wanglab/gogpt-training-data huggingface dataset:
Protein: Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-) (Q13011)
Organism: Homo sapiens (Human)
Function: Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q62651}. Peroxisome {ECO:0000250|UniProtKB:Q62651}.
Interaction partners:
- Peroxisomal multifunctional enzyme type 2
- Peroxisomal targeting signal 1 receptor
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Enoyl-CoA delta isomerase 2
- Peroxisomal acyl-coenzyme A oxidase 1
- Sterol carrier protein 2
- Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Sequence:
MAAGIVASRRLRDLLTRRLTGSNYPGLSISLRLTGSSAQEEASGVALGEAPDHSYESLRVTSAQKHVLHVQLNRPNKRNAMNKVFWREMVECFNKISRDADCRAVVISGAGKMFTAGIDLMDMASDILQPKGDDVARISWYLRDIITRYQETFNVIERCPKPVIAAVHGGCIGGGVDLVTACDIRYCAQDAFFQVKEVDVGLAADVGTLQRLPKVIGNQSLVNELAFTARKMMADEALGSGLVSRVFPDKEVMLDAALALAAEISSKSPVAVQSTKVNLLYSRDHSVAESLNYVASWNMSMLQTQDLVKSVQATTENKELKTVTFSKL
Protein: Serine/threonine-protein kinase atg1 (EC 2.7.11.1) (Autophagy-related protein 1) (A2QIL5)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Function: Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P53104}. Preautophagosomal structure membrane {ECO:0000250|UniProtKB:P53104}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53104}.
Interaction partners:
Sequence:
MGLFHHSTLFLPLLRRSNEGPHGEMPIGHYTRLSEIGRGSFAVVYKGVHTRSRTYVAIKSVTMTKLSRKLKENLASEISILKQLHHPHIVALLDCHDTTSNIHLVMEFCALGDLSHFIKGRNTLQDSPYTRELIAKYPNPGEGAGLNEVIVRHFLKQLSSALRFLRDRDLIHRDIKPQNLLLCPAPSSYRSGAADVVPFKSSEDSFSPKTGLESLPMLKLADFGFARSLPATSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVVGRAPFRAVNHIELIKKIEQNKDQISFPSKNRVSEDIRELIRGLLKQHPMDRMNFDVYFAHKVLTEPIPGLVADDAPLGRSPADPTPRPGSGSRRSTPVQMKRENALSGGVRDEPATYPAAQRAMTQSPRPETPSTPMRRTGSAGTPHAAPNEPTPPASHPTRPSPVSLATAPGRQEHVDRPPTTTVVEQQRRRTASSGVPQVDKPVEKAKDEKEHAAQEVAFERDYVLVEKRAVEMNAFADELAYNPRMQGGQAGAVSRRSGAAPGTPPAGGSSPHASPSKAMQIISGRSRADSAHVRQNSYDRRYGQSPTSATSAISKALNMASGRLFGMSFSPPLTITKGGRSPPLAYNPFPAYPSAQTSLIVHADGGKPGANLDEDSKTVHDLEECATRSDVVYGFAEVKYKQLIPLAPSAATGYPGDPGSDAVDSADGGLTVDAIVTLSEEALVLYVKALSLLAKSMDIARVWWTRKSRGDTLSRADTGSTVAGNRINNVVQWVRNRFNEVLEKAEFVRLKLVEAQKRLPSDHPSHPSNLSVGSSLGSGTSADVVVSPDVTAEKLMYERALEMSRVAAINEITGEDLAGCEISYVTAIRMLEAILDDVEVSRPGQSGGADRADARRDNEDGGQNEPQAVILAKSANAWHSDIENPESPGVAPEEAGAAVESVHAPVQWTGQNAAVESGASLPCSGSHAAEIRTLTVRSMQDHAHFAPLLFSIFISSYSSSISCPSSCGHC
Protein: Transcription factor NAI1 (Basic helix-loop-helix protein 20) (AtbHLH20) (bHLH 20) (Transcription factor EN 27) (bHLH transcription factor bHLH020) (Q8S3F1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that regulates the expression of at least NAI2, PYK10 and PBP1. Required for and mediates the formation of endoplasmic reticulum bodies (ER bodies). Involved in the symbiotic interactions with the endophytes of the Sebacinaceae fungus family, such as Piriformospora indica and Sebacina.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- TSA1-like protein
- Beta-glucosidase 23
- Membrane protein of ER body 2
- Membrane protein of ER body 1
- PYK10-binding protein 2
- PYK10-binding protein 1
- MD-2-related lipid-recognition protein 3
- Jacalin-related lectin 34
- Beta-glucosidase 21
- Beta-glucosidase 22
Sequence:
MDDSSFMDLMIDTDEYLIDDWESDFPICGETNTNPGSESGSGTGFELLAERPTKQMKTNNNMNSTSSSPSSSSSSGSRTSQVISFGSPDTKTNPVETSLNFSNQVSMDQKVGSKRKDCVNNGGRREPHLLKEHVLAERKRRQKLNERLIALSALLPGLKKTDKATVLEDAIKHLKQLQERVKKLEEERVVTKKMDQSIILVKRSQVYLDDDSSSYSSTCSAASPLSSSSDEVSIFKQTMPMIEARVSDRDLLIRVHCEKNKGCMIKILSSLEKFRLEVVNSFTLPFGNSTLVITILTKMDNKFSRPVEEVVKNIRVALAE
Protein: Uncharacterized protein, isoform B (A0A0B4KG94)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVRETEDIAIEPIPAWLDQQKFEPILERDFPDLKKIKSFRLEPTAGKGENYTTLLLRANFELELNDGSEQSISYMAKILPNSGNRENVASWKVFYKERNTYGQYIPEFEQMYKDAGKKISFGPRYYESQIELDDELIVLEDLGKRGFRNVDRQNGLDIQHTEATLEKLAQFHAASAVRFELKGSYPEEYNQNLCSVVDSLKELRENQLKAYIDAFPLYDASHLTNDVQAYGSQADDMFQSFAPKIEGEFRVLNHGDAWCNNIMYQYDEAGKLAEVNFVDLQMSRFSSPAQDLLYLILSSTELDIKIAKFDYLIKFYHEKLIESLKLLKYPKPLPSLRSLHQSIFIYGDWILPIVSILLPLVLIDGGDDANMDSLMDGEGAGDKIRNNMFKNHRVIKHQKEILPWAHRRGAFEITK
Protein: Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1) (Q9Z2I0)
Organism: Mus musculus (Mouse)
Function: Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity). Essential for early embryonic development.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:27669901}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Calcium uptake protein 1, mitochondrial
- Mitochondrial sodium/calcium exchanger protein
- Calcium uptake protein 2, mitochondrial
- Calcium uniporter protein
- MICOS complex subunit Mic60
- Mitochondrial calcium uniporter regulator 1
Sequence:
MASILLRSCRGRGPARLAPPRAASPRGSLRDRACLSCTRTLGLTSRESVLSRCCTPAHPVYLCFKGEPLSCWTQRPECQGTAARTTWTPASARLVVTGPQYLPVRGWHSSSPLGEDSVIEKSLKSLKDKNKKLEEGGPVYSPPAQVVVRKSLGQKVLDELRHYYHGFRLLWIDTKIAARMLWRILNGHTLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVVVKLFPNMLPSTFETQSIKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGNATKDFSAFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLISEEGVDSLTVKELQAACRARGMRALGVTEDRLKGQLKQWLDLHLHHEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEKVDNKAKLEATLQEEAAIQQEHLEELKRASEAVKDIQPEVAEATLPGRPGPEPQPPVDDVILPSEVLTDTAPVLEGLKGEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYIEESAASKRLSKRVQQMIGQIDGLITQLETTQQDGKLGPSQSTPTGESVISITELISAMKQIKHIPEHKLISLTSALDDNKDGNINIDDLVKVIDLVNKEDVQISTTQVAEIVATLEKEEKIEEKEKAKEKAEKEAAEVKN
Protein: Accessory gland protein Acp76A (Q9VVW1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Responsible for physiological and behavioral changes in mated female flies. May play a role in accessory protein regulation and/or in the coagulation of seminal fluid to form a mating plug.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Accessory gland-specific peptide 26Aa
- Serpin 28F
- ACP53C14A
- Accessory gland protein Acp53Ea
- Accessory gland protein Acp29AB
- Accessory gland protein Acp62F
- Accessory gland protein Acp36DE
- ACP53C14B
- GH21475p
- Accessory gland protein Acp63F
Sequence:
MGNHQVIFLVLCTSLLFQNTIQQNVSFQLIREIDRYTPENFVLSVLNIEMILFEIHAAKAVESNNDLERSLIINFGYSEARQEVLDWGLRYKKASSAKFQMANKVAVSQKLPLSQKLRLVNEVLMTSAKKYDVTKDVRPSKLMDEWLSSHLDGVLANFVQEKKLNAGENIVAISGMTVTPLWASHFQSEINRYFVNNPGTGYASKDPTCVPMMHSLSSFETMSTDEAKGIYIPFSSANLGMLILLPRKGVTCKDILDNLNNQINVEYNDHKDVHLLLPIFKEKFDYNIAKFFNGINIEDTFKDSAFKSKAKIKINNFRVNHGIRFQPILRLEVVDDIDTGKTETFEVNRPFVFVIKDKINVYAVGRIENLDGLTDKVNCSKKYADL
Protein: ESCRT-III subunit protein (Q5AH99)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004608}.
Interaction partners:
- Vacuolar-sorting protein SNF7
- ESCRT-III subunit protein
- ESCRT-III subunit protein
- ESCRT-II subunit protein
- Vacuolar protein sorting-associated protein 4
- Vacuolar protein-sorting-associated protein 36
- Vacuolar-sorting protein SNF8
- Uncharacterized protein
- Ubiquitin-binding ESCRT-I subunit protein
- Vacuolar protein-sorting protein BRO1
Sequence:
MGQQPSTPKITAQDRAIFQLKQQRDKLKQYQKRLNTIIEKQTELAKKAVLNKQPEKAKFYLRSKKQQESVISTTFDQLNNLEKLIGTIEFKLIEKDVVYGLQQGNKVLQKLNNEMQVEKIDALIDQLEDEKLKVDEVSELLGGVDQLNRSEEDEVDKEFQTLQEEIHGKIKQVTEEEEEESNLPKVPNTKPMPEAPSNEIEEHTPQKETKHEPIAI
Protein: Gustav (Q962F3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHNFQLTVVFLALFTFSSSFGYRSEHPHRKPKHSNRSSPTTTMTTDSTSTSFMTTDSTPSETESTSDTSTEESTQISDFTESSTESSTTAKIFLKDNEISKPENSNTLLISVYGIVITLAILVALIYCIRRHYGSYSVKEQCKPIESTAYFNNIKY
Protein: Probable 26S proteasome subunit YTA6 (Tat-binding homolog 6) (P40328)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Uncharacterized protein YPR096C
- Vacuolar protein sorting-associated protein IST1
Sequence:
MAHEKFSIPENFTLAQSLQLLYSVVKNQYKNLADLIINSKGNKDTVTYGKIHKNLDTLLVYVNEGLRKIEKTYTLKKGLGNLVVDHPELRSIIEDFQILGQDIRIARRKAETLMAEGNGSPSLSSSSSVLGLGTGNGLRFPKLWRMGSKRDKLKEADEKEAKINKQADNIRRARKLEEEKKLGAKLQYERDLELQREKLIELKVKEKVEFEVAQKLEEERVKREEEERKHREQAEKKRISTLKHERKTNYKSRASLDNFSSSSKSSGKIDNSLIKRRSLDVVRTSGERVRTPVRKSMEAAEIGMAAQLAWSQYQNGANHSKVSNNGSHSNELQIRYKPTPPLKKRYDYKKPTVNRPIIKSPTLNRQNSKSSRNIPTNSKLKASKSNTNKVSRRNEQNLEPSSPVLVSATAVPAESKPMRSKSGTPDKESSASSSLDSRKEDILKSVQGVDRNACEQILNEILVTDEKVYWEDIAGLRNAKNSLKEAVVYPFLRPDLFKGLREPVRGMLLFGPPGTGKTMIAKAVATESNSTFFSVSASSLLSKYLGESEKLVRALFYMAKKLSPSIIFIDEIDSMLTARSDNENESSRRIKTELLIQWSSLSSATAQSEDRNNTLDSRVLVLGATNLPWAIDDAARRRFSRKLYIPLPDYETRLYHLKRLMAKQKNSLQDLDYELITEMTEGFSGSDLTSLAKEAAMEPIRDLGDKLMFADFDKIRGIEIKDFQNALLTIKKSVSSESLQKYEEWSSKFGSNGS
Protein: Oxalate-binding protein (Putative oxalate decarboxylase) (Q9X113)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Binds oxalate.
Interaction partners:
Sequence:
MKEGTGMVVRSSEITPERISNMRGGKGEVEMAHLLSKEAMHNKARLFARMKLPPGSSVGLHKHEGEFEIYYILLGEGVFHDNGKDVPIKAGDVCFTDSGESHSIENTGNTDLEFLAVIILL
Protein: Glycolipid 2-alpha-mannosyltransferase 1 (EC 2.4.1.-) (Alpha-1,2-mannosyltransferase 1) (Q00310)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Involved in O-glycosylation of cell wall and secreted proteins. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Mainly responsible for the addition of the second mannose residue in an O-linked mannose pentamer. Can also substitute for MNT2 by adding the third mannose residue. Important for adherence to host surfaces and for virulence.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Glycolipid 2-alpha-mannosyltransferase 2
- Probable mannosyltransferase MNT3
- Initiation-specific alpha-1,6-mannosyltransferase
- Alpha-1,2-mannosyltransferase MNN2
Sequence:
MASTRSNARLIRFGIFALVLIGCGYILTRGSSFQPPNYQQTQSPAAHEKQTGNVAAGGGAGSGSAGAQVPLGKNRGPIPKAIMGAGEGGSDAPVPQQDIPDSYTLNDKIKATFVTLARNSDLYSLAESIRHVEDRFNKKFHYDWVFLNDEEFNDEFKETVGSLVSGNTKFGLIPKEHWSYPPWIDQEKAALVREQMREKKIIYGHSESYRHMCRFESGFFWRQEILNDYDYYWRVEPDIKLYCDIDYDIFKWMKDNNKDYAFTISLPEYKETIPTLWDTTKEFIEKNPQYLAQNNLMDWVSDDKGQTYNGCHFWSNFEIGSLAFWRSEAYRKYFEHLDKAGGFFYERWGDAPVHSIAAALFLPREKIHFFEDVGYYHVPFTNCPVDKEVRKARNCNCDPNKDFTWRGYSCTTKYYTLNNFKRQKGWEKYTA
Protein: Guanine nucleotide-binding protein-like 3 homolog (Nucleostemin 1) (Nucleostemin homolog) (Q8MT06)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play a role in regulating cellular proliferation.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:18628395}.
Interaction partners:
- Nucleolar GTP-binding protein 2
- Pescadillo homolog
- RRM domain-containing protein
- Ribosome assembly factor mrt4
- Nucleolar GTP-binding protein 1
- Ribosome biogenesis protein BOP1 homolog
- Nucleolar complex protein 2
- Probable rRNA-processing protein EBP2 homolog
- Probable ATP-dependent RNA helicase pitchoune
- Ribosome biogenesis protein WDR12 homolog
Sequence:
MALKRLKTKKSKRLTGRLKHKIEKKVRDHNKKERRAAKKNPKKGSKKQKLIQIPNICPFKDDILKEVEEAKQRQEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKNAVTKEQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLNKADLVPRENLNNWIKYFRRSGPVTAFKASTQDQANRLGRRKLREMKTEKAMQGSVCIGAELLMSMLGNYCRNKGIKTSIRVGVVGIPNVGKSSIINSLTRGRSCMVGSTPGVTKSMQEVELDSKIKLIDCPGIVFTSGGENSHAVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYDITNYDTFEEFFAKKAARMGKFLKKGVPDVVAAARSVLNDWNTGKIKYCTQPPEVQEGQSVHISASIVHSEAREFDVENFESMETEILEHCAVKTDDIMEITSTGPLEIRQPREEAEPADKITASLVIDEKEKPAKGRKRKLDEEKEKVDPSLLLEENQSLNKGIKQMQKLKKKQNVRNEKKISKITDVLDSFSLGPSSSKAEKYDFDEDYVIE
Protein: Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 (EC 2.7.11.1) (O64556)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MGNFNFLPLVSFASFVVVLVLVCAQDQSGFVSIDCGIPEDSSYYDEKTDIKYISDAAFVESGTIHSIDSKFQKKNLEKQFQKVRSFPEGKKNCYDVQPPQGKGFKYLIRTRFMYGNYDNLGKAPDFDLYLGVNLWDSVTLENSTTIVTKEIIYTLRSDKVHVCLVDKERGTPFLSVLELRLLKNNIYETASDSLMLYRRWDLGATGDLPARYKDDIFDRFWMPLMFPNFLILNTSLMIDPTSSNGFLPPSVVMSTAVAPMNSSIEQIMVYWEPRDPNWKFYIYIHFAEVEKLPSNETREFSVFLNKEQIDTTSVFRPSYLYTDTLYVQNPVSGPFLEFVLRQGVKSTRPPIMNAIETYRTNEFLDLPTDQNDVDAIMKIKTKYKVKKNWLGDPCAPFGYPWQGINCSYTANNPPRIISVNLSFSGLTGQIDPVFITLTPLQKLDLSNNRLTGTVPDFLANLPDLTELNLEENKLTGILPEKLLERSKDGSLSLRVGGNPDLCVSDSCRNKKTERKEYIIPSVASVTGLFFLLLALISFWQFKKRQQSVKTGPLDTKRYYKYSEIVEITNNFERVLGQGGFGKVYYGVLRGEQVAIKMLSKSSAQGYKEFRAEVELLLRVHHKNLIALIGYCHEGDQMALIYEYIGNGTLGDYLSGKNSSILSWEERLQISLDAAQGLEYLHNGCKPPIVHRDVKPTNILINEKLQAKIADFGLSRSFTLEGDSQVSTEVAGTIGYLDPEHYSMQQFSEKSDVYSFGVVLLEVITGQPVISRSRTEENRHISDRVSLMLSKGDIKSIVDPKLGERFNAGLAWKITEVALACASESTKTRLTMSQVVAELKESLCRARTSGDSGDISFSEPTEMNVSMTVDPGVLPQPR
Protein: Transcription activator GLK2 (GBF'S PRO-RICH REGION-INTERACTING factor 2) (Golden2-like protein 2) (AtGLK2) (Q9FFH0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that functions with GLK1 to promote chloroplast development. Acts as an activator of nuclear photosynthetic genes involved in chlorophyll biosynthesis, light harvesting, and electron transport. Acts in a cell-autonomous manner to coordinate and maintain the photosynthetic apparatus within individual cells. May function in photosynthetic capacity optimization by integrating responses to variable environmental and endogenous cues. Prevents premature senescence.
Subcellular location: Nucleus {ECO:0000269|PubMed:23459204}.
Interaction partners:
- Transcription factor PIF5
- Light-mediated development protein DET1
- NAC domain-containing protein 92
- Tetrapyrrole-binding protein, chloroplastic
- Magnesium-chelatase subunit ChlH, chloroplastic
- Pentatricopeptide repeat-containing protein GUN1, chloroplastic
- Transcription factor HY5
- Protochlorophyllide reductase B, chloroplastic
- Chlorophyll a-b binding protein 2.4, chloroplastic
- Putative GATA transcription factor 22
Sequence:
MLTVSPAPVLIGNNSKDTYMAADFADFTTEDLPDFTTVGDFSDDLLDGIDYYDDLFIGFDGDDVLPDLEIDSEILGEYSGSGRDEEQEMEGNTSTASETSERDVGVCKQEGGGGGDGGFRDKTVRRGKRKGKKSKDCLSDENDIKKKPKVDWTPELHRKFVQAVEQLGVDKAVPSRILEIMNVKSLTRHNVASHLQKYRSHRKHLLAREAEAASWNLRRHATVAVPGVGGGGKKPWTAPALGYPPHVAPMHHGHFRPLHVWGHPTWPKHKPNTPASAHRTYPMPAIAAAPASWPGHPPYWHQQPLYPQGYGMASSNHSSIGVPTRQLGPTNPPIDIHPSNESIDAAIGDVISKPWLPLPLGLKPPSVDGVMTELQRQGVSNVPPLP
Protein: Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (hFAST-1) (Forkhead activin signal transducer 2) (Fast-2) (O75593)
Organism: Homo sapiens (Human)
Function: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
Subcellular location: Nucleus.
Interaction partners:
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 3
- Mothers against decapentaplegic homolog 4
- Dr1-associated corepressor
- Homeobox protein MIXL1
- POU domain, class 5, transcription factor 1
- Eomesodermin homolog
- Homeobox protein NANOG
- Transcription factor SOX-2
- Catenin beta-1
Sequence:
MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEGFSIKSLLGGSGEGAPWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGPSTLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGPPGLLCDLDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL
Protein: AP2-like ethylene-responsive transcription factor TOE3 (Protein TARGET OF EAT 3) (Q9FH95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). May regulate negatively the transition to flowering time and confers flowering time delay.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- 1-aminocyclopropane-1-carboxylate oxidase 4
- Squamosa promoter-binding-like protein 9
- Squamosa promoter-binding-like protein 3
- Agamous-like MADS-box protein AGL8
- Squamosa promoter-binding-like protein 10
- Squamosa promoter-binding-like protein 15
- MADS-box protein SOC1
- TIC-like protein
- Protein TIME FOR COFFEE
- Squamosa promoter-binding-like protein 5
Sequence:
MWNLNDSPDHHEESDSRGNPVGHVSNGMSQSATWLPFVLPVTRNFFPAQSMEPGVRWSGFNSVGKSDPSGSGRPEEPEISPPIKKSRRGPRSRSSQYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAYDRAAIKFRGVDADINFDIEDYLDDLKQMGNLTKEEFMHVLRRQSTGFPRGSSKYRGVTLHKCGRWESRLGQFLNKKYVYLGLFDTEIEAARAYDKAAIKCNGKDAVTNFDPKVYEEEEDLSSETTRNGHNLGLSLGESSSEEFRLKSDIASIRSRIRDEERLLGSDLSLAMMTTTVRSEKQQSDGGGNRVVGMAASSGFSPQPSPYRIPRTFHFSRP
Protein: Type III secretion protein PcrV (G3XD49)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Translocator outer membrane protein PopD
- Translocator protein PopB
- Regulatory protein PcrH
- Regulator in type III secretion
- Type 3 secretion system needle filament protein
- Type 3 secretion system secretin
- Type III secretion outer membrane protein PopN
- Exoenzyme T
- Secreted exoenzyme S
- Adenylate cyclase ExoY
Sequence:
MEVRNLNAARELFLDELLAASAAPASAEQEELLALLRSERIVLAHAGQPLSEAQVLKALAWLLAANPSAPPGQGLEVLREVLQARRQPGAQWDLREFLVSAYFSLHGRLDEDVIGVYKDVLQTQDGKRKALLDELKALTAELKVYSVIQSQINAALSAKQGIRIDAGGIDLVDPTLYGYAVGDPRWKDSPEYALLSNLDTFSGKLSIKDFLSGSPKQSGELKGLSDEYPFEKDNNPVGNFATTVSDRSRPLNDKVNEKTTLLNDTSSRYNSAVEALNRFIQKYDSVLRDILSAI
Protein: Protein S100-A14 (S100 calcium-binding protein A14) (S114) (Q9HCY8)
Organism: Homo sapiens (Human)
Function: Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11944983}.
Interaction partners:
- Protein S100-A16
- Hornerin
Sequence:
MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVRGH
Protein: Cysteine-rich secretory protein LCCL domain-containing 2 (Cysteine-rich secretory protein 11) (CRISP-11) (LCCL domain-containing cysteine-rich secretory protein 2) (Q9H0B8)
Organism: Homo sapiens (Human)
Function: Promotes matrix assembly.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
Sequence:
MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVKDYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKAKIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ
Protein: Plasma membrane fusion protein prm1 (Q9P771)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Cell fusion protein dni1
- Probable peptide methionine sulfoxide reductase
- Peptidyl-prolyl cis-trans isomerase 9
Sequence:
MASSYLSLAARLSQCWISPWSLCCLYILMQFFLFTKDLNTKIGDFVNDEQATCNYIQEKVDILLDSPSLIANAAVRVAKDGIQSTVKIILSGISDSLIAAENVFIFFIEFSYGTYLCLIQLAIDGILDAVADVGEEIGTAVNDTLHAIADEIEDTVSSLNEVFQSAEDSLEKVASWLGEDINLPNVSIPEIQSLRNFTLSSSYDTEFEKLKAGVNFDSAINATKAAISKPFSSARNLILEKVSNYSFDTSMVSSPNKTHVVVCSTDDLTAISSFILSSIYKIRKVVIISLLIIIAGLFLISSIYEIWKWCRIRHKAFLLDEHIRSNKFEDTRDLISYIESPISWNLKYFISALPLPCFLSVQLRWFITYIFHPPAAMILFISCTSFISGILQLVLLNNIREDGSVISALAQNSFHKVESALANVSVAWANSTNQIILKNQENINNNMFGSIHNTTLSLNSTLNTFMNELNSSMTSAFGDTFLASTVQNVMNCLLYRKIENFEEVLTWVYNKSHIELPLLPTDILSKSIDNQTIYSSLYSSLNSSNSTVSFSGIFDRVEKSVISELNFSFLFFLLWLLICAFGLIGVLSSWLKSLFLSLLDLVIPNPKENITLPVQSLAFPVTKSCRPPPIPPRESHVYDFQNFQYEEDDCIDYKRSLGLISLSSDLAIDIPISPAIISDIQFNSITTESEETTYLLKEKQDRY