wanglab/gogpt-training-data huggingface dataset:
Protein: F-box/kelch-repeat protein SKIP4 (SKP1-interacting partner 4) (Q9M2C9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MACIVEDPQRAGQSNETQIALISGVPDDISKSCLARVPREYHMAMKCVSRRWRDFVCSDEMCDYRNEFNLAESWIYALCRDISGGVFLHMLNPFSSRRSWKRINDYPYIPMREGMGFAVLGKRLFVLGGCGWLEDATDEIYCYDAAMNTWFDVVPPLSTKRCYFACETLDGKIIAIGGLGLNPNAKRTWDIYDPLTRTCKSCSDVNIVPEMEDSFVMDGRIYIRGGVGGSSTAVYSASSGIWERMDDDMASGWRGPAVVVAGDLYVLDQTFGAKLTMWCKDTRMWIHIGKLSQLVMKQPCRLVSIGNSIFVIGKDCSTVVIDVENVRKNKMNGVMVCSSIPKTWDDDIDVISCKSVAI
Protein: High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) (P40618)
Organism: Gallus gallus (Chicken)
Function: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Binds to the delta-1 crystallin/ASL1 enhancer. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity).
Subcellular location: Nucleus {ECO:0000305|PubMed:7904558}. Chromosome {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O54879}.
Interaction partners:
- Non-histone chromosomal protein HMG-14B
Sequence:
MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSSKEKAKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLSDGEKQPYNNKAAKLKEKYEKDVADYKSKGKFDGAKGAATKAARKKVEEEDEEEEEDEEEEDEDDDDE
Protein: Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) (P54259)
Organism: Homo sapiens (Human)
Function: Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
Subcellular location: Nucleus. Cytoplasm, perinuclear region. Cell junction {ECO:0000250|UniProtKB:P54258}. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells (By similarity). Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Gln (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles. {ECO:0000250}.
Interaction partners:
- Nuclear receptor subfamily 2 group E member 1
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
- Ataxin-1
- Ataxin-2
- NEDD4-like E3 ubiquitin-protein ligase WWP1
- Huntingtin
- BAR/IMD domain-containing adapter protein 2
- WD repeat-containing protein 5
- NEDD4-like E3 ubiquitin-protein ligase WWP2
- Ataxin-3
Sequence:
MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL
Protein: EMP1-trafficking protein (Q8I490)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MMNKKSMQTKNFLSERNYGSIDQNVRTKNKRRLMKFQSKSKAKSFLFLLELMVFSLFIWILKSAKHNVSSKSIYNKNKFHNTFNRRDTRVLAEQEDQYIRNPNNSNYPDRDLDICNWDEPHNPEKNPCAIPQDDLSNEGIEIIDYVDKKEEEKLKNDLKIHFGKQHYALIKDIYKPIQSYANNFSKVVDHYVGSLKRINNAFNLDILRTVICTAFLIQPIVLLMKLHPELLVHIPINIIISMVVFKLMHKSLRNEQESNK
Protein: Tolloid-like protein 1 (mTll) (EC 3.4.24.-) (Q62381)
Organism: Mus musculus (Mouse)
Function: Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development, especially heart development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Chordin
Sequence:
MGLQALSPRMLLWLVVSGIVFSRVLWVCAGLDYDYTFDGNEEDKTEPIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQSPFGKLGHITGGFGDHGMPKKRGALYQLIERIRRIGSGLEQNNTMKGKAPPKLSEQSEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFTERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESSGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKVAGVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKIMVSEGYHVGLTFQAFEIERHDSCAYDHLEVRDGASENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVIAPSQYRISVKFEFFELEGNEVCKYDYVEIWSGPSSESKLHGKFCGADIPEVMTSHFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYTCQCRNGFVLHENKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWVISAIPGHRITLAFNEFEVEQHQECAYDHLEIFDGETEKSPILGRLCGSKIPDPLMATGNEMFIRFISDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQLDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVEVFDGLSSKAVGLGRFCGSGPPEEIYSIGDVALIHFHTDDTINKKGFYIRYKSIRYPETMHAKN
Protein: GH10882p (Q9VIY3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform A
- LP11159p
- Cilia- and flagella-associated protein 43
- FI23230p1
- AT12351p
Sequence:
MPRVKPTKKLDVLGNLDLRPEDAVGDYISSKQQNKFFVIPPNSDSAGDSIELIYVNNLREHEAMLKLQEEMLTSAKRQTKLNSARVRNMYKIQERLRRRFIEVNSFIKDCADKKRVAEKTAQAETLNHKELGEGIESFKDSIGELKAFREALKATVQEFQPYEKVLDEVVKVSDIFVSPKDCTDRCDALMLAQVEINKLEHQKLQDIENMRQRMVQITNDAALTVLGLKNDLAKLERSYNESRVQCLRWEKILAKTKDAINNNYMDKERTIDAITNLHRILLRRRDVHSFPARGDLDKVLDAIMGEVEILTGVVKEIESSDPSIKHEEARDKSLC
Protein: Wnt ligand secretion mediator (E9PM62)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLE
Protein: Endo-type membrane-bound lytic murein transglycosylase A (EC 4.2.2.n2) (Peptidoglycan lytic endotransglycosylase) (P0C960)
Organism: Escherichia coli (strain K12)
Function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. Prefers cross-linked murein in vivo.
Subcellular location: Cell outer membrane {ECO:0000305|PubMed:9642199}; Lipid-anchor {ECO:0000305|PubMed:9642199}.
Interaction partners:
- Membrane-bound lytic murein transglycosylase A
- Membrane-bound lytic murein transglycosylase D
- Soluble lytic murein transglycosylase
- Membrane-bound lytic murein transglycosylase B
- Membrane-bound lytic murein transglycosylase F
- Endolytic murein transglycosylase
- Anhydromuropeptide permease
- Murein tetrapeptide carboxypeptidase
Sequence:
MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSDRKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM
Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (Q581T0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
Interaction partners:
- Phospholipid-transporting ATPase
Sequence:
MPEVENDSCCSMSTMEEVTPCPVPPIKKRSQRMVIKRWLNMETACEGEPRTIPLGCAPHVWTAAGYPRNAVNNRRYSIITFLPLSLFHQFRPFFNSFYLFLTLTQFVDALKVGFLFTYISPLALVVILSLIKDAVDDIQRYQRDKTINEEKVEKLLLNGEVSVITAAEIQVGDILILHHGQRIPADCVLLRTSEACGTCFIRTDQMDGETDWKLRYALKGTQTLNNVSLSQLRANIRCEPLHKDIYKFVGAFDIPGKESEAISLQNTLWAHCVVASGTLAVAVLHTGVDTRSAMNRSKHSTKVGLIEHELNYLGVLCLSVLVLISFLLVVQQHFEGSWLTMFFRFLILLSSIIPISMRVNVDVGRIWYAYVIGKDDKIPGTVARNTNIPEELGRLQYLFADKTGTLTKNIMNFRFIQVGSDTVLNYHEVDRFQSSIAAYFGENYVPRGTNTVDSGKINSHSTQRNFTRDVTSVGEAIVSLVLCHNVTPVVEDGCLQYQASSPDEVAFVNFCRSLGVTLTHRDVTCMQFTTPGGRLVHYDIIKTFPFTSERKCMGIILREKVDSESVSCGANSDGVYKYFMKGADFKMTSVVRSSSWLEESCQEFAQVGLRTLVFAQRQLTKEQVDTFLARYDEANADLSEARDSLLDAAMALIERDMKLIGVTGVEDELQDDVTTSLETLGMGGIKVWVLTGDKVETAITIGRATRLIPRHGKIEVMSCRTEEETQRYLDSLYLQYYNSMNDAPLDVPWTLVLDGGRLSMCLTKATSKTFVRVARLAYSVIVSRCSPTQKAEVVRTMKKFTSRNIRTAAIGDGGNDVGMILAADVGIGVEGVEGKQASMAADFSIAKFSHCVRLIMWHGRSSYRRTCNMSQFVIHRGMAYSVVQAFYSLLFAGTSMSVFNGYLLMGYSTIFTMAPVFALVLDEDVKEGDVREFPQLYKELLKSRSMNTRSYLQWLWISVFQGGTMIYLALALFGKEMFQITTVAYTTLLLTELVIVAGTLHLRILWTQRRKHLYYFVAAECFSIVTFLLAVLLLPDMIDQDYLFSWSCAWQVFVISLAIVIPIYLIRLLDTYILSNARMK
Protein: DNA mismatch repair protein MLH2 (MutL protein homolog 2) (Q07980)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of a MutL heterodimer with MLH1, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a role in the repair of heteroduplex sites present in meiotic recombination intermediates and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA mismatch repair protein MLH1
- MutS protein homolog 5
- MutS protein homolog 4
- DNA mismatch repair protein MSH6
- DNA mismatch repair protein MSH3
- DNA mismatch repair protein MSH2
- DNA mismatch repair protein PMS1
- DNA mismatch repair protein MLH3
- DNA mismatch repair protein MSH1, mitochondrial
- DNA repair protein RAD10
Sequence:
MTIHQLSPESQWKIVSSSFIYGPVAAVRELLDNSIDSGAKKVFIDVDSTTGGCEYISVKDDGSGVDIIDRPSMCLEYTTSKMSSLGDISILTTLGFRGEALFLLSNLCNQKGSMQVETKTADDVIGEKWLVDSKGGITNGKRYKVSCPVGTTVILRKLLGGLRARYLEISSRPRKTFDELIYLINHYSLIHRNIRFYFSLVSLQKNGAIERKQMQETLDPKISRARSLSLLARLKKPVPLNFIVEENFVIDEKINLDLILPRMVPESDVINIKRRFKFLSVNERALSLNLETGKTISKLLSSIYRDFSLLDPMVWFINLNCDTKLLDVNIEPEKNDVMIKSFEVIFKKIENKLKLLLEERIGIETNMLGDKHVQPSINEKTSPALVIPTPDAENEISKGCGAVSGKDKTDIPQKNSDLIVPTFYDEANLENTTIVAATPSPTKFSEDKALDEQTQLTISSYRSSSSGSMASEDSTNWRHNFQQELSENSEVAGAGSSTLPSSLTYNYIETIPENEDLELSKDASISNPFMITKIRNVNKKLSENLLEAKRTSCGDANKRGMPNERQLSNTEKKELIKLQQTYGKRNNTVDMTIPRNSKKKVTDNYIKKASCMHKTRPKLMHFSEYTNNYVYTLKNEKIVKHDSDNFAKETLWLRSRDDATSPSSSLLQALRAHVKKPGHIEATTNEWCLFTPDSP
Protein: GTP-binding protein (Q5A779)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Zinc finger CCCH domain-containing protein 15
- Gir2p
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL2
- 60S acidic ribosomal protein P0
- Small ribosomal subunit protein uS19
- Protein transport protein SSO2
- DNA polymerase epsilon subunit B
- Citrate synthase
Sequence:
MTTVEKIKAIEDEMAKTQKNKATSFHLGQLKAKLAKLRRELLSEGSGSGGGGAGVGFDVARTGVATVGFVGFPSVGKSTLLSKLTGTHSEAAAYEFTTLTTVPGTIKYKGAKIQMLDLPGIIEGAKDGKGRGRQVIAVARSVNLIFLVLDVNKPLQHKKIIEHELEGMGIRINKEPPNIVITKKDKGGINITNTVPLTHLDNDEIRAVMSEYKINSANIAFRCDATVDDLIDAIEAKARKYIPAIYVLNKIDSFSIEELNLLAKIPDAIPISSANGWNLDDLLQMMWDKLKLVRVYTKPKGKLPDFNEPVVLRSDRCTVEDFCNSIHKSLVEDFRNALVYGTSVKHQPQIVGLNHQLEDEDVITILKK
Protein: C-type mannose receptor 2 (Lectin lambda) (Macrophage mannose receptor 2) (CD antigen CD280) (Q64449)
Organism: Mus musculus (Mouse)
Function: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Secretory phospholipase A2 receptor
- Macrophage mannose receptor 1
Sequence:
MVPIRPALAPWPRHLLRCVLLLGGLRLGHPADSAAALLEPDVFLIFSQGMQGCLEAQGVQVRVTPVCNASLPAQRWKWVSRNRLFNLGATQCLGTGWPVTNTTVSLGMYECDREALSLRWQCRTLGDQLSLLLGARASNASKPGTLERGDQTRSGHWNIYGSEEDLCARPYYEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPGEENCGVIRTESSGGWQNHDCSIALPYVCKKKPNATVEPIQPDRWTNVKVECDPSWQPFQGHCYRLQAEKRSWQESKRACLRGGGDLLSIHSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGRLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQVIYSDARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFRWLSGDEVIYTHWNRDQPGYRRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWVSDPKLRHCYKVFSSERLQEKKSWIQALGVCRELGAQLLSLASYEEEHFVAHMLNKIFGESEPESHEQHWFWIGLNRRDPREGHSWRWSDGLGFSYHNFARSRHDDDDIRGCAVLDLASLQWVPMQCQTQLDWICKIPRGVDVREPDIGRQGRLEWVRFQEAEYKFFEHHSSWAQAQRICTWFQADLTSVHSQAELDFLGQNLQKLSSDQEQHWWIGLHTLESDGRFRWTDGSIINFISWAPGKPRPIGKDKKCVYMTARQEDWGDQRCHTALPYICKRSNSSGETQPQDLPPSALGGCPSGWNQFLNKCFRIQGQDPQDRVKWSEAQFSCEQQEAQLVTIANPLEQAFITASLPNVTFDLWIGLHASQRDFQWIEQEPLLYTNWAPGEPSGPSPAPSGTKPTSCAVILHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAATPPAPGAELSYLNHTFRLLQKPLRWKDALLLCESRNASLAHVPDPYTQAFLTQAARGLQTPLWIGLASEEGSRRYSWLSEEPLNYVSWQDEEPQHSGGCAYVDVDGTWRTTSCDTKLQGAVCGVSRGPPPRRINYRGSCPQGLADSSWIPFREHCYSFHMEVLLGHKEALQRCQKAGGTVLSILDEMENVFVWEHLQTAEAQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSSSGLWRPGACTNITMGVVCKLPRVEENSFLPSAALPESPVALVVVLTAVLLLLALMTAALILYRRRQSAERGSFEGARYSRSSHSGPAEATEKNILVSDMEMNEQQE
Protein: SEPALLATA1 (Q5XXN8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSSSNMLKTLDRYQKCSYGSIEVNNKPAKELENSYREYLKLKGRYENLQRQQRNLLGEDLGPLNSKELEQLERQLDGSLKQVRSIKTQYMLDQLSDLQNKEQMLLETNRALAMKLDDMIGVRSHHMGGGGGWEGGEQNVTYAHHQAQSQGLYQPLECNPTLQMGYDNPVCSEQITATTQAQAQQGNGYIPGWML
Protein: Kinesin-like protein (Q4GZ84)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Kinesin-like protein
- Kinesin-like protein
- Kinesin-like protein
- Kinesin-like protein, putative
- Kinesin-like protein
Sequence:
MQTSRPSADNVHVSCRFRPLSSGERNGGLCVHLEGSNHVVCRVQSCQRLGRSNGAPRQQPIPCNSVGGDGFNRFPSADTAVDQYRFSFARVYPPEVGQDEIYNEVARPIVKDVMKGYNGTLLVYGQTGSGKTHTMFGAGEAVGRERSGTISTALYGTAGDDRGPVRAQGGRANVNAGIIPRAVNQIFDMIHSADEALEFEIRAMFVEVYMERVRDLLDHGNLNLQVREGPSGFYVENCKLPYVSSAEEMMQLINSGVCRRVTAATACNEASSRSHCVLNITVKSVNHTKHVATVGKLFLVDLAGSEKVAKTHVDGMQLEEAKMINKSLTTLGHVIMSLADKQAHVPYRDSKLTRILKDSLGGNSRTALVVCCSPSQFNDQETLSTLRFGARAQNVCNVAIVNKQLTAEELKGMLDLARVEIKRLRKLLHDMGVTVPSSGNHGGEEISDCFSGVAESSCGGETFATRVASPCDTAVPGPHSEASAVGHLEETDAVINADGVVDESSVNEGDVVRRGIYDELSGEGISPEVSHLHDNPCVSQGTTEAIRNQLAEQAALIKLLREENAVWEEEHMIAVRELYGYRRYAEHCREVLGEVSITGDVVSRRISSYRERVLAIVAKLCSHSDTTEDNLATQSNEYPNQIKEGRSLVELGATRETCSSVSNNLSQPLLSSHISSRTTMCSLPALGDGTAGNNNTITGSMELACASVESPNGDTLQIRKKYEELQGRLARAMDEIERLQSTNSVLSLDLQLAEKRLQIRHERIESLKFGLRQESASNQELQQSLERQMSAHRTQLQAARNDALYWRQRYDDLLNHCHTSSSSRKPRATHISPIRRRSLTPTLEGVLVARSPSARAPPSSVATSPGRGVIVKPIRGGGSKLEHAFA
Protein: Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) (Q8MPP2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
Sequence:
MTEFQAVVFAAGRGTRLPEVLGDAPKCLLPVGPYPLIWYPLNLLQQHNFSEVIVVVLEQEKLEIQSALENTPLKLRLDYATIPSDGDFGTADSLRYIYDKIKSDFLVVSCDLVSNVSLYPLINKFREHDAALAMLLFPSGFESDVVMPGPKSKHKPERDLIGIHAATQRLAFVSAASDCEETLNIQRHLLKNRGRLDVYSRLVDAHVYVLKKWIIDYLRRKENISTFKGEFLPHLIKKQHSKRPPKTVQDTTSEVGVVTKNEDHVLHYVGHTILDQKITQTSLFNQSLSQSPYHGDIVRCYGIQAPRDAIGVRVNNTLSFLAINRKLASIWNNLCGEKHPLISPGAVVKSTQTKEIIAADNAKLSEKTSLNFSVFGPNCIISPKNIVANSLIMSNAIVEEGCNIDNCIIGHRAQVKSGSVLKNCIIGPNYVVEEGTHSQAVHLSNADQFMEIDIQ
Protein: C2 domain-containing protein At1g53590 (N-terminal-TM-C2 domain type 6 protein 1) (NTMC2TYPE6.1) (Q93XX4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Filament-like protein
- Haloacid dehalogenase-like hydrolase
- Transmembrane protein, putative
- Protein NETWORKED 2D
- At5g54130
- At1g64330
- At3g45160
- Protein PELPK1
- F3M18.16
- Heavy metal-associated isoprenylated plant protein 25
Sequence:
MESSLIHHIIIVLLLLWFISSLNRSHAFFYFLALIYLYLVHERYVMRLKRKLQFEERKQANQRRVLSDSESVRWMNYAVEKIWPICMEQIASQKILGPIIPWFLEKYRPWTAKKAVIQHLYMGRNPPLLTDIRVLRQSTGDDHLVLELGMNFLAADDMSAILAVKLRKRLGFGMWTKLHLTGMHVEGKVLIGVKFLRRWPFLGRLRVCFAEPPYFQMTVKPIFTHGLDVAVLPGIAGWLDKLLSIAFEQTLVQPNMLVVDMEKFVSPTSENWFFVDEKEPVAHVLVEVFEASDLKPSDLNGLADPYVKGKLGAYRFKTKIQKKTLSPKWHEEFKIPIFTWDSPSILNIEVGDKDRFVDDTLGECSVNIEEFRGGQRNDMWLSLQNIKMGRLHLAITVIEDNAKSSDDPLKKAKLNKEDIQTSFASDTTNLGSFSSDKSPSVVDNFEPIKIDGQEETAIWVQKPGAEVSQIWEPRKGKSRRLDSQIQRTPNDESLSNGSSSTDDNQEGSKNPMKSVGRGLRKIGSMFHRNVKKEEFLIGSIEEESQSQSPRINLKAVNQKDVGLNFIVDDNLSGPLSGKSLDGESLDAEENSGKGHMKDVAKSFLKQAEKSAKQIKHAFSRKGSMKPRDGHKEIVPESDSGTDSESSDDDDAFTCVKNLATEPGKLTRDGNIERTGDDDHVDSTTLATAKEDSSGDILEDSTDVEAKEEKLKEAAESETRDMDTAMNIKTEDEKGDTLKNIEEGEEKESSSK
Protein: Cyclin-dependent kinase-like 5 (D3ZG85)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Methyl-CpG-binding protein 2
- Protocadherin-19
Sequence:
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSTKRKPYHVESSTLSNRSQSTKGGALQTHHRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSSTRSQQNRHSFMESSQSKAGTLQPSEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETNTSRYFPSSCLDLNSPTSPTPTRHTDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGIDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARPSVKESSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSDSSSGTNHSKRQPGFDPWKSPENISHSDQLKEKEKQGFFRSMKKKKKKTQTVPNTDGPDLLTLQKAIHSSSTASSRPKEWRPEKLSDLQTQSQPLKSLRKLLHLSSSTNHPASSDPRFQPLTAQQAKNSFSEIRIHPLSQASGGSSNIRQEPTPKGRPALQLPDSPTYWFPGPQPQRTYWLHKRRVAKTFVER
Protein: Cyclin pch1 (Pombe cyclin C homolog 1) (O74627)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for progression through the whole cell cycle.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Probable cyclin-dependent kinase 9
- CTD kinase subunit gamma
- CTD kinase subunit alpha
- Transcription elongation factor spt5
- Serine/threonine-protein kinase crk1
- CTD kinase subunit beta
- DNA-directed RNA polymerase II subunit rpb1
- Cell division control protein 73
- Transcription elongation factor spt4
- Cyclin mcs2
Sequence:
MSEVIKSVPPGSQNTSQWIISKDQLVFTPSALDGIPLDQEEIQRSKGCNFIINVGLRLKLPQTALATANIYFHRFYLRFSLKNYHYYEVAATCIFLATKVEDSVRKLRDIVINCAKVAQKNSNVLVDEQTKEYWRWRDVILYTEEVLLEALCFDFTVEHPYPYVLSFIKKFVADDKNVTKVAWTYINDSTRSIACLLYSPKTIAAAAFQFALEKNEINLSTTTDGLPVWMEESQVSYEDVKGVLTLIDSLYKKINPSKQALPIDQKNGSHASSVAPGTPSSLASVSTQATPQHQNSSGRTDSFHSLNTETPSKSTVDDQILSTAAQPKKSSDTDKEMETEAS
Protein: Pcsk6 protein (Q99LE4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
TGRSPAQCLSCRRGFYHHQETNTCVTLCPAGLYADESQRLCLRCHPSCQKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELVKCGECHHTCRTCVGPSREECIHCAKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCEENCLSCEGSSRNCSRCKAGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG
Protein: E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR) (Q96EP1)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Subcellular location: Nucleus, PML body {ECO:0000269|PubMed:11912157, ECO:0000269|PubMed:15467728, ECO:0000269|PubMed:18172500}.
Interaction partners:
- Aprataxin and PNK-like factor
- Poly [ADP-ribose] polymerase 1
- Aprataxin
- Ubiquitin-conjugating enzyme E2 D2
- E2 ubiquitin-conjugating enzyme
- Serine/threonine-protein kinase PLK1
- DNA repair protein XRCC1
- DNA ligase 3
- Ubiquitin-conjugating enzyme E2 D1
- Ubiquitin-conjugating enzyme E2 N
Sequence:
MERPEEGKQSPPPQPWGRLLRLGAEEGEPHVLLRKREWTIGRRRGCDLSFPSNKLVSGDHCRIVVDEKSGQVTLEDTSTSGTVINKLKVVKKQTCPLQTGDVIYLVYRKNEPEHNVAYLYESLSEKQGMTQESFEANKENVFHGTKDTSGAGAGRGADPRVPPSSPATQVCFEEPQPSTSTSDLFPTASASSTEPSPAGRERSSSCGSGGGGISPKGSGPSVASDEVSSFASALPDRKTASFSSLEPQDQEDLEPVKKKMRGDGDLDLNGQLLVAQPRRNAQTVHEDVRAAAGKPDKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMERSSLCPTCRCPVERICKNHILNNLVEAYLIQHPDKSRSEEDVQSMDARNKITQDMLQPKVRRSFSDEEGSSEDLLELSDVDSESSDISQPYVVCRQCPEYRRQAAQPPHCPAPEGEPGAPQALGDAPSTSVSLTTAVQDYVCPLQGSHALCTCCFQPMPDRRAEREQDPRVAPQQCAVCLQPFCHLYWGCTRTGCYGCLAPFCELNLGDKCLDGVLNNNSYESDILKNYLATRGLTWKNMLTESLVALQRGVFLLSDYRVTGDTVLCYCCGLRSFRELTYQYRQNIPASELPVAVTSRPDCYWGRNCRTQVKAHHAMKFNHICEQTRFKN