wanglab/gogpt-training-data huggingface dataset:
Protein: 3-ketosteroid-9-alpha-monooxygenase, oxygenase component (3-ketosteroid-9-alpha-hydroxylase, oxygenase component) (KSH) (Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase) (EC 1.14.15.30) (Rieske-type oxygenase) (RO) (F1CMY8)
Organism: Rhodococcus rhodochrous
Function: Probably involved in the degradation of cholesterol. In vitro, catalyzes the introduction of a 9alpha-hydroxyl moiety into the ring B of 3-ketosteroid substrates such as 1,4-androstadiene-3,17-dione (ADD), 4-androstene-3,17-dione (AD), 4-androstene-17beta-ol-3-one (testosterone), 4-pregnene-3,20-dione (progesterone), 19-nor-4-androstene-3,17-dione, 1-(5alpha)-androstene-3,17-dione, 5alpha-androstane-3,17-dione, 5beta-androstane-3,17-dione, 5alpha-androstane-17beta-ol-3-one (stanolon), 11beta-hydrocortisone, 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 23,24-bisnorcholesta-4-ene-22-oate, 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4-BNC) and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA). KshA5 has the broadest substrate range without a clear substrate preference and is active with Delta-4, Delta-1,4, 5alpha-H and 5beta-H steroids, as well as with steroids having bulky aliphatic side chains and an isopropionyl side chain at C17.
Interaction partners:
- 3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component
- Unannotated protein.
- Unannotated protein.
- Unannotated protein.
- Unannotated protein.
- Unannotated protein.
- 3-ketosteroid-9-alpha-monooxygenase, oxygenase component
- Unannotated protein.
- Unannotated protein.
- Unannotated protein.
Sequence:
MSIDTARSGSDDDVEIREIQAAAAPTRFARGWHCLGLLRDFQDGKPHSIEAFGTKLVVFADSKGQLNVLDAYCRHMGGDLSRGEVKGDSIACPFHDWRWNGKGKCTDIPYARRVPPIAKTRAWTTLERNGQLYVWNDPQGNPPPEDVTIPEIAGYGTDEWTDWSWKSLRIKGSHCREIVDNVVDMAHFFYIHYSFPRYFKNVFEGHTATQYMHSTGREDVISGTNYDDPNAELRSEATYFGPSYMIDWLESDANGQTIETILINCHYPVSNNEFVLQYGAIVKKLPGVSDEIAAGMAEQFAEGVQLGFEQDVEIWKNKAPIDNPLLSEEDGPVYQLRRWYQQFYVDVEDITEDMTKRFEFEIDTTRAVASWQKEVAENLAKQAEGSTATP
Protein: Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) (Q12959)
Organism: Homo sapiens (Human)
Function: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:11723125, ECO:0000269|PubMed:21849460, ECO:0000269|PubMed:8922391}; Peripheral membrane protein {ECO:0000269|PubMed:8922391}. Basolateral cell membrane {ECO:0000269|PubMed:12807908}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q62696}. Postsynaptic density {ECO:0000250|UniProtKB:Q62696}. Synapse {ECO:0000250|UniProtKB:Q62696}. Cell membrane, sarcolemma {ECO:0000269|PubMed:12445884}. Apical cell membrane {ECO:0000269|PubMed:12445884}. Cell junction {ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:11723125, ECO:0000269|PubMed:7937897}. Cytoplasm {ECO:0000269|PubMed:10859302}. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells (PubMed:12807908). May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity). {ECO:0000250|UniProtKB:Q62696, ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:12807908, ECO:0000269|PubMed:8922391, ECO:0000269|PubMed:9192623}.
Interaction partners:
- Glutamate receptor 1
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Glutamate receptor ionotropic, NMDA 2B
- Disintegrin and metalloproteinase domain-containing protein 10
- Mitogen-activated protein kinase 12
- Peripheral plasma membrane protein CASK
- Glutamate receptor ionotropic, NMDA 2A
- Lethal
- Ubiquitin-protein ligase E3A
- Disks large homolog 3
Sequence:
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL
Protein: G protein-coupled receptor 55 (Q14BW0)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSQPERDNCSFDSVDKLTSTLQLAVHIPTFLLGLVLNLLAIRGFSAFLKKRKLDYIATSIYMINLAVFDLLLVLSLPFKMVLPQVESPSPAFCTLVECLYFISMYGSVFTICFISLDRFLAIQYPILASHLRSPRKTFGICCIIWMLVWIGSIPIYTFHREVERYKCFHNMSDVTWSASVFFPLEIFGFLLPMGIMGFCSYRSIHILLRRPDSTEDWVQQRDTKGWVQKRACIWTIATNLVIFVVSFLPVHLGFFLQYLVRNRFILDCRMKQGISLFLQLSLCFSNINCCLDVFCYYFVIKEFRMRIKAHRPSTIQLVNQDTMVSRG
Protein: Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) (Q9DE32)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU365061}. Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
Interaction partners:
- PUA domain-containing protein.
- Telo_bind domain-containing protein.
- Telomerase Cajal body protein 1
- H/ACA ribonucleoprotein complex subunit 2
- TERF1
- X-ray repair cross-complementing protein 5
- Ku domain-containing protein.
- telomere End-binding protein PTOP isoform X1
- Uncharacterized protein XB5835883.S isoform X1
- Telomerase protein component 1
Sequence:
MPLRTGGATLLSILQRLYGQVLGIVEYTDTLQVPGGIKVPVLLEGDSEKFRSFVAELVVCIPRGTKPLPSPVSFLQLSTQREVVARVIQRICEKKRKNVLAFGYGLVDEKNSLNIRLTPNICNYFPNPTTTTISTSILWETLLTRVGDDVMMYWLEQCSIFVFVPPRCCYQITGQPIYTLPSDDVFLFQSQSFTQSNVLLRYIKRNVFHLRKKYLKPKHSMTSRMLTWRRNKSPSGLLIRSKTSMAVTTEIHSKRKLCSKDICVIPDKKRRDNLDKDDTVDHFDLPMCRSVSYLSNMYPKTNVQVTGLITSGYKKTKTFQCQKPVSCEQKKTTAFYSVAGDCNLSLKDNVNKLITNASVPTAQSRLSFSNIFIDFGRTLYLSISYKKGFSESFILNSLDSTPSGSQKLVETIFLSNFLAEQNFDQPKRDENCRYKLPKRYWKMKPHFQELIQNHKKFPYLVYLNKHCPVRSSMACSEKRSLQKNRIENDGKQLKHFTTKANLLSLLKQHSSIWQVYMFVRECLNNVVPDIMWGSSHNKCRFFRNVKSFLFFSGKFGKISLSELMWSMRVEDCSWIRLQKSDHFVPASEHLLREKILAKFVFWLMDTYVIQLLKSFFYVTETMFQKHRLLFYRKSVWKKLQNIGLRKHLEKVKLRSLSSDELENMQQWKNVPLVSRLRFIPKTNGLRPISKISSTLSSQQSKENQEKKIHHFSSQIRNLFSVLNYEWNRNCSLIGSSVFGMDDIYKKWKKFVLDFEKPQVEKLQFYFVKTDVKGAYDTIPHSKLDEVISKVINPNANEVYCIRRYATVSVDPTGRIIKSFKRHVSELADVLPNMKQFVSNQQEKNLLRNTILVEQNLLLNESSVKLLAVFQQIIRSHILRIKDRYYMQCCGIPQGSMLSTILCSLCYGDMENAMLGGIQKNGVLMRLIDDFLLVTPHLDQAKTFLRTLAEGIPQYGCSISPQKTVVNFPVDDIPECSEVEQLPSHCLFRWCGLLLDTQTLDVYYDYSSYACTSIRSSMTFCHSSAAGKYMKQKLIRVLRLKCHSLFLDLKVNSLRTVCINTYKIFLLQAYRFHACVVQLPFGQRVMNNPPFFLTVISDMAPCFYTTFKAKNKDLTRGYKDVSCQFNFEAVQWLSYQAFLTKLHNHKVLYKCLIGPLQNCKMQLSRRLSQDTIELLKSVTDSSLHKDFSCIMD
Protein: Met75Ca (Met75Cb) (Q9V449)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Prolyl 4-hydroxylase alpha subunit domain-containing protein
- Uncharacterized protein
- Cuticular protein 49Ah
- RH37844p
- NFU1 iron-sulfur cluster scaffold homolog
- Accessory gland protein 98AB
Sequence:
MNVFNGFLLVFLGLALSSVDAQIATRQETSEDKACGPHAYYNYARHTCLPF
Protein: Salivary glue protein Sgs-4 (Q00725)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Salivary glue protein Sgs-3
- Salivary glue protein Sgs-5
- Ecdysone-induced gene 71Ee
- Salivary glue protein Sgs-7
- Salivary glue protein Sgs-8
- Sgs5bis
- Salivary gland secretion 1
- Uncharacterized protein, isoform A
- Glycosyltransferase family 92 protein
Sequence:
MRLELLVVLLVGLAALAPSGSTCCKTEPPRCETEPPRCETEPPRCETEPPRCETEPPRCETTTPKCETTPPTCRTEPPTCKTEPPTCRTEPPTCKTKPPTCRTEPPTCRTEPPTCKTKPPTCKTEPPTCKTEPPTCRTEPPTCKTEPPTCRTEPPTCKTEPPTCKTEPPTCKTEPPCEKHCTKRIKRHRTKRTKRSKSTKKIVHHHNRPGTTPESGCGCGSKNESGGGGSGCILKDLLTPKCPDSKPKPQASPKCKSDPKPKAASKTTSKPKPKACDSGKKNTTKKPRKTQPQKGGC
Protein: Uncharacterized protein Rv0559c (P9WKL3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- 2-heptyl-1-hydroxyquinolin-4
- Menaquinone reductase
- Probable conserved transmembrane protein
- Calcium dodecin
Sequence:
MKGTKLAVVVGMTVAAVSLAAPAQADDYDAPFNNTIHRFGIYGPQDYNAWLAKISCERLSRGVDGDAYKSATFLQRNLPRGTTQGQAFQFLGAAIDHYCPEHVGVLQRAGTR
Protein: Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] (Q66K74)
Organism: Homo sapiens (Human)
Function: Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).
Subcellular location: Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Note=Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules. {ECO:0000250}.
Interaction partners:
- Ras association domain-containing protein 1
- Leucine-rich PPR motif-containing protein, mitochondrial
- Sequestosome-1
- Microtubule-associated protein 1 light chain 3 beta
- Microtubule-associated protein 1 light chain 3 alpha
- Ubiquitin-like protein ATG12
- Beclin-1
- Autophagy protein 5
- GABA type A receptor associated protein like 1
- Ubiquitin-like modifier-activating enzyme ATG7
Sequence:
MAAVAGSGAAAAPSSLLLVVGSEFGSPGLLTYVLEELERGIRSWDVDPGVCNLDEQLKVFVSRHSATFSSIVKGQRSLHHRGDNLETLVLLNPSDKSLYDELRNLLLDPASHKLLVLAGPCLEETGELLLQTGGFSPHHFLQVLKDREIRDILATTPPPVQPPILTITCPTFGDWAQLAPAVPGLQGALRLQLRLNPPAQLPNSEGLCEFLEYVAESLEPPSPFELLEPPTSGGFLRLGRPCCYIFPGGLGDAAFFAVNGFTVLVNGGSNPKSSFWKLVRHLDRVDAVLVTHPGADSLPGLNSLLRRKLAERSEVAAGGGSWDDRLRRLISPNLGVVFFNACEAASRLARGEDEAELALSLLAQLGITPLPLSRGPVPAKPTVLFEKMGVGRLDMYVLHPPSAGAERTLASVCALLVWHPAGPGEKVVRVLFPGCTPPACLLDGLVRLQHLRFLREPVVTPQDLEGPGRAESKESVGSRDSSKREGLLATHPRPGQERPGVARKEPARAEAPRKTEKEAKTPRELKKDPKPSVSRTQPREVRRAASSVPNLKKTNAQAAPKPRKAPSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATPSLELGPIPAGEEKALELPLAASSIPRPRTPSPESHRSPAEGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTEVDESLSVSFEQVLPPSAPTSEAGLSLPLRGPRARRSASPHDVDLCLVSPCEFEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGAEETPPTSVSESLPTLSDSDPVPLAPGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPPKTARQTENVSRTRKPLARPNSRAAAPKATPVAAAKTKGLAGGDRASRPLSARSEPSEKGGRAPLSRKSSTPKTATRGPSGSASSRPGVSATPPKSPVYLDLAYLPSGSSAHLVDEEFFQRVRALCYVISGQDQRKEEGMRAVLDALLASKQHWDRDLQVTLIPTFDSVAMHTWYAETHARHQALGITVLGSNSMVSMQDDAFPACKVEF
Protein: Pejvakin (Protein sirtaki) (Q0ZLH2)
Organism: Mus musculus (Mouse)
Function: Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:26544938}. Cell projection, cilium {ECO:0000269|PubMed:28209736}. Note=Associates with the peroxisomal membrane; it is unclear whether it is embedded or just associated with the peroxisomal membrane (PubMed:26544938). Localizes to ciliary rootlet (PubMed:28209736). {ECO:0000269|PubMed:26544938, ECO:0000269|PubMed:28209736}.
Interaction partners:
- TRIO and F-actin-binding protein
- Gasdermin-C
- Xin actin-binding repeat-containing protein 2
- Spectrin alpha chain, non-erythrocytic 1
- Spectrin beta chain, non-erythrocytic 1
- Transmembrane protease serine 3
- Glutaredoxin domain-containing cysteine-rich protein 1
- Gasdermin-D
- Myosin-IIIa
- Gasdermin-C3
Sequence:
MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRCKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRSNHIVNDVGINVTGSDSIAVKASFGVVTKHEVEVSTLLKEITARKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGREKAIVFPAHTTIAFSVFELFIYLDGAFDICVTSVSKGGFEREETTTFAMFYRLRNILFERNRRVMDAISRSQLYLDDLFSDFYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNLKRETVYGCFQCSVDGVKYVRLHAVPCFDIWHKRMK
Protein: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) (P53596)
Organism: Caenorhabditis elegans
Function: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03222}.
Interaction partners:
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Putative succinate dehydrogenase cytochrome b small subunit, mitochondrial
- 2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Sequence:
MLSQQIANNARTLQKGAARFYNSTYNNLKINKDTKVIVQGFTGKQGTFHGKQMLEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSAIEEAMDAEIPLVVCITEGIPQHDMVRVKSRLLKQNKTRLVGPNCPGIISADQCKIGIMPGHIHKRGCIGIVSRSGTLTYEAVHQTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKGIILIGEIGGSAEEEAAAYLKEHNSGANRKPVVSFIAGVTAPPGRRMGHAGAIISGGKGTAADKINALREAGVVVTDSPAKLGTSMATAFLGKI
Protein: Nonsense-mediated mRNA decay protein (PIN domain-containing protein) (G5ECF1)
Organism: Caenorhabditis elegans
Interaction partners:
- DNA/RNA-binding domain-containing protein
- UPF3 domain-containing protein
- PIN domain-containing protein
- Serine/threonine-protein kinase smg-1
- Nonsense-mediated mRNA decay factor SMG9
- Nonsense-mediated mRNA decay factor SMG8
- Regulator of nonsense transcripts 1
- MIF4G domain-containing protein
- 5'-3' exoribonuclease 1
- Nuclear cap-binding protein subunit 1
Sequence:
MQKSDEVTEKFKRYCNQLEKYGQTENVHSPVMAMLRRKGRKQLIEIMKRDGDCTSSINKLWIVGYYHPFQFFIRDKEKNMAIAVLLTMFCGELQEMLSLPDDKYPALWNMYIGDFHRYMPDEEIQKCLAVGYYSRAIDLDPNQGRAFHVLAGLRADLNVAQKLRLMILGQLADAPYKKGTELLEYLKFPQKESTDKLMVDFVIWALNEKSKRMDYQMTGIKIVNEFKAEIEQKLEFDWSLIMSTCRLASKLAMKKFGFQQFYNCFDTISTLYITIYSRTISSKCLLAEAISWISDSAEILGHLDEQKNEPHFQKLSVFAKTKWNELNDLVMNHINSVFTSMSLTINPSISMTSFLLNGPISEPNVEFLSQLINYLVSVEFPPMEIIHDREESGPLLRRINQSEQKRLDIQIKTQNDEVNREDWRPVYVLMDYDVIVDKIRIALKIWDIDDFICILPSTVLDELDYQKTKNRAVRPVIRALMELQAEGKIVLKKCDNERSCAEQLVQSARRSAEDHKHIVAFLCKNPSEQKEMEGVTFYDIDQFYMKYLE
Protein: Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (P48751)
Organism: Homo sapiens (Human)
Function: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29167417}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform CAE3]: Cell membrane {ECO:0000305|PubMed:7923606}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPHSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV
Protein: Mitogen-activated protein kinase MKC1 (MAP kinase MKC1) (EC 2.7.11.24) (Q5AAG6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Serine/threonine protein kinase component of the cell integrity pathway, a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. Participates in cell wall construction, azole resistance, and host interaction. Required for the signaling for invasive filamentous growth and biofilm formation, and plays a crucial role in virulence.
Interaction partners:
- mitogen-activated protein kinase kinase
- Dual specificity protein tyrosine phosphatase CCP1
- Rlm1p
- Transcription factor MBP1
- Tyrosine protein phosphatase
- protein-tyrosine-phosphatase
- cAMP-dependent protein kinase
- Serine/threonine-protein kinase SCH9
- cAMP-dependent protein kinase
- Transcriptional regulator
Sequence:
MDQQEAPIYYGRSVNKVYNQEFIIDSRFKIVKELGHGAYGIVCSAKYDNGSKKVPDSNNGNASSSANASFVAIKKITNIFSKNILCKRALRELKLLQFFRGHKNITCLYDLDIIPNPMTGEFNEIYLYEELMECDMHQIIRSGQPLSDQHYQSFIYQVLCGLNFIHSADVLHRDLKPGNLLVNADCELKICDFGLARGFSENPDENAGFMTEYVATRWYRAPEIMLSFTNYTKAIDIWSVGCILAELLGGKPLFRGKDYVDQLNQILMILGTPPESTLQRIGSHRAQNYVRSLPITRKASYEELFPDANPLALDLLERMLTLDPRERITVRDALNHKYLELWHDPKEEIECQVKFDFKSFETVDGLDEMKQLIMDEVQKFREFVRKPIEEQQRIQMQLHMQKREEQRQEEEEKELLEQQRQFPAQESMDISQTPYNNLETNIGTPQVEDDYPRPQELDEFTFSNLESSSSMNLFQDMAKPSGEEYIKLEEELGFGLDGAMFNNYCNDHQ
Protein: Meiotically up-regulated gene 122 protein (O74444)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Sorting nexin-12
- PXA domain protein 1
- PX domain-containing protein C1450.12
- Uncharacterized protein C663.15c
Sequence:
MYRKWDLCITRHLLPYIEHSVIPIIALLVLSLIFYILYICFGTTSYILSGIILGAYVNSLFHNNHSVILNIKHPELGEPLKPYQTPLPPELEAPLQLLISKLTQHYINGWYKHVSEDPSFIREVQSTIEYIMRQFYAYVSSQESSHIIYELLKNAISTTTLVLSDLNHFRSKKIPLTEFALRYPESAVSKLLDQASIERTLRAQASAMIVKFSRPEDSACLPLHCLLREVLAMQVFKRITTHCSSPRFVNRCIILYFSSSEDKSDCLAKKNYVNKCLMAKALKDYPVHTNIDPDAGKLSFDDAFYEAHIELHYQFLKEASLNTLIKDKKMLKFIITVRPVHLHVSPWVVYRRYRGFKTLYYLLKKQSARNGRAVPSFPVWRGNTYEKFREGLYFFIEALLHDSHFATNVDVRKFFAKSMRSHPLVDDIYNGFDVDKKHQSSSVPTLPNLTNISRVLSNKTSKSAKPKRSERTGLLSHQSTLAPEPLSQQRDSFELCTTGYRDTGSCTSDDEDSIHEPYRPASTQPTENPPAMPDHNGSPTTEPPKPNAFELKEERLKEIISGGFALVDELCSLNSKLWFFRKSVLTIMKTTVLHGPGRFSAQVERMLKNQIYDKLSNTQLVGDLLTSLILNVWPDEKKAMESHSTRAHRRSTESKISFDSEADSLFEEASKSVPEDPVSVFCDEESDESLRLRAEKTLVENALSENFTLMLGQSTSEESLKIIFELLQEPQFVQGFLAHLLSNALRSII
Protein: Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1) (P27169)
Organism: Homo sapiens (Human)
Function: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Subcellular location: Secreted, extracellular space.
Interaction partners:
- Apolipoprotein A-I
- Clusterin
- Apolipoprotein E
- Cholesteryl ester transfer protein
- Apolipoprotein A-II
- Phosphatidylcholine-sterol acyltransferase
- Haptoglobin-related protein
- Serum paraoxonase/lactonase 3
- Apolipoprotein B-100
- Apolipoprotein C-III
Sequence:
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
Protein: Helix-loop-helix protein 13 (Fer3-like protein) (Nephew of atonal 3) (Q20561)
Organism: Caenorhabditis elegans
Function: Transcriptional activator (By similarity). Shown to have a role in the negative regulation of exit from L1 arrest and dauer diapause dependent on IIS signaling (insulin and insulin-like growth factor (IGF) signaling). Hypodermal expression is regulated by IIS/daf-16 while neuronal expression is not under the control of IIS/daf-16.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q64305, ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm {ECO:0000250|UniProtKB:Q64305}.
Interaction partners:
- Headcase middle domain-containing protein
Sequence:
MTASSSGCGGLPVSQCPSYSSLSKLFFMDSSYDSYYCEEPEERQTASIRERKRMCSINVAFIELRNYIPTFPYEKRLSKIDTLNLAIAYINMLDDVLRTPEDSGQYIQKCVHMARTGQIGAPAWSTSDLLARLNWIKWRRLGIEPIA
Protein: Iron(III) enterobactin esterase (EC 3.1.1.108) (Q9I0F2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the hydrolysis of ferric enterobactin (Fe-Ent). Hydrolyzes Fe-Ent into three molecules of 2,3-dihydroxybenzoylserine (DHBS) still complexed with ferric iron. Iron reduction is necessary to obtain complete release of the metal from DHBS. It can hydrolyze salmochelin S4 (diglucosyl-C-Ent) but is not involved in iron acquisition by this siderophore.
Subcellular location: Periplasm {ECO:0000269|PubMed:30086222}.
Interaction partners:
- Ferric enterobactin receptor
- Sensor protein PfeS
- Pyochelin synthase PchD
- Phenazine biosynthesis protein PhzD1
- Pyochelin synthetase PchE
- Ferric enterobactin receptor PirA
- Probable non-ribosomal peptide synthetase
Sequence:
MRTSLLVAALGLALAAALPGGAPLAQPDPEATMDRSLLQRQDLPYRFSAVDLDSVDGQRHYRLWLGRPLQAPPAAGYPVVWMLDGNAAVGALDESTLRRLADGDAPLLVAIGYRTPLRIDRAGRTFDYTPASPGQADQRDPLNGLPSGGADAFLDLLRDGMRPAVAAQAPLDTARQTLWGHSYGGLLVLHALFTRPGEFARYAAASPSLWWRDGAILGERAGLEQRLRGKRAELLLWRGSAEPASPRGSLKAEPGQAMARLVDDLRRVAGLTLDFQPLDGLGHGETLGASLRLLLARPAVERQR