wanglab/gogpt-training-data huggingface dataset:
Protein: Rho guanine nucleotide exchange factor osg-1 (Oxidative stress-susceptible GEF1) (Q21653)
Organism: Caenorhabditis elegans
Function: Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress.
Interaction partners:
- Actin-related protein 2/3 complex subunit
- DH domain-containing protein
- Probable actin-related protein 2/3 complex subunit 3
Sequence:
MLNPNDADDSDSSTDSSPPVAVPRPKRSATVSPSTRNSFYNSRRRSDANLNFFNERERQRERRRSMVRASRERSESRRASQQNLRKTNSEPNVDMPSIDVEALQKLLLSIPKFVSASRNRINQRHDSDSGGEMTTEIEELKDAAKSIQSLQRVLAYPSQTSSDRGGNRRLADPVESCLESSVFSDVDESSLATDTIEGRRSGISTRLGHPRGVMQFIPSIRNDQFVPTSEIRRNSISRKSSVPDGFMTSEMESEPVPNVRNRRRGIVDEMFSSSTSLLVDRPSETLAGVNRFAKLLDTFRSRPTSPEQHPSISWNPYVYSDGGEALETCGMEDSLHEADILLWKKRSRASLRRHYSVRHLAARELLDTEKSFVEGLEFLVTKYMRPLRQPLECTLIEASLVDKIFYRIPEILAHHQVLLTTLSQRIDQWHKDAILGDVLLAHFSKQSMIETYISFVDNFKFAKASIIQARQKHAFEKYYNRCCRDHPNKLDLDSLLISPIQRVPRYELIVKQMLKHTPVEHEDRERLLRAQRHIHCLAVAINQHKDGSEQMEQRLREIEAIVDGLDDLVTKDRTLLRHDIITLKGTDRERCIFMLSDLLLVTSVKKKPKVLYSKMSSQSMGFLEGNRFKLLFKVALEDVQISKDTLSQLEEVERKLESSREDDRVLKKMSQLCSLLKCERKVLMEMLETMETSNSMSIRELNEQMSSDPDLSAVHLDVLTSNGFEPFVLEFPNAEKRSVFEAMFKDAKATLAKNLLAAPSCSLKTIIAHQTRPGLQLCTATVVPGKRVDSTPSLWVCASDKFSGQVAVMALDTGEITIESCSAIGNAAVTAMCTVPPPMKLRKRKIKSQKSLEHLLNETIMDINSSGSDTESSSDEGTSTAGQTTVWIGNDDGEVFVVNSTERVRSRARDRLARLRNSITSICAANGNVLVATSYSNQVQLLLFRPASDGSWDLENPQTVGHVCQAPITSMQLIGRRVIIASGNWLHAYFVDTGKFQPPVEILPSSDVITLMYVTGQNVFLCGRKSTEVFVVDVFNLSIINHFNVVSFVRSQLSGREHILREHKMGCLRISCLTVARSHLWIGTSAGCVLSTSVQSARSQPTPDLRVCEIGHSGPCRILLPVHTPSHSNHPSRKQKRSSLNVPAQQSSQLMLVSCGEGLDDGTATQDPSTDAINHLIFWKCS
Protein: NUP-1 protein (Q388V1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGEAMGMHNVAQPVQHEPIRTPSSSSPAKRLQSFSSGAVIYSPMVMQSTTHGTTATSASVGVSGEDASPISSYAAAEYEEIERKQYELRSAVEQRISTLEHALRQREEELEAVRMQLLKTEEDYKFNYNLIKDRDAALAEAATQVQSLYSELKRHRSDDALTTKRLEESEQQAQRLGQRLREVEEEKERALQQMQGAYELREKQLKEDIHNKGILMEKEKQRLHDEYLRRFKALDDARAELATKGQMLATEVEEGWRQQVNRLEAELRASVDAMDALQREKVENEGRLGETSRALSLLKQEHELLQHRFQSITASAADQKQKYEQKLAECRATMNHGITTAEDTVRQHVQRVSTLEAECGRLQRELTELQDRLQTTQFQRDEDTRHFINENRRAQEQYDQAAAQIEEQRRNMDETQRQFALRLQQLECDLGIALEAKKEAMCRVREYQDRCDGLQREHLQQHSEVERLRRELQQSREEEKITAARALEVQQLADEKTIAASRDVELAHAELQMQQRRMLDSQERAQAEVARLTRELHASEAARHAVEEQYRLVEDANGHRALIEALRCDKETLERKVLDLERANAAIREQVSSFAIELQNDPAVKTAKEMQHRVRELQEDLLRAREDNDQLRSTLREREEEVSRHRIEVLRLRSTGAVFLEQQNVGVRRHQTSEVACGCLSRGDSDRRKQQQPLCGNKKNRLPSDKPAAHEDDSSDRSSSSNRGRGAGFGGQRVVMGKRLAHKDGTLARKVESLRHRCLQLEQDARGLLRERDNLAKELELTRRDVDALTSEKQSLVDLNSLLKAQLREAYRTALECSQQCRRRQAVAGQPPDPRAEAVETVAVEPPNPGRLLTAGDMPNVAGAPRALSLDSERFAALEEELTAIKAHMLHKRSGCSRTSRHQAVSASPGNQKRLQGKPGKEESHCPGASAAPSSRSASQNKVTVVKRGSGAVRHYGYL
Protein: Putative uncharacterized protein encoded by LINC00588 (Q9Y4M8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATFHRAHATSSVKPRARRHQEPNSGDWPGSYRAGTRCSAIGFRLLHSPQHWRPRSLGAGQGREDPSWEGGALGDLKALWDQPCQPPPWVQLQLSSAYGARQQRWQLSTLPEPPAARTPGQMPQQRLIRAAGPSAAGGGNQWLSPM
Protein: U1 snRNP-associated protein usp108 (Q09848)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- U1 small nuclear ribonucleoprotein usp102
- Pre-mRNA-processing factor 39
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- U1 snRNP-associated protein usp109
- Pre-mRNA-processing protein prp40
- U1 snRNP-associated protein usp107
- U1 snRNP-associated protein usp106
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MDSGTSVVSISADILRPPVLTAAQTFGDNENECRVRLVLTAQQVQEWNLLPQDIQQEILKNGQVRVETYSSSNTARKIFICTSSVSNLASSIPALIKVVTPTKEEDASLNINLAVSSLILGSKVLIHQNLIPSLFSVSNSTKLLYSASLLPRSSERLVTLETNEIDASVVIETLLKYILSRISFIPRVSVVPYIPDAAYGIYGSPSTFTQFNHMSSMVTPENPYGIPPIALTSAGGNPDPLRTTQVFPHSGPSIPLNIAATQVVSQKMSVPSSLLDQLYHAMPHKLMEISQNTNANITVEESDSNSNEKFISVVGTSEANQSALMQLYAALISLGRK
Protein: Notchless homolog 1 (K7EN33)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
XSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKDDFHSVTWCSSGSSAAARSWLITTSASWVQVILLPQPPRYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR
Protein: Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (M32) (Modifier 2 protein) (P23198)
Organism: Mus musculus (Mouse)
Function: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:8751383}. Note=May be associated with microtubules and mitotic poles during mitosis (Potential). Associates with euchromatin and is largely excluded from constitutive heterochromatin. {ECO:0000305}.
Interaction partners:
- Histone-lysine N-methyltransferase SUV39H1
- Histone-lysine N-methyltransferase EHMT2
- Transcription factor E2F6
- Polycomb group RING finger protein 6
- Histone H3.3
- Histone H3.2
- Histone H3.1
- Lethal
- E3 ubiquitin-protein ligase RING1
- Transcription intermediary factor 1-beta
Sequence:
MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEDFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ
Protein: Starch synthase 1, chloroplastic/amyloplastic (AtSS1) (SSS) (EC 2.4.1.21) (Soluble starch synthase I) (Q9FNF2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the synthesis of short glycan chains within amylopectin in leaves. Is required to generate chains up to about a degree of polymerization of 10 (DP10).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:16045475}. Plastid, amyloplast {ECO:0000269|PubMed:16045475}.
Interaction partners:
- 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic
- 1,4-alpha-glucan-branching enzyme 2-2, chloroplastic/amyloplastic
- 4-alpha-glucanotransferase DPE2
- 1,4-alpha-glucan-branching enzyme 3, chloroplastic/amyloplastic
- 1,4-alpha-glucan-branching enzyme 2-1, chloroplastic/amyloplastic
- Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic
- Glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic
- Glucose-1-phosphate adenylyltransferase small subunit, chloroplastic
- Glucose-1-phosphate adenylyltransferase large subunit 3, chloroplastic
- Probable glucose-1-phosphate adenylyltransferase large subunit, chloroplastic
Sequence:
MASLQISGSVKFEPFVGFNRIRHFRPIASLGFPRFRRRFSIGRSLLLRRSSSFSGDSRESDEERFITDAERDGSGSVLGFQLTPPGDQQTVSTSTGEITHHEEKKEAIDQIVMADFGVPGNRAVEEGAAEVGIPSGKAEVVNNLVFVTSEAAPYSKTGGLGDVCGSLPIALAGRGHRVMVISPRYLNGTAADKNYARAKDLGIRVTVNCFGGSQEVSFYHEYRDGVDWVFVDHKSYHRPGNPYGDSKGAFGDNQFRFTLLCHAACEAPLVLPLGGFTYGEKSLFLVNDWHAGLVPILLAAKYRPYGVYKDARSILIIHNLAHQGVEPAATYTNLGLPSEWYGAVGWVFPTWARTHALDTGEAVNVLKGAIVTSDRIITVSQGYAWEITTVEGGYGLQDLLSSRKSVINGITNGINVDEWNPSTDEHIPFHYSADDVSEKIKCKMALQKELGLPIRPECPMIGFIGRLDYQKGIDLIQTAGPDLMVDDIQFVMLGSGDPKYESWMRSMEETYRDKFRGWVGFNVPISHRITAGCDILLMPSRFEPCGLNQLYAMRYGTIPVVHGTGGLRDTVENFNPYAEGGAGTGTGWVFTPLSKDSMVSALRLAAATYREYKQSWEGLMRRGMTRNYSWENAAVQYEQVFQWVFMDPPYVS
Protein: Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) (Q8CHC4)
Organism: Mus musculus (Mouse)
Function: Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (By similarity). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O18964}.
Interaction partners:
- Endophilin-A1
- Epidermal growth factor receptor substrate 15
- Amphiphysin
- Myc box-dependent-interacting protein 1
- AP-2 complex subunit alpha-1
- Endophilin-A2
- Endophilin-A3
- Epidermal growth factor receptor substrate 15-like 1
- Clathrin heavy chain 1
- SH3-containing GRB2-like protein 3-interacting protein 1
Sequence:
MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYAKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRVDASDEDRISEVRKVLNSGNFYFAWSASGVSLDLSLNAHRSMQEHTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVIYLDDCVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKDLYGKQIVVNLLGSKEGEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGKAEKLHSILKPQVQKFLDYGFFYFDGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKNMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVNASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFVEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSEDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQKIYKEVIAVQGPPDGTVLVSIKSSAQESTFFDDALIDELLRQFAHFGEVILIRFVEDKMWVTFLEGSSALNALSLNGKELLNRTITITLKSPDWIKHLEEEMSLEKISVTLPSSASSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTVPEYSAPSLPIRPSRAPSRTPGPPSSQGSPVDTQPAAQKDSSQTLEPKRPPPPRPVAPPARPAPPQRPPPPSGARSPAPARKEFGGVGAPPSPGVARREIEAPKSPGTARKDNIGRNQPSPQAGLAGPGPAGYGAARPTIPARAGVISAPQSQARVCAGRPTPDSQSKPSETLKGPAVLPEPLKPQAAFPQQPSLPTPAQKLQDPLVPIAAPTMPPSGPQPNLETPPQPPPRSRSSQSLPSDSSPQLQQEQPTGQVKINGISGVKQEPTLKSDPFEDLSLSVLAVSKAQPSVQISPVLTPDPKMLIQLPSASQSQVNPLSSVSCMPTRPPGPEESKSQESMGSSANPFPSLPCRNPFTDRTAAPGNPFRVQSQESEATSWLSKEEPVPNSPFPPLMPLSHDTSKASSSLGGFEDNFDLQSQSTVKTSNPKGWVTFDEDDNFPTTGKSKSVCPDLVGNAPASFDDDWSKGASVSFCVLPARRPPPPPPPVPLLPPGTTSSAGPSTTLPSKAPSTLDFTER
Protein: PARP-type zinc finger-containing protein C13F5.07c (O13706)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00264, ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MEQGGSGYRIEIAPNNRAKCKGSLCGRSKILAGTVRFGTFVDSGRFQSWAWKHWGCVTPRMLKNIKNRLGEDDIVNSLDGITALSQEWIDKVVDAINEGHVSESDERESRKLGEKMNVNSQKLKTSSPPKVVRKNKRHHTTVKSVLSDSDLDAEFTDGSEAYEDD
Protein: CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) (Q9ESJ1)
Organism: Mus musculus (Mouse)
Function: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).
Subcellular location: Nucleus. Cytoplasm. Cell projection, growth cone. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons.
Interaction partners:
- Cyclin-dependent kinase 5
- Tyrosine-protein kinase ABL1
- Wee1-like protein kinase
- Cyclin-dependent kinase 2
- Cellular tumor antigen p53
Sequence:
MAAATATAGTAACSSSSSSRGGSTDAAATSGVQPPPPPPATAPPEPLRKPRMDPRRRQAALSFLTNISLDGRPPLQDHEWGGGEEGGGTKPGARARLSLLAAGCNAFSAPGTAAAPWTAGSGSSPCPLPPSLVPRVLGEPSQPPRSAPAVTGAQLQLPDGPGGAGQEELEEDDAFTNVQVPSASFLGSGTPGSTSGSRGRLNSFTQGILPIAFSRQNSQNYCALEQSGQGGSTSALEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTKNGRDLKLDGGRQSAGAMSLKEIIGLEGVELGADGKTVSYTQFLLPTNAFGNRRNTIDSTASFSQFRSLSHRSLSMGRAGSTQGSLDAGSDLGDFMDYDPNLLDDPQWPCGKHKRVLTFPSYMTTVIDYVKPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREMRKLAQEDCGFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHEVKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLIQSS
Protein: Spermatogenesis-associated protein 24 (TATA-binding protein-like factor-interacting protein) (TLF-interacting protein) (TRF2-interacting protein in testis) (Testis protein T6441 homolog) (Q6P926)
Organism: Mus musculus (Mouse)
Function: Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis.
Subcellular location: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Associated with chromatin.
Interaction partners:
Sequence:
MATPLGWSQGGSGSVCLAFDQLRDVIESQEELIHQLRNVMVLQDENFVSKEEFHEIEKKLVEEKAAHAKTKALLAKEEEKLQFALGEVEVLSKQLEKEKMAFEKALSSVKSRVLQESSKKDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQNFRNHISDFRIQKQQETYMAQVLDQKRKKATGMRRARSRQCSREK
Protein: Uncharacterized protein (Q386D2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPCNEQTSHKPKPNQLVDGGQMKVLSAGEQVLVLRHLSRTYRLGVALVRVLAALQLLLAFLYICLIIVGYPLVVVDLNDNMSNTSASPTKPGALSRGGTAAITISAVLLAVAGLSDIRSCRGVLYVHPSLPDIGSHTNNFPRTTQTRHVEGNTDSFSDISPRYQFVIALLSLLPTTYWLFTMVSYRWHLAQKGALLFGFVENWRELLIVIWQPVGHTIFGMLLASMVSAKEDLIGLAHMKYE
Protein: BAHD acyltransferase BIA1 (EC 2.3.1.-) (Protein ABNORMAL SHOOT 1) (Protein BRASSINOSTEROID INACTIVATOR 1) (O23393)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Monitors brassinosteroids (BR) responses and homeostasis, particularly in the root and hypocotyl in darkness. Promotes flavonoid biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22544867, ECO:0000269|PubMed:22956280}.
Interaction partners:
- BAHD acyltransferase DCR
- Cytosolic sulfotransferase 10
- Uncharacterized protein AT3g24100
- Cytochrome P450 72C1
- UDP-glycosyltransferase 73C5
- UDP-glycosyltransferase 73C6
- B3 domain-containing protein At2g36080
- Steroid
- 3-epi-6-deoxocathasterone 23-monooxygenase CYP90C1
- Spermidine coumaroyl-CoA acyltransferase
Sequence:
MEAKLEVTGKEVIKPASPSPRDRLQLSILDLYCPGIYVSTIFFYDLITESSEVFSENLKLSLSETLSRFYPLAGRIEGLSISCNDEGAVFTEARTDLLLPDFLRNLNTDSLSGFLPTLAAGESPAAWPLLSVKVTFFGSGSGVAVSVSVSHKICDIASLVTFVKDWATTTAKGKSNSTIEFAETTIYPPPPSHMYEQFPSTDSDSNITSKYVLKRFVFEPSKIAELKHKAASESVPVPTRVEAIMSLIWRCARNSSRSNLLIPRQAVMWQAMDIRLRIPSSVAPKDVIGNLQSGFSLKKDAESEFEIPEIVATFRKNKERVNEMIKESLQGNTIGQSLLSLMAETVSESTEIDRYIMSSWCRKPFYEVDFGSGSPVWVGYASHTIYDNMVGVVLIDSKEGDGVEAWISLPEEDMSVFVDDQELLAYAVLNPPVVA
Protein: Protein Tob2 (Transducer of erbB-2 2) (Q9JM55)
Organism: Mus musculus (Mouse)
Function: Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
Interaction partners:
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 8
Sequence:
MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLRKKYEGHWYPEKPLKGSGFRCVHIGEVVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQIGEKGVVKVLYLGDSEASGTPELDKEIKSSFNPDAQVFVPIGSQDSSLSSSPSPSFGQSPSPTFIPRSAQPITFTTASFAATKFGSTKMKKGGGASGGVSVGGSGAGGQQPPPQQPRMARSPTKNLLKHKSLSLSMHSLNLIPANPAPQSQLSPNAKEFVYNGGGSPSLFFDGVEGPSTSTTAPFGSGGASTCNSSSFDVSQVFGGGANSLFLEKSPFVEGLSYNLNTMQYPNQPFQPVVLAN
Protein: Stevor (Q8IM81)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MNIYHVKMLIFMFLINALVLPHYENCQNDHYNKSLLQKNTQRTTIKSRLLAQTQNHNPHYHNDPELKEMIDKMNEEAIKKYQKTHDPYKQLKEVVEKNVTKHVSGHVAEPMSTTEKDLLETYEEMFGHKNDIMLKSGMYPNDDNGSDKSSTCEYTDTNNTKLEKTKGKDKYLKHLKHRCIGGICSCSVGSFLLTMSGLYFAKAAVLKYIASVGPPYNACASTINIYNMIAGGSACVSDITGTAASAATAIFEPCGIAALVLLILAVVLIILYIWLYRRRKNSWKHECKKHLCK
Protein: Proteinase-activated receptor 3 (PAR-3) (Coagulation factor II receptor-like 2) (Thrombin receptor-like 2) (O08675)
Organism: Mus musculus (Mouse)
Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Prothrombin
- Proteinase-activated receptor 4
Sequence:
MKILILVAAGLLFLPVTVCQSGINVSDNSAKPTLTIKSFNGGPQNTFEEFPLSDIEGWTGATTTIKAECPEDSISTLHVNNATIGYLRSSLSTQVIPAIYILLFVVGVPANIVTLWKLSLRTKSISLVIFHTNLAIADLLFCVTLPFKIAYHLNGNNWVFGEVTCRITTVVFYGNMYCAILILTCMGINRYLATAHPFTYQKLPKRSFSMLMCGMVWVMVFLYMLPFVILKQEYHLVHSEITTCHDVVDACESPSSFRFYYFVSLAFFGFLIPFVIIIFCYTTLIHKLKSKDRIWLGYIKAVLLILVIFTICFAPTNIILVIHHANYYYHNTDSLYFMYLIALCLGSLNSCLDPFLYFVMSKVVDQLNP
Protein: Lipoprotein (E0SE52)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004459}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004459}.
Interaction partners:
- Type III secretion inner membrane protein
- Type III secretion inner membrane protein
- Type III secretion inner membrane channel protein
- Type III secretion inner membrane protein
- Type III secretion protein
- Type 3 secretion system secretin
- Type 3 secretion system ATPase
- Type III secretion inner membrane protein
- HrpE
- HrpD
Sequence:
MELHRGLSENDANEVIAALGGYHIGAEKRTEKTGVSILIDVKDMERAVNILNAAGLPRQARTNLGQVFQKTGVISTPLEERARYIYALSQEVESTLTQIDGVLVARVHVVLPERIAPGEPIQPASAAVFIKYRPELEPDSIEPRIRRMVASSIPGLAGKSDKDLAIVFVPAEPYKDHIPTVSLGPFQLTPQTMTQLQWLAGLLALALAGVLGWRFGKPWWEQQRARRKPAQPDAGA
Protein: Neutrophil cytosol factor 1 (SH3 and PX domain-containing protein 2A) (B5X4S7)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- NADPH oxidase cytosolic protein
- Neutrophil cytosol factor 4-like
- Cytochrome b-245 light chain
- Cytochrome b-245 light chain
- Neutrophil cytosol factor 2
- NADPH oxidase activator 1
- SH3 and PX domain-containing protein 2B isoform X3
- Ras-related C3 botulinum toxin substrate 2
- Ras-related C3 botulinum toxin substrate 2
- Ras-related C3 botulinum toxin substrate 2-like
Sequence:
MEETYVRHVEFLGFEKRFFPSQHYVYMLMVKWNNLSEKLIYRGYPEIYTFHKSLMEMFPIEAGDIDKKDRIIPALPAPKWLDSQKSTETRQSTLAEYCHSLINLPPKISHCQLVCNFFKVRPEDENPPAQQPFKRNDNIVMSTDKARGNTSEISGPIILESYRVIADYSKTSKYEINLLTGDFVEIVEKSPNGWWFCQCDTKRGWVPASYLEPLDGPEEPEEADPNYAGEVYITTKEYKAAQDDELTLETGETIEVIHKLLDGWWVVRKGEETGHFPSMFLHKTGEKKEMESEENVTRRQTPPPRRSTIRNAQSIHGKGRKGISQNTYRRNSRRFLLQKGDWPNQPRKTSNDAPQSPLQERKNGDNIPKPAGSSPGGELKKGAPLIPPRPSPELIMERCTENTCKKVSVRKSN
Protein: Magnesium transporter MRS2, mitochondrial (RNA-splicing protein MRS2) (Q01926)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14562095, ECO:0000305|PubMed:23999289}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Magnesium transporter ALR1
- Mitochondrial RNA-splicing protein MRS3
- Manganese resistance protein MNR2
- Mitochondrial RNA-splicing protein MRS4
- Magnesium transporter ALR2
- Mitochondrial distribution and morphology protein 38
- mRNA-binding protein PUF3
- Rab proteins geranylgeranyltransferase component A
Sequence:
MNRRLLVRSISCFQPLSRITFGRPNTPFLRKYADTSTAANTNSTILRKQLLSLKPISASDSLFISCTVFNSKGNIISMSEKFPKWSFLTEHSLFPRDLRKIDNSSIDIIPTIMCKPNCIVINLLHIKALIERDKVYVFDTTNPSAAAKLSVLMYDLESKLSSTKNNSQFYEHRALESIFINVMSALETDFKLHSQICIQILNDLENEVNRLKLRHLLIKSKDLTLFYQKTLLIRDLLDELLENDDDLANMYLTVKKSPKDNFSDLEMLIETYYTQCDEYVQQSESLIQDIKSTEEIVNIILDANRNSLMLLELKVTIYTLGFTVASVLPAFYGMNLKNFIEESEWGFTSVAVFSIVSALYITKKNFNSLRSVTKMTMYPNSPANSSVYPKTSASIALTNKLKRRRKWWKSTKQRLGVLLYGSSYTNKANLSNNKINKGFSKVKKFNMENDIKNKQNRDMIWKWLIEDKKN
Protein: STAG1 cohesin complex component (C9JJQ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIRGAGRGRANGHPQQNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMPGPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAGQVLGTR
Protein: Alkaline nuclease (EC 3.1.-.-) (F5HF49)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.
Subcellular location: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04009}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04009}.
Interaction partners:
Sequence:
MWGVSSLDYDDDEELTRLLAVWDDEPLSLFLMNTFLLHQEGFRNLPFTVLRLSYAYRIFAKMLRAHGTPVAEDFMTRVAALARDEGLRDILGQRHAAEASRAEIAEALERVAERCDDRHGGSDDYVWLSRLLDLAPNYRQVELFQLLEKESRGQSRNSVWHLLRMDTVSATKFYEAFVSGCLPGAAAADGSGGGGSHYTGSRAGVSPGIQFGIKHEGLVKTLVECYVMHGREPVRDGLGLLIDPTSGLLGASMDLCFGVLKQGSGRTLLVEPCARVYEIKCRYKYLRKKEDPFVQNVLRRHDAAAVASLLQSHPVPGVEFRGERETPSAREFLLSHDAALFRATLKRARPLKPPEPLREYLADLLYLNKAECSEVIVFDAKHLNDDNSDGDATITINASLGLAAGDAAGGGADHHLRGSPGDSPPPIPFEDENTPELLGRLNVYEVARFSLPAFVNPRHQYYFQMLIQQYVLSQYYIKKHPDPERIDFRDLPTVYLVSAIFREREESELGCELLAGGRVFHCDHIPLLLIVTPVVFDPQFTRHAVSTVLDRWSRDLSRKTNLPIWVPNSANEYVVSSVPRPVSP
Protein: Otolith matrix protein 1 (OMP-1) (Q0VIL3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for normal otolith growth and deposition of otolin-1 in the otolith.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9IBF7}.
Interaction partners:
- Otoconin 90.
- Protein starmaker
- Zona pellucida-like domain-containing 1a.
- Otolin-1-A
- Otolin 1b
- Otopetrin 1.
- SPARC-like 2
- Beta tectorin
Sequence:
MDLPGGHLAVVLFLFVLVSMSTENNIIRWCTVSDAEDQKCLDLAGNATARNLRGQLVCVRGQSPTDCMKQIKNGTADASTMYADEIYTAGFCYGLDVAVGESYNGVDGINYYVVALARTSSSDLSLLEMHERSSCHPGMRTTVGWTVPIGFLVNTSQISVDVQCNFPHAVGDFFGYSCVPGVKDPEHDPKGNNPRNLCEACIGDENDRHICANNPRERHFGEAGALRCVAENLGDVAFVKHTTVFDNMQGKNQESWALDLELEDLKLLCPDGSEANLFQHESCHLAVVPTNAVVVRLEDKCRVYKFLERVQNAFGNTTEGFSLFSSVNYGQPDVLFSDSTKKLLRVMGTYTSWLGPSYTTILRAFECEGLC
Protein: Complex I intermediate-associated protein 30, mitochondrial (O42636)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:9769214}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- DUF498 domain-containing protein
- NADH dehydrogenase 1 alpha subcomplex subunit
- NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial
- NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial
- Acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase
- Complex I intermediate-associated protein 84
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 1
Sequence:
MRATQSLPFKSFWSRSLDELSRLTNIVVKSENIRGATGPREIHNFQTPESVADCKLLSDADVGGSSTAHLDWVPPPNAIPTVTAGDGSDRKPYTPIPGSYARFHGTISLELPTDRREISRTGYAGFRTLDRPPTIFGRGLWDIDPYAYLAMRVKTDARSYFVNVRTESVVPLDLHQHRLFVKKPGQWETVLIKWNDFVRTNHGKVIEPQTGMLRQKVLSIGFSTTDRKAGPYELCVERLWATNDFDEAGVVETDVAGAQLKNKHGEKVKVTWGALEQE