wanglab/gogpt-training-data huggingface dataset:
Protein: Circadian locomoter output cycles protein kaput-like Protein (Methoprene-tolerant) (A6MUT7)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDSGDCETEEDSAPEACVSPEGSLLPSNSREMRNRAEKMRRDKLNSYIGELATLVPMVARSAKRMDKTSILRLAATHLRIYQTLLSGKNHPHIQLPKHVDQYLLEQLVCEQLGGFLLILTPNGKIVFVSHTVEHLLGHLQTDLMGQSIFNITSPDDHDRLRMYINTESVLDGDWKKCFNIRLKRAGPRTESAVYEPVRIMGVHRPGFDNDCNKNTSTSKEIALNNDVLLFFVKVFRPEPLCERLFEASREEYVTRHLIDGRIIGCDQRISFIAGYMTEEVSGLSAFKFMHREDVRWVMIALRQMYDRGESKGSSCYRLLSRNGQFIYLRTFGFLEIDDQGTVESFVCVNTLVSEQEGLQLINEMKKRYSALINSQSCPITSSGSTDSSSQSVEDPQQVEAAIVHLIANLPSPGSDQRSTPSPRVYGNVNENQDCSTPTENSPTKPYYKLKTANNKRPPSTELGTNIYTSSKRQRTSPQLSPMSSLPPYPNRTQITEVTQQTEPSIYQHDQLLRNKV
Protein: ETS proto-oncogene 2, transcription factor (D4AAH4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004019}.
Interaction partners:
- Protein C-ets-1
- Mitogen-activated protein kinase 3
- DNA-binding protein inhibitor ID-1
- Mitogen-activated protein kinase 1
- Serum response factor
- Cyclin-dependent kinase 10
- Cellular tumor antigen p53
- Histone lysine acetyltransferase CREBBP
- Runt-related transcription factor 2
- Runt-related transcription factor 1
Sequence:
MDQVAPVANSFRGTLKRQPAFDTFDGSLFAVLPSLSEEQTLQEVPTGLDSVSHDSATCELPLLTPCSKAVMSQALKATFSGFHKEQRRLGIPKNPWLWNEQQVCQWLHWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEENSHLNAVPHWINSNTLGFGVEQAPYGMQAPSYLKDGLLDGMCPPSATPAALGSEQELQMLPKSRLNTVSVNYCSISQDFPGGNLNLLNSSSGKPKEHDSPENGGDSFESSDSLLRSWNSQSSLLDVQRVPSFESFEEDCSQSLCLSKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED
Protein: USG-1 protein (P08390)
Organism: Escherichia coli (strain K12)
Interaction partners:
- tRNA pseudouridine synthase A
- Bifunctional aspartokinase/homoserine dehydrogenase 2
- Bifunctional aspartokinase/homoserine dehydrogenase 1
- Protein DedA
- Phosphoglycerate kinase
Sequence:
MSEGWNIAVLGATGAVGEALLETLAERQFPVGEIYALARNESAGEQLRFGGKTITVQDAAEFDWTQAQLAFFVAGKEATAAWVEEATNSGCLVIDSSGLFALEPDVPLVVPEVNPFVLTDYRNRNVIAVPDSLTSQLLAALKPLIDQGGLSRISVTSLISASAQGKKAVDALAGQSAKLLNGIPIDEEDFFGRQLAFNMLPLLPDSEGSVREERRIVDEVRKILQDEGLMISASVVQAPVFYGHAQMVNFEALRPLAAEEARDAFVQGEDIVLSEENEFPTQVGDASGTPHLSVGCVRNDYGMPEQVQFWSVADNVRFGGALMAVKIAEKLVQEYLY
Protein: Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) (P03114)
Organism: Human papillomavirus type 16
Function: ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins. During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity. Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer. Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori. Subsequently, two hexamers will be created. The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
Subcellular location: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04000}.
Interaction partners:
Sequence:
MADPAGTNGEEGTGCNGWFYVEAVVEKKTGDAISDDENENDSDTGEDLVDFIVNDNDYLTQAETETAHALFTAQEAKQHRDAVQVLKRKYLVSPLSDISGCVDNNISPRLKAICIEKQSRAAKRRLFESEDSGYGNTEVETQQMLQVEGRHETETPCSQYSGGSGGGCSQYSSGSGGEGVSERHTICQTPLTNILNVLKTSNAKAAMLAKFKELYGVSFSELVRPFKSNKSTCCDWCIAAFGLTPSIADSIKTLLQQYCLYLHIQSLACSWGMVVLLLVRYKCGKNRETIEKLLSKLLCVSPMCMMIEPPKLRSTAAALYWYKTGISNISEVYGDTPEWIQRQTVLQHSFNDCTFELSQMVQWAYDNDIVDDSEIAYKYAQLADTNSNASAFLKSNSQAKIVKDCATMCRHYKRAEKKQMSMSQWIKYRCDRVDDGGDWKQIVMFLRYQGVEFMSFLTALKRFLQGIPKKNCILLYGAANTGKSLFGMSLMKFLQGSVICFVNSKSHFWLQPLADAKIGMLDDATVPCWNYIDDNLRNALDGNLVSMDVKHRPLVQLKCPPLLITSNINAGTDSRWPYLHNRLVVFTFPNEFPFDENGNPVYELNDKNWKSFFSRTWSRLSLHEDEDKENDGDSLPTFKCVSGQNTNTL
Protein: Dynein assembly factor with WD repeat domains 1 (Outer row dynein assembly protein 16) (Q3Y8L7)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Functions as a cargo-specific adapter between intraflagellar transport (IFT) particles and outer row dynein. Required for efficient dynein-mediated transport into the flagellar compartment.
Subcellular location: Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000269|PubMed:18852297}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:18852297}. Note=Expression is concentrated at the flagellum basal body but is also detected along the length of the flagellum. {ECO:0000269|PubMed:18852297}.
Interaction partners:
Sequence:
MAAKLRKFLLRYYPPGIILQYERDGVMKQKPIDLLDLTPDVDVEVLLSQIIRQEPLISENRRPALRQLIHRLIDKMLEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALTASSQPAGPGGAGGGLARPTTAFSYND
Protein: Phloroglucinol synthase (EC 2.3.1.253) (Type III polyketide synthase PhlD) (Q4K418)
Organism: Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Function: Type III polyketide synthase that catalyzes the synthesis of phloroglucinol from three molecules of malonyl-CoA. In addition to its ability to produce phloroglucinol from malonyl-CoA, it exhibits broad substrate specificity, accepting C4-C12 aliphatic acyl-CoAs and phenylacetyl-CoA as the starters to form C6-polyoxoalkylated alpha-pyrones from sequential condensation with malonyl-CoA.
Interaction partners:
- Polyketide synthase PltB
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit omega
- Putative permease PhlE
- 2,4-diacetylphloroglucinol biosynthesis protein PhlC
- DNA-directed RNA polymerase subunit alpha
- 2,4-diacetylphloroglucinol biosynthesis protein PhlB
- ATP synthase subunit c
- 2,4-diacetylphloroglucinol biosynthesis protein PhlA
Sequence:
MSTLCLPHVMFPQHKITQQQMVDHLENLHADHPRMALAKRMIANTEVNERHLVLPIDELAVHTGFTHRSIVYEREARQMSSAAARQAIENAGLQISDIRMVIVTSCTGFMMPSLTAHLINDLALPTSTVQLPIAQLGCVAGAAAINRANDFARLDARNHVLIVSLEFSSLCYQPDDTKLHAFISAALFGDAVSACVLRADDQAGGFKIKKTESYFLPKSEHYIKYDVKDTGFHFTLDKAVMNSIKDVAPVMERLNYESFEQNCAHNDFFIFHTGGRKILDELVMHLDLASNRVSQSRSSLSEAGNIASVVVFDVLKRQFDSNLNRGDIGLLAAFGPGFTAEMAVGEWTA
Protein: Xyloglucan endotransglucosylase/hydrolase protein 31 (At-XTH31) (AtXTR8) (XTH-31) (EC 2.4.1.207) (EC 3.2.1.151) (P93046)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues. Involved in the accumulation of hemicelluloses. Has a high XEH activity and only a slight XET activity in vitro, but the main in planta activity seems to be XET, thus controlling aluminum sensitivity. Acceptor preferences are XXXGol = XXFGol > XXLGol > XLLGol = XLFGol.
Subcellular location: Secreted, cell wall {ECO:0000305}. Secreted, extracellular space, apoplast {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:23204407}.
Interaction partners:
- Molybdate-anion transporter
- Alpha/beta-Hydrolases superfamily protein
Sequence:
MALSLIFLALLVLCPSSGHSQRSPSPGYYPSSRVPTSPFDREFRTLWGSQHQRREQDVVTLWLDKSTGSGFKSLRPYRSGYFGASIKLQPGFTAGVDTSLYLSNNQEHPGDHDEVDIEFLGTTPGKPYSLQTNVFVRGSGDRNVIGREMKFTLWFDPTQDFHHYAILWNPNQIVFFVDDVPIRTYNRKNEAIFPTRPMWVYGSIWDASDWATENGRIKADYRYQPFVAKYKNFKLAGCTADSSSSCRPPSPAPMRNRGLSRQQMAALTWAQRNFLVYNYCHDPKRDHTQTPEC
Protein: Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3) (O70566)
Organism: Mus musculus (Mouse)
Function: May be involved in oogenesis.
Interaction partners:
- Profilin-4
- Profilin-3
- Profilin-2
- Profilin-1
- Transforming protein RhoA
- Protein diaphanous homolog 1
- RIKEN cDNA 4930544G11 gene
- Rho-related GTP-binding protein RhoD
Sequence:
MEELGAAASGAGGGGGGGEEHGGGRSNKRGAGNRAANEEETRNKPKLRDRITSFRKSATKREKPVIQHSIDYQTAVVEIPPALIVHDDRSLILSEKEVLDLFEKMMEDMNLNEEKKAPLRKKDFSIKREMVVQYISATSKSIVGSKVLGGLKNSKHEFTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSHPVSWVNNFGYEGLGVLLDVLEKLLDKKQQENIDKKNQYKVIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQQNMMTEIVKILSAICIVGEENILDKLLGGITAAAELNNRERFSPIVEGLENNEALHLQVACMQFINALVTSPYDLDFRIHLRNEFLRCGLKAMLPTLKEIENEGLDIQLRVFEENKEDDLSELSHRLNDIRAEMDDINEVYHLLYNMLKDTAAEPYLLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRIDFDFTHLLDACVNKAKVEENEQKAMEFSKKFDEEFTARQEAQAELQKRDEKIKELETEIQQLRGQGVPSAIPGPPPPPPLPGAGPCPPPPPPPPPPPPLPGVVPPPPPPLPGMPGIPPPPPPPLSGVPPPPPPPGGVFPLLSGPIELPYGMKQKKLYKPDIPMKRINWSKIEPKELSENCVWLKLKEEKYENADLFAKLALTFPSQMKGQRNTEAAEENRSGPPKKKVKELRILDTKTAQNLSIFLGSYRMPYEEIKNIILEVNEEMLSEALIQNLVKYLPDQNALRELAQLKSEYDDLCEPEQFGVVMSTVKMLRPRLTSILFKLTFEEHVNNIKPSIIAVTLACEELKKSESFKRLLELILLVGNYMNSGSRNAQSLGFKINFLCKIKDTKSADQKSTLLHFLAEICDEKYRDILKFPDELEHVESAGKVSAQILKSNLVAMEQSILHLEKNIKNFPPAESHHDKFVEKMMSFTQNAREQYDKLSTMHSNMLKLYESLGEYFIFDPNTVNMEEFFGDLNTFRTLFLEALKENHKRKEMEEKSRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPDNRRPPLERSRSRHNGAMSSK
Protein: Protein YdaW (P76066)
Organism: Escherichia coli (strain K12)
Interaction partners:
Sequence:
METVFDALKAMGKATSIELAARLDISREEVLNELWELKKAGFVDKSAYTWRVADNNVQQEQPAQAELPEEITTATVAKISECDLTATIEQRGPQTADELATLFGTTSRKVASTLAMAISKGRLIRVNQGGKFRYCIPGDNLPAEPKAASVSPLWLSASSSACHGVLIITVITPSPTKNSATKMPEN
Protein: Histone deacetylase (EC 3.5.1.98) (A0A0R4IAH0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037911}.
Interaction partners:
Sequence:
MTSHSRPDGLPSKEQPLELLKPSGVNHIPPVDVSVALPLQVPPSAIPMDLRVDHQFALAPTDPAQREHQLQQELLALKQKQQIQRQLLIEEFQRQHEQLSRQHEAQLQEHVKHQQDLLALKHQQELLEHQRKLERHRQEQEMEKQQREQKLQLLKNKERGQESAVASTEVKMRLQEFVLNKKKALAQRSLNHCLPSDPRYWYGKTQHSSLDQSSPPQTGISTYNHPVLGMYDPKDDFPLRKTASEPNLKLRSRLKQKVSERRSSPLLRRKDGPITTAKKRSLDMAESACSSAPGSGPSSPNNSSNNITNENGIAGSISNSAVEPSLAHRLTGREGPVSQLSLYTSPSLPNITLGLPATGPSSVASGQQDGDRMAVPGLQPGIPITTPFMPGAHLPSYLAASSLERESGSAHNTLLQHMVLLEQSAAQNSLVAGLSGVPLQSHSIHKLRQHRPLGRTQSAPLPQNSQALQQLVVQQQHQQFLEKHKQQFQQQQLHISKMMVKPSEPNRQHESHPEETEEELREHQGLGDPADPLPHGVTIKQEPPDEQDEDFQQRERQAEEELLFRQQALLLEQQRIHQLRNYQASMEAAGLSVSFPVHRPLSRAQSSPASATFPIVVQEPPAKPRFTTGLVYDTLMQKHQCMCGNSNIHPEHAGRIQSIWSRLQETGLRGQCECIRGRKATLEELQTVHSEAHVLLYGTNPLRQKLDSSVTPMFVRLPCGGIGVDSDTIWNEVHSSSAARLAVGSVVDLVFKVASGELRNGFAVVRPPGHHAEESTPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYSDPNVLYLSLHRYDDGNFFPGSGAPDEVGIGPGVGFNVNMAFTGGLEPPMGDADYLAAFRSVVMPIANEFSPDVVLVSSGFDAVEGHPPPLGGYKLTAKCFGYLTKQLMGLAGGRLVLALEGGHDLTAICDASEACVSALLGNELDPIPEDILQQRPNANAIQSMEKVLEVQSKYWRSLQRSVSTLGYSLREAQRCENEEAETVTAMASLSVANKHMGKRPEEEPMEEEPPL
Protein: F-box protein At3g13820 (Q9LRW6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g06180
Sequence:
MTTMSNLPAEVLEEILSRTPVTSLRTMRSTCKKWNNLSKKKIIPEAARKQQGLMLIKKKICSLSFSLHEIHKDDYVVPCINQVDIPRNIEVEKIFHCDGILLCVIEDNCSLLVWNPYLGQTRRIEVSSDADMNDRYALGYDNNNSSHKILRIKKDFKNSDGLGYEIYRFASNSWSLLDEEVMKPEWDVWSVQRSSVSLKGNTYFLLQGNDYDDQEDEEEEDDEEYEDDDDVLPKDNFLLCFDYTTERFGPRLLLPFNPHVEETVALSCIGEERLVMLYQSFKTYKGIEIWVTDKIDPKAVSWSKFLKVDITPLTGFPVDFYADSFVIDEEKKVAAVFDIHCSYQKAHIIGEDGYLKCVNMGRASDVGNGQPLVFSSYVPSLVKVPVKQPKGKRKGRSSETKSNKNKKGRKIKIIG
Protein: Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) (P42566)
Organism: Homo sapiens (Human)
Function: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. {ECO:0000269|PubMed:16159959}.; SUBCELLULAR LOCATION: [Isoform 2]: Early endosome membrane {ECO:0000269|PubMed:18362181}; Peripheral membrane protein {ECO:0000269|PubMed:18362181}; Cytoplasmic side {ECO:0000269|PubMed:18362181}. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes.
Interaction partners:
- Epsin-2
- F-BAR domain only protein 1
- Stonin-2
- Epsin-3
- Epsin-1
- Intersectin-2
- Intersectin-1
- F-BAR domain only protein 2
- Epidermal growth factor receptor
- SH3-containing GRB2-like protein 3-interacting protein 1
Sequence:
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
Protein: Rap1 GTPase-activating protein (A0A8I5ZN32)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
ASGDDRSQACFTRPSFSSRRSDGQKHSFPQTLNVLLVDSVPSHPASPYPKVTSLLLQGSRMDEQRCSFPPPLKVLGREGPFPLILLPQFGGYWIEGTNHEISSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVGKLEPSRAPGCEERGLLRGAAYLLERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLLIPGKSASRFGRRGSALGIGAVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGMESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDAVKSGDPACPEIKIQLETSEQHTPQMV
Protein: Microtubule-associated protein 4 (MAP-4) (P27546)
Organism: Mus musculus (Mouse)
Function: Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P27816}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:P27816}. Note=Recruitment to microtubule is inhibited by microtubules polyglutamylation. {ECO:0000250|UniProtKB:P27816}.
Interaction partners:
Sequence:
MADLSLVDALTEPPPEIEGEIKRDFMAALEAEPYDDIVGETVEKTEFIPLLDGDEKTGNSESKKKPCLDTSQVEGIPSSKPTLLANGDHGMEGNNTAGSPTDFLEERVDYPDYQSSQNWPEDASFCFQPQQVLDTDQAEPFNEHRDDGLADLLFVSSGPTNASAFTERDNPSEDSYGMLPCDSFASTAVVSQEWSVGAPNSPCSESCVSPEVTIETLQPATELSKAAEVESVKEQLPAKALETMAEQTTDVVHSPSTDTTPGPDTEAALAKDIEEITKPDVILANVTQPSTESDMFLAQDMELLTGTEAAHANNIILPTEPDESSTKDVAPPMEEEIVPGNDTTSPKETETTLPIKMDLAPPEDVLLTKETELAPAKGMVSLSEIEEALAKNDESSAEIPVAQETVVSETEVVLATEVVLPSDPITTLTKDVTLPLEAERPLVTDMTPSLETEMTLGKETAPPTETNLGMAKDMSPLPESEVTLGKDVVILPETKVAEFNNVTPLSEEEVTSVKDMSPSAETEAPLAKNADLHSGTELIVDNSMAPASDLALPLETKVATVPIKDKGTVQTEEKPREDSQLASMQHKGQSTVPPCTASPEPVKAAEQMSTLPIDAPSPLENLEQKETPGSQPSEPCSGVSRQEEAKAAVGVTGNDITTPPNKEPPPSPEKKAKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTSGGLNKKPMSLASGSVPAAPHKRPAAATATARPSTLPARDVKPKPITEAKVAEKRTSPSKPSSAPALKPGPKTTPTVSKATSPSTLVSTGPSSRSPATTLPKRPTSIKTEGKPADVKRMTAKSASADLSRSKTTSASSVKRNTTPTGAAPPAGMTSTRVKPMSAPSRSSGALSVDKKPTSTKPSSSAPRVSRLATTVSAPDLKSVRSKVGSTENIKHQPGGGRAKVEKKTEAATTAGKPEPNAVTKAAGSIASAQKPPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEALPCPGPPAGEEPVIPEAAPDAGAPTSASGLSGHTTLSGGGDQREPQTLDSQIQETSI
Protein: ABC transporter B family member 11 (ABC transporter ABCB.11) (AtABCB11) (Multidrug resistance protein 8) (P-glycoprotein 11) (Q9FWX7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- ABC transporter G family member 29
Sequence:
MNGDGAREGDSVSHEPSTSKSPKEGEETKKEEKSEEKANTVPFYKLFAFADSSDVLLMICGSIGAIGNGMSLPFMTLLFGDLIDSFGKNQNNKDIVDVVSKVCLKFVYLGLGTLGAAFLQVACWMITGERQAARIRSTYLKTILRQDIGFFDVETNTGEVVGRMSGDTVLIQDAMGEKVGKFIQLVSTFVGGFVLAFIKGWLLTLVMLTSIPLLAMAGAAMALIVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKFITSAYKSSIQQGFSTGLGLGVMFFVFFSSYALAIWFGGKMILEKGYTGGAVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLEDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVISLIERFYDPKSGAVLIDGVNLKEFQLKWIRSKIGLVSQEPVLFSSSIMENIAYGKENATVEEIKAATELANAAKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMVNRTTVIVAHRLSTVRNADMIAVIHRGKMVEKGSHSELLKDSEGAYSQLIRLQEINKDVKTSELSSGSSFRNSNLKKSMEGTSSVGNSSRHHSLNVLGLTTGLDLGSHSQRAGQDETGTASQEPLPKVSLTRIAALNKPEIPVLLLGTVAAAINGAIFPLFGILISRVIEAFFKPAHELKRDSRFWAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEKAVHMEVAWFDEPQNSSGTMGARLSADATLIRALVGDALSLAVQNVASAASGLIIAFTASWELALIILVMLPLIGINGFVQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYKKQCEGPIKDGIKQGFISGLGFGFSFFILFCVYATSFYAGARLVEDGKTTFNNVFQVFFALTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVKGDIELRHLSFTYPARPDIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEKGTHETLIKIEGGVYASLVQLHMTASN
Protein: Endothelin-converting enzyme 2 (ECE-2) (EC 3.4.24.71) (P0DPD6)
Organism: Homo sapiens (Human)
Function: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:F1N476}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:F1N476}.
Interaction partners:
- Endothelin-1
- Endothelin-3
- Endothelin-1 receptor
- EEF1A lysine methyltransferase 4
- Endothelin-2
- Insulin-degrading enzyme
- Amyloid-beta precursor protein
- Endothelin receptor type B
Sequence:
MNVALQELGAGSNMVEYKRATLRDEDAPETPVEGGASPDAMEVGKGASPFSPGPSPGMTPGTPRSSGLFWRVTCPHLRSISGLCSRTMVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW
Protein: Interferon alpha-6 (IFN-alpha-6) (Interferon alpha-54) (Interferon alpha-K) (LeIF K) (P05013)
Organism: Homo sapiens (Human)
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular location: Secreted.
Interaction partners:
- Interferon alpha/beta receptor 1
- Interferon alpha-14
- Interferon alpha-5
- Interferon alpha-1/13
- Interferon gamma receptor 1
- Interleukin-2
- Interferon regulatory factor 3
- Interferon regulatory factor 7
- Interferon alpha/beta receptor 2
- Interferon alpha-21
Sequence:
MALPFALLMALVVLSCKSSCSLDCDLPQTHSLGHRRTMMLLAQMRRISLFSCLKDRHDFRFPQEEFDGNQFQKAEAISVLHEVIQQTFNLFSTKDSSVAWDERLLDKLYTELYQQLNDLEACVMQEVWVGGTPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSSSRNLQERLRRKE
Protein: HLA-DMB (A0A1V0E3P2)
Organism: Homo sapiens (Human)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004352}.
Interaction partners:
Sequence:
MITFLPLLLGLSLGCTGAGGFVAHVESTCLLDDAGTPKDFTYCISFNKDLLTCWDPEENKMAPCEFGVLNSLANVLSQHLNQKDTLMQRLRNGLQNCATHTQPFWGSLTNRTRPPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAHKTAQPNGDWTYQTLSHLALTPSYGDTYTCVVEHTGAPEPILRDWTPGLSPMQTLKVSVSAVTLGLGLIIFSLGVISWRRAGHSSYTPLPGSNYSEGWHIS
Protein: Serpin domain-containing protein (Q9D1E7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MILFPEADGKFTVEMYRQLRESDKNIFYSPISMITALGMLKLGAKGNTEIQIEKVLQCNETTEKTTEKSAHCDDEDNVHEQFQKLITQLNKSNDDYDLKAANSIYGAKGFPLLQTFLEDIKEYYHANVESLDFEHAAEESEKKINFSVKNETNGKIKDLFPSGSLSSSTKLVLVNAVYFKGRWNHKFDENNTIEEMFWLNKNTSIPVPMMKQRNKFMFSFLEDVQAQIVEIPYKGKELSMFVLRPMEIDGLKQLEKQLTAAKLLEWTRAENMHLTELYLWLPRFKVEEKYDLPVPLECMGMVNAFDPQKADFSGMSSTQGLVVSKVLHKSFVEVNEEGTEADPASGEEVILRLAQVADFRCDHPFLFFIIHSKTNSILFFGRISSP
Protein: Presilphiperfolan-8-beta-ol synthase (PSPS) (EC 4.2.3.74) (Botrydial synthesis protein 2) (Calcineurin-dependent protein 15) (Sesquiterpene cyclase BOT2) (Sesquiterpene synthase BOT2) (Q6WP50)
Organism: Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Function: Presilphiperfolan-8-beta-ol synthase; part of the gene cluster that mediates the biosynthesis of botrydial. Botrydial is necessary for colonization of plant tissue by the T4 strain. It is a strain-dependent virulence factor since highly aggressive strains like SAS56 or B05 still retain substantial virulence when botrydial synthesis is impaired, since they produce also botcinic acid. The first step of botrydial biosynthesis is performed by the sesquiterpene synthase BOT2 which catalyzes the cyclization of farnesyl diphosphate (FPP) to presilphiperfolan-8-beta-ol (PSP). The cytochrome P450 monooxygenase BOT4 then catalyzes the hydroxylation at C-4 to give a probotryane intermediate. Acetylation of the hydroxyl at C-4 is carried out by the acetyltransferase BOT5, followed by the combined action of the P450 monooxygenases BOT3 and BOT1, to yield finally the glycol, via the regio- and stereospecific hydroxylations at C-10 and C-15 of the probotryane intermediates, respectively. The cleavage of the C10-C15 bond of probotryane skeleton is an intriguing and chemically important reaction, which could be mediated by some of the monooxygenases or by a combination of them. It is possible that either BOT3 or BOT1 would oxidize either the 10- or the 15-hydroxy group to the hydroperoxide derivative, which would then undergo heterolytic fragmentation to give the dialdehyde botrydial. Finally, the dehydrogenase BOT7 might be involved in the conversion of botrydial to dihydrobotrydial.
Interaction partners:
Sequence:
MAIPALEPQLHDADTSSNNMSSNSTDSGYDTNSTTPLEKSEKPNTQELKQQQLDPKRPPFVRVPDLFGSIMSTKPVVNPNYFAAKARGDRWIARVMNFNKAVAARNSKVDLCFLASMWAPDAPEDRLVMMLDWNHWVFLFDDQFDEGHLKEDPAAAAEEVKQTIAIMGGNAPRYTAESNPIRYVFQQCWDRLKAVSSQEMQQRWIDQHKRYFDQLLVQVDQQVGGENFTRDVEAYMDLRRGTIGVYPAISLSEYGAGVNVPQHVYDHPSLQECMKVSADLVTLVNDVLSYRKDLELGVDHNLMSLLMQRDNLSAQQAVDVIGDMVNECYRRWYLALAELPSYGEKIDYNVMKFVEICRAVAQGNLYWSFQTGRYLGPEGHEVHETGIMYLPPAANLVVA