Protein: Potassium voltage-gated channel subfamily B member 2 (CDRK) (Voltage-gated potassium channel subunit Kv2.2) (Q63099)
Organism: Rattus norvegicus (Rat)
Function: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10719893, ECO:0000269|PubMed:1550672, ECO:0000269|PubMed:20202934, ECO:0000269|PubMed:9305895}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:10719893, ECO:0000269|PubMed:20202934}. Cell projection, dendrite {ECO:0000269|PubMed:10719893, ECO:0000269|PubMed:20202934}. Note=Localized uniformly throughout cell bodies and dendrites (PubMed:10719893). Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons (PubMed:20202934). {ECO:0000269|PubMed:10719893, ECO:0000269|PubMed:20202934}.
Interaction partners:
- Voltage-gated potassium channel subunit beta-2
- Voltage-gated potassium channel subunit beta-1
- Vesicle-associated membrane protein-associated protein A
- Vesicle-associated membrane protein-associated protein B
- Voltage-gated potassium channel subunit beta-3
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Ubiquitin-like protein FUBI
Sequence:
MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMRDGEGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANIKDSVDDNHLSPSRWKWARKALSETSSNKSYENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQTHSHPNPDCQEQPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGMDEHQRVRAPPFLTLSRDKGPAAREAALDYAPIDITVNLDAGASHGPLQPDSASDSPKSSLKGSNPLKSRSLKVNFQENRGSAPQTPPSTARPLPVTTADFPLTTPQHMSTILLEESPPPGTETLPGADVSAHCQGPSKGLSPRVPKQKLFPFSSRERRSFTEIDTGEDEDFLDLQRPRPDKQADPSPNCLADKPGEARDPLREEGCVGSSSPQNTDHNCRQDIYQAVGEVKKDSSQEGYKMENHLFAPEIHSNPGDTGYCPTRETSM