wanglab/gogpt-training-data huggingface dataset:
Protein: Glutathione peroxidase-like peroxiredoxin HYR1 (EC 1.11.1.24) (Glutathione peroxidase homolog 3) (GPx 3) (Hydrogen peroxide resistance protein 1) (Oxidant receptor peroxidase 1) (Phospholipid hydroperoxide glutathione peroxidase 3) (PHGPx3) (P40581)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYR1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYR1/GPX3 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598'), which causes its nuclear accumulation and activation, and a reduced Cys-36 in HYR1/GPX3.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}. Peroxisome matrix {ECO:0000269|PubMed:22659048}.
Interaction partners:
- Peroxiredoxin TSA1
- YAP1-binding protein 1
- AP-1-like transcription factor YAP1
- Peroxiredoxin PRX1, mitochondrial
- Peroxiredoxin AHP1
- Glutathione reductase
- Thioredoxin-2
- Thioredoxin-1
- Superoxide dismutase
- Glutaredoxin-2
Sequence:
MSEFYKLAPVDKKGQPFPFDQLKGKVVLIVNVASKCGFTPQYKELEALYKRYKDEGFTIIGFPCNQFGHQEPGSDEEIAQFCQLNYGVTFPIMKKIDVNGGNEDPVYKFLKSQKSGMLGLRGIKWNFEKFLVDKKGKVYERYSSLTKPSSLSETIEELLKEVE
Protein: Hexosyltransferase (EC 2.4.1.-) (Q38G28)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}.
Interaction partners:
Sequence:
MYFCLYTACLVRVTLFHLKLLKMSIRFVSQDVRRIWEIEDYLVVAGIPSIDNDERFRRKNLQRQTCWSYPEVARKSNNFTGKLLIIYALSAHTNNNCELKEIVEEEAELNQDVIILPVCDVNPTTSKKVGEAGNWGWEPEITMSRKTYLWFKFAVEIFKPTNPYIMKADDDIFMRVPLYLKYLYGLPREKLNVARAVGELDESIAKLTWYVVGYANTISRGVVKEIVGFSQISKLLTSRISFRNFDKYIEYAALNEDIMVGEVIRHKMKLEGLLTVGMQDCHYVMHVKRPLDRFVKENPKLIVFHHIAEEEYKWLMTNPQTTIERNAEPLLRTQQIVPFWHEASC
Protein: Guanine nucleotide exchange factor subunit ric1 (Protein ric1) (O42656)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Protein sat1
- GTP-binding protein ryh1
- Serine/threonine-protein kinase hal4
- Protein MON2 homolog
- GTPase-activating protein gyp10
- AP-1 complex subunit sigma-1
- Uncharacterized protein C1778.05c
- Uncharacterized protein C29A10.17
- Uncharacterized protein tam1
- Uncharacterized protein C23D3.16
Sequence:
MYFLHGTPQRIQLSSRAIQICRIPKVSFFVVLTETEILIYQIRPLTLISKITKSQNLFERHGKNKKIAVNSEYGIIAVATEKNYVAVYHFTLNASKPVLTPSPYLTRYDDGPGEIFGPIKCEIQYKLAMRYGGGLKCLEIQRDSIVYAADSAPIIQVSTLETTDPNKLWKVSSKQYDLREVTWFLDHSSLISRLYFDVKIDTFFWMSTDGRVYANIGVSSNTNTKSLFGLCVHNPVDLNKSDNDKDINEDLESKLREKKATVLSTNARFSLLYVGTADGTVYAYEIRDFGRQYVQTHSFKYSASSGKVNHIATTGDGHQVMVGYDDGWATLSPYLNLCCASSETEYFNFGLSCGFWDRDSSSFYGLGSKNFSSTGEAEGTGLSTPIIAESLKENDEFFAMEKENVDIQYLSQNDNTNDVLYSITDSKQFISTIYILPFLKSTIVSSVQSTLQVCGAQTSDRLYISKSYEFCSSVKNNFGIDFWDQVEYPQPYVASEWPIRYVSIKDDGSLIAIAGLHGLAIYVCSKKTWFLYKDANMEQLISVTCPMIWCSQFLLAGVVCESNFELHLYKAKGPLDDRENLAKLSFTSTIVTMSVCDEYSLVVYTADNFLHHIRFDINELGRLELDYLTSVNFAPIFTTPSRVRSITLLLPKDLANIQPSDLLFYAVLLVLINGKLVLLSLKKQHSKELLYQCSMLAGDVEFYFINGSQEIPSLFHSIWIMTGKGLKLWLSFSEILSSVLINTKNLIDGLPKFLNTSKRVSLENFHRLSVEDLRSPSFVYKNGVDCNFDNTHLAKLIKNVNISEKFQKECIDLESQGCLLTVLSNYGLLLTAYTQGHKNLVNKMEYAHIQIGVYPFLPEIVRALLLLDKREQAIDLVKTYGHLHYINFVLEKLLSSSLLTYNSSQRDKLLYEVSLLFKDLQEFTTFKIVLGCLRKTEAEYWPMIFKYFGEPKDLMKKCLETEDVKSAAECLIIWQIHQGSASCASTFLSIYEMALKIKNWDVCTELSSYLVSLDPEKRLLKTALELLDEGPDSKDIRLYDQFNNLMKEVDKY
Protein: Myosin light chain 1 (Calmodulin-like myosin light chain MLC1) (Myosin-2 light chain) (P53141)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential light chain for the class II conventional myosin MYO1. Acts also as light chain for the class V unconventional myosin MYO2 and for IQG1. Involved in the assembly of the contractile actomyosin ring at the bud neck during cytokinesis by recruiting IQG1 to the bud neck. Also required for chitin and MYO2-dependent secretory vesicle deposition to the center of the bud neck for septum formation. May stabilize MYO2 by binding to its IQ domains. Its major function is probably not to regulate MYO1 activity, but rather to coordinate actin ring formation and targeted membrane deposition during cytokinesis via its interactions with MYO1, IQG1 and MYO2.
Subcellular location: Bud neck {ECO:0000269|PubMed:10873803, ECO:0000269|PubMed:11082046}. Bud tip {ECO:0000269|PubMed:10873803, ECO:0000269|PubMed:11082046}. Note=Concentrates to sites of polarized growth, namely to the incipient bud site in G1, to the bud tip during S and G2 phases of the cell cycle and to the bud neck during cytokinesis. {ECO:0000269|PubMed:11082046}.
Interaction partners:
- Myosin-2
- Ras GTPase-activating-like protein IQG1
- Myosin-1
- Myosin light chain 2
- Myosin-4
- Cytokinesis protein 2
- Tubulin beta chain
- Calcium-channel protein CCH1
- SWI5-dependent HO expression protein 3
- Actin
Sequence:
MSATRANKDIFTLFDKKGQGAIAKDSLGDYLRAIGYNPTNQLVQDIINADSSLRDASSLTLDQITGLIEVNEKELDATTKAKTEDFVKAFQVFDKESTGKVSVGDLRYMLTGLGEKLTDAEVDELLKGVEVDSNGEIDYKKFIEDVLRQ
Protein: Nectin cell adhesion molecule 1 (F1LNP8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}. Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Nectin-3
- Partitioning defective 3 homolog
- Afadin
- Cell adhesion molecule 3
- Nectin cell adhesion molecule 2
- Nectin-4
- Cadherin-1
Sequence:
MARMGLAGAAGRWWGLALGLTAFFLPGTHTQVVQVNDSMYGFIGTDVILHCSFANPLPTVKITQVTWQKASNGSKQNMAIYNPTMGVSVLPPYEKRVEFLRPSFIDGTIRLSHLELEDEGMYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRARKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHRQSLACIVNYHLDRFRESLTLNVQYEPEVTIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFRGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPTPEHGRRAGQMPTAIIGGVAGSVLLVLIVVGGIIVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
Protein: Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (A1XQU3)
Organism: Sus scrofa (Pig)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P50914}.
Interaction partners:
- Large ribosomal subunit protein eL6
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL27
- 40S ribosomal protein S30
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein eL36
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein uL18
Sequence:
MVFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDFILKFPHSARQKYVRKAWEKADINAKWAATRWAKKIEAREKKAKMTDFDRYKVMKARKMRNRLIKLEVKKLQKAALLKASPKKALAKGAAAAAAAAAAKVPVKKITTAGKKAPAQKAPAQKAAGQKAAPPPKAQKVQKPPAQKAPAPKASGEKA
Protein: Ribonuclease H2 subunit B (RNase H2 subunit B) (Rnh2B) (RNase H(202)) (Ribonuclease HI subunit B) (Q05635)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ribonuclease H2 subunit C
- Ribonuclease H2 subunit A
- ATP-dependent helicase SGS1
- Proliferating cell nuclear antigen
- Flap endonuclease 1
- DNA topoisomerase 1
- Ribonuclease H
- DNA polymerase epsilon catalytic subunit A
- DNA repair and recombination protein RAD52
- Crossover junction endonuclease MMS4
Sequence:
MTVSNIGGEERLIILPDDYETSKTINTFTLPPPSNITSKPRIELFENINGKLYEIRSFQFGKGPSYSHEEDLANDKYHYTKENHPIKSTFIVNTSDPTDGYVFNSSKIHFCSLYDIAFSLIGFYYRNSVSADEQDYSNSSDTGENQKSNSKTNEKFLTVRDYHDFLTDNHDKNWENISLSRLKSGLAKVSETIEEAGDVYYKITSAMITQFLLGKVSKIVENFPPSIPTLKNAPTEIKQCYKVVMATNLLVSLIPRAAYHNLLTFSPTMDSGCLNPDIKASFIELENYETTNELQNAERELLMKSAMNVGLNSNGRVSLPVKKVTKKIVQNKKPKVAIGKGAIDGFFKRK
Protein: TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3) (Q8C0G2)
Organism: Mus musculus (Mouse)
Function: Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development. Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF. Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism. Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts. In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production. However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9Y228}. Golgi apparatus membrane {ECO:0000269|PubMed:26195727}; Single-pass type IV membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:30115741}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9Y228}. Note=Accumulates on the mitochondria after virus infection. {ECO:0000250|UniProtKB:Q9Y228}.
Interaction partners:
- FGFR1 oncogene partner 2 homolog
- Striatin-3
- Serine/threonine-protein kinase 24
- Striatin-interacting protein 1
- Striatin
- Striatin-4
- Striatin-interacting proteins 2
- Serine/threonine-protein kinase 26
- Serine/threonine-protein kinase 25
- Suppressor of IKBKE 1
Sequence:
MISSDSRSSPGLARWAESYEAKCERRQETRENRRRRRNETTCRQPGKVLRTQHKERLQGARQLQFLKRRNLEEEKKGQAREQGPSSKTDGGTGQVSILKESLPGANKASFPGQQETGISSEVFPALHHSSSGIQRDLGGHHASHGRAFPPQDSDIKKPHRQHRGTQTKAEEALPTIKNDASQQTNCGVAVLDKDIIQLSEYLKEALHRELILKKKMVILQDLLPALIRASDSSWKGQLNEDKLKGKLRSLENQLYTCLQKHSPWGMKKVLLEMEDQRSSYEQKAKASLQKVLEEKMCAEQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQTKLESLQGDGEQQSSETQDLQDQLKKSEEEKQALVSKVQQLQSLLQNQSLQLQEQEKLLKKDQGLPVWNPKLSLDEVKPEGTRKEKEEELRDQLQKETFQLQVKENELQCGQWLPVLMVVIATALAVFLANKGNLVI
Protein: PPFIA binding protein 2 (A0A0G2K383)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Liprin-alpha-3
- PTPRF interacting protein alpha 2
- Liprin-alpha-4
- PTPRF interacting protein alpha 1
Sequence:
MTSDASHMLEAALEQMDGIIAGTKTAADFSDGTCEPGLSPPSSCLNSMPVLHLIEDLRLALEMLALPQEREALLSQIPGPTAAYIKEWFEDSLSQVNHHSAASNETYQERLARLEGDKESLILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQKEQEEKQRKAESVLNVISELQEQMCRLQLDIHRQIQERLLLARDHPEEVVAGDHEAKPQPCSRDCAPWEGSPELLQELKHLKIKVEELENERNQYEWELKATKAEVAQLQEQVALKDAEIERLHSQLSRSSALHSDHAERDQEIHRLKMGMETLRVANEDKDRRIEELTGLLNQYLRVKEIVMATQGSSERTLSINEDEIEGSFRKWNTTSKSPEEVMKQEVSPRCSSPTPGPPPLPQKSLETRAQKKLSCSLEDLRCESGNKCINGNQTSPVGEPKDSSFLAEQKYPTLPGKLSGATPNGEAAKSPPTASLQPDSSGSSQPKLRDTEGGWEDIVMTNELSSTSSGTESSPQSPLTPDGKRSPKGIKKFWGKIRRTQSGNFNTDTPGMVEFRRGGLRATAGPRLSRTRDTKGQKCDANAPFAQWSTERVCTWLQDFGLAQYVIFARQWVASGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHVWVTRWLDDIGLPQYKDQFYESRVDGRMLQYLTVNDLLFLKVTSQLHHLSIKCAIHVLHVNKFNPNCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKRDKMASPAYTPLTTTAKVRPRKLGFSHFGNMRKKKFDESTDYICPMEPGDAVSDSHRVYGVYRGLSPLDNHELDGLDQMAPSEGTVTQIGLLSQDIHRLTTLLSQDQLLNDPPGCP
Protein: Uncharacterized protein (Q384N3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVVSMQRSSAKKSSQGNTGVSSPPRKRISFMQNRNTVRLVKPPPRCLNSEYWFTETMSIVKKGDAFEIRQGNIFTLEVEKRMQLTSVASRSPTTSSSSSHDGSDGRVSLQIMAADLFGLRSPSNKWLSIASVREGEVEKVRVILPEGIYMLRCVGRRPVQVFVLNWCLIRRLG
Protein: O-fucosyltransferase 20 (O-FucT-20) (EC 2.4.1.-) (O-fucosyltransferase family protein) (O64884)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in the biosynthesis of matrix polysaccharides and contribute to the biomechanics and development of the plant cell wall.
Subcellular location: Golgi apparatus membrane {ECO:0000269|Ref.11}; Single-pass type II membrane protein {ECO:0000305|Ref.11}.
Interaction partners:
- At1g25400
- F21O3.6 protein)
- Poly polymerase
- Nematode resistance protein-like HSPRO2
- Expressed protein)
- Calmodulin-binding receptor-like cytoplasmic kinase 1
- Ethylene-responsive transcription factor ERF012
- BTB/POZ and TAZ domain-containing protein 5
- Cytochrome P450, family 76, subfamily C, polypeptide 6
- Calmodulin-binding receptor-like cytoplasmic kinase 2
Sequence:
MALSKNSNSNSFNKKKVSYISVPSQIINSLSSSSLQSLLVSPKKSSRSTNRFSFSYRNPRIWFFTLFLVSLFGMLKLGFNVDPISLPFSRYPCSTTQQPLSFDGEQNAASHLGLAQEPILSTGSSNSNAIIQLNGGKNETLLTEGDFWKQPDGLGFKPCLGFTSQYRKDSNSILKNRWKYLLVVVSGGMNQQRNQIVDAVVIARILGASLVVPVLQVNVIWGDESEFADIFDLEHFKDVLADDVHIVSSLPSTHVMTRPVEEKRTPLHASPQWIRAHYLKRINRERVLLLRGLDSRLSKDLPSDLQKLRCKVAFQALRFSPRILELGNKLASRMRNQGQYLSLHLRMEKDVWVRTGCLPGLTPEYDEIVNSERERHPELLTGRSNMTYHERKLAGLCPLTALEVTRLLKALEAPKDARIYWAGGEPLGGKEVLEPLTKEFPQFYNKHDLALPGELEPFANKASVMAAIDYIVCEKSDVFIPSHGGNMGHALQGQRAYAGHKKYITPNKRQMLPYFMNSSLPESDFNRIVKDLHRESLGQPELRMSKAGKDVTKHPVPECMCSDRQQQEQQSDA
Protein: Microtubule-associated protein (Q95QG4)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU000686}.
Interaction partners:
- Cyclin-dependent-like kinase 5
- Methionine aminopeptidase 2
- Echinoderm microtubule-associated protein-like elp-1
- Tubulin beta-1 chain
- Presenilin sel-12
- E3 ubiquitin-protein ligase CHIP
- Protein kinase domain-containing protein
- Patronin
- SUPpressor
- Amyloid-beta-like protein
Sequence:
MSTPQSEPGSEPGSPGENENSMETQYSQGSFPEVAVEPEPEPEPEPEPEPEPEPEPEPEPEPKPKPEVEPVPQPEPEPEYQPEPEPEPEVEPEPEPEPVPEPEPEPEPEPEPVVEKEEEVVVESPPREQEPEKSGKSKPSSPIPDAPTMEDIAPRELESLNFSETSGTSDQQADRIMQNNENERVEEKKQMSPTPSQPQHKTPQRSGIRPPTAILRQPKPIPASLPRPATATPSSQRAISTPRQTASTAPSPRPISKMSRERSDVQKSTSTRSIDNVGRMTPKVNAKFVNVKSKVGSVTNHKAGGGNVEIFSEKRLYNAQSKVGSLKNATHVAGGGNVQIENRKLDFSAASPKVGSKTNYQPAKSDVKIVSEKLTWQAKSKVGSMDNAAHKPAGGNVQVISSEVAVSRPKMMTATIIDKKKDFAKRQSVSQRSSSNSLLPNKFPGAIYPLSPDFIFNR
Protein: Signiferin-1 (P86130)
Organism: Crinia signifera (Common eastern froglet)
Function: Induces mouse splenocyte proliferation and guinea pig smooth muscle contraction through binding to CCK-BR.
Subcellular location: Secreted {ECO:0000269|PubMed:15317042}.
Interaction partners:
Sequence:
RLCIPYIIPC
Protein: Homeobox protein HAT3.1 (Q04996)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds only to large DNA fragments. Recognizes a DNA fragment carrying 8 copies of box7 motif of the light-induced cab-E promoter of Nicotiana plumbaginifolia. Also recognizes the box7m1 motif.
Subcellular location: Nucleus.
Interaction partners:
- Protein MRG1
- Protein MRG2
- Lysine-specific demethylase ELF6
- Cysteine proteinase inhibitor 4
- PHD finger protein ING2
- Cysteine proteinase inhibitor 3
- At2g13960
- Protein kinase superfamily protein
- F28K20.8 protein
- PHD finger protein
Sequence:
MYKAVSKRVTRSSGSGLKQTNVDNGGEISPTVDRVSEQGKSSEAGSHMPTDANGNGHLHHEIMDHGKGNEEQKPTPQTVKKDSNTNTKFSGSHRELVIGLPCRGQFEIHNRSRASTSSKRLGGGGERNVLFASHKRAQRSKEDAGPSSVVANSTPVGRPKKKNKTMNKGQVREDDEYTRIKKKLRYFLNRINYEQSLIDAYSLEGWKGSSLEKIRPEKELERATKEILRRKLKIRDLFQHLDTLCAEGSLPESLFDTDGEISSEDIFCAKCGSKDLSVDNDIILCDGFCDRGFHQYCLEPPLRKEDIPPDDEGWLCPGCDCKDDSLDLLNDSLGTKFSVSDSWEKIFPEAAAALVGGGQNLDCDLPSDDSDDEEYDPDCLNDNENDEDGSDDNEESENEDGSSDETEFTSASDEMIESFKEGKDIMKDVMALPSDDSEDDDYDPDAPTCDDDKESSNSDCTSDTEDLETSFKGDETNQQAEDTPLEDPGRQTSQLQGDAILESDVGLDDGPAGVSRRRNVERLDYKKLYDEEYDNVPTSSSDDDDWDKTARMGKEDSESEDEGDTVPLKQSSNAEDHTSKKLIRKSKRADKKDTLEMPQEGPGENGGSGEIEKSSSSACKQTDPKTQRLYISFQENQYPDKATKESLAKELQMTVKQVNNWFKHRRWSINSKPLVSEENVEKLKTGKEGECETSVAGSSKQTMETESVAEKPTNTGSRKRRRK
Protein: Apoptosis regulator Bcl-2 (P10415)
Organism: Homo sapiens (Human)
Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P10417}.
Interaction partners:
- Bcl-2-interacting killer
- Beclin-1
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
- Bcl-2-like protein 1
- NACHT, LRR and PYD domains-containing protein 1
- Beclin-2
- Cellular tumor antigen p53
- Phorbol-12-myristate-13-acetate-induced protein 1
- Nuclear receptor subfamily 4immunitygroup A member 1
- Bcl-2-like protein 11
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Protein: UDP-N-acetylglucosamine transporter UGNT1 (UDP-GlcNAc transporter 1) (Nucleotide-sugar uncharacterized transporter 3) (A8MRY9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc) across the Golgi apparatus membrane. Delivers an essential substrate for the maturation of N-glycans and the GlcNAc-containing glycosyl inositol phosphorylceramide (GIPC) class of sphingolipids in the Golgi apparatus.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:30224661}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Solute carrier family 35 protein
- Arginine-glutamic acid dipeptide repeat protein
- Glucosamine inositolphosphorylceramide transferase 1
- 3-dehydrosphinganine reductase TSC10B
- 3-dehydrosphinganine reductase TSC10A
Sequence:
MRNNPVLPVSDPPLAGENDSDGKGVDDRLFKGSAMTKRGAYAALSYMACAVMLVLFNKAALSSYDFPCVNVITLFQMVSSSLFLYALRRRKIISFTAADSFSIDSASTFVPVKTLFHTLPLAIAYLLYMLASMASVRGVNVPMYTTLRRTTVAFTMVIEYMLTGQRYTRSIIGSVGIILLGAFFAGARDLSFDFYGYGVVFLANISTAVYLATIARTGKSSGLNSFGLMWSNGIICGPILMIWTFICGDLEKTINFPHLLTPGFMVVLLCSCVLAFVLNYCIFLNTTLNSALTQTICGNMKDLFTVGLGWMLFGGLPFDLMNVIGQLFGFFGSGLYAYYKIIGR
Protein: Probable histone chaperone asf-1 (Anti-silencing function protein 1) (Q19326)
Organism: Caenorhabditis elegans
Function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Protein HIRA
- Serine/threonine-protein kinase tousled-like 1
- Protein NASP homolog 1
- WD_REPEATS_REGION domain-containing protein
- Pry-1 Interacting and CABIN1 Domain containing
- Tetratricopeptide SHNi-TPR domain-containing protein
- DNA replication licensing factor MCM2
- Histone acetyltransferase type B catalytic subunit
- Chromatin assembly factor 1 subunit A dimerization domain-containing protein
- Small nuclear ribonucleoprotein associated homolog 13
Sequence:
MASRVNIVQVQILDNPAMFVDKFKLEITFEVFEHLPHDLEWELVYVGSGTSRDFDQVLDSALVGPIPEGRHKFVFDADHPDISKIPVDDIVGVSVLLLRCKYNDQEFINMGWFVANEYTEEELKENPPSQPLIEKLSRKVETEDLRITTFPIRWTDEDPVAEPVEDEANRVFAEDDLMPLNDDGQEDDDEEEEDDDEMEANAEEVDLNESFNERLANALDGAEQKGADEKMEDDGANEDVDMADDEPGVQINTDTKVPESMAEPLSDKTNNEMVQ
Protein: Synaptosomal-associated protein 29 (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) (C9JAF7)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium membrane {ECO:0000256|ARBA:ARBA00037808}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037808}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000256|ARBA:ARBA00037854}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037854}.
Interaction partners:
Sequence:
MVDKMDQDLKISQKHINSIKSVFGGLVNYFKSKPVETPPEQNGTLTSQPNNRLKEAISTSKEQEAKYQASHPNLRKLDDTDPVPRGAGSAMSTDAYPKNPHLRAYHQKIDSNLDELSMGLGRLKDIALGMQTEIEEQDDILDRLTTKVDKLDVNIKSTER
Protein: Choline/ethanolaminephosphotransferase 1 (ETHPT) (Ethanolaminephosphotransferase 1) (EC 2.7.8.1) (EC 2.7.8.2) (Aminoalcohol phosphotransferase EPT1) (P22140)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the final step in the CDP-ethanolamine route leading to phosphatidylethanolamine (PE). Can also catalyze the formation of phosphatidylcholine (PC) from CDP-choline, but does not substantially contribute to PC biosynthesis. Preferentially uses CDP-dimethylethanolamine and CDP-propanolamine as aminoalcohol substrates. Shows highest activity toward di-unsaturated diacylglycerol species as lipid substrates. The CDP-ethanolamine pathway may play a role in maintaining the proper PE species distribution.
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein.
Interaction partners:
- Cholinephosphotransferase 1
- Ethanolamine-phosphate cytidylyltransferase
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Phosphatidylserine decarboxylase proenzyme 2
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- Lysophospholipid acyltransferase
- Phosphatidylethanolamine N-methyltransferase
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Phospholipase D1
- CTP-dependent diacylglycerol kinase 1
Sequence:
MGYFVPDSHIENLKSYKYQSEDRSLVSKYFLKPFWQRFCHIFPTWMAPNIITLSGFAFIVINVLTVFYYDPNLNTDTPRWTYFSYALGVFLYQTFDGCDGVHARRINQSGPLGELFDHSIDAINSTLSIFIFASETGMGFSYNLMLSQFAMLTNFYLSTWEEYHTHTLYLSEFSGPVEGILIVCVSLILTGIYGKQVIWHTYLFTITVGDKVIDVDTLDIVFSLAVFGLVMNALSAKRNVDKYYRNSTSSANNITQIEQDSAIKGLLPFFAYYASIALLVWMQPSFITLSFILSVGFTGAFTVGRIIVCHLTKQSFPMFNAPMLIPLCQIVLYKICLSLWGIESNKIVFALSWLGFGLSLGVHIMFMNDIIHEFTEYLDVYALSIKRSKLT