wanglab/gogpt-training-data huggingface dataset:
Protein: RBR-type E3 ubiquitin transferase (EC 2.3.2.31) (Q54DM8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Suppressor of smlA
- Uncharacterized protein DDB_G0289357
- Aspartyl aminopeptidase
- Uncharacterized protein DDB_G0286393
- Uncharacterized protein
- Carbohydrate-binding domain-containing protein
- Suppressor of smlA
Sequence:
MAHNKNTEDSLFLVVDNPDNRKRFTVTFNKNENEKETIVIIIPPTTTFSKFLGLLISKFKLEASSRAHIRVKANGSTRIKSLTNTYNNQLIEFSLSELADEDPEDKNQLTESQELQLQLKEKEEKLKSIENSYLPLYSKREHNKSKFYKKVINKLQSSQGELFKVIVGESYPYRCKVLIQKLEKDSRIWVYFTETLNENENNNNNNNNNENDDDDNNNNNNNNNNNNNNNNNNNNNNNNKNNNNNNNNFSYTFDTEIQLGRLDKNGNQKKEDIIKILENQYKIDKTNIIGAILDIESYYRREFYTTQNFGVLDKCVNLFVDLEKISTVSQNKLIENCYNSIEKVSKHFDIPNSLSKKLLFQSGWNEKKSIGIPSNREQNRSFIRNSHFSHKVNDIAMYKFKLIDESNSQDFECSICYCDYSKSDMVELICGHSFCKRCLSHYFKTSVCDGNGSSSPIVCPSQGCLNKCIDEVTIETLLQPNMVSVFLKNFIKDVIFLTPNTHECPFNNCNRVVLGLRGTHKYIPYIACSDHDLFCLFCKKRGMHWPLPCSHSAYDDHDLFSYRWIIANTTICSKCKFPVERNQGCNHMTCIRCHHQFCYSCGSDYPHTGGCSSGGSSKEHKIKLFFKAVGDKNMSMDGAFLREFFERDPFTNSDPVINHVYKSFITIITGKSYTSKQHLRLLESAIFFLHSHSISTKKSESDHLMDSCQKAIKKLLRPDILADKTCFLSPYYSSQKQGPSEISLSATICKNGSKKSLGKLFVNTHFHDFKQEISNLLNKSIPSDQVEYDPKKIRLFNLYGGQIKSSSDIINNEPIFITTSIHEQFIEPQIPTLTLEEIEEAQKQIELENKNNVKILVDQKEKVFTQLKPKNKRMNDTLKLRENLENQLKLQEKLKIDQENLGNPNVQLFTDEIRDQYFYYRTTLLDSDNDDSDEYYYYDDSDEYEQYNAKDLIDHPTSNDTTTVTTTTATTTTTATEESIIIDGEDEFVNIDSNSSSSEFEDGDEDLLEIKRLQEIDDQVLEKENQLIVQEQKQIDLVFKVLEMYQDEKFGLDFDKVFSVCSDSKNLSQAIKKMTNYLDENYYSNQYGITQTYLLIKERLSFTFPNLSLTVIDRAIKESKYNHDKAKSWIYNKFQKQQKKKFNQLSKNNQQQQQQQQQPQSQQQPQLQTRKINTSEQFEIESEDDDSYDIDEAENYLTEKIYNDKVSKFHHKMD
Protein: Type IB DNA topoisomerase small subunit (Q7Z011)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MSSVNSEVRNGGSSSVAAAQPRAASPAKIPVKVPYSLAKVPMPRLVPAKMPAPKRAAESEAQHRGNREDSDDALLESSAPSKKPKKEESKKAPLVETESSSSSEYSSSDSDDTDASDSESEGSKTSTVSDSSDISDDEESVSEDNLTFFELAERSGLMNDIKNKVNSGEGEQEEEEEVHIDGKPPRPKFLRSFPRDIEAEIGKHEKRLKDVENMLKMKQDNKTVSLGTSKVNYIDPRIVCSWANENNVPISRLFSATLQKKFPWALKARDFTF
Protein: Ankyrin repeat domain-containing protein 26 (Q9UPS8)
Organism: Homo sapiens (Human)
Function: Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.
Interaction partners:
Sequence:
MKKIFSKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVRTGNRTLFEDRDSDSQDEVVVESLPTTSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKEEPTKPGIAKKENGIDIIESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAELESGSIASPLGSTDESNLNQDLVWKASREYVQVLKKNYMI
Protein: Histone-lysine N-methyltransferase Su(var)3-9 (EC 2.1.1.355) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (Lysine N-methyltransferase 1) (Protein suppressor of variegation 3-9) (P45975)
Organism: Drosophila melanogaster (Fruit fly)
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation.
Subcellular location: Nucleus. Chromosome, centromere. Chromosome {ECO:0000269|PubMed:26389589}. Note=Associates with centromeric constitutive heterochromatin.
Interaction partners:
- Heterochromatin protein 1
- Histone H3
- Histone H3.3A
- Histone deacetylase HDAC1
- Chromosomal serine/threonine-protein kinase JIL-1
- DNA damage-binding protein 1
- Protein suppressor of variegation 3-7
- Calmodulin-lysine N-methyltransferase
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase
- Heterochromatin protein 1c
Sequence:
MATAEAQIGVNRNLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLERLSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYETYIAKITTELEKQLEALPLMENITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCGRDNCRKVLF
Protein: Probable serine/threonine-protein kinase PBL3 (EC 2.7.11.1) (PBS1-like protein 3) (Protein kinase 2B) (O49840)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in plant defense signaling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21219905}; Lipid-anchor {ECO:0000305|PubMed:21219905}. Nucleus {ECO:0000269|PubMed:21219905}. Note=Predominantly localized at the plasma membrane. {ECO:0000269|PubMed:21219905}.
Interaction partners:
- Expressed protein
- Rho GTPase-activating gacO-like protein
- Multiple C2 domain and transmembrane region protein 16
- Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 1, mitochondrial
- Serine carboxypeptidase-like 27
Sequence:
MGNCLDSSAKVDSSSHSPHANSASLSSRVSSKTSRSTVPSSLSINSYSSVESLPTPRTEGEILSSPNLKAFTFNELKNATRNFRPDSLLGEGGFGYVFKGWIDGTTLTASKPGSGIVVAVKKLKTEGYQGHKEWLTEVNYLGQLSHPNLVKLVGYCVEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAIGAAKGLTFLHDAKSQVIYRDFKAANILLDAEFNSKLSDFGLAKAGPTGDKTHVSTQVMGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELLSGRRAVDKSKVGMEQSLVDWATPYLGDKRKLFRIMDTRLGGQYPQKGAYTAASLALQCLNPDAKLRPKMSEVLAKLDQLESTKPGTGVGNRQAQIDSPRGSNGSIVQKSPRRYSYDRPLLHITPGASPLPTHNHSPRVR
Protein: High mobility group B protein 15 (Nucleosome/chromatin assembly factor group D 15) (Q9MAT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds preferentially DNA with A/T-rich content.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000255|PROSITE-ProRule:PRU00355}.
Interaction partners:
- Actin-related protein 4
- At3g01890
- SWI/SNF complex component SNF12 homolog
- Histone deacetylase complex subunit SAP18
- Chromatin structure-remodeling complex protein BSH
- Histone H4
- Actin-related protein 9
- Actin-related protein 5
- Chromatin structure-remodeling complex protein SYD
- Actin-related protein 4A
Sequence:
MASSSCLKQGSVPMNNVCVTPEATYEAVVADPRLFMTSLERLHSLLGTKFMVPIIGGRDLDLHKLFVEVTSRGGINKILNERRWKEVTATFVFPPTATNASYVLRKYYFSLLNNYEQIYFFRSNGQIPPDSMQSPSARPCFIQGAIRPSQELQALTFTPQPKINTAEFLGGSLAGSNVVGVIDGKFESGYLVTVTIGSEQLKGVLYQLLPQNTVSYQTPQQSHGVLPNTLNISANPQGVAGGVTKRRRRRKKSEIKRRDPDHPKPNRSGYNFFFAEQHARLKPLHPGKDRDISRMIGELWNKLNEDEKLIYQGKAMEDKERYRTEMEDYREKKKNGQLISNAVPLQQRLPEQNVDMAEADLPIDEVEEDDEEGDSSGSSGESEPHDDQSIETDPELEEPSLNPSGPNLNPNPTEIVVAPKEKNGDVVMETSPLKKADEPTVAVTAEQN
Protein: mRNA-binding protein PUF2 (Pumilio homology domain family member 2) (Q12221)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of COX17 by binding to the 3'-UTR of COX17 mRNA. Promotes decay of COX17 mRNA by enhancing its rate of deadenylation and subsequent turnover. Predominantly binds to mRNAs encoding membrane-associated proteins with roles in transmembrane transport and vesicular trafficking.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15024427}. Note=Localizes to foci enriched near the periphery of the cell.
Interaction partners:
- Protein NAM8
- U1 small nuclear ribonucleoprotein A
- Protein WHI3
- RNA-binding protein MRN1
- Pumilio homology domain family member 6
- Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
- Uncharacterized protein YBL081W
- Protein ZEO1
- Heterogeneous nuclear rnp K-like protein 2
- KH domain-containing protein YLL032C
Sequence:
MDNKRLYNGNLSNIPEVIDPGITIPIYEEDIRNDTRMNTNARSVRVSDKRGRSSSTSPQKIGSYRTRAGRFSDTLTNLLPSISAKLHHSKKSTPVVVVPPTSSTPDSLNSTTYAPRVSSDSFTVATPLSLQSTTTRTRTRNNTVSSQITASSSLTTDVGNATSANIWSANAESNTSSSPLFDYPLATSYFEPLTRFKSTDNYTLPQTAQLNSFLEKNGNPNIWSSAGNSNTDHLNTPIVNRQRSQSQSTTNRVYTDAPYYQQPAQNYQVQVPPRVPKSTSISPVILDDVDPASINWITANQKVPLVNQISALLPTNTISISNVFPLQPTQQHQQNAVNLTSTSLATLCSQYGKVLSARTLRGLNMALVEFSTVESAICALEALQGKELSKVGAPSTVSFARVLPMYEQPLNVNGFNNTPKQPLLQEQLNHGVLNYQLQQSLQQPELQQQPTSFNQPNLTYCNPTQNLSHLQLSSNENEPYPFPLPPPSLSDSKKDILHTISSFKLEYDHLELNHLLQNALKNKGVSDTNYFGPLPEHNSKVPKRKDTFDAPKLRELRKQFDSNSLSTIEMEQLAIVMLDQLPELSSDYLGNTVIQKLFENSSNIIRDIMLRKCNKYLTSMGVHKNGTWVCQKIIKMANTPRQINLVTSGVSDYCTPLFNDQFGNYVIQGILKFGFPWNSFIFESVLSHFWTIVQNRYGSRAVRACLEADSIITQCQLLTITSLIIVLSPYLATDTNGTLLITWLLDTCTLPNKNLILCDKLVNKNLVKLCCHKLGSLTVLKILNLRGGEEEALSKNKIIHAIFDGPISSDSILFQILDEGNYGPTFIYKVLTSRILDNSVRDEAITKIRQLILNSNINLQSRQLLEEVGLSSAGISPKQSSKNHRKQHPQGFHSPGRARGVSVSSVRSSNSRHNSVIQMNNAGPTPALNFNPAPMSEINSYFNNQQVVYSGNQNQNQNGNSNGLDELNSQFDSFRIANGTNLSLPIVNLPNVSNNNNNYNNSGYSSQMNPLSRSVSHNNNNNTNNYNNNDNDNNNNNNNNNNNNNNNNNNNNNSNNSNNNNNNDTSLYRYRSYGY
Protein: UPF0524 protein C3orf70 homolog A (Q1LY84)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in neuronal and neurobehavioral development. Required for normal expression of neuronal markers elavl3 and eno2 and neurobehaviors related to circadian rhythm and changes in light-dark conditions.
Interaction partners:
- Iroquois homeobox 3b.
Sequence:
MAASGGQKSEKLDEAQALARSCAGRPDFLPCDGLSICATHSHGKCFKLHWCCHLGWCHCKYVYQPMTSVCQLPSTAVPVAPSGHTHTMNLSISLAERFLRTAPKFQAPPCPESPKFCVISDLFVDDYMVKRINGKMCYVQRPPPPTPNPTHQPQTAAPQPVPQRSKNSHQVGPTVKQGQAKEKISAPKMDHCSSPSSSEDSGINALGLHYMESCDEDSCVDDDDEEEEDDELSTDGNSSPGSFWDQDECTLLSPSKSIVEIIEKIETTV
Protein: Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein (Q385I7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSARGSQQQSTATASIPLNLSFGNFDFDETKRLGQRGGGVRELAKSLRRAQRQAAAHSQMLKNRGGLEQRNAELLGTAMRRAAGERVKDDPKRLAKALAKRRSKKRTSARKWAGRLEQIQQSVDNVVEDRATTRAKKRRVGKTGGDSGKKKAAKTFGDKGNRKGNNKKGRRGGGVGPSTGKKGRVGGFAKKGAAPTGKKGRPKGSK
Protein: RNA polymerase-associated protein RTF1 homolog (G5EBY0)
Organism: Caenorhabditis elegans
Function: Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.
Subcellular location: Nucleus {ECO:0000269|PubMed:24721716}. Note=Localization is independent of the other PAF1 complex components. {ECO:0000269|PubMed:24721716}.
Interaction partners:
- RNA polymerase II-associated factor 1 homolog
- Cell division cycle protein 73
- RNA polymerase-associated protein CTR9
- RNA polymerase-associated protein LEO1
- Suppressor of Ty 6 homolog
- Transcription elongation factor SPT5
- Transcription elongation factor SPT4
- FACT complex subunit spt-16
- FACT complex subunit SSRP1-A
- FACT complex subunit ssrp1-B
Sequence:
MSSSESASSDEETKRRAPATSDSDSDSDAGPKPGKPLSTDSSASDSDAEKPQAKPAKKKTLTKRKRRATGSSDDDQVDDDLFADKEDKARWKKLTELEKEQEIFERMEARENAIAREEIAQQLAKKAKKSSEKGVKTEKRRKMNSGGSDAGSPKRKASSDSDSEMDAAFHRPSDINRKHKEKNAMDALKNKRKEIEKKNAKNEALSIDAVFGANSGSSSSSSSSESSRSSSSSRESSPERVSEKDKIVKKDVDGLSELRRARLSRHKLSLMIHAPFFDSTVVGCYVRLGQGQMSGSGSKYRIWKIVGVEESNKVYELEGKKTNKIIKCQNGGSERPFRMQFVSNADFEQIEFDEWLLACKRHGNLPTVDIMDKKKQDIEKAINHKYSDKEVDLMIKEKSKYQTVPRNFAMTKANWSKQKELAQQRGDIREAEQIQTKIDEIERQADELEKERSKSISAIAFINHRNRSKIKDQVLSGQLKIEENSQDDPFTRKKGGMRVVSGSKSRLDGTLSASSSTTNLSDGGKDKSSSLAKPTQPPPSTQIKKKTDISSLHDFDLDIDLGKLKDFSTPESSGNKRPSISSSKGVSLSDYRMRRSGGGDAGSSTSAAPSSAV
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (CI-B9) (NADH-ubiquinone oxidoreductase B9 subunit) (Q02371)
Organism: Bos taurus (Bovine)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:18721790}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 1
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
Sequence:
MAERVAAFLKNVWAKEPVLVASFAIAGLAVILPTLSPYTKYSLMINRATPYNYPVPLRDDGNMPDVPSHPQDPQGPSLEWLKRL
Protein: Synaptotagmin-2 (NTMC2T1.2) (Synaptotagmin B) (B6ETT4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play an important role in regulating an unconventional protein trafficking from the cytosol to the extracellular matrix.
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:22140429}; Single-pass membrane protein {ECO:0000305|PubMed:22140429}.
Interaction partners:
- RNI-like superfamily protein
- Sugar transport protein 11
- Protein SPEAR1
- HVA22-like protein j
- Probable acyl-activating enzyme 9
- MEI2 C-terminal RRM only like 2
- Non-specific lipid-transfer protein 11
Sequence:
MGIISTILGVIGFGFGTTIGIVIGYYLFIYFQSTDVEDPEIKPLVELDSETIATMFPEIPMWVKNPDFDRIDWLNKLIGHMWPYMDKAICKMAKSIAKPIIAEQIPNYKIDSVEFEMLTLGSLPPSFQGMKVYATDDKEIIMELSVKWAGNPNIIVVAKAFGLKATVQVIDLQVYATPRITLKPLVPSFPCFANIFVSLMDKPQVDFGLKLLGADVMAIPGLYRFVQEIIKDQVANMYLWPKTLNVQIMDPSKAMKKPVGLLSVKVIKAIKLKKKDLLGGSDPYVKLTLSGDKVPGKKTVVKHSNLNPEWNEEFDLVVKEPESQELQLIVYDWEQVGKHDKIGMNVIQLKDLTPEEPKLMTLELLKSMEPKEPVSEKSRGQLVVEVEYKPFKDDDIPENIDDPNAVEKAPEGTPSTGGLLVVIVHEAEDLEGKYHTNPSVRLLFRGEERKTKRVKKNREPRWDEDFQFPLDEPPINDKLHVEVISSSSRLIHPKETLGYVVINLGDVVSNRRINDKYHLIDSKNGRIQIELQWRNSS
Protein: Serine/threonine-protein kinase SRK2D (EC 2.7.11.1) (OST1-kinase-like 3) (Protein ATHPROKIN A) (SNF1-related kinase 2.2) (SnRK2.2) (Q39192)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with SRK2I, key component and activator of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as seed germination, Pro accumulation, root growth inhibition, dormancy and seedling growth, and, to a lesser extent, stomatal closure. In response to ABA, phosphorylates the ESCRT-I complex component FREE1, which is required for ABA-induced FREE1 nuclear import.
Interaction partners:
- Protein phosphatase 2C 56
- Protein phosphatase 2C 77
- Protein phosphatase 2C 37
- Protein phosphatase 2C 16
- Probable protein phosphatase 2C 75
- ABSCISIC ACID-INSENSITIVE 5-like protein 7
- ABSCISIC ACID-INSENSITIVE 5-like protein 5
- ABSCISIC ACID-INSENSITIVE 5-like protein 6
- Protein ABSCISIC ACID-INSENSITIVE 5
- Probable protein phosphatase 2C 78
Sequence:
MDPATNSPIMPIDLPIMHDSDRYDFVKDIGSGNFGVARLMTDRVTKELVAVKYIERGEKIDENVQREIINHRSLRHPNIVRFKEVILTPSHLAIVMEYAAGGELYERICNAGRFSEDEARFFFQQLISGVSYCHAMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEILLRQEYDGKLADVWSCGVTLYVMLVGAYPFEDPQEPRDYRKTIQRILSVTYSIPEDLHLSPECRHLISRIFVADPATRITIPEITSDKWFLKNLPGDLMDENRMGSQFQEPEQPMQSLDTIMQIISEATIPTVRNRCLDDFMADNLDLDDDMDDFDSESEIDVDSSGEIVYAL
Protein: Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein P-OTX) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) (Pituitary OTX-related factor) (P70314)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Can independently activate and synergize with PIT-1 on pituitary-specific target gene promoters, thus may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs. Can activate pituitary transcription of the proopiomelanocortin gene.
Subcellular location: Nucleus.
Interaction partners:
- T-box transcription factor TBX4
- Steroidogenic factor 1
- Pituitary-specific positive transcription factor 1
- T-box transcription factor TBX19
- Early growth response protein 1
Sequence:
MDAFKGGMSLERLPEGLRPPPPPPHDMGPSFHLARAADPREPLENSASESSDADLPDKERGGEAKGPEDGGAGSAGCGGGAEDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQPYEDVYAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSMGPGAVPGMPNSGLNNINNLTGSSLNSAMSPGACPYGTPASPYSVYRDTCNSSLASLRLKSKQHSSFGYGGLQGPASGLNACQYNS
Protein: Protein DEHYDRATION-INDUCED 19 homolog 2 (AtDi19-2) (Q8GWK1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16786289}. Nucleus {ECO:0000269|PubMed:16786289}.
Interaction partners:
- GPN-loop GTPase QQT1
- U11/U12 small nuclear ribonucleoprotein 31 kDa protein
- U11/U12 small nuclear ribonucleoprotein 48 kDa protein
- Geranylgeranyl transferase type-2 subunit beta 2
- Glutamate receptor 3.7
- Cysteine proteinase inhibitor 2
- Calcium-dependent protein kinase 1
- Ras-related protein RABG2
- U11/U12 small nuclear ribonucleoprotein 65 kDa protein
- Sodium/hydrogen exchanger 6
Sequence:
MEDDMWCVSSSGSSRSYRSETAAKYQSGPYQDLEEFEEVDDDIAVEYPCPFCASDYDLVELCHHIDEEHRHEANNGICPVCSKRVKMHMVDHITSHHRDVLKSEQKEMSYREDPYLSDKYLQPHLDELPPSMNHHQHPSKHVSDQFLSFINNSALPNQTKLVLPDSSVEDKNPIKDSSAAKEGTSSCPLSDSDKLEKAKKCEFVQGLLSSAMFDDECDSSE
Protein: Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactoside galactohydrolase) (Alpha-galactosidase 27A) (Melibiase) (B3PGJ1)
Organism: Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Function: Hydrolyzes galactomannan found in plant cell wall, by cleaving alpha-1,6-D-galactose side-chains from the mannan backbone. Appears to act in synergy with mannanase (ManA) to elicit hydrolysis of galactomannan. Has greater activity against galactomannans with decreased degree of polymerisation values. To a lesser extent, is also able to degrade other galactosides containing alpha-1,6-linked D-galactose, such as melibiose and stachyose.
Interaction partners:
- Beta-galactosidase, putative, bgl2C
- Beta-galactosidase, putative, bgl2B
- Beta-galactosidase, putative, bgl2A
- Alpha-glucosidase, putative, adg97A
- Alpha-glucosidase, putative, adg97B
- Aldose 1-epimerase
- Alpha glucosidase, putative, glc13A
- Alpha amylase, putative, amy13B
- Oligo-1,6-glucosidase, putative, glu13A
- 4-O-beta-D-mannosyl-D-glucose phosphorylase
Sequence:
MRKQLLLGLGLVSALLVSVQASAQKFEQLAKTPQMGWNSWNTFGCNVDEKMIRAMADAMVTSGMKAAGYEYINIDDCWHGERDKNGFIQADKKHFPSGMKALADYVHAKGLKLGIYSDAGNTTCAGRPGSRGHEYQDALTYASWGIDYVKYDWCDTQDINPKSAYATMRDAIHKAGRPMLFSICEWGDNQPWEWAQDVGHSWRTTGDIYPCWNCEHNHGSWSSFGVLPILDKQAGLRKYAGPGHWNDMDMMEVGNGMTEEEDRAHFSLWAFMASPLIAGNDLRNMSDTTRAILTHKETIAINQDKLGIQAMKWIDEGDLEIYIKPLEKGHYAVLFLNRADDAMDYRFDWSFHYMKDDISKHEIFFDKQAFNWRNIWNGETGSTKEVLNIKVPAHGVVVLRLSPR
Protein: Cytochrome B pre-mRNA-processing protein 6 (O43089)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in processing of the 5' terminus and the intervening sequences of cytochrome b pre-mRNA.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- CBP3-like protein
- Protein atp12
- Protein mss51
- Protein atp11
- Cytochrome b translation regulator cbp8
Sequence:
MSLNQKITKAVALWPKDELRPWLSFPKTLDTSIRARLQKMPPQQANKQLNALNNLLDNVYWNKYIPKQVVLKPQFKPSYYESLTQIRRKEEKAPLWKRLFKRK
Protein: Cathelicidin-derived antimicrobial peptide 1 isoform c (A0A0F6QDT7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MKMKVQVRSLILLAVAVLQVRSQNQTETRYEDIILVALPQLLPGEEQAFRPILNQLQVKTLNTEDVDQSEVSVRLTFPIQETFCSKSQGQPGKPCPLKKNGKLMMCSMKVRHPILEASNNLNTDLSTFVCEYMDAEDALQQKIRTRRSKVRICSRGKNCVSRPGGGSFNDEFIRDHSDGNRFA
Protein: 5,10-methenyltetrahydromethanopterin hydrogenase (EC 1.12.98.2) (H(2)-dependent methylene-H(4)MPT dehydrogenase) (H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase) (N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase) (Q02394)
Organism: Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Function: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
Interaction partners:
- F420-dependent methylenetetrahydromethanopterin dehydrogenase
- Methenyltetrahydromethanopterin cyclohydrolase
- Serine hydroxymethyltransferase
- 5,10-methylenetetrahydromethanopterin reductase
- Uncharacterized protein conserved in archaea
- Uncharacterized protein conserved in archaea, FLPA ortholog
- Predicted enzyme related to biotin synthase
- Carbon monoxide dehydrogenase
- Glutamate--ammonia ligase
- Uncharacterized protein conserved in archaea
Sequence:
MVEINKVAILGAGCWRTHAATGITTFKRACEVADETGIKEAALTHSSVTYAVELKHLAGVDEVVLSDPVFDADGFTVVDIEEDCDVDLDEFIKAHLEGNPEDVMPKLRDYVNDIADDVPKPPKGAIHFLSPEEMEDKLDIVVTTDDAEAVEDADMIISWLPKGGVQPDIFKKIIDDIPEGCIVANTCTIPTRQFKEMFEDMGRDDLQVTSYHPATVPEHKGQVFVAEGYADEEVVEAVYELGEKARGLAFKVPGYLLGPVCDMASAVTAIVYAGLLTFRDACTDILGAPVDFTQNMAVEALQMMAKFMEEEGLDKLEEALDPAALTNTADSMNFGPLADTEILPKALEVLEKYSKKAE
Protein: MYND-type domain-containing protein (Q384A3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGCQQSGVRMSPQDLSDRTPSGQHGFTGDASNTALPTVPTDSWYGKNFSETSRMAFTEFHLKQRGNIVFAGTPVPVGASELGEFPGNSPPLLTRAVIGKDNVYGMAYLYSTPLSIEHQWRLRVCHYQIACSPSGQTLGEVPGALSTLPETPTTDEQKIRLWNFAKQVYDRPLCDTFVGIKVYVDGELVPDRYPRAKSLPNCTATLESSEVFNNWTCVPFVLVGYVNSPMISTVTMYRHLSLSFVEYLLGKTITGGETDRTKDEEVAECKDENTVGDGRSVDAPDKPKEEVTQSFNVSVEVVYGCEAEMNFCTAHIAKGNIELVMGEHSDAALRKYKASLEEFLRKSGNERHQVVAVDPLTLKGRNSALWTCLFCGSPLQFTCTICGAELCGMSSCVWKPFTGYPLGCSSHKAQA