wanglab/gogpt-training-data huggingface dataset:
Protein: 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit rpn-2) (Q18115)
Organism: Caenorhabditis elegans
Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- Probable 26S proteasome regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 2
- 26S proteasome non-ATPase regulatory subunit 7
- Probable 26S proteasome regulatory subunit 10B
- 26S proteasome regulatory subunit 7
- 26S protease regulatory subunit 6A
- PCI domain-containing protein
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 3
- Probable 26S proteasome regulatory subunit 6B
Sequence:
MLTLLNRWRSQPGGASNAAAFIRVLESPKSAVTDKVLVLKAFNDWDVLVNTWFEVADALPAVEQLLDNNTFPEHSSAALLVSKVYFCLEQYERALEFALRGDFNVVPATRTGLGNDAEYVNKIIETAIDTYKTLSKQGSGIPQKLRDLIDRIVARNLDKREIWFVISLGFETTNLAMIDRAISAMPADLTIKNQTTLVETLNRVVNGAFDRSFRFQVIDTVIKTYLKCPSPDMSKICECYVLTDNAEAAADTITSLIAKSLSTRAYQIAFDLYETASQGFLDRVLKRFQQQDARDEKSMEKIHSILKGHETVKAYLDFFVRHNHTDSVLMEEIKENIRTASAHNALLISNGLMQYGTTCDDFLRNNLNWVSKATNWNKFNAVASLGLIHHGQESSAMKVLEPYLPKESVEGFGFKEGGAMLAYGLIHAKHGDATAMSTLAQWLKTAENEPVRHGACLGFGVAGLGSSSVSNYEKVREVLQRDEAVSGESAGIAMGLIMAGHLNQEVFNELKQYTVDTQHDKTQRGIRTGLACAAFGLQGDAEPYIKEAIGAKSNPMLRSTGICMLSMAYAGTGSPDVVRRLLEKVATDPNLDVKRYATIGIGFVLSKDPSTCLSYVAMLTEHFNGHVRYGAAMALGIACAGTGNMEAIALIEPMISDKEGFVRKGALLSLALIMCQQTDYTCPKVNGFRKQLLKKIGEKNEDSLVKFGAIIAQGLLDIGGQNAAVTMQNSDKQPDMGSMVGMMCFLHGWFWHSMHFFIALAAKPSCLVMMNENLKIPVLDYICHANSQKFAYPPRAESKKDKDVKKIETVVLSITGKKNASKKLIAEEKKRREAAASASSAAAAPSSSSTSGTAPAAEDEKMEVDQPGKSKKEKAPEKDTKPLHRLQNPARVIPAQRQLISISDARAYSPMKPLYKGGIIVADRVDKEREEKLVSEVVTQVNTPASSGNTENKPHSTFEININDF
Protein: Zinc finger and SCAN domain containing 4B (E9Q3G0)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
Interaction partners:
- Zinc finger and SCAN domain containing 4E
- Eukaryotic translation initiation factor 4C
- TD and POZ domain-containing protein 1
Sequence:
MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQSATRPIPDNAQMPVDTTQDRLLATGQENSENECNTSCNATEVNVGESCSGNEKDSLLITQKEQNHEHEEGNVVCQFPRGARRASQDTSSHHVDFPSALTPADVPMEEQPMDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKTDSLFINKRIYHPEPEVGDIPYGVPQDSTRASQGTSTCLQESLGECFSEKDPREVPGLQSRQEQPISDPVLGKNHEANLPCESHQKRFHRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCITCQKIFKRVSDLRTHEIIHMSEKPFKCSTCEKSFSHKTNLKYHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD
Protein: Steroid hormone receptor family member cnr14 (Nuclear receptor subfamily 1 group G member 1) (P41830)
Organism: Caenorhabditis elegans
Function: Transcriptional regulator which is involved in the sex determination and X chromosome dosage compensation pathways. Directly binds to five 5'-A(G/C)(G/T)(T/G)C(A/G)-3' sites in the promoter of sex-determining factor xol-1 to negatively regulate its expression and promote hermaphrodite development. Together with fox-1 is involved in making the distinction between one and two X-chromosomes. Plays a role in the fox-1-mediated repression of the functionally active isoform (isoform b) of the sex-determining factor xol-1 gene to promote hermaphrodite development. Plays a role in the association of the dosage compensation complex proteins dpy-27 and sdc-3 with the hermaphrodite X chromosomes.
Subcellular location: Nucleus {ECO:0000305|PubMed:23666922}.
Interaction partners:
- XO lethal protein 1
- Sex determination protein fox-1
- Nuclear receptor corepressor 1
- T-box transcription factor 18
- Homeobox protein ceh-39
- RNA-binding protein ASD-1
- Sex determination and dosage compensation protein sdc-2
- Signal element on autosome protein 2
- Protein her-1
- Zinc finger protein sdc-1
Sequence:
MSFETKPNYLLLTNPDTPLSVCTSPYYSPSGKTASIPSSEASKPEGTNGQWSHLPTGATYVTDEFSSEFQIQNGSTAAQSGNANNYADPLSHRRYFNNVNGYNHHQFYDTASQASVSSPATSVTSSLSPPDSLSNGHTTQRHHIGKAISFCKVCGDKASGYHYGVTSCEGCKGFFRRSIQRKIDYRCLKQQVCEIKRESRNRCQYCRFKKCLDSGMSKDSVRQMKFRNAMRDDKSPDSVFVPEISTLERQEEVDAVYEAVLRAHTTFSFYTDIKIRSIVARPFNVRINEDSKMNRLNAWQIYAHEIDVDIKEVVNFVKEIPKFNFINGNDKAVLLRKNAFPLYLLRIVRGMSNRGLMLRDGRLIDFKSLQLLYGSLADEMLAFANHIITIGCTDGDIALFIVLILCQPLTTEQQFSTNFKSQLQLLEMFDFYKKVLFQKMTCRIDGCDTYKQLMKCIHELNRLNELHKQQLNILRENLSFLNLPPLVVEMFQLSTLPLPVNHNNQENQYTPAPEHQSPQPQQPTPNQQQTPVHC
Protein: Upstream activation factor subunit UAF30 (Upstream activation factor 30 KDa subunit) (p30) (Q08747)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Nonessential component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level. UAF30 seems to play a role in silencing transcription by RNA polymerase II.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- RNA polymerase I-specific transcription initiation factor RRN5
- RNA polymerase I-specific transcription initiation factor RRN10
- RNA polymerase I-specific transcription initiation factor RRN9
- RNA polymerase I-specific transcription initiation factor RRN6
- RNA polymerase I-specific transcription initiation factor RRN7
- RNA polymerase I-specific transcription initiation factor RRN11
- Histone H3
- Histone H4
- Uncharacterized protein YPR153W
- Mitochondrial acidic protein MAM33
Sequence:
MAELNDYSTMIDILLSDMDLETVTTKKVRMALKEVYAIDVESQGKAINKLIRKHLDLVKERPRFERSLEDLLKENATLAIELTKEITVSKRSSGEEKNDSETKGTHVEKKKGTVSKSPISTRKVTLSKSLASLLGEHELTRTEVVRRLWAYIKAHNLQNPNNKKEILCDEKLELILGKSTNMFEMHKILASHMTEPKKISDCPPLIQEVRRKEKPIVSDSEQSDTKGI
Protein: Target of rapamycin complex 1 subunit mip1 (TORC1 subunit mip1) (P87141)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10648609, ECO:0000269|PubMed:18076573}.
Interaction partners:
- Target of rapamycin complex subunit wat1
- Serine/threonine-protein kinase tor2
- Serine/threonine-protein kinase tor1
- Target of rapamycin complex 2 subunit ste20
- GTP-binding protein gtr1
- Target of rapamycin complex 2 subunit sin1
- Serine/threonine-protein kinase sck1
- GTP-binding protein gtr2
- Serine/threonine-protein kinase atg1
- Uncharacterized protein C63.05
Sequence:
MNDRISEVSGSSRARRSVLSYGTTETGSDRYTENSNIATENGVDTASSMIDGIQSGFPQPRHGFEEEYNNAEYINMLEQVFYMYYTDKRHRGVISKKNAEPTETIHDWRMRERLKTVSAALLVCLNIGVDPPDVIKPNPAAKYECWIDPFSLPASKALEAIGKNLQQQYETLSMRTRYRHYLDPAIEEVKKLCIGQRRNAKEERILFHYNGHGVPMPTASGEIWVFNKNYTQYIPVSLYDLQSWLGAPCIYVYDCSAAGNIIVNFNRFAEQRDKEALRIAKQNPNVLAMPSHTSCIQLAACGPKETLPMNPDLPADLFTSCLTSPIEISVRWYVLQNPFPNKLNLNMLLKIPGRLQDRRTPLGELNWIFTAITDTIAWNVFPKHLFRRLFRQDLMVAALFRNFLLAERIMLVHSCHPQSSPELPPTHDHPMWNSWDLAIDNCLSQLPDMLDAESKGIAYEYKHSTFFSEQLTAFEVWLSQGLISRKPPDQLPLVLQVLLSQVHRLRALILLSKFLDLGVWAVDLALSIGIFPYVLKLLQSPAIELKPVLVFIWARILAVDDSCQADLLKDNGYGYFVQILNPNSSIFPSSNISEHRAMCAFILSVFCRGFPQGQLACLNPQVLSHCLSHLNSPDSLLRQWACLCISQLWENYSEAKWSGTRDNAHVKLAEIIVDSVPEVRASVLTAFTTFLGFPEKTEEVVAVETYIAIAALAALSDASPLVRHELVIFLSHFVVNYKKQLMVVAYESSLADILEKKNHNSISASTIYETVWQAVLVLAADPSIEISLAAEAIINYVYQSMLNSELRESFLAFLLQHLPALHKASLSKDTDTNSVTSDPKPHPFVPSVSENKILNRSFSLTRSLKGLALSLAGSDRASELLSLNGENKPAESNLNHLTSAKVPGPPAFNELEYQSELDMPLTSYLFDWSRKYFTEPQMRPNEDDEPGSICYNQRLWRRNRNEKLIYRTRPLAEYSTNGRWNQQLMTFNNTIAPRKLMFHQFEDQLITLGDKDIIQVWDWRRNRCLNSFKTSASATTNVTDMQLLNEDDVALLMTGSSDGTIKLYRDYENEKVELVTSWNSLSDLVFGDRNASLLMSWQQNCGHLLVAGDVRVIRIWDASKEICYANLPVRSSNSITSLTSDLVGCNIIVAGFSDGVLRVYDKRLPARDSLTDVWKEHSSEIVNVEMQSSGMRELISASSDGEVKLWDIRMNHSLQTFSTDNSGLTSLTVHSHAPVYATGSSNQSIKIWDTLGQNINTFRENPRFLNQPKPSSLMCLKFHPHHLLLACGDNTDSRVNLYSCTKNEIHTDSPNEF
Protein: CaeNaCin (Caenorhabditis bacteriocin) (O44614)
Organism: Caenorhabditis elegans
Interaction partners:
- CaeNaCin
- CaeNaCin
- Neuropeptide-Like Protein
- Neuropeptide-like protein 31
- CaeNaCin
- CaeNaCin
- CaeNaCin
- AntiBacterial Factor related
Sequence:
MLRFTCILLLAMLALASAQWGYNSYGGYNSYGNYGGYGGGYNNGYGVNANLGVGGRGGGLVGGLLGRK
Protein: Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (Histone H3-K79 methyltransferase) (Q5YL88)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU271113}.
Interaction partners:
Sequence:
EYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAASAERKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTQLHSPNPLLVAPTPPALQKLLESFRIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFGHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEADAGRLRLELDCAKISLPHLSSMSPELSMNGHAASYELCNAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHPKESSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSEKGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSATLEKQTGASAHGAGGAGAGSRSLAVAPTGFYAGSVAISGALASSPAPLASGMESAVFDESSGPSSLFATMGSRSTPPQHPPLLSQSRNSGPASPAHQLTASPRLSVTTQGSLPDTSKGELPSDPAFSDPESEAKRRIVFSISVGASSKQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLSTGVSPKRRALPTVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGLTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGVFTHAVPSASAHPFGAGVGSGAVCSSATLGLSPLQAAASTSASSFQAAASVETRPPPPPPLLPPQHLGRPPAGPPVLHAPPPPNVALPPPPALLASNPEPVLLQSLASLPANNAFLPPSSAASLQPANASLSVKLASLPHKVSRPSFTVHHQPLPRLALAQAAPAAPQASTSGPSAVWVSLGMPPPYAAHLSGVKPR
Protein: Exonuclease V (Exo V) (EC 3.1.-.-) (Q9Y7L4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity).
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:31563844}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:31563844}.
Interaction partners:
Sequence:
MEEYEDFEMEDLSELVSYMDYLETQRLTISQLDYSLSIPPQLLVSREISKLEDEVCEMLKESSLFQLFRKHKGYLNVTDLVLPLWCEVQHEYYLLRRIKKKTPKMERGIKLHQILEYETSPPSERRVLDRTSKEEPWALRLLRQLEGIMLLQKNGITREFPIWGYYKESSIFGIIDEISLNNPSKSNFNSDIRNYFNFKMYDLSFVDNKTRFSSRKPGASQILSSKVQLMYYVHLFLNYFPSLGEKQQSIFRDISPTYSNRLHSQSHWWNMFLSQLSLDGTKDLGPKFLEQSILSIPDIPEDVFAGHNSLNGLYALVFASAKKLHLRLTDDNLTIAYRNDKTGEVVYKDKFSFSNKLLEASYTKAYQFWHNLREPEGVPAEEVYKCRSCEFQKECWWLKKKQYYPLSSP
Protein: Uncharacterized HTH-type transcriptional regulator Rv1395 (P9WMJ1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Putative cytochrome P450 132
- Probable monoxygenase
- HTH-type transcriptional regulator RipA
- Probable transcriptional regulatory protein
- Probable transcriptional regulatory protein
- AB hydrolase-1 domain-containing protein
- HTH-type transcriptional regulator Rv1931c
- HTH-type transcriptional regulator VirS
- Transcriptional regulatory protein
- Probable transcriptional regulatory protein
Sequence:
MGHLPPPAEVRHPVYATRVLCEVANERGVPTADVLAGTAIEPADLDDPDAVVGALDEITAVRRLLARLPDDAGIGIDVGSRFALTHFGLFGFAVMSCGTLRELLTIAMRYFALTTMHVDITLFETADDCLVELDASHLPADVRGFFIERDIAGIIATTTSFALPLAAKYADQVSAELAVDAELLRPLLELVPVHDVAFGRAHNRVHFPRAMFDEPLPQADRHTLEMCIAQCDVLMQRNERRRGITALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRLAEEGTSFRALLGEARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFKRWYGVAPSEYSRRG
Protein: Transmembrane protease serine 11C (EC 3.4.21.-) (Neurobin) [Cleaved into: Transmembrane protease serine 11C non-catalytic chain; Transmembrane protease serine 11C catalytic chain] (Q1JRP2)
Organism: Mus musculus (Mouse)
Function: Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18215125}; Single-pass type II membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:18215125}. Perikaryon {ECO:0000269|PubMed:18215125}.
Interaction partners:
Sequence:
MARGQPRRSEEQWTALQNRTECKTKIKLTRCGKITLGILTAVLAAVLIGLIAYFAACGKDSFYYHVSFKVNNIDYDSKFAKPYSQEYMDLNKRIVSLMNETFHESKLRKQYVKAHTVQVSKAKGKVVIHAVLKFKACYRNNVEKYWESVETTLYQKLKGQTGLLIDSSSFKFSDIAMPIAEDLLNTCCGRRTIIHRGHKVAGGQDAEEGEWPWQASLQQNSVHRCGATLISNYWLITAAHCFIRAANPKDWKVSFGFLLSKPQAPRAVKNIIIHENYSYPAHDNDIAVVRLSSPVLYESNIRRACLPEATQKFPPNSDVVVTGWGTLKSDGDSPNILQKGKVKIIDNKTCNSGKAYGGMITPGMMCAGFLKGRVDACQGDSGGPLVSEDSKGIWFLAGIVSWGDECALPNKPGVYTRVTYYRDWITSKTGL
Protein: Acylamino-acid-releasing enzyme (EC 3.4.19.1) (Acyl-peptide hydrolase) (Acylaminoacyl-peptidase) (C9JIF9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MERQVLLSEPEEAAALYRGLSRQPALSAACLGPEVTTQYGGQYRTVHTEWTQRDLERMENIRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTMKAVLRKAGGTGPGEEKQFLEVWEKNRKLKSFNLSALEKHGPVYEDDCFGCLSWSHSETHLLYVAEKKRPKAESFFQTKALDVSASDDEIARLKKPDQAIKGDQFVFYEDWGENMVSKSIPVLCVLDVESGNISVLEGVPENVSPGQAFWAPGDAGVVFVGWWHEPFRLGIRFCTNRRSALYYVDLIGGKCELLSDDSLAVSSPRLSPDQCRIVYLQYPSLIPHHQCSQLCLYDWYTKVTSVVVDVVPRQLGENFSGIYCSLLPLGCWSADSQRVVFDSAQRSRQDLFAVDTQVGTVTSLTAGGSGGSWKLLTIDQDLMVAQFSTPSLPPTLKVGFLPSAGKEQSVLWVSLEEAEPIPDIHWGIRVLQPPPEQENVQYAGLDFEAILLQPGSPPDKTQVPMVVMPHGGPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGSTGFGQDSILSLPGNVGHQDVKDVQFAVEQVLQEEHFDASHVALMGGSHGGFISCHLIGQYPETYRACVARNPVINIASMLGSTDIPDCSVSCRCVVEAGFPFSSDCLPDLSVWAEMLDKSPIRYIPQVKTPLLLMLGQEDRRVPFKQGMEYYRALKTRNVPVRLLLYPKSTHALSEVEVESDSFMNAVLWLRTHLGS
Protein: Succinate dehydrogenase subunit 5, mitochondrial (Q9SX77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Succinate dehydrogenase subunit 7A
- Succinate dehydrogenase subunit 7B
- Succinate dehydrogenase subunit 8
- Succinate dehydrogenase subunit 3-1
- Succinate dehydrogenase subunit 3-2
- Succinate dehydrogenase flavoprotein subunit 1, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 2, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 1, mitochondrial
- Succinate dehydrogenase subunit 4
- Succinate dehydrogenase subunit 6
Sequence:
MGTLGRAIHTVGNRIRGTAQAQARVGSLLQGSHHIEKHLSRHRTLITVAPNASVIGDVQINKGSFISYASVSRDLQYPRAMGMGQVRRFSEDVSHMPEMEDSDVLNAFKDLMAADWAELPSAVVKDAKTAISKNTDDKAGQEALKNVFRAAEAVEEFGGILTSIKMEIDDSIGMSGEGVKPLPNDITDALRTAYQRYAEYLDSFEPEEVYLKKKVEMELGTKMIHLKMRCSGLGSEWGKVTVLGTSGLSGSYVEQRA
Protein: Vesicle transport protein USE1 (USE1-like protein) (Q9VSU7)
Organism: Drosophila melanogaster (Fruit fly)
Function: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (By similarity). Required for protein secretion.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16452979}; Single-pass type IV membrane protein {ECO:0000269|PubMed:16452979}.
Interaction partners:
- Syntaxin-18
- Secretory 22, isoform B
- LD34211p
- RINT1-like protein
- Centromere/kinetochore protein zw10
- Syntaxin-5
- BET1 homolog
- IP18173p
- Probable Golgi SNAP receptor complex member 2
- Golgi SNAP receptor complex member 1
Sequence:
MATKLNVNIRTLLANCEELAKSEQNFWRLQKFIKSLDTMLAELEAMGDPQSVKRIPGYLERLQALKISTGYADVPGSTTKTPSQSSAVSETGENALKEIRQLQNSKYHNELRKELLQDSDALRRRRGADESSSSSGSANVQETSGENMNQAAKYYTNAQEKITEHMLSLTRNLKEQTETANRIIRRDTEVVSRSAGMADRNINSLGKEAEKLEQHSKKAYKCWLWLMIAFVIATFIGMVLFMKIMKKKKS
Protein: Uncharacterized protein C4G9.04c (Q10237)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- mRNA 3'-end-processing protein rna14
- Uncharacterized RNA-binding protein C644.16
- RNA polymerase II subunit A C-terminal domain phosphatase ssu72
- Protein cft1
- Endoribonuclease ysh1
- Cleavage factor two protein 2
- mRNA cleavage and polyadenylation factor clp1
- mRNA cleavage and polyadenylation specificity factor complex subunit pta1
- UPF0400 protein C337.03
- Poly
Sequence:
MDLVELDYLSALEDLTFNSKPIIHTLTYIAQENEPYAISIVNAIEKHIQKCPPNCKLPALYLLDSISKNLGAPYTYFFGLHLFSTFMSAYTVVEPRLRLKLDQLLATWKQRPPNSSSLEPVFSPIVTAKIENALLKYKSTILRHQSPLLANTSISSFSAPIDANINSYSSFSDPASSYKPSLPSVPFGFQHISGTSPSPGFITLDSLLSDVNRMIVTEQARFIKNPYDNMAKKRFEILLQLKNVLSSSALPYDQLLAIKNQLAQLEKPASPSTSSVATSAPSVPSALSSISSTPFMKPSIPSTIPTIPSAYSASVSSQPPLTHSYVHPGPQSHKYSLSSGPPASLYNANALTPEESSSIDSLFANLQAAGLVPPSAGGKSQGPQASCTEAVSLTADIDLSKSSLATPRPKLSSLLYENYSNQCANCGRRYGNDPESRKELDKHSDWHFRINKRIRESSLHGINRCWFVMEEEWVNSKEEEDLITETAQEIEEQRQKQMESVRSQYVLTPLDPIAASEPCPICQEKFQSVWHEEAEVWVFMNAVEEEGRIFHATCLQEVRPSENKHSNTNTSTQNLAEAAVSSNIKNATGDASKDSQPDVQNLLQGIDIQSILQALGKRKERDDSMDSMSSKVIKQESK
Protein: Cytochrome P450 CYP107DY1 (EC 1.14.-.-) (Mevastatin hydroxylase) (D5E3H2)
Organism: Priestia megaterium (strain ATCC 12872 / QMB1551) (Bacillus megaterium)
Function: Cytochrome P450 whose physiological substrate is unknown. In vitro, is able to catalyze the selective hydroxylation of mevastatin to pravastatin, the widely used therapeutic agent for hypercholesterolemia.
Interaction partners:
Sequence:
MKKVTVDDFSSPENMHDVIGFYKKLTEHQEPLIRLDDYYGLGPAWVALRHDDVVTILKNPRFLKDVRKFTPLQDKKDSIDDSTSASKLFEWMMNMPNMLTVDPPDHTRLRRLASKAFTPRMIENLRPRIQQITNELLDSVEGKRNMDLVADFSFPLPIIVISEMLGIPPLDQKRFRDWTDKLIKAAMDPSQGAVVMETLKEFIDYIKKMLVEKRNHPDDDVMSALLQAHEQEDKLSENELLSTIWLLITAGHETTAHLISNGVLALLKHPEQMRLLRDNPSLLPSAVEELLRYAGPVMIGGRFAGEDIIMHGKMIPKGEMVLFSLVAANIDSQKFSYPEGLDITREENEHLTFGKGIHHCLGAPLARMEAHIAFGTLLQRFPDLRLAIESEQLVYNNSTLRSLKSLPVIF
Protein: Chitin deacetylase 8 (BmCDA8) (EC 3.5.1.41) (Chitin deacetylase 17) (H9JW43)
Organism: Bombyx mori (Silk moth)
Function: Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine (GlcNAc) residues in chitin. Shows activity towards the chitinous oligomers GlcNAc(3), GlcNAc(4), GlcNAc(5) and GlcNAc(6), but not GlcNAc or GlcNAc(2). Requires the substrate to occupy subsites 0, +1, and +2 for optimum catalysis.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MKRLSVLCSLLLVAAALGTELPLATPCDEEACKLPDCRCSSTNIPGGLRARDTPQFVTVTFDDGINVINIETYREVLYGRSNSNRCPAGATFYVSHEYTNYQLVNELYNRGFEIALHSISHRTPQAFWADATYQNLVQEIGDQKRQMAHFASIPASAIKGVRIPFLQMSGNTSFQVMADFDLLYDCTWPTTALTNPGLWPYTLHHESIQDCIIPPCPTASIPGPWVLPMISWRDLNNFPCSMVDGCFFTPDRTDEEGWFKFILTNFERHYLGNRAPFGFFVHEWFISSNPAIKRAFVRFMDIINNLNDVFMVNSAEVIDWVKNPVPIDRYRQQQCKFTMPSICRPSFCGPLTGTHNQLSYYMTICNTCPRNYPWVGNPLGQ
Protein: Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] (P52655)
Organism: Homo sapiens (Human)
Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
Subcellular location: Nucleus.
Interaction partners:
- Transcription initiation factor IIB
- Transcription initiation factor IIA subunit 2
- TATA-box-binding protein
- General transcription factor IIE subunit 1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIF subunit 1
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor TFIID subunit 5
- TATA box-binding protein-like 1
- General transcription factor IIH subunit 4
Sequence:
MANSANTNTVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFHSEEQQLLLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHMNASNMSAAATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTVAAPTPAQAQITATGQQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKEKDGAEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDAEW
Protein: Transmembrane protein 234 (Q8WY98)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MAASLGQVLALVLVAALWGGTQPLLKRASAGLQRVHEPTWAQQLLQEMKTLFLNTEYLMPFLLNQCGSLLYYLTLASTDLTLAVPICNSLAIIFTLIVGKALGEDIGGKRAVAGMVLTVIGISLCITSSVPWTAELQLHGKGQLQTLSQKCKREASGTQSERFG
Protein: NuA4 complex subunit EAF3 homolog (Protein MRG15) (Q9Y0I1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- MRG/MORF4L binding protein
- DNA methyltransferase 1-associated protein 1
- Enhancer of polycomb-like protein
- YEATS domain-containing protein 4
- Chromatin modification-related protein MEAF6
- Transcription-associated protein 1
- Inhibitor of growth protein
- RuvB-like helicase 2
- Brahma associated protein 55kD
- PHD finger protein 12
Sequence:
MGEVKPAKVENYSTGTDANTLFVDGERVLCFHGPLIYEAKVLKTKPDATPVEYYIHYAGWSKNWDEWVPENRVLKYNDDNVKRRQELARQCGERSKKDNKKGSAKAKKMEQMRNESRASTPSKDSNTSQSTASSTPTTSAGPGSKSEAGSTGTTTTNSTANSTTSRAHRKSTQSTPSTARPGTPSDKKEDPAAAETTEEEGPVAPKKKRMSEQRPSLTGSDVAEKPLPPTTTPSTPTTEPAPCVESEEAYAAKVEVKIKIPDELKHYLTDDWYAVVREHKLLELPAKVTVQQISEQYLAHKKSVKSTSASKEVAINDVLDGIVEYFNVMLGSQLLYKFERTQYADVMQKHPDTPLSELYGSFHLLRLFVRLGSMLSYSALDQQSMQNLLTHVQDFLKFLVKNSSIFFSMSNFINVDPEYVRNAQ
Protein: 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) (P97288)
Organism: Mus musculus (Mouse)
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q13639}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:15466885}; Multi-pass membrane protein {ECO:0000255}. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000269|PubMed:15466885}.
Interaction partners:
- Guanine nucleotide-binding protein G
- VIP peptides
- Pro-opiomelanocortin
- 5-hydroxytryptamine receptor 6
- 5-hydroxytryptamine receptor 7
- Gastric inhibitory polypeptide
- Pro-glucagon
- Pituitary adenylate cyclase-activating polypeptide
- Natriuretic peptides A
- Guanine nucleotide-binding protein G
Sequence:
MDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQPADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPSDT