wanglab/gogpt-training-data huggingface dataset:
Protein: Vacuole membrane protein 1 (K7EMI0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYL
Protein: Histone-lysine N-methyltransferase family member SUVH2 (Cytosine-HMTase 2) (H3-K27-HMTase 2) (H4-K20-HMTase 2) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Protein SET DOMAIN GROUP 3) (Suppressor of variegation 3-9 homolog protein 2) (Su(var)3-9 homolog protein 2) (O22781)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone methyltransferase family member that plays a central role in gene silencing. Together with MORC6 and SUVH9, regulates the silencing of some transposable elements (TEs). According to PubMed:15775980, it is required for normal methylation of 'Lys-9' and 'Lys-27' of histone H3, 'Lys-20' of H4, and cytosine, but PubMed:19043555 see no significant effect on histone methylation when the gene is mutated. According to PubMed:19043555, the protein does not bind S-adenosyl-L-methionine and lacks methyltransferase activity. Instead, it may function downstream of DRM2 in RNA-directed DNA methylation, binding to methylated DNA and recruiting DNA-directed RNA polymerase V to chromatin.
Subcellular location: Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Interaction partners:
- Protein DEFECTIVE IN MERISTEM SILENCING 3
- Protein RDM1
- Protein CHROMATIN REMODELING 35
- Calmodulin-lysine N-methyltransferase
- DNA-directed RNA polymerase V subunit 1
- Protein SAWADEE HOMEODOMAIN HOMOLOG 1
- DNA
- Protein MICRORCHIDIA 6
- RNA-dependent RNA polymerase 2
- Protein MICRORCHIDIA 2
Sequence:
MSTLLPFPDLNLMPDSQSSTAGTTAGDTVVTGKLEVKSEPIEEWQTPPSSTSDQSANTDLIAEFIRISELFRSAFKPLQVKGLDGVSVYGLDSGAIVAVPEKENRELIEPPPGFKDNRVSTVVVSPKFERPRELARIAILGHEQRKELRQVMKRTRMTYESLRIHLMAESMKNHVLGQGRRRRSDMAAAYIMRDRGLWLNYDKHIVGPVTGVEVGDIFFYRMELCVLGLHGQTQAGIDCLTAERSATGEPIATSIVVSGGYEDDEDTGDVLVYTGHGGQDHQHKQCDNQRLVGGNLGMERSMHYGIEVRVIRGIKYENSISSKVYVYDGLYKIVDWWFAVGKSGFGVFKFRLVRIEGQPMMGSAVMRFAQTLRNKPSMVRPTGYVSFDLSNKKENVPVFLYNDVDGDQEPRHYEYIAKAVFPPGIFGQGGISRTGCECKLSCTDDCLCARKNGGEFAYDDNGHLLKGKHVVFECGEFCTCGPSCKSRVTQKGLRNRLEVFRSKETGWGVRTLDLIEAGAFICEYAGVVVTRLQAEILSMNGDVMVYPGRFTDQWRNWGDLSQVYPDFVRPNYPSLPPLDFSMDVSRMRNVACYISHSKEPNVMVQFVLHDHNHLMFPRVMLFALENISPLAELSLDYGLADEVNGKLAICN
Protein: Toxic protein HokC (Protein Gef) (P0ACG4)
Organism: Escherichia coli (strain K12)
Function: Toxic component of a type I toxin-antitoxin (TA) system. When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration. Its toxic effect is probably neutralized by antisense antitoxin RNA SokC.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:1943700}; Single-pass type II membrane protein.
Interaction partners:
Sequence:
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE
Protein: Jacalin-related lectin 41 (Q9FGC5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Defensin-like protein 99
Sequence:
MALMVNAKGGNGGKEWDDGFDYEGVTKIHVRAGSEGIQFIKFDYVKVGKTIDGPIHGVSGLGMTQTFEINHLQKEYLVSIEGYYDKSTGVIQSIQFKTNVKTSDMMGFNKGTKFSLGIIRNKIIGFHGFSDKNVYSLGAYFIKVLATKSGMQGGQNTGKSYDYGGDYDGIRKVYVTYDGTSIRHMRVDYDKAGQVECYEYGDKTGTQYKITVNYPYECITSVEGSYANTQPYGCIVLRSLTFKTSNGRTLVIGTVTGTKFLLESKGNAIVGFHGRVGSCVDSIGAYYAPFSPSPPPTQKLEGQGGDGGDSWDDGAFLNVKKVYIGQGSNGIVAVKFEYENDASEVVVGDEHGKTTLLGYEVFELDYPNEYITSLEGCHDKVMGAETGVITMLRFKTNKRTSPPFGLEAGVNFVLQKESHKITGFHGKSSTMLHQIGVHVVPITE
Protein: Guanine nucleotide-binding protein subunit gamma (Q15KE4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU004973}; Lipid-anchor {ECO:0000256|RuleBase:RU004973}; Cytoplasmic side {ECO:0000256|RuleBase:RU004973}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-5a
- Guanine nucleotide-binding protein subunit beta-5b
- Gnb2 protein, beta polypeptide 2)/G
- G protein subunit beta 4.
- Guanine nucleotide binding protein
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein
- Gnb1l protein, beta polypeptide 1, like), beta polypeptide 1b isoform X1), beta polypeptide 1b)
- Guanine nucleotide binding protein
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MATNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLTSYCEAHAKEDPLLSPVPASENPFREKKFFCAIL
Protein: SLACS retrotransposable element (Part), putative (Q38D07)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nucleoside diphosphate kinase-like domain-containing protein
Sequence:
MSNNGYCNKEVAKKLGAVEPNIFSKNGNFEKINRGQIDMTTTKNCRYEDFRSAFERARPAQCMSNNGYCNKEVIRKIGAVGKEKCSKNKEKEQISQADKNDTHGFYADFRSAFTRNGRVELGNNNGYCHNEATRNIERGKKPKTSKIDEKRQISNIAAGRKSDHYEDPSSAFSRISIDHCNAQIKIGRKKMVRNLRSSESQKISRFPRHHGEGKKVSPPALNLQWPGQKQVASAVAPQIRKIATPKNNNTSIQRNCRKHLRKEGDWWIVEGGQSHKKAAHTPLKTKPVNKEGNRKKYGRPPREVEGKWLTSLIAATTEAVLRQLGKGKSPTAHTKSNQSRVPLQHSEKTAKGIKHATPQPKKKEHEQRKELPRRPPTKRSHGANKGQGAPVRAPTKTQGKGEEQPHTMRTWAQVAAPRKPKVTSKPPMAQKKAQGEKKGAAANPFHWELQVEQLLKDAEQIRESMYIRFLHVRQSWWSTCFKAHMEFHCPVCGFAHPEETITVTHCRQQHPQEGRLIPYTLTTTGNQVQFAGPSCSLSAVVAILSHMEEEKNFHPIIRRSYQSPSKETTQTLVQALGLELPTAPITAIEALAHHDQMIRQLLEAPATTARQCGHCGVSELMEGPSNPGENLGIISINPNTCESIELTNQILAKTYTTSWTDMEVVCTGERKNMAHRPTPTLITHSKTFGEMVVIDIGTWGNEAVGLKRILHEILLPHGNGTATYKLVGAVIAPTPFHVVAAIPQQTRKRRWDILDGMVRRTVSQSTVDPKTVVMCVYRREEEETYDVLDEEEQDDDLLGIPNPTPRRLMISQAGPQQNSWVDTRGRRAYGSQEEQDERTSTDQVSIFSHDETRELSSPLECPIVGCTASFVGPRRWEKAKSHIYGFHSLEEVREIPRGELICKGIVRCETCATLLPTSDRAKQAHADDCRPYLPRKENIRRKRAAEREATEASAQQGIALRLERQGPYITPRDIEEPTNTTTESWWREKVATKRYLHRKEWPQWLDICRTVLLGYSASSQGERHQRQVMLLDLVRNHLHTRTARREQQQQRGKDNQEEEDRQKEEEKSLAKRVETLCLLSATEGSPAPRSRKGSTGGVQPRNGSNNRGTVPAGGYP
Protein: Paired box protein Pax-6 (A0A1W2PQA8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWP
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (E7F1P1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane {ECO:0000256|RuleBase:RU000311}; Single-pass type I membrane protein {ECO:0000256|RuleBase:RU000311}.
Interaction partners:
- Vascular endothelial growth factor A-A
- Vascular endothelial growth factor Ab
- Growth factor receptor-bound protein 2
- Runt-related transcription factor
- Kit ligand
- Platelet-derived growth factor c
- Vascular endothelial growth factor C
- Platelet-derived growth factor beta polypeptide a
- Platelet-derived growth factor subunit B
- Placenta growth factor
Sequence:
MHLGIKLLLVLLVLHWSSLKDGLTEAHPRCDTDGSTVRCTLEETDLMSSDPIKLDVTEGQVVEIYSACEQNSSNERKCLCYQRTNSSIHLLQCIEKLGNEKYSVICGNKTVTAVRATQRRPSVPVLKAILKAGSTNLAQLVCTSEGYPKPTLRWYGNSDDAEEGMTSSACKTESTLISYYSYLSKNPNQKCCASNALGEECTEVYHYDLNEEDKQKSQNIIYLKSGQSLLLRAAKKDLRNPGIKWHFNNTVIKGITSLQYYDWTEHLFIESVNMAHSGLYLCTSDTKTPRNCSTHVKVFEHDQIDILHLNENNSILAKNKTDFCFQSQVFSYPKARCYWITPNQTQIQCDETSQSNFTSTFKLCNTEPGQYQMKLETQEYSVMRNVSLCISDIPKITIRKNSSFTTCETESPLPVTVSWKTCPSHAKCDPEDWKEIAADQPEFTDSDQFCQKKIGFSRRHLKSEDHLIKCCITNVAGTGCSEKILLQTKSHTYYVICFLLIVILFMIIIALIIFIRVKKPKYQSQIQMIQMIGPNDNDYIYIDFREFKYDLKWEFPRENLELGNELGSGAFGMVVQATAYGISKPGVSVQVAVKMLKEKHQAVEKEALMSELKMLTHIGHHENIVNLLGACTGSGPVYLIFQYCCNGDLLNYLKSNRECFHKYLTDAFNKDRFRGLYHNFQQNRNSSEYVLSDNSQCLNVTPASKEQEKENDALLSSSISSGSPAEEMLECEDEHQEEELHSLTYDDLLSFSFQVAKGMQFLSAKNCIHRDLAARNVLVTHGRQVKIADFGLARDIEHDSNYVVRGNVRLPVKWMAPESIFKGIYTMESDIWAYGILLWEIFSLGVTPYPGVTVNNTFYRMIESGYHLEQPYYAAESVYKVMCRCWALNPVDRPCFSKIVAFMEKELAALEERLYYNVGGYSHDEITYQNAPVMPEDTPIVTDTHGSGAVRTEPPV
Protein: Putative oxidoreductase Rv1856c (EC 1.-.-.-) (P9WGQ1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable fatty acid synthase Fas
- Possible oxidoreductase
Sequence:
MEVLVTGGDTDLGRTMAEGFRNDGHKVTLVGARRGDLEVAAKELDVDAVVCDTTDPTSLTEARGLFPRHLDTIVNVPAPSWDAGDPRAYSVSDTANAWRNALDATVLSVVLTVQSVGDHLRSGGSIVSVVAENPPAGGAESAIKAALSNWIAGQAAVFGTRGITINTVACGRSVQTGYEGLSRTPAPVAAEIARLALFLTTPAARHITGQTLHVSHGALAHFG
Protein: Homeobox protein Meis1 (XMeis1) (P79937)
Organism: Xenopus laevis (African clawed frog)
Function: Induces expression of a number of neural crest marker genes as part of a heterodimer with isoform b of pbx1, to specify neural crest cell fate. Binds to a highly conserved region in the promoter of the neural crest marker gene zic3.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11960001}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11960001}. Note=Relocation from the cytoplasm to the nucleus is dependent on interaction with pbx1 isoform b.
Interaction partners:
Sequence:
MAQRYDDLPHYGGMDGVGLPSSMYGDPHAARSMKSVHHLNHGPPLHPHQYPHSAHTNAMPPSMGSSVNDALKRDKDSIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFSKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLEGKMPIDLVIDDRDGGSKSDSEDLTRSAPLTDQPSWSRDHDDAASIRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSIASPSTGDDDDPDKEKKRNKGRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPIGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM
Protein: Uncharacterized protein (Q3U4A0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSSEEEAAAEAAGDTHLLGFSDEILLHILSHVPSTDLVLSVRRTCRKLAALCLDKSLVHTVLLQKDYQASEEKVKQLVKEIGREIQQLNMAGCYWLSGSTIEHVARCHSLVKVNLSGCHLTSLRLSKVLSALQHLRSLAIDVSPGFDASQLSSECKATLSRVQELKQTLFTPSYGVVPCCASLQKLLLYFVILDRTREGAVLSGQLMVGQSNVPHYQNLRVFYARLAPGYINQEVVRLYLAVLSDRTPENLHAFLISVPGSFAESGATKNLLDSMARNVALDALQLPKSWLNGSTLLQHMKFNNPFYFSFSRCTLSGGHLIQRLINGGKDLRSLASLNLSGCVHCLSADSLLRKAEDDIDSSILETLVESCCNLHHLNLSAAHHHSSDGLGRHLCQLLARLCHLRSLSLPVCSVADSAPRPDRAPAPPAMHAVPRGFGKKVRIGVQTCPNPFVGQSAPQPASVFWSLLKKLPFLEHLELIGSNFSSAMPRNEPAIRNSLPPCSRAQNVGDSEVAAIGQLTFLRHLTLAQLPGMLTGSGLVSIGLQCQHLQSLSLANLGMMGKVVYMPALADMLKHCKRLKDLRLEQPYFNANAQFFQALGQCSSLQRLCLVSRSGTLQPDAVLAFMARCLQVVMCHMFTGESLTTCKSLQQSLLRSFQAERPALNVVIFPLLHEGLTDVIRDVPMLHLDEITLFKSRVAEEPPNLWW
Protein: Heat shock protein, putative (Q38B38)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRGLIKSFSGRSAPTISTVTLRASICHPAGPLAVPSRLQSTSPMEQLIINGAAWESSNYYHRLGFQEAVRDSSRIKEHYHILAKHFHPDNPNAPPNATAAFQNIKEAYDHLMEEVKDEVPKSHPHTGHSYRFTDHERRQQQMRFLGEGIGLFMAMTLVFIFIVSRHNSNRVEGRYLGHFAIIFLTIQVFPRLLAAAILYACHSNYLVSIAERTEQAAVSLIVEQRESHLAIRAEGIDKRVRDRVVMQVTYPHNDEPRRHTEEGSKDNENNNKKETDTRKGNLGTSPRVLTTVTFDSGVTQVIVPATRAGREPAECRVKVVDEARGFVIVDRTFEI
Protein: Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (PHS II) (Prostaglandin H2 synthase 2) (Prostaglandin-endoperoxide synthase 2) (Q8JH43)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Microsome membrane {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004174}.
Interaction partners:
Sequence:
MNKLVCLVLLSSIWIFPGEGYDPCCAQPCQNQGVCLSKGADAYECDCTRTGYYGENCTTPELLTRIKSALKPRPNVVHHILTHYKSIWDIINSISYLRDGIMRYILLSRSHLVESPPTYNADYGYKSWEAYSNLSYYTRTLAPLPQNCPTPDLPNAKQVVEQVLLRKQFIPDPQRSSLMFAFFAQHFSHQFFKSDFKKGPAFTKALGHGVDLGHIYGETLEVQHKLRLFKDGKLKYQVVDGEVYPPLVKDVQVEMHYPPHIPEEQKFAVGHEAFGLVPGLMMYATIWLREHNRVCDIMKQEHPDWDDERIFQTTRLILIGETIKIVIEDYVQHLSGYNFKLKFDPELIFSERFQYQNRIAAEFNTLYHWHPLLPDNFQIQDQIYGYHQFVFNNSIVTTHGIRNMVDSFTKQTAGRVSGGRNLPPAVQGVAVKVLEQTRQMRYQSFNAYRRRFNMKPYSSFEEMTGDKDLAAQLKELYGHVDKVELYPGLLVEKSRPNSVFGETMVEMGAPYSLKGLMGNAICSPEYWKPSTFGGKVGFDIVNSASLKKLVCLNISGPCPMVSFQVPDVKFQSSENVNSSSVHSTVNNINPTVVLNERSSEL
Protein: Linolenate 9R-lipoxygenase (EC 1.13.11.61) (NspLOX) (Q8YK97)
Organism: Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Function: Catalyzes the conversion of alpha-linoleate to (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate in oxylipin biosynthesis. Also converts alpha-linoleate to (9R,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate.
Interaction partners:
Sequence:
MDLNTYLKLLNLLDSESQKIMLELQAMFSAAGLALRGRGTHTDGIIVKGNLTVLHSSDVPSHSLFTPGKKYDVIFRHANIVGGAKDDALINGRGSAIRIGNIGDDLSKPRLLDLVLNTGEVFGLPTARLYHQFFGSDFHQKSDMLASGSLRRYAVEAALRNPDSFTELYYHTQLCYEWVDSKKKSRYARFRLLNPNQSTEGGLLDDSVEIGPRLVLPRKRGDTREKNYLRNEFRQRLTDGNIVEYVLQAQFRSIEDVAVDCSNIWDPNTYPWLDIAAIVLNQDESENDYYQEIAYNPGNTHYDLKLPNSYSVDDFASLGVSGALVHYFGSIVRAERTQYLYGSKDDLPGKPVYFPLPVTEIPSKRFLFLLEKYNFLTDNSYPSDGEHDKIEALVSAMPTTALDLAVGTTDPTDIPDSYFLERRLNGYNPGAIRESSGQEGWTHELTHNLAKYDIKPGLHFPDFVQCRLFVDKQNGVKLHSIKIDDHEITPCQEQWQYAKRTYLQAEFLSQELKLHLARCHFNIEQYVMAIKRRLAPTHPVRAFINPHLEGLIFINSSAVPKIIGSTGFIPIASMLTQGSIVDVMKNELSKLSYMWNPIADLPRDIPGDLFTPAATAYWELLNNYVEQGLLQPFEDELRTEVNAIQVDELFAELKERSLYSGDQPPKYDSSELKSLLMYIIYHSSFLHSWANFKQYDDAGNPNHVSMGDYSQYDQQTQDKIRFSQRSLTWVLSSIRYNSVAVYGSDLLKQLIREKSSILEPGLPLEDLMMSINI
Protein: Olfactomedin-4 (OLM4) (Antiapoptotic protein GW112) (G-CSF-stimulated clone 1 protein) (hGC-1) (hOLfD) (Q6UX06)
Organism: Homo sapiens (Human)
Function: May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
Subcellular location: Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901, PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). {ECO:0000269|PubMed:15059901, ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:20724538}.
Interaction partners:
- Neutrophil collagenase
- Neutrophil gelatinase-associated lipocalin
- Cadherin-17
- Leucine-rich repeat-containing G-protein coupled receptor 5
- Lactotransferrin
- Achaete-scute homolog 2
- Cell adhesion molecule CEACAM8
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- Defensin alpha 4
- Chromogranin-A
Sequence:
MRPGLSFLLALLFFLGQAAGDLGDVGPPIPSPGFSSFPGVDSSSSFSSSSRSGSSSSRSLGSGGSVSQLFSNFTGSVDDRGTCQCSVSLPDTTFPVDRVERLEFTAHVLSQKFEKELSKVREYVQLISVYEKKLLNLTVRIDIMEKDTISYTELDFELIKVEVKEMEKLVIQLKESFGGSSEIVDQLEVEIRNMTLLVEKLETLDKNNVLAIRREIVALKTKLKECEASKDQNTPVVHPPPTPGSCGHGGVVNISKPSVVQLNWRGFSYLYGAWGRDYSPQHPNKGLYWVAPLNTDGRLLEYYRLYNTLDDLLLYINARELRITYGQGSGTAVYNNNMYVNMYNTGNIARVNLTTNTIAVTQTLPNAAYNNRFSYANVAWQDIDFAVDENGLWVIYSTEASTGNMVISKLNDTTLQVLNTWYTKQYKPSASNAFMVCGVLYATRTMNTRTEEIFYYYDTNTGKEGKLDIVMHKMQEKVQSINYNPFDQKLYVYNDGYLLNYDLSVLQKPQ
Protein: Sperm acrosome-associated protein 9 (Q96E40)
Organism: Homo sapiens (Human)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa. Forms both spirals and striations within ciliary microtubules. May stabilize the protofilaments to which they are bound.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q7TPM5}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q7TPM5}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q7TPM5}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q7TPM5}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Nucleus {ECO:0000250|UniProtKB:Q4V8P4}. Note=In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome. {ECO:0000250|UniProtKB:Q7TPM5}.
Interaction partners:
- Cilia- and flagella-associated protein 77
- Cilia- and flagella- associated protein 210
- Cilia- and flagella-associated protein 90
- Cilia- and flagella-associated protein 144
- EF-hand domain-containing protein 1
- Tubulin beta-4B chain
- Piercer of microtubule wall 1 protein
- EF-hand domain-containing family member C2
- Cilia- and flagella-associated protein 276
- Protein Flattop
Sequence:
MNEVKESLRSIEQKYKLFQQQQLTFTAALEHCRENAHDKIRPISSIGQVQSYMEHYCNSSTDRRVLLMFLDICSELNKLCQHFEAVHSGTPVTNNLLEKCKTLVSQSNDLSSLRAKYPHDVVNHLSCDEARNHYGGVVSLIPLILDLMKEWIAHSEKLPRKVLQHVSEPQAHQESTRGAARPAQAIGTQPRATKHKCRQLTKASLKPRGCSKPPWRPPGGKL
Protein: Actin-related protein 4 (Actin-like protein ARP4) (Actin-like protein 4) (P80428)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. ARP4 recognizes H2AS128ph (gamma-H2A) and is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes. Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates. The INO80 complex is involved in DNA repair by associating to gamma-H2A as a response to DNA damage.
Subcellular location: Nucleus {ECO:0000269|PubMed:8573785}.
Interaction partners:
- Histone acetyltransferase ESA1
- Actin
- SWR1-complex protein 4
- Helicase SWR1
- Actin-like protein ARP8
- Chromatin-remodeling ATPase INO80
- Chromatin modification-related protein YNG2
- RuvB-like protein 2
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
- Ino eighty subunit 4
Sequence:
MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRFR
Protein: General alpha-glucoside permease (Maltose permease MAL11) (Maltose transport protein MAL11) (N1PA11)
Organism: Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast)
Function: High-affinity uptake of alpha-glucosides such as maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose, melezitose and glucose. Acts with the concomitant transport of protons into the cell (symport system) (By similarity). Provides an alternative and minor mechanism for growth on trehalose carbon source by transporting trehalose into the cytoplasm for conversion to glucose by neutral trehalase NTH1.
Subcellular location: Cell membrane {ECO:0000305|PubMed:10368160, ECO:0000305|PubMed:15128531}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKNIISLVSKKKAASKNEDKNISESSRDIVNQQEVFNTEDFEEGKKDSAFELDHLEFTTNSAQLGDSDEDNENVINEMNATDDANEANSEEKSMTLKQALLKYPKAALWSILVSTTLVMEGYDTALLSALYALPVFQRKFGTLNGEGSYEITSQWQIGLNMCVLCGEMIGLQITTYMVEFMGNRYTMITALGLLTAYIFILYYCKSLAMIAVGQILSAIPWGCFQSLAVTYASEVCPLALRYYMTSYSNICWLFGQIFASGIMKNSQENLGNSDLGYKLPFALQWIWPAPLMIGIFFAPESPWWLVRKDRVAEARKSLSRILSGKGAEKDIQVDLTLKQIELTIEKERLLASKSGSFFNCFKGVNGRRTRLACLTWVAQNSSGAVLLGYSTYFFERAGMATDKAFTFSLIQYCLGLAGTLCSWVISGRVGRWTILTYGLAFQMVCLFIIGGMGFGSGSSASNGAGGLLLALSFFYNAGIGAVVYCIVAEIPSAELRTKTIVLARICYNLMAVINAILTPYMLNVSDWNWGAKTGLYWGGFTAVTLAWVIIDLPETTGRTFSEINELFNQGVPARKFASTVVDPFGKGKTQHDSLADESISQSSSIKQRELNAADKC
Protein: Microbody (Peroxisome) biogenesis protein peroxin 2 (Eurofung) (Q5B5X4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004585}.
Interaction partners:
- Peroxisome assembly protein 12
- RING-type E3 ubiquitin transferase
Sequence:
MSSTNFAAAQQRVLERRRKRETEAQSRLAEQQRTSIVNHPAVQRLPYPLNTVSRSGLSIWDAIKGREGTRPAFRVGQVDAELLDEELLGLLKGQVGDALKYFGPHLRDDWSHEIQFVLRAILFKLSIWDHDASYGAALQSLKYVDSRSKGPVHSTPTMLQKSLYGLLTVGGRYAWDKWESWLISREGGYEEPSPEVRSLSRITNFLSTTHSIAAFFSFLIFLVDGRYRTLIDRLLRMRLTPPSAQASREVSFEYLNRQLVWHAFTEFLLFLLPLVGISRWRRWVSRAWRKAMSAIRSTSVDEDEVSEKQGELAFLPERSCAICYKANNTATTETEVIAAASSGAGGIIGSAQTDITNPYETIPCGCIYCFVCIVQKLEGEEGEGWVCLRCGELVKKCKPWNGDVLEEEPKRQSGSGKNVGFAVGDDVPLEQEQAHEQESSVDAG
Protein: GDP-fucose transporter 1 (Solute carrier family 35 member C1) (Q96A29)
Organism: Homo sapiens (Human)
Function: Antiporter specific for GDP-l-fucose and depending on the concomitant reverse transport of GMP. Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:11326279, ECO:0000305|PubMed:11326280, ECO:0000305|PubMed:27738779}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Alpha-mannosidase 2x
- Rap guanine nucleotide exchange factor 5
- Alpha-mannosidase 2
- GDP-mannose 4,6 dehydratase
- Solute carrier family 35 member C2
- Beta-1,4-galactosyltransferase 1
- CMP-sialic acid transporter
- Mannosyl-oligosaccharide glucosidase
- P-selectin
- Adenosine 3'-phospho 5'-phosphosulfate transporter 2
Sequence:
MNRAPLKRSRILHMALTGASDPSAEAEANGEKPFLLRALQIALVVSLYWVTSISMVFLNKYLLDSPSLRLDTPIFVTFYQCLVTTLLCKGLSALAACCPGAVDFPSLRLDLRVARSVLPLSVVFIGMITFNNLCLKYVGVAFYNVGRSLTTVFNVLLSYLLLKQTTSFYALLTCGIIIGGFWLGVDQEGAEGTLSWLGTVFGVLASLCVSLNAIYTTKVLPAVDGSIWRLTFYNNVNACILFLPLLLLLGELQALRDFAQLGSAHFWGMMTLGGLFGFAIGYVTGLQIKFTSPLTHNVSGTAKACAQTVLAVLYYEETKSFLWWTSNMMVLGGSSAYTWVRGWEMKKTPEEPSPKDSEKSAMGV
Protein: Transcription factor RFX4 (Regulatory factor X 4) (Testis development protein NYD-SP10) (Q33E94)
Organism: Homo sapiens (Human)
Function: Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
Interaction partners:
Sequence:
MHCGLLEEPDMDSTESWIERCLNESENKRYSSHTSLGNVSNDENEEKENNRASKPHSTPATLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGAAWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPVPSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGYTGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSVHSARYGNSSDMYTPLTTRRNSEYEHMQHFPGFAYINGEASTGWAK
Protein: Phospholipid scramblase (C9J9P4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFT