wanglab/gogpt-training-data huggingface dataset:
Protein: Poly(A) RNA polymerase cid13 (PAP) (EC 2.7.7.19) (Caffeine-induced death protein 13) (Polynucleotide adenylyltransferase cid13) (Q9UT49)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Polymerase that creates the 3' poly(A) tail of suc22 mRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12062100, ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ribonucleoside-diphosphate reductase small chain
- Nuclear import protein mog1
Sequence:
MDNANCVGGCKFETRSFQYRRRIPYSLGADPLPPVHPLSLKNLVDIDTDLISSQLYELYDSIILNDSGLERRYAFVQKLEQILKKEFPYKNIKTSLFGSTQSLLASNASDIDLCIITDPPQCAPTTCEVSAAFARNGLKKVVCISTAKVPIVKVWDSELQLSCDCNINKTISTLNTRLMRSYVLCDPRVRPLIVMIKYWAKRRCLNDAAEGGTLTSYTISCMVINFLQKRDPPILPSLQMLPHLQDSSTMTDGLDVSFFDDPDLVHGFGDKNEESLGILFVEFFRFFGYLFDYEHFVLSIRHGTFLSKRAKGWQFQLNNFLCVEEPFHTSRNLANTADEITMKGIQLEFRRVFRLLAYNCNVDDACSQFTFPSLTDTSFMDDYVNELQLEIVPGFSHGRDSSDTSCTESPPEPSHFAWAFDPYNATASPYYNQNINSSIDYSSIYSNDVPAIPPNVPYTFVDPYTYACYINNNSYLPPSYMDFYTWYNSPYPKSSHHFDERHGGDRHEKNLSNSRRYSRNKFHKKKQSSGPFQYYPDAFSFTPTDNNSPPSNSSSSEVVSPVSLHSEPVLSTVQAFKS
Protein: L-type lectin-domain containing receptor kinase IX.2 (LecRK-IX.2) (EC 2.7.11.1) (Q9LSL5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes hydrogen peroxide H(2)O(2) production and cell death.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9LSR8}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- 2-oxoglutarate
- Uncharacterized membrane protein At3g27390
- Small ribosomal subunit protein mS81
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Dof zinc finger protein DOF5.7
- At1g64385
- Putative pectate lyase 11
Sequence:
MLYFIFCQNLSSSSSMSNSILFLSLFLFLPFVVDSLYFNFTSFRQGDPGDIFYHGDATPDEDGTVNFNNAEQTSQVGWITYSKKVPIWSHKTGKASDFSTSFSFKIDARNLSADGHGICFFLAPMGAQLPAYSVGGFLNLFTRKNNYSSSFPLVHVEFDTFNNPGWDPNDVGSHVGINNNSLVSSNYTSWNASSHSQDICHAKISYDSVTKNLSVTWAYELTATSDPKESSSLSYIIDLAKVLPSDVMFGFIAAAGTNTEEHRLLSWELSSSLDSDKADSRIGLVIGISASGFVFLTFMVITTVVVWSRKQRKKKERDIENMISINKDLEREAGPRKFSYKDLVSATNRFSSHRKLGEGGFGAVYEGNLKEINTMVAVKKLSGDSRQGKNEFLNEVKIISKLRHRNLVQLIGWCNEKNEFLLIYELVPNGSLNSHLFGKRPNLLSWDIRYKIGLGLASALLYLHEEWDQCVLHRDIKASNIMLDSEFNVKLGDFGLARLMNHELGSHTTGLAGTFGYMAPEYVMKGSASKESDIYSFGIVLLEIVTGRKSLERTQEDNSDTESDDEKSLVEKVWELYGKQELITSCVDDKLGEDFDKKEAECLLVLGLWCAHPDKNSRPSIKQGIQVMNFESPLPDLPLKRPVAMYYISTTTSSSSPSVNSNGVSVTFSGIEYGR
Protein: Zinc finger protein 232 (Zinc finger and SCAN domain-containing protein 11) (Q9UNY5)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus.
Interaction partners:
- Zinc finger and SCAN domain-containing protein 32
- Zinc finger protein 446
- Zinc finger protein 397
- Zinc finger protein 24
- Zinc finger and SCAN domain-containing protein 20
- Zinc finger protein with KRAB and SCAN domains 3
- Zinc finger protein with KRAB and SCAN domains 4
- Zinc finger and SCAN domain-containing protein 30
- Zinc finger protein with KRAB and SCAN domains 5
- SCAN domain-containing protein 3
Sequence:
MEPPGPVRGPLQDSSWYEPSAELVQTRMAVSLTAAETLALQGTQGQEKMMMMGPKEEEQSCEYETRLPGNHSTSQEIFRQRFRHLRYQETPGPREALSQLRVLCCEWLRPEKHTKEQILEFLVLEQFLTILPEELQSWVRGHHPKSGEEAVTVLEDLEKGLEPEPQVPGPAHGPAQEEPWEKKESLGAAQEALSIQLQPKETQPFPKSEQVYLHFLSVVTEDGPEPKDKGSLPQPPITEVESQVFSEKLATDTSTFEATSEGTLELQQRNPKAERLRWSPAQEESFRQMVVIHKEIPTGKKDHECSECGKTFIYNSHLVVHQRVHSGEKPYKCSDCGKTFKQSSNLGQHQRIHTGEKPFECNECGKAFRWGAHLVQHQRIHSGEKPYECNECGKAFSQSSYLSQHRRIHSGEKPFICKECGKAYGWCSELIRHRRVHARKEPSH
Protein: Transcription factor MYB3 (Myb-related protein 3) (AtMYB3) (Q9S9K9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:18541146}.
Interaction partners:
- Protein TRANSPARENT TESTA GLABRA 1
- Transcription factor EGL1
- MYB-like transcription factor TCL1
- Transcription factor TT8
- Dihydroflavonol 4-reductase
- Trans-cinnamate 4-monooxygenase
Sequence:
MGRSPCCEKAHMNKGAWTKEEDQLLVDYIRKHGEGCWRSLPRAAGLQRCGKSCRLRWMNYLRPDLKRGNFTEEEDELIIKLHSLLGNKWSLIAGRLPGRTDNEIKNYWNTHIKRKLLSRGIDPNSHRLINESVVSPSSLQNDVVETIHLDFSGPVKPEPVREEIGMVNNCESSGTTSEKDYGNEEDWVLNLELSVGPSYRYESTRKVSVVDSAESTRRWGSELFGAHESDAVCLCCRIGLFRNESCRNCRVSDVRTH
Protein: Uncharacterized oxidoreductase C30D10.05c (EC 1.-.-.-) (O14351)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MAETAEKVILLTGSSKGIGLATAEALQKKAKVIAVSRSLTPELETLLIQNPDSFVHVKGDVTEVGKASIETAIKKFGKLDSVILNAGVLEPIAKIADADINEWRKLFDINFFSVVETVKYAIPHLRKTKGTIVIVSSGAAVRVFPAWAAYCCSKAAINMLVMNLGSEEPDIMSVAVRPGVVDTPMQVSIRNDSNKEAMGGDTHNFFKELKTSGQLVAPQDIAKALSFLALNNNPKLTGQFVEWKSFV
Protein: Disabled-1 early isoform (Q6XBN7)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSTETELQVAVKTSTKKDSKKKGQDRSEATLIKRFKGDGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGIVAAARSKGEHKQKIFLTVSFGGIKIFDEKTGLLQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREEMEKKAQKDKQCEQAVYQVPTSQKKEGVYDVPKSQPVSLENGNLLLDIDENLGSVTQAVTQLELFGDMSTPPDVTSPPTPATPGDAFIPSSSQSLPASTDMFGSVPFSTAAVPSGYVAMGAVLPSFWGQQPLVQQQLAMGAQPPVAQVMQGGQPIAWGQPGIFPPAQQPWPSVAGQFQPTAFMPTQTVLPLQAAMFQGTIAPIATVPPTSDSNRSSPQTDRPRQKMGKEMFKDFQMAQPPPVPSRKPDQPSLSCTSEAFSSYFNKVGMAQEADDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHTSDPAADDLFEEGFESPSKSEEQEAPDESQASSNSDPFGEPTGDTISPQVGS
Protein: Calcium-dependent protein kinase 13 (EC 2.7.11.1) (Q8W4I7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19029837}; Lipid-anchor {ECO:0000269|PubMed:19029837}.
Interaction partners:
- Early nodulin-like protein 5
- Calcium-binding protein CP1
- Heat stress transcription factor B-2a
- 17.6 kDa class II heat shock protein
- Glucan endo-1,3-beta-glucosidase 9
Sequence:
MGNCCRSPAAVAREDVKSNYSGHDHARKDAAGGKKSAPIRVLSDVPKENIEDRYLLDRELGRGEFGVTYLCIERSSRDLLACKSISKRKLRTAVDIEDVKREVAIMKHLPKSSSIVTLKEACEDDNAVHLVMELCEGGELFDRIVARGHYTERAAAGVTKTIVEVVQLCHKHGVIHRDLKPENFLFANKKENSPLKAIDFGLSIFFKPGEKFSEIVGSPYYMAPEVLKRNYGPEIDIWSAGVILYILLCGVPPFWAESEQGVAQAILRGVIDFKREPWPNISETAKNLVRQMLEPDPKRRLTAKQVLEHPWIQNAKKAPNVPLGDVVKSRLKQFSVMNRFKRKALRVIAEFLSTEEVEDIKVMFNKMDTDNDGIVSIEELKAGLRDFSTQLAESEVQMLIEAVDTKGKGTLDYGEFVAVSLHLQKVANDEHLRKAFSYFDKDGNGYILPQELCDALKEDGGDDCVDVANDIFQEVDTDKDGRISYEEFAAMMKTGTDWRKASRHYSRGRFNSLSIKLMKDGSLNLGNE
Protein: ceramide glucosyltransferase (EC 2.4.1.80) (Q501W7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MALLDLALQGFAIFGFLLFLVLWLMHLVSIIYVRLHLNKKTPDKMPYSKLAGVSLLKPLKGVDPNLINNLETFFELDYPKYEILLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPAYEGARYELVWICDSGIRVKPDTLTDMANQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGIKCVTGMSCLMRKDILDQAGGLIAFAQYIAEDYFMAKAIADRGWKFSMATQVAMQNSGSYSIAQFQSRMIRWAKLRINMLPGTIIEPISECFVASLIIGWAAHHVFRWDIMVFFLCHCLAWFISDYIQLRGVQGGPPSFSKLDYAVAWFIRESMTIQIFLSALWDPTISWRAGRYRLRCGGTAEEILDV
Protein: Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (P35249)
Organism: Homo sapiens (Human)
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Replication factor C subunit 1
- Replication factor C subunit 5
- Replication factor C subunit 2
- Cell cycle checkpoint protein RAD17
- Replication factor C subunit 3
- Chromosome transmission fidelity protein 18 homolog
- ATPase family AAA domain-containing protein 5
- Proliferating cell nuclear antigen
- Sister chromatid cohesion protein DCC1
- Chromosome transmission fidelity protein 8 homolog
Sequence:
MQAFLKGTSISTKPPLTKDRGVAASAGSSGENKKAKPVPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQQRLLDIAKKENVKISDEGIAYLVKVSEGDLRKAITFLQSATRLTGGKEITEKVITDIAGVIPAEKIDGVFAACQSGSFDKLEAVVKDLIDEGHAATQLVNQLHDVVVENNLSDKQKSIITEKLAEVDKCLADGADEHLQLISLCATVMQQLSQNC
Protein: Bifunctional dihydrofolate reductase-thymidylate synthase 1 (DHFR-TS 1) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] (Q05762)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
Interaction partners:
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Bifunctional dihydrofolate reductase-thymidylate synthase 2
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Thymidine kinase b
- Thymidine kinase a
- Folylpolyglutamate synthase
- Thymidylate kinase
- dCMP deaminase
- Dihydrofolate synthetase
- Folylpolyglutamate synthase
Sequence:
MATTTLNDSVTTTLASEPQRTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDITLTTSDSSKKNAVVMGRKTWESIPIKYRPLSGRLNVVLTRSGGFDIANTENVVTCSSVDSALDLLAAPPYCLSIERVFVIGGGDILREALNRPSCDAIHLTEIDTSVDCDTFIPAIDTSVYQPWSSSFPVTENGLRFCFTTFVRVKSSADESSDESNGSQSLQFDGKKFLFLPKMVFDQHEEFLYLNMVEDIISNGNVKNDRTGTGTLSKFGCQMKFNLRRSFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLVDVIDKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVAEGELSCQMYQRSADMGLGVPFNIASYSLLTCMLAHVCDLVPGDFIHVLGDAHVYKTHVRPLQEQLLNLPKPFPVMKINPEKKQIDSFVASDFDLTGYDPHKKIEMKMAV
Protein: CDGSH iron-sulfur domain-containing protein 1 (Cysteine transaminase CISD1) (EC 2.6.1.3) (MitoNEET) (B0K020)
Organism: Rattus norvegicus (Rat)
Function: L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate (By similarity). The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine). The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate. The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (By similarity). Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in iron-sulfur cluster shuttling and/or in redox reactions. Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9NZ45}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q9NZ45}.
Interaction partners:
- DNA damage-binding protein 1
- DET1- and DDB1-associated protein 1
Sequence:
MGLSSDSPVRVEWIAAVTFAAGTAALGYLAYKKFYAKESRTKAMVNLQIQKDNPKVVHAFDMEDLGDKAVYCRCWRSKKFPFCDGAHIKHNEETGDNVGPLIIKKKET
Protein: Echinoderm microtubule-associated protein-like 2 (EMAP-2) (Q6P6T4)
Organism: Rattus norvegicus (Rat)
Function: Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O95834}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:O95834}. Note=Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle. {ECO:0000250|UniProtKB:O95834}.
Interaction partners:
Sequence:
MSSFGTGKTKEVIFSMEEGSVKMFLRGRPVPMLIPDELAPTYSLDTRSELPSSRLKLDWVYGYRGRDCRANLYLLPTGEVVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAVHPDMVTIATGQVAGTTKEGKPLPPHVRVWDSVSLSTLHVLGLGVFDRAVCCVAFSKSNGGNLLCAVDESNDHVLSVWDWAKESKVVDSKCSNEAVLVATFHPTDPNLLITCGKSHIYFWSLEGGNLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQEVLGAHDGGVFALCALRDGTLVSGGGRDRRVVLWGSDYSKVQEVEVPEDFGPVRTVAEGRGDTLYVGTTRNSILLGSVHTGFSLLVQGHVEELWGLATHPSRAQFVSCGQDKLVHLWSSETHQPVWSRSIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTDTRDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSTCFVTNSGDYEILYWDAATCKQITSADTVRNVQWATATCVLGFGVFGIWPEGADGTDINAVARSHDGNLLVSADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMVLTTGGKDTSVLQWRVA
Protein: Chloride channel protein ClC-Kb (Chloride channel Kb) (ClC-K2) (Q9WUB6)
Organism: Mus musculus (Mouse)
Function: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. May be the basolateral chloride channel mediating net chloride absorption in CTAL cells.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:27335120, ECO:0000305|PubMed:11734858}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Barttin
- Solute carrier family 12 member 1-chloride cotransporter 1)
- ATP-sensitive inward rectifier potassium channel 1
- Solute carrier family 12 member 3
- Chloride channel protein ClC-Ka
Sequence:
MEELVGLREGASKKPVPLQELWGPCPRIRRNIQGGLEWLKERLFRVGEDWYFLVALGVLMALISYAMNFTIGRVVRAHKWLYREIGDGHLLRYLSWTVYPVALLSFSSGFSQSITPSSGGSGIPEVKTILTGVVLEDYLDIKNFGAKVVGLSCTLATGSTIFLGKLGPFVHLSVMIAAYLGRVRTKTVGEPESKTKEMELLAAGAAVGVATVFAAPISGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFHLLAVFNNEQETITSIYKTSFPVDIPFDLPEIFFFVALGAICGILSCGYNYSQRTFLFFLKANGFTSKLLATSKPLYSALAAVVLASITYPPGVGHFMASRLSMSEHLETLFDNNSWALMTKNSSPPWAAEPDPQKLWLEWCHPQLTVFGTLVFFLVMKFWMLILATTIPIPAGYFLPIFIYGAVIGRLFGEVLSVAFPEGIVAGGRVNPIMPGAYALAGAAAFSGAVTHTLSTALLAFEVTGQLVHALPVLMAVLAANAISQSFQPSFYDGTIIVKKLPYLPWIRGRQIGSHSVTVGHFMNCALTTLAKDMPLEQVIQVVISTDVTQYPLVETTESQTLVGVVKRTHLVQALQTEPASWAPGQQPCLQDILANGCPTQPVTLQLSLETSLHETHNLFELLNLQTLFVTSRGRAVGSVSWVELKKAISTLTNPPAPK
Protein: Secreted chorismate mutase (CM) (EC 5.4.99.5) (*YpCM) (Q7CHH5)
Organism: Yersinia pestis
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity.
Subcellular location: Periplasm {ECO:0000269|PubMed:18727669}.
Interaction partners:
- Chorismate synthase
- Similar to Escherichia coli T-protein [includes: chorismate mutase and prephenate dehydrogenase] TyrA SW:TYRA_ECOLI
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL22
- Small ribosomal subunit protein uS3
- Similar to Escherichia coli hypothetical protein YbeL SW:YBEL_ECOLI
- Large ribosomal subunit protein uL11
- Tryptophan biosynthesis protein TrpCF
- Small ribosomal subunit protein uS17
Sequence:
MQPTHTLTRLTVIGKLIIASSFFLSLAVQAQQCGQTAPLINERLSYMKDVAGYKAENHLPIEDRIQEEKVINSAMAQAESLGLNGESIKPLMVAQINAAKAIQYRYRADWLSQPEPGWQPKPLDDVRANIGELSTKILEQIAEELKTCKPAEMGDKAHFINTIRQHNLTSADVEAIFSTFNQVKLK
Protein: Anti-adapter protein IraP (P0AAN9)
Organism: Escherichia coli (strain K12)
Function: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Regulator of RpoS
- Anti-adapter protein IraM
- Anti-adapter protein IraD
- RNA polymerase sigma factor RpoS
Sequence:
MKNLIAELLFKLAQKEEESKELCAQVEALEIIVTAMLRNMAQNDQQRLIDQVEGALYEVKPDASIPDDDTELLRDYVKKLLKHPRQ
Protein: Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) (Q9Y4F5)
Organism: Homo sapiens (Human)
Function: Plays a role in microtubule organization.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q498L0}.
Interaction partners:
Sequence:
MSATSWFLVSSSGARHRLPRELIFVGREECELMLQSRSVDKQHAVINYDQDRDEHWVKDLGSLNGTFVNDMRIPDQKYVTLKLNDVIRFGYDSNMYVLERVQHRVPEEALKHEKYTSQLQVSVKGLAPKRSEALPEHTPYCEASNPRPEKGDRRPGTEAASYRTPLYGQPSWWGEDDGSTLPDAQRQGEPYPERPKGPVQQDGELHGFRAPAEPQGCSFRREPSYFEIPTKETPQPSQPPEVPAHEMPTKDAEAGGGGAAPVVQSHASFTIEFDDCSPGKMKIKDHITKFSLRQRRPPGKEATPGEMVSAETKVADWLVQNDPSLLHRVGPGDDRHSTKSDLPVHTRTLKGHKHEDGTQSDSEDPLAKAASAAGVPLEASGEQVRLQRQIKRDPQELLHNQQAFVIEFFDEDTPRKKRSQSFTHSPSGDPKADKRRGPTPADRDRPSVPAPVQAGGRSSGPQRAGSLKREKTEERLGSPSPASRTPARPFGSVGRRSRLAQDFMAQCLRESSPAARPSPEKVPPVLPAPLTPHGTSPVGPPTPPPAPTDPQLTKARKQEEDDSLSDAGTYTIETEAQDTEVEEARKMIDQVFGVLESPELSRASSATFRPVIRGDRDESDDGGVAQRMALLQEFASRPLGAAPQAEHQGLPVPGSPGGQKWVSRWASLADSYSDPGLTEDGLGRRGGEPEGSLPVRMRRRLPQLPSERADSPAGPESSRRSGPGPPELDSEQPSRLFGQEELDPDSLSDASGSDGGRGPEPGVEPQDSRRRSPQEGPTWSRGRRSPRAPGEPTPASFFIGDQNGDAVLSRKPLAAPGDGEGLGQTAQPSPPARDGVYVSANGRMVIQLRPGRSPEPDGPAPAFLRQESFTKEPASGPPAPGKPPHISSHPLLQDLAATRAARMDFHSQDTHLILKETETALAALEARLLSNSVDAECEGGSTPRPPEDALSGDSDVDTASTVSLRSGKSGPSPTTPQPLRAQKEMSPSPPAAQDPGGTALVSAREQSSERQHHPLGPTDMGRGEPVRRSAIRRGHRPRGSLDWPSEERGPVLAHLPSSDVMASNHETPEATGAGRLGSRRKPAAPPPSPAAREEQSRSSASSQKGPQALTRSNSLSTPRPTRASRLRRARLGDASDTEAADGERGSLGNPEPVGRPAAEQAKKLSRLDILAMPRKRAGSFTGTSDPEAAPARTSFSGRSVELCCASRKPTMAEARAVSRKAANTATTTGPRQPFSRARSGSARYTSNTRRRQQGSDYTSTSEEEYGSRHGSPKHTRSHTSTATQTPRAGSSSRARSRAPGPRDTDDDEEEPDPYGFIVQTAEIAEIARLSQTLVKDVAILAQEIHDVAGDGDTLGSSEPAHSASLSNMPSTPASTISAREELVQRIPEASLNFQKVPPGSLNSRDFDQNMNDSCEDALANKTRPRNREEVIFDNLMLNPVSQLSQAIRENTEHLAEKMKILFQNTGRAWEDLEARINAENEVPILKTSNKEISSILKELRRVQKQLEVINAIVDPSGSLDLLTGNRSLASSAQPGLGKGRVAAQSPPSPASAEALLPALPLRNFPQRASCGPPSLPDPTFLPDAERFLI
Protein: 40S ribosomal protein S26 (Q6FN77)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome G complete sequence
- L33
- 40S ribosomal protein S7
- Small ribosomal subunit protein uS14
- Candida glabrata strain CBS138 chromosome M complete sequence
- Large ribosomal subunit protein uL30
- L17A
- RP28
- Small ribosomal subunit protein eS25
- Candida glabrata strain CBS138 chromosome J complete sequence
Sequence:
MPKKRASNGRNKKGRGHVKPVRCVNCSKSVPKDKAIKRMAIRNIVEAAAVRDLSEASVYSEYVLPKTYNKLHYCVSCAIHARIVRVRSREARRIRTPPQRPRFNRENKVSPADAAKKAL
Protein: At2g41950/T6D20.26 (DNA-directed RNA polymerase subunit beta) (O23684)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable CCR4-associated factor 1 homolog 2
- Small ribosomal subunit protein bS20c
- Stromal processing peptidase, chloroplastic
- Protein PIGMENT DEFECTIVE 338, chloroplastic
- DUF241 domain protein, putative
- At3g51410
- Carrier protein
- DUF241 domain protein, putative
- Uncharacterized protein
- Expressed protein)
Sequence:
MFSLSFPSSSSALLPSLVAFDSSRRLSLQPKKLNRLQSHLFSPQHLSFSQSNVSRYRAFCVSSSSPPEGTVSVVDFHEKDWSFLESMEIDSTEHTQKIERIIKAGELSESSRVLVSISSETFVDRLVESSPSQLLLIVHDSLFTLACIKEKYDKVKCWQGEMIYVPEKWSPLDAVFLYFLPALPFDLDELFKTLSQRCSSGARVVISHPQGRLGLEQQRKEFSDVVVSDLPDESTLSNVAEKHSFELTQFVDEQGLYLAVLKSSKQ
Protein: Replication factor C subunit 3 (Q18547)
Organism: Caenorhabditis elegans
Interaction partners:
- Replication factor C subunit 4
- Replication factor C subunit 2
- Replication factor C subunit 1
- Probable replication factor C subunit 5
- AAA+ ATPase domain-containing protein
- Sister chromatid cohesion protein DCC1
- Proliferating cell nuclear antigen
- Homolog of S. Pombe Rad
- Ctf8
- DNA replication licensing factor mcm-6
Sequence:
MALWVDKYRPKDLLGKDGVDYHIEQANHLKFLSADCMPHLLFCGPSGAGKKTRIKCLLRELYGVGVEKTQLIMKSFTSPSNKKLEIQTVSSNYHIEMTPSDVGIYDRVVVQDLVKEMAQTSQIESTSQRSFKVVVLCEADSLTRDAQHGLRRTMEKYANNCKIVLSCESLSRIIEPLQSRCIIINVPAPTDEDVTKVLRKVIERESFLLPENVLQKIVEKSEGNLRRAILMTEALRMENESGVAESVVIPVPEWEIYIQETARLILQKQSSDMLLKVRERLYELLSRCIPPTVIFKKLLEHLLPKCPPQIAREVVSEAAKFEHRLVLGQKAIFHLEGFVAAFMDIYLTNASKPK
Protein: U11/U12 small nuclear ribonucleoprotein 31 kDa protein (U11/U12 snRNP 31 kDa protein) (U11/U12-31K) (Q9CAE4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: RNA chaperone required for proper U12 intron splicing and for normal growth and development of plants. Mainly responsible for meristem activity. Plays a role in regulating cell division.
Subcellular location: Nucleus {ECO:0000269|PubMed:21148817}.
Interaction partners:
- U11/U12 small nuclear ribonucleoprotein 65 kDa protein
- GPN-loop GTPase QQT1
- At4g39040
- Protein DEHYDRATION-INDUCED 19 homolog 2
- U11/U12 small nuclear ribonucleoprotein 25 kDa protein
- U11/U12 small nuclear ribonucleoprotein 48 kDa protein
- U11/U12 small nuclear ribonucleoprotein 59 kDa protein
- Cystatin/monellin superfamily protein
- 65-kDa microtubule-associated protein 7
- GPN-loop GTPase QQT2
Sequence:
MKKRKIHHSDDEEDDTFYYRYSSVAAPPPSNPKHQPSSSAKSSAPGGGSGGLAPSKSTLYVSNLDFSLTNSDIHTLFSTFGKVARVTVLKDRHTRQSRGVAFVLYVSREDAAKAARSMDAKILNGRKLTVSIAADNGRASEFIKKRVYKDKSRCYECGDEGHLSYECPKNQLGPRERPPPPKKRGRRKEEEGEAEEISWSAAAPSLAVAEEEFEEENWASVVDNEAGERLRKREAEEEEERRMKRKEKKVSYFSDESDDED
Protein: Inner membrane complex sub-compartment protein 1 (Q8IJT5)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Repetitive organellar protein
Sequence:
MGNIVSCCSLDENKKYLNDDEILETFSNSEINEFKKRLKNNIQIVVLLQDGTKLPCNLQANFQEKTLCISCHQKVRMINFSDIRSLLYGEEQLKRVETQANLINDNCCLALHLDDSGNCIPIKFGSVKEKNLFIFIMKDYKKNS
Protein: Holes in muscle (RE70039p) (Q9VWX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Fibrinogen C-terminal domain-containing protein
Sequence:
MGVIYKILKQQRSMDLSLSSATRCKVQAAIKQRQQQRRLEDHMVEERDRDRERDQQPDQDQNQVQNHIDKDKEELAEQQLQQLCRFLAENAARKKRQRFKLQYQCNLAIDQDNDQEQMPEKEHFAAPPHEMDLEFIEQLQQSSPAKSHGATGQAPRDSILLKIRHQIFERKRQRQRQLAELVQQRMVVWRPW
Protein: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp) (P0C313)
Organism: Oryza sativa subsp. indica (Rice)
Function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Subcellular location: Plastid, chloroplast stroma {ECO:0000255|HAMAP-Rule:MF_00444}.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- ATP-dependent Clp protease proteolytic subunit
- ATP-dependent Clp protease proteolytic subunit
- ATP-dependent Clp protease proteolytic subunit
- ATP-dependent Clp protease proteolytic subunit
- Clp R domain-containing protein
- Adaptor protein ClpS core domain-containing protein
Sequence:
MPIGVPKVPYRIPGDEEATWVDLYNVMYRERTLFLGQEIRCEVTNHITGLMVYLSIEDGISDIFLFINSPGGWLISGMAIFDTMQTVTPDIYTICLGIAASMASFILLGGEPTKRIAFPHARIMLHQPASAYYRARTPEFLLEVEELHKVREMITRVYALRTGKPFWVVSEDMERDVFMSADEAKAYGLVDIVGDEMLDEHCDTDPVWFPEMFKDW