wanglab/gogpt-training-data huggingface dataset:
Protein: Transient receptor potential Ca2+ channel 6A (Transient receptor potential cation channel, subfamily C, member 6, isoform CRA_b) (Q99N78)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Podocin
- Nephrin
- Calcium release-activated calcium modulator 2 protein
- Stromal interaction molecule 1
- Bone morphogenetic protein receptor type-2
- Short transient receptor potential channel 3
- Transient receptor potential cation channel subfamily V member 4
- cGMP-dependent protein kinase 2
- Stromal interaction molecule 2
- Alpha-actinin-4
Sequence:
MSQSPGFVTRRGGSPKAAPGAGARRNESQDYLLMDELGDDGYPQLQQPPYGYYPSFRGNENRLTHRRQTVLREKGRRLANRGPAYMFNDHSTSLSIEEERFLDAAEYGNIPVVRKMLEECLSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAILNGDAETRQPGDLARPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMSELIQGHKKGFQEDAEMNKRNEEKKFGILGSHEDLSKFSLDRNQLAHNKQSSTRSSEDFHLNSFSNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRKLGERLSLESKQEESRR
Protein: Alkylglycerone-phosphate synthase (Alkyl-DHAP synthase) (EC 2.5.1.26) (Q585R0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Peroxisome {ECO:0000256|RuleBase:RU363113}.
Interaction partners:
- Dihydroxyacetone phosphate acyltransferase, putative
- Peroxin-7
- Nonspecific lipid-transfer protein, putative
- propanoyl-CoA C-acyltransferase
- Isopentenyl-diphosphate delta-isomerase, putative
- Glycerol-3-phosphate acyltransferase, putative
- Peroxisome targeting signal 1 receptor
- RING-type E3 ubiquitin transferase
- Peroxisome assembly protein, putative
- Peroxin-13
Sequence:
MDKRMITDAFEEIKWNGWGDTGVCIKYDEARQLPIHTNGKPMKHLLKFMKDDVLKVKGEFKIKPTPGLTKEEAIKRLPPPVVKQPFVDELRQVLSKDQIRLDAYARLTHIFGKNYRDLWRVRRGMIDRPPDAVILPNNHDDCVKIMELAQKHNVVVVPFGGGTNVTGGVEPNPFETRRMVISIDMRRMGRMLHIDTESGTAVFEVGVLGPDIDEQLSRYGFMMGHDPDSYAYSTLGGWIAARGSGAMSNKYGDIENMILAMRVVTPVGVVETPLTSRPCGVDLNAMFVGSEGAFGLVTEAVVKIERIPEVKRYEGWLFPSFEVAFTAFHTCTRKGIHPCTMRLYDEDDTRLSFAASTDSGLVSTFFSKCFKKYIATVKGWNLSKISLVVVGFEGTKAQTNCQRSELVGVFQAFGATCLGTKPGNTWQEKKYDLPYLRDFALAHNFWADVFETSVLYTDAIHCWRAVKKSFAEVMAENGKNAWIGCHTAHQYRFGCCLYFTFIGGQADENDLKIFLQVKKRAMEVMLQHRGNLTHHHGIGYEHVPWMKRYNGEGGLDAIMKFKKALDPKNICNPGKLLPSPPSEKETPKATQARQNREMMFDKMGIPGALQAHL
Protein: Endophilin B, isoform A (RE65748p) (Q8SYD9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Caspase-8
- Ubiquitin carboxyl-terminal hydrolase
Sequence:
MNINLPNFNVKNLVKEAGSTISRVVQLTEEKLGTTERTEYDLHFQNLAERADVTKTWTEKIVRDTESVLIPNPQNRVEDFIFEKIEKSKPKRLSNLEHLALDMIEAGGDFGQDLPYGQALIKVGQAEQKLGQCEHDFIATSGICFTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSKDGISPEAVLEQAERDLRVAQAEFDRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCGDVMEQLQRELANLGGPTPYIPLDVNEASASKSNISSGAAARGPGNNHSANMAATGHKPNQPMHVSTDQMQRARVLCSYDAKDHTELNLSANEVIFVTECSPVNEDYMYGKQGLLKGLVPRAFVEMLDEEHDVTL
Protein: SNF1-related protein kinase regulatory subunit beta-2 (AKIN subunit beta-2) (AKINB2) (AKINbeta2) (Q9SCY5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulatory subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17827350}.
Interaction partners:
- SNF1-related protein kinase catalytic subunit alpha KIN11
- SNF1-related protein kinase catalytic subunit alpha KIN10
- SNF1-related protein kinase regulatory subunit gamma-1
- Amino acid transporter AVT6D
- Sucrose nonfermenting 4-like protein
- At5g06430
- At1g10140
- Transcription factor IND
- CBS domain-containing protein CBSCBSPB3
- Serine/threonine-protein kinase GRIK1
Sequence:
MGNVNAREEANSNNASAVEDEDAEICSREAMSAASDGNHVAPPELMGQSPPHSPRATQSPLMFAPQVPVLPLQRPDEIHIPNPSWMQSPSSLYEEASNEQGIPTMITWCHGGKEIAVEGSWDNWKTRSRLQRSGKDFTIMKVLPSGVYEYRFIVDGQWRHAPELPLARDDAGNTFNILDLQDYVPEDIQSISGFEPPQSPENSYSNLLLGAEDYSKEPPVVPPHLQMTLLNLPAANPDIPSPLPRPQHVILNHLYMQKGKSGPSVVALGSTHRFLAKYVTVVLYKSLQR
Protein: Ubiquitin-like protease 4 (EC 3.4.22.-) (Q09275)
Organism: Caenorhabditis elegans
Function: Protease required for deconjugation of smo-1 conjugates from target proteins which is necessary for cell cycle progression (Probable). Required for respiration and the maintenance of normal mitochondrial homeostasis. In response to mitochondrial stress, required for the removal of smo-1 conjugates from the transcription factor dve-1, which promotes the translocation of dve-1 from the cytosol to the nucleus to initiate the mitochondrial unfolded protein response. Furthermore, removes the smo-1 conjugates from the transcription factor atfs-1 to promote its stability and activate the mitochondrial unfolded protein response. Also plays a role in promoting mitochondrial unfolded protein response-mediated innate immunity following infection with P.aeruginosa.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25475837}. Nucleus {ECO:0000269|PubMed:25187565}. Cytoplasm {ECO:0000269|PubMed:25187565}. Mitochondrion matrix {ECO:0000269|PubMed:25187565}. Note=Localizes around the metaphase plate and the pericentriolar region and in the surroundings of the central spindle (PubMed:25475837). Translocates from cytoplasm to mitochondrion at late developmental stages (PubMed:25187565). {ECO:0000269|PubMed:25187565, ECO:0000269|PubMed:25475837}.
Interaction partners:
- Sentrin-specific protease
- Small ubiquitin-related modifier
- Hydroxymethylglutaryl-CoA synthase
- SUMO-conjugating enzyme UBC9
- E3 SUMO-protein ligase gei-17
- UBX domain-containing protein 3
- Ubiquitin-like protease family profile domain-containing protein
- Homeobox protein dve-1
Sequence:
MEVSTSYCTPAVNFKYGSFQDSDVSMREDDLFRMGSYNSQGYYADGTHLDGSIGEEDETSSGSNDQHMDFEEDDFDMESSMTEDLVDEDEEEEDEEDNDEWTNQKRTDNQNSVAYYAAMEMLRIRFPFQSIAIRISDFCCLQEKDLLNDTMIDFYLNHIVEHVLPDSNGSNVTVLPSIFWHNLSLRQHAFDSEDEKMMSDEQKMDLKFGDLHDFVADFDLQDFDYIVVPVNEWEHWSLAVICHPFTAQARTVIFDSQLTADLNNLQNMATLIESFMKYSYEKRTGNAMPFPLPCILPQRMPQQTNNFDCGIFIAEFARRFLLSPPKDLDNFDFAREYPDFSTATKRTEMQRVVLSLSTNRARWRPLVELLNGYSTAAPHRAL
Protein: Aliphatic amidase regulator (P10932)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Positive controlling element of AmiE, the gene for aliphatic amidase. Acts as a transcriptional antitermination factor. It is thought to allow RNA polymerase read through a rho-independent transcription terminator between the AmiE promoter and gene.
Interaction partners:
- Aliphatic amidase expression-regulating protein
- Aliphatic amidase
- ATP-dependent protease ATP-binding subunit-like protein AmiB
- Putative transporter protein AmiS
Sequence:
MSANSLLGSLRELQVLVLNPPGEVSDALVLQLIRIGCSVRQCWPPPESFDVPVDVVFTSIFQNRHHDEIAALLAAGTPRTTLVALVEYESPAVLSQIIELECHGVITQPLDAHRVLPVLVSARRISEEMAKLKQKTEQLQERIAGQARINQAKALLMQRHGWDEREAHQYLSREAMKRREPILKIAQELLGNEPSA
Protein: Guanine nucleotide-exchange factor SEC12 (Prolactin regulatory element-binding protein) (Q9HCU5)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WTV0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WTV0}. Nucleus {ECO:0000250|UniProtKB:Q9WTV0}. Note=Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:28442536}.
Interaction partners:
- Melanoma inhibitory activity protein 2
- Small COPII coat GTPase SAR1A
- Small COPII coat GTPase SAR1B
- Protein transport protein Sec24B
- Protein SEC13 homolog
- Protein transport protein Sec16A
- Protein transport protein Sec24A
- Protein transport protein Sec23A
- Protein transport protein Sec31A
- Protein transport protein Sec24D
Sequence:
MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLELINGRLSASLLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHQQQGNKAEKAGSKEQGPRQRKGAAPAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQSAFPGFL
Protein: Uracil permease (Q10279)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transport of uracil.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Plasma membrane ATPase 1
- Uncharacterized transporter C18H10.16
- Inactive zinc metalloprotease C354.09c
- Probable metal homeostasis protein bsd1
- SPRY domain-containing protein C285.10c
Sequence:
MESVDNNSFFSRIRNSNAYRKVKDFVILDHRPGMTMAERMLTNKDLYPVPPSKRLWGPWNFISFWLADAVNINTWMISATAIELGLNWWEAWICVWVGYLICGILVATTGRPGAVYHISFPVLSRSSFGTWGSLWPILNRSVLACVWYGVQAWIGGECVVLMIRSIWPSFSHIPNTMAKSGTETYQWVGFFIFWLLSNIAIWFPVHQIRHLFTFKAIVAPPAAIAFLIWALVKAHGAGPVIHEPTKLGQYEHAWVVINGIVTCIDGFATLIVNNPDFARFATTPGAVHWPQIITVPLAFGVTSLIGVLVSSASKAIYGTTLWDPTQLLASFLDHSNAHGVRAGVFFIAFGLCIAQLGVNIAANSVSAGNDLSALLPTVINVRRGGYIASIIALCMCPWNLLSSNNNFTTYLSSYSVFLSSFAGVIIADYYFVRKGLIRVAPLYSSSSSSPYYFWKGINFRAFASYICGMLINIVGMAGSTGQKVPKVANTMFNLNYFLGITVACLSHIIICKIFPVTECGEKMLSEVPEEADDYLLTLASEDSIDKDSTSEIYIDGLPTEKEVEKDDVLSITSKKLSGCFP
Protein: C-type lectin domain-containing protein (Q586T1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSMDTRMVNFGFTRAALLCGILLLLTAVCPLHVTAADDDDGRVIVNVKEYFSMDNFAFSRHERYIVGYDNAEAYCVDNGAVLPADQTEAAHQSLQDAMKSVIFEFEAVSYLGGDAVYSSTRVFEADKRCKPGDAASSRHCVYRWNKGLFAKALPDGHGVAFWRGSYVKYAFAAPMNGYPSFWGSEYPKSGQLYTLSWYHEHEDVTTWYDGREASGTIRWTSQNFETKSQDYVVVCEVHDSISTTTTTTAAPASGEVPEPTVTKDEEVTVTTASLEERSNWHIILIALISVVSLIVLLLFLLRWFCDYNVKKEIIPMTLREVVGEPLFVLEPTPFAPPEGFDAPPLALQYYG
Protein: Calponin-1 (Calponin, smooth muscle) (P26932)
Organism: Gallus gallus (Chicken)
Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Interaction partners:
- Myosin-11
- Actin, aortic smooth muscle
- Calmodulin, striated muscle
- Calmodulin
- WD repeat domain 90.
- Uncharacterized protein.
- Smoothelin.
- Actin, cytoplasmic 1
- Centromere protein T
Sequence:
MSNANFNRGPAYGLSAEVKNKLAQKYDPQTERQLRVWIEGATGRRIGDNFMDGLKDGVILCELINKLQPGSVQKVNDPVQNWHKLENIGNFLRAIKHYGVKPHDIFEANDLFENTNHTQVQSTLIALASQAKTKGNNVGLGVKYAEKQQRRFQPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPSLGMERCDTNIIGLQMGSNKGASQQGMTVYGLPRQVYDPKYCDAPGLLGEDGLNHSFYNSQ
Protein: Menin (Q8SXU2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSTITRSASASPMALNGVIDASLFPLKSTADVINLFRRALTSGIEPDLTLLSIVVGYIELSLTTGEAAAQAAQAAAAAVAAGDISQATTGGNDIIMGNSVPFPVVTHELIAGLYKKFQTILSVVEKPKPHRQATREVIKKVSDVIWNSLIRSSYKDRAHLQNLYSYLSGNKLDCFGVALAVVAGCQLLGYKDVRLAISEDHAWVVFGQKRVETIEVTWHGKGSEDKRGQDIRPGIESGSWLYLGGLAVVCERGMEVAAICAALNISLTSNSDCVEVAELQQQLLWLLYDLGHLKRYPMALGTLGELEEIHRTHPSISCEQLYREAIESARTHYRNHHVYPYTYQGNYYNRLLKYRDAFAAWANAADVIRLYTYQCRDDEEIYKELLDIANELIPYVMKTESSGHSARSILRDSEVFANLLRFYDGICQWEEDSLTPILHIGWAKPLVNNITKFDYDIRSQVVIKLPEDLEAEQAKAELARAEQEAKEAKESKEAAGSEAMEGNNNRMATKEEVSILITSHYKFYLTLQSS
Protein: BAG domain-containing protein Samui (Q9BLJ6)
Organism: Bombyx mori (Silk moth)
Function: May play a role in transmitting a signal which both protects non-diapause eggs from cold injury and terminates diapause in diapause eggs.
Interaction partners:
- Endoplasmic reticulum chaperone BIP
- Uncharacterized protein.
- DH domain-containing protein.
Sequence:
MESPVVLDKPPEYHGDRGFPFEEEEGSGAWSELAARHPDIAARLRQRPATWARKRRPSSNDATDDFGDNFSGFDRFPFDDIPPEFREHFPSHWNRRFSSRDEQPQQQTPASPTQPQQQTTATQTEQTPTHSEHEQQTQIPQYGLRNTVDLGQKSPADPSLVDADDRTHRSMSAPPDTPNQTKMSVHNHQEQTHQPHGETQSNVRHIPIFVEGRDKPVINKSVDHGTHFGEAKPQYVPPPPPPHVDRDQYFADDVNFHPPPNFSRSFGTPFNKTYRQGPQPFVQQKAYPQTAFARGASPQRSQSPKPTDEHFVKVPVHHETPKAEPPSRAQKSPQQHQPPPPKSPQQHQPPPPKSPQQQPPPQREQTPPQPKTQQPSSNDPITQILSIQTDVLNLMTDVENFTGTKKDKRYLFLDEMLTRNLIKLDNIETDGKENIRQARKEAIKCIQKCIAVLEAKADSSNQQRKAQPEQETQVQDECQSHDVDMKENTQNDQTTEIPAQPIVENGEVEMDEATKEKPAEPQTAAAVPPQTDNTEEANVEKQAVESAVAVEKDEKQEVVKVEAQEKSEEVKPEDANASGTVNPAETQPPAADTRPEDNKSTGGDAEKKEDKKSTPKKVTKTVKKRDKSKDKKDAPKDSNKEDKIEANSVLNPEPMPVDEKGDKTDSQVMDVDGAASQ
Protein: Glutathione-independent glyoxalase hsp3102 (EC 4.2.1.130) (Glyoxalase 3 homolog 2) (Heat shock protein 31 homolog 2) (Q09675)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:24758716}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable hydroxyacylglutathione hydrolase glo2
- Lactoylglutathione lyase
- Probable hydroxyacylglutathione hydrolase SPCC13B11.03c
- 2-hydroxyacid dehydrogenase homolog 2
- Putative D-lactate dehydrogenase C713.03, mitochondrial
- Glutathione-independent glyoxalase DJ-1
- Copper amine oxidase-like protein cao2
- Threonine dehydratase, mitochondrial
- Tryptophan synthase
- D-serine dehydratase
Sequence:
MSIAKGKNALLVASSYYGPFYPDGKNTGVHFSELLIPYNVFKKAGFNVQFVSENGSYKFDDHSIEESKLGDFERKVFNDKNDDFWTNLNNMKKASDIVGKDYQLLFVAGGHAAMFDLPKATNLQAVAREVFTNGGVLSAVCHGPVLLANVKNPQSVEGKTVVYHKHVTAFNKAGEEKMGVMDELKKRGMKSLNEIFAEAGATFIDPPNPNVNFTQIDGKIVTGVNPQSAKSTAEAAVSAL
Protein: Globin (Q9U1K3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNSDEVQLIKKTWEIPVATPTDSGAAILTQFFNRFPSNLEKFPFRDVPLEELSGNARFRAHAGRIIRVFDESIQVLGQDGDLEKLDEIWTKIAVSHIPRTVSKESYNQLKGVILDVLTAACSLDESQAATWAKLVDHVYAIIFKAIDDDGNAK
Protein: Expression site-associated gene (ESAG) protein, putative (Q580A9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPKLFLLLYVTLFYHVSQSLGRIIALPTGSDAGSIELSGEPFPSGDVALVVNDTAIANIMPTVVKMVNNMLGKYTIPSREVNGIQLGDIPITGIKIGNISLEIKHPNKLVLNVTDIVADAEDTTFSKSLVITSCRGKVRASVAVSSASLVLGLSVDDDEKLKITVDDMNVRFAKLNLTPKLVNWCMVFDNFIIKFIKQQEGSIMGNLQGEIPRAAMGPLEEKLNDFIATAPLVFPESPKITDGELQVLVTIVAPSPGGGSNSSAKTPLLDVPFPERSFGVVASFTAVNTVLVPLVNKSIVKFTKKFAQEFNTSLISAMYPEAYLLCPDCPFMVSVKAETAVHLEPVGLDSLILHLLGIRLALEMKPPEGDPIPAMRLLCNTTVSLSSLYFDSSGAIPLEMDLLDLAIDVETSNIGAIDQLTLNDILSRELRDKVIPAVNEKISTITIFDNTTEPLLNVTSESITFALNVPRGNSSNETSLTTV
Protein: Transcription factor Zelda (Protein vielfaeltig) (Q9VWC6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000269|PubMed:16525017, ECO:0000269|PubMed:22028675, ECO:0000269|PubMed:30518940, ECO:0000269|PubMed:30982648}. Chromosome {ECO:0000269|PubMed:16525017, ECO:0000269|PubMed:22028675}.
Interaction partners:
- Protein twist
- Protein hunchback
- SoxNeuro, isoform B
- Segmentation protein even-skipped
- Homeotic protein bicoid
- Protein zerknuellt 1
- Protein bottleneck
- Dorsal-ventral patterning protein Sog
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MTSIKTEMPPLHAAEALASSSATDSGGGGAGGGGGGGGGGSGGPGAGGTGGVGSAPATPNATISAAADSSDNQPGTPQPTQQQQSTQQQLQQPQSQQQQQQAMGGGDPQQQQQQQQVTGITHQPYATHHMYSASGGQQQQQQQIYGGLYGGDMQQQQGYASSYINSYEQFYQQQQQQQQGTDYAFGTVGVDYGKSAGVRYHPYLQTPTSGLGGIPTASSAQEEAGSAPSAVSTTTAVAMSPRVVSSSSPTSTSSHLQLGSSSGQTPGSPGGAAGSAGCKLQCKKCGILTTNESELQEHIANVHGESPYGSSGYASSPYIKEEMPTPQPPGVGSATANPGELLDLDSQKMVYHQQLLQQQQQQHDVVAGLPLGALPDPLHSMQSMQQRALHSWEQQPQQTVASVEGLPPYMQQGLGVGLGVGVDKSPYYSPKQSPYHQSTGVGGATLIKQEYGGHGLIKSEYPDSQHYVDKSFDPTAGGAGGAELCASVATSPAEFPSTTTGGPGQEGAAGAAPGGGYRGFEPPSSSSVLPANSLTAKAATWKSNEARRPKTYNCTACNKWFTSSGHLKRHYNTTLHKNAVKSSGQPDPATLPISAHHHPARDPVTKPSRRGNAAAAAAAAAAAASASGQGQQQQPPIPPPPANVPPPEPPRSPPDYGGGGGLGVGAMGGAAMSQYSASPSPTQQQQHHLNHHQQQANGYANGTANGYGYMQQQVQSTTNASPQHASNNNSNNQQQQQQQQQHHQQQMPQHHNSVLNGHPNGLAGPSAPHNNNTTQMPSSQMRGLLNETTTTPPPTTTTRAPQITTTATTTTTAATTVAIKSEQMEDSNHTHTHTHTHPNHSHSQDRSHSSSSSSSMATEEAEEQELRDQEQADDHLHQHQQASQQYLLSARHYHSSTPNTLSSSNTNPSTPSSNSPHTIYRQEQQGTDFSRTTPPPQPLPPMGMLPPMAMDYNMLALDMPMPMPTLMHSNMLQCSSTSTTPLATTITTSMPDTMQPPQQQLVHHYQAVLHPLHQQLGEQHQRQEADHHQQQRELHQLDQQQQQQQALILADSLPHSSSSPTSSSPPPTMPMPLTTITAPQLLPLQPPPPHITSTMPMPPTMHMPIMPPPPQCYQQLQPLDPTMSYHTIIGSGPEAHTGTAGGGYSNQITTSDGQILQLMPTSLFAPYAPLSPYSVAAQRSPQEGDLPPVHTLTTALHAHQQGGQQEAQTPTLTVLSTPYSPTVSSSRATPALEMDMATLMQHHQDYEMEQYQMQHQQLDQMQQHQQQLDHQQQQQILADQTQTMAQQPLAKKRRGGNATPSTTKRRRNSSVGSTSPHSTTLPSGRIKCLECDKEFTKNCYLTQHNKSFHSGEYPFRCQKCGKRFQSEDVYTTHLGRHRTQDKPHKCELCPKQFHHKTDLRRHVEAIHTGLKQHMCDICEKGFCRKDHLRKHLETHNRPRVVGKKSAAAAAAAAAAAAVTATAGLGGAPAAGSIKAAFARSLTVTAVSSEPGAGVAIPSAPATATCAPVSVSASALVQAVNPSLTSGLSLKRHIDDVAVDDDSLLEEDEDEMEMEMEMDMLEEEDEEEEELGDHHMIIKSEYVQEEFQMIEKSIELY
Protein: Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) (Q91VA3)
Organism: Mus musculus (Mouse)
Function: Calcium-regulated non-lysosomal thiol-protease (By similarity). Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex.
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000269|PubMed:16476741}.
Interaction partners:
- Calpastatin
- Calpain small subunit 2
- Calpain small subunit 1
Sequence:
MAALAAGISKQRAAAQGLGSNQNAVKYLGQDFETLRKQCLNSGVLFKDPEFPACPSALGYRDLGPGSAETQGIIWKRPTELCSNPQFIVGGATRTDIRQGGLGDCWLLAAIASLTLNEKLLYRVVPRDQSFQKNYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEEGNEFWSALLEKAYAKLNGSYEALAGGSTIEGFEDFTGGISEFYDLRKPPGNLYYTIQKALRKGSLLGCSIDVSNAAEAEATTRQKLVKGHAYSVTGVEEVDFRGLPEKLIRLRNPWGEVEWTGAWSDSAPEWNYIDPQKKGELDKRAEDGEFWMSFSDFLKQFSRLEICNLSPDSLSSEEIHKWNLVLFNGRWTRGSTAGGCQNYPATYWTNPQFKIHLDEVDEDQEEGTSEPCCTVLLGLMQKNRRRQRRIGQGMLSIGYAVYQIPKELENHTDEHLGRDFFQGRQPSTCSSTYMNLREVSSRVQLPPGQYLVVPSTFEPFKDGDFCLRVFSEKKAQALEIGDAVPGDPHEPHPRDMDGEDEHFWSLSEEFADKDSEISAHQLKRVLNGLLSKRTDMKFDGFNINTCREMISLLDGDGTGSLRPVEFKTLWLKICKYLEIYQEMDHSRAGTIDAHEMRTALKKAGFTLNNQVQQTIATRYACSKLGVDFDGFVACMIRLEILFKLFRLLDKDQNGIVQLSLAEWLCRALV
Protein: Ceramide glucosyltransferase 1 (CGT-1) (EC 2.4.1.80) (O18037)
Organism: Caenorhabditis elegans
Function: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide to produce glucosylceramides (GlcCer). GlcCer are known to contribute to the physical properties and physiological functions of membranes and may regulate signal transduction. Only branched-chain sphingoid bases like 15-methylhexadecasphing-4-enine are used for generating complex sphingolipids in Caenorhabditis elegans. Together with cgt-3, plays a role in the trafficking of proteins such as mig-14 to the cell membrane in intestinal cells.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative glucosylceramidase 4
- Putative glucosylceramidase 2
- Sphingomyelin phosphodiesterase 2
- Putative glucosylceramidase 1
- Acid ceramidase
- Ceramide synthase hyl-2
- Putative sphingolipid delta
- Putative sphingomyelin phosphodiesterase asm-3
- Putative neutral sphingomyelinase
- Ceramide kinase 1
Sequence:
MEAANEVVNLFASQATTPSSLDAVTTLETVSTPTFIFPEVSDSQILQLMPATLYSGMNWLRDHLDGFSLLALSGCIFVSVLYLVHIIAFFYSIYRLHHKVEPDPTLPGVSVIKPIVGTDKNLYQNLESFFTSQYHSFELLFCFHSEEDEAIEVVRSLIKKHPNIEAKILFEGEPVGMNPKVNNMMPAYRAARYPLVLISDSAIFMRPDGILDMATTMMSHEKMASVTQIPYCKDRQGFHAAFEQIFFGTSHARLYLVGNFLGVVCSSGMSSMMKKSALDECGGMEKFGEYLAEDYFFAKALTSRGCKAAISTHPALQNSASVTVLSFFNRIGRWIKLRIAMMPHLMVVEPLQDCVTSGLIMAFGLNYLGGYSVYKTFGLHLFYWIVMDFSLMTSMQNGKFNFTPFLFVFIWLFREFTSPFIFIKAVLAPTIVWRNNKFKLSWGGRIRTSKNSQKVPEAVSLSKGAV
Protein: 1-aminocyclopropane-1-carboxylate oxidase homolog 6 (EC 1.14.-.-) (P93824)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
METKEFDSYSERKAFDETKTGVKGLIDAHITEIPRIFCLPQGSLSDKKPFVSTTDFAIPIIDFEGLHVSREDIVGKIKDAASNWGFFQVINHGVPLNVLQEIQDGVRRFHEEAPEVKKTYFTRDATKRFVYNSNFDLYSSSSCVNWRDSFACYMAPDPPNPEDLPVACRVAMFEYSKHMMRLGDLLFELLSEALGLRSDKLKSMDCMKGLLLLCHYYPPCPQPDLTIGTNNHSDNSFLTILLQDQIGGLQIFHQDCWVDVSPIPGALVINMGDFLQLITNDKVISVEHRVLANRAATPRISVASFFSTSMRPNSTVYGPIKELLSEENPSKYRVIDLKEYTEGYFKKGLDGTSYLSHYKI
Protein: Protein broad-minded (TBC1 domain family member 32) (Q96NH3)
Organism: Homo sapiens (Human)
Function: Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Primary cilium assembly protein FAM149B1
- Cilia- and flagella-associated protein 20
- Sodium channel and clathrin linker 1
Sequence:
MAHFSSEDQAMLQAMLRRLFQSVKEKITGAPSLECAEEILLHLEETDENFHNYEFVKYLRQHIGNTLGSMIEEEMEKCTSDRNQGEECGYDTVVQQVTKRTQESKEYKEMMHYLKNIMIAVVESMINKFEEDETRNQERQKKIQKEKSHSYRTDNCSDSDSSLNQSYKFCQGKLQLILDQLDPGQPKEVRYEALQTLCSAPPSDVLNCENWTTLCEKLTVSLSDPDPVFSDRILKFCAQTFLLSPLHMTKEIYTSLAKYLESYFLSRENHIPTLSAGVDITNPNMTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLTVKHNQSHVVSQKILDPIYFFALVDTKAVWFKKWMHAHYSRTTVLRLLETKYKSLVTTAIQQCVQYFEMCKTRKADETLGHSKHCRNKQKTFYYLGQELQYIYFIHSLCLLGRLLIYKQGRKLFPIKLKNKKGLVSLIDLLVLFTQLIYYSPSCPKMTSAAHSENYSPASMVTEVLWILSDQKECAVECLYNNIVIETLLQPIHNLMKGNEASPNCSETALIHIAGILARIASVEEGLILLLYGANMNSSEESPTGAHIIAQFSKKLLDEDISIFSGSEMLPVVKGAFISVCRHIYSTCEGLQVLITYNLHESIAKAWKKTSLLSERIPTPVEGSDSVSSVSQESQNIMAWEDNLLDDLLHFAATPKGLLLLQRTGAINECVTFIFNRYAKKLQVSRHKKFGYGVLVTRVASTAAGGIALKKSGFINELITELWSNLEYGRDDVRVTHPRTTPVDPIDRSCQKSFLALVNLLSYPAIYELVRNQDLPNKTEYSLREVPTCVIDIIDRLIILNSEAKIRSLFNYEQSHIFGLRDFIIDGLSVERNHVLVRINLVGGPLERILPPRLLEKSDNPYPWPMFSSYPLPNCYLSDITRNAGIKQDNDLDKLLLCLKISDKQTEWIENCQRQFCKMMKAKPDIISGEALIELLEKFVLHLTESPSECYFPSVEYTATDANVKNESLSSVQQLGIKMTVRYGKFLSLLKDGAENDLTWVLKHCERFLKQQQTSIKSSLLCLQGNYAGHDWFVSSLFMIMLGDKEKTFQFLHQFSRLLTSAFLWLPRLHISSYLPNDTVESGIHPVYFCSTHYIEMLLKAELPLVFSAFHMSGFAPSQICLQWITQCFWNYLDWIEICHYIATCVFLGPDYQVYICIAVFKHLQQDILQHTQTQDLQVFLKEEALHGFRVSDYFEYMEILEQNYRTVLLRDMRNIRLQST