wanglab/gogpt-training-data huggingface dataset:
Protein: Chloride channel protein (Q8LPA2)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
Interaction partners:
Sequence:
MDGHPSPRSHHQPPPPERDGSFNYDIESMDGGGGAWRGRYESSEVLLRYDDEAGGGPRQPLLRKRTMNTTSQIAIVGANVCPIESLDYEIVENDLFKQDWRSRKKKQIFQYIVLKWALVLLIGMLTGIVGFFNNLAVENIAGLKLLLTSDLMLKQKCRYFTAFLAYGGCNLVLATTAAAICAYIAPAAAGSGIPEVKAYLNGVDAYSILAPSTLFVKIFGSILGVSAGFVLGKEGPMVHTGACIANLLGQGGSRKYHLTWNWLRYFKNDRDRRDLITCGSAAGVAAAFRAPVGGVLFALEEAASWWRSALLWRTFFTTAVVAVVLRGLIEFCRSGKCGLFGQGGLIMFDLSSTIPTYTAQDVVAIIVLGIIGGVFGGLFNFLLDRILRAYSIINERGPPFKILLTMIISIITSACSYGLPWLAPCTPCPADAAEECPTIGRSGNFKNFQCPPGHYNGLASLFFNTNDDAIRNLFSSGTEKEFHMSTLFVFFTAIYCLGLVTYGIAVPSGLFIPVILAGATYGRIVGTLLGPISDLDPGLFALLGAASFLGGTMRMTVSVCVILLELTNDLHMLPLVMLVLLISKTIADSFNKGVYDQIVVMKGLPFMEAHAEPFMRNLVAGDVVSGPLITFSGVEKVGNIVHALRITGHNGFPVVDEPPVSEAPELVGLVLRSHLLVLLKGRSFMKEKVKTSGSFVLRRFGAFDFAKPGSGKGLKIEDLDLTDEELDMYVDLHPITNTSPYTVVETMSLAKAAVLFRALGLRHLLVVPKTPGRPPIVGILTRHDFMHEHIHGLFPNLGKSH
Protein: Potassium transporter 5 (AtHAK1) (AtHAK5) (AtPOT5) (Q9M7K4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High-affinity potassium transporter. Can also transport rubidium and cesium (Ref.1). Is essential with AKT1 for high-affinity potassium uptake in roots during seedling establishment and postgermination growth under low potassium conditions. Mediates potassium uptake by plant roots in response to low potassium conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by the calcium sensors calcineurin B-like genes CBL1, CBL8, CBL9 and CBL10, and by phosphorylation by CIPK23.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Potassium channel AKT1
- Calcineurin B-like protein 1
- CBL-interacting serine/threonine-protein kinase 23
- Potassium channel SKOR
- Ethylene-responsive transcription factor RAP2-11
- Calcineurin B-like protein 9
- Potassium channel GORK channel)
- Calcineurin B-like protein 10
- Potassium channel KAT3
- Protein NRT1/ PTR FAMILY 6.3
Sequence:
MDGEEHQIDGDEVNNHENKLNEKKKSWGKLYRPDSFIIEAGQTPTNTGRRSLMSWRTTMSLAFQSLGVVYGDIGTSPLYVYASTFTDGINDKDDVVGVLSLIIYTITLVALLKYVFIVLQANDNGEGGTFALYSLICRYAKMGLIPNQEPEDVELSNYTLELPTTQLRRAHMIKEKLENSKFAKIILFLVTIMGTSMVIGDGILTPSISVLSAVSGIKSLGQNTVVGVSVAILIVLFAFQRFGTDKVGFSFAPIILVWFTFLIGIGLFNLFKHDITVLKALNPLYIIYYFRRTGRQGWISLGGVFLCITGTEAMFADLGHFSVRAVQISFSCVAYPALVTIYCGQAAYLTKHTYNVSNTFYDSIPDPLYWPTFVVAVAASIIASQAMISGAFSVISQSLRMGCFPRVKVVHTSAKYEGQVYIPEINYLLMLACIAVTLAFRTTEKIGHAYGIAVVTVMVITTLMVTLIMLVIWKTNIVWIAIFLVVFGSIEMLYLSSVMYKFTSGGYLPLTITVVLMAMMAIWQYVHVLKYRYELREKISRENAIQMATSPDVNRVPGIGLFYTELVNGITPLFSHYISNLSSVHSVFVLISIKTLPVNRVTSSERFFFRYVGPKDSGMFRCVVRYGYKEDIEEPDEFERHFVYYLKEFIHHEHFMSGGGGEVDETDKEEEPNAETTVVPSSNYVPSSGRIGSAHSSSSDKIRSGRVVQVQSVEDQTELVEKAREKGMVYLMGETEITAEKESSLFKKFIVNHAYNFLKKNCREGDKALAIPRSKLLKVGMTYEL
Protein: 3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC 2.3.1.293) (Beta-ketoacyl-ACP synthase 1) (KAS 1) (Beta-ketoacyl-acyl carrier protein synthase KasA) (Meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I) (P9WQD9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis. Catalyzes the elongation of long chain acyl-ACP substrates by the addition of two carbons from malonyl-ACP to an acyl acceptor. Involved in the initial extension of the mycolate chain and forms monounsaturated fatty acids that averaged 40 carbons in length.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Malonyl CoA-acyl carrier protein transacylase
- Meromycolate extension acyl carrier protein
- Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta6 subunit
- Enoyl-[acyl-carrier-protein] reductase
- Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III
- Probable biotin-dependent acyl-coenzyme A carboxylase beta3 subunit
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- 3-oxoacyl-[acyl-carrier-protein] reductase MabA
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Alkyl hydroperoxide reductase C
Sequence:
MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKIGGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGARAGVMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFGEAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSPADIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNSFGFGGHNVALAFGRY
Protein: Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] (P62982)
Organism: Rattus norvegicus (Rat)
Function: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
Subcellular location: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: [Small ribosomal subunit protein eS31]: Nucleus, nucleolus {ECO:0000250|UniProtKB:P62979}.
Interaction partners:
- Small ribosomal subunit protein uS7
- Ubiquitin-like protein FUBI
- Ubiquitin-ribosomal protein eL40 fusion protein
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS9
Sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMGSHFDRHYCGKCCLTYCFNKPEDK
Protein: Proteasome subunit alpha type-1 (PROS-Dm35) (Proteasome 35 kDa subunit) (P12881)
Organism: Drosophila melanogaster (Fruit fly)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-5
- Proteasome subunit beta type-1
- Proteasome subunit beta type-3
- Proteasome subunit beta type-4
- Proteasome subunit beta
- Proteasome subunit beta
- Proteasome subunit alpha type-4
- Proteasome subunit beta
Sequence:
MFRNQYDSDVTVWSPQGRLHQVEYAMEAVKLGTATVGLKNKDYAVLVALCKPTSELSDTQRKIIPIDDHLGISIAGLTADARVLSRYLRSECLNYKHSYDTTYPVSRLITNLGNKMQTTTQRYDRRPYGVGLLVAGYDERGPHIYQVTPSATFFNCKANSIGSRSQSARTYLEKNLNKFLDSSKDEIIRHGIRAILGTLPTDEQGKDAGQYDITVAIVGKDQPFTILSNKDSAKHVAIAKENDNDTPRNDDDDDRPSPPEEPAAGPRDPEVLVATEQRP
Protein: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) (P47543)
Organism: Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium)
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Fructose-bisphosphate aldolase
- Glucose-6-phosphate isomerase
- Enolase
- Uridine kinase
- Transketolase
- Chaperone protein DnaK
- L-lactate dehydrogenase
- Phosphate acetyltransferase
Sequence:
MAAKNRTIKVAINGFGRIGRLVFRSLLSKANVEVVAINDLTQPEVLAHLLKYDSAHGELKRKITVKQNILQIDRKKVYVFSEKDPQNLPWDEHDIDVVIESTGRFVSEEGASLHLKAGAKRVIISAPAKEKTIRTVVYNVNHKTISSDDKIISAASCTTNCLAPLVHVLEKNFGIVYGTMLTVHAYTADQRLQDAPHNDLRRARAAAVNIVPTTTGAAKAIGLVVPEANGKLNGMSLRVPVLTGSIVELSVVLEKSPSVEQVNQAMKRFASASFKYCEDPIVSSDVVSSEYGSIFDSKLTNIVEVDGMKLYKVYAWYDNESSYVHQLVRVVSYCAKL
Protein: Aprataxin-like protein (EC 3.-.-.-) (Q8MSG8)
Organism: Drosophila melanogaster (Fruit fly)
Function: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- FI04011p
- Tyrosyl-DNA phosphodiesterase 1
- DNA ligase 4
- FI07206p
- ATP-dependent DNA helicase II subunit 2
- N-glycosylase/DNA lyase
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- Recombination repair protein 1 endonuclease)
Sequence:
MSWSSALIKDISKPENLIISSEIAVVIADKFPKAQHHYLVLPLADIPSIFHLNRSHLSLLEELHLLARNVVEVKGVRWQDFNVGFHAEPSMQRLHLHVISKDFVSTSLKTKKHWNSFNTELFVPYTKLYAQLEKENSISRLPKSLKDELLAKPLICNQCEFVARNLPSLKGHLVGHLQDPKSVCQRVRLGNQFFPTAGYRTSELAYCFDFVDFYEYKKQMEVDKLAYIRDELQRKLNDKRNFLIESDRAVVMKADYPKSQYHFRVVAKEEFRDITQLTEAQLPLLDHMMDLANQIIEKQKHLESRNFLIGFKVNTFWNRLNLHVISNDFYSMAMKRISHWNSFNTELFMPFQIAYMMLSVQGSIESISEETYNNLQEKTPLRCNQCEFVTNMLLDLKAHLYQHWQRKEDERDQKKKVDKIIQMISETKLDEAEAKPKLLNEEEPIQAQPVAAIAQYPNEHLGKPLTPQQQPGKQQAQNVYDKNINGPSVNMMNQNNPNNPFRNTPHLNRQSQKPPHPRSGPRGPMAPWTGPRFPCHQQQNRFRPPGFNACRQPYPPYHSGHQQFPNASSVGGGQTGLPGQGQGPRPKWNSNKIFNQQNRQNTVQAQPQAQNQQTNQQQIQNSNKNQTPKKKPWKNRLQPVGKVQNQGGANRDPAPPSNSKPS
Protein: Spindle assembly abnormal protein 6 homolog (HsSAS-6) (Spindle assembly defective protein 6) (Q6UVJ0)
Organism: Homo sapiens (Human)
Function: Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:24107630, ECO:0000269|PubMed:31722219}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15572125, ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:17681131}. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis. {ECO:0000250|UniProtKB:Q80UK7}.
Interaction partners:
- Centrosomal protein of 135 kDa
- Centrosomal P4.1-associated protein
- Serine/threonine-protein kinase PLK4
- SCL-interrupting locus protein
- Centrosomal protein of 152 kDa
- Centriolar coiled-coil protein of 110 kDa
- Centrosomal protein of 192 kDa
- Centrosomal protein of 295 kDa
- Pericentrin
- Tubulin gamma-1 chain
Sequence:
MSQVLFHQLVPLQVKCKDCEERRVSIRMSIELQSVSNPVHRKDLVIRLTDDTDPFFLYNLVISEEDFQSLKFQQGLLVDFLAFPQKFIDLLQQCTQEHAKEIPRFLLQLVSPAAILDNSPAFLNVVETNPFKHLTHLSLKLLPGNDVEIKKFLAGCLKCSKEEKLSLMQSLDDATKQLDFTRKTLAEKKQELDKLRNEWASHTAALTNKHSQELTNEKEKALQAQVQYQQQHEQQKKDLEILHQQNIHQLQNRLSELEAANKDLTERKYKGDSTIRELKAKLSGVEEELQRTKQEVLSLRRENSTLDVECHEKEKHVNQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVVLEENGEKNQVQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVKKLEESKQLLKNNEKLITWLNKELNENQLVRKQDVLGPSTTPPAHSSSNTIRSGISPNLNVVDGRLTYPTCGIGYPVSSAFAFQNTFPHSISAKNTSHPGSGTKVQFNLQFTKPNASLGDVQSGATISMPCSTDKENGENVGLESKYLKKREDSIPLRGLSQNLFSNSDHQRDGTLGALHTSSKPTALPSASSAYFPGQLPNS
Protein: ETS variant transcription factor 5 (D4AC56)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004019}.
Interaction partners:
- COP1, E3 ubiquitin ligase
- DET1 partner of COP1 E3 ubiquitin ligase
- B-cell CLL/lymphoma 6 member B protein
- Promyelocytic leukemia zinc finger protein
Sequence:
MDGFCDQQVPFMVPGKSRSEDCRGRPVIDRKRKFVDTDLAHDSEELFQDLSQLQEAWLAEAQVPDDEQFVPDFQSDNLVLHAPPPTKIKRELHSPSSELSSCSHEQALGAKYGEKCLYNYCAYDRKPPSGFKPLTPPATPLSPTHQNSLFPPPQATLPTSALAPGAGPVQGVGPAPTPHSLPEPGSQQQTFAVPRPPHQPLQMPKMMPESQYPSEQRFQRQLSEPCRPFPPQSGVPGDTRPSYQRQMSEPVVPAAPPPLQGFKQEYHDPLYEHGVPGMPGPPAHGFQSPMGIKQEPRDYCADSEVPNCQSPYMRGRYFSSNHEGFTYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGPPYQRRGSLQLWQFLVTLLDDPANAHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAFPDNQRPFLKAESDCPLNEEDTLPLTHFEDSPAYLLDMDRCSGLPYAEGFAY
Protein: Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial (Q9D172)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
Sequence:
MAAVRVLVAPRLASALLPLSRYHRAPSQRAALHSSAPRPGARVALVLSGCGVYDGTEIHEASAILVHLSRGGAEVQIFAPDVPQMHVIDHTKGEPSERESRNVLAESARIARGKITSLAQLNAANHDAAIFPGGFGAAKNLSTFAVDGKDCKVNKEVERVLKEFHGAKKPIGLCCIAPVLAAKVIKGVEVTVGHEQEEGGKWPYAGTAEAIKALGAKHCVKGVTEAHVDQKNKVVTTPAFMCETALHHIHDGIGAMVKNVLELTGK
Protein: Pyridoxal 5'-phosphate synthase subunit PdxS (PLP synthase subunit PdxS) (EC 4.3.3.6) (Pdx1) (P9WII9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
Interaction partners:
- Pyridoxal 5'-phosphate synthase subunit PdxT
- Pyridoxine 5'-phosphate oxidase
- Probable acyl-CoA thioesterase II TesB2
- Probable transcriptional regulatory protein Rv2603c
- Transketolase
- Transaldolase
- Octanoyltransferase
- Ribokinase
- Ribose-phosphate pyrophosphokinase
- Glyceraldehyde-3-phosphate dehydrogenase
Sequence:
MDPAGNPATGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAVMALERVPADIRAQGGVSRMSDPDMIEGIIAAVTIPVMAKVRIGHFVEAQILQTLGVDYIDESEVLTPADYAHHIDKWNFTVPFVCGATNLGEALRRISEGAAMIRSKGEAGTGDVSNATTHMRAIGGEIRRLTSMSEDELFVAAKELQAPYELVAEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGAPEHRAAAIVKATTFFDDPDVLAKVSRGLGEAMVGINVDEIAVGHRLAQRGW
Protein: At1g13880 (ELM2 domain-containing protein) (F16A14.9) (Q9LMG9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGFKRTFDAEDVQELNVKNGRQISYCNKLAKLDEGVPYRLSLEKPGVVGYDISDLYGYKCEDNVDKGFETNAPFSWITTGLSEEDSQSGATIQSTISHESPESDIPWRPVCSGEEDGYWCPISPRKTVPIGSDYQADIPECVKEEANDQSGQGVGYDEEQVTGKCVIPMPDCETEVCKIGKGRKECICLDKGSIRCVQQHIMENREDLFATIGYDRCLDIGLCEMGEEVAARLTEDEEDLFHEIVYSNPVSMDRDFWKHLKSAFPSRTMKEIVSYYFNVFILRRRAIQNRSKSLDVDSDDDEWQVEYDNTFYGAETPSDDKAEKSLSRDEGEEVNANEDSYMSFENQSNAIYSRCPVRNREESNIGNYWRHCNDLVDQSYSFDPCDSILPDHCWTKNIDLLPTSNIIDEIFGQDHPWDDFSRGK
Protein: Zcf28p (A0A1D8PEH1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- F-actin-capping protein subunit beta
- Dynactin subunit 4
Sequence:
MNQDSTTLNFPTSENETTSTKTYTINSISPISVDSFNIDTTLGFESVSPNILNGFPGNDIPLQQQQQEHTGGYENRDEFLLTNQQMLINEVDSLIMLSNINYDESPASSSLSSSMIFPNTSNSMYQISENSLSSPFSQFGISLHSSTSTSVTNNCDGITGQKSKSTTKVLKKPKGELTTTIRKKKYSPRSRHACNNCRLKKLKCDEQKPQCSRCSKKGYDCVYHFNVQFKQDVEARGKRFGREGINS
Protein: Plasmepsin V (PfPMV) (EC 3.4.23.-) (Plasmepsin 5) (Q8I6Z5)
Organism: Plasmodium falciparum (isolate 3D7)
Function: During the asexual blood stage, plays an essential role in the export of several proteins into the host erythrocytes by cleaving the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence. Specifically, cleaves after the leucine residue in the RxLxE/Q/D (or RxLxxE) motif of exported proteins including RESA, EMP2, EMP3, KAHRP, RIF/Rifin and STEVOR. Also, by regulating protein export, plays an essential role in gametocyte development and thus, parasite transmission to the mosquito vector (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20117149, ECO:0000269|PubMed:20130643, ECO:0000269|PubMed:20130644, ECO:0000269|PubMed:24983235, ECO:0000269|PubMed:25849462, ECO:0000269|PubMed:30127496}; Single-pass type I membrane protein {ECO:0000269|PubMed:25849462}. Note=During gametogenesis, localizes to the perinuclear ER in stage I-II gametocytes, and relocalizes towards the cell periphery as the ER redistributes in the cell in stage III-IV gametocytes (By similarity). Partially colocalizes with SPC25 in the endoplasmic reticulum (PubMed:30127496). {ECO:0000250|UniProtKB:W7JPD9, ECO:0000269|PubMed:30127496}.
Interaction partners:
Sequence:
MNNYFLRKENFFILFCFVFVSIFFVSNVTIIKCNNVENKIDNVGKKIENVGKKIGDMENKNDNVENKNDNVGNKNDNVKNASSDLYKYKLYGDIDEYAYYFLDIDIGKPSQRISLILDTGSSSLSFPCNGCKDCGIHMEKPYNLNYSKTSSILYCNKSNCPYGLKCVGNKCEYLQSYCEGSQIYGFYFSDIVTLPSYNNKNKISFEKLMGCHMHEESLFLHQQATGVLGFSLTKPNGVPTFVDLLFKHTPSLKPIYSICVSEHGGELIIGGYEPDYFLSNQKEKQKMDKSDNNSSNKGNVSIKLKNNDKNDDEENNSKDVIVSNNVEDIVWQAITRKYYYYIKIYGLDLYGTNIMDKKELDMLVDSGSTFTHIPENIYNQINYYLDILCIHDMTNIYEINKRLKLTNESLNKPLVYFEDFKTALKNIIQNENLCIKIVDGVQCWKSLENLPNLYITLSNNYKMIWKPSSYLYKKESFWCKGLEKQVNNKPILGLTFFKNKQVIFDLQQNQIAFIESKCPSNLTSSRPRTFNEYREKENIFLKVSYINLYCLWLLLALTILLSLILYVRKMFYMDYFPLSDQNKSPIQEST
Protein: Calcium load-activated calcium channel homolog (CLAC channel) (Q19714)
Organism: Caenorhabditis elegans
Function: Calcium-selective channel required to prevent calcium stores from overfilling.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UM00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UM00}.
Interaction partners:
- PAT complex subunit CCDC47
- Nicalin
- Phenylalanine--tRNA ligase beta subunit
- Translocon Sec61/SecY plug domain-containing protein
- Protein transport protein Sec61 subunit beta
- ER membrane protein complex subunit 3
- Protein transport protein Sec61 subunit gamma
- BOS complex subunit TMEM147
- Uncharacterized protein
- 60S ribosomal protein L29
Sequence:
MLGDCLLIIAIAFGTALAGEGITWLLVYRSDHYKRLKADMDKKTKKLEKKKQEVGDTNDKNIKRKLEREEERLKATNRDMSMFKMKSMFAIGLAFTALLSTFNSIFEGRVVAKLPFYPIGFIQGLSHRNLIGEDMTDCSFIFLYILCTMTVRQNLQKILGFAPSRAMARQQSSPWAPPNSQMNYLR
Protein: Semaphorin-7A (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108) (Q9QUR8)
Organism: Mus musculus (Mouse)
Function: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17377534}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17377534}; Extracellular side {ECO:0000269|PubMed:17377534}.
Interaction partners:
- Plexin-C1
- Integrin beta-1
- Plexin-A1
- Plexin-B1
- Plexin-A4
- Plexin-A2
- Plexin-D1
Sequence:
MTPPPPGRAAPSAPRARVLSLPARFGLPLRLRLLLVFWVAAASAQGHSRSGPRISAVWKGQDHVDFSQPEPHTVLFHEPGSFSVWVGGRGKVYHFNFPEGKNASVRTVNIGSTKGSCQDKQDCGNYITLLERRGNGLLVCGTNARKPSCWNLVNDSVVMSLGEMKGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNRNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDRVFRTSSLKGYHMGLPNPRPGMCLPKKQPIPTETFQVADSHPEVAQRVEPMGPLKTPLFHSKYHYQKVVVHRMQASNGETFHVLYLTTDRGTIHKVVESGDQDHSFVFNIMEIQPFHRAAAIQAISLDADRRKLYVTSQWEVSQVPLDMCEVYSGGCHGCLMSRDPYCGWDQDRCVSIYSSQRSVLQSINPAEPHRECPNPKPDEAPLQKVSLARNSRYYLTCPMESRHATYLWRHEENVEQSCEPGHQSPSCILFIENLTARQYGHYRCEAQEGSYLREAQHWELLPEDRALAEQLMGHARALAASFWLGVLPTLILGLLVH
Protein: Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) (Q5BP74)
Organism: Xenopus laevis (African clawed frog)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity).
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:15893604}. Nucleus {ECO:0000269|PubMed:15893604}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15893604}.
Interaction partners:
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAASEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAAEDAERERREREERLRHTRNPAVRGLPSTASGRLRGTQEVTPSTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTSRQDTSRMSTSQIPSRVTSSGLPSTVHR
Protein: Polygalacturonase inhibitor 1 (Polygalacturonase-inhibiting protein 1) (PGIP-1) (Q9M5J9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inhibitor of fungal polygalacturonase. It is an important factor for plant resistance to phytopathogenic fungi.
Subcellular location: Secreted, cell wall {ECO:0000250|UniProtKB:P58822}. Membrane; Peripheral membrane protein.
Interaction partners:
- Protein SENSITIVE TO PROTON RHIZOTOXICITY 2
- Protein SENSITIVE TO PROTON RHIZOTOXICITY 1
- Plant intracellular Ras-group-related LRR protein 8
Sequence:
MDKTATLCLLFLFTFLTTCLSKDLCNQNDKNTLLKIKKSLNNPYHLASWDPQTDCCSWYCLECGDATVNHRVTALTIFSGQISGQIPAEVGDLPYLETLVFRKLSNLTGTIQPTIAKLKNLRMLRLSWTNLTGPIPDFISQLKNLEFLELSFNDLSGSIPSSLSTLPKILALELSRNKLTGSIPESFGSFPGTVPDLRLSHNQLSGPIPKSLGNIDFNRIDLSRNKLQGDASMLFGSNKTTWSIDLSRNMFQFDISKVDIPKTLGILDLNHNGITGNIPVQWTEAPLQFFNVSYNKLCGHIPTGGKLQTFDSYSYFHNKCLCGAPLEICK
Protein: Evasin P546 (A0A023FBW7)
Organism: Amblyomma cajennense (Cayenne tick) (Acarus cajennensis)
Function: Salivary chemokine-binding protein which binds to host chemokines CCL1, CCL3, CCL5 and CCL22.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MKVLLYIAASCLMLLALNVSAENTQQEEEDYDYGTDTCPFPVLANKTNKAKFVGCHQKCNGGDQKLTDGTACYVVERKVWDRMTPMLWYSCPLGECKNGVCEDLRKKEECRKGNGEEK