wanglab/gogpt-training-data huggingface dataset:
Protein: Protein N-terminal glutamine amidohydrolase (EC 3.5.1.122) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) (O22944)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Involved in immune response. Controls the expression of specific defense-response genes, activates the synthesis pathway for the phytoalexin camalexin, and influences basal resistance to the hemibiotroph pathogen Pseudomonas syringae pv tomato (Pst).
Interaction partners:
- Protein N-terminal asparagine amidohydrolase
- Arginyl-tRNA--protein transferase 1
- E3 ubiquitin-protein ligase PRT1
- Arginyl-tRNA--protein transferase 2
- E3 ubiquitin-protein ligase PRT6
Sequence:
MSGVTSEPIAMDATRFQHTPYYCEENVYLLCKTLCENGVAEATCSDLFVVFISNEKKQVPLWHQKASTRADGVVLWDYHVICVQRKKESDSEPLVWDLDSTLPFPSPLASYVTETIQPSFQLFAEYQRFFRIVHAPLFFKHFASDRRHMKEPDGSWTAQPPPYEPIVAQDGILHNLSEYIAMSGADTLSSLDPETVTAAISQKLGVVVSHTQLQDLFTKLP
Protein: Uncharacterized protein (Q382Z3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGTVSPARRVASPGKGKRSPSRGETPSEGRTRRAGSSPSSRPGMQTASQRAARKKEVRRLRDAELLLDEAPLSMVGERAQDALEAMLRALDIRRNASATPKKMQPVWHHVKALVVTANREGLRRAYAAFPAEEGHYFFGKALSTLEYSASTVNTAADGGEFAECPLLLSHLMEATLNNIAFQQYIAHEPPEAILKTLQRALKVQHHQAFRTLTLYNMAVAFLAARRYEDATEFVARCSQVAEVCLELEVSLTREISSLYKEYHTMVATHAIMCHHLLAGLAAWSGESDMEVYHAQLALCCATKFLAEGSALVSRCQQRLTAAKSGNSAAVIAQSDEPPRMQMMTDDLEILASPLFLQFLLETQRMQRIVFPPLKGLQRRKTVVKRGQRLGSGKSSPEVEAEDTGLTGSAPHQPAVDGNGEEEKAGTHASISYSRSPSQGVGATTDVRIVCSPVACIATGCDMRTGDGVRVLQRSSQGRKGADVLFGSTA
Protein: Stretchin-MLCK (Q9GTV0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHNIFFSIDILNKSRMDKVHTRHGNIETLPRFVRNLRNLRCCDGDAISLECHVEADPEPFIIWEKDGHVMPSDRDYVMSFDGTKATLSIPRVYPEDEGEYTCVAKNSVGRSLSSACIIVDVPEEKENMLSRQLARPSGLLSAHSTPRSTPRSTPARSFSPLRLSYRTSSIDLSGVAERRRSDARNAITAPKFLAIPYNRVVEEGDSVRF
Protein: Heme uptake protein MmpL11 (P9WJT9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of a heme-iron acquisition system. Receives heme from the heme-binding protein Rv0203 and transports it into the mycobacterial cell. Contributes to virulence.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:23760277}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Conserved protein
- Heme-binding protein Rv0203
- Conserved protein
- Serine/threonine-protein kinase PknG
Sequence:
MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSADVRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKALDQVQLAYRNGIARAISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPVETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPGRQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR
Protein: H-N-H endonuclease F-TflII (EC 3.1.21.-) (HNH endodeoxyribonuclease F-TflII) (HNH endonuclease F-TflII) (Q6QGM6)
Organism: Escherichia phage T5 (Enterobacteria phage T5)
Function: Endonuclease that cleaves only one strand of asymmetric DNA substrates threrby introducing interruptions into the template or coding strand.
Interaction partners:
Sequence:
MKLENFKVIPEYPEYLISPYGEVYSTKSNKLLTHHLGSAGYPFVTFYEQGKNVSIVLHRLLARVFKDLPSLESELEVDHKDRNKLNFSLDNLVVMTKQDHRIKTTVERGHTIGGNKCPYCNKQINSSSKTCFDCKPKSSPDITAEQIEYWVINYSWVKASKELGLSDNGLRKRYKSLTGKDPKSIKKKVSQVG
Protein: Proline-rich receptor-like protein kinase PERK13 (EC 2.7.11.1) (Proline-rich extensin-like receptor kinase 13) (AtPERK13) (Protein ROOT HAIR SPECIFIC 10) (Q9CAL8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates negatively root hairs elongation.
Subcellular location: Cell membrane {ECO:0000269|Ref.7}; Single-pass membrane protein {ECO:0000269|Ref.7}.
Interaction partners:
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Expansin-A7
- Leucine-rich repeat extensin-like protein 1
- Proline-rich protein 3
- Putative methylesterase 15, chloroplastic
- Expansin-A18
- Serine/threonine-protein kinase KIPK2
- Probable pectate lyase 16
- Leucine-rich repeat extensin-like protein 2
- Protein DETOXIFICATION 31
Sequence:
MSDSPTSSPPAPSADSAPPPDTSSDGSAAPPPTDSAPPPSPPADSSPPPALPSLPPAVFSPPPTVSSPPPPPLDSSPPPPPDLTPPPSSPPPPDAPPPIPIVFPPPIDSPPPESTNSPPPPEVFEPPPPPADEDESPPAPPPPEQLPPPASSPQGGPKKPKKHHPGPATSPPAPSAPATSPPAPPNAPPRNSSHALPPKSTAAGGPLTSPSRGVPSSGNSVPPPANSGGGYQGKTMAGFAIAGFAVIALMAVVFLVRRKKKRNIDAYSDSQYLPPSNFSIKSDGFLYGQNPTKGYSGPGGYNSQQQSNSGNSFGSQRGGGGYTRSGSAPDSAVMGSGQTHFTYEELTDITEGFSKHNILGEGGFGCVYKGKLNDGKLVAVKQLKVGSGQGDREFKAEVEIISRVHHRHLVSLVGYCIADSERLLIYEYVPNQTLEHHLHGKGRPVLEWARRVRIAIGSAKGLAYLHEDCHPKIIHRDIKSANILLDDEFEAQVADFGLAKLNDSTQTHVSTRVMGTFGYLAPEYAQSGKLTDRSDVFSFGVVLLELITGRKPVDQYQPLGEESLVEWARPLLHKAIETGDFSELVDRRLEKHYVENEVFRMIETAAACVRHSGPKRPRMVQVVRALDSEGDMGDISNGNKVGQSSAYDSGQYNNDTMKFRKMAFGFDDSSDSGMYSGDYSVQDSRKGSNGASSEFTRNETENRNFNNRRY
Protein: Exocyst subunit Exo70 family protein (F4K8Y6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Exocyst complex component EXO84C
- Exocyst complex component SEC8
- Exocyst complex component SEC6
- Exocyst complex component SEC5A
- Exocyst complex component SEC5B
- Exocyst complex component SEC10a
- Exocyst complex component EXO84B
- Exocyst complex component SEC3A
- Exocyst complex component SEC3B
- Exocyst complex component EXO84A
Sequence:
MAATTTTAASINAEAGGGGGGAEDRVLATAQQIMKSLNTPKEVREDMLLIFSSFDNRLSNIKTAMTNQEENQNDALVARLEAAESVIHRWDGGNDSSRHSSSSSGNYRSSSFSLSFDESPEEATEFLSAVDEIISLLEDLSSENKPDMVDRADSALQMAMSQLEDEFRRILIRNTVPLDAERLYGSMRRVSLSFADGDVVEDFENFGLVADGDGSGSRRRLFHERGGSIGCDLWVDLINPTAVEDLKEIAERMIRAGYEKECVQVYSSVRRDALDDCLMILGVEKLSIEEVQKIDWKSMDEKMKKWIQAVKITVRVLLVGEKKICDEIFSSSESSKEVCFNETTKSCVMQLLNFGEAVAIGRRSSEKLFRILDMYDALANVLQTLEVMVTDCFVCNETKGVLEALGDAARGTFVEFENNVRNETSKRPTTNGEVHPMIRYVMNYMKLIVDYAVTLNSLLESNESSGVSGDDSTEEMSPLAKRILGLITSLESNLEDKSKLYEDGGLQHVFMMNNIYYIVQKVKDSELGKLLGDDWVRKRRGQIRQYATGYLRASWSRVLSALRDESMGGSSSGSPSYGQRSNNSSKMALKERFRGFNASFEELYRLQTAWKVPDPQLREELRISISEKVIPAYRAFFGRNRSQLEGGRHAGKYIKYTPDDLESYLPDLFEGNQLVIHHPRRKS
Protein: Cytochrome P450, family 706, subfamily A, polypeptide 3 (Flavonoid 3',5'-hydroxylase-like; cytochrome P450) (Q9LU04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- B3 domain-containing protein At3g06220
- At4g10262
- NAD
- UDP-glycosyltransferase 91B1
Sequence:
MTDISSLFRNRSRKDQLDYGLTVIVISTLCWCLWLYAKCKRRSPPLPPGPWGLPIIGNLPFLQPELHTYFQGLAKKHGPIFKLWLGAKLTIVVTSSEVAQEILKTNDIIFANHDVPAVGPVNTYGGTEIIWSPYGPKWRMLRKLCVNRILRNAMLDSSTDLRRRETRQTVRYLADQARVGSPVNLGEQIFLMMLNVVTQMLWGTTVKEEEREVVGAEFLEVIREMNDLLLVPNISDFFPVLSRFDLQGLAKRMRRPAQRMDQMFDRIINQRLGMDRDSSDGRAVDFLDVLLKVKDEEAEKTKLTMNDVKAVLMDMVLGGTDTSLHVIEFAMAELLHNPDIMKRAQQEVDKVVGKEKVVEESHISKLPYILAIMKETLRLHTVAPLLVPRRPSQTTVVGGFTIPKDSKIFINAWAIHRNPNVWENPLKFDPDRFLDMSYDFKGNDFNYLPFGSGRRICVGMAMGERVVLYNLATFLHSFDWKIPQGERVEVEEKFGIVLELKNPLVATPVLRLSDPNLYL
Protein: ZZ-type zinc finger-containing protein (Q55CE3)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasmic vesicle, autophagosome {ECO:0000256|ARBA:ARBA00004419}.
Interaction partners:
- Autophagy-related protein 8
- Autophagy-related protein 8-like protein DDB_G0290491
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin domain-containing protein
- Ubiquitin domain-containing protein
- PARP catalytic domain-containing protein
- PB1 domain-containing protein
- Ubiquilin
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-like domain-containing protein
Sequence:
MVNLILKIQHNDDTRRVSMERDPTFLELRKMTVTFFKINSFLIKYFDEDKDLITITSDNDLKEAFSIATTSPRTVRLFVSKTEEESSSETINNNNTTPSINNYQNPLSNSVNNNNNNNNNNDNNTMNLKPLIDSILANPNIAQLASASAVSCLTPKVHTSVYGIPTTGTDQTQIENLLSNLGSQNWINEIVQNSLSNIFKPNVNNNNQNQNQSTTTNNNNTTTTTTTSTTKNEEKQKTEKNENMVEHVGITCDGCDSKVFGNRYKCTVCHDYDLCSECESRGDQVHPTSHPLLKIAQPTPISCSWQHSNAGRSGIPHGFGGGRCTRKVYAARYLADISIKDGSVIPKGSSFTKTWRLRNDGKTSWPENTTLSFLSGDRFQYQTDIFVPVCQPGQDIDISVDLVAPTKTGRYTGYWRLSTPEGFGFGQSIWVDIYVIADEDDNKKQQPIIQEEKQQEEEQKDVVQRLPDSDSEDELLKQEQEKLEEEEEEEEEEKDEPKIEEEADSFCFLPFTPSPFSPFSIQNNVPASVQVPSEISNSFNIPPVAEQQQQEKINNNTSNNSNNYQLPPLPVVEQEQIIENVQPQVEELPKLEELSVNGEQEDIRRKCIGTLVSMGFSNTPNIIEIIKRYNFNINEIIDHLLSNQEQ
Protein: tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit (WD repeat-containing protein 4 homolog) (Q93WD7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|HAMAP-Rule:MF_03056}.
Interaction partners:
- tRNA
- tRNA
- tRNA
- tRNA
- Periodic tryptophan protein 2
- tRNA
- Putative tRNA
- At5g26910
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- tRNA-specific adenosine deaminase TAD3
Sequence:
MQEESHIEEVEIQNKLEVAPALISVHPSQKSVAVAVGSDLRIFDLIENCPVSLVDESDGPIRKESIRAIRYSTSGKLFVSAGDDKLVKIWSADSWRCLNTVCSEKRVSAVAISSDDSHVCYADKFGVVWVIELDGINDGKTLPSKKGALLLSHYCSIITSLEFSPDGRYILSADRDFKIRVTVFPKKPLEGAHEIQSFCLGHSEFITCTAFVSTPELTQGYLMSGSGDSTVRLWDITSGSLLDTCEVSTVAGHAESNENESPTQVTVTDICAIPNSSLAAVAIQSFQGIFLLSCDLTAHTLSITKVIKIPGESFIPTSIAVSASSRLLWMVSGASNLPGSNHPGFSRVRVISCLETESSSILEDEQIPGGTKLLEQLQGKVTIEESVMSAAAEAVRAAMSSLLMKKQYSEEKREFRKRTRNDKKTTR
Protein: Aquaporin-0a (Major intrinsic protein of lens fiber 1) (Major intrinsic protein of lens fiber a (EC 1.11.1.6)) (Q6DEI6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Aquaporin-10b
- Beaded filament structural protein 1.
- Aquaporin
- Beaded filament structural protein 2, phakinin
- Alpha-crystallin A chain
- Aquaporin 7
- Aquaporin
Sequence:
MWEFRSMSFWRAVFAEFYGTMFFVFFGLGAALRWTTGPHNVLQVAFCFGLAAATFIQSIGHISGGHINPAVTFAYLIGSQMSLFRAFFYICAQCLGALAGAAVLYGVTPTNMRGNLALNTLQPGISMGMATTIEIFLTLQLVVCVFAVTDERRNGRLGSAALSIGFSVLVGHLLGMYYTGAGMNPARSFAPAVLYRNFINHWVYWVGPMIGAAMGALLYDFMLFPRVRGLSERLAVLKGNKPTEPEAQQETRGEPIELKTQAL
Protein: Putative mitochondrial carnitine O-acetyltransferase (EC 2.3.1.7) (P80235)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol.
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Interaction partners:
- Carnitine O-acetyltransferase YAT2
- Carnitine O-acetyltransferase, mitochondrial
- Mitochondrial carnitine carrier
- Acetyl-coenzyme A synthetase 1
- Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
- Peroxisomal hydratase-dehydrogenase-epimerase
- Isocitrate lyase
- Citrate synthase, peroxisomal
- Succinate/fumarate mitochondrial transporter
Sequence:
MPNLKRLPIPPLQDTLNRYLARVEPLQDERQNRRTRRTVLSAENLDALNTLHERLLEYDARLAESNPESSYIEQFWYDAYLLYDATVVLNVNPYFQLQDDPTIKDTPETAAQGPYGAHTVQVRRAARLTTSILKFIRQIRHGTLRTDTVRGKTPLSMDQYERLFGSSRIPPGPGEPSCHLQTDATSHHVVAMYRGQFYWFDVLDTRNEPIFATPEQLEWNLYSIIMDAESAGSGSAPFGVFTTESRRVWSNIRDYLFHADDCTNWRNLKLIDSALFVVCLDDVAFAADQQDELTRSMLCGTSTINLDPHQHQPPLNVQTGTCLNRWYDKLQLIVTKNGKAGINFEHTGVDGHTVLRLATDIYTDSILSFARGVTKNVVDIFSDDDGKPSSSSLASAAHSANLITIPRKLEWRTDNFLQSSLHFAETRISDLISQYEFVNLDFSNYGASHIKTVFKCSPDAFVQQVFQVAYFALYGRFETVYEPAMTKAFQNGRTEAIRSVTGQSKLFVKSLLDQDASDATKIQLLHDACTAHSQITRECSQGLGQDRHLYALYCLWNQWYKDKLELPPIFRDKSWTTMQNNVLSTSNCGNPCLKSFGFGPVTANGFGIGYIIRDHSVSVVVSSRHRQTARFASLMEKSLLEIDRIFKRQQARAAKPAARTTASANTKSEDMKYLLSGYDYFDVSVSG
Protein: Protein kinase, putative (Q388C7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MESTDTEVTAQENPPTADVTHVDNKYIIHNDSVAGRGAWSVVKRCSVIDPYEPPSFQPGMKVVVKIIQKEYLLSLTKGNVERAMAEVKREIDVLRHIPSHGNVVTFLEYIETEEEFLLFFEEVQCGDLCEIILQAPEGKLSEETSKYYTYQIIKAVLHCHIHDVIHRDIKPENLLVSDDDNIKLTDFGLAKRSKGICTSAEERDALDPISLSMQYPGAERLIGKRIVCSDVIGTPRYGPPEMFYAKFTQTHYDGFKADTWSVGVVTYIMLSGSFPYSAAAHAPEKEVFRFIMDTTLPEPQGISPIAFDFIERLLNKDPHKRMSLNDALGHQWLEDVARPRQSVMVPKILETLPTPEVAQACKMFNKEAQALHQCITLLQRENQRLREAQERREESRATREKENRRTSTPRRAETPSTASRVGAGRAAGTSSSLRVTSPARTGVRPGRSSANESSNGSMSRPAGNRLTTRSPLARSAASTVRRGTPVRVAGATHSRTIGSTPMRSGTPSRTTTTGRSTSAARAGVSRLANSSLPVSHTSTRTTTPGRFGTRSTTPGRSAAVNHVSSAKDLHIGDIVTYKGFRAAVRFNGPTAFGAGIWIGLEMFEGNEGTNDGSSFIDKKQYFTCPKGKGVFVRASQVKKV
Protein: Anaphase-promoting complex subunit 11 (20S cyclosome/APC complex protein apc11) (Q9UT86)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.
Interaction partners:
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 3
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit cut9
- Anaphase-promoting complex subunit 4
- Mitotic spindle checkpoint component mad3
- Ubiquitin-conjugating enzyme E2-20 kDa
Sequence:
MKVKILRYHAIANWTWDTPKDDVCGICRVPFDGCCPQCTSPGDNCPIVWGKCKHIFHAHCIQNWLATSGSQGQCPMDRQTFVVADSTNEKSETQ
Protein: Ionotropic receptor 7a (Q9W3P8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Ionotropic receptor 67c
- Putative gustatory receptor 98c
- Putative gustatory receptor 36c
- Osiris 10a
- Putative gustatory receptor 59c
- Putative gustatory receptor 98b
- IP13856p
- Ionotropic receptor 25a
- Putative gustatory receptor 58c
- Probable cytochrome P450 316a1
Sequence:
MFHHLWLLMGLRSLAMGALHPPQPEAMTPLVAAALEILAEQVSPSQSTLAVMDLTQDAEHRDERQEQLMTIILRSVGSEMALRTFQKPPAEVPASFVVFLVNSAQAFNTLGFHFTDIHSTREFNFLILLTHRMSSRAERLQVLRDISRTCVRFHTSNVILLTEKRDGVVLVYAYRLLNMDCDLSVNLELIDIYKNGLFRHGHEARSFNRVLSLSGCPLQVSWYPLPPFVSFIGNSSDPEERAQIWRLTGIDGELIKLLASIFDFRILLEEPCNKCLSPDIKDDCSGCFDQVIISNSSILIGAMSGSHQHRSHFSFTSSYHQSSLVFIMHMSSQFGAVAQLAVPFTVIVWLALVVSSLLLVLVLWMRNRLVCGRSDLASHALQVLTTLMGNPLEARSLPRSSRLRILYAGWLLLVLVLRVVYQGKLFDSFRLPYHKPLPTEISELIRSNYTLINQEYLDYYPRELTVLTRNGSKDRFDYIQGLGKEGKFTTTSLIATMEYYNMMHWSTSRLTHIKEHIFLYQMVIYLRRHSLLKFAFDRKIKQLLSAGIIGYFVREFDACQYRKPFEEDYEVTPIPLDSFCGLYYISLIWLSAAVVAFILELLSQRIVWLRRIFE
Protein: Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] (P08037)
Organism: Bos taurus (Bovine)
Function: The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
Subcellular location: [Isoform Long]: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15535}; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cell surface. Cell projection, filopodium {ECO:0000250|UniProtKB:P15535}. Note=Found in trans cisternae of Golgi. B4GALT1 cell surface expression is regulated by UBE2Q1 (By similarity). {ECO:0000250|UniProtKB:P15535}.; SUBCELLULAR LOCATION: [Isoform Short]: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Found in trans cisternae of Golgi.; SUBCELLULAR LOCATION: [Processed beta-1,4-galactosyltransferase 1]: Secreted {ECO:0000305|PubMed:9405390}. Note=Soluble form found in body fluids. {ECO:0000269|PubMed:9405390}.
Interaction partners:
- Alpha-lactalbumin
- ST6 beta-galactoside alpha-2,6-sialyltransferase 1
- Alpha-
- Hexosyltransferase
- CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
- N-acetyllactosaminide alpha-1,3-galactosyltransferase
- 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
- Hexosyltransferase
- Type 2 lactosamine alpha-2,3-sialyltransferase
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
Sequence:
MKFREPLLGGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLRRLPQLVGVHPPLQGSSHGAAAIGQPSGELRLRGVAPPPPLQNSSKPRSRAPSNLDAYSHPGPGPGPGSNLTSAPVPSTTTRSLTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS
Protein: Cullin 2, isoform A (Cullin 2, isoform B) (LD36177p) (Q9V9R2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Elongin-B
- Elongin-C
- RING-box protein 1A
- Ubiquitin-like protein NEDD8
- RING-box protein 1B
- Protein fem-1 homolog B
- Protein Vhl
- Cullin-associated NEDD8-dissociated protein 1
- COP9 signalosome complex subunit 5
- GH06740p
Sequence:
MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKKSKTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLLNASSENLAGETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA
Protein: Zinc transporter ZIP12 (LIV-1 subfamily of ZIP zinc transporter 8) (LZT-Hs8) (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12) (Q504Y0)
Organism: Homo sapiens (Human)
Function: Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q5FWH7}; Multi-pass membrane protein {ECO:0000255}. Note=At low Zn(2+) extracellular concentration, is redistributed from the perinuclear space to the cytoplasm and plasma membrane. {ECO:0000250|UniProtKB:Q5FWH7}.
Interaction partners:
- Zinc transporter ZIP11
- Zinc transporter ZIP1
- Proton-coupled zinc antiporter SLC30A2
- Zinc transporter 6
- Zinc transporter ZIP2
Sequence:
MCFRTKLSVSWVPLFLLLSRVFSTETDKPSAQDSRSRGSSGQPADLLQVLSAGDHPPHNHSRSLIKTLLEKTGCPRRRNGMQGDCNLCFEPDALLLIAGGNFEDQLREEVVQRVSLLLLYYIIHQEEICSSKLNMSNKEYKFYLHSLLSLRQDEDSSFLSQNETEDILAFTRQYFDTSQSQCMETKTLQKKSGIVSSEGANESTLPQLAAMIITLSLQGVCLGQGNLPSPDYFTEYIFSSLNRTNTLRLSELDQLLNTLWTRSTCIKNEKIHQFQRKQNNIITHDQDYSNFSSSMEKESEDGPVSWDQTCFSARQLVEIFLQKGLSLISKEDFKQMSPGIIQQLLSCSCHLPKDQQAKLPPTTLEKYGYSTVAVTLLTLGSMLGTALVLFHSCEENYRLILQLFVGLAVGTLSGDALLHLIPQVLGLHKQEAPEFGHFHESKGHIWKLMGLIGGIHGFFLIEKCFILLVSPNDKQGLSLVNGHVGHSHHLALNSELSDQAGRGKSASTIQLKSPEDSQAAEMPIGSMTASNRKCKAISLLAIMILVGDSLHNFADGLAIGAAFSSSSESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMKTAILMNFISSLTAFMGLYIGLSVSADPCVQDWIFTVTAGMFLYLSLVEMLPEMTHVQTQRPWMMFLLQNFGLILGWLSLLLLAIYEQNIKI
Protein: Cofilin-1 (Cofilin, non-muscle isoform) (P10668)
Organism: Sus scrofa (Pig)
Function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
Subcellular location: Nucleus matrix {ECO:0000250|UniProtKB:P23528}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P23528}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:P23528}; Peripheral membrane protein {ECO:0000250|UniProtKB:P23528}; Cytoplasmic side {ECO:0000250|UniProtKB:P23528}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:P23528}; Peripheral membrane protein {ECO:0000250|UniProtKB:P23528}; Cytoplasmic side {ECO:0000250|UniProtKB:P23528}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P18760}. Cell projection, growth cone {ECO:0000250|UniProtKB:P18760}. Cell projection, axon {ECO:0000250|UniProtKB:P18760}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide. {ECO:0000250|UniProtKB:P23528}.
Interaction partners:
- LIM domain kinase 1.
- LIM domain kinase 2.
- Protein phosphatase Slingshot homolog 1
- Actin, cytoplasmic 1
- Actin gamma 1
- WASP like actin nucleation promoting factor
- Uncharacterized protein.
- Cofilin-2
- Hematopoietic lineage cell-specific protein
- Src substrate cortactin
Sequence:
MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPECAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL