wanglab/gogpt-training-data huggingface dataset:
Protein: N-acetyltransferase 8 (EC 2.3.1.-) (Acetyltransferase 2) (ATase2) (Camello-like protein 1) (Cysteinyl-conjugate N-acetyltransferase) (CCNAT) (EC 2.3.1.80) (Q9UHE5)
Organism: Homo sapiens (Human)
Function: Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons.
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Interaction partners:
- Aminopeptidase N
- Cytosol aminopeptidase
- N-alpha-acetyltransferase 35, NatC auxiliary subunit
- Beta-secretase 1
- Histone acetyltransferase KAT2A
Sequence:
MAPCHIRKYQESDRQWVVGLLSRGMAEHAPATFRQLLKLPRTLILLLGGPLALLLVSGSWLLALVFSISLFPALWFLAKKPWTEYVDMTLCTDMSDITKSYLSERGSCFWVAESEEKVVGMVGALPVDDPTLREKRLQLFHLFVDSEHRRQGIAKALVRTVLQFARDQGYSEVILDTGTIQLSAMALYQSMGFKKTGQSFFCVWARLVALHTVHFIYHLPSSKVGSL
Protein: Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (Mediator complex subunit 27) (B2RZ56)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 29
- Mediator of RNA polymerase II transcription subunit 15
- Mediator complex subunit 12
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 24
Sequence:
MADVLSVGVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAVLLVTLGKVLKVIVVMRSLFIDRTIVKGYNESVYTEDGKLDIWSKSSYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ
Protein: Probable WRKY transcription factor 4 (WRKY DNA-binding protein 4) (Q9XI90)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Has a positive role in resistance to necrotrophic pathogens (e.g. Botrytis cinerea), but a negative effect on plant resistance to biotrophic pathogens (e.g. Pseudomonas syringae).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223, ECO:0000269|PubMed:18570649}.
Interaction partners:
Sequence:
MSEKEEAPSTSKSTGAPSRPTLSLPPRPFSEMFFNGGVGFSPGPMTLVSNMFPDSDEFRSFSQLLAGAMSSPATAAAAAAAATASDYQRLGEGTNSSSGDVDPRFKQNRPTGLMISQSQSPSMFTVPPGLSPAMLLDSPSFLGLFSPVQGSYGMTHQQALAQVTAQAVQANANMQPQTEYPPPSQVQSFSSGQAQIPTSAPLPAQRETSDVTIIEHRSQQPLNVDKPADDGYNWRKYGQKQVKGSEFPRSYYKCTNPGCPVKKKVERSLDGQVTEIIYKGQHNHEPPQNTKRGNKDNTANINGSSINNNRGSSELGASQFQTNSSNKTKREQHEAVSQATTTEHLSEASDGEEVGNGETDVREKDENEPDPKRRSTEVRISEPAPAASHRTVTEPRIIVQTTSEVDLLDDGYRWRKYGQKVVKGNPYPRSYYKCTTPGCGVRKHVERAATDPKAVVTTYEGKHNHDLPAAKSSSHAAAAAQLRPDNRPGGLANLNQQQQQQPVARLRLKEEQTT
Protein: POC1 centriolar protein homolog (Proteome of centrioles 1) (Q9VU65)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an important role in centriole formation.
Interaction partners:
- Centrosomal protein 135kDa, isoform B
- Spindle assembly abnormal 4
- Serine/threonine-protein kinase PLK4
- Anastral spindle 1, isoform A
- Centriolar coiled coil protein 110kDa, isoform B
- Spindle assembly abnormal protein 6 homolog
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Retinoblastoma-binding protein 5 homolog
- Histone-lysine N-methyltransferase SETD1
- LD02225p
Sequence:
MQGLFRDPALERHFTGHSGGITQLRFGPDGAQIATSSTDSTVILWNLNQAARCIRFASHSAPVNGVAWSPKGNLVASAGHDRTVKIWEPKLRGVSGEFVAHSKAVRSVDFDSTGHLMLTASDDKSAKIWRVARRQFVSSFAQQNNWVRSAKFSPNGKLVATASDDKSVRIYDVDSGECVRTFTEERAAPRQLAWHPWGNMLAVALGCNRIKIFDVSGSQLLQLYVVHSAPVNDVAFHPSGHFLLSGSDDRTIRILDLLEGRPIYTLTGHTDAVNAVAFSRDGDKFATGGSDRQLLVWQSNLHTYDASQFEAKSALASSSCESSGVSSKQSEGSSTSKSNDLSIRIDPRQSLAYQLSEENFQVLDSKHSTQPEKVLGHGMDFKQHSSSPRFF
Protein: EF-hand domain-containing protein (Q38AU8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSLRLGQPTSEQRNRRVFLRFTPIVNEGTEEGKLSSSLSTTTMTSNTSLVEEQSRNIATNVDSTPKSSMPPLPIPEKIGSKSNTPQGLLSPHKVMKEEAGAMQSPDNIRSPGNRKKKNDESPVRLSTDSLTQQESMHLGTIYTRYASFSPKEGCLVNLLNDVTGAGSVSECDVWLYQLENVLGVPRRELCGGTLGIRPESSESPKQQSYGPRRMLTYGEVLRFATWLKSAHKMRIGPRHASLPSNSTPVKGAGKAADDTPSKTATHSGREVKKLDGIKRPKESAKFNIGSGKGKRDSGPSRLFTPTTGSSEVHMPSIGKRPGSTSVSTTTRGYNLELQSFAELGGGSDGTGTIRLIDLKRMLQSFSIEATFGTCVGRVIDKNNTGCITFEEFLWVLEFGVRGMGPAAAIHDHLAAPLTPQNVVTPPVSTERSPASGNKGRSTKPSPSKKGRLAATLEAIRKSFAAQSEKLSPYLTSLKTERRSRSGRRSPNNLRKDRRKLSISPCRGLLTRSTPGRRCSSRKKSRGRSPTNRGTGKRLHTARKDVALGA
Protein: Uncharacterized protein (Q583V6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIHRSLRSSYFSIHVTKPQRVLLMGYRQCASSAAAPLINAKGAGVSPQKDEVRSTCQELRRVMASLLEDRQCLYRDAVLSAALDPYRSKLQSLLEGNDSFGGSTETPKSLTLGKLLECRDGWAAQVGGDAISLVDFYNAFLLSALVNSHADVQLVLDCMQQHDHMDPTAETYVTIMHSFTAQRKGPNPVAGDTAFHYFGHALKTRGEGFITPELWSAVFVVCAVTGAAGKLLDQWWELLLKTCKEGSSPLPYGAVHAALTWCSSKGDVERVMRYFNTANSNSMVAFDQNDVPHVIGSGSLTTRSSDQVVQQCQLRLLVKLMVTAKAIELDGGLRALVVKDVRRLIDPEVLRAAPWGIINDLLSGLSLQSAMQLLKFRSAAALEKDGAVPFTLWASLLRRCARDHHIDQAESLFLFIRKRFELSGEQKAELVEIMIRMFATLPQGDFASATSLFIEHVIRHPPGEPRVEPNATFYNLLIRAADTRNAAMMTFLEACAAGIDMNIETFEALCRSNRFGTISSLSKKLPHGYQASKLDQQIRIPADADAHLRREEAMRLRGKPLVDSTGEVD
Protein: Synaptophysin (Major synaptic vesicle protein p38) (P08247)
Organism: Homo sapiens (Human)
Function: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:18662323}; Multi-pass membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000269|PubMed:18662323}.
Interaction partners:
- Vesicle-associated membrane protein 2
- Ras-related protein Rab-3A
- Synapsin-1
- Synaptosomal-associated protein 25
- Synaptic vesicle glycoprotein 2A
- Synaptotagmin-1
- Chromogranin-A
- Amyloid-beta precursor protein
- Syntaxin-1A
- Gamma-enolase
Sequence:
MLLLADMDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTESDLSIEVEFEYPFRLHQVYFDAPTCRGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPVCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPAGSGGSGYGPQGDYGQQGYGPQGAPTSFSNQM
Protein: Syntrophin, beta 1 (A0A8I6GLN6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
Sequence:
MAVAAAAAAVAAPAGGGGARAQRSGLLEVLVRDRWHKVLVNLSEDALVLSCEEGATAYNGIGTTTNGSFCRGSGTGHPGTGVPQAPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGSGSADPLSSQPFSFHRDRKSIPLKMCYVTRSMTLADPENRQLEIHSPDAKHTVVLRSKDSATAQAWFSAIHSNVGDLLVRVVADIREQLGKTGIAGSREIRHLGWLAEKVPGESEKQWKPALVVLTEKDLLIYDSMPRRKEAWLSPVHSYPLLATRLVHSGPGKGSPQAAMDLSFATRTGTKQGIETHLFRAEISRDLSHWTRSIVQGCHNSAELTAEITTACTYRNQECRLTIHYDNGFSISTEPQDGAFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKEGEIVSVLL
Protein: Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) (P78364)
Organism: Homo sapiens (Human)
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:21282530, ECO:0000269|PubMed:9121482}.
Interaction partners:
- Chromobox protein homolog 2
- E3 ubiquitin-protein ligase RING1
- E3 ubiquitin-protein ligase RING2
- Polycomb group RING finger protein 2
- Polycomb complex protein BMI-1
- E3 SUMO-protein ligase CBX4
- Polycomb complex protein BMI-1
- Polyhomeotic-like protein 2
- Chromobox protein homolog 8
- Polyhomeotic-like protein 3
Sequence:
METESEQNSNSTNGSSSSGGSSRPQIAQMSLYERQAVQALQALQRQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAASRQASSPNTSTTQQQTTTTQASINLATTSAAQLISRSQSVSSPSATTLTQSVLLGNTTSPPLNQSQAQMYLRPQLGNLLQVNRTLGRNVPLASQLILMPNGAVAAVQQEVPSAQSPGVHADADQVQNLAVRNQQASAQGPQMQGSTQKAIPPGASPVSSLSQASSQALAVAQASSGATNQSLNLSQAGGGSGNSIPGSMGPGGGGQAHGGLGQLPSSGMGGGSCPRKGTGVVQPLPAAQTVTVSQGSQTEAESAAAKKAEADGSGQQNVGMNLTRTATPAPSQTLISSATYTQIQPHSLIQQQQQIHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQQQQQQQQQQQQQPQATTLTAPQPPQVPPTQQVPPSQSQQQAQTLVVQPMLQSSPLSLPPDAAPKPPIPIQSKPPVAPIKPPQLGAAKMSAAQQPPPHIPVQVVGTRQPGTAQAQALGLAQLAAAVPTSRGMPGTVQSGQAHLASSPPSSQAPGALQECPPTLAPGMTLAPVQGTAHVVKGGATTSSPVVAQVPAAFYMQSVHLPGKPQTLAVKRKADSEEERDDVSTLGSMLPAKASPVAESPKVMDEKSSLGEKAESVANVNANTPSSELVALTPAPSVPPPTLAMVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQLLKESEKPLQTGLPTGLTENQSGGPLGVDSPSAELDKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEFQEANYARVRRRGPRRSSSDIARAKIQGKCHRGQEDSSRGSDNSSYDEALSPTSPGPLSVRAGHGERDLGNPNTAPPTPELHGINPVFLSSNPSRWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINVLKET
Protein: Sex-determining transformer protein 2 (G8JY28)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MFESEVRHYLHRDLRGSTTAVRVYNLVQKQRLASSLDEPQVELDEFSIKRSSPPCRYYAPPPKYSCKKRSRSSDEDEDSDPNQPGPSNRRSPKTGNKRVRGNGDNTELYIPNRYELIVSGKSVGGNTSAAWNGPGSTLEQNMNALEECFELGVDEYDFDEHDGDEGCELVQDMLDRERNLMNKRSTAQRRESRNIEKMKKSQENLDKEKSEEKISESKKNQDDSIESPNLPGTPANLPVDEPLPPVGRLYIVEHVLPEEYRRDPLTEPPSMEDCIRAHSDPNLPPHPRADQYPASFTRPMVEYCEDIYWTHRTGQLPPGLQVPRRPYDYYHITERTPPPEDLNWVPPAESPPIPIPQQAFDLLEERRRNHREQQDEAREGDLSDPEV
Protein: ClpXP adapter protein SpxH (O31606)
Organism: Bacillus subtilis (strain 168)
Function: Adapter protein required for efficient degradation of Spx by ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx and exposes the C-terminus of Spx for recognition and proteolysis by ClpXP. Is specific for Spx and does not enhance proteolysis by ClpCP protease. Probably binds 2 zinc ions.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02245, ECO:0000269|PubMed:25353645}. Note=Soluble under non-stress conditions and aggregates in response to stress conditions such as disulfide stress, heat and ethanol. {ECO:0000269|PubMed:25353645}.
Interaction partners:
- Group 2 truncated hemoglobin YjbI
- Global transcriptional regulator Spx
- Adapter protein MecA 1
- ATP-dependent Clp protease ATP-binding subunit ClpX
- Adapter protein MecA 2
- Thioredoxin reductase
- UPF0354 protein YtpQ
- Thioredoxin
- TPR repeat-containing protein YsoA
- Putative 8-oxo-dGTP diphosphatase YtkD
Sequence:
MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKLKIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLSSPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEFKKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEILFEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKVEAKHGMFWKSLSTYSDEYQSCEK
Protein: At4g38410 (Dehydrin family protein) (Putative cold-regulated protein) (Q8GY17)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Dehydrin family protein
- Probable dehydrin LEA
- Dehydrin Xero 1
- Dehydrin HIRD11
- Dehydrin Rab18
- Esterase/lipase/thioesterase family protein
- Dehydrin Xero 2
- 1,4-dihydroxy-2-naphthoyl-CoA synthase, peroxisomal
- RING-H2 finger protein ATL18
Sequence:
MADHPRSTEQQEADAAASKGCGMFDFLKKKPEDVHSSENARVTKEPKEEEKPSLAERFHLSDSSSSDEEAGENGEKKEKKKKKKKNEVAEDQCETEEKIPAGIGHEDGKEKGFMEKIKDKLPGGHNGKPEAEPHNDKAKEKGFMEKIKEKLPGHTNDEKKKET
Protein: Ornithine decarboxylase antizyme 3 (H0Y7Y4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRPEGGPRRRRQERPPPVLPAARRITYKEEEDLTLQPRSCLQCSESLVGLQEGKSTEQGNHDQLKELYSAGNLTVLATDPLLHQDPVQLDFHFRLTSQTSAHWHGLLCDRRLFLDIPYQALDQGNRESLTATLEYVEEKTNVDSVFVNFQNDRNDRGALLRAFSYMGFEVVRPDHPALPPLDNVIFMVYPLERDVGHLPSEPP
Protein: BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) (Q9UHR4)
Organism: Homo sapiens (Human)
Function: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19366662}. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Interaction partners:
- Actin nucleation-promoting factor WASL
- Cell division control protein 42 homolog
- Dol-P-Man:Man
- Dol-P-Man:Man
- BAR/IMD domain-containing adapter protein 2
- Dolichyl-phosphate beta-glucosyltransferase
- Epidermal growth factor receptor kinase substrate 8
- Actin nucleation-promoting factor WAS
- Actin-binding protein WASF2
Sequence:
MSRGPEEVNRLTESTYRNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPSLQRSVSVATGLNMMKKQKVKTIFPHTAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYLECLSMGAAADRRADSARTTSTFKAPASKPETAAPNDANGTAKPPFLSGENPFATVKLRPTVTNDRSAPIIR
Protein: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) (P13086)
Organism: Rattus norvegicus (Rat)
Function: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03222}.
Interaction partners:
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Sequence:
MTAAVVAAAATATMVSGSSGLAAARLLSRTFLLQQNGIRHGSYTASRKNIYIDKNTKVICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGKKHLGLPVFNTVKEAKEKTGATASVIYVPPPFAAAAINEAIDAEIPLVVCITEGIPQQDMVRVKHKLTRQGKTRLIGPNCPGIINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCIGIGGDPFNGTNFIDCLDVFLKDPATEGIVLIGEIGGHAEENAAEFLKEHNSGPKAKPVVSFIAGITAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVIVSMSPAQLGTCMYKEFEKRKML
Protein: MADS-box transcription factor 5 (FDRMADS2) (OsMADS5) (Q0DEB8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor. May be involved in the control of flowering time.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGRGKVELKRIENKISRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSTRGRLFEFSTSSCMYKTLERYRSCNYNLNSCEASAALETELSNYQEYLKLKTRVEFLQTTQRNLLGEDLVPLSLKELEQLENQIEISLMNIRSSKNQQLLDQVFELKRKEQQLQDANKDLKRKIQETSGENMLHISCQDVGPSGHASEANQEFLHHAICDPSLHIGYQAYMDHLNQ
Protein: Spastin (EC 5.6.1.1) (Q6NW58)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.
Subcellular location: Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03021}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03021}. Note=Forms an intramembrane hairpin-like structure in the membrane. {ECO:0000255|HAMAP-Rule:MF_03021}.
Interaction partners:
- IST1 homolog
- Atlastin-1
- Charged multivesicular body protein 1b
- Receptor expression-enhancing protein.
- Atlastin GTPase 2.
- SPG11 vesicle-trafficking-associated, spatacsin.
- Spartin
- Atlastin 3
- Protrudin
- UBX domain protein 7.
Sequence:
MNSGHKARLRGGRACGPVSDGSARGNRLLFYTRSLSRVPEWLLRVLLLLLRWLFQPIRRAMAARAKECGPDGSEETGERIRNYHKQAFEFISVALQIDEDEKGDKQKAVQWYRKGIAELEKGIQIQVTGAGEKADRARKLQDKMITNLSMAEDRLKLLGNLLSQSPAESSSDDSFYSFSNGNLRPAPASGAVSKKKDTLTITNQTSLRPKNPPKSTPNASGLNCTPSAAQSSRTGPQNNQKGPTVKGKNNVKASTTATASPQRKRDMKNFKNVDSKLASLILNEIVDSGSVVRFDDIAGQDLAKQALQEIVILPALRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAMESNATFFNISAATLTSKYVGEGEKLVRALFAVARELQPSIIFIDEIDSLLCERREGEHDASRRLKTEFLIEFDGVQSGGDERVLVMGATNRPQELDEAVLRRFAKRIYVALPTEETRLKLLKNLLSKHRNPLSQKELSQLARLTDGYSGSDLTSLAKDAALGPIRELKPEQVRNMSAHEMRDIRISDFLESLKRIKRSVSPQTLDQYVRWNREYGDTTGV
Protein: Alginate biosynthesis protein AlgZ/FimS (G3XCZ2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Positive alginate biosynthesis regulatory protein
- RNA polymerase sigma-H factor
- GDP-mannose 6-dehydrogenase
- Transcription factor AmrZ
- D-ribose/D-allose-binding protein
- Alginate biosynthesis transcriptional regulatory protein AlgB
- Porphobilinogen deaminase
- Phosphomannomutase/phosphoglucomutase
- Protein PilJ
Sequence:
MPIRFKPGRSTRPAVQDDFFIPELCEAEALFTLVLLAELLVLVLVLAEPMTPSFNWVRLALASLFVQWIVLLSAALFCRLRPLLARLPVALAGSACCLLVVALTLGCTAVAEHYQLGGELTRAGEVNLYLRHALIALIMSALVLRYFYLQSQWRRQQQAELQARLESLQARIRPHFLFNSLNSIASLIELDPLKAEHAVLDLSDLFRASLAKPGTLVSWEEELALARRYLSIEQYRLGDRLQLDWQVHGVPANLPIPQLTLQPLLENALIYGIQPRVEGGLVQVEAVYREGVFQLCVSNPYDEALESPPSKGTRQALHNIDARLGALFGPKASLSVERRDGRHYTCLRYPCARLMQEA
Protein: Ecm29 proteasome adaptor and scaffold (R4GMY1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAAAASASQDELNQLERVFLRLGHAETDEQLQNIISKFLPPVLLKLSSTQEGVRKKVMELLVHLNKRIKSRPKIQLPVETLLVQYQDPAAVSFVTNFTIIYVKMGYPRLPVEKQCELAPTLLTAMEGKPQPQQDSLMHLLIPTLFHMKYPVESSKSASPFNLAEKPKTVQLLLDFMLDVLLMPYGYVLNESQSRQNSSSAQGSSSNSGGGSGIPQPPPGMSFYAAKRVIGDNPWTPEQLEQCKLGIVKFIEAEQVPELEAVLHLVIASSDTRHSVATAADLELKSKQSLIDWNNPAIINKMYKVYLGDIPLKTKEGAVLKPELKRDPVSTRVKLKIVPHLLRSRQAAETFPANIQVVYDGLFGTNTNSKLRTLSLQFVHHICITCPEIKIKPLGPMLLNGLTKLINEYKEDPKLLSMAYSAVGKLSSRMPHLFTKDIALVQQLFEALCKEEPETRLAIQEALSMMVGAYSTLEGAQRTLMEALVASYLIKPEVQVRQVAVKFASTVFPSDHIPSRYLLLLAAGDPREEVHGEAQRVLRCLPGRNRKESTSEQMPSFPEMVYYIQEKASHRMKTPVKYMTGTTVLPFNPAAFGEIVLYLRMCLAHSAGVVPTSQSLADMQDHAPAIGRYIRTLMSSGQMAPSSSNKSGETNPVQIYIGLLQQLLAGVGGLPVMYCLLEAVSVYPEKLATKFVDKTEWIKSLMNNSKEEMRELAALFYSVVVSTVSGNELKSMIEQLIKTTKDNHSPEIQHGSLLALGFTVGRYLAKKKMRMSEQQDLERNADTLPDQEELIQSATETIGSFLDSTSPLLAIAACTALGEIGRNGPLPIPSEGSGFTKLHLVESLLSRIPSSKETNKMKERAIQTLGYFPVGDGDFPHQKLLLQGLMDSVE
Protein: Kelch-like protein 4 (Q9C0H6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- CPX chromosomal region candidate gene 1 protein
Sequence:
MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEACEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP
Protein: C-C motif chemokine 5 (MuRantes) (SIS-delta) (Small-inducible cytokine A5) (T-cell-specific protein RANTES) (P30882)
Organism: Mus musculus (Mouse)
Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Subcellular location: Secreted.
Interaction partners:
- Platelet factor 4
- C-C motif chemokine
- C-C chemokine receptor type 2
- C-C chemokine receptor type 5
- Probable C-C chemokine receptor type 3
- C-C chemokine receptor type 1
- C-X-C chemokine receptor type 4
- C-X-C motif chemokine 10
- C-X-C motif chemokine 9
- C-X-C chemokine receptor type 3
Sequence:
MKISAAALTIILTAAALCTPAPASPYGSDTTPCCFAYLSLALPRAHVKEYFYTSSKCSNLAVVFVTRRNRQVCANPEKKWVQEYINYLEMS
Protein: Cytochrome P450 71B19 (EC 1.14.-.-) (Q9LTM4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- UDP-glycosyltransferase 91A1
- UDP-glycosyltransferase 91C1
- UDP-glycosyltransferase 73B4
- UDP-glycosyltransferase 76B1
Sequence:
MAISFLCVFLITFVSLIFFAKKIKRSKWNLPPSPPKFPVIGNLHQIGELPHRSLQHLAERYGPVMLLHFGFVPITVVSSREAAEEVLRTHDLDCCSRPKLVGTRLLSRDFKDIGFTPYGNEWKARRKFALRELFCLKKVQSFRHIREEECNFLVKQLSESAVDRSPVDLSKSLFWLTASILFRVALGQNFHESDFIDKEKIEELVFEAETALASFTCSDFFPVAGLGWLVDWFSGQHKRLNDVFYKLDALFQHVIDDHLNPGRSKEHEDIIDSMLDVIHKQGEDSSLELTIDHIKGFLANIFLAGIDTGAITMIWAVTELVKNPKLIKKVQGDIREQLGSNKERITEEDIEKVPYLKMVIKETFRLHPAAPLILPRETMAHIKVQGYDIPPKRRILVNVSAIGRDPKLWTNPKEFDPERFMDSFVDYRGQHYELLPFGSGRRICPGMPMGIAAVELGLLNLLYFFDWKLPDGMTHKDIDTEEAGTLTIVKKVPLKLVPVRVQ