wanglab/gogpt-training-data huggingface dataset:
Protein: IP16419p (Serpin 4) (Q7K8Y3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MADAAHQEFARRLALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGLASSDPEQIAHSFHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQKDLPLFWGSVVRLEENTFASSEHDEL
Protein: Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) (O35115)
Organism: Rattus norvegicus (Rat)
Function: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14192}. Nucleus {ECO:0000250|UniProtKB:Q14192}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:22851699}.
Interaction partners:
- Catenin beta-1
- TNF receptor-associated factor 6
- Lymphoid enhancer-binding factor 1
- TNF receptor-associated factor
- Titin
- Receptor protein-tyrosine kinase
Sequence:
MTERFDCHHCNESLYGKKYILKEENPHCVACFEELYANTCEECGTPIGCDCKDLSYKDRHWHEGCFHCSRCGSSLVDKPFAAKEEQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFTCQRCQQPIGTKSFIPKENQNFCVPCYEKQYALQCVQCKKPITTGGVTYRDQPWHRECFVCTACKKQLSGQRFTARDEFPYCLTCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI
Protein: Chitinase 1 (EC 3.2.1.14) (Q5AAH2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.
Subcellular location: Secreted {ECO:0000269|PubMed:12456000, ECO:0000269|PubMed:20641015}.
Interaction partners:
- Chitinase 4
- Beta-hexosaminidase
- Chitinase 2
- Chitinase 3
- chitin deacetylase
- Ngs1p
Sequence:
MILNLIILLAISIVASASNIAAYWGQNAGGDQQTLGDYCSSSPASIIILSFLDGFPNLSLNFANQCSGTFSSGLAHCSQIGSDIKSCQQQGKTILLSLGGATGNYGFSSDSEAVQFAGTLWNKFGGGKDSERPFDDAIVDGFDFDIENKDQTGYAALATQLRKYFSTGTKSYYLSAAPQCPYPDESVGDLMSQVDLDFAFIQFYNNYCSLNQQFNWNSWSNYARGKSIKLYLGLPGSSSSAGSGFVGLSTVQRVVASIKGDSSFGGISIWDISSAENGGYLNQLHQALSGSGSPAAPSNSYQPNTPLTRTYGGSTATASAYISVGFTAGATHGSTTTNDLLAWIDSLFGSSQSSVQQYATPVQSVTATPQPVAATTTSAPKPTASAFNWFGWFDGTTTSTTLQTVYSTVPADQTVYVTLTTTVGSQMLQSLFDKRDVIAEAKSTNLQICWLLFIPLLALICS
Protein: Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Q8K424)
Organism: Mus musculus (Mouse)
Function: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8NET8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NET8}. Cytoplasm {ECO:0000250|UniProtKB:Q8NET8}. Lysosome {ECO:0000250|UniProtKB:Q8NET8}. Note=Targeted to lysosome for degradation in a SNX11-dependent manner. {ECO:0000250|UniProtKB:Q8NET8}.
Interaction partners:
- Transient receptor potential cation channel subfamily M member 8
- Transient receptor potential cation channel, subfamily M, member 3.
- Transient receptor potential cation channel subfamily M member 1
- Hypoxia-inducible factor 1-alpha inhibitor
- Transient receptor potential cation channel subfamily A member 1
- Transient receptor potential cation channel subfamily M member 4
- Short transient receptor potential channel 5
- Ankyrin-1
- Transient receptor potential cation channel subfamily M member 7
- Short transient receptor potential channel 1
Sequence:
MNAHSKEMAPLMGKRTTAPGGNPVVLTEKRPADLTPTKKSAHFFLEIEGFEPNPTVTKTSPPIFSKPMDSNIRQCLSGNCDDMDSPQSPQDDVTETPSNPNSPSANLAKEEQRQKKKRLKKRIFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSREIKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEIIVYNTNIDNRHEMLTLEPLHTLLHTKWKKFAKYMFFLSFCFYFFYNITLTLVSYYRPREDEDLPHPLALTHKMSWLQLLGRMFVLIWATCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKCSKDKKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSTYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINEVKWTEWKTHVSFLNEDPGPIRRTADLNKIQDSSRSNSKTTLYAFDELDEFPETSV
Protein: mRNA export factor gle1 (Nuclear pore protein gle1) (Nucleoporin gle1) (RNA export factor gle1) (O94652)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus, nuclear pore complex {ECO:0000250}. Nucleus membrane {ECO:0000269|PubMed:16823372}; Peripheral membrane protein {ECO:0000269|PubMed:16823372}; Cytoplasmic side {ECO:0000269|PubMed:16823372}. Nucleus membrane {ECO:0000269|PubMed:16823372}; Peripheral membrane protein {ECO:0000269|PubMed:16823372}; Nucleoplasmic side {ECO:0000269|PubMed:16823372}.
Interaction partners:
- ATP-dependent RNA helicase dbp5
- Poly
- Nucleoporin nup146
- Probable nucleoporin C890.06
- mRNA export factor mex67
- Nucleoporin nup107
- Nucleoporin nsp1
- Nucleoporin nup44
- Nucleoporin seh1
- Nucleoporin nup85
Sequence:
MDTKTTPLIHAKLDEKIISSYNDANGLDIDDLWDIYNEKTRRMIHIISQRYKPKKQSPFPVIADENVRIFPPLHKTIDWAKKRNVEEQNLIEQSITESQRIFSEKQRLEQERFNRELLEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQKHKENEQRRLKQEQIDAKRKEEEAREKRMKETFKDDPEEDSNMAWSIIHKIKTEVVAPISEKKELKNYCFTQKRKITPRLGQITKSNSQIMKITQLLQQTFQEARNTDPLVYKWVLNFFCKSVVKQAEAEVAVNPISAYPLAKVCLLLQTQNADLKDLLFARLQKNCPWVIPFWYDHGTENGKKKMGFKKLSDGHWEQNTTYNERQCGIFAVYAAILSLDDSLAPESWRTFSRLLNLPSPSQLMKSDLELGQTLCSIVSTYLDIAGQSLLRIYGRQAKKLIVCSFSEAYLGANGGGSQYGRLRIVGEDWMKGQGGLKFSFEP
Protein: Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase zeta) (DGK-zeta) (Q80UP3)
Organism: Mus musculus (Mouse)
Function: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (By similarity). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol. By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (By similarity). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane. Regulates RASGRP1 activity (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:20023381}. Cytoplasm, cytosol {ECO:0000305|PubMed:20023381}. Cell membrane {ECO:0000250|UniProtKB:Q13574}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q13574}.
Interaction partners:
- Sorting nexin-27
- Lipoprotein lipase
- Dihydroxyacetone phosphate acyltransferase
- Disks large homolog 4
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- Phospholipase D1
- Phospholipase D2
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Phosphatidate cytidylyltransferase 2
- Rho GDP-dissociation inhibitor 1
Sequence:
MEPRDPSPEGRSSDSESASASSSGSERDAGPEPDKAPRRLTKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCGESEEQIQSTVDWSESAVYGEHIWFETNVSGDFCYVGEQHCVAKMLPKSAPRKKCAACKIVVHTQCIKQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMMQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLSASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQREPDGAGAKSPMCHQLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSMQGDTALPQGEELIEAAKRNDCCKLQELHRAGGDLMHRDQKSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDLQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
Protein: Uncharacterized protein (Q385H9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MATARSYFYYLDAHGNLFPVTDIKGLIDGTNIPAGPIQLRDRAFLDFFYLRLKRSDVEDAAACSNVSDRREEGELLLHSGAKLTPQEVVQHFPYVSICGPERNFLKAEEAPLVFVNYTSGHPKCKQQNGTLAFGESLWEDFQPQALVVTREGKLFHPITKLKNLIATQNGAGDAVPRGLVEAQVVKKLGLELVCDSAKSGYYVLEWKGQKQRIPYFDEL
Protein: Eukaryotic translation initiation factor 3 subunit K (eIF3k) (eIF-3 p25) (Q9XUP3)
Organism: Caenorhabditis elegans
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03010}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit E
- COP9/Signalosome and eIF3 complex-shared subunit 1
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit B
Sequence:
MSFEKLQKELHEAIEGVNRYNPENVADLAACVQAMVNENKYDKDIVLTILKLYQLNPEKYDEAVVRQVLLKTLMVLPSSDFALAKCLIDTNRLGSQELRRIFDLGAVLESCNFAVFWKLVKGAYKPTTNPNEPFKVPGEVPKMIKPMVGFEDAVKHYACRVISVTFQKIEKKMLSRLLGGASDKEVTALAQSFGWEAKENGDVFFVANHEGTIKTRNIDEKIQFPHVADLLTSIQPPLTL
Protein: Zinc finger containing ubiquitin peptidase 1 (X6R6X3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLSCNICGETVTSEPDMKAHLIVHMESEIICPFCKLSGVNYDEMCFHIETAHFEQNTLERNFERINTVQYGTSDNKKDNTLQCGMEVNSSILSGCASNHPKNSAQNLTKDSTLKHEGFYSENLTESRKFLKSREKQSSLTEIKGSVYETTYSPPECPFCGKIEEHSEDMETHVKTKHANLLDIPLEDCDQPLYDCPMCGLICTNYHILQEHVDLHLEENSFQQGMDRVQCSGDLQLAHQLQQEEDRKRRSEESRQEIEEFQKLQELLKHFIGIIRMLPQM
Protein: PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b) (Q8C437)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Some fraction is membrane associated via its interaction with RAB8B. {ECO:0000250}.
Interaction partners:
- Peroxisomal targeting signal 2 receptor
- Peroxisomal membrane protein PEX14
- Sterol carrier protein 2
- Peroxisome assembly protein 12
- Peroxisomal targeting signal 1 receptor
- Ras-related protein Rab-8B
- Peroxisomal membrane protein PEX13
- 2-hydroxyacyl-CoA lyase 1
- Peroxisome biogenesis factor 10
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Sequence:
MYQGHMQLVNEQQESRPLLSPSIDDFLCETKSEAIAKPVTSNTAVLTTGLDLLDLSEPVSQPQTKAKKSEPSSKSSSLKKKADGSDLISADAEQRAQALRGPETSSLDLDIQTQLEKWDDVKFHGDRTSKGHLMAERKSCSSRTGSKELLWSAEHRSQPELSTGKSALNSESASELELVAPAQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTVSASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTSHQQDACEALKNWIKQNPKYKYLVKNKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP
Protein: Uncharacterized protein (Q386Z7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRRGGPTRTPTLPWANITALREAKREEEGSTIDSKPQQTTNTSGNAQRLKAMPKIGVARIGVHRVGIERNCATASEDGTKGLRFDGKERHESCNISGSSVGCMDLLEFTVAKERECVNLKNMMRQWADVFSRSSGCFVLREIVLKCNNMAPILPDLITSCFSLMEQELCGRELVAEPTHFVSCFLRREYEVKLGPIKMKTVELSHNYASLEEGGKYLRICLNLRRIVLETLSYSYRNAKNKSADFTHGTVDLKVENCALKVDLIILLAGGGFVTIYRRCDNLKIGSIGADFSGFIPNLIFFIIKPIIRRSLRNQIMAVMNERTFGKT
Protein: 2-deoxyglucose-6-phosphate phosphatase 2 (2-DOG-6-P 2) (2-deoxyglucose-6-phosphatase 2) (EC 3.1.3.68) (P38773)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Phosphatase that is active on 2-deoxy-D-glucose 6-phosphate (2-DOG-6P), but not very active on fructose-1-P.
Interaction partners:
Sequence:
MPQFSVDLCLFDLDGTIVSTTTAAESAWKKLCRQHGVDPVELFKHSHGARSQEMMKKFFPKLDNTDNKGVLALEKDMADNYLDTVSLIPGAENLLLSLDVDTETQKKLPERKWAIVTSGSPYLAFSWFETILKNVGKPKVFITGFDVKNGKPDPEGYSRARDLLRQDLQLTGKQDLKYVVFEDAPVGIKAGKAMGAITVGITSSYDKSVLFDAGADYVVCDLTQVSVVKNNENGIVIQVNNPLTRD
Protein: Mitochondrial import inner membrane translocase subunit Tim10B (Mitochondrial import inner membrane translocase subunit Tim9B) (Tim-10b) (Tim10b) (Q9Y0V2)
Organism: Caenorhabditis elegans
Function: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:15485840}; Peripheral membrane protein {ECO:0000269|PubMed:15485840}.
Interaction partners:
- Ribosome maturation protein SBDS
- Mitochondrial import inner membrane translocase subunit Tim10
- Mitochondrial import inner membrane translocase subunit Tim8
- Mitochondrial import receptor subunit TOM7 homolog
Sequence:
MNTIQNIQQLREFLTVYNTLSERCFNACARDYTTSTLTKDEGSCVSQCIDKQMLVNRRFMLVFAEQAPKALFKQGEQSPTEAIKSAKPEPAVPAPEATPVETTPVIEENKQ
Protein: Nitrogen fixation regulatory protein (EC 2.7.13.3) (P30663)
Organism: Azotobacter vinelandii
Function: Required for the inhibition of NifA activity in response to oxygen and low level of fixed nitrogen.
Interaction partners:
Sequence:
MTPANPTLSNEPQAPHAESDELLPEIFRQTVEHAPIAISITDLKANILYANRAFRTITGYGSEEVLGKNESILSNGTTPRLVYQALWGRLAQKKPWSGVLVNRRKDKTLYLAELTVAPVLNEAGETIYYLGMHRDTSELHELEQRVNNQRLMIEAVVNAAPAAMVVLDRQHRVMLSNPSFCRLARDLVEDGSSESLVALLRENLAAPFETLENQGSAFSGKEISFDLGGRSPRWLSCHGRAIHIENEQAHVFFAPTEERYLLLTINDISELRQKQQDSRLNALKALMAEEELLEGMRETFNAAIHRLQGPVNLISAAMRMLERRLGDKAGNDPVLSAMREASTAGMEALENLSGSIPVRMAESKMPVNLNQLIREVITLCTDQLLAQGIVVDWQPALRLPWVMGGESSQRSMIKHLVDNAIESMSQNQVSRRELFISTRVENHLVRMEITDSGPGIPPDLVLKVFEPFFSTKPPHRVGRGMGLPVVQEIVAKHAGMVHVDTDYREGCRIVVELPFSAST
Protein: Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) (Q80W65)
Organism: Mus musculus (Mouse)
Function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
Subcellular location: Cytoplasm {ECO:0000250}. Secreted. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cell surface {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and co-localizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity). {ECO:0000250}.
Interaction partners:
- Very low-density lipoprotein receptor
- Apolipoprotein B-100
- Low-density lipoprotein receptor
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Sterol regulatory element-binding protein 2
- Pro-epidermal growth factor
- Sortilin
- Low-density lipoprotein receptor-related protein 8
- Scavenger receptor class B member 1
- Epidermal growth factor receptor
Sequence:
MGTHCSAWLRWPLLPLLPPLLLLLLLLCPTGAGAQDEDGDYEELMLALPSQEDGLADEAAHVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVIKVLHIFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQSIPWNLERIIPAWHQTEEDRSPDGSSQVEVYLLDTSIQGAHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNAACRHLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCFMSQSGTSQAAAHVAGIVARMLSREPTLTLAELRQRLIHFSTKDVINMAWFPEDQQVLTPNLVATLPPSTHETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDWIEAIGGQQVCKALNAFGGEGVYAVARCCLVPRANCSIHNTPAARAGLETHVHCHQKDHVLTGCSFHWEVEDLSVRRQPALRSRRQPGQCVGHQAASVYASCCHAPGLECKIKEHGISGPSEQVTVACEAGWTLTGCNVLPGASLTLGAYSVDNLCVARVHDTARADRTSGEATVAAAICCRSRPSAKASWVQ
Protein: Arabinose 5-phosphate isomerase KpsF (API) (EC 5.3.1.13) (K-antigen-specific arabinose 5-phosphate isomerase) (K-API) (Q8FDQ2)
Organism: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Function: Involved in the biosynthesis of K-antigen capsules. Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P).
Interaction partners:
- 2-dehydro-3-deoxyphosphooctonate aldolase
- Arabinose 5-phosphate isomerase KdsD
- arabinose-5-phosphate isomerase
- 3-deoxy-manno-octulosonate cytidylyltransferase
- 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
- 3-deoxy-manno-octulosonate cytidylyltransferase
- 3-deoxy-D-manno-octulosonic acid transferase
- KpsS protein
- Capsule polysaccharide export inner-membrane protein KpsE
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Sequence:
MSERHLPDDQSSTIDPYLITSVRQTLAEQSAALQNLSKQLDSGQYQRVLNLIMNCKGHVILSGMGKSGHVGRKISATLASTGTPSFFIHPAEAFHGDLGMITPYDLLILISASGETDEILKLVPSLKNFGNRIIAITNNGNSTLAKNADAVLELHMANETCPNNLAPTTSTTLTMAIGDALAIAMIHQRKFMPNDFARYHPGGSLGRRLLTRVADVMQHDVPAVQLDASFKTVIQRITSGCQGMVMVEDAEGGLAGIITDGDLRRFMEKEGSLTSATAAQMMTREPLTLPEDTMIIEAEEKMQKHRVSTLLVTNKANKVTGLVRIFD
Protein: Probable leucine-rich repeat receptor-like protein kinase At2g28990 (EC 2.7.11.1) (O81069)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Ammonium transporter 1 member 1
- Classical arabinogalactan protein 27
- Cation/H
Sequence:
MKIHLLLAMIGTFVVIIGAQDQEGFISLDCGLPSDESPYDDSFNGLTFTSDSTFIQTGKIDSVDKDLNINLSKQYLTLRYFPEGKRNCYSLDVKRGTTYLIVVSFVYGNYDGLNRDPNFDIHLGPNKWKRIDLDGEKEGTREEIIHKARSNSLDICLVKTGETLPIISAIEIRPLRNNTYVTQSGSLMMSFRVYLSNSDASIRYADDVHDRIWSPFNGSSHTHITTDLNINNSNAYEIPKNILQTAAIPRNASAPLIITWDPLPINAEVYLYMHFAEIQTLEANETRQFDVILRGNFNHSGFSPTKLKVFTLYTEEPMKCGSEGCYLQLVKTPNSTLPPLINAIEAYSVIEFSQLETSLSDVDAIKNIKNTYKLNKITWQGDPCLPQDLSWESIRCTYVDGSTSPTIISLDLSKSGLNGSIPQILQNFTQLQELDLSNNSLTGPVPIFLANMKTLSLINLSGNNLSGSVPQALLDKEKEGLVLKLEGNPDLCKSSFCNTEKKNKFLLPVIASAASLVIVVVVVALFFVFRKKKASPSNLHAPPSMPVSNPGHNSQSESSFTSKKIRFTYSEVQEMTNNFDKALGEGGFGVVYHGFVNVIEQVAVKLLSQSSSQGYKHFKAEVELLMRVHHINLVSLVGYCDEGEHLALIYEYMPNGDLKQHLSGKHGGFVLSWESRLKIVLDAALGLEYLHTGCVPPMVHRDIKTTNILLDQHLQAKLADFGLSRSFPIGNEKNVSTVVAGTPGYLDPEYYQTNWLTEKSDIYSFGIVLLEIISNRPIIQQSREKPHIVEWVSFMITKGDLRSIMDPNLHQDYDIGSVWKAIELAMSCVSLSSARRPNMSRVVNELKECLISETSRIGEGRDMESKGSMEFSRDIYNEVIPQAR
Protein: Tubulin beta-6 chain (Beta-6-tubulin) (P29514)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Tubulin alpha-6 chain
- Tubulin alpha-2 chain
- Microtubule-associated protein RP/EB family member 1B
- Tubulin alpha-5 chain
- Tubulin alpha-1 chain
- Microtubule-associated protein RP/EB family member 1A
- 65-kDa microtubule-associated protein 2
- CLIP-associated protein
- Microtubule-associated protein RP/EB family member 1C
- Mitotic spindle checkpoint protein MAD2
Sequence:
MREILHIQGGQCGNQIGSKFWEVVCDEHGIDPTGRYVGNSDLQLERVNVYYNEASCGRYVPRAILMDLEPGTMDSVRTGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDAVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDSKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIAPRGLSMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADDEGEYEEDEDEEEILDHE