wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein 1 (Zinc finger homeodomain protein 1) (P28166)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Myocyte-specific enhancer factor 2
- Protein phosphatase eya
- Fasciclin-3
- Zinc finger protein chinmo
- C-terminal-binding protein
- Segmentation protein even-skipped
- Muscle-specific homeobox protein tinman
- Homeobox protein abdominal-A
Sequence:
MLSCLAPSSSRFGQEDTIIQQSMPSTSPFAMQFPSLASTLLHHNQSPKHSNPGSSGIQDAHPNQPGAAADAFLVKCTQCHKRFPEYQSLSEHIASEHPHDKLNCGAAQPESDAEDEQSNMSGSSRRYAKSPLASNNNSSTANANNNSTSSQSMNNNSELAKNHNSANKMSPMCSPGSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAASLAMQSARTASSPSQQQQQQLQQQQQLQQQQQHQMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTASFASREQLEQHEQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGSASSASRRSPSDHGKGKLPEQPSLPGLPHPMSYFASDAQVQGGSAAPAPFPPFHPNYMNAALLAFPHNFMAAAAGLDPRVHPYSIQRLLQLSAAGQQQREEEREEQQKQQQHDEEETPDEPKLVMDIEEPETKEMAPTPEATEAATPIKREESREASPDPESYRSSSQAIKQEQEPLNVAEERQTPVEEHAPVEHAADLRCSRCSKQFNHPTELVQHEKVLCGLIKEELEQHFQQQQATSFALASASEEDEEDEEMDVEEEPRQESGERKVRVRTAINEEQQQQLKQHYSLNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQNNQAAGAAPPMPIDSQASLTREDQPLDLSVKRDPLTPKSESSPPYIAPPSGEALNPEAINLSRKFSTSASMSPASISPSSAAALYFGAAPPPSPPNSQLDSTPRSGQAFPGLPPYMLPMSLPMEALFKMRPGGDFASNHALMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDEFGAGVLMPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE
Protein: Calcium-binding EF-hand domain-containing protein (Q1ZXH5)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 1
- NADH dehydrogenase iron-sulfur protein 7
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase subunit 9
- NADH-ubiquinone oxidoreductase 49 kDa subunit
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
Sequence:
MNFFKKLCRILNEIIRTDSDFNQSITLQELIADLKNKKAKNPVGTAVAVFRDADKNKNGKLTYEEIRNWAITKNSNAINDALTKEVNEILSPMDKDNDGNLTAGEMLDYFVKQGLKLNDACEMIKSYFEQVDKDSDGILTVCELKKFIGADLQVPSQ
Protein: Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) (P50395)
Organism: Homo sapiens (Human)
Function: GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A.
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19570034}.
Interaction partners:
- Ras-related protein Rab-1A
- Ras-related protein Rab-1B
- Ras-related protein Rab-8A
- Ras-related protein Rab-5A
- Ras-related protein Rab-10
- Ras-related protein Rab-5C
- Ras-related protein Rab-6A
- Rab GDP dissociation inhibitor alpha
- Ras-related protein Rab-3A
- Ras-related protein Rab-7a
Sequence:
MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPGSPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKNIYKRMTGSEFDFEEMKRKKNDIYGED
Protein: Perilipin (Q2TCH2)
Organism: Sus scrofa (Pig)
Subcellular location: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
Interaction partners:
Sequence:
MAINKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGIQSAGSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPVTSTADKVLGAALAGCELAWGMAKDTAEYAANTRAGRLASGGADLALGGVEKVVEPLLPPAKEESASAPGHQHGQKPPKAKPSLVSRVGTLASTISQHTFQATSRALKQGHALAMWIPGVAPLSSLAQWGASAAMQVVSRRQSVVRVPWLHNLAATQEEDHDDQTDTEGEEMEEEAEPETEENKLSEGAALPGPQGFLGKAVHTLQRALQSTISLVTWAPATALGTAGRMLPFTPARAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPPEAERRETERRGSGALPAAPEAAPRPAPTRGSLRSARGPGAEDRGDTAAALRPAFPAVPREKPARRVSDSFFRPSVMEPILGRAQYNQLRKKS
Protein: Solute carrier family 41 member (D6RF72)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU369007}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU369007}.
Interaction partners:
Sequence:
MDGTETRQRRLDSCGKPGELGLPHPLSTGGLPVASEDGALRAPESQSVTPKPLETEPSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQHWPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQIDDPQE
Protein: Conserved protein (O53287)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable enoyl-CoA hydratase EchA17
- Probable conserved ATP-binding protein ABC transporter
- Conserved protein
- Phosphoserine phosphatase SerB2
- Probable methanol dehydrogenase transcriptional regulatory protein MoxR2
- Probable cytochrome c oxidase subunit 1
Sequence:
MNSPREPLVPPPTPRPAATVMLVRDPDAGSASGLAVFLMRRHAAMDFAAGVMVFPGGGVDDRDRDADLGRLGAWAGPPPQWWAQRFGIEPDLAEALVCAAARETFEESGVLFAGPVDQDHSAPNSIVSDASVYGDARRALADRTLSFADFLQREKLVLRSDLLRPWANWVTPEAELTRRYDTYFFVGALPEGQRADGENTESDRAGWVLPADAIADFAAGRNFLLPPTWTQLDSLAGHTVADVLAVERQIVPVQPQLARNGDNWEIEFFDSDRYNQARRSGGSTGWPL
Protein: L-Rhamnulokinase (RhaB) (RhuK) (EC 2.7.1.5) (ATP:L-rhamnulose phosphotransferase) (L-rhamnulose 1-kinase) (Rhamnulose kinase) (P32171)
Organism: Escherichia coli (strain K12)
Function: Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). It could also play a role in the metabolism of some rare sugars such as L-fructose. Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. Uridine triphosphate (UTP), cytidine 5-triphosphate (CTP), guanosine 5-triphosphate (GTP), and thymidine triphosphate (TTP) also can act as phosphoryl donors. It can also phosphorylate L-fuculose and L-xylulose.
Interaction partners:
- L-rhamnose isomerase
- Rhamnulose-1-phosphate aldolase
- L-rhamnose mutarotase
- HTH-type transcriptional activator RhaR
- Ribulokinase
- L-rhamnose-proton symporter
- L-ribulose-5-phosphate 4-epimerase AraD
- L-xylulose/3-keto-L-gulonate kinase
- HTH-type transcriptional activator RhaS
- L-fucose isomerase
Sequence:
MTFRNCVAVDLGASSGRVMLARYERECRSLTLREIHRFNNGLHSQNGYVTWDVDSLESAIRLGLNKVCEEGIRIDSIGIDTWGVDFVLLDQQGQRVGLPVAYRDSRTNGLMAQAQQQLGKRDIYQRSGIQFLPFNTLYQLRALTEQQPELIPHIAHALLMPDYFSYRLTGKMNWEYTNATTTQLVNINSDDWDESLLAWSGANKAWFGRPTHPGNVIGHWICPQGNEIPVVAVASHDTASAVIASPLNGSRAAYLSSGTWSLMGFESQTPFTNDTALAANITNEGGAEGRYRVLKNIMGLWLLQRVLQEQQINDLPALISATQALPACRFIINPNDDRFINPETMCSEIQAACRETAQPIPESDAELARCIFDSLALLYADVLHELAQLRGEDFSQLHIVGGGCQNTLLNQLCADACGIRVIAGPVEASTLGNIGIQLMTLDELNNVDDFRQVVSTTANLTTFTPNPDSEIAHYVAQIHSTRQTKELCA
Protein: Tubby-like F-box protein 9 (AtTLP9) (Q9SQU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Confers sensitivity to ABA during seed germination and early seedling development.
Interaction partners:
- SKP1-like protein 1A
- Probable E3 ubiquitin-protein ligase XERICO
- F-box protein At1g30200
- F-box/kelch-repeat protein At5g60570
- E3 ubiquitin-protein ligase RMA1
- Elongin-C
- At5g27920
- Probable methyltransferase PMT24
- AT3G11930 protein
- Protein LIKE COV 2
Sequence:
MTFRSLLQEMRSRPHRVVHAAASTANSSDPFSWSELPEELLREILIRVETVDGGDWPSRRNVVACAGVCRSWRILTKEIVAVPEFSSKLTFPISLKQSGPRDSLVQCFIKRNRNTQSYHLYLGLTTSLTDNGKFLLAASKLKRATCTDYIISLRSDDISKRSNAYLGRMRSNFLGTKFTVFDGSQTGAAKMQKSRSSNFIKVSPRVPQGSYPIAHISYELNVLGSRGPRRMRCIMDTIPMSIVESRGVVASTSISSFSSRSSPVFRSHSKPLRSNSASCSDSGNNLGDPPLVLSNKAPRWHEQLRCWCLNFHGRVTVASVKNFQLVAVSDCEAGQTSERIILQFGKVGKDMFTMDYGYPISAFQAFAICLSSFETRIACE
Protein: Shugoshin-2 (O13734)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in chromosome cohesion during mitosis and meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for faithful mitotic chromosome segregation and proper kinetochore orientation during meiosis I. In contrast to sgo1, it is dispensable for centromeric protection of rec8 during meiosis I as well as protection of rad21 during mitosis. Required to sense the lack of tension at centromeres during mitosis.
Subcellular location: Chromosome, centromere {ECO:0000269|PubMed:14730319, ECO:0000269|PubMed:14972679}. Note=Localizes to the centromere. Bub1 is required for centromeric localization (PubMed:14730319). At the onset of anaphase I, Sgo1 decreases markedly (PubMed:14730319). {ECO:0000269|PubMed:14730319}.
Interaction partners:
- Chromosomal passenger complex protein bir1
Sequence:
MSKASLSPNVEDLKKKQIRQYKEIIRISKAQSIRIKELQLENERLLSENIDLRTTAINLEEQLETVQNENEENKTKLAALLNRFHEETDNFLSKLSLCQQEIQDTFKPVEANLAYDVDTDSEDLDEESVVKDTEEIIEQAQHDVSLRNLSGIEDENIIDDGETAINEQKKREANVFSDTQSAPQLKSGKALPADFENPYNLSNSKPVNNNNEDRVEAVTSENKSIDSAPQEKNHEYEIVSPKSLSNKINNQAAAQRRTEEDNANGVAQEENEGSQEAHFHSRIQSDTVIQSTPTKRKWDVDIQNKQINLASAATNVTGYVSETDSRPNRANSLDSAVLLVQSSNKSNRNGHHISDPNLNSSISLKFAPEDTAHNSLTSQENVGPQVTTTSLSNMTVAESPRTDTPREINGLVDSSVTNGNEKFSVEIMNDSNKIGLNPKSFTDEEREILTLFRNPPMRLSSEPPSSNGFSIAHPNNSPLRPPSLQGILNAEDRPYEIEPSRSSFATNDTGSYNNLELLSSVTNLKSPNENDRVTKTQSRRETKVKRRRKARIQETSEESTVVNEPNEKPDGRSRRERKKVNYALPGLRTKLRRNFDLPSDHVKAKKTRRAPKNSENDSATKTETANITSEAPTTSEVTLENSETLNL
Protein: DNA repair helicase/translocase XPB-R (EC 5.6.2.4) (DNA 3'-5' helicase/translocase XPB-R) (Q381F9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: ATP-dependent 3'-5' DNA helicase involved in nucleotide excision repair (NER) of damaged DNA. XPB-R is a paralog of XBP, but is not a component of the TFIIH basal transcription factor and is dispensable for RNA polymerase II transcription.
Interaction partners:
- General transcription factor IIH subunit 4
- DNA 5'-3' helicase
- DNA repair and transcription factor protein, putative
- [RNA-polymerase]-subunit kinase
- Telomerase-associated protein, putative
- DNA-repair protein, putative
- DNA excision repair protein, putative
- TFIIH basal transcription factor complex helicase/translocase XPB subunit
- TATA box-binding protein-like 1
- DNA repair protein, putative
Sequence:
MQCLFLEERIKKEGCVVLFAEAFRPSFANIQGFLTTIAEPVSRLSLMHEYRMTYFSLGAAASASISVSEVIQFLDDHVYFFRDKCFASYRESVCAFAEMYMSRCNLARVVIDESRTLLECKDIVTAKTLLKDRVVRSLCCQPKETVGEDACPHFLLKSRAAARVVAERCVLLGYPLQQQYEYEKDTSIRNVNIALKSQTRPRPYQIAAVDAAASDGALRSGCIVLPCGSGKTLVGIMLLCKVKKPTLILCAGGVSVEQWRNQILEFASVCAPANNEEGDPSNSTTGEKVRTAAVGAARISCLTGKQKDEITDETDIVLTTYSMLVTAHKAQARCQVEGFEMNADGRGRNPRRANPKERLFQPYGLLIMDEVHMMPADAYKDSLGFINAKGVVGLTATYVREDSKIRDLFHLVGPKLFDISWERLASSGYLAHVTCIEVLTPLARRFSLEYLERSSELTSPQHGTPLLVMLAAANPNKMLCVMEIVKRHVAESSKILVFCDHIMLLKEYSKLLGAPVVCGDTPHRERLMIFSDFQSTSKVNVVCLSRVGDVSVNLPSANVVVQVSSHGGSRRQEAQRLGRILRPKEKASNGKPTDAWFYTVISTDTVEMSYAAHRTAFLVDQGYTCSVTEFNPDGAPEAAVEGVDDTAPGDVVSIRQAKLRGTFKKQELKCSVASPTAQGSVNPRSLDYQEKLLCRVVASWELDYQNATSQQNEPGVANDTATGLIDKKMKRARDETAEDIKREWNSGAQTTQPRGDFCRLPLQRLVGANDDVVYHES
Protein: Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (mPCl2) (Zinc-regulated factor 1) (ZiRF1) (Q02395)
Organism: Mus musculus (Mouse)
Function: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter.
Subcellular location: Nucleus {ECO:0000269|PubMed:21367819}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:21367819}.
Interaction partners:
- Protein Jumonji
- Polycomb protein Suz12
- Histone-lysine N-methyltransferase EZH2
- Elongin BC and Polycomb repressive complex 2-associated protein
- Polycomb protein EED
- Zinc finger protein AEBP2
- PHD finger protein 19
- Histone-binding protein RBBP4
- PHD finger protein 1
- Histone-binding protein RBBP7
Sequence:
MRDSTGAGNSLVHKRSPLRRNQKTSASLNKLSLQDGHKAKKPACKFEEGQDVLARWSDGLFYLGTIKKINILKQSCFIIFEDSSKSWVLWKDIQTGATGSGEMVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEKWLCRQCVFATTTKRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDIAHLCLYNLSVIHKKKYFDSELELMTYINENWDRLHPGELADTPKSERYEHVLEALNDYKTMFMSGKEIKKKKHLFGLRIRVPPVPPNVAFKAEKEPEGTSHEFKIKGRKASKPTSDSREVSNGIEKKGKKKSVGRPPGPYTRKMIQKTAELPLDKESVSENPTLDLPCSIGRTEGIAHSSNTSDVDLTGASSANETTSASISRHCGLSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEVVKDDEGKEDYQFEELNTEILNNLADQELQLNHLKNSITSYFGAAGRIACGEKYRVLARRVTLDGKVQYLVEWEGATAS
Protein: Photosystem I assembly protein Ycf4 (P0C515)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Seems to be required for the assembly of the photosystem I complex.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00437}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00437}.
Interaction partners:
- Photosystem II CP43 reaction center protein
- Potassium/proton antiporter CemA
- Cytochrome b559 subunit alpha
- Photosystem II reaction center protein H
- Photosystem II D2 protein
- Photosystem II reaction center protein K
- Photosystem II CP47 reaction center protein
- Photosystem I P700 chlorophyll a apoprotein A1
- Photosystem I assembly protein Ycf3
- Photosystem I P700 chlorophyll a apoprotein A2
Sequence:
MNWRSEHIWIELLKGSRKRGNFFWACILFLGSLGFLAVGASSYLGKNIISVLPSQQILFFPQGVVMSFYGIAGLFISAYLWCTILWNVGSGYDRFDRKEGVVCIFRWGFPGIKRRVFLRFLMRDIQSIRIQVKEGLFPRRILYMEIRGQGAIPLTRTDEKFFTPREIEQKAAELAYFLRIPMEVF
Protein: Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (QM protein homolog) (dQM) (O61231)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL30
- 40S ribosomal protein S15
- Ribosomal protein S30, isoform A
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein eL14
Sequence:
MGRRPARCYRYCKNKPYPKSRFCRGVPDPKIRIFDLGRKKATVEDFPLCVHLVSDEYEQLSSEALEAGRICCNKYLVKYCGKDQFHIRMRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVRIGQPIMSVRSSDRYKAQVIEALRRAKFKFPGRQKIYVSKKWGFTKYERERYEELRDDNRLEPDGCNVKYRPEHGPIAAWEKAQRDVYA
Protein: Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase (EC 2.2.1.11) (EC 4.1.2.13) (DKFP synthase) (Fructose-bisphosphate aldolase class 1) (Fructose-bisphosphate aldolase class I) (FBP aldolase) (Q58980)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Catalyzes the transaldolization of either fructose-1-P or fructose-1,6-bisphosphate with methylglyoxal to produce 6-deoxy-5-ketofructose-1-phosphate (DKFP). Also catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P or GAP) to produce fructose 1,6-bisphosphate (FBP).
Interaction partners:
- Triosephosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase
- 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
- Probable transaldolase
- Bifunctional ADP-specific glucokinase/phosphofructokinase
- Fructose-1,6-bisphosphate aldolase/phosphatase
- L-fuculose phosphate aldolase
- Uncharacterized protein MJ1185
- Putative transketolase C-terminal section
- Putative transketolase N-terminal section
Sequence:
MGIFMIKRLKKRDVKVPLTVPEDRKEEYIKNYLELTKRTGNVMLFAGDQKIEHLNDDFFGEGIAKDDASPEHLFNIASKGKICGFATQLGLIARYGMDYKKIPYIVKINSKTHLVKTRDPISRALVHVKDVVDLKENSGLKILGVGYTIYPGSEYEHIMFEEASRVILEAHKHGLIAIIWSYPRGKNVKDEKDPHLIAGAAGVAACLGADFVKVNYPKCDNPAERFKEAVLAAGRTGVLCAGGKSIEPEKFLKQIWEQINISGARGNATGRNIHQKPLDAAIRMCNAIYAITIEGKSLEEALKIYYGDRK
Protein: Glial fibrillary acidic protein (K7EPI4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
KLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVRRDLGPVRLWLAPGILKARPWRKAWGWHIEGSQQLPVAPQGILEESKETECNSVSSVPP
Protein: Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) (A0A0R4IYN3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAVSRRSSQHQQSSLQPSPRNAVIASPPPESPSAIIPDSASLLSPSATGAAECGASTMESAAASSASASSPDRPAPVTAAAAGGPSVLGSSSCSSISSSATAGSQSPGSGAASPGEAVCGAGGAFRELFEACRNGDVSRVKRLVDSVNVNAKDMAGRKSTPLHFAAGFGRKDVVEHLLQTGANVHSRDDGGLIPLHNACSFGHAEVVSLLLCSGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKTVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTSQKMLSTPLHLAAGYNRVRIVQLLLQYGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLLNCHGKSAVDVAPTPELKERLTYEFKGHSLLQAAREADMAKVKKTAQEIISFKHPHSHDSALHCAVASPHPKRKQVTELLLRKGANIHEKNKDFMTPFHVAAERGHNDVLEVLQKHGAKVNAADTLGQTALHRAALAGHIQTCRLLLSYGADPSIVSLQGFTASQMGNEAVQQILNENVPPRNSDVDYRLLEAAKAGDLDTVKQLCSPQNVNCRDLEGRHSTPLHFAAGYNRVAVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPSKKNRDGNMALDMVKDGDTDIQDLLRGDAALLDAAKKGCLARVQKLCSPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKFNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGANPTMKNQEGQTALDLATADDIRALLMDAMPPDALPSCFKPQATVLSAALISPASTPSCLSAASSIDNLAGPLCDGASGGAAGPADGASSTDRKEGDAVLDMNISQFLKSLGLEHLRDIFEREQITLDVLADMGHEELKEIGINAYGHRHKLIKGIERLLGGQQGANPYLTFHCTNQGTVLIDLAVDDKEFQSVEEEMQSTIREHRDGGNAGGVFSRYNVIKIQKVVNKKLRERYTHRQKEIADENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYLCHRQMLFCRVTLGKSFLQFSAMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPDSTPQSSTGAEQKS
Protein: Casein kinase I isoform alpha (CKI-alpha) (DmCK1) (EC 2.7.11.1) (P54367)
Organism: Drosophila melanogaster (Fruit fly)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Negative regulator of wg signaling. Phosphorylates arm directly or indirectly and stimulates its degradation which prevents inappropriate wg signaling. Phosphorylates smo which promotes its accumulation at the cell surface and its signaling activity in response to hh. Together with dco, regulates proteolytic processing of ci by phosphorylating it, which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase required for ci processing. Inhibits condensin II interphase activity by promoting degradation of the Cap-H2 regulatory subunit and limiting the levels of chromatin-bound Cap-H2 which regulates interphase chromosome organization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15691767, ECO:0000269|PubMed:8832407}. Nucleus {ECO:0000269|PubMed:15691767, ECO:0000269|PubMed:8832407}. Note=Levels in the nucleus are significantly increased after DNA damage. {ECO:0000269|PubMed:8832407}.
Interaction partners:
- Axin
- Armadillo segment polarity protein
- Transcriptional activator cubitus interruptus
- Protein kinase shaggy
- Protein smoothened
- Kinesin-like protein costa
- Discs overgrown protein kinase
- Segment polarity protein dishevelled
- Supernumerary limbs, isoform B
- cAMP-dependent protein kinase catalytic subunit 1
Sequence:
MDKMRILKESRPEIIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAILLEQLDKDKEKQNGKPLIAD
Protein: Peptidoglycan recognition protein 6 (A0A060Y1K9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Uncharacterized protein
- Peptidoglycan-recognition protein
- Phosphatidylinositol glycan anchor biosynthesis class U protein
- Phosphatidylinositol glycan anchor biosynthesis class U protein
- L-serine ammonia-lyase
- L-serine deaminase
- L-serine deaminase
- L-serine dehydratase/L-threonine deaminase
- L-serine deaminase
- L-serine ammonia-lyase
Sequence:
MEPHWKWCLTLLVILVSAHTDTKVTSSQHMDDFIRVLEQVEDSNPGLEPVNVLRGLRRAAGLRDEFMQHFLGTIREDSTSEAPVMDSNLSDFIVRAMRHKVTERGREEGVVLTADGTTVAMSPVLLGIEAGLVSKTRCRVRGLYPLTLARNLGLSFQRFHSSLLSQRLGPDGCWDDVTSPQVFTLSDKPSLATDALVNGGMDGVILGIEVSAQSQRPLKLSSLLRRYYCHRLEGEGLDAAPRLISHLRRENFRELARPPLLQRQVVRSLVLQRRLIDHSTMLSQEKEELTAVVREGIKEFVHRYMDCPAIIPRCQWGAAPYRGTPTPLSLPLSFMYIHHTYQPGQPCLTFQQCSADMRSMQRFHQDDRGWDDIGYSFVAGSDGYLYEGRGWHWQGAHTKGYNSKGYGVSFIGDYTSSLPSEQTMELVRDRLASCAVGGGRLVGNFTLYGHRQLVKTSCPGDAFYSEITGWEHFGEVQN
Protein: Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) (Q15477)
Organism: Homo sapiens (Human)
Function: Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).
Subcellular location: Nucleus {ECO:0000269|PubMed:16024656}. Cytoplasm {ECO:0000269|PubMed:16024656}.
Interaction partners:
- Superkiller complex protein 8
- Superkiller complex protein 3
- Exosome complex component RRP41
- Exosome complex component CSL4
- Exosome complex component RRP46
- Exosome complex component RRP42
- Exosome complex component RRP40
- Exosome complex component MTR3
- 5'-3' exoribonuclease 1
- Exosome complex component RRP43
Sequence:
MMETERLVLPPPDPLDLPLRAVELGCTGHWELLNLPGAPESSLPHGLPPCAPDLQQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAVLGAPVPSDLQAQRHPTTGQILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPTITDLNTREEAEEEIDFEKDLLTIPPGFKKGMDFAPKDCPTPAPGLLSLSCMLEPLDLGGGDEDENEAVGQPGGPRGDTVSASPCSAPLARASSLEDLVLKEASTAVSTPEAPEPPSQEQWAIPVDATSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDVERGVVWEEVLIMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALAELTKRLGALEEPDMTGQLVDLPEYYSWGEELTETQHMIQRRIMESVNGLKSLSAGRVVVVKNQEHHNALGVILQVSSNSTSRVFTTLVLCDKPLSQDPQDRGPATAEVPYPDDLVGFKLFLPEGPCDHTVVKLQPGDMAAITTKVLRVNGEKILEDFSKRQQPKFKKDPPLAAVTTAVQELLRLAQAHPAGPPTLDPVNDLQLKDMSVVEGGLRARKLEELIQGAQCVHSPRFPAQYLKLRERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSTLRPEEIAALLSGLVCQSPGDAGDQLPNTLKQGIERVRAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ
Protein: RAP1 GTPase activating protein 2 (A0A1B0GV05)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGRRAPGEKRWQLVRWYVQEGRFRIEERTLTAFQWLYSPQQHRILSRADLESPSRIDKTMLASLKVKKQELANSSDATLPDRPLSPPLTAPPTMKSSEFFEMLEKMQGIKLEEQKPGPQKNKDDYIPYPSIDEVVEKGGPYPQVILPQFGGYWIEDPENVGTPTSLGSSICEEEEEDNLSPNTFGYKLECKGEARAYRRHFLGKDHLNFYCTGSSLGNLILSVKCEEAEGIEYLRVILRSKLKTVHERIPLAGLSKLPSVPQIAKAFCDDAVGLRFNPVLYPKASQMIVSYDEHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNLHDELHAHTQAMLGLGPEEDKFENGGHGGFLESFKRAIRVRSHSMETMVGGQKKSHSGGIPGSLSGGISHNSMEVTKTTFSPPVVAATVKNQSRSPIKRRSGLFPRLHTGSEGQGDSRARCDSTSSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKEKPFMKLKENGRAISRSSSSTSSVSSTAGEGEAMEEGDSGGSQPSTTSPFKQEVFVYSPSPSSESPSLGAAATPIIMSRSPTDAKSRNSPRSNLKFRFDKLSHASSGAGH