wanglab/gogpt-training-data huggingface dataset:
Protein: Catalase (EC 1.11.1.6) (Q9PT92)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.
Subcellular location: Peroxisome matrix {ECO:0000250|UniProtKB:P04040}.
Interaction partners:
- Superoxide dismutase
- (S)-2-hydroxy-acid oxidase
- Hydroxyacid oxidase
- 3-hydroxyanthranilate 3,4-dioxygenase
- Regucalcin
- Superoxide dismutase
- Superoxide dismutase
- Superoxide dismutase 3, extracellular a.
- Trehalase.
- Ribonuclease P 14 subunit
Sequence:
MADDREKSTDQMKLWKEGRGSQRPDVLTTGAGVPIGDKLNAMTAGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYSKAKVFEHVGKTTPIVVRFSTVAGEAGSPDTVRDPRGFAVKFYTDEGNWDLTGNNTPTFFIRDTLLSPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGYRHMNGYGSHTFKLVNAQGQPVYCKFHYKTNQGIKNIPVEEADRLAATDPDYSIRDLYNAIANGNFPSWTFYIQVMTFEQAENWKWNPFDLTKVWSHKEFPLIPVGRFVLNRNPVNYFAEVEQLAFDPSNMPPGIEPSPDKMLQGRLFSYPDTHRHRLGANYLQLPVNCPYRTRVANYQRDGPMCMHDNQGGAPNYYPNSFSAPDVQPRFLESKCKVSPDVARYNSADDDNVTQVRTFFTQVLNEAERERLCQNMAGHLKGAQLFIQKRMVQNLMAVHSDYGNRVQALLDKHNAEGKKNTVHVYSRGGASAVAAASKM
Protein: Otogelin-like protein (Q3ZCN5)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Stereocilin
- Otogelin
- Ubiquitin-like protein FUBI
- Cell adhesion molecule CEACAM16
- Beta-tectorin
Sequence:
MNIVRKLNLMIPWSIFLLHVLLFSLQEYICASSILMGTSKNGFNENRQKRALLAAQFEATSPRYFFHDAINWGESKIKGSCPYECLNGAFCSKTGTCDCQIFQALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRYTVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEKLADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYTEDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHEYIDPYLYIASCVNDLCKTDDDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDDSFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGLAYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYILVKGTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQGFNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGNIRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAHCDVIHQELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPIDFRTQISFCAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIFHCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPDPELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGMAEHRGKCYVPESCPCIWKDWEYLSGEVIATPCYTCVCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQVFLIKSADDSDISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLENKSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSNDMTTSNNLEVRNARVFGDSWALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDIFASCRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSLDCEYYNEGLGEGPYMLASYGQSGLVLGANMTSRSVFCLPRSSVHTSLFFYFMITPGLFKEKVSSLALVSLESAERPNYFLYVHDNDTLSLELWEANSAFHRRATFFHHQGLWIPGYSAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSSSFSIEEIQAAVPYRKMCEWRYEPCATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPVIPTEPTLMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLNMEWQLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNAALYSMASYILVRIPGEIIVAHIEKCSMNQNGNSLKKLAPSGRISGLCFKKLNVTTPIHKIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIHFGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMRRPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYVALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDCVCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIPIEPDCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVGHSPLSCCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVPLCHDGEFLTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWHCECNCENLIMPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIKYLEEDFCYAIECLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNVSCKFHMENGTSVVYAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEGIVKLYNEGCCKICKREERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNINIESHLRFCKCCRENGVRNLSVPLYCSGNGTEIMYTLQEPIDCTCQWN
Protein: Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) (P48281)
Organism: Mus musculus (Mouse)
Function: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis. Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P11473, ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250|UniProtKB:P11473}. Note=Localizes mainly to the nucleus. Translocated into the nucleus via both ligand-dependent and ligand-independent pathways; ligand-independent nuclear translocation is mediated by IPO4. {ECO:0000250|UniProtKB:P11473}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 1
- Nuclear receptor coactivator 2
- Retinoic acid receptor RXR-alpha
- Nuclear receptor coactivator 1
- 1,25-dihydroxyvitamin D
- Nuclear receptor corepressor 1
- 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
- Nuclear receptor corepressor 2
Sequence:
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPIRADVSTGSYSPRPTLSFSGDSSSNSDLYTPSLDMMEPASFSTMDLNEEGSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTLDDMSWDCGSQDYKYDITDVSRAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS
Protein: KLLA0F05115p (Q6CL77)
Organism: Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Interaction partners:
- Histone H3-like centromeric protein CSE4
- Histone H4
Sequence:
MIKRPSNSKKKANLRRLTGALRDLLGEEEPKKEENLKQITRDGVVYIMSKENRLIPKLSDEEVMERHKKADENMKRVWSQIIQKYESIDNQGDVIDLQTGEVIEDNGHLRNLSNEKSVLHSSLPDGGSVSYKSVLNDIMDIKDSSYNSSVWQDHETNDSETGSESESGLEADGLDEGSGSEADNSNEVYMKKLRPNPESN
Protein: H(+)-transporting two-sector ATPase (EC 7.1.2.2) (A0A060XSR8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Uncharacterized protein
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit F
- V-type proton ATPase subunit F
- V-type proton ATPase subunit D
- V-type proton ATPase subunit
- Vacuolar proton pump subunit B
- V-type proton ATPase subunit E 1
- V-type proton ATPase subunit D
- Vacuolar proton pump subunit B
Sequence:
MDLSKLPKIRDEEKESEFGYVHGVSGPVVTATAMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDINDLTQSIYIPRGVNIGALNRDLKWEFSPVKSLRVGSHITGGDIYGMVFENSLIKHKIMLPPRNRGTVTYVAPPGNYDVSDVVLELEFEGMKEKFTMIQVWPVRQIRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIVYVGCGERGNEMSEVLRDFPELTMEVDGKTESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYTRALDEYYDKHFPEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLLKDDFLQQNGYTPYDRFCPFYKTVGILSNIIAFYDMARHAVETTAQSDNKITWSMIREHLGEILYRLSSMKFKDPVKEGETQIKSDYAQLLEDMQNSFRSLED
Protein: Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (Sm-D autoantigen) (snRNP core protein D1) (P62315)
Organism: Mus musculus (Mouse)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62314}. Nucleus {ECO:0000250|UniProtKB:P62314}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000250|UniProtKB:P62314}.
Interaction partners:
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein-associated protein B
- U1 small nuclear ribonucleoprotein C
- Methylosome subunit pICln
- U1 small nuclear ribonucleoprotein 70 kDa
- Splicing factor 3A subunit 3
Sequence:
MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVSMNTHLKAVKMTLKNREPVQLETLSIRGNNIRYFILPDSLPLDTLLVDVEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR
Protein: Nitric oxide-associated protein 1 (Q9JJG9)
Organism: Mus musculus (Mouse)
Function: Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16380119, ECO:0000269|PubMed:18456285}; Peripheral membrane protein {ECO:0000269|PubMed:16380119, ECO:0000269|PubMed:18456285}; Matrix side {ECO:0000269|PubMed:16380119, ECO:0000269|PubMed:18456285}.
Interaction partners:
- GTPase Era, mitochondrial
- Small ribosomal subunit protein mS27
- GTP-binding protein 4
- Small ribosomal subunit protein mS34
- Dimethyladenosine transferase 1, mitochondrial
- Mitochondrial ribosome-associated GTPase 2
- Mitochondrial assembly of ribosomal large subunit protein 1
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein mS40
Sequence:
MLPARLACGLLCGLRRGPAPAAACYGPARWLLEGKCEVPIRQRASSLGRRVPPSSTATEDYAEGPDTEERFLFPEYVPERTPEEQVRELQELRELQQLQQEKERERLQQREERLQQKLRAGFRTLPVPEFPDASVPPSGIYCSGCGAELHCQHPGLPGYLPEEKFRDAAQAEGGPARTVCQRCWLLVHHGRALRLQVSRDQYLELVSAALRRPGPALVLYMVNLLDLPDALLPDLPKLVGPKQLIVLGNKVDLLPQDAPGYLKRLRKRLWDDCIRAGLVVAPGHQGPQYPAGDEPLEEIKNQNPSSRSRTVVKDVRLISAKTGYGVEEMISALQRSWRYRGDVYLVGTTNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKFPICNPTPYRMFKRQRRLQEDATKAEEDLSEEEQSQLNQLKKHGYIVGRVGRTFSYSREQDEVPFEFDADSLAFDMGSEPVVSVCKSTKQIELTPEDVKDAHWFYDTPGITKESCILNLLTEKEINTVLPTHSIIPRTFVLKPGMVLFLGGIARIDFLQGNQSAWFTVVASNFLPVHITSLDKADALYEKHAGHELLLVPMGGKERMAQFPPLVAEDITLKGGGKFEAVADIKFSSAGWVAVTPYSEGTLHLRGHTPEGTALTVHPPVLPYIVNVKGQRMKKSVAYKTKKPPSLVHNLKKHR
Protein: Ubiquitin fusion degradation protein 1 homolog (UB fusion protein 1) (Ubiquitin fusion-degradation 1-like) (Q9VTF9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway.
Interaction partners:
- Nuclear protein localization protein 4 homolog
- UBX domain-containing protein 7
- Transitional endoplasmic reticulum ATPase TER94
- Phospholipase A2 activator protein, isoform A
- Ubiquitin thioesterase Otu1
- Derlin
- Derlin-1
- Caspar, isoform A
- Ubiquitin conjugation factor E4 B
- Fas-associated factor 2, isoform A
Sequence:
MFHFSGFNMMFPEGRNFHANYKCFSVSMLPGNERTDVEKGGKIIMPPSALDTLTRLNVEYPMLFKLTNVKKSRSSHAGVLEFVADEGKCYLPHWMMENLLLGEGDILNIESVSLPVATFSKFQPHSTDFLDITNPKAVLENALRNFACLTRGDVIAIKYNKKVYELCVLETKPGNAVSIIECDMNVEFEAPVGYKDHSETQASGSGQQGAAGTVGGEIAGATNAILEEVVETFKGSGVRLDGKKKKESQLETPVVKKVLARGVPDYDFQFGLIRFDRNIRPISDRSQEDDAVAGNADASDAESFHGTGFSMKKTRK
Protein: Inner membrane protein YccF (P0AB12)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Inner membrane protein YccS
- DNA-packaging protein NU1 homolog
- DNA helicase IV
- Uncharacterized protein YnfO
Sequence:
MRTVLNILNFVLGGFATTLGWLLATLVSIVLIFTLPLTRSCWEITKLSLVPYGNEAIHVDELNPAGKNVLLNTGGTVLNIFWLIFFGWWLCLMHIATGIAQCISIIGIPVGIANFKIAAIALWPVGRRVVSVETAQAAREANARRRFE
Protein: Protein kinase, putative (EC 2.7.1.-) (Q385N4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- GP-PDE domain-containing protein
- Cyclin-dependent kinases regulatory subunit
- Serine/threonine-protein kinase, putative
Sequence:
MRVMRHLSKEVETEFNYEISKVKLGSGSSGVVFLARHRVTHELAAVKRLYMRGAPECMKISQQHNSQSDNTNDAHIGGNTLAPASPAKSSSHRMQTSDKNSNPVSGNRSNELCEEKIFSHYTSMKRERALSEDTSPPAAICPPWLPCEYASMKYLGPHPHIVRFLGNCADVNGVSYFAMELMDSDLGKELRAGNASFMEEEAIRPLLYCVSSAIVHLHERGVAHRDIKPSNVLLKFVGDMCPTEEEHGMPNGGDKAFPSSDETKDVGSLRTKHVKASLGDFSTAHFASQSESVGGFCGTLYYKSPEQLLGQAKDFLACDMWALGCTMFEMITGSVAFRGSNDLQVFHQICSQLGTDFQQYPKNTHEQTMFDGISGVSTEFIDLLKGLLALDPCERLRAEEVLRHPFFRSIHQGCGTQETAAELTFPMKIYCAVPPGVVRLARFKPIICAHTTRSGTTKVSGSTETKFGMSQSDSQASRTLHGSDVWPSLISGMPSPLQRSALQPSSDGNEGPLRRFTSTLSCGKKYSVTRRLSVSSSVTMMSNGAVQKPDDFTGISDISASLAALNFSPIPSVAKCCGATSAERSFSPLGTHVSAPGSCHPAPIPLKSSHSFATKSRHPEHQHDSTFASNGYPPPRRVLFDSDTTDGNDVDESVNLMLHNSGDSPKVRKVLFE
Protein: Uncharacterized protein (A0A1D8PD11)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Uncharacterized protein
- ATPase inhibitor
- Ofr1p
- Blood-induced peptide 1
Sequence:
MSALKLAVPEVPKAPELIPVFTFNLKLASDPASIYVNNESDKTLNLATIANGEVKTVPNKLGLELDIHSIYGTDDLNIKNSVSTASLDCKLYGKTANGSGVFIYYPGKVQLDETSVSVFTKKTKEAAIEDSYVTCNPTFYFDDKVEDKYKWVLKENFFARGRFGRDEDDVLYVQYYVYVVR
Protein: NADH-ubiquinone oxidoreductase chain 4 (EC 7.1.1.2) (Q8HCP7)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion membrane {ECO:0000256|RuleBase:RU003297}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003297}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 1
- NADH dehydrogenase subunit 2
- NADH-ubiquinone oxidoreductase chain 4L
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial, putative, expressed
- NADH dehydrogenase iron-sulfur protein 2
- NADH dehydrogenase iron-sulfur protein 3
- NADH dehydrogenase iron-sulfur protein 3
- Cytochrome c oxidase subunit 3
Sequence:
MLEHFCECYFDLSGPILCPVLGSITLLFIPNSSIRLIRLIGLCVSLITFLYPLVPRIQFDPSTAKSQFVESLRWLPYENIHLYMGIDGLSLFFVILTTFLIPICISVGWSGMRSFGKEYITAFLIREFLMIAVSCMLDPLLFYVLSESVPIPMFIIIGVWGSRQRKIKAAYQFFLYTLLGSVFMLLAILLILLQTGTTDLQILLTTEFSERRQILLWIAFFASFAVKVPMVPVHIWLPEAHVEAPTAGSVILAGILLKLGTYGFLRFSIPMFPEATLCFTPFIYTLSAIAIIYTSLTTLRQIDLKKIIAYSSVAHMNLVTIGMFSPNIQGIGGSILLMLSHGLVSSALFLCVGVLYDRHKTRLVRYYGGLVSTMPNFSTIFFFFTLANMSLPGTSSFIGEFLILVGAFQRNSLVATLAALGMILGAAYSLWLYNRVVSGNLKPDFLYKFSDLNGREVSIFLPFLVGVVRMGVHPKVFPDCMHTSVSNLVQHGKFH
Protein: Protein partner of snf, isoform B (A0A0B4K6G3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone H3
- Uncharacterized protein, isoform B
- Histone H3.3A
- Nipped-B protein
- DNA-directed RNA polymerase II subunit RPB1
- IP08861p
- c-Myc-binding protein homolog
- Beta-sarcoglycan
- oxaloacetate tautomerase
- carboxylesterase
Sequence:
MSSSVFTEAPSARPAAAEADSNLVVVYSKSGISFDERAIGNIMEEKSISTISVVRITSPTPSMVDQEEDERLEELANFMETATDSELDSDNGSQSGGDNASEMDEHDEENHNTGDDNNSDSTETEADAPRTRKRVGRKPKAIKKRKRRKPKERPQIVGLRVEQFYADNTADMVVKNALKLAGVSVYKRTAETDALMEVIRNDHNYTPFTSPEQLKNHKRDEKMAMEMQAQSRKIIMQAPGSVKLINAKKRVQAIPLSPVQVKVQRLPVKPHQVQQAAQLQPKVQLIRKPIHSPLPRQKPEIIANNSVNARLRPTRAPVKVIAPPVQEYIEDDDDAQSSDSAEEENADKAYDSEEMSEESDEFQESDNDRDSDMDFDMRHSNRRNPNKRKRVRKVVRQTPSKPMKPLPPPPTTPQHFPELKKRKEVLEPKAPQIGQIIQMPATKSVPAVFALGRGLPSTSFLKIRPTHQSLPVKRPPLPTTPANSNVRRMPAVQLGRIVNSPQEVKEIIINKNMASPKGVFTNLNTLLGEDNNAATKSSPVPLRHRAVMSPSTPRSSYNQQMSPIVVPVPAQAHTPSKGFMPIGVDTAQSHKLPAQIVIETHQSSSELAAENDKQLDLINSIVQDELLKSTLVEQPVVNADEDIPKLVKMLESTAADLDPPPVSLPTNIFPAPEMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQFEAEVVKQVLASTEPGTLDAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIACSTPSRSVAASTPPTSAKVVRGYGRVIYLPPIEAPTTRAKRRAQFPSAPGMAATSSSDAGNLSFGESSLDASINQPLNTSSLSNDSQPGSGPKRPNPREPSMARRSTAPRRSKKLDASQNNDPDASESQEDDDDPNKLWCICRQPHNNRFMICCDLCEDWFHGTCVGVTKAMGTDMENKGIDWKCPKCVKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTLPVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISETLCVVCKRPASTSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQADTVSKVERINVFERKSGRVITGHMAPSAHQFRKWLQENPSFEVLPSGTVQSADAEKRLLKGAPEAATSTSEPAVLGVAKKPPEGPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKTTPTVQAPTPNRIAAGKPEPVRIGIRRSLREQLLARIKEAQAAEENSGQPTTQWPTVLEVDQFVKNVELEMFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLASQELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLPEENVSEASSMADTKQTSLVSEPSTSTLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQHNEGGEQPGSGEREHRSREKQSRERDEIVPSPLPKKRDENDQSPVPKKTAEKKTEASAYNLVDQILESEKTVEQAANLGKPKPSPKPLPTLPSSLKAPEPMDNYSRYLHGLTTSSLWSGTLKMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRITRVNVWEYIKKLKKSPTKEVVIVNIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFPLGSGDKLPPALQTAEPVPFYEEAQRPNTLLGIIVRCLSKRPADAVPSTPSVPTPVPALSSKVAKRSRSSISYPAQSSPKRKISTHSTSSKDDEFDIDAIIKAPIAKLQKTAPKVVPQPSVPNDADEPYSPGGSDDELVPSAPQRPNDLERQVNEINKQIAAQQMEIAGLLKVEPTGSASSSNVLAAISIPANLSKILASIKDKTNLPSSADDGDEEYNPEDDITATSSFASKKPRSKGRLAHLSEAELLSMVPDNLAGVIPRSSRTRHQLAQSPLTPTPLPPPPPPPGV
Protein: Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36) (Q91XW8)
Organism: Mus musculus (Mouse)
Function: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12764197, ECO:0000269|PubMed:22902560}. Nucleus {ECO:0000269|PubMed:12764197}. Chromosome {ECO:0000269|PubMed:12764197}. Note=Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (synaptonemal complex). {ECO:0000269|PubMed:12764197, ECO:0000269|PubMed:22902560}.
Interaction partners:
- Heat shock protein HSP 90-alpha
- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
- RNA helicase Mov10l1
- ATP-dependent RNA helicase TDRD9
- Heat shock-related 70 kDa protein 2
- Tudor and KH domain-containing protein
- SUMO-conjugating enzyme UBC9
- Death-inducer obliterator 1
- Protein maelstrom homolog
- Putative ATP-dependent RNA helicase TDRD12
Sequence:
MGGSTRDPGALEGAGILGQSPYERLSQRMLDISGDRGVLKDIIREGTGDTVTPDASVLVKYSGYLEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRKGELARFLFKPAYAYGTLGCPPLIPPNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKVRYKRALLLLHRRLATCEEQHLVEPAVLLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKALFRCGQACLLLTEYERARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGSRSSVGGN
Protein: RNA polymerase II nuclear localization protein IWR1 (Interacting with RNA polymerase II protein 1) (Q07532)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Directs RNA polymerase II nuclear import. Binds RNA polymerase II in the active center cleft between the two largest subunits in the cytoplasm. Then uses an N-terminal bipartite nuclear localization signal that may be recognized by karyopherin alpha to direct the polymerase II complex nuclear import. In the nucleus, is displaced from polymerase II complex by transcription initiation factors and nucleic acids, enabling its export and recycling.
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB2
- GPN-loop GTPase 2
- DNA-directed RNA polymerase II subunit RPB9
- GPN-loop GTPase 1
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
Sequence:
MSTISTTTAPEFIRVKRRRDEDSVQALLIDEGKRVKKQKFIFKLSKTVSSESYQSEQESSTPLLKLAHEDHRHFVLEQRKKSRRDSDDEKSQQRLAAEGSTVDDDGLPPEINQMVNDYLKLNKGVEKTERKKPSRKYFTGDSAKIASLPSLDYVFDIYHLEKIHDDEVARYNNEKNIGFVKIIEHIDLALDEESDPNEARSDDEDSNDENYYQNDYPEDEDDDRSILFGSEGEDIAALGEEIVIGVNKSRFSSWNDDKIQGSNGYHDVEEEYGDLFNRLGGKSDVLKSINSSNFIDLDGQEGEIEISDNEDDSDEGDDIEYPRNEFFPTDVDDPLAHHRDRIFHQLQKKINRS
Protein: 2-amino-3-ketobutyrate coenzyme A ligase, putative (EC 2.3.1.29) (Q57YK7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Glycine cleavage system P protein
- L-threonine 3-dehydrogenase, mitochondrial
- HotDog ACOT-type domain-containing protein
Sequence:
MFRTVPRYVSSMLREAAAAQLAAIKEAGTYKVERVITSKQSSTINVSTAATPVLNFCANNYLGLADHPEVIQAAKDALDSHGYGLASVRFICGTTDIHKKLEQTMTEFLGMEDTILYPSCFDANAGVFEALLTSEDAIISDALNHASIIDGVRLCKAERHRYAHLDMKELETALQKTQHNRIRLIVTDGVFSMDGDVAPLDKIVQLAEKYNANVMVDDSHASGFMGPGGRGTPALFGVIDKVDILNTTLGKALGGASGGLSSGCKEIVDLQRQKGRPYLFSNTIAPAAVGGTLKVMELLQTTSSARKQLQDNTHLFRTEMKKAGFTLSGHEECPIAPVMLYEARIAAEFAAKMMAEGIYVTAFSYPVVPKGQARIRVQLSAAHTTEDVKLAVDAFTKIKKELNV
Protein: Zinc finger CCCH domain-containing protein 40 (AtC3H40) (Q93XW7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSGSSMYKTKLCILFNKTGDCSRPNCTFAHGNAELRRPGESSFTGRRHNMDSDLRDRRHNMDSDLRDRLGRQFSPERRPSLDRSGRRVQRFSGHDNSMPFENRRDKDYRENRRFDERRDYAGGLKVGNRIEDRAEDGRNKFHGYNNVLEEQLKDVEMDVKMLTDDKLRLEASVERKAHEVDILTSRIQELETQLDREKDECRRITSSSKKFVKEYNRFLRAQDDLKRSEARLQKLGNQLSTYLAGSEGNNRDVGLDIVSDEETNGRNLRTACDPHNELQNTSSLSRKKHYVDQYTTKEPVEDGLIGRGEEEKVENEKKRPPCWNMLSSKSYSEEESGAWNDEDTINRSSSKEDNWKRRRFSIGTSATDKVILSTSMAAREFDDVAESEEENPEAANGSPLISLPPPPPFRDAHVQRDEDDVNGDVMEQKKAYDDDSV
Protein: Paired box protein Pax-4 (O43316)
Organism: Homo sapiens (Human)
Function: Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.
Subcellular location: Nucleus.
Interaction partners:
- Neurogenin-3
- Neurogenic differentiation factor 1
- Insulin
- Hepatocyte nuclear factor 1-alpha
- Homeobox protein Nkx-2.2
- Insulin gene enhancer protein ISL-1
- Pro-glucagon
- Krueppel-like factor 11
- Solute carrier family 2, facilitated glucose transporter member 2
- ATP-binding cassette sub-family C member 8
Sequence:
MHQDGISSMNQLGGLFVNGRPLPLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLRALQEDQGLPCTRLRSPAVLAPAVLTPHSGSETPRGTHPGTGHRNRTIFSPSQAEALEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGLTVPRVAPGIISAQQSPGSVPTAALPALEPLGPSCYQLCWATAPERCLSDTPPKACLKPCWDCGSFLLPVIAPSCVDVAWPCLDASLAHHLIGGAGKATPTHFSHWP
Protein: PslI (Q9I1N0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- PslJ
- PslH
- PslF
- PslE
- PslD
- PslG
- dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase
- Alginate biosynthesis protein AlgA
- PslA
- PslL
Sequence:
MRIGLDYRTVGSSPHSGISRQVYAMEQALESLPGTQVTRFTVAPLDDPLRQRAVCPPWGCPRTAMHQPHQRLRFEAGFLPRALREQDIDLYISTFNMGLPLPPRPPGVRYALLIHDLFQITLKNYHANRLKALVYRVSDYLSIAYALRVADRVWTPSQYSADEAVRLFPGVAGKVRVLPNQVDGFAGEPADLSARGLPPRYWLLVGTRELRKNVPWFVSAWTRARAQAPGVPPLVLVGSLDHLPEEQRGLPGLHALGGLDDAELHALYRQAERLWQPSYAEGFGLPVVEALSVGTPVAVASGTSLDEVTPPSAPRFSPSDGAALERLMLRLADAPREASAEELIAWAARFNREAYRQRLAALIEELS
Protein: Tachykinin-like peptide-XIV (P.nigriventer tachykinin peptides XIV) (PnTkP-XIV) (U29-ctenitoxin-Pn1n) (U29-CNTX-Pn1n) (P86311)
Organism: Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Subcellular location: Secreted {ECO:0000269|PubMed:15573368}.
Interaction partners:
Sequence:
QKKDKKDRFYGLF