wanglab/gogpt-training-data huggingface dataset:
Protein: Galactokinase (EC 2.7.1.6) (Galactose kinase) (Q59VY8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Bifunctional protein GAL10
- Galactose-1-phosphate uridylyltransferase
- Gal102p
- Orotidine 5'-phosphate decarboxylase
- N-
- Oxidoreductase
- D-xylose 1-dehydrogenase
- beta-mannosidase
Sequence:
MSVPTFDDLSFYSNDQELTKSRYLKLVEIFQSNFPNASIDFFARSPGRVNLIGDHIDYNFFPVLPMAISNDVIVAVNVNDEPEIVITNTDSKNFAKETIPLTNNNDGFEIDSQHHSWANYFKCALIVANNYLTEQNLKGQLKGMKLTFDGNVPTGGGLSSSAAFCVASTLAILHANGVKDISKADLTRITVVCEHYVGVNTGGMDQCASVYGEPDKALLIQFKPKLIGKPFKFPVENLTFVITNSLQVSNKHETAPIHYNLRVVEMAIAADVLVKKLNLGTLVPQDSNIGTSSLRGVMDAVFNTCKWDGNDIDVGIDQLKKMIAIVETELNNNQEGYTVDQCLTVLDLSLDEFKSKYLQAYPVKFDVLKLYQRAKHVYQESLRVLETLKLLSTTQTSSNSKDDDESFLVKFGELMNQSQSDLDKLNESSNDKLNEICSIALQNGSYGSRITGAGWGGSIVHLTTLDKSKQLIQGLIKNYYQLEFPNIKLDELLNDAIIDSKPSMGSCIVTTKFLQ
Protein: alanine transaminase (EC 2.6.1.2) (Q7KV27)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSRMLIKPAAATVSAALQQHQRQQQQYVIRRWKSFLHNNSNNANRRAAKSTATATVTAAATSQRHGTSGDFIQPLDVRRSFSTSHKMPSSSKALTLDNINPNFIAMEYAVRGPLVIRAGEIEKELEKGVKKPFDQVIRANIGDCHAMGQQPLTFLRQLLALTFETRLLDSPDYPEDVKKRACAILNGCQGQSVGSYTDSAGLEVVRRQVAQYIEKRDGGIASNWQDIYLTGGASPGIKSILSMINAEVGCKAPGVMVPIPQYPLYSATISEYGMTKVDYYLEEETGWSLDRKELQRSYDEAKKVCNPRALVVINPGNPTGQVLTRENIEEIIKFAHDNKVLVLADEVYQDNVYDKNSKFWSFKKVAYEMGDPYRNLEMVSFLSTSKGYLGECGIRGGYMEVLNLDPKVKAMLTKSITAALCSTTAGQVAVSALVNPPQPGEPSYDLYKKERDGILAALKERAELVHKALNSFEGYKVNPVQGAMYVFPQIEIPPKAIEAAKAKGMAPDVFYAFELLETSGICIVPGSGFGQKPGTWHFRSTILPQTDKLKLMMEKFRVFHAEFMKKYK
Protein: Hepatitis A virus cellular receptor 1 homolog (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (CD antigen CD365) (O54947)
Organism: Rattus norvegicus (Rat)
Function: Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (By similarity). Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q96D42}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q96D42}.
Interaction partners:
- Neutrophil gelatinase-associated lipocalin
- Cystatin-C
- Clusterin
- Protein O-GlcNAcase
- Albumin
- Fatty acid-binding protein, liver
- Beta-2-microglobulin
- Nephrin
Sequence:
MVQLQVFISGLLLLLPGSVDSYEVVKGVVGHPVTIPCTYSTRGGITTTCWGRGQCPYSSCQNILIWTNGYQVTYRSSGRYNIKGRISEGDVSLTIENSVDSDSGLYCCRVEIPGWFNDQKMTFSLEVKPEIPTSPPTRPTTTRPTTTRPTTISTRSTHVPTSTRVSTSTPTPEQTQTHKPEITTFYAHETTAEVTETPSYTPADWNGTVTSSEEAWNNHTVRIPLRKPQRNPTKGFYVGMSVAALLLLLLASTVVVTRYIIIRKKMGSLSFVAFHVSKSRALQNAAIVHPRAEDNIYIIEDRSRGAE
Protein: Glutathione S-transferase D4 (EC 2.5.1.18) (Q9VG96)
Organism: Drosophila melanogaster (Fruit fly)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May be involved in detoxification.
Interaction partners:
- Glutathione S-transferase D2
- Glutathione S-transferase D7
- Glutathione S-transferase D6
- Glutathione S transferase D10, isoform A
- Glutathione S-transferase D5
- Glutathione S-transferase D1
- Bifunctional glutamate/proline--tRNA ligase
- Glutathione S transferase D9, isoform A
- Glutathione S transferase O1
- Glutathione S transferase E11, isoform A
Sequence:
MDFYYSPRSSGSRTIIMVAKALGLELNKKQLRITEGEHLKPEFLKLNPQHTIPTLVDNGFAIWESRAIAVYLVEKYGKDDSLFPNDPQKRALINQRLYFDMGTLHDSFMKYYYPFIRTGQLGNAENYKKVEAAFEFLDIFLEGQDYVAGSQLTVADIAILSSVSTFEVVEFDISKYPNVARWYANAKKITPGWDENWKGLLQMKTMYEAQKASLK
Protein: L-cysteine S-thiosulfotransferase subunit SoxA (EC 2.8.5.2) (Cytochrome c550 subunit monoheme) (Protein SoxA) (SoxAX cytochrome complex subunit A) (Sulfur oxidizing protein A) (Thiosulfate-oxidizing multienzyme system protein SoxA) (TOMES protein SoxA) (Q1W3E4)
Organism: Allochromatium vinosum (Chromatium vinosum)
Function: C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells.
Subcellular location: Periplasm {ECO:0000250|UniProtKB:Q8KDM7}.
Interaction partners:
Sequence:
MTKHGFLLATLVLAGATLPIGPVTAATPEEEQAAFQAYFKQRFPNVPEDEFKNGTYAIDPVTRENWEAIEEFPPYENAISQGETLWNTPFADGQGYADCFPDGPAIMNHYPRWDRERGQVMTLPLALNACRTAHGETPLKYKKGPIADLLAYIAFESRGQITRVEIPQDDPRALAAYEQGKRFYFARRGQLNFACAHCHLATSGTKLRTETLSPAYGHTTHWPVYRSEWGEMGTLHRRFAGCNEQVRAKAFEPQGEEYRNLEYFLTYMNNGLELNGPGARK
Protein: Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) (Q9NTJ3)
Organism: Homo sapiens (Human)
Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular location: Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Interaction partners:
- Condensin complex subunit 2
- Condensin complex subunit 1
- Condensin complex subunit 3
- Condensin-2 complex subunit G2
- Structural maintenance of chromosomes protein 2
- Condensin-2 complex subunit H2
- Condensin-2 complex subunit D3
- Double-strand-break repair protein rad21 homolog
- Kinesin-like protein KIF11
- Cyclin-dependent kinase 1
Sequence:
MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEEILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVAVNPKEIASKGLC
Protein: RNA-binding protein involved in heterochromatin assembly dri1 (Dpb4-interacting, RRM, and IDR-containing factor) (O13801)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mediates heterochromatin assembly by promoting RNAi-mediated heterochromatin silencing and histone deacetylation. Binds pericetromeric transcripts and recruits the RNA-induced transcriptional silencing (RITS) complex to heterochromatin. Recruits sir2 to chromatin to promote deacetylation of 'Lys-9' of histone H3.
Subcellular location: Chromosome {ECO:0000269|PubMed:33693625}. Nucleus {ECO:0000269|PubMed:33693625}. Cytoplasm {ECO:0000269|PubMed:33946513}. Cytoplasmic granule {ECO:0000269|PubMed:33946513}. Note=Dri1 is dynamically shuttled between the nucleus and the cytoplasm and exported from the nucleus through the Rae1-dependent mRNA export pathway. Localizes to the cytoplasm throughout the cell cycle. Upon mild heat stress, a portion of DRI1 assembles into protein aggregate centers (PACs), sequestering it into the cytoplasmic aggregates and limiting cell division at high temperatures. {ECO:0000269|PubMed:33946513}.
Interaction partners:
- ATP-dependent RNA helicase dbp4
- Protein psi1
Sequence:
MPLPESVGDLVVLHFETNLDDHGISIGRAPCEIHEICWVILDGKTLEKQHCESCSIREDSSRHGICGSASSLTEAIFTLDNSIQERLNFQGKPFTFVVMNGRELRVLLPKEARDQGITLPSYMRHPRLFDLSSEYAKWQIRMGAVPPYTITLSHIFGKLDVDSLPPITESKAIELSPSDAPYITKGLTQCWRLANATTLLLRKAEKDSRGHSLPSVLTQPINCQADARSFYAERSKIVHVAGLTNDVTQLELESWFTNHGVHPVALWTLKTPEPYKSTGTGFVLFASHEDAADALAFNGYCLGDRMLEIIPSSTKVLDKASDILIPFPSSKNRPRPGDWNCPMCGFSNFQRRTSCFRCSFPGPTHVSAATGSNTFSPDFPYGNSYGNGSSHFIANYGGSVHHSNENTMQSDLQHQNGNNAVNHHHSSRSFGGNVPFRAGDWKCGSEGCGYHNFAKNVCCLRCGASRATAAVVADHASGPVNGSYSHNSYSHIPPVMSTSPPNHSVYPYSQLSINSVTANHGQNFGGQNGGNVSRFDDHGRFKEVSRPSVTTDQGDWLCECGFTNFRRRSNCLRCNAPHYSNMQIPASLPSDFNAYV
Protein: DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-) (P19822)
Organism: Escherichia phage T5 (Enterobacteria phage T5)
Function: Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'-5' direction for proofreading purpose. The DNA synthesis very likely occurs by strand displacement.
Interaction partners:
Sequence:
MKIAVVDKALNNTRYDKHFQLYGEEVDVFHMCNEKLSGRLLKKHITIGTPENPFDPNDYDFVILVGAEPFLYFAGKKGIGDYTGKRVEYNGYANWIASISPAQLHFKPEMKPVFDATVENIHDIINGREKIAKAGDYRPITDPDEAEEYIKMVYNMVIGPVAFDSETSALYCRDGYLLGVSISHQEYQGVYIDSDCLTEVAVYYLQKILDSENHTIVFHNLKFDMHFYKYHLGLTFDKAHKERRLHDTMLQHYVLDERRGTHGLKSLAMKYTDMGDYDFELDKFKDDYCKAHKIKKEDFTYDLIPFDIMWPYAAKDTDATIRLHNFFLPKIEKNEKLCSLYYDVLMPGCVFLQRVEDRGVPISIDRLKEAQYQLTHNLNKAREKLYTYPEVKQLEQDQNEAFNPNSVKQLRVLLFDYVGLTPTGKLTDTGADSTDAEALNELATQHPIAKTLLEIRKLTKLISTYVEKILLSIDADGCIRTGFHEHMTTSGRLSSSGKLNLQQLPRDESIIKGCVVAPPGYRVIAWDLTTAEVYYAAVLSGDRNMQQVFINMRNEPDKYPDFHSNIAHMVFKLQCEPRDVKKLFPALRQAAKAITFGILYGSGPAKVAHSVNEALLEQAAKTGEPFVECTVADAKEYIETYFGQFPQLKRWIDKCHDQIKNHGFIYSHFGRKRRLHNIHSEDRGVQGEEIRSGFNAIIQSASSDSLLLGAVDADNEIISLGLEQEMKIVMLVHDSVVAIVREDLIDQYNEILIRNIQKDRGISIPGCPIGIDSDSEAGGSRDYSCGKMKKQHPSIACIDDDEYTRYVKGVLLDAEFEYKKLAAMDKEHPDHSKYKDDKFIAVCKDLDNVKRILGA
Protein: At1g16880 (F6I1.15 protein) (Transmembrane protein) (Q9FE54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At4g39675
- At1g11210)
- Protein COLD-REGULATED 15B, chloroplastic
- AT-hook motif nuclear-localized protein 17
- At2g44380
- Dehydrin Xero 2
- BURP domain protein USPL1
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Glycine-rich RNA-binding protein 4, mitochondrial
Sequence:
MAEKVKSGQVFNLLCIFSIFFFLFVLSVNVSADVDSERAVPSEDKTTTVWLTKIKRSGKNYWAKVRETLDRGQSHFFPPNTYFTGKNDAPMGAGENMKEAATRSFEHSKATVEEAARSAAEVVSDTAEAVKEKVKRSVSGGVTQPSEGSEEL
Protein: 3beta-hydroxysteroid dehydrogenase (Q54TU9)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Putative methylsterol monooxygenase DDB_G0269788
- Probable lanosterol 14-alpha demethylase
- Small ribosomal subunit protein eS30
- Squalene synthase
- Cycloartenol synthase
- Protein erg2 homolog
Sequence:
MSKSYLVVGGCGFLGRYIVESLLARGEKNVHVFDIRKSFEDDRVTFHIGDIRKTEDLESACKGITTVFHTASPTHGMGYDIYYSVNVIGTERLIEACIKCGVKQLVYTSSSSVVFNGKDIVNGDETLPYVDKHIDPYNKTKELGERAVLKAKGSNLLVCALRPAGIFGPREVQGWPQFLKAAKEGKNKFMFGDGNNLCDWTYIDNVVHAHILAADNMTTNSPISGSVYFITNDEPIPFWDMPIFAYEAFGYERPKMKIPFTIMYCIAWMIDLITLLLSPFVKLHPTISLFRIIYTNSTRYFNIEKAKKELKYKPIVSLRDGMEKTKEWFLQQNPSFINKSKETSKLLKK
Protein: Histone H2B.2 (P02294)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H2A.2
- Histone H3
- Histone H2A.Z
- Histone H2A.1
- Histone H4
- Histone H2B.1
- FACT complex subunit SPT16
- Histone H3-like centromeric protein CSE4
- Histone H1
- FACT complex subunit POB3
Sequence:
MSSAAEKKPASKAPAEKKPAAKKTSTSVDGKKRSKVRKETYSSYIYKVLKQTHPDTGISQKSMSILNSFVNDIFERIATEASKLAAYNKKSTISAREIQTAVRLILPGELAKHAVSEGTRAVTKYSSSTQA
Protein: Transcription factor (B5DF82)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796}.
Interaction partners:
Sequence:
MIISTPQRITNSGSVLIGSPYTPAPAMVTQTHIAEAAGWVPSDRKRAREFIDSDFSESKRSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVSEFTNASNHLAADSAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEIEKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPAVNSTIQLPFIVINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKIAKSLVPKALEGYITDVSTGPSWLNQGLLLNSTQSVSNLDPTTGATVPQSSVNQGLCLDAEVALATGQFLAPNSHQSSTAASQFSESRGETPCSFNDEEEEDEEEDPSSPE
Protein: Serine/threonine-protein phosphatase BSL3 (EC 3.1.3.16) (BSU1-like protein 3) (Q9SHS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphatase involved in elongation process, probably by acting as a regulator of brassinolide signaling.
Subcellular location: Nucleus {ECO:0000269|PubMed:19245862}.
Interaction partners:
- Serine carboxypeptidase 24
- Serine/threonine-protein phosphatase 4 regulatory subunit-like protein
- Proline-rich extensin-like protein EPR1
- Shaggy-related protein kinase epsilon
- At2g30880/F7F1.9
- Serine/threonine-protein kinase BSK1
Sequence:
MDLDSSMVPENDQDPIATSENQSPMEEKEEASEQQTGSESESASLTPSLPPPSQQQQQQQQQPQVTAVVGPRCAPTYSVVNAIIEKKEDGPGPRCGHTLTAVPAVGEEGTSSYIGPRLILFGGATALEGNSGGTGTPTSAGSAGIRLAGATADVHCYDVLSNKWSRLTPYGEPPSPRAAHVATAVGTMVVIQGGIGPAGLSAEDLHVLDLTQQRPRWHRVVVQGPGPGPRYGHVMALVGQRYLMAIGGNDGKRPLADVWALDTAAKPYEWRKLEPEGEGPPPCMYATASARSDGLLLLCGGRDANSVPLASAYGLAKHRDGRWEWAIAPGVSPSARYQHAAVFVNARLHVSGGALGGGRMVEDSSSVAVLDTAAGVWCDTKSVVTSPRTGRYSADAAGGDASVELTRRCRHAAAAVGDLIFIYGGLRGGVLLDDLLVAEDLAAAETTSAASHAAAAAAATNTPPGRSPGRYGFSDERTGELPESAPDAVVLGSPVAPPVNGDMYTDISTENAMVPGIRRTSKGVEYLVEASAAEAEAISATLAAAKARQVNGEVELPDRDRGAEATPSGKPSLSLIKPDSAVPNSVIPAGVRLHHRAVVVAAETGGALGGMVRQLSIDQFENEGRRVSYGTPESATAARKLLDRQMSINSVPKKVVAHLLKPRGWKPPVRRQFFLDCNEIADLCDSAERIFSSEPTVLQLKAPIKIFGDLHGQFGDLMRLFDEYGSPSTAGDISYIDYLFLGDYVDRGQHSLETITLLLALKVEYQHNVHLIRGNHEAADINALFGFRIECIERMGERDGIWVWHRINRLFNWLPLAALIEKKIICMHGGIGRSINHVEQIENIQRPITMEAGSIVLMDLLWSDPTENDSVEGLRPNARGPGLVTFGPDRVMEFCNNNDLQLIVRAHECVMDGFERFAQGHLITLFSATNYCGTANNAGAILVLGRDLVVVPKLIHPLPPAITSPETSPERHIEDTWMQELNVNRPPTPTRGRPQNPNDRGSLAWI
Protein: Holliday junction resolvase RecU (EC 3.1.21.10) (P39792)
Organism: Bacillus subtilis (strain 168)
Function: Has at least 2 separable functions; Holliday junction resolution with generation of monomeric chromosomes, and modulation of RecA activity. Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. Partially inhibits the hydrolysis of dATP or rATP by RecA. Holliday junction resolution is stimulated by RuvB.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Regulatory protein RecX
- Holliday junction branch migration complex subunit RuvA
- DNA replication and repair protein RecF
- Single-stranded-DNA-specific exonuclease RecJ
- DNA repair protein RecO
- ATP-dependent DNA helicase RecG
- Protein RecA
- Penicillin-binding protein 1A/1B
- Probable ATP-dependent DNA helicase RecS
- Holliday junction branch migration complex subunit RuvB
Sequence:
MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNKYYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEAKETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKEKNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG
Protein: Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (BBC1 protein homolog) (P41126)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (Probable).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:23636399}.
Interaction partners:
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein eL8
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS11A
- Large ribosomal subunit protein eL43
- 40S ribosomal protein S24
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL20
- Ubiquitin-ribosomal protein eL40 fusion protein
- Small ribosomal subunit protein eS4
Sequence:
MGKGNNMIPNQHYHKWWQRHVKTWFNQPARKVRRHANRVKKAKAVFPRPASGALRPVVRCPTIRYHTKLRAGRGFTLEELKGAGIGANFAKTIGIAVDRRRKNKSLESRQRNIQRLKEYRSKLILFPINEKKIRAGESSLEECKLATQLKGPVLPIKNEQPAVVEFREVTKDEKKFKAFATLRKARTDARLVGIRAKRAKEAAESEDAAKGDPKKAKK
Protein: Nuclear RNA export factor 1 (Q9XVS7)
Organism: Caenorhabditis elegans
Function: Involved in RNA export from the nucleus to the cytoplasm.
Subcellular location: Nucleus. Note=Shuttle protein that accumulates in the nucleoplasm and at the nuclear rim.
Interaction partners:
- NTF2-related export protein
- mRNA export factor rae-1
- Nsp1_C domain-containing protein
- THO complex subunit 5
- Nuclear cap-binding protein subunit 2
- Chromatin target of PRMT1 protein C-terminal domain-containing protein
- Nuclear cap-binding protein subunit 1
- THO complex subunit 2
- Chromatin target of PRMT1 protein C-terminal domain-containing protein
- RRM domain-containing protein
Sequence:
MERDGCFGNCWLRRWEKSDMNRKGFGGHRDAKQLSRTKNRFARLDPDTQSRYEDDDEPAVPVRASLTSASSRGRGGSSRGFGQSAASIANTGVRNADIVYKCRATGAAKKVDAKWLIKQLNQIIENFKPLLWTDNARGDFEWYVRDEDTASTIRANNRRVVHKESGTRVEFYTSKVPAPWMKLKREEIEIIHRVVDKRHNAENRVLDLSNFHEDEEFKAKDMMMNLTKGNVMLTVLDHIDDKYGNIVALSLSNNRIRHLDYASALVSIAKFVMELDLSHNHISTEKELEKFAGLPVERFFFEGNPVVESFTQRAAYISYIHQSFPRCNMLDGVEVQPLVVGPDLDIHDAMPFRAGYYPNPQIRVLVEQFVTSYFDFYDGPDGQRTRRNLHNAYDADASTFSLTIEHLRGSSHARHHNDECFAQYAGVSHNVLKQERFARHRASRSARGAMDIAVALSKLPTSSHMRDTFIVDVFLQSNDLLGFTVQGLFCDGDLTQTPSPSFFSRSFLVSPRENDSVAVISDQLFITVASLDRLEKFKKLYDQSIANGAAVEQVSAVQIAQIGVNGMGFDGAPALPIREEMIKAMCQFSGMIPPFSEKCLADCAWNFDFACQKFNEIKSSVPAEAFAH
Protein: GTP-binding protein RHO2 (EC 3.6.5.2) (P06781)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- RHO GTPase-activating protein RGD1
- Protein kinase C-like 1
- RHO1 GDP-GTP exchange protein 2
- Rho GDP-dissociation inhibitor
- Rho-type GTPase-activating protein 1
- Post-transcriptional regulator MKT1
- Rho-type GTPase-activating protein 2
- Serine/threonine-protein kinase TOR2
- Rho1 guanine nucleotide exchange factor TUS1
- GTPase-activating protein BEM2/IPL2
Sequence:
MSEKAVRRKLVIIGDGACGKTSLLYVFTLGKFPEQYHPTVFENYVTDCRVDGIKVSLTLWDTAGQEEYERLRPFSYSKADIILIGFAVDNFESLINARTKWADEALRYCPDAPIVLVGLKKDLRQEAHFKENATDEMVPIEDAKQVARAIGAKKYMECSALTGEGVDDVFEVATRTSLLMKKEPGANCCIIL
Protein: Syntaxin (Target SNARE coiled-coil containing protein) (A0A9K4)
Organism: Aspergillus oryzae (Yellow koji mold)
Interaction partners:
Sequence:
MSGGYGSYNPYGGQGGYQQASSIEEGNGSYEMNQVGGGYDNQPADPTSLLNKCREINDGIADIRAKREGQLAAAQNALLDSSTGKEDQVSRQTLDYVEDEINNGFRYLRDLLKKIKQTPGSGDSRVQTQVDVTSRNLRREIEQYQRAQSDFQKRLREQVRRRYEIANPDATPEELEQGVDNVLMGQEQTFQLTGSRTRQANDARQAALERSAAIRKIEQDMIELGRLYQEVAELVHQQEPAVEQINQGAEEVAGNVANANTQITHAIDSARRARKWKWYALLIIILIIAIVVGVAVGVTQANK
Protein: Abscisic stress ripening (D2JX42)
Organism: Musa AAB Group
Interaction partners:
Sequence:
MAEEKHHHHLFHHHKEEKPAEEVIYSETAYSGGGDYASGYTETVVAESASDEYEKYKKEEKHHKHKEHLGEMGAVAAGAFALYEKHEAKKDPDHAHKHKIEEEIAAAVAVGSGGYAFHEHHEKKDAKKEAEEASGKKHHHHLF
Protein: Insulin-like growth factor 1 (Insulin-like growth factor I) (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C) (P05019)
Organism: Homo sapiens (Human)
Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P05017}.
Interaction partners:
- Insulin-like growth factor-binding protein 5
- Insulin receptor
- Insulin-like growth factor-binding protein 3
- Insulin-like growth factor 1 receptor
- Insulin
- Insulin-like growth factor-binding protein 4
- Insulin-like growth factor-binding protein 2
- Insulin-like growth factor-binding protein 6
- Insulin-like growth factor-binding protein complex acid labile subunit
- Insulin-like growth factor-binding protein 1
Sequence:
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRREIGSRNAECRGKKGK