wanglab/gogpt-training-data huggingface dataset:
Protein: Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase (EC 2.4.1.-) (Alpha-D-mannose-alpha-(1-2)-mannosyltransferase) (Alpha-mannosyltransferase) (Alpha-ManT) (PPM-dependent mannosyltransferase) (Polyprenol-phosphate-mannose alpha-mannosyltransferase) (PPM alpha-mannosyltransferase) (P9WMZ9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Responsible for the addition of alpha-(1-2) mannose branches to the linear mannan core on the biosynthetic pathway to mature lipoarabinomannan (LAM).
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable mannosyltransferase. Probable conserved transmembrane protein
- Alpha-
- Alpha-
- Probable arabinosyltransferase C
- 3'-5' exoribonuclease Rv2179c
- Probable conserved integral membrane protein
- Alpha-
- Anti-sigma-M factor RsmA
- Terminal beta-
- Phospho-2-dehydro-3-deoxyheptonate aldolase AroG
Sequence:
MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRIDIDIYQMGARAWLDGRPLYGGGVLFHTPIGLNLPFTYPPLAAVLFSPFAWLQMPAASVAITVLTLVLLIASTAIVLTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPISSNFAFGQINVVLMTLVIVDCFPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRAALTALASFAVATLLGFVLAWRDSWEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIGDDERFALWVAGSLLVLAATIWAMRRVLRAGEPTLAVICVALFGLVVSPVSWSHHWVWMLPAVLVIGLLGWRRRNVALAMLSLAGVVLMRWTPIDLLPQHRETTAVWWRQLAGMSYVWWALAVIVVAGLTVTARMTPQRSLTRGLTPAPTAS
Protein: ABC transporter B family member 3 (ABC transporter ABCB.3) (Q8T9W4)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- ABC transporter B family member 2
Sequence:
MDDGNENNENAQHDEYDEEEIEIPIDEIIIEEVDDDHLLEGEGEFQIITQPSNNNNNSNNNNFGDIYVSNPNTPRNNNNNNNNNNNNNNNNNNNNNNNSNNSFNNNKKNEVSIGISENTNENNNKNNNNNNNNNDDYNDGADERVKTEEEIKKEAENELNQSVPFLSLFRFADNTDKVLMFLGTIAAVINGAAMPTVSLVFGLVVDAFKPTQFNDDPNYDIYDTVRSISFYLLMLGGGVFVLSYLETTLWMIAGERQTSRIRREYLESTLRQEIGWFDTNKANELSSRINSDTVLFEEAIGEKVGRFIHFFSTFVAGFVIGFTKGWQLTLVITSVSPLLAIGGFFTAKMMTQMTKLGQEAYSRAGGVAEENIGSIRTVATFSGEKLAIDKYSNNLKDARTVGYKRSFFNGLGLGFVQFVILGTYALAFWYGSTLISNKVTNSVSDRPWTGGDVVSVFFAVIIGATSIGQASPCLALFAQGRGAAYKIFQVIDRQSKANPFSTRGIKPETLSGEIEFKDVGFHYPSRPDVPIFNGFNLKIKPGQTVGLVGDSGGGKSTIISLLERFYDPCQGEILLDGEDIRKFNVRGLRQKIGLVNQEPVLFATTISENIRYGKEGATQDEIEEAAKLANAHSFISQLPQGYNTLVGEKGVQMSGGQRQRIAIARAVIKNPNILLLDESTSALDAESTKLVQEALDVLMKGRTTIVIAHNLSTIRNADVIIYIKKGVAVERGTHDELMAKQGLYFDLVEKQSHQQMYNLLENGTRSRRSSTFSAEVNPLLDSFHVSKRSLRKNESESNKKDKEDSNNKKKKKSNKKKVEEVPMSRVVKYNRPELGLWCFGFLSAVGTGAVYPGFAMVFTEMLTIFQNPDPNYLTDHANFVALMFVALAVGAGISNFFQGFLFSVIGEKLTYRLRRDCFAAIMRQDVGWFDLPENSTGKLTSHLATDAALVQGMTSQRLGIVLQNILTMVGGLVIAFYSGWQLTLVIIACFPLVVITSKVQMQILAGFSSKDGCGPAGQVASEAISGIRTVASFTTEKQVVELYKKQQKGPSSEGIKKAHISGFAFGFTQLILFCVYCLSFWYGGKLVGSGVFGATDKEISDNCTPQTIPYLWKDYDTCERAQNTIYGFNSMTRVFFAIVMSAIGVGQASSFAPDLAKAKAAAVSVFKLLDTPSKIDPTTEDGDRIDIVGGDIEFKNLHFSYPTRPDNSVFRGFTLTLQSGTTTALVGDSGGGKSTCLSLLQRFYNPVVGEIFIDGHNIKNLNVRHLRHLFGLVGQEPTLFSGTIADNIRYGKHDATQEEIEEASKLSNSHSFIIDLPNGYNTELGEKYTQLSGGQKQRIAIARAIIRNPKILLLDESTSALDADSTKLVQEALENVMKGRTTIVIAHNLLTIQNADCIAYVRAGQIIERGTHDELLEAEGPYSQLWYNQQQK
Protein: Two-component response regulator ORR10 (OsRR10) (OsRRA2) (Q2QXY3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
Subcellular location: Nucleus {ECO:0000269|PubMed:22383541}.
Interaction partners:
Sequence:
MAVAIEAPFHVLAVDDSLPDRKLIERLLKTSSFQVTTVDSGSKALEFLGLHDHEDSPISTQSDQQEVGVNLIITDYCMPGMTGYDLLKKIKESSYLRDIPVVIMSSDNIPSRINRCLEEGADEFFLKPVRLSDMSKLKPHILKSRCKEHYQQEQHLQSNSESNNSSNPTSENSSSSTSTNSHKRKAVDEEILPHTIRPRHS
Protein: mRNA export factor ICP27 homolog (Q6SW73)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Immediate early (EI) protein that plays many roles during productive infection including regulation of host cell cycle progression, regulation of viral gene expression or nuclear export of intronless viral RNAs. Acts as a transcriptional transactivator via interaction with the cellular transcription elongation factor SUPT6H and as a nuclear RNA export factor via interaction with UAP56, a component of the cellular mRNA export machinery (By similarity).
Subcellular location: Virion tegument {ECO:0000250}. Virion {ECO:0000250}. Host nucleus {ECO:0000269|PubMed:17251556}. Host cytoplasm {ECO:0000269|PubMed:17251556}. Note=Shuttles between host nucleus and cytoplasm.
Interaction partners:
Sequence:
MELHSRGRHDAPSLSSLSERERRARRARRFCLDYEPVPRKFRRERSPTSPSTRNGAAASEYHLAEDTVGAASHHHRPCVPARRPRYSKDDDTEGDPDHYPPPLPPSSRHALGGTGGHIIMGTAGFRGGHRASSSFKRRVAASASVPLNPHYGKSYDNDDGEPHHHGGDSTHLRRRVPSCPTTFGSSHPSSANNHHGSSAGPQQQQMLALIDDELDAMDEDELQQLSRLIEKKKRARLQRGAASSGTSPSSTSPVYDLQRYTAESLRLAPYPADLKVPTAFPQDHQPRGRILLSHDELMHTDYLLHIRQQFDWLEEPLLRKLVVEKIFAVYNAPNLHTLLAIIDETLSYMKYHHLHGLPVNPHDPYLETVGGMRQLLFNKLNNLDLGCILDHQDGWGDHCSTLKRLVKKPGQMSAWLRDDVCDLQKRPPETFSQPMHRAMAYVCSFSRVAVSLRRRALQVTGTPQFFDQFDTNNAMGTYRCGAVSDLILGALQCHECQNEMCELRIQRALAPYRFMIAYCPFDEQSLLDLTVFAGTTTTTASNHATAGGQQRGGDQIHPTDEQCASMESRTDPATLTAYDKKDREGSHRHPSPMIAAAAPPAQPPSQPQQHYSEGELEEDEDSDDASSQDLVRATDRHGDTVVYKTTAVPPSPPAPLAGVRSHRGELNLMTPSPSHGGSPPQVPHKQPIIPVQSANGNHSTTATQQQQPPPPPPVPQEDDSVVMRCQTPDYEDMLCYSDDMDD
Protein: Tyrosine-protein kinase CpsD (EC 2.7.10.2) (Q9ZII6)
Organism: Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Interaction partners:
Sequence:
MPTLEISQAKLDFVKKAEEYYNSLCTNLQLSGDGLKVFSITSVKLGEGKSTTSTNIAWAFARAGYKTLLIDGDIRNSVMLGVFKARDKITGLTEFLSGTTDLSQGLCDTNIENLFVIQAGSVSPNPTALLQRKNFSTMLETLRKYFDYIIVDTAPVGVVIDAAIITRKCDASILVTEAGEINRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSYGDYGKNKK
Protein: rRNA-processing protein FCF1 (FAF1-copurifying factor 1) (Q05498)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16762320}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 5
- rRNA 2'-O-methyltransferase fibrillarin
- Ribosomal RNA small subunit methyltransferase NEP1
- U3 small nucleolar RNA-associated protein 10
- U3 small nucleolar RNA-associated protein 14
- U3 small nucleolar RNA-associated protein 7
- U3 small nucleolar RNA-associated protein 12
- U3 small nucleolar ribonucleoprotein protein IMP4
- U3 small nucleolar RNA-associated protein 9
- Something about silencing protein 10
Sequence:
MGKAKKTRKFGLVKRTLNTKKDQRLKKNQENIKTKEDPELTRNIPQVSSALFFQYNQAIKPPYQVLIDTNFINFSIQKKVDIVRGMMDCLLAKCNPLITDCVMAELEKLGPKYRIALKLARDPRIKRLSCSHKGTYADDCLVHRVLQHKCYIVATNDAGLKQRIRKIPGIPLMSVGGHAYVIEKLPDVF
Protein: SAGA-like transcriptional regulatory complex subunit Spt3, putative (AFU_orthologue AFUA_1G14030) (Q5BFG1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Transcriptional co-activator
- SAGA complex component
- Transcriptional adapter 2
- Transcriptional regulator Ngg1, putative
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 9
- Transcriptional activator spt7
- Ubiquitin C-terminal hydrolase Ubp8, putative
Sequence:
MSSDRTPKYRQEIQQMMFVSGETAEPSIETTTLIEDIVRQQVVELLARSTALATRRGVRSISTDDLIFLIRHDKAKVSRLKTFLSWKDVRKNVKDSDDKGGADAADFAGADDPMAGGVVAGPQDVASKPKNKKARVGLAWDVNSFYSVQVPERDDEEDEEEEEQNYATLQRLAAADERTKHMTREEYVFWSECRQASFTYRKSKRFREWAGFGIVTESKPNDDIVDILGFLTFEIVQTLTEEALKVKEREDREKNRRGGAENSAEDTKKRKRETGLFDPPEEGRTPVEPRHIREAYRKLQATPNKNIAMLLHNGRLPARMPLRLFLMGLSI
Protein: Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog) (rVLG) (Q64060)
Organism: Rattus norvegicus (Rat)
Function: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q61496}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q61496}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q61496}.
Interaction partners:
- Deleted in azoospermia-like.
- RAN binding protein 9
- Tudor domain-containing protein 1
- Piwi-like protein 1
- Piwi-like protein 2
- Stimulated by retinoic acid 8
- Synaptonemal complex protein 3
- ATP-dependent RNA helicase TDRD9
- Tudor domain-containing protein 6
- Muellerian-inhibiting factor
Sequence:
MGDEDWEAEILKPHVSSYVPVFEKDKYSSGANGDTFNRTSASSSEMEDGPSGRDHFMRSGFSSGRNLGNRDIGESSKRETTSTTGGFGRGKGFGNRGFLNNKFEEGDSSGFWKESTNDCEDTQTRSRGFSKRGGYPDGNDSEASGPFRRGGRDSEYDQDQGSQRGGGLFGSRKPAASDSGSGDTFQSRSGNARGAYKGLNEEVVTGSGKNSWKSEAEGGESSDIQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIVLAGRDLMACAQTGSGKTAAFLLPILAHMMRDGITASRFKELQEPECIIVAPTRELINQIYLEARKFSFGTCVRAVVIYGGTQFGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQVKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLLFSATFPEEIQRLAGEFLKSNYLFVAVGQVGGACRDVQQSILQVGPVFKKRKLVEILRNIGDERPMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRCGKCPVLVATSVAARGLDIENVQHVINFNLPSTIDEYVHRIGRTGRCGNTGRAISFFDTESDNHLAQPLVKVLSDAQQDVPAWLEEIAFSSYAPPSFSNSTRGAVFASFDTRKNFQGKNTLNTAGISSAQAPNPVDDESWD
Protein: Transmembrane protease serine 5 (EC 3.4.21.-) (Spinesin) (Q9H3S3)
Organism: Homo sapiens (Human)
Function: May play a role in hearing.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSLMLDDQPPMEAQYAEEGPGPGIFRAEPGDQQHPISQAVCWRSMRRGCAVLGALGLLAGAGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSFRINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSLL
Protein: Ubiquitin-conjugating enzyme E2, putative (EC 6.3.2.19) (Q583Z6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ubiquitin-conjugating enzyme, putative
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-like modifier-activating enzyme ATG7
- Uncharacterized protein
- Protein phosphatase 2C, putative
- Leucine-rich repeat protein
- Anaphase-promoting complex subunit 4 WD40 domain-containing protein
- Ubiquitin-conjugating enzyme E2, putative
- E2 ubiquitin-conjugating enzyme
- NEDD8-activating enzyme E1 catalytic subunit
Sequence:
MPAPPAASGVRRLQKELRDITLDPPPYCNAAPSSESIFTWYFTLDGLPQTPYEGGRYVGELRFPPEYPMKAPKIIMLTPSGRFVINSPICLTITDFHPEEWSPMWGVRTIITGLLSFMVSEESGLGGMTATAESRRALAAESHRYNVERVPVYKELFNSEYQKDLKKLNEEAEALRKNCGDVSEHLGNKTTNAGRAQLRGIVASIVVLVALAVGLLVLRN
Protein: Uncharacterized protein (Q54BI8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MPLNLVARKSLRDNEEHLNKAHEEIKNALNGEEWIIEFDWDAIFDKVDEHVKKQLGEVFYKNLCPNISKCIVNASKDELTKESIINANTAKKIVLIVNEDAKNSSYWKYAFNGGQLNLLFKKGCNNITEAGNFELYKVIPSEGAYSLPTRLNMKKNQERFELAFERIKVVTSRDWSFDEASMETVYPTAFEHESQREQFGTTFAQILEYVAQNIEKRCKDEMTLESFNDVTANGRISFRHNPKQTTGYWNWSFANGDLIITFKSISNISDNANYDFIKVLPVPGVFSLAARLNMKENQEKFDTAFERIKAATHMDWSYEQESLEQIYPALEERNKERIGDLFSDIFKYVADNIEKKCKNDTILEAFVEATSNAKIVFRHNAKASGYWNWTFEGGNLIITFKSICNISDNANFDFIKVLPVPGVFSLAAKINLKENQEKFDTAFERIKEVTKVDWSYDEQSLETVYPALEERNKERIGDLFQEIIKYVADNIVKRCKEDMVLESFLEATSNAKIVFRHNAKANGYWNWSFENNDLVITFKSICNVSDNANFDFIKILPSPGVLTLASRINLRENQEKINESFEKIKEVLGNDWTYDESSIEQVYPKLEENNKPRVGDVFAEIIRYISQNIVKRCKDDDMVKEGFVEATQNCKIVFQFVEKQSSYWVWKFDGGNLVVSFKSICNTSDNANFNFEALL
Protein: C2H2-like zinc finger protein (Putative C2H2-type zinc finger protein) (Q9ZU64)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MRRNIDYVSSTDYLPIKDNPHLTRVSFTQTITNRYSSIVPTNSLDAVQYDIELVKRAMDSKPNIWNPVFYPPNFLGKQCEILNPEPLNVIFPHQNSGDRQYLNMFSLSSKHNHDQNVFHEGRSSTKIPKPTMSIEKTTEYIDCEENEKSDDAQYDGRIHSLPYKKYGPYTCPKCNSIFDTSQKFAAHMSSHYKSETNKERAQRFRARNKRKYRKLNLEVYGESQKIKQEDGVHNDGRSDDKPIQHHKILFR
Protein: Tripartite motif-containing protein 10 (Hematopoietic RING finger 1) (RING finger protein 9) (Q9WUH5)
Organism: Mus musculus (Mouse)
Function: E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling. In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UDY6}.
Interaction partners:
- Glycophorin-A
- Kell blood group glycoprotein homolog
Sequence:
MASAPSVTSLADEVNCPICQGTLREPVTIDCGHNFCRGCLTRYCEIPGPESEESLSCPLCKEPFRPGSFRPNWQLANVVENIERLQLASTRGLEVEDACPEHGEKIYFFCEEDEAQLCVVCRETGQHGAHTVRFLEDAAGPYREQIQKCLVCLRKEREEIQETQSRENKRIQVLLTQVATKRQQVISQFAHLSQFLQQQQTALLAQLEGLDGDILKQQEEFDSLATGEICRFSTLIEELEEKNKRTARGLLTDIRSTLIRCETRKCRKPEAISPELGQRIRDFPQQAIPLRQEMKTFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHRRARFSYKWQNSPDTPQRFDRVTCVLAQCGFTGGRHTWMVNVDLAHGGSCTVGVVREDVRRKGELRLRPEEGIWAVRLAWGFVSALGSFPTRLALEEQPRKVQVSLDYEVGWITFVNAVTQEHIYTFTASFTQKIFPLFGLWGRGSSFSLSCQEGAVSLL
Protein: Small ribosomal subunit protein uS7B (40S ribosomal protein S5b) (Q9VFE4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL6
- 40S ribosomal protein S27
- Small ribosomal subunit protein uS14
- Ubiquitin-ribosomal protein eS31 fusion protein
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein eS19A
- Small ribosomal subunit protein uS2
Sequence:
MSEEVVESSSQEASQVIPQEQEDWADDVVTTMPAQEVTEWPEIKLFGRWACDDISISDISLQDYIAVKEKFARYLPHSAGRYAAKRFRKAQCPIVERLTSGLMMKGRSNGKKLLACRIVKHAFEIIHLLTSENPLQVTVNAIVNSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLICTGAREAAFRNIKTVAECLADELINAAKGSSNSYAIKKKDELERVAKSNR
Protein: Methyltransferase domain-containing protein (Q57XQ9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSKYANPDYWEERYRSNDTTFDWYLTFDNLEPVLRPMLQPAEQIHVLVVGCGNSRLSPCMYEHLNVRKITNVDVSPTVISQMTRRYKGMDEMRWICCDLIHTAPDKLLTLLCPEDALFDFVIDKGLVDATLGGSNSFHNLYTLTKNLARVMKNGGRFLSVSYGAPETRIDHFRRRKLNFDVEHRTIEKSVFASGAAPTGSYHVYIMTKLGERQAVTAGAADDGALSGDTDDDDDFYDRFMTKANTTSADAARFD
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (A1L1I5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQIPLLNHKRSEKQEKAQHTVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHLQNLENSAFTADRHRKRKLLENSSLNSKLLKVNGSTAAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDSNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSANNKCCINGASTVVTTIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVSDAVPSVRVCLHVSSQF
Protein: Matrix Gla protein (MGP) (Q800Y2)
Organism: Argyrosomus regius (Meagre)
Function: Associates with the organic matrix of calcified cartilage.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MRSLLQFLALSAAIALCVCYESHESSESAEDLFVPPQQANSFMTPQRGNAYSPPRGNGNNFNLMRTVKSPAERRAETCEDYSPCRFYAYRHGFQQAYQRYFGSGTHPQQRPAAAARRY
Protein: Metal-ion transporter, putative (Q584K9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Vacuolar iron transporter 1
Sequence:
MVEKPREQHQLLPVRAGRATGYSATAVEVTTSTPHSLMSKSGGGRQAHVEPTEMRRRRESKVLLSALLFCFVFMSVEFVFGVLAHSLALLTDASHLLIDVGAYAMSVVSLCTASRSSCGKYNYGWHRAEVIGTLVSVFSIWALVVWIVMEGLDRSWTVLKCSRIHAMLATTAQQYKRNNSTSYYGFGNISQHPTVDKDGALTEATHMEMCTSIDSPIMVVVGVLGMVVNIVCTAILYFGGSHGHSHFGGSHHHSHSGNGEEEDSLCEENTEHNHSHDHGHGYGHSGSEGEGHDHSHSHSGRGFAVHAALLHALGDCVQSLGVILAGIFIYVANRYSYGVPSYRYSIYNLADPLCSLLFAVITLNMTRPLLRDLLGILMESTPPGINYSELLSALRSIKGVEGVHDLHVWSIASDYAALSVHLEADDKDAALQKAQEVCKRFGITHTTIQVDTVENGAGLCHSTCGTV
Protein: (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) (F4JFV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
Sequence:
MEITNVTEYDAIAKAKLPKMVYDYYASGAEDQWTLQENRNAFARILFRPRILIDVNKIDMATTVLGFKISMPIMVAPTAFQKMAHPDGEYATARAASAAGTIMTLSSWATSSVEEVASTGPGIRFFQLYVYKNRKVVEQLVRRAEKAGFKAIALTVDTPRLGRRESDIKNRFTLPPNLTLKNFEGLDLGKMDEASIDQIANDSGLASYVAGQIDRTLSWKDIQWLQTITNMPILVKGVLTGEDARIAIQAGAAGIIVSNHGARQLDYVPATISALEEVVKATQGRVPVFLDGGVRRGTDVFKALALGASGIFIGRPVVFALAAEGEAGVKKVLQMLRDEFELTMALSGCRSLSEITRNHIVTEWDTPRHLPRL
Protein: Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (Type-II keratin Kb1) (P04104)
Organism: Mus musculus (Mouse)
Function: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P04264}. Cytoplasm {ECO:0000250|UniProtKB:P04264}.
Interaction partners:
- Keratin, type I cytoskeletal 10
- Filaggrin
- Loricrin
- Coagulation factor XII
- Desmoglein-1-alpha
- Keratin, type II cytoskeletal 1b
- Involucrin
Sequence:
MSLQCSSRSLCRGGGGSRNFSSGSAGLVSFQRRSTSSSMRRSGGGGGGRFSGGGFCGSSGSGFGSKSLMNLGGGRSISKSVAGGGGSFCGGFGGGSYGGGGFGGGSYGGGGFGGGSFGGGGFGGSGFGGGLGGGGGFGSGGGFGGGRFGSMGPVCPPGGIQEVTINQSLLQPLNVEVDPQIQKVKSQEREQIKSLNDKFASFIDKVRFLEQQNQVLQTKWELLQQVDTTTRTQNLDPFFENYISILRRKVDSLKSDQSRMDSELKNMQDLVEEYRTKYEDEINKRTNAENEFVTIKKDVDSAYMTKVELQAKADALQQDIDFFSALYQMEMSQMQTQISETNVVLSMDNNRSLDLDGIISEVKAQYDSICQRSKAEAETFYQSKYEELQITAGKHGDSVRNTKMEISELNRMIQRLRSEIDGCKKQISQIQQNINDAEQRGEKALKDAQNKLNEIEDALSQCKEDLARLLRDFQELMNTKLALDMEIATYKKLLEGEEIRMSGECTPNVSVSVSTSHTSMSGSSSRGGGSGGGRYGGGGSYGGGSGGGSYGGSSGGGGSGGSYGGGSGGGSYGGGSGGGSSGSHRGGSGGGGGSSGGSYGGSSGGGRGGSSSGGGGVKSSGSSTVKFVSTSYSRGTK
Protein: Neurexin-4 (Neurexin IV) (Q94887)
Organism: Drosophila melanogaster (Fruit fly)
Function: Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20935638}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, septate junction {ECO:0000269|PubMed:20935638}.
Interaction partners:
- Neuroglian
- Contactin
- Sinuous
- GH03113p
- Sodium/potassium-transporting ATPase subunit alpha
- Protein 4.1 homolog
- Lachesin
- Sodium/potassium-transporting ATPase subunit beta-2
- L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
- Kune-kune
Sequence:
MRPPRSNTKAAFSSLQFGLLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPLMERAVLTATSSLTERGPDKARLNGNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLHHDFYSGGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNIDQRPMTTTKSMQVATGAQYYIAGGKDKNGFVGCMRLISVDGNYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPGPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFRSTIAENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGKNESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPVTHPPIEIETRPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHRHKGDYLTHEDQGADGADDPDDAVLHSTTGHQVRKRTEIFI
Protein: Protein Wnt-5b (Q9H1J7)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Frizzled-3
- Tyrosine-protein kinase RYK
- Frizzled-4
- Frizzled-6
- Frizzled-2
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-8
- Protein Wnt-5a
- Frizzled-9
- Frizzled-7
Sequence:
MPSLLLLFTAALLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMAYIGEGAKTGIKECQHQFRQRRWNCSTADNASVFGRVMQIGSRETAFTHAVSAAGVVNAISRACREGELSTCGCSRTARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRVLMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRVTRKGRLELVNSRFTQPTPEDLVYVDPSPDYCLRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYNQFKSVQVERCHCKFHWCCFVRCKKCTEIVDQYICK
Protein: Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) (Q62698)
Organism: Rattus norvegicus (Rat)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O43237}.
Interaction partners:
- Cytoplasmic dynein 1 heavy chain 1
- Cytoplasmic dynein 1 intermediate chain 2
- Cytoplasmic dynein 1 intermediate chain 1
- Cytoplasmic dynein 1 light intermediate chain 1
- Dynein light chain roadblock-type 1
- Dynactin subunit 6
- Dynein light chain 2, cytoplasmic
- Dynein light chain 1, cytoplasmic
- Cytoplasmic dynein 2 light intermediate chain 1
- Cytoplasmic dynein 2 heavy chain 1
Sequence:
MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLRETLVIFVADMSRPWTIMESLQKWASVLREHIDKMKIPPEEMRDLERKFMKDFQDYIEPEEGCQGSPQRRGPLTSGSDEDNVALPLGDNVLTHNLGIPVLVVCTKCDAVSILEKEHDYRDEHLDFIQAHLRGFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTIPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQESPARGPSGSPRTQGRGGPASVPSASPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPSAGGVQSTAKKSGTEGEPQSFRSLTEQCCQTGQKTVLSNVQEELDRMTRKPDSMVTNSSTENEA