wanglab/gogpt-training-data huggingface dataset:
Protein: Vacuolar protein sorting-associated protein 30 (Autophagy-related protein 6) (Q02948)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Also plays a role in regulation of filamentous growth.
Subcellular location: Endosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Preautophagosomal structure membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein. Note=With the VPS34 PI3-kinase complex I, localizes to the vacuole-isolation membrane contact site (VICS) during isolation membrane (IM) expansion. The IM is a membrane sac generated from the pre-autophagosomal structure that ultimately expands to become a mature autophagosome.
Interaction partners:
- Autophagy-related protein 14
- PtdIns3K complex I subunit atg38
- Phosphatidylinositol 3-kinase VPS34
- Vacuolar protein sorting-associated protein 38
- Serine/threonine-protein kinase ATG1
- Serine/threonine-protein kinase VPS15
- Putative lipase ATG15
- Autophagy-related protein 18
- Ubiquitin-like protein ATG12
- Autophagy-related protein 9
Sequence:
MKCQTCHLPLQLDPSLEGLSLTQRNLLLSNNSIITATNENVISNKGIEAADNCGPQIPKERLRRLGEIQNIKDLNLKDDKLITDSFVFLNHDDDDNANITSNSREDQRYGNANGNDNKKANSDTSDGTSTFRDHDEEEQEATDEDENQQIQLNSKTLSTQVNAMTNVFNILSSQTNIDFPICQDCCNILINRLKSEYDDAIKERDTYAQFLSKLESQNKEISESNKEKQYSHNLSEKENLKKEEERLLDQLLRLEMTDDDLDGELVRLQEKKVQLENEKLQKLSDQNLMDLNNIQFNKNLQSLKLQYELSLNQLDKLRKINIFNATFKISHSGPFATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKINLVDYELQPMGSFSKIKKRMVNSVEYNNSTTNAPGDWLILPVYYDENFNLGRIFRKETKFDKSLETTLEIISEITRQLSTIASSYSSQTLTTSQDESSMNNANDVENSTSILELPYIMNKDKINGLSVKLHGSSPNLEWTTAMKFLLTNVKWLLAFSSNLLSKSITLSPTVNYNDKTISGN
Protein: Protein NDL2 (Protein N-MYC DOWNREGULATED-LIKE 2) (Q9ASU8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in a signaling pathway that modulates root auxin transport and auxin gradients. Acts partially by positively regulating the auxin carrier PIN2 and AUX1. Acts, together with GB1 as positive regulator of meristem initiation and branching. GB1 and NDL2 positively regulate basipetal inflorescence auxin transport and modulate MAX2 expression in shoots, which regulates organ and lateral meristem formation by the establishment and maintenance of auxin gradients.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9FJT7}.
Interaction partners:
- Guanine nucleotide-binding protein subunit gamma 2
- Guanine nucleotide-binding protein subunit gamma 1
- Transmembrane protein
- INCREASED PETAL GROWTH ANISOTROPY 1-like protein 1
- Expressed protein
- Small ribosomal subunit protein eS27y
- Regulator of G-protein signaling 1
- Guanine nucleotide-binding protein subunit beta
Sequence:
MADSSDSVSIDMEALSLGGQEHLVETTYGPVCVAVCGDPDKPALITYPDIALNYMFCFQGLLFCPEASSLLLHNFCIYHISPLGHELGAPMISVDAPLLSADDLADQIVEVLNYFGLGAVMCMGVTAGAYILTLFAMKYRQRVLGLILVSPLCQAPSWSEWLCNKVMSNLLYYYGTCGVVKEMLLKRYFSKEVRGNGHVPESDIVQECRRLLSERQSTNVWRFLEAINGRVDLSEGLRKLQCRTLIFIGENSAYHSEAVHMTTKLDRRYGALVEVQGSGSLVSEEQPQAMIIPMEYFLMGYGLYRPTQSVSPRSPLSPTRISPELLSPENMGLKLKPIKTRLAL
Protein: Oligoribonuclease, mitochondrial (EC 3.1.15.-) (P54964)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:9933355}.
Interaction partners:
- RNA exonuclease 3
- RNA exonuclease 1
- Exosome complex exonuclease RRP6
- RNA exonuclease NGL2
- RNA exonuclease 4
- Mitochondrial escape protein 2
- Ribonuclease Z
Sequence:
MKWLLFPARIVARTRPNLFSLYRRSVSQYLRPRTIQNLQSMAQTPELKTKLFKPLVWIDCEMTGLDHVNDRIIEICCIITDGHLAPVKAADGQGDSHYESVIHYGPEVMNKMNEWCIEHHGNSGLTAKVLASEKTLAQVEDELLEYIQRYIPDKNVGVLAGNSVHMDRLFMVREFPKVIDHLFYRIVDVSSIMEVARRHNPALQARNPKKEAAHTAYSDIKESIAQLQWYMDNYLKPPQETESVESIGSEQPESPSSSTSSLKRQRTDF
Protein: 2-methylcitrate synthase, mitochondrial (Methylcitrate synthase) (EC 2.3.3.5) ((2S,3S)-2-methylcitrate synthase) (Citrate synthase 1) (EC 2.3.3.16) (Q50I20)
Organism: Aspergillus fumigatus (Neosartorya fumigata)
Function: Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. May play a role in virulence.
Subcellular location: Mitochondrion matrix {ECO:0000305}.
Interaction partners:
Sequence:
MAMTMRSTRHASKLAQTARLALTNSRRYSTAEPDLKTALKAVIPAKRELFKQVKERSDEVIGEVKVANVIGGMRGLKSMLWEGSVLDPEEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLTGQVPSTNQVRAFSRELAEQSHLPQHILDLIKSFPRSMHPMTQLSIAVAALNTESKFAKAYEKGLSKADYWEPTFDDSISLLAKIPRVAALVFRPDEVDQVGTQALDASQDWSYNFAELLGKGGKENQDFHDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQDKIGTKFTDDDVRNYLWDTLKSGRVVPGYGHGVLRKPDPRFQALMDFAATRPDVLANPVFQLVKKNSEIAPAVLTEHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVTFGVSRALGPLVQLIWDRALGLPIERPKSINLLGLKK
Protein: Serpin 38F, isoform A (Q9VII7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Serpin 28F
- Accessory gland-specific peptide 26Aa
- ACP53C14A
- glutaminyl-peptide cyclotransferase
- Accessory gland protein Acp36DE
- GH21475p
- Accessory gland-specific peptide 26Ab
- Accessory gland protein Acp76A
- Accessory gland protein Acp53Ea
- Accessory gland protein Acp29AB
Sequence:
MKYLCLLLLATSVSCRFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKLPDDKKEVAAKFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKITASIVNKWVDTQTSGKIRDLVMPSDVANLVLVILNAIYFKGQWQKKFNTEQTKSDFHISDQKSVPVQMMSLVRPFGVSYDRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEKKMVGFTPKLININVHLRLPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVANSGAHVGGVVHKAFLEVNEEGSEAAAATAVVFRYKSIRSPPMDFNVNHPFAYVIRDAENIYFQGHFVNPEL
Protein: Elongation factor family protein (F4IPW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- Large ribosomal subunit protein bL28c
- Ribosomal RNA small subunit methyltransferase, chloroplastic
- 50S ribosomal protein L33
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL18z
- 50S ribosomal protein L20
- Large ribosomal subunit protein bL20c
Sequence:
MAGPLLRSLWSNTTRRSFSSHSSPSKFGYSLSSLRSFSAATASTAAAGAPNSSLDPNRLRNVAVIAHVDHGKTTLMDRLLRQCGADIPHERAMDSINLERERGITISSKVSPFVTSIFWKDNELNMVDTPGHADFGGEVERVVGMVEGAILVVDAGEGPLAQTKFVLAKALKYGLRPILLLNKVDRPSVTEERCDEVESLVFDLFANCGATEEQLDFPVLYASAKEGWASSTYTKDPPVDAKNMADLLDAVVRHVQPPKANLDEPFLMLVSMMEKDFYLGRILTGRVTSGVVRVGDRVNGLRKTDSGSEKIEEAKVVKLMKKKGTTIVSIDAAGAGDIICMAGLTAPSIGHTVASAEVTTALPTVELDPPTISMTFGVNDSPLAGQDGTHLTGGRIGDRLMAEAETNLAINVIPGLSESYEVQGRGELQLGILIENMRREGFELSVSPPKVMYKTEKGQKLEPIEEVTIEINDEHVGLVMEALSHRRAEVIDMGPVPGNEGRTRLSLTCPSRGLVGYRCVFSSDTRGTGFMHRAFLTYEKYRGPLGNVRKGVLVSMARGTITAHSLMSLEARGILFVSPGLDSYDGMIIGEHSRETDLDLNPVKAKELTNIRSAGKDENVKLSPPRLMTLEEAIGYVASDELIEVTPKTIRLRKRCLDVNKRKSQSKRAKD
Protein: Autophagy-related protein 14 (Cytoplasm to vacuole targeting protein 12) (P38270)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS).
Subcellular location: Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=TRS85 is required for the recruitment of ATG14 to the PAS.
Interaction partners:
- Phosphatidylinositol 3-kinase VPS34
- Serine/threonine-protein kinase VPS15
- Vacuolar protein sorting-associated protein 30
- PtdIns3K complex I subunit atg38
- Putative lipase ATG15
- Vacuolar protein sorting-associated protein 38
- Serine/threonine-protein kinase ATG1
- Autophagy-related protein 18
- Autophagy-related protein 13
- Autophagy-related protein 9
Sequence:
MHCPICHHRAHVVYCAHCINTSPSLLLKLKLDLILLKDENKELNGKVEQILNEAMNYDQLDIKRMEKKKDPLMNSLMKLDVLRMKKNNNLIRHRIEQLNERIYSKRNHISELKVEIDNYKCYKVGTGTDKLREQVEISDAKNKLAQVSKICESARDYKLNLLNNWFVIQKLQDNFQIPFAIAFQPLISLKNFRILPLAITNDSINIMWKYISFFSDILMIKLPYTNKICEQPMFEFSDSIQTVVQRLIKLIINILQICRHLKLVPSTPMDIPWLLDQYDVDGLFYNMVKRNKMKCRSVSLYWTFGMLYSMVLDNMNNPQRGHPARRTAPPPTVTGPHDRWYVVG
Protein: Centrin 2 (G3V9W0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- UV excision repair protein RAD23 homolog B
- PCI domain-containing protein 2
- p125
- Germinal-center associated nuclear protein
- Transcription and mRNA export factor ENY2
- RAD23 homolog A, nucleotide excision repair protein.
- SFI1 centrin binding protein
- Serine/threonine-protein kinase PLK1
- Nuclear pore complex protein Nup153
- DNA excision repair protein ERCC-1
Sequence:
MELCSGRASNFKKTNMASSAQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDMKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFSDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNEQEFLRIMKKTSLY
Protein: AT3g23600/MDB19_9 (Alpha/beta-Hydrolases superfamily protein) (Contains similarity to endo-1,3-1,4-beta-D-glucanase) (Q9LUG8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSGPQCCENPPTLNPVSGSGHVEKLGGLDAYVSGSAESKLCVLLISDIFGFEAPNLRALADKVAASGFYVVVPDYFGGDPYNPSNQDRPIPVWIKDHGCDKGFENTKPVLETIKNKGITAIGAAGMCWGAKVVVELSKEELIQAAVLLHPSFVNVDDIKGGKAPIAILGAEIDQMSPPALLKQFEEILSSKPEVNSYVKIHPKVSHGWTVRYNIDEPEAVKAAEEAHKEMLDWFVTYIK
Protein: Amino acid permease 6 (Amino acid transporter AAP6) (P92934)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Amino acid-proton symporter. Stereospecific transporter with a broad specificity for tryptophan, proline, and neutral and acidic amino acids. Has an affinity for aspartate in a physiological range. Involved in the uptake of amino acids diffusing out of the xylem tracheids into the xylem parenchyma.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
- WAT1-related protein At4g01430
- Cationic amino acid transporter 6
- Cationic amino acid transporter 9
- WAT1-related protein At1g01070
- Cationic amino acid transporter 8
- WAT1-related protein At2g39510
Sequence:
MEKKKSMFVEQSFPEHEIGDTNKNFDEDGRDKRTGTWMTGSAHIITAVIGSGVLSLAWAIAQLGWVAGPAVLMAFSFITYFTSTMLADCYRSPDPVTGKRNYTYMEVVRSYLGGRKVQLCGLAQYGNLIGITIGYTITASISMVAVKRSNCFHKNGHNVKCATSNTPFMIIFAIIQIILSQIPNFHNLSWLSILAAVMSFCYASIGVGLSIAKAAGGGEHVRTTLTGVTVGIDVSGAEKIWRTFQAIGDIAFAYAYSTVLIEIQDTLKAGPPSENKAMKRASLVGVSTTTFFYMLCGCVGYAAFGNDAPGNFLTGFGFYEPFWLIDFANVCIAVHLIGAYQVFCQPIFQFVESQSAKRWPDNKFITGEYKIHVPCCGDFSINFLRLVWRTSYVVVTAVVAMIFPFFNDFLGLIGAASFWPLTVYFPIEMHIAQKKIPKFSFTWTWLKILSWTCFIVSLVAAAGSVQGLIQSLKDFKPFQAP
Protein: Lipase member N (EC 3.1.1.13) (EC 3.1.1.3) (Lipase-like abhydrolase domain-containing protein 4) (Q5VXI9)
Organism: Homo sapiens (Human)
Function: Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Proprotein convertase subtilisin/kexin type 5
- Transcription factor Sp6
- Ultra-long-chain fatty acid omega-hydroxylase
- Low-density lipoprotein receptor-related protein 5
- Glucosylceramide transporter ABCA12
- Acrosomal protein SP-10
- Transcription factor Sp9
- Omega-hydroxyceramide transacylase
- MARVEL domain-containing protein 1
- Humanin-like 5
Sequence:
MMWLLLTTTCLICGTLNAGGFLDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPTISFKYPTGIFTRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTKICNNKILWLICSEFMSLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGNDADNMKHYNQSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVARILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSEIIALMKAYS
Protein: Synaptophysin-like 1 (A0A8I6A9E4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
RVSLLPSSAPRPDSFPSFPSEDVHLPDQPQPAQGAARLHQDPRFKGKTEIQVNCLSAPGENKTITATFGYPFRLNQASFHSAPNVNVCKVNWEKHVLIGDYSSSAQFYVTFAVLVFLYCIAALLLYVGYTNLYRDSRKLPMIDFIVTLVATFLWLVSSSAWAKALTDIKVATGHRIVEELDPCKSEVSCYFVSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKETSLHSPSNTSASHGQGGVPPTSGM
Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 5) (B8A552)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Tyrosine-protein kinase BAZ1B
- DNA polymerase epsilon subunit 3
- Histone-binding protein RBBP4
- Remodeling and spacing factor 1 isoform X2
- Bromodomain adjacent to zinc finger domain, 1A.
- Bromodomain adjacent to zinc finger domain, 1A.
- Chromatin accessibility complex subunit 1.
- Bromodomain PHD finger transcription factor
- Histone-binding protein RBBP7
- CECR2 histone acetyl-lysine reader
Sequence:
MSQTESSMEQQREEEPSQLDPAGPAEDDTSENGHDEASDTAMDSEAQSSSPPSAKGKDLLGGYEEKVQTDRTNRFEYLLKQTEVFAHFIQPAAQKTPTSPLKMKPGRPRIKKDEKQNLLSAGDNRHRRTEQEEDEELLSENSKATSVCTRFDDSPSYVKTGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLYNWMNEFKRWVPSLKAVCLIGDREERTAFIRDTLLPGEWDVCVTSYEMLIIERAVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSSEDFDAWFDTNNCLGDTKLVERLHTVLRPFLLRRIKADVEKSLLPKKEIKIYVGLSKMQREWYTKILMKDIDILNSAGKMDKMRLLNVLMQLRKCCNHPYLFDGAEPGPPYTTDLHLVVNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYGYCRLDGQTPHEERQISINAFNEPNSSKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQVDLQAMDRAHRIGQKKQVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDPSMNKLGKDEMLSIIRHGATHVFASKESEITDEDIDGILERGERKTMEMKEKMANLGEGSLRNFTMDTENSVYNFEGEDYREKKKVVTNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPDLPNSAEMQKEEQAKIDEAEPLNEEELEEKENLLSQGFTIWTKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDSKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKESVYDELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEREKAEKKKRGPRTSSAQKRKQDGTPDGRGRKKKLKL
Protein: Two-component response regulator, CopR (Q9I034)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Sensor protein
- Sensor protein
- Sensor protein
- Sensor protein
- Repressor, PtrA
- Copper-resistant cuproprotein CopI
- histidine kinase
- histidine kinase
- Copper resistance protein B
- histidine kinase
Sequence:
MKLLIVEDEPRIGQYLRQGLAEAGFAVDLSDDGNEGEQLALGGDYDLLILDVMLPGRDGWQILRSVRDAGMTVPVLFLTARDAVEDRVRGLEQGADDYLVKPFAFVELLARVRTLLRRGSQQLQETTLQLADLELDLLRRRVQRQGKRIDLTAKEFALLELLLRRSGEVLPKSLIASQVWDMNFDSDTNVIEVAIRRLRAKVDDDYPQRLIHTVRGMGYVLEERDE
Protein: Leucine-rich repeat protein (LRRP) (Q388G1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNVDLSNKSINELNFDAQNSSPEELLAAARVVRLTASHNYISNIVGLGALFHQLTHLDLSHNKLGCNGAGRMSGESDHRTPWLSTLPRSLRVLNLSHNHLRGFSLEYNLGDRSCSDGNESPDTTVVMGVDGGLSRLRGSSPINVALFFNRRLFPHLSELDLSHNDLQQTLEDSDVIEELWHESVELPMSSVSSDAEKAAWVQCTTSAIVVLQLDGNAKLESLNGVLCGMEGLLFLHAAQCGIADLTAVSSAATACPKLRDIDLRGTPLSETFLQAPREAVATFTEILLFPALLASRGGVRRREQRHEDEEETRHGLKELVKEIVQHHLHEMEASVERQQSSAEGNIRNSGGGGLRLVLYASLLHQVLPQVIEIDNGIEVGRMKRLFTEAARDVLQNFIENGNSIEKTRDPMMSPRHYISPPRTLSPVEEKDMTVWRDPTSQLNVDGVAPSEPPQGRSCLGKRGADVARSQLIQSPTTAAVSGHCHLTSPPLPPSPLKSPTDKRRPLLTPKRETFEDRRPLRSPTERDTAVATPDAAEAADSQYNRHSEFVSRGVVPVVSPRSDKRSSDSSKRDYQRVDSLERRTGVNQTGVRRGSSTNKCGGVETMNGILNGSEKLAGKERYCRAFNPLSPTAAAGPPLAPTRDVSNSSSFDDGRSSVRYLQAVASLTPMLEHRLRTSSPLDSPSTVNDHSRQSNDTNEGQSNSSSHQHCNNNFSSASSSTFTTVNSTREKLLQQAQALEQSLIRSQDRQRGLHNTVTELTTQLKQHRQLIKDQRQEAMRLRQERDRLVDVIKTAKRRLEKRQKDVAYGATALKRRETLEQQKAVMQRLVKEKKRLQEQERRLRESMAVSLESDTPVLDSCSRHLSPENGRNRQPPQMKKTRSDLLRENAVRLRMEAAKKEEPLAYDPRKFRRNEHSAINGTEGTLPCDVTPVSLHTDSGKRYDITGSSSNRESTDEACRGVKPSNGREASFSSGGSSWHPRHGSRGPRLPGSLYQQGCDPYAVEDGETRDDSTGKGDEIRNEWLQNMSLQSLFDAAVSMQRQRLLTKQLTRKKISEARDDEHRETCDTSNPPASATELASHHYRAPTGSTGGPALYRTVIEPFHDISTGNLSRSGGGRISVRSGEGSTIGDAVGKGEVSARGDVDSGANSQNSDDDRGLNGADVLSRLVHPQNTEGCISSVSSRADSSSVAEHLSVDACSIYAEILKQQQQQQRLLLQRSQGPQSTERAFPVEMGATYPTTPTKVEGLLQNQKAGYTNQRADNRVTGHSSDDGGSEEYTVSDFAQRPVFI
Protein: Replication protein A C-terminal domain-containing protein (Q95Y97)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Probable replication factor A 73 kDa subunit
- RecQ-like DNA helicase blm-1
- DNA primase large subunit
- DNA topoisomerase 3
- RecQ-mediated genome instability protein 1
- DNA topoisomerase
- DNA polymerase
- DNA polymerase alpha subunit B
- RPA_C domain-containing protein
- Replication factor C subunit 1
Sequence:
MWNETVEHENAGNGWAAGESSFMTDRKPDSKATTLGERLPVPVTISNLIEHFSAQDDKYVVGTFRFATVLTVGIVKDISQDGTTYTYDLCDPNNTEMEYRTLKYDNEGSTFDHSSIVEGTRVRAIGKLKGFDGNNTIMLFNITPVEDDKDFTIFELEAEAARLFFQKNVSEKLKSVDSDGFQGMLAPPKSRMSQTSHQSSQGSDTKERLYAQPQKVMTGANQGDVLRERITAVLMAVPEGSRDEGRHVSWIAEQIQETNISIVRKCVGEMVENGLVYTTVDEETVSAI
Protein: Uncharacterized protein (Q389F0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQAVGETSVSGGWAEDEDYLLGARSCGDGATVPLNIAHVHQSATTQRRREFSEIFSVGNSMRMHSDSPVASSIDTCLIGSSGEERLSPTVADDQRVLECLASIAYLVGSPLQRSQPTAAEPVQKALCVVRKLLQRGVNPEQIINVIESRDGVGGG
Protein: All-trans-retinol dehydrogenase [NAD(+)] ADH7 (EC 1.1.1.105) (Alcohol dehydrogenase class 4 mu/sigma chain) (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Omega-hydroxydecanoate dehydrogenase ADH7) (EC 1.1.1.66) (P41682)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation.
Subcellular location: Cytoplasm.
Interaction partners:
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Aldehyde dehydrogenase X, mitochondrial
- Aldehyde dehydrogenase family 3 member A2
- 4-trimethylaminobutyraldehyde dehydrogenase
- Alpha-aminoadipic semialdehyde dehydrogenase
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase 1A1
- Aldehyde dehydrogenase, mitochondrial
- Aldehyde dehydrogenase family 3 member B1
- Retinaldehyde dehydrogenase 3
Sequence:
MDTAGKVIKCKAAVLWGTNQPFSIEDIEVAPPKAKEVRVKILATGICGTDDHVIKGTMVSKFPVIVGHEAVGIVESVGEEVTTVRPGDKVIPLFLPQCRECNPCRNPEGNLCIRSDLTGRGVLADGTTRFTCKGKPVQHFMNTSTFTEYTVLDESSVAKIDAEAPPEKACLIGCGFSTGYGAAVKTAKVSPGSTCAVFGLGGVGLSVVMGCKAAGASRIIGIDINKDKFQKALDVGATECINPRDFTKPISEVLSDMTGNTVQYTFEVIGRLETMVDALSSCHMNYGTSVVVGAPPSAKMLSYDPMLLFTGRTWKGCVFGGWKSRDDVPKLVTEFLEKKFDLGQLITHTLPFHNISEGFELLYSGQSIRTVLTF
Protein: NAD-specific glutamate dehydrogenase (NAD-GDH) (EC 1.4.1.2) (P33327)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.
Interaction partners:
- Glutamine synthetase
- NADP-specific glutamate dehydrogenase 1
- Glutamate decarboxylase
- Glutamate synthase
- NADP-specific glutamate dehydrogenase 2
- Aspartate aminotransferase, cytoplasmic
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Alanine aminotransferase, mitochondrial
- Aspartate aminotransferase, mitochondrial
- 4-aminobutyrate aminotransferase
Sequence:
MLFDNKNRGALNSLNTPDIASLSISSMSDYHVFDFPGKDLQREEVIDLLDQQGFIPDDLIEQEVDWFYNSLGIDDLFFSRESPQLISNIIHSLYASKLDFFAKSKFNGIQPRLFSIKNKIITNDNHAIFMESNTGVSISDSQQKNFKFASDAVGNDTLEHGKDTIKKNRIEMDDSCPPYELDSEIDDLFLDNKSQKNCRLVSFWAPESELKLTFVYESVYPNDDPAGVDISSQDLLKGDIESISDKTMYKVSSNENKKLYGLLLKLVKEREGPVIKTTRSVENKDEIRLLVAYKRFTTKRYYSALNSLFHYYKLKPSKFYLESFNVKDDDIIIFSVYLNENQQLEDVLLHDVEAALKQVEREASLLYAIPNNSFHEVYQRRQFSPKEAIYAHIGAIFINHFVNRLGSDYQNLLSQITIKRNDTTLLEIVENLKRKLRNETLTQQTIINIMSKHYTIISKLYKNFAQIHYYHNSTKDMEKTLSFQRLEKVEPFKNDQEFEAYLNKFIPNDSPDLLILKTLNIFNKSILKTNFFITRKVAISFRLDPSLVMTKFEYPETPYGIFFVVGNTFKGFHIRFRDIARGGIRIVCSRNQDIYDLNSKNVIDENYQLASTQQRKNKDIPEGGSKGVILLNPGLVEHDQTFVAFSQYVDAMIDILINDPLKENYVNLLPKEEILFFGPDEGTAGFVDWATNHARVRNCPWWKSFLTGKSPSLGGIPHDEYGMTSLGVRAYVNKIYETLNLTNSTVYKFQTGGPDGDLGSNEILLSSPNECYLAILDGSGVLCDPKGLDKDELCRLAHERKMISDFDTSKLSNNGFFVSVDAMDIMLPNGTIVANGTTFRNTFHTQIFKFVDHVDIFVPCGGRPNSITLNNLHYFVDEKTGKCKIPYIVEGANLFITQPAKNALEEHGCILFKDASANKGGVTSSSMEVLASLALNDNDFVHKFIGDVSGERSALYKSYVVEVQSRIQKNAELEFGQLWNLNQLNGTHISEISNQLSFTINKLNDDLVASQELWLNDLKLRNYLLLDKIIPKILIDVAGPQSVLENIPESYLKVLLSSYLSSTFVYQNGIDVNIGKFLEFIGGLKREAEASA
Protein: Ato5p (A0A1D8PKD7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Transcriptional regulator STP2
Sequence:
MSSSASITSDIKALEASSEIENVEPYKTCTITGDGNEFVVIGDHKYYRHELMQAFGGTFNPGLAPYPKHSYGNPAAIGLVATSMNIFILGLFFAHAMGIHVPNVAVGLFVFMGGVVQFLAGIWGFFIGSQVGTFIFIVFTSYGAFWLSFGAIFIPAFGIGEAYAEHPEQLNQGIGLMSVGWAIFTTMLVLCVMKSTLSFFWALFTLDLTIILLAAGFLLDSDKVKIAGGIMGVINTFAGWFEAFAGVANTHNSYLVPKEIPLPDLSLWFKRKKSENQPSE
Protein: Autophagy-related protein 37 (C4R8D7)
Organism: Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Function: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy. Required for both micropexophagy and macropexophagy, but not for the cytoplasm to vacuole transport (Cvt) or autophagy pathways. Required for functional micropexophagic apparatus (MIPA) and relocation of ATG11 to the peroxisome-sequestering arms of the vacuole. Binds palmytoyl-CoA but not oleyl-CoA.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:24535825}; Single-pass membrane protein {ECO:0000269|PubMed:24535825}. Note=Localization to the peroxisome is ATG30-dependent.
Interaction partners:
- Peroxisomal membrane protein PEX14
Sequence:
MSESIDRVFVKAIGTIRTLSSRTGYGGLPRPPIENRVKLYGLYKQATEGDVAGVMERPLGDSPEAEAAKRKWDAWRSEQGTSKTEAKRQYISYLIDTMKQFASDTTEARELLSELEYLWNQISDVSPNDSSDSESNAGPAQLLQNHAQLLSRDISVVDDPITSSGMDPMYNPSFQRHNSSRFINASTAERLNSLSNYYSNLNPTPPLSSRRYQGSVTPRNVDFIKWQNDINNSINKLNHDLQLLANRRLQSSASDPLYSKRGSDLTHDDFVNDISSSSSNRRFRARRNQPLVSKVLLGTISLLLKLIKTVIKHVAIDAVIIAVLVAVIKRSIIIPNLISNEISLQKIHHSELESNSSIKGDSNGGRLTIVLPFINGKDFFQENSLLGKLLKVFHDYVDHVSRIRLIKRN