Protein: Transformation/transcription domain-associated protein (A0A0R4ITC5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression (By similarity). May play a role in the formation and maintenance of the auditory system.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y4A5}.
Interaction partners:
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 10
- SAGA-associated factor 29
- Transcription initiation factor TFIID subunit 12
- SPT3 homolog, SAGA and STAGA complex component
- SPT20 homolog, SAGA complex component.
- Transcriptional adapter 3
- RuvB-like 1
- Ubiquitin carboxyl-terminal hydrolase 22
- DNA methyltransferase 1-associated protein 1.
Sequence:
MSFVPTPSPTVVDQTTLMKKYLQFVAALTDNNTPDETKLKMMQEVSENFENVTSSPQYSTFLEHIIPRFLTFLQDGEVQFLQEKPTQQLRKLVLEIIHRIPTNEHLRSHAKNILSVMFRFLEIESEENVLICLRIIIELHKQFRPPISQEIHHFLDFVKQIYKELPKVVARYFENPQVIAENTVPSPEMVGMITSVMVKTAPERDDSETRTHTIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVSEFVPLIMNTIMLQVSPQARQHKLFNKELYADFIAAQIKTLSFLAYIIRIYQDLVGKYSQQMVKGMLQLLSNCPPETAHLRKELLIAAKHILTTDLRSQFIPCMDKLFDESILIGSGYTARETLRPLAYSTLADLVHHVRQNLPLTDLSLAVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIRSKSEQENGNGRDILMRMLEVFVLKFHTIARYQLVSIFKKCKPQSEMGVVDTGALPGVPATPTVTTPALPPPAPPTPVTPAPPPATSFDRAGEKEDKQTFQVSDCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQALDIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVERISKNYALQIVANSFLANLTTSALFATILVEYLLERLPEMGSNVELSNLYLKLFKLVFGSVSLFAAENEQMLKPHLHKIVNSSMELAQSAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPAETISHVAYRVLGKFGGSNRKMLKESQKLLYVVTEVQGPSIKAEFTDCKASIQLPMEKAIETALDCLKSANTEPYYRRQAWEVIKCFLVAMTSLEDNKHSLYQLLAHPNFTEKWIPNVIISHRYKAQDTPARRTFEQALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQSGSQPSTGMFHSEENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSYIVERLCACCYEQAWYAKLGGVVSIKFLMERLPLIWVLQNQLTFLKALLFVMMDLTGEVSNGAVAMAKTTLEQLLIRCATPLKDEEKTEELLSAQDKSFHLVTHDLVREVTSPNSTVRKQAMHSLQVLAQVTGKSVTIIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQPRLFTMDLNVMEHKVFYTELLNLCEAEDAALMKLPCYKSLPSLVPLRIAALNALAACNYLPQSREKIIAALFKALNSTNSELQEAGEACMGKFLEGATIEVDQIHTHMRPLLMMLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQRGDGSPAMEGVEEMRICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDAKPLRDVLASNPNRFVPLLVPAGSAATVRPGSPSTSTARLDLQFQAIKIISIIVKNDEGWLAGQHSLVSQLRRVWVSEAFQERHRKDNMAATNWKEPKLLAFCLLSYCKRNYSEIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPKNYGITHKRALFFRFVEFNDPHFNDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPEGDNPESITSVFITKVLDPEKQADLADSLRIYLLQFSTLLVEHAPHHIHDNNKSRNSKLRRLMTFAWPCLLPKTCVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHTMEARAIVRQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFRVYYPVRHHLVQHMISAMQRLGFTPSVTIEQRKLAVDLAEVVIKWELQRIKDQQPESEADPGSVGEGTSGASAAMKRGMSVDSAQDVKRFRTAAGAVGTVFGRSQSIPGTEALLTKPVEKQHTDTVVNFLIRIACQVNDSTNVAGSPGELLSRRCVNLMKTALRPDMWPSSELKLQWFDKLLMTVEQPNQANFSNICTGLEILCFLLSVLQPPAILSHFKPLQRGIAACMTCGNTKVLRAVHSLLSRLMSTFPTEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKASSANPTQLFGTLMILKSACSNNSSYIDRLISVFMRSLQKMVREHLSPQPNPGAAETSTVTSELVMLSLDLVKMRLSVMNMEMRKNFIQVILTSLIEKSPDPKILRAVVKIVEEWVKNSGNPMATNQVPNPREKSILLVKMMTYIEKRFPDDLELNAQFLDLVNYVYRDDNLSGSDITSKLEPAFLSGLRCTQPLIRAKFFEVFDASMKRRVYERLLYICCSQNWESMGSHFWIKQCTELLLAVCERNTTIGTSCQGSMLPSITNVINLADSHDRAAFAMATHIKQEPRERENSETKEEDVEIDIELAPGDQTSLPKTKEQAERDAGNQLHMLTNRHDKFLDSLREVKTGALLNALVQLCHISTPLAEKTWVQLFPRLWKILSDRQQHALSGEMGPFLCSGSHQAQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTHNLWLRSTLMLEQQAFEKGLNLHIKPKQSTEFYEQESITPPQQEILDSLAELYSLLQEEDMWAGLWQKRCKFPETSTAIAYEQHGFFEQAQETYEKAMEKARKEHNVSPAIFPEYQLWEDHWIRCSKELNQWEPLTEYGQSKGHNNPYLVLECAWRVSNWAAMKEALVQVELSCPKEMAWKVNMHRGYLAICHPEEQQLNFIERLVEMASSLAIREWRRLPHIVSHVHTPLLQAAQQIIELQEAAQINAGLQPANLGRNTSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQHHYQAIVTAYENNTQHDPNTNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYLENIFVKDRQPHLGVSSITCYLHACRHQNESKSRKYLAKVLWLLSFDDKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKPLLNLISQVGRVYPQAVYFPIRTLYLTLKIEQRERYKSDSGQQQPSSAAAQTHSASDPGPIRATAPMWRCSRIMHMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARRAQATAQDPVFQKMKGQFTTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQGNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGLAEFMLHLNRLNPEMLQIAQDTGKLNVSYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKAVLRDEIIAWHKKTQEDTSMPLSPAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAANSLDNLCRMDPAWHPWL