wanglab/gogpt-training-data huggingface dataset:
Protein: CCN family member 3 (Cellular communication network factor 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephro blastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH) (P48745)
Organism: Homo sapiens (Human)
Function: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts. Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification. Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway. Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q64299}. Cytoplasm {ECO:0000269|PubMed:15181016}. Cell junction, gap junction {ECO:0000269|PubMed:15181016}. Note=Localizes at the gap junction in presence of GJA1. {ECO:0000250|UniProtKB:Q9QZQ5}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- SPARC
- Insulin-like growth factor-binding protein 7
- von Willebrand factor
Sequence:
MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAFLQELELKTTRGKM
Protein: Large ribosomal subunit protein mL63 (Mitochondrial ribosomal protein 63) (Mitochondrial ribosomal protein L57) (Ribosomal protein 63, mitochondrial) (hMRP63) (Q9BQC6)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Interaction partners:
- Large ribosomal subunit protein mL50
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein mL52
- Large ribosomal subunit protein mL64
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL10m
- Large ribosomal subunit protein mL39
- Large ribosomal subunit protein mL65
- Large ribosomal subunit protein bL28m
- Large ribosomal subunit protein mL41
Sequence:
MFLTALLWRGRIPGRQWIGKHRRPRFVSLRAKQNMIRRLEIEAENHYWLSMPYMTREQERGHAAVRRREAFEAIKAAATSKFPPHRFIADQLDHLNVTKKWS
Protein: Glutamate synthase [NADPH] small chain (EC 1.4.1.13) (Glutamate synthase subunit beta) (GLTS beta chain) (P9WN19)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Glutamate synthase large chain
- Possible oxygenase
- Glutamine synthetase
- Carbamoyl phosphate synthase large chain
- Probable glutamine synthetase GlnA4
- Glutamine synthetase
- Probable glutamine synthetase GlnA3
- Glutamine--fructose-6-phosphate aminotransferase
- L-glutamate gamma-semialdehyde dehydrogenase
- Amidophosphoribosyltransferase
Sequence:
MADPGGFLKYTHRKLPKRRPVPLRLRDWREVYEEFDNESLRQQATRCMDCGIPFCHNGCPLGNLIPEWNDLVRRGRWRDAIERLHATNNFPDFTGRLCPAPCEPACVLGINQDPVTIKQIELEIIDKAFDEGWVQPRPPRKLTGQTVAVVGSGPAGLAAAQQLTRAGHTVTVFEREDRIGGLLRYGIPEFKMEKRHLDRRLDQMRSEGTEFRPGVNVGVDISAEKLRADFDAVVLAGGATAWRELPIPGRELEGVHQAMEFLPWANRVQEGDDVLDEDGQPPITAKGKKVVIIGGGDTGADCLGTVHRQGAIAVHQFEIMPRPPDARAESTPWPTYPLMYRVSAAHEEGGERVFSVNTEAFVGTDGRVSALRAHEVTMLDGKFVKVEGSDFELEADLVLLAMGFVGPERAGLLTDLGVKFTERGNVARGDDFDTSVPGVFVAGDMGRGQSLIVWAIAEGRAAAAAVDRYLMGSSALPAPVKPTAAPLQ
Protein: IQ calmodulin-binding motif-containing protein 1 (IQ motif-containing B1) (Zgc:101792) (Q5PRA5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Centrosomal protein of 290 kDa
- Nephronophthisis 1.
- Si:dkey-202c5.1 protein.
- Nephrocystin-3
- Protein fantom
- RPGR-interacting protein 1.
- Inversin
- Retinitis pigmentosa GTPase regulator a.
- Abelson helper integration site 1.
- Spermatogenesis-associated 7.
Sequence:
MGPSGDEIYPELKDLVEDTREISEDKFNDVLSKLKELLDLKSLGDQRDLEVCRLRLYTHGVLQYCSSSLRFRPARIQGGYAALTQIADLLSTCCVGLAAFRDIEVFSHEFLPSVVESLLFLAERLMNRALRDKAPSEMIRLFRKVFDSIGWLLRAHRHLIHHVLRCKHYESVQICEDDDVSIVTVTLWNDIFRTNSAVLAEMGNRALTDIMDDIVYKMSSSSNPVIGRAAVKTLVLILDHSSSTQQLIQRRYRGLSDLAEKDWRGKGFDSALDQLIDHLQLDVPWKEPKESSEECVRAACVIQAAWRAHLTRRRLKKLPRAVSTLQRSFREKRRQQQEHTERRRAEEELRHQVCLRRQRAMRLFRQHQLHLMEILPAGQVQRYLGELENKAALVIQRVWRGHRERRHFQQHKHILRRHRAAVTLQRAVLLFLKRRKAQRNILTPLKAPKGLTDSRRTELRKQIQEHISLHPSSVQSAEGSAELHQRAQSLLHRHLVNRASDRAQEQHRQALLAQINTDIELLLNAPSLRDVREEDVNLFLSRSCPVATRARQSHNALLQSMRLPWWRTLGDDLSNPEEPRKDYDIDIESLYLGGS
Protein: HnRNP K protein homolog (Q9V948)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKREMNDEGEGPQDQKRNRRNEETVRILIPSSIAGAVIGKGGQHIQKMRTQYKATVSVDDSQGPERTIQISADIESTLEIITEMLKYFEERDEDFDVRLLIHQSLAGCVIGKGGQKIKEIRDRIGCRFLKVFSNVAPQSTDRVVQTVGKQSQVIEAVREVITLTRDTPIKGAIHNYDPMNFDRVYADEYGGYGTGSGSTRPSQRGNNRNGGGAGGVAGGAAGNGGGFNAGGARGNAGGRGGRSASAAPGGAVAGAGMGQRDNPFINPWANGGGGDVDGFGNNAGGAGGFAGNSFGGGAGGPFGGGSFGNNGFGGGPSDFGGNSGNFGQAQGTNSLPSLGSFSQNQGGTSSLPSLGSFGQNPGGPGGLGNGLSGGANGGVGALGGANGAGFNAVGGANGGPNGSPNAATNVPQGHDPNNSTQVTIPKELAGAIIGKGGGRIRRIRNESSAYITIDEPLPNSNDRIITISGTPKQIQMAQYLLQQRLVSQSE
Protein: Adapter molecule crk (Proto-oncogene c-Crk) (p38) (P46108)
Organism: Homo sapiens (Human)
Function: Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
Interaction partners:
- Tyrosine-protein kinase ABL1
- Dedicator of cytokinesis protein 1
- Paxillin
- Rap guanine nucleotide exchange factor 1
- Breast cancer anti-estrogen resistance protein 1
- Proto-oncogene tyrosine-protein kinase Src
- E3 ubiquitin-protein ligase CBL
- Engulfment and cell motility protein 1
- Epidermal growth factor receptor
- Focal adhesion kinase 1
Sequence:
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS
Protein: Gametocyte-specific factor 1 homolog (Protein asterix) (Q8SWX0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons. Required for repression of transposons and neighboring genes in ovarian somatic and germline cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:23913921, ECO:0000269|PubMed:23913922}.
Interaction partners:
- Protein piwi
- Protein panoramix
- GH09064p
- Nuclear RNA export factor 2
Sequence:
MVYCPYNKEHKMLRKKLQQHILKCRVIYKDTVELMVCPFNSSHLIPEPQFFQHTQSCEDRNIIVHYQTSAPAVLSEDTRHAKIESEENWDDDESVPDYDPQVYCSRANIVREPNGLFPAQRRAFIEQEKRRHFGEDYEEEKKPRKAKARADLRPTPYEHRRPYSRRQ
Protein: ABC transporter C family member 3 (ABC transporter ABCC.3) (Q54JR2)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- ABC transporter G family member 8
- ABC transporter AbcH.1
Sequence:
MELEEVGVEANQPNNDQGSKKQNKNKDKKVKKEKKIGYGGKKSAEENSNFISWLTFSWADRFVVHCFRHVLQLSHIWDLASYDKSAYLAEKIAISWDVEIKKPKPSYIRAAFRAFGLYFVLSWFFYAIYAASQFVGPEILKRMVTFVLKSRSGISTEDPNMGYYYALIMFGSAMIGSVCLYQSNMISARTGDRLRSVIVLDVYRKAIKLSNSARANTSPGEIVNLMSNDAQRMVEVFQLVNNGVFALPQIIVCLALLYRAIGWPTFVGLGLMLAAVPFNGIAAKKLTEIRRHLVGFTDKRVKTTNEILQAIKIIKLYAWEDSFAKKVIERREAEIKLLFSFSRYRAMLIVIVAALPTAVSVLVFSSYYGYYKKLDAGEIFAALSYLNILRLPLGFLPIIVALGIQMKIAAQRVTDFLLLPEMKEISKIEDPSIENGIYIRDATLTWNQEKKEESFTLKNINFEAKGKTLTMIVGSVGSGKSSLIQAMLGEMDVLDGSVAMKGNVAYVPQQAWIINATLKDNILFGSPYDEAKYRKVLEVCALERDIELFPQGDLVEIGERGVNLSGGQKQRVSIARAVYSDSDVYILDDPLSAVDAHVGKHLFHRCFKGILKSKTVILAANQLNYLPFAHNTVVLKAGEISERGSYQQLINAQKEFSGLLQAYGVDESAVNEDVEDDKEIEESDNIVVEEKTKPTEKPKLQNKDGVLTSQEEREEGAVAMWVYWKYITVGGGFLFLMAFIFFLMDTGTRTFVDWWLSHWQNESTKNALAVAQGLEPSGLTDTQYLGIYIGVGMTSILISAGRNFLFFEYTVRASRALHHQLFNALLRAPMSFFDTTPLGRIINRFTRDLDGVDNLMATSISQFLVFFTTVVATLIIISIITPFLLVPLAPICIIFYFLQFFYRYTSRELQRLEAISRSPIFSHFSETLGGVVSIRAYRKKEENILTNQFRLDNNNKCYLTLQAMNQWLGLRLDLLANLVTFFACLFITIDRDTISAANVGLSLSYALSLTGNLNRATLQAADTETKMNSVERITHYIKGPVEALQIVEDHRPAPDWPPHGAITFDNLVMRYREGLDPVLKGISCEIKAKEKIGIVGRTGAGKSSIVLALFRLIEASEGAILIDGENIAKFGLKDLRRNLAIIPQDPVLFSGTLRENIDPFNEKTDDQLWSVLKDIQLHDVAKSLEGGLDSKVTENGDNWSVGQRQLLCLARALLRDPKILVLDEATASVDGHSDSLIQATIREKFSNCTILTIAHRLNTIMDSDRIIVLDAGKISEFDEPWTLLQNPAGLLNWLVEETGPQNAAYLRRLAQAKKDGVNIDQITPPISPTPEQKPFKNADIDNINSPPQQSLKAEDNPNPKALDNSGDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNDNDNDNDNSEAGDN
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F4HPR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ras-related small GTP-binding family protein
- Monomeric G-protein
- At3g14430
- Reticulon-like protein B5
- F7A19.25 protein
- T-complex protein 1 subunit eta
- Putative MO25-like protein At5g47540
- MO25-like protein At2g03410
- Putative MO25-like protein At4g17270
- At5g18940
Sequence:
MDDVAGLQEAAGTRFSQFELIGRGSFGDVYKAFDTELNKDVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYITEYYGSYLHQTKLWIIMEYMAGGSVADLLQPGNPLDEISIACITRDLLHAVEYLHAEGKIHRDIKAANILLSENGDVKVADFGVSAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFSRPLKEFVSFCLKKAPAERPNAKELLKHRFIKNARKSPKLLERIRERPKYQVKEDEEIPTNGPKAPAESSGTVRVAKDERGQGTSGTRLDKWLDKCFQVKTVRNAGWDFSIGGSQGAGTVRALKPPQARERRQEVNSNQTSQKTSRTSGSQLSSTFGVPEISEGGFNKRDSYQNDYQEEDDSSGSGTVVIRSPRSSQSSSMFRDQSSGSTRYTSFDDASTSGTVVVRGQNDDSGSPRTPRSRLGLQERSSSASEDSISNLAEAKLALEAGFRRGNARERLGNGKVNKRREQATDNSDYLRNSRDHSDKQRPVMRSQQVSDDEEDDSKLASLSASLSLLLLPSLKEAVGGDDSKGTIGHRVSRSLVKMEREKPGSSEAFIAKLIEQLGSTKEVSVKEVQDMAIRVFAKTMNNDAENKRKQASKEFSSNANFSPLARFLFSRWLGQTSRDLNQS
Protein: CUB domain-containing protein (LEV-10B) (G5EER3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHLIYLFLLSIFVSKADGNSRKTIFQCDQHFDESQPEGVIEFPSLPKQLALSHGVNNSKPEQQYNLQCVYTFVAGSRQRVRLEFDHFLLSGSSENCDIEYVDIYSEVESVDEDILSSALGGRYCGTVAPHVRISLRRVMKLVLHSRSTNHEDNHGFRAKYSFIPEDKFIAGEPVGGKKCSFIIDSSDRKIGTLYSPTYPGTYPHNMHCSYLMKAGRGERIRLFFTDFDIFFGGEHCPYDSVTIFDGPTPASPIIRKVCGLQQRMEVYSMGNSLLIHFNTTHPAKSDPRGFIMDYEFSTRFVNIDKLLNKQRGVTHIRGTECDVRVESNRETFHTISSPNYPEVYPANTTCTYIIHGLQGEQNLEKVILTFDSIAVLSFDTSPATAPPSADIDDIACPSAWVGIAIGEGNMKAVMSSTDDSTFDVTLCERIPPNSPLLGPYISEGPRMVMQFGSTETRDDNISPIGFKATIEFKTDFGVTGESLGTSNECKFRFTSSTGFFNSPRYPANYPLDTNCTYYIVGQPGKEILLHFEQFALSGNTDNNCNDYLDVYDVFVKNGKEELRRKERYCADTFPGPSVSAFGSHEMRVVFTSGSSGTANGFKALFEIRTARKEDVPRGEAHIRRGAYRCGSVINSTSEKPNGLIISPNYPVKYNKDVHCDWQINVKEGYQVLLKMEAIDVEGEMTSNGASCQKAVIRVDGGPRSEYCGTKREFFEAYLSPSNSVRISFLTAPDKVNGLKGFNLSWTEVKNLSGKDENVCKSDSLYLCTYSKLCIDAKLRCNGLDNCGYGVQDDTDEQHCQNYSPRTFYTAKFMATSSSATVALTILIIVMLVLPAILCAH
Protein: Macrophage galactose N-acetyl-galactosamine specific lectin 2 (Macrophage galactose-type C-type lectin 2) (Q8JZN1)
Organism: Mus musculus (Mouse)
Interaction partners:
- Resistin-like alpha
Sequence:
MTMRYENFQNLEREEKNQEMRNGDKKGGMESPKFALIPSQSFLWRILSWTHLLLFSLGLSLLLLVVISVIGSQNSQLRRDLGTLRAILDNTTSKIKAEFQSLDSRADNFEKGISSLKVDVEDHRQELQAGRDLSQKVTSLESTLEKREQALKTDLSDLTDHVQQLETDLKALTCQLANLKNNGSEVACCPLHWTEHEGSCYWFSESEKSWPEADKYCRLENSHLVVVNSLEEQNFLQNRLANVLSWMGLTDQNGPWRWVDGTDFDKGFKNWRPLQPDNWHGHMLGGGEDCAHFSYDGRWNDDVCQRHYHWICETELGKASSAHSPQLIASVP
Protein: Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) (Q9UN79)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3'. Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Cytoplasm {ECO:0000269|PubMed:10871192}.
Interaction partners:
- Centrosomal protein of 85 kDa
- Transcription factor SOX-5
- Transcription factor 7
Sequence:
MSMRSPISAQLALDGVGTMVNCTIKSEEKKEPCHEAPQGSATAAEPQPGDPARASQDSADPQAPAQGNFRGSWDCSSPEGNGSPEPKRPGVSEAASGSQEKLDFNRNLKEVVPAIEKLLSSDWKERFLGRNSMEAKDVKGTQESLAEKELQLLVMIHQLSTLRDQLLTAHSEQKNMAAMLFEKQQQQMELARQQQEQIAKQQQQLIQQQHKINLLQQQIQQVNMPYVMIPAFPPSHQPLPVTPDSQLALPIQPIPCKPVEYPLQLLHSPPAPVVKRPGAMATHHPLQEPSQPLNLTAKPKAPELPNTSSSPSLKMSSCVPRPPSHGGPTRDLQSSPPSLPLGFLGEGDAVTKAIQDARQLLHSHSGALDGSPNTPFRKDLISLDSSPAKERLEDGCVHPLEEAMLSCDMDGSRHFPESRNSSHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPYYEEQARLSRQHLEKYPDYKYKPRPKRTCIVEGKRLRVGEYKALMRTRRQDARQSYVIPPQAGQVQMSSSDVLYPRAAGMPLAQPLVEHYVPRSLDPNMPVIVNTCSLREEGEGTDDRHSVADGEMYRYSEDEDSEGEEKSDGELVVLTD
Protein: Frizzled-9 (Fz-9) (hFz9) (FzE6) (CD antigen CD349) (O00144)
Organism: Homo sapiens (Human)
Function: Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process. During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9R216}; Multi-pass membrane protein {ECO:0000255}. Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. {ECO:0000250|UniProtKB:Q8K4C8}.
Interaction partners:
- Protein Wnt-5a
- Protein Wnt-11
- Protein Wnt-7a
- Proto-oncogene Wnt-1
- Protein Wnt-2
- Protein Wnt-4
- Tyrosine-protein kinase RYK
- Protein Wnt-5b
- Protein Wnt-7b
- Protein Wnt-3a
Sequence:
MAVAPLRGALLLWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKIAAGRARAKACRAPGSYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL
Protein: peptidylprolyl isomerase (EC 5.2.1.8) (A0A060WZU7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein RACK1
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
Sequence:
MGVEIETITPGDGRTFPKKGQTCVVHYVGSLTDGRKFDSSRDSDKPFRFKIGKQEVIRGWDEGVVQMSVGQRARLTCSPDFAYGAKGHPGIIPPNATLLFDVELLSIE
Protein: Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) (P9WFU5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01228}.
Interaction partners:
- Leucine--tRNA ligase
- Glutamate--tRNA ligase
- Proline--tRNA ligase
- Isoleucine--tRNA ligase
- Uncharacterized metal-dependent hydrolase TatD
- Arginine--tRNA ligase
- GMP synthase
- Threonine--tRNA ligase
- Methionine synthase
- Methionyl-tRNA formyltransferase
Sequence:
MKPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDRYDVRFLTGTDEHGLKVAQAAAAAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHEASKELWRRMSAAGDIYLDNYSGWYSVRDERFFVESETQLVDGTRLTVETGTPVTWTEEQTYFFRLSAYTDKLLAHYHANPDFIAPETRRNEVISFVSGGLDDLSISRTSFDWGVQVPEHPDHVMYVWVDALTNYLTGAGFPDTDSELFRRYWPADLHMIGKDIIRFHAVYWPAFLMSAGIELPRRIFAHGFLHNRGEKMSKSVGNIVDPVALAEALGVDQVRYFLLREVPFGQDGSYSDEAIVTRINTDLANELGNLAQRSLSMVAKNLDGRVPNPGEFADADAALLATADGLLERVRGHFDAQAMHLALEAIWLMLGDANKYFSVQQPWVLRKSESEADQARFRTTLYVTCEVVRIAALLIQPVMPESAGKILDLLGQAPNQRSFAAVGVRLTPGTALPPPTGVFPRYQPPQPPEGK
Protein: Small ribosomal subunit protein uS11m (28S ribosomal protein S11, mitochondrial) (MRP-S11) (S11mt) (P82911)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279123, ECO:0000269|PubMed:24799711}.
Interaction partners:
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein bS6m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS12m
Sequence:
MQVLRNSGSWLLRSWAWPPTTRVVAGVPAPTIHMSAQQMQDAAAKEEVEKAETPAPAPSRSSFSIYPPIPGQESSLRWAGKKFEEIPIAHIKASYNNTQIHVVSAAHQPLARASCGTEGFRNAKKGTGIAAQTAGIAAAAKATGKGVTHVRVVVKGLGPGRLSAIKGLTMGGLEVISITDNTPIPHNGCRPRKARRL
Protein: Cta2p (A0A1D8PC38)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Cta24p
- Tlo1p
- Tlo9p
- Cta26p
- Tlo13p
Sequence:
MPENLQTRLHNSLDEILKSSGYIFEVIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKEEAARKKREEEAKKKEEEAKKKAEEAKKKEEEAKKAEEAKKAEEAKKVEEAAKKAEEAKKAEEEARKKAETAPQKFDNFDDFIGFDINDNTNDEDMLSNMDYEDLKLDDKVPATTDNNLDMNNILENDESILDGLNMTLLDNGDHVNEEFDVDSFLNQFGN
Protein: Cytochrome c oxidase subunit 13, mitochondrial (Cytochrome c oxidase polypeptide VIa) (O74471)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P32799}; Single-pass membrane protein {ECO:0000250|UniProtKB:P32799}.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase polypeptide 5, mitochondrial
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome c oxidase subunit 12, mitochondrial
- Cytochrome b-c1 complex subunit 7
- Cytochrome b-c1 complex subunit 9
Sequence:
MSMMNRNIGFLSRTLKTSVPKRAGLLSFRAYSNEAKVNWLEEVQAEEEHAKRSSEFWKKVTYYIGGPALILASANAYYIYCKHQEHAKHVEDTDPGYSFENLRFKKYPWGDGSKTLFWNDKVNHLKKDDE
Protein: Proteasome subunit beta type-11 (EC 3.4.25.1) (Proteasome subunit beta-5t) (Q8BG41)
Organism: Mus musculus (Mouse)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells.
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-10
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-2
- Proteasome subunit beta type-4
- Proteasome subunit beta type-3
- Proteasome subunit beta type-9
- Proteasome subunit alpha type-4
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-8
Sequence:
MALQDVCKWQTPDTPRPSIHLPQAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASRKVIPVHQRLLGTTSGTSADCATWYRVLRRELRLRELREGQLPSVAGTAKLLAAMMSCYRGLDLCVATALCGWDHSGPALFYVYSDGTCLQGDIFSVGSGSPYAYGVLDRGYHYDMTIQEAYTLARCAVAHATHRDAYSGGSVDLFHVRESGWEYVSRSDACVLYRELQKARSLEQELEAKACGIYPEPATPQGARECKELFVEQEEVTPEDCAIIMKTETM
Protein: 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B) (X5D7I5)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU368114}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU368114}.
Interaction partners:
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS