wanglab/gogpt-training-data huggingface dataset:
Protein: GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) (Q06546)
Organism: Homo sapiens (Human)
Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.
Subcellular location: Nucleus.
Interaction partners:
- GA-binding protein subunit beta-1
- Transcription factor A, mitochondrial
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Nuclear respiratory factor 1
- GA-binding protein subunit beta-2
- Transcriptional repressor protein YY1
- DNA-directed RNA polymerase, mitochondrial
- Transcription termination factor 1, mitochondrial
- Histone-arginine methyltransferase METTL23
- Twinkle mtDNA helicase
Sequence:
MTKREAEELIEIEIDGTEKAECTEESIVEQTYAPAECVSQAIDINEPIGNLKKLLEPRLQCSLDAHEICLQDIQLDPERSLFDQGVKTDGTVQLSVQVISYQGIEPKLNILEIVKPADTVEVVIDPDAHHAESEAHLVEEAQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERLGIPYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPRGEILWSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVQSATPTTIKVINSSAKAAKVQRAPRISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVTECEQKKLAKMQLHGIAQPVTAVALATASLQTEKDN
Protein: Uncharacterized protein (Q54NT1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MPLPLSQRKSLRDNEEHLKNAHETIKSALGVDWTFEFDFDLITSKCKDTYVQESLGECFYKEVATSVAECIAEQTKDEMIKEALLEANTNQKIIVAPNEDKKFTQYWAYEFVNGDLRVHFRPSIANISDVKYFKLASVIPSPGVFSLPARINLKENAEKFTEALEKAKEVTKMDWSYDESSLETVYPNIEPTYQERIGDIFSEIVTNICYNLATRSADAMVLEALQEIAPNAKIVFKFDSKQSDYWVWKFVGGDLVVSFKSICNTGDNSYLDFEKLL
Protein: Uncharacterized protein C162.02c (O74419)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Putative acyl carrier protein, mitochondrial
- Membrane-bound O-acyltransferase gup1
- Tryptophan synthase
Sequence:
MLCDSSESVSFSSISKEEDTPIARLLKNAKETPDHRFISVYNERGIVAKYTYTELLRRVNTIAKFCDDLGLGKTVGIHMGHELDFLCSIFALWATGRTCVIFNQIWSQQVVRVLVKRLNISDLLYHEYKPKFEVDTLNATSLASLPLDIDAPCIRAGLEPEVALINHSSGSTGVPKSMPFLMKKYALGYDYGTPEFMNHLSTPMVMATSFALTTLSWINALYCNGNLLYPSSSISATCTSEAERLAWNVYYALRAGCERLIILPNLLVLTLQIMPDKEECFPACKLVAAGGEMVPANMYHTCKRVLPNATIYPQYGTTESGLVSFLAYNGKDTLHNKELVYFPGKTVKKLMLVTEDNEAVPEKIGCEGFVCVVTDVQSEPYVGDDAETIQSRNSTFINYDGQPAVRFADLAVWNSYKGKLGITIKGRLGRRVKRNGVFFDLKYFDQVVVGLKEVKDAFSFFIFNRFVLVYVPAYNGVDPVTLKQKLNKELRDHHLFSSCFPLADIPRNAAGKVDLKSIETYASKCLSVEDQRLPVLLNPVAIEISKIASKILQNPSLEGKDAPLYSCGLDSIHSVRFFHAIQSHFHLEGPIRYNMNSNCTPNSIASIIQKKSYNVSSITYELLNEDACALSRTIPKLSILPTNGQYFLLTGATGYFGRRFLEYLVKLNISVVCLVRESSDEAAKERLISLVPSLRISSENIIVWAAHVEEIRFGLDDAKWEFLVENVSRIYHMAAEVHWMKSYQELRPANVLGTKTVLELSVMGPKALYFISGGGQQEVELDDDTQSAKASGYALSKYVAELLCRKISDLGHPLIYVIRPGFIIANDGEILSRDFFWRFVATALRMGIWPQSDESQSLVFHISTTDALCMTLTQILEKEADAYAPLLAYDKFDGDEFACICESMKNVKLDFVTLEDWLKALEKDVDEKGEDHPLFALQHATKFALKSSMTPSNGLRNIYPLSETFLTKEAIANGLENLYIE
Protein: Antimicrobial peptide ISAMP (Q8MVA6)
Organism: Ixodes scapularis (Black-legged tick) (Deer tick)
Function: Has antimicrobial activity against B.cereus (MIC=5.8 ug/ml), B.subtilis (MIC=12.3 ug/ml), S.aureus (MIC=10.4 ug/ml), E.coli Edl 933 (MIC=3.2 ug/ml) and E.coli MG/655 (MIC=4.2 ug/ml). Non-hemolytic.
Subcellular location: Secreted {ECO:0000269|PubMed:12177149, ECO:0000269|PubMed:19852941}.
Interaction partners:
Sequence:
MRAVAIFIVTLLVLECVYFVMSEPDPGQPWQVKAGRPPCYSIPCRKHDECRVGSCSRCNNGLWGDRTCR
Protein: Urease accessory protein UreF (P18318)
Organism: Klebsiella aerogenes (Enterobacter aerogenes)
Function: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MSTAEQRLRLMQLASSNLPVGGYSWSQGLEWAVEAGWVLDVAAFERWQRRQMTEGFFTVDLPLFARLYRACEQGDIAAAQRWTAYLLACRETRELREEERNRGAAFARLLSDWQPDCPPPWRSLCQQSQLAGMAWLGVRWRIALPEMALSLGYSWIESAVMAGVKLVPFGQQAAQQLILRLCDHYAAEMPRALAAPDGDIGSATPLAAIASARHETQYSRLFRS
Protein: Uncharacterized vacuolar membrane protein YML018C (Q03730)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized trans-sulfuration enzyme YHR112C
- Altered inheritance of mitochondria protein 9, mitochondrial
- Vacuolar basic amino acid transporter 4
- Protein FMP42
Sequence:
MVSKDQTSFNKRWTLGLLMLGLVIILWVLSSFLINLIFEDDSYRKPFFITYTNTAAFIFYLFPTAKAVVVNYKDTGRANVHRELIMEEEGTGSDSNRSVDMTSPLLTNLEAGTHANQKKRLTLYETIKLSAEFCILWFTANLVTNASLAFTSVASQTILSTTSSFFTLFIGAICHVESLSKSKVLGSFISFVGIIMVTKSDSHQRYQRHIADVSGDDNDAVQVLIGNLLALAGAVLYGVYSTLLKREVGDETRVNMKIFFGFVGLFNLLFLWPSLIVLDFFGWEPFSLPKDPKVVVIIFVNCLITFVSDFCWAKAMLLTSPLTVTVGLSITIPLAMFGDVIFKHKTMSALYLFGATLILGSFFIINKSSEEEHFENSITASNYESVEVPAANN
Protein: H-2 class I histocompatibility antigen, K-W28 alpha chain (P03991)
Organism: Mus musculus (Mouse)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MAPCMLLLLLAAALAPTQTRAGPHSLRYFHTAVSRPGLGKPRFISVGYVDDTEFVRFDSDAENPRYEPRARWMEQVEPEYWERNTQIAKDNEQSSRVDLRTLLRYYNQSAGGSHTIQRMYGCDVGSDGRLLRGYEQVAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGAAERRRAYLEGACVEWLSRHLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPKPLTLRWEPPPSAVSNTVIIAVLVVLGAAIVTGAVVAFVMMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA
Protein: Chromatin-remodeling complexes subunit NGG1 (Transcriptional adapter 3) (P32494)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription regulator. Could inhibit GAL4 DNA-binding or its ability to activate transcription. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, SLIK and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SAGA complex subunit SPT8
- SAGA complex subunit SGF29
- SAGA complex subunit SUS1
- SAGA complex subunit HFI1
- SAGA complex/transcription factor TFIID complex subunit TAF6
- SAGA complex/transcription factor TFIID complex subunit TAF5
- SAGA complex subunit SPT7
- Histone acetyltransferase GCN5
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
- SAGA complex subunit ADA2
Sequence:
MPRHGRRGKLPKGEKLPKKEGGDNTPSKLLSSMLKTLDLTFERDIGMLNGKSVRSIPNKKTLLELQSQLDSLNEILGTIARGDQETIEALRKIRDSKNEKQANDEKQETSNADGQHESSTATEETNIIDKGVQSPPKPPPSNEISGTIENDVESIKQAADNMAKEEINEDKDLQVHRDQPREKRPFDSETENRATENENTQRPDNKKQKIDVDKMENDPTVKNPKSEFVVSQTLPRAAAALGLFNEEGLESTGEDFLKKKYNVASYPTNDLKDLLPGELPDMDFSHPKPTNQIQFNTFLAFVENFFKDLSDDNLKFLKMKYIIPDSLQFDKTYDPEVNPFIIPKLGPLYTDVWFKDENDKNSAYKKPSPYSNDASTILPKKSANELDDNALESGSISCGPLLSRLLSAVLKDDNDKSELQSSKIIRDGGLPRTGGEDDIQSFRNNNNDTVDMTLSQENGPSVQTPDNDIDEEASFQAKLAENKGSNGGTTSTLPQQIGWITNGINLDYPTFEERLKRELKYVGIYMNLPKDENNPNSDDPDWVTGREDDEISAELRELQGTLKQVTKKNQKRKAQLIPLVERQLAWQEYSSILEDLDKQIDQAYVKRIRVPKKRKKHHTAASNNVNTGTTSQIAQQKAANSSLKSLLDKRQRWINKIGPLFDKPEIMKRIPNESVFKDMDQEEDEDEADVFAQNTNKDVELN
Protein: Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8) (Q9DCJ1)
Organism: Mus musculus (Mouse)
Function: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q9BVC4}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z2K5}. Note=Targeting to lysosomal membrane depends on amino acid availability: mTORC1 is recruited to lysosome membranes via interaction with GTP-bound form of RagA/RRAGA (or RagB/RRAGB) in complex with the GDP-bound form of RagC/RRAGC (or RagD/RRAGD), promoting its mTORC1 recruitment to the lysosomes. {ECO:0000250|UniProtKB:Q9BVC4}.
Interaction partners:
- Rapamycin-insensitive companion of mTOR
- Serine/threonine-protein kinase mTOR
- DEP domain-containing mTOR-interacting protein
- Regulatory-associated protein of mTOR
- Target of rapamycin complex 2 subunit MAPKAP1
- Proline-rich protein 5
- Proline-rich AKT1 substrate 1
- TELO2-interacting protein 1 homolog
- Telomere length regulation protein TEL2 homolog
- GTP-binding protein Rheb
Sequence:
MNTTPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGIGDDVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSSNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG
Protein: Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase) (O81027)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the catabolism of branched amino acids such as leucine.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:14764908}.
Interaction partners:
- Probable enoyl-CoA hydratase 2, mitochondrial
- Hydroxymethylglutaryl-CoA synthase
- 3-ketoacyl-CoA thiolase 1, peroxisomal
- 3-ketoacyl-CoA thiolase 5, peroxisomal
- 3-ketoacyl-CoA thiolase 2, peroxisomal
- Acetyl-CoA acetyltransferase 1
- Acetyl-CoA acetyltransferase 2
- Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
- Dihydroxy-acid dehydratase, chloroplastic
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Sequence:
MQWNGVRRAHSIWCKRLTNNTHLHHPSIPVSHFFTMSSLEEPLSFDKLPSMSTMDRIQRFSSGACRPRDDVGMGHRWIEGRDCTTSNSCIDDDKSFAKESFPWRRHTRKLSEGEHMFRNISFAGRTSTVSGTLRESKSFKEQKYSTFSNENGTSHISNKISKGIPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFVSPKWVPQLADAKDVMDAVNTLDGARLPVLTPNLKGFQAAVSAGAKEVAIFASASESFSLSNINCTIEESLLRYRVVATAAKEHSVPVRGYVSCVVGCPVEGPVLPSKVAYVVKELYDMGCFEISLGDTIGIGTPGSVVPMLEAVMAVVPADKLAVHFHDTYGQALANILVSLQMGISIVDSSIAGLGGCPYAKGASGNVATEDVVYMLNGLGVHTNVDLGKLIAAGDFISKHLGRPNGSKAAVALNRRITADASKI
Protein: Secreted frizzled-related protein 1 (Secreted frizzled-related protein 5) (Sfrp5 protein) (Q6YNR8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAELKRQVSLTQAVTLALVLLTSASSAEEYDYYSWQSDNFHSGRFYAKQPQCVDIPADLRLCYNVGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFLCSLFAPVCLDRPIYPCRSLCEAVRDSCAPVMETYGFPWPEMLQCEKFPIDNDLCIPMQFSAGHATQTPVSKVCPPCDNELKADTIMEHYCASDFALKMKIKEAKKEKGDRKLIAAQKKKKVLKMGILRKKDLKKLTLYIKNGANCPCSQLDNLGSNFLIMGRKVDQQLLLMSIHKWDKKSKELKFAIKYIKSQQCPTYHSVFQ
Protein: Uncharacterized protein, isoform A (A1Z8M8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MESSSDSCSLSSSTTPDVGLADQQRNMAGSAQDQSEDQSQTFLGATELDDELIKQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLFDFQRDIEGPVIENISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKKITDISTQSISRYCSKLTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVEALARGCVKLRKFSSKGCKQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTLEVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIRHLTTGSCAAEILSVLELDNCPLITDRTLEHLVSCHNLQRIELFDCQLITRTAIRKLKNHLPNIKVHAYFAPGTPPAVTSGHRPRYCRCCEIL
Protein: Transcription factor bHLH61 (Basic helix-loop-helix protein 61) (AtbHLH61) (bHLH 61) (Transcription factor EN 46) (bHLH transcription factor bHLH061) (Q9LXA9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Wall-associated receptor kinase-like 2
Sequence:
METELTQLRKQESNNLNGVNGGFMAIDQFVPNDWNFDYLCFNNLLQEDDNIDHPSSSSLMNLISQPPPLLHQPPQPSSPLYDSPPLSSAFDYPFLEDIIHSSYSPPPLILPASQENTNNYSPLMEESKSFISIGETNKKRSNKKLEGQPSKNLMAERRRRKRLNDRLSLLRSIVPKITKMDRTSILGDAIDYMKELLDKINKLQEDEQELGSNSHLSTLITNESMVRNSLKFEVDQREVNTHIDICCPTKPGLVVSTVSTLETLGLEIEQCVISCFSDFSLQASCFEVGEQRYMVTSEATKQALIRNAGYGGRCL
Protein: Coatomer subunit beta (Beta-coat protein) (Beta-COP) (Q66HV4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P23514}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P23514}; Peripheral membrane protein {ECO:0000250|UniProtKB:P23514}; Cytoplasmic side {ECO:0000250|UniProtKB:P23514}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250|UniProtKB:P23514}; Peripheral membrane protein {ECO:0000250|UniProtKB:P23514}; Cytoplasmic side {ECO:0000250|UniProtKB:P23514}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250|UniProtKB:P23514}.
Interaction partners:
- Coatomer subunit beta
- Coatomer subunit gamma-2
- Coatomer subunit delta
- Coatomer subunit alpha
- Coatomer subunit delta
- Coatomer subunit zeta
- Coatomer subunit epsilon
- ADP-ribosylation factor GTPase-activating protein 3.
- ADP-ribosylation factor GTPase-activating protein 2.
- Coatomer subunit zeta
Sequence:
MTAAENVCYTLINVTNDSEPPSEVSLKTDLEKGEIKAKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGKLLQEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKESELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVHTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIELKEHPTHERVLQDLVMDILRVLTTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVTEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDTNEAAAADVLEFVREAIQRFDNLRPLIIEKMLEVFHAIKTVKIYRGALWILGEYCSTKEDIQSVMTEVRRSLGEIPIVENELKKEAGEVKPEEEVTAAPAPKLVTEMGTYVTQSALSTSRPSKKEEDRPPLRGFLMDGDFYVAASLATTLTKVALRYVALAEDKRRQNSFVAEAMLIMATVLHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRRSLSHMLAVRLEEEKLSQKKESEKRNVTVQADDPISFMQLTAKNEMASKEDQFQLSLLAAMGNTQRKEATDPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPASCTDAEFRQMWAEFEWENKVTVNTNITDLNDYLLHILKSTNMKCLTPEKALSGICGFMAANLYARSIFGEDALANVSIEKPIHLGVDAPVNGHIRIRAKSQGMALSLGDKINLSQKRTAS
Protein: Bcl-2-like protein 12 (Bcl2-L-12) (Bcl-2-related proline-rich protein) (Q9HB09)
Organism: Homo sapiens (Human)
Interaction partners:
- Apoptosis regulator Bcl-2
- Caspase-7
- Ras-related protein R-Ras
Sequence:
MAGSEELGLREDTLRVLAAFLRRGEAAGSPVPTPPRSPAQEEPTDFLSRLRRCLPCSLGRGAAPSESPRPCSLPIRPCYGLEPGPATPDFYALVAQRLEQLVQEQLKSPPSPELQGPPSTEKEAILRRLVALLEEEAEVINQKLASDPALRSKLVRLSSDSFARLVELFCSRDDSSRPSRACPGPPPPSPEPLARLALAMELSRRVAGLGGTLAGLSVEHVHSFTPWIQAHGGWEGILAVSPVDLNLPLD
Protein: WUSCHEL-related homeobox 2 (Q6X7K1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in embryonic patterning. Required for apical embryo development after fertilization. Its specific localization to the apical daughter cell of the zygote, while WOX8 is confined to the basal cell, suggests that the asymmetric division of the plant zygote separates determinants of apical and basal cell fates.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Mitogen-activated protein kinase kinase kinase YODA
- Probable WRKY transcription factor 2
- Nuclear transcription factor Y subunit B-9
- B3 domain-containing transcription factor LEC2
- Auxin efflux carrier component 7
- B3 domain-containing transcription factor FUS3
- Glycine-rich protein
- Somatic embryogenesis receptor kinase 1
- Protein RKD4
- Homeobox-leucine zipper protein MERISTEM L1
Sequence:
MENEVNAGTASSSRWNPTKDQITLLENLYKEGIRTPSADQIQQITGRLRAYGHIEGKNVFYWFQNHKARQRQKQKQERMAYFNRLLHKTSRFFYPPPCSNVGCVSPYYLQQASDHHMNQHGSVYTNDLLHRNNVMIPSGGYEKRTVTQHQKQLSDIRTTAATRMPISPSSLRFDRFALRDNCYAGEDINVNSSGRKTLPLFPLQPLNASNADGMGSSSFALGSDSPVDCSSDGAGREQPFIDFFSGGSTSTRFDSNGNGL
Protein: Mitochondrial magnesium exporter 1 (Q9VM51)
Organism: Drosophila melanogaster (Fruit fly)
Function: Mediates efflux of magnesium ions from mitochondria, suggesting a role in magnesium homeostasis.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:26462626}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Large ribosomal subunit protein bL19m
- Gamma-secretase subunit Aph-1
Sequence:
MEEVEISTEKKSNPVKSFIAGGVGGMCNVLVGHPLDTIKVRLQTMPTPPPGQPPRYKGVIDCAARTFRYEGFRGFYRGISAPLVGVTPIYAVDFAVYAAGKRLFQTDDHIRLTYPQIFAAGALAGVCSALVTVPTDRIKVLLQTQTVSNGPLLYNGTIDTAAKLYRQGGIRSLFKGTCACILRDSPTGFYFVTYEFLQELARKKSANGKISTTSTILSGGTAGIVFWTLAVPFDVLKSRLQSAPEGTYKHGIRSVFRNLMATEGPKALFRGILPILLRAFPSTAAVFFGVELTNDLLKA
Protein: Mediator of RNA polymerase II transcription subunit 28 (Q9LFA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 10a
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 25
- Mediator of RNA polymerase II transcription subunit 22a
- ATP-dependent DNA helicase Q-like 2
- Mediator of RNA polymerase II transcription subunit 22b
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 32
- Mediator of RNA polymerase II transcription subunit 8
Sequence:
MDYQQKPPQSSDPSPSPPDRPPGIRSPETPSNNQNNDIEDIMACVTALEAALLPCLPARELQAIDRSPHPSHQIDVERHARDFMEAAKKLQLYFMGLKREDRAPSRAESLKKDIAVMEEELKTKDELIKKHMRLFQESQKLVKEQIEKHRDELEKV
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q0ZA03)
Organism: Triticum aestivum (Wheat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MDSLRLAIAAALLFLAALAAAAAAADDAQLLDDFRAALPTGNALDGWAARDGACRFPGAVCRGGRLTSLSLAAVALNADFRAVAATLLQLSAVERLSLRGANVSGALAAAAGARCGSKLQELDLSGNAALRGSVTDVAALAGSCAGLKTLNLSGDAVGTAKTAGAGGGGQGFAALDALDLSSNKIAGDADLRWMVGAGLGSVRWLDLAWNKISGGLSDFTNCSGLQYLDLSGNLIAGDVAAGALSGCRSLRALNLSSNHLAGAFPPNIAGLTSLTALNLSNNNFSGEVPADAFTGLQQLQSLSLSFNHFSGSIPDSVAALPDLEVLDLSSNNFSGTIPSTLCQDPNSRLRVLYLQNNYLSGSIPEAVSNCTDLVSLDLSLNYINGSIPESLGELGRLQDLIMWQNLLEGEIPASLSSIPGLEHLILDYNGLTGSIPPELAKCKQLNWISLASNRLSGPIPPWLGKLSNLAILELSNNSFTGQIPAELGDCKSLVWLDLNSNQLNGSIPPQLAEQSGKMTVGLIIGRPYVYLRNDELSSQCRGKGGLLEFSSIRSEDLGRMPSKKLCNFTRMYMGSTEYTFNKNGSMIFLDLSVNQLDSEIPKELGNMYYLMIMNLGHNLLSGAIPTELAGAKKLAVLDLSYNRLEGPIPSSFSSLSLSEINLSSNQLNGTIPELGSLATFPKSQYENNSGLCGFPLPACEPHTGQGSSNGGQSNRRKASLAGSVAMGLLFSLFCIFGLVIIAIESKKRRQKNDEASTSRDIYIDSRSHSGTMNSNWRPSGTNALSINLAAFEKPLQKLTLGDLVEATNGFHNESLIGSGGFGDVYKATLKDGRVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKIGEERLLMYDFMKFGSLEDGLHDRKKIGIKLNWAARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLVDENLEARVSDFGMARMMSVVDTHLSVSTLAGTPGYVPPEYYQSFRCTTKGDVYSYGVVLLEPLTGKPPTDSTDFGEDHNLVGWVKMHTKLKITDVFDPELLKDDPTLELELLEHLKIACACLDDRPSRRPTMLKVMTMFKEIQAGSTVDSKTSSVATGLSDDPGFAVMDMTLKEAKEEKD
Protein: INO80 complex subunit B (High mobility group AT-hook 1-like 4) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) (Q99PT3)
Organism: Mus musculus (Mouse)
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9C086}. Nucleus, nucleolus {ECO:0000269|PubMed:15556297}.
Interaction partners:
- RuvB-like 1
- RuvB-like 2
- Actin-related protein 5
- Chromatin-remodeling ATPase INO80
- INO80 complex subunit E
- INO80 complex subunit C
- INO80 complex subunit D
- TCF3 fusion partner homolog
- Actin-related protein 8
- Nuclear factor related to kappa-B-binding protein
Sequence:
MSACVPTVSSPLPLQDPMSKLWRRGSTSGAMEAPEPGETLELSLAGAHGHGVHKKKHKKHKKKHKKKHHQEEEAGPTLQTPAKPQLKLKIKLGGQVLGTKSVPTFTVIPEGPRSPSPLMVVDNEEEPMEGVPLEQYRAWLDEDSNLSPSPLRDLPGDLEGQEEEEEQRWLDALEKGELDDNGDLKKEINERLLTARQRALLQKARSQPSPTLPLPVGGGCPAPALTEEMLLKREERARKRRLQAARRAEEHKNQTIERLTKTAAPSGRGGRGAARGERRGGRAAAPAPAPMVRYCSGAQGSTLSFPPGVPTPTAVAQRPAPSGPAPRCSVPGCPHPRRYACSRTGQALCSLQCYRINLQLRLGGPEGPGSPLLAT
Protein: aromatase (EC 1.14.14.14) (Cytochrome P-450AROM) (Estrogen synthase) (Q8JH69)
Organism: Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MIPETLNPLNYYTSLVPDLIPAATVPIIILICVLFLIWNHEGTSSIPGPGYCMGIGPLISHGRFLWMGVGNACNYYNKTYGEFVRVWFSGEETFIISKSSSVFHVMKHWNYVSRFGSKLGLQCIGMYENGIIFNNNPAHWKEIRPFFTKALSGPGLVRMIAICVESTIVHLDKLEEVTTEVGNVNVLNLMRRIMLDTSNKLFLGVPLDENAIVLKIQSYFDAWQALLLKPDIFFKISWLCKKYEEAAKDLKGAMEILIEQKRQKLSTVEKLDEHMDFASQLIFAQNRGDLTAENVNQCVLEMMIAAPDTLSVTLFIMLILIAEHPTVEEKMMREIETVMGDRDVQSDDMPNLKIVENFIYESMRYQPVVDLIMRKALQDDVIDGYPVKKGTNIILNIGRMHKLEFFPKPNEFSLENFEKNVPSRYFQPFGFGPRGCVGKFIAMVMMKARRCRVQTMKGRALINIQKMNDLSMHPIERQPLLVMVFTPRRA