wanglab/gogpt-training-data huggingface dataset:
Protein: Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) (Q5DTX6)
Organism: Mus musculus (Mouse)
Subcellular location: Cell junction, adherens junction {ECO:0000269|PubMed:21884682}. Note=Colocalizes with CDH5/VE-Cadherin in endothelial cells but not in epithelial cells. {ECO:0000269|PubMed:21884682}.
Interaction partners:
Sequence:
MYSVEDLLISHGYKPARDAAAPCEDKSERCRSTRTGPRAGQGLLNGYKDGATAHTHSRTSLGTGHVSNSENRISRPRGHREHQSTSRTPEARFLNQPSLAWSSQPQSGRDDIYWSRGRQEGSGSLCPRDWKELESRGMAQAYSLPVHVRENLWEVAGRTEHVMKNAIWEEELRMQDMSLESWKKPRELGRQASDGDGRKRPQEKFEGLYPFVHGEHTSQNRKKSQSLPRALSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSFPSPSEPMRNLEKASSSGPFPRPKFGKPLKTPCYSSHSQPRGEGGFQDHQHRDPRGSYPTRSKDPSHELGMLDPGLEPPVYVPPPSYRSPPQHIPNPYLEDPVPRHVSSNQSQQQVPEKPETSCPLPSGSLAARDLYDAMPGSPPQGLPPQPYPIATHGGSIQYIPFDDPRIRHIKLAQPPEFYEEAKLDDTSYNPGLLTTQEPAIGKRQYDDAPSVPRGPTPSPVNEQSSAFVHSSPRWLQGQLPLGIGPGGFHGQTEHHVMGGLTTNVTDIKAEGHASSPQPQSEGTCKTYTKLRKFETGVQSKKSSKKKSNATIFCLVSIPVKSESLVLATDTNNNDFKLVADKTRGLCQGSALQEQSLLSMSSTDLELQALMGSMAWRRTSPRQGLRESEDGQIDDPRILHLIKPKELQASSPWPGHQYRDQQTQTSFHEDSKSSQLLPATKPGEASNVAPTPTCPDTTASEVCLHTALAFSDQNQKPSVPHLQGQTSLSPSRNSAFSRTSSAINQASMSKGTSDQLPGANPVPKPEVVKGESTTGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESHGGSGSEDSEAEQPEDCADSRTKSWALQGTRTAQQPAGLALENVASPDRRLNDSQSWNEEPKPGHSSVHPQSLGPSQEEGSRGVPVQWADGSLTAEQKSQEDLNGMCERDFSPRPVSRIAPIDTKAAPLYCLSEPRGSQELTKFGDAVGSVQLGRETPTQVGNGGDTEVLPCVLLPLADKYRGHSTPDFRSLELTLGQEQNAYKLECLDLENTVEVLPSESLQERAERILGIEVAVESLLPSARRTEQSQLPEPDASACNPSSSREDSSHSLALPVGPKVATDAFYGRRKCGWTESPLFVGERAPQASICSDVDGFPTSQATSPEPGKKDEEAKAPFKSTLFHFMEKSTNVVGPEKRLRNPSKVVENLQEKLVSPPKKADSVHLIRMREVNSLSQMRCLSSKSADSVEEPDPLKVIKSSAWLSEGLTSLGGKDEAWQAGHLPSVSQNENGHPEVPRDKMSDQDLWCADSYDPSRVERV
Protein: HTH-type transcriptional activator RamA (LuxR-type transcriptional regulator) (Regulator of acetate metabolism A) (RAMA) (Q8NML3)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Function: RamA is a master regulator of acetate metabolism. It positively controls the expression of acnA, aceA, aceB, ack, pta and ramB genes in the presence of acetate. RamA is also a positive regulator of rpf2 gene expression during growth on glucose as the sole carbon source.
Interaction partners:
- CRP-like cAMP-activated global transcriptional regulator
- HTH-type transcriptional regulator RamB
- Diphtheria toxin repressor
- NYN domain-containing protein
- Isocitrate lyase
- Malate synthase G
Sequence:
MDTQRIKDDEDAIRSALTSLKTATGIPVTMFATVLQDNRLQITQWVGLRTPALQNLVIEPGVGVGGRVVATRRPVGVSDYTRANVISHEKDSAIQDEGLHSIVAVPVIVHREIRGVLYVGVHSAVRLGDTVIEEVTMTARTLEQNLAINSALRRNGVPDGRGSLKANRVMNGAEWEQVRSTHSKLRMLANRVTDEDLRRDLEELCDQMVTPVRIKQTTKLSARELDVLACVALGHTNVEAAEEMGIGAETVKSYLRSVMRKLGAHTRYEAVNAARRIGALP
Protein: UPF0495 protein YPR010C-A (A5Z2X5)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26928762}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome b-c1 complex subunit 1, mitochondrial
Sequence:
MRPAQLLLNTAKKTSGGYKIPVELTPLFLAVGVALCSGTYFTYKKLRTDETLRLTGNPELSSLDEVLAKDKD
Protein: Small ribosomal subunit protein uS2 (40S ribosomal protein SA) (P46769)
Organism: Caenorhabditis elegans
Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
Subcellular location: Cytoplasm.
Interaction partners:
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL18
Sequence:
MSGGAAHSALTEEDVMKLLATQAHLGSTNLNFQMQQYVYKRRFDGPNIINVKKTWEKLLLAARAIAAVENPADVVVVSARPYAQRALLKFAAHTGATAIFGRFSPGCLTNQIQKTFKEPRLLVISDPRIDHQAVTEASYVGVPVISFVNTESPLKLIDIGVPCNNKGERSIGLMWWMLAREILILRGKISRQTGFVLEGKEIMPDLYFYRDPTETEKEETGAHADVAEAQEYQQPTDIDFTTQGGKVDDWAAETATWTAETKTTEEWANAPTQSNW
Protein: Netrin-1 (O42140)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Unc-5 netrin receptor B.
- Neogenin
- Neogenin 1b
- Slit homolog 1a
- Slit homolog 1b
- Si:ch73-72b7.1.
- Draxin
- Unc-5 netrin receptor C.
- Cell adhesion molecule DSCAM
- Down syndrome cell adhesion molecule a.
Sequence:
MLRVSDALVTLVTLCCVLKGTVGGYGMSMFAAQTSPPDPCYDENGHPRRCIPDFVNAAFGKEVRASSTCGKTPSRYCVVTEKGDERHRNCHTCDASDPKKNHPPAYLTDLNNPHNLTCWQSDNYLQYPQNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIFKSMDYGKSWVPFQYYSTQCRKMYNKPSKATITKQNEQEAICTDSHTDMHPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIKVTFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHASRCVKDRDGNLVCECKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMSKPISHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCANGYQQSRSPIAPCIKIPIAPPTTTASSTEEPSDCESYCKASKGKLKINMKKYCKKDYAVQVHILKADKAGEWWKFTVNIISVYKQGESRIRRGDQFLWVRAKDVACKCPKIKSGKKYLLLGNDEDSPGQSGMVADKGSLVIQWRDTWARRLRKFQQREKKGKCKKA
Protein: Amyloid-beta-like protein (Q10651)
Organism: Caenorhabditis elegans
Function: Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg-laying. May play a role in neurotransmission.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Early endosome {ECO:0000269|PubMed:20862215}.
Interaction partners:
- Protein lin-10
- Contactin rig-6
- GYF domain-containing protein
- C2H2-type domain-containing protein
- CX domain-containing protein
- Serine protease svh-1
- Annexin
- Protein Fe65 homolog
- Nicastrin
- C2 domain-containing protein
Sequence:
MTVGKLMIGLLIPILVATVYAEGSPAGSKRHEKFIPMVAFSCGYRNQYMTEEGSWKTDDERYATCFSGKLDILKYCRKAYPSMNITNIVEYSHEVSISDWCREEGSPCKWTHSVRPYHCIDGEFHSEALQVPHDCQFSHVNSRDQCNDYQHWKDEAGKQCKTKKSKGNKDMIVRSFAVLEPCALDMFTGVEFVCCPNDQTNKTDVQKTKEDEDDDDDEDDAYEDDYSEESDEKDEEEPSSQDPYFKIANWTNEHDDFKKAEMRMDEKHRKKVDKVMKEWGDLETRYNEQKAKDPKGAEKFKSQMNARFQKTVSSLEEEHKRMRKEIEAVHEERVQAMLNEKKRDATHDYRQALATHVNKPNKHSVLQSLKAYIRAEEKDRMHTLNRYRHLLKADSKEAAAYKPTVIHRLRYIDLRINGTLAMLRDFPDLEKYVRPIAVTYWKDYRDEVSPDISVEDSELTPIIHDDEFSKNAKLDVKAPTTTAKPVKETDNAKVLPTEASDSEEEADEYYEDEDDEQVKKTPDMKKKVKVVDIKPKEIKVTIEEEKKAPKLVETSVQTDDEDDDEDSSSSTSSESDEDEDKNIKELRVDIEPIIDEPASFYRHDKLIQSPEVERSASSVFQPYVLASAMFITAICIIAFAITNARRRRAMRGFIEVDVYTPEERHVAGMQVNGYENPTYSFFDSKA
Protein: Peptidyl-prolyl cis-trans isomerase D, mitochondrial (PPIase D) (EC 5.2.1.8) (Cyclophilin D) (Rotamase D) (Q9UA41)
Organism: Dictyostelium discoideum (Social amoeba)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10575348}.
Interaction partners:
- Ran-specific GTPase-activating protein homolog
- Nuclear pore protein
- Uncharacterized protein
- Cysteine proteinase 4
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase qkgA
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase roco11
- 50S ribosomal protein L13
Sequence:
MTGIIRNKVFFQIKQGNTPLGRVVFELYNDIVPKTAENFRALCTGEKGIGKSGKPLHYKGSSFHRVIKNFMVQGGDFTHGTGIGGESIYGRTFNDENFLVKHKIGCLSMANAGKNTNGSQFFITTAETPHLNGGHTVFGEVVEGFDIVKKVENAETDRSDRPKAACVIEDCGQL
Protein: Ovocleidin-116 (OC-116) (F1NSM7)
Organism: Gallus gallus (Chicken)
Function: Major component of the eggshell matrix. May play an important role in the regulation of calcite growth during eggshell calcification. May also regulate the mineralization process in developing and growing bones.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10551857}. Note=Synthesized and secreted by the granular epithelial cells of the uterus and incorporated into the eggshell matrix. {ECO:0000269|PubMed:10551857}.
Interaction partners:
- Ovocalyxin-32
- Uncharacterized protein.
- Uncharacterized protein.
- Ovotransferrin
- Osteopontin
- Ovotransferrin
- Ovotransferrin
- Sclerostin
- Integrin-binding sialoprotein
Sequence:
MRATLFCLCLCLLGTVLPTPVSLPARARGNCPGQHQILLKGCNTKHGFYIFQYIYSHLMQKNQTQVKKEEGDHQGTIHGHWLGKVDGEAPGQGAGSSHVPEDKDSPKTHSHITPASKGEGRALRPGIGDSNSVYPTSTSVEGSGDMGSILLGEIINGEDGLPQSTHPGGPHGDGDGGNGVLVDGAVTAGRERASGSEGAGSEGGSHAPVPDQGQAGTMGTGDSAITSVTDSAITSVTKKEDVHVDTEGIDEFAYIPDVDAVTITRGQDGETHISPEDEVKIFIGRANIQVGENDSSVGSAGATSEANVIPTVVTVRPQGHPEESATMATLHHGDSVTSRPVGHPSVGNSGDGATEIHSGQELEAPSPWESTGGDATVTMAVGVQSGKGRSGQRALGKHSLPATMTTRGGRGTASSGLTTGDCSTAASTPSRKGSHVVSAGQGESGEVGTAGPERQRARVQQEVAPARGVVGGMVVPEGHRARVQQEVAPARGVVGGMVVPEGHRARTQPEVASAPSTVGKAAPERHRNRAQQEVAPVPSMVVETVAPERHRARVRPESARLGQAARPEVAPAPSTGGRIVAPGGHRARVWPGAAPAPGVVGVARPAPSKAYNGDKRVAIGKSTDVPRDPWVWGSAHPQAQHTRGSTVAGGFAHLHRGQRLGGLTEMEHSRQVEQVRHADRLRLHERAVYGLSGVGGPLQPPAVHTDPWSADSSQSSEGRWGSHSDSHEEDGEVRGYPYGRQSL
Protein: Hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) (P54839)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Hydroxymethylglutaryl-CoA synthase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA). ERG13 condenses acetyl-CoA with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA (HMG-CoA). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication.
Interaction partners:
- 3-ketoacyl-CoA thiolase, peroxisomal
- Acetyl-CoA acetyltransferase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
- Diphosphomevalonate decarboxylase
- Squalene epoxidase ERG1
- Isopentenyl-diphosphate delta-isomerase
- Squalene synthase ERG9
- Lanosterol 14-alpha demethylase CYP51
- Mevalonate kinase
Sequence:
MKLSTKLCWCGIKGRLRPQKQQQLHNTNLQMTELKKQKTAEQKTRPQNVGIKGIQIYIPTQCVNQSELEKFDGVSQGKYTIGLGQTNMSFVNDREDIYSMSLTVLSKLIKSYNIDTNKIGRLEVGTETLIDKSKSVKSVLMQLFGENTDVEGIDTLNACYGGTNALFNSLNWIESNAWDGRDAIVVCGDIAIYDKGAARPTGGAGTVAMWIGPDAPIVFDSVRASYMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDQVYKSYSKKAISKGLVSDPAGSDALNVLKYFDYNVFHVPTCKLVTKSYGRLLYNDFRANPQLFPEVDAELATRDYDESLTDKNIEKTFVNVAKPFHKERVAQSLIVPTNTGNMYTASVYAAFASLLNYVGSDDLQGKRVGLFSYGSGLAASLYSCKIVGDVQHIIKELDITNKLAKRITETPKDYEAAIELRENAHLKKNFKPQGSIEHLQSGVYYLTNIDDKFRRSYDVKK
Protein: FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3) (Q14802)
Organism: Homo sapiens (Human)
Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- FXYD domain-containing ion transport regulator 7
- FXYD domain-containing ion transport regulator 5
Sequence:
MQKVTLGLLVFLAGFPVLDANDLEDKNSPFYYDWHSLQVGGLICAGVLCAMGIIIVMSAKCKCKFGQKSGHHPGETPPLITPGSAQS
Protein: Exostoses (Multiple)-like 3 (Exostosin-like 3 (EC 2.4.1.223)) (Exostosin-like glycosyltransferase 3) (Q5U7D2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648}.
Interaction partners:
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
- Exostosin-like 2
- Adenosine 3'-phospho 5'-phosphosulfate transporter 1
- Hexosyltransferase.
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
- [heparan sulfate]-glucosamine N-sulfotransferase
- Xylosyltransferase II.
- Hexosyltransferase
- UDP-glucuronic acid decarboxylase 1
- Hexosyltransferase
Sequence:
MQRNGGIVGNGGQPWVLRRVRLTWLSFMLFFILVFFPLIAHYYLTTIDEAGGPDKRIFGPRPGGELCEAKHVQDLCRIRESVSEELLQLEAKRQELNGEIARLNLRIEACKRSIDSAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPVRLLPDKDDPGYPPPKSPQSCRLHSCFDYARCPLTSGFPVYVYDTGSYPWGEKLDPLVKQAFASSVKSSVYVTDNPNIACLYIALVGEIQESPSSPLASPSDLEKQLKALPYWRSDGHNHLLVHLSINSLTQNFLYNVSTGRAAVAQSTFFERQYREGFDLVVSPLVHALSEPNFLEVPPQVPVKRKYLFTFQGEKVESLRSSLLEAPPQSFEEEMEGDPPADYDDRIIGTLKAVQDSHLDQVLVEFTCKNQAKPSLPTEWALCGKREDRLEVLKVSTFALVISPGDGQLVASAGCSMRLFEALEVGAIPVVLGDHSKLPYHHLIRWSEAVIMVPKPRITELHFLLRSISDNDLLAMRRQGRFLWETYFSTSESIFNTILASVRTSIQIPAAPIREEPAQEIPHKAGKLAGTDANLADNGDLDLGPVEVEPPYASPRFLRNFTYTAADVYRTWNRAPGPFHLFPHTPLDPVLPSEAKFLGSGTGFRPIGGGSGGSGKEFQAALGGNVPREQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPKPPSDDLLWPDIGLPIVVVRTGKNSLNNRFLPWDAIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRFHAWDLNHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPRAIRDMVDEYINCEDIAMNFLVSHITRKPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLPHDKTKCFKFI
Protein: C3H1-type domain-containing protein (Q38C87)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPPADRNDIEEERVSRWCVTDEERPIPPDSYLSPNGALTVATNAVSPPPYPCSVQRVVHPEGPVHHFVDSDSPGCGYDDKFGAGDDEVKGGELYMWVLDPHSRKLRVPLSLMVPTHATANKGALPSLCLSFLEGHCRHEWCRQAHVPPHVLPMLRQQALNAPTCCRLHKDPHSTTELTDRFKFIRLVGNEGSYSSRGTNGEQSDLIPAERVALTVGLQLIIAQSAQAAKEKEEQSQNLGETNQGAANGAKVERKDVLDVPAKDVCRLHISRLCRYVEDCKNIHICREYDLQLPPPPNLVCLLNGITPSMTMINIGERSYSSTMLSLGDVTDEVFNIICDQQRRSVMNNTPAARMTPASQPYQHANQVVSCANPGVDAAINSASPLSLGDANLYTAPRGGTSPASCGMGDATPFAPASQRSLGQNGSPNLGAAAAGSSNVTRVLRIFDVRPKSAGEGGRERGSTHRGHNTNGNGSAGASPFLNGRGSESASRSRNGASVSYNNYTCPNSKNGSGNGCAAGAGVPPCGINGSDRNACSGSHRRGSRHLTGQSNNSGRGSAKRRQKA
Protein: Lysophosphatidic acid receptor 4 (A0A0N4STT7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MASLVLNETGMENCGIDDSFKYNLYGVVYSVAFVLGLATNCASLFVFCCRMKMRNETTLFMTNLALSDLVFVFTLPFKIFYNVNRHWPFGDTLCKISGGAFITNIYGSMLFLTCISVDRFLAIVYPFRSLSIRTRRNAGIVCATIWLLILGGGMSVTFFSSTNQSKTSTTCFEGFSKKTWKTYLSKITIFIEVMGFLIPLLINLACSSMVLRTLRQPATLCQIGTNKERVLRMIVVHLAIFIVCFVPYNTVLFVYAMVRTRALASCWVERLARTLYPITLCIATFNCFFDPVVYYFTSESFQKSLTTGKNQAMQEDGLQNECPLSNKEKTDVADLYTLTRNGKDQVGETQF
Protein: Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM (Protein FERTILIZATION-INDEPENDENT SEED 3) (Q9LT47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization. Probably also involved in floral repression mechanism established during early plant development. Regulates the anteroposterior organization of the endosperm. Interacts with the promoter and represses the transcription of genes such as PHE1, that are paternally active and maternally silenced.
Subcellular location: Nucleus {ECO:0000269|PubMed:11114524}. Note=Excluded from the nucleolus.
Interaction partners:
- Polycomb group protein EMBRYONIC FLOWER 2
- Histone-lysine N-methyltransferase CLF
- Histone-lysine N-methyltransferase MEDEA
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
- Histone-binding protein MSI1
- Histone-lysine N-methyltransferase EZA1
- Polycomb group protein VERNALIZATION 2
- Lysine-specific demethylase ELF6
- WD-40 repeat-containing protein MSI5
- VIN3-like protein 1
Sequence:
MSKITLGNESIVGSLTPSNKKSYKVTNRIQEGKKPLYAVVFNFLDARFFDVFVTAGGNRITLYNCLGDGAISALQSYADEDKEESFYTVSWACGVNGNPYVAAGGVKGIIRVIDVNSETIHKSLVGHGDSVNEIRTQPLKPQLVITASKDESVRLWNVETGICILIFAGAGGHRYEVLSVDFHPSDIYRFASCGMDTTIKIWSMKEFWTYVEKSFTWTDDPSKFPTKFVQFPVFTASIHTNYVDCNRWFGDFILSKSVDNEILLWEPQLKENSPGEGASDVLLRYPVPMCDIWFIKFSCDLHLSSVAIGNQEGKVYVWDLKSCPPVLITKLSHNQSKSVIRQTAMSVDGSTILACCEDGTIWRWDVITK
Protein: Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit ost2 (Oligosaccharyl transferase 16 kDa subunit) (Oligosaccharyl transferase subunit epsilon) (O14238)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3
- Uncharacterized protein C553.06
- Protein transport protein sec61 subunit beta
- Probable mannosyl-oligosaccharide glucosidase
- Dol-P-Glc:Glc
- Uncharacterized protein C19G7.17
- Protein transport protein sec61 subunit alpha
Sequence:
MSSKSGLFLPLSSVITSYNENTNLSLKTIDAFLGFLVVVGGLQFGYALLVGTYPFNSFLSGFISCVGQFVITVGFRMALTQQELQSSSSKKKSPVVSPYKRAFLEFCFSSLVLHFFAVNFLG
Protein: Glycosyl hydrolase DigH (EC 3.2.1.-) (Divisome-localized glycosyl hydrolase) (P64426)
Organism: Escherichia coli (strain K12)
Function: Divisome-localized glycosyl hydrolase that cleaves peptide-free (denuded) peptidoglycans. Has either glucosaminidase or muramidase activity.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:32152098}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. Note=Localizes to the divisome. {ECO:0000269|PubMed:32152098}.
Interaction partners:
Sequence:
MDICSRNKKLTIRRPAILVALALLLCSCKSTPPESMVTPPAGSKPPATTQQSSQPMRGIWLATVSRLDWPPVSSVNISNPTSRARVQQQAMIDKLDHLQRLGINTVFFQVKPDGTALWPSKILPWSDLMTGKIGENPGYDPLQFMLDEAHKRGMKVHAWFNPYRVSVNTKPGTIRELNSTLSQQPASVYVQHRDWIRTSGDRFVLDPGIPEVQDWITSIVAEVVSRYPVDGVQFDDYFYTESPGSRLNDNETYRKYGGAFASKADWRRNNTQQLIAKVSHTIKSIKPGVEFGVSPAGVWRNRSHDPLGSDTRGAAAYDESYADTRRWVEQGLLDYIAPQIYWPFSRSAARYDVLAKWWADVVKPTRTRLYIGIAFYKVGEPSKIEPDWMINGGVPELKKQLDLNDAVPEISGTILFREDYLNKPQTQQAVSYLQSRWGS
Protein: Agmatine deiminase (EC 3.5.3.12) (Agmatine iminohydrolase) (Q9I6J9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Mediates the hydrolysis of agmatine into N-carbamoylputrescine in the arginine decarboxylase (ADC) pathway of putrescine biosynthesis, a basic polyamine.
Interaction partners:
- N-carbamoylputrescine amidohydrolase
- Biosynthetic arginine decarboxylase
- Transcriptional regulator AguR
- ornithine decarboxylase
- Lysine decarboxylase LdcA
- S-adenosylmethionine decarboxylase proenzyme
- CN hydrolase domain-containing protein
- Arginine deiminase
- Multidrug resistance protein MexB
- S-adenosylmethionine decarboxylase proenzyme
Sequence:
MSNPTSTPRADGFRMPAEWEPHEQTWMVWPERPDNWRNGGKPAQAAFAAVAKAIARFEPVTVCASAGQYENARARLDDGNIRVVEISSDDAWVRDTGPTFVIDDKGDVRGVDWGFNAWGGFEGGLYFPWQRDDQVARKILEIERRARYRTDDFVLEGGSIHVDGEGTLITTEECLLNHNRNPHLSQAEIERTLRDYLAVESIIWLPNGLYNDETDGHVDNFCCYARPGEVLLAWTDDQDDPNYLRCQAALRVLEESRDAKGRKLVVHKMPIPGPLYATQEECDGVDIVEGSQPRDPSIRLAGSYVNFLIVNGGIIAPSFDDPKDAEARAILQRVFPEHEVVMVPGREILLGGGNIHCITQQQPAPRKA
Protein: Glutathione peroxidase (A8WFK6)
Organism: Caenorhabditis elegans
Interaction partners:
- Thioredoxin domain-containing protein
- Glutathione reductase, mitochondrial
- Glutathione peroxidase
- Glutathione peroxidase 3
- Glutathione synthetase
- Thioredoxin domain-containing protein
- Glutathione peroxidase 1
- Glutathione peroxidase 2
- glutathione-specific gamma-glutamylcyclotransferase
- Glutathione S-transferase 4
Sequence:
MYVQKLVNDDNAFHFFISLLNQRLKIDMSTGTIYDFSVRDNSGDLVSLDKYSGLVVIIVNVASYCGLTNSNYKELKSLNDKYHLRGLRVAAFPCNQFGFQEPHCEADINKFVNEKFSFEPDLYGKVTVNGGPLIGEEEPLWTFLKKEQGGTLFDAIKWNFTKFLVNRQGKVVARFGPSTNPKSFEEEIVKLLDENKL
Protein: Translocase of chloroplast 120, chloroplastic (AtToc120) (EC 3.6.5.-) (120 kDa chloroplast outer envelope protein) (Q9LUS2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000250|UniProtKB:O23680}; Single-pass membrane protein {ECO:0000250|UniProtKB:O23680}. Cytoplasm {ECO:0000250}. Note=Cycles between the cytoplasm and chloroplast, probably as a soluble preprotein receptor. The anchoring to the chloroplast outer membrane required the GTPase activity and GDP. May contain beta barrel transmembrane regions (By similarity). {ECO:0000250}.
Interaction partners:
- Protein TOC75-3, chloroplastic
- Protein TOC75-4, chloroplastic
- Protein TIC 56, chloroplastic
- Protein TIC110, chloroplastic
- Outer envelope protein 80, chloroplastic
- Short-chain dehydrogenase TIC 32, chloroplastic
- Chloroplast envelope quinone oxidoreductase homolog
- Protein TIC 40, chloroplastic
- Protein TIC 20-I, chloroplastic
- Outer envelope pore protein 37, chloroplastic
Sequence:
MGDGAEIVTRLYGDEKKLAEDGRISELVGSDEVKDNEEEVFEEAIGSQEGLKPESLKTDVLQEDFPLASNDEVCDLEETSRNERGVENLKVNYSEIGESHGEVNEQCITTKEADSDLVTLKMNDYDHGEVADADISYGKMASSLDVVENSEKATSNLATEDVNLENGNTHSSSENGVVSPDENKELVAEVISVSACSVETGSNGIDDEKWEEEIDVSAGMVTEQRNGKTGAEFNSVKIVSGDKSLNDSIEVAAGTLSPLEKSSSEEKGETESQNSNGGHDIQSNKEIVKQQDSSVNIGPEIKESQHMERESEVLSSVSPTESRSDTAALPPARPAGLGRAAPLLEPAPRVTQQPRVNGNVSHNQPQQAEDSTTAETDEHDETREKLQFIRVKFLRLSHRLGQTPHNVVVAQVLYRLGLAEQLRGRNGSRVGAFSFDRASAMAEQLEAAAQDPLDFSCTIMVLGKSGVGKSATINSIFDELKISTDAFQVGTKKVQDIEGFVQGIKVRVIDTPGLLPSWSDQHKNEKILKSVRAFIKKSPPDIVLYLDRLDMQSRDSGDMPLLRTITDVFGPSIWFNAIVGLTHAASAPPDGPNGTASSYDMFVTQRSHVIQQAIRQAAGDMRLMNPVSLVENHSACRTNRAGQRVLPNGQVWKPHLLLLSFASKILAEANALLKLQDNIPGGQFATRSKAPPLPLLLSSLLQSRPQAKLPEQQYDDEDDEDDLDESSDSEEESEYDELPPFKRLTKAEMTKLSKSQKKEYLDEMEYREKLFMKRQMKEERKRRKLLKKFAAEIKDMPNGYSENVEEERSEPASVPVPMPDLSLPASFDSDNPTHRYRYLDTSNQWLVRPVLETHGWDHDIGYEGVNAERLFVVKDKIPVSFSGQVTKDKKDAHVQLELASSVKHGEGRSTSLGFDMQNAGKELAYTIRSETRFNKFRKNKAAAGLSVTLLGDSVSAGLKVEDKLIANKRFRMVMSGGAMTSRGDVAYGGTLEAQFRDKDYPLGRFLSTLGLSVMDWHGDLAIGGNIQSQVPIGRSSNLIARANLNNRGAGQVSIRVNSSEQLQLAVVALVPLFKKLLTYYSPEQMQYGH