wanglab/gogpt-training-data huggingface dataset:
Protein: Protein I'm not dead yet (INDY transporter protein) (drIndy) (Q9VVT2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:12391301}; Multi-pass membrane protein {ECO:0000269|PubMed:12391301}. Note=Basolateral membrane of cells in the midgut.
Interaction partners:
- G-protein coupled receptor Mth
Sequence:
MATETTKMIYTPPPLDIKMEIEIGEQPQPPVKCSNFFANHWKGLVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGVCKINHEPQYQIVGGNKKNNEDEPPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGWADLLNSKDIRNSMPTIFVVVMCFMLPANYAFLRYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQIYAAAALGNKTH
Protein: Protein jim lovell (Protein TKR) (Tyrosine kinase-related) (dTKR) (P14083)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has a regulatory role during midline cell development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320}.
Interaction partners:
Sequence:
MLKDAHQKLIKHRQSTKLSMTDFACQAAPVKQPLPLELPLPLSVQLQLLAKTPTSDHAPMHSTPPTTPPTPPPLPLNMSQSASAVTEAATPENSLPATPPSEGALAVPSAPQDHYSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESSVPEHTPTPAASPDDFGMLDTSMLSSTFEDECPTMVRPSKGGKLLMPSARLFGNASSAIAALGLRRKREQESDRDLESDQELGGSSPMPRRKQARPRRRSGDVPHDFTLNKTDAESLQTVIKHELLERAERDQEEAPDQDNSQGEAEKISSSPAKTLVERAKEQKSMKEEGSDQPRSLNENHHQLELDDEDDDDQDHEEEEEQDIEELIHTTNELRRQAAAAAANAAAMSPNPSPCLSDGPEDLCTTKKGKELISGPSSSADCESNNNNSSKLQDNNQRIMLSLKDIRQLNANPNPTAIHTPTSCSGGNNGLLTFPPPGLRPPGLPDSPPCHMEALEAQMHAAAAAAVAAAGSGEHPFHHMEHQMEMSLAAAAAAAAMHQREPRDPRDGRDHNAFASNLLGPMGMPPFGGHNGGHPGNSGPGNGCPGQAAHERLEESMNRLSKELGKEFGKEFGKEFGKEFGPASPMSLQGPFNAPDGPPHPPSPLPFPGMSSAMTLTPPHMFGLDSPLGLFPPGIDPGKLYNPLMEMSDPRDMPGGPPPFLKKKMPRPKGQHSAPRGGPPRSWTNTELTEALQHVWNKKMTTSQASRIFGIPYNSLLMYVRGKYGKSLKLEQLRKDCISGPPIEMLQMGIGGGSGGSTKNEKSKERKEKEKDKNSMSSNGSGGSANSQGGAPTSGSGPMQHSGELGPMGQLDLDLGLPLGPPGGPRSNSSEPDLLSAPNALFNPFNPQGFYPDFSGGFPGLPLSMLNLLPPAERHHAAAAMHHLGVSMDEDCKSVGSKQSSSVDEDYSGPGIPLSLEHRREISATGPPLTPSNGGTGHD
Protein: Guanylyl cyclase-activating protein 1 (Q90WX4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGNSTGSTVDDLQAVEMHLWYKKFMTECPSGQLTLHEFKQFFGLRGLDPKANAYIEQMFRTFDMNKDGYIDFMEYVAALSLVMRGKMEHKLRWYFKLYDVDGNGCIDRYELLNIIKAIRAINGSETQESSAEEFTNRVFERIDINGDGELSLDEFVAGARSDEEFMEVMMKSLDLTHIVAMIHNRRHSV
Protein: Cytochrome P450 78A9 (EC 1.14.-.-) (Q9SLP1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays role in seed and fruit development. Functions probably in association with CYP78A6 in the regulation of seed growth.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Auxin response factor 18
Sequence:
MATKLDTSSLLLALLSKCSLLTQTNLALSLLVASLASLALSLFFWSHPGGPAWGKYFLHRRRQTTVIPGPRGLPFVGSMSLMSNTLAHRCIAATAEKFRAERLMAFSLGETRVIVTCNPDVAKEILNSPVFADRPVKESAYSLMFNRAIGFAPYGVYWRTLRKIASNHLFSPKQIKRSETQRSVIANQIVKCLTKQSNTKGLCFARDLIKTASLNNMMCSVFGKEYELEEEHEEVSELRELVEEGYDLLGTLNWTDHLPWLSEFDPQRIRSRCSNLVPKVNRFVNRIISDHREQTRDSPSDFVDVLLSLDGPDKLSDPDIIAVLWEMIFRGTDTVAVLIEWILARMVLHPDIQSTVHNELDQIVGRSRAVEESDVVSLVYLTAVVKEVLRLHPPGPLLSWARLAITDTIIDGRRVPAGTTAMVNMWAIAHDPHVWENPLEFKPERFVAKEGEVEFSVLGSDLRLAPFGSGRRVCPGKNLGLTTVTFWTATLLHEFEWLTPSDEKTVDLSEKLRLSCEMANPLAAKLRPRRSFSV
Protein: FAD-linked oxidoreductase ZEB1 (EC 1.-.-.-) (Zearalenone biosynthesis protein 1) (A0A0E0RTV6)
Organism: Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)
Function: FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of zearalenone (ZEA), a nonsteroid estrogen that is a contaminant of cereal grains and causes estrogenic disorders in humans and animals. The ZEA backbone is synthesized from a single acetyl-CoA molecule and eight malonyl-CoA molecules. The reducing polyketide synthase ZEA2 is proposed to synthesize a reduced hexaketide intermediate by using different combinations of its reductive domains during each round of condensation. The hexaketide thioester is then transacylated to the non-reducing polyketide synthase ZEA1 and is further condensed with three malonyl-CoAs without reductive tailoring to yield a mixed reduced/unreduced nonaketide. ZEA1 must be able to interact with ZEA2 to facilitate starter-unit acyltransfer and initiate polyketide biosynthesis. ZEA1 also mediates the required C2-C7 cyclization to form the resorcylate core and catalyzes the formation of the macrolactone. ZEB1 is then responsible for the chemical conversion of beta-zearalenonol (beta-ZOL) to ZEA in the biosynthetic pathway.
Interaction partners:
Sequence:
MKLSPSKYLPVLLGTLSLTIANPSADCKCFPGDDCWPSAAEWKALNTSVSGNLIKTVPLGAPCHDPMFKGDVCQSLRQQWQNATIHFASSSSVMAPFFANQSCDPFQPRIRPCELGNYVSYAIAAETTSDVQNAIAFARANHIRLVIRNTGHDYLGRSTGAGALGVWTHHLKNIEFVDWDDDTYTGNAVKLGAGVQGFEVLEAARSRGLVVVGGECPTVGIAGGYSQGGGHSALSTSFGLSVDNVLSWEVITAKGELLTVNKDENPDLFWALRGGGGGTFGVVISMTVKAHPGTITSGASLSFSTDTNSEEAFWAGIQVFQDTLEDMVDAGTMVIHIITNTSFLIAPLTAYNKTEAQVKVIMKPFISSLTSKHVDFDVTYKESKTYYDHYNEFLGPLPYGKIRVGFEQYGGRLIPRSVVPNFTETLRQVTNMGVTWVGVATDVGPFGTRATTSVHPAWRSTLVHALLSTPWDFTKPWHDMIKLQDLMTNVIMPKVEAVTPGSGAYVNEADFRQPNYQDVFWGDNYKDLLEVKEKWDPEHFFFVPKGVGSEIWSIAEDGRMCKSAL
Protein: SSD domain-containing protein (H1UBK6)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MTDFEHEIVKLVYDSGKYPLIYGQVASDNLVAEEVRRLGTTTAPWLSVALAILGVFLMVCSLRYRRAESKPLEACLGALIPVLSGITTIGMVSATGLAFQSIIVSTLFLVIAIGIDDIFIILAAWHRTDKHLEIPERMALTVQEAGCSMTVTTVTNLVSFGNGVLSTTPVLQTFAIYSSVASVVCYIYQLVIFPAIIAITAPNEYQKLGDSKEEKTWDIIKTMGQWSDRQWHKLAGAISTSWVRLLTISILLGYWYLSVYGIATMETDLTIQKMADQNARIVKFKRDADIILKEMQSVAILVKSPKDLRKMENLKKLQKMIKDFESAKNSFGNESTVCWLQSYIDFLTFYQENDEEFDNDDVITENSAKKSNFSEEKPAKSRFQFTYSDLPAFLNSEPQYKPMIRYSESECVKNSEKCIESFIFTTGFTDVVKYNEMYPVVSEWRKIAANYSEFEVYPYTERSNFVDQTVDMVDNIWNTVISEVICMGLTFILFIPDLISIFSAVFALFSVNFGVFGFLSIWGVGMDPVSTASLLMSIGFSVDISAHISYHYYQVDKPTARQKLEHVYSHIGWPTLQGGLSTMLAMMPIVLAPSYLGMVFLKTVILVCTFGLIHGLIVLPVFLSFFTEISGFCRRKSVKIADSPSSSIDNLPKTISIRDIGSQKKYQKDHENNNNNIEKF
Protein: AO66 ankyrin (Ankyrin-2) (G5ECZ1)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MSNEGDPPQPQQQQPESQEVQAPAAPEPGRAEGSASFLRAARAGDLEKVLELLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVRLLLERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGYVSVVETLRTVTETTVITETTTVDERYKPQNPEAMNETMFSESEDEGQAAEHEAVAAHEKDFSDNLTQGLQDSTGVHMIHTGEQLLQRSQELENGGAIPKINSGGMSPEKEFAKIAPVATSSPIATSNSQSFGIAPRAGSISGQFQQQPLHGAGPEDNLEELVRRAQNHPINAGNYDNGGVAMLENGHADNVPIGHHVTQPSFLISFLVDARGGAMRGCRHSGVRIIVPPRKASQPIRVTCRYLRKDKLAHPPPLSEGEELASRILEMAPAGAKFLGPVILEVPHFASLRDREREIVILRSDDGQHWKEHQLEATEDAVQEVLNESFDAEDLAQLDDLQTPRITRILTSDFPMYFAVVTRVRQEVHCVGPEGGVIISSVVPRVQAIFPDGSLTKTIKVSVQAQPVPQEMVTRLHGNRVAVSPIVTVEPRRRKFHKPITLCIPLPQSNNRGMLTQYSGQQGQEPPTLRLLCSITGGSAPAQWEDITGTTQLTFTGDEVSFTTTVSARFWLMDCQTPRDAARMAQEVYNEAISIPYMAKFAVFARRTFPVEGQLRVFCMTDDKEDKTLEKQEHFKLIAKSRDVEVLKGKHQFLEFSGNLVPITKSGDQLSLFFLPFQENRLAFMVKTRSNDDNEAATEGRIGFMAEPKIRSDALPPQQPICTLAISLPEYTGEIKTAPPPKKDLTPFEQRYGSALEKDLPEFVHQNVLKGIGADWPRLGRALEVPHRDIQHIRQNYPGQECKNTLKIWIHLKKEDANQDNLDQALRQIGRDDIVRSIAYGEPDALINYSQADSPSQKREPIRHFEEVPAATLVKREVRTEDLVTREPVQPTHHVEQATTVVQEPSYSAPVHHSPVPEEPEMEEEAPVAEMRTVVRTERHVHDSEDGPVVEERTITTTYEDDVAVNENIVDRTVPLNEDEQQKWEELNRLADESSPSPAQRSTIVAESTSEQVPEDVEQSVESESHREDDGTIVTTTVTTSHISESPSGSPTRRSVEPEEHRHSQHEDHEASGAEQHSGQDSGTTQKKETAEEGFTNEDGSVVVSKKMTRVVTTTRTTLPGEGEEPSAPGE
Protein: Magnetite biomineralization protein Mms6 (Magnetosome protein Mms6) (Q6NE76)
Organism: Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)
Function: Promotes the formation of magnetite in Fe(2+)-rich conditions, when magnetite is not readily formed. Binds both Fe(2+) and Fe(3+). May help control the production of crystals with a specific morphology (By similarity). May function with MamX, MamY amd MamZ in biomineralization (Probable). The 4 genes of this operon collectively influence magnetosome size and number.
Subcellular location: Magnetosome membrane {ECO:0000269|PubMed:14766587}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Magnetosome protein MmsF
- Magnetosome protein MamB
- Probable magnetosome protein Mms36
- Magnetosome protein MamF
- Magnetosome protein MamT
- Magnetosome protein MamI
- Magnetosome protein MamM
- Magnetosome-associated protein MamJ
- Liposome tubulation protein MamY
- Magnetosome protein MamH
Sequence:
MGEMEREGATAKVGAGKVGAGKVGAAKAGAAPAAAQGAGTKVVAAQGAGTKVVAAQGAGAKAAAVGVGKVGAGAKAVGGTIWSGKGLALGLGMGLGAWGPLILGVVGAGAVYAYMKSRDIEAAQSDEEVELRDALS
Protein: ShKT domain-containing protein (Q22613)
Organism: Caenorhabditis elegans
Interaction partners:
- C-type lectin domain-containing protein
- Lysozyme-like protein 1
- Pathogenesis-related protein 5-like
Sequence:
MFSLKTVALYFLVIMSVFVVYTSAACADAEDGHCAVFAELCDNADFAAYTSKCPKTCGKC
Protein: Subtilisin-like protease SBT1.2 (EC 3.4.21.-) (Cucumisin-like serine protease SDD1) (Protein STOMATAL DENSITY AND DISTRIBUTION 1) (Subtilase subfamily 1 member 2) (AtSBT1.2) (Subtilisin-like protease SDD1) (O64495)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine protease involved in the negative regulation of stomatal density and distribution. Not active on EPFL6 (AC Q1PEY6). Positive regulator of water use efficiency (WUE).
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Protein EPIDERMAL PATTERNING FACTOR 1
- Trihelix transcription factor GTL1
- Protein EPIDERMAL PATTERNING FACTOR 2
- Transcription factor SPEECHLESS
- EPIDERMAL PATTERNING FACTOR-like protein 9
- LRR receptor-like serine/threonine-protein kinase ERL1
- LRR receptor-like serine/threonine-protein kinase ERL2
- Transcription factor MUTE
- Protein TOO MANY MOUTHS
- Transcription factor FAMA
Sequence:
MEPKPFFLCIIFLLFCSSSSEILQKQTYIVQLHPNSETAKTFASKFDWHLSFLQEAVLGVEEEEEEPSSRLLYSYGSAIEGFAAQLTESEAEILRYSPEVVAVRPDHVLQVQTTYSYKFLGLDGFGNSGVWSKSRFGQGTIIGVLDTGVWPESPSFDDTGMPSIPRKWKGICQEGESFSSSSCNRKLIGARFFIRGHRVANSPEESPNMPREYISARDSTGHGTHTASTVGGSSVSMANVLGNGAGVARGMAPGAHIAVYKVCWFNGCYSSDILAAIDVAIQDKVDVLSLSLGGFPIPLYDDTIAIGTFRAMERGISVICAAGNNGPIESSVANTAPWVSTIGAGTLDRRFPAVVRLANGKLLYGESLYPGKGIKNAGREVEVIYVTGGDKGSEFCLRGSLPREEIRGKMVICDRGVNGRSEKGEAVKEAGGVAMILANTEINQEEDSIDVHLLPATLIGYTESVLLKAYVNATVKPKARIIFGGTVIGRSRAPEVAQFSARGPSLANPSILKPDMIAPGVNIIAAWPQNLGPTGLPYDSRRVNFTVMSGTSMSCPHVSGITALIRSAYPNWSPAAIKSALMTTADLYDRQGKAIKDGNKPAGVFAIGAGHVNPQKAINPGLVYNIQPVDYITYLCTLGFTRSDILAITHKNVSCNGILRKNPGFSLNYPSIAVIFKRGKTTEMITRRVTNVGSPNSIYSVNVKAPEGIKVIVNPKRLVFKHVDQTLSYRVWFVLKKKNRGGKVASFAQGQLTWVNSHNLMQRVRSPISVTLKTN
Protein: Slow troponin T (Troponin T1, skeletal, slow) (Troponin T2c, cardiac) (Q8AVB1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Troponin C, slow skeletal and cardiac muscles
- Troponin C, slow skeletal and cardiac muscles
- Tropomyosin 2
- Tropomyosin 3
- Troponin C, skeletal muscle
- Troponin I type 1a
- Fast muscle troponin I, tandem duplicate 4)
- Troponin I4b, tandem duplicate 2.
- Tropomyosin alpha-1 chain
- Troponin I type 1b
Sequence:
MCDTEEFVAEFEEEVKEQEAEEEEEAEEEVKEEAEEKEEVEEEQEEAEEGDEPEETHQEEADDEHEAEEDTKPKPKMFVPNIIPPKLPDGEKVDFDDLHRKRVEKDFNELQSLINLHFTTRQKEEDELVALKNRIERRRTDRADQQRIRTERDRERQARLAEERARREEEAAKLRAEEDARKKKILSNKGYGGFLQKVDQKKGKKLTEREKKTKCLLERRKPLNIDHLNQEKLGEKALDLWKWLNQLHAEKFELGEKLKSQKYEIKVLRNRVSDHQKGTKVAKTTRKSWK
Protein: Protrudin (Zinc finger FYVE domain-containing protein 27) (F1QVN6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, growth cone membrane {ECO:0000256|ARBA:ARBA00004460}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004460}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004195}.
Interaction partners:
- DNA topoisomerase I mitochondrial.
- Spastin
- Receptor expression-enhancing protein.
- Atlastin-1
- VAMP-associated protein B and C
- PDZ domain-containing 8
- WASH complex subunit 5
- StAR-related lipid transfer protein 3
- ADP-ribosylation factor-like 6 interacting protein
- IST1 homolog
Sequence:
MQCSASSPQEPPQASAERPELTQLPTKDPSCADSASDPGSPKALTFDLLNMVICFKRMLIFLEPITDTLEVLRYLLGWKMPLFSLLSCVLLNILFLTLTEGSWFSLLLLAISAPAVLGFLGDRCQGASSEMALQKKKHYAVQRRDLQTVHMSKQEAMLEVKGMLKQIDDLLTQACVYAESVYKVLYWESHAVSSMFYGFLLTAVCLLYTAPVGVSLSVINSALFLWNRDFCRVLLKLKEFVHPTYVEPVEETELCDSDQANLLERTPTPTSVEDLSPGNIEEAEEAEPDDEFKDAIEDDEDVSSGVPEFDTVSDNGLLSRNEPIRSKVSKLTEKLRKRVPTNATGNCVQCNSAFSVLKKRRNCSNCGISFCSRCCSYKVFRSTMGATAPEAQRETVFVCSTCNTFLSTK
Protein: Oxidative stress response two-component system protein SSK1 (Q5AKU6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to oxidative stress and probably also to the osmolarity of the extracellular environment. Involved in cell wall biosynthesis, hyphal growth, and virulence. Regulates the expression of CHK1, as well as of a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Provides at least partial adaptive functions for the survival following encounter with human neutrophils.
Interaction partners:
- Phosphorelay intermediate protein YPD1
- MAP kinase kinase kinase
- Mitogen-activated protein kinase HOG1
- High osmolarity signaling protein SHO1
- mitogen-activated protein kinase kinase
- Transcription factor SKN7
- mitogen-activated protein kinase kinase kinase
- Ste50p
- Serine/threonine-protein kinase CST20
- Opy2p
Sequence:
MNFLYNNSDYSSTSHTMKSPSAYNQFPKLQASNSTAGNNNTATTATAAAAAASASASASVTPQLISPTTLTTPQNKYKRGGLDNTLPKIETTRKNRPDDGNSITPSNSINSGTTKLTLPPRRVWVKKPQTNNPTTVLCYVNDIIDDLKVAVVNKYPNTIGRYEDAADLLVKIDLNNIRVPVSPSVNRVSQRTPFDNCIILEPDQNVWQILDNYFPNGMAMHDALIIETPTFKPDHQMLTPITANMNNNSNTFIPFQERQSSIGNNNNNNSNVNNNNKAQAVKHPQPMQPNNTRVGLHKSYAMNRSSFSTNNNPVPSIIKDRSVSPSNLGVSRNSPVSHKRSYSNPVSSPNSVATQANNPSAVLLLPRNFSLANNNSNQASQSSGGTPAKKVLSEDGSKSVNDKTEEVVSSKLKPNDNNKSYQAKQQEQQTAEQSENGFSETSASPEAVHNSKAAPLPLTKSSTTATTTSSNSISNNNNTSSKGKPSQSKLKAANDPTPTDIVLPSISVLVVEDNAINQAILGAFLRKRKIHYQIAKNGQEAIDKWKKGGFHLVLMDIQLPVKSGIEATKEIRHLEKLNRIGVFHENEIGKNVIINEEDRLTSNTFRSPVIIVALTASSNSSVDKTNALTAGCNDYLTKPVNLVWLQNKITEWGCMQALIDFDGWKDKNRRLNKA
Protein: Uncharacterized protein YidR (P31455)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Probable phospholipid transport protein YdbH
- D-galactonate dehydratase
- Galactonate operon transcriptional repressor
- 2-dehydro-3-deoxygalactonokinase
Sequence:
MAGPVLYQDRAMKQITFAPRNHLLTNTNTWTPDSQWLVFDVRPSGASFTGETIERVNIHTGEVEVIYRASQGAHVGVVTVHPKSEKYVFIHGPENPDETWHYDFHHRRGVIVEGGKMSNLDAMDITAPYTPGVLRGGSHVHVFSPNGERVSFTYNDHVMHELDPALDLRNVGVAAPFGPVNVQKQHPREYSGSHWCVLVSKTTPTPQPGSDEINRAYEEGWVGNHALAFIGDTLSPKGEKVPELFIVELPQDEAGWKAAGDAPLSGTETTLPAPPRGVVQRRLTFTHHRAYPGLVNVPRHWVRCNPQGTQIAFLMRDDNGIVQLWLISPQGGEPRQLTHNKTDIQSAFNWHPSGEWLGFVLDNRIACAHAQSGEVEYLTEHHANSPSADAVVFSPDGQWLAWMEGGQLWITETDR
Protein: (2S)-methylsuccinyl-CoA dehydrogenase (MCD) (EC 1.3.8.12) (D3JV03)
Organism: Cereibacter sphaeroides (Rhodobacter sphaeroides)
Function: Involved in the ethylmalonyl-CoA pathway, a new acetyl-CoA assimilation strategy that operates in a number of bacteria and replaces the glyoxylate cycle. Catalyzes the oxidation of (2S)-methylsuccinyl-CoA to yield mesaconyl-(C1)-CoA. Highly specific for (S)-methylsuccinyl-CoA.
Interaction partners:
Sequence:
MTGQPLLGDLLTLASDALPEVEALFETARSALKERVTTDGKVSSKALEEEQFAAHALSWLATYVESLRQMRAWAGRLETEGRFGEMEALILQIAFGEYLAQIRGGIPMSQTETARVQDIGIELGHPGEAVRRLIQAGNTPAARARLVALMRDNHGRATFGASGLDEELEMIRDQFRRFADERVAPHAHGWHMRDELIPMEIVEALAEMGVFGLTIPEEFGGFGLSKASMVVVSEELSRGYIGVGSLGTRSEIAAELILCGGTDAQKAAWLPKLASGEILPTAVFTEPNTGSDLGSLRTRAVKDGDEWVVHGNKTWITHAARTHVMTLLARTDLETTDYRGLSMFLAEKVPGTDADPFPTPGMTGGEIEVLGYRGMKEYEIGFDGFRVKAENLLGGVEGQGFKQLMQTFESARIQTAARAIGVAQNALEVGMQYAEERKQFGKALIEFPRVAGKLAMMAVEIMVARQLTYHSAWEKDHGQRCDLEAGMAKLLGARVAWAAADNALQIHGGNGFALEYQISRILCDARILNIFEGAAEIQAQVIARRLLD
Protein: GPCR-type G protein 2 (F4JJP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGYGWGIFEGMLVIGSLCLLGSAGLWFLNRRLYKEYEEKRALVQIIFSVVFAFSCNLLQLVLFEIIPVLSREARMVNWKVDLFCLIVLLVFMLPYYHCYLMLRNTGVRRERAAVGALLFLTAFLYAFWRMGIHFPMPSDKGFFSMPQLVSRIGVIGVTLMAVLSGFGAVNLPYSYISLFIREIEESEIKSLERQLMQSMETCIAKKKKILLCQVEVERSLVSEEHQKGKSFFRRFVGTVVRSVQDDQKEQVQLVYCWDNKVVELLQFSPCCQIIDIKLMEAEVEGLEELSKQLFLEIYELRQAKDAAAFSRTWKGHVQNFLGYACSIYCVYKMLKSLQSVVFKEAGTKDPVTMMISIFLQFFDIGVDAALLSQYISLLFIGMLIVISVRGFLTNLMKFFFAVSRVGSGSSSNVVLFLSEIMGMYFLSSILLIRKSLRNEYRGIITDVLGGDIQFDFYHRWFDAIFVASAFLSLLLLSAHYTSRQIDKHPID
Protein: 6-phospho-beta-glucosidase BglB (EC 3.2.1.86) (Phospho-beta-glucosidase B) (P11988)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the hydrolysis of phosphorylated beta-glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glucosides (p-nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin and phosphorylated salicin), and a low affinity for phosphorylated beta-methyl-glucoside.
Interaction partners:
- PTS system beta-glucoside-specific EIIBCA component
- Cryptic beta-glucoside bgl operon antiterminator
- PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component
- Periplasmic beta-glucosidase
- PTS system N,N'-diacetylchitobiose-specific EIIB component
- PTS system N,N'-diacetylchitobiose-specific EIIC component
- PTS system N,N'-diacetylchitobiose-specific EIIA component
- 6-phospho-beta-glucosidase
- Glucokinase
- 6-phospho-beta-glucosidase BglA
Sequence:
MKAFPETFLWGGATAANQVEGAWQEDGKGISTSDLQPHGVMGKMEPRILGKENIKDVAIDFYHRYPEDIALFAEMGFTCLRISIAWARIFPQGDEVEPNEAGLAFYDRLFDEMAQAGIKPLVTLSHYEMPYGLVKNYGGWANRAVIDHFEHYARTVFTRYQHKVALWLTFNEINMSLHAPFTGVGLAEESGEAEVYQAIHHQLVASARAVKACHSLLPEAKIGNMLLGGLVYPLTCQPQDMLQAMEENRRWMFFGDVQARGQYPGYMQRFFRDHNITIEMTESDAEDLKHTVDFISFSYYMTGCVSHDESINKNAQGNILNMIPNPHLKSSEWGWQIDPVGLRVLLNTLWDRYQKPLFIVENGLGAKDSVEADGSIQDDYRIAYLNDHLVQVNEAIADGVDIMGYTSWGPIDLVSASHSQMSKRYGFIYVDRDDNGEGSLTRTRKKSFGWYAEVIKTRGLSLKKITIKAP
Protein: Actin-like protein, putative (Q57ZL0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Actin-like protein 2, putative
- Cofilin/actin depolymerizing factor, putative
- Uncharacterized protein
Sequence:
MDATCVIDYGSHTVKHTCISKADKNSAFEFNINEAPTQAFAANDSLDIVLFGRHVAELISDTCPAGSALTLCLLTDTWLPRRKRELLLKCCFECLGAKRVSLVDSVSTALFSSGETTGVCVDVGYGGVRAVPVVNGFPQSFLGEDVRSVGAKNTDTVLRRHIPQASEPVLLALKSTVCFVGDEPPAVSRQISLPDGSTFPMTLSPSVCREAGEALLYNAPTASAPNALRHMYQKSLLECPSLDRWVLVGAASGMTGVGRVLGEAMTHALTVTQREGPQYIAVKDPAHAAVCGGAILSQLSTFKKMCVTVEEYVEEGPHYCVRPKII
Protein: PDEase domain-containing protein (Q57Y10)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSQKHIFQRPSMACEQVVGTAAVGTAVASPGSPAPAFDALQRISSLRRSLSNVVASRALSLDRSNTPNPRMPPDTDGLQESTARQLLASSQRRVEELLRENHKLELLCMKQEDTIKEIQIEMTLNKKKEDEPAGNVADNAPGEPPNISQTHSISYKSRGPGTKSKAGRAPDNDGGDIAEAHDGTHRSPSVLAELDEVVQQLVSTAIALFPELEARAESASRDGADEWSVARDIIHFIESHLEEWSDHASQENVDIGEASAMLSQTLTSVEEDQHEWGKSLFDLANRLQMAWSEQRHAITKRDFLISKLKKNIKSLSTELSDAVEVRMQCECRCAELEGALSRMMENHVEHDANVQRLQQECNNLRSETNALLALAGQEGTAAANSSNAGRDLDGISDSDMTKATENGAQSTTADRDAELLRHALERVTKERDQLQVQLDVANDALKGAELRANVTKAEREAVFSNINEPQCSDVAVAANPAAVVRFSQNSADEAMMPLHGPLLSRSWNADDKTCDTTVTPNINLLRIIGDIDADIWSEKNCGASEQGGLLFQVGCAIAQDSELFDGMPEPDLSLTAWKRLLLHIQNGFGSGPFHSADRAADNMQFFYSLMFHSGMLERMTPVERIATTTSALCAMYRYVVPPSETHKSSDAQLRDVASVYPNSLEKEMLESYCNYETICRLMGRCYFNFSAHWEAKDRDLLLRTMRALLLPQESLSQLECLIYAGDIERADGISPRLHAAPVRHQFVRLFIALAQHAFTMRTAAVSRYWASERFGLYQRQTQFINEPSVRPVEVPYNTRMVAEAQLLLINTTVLPLCQTAVRVFPRLQPCLVALQGNLCMWTLCNSDHGDVPPSSIALPPEMKVTPSIPEKNILCKDFGFRLVATEGVTPGTVTLDTAGFISTQDEVSALYKENAMLRGLLNRLFSEMDVPLECTESSQISGG
Protein: NPC intracellular cholesterol transporter 1 homolog 1b (Niemann-Pick type protein homolog 1b) (Q9VRC9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking.
Subcellular location: Cell membrane {ECO:0000305|PubMed:17339027}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Niemann-Pick type C-2e
- GEO07678p1
- NPC intracellular cholesterol transporter 2 homolog a
- Niemann-Pick type C-2c
- Niemann-Pick type C-1a, isoform A
- GEO08227p1
- Niemann-Pick type C-2g, isoform A
- LP12374p
- Sphingomyelin phosphodiesterase
Sequence:
MKVIFATIWLIAGAWSQSAEQLGCIWYGQSHMIGAHWVNKGDTNPARPLNSPTSEAIFAKRCPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFLTAYNDTNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDVSGDYVPFQINYKWSEDAEEGSNEIYLDLSPLKCGESYEDSYACACIDCEESCPLTDAPTGPDELWKIAGLYGVTFILALIIACALSFFIFWGAFGKTSAPSVCMPTLFGEFFYHGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHETSNGVLNFGPAFEYNFLKEVFELQDSIMKLGMADNEGLDKICYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVDSNNYTINYLNQLEDCLRVPMMEDCFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLGRNYNDESKLEPNMKWEKLFVDFLRDYKSDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEVGLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDWLAISDCCKYNVTTGGFCSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFKRAEGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGPPQKLARSSGAEPTASITITTN