wanglab/gogpt-training-data huggingface dataset:
Protein: Cell growth-regulating nucleolar protein (Q9NX58)
Organism: Homo sapiens (Human)
Function: Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA. Preferentially binds to a DNA motif containing 5'-GGTTAT-3'. Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity. In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines. Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:31413131}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24495227}. Cytoplasm {ECO:0000269|PubMed:24990247}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q08288}. Note=Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S (PubMed:24495227). Associated with cytoplasmic ribosomes, but not polysomes, as a component of the 60S subunit (PubMed:24990247). In the retina, predominantly expressed in photoreceptor outer segments (By similarity). In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (By similarity). {ECO:0000250|UniProtKB:Q08288, ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:24990247}.
Interaction partners:
- ATP-dependent RNA helicase DDX18
- MKI67 FHA domain-interacting nucleolar phosphoprotein
- Ribosome biogenesis regulatory protein homolog
- Ribosomal RNA processing protein 1 homolog B
- Small ribosomal subunit protein uS19
- Ribosome production factor 2 homolog
- Large ribosomal subunit protein uL10
- Ribosome biogenesis protein BRX1 homolog
- Large ribosomal subunit protein uL5
- H/ACA ribonucleoprotein complex subunit 2
Sequence:
MVFFTCNACGESVKKIQVEKHVSVCRNCECLSCIDCGKDFWGDDYKNHVKCISEDQKYGGKGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEELLVIFNKKISKNPTFKLLKDKVKLVK
Protein: Poly(rC) binding protein 2 (A0A8I5ZZC0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDTGVIEGGLNVTLTIRLLMHGKEVGSIIGKKGESVKKMREESGARINISEGNCPERIITLAGPTNAIFKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGIPQSIIECVKQICVVMLESPPKGVTIPYRPKPSSSPVIFAGGQLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSETGGMGSS
Protein: Fatty acid synthase (EC 1.1.1.100) (EC 1.3.1.39) (EC 2.3.1.38) (EC 2.3.1.39) (EC 2.3.1.41) (EC 2.3.1.85) (EC 3.1.2.14) (EC 4.2.1.59) (A0A0U1RQF0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGPEVQQVPAGERPLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVLAGHGHLYSRIPGLLSPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG
Protein: Polyprotein (Q8QW27)
Organism: Hepatitis C virus subtype 1b
Subcellular location: Host cell {ECO:0000256|ARBA:ARBA00004340}. Host membrane {ECO:0000256|ARBA:ARBA00004551}. Virion membrane {ECO:0000256|ARBA:ARBA00004182}.
Interaction partners:
Sequence:
APITAYSQQTRGLLGCIVTSLTGRDKNQVEGEVQVVSTATQSFLATCINGVCWTVYHGAGSKTLAGPKGPITQMYTNVDLDLVGWQAPPGARSMTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGVFRAAVCTRGVAKAVDFIPVESMETTMR
Protein: Serine/threonine-protein phosphatase rdgC (EC 3.1.3.16) (Retinal degeneration C protein) (P40421)
Organism: Drosophila melanogaster (Fruit fly)
Function: Phosphatase required to prevent light-induced retinal degeneration.
Interaction partners:
- Opsin Rh1
- Phosrestin-1
- Calmodulin
- Neither inactivation nor afterpotential protein C
- Protein retinal degeneration B
- non-specific serine/threonine protein kinase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Sequence:
MDENAIRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRKNQYQGSAHVSVLDDKDDLVEEFGDIVNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPWRLLRDKLAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGEITLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGDGKVDLNEFLEAFRLSDLHRKEQQDENIRRRSTGRPSVAKTATDPVTLLADKISKNTLVVEHDIDPTDCESKVIDPKKS
Protein: Uncharacterized protein (Q57WW5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- AMP-dependent synthetase/ligase domain-containing protein
- Large ribosomal subunit protein uL4m
Sequence:
MSGAFGCGSYRSVVAGTQNVPRRMTFYPSAYELIQLHKAHREVIRHFYVRDKIFDNKFPGNALANGLFKFVPNRRENYHMRELMESIRRRSIWMHRIKQQREINAKVVENMEVKYGKKAAASMLCFTTPDSNAYFAPHRYQDVANSWPNYWQHPSVNHVVPKPRWRRHRELGGITRVEDPFAVQASDY
Protein: Thioredoxin (Trx) (O51088)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Superoxide dismutase
- CoA-disulfide reductase
- Chaperonin GroEL
- DNA polymerase I
- Elongation factor G 2
- Elongation factor G 1
- Borrelia oxidative stress regulator protein BosR
- Co-chaperonin GroES
- Outer membrane protein
Sequence:
MAISLTEEDFVVKVFDYKNDKEWSFRGDRPAIIDFYANWCGPCKMLSPIFEKLSKKYENSIDFYKVDTDKEQDISSAIGVQSLPTILFIPVDGKPKVSVGFLQEDAFENIIKDFFGF
Protein: Transmembrane protein 161B (Q8C2L6)
Organism: Mus musculus (Mouse)
Function: Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival. Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby maintains normal cardiac rhythm.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q7SY10}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Kelch repeat and BTB domain-containing protein 12
Sequence:
MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPSEEELRILAGKQQKGKSKKDRKYNGHIENKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATIVYLVTEVYYSFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQGPVSKLTFKFFLAVFCSLIGAFLTFPGLRLAQMHLDALNMATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGRESVPLMTEATFDTLRLWLIILLCVLRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHMTLLLKTLGNHSWGIYPEAAFPLPVDNNLPANSAYPELPSPDGKMKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA
Protein: Tyrosine-protein phosphatase non-receptor type eak-6 (EC 3.1.3.48) (Enhancer of akt-1 null 6) (G5EGU2)
Organism: Caenorhabditis elegans
Function: Putative phosphatase which, together with eak-4 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16839187}. Cell membrane {ECO:0000269|PubMed:16839187}; Peripheral membrane protein {ECO:0000269|PubMed:16839187}.
Interaction partners:
- Enhancer of AKt-1 null
- Protein eak-4
- MTOR-associated protein MEAK7
- Insulin-like receptor
Sequence:
MTNIREDENIFMFLCEKWILINKNHIWNRINQRINIIADFDRYQRARTISEGQRTENIHRNIYGAVPYDYNLVNLTSTQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDFMAFYNTMKEVGVPLLAVMKNNCMSSFFKKYHHTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQLRHLEKYLEAHANTVRMIDSTNTEDVDKFIKPRDWIVDFDERDRLIGKLQFRKRLKIEKDQVSEQKLVHLKSQLHLFQDTYKYESYVLQ
Protein: DNA replication licensing factor MCM3 (EC 3.6.4.12) (Q5RIC5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368061}.
Interaction partners:
- DNA helicase
- CDC45 cell division cycle 45 homolog
- Chromatin licensing and DNA replication factor 1
- DNA replication licensing factor MCM4
- DNA helicase
- DNA replication licensing factor MCM7
- Cell division control protein
- Cell division cycle 7 homolog
- DNA replication licensing factor MCM2
- Origin recognition complex subunit 5
Sequence:
MAAEVVDDQEMREAQRDYLDFLDDDQDQGIYQSKVRQMISENKSRLIVNLNDLRRRNEKRAAKLLNNAFEELLAFQRALKDLVASIDATYAKQCEEFFIGLEGSFGSKHVSPRTLTSRLLGSMVCLEGIVTKCSLVRPKVVRSVHYCPATKKTMERKYTDLTSLDAFPSSAIYPTKDEENNPLETEFGLSVYKDHQTITIQEMPEKAPAGQLPRSVDIILDNDLVDAVKPGDRTQVIGTYRCLPGKKGGFTSGTFRTIMIACHVKQMSKEISHYFSADDVAKIKSFCRSRSKNVFDQLARSLAPSIHGHEYIKKAILCMLLGGVEKVLENGSRIRGDINVLLIGDPSVAKSQLLRYVLHTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLGDRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRDPHEQDGTALALGGTIDALATEDPDATQEEEEELQVYEKHNPLLHGSKKNKDRVVSKAFMRKYIHVAKAISPVLTQDAANHIAEEYSRLRNQEQLGSDIARTSPVTARTLETLIRLSTAHAKARMSKAVELVDTEVAVELVQFAYFKKVLEKERKRSRNGQQDAASEDEEEEEDEAQDTPRPPRKRRRGSQGSESYDPYDFNTETDIPQIQSPAPALQADEEPDQNGHTELSEDRFKEFKAALHKVFRSSHAQSVGLIALMESINKSCPSAFNETDFRAALARMQDDNQVMLADDIIFLI
Protein: Proteasome subunit beta type-4 (20S proteasome beta subunit G-1) (Proteasome component H) (Proteasome subunit beta type-7) (Q7DLR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-1-B
- Proteasome subunit beta type-2-A
- Proteasome subunit alpha type-2-B
- Proteasome subunit alpha type-7-B
- Proteasome subunit beta type-3-A
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-5-B
- Proteasome subunit alpha type-6-A
Sequence:
MTTFSVPIDNGDSMKIAEEESQRTLYPYVTGTSIVAIKYKDGVLMASDMGGSYGSTLRYKNIERVKAIGKHSLLGASGEISDFQEILRYLDELTLNDNMWDDGNSLGPKEIHNYLTRVMYNRRNKFNPLWNTLVLGGVKNGKSYLGMVSMIGVSFEDDHVATGFGNHLARPILRDEWHADLSFEDGVKLLEKCMRVLLYRDRSAINKLQIAKITEEGVTVSQPYSLKTYWEFSSFHNPTAGAAGSW
Protein: Protein kinase domain-containing protein (H2KYA4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNNRFRPTARRVASAMTDADRRNYHRSRSMDRNKVDYEYGSNLLNRLTTPDSHGDYSYVNYHDSSNGRSNITLEKDGQPRSILKNKQSADIEPRVESSYEPSNGVRSHEFLDQLLSMRFILQVFERLRRHLSLEKSVSPQRQVASVGPHSRNIDSTSSALDNPKKKRSLLSFNRRKTSEVRMGADGKLVTNGYDSTPSSRDFKRPSSPIDRIKSLFRKNESSGTGHSDYYNSSRNYTSSNPVSTTREPYVAQYRKYPGSTSRDTSSALNRYSYTPGLTDQRRHWYDDPNIY
Protein: Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (Hepatic flavin-containing monooxygenase 4) (FMO 4) (Q8VHG0)
Organism: Mus musculus (Mouse)
Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
Subcellular location: Microsome membrane {ECO:0000250|UniProtKB:Q8K4B7}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8K4B7}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAKKVAVIGAGVSGLSSIKCCLDENLEPTCFERTSDFGGLWKFADTSEDGMTRVYRSLVTNVCKEMSCYSDFPFREDYPNFMSHEKFWDYLREFAEHFGLLRYIRFKTTVLSVTKRPDFSETGQWDVVTETEGKRDRAVFDAVMVCTGQFLSPHLPLESFPGIHKFKGQILHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTGTWVLSRSSPGGYPFNMIQTRWLNFLVRVLPSRFINWTHERKMNKILNHENYGLSIAKGKKPKFIVNDELPTCILCGKVTMKTSVKDFTESSVIFEDGTTEANIDVVIFTTGYEFSFPFFEEPLKSLCTKKIILYKRVFPPNLERATLAIIGLISLNGSILVGTEFQARWATRVFKGLCSIPPSQKLMAEATKTEQLIKRGVIKDTSQDKLDFITYMDELTQCIGAKPSIPLLFIKDPRLAWEVFFGPCTPYQYRLVGPGRWDGARNAILTQWDRTLKPLKTRIVPKSPEPTSLSHYLIAWGAPVLLVSLLLIYKSSHFLELVQGKLPRRFPPYRLLWYMPQNS
Protein: Protein Wnt (Q9PS89)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
Sequence:
GVSGSCEFKTCWKAMPPFRKVGNVLKEKFDGATEVEQSEIGSTKVLVPKNSQFKPHTDEDLVYLDSSPDFCDHDLKNGVLGTSGRQCNKTSKAIDGCELMCCGRGFHTDEVEVVERCSCK
Protein: Serine/threonine-protein kinase CLA4 (EC 2.7.11.1) (P48562)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in budding and cytokinesis.
Interaction partners:
- Bud emergence protein 1
- Cell division control protein 42
- Serine/threonine-protein kinase STE20
- Cell division control protein 24
- Rho-type GTPase-activating protein 1
- Serine/threonine-protein kinase STE11
- GTPase-activating protein BEM3
- GTPase-interacting component 2
- GTPase-interacting component 1
- Guanine nucleotide-binding protein subunit beta
Sequence:
MSLSAAANKISDNDFQNIGPAPRPPSSNSQGRTCYNQTQPITKLMSQLDLTSASHLGTSTSKKKSGWVSYKDDGILSFIWQKRYLMLHDSYVALYKNDKQNDDAILKIPLTSIISVSRTQLKQYCFELVRCSDRNSVSSGSSSSLNVSSDSNSKKSIYIATKTESDLHSWLDAIFAKCPLLSGVSSPTNFTHKVHVGFDPETGSFVGMPTNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEYNGAGNPTNTLDKPQSGETSSSQKSLPNSYNDNKLRNNSVNSKSSSGVSSSMVSQRKTSQPPNTKSPVSLGSGSLPPINTKLPTSQSNIPRHLQNVPNQQYPKMRNGHSPTNGQFPRGPMHPNNSQRSLQQQQQQQQQQKQQHQQYPYHHQGPSPSPSPSPSPLNPYRPHHNMINPYSKQPQSPLSSQSTQNQAIPRYAQNSSPTAAHFQPQRTAPKPPISAPRAPYPSNQNATSNTHVQPVAPKNDQSTPQTMRQAPKRPDADVAQPGGVAKPKKPARPTMSTAEIMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFFNMACDPKDLTSLLEWKE
Protein: CDP-diacylglycerol--serine O-phosphatidyltransferase 1 (EC 2.7.8.8) (Phosphatidylserine synthase 1) (F4HXY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. Is essential for phosphatidylserine (PS) biosynthesis and PE seems to be the most plausible substrate. Plays an important role in microspore maturation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21554450}; Multi-pass membrane protein {ECO:0000269|PubMed:21554450}. Nucleus envelope {ECO:0000269|PubMed:21554450}. Note=Mainly localized in nuclei and ER membranes during pollen development.
Interaction partners:
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Phosphatidylserine decarboxylase proenzyme 2
- Phosphatidylserine decarboxylase proenzyme 3
- Phospholipase D beta 2
- Phospholipase D gamma 2
- Phospholipase D gamma 3
- Phospholipase D zeta 1
- Phospholipase D gamma 1
- Phospholipase D alpha 3
- Phospholipase D alpha 4
Sequence:
MEPNGYRKERRKEQHLGRMNGGGGDVETDLDPWTAWAYKPRTISLLLIGACFLIWASGALDPDSTTSDDLVTSVKRGVWAMIAVFLAYSLLQAPSTVLIRPHPAIWRLVHGMAVIYLVALTFLLFQRRDDARQFMKFLHPDLGIELPEKSYGADCRIYVPDHPTNRFKNLYDTVFDEFFLAHIFGWWGKAILIRNQPLLWVLSIGFELLEVTFRHMLPNFNECWWDSIVLDILICNWFGIWAGMYTVRYFDGKTYEWVGISRQPNIIGKVKRTLGQFTPAHWDKDEWHPLQGPWRFIQVLTLCIIFLTVELNTFFLKFSLWIPPRNPVILYRLILWWLIAIPTTREYNSYLQDRKPVKKVGAFCWLSLGICIVELLICIKFGSGLYPTEMPLWVVTLWGSVGLGLVAFLLSWTWKIQKILAQKRR
Protein: Uncharacterized peptidase C22G7.01c (EC 3.4.-.-) (Q09795)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized bolA-like protein C8C9.11
- Uncharacterized bolA-like protein C4B3.11c
Sequence:
MVVHTGNRLNKLRELMKERGYTLYVVPSEDAHSSEYTCDADARRAFISGFDGSAGCAVIGETSAALFTDGRYFNQASQQLDENWTLMKQGFTGVPTWEEYCTQMTKCNEKVGIDSSLITFPAAKALRESLFLKSGAVLVGDHDNLVDIVWGASRPKEPLEKLIVQEIKYAGLGVDEKLHNLREAMKEQKIEAFVVSMLDEVAWLYNLRGADVPYNPVFFAYSLVTLDEAFLYVDERKVTPEVSKHLDGFVKILPYDRVFSDAKNSNLTRIGISSKTSWCIATSFGETKVMPILSPISQAKGIKNDAELKGMKECHIRDGCALVEYFAWLDEYLNSGNKINEFDAATKLEQFRRKNNLFMGLSFETISSTGPNGAVIHYSPPATGSAIIDPTKIYLCDSGAQYKDGTTDVTRTWHFGEPSEFERQTATLALKGHIALANIVFPKGTTGYMIDVLARQYLWKYGLDYLHGTGHGVGSFLNVHELPVGIGSREVFNSAPLQAGMVTSNEPGFYEDGHFGYRVENCVYITEVNTENRFAGRTYLGLKDLTLAPHCQKLIDPSLLSPEEVKYLNEYHSEVYTTLSPMLSVSAKKWLSKHTSPI
Protein: Ribonuclease VapC21 (RNase VapC21) (EC 3.1.-.-) (Toxin VapC21) (P9WF91)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB21.
Interaction partners:
- Antitoxin VapB21
- Winged helix-turn-helix domain-containing protein
- site-specific DNA-methyltransferase
- Ribonuclease VapC9
- Ribonuclease VapC42
- Putative antitoxin VapB42
- Possible type I restriction/modification system specificity determinant HsdS
Sequence:
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEIQEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Protein: ATP-dependent RNA helicase DBP9 (EC 3.6.4.13) (DEAD box protein 9) (Q06218)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11565753}.
Interaction partners:
- Ribosome biogenesis protein MAK21
- Ribosome biogenesis protein RPF2
- Ribosome biogenesis protein NSA1
- Nucleolar protein 4
- Ribosome biogenesis protein SSF1
- rRNA-processing protein EBP2
- Ribosome biogenesis protein ERB1
- Nucleolar complex protein 2
- rRNA biogenesis protein RRP5
- Pescadillo homolog
Sequence:
MSYEKKSVEGAYIDDSTTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIDNGEENGTLGIILVPTRELAQQVYNVLEKLVLYCSKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKINSISLNELKFLVVDEVDLVLTFGYQDDLNKIGEYLPLKKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDEEINKNQNKLLQYYVKVSEFDKFLLCYVIFKLNLIKGKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLLIATDDTEYIKEEDDEIEEGHNTENQEEKSLEGEPENDKKPSKKKKVQVKKDKEYGVSRGVDFKNVACVLNFDLPTTAKSYVHRVGRTARGGKTGTAISFVVPLKEFGKHKPSMLQTAKKDERILSRIIKQQSKLGLELQPYKFDQKQVEAFRYRMEDGFRAVTQVAIREARVKELKQELLASEKLKRHFEENPKELQSLRHDKELHPARVQQHLKRVPDYLLPESARGNGTKVKFVPFHNAKKRHSHKKGRVSKPKNGKVDPLKNFK
Protein: Eukaryotic translation initiation factor 4 gamma 1 (E7EX73)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPQAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Protein: Heterogeneous nuclear ribonucleoprotein A1 (F8W6I7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGIGDGYNGFGNDGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF