Protein: Origin recognition complex subunit 1 (PfORC1) (EC 3.6.4.-) (Q8I615)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Component of the origin recognition complex (ORC) that binds origins of replication and thus may regulate the initiation of DNA replication (Probable). DNA-binding may not be ATP-dependent. In a SIR2A/Sir2-dependent manner, binds to and silences telomers and subtelomeric repeat regions (TAREs). In a SIR2A/Sir2-dependent manner, binds to promoters of var genes localized next to TAREs resulting in their silencing.
Subcellular location: Nucleus {ECO:0000269|PubMed:16216221, ECO:0000269|PubMed:18525026, ECO:0000269|PubMed:18554328, ECO:0000269|PubMed:19633266, ECO:0000269|PubMed:22379140}. Chromosome, telomere {ECO:0000269|PubMed:18525026, ECO:0000269|PubMed:22379140}. Nucleus, nucleolus {ECO:0000269|PubMed:18525026}. Note=At the late ring stage/early trophozoites, co-localizes with SIR2A/Sir2 to telomeres and subtelomeric regions (TAREs) in the nuclear periphery (PubMed:18525026, PubMed:22379140, PubMed:26094711). Also, partially localizes to the nucleolus (PubMed:18525026). In trophozoites and early schizonts localizes throughout the nucleus (PubMed:18525026, PubMed:26094711). During early-to mid replicating trophozoite stages, colocalizes with PCNA1 and ORC1 to distinct nuclear foci which probably are DNA replication origin sites (PubMed:18554328, PubMed:19633266). In schizonts, relocalizes to the nuclear periphery and cytoplasm (PubMed:18525026, PubMed:26094711). In late schizonts, expression decreases probably due to proteosome-mediated degradation (PubMed:18554328, PubMed:26094711). {ECO:0000269|PubMed:18525026, ECO:0000269|PubMed:18554328, ECO:0000269|PubMed:19633266, ECO:0000269|PubMed:22379140, ECO:0000269|PubMed:26094711}.
Interaction partners:
- ATPase AAA-type core domain-containing protein
- Origin recognition complex subunit 2
- Origin recognition complex subunit 5
- Origin recognition complex subunit 1
- DNA helicase
- DNA helicase
- DNA helicase
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM2
- DNA helicase
Sequence:
MTPKKKIFQNFQANDNEILSPTKKGIKLNVSKLNILNFENTIITKEKTNYEYKASLNKEIDEVLNNNNIINTHNNKKNNLNLYDYNNIKNSTHEFYIDLNEQNKQTIKYNDNKFTPINKKEKYNLDETSSSSISSSLTNISSSLTNISSSLTNISSSLSNSLDEKKKKKKIKKNNSTIINILNNNNNNSNIHHNNKHNIYNKYNISKKPQNKEIHTLPSNHQIKKKSNNTYNTCQQKMKKNISKKNTHSIKNNQNDKNKEKNKEKDKNIKKDRDKDIQTKRTSHQSQDQNNHFERRILRSYTRNNDNVKNNLKNNINNNNTLKRSSQSVRIDSDLSSAHQNKRIKYDEKNIIHRNNNNNNNNNNKTTSNNHNKNNKINNNNPSENYKKQTDTKHTNNTQNNKYNKTKTTNTFKHPSKDHTDVNTKTFKSRYINTYTMEEVQKSIKSNTIKLVQENSCEYQDGIIYESIQINDEEYSIGEDVLIFYTPNNNTYNAKSDDKKNQNNNNIKENIYLLKKGKISSFYKSTNSKVIEVEICFYYDESDEQRIRELEKKQTSRRCKEDFNIYLDDDTKYYNLLGNIHFTILDANYIYKKIYVYNEIETFEEDTHARKGKNKFLCTHFIKDKEDRLCFIPNEDHWDNLVLGSSDLYYYFANEKKLNKNKSLKLIIEKLKINDKINDTQANQKKNNKKEYMNKAQTTTNVKANTHTKTLNDHNKSKTTKNKESSSTSFLQDVKKKSDPHNNDFQSSLKEDQENYYINLLKNIKDPTDKAIRMMQLDVVPKYLPCREKEIKEVHGFLESGIKQSGSNQILYISGMPGTGKTATVYSVIQLLQIKSRKKLLPSFNVFEINGMNVVHPNAAYQVFYKQLFNKKPPNALNSFKIIDRLFNKSQKDNRDVSILIIDEIDYLITKTQKVLFTLFDWPTKINSKLILIAISNTMDLPDRLIPRCRSRLAFGRLVFSPYKGDEIEKIIKERLENCKEIIDHTAIQLCARKVANVSGDIRKALQICRKAFENKRGHKIVPRDITEATNQLFDSPLTNAINYLPWAFKIFLTCLIIELRIINEFVIPYKKVVNRYKILIETSGKYIGMCSDNELFKIMLDKLVKMGILLIRPYIPLENISKNKSKEALLGFNESSKKGNNQKITRAQVSPDIDKESGDMGIELNVETQLIITALMKDPDCSKKLNFY