wanglab/gogpt-training-data huggingface dataset:
Protein: Chromosome-associated kinesin KIF4B (Chromokinesin-B) (Q2VIQ3)
Organism: Homo sapiens (Human)
Function: Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (By similarity). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).
Subcellular location: Nucleus matrix {ECO:0000250|UniProtKB:O95239}. Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Chromosome-associated kinesin KIF4A
- Kinesin-like protein KIF22
- Kinesin-like protein KIF23
- Protein regulator of cytokinesis 1
- Kinesin-like protein KIF11
- Kinesin-like protein KIF2C
Sequence:
MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGETQVVVGTDKSFTYDFVFDPCTEQEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRVIQLLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKSDKNCSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQLQVLLLQAHGGTLPGSINAEPSENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHVACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDETVACTAAAIDTAVEEEAQVETSPETSRSSDAFTTQHALHQAQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKEELVRELQTAKKNVNQAKLSEHRHKLLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSSVLRRKTEEAAAANKRLKDALQKQREVTDKRKETQSHGKEGIAARVRNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKCTFSLSEVHGQVLESEDCITKQIESLETEMELRSAQIADLQQKLLDAESEDRPKQCWENIATILEAKCALKYLIGELVSSKIHVTKLENSLRQSKASCADMQKMLFEEQNHFSEIETELQAELVRMEQQHQEKVLYLVSQLQESQMAEKQLEKSASEKEQQLVSTLQCQDEELEKMREVCEQNQQLLQENEIIKQKLILLQVASRQKHLPNDTLLSPDSSFEYIPPKPKPSRVKEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDGDSDEGDDEEWKPTKLVKVSRKNIQGCSCKGWCGNKQCGCRKQKSDCGVDCSCDPTKCRNRQQGKDSLGTVEQTQDSEGSFKLEDPTEVTPGLSFFNPVCATPNSKILKEMCDMEQVLSKKTAPAPSPFDLPESKHGATEYQQNKPPGKKKKRALASNTSFFSGCSPIEEEAH
Protein: Protein AUXIN SIGNALING F-BOX 2 (Q9LW29)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Confers sensitivity to the virulent bacterial pathogen P.syringae (By similarity). Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. Involved in embryogenesis regulation by auxin.
Subcellular location: Nucleus {ECO:0000269|PubMed:15992545}.
Interaction partners:
- Auxin transporter protein 1
- Auxin-responsive protein IAA7
- Auxin-responsive protein IAA17
- Auxin-responsive protein IAA9
- Auxin-responsive protein IAA3
- Auxin-responsive protein IAA6
- Auxin response factor 6
- F-box/WD-40 repeat-containing protein At5g21040
- Auxin response factor 16
- NEDD8-activating enzyme E1 regulatory subunit AXR1
Sequence:
MNYFPDEVIEHVFDFVTSHKDRNAISLVCKSWYKIERYSRQKVFIGNCYAINPERLLRRFPCLKSLTLKGKPHFADFNLVPHEWGGFVLPWIEALARSRVGLEELRLKRMVVTDESLELLSRSFVNFKSLVLVSCEGFTTDGLASIAANCRHLRDLDLQENEIDDHRGQWLSCFPDTCTTLVTLNFACLEGETNLVALERLVARSPNLKSLKLNRAVPLDALARLMACAPQIVDLGVGSYENDPDSESYLKLMAVIKKCTSLRSLSGFLEAAPHCLSAFHPICHNLTSLNLSYAAEIHGSHLIKLIQHCKKLQRLWILDSIGDKGLEVVASTCKELQELRVFPSDLLGGGNTAVTEEGLVAISAGCPKLHSILYFCQQMTNAALVTVAKNCPNFIRFRLCILEPNKPDHVTSQPLDEGFGAIVKACKSLRRLSLSGLLTDQVFLYIGMYANQLEMLSIAFAGDTDKGMLYVLNGCKKMKKLEIRDSPFGDTALLADVSKYETMRSLWMSSCEVTLSGCKRLAEKAPWLNVEIINENDNNRMEENGHEGRQKVDKLYLYRTVVGTRMDAPPFVWIL
Protein: Uncharacterized protein (Q38CJ0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVDVNGTTILTSTVGGSSQSKCIKNTNDFNNSLTRARKPLGMPQLDEKQLEVGAPESTALNAPFVMHDGLAAPAPPATMENAAPPIGLGGPVLLVGPGSPYNAGNLFTIDNSQGNAAFVTLCQQPSFHYQQPAPQPTVVDQEVALTHKCLQECPRAVLVAALTSLLEEFPLLCPIIRQRCEKATMVLPKQQQHQQQQQQQQQQQHQLQHQQQGITGRFAGLTQSAVPWAAHPPTASYDTQRTTLISTGGNSPQTGGSRKGRGNKSREEGICSLHNNVRSMNHLQLNKQKGVYECVSGFHCLEDGCSGSASPASTKVARTPLAPVGVSQVRGGDGRGVASFAAMSGGNLMASSKLSAPVGSIQAPKDQFSDFMANSLDSGLTPFRGDVSLGNSGIVPCDDPQTAEGSETIDLDSSVVTLKSILHSVRMVAEMEE
Protein: Macrophage scavenger receptor 1 (D3ZDS2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- Calreticulin
- Macrophage mannose receptor 1
- Platelet glycoprotein 4
- Scavenger receptor class B member 1
- Macrosialin
- Apolipoprotein E
Sequence:
MKHNSEKDFQHTTVSFPFPVGQMLKYYVIKILGFNCKKREVDKSVLPSLPAMTKEMIEKQRLCPPEPEDADCYSESVKFDARSMTASLPHNTINGSSVQEKLKSFKVALVALYLLVFAVLIPVVGIVTAQLVNWEMKNCLVGSANTSDTSQTLTGKENTSKAEMGFTIAMERMKALEERVQSISDSKAGLLDTDRFQNFSMATDQRLNDLLLQLNSLISSVQEHGESLDAISKSLQSLNTTLLDVQVHTETLNVKVRESTAKQQEDISKLEERVHKVSAEIQSVKEEQEHVEQEVKQEVKVLNNITNDLRLKDWEHSQTLKNITLIQGPPGPPGEKGDKGLTGQSGPPGVPGARGPPGPKGDQGPVGFPGGRGYPGAPGKAGRSGFPGPKGQKGEKGRAGISTSLKTVRLVDGSGPHEGRVEIFHEGQWGTICDDRWDIRAGQVVCRSLGYQDVLTVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKISKWGELGCSHAEDAGVTCTS
Protein: Enhancer of mRNA-decapping protein 4-like protein pdc1 (EDC4 homolog pdc1) (Partner of decapping enzyme protein 1) (O13892)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:23319050}. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay. {ECO:0000269|PubMed:23319050}.
Interaction partners:
- mRNA decapping complex subunit 2
- Enhancer of mRNA-decapping protein 3
- 5'-3' exoribonuclease 1
- Putative ATP-dependent RNA helicase ste13
- LSM1-LSM7 complex subunit lsm1
- SWIRM domain-containing protein laf1
Sequence:
MNEQDLLNSLRRDLNLPNLGKSHDGSEAVESTFPEKKESSLSAQQPHVDDQRSSLLSLLNAGLNASNQSPSNSGPKYYASHSSSTDALLQAFRDGAKPSGTASGADVKRSDSESTEATSNERPFNPVSAANLERLLMSSTGPQTPINGELKSNDSQDTAFQSSRNMPSDTSVASPDYSHSQSSSPIANYQESGNSEEPHKAEEQQQLSIYQLDNPGSGNYVWETVISPDKFETSTFAKCERNDIAIINRELDAQDNQLIHTNEDFIAYAVHREPIIRVIEISTGKSFLLHNNSPNKFVSVAWGNDSVIKNRLMAIDTTGQVLIFAVDIATSTSEIIFQLSGAQSLSDPIKSRFHWYPKSSTRFAVALSKHIIFFDLDLLNNISFPIPRSINAIQQLPCFLIDTGISAKEYDFSYDGTVFATVDKDALIKIYTVPTTFPSTPDKRPVPSEVSPIAIFTTRMERGPSKNYEKPINLRFISTPGTNNSRYLVIVYVMNQLITLFDLYSKRNIQTFRFNNRPTAATTTSFSQFSVDNERSTLLVGNPPSNSIYFFLFAKDETVSEQAPIYNSTYELILASLNTSEPVPADAKFSVIVAKKFEKAACISFTACKILESEDKYCIVVSNTDGYEYYSIPTSILDKTGKTVRSLESVQNYDADIGGTIDLTERHSTASPSTVNSGFSTPRSQATGFSKKKKDKGERFETKDKSSSVLSPSSYSASTFDAIPMDSIVSNILASLEKSVHKNYESLRSQLLEYKAANEKHTEAILSVVSSTLTENTGKILESVVEKSMQVALKEEIANSVRNALKNNLEKIESFLENSIAELQNSVREDFDKQTSSLAQLRYSIQNVAHAQKESEVKYNELNEQVKTLEGYVETVLEKFNDLKIENKVPETAPDVVPSSYPPAAESNVSVSSDTSTKDVEKQEPSSAEQPAQGIAESLRRLKEYVKAGSVKECVAEWCNMPSVAGFDVLSEISYDRMLENCSNLLLLTFIYHISLLDSVDDDRLSKRMEYISRICLNIDVNDPKVETVVHPVLTLTREALLRQSEFFSPIFKRRLVVLLRALDGKISEISVASSN
Protein: Neuropilin-1a (znrp1) (Q8QFX6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor kdr-like
- Plexin-A4
- Sema domain, immunoglobulin domain
- Plexin-A2
- Semaphorin-3D
- receptor protein-tyrosine kinase
- Plexin A1a.
- Plexin A3
- Vascular endothelial growth factor A-A
Sequence:
MHCGLVLILFTGIFLIVSALKNDKCGDNIRITSANYLTSPGYPVSYYPSQKCIWVITAPGPNQRILINFNPHFDLEDRECKYDYVEVRDGVDENGQLVGKYCGKIAPSPVVSSGNQLFIKFVSDYETHGAGFSIRYEIFKTGPECSRNFTSSSGVIKSPGFPEKYPNNLDCTFMIFAPKMSEIVLEFESFELEPDTQPPAGVFCRYDRLEIWDGFPGVGPYIGRYCGQNTPGRIISYTGTLAMTINTDSAIAKEGFSANFTVLERTVPDDFDCTEPLGMETGEIHSDQIMASSQYSNSWSAERSRLNNPENGWTPLKDTNKEWIQVDLGFLRFVSAIGTQGAISQETKKKYYVKEYKVDVSSNGEDWITIKDGPKQKLFQGNTNPTDVVKAKFPKPTLTRYLRIRPINWETGIALRFEVYGCKISEYPCSGMLGMVSGLITDSQITVSSHIERTWVSENARLLTSRSGWMLLPQSQPYADEWLQIDLAEEKLVKGLIIQGGKHRDNKVFMKKFRLGYSNNGSDWKLVMDATGNKPKIFEGNLNYDTPALRTMEPVLTRFVRIYPDRGTPAGMGLRLELLGCEMEVPTVPPTTPAASTTPSDECDDDQANCHSGTGDGYDQTGGTTATETIREMSTIPAFLWFACDFGWANDPSFCGWISEDSGFRWQIQSSGTPTLNTGPNMDHTGGSGNFIYTLATGAQETEVARLVSPSVSGQDSDLCLSFWYHMFGSHIGTLHIKQRRETSQGSADVLLWTVSGHQGNRWREGRVLIPHSNKPYQVIIESVVERKSWGDIAVDDIKILDNVNMADCKDPDVPAEPIQPEDNFNEIMVDITDFPDIVENPDIGGAGNMLKTLDPILITIIAMSALGVFLGAICGVVLYCACSHSGMSDRNLSALENYNFELVDGVKLKKDKLNSQNSYSEA
Protein: Fimbrial subunit ElfA (P75855)
Organism: Escherichia coli (strain K12)
Function: Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon.
Subcellular location: Fimbrium {ECO:0000269|PubMed:20345943}.
Interaction partners:
- Probable fimbrial chaperone protein ElfD
- Uncharacterized fimbrial-like protein YcbU
- Common pilus major fimbrillin subunit EcpA
- Uncharacterized fimbrial-like protein ElfG
- Probable outer membrane usher protein ElfC
Sequence:
MKKSVLTAFITVVCATSSVMAADDNAITDGSVTFNGKVIAPACTLVAATKDSVVTLPDVSATKLQTNGQVSGVQIDVPIELKDCDTTVTKNATFTFNGTADTTQITAFANQASSDAATNVALQMYMNDGTTAITPDTETGNILLQDGDQTLTFKVDYIATGKATSGNVNAVTNFHINYY
Protein: Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) (Q2NL51)
Organism: Mus musculus (Mouse)
Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors (By similarity). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (By similarity). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer. Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity).
Interaction partners:
- Axin-1
- RAC-alpha serine/threonine-protein kinase
- Catenin beta-1
- Glycogen synthase kinase-3 beta
- RAC-beta serine/threonine-protein kinase
- RAC-gamma serine/threonine-protein kinase
- Adenomatous polyposis coli protein
- Axin-2
- Casein kinase I isoform alpha
- Microtubule-associated protein
Sequence:
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPAGPASPLTTSYNPSSQALTEAQTGQDWQPSDATTATLASSS
Protein: Growth hormone-releasing hormone receptor (GHRH receptor) (Growth hormone-releasing factor receptor) (GRF receptor) (GRFR) (P32082)
Organism: Mus musculus (Mouse)
Function: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Somatoliberin
- Guanine nucleotide-binding protein G
- Pituitary-specific positive transcription factor 1
- Homeobox protein prophet of Pit-1
- Growth hormone secretagogue receptor type 1
- Growth hormone receptor
- Follitropin subunit beta
- Appetite-regulating hormone
Sequence:
MDGLMWATRILCLLSLCGVTLGHLHLECDFITQLRDDELACLQAAEGTNNTSLGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDTGFVKRDCTITGWSNPFPPYPVACPVPLELLTKEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAIFQGDSTDHCSMSTVLCKVSVAISHLATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTECWDLDNSSPCWWIIKGPIVLSVGVNFGLFLNIICILLRKLEPAQGGLHTRAQYWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLDIRVPLELGLGSFQGFIVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRLKVLTSEC
Protein: BTB/POZ domain-containing protein At1g01640 (Q9LQ95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Interaction partners:
- Subtilisin-like protease
- Cullin-1
- Cullin-3A
Sequence:
MTEAEQKAAFLGGLVVSFKEQMHTDVLVKPGEEAPPIPTHKAVLAARSKVFRNMLDSDECKTSPEESITLPDLSHDELKSLLEFLYSGNLKAPYNQYRSLYLAADKYDISYLQDVCRNHFIASLSSRNVLDILELASIPCDTILKDAAINHIVKHMEEVVVPMKYETFVQRNPDLSVEITRAYLRETKAKAKDHGAPLNGNTRPRIW
Protein: Sensor histidine kinase GlrK (EC 2.7.13.3) (P52101)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system GlrR/GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Activates GlrR by phosphorylation.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Transcriptional regulatory protein GlrR
- Uncharacterized protein YfhG
- Transcriptional regulatory protein QseB
- RNA polymerase sigma-54 factor
- KDP operon transcriptional regulatory protein KdpE
- Sensor protein BasS
- Aerobic respiration control sensor protein ArcB
- UPF0283 membrane protein YcjF
- HTH-type DNA-binding transcriptional activator EutR
- Phage shock protein C
Sequence:
MKRWPVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEMERSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLPDDKLYQALRQDLHNLAQLQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQKLIEQLLDYNRKQADSAVELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSKNTK
Protein: Alcohol acyl transferase 1 allele GSc (AAT1-GSc) (EC 2.3.1.-) (A0A498KJ69)
Organism: Malus domestica (Apple) (Pyrus malus)
Function: Involved in the biosynthesis of volatile esters which confer ripe apple fruit flavor (By similarity). Alcohol acyl transferase that can use a wide range of alcohols as substrate to produce esters (By similarity).
Interaction partners:
Sequence:
MMPLAVLQVKRLQPKLITPAKLTPQETKFLSDIDDQEFLRFQVPIIMCYKDNPSLNKNLNPVKVIREALSRALVYYYPLARRLREGPNRKLMVDCNGEGILFIEASADVTLEQLGDKMLPPCPLLEEFLFNFPGSGGIIGCPLVLVQMMTCLTCGGFILALRLNHTMCDAAGLLLFLTAIAEMARGAHAPSILPVWERELLFAPDPPRITCAHHEYEDVIGHSDGSYASSNQSNMVQRSFYFGAKEMRVLRKQIPPHLTSTCSTFDLITACLWKYRTLALNINPKEAVRVSCIVNARGKHNNVRLPLGYYGNAFAFPAAISKAEPLCKNPLGYALELVKKAKATMNEEYLRSVADLLVLRGRPQYSSTGSYLIVSDNTRAGFGDVNFGWGQPVFAGPAKALDLISFYVQHKNNTEDGILVPMCLPSSAMERFQQELERITREPKEDICNNLRSTSQ
Protein: Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7) (Q5PT53)
Organism: Mus musculus (Mouse)
Function: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis (By similarity). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q0GE19}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q0GE19}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q0GE19}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q0GE19}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q0GE19}.
Interaction partners:
- Sodium/bile acid cotransporter 5
- P3 protein
- Sodium-dependent organic anion transporter
Sequence:
MRLLERARKEWFMVGIVVAIGAAKLEPSVGVNGGPLKPEITVSYIAVATIFFNSGLSLKTEELTSALVHLRLHLFIQIFTLAFFPAAIWLFLQLLSVTSINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVVTPVLLLLFLGSSSSVPFTSIFSQLFMTVVVPLVIGQIVRRYIKDWLERKKPPFGVVSSSVLLMIIYTTFCDTFSNPNIDLDKFSLILILFIIVSVQLSFMLLTFIFSTRNNSGFTPADTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLISVPLLIYHPAQILLGSVLVPTIKSWMVSRQKGVKLTRPTV
Protein: HL05328p (LP02926p) (Lectin-24Db) (Q9VQX3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform B
Sequence:
MFRLEKCIVYLLVACNLVESRAESTENSRSVCLLKDPPNQCGEFCLSVLQPLLDHIVKHQEQWNTSEALWLNETQGKLDRIQTQLAAQALSLEESAQKVPGDIKDRLDRMEHLQTTLQESLKKMPAELDARLMKMENQQKTLGDQLENQINLTKESQQDQLEALKNAMPINFEMRLAQIEEQQKLLQETLKKIPEDFERKLQKLEQNQKDELTKLGAQQSANQVTLKEIYTKVFWPKFERIGSRLFYINHKDAYDWQSAVDFCRDMGGYIAAIKDQEELDAISARLDDKSYWLGINDLQSSNTYVSVASGREVEFLNWNAGEPNHGNEDENCVELIRSKMNDDPCHRKKHVICQTDKEV
Protein: Transmembrane channel-like protein 2-A (E7FFT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25114259}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU310713}. Note=Localized to mature hair bundles of the hair cells. {ECO:0000269|PubMed:25114259}.
Interaction partners:
- Transmembrane inner ear.
- Protocadherin-15
- Kinesin family-like.
- Myosin VIb
- Calcium-binding protein 2b.
- CD164 sialomucin-like 2.
- Calcium and integrin-binding family member 2
- Otoferlin
Sequence:
MPKKSDTTRKLEDVGIEIDGDVDSAEEDKKSKGKGGKKAAGGKRGKASEDGEDEDEDDKPPKGRRAANKKKPAPVDEEDSDDDIPQRRSAGNRRRGNVRERGDGDKKKSGKKGRRGGKKNEKGKGKDSDKDSDKDEKKKKNSSGDESDSDEEDESMSEGEMAKLMEEVEEKKKLIANIRNKPWRMRRRLKVLKEAQQFVDKFEGALGKGKGRKLYAYKVMMMKKWIKFKRDFENFRTACIPWERKIKEVESHFGSSVASYFIFLRWMYGMNLVLFSLTFGLVVIPEVLMGLPYGSIPRKTVPREDQDTAMDYSVLTDFNGYCKYSVLFYGYYNNQRTIGFLKFRLPLSYLMVGIGTFGYSLMVVIRTMAKNADVGGGDGEDNEFTFAWKMFTSWDYLIGNAETADNKYASITTSFKESIVDEQENQKDENIHLRRFLRVLANFLITCTLGGSGYLIYFVVKRSQEFQNMDNLSWYEKNELEIIMSLLGLVGPMLFETIAELEEYHPRIALKWQLGRIFALFLGNLYTFLLALFDEVNAKLEEEESIKNASIWFLKEYYANYTANNPNDTGTPPPINPADAIRGPCWETTVGVEFVKLTISDIQVTYLTILIGDFLRAFIVRFLNYCWCWDLEAGWPSYGEFDISGNVLGLVFNQGMIWMGAFYAPGLVGINVLRLLSSMYYQCWAVMACNVPHERVFKASKSNNFYMGLLLLILFLSLLPVVYTIMSLPPSFDCGPFSGKERMFDVVMETIDLDLPAFMGTLFGYVANPGLVISAVLLMVLAIYYLNSVSEAYKNSNNELKKKMQMARDEEKNRRNNKDSTNQVMKDLEDLLPNRPPTPPSPRENIAEKNQGQGGKSAKVKPGTAGGVHLQKDVSLASANPNARGPVTRAPGPRGPGPLPGQPGAGRGQGPPPRRQ
Protein: Single-stranded DNA-binding protein WHY3, chloroplastic (Protein PLASTID TRANSCRIPTIONALLY ACTIVE 11) (Protein WHIRLY 3) (AtWHY3) (Q66GR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Single-stranded DNA-binding protein that functions in both chloroplasts and nucleus. In chloroplasts, maintains plastid genome stability by preventing break-induced and short homology-dependent illegitimate recombinations. In the nucleus, is recruited to a distal element upstream of the kinesin KP1 to mediate the transcriptional repression of KP1. Can bind double-stranded DNA in vivo.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:15967440}. Nucleus {ECO:0000250}. Note=Can localize to both chloroplast and nucleus. {ECO:0000250}.
Interaction partners:
- DNA polymerase I B, chloroplastic/mitochondrial
- Protein OSB3, chloroplastic/mitochondrial
- DNA repair protein recA homolog 2, mitochondrial
- DNA repair protein recA homolog 3, mitochondrial
- DNA mismatch repair protein MSH1, mitochondrial
- Protein OSB4, chloroplastic
- DNA repair protein recA homolog 1, chloroplastic
- Protein OSB2, chloroplastic
- Protein kinase superfamily protein
- Protein OSB1, mitochondrial
Sequence:
MSQLLSSPPMAVFSKTFINHKFSDARFLSSHSILTSGGFAGKIIPLKPTARLKLTVKSRQSDYFEKQRFGDSSSSQNAEVSSPRFYVGHSIYKGKAALTIEPRAPEFVALESGAFKLTKEGFLLLQFAPAAGVRQYDWSRKQVFSLSVTEIGNLVSLGPRESCEFFHDPFKGKGSDEGKVRKVLKVEPLPDGSGRFFNLSVQNKLLNVDESVYIPITKAEFAVLISAFNFVLPHLIGWSAFANSIKPEDSNRLNNASPKYGGDYEWSR
Protein: FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (PPIase) (EC 5.2.1.8) (Metallochaperone SlyD) (Q9CKP2)
Organism: Pasteurella multocida (strain Pm70)
Function: Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MKIAKNVVVSIAYQVRTEDGVLVDEAPVNQPLEYLQGHNNLVIGLENALEGKAVGDKFEVRVKPEEAYGEYNENMVQRVPKDVFQGVDELVVGMRFIADTDIGPLPVVITEVAENDVVVDGNHMLAGQELLFSVEVVATREATLEEIAHGHIHQEGGCCGGHHHDSDEEGHGCGCGSHHHHEHEHHAHDGCCGNGGCKH
Protein: Glycosylated lysosomal membrane protein (Lysosomal protein NCU-G1) (Q8WWB7)
Organism: Homo sapiens (Human)
Function: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:19556463}; Single-pass type I membrane protein {ECO:0000255}; Lumenal side {ECO:0000305}.
Interaction partners:
- Phorbol-12-myristate-13-acetate-induced protein 1
Sequence:
MRGSVECTWGWGHCAPSPLLLWTLLLFAAPFGLLGEKTRQVSLEVIPNWLGPLQNLLHIRAVGTNSTLHYVWSSLGPLAVVMVATNTPHSTLSVNWSLLLSPEPDGGLMVLPKDSIQFSSALVFTRLLEFDSTNVSDTAAKPLGRPYPPYSLADFSWNNITDSLDPATLSATFQGHPMNDPTRTFANGSLAFRVQAFSRSSRPAQPPRLLHTADTCQLEVALIGASPRGNRSLFGLEVATLGQGPDCPSMQEQHSIDDEYAPAVFQLDQLLWGSLPSGFAQWRPVAYSQKPGGRESALPCQASPLHPALAYSLPQSPIVRAFFGSQNNFCAFNLTFGASTGPGYWDQHYLSWSMLLGVGFPPVDGLSPLVLGIMAVALGAPGLMLLGGGLVLLLHHKKYSEYQSIN