wanglab/gogpt-training-data huggingface dataset:
Protein: BBSome complex member BBS7 (BBS2-like protein 1) (Bardet-Biedl syndrome 7 protein homolog) (Q8K2G4)
Organism: Mus musculus (Mouse)
Function: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).
Subcellular location: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q8IWZ6}. Cytoplasm {ECO:0000250|UniProtKB:Q8IWZ6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q8IWZ6}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23807208}.
Interaction partners:
- BBSome complex member BBS4
- Protein PTHB1
- Tetratricopeptide repeat protein 8
- BBSome complex member BBS1
- BBSome complex member BBS5
- BBSome complex member BBS2
- BBSome interacting protein 1
- BBSome complex assembly protein BBS10
- Chaperonin-containing T-complex member BBS12
- Leucine zipper transcription factor-like protein 1
Sequence:
MDLTLSRADYLQVGVTSQKTMKLLPTSRQRATQKVVVGDQDGVVICFGVKKGEAVPVFKTLPGQKISRLELGGAVNTPQEKIFIAAGSEIRGFTKRGKQFLSFETNLTESIKAMYISGSDLFLSASYIYNHYCDCKDQNYYLSGDKINDVICLPVEKLSRVTPVLACQDRVLRVLQGSDVMYEIEVPGPPTVLALHNGDGGDSGEGLLFGTSDGRLGLIQITTSKPIHKWEIRNDKKRGGILCVDSFDIMGDGVKDLLVGRDDGMVEVYSFENANEPVLRFDQMLSESVTSIQGGCVGKDGYDEIVLATYSGWVTGLTTEPTHKESGPGEELKLNQEMQNKISSLRSEIEHLQFKVLQERENYQQSSQSSQAKSTVPSFSINDKFTLNKEDASYSLVLEVRTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDTESNDNFLLATYRCQANTTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGECATFYFQNTFLDTQLECVYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQVHEGNTDFLTPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPMLLEILDSYDQNTLISFFDAA
Protein: Sorting nexin-4 (Autophagy-related protein 24) (Cytoplasm to vacuole targeting protein 13) (P47057)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), autophagy, mitophagy, and pexophagy. Involved in proper sorting of the v-SNARE protein SNC1.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12048214}. Preautophagosomal structure membrane {ECO:0000269|PubMed:12048214}; Peripheral membrane protein {ECO:0000269|PubMed:12048214}. Endosome membrane {ECO:0000269|PubMed:17420293}; Peripheral membrane protein {ECO:0000269|PubMed:12048214}. Note=Endosome and other perivacuolar punctate structures (PubMed:17420293). Associates to phosphatidylinositol 3-phosphate, necessary for peripheral membrane localization to the perivacuolar punctate structures (PubMed:12048214). {ECO:0000269|PubMed:12048214, ECO:0000269|PubMed:17420293}.
Interaction partners:
- Autophagy-related protein 20
- Sorting nexin-41
- Autophagy-related protein 11
- Autophagy-related protein 17
- Synaptobrevin homolog 1
- Vacuolar protein sorting-associated protein 35
- Serine/threonine-protein kinase ATG1
- Autophagy-related protein 29
- Autophagy-related protein 31
- Vacuolar protein sorting-associated protein 17
Sequence:
MTDKGKNDLTSKAKDKARGNPEKPPYWFEIIVSDPQKRTGDPGSSSGYVSYQISTKTNNTSFYDNRGDPESIIVVHRRYSDLLLLHDILLNRFPTCIIPPLPDKKVFQYIAGDRFSQRFTQKRCHSLQNFLRRVSLHPDLSQSKVFKTFLVSKDWESHRKVLQDSLQPNKDEVTDAFMNAFKTVHKQNEEFTEIREKSDKLDRTVTKIDKLFHKVVKKNDSMSEDYTKLGSNLQELQELVTGENEELAAKLKIFNEGVTQLSYGLQDLTKYLDYEYIVDLKDLEHYIDSMRQLIKLKDQKQIDYEELSDYLTRSIKEKNNLISGYGGSNFFANKLEELAGINQEASRREKINKLEGKITSLTGELENAKKVADGFEQECLKEIDHFESVKTAEIKKSLGSLADHHIEFYERILEAWEKVDDSL
Protein: Actin-interacting protein 1-1 (Q9ZU34)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds actin. Enhances the F-actin depolymerization activity of actin-depolymerizing factor (ADF) proteins.
Interaction partners:
- F-actin-capping protein subunit beta
- Protein pleiotropic regulatory locus 1
- Ribosome biogenesis protein WDR12 homolog
- Transducin/WD40 repeat-like superfamily protein
- Putative U4/U6 small nuclear ribonucleoprotein
- Cyclase-associated protein 1
- Protein DECREASED SIZE EXCLUSION LIMIT 1
- Protein ANTHESIS POMOTING FACTOR 1
- Transducin/WD40 repeat-like superfamily protein
- Cell division cycle 20.5, cofactor of APC complex
Sequence:
MAKLLETFPCVPSTERGRGILISGDSKSDTILYCNGRSVFIRSLRQLQDVQVYGEHGYAVTVARYSPNGEWIASADVSGTVRVWGTHNGFVLKNEFRVLAGRVDDLQWSFDGLRIVASGDGKGKSLVRSFAWDSGNTMGDFDGHSRRVLSCAFKPTRPFRIATCGEDFLVNFYDGPPFKFHSSHREHSNFVNCIRYSPDGTKFITVSSDKKGMIYDGKTGDKVGELASEDGHKGSIYAVSWSPDSKRVLTVSADKSAKVWEVAEDGTIGSVIKTLSFMESGGAEDMLVGCLWQNDHLITVSLGGTMSLFSADDMDKPPLLLSGHIKNVTSLAVLGENQKTILSCSYDGLIVKWLKGVGYSCKLQMKDTKIKRLAATESSIFISGYDNMVWRIPLTDNGYGAAEHVDIGHQPLDISIAVDSPEATALVSFDSGVVLLNGLNILSKIDLGFAVAASVISPDGKEAIVGGQDGKLHIYSVSGDNNLKEEAVLEKHRGALTVIRYSPDLTMFASGDANREAVVWDRETKQVKLNNMLFHTARINSLAWSPNNKMVATGSIDTCVIVYEVDKPASSRITARNAHLGGVNAVAFIDDCTVASSGEDASVRLWHIEPQ
Protein: Armadillo repeat-containing protein LFR (Protein LEAF AND FLOWER RELATED) (Q9LS90)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in leaf and flower development. Plays roles in leaf development partly by associating with AS2 and repressing KNAT1/BP transcription. Required for the formation of anther cell layers and normal expression of genes that regulates anther development.
Subcellular location: Nucleus {ECO:0000269|PubMed:18846319, ECO:0000269|PubMed:29775508}. Note=Tends to cluster in the nucleus as discrete rounded speckles. {ECO:0000269|PubMed:18846319}.
Interaction partners:
- Chromatin structure-remodeling complex protein BSH
- Chaperone DnaJ-domain superfamily protein
- SWI/SNF complex subunit SWI3A
- SWI/SNF complex subunit SWI3C
- SWI/SNF complex subunit SWI3B
- Actin-related protein 4
- At3g01890
- SWI/SNF complex component SNF12 homolog
- SWI/SNF complex subunit SWI3D
- Mediator of RNA polymerase II transcription subunit-like protein
Sequence:
MQKRELGKSGGNSGGSSGPPAKRGRPFGSTSANSAAAAAAAAAADAMSPSALLGPSLLVHNSFVEQNNRRIVLALQSGLKSEVTWALNTLTLLSFKEKEDIRRDVMPLAKIAGLLDALLLIIDDWRDIALPKDLTRGTRVRTLGTNASVTGFGNEYDALASIQPPGSGIGSSAAEALGKKSTGKHQSSQWWMEEDGLFNLDDEGRSEKQMCAIAASNVIRNFSFMPDNEVVMAQHRHCLETVFQCIHDHMTEDEELVTNSLETIVNLAHLMDLRIFSSLKQSYININEKKAVQAVVGILNSSVKAWNCAAAELLGRLIINPDNEPFISPLIPQIHKRLIDLLSIQAVDAQAAAVGALYNLVEVNMDCRLKLASERWAVDRLLKVIKTPHPVPEVCRKAAMILENLVSEPQNRGLLLAYENAFAELLFQEGKYSDSFARILYELTARSNSRVASARGIWGM
Protein: SREBP regulating gene protein (SREBF pathway regulator in Golgi 1) (Q9H741)
Organism: Homo sapiens (Human)
Function: Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:32111832}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Membrane-bound transcription factor site-1 protease
Sequence:
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQEERAVRDRNLLQVHDHNQPIPWKVQFNLGNSSRPSNQCRNSIQGKHLITDELGYVCERKDLLVNGCCNVNVPSTKQYCCDGCWPNGCCSAYEYCVSCCLQPNKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA
Protein: Metal-dependent hydrolase (Q8NSM6)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
Sequence:
MVMGPTHAMSGAAVGLAVAQILPAEWGGVTTATEAFIYAGLAAGAALLPDLDSPQATVSRSFGPITQVISRFTENICQTFVNVTRGRKDKHCNNGHRTLTHTVWSAAATGAGATALIGAYGKPAVIGLLFFFLGLAIRGLMPEWSKNADWLLVTGASAALAVGVWNYAPESSFGIVLGSAITVGSLTHLAGDMATKAGIPAFAPVIPLKGKRWWNLKLPKFLSIRANGPADKFLLFVFSVAVIIQIGLVSSGNMSTIMMNLLSPAL
Protein: Adhesion factor (Q2TV77)
Organism: Finegoldia magna (Peptostreptococcus magnus)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKLNKKLLTAALAGALIVTAVPANTFAAEKAPKITENLSEEQAAAKIAELSAEIKTLSERRAEIVAQPWASELTQEGIIEKLQAEETAKKKAYEGAKAAYESATKAWEAAKDAQEKARLAKIEADKKAKAAQGDYYKAIKEAEKERDAAKKAAKEAYDTTIANLQRKFESATAAADKALIELNSAKEALDSAKKSGSNEEQLTRLRKEVEEKELAHETAKNLATRASNERADAKSGAEKALAAAENQADENFQAKKQYLDKKYILSGGWNGSAADLTKLERERLAAIDAYNNAVANTKAAHDAYISARDAFDAASKEYAAATQRTYKITEELKSIEKQLKEKFVTINAILKDQNKGINSLADQLNSELIKELEEFSKLSSSEQFAKIAKLQEELAKLKKEYAKTSEGIQQVKKLVTYQFHVKDTEGKGVQGLTLRLANIDDTSKVYTATSDANGLIQFKSMVEGKYSVTVTKVPTGYDVYQDGKKIDSVKALFRAESEVKAENNAEETKKEETKGNKRVDIPSIIDNTTEGNGEKEEKDNKDEKVIDKATIVVEKKKKDNEDNKDNKKPEKKETKKPAKPAKQRLPKAGAAAEAATIAAAAMATMGGAYISLKKRK
Protein: Semaphorin-3A (Semaphorin III) (Sema III) (Semaphorin-D) (Sema D) (O08665)
Organism: Mus musculus (Mouse)
Function: Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Plexin-A2
- Plexin-A1
- Plexin-A4
- Neuropilin-1
- Plexin-A3
- Neuropilin-2
- Plexin-D1
- Plexin-B1
- Atrial natriuretic peptide receptor 1
- Dihydropyrimidinase-related protein 1
Sequence:
MGWFTGIACLFWGVLLTARANYANGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLEAYNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSVPKETWHDLEEILLEEMTVFREPTTISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRRQDIRNGDPLTHCSDLQHHDNHHGPSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRKEEIRMGDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELLHKDDDGDGSKIKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHSQGSSNKWKHMQESKKGRNRRTHEFERAPRSV
Protein: Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) (Q01973)
Organism: Homo sapiens (Human)
Function: Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells.
Subcellular location: Membrane {ECO:0000269|PubMed:27162350}; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z139}.
Interaction partners:
- Protein Wnt-5a
- Tyrosine-protein kinase transmembrane receptor ROR2
- Frizzled-2
- Frizzled-7
- Frizzled-1
- Frizzled-4
- Frizzled-5
- Frizzled-10
- Frizzled-8
- Frizzled-9
Sequence:
MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIALLFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGITVFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL
Protein: UDP-sugar transporter UST74c (Protein fringe connection) (Q95YI5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the import of UDP-sugars from the cytoplasm into the Golgi lumen.
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein.
Interaction partners:
- Adenosine 3'-phospho 5'-phosphosulfate transporter 1
- Endoplasmic reticulum GDP-fucose transporter
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- IP10585p
- UDP-galactose transporter senju
- Solute carrier family 35 member B1 homolog
Sequence:
MSMSRGGNTTLDLQPLLAESDVGNRELEEKMGGSADRSSLLDGSGSKELSHREREDSALFVKKIGSALFYGLSSFMITVVNKTVLTSYHFPSFLFLSLGQLTASIVVLGMGKRLKLVNFPPLQRNTFAKIFPLPLIFLGNMMFGLGGTKTLSLPMFAALRRFSILMTMLLELKILGLRPSNAVQVSVYAMIGGALLAASDDLSFNMRGYIYVMITNALTASNGVYVKKKLDTSEIGKYGLMYYNSLFMFLPALALNYVTGNLDQALNFEQWNDSVFVVQFLLSCVMGFILSYSTILCTQFNSALTTTIVGCLKNICVTYLGMFIGGDYVFSWLNCIGINISVLASLLYTYVTFRRKRAPDKQDHLPSTRGENV
Protein: Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (p134mDIA2) (mDIA2) (Q9Z207)
Organism: Mus musculus (Mouse)
Function: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19117945, ECO:0000269|PubMed:23558171}. Nucleus {ECO:0000269|PubMed:19117945, ECO:0000269|PubMed:23558171}. Note=During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis (By similarity). Shuttles between the cytoplasm and the nucleus (PubMed:19117945). {ECO:0000250|UniProtKB:Q9NSV4, ECO:0000269|PubMed:19117945}.
Interaction partners:
- Protein diaphanous homolog 1
- Cell division control protein 42 homolog
- BAR/IMD domain-containing adapter protein 2
- Transforming protein RhoA
- Anillin
- Rho-related GTP-binding protein RhoB
- Formin-like protein 3
- Profilin-4
- Rho-related GTP-binding protein RhoD
- Vasodilator-stimulated phosphoprotein
Sequence:
MERHRARALGRDSKSSRRKGLQSAPPAGPYEPGEKRPKLHLNIRTLTDDMLDKFASIRIPGSKKERPPLPHLKTVSGISDSSSLSSETMENNPKALPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYINTASKTGSLRSSRQISPQEFLHELKMGYTDERLFTYLESLRVSLTSHPVSWVQSFGHEGLGLLLDILEKLINGQIQEKVVKKTQHKVIQCLRALMNTQYGLERIMSDKRSLSLLAKAMDPRQPAMMADVVKLLSAVCIVGEESILEEVLEALTSAGEERKIDRFFSIVEGLRHNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLDIQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLLIRNDRFIREQYFKLIDECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWEEKASEHCKKFEKECTDHQETQAQLQKREAKINELQAELQAFKSQFGALPPGTKIPLQPSVEGEAGPSALPPAPPALSGGVPPPPPPPPPPPPPLPGMPMPFGGPVPPPPPLGFLGGQSSIPLNLPFGLKPKKEFKPEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFDEKKVIKKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSADQKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLETFPPPEDLHDKFVIKMSSFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEEFFNDLNNFRTSFMLALKENIKKREAAEKEKRARIAKERAEKERLERQQEKKRLLEMKTEGDETGVMDSLLEALQSGAAFRDRRKRTPKLKDIRQSLSPMSQRPVLKVCNHENQKMQLTEGSRPHHSINCNSTRTPVAKELNYNLDTHASTGRIKAVEKEACNAESNKKKEMELLGSVAKSESVPEVEALLARLRAL
Protein: Uncharacterized protein C824.09c (Q9UT34)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTPase-activating protein for the ADP ribosylation factor family.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi apparatus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Kinesin-like protein 8
Sequence:
MINSKSKKKESNALVLKSLLREPYNKVCADCKRNEQPRWASWNLGVFICIRCSGVHRSLGVHVSRVKSVDLDSWTDEQTENMTRWGNERANLYWEAKLAGGHVPSDSKIATFIKTKYEFKKWVLYPEIPSPETLKPEQNTRPVSEVNASLDLNTASRSSSAHSVKSTSSATVTNVTSKKEAISATTSLAQSSPNLASLSKQPSTVHAPSTRQRDLKSSILSLYASPRPQVSSSSITTNATYQNLPSPVSTSTTSSQPYGAFHQPATTGSSFVADKWKMPMFTSNVTSAQPSARASPVQSNSSRPRSSLDSKIINSHDVWK
Protein: Protein EFFECTOR OF TRANSCRIPTION 3 (AtET3) (Q9FJT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17991462}.
Interaction partners:
- Protein EFFECTOR OF TRANSCRIPTION 1
- Uncharacterized protein
Sequence:
MSFVLLSKMAKLKFNHIRHTIISTQKSTTIMPGISQLLNNRLIGKEFSSAVPTMFKREDYKLTIHDIAFSKWRNLIRHNDWKDFNNRKERVRRYRHEDLPPQRCTGLYELGVGVIGQDQGQNFDPDNNVLGVYVGQCVDVKSRLQDYGRRGGHLPSGLYEDIFSEGYSVFYRWAPEAAATEGMLLSTFDYAWNTCSNGERRHLELQKLGDPEFMSKRKSQVLVPSIRDQVVTIKVEKSNYTFLTSTLKVMRPFG
Protein: Uncharacterized oxidoreductase C22A12.17c (EC 1.-.-.-) (O13908)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized oxidoreductase C1739.08c
- Sorbose reductase sou1
- Peroxide stress-activated histidine kinase mak3
- Transcription factor atf21
- Peroxide stress-activated histidine kinase mak1
- Peroxide stress-activated histidine kinase mak2
Sequence:
MVAPAHNYESRNILDLLSLKGKNAVVFGGARGIGHAICSVFAEAGANAFIVYNTTPGEKAAKEIAQANGVKTYTCKCDVTIPKEVEHAFAEIQKVFDTIDIVVPNNGICTGKSAIDMTYEEFANEINVNLLGVFNVAHNAGPIFQKQGHGSLVATASMSGVVVNVPQQQCAYNTSKAGVIQLIKSLAVEWRKFARVNCVSPGYTTSDMTGGKFHKEWEPYTPFERNGLAKEIASAYLYLASDAASYASGTNLIVDGGYTSI
Protein: Cerberus (Cerberus-related protein) (DAN domain family member 4) (O95813)
Organism: Homo sapiens (Human)
Function: Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Proto-oncogene Wnt-3
- Nodal homolog
- Protein Wnt-3a
- Protein Wnt-8a
- Protein Wnt-11
- Protein Wnt-5a
- Protein Wnt-9b
- Protein Wnt-7b
- Protein Wnt-8b
- Protein Wnt-2
Sequence:
MHLLLFQLLVLLPLGKTTRHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAVPHLVATSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA
Protein: Fermitin 2 (LD28629p) (Q9VVD2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Integrin linked kinase, isoform A
- Vinculin
- GH23568p
- LIM domain-containing protein
- Integrin beta-PS
- Paxillin, isoform F
- Integrin beta-nu
Sequence:
MIHVGENSWNLRIFITDLALEKTMRVRGDQHIGGIMLQLVDPENPKDWSDHALWWPARNVWLSRTKLTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCKPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPGSFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVRALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQAKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNEDEIDSALKELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRVAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKGRSLADSSYESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVDYLSPKIIRKLSNKAVQRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSSGDHIKTWRYNTMKAWNVNWNIKCMMIQFEDENVVFSCHSADCKVVHEFIGGYIFMSMRSKDTNQTLNEELFHKLTGGWS
Protein: Transcription elongation factor Spt4 (Q57839)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Stimulates transcription elongation.
Interaction partners:
- DNA-directed RNA polymerase subunit Rpo7
- Transcription elongation factor Spt5
- Small ribosomal subunit protein eS31
- GTP-dependent dephospho-CoA kinase
- Small ribosomal subunit protein eS24
- Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
- DNA-directed RNA polymerase subunit Rpo1C
- DNA-directed RNA polymerase subunit Rpo1N
- Transcription factor S
- Transcription initiation factor IIB
Sequence:
MRACLKCKYLTNDEICPICHSPTSENWIGLLIVINPEKSEIAKKAGIDIKGKYALSVKE
Protein: Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM) (Q8N339)
Organism: Homo sapiens (Human)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Interaction partners:
- Metallothionein-1G
- Metallothionein-1H
- Metallothionein-1X
- Metallothionein-1F
- Metallothionein
Sequence:
MDPNCSCTTGVSCACTGSCTCKECKCTSCKKSCCSCCPVGCAKCAHGCVCKGTLENCSCCA
Protein: Spindle pole body-associated protein VIK1 (Vegetative interaction with KAR3 protein 1) (Q12045)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Targets and/or maintains KAR3 at the spindle pole body during vegetative growth.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:10087265, ECO:0000269|PubMed:11729143}. Nucleus {ECO:0000269|PubMed:10087265}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17382884}.
Interaction partners:
- Kinesin-like protein KAR3
- Kinesin-like protein KIP3
- Kinesin-like protein KIP1
- Kinesin-like protein KIP2
- Spindle pole body-associated protein CIK1
- Protein BIM1
- Chromosome transmission fidelity protein 8
- Spindle pole body component 110
- Kinesin-like protein CIN8
- Inner kinetochore subunit MCM21
Sequence:
MASQQNKHAFLSKNRIFHNPDNVSSSKSRNLMDITNTTNTMNGSRPSSMKSSLALPPVKDSFPSVSRSASLNINMSKIKDLKDRQDKIRFQRHTLRTQLIECEREIKTIKFRDLNKSRFELYKKKSKQAKYLKQVRDLTQNLNSKDGERADLIKKNKSALATLQAELDQNLILKRQESQELYNNKLIFWENELQIMENVEPDHEITEEISQLKKTLQELNINWANLQKQNLERQVNHESQLRKDFIAFKEAKLKSMENLTNKHRELLDQIATLQSESEKLHKEIMDIDRQAEYSEQNISEINENIKQLELANNPLISKSLQNSQDLEHLQNQMENLKEMASKQEKFYNDTYNTVEKELLRSRRLENSIIEQKGTMRCYAYVMEQNLPENLLFDYENGVITQGLSEHVYKFNRVIPHLKVSEDKFFTQEYSVYHDMCLNQKKNFNLISLSTTPHGSLRESLIKFLAEKDTIYQKQYVITLQFVFLSDDEFSQDMLLDYSHNDKDSIKLKFEKHSISLDSKLVIIENGLEDLPLNFSCDEHPNLPHSGMGIIKVQFFPRDSKSDGNNDPVPVDFYFIELNNLKSIEQFDKSIFKKESCETPIALVLKKLISDTKSFFLLNLNDSKNVNKLLTISEEVQTQLCKRKKKLT
Protein: serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (Q9VF85)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Phosphoseryl tRNA kinase, isoform A
- Lysine--tRNA ligase
- Tryptophan--tRNA ligase, cytoplasmic
- Probable arginine--tRNA ligase, cytoplasmic
- Tyrosine--tRNA ligase, mitochondrial
- Tyrosine--tRNA ligase
- leucine--tRNA ligase
- leucine--tRNA ligase
- Bifunctional glutamate/proline--tRNA ligase
- Probable glutamine--tRNA ligase
Sequence:
MKLPTNSQLWRPLLLLRRQRSHDAKAVEAPIHRPVPTSAQLDELERNVVVRHHKNNVPLIRSLIQELDAGDQHKLRQLQAELEQLPNATHPRLRDYGEEPRELAQYVHRQLTPQSRLKEFSELARALNLYRMDHLGNYTGHKSYYLTGQLATLEQAIIQYALQAVTEHGFKLISVPDILPKEVIESCGMRTEGERTQVYKLDTGECLSGTSEMALAGFFANKLLSEDQLPLKVTAVSRCYRAETSGLQEEKGIYRVHQFNKVEMFAICTEEQSEAELEEFKNIEVDLFRRLGLNFRLLDMPPCELGAPAYQKYDIEAWMPGRQMWGEISSCSNCTDYQARRLGIRYRRSADGQILHAHTINGTATAIPRLLIALLESYQKEDGIEIPAVLRPFMDNQELITRNKRIPETKLVKFIKA