wanglab/gogpt-training-data huggingface dataset:
Protein: Keratin-associated protein 9-9 (Keratin-associated protein 9-5) (Keratin-associated protein 9.5) (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9) (Q9BYP9)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
Sequence:
MTHCCSPCCQPTCCRTTCCRTTCWKPTTVTTCSSTPCCQPSCCVSSCCQPCCRPACCQNTCCRTTCCQPTCLSSCCGQTSCGSSCGQSSSCAPVYCRRTCYYPTTVCLPGCLNQSCGSSCCQPCCRPACCETTCCRTTCFQPTCVSSCCQPSCC
Protein: RNA-binding protein 3 (RNA-binding motif protein 3) (Q925G0)
Organism: Rattus norvegicus (Rat)
Function: Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed (By similarity). Enhances phosphorylation of translation initiation factors and active polysome formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:17403028}. Cytoplasm {ECO:0000269|PubMed:17403028}. Cell projection, dendrite {ECO:0000269|PubMed:17403028}. Note=Localizes in mRNA granules in dendrites. Isoform 1 shows a much higher dendritic localization than isoform 2.
Interaction partners:
Sequence:
MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQRSRGFGFITFTNPEHASDVMRAMNGESLDGRQIRVDHAGKSARGTRGGAFGAHGRGRSYSRGGGDQGYGSGRYDSRPGGYGYGYGRSRDYSGSQGGYDRYSGGNYRDNYDN
Protein: Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (p85SPR) (Q9ES28)
Organism: Mus musculus (Mouse)
Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
Subcellular location: Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
Interaction partners:
- Cell division control protein 42 homolog
- ARF GTPase-activating protein GIT1
- Serine/threonine-protein kinase PAK 3
- Paxillin
- ARF GTPase-activating protein GIT2
- Serine/threonine-protein kinase PAK 1
- Serine/threonine-protein kinase PAK 2
- Proto-oncogene tyrosine-protein kinase Src
- Protein scribble homolog
- Rho guanine nucleotide exchange factor 12
Sequence:
MNSAEQTVTWLITLGVLESPKKTISDPEVFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRNESECLSNIREFLRACGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSSHSRTSKLLQSQYRSLDMTDNTNSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLRPLQTSDKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCTSQQDLHEWVEHLQKQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSSLSRLEPSDLSEDSEYDSIWTAHSYRMGSASRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL
Protein: Transglycosylase (E7DNA3)
Organism: Pneumococcus phage Dp-1 (Bacteriophage Dp-1)
Interaction partners:
Sequence:
MKRVKKTKLMTKKKNKLNNQPKKESTQTFKVNCDHCEHKFDLTSKQIISKHIEKGVEWRFFECPKCHYRFTTYVGNKEIENLIRFRNTCRAKMKQELQKGAAANQNTYHSYRIQDEQAGHKISGLMAKLKKEINIEKREKEWVSI
Protein: Response regulator MprA (Mycobacterial persistence regulator A) (P9WGM9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region. MprB/MprA is involved in regulation of numerous stress-responsive genes, including up-regulation of two sigma factors, sigE and sigB as well as pepD and mprA, and repression of multiple genes from regulons associated with hypoxia, starvation and iron metabolism. The majority of genes regulated by MprB/MprA under a particular stress condition are different from those induced during normal growth, but several genes are commonly regulated under more than one condition.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Signal transduction histidine-protein kinase/phosphatase MprB
- Sensor-like histidine kinase SenX3
- Sensor-type histidine kinase PrrB
- Sensor histidine kinase component HK1
- Sensor histidine kinase TrcS
- Probable sensor histidine kinase TcrY
- MoaB/Mog domain-containing protein
- histidine kinase
- Sensor histidine kinase MtrB
- RNA polymerase sigma factor SigB
Sequence:
MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRGTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
Protein: F420H(2)-dependent reductase Rv1155 (EC 1.-.-.-) (O06553)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'-phosphate (PLP), the anti-tuberculosis drug PA-824 or aflatoxin analogs as substrates.
Interaction partners:
- Conserved protein
- Conserved protein
- Conserved protein
- Conserved protein
- F420H
- Deazaflavin-dependent nitroreductase
- Putative F420H
Sequence:
MARQVFDDKLLAVISGNSIGVLATIKHDGRPQLSNVQYHFDPRKLLIQVSIAEPRAKTRNLRRDPRASILVDADDGWSYAVAEGTAQLTPPAAAPDDDTVEALIALYRNIAGEHSDWDDYRQAMVTDRRVLLTLPISHVYGLPPGMR
Protein: Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Overlapping meiotic transcript 2) (Pterin carbinolamine dehydratase) (PCD) (O42658)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in spore wall formation.
Subcellular location: Spore wall {ECO:0000269|PubMed:12786945}. Note=Inner spore wall.
Interaction partners:
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Sporulation-specific protein spo7
- Probable glucoamylase
- Anaphase-promoting complex subunit 14
- Vacuolar segregation protein 7
- Hypoxanthine-guanine phosphoribosyltransferase
- Meiotic expression up-regulated protein 31
Sequence:
MNTSARLLALVSKSKNNWILQQGDTKLFKSFRFKNFIEAWGFMSCVALRAQQLNHHPEWTNVYNKVDITLTTHDTKGLTEKDLKLAEFIDTLAKDN
Protein: Homeodomain protein HOX1 (A9Z0X3)
Organism: Gossypium arboreum (Tree cotton) (Gossypium nanking)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MTNPPTKDFFASPALSLSLAGIFRDAGATAAAATASASMEVEEGDEGSGGGGGSGSKKDDTVEISSENSGPARSRSEDDLLDHDDDEDDADKSKKKKRKKYHRHTADQIREMEALFKESPHPDEKQRQQLSKQLGLAPRQVKFWFQNRRTQIKAIQERHENSLLKQELEKLRDENKAMRETINKACCLNCGMATTAKDGSITAEEQQLRIENAKLKAEVEKLRTVIGKYPPGASTTGSCSSGNDQENRSSLDFYTGIFGLEKSRIMEIVNQAMEELQKMATAGEPLWVRSVETGREILNYDEYVKEFSVESSSNGRPKRSIEASRETGVVFLDLPRLVQSFMDANQWKEMFPCIISKAATVDVICHGEAPNKNGAVQLMFAELQMLTPLVPTREVYFVRYCKQLSAEQWAIVDVSIDKVEENIDASLVKCRKRPSGCIIQDTTNGHCKVIWVEHXECQKNTVHTLYRTIVRSGLAFGARHWMATLQHQCEGLFFFMATNVPTKDSTGVATLAGRKSILKLAQRMTWSFCHSIGASSYHTWNKVSTKTGEDVRVSSRKNLNDPGEPHGVIVCAVSSVCLPVSPTLLFDFLRDESRRSEWDIMSNGGPVQSIANLAKGKDRGNAVTIQAMKSKENSMWILQDSCTNAFESMVVFAHVDVTGIQSVITGCDSSNMAILPSGFSILPDGLESRPLVISSRHEKSNDTEGGSLLTVAFQILTNSSPTAKLTMESVESVNTIVSCTLRNIKTSLQCEDG
Protein: Phospholipid scramblase (G3MU68)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MQQPVINQQPGYNPQGMNPVQQFEMHQQQHQQAITTQPGVFVQPAPGSVWMPMPPAIQGVPTGLEYLTYLDTIMVHQIKELIEIVTDWETKNKYVLKNANGEQCYYAFEESGCCERQCCGPQRGFVMHIVDNFKREVLTIKREFKCCGGGCCGCLACIGCCQQECIIETPSMGVLGIIRQRCGCMSSNYDIMDGDGNVIFQIDGPCCCMLCGCQDKEFPIKTANNGTVVGAITKKWGGCFREAFTDADTFAVNFPGDLDVKLKGVLIGATFLIDFMEFEQQSQNRNNGGL
Protein: At2g04690/F28I8.27 (Pyridoxamine 5'-phosphate oxidase family protein) (Q8RY62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MELQVLVLRPIFFFFFFVFLTILQQSSSARVLTITKPDRHDYAASARWLVSQNSWGVLSTLSVDHKGAPFGNVVSFSDGLPEKGNGIPYFYLTTLDPTARNALKDQRASLAISESPLGTCTRDPMNPTCSKLTLTGKLLILEGGSEEAEVAKKALFTKHPEMMDWPKDHDFRFFKLEIIDIFLINWYGGAKPITVDEYLHAKSIKLASFL
Protein: Uncharacterized protein (Q581U0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MTVARRTFNFSAEPSQGISKVVWAGRTTIAVMSSVGEVVCLRSGLCEPSNAQNDSENDDGGDGTCEGDSSVLLRIPQHAIDVCALTVNGYAVIVTTDHIRTESYAFAISGGAAAASHQHRELSIGAFQLISGLSDCHGCPAVLLGCTLGSVVLFEWSSVKEKPIAIRSLLMGPTTRYMAISAGVQYVSVATSGEEVERVVTFCALGNTGAEDQAERGALSLKMADGTPLCVMETVSDSTASHYSSVLPSWNDVCRLDSGRPQSVSSLLLVTQPQLSPTAAVPQILVVSVAQDKLHVLRNTSCTDVPAGKRKGSAEALRPETTIDAQIFLATSLECKNALSMFRGDATMVATIRRPRNTTPGKLGGELCLFDSERAIVFGLCENCEVEPRASVGVEHESSLLAGLVWPFDTSDALLLLSGKLLDGCHGSNDVSNDARPKGETKKVTVRTIGDLTLVSEIPQPWRRSGAAGLDEERLTEVVRAVVRQENEKMMQRLEKRLEAIERTLSLLSSQRGRE
Protein: ORF24 (Q4JQV1)
Organism: Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
Subcellular location: Host nucleus inner membrane {ECO:0000256|ARBA:ARBA00043948}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00043948}.
Interaction partners:
Sequence:
MSRRTYVRSERRRGCGDNLLQRIRLVVPSALQCCDGDLPIFDPQRPPARCVFQFNGEDNVSEAFPVEYIMRLMANWAQVDCDPYIKIQNTGVSVLFQGFFFRPTNAPVAEVSIDSNNVILSSTLSTGINLSALESIKRGGGIDRRPLQALMWVNCFVRMPYVQLSFRFMGPEDPSRTIKLMARATDAYMYKETGNNLDEYIRWRPSFRSPPENGSPNTSVQMQSDIKPALPDTQTTRVWKLALPVANVTYALFVVIVLVVVLGAVLFWK
Protein: PI31_Prot_N domain-containing protein (Q19257)
Organism: Caenorhabditis elegans
Interaction partners:
- Ribosomal protein L13
- CP-type G domain-containing protein
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein mL43
- TrmE-type G domain-containing protein
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL24m
Sequence:
MDNFRSEILKETRELMLNEQQHEESMKSWNGPETKGFELKFGGTKRGVPQNSGVVGQVFISEDGGFEAIITGYVIKNSLRSIAASFTVTPSSSLKSDLSEGLHPLVLAIGSALTLNHILMLGSLRDKILKNLTPKSVAKLILSNKKSQQILTSDAVDNTFWKKRLNNDFGNETVQNTITTGRKFYGMYCQKANESRTTARRNEPVRNENPLMIGGPRHPPRHPVHDPYGNRFPDPDTEYYNPLGGFLPPGVPRAGNPNIPDLFRGPDHPDLNPLGPLGQPRGGGSHGRPFMRDPNGRFGGNGGGGGFDGYI
Protein: Lysosomal acid phosphatase (LAP) (EC 3.1.3.2) (P20611)
Organism: Rattus norvegicus (Rat)
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:P11117}; Single-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000250|UniProtKB:P11117}. Lysosome lumen {ECO:0000250|UniProtKB:P11117}. Note=The soluble form arises by proteolytic processing of the membrane-bound form. {ECO:0000250|UniProtKB:P11117}.
Interaction partners:
- Tartrate-resistant acid phosphatase type 5
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Biliverdin reductase B
- Riboflavin kinase.
- FAD synthase
Sequence:
MAGRQSGWSQAALLQFLLGMCLMVMPPIQARSLRFVTLLYRHGDRSPVKAYPKDPYQEEKWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNASYHRQEVYVRSTDFDRTLMSAEANLAGLFPPTEVQHFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNMSIQNAQFLDMVANETGLMNLTLETIWNVYDTLFCEQTHGLLLPPWASPQTVQALSQLKDFSFLFLFGIHDQVQKARLQGGVLLAQILKNLTLMATTSQFPKLLVYSAHDTTLVALQMALNVYNGKQAPYASCHIFELYQEDNGNFSVEMYFRNDSKKAPWPLTLPGCPHRCPLQDFLRLTEPVIPKDWQKECQLASDTADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYHHVADREDHA
Protein: Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (F8VPD4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYGIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF
Protein: Inner membrane protein YgbE (P46141)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Adenylyl-sulfate kinase
- Sulfate adenylyltransferase subunit 1
- Sulfate adenylyltransferase subunit 2
Sequence:
MRNSHNITLTNNDSLTEDEETTWSLPGAVVGFISWLFALAMPMLIYGSNTLFFFIYTWPFFLALMPVAVVVGIALHSLMDGKLRYSIVFTLVTVGIMFGALFMWLLG
Protein: Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG4 (EC 3.2.2.n1) (Protein LONELY GUY 4) (Q9LFH3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19837870}. Nucleus {ECO:0000269|PubMed:19837870}.
Interaction partners:
- Transcription factor LHW
- Transcription factor AIG1
- Pseudo histidine-containing phosphotransfer protein 6
- Adenylate isopentenyltransferase 7, mitochondrial
- Adenylate isopentenyltransferase 3, chloroplastic
- tRNA dimethylallyltransferase 2
- Histidine kinase 4
- Auxin response factor 5
- Dof zinc finger protein DOF2.1
- Cytokinin dehydrogenase 3
Sequence:
MEVNNETMQKSKFGRICVFCGSSQGKKSSYQDAAVDLGNELVLRNIDLVYGGGSIGLMGLVSQAVHDGGRHVIGVIPKTLMPRELTGETVGEVRAVADMHQRKAEMARHSDAFIALPGGYGTLEELLEVITWAQLGIHDKPVGLLNVDGYYNSLLSFIDKAVEEGFISTNARQIIISAPTAKELVKKLEEYSPCHESVATKLCWEIERIDYSSED
Protein: Large ribosomal subunit protein uL22c (50S ribosomal protein L22, chloroplastic) (P56795)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein binds specifically to 23S rRNA.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS3c
- Large ribosomal subunit protein uL14c
- Large ribosomal subunit protein uL16c
- Small ribosomal subunit protein uS8c
- Large ribosomal subunit protein uL24c
- Small ribosomal subunit protein uS11c
- At1g43860
- Small ribosomal subunit protein uS14c
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein bL17c
Sequence:
MIKKRKKKSYTEVYALGQYISMSAHKARRVIDQIRGRSYEEALMILELMPYRGCYPIFKLVYSAAANASHNKGFKETNLVISKAEVNQGNTVKKLKPRARGRSYPIKRSTCHITIVLEDISFYQQYEEYLMYLKKPGCSNENRNLTCYDTYSSGGLWDKK
Protein: Pyridine nucleotide-disulfide oxidoreductase (Q72BM2)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- glutamate synthase
- Oxidoreductase, NAD-binding, putative
- Glutamine--fructose-6-phosphate aminotransferase
- Glutamate synthase, small subunit
- Glutamine synthetase, type I
- L-glutamate gamma-semialdehyde dehydrogenase
- Carbamoyl phosphate synthase large chain
- Glutamine synthetase, type III
- Amidophosphoribosyltransferase
- Pyridine nucleotide-disulfide oxidoreductase
Sequence:
MRAEPLPPNGRKVAIIGAGPSGLAATGYLACMGYQVEVYDKLPGAGGLMVFGIPGHRIPADRIQRGVHILERQYGTIFHTRTKICCSAPLHEEEGDHFSCDIRGLGELVEGYDAVMICTGSWKSRKLGIPGEALPGVYSGLEFLFPIRAVRYATTNVSLPDVAGRIVAVVGAGHSAVDVVHSAHALGAEKVYMVYRRTRREAPCGSFEIDRIEEAGGTWLERCTPTGIVGDGKVEGLELRDSETGETSVLPVDVVVTAIGEIPTPPFQKELGLENVRKGEVRWLHMTSIENVFVAGDVLTGPSKIGKAVYSGLRAARSLANWLDLRAQHRESEYNYDADVIHR
Protein: Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (O08561)
Organism: Rattus norvegicus (Rat)
Function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:11526106, ECO:0000269|PubMed:19458041, ECO:0000269|PubMed:8973579}. Endomembrane system {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9UBF8}. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3, GGA2 is also involved in the recruitment. {ECO:0000250|UniProtKB:Q9UBF8}.
Interaction partners:
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphatidylinositol 4-kinase type 2-alpha
- Phosphatidylinositol 4-kinase alpha
- Phosphatidylinositol 4-kinase type 2-beta
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- Phosphatidylinositol-3-phosphatase SAC1
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Ras-related protein Rab-11A
Sequence:
MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
Protein: cyclin-dependent kinase (EC 2.7.11.22) (Q5BFI1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Cyclin dependent kinase inhibitor Pho81, putative
- Nucleoporin NSP1
- Protein kinase domain-containing protein
- Cell division control protein
- Cyclin-dependent kinases regulatory subunit
- Glycerophosphocholine phosphodiesterase Gde1, putative
- RNA polymerase II holoenzyme cyclin-like subunit
- Serine/threonine protein kinase
- Origin recognition complex subunit 2
- G2/mitotic-specific cyclin-B
Sequence:
MEWKKTLSFTDRLRTIQSLTTAYQQASCSAAFAEAQSQARKIESEAYEQAGSKEEYDQVCQQALDAAEVTVSKTFKSDLDDDTNVANQGNGEQIGPYQNCIHVFDGLHSTIYKSSSESGALVALKITTPHLLEPPHDAHREAQLLREAANEHIIPLLDTLKLDGGRFGLVFPYKKHDLETLFRRDVLTAAQTKSVLRDMFSAIASIHSLGIIHRDIKPSNILLDSPSGPAYLADFGIAWREGSIEAEPADKKITDVGTTCYRPPEVLFGHKGYNTALDLWAAGCVVAEAITVGHKQLFDAGPVGSDLSLIQSIFTTLGTPDEQTWPESKKLPDWGKIEFYKYPAKPWDDILQGSSSNGRDLVSRLVSYESGQRLSAAEALQHPYFSSSKKSTTAV
Protein: Teashirt homolog 3 (Zinc finger protein 537) (Q8CGV9)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with APBB1 in the nucleus. Colocalizes with APBB1 in axonal growth cone (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MPRRKQQAPRRAAAYVSDELKAAALVEDDVEPEEQAADGEPSAKYMCPEKELSKACPSYQNSPAAEFSSHEMDSESHISETSDRMADFESSSIKNEEETKEVQVPLEDTTVSDSLEQMKAVYNNFLSNSYWSNLNLNLHQPSSENNGGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQNRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPAARKKPSLELELPSSPDSTGGTPKATLSDASDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMKKGKPIMETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASVSPKLAVEIKKEVDKEKAVPDEKPKEREKPSEEEEKYDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNSEIVSPTKTQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKVEEKMKEPEGKLSPPKRATPSPCSSEQSEPIKMEASSDGSFKSQENSPSPPRDACKEASPSAEPVENGKELVKPLSGGLSGSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPPLQAKKAEHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSGLLSPTSTSPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNPQHLLILQAQFAASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINNQIAQTKSPSEKLVTSSPEEDLGTTYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLFVSELEKQ