wanglab/gogpt-training-data huggingface dataset:
Protein: Pancreas/duodenum homeobox protein 1 (Insulin promoter factor 1) (IPF-1) (Islet/duodenum homeobox 1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) (P52946)
Organism: Mus musculus (Mouse)
Function: Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:17052199}. Cytoplasm, cytosol {ECO:0000269|PubMed:17052199}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Neurogenin-3
- Hepatocyte nuclear factor 3-beta
- Insulin-2
- Insulin-1
- Transcription factor MafA
- Forkhead box protein O1
- Pancreas transcription factor 1 subunit alpha
- Hexokinase-4
Sequence:
MNSEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPPPPPPQFTSSLGSLEQGSPPDISPYEVPPLASDDPAGAHLHHHLPAQLGLAHPPPGPFPNGTEPGGLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYTAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTPSGGGGGEEPEQDCAVTSGEELLAVPPLPPPGGAVPPGVPAAVREGLLPSGLSVSPQPSSIAPLRPQEPR
Protein: DNA-directed RNA polymerase II subunit E (RPB5 homolog) (E5KT65)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ
Protein: Segmentation polarity homeobox protein engrailed (P02836)
Organism: Drosophila melanogaster (Fruit fly)
Function: This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:3935318}.
Interaction partners:
- Protein groucho
- Homeobox protein extradenticle
- Homeobox protein invected
Sequence:
MALEDRCSPQSAPSPITLQMQHLHHQQQQQQQQQQQMQHLHQLQQLQQLHQQQLAAGVFHHPAMAFDAAAAAAAAAAAAAAHAHAAALQQRLSGSGSPASCSTPASSTPLTIKEEESDSVIGDMSFHNQTHTTNEEEEAEEDDDIDVDVDDTSAGGRLPPPAHQQQSTAKPSLAFSISNILSDRFGDVQKPGKSMENQASIFRPFEASRSQTATPSAFTRVDLLEFSRQQQAAAAAATAAMMLERANFLNCFNPAAYPRIHEEIVQSRLRRSAANAVIPPPMSSKMSDANPEKSALGSLCKAVSQIGQPAAPTMTQPPLSSSASSLASPPPASNASTISSTSSVATSSSSSSSGCSSAASSLNSSPSSRLGASGSGVNASSPQPQPIPPPSAVSRDSGMESSDDTRSETGSTTTEGGKNEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEEEELEMRMNGQIP
Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 isoform X2 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 2) (E7EYW7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- Actin-like 6A
- Actin-like 6B
- Brahma protein-like protein 1
- SWI/SNF complex subunit SMARCC1 isoform X1
- SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 1b.
- SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 2.
- F-box only protein 41
Sequence:
MSSRSGFSVNPSTPINPGMNPMNPGHSSAPRMPALPLNSPYRGMSSTPNQYHQRPSMPLSRGMPMGGMGSIGSPLPGPSYSGAMPMRPGMPQSAMDPTRKRLLQQQPGGLMGPRRGVKRRKMADKVLPQRIRDLVPESQAYMDLLAFERKLDQTIARKRMEIQEAIKKPITQKRKLRIYISNTYTPGKPEGEEAEKVASWELRVEGKLLEDPGKLKRKFSSFFKSLVIELDKELYGPDNHLVEWHRMPTTQETDGFQVKRPGDVNVKCTLLLMLDHQPPQYKLDPRLARLLGVHTQTRASIMQALWLYIKNNKLQDCHEKEYINCNRYFRQIFGCPRMRFSDIPMKLASLLQHPDPIVINHIISVDPNDQKKTACFDIDVEVDDPLKAQMTGFLSSTTSQQEIATLEMKIHETIESINQLKTQRDFMLSFSNSPQEFIQDWLKSQSRDLKLMTDTVGNPEEERRTEFYHSPWVTEAVGRYIFSKVQQRRQELEQVLGIRLT
Protein: Autophagy-related protein 17 (O42651)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000269|PubMed:23950735}; Peripheral membrane protein {ECO:0000269|PubMed:23950735}.
Interaction partners:
- Autophagy protein 13
- Serine/threonine-protein kinase atg1
- Autophagy-related protein 9
- Taz1-interacting factor 1
- Putative lipase atg15
- Golgi apparatus membrane protein tvp23
- Autophagy-related protein 101
- Meiotically up-regulated gene 191 protein
- Autophagy-related protein 2
- Putative mannan endo-1,6-alpha-mannosidase C1198.07c
Sequence:
MELLQQWTQQAKAALTQARQLCGDAHKFNEDAKTDLRNSIKQHQQLKELAKLTASQCTRLDSSTALIKQLLDLVQNYPTFNQLNVLHDRLESSLKRLRDCTLDPALGSEYTNLYAFVDDTALEDLKTRLRGVTDGVWNAFEKLAGLLEEDLCANYHKRLEAVSLDFLPPAYNDTAEELADLLLQVAQHYDQCSEALNIYDTLSDAEKKDLQEVLQSDSNHVPSVLTELRSGLDQTIHYFNAVQSYKSKVDSATSILEALAEELNKNQLTNQRHEAAHELMRAQTGLEIPQLAQELVQLERHYTHFAKAYTALLQEIHRRQTYENCVRSIVDEFVGRLEKEQQAEAKCRIDFFNQYGDYLPQTLWGAVTDPPLHFEIIEHQYTELPNVKVIPDKNDKKSKQREKSSTTASKR
Protein: Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3) (Q9JJK4)
Organism: Rattus norvegicus (Rat)
Function: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:10848631}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein PEX13
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX16
- Peroxisomal membrane protein PEX14
- Similar to peroxisome biogenesis factor 26.
- ATP-binding cassette sub-family D member 3
- Peroxisome biogenesis factor 10
- Peroxisomal membrane protein 11A
- Peroxisomal targeting signal 2 receptor
Sequence:
MLRSMWNFLKRHKKKCIFLGTVLGGVYILGKYGQKKLREIQEREAAEYIAQARRQYHFESNQRTCNMTVLSMLPTLREALMQQLNSESLTALLKNRPSNKLEIWEDLKIISFTRSIVAVYSTCMLVVLLRVQLNIIGGYIYLDNATVGKNGTSILAPPDVQQQYLSSIQHLLGDGLTELVTVIKQAVQRILGSISLKHSLSLLDLEQKLKEIRTLVEQHRSCWNDKDASKSSLCHYMMPDEETPLAAQAYGLSPRDITTIKLLNETRDMLESPDFSTVLNTCLNRGFSRLLDNMAEFFRPTEQDLQHGNSINSLSSVSLPLAKIIPIVNGQIHSVCSETPSHFVQDLLMMEQVKDFAANVYEAFSTPQQLEK
Protein: Polyadenylate-binding protein RBP45 (Poly(A)-binding protein RBP45) (RNA-binding protein 45) (NplRBP45) (Q9LEB4)
Organism: Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
Function: Heterogeneous nuclear ribonucleoprotein (hnRNP)-protein binding the poly(A) tail of mRNA and probably involved in some steps of pre-mRNA maturation.
Subcellular location: Nucleus {ECO:0000269|PubMed:11105760}.
Interaction partners:
Sequence:
MMPQSGVAQPPMAPMSMDQHQYQQQAPPPTQQQQWMMPPQQPQQPQFQPQSQPAWAQQPSQQQYGAMATTNPNPSPTGNPNEVRSLWIGDLQYWMDENYLSTCFYHTGELVSAKVIRNKQTGQSEGYGFLEFRSHAAAETILQTYNGTLMPNVEQNFRMNWASLGAGERRDDSAEHTIFVGDLAADVTDYILQETFKSVYSSVRGAKVVTDRITGRSKGYGFVKFADESEQLRAMTEMNGVLCSTRPMRIGPAANKKPVGTPQKATYQNPQATQGESDPNNTTIFVGGLDPTVAEEHLRQVFSPYGELVHVKIVAGKRCGFVQFGTRASAEQALSSLNGTQLGGQSIRLSWGRSPSSKQTDQTQWGGSGGAYYGYGQGYEAYGYAPPAQDPNMYYGNYPGYANYQQPQQ
Protein: Glial fibrillary acidic protein (Q864W9)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
DETNLRLEAENNLATYRQEADEATLARLDLERKIESLEEEIRFLRKIHDEEVRELQEQLAQQQVHVEMDVTKPDLTAALREIRTQYEAVATSNMQEAEEWYRSKFADLTDAAARNAEL
Protein: Uncharacterized protein (Q4GYY0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRWPAEPGCGSQGPATPERANKLRFLLVGKTDSGNHPSGWLVARTVRYSTADAEIGPCKGLISHDCKLLLLLCGYFERNPGPLRFVQQNVNGVSAVKLSSLLALDADVYLLPEVKKLREASRICKVPPYTVYCSPPNARGGRVAILVHQRSSIQTRSVTWKALPNDTGIKAVTVKL
Protein: A disintegrin and metallopeptidase domain 30 (Q9CUC4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGGLRGVLNIDSRYYQIEPLRASSSFEHVVYLVTEDNFNNETCGVVDEETGGQTAEEEEMARISSFHQSYKHQRYLELVMVFDLDRFVFARGNMSRMVDDAILLASIADTYFQDVSLKIQLKALEVWTYYNRIRLYYPSLSEVLGQFVHYKRNSMHHRLPADWFHLYIARRYIDANAWSWGRACEEFHAGSASSFLNVNILGPATWTAHELGHCVGMIHDEEFCQCRGRKSCIMGTGRTGFSNCSYHQYFLHASYKMSYCLSDFPKLHIVERCGNKIV
Protein: Transmembrane and coiled-coil domain-containing protein 2 (Q7Z6W1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSTSSSSSWDNLLESLSLSTVWNWIQASFLGETSAPQQTSLGLLDNLAPAVQIILRISFLILLGIGIYALWKRSIQSIQKTLLFVITLYKLYKKGSHIFEALLANPEGSGLRIQDNNNLFLSLGLQEKILKKLKTVENKMKNLEGIIVAQKPATKRDCSSEPYCSCSDCQSPLSTSGFTSPI
Protein: Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42) (O35854)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:8381418, ECO:0000269|PubMed:9165094}.
Interaction partners:
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- Cystathionine gamma-lyase
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Amine oxidase
- Amine oxidase.
- Glutamate--cysteine ligase regulatory subunit
- Branched-chain-amino-acid aminotransferase, cytosolic
- Glutamate--cysteine ligase catalytic subunit
- Amine oxidase
Sequence:
MSAAILGQVWTRKLLPIPWRLCVPGRCVSSNFKAADLQVQVTREPQKKPAPSQPLLFGKTFTDHMLMVEWNSKTGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGRDKQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLFVILCPVGSYFPGDSMTPVSLLADPSFVRAWIGGVGDCKLGGNYGPTVAVQQEAQKKGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGELELATPPLDGIILPGVVRQSLLDLARTWGEFRVAERKVTMKELKRALEEGRVREVFGSGTACQVCPVHQILYEGKQLHIPTMENGPELILRFQKELKAIQYGTSAHDWMLRV
Protein: Alkyl hydroperoxide reductase Rv2159c (EC 1.11.1.-) (Alkylhydroperoxidase Rv2159c) (O06218)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Tetracyclin repressor-like C-terminal domain-containing protein
- Conserved protein
- HTH tetR-type domain-containing protein
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
- Cell division protein FtsQ
- PE-PGRS family protein PE_PGRS38
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- Phospho-N-acetylmuramoyl-pentapeptide-transferase
- UDP-N-acetylmuramoylalanine--D-glutamate ligase
- UDP-N-acetylglucosamine--N-acetylmuramyl-
Sequence:
MKFVNHIEPVAPRRAGGAVAEVYAEARREFGRLPEPLAMLSPDEGLLTAGWATLRETLLVGQVPRGRKEAVAAAVAASLRCPWCVDAHTTMLYAAGQTDTAAAILAGTAPAAGDPNAPYVAWAAGTGTPAGPPAPFGPDVAAEYLGTAVQFHFIARLVLVLLDETFLPGGPRAQQLMRRAGGLVFARKVRAEHRPGRSTRRLEPRTLPDDLAWATPSEPIATAFAALSHHLDTAPHLPPPTRQVVRRVVGSWHGEPMPMSSRWTNEHTAELPADLHAPTRLALLTGLAPHQVTDDDVAAARSLLDTDAALVGALAWAAFTAARRIGTWIGAAAEGQVSRQNPTG
Protein: Glutamate-rich protein 5 (Q6P6B1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGCSSSALNKAGDSSRFPSVTSNEHFSTAEESESCFAQPKPHALGRESTVDGNVQRESRPPLQKLKVSAEPTANGVKPLQEQPLAKDVAPGRDATDQSGSTEKTQPGEGLEESGPPQPGGKEDAPAAEGKKKDAGAGTEAESLKGNAEAQPLGPEAKGQPLQAAVEKDSLRAVEVTENPQTAAEMKPLGTTENVLTLQIAGELQPQGTVGKDEQAPLLETISKENESPEILEGSQFVETAEEQQLQATLGKEEQPQLLERIPKENVTPEVLDRSQLVEKPVMNDPFHKTPEGPGNMEQIQPEGIVGSMEHPARNVEAGAYVEMIRNIHTNEEDQRIEGETGEKVETDMENEKVSEGAETKEEETGEVVDLSAAT
Protein: RNA helicase CrhR (EC 3.6.4.13) (Q55804)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: An ATP-dependent bidirectional RNA helicase with RNA-dependent ATPase activity; does not unwind dsDNA, uses only (d)ATP. Also has ATP-dependent RNA annealing activity; concurrent annealing and helicase activity promote strand-exchange activity. In vitro has low helicase processivity, annealing processivity is probably higher. Required for correct cold adaptation, probably by aiding translation of mRNAs required for photosynthesis and electron transport. Probably regulates the cold-shock-inducible expression of the GroESL chaperones. May partially regulate its own expression at both the transcriptional and post-transcriptional level (experiments used a construct expressing a 25 kDa trunacted protein which might have dominant-negative effects); is probably not directly involved in the pathway responsible for mRNA degradation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19926653, ECO:0000269|PubMed:22368073, ECO:0000269|PubMed:23119089, ECO:0000269|PubMed:27215789}. Cell inner membrane {ECO:0000305|PubMed:27215789}; Peripheral membrane protein {ECO:0000305}. Cellular thylakoid membrane {ECO:0000269|PubMed:27215789}; Peripheral membrane protein {ECO:0000305}. Note=A small amount is localized to the cell inner membrane and the thylakoid membrane, and cosediments with polysomes. {ECO:0000269|PubMed:27215789}.
Interaction partners:
- Polyribonucleotide nucleotidyltransferase
- Bifunctional NAD
- Sll1033 protein
- Ribosome biogenesis GTPase A
- Ribosomal protein uS12 methylthiotransferase RimO
- ATP-dependent DNA helicase RecQ
- Large ribosomal subunit protein uL3
- Helicase of the snf2/rad54 family
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL24
Sequence:
MTNTLTSTFADLGLSEKRCQLLADIGFEAPTQIQTEAIPLLLSGRDMLAQSQTGTGKTAAFALPLMDRIDPEGDLQALILTPTRELAQQVAEAMKDFSHERRLFILNVYGGQSIERQIRSLERGVQIVVGTPGRVIDLIDRKKLKLETIQWVVLDEADEMLSMGFIDDVKTILRKTPPTRQTACFSATMPREIKELVNQFLNDPALVTVKQTQSTPTRIEQQLYHVPRGWSKAKALQPILEMEDPESAIIFVRTKQTAADLTSRLQEAGHSVDEYHGNLSQSQRERLVHRFRDGKIKLVVATDIAARGLDVNNLSHVVNFDLPDNAETYIHRIGRTGRAGKTGKAIALVEPIDRRLLRSIENRLKQQIEVCTIPNRSQVEAKRIEKLQEQLKEALTGERMASFLPLVRELSDEYDAQAIAAAALQMIYDQSCPHWMKSDWEVPEVDFNKPVLRRGRNAGGGQNKSGGGYQGKPGKPRRSSGGRRPAYSDRQQ
Protein: Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7) (P49582)
Organism: Mus musculus (Mouse)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q05941}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:32783947}; Multi-pass membrane protein {ECO:0000255}. Note=TMEM35A/NACHO promotes its trafficking to the cell membrane (PubMed:32783947). RIC3 promotes its trafficking to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q05941, ECO:0000269|PubMed:32783947}.
Interaction partners:
- Class E basic helix-loop-helix protein 23
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2A
- Tyrosine-protein kinase JAK2
- Secreted Ly-6/uPAR-related protein 1
- P2X purinoceptor 7
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor ionotropic, NMDA 2D
- P2X purinoceptor 2
- P2X purinoceptor 1
Sequence:
MCGRRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGTHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Protein: Microcephalin, isoform A (A1Z8Q7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTNEPSITNKLRSLLLDDQAARDRLMLKPALAVSKAISQHRSEFHQDENEAGAEGSAAKPDPPIGAATPTRQEGHWARLQQDLNSPNAALRLRAIRALKSPTKSAYNTFDVPLAEQSIITMEERNPQEPPSLPELLKDIVVYVEVRTGNDNRSEGVKSIIAKMGAQVKDRLTRTTTHVVFKDGLLSTYKKATEWNIPVVSILWIEACKVQLKICDPKQFPISNIRMYEYPELFGKMPRVKFMQPDSELNQRPRKRQGTPTSSKDNEPGSTNKRAQTGTPTTTTPKNDISRFFRAINHNKPSDDEAIESPATKLLNRISSGCYTPLPAGGTPQLMGTNGSGDAVAQKVQAQKSLQFGEQTDSNTPQAKPSSTSRPRRSTVDPPPVMTPPVRTTRRRSCVAEISSPAATDTRMTRRRSSLLTSTVIHEADPTQTAVAEPRMTRRRSSLLGIAKQAEETAQRQTIQPITEELAPVEENRNSIIMAETNIINNTNCLEQSIEITAVEAEASFKADRRGTLYASELMDISSPRRRSVAKSSLELRQENLAPRARQSLSNVTTQTSFLDVEQQVTPLFSSTRLPTGQTTGNRRRTIFNMDMDVINESIERMNQSHRMSLALANKAELGESCQVHEQEPPQAEPVPSQEPKRRRLFNPNDEVVISPAMSNRKSRLSITGSGSSSSVQKRRRSLATPAKSSSSELCATTPLSKAVTNKEAEKSKSNTEISEASLDAVPEVKKSTSNAGEENEKPKGKSRTRIRTLVHTNMHQEQINVIRKVGNTTE
Protein: Phosphatidylinositol-4-phosphate 5-kinase, putative (Q38BL1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein transport protein Sec61 gamma subunit, putative
Sequence:
MCPFPPQYPHLTVVKVCYTKALNDISVISPATHPSCSFLPALLRLNLGIEIRMLQSDVSGRAPPEEDVQWHVGEVRQPPPFYKLPGSSVTAREIGGQHSSCCCRYGGGTHSGNRMWTHSRSVSLPDSCSKMCCSSFTCCGVGATVSRHVSVHTTNANTAPHHENEEALKLRIRVLEGQLRREYQRRRSQEENFQVRLELLKSCLGTAEGAVRHKNDLFGCHRCGNNDICNTSEDCHSRDEVLEAEELDGSAPGPIRYGGLAQDTIELLDFCENIETSTAPPKIVKGHSVQRDVASPSTSEREGQTPDILFCEEGGVPQGVHMFPSLPSVTCSSADEHEVGGSANPIVEDHQLEELREVSVSCYGGEAALNNPENSRVHPYCTSLSFSTPAFGINGVGETENVSDDQKSTSCEAVNPCGSGMLALTTQLLSAGEDVSSSAYSGCSASCSETLCNPNQFGNAVDPRGSRNRAWYVHTILRDVFEKLICDHPSLKPVWEKVHKSEATLTDAFLSNPSVLKLALSEAMYLNFRCHHNKPLLETFDAPFPRQLPPFSSENTDPGLLEAFSGNSFTWSGQRQMHRTDMARVTVHAPQFFNRMRGILNLNMAELRGALTDRCVWREVPSCGESGKSLIFLGNFVLKSLKESEFYLLKESFLLKYIHYCERNCMTTLPHFYALVTFAWVSSESCEHYILTQNVFRTPHFIQRIHVAKGARVGLLSKAKSLSASWRTRFGEDVFRDDDPPPRLLTCGKLKRAQLLAQFISDTSFLASMNIVGYSCLIGMRMHNSAFTDCGYAEATSCNGEGHATGGGGGSIFDFDGGFLSEPLTAPGAEATTPWRYVCYIGLIDVLREYTSGMGLGRLTRGLFGDVQEGNEMQPSAYAEWLQGVLCNATM
Protein: Probable inactive histone-lysine N-methyltransferase SUVR1 (Protein SET DOMAIN GROUP 13) (Suppressor of variegation 3-9-related protein 1) (Su(var)3-9-related protein 1) (Q946J2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable inactive histone-lysine methyltransferase that acts as regulator of transctiptional gene silencing independently of histone H3K9 methylation. Contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9FNC7}. Chromosome {ECO:0000250|UniProtKB:Q9FNC7}.
Interaction partners:
- Putative inactive histone-lysine N-methyltransferase family member SUVH10
- Histone-lysine N-methyltransferase ATX3
- Helicase-like transcription factor CHR27
- Helicase-like transcription factor CHR28
- SNF2 domain-containing protein / helicase domain-containing protein / zinc finger protein-like protein
- Ubiquitin-ribosomal protein eL40y fusion protein
- Histone-lysine N-methyltransferase MEDEA
- Histone-lysine N-methyltransferase ATXR5
Sequence:
MAPNLRIKKACDAMKLLGISETKTRAFLRKLLKTYENNWDFIEEDAYKVLLDAIFDEADAQSTEKNKKEEEKKKKEEEKKSRSVATSRGRRKAPEPLVQDEEDDMDEDEFPLKRRLRSRRGRASSSSSSSSSYNNEDLKTQPEEEDEDDGVTELPPLKRYVRRNGERGLAMTVYNNASPSSSSRLSMEPEEVPPMVLLPAHPMETKVSEASALVILNDEPNIDHKPVISDTGNCSAPMLEMGKSNIHVQEWDWETKDILNDTTAMDVSPSSAIGESSEHKVAAASVELASSTSGEAKICLSFAPATGETTNLHLPSMEDLRRAMEEKCLKSYKIVHPEFSVLGFMKDMCSCYIDLAKNSTSQLLETETVCDMSKAGDESGAVGISMPLVVVPECEISGDGWKAISNMKDITAGEENVEIPWVNEINEKVPSRFRYMPHSFVFQDAPVIFSLSSFSDEQSCSTSCIEDCLASEMSCNCAIGVDNGFAYTLDGLLKEEFLEARISEARDQRKQVLRFCEECPLERAKKVEILEPCKGHLKRGAIKECWFKCGCTKRCGNRVVQRGMHNKLQVFFTPNGKGWGLRTLEKLPKGAFICEYIGEILTIPELYQRSFEDKPTLPVILDAHWGSEERLEGDKALCLDGMFYGNISRFLNHRCLDANLIEIPVQVETPDQHYYHLAFFTTRDIEAMEELAWDYGIDFNDNDSLMKPFDCLCGSRFCRNKKRSTKTMQILNKA
Protein: AP-1 complex subunit mu-1 (Clathrin assembly protein complex 1 mu-1 medium chain) (Mu-adaptin) (Q9HFE5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- AP-1 complex subunit sigma-1
- AP-1 complex subunit gamma-1
- AP-1 complex subunit beta-1
- AP-2 complex subunit beta
- AP-3 complex subunit sigma
- AP-2 complex subunit alpha
- AP-3 complex subunit beta
- ADP-ribosylation factor 1
- AP-2 complex subunit sigma
- Clathrin light chain
Sequence:
MASAIFVLNLKGKVIISRDYRADIPMSVVEKFLPLKSEVEEEQGFSTPCLTHEGINYIYIHHNDVYLLALSKMNSDAMEMLVFLRKMADVFIDYFKELQEESIRDNFVLVYELLDEIMDFGFPQTTETKILQEYITQTSNTVKKHAPPPIAMTNAISWRSEGIHYRKNEVFLDVIESVNLIAAADGTVIQSEILGKVRLKCYLSGMPELRLGLNDKVLFEAAGRTIKGNTVEMEDVKFHQCVRLARFENDRTISFIPPDGEFDLMSYRMSSNVRPLIWVECESIVHSGSRIEFMVKAKAQFKKRCIANNVQIIIPVPEDADSPRFQTSNGHVQYAPEQAAMVWNIKKFAGGKEFFMRAEMGLPSVKNEDIQVQKKRPVQLKFAIPYFTTSGIQVRYLKITEPKLNYHAMPWVRYVTQNGTEYSIRQ
Protein: Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) (Q9HB20)
Organism: Homo sapiens (Human)
Function: Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane. Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration. Binds preferentially to PtdIns(4)P. Negatively regulates APOB secretion from hepatocytes.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15107860}; Peripheral membrane protein {ECO:0000269|PubMed:15107860}. Note=Localizes to ER-trans Golgi network (TGN) contacts sites. {ECO:0000269|PubMed:30659099}.
Interaction partners:
- ADP-ribosylation factor 1
- Bile salt-activated lipase
- Glycolipid transfer protein
- Pleckstrin-2
- Pleckstrin
- Cyclin-dependent kinase inhibitor 2A
Sequence:
MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAKFKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHPGSCSSERSSHSIKEPVSTLHRLSQRRRRTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEESRLMAKKQSESEDTLPSFSS
Protein: Uncharacterized protein (Q57YS7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSKKQGAQGLETSPELSFIKQGHLNLLIHTKDGEQRLVPVDSLAFIDDPQLVRSRTMDQVNFNSECIFKVTLDFSEPIPCIEETAVREMTDWVLCSCKGNNAFYSPVEKRLILQSCTVCLQSNVRALVDPFVVMLLYNEEGWVVDRVLK
Protein: Syntrophin, alpha 1 (A0A8J8Y1B9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
Sequence:
MASGRRAPRTGLLELRSGAGSGAGGERWQRVLLTLAEDALTVSPADGEPGPEPEPAQLNGAAEPGAASPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQALKKTGKEVVLEVKYMKEVSPYFKNSAGGTSVGWDSPPASPLQRQPSSPGPQPRNLNEAKHVSLKMAYVSRRCTPTDPEPRYLEICAADGQDTLFLRAKDEASARSWAGAIQAQISTFIPWVKDELQALLTATGTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYCSLPQTREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTGVPACTWNGRPCNLSVHIDKGFTLWAAEPGATRAVLLRQPFEKLQMSSDDGMSLLFLDFGGAEGEIQLDLHSCPKTMVFIIHSFLSAKVTRLGLLA