wanglab/gogpt-training-data huggingface dataset:
Protein: Alpha-hydroxynitrile lyase (AtHNL) (EC 4.1.2.10) ((R)-hydroxynitrile lyase) ((R)-oxynitrilase) (Methylesterase 5) (AtMES5) (Q9LFT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cyanogenesis, the release of HCN from injured tissues (By similarity). Displays R-selective hydroxynitrile lyase activity. Also accepts nitromethane (MeNO2) as a donor in a reaction with aromatic aldehydes to yield (R)-beta-nitro alcohols.
Interaction partners:
- (R)-mandelonitrile lyase-like (Hydroxynitrile lyase-like) ((R)-oxynitrilase-like)
- Bifunctional L-3-cyanoalanine synthase/cysteine synthase C1, mitochondrial
- RNA-binding
- Uncharacterized protein At1g27050
- Probable LRR receptor-like serine/threonine-protein kinase At5g10290
- BRISC and BRCA1-A complex member 1
- tRNA
- WAT1-related protein At4g01450
- Mitochondrial glycoprotein family protein
Sequence:
MERKHHFVLVHNAYHGAWIWYKLKPLLESAGHRVTAVELAASGIDPRPIQAVETVDEYSKPLIETLKSLPENEEVILVGFSFGGINIALAADIFPAKIKVLVFLNAFLPDTTHVPSHVLDKYMEMPGGLGDCEFSSHETRNGTMSLLKMGPKFMKARLYQNCPIEDYELAKMLHRQGSFFTEDLSKKEKFSEEGYGSVQRVYVMSSEDKAIPCDFIRWMIDNFNVSKVYEIDGGDHMVMLSKPQKLFDSLSAIATDYM
Protein: Coiled-coil domain-containing protein SCD2 (Protein STOMATAL CYTOKINESIS DEFECTIVE 2) (Q8RWD5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in growth and development through its role in cytokinesis and polarized cell expansion. Required for plasma membrane internalization. May function in clathrin-mediated membrane trafficking, including plasma membrane endocytosis, essential to both cytokinesis and cell expansion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24179130}; Peripheral membrane protein {ECO:0000269|PubMed:24179130}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:24179130}. Note=Colocalized with clathrin at the plasma membrane. {ECO:0000269|PubMed:24179130}.
Interaction partners:
- DENN domain and WD repeat-containing protein SCD1
- AUGMIN subunit 5
- Exocyst complex component SEC15B
- Exocyst complex component EXO84A
- Histone H4
Sequence:
MDRRRAGSPVYGRQWSESSNSTEATSPAMSPAHRKQLGGIGGFSTVKRTQNVAAKAAAQRLAKVMALQNKDNGDEDDEDEDEDLSLRFASASLKPARHAPSSISSTGSNSSNGNNNLPAVSFAPRTRSPSPALGRNFAEQVPSSVRSASAGRPSMSARSTTPTPIPNLMPPSRVSVKTPVSIPPLDPPTRSRDKRFFADVPSVNSKEKGDQREASALRDELDMLQEENENVLEKLRRAEEKRVEAEARAKELEKQVASLGEGVSLEAKLLSRKEAALRQREAALNVAKQKKSGKDEEIVSLRSELENLKDEATTAAERLQEAESEAKSLRTMTQRMILTQDEMEEVVLKRCWLARYWGLAVQHGICADIAPSRQEHWSKLAPLPFELVTSAAQKAKELSWDKGGNDRSKAARDLSDLTGEGNIESMLSVEMGLRELASLKVEDAVVLIFAQQRKLSLVRHTVSDSKGHGESRFIDAYELGEAEQEDVAFKQAWLMYFWGRAKLHGVEDDIAEERVQLWISRSSGKSQTTSHDALDVERGLIELRKLGIEQQLWEASRREIDQLPSPTSSNHDLDADS
Protein: NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4) (A0A0G2K6D8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion matrix {ECO:0000256|HAMAP-Rule:MF_03161}.
Interaction partners:
Sequence:
MVLLGVDRMRGLIFRPTRGRWITQMSQLRSHGSTGLFVPPSPPLDHEKIKELQRFISLSKKLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHIDFIRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNWEKLGKLHWLVTQNVDALHSKAGNQRLTELHGCMHRVLCLSCGEQTARRVLQDRFQALNPSWSAEAQGVAPDGDVFLTEEQVRSFRVPCCDRCGGPLKPDVVFFGDTVNPDKVDFVHQRVKEADSLLVVGSSLQVYSGYRFILTAREKKLPIAILNIGPTRSDDLACLKLDSRCGELLPLIDPQ
Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (A0A0B4K756)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
Interaction partners:
Sequence:
MGTKTQPQLAKENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHKLPQDFAFPLGLGTKKTQVLHNNLNSADGPNSKGNNVTGHHMVNNNTNMRHNQNQNHSSMADITADGRGNGGDDGRGSGGSDDMSPRAPCQDLDTINL
Protein: Histone H2A (Q8CGP4)
Organism: Mus musculus (Mouse)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003767}.
Interaction partners:
- Histone H2B type 1-A
- Histone H4
- Histone H3.2
- Histone H3.3
- Histone H2B type 2-B
- Histone H3.1
- Histone H2B type 2-E
- Histone H3-like centromeric protein A
- Histone deacetylase 1
- Histone H2B type 1-K
Sequence:
MSGPTKRGGKARAKVKSRSSRAGLQFPVGRVHRLLRQGNYAQRIGAGAPVYLAAVLEYLTAEVLELAGNAARDNKKTRITPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHKSQTK
Protein: Leucine-rich glioma-inactivated protein 1 (B3DJS9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted {ECO:0000256|ARBA:ARBA00004613}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MGYANRSIRAYTFLLWVAAVLLFAESRRGKQPRCPSGCTCTKDNALCENVRSVPHSFPPDVISLSFVKSGFSEIAGGSFLHTPSLQLLLFTANSFDLIDEDAFQGLPHLEYLFIENNKIESISPHAFRGLKSLIHLSLAYNNLETLPRDIFKGMDALTKVDLRGNLFSCDCKLKWLVEWMFSTNATVDQLYCSGPSPYQGKKINDLMPQSFDCITAEFALKKTLAFESISVEAFSYGNDQYVVYAQPFTGRCNFMEWDHVNMEFRDHEIILSTSTVVCKPMVIDDHLFIVVAQLFGGSHIYKRDSSANKFIKIQDIDILKIRKPNDIETFRVDGEFYFVIADSSKAGSTTVYKWNGNGFYSHQSLHPWYRDTDVEYLEIAGKPHIILSSSSQWPVVYQWSRSQKQFDRRTDIPDMEDVYAVKHFKVKGELFICLTRFIGDSKVMKWDGAMFIEIQTMPSRGSMVFQPVSIGNWQYAILGSDYSLTQVYQWDAKKSQFVHFQELNVQAPRAFSLASIDNREFLLASSFKGKTQIYEHLMIDLSS
Protein: Protein misato homolog 1 (A0A3B3IUD2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MAGGAREVLTLQLGHFAGFVGAHWWNQQDAALGRATDSKEPPGELCPDVLYRTGRTLHGQETYTPRLILMDLKGSLSSLKEEGGLYRDKQLDAAIAWQGKLTTHKEELYPKNPYLQDFLSAEGVLSSDGVWRVKSIPNGKGSSPLPTATTPKPLIPTEASIRVWSDFLRVHLHPRSICMIQKYNHDGEAGRLEAFGQGESVLKEPKYQEELEDRLHFYVEECDYLQGFQILCDLHDGFSGVGAKAAELLQDEYSGRGIITWGLLPGPYHRGEAQRNIYRLLNTAFGLVHLTAHSSLVCPLSLGGSLGLRPEPPVSFPYLHYDATLPFHCSAILATALDTVTVPYRLCSSPVSMVHLADMLSFCGKKVVTAGAIIPFPLAPGQSLPDSLMQFGGATPWTPLSACGEPSGTRCFAQSVVLRGIDRACHTSHRLMVVLALFWQPAHPRDTSTLCPSCMYHWGRNLGSVFTTAAAWSHEFFPSAADSLQGGSSLPPPLLKLQSTGYGSGWFPQGSSGEHPSVWGTVFLFVPAPDPGSLGQRPHQTRLAALGQLHGCWSGAR
Protein: Virulence factor mce family protein (O07786)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVVAYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPATATASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRDSINGILRQLGPTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALTALNEGRGDFVAITRSLALFVSALYQNDQQFVALNENLAEFTDWFTKSDHDLADTVERIDDVLGTVRKFVSDNRSVLAADVNNLADATTTLVQPEPRDGLETALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFANPIQLICSAIQAGSRLGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYSEERLRPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQPFTANMLTPESLAELLGGPDIAPPPPGTNLPGPPNAYDESNPLPPPWYPQPASLPAAGATGQPGPGQ
Protein: MAM and LDL-receptor class A domain-containing protein 1 (Q5VYJ5)
Organism: Homo sapiens (Human)
Function: Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:A2AJX4}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MLFFLDRMLAFPMNETFCCLWIACVFNSTLAQQGTESFQCDNGVSLPPDSICDFTDQCGDSSDERHCLNYERCDFEDGLCHMTQDQSLQPSWTKRSGMIGLSPPFYDHNGDVSAHFLSLVSRVDSISSSLRSRVFLPTNDQHDCQITFYYFSCQVSGKLMVGLQTACGGPIQHLWQNTAALPNQWERNVIKIQSSQRFQVVFEGQMASTYEQDEVIAIDDISFSSGCLPANDGILLCQEALNAERELCHPDTDLCRFDATDEELRLCQACGFEFDMCEWTSEASAGQISWMRTKAREIPAFESTPQQDQGGDDEGYYVWVGAKHGFTLNHLDSRAYLNSSVCHCLGKSCHLQFYYAMESSVLRVRLYNNKEEEIFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRSFIALDHLWVYACGQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLTCDFESGFCGWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEAQRSPGVAKLGSPVLTKLLTASTPCQVQFWYHLSQHSNLSVFTRTSLDGNLQKQGKIIRFSESQWSHAKIDLIAEAGESTLPFQLILEATVLSSNATVALDDISVSQECEISYKSLPRTSTQSKFSKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRSQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTDENECGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRPPKDHTLGNENGHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFVSAKATGSIQILIKTEKGLSKVWQESKQNPGNHWQKADILLGKLRNFEVIFQGIRTRDLGGGAAIDDIEFKNCTTVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSECPLNYCRNGGTCVVEKNGPMCRCRQGWKGNRCHIKFNPPATDFTYAQNNTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCAFVNPVYGNWSNPEKTESSVYSFSNPLYGTTSGSLETLSHHLK
Protein: 9-cis-epoxycarotenoid dioxygenase NCED2, chloroplastic (AtNCED2) (EC 1.13.11.51) (O49505)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity. Catalyzes the first step of abscisic-acid biosynthesis from carotenoids.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:12834401}. Note=Partially bound to the thylakoid.
Interaction partners:
- Xanthoxin dehydrogenase
- Zeaxanthin epoxidase, chloroplastic
- Abscisic-aldehyde oxidase
- Phytoene synthase 1, chloroplastic
- 15-cis-zeta-carotene isomerase, chloroplastic
- Zeta-carotene desaturase, chloroplastic/chromoplastic
- Abscisic acid 8'-hydroxylase 1
- Prolycopene isomerase, chloroplastic
- Lycopene beta cyclase, chloroplastic
- Molybdenum cofactor sulfurase
Sequence:
MVSLLTMPMSGGIKTWPQAQIDLGFRPIKRQPKVIKCTVQIDVTELTKKRQLFTPRTTATPPQHNPLRLNIFQKAAAIAIDAAERALISHEQDSPLPKTADPRVQIAGNYSPVPESSVRRNLTVEGTIPDCIDGVYIRNGANPMFEPTAGHHLFDGDGMVHAVKITNGSASYACRFTKTERLVQEKRLGRPVFPKAIGELHGHSGIARLMLFYARGLCGLINNQNGVGVANAGLVYFNNRLLAMSEDDLPYQLKITQTGDLQTVGRYDFDGQLKSAMIAHPKLDPVTKELHALSYDVVKKPYLKYFRFSPDGVKSPELEIPLETPTMIHDFAITENFVVIPDQQVVFKLGEMISGKSPVVFDGEKVSRLGIMPKDATEASQIIWVNSPETFCFHLWNAWESPETEEIVVIGSCMSPADSIFNERDESLRSVLSEIRINLRTRKTTRRSLLVNEDVNLEIGMVNRNRLGRKTRFAFLAIAYPWPKVSGFAKVDLCTGEMKKYIYGGEKYGGEPFFLPGNSGNGEENEDDGYIFCHVHDEETKTSELQIINAVNLKLEATIKLPSRVPYGFHGTFVDSNELVDQL
Protein: Nucleobindin 2b (Nucleobindin-2b precursor) (Q7ZUS2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MWRPSHCCLILALWACLDALPVAVDKTKVSPPAEAQEPPENADTGLHYDRYLREVIDFLEKDPHFREKLHNTDMEDIKQGKLAKELDFVSHNVRTKLDELKRQEVNRLRTLIKAKQDLNGEKGMTVDHQALLKQFEHLNHMNPHTFEVEDLDRLIKSATNDLENFDKERHEEFKRYEMMKEHERREHLKTMNEEERKKEEEHYEEMKKKHADHPKLNHPGSQDQLKEVWEEADGLDPNDFDPKTFFNLHDTNGDGYFDEQELEALFTKELEKIYDPAQEEDDMVEMEEERLRMREHVMNEVDTNKDRLVSLEEFITATNKKEFLEPDEWETLDQNPVYTEEELREFEQHLAREEQDLNLRTNDLQKQREELERQQDQLNAQKMELQQAVQHMERLKSQKTEPPVQPKALSAVEILPGDGQQLSQDLPAHS
Protein: Low-molecular weight cobalt-containing nitrile hydratase subunit beta (L-NHase) (L-nitrilase) (EC 4.2.1.84) (P29379)
Organism: Rhodococcus rhodochrous
Function: NHase catalyzes the hydration of various nitrile compounds to the corresponding amides.
Interaction partners:
Sequence:
MDGIHDLGGRAGLGPIKPESDEPVFHSDWERSVLTMFPAMALAGAFNLDQFRGAMEQIPPHDYLTSQYYEHWMHAMIHHGIEAGIFDSDELDRRTQYYMDHPDDTTPTRQDPQLVETISQLITHGADYRRPTDTEAAFAVGDKVIVRSDASPNTHTRRAGYVRGRVGEVVATHGAYVFPDTNALGAGESPEHLYTVRFSATELWGEPAAPNVVNHIDVFEPYLLPA
Protein: RNA exonuclease 1 (EC 3.1.-.-) (RNase H(70)) (P53331)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: 3' exoribonuclease required for 5S rRNA maturation and for the proper maturation of the 5' cistron of the tRNA-Arg3 dicistronic gene. Involved with REX2 in the maturation of the 5.8S rRNA, and with REX2 and REX3, in the 3' processing of the U5L snRNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:10359084}.
Interaction partners:
- Oligoribonuclease, mitochondrial
- RNA exonuclease 3
- Exosome complex exonuclease RRP6
- Uncharacterized protein YGR273C
- La protein homolog
- Exosome complex protein LRP1
- RNA exonuclease NGL2
- Proliferating cell nuclear antigen
- Ribonuclease Z
- PAN2-PAN3 deadenylation complex subunit PAN3
Sequence:
MQVEGPDTNFVSDLALGSKKRRLSKTSVQEDDHTNVVSEVNKNKKKKKAKPMTCTLLKSVVEKGIGIKDVRDMTQYLLQAENNSPKWIDICNRSSLQKMIVLFIPGLQPDDFENGKNTFNEISDDNFKYIPGEIASTFHTFPVMAPGSKMTLFSPYNSFINVGLSKMEKINKLKELQKKKKITINDLVLSEQQLVANDYPLDSGDTNFDTDWVQTVDFTHGGSHIFALDCEMCLSEQGLVLTRISLVNFDNEVIYEELVKPDVPIVDYLTRYSGITEEKLTVGAKKTLREVQKDLLKIISRSDILIGHSLQNDLKVMKLKHPLVVDTAIIYHHKAGDPFKPSLKYLSETFLNKSIQNGEHDSVEDARACLELTKLKILNGLAFGIGINTENLFTKLHRFEVKTVLLNDMIIKNHTEDDSKGQLIRCVEDDETWTHIHENLNKDVKLIVGRIKNLERSRNYNKKPRKETPSFDASMVLHDIGQHLTQLYENATPGTMILIMSGTGDTRPWNNLSTELEFIQDKKERLDKRREREPEIVEAIKLARGGVASFTVK
Protein: Villin-3 (O81645)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds actin and actin filament bundles in a Ca(2+)-insensitive manner, but severs actin filaments in a calcium-dependent manner, regardless of the presence or not of VLN1 (AC O81643). Acts redundantly with VLN2 (AC O81644) to generate thick actin filament bundles, to regulate directional organ growth and in sclerenchyma development.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10631247, ECO:0000269|PubMed:22209875}.
Interaction partners:
- T-complex protein 1 subunit zeta 2
- Vacuolar protein sorting-associated protein 53 B
- Ribosome biogenesis protein NSA2 homolog
- Actin-depolymerizing factor 4
- Beta-adaptin-like protein C
- Stomatal closure-related actin-binding protein 1
- Conserved oligomeric Golgi complex subunit 6
- Probable ADP-ribosylation factor GTPase-activating protein AGD6
- Tubulin gamma-1 chain
- Conserved oligomeric Golgi complex subunit 4
Sequence:
MSGSTKVLDPAFQGVGQKPGTEIWRIENFEPVPVPKSEHGKFYMGDTYIVLQTTQNKGGAYLFDIHFWIGKDTSQDEAGTAAVKTVELDAALGGRAVQYREIQGHESDKFLSYFKPCIIPLEGGVASGFKKPEEEEFETRLYTCKGKRAVHLKQVPFARSSLNHDDVFILDTKEKIYQFNGANSNIQERAKALVVIQYLKDKFHEGTSDVAIVDDGKLDTESDSGEFWVLFGGFAPIARKVASEDEIIPETTPPKLYSIADGQVESIDGDLSKSMLENNKCYLLDCGSEIFIWVGRVTQVEERKTAIQAAEDFVASENRPKATRITRVIQGYEPHSFKSNFDSWPSGSATPANEEGRGKVAALLKQQGVGLKGLSKSTPVNEDIPPLLEGGGKLEVWYIDANSKTVLSKDHVGKLYSGDCYLVLYTYHSGERKEDYFLCCWFGKNSNQEDQETAVRLASTMTNSLKGRPVQARIFEGKEPPQFVALFQHMVVLKGGLSSGYKNSMTEKGSSGETYTPESIALIQVSGTGVHNNKALQVEAVATSLNSYDCFLLQSGTSMFLWVGNHSTHEQQELAAKVAEFLKPGTTIKHAKEGTESSSFWFALGGKQNFTSKKVSSETVRDPHLFSFSFNRGKFQVEEIHNFDQDDLLTEEMHLLDTHAEVFVWVGQCVDPKEKQTAFEIGQRYINLAGSLEGLSPKVPLYKITEGNEPCFFTTYFSWDSTKATVQGNSYQKKAALLLGTHHVVEDQSSSGNQGPRQRAAALAALTSAFNSSSGRTSSPSRDRSNGSQGGPRQRAEALAALTSAFNSSPSSKSPPRRSGLTSQASQRAAAVAALSQVLTAEKKKSPDTSPSAEAKDEKAFSEVEATEEATEAKEEEEVSPAAEASAEEAKPKQDDSEVETTGVTFTYERLQAKSEKPVTGIDFKRREAYLSEVEFKTVFGMEKESFYKLPGWKQDLLKKKFNLF
Protein: N-glycosylase/DNA lyase OGG1 [Includes: 8-oxoguanine DNA glycosylase 1 (AtOGG1) (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] (Q9FNY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in repair of DNA damaged by oxidation by incising DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (Fapy) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Subcellular location: Nucleus {ECO:0000269|PubMed:22473985}.
Interaction partners:
- DNA-repair protein XRCC1
- Endonuclease III homolog 1, chloroplastic
- DNA-
- DNA polymerase eta
- Adenine DNA glycosylase
- DNA ligase 1
- Flap endonuclease 1
- DNA-
- Polynucleotide 3'-phosphatase ZDP
- DNA-
Sequence:
MKRPRPTSQPSISSTVKPPLSPPVTPILKQKLHRTGTPKWFPLKLTHTELTLPLTFPTGQTFRWKKTGAIQYSGTIGPHLVSLRQRPGDDAVSYCVHCSTSPKSAELALLDFLNAEISLAELWSDFSKKDPRFGELARHLRGARVLRQDPLECLIQFLCSSNNNIARITKMVDFVSSLGLHLGDIDGFEFHQFPSLDRLSRVSEEEFRKAGFGYRAKYITGTVNALQAKPGGGNEWLLSLRKVELQEAVAALCTLPGVGPKVAACIALFSLDQHSAIPVDTHVWQIATNYLLPDLAGAKLTPKLHGRVAEAFVSKYGEYAGWAQTLLFIAELPAQKTLLQSFSQPINKLDESAEVNETSCDTLKP
Protein: Metal homeostatis protein BSD2 (Bypass SOD defects protein 2) (P38356)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for homeostasis of heavy metal ions such as cadmium, cobalt and copper. Controls metal ion transport and prevents metal hyperaccumulation by negatively regulating the SMF1 and SMF2 metal transport systems. Under manganese-replete conditions facilitates trafficking of SMF1 and SMF2 metal transporters to the vacuole where they are degraded.
Subcellular location: Endoplasmic reticulum. Vacuole. Membrane; Multi-pass membrane protein.
Interaction partners:
- E3 ubiquitin-protein ligase RSP5
- Manganese transporter SMF1
- Uncharacterized protein TRE1
- Manganese transporter SMF2
- Metal homeostasis factor ATX2
- Protein SSH4
- Superoxide dismutase
- Ubiquitin ligase-binding protein BUL1
- Transmembrane E3 ubiquitin-protein ligase 1
- Transketolase 1
Sequence:
MPEQELLIGQEMNTLHAGSSTDGINVGNAGRTRDTQTGVEGETEIGSDEEDSIEDEGSSSGGNSTTERLVPHQLREQAARHIGKIGRHFNILDRLFKKRTQQSSDIQQGAMFDGVFSNLSAKPDTTETEGNNEQDIPPTYDEAAADMAPSYYGMDLNNSDIYYDEICIEGLPVGNIANLLWNIIVSTSFQFIGFLITYILHTSHAAKQGSRFGLGLTFIGYGYSMIPNDVTSKVGKNKSLNRMELEDPNEFDDVRLNSQSTTQDKFESHLNHGLDEEKQNIPWLAVFVAFLGLFITLKSIYDYIQVKKLEKKYLNQSQNQA
Protein: Lipocalin-15 (Q6UWW0)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MMSFLLGAILTLLWAPTAQAEVLLQPDFNAEKFSGLWYVVSMASDCRVFLGKKDHLSMSTRAIRPTEEGGLHVHMEFPGADGCNQVDAEYLKVGSEGHFRVPALGYLDVRIVDTDYSSFAVLYIYKELEGALSTMVQLYSRTQDVSPQALKSFQDFYPTLGLPKDMMVMLPQSDACNPESKEAP
Protein: BPI fold containing family B member 4 (A0A669KBJ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWMAWCVAALSVVAVCGTSHETNTVLRVTKDVLSNAISGMLQQSDALHSALREVPLGKARGDGGGPLLGGLLGGSGSGGGGGGGLLGGLLGGGGGGGGSDLLGGGLLGGSGSSGGELLGGGGGSGGGLLGGSGGGLLGGSGGGLLGGSRGGLLGGSGGGLLGGGRHHYNDYRRIEFPRGVGDIPYNDFHVRGPPPVYTNGKKLDGIYQYGHIETNDNTAQLGGKYRYGEILESEGSIRDLRNSGYRSAENAYGGHRGLGRYRAAPVGRLHRRELQPGEIPPGVATGAVGPGGLLGTGGMLAADGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGKSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLADVLPDLLCPIVDVVLGLVNDQLGLVDSLIPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGGLIDYPLGWPAVSPKPMPELPPMGDNTKSQLAMSANFLGSVLTLLQKQHALDLDITNGMFEELPPLTTATLGALIPKVFQQYPESCPLIIRIQVLNPPSVMLQKDKALVKVLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEVLVEKIFDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA
Protein: Frizzled 8b protein (Frizzled class receptor 8b) (Frizzled homolog 8b) (Frizzled-8b precursor) (Q9PWK6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDSPTQGTHWSALALCVLLLWSSVCGREHVCQEISVPLCRGIGYNYTYMPNQFNHDNQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGDPNTLCMDYNRTDATSSPAAPKTTSRPGKPFKRKNKSSPGSSSCEPECYCRAPMVPVHSDHHPLYNRVKTGQIPNCAMPCHNPYLSQEERTFATFWIGIWSVLCFLSTFATVATFLIDIERFKYPERPIIFLSACYMFVSLGYIIRLIAGHERVACNQNHEVDHIHYETTGPALCTLVFLLIYFFGMASAIWWVILSFTWFLAAGLKWGNEAIARYSQYFHMAAWLIPSVKSITVLALSSVDGDSIAGICYVGNQNLDNLRGFVLAPLVIYLFIGTIFLFAGFVSMFRIRSVIKQGGTKTDKLERLMVRIGVFTVLYTVVAIMIVACYVYEHHNREAWEIAHACNCSSDKKAPKPDYAVFMLKYFMCLLIGITSGAWTWSSKTLDSWRALCTRCCCCRWATKGTSGSVYSDASSGLTWRSGTASSVLCPPKQMPLSRV
Protein: RNA polymerase sigma-B factor (Q9K5J6)
Organism: Bacillus anthracis
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Interaction partners:
- Serine-protein kinase RsbW
- Anti-sigma factor antagonist
- Conserved hypothetical protein
- General stress protein
- Bacterioferritin
- Methyltransferase
- DUF4028 domain-containing protein
- Catalase
- Type 1 glutamine amidotransferase
- Circadian input-output histidine kinase CikA
Sequence:
MEIQSQPTNLTKEDVIKLIAEFQQNQCGEAQERLVDHYKNLVYSIAYRYSKGGPMHEDIIQVGMLGLLGAIRRYDYSIGNAFEPFAIPTIVGEIKKYLRDKTWGIHVPRRIKDLGGKIKLAIEELTDHLQRSPKIIEIADHLGLSEEEVLEIMDAKNNYRVSSLDDVVENASDGSSVARIESVGEVEQGYEQTERRLVLKDIFNVLNETEKSVIHYIFEENLNQKDTGERLGISQMHVSRIKRQAISKLKQAAFLDT
Protein: Probable methyltransferase PMT18 (EC 2.1.1.-) (Q9C884)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- COBRA-like protein 8
- RING-type E3 ubiquitin transferase
- 3-oxo-5-alpha-steroid 4-dehydrogenase
- Phospholipid-transporting ATPase 1
- Protein YIP
Sequence:
MAKENSSHSLAEAKRKRLTWILCVSGLCILSYVLGSWQTNTVPTSSSEAYSRMGCDETSTTTRAQTTQTQTNPSSDDTSSSLSSSEPVELDFESHHKLELKITNQTVKYFEPCDMSLSEYTPCEDRERGRRFDRNMMKYRERHCPSKDELLYCLIPPPPNYKIPFKWPQSRDYAWYDNIPHKELSIEKAIQNWIQVEGERFRFPGGGTMFPRGADAYIDDIARLIPLTDGAIRTAIDTGCGVASFGAYLLKRDIVAMSFAPRDTHEAQVQFALERGVPAIIGIMGSRRLPYPARAFDLAHCSRCLIPWFQNDGLYLTEVDRVLRPGGYWILSGPPINWKKYWKGWERSQEDLKQEQDSIEDAARSLCWKKVTEKGDLSIWQKPINHVECNKLKRVHKTPPLCSKSDLPDFAWYKDLESCVTPLPEANSSDEFAGGALEDWPNRAFAVPPRIIGGTIPDINAEKFREDNEVWKERISYYKQIMPELSRGRFRNIMDMNAYLGGFAAAMMKYPSWVMNVVPVDAEKQTLGVIFERGFIGTYQDWCEGFSTYPRTYDLIHAGGLFSIYENRCDVTLILLEMDRILRPEGTVVFRDTVEMLTKIQSITNGMRWKSRILDHERGPFNPEKILLAVKSYWTGPSS
Protein: SD12984p (Q8MRY5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNVMRKLRGAASAGSVSGSSSGTSTANNSSPGSSRNGTDAGAPTAANGRNAEEALMDARVQVSLTTLKKLFNEYTHPREPLSEQERDDKLYEMLPLFCKVFSSCPSNDMSEKFWDVVAFCQQVSRLMVSEIRKRASNQSTEAASIAIVKFLEVETTEETSSGWMLLATLNLLANGDVSLIQVMTAAAVPSTLVKCLYLFFDLPIVEDDEPSADGGAVSEFNAHERRTLLQKVFVQLLVKLCSYPYPAEELARMDDLTLLFSAITSPCPIHNIVWRKNAAEILTTISRNGLTDAVVSYIHSKGCMALCVDNMQRLTFGNPLEIVEMFVTVFCFLKDSSQVSQILMDDFRASQGYVKKCHEMPMNAFPRGLTHGKTGDFAANN