wanglab/gogpt-training-data huggingface dataset:
Protein: MHC class I antigen (V9HVU9)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
AAALTMIQTRAGPHSMRYFETAVFGPGLGEPRFISVGYVDNTQFVSFDSDAENPRSEPRSPWMEQEGPEYWERETQIAKDNEQSFGWSLRNLIHYYNQSKGGFHTFQRLSGCDMGLDGRLLRGYLQFAYDGRDYIALNEDLKTWMAADLVALITRRKWEQAGAAELYKFYLEGECVEWLRRYLELGNETLLRTDPPKAHVTRHPRPAGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPLGKEQNYTCRVHHEGLPEPLTLRWEPPPSTGSNMVNIAVLVVLGAVIIIEAMVAFALKSRRKIAILPGPA
Protein: Tetratricopeptide repeat protein 19 homolog, mitochondrial (Q8SYD0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for mitochondrial complex III formation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21278747}.
Interaction partners:
- Zinc finger FYVE domain-containing protein 26 homolog
Sequence:
MLVRNICKFTQVMGRFRVVVNPRDYCHLAPLKRSRYHQRSEFGCRPLCSNAAGYEVSWAAPPASGSSGGMFWAFSAAFTLNLFGGADEKEETPEEKLIKTIKRSILCIQREQYDKAEQMLHLALRMAQDIQSKDGITYVFDLMANLAMEREQFKKAEKIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKLLEKMPDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTLINVYGAVNDASVTILNNISVAYVNLEKYAEARETLLEAMELTKELKDATQEGILQANLGLVYLREGLMSQAENACRLAWKLGKQHQNPDAVEQAEYCLNEIKTTLNGEKRQ
Protein: FKBP12-associated protein 1 homolog (O74853)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play a role in transcription regulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi apparatus {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000250}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase
- Uncharacterized protein C126.13c
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein eL8
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL22
Sequence:
METSKNPSDLPKKPANVKKNRRRFQKSQKKSISPSSGSELPNFKTTISQNNEEVKTSLKEDSSKFHPSASAPIFVPTSSVQLNVSKNNGHKASDIVDAVSSKDEELRKHAKGEGKRSKNRKRSSKHSEKQAVDLKSSNSSQETSSSKGSVNNKSERSREAKSRMPKNSKEIKKGLDLSKLDMTSRMIVELKNRLYECSVCTDTINPSTSIWSCGTCYHVFHLSCIRKWCKNSIEQRNEDAWRCPYCQSNQTETSLHYLCWCGKQEKPEFVKNLVPHSCGDPCGKTRGQDCEHPCPLLCHPGPCPPCTATVEKFCLCGKESIHARCSNISKVNTEPFRCENVCDELLPCGEHTCKKRCHSGLCGACFEPINAKCYCGLHSKTYPCSSLPSPSISKKDENGSVKEWFGYYSCNNPCTLFFDCGLHKCSKTCHPISETRAHCPFATDVLTKCPCGKEDISFLLKGHERKSCSDPIPTCENICGKLLSCGHRCKYKCHLGSCGTCSETLTIPCRCTANEVQVTCEQLQNGFIPTCERLCTILLSCGRHQCNKKCCSGYSKAQTRLARRPKGAKLRYHLLTEEFEEEHICFRPCNKKLSCGNHFCQHMCHRGPCPRCLEASFEELPCTCGRTRLYPPVACGTPIPDCPYLCVLPKSCHHPQVKHNCHPTSEPCPPCPYFVKKRCLCGKHILENQPCYRENVRCGELCNKLLSCKTHFCEKLCHPDGECESSCKKECGKRRMYCEHVCQSPCHAGHPCDERIPCKAPLEVSCECGRIRKKVTCDASYDNPDPQHKVSCTLECSQQQRNKLFAEALNIKTDRRSNDVAQYTKSLLVFYGKHSDFADEVESLLRNFVNNKASSFRFPSMRREQRAFVHMFAKLLGLESVSFDPEPKRNVMVYNKGEAKLPNMLLKEANLYHLQHPEIPLKPDSLLGPEEENATASHIDGSSNASDSGYNAFVLKELLKEVNDESAIFSVLDDIVDFNHLTWSILFGENYIILKPLNTDLIVNKTGKLVALRPLVNRRLADAGIASRCEICEINDKNEIVKTRSQRIHSKKKAFLSLVPDKSIGVINRYKELATEL
Protein: Cytochrome b5 (B7GCG7)
Organism: Phaeodactylum tricornutum (strain CCAP 1055/1)
Function: Hemoprotein that functions as an electron carrier for membrane bound monooxygenases involved in sterol biosynthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:30478288}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSAEKEYILDEISQHTTTESCWLIIGNASNGGPKVYDVTKYLDDHPGGAEVMLDVAGQDADEFFEDIGHSKEARAELKNYLVGNFKIDAATLAKMKADAEAKAQQKNSGTGIMLIVLMALFAIAYGYYQTQMK
Protein: Heat shock 70 kDa protein C (P27420)
Organism: Caenorhabditis elegans
Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
Subcellular location: Endoplasmic reticulum lumen.
Interaction partners:
- Endoplasmin homolog
- Hypoxia up-regulated protein 1
- J domain-containing protein
- Hypoxia up-regulated protein 1
- Serine/threonine-protein kinase/endoribonuclease ire-1
- Calreticulin
- Mesencephalic astrocyte-derived neurotrophic factor homolog
- DnaJ homolog subfamily C member 10
- DnaJ homolog dnj-20
- Thioredoxin domain-containing protein
Sequence:
MKTLFLLGLIALSAVSVYCEEEEKTEKKETKYGTIIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFSGDQGDRLIGDAAKNQLTINPENTIFDAKRLIGRDYNDKTVQADIKHWPFKVIDKSNKPSVEVKVGSDNKQFTPEEVSAMVLVKMKEIAESYLGKEVKNAVVTVPAYFNDAQRQATKDAGTIAGLNVVRIINEPTAAAIAYGLDKKDGERNILVFDLGGGTFDVSMLTIDNGVFEVLATNGDTHLGGEDFDQRVMEYFIKLYKKKSGKDLRKDKRAVQKLRREVEKAKRALSTQHQTKVEIESLFDGEDFSETLTRAKFEELNMDLFRATLKPVQKVLEDSDLKKDDVHEIVLVGGSTRIPKVQQLIKEFFNGKEPSRGINPDEAVAYGAAVQGGVISGEEDTGEIVLLDVNPLTMGIETVGGVMTKLIGRNTVIPTKKSQVFSTAADNQPTVTIQVFEGERPMTKDNHQLGKFDLTGLPPAPRGVPQIEVTFEIDVNGILHVTAEDKGTGNKNKITITNDQNRLSPEDIERMINDAEKFAEDDKKVKDKAEARNELESYAYNLKNQIEDKEKLGGKLDEDDKKTIEEAVEEAISWLGSNAEASAEELKEQKKDLESKVQPIVSKLYKDAGAGGEEAPEEGSDDKDEL
Protein: RfeF (C8VLE0)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Actin-associated protein
Sequence:
MGFASKIANAQMSASNSGGVYGGAPPTSYTGGPPTGAGSQAGGYQPQQAPQQQQPPQQYQAYPGGSASGYPPQNAPYPPGPPGPPHAQAPGGQYGPPSGAGGAVGPATQQQLNAYRQLLISTIQEKSLQHFYPPDKLDRLVQGLSRDGPAKVNKIVNEFALPTEIAMDVIKLSLYDIVLYVDDSGSIEFEEKGVRKEQLKQILGIVATIASTFDEDGISLRFMNNDFMQNNIRSAQDVEQIISNIRFSGMTPLGSALRSKVLDPMIVGPARAGRLQKPVLVITITDGQPAGEPLDSVAQGIRYAVDEVSRSPFGRGAVAFQFSQVGNDTKARDFLGSLDNDPSIGGLIDCTSNFEVEQDEMSRANPPVHLTRELWCAKLMLGSIDSSYDTKDERGSGPSGAPPGPPPGQYGGYGQSGPGYGSSAPYNPGQQQPYSPAYPPHSQAPGGYAQPPPQGQYGGYSQPGPGYGSPAPYSSGQQQGYGSAPYPPSSQASGSYGQQQYGQRPGSQPGYPGQQPPYGQQPRY
Protein: Forkhead box protein J1 (Forkhead-related protein FKHL13) (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4) (Q92949)
Organism: Homo sapiens (Human)
Function: Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q61660}.
Interaction partners:
- DNA-binding protein RFX2
- Transcription factor RFX3
- Multicilin
- Uteroglobin
- Intraflagellar transport protein 88 homolog
- Surfactant protein C
- MHC class II regulatory factor RFX1
- Secretoglobin family 3A member 2
- Tektin-1
Sequence:
MAESWLRLSGAGPAEEAGPEGGLEEPDALDDSLTSLQWLQEFSILNAKAPALPPGGTDPHGYHQVPGSAAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQEPSAVPRAGPLTVNTEAQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRPPSTLLPTPEEQGELEPLKGNFDWEAIFDAGTLGGELGALEALELSPPLSPASHVDVDLTIHGRHIDCPATWGPSVEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPLFEAGDATLASDLQDWASVGAFL
Protein: Large ribosomal subunit protein eL43 (60S ribosomal protein L43) (Q6FRG6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Large ribosomal subunit protein eL38
- 60S ribosomal protein L6
- 40S ribosomal protein S30
- Large ribosomal subunit protein eL31
- Ribosomal protein L37
- S16a
- 60S ribosomal protein L8
- 60S ribosomal protein L27
- L2
- 40S ribosomal protein S26
Sequence:
MAKRTKKVGITGKYGVRYGSSLRRQVKKLEVQQHARYDCSFCGKKTVRRGAAGIWSCHSCKKTVAGGAYTVSTAAAATVRSTIRRLRDMVEA
Protein: Small ribosomal subunit protein bS1 (30S ribosomal protein S1) (P9WH43)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Binds mRNA, facilitating recognition of most mRNAs by the 30S ribosomal subunit during translation initiation (By similarity). Probably plays a role in trans-translation; binds tmRNA (the product of the ssrA gene). In trans-translation Ala-aminoacylated transfer-messenger RNA (tmRNA, product of the ssrA gene; the 2 termini fold to resemble tRNA(Ala) while it encodes a short internal open reading frame (the tag peptide)) acts like a tRNA, entering the A-site of the ribosome and displacing the stalled mRNA (which is subsequently degraded). The ribosome then switches to translate the ORF on the tmRNA, the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and thus targeted for degradation (By similarity).
Interaction partners:
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS7
- Elongation factor Tu
- Large ribosomal subunit protein uL3
Sequence:
MPSPTVTSPQVAVNDIGSSEDFLAAIDKTIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTEGVIPARELSIKHDVDPNEVVSVGDEVEALVLTKEDKEGRLILSKKRAQYERAWGTIEALKEKDEAVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYIGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNNLQKGTIRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVQVGDEVTVEVLDVDMDRERVSLSLKATQEDPWRHFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAVGDDAMVKVIDIDLERRRISLSLKQANEDYTEEFDPAKYGMADSYDEQGNYIFPEGFDAETNEWLEGFEKQRAEWEARYAEAERRHKMHTAQMEKFAAAEAAGRGADDQSSASSAPSEKTAGGSLASDAQLAALREKLAGSA
Protein: Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) (Trehalase 1) (AtTRE1) (Q9SU50)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of trehalose content by hydrolyzing trehalose to glucose.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17673210, ECO:0000269|PubMed:35088230}; Multi-pass membrane protein {ECO:0000255}. Note=Has extracellular activity when expressed in yeast. {ECO:0000269|PubMed:17673210}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus {ECO:0000269|PubMed:35088230}.
Interaction partners:
- Probable trehalose-phosphate phosphatase G
- Trehalose-phosphate phosphatase A
- Trehalose-phosphate phosphatase B
- Probable trehalose-phosphate phosphatase F
- Probable trehalose-phosphate phosphatase J
- Probable trehalose-phosphate phosphatase D
- Probable trehalose-phosphate phosphatase H
- Probable trehalose-phosphate phosphatase I
- Probable trehalose-phosphate phosphatase C
- Probable alpha,alpha-trehalose-phosphate synthase 10
Sequence:
MKSYKLNNPNLLISTHTHNKLFLSSSPFNLLFSFPSFIYLKQQRSLFFFFFFFLCFSFTTSMLDSDTDTDSGPVVATTKLVTFLQRVQHTALRSYPKKQTPDPKSYIDLSLKRPYSLSTIESAFDDLTSESHDQPVPVETLEKFVKEYFDGAGEDLLHHEPVDFVSDPSGFLSNVENEEVREWAREVHGLWRNLSCRVSDSVRESADRHTLLPLPEPVIIPGSRFREVYYWDSYWVIKGLMTSQMFTTAKGLVTNLMSLVETYGYALNGARAYYTNRSQPPLLSSMVYEIYNVTKDEELVRKAIPLLLKEYEFWNSGKHKVVIRDANGYDHVLSRYYAMWNKPRPESSVFDEESASGFSTMLEKQRFHRDIATAAESGCDFSTRWMRDPPNFTTMATTSVVPVDLNVFLLKMELDIAFMMKVSGDQNGSDRFVKASKAREKAFQTVFWNEKAGQWLDYWLSSSGEESETWKAENQNTNVFASNFAPIWINSINSDENLVKKVVTALKNSGLIAPAGILTSLTNSGQQWDSPNGWAPQQEMIVTGLGRSSVKEAKEMAEDIARRWIKSNYLVYKKSGTIHEKLKVTELGEYGGGGEYMPQTGFGWSNGVILAFLEEYGWPSHLSIEA
Protein: Motilin (Q9PRP6)
Organism: Gallus gallus (Chicken)
Function: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
Subcellular location: Secreted.
Interaction partners:
- Growth hormone secretagogue receptor type 1
- Appetite-regulating hormone
- Neurotensin.
- Cholecystokinin
- Uncharacterized protein
- Secretin.
- Pro-glucagon
- Neuromedin-U-25
- Pancreatic polypeptide
- Somatostatin
Sequence:
FVPFFTQSDIQKMQEKERNKGQ
Protein: Olfactory receptor 2J1 (Hs6M1-4) (Olfactory receptor 6-5) (OR6-5) (Q9GZK6)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MLMKKNASFEDFFLLLGFSNWPHLEVVLFVVILIFYLITLIGNLFIIILSYLDSHLHTPMYFFLSNLSFLDLCYTTSSIPQLLVNLWGPEKTISYAGCTVQLYFVLALGTAECVLLVVMSYDRYAAVCRPLHYTVLMHPRFCRLLAAASWVSGFTTSALHSSFTFWIPLCRHRLVDHFFCEVPALLRLSCVDTQANELTLMVMSSIFVLIPLILILTSYGAIARAVLSMQSTTGLQKVLRTCGAHLMVVSLFFIPVMCMYLQPPSENSQDQGKFIALFYTVVTPSLNPLIYTFRNKDVRGAVKRLMGWEWGM
Protein: T-complex protein 1 subunit beta (CCT-beta) (Q9W392)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Chaperonin containing TCP1 subunit 6
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit delta
- Uncharacterized protein
- Phosducin-like protein 2
- Eukaryotic translation initiation factor 2 subunit 1
Sequence:
MEMSLNPVRVLKNEAQEEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILRAVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQATQVALEALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGSGELKSIQIIKKSGGTLGDSFLDEGFLLDKKPGVHQPQRIENARILIANTPMDTDKIKVFGSSIKVDSLAKIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADFDGIERLAYCTGGEIVSTFENPSLVKLGECDVIEQVMIGEDTLLRFSGVKLGEACTIVIRGATQQILDEADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAIADNAGYDSAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMILRVDNIIRCAPRRRVPDRGYC
Protein: Cellular tumor antigen p53 (B0S577)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU003304}. Nucleus {ECO:0000256|RuleBase:RU003304}.
Interaction partners:
Sequence:
MSQSSTADEGPTFEHLWSTLEPDSTYFELPQAGHSGDRASSSLPGNRAEVCMDVYHMRDMRDMNDNVMSQYSLLSSSMDQGLGNRAASTSPYSSETTSNVPTPSPYSQPNSTFEAMSPAPAIPSNTDYPGPHNFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKLASSPPNGSVIRAMPIYKKAEHVTEVVKRCPNHELGRDFNESQTAPASHLIRVEGNNLCQYVDDPVTGRQSVLVPYESPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHFREQQALNESVAKNGNANKRNFKQTPTNITGPSINIKKRRHGEEEMYYIPVRGRENFDILMKIKDSLELVEFVPQQLVDSYRQQQQQLLQRQNHVASPSSYGTLNNMNKIHGPISKLPSVNQLVTQQTQQSAGPSASLSHMGANMLGGHHMQSNGDVNGAHQSQSIVSTSHCTPPPPYNPDPSLVRTQPLGLSGIPFLSEQFLNQPGLPKLYRLLHVSGTPECVPPSDSYYGGPWGPEDS
Protein: YTH domain-containing family protein (J3QR07)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKRIVSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQVIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYPPEFHQRPGYLKDPRYQEVDSFTNLIPNRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMPPYPGMEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERLCDRDRDRGERGRYRR
Protein: Nucleoporin POM152 (Nuclear pore protein POM152) (P150) (Pore membrane protein POM152) (P39685)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. POM152 is important for the de novo assembly of NPCs.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.
Interaction partners:
- Nucleoporin POM34
- Nucleoporin NUP188
- Nucleoporin NUP170
- Nucleoporin NUP157
- Nucleoporin NIC96
- Nucleoporin NDC1
- U3 small nucleolar RNA-associated protein 8
- Nucleoporin ASM4
- Nucleoporin NUP53
- Nucleoporin NUP133
Sequence:
MEHRYNVFNDTPRGNHWMGSSVSGSPRPSYSSRPNVNTTRRFQYSDDEPAEKIRPLRSRSFKSTESNISDEKSRISERDSKDRYINGDKKVDIYSLPLISTDVLEISKQRTFAVILFLIIQCYKIYDLVILKSGLPLSGLLFKNYRFNFISKYFIIDSFFLYVLPSFNIPRLTFKPWVVYLQILAMLLLNIFISSDHEFVLISLIMTTWRKLYTKELSVTGSAINHHRIFDSSAHFKGALTIKILPENTAMFNPLHESYCLPMDTNLFKINSIDVPIRINSTEEIEYIELEYRDLYTNSVELRSLSKKDFKIIDNPKSFLKKDQSVLKSHSNDFEEGSTIRYLAVTLQDIGFYQIKKIVDSKKLNLKIHQSHLVVPYCPIASITGTGSNDRCIGDSDNVSFEIQGVPPMKLAYSKIVNGQTFSYVDSSLQPEYFESPLQSSKSKQSFTQGELNDLKWGRNQPVNINLDSSITQDGKFAYKIDKITDGLGNVVDFTSLPEELKKRYDLSYNFNVHEVPRAALEERFDPKSPTKRSIAIVFEEIKNWISDIPYVISLSYTDAQDKSKKIMNVTTDSLTKVLQADLPGSYNLEYIESKFCPGEIVGKSNVLVTMPVAPTMEVKSFPILDQCVGQVGLNFELSFTGAPPYYYNTKIYKLENGERKLYDAKRYTSEGTRNRFSYSPPKEGNYEIVFDTVSNKLFTEPIKLEPVKEYTFKTSMRVKPSASLKLHHDLKLCLGDHSSVPVALKGQGPFTLTYDIIETFSSKRKTFEIKEIKTNEYVIKTPVFTTGGDYILSLVSIKDSTGCVVGLSQPDAKIQVRRDIPSAAFNFFEPIKEAKIKHGSVTEIPLKLSGEGPFTVKFKHMDYDGNIVKEFENKFQNSYKPALKVSKEGLYQLVDIRDSSCQGNVIYRNSLYKVSFLEKPKFAIQDNHHITKVTENLFSKEEVCQGMEGTVDLALFGSPPFILEYDLMAPNGHISTKKIQVATKYASLKLPNQIPGEYITTIKAIFDGNYGESDIHFREHQSELIIKQTVHPIPDVAFADGGKTLRACAANVDQISFLEPINLKFLQGESPFSITFSVYHESTSRTDQYTIDNIDSENFSFEKLYEGMKLGNHAITIDSVVDANGCVNSLISGPRNQILVSITDAPKIHILDPSTEYCVGDYVAYQLNGVAPFMIKYEFNGIPLKSKERSSQFVRLASEPGIISITSLQDSSSQCIVDFTNPKLKSEFDDLSLNIHPIPSVTVSQGNYVTEDIREGDQAEVIFSFEGTPPFSLTYVRTEETDGKHGKRRSQVVETHKVTDIYSHEYKVITSLQGTYEAIEITDAYCFAKNDLFFNN
Protein: SOX domain-containing protein dichaete (Protein fish-hook) (Q24533)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for segmentation and CNS development. May modulate the actions of other transcription factors, including gap and pair-rule proteins.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- RH05790p
- IP01435p
- Lateral muscles scarcer, isoform B
- Dorsal interacting protein 4
- Sox21a, isoform B
- POU domain protein CF1A
- SoxNeuro, isoform B
- POU domain protein 2, isoform B
- Protein nubbin
Sequence:
MATLSTHPNYGFHLGQAQGLEDYAPQSQLQLSPGMDMDIKRVLHYSQSLAAMGGSPNGPAGQGVNGSSGMGHHMSSHMTPHHMHQAVSAQQTLSPNSSIGSAGSLGSQSSLGSNGSGLNSSSGHQSAGMHSLATSPGQEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKNPLTAGPQGGLQMQAGGMGQQKLGAGPGAGAGGYNPFHQLPPYFAPSHHLDQGYPVPYFGGFDPLALSKLHQSQAAAAAAVNNQGQQQGQAPPQLPPTSLSSFYSGIYSGISAPSLYAAHSANAAGLYPSSSTSSPGSSPGTITPNGMDGSMDSALRRPVPVLY
Protein: Protein YIPF3 (Killer lineage protein 1) (Natural killer cell-specific antigen KLIP1) (YIP1 family member 3) [Cleaved into: Protein YIPF3, 36 kDa form III] (Q9GZM5)
Organism: Homo sapiens (Human)
Function: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein. Note=Localization to the cytoplasm or to the cell membrane is developmentally and ontogenetically regulated.
Interaction partners:
- Protein YIPF4
- Protein YIPF1
- Protein YIPF2
- Protein YIPF5
- Sciellin
- Protein YIF1A
- Protein YIPF6
Sequence:
MATTAAPAGGARNGAGPEWGGFEENIQGGGSAVIDMENMDDTSGSSFEDMGELHQRLREEEVDADAADAAAAEEEDGEFLGMKGFKGQLSRQVADQMWQAGKRQASRAFSLYANIDILRPYFDVEPAQVRSRLLESMIPIKMVNFPQKIAGELYGPLMLVFTLVAILLHGMKTSDTIIREGTLMGTAIGTCFGYWLGVSSFIYFLAYLCNAQITMLQMLALLGYGLFGHCIVLFITYNIHLHALFYLFWLLVGGLSTLRMVAVLVSRTVGPTQRLLLCGTLAALHMLFLLYLHFAYHKVVEGILDTLEGPNIPPIQRVPRDIPAMLPAARLPTTVLNATAKAVAVTLQSH
Protein: Putative glutamine amidotransferase YafJ (EC 2.4.2.-) (Q47147)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
- tRNA
Sequence:
MCELLGMSANVPTDICFSFTGLVQRGGGTGPHKDGWGITFYEGKGCRTFKDPQPSFNSPIAKLVQDYPIKSCSVVAHIRQANRGEVALENTHPFTRELWGRNWTYAHNGQLTGYKSLETGNFRPVGETDSEKAFCWLLHKLTQRYPRTPGNMAAVFKYIASLADELRQKGVFNMLLSDGRYVMAYCSTNLHWITRRAPFGVATLLDQDVEIDFSSQTTPNDVVTVIATQPLTGNETWQKIMPGEWRLFCLGERVV
Protein: Photoreceptor cilium actin regulator (A6NGG8)
Organism: Homo sapiens (Human)
Function: Plays an essential role for normal photoreceptor cell maintenance and vision.
Subcellular location: Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:20398886}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q6PAC4}.
Interaction partners:
- Protein eyes shut homolog
- Interphotoreceptor matrix proteoglycan 2
- Photoreceptor disk component PRCD
- Ceramide kinase-like protein
- Zinc finger protein 513
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
- Cyclic nucleotide-gated channel alpha-1
- Retinol dehydrogenase 12
- Tubby-related protein 1
Sequence:
MGCTPSHSDLVNSVAKSGIQFLKKPKAIRPGCQGGSERGSIPLLVKNSTCYDAGEGLAEEQPSPRRNQTTAKGLCQLMGDPASGKRKDMEGLIPGTKTSSSQLNKSQSHMAKDIPFKTQGSHGSQGADFSGDESEESSTQDTSKWKRTAKCHTSSTQSHCYQTIHPAHEPEGKVDFPEPLVKAHQQAYTYLHSSLSKYEAILCIIHQATQTRELLQPMVSFLLLCFEEISQLLGEISKDGEVLLQEVREDLAWPLKKREPQEQPNLLQQLLQYTVSKLQVLNGTVASLTGSFLEGSSSYLHSTATHLENKLSTKRNVDERLLRALRQLESLASGCGDPGVQGLPLCSEDSGIGADNESVQSVDKLGKQTSWDLAPEPEEWKSVTSPHTEARQSGHTWQQSPFCLGSGRPQDCLLSGAPMAKVQPRAQDEARSPCLSSTSPENITSPPLKLGTSTPCDSFGIGVSVEPHLSKTSRPMDASSLSDSEDSSPEEEEEDKMSSMSLCAWQEKTPHSRPQSSPADRESPFQARTRRLRSLQAQEMILKMKESISERIKFVPVPCGHQDWSEEEEGRTVVPPRPSTVSGSRRAPERQTRSQSESCLQSHVEDPTFQELRRVQRDLSQKLEAFYALGAKGQGQSQEQILQPRAAAVWPNGTCRVSPSNTTSRLKASLTKNFSILPSQDKSILQKCNPHPEDEQGKAGKLPNAIPSGEVSEAAKATDWNVRGCPTRTSVKKLIETFSPTESLRMLGDSKDAGASPCLRNCIMPPRFPKYTGLAPLYPKPQISPASGRESLKMGIGWKPLAPIFPPLPKAEAAKSEELSCEMEGNLEHLPPPPMEVLMDKSFASLESPESSKSTENSPKETQEPGPGEAGPTRRTWASPKLRASVSPLDLLPSKSTASLTKPHSTGPGSGRSSCQPRKPALDLSSPPATSQSPEVKGGTWSQAEKATSLYRQPRKAIAWHHSGPPSGQNRTSESSLARPRQSRERSPPVGRKASPTRTHWVPQADKRRRSLPSSYRPAQPSPSAVQTPPSPPVSPRVLSPPTTKRRTSPPHQPKLPNPPPESAPAQCKVPSPPTQHPEASPPFSIPSPSPPMSPSQEHKETRDSEDSQAVIAKVSGNTHSIFCPATSSLFEAKPPLSTAHPLTPPSLPPEAGGPLGNPAECWKNSSGPWLRADSQRRAALCALNPLPFLRRTASDRQPGGRPQPPTLDPTSTSYESQLGQNSSSEESPKKDTEPGSSPCSPELQGGTRRASPPEFCVLGHGLQPEPRTGHIQDKSQPEAQPQQEEVS
Protein: BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Q9UQB8)
Organism: Homo sapiens (Human)
Function: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Interaction partners:
- Actin-binding protein WASF2
- Cell division control protein 42 homolog
- Epidermal growth factor receptor kinase substrate 8
- Actin-binding protein WASF1
- Vasodilator-stimulated phosphoprotein
- Abl interactor 1
- Adhesion G protein-coupled receptor B1
- Protein enabled homolog
- Abl interactor 2
- Disks large homolog 4
Sequence:
MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGREHGDGSARTLAGR