wanglab/gogpt-training-data huggingface dataset:
Protein: G-protein alpha subunit activating protein gbas-1 (Q9TZI4)
Organism: Caenorhabditis elegans
Function: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates G-protein alpha subunit goa-1.
Interaction partners:
- NUCleoBindin homolog
- Malignant brain tumor repeat protein 1
- Tetratricopeptide repeat protein 28
- Guanine nucleotide-binding protein G
Sequence:
MRSVRSSSRTPKPVKRFVFDEDEDLEEIDLDEVDNADFEREDDEEEVLSEPSESPYTSTPKSSKRVNKTRGTKDFFKKDESLQLFRFVLNECRSQKPGRVGRVAKKRVGVNSMKYWERYKREIQGYRLPKQYRYHYSFYSKCFYKVLGLTPEEKVDLYYACEMPVVTDAEKQWLVEQFHVEFDEFGVIIGSDVCTHWDEEHSDSEDDSGKKEEKAREVSRYTEYHDDMMWKFIVDKISEGAQPIIDKHPIWDEFVKLNEENDVISKKSGRNHYDRFRRILVPNLHFMPYDDFTKAVLYERLEYPIPEEYRKILFTTTGADINESGFIEYLPPSTIHQISPIVPIPCHKSNPKFSQLKEPKDLILWSERKKFTPREDSQIWEFVRRKCVDSAGIFVKNDVLRGRGTLFFKDFRNTERKYESITQRFVVLRKLIMDTDYSLKQKLEIYYAISQPVDEDALDAFKSIACLVLNPDGTIRFAISKSFLIGRISDEPAKLEAENYSYVYDLFIFNETFGTAENPEPLCSVSQNRAEKFMLVSQLVFRFISRFEALEDRRIAWITPNAQVAPKEPVPAPSKKKSAFEAYQSSPQTFDTIQRFSTKRPFFCGDNFQIPPKKPFLAEEDVKLEPMEYENSEQIVENAEIKLEPAEELLDAETVTVEEFLMNSYSTAAPSTSTAPAPPKAPVTAPPAPQKSAQLLGKIDFAIGKMRENFDRFLQFAQQNSADLTVVQRYRYDAQMQQMTEKFTKDVSKVLSGDSIKR
Protein: Kelch repeat and BTB domain-containing protein 6 (Q86V97)
Organism: Homo sapiens (Human)
Function: As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25684205}. Nucleus {ECO:0000269|PubMed:25684205}.
Interaction partners:
- Kelch repeat and BTB domain-containing protein 7
- Cullin-3
- E3 ubiquitin-protein ligase RBX1
- Kelch repeat and BTB domain-containing protein 8
- Kelch-like protein 42
- Kelch-like protein 9
- BTB/POZ domain-containing protein KCTD17
- Kelch-like protein 8
- Speckle-type POZ protein-like
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Sequence:
MQSREDAPRSRRLASPRGGKRPKKIHKPTVSAFFTGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSKRMFCYDPSHNMWLKCVSLKRNDFQEACVFNEEIYCICDIPVMKVYNPVRAEWRQMNNIPLVSETNNYRIIKHGQKLLLITSRTPQWKKNRVTVYEYDIRGDQWINIGTTLGLLQFDSNFFCLSARVYPSCLEPGQSFLTEEEEIPSESSTEWDLGGFSEPDSESGSSSSLSDDDFWVRVAPQ
Protein: GATA transcription factor 23 (Q8LC59)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Auxin-responsive protein IAA28
- Probable membrane-associated kinase regulator 4
- LOB domain-containing protein 33
- LOB domain-containing protein 29
- LOB domain-containing protein 16
- Auxin response factor 19
- Auxin-responsive protein IAA14
- Auxin response factor 7
- Protein RALF-like 34
- At4g16100)
Sequence:
MDPRKLLSCSSSYVSVRMKEEKGTIRCCSECKTTKTPMWRGGPTGPKSLCNACGIRHRKQRRSELLGIHIIRSHKSLASKKINLLSSSHGGVAVKKRRSLKEEEQAALCLLLLSCSSVLA
Protein: Myelin-associated oligodendrocyte basic protein (Q63327)
Organism: Rattus norvegicus (Rat)
Function: May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10537049, ECO:0000269|PubMed:8551331}. Note=Present in the major dense line of CNS myelin. Isoform 5 may be differentially localized in the oligodendrocytes or perinuclear region. Isoform 2, 4, 5 and 6 are highly enriched in myelin. Isoform 1 and 3 are not enriched in mylein.
Interaction partners:
- Myelin-oligodendrocyte glycoprotein
- Myelin proteolipid protein
- Ermin
- Myelin basic protein
- Myelin-associated glycoprotein
- Opalin
- NK6 homeobox 2
- 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Sequence:
MSQKVAKEGPRLSKNQKFSEHFSIHCCPPFTFLNSKREIVDRKYSICKSGCFYQKKEEDWICCACQKTSRRATSPQKPKHQPAASPVVVRAPPAKPKSPPRPAKPRSPPIPAKPRSPSRTERQPRPRPEVRPPPAKQKPPQKSKQPARSSPLRGPGTSRGGSPTRAPRFW
Protein: Derlin-3 (Degradation in endoplasmic reticulum protein 3) (DERtrin-3) (Der1-like protein 3) (Q96Q80)
Organism: Homo sapiens (Human)
Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:16449189}.
Interaction partners:
- Protein OS-9
- Protein sel-1 homolog 1
- E3 ubiquitin-protein ligase synoviolin
- Derlin-1
- Endoplasmic reticulum lectin 1
- Derlin-2
- ER degradation-enhancing alpha-mannosidase-like protein 1
- Ubiquitin recognition factor in ER-associated degradation protein 1
- Transitional endoplasmic reticulum ATPase
- E3 ubiquitin-protein ligase AMFR
Sequence:
MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTNFLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGHIYYFLEDVFPNQPGGKRLLQTPGFLKLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ
Protein: RPL36A-HNRNPH2 readthrough (H7BZ11)
Organism: Homo sapiens (Human)
Interaction partners:
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein eL43
Sequence:
MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKLHQNCIEPNLPPRAQQSP
Protein: Nuclease 1, mitochondrial (EC 3.1.30.-) (SpNUC1) (Q10480)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: This enzyme has both RNase and DNase activity. It degrades single-stranded DNA and RNA.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11406279}.
Interaction partners:
- Ribonuclease Z 1
- Ribonuclease Z 2, mitochondrial
- NADH-ubiquinone oxidoreductase 51 kDa subunit homolog SPBC18E5.10, mitochondrial
Sequence:
MSSNLIKSFGLIAIGAISGVTFTHFYYKGYQGSDVPDLTPRYTKFDSAGRALESIYDFNATKFFQYGIPGPVADQRVNHGYMSVFDRRTRNPFYTAETITQESLNQRKGNRRYSEFVPDDNIPEMFQAKLGDYRGSGYDRGHQVPAADCKFSQEAMNETFYLSNMCPQVGDGFNRNYWAYFEDWCRRLTSKYGSVTIMTGPLYLPKKNERGQWEVQYRVIGNPPNVAVPTHFFKVIIAEKSGEPTSSPSVAAFVLPNKPIADNFPLKNFAVPVEVVERASGLEILSNVPKGNRKQLCSEVVCQLNVKEFVESVKQKQKNQGK
Protein: Plasmodesmata-located protein 4 (PD-located protein 4) (Cysteine-rich repeat secretory protein 39) (Q6E263)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates cell-to-cell trafficking.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8GXV7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8GXV7}. Cell junction, plasmodesma {ECO:0000269|PubMed:20886105}. Note=Co-localizes with the Grapevine fanleaf virus (GFLV) 2B-MP at the base of tubules within modified plasmodesmata. {ECO:0000269|PubMed:20886105}.
Interaction partners:
- Protein At-4/1
Sequence:
MVVHLISLLTQTLALIILSLPSIINTSQLDYDTLVFKQCDPLDANILQKATTKSPNYSNQNLFLRAQALSSFLRKLESESSRSKFLKTLVGNEKHAVSGWFQCREDYPSEICHKCVGDLREISSRSCGNATSARIHLRGCHLIYKFERIDTPGAQVNNHHKYKLFETPEHGLIHKICDGATAETFPGFEEMRTEALTAAETGVVDGHGFYEDSYKLLHVVAQCDGHVEACDCGECISSAAAAAAEECRWSIAGQIYLEGCHVGYTYHPHELPNDSYHEEGSKVNTGKSLAIVVGGVAALVFVAIFFMFLKSLRKKGDDC
Protein: AHNAK nucleoprotein (A0A494BBD5)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEKEEETTRELLLPNWQGSGSHGLTIAQRDDGVFVQEVMQNSPAARTGVVKEGDQIVGATIYFDNLQSGEVTQLLNTMGHHTVGLKLHRKGDRSPEPGQTWTHEVFSSRSSEVVLSGDDEDYQRIYTTKIKPRLRSEDGVEGDLGETQSRTITVTRRVTAYTVDVTGREGVKDIDITSPEFMIKIPRHEVTEISNTDVETQPGKTVIRLPSGSGPASPTTGSAVDIRAGAISASGPELEGAGHSKFQVTVPGAKVGSLDVNVKAKGLDLGGKGGIRVPGVDVSSSLGAGSVEVQAPSLQSGDIGKIKIPTM
Protein: ESAT-6-like protein EsxN (P9WNJ3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Secreted {ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462}. Note=Secreted via the ESX-5 / type VII secretion system (T7SS). {ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462}.
Interaction partners:
- ESAT-6-like protein EsxK
- ESAT-6-like protein EsxP
- ESAT-6-like protein EsxJ
- 6 kDa early secretory antigenic target
- ESAT-6-like protein EsxB
- ESAT-6-like protein EsxO
- ESAT-6-like protein EsxL
- ESAT-6-like protein EsxW
- PPE family protein PPE18
- ESAT-6-like protein EsxI
Sequence:
MTINYQFGDVDAHGAMIRAQAASLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA
Protein: Acetyl CoA geraniol/citronellol acetyltransferase (Q5I6B5)
Organism: Rosa hybrid cultivar
Interaction partners:
Sequence:
MEKIEVSIISRDTIKPSAASSSLHPYKLSIIDQFTPTTYFPVIFFYPITDRVFNLPQTLTDLKNTVSQALTLYHPLSGRIKNNLYIDDFEAGIPYLEARVNFHMIDFLRLPKIEWLNEFVPMAPYRKETISEFLPLLGIQVNIFDSGIAIGVSFSHKINDGQTASCFLKSWVAIFRGYRNKIIHPNLSQAALLLPSRDDLPEKYVAMMERMWFGEKKVVTRRFVFDAKAISALQDEGKSEYVPKPSRVQALTGFLWKHQLAASRALSSGTSTRFSVASQTVNLRSKMNMKTTLDNAIGNIFLWASARLDLNDTAPGSSDLKLCDLVNLLNESIKEFNSDYLEILKGKEGYGGMCDLLDFMEEGSFVEPAPEFYSFSSWTRFFDQVDFGWGRPSWVGFSGRVETRNFTIFVETQCDDGIDAWVTVDEKQMAMLEQDPQFLAFASPNPRISIASSVGMD
Protein: Generative cell specific-1/HAP2 domain-containing protein (Q389Q2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Nodulin-like domain-containing protein
Sequence:
MPTETLSSVFVLVVLVTTSGLFPCTEAAFVASSSIEYCERSSNGEPFPCEKKMVVGLSVGSEQTIEAEEVVLLREAVDKTGDEKGKRVEFEPIRLVTTKSPVQYRYPIYYIRNFNAKPYEQRLRTSASSWCDDSSNPGSATCGVARDRRGDVIPYSQGFCCLCGACALSGICNPTSRSVGTCSVTGDTGMASCLRFSDLWYGGYTIGRGVVWYELQVKLSSGNNSTGGGSTGSKEFTMSLGPDKLTATSTEFGASARLIGDFAPPEMPLDLSGKMLFIPSEPRGHERVGAGYNEWIIVDTHLVSIRGTECNKVGVSYEGFATQGSRCDAYPGACLANQLEDYRDRDLEAETKGQQGKYMARFFAPFGFDPLANASAPAVAYQVTGTLSTMVTITISADKLNFVLSVSSGVIVGATVSGKVVHSYSRGSTITVTVLNTGDIEAQYTVVVGECTVNVQPMVAQTVYIPLQGSAQRRFTLIVQDSIEGEAKCNATLRNARGDVVDTRAISFGVKALKPSNGSQGGSTFENGRYSEEAKGESQCQQCSWFNLLCFLRHRCWWQPLVYVLPSVTLLMLLRRFLESQSRSRPRPQLHPDEHELRNTGAISSCHLPRAPYVNTVH
Protein: Kinesin-like protein (Q19633)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Kinesin-associated protein
- Kinesin-like protein klp-20
- Intraflagellar transport protein 52 C-terminal domain-containing protein
- Intraflagellar transport protein 88 homolog
- WD_REPEATS_REGION domain-containing protein
- Cytoplasmic dynein 2 heavy chain 1
- Tetratricopeptide repeat protein 30 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein che-13
- Kinesin motor domain-containing protein
Sequence:
MVEIMKKSSKQETVKVIVRCRPLSSQEIANNYSKIVHMRPQRGQIELKNPKEQDEPSKDFTFDAIYDENSTQSDLYEETFRDLVDSVLNGYNATIFAYGQTGTGKTHTMEGKSSDPEQRGVIYKCIDHIFEHMAASHNQEYLVRASYLEIYQEELRDLLEAESNKKLEIKERPDGGVYVKDLTSKLTRTVGEIHEVMIRGNGHRSVGRTNMNEHSSRSHAIFIITVECSRIGEDGESHITVGRLNLVDLAGSERQSKTGATGERFKEATKINLSLSALGNVISALVDAKSAHIPYRDSKLTRLLQDSLGGNSKTVMVACIGPASYNFEETLGTLRYANRAKNIKNQPKINEDPKDALLREFQEEIEMLREQLKQRKTRSRDGATQSFYDAERAKLEDDIEAIQKDDSLIKHEKDRLIREIQEKHDLLEKERIEQARVAERIANIQSRLIVGSEEDGRLESRTKEQHAQLEKKRRELAEQKRREREMVEALERQEEDTVDLKQTFSDLRTEVEAKTKKLKKMLIKLRQARNEIRDVSGAYSDERQDLDQTIAEVSKELKLKLLIVENFIPRDVSERIKERAEWNEDSFEWNVNAFQSTSSNSSTPLNNTIEVNEDGVFTRSSGADSGVSVSGGNGTPATSQFLDKRLVATPGCRRPMSMCERMLVETAREQFGAQRRPPISGSGSFVEATIPEETIRFCGENVVVFSALERFVPEVTDSDPSTFSNSMMMSARRPSIENLTIDASKVLVPILNQSTMILKNSKNGQARNDTMPPNGSMRRSQN
Protein: Carboxyvinyl-carboxyphosphonate phosphorylmutase, chloroplastic (EC 2.7.8.23) (Carboxyphosphonoenolpyruvate phosphonomutase) (CPEP phosphonomutase) (O49290)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18431481}.
Interaction partners:
- Malate synthase
- Acetolactate synthase, chloroplastic
- 2-hydroxyacyl-CoA lyase
Sequence:
MSMLMAVKTTSLCCSSLNLTASPTFRRNPRAARLVNPTARIQTRFHRLIEEQGIVLMPGCYDALSAAIVQQTGFSAGFISGYALSASLLGKPDFGLLTPPEMAATARSVCASAPNIPIIADADTGGGNALNIQRTVKDLIAAGAAGCFLEDQAWPKKCGHMRGKQVIPAEEHAAKIASARDAIGDSDFFLVARTDVRATSAKSGLEDAIARVNLYMEAGADASFVEAPRDDDELKEIGKRTKGYRVCNMIEGGVTPLHTPDELKEMGFHLIVHPLTALYASTRALVDVLKTLKENGSTRDHLQKMATFEEFNSLVDLDSWFELEARYSNLRNALGTTKS
Protein: Germin-like protein subfamily 1 member 20 (GLP2a copy 2) (GLP2b) (Germin type 2) (At-GERM2) (AtGER2) (P92996)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000250}.
Interaction partners:
- ABA-inducible protein-like
- GEM-like protein 1
Sequence:
MRVSQSLVPFAIIALVLSFVNAYDPSPLQDFCVAIDDLKGVFVNGRFCKDPKRVDAKDFFFSGLNVPGNTNNQVGSNVTTVNVDQIPGLNTMGISLVRIDYAPHGQNPPHTHPRGSEILVLVEGTLYVGFVSSNQDNNRLFAKVLHPGDVFVFPIGMIHFQVNVGKIPAVAFAGLSSQNAGVITIANTVFGSNPPIYPELLARAFQLDASVVKELQAKFGSI
Protein: Putative proteasome subunit alpha type-4-B (20S proteasome alpha subunit C-2) (Proteasome subunit alpha type-3) (F4JJE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-4
- Proteasome subunit beta type-6
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- Proteasome subunit beta type-7-A
- Proteasome subunit beta type-7-B
- Proteasome subunit alpha type-5-A
- Proteasome subunit alpha type-6-A
- Proteasome subunit beta type-2-B
Sequence:
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGNAGSAIGILAKDGVVLVGEKKVTSKLLQTSSSMEKMYKIDDHVACAVAGIMSDANILINTARVQAQRWDRNHGFQLYMSDPSGNYGGWQAAAVGANNQAAQSILKQDYKDDATREEVVQLAIKVLSKTMDSTSLTAEKLELAELYLTPSKCVKYHVHSPDSLTKLLVKHGVTQPAAETS
Protein: Ras-like GTP-binding protein Rho1 (P48148)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the developmental migration of tail hemocytes anteriorly along the ventral midline. May have a role in eye development.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton. Apical cell membrane {ECO:0000269|PubMed:23853710, ECO:0000269|PubMed:24535826}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lateral cell membrane {ECO:0000269|PubMed:24535826}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Rho-associated protein kinase
- Rho guanine nucleotide exchange factor 2, isoform D
- Rho GDP-dissociation inhibitor 3
- Protein diaphanous
- Cysts, isoform C
- Pebble, isoform B
- Serine/threonine-protein kinase N
- Dishevelled associated activator of morphogenesis, isoform D
- Anillin
- Rho GTPase-activating protein 190
Sequence:
MTTIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDPNTIRDLAKMKQEPVKPQEGRAMAEKINAFAYLECSAKSKEGVRDVFETATRAALQVKKRKKTRCLLL
Protein: Uncharacterized protein Rv1362c (P9WM01)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein Rv1363c
- 1,4-alpha-glucan branching enzyme GlgB
- Probable 1,4-alpha-glucan branching enzyme Rv3031
- Mce-family protein Mce2F
- Mce-family protein Mce1D
- Mce-family protein Mce1A
- Mce-family protein Mce1F
- Mce-family protein Mce4A
- Phthioceranic/hydroxyphthioceranic acid synthase
- Lipoprotein LprN
Sequence:
MTDDVRDVNTETTDATEVAEIDSAAGEAGDSATEAFDTDSATESTAQKGQRHRDLWRMQVTLKPVPVILILLMLISGGATGWLYLEQYRPDQQTDSGAARAAVAAASDGTIALLSYSPDTLDQDFATARSHLAGDFLSYYDQFTQQIVAPAAKQKSLKTTAKVVRAAVSELHPDSAVVLVFVDQSTTSKDSPNPSMAASSVMVTLAKVDGNWLITKFTPV
Protein: Meiotically up-regulated gene 163 protein (O94410)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MPFMNFRNFNFMPLLRPLNPVYKGAEHLCRKNIHNQVYNVETGKTIQILQDLVPLVLYRALPDAILDHHVELVIFPNSLNFPRIEGLTIYKFIFKTARLLLSSTYGSSAKRPIDIIHQLHSSMENKNVRYSMKCNWIASPNDEYTWVFHFDIDKKGIIYRHIIDNLERNRSRQCEKISALKPDPIE
Protein: Cell division protein FtsN (Q50991)
Organism: Neisseria gonorrhoeae
Interaction partners:
Sequence:
MSENKQNEVLTGYEQLKRRNRRRLVTASSLVAASCILLAAALSSDPADSNPAPQAGETGATESQTANTAQTPALKSAAENGETAADKPQDLAGEDKPSAADSEISEPENVGAPLVLINDRLEDSNIKGLEESEKLQQAETAKTEPKQAKQRAAEKVSATADSTDTVAVEKPKRSAEPKPQKAERTAEAKPKAKETKTAEKVADKPKTAAEKTKPDTAKSDSAVKEAKKADKAEGKKTAEKDRSDGKKHETAQKTDKADKTKTAEKEKSGKAGKKAAIQAGYAEKERALSLQRKMKAAGIDSTITEIMTDNGKVYRVKSSNYKNARDAERDLNKLRVHGIAGQVTNE
Protein: [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) (A0A0G2JTU9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- ATP synthase F
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase F
- Uncharacterized protein
- ATP synthase F
- Lysine-specific histone demethylase
- Histone H3.1
- Histone H3
- PHD finger protein 12
- Set1/Ash2 histone methyltransferase complex subunit ASH2
Sequence:
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKTFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEIVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPDLDLKEKVEAEVLSTDIQPSPERGTRMNIPPKRTRRVKSQSDSGEVNRNTELKKLQIFGAGPKVVGLAVGAKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLLPPLPDVPKGDWRCPKCVAEECNKPREAFGFEQAIREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPIKDGQRKMLPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVVMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCSCPMQNKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVNRVTEALSASFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCGSVAQLLLSKKQKHRQSSDSGKTRTKLTVEELKAFVQQLVSLPCVISQTRQVKNLLDDVEEFHERAQEAMMDETPDSSKLQVLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSMANLENIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLDALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKEIIEKEKEKDLDLEPLSDLEEGLEETRDAAMVVAVFKEREQKEIEAMHSLRAANLAKMTIVDRIEEVKFCICRKTASGFMLQCELCKDWFHNGCVPLPKSGSQKKGSSWQAKDVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPHQAMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCAKKQGPDSPGHAPPPPFIMSYKLPMEDLKETS
Protein: Translation initiation factor IF-2, mitochondrial (IF-2(Mt)) (IF-2Mt) (IF2(mt)) (O59683)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
Subcellular location: Mitochondrion.
Interaction partners:
- Small ribosomal subunit protein uS3
- Probable translation initiation factor
- Elongation factor Ts, mitochondrial
- Large ribosomal subunit protein uL15m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL11m
- Small ribosomal subunit protein uS17m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein uL24
Sequence:
MAFLSACTSWRHVHNAGFTFITKFPFVRNVHKLSYHISPLSSRFSLADISVKENNHPNGPQLRLQTHFFHSSSPMHATKGFRFPKSSTPLTLPAVLSVASFANLLQIPTRRILRDLNRLGIKDVFPEYLITYEYSSLLAEEYGFDVQEAAAYSAPSPKSLNSKKDSGPLRPPVVTLMGHVDHGKTTLLDAFRKSTIASTEHGGITQKIGAFTVPFDKGSKFITFLDTPGHMAFEAMRKRGANIADIVVLVVAGDDGVKPQTVEAIKHIQSADVPVVVALTKSDRPGTPIHKIYEQLLNNGIQVEALGGETQIIPISAKTGKGIPELEAAILTLAEIMEIRASPRDPFQGWIVESSVTKGVGSSATVVVKRGTVKKGMYLVAGKSWCKVRSLVDVNKKSIKQVLPGQAAQVYGWKDLPIAGDLAYEVKSESEAKRILSDIYRQSNEQNFYELAESQNEQRVSALAAKKSGPAAIQEETSVSKSFNIIAKCEDTGSMEALSDYLKPLQFGKVKSRVLYTGVGPVTETDIERAETSDAIIISFGVSVPKATFRLAEKHNVKLLFHNVIYHLMDDVRKLFALRLPPILVQRVTGEAIISAIFDIKAKRAVVHVAGCRVTNGTIEKSHKIRLVRNDKIIWSGEIDSLKHLKEEVTSIKKGRECGILLKNFDEIVTGDKLQTFVEEYKPPDF
Protein: Tumor protein p73 (p53-like transcription factor) (p53-related protein) (Q9JJP2)
Organism: Mus musculus (Mouse)
Function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression, essential for the positive regulation of lung ciliated cell differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:15113856}. Cytoplasm {ECO:0000250}. Note=Accumulates in the nucleus in response to DNA damage. {ECO:0000269|PubMed:15113856}.
Interaction partners:
- E3 ubiquitin-protein ligase Mdm2
- Transcriptional coactivator YAP1
- Cellular tumor antigen p53
- Tumor protein 63
- WW domain-containing transcription regulator protein 1
- Apoptosis-stimulating of p53 protein 2
- RelA-associated inhibitor
- E3 ubiquitin-protein ligase Itchy
- Bcl-2-like protein 1
- Apoptosis-stimulating of p53 protein 1
Sequence:
MAQTSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGTSEASGSEESNMDVFHLQGMAQFNLLSSAMDQMGSRAAPASPYTPEHAASAPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLAQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILVIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRAFKQSPPAIPALGTNVKKRRHGDEDMFYMHVRGRENFEILMKVKESLELMELVPQPLVDSYRQQQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGVNKLPSVNQLVGQPPPHSSAAGPNLGPMGSGMLNSHGHSMPANGEMNGGHSSQTMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKVPDQYRMTIWRGLQDLKQSHDCGQQLLRSSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGAGAVTGPDEWADFGFDLPDCKSRKQPIKEEFTETESH