wanglab/gogpt-training-data huggingface dataset:
Protein: Multidrug transporter EmrE (Efflux-multidrug resistance protein EmrE) (Ethidium resistance protein) (Methyl viologen resistance protein C) (P23895)
Organism: Escherichia coli (strain K12)
Function: Multidrug efflux protein that confers resistance to a wide range of toxic compounds, including ethidium, methyl viologen, acriflavine, tetraphenylphosphonium (TPP(+)), benzalkonium, propidium, dequalinium and the aminoglycoside antibiotics streptomycin and tobramycin. Can also transport the osmoprotectants betaine and choline. The drug efflux is coupled to an influx of protons. Can couple antiport of a drug to either one or two protons, performing both electrogenic and electroneutral transport of a single substrate. Simultaneously binds and cotransports proton and drug.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15044024, ECO:0000269|PubMed:9688273}; Multi-pass membrane protein {ECO:0000269|PubMed:15044024, ECO:0000269|PubMed:17005200, ECO:0000269|PubMed:9688273}. Note=Forms antiparallel homodimers (PubMed:17005200, PubMed:18024586, PubMed:20508091, PubMed:20551331, PubMed:22178925, PubMed:23920359). The topology could be controlled by a single positively charged residue placed in different locations throughout the protein, including the very C terminus (PubMed:20508091). {ECO:0000269|PubMed:17005200, ECO:0000269|PubMed:18024586, ECO:0000269|PubMed:20508091, ECO:0000269|PubMed:20551331, ECO:0000269|PubMed:22178925, ECO:0000269|PubMed:23920359}.
Interaction partners:
- Spermidine export protein MdtJ
- UPF0098 protein YbcL
Sequence:
MNPYIYLGGAILAEVIGTTLMKFSEGFTRLWPSVGTIICYCASFWLLAQTLAYIPTGIAYAIWSGVGIVLISLLSWGFFGQRLDLPAIIGMMLICAGVLIINLLSRSTPH
Protein: Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] (Q8K0E8)
Organism: Mus musculus (Mouse)
Function: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P02675}.
Interaction partners:
- Fibrinogen gamma chain
- Fibrinogen alpha chain
- Prothrombin
- Plasminogen
- Antithrombin-III
- Albumin
- Integrin beta-3
- Alpha-2-antiplasmin
- Vitamin D-binding protein
- Kininogen-1
Sequence:
MRHLWLLLLLCVFSVQTQAADDDYDEPTDSLDARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKATANQKKVERRPPDAGGCLHADTDMGVLCPTGCTLQQTLLNQERPIKSSIAELNNNIQSVSDTSSVTFQYLTLLKDMWKKKQAQVKENENVINEYSSILEDQRLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEASKYQVSVNKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPFFPQQ
Protein: Musashi, isoform H (A0A0B4KGY9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MENAAAAAAAAAAGLIDPHHNRDLHQALVASIANNSVAAIGGGLTTAAVLKSAAQQSQQAVQQNQNAVVVTPGLEQPKQEPAQQAALALLKENVNASAGAGQNNGQAAMGGSNKSGSSGRSTPSLSGGSGSDPAPGKLFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSRGFGFITFQEPCTVEKVLKVPIHTLDGKKIDPKHATPKNRPRQANKTKKIFVGGVSQDTSAEEVKAYFSQFGPVEETVMLMDQQTKRHRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIMLGTLGVQLPTAPGQLIGARGAGVATMNPLAMLQNPTQLLQSPAAAAAAQQAALISQNPFQVQNAAAAASIANQAGFGKLLTTYPQTALHSVRYAPYSIPASAATANAALMQAHQAQSVAAAAHHHQQQQQQQHHHQQQTHNAHVAAAQQQQQSHHNAVSNPASQAHSAAAAAALAANAANGAGAAGAHSLAAAAQQAGLMAGNPLNAAAAAAAAAANPAAAYSNYALANVDMSSFQGVDWSTMYGMGMYV
Protein: Delta(14)-sterol reductase TM7SF2 (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (Another new gene 1 protein) (C-14 sterol reductase) (C14SR) (Putative sterol reductase SR-1) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2) (O76062)
Organism: Homo sapiens (Human)
Function: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Subcellular location: Microsome membrane {ECO:0000250|UniProtKB:Q71KT5}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:9878250}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Lanosterol 14-alpha demethylase
- 3-beta-hydroxysteroid-Delta
- Methylsterol monooxygenase 1
- Delta
- Lathosterol oxidase
- Squalene monooxygenase
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Ergosterol biosynthetic protein 28 homolog
- Delta
- Zinc finger HIT domain-containing protein 2
Sequence:
MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (Q6NPM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MATLPKLIQSMRNEVTKQPSLVLPSLRRAFSLYDQINLIDNVPEDQLRFQEFDETSFTVNGVKYEGSLLCVGNLLMSWSPRYFSDITTDSLSIFQTVRPIPELLIVGCGRYNHPLNPQVRQFVKSIGMKLETVDSRNAASTYNILNEEGRIVAAALLPYGVTS
Protein: Mediator of RNA polymerase II transcription subunit 25 (AtMED25) (Phytochrome and flowering time 1 protein) (Phytochrome and flowering time regulatory protein 1) (Q7XYY2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Positive regulator of shade avoidance and of jasmonate signaling. Acts in repression of PhyB-mediated light signaling and regulates the expression of FLOWERING LOCUS T (FT) and of CONSTANS (CO).
Subcellular location: Nucleus {ECO:0000269|PubMed:12815435}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 18
- Transcription factor MYC2
- Mediator of RNA polymerase II transcription subunit 19a
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 15a
- Transcription factor MYC3
Sequence:
MSSEVKQLIVVAEGTAALGPYWQTIVSDYLEKIIRSFCGSELNGERNPVSTVELSLVIFNSHGSYCACLVQRSGWTRDVDIFLHWLSSIQFGGGGFNEVATAEGLAEALMMFSPPSGQAQPSNDLKRHCILITASNPHILPTPVYRPRLQNVERNENGDAQAESRLSDAETVASYFAKCSVSLSVVCPKQLPTIRALYNAGKPNQQSADLSIDTAKNTFYLVLISENFVEACAALSHSATNLPQTQSPVKVDRATVAPSIPVTGQPPAPVSSANGPIQNRQPVSVGPVPTATVKVEPSTVTSMAPVPSFPHIPAVARPATQAIPSIQTSSASPVSQDMVSNAENAPDIKPVVVSGMTPPLRTGPPGGANVNLLNNLSQVRQVMSSAALAGAASSVGQSAVAMHMSNMISTGMATSLPPSQTVFSTGQQGITSMAGSGALMGSAQTGQSPGPNNAFSPQTTSNVASNLGVSQPMQGMNQGSHSGAMMQGGISMNQNMMSGLGQGNVSSGTGGMMPTPGVGQQAQSGIQQLGGSNSSAPNMQLSQPSSGAMQTSQSKYVKVWEGNLSGQRQGQPVLITRLEGYRSASASDSLAANWPPTMQIVRLISQDHMNNKQYVGKADFLVFRAMSQHGFLGQLQDKKLCAVIQLPSQTLLLSVSDKACRLIGMLFPGDMVVFKPQIPNQQQQQQQQLHQQQQQQQQIQQQQQQQQHLQQQQMPQLQQQQQQHQQQQQQQHQLSQLQHHQQQQQQQQQQQQQHQLTQLQHHHQQQQQASPLNQMQQQTSPLNQMQQQTSPLNQMQQQQQPQQMVMGGQAFAQAPGRSQQGGGGGQPNMPGAGFMG
Protein: CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Menage a trois) (RING finger protein MAT1) (p35) (p36) (P51949)
Organism: Mus musculus (Mouse)
Function: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- General transcription factor IIH subunit 4
- General transcription factor IIH subunit 1
- Cyclin-H
- General transcription factor IIH subunit 3
- General transcription factor IIH subunit 2
- Cyclin-dependent kinase 7
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIE subunit 2
- General transcription factor IIE subunit 1
Sequence:
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLENTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQEHEQRRLFIQKEEELQQALKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPRSMKPVTFSTGIKMGQQISLAPIQKLEEALYEYQPLQIETCGPQVPEQELLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPR
Protein: Cytochrome c oxidase subunit 8C, mitochondrial (Cytochrome c oxidase polypeptide 8 isoform 3) (Cytochrome c oxidase polypeptide VIII isoform 3) (COX VIII-3) (Cytochrome c oxidase subunit 8-3) (COX8-3) (Cytochrome c oxidase subunit VIIIC) (Q7Z4L0)
Organism: Homo sapiens (Human)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P10175}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10175}.
Interaction partners:
- Cytochrome c oxidase subunit 8A, mitochondrial
- Cytochrome c oxidase subunit 7A2, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
- Heme A synthase COX15
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 7B2, mitochondrial
- Cytochrome c oxidase subunit 6A2, mitochondrial
- Cytochrome c oxidase subunit 6A1, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 6B1
Sequence:
MPLLRGRCPARRHYRRLALLGLQPAPRFAHSGPPRQRPLSAAEMAVGLVVFFTTFLTPAAYVLGNLKQFRRN
Protein: GABA transporter 1 (AtGAT1) (Bidirectional amino acid transporter 1) (F4HW02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High affinity gamma-aminobutyric acid (GABA) transporter probably involved in GABA uptake into cells. When expressed in a heterologous system (Xenopus oocytes), imports GABA, butylamine, beta- and L-Alanine, 5-aminovaleric acid, 6-aminocaproic acid and 8-aminocaprylic acid, but does not mediate the transport of proline or glycine betaine.
Subcellular location: Cell membrane {ECO:0000305|PubMed:16407306}; Multi-pass membrane protein {ECO:0000305|PubMed:16407306}. Note=Plasma membrane.
Interaction partners:
- glutamate decarboxylase
- Amino-acid permease BAT1
- Glutamate decarboxylase 3
- Glutamate decarboxylase 2
- Protein SHOOT GRAVITROPISM 6
- Aluminum-activated malate transporter 8
Sequence:
MGGEERSGDGEKRGEEVVDAGSLFVLKSKGTWWHCGFHLTTSIVAPALLSLPYAFKFLGWAAGISCLVGGAAVTFYSYTLLSLTLEHHASLGNRYLRFRDMAHHILSPKWGRYYVGPIQMAVCYGVVIANALLGGQCLKAMYLVVQPNGEMKLFEFVIIFGCLLLVLAQFPSFHSLRYINSLSLLLCLLYSASAAAASIYIGKEPNAPEKDYTIVGDPETRVFGIFNAMAIIATTYGNGIIPEIQATISAPVKGKMMKGLCMCYLVVIMTFFTVAITGYWAFGKKANGLIFTNFLNAETNHYFVPTWFIFLVNLFTVLQLSAVAVVYLQPINDILESVISDPTKKEFSIRNVIPRLVVRSLFVVMATIVAAMLPFFGDVNSLLGAFGFIPLDFVLPVVFFNFTFKPSKKSFIFWINTVIAVVFSCLGVIAMVAAVRQIIIDANTYKLFADV
Protein: Adiponectin, C1Q and collagen domain containing (A0A0G2K845)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLLLQALLFLLILPSHEGITATEGPGALVPPPKETCAGWMAGIPGYPGHNGIPGRDGRDGTPGEKGEKGDAGVLGPKGDPGDAGMTGAEGPRGFPGTPGRKGEPGEAAYMYHSAFSVGLETRVTVPNVPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYFSYHITVYMKDVKVSLFKKDKAVLFTYDQYQEKNVDQASGSMLLHLEASFSTMIPTDCH
Protein: Protein MON2 homolog (Protein SF21) (Q7Z3U7)
Organism: Homo sapiens (Human)
Function: Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:30213940}.
Interaction partners:
- Protein DOP1A
- Protein DOP1B
- Transport and Golgi organization protein 1 homolog
- Vacuolar protein sorting-associated protein 26A
- F-box only protein 38
- Vacuolar protein sorting-associated protein 26B
- Autophagy-related protein 2 homolog B
- ADP-ribosylation factor-like protein 1
Sequence:
MSGTSSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDIIEQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRFCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPATSNQAGNNNLGGSVSAPANSGMVGIGGGVTLLPAFEYRGTWIPILTITVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITSMIEGELGELETECQTTTEEGSSPTQSTEQQDLQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSVQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPVVNVPVPVLIGPISGMSRPFVRTDSIGEKLGRYSSSEPPIVTDELEDLNLWWAAWNTWYRIGSESTKPPITFDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHSAISVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQIQLFAPAEWVALNYVPFAERSLEVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLRVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNENIDVEVVQLISNEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTQPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPASRVQNGES
Protein: Mitochondrial GTPase 1 (A8K900)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|PIRNR:PIRNR006230}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR006230}.
Interaction partners:
Sequence:
MAKGLKKMQSSLKLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEGEGLKNVIFTNCVKDENVKQIIPMVTELIGRSHRYHRKENLEYCIMVIGVPNVGKSSLINSLRRQHLRKGKATRVGGEPGITRAVMSKIQVSERPLMFLLDTPGVLAPRIESVETGLKLALCGTVLDHLVGEETMADYLLYTLNKHQRFGYVQHYGLGSACDNVERVLKSVAVKLGKTQKVKVLTGTGNVNVIQPNYPAAARDFLQTFRRGLLGSVMLDLDVLRGHPPAETLP
Protein: Profilin-1 (Profilin I) (P62963)
Organism: Rattus norvegicus (Rat)
Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity).
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Toll-like receptor 11
- Vasodilator-stimulated phosphoprotein
- Actin, cytoplasmic 1
- Protein diaphanous homolog 1
- Actin, cytoplasmic 2
- Actin nucleation-promoting factor WAS
- Diaphanous-related formin 2
- Cofilin 2
- Transforming protein RhoA
- Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Sequence:
MAGWNAYIDSLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVSITPAEVGVLVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNVTVTMTAKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
Protein: General negative regulator of transcription subunit 5 (Q12514)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus.
Interaction partners:
- General negative regulator of transcription subunit 2
- ATP-dependent RNA helicase DHH1
- General negative regulator of transcription subunit 4
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- General negative regulator of transcription subunit 1
- General negative regulator of transcription subunit 3
- Protein CAF40
- Poly
- Protein CAF130
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MSQRKLQQDIDKLLKKVKEGIEDFDDIYEKFQSTDPSNSSHREKLESDLKREIKKLQKHRDQIKTWLSKEDVKDKQSVLMTNRRLIENGMERFKSVEKLMKTKQFSKEALTNPDIIKDPKELKKRDQVLFIHDCLDELQKQLEQYEAQENEEQTERHEFHIANLENILKKLQNNEMDPEPVEEFQDDIKYYVENNDDPDFIEYDTIYEDMGCEIQPSSSNNEAPKEGNNQTSLSSIRSSKKQERSPKKKAPQRDVSISDRATTPIAPGVESASQSISSTPTPVSTDTPLHTVKDDSIKFDNSTLGTPTTHVSMKKKESENDSEQQLNFPPDRTDEIRKTIQHDVETNAAFQNPLFNDELKYWLDSKRYLMQPLQEMSPKMVSQLESSLLNCPDSLDADSPCLYTKPLSLPHPTSIFFPNEPIRFVYPYDVPLNLTNNENDTDNKFGKDSKAKSKKDDDIYSRTSLARIFMKFDLDTLFFIFYHYQGSYEQFLAARELFKNRNWLFNKVDRCWYYKEIEKLPPGMGKSEEESWRYFDYKKSWLARRCGNDFVYNEEDFEKL
Protein: Sll1390 protein (P74145)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Photosystem II CP47 reaction center protein
- Protein Thf1
- Photosystem II extrinsic protein O
- Photosystem II reaction center protein Z
- Photosystem II lipoprotein Psb27
- Photosystem II reaction center Psb28 protein
- Photosystem I reaction center subunit III
- CyanoQ
- Photosystem I reaction center subunit II
- Iron stress-induced chlorophyll-binding protein
Sequence:
MEFHRQLPMTVAPHHPFNLSIFCKRLLSFLFLTLVLLGLSPAPSLATGVYDLPILSPGSKTFLVDQAEAISLANENRLNSDLKKLAQSSGQEARFVVIRRLDFDATIDGFVNDLFERWYPDEASQSNQTLLVLDTLTNSTALRRGETAESLLTDEMVDSLLRETLAVPLKDGAKYNQALIEADKRLGAILAGQPDPGPPALEEISLEGTFTTAEETDDTSATVWVVVLLALATLIPMVTYFWYVGLPGR
Protein: Transmembrane protein (Q387C5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Letm1 RBD domain-containing protein
- ATP synthase delta chain
Sequence:
MTKYELKMQYFDEWMIRWRKFQTESDWEIEKGRQWWRRFNMAVSGALFCGLVLYTSGTATLKRQYGLPHFFDIGVDGQAKETMLKTLTSRWRYTPQGYGRVLITGVPTYILFVSLEHYRERRRMQQYLQQNTVFGEQMRRLLSTGKIEEYLPVNIKATLPASQQAIYNY
Protein: CCR4-NOT transcription complex subunit 11 (Q9W1C6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFLSIAPPLMDFEDELLWINQSNSDKVEIIYDKSNYITPNIKHLIEQAFLQPLSLQNQHILFDDLLKQNTDIARQYGLTPDKLPLLVESNPLISIEILLRLMTTSDITEYFNVLVNMDITLHSMEVVNRLTTSGPLPTEFIHLYISNCISTCETVKDKYMQSRLVRLVCVFLQSLIRNKIVNVRELFIEIEAFCVGFSKIKEAATLYRLIKHLETGESALSSNSLAK
Protein: Dehydration-responsive element-binding protein 1B (Protein DREB1B) (C-repeat/dehydration-responsive element-binding factor 1) (C-repeat-binding factor 1) (CRT/DRE-binding factor 1) (P93835)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates cold-inducible transcription. CBF/DREB1 factors play a key role in freezing tolerance and cold acclimation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366}.
Interaction partners:
- Transcription factor ICE1
- Protein COLD-REGULATED 15A, chloroplastic
- Low-temperature-induced 78 kDa protein
- Dehydrin COR47
- Zinc finger protein ZAT12
- Floral homeotic protein APETALA 2
- Zinc finger protein ZAT10
- Calmodulin-binding transcription activator 3
- Transcription factor MYB15
- E3 ubiquitin-protein ligase HOS1
Sequence:
MNSFSAFSEMFGSDYEPQGGDYCPTLATSCPKKPAGRKKFRETRHPIYRGVRQRNSGKWVSEVREPNKKTRIWLGTFQTAEMAARAHDVAALALRGRSACLNFADSAWRLRIPESTCAKDIQKAAAEAALAFQDETCDTTTTNHGLDMEETMVEAIYTPEQSEGAFYMDEETMFGMPTLLDNMAEGMLLPPPSVQWNHNYDGEGDGDVSLWSY
Protein: Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) (P62752)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62750}. Nucleus {ECO:0000250|UniProtKB:P62750}. Note=Although RPL23A is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL23A nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. {ECO:0000250|UniProtKB:P62750}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein eL34
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein eS1
Sequence:
MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII