side {ECO:0000305|PubMed:18657069}. Note=Localizes to perinuclear endosomes in an AAK1-dependent manner. {ECO:0000269|PubMed:18657069}.
Interaction partners:
- E3 ubiquitin-protein ligase Mdm2
- E3 ubiquitin-protein ligase LNX
- Neurogenic locus notch homolog protein 1
- E3 ubiquitin-protein ligase Itchy homolog
- Dihydropyrimidinase-related protein 2
- Epidermal growth factor receptor substrate 15
- Neurogenic locus notch homolog protein 2
- Numb-like protein
- Neurogenic locus notch homolog protein 3
- Neurogenic locus notch homolog protein 4
Sequence:
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL
Protein: Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) (Q9NRX5)
Organism: Homo sapiens (Human)
Function: Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7TNK0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7TNK0}.
Interaction partners:
Sequence:
MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAAVHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFVYYTHPASCSENKAFISVNMLLCVGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETNCNPSLLSIIGYNTTSTVPKEGQSVQWWHAQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGARSDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD
Protein: Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2) (P35561)
Organism: Mus musculus (Mouse)
Function: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21209095}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q64273}.
Interaction partners:
- Potassium voltage-gated channel subfamily KQT member 1
- ATP-sensitive inward rectifier potassium channel 12
- Inward rectifier potassium channel 4
- Potassium voltage-gated channel subfamily KQT member 5
- Potassium voltage-gated channel subfamily KQT member 3
- Potassium voltage-gated channel subfamily KQT member 4
- Potassium voltage-gated channel subfamily KQT member 2
- Endothelin-1 receptor
- ATP-sensitive inward rectifier potassium channel 14
- Guanine nucleotide-binding protein G
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
Protein: Protein pendolino (Q7K4V4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:26110638}. Chromosome {ECO:0000269|PubMed:26110638}. Note=Associates with multiple polytene bands and interbands on chromosomes. {ECO:0000269|PubMed:26110638}.
Interaction partners:
- Protein hook
Sequence:
MTLDLDAHKKDDKLLITTIQQEYKILAEYKMIESEKLSGIYVIPSYANSLQWFGVFFGRQGLYAESVFRFTILLPDRFPDDKSLPSIIFQQDVIHPHVCPYTHSLDVSHAFPEWRCGEDHLWQLLKYLQVIFSDPLDSIRGIEVDKLKNSEAAELLMNNKEEYVARVQENIKESKEHIFDTPPTEDPHYIVFEKFQQDVHGPVLERIKAGRSKLTEPSAQQANGGHATGLSWVKEGEFKPLSIE
Protein: Sll1837 protein (P73107)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
Sequence:
MVNKGLWSAAVMVLGSTLVGSVFAPTPAIAGKSCNYLNTNLFMAQGYENPNGIWVSEGWWVVEPGECVVYSDSAFTYFKISDGVAPNRKAIAEMAGSESIKLCQVNDRFTVFQSDSGAVCRNAGGNNQTFINPGANLELIESTSP
Protein: Pre-mRNA-processing protein 40B (AtPRP40b) (F4JCC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds the phosphorylated C-terminal domain (CTD) of the largest subunit of RNA polymerase II and functions as a scaffold for RNA processing machineries. May be involved in pre-mRNA splicing (Probable).
Subcellular location: Nucleus {ECO:0000269|PubMed:19467629}.
Interaction partners:
- U1 small nuclear ribonucleoprotein C
- AT5g17440/K3M16_10
- LUC7 related protein
- Arginine-aspartate-rich RNA binding protein-like
- Pre-mRNA-processing factor 39-2
- Tetratricopeptide repeat
- U1 small nuclear ribonucleoprotein 70 kDa
- RNA-binding motif protein 25
- Pre-mRNA-processing protein 40A
- Cell division cycle 5-like protein
Sequence:
MANNHQYPGIQPFQHPNASSIDLPRGFAPPMNFQFLPTIQAPQSEQVARLSSQNFQCVGRGGTVLSIGYPPQSYAPQLLQSMHHSHERPSQLNQVQVQHVPLGPPTLISQPNVSIASGTSLHQPYVQTPDIGMPGFGGPRALFSYPSATSYEGSRVPPQVTGPSIHSQAQQRASIIHTSAESSIMNPTFEQPKAAFLKPLPSQKALTDWVEHTSADGRKYFFNKRTKKSTWEKPVELMTLFERADARTDWKEHSSPDGRKYYYNKITKQSTWTMPEEMKIVREQAEIASVQGPHAEGIIDASEVLTRSDTASTAAPTGLPSQTSTSEGVEKLTLTSDLKQPASVPGSSSPVENVDRVQMSADETSQLCDTSETDGLSVPVTETSAATLVEKDEISVGNSGDSDDMSTKNANQGSGSGPKESQKPMVESEKVESQTEEKQIHQESFSFNNKLEAVDVFKSLLKSAKVGSDWTWEQAMREIINDKRYGALRTLGERKQAFNEFLLQTKRAAEEERLARQKKLYEDFKRMLEECVELTPSTRWSKTVTMFEDDERFKALEREKDRRNIFEDHVSELKEKGRVKALEDRKRNIIEYKRFLESCNFIKPNSQWRKVQDRLEVDERCSRLEKIDQLEIFQEYLRDLEREEEEKKKIQKEELKKVERKHRDEFHGLLDEHIATGELTAKTIWRDYLMKVKDLPVYSAIASNSSGATPKDLFEDAVEDLKKRDHELKSQIKDVLKLRKVNLSAGSTFDEFKVSISEDIGFPLIPDVRLKLVFDDLLERAKEKEEKEARKQTRQTEKLVDMLRSFKDITASSSWEELKHLVEGSEKCSTIGDESFRKRCFEDYVSLLKEQSNRIKQNKKVPEDVREEHDKGRDKYGREKDRVRERDSDDHHKKGAAGKYNHDMNEPHGKERRRSGRDSHNRHRERHTSVKENDTDHFKESHKAGGGHKKSRHQRGWVSEAEVEGKEKRRRKEEAREHTKEEELEDGECGRY
Protein: 4-hydroxybenzoyl-CoA thioesterase (4-HBA-CoA thioesterase) (EC 3.1.2.23) (Q04416)
Organism: Arthrobacter sp
Interaction partners:
Sequence:
MHRTSNGSHATGGNLPDVASHYPVAYEQTLDGTVGFVIDEMTPERATASVEVTDTLRQRWGLVHGGAYCALAEMLATEATVAVVHEKGMMAVGQSNHTSFFRPVKEGHVRAEAVRIHAGSTTWFWDVSLRDDAGRLCAVSSMSIAVRPRRD
Protein: Naringenin,2-oxoglutarate 3-dioxygenase (Naringenin 3-dioxygenase) (EC 1.14.11.9) (F3H) (Flavanone 3-hydroxylase) (Protein TRANSPARENT TESTA 6) (Q9S818)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R-dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants.
Interaction partners:
- Flavonoid 3'-monooxygenase
- Dihydroflavonol 4-reductase
- 2-oxoglutarate
- Chalcone--flavanone isomerase 1
- Chalcone synthase
- Probable chalcone--flavanone isomerase 3
- Trans-cinnamate 4-monooxygenase
- Anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase
- Flavonol synthase/flavanone 3-hydroxylase
- Flavonol 3-O-glucosyltransferase
Sequence:
MAPGTLTELAGESKLNSKFVRDEDERPKVAYNVFSDEIPVISLAGIDDVDGKRGEICRQIVEACENWGIFQVVDHGVDTNLVADMTRLARDFFALPPEDKLRFDMSGGKKGGFIVSSHLQGEAVQDWREIVTYFSYPVRNRDYSRWPDKPEGWVKVTEEYSERLMSLACKLLEVLSEAMGLEKESLTNACVDMDQKIVVNYYPKCPQPDLTLGLKRHTDPGTITLLLQDQVGGLQATRDNGKTWITVQPVEGAFVVNLGDHGHFLSNGRFKNADHQAVVNSNSSRLSIATFQNPAPDATVYPLKVREGEKAILEEPITFAEMYKRKMGRDLELARLKKLAKEERDHKEVDKPVDQIFA
Protein: Beta-glucosidase 22 (AtBGLU22) (EC 3.2.1.21) (Q9C8Y9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Beta-D-glucosidase active on scopolin >> esculin >> 4-MU-glucoside. No activity with DIMBOA-glucoside, pNP-glucoside, oNP-glucoside and sinigrin as substrates.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- PYK10-binding protein 2
- Beta-glucosidase 21
- PYK10-binding protein 1
- Beta-glucosidase 23
- Jacalin-related lectin 20
- Transcription factor NAI1
- Protein TEEBE
- TSA1-like protein
- Jacalin-related lectin 22
- Beta-glucosidase 46
Sequence:
MALQKFPLLGLLFLITIVVSSTIAVDDPVCPTTSKLSRASFPNGFVFGTATAAFQVEGAINETCRGPALWDIFCKRNPERCSGHNADVAVDFFHRYKEDIQLMKNLNTDAFRLSIAWSRIFPHGRKEKGVSQAGVKFYHDLIDELLKNGIIPFVTVFHWDTPQDLEDEYGGFLSENIVKDFREYADYVFTEYGGKVKNWITFNEPWVFAHAGYDVGKKAPGRCSRYLKGCEDRDGRSGYEAYLVSHNLLNAHAEAVEVFRQKVKGGKIGIAHSPAWFEPHDLKDSNDVPTVSRVLDFMLGWHLDPTTFGDYPQIMKDLLGHRLPKFTSSQKAKLKDSTDFVGLNYYTSTFSNHNEKPDPSTPSWKQDSLVAWEPKNVDHSAIGSQPLTAALPVYAKGFRSLLKYIKDKYANPEIMIMENGYGDKLKDKDSVEVGTADYNRKYYLQRHLLAMNEAICIDKVRVTGYFVWSLLDNFEWQDGYNNRFGLYYVDFKNNLTRYEKESAKYYKDFLGQGVRPSALKKDEL
Protein: Testis anion transporter 1 (Anion exchange transporter) (Solute carrier family 26 member 8) (Q96RN1)
Organism: Homo sapiens (Human)
Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.
Subcellular location: Membrane {ECO:0000269|PubMed:11278976}; Multi-pass membrane protein {ECO:0000255}. Note=Located at both the annulus and the equatorial segment of the human sperm head. {ECO:0000269|PubMed:17517695, ECO:0000269|PubMed:22121115, ECO:0000269|PubMed:23582645}.
Interaction partners:
- Rac GTPase-activating protein 1
- Anillin
- Cystic fibrosis transmembrane conductance regulator
Sequence:
MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV
Protein: Rho GTPase activating protein 6 (H7BYE6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
LELYDLQILGTKPPMNSDTHRNFDPTATLRNQGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKGNWSLASRRWPKQATLLLLHVAWCGALRTFSSSLPYLMFL
Protein: Glutamine synthetase (EC 6.3.1.2) (A8YXX4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN
Protein: PAR-1 ser/thr kinase N2 (Q7K9Q9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGQTSSHRQMHHSSNNNNKEEPPQPASQFGNRRTSTRKSTSSSKHYPTLVQPLRKDELSLLRDSLLRNGSIMRKNPERRPVTISELKPVNTGQGTSGSVLPITAEDAAGGSSSSITQLMAFQLPVDRSAKTDDLAAESSASAAAAVAPKEGRNEFYIVGDGYHRTDHCYYRSPNGDFHKLPSDSFHKMSEGCFVRMADGVFRRLEVPTKAQISRRSSRAEEIGDATSQGNGSAATNVKSQLMRFLKRSKSHTPATIAKLQREKEEARAERKQRLSNALRQKNLAATNAASAAAANSSYASGGGGGTVSSRNNKIVVTMIENGGLPIVATSKAERPKAKESASSSDKARNSR
Protein: Replication protein A subunit (Q7TP21)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
Interaction partners:
- RecQ-like DNA helicase BLM
- RecQ-mediated genome instability protein 1
- RNA helicase
- Replication protein A 32 kDa subunit
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- Replication protein A 14 kDa subunit
- DNA repair protein RAD52 homolog
- DNA topoisomerase
- DNA replication ATP-dependent helicase/nuclease DNA2
- Claspin
Sequence:
MQQGDTSIKPVLQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNALVEGGQLASNCVCQVHRFIVNTLKDGRRVVILMDLEVVKSAGEVGVKIGNPVPYNEGHAQQQAVSAPASAATPPASKPQPQNGSLGVGSTVAKAYGASKPFGKPAGTGLLQPTSGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSIELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFSAVKNDYEMTFNNETSVLPCEDGHHLPTVQFDFTGIGDLESKSKDSLVDIIGICKSYEDATKITVKSNNREVAKRNICLMDMSGKVVTATLWGEDADKFDGSRQPVMAIKGARVSDFGGRSLSVLSSSTVLVNPDIPEAYKLRGWHYVFGDGGLKALLHRQAHDPLMNLESQRKQLELKCCVLTLIPPGRQGFNSCVLESSAESISGLRCGQLMWGFDSEGQALDGVSISDLRSGGTGGSNTNWKTLYEAKSENLGQGDKADYFSTVATVVFLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDREFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNTVYLGELKEKVGCVFVSMNEQAFEEVFQNANFRSFTFRIRVKLETYNDESRIKATVIDVKPVDYRDYSKRLIMNIRKNI
Protein: Afadin, adherens junction formation factor (F8W9I4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDS
Protein: Homeobox protein knotted-1-like 1 (Protein BREVIPEDICELLUS) (Protein KNAT1) (P46639)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in meristem function, and may be involved in maintaining cells in an undifferentiated, meristematic state, and its expression disappears at the same time the shoot apex undergoes the transition from vegetative to reproductive development. Positive regulator of LATERAL ORGAN BOUNDARIES (LOB). Probably binds to the DNA sequence 5'-TGAC-3'. Able to traffic from the L1 to the L2/L3 layers of the meristem, presumably through plasmodesmata.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein KNATM
- Transcription factor AS1
- BEL1-like homeodomain protein 9
- Protein ASYMMETRIC LEAVES 2
- Homeobox protein BEL1 homolog
- BEL1-like homeodomain protein 7
- Protein WUSCHEL
- Regulatory protein NPR5
- Receptor-like protein kinase 5
- LRR receptor-like serine/threonine-protein kinase HSL2
Sequence:
MEEYQHDNSTTPQRVSFLYSPISSSNKNDNTSDTNNNNNNNNSSNYGPGYNNTNNNNHHHQHMLFPHMSSLLPQTTENCFRSDHDQPNNNNNPSVKSEASSSRINHYSMLMRAIHNTQEANNNNNDNVSDVEAMKAKIIAHPHYSTLLQAYLDCQKIGAPPDVVDRITAARQDFEARQQRSTPSVSASSRDPELDQFMEAYCDMLVKYREELTRPIQEAMEFIRRIESQLSMLCQSPIHILNNPDGKSDNMGSSDEEQENNSGGETELPEIDPRAEDRELKNHLLKKYSGYLSSLKQELSKKKKKGKLPKEARQKLLTWWELHYKWPYPSESEKVALAESTGLDQKQINNWFINQRKRHWKPSEDMQFMVMDGLQHPHHAALYMDGHYMGDGPYRLGP
Protein: Bile salt hydrolase (I3QNT6)
Organism: Bifidobacterium pseudocatenulatum
Interaction partners:
Sequence:
SDNEGNMYFGRNLDWSFSYGETILVTPRGYRYDYAYGAKGKSEPNAVIGVGVVMADRPMYFDCANEHGLAIAGLNFPGYASFAHEPVEGTENVATFEFPLWVARNFDSVDEVEEALKDVTLVSQVVPGQQESLLHWFIGDGTRSIVIEQMADGMHVHHDDV
Protein: Mediator of RNA polymerase II transcription subunit 15 (Mediator complex subunit 15) (C9JZV5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU364148}.
Interaction partners:
Sequence:
MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVST
Protein: Accessory factor US11 (Vmw21) (P04487)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: Plays a role in the inhibition of host immune response. Participates in the inhibition of host autophagy by interacting with and inhibiting host PKR/EIF2AK2. This interaction also prevents the interferon-induced shut down of protein synthesis following viral infection. Downmodulates the host RLR signaling pathway via direct interaction with host RIGI and IFIH1. Associates with endogenous HSP90 to disrupt the HSP90-TBK1 complex and induces destabilization of host TBK1 through a proteasome-dependent pathway. May also participate in nuclear egress of viral particles through interactions with host NCL and regulation of the viral UL34 mRNA.
Subcellular location: Host nucleus, host nucleolus {ECO:0000269|PubMed:20633584}. Host cytoplasm {ECO:0000269|PubMed:20633584}. Note=Following infection, it is released into the cell cytoplasm.
Interaction partners:
Sequence:
MSQTQPPAPVGPGDPDVYLKGVPSAGMHPRGVHAPRGHPRMISGPPQRGDNDQAAGQCGDSGLLRVGADTTISKPSEAVRPPTIPRTPRVPREPRVPRPPREPREPRVPRAPRDPRVPRDPRDPRQPRSPREPRSPREPRSPREPRTPRTPREPRTARGSV