wanglab/gogpt-training-data huggingface dataset:
Protein: Corticoliberin (Corticotropin-releasing factor) (Corticotropin-releasing hormone) (F7E8Q2)
Organism: Macaca mulatta (Rhesus macaque)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Corticotropin-releasing factor receptor 2
- Corticotropin-releasing factor receptor 1
- Urocortin
- Urocortin 3
- Urocortin 2
- Corticotropin-releasing factor-binding protein
- Pro-opiomelanocortin
- Pro-neuropeptide Y
- Pro-thyrotropin-releasing hormone
- Glucocorticoid receptor
Sequence:
MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQYPQPLDFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQAAANFFRVLLQQLLLPRRSLDSPAALAERGAENALGGHQEATERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
Protein: Small ribosomal subunit protein eS10 (40S ribosomal protein S10) (A0A2R8YFH6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFVSIFLFVFHEPSLVLASVWLLCKLWGCHIVWVGPVNQFPPPTFFQIPNFTLSCSMQTFVNT
Protein: Mushroom body large-type Kenyon cell-specific protein 1 (Q95YM8)
Organism: Apis mellifera (Honeybee)
Function: Transcriptional activator which binds to the consensus sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in higher-order sensory processing.
Subcellular location: Nucleus {ECO:0000255}.
Interaction partners:
Sequence:
MADCPYARCIQERRHIRRELLRWTKNMVFVVGLERVAEELMGRRRWKQYQDTLYSGTRSSESLTAQAHHRLYPAFSSSCDPVPGNLEQIGSRPLHPPASSTSLPATITTTTTTTTTTTATAAATATTTATGLIKQETLQRHHHLQNHHHHLQSTAVQDHHRPYQQQQQQQQRQQQRQEERRLRPDEIKVEVGEDEFANGGAARDESKAGSTDASTPATVTTTGATTTLPAASATGTGPATPSAVVATSNATAAMTTGTTTIPTRRLRKRRQNDGEGADDRDDDEENEEEEDGRGQSEAEKRLKLDEDADGAVSPLRREKDRGSREYPTSNATDTDGTKERTEEVALDRTPVTQGLLRVKKEEELQEAPSCGGGPTILTTPGLDSDGIRLPCREVEAAATARNVVAPFLIGSRRTSPPPEDWKPLDKCYFCLDGKLPHDDQPPLSPQSDSSSSSRSAESPMSVQVDPMAASVVAAALTGTYPTLLPQWCLPPREAPLVGVQPHQDSATPADQPLDLSAKPKNSQDNNISLLEQQKIPLRMTAGIDPKSIFNSGYRPKPRMSGPVAAVAAAAVAAAGVGGVPVVGAGGGRRAYTEEELQAALRDIQSGKLGTRRAAVIYGIPRSTLRNKVYKLAMERERDASLSSTHSHPHEPGAPATTITTITTTTTTTTTTTTTTTTPNTTQNASATTPPPQVDEVDDKELSGAEEEKEVEKALLKPLLSLEDLVRFSTLEGSGGDSLRTLLQRGQETGAEWPGLEHANIGPYIQKMIAAAAPFKGMETQDYRIPEVMRRLMSEDKRLSKSVNGDQSQPPHQQLHHHQSTHPQAQAQAQPQQQQQQQQQQPQQQQQQQQQQQQQQRGPMTNDDFNPNIEEEASDSAQGRAILKIPSYKPASTPGCSSKNGEPTSAAFAQGFATAASSPGLLERASPAFSGTSSPTNSLVGKTVAVNFRDVIAKSISVKFQEGQTVSGGGMGGCQPGGVVQSQQPIMTDPSPFKRGRYTPPQPANAQQGQAQAQAKPQSQEANKPKPATGGKGTRPKRGKYRNYDRDSLVEAVRAVQRGEMSVHRAGSYYGVPHSTLEYKVKERHLMRPRKRDQKQSDDKTKETSTVTAAAAATNIRPGTADNKPQLKPQKPFTSPGGIPGPNGIKMPSFMEGMPHLPFTPFNFWNPPPFMPSPFMAGAPNVPTILPEQYFATSRIRGLQEQQRNAAMVQQQQQQQQQQQQQQQQQQQQQQQQQHQAREREGVGAGIAETSAGTSNSRGAAQMSKVPRDVSEGIYDGSGANGSFLDNLIRSSLETGIPRDQRAMTEARNQQQQASSQQQIPESMRSKALIDQLCRNSRRTPVPRLAQDSSEDESYRGPSASGGRPVPERPERVPTVDLSPSPSDRGRNDDGSDRLTSPPTPLSISRAGSRDEDSTRDSTKLDRSSREREVHNGGQQEDRDRKTLTSAPQQPQQQQQQQQQQQQQQQQLNHYPDLHNLYAVPTDKKSACDSKLIVDHSSQKTQQQQPQQQQQQQQQQQPQQQSQQPQQQQPQPQQQQQQQQQQQPQQQQKEYGAVSGLVVQLQRGYNSGNNRSGEQANSQQQQQQQSGEPVIGMEDSVEQ
Protein: Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) (Q6VYH9)
Organism: Mus musculus (Mouse)
Function: Adapter protein involved in tyrosine kinase and CD28 signaling (By similarity). May be a modulator of the apoptotic response through its ability to affect mitochondrial stability.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15569688}. Mitochondrion {ECO:0000269|PubMed:15569688}.
Interaction partners:
Sequence:
MAEARRLPPPLPPRLDWFVHTQADLLAQSGIPEWFHGTISREAAENMLESQPLGTFLIRVSHSHVGYTLSYKAQTCCRHFMVKLSEDGTCAFAGDHMTHASLHALVTFHQQKPIRPFGELLTQACGQEDPANVDYEDLFLYSNALVQDAESQILRTEVQRSSCPPEEASERKPSTTTKGEFASASCSPKALFEDSGQKLWKNLRSLPQTSQRVKQRLTSHLLAMNLLGDARQVAQQHHSPVTRAFSWDSTSHSEDSCAATTSLQNPAEPQALRGREATFRDSRPASWRKAFSGVKAWRGKVVRALSAQEPVDFPEAQGWLPEEYLPPPPFAPGY
Protein: DNAation factor-related protein 3, isoform A (DNAation factor-related protein 3, isoform B) (RH09855p) (Q0E9B7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- DNAation factor-related protein 4
- DNAation factor-related protein 2, isoform B
- DNAation factor-related protein 1, isoform B
Sequence:
MTAMNADETKLAGMPQGAEEEQEPEREQKKESDGAAAAAGVQCDPDSRIVAPPPRQRTLTRTAELDADCEDIELDADDGLDDAADSITLELALSPHSSATPTPSPTTADEDFAQLDNSKPFKIKDITRNIRKAVVATTLSELRTKVSLKFERAQPAIHLDCDGTEVDDEEYFSTLEPNAELIAVFPGEQWRDPSDYNANLRRTSLDAQRLRSLVSKLQPNYMNDDDLDKLSNMDPNSLVDITGREPKDNEYSARSDAARLSTELSC
Protein: Long chain acyl-CoA synthetase 3 (EC 6.2.1.3) (Q9C7W4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate.
Interaction partners:
- Palmitoyl-acyl carrier protein thioesterase, chloroplastic
- Oleoyl-acyl carrier protein thioesterase 2, chloroplastic
- Oleoyl-acyl carrier protein thioesterase 1, chloroplastic
- Peroxisomal acyl-coenzyme A oxidase 1
- Putative peroxisomal acyl-coenzyme A oxidase 1.2
- Acyl-coenzyme A oxidase 2, peroxisomal
- Probable acyl-CoA dehydrogenase IBR3
- Acyl-coenzyme A oxidase 3, peroxisomal
- Acyl-coenzyme A oxidase 4, peroxisomal
- Putative acyl-coenzyme A oxidase At3g06690
Sequence:
MATGRYIVEVEKGKQGVDGGSPSVGPVYRSIYAKDGFPEPPDDLVSAWDIFRLSVEKSPNNPMLGRREIVDGKAGKYVWQTYKEVHNVVIKLGNSIRTIGVGKGDKCGIYGANSPEWIISMEACNAHGLYCVPLYDTLGAGAIEFIICHAEVSLAFAEENKISELLKTAPKSTKYLKYIVSFGEVTNNQRVEAERHRLTIYSWDQFLKLGEGKHYELPEKRRSDVCTIMYTSGTTGDPKGVLLTNESIIHLLEGVKKLLKTIDEELTSKDVYLSYLPLAHIFDRVIEELCIYEAASIGFWRGDVKILIEDIAALKPTVFCAVPRVLERIYTGLQQKLSDGGFVKKKLFNFAFKYKHKNMEKGQPHEQASPIADKIVFKKVKEGLGGNVRLILSGAAPLAAHIESFLRVVACAHVLQGYGLTESCGGTFVSIPNELSMLGTVGPPVPNVDIRLESVPEMGYDALASNPRGEICIRGKTLFSGYYKREDLTQEVFIDGWLHTGDVGEWQPDGAMKIIDRKKNIFKLSQGEYVAVENLENIYSHVAAIESIWVYGNSYESYLVAVVCPSKIQIEHWAKEHKVSGDFESICRNQKTKEFVLGEFNRVAKDKKLKGFELIKGVHLDTVPFDMERDLITPSYKMKRPQLLKYYQKEIDEMYKKNREVQLRV
Protein: No-mechanoreceptor potential A long isoform (Q9BMD5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRPRKGIHVLLTTLVVSLSLSKINGQTTCKNGLGRVLYERLPNQQLQGYDDDVVRDTAPPFRVLEKCQDLCLRDRSGSNNLVRTCTSFDFQPGSRITSFGGNSEYEESLCYLTSEQAGPEGIGSLMLVPNSVHFNEICLTSSRPERECPSRRYVFERHPRKKLKLPISDIKEITAANRSDCEDKCLNEFSFVCRSANFDSTMRSCTLSRFTRRTHPELMEDDPNSDYLENTCLNAERRCDGLAVFVKEENKRLGGPFEVDIFNNMTLEECQTMCLRAEKYFCRSVEFDDQSKQCILSEEDSISQKDDISISSSPTHHFYDLVCLDNQRANDYPDNSVTSHLFSSGRRPDTAFQRYRNSRLGGEFHSEITGRSLSECLDECLRQTSFQCRSAVYSDRFRTCRLSRYNQKDGMRIIYDADYDYYENLMLNVVGGGADGDGGGHGGSSDGKRPGDQSGSNWRQPNKHDDRYGSGGSSVGGGSHGGTGSGGSRLPPGEGVDYGRPYDRYPDIAGNEYDRNPYGGDRDRDRYPPDRYGSRYPTGGDGIGYNRPYDRFPDDYDRYPAGAGVNGDRDRERDRDRYPVVGDRDRYPGAVDRDRYPGVRDRXRYPEPYPPERYXDRYGDRRYPERERDRDRDRLPYRPLPYPGINDNSLPSDLPHTRPYPTDDDAPFRPYGYGGGRYGENRYEGRYPPRFPPSRERDPVGGYTGRDAPDSIFPDRRYRPSSMDSPRYPYLPDSRGPPGRYDDIVHSARRPEPDSAKRYPPAPIAPTGSSSKYASTPNRFPVGNDRYPIDIYKYGNRPGPNDLGRRPGLERPPPPFYDYDYEERYGDRYGPYDREYDGPPGRRPPSGGPYGRYDSPFNRPYGGNGLDDRPLPLPGLGLSHPPTPYGGGGAGHVGVGVGVNSGPPRPPITRCEESDNFKQIAARHKMRRHFVRRALIVPSLIQCERECIESRDFVCRSFNYRDSAASGYEDRDRDRDRDSPNCELSDRDSRELDIHDPGTFDASNYDFYERSIGRSDGECMDVTQTCNEEGMEFTIRTPEGFLGRIYTYGFYDRCFFRGNGGTVNVLRLSGPQGYPDCGTQRYGDTLTNIVVVQFSDNVQTSRDKRYNLTCIFRGPGEAVVSSGYIGAGSGSPIPIEYLPAENTLSSKVRLSILYQGRPTTTIAVGDPLTFRLEAQDGYNHVTDIFATNVVARDPYSGRSIQLIDRFGCPVDPFVFPELDKLRDGDTLEARFNAFKIPESNFLVFEATVRSCREGCQPAYCPGPAGRQEPSFGRRRRSLNTTEIPEPEALALEGSSQLEASTLDEVTVVNSTTVSATLGQVPLNETQLGEKTKETEEPEQVREMIEVFETREEIEKESYPRKLVAPVETVCMTPAEYHGLITAIILLMILLFSITLVAGLGYRRYWKSISKNRLVDRHSPIHSLGHSHSSIRTHERFTEIGHMPNLNGGGGGAAAGTGGGANQSASNRASNAFRTNMSMFGGSLHKTFATGNLARMCQLPVINPMRSTNQSSHQFEDPSEPIYTDPSLFERSRQVADHSVTHPQNEFPTTVRNYRCEV
Protein: Tat-binding protein-1 (Q9XZC3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVLDMAQTLEDKSIWEDGEESLGEKVMRMSTDEIVSRTRLMDNEIKIMKSEVIRITHEIQAQNEKIKDNTEKIKVNKTLPYLVSNVIELLDVDPQEEEDDGSVTVLDNQRKGKCAVIKTSTRQAYFLPVIGLVDAEKLKPGDLAGVNKDFYLILETLPAEYDARVKAMEVDERPTEQFSDIGGLDKQIQELIEAVVLPMTHKEKFKNLGIHPPKGVILYGPPGTGKTLLARACAAQTKSTFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPAIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLNGFSSTADIKVIAATNRVDILPALLRSGRLDRKIEFPHPNEEARARIMQIHSRKMNVSNDVNFEELSRSTDDFNGAQCKAVCVEAGMIALRRSANSVTHEDFMDAIMEVQAKKKANLNYYA
Protein: Protein Wnt-1 (Q91029)
Organism: Gallus gallus (Chicken)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. Developmental protein that promotes cell proliferation in the developing spinal cord. Has a role in osteoblast function, bone development and bone homeostasis (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P04628}. Secreted {ECO:0000250|UniProtKB:P04628}.
Interaction partners:
- Low-density lipoprotein receptor-related protein
- Porcupine O-acyltransferase.
- Wnt inhibitory factor 1
- Frizzled-1
- Notum, palmitoleoyl-protein carboxylesterase.
- Frizzled-4
- Frizzled-2
- Secreted frizzled-related protein 1
- Cerberus
- Secreted frizzled-related protein 2
Sequence:
MRGPALLLALRALCALSALRGTARAVNNSGRWWGIINVASSTNLLTDSGSVQLVLEPGLQLLSRKQRRLIRQNPGILHSVSAGLQSAVRECQWQFRNRRWNCPTSQGPNIFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSSEKGRDLRFLMNLHNNEAGRMTVFSEMRQECKCHGMSGSCTVRTCWMRLPTFRAVGDVLKDRFDGASRVIYGNKGSNRASRVELHHLEPENPAHKPPSPHDLVYFEKSPNFCTYSGKMGTAGTAGRACNSSSPGLDGCELLCCGRGFRTRTQRVTERCNCTFHWCCHVSCLNCTNTQVLHECL
Protein: Alcohol acyltransferase 17 (AdAT17) (EC 2.3.1.-) (P0DO26)
Organism: Actinidia deliciosa (Kiwi)
Function: Involved in the biosynthesis of volatile esters which confer kiwifruit flavor (By similarity). Alcohol acyl transferase that can use a wide range of alcohols as substrate to produce esters (By similarity).
Interaction partners:
Sequence:
MASFPPSLVFTVRRKEPTLVLPSKPTPRELKQLSDIDDQEGFRFQVPVIMFYKRKLYMEGEDPVKVIREALAEALVFYYPFAGRLIEGPNRKLVVDCTSEGVLFIEADADIELNQLIGDTIDPGTYLDELLHDVPGSEGIVGCPLLLIQVTRFRCGGWAFAIRLNHTMSDTLGLVQFLTTIAEFTRGAEDAPSVPPVWQREFLAARQPPFIPFQHHEYEQVIDTIPDDNKKSMTHKSFFFGPKEIRAIRSHLPHHHRSTSSTFDVLTACLWRCRTCALGLDPQMTVRISCAANGRGKHGLHVPRGYYGNVSAFPATVLRAGIISTSPLEYAMEGVKKAKAIMTGEYLRSVADLMVTKGRPRYTVAGNYIVSDMTRVGLDTIDFGWGKPVYGGPARAFPLISFYGRFKDNKGEDGTVVLICLPEAALERFQEELKKMTGEHVDGPFDYKPIKVVSKL
Protein: Holliday junction branch migration complex subunit RuvA (Q9A3G7)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Function: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00031}.
Interaction partners:
- Crossover junction endodeoxyribonuclease RuvC
- Holliday junction branch migration complex subunit RuvB
- Uncharacterized protein
- Peptide methionine sulfoxide reductase MsrB
- FtsW/RodA/SpoVE family cell cycle protein
- Large ribosomal subunit protein uL29
Sequence:
MIGRLRGAVAEVGEEEALIDVMGVGYLVRCGHRTLQRLPALGEETLLHIESQWSESAGLRLYGFLTREDRRAFVLLQAIQGVGPKAAMAVLDVLSPAELASAVAREDKAAVGRANGVGPKLALRIVTELKDKPITDGPVLMSAPTSSAPSAPAKPAPTGDAVAALMGLGVAEVNARRVVEAAAAELGEEATVQALIKAGLKELGR
Protein: Cytoskeletal protein syp1 (O43059)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Multi-functional protein that contributes to the endocytic process, but also to events that occur at the neck during cytokinesis. Plays a role as an endocytic adapters with membrane-tubulation activity that associates with transmembrane cargo proteins and initiates the formation of endocytic sites. Contributes to the stabilization of the nascent clathrin-coated pit. Also plays a role in late endocytosis by mediating vesiculation. Involved in the regulation of cell cycle-dependent dynamics of the septin cytoskeleton by promoting septin turnover in different cell cycle stages (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Uncharacterized calcium-binding protein C800.10c
- Probable clathrin heavy chain
- Clathrin light chain
- UBA domain-containing protein 8
- Actin cytoskeleton-regulatory complex protein pan1
- Actin cytoskeleton-regulatory complex protein end3
- AP-2 complex subunit mu
- Protein BZZ1
- AP-2 complex subunit alpha
Sequence:
MESLTKTEYVDAFLSNYSPNDSMSIFRQRLEQVRLDNDMLSQWIRERMDIERQYSDQLHKLAMNMQEKNNSSFAFNYAWKQLEGETLEISRYHSQIIGQIASQVYKPLIDYYTSSPQTATLRRLAERLSTVAEEMASSSVPGLKGLKKKGRDADTKSQNDLTASRATWDSDAPLAFEKLQIVDEERLLILKQVYLTIASLETDTALKQQEFFSKSMAVYSDLPIEGEIRQFMNSTSKVMSSASANKPSKSSGFHINNGKSKEEKSHGENESGGKLKNKMSTLFRRKTIMPKKDKKPSHKSNGRPNKLTAFFNKNSKASSISSAEEHPSNIDDSSIERRHYDSNHSSQIRDHPSTNNNASSYQNFNETSDEGEDNDATIRANNVRSSFLEAPLPVQPNVQAETVTPKISSKASPFNKPNSVHSEASRNTPSSIDRENASHSNPIMMHGNDFGGNFNNMQSRSTTTSPTSAVASPAPTENEDSNAAIERVANTLRKNPTISRRTRRAGTMDRYATASSDYMESNLGSLPNLSTLSLQSGPDSTATWHPEFPNSSGLSASIVEKYSGELSEDGLLHPSCSGHIFMKYTSDFNTPPPEMGVRVASEFPMSFTHLNDHAVKYGPSENTLSLIPELLLSPIKVTDFNLHLDSINGASCIPLTVVQKWKHDESSSSMIAFVKPNPVWRNLGSSLHIEKLVIIVYLGENVLVKSCQSSPAGEFSRKTSKLKLHLSNINISSSGFKILAKFAISPSAAIRKPVIEFRIRMVDSSNNPGLTKLFLKPDMFDTTSSSGGSQLESAYEETKVPTSYGIHVRECSVFADMS
Protein: Serpin family B member 13 (A0A0A0MQW3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDSLGAVSTRLGFDLFKELKKTNDGNIFFSPVGILTAIGMVLLGTRGATASQLEEVFHSEKETKSSRIKAEEKEVVRIKAEGKEIENTEAVHQQFQKFLTEISKLTNDYELNITNRLFGEKTYLFLQKYLDYVEKYYHASLEPVDFVNAADESRKKINSWVESKTNEKIKDLFPDGSISSSTKLVLVNMVYFKGQWDREFKKENTKEEKFWMNKSTSKSVQMMTQSHSFSFTFLEDLQAKILGIPYKNNDLSMFVLLPNDIDGLEKIIDKISPEKLVEWTSPGHMEERKVNLHLPRFEVEDGYDLEAVLAAMGMGDAFSEHKADYSGMSSGSGLYAQKFLHSSFVAVTEEGTEAAAATGIGFTVTSAPGHENVHCNHPFLFFIRHNESNSILFFGRFSSP
Protein: Dynein, cytoplasmic 1, intermediate chain 2a (E7F6H7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Plays a role in the development of anterior brain and cartilaginous structures.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O88487}. Cytoplasm {ECO:0000250|UniProtKB:O88487}.
Interaction partners:
- Dynein, cytoplasmic 1, heavy chain 1.
- Dynein light intermediate chain
- Dynein light intermediate chain
- Dynactin subunit 2
- Dynein cytoplasmic 2 heavy chain 1.
- Dynein light chain
- Dynein light chain roadblock-type 2.
- Dynactin 1a.
- Dynein light chain roadblock
- Dynein light chain Tctex-type 1
Sequence:
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKEAELKKDAVPLQDDSDLEKKRREADALLQSMGITSDVSAAPAPMSPTAKSVGSPSEAGSQDSGDGTTGPRTLHWDCDPSTVLLHSELGRGPLKLAMTKMTHVDFPPKEVVSYTKETQTPTMTEQKDEEDEEEETPAAQPEAETEKEKPEEKQVEEALPHELTEEEKLQILHSEEFMDFFDHSTRIVERALSEHVDVFFDYSGRDMEEKEGEMQAGTKLSLNRKFVDDRWSKQRVVTCLDWSPQYPELLVASYNNNEEAPHEPDGVALVWNMKYKKATPEYVFHCQSAVMSAAFAKFHPNLVVGGTYSGQIVLWDNRSNRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKMCSWSLDMLSQPQDSMELVFKQSKSVAVTSMSFPLGDVNNFVVGSEDGSVYTASRHGSRAGISEMFEGHHGPITGIHCHTAAGPVDFSHLFLTASFDWTVKLWSNKNNKPLYSFEDNSDYVYDVMWSPVHPALFACVDGLGRVDLWNLNNDTEVPTASVAVDGSPALNRLRWSQSGREIAVGDSEGQIHIYDVGEQIAVPRNDEWTRFVRTLVEINENRDDAEELAAQRLAA
Protein: RASGRF2 (A0A2X0SFL3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSCRPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQDGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKSEIIALNKTKERMRPYQSNQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDSKGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTTTTQSPAASPPPHTGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSPAADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNNTERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPRLPA
Protein: Zeaxanthin glucosyltransferase (EC 2.4.1.276) (Q01330)
Organism: Pseudescherichia vulneris (Escherichia vulneris)
Function: Catalyzes the glycosylation reaction which converts zeaxanthin to zeaxanthin bis(beta-D-glucoside). The reaction proceeds in two steps with the monoglucoside as an intermediate.
Interaction partners:
Sequence:
MSHFAIVAPPLYSHAVALHALALEMAQRGHRVTFLTGNVASLAEQETERVAFYPLPASVQQAQRNVQQQSNGNLLRLIAAMSSLTDVLCQQLPAILQRLAVDALIVDEMEPAGSLVAEALGLPFISIACALPVNREPGLPLPVMPFHYAEDKRALRRFQVSERIYDALMYPHGQTILRHAQRFGLPERRRLDECLSPLAQISQSVPALDFPRRALPNCFHYVGALRYQPPPQVERSPRSTPRIFASLGTLQGHRLRLFQKIARACASVGAEVTIAHCDGLTPAQADSLYACGATEVVSFVDQPRYVAEANLVITHGGLNTVLDALAAATPVLAVPLSFDQPAVAARLVYNGLGRRVSRFARQQTLADEIAQLLGDETLHQRLATARQQLNDAGGTPRAATLIEQAIAGSESVS
Protein: D(2) dopamine receptor (Dopamine D2 receptor) (P61168)
Organism: Mus musculus (Mouse)
Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P14416}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P14416}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Beta-arrestin-2
- Sodium-dependent dopamine transporter
- Guanine nucleotide-binding protein G
- Adenosine receptor A2a
- Cannabinoid receptor 1
- Guanine nucleotide-binding protein G
- Beta-arrestin-1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Neuronal calcium sensor 1
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
Protein: Ubiquitin-conjugating enzyme E2 13 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 13) (Ubiquitin carrier protein 13) (Ubiquitin-protein ligase 13) (O13685)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in the DNA error-free postreplication repair (PRR) pathway. The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.
Interaction partners:
- Ubiquitin-conjugating enzyme spm2
- Polyubiquitin
- Ubiquitin-activating enzyme E1 1
- DNA repair protein rad8
- DNA polymerase zeta catalytic subunit
- Protein sip5
- Postreplication repair E3 ubiquitin-protein ligase rad18
- ATP-dependent DNA helicase srs2
- General transcription and DNA repair factor IIH helicase subunit XPD
- Ubiquitin-ribosomal protein eS31B fusion protein
Sequence:
MALPKRIIKEIETLTRDPPPGIVAAPTEDNLRYFKITMEGPQQSAYEGGKFHLELFLPDEYPMMPPNVRFLTKIYHPNVDKLGRICLSTLKKDWSPALQIRTVLLSIQALMGAPNPDDPLDNDVAKIWKENEPQAIANAREWTKKYAV
Protein: Proline-rich protein 7 (Synaptic proline-rich membrane protein) (Q8TB68)
Organism: Homo sapiens (Human)
Function: Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN. Might play a redundant role in the regulation of T cell receptor signaling. Might promote apoptosis in T cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21460222}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P0C6T3}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P0C6T3}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21460222}. Synapse {ECO:0000269|PubMed:27458189}. Cell projection, dendrite {ECO:0000269|PubMed:27458189}. Nucleus {ECO:0000269|PubMed:27458189}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity). {ECO:0000250|UniProtKB:P0C6T3}.
Interaction partners:
- Proline-rich protein 9
Sequence:
MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPQPPPHRSRLEAPAHAHSHPHVHVHPLLHHGPAQPHAHAHPHPHHHALPHPPPTHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAPPCPALCLQADRGRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV
Protein: T. brucei spp.-specific protein (Q583V8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHRVITILSGYTRFFFLEKDVKIPSCIHPFRVRLEVFLHVPVFPSSLFIRFFLPFILRLALLSSVRRGLASKTSMGSHESTTLFFFSSCRLSFPPLLNSLSFSYLTFYFSFYGVAACSFICFVLGKRRVEGRISHENFFEYLLLTFFFKSFPHLVDPLVVNNYQPAFVCVWRCCDELESRTRERWKVGQLQLHPSAASFSCCLFVAVVVLVVVVVLCFPVPFPTCFPFAVFVVSHHRNYRRCFYLLYTSIGRGPMHPLEFWLMSE
Protein: TPA-induced transmembrane protein (Q5BVD1)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:32336749}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDLAQPSQPVDELELSVLERQPEENTPLNGADKVFPSLDEEVPPAEANKESPWSSCNKNVVGRCKLWMIITSIFLGVITVIIIGLCLAAVTYVDEDENEILELSSNKTFFIMLKIPEECVAEEELPHLLTERLTDVYSTSPSLGRYFTSVEIVDFSGENATVTYDLQFGVPSDDENFMKYMMSEELVLGILLQDFRDQNIPGCESLGLDPTSLLLYE
Protein: Myocardin related transcription factor A (A0A8I5Y983)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLTASELCTKADARLVLYTVHLLDMGLGADSPSCPPSCVLAAGVLHWLCISVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLESRASDLLPSATSISPTQVLSQLPMAPDPGETLFLAEQPPLPPPPLLPPSLTSGSIVPTAKPAPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDKGAPAMDSSYAKILQQQQLFLQLQILNQQQQQQQQQHYNYQAILPAPPKPSGETPGSSAPTPSRSLSTSSSSSSGTPGPGGLARQNSTALAGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQVSPAPGAPKAPATTSVLSKAGEVVVAFPAALLSTGSALVTAGLAPAEMVVATVTSNGMVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDAFGEMVTSPLTQLTLQASPLQIVKEEGARAASCCLSPGARAELEGLDKDQMLQEKDKQIEELTRMLQQKQQLVELLRLQLEQQKRAQQPAPASSPVKRESSFSSCQLSCQPQGAARAFGPGLVVPTTNHGDAQAPAPESPPVVVKQEAGPPEPDLAPASQLLLGSQGTSFLKKVSPPTLVTDSTGTHLILTVTNKSADGPGLPTGSPQQPLSQPGSPAPGPPAQMDLEHPPQPSFATPTSLLKKEPPGYEETVTQQPKQQENGSSSQHMDDLFDILIQSGEISADFKEPPSLPGKEKSPPAEAYGPPLTPQPSPLSELPQAAPPPGSPTLPGRLEDFLESSTGLPLLTSGHEGPEPLSLIDDLHSQMLSSSAILDHPPSPMDTSELHFAPEPSSGMGLDLAVGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSMDFLDGHDLQLHWDSCL