wanglab/gogpt-training-data huggingface dataset:
Protein: Thrombospondin 1 (A0A0G2JV24)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Platelet glycoprotein 4
- Lysosome membrane protein 2
- Leukocyte surface antigen CD47
- Calreticulin
- Calreticulin
- Integrin beta-1
- Transforming growth factor beta-1 proprotein
- Matrix metalloproteinase-9
- Calreticulin
- Scavenger receptor class B member 1
Sequence:
MELLRGLGVLFLLHVCGSNRIPESGGDNGVFDIFELIGGARKVPGRRLVKGQDLSSPAFRIENANLIPPVPDDKFQDLLDAVWADKGFIFLASLRQMKKTRGTLLAVERKDNSGQIFSVVSNGKAGTLDLSLSLPGKQQVVSVEEALLATGQWKSITLFVQEDRAQLYIDCDKMESAELDVPIQSIFTRDLANVARLRVAKGDVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSATNVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGLSCDELSSMVLELRGLRTIVTTLQDSIRKVTEENRELASELRRPPLCFHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSATCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWSPWSLWDICSVTCGGGVQRRSRLCNNPTPQFGGKDCVGDVTENQVCNKQDCPIDGCLSNPCFAGAKCTSYPDGSWKCGACPPGYSGNGIQCKDVDECKEVPDACFNHNGEHRCKNTDPGYNCLPCPPRFTGSQPFGRGVEHAMANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAVDIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDRDNCRLVPNPDQKDSDGDGRGDACKDDFDHDNVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGGRLGLFVFSQEMVFFSDMKYECRDS
Protein: Acetyl-CoA decarbonylase/synthase complex subunit beta 2 (ACDS complex subunit beta 2) (EC 2.3.1.169) (ACDS complex acyltransferase 2) (Q9V2Z4)
Organism: Methanosarcina thermophila
Function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).
Interaction partners:
Sequence:
MSEFPFEISPMFEGERVRKEGMFVELGGPKSLGLELVRAKPMDEIEDGKVTIVGPDLKDMEEGKTYPWAMIFHVGGELVEPDLESVIERRVHDFINYCQGIMHLNQRYDVWMRISKDTAAKMDSFEPFGKAVMMLFKTELPFIEKMQVTFYTDQAEVEKQMAEAMEIFKARDARTKDLHDEDVDVFYGCTLCQSFAPTNVCVVSPDRVSLCGAINWFDGRAAAKVDPEGPQFAIEKGELLDAKTGEYSGVNEVAKKLSSGEFDKIKLHSFFDAPHTSCGCFEVVGFYIPEVDGIGWVNREYQGMAPNGLGFSTMAGQTGGGKQIVGFLGIGINYFYSPKFIQADGGWNRVVWLPSMLKEKIDEAIPDDMKDKIATEKDVTDIESLKTFLKEKNHPVVANWAAEAEEEEEEEEEEEEVAAEAAPMMMPAAGFQMPAMPAMPMMSGGAGGIKLTFKNAKITIDRMIISEKKEKK
Protein: High temperature lethal protein 1 (Chromatin structure-remodeling complex protein HTL1) (Q9URQ5)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for cell cycle progression through G2/M transition at temperatures higher than 33 degrees Celsius. Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. When associated with the RSC complex, may act coordinately with PKC1 to regulate G2/M transition. Together with LDB7, NPL6, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity.
Subcellular location: Nucleus {ECO:0000269|PubMed:12417720}.
Interaction partners:
- Chromatin structure-remodeling complex protein RSC8
- Chromatin structure-remodeling complex protein RSC6
- Chromatin structure-remodeling complex subunit RSC4
- Chromatin structure-remodeling complex subunit RSC7
- Nuclear protein STH1/NPS1
- Chromatin structure-remodeling complex protein RSC58
- Chromatin structure-remodeling complex protein RSC14
- Chromatin structure-remodeling complex subunit RSC2
- Chromatin structure-remodeling complex protein RSC3
- Chromatin structure-remodeling complex protein RSC30
Sequence:
MSQNNTISSMNPERAYNNVTLKNLTAFQLLSQRENICELLNLVESTERHNSIINPERQRMSLEEMKKMLDALKNERKK
Protein: Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (EC 1.3.1.124) (2,4-dienoyl-CoA reductase 2) (A0A8I6AJE6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTQQPPDVEEDDCLSEYHHLFLGARVKNESATGWCVPHTFLLRPAFSVCRHGCHTVIVSRSLPRVSEAAKKLVAATGKRCLPLSMDVRVPPAVMAAVDQALKEFGKIDILINCAAGNFLCPASALSFNAFKTVVDIDTLGTFNVSRVLYEKFFRDHGGVIVNITATLSMRGQVLQLHAGAAKAAVDAMTRHLAVEWGPQNIRVNSLAPGAISGTEGLRRLGGPKASSKFKYLSSPIPRLGTKTEIAHSVLYLASPLASYVSGIVLVVDGGSWMTLPNDIGRLLEFESSSAKL
Protein: Heat stress transcription factor B-4 (AtHsfB4) (AtHsf-02) (Q9C635)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- Heat shock 70 kDa protein 4
- At2g44430
Sequence:
MAMMVENSYGGYGGGGGERIQLMVEGQGKAVPAPFLTKTYQLVDDPATDHVVSWGDDDTTFVVWRPPEFARDLLPNYFKHNNFSSFVRQLNTYGFRKIVPDRWEFANEFFKRGEKHLLCEIHRRKTSQMIPQQHSPFMSHHHAPPQIPFSGGSFFPLPPPRVTTPEEDHYWCDDSPPSRPRVIPQQIDTAAQVTALSEDNERLRRSNTVLMSELAHMKKLYNDIIYFVQNHVKPVAPSNNSSYLSSFLQKQQQQQPPTLDYYNTATVNATNLNALNSSPPTSQSSITVLEDDHTNHHDQSNMRKTKLFGVSLPSSKKRSHHFSDQTSKTRLVLDQSDLALNLMTASTR
Protein: Alpha-methylacyl-CoA racemase (AMACR) (EC 5.1.99.4) (MtMCR) (O06543)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the epimerization of (2R)- and (2S)-methylacyl-coenzyme A (CoA) thioesters. Accepts as substrates a wide range of alpha-methylacyl-CoAs, including (2R)-2-methylmyristoyl-CoA and (2S)-2-methylmyristoyl-CoA, (2R)-pristanoyl-CoA and (2S)-pristanoyl-CoA, and the cholesterol esters (25R)-3-oxo-cholest-4-en-26-oyl-CoA and (25S)-3-oxo-cholest-4-en-26-oyl-CoA. Can also catalyze the interconversion of the non-physiologic substrates (2R)-ibuprofenoyl-CoA and (2S)-ibuprofenoyl-CoA, which are potential competitive inhibitors of the enzyme.
Interaction partners:
- Uncharacterized oxidoreductase Rv1144
- Alpha-methylacyl-CoA racemase
- Probable enoyl-CoA hydratase EchA10
Sequence:
MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSVDGISRDAMLRNRRIVTADLKSDQGLELALKLIAKADVLIEGYRPGVTERLGLGPEECAKVNDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHAIGRGDERPVPPLNLVGDFGGGSMFLLVGILAALWERQSSGKGQVVDAAMVDGSSVLIQMMWAMRATGMWTDTRGANMLDGGAPYYDTYECADGRYVAVGAIEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLTEAFASHDRDHWGAVFANSDACVTPVLAFGEVHNEPHIIERNTFYEANGGWQPMPAPRFSRTASSQPRPPAATIDIEAVLTDWDG
Protein: ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) (Q7KTC2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Vacuole membrane {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004128}.
Interaction partners:
Sequence:
MADDTSSPMDRFCGSTFWNATETWYTNDPDFTPCFEQTALVWTPCAFYWAFVIFDFYYLKASLDRNIPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGPIIKFATFLLLFIFIPLNRKYGVQTTGCQFIFWFLLTVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSWEEYQFVSFFIFFTFTSIMLILNCFADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYGAFGFGQVVTGYLSTLILSLGCVYSARYMHNVLLHGTLRWPMEMFDITPLGRIVNRFSKDVDTIDNTLPLNLRVVILQLFAVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKDANLV
Protein: Membrane protein (A0A0H2UPN3)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MTELAKQLLELTYIVIGCQFLHTAYCSYKDKTNPVRLGTSAFWTLLSITFIGGSYMPNMSIGIIVILLSLLTLFKQVRIGTLPSLDEMKANIESNRLKNKIFIPVMLMAILALVLAQMIPEFSKISISLAALFATISVLVITNSHPKSLLSENNRMTQQVSTSGIVPQLLGALGAIFTVAGVGDVISHLISGIVPSDSRFIGVLAYVLGMVLFTMIMGNAFAAFTVITAGVGVPFVFALGANPIVAGALAMTAGYCGTLLTPMAANFNALPAALMDMKDQNGVIKAQAGVALVMIVIHIFLMYFLAF
Protein: Nebulette (Q90684)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
DLEEWMKGKGMTVFEDTPDLIRVKNAAQILNEKQYKKDLETEIKGKGMQVGPDTPEIRRAKKASEIASTKDYKKDLENEIKGKGMEVGMDTPDIQRAKKASEIVSQKEYRKDLETEIIGKGMQVGPFTPEIQRCQKSPSKLEAAECQDEAEKMLCNYSAVPDTPEMERIKSTQKNISSVFYKKVVGAGTAVKETPEIERVKKNQQNISSIKYKEETQHATPISDPPELRRIKENQKNISNVHYKEQLCRATPVSVTPEIERVKRNQENVSMVHYREQPGKATAVSITPEIERVKKNQDNISSVKYSSDQRQMKGRRSVILDTPELRHVKETQNNISMVKYHEDFEKTKGRGFTPVVDDPITERVRKNTQVVSDAAYKGDS
Protein: Cytochrome P450 11B3, mitochondrial (CYPXIB3) (Cytochrome P-450 11B3) (CYP11B3) (Cytochrome P450-Aldo-2) (Steroid 11-beta-hydroxylase) (EC 1.14.15.4) (P30100)
Organism: Rattus norvegicus (Rat)
Function: Converts 11-deoxycorticosterone into corticosterone, 18-hydroxycorticosterone, and aldosterone. Can also catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone.
Subcellular location: Mitochondrion membrane.
Interaction partners:
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
- 11-beta-hydroxysteroid dehydrogenase type 2
- Steroid 21-hydroxylase
- Steroid 17-alpha-hydroxylase/17,20 lyase
- NADPH-dependent 3-keto-steroid reductase Hsd3b5
- 17-beta-hydroxysteroid dehydrogenase type 3
- Aromatase
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
- Aldo-keto reductase family 1 member C15
- Polyprenal reductase
Sequence:
MALRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMHLEPWVAHRELRGLRRGVFLLNGAEWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLEALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSLKFIHALHSMFKSTTQLLFLPRSLTRWTSTQVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAALITQGALPLDAIKANSMKLTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPIS
Protein: Dual specificity protein phosphatase 2 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PAC-1) (Q05923)
Organism: Homo sapiens (Human)
Function: Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine. Can dephosphorylate MAPK1 (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Mitogen-activated protein kinase 8
- Mitogen-activated protein kinase 9
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 11
- Mitogen-activated protein kinase 12
- SNF-related serine/threonine-protein kinase
- Mitogen-activated protein kinase 13
Sequence:
MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRARGPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRAGPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLCH
Protein: XK-related protein 8 (mXkr8) [Cleaved into: XK-related protein 8, processed form] (Q8C0T0)
Organism: Mus musculus (Mouse)
Function: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina. Has no effect on calcium-induced exposure of phosphatidylserine (By similarity). Promotes myoblast differentiation and survival.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25231987}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9H6D3}.
Interaction partners:
- Phospholipid-transporting ATPase 11C
- Basigin
- Anoctamin-6
- Phospholipid-transporting ATPase IH
Sequence:
MPLSVHHHVALDVVVGLVSILSFLLDLVADLWAVVQYVLLGRYLWAALVLVLLGQASVLLQLFSWLWLTADPTELHHSQLSRPFLALLHLLQLGYLYRCLHGMHQGLSMCYQEMPSECDLAYADFLSLDISMLKLFESFLEATPQLTLVLAIVLQNGQAEYYQWFGISSSFLGISWALLDYHRSLRTCLPSKPRLGRSSSAIYFLWNLLLLGPRICAIALFSAVFPYYVALHFFSLWLVLLFWIWLQGTNFMPDSKGEWLYRVTMALILYFSWFNVSGGRTRGRAVIHLIFIFSDSVLLVTTSWVTHGTWLPSGISLLMWVTIGGACFFLGLALRVIYYLWLHPSCSWDPDLVDGTLGLLSPHRPPKLIYNRRATLLAENFFAKAKARAVLTEEVQLNGVL
Protein: U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) (O43172)
Organism: Homo sapiens (Human)
Function: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Subcellular location: Nucleus {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9257651, ECO:0000269|PubMed:9328476, ECO:0000269|PubMed:9404889}. Nucleus speckle {ECO:0000305}.
Interaction partners:
- Small nuclear ribonucleoprotein E
- Pre-mRNA-processing factor 6
- U4/U6.U5 tri-snRNP-associated protein 1
- U4/U6 small nuclear ribonucleoprotein Prp31
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Small nuclear ribonucleoprotein F
- Peptidyl-prolyl cis-trans isomerase H
- U6 snRNA-associated Sm-like protein LSm8
- 116 kDa U5 small nuclear ribonucleoprotein component
- NHP2-like protein 1
Sequence:
MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE
Protein: Spastin (EC 5.6.1.1) (D-Spastin) (Dm-Spastin) (Dspastin) (Q8I0P1)
Organism: Drosophila melanogaster (Fruit fly)
Function: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Subcellular location: Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:17452528}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15562320, ECO:0000269|PubMed:15823537, ECO:0000269|PubMed:17452528, ECO:0000269|PubMed:18202664}. Chromosome {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:17452528}. Lipid droplet {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:25875445}. Note=Forms a intramembrane hairpin-like structure in the membrane (By similarity). Colocalizes with cellular microtubule arrays. Localizes to chromosomes from prometaphase/metaphase to anaphase, and this requires microtubules (PubMed:17452528). Localizes to discrete punctate cytoplasmic foci which may correspond to secretory vesicles (PubMed:15823537). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15823537, ECO:0000269|PubMed:17452528}.
Interaction partners:
- IST1 homolog
- Atlastin
- Protein spartin
- Receptor expression enhancing protein A, isoform I
- Charged multivesicular body protein 1, isoform A
- GH14561p
- Reticulon-like protein
- Seipin
- Patronin
- Katanin p80 WD40 repeat-containing subunit B1
Sequence:
MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGLGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDITI
Protein: AT4g02370 protein (T14P8.18) (O81296)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Exocyst complex component SEC8
- Exocyst complex component SEC6
- Exocyst complex component SEC3B
- Exocyst complex component SEC3A
- Exocyst complex component SEC5B
- Exocyst complex component SEC5A
- Exocyst complex component EXO84B
- Exocyst complex component EXO84C
- Exocyst complex component EXO84A
- RPW8-like protein 3
Sequence:
MSRLPILIASCLFLSSLTAAVVTAAESDTPTAYSLLQSYNFPVGILPKGVVAYDLDTTTGKFHAYFNDSCSFNLVGSYQLNYKSTISGYISENKLKKLTGVKVKVLFLWLNIVEVIRNGDEMEFSVGITSANFAIQEFLESPQCGCGFECKDSKLDMIERIPFLSSS
Protein: FI17310p1 (Signal peptide peptidase-like, isoform A (EC 3.4.23.-)) (Signal peptide peptidase-like, isoform B) (Signal peptide peptidase-like, isoform C) (Signal peptide peptidase-like, isoform F) (Q9VBL1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MSHGGAGGGLGAQTVGAGQLGGGAAAAGGGEYRELHWTVSSVMDSSRVSTCLISMLLIVYGSFRSLNIEQEAREREQKKRNESMTNLLTGEPVEKEPTDKFATLDTMHALCLPLGASISLLIMFFFFDSMQLLFAVCTAIIATVALAFLLLPMCQYIIRPCTDGKRFSFGFCGRFTAAELFSFTLSVSIVCIWVLTGHWLLMDAMGMGLCVAFIAFVRLPSLKVSTLLLTGLLIYDVFWVFLSSYIFSTNVMVKVATRPADNPVGIVARKLHLGGIVRDTPKLNLPGKLVFPSLHNTGHFSMLGLGDVVMPGLLLCFVLRYDAYKKAQGVTSDPTLSPPRGVGSRLTYFHCSLLGYFLGLLTATVSSEVFKAAQPALLYLVPFTLLPLLLMAYLKGDLRRMWSEPFIAQQPSKQLEV
Protein: Small ribosomal subunit protein mS26 (28S ribosomal protein S26, mitochondrial) (H6UQ73)
Organism: Gallus gallus (Chicken)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAPGGCLLLALLLLAGTAQGQHWSHGWYPGGKRDLSAPQAIPAWSPWLVPSRGRKSRYDPPAKSKASRLKVPPPVDPAELYVVTERYRQHRLVLSALRSIFRSEVVQRKSEAQRDAEDSAALSEEHRLLMAWNDAENARQRARR
Protein: Tubby-like F-box protein 6 (AtTLP6) (Q0WPY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable ADP-ribosylation factor GTPase-activating protein AGD13
- Shaggy-related protein kinase beta
- Protein PLANT CADMIUM RESISTANCE 11
- F-box protein At3g62230
- Anther-specific protein BCP1
- 26S proteasome non-ATPase regulatory subunit 7 homolog B
- Protein MEI2-like 4
Sequence:
MDLSLLLPKRSWEISGGADKISRVAMSLKNIVKNKYKAIGRRGRSHIAPEGSSVSSSLSTNEGLNQSIWVDLPPELLLDIIQRIESEQSLWPGRRDVVACASVCKSWREMTKEVVKVPELSGLITFPISLRQPGPRDAPIQCFIKRERATGIYRLYLGLSPALSGDKSKLLLSAKRVRRATGAEFVVSLSGNDFSRSSSNYIGKLRSNFLGTKFTVYENQPPPFNRKLPPSMQVSPWVSSSSSSYNIASILYELNVLRTRGPRRMQCIMHSIPISAIQEGGKIQSPTEFTNQGKKKKKPLMDFCSGNLGGESVIKEPLILKNKSPRWHEQLQCWCLNFKGRVTVASVKNFQLVAAAAEAGKNMNIPEEEQDRVILQFGKIGKDIFTMDYRYPISAFQAFAICLSSFDTKPVCE
Protein: Transcription factor TFIIIB component B'' (Transcription factor TFIIIB complex subunit bdp1) (O94481)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: General activator of RNA polymerase III transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:16823372}.
Interaction partners:
- TATA-box-binding protein
- Transcription factor IIIB 60 kDa subunit
- Transcription factor tau subunit sfc4
- Probable DNA-directed RNA polymerase III subunit rpc6
- DNA-directed RNA polymerase III subunit rpc5
- DNA-directed RNA polymerase III subunit rpc1
- DNA-directed RNA polymerase III subunit rpc9
- DNA-directed RNA polymerase III subunit rpc4
- DNA-directed RNA polymerase III subunit rpc3
- Transcription factor tau subunit sfc1
Sequence:
MSSQILTSPTKKSMSRFAPKFTARREKVSDQKEVVHEEKNQPLTGNEVETSAQLSRDTANADISSPVVQTVVHKEATENPTASSYRKDDSVKQNEKLLHSNPTFKISKPTVLEQPLNAIEHLSPETDLSSSAEQQFMKELDLFFDENIPLSQLSAVSDGKADSPATKKSRRSYRESSLKRKSQLILENVGTDEKIINISETKMSALCDDPGIGRKSQRFIELEKMLFEEKRAKRIKKQGASTASSSREASLDSTIKQPLSASLLESSEPKEKEEIVGSLEEEGTDESASLEDSLSHPTKSILDQLADKMEVDGLNNNSNYSATPRTRVVNGQIVLDETSLEVDRHERDFVPAEEREYVEENSLSRRVTSATWGNRQKPEKWNAMDTEKFYKALSQWGTDFALIANMFPTRNRRQIKLKFKQEERRNPARVNQALKIKKPIDMEEYSKVSGKVFRPVEEMEKELQKIRENFEEERRRAIEVAEQRQLIVNHELEQEKNAPSPTDDKSYVFEDGVEVVGQVV
Protein: ACP53C14C (Q6GUV4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKSKQVFYIAFSLLLLGSLLPNDVESLRVDLNKLAECTESGLKVATTLIVRAIPCVKKLAKCADFRAIKTKDLDITALTLLGYQYLQTVVNNQRCLLISLKEGYDAVSPHLDKLISGKCLPGLS
Protein: Heat shock transcription factor 1 isoform a (Q76M54)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEFHGGGSGGVVVSGSNVPAFLMKLWTLIEDPDTDPLICWSPNGNSFHVFDQGQFSKDVLPRYFKHSNMTSFVRQLNMYGFRKVVHIEQGGLVKPEKDDMEFQHPYFIRGQEPLLENIKRKVTNVSNAKHEDLKMSSDDVSKILTNVQNIKGKQETIDSQIIAMKHENETLWREVASLRQKHVQQQKVVNKLIQFLVTLVQSNRVLGMKRKIPLMLNDSSSAHSMPKYSRQYSLEHLQASSSISPSGSSFTSTGLFTAESSLNNGPIISDVTDLAQASHVEVTNEWMEESTSPLVHIKEEPSSHVLEEVCPAEVVIGGAGVQVDTPLSPINFINSILQESNEPNAASTPTTPTEQKCLSLACLDKSELSDHLDSIDNGLENLQTILNAQSINFESSPFFEFFSSSLPGSEFDLESLDSIQDLLSSDPPKGAERSDNYTAGKQLVQYTNQPMLLTDPLTNENGGADLPTLLEGDFYFSQDPEEEPTISLTSDIAAPDKPKLS
Protein: Sarcosine dehydrogenase (EC 1.-.-.-, EC 1.5.8.3) (A1ZAZ2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glycine cleavage system P protein
- Serine hydroxymethyltransferase
- Glycine N-methyltransferase
- D-amino acid oxidase 2, isoform A
- Alanine--glyoxylate aminotransferase
- 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
- 5-aminolevulinate synthase
- LD34157p
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- RE02644p
Sequence:
MWRHRILQQASRRGISKQVREDGGARREPSGFLPGAADVVVIGGGSAGCHTLYHLARRGVKAVLLERAQLTAGTTWHTAGLLWRLRPNDVDIQLLANSRRMLQQLEEETELDPGWIQNGGIFIAHNETRLDEYRRLATVGSALGIENQVLSPEDTQKLFPLLDPSAFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVIENCGVDDLLLEQTARGKKVVGVSTPFGDIKAEKVVNATGVWGRDLVARHGTHLPLVPMKHAYIVSESIPGVRGLPNIRDHDYSTYFRIQGDAICMGGYEPNPILLEPVPKDFHFGLYELDWSVFETHVEGAQKLCPSYAKYGVKSTVCGPESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFGGGCGEQTALWVIQGQPDLPMFGFDLRRFTQEQGKAIQWIREKSHESYVKNYSMVFKYDQPLAGRDFQKDPLHDEMMKAGAVMEEKQGWERPGFFLPTGSKKAVVQPYDWYGSYVHQRHKDSEYERVLDGDLHYSRFSEYHDLIGSEALACRNNAVVFNMSYFAKLLLDGPQAQEAADWLFSANTNRDPSKTVYTCALNDAGGVEADVTISRLAPGSGEVYNPKINGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASLKDLTAELGVISIQGPNSRKILQPLIDCDLSDEHVAPNSTRLAKFGDVGLRLLRVSFVGELGYELHVPKKDCAAVYRSLMKAGAGEDLRNAGYRSLYSLSSEKGYHLWSFDLRPDDTPLEAGLGFTCRKTGADYRGKAAIENQRAEGLKKRLVYLTLRDQVPIWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQTYVSRPDGKIIDADYIRNGEYEVDILGKKYRADCHLRSPFDPTGQRVLGNYASESKSNK