wanglab/gogpt-training-data huggingface dataset:
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A178WK49)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MQIGKLIWVIMFIFVHIIITSSRSFSDSIITEREILLQFKDNINDDPYNSLASWVSNADLCNSFNGVSCNQEGFVEKIVLWNTSLAGTLTPALSGLTSLRVLTLFGNRITGNLPLDYLKLQTLWKINVSSNALSGLVPEFIGDLPNLRFLDLSKNAFFGEIPNSLFKFCYKTKFVSLSHNNLSGSIPESIVNCNNLIGFDFSYNGITGLLPRICDIPVLEFVSVRRNLLSGDVFEEISKCKRLSHVDIGSNSFDGVASFEVIGFKNLTYFNVSGNRFRGEIGEIVDCSESLEFLDASSNELTGNVPSGITGCKSLKLLDLESNRLNGSVPVGMGKMEKLSVIRLGDNFIDGKLPLELGNLEYLQVLNLHNLNLVGEIPEDLSNCRLLLELDVSGNGLEGEIPKNLLNLTNLEILDLHRNRISGNIPPNLGSLSRIQFLDLSENLLSGPIPSSLENLKRLTHFNVSYNNLSGIIPKIQASGASSFSNNPFLCGDPLETPCNALRTGSRSRKTKALSTSVIIVIIAAAAILVGICLVLVLNLRARKRRKKREEEIVTFDTTTPTQASTESGNGGVTFGKLVLFSKSLPSKYEDWEAGTKALLDKDNIIGIGSIGAVYRASFEGGVSIAVKKLETLGRIRNQEEFEQEIGRLGSLSHPNLASFQGYYFSSTMQLILSEFVTNGSLYDNLHPRVSHRTSSSSSSHGNTELNWHRRFQIAVGTAKALSFLHNDCKPAILHLNVKSTNILLDERYEAKLSDYGLEKFLPVLNSSGLTKFHNAVGYIAPELAQSLRVSDKCDVYSYGVVLLELVTGRKPVESPSENEVVILRDHVRNLLETGSASDCFDRRLRGFEENELIQVMKLGLICTTENPLKRPSIAEVVQVLELIRNGMES
Protein: DNA mismatch repair protein MLH1 (MutL protein homolog 1) (Protein MUTL-HOMOLOGUE 1) (AtMLH1) (Q9ZRV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.
Subcellular location: Nucleus {ECO:0000269|PubMed:16467846, ECO:0000269|PubMed:16856855, ECO:0000269|PubMed:18318687, ECO:0000269|PubMed:20628250, ECO:0000269|PubMed:22844245}.
Interaction partners:
- DNA mismatch repair protein PMS1
- DNA mismatch repair protein MLH3
- DNA mismatch repair protein MSH3
- DNA mismatch repair protein MSH5
- DNA mismatch repair protein MSH7
- DNA mismatch repair protein MSH6
- DNA mismatch repair protein MSH2
- Exonuclease 1
- DNA mismatch repair protein MSH4
- DNA mismatch repair protein MSH1, mitochondrial
Sequence:
MIDDSSLTAEMEEEESPATTIVPREPPKIQRLEESVVNRIAAGEVIQRPVSAVKELVENSLDADSSSISVVVKDGGLKLIQVSDDGHGIRREDLPILCERHTTSKLTKFEDLFSLSSMGFRGEALASMTYVAHVTVTTITKGQIHGYRVSYRDGVMEHEPKACAAVKGTQIMVENLFYNMIARRKTLQNSADDYGKIVDLLSRMAIHYNNVSFSCRKHGAVKADVHSVVSPSRLDSIRSVYGVSVAKNLMKVEVSSCDSSGCTFDMEGFISNSNYVAKKTILVLFINDRLVECSALKRAIEIVYAATLPKASKPFVYMSINLPREHVDINIHPTKKEVSLLNQEIIIEMIQSEVEVKLRNANDTRTFQEQKVEYIQSTLTSQKSDSPVSQKPSGQKTQKVPVNKMVRTDSSDPAGRLHAFLQPKPQSLPDKVSSLSVVRSSVRQRRNPKETADLSSVQELIAGVDSCCHPGMLETVRNCTYVGMADDVFALVQYNTHLYLANVVNLSKELMYQQTLRRFAHFNAIQLSDPAPLSELILLALKEEDLDPGNDTKDDLKERIAEMNTELLKEKAEMLEEYFSVHIDSSANLSRLPVILDQYTPDMDRVPEFLLCLGNDVEWEDEKSCFQGVSAAIGNFYAMHPPLLPNPSGDGIQFYSKRGESSQEKSDLEGNVDMEDNLDQDLLSDAENAWAQREWSIQHVLFPSMRLFLKPPASMASNGTFVKVASLEKLYKIFERC
Protein: DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) (Q58WW2)
Organism: Homo sapiens (Human)
Function: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:15784617}.
Interaction partners:
- DNA damage-binding protein 1
- Cullin-4A
- Cullin-4B
- DDB1- and CUL4-associated factor 4
- DDB1- and CUL4-associated factor 12
- DNA damage-binding protein 2
- DDB1- and CUL4-associated factor 5
- DDB1- and CUL4-associated factor 10
- DDB1- and CUL4-associated factor 1
- Short transient receptor potential channel 4-associated protein
Sequence:
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENENEDEE
Protein: Glutamyl-tRNA (Gln) amidotransferase subunit C (Q949X1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MFARRLSSLFSIVTKRSQSRLLSCPTTSAQNWVFAEFRQTIQATRFYASGRGKDYNLFGNVKPGDDDFRKTWEKEMEDDDTLWSGSEDESNDKTKQESGRNRLEKEIKKARQQAKDSTDQIDGDDSDELYSVWSGSDEEKTLWTGDEGDDDDDIPTEPRPNEASDKYLDKLFEFEEKPKYRTISELLKSENEPEELSPGKKARKLAVENALKKLNKGPDGRYTNVWEVMSDVDILIGAFENIISGPEYEELRKGGPKRLNMQFFKDIQTRMRDPNFKFTPEIKLKPKSKLVPRKKWQKAQSRIRKAKKR
Protein: D-serine transporter DsdX (D-serine-specific permease) (A0A0H2VAP9)
Organism: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Function: Protein that allows transport of D-serine across the inner membrane, does not transport D-alanine nor probably glycine. Is probably a H(+) symporter, as CCCP inhibits transport. Transports D-serine more efficiently than CycA.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:P08555}; Multi-pass membrane protein.
Interaction partners:
- D-serine dehydratase
Sequence:
MHSQIWVVSTLLISIVLIVLTIVKFKFHPFLALLLASFFVGTMMGMGPLDMVNAIESGIGGTLGFLAAVIGLGTILGKMMEVSGAAERIGLTLQRCRWLSADVIMVLVGLICGITLFVEVGVVLLIPLAFSIAKKTNTSLLKLAIPLCTALMAVHCVVPPHPAALYVANKLGADIGSVIVYGLLVGLMASLIGGPLFLKFLGQRLPFKPVPTEFADLKVRDEKTLPSLGATLFTVLLPIALMLVKTIAELNMARESGLYTLLEFIGNPITATFIAVFVAYYVLGIRQHMSMGTMLTHTENGFGSIANILLIIGAGGAFNAILKSSSLADTLAVILSNMHMHPILLAWLVALILHAAVGSATVAMMGATAIVAPMLPLYPDISPEIIAIAIGSGAIGCTIVTDSLFWLVKQYCGATLNETFKYYTTATFIASVIALAGTFLLSFII
Protein: Vacuolar-sorting protein snf7 (Vacuolar protein-sorting-associated protein 32) (Q9P7F7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB).
Subcellular location: Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting-associated protein 24
- pH-response regulator protein palA/rim20
- ESCRT-III complex subunit did4
- Suppressor protein of bem1/bed5 double mutants
- Vacuolar protein-sorting-associated protein 46
- Charged multivesicular body protein 7
- Vacuolar protein sorting-associated protein 20
- Vacuolar protein-sorting-associated protein 36
- Vacuolar protein-sorting-associated protein 25
- Vacuolar protein sorting-associated protein 28 homolog
Sequence:
MSGFLRWFGGNRSKDTTKDTIVRFQEMLALYDKKEEVLERQIAEQTEIARKNATTNKRLALTALKRKKMHENELVKIEGSRNNIEQQLFSIQNANLNFETLQAMRQGAEAMKSIQRGMDADKVDQIMDKIRDQQTISEEISTMISTPVGLNAEIDEDELANELDELQQMELDSKMLGAEKPPVHTPAVPAVPSQVKDLPSISKPQELDEEEELRKLQAEFSL
Protein: D-aminoacyl-tRNA deacylase 2 (EC 3.1.1.96) (Animalia-specific tRNA deacylase) (ATD) (D-tyrosyl-tRNA(Tyr) deacylase 2) (L-alanyl-tRNA deacylase) (Q96FN9)
Organism: Homo sapiens (Human)
Function: Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS. Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site. Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- D-aminoacyl-tRNA deacylase 1
Sequence:
MAEGSRIPQARALLQQCLHARLQIRPADGDVAAQWVEVQRGLVIYVCFFKGADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCAEARVVVEHGTYGNRQVLKLDTNGPFTHLIEF
Protein: Sm-like protein LSm1 (SPB8 protein) (P47017)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex binds RNA with a preference for poly-U ends.
Subcellular location: Nucleus {ECO:0000269|PubMed:10761922}. Cytoplasm {ECO:0000269|PubMed:10761922}. Cytoplasm, P-body {ECO:0000305|PubMed:10913177}.
Interaction partners:
- LSM2-LSM8 complex subunit LSM8
- ATP-dependent RNA helicase DHH1
- LSM complex subunit LSM4
- 5'-3' exoribonuclease 1
- LSM complex subunit LSM2
- LSM complex subunit LSM6
- Deadenylation-dependent mRNA-decapping factor PAT1
- LSM complex subunit LSM7
- LSM complex subunit LSM3
- m7GpppN-mRNA hydrolase
Sequence:
MSANSKDRNQSNQDAKRQQQNFPKKISEGEADLYLDQYNFTTTAAIVSSVDRKIFVLLRDGRMLFGVLRTFDQYANLILQDCVERIYFSEENKYAEEDRGIFMIRGENVVMLGEVDIDKEDQPLEAMERIPFKEAWLTKQKNDEKRFKEETHKGKKMARHGIVYDFHKSDMY
Protein: Ras-related protein Rab-21 (Ras-related protein RabB) (P34142)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in the regulation of phagocytosis.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Calponin homology and LIM domain-containing protein
- LIM domain-containing protein F
- Rab GDP dissociation inhibitor
- Rab escort protein 1
Sequence:
MTDTEKSFKVVLLGEGCVGKTSIVFRYIDNIFNDKHLMTQHAGFFQKHINIGGKRICLTIWDTAGQERFHALGPIYYRGSQGALVVYDITDNDSFIKAKNWIKELKTMLGNDISLCIIGNKCDLEKTRVIPLADAEAYAKSVGAIHYSTSAKLNKGIEELFLDLTRRMILNSSGVVIHSNTNTTGQTTNRSERIPIVPDSDSGNKQPGCCSN
Protein: Abscisic acid receptor PYR1 (ABI1-binding protein 6) (Protein PYRABACTIN RESISTANCE 1) (Regulatory components of ABA receptor 11) (O49686)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA. Can be activated by both (-)-ABA and (+)-ABA. Promotes drought tolerance.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9FLB1}. Cytoplasm, cytosol {ECO:0000269|PubMed:29928509}. Nucleus {ECO:0000269|PubMed:25465408}. Cell membrane {ECO:0000269|PubMed:25330042, ECO:0000269|PubMed:25465408}. Vacuole {ECO:0000269|PubMed:27495812}. Note=Localizes at the plasma membrane in the presence of a CAR protein (By similarity). Localized transiently in the vacuole when in complex with RSL1 (PubMed:27495812). {ECO:0000250|UniProtKB:O80920, ECO:0000269|PubMed:27495812}.
Interaction partners:
- Protein phosphatase 2C 56
- Protein phosphatase 2C 16
- Protein phosphatase 2C 77
- Protein phosphatase 2C 37
- Protein phosphatase 2C 7
- Probable protein phosphatase 2C 75
- Protein phosphatase 2C 3
- Probable protein phosphatase 2C 78
- Serine/threonine-protein kinase SRK2E
- Probable protein phosphatase 2C 24
Sequence:
MPSELTPEERSELKNSIAEFHTYQLDPGSCSSLHAQRIHAPPELVWSIVRRFDKPQTYKHFIKSCSVEQNFEMRVGCTRDVIVISGLPANTSTERLDILDDERRVTGFSIIGGEHRLTNYKSVTTVHRFEKENRIWTVVLESYVVDMPEGNSEDDTRMFADTVVKLNLQKLATVAEAMARNSGDGSGSQVT
Protein: Alpha-synuclein (B5G014)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted {ECO:0000256|ARBA:ARBA00004613}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGGVYVGSRTKEGVVHGVTTVAEKTKEQVSNVGGAVVTGVTAVAQKTVEGAGNIAAATGLVKKDQLAKQNEEGFLQEGMVNNTGVAVDPENEAYEMPPEEEYQDYEPEA
Protein: uroporphyrinogen-III C-methyltransferase (EC 2.1.1.107) (G3XD80)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Pre-heme d1 synthase
- Siroheme decarboxylase NirL subunit
- Protein NirF
- Dihydro-heme d1 dehydrogenase
- Siroheme decarboxylase NirG subunit
- Siroheme decarboxylase NirH subunit
- Siroheme decarboxylase NirD subunit
- Porphobilinogen deaminase
- Heme biosynthesis operon protein HemX
- Cytochrome c-551
Sequence:
MNTTVIPPSLLDVDFPAGSVALVGAGPGDPGLLTLRAWALLQQAEVVVYDRLVARELIALLPESCQRIYVGKRCGHHSLPQEEINELLVRLARQQRRVVRLKGGDPFIFGRGAEELERLLEAGVDCQVVPGVTAASGCSTYAGIPLTHRDLAQSCTFVTGHLQNDGRLDLDWAGLARGKQTLVFYMGLGNLAEIAARLVEHGLASDTPAALVSQGTQAGQQVTRGALAELPALARRYQLKPPTLIVVGQVVALFAERAMAHPSYLGAGSPVSREAVACA
Protein: At1g25320/F4F7_17 (Leucine-rich repeat protein kinase family protein) (Leucine-rich repeat receptor-like protein kinase) (Q9FRI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Transcription factor bHLH75
- Myb domain protein 116
Sequence:
MSVGSLLFMFLLIWNFNGELNALNDEGFALLTLKQSISKDPDGSLSNWNSENQNPCSWNGVTCDDNKVVVSLSIPKKKLLGYLPSSLGLLSNLRHLNLRSNELSGNLPVELFKAQGLQSLVLYGNFLSGSIPNEIGDLKFLQILDLSRNSLNGSIPESVLKCNRLRSFDLSQNNLTGSVPSGFGQSLASLQKLDLSSNNLIGLVPDDLGNLTRLQGTLDLSHNSFSGSIPASLGNLPEKVYVNLAYNNLSGPIPQTGALVNRGPTAFLGNPRLCGPPLKDPCLPDTDSSSTSHPFVPDNNEQGGGGSKKGEGLSKTAIVAIVVCDFIGICIVGFLFSCCYLKICARRNSVDEEGYVLEKEGKEKKGSFCFRRDGSESPSSENLEPQQDLVLLDKHIALDLDELLKASAFVLGKGGNGIVYKVVLEDGLTVAVRRLGEGGSQRCKEFQTEVEAIGKLRHPNIVSLKAYYWSVEEKLLIYDYIPNGSLTNALHGNPGMVSFKPLSWGVRLKIMRGISRGLVYLHEFSPKKYVHGSLKLSNILLGQDMEPHISDFGLMHLSSIAGTLESTTVDRPSNKTASSIGSSANLSSFYLAPEATKATVKPSQKWDVYSFGVILLEMITGRLPIVFVGKSEMEIVKWIQMCIDEKKEMSDILDPYLVPNDTEIEEEVIAVLKIAMACVSTSPEKRPPMKHIADALTQICLQ
Protein: GH11294p (SET and MYND domain containing, arthropod-specific, member 1) (Q7K561)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD27406p
- SET and MYND domain containing, class 4, member 1, isoform B
- Uncharacterized protein, isoform C
- SET and MYND domain-containing protein 4
- SET and MYND domain containing, class 4, member 3
- RE32936p
Sequence:
MNPCHVCEEPTKNKCSNCNQVSYCSVQHQKQDWKVHKPSCHPFKIAHNEQLGRHLVATRTIKPYEIVLKEAPLVRGPAQISAPVCLGCLNGIEAEDHIECEQCGWPLCGPECKSLDEHKAECGLTKDRGQKVNVQEFGGPHPLYTCLSTVRCLLIGETSTEKASKFQDLESLESTRRGSNQWKADLVSIGQFIPKFFKTQKFTEEEIMKAVGALQINGHEVPTTDPSHVAVFYTASFTENSCLPNLAKSFNKNGHCILWAPREIKKNAHLSICYSDAMWGTADRQRHLMQTKLFKCACERCVDVTELDTNYSAIKCEDRQCGGLMLPTKADEWNGSWRCRECHKQVQKHYVERILERAGKDIQSMEKIAENGLKYLKHYEKWLPPQHFHMSEIKILLVQLLAKDQKELMVIPDDRLLLKLNFARELVELYEKLTPCEVRTLGTLCFELHSAIAEQTRRVALETSLSPKDRLEESLFYVDKCVNYLKYESDIFIEGHVLKQAKINRDALRMVMS
Protein: Gibberellin 2-beta-dioxygenase 2 (EC 1.14.11.13) (GA 2-oxidase 2) (Gibberellin 2-beta-hydroxylase 2) (Gibberellin 2-oxidase 2) (Q9XFR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the 2-beta-hydroxylation of several biologically active gibberellins, leading to the homeostatic regulation of their endogenous level. Catabolism of gibberellins (GAs) plays a central role in plant development. Converts GA9/GA20 to GA51/GA29 and GA4/GA1 to GA34/GA8.
Interaction partners:
- Ent-kaur-16-ene synthase, chloroplastic
- Ent-kaurene oxidase, chloroplastic
- Ent-copalyl diphosphate synthase, chloroplastic
- DELLA protein GAI
- DELLA protein RGA
- DELLA protein RGL2
- Gibberellin 3-beta-dioxygenase 2
- Gibberellin receptor GID1B
- Gibberellin 3-beta-dioxygenase 4
- Gibberellin 3-beta-dioxygenase 1
Sequence:
MVVLPQPVTLDNHISLIPTYKPVPVLTSHSIPVVNLADPEAKTRIVKACEEFGFFKVVNHGVRPELMTRLEQEAIGFFGLPQSLKNRAGPPEPYGYGNKRIGPNGDVGWIEYLLLNANPQLSSPKTSAVFRQTPQIFRESVEEYMKEIKEVSYKVLEMVAEELGIEPRDTLSKMLRDEKSDSCLRLNHYPAAEEEAEKMVKVGFGEHTDPQIISVLRSNNTAGLQICVKDGSWVAVPPDHSSFFINVGDALQVMTNGRFKSVKHRVLADTRRSRISMIYFGGPPLSQKIAPLPCLVPEQDDWLYKEFTWSQYKSSAYKSKLGDYRLGLFEKQPLLNHKTLV
Protein: Replication protein A 70 kDa DNA-binding subunit A (OsRPA70a) (Replication factor A protein 1A) (Replication protein A 1A) (Q6YZ49)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Plays an essential role in meiotic and somatic DNA repair, but is dispensable for DNA replication and homologous recombination. Is essential for normal progression through meiosis in pollen mother cells. Is involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Replication protein A 32 kDa subunit B
- Replication protein A 32 kDa subunit A
- Replication protein A 32 kDa subunit C
- Replication protein A 70 kDa DNA-binding subunit C
- Replication protein A 70 kDa DNA-binding subunit B
- ATP-dependent DNA helicase
- Os01g0660500 protein
- DNA polymerase delta catalytic subunit
- Proliferating cell nuclear antigen
- DNA replication ATP-dependent helicase/nuclease
Sequence:
MAMARLTPNGVAAALAGDTNLKPVLQIVELRGVQVNGAGVTRGERFRAVVSDGTAASSALFAAQLSDHARSGALRRGSIVQLSEYVINEVGPRRIIVILNLEVLVSECEIIGNPTALSETGSPIPNPTRVEQFNGAPQYGLMAGNSSNTTTKPSDNVPLFQNSMAGNSSNFATRPSDKVPVFQPTVQPSYRPAPNYKNHGAIMKNEAPARIIPISALNPYQGRWAIKARVTAKGDIRRYHNAKGDGKVFSFDLLDSDGGEIRVTCFNALLDRFYEVVEVGKVYVVSRGNLRPAQKNYNHLNNEWEILLENGSTVDLCPDENSSIPTQRFDFRPINEIEDAQNNAILDIIGVVTSVNPCTTIQRKNGMETQKRTMNLKDMSGRSVEVTMWGDFCNREGSQLQGMVERGIFPVLAVKAGKVSDFSGKSVGTISSTQLFINPDSAEAHSLRQWFDSGGRDASTQSISRDITPGASRNEIRKTVAQIKDEGLGMGDKPDWITVKATVIFFKNESFFYTACPNMIGDRQCNKKVTKSTNGNWTCDKCDREFEECDYRYLLQFQIQDHSGTAWVTAFQEAGQELLGCSATELNALKEREDPRFADTMLNCLFQEYLLRLKVKEESYGDERKVKNTAVKVEKVDPSGESKFLLDLISKSSALH
Protein: T-complex protein 11 (Testis-specific protein PBS13) (Q01755)
Organism: Mus musculus (Mouse)
Function: Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:27105888, ECO:0000269|PubMed:9322250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:27105888, ECO:0000269|PubMed:9322250}. Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm (PubMed:9322250). Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm (PubMed:27105888). {ECO:0000269|PubMed:27105888, ECO:0000269|PubMed:9322250}.
Interaction partners:
Sequence:
MPDVKERAARKEPGAAESASRESRGGNTRESASSARGTDRVGSTVARARPPSPQGPRRGAVKTAPRGPVGHGGLRTGPTSRCPQPSARAKLPSVTRGAPLPPSPGKGHLGGTPSSHRLGMTERVHDASKLDCQLEERSLSSSSLKGKVKDTMPSDFWEHLNEQLSAVPPDFSCALELLKEIKEILLSLLLPRQSRLKNEIEEALDMEFLQQQADRGDLNVSYLSKYILNMMVLLCAPIRDEAVQRLENISDPVRLLRGIFQVLGQMKMDMVNYTIQSLQPQLQEHSVQFERAQFQERLNKEPRLLNHTTKWLTQAATQLIAPSASSSDLQDCSSSAGPSPSDVAVPEPLSPAMVLSQGFLNLLTWDPENEEFPETLVADRPRLQELESQQSQLTILASVLLVASSFSDSGLFSSPQFVDKLKQITKSLVEDFNSRPEEVMQSVSEQVVEEVHQGLESMGLAALSSENTASLVGQLQNIAKKENCVRSVIDQRIHLFLKCCFVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFAPYYTEILKTLISPAQTLATKGGSL
Protein: Gap junction protein (Q8K4M6)
Organism: Cavia porcellus (Guinea pig)
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}.
Interaction partners:
- Gap junction protein
- Gap junction protein
- Solute carrier family 26 member 4
Sequence:
MDWGALHAILGGVNKYSTSIGKIWLTVLFIFRVMILVVATKEVWGDEQADFTCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRKHEKKRRFIKGEMKSEFKDIEEIKNEKIRIEGSLWWTYTTSIFFRVIFEGAFMYVFYIMYNGFFMQRLVKCNAWPCPNTVDCFISRPTEKTVFTVFMIVVSGICILLNITELCYLFIRYCSKKSKKPV
Protein: Small ribosomal subunit protein uS7A (40S ribosomal protein S5a) (Q24186)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein uS11A
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein eL8
- Small ribosomal subunit protein eS10B
- Large ribosomal subunit protein eL19
- Small ribosomal subunit protein eS26
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein eL43
- Small ribosomal subunit protein uS8A
Sequence:
MAEVAENVVETFEEPAAPMEAEVAETILETNVVSTTELPEIKLFGRWSCDDVTVNDISLQDYISVKEKFARYLPHSAGRYAAKRFRKAQCPIVERLTCSLMMKGRNNGKKLMACRIVKHSFEIIHLLTGENPLQILVSAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR
Protein: CBL-interacting serine/threonine-protein kinase 14 (EC 2.7.11.1) (SNF1-related kinase 3.15) (SOS2-like protein kinase PKS24) (Serine/threonine-protein kinase SR1) (AtSR1) (Q9LZW4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19832944, ECO:0000269|PubMed:25058458}. Nucleus {ECO:0000269|PubMed:19832944, ECO:0000269|PubMed:25058458}. Note=Targeted to the tonoplast when interacting with CBL2 or CBL3 and to the cell membrane when interacting with CBL8.
Interaction partners:
- Calcineurin B-like protein 2
- Calcineurin B-like protein 3
- Calcineurin B-like protein 8
- Calcineurin B-like protein 4
- Calcineurin B-like protein 1
- Calcineurin B-like protein 9
- Calcineurin B-like protein 10
- Single-stranded DNA-binding protein WHY1, chloroplastic
- Calcineurin B-like protein 5
Sequence:
MVDSDPVEFPPENRRGQLFGKYEVGKLVGCGAFAKVYHGRSTATGQSVAIKVVSKQRLQKGGLNGNIQREIAIMHRLRHPSIVRLFEVLATKSKIFFVMEFAKGGELFAKVSKGRFCEDLSRRYFQQLISAVGYCHSRGIFHRDLKPENLLLDEKLDLKISDFGLSALTDQIRPDGLLHTLCGTPAYVAPEVLAKKGYDGAKIDIWSCGIILFVLNAGYLPFNDHNLMVMYRKIYKGEFRIPKWTSPDLRRLLTRLLDTNPQTRITIEEIIHDPWFKQGYDDRMSKFHLEDSDMKLPADETDSEMGARRMNAFDIISGSPGFNLSGLFGDARKYDRVERFVSAWTAERVVERLEEIVSAENLTVAKKETWGMKIEGQKGNFAMVVEINQLTDELVMIEVRKRQRAAASGRDLWTDTLRPFFVELVHESDQTDPEPTQVHTTS
Protein: Male determiner protein Yob (P0DP77)
Organism: Anopheles gambiae (African malaria mosquito)
Function: Male determiner protein (M-factor) that controls male somatic sexual differentiation. Acts as a dominant factor that regulates the mRNA splicing of doublesex (dsx) transcripts and promotes expression of male splice forms of dsx.
Interaction partners:
- Protein alan shepard
- Regulator of telomere elongation helicase 1 homolog
- AGAP013112-PA
- Probable methylthioribulose-1-phosphate dehydratase
- AGAP009368-PA
Sequence:
MFSQSACVQVHIKTNELHTAVVEKVILAMISSCRTDNNQALHKLLHVAVCEENYNV
Protein: Os06g0653200 protein (A0A0P0WZT8)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MGGPGASSTMSFEQAFLKNLLLSLQDCSTTKPLDAMSLHERKRAVKSSADFAMATARGGGARWPKAIVLQQQPASTTARARRCGRIVRRCCGRKTRSGAGGGGEMARRLQVRRRAMALRKVIPGGGDAMDEAALLREAMDYVVHLRAQVDVLRRVSEAVQLQRRYTSSTSLRDYSWSKCALKGEEDSSMNMKR