wanglab/gogpt-training-data huggingface dataset:
Protein: N5-carboxyaminoimidazole ribonucleotide synthase (N5-CAIR synthase) (EC 6.3.4.18) (5-(carboxyamino)imidazole ribonucleotide synthetase) (P9WHL9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Interaction partners:
- N5-carboxyaminoimidazole ribonucleotide mutase
- Phosphoribosylformylglycinamidine cyclo-ligase
- Amidophosphoribosyltransferase
- Bifunctional purine biosynthesis protein PurH
- Adenylosuccinate lyase
- Phosphoribosylformylglycinamidine synthase subunit PurL
- Phosphoribosylamine--glycine ligase
- Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Phosphoribosylformylglycinamidine synthase subunit PurQ
- Phosphoribosylglycinamide formyltransferase
Sequence:
MMAVASSRTPAVTSFIAPLVAMVGGGQLARMTHQAAIALGQNLRVLVTSADDPAAQVTPNVVIGSHTDLAALRRVAAGADVLTFDHEHVPNELLEKLVADGVNVAPSPQALVHAQDKLVMRQRLAAAGVAVPRYAGIKDPDEIDVFAARVDAPIVVKAVRGGYDGRGVRMARDVADARDFARECLADGVAVLVEERVDLRRELSALVARSPFGQGAAWPVVQTVQRDGTCVLVIAPAPALPDDLATAAQRLALQLADELGVVGVLAVELFETTDGALLVNELAMRPHNSGHWTIDGARTSQFEQHLRAVLDYPLGDSDAVVPVTVMANVLGAAQPPAMSVDERLHHLFARMPDARVHLYGKAERPGRKVGHINFLGSDVAQLCERAELAAHWLSHGRWTDGWDPHRASDDAVGVPPACGGRSDEEERRL
Protein: LD17611p (U3 small nuclear riboprotein factor 55K) (Q8MSW9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Lethal
- RE67794p
- Nucleolar protein 56
- LD10780p
- U3 small nucleolar RNA-associated protein 15 homolog
- LD41718p
- Nucleolar protein 58
- Nucleolar protein 6
- LD47749p
- FI08810p
Sequence:
MSSSFFLKPGAKGTKKRKNPAATTKGKPLKKGGKPGKSTPAAGGPVPKKQRRPKEEDEEIASDDEEYNSDLGGDDNTLAFSSDEGEEETPQDKRLRLAKQYLSEIEKQEAERAEDRELAQSVEQRLQTEYLDSVGKLRRNIAGSLKACESSRILKHKLHHTPICALALSPDGKFLYTGAKSQFLLKWCTETGKVLEKSDVLSHREEPETGKKRRSHVISICLSSDMKYLALAEGGPHIQIWCPQTMKHIKTLKGHRDSVAGLVFRKGTHDLYSAAKDRSVKIWSLDEMAYVESLFGHQTAVTSIDALSRERAITAGGSDCSLRIWKITEESQLIYNGHKDSIECVKYINDEHFVSGGMDGAIGLWSALKKKPICTTQLAHGVGENGVANWITAIAVVVNTDLVATGSCDGCVRLWQTNPNARKMNLIQSISIAGFINGLAFNADGSKLFVATGQEHRLGRWWRLKEAKNQVVVLDVKLQSAASS
Protein: ATP-dependent DNA helicase PIF2 (EC 3.6.4.12) (DNA repair and recombination helicase PIF2) (Q384Y0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Essential for replication of kinetoplast maxicircles, but not minicircles.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19646907}. Note=Localizes throughout the tubular structure of the single mitochondrion.
Interaction partners:
- TFIIH basal transcription factor complex helicase/translocase XPB subunit
Sequence:
MSSKTVVWSSLGRFMRTSHHRLLDEKLFPASHNRHVQSRLLSTPLSLIAVPSWMSKCRTSAVRLSRHPPQVSGQEPCAVTASSSVGTWHGSSPAGLRRCQHVRSLNGWTTPGDVPIRHGSRSIATIATGCGGVGAGGINSSVDVAEVSGVSTSGVAAAPTVALPPGPPVEKPPLICVVRRATRGGAAADSVGTGTPGKCDKPPDSSNTLVGTIARVLSSSGECGRHSNANQEGYSLGSRPARKILVKLEADTVAAPLADTKEKQIYVQQQPVVVAQSPLARSSSTVTWEEGDTLVYNIFTQRVVKSSSASIRALSVLGVGVRSSEKELSVVDPHALVEFRDKLREKEVSWPSAWRSSLFNQLQHVLLKDQPMEEMISRVHELLQLHYQRVKRSCVANVTKGEPDTKTEEANPAGDEVAINGEMTYHERLLGYPDLNEEQRRVVDFVLRGYNTYIGGGAGTGKSLLLRVIRQELVSRGLTVATTATTGIAARRLNGATLHHCFGVNVYGEFTRRAELKEFDVIIIDEVSMLSKELFESLEFQLRRANGVDLPFGGVQVILSGDFLQLGAICSVSLVHSSVFRRNFAMLKLQRVVRQEGSSIFAQQLQELRRGTVPHDLQDTVQFLSPPETAKWLEGEGKGAVKLLPTNKEVDEVNQAELDKLPSDLVVYPAQMQAPSLVGRWTATYILEAVVKDTKMIDTHKLTRALEQYVLDFLQKTPYASDYTLPVVGQRYIVLYKLFVDAFAFRVRIPQDMSEKDMRDLALHLRGLETWLPACGLGVFLREILDSPDGLHTDADDYTLTRYAELHPMASPLRLKKGAKVMLRTNLAPGLVNGSLGVVVGFKELSAKHLPRFVNTPGRIAAVENYAEYLRYEHGFTTAFAPEVDFGGGRVIVVPPVLFSVGGLSNTNHYHVGIVSLPLSLAYAFTVHKVQGLTLAGRVHLELSRMWPCDHLLYVAMSRVRNPEQLTVSSFHNSLVRCASECLLFDDSLPPVEQVRVLPHFFQASWQRTPSRRKAALQRKREQAKQSKQKKAAKLKEAMIKQAKEATP
Protein: Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Q7ZV92)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
- Aquarius intron-binding spliceosomal factor.
- Pre-mRNA-splicing factor SPF27
- Crooked neck-like protein 1
- Cell division cycle 5-like protein
- Pre-mRNA-splicing factor SYF1
- Pleiotropic regulator 1.
- Pre-mRNA-splicing factor ISY1 homolog
- Peptidyl-prolyl cis-trans isomerase E
- Protein CWC15 homolog
- Pre-mRNA-splicing factor CWC22 homolog
Sequence:
MSLVCAISNEVPEHPCVSPVSNQVFERRLIEKYIAENGADPINGQPLSEEQLIDIKVSHPIRPKAPSATSIPAILKSLQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAAREALATLKPQAGLVAPQAAPASQPAAVGAGGEAMEVSEQVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVRAEDLSKYRQVGSHAGLHSASVPGILSLDLCPTDTNKVLTGGADKNVVVFDRREEQIVATLKGHTKKVSSVIYHPAQAVVFSASSDSTIRVWSVTGGNCVQVVRAHESAVTGLSLHATGDYLLSSSEDQYWAFSDIQTGRVLTKVTDETAGCALTCAQFHPDGLIFGTGTGDSQIKIWDLKERTNVANFPGHSGPVTAIAFSENGYYLATGAQDSSLKLWDLRKLKNFKTITLDNNYEVKSLVFDQSGTYLAVGGSDIRVYICKQWSEVLNFSDHSGLVTGVAFGEHAQFLASTGMDRSLKFYSL
Protein: Adducin 3 (gamma) a (Q1LUP2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
Interaction partners:
Sequence:
MSGEPRQEVVTTPPPPSVGKREGYFDRVNENDPEYLRARNMSPDLRQDFNMMEQKKRVTQILQSPAFKDELEGMIQEQMNKGNNPTGLLALRQIADFFMSSSVAGFSTSPLSLGMVTPINDMFSVESSTMVKGEKQTRCKLASLYRIVDLFSWAHFASCYITVRVSKEQDHILIIPRGLSFAEASASNLVKVNILGDVIDQGSTNLRIDAAGFSPHAAIYSIRPDVRCIVHISTPATAAVSSMKCGLLPISQEALILGDIAYYNYQGSLDEQEERVELQKALGPTAKVLVLRNHGIVALGETIEEAFHYIYGAQYACEIQVNAFSCAGGMENLIVLDLEKFKARTQGVAQVGVNMGSQQKWRLGELEFESLMRMLDNLGYRTGYTYRHPIVREKPRHKSEVEIPATVTAFMFDEDDAPRFPLKLLQQRQQREKTRWLNSPNCYMKVNVADGASEENRRTKTTWMKSDDGGNASGTPIRIEDPNQFVPLNTNPSEVLQKRNKIREQNRFDVMTAGPQSQKLAGIVVERPPPYMGNDEEETGALPPNPFSELNEKEEHQRRLRIDENHTGVMLNGKDDHGDEDELIKRVSQLTTSLESMEISVRSGEKIEEALTPESSPSKSPNKKKKKFRTPSFLKKNKKKEKVEA
Protein: acyl-homoserine-lactone synthase (EC 2.3.1.184) (Q5E614)
Organism: Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Interaction partners:
- histidine kinase
- Acyl-homoserine-lactone synthase
- S-adenosylmethionine synthase
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- Nucleoside phosphorylase domain-containing protein
- Quorum sensing transcriptional regulator LitR
- S-ribosylhomocysteine lyase
- Transcriptional activator protein LuxR
- Autoinducer phosphorelay protein LuxU
- Autoinducer repressor protein LuxO
Sequence:
MYDYCSQTQNFNLLQQLINARERIILNKFEGGTIGNLEYLFSTSEAAEILGKQPCSSLPKVYFHIEQMAIKVFGCLLKCSTEFEMFKLIHKPISVLHRHLDVTKKNSTSAIIDEKYHYELVQDISTDERYFHTEFSEHPLPLSDAIVLINIATFIKEHKWYEMLNHLEISSKGEHFILYQYTDNNIYPTIISSALIQTTSNKHDWLFFDTFFQNTKWKPNLNADGLLSLSHATFMSPLARSHFVDKSSTEIENDLFYSILDKTKACEAIRLTISGEKSKANYHLYLAQKGLAMALKESGRDIVFTIIEKPAMVLFYQSMNLLTPTQSPYVFTSEQDVNKSGIITYKGIWLLKNASSAFNQYSFKAYNANIISLRKKLRNQ
Protein: Nuclear receptor coactivator 4 (NCoA-4) (Ferritin cargo receptor NCOA4) (Q802X2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q5FWP7}. Chromosome {ECO:0000250|UniProtKB:Q5FWP7}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q13772}. Autolysosome {ECO:0000250|UniProtKB:Q13772}.
Interaction partners:
Sequence:
MSPMGQREKAALRQCIQARAQLDEAIADIIKAEVQLKSNSREVKSQLHSCISRHLEILRSREVWLLEQIDLVEQLKGETLHQQLQQLHSLKGQFDLLIHQLEYSGSNSLTTQLTDCLEKLSSLNLTPEETPEMSFQADAHTLRKAITSFGTIASEQMETSESFARPWLLQDCPVFFKKQKLDPERTTPLTEWLLGNHPVCSAPVKYHFSTNPHDWLLVSKESQEEKQLPAFDFQKAWGQLHDLESWLLKEKLPIRKRTCSSSSTFSIEMIDESDFNLDDVEDEQEKASDTFEKEELNKWLVNSSLVKPNQTNPDAERFKQIFKPFYESFSSSDWLSKSDCGSCCATRTTAVEIENLGKLKCLKTPPPSTPVTTPDPMEMWLHKTIPLESTCKANETCTSYAQCVCEDNCGKEALSAWLLKKEGRDKNGVPVNKNSTSKASSHQQEQQQKVQAILEAWLHPSNSAKSPDLTSLSAWAIPHIKLADPENSVENPLQAENWLHPAIKQISSATEMPNKAESKSAKDQDGKDNVEEDKWLLRKRVSAQERLGLPIVCDLFSCMKLGGDKEKWLHQAATQI
Protein: Shavenoid, isoform B (B7YZF2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform B
- Transcriptional regulator ovo
Sequence:
MRLQSLPLLLLLAVVTLPPATPTSAARPLTHPRARNHYPSEDLAEEPLMPASLLLEELQQTNGQLVNLTRQHDGDTFHTSGLSSACNADTCIGLSSGTASLVRSTGDGSGQGNEKIHQSIDGLNPATSSLGGGQMELLTRRLKLQKGRGQVANIDASGETGCTCRCLPYQRAYREDLGICVDDIHECSLSPFVSGSSSEKIPFVFLPLKGQIIYPSREISFASIHTPVCAVTGAQYLGSNGWSDLRNPIDTDYPFRMFRDEGRSFLLWLGEADLRQKMQGRLIVVHLVCRDMTVALNASNHVKGEPLMPPRNVHSPCVAFRVNGSPVKYAHNVPEVFFQPANSTTLASTSDGMTMREYVVIGICSLLLGLIYVASVFLYLYMKKRKRHSSRHSLDNLTNDINYPKNDQVTYGAPFSRVGSIYSSNSMGLGNGNESNTRTSIGSLKEDMGIVKNNPLLQHFPQLSEREHNSGFASDISNSNSECEMEEKIKTSVLVHPQLSKSPKPSGGTDNAAMDVDDFLQDNECLPAENVAVIDELMSEEKLENLRAMVSGNVRKKLYFNPAYFEPHLLAEPPQAAIEFLQKIREVIAIAKYKMASKRYQPSLNIIPEEQHPESSSSSPMFNIPLQQSLAGKGMGDKRNSIEQWLQSVPNSDATPAPKTLDRPAPPTAKKPSSGSPNKGSLRKEISAPKERPPPPPMQKSKADEGNAKSSSPAPSGPHSSRSTGKSSPEQSPKPKTNVGSTYEGFSAFSVAANVYGFAETGGEIYNNPKFMLADSPAASLRSASSRSKSMKKRSEVLDQFAAANSTPTSLTSFDRQHYNMLRNMKAPEVIYDSLKREFAAHIPTPDYDSTIEKRIKDIYSSTQSSIPSVPTPDYSSLSRKSLKQFQPDSPIYRRKSPQYLIVDYETDSLERLEPSKRKSSHSSSSPSSDVSSQLSPSLSTALPLEEEMEISHTVYDRMNGFRKEGEMKKRLAAKHQHPHPGQQQRQKEAAARIKYDTPFRGSMTIEVEHEPPSDLERTDSDQFEPDTLDRKPKKQSFCDISAWDGHKPIDSDFSQISSLPDLSRQISPAPNQGIKPRTASFILRSSNSFRNLREIYESPLIAQDNIKYEKKVAQTPEEEGRILTLEAKHSRRQRLMETSPTHSVMDITKVNKTTITISSPKPADKAPPTRPKVNQHYCPPLVQSKRPLPPPPPNSSEHQAPDEDAYSLHSEITGTSEFENSCNNTMSSAISATTEERTHAKGSRSPKINAKIPEEDYEGMYNKKINSLRNDYSLTKYLNRRKSQREEVSKAGPDSPKDVAPEPEFGGSNKSVKEVDVAQFDALSISSRSNRSSSHLSERTKEMYRNAGVPVGIAYPQRAASSSGNASAGGNVQTVYRCEIEQAQLTAGMQIAIGLKDRAKKAKDLKNAWRKFVTMAANKFSPSQSPAPTYGSKTAAGFLEDDGIASIIEDAAQSAGMGQPGSQTYYEQRFGQLDSGYMSTDSTELYKRNVYDRYNFKMPCGRGQIIRVDTIEDNEEESGPNDNRFEDLEHMVSPSHSRRSPENNAVVACDLSDAESDKTLTRSHSQTNSQERNVRGSTTTMSSYSSDENGRGRSTCCGSSETDEETNAEDMWESGAESIETHSVLYKMIRKS
Protein: Protein disulfide isomerase-like 1-3 (AtPDIL1-3) (EC 5.3.4.1) (Protein disulfide isomerase 1) (AtPDI1) (Protein disulfide isomerase-like 2-1) (AtPDIL2-1) (Q8VX13)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000305}.
Interaction partners:
- Endoplasmic reticulum oxidoreductin-1
- Heat shock 70 kDa protein BIP1
- Endoplasmic reticulum oxidoreductin-2
- Calreticulin-2
- Calreticulin-1
- Protein disulfide-isomerase 5-1
- Heat shock 70 kDa protein BIP2
- Heat shock 70 kDa protein BIP3
- Calreticulin-3
- UDP-glucose:glycoprotein glucosyltransferase
Sequence:
MASSSTSISLLLFVSFILLLVNSRAENASSGSDLDEELAFLAAEESKEQSHGGGSYHEEEHDHQHRDFENYDDLEQGGGEFHHGDHGYEEEPLPPVDEKDVAVLTKDNFTEFVGNNSFAMVEFYAPWCGACQALTPEYAAAATELKGLAALAKIDATEEGDLAQKYEIQGFPTVFLFVDGEMRKTYEGERTKDGIVTWLKKKASPSIHNITTKEEAERVLSAEPKLVFGFLNSLVGSESEELAAASRLEDDLSFYQTASPDIAKLFEIETQVKRPALVLLKKEEEKLARFDGNFTKTAIAEFVSANKVPLVINFTREGASLIFESSVKNQLILFAKANESEKHLPTLREVAKSFKGKFVFVYVQMDNEDYGEAVSGFFGVTGAAPKVLVYTGNEDMRKFILDGELTVNNIKTLAEDFLADKLKPFYKSDPLPENNDGDVKVIVGNNFDEIVLDESKDVLLEIYAPWCGHCQSFEPIYNKLGKYLKGIDSLVVAKMDGTSNEHPRAKADGFPTILFFPGGNKSFDPIAVDVDRTVVELYKFLKKHASIPFKLEKPATPEPVISTMKSDEKIEGDSSKDEL
Protein: Transport and Golgi organization protein 1 homolog (Q22666)
Organism: Caenorhabditis elegans
Interaction partners:
- Syntaxin-1A homolog
Sequence:
MGKNFDEAALLKSLEGVPDAEKVQKLIKKLAESEKQNAELKIKVLDYDKVVKVKDLTEKKLERNNQILLRTEEAKSKLEELCRGLQKANHQTREEACAKMKKLEVERGLAVEQLKVTLKDIEKTMAEGRSKSDSLAEDNKKLSEKFSEIGHQYEEKMKVIDQQIQKKEKYWEEYGKTKDLEIKLLTAKLESASIQVKKSGMEKDELAKIMLEETARVGGALKTEKALREQVQEYSAKYSELTSCLSKSNEAFDKFKDEISRVNKKCMQVEKEGLSYKKKSDEANKKVLVLTMTNQEYAEKIATSDKKIQMLENLCRALRKGEQEPVTTAETTEAN
Protein: Rho GTPase-activating protein 39 (Preoptic regulatory factor 2) (PORF-2) (P18890)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Putative preoptic regulatory factor 1
Sequence:
YEQCIAHYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAITKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
Protein: Mitochondrial processing peptidase alpha subunit, putative (Q586V8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Mitochondrial processing peptide beta subunit, putative
- Cytochrome c1, heme protein, mitochondrial
- Reiske iron-sulfur protein, mitochondrial
- Mitochondrial processing peptidase, beta subunit, putative
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Electron transfer protein, putative
- NADH-ubiquinone oxidoreductase, mitochondrial, putative
- Prohibitin
- Mitochondrial processing peptidase alpha subunit, putative
- Acyl carrier protein
Sequence:
MLRHCIPRLGIAKTVIKDNYSLSTLTNGLRVLTCDDGNGVTGMGLFMLNGAKFESPDNAGAAAVFEALPLRDNQIYTSREISQALSGLGNAFKVTNNKEALSVILMLPRYHQRDGLELLNAMCLHPTRNEEEFRIAKEKTHERTLLYDRDATSVCFELVHEAGWNGKGLGHSLNPKKEELDKLTLEKFTAFHSACTRPERTVLAATGVADHKSFAEEVEKLLRFNNADVAVQAMPQLQPGYYPYTGGSRLVHRTEAPESVNKFQEKSLSHVALFFQGVPINHPDYYNISVIQTLLGGGTSFSSGGPGKGMQTKLFREVLNREGFLHGLECITAWYSDGGLFGLYGTAPHQAVVSLLNVMIYQAASICQRVSPTHLEMAKNQLRSQLILLGEGREQLLSDMGFNLVVHNHIITATETMEGTRNITLDDLKRVCADMIKKPLTFTVYGDTTKMPSHESLEETVRKTYEKLN
Protein: Mannan endo-1,4-beta-mannosidase A (EC 3.2.1.78) (Endo-beta-1,4-mannanase A) (Q5B7X2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Endo-1,4-mannanase that catalyzes the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans and heteromannans. It is a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans. Active against locust bean gum and gum guar. Also has transglycosylation activity.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q99036}.
Interaction partners:
- Mannan endo-1,4-beta-mannosidase C
- Phosphotransferase
- Hexokinase
- Phosphotransferase
- Mannan endo-1,4-beta-mannosidase D
- Uncharacterized protein
- Probable mannan endo-1,4-beta-mannosidase E
- GH26 domain-containing protein
Sequence:
MKFSQALLSLASLALAAALPHASTPVYTPSTTPSPTPTPSASGSFATTSGIQFVIDGEAGYFPGSNAYWIGFLKNNSDVDLVFDHMASSGLRILRVWGFNDVNTAPTDGSVYFQLHQDGKSTINTGKDGLQRLDYVVHSAEKHGIKLIINFVNYWDDYGGMNAYMRAYGGGDKADWFENEGIQAAYQAYVEAVVKRYINSTAVFAWELANEPRCTGCEPSVLHNWIEKTSAFIKGLDEKHLVCIGDGSDGSYPFQYTEGSDFAAALTIDTIDFGTFHLYPDSWGTNNDWGKLWITSHAAACAAAGKPCLFEEYGVTSNHCAIEKQWQNAALNATGIAADLYWQYGDTLSSGPSPDDGNTFYYGSEEFECLVTNHVETIERSAK
Protein: Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) (Q9NSV4)
Organism: Homo sapiens (Human)
Function: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18755006, ECO:0000269|PubMed:19457867}. Nucleus {ECO:0000250|UniProtKB:Q9Z207}. Note=During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis (PubMed:18755006, PubMed:19457867). Shuttles between the cytoplasm and the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9Z207, ECO:0000269|PubMed:18755006, ECO:0000269|PubMed:19457867}.
Interaction partners:
- Cell division control protein 42 homolog
- Anillin
- Transforming protein RhoA
- BAR/IMD domain-containing adapter protein 2
- Rho-related GTP-binding protein RhoB
- Protein diaphanous homolog 1
- G2/mitotic-specific cyclin-B1
- Profilin-4
- Flavin reductase
- Biliverdin reductase A
Sequence:
MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETELLGSFSKNESVPEVEALLARLRAL
Protein: At2g44060 (Late embryogenesis abundant protein, group 2) (Similar to late embryogenesis abundant proteins) (O80576)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Late embryogenis abundant protein 2
- Dehydrin HIRD11
- At1g21000/F9H16_1
- Reticulon-like protein B1
- Titan9
- Large ribosomal subunit protein eL14z
- Late embryogenesis abundant protein 18
- Dehydrin ERD14
- Thylakoid lumenal protein TL20.3
Sequence:
MSTSEDKPEIISRVVHQEGDVEIVDRSQKDKDEEKEEGKGGFLDKVKDFIHDIGEKLEGTIGFGKPTADVSAIHIPKINLERADIVVDVLVKNPNPVPIPLIDVNYLVESDGRKLVSGLIPDAGTLKAHGEETVKIPLTLIYDDIKSTYNDINPGMIIPYRIKVDLIVDVPVLGRLTLPLEKCGEIPIPKKPDVDIEKIKFQKFSLEETVAILHVRLQNMNDFDLGLNDLDCEVWLCDVSIGKAEIADSIKLDKNGSGLINVPMTFRPKDFGSALWDMIRGKGTGYTIKGNIDVDTPFGAMKLPIIKEGGETRLKKEDDDDDDEE
Protein: E1 ubiquitin-activating enzyme (EC 6.2.1.45) (Q27481)
Organism: Caenorhabditis elegans
Interaction partners:
- Ubiquitin-conjugating enzyme E2 2
- Ubiquitin-like domain-containing protein
- Ubiquitin-conjugating enzyme E2 13
- UBC core domain-containing protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- Probable ubiquitin-conjugating enzyme E2 7
- Ubiquitin-conjugating enzyme E2 1
- Polyubiquitin-A
- Ubiquitin-conjugating enzyme E2 G2
- Ubiquitin-conjugating enzyme E2 ubc-18
Sequence:
MTTILELTSANKTNNKATNNKLQREGENEYPPAKRSKTDDEEEPTVVGNGTIVGAPKQQTLSGVNQSGNVNVETTKNTEGQDGEKMDTSNNAGGVGGNSDELLDKNLYSRQIYTLGESAMVNLRTASVLISGLGSVGVEIAKNLILGGVRHVTIHDTKLAKWSDLSAQYYLRDADVGHNRATSCYERLAELNDSVNVQVSTDELTEEFVKTFDLVVLTDAARTAQRQIAAWTRAHNRRILITDARGVFSYIFNDFGDNFRIDDATGEQVREFFIEHIDKTTGEVTTLENLFHGLEDGDHVTFSEVKGLTEINGCEPLKITVKNASKFNIGDFAVSFSDYKEGGRCRQVKVPTSVSHVPFEKSLVEPEFGIWDYAKFEYPSQLHALWTALYAFEEKYGRSPAPRSTQDAALLKELIPSGTEEIPEKLIELFSFSASGNLVTVSSVVGGIAAQEAMKGVTHHMTPLKQWLHLDHVEVLPGDWTSFDNSKLSETDCQPRQSRYDGQAAVFGWPYQECLFRQRWFVVGAGAIGCELLKNLSMMGVACGEGGLIKITDMDQIEISNLNRQFLFRRRDVGGKKSECAARAVTAFNSDVRIEALAERVGLETEHIFNDEFFGELNGVANALDNVDARRYMDRRCVYYRLPLLESGTMGTKGNTQVVYPYLTESYSSSVDPPEKEIPVCTLKNFPNEIQHTIQWAREQFETFFAQPGEMANKFLSDERGFNEHVDKLISGQQIDILQKVKDALIDARPSSAEDCIRWARNQFQELYHNNIAQMLHSFPPDQLTDSGAKFWSGAKRCPHVLNFDPSKEEHFNFVFAASILIAELYGVQPILDREEVIRVALSVNPEPFEPKSGVKIAVTDAEAKEQNERGASSMIVDDDAAIEALKLKLATLNVKSTSKLNCVDFEKDDDSNHHMEFITAASNLRAENYDILPADRMRTKQIAGKIIPAIATTTAAVAGLVCIELYKVVDANGIPKTPMERFKNTFLNLSMPFFSSAEPIGAPKKTYMDREFTLWDRIDVQGPLTLQEFIDNVQNQTGGCEVSMLSAGACLLFSFFMNAGKKQERLKTEVKAVYEELLKKSLHPSVHALVLEPMMSDPDGEDVEVPYIRYSF
Protein: Two-pore potassium channel 3 (AtTPK3) (Calcium-activated outward-rectifying potassium channel 6) (AtKCO6) (Q9SVV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Two-pore potassium channel modulating the proton motive force (pmf) necessary to convert photochemical energy into physiological functions. Mediates the potassium efflux from the thylakoid lumen required for the regulation of the transmembrane electrical potential, the enhancement of the pH gradient for ATP synthesis, the regulation of electron flow, and pH-mediated photoprotective responses. Requires calcium for channel activity.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:16984403, ECO:0000269|PubMed:17764516, ECO:0000269|PubMed:19825594, ECO:0000269|PubMed:31053658}; Multi-pass membrane protein {ECO:0000255}. Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:24009357}; Multi-pass membrane protein {ECO:0000255}. Note=PubMed:24009357 shows a thylakoid location instead of the tonoplast location previously described.
Interaction partners:
- K
- Chloride channel protein CLC-e
- Potassium channel AKT2/3
- K
- Potassium channel AKT1
- K
- Two pore calcium channel protein 1
- K
- F-actin-capping protein subunit alpha
- Probable potassium channel AKT5
Sequence:
MANEGSDPLLQYMISPRLKKPPQLLFPLPEDNEVAIPMPMTPSEFKERLIFGPFSCSPRDSSHFIDSMKQPSPSSSSTAVNNPFSDSSTLDPLLPPPPPQPEPWLSDQTSSHCQGHALHRSKTAPAMAVINDLHHPIRQKDPTETSRSVVRQAFALLVVYLSLGVLIYWLNRDHYVVNQTHPVVDGLYFCIVTMCTIGYGDITPNSVVTKLFSIMFVLVGFGFIDILLSGMVSYVLDLQESYMLDSAKRRDEPEKRRSYIIDVKKGRMRIRLKVALALGVVVLCIAVGVGIMHFIEEIGWLDSFYLSVMSVTTVGYGDRAFKTLPGRLFAAIWLLVSTLAVARAFLYLAEARVDKRNRERAKKVLCETMSVSQFFAADIDNNGCVSKAEYVIYKLKEMEKITDKDILPISKQFDKLDRCSNGKITLLDLLEGGSGD
Protein: Bromodomain containing 8 (Q6PFM2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRSGDQNWVSVSRAIKPFSESGRPPDWFSQKHCASQYSQLLETTEAPKRKRGEKGEVVETIEDVIVRRLTAERIEELKRLIKDTQEKYRKLKKEVDLIQAGHVDPKLEELWAEIELKKKQEEEEAEQKKRATEAAYQIRQAAKNTPKRVPSVTVRSPPGASSPSMDILQPDASQPMTDESCASPMAQGVTVFMPVSDVMGPGPKESGLSSLVDDSPQKKHLAPKATPPPSPLLSELLKKGSLIAASSRLVVEGEVATGLSNGSHAVELHTSATVLPATQDITADAPTLSRLLESVTPAQQPVSADPPKPPTVVPPAPDHLSVPKTGDAAVAEGSGAEAVMAGSSTPAEVEGKETELVEEDTVVSVSYMGHELDLGTVGDIIAIIEEKVDDPVEALDAAAVEAALSLCEDPAVGGHPLTSPWESQTFKAAEPEPMIQQSAIPAGAETVPNSASVQGEMEVLVEEATETEAVEGVTEEPEVPSAPETEQSQDSEVKTEVEREGEGEGGVEETAQPENRTPSPAVKCEGEDWVQPETVTPCLDSEDSSASAKDAKDVKEEDGGSEVDVDEGMEMKECGDGDGEGPYLSEVDPPASESEDGYGSHSQRYTTADSTASSPASSQFSMCSEDQEALQAQKIWKKAIMLVWRAAANHRYASVFLQPVSDDIAPGYHSIVHRPMDLSAIKKNIESGQIRTTAEFQRDIMLMFQNAVMYNSSDHDVYHMALEMQRDVLEQIQQFLATRLIMQTSESGISTKSLRGREANRKQDPNEKTLSPAHKEPHLEPEPPARRKRNNSKQDTVEKDGGTRGRRSAIEADMKMKK
Protein: Kinesin-like protein (G5EFQ4)
Organism: Caenorhabditis elegans
Interaction partners:
- CILiary localization
- Cytosolic carboxypeptidase 1
- Kinesin-associated protein
- Polycystin-2
- Location of vulva defective 1
- Tubulin polyglutamylase ttll-4
- Tubulin alpha chain
- Tubulin polyglutamylase ttll-5
- Tubulin beta-4 chain
- Kinesin-like protein
Sequence:
MGKGDSIIVAVRVRPFNDREKTRNCKLVIEMPDEETTVIRDPKTNDEKRFTYDHSYWSHDGFSEKKNGYLEPTDPHYADQRRVFEDLGRGVLANAWAGYNCSLFAYGQTGSGKSYSIVGFKNNKGIVPIVCEELFKQIADNKKKNMQFEVFVSMMEIYCEKVRDLLSSTPPPKGGLKVREHPKNGFYVENLTTVPVNSFKEIEAKIEEGTKSRTIAATQMNATSSRAHTIVKITFNQKSSKQAGGTSMKKSEINLVDLAGSERQSAAGTEGDRLKEGIVINQSLTTLGRVIKALHDSQKAKSGKKTQIPYRDSVLTCLLKNALGGNSKTIMIAAISPADINFEETLSTLRFADRAKSIKTNAVVNENQTERALRELREENLRLQSQIQGGTAGDASNEEIEKLRRQLAENQKEMEEMEKSWQQKIAEEAAKHASGASEKVEMEAKKKKMCHLWNLNEDPALTNVIVHFIPVGESVVGNKPTSSGNFIQMSGLSILPQHVTLKNDGNNQIHLSPCSEDLDIFINGKPVHGETQLQQNDRVFFGGNHLYVFNNPTKKGIRTDITYENAQAEIAQNHAAALGNRGLGGGSKRDLILEEELMSTLPLVQRANAMATELGRNVKFEIVLVSPEMRGLTSGLTEIWVKVHNISEDTYFLWEKSRFMNRYYGMQEMYEAKQDGSEDWNMPKERDPFYEPPDSPVFIASSVVFLQSLAYLIDVEEQFPIVDLSGQEIGLLTVGLSPCSTTGKELRGEYVEDPDQLIGKNIAFKVKVISAVGLPRRILKSNCKYRFFGSKKMTTTATVSGNTPAYGHEETFQFKPVTKEVADYLANSNLYITFWGTQRPRGASSRKNSISTIGSNEAREGPNKAKRVERLVHQAKTSENRNISVKALETVLKGVDDNENRKTRKQSMKKAGSTTIKSRSGSKKPKAK
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (B1H230)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 3
- mitogen-activated protein kinase
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 13
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Mitogen-activated protein kinase 8
- mitogen-activated protein kinase kinase kinase
- mitogen-activated protein kinase kinase
- Mitogen-activated protein kinase 1
Sequence:
MESPAASPPASLPQTKGKSKRKRDLRISCVSKPPVSNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS