wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) (Q9NPA8)
Organism: Homo sapiens (Human)
Function: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.
Subcellular location: Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03046, ECO:0000269|PubMed:22307388}. Note=Localization at the nuclear pore complex requires NUP153 and TPR. {ECO:0000269|PubMed:23591820}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 22
- SAGA-associated factor 29
- Centrin-3
- Centrin-2
- Germinal-center associated nuclear protein
- Ataxin-7
- PCI domain-containing protein 2
- Ataxin-7-like protein 3
- Transformation/transcription domain-associated protein
- Transcription initiation factor TFIID subunit 10
Sequence:
MVVSKMNKDAQMRAAINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKEVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL
Protein: Uncharacterized protein (Q57ZT1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MENQAPPPQHGSTRQTPLSRQSPAPVVATEERVSDGLDMFDLQLLKDCANVPNPFGVAFPGAQALPPSPTVVPSAEIFSSVATASSCLSATMSNPQTARCMTRDVARVILRYISDHVEQQPEKLSEEYERQLILQFVEELHRTNMQPHGGMPSGGDGRLTIDKEVVLSLRNGREGPAPGTDIPRPHHPYAGRGCGGAVNISPRATAFSTGNGMQTQAQGQGQVQQPHLWRSTPPTVASAGVNSNGNGSGANNGRPTTSVMEGSSTSQAVNSAVLTATSLNKRLSGTGVLRPQPQHPRNSARDPIDRRQVTTSTKKVLRSASSAFSECSAGDTGEVSSLISRTTAGTNTMMK
Protein: Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Fibroblast growth factor-regulated protein 2) (Tweak-receptor) (TweakR) (CD antigen CD266) (Q9CR75)
Organism: Mus musculus (Mouse)
Function: Receptor for TNFSF12/TWEAK (By similarity). Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 12
- TNF receptor-associated factor 3
- Tumor necrosis factor
- TNF receptor-associated factor 2
- Tumor necrosis factor receptor superfamily member 5
- Tumor necrosis factor receptor superfamily member 3
- TNF receptor-associated factor 5
- Tumor necrosis factor receptor superfamily member 13C
Sequence:
MASAWPRSLPQILVLGFGLVLMRAAAGEQAPGTSPCSSGSSWSADLDKCMDCASCPARPHSDFCLGCAAAPPAHFRLLWPILGGALSLVLVLALVSSFLVWRRCRRREKFTTPIEETGGEGCPGVALIQ
Protein: Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-2) (FcgammaRIV) (CD antigen CD16a) (A0A0B4J1G0)
Organism: Mus musculus (Mouse)
Function: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Binds with intermediate affinity to both IgG2a and IgG2b. Can bind to IgG2a and IgG2b monomers. Does not display binding to IgG1 or IgG3. Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection. On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses. Mediates neutrophil activation by IgG complexes redundantly with FCGR2A. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE). Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions. Mediates enhanced ADCC in response to afucosylated IgGs.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16039578, ECO:0000269|PubMed:17558411, ECO:0000269|PubMed:28389502}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- High affinity immunoglobulin gamma Fc receptor I
- High affinity immunoglobulin epsilon receptor subunit gamma
- Low affinity immunoglobulin gamma Fc region receptor III
- Tyrosine-protein kinase SYK
- T-cell surface glycoprotein CD3 zeta chain
- Tyrosine-protein kinase HCK
- Tyrosine-protein kinase Lyn
- High affinity immunoglobulin epsilon receptor subunit beta
- Paired immunoglobulin-like receptor B
- Paired-Ig-like receptor A2
Sequence:
MWQLLLPTALVLTAFSGIQAGLQKAVVNLDPKWVRVLEEDSVTLRCQGTFSPEDNSIKWFHNESLIPHQDANYVIQSARVKDSGMYRCQTALSTISDPVQLEVHMGWLLLQTTKWLFQEGDPIHLRCHSWQNRPVRKVTYLQNGKGKKYFHENSELLIPKATHNDSGSYFCRGLIGHNNKSSASFRISLGDPGSPSMFPPWHQITFCLLIGLLFAIDTVLYFSVRRGLQSPVADYEEPKIQWSKEPQDK
Protein: Mitochondrial DNA polymerase I protein B, putative (EC 2.7.7.7) (Q385U8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Pab1p-dependent poly
- DNA-directed DNA polymerase
- Proliferating cell nuclear antigen
Sequence:
MRLNSCWIRRVHRGIAQSNLRCVSTFAALVKVQEALKSSKPFADDAKGFAEFFRVPCLPGVGAQESVRRHYDRVLRDLKQQKDSYVMRQQGQDERVNEELPIFLVSYDTGSKNFYLFSVEKDCNAVRSPADGESDVSGLADELMQYTRGMTQAIMIPIVADEEERGALAPHLTRLSGELKRCGIIPVLSVDSLEIIKTLDPQQSPVRIVTKGRGKHASEPLTEEWFRAHWVHLRTLVFKSSEEDPIITLNRLVAPRFTIYVIHLVRAGSRGLNVALYEPLQKKRYGAKGMLSDVLGCLLERQAKQVIFLPTNRTDRPTLLRCRTALTKMGRTCYLVFPSEIGEKYRGVYQSDPARYWSSLCEVKGSLDADFSFEVYATVGNNIRTQQYKRTRENLLEKQASLSSENNMPAVTNSEVEKWLRVLSLDKRVSCEKAQMRKYKKYLVIAFMATEFAAYTRPANPHAPANYVVATSIMDYQQQVVEPWTKYSSRGEFKLPSLEGFDVIVCHDVKHFVLLIWDDPELRRFLKRGGRVWCTMFAEYLLDAQRCQSGSNSLHDVAMKYGILTPQSSVLGLSTPDLPIAFIQHYLVAAVDAISRVFQEQLKKACGNSQLICVAHRMDSLLAMASIEKAGIHIDSKEATLQAQAIRNRLLAIDKSLSLYAPDEIPLDMQRFFDWTSLQHLQAYFFGGSITLGYTDISRDSSTWTAHLIHLCHKYGNLGLMSADVHLQRFASERGLRGAGRLPQRVARFFDADGSSRRRKYRLVVFDIESTGLNTATDAIIEVAAFDPVEGTSFSSLVNPQRPIPPQSTAIHHITDSMVQGAPRLSEVTQAFARYLRLSEGQRDEDEVTILIGHNVFALDEPLLRRAFRSESVDTENLLFCDSLTILKGLKQELQGSKKDSKFDRGVLDILTNSLRLSSLVEGLRVEADGELHRADTDAKMLWFVLVNAFGIGGKDAVKQRDEVLSHAVRTLVLYPGVGCFLPQERRKDCVTVQLPGVCFKAIKEKRTIEQLRKRHLDEATFVVLQRHKLEVAGLLLQKLQLERGSANFLHSGTDGRLSILHSDNKVRQYIDLTATTTSRTTSSYPSCQNIPKDDKSSLRHLFVSRFGEKGRCVEIDYSQLEIVVMAVLCEDERLVSDLNQGVDFHVKRASFFSGISYDEIYNGYKRGEAKFLKLRKVAKTFSFQRLYGAGVPLLHKTTGIPVQDLQECIRREEEEYPGISRFHRLARTVALRANNPGLPTHFIVELPTGLRVCYKTRDVVLNLPPVKNYPIQSFGAELAQMMIGRVFRQFVRKSFYGQKAFMINFVHDSLWLDCHMSVLEECVHETRTIMEEVDTYVAKTFPGVKLKVPLKVSVDCGVDMCAMESVKDDFSALASQQRSKSSELDALIPELSKEVTDSVEITV
Protein: Longitudinals lacking protein, isoforms J/P/Q/S/Z (Q9V5M6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Subcellular location: Nucleus {ECO:0000269|PubMed:8050351}.
Interaction partners:
Sequence:
MDDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPESSGHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMENDAHDNSNSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKTESAKLTSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTYATWQHDRSQDELGLMAQDAQQRDPQDEAGQNEGGESRIRVRNWLMLADKSIIGKSSDEPSDKLTQSKKSLISDAKTTNKTSTPIRPKVSTTTTSTSTAAAAAAAATIAAKQAAAAIASSNINNNNSSLTQTVTQTVTRIGSIGRTTIACITPANNGNKSSSSNCNVDAASAAALAAAGVELDSIDDTMTEVIVKIENPESMPLNDDEDDAVCNEAIEDENTFDYDLKLGSPLSWTYDAVKIENEEFEDSYLMDNDDDDDDLLTTAAATQKHAKQSNEKQMAGSMVAGAGSGGAVKKIVLSAQQQQQLLEQQQHLQHLQLQPTSQSLQIKLPAIPATITTISAPKQMMSGAGTSGSLTPNNNCTLMSNKLGLPVKGQNLDLHWSHSDDNRYRVLVQNKRTRKESLEHSADMIYNADIEKPWVCRNCNRTYKWKNSLKCHLKNECGLPPRYFCSKMCGYATNVHSNLKRHLNTKCRDREKDADDEKKPGSASGNMPVVVGVGNGTAVPVSSSNNNNNGGGSSTSSTYTLVFQNDSA
Protein: GH17344p (Q8MRL9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNVAKRITDISRNSEKSERERQKMDAEIRKMEEAAMKSYAQDVHSRGDMTARSINTVMRATATAAASGGAHSFAGRSRQVDPMRLEGLSDEEEDQRRVAPGKVTSDAAVPEASLWVEGKSDEGHTYYWNVKTNESVWKPPKEGYLSYEEYERINQLAIDQQQISQAEESLKFRANVDEEVARVNREKMKAFRRTDNPKEKKQKEERRQTFKTEEEAATKEIGQWQTVEVKAPEQPIDWQLPKTDYYSAAPVVSASSEPEPPVKKFKEKTIGGLDEEIAATAPATFKRKFIRKGNSRQRAED
Protein: Ascorbate-specific PTS system EIIA component (Ascorbate-specific phosphotransferase enzyme IIA component) (Q7MBY2)
Organism: Vibrio vulnificus (strain YJ016)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Ascorbate-specific PTS system EIIC component
- Putative sugar phosphotransferase component II B
- Metallo-beta-lactamase domain-containing protein
- Ascorbate-specific PTS system EIIC component
- 3-hexulose-6-phosphate synthase
- L-ribulose-5-phosphate 3-epimerase
- Phosphotransferase system mannitol/fructose-specific IIA component
- Phosphocarrier protein HPr
- L-ribulose-5-phosphate 4-epimerase
- PTS system mannitol-specific EIICBA component
Sequence:
MGLKQSLIENNSIKLQAQASNWRDAIKIGTDMLIASGAIEPCYHDAIISSVEELGPYICIAPNLALPHARPENGVNRTAFALVTLETPIYFEGEDEPVDVLITLAGSSSDEHMEGLMEVTQVLDDEESDTGVDLDKLRRCRSLSDVFNVIDDALAMTA
Protein: Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) (Q9H4A4)
Organism: Homo sapiens (Human)
Function: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Calpain-10
- Aspartyl aminopeptidase
- Cytosol aminopeptidase
Sequence:
MASGEHSPGSGAARRPLHSAQAVDVASASNFRAFELLHLHLDLRAEFGPPGPGAGSRGLSGTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQALCVSFPQPCRAAERLQVLLTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGPNKFFFQMCQPIPSYLIALAIGDLVSAEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAIEAVAISPWKTYQLVYFLDKILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGKQKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPKGS
Protein: Histone H3 (P02299)
Organism: Drosophila melanogaster (Fruit fly)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Heterochromatin protein 1
- Histone H2B
- Histone H4
- Histone H2A
- Chromatin assembly factor 1 p55 subunit
- Histone chaperone asf1
- Polycomb group protein Pc
- Chromo domain-containing protein rhino
- Histone-lysine N-methyltransferase Su
- Histone-lysine N-methyltransferase SETD1
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein: Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF) (P49765)
Organism: Homo sapiens (Human)
Function: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Subcellular location: Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Interaction partners:
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 3
- Vascular endothelial growth factor receptor 1
- Neuropilin-1
- Vascular endothelial growth factor D
- Vascular endothelial growth factor C
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L3
- Placenta growth factor
Sequence:
MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA
Protein: G protein-coupled receptor kinase 2 (EC 2.7.11.16) (Q09639)
Organism: Caenorhabditis elegans
Function: Specifically phosphorylates the activated forms of G protein-coupled receptors (By similarity). Required in adult sensory neurons for chemotaxis. Plays a role in the ASH sensory neurons in the chemotaxis response to NaCl where it is likely to modulate the strength of the NaCl avoidance response which occurs at high NaCl concentrations. Required in the HSN motor neurons for normal egg laying by promoting phosphorylation of amine oxidase amx-2 which inhibits amx-2 activity, preventing metabolism of serotonin. Acts in head acetylcholine neurons to positively regulate locomotion. Inactivates dopamine receptor dop-3 which leads to inactivation of guanine nucleotide-binding protein G(o) subunit goa-1 and activation of the unc-77/nca-1 and nca-2 ion channel proteins.
Interaction partners:
- G protein-coupled receptor kinase 1
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit beta-2
- Arf-GAP domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- Guanine nucleotide-binding protein subunit beta-1
- Calmodulin-like protein
- EF-hand domain-containing protein
- Protein kinase C-like 2
Sequence:
MADLEAVLADVSYLMAMEKSRSQPAARASKRIVLPDPSVRSIMQKFLEKSGDMKFDKIFNQKLGFLLLKDYAENVSESPCPQIKFYEAIKEYEKMETPDERLTKAREIYDHHIMVEMLAHAHNYSKESLQHVQYHLLKQNVPPDLFHRYVLEICDQLRGDIFQRFLESDKFTRFCQWKNLELNMQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLSQHGVFTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVRVSDLGLACDYSKKKPHASVGTHGYMAPEVLAKGVAYDSSADWFSLGCMLYKLLKGHSPFRQHKSKDKNEIDKMTLTQDIELPNEGLSKDCRDLLEGLLKRDVPDRLGCRGKGPTEVKEHPFFKDVDWQTVYLRRMTPPLIPPRGEVNAADAFDIGNFDDDEVKGVKLQDGDSDLYKNFNIVISERWQNEIAETIFEVVNQDADKAESKKRSKQKIKVAVEEKDSDVIVHGYIKKLGGPFTSAWQTKYGKLYPSRLELYPESLTAKPELVFMDQIEDVCAEMQTIKGETAIIVKLRDGFKEPKICLTNSDEISLKEWHTSLRTAHKVSQELLQRMGRKAIKIYGVNHDPMLSESERPGSVTRAFLNRASSVDSGV
Protein: Inosine triphosphatase isoform 2 (A0A0S2Z423)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAASLVGKKIVFVTGNAKKLEEVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGSLAA
Protein: Cellular tumor antigen p53 (A0A8I5ZJF2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU003304}. Nucleus {ECO:0000256|RuleBase:RU003304}.
Interaction partners:
Sequence:
MLYVGDPMRHLATAQFNLLSSAMDQMGSRAAPASPYTPEHAASAPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILVIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRAFKQSPPAIPALGTNVKKRRHGDEDMFYMHVRGRENFEILMKVKESLELMELVPQPLVDSYRQQQQQQLLQRPFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQSHDCGQQLLRSSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGAGGVTGPDEWADFGFDLPDCKSRKQPIKEEFTETESH
Protein: Transcription factor MYB105 (MYB-domain transcription factor LOF2) (Myb-related protein 105) (AtMYB105) (Protein LATERAL ORGAN FUSION 2) (Q9SEZ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that involved in boundary specification, meristem initiation and maintenance, and organ patterning. Functions in both lateral organ separation and axillary meristem formation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Signaling peptide TAXIMIN 1
- Protein CUP-SHAPED COTYLEDON 3
Sequence:
MEMVHADVASLSITPCFPSSLSSSSHHHYNQQQHCIMSEDQHHSMDQTTSSDYFSLNIDNAQHLRSYYTSHREEDMNPNLSDYSNCNKKDTTVYRSCGHSSKASVSRGHWRPAEDTKLKELVAVYGPQNWNLIAEKLQGRSGKSCRLRWFNQLDPRINRRAFTEEEEERLMQAHRLYGNKWAMIARLFPGRTDNSVKNHWHVIMARKFREQSSSYRRRKTMVSLKPLINPNPHIFNDFDPTRLALTHLASSDHKQLMLPVPCFPGYDHENESPLMVDMFETQMMVGDYIAWTQEATTFDFLNQTGKSEIFERINEEKKPPFFDFLGLGTV
Protein: Vimentin (P48616)
Organism: Bos taurus (Bovine)
Function: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P08670}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P08670}. Nucleus matrix {ECO:0000250|UniProtKB:P31000}. Cell membrane {ECO:0000250|UniProtKB:P20152}.
Interaction partners:
- Caspase-3
- Cadherin-1
- Twist-related protein 1
- Collagen alpha-1
- Caspase-3
- Snail family transcriptional repressor 1.
- Zinc finger protein SNAI2
- Zinc finger E-box-binding homeobox 1
- Cadherin-2
- CD44 antigen
Sequence:
MSTRSVSSSSYRRMFGGPGTASRPSSTRSYVTTSTRTYSLGSALRPTTSRTLYTSSPGGVYATRSSAVRLRSGVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAESTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHDEEIQELQAQIQEQHVQIDMDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESNEYRRQVQTLTCEVDALKGTNESLERQMREMEENFSVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE
Protein: Apical endosomal glycoprotein (MAM domain-containing protein 4) (Q63191)
Organism: Rattus norvegicus (Rat)
Function: Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 54
Sequence:
MCLPSCLLSIWVLFMAAQSLGKTWVPDHCRSPTEATCNFVCDCGDCSDEAQCGFHGASTTPNTPFTCNFEQDPCGWQDISTSGYRWLRDRAGAGLDSSGPHSDHTRGTDLGWYMAVGTHSGKEPSTRTLRSPVMREAAPTCELRLWYHTDSRDVAELRLDLTHGMETLTLWQSSGPWGPWPGRELAVNTGRIQGDFKVTFSATRNATHRGAVALDDMEFWDCGLPIPQARCPLGHHHCQNKACVEPHQLCDGEDNCGDSSDEDPLICSHHMATDFETGLGPWTQLEGWTRNFSAGSMVSPAWPHRDHSRNSAYGFFLVSVAKPGTTAVLYSPEFQGSVSYNCSFTFYYYLHGSEANQFQLFVQAQGLNTTQPPVLLRSRHGELGTAWVRDRVNIQSAHPFRILLAGETGPGGFVGLDDLIMSNHCILVPGMSTLQSSLSGPVPLALYPQTSIKRTCDAGHLSCDELCVPPEQLCDFQQHCAEGEDEEKCGTTDFESASAGGWEDISIGKLQWQRAEAQESGKPARDTNRNAPGHFLSLRKAWGQLRSEARALTPTLGPSGPHCELHMTYYFHSHPQGFLALAVVENGFRELLWQAPSSSSGGWTLQKILLGARRWPFQLEFVSLVDLDGPGQQGAGVDNVTLRDCNPMVTTESDQEVSCNFERDSCSWHTGHLTDAHWHRVKSHGSQYDHTTGQGFFMFLDPMDPPARGQGALLLTRPQVPVVPKECLSFWYHLHGPQIGTLCLAMRREGEEDTLLWSRSGTHGNRWHQAWVTLHHQLQPSTKYQLLFEGLRDGYHGTMGLDDMAVRPGPCWAAKRCSFEDSDCGFSPGDWGLWTRQNNASGLGPWGPWIDHTTGTAQGHYMVVDTSPNLLPKGHVASLTSEEHPPLSRPACLSFWYHLSFHNPGTLRVFVEESTRRQELSISGHGGFAWRLGSVNVQAEQAWKVVFEAMASGVEHSYMALDDISLQDGPCAQPGSCDFESGLCGWSHLPWPGLGGYSWDWSSGATPSRYPRPSVDHTVGTEAGHFAFFETSVLGPGGQAAWLGSEPLPATAVSCLHFWYYMGFPAHFYKGELRVLLSSTQGQLAVWHRGGHLRDQWLQVQIEVSSSEEFQIVFEATLGGQPALGPIALDDVEYLAGQHCKQPTPSQGRVAAPVSVPVAVGGALLLFLLLLGLGGWHWLQKQHLPCQSTDAAASGFDNILFNADQVTLPESITSNP
Protein: Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1] (P06454)
Organism: Homo sapiens (Human)
Function: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular location: Nucleus.
Interaction partners:
- Kelch-like ECH-associated protein 1
- Histone H1.0
- Parathymosin
- Nuclear protein 1
- Acidic leucine-rich nuclear phosphoprotein 32 family member A
- Heterogeneous nuclear ribonucleoproteins C1/C2
- Peptidyl-prolyl cis-trans isomerase A
- Large ribosomal subunit protein P1
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL23
Sequence:
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAENEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD
Protein: Utp9p (Q5ADY1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- rRNA-processing protein
- SnoRNA-binding rRNA-processing protein
- Nan1p
- Nucleolar protein 56
- Ribosome biosynthesis protein
- Nucleolar protein 58
- Utp5p
- Rrp9p
- U3 small nucleolar RNA-associated protein 10
- SnoRNA-binding rRNA-processing protein
Sequence:
MKYALNGNKVATLIDRNGKDEIRVYNVDERGDSEVVASIILEDIIDFVWASPTTRKKRTPNGGSKESENQNLLVVLLKESVFVVLSEGSEINRFKIDDQIDKLVKYDENIWAATENSILKVSLDGDVKDKIKVPAFNAISISNKIAFGSTSLQIGKFAKGKFVCEDEIKVVGEIKSILQSKYPVVLTEDNNAYLIKKKVQKLSDAHHIQLLHYREKDYIVAISDNLNFYNDGKLENSISSETALEGVLSVEDSLVVFWSGKNELLFKKIDWSDDEIVIPRGELLMNGTKAHIKVAKPKVYKTDATSLMKKLSGISDHAAIVGLCQSVGDSTVIKEVSKEIGLELFPVISDAVSKDTTNTNLALWFKWIYLIHGKHIAKQDIAPVKEAKTQLESGVKLMSHLIAIQGKLQLLKLQNEMREKNVVRDVTTTIDDDSMVYANGEADII
Protein: Transcription factor tau subunit sfc1 (TFIIIC subunit sfc1) (Transcription factor C subunit 1) (O14229)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor tau subunit sfc3
- Transcription factor tau subunit sfc4
- Transcription factor tau subunit sfc6
- Transcription factor tau subunit sfc7
- Transcription factor IIIB 60 kDa subunit
- Putative transcription factor tau subunit sfc9
- Transcription factor TFIIIB component B''
- TATA-box-binding protein
- DNA-directed RNA polymerase III subunit rpc31
- SAGA complex/transcription factor TFIID complex subunit Taf10
Sequence:
MNSLKISDNEYALIEHPGFANNKDAFFQTLGGVQSIQKACQTSFQNPKQALLELNLRPKDKYHHPVQARVQSRNDLLVTIKKMDNSVQNVSRIRQVFLFRDMADFQYSTQNSPFVQKLDSTLRVLDYNAINKFSIDLTPVQRKHVDMPPPPVFSQTSLPMSYNFLQNPLVGRVRLPNGKTTIVNLKGQCRVWIITTNMGVESVPTCRHSKLGEPSKTIQEVIEALKPLFEKRPVWTRRALLNHLDPSYTHYLKFALPYLSYLWTSGPFRDTYTRFGYDPRKDSNAAAYQALFFKLKLNGKHKGTKTHVFDGKTLFPTNRVYQVCDIVDPTIAPLLKDTQLRSECHRDTGWYRSGRYYKVRDLMREKLFALIEGEMPSEVAVNMILNAEEVEESDRYSNFDEQDNTDLNDTVRGLNTSATDDRINDLMRNLMKRSQEHEGFEDLEEIDDDYDDIFGD