wanglab/gogpt-training-data huggingface dataset:
Protein: Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53) (F4JIE1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03154}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03154}.
Interaction partners:
Sequence:
MFSSFTCCDGREEVIQAWYMDDSEEDQRLPHHKDPKEFLSLDKLAELGVLSWRLDADNYETDEDLKKIRESRGYSYMDFCEVCPEKLPNYEVKVKSFFEEHLHTDEEIRYCVAGSGYFDVRDRNEAWIRVWVKKGGMIVLPAGIYHRFTVDSDNYIKAMRLFVGEPVWTPYNRPHDHLPARKEYIDNFVKVNEGGVIDASA
Protein: GTP-binding protein, putative (Q38E75)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL3m
- Ribosomal protein L11, putative
- 50S ribosomal protein L13, putative
- Large ribosomal subunit protein mL43
- 50S ribosomal protein L17, putative
- KOW domain-containing protein
- Large ribosomal subunit protein bL21m
- Acyl carrier protein
Sequence:
MRRGLTCRNVHDPVFMRNVKRVLASYKESMDHSSRKGMSREAFVDINEKGAAWYLGHMQLASRTLAEKVKDADFVLEIRDARLPFTTGNPNLQKIIIDRPRLIVFNKAEMSNEDCNRVIQQYYERTGNFALFTSAKRSWRDTVEAVQRFVTHILPAQRFKTTANVGLVVGMPNVGKSTLINSLRLAHEYQFHREDFRRPRTPEAVSIAPGTTRGVKLVPVCKDPNIVLYDSPGLTLPGCFAKEAGLKLAACGIIPTNDITLPRSLVARYIYDVLSAAGVGEHMAECLHLPRAPISFDDCISMICERSGTSGQTDLGNLDPSRAQKFLIHDFQLGNLGRITLDKLPNKVRQAVSGKEYQRIGGGAGSGTEASNEENEVVWTHDVKSSDVVARYSEEMREVMEELQGEPVENTPSNRKPCGDSTVISRKKGPISRVSAHDESFRRSIRIIPGR
Protein: Pericardine (Q9U617)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLPFRLGLLLGAVLFVASANGAVIENEVSSLNDLQREKRSGRGYSRGQTQSQYLNFGKPEEDGKAEAEATENGSRSTVSGTHGMGQAQSQFSSGDCNGCSGYQTDYPSSGRILDASGSGGIGRPDSIISLPGGVGGQTGAGQPGYGSQPGIGGQTATGQPGYGSQLGVGAQAGAGQPGYGAQPGVGAQTGAGQPGYGSQTGIGGQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPGIGGQTGAGQPGYGTQPGIGGQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPGIGGQTGAGQPGYGTQPGIGGQTGAGQPGYGTQPGIGGQTGPGQPGYGTQPGIGGQTGPGQPGYGSQPGIGGQTGAGQPGYGTQPGIGGQTGAGQPGYGTQPGIGAQTGAGQPGYGTQPGIGGQTGAGQPGYGTQPGIGVQTGAGQPGYGSQPGIGAQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPGIGGQTGAGQPGYGTQPGIGAQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPGIGGQTGAGQPGYGTQPGVGAQTGTGQPGYGSQPGVGTQIGAGQPGYGSQPGIGGQTGAGQPGYGSQPGIGGQTGAAQPGYGTQPGVGAQTGTGQPGYGAQPGIGGQTGAGQPGYGRQPGIGGQTGPGQPGYGTQPGVGTQTGTGQPGYGAQPGIGGQSGAGQPGYGSQPGIGGQTGGGQPGYGSQIGGQTGAGQPSYGSQPGVGAQNGGGQPGYGTRPVIGGQTGAGQPGYGGQTGVGGSPGFLTQPGIGGISGPIGGKVGGGQSEAAKPGYWAQPGIGGPSRYGSQPGIGDQTGAGQSGYGGQPGISGQTGGGQPGYGGQATISGLPGYGTQPGIGALTAVPGGHYGYETQPGIGGQTGTNQPGFGGQPGIGGQTGAGQPGYGFIGQPGIGGQTGTSGRQPGYGTQPGIGGQTAAGQPGYGSQPGIGGQTGAGQPGYGSQTGVGGQIGAGQPGYGSQPGIGGQTGAGQPGYGAQPGFGGQPGYGNQPGVGGQTGAGQPGYGSQPGVGGQTGAGQPGYGVIPGFGGQPGIGGQTAAGKPGYGGQPGIGGSPVYGTQQGTGGPSGISGGQPGYGTQPGQTGAGQPGYGSLPGTGGQATAGQPGYGPGSQPGIGGAPVYGTQPGGGGQTGVIGGQPGQIGDRVGQPGYGTQTGQIGAPGRYTDGSQTVPGAVGTGGVVAAGTSGADDAFSQAESSIGDGQASASAQGKKNGGTAKTQVSGTYSSGGTFSASAMTSDADRAASAQVTGNADGAVSQSQGSGGPAQSQAQVQVAKDGGTKASSQSGGIIQQSQSEVHANDKGGLADAQSSGPGQTSSQAQIGFRPGQEANPIAANGGGQASSSSGTHSSQSSSQIHGTSSFGVSYHGAAQSASGTKEQVATYREANRELFNTISQFGNNANAVTDRADAVYSGPALTDESDRVPEAQLKSTKPKEEAEQVVSKPDHPEPVQYDDEDEADPDEYDEDEYYEEKPVKLEESPKSSTIVAPTEATPRPKTYNQSSPTQSQQTVVVPVPGEKYQVVQKQNGKATINAEPSTTEAIPPGFRGTVNVEKKFHTKALELHAPKGVEITPDTSDEGPVRGDKPLRRAPDSYVTVTKSVTGSMDNTKNPPQENKNFQSTYYTKSSTCGYFTFSCNIVYGANGRSKICRPKAPTNGKC
Protein: Bone morphogenetic protein 2 (BMP-2) (Q90751)
Organism: Gallus gallus (Chicken)
Function: Negatively regulates the structure and function of the limb apical ectodermal ridge.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- receptor protein serine/threonine kinase
- Bone morphogenetic protein receptor type-1B
- Activin receptor type-1
- Activin receptor type-2A
- Activin receptor type-2B
- Bone morphogenetic protein receptor type-2
- Uncharacterized protein.
- Neuroblastoma suppressor of tumorigenicity 1
- Runt-related transcription factor
- TGF_BETA_2 domain-containing protein.
Sequence:
GSLKRPEDLLGEFELRLLHMFGLKRRPSPGKDVVIPPYMLDLYRLHAGQQLGYPLERAACRANTVCSFHHEEVLEELPETSGKTARRFFFNLTSIPNEESVTSAELQIFPGEQVHEAFESNSSYHHRINIYEIMKPATATSKDPVTRLLDTRLVHHNASKWESSDVTPAVLRWIAHGQPNHGFVVEVVHLDKENSASKRHVRISRSLHQDEDSWSQLRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRHKYSCKRHPLYVDFNDVGWNDWIVAPPGYSAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Protein: Histone H2A (D3ZXP3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003767}.
Interaction partners:
- Histone H3
- Histone H4
- Breast cancer type 1 susceptibility protein homolog
- Serine-protein kinase ATM
- E3 ubiquitin-protein ligase RNF168
- CHK2 checkpoint homolog
- Histone H2B
- TP53-binding protein 1
- X-ray repair cross-complementing protein 6
- Mediator of DNA damage checkpoint protein 1
Sequence:
MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTSATVGPKAPAGGKKASQASQEY
Protein: E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1) (F8W2M1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q8IYU2}. Cytoplasm {ECO:0000250|UniProtKB:Q8IYU2}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IYU2}.
Interaction partners:
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MERAMEHLNVQLNRLTRSLRRARTVELPEDSETAVYTLMPMVMADQHRSVSELLLNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKRGANPNYQDISGCTPLHLAARNGQKKCMGRLLEYNADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTNVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDRNGVTPLDLCVQGGYGETCEILIQHHGRLFQTLIQMTQNDDIKENMLRQVLEHVSQQNDSNYQRILTSLAEVATTNGHKLLSLSSNFEVQTKSLLRIIRIFCHVFCLGPSSPNNGNDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLISTELEKEITDTTRSSSGNDIASLFLKKQEVDHSVSSENPQLLLDASSVMKTPEVYADGQDVISMIANRLSAVIQAFYMCCSCQMPHGMTSPRFIEFVCKHDEVLKCFVTRNPKIIFNHFHFLLECPELMSRFMHIIKGQPFKDRCEWFYEHLLAGQPDSDMVHRPVNENDILLVHRDSLFRSSCEVVSKSSNEKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIINPDYALFTQSADGTTFQPNSNSSVNPDHLNYFRFAGQILGLALYHRQLVNIYFTRSFYKHILGIPVSYQDVSSIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGTMEEVPLKPGGTTIQVTQDNKEEYVQLVTELRMTRAIQPQINAFLQGFHTFIPPSLIQLFDEYELELLLSGMPEIDVMDWKRNTEYTSGYDLQEPVIQWFWEVVENLTQEERVLLLQFVTGSSRVPHGGFAFLMGGSGLQKFTVAAVPYTSNLLPTSSTCINMLKLPEYPSKDVLRDRLLVALHCGSYGYTMA
Protein: Berberine bridge enzyme-like 23 (AtBBE-like 23) (EC 1.1.1.-) (Q9FKV2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:18796151}.
Interaction partners:
- rhamnogalacturonan endolyase
- Glycoside hydrolase family 28 protein / polygalacturonase
- Pectin lyase-like superfamily protein
- Peroxidase 43
- Alkaline-phosphatase-like family protein
- Peroxidase 36
- Peroxidase 69
- Aspartyl protease family protein At5g10770
- Peroxidase 33
Sequence:
MRTLEAFALSLFLVFLVKWVNSDSSSSPSKDQFLSCMSTHSDSSFINPKSFIHKPDSRVYTDFSQSLISQNYRFLTLNFTSQKPILIVTPRTDTEIQRSLLCSRKLGVKVRTKSGGHDYEGLSYLSLHSPFIILDLVNVRSIEINLADETAWVGAGATIGELYYKIAKSSKIHGFPAGTCPSVGVGGHFSGGGFGAMMRKHGLAADNVVDARFVDANGRIYNSRREMGEDLFWAIRGGGAASFGVVLSWKVKLVRVPEKVTCFRRNLPLTQNMTKIVHRWQQIAAELDDNLFIRVIVSISGGSVQTTFQANYLGGIDKLIPLMNQKFPELGLTFQDCSEMTWIDSIMYFNWKKGQPLETLLDRGQRYNDLYFKAKSDFVKNPIPEIGLEGIWTRFHEVESPIMIMEPLGGKMYEIGETETPFPHRRGNLYNIQYMVKWRLKDIGVMEKHVTWMRLLYRYMRVYVSASPRGAYLNYRDLDLGMNRGVNTSFEDAKLWGFRYFGSNFKRLAIVKGKIDPTNFFRNEQSVPPLIV
Protein: Low-affinity glucose transporter HXT4 (Low-affinity glucose transporter LGT1) (P32467)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Low-affinity glucose transporter. Can also transport xylose.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein.
Interaction partners:
- High-affinity hexose transporter HXT7
- Low-affinity glucose transporter HXT3
- High-affinity hexose transporter HXT6
- Probable glucose transporter HXT5
- High-affinity glucose transporter HXT2
- Low-affinity glucose transporter HXT1
- Carbon catabolite-derepressing protein kinase
- Glucose transport transcription regulator RGT1
- Protein STD1
- Regulatory protein MIG1
Sequence:
MSEEAAYQEDTAVQNTPADALSPVESDSNSALSTPSNKAERDDMKDFDENHEESNNYVEIPKKPASAYVTVSICCLMVAFGGFVFGWDTGTISGFVAQTDFIRRFGMKHHDGTYYLSKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVPLGLGFAWALFMIGGMTFVPESPRYLVEVGKIEEAKRSIALSNKVSADDPAVMAEVEVVQATVEAEKLAGNASWGEIFSTKTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLEDSFETSIVLGIVNFASTFVGIFLVERYGRRRCLLWGAASMTACMVVFASVGVTRLWPNGKKNGSSKGAGNCMIVFTCFYLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPFISGAIDFYYGYVFMGCLVFSYFYVFFFVPETKGLTLEEVNTLWEEGVLPWKSPSWVPPNKRGTDYNADDLMHDDQPFYKKMFGKK
Protein: Cell division protein FtsZ (P73456)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00909}. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane. {ECO:0000255|HAMAP-Rule:MF_00909}.
Interaction partners:
- Cell division protein SepF
- Sll0446 protein
- Probable septum site-determining protein MinC
- Penicillin-binding protein
- Probable peptidoglycan glycosyltransferase FtsW
- Protein translocase subunit SecA
- Protein RecA
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- Chromosomal replication initiator protein DnaA
- Sll1632 protein
Sequence:
MTLNNDLPLNNIGFTGSGLNDGTEGLDDLFSSSIVDNEPLEALVETPTFASPSPNLKRDQIVPSNIAKIKVIGVGGGGCNAVNRMIASGVTGIDFWAINTDSQALTNTNAPDCIQIGQKLTRGLGAGGNPAIGQKAAEESRDEIARSLEGTDLVFITAGMGGGTGTGAAPIVAEVAKEMGCLTVGIVTRPFTFEGRRRAKQAEEGINALQSRVDTLIVIPNNQLLSVIPAETPLQEAFRVADDILRQGVQGISDIIIIPGLVNVDFADVRAVMADAGSALMGIGVGSGKSRAKEAATAAISSPLLESSIQGAKGVVFNVTGGTDLTLHEVNVAAEIIYEVVDADANIIFGAVIDDRLQGEMRITVIATGFNGEKEKPQAKTSSKPVLSGPPAGVETVPSTTTPEDPLGEIPMAPELDIPDFLQKRRFPRR
Protein: Ras-related protein RSR1 (EC 3.6.5.2) (P13856)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Ras-related protein which binds GDP/GTP and possesses intrinsic GTPase activity. Involved in development of cell polarity during the cell division cycle, and essential for bud emergence.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Inhibitory regulator protein BUD2/CLA2
- Cell division control protein 24
- Bud emergence protein 1
- Bud site selection protein 5
- Cell division control protein 42
- Rho-type GTPase-activating protein 1
- Guanine nucleotide exchange factor LTE1
- GTPase-interacting component 2
- Serine/threonine-protein kinase CLA4
- GTPase-interacting component 1
Sequence:
MRDYKLVVLGAGGVGKSCLTVQFVQGVYLDTYDPTIEDSYRKTIEIDNKVFDLEILDTAGIAQFTAMRELYIKSGMGFLLVYSVTDRQSLEELMELREQVLRIKDSDRVPMVLIGNKADLINERVISVEEGIEVSSKWGRVPFYETSALLRSNVDEVFVDLVRQIIRNEMESVAVKDARNQSQQFSKIESPSTRLPSSAKQDTKQSNNKQSSKGLYNKSSQGQAKVKQSTPVNEKHKPSHAVPKSGSSNRTGISATSQQKKKKKNASTCTIL
Protein: Thromboxane A2 receptor (Prostanoid TP receptor) (D7R7W5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MSHNRSAGCLMSSNVCNGSCPKREVSVTSTGISMTVGIVSNTLALFILIKAYHRFRYKSKAAFLLFASGLVITDFLGHLINGSLALYVYVSQKEWETFDNHKSLCDFFGVCMAFFGLTPLLLGCLMAVERCIGVTRPLFHTTALGSHHVKRLLGVTWLLGLLVALLPVLFQRSYQVQRSRSWCFFRLQGPRDWMDTLLPILFSALGLLALLVSLLCNTMTFLTLLRSRVQLDRNNHRHSRKASHHSEMVCQLLAIMLVSCVCWGPILITAIIFSLQDRGEDQTSYTHMLLVVRMATWNQILDPWVYILLRKAVLRRLFKVALRLCSRHLKFTFQWQSSNLGSSTMEASSSVISRPDFTPLDGTFLPDTAIKLAHLPRASLGDTRSQFTDI
Protein: Weary, isoform B (Q7KU08)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RAC serine/threonine-protein kinase
- CHOp24, isoform A
- 14-3-3 protein zeta
- Delta-like protein
Sequence:
MWKIYVLTLVIAVVAATTSETITNDLTAKSNRTLLKTSTEESREISALGGSTSTATPTTTATTSTTTTRATTVAEDEMEETSTPTPTTVRLMTTTQKMVQANLGEIGSIKDALHRIKLSEKPVDGATTTTEQPEAMDQDEQDEQDVTPTISPLQIQMQAAASYQVAETLADLNEEERARYDAMLAQQPTASKLNIVDLYPLKIEDIQPIIRNDNDELIKQRTVFTQHENAEEYKQNLMPNEVEMMVDKEVIEMKDKIQINQEKFGSSTTVKPTTSRPHQGTTADFTGKLLADQDDLITEIESKFQLHETTTLRPRVTTVQHPGNTFIDRRVKKSFEFPMQHRASDVMAMPHIDFANTKFQTDADAPNPPASHPEFSTTKFYNSKELYNEMLLHNKRKLMKAAKAEGSPIKSAEDTTRATSSNVTPEGKTFGPTTTTAAGSTATTTAESTTTAATTTRLPATTTGKYQKELKRAKLLLKALTPPKSVDKSTASPSSTTSTSTSTTTTMATLLATARTRPSAANPTKTASKPIARPRILSRLQEKINSLECEIPNVPQDSHLWRGNETHELLLPIVTTEHCKPDEHCVPNVLTWRGEAEIQSGDILIVEINDAMLNPSHEPNNTSSAVHATQVYQVTRSGHEHCDVTEGVLLDITPLVVDGRKLVTLYDKDLTEGVNLLIVVSELWGAQCVRLKVTTKTDNCGENADCSGKGVCYSNSGMEEYECQCCSGFAGPHCEEIDACNPSPCTNNGICVDLSQGHEGNSYQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCVHGICVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNPCTHGGTCWSSGDSFYCACRPGYTGTMCEDEFVVETVVSSSEFIVDDANARNFNDKTFGSSVVLKSPIELHNAYFAAGVLAAAIFIVAVVVTICHCKVNQTYRKFSTRSTSFIPILGFSRRPKVQGKLNKHWLSGKGATATSSTNIVAPPGGPRAGGAAGPQQVTRHLPGQPQTQTTLGGQLQERPFLRHLAMNLENDMYYTVDFSENSQHSPLIQ
Protein: Diadenylate cyclase (DAC) (EC 2.7.7.85) (Cyclic-di-AMP synthase) (c-di-AMP synthase) (Diadenylate cyclase CdaA) (Q8Y5E4)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Function: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes. Expression of truncated proteins (missing first 80 or 100 residues) in E.coli leads to c-di-AMP synthesis.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01499}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01499}.
Interaction partners:
- Lmo2119 protein
- Phosphoglucosamine mutase
- Arginine repressor
- Lmo1871 protein
Sequence:
MDFSNMSILHYLANIVDILVVWFVIYKVIMLIRGTKAVQLLKGIFIIIAVKLLSGFFGLQTVEWITDQMLTWGFLAIIIIFQPELRRALETLGRGNIFTRYGSRIEREQHHLIESIEKSTQYMAKRRIGALISVARDTGMDDYIETGIPLNAKISSQLLINIFIPNTPLHDGAVIIKGNEIASAASYLPLSDSPFLSKELGTRHRAALGISEVTDSITIVVSEETGGISLTKGGELFRDVSEEELHKILLKELVTVTAKKPSIFSKWKGGKSE
Protein: Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK pathway associated phosphatase) (JKAP) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) (Q9NRW4)
Organism: Homo sapiens (Human)
Function: Activates the Jnk signaling pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20553486}.
Interaction partners:
- Ras-related C3 botulinum toxin substrate 3
- PDZ and LIM domain protein 4
- Espin
- Dihydropyrimidinase-related protein 3
- CD2-associated protein
- Unconventional myosin-Ic
- Unconventional myosin-Ia
- Junctional adhesion molecule C
- Unconventional myosin-VI
- Myosin-IIIa
Sequence:
MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAAPGILKFWAFLRRL
Protein: Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) (Q6ZUJ8)
Organism: Homo sapiens (Human)
Function: Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Tyrosine-protein kinase SYK
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 3-kinase regulatory subunit gamma
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- B-lymphocyte antigen CD19
- Growth factor receptor-bound protein 2
- Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
Sequence:
MAASGVPRGCDILIVYSPDAEEWCQYLQTLFLSSRQVRSQKILTHRLGPEASFSAEDLSLFLSTRCVVVLLSAELVQHFHKPALLPLLQRAFHPPHRVVRLLCGVRDSEEFLDFFPDWAHWQELTCDDEPETYVAAVKKAISEDSGCDSVTDTEPEDEKVVSYSKQQNLPTVTSPGNLMVVQPDRIRCGAETTVYVIVRCKLDDRVATEAEFSPEDSPSVRMEAKVENEYTISVKAPNLSSGNVSLKIYSGDLVVCETVISYYTDMEEIGNLLSNAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEEDMMTNQRDEELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDMLKSHIKEELMHGEEADAVYESMAHLSTDLLMKCSLNPGCDEDLYESMAAFVPAATEDLYVEMLQASTSNPIPGDGFSRATKDSMIRKFLEGNSMGMTNLERDQCHLGQEEDVYHTVDDDEAFSVDLASRPPVPVPRPETTAPGAHQLPDNEPYIFKVFAEKSQERPGNFYVSSESIRKGPPVRPWRDRPQSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKQTDLEITVPIRHSQHLPAKVEFGVYESGPRKSVIPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEVTRSRSPGPPQVDGTPTMSLERPPRVPPRAASQRPPTRETFHPPPPVPPRGR
Protein: Uncharacterized protein (Q57XL4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPTVQPCRWDNKTLPYVPEQPCLLYYLIPGDDVSHMAVPNARGEYPNLIPGMPYLEELLLELDNEEEIEDNAVLPLVEYAPPPLTADAGVQVEWTDVPIPPPPHMMRYVKPLTETTQSVTGSDCSPSTTQEFGGED
Protein: Heat shock protein 60, mitochondrial (CPN60) (P66) (Stimulator factor I 66 kDa component) (P19882)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:11502169}.
Interaction partners:
- 10 kDa heat shock protein, mitochondrial
- Import motor subunit, mitochondrial
- ATP-dependent molecular chaperone HSP82
- ATP-dependent molecular chaperone HSC82
- GrpE protein homolog
- Heat shock protein SSC3, mitochondrial
- Heat shock protein 78
- Endoplasmic reticulum chaperone BiP
- T-complex protein 1 subunit alpha
- Heat shock protein 104
Sequence:
MLRSSVVRSRATLRPLLRRAYSSHKELKFGVEGRASLLKGVETLAEAVAATLGPKGRNVLIEQPFGPPKITKDGVTVAKSIVLKDKFENMGAKLLQEVASKTNEAAGDGTTSATVLGRAIFTESVKNVAAGCNPMDLRRGSQVAVEKVIEFLSANKKEITTSEEIAQVATISANGDSHVGKLLASAMEKVGKEGVITIREGRTLEDELEVTEGMRFDRGFISPYFITDPKSSKVEFEKPLLLLSEKKISSIQDILPALEISNQSRRPLLIIAEDVDGEALAACILNKLRGQVKVCAVKAPGFGDNRKNTIGDIAVLTGGTVFTEELDLKPEQCTIENLGSCDSITVTKEDTVILNGSGPKEAIQERIEQIKGSIDITTTNSYEKEKLQERLAKLSGGVAVIRVGGASEVEVGEKKDRYDDALNATRAAVEEGILPGGGTALVKASRVLDEVVVDNFDQKLGVDIIRKAITRPAKQIIENAGEEGSVIIGKLIDEYGDDFAKGYDASKSEYTDMLATGIIDPFKVVRSGLVDASGVASLLATTEVAIVDAPEPPAAAGAGGMPGGMPGMPGMM
Protein: High-affinity zinc uptake system protein ZnuA (P39172)
Organism: Escherichia coli (strain K12)
Function: Involved in the high-affinity zinc uptake transport system.
Subcellular location: Periplasm {ECO:0000250|UniProtKB:A1B9L0}.
Interaction partners:
- Metal-binding protein ZinT
- Zinc import ATP-binding protein ZnuC
- High-affinity zinc uptake system membrane protein ZnuB
- Murein DD-endopeptidase MepM
- Zinc transporter ZupT
- Molybdate-binding protein ModA
- Vitamin B12-binding protein
- Zinc/cadmium/lead-transporting P-type ATPase
- Large ribosomal subunit protein bL31B
- Nickel-binding periplasmic protein
Sequence:
MLHKKTLLFAALSAALWGGATQAADAAVVASLKPVGFIASAIADGVTETEVLLPDGASEHDYSLRPSDVKRLQNADLVVWVGPEMEAFMQKPVSKLPGAKQVTIAQLEDVKPLLMKSIHGDDDDHDHAEKSDEDHHHGDFNMHLWLSPEIARATAVAIHGKLVELMPQSRAKLDANLKDFEAQLASTETQVGNELAPLKGKGYFVFHDAYGYFEKQFGLTPLGHFTVNPEIQPGAQRLHEIRTQLVEQKATCVFAEPQFRPAVVESVARGTSVRMGTLDPLGTNIKLGKTSYSEFLSQLANQYASCLKGD
Protein: Bacterial microcompartment shell protein EutM (Bacterial microcompartment protein homohexamer) (BMC-H) (Ethanolamine utilization protein EutM) (P0ABF4)
Organism: Escherichia coli (strain K12)
Function: Probably a major component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation (Probable). Each homohexamer has a central pore with an opening of up to 8.6 Angstroms. A positively-charged funnel leads to the pore from each side of the hexamer; a phosphate or sulfate ion is found in the pore. The pore probably allows metabolite passage into and out of the BMC.
Subcellular location: Bacterial microcompartment {ECO:0000250|UniProtKB:P41791}.
Interaction partners:
- Bacterial microcompartment shell vertex protein EutN
- Bacterial microcompartment shell protein EutS
- Bacterial microcompartment shell protein EutL
- Ethanolamine utilization protein EutJ
- Acetaldehyde dehydrogenase
- Acetate kinase EutQ
- Probable acetate kinase EutP
- Ethanolamine ammonia-lyase reactivase EutA
- Probable ethanolamine permease EutH
- Ethanolamine ammonia-lyase small subunit
Sequence:
MEALGMIETRGLVALIEASDAMVKAARVKLVGVKQIGGGLCTAMVRGDVAACKAATDAGAAAAQRIGELVSVHVIPRPHGDLEEVFPIGLKGDSSNL
Protein: Axoneme-associated protein mst101(1) (Q08695)
Organism: Drosophila hydei (Fruit fly)
Function: Possible structural role in the sperm tail. It is associated with axonemal structures.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MSFLSRFVCAVPRQAIFRTFSTLTGSSGCKYLPESTFNTIQKVSFCKKSAKGKDGDLKKKCAEAAKKEKEAAEKKKCAEAAKKEKEAAEKKKCAEAAKKEKEAAEKKKCAEAAKKEKEAAEKKKCAEAAKKEKEAAEKKKCAEAAKKEKEAAEKKKCAEAAKKEKEAAEKKKCAEAAQKKKCAELAKKEQEAAEKKKCAEAAKKEKEAAEKKKCEERAKKEKEAAEKKKCEERAKKEKEAAEKKKCAEAAKKEKEAAEKKKCAEAAQKKKCAELAKKAKEAAEKKKCAKKAGEKGSKQSGSDKGKKNGKKNDMKNKCAMLAKKAKEEALKKKCAAAQKKCEPKK
Protein: 2',5'-oligoadenylate synthetase-like 7 (Q8VI96)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MARELFITPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMGGSYDEHNALKGRSEANMVVFFNDLTSFEDQLKWQQVFIEEIRKHLLQLQQEKPCKLKFEVQSSEEPNTRSLTFKLCSPERQQEVEFDVQPAYDALYEGGYCKSFESINYNKVYAQLIHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEFGVQDSFGLHAAQCFRTVLELVTKYKCLLIYWTWFYDFRPEISDYLHGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWIHSNFFRNCDMSLVNGWEVSPEKQ
Protein: FI19868p1 (Q9VZP2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Cyclin J, isoform A
Sequence:
MVAAKYERLNTSGEAAGNGNGNASDAEDEEIELHLAQKTQLGNGHRLRQSNFKYASGKCGSGEAPCTNETATLAQENMMMQMAVGTLAIIFLYLALSISLTFYQTDINRQMPFPLAIVTYHLVVKFLLAAAARRIYRMRVGRSRVQLDWRLALRKMAPTGVASAIDIGFSNWGLALVPISLYTMTKSSTIVFILLFAIAFGLEKKSWYLVSIVGLIGTGLLMFTYKSTDFNALGFFFILFASLSSGLRWSFAQFIMQKSKLGLHNPIDMIYYMQPWMIASLVPLVIGIEGAGLIAVIEDLHNHTSNEITWAIARISAGALLAFLMEFSEFLVLCKTSSLTLSIAGIFKDICQLALAVTIRKDHLSVINYIGLIICLAGIVCHLLHKYSNMKEMQRQQELQLDNDQEESSPGEYKFNDGSAIVGVHVKSHSTLTVPLLEQTDSEDESGASNKQNASDVIFDVLKRRDMQR