Protein: Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) [Cleaved into: Aggrecan core protein 2] (Q29011)
Organism: Sus scrofa (Pig)
Function: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Hyaluronan and proteoglycan link protein 1
- Collagen type II alpha 1 chain
- Transcription factor SOX-9
- Cartilage oligomeric matrix protein
- Decorin
- Collagenase 3
- Fibromodulin
- A disintegrin and metalloproteinase with thrombospondin motifs 4
- Tenascin-R
- Biglycan
Sequence:
MTTLLLVFVTLRVIAAAISVEVSEPDNSLSVSIPQPSPLRVLLGGSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGQVRVNSAYQDRVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGTVILTVKPVFEFSPTAPEPEEPFTFAPGTGATAFPEAENRTGEATRPWAFPEESTPGLGAPTAFTSEDLVVQVTMAPGATEFPGQPRLPGGVVFHYRPGSSRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSTPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLASTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSAVAPSPGEEEGGTPTSLPDLEERIATQVGPGVAAVPVGEETTEVAAFTTEPENRTEWEFVYTPVGTSPLPGIPPTWPPTSAATEEGTEGPSATEAPSTSEEPFPSEKPFPSEEPFPSEEPFPSEKPSASEEPFPSEQPSTLSAPVPSRTELPGSGEVSGAPEVSGDFTGSGEVSGHLDYSGQPSGEIASGLPSEDLDSSGLTSAVGSGLPVESGLASGDEDKITWSSTSKVDRLPSGGEGPEGSVSGVEDLSGLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDLSRLPSGEGPEISASGIEDISQLPSGEGPEISASGIEDLSRLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISVSGVEDLSRLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDLSRLPSGEGPDISASGVEDLSRLPSGEGPEISASGIEDLSRLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGGEGHLETSASGVEDLSGIPSGGEDHLESSASGVGDLSGLPSGREGLEIYASGAEDLSGLTSGKEDLAGSASGDLDVGRMPSGTLESGQAPEVSGLPSGFSGEYSGVDLGSGPSSGLPDFSELPSGFPTVSLVDTTLVEMVTATTASELEGRGTIGVSGAGETFGLPFSELDISGGASGHPSGAELSGQASGSPDISGETSGLFDVSGQPSGFPDISGGTSGLFEVSGQPSGFSGATSGVTELSGLSSGQPDISGDASGVLSGVGQPFGLTDVSGETSGVPDLSGQPSGWPGFSGMPSGTPDLVSSATSGSGESSGITFVDTSLVEVTPTTRKEEEGLGSVELSGLPSGEADLSGASGVVDVSGLASGATDSSGFTSQPPEFSGLPSGVTEVSGESSGVEIGSSLPSGAYDGSGLPLSAPTVYLVDRTLVESVTQAPTAQEAGEGPPGTLELSGAHSGVPDMSGDHSGSVDLSGLQSGLAEPSGEPASTPYFSGDFSVTTDISGDSSAATSTSGEASGLPEVTLIASEFVEGVTEPTVSQELGQRPPVTHTPQLFESSGEASASGDVPRFPGSGVEAPPIPESSRESSAYPEAETGASAAPEASGGASGSPDLTEATSAFHEADLEGTSGLGVSVSTSAFQEGTREVSAAPEVSRESTTTYDVGPEASGLPLATPVSSGDRTEVSGDLSGHTSGLEVAISTAIPEYAWTQQTQRPAEAPLEIESSSPVHSGEEMPTAKPATSQTEASIPTPPGQTDESEATTADQKLCENGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINSLVRYQCTEGFVQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRSLRRSRPSTGP