wanglab/gogpt-training-data huggingface dataset:
Protein: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic (1-deoxyxylulose-5-phosphate reductoisomerase) (DOXP reductoisomerase) (DXP reductoisomerase) (EC 1.1.1.267) (Q8IKG4)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Subcellular location: Plastid, apicoplast {ECO:0000250|UniProtKB:O96693}.
Interaction partners:
- 1-deoxy-D-xylulose-5-phosphate synthase
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, apicoplast
- Protein phosphatase PPM5, putative
Sequence:
MKKYIYIYFFFITITINDLVINNTSKCVSIERRKNNAYINYGIGYNGPDNKITKSRRCKRIKLCKKDLIDIGAIKKPINVAIFGSTGSIGTNALNIIRECNKIENVFNVKALYVNKSVNELYEQAREFLPEYLCIHDKSVYEELKELVKNIKDYKPIILCGDEGMKEICSSNSIDKIVIGIDSFQGLYSTMYAIMNNKIVALANKESIVSAGFFLKKLLNIHKNAKIIPVDSEHSAIFQCLDNNKVLKTKCLQDNFSKINNINKIFLCSSGGPFQNLTMDELKNVTSENALKHPKWKMGKKITIDSATMMNKGLEVIETHFLFDVDYNDIEVIVHKECIIHSCVEFIDKSVISQMYYPDMQIPILYSLTWPDRIKTNLKPLDLAQVSTLTFHKPSLEHFPCIKLAYQAGIKGNFYPTVLNASNEIANNLFLNNKIKYFDISSIISQVLESFNSQKVSENSEDLMKQILQIHSWAKDKATDIYNKHNSS
Protein: Probable malonic semialdehyde reductase RutE (EC 1.1.1.298) (P75894)
Organism: Escherichia coli (strain K12)
Function: May reduce toxic product malonic semialdehyde to 3-hydroxypropionic acid, which is excreted. RutE is apparently supplemented by YdfG. Required in vivo, but not in vitro in pyrimidine nitrogen degradation.
Interaction partners:
- Putative carbamate hydrolase RutD
- Ureidoacrylate amidohydrolase RutB
- 3-aminoacrylate deaminase RutC
- Pyrimidine monooxygenase RutA
- FMN reductase RutF
- NADP-dependent 3-hydroxy acid dehydrogenase YdfG
- Putative pyrimidine permease RutG
Sequence:
MNEAVSPGALSTLFTDARTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFTRTAEGKERLRPALSSGNLQKTLTAPVTAIVAWDSEFYERLPLLFPHGDARSWFTSSPQLAEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFTGSTLKSNLLINIGYGDSSKLYARLPRLSFEEACGLL
Protein: Copper homeostasis protein cutC homolog (P34630)
Organism: Caenorhabditis elegans
Function: Involved in copper homeostasis. Affects body morphology and length, egg laying and brood size.
Interaction partners:
- Copper transport protein ATOX1
- P-type Cu
- Translation factor GUF1 homolog, mitochondrial
Sequence:
MTETESQKQIKLEICIDNLESAENAVAGGADRLEVCSALQLGGLTPSVGFVSILSYKYPDIPLYCMIRQRAGDFVYNEDEMAANMEDVEWLKKAGATGFVFGALTSAGSLDRTSCQSIIETARPHPVTFHRAIDVAYDWKTCLEDAIDVGFKAVLTSGQEPSALDGVYIIREMQELHKGKIDVLAGCGVNSSNVANLVEWTKCHWYHASASVAKKNAPLNKVSMGKQDNQPSRVTSLEEVRMLKATLAPV
Protein: Uncharacterized protein PF3D7_1404800 (Q8IM46)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKILFNNTFELFCLFVFVTWALFLNNNGILYPVHCLKSAGDTYVDTLRGSNFNNEFIDLLSTRDICNTIKNYITREQIKCAISYDVLNISNIINSLEKTLLRDHNIIINGKEDILKKYLNTFLTLYIKRQSEDVNNFIKKFSNSKLDVVINYRYYEEKFLSEYEEIDSLKKGFSNHISEIKDILNNISSSNNYKKKSGVIYFPDVKETLYSKIQILKEILCKLRNKVSFMYNINFALDEFKENFDKQVYNFKGKEGLNDFVRITSDITNPTSTFTNVVDINKFNVNTQMDEIQNGTLSKEHLNDFRRNIINLDVHIRDPSSFCVNQVENPTEMNINNPCNNNDGNNINCKDLVEEDAMLNHFSFLLHHLEKMTCILIFSLKNKISSARDDIQKDINKMESELINVSNEINRLDIVVDVPQHHILNYHNKNENKVFNLMNIKNEYYEYLGGHNKINNNFDDFDNTLMLLERKTNWIKDQNIMTYGDREDIHEAISSTLEMIDKLKDMYVTENFNLLITYENLYKEINLFLYNKQYNISEEAYIYAWNSLENFKGKKLLTEGIDRLLGSVMSISYVIKYVKVANKHLNPQICFNLNKLSNAFMNIEEKLVLYRNQFYRLNHDITTLKLFKNNIEKLGYAYRDNMNKVHINMDTYNIATENLQHEIDNILENISDVLYEDMLINELKTMRATWKNFVYVKYDYFKQNNKLIEEFDENKLIIFPPQFGLMKQSEQTNIRNDNNNNNNNNNNNSNNNNNNNNNNKDNSVASLGSSILTRTSSPDNYLIGQNFIKSPYYNLLYEFATEKINCAKTPEERIKSFGEIYRTIDRVSSVIKENRKNLRSKYDNMRIEILKLIDYRKHTFEETKDVHKELIRLEGFILNTLDNLFAKRMTLSVQMKNSVEMLKGSLYKDKLPDYCKAVEMFIPKYFLTMTRWRNFLLEYRKIMPSRVISKFYST
Protein: Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) (Q13206)
Organism: Homo sapiens (Human)
Function: Putative ATP-dependent RNA helicase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:33657088}. Nucleus {ECO:0000269|PubMed:36779599}. Nucleus, nucleolus {ECO:0000269|PubMed:33657088}.
Interaction partners:
- ESF1 homolog
- ATP-dependent RNA helicase DDX18
- Activator of basal transcription 1
- Nucleolar MIF4G domain-containing protein 1
- Something about silencing protein 10
- Nucleolar protein 6
- Ribosomal RNA processing protein 36 homolog
- U3 small nucleolar RNA-associated protein 18 homolog
- Protein RRP5 homolog
- Bystin
Sequence:
MGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYSTPATLEQNYIVCELQQKISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQLLQKKVPVKEIKINPEKLIDVQKKLESILAQDQDLKERAQRCFVSYVRSVYLMKDKEVFDVSKLPIPEYALSLGLAVAPRVRFLQKMQKQPTKELVRSQADKVIEPRAPSLTNDEVEEFRAYFNEKMSILQKGGKRLEGTEHRQDNDTGNEEQEEEEDDEEEMEEKLAKAKGSQAPSLPNTSEAQKIKEVPTQFLDRDEEEEDADFLKVKRHNVFGLDLKDEKTLQKKEPSKSSIKKKMTKVAEAKKVMKRNFKVNKKITFTDEGELVQQWPQMQKSAIKDAEEDDDTGGINLHKAKERLQEEDKFDKEEYRKKIKAKHREKRLKEREARREANKRQAKAKDEEEAFLDWSDDDDDDDDGFDPSTLPDPDKYRSSEDSDSEDMENKISDTKKKQGMKKRSNSEVEDVGPTSHNRKKARWDTLEPLDTGLSLAEDEELVLHLLRSQS
Protein: Alcohol dehydrogenase 1 (EC 1.1.1.1) (Alcohol dehydrogenase A subunit) (P06757)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm.
Interaction partners:
- S-formylglutathione hydrolase
- Hydroxyacid-oxoacid transhydrogenase, mitochondrial
- S-formylglutathione hydrolase
- Cytochrome P450 2E1
- Aldehyde dehydrogenase 1A1
- Aldehyde dehydrogenase
- All-trans-retinol dehydrogenase [NAD
- Aldehyde dehydrogenase, mitochondrial
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Vasopressin-neurophysin 2-copeptin
Sequence:
MSTAGKVIKCKAAVLWEPHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHAVSGSLFTPLPAVLGHEGAGIVESIGEGVTCVKPGDKVIPLFSPQCGKCRICKHPESNLCCQTKNLTQPKGALLDGTSRFSCRGKPIHHFISTSTFSQYTVVDDIAVAKIDAAAPLDKVCLIGCGFSTGYGSAVQVAKVTPGSTCAVFGLGGVGLSVVIGCKTAGAAKIIAVDINKDKFAKAKELGATDCINPQDYTKPIQEVLQEMTDGGVDFSFEVIGRLDTMTSALLSCHSACGVSVIVGVPPSAQSLSVNPMSLLLGRTWKGAIFGGFKSKDAVPKLVADFMAKKFPLEPLITHVLPFEKINEAFDLLRAGKSIRTVLTF
Protein: Noelin-2 isoform X2 (Noelin-2a isoform X2) (Olfactomedin 2a) (A0A286Y8W4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MHLFSAMFLLLMLSIIPCEALYPSPEEGWQIYSSAQDADGKCICTVVAPAQNMCNRDPRSRQLRQLMEKVQNITQSMEVLDLRTYRDLQYVRDTENLMKTVDGKLKTASENPRSLNPKSFQELKDKVTQLLPLLPVLEQYKADARMILRLREEVRNLSLVLMAIQEEMGAYDYEELRQRVLLLETRLHSCMQKLGCGKLTGVSNPITVRASGSRFGSWMTDTMIPSSDNRVWSMDGYFKGRRVLEYRTMNDFMKGQNFVQHLLPHPWAGTGHVVYNGSLYYNKYQSNILIKYHFRSRSVLVQRSLSGAGYNNTFPYSWGGSSDIDLMADENGLWAVYTTIPNAGNIVISRLEPQSLEVLQTWDTGFPKRSAGESFMICGTLYVTNSHLAGAKIYFAYYTNTSTYEYTDIPFHNQYSHISMMDYNPRERVLYTWNNGHQVLYNVTLFQVIKTAED
Protein: Phosphatidate cytidylyltransferase 1 (EC 2.7.7.41) (CDP-DAG synthase 1) (CDP-DG synthase 1) (CDP-diacylglycerol synthase 1) (CDS 1) (CDP-diglyceride pyrophosphorylase 1) (CDP-diglyceride synthase 1) (CTP:phosphatidate cytidylyltransferase 1) (P98191)
Organism: Mus musculus (Mouse)
Function: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (By similarity). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (By similarity). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis. Positively regulates the differentiation and development of adipocytes.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16023307}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
- Cardiolipin synthase
- Membrane-bound glycerophospholipid O-acyltransferase 2
- Phospholipase D1
- Phospholipid phosphatase 2
- Phosphatidate cytidylyltransferase 2
- Phospholipase D2
- Phosphatidate phosphatase LPIN1
- 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
Sequence:
MLELRHRGGCPGPGGAGAPPPREGEAAGGDHETESTSDKETDIDDRYGDLDARGDSDVPEVPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFLIIYMGSFMLMLLVLGIQVKCFHEIITIGYRVYHSYDLPWFRTLSWYFLLCVNYFFYGETVADYFATFVQREEQLQFLIRYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTHVTLLITVTQSHLVIQNLFEGMIWFLVPISSVICNDITAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFSTVIFGFIAAYVLSKYQYFVCPVEYRSDVNSFVTECEPSELFQLQNYSLPPFLQAVLSRETVSLYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLNIYRTLKIHLTEKGILQPTLKV
Protein: BTB/POZ domain-containing protein 9 (Q9W2S3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for the homeostatic regulation of sleep and motor activity, by depressing hyperactivity and wakefulness. May function, at least in part, by ensuring dopamine biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22658601}. Note=Localized to distinct puncta in neuronal cytoplasm. {ECO:0000269|PubMed:22658601}.
Interaction partners:
- Caspar, isoform A
- GM09977p
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL22m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein bL19m
Sequence:
MSSQGHHKMSGGGKKGAMEQDYTDVVDLGDRFSADMARLCMNEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPLEVPLEAFKVLLRYIYSGTLLLSTLDEDSTIDVLGMANQYGFQDLEMAISNYLRQYLALDNVCMILDAARLYNLEELTEVCLMFMDRNAGDLLLHNSFNTLSKESLEEVLRRDCFFAPEVQIFLAVWKWSRFNSNVDFKSVVSYVRLPLMNLEHLLQVVRPSGILDPDKILDAIDERSTSKALPYRAALWPEENVAAETFLSRCIQGECRDALLDGDVTTYDMENGYTRHCITDSKDAGIVVELGTFCMINHIRMLLWDRDSRAYSYYVEVSGDQQHWDRVVDYSDYHCRSWQYLYFEARPVRFIRLVGTQNTVNRVFHVVGLEAMHTAKVPRLVNHFVAPKTNVATVEMSAIVTDGVSRTRNALINGDYVRYDWDSGYTCHQLGSGEIVVRLGQPYYLGSMRLLLWDCDDRTYSFYIEISTNRKEWQMVVDRRNDRTRSWQNFHFTPRPVVYIRIVGTRNTANEIFHCVHLECPTQDKNYLKKIADMEKEREKREKEKKTAKTDDDNIASTSGSSLASGHAESPSTSSSSSQSVLRSIHWPPQTREVAVAPLTPPALSPPGTPALPAPLTPATSSPHNNHEQNQPSNISADASHHTSPSSRSNPSPSLSRSRSQSAELEPVPPLVELDTRETL
Protein: cGMP-dependent protein kinase interacting domain-containing protein (G5EGT0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MGQDDEDDAHMLQAKQQITFNVVNKRKDQLRRWQSSEMNAEAARRTKRPKVQFQDSDIFLSACMSGDEEEVEELLNKGANINTCTVDGLTALHQSVIDSKPEMVRFLCEKGADVNAQDNEGWTPLHAAACCGNVAIVRYLCQHGADLSIVNSDKELALDLAVDEQCRDYLDDDYKRQMIDLDACRDQELQTMLKDVNMWMSQGEYRDIPHHRTGGTAMHVAAGRGYTQLLELLIKAGGNVRAQDVEGWTPLHAAAHWAERDACKILLENGAELSDLTFTGADVLGVADKECIDYLVELADTVKVQNKRKSPGSGSQPPTSILQEKNHRMPSHEEHVLTSERKRDLQHKDQHSENEFLHSHPSTASVGSTTSSNTNTTTTTIVIGENDISAAQKDSRESSKESAVDDEEYVAEDEMEEAEEDEEEEDVEEEEEEKSEAELKNGKEISPLRSETTSSRSISITRSLDGYTDRSSSGRETSAEMSEAASSASTGTTSSSSRFTSSTPSSQRSAAGSVHTETPRSSMRFKENSSSVGSGDQNVSATIPIVPLSAPPKAVHQSPSSWINRGVPLSSRSSTSSVTRSSSTPVSEIISPPSSIHSQLSFPSVSNTTTTTATVAPTSSTVPSTPVSNVMAATISSTAKNTPSPAGSVTTINATFSKPSRWQSKTVTESEAERRNNSRMQRQHRRSTQGVTKEQLEEASKFATDEVARRNSQVLSTYPNSLHARLASEEKDLSSTSDDLKDGDVSTTATVSLINSPNSNSANVRRKSQGLSISRSNRRATGPVNPEDLAPAMSLRLATAQPYSPASVRSNAGTLPTMTSRFSEKAQSLPPASNGMSSTQPLSTRSAIVAGLSSAPSMRTTAPLSSTATSSRFMPSSSLSSNGSSANQQPSSIYGLQSRPTETNLNYKALFEKERSECERLRREMEEMRRSQTADSYRGASTQLAWRARNASPSAQPHNLSVAKSTSLASFDENERRSMERKISDLELQLKTATNLRMENQRLKEENGALVRVISKMTI
Protein: Small nuclear ribonucleoprotein polypeptide A' (H0YKK0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKF
Protein: Magphinin-gamma (Q99PH6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDRRNDHGHRVPTFQGPLPPAGSLGLPFSPDVQSETTEKDPPIASRSKKNKNKKNSIKPMDKTTPAPPPVPSANDNASNKPKVTLQALNLPMFTQISQASATTEAPNIQASVTSQTQKAKTMRVTPKVSLTGSEDATTQLKPPLQALNLPVTTPTIQTPVANESANSLASTAVNKSKKASTANNAANKTVPSAAEISLASAATHTATTQGQAAKETGSIQTIAATARSKKNSKGKRTPAKTTNTDNEYVEASNAIEASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASNRQTEVSSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTEASSRQTEASSRQTEASSRQTEASSRQIEASAAAVRPKKPRGKKGNNKGSNSASEPSEAPPAIQTVTNHALSVTVRIRRGSRARKAANKNRATESQAQIAEQGAQASEASISALETQVAAAVQALADDYLAQLSLEPTTRTRGKRNRKSKHPNGEERTGNNYRRIPWGRRLPPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLKDVIQEYEDYFPEIIERASYALEKMFRVNLKEIDKQNNLYILISTQESSAGIMGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLHPGVKHSLFGEVKKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACKACSPCLQITLTATILPMEPMCSFGIVVHAAA
Protein: Probable mannosyltransferase MNT3 (EC 2.4.1.-) (P87207)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Glycolipid 2-alpha-mannosyltransferase 2
- Glycolipid 2-alpha-mannosyltransferase 1
- Putative alpha-1,3-mannosyltransferase MNT4
Sequence:
MLWHLVFILIAILLLTFSPKIESLFKSFTINKPTKTTCYQYTTREQLKSILESDTHETNFCIEKPSISPPKTNSTLLMLCRNSDVFSVLETIQNIQDRFNDKYNYDYTFLNDVPFNYEFIYLVSSIIPHGKINFGLIPIEHWSYPSHINISLATEIRQNYANVPYGDSESYRHMCRFYSGFFYKHELVKQYQYYWRIEPGIKIYCDIDYDVFEYMIINDKKYGFVISLFEYSETIPTLWNHVVQYINDNEIKSELLPLLTNKYNWYNLCHFWSNFEIANLDIFNNDDYENFFQYLDNLGGFYYERWGDAPIHSIAIALFLQKKDIHWFENIGYYHVPYLQCPQDIDLYVKNKCTCNPDEDFTWSDLSCTNHFLNILHN
Protein: Forkhead box protein M1 (Forkhead homolog 16) (Winged-helix transcription factor Trident) (O08696)
Organism: Mus musculus (Mouse)
Function: Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (By similarity). Plays a role in the control of cell proliferation (By similarity). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2 (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Interaction partners:
- Catenin beta-1
- Serine/threonine-protein kinase PLK1
- Protein lin-54 homolog
- Protein lin-9 homolog
- Myb-related protein B
- Protein lin-37 homolog
- Cyclin-A2
- Protein lin-52 homolog
- Cyclin-dependent kinase 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Sequence:
MRTSPRRPLILKRRRLPLPVQNAPSETSEEEAKRSPAQPEPAPAQASQEVAESSSCKFPAGIKIINHPTTPNTQVVAIPSNADIQSIITALTAKGKESGTSGPNRFILISSGGPSSHPSQPQAHSSRDSKRAEVITETLGPKPAAKGVPVPKPPGAPPRQRQESYAGGEAAGCTLDNSLTNIQWLGKMSSDGLGPCSVKQELEEKENCHLEQNRVKVEEPSGVSTSWQDSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRHLTLDQVFKPLEPGSPQSPEHLESQQKRPNPELHRNVTIKTEIPLGARRKMKPLLPRVSSYLEPIQFPVNQSLVLQPSVKVPFRLAASLMSSELARHSKRVRIAPKVLLSSEGIAPLPATEPPKEEKPLLGGEGLLPLLPIQSIKEEEMQPEEDIAHLERPIKVESPPLEEWPSPCASLKEELSNSWEDSSCSPTPKPKKSYCGLKSPTRCVSEMLVTKRREKREVSRSRRKQHLQPPCLDEPDLFFPEDSSTFRPAVELLAESSEPAPHLSCPQEEGGPFKTPIKETLPVSSTPSKSVLSRDPESWRLTPPAKVGGLDFSPVRTPQGAFGLLPDSLGLMELNTTPLKSGPLFDSPRELLNSEPFDLASDPFGSPPPPHVEGPKPGSPELQIPSLSANRSLTEGLVLDTMNDSLSKILLDISFPGLEEDPLGPDNINWSQFIPELR
Protein: D-malate dehydrogenase [decarboxylating] (EC 1.1.1.83) (D-malate degradation protein A) (D-malate oxidase) (P76251)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D-malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in those conditions. Appears to be not able to use L-tartrate as a substrate for dehydrogenation instead of D-malate.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Acetolactate synthase isozyme 3 small subunit
- Acetolactate synthase isozyme 1 small subunit
- Acetolactate synthase isozyme 3 large subunit
- Acetolactate synthase isozyme 1 large subunit
- Probable dehydratase PflD
- L
- Probable pyruvate-flavodoxin oxidoreductase
- 3-isopropylmalate dehydratase large subunit
- Probable dehydratase YbiW
- L
Sequence:
MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR
Protein: Immunoglobulin kappa variable 2D-30 (A0A075B6S6)
Organism: Homo sapiens (Human)
Function: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular location: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
Interaction partners:
Sequence:
MRLPAQLLGLLMLWVPGSSGDVVMTQSPLSLPVTLGQPASISCRSSQSLVYSDGNTYLNWFQQRPGQSPRRLIYKVSNWDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWP
Protein: Myelin basic protein (F8W3M5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Myelin membrane {ECO:0000256|ARBA:ARBA00004392}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004392}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004392}.
Interaction partners:
Sequence:
MATASTSGQNPFGLGRKKKAPGVLDQISRFFGGDKKRKGKRPHHSSTRRRGDVNPVVHFFRSFVSSPRPKSRWRELLGLASPSARGSESIRSPQRRRREQNTLSRIFNLGESRSRSPPKRWSTIF
Protein: BK channel (H8ESE5)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGEIYSPSQSKGFNQPYGYPMNCNLSRVFMEMTEEDRKCLEERKYWCFLLSSITTFCASMILVVIWRVVTHLCCQRREKEFVEPIPAPEAVQINMNGSKHAPSETDPFLKQQEEKHLGWMTEAKDWAGELISGQSLTGRFLVLLVFILSIGSLIIYFYDASFQNFQVETCIPWQDSPSQQIDLGFNIFFLVYFFIRFIAASDKVWFLLEMYSWIDFFTIPPSFVAIYLQRNWLGFRFLRALRLMTVPDILQYLNILKTSSSIRLTQLVTIFVAVCLTGAGLVHLLENSGDFFKGFINPHRITYADSVYFVLVTMSTVGYGDIYCTTLCGRLFMIFFILFGLAMFASYVPEIADLIGNRQKYGGEYKGEHGKKHIVVCGHITYDSVSHFLQDFLHEDRDDVDVEVVFLHRVVPDLELEGLFKRHFTKVEFFTGTVMDSLDLSRVKIGDADACLVLANKYSTNPDAEDAANIMRVISIKNYSSDIRVIVQLMQYHNKAYLLNIPSWDWKRGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSPHTPLWLNDYLRGAGMEMYTESLSPSFANMSFPEAANLLFNRLGLLLLAIELKDEENKECNIAINPGPHIVIQPQTQGFFIAQSADEVKRAFFWCKQCHDDIKDVSLIKKCKCKNLALFRRNTKHSTAARARATDVLQQFQPQAPAGPMGHLGQQVQLRMINQQSSTSDTHLNTKSLRFAYEIKKLMPSSGGRRNSMSIPPDGRGVDFSKDFEQQFQDMKYDSTGMFHWCPSRNLEDCVLERHQAAMTVLNGHVVVCLFADQDSPLIGLRNFIMPLRSSNFHYHELKHVVIVGDLEYLRKEWKTLYNLPKISILNGSPLSRADLRAVNINLCDMCVIISARVPNTEDTTLADKEAILASLNIKAMQFDDTLGFFPMRHQTGDRSPLGSPISMQKKGAKFGTNVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRGGYSTPETLSNRDRCRIAQISLQDNPYDGVVHNTTYGAMFTIALRRYGQLCIGLYRLHDQDNPDSMKRYVITNPPAELRIKNTDYVYVLEQFDPGLEYEPGKRHF
Protein: CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (M9PF85)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, P-body {ECO:0000256|ARBA:ARBA00004201}.
Interaction partners:
Sequence:
MSAQPSPHMNPQQQQQQQQQQQQTEQEKWINELAHPDTRETALLELSKKRETDLAPMLWNSFGTACALLQEIVNIYPSITPPTLTAHQSNRVCNALALLQCVASHPETRTAFLQAQIPLYLYPFLSTTSKTRPFEYLRLTSLGVIGALVKTDEQEVITFLLTTEIVPLCLSIMDSGSELSKTVATFIIQKILLDESGLSYICQTYERFSHVAITLGKMVIQLAKDPCARLLKHVVRCYLRLSDNTRARKALGQCLPDQLRDGTFALCLQEDKSTKQWLQMLLKNLELGATPQQIGMSPLGS
Protein: 2',3'-cyclic nucleotide 3' phosphodiesterase (K7ERC4)
Organism: Homo sapiens (Human)
Subcellular location: Melanosome {ECO:0000256|ARBA:ARBA00004223}.
Interaction partners:
Sequence:
MDEDTVATLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILVLDDTNHERERLEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSET
Protein: Ammonium transporter Rh type B (Rhesus blood group family type B glycoprotein) (Rh family type B glycoprotein) (Rh type B glycoprotein) (Q8BUX5)
Organism: Mus musculus (Mouse)
Function: Functions as a specific ammonium transporter.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27681563}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9H310}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MARVPRHRRLVLPLLCLLFQGATALLFAIFVRYNHETDAALWHWGNHSNVDNEFYFRYPSFQDVHVMVFVGFGFLMVFLQRYGFSSVGFTFLVASLTLQWATLLQGFLHSFHGGHIHVGVESLINADFCAGAVLISFGAVLGKTGPAQLLLMALLEAVLFSVNEFILLSLLGVRDAGGSMTIHTFGAYFGLFLSWVLYRSQLEKSRHRQSSVYNSDLFAMIGTIFLWVFWPSFNSAPTALGDGQHRTVVNTYYSLTASTLSTFALSALVSGDGRLDMVHVQNAALAGGVVVGTSSEMMLTPFGALAAGFLAGTVSTLGYKFFTPILESRFKLQDTCGVHNLHGMPGVLGAILGVVVAALATHEAYGDGLQSVFPLIAKGQRSATSQAVYQLFGMFVTLVFASVGGSLGGLLLRLPFLDSPPDSQCFEDQVYWEVPGEQETETQRPLRGGESDTRA
Protein: Holliday junction branch migration complex subunit RuvB (EC 3.6.4.-) (Q97SR6)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00016}.
Interaction partners:
Sequence:
MSRILDNEMMGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEAAKMRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNDLEPGDVLFIDEIHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTRAGMLSNPLRARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPRIANRLLKRVRDFAQIMGNGVIDDVITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGGPVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK
Protein: Alba DNA/RNA-binding protein (At3g04620) (F7O18.10 protein) (Q9SR12)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alba DNA/RNA-binding protein
- Transducin/WD40 repeat-like superfamily protein
- Alba DNA/RNA-binding protein
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- EEIG1/EHBP1 protein amino-terminal domain protein
- Probable receptor-like protein kinase At1g11050
- F25P12.91 protein
- At3g47680
- Transcription factor DUO1
- Arabidopsis thaliana genomic DNA, chromosome 5, P1 clone:MOK16
Sequence:
MAMEVATPAPAPIPSERNIVLAPATTTTTATVETHKKNRIQVSNTKKPLFFYVNLAKRYIQQHNEVELSALGMAITTVVTISEILKNNGLATEKKVLTSTVGMKDETKGKMVQKAKIEIVLGKSDKFDSLVPPVTNGKTPEEEASAETEASVEAQEEVAAATEV