wanglab/gogpt-training-data huggingface dataset:
Protein: Voltage-gated monoatomic cation channel TMEM109 (Mitsugumin-23) (Mg23) (Transmembrane protein 109) (Q3UBX0)
Organism: Mus musculus (Mouse)
Function: May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity).
Subcellular location: Nucleus outer membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}.
Interaction partners:
- Anaphase-promoting complex subunit 4
Sequence:
MAGAHSTPLWSRHLLKAVLMVLVALFLVHSASAQSHREFASPGQQKKETSADILTQIGRSLKEMLDTWLGPETMHVISETLLQVMWAISSAISVACFALSGIAAQLLSALGLDGEQLTQGLKLSPSQVQTLLLWGAAALVIYWLLSLLLGLVLALLGRILGGLKLVLFVAGFVALVRSVPDPSTRALMLLALLTLFALLSRLTGSRSSGSHLEAKVRGLERQIEELRGRQRRAAKMPRSMEEE
Protein: Helix-loop-helix protein (Q90X14)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKAISPVRSVRSCYEAVCCLSEQSLAIARSSNNKSPALEEPMNLLYDMNDCYSKLRELVPGIPQGTKLSQVEILQHVIDYIFDLQIVLEEGAKGRDPSSEATLLSLKAAELASGLCSKDERSLCH
Protein: Uncharacterized protein YqgA (Q46831)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- 4,5-DOPA dioxygenase extradiol
- Protein AaeX
Sequence:
MVIGPFINASAVLLGGVLGALLSQRLPERIRVSMTSIFGLASLGIGILLVVKCANLPAMVLATLLGALIGEICLLEKGVNTAVAKAQNLFRHSRKKPAHESFIQNYVAIIVLFCASGTGIFGAMNEGMTGDPSILIAKSFLDFFTAMIFACSLGIAVSVISIPLLIIQLTLAWAAALILPLTTPSMMADFSAVGGLLLLATGLRICGIKMFPVVNMLPALLLAMPLSAAWTAWFA
Protein: E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase UHRF1) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (E7EZF3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins. However, it is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo (By similarity). Required for pregastrula and lens development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00358}. Cytoplasm {ECO:0000269|PubMed:22072796}. Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions (By similarity). {ECO:0000250}.
Interaction partners:
- DNA
- Euchromatic histone-lysine N-methyltransferase 2.
- Ubiquitin carboxyl-terminal hydrolase 7
- DNA
- DNA ligase
- Proliferating cell nuclear antigen
- Histone H3.3
- Histone H3
- Si:dkey-108k21.24.
- Histone H3
Sequence:
MWIQVRTMDGKETHRVDSLSKLTKVDELRVKIAELFNVEPERQRLFYRGKQMEDGHTIFDYNVGLNDIVQLLVRQAVAATVLPKDKEAELSDSDSGCGSAQSESDKGSTHGESDVQSAGASGQTDTADLIDPGFGFYKINEFVDARDLNMGAWFEAQIVKVTKTPAEDGGAEDIVYHVKYEDYPENGVVQLRGKDVRPRARTVYQWHQLEPGMIVMVNYNPDDPKERGYWYDAEIQRKRETRTQREVFGKILLGDAGDSLNDCRIMFVTEIYKIEEPGSAEGPGASSDSPLKKGSNGPECKVCKDDPKKNCRVCNCHVCGIKQDPDKQLLCDECDMAFHTYCLNPPLTTIPDDEDWYCPDCRNDASEVVLAGEKLKESKKKAKMASASSSSQRDWGKGMACVGRTKQCTIVPSNHYGPVPGVPVGTLWKFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDDGNEFTYTGSGGRDLSGNKRTAEQSCDQKLTNMNRALALNCNAAVNDKEGAEAKDWKAGKPVRVVRSSKGRKHSKYSPEDGNRYDGIYKVVKYWPEKGKSGFLVWRYLLKRNDEESAPWTRDGKERIKKLGLTMQYPEGYLEAVAAKEKEKENKNEDDIEETPTKGKRKRKSQSMEEKSSPTKGTPKKMKVEAYKLSKEQKALIKDDELNKKLWDEAMESLSLGPRFVNKVEEVFLCICCQEVVYQPITTECQHNVCRECLQRSFKAKVYTCPACRHDLGKNYQMAVNKPLQAILTQLFPGYSSGRC
Protein: At4g33925 (Zinc finger SWIM domain protein) (Q147J4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA repair protein RAD51 homolog 4
- Negative regulator of systemic acquired resistance SNI1
- Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A
- Cell cycle checkpoint protein RAD17
- Transcription factor TGA7
- Probable histone H2AXa
- DNA repair protein RAD51 homolog 1
Sequence:
MNVTLLVADAVWSNIESTGSVTEEQLSILQLLFGKNLEKATRIIDKRGVKKISGLPSGRSIFQVVGESQKREEYLCFPGDYCGCYSFFYDVVSRGEHQCCKHQLAARLASSLGTYNEIEVSDDHLALMLSKI
Protein: GATA-binding protein 6 (Gata6 protein) (Transcription factor GATA-6) (Q6NW63)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- NK2 homeobox 5.
- LIM and cysteine-rich domains 1
- Heart- and neural crest derivatives-expressed protein 2
- Forkhead box protein A2
- SRY-box containing gene 17
- T-box transcription factor TBX5-A
- T-box transcription factor TBX20
- Forkhead box A3.
- Hematopoietically-expressed homeobox protein hhex
- T-box transcription factor T-A
Sequence:
MDLGDNSWSMVKREVSSSSSPGSPAEQSYLNTDRRDRLRSPAPTHLDPVGSRRAEGRPLHSYVHFGHPNNALPSSDDVTLFTDLDQGNKLIISGGHPRETHKGGLIVDPTDMYQTLAIAAAQSQAGYNDTPSAGYMHSNPTSPVYVPTSRVGTMIPNLSYLPPGVSTQPSHAVSSHSVWSQPAPESPSYSTGSPHTSNRFHYSPSPPMNNGTSRDTSYTTPLNVNSRDQYLSRPISGSYPSPYPPYVTPQLSQLPAAWPAGPFENSMLHSLQSRSAPLAIRGPNGDLLEEMVESRECVNCGSMSTPLWRRDGTGHFLCNACGLYSKMNGLSRPLIKPQKRMSSSRRIGLSCANCQTSTTTLWRRNAEGEPVCNACGLYTKLHGVPRPLAMKKEGIQTRKRKPKSLSKVKGSSGSSSVPMTPTSSSSSNSEECTKNSPSSTQVPVTSVNSSTLVGQVDVPGTTGSMVKFPGQESLYTNVGLTSSADVASSVRGDSWCPMALA
Protein: Protein Vpu (U ORF protein) (Viral protein U) (P69699)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)
Function: Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation. Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum. Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane. Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation. The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis. Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers. It is thus unsure that this activity plays a role in vivo.
Subcellular location: Host membrane {ECO:0000255|HAMAP-Rule:MF_04082}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04082}.
Interaction partners:
Sequence:
MQPIQIAIVALVVAIIIAIVVWSIVIIEYRKILRQRKIDRLIDRLIERAEDSGNESEGEISALVEMGVEMGHHAPWDVDDL
Protein: Zinc finger protein 480 (F8WEZ9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLCDEKAQKRRKRKAKESGMALPQGHLTFRDVAIEFSQAEWKCLDPAQRALYKDVMLENYRNLVSLGSSYALGSNAEDKPIKKQLGVSFHLHLSELELFPDERVINGCNQVENFINHSSSVSCLQEMSSSVKTPIFNRNDFDDSSFLPQEQKVHLREKPYECNEHSKVFRVSSSLTKHQVIHTVEKPYKCNSCGKVFSRNSHLAEHCRIHTGEKPYKCNVCGKVFSYNSNFARHQRIHTREKPYECNECGKVFSNNSYLARHQRIHAEEKPYKCNECGKGFSHKSSLANHWRIYTGEKPYKCDECGKAFYRIALLVRHQKIHTGEKPYKCNECGKVFIQNSHLAQHWRIHTGEKPYKCNECGKVFNQLSNLARHRRIHTGEKPYKCNECGKAFSEYSGLSAHLVIHTGEKPYKCSECGKAFRHKLSLTNHQRIHTGERPYKCNECGKVFNRIAHLARHRKIHTGEKPYKCNECGKAFSRISYLAQHWTIHMG
Protein: Protocadherin-betaV (Q925L0)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MKIGREHRKRQVLLIFLLLGVVGAGSEPRRYFVMEETPSGTVLADLVQDLGLGVAELAARGAQVVSEEKESRLQLDLQTGKLILNEKLDREELCGSTEPCVTHFQVLLKKPLEIFQAELRVGDINDHSPEFPEREMAVKIIENSPVGTAFLLKTAHDLDVGNNSVQNYKIGTNSHFHVSIRNRGDGRKYPELVLDKELDREVQAAFRLTLTALDAGSPPRTGTSQIRIVVLDVNENAPEFAQAFYRVQIPENSPSGSMVAKVSAKDLDTGTNGEVSYSLFHSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGGGLSGKCSVSIQVVDVNDNYPELIISSLTNPIPENSPETEVALFRIRDRDSGENGRTICSIQDGVPFTLEPSVENFYRLVTDGALDREIRAEYNITISVTDLGIPKLTTQHTITVQVSDINDNAPAFTQVSYTMLVHENNSPALHIGTISATDSDSGSNAHITYSLLPAQEPQLALNSLISINADNGQLFALRALDYEALQAFEFHVSATDRGSPALSSQALVRIVVLDDNDNAPFVLYPMQNASAPCTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLVVKDNGEPPRSASVTLQVLMVDGFSQPYLPLPEVVRDPSHQEGDVLTLYLVIALASVSSLFLLSVLLFVGVRLCRRAREVSLGGCSVPEGHFPGHLVDVSGAGTLSQSYQYEVCLTGDSQSNEFKFLKPVFSGIVDQNYGRQPDDQSFSSVLGM
Protein: Alpha-lactalbumin (Lactose synthase B protein) (Q28049)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
EQLTKCEVFRELKDLKGYGGVSLPEWVCTAFHTSGYDTQAIVQNNDSTEYGLFQINNKIWCKDDQNPHSSNICNISCDKFLDDDLTDDIMCVKKILDKVGINYWLAHKALCSEKLDQWLCEKL
Protein: 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) (EC 1.13.11.46) (Glyoxalase domain-containing protein 1) (Q8K248)
Organism: Mus musculus (Mouse)
Function: May have dioxygenase activity.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q96IR7}.
Interaction partners:
- Homogentisate 1,2-dioxygenase
Sequence:
MTAPARRLCHIAFHVPAGQPLARDLHRVFGFQPLAVREAGGWRQLALRSGDAVFLVNEGTGPQEPLYSLDPHHSVPSATNLCFDVEDVDGAARALAARGCIMPVPPTRVRDAQGTATYTVLSSPAGNLSLTLLQRAGYRGSFLPGFRPLPCTPGPGWVSHVDHLTLACTSGSSPMLMRWFHDCLGFHHLPLSPGEDPEMGLKVAAGSGRGGLRLTALQTPPNNTVPTLVLAESLPGLNSKQDQVEQFLTRHGGPGLQHVGLYTPNIIDASEGMAKAGCRLLTPPEAYYQQPGKEEQILAAGHKPGLLERQGILLDGDKDEFLLQVFTKSLFAEDTFFLELIQRQGATGFGQNNIRALWQSVQEEAARAQGA
Protein: Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (FSH-B) (FSH-beta) (Follitropin beta chain) (Q9PS36)
Organism: Aquarana catesbeiana (American bullfrog) (Rana catesbeiana)
Function: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01225}. Note=Efficient secretion requires dimerization with CGA. {ECO:0000250|UniProtKB:P01225}.
Interaction partners:
Sequence:
CELSNITIVLEKEECGACVSVNATWCSGYCYTKDANLMYPQKSEKQGVCTYTEVIYETVKIPGCAENVNPFYTYPVAVDCHCGRCDSETTDCTVRALGPTYCSLSQD
Protein: F-box/kelch-repeat protein At5g48990 (Q9FI71)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative F-box protein At1g20800
- F-box/kelch-repeat protein At5g42360
- F-box/LRR-repeat/kelch-repeat protein At1g09650
- Putative F-box protein At1g50870
- Putative F-box/FBD/LRR-repeat protein At5g44960
- Putative F-box only protein 11
- F-box/kelch-repeat protein At5g42350
- SKP1-interacting partner 15
Sequence:
MSSPEKKRKKNQKSSPNPSLPEDLIVSILARVSRSYYTNLSVVSKTFRSILTSPELYKTRTLLGKPETFLYVCLRFPDEANPRWLILYRKPNQTLTKKKKKKEDSSVHLLAPIPILNSPTVEWSSLVAVGSYLYAITADIKDSPCSNVWYLDCRTHTWLDSPRLRLAHINSDFNGRTYFPGSSEKPDSLNCVEVYNTNTQTWNPVPPQKRKLKFGNMEGKIYIPPCQENHRKAVALNPKVLTWEAVGLGTNLDRGSFCMIGNIAYCYDPSGKFRWMNCNTAEGDWSRLEGLEGLPKFARYSTVKLAEYGGKLVVLWDKYVAASGYKEKMIWCAEISLEKRNSEEIWGKVEWFDAVLTVPKSYKFVCAKSATV
Protein: Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (A5PN09)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2). Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
Interaction partners:
- Adrenoceptor beta 2, surface a.
- Ubiquitin carboxyl-terminal hydrolase.
Sequence:
MTDSGDLCPHLDSIGEVTKEELIQKSKGTCQSCGVGGPNLWACLQCDCPYVGCGESYSDHSTIHAQAKKHNLTVNLTTFRVWCYVCEREVFLEPKPVTPVSSAHRCKPHDQDPVSQTTCYPLKAVPIAVADEEGSESEEDELKPRGLTGMKNIGNSCYMNAALQALSNCPPLTQFFQDCSGLVRTDKKPALCKSYQKLISELWHKKRPSYVVPTTLFHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPLFDCSGGISEVEPDLSLDSCNLVDGDRSPSEDEFLSCDSGSGSERGDGERAGGEAELLIQDECVAVRGTGGISEKERLKERRGEERTREMDEDADVDTAAQDGQAERETETATPATAVPAPGNTEPDNEASMHCPSSRPCSPAHSVQELHSRLSSNPPRSSPLRTGPTYTFKKAQMLLSTKKKKQSRFRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSSIHQSAPVKAGVCTDGYAAQGWISYIMDSIRRFVVSCIPSWFWGPMVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLKPFLAKESPSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEAYVLFYRKSSEESVRERQRVVALANLKEPSLLQFYISREWLNKFNTFTEPGPITNHTFLCQHGGIPPTKYHYVDDLVVILPQNVWEYLYNRFGGGPAVNHLYVCAICQVEIETLAKRRKLEIDTFIKLNKEFQAEEAPTVILCISMQWFREWENFVKGKDNEPPGPIDNSKIAVMKGGHIQLKQGADYGQISEETWQYLLSIYGGGPEIAVRQTISPPDTDTHGERKIEAETRAL
Protein: UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (A0A8I6ANT4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSQDGASQFQEVILQELELSVKKELEKILTTATSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSIQPYEKIKARGLPDNISSVLNKLVVVKLNGGLGTSMGCKGPKSLIGVRNENTFLDLTVQQIEHLNKTYNTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPRINKESLLPIAKDVSYSGENTEAWYPPGHGDIYASFYNSGLLDTFIEEGKEYIFVSNIDNLGATVDLYILNHLMNPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKFKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNPKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVGIGNILRELFATTDFVSLYLWCGLKELTVVSVVSWSGE
Protein: DNA damage-binding protein 1 (DDB p127 subunit) (Damage-specific DNA-binding protein 1) (UV-damaged DNA-binding factor) (Q805F9)
Organism: Gallus gallus (Chicken)
Function: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (By similarity). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (Probable). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (By similarity). May play a role in the regulation of the circadian clock (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12773817}. Nucleus {ECO:0000269|PubMed:12773817}.
Interaction partners:
- RING-type domain-containing protein.
- Cullin 4A
- DNA damage-binding protein 2
- Cullin 4B
- Protein cereblon
- DDB1 and CUL4 associated factor 1.
- DET1- and DDB1-associated protein 1
- Denticleless protein homolog
- DNA excision repair protein ERCC-8
- Uncharacterized protein.
Sequence:
MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKTAVMELFRPKGESKDLLFILTAKYNACILEYKQNGDNIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRENKELKAFNIRLEELQVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDSHREMDNMLVLSFVGQTRVLMLNGEEVEETELTGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPNGKNISVASCNSNQVVVAVGRALYYLEIRPQELRQINCTEMEHEVACLDITPLGDTNGMSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLSLETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDASGGTTALRPSASTQALSSSVSTSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFHYSDGKLQSLAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTAEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLSHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANLQIDDGSGMKREATVDDLIKIVEELTRIH
Protein: DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) (P43246)
Organism: Homo sapiens (Human)
Function: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26300262}. Chromosome {ECO:0000269|PubMed:26300262}.
Interaction partners:
- Mismatch repair endonuclease PMS2
- DNA mismatch repair protein Msh6
- DNA mismatch repair protein Msh3
- DNA mismatch repair protein Mlh1
- Exonuclease 1
- Serine-protein kinase ATM
- PMS1 protein homolog 1
- DNA mismatch repair protein Mlh3
- DNA polymerase delta catalytic subunit
- Breast cancer type 1 susceptibility protein
Sequence:
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMSEENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT
Protein: Highly divergent homeobox (Q7Z353)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MNLRSVFTVEQQRILQRYYENGMTNQSKNCFQLILQCAQETKLDFSVVRTWVGNKRRKMSSKNSESGTATTGTSLSAPDITVRNVVNIARPSSQQSSWTSANNDVIVTGIYSPASSSSRQGTNKHTDTQITEAHKIPIQKTATKNDTEFQLHIPVQRQVAHCKNASLLLGEKTIILSRQTSVLNAGNSVFNHAKKNYGNSSVQASEMTVPQKPSVCHRPCKIEPVGIQRSYKPEHTGPALHNLCGQKPTIRDPYCRTQNLEIREVFSLAVSDYPQRILGGNAPQKPSSAEGNCLSIAMETGDAEDEYAREEELASMRAQIPSYSRFYESGSSLRAENQSTTLPGPGRNMPNSQMVNIRDMSDNVLYQNRNYHLTPRTSLHTASSTMYSNTNPLRSNFSPHFASSNQLRLSQNQNNYQISGNLTVPWITGCSRKRALQDRTQFSDRDLATLKKYWDNGMTSLGSVCREKIEAVATELNVDCEIVRTWIGNRRRKYRLMGIEVPPPRGGPADFSEQPESGSLSALTPGEEAGPEVGEDNDRNDEVSICLSEGSSQEEPNEVVPNDARAHKEEDHHAVTTDNVKIEIIDDEESDMISNSEVEQVNSFLDYKNEEVKFIENELEIQKQKYFKLQTFVRSLILAMKADDKEQQQALLSDLPPELEEMDFNHASLEPDDTSFSVSSLSEKNVSESL
Protein: Ribulose bisphosphate carboxylase large chain (RuBisCO large subunit) (EC 4.1.1.39) (P0C510)
Organism: Oryza sativa (Rice)
Function: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site (By similarity).
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MSPQTETKASVGFKAGVKDYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVVGEDNQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPTYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREMTLGFVDLLRDDFIEKDRARGIFFTQDWVSMPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAAANRVALEACVQARNEGRDLAREGNEIIRSACKWSPELAAACEIWKAIKFEFEPVDKLDS
Protein: Intercellular adhesion molecule 3 (B8JHX2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- CD209 antigen
Sequence:
MQKGSFFLGKSSRMSHIGLLGICFLSLVAGALECPLQISPQSVVVRYGDSVSVNCSTSVTHDGMGWESTKGGVPLSKASLITWRVSQLTDWEIEPPFCYINYGQQQQCEVALPVTIYKTPDSVSISTANQAMTEGNQYELQCDIHNVAPAQNLTVNWYKGETLVNQTNFTDNTKSPVNKIIRLPIHPDRADDGAQYRCEAELNLGEEGPQPHPKNTSEPLSITVHFKPTIHKLPSTVSVVRGYSKVVVCKSEGHPKPTISWSDGTNTVNGENFTITESTAENLTCTATNAVGSSSRSVTVVIQENITPIIIGIVCGILLVISVIFIYIYITCYKKNKMGHYNFKKPKASKGLLAQPAQTP
Protein: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase P) (Glucuronosyltransferase P) (GlcAT-P) (UDP-glucuronosyltransferase P) (DmGlcAT-BSII) (Q9VTG7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Uncharacterized protein, isoform C
Sequence:
MKGGNYTSLGTCSGINVSGNVAGTRKMSLGKSIKMYLTIFILTTCIYMALYQYHISREPFAASEVVKHQEKSSSYIASYLWSPISLLMANSSSNTNNNSTTTSTTTTTAPTTPTTTTTTTVGSVGQKLGASSISSIRMVSLAATIPSFKSTLSESRSVSLGGHQKTATVKTSTTITTRTTASGLATTKLSATTRTTAKTSAKLSAATTPTASHMENGYKTRPTFVAASLPPPLYIITPTYRRPEQLAELTRLGYTLKHVVNLLWLVIEDANKTNPLVGHTLDRIGVPYEYMVAPMPEKYKQTKKAKPRGVSNRNRGLEYLREHATEGVLYFADDDNTYDISIFEQMRYISKVAMWPVGLVTKTGVSSPIIQAGKLVGYYDGWIGGRKYPVDMAGFAVSVKFLKERPNAQMPFKPGYEEDGFLRSLAPLDDAEIELLADECRDILTWHTQTKKNAPAQALNRTRYKNTNLEHIDRLLVRP