wanglab/gogpt-training-data huggingface dataset:
Protein: Mitochondrial peculiar membrane protein 1 (P40364)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:11791739, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:22984289}; Peripheral membrane protein {ECO:0000269|PubMed:11791739, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:22984289}; Intermembrane side {ECO:0000269|PubMed:11791739, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:22984289}.
Interaction partners:
- mRNA-binding protein PUF3
- MIOREX complex component 9
- Glutaredoxin-like protein YDR286C
Sequence:
MGFYEGDDNDANTKAFNDKYIKDQKFATAPFWNLFPKLRDIDEYDNPLLPLPFNFNFRDLGDSALAMASGIPTVKQFDKCEELKGQSAWTTQGIWKCLVPSKAIPPLPQLDFLLPLEEIKSDKSHSHGLFFNDFNLFLKWRSHMNRLQKQRIKTRSTAVEPLARTPEDLMLNWDDLHLGNDAEYASADGSKKIVGRAQSISTTKDSNDAKPSTVKTEKIYFDDGTVDITTTTTSKGSSPQVKHKVVSVDEDN
Protein: Pre-mRNA processing factor 16, isoform B (EC 3.6.4.13) (Q9VY50)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKESGRSGREKKKQAAEHLKEMEEQMLKAQHEMEERKQQAAEREEQLATKQEIATPGNATPRRTPARIGL
Protein: DNA-directed RNA polymerase subunit beta (EC 2.7.7.6) (Q387I8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA-dependent RNA polymerases, putative
- Plastid-encoded RNA polymerase subunit alpha
- DNA-directed RNA polymerase I subunit RPA1
- Nitroreductase, putative
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase subunit, putative
- Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II, putative
- DNA-directed RNA polymerases II subunit, putative
Sequence:
MSTKNSVVGSASGSHASTAGETVTSTRSGTSSRHSRQRRQQYDYVKNPSEPMTAMERLKLVRCSIARLRYLGERHRHTSKLDTTGGDRLLSFFEGLRKRVLKLEYNPRVVAKSKVGAPKHLDYIRGHANALLGEASTIISECEQAMDRSEAVYEGLAYHQLQDTHRELENLVGLLSGAPSDMESAGSLKLLADLVSPHVAEFDAFAEQRVPEFLQELKNEGFLFSSVINDSQQPANAIGLLSVFIVDVAIGVRPGRSARLVIQHALHNLARLKSRVDKADLTLGAEEDSSNNEHHRMQSLEFEVIRGRLREAKEELERIRDKWDHDEGDIFSRAGTGVQGLQSIIDAKRVKESTVIEEAQAIHDRTVYACLPFASPQYCRIRSETYSQPCHVRVGFKFVAKGDGSVSRTKTQLIYNLMPEFLILMRQQGIAPSDQERFATLAPSKYELWLSLGELPEMVLGARCALRGVNQRLDHFRALEEQKEVGGYFVLRGGERILRNLILQRCNVPLNIERERFATVDSFFSPRAVIIRCKRPSGLTVQNYFYYATKGEVIFTFARRVVWNIPALLVLSALNTRHRTSLDIYKLLTIGLTNGRSPHAARVEALLQHHSQMPYSTLDNFLDYLAVVGLMYRRYHESSFIFRFLPQYHTSFATQHDAWYGLFMLRRHMLPHLNTAEATPDLPPTATSREIREWLSTGLQEELAAKFDALIGILRQLLVFNDGATGNQGNDVLAYQEVFTVSQVLIGAFEVSLMKTMGAVTFRMAGQLSPEIFQATMCLAETPIREAANTLEKLNQLLEYSCRNNGPDPLITLNRLLLTGNFALDREEDFYSPQTAGWAVMTEHLNFYRSFEQLMCVHRGKSIAEMRSSDVRRYPCEAYGFICMVHSPDGEDCGVLNHLSISTVLSASPRVGSSQYKILLAFIEEELKNVRNTTSLISCVDQLVGTVPVWLEGRLLGYLSPNEALSASKALTQKKALRSRGVVGVTGIVRRDSISSLNTMEVVYIPPGSKDPMGLYIFYQYGRLMRPVLQIESPSRGGDLPFPVVYLGTWEQSWRDIAAVPSDLFDGFDQLRRKYEFMEQNGFNILSFTSSTIPFFEHNCSPRNLFQCGLSKQTAGTQLQTQAWRRDAKLFRMYYPQRYISRTLPMDYFGLDDVSLGVNAVVAILAYTGYDLDDAMILNSTAKQFGMLNAGVTVAKIVKASGKGDSNDVFVFHNCLPDGQPFTPELDRHGLPKKRAVPNATAYFSFDTDHKYPSLRDSSAVYCCAKRFEYIDPLTNEKTYEYTRHQITKWRHFDKGEDAWVHSVIPLTYDGPDPTSVLVLFRIPRPPVIGDKFSSRHGQKGTLPLDIRSHDLPFSTRDGITPDIIINPHAFPSRMTVGMVLEMMGAKLGCIQGRLCDHSAWSVIDEQPRSAKTIGDALEALGYNRYGREKLIDGITGEEIEAEVLVGISGYQRLRHMVSDKWQARARTDSHTHRAVTKTGQPVKGRKRHGGVRVGEMERDALLSHGVAEVVIDRLLHVSDKTKAFICVECGSMLSIYERHATEYSTWKTCKFCSAGLHETDDTIAFVEIPQVLRLWATELTSVGIRVVLKTSETSL
Protein: SAGA-associated factor 11 (11 kDa SAGA-associated factor) (Q03067)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SGF11 is involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex with SUS1, SGF73 and UBP8 required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. It is required to recruit UBP8 and SUS1 into the SAGA complex.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03047, ECO:0000269|PubMed:14562095}.
Interaction partners:
- SAGA complex subunit SGF29
- SAGA complex subunit SPT8
- SAGA complex subunit SUS1
- SAGA complex/transcription factor TFIID complex subunit TAF6
- SAGA complex/transcription factor TFIID complex subunit TAF5
- SAGA complex subunit SPT7
- SAGA complex subunit ADA2
- Ubiquitin carboxyl-terminal hydrolase 8
- SAGA complex/transcription factor TFIID complex subunit TAF9
- SAGA complex/transcription factor TFIID complex subunit TAF10
Sequence:
MTEETITIDSISNGILNNLLTTLIQDIVARETTQQQLLKTRYPDLRSYYFDPNGSLDINGLQKQQESSQYIHCENCGRDVSANRLAAHLQRCLSRGARR
Protein: Lysophosphatidylinositol acyltransferase 10 (ACL-10) (sn-2 acyl LPIAT) (EC 2.3.1.-) (2-acylglycerol 3-phosphate O-acyltransferase 10) (AGPAT 10) (PlsC domain-containing protein) (Q20800)
Organism: Caenorhabditis elegans
Function: Acyltransferase required for the fatty acid remodeling of phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI). Mediates the conversion of lysophosphatidylinositol (2-acylglycerophosphatidylinositol or LPI) into PI (LPIAT activity). Has preference for saturated and mono-unsaturated fatty acids as acyl donors and sn-2-acyl lysoPI (2-acyl-sn-glycero-3-phospho-D-myo-inositol) as acyl acceptor. Contributes to the asymmetric cell division of epithelial cells. Asymmetric cell division is the fundamental mechanism by which multicellular organisms generate cell diversity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20668164}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Tafazzin family protein
- Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2
- Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1
- Probable glycerol-3-phosphate acyltransferase, mitochondrial
- Phosphatidate cytidylyltransferase
- Cardiolipin synthase
- Lysophospholipid acyltransferase
- Membrane Bound O-Acyl transferase, MBOAT
- Phospholipid/glycerol acyltransferase domain-containing protein
- Phospholipid/glycerol acyltransferase domain-containing protein
Sequence:
MRIPCLLRPLLGWFFGLCILFSALFGNYIITLFLGLPILGRHKQWRNLMDRAISYWMTIPMGLLEFLMGVRIRVSGDEIEFGSPAMIVMNHRTRLDWMYMWCALYQINPWLITSNKISLKAQLKKLPGAGFGMAAAQFVFLERNAEVDKRSFDDAIDYFKNIDKKYQILLFPEGTDKSEWTTLKSREFAKKNGLRHLDYVLYPRTTGFLHLLNKMREQEYVEYIYDITIAYPYNIVQSEIDLVLKGASPREVHFHIRKIPISQVPLNEQDASRWLTDRWTIKEQLLHDFYSEEQPINRQFPVERGDGVWRSWKEPRRHFYVKLTSLMFWTLVISFCSYHIFFVRTLQLGFLYFFVISFYLSWRYGGIDKYIIFKWQESRKSLQKSPSSSSI
Protein: Serine/threonine-protein kinase PTK1/STK1 (EC 2.7.11.1) (P36002)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential determinant for low-affinity spermidine transport.
Interaction partners:
- Probable pseudouridine-5'-phosphatase YKL033W-A
- Suppressor of lethality of KEX2 GAS1 double null mutant protein 1
- Serine/threonine-protein kinase ATG1
- Dilute domain-containing protein YPR089W
- Uncharacterized protein YJL016W
- Cell wall protein PIR5
- Uncharacterized protein YJL107C
Sequence:
MTVSHNHSTKISQQPISSVSAFKFFGKKLLSSSHGNKLKKKASLPPDFHSTSTNDSESSSPKLPNSLKTSRRANSFAHTTNSKRSLSSASTKILPPAGSSTSISRGNRHSSTSRNLSNSKFSSERLVYNPYGVSTPSTSLSSVSTSMKKDPDLGFYLHDGDSKIRMLPIPIVDPNEYLPDEMKEASIQLSDNFVFDDENKTIGWGGSCEVRKIRSKYRKKDVFALKKLNMIYNETPEKFYKRCSKEFIIAKQLSHHVHITNTFLLVKVPTTVYTTRGWGFVMELGLRDLFAMIQKSGWRSVALAEKFCIFKQVACGVKFCHDQGIAHRDLKPENVLLSPDGVCKLTDFGISDWYHTDPHDLSSPVKKCAGMIGSPPYAPPEVMFYDSKKHYDTELQQPYDPRALDCYGLGIILMTLVNNVIPFLESCSFDTGFRDYCDAYENFIRLHDRAFRNRGNYRPGPGMEYHLARNFKNGHASRVAWRLADPEAATRYTIDDLFEDPWFQGIETCVDANDKYVCKKPIIKTTTYENPRGFHIATDVAATTPTSNPFLKNRVPIRSMVDIAAHPSPTATVLASSPPPPPPATHVPAEALFTLRETPPPQLATLTLSEEPPATPAPSAPSAPSARVRGHSPHRVVHHHLNIVNSLVHSSSAASSQVPAST
Protein: Transporter (Q4FIV5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MNSRKNGAVPGEPVKRDENSRRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFLELSFGQFTSLGCLGVWKVSPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTNLLPWTYCNNPWNTPDCSGVVSTHRANATFANMSAVVSGVTEIVNRTKRTSPSEEYWRNYVLNISDGIGNFGEVRLPILGCLAVSWFVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFIRGITLDGAISGIKYYLTPQWQKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCFRDSIIISVTNCGTSVYAGFVIFSILGFMAHHLGVDVSEVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAVVDEIGTDWIIKNKTYVTLGVAIIGFLLGVPLTTQAGIYWLLLMDNYAASFSLVIISCIMCICIMYVYGHKNYFKDVEMMLGFPPPIFFRICWRYVSPFIITFILIFTVIQYKPITYNDYVYPGWSLVIGFAMALSSVICIPIYALFKIAMSEGSTFLERLKNSVKPDPDWGPALQEHRKGRYATAGPESVEVSPLKEDLKDEGKDKLTEKEKETEKKDEIGLTIPGSNGSTLNPTPSA
Protein: acetyl-CoA carboxylase (EC 6.4.1.2) (O70151)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MVLLLFLTYLVFSCLTISWLKIWGKMTDSRPLSNSKVDASLLPSKEESFASDQSEEHGDCSCPLTTPDQEELASHGGPVDASQQRNSVPTSHQKPPRNPLSSNDTCSSPELQTNGVAAPGSEVPEANGLPFPARPQTQRTGSPTREDKKQAPIKRQLMTSFILGSLDDNSSDEDPSSNSFQTSSRKGSRDSLGTCSQEAALNTADPESHTPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGNRVIETVLIANNGIAAVKWMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYYKMADPVLPVPGGPNNNNYANVELIIDIAKRIPVQAVWAGWGHASENPKLPELLCKHGIAFLGPRVRPMLGLGDRLSSTIVAQTLQIPTLPWSGSGLTVEWTEDSQHQGKCISVTEDVYEQGCVRDVDEGLQAAEKVGFPLMIKASEGGGGKGIRQAESAEDFPCFFRQVQSEIPGSPIFLMKLAQNARHLEVQVLADQYGNAVSLFGRDCSIQRRHQKIIEEAPANIAAPAVFEFMEQCAVLLAKTVVYVSAGTVGYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPVSFETPLSPPIARGHVIAARITSENPDEAFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFPISQFGHCFSWGENQEEAISNMVVALKELSIRGDFRTTVEYLVNLLETESLQNNDIDTGWLDHLIAQRVQAEKPDIMLGVVFGALNVADAMFRTCITEFLHSLERGQVLPADSLLNIVDVELIYGGIKYVLKVARQSLTMFVLIMNGCHIEIDAHRPNDGGLLLSYNGSSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLMQYTVEDGQHVEVGSSYAEMEVMKMIMTLNVQESGRVNYIKRPGAVLEAGCVVAKLELDDPSKVHAAQPFTGELPAQQTLPILGERLHQVFHSVLENLTNVMNGYCLPEPFFSMKLKDWVEKPMMTLRHPSLPLLELQEIMTSVADRIPVPVEKAVRRVFAQDASNITSVLCQFPSQQIATILDCHAATLQRKVDREAFFMNTQSIVQLIQRYRSGTRGIMKAVVLDLLRRYLNVEHHFQQAHYDKCVINLREQFKADMTRVLDCIFSHSQVAKKNQLVTMLIDELCGPDPTLSEELTSILKELTQLSRSEHCKVALRARQVLIASHLPSYELRHNQVESSSCQPLTCNGHQFCPENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRELPDGTCVVEFQFMLPSSHPNRMAMPINVSDPDLLRHSKELFMDSGFSPLCHQRMGAMVAFRRFEEFTRNFDEVISCFANVPTDTPLFSKACTSLYSEEDSKSLQEEPIHILNVAIQCADHMEDERLVPVFRAFVQSKKHILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPGLAFQLELSRMRNFDLTAVPCANHKMHLYLGAAKVKEGLEVTDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVAHVIMDPLKIEESVRAMVMRYGSRLWKLRVLQAQVKINIRQTTSDCAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSFGNKQGSLHGMLINTPYVTKDLLQAKRFQAQSLGTTYVYDFPEMFRQALFKLWGSPEKYGPDILTYTELVLDSQGQLVEMNRLPGCNEVGMVVFKMRFKTPEYPEGRDTIVIGNDITFQIGSFGIGEDFLYLRASEMARTEGIPQIYLAANSGAVLGLSEEIKQIFQVAWVDPEDPYKGFRYLYLYLTPQDYTQISSQNSVHCKHIEDEGESGIIVDVIGKDSSLGVENLRGSGMIAGEASLAYEKNVTISMVDCRAIGIGAYLVRLGQRVIQVENSHIILTGAGALNKVLGREVYTSNNQLGGVQIMHTNGVSHVTVPDDFEGVCTILEWLSYIPKDNQSPVPIITPSDPIDREIEFTPTKAPYDPRWLLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWDQTVVTGRARLGGIPVGVIAVETRSVEVAVPAHPANLDSEAKIIQQAGQVWFPDSAFKTAQVIRDFNQEHLLLMIFANWRGFSGGMKDMSEQMLKFGAYIVDSLRLSKQPVLIYIPPGAELRGGSWVVLDSSINPLCIEMYADKESRGGVLEPEGTVEIKFRKKDLVKTIRRIDPVCKKLLEPAGDTQLPDKDRKELESQLKAREDLLLPIYHQVAVQFADLHDTPGHMLKKGIISDVLEWKTTRTYFYWRLRRLLLEAQVKQEILRASPELSHEHTQSMLRRWFVETEGAVKAYLWDSNQVVVQWLEQHWSARDNLRSTIRENLNYLKRDSVLKTIQSLVQEHPEATMGLCGYLSQHLTPAEQMQVVQLLSTTESPASH
Protein: Paired mesoderm homeobox protein 2A (Aristaless homeobox protein homolog) (PHOX2A homeodomain protein) (Paired-like homeobox 2A) (Q62066)
Organism: Mus musculus (Mouse)
Function: May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Dopamine beta-hydroxylase
- Insulin gene enhancer protein ISL-1
Sequence:
MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGATGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPPAPSLASPRLSPSPLPAALGSGPGPQPLKGALWAGVAGGGGGGPGTGAAELLKAWQPAEPGPGPFSGVLSSFHRKPGPALKTNLF
Protein: Cdc20 protein (Cell division cycle 20 S homeolog) (Q8AVG7)
Organism: Xenopus laevis (African clawed frog)
Interaction partners:
- Uncharacterized protein.
- Uncharacterized protein.
- Securin
- Cdc16-prov protein
- Mitotic checkpoint protein BUB3
- Uncharacterized protein.
- Cell division cycle protein 27 homolog
- Serine/threonine-protein kinase PLK.
- Serine/threonine-protein kinase PLK
- F-box domain-containing protein.
Sequence:
MAQFAFETDINSILKLDTPITNAPLARWQRKAKEGNCSLNTSANTSTMSPMKTSNRSHSSSKTPSKTPGKSGQKMQGTPSRAGGDRFIPNRSAMQMDVASFLLSKENEPTDTSPTKKEQQKAWAMNLNGFDMEEAKILRLGGRPQNAPEGYQNNLKVLYSQKNTPGSSKKTGRYIPSMPDRVLDAPDIRNDYYLNLIDWSSQNALAVALNDSVYLWNYATGDIILLLQMENSEEYISSVSWIKEGHFLAVGTSNSEVQLWDVQQQKRLRNMISHSSRVGALSWNNHILSSGSRTGHIHHHDVRVAQHHVSTLTGHTQEVCGLKWSPDGRYLASGANDNLVNVWPCVQGDSGEFSPVQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGTCLNSVDTHSQVCSILWSANYKELISGHGFAQNQLVLWKYPTMTRVSELKGHTARVLNLAMSPDGCTVASAAADETLRLWKCFEVDPVTKKEKEKSRSSKSIIHQSIR
Protein: GM03282p (Q95SC8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}.
Interaction partners:
Sequence:
MSGNQQQQQQQQKSLTNNAAAAATNEATTLGHNLIKINSVDKIVGKSQAATQAINKLQQQQQHQQQQIHQRRSLLPATGGATNPHQPHSSQQQSGTPTPTAQSAAQKQQQQQQQSHQLQTVATIHQPHSTQQQALTSRLPIQQQSAKELPNLAGQQRRSFHYQLQNQQQSLRSPQLKAPAPAHSIPPRYQPPPQPATGILKPHLPLKYPPDIPQLSSIYIPDSIKQQQQQQQQQQSRYLPAHQPGAKDMLKFVRKPDQEHPSPNASVTSSGTGIPTANGGGRLTAEQNRQLQSLVNELRALKEQNQRLLDDNQELRDLCCFLDDDRQKGRKLAREWQRFGRYTASVMRQEVAAYQNKLRQLDDKQQELITDNLELKELCLYLDEERAHVAANALCAGCGAATRNALRDDGDGSSSSTNADETITALRNYAEQRQLPQDLRHAHTLNDQTLQYVRSLERRIQQLEEERTTPTAHLQQPTTPTPQATPTPTATSAATPAKSAASPHQQQQQQQQQQHQQQQQDIVAAAAAAAAAIQLPEPIAGRPEAVVRALQVLEVREQLERDRLGNLAGSALDQMDDGEKALVREMCNVVWRKLEGSPHGPAALEPL
Protein: Condensin complex subunit 2 (Q57ZI0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Structural maintenance of chromosomes protein
- Nuclear condensin complex subunit 3 C-terminal domain-containing protein
- Structural maintenance of chromosomes protein
- Condensin subunit 1, putative
- Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein
Sequence:
MQHTEAQSQQILPRSGRGGECFADTHTQVDDGASVVFPAAGGLCSQSQTPQAPRRRPRVITAQDLDEALLQAIEGKITRKNAWVSKDASNLLDGITQTVESTLDSNSTVDEYTSFAKVATVVEGCSKVWTSRVDSTYQRSNQMVRRLLRNEDEGHGSDEENKEEGDGEGGAPSTSAAAERRRRAAQRKGQTVRTIAFDLSEINLDRKARLALVRTGVSAQFRAITEKFDQGNAQGLLVHNTPIGGAGNLILDVDYVREPDGDYTADCGRHSGQSDKVKSEPDEGENINTTARGFADGGIEDGVDEGLRITLDLPPFTASHMQSNAEKNSLFVCGGGHLVGDGAGSAVSTNDRSGEGARVSSSSFSTDPNASGRPSLTVPSLLAVPHTVQGNPDVLPDDATRVATNEQDGNEEHDYQDGGWFDGMDGADADYGLHDGGESIDQDRYTADNGRGEESNPELSPERVALEARRLVSGVTDLNIMDNRLRNKQLALEVDDPSGWVPMAEPVSNPMFGARARKNSTIMMTLRKQHHFLGPSVAQSSISTQSLKRLKREAAVFDLPGELEAVSATASRRSAGTKEKSTKGDDCIHLPPVFALLEDSGVDNSALKQSTSEGKNMSALGKELLLGRDSSAIKPYLQTSVELTKAQEAGLLVRENPVPGVTVPSYLPYPITVPVFFQPFSTPLSQWNLLRKSATGSTIHHYNNATSYGYADEDADGNGAGDMPAEFFHGGVDSDNDYGDVGTYDGFNDSTRDDTLDNPLKLAQAQIFASLDQADLIRSSTALTTLSGNSARPSSMNVSDVADIDPDTVVKVLHAPEAMLPTQVDVVLLRKIMWASLTGAAGCEVTEQQESQRVSRRKRGRVAGTEGPTQKEDNQGSDDGVKKVRFSEVVLQLLPQVSTVSATGALSPAFFFFSLLFLANEHGLLIESVPTLDDLVVHVPPQRGDASETMVNAD
Protein: ATP-dependent RNA helicase glh-2 (EC 3.6.4.13) (Germline helicase 2) (Q966L9)
Organism: Caenorhabditis elegans
Function: Probable ATP-binding RNA helicase.
Interaction partners:
- Guanyl-specific ribonuclease pgl-1
- Guanyl-specific ribonuclease pgl-3
- BTB domain-containing protein
- P-granule-associated protein deps-1
- ATP-dependent RNA helicase cgh-1
Sequence:
MSDDWDNNTAAAKTISFGSNPSGFGGGSGFGSGNTGGFGSGNAGGTGFGSSNNGGSGFGGNNNVGPRFGNGNAGGTGFGSGNAGGTGFGSGNAGGTGFGSGNAGGTGFGSGNAGGTGFGGGNAGGTGFGSGNAGGTGLGSGNAGGTGFGSGNAGGTGFGSGNAGGTGFGSGKAGGTGFGSGKAGGTGFGGNSNSGSGFGSGLTNGFGSGNNHESGFGGGKSGGFGGGNSGGSGFGSGGNSNGFGSGGGGQDRGERNNNCFNCQQPGHRSNDCPEPKKEREPRVCYNCQQPGHNSRDCPEERKPREGRNGFTGGSSGFGGGNGGGTGFDSGLTNGFGSGNNGESGFGSGGFGGNSNGFGSGGGGQDRGERNNNCFNCQQPGHRSNDCPEPKKEREPRVCYNCQQPGHNSRDCPEERKPREGRNGFTSGFGGGNDGGFGGGNAEGFGNNEERGPMKCFNCKGEGHRSAECPEPPRGCFNCGEQGHRSNECPNPAKPREGAEGEGPKATYVPVEDNMEEVFNMQKISEGLMFNKFFDAEVKITSDKKPVGVKTCKTFSEANLGETMKKNVAHAGYTKTTPIQQYTLPLIHQGHDIMACAQTGSGKTAAFLLPIMARLIDENDLNTAGEGGCYPRCIILTPTRELTDQIYNEGRKFAYQTMMEIRPVYGGLAVGYNKGQIEKGATIIVGTVGRIKHFCEEGTIKLDKCRFFVLDEADRMIDAMGFGTDIDTIVNYESMPKKENRQTLMFSATFPDSVQEAARNHLKEGYIMLAIDKIGAANKCVLQEFEKCDRSEKKDKLLEILGIDIDSYTTEKNSEVYTKKTIVFVSQRAMADTLASILSSAQVPAITIHGAREQRERSEALRQFRNGSKPVLIATAVAERGLDIKGVDHVINYDMPDNIDDYIHRIGRTGRVGNAGRATSFISEDCNLLSELVRVLSDADQLVPEWMQGASGGNFGASFGFESSVPTQKQDEDCW
Protein: 4,5-DOPA dioxygenase extradiol-like protein (EC 1.13.-.-) (O74741)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in the metabolism of aromatic compounds.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized dipeptidase C965.12
- Uncharacterized dipeptidase C3A11.10c
- Probable NADH-ubiquinone oxidoreductase C947.15c, mitochondrial
Sequence:
MASSRLLDWMSRMRSVPQLERLIPALYLAHGSPFLMLPQSSDDEVFSNDSKLGGLHYQFLEQLGPFLLEKFRPKGIIVFSAHYESRGSVEVYSRDDENPLFYDYYGFPDYLYQIKFHSKGSKRIADQIISALKEYQIPAKTVSGDRGLDHGVFVPFKIMFPDGLNIPLIEVSMHTLDPMQLYKVGQALQSLRKEYLIVSGGLNIHTFEDLSAFNEDTAADGYKEFQLDILKAIETDKQNDRLNKLLGLQLHPYFRKAHPREEHFVPLYVAAGLGSSGKSKVVCDLYGAVSAFFGIDE
Protein: N(6)-adenosine-methyltransferase MT-A70-like protein (EC 2.1.1.348) (Inducer of meiosis 4) (Methyltransferase-like 3) (Q9VCE6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the heterodimer formed with Mettl14, constitutes the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. During oogenesis, required for egg chamber development probably as part of the N/Notch signaling.
Subcellular location: Nucleus {ECO:0000269|PubMed:21873203, ECO:0000269|PubMed:27919077, ECO:0000269|PubMed:27919081, ECO:0000269|PubMed:28675155}.
Interaction partners:
- Pre-mRNA-splicing regulator female-lethal
- N
- Protein virilizer
- Fl
- RNA-binding protein spenito
- E3 ubiquitin-protein ligase Hakai
- YTH domain-containing protein 1
- LD23072p
- YTH domain-containing family protein
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
Sequence:
MADAWDIKSLKTKRNTLREKLEKRKKERIEILSDIQEDLTNPKKELVEADLEVQKEVLQALSSCSLALPIVSTQVVEKIAGSSLEMVNFILGKLANQGAIVIRNVTIGTEAGCEIISVQPKELKEILEDTNDTCQQKEEEAKRKLEVDDVDQPQEKTIKLESTVARKESTSLDAPDDIMMLLSMPSTREKQSKQVGEEILELLTKPTAKERSVAEKFKSHGGAQVMEFCSHGTKVECLKAQQATAEMAAKKKQERRDEKELRPDVDAGENVTGKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTCSSETTDKCTKLHFKKIIQAHTDESLGDCSFLNTCFHMATCKYVHYEVDTLPHINTNKPTDVKTKLSLKRSVDSSCTLYPPQWIQCDLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWVTGRAMELGRDCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPTNLNRGLDCDVIVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELITQFQKRYPDGNCMSPASANAASINGIQK
Protein: Synaptonemal complex protein 1 (SCP-1) (Q62209)
Organism: Mus musculus (Mouse)
Function: Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility.
Subcellular location: Nucleus {ECO:0000269|PubMed:16717126}. Chromosome {ECO:0000269|PubMed:15937223, ECO:0000269|PubMed:16717126, ECO:0000269|PubMed:16968740, ECO:0000269|PubMed:22761579, ECO:0000269|PubMed:30272023, ECO:0000269|PubMed:30746471, ECO:0000269|PubMed:30949703}. Chromosome, centromere {ECO:0000269|PubMed:22761579}. Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (PubMed:22761579). {ECO:0000250|UniProtKB:Q03410, ECO:0000269|PubMed:22761579}.
Interaction partners:
- Synaptonemal complex central element protein 1
- Synaptonemal complex central element protein 2
- Testis-expressed protein 12
- Synaptonemal complex protein 3
- Synaptonemal complex central element protein 3
- Synaptonemal complex protein 2
- Meiotic recombination protein REC8 homolog
- HORMA domain-containing protein 1
- Structural maintenance of chromosomes protein 1B
- Protein SIX6OS1
Sequence:
MEKQKPFTLFVPPRLSSSQVSAVKPQTAGGDSNYFKTANKCTEGDFGVPFTMSSRENIDKDPAFQKLSILPMLEQVANSGSCHYQEGVNDSDFENSEPMSRLYSKLYKEAEKIKKWKVSIESELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATIHWCNLLKETCARSAEKTNKYEYEREETRQVYVDLNSNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYQKEVNNKENQVSELLIQSAEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELSEKKDHLTSELEDIKMSMQRSMSTQKALEEDLQIATKTISQLTEVKEAQMEELNKAKTTHSFVVTELKATTCTLEELLRTEQQRLEKNEDQLKLITVELQKKSNELEEMTKFKNNKEVELEELKNILAEDQKLLDEKKQVEKLAEELQEKEQELTFLLETREKEVHDLQEQVTVTKTSEQHYLKQVEEMKTELEKEKLKNTELTASCDMLLLENKKFVQEASDMALELKKHQEDIINCKKQEERLLKQIENLEEKEMHLRDELESVRKEFIQQGDEVKCKLDKSEENARSIECEVLKKEKQMKILESKCNNLKKQVENKSKNIEELHQENKTLKKKSSAEIKQLNAYEIKVSKLELELESTKQRFEEMTNNYQKEIENKKISEGKLLGEVEKAKATVDEAVKLQKEIDLRCQHKIAEMVALMEKHKHQYDKIVEERDSELGLYKNREQEQSSAKIALETELSNIRNELVSLKKQLEIEKEEKEKLKMAKENTAILKDKKDKKIQASLLESPEATSWKFDSKTTPSQNISRLSSSMDSGKSKDNRDNLRASAKSILPTTVTKEYTVKTPTKKSIYQRENKYIPTGGSNKKRKTAFEFDVNSDSSETADLLSLVSEEDVSNRLYDNNPPDSHLLVKTPKQTPLSLSTPASFMKFGSLKKMREDRWTTIAKIDRKRRLKEAEKLFS
Protein: GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) (Q8IYK8)
Organism: Homo sapiens (Human)
Function: Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9WTY2}.
Interaction partners:
Sequence:
MHTDLDTDMDMDTETTALCPSGSRRASPPGTPTPEADATLLKKSEKLLAELDRSGLPSAPGAPRRRGSMPVPYKHQLRRAQAVDELDWPPQASSSGSSDSLGSGEAAPAQKDGIFKVMLVGESGVGKSTLAGTFGGLQGDSAHEPENPEDTYERRIMVDKEEVTLVVYDIWEQGDAGGWLRDHCLQTGDAFLIVFSVTDRRSFSKVPETLLRLRAGRPHHDLPVILVGNKSDLARSREVSLEEGRHLAGTLSCKHIETSAALHHNTRELFEGAVRQIRLRRGRNHAGGQRPDPGSPEGPAPPARRESLTKKAKRFLANLVPRNAKFFKQRSRSCHDLSVL