wanglab/gogpt-training-data huggingface dataset:
Protein: Outer membrane usher protein PapC (P07110)
Organism: Escherichia coli
Function: Involved in the export and assembly of pili subunits across the outer membrane. Forms a hexameric ring-shaped pore in the outer bacterial membrane. The 2 nanometer-diameter pore allows the passage of the thin tip fibrillum. As for the rod, it probably unwinds into linear fibers which would therefore be narrow enough to pass through the pore.
Subcellular location: Cell outer membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MKDRIPFAVNNITCVILLSLFCNAASAVEFNTDVLDAADKKNIDFTRFSEAGYVLPGQYLLDVIVNGQSISPASLQISFVEPALSGDKAEKKLPQACLTSDMVRLMGLTAESLDKVVYWHDGQCADFHGLPGVDIRPDTGAGVLRINMPQAWLEYSDATWLPPSRWDDGIPGLMLDYNLNGTVSRNYQGGDSHQFSYNGTVGGNLGPWRLRADYQGSQEQSRYNGEKTTNRNFTWSRFYLFRAIPRWRANLTLGENNINSDIFRSWSYTGASLESDDRMLPPRLRGYAPQITGIAETNARVVVSQQGRVLYDSMVPAGPFSIQDLDSSVRGRLDVEVIEQNGRKKTFQVDTASVPYLTRPGQVRYKLVSGRSRGYGHETEGPVFATGEASWGLSNQWSLYGGAVLAGDYNALAAGAGWDLGVPGTLSADITQSVARIEGERTFQGKSWRLSYSKRFDNADADITFAGYRFSERNYMTMEQYLNARYRNDYSSREKEMYTVTLNKNVADWNTSFNLQYSRQTYWDIRKTDYYTVSVNRYFNVFGLQGVAVGLSASRSKYLGRDNDSAYLRISVPLGTGTASYSGSMSNDRYVNMAGYTDTFNDGLDSYSLNAGLNSGGGLTSQRQINAYYSHRSPLANLSANIASLQKGYTSFGVSASGGATITGKGAALHAGGMSGGTRLLVDTDGVGGVPVDGGQVVTNRWGTGVVTDISSYYRNTTSVDLKRLPDDVEATRSVVESALTEGAIGYRKFSVLKGKRLFAILRLADGSQPPFGASVTSEKGRELGMVADEGLAWLSGVTPGETLSVNWDGKIQCQVNVPETAISDQQLLLPCTPQK
Protein: Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Cytochrome c1 non-heme 7.3 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.3 kDa protein) (O74433)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}. Mitochondrion inner membrane {ECO:0000269|PubMed:37939086}; Single-pass membrane protein {ECO:0000269|PubMed:37939086}.
Interaction partners:
- Cytochrome b-c1 complex subunit 10
- Cytochrome b
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c oxidase subunit 12, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 7
- Probable mitochondrial-processing peptidase subunit beta
- Cytochrome c oxidase subunit 4, mitochondrial
Sequence:
MASSTIYNIFFRRNSSFYATIFVSAFFAKIGFDVFTDSVWKRANAGLTWDEVKPRFLNKDEDAEDDE
Protein: Nuclear pore complex interacting protein family member B7 (A0A494C1T1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRLRFWLLIWLLLGFISHQPTPVSFLKTIFWSRNGHDGSMDVQQRAWRSNRSRQKGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKRKVTTKINRHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKPLCNWVRMAAAEHCHSSGLPYWLYLTAETLKNRMGRQPPPPTQQHSITDNSLSLKTPPECLLTPLPPSVDDNIKECPLAPLPPSPLPPSVDDNLKECLFVPLPPSPLPPSVDDNLKECLFVPLPPSPLPPSVDDNLKTPPLATQEAEVEKPPKPKRWRVDEVEQSPKPKRQREAEAQQLPKPKRRRLSKLRTRHCTQAWAIRINP
Protein: Bifunctional urea carboxylase/allophanate hydrolase (A0A1D8PDC6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Biotin--[acetyl-CoA-carboxylase] ligase
- Arginase
- Pyruvate dehydrogenase E1 component subunit beta
- [acyl-carrier-protein] S-malonyltransferase
- cyanamide hydratase
- Transcription elongation factor SPT5
- 3-oxoacyl-[acyl-carrier-protein] synthase
- Glutamyl-tRNA
- 4-hydroxyphenylpyruvate dioxygenase
- ATP synthase assembly factor FMC1
Sequence:
MSYLGWSVEDWKKFHYESTPDESFELLSQLLKSQKAAPEDPAWISLASIENLEHQWKFLQSKSNKRDLPLYGVPIAVKDNIDAKTFETTAACPSFAYSPSKDATTVRLLRDAGAIVIGKTNLDQFATGLVGTRSPYGITPNTFNPKYVSGGSSAGSASVVARGIVPIALGTDTAGSGRVPAALNNLIGLKPTKGVFSCSGVVPACKSLDCVSIFALNLQDAQLTFNIMAEEDEHDEFSRSMPKNPLLKFGKKPRVVVPTNLLWYGEKENPKLYQEAVAKFEKIGCELVSLDIEPLLELARCLYEGPWVAERYVAVKDFFATNTPEKDLDPTVTKIIKGGEHYSAATCFQYEYKRQGIVKRVNKLLEGIDAIIVPTAPLNPTIEEVTNEPIKVNSCQGTYTNFVNLADMSALAIPAGFRNDGLPFGVTLLSHKFNDYALLDLASRYLKLDNLRTCGVSQKKVSTIHDELYLLPKSTPEETVKLAVVGAHLKGFELHWQLEKVDARFIESTTTSKNYKLYALPKTGPVAKPGLRRVESDGEHIAVETYSIPKEKFGQFIKFVPEPLGIGSVELKSGEWCKSFICEEFGYKQPGTVDITEFGGWKKYQEHLRASKKPFNSVLVANRGEIAVRIIKTLKKLGVKSIAVYSDPDKYAQHSLMADVAIPLHGTTAAETYINIEKVIKAAKESGAEAIIPGYGFLSENADFSDRCGKEGIVFVGPSGDAIRKLGLKHSAREIAEKAGVPLVPGSGLVKDAKEARAIAAKLEYPIMVKSTAGGGGIGLQKVDSEKDIERVFETVQHQGKSYFGDSGVFLERFVENARHVEIQMLGDGYGNAIAVGERDCSLQRRNQKIIEETPAPNLPEETRNKMRKAAESLGSSMKYKCAGTVEYIYDPKRDEFYFLEVNARLQVEHPITEMVTGLDLVEWMLLIAADTPPDFNQKIEVKGASMEARLYAENPVKGFMPSPGQLTEVKFPEWARIDSWVEKGTIVSAEYDPTLAKIIVHGKDRDDALKKLRQALNETVVYGCITNVDYLRSIANSKMFEEAAVATKVLDSYDYKPHAIEILQPGAYTTVQDYPGRRGYWHIGVPPSGCMDQYSFRVANKIVGNDAASPGIEITLNGPKLLFHQDCVVAVTGGKTKVEVNQVEVNQWEPINIKSGDKLDIGKLSTGCRAYLAIRGGVDVVEYLGSRSTFALGNLGGYNGRVLKLGDVLFLGQPDVTSCTLPGPISQPTPVPASLIPNYDNKVWKIGVTCGPHGSPDFFKAESVEEFFSSTWKVHYNSNRFGVRLIGPKPKWARKDGGEGGLHPSNTHDYVYSMGAINFTGDEPVILTCDGPSLGGFVCEAVVAESELWKVGQVKPGESIQFVPISYESAKNLKKQQNAAIENLSGDLPSLETVSLSAPENPILHQFKVSSNAPKVTYRQAGDRYILVEYGDNLLDLNLAYRIHKLDAMVKEYKPKGIFELSAGVRSVLVEYTDEITQKEALDTLVSYEKEIIFVNKWKVSSRIIKLPMAFEDKKTLDAVKRYQETIRSEAPWLPNNVDFIANINGITRTDVKDMLYTARFLVLGLGDVFLGAPCAVPLDPRHRLLGTKYNPSRTFTPNGTVGIGGNYMCIYTMESPGGYQLVGRTVPIWDKLSLGEHSPNTKPWLLSPFDQIEFYPVTEEEVDAFSEQMNAGKFKVDIVESVFDHGKYLEWIQENSKSIEEFQQNQGGEKLEEFNRLIQISNSELEKSGTKVQDDEKFDDNAELVYSEYSGRFWKSVVEVGDKVTAHQPLIVVEAMKTEMVVNAPRDGKVLKIYHKNGDMVEAGDLVVVLE
Protein: Pre-mRNA-processing protein 40C (AtPRP40c) (Transcription elongation regulator 1) (Q9LT25)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds the phosphorylated C-terminal domain (CTD) of the largest subunit of RNA polymerase II and functions as a scaffold for RNA processing machineries (Probable). May be involved in pre-mRNA splicing (Probable).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-splicing factor 38
- Nuclear protein-like
- Cwf15 / Cwc15 cell cycle control family protein
- Cell division cycle 5-like protein
- Splicing factor SF3a60 homolog
- U2 small nuclear ribonucleoprotein A'
- Small nuclear ribonucleoprotein Sm D2
- At3g05070
- Pre-mRNA-splicing factor SPF27 homolog
- Microfibril-associated protein-like
Sequence:
MEGENTTDPPYTTAASSGQSIFVRPPPIAPVLATTSNFSQSELKELHSMSIASTGFVSQSVPYSVTAQWGTNAAASSNVNPIPQASPMLANAPFGRPGTLAPPGLMTSPPAFPGSNPFSTTPRPGMSAGPAQMNPGIHPHMYPPYHSLPGTPQGMWLQPPSMGGIPRAPFLSHPTTFPGSYPFPVRGISPNLPYSGSHPLGASPMGSVGNVHALPGRQPDISPGRKTEELSGIDDRAGSQLVGNRLDAWTAHKSEAGVLYYYNSVTGQSTYEKPPGFGGEPDKVPVQPIPVSMESLPGTDWALVSTNDGKKYYYNNKTKVSSWQIPAEVKDFGKKLEERAMESVASVPSADLTEKGSDLTSLSAPAISNGGRDAASLKTTNFGSSALDLVKKKLHDSGMPVSSTITSEANSGKTTEVTPSGESGNSTGKVKDAPGAGALSDSSSDSEDEDSGPSKEECSKQFKEMLKERGIAPFSKWEKELPKIIFDPRFKAIPSHSVRRSLFEQYVKTRAEEERREKRAAHKAAIEGFRQLLDDASTDIDQHTDYRAFKKKWGNDLRFEAIERKEREGLLNERVLSLKRSAEQKAQEIRAAAASDFKTMLREREISINSHWSKVKDSLRNEPRYRSVAHEDREVFYYEYIAELKAAQRGDDHEMKARDEEDKLRERERELRKRKEREVQEVERVRQKIRRKEASSSYQALLVEKIRDPEASWTESKPILERDPQKRASNPDLEPADKEKLFRDHVKSLYERCVHDFKALLAEALSSEAATLQTEDGKTALNSWSTAKQVLKPDIRYSKMPRQDREVVWRRYVEDISRKQRHENYQEEKQRDYKT
Protein: Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) (Q6UXM1)
Organism: Homo sapiens (Human)
Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. {ECO:0000250}.
Interaction partners:
- Galactosylceramide sulfotransferase
- Leucine-rich repeats and immunoglobulin-like domains protein 1
- Epidermal growth factor receptor
- Sodium-dependent phosphate transport protein 2B
- Proto-oncogene tyrosine-protein kinase ROS
- ER lumen protein-retaining receptor 2
Sequence:
MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT
Protein: Septin-4 (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2) (O43236)
Organism: Homo sapiens (Human)
Function: Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (By similarity). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (By similarity). Plays an important role in male fertility and sperm motility (By similarity). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P28661}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25588830}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:15116257}. Cell projection, axon {ECO:0000250|UniProtKB:P28661}. Cell projection, dendrite {ECO:0000250|UniProtKB:P28661}. Perikaryon {ECO:0000250|UniProtKB:P28661}. Synapse {ECO:0000269|PubMed:17296554}. Note=In platelets, found in areas surrounding alpha-granules (PubMed:15116257). Found in the sperm annulus, a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum (PubMed:25588830). Expressed and colocalized with SLC6A3 and SNCA in axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:P28661, ECO:0000269|PubMed:15116257, ECO:0000269|PubMed:25588830}.; SUBCELLULAR LOCATION: [Isoform ARTS]: Mitochondrion {ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247, ECO:0000269|PubMed:21695558}. Nucleus {ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247}. Note=While predominantly localized in the mitochondria under resting conditions, translocates into the nucleus after TGF-beta treatment and apoptosis induction. {ECO:0000269|PubMed:11146656}.
Interaction partners:
Sequence:
MDRSLGWQGNSVPEDRTEAGIKRFLEDTTDDGELSKFVKDFSGNASCHPPEAKTWASRPQVPEPRPQAPDLYDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY
Protein: guanylate kinase (EC 2.7.4.8) (A0A8I6A2B3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLRRPLVGLAVAALGRVPVDDSWSRISLFPFILAGKRHKRRWVAPGRCSSLFVVSRCSSTSTLLGGHGMAGPRPVVLSGPSGAGKSTLLKKLFQEHGSVFGFSVSHTTRNPRPGEEDGKDYYFVTREMMQRDIAAGDFIEHAEFSGNLYGTSKEAVRAVQAMNRICVLDVDLQGVRSIKKTDLHPIYISVQPPSMDVLEQRLRQRNTETEESLAKRLAAAQADMESSKEPGLFDLVIVNDNLDEAYVTLKQALSEEIKKAEGTEHA
Protein: LUD domain-containing protein (Q726S4)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Iron-sulfur cluster-binding protein
- Glycolate oxidase iron-sulfur subunit
- DRTGG domain-containing protein
- Acetate kinase
- Phosphate acetyltransferase
- Iron-sulfur cluster-binding protein
- Cysteine-rich domain protein
- Glycolate oxidase, iron-sulfur subunit, putative
- D-lactate dehydrogenase
- Oxidoreductase, FAD/iron-sulfur cluster-binding domain protein
Sequence:
MSGNQDLARLMREKAEAIAATVVELKDINEAFAYALDICEKKEACQLLISGCEEKLSDNAEALCEMKQKKIIAAPNLSDKEYDAFAKLCEERGIACVREGLRKHLAGIDIGFTHVTMGIAETGTCVVSSNSEELRLASMISEFHVAVLPKSKIVATSYDAEATLNELMGTGKPHYTAFISGPSRTADIERVLSLGVHGPLELHLILVEG
Protein: Effector cell protease receptor 1 (Q14868)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTSRGFQRSCNNPPCSSMTGRRANQIHHLTPDFSLRELLPPKKAGTWADCVSPPCGERDRCEGWADRHTACSSPASTCQVHTQDCDSLNNMRSRHIHCGRLCHANKAVSSSKRDTAFFLPHFSPGKPGNQNSKNEPPKKRERERSSHCYPAAPAAQAEAPLVPLSRQNKSTVETSNLKMLISFPKTLLRGPQEGWWHQGINPGSGAATLGPGSSERPQSIEASCSMARRTFFAVSSNSFFLLLVSFAILFLALSLSSFKNSPRVNSSNCFLTERKAQPDECFLCSSMGSSSGSQPSSSLKQKKHWAKSGSFSVGQWMKPASAIRSGVQRSPPRRASS
Protein: Interferon-induced GTP-binding protein Mx1 (Influenza resistance protein) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) (P09922)
Organism: Mus musculus (Mouse)
Function: Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV), influenza B virus (IBV) and Thogoto virus (THOV). Inhibits FLUAV by interfering with the process of primary transcription, probably by affecting the viral polymerase function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21859714}. Nucleus {ECO:0000269|PubMed:21859714}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P20591}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20591}; Cytoplasmic side {ECO:0000250|UniProtKB:P20591}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P20591}. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region. {ECO:0000250|UniProtKB:P20591}.
Interaction partners:
Sequence:
MDSVNNLCRHYEEKVRPCIDLIDTLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLRKLKEGEEWRGKVSYDDIEVELSDPSEVEEAINKGQNFIAGVGLGISDKLISLDVSSPNVPDLTLIDLPGITRVAVGNQPADIGRQIKRLIKTYIQKQETINLVVVPSNVDIATTEALSMAQEVDPEGDRTIGVLTKPDLVDRGAEGKVLDVMRNLVYPLKKGYMIVKCRGQQDIQEQLSLTEAFQKEQVFFKDHSYFSILLEDGKATVPCLAERLTEELTSHICKSLPLLEDQINSSHQSASEELQKYGADIPEDDRTRMSFLVNKISAFNRNIMNLIQAQETVSEGDSRLFTKLRNEFLAWDDHIEEYFKKDSPEVQSKMKEFENQYRGRELPGFVDYKAFESIIKKRVKALEESAVNMLRRVTKMVQTAFVKILSNDFGDFLNLCCTAKSKIKEIRLNQEKEAENLIRLHFQMEQIVYCQDQVYKETLKTIREKEAEKEKTKALINPATFQNNSQFPQKGLTTTEMTQHLKAYYQECRRNIGRQIPLIIQYFILKTFGEEIEKMMLQLLQDTSKCSWFLEEQSDTREKKKFLKRRLLRLDEARQKLAKFSD
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (E9PGC5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKRRSYYSYSYYLKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS
Protein: FI07835p (GTPase activating protein, SECIS-dependent read-through) (Q9VSM8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD21953p
- Cytosol aminopeptidase
Sequence:
MSIFKARVKEFEDVLAGPQDLIDLKQLRKLAFNGVPDVQSFRALSWKLLLGYLGPRRSSWTTTLAQKRALYKQFIEELVLPPGHSSNRASVDGGDGDKVDSGGVGLQDHPLSEGPESAWNTFFNDNEFLLQIDKDVRRLCPDISFFQQPTDYPCEIVVHSKGEHGRRLHERVVPAVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEVVQRILFIYAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSEIRDFFIKTLDDAEGGIKFMMARLSNMLKSKDLSIYELLRSQELHPQYYSFRWLTLLLSQEFPLPDVLRIWDSVFADEQRFDFLIKICCSMILIQREAILENDFASNVKLLQNYPPIDINVVIAHAGSLA
Protein: Relative of woc, isoform C (A0A0B4KER0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Heterochromatin protein 1c
- MIP09469p
- Without children, isoform B
- Zinc finger protein indra
Sequence:
MTRVTRSEISLDMEFWVEELSPAQLAYYEKITNEHNAVKGALKNAVSANEGKELFNGQVFQAYSFKGKVLQELKEATLPKKPPKPTDSPSTPAAQSGGTGRGRGRPPRQPSNIAYLESSDEGDDDMPLAKRLALSAGKKAVAVANASSSFTPKSSKKAASAASGGSSSPVPKSSGKLFKESKPDIESPPKNYRPAEVNSVGGLVVGSTDESKDSKDGKDGKDNKMQGKTYPSLVVLAKPFLKIKDMAATRSKLDSKVKLVLMLTPNKFCEWLLQEGLLRAQQHCINHRNNELKLGIYSDVTKFPYTGGYVWISECCPYRFVSVFNNSIFEGAQHPPTFLLKLIYHWACQTSIQNVVQWVKVDSVYIKGIYTWLRAICTLAVHQKCKKLGGPGKFVEVGVISLGTTSQDGSQRQVKVEVLGVYDYAEKSIRLRAVEPITDGDRNYKKRFQAILEPLSRWVHKDSTICIDLTVDKITLFSMGFKNIVQAAATDNTAKHNNSAVMEYLRRIVPRMFQNTLSLLSRQMIQQFLDELVWRESFGTYALQAFNNIIIHIAEQTRVTTNETITQRLYQVATNPFKDWSILPANYKETPANAAPKRLKKPINDADYVVSNKIPKKEKDRDIASSGVKRGRPPNALGTPPPQLPIKKGPGRPPGSTNQTKGDRATTSSSKSLSKSLIAKGLGKKPKEKDEKIPMVIKKEEDDLRGLEELYYGISDGTDEYHEIFPYSTPRTVHNELAKTVECPICLNGDSFDSNEKLQTHLVSHISPEGKQHQFQCLFCLEKHPTESVLAKHNQIMHPTETKTEGSPSYYCLICQQRHNSLHLLTAHLQKVHSTLELPYWCHSCGYRSSSHRDLVRHFYDDHKHQNFLQCPYCLDIFYFSKLGVVNQLRIEHYFMHLDEHINKRDPSLRCQKCSLSFLEKGDLKQHAVQHHVSMTKTNRPVRLLLNNSMLIPPPKIRTHHREQPPFSTYKRPVFFAFLEGKTCAECNTDFASEETHYTGWLHCVKCNYQTCCERAQFRHGVECNGNFVDAMEVNMPQEMHCICGFATGNGNKMAQHLANCGLSTCYPSLEAASENAVKRNMLDMLGLVRRDGETSGEGADISETADDVADQSSDMLPPQEDHHLQQHHQQVGHQQQMQGQPNEPQAELQQEYLSAPVEHEPVQNMPVHQSMPVQQTGPIQFGEMEAAPVLLDTQQQVQPTPDYAQVSVVQQHQQQQPYGLSNYGQSSLATDIDMPLIGELSEPNAPPTPQFLGEVHTPMFDAVAAAEQQHYHAQHHHHPQXYKPHGKLKSRDYTLHWQNY
Protein: Root meristem growth factor 10 (AtRGF10) (CLAVATA3/ESR (CLE)-related protein CLELn) (AtCLELn) (Nuclear CLE-Like protein) [Cleaved into: CLELn] (F4JBX1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT), mainly at the post-transcriptional level (By similarity). Promotes root elongation.
Subcellular location: [CLELn]: Secreted {ECO:0000250|UniProtKB:Q3E880}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:22815541}.
Interaction partners:
- Protein GOLVEN 10
- Protein GOLVEN 6
- Protein GOLVEN 7
- Protein GOLVEN 5
- Protein PSY1
- CLAVATA3/ESR
- Protein-tyrosine sulfotransferase
Sequence:
MDMLRSACFYFLLIVFVILSWSLLCDSRHLGHMEKKLSVNLDLLNKDNEEITKLEAPSTNKTNTLLSQSHAVVNHGDNGQINGKKTKEIHRVKRASDKKVSSKRVSRTWKIPKYPKKQPKSDQEHPGFNLDYMQPTTHPPHHN
Protein: Putative ubiquitin-conjugating enzyme E2 N-like (Epididymis tissue protein Li 174) (Q5JXB2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAELPHRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGESKDSPFEGGTFKRELLLAEEYPMAAPKVRFMTKIYHPNVDKLERISLDILKDKWSPALQIRTVLLSIQALLNAPNPDDPLANDVVEQWKTNEAQAIETARAWTRLYAMNSI
Protein: Phototropic-responsive NPH3 family protein NPY3 (MAB4/ENP/NPY1-like proten 1) (MAB4/ENP/NPY1-like proten 2) (Protein NAKED PINS IN YUC MUTANTS 3) (Q9FN09)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May play an essential role in auxin-mediated organogenesis and in root gravitropic responses.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21490067}. Cytoplasm, cytosol {ECO:0000269|PubMed:21490067}. Note=Polar localization at the cell periphery almost identical to PIN proteins polarity, in the upper side of the plasma membrane towards the tips of cotyledon primordia in the protodermal cells and in root epidermis, and in the basal side of provascular cells, root stele, pericycle, endodermis and cortex, and in radicle tip cells (PubMed:21490067). Weakly observed in the cytosol of root tip quiescent center (QC) and columella cells, sometimes close to the basal side of the plasma membrane (PubMed:21490067). {ECO:0000269|PubMed:21490067}.
Interaction partners:
- Serine/threonine-protein kinase WAG2
- Probable indole-3-pyruvate monooxygenase YUCCA1
- Protein kinase PINOID 2
Sequence:
MKFMKLGSKPDSFQSDEDCVRYVATELATDVVVIVGDVKFHLHKFPLLSKSARLQKLIATTTTDEQSDDDEIRIPDIPGGPPAFEICAKFCYGMAVTLNAYNVVAVRCAAEYLEMYESIENGNLVYKMEVFLNSSVLRSWKDSIIVLQTTRSFYPWSEDVKLDVRCLESIALKAAMDPARVDWSYTYNRRKLLPPEMNNNSVPRDWWVEDLAELSIDLFKRVVSTIRRKGGVLPEVIGEALEVYAAKRIPGFMIQNDDNDDEEDVMEQRSLLETLVSMLPSEKQSVSCGFLIKLLKSSVSFECGEEERKELSRRIGEKLEEANVGDLLIRAPEGGETVYDIDIVETLIDEFVTQTEKRDELDCSDDINDSSKANVAKLIDGYLAEISRIETNLSTTKFITIAEKVSTFPRQSHDGVYRAIDMFLKQHPGITKSEKKSSSKLMDCRKLSPEACAHAVQNERLPLRVVVQILFFEQVRATTKPSLPPSGSHGSSRTTTEEECESVTATEETTTTTRDKTSSSEKTKAKGVVMSRIFSKLWTGKDKDGVGDVSSSDTSESPGSVTTVGDKSTPSTRRRRSSS