wanglab/gogpt-training-data huggingface dataset:
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (C8VHB6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM2
- G1/S regulator
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM7
- non-specific serine/threonine protein kinase
- DNA replication licensing factor MCM3
- DNA replication protein, putative
- Hypothetical nuclear condensin complex subunit 3
Sequence:
MSMLDAPSTSMPDLQRTQTVSQLSKYDRKSRTAANYGQLLEKPDQEHDHEEDDQEEEVDEVVLEDMKKLEDNFPGISDRFRLVNRIGEGTFSTVYKAEDLLYDHYRNDWDVFQDTPRDESTNSPSKGRRVEDENGNTIPIRRTKPRYVALKKIYVTSSPLRIQNELELLHDLRGCRSVCPLITAFRHHDQVVAVLPFFPHTDFRLQYRTFMVADMRHYFRSLFTALHSVHKHNILHRDIKPTNFLYNPDLREGVLVDFGLAEREGSEYTGTCLCTSTSHIRRARYTQSYHYTHCASSGLAIGYPKSDSRPSRRANRAGTRGFRAPEVLFKCTSQTTKIDMWSAGVILLTLLGRRFPFFNSADDVDALIEMASIFGTRRMKNAAAMHGQIFETNIPTIGEKGYSWEKLVKWSSCVEELTESEKQATRLLAGLMELDPSKRLNAKEAMQHEFFTNPIDHDVEWGGPEDSADSGREDEGDKGGDDDGDDDEVDMV
Protein: Suppressor of cytokine signaling SOCS36E-II (Q8WTC2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGHHLSKFSARANSQEKRNPTASSSPREAAALVETISLDEEELQVEEILTEATVSAATSPAEVRQIIIKIQLAKMENGNPVAAGQVESFAEVVEQEEEQQRQCADGATDDDAAALSADSLNANGQIVNVTLEGGYGEVGVVTNRTAGSSPEAAKTERQPVNNNGLAGSVGAAISTLQLHDNHGGNANCPLEADDDDDLDESLLRRRRSNSNSRSNIHHHHHHHQQQQQQQHEAEVVEYCEVLESLPVSNMLSAGTQHSSKPVSRSNNSNSCCRSRSSKALSMGAATSSASGSASTSVSTSTSSKRRCCKCKCRDAIRGLRDMLPSSSSSVSNKKDAAAVVAMVPRKSRTADRRSTPPTLGTSSGGSQRRMQSQRIRNSVAVPDASHHHHQLIIRITSPGFVVESPNGGRVTVVTEPAPQSPQTPPRPRPLATVAPAGGAGHAGIGAARNMTVHSQIDFMHCLVPDLEKITNSSFYWGKIRWTATRRSTCSRGKQNPETKTQTETIPVQRCRHHKLKDQTRSHITKSLAPTTRLSWIKNQMFTIYISPIECSSDGFLSCGTLESELVE
Protein: Jacalin-related lectin 20 (Myrosinase-binding protein-like At2g25980) (O80998)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Beta-glucosidase 21
- Protein TEEBE
- Beta-glucosidase 22
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- chitinase
- GDP-mannose 4,6 dehydratase 1
- Transmembrane protein
- Putative F-box/FBD/LRR-repeat protein At1g66300
Sequence:
MAQRLEAKGGKGGNQWDDGADHENVTKIHVRGGLEGIQFIKFEYVKAGQTVVGPIHGVSGKGFTQTFEINHLNGEHVVSVKGCYDNISGVIQALQFETNQRSSEVMGYDDTGTKFTLEISGNKITGFHGSADANLKSLGAYFTPPPPIKQEYQGGTGGSPWDHGIYTGIRKVYVTFSPVSISHIKVDYDKDGKVETRQDGDMLGENRVQGQPNEFVVDYPYEYITSIEVTCDKVSGNTNRVRSLSFKTSKDRTSPTYGRKSERTFVFESKGRALVGLHGRCCWAIDALGAHFGAPPIPPPPPTEKLQGSGGDGGESWDDGAFDGVRKIYVGQGENGIASVKFVYDKNNQLVLGEEHGKHTLLGYEEFELDYPSEYITAVEGYYDKVFGSESSVIVMLKFKTNKRTSPPYGMDAGVSFILGKEGHKVVGFHGKASPELYQIGVTVAPITK
Protein: Phosphoserine phosphatase, chloroplastic (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase) (O82796)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the last step in the plastidial phosphorylated pathway of serine biosynthesis (PPSB). The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Required for embryo, pollen and root development. May be required preferentially for serine biosynthesis in non-photosynthetic tissues.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:10196182, ECO:0000269|PubMed:23771893}.
Interaction partners:
- Phosphoserine aminotransferase 1, chloroplastic
- Phosphoserine aminotransferase 2, chloroplastic
- Serine--glyoxylate aminotransferase
- Serine hydroxymethyltransferase 2, mitochondrial
- Serine hydroxymethyltransferase 1, mitochondrial
- Serine hydroxymethyltransferase 3, chloroplastic
- Serine hydroxymethyltransferase 5
- Serine hydroxymethyltransferase 7
- Serine hydroxymethyltransferase 6
- Serine hydroxymethyltransferase 4
Sequence:
MEALTTSRVVPVQVPCRKLSSLFANFSCLELRRYPCRGLVSIMNHPKLLRPVTASVQPHELSTLGHEGNIVPSKEILDLWRSVEAVCFDVDSTVCVDEGIDELAEFCGAGKAVAEWTARAMGGSVPFEEALAARLSLFKPSLSKVEEYLDKRPPRLSPGIEELVKKLRANNIDVYLISGGFRQMINPVASILGIPRENIFANNLLFGNSGEFLGFDENEPTSRSGGKAKAVQQIRKGRLYKTMAMIGDGATDLEARKPGGADLFICYAGVQLREAVAANADWLIFKFESLINSLD
Protein: Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613) (Q9UN36)
Organism: Homo sapiens (Human)
Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase 38-like
- N-myc proto-oncogene protein
- Protein NDRG1
Sequence:
MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC
Protein: rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (Histone-glutamine methyltransferase) (Nucleolar protein 1) (U6 snRNA 2'-O-methyltransferase fibrillarin) (P35550)
Organism: Mus musculus (Mouse)
Function: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:30283081}. Nucleus, nucleoplasm {ECO:0000305|PubMed:32017896}. Note=Fibrillar region of the nucleolus. {ECO:0000250|UniProtKB:P22087}.
Interaction partners:
- NHP2-like protein 1
- Nucleolar protein 56
- Nucleolar protein 58
- H/ACA ribonucleoprotein complex subunit DKC1
- U3 small nucleolar RNA-interacting protein 2
- Nucleolar and coiled-body phosphoprotein 1
- H/ACA ribonucleoprotein complex subunit 1
- Small ribosomal subunit protein uS9
- H/ACA ribonucleoprotein complex subunit 2
- Periodic tryptophan protein 2 homolog
Sequence:
MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGRGGFGGGRGGFGGGGRGRGGGGGGFRGRGGGGGRGGGFQSGGNRGRGGGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN
Protein: Transforming growth factor beta (Q6T7C3)
Organism: Oryctolagus cuniculus (Rabbit)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSYFPSETVCPVVTTPSGSVGSLCARQSQVLCGYLDAIPPTFYRPYFRIVRFDVSTMEKNASNLVKAEFRVFRLQNPKARVAEQHIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
Protein: Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Q9JIS1)
Organism: Rattus norvegicus (Rat)
Function: Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Protein unc-13 homolog A
- Ras-related protein Rab-3A
- Rap guanine nucleotide exchange factor 4
- Protein unc-13 homolog C
- Protein unc-13 homolog B
- Peripheral-type benzodiazepine receptor-associated protein 1
- RIMS-binding protein 2
- ELKS/Rab6-interacting/CAST family member 1
- Protein piccolo
- Ras-related protein Rab-3C
Sequence:
MSAPLGPRGRPAPTPAASQPPPQPEMPDLSHLTEEERKIIQAVMDRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSNTPQQPDQKALRGLRSEEAPQEKKAKLHEQTQFQGPPGDSSVPAVERGRAHGLTRQDSIKNGSGMKHQIASDMPSDRKRSPSVSRDQNRRYDQSEEREEYSQYVPSDSTMPRSPSDYADRRSQREPQFYEEPDHLNYRDSNRRGHRHSKEYIVDDEDVESRDEYERQRREEEYQARYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANAELEDSRISLLRMDRPSRQRSVSERRAAMENQRSYSMERTREAQGQSSYPQRTTNHSPPTPRRSPIPLDRPELRRADSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPRPHKSKKGGKMRQVSLSSSEEELASTPEYTSCDDVEIESESVGEKGDMEYSWLEHASWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDMPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCEDGVGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSWSPSVPPPQRNVEQGLRGTRATGHYNTISRMDRHRVMDDHYSSERDSHFLTLPRSRHRQTSEHHHRDGRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSSERADTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVTGRRGRQLPQLPPKGTLERMITEDMDSTRKRNSGAMDIEERNRQMKLNKYKQVAGSDPRLEQDYHSKYRSGWDPHRGADTVSTKSSDSDVSDVSAVSRTSSASRFSSTSYMSVQSERPRGNRKISVFTSKMQSRQMGVSGKSMAKSTSISGDMCSLEKNDGSQSDTAVGALGTSGKKRRSSIGAKMVAIVGLSRKSRSASQLSQTEGGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS
Protein: Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) (Q61006)
Organism: Mus musculus (Mouse)
Function: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:19038220}; Single-pass type I membrane protein {ECO:0000269|PubMed:19038220}. Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction.
Interaction partners:
- Protein Dok-7
- Agrin
- Acetylcholinesterase collagenic tail peptide
- 43 kDa receptor-associated protein of the synapse
- Segment polarity protein dishevelled homolog DVL-1
- Acetylcholinesterase
- Acetylcholine receptor subunit delta
- Nesprin-1
- Dystroglycan 1
- Acetylcholine receptor subunit epsilon
Sequence:
MRELVNIPLLQMLTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCIANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDNALRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEVEVFARILRAPESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKDSQGYCAQYRGEVCDAVLAKDALVFFNTSYRDPEDAQELLIHTAWNELKAVSPLCRPAAEALLCNHLFQECSPGVVPTPMPICREYCLAVKELFCAKEWQAMEGKAHRGLYRSGMHLLPVPECSKLPSMHRDPTACTRLPYLDYKKENITTFPSITSSRPSADIPNLPASTSSFAVSPAYSMTVIISIVSSFALFALLTIATLYCCRRRKEWKNKKRESTAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCERAEGTVGV
Protein: Arginase 2, chloroplastic/mitochondrial (EC 3.5.3.1) (Agmatinase ARGAH2) (EC 3.5.3.11) (Arginine amidohydrolase 2) (Q9ZPF5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the hydrolysis of L-arginine to urea and L-ornithine. The latter can be utilized in the urea cycle or as a precursor for the synthesis of both polyamines and proline (By similarity). Possesses agmatinase activity. Catalyzes the formation of putrescine from agmatine.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:18567826}. Plastid, chloroplast {ECO:0000269|PubMed:28716421}.
Interaction partners:
- Arginine decarboxylase 2
- Ornithine aminotransferase, mitochondrial
- Arginine decarboxylase 1, chloroplastic
- Ornithine transcarbamylase, chloroplastic
- Argininosuccinate lyase, chloroplastic
- Arginine biosynthesis bifunctional protein ArgJ
- Acetylornithine deacetylase
- Urease
- At1g44820
- NO-associated protein 1, chloroplastic/mitochondrial
Sequence:
MWKIGQRGVPYFQRLIAAPFTTLRSLPTSLVETGQNRVIDASLTLIRERAKLKGELVRLIGGAKATTALLGVPLGHNSSFLEGPALAPPHVREAIWCGSTNSTTEEGKELKDPRVLSDVGDIPVQEIREMGVDDDRLMKVVSESVKLVMEEEPLRPLVIGGDHSISYPVVRAVSEKLGGPVDILHLDAHPDIYDRFEGNYYSHASSFARIMEGGYARRLLQVGIRSINKEGREQGKRFGVEQYEMRTFSKDRQMLENLKLGEGVKGVYISIDVDCLDPGFAHGVSHFEPGGLSFRDVLNILHNLQGDLVGADVVEYNPQRDTADDMTAMVAAKFVRELAAKMSK
Protein: Regulator of nonsense transcripts UPF3 (Nonsense mRNA reducing factor UPF3) (Up-frameshift suppressor 3 homolog) (AtUpf3) (Q9FVW4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (premature termination codon PTC) by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Eliminates the production of nonsense-containing RNAs (ncRNAs). Required for plant development and adaptation to environmental stresses, including plant defense and response to wounding.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:19602621}. Nucleus {ECO:0000269|PubMed:26887918}. Cytoplasm {ECO:0000250}. Note=Shuttling between the nucleus and the cytoplasm. {ECO:0000250}.
Interaction partners:
- Regulator of nonsense transcripts UPF2
- Regulator of nonsense transcripts 1 homolog
- Protein mago nashi homolog
- Eukaryotic initiation factor 4A-III homolog
- RNA-binding protein Y14
- Nonsense-mediated mRNA decay factor SMG7
- At2g29210/F16P2.41
- Nuclear cap-binding protein subunit 1
- Nuclear cap-binding protein subunit 2
- Initiation factor 4A-like protein
Sequence:
MKEPLQKKKVVVRHLPPSLSQSDLLSQIDPRFADRYNWVSFRPGKSSYKNQKYSRAYVSFKAPEDVYEFAAFFNGHVFVNEKGAQFKAIVEYAPSQRVPKPSDKKDPREGSISKDPDYLEFLKVIAQPVENLPSAEIQLERREAEQSGASKAAPIVTPLMEFIRQKRATVMGPQGLSDIRRGGRRTRVVSANKPSPRPSKRNSEKKKYVEKESSKNVPRKTTADVSSSKPDYRQSNSSGKELPGNETAAIIDSSPPGIALTMDSGKKKILLLRSKDRDNPDNPPPQPEQHIDTNLSRNSTDSRQNQKSDVGGRLIKGILLRNDSRPSQSSTFVQSEQRVEPSEAENYKRPSRPANTRAGKDYHTSGTISEKQERRTRNKDRPDRVMWAPRRDGSEDQPLSSAGNNGEVKDRMFSQRSGEVVNSSGGHTLENGSARHSSRRVGGRNRKEEVVIGEGKTSRRGSGGGPSSHEKQMWIQKPSSGT
Protein: Isochorismatase family protein YecD (EC 3.-.-.-) (P0ADI7)
Organism: Escherichia coli (strain K12)
Interaction partners:
- UPF0759 protein YecE
- Inner membrane protein YecN
- Probable hydrolase YcaC
- ATP-dependent lipid A-core flippase
Sequence:
MLELNAKTTALVVIDLQEGILPFAGGPHTADEVVNRAGKLAAKFRASGQPVFLVRVGWSADYAEALKQPVDAPSPAKVLPENWWQHPAALGATDSDIEIIKRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDACSAASAEQHNNSINHIYPRIARVRSVEEILNAL
Protein: ExbD/tolR family transport protein (Q0PC27)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004249}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004249}. Cell membrane {ECO:0000256|RuleBase:RU003879}; Single-pass type II membrane protein {ECO:0000256|RuleBase:RU003879}.
Interaction partners:
- MotA/TolQ/ExbB proton channel family protein
- Periplasmic protein
- Biopolymer transport protein
- ExbB/tolQ family transport protein
- Tol-Pal system protein TolB
- Peptidoglycan-associated lipoprotein
- TonB transport protein
- TonB transport protein
- TonB transport protein
- ATP synthase epsilon chain
Sequence:
MPFDDEKPELNITPLVDIMLVLLAILMVTAPSITYEEKINLPQGSQKNTSTPTVKSLIISINAKKEIFLNQEKYDFISFADNLAQRKAQFNTEDPVFIRADKSLKYDDVISVLRSVKNLGFNKVALQTE
Protein: Photosystem II CP43 reaction center protein (Q8HT11)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Plastid, chloroplast thylakoid membrane {ECO:0000256|RuleBase:RU004533}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU004533}.
Interaction partners:
Sequence:
MKTLYSLRRFYHVETLFNGTLALAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVIDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGVGAFLLVFKALYFGGVYDTWAPGGGDVRKITNLTLSPSVIFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICIFGGIWHILTKPFAWARRALVWSGEAYLSYSLAALSVCGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRXQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLXPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAP
Protein: GTPase Era, mitochondrial (H-ERA) (hERA) (Conserved ERA-like GTPase) (CEGA) (ERA-W) (ERA-like protein 1) (O75616)
Organism: Homo sapiens (Human)
Function: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.
Subcellular location: Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane.
Interaction partners:
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein mS39
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein mS27
Sequence:
MAAPSWRGARLVQSVLRVWQVGPHVARERVIPFSSLLGFQRRCVSCVAGSAFSGPRLASASRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLGAPNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQVILLDTPGIISPGKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDCLKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWPHFKEIFMLSALSQEDVKTLKQYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHLPQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLMDIFLCDVDIRLSVKLLK
Protein: ER lumen protein-retaining receptor 2 (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2) (Q5U305)
Organism: Rattus norvegicus (Rat)
Function: Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P33947}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P33947}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250|UniProtKB:P33947}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. {ECO:0000250|UniProtKB:P33947}.
Interaction partners:
- Leucine-rich repeats and immunoglobulin-like domains 3
- Transmembrane emp24 domain-containing protein 7
- Coatomer subunit delta
Sequence:
MNIFRLTGDLSHLAAIVILLLKIWKTRSCAGISGKSQLLFALVFTTRYLDLFTSFISLYNTSMKLIYIACSYATVYLIYMKFKATYDGNHDTFRVEFLVVPVGGLSFLVNHDFSPLEILWTFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLVNWIWRFYFEGFFDLIAVVAGVVQTILYCDFFYLYITKVLKGKKLSLPA
Protein: Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (GCS) (Gamma-glutamylcysteine synthetase) (Q09768)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.
Interaction partners:
- Putative glutamate--cysteine ligase regulatory subunit
- Glutathione synthetase large chain
- Uncharacterized protein C11D3.15
- Uncharacterized protein C11D3.14c
- Glutathione hydrolase proenzyme 1
- Cysteine synthase 1
- Cysteine synthase 2
- Cys-Gly metallodipeptidase dug1
- Glutathione hydrolase proenzyme 2
- Putative aminopeptidase C13A11.05
Sequence:
MGLLVLGTPLDWPESKKYCDYVRENGIMQFLHMYDTYISKKQDVLLWGDEIECIVVSMDDKSKKARVSLRQEDILNALGKYEETFRHVDFGPVYAALRNETCPKKIDAILSEVAKNPADYVERIGGNSNKDTIEITSSTKPHAQNAVPTFHPEYGRYMLESTPGAPYGSTLKDFTFVEYNMRLRRKIIENHLLPNELPLTITNFFRLGTPGFTDPEVEANGAISRSFFLPDDVINTHVRFPTLTANIRQRRGRKVAMNVPIFFDKNTIKPFHDPTVPWDRNLFPEDANARDGAALDNHIYMDSMGFGMGCCCLQITFQAKSCDEARLLYDQLTPITPLMLALSAGTPAFRGYLADQDCRWNVIAGAVDDRTEEEMKTVPKSRYDSVDLYISNDKRNLPEYNDVPVVINQDCYDKLIKDCIDERLAKHMAHIFSRDPLVIFSDSILQDNSVSNAHFENLNSTNWQSMRFKPPPPGSDIGWRVEFRSMEIQITDFENAAYSIFVVMLSRAILSFNLNLYMPISLVDENMKAAHARDAIHRKKFWFRCNPFPDASTDDESGQFRQLTIDELFNGEHRENGFPGLITIVRSYLYSCNPDAKTICLIERYIRLISQRANGQCLTAASWIRNFITTHPSYKQDSVVNDEINYDLIRRIAKIVDGDYDDTLLGKCS