wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor SOX-10 (cSOX10) (Q9W757)
Organism: Gallus gallus (Chicken)
Function: Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P56693}. Nucleus {ECO:0000250|UniProtKB:P56693}.
Interaction partners:
- Paired box 3
- Forkhead box protein D3
- Oligodendrocyte transcription factor 2
- Glial fibrillary acidic protein
- G_PROTEIN_RECEP_F1_2 domain-containing protein
- Uncharacterized protein.
- TF_AP-2 domain-containing protein.
- Paired like homeobox 2B
- Platelet-derived growth factor receptor alpha
- Myelin proteolipid protein
Sequence:
MADDQDLSEVEMSPVGSEDHHCLSPGPSMASDNSSHLASSGNGEMGKVKKEQQDSEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGSNKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKATQGEGEGQVEGEAGGAASIQAHYKNAHLDHRHPGEGSPMSDGHPEHSSGQSHGPPTPPTTPKTELQAGKADSKREGRSLGEGGKPHIDFGNVDIGEISHEVMSNMETFDVNEFDQYLPPNGHAGHPGHVGGYAAAAGYGLGSALAAASGHSAWISKQHGVSLSATTSPVVDSKAQVKTEGSAPGGHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYPDHQPSGPYYSHSSQASGLYSAFSYMGPSQRPLYTAISDPAPSVPQSHSPTHWEQPVYTTLSRP
Protein: Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (EC 2.7.7.12) (UDP-glucose--hexose-1-phosphate uridylyltransferase) (Q03249)
Organism: Mus musculus (Mouse)
Function: Plays an important role in galactose metabolism.
Interaction partners:
- Galactokinase
- UDP-glucose 4-epimerase
- UTP--glucose-1-phosphate uridylyltransferase
- N-acetylgalactosamine kinase
- Beta-1,4-galactosyltransferase 2
- Alpha-lactalbumin
- Beta-1,4-galactosyltransferase 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- UDP-glucose 6-dehydrogenase
Sequence:
MSHSGADPEQRQQASEADAMAATFRASEHQHIRYNPLQDEWVLVSAHRMKRPWQGQVEPQLLKTVPRHDPLNPLCPGATRANGEVNPHYDGTFLFDNDFPALQPDAPDPGPSDHPLFRAEAARGVCKVMCFHPWSDVTLPLMSVPEIRAVIDAWASVTEELGAQYPWVQIFENKGAMMGCSNPHPHCQVWASSFLPDIAQREERSQQTYHSQHGKPLLLEYGHQELLRKERLVLTSEHWIVLVPFWAVWPFQTLLLPRRHVRRLPELNPAERDDLASIMKKLLTKYDNLFETSFPYSMGWHGAPTGLKTGATCDHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLTPEQAAERLRALPEVHYCLAQKDKETAAIA
Protein: Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase (DRAP deaminase) (EC 3.5.4.26) (Riboflavin-specific deaminase); 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) (HTP reductase)] (P9WPH1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
Interaction partners:
- Riboflavin synthase
- 3,4-dihydroxy-2-butanone-4-phosphate synthase
- Riboflavin biosynthesis protein RibBA
- 6,7-dimethyl-8-ribityllumazine synthase
- Putative methyltransferase Rv1407
- Riboflavin biosynthesis protein
- Dihydrofolate synthase/folylpolyglutamate synthase
- Possible carboxylase
- Ribulose-phosphate 3-epimerase
- Methionyl-tRNA formyltransferase
Sequence:
MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIVGAGGTEPAGGDHAEVVALRRAGGLAAGAIVVVTMEPCNHYGKTPPCVNALIEARVGTVVYAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKYATSIDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAPQQPLRVVVGKRDIPPEARVLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAFLRAGAINRILAYVAPILLGGPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLLSLVAR
Protein: BarH-like 1 homeobox protein (Q9BZE3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor ATOH1
- LIM/homeobox protein Lhx9
Sequence:
MEGSNGFGIDSILSHRAGSPALPKGDPLLGDCRSPLELSPRSESSSDCSSPASPGRDCLETGTPRPGGASGPGLDSHLQPGQLSAPAQSRTVTSSFLIRDILADCKPLAACAPYSSSGQPAAPEPGGRLAAKAAEDFRDKLDKSGSNASSDSEYKVKEEGDREISSSRDSPPVRLKKPRKARTAFTDHQLAQLERSFERQKYLSVQDRMELAASLNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYPQSLVSNLDPGAALYLYRGPSAPPPALQRPLVPRILIHGLQGASEPPPPLPPLAGVLPRAAQPR
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A2R8YF43)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
Protein: DNA-binding protein MNB1B (HMG1-like protein) (P27347)
Organism: Zea mays (Maize)
Function: Recognizes an AAGG motif at the MNF1-binding site.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Actin-related protein 4
- Actin-related protein 5
- General transcription factor IIH subunit
- Putative RNA polymerase II transcription factor B subunit 1-1
- Actin-related protein 9
- Actin-related protein 9
- Thiamine thiazole synthase 2, chloroplastic
- General transcription and DNA repair factor IIH subunit TFB4
- Yabby9 protein
- Dof zinc finger protein MNB1A
Sequence:
MKGAKSKGAAKADAKLAVKSKGAEKPAKGRKGKAGKDPNKPKRAPSAFFVFMEEFRKEFKEKNPKNKSVAAVGKAAGDRWKSLSESDKAPYVAKANKLKLEYNKAIAAYNKGESTAAKKAPAKEEEEEDEEESDKSKSEVNDEDDEEGSEEDEDDDE
Protein: KH domain containing, RNA binding, signal transduction associated 1 (KH domain-containing, RNA-binding, signal transduction-associated 1a) (KH domain-containing, RNA-binding, signal transduction-associated protein 1a isoform 1) (Q6NW56)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Ubiquinol-cytochrome c reductase core protein 2a
- U2AF homology motif
- tRNA wybutosine-synthesizing protein 3 homolog
- Pre-mRNA-processing factor 40 homolog A
- Peptidylprolyl isomerase G
- KH-type-splicing regulatory protein.
- Heterogeneous nuclear ribonucleoprotein Q
- KH homology domain-containing protein 4
Sequence:
MDPNSNKRKNNAGDGKYLPELLAEKDSLDSSFTHAMKLLSAEIERVQKGEPKKDSELYLDLFASKSVRVKERVLIPVKQYPRFNFVGKILGPQGSTIKRLQEDTGAKISVLGKGSMRDKNKEEELRKGGDPKYAHLGMELHVHIEVFAPIPDCYLRMAHAMDEVKKFLMPVEGMDEMHPDAFMDPGFLNGAQDMSGHGRGMPGRGRGGPPPMGARGRGMPPRGAPRGGAPRGGPGRGAAARGAPAGRGGPQPPTPTRGGAASRSRPPTQAARMTPAAGLSHQQAKPETYGEYAYEEPYAEASYEGYESYYSQQPAQPDTEYYDYGHGEAQESYESYTEDDWEGGAWGGAGGKAPTARQGKSFREHPYGRY
Protein: Coatomer subunit beta (Beta-coat protein) (Beta-COP) (Q9UUF7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Interaction partners:
- Probable coatomer subunit gamma
- Coatomer subunit delta
- Probable coatomer subunit beta'
- Probable coatomer subunit zeta
- Putative coatomer subunit alpha
- Probable coatomer subunit epsilon
- ADP-ribosylation factor 1
- ADP-ribosylation factor GTPase-activating protein glo3
- Probable clathrin heavy chain
- AP-1 complex subunit gamma-1
Sequence:
MSCWTLVQQDFLEAPSVDALKTSLESKNDYVKISAMKTILRVVINGDSLPSILMHVIRFVMPSRNKELKKLLYYYWEVCPKYNNDGTMKQEMILACNSFRNDLQHPNEFIRGATLRFLCKLKEPELLDPLIPTVRQCLEHRHAYVRKNAILAVFSIYQVSNHLIPDAASLAEDFLAAESEGTCKRNALIVLFTIDPEKAKAWLLANFEQIPSLNASSLLVIIEFIRKVVLTKADGLEKLRFQSLLVSLTATNNSSVVFEAATSVINVFPDAESLKLAASRLLALADREADNNAKLIMLDRISQLAARDKSILEDLITDVIPFLSSSDFDVCEKAISIIMGLVSSRNVEDILNHFQKELTKSNGETEKDDGRRRALTKAIHSCAINFPHTAATAIQYLLSHISDFQSKSASSVLSFIKEVMEKFPDLRSSNITKLLLSLKELRAGKIFRGVIWIAGEYCLTEDDIRVAWKSIRASLGEVPILASEEQLLKDVSNVPEDDLLIDISAPASTSRKVLPDGTYATESAVTSEALSAARLEAVKASKKPPLRTQILSGDYYLAAVLASALTKLVMRFARLSFDKERLNALKAEACLIMTSIIRVGQSKFVKYTIDDDSVERIMNCIRAIYSFEELPEFQTVFLDDMRKAFSSLVAQSDKRQKEADLLVNGSDAVQADELLNIRQFQRVIEEKQDLNFESDIIQATNDGMVVEDLASKLDHIVQLAGFTDPVYCEAYVKIQQFDIILDILLVNRTDTTLQNLSVDLATLGDLKVVERPPPMNLGPHAFKSVQATVKVSSTESAVIFGNIVYGGKASDEDKIVVLNGIPVNIIDYIKPAFIPESQFRSMWTEFEWENKVDISSNEDISLYDFLHKIMKKTNMNCLTPDASLRGDCGFLSANLYACSIFGEDALMSLSVEKSVSGPISGHVRIRSKTQGIALSLGAFV
Protein: Cellulose synthase-like protein E1 (AtCslE1) (EC 2.4.1.-) (Q8VZK9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Sucrase-like protein
- Large ribosomal subunit protein P2x
- Dihydroxy-acid dehydratase, chloroplastic
- Glucomannan 4-beta-mannosyltransferase 7
- Probable glucomannan 4-beta-mannosyltransferase 1
- AT4g23680/F9D16_150
- Twinkle homolog protein, chloroplastic/mitochondrial
- FCS-Like Zinc finger 5
- AT3g20100/MAL21_14
Sequence:
MVNKDDRIRPVHEADGEPLFETRRRTGRVIAYRFFSASVFVCICLIWFYRIGEIGDNRTVLDRLIWFVMFIVEIWFGLYWVVTQSSRWNPVWRFPFSDRLSRRYGSDLPRLDVFVCTADPVIEPPLLVVNTVLSVTALDYPPEKLAVYLSDDGGSELTFYALTEAAEFAKTWVPFCKKFNVEPTSPAAYLSSKANCLDSAAEEVAKLYREMAARIETAARLGRIPEEARVKYGDGFSQWDADATRRNHGTILQVLVDGREGNTIAIPTLVYLSREKRPQHHHNFKAGAMNALLRVSSKITCGKIILNLDCDMYANNSKSTRDALCILLDEKEGKEIAFVQFPQCFDNVTRNDLYGSMMRVGIDVEFLGLDGNGGPLYIGTGCFHRRDVICGRKYGEEEEEEESERIHENLEPEMIKALASCTYEENTQWGKEMGVKYGCPVEDVITGLTIQCRGWKSAYLNPEKQAFLGVAPTNLHQMLVQQRRWSEGDFQIMLSKYSPVWYGKGKISLGLILGYCCYCLWAPSSLPVLIYSVLTSLCLFKGIPLFPKVSSSWFIPFGYVTVAATAYSLAEFLWCGGTFRGWWNEQRMWLYRRTSSFLFGFMDTIKKLLGVSESAFVITAKVAEEEAAERYKEEVMEFGVESPMFLVLGTLGMLNLFCFAAAVARLVSGDGGDLKTMGMQFVITGVLVVINWPLYKGMLLRQDKGKMPMSVTVKSVVLALSACTCLAFL
Protein: GM14559p (SD08285p) (Q8T3U3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIGTVPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPKFIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIKAVNFKDASGGKVTKAAEKATKGKK
Protein: Indole-3-acetic acid-amido synthetase GH3.3 (EC 6.3.2.-) (Auxin-responsive GH3-like protein 3) (AtGH3-3) (O22190)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin. Strongly reactive with Glu, Gln, Trp, Asp, Ala, Leu, Phe, Gly, Tyr, Met, Ile and Val. Little or no product formation with His, Ser, Thr, Arg, Lys, or Cys. Also active on pyruvic and butyric acid analogs of IAA, PAA and the synthetic auxin naphthaleneacetic acid (NAA). The two chlorinated synthetic auxin herbicides 2,4-D and 3,6-dichloro-o-anisic acid (dicamba) cannot be used as substrates.
Interaction partners:
- Auxin response factor 8
- Auxin response factor 17
- Auxin transporter protein 1
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin-responsive protein IAA19
- Auxin-responsive protein IAA5
- Auxin-responsive protein IAA2
- Auxin-responsive protein IAA1
- Auxin response factor 6
- Auxin-responsive protein IAA3
Sequence:
MTVDSALRSPMMHSPSTKDVKALRFIEEMTRNVDFVQKKVIREILSRNSDTEYLKRFGLKGFTDRKTFKTKVPVVIYDDLKPEIQRIANGDRSMILSSYPITEFLTSSGTSAGERKLMPTIDEDMDRRQLLYSLLMPVMNLYVPGLDKGKALYFLFVKTESKTPGGLPARPVLTSYYKSEQFKRRPNDPYNVYTSPNEAILCPDSSQSMYTQMLCGLLMRHEVLRLGAVFASGLLRAIGFLQTNWKELADDISTGTLSSRISDPAIKESMSKILTKPDQELADFITSVCGQDNSWEGIITKIWPNTKYLDVIVTGAMAQYIPMLEYYSGGLPMACTMYASSESYFGINLKPMCKPSEVSYTIMPNMAYFEFLPHHEVPTEKSELVELADVEVGKEYELVITTYAGLNRYRVGDILQVTGFYNSAPQFKFVRRKNVLLSIESDKTDEAELQSAVENASLLLGEQGTRVIEYTSYAETKTIPGHYVIYWELLVKDQTNPPNDEVMARCCLEMEESLNSVYRQSRVADKSIGPLEIRVVKNGTFEELMDYAISRGASINQYKVPRCVSFTPIMELLDSRVVSTHFSPALPHWSPERRR
Protein: Glutamyl-tRNA reductase 1, chloroplastic (GluTR) (EC 1.2.1.70) (P42804)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). Probably involved in the tetrapyrrole synthesis required for the chlorophyll biosynthesis.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:22180625, ECO:0000269|PubMed:22212719, ECO:0000269|PubMed:7908550}.
Interaction partners:
- Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic
- Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic
- Glutamate--tRNA ligase, cytoplasmic
- Glutamate--tRNA ligase, chloroplastic/mitochondrial
- Glutamyl-tRNA reductase-binding protein, chloroplastic
- Porphobilinogen deaminase, chloroplastic
- Protein FLUORESCENT IN BLUE LIGHT
- Magnesium-chelatase subunit ChlH, chloroplastic
- Chlorophyllide a oxygenase, chloroplastic
- Magnesium protoporphyrin IX methyltransferase, chloroplastic
Sequence:
MAVSSAFVGCPKLETLLNHHNLSPSSSSSSSVSQTPLGLNGVRVLPKNNRTRRGLIQKARCELSASSDSASNAASISALEQLKNSAADRYTKERSSIVVIGLSIHTAPVEMREKLAIPEAEWPRAIAELCGLNHIEEAAVLSTCNRMEIYVLALSQHRGVKEVTEWMSKTSGIPVSEICQHRFLLYNKDATQHIFEVSAGLDSLVLGEGQILAQVKQVVKVGQGVNGFGRNISGLFKHAITVGKRVRTETNIASGAVSVSSAAVELALMKLPQSSNVSARMCVIGAGKMGKLVIKHLMAKGCTKVVVVNRSEERVSAIREEMPGIEIIYRPLDEMLACASEADVVFTSTASETPLFLKEHVENLPQASPEVGGLRHFVDISVPRNVGSCVGEVETARVYNVDDLKEVVAANKEDRMRKAMEAQTIITEESTQFEAWRDSLETVPTIKKLRAYAERIRVAELEKCMSKMGDDINKKTTRAVDDLSRGIVNRFLHGPMQHLRCDGSDSRTLSETLENMHALNRMYGLEKDILEEKLKAMAEQQQK
Protein: RNA-binding protein Musashi homolog 2 (Musashi-2) (Q920Q6)
Organism: Mus musculus (Mouse)
Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11588182}. Note=Associated with polysomes.
Interaction partners:
- DAZ-associated protein 1
- RNA-binding protein Musashi homolog 1
- Protein numb homolog
- Numb-like protein
- Zinc finger CCCH domain-containing protein 14
- Transcription factor SOX-2
Sequence:
MEANGSPGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH
Protein: 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Heat-responsive protein 12) (Reactive intermediate imine deaminase A homolog) (Translation inhibitor L-PSP ribonuclease) (P52760)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P52758}. Nucleus {ECO:0000250|UniProtKB:P52758}. Peroxisome {ECO:0000250|UniProtKB:P52759}. Mitochondrion {ECO:0000250|UniProtKB:P52759}. Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear. {ECO:0000250|UniProtKB:P52758}.
Interaction partners:
- YTH domain-containing family protein 2
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 4
Sequence:
MSSIIRKVISTTKAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQLVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLADMNDFGTVNEIYKTYFQGSLPARAAYQVAALPRGSRVEIEAIAVQGPFIKA
Protein: V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (Vacuolar proton pump subunit G 2) (Q0VCV6)
Organism: Bos taurus (Bovine)
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Subcellular location: Melanosome {ECO:0000250|UniProtKB:O95670}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32764564}; Peripheral membrane protein {ECO:0000305}. Note=Highly enriched in late-stage melanosomes. {ECO:0000250|UniProtKB:O95670}.
Interaction partners:
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase subunit B, brain isoform
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit E 1
- V-type proton ATPase subunit D
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit e 2
- V-type proton ATPase subunit F
- V-type proton ATPase subunit H
Sequence:
MASQSQGIQQLLQAEKRAAEKVADARKRKARRLKQAKEEAQMEVDQYRREREQEFQSKQQAAMGSQGNLSAEVEQATRRQVQGMQSSQQRNRERVLAQLLGMVCDVRPQVHPNYRIAA
Protein: Cystine lyase CORI3 (EC 4.4.1.35) (Protein CORONATINE INDUCED 3) (Protein JASMONATE RESPONSIVE 2) (Q9SUR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses cystine lyase activity in vitro. Does not possess tyrosine aminotransferase, alanine aminotransferase, aspartate aminotransferase and tryptophan aminotransferase activities.
Interaction partners:
- Cystathionine beta-lyase, chloroplastic
- Lipoxygenase 2, chloroplastic
- L-ornithine N5-acetyltransferase NATA1
- Vegetative storage protein 2
- Vegetative storage protein 1
- Defensin-like protein 16
- Protein TIFY 7
- 4-hydroxyphenylpyruvate dioxygenase
- Serine-type endopeptidase inhibitor
Sequence:
MATLKCIDWQFSGSEAAKDAAAASLGSYTSALYALCDPHGKPILPPRNEILETSNTAEKAVVKAVLYGSGNAYAPSLGLAAAKSAVAEYLNQGLPKKLTADDVFMTLGCKQAIELAVDILAKPKANVLLPSPGFPWDLVRSIYKNLEVRHYNFLPEKNFEIDFDSVRALVDENTFAIFIINPHNPNGNTYSEAHLKQLAELAKELKIMVVSDEVFRWTLFGSNPFVPMGKFSSIVPVVTLGSISKGWKVPGWRTGWLTLHDLDGVFRNTKVLQAAQDFLQINNNPPTVIQAAIPDILEKTPQEFFDKRQSFLKDKVEFGYSKLKYIPSLTCYMKPEACTFLWTELDLSSFVDIEDDQDFCNKLAKEENLVVLPGIAFSQKNWLRHSIDMETPVLEDALERLKSFCDRHSNKKAPLKDVNGVK
Protein: Adenosyl-chloride synthase (EC 2.5.1.94) (5'-chloro-5'-deoxyadenosine synthase) (Chlorinase SalL) (A4X3Q0)
Organism: Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / JCM 13857 / NBRC 105044 / CNB-440)
Function: Involved in the biosynthesis of the proteosome inhibitor salinosporamide A (SalA). Catalyzes the halogenation of S-adenosyl-L-methionine (SAM) with chloride to generate 5'-chloro-5'-deoxyadenosine (5'-CIDA) and L-methionine. It can also use bromide and iodide, producing halogenated 5'-deoxyadenosine (5'-XDA) and L-methionine, however no halogenase activity is detected in the presence of fluoride.
Interaction partners:
Sequence:
MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVWTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG
Protein: Phosphoglucomutase (PGM) (EC 5.4.2.2) (Glucose phosphomutase) (P36938)
Organism: Escherichia coli (strain K12)
Function: This enzyme participates in both the breakdown and synthesis of glucose.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21778229}.
Interaction partners:
- Glucose-6-phosphate isomerase
- Glycogen phosphorylase
- Maltodextrin phosphorylase
- 1,4-alpha-glucan branching enzyme GlgB
- Glucose-1-phosphate adenylyltransferase
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogen debranching enzyme
- Glucose-6-phosphate 1-dehydrogenase
- Glucokinase
- Transketolase 1
Sequence:
MAIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPHILAIAQAIAEERAKNGITGPCYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPTPAVSNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPPNGGPADTNVTKVVEDRANALLADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSGIEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLAFANDPDYDRHGIVTPAGLMNPNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVNDLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFDGTPWSTDKDGIIMCLLAAEITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITARLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVSEVLKNA
Protein: Zinc transporter SLC39A7 (A0A1I7U4N8)
Organism: Caenorhabditis tropicalis
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Zinc transporter ZIP9
- BZIP domain-containing protein
- Transmembrane 9 superfamily member
- Post-GPI attachment to proteins factor 2
Sequence:
MWVKSCIFLSFLAIAAYGQAHLKYTKEMNDPEFVDQHVHHQGHGHAHGGHGHAHDADGGCPYAKAAAEEAAAAAAHGHAHDHGHDHGHAHDHHGHSHDAEDVHDHGHAHEHHGHSHGAKAAKQVASEYKYTGFLSFLNDAKTRLWVYGISATLLISAAPCFILMFIPIQANTSESGPLLKVLLAFGSGGLLGDAFLHLIPHATPAGDGHGHSHSHGHSHGGGHSHGAHDMSVGGWVLAGIIAFLTVEKLVRILRGGEGHSHGHSHGGEKKESKKEDKKEESKDCKKVEKDEQTIKVTAYLNLAADFAHNFTDGLAIGASFIAGTTVGVVTMITVLVHEVPHEIGDFAILIQSGYSKKKAMLIQLVTALGALSGCVISLLATDADALADAAASSWVLPFTAGGFIYIATVSVIPELLENSSFFQTIKEIFALLTGIFLMYLIAIYE
Protein: Polyprenal reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 2-like) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3) (Q9WUP4)
Organism: Mus musculus (Mouse)
Function: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5RJM1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5RJM1}.
Interaction partners:
- Dolichol kinase
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
- 17-beta-hydroxysteroid dehydrogenase type 3
- 17-beta-hydroxysteroid dehydrogenase type 6
- Estradiol 17-beta-dehydrogenase 2
- Steroid 17-alpha-hydroxylase/17,20 lyase
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
- steroid 11beta-monooxygenase
Sequence:
MAGWAGFELSALNPLRTLWLALAAAFLFALLLQLAPARLLPSCALFQDLLRYGKTKQSGSRRPAVCRAFDVPKRYFSHFYVISVVWNGSLLWLLSQSLFLGAPFPNWLSALLRTLGATQFQALEMESKASRMPAAELALSAFLVLVFLWVHSLRRLFECFYVSVFSNAAIHVVQYCFGLVYYVLVGLTVLSQVPMDDKNVYVLGKNLLIQARWFHILGMVMFFWSSAHQYKCHVILSNLRRNKKGVVIHCQHRIPFGDWFEYVSSANYLAELMIYISMAVTFGLHNLTWWLVVTYVFSSQALSAFFNHKFYRSTFVSYPKHRKAFLPFLF