wanglab/gogpt-training-data huggingface dataset:
Protein: Nucleobase transporter (Q4QH25)
Organism: Leishmania major
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSKLPQAAMLGTSLVVGVSMVMGPKAINSAPSFMLEYYKYLAGNKAAEALSPVFWRNILNFYTVVTMVAQAIHEPTNMTSFMCRFSLLFRLEVSCVLMMIELLVILIMPHTHAPEYGAIAAMMIVAYVGGAARAYFENTGYALFGPCPPIMMTGMLVGSAVSGSVVSVLQITLKASMSDTYSAVLTQSLIYFCLAIGVIFLSGLFLMILPYNSYARRYVAEFRSSRGLWANIYCPRKVVKETSDDGACGKTGAAGLQDRAACRYLADSDSEKKAEMLLETEHGKVAASGNRACHHLSLLYDDRFFTRERLEAEPTQEFALEPGSHDGAAVNATQTGACDCAHSQMTSGEVSKEVVTQKTAELERDNNDLPAAADRMPTTAELLQEVRLWPVIKKIYPMMIACFLTFCITYLVYPGIIVAVDSADGWFTTLTIAAYNFSDLVGRLLTLWRRLWPSRKVILIASITRIIFIPLLVLCAVHKIPSKAAAYVFTVIMGLSNGFVGSLSMIYSPATPSLSTDGERAMAGQLTGACLLIGCAVGSLIQLAEVLPFA
Protein: Myb family transcription factor PHL5 (Protein PHR1-LIKE 5) (Q0WVU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- At5g05790
- Transcription factor bHLH114
Sequence:
MMDNINFEFSNASQGSRLQLQQQPPQPFNLQDLNMIQYNQPSSPWTTETFSGLTPYDCTANQSFPVQCSSSKPYPSSFHPYHHQSSDSPSLDQSVSMIPMQPLPDQYMKPLYQRSCSNDFAATNASSASYSLSFEASHDPQELCRRTYSNSNVTHLNFTSSQHQPKQSHPRFSSPPSFSIHGGSMAPNCVNKTRIRWTQDLHEKFVECVNRLGGADKATPKAILKRMDSDGLTIFHVKSHLQKYRIAKYMPESQEGKFEKRACAKELSQLDTRTGVQIKEALQLQLDVQRHLHEQLEIQRNLQLRIEEQGKQLKMMMEQQQKNKESLLKKLPDAEASLSLLDPHIHSPPSPFLVHDAEALMLTSYEDTQLQSTKS
Protein: WT1 transcription factor (H0YED9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MEKGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
Protein: DNA repair protein RAD16 (EC 3.6.4.-) (ATP-dependent helicase RAD16) (P31244)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. Involved in differential repair of DNA after UV damage. Will repair preferentially the MAT-alpha locus compared with the HML-alpha locus.
Subcellular location: Nucleus.
Interaction partners:
- DNA repair protein RAD7
- DNA repair protein RAD4
- UV excision repair protein RAD23
- DNA repair protein RAD2
- Elongin-C
- DNA repair protein RAD14
- DNA repair protein RAD10
- DNA repair protein RAD1
- ARS-binding factor 1
- Cullin-3
Sequence:
MQEGGFIRRRRTRSTKKSVNYNELSDDDTAVKNSKTLQLKGNSENVNDSQDEEYRDDATLVKSPDDDDKDFIIDLTGSDKERTATDENTHAIKNDNDEIIEIKEERDVSDDDEPLTKKRKTTARKKKKKTSTKKKSPKVTPYERNTLRLYEHHPELRNVFTDLKNAPPYVPQRSKQPDGMTIKLLPFQLEGLHWLISQEESIYAGGVLADEMGMGKTIQTIALLMNDLTKSPSLVVAPTVALMQWKNEIEQHTKGQLKIYIYHGASRTTDIKDLQGYDVVLTTYAVLESVFRKQNYGFRRKNGLFKQPSVLHNIDFYRVILDEAHNIKDRQSNTARAVNNLKTQKRWCLSGTPLQNRIGEMYSLIRFLNINPFTKYFCTKCDCASKDWKFTDRMHCDHCSHVIMQHTNFFNHFMLKNIQKFGVEGPGLESFNNIQTLLKNIMLRRTKVERADDLGLPPRIVTVRRDFFNEEEKDLYRSLYTDSKRKYNSFVEEGVVLNNYANIFTLITRMRQLADHPDLVLKRLNNFPGDDIGVVICQLCNDEAEEPIESKCHHKFCRLCIKEYVESFMENNNKLTCPVCHIGLSIDLSQPALEVDLDSFKKQSIVSRLNMSGKWQSSTKIEALVEELYKLRSNKRTIKSIVFSQFTSMLDLVEWRLKRAGFQTVKLQGSMSPTQRDETIKYFMNNIQCEVFLVSLKAGGVALNLCEASQVFILDPWWNPSVEWQSGDRVHRIGQYRPVKITRFCIEDSIEARIIELQEKKANMIHATINQDEAAISRLTPADLQFLFNN
Protein: Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (IL-12 subunit p40) (E9PU71)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU281113}.
Interaction partners:
- Interleukin-23 subunit alpha
- Interleukin-12 subunit alpha
- Interleukin-12 receptor subunit beta-1
- Interleukin-23 receptor
- Interleukin-12 receptor subunit beta-2
- Interleukin-2 receptor subunit alpha
- Interferon gamma
- Interferon gamma receptor 1
- Interferon alpha/beta receptor 1
- Interleukin-10
Sequence:
MCHQKLTFSWFAMVLLVSPLMAMWELEKDVYVVEVDWRPDAPGETVTLTCDSPEEDDITWTSDQRRGVIGSGKTLTITVREFLDAGQYTCHRGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVHRNTDLKFNIKSSSSSPESRAVTCGAASLSAEKVTLNQRDYEKYSVACQEDVTCPTAEETLPIELVVEAQQQNKYENYSTSFFIRDIIKPDPPKNLQVKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKTKETEEECNQKGAFLVEKTSAEVQCKGANICVQAQDRYYNSSCSKWTCVPCRGRS
Protein: E3 ubiquitin-protein ligase RNF26 (EC 2.3.2.27) (RING finger protein 26) (Q9BY78)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25254379, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:32614325}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Endonuclease domain-containing 1 protein
- Transmembrane protein 33
- Ubiquitin carboxyl-terminal hydrolase 15
- E3 ubiquitin-protein ligase RNF5
- Transmembrane protein 43
Sequence:
MEAVYLVVNGLGLVLDVLTLVLDLNFLLVSSLLASLAWLLAFVYNLPHTVLTSLLHLGRGVLLSLLALIEAVVRFTCGGLQALCTLLYSCCSGLESLKLLGHLASHGALRSREILHRGVLNVVSSGHALLRQACDICAIAMSLVAYVINSLVNICLIGTQNLFSLVLALWDAVTGPLWRMTDVVAAFLAHISSSAVAMAILLWTPCQLALELLASAARLLASFVLVNLTGLVLLACVLAVTVTVLHPDFTLRLATQALSQLHARPSYHRLREDVMRLSRLALGSEAWRRVWSRSLQLASWPNRGGAPGAPQGDPMRVFSVRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKKCVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCRRGILQTLNVYL
Protein: Ribonuclease VapC3 (RNase VapC3) (EC 3.1.-.-) (Toxin VapC3) (P9WFB7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB3.
Interaction partners:
- Antitoxin VapB3
- Ribonuclease VapC47
- Ribonuclease VapC9
- Ribonuclease VapC30
- Putative toxin Rv3098A/RVBD_3098A
- Ribonuclease VapC49
Sequence:
MRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQVPVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG
Protein: Bidirectional sugar transporter NEC1 (NEC1) (Q9FPN0)
Organism: Petunia hybrida (Petunia)
Function: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane. Promotes the formation of phloem bundles in mid-veins. Probably involved in the development of stomium cells that control anther opening time. Required for pollen viability.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8L9J7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
Interaction partners:
Sequence:
MAQLRADDLSFIFGLLGNIVSFMVFLAPVPTFYKIYKRKSSEGYQAIPYMVALFSAGLLLYYAYLRKNAYLIVSINGFGCAIELTYISLFLFYAPRKSKIFTGWLMLLELGALGMVMPITYLLAEGSHRVMIVGWICAAINVAVFAAPLSIMRQVIKTKSVEFMPFTLSLFLTLCATMWFFYGFFKKDFYIAFPNILGFLFGIVQMLLYFVYKDSKRIDDEKSDPVREATKSKEGVEIIINIEDDNSDNALQSMEKDFSRLRTSK
Protein: GH15759p (Sex-specific enzyme 2, isoform A) (Sex-specific enzyme 2, isoform B (EC 3.1.1.3)) (Q9VEY9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Probable cytochrome P450 4d21
Sequence:
MGSLTGMHISHWLLWTCLLLLGAAGTDASVDYFAYAPGKCEVSISDVIQGMITTEAGVILGRPRPSQTKLLRYDLYTPLNPEERQLLRPGDLTMLRNSHFNPKWPVRVSIHGWAGKSVTCSNAAIKDAYLSRGNYNVIILDWSRQSLDISYPRVSKQLPSIAANVAKMLRFLHDNTGVPYEQIYMIGHSAGSHISGLTGKLLRPHRLGAIFALDPAGLTQLSLGPEERLDVNDALYVESIHTDLTLLGNPSTKLSHASFFANWGLGQPHCPNATATEFDFVCDHFAAMFYFAESVRQPKSFAALRCSSAKSVLSATCNCNVGGSEKYAVNTCTGNEFMGGEPAVPKRGIFYLSTRPQSPYGTSDGLVHIKRPRPSTIRETANRRSIG
Protein: Nuclear receptor subfamily 2 group F member 6 (COUPg) (Ovalbumin upstream promoter gamma nuclear receptor) (V-erbA-related protein 2) (EAR-2) (O09017)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC) (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MAMVTGGWGGPGGDTNGVDKAGGSYPRATEDDSASPPGATSDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRTIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQPGPIPHALPGPAACSPPGAAGVEPFAGPPVSELIAQLLRAEPYPAAGRFGGGGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVGLLRLSWSELFVLNAAQAPVPLHTAPLLAAAGLHAGPMAAERAVAFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSG
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (A0A0G2JW59)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000311}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000311}.
Interaction partners:
- Fms-related tyrosine kinase 3 ligand
- Signal transducer and activator of transcription 3
- CCAAT/enhancer-binding protein alpha
- Growth factor receptor-bound protein 2
- Signal transducer and activator of transcription 5A
- Transcription factor PU.1
- Kit ligand
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 3-kinase regulatory subunit gamma
Sequence:
MRALARRSDRLPLLVVLSVMILETVTNQDLPVIKCVLIIHKNNGSAAGKSSSHVMVPESPEDLRCAPKHRSEGVVYEAVTVEVAQSASFTLQVQLTTPGDVSCLWVFKHSSLGCQPHFDLQNRRIVSMTILNVTETQAGEYLLHIQSEATNHTVLFTVNVRDTQLYVLRRPSFRKMENQDALLCVSEGVPEPTVEWVVCSSHRDSCREEGSAVVKKEEKVLHELFETDIRCCARNALGRECTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHVNHGFGLTWELGNKVLEEGSYFEMSSYSTNRSMIRILLAFVSSVGRNNTGYYTCSSSKHPSQTALVTILEKGFINATSSQEEYEIDPYEKFCFSVRFKAYPQIRCKWTFSQTSFPCEQSGLEDGYSISKFCDHKNNPGEYIFHGENDDAQFTKMFILNIRRKPQVLANASASQASCFSDGYPLPNWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGRGFLVKCCAYNSMGTSCETILLNSPGPFLFIQDNISFYATIGLCPPFIVVLTVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYIDFRDYEYDLKWEFPRENLEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADRCEREALMAELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCHGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHSNSSMPGSREVQIYPPVDQVSGFNGNSIHSEDEIEYENQKRLEEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEEIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEAAMYQNMGGDVPLEHPAIYQNRRPASREAGSEPPSPQVQEKTHRERS
Protein: Angiogenin-2 (EC 3.1.27.-) (Angiogenin-related protein) (Q64438)
Organism: Mus musculus (Mouse)
Function: Has ribonuclease activity (in vitro). Seems to lack angiogenic activity.
Subcellular location: Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q3TMQ6}. Secreted {ECO:0000250|UniProtKB:P10152}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P03950}. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity). {ECO:0000250|UniProtKB:P03950}.
Interaction partners:
- Angiogenin-4
- Angiogenin
- Ribonuclease 4
- Angiopoietin-1 receptor
Sequence:
MAMSPGPLFLVFLLGLVVIPPTLSQDDSRYTKFLTQHYDAKPKGRDDRYCESMMVKRKLTSFCKDVNTFIHDTKNNIKAICGKKGSPYGRNLRISKSHFQVTTCTHKGRSPRPPCRYRASKGFRYIIIGCENGWPVHFDESFISP
Protein: inositol-polyphosphate 5-phosphatase (EC 3.1.3.56) (Q8IGM4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MESAQEDASSTDVFLVTANVGSLFEDPERLLQLWLSEFLAKIAVAQPRFLALHLQEVGGKTYEKSMEYVQEFIRCLCDAPEMGDFTCVHIFMDEDFKSAEHFTALGSLYFVHKDVASLKIWNFLTHSWEESLQDVKDKHIYSGNIETIATKEKSKFPQHFFPECKWSRKGFMRTRWEINGTVIDLVNIHLFHDASNLAACENFPSVYCKTRRRALVHTIERFHLDEQNGTVPFFLFGDFNFRCDTEGVVKELTENLTPHRVQNVKNENDKIHYRNSTGNNVLTVGKKEFSHADHQLKFKEDWLKKFDRELEPLKDVLVEYPIKFVPSYPFEEDPEMPTDYMSTRCPAWCDRILMSPQVNEIIQSDDWTYGMIGEAVCMGDHKPVYLTVRLKPNKGTYRSCDCNYTNTYAKPNNISTSPLPAVKLKYCPYSNKLFEDIATSSKLIVDTEARNMYNSLKISQDAEASRTTSSNFPNISINIIDSDNICMCLCAHLSSNSLLQLDGCDRTGEAICPMCRNIIKRQPVAHRYKLLSKRLMISQDIIINRIDSQHLSTDSERQYEDPYTPESTESHSPYPEVTSSCTSTSSSSRSPFERRLATDRLATESKAGDSDISPCPEVRDLVAEKPARGTVTPGQLKSRLETLKRLSIKDEAQDEGEDAVDEAGAGGDVEHVGAVCPPNAAPMRPKRRSKVIPMCCTIN
Protein: Pyridoxamine 5'-phosphate oxidase C1952.08c homolog (PNP/PMP oxidase C1952.08c homolog) (PNPOx C1952.08c homolog) (Q9UUK0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Lipoyl synthase, mitochondrial
- Putative lipoate-protein ligase A
Sequence:
MASKVDSSHEFPSQIKRCLSSSKYIQLATCFHDQPHSSLMTFTYLPAGSAAPYEVEDCIILSTGENSKKYFNISSNPRVSLLVHDWTTNRQETDPDASSLYTLLYKMNQAQFSNTSVTLNGLATVLPKNSKEEEFFREKHLNTNDKGNTKQYVEGEDMRIIKIKLESARICDQRLNNVQKWNARGDETPF
Protein: Hexokinase-1 (EC 2.7.1.1) (Q09756)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the phosphorylation of hexose (six-carbon sugars) to hexose 6-phosphate. Phosphorylates D-fructose, D-mannose and, to a lower extent, D-glucose. Compared to hxk2, has low affinity for D-glucose.
Interaction partners:
- Glucose-6-phosphate isomerase
- ATP-dependent 6-phosphofructokinase
- Hexokinase-2
- Invertase
- Putative invertase
- Phosphoglucomutase
- Mannose-6-phosphate isomerase
- Phosphomannomutase
- Glucosamine 6-phosphate N-acetyltransferase
- Probable glutamine--fructose-6-phosphate aminotransferase
Sequence:
MSLHDAYHWPSRTPSRKGSNIKLNKTLQDHLDELEEQFTIPTELLHRVTDRFVSELYKGLTTNPGDVPMVPTWIIGTPDGNEHGSYLALDLGGTNLRVCAVEVQGNGKFDITQSKYRLPQELKVGTREALFDYIADCIKKFVEEVHPGKSQNLEIGFTFSYPCVQRSINDASLVAWTKGFDIDGVEGESVGPLLSAALKRVGCNNVRLNAILSDTTGTLVASNYASPGTEIGVIFGTGCNACYIEKFSEIPKLHKYDFPEDMNMIINCEWCDFDNQHVVLPRTKYDVAIDEESPRPGLQTYEKMIAGCYLGDILRRILLDLYEQGALFNGQDVTKIRDPLAMDTSVLSAIEVDPFENLDETQTLFEETYGLKTTEEERQFIRRACELIGTRSARLSACGVCALVRKMNKPSMIVGTDGSVYNLYPRFKDRLAQAFKDILGEEIGSKVVTIPAEDGSGVGAALVSALEAKGKALTSDILAEHLKN
Protein: Pleiotropic regulator 1 (Q6DRE2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MTEDVQKHSVHTLVFRSLKRTHDMFVADHAKPIAQDEQSFKVKMAAKMRAEYKAVLHMPVLKEGREKGSLHTSDPYGQSAYPLPDTTPEYLVTGTHPYPSAPGVVLTADTQMLKMPSEMGVHSMALALPPSQARQEASRTAASVAEIHRHAGGAERSHPPQHALSLMEGGTRTLVPRKAPTMPKPQWHPPWKLYRVISGHLGWVRSIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVAVSNRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYDLDLHPTIDVLVTCSRDATARVWDIRTKANVHTLSGHTNTVATVKCQSAEPQVVTGSHDTTIRLWDLVAGKTRATLTNHKKSVRALVLHPRQYTFASGSPDNIKQWKFPDGNFIQNLSGHNAIINTLAVNSDGVLVSGADNGTIHMWDWRTGYNFQRIHAAVQPGSLDSESGIFSCVFDQSESRLITAEADKTIKVYKEDDTATEESHPVNWKPEILKRKRF
Protein: aromatase (EC 1.14.14.14) (Cytochrome P-450AROM) (Estrogen synthase) (Q5U870)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MMEHVVKDAVNIGAVVQGTLLLLTGTLMLILLHRIFGVKNWRNQSALPGPGWWLGLGPVLSYSRFLWMGIGTACNYYNEKYGSIARVWINGEETVILSKSSAVYHVLKSNNYTGRFASAKGLQCIGMFEQGIIFNSNIAKWKKVRTYFTKALTGPGLQKSVEVCVSATNRQLDVLQEFTDASGHVDVLNLLRCIVVDVSNRLFLRIPLNEKELLIKIHRYFSTWQTVLIQPDIFFKLDFVYRKYHLAAKELQDEMGKLVEQKRQAINNTEKLDEMDFATELIFAQNHDELSVDDVRQCVLEMVIAAPDTLSISLFFMLLLLKQNSAVEEQIVQEIQSQIGSRDVESADLQKLNVLERFIKESLRYHPVVDFIMRQSLEDDYIDGYRVAKGTNLILNIGRMHKTEFFKKPNEFSLENFENTVPSRYFQPFGCGPRACVGKHIAMVMTKAILVTMLSRFTVCPRHGCTISTIRQTNNLSMQPVEEDPDCLAMRFIPRAQNSNGETADNRTSKE
Protein: 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) (Q8T0H4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAIMEHAYYASFGYQVTSFYAASSRYGNPEQLKRMIDVAHSHGLFVLLDVVHSHASKNVQDGLNQFDGTNSCFFHDGARGEHSLWDSRLFNYVEYEVLRFLLSNLRWWHDEYNFDGYRFDGVTSMLYHSRGIGEGFSGDYNEYFGLNVDTDALNYLGLANHLLHTIDSRIITIAEDVSGMPTLCRPVSEGGIGFDYRLGMAIPDKWIELLKEQSDDEWDMGNLVHTLTNRRWMENTVAYAESHDQALVGDKTIAFWLMDKEMYTHMSTLSDSSVIIDRGLALHKMIRLITHALGGEAYLNFMGNEFGHPEWLDFPRVGNNDSYHYARRQWNLVDDDLLKYKYLNEFDRAMNEAEERYGWLHSGPAWVSWKHEGDKIIAFERAGLVFVFNFHPQQSFTGYRVGTNWAGTYQAVLSSDDPLFGGHNRIDANCKHPSNPEGYAGRSNFIEVYTPSRTAVVYARVSD
Protein: Zyx102 protein (Zyx102.44 isoform) (Zyxin, isoform B) (Zyxin, isoform L) (Q9N675)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Vinculin
- Protein enabled
- Unc-112-related protein
- Rhea, isoform B
- Protein crumbs
- Protein limb expression 1 homolog
- Filamin-A
- Atypical protein kinase C
- Moesin/ezrin/radixin homolog 1
- Patj homolog
Sequence:
MESVAQQLRELSLPKGDTGSPLVCIGHGKVAKLVAKISNNQNASVKRRLDIPPKPPIKYNEMPQVPSSRQVLCSREPLYSQPLIGVEKTMRGHMPFRKYLSSEFGVADTQINRKTTLDNPAILEQQLEALAYHKLQMEKKGLLGVQAKPTQPLNSFTKPLSKTLSKSLIYSNLGSVRKEIETLELLTDETKISASTYSNVNETAMDSSHSSTQKMLSVCTNFISDNEKDELPPPPSPESAVSSSYSELRHATLEFNKPIDYLQNNQTTNPLQIYANQYAMQHDATGKSSSTYDSIYEPINPRPCVADTLPRESYNLHNSYVNDNNPNISHEYNISNSIEANQTLYIHGNARTTFYDVNSIHRNDKEGLKNYISIPTEPVQELENYGRCVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLEKCSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCVCKQPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLCKSCNAKRVQALTNRMTSEH
Protein: Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4) (O70437)
Organism: Rattus norvegicus (Rat)
Function: Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q13485}. Nucleus {ECO:0000250|UniProtKB:Q13485}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation. {ECO:0000250|UniProtKB:Q13485}.
Interaction partners:
- Mothers against decapentaplegic homolog 3
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 1
- Mothers against decapentaplegic homolog 9
- Mothers against decapentaplegic homolog 5
- Ski oncogene
- Lymphoid enhancer-binding factor 1
- SKI-like proto-oncogene
- Catenin beta-1
- Forkhead box protein H1
Sequence:
MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPPSMLVKDEYVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETYSAPALLAPSESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
Protein: Protein NPG1 (NO POLLEN GERMINATION 1) (Q8GZN1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Calmodulin-binding protein essential for pollen germination, but not necessary for microsporogenesis or gametogenesis.
Interaction partners:
- Hyccin
- At5g64090
- Phosphatidylinositol 4-kinase alpha 1
- Phosphatidylinositol 4-kinase alpha 2
- Uncharacterized protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- Uncharacterized protein
- AT3g56990/F24I3_70
- BTB/POZ domain-containing protein SETH6
Sequence:
MLGNQSADFSEKGEDEIVRQLCANGICMKTTEVEAKLDEGNIQEAESSLREGLSLNFEEARALLGRLEYQRGNLEGALRVFEGIDLQAAIQRLQVSVPLEKPATKKNRPREPQQSVSQHAANLVLEAIYLKAKSLQKLGRITEAAHECKSVLDSVEKIFQQGIPDAQVDNKLQETVSHAVELLPALWKESGDYQEAISAYRRALLSQWNLDNDCCARIQKDFAVFLLHSGVEASPPSLGSQIEGSYIPRNNIEEAILLLMILLKKFNLGKAKWDPSVFEHLTFALSLCSQTAVLAKQLEEVMPGVFSRIERWNTLALSYSAAGQNSAAVNLLRKSLHKHEQPDDLVALLLAAKLCSEEPSLAAEGTGYAQRAINNAQGMDEHLKGVGLRMLGLCLGKQAKVPTSDFERSRLQSESLKALDGAIAFEHNNPDLIFELGVQYAEQRNLKAASRYAKEFIDATGGSVLKGWRFLALVLSAQQRFSEAEVVTDAALDETAKWDQGPLLRLKAKLKISQSNPTEAVETYRYLLALVQAQRKSFGPLRTLSQMEEDKVNEFEVWHGLAYLYSSLSHWNDVEVCLKKAGELKQYSASMLHTEGRMWEGRKEFKPALAAFLDGLLLDGSSVPCKVAVGALLSERGKDHQPTLPVARSLLSDALRIDPTNRKAWYYLGMVHKSDGRIADATDCFQAASMLEESDPIESFSTIL
Protein: Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C) (Q7TS72)
Organism: Mus musculus (Mouse)
Function: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (By similarity). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96DU7}. Cytoplasm {ECO:0000250|UniProtKB:Q96DU7}. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. {ECO:0000250|UniProtKB:Q80ZG2}.
Interaction partners:
- Inositol polyphosphate multikinase
- Inositol polyphosphate-5-phosphatase A.
- Calmodulin-1
- Inositol-tetrakisphosphate 1-kinase
- Inositol polyphosphate 5-phosphatase K
- Kinase
- Inositol-trisphosphate 3-kinase A
- Multiple inositol polyphosphate phosphatase 1
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Sequence:
MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGPGAGGPTGRPEGGGPRAWIEESSLHSEAERTDLEPAPCPNGPQAESCGDGHAECEAAGLVVASEKPRQNKELDGSNLQTHPRRNSPLVEMEMAGSWTDGFRTDLHRSDLQSRPKRASLCTQPGFDESWTELDRSDMWQTLPERDNKPRVDNLRTHHGVSKLQTHPVCLSPESSADNSGKELSADASRTPHDTDGFWIESQTDDSLKGPSTQTACRQPGSDGFSSKDTESALTQPGTDGLRDDSVLGESNGNDPLDLSEPGELVTNLCSHLECSSLCPVPRLIITPETPEPEAQPVGPQSRIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRAGSKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPAYYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAITKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDLGILRKYVARLEDLRETLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWTEGNREDGYLWGLDNLICLLQGLAQS