wanglab/gogpt-training-data huggingface dataset:
Protein: Probable ketol-acid reductoisomerase, mitochondrial (EC 1.1.1.86) (Acetohydroxy-acid reductoisomerase) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (P78827)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Dihydroxy-acid dehydratase, mitochondrial
- Probable acetolactate synthase small subunit
- Acetolactate synthase, mitochondrial
- 3-isopropylmalate dehydratase
- Aconitate hydratase, mitochondrial
- Threonine dehydratase, mitochondrial
- Lon protease homolog, mitochondrial
Sequence:
MSFRNSSRMAMKALRTMGSRRLATRSMSVMARTIAAPSMRFAPRMTAPLMQTRGMRVMDFAGTKENVWERSDWPREKLVDYFKNDTLAIIGYGSQGHGQGLNARDQGLNVIVGVRKDGASWKQAIEDGWVPGKTLFPVEEAIKKGSIIMNLLSDAAQTETWPKIAPLITKGKTLYFSHGFSVIFKDQTKIHPPKDVDVILVAPKGSGRTVRTLFKEGRGINSSFAVYQDVTGKAQEKAIGLAVAVGSGFIYQTTFKKEVISDLVGERGCLMGGINGLFLAQYQVLRERGHSPAEAFNETVEEATQSLYPLIGKYGLDYMFAACSTTARRGAIDWTPRFLEANKKVLNELYDNVENGNEAKRSLEYNSAPNYRELYDKELEEIRNLEIWKAGEVVRSLRPEHNKH
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (F7EXM7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEPQSRLAKGKSKRKRDLRISCVSKPPVSNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
Protein: Son of sevenless 1 (Q9Z1I1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
EERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDDIGLVSLCEEEPCSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDKKLFKSSEIEKIFSNISDIHELTVKLLGLIEDTVEMTDEGSP
Protein: ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP) (F1RBC8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (By similarity). Involved in oligodendrocyte patterning and myelination.
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisomal biogenesis factor 19.
- ATP-binding cassette, sub-family D
- Peroxisomal membrane protein PEX13
- Acyl-CoA-binding domain-containing protein 5A
- Peroxisomal membrane protein 4
- Peroxisomal biogenesis factor 3.
- Peroxisomal membrane protein 2
- Peroxisomal biogenesis factor 11 beta
- Peroxisomal biogenesis factor 7.
- Peroxisomal membrane protein PEX16
Sequence:
MSVYSKLPSQLKKPLVKKAVVLLIALYGVKKLSPYFFGKLKGRTSKQVKGADPLTSNGEPLVEAARKRKRSPAVNREFFDRLIRLLKILFPRLFCKELGLLGFHSLALISRTFLSIYVANLDGQIVKTIVKKDPRAFVVELTKWLLIAIPATFVNSAIRYLEGQLTLAFRTRLVTHAYMLYFSDQTYYRVSNMDGRLANPDQSLTEDVVMFAASVAHLYSNLTKPILDVVVTCYTLIKTAESKGANTTWPSVIAGIVVALTAKVLRAFSPRFGKLVAEEARRKGDLRYMHSRIIANSEEIAFYGGHKIEMLQLQRSYNSLSRQINLILFKRLWYVMLEQFLMKYLWSASGLVMVAVPIITATGYSKYDSEDVKQAALDMKEEDLVSERTQAFTTARSLLNAAADAVERIMVSYKEVTELAGYTARVYEMFEVFEDVRDGVYRRSATEVKPEETGAPQNVTHGMRVEGPLQIRGQVIDVEQGIKCENLPIITPTGDVVVSSLNMQVDEGMHLLITGPNGCGKSSLFRILSGLWPVYSGVLYKPSPDHMFYIPQRPYMSVGTLRDQVIYPHSVQEMQEKGITDRQLEEILQTVSLRYILEREGGWDAVSDWKDVLSGGEKQRMGMARMFYHKPQYALLDECTSAVSIDVEGKIFEAAKDAGISLLSITHRPSLWKYHSHLLQFDGEGGWRFEKLDASTRISLQDEKIRLETQLSGIPKMQQRLTELCRILGEDSSLPTPGDEEEDEEEDEKQTERDVQSAGKEKDLME
Protein: Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) (Q97R91)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
Interaction partners:
Sequence:
MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGVLIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSSVAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDLEGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTKAVLFDGMGLAK
Protein: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) (P62715)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62714}. Nucleus {ECO:0000250|UniProtKB:P62714}. Chromosome, centromere {ECO:0000250|UniProtKB:P62714}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P62714}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. {ECO:0000250|UniProtKB:P62714}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Immunoglobulin-binding protein 1
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
- Immunoglobulin-binding protein 1b
- Protein phosphatase methylesterase 1
Sequence:
MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
Protein: U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) (O43395)
Organism: Homo sapiens (Human)
Function: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Subcellular location: Nucleus {ECO:0000269|PubMed:17932117, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9328476, ECO:0000269|PubMed:9404889}. Nucleus speckle.
Interaction partners:
- ATP-dependent RNA helicase DHX8
- U4/U6.U5 tri-snRNP-associated protein 1
- Pre-mRNA-processing factor 6
- Small nuclear ribonucleoprotein Sm D3
- Splicing factor 3B subunit 2
- Peptidyl-prolyl cis-trans isomerase H
- U4/U6 small nuclear ribonucleoprotein Prp31
- U4/U6 small nuclear ribonucleoprotein Prp4
- U6 snRNA-associated Sm-like protein LSm3
- U5 small nuclear ribonucleoprotein 200 kDa helicase
Sequence:
MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD
Protein: tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6) (E9PDU5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MIKRVQNLLGHYLIHGFRVRPEPNGDLDLEAMVAVFGSKGLRVVKISWGQGHFWELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWEQLLEDKHFQSYCLLEAAPGPEGFGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGYEELLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVLLFPSRPGLLKDPGVGGKARAGAGAPVVGSGSSGGGNAFTGLGPVSTLPSLHGKQGVTSVTCHGGYVYTTGRDGAYYQLFVRDGQLQPVLRQKSCRGMNWLAGLRIVPDGSMVILGFHANEFVVWNPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCTRPHVILREGLHGREITCVKRVGTITLGPEYGVPSFMQPDDLEPGSEGPDLTDIVITCSEDTTVCVLALPTTTGSAHALTAVCNHISSVRAVAVWGIGTPGGPQDPQPGLTAHVVSAGGRAEMHCFSIMVTPDPSTPSRLACHVMHLSSHRLDEYWDRQRNRHRMVKVDPETRYMSLAVCELDQPGLGPLVAAACSDGAVRLFLLQDSGRILQLLAETFHHKRCVLKVHSFTHEAPNQRRRLLLCSAATDGSLAFWDLTTMLDHDSTVLEPPVDPGLPYRLGTPSLTLQAHSCGINSLHTLPTREGHHLVASGSEDGSLHVFVLAVEMLQLEEAVGEAGLVPQLRVLEEYSVPCAHAAHVTGLKILSPSIMVSASIDQRLTFWRLGHGEPTFMNSTVFHVPDVADMDCWPVSPEFGHRCALGGQGLEVYNWYD
Protein: At4g01897 (Dihydroorotate dehydrogenase) (Q8LC12)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAEEEFIYRISTEQEWEEFKKNGSSYGAEIDKSTCYYHLSKLDQVQLTLKNFFVDVKEYLYLLQVDPKKLGDGLIYEAVDEVNSFPHFYGPDKTFVPLPLDSVVKAEKLTFINGNFTCSFLT
Protein: Transcription factor TGA1 (DNA-binding protein TGA1a-like protein) (bZIP transcription factor 47) (AtbZIP47) (Q39237)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1. Could also bind to the Hex-motif (5'-TGACGTGG-3') another cis-acting element found in plant histone promoters.
Subcellular location: Nucleus.
Interaction partners:
- Regulatory protein NPR1
- Glutaredoxin-C7
- Regulatory protein NPR3
- Regulatory protein NPR4
- Basic leucine zipper 8
- LOB domain-containing protein 37
- Glutaredoxin-C13
- Protein NLP6
- Protein NLP7
- High-affinity nitrate transporter 2.2
Sequence:
MNSTSTHFVPPRRVGIYEPVHQFGMWGESFKSNISNGTMNTPNHIIIPNNQKLDNNVSEDTSHGTAGTPHMFDQEASTSRHPDKIQRRLAQNREAARKSRLRKKAYVQQLETSRLKLIQLEQELDRARQQGFYVGNGIDTNSLGFSETMNPGIAAFEMEYGHWVEEQNRQICELRTVLHGHINDIELRSLVENAMKHYFELFRMKSSAAKADVFFVMSGMWRTSAERFFLWIGGFRPSDLLKVLLPHFDVLTDQQLLDVCNLKQSCQQAEDALTQGMEKLQHTLADCVAAGQLGEGSYIPQVNSAMDRLEALVSFVNQADHLRHETLQQMYRILTTRQAARGLLALGEYFQRLRALSSSWATRHREPT
Protein: E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313) (A0A096LP02)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALAPGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCSKYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVMSRVRACYLSHVTELPLHIKREIYDSCTLPVQQT
Protein: ATP synthase alpha chain, mitochondrial (Q57TX9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- ATP synthase F1 subunit gamma protein, putative
- ATP synthase, epsilon chain, putative
- ATP synthase subunit beta
- ATPase subunit 9, putative
- ATPase subunit 9, putative
- ATPase subunit 9, putative
- Uncharacterized protein
- Cytochrome c1, heme protein, mitochondrial
- ATP synthase delta chain
- Uncharacterized protein
Sequence:
MRRFGSKFASGLASRCALACPLASAATAPAGASTTSSTSSAQKSFFKTTEMIGYVHSIDGTIATLIPAPGNPGVAYNTIIQIQVSPTTFAAGLVFNLEKDGRIGIILMDNITEVQSGQKVMATGQLLHIPVGAGVLGKVVNPLGHEVPVGLVTRSRRLLDSTLGKVDTGAPNIVSRSPVNYNLLTGFKAVDTMIPIGRGQRELIVGDRQTGKTSIAVSTIINQVRINQQILSKNAVISIYVSIGQRCSNVARIHRLLQSYGALRYTTVMAATAAEPAGLQYLAPYAGVTMGEYFMNRGRHCLCVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAAMLSPGKGGGSVTALPIVETLSNDVTAYIVTNVISITDGQIYLDTKLFTGGQRPAVNIGLSVSRVGSSAQNAAMKGVAGKLKGILAEYRKLAADSVGGQQVQTIPMIRGARFVALFNQKQPSYFMNAIVSLYACLNGYLDDVKVQYVKFYEYLLVHRDLGIMYGTAKNKFFYMYVQELNYLIRFFTLNSPILHGELEEMLKQHTHLFLQHYQSKMNAIKSEKDVKALKNLLYSCKRAV
Protein: Transcriptional regulator TAC1 (Protein TELOMERASE ACTIVATOR1) (Q9SR34)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Activation factor which mediates telomerase activity and potentiates responses to auxin through the regulation of BT2. Binds in vitro to the DNA sequence 5'-GACAGTGTTAC-3' of the BT2 promoter.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- F3L24.15 protein
- Telomerase reverse transcriptase
- BTB/POZ and TAZ domain-containing protein 2
- U-box domain-containing protein 29
- Pentatricopeptide repeat-containing protein At4g22760
- Copper transport protein family
- Cyclin-dependent protein kinase inhibitor SIM
- Signal peptide peptidase-like 4
Sequence:
MENIKNPKNADDCSDSISKNSHQGVDDSLNQSRSYVCSFCIRGFSNAQALGGHMNIHRRDRAKLRQKLMEDNKDDVVAESDASEVVSLDLNEQQQQQGEALTCDDHDQYVDNDISPKQKLEFWVQESKLDTNDHGKVTEASIDGSSSSHHRDIEVLDLELRLGQSVVKKKTT
Protein: GS homeobox 2 (Genetic-screened homeobox 2) (Homeobox protein GSH-2) (Q9BZM3)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development. During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:31412107}. Cytoplasm {ECO:0000269|PubMed:31412107}.
Interaction partners:
- Achaete-scute homolog 1
Sequence:
MSRSFYVDSLIIKDTSRPAPSLPEPHPGPDFFIPLGMPPPLVMSVSGPGCPSRKSGAFCVCPLCVTSHLHSSRGSVGAGSGGAGAGVTGAGGSGVAGAAGALPLLKGQFSSAPGDAQFCPRVNHAHHHHHPPQHHHHHHQPQQPGSAAAAAAAAAAAAAAAALGHPQHHAPVCTATTYNVADPRRFHCLTMGGSDASQVPNGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGTQRNSHAGCKCVGSQVHYARSEDEDSLSPASANDDKEISPL
Protein: Glucosamine-6-phosphate deaminase 1 (GlcN6P deaminase 1) (EC 3.5.99.6) (Glucosamine-6-phosphate isomerase 1) (Protein oscillin) (A4FV08)
Organism: Bos taurus (Bovine)
Function: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (By similarity). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O88958}.
Interaction partners:
- N-acetylglucosamine-6-phosphate deacetylase
- Glucosamine 6-phosphate N-acetyltransferase
- Glutamine--fructose-6-phosphate aminotransferase 2
- Glutamine--fructose-6-phosphate aminotransferase 1
- Glucose-6-phosphate isomerase
- Mannose-6-phosphate isomerase
- Hexokinase-2
- hexokinase
- Hexokinase-1
- Glucosamine-6-phosphate deaminase 2
Sequence:
MKLIILDHYSQASEWAAKYIRNRIIQFNPGPDKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAADLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGDLAKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKEIEKSQSSKKPYSD
Protein: Heat shock 70 kDa protein BIP1 (Heat shock 70 kDa protein 11) (Heat shock protein 70-11) (AtHsp70-11) (Luminal-binding protein 1) (AtBP1) (BiP1) (Q9LKR3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). Involved in polar nuclei fusion during female gametophyte development and is essential for the regulation of endosperm nuclei proliferation. Involved in sperm nuclear fusion with central cell polar nuclei at fertilization, which is critical for normal endosperm nuclear proliferation. Required for pollen development and pollen tube growth. Possesses ATPase activity in vitro.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:23624714}. Nucleus {ECO:0000305}.
Interaction partners:
- Heat shock 70 kDa protein 17
- Protein disulfide isomerase-like 1-1
- Endoplasmin homolog
- Serine/threonine-protein kinase/endoribonuclease IRE1b
- DnaJ protein ERDJ2A
- Protein disulfide isomerase-like 1-3
- Serine/threonine-protein kinase/endoribonuclease IRE1a
- Protein disulfide isomerase-like 1-2
- DnaJ protein ERDJ3B
- Calnexin homolog 1
Sequence:
MARSFGANSTVVLAIIFFGCLFALSSAIEEATKLGSVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVGFTDSERLIGEAAKNQAAVNPERTVFDVKRLIGRKFEDKEVQKDRKLVPYQIVNKDGKPYIQVKIKDGETKVFSPEEISAMILTKMKETAEAYLGKKIKDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKKGGEKNILVFDLGGGTFDVSVLTIDNGVFEVLSTNGDTHLGGEDFDHRVMEYFIKLIKKKHQKDISKDNKALGKLRRECERAKRALSSQHQVRVEIESLFDGVDFSEPLTRARFEELNNDLFRKTMGPVKKAMDDAGLQKSQIDEIVLVGGSTRIPKVQQLLKDFFEGKEPNKGVNPDEAVAYGAAVQGGILSGEGGDETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIQVFEGERSLTKDCRLLGKFDLNGIPPAPRGTPQIEVTFEVDANGILNVKAEDKASGKSEKITITNEKGRLSQEEIDRMVKEAEEFAEEDKKVKEKIDARNALETYVYNMKNQVNDKDKLADKLEGDEKEKIEAATKEALEWLDENQNSEKEEYDEKLKEVEAVCNPIITAVYQRSGGAPGGAGGESSTEEEDESHDEL
Protein: Kelch-like protein 41a (Kelch repeat and BTB domain-containing protein 10b) (E9QIN8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in skeletal muscle development and differentiation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O60662}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A2AUC9}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O60662}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O60662}.
Interaction partners:
- N-lysine methyltransferase SMYD2-B
- Myozenin-1a
- Trinucleotide repeat-containing 18
- Zinc finger protein 296
- Chemokine
- Bardet-Biedl syndrome 1.
- Bardet-Biedl syndrome 9.
Sequence:
MEPMSVKEDLRLFQSTLLQDGLKELLKENKFVDCILKVGDRSLPCHRLIMAACSPYFRELYFTEDGTEKKDANKEVVLENVDPNIMDMIVNYLYSADIDITDDNVQDVFAVANKFQIPSVFTVCVNYLQNKLSLGNCLAIFRMGLVLNCPRLAVSARDFIAEHFETLSKDEEFLEFNAPEFFAIIGCDALNVEKEELVFELLMKWVRKNKENRAKALGDAFEHIRFRLLPEKYLKEKVEKDDIIKADPELIKKLKVIKDAFAGKLPQIKEGEKEGEGENELPGFLNDSQRLGMFNRDLILMINDTAAVAYDANENECFLAAMAEQIPRNHVSITSKKNLLYVAGGLFVDEENKDSPLQCYFYQMDPHSPNWIALPPMPSPRCLFAMGEFENLLFAVAGKDLQSNESLDSVLCYDVDKMKWLETKKLPLRIHGHSVISQNGLVYCIGGKTDENKTINKMFAYNHKKSEWKELAAMKTPRSMFGATVHKGKIVVVGGVNEDGLLSSCEAYDFGTNKWEVFAEFAQERSSVNVLSVDGVLYAVAGFTIKENEDKQCVPSEITDIWQYEEDKKQWSGMIGEMRYASGASCVSMRLNVAKMPKL
Protein: TATA-box-binding protein (Q8I440)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Transcription initiation factor TFIID subunit 7, putative
- Zinc finger protein, putative
- General transcription factor TFIIB
- Transcription initiation factor IIE subunit alpha, putative
- B-related factor 1
- Transcription initiation factor IIA subunit 1, putative
- DNA-directed RNA polymerases I, II, and III subunit RPABC1, putative
- Transcription initiation factor IIF subunit alpha
- DNA-directed RNA polymerase II subunit RPB3, putative
- Transcription elongation factor s-II, putative
Sequence:
MHKEEKEKDKKKDNNYDNDYHNDYHNDYHNDYHNDYDNENDCNNNEREGSVHGDNIHAYEEQNYENDILNIINKQMDNIKSNDPIKNNSNNSYNNNFLDMNFLEQDQLFLENINQDNVVSAHYTSEYDNNEKEKSDDLKNKLVHKNISLNIHNIISSANLCIDINLRLVAVSIRNAEYNPSKINTLIIRLNKPQCTALIFKNGRIMLTGTRTKKDSIMGCKKIAKIIKIVTKDKVKFCNFKIENIIASANCNIPIRLEVLAHDHKEYCNYEPELFAGLVYRYKPTSNLKSVILIFVSGKIIITGCKSVNKLYTVFQDIYNVLIQYKN
Protein: Hydroxyproline O-galactosyltransferase GALT6 (EC 2.4.1.-) (Beta-1,3-galactosyltransferase 19) (Q9LV16)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. Utilizes UDP-galactose solely as sugar donor. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:26690932}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Beta-1,6-galactosyltransferase GALT31A
- Hydroxyproline O-galactosyltransferase HPGT3
- Hydroxyproline O-galactosyltransferase HPGT2
- Beta-1,6-galactosyltransferase GALT29A
- Beta-glucuronosyltransferase GlcAT14A
- Beta-arabinofuranosyltransferase RAY1
- Beta-glucuronosyltransferase GlcAT14C
- Fucosyltransferase 6
- Beta-glucuronosyltransferase GlcAT14B
- Probable fucosyltransferase 4
Sequence:
MRKPKLSKLERLEKFDIFVSLSKQRSVQILMAVGLLYMLLITFEIPFVFKTGLSSLSQDPLTRPEKHNSQRELQERRAPTRPLKSLLYQESQSESPAQGLRRRTRILSSLRFDPETFNPSSKDGSVELHKSAKVAWEVGRKIWEELESGKTLKALEKEKKKKIEEHGTNSCSLSVSLTGSDLLKRGNIMELPCGLTLGSHITVVGKPRAAHSEKDPKISMLKEGDEAVKVSQFKLELQGLKAVEGEEPPRILHLNPRLKGDWSGKPVIEQNTCYRMQWGSAQRCEGWRSRDDEETVDGQVKCEKWARDDSITSKEEESSKAASWWLSRLIGRSKKVTVEWPFPFTVDKLFVLTLSAGLEGYHVSVDGKHVTSFPYRTGFTLEDATGLTINGDIDVHSVFAGSLPTSHPSFSPQRHLELSSNWQAPSLPDEQVDMFIGILSAGNHFAERMAVRRSWMQHKLVKSSKVVARFFVALHSRKEVNVELKKEAEFFGDIVIVPYMDSYDLVVLKTVAICEYGAHQLAAKFIMKCDDDTFVQVDAVLSEAKKTPTDRSLYIGNINYYHKPLRQGKWSVTYEEWPEEDYPPYANGPGYILSNDISRFIVKEFEKHKLRMFKMEDVSVGMWVEQFNNGTKPVDYIHSLRFCQFGCIENYLTAHYQSPRQMICLWDKLVLTGKPQCCNMR
Protein: RNA-binding protein with multiple splicing (RBP-MS) (RBPMS) (Heart and RRM expressed sequence) (Hermes) (Q93062)
Organism: Homo sapiens (Human)
Function: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:17099224, ECO:0000269|PubMed:24860013}. Cytoplasm {ECO:0000269|PubMed:17099224, ECO:0000269|PubMed:24860013}. Cytoplasm, Stress granule {ECO:0000269|PubMed:24860013}. Cytoplasm, P-body {ECO:0000269|PubMed:26347403}. Note=Localized to cytoplasmic stress granules after oxidative stress (PubMed:24860013). Translocates into cytoplasmic stress granules that probably corresponds to P-bodies in response to oxidative stress (PubMed:26347403). {ECO:0000269|PubMed:24860013, ECO:0000269|PubMed:26347403}.
Interaction partners:
- KH domain-containing RNA-binding protein QKI
- RNA binding protein fox-1 homolog 2
- RNA-binding protein with multiple splicing 2
- Ataxin-1
- RNA binding protein fox-1 homolog 1
- Dynactin subunit 6
- Atrophin-1
- Epithelial splicing regulatory protein 1
- POU domain, class 4, transcription factor 1
Sequence:
MNNGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKANTKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAFTYPASLHAQMRWLPPSEATSQGWKSRQFC