wanglab/gogpt-training-data huggingface dataset:
Protein: ATP phosphoribosyltransferase (ATP-PRT) (ATP-PRTase) (EC 2.4.2.17) (P40373)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Histidine biosynthesis bifunctional protein his7
- Histidinol dehydrogenase
- Imidazole glycerol phosphate synthase hisHF
- 1-
- Histidinol-phosphate aminotransferase
- Imidazoleglycerol-phosphate dehydratase
- ATP-dependent helicase rhp16
- Ribose-phosphate pyrophosphokinase 5
- Ribose-phosphate pyrophosphokinase 2
- Ribose-phosphate pyrophosphokinase 1
Sequence:
MDLVNHLEDRLLFAVPKKGRLYESCVNVLKGSDIKFRRNPRLDIALVQNLPIALVFLPAADIPRFVGTGRVHLGITGQDQIAEARLRIGDKLKIEELVDLQFGGCKLQVQVPESGDITSVDQLVGRRIVTSFEYLVAEYFDKVEKKAKSEGKVDSGIKTEISFVSGSVEASCALGIADAVVDLVESGETMRASGLKPIETVMSTSAVLVRSSNCSSELEPLLQTIITRIRGYIIAQQYVLVNYNVNREHLPVVLKITPGKRAPTITTLDEPGWVAVSSMVVKKEVAQVMDKLSQNHAHDILVLSIDNSRP
Protein: NADH-ubiquinone oxidoreductase chain 6 (EC 7.1.1.2) (Q8HCQ7)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Mitochondrion membrane {ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU004430}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 1
- NADH dehydrogenase subunit 2
- NADH-ubiquinone oxidoreductase chain 5
- NADH dehydrogenase iron-sulfur protein 2
- NADH dehydrogenase iron-sulfur protein 3
- NADH dehydrogenase iron-sulfur protein 3
- NADH-ubiquinone oxidoreductase chain 4L
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MILSVLSSFALVSGLMVVRAKNPVHSVLFFILIFCDTAGLLILLGLDFFAMIFLVIYIGAIAVLFLFVVMMFNIQIAEIHEEVLRYLPVSGIIGLIFWWEMFFILDNETIPLLPTHRNTTSLRYTVYAGKVRNWTNLDTLGNLLYTYYFVWFLVSTLILLVAMIGAIVLTMHRTTKVQRQDVFRRNALDFRRTIMRRTTDQISIY
Protein: Transmembrane protein (Q382U4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSAAGIARHGGLRCSRALVQPSAPMAVLVRGCCCLYALRFFAYSPYDSIRKPPKGKGGSRASCNPIKVAGMSVTNSNCGFPDRACGESPTPWKFPETLKSGRYKDERQRRRRYEGPKVRDSAGPDRRFYRRLKDFREVQDDDPYAGVFNERDSVKKQRVKEWQRQFEEENADVELPYERTNVLARLAPNWFVRYFVNMRDRGGADSLVHVVILAVGLFMTLWIIGRLFYTPPSQARPISELR
Protein: Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) (Q15678)
Organism: Homo sapiens (Human)
Function: Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
Interaction partners:
- Transcriptional coactivator YAP1
- Protein KIBRA
- Catenin beta-1
- Angiomotin
- Serine/threonine-protein kinase LATS1
- 6-pyruvoyl tetrahydrobiopterin synthase
- Protein WWC3
- Vascular endothelial growth factor receptor 3
Sequence:
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQPEDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTPELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKSLHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPESVPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARVLRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI
Protein: Uncharacterized protein (F4JJW8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MENDCTVNIVSLEKDRDVSEASAESQSESTLSNSLDSGVTAETSRSDADSKLDECTAWTNEKHNSYLDYLESSFVRQLYSLLGGGTQRLSRTRDVQSNSHKSADQFTVLQNGCWQKVNFGKKQSCLETSSEFRFHRNSLRNKPENSNGNYTMGTTVQGDVLCHDETKHSEASGQNFREEEEEEEKGEVSKKREREANNDDSSLKEDQVVPVRMVKPRTDPMGYGNRIGVCFR
Protein: histidine kinase (EC 2.7.13.3) (Q9A913)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}.
Interaction partners:
- Regulatory protein VirG
- Phosphate regulon transcriptional regulatory protein PhoB
- DNA-binding response regulator
- DNA-binding response regulator
- PetR protein, putative
- Chemotaxis protein CheYI
- DNA-binding response regulator
- Transcriptional regulator KdpE
- DNA-binding response regulator
- DNA-binding response regulator
Sequence:
MILSRRGAPLFVQALELVIVTLVAAQLISIAVIFTLPPPPPEFYRSSEIVRALKTGQPVQPRDGRLLVVKQDGSIRAGNPETPRRADFKAGIGKALGVPANRVELQIDNGPRFFVRRTPVTPPRPDAPPAGANGRPGAREPFAREGGAPGGGDNARSAQARDEPLIFGDFKVGVRQSDGRWLVVEPKPTLRFDSWQQRILLILLLSVIAVTPLAWLFARRLAQPITAFADAAERLGKDPRTPPLNMTGSGEVVAAASAFNMMQERLRRYVEDRTAMVGAIAHDLRTPLTRLKFRIEAAPEDIRPKLAADIDQMEAMISATLGFVRDTNRPAERTKLELSSLLESVMDEAAETGGDATVERSEKTVIEGDPVALKRLVSNLVENALKYGGRARGRVFSEDGMAIIEIDDDGPGVPPAELERVFEPFYRGEPSRNRETGGIGLGLAVVRSLARAHGGDVVLANRLGGGLRATVKLPA
Protein: Beadex, isoform A (Beadex, isoform C) (Beadex/dLMO protein) (GM05069p) (O77284)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMTMDITKTEPGLVGLSSNQQQQQQQQSQQSNAGMNSGGQNNGPNPNGNGNVVNVVNSGGAGGGNNGNGNVQSIAAAANNNNNNNNNGSQLCAGCGKHIQDRYLLRALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGNLMLCKRDYLRLFGNTGYCAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCENKILCEYDYEERLVFASMANHPMLKRHVSSLGQGSPTGAAGAQNTAGGLLGGGPGGGNVNGVGMVNGPRTPGDHNNNNNGPQTPTGGGSPFAAAAAAAAAAAHMKNQLGASS
Protein: 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (LS) (Lumazine synthase) (EC 2.5.1.78) (P61714)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Interaction partners:
- GTP cyclohydrolase-2
- 3,4-dihydroxy-2-butanone 4-phosphate synthase
- Riboflavin synthase
- Riboflavin biosynthesis protein RibD
- Transcription antitermination protein NusB
- Bifunctional riboflavin kinase/FMN adenylyltransferase
- Thiamine-monophosphate kinase
- 5-amino-6-
- 5-amino-6-
- Transcriptional repressor NrdR
Sequence:
MNIIEANVATPDARVAITIARFNNFINDSLLEGAIDALKRIGQVKDENITVVWVPGAYELPLAAGALAKTGKYDAVIALGTVIRGGTAHFEYVAGGASNGLAHVAQDSEIPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVLKAIKA
Protein: Lysyl oxidase homolog 3B (EC 1.4.3.-) (EC 1.4.3.13) (Lysyl oxidase-like protein 3B) (B8A4W9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (By similarity). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (By similarity). Can mediate oxidation of lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues (By similarity). Required for maturation of neural crest derived cartilage elements.
Subcellular location: Secreted, extracellular space {ECO:0000250|UniProtKB:Q9Z175}. Cytoplasm {ECO:0000250|UniProtKB:P58215}. Nucleus {ECO:0000250|UniProtKB:P58215}. Note=It is unclear how loxl3b is both intracellular (cytoplasmic and nuclear) and extracellular: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, the intracellular location is clearly reported and at least another protein of the family (loxl2) also has intracellular and extracellular localization despite the presence of a signal sequence. {ECO:0000250|UniProtKB:P58215}.
Interaction partners:
Sequence:
MELHQWCRHIIVFLLNVWIPSCFAQTTPPARSSPTPTPQTADNPDSLKFRLSGFPRKHNEGRIEVFYKGEWGTICDDDFSLANAHVLCRQLGFVSATGWTHSAKYGKGAGKIWLDNVQCSGSERSVSVCKSRGWGNSDCTHDEDAGVICKDERLPGFVDSNVIEVQVDENRVEEVRLRPVFTTATKRMPVTEGVVEVKNKDGWAQICDIGWTPKNTHVVCGMMGFPHEKKVNKNFYKLYAERQKNFFLVHSVACLGTEVHLAACPLEFNYGNATESCPGGMPAVVSCVPGPLYTQSPTMKKKLKMPPTTRLKGGAKYGEGRVEVLKGSEWGTVCDDRWNLVSASVVCREMGFGSAKEALTGASMGKGLGPIHMNEVQCTGNERSLWSCRYKNITAEDCKHTEDASVRCNVPYMGYEKTVRILGGRTRYEGRVEVLHREADGTLRWGLICGEGWGTQEAMVLCRQLGLGYANHGLQVRLSGGRSPYEGRVEVRVGQRWGSVCSEGWSTKEAMVLCRQLGLGFSMHAITETWYWDSSNVTDMVMSGVKCTGDEMSISQCQHHRTVNCQKAAARFAAGVICSETASDLVLNAPLVQQTTYIEDRPLHMLYCAAEEDCLSKSAASANWPYGHRRLLRFSSQIHNIGRADFRPKAGRHSWVWHACHGHYHSMDIFTHYDLMSANGTKVAEGHKASFCLEDTDCDEGVSKRYKCANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNYEVSESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEAEKKFEKYPGQLNNQIS
Protein: Signal transduction histidine-protein kinase BaeS (EC 2.7.13.3) (P30847)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
- Transcriptional regulatory protein BaeR
- Multidrug resistance protein MdtC
- Multidrug resistance protein MdtB
- Multidrug resistance protein MdtA
- Periplasmic chaperone Spy
- Putative multidrug resistance protein MdtD
- Probable aminoglycoside efflux pump
- Transcriptional regulatory protein CpxR
- Transcriptional regulatory protein CreB
- Transcriptional regulatory protein HprR
Sequence:
MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNNDRFVFQILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLLAALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV
Protein: Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2 (EC 2.7.1.49) (EC 2.7.4.7) (Hydroxymethylpyrimidine kinase 2) (HMP kinase 2) (Hydroxymethylpyrimidine phosphate kinase 2) (HMP-P kinase 2) (HMP-phosphate kinase 2) (HMPP kinase 2) (O94266)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable thiamine biosynthetic bifunctional enzyme
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c
- Thiamine-repressible acid phosphatase pho4
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1
- Probable acid phosphatase SPBC4.06
- Alkaline phosphatase
- Low molecular weight phosphotyrosine protein phosphatase
- Acid phosphatase
- Thiamine-repressible acid phosphatase SPBC21H7.03c
Sequence:
MPYNPLYESLSNQFDPSRIETVLDPMGYTIKRRALPVSLTIAGSDCSGGAGIQADLKTMTSLGVYGMSAITCLVAENAGGVDSVEEMSPAFVESQIDCCIRDIPCHVVKTGMLGSPEIVKAVARSAKKFNFSKLVVDPVMVATSGDSLVTKDIVSVLNEELLPLTYLVTPNIPEAIVLAKNQGLDISNINSVSDMERCAAVIHKLGPKHVLLKGGHMPVNNLGLKSSDDEDLRVVDILYDGNRFYHFSSSYLKKGEVHGTGCTLSSAIASFLAWEHSLTEAVQFGIDYVHGAITHSPPINNCSTNILNHMTRLRIVPFAPGHFIEYILSHPQVVPAWKEYINHKFTNMLAKGTLPLPAFQDYLKQDYLYLVNFARAYSLKGYKENTFPNILEAAQSVIHVIEEKELHVSMCSSYGVSLQDLKSCEESPACTAYSRYILDTGAAQDVAALDFVQAPCLIGYYVIAARLMKEPFRNPQGPYQKWVDNYFCEDYLSAVRRGCRQIEEIVLKLSPERIQELIEIFIRATKFETLFWETPYYEYVTKQNLEDKEFS
Protein: Hedgehog protein (G3V7Y0)
Organism: Rattus norvegicus (Rat)
Subcellular location: [Sonic hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU280812}. Golgi apparatus membrane {ECO:0000256|RuleBase:RU280812}.; SUBCELLULAR LOCATION: [Protein hedgehog N-product]: Cell membrane {ECO:0000256|RuleBase:RU280812}; Lipid-anchor {ECO:0000256|RuleBase:RU280812}.
Interaction partners:
- Patched
- Hedgehog-interacting protein
- Patched 2
- Brother of CDO
- Cell adhesion molecule-related/down-regulated by oncogenes
- Growth arrest-specific 1.
- Protein smoothened
- Hedgehog protein
- Sonic hedgehog protein
- Low-density lipoprotein receptor-related protein 2
Sequence:
MALPASLLPLCCLALLALSVQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSMPERTLGASGPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHIHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELMG
Protein: Low affinity inorganic phosphate transporter 8 (MtPT8) (MtPht1;8) (Arbuscular mycorrhiza-induced phosphate transporter PT8) (AM-induced phosphate transporter PT8) (H(+)/Pi cotransporter PT8) (G7KDA1)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Low-affinity transporter for external inorganic phosphate (Pi) that may be involved in the acquisition of phosphate released by arbuscular mycorrhizal (AM) fungi (e.g. Glomus versiforme and G.intraradices) during AM symbiosis; not required for mycorrhizal arbuscule development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25841038}; Multi-pass membrane protein {ECO:0000255}. Note=Present on the periarbuscular membrane in cells containing arbuscules during arbuscular mycorrhizal (AM) symbiosis with AM fungi. {ECO:0000269|PubMed:25841038}.
Interaction partners:
Sequence:
MATSHGVLRSLDNAKTQSYHYLAIVIAGMGFFTDAYDLFCITAVTKLIGRLYYSDPTNHSPGILPTNVNNAITGVALCGTLAGQLFFGWLGDKLGRKKVYGITLTTMVGFALLSGLSFGSTPKTVVTSLCFFRFWLGFGIGGDYPLSAVIMSEYANQKTRGSFIAAVFAMQGVGILVAGGVAMFVSKLFLLYFPAPDFETDAVLSTQPEGDFVWRIVLMFGAVPAALTYYWRMKMPETARYTALVEGDHKKAVEDMAKVLDRNILSEESNTRIAIRPLESHSYGLFSSEFLNRHGLHLLGTTSTWFLLDIAFYSLQLTQKDIYPTSGLVYKASKMNAIEEVFQLSRAMFAVALIATVPGYWCTVFLIEKIGRFRIQLIGFLVMSVCMWFLGHNYRSFRGEESACKNGSKYSFCNGNPVMFAILFGLTLFFANFGPNSTTFIVPAELFPARLRSTCHGISAAAGKSGAIVGAFGVQSYIGNSHDKSKGTKQAIMALAVVNLLGFFFTFLVPETQGRSLEEISGEEKDFQGNNADEEISGERNGTRNASVDKSPETSMV
Protein: Zinc finger protein 438 (Q5T427)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPKPIMVIPTLASLASPTTLQSQMLGGLGQDVLLNNSLTPKYLGCKQDNSSSPKPSSVFRNGFSGIKKPWHRCHVCNHHFQFKQHLRDHMNTHTNRRPYSCRICRKSYVRPGSLSTHMKLHHGENRLKKLMCCEFCAKVFGHIRVYFGHLKEVHRVVISTEPAPSELQPGDIPKNRDMSVRGMEGSLERENKSNLEEDFLLNQADEVKLQIKCGRCQITAQSFAEIKFHLLDVHGEEIEGRLQEGTFPGSKGTQEELVQHASPDWKRHPERGKPEKVHSSSEESHACPRLKRQLHLHQNGVEMLMENEGPQSGTNKPRETCQGPECPGLHTFLLWSHSGFNCLLCAEMLGRKEDLLHHWKHQHNCEDPSKLWAILNTVSNQGVIELSSEAEK
Protein: Sesquiterpene synthase 9 (SlTPS9) (Terpene synthase 9) (Beta-myrcene synthase TPS9) (EC 4.2.3.15) (Germacrene C synthase TPS9) (EC 4.2.3.60) (Limonene synthase TPS9) (EC 4.2.3.-) (Sesquiterpene synthase 1) (Terpinolene synthase TPS9) (EC 4.2.3.113) (O64961)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Involved in the biosynthesis of germacrene C, one of the most abundant sesquiterpene in the leaf oil of tomato. Produces mainly germacrene C, but also smaller amounts of germacrene A, B and D when used with farnesyl diphosphate (FPP) as substrate; able to use both (2E,6E)-farnesyl diphosphate ((EE)-FPP) and (2Z,6Z)-farnesyl diphosphate ((ZZ)-FPP). No or low activity with geranylgeranyl diphosphate (GGPP). Can act with a low efficiency as a monoterpene synthase with geranyl diphosphate (GPP) as substrate, thus producing beta-myrcene, limonene and terpinolene.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
- Terpene synthase 17
- Uncharacterized protein
- Terpene synthase metal-binding domain-containing protein
- Terpene synthase metal-binding domain-containing protein
- Alpha-farnesene synthase-like
- Uncharacterized protein
- Uncharacterized protein
- SWIM-type domain-containing protein
- Squalene synthase
Sequence:
MAASSADKCRPLANFHPSVWGYHFLSYTHEITNQEKVEVDEYKETIRKMLVETCDNSTQKLVLIDAMQRLGVAYHFDNEIETSIQNIFDASSKQNDNDNNLYVVSLRFRLVRQQGHYMSSDVFKQFTNQDGKFKETLTNDVQGLLSLYEASHLRVRNEEILEEALTFTTTHLESIVSNLSNNNNSLKVEVGEALTQPIRMTLPRMGARKYISIYENNDAHHHLLLKFAKLDFNMLQKFHQRELSDLTRWWKDLDFANKYPYARDRLVECYFWILGVYFEPKYSRARKMMTKVLNLTSIIDDTFDAYATFDELVTFNDAIQRWDANAIDSIQPYMRPAYQALLDIYSEMEQVLSKEGKLDRVYYAKNEMKKLVRAYFKETQWLNDCDHIPKYEEQVENAIVSAGYMMISTTCLVGIEEFISHETFEWLMNESVIVRASALIARAMNDIVGHEDEQERGHVASLIECYMKDYGASKQETYIKFLKEVTNAWKDINKQFFRPTEVPMFVLERVLNLTRVADTLYKEKDTYTNAKGKLKNMINSILIESVKI
Protein: Glycine receptor subunit alpha-2 (Q7TNC8)
Organism: Mus musculus (Mouse)
Function: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in synaptic plasticity. Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability. Plays a role in cellular responses to ethanol.
Subcellular location: Postsynaptic cell membrane {ECO:0000305|PubMed:15329889}; Multi-pass membrane protein {ECO:0000305}. Synapse {ECO:0000269|PubMed:15329889}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cell projection {ECO:0000269|PubMed:15329889}.
Interaction partners:
- Glycine--tRNA ligase
- Glycine receptor subunit beta
Sequence:
MYRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQMKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
Protein: LP07553p (Q95R95)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MIRRGVLSTTNTRKVMTGLAAFGPAIFMVGASYAGCDRVLVVVLFTICMGLMGAYYAGMKLSPLDMSPNYAGTLMAITNGIGAITGVITPYLVGVMTPNASLLEWRLVFWVAFGVLCFTAVIYCIWASGEVQPFNNAPIQPRSVDFEAQERKVGGEKTSGLEQSS
Protein: Cofilin (Actin-depolymerizing factor 1) (P78929)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Note=Septum. Throughout the cytoplasm (but not on the cytoplasmic cables) and major component of the cortical actin cytoskeleton.
Interaction partners:
- Actin
- Alpha-actinin-like protein 1
- Profilin
- Uncharacterized WD repeat-containing protein C9G1.05
- Tropomyosin
- Fimbrin
- Adenylyl cyclase-associated protein
- Twinfilin
- Actin-related protein 2
- Coronin-like protein crn1
Sequence:
MSFSGVKVSPECLEAFQELKLGKSLRYVVFKMNDTKTEIVVEKKSTDKDFDTFLGDLPEKDCRYAIYDFEFNLGEGVRNKIIFISWSPDVAPIKSKMVYSSSKDTLRRAFTGIGTDIQATDFSEVAYETVLEKVTRK
Protein: TTF-type zinc finger protein with HAT dimerization domain-containing protein (F4IE28)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ceramide synthase LOH1
- Ceramide synthase LOH2
- Uncharacterized CRM domain-containing protein At3g25440
- Phosphatidylinositol:ceramide inositolphosphotransferase 2
- Ceramide kinase
Sequence:
MYRFLKRKSPPPPDINLNELPSDPAKRKSILSYHPNQRDEVRREYLIRGPCQPRGHKFKQIAIGKVLRRFNPKWFDLYGDWLEYSVEKEKAFCLYCYLFRDQTGNQGGSDSFLSTGFCSWNKADRLDQHVGLDVNSFHNNAKRKCEDLMRQGQSIKHALHKQTDVVKNDYRIWLNASIDVSRHLLHQGLPFRGHDESEESTNKGNFVELLKYTAGQNEVVKKVVLKNAPKNNQMTSPPIQKDIVHCFSKEVTRSIIEEMDNDVFGLLVDESADASDKEQMAVVFRFVDKYGVVKERFIGVIHVQETSSLSLKSAIDSLFAKYGLSLKKLRGQGYDGASNMKGEFNGLRSLILKESSSAYYVHCFAHQLQLVVMAVAKKHVEVGEFFYMISVLLNVVGASCKRKDKIREIHRQKVEEKISNGEIKTGTGLNQELSLQRPGNTRWGSHYKTLLRLEELFSSIVIVLEYIQDEGTDTTKRQQAYGILKYFHTFDFVFYLELMLLVMGLTDSLSKALQRKDQDILNAISLVKTTKCQLQKVRDDGWDAFMAKVSSFSEKNNTGMLKMEEEFVDSRRPRKKTGITNLHHYKVDCFYTVLDMQLQEFNDRFDEVNSELLICMSSLSPIDSFRQFDKSMLVRLTEFYPDDFSFVERRSLDHQLEIYLDNVKNDERFTDLKCLGDLARVMVETRKHLSHPLVYRLLKVSLILPVATATVERCFSAMNFVKTTLRNRIGDMFLSDCLVCFIEKQALNTVTNESVIKRFQDMSERRVHL
Protein: N-acetylglutamate synthase, mitochondrial (EC 2.3.1.1) [Cleaved into: N-acetylglutamate synthase, mature form (NAGS-M); N-acetylglutamate synthase, conserved domain form (NAGS-C)] (E7FCP8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (cps1) activity.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q8N159}.
Interaction partners:
- Argininosuccinate lyase
- Argininosuccinate synthase
- Ornithine aminotransferase
- Carbamoyl-phosphate synthase 1
- N-acetyl-D-glucosamine kinase
- ornithine carbamoyltransferase
- Glutamate dehydrogenase 1a
- glutamate dehydrogenase [NAD
- Glutamic pyruvate transaminase
- Alanine aminotransferase 2-like
Sequence:
MAKVNSGSSGCRAMVMAGQFWTKPFALSSQRSGPHRRSAAEVNRRMSSSRTAGHGSKTPLWSQQESYNHSSLGERSAWSNRTLIYRDVKAFLREIGGDPREARYWLTHFQRAGSTPAFAVLEVDPSVFDSHEMVQSLAFGLSFLQRMDMKLVVVMGLPAEITEDDHTRSATDSPLARTVMVKHCQALTEALQDNSANVMPFFSSEALLQLQDNPLDGSSSGPSVVVDSALLQWTLDCRVIPLVCPVGRDTTGRSSVLRSIQVTTAISQTLQPLKVIFLNSSGGIRNQNHKVLGLVSLPGDLPALSCAEWLNEVEQKRIGSIAELLNLLPVESSAVLTSANTLLTELFSHKGSGTLFKNGDPIRRYSSLEDIDVDRLLALINKSFEKNLREDYIASLEGRLHSVYLSEGYSAAAIITTEPVNSGTPYLDKFVVSSSKQGQGTGQILWECIRQDFSKLFWRSRTTNRINPWYFKHCDGSFVNGHWIVFWLGLSDIRESYELVEFAKSHPDSFCSLSTTETKPLQQHHGS
Protein: Rab-like protein 2A (Q9UBK7)
Organism: Homo sapiens (Human)
Function: Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.
Interaction partners:
- Centrosomal protein of 19 kDa
- SH3 and multiple ankyrin repeat domains protein 3
- DCC-interacting protein 13-beta
- Dol-P-Man:Man
- Coiled-coil domain-containing protein 34
Sequence:
MAEDKTKPSELDQGKYDADDNVKIICLGDSAVGKSKLMERFLMDGFQPQQLSTYALTLYKHTATVDGKTILVDFWDTAGQERFQSMHASYYHKAHACIMVFDIQRKVTYRNLSTWYTELREFRPEIPCIVVANKIDDINVTQKSFNFAKKFSLPLYFVSAADGTNVVKLFNDAIRLAVSYKQNSQDFMDEIFQELENFSLEQEEEDVPDQEQSSSIETPSEEVASPHS