wanglab/gogpt-training-data huggingface dataset:
Protein: Transportin 3 (C9J7E5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPKKPFSNAVCRHSLLFGQNITSEISNCEYLPPVLRENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLFR
Protein: Kinocilin (Q307W7)
Organism: Mus musculus (Mouse)
Function: May play a role in stabilizing dense microtubular networks or in vesicular trafficking.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Signal transducer CD24
Sequence:
MDIPISTRDFRCLQLACVALGLVAGSIIIGVSVSKAAAAVGGIFLGAAGLGLLIFAYPFLKARFNLDHILPAIGNLRIHPNSGPDHGEGRSSNNSNKEGARSGLSTVTRTLEKLKPGGRGTEEG
Protein: Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) (O75469)
Organism: Homo sapiens (Human)
Function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12606758}.
Interaction partners:
- Retinoic acid receptor RXR-alpha
- Nuclear receptor coactivator 1
- Cytochrome P450 3A4)
- Nuclear receptor subfamily 0 group B member 2
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Solute carrier family 53 member 1
- Bifunctional glutamate/proline--tRNA ligase
- Nuclear receptor corepressor 2
- Cytochrome P450 3A7
- Cytochrome P450 2B6
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
Protein: glycine hydroxymethyltransferase (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) (A9LDD9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Phosphoribosylglycinamide formyltransferase.
- Phosphoserine phosphatase.
- Thymidylate synthase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial 2, methenyltetrahydrofolate cyclohydrolase)
- Methylenetetrahydrofolate reductase
- Monofunctional C1-tetrahydrofolate synthase, mitochondrial
- Methylenetetrahydrofolate dehydrogenase
- 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.
- Glycine dehydrogenase
- Glycine cleavage system H protein
Sequence:
MLTLTLRQITRPLCRRVQRSSAAVCVRADGSWTGQESLSQDDPEMWDLLLKEKDRQCRGLELIASENFCSRAALEAQGSCLNNKYSEGYPGKRYYGGAEVVDQIELLCQKRALEAFDLDPQLWGVNVQPYSGSPANFAAYTAVLNPHERIMGLDLPDGGHLTHGYMSDVRRISATSIYFESMPYKLNPKTGLIDYDQMELTAKLFRPKLIIAGTSAYARLIDYCRIKTLCSEINAYMLADMAHISGLVAAKAIPSPFQHADIVTTTTHKSLRGSRAGLIFYRKGVRSVDKKGKEIMYDLEEKVNFSVFPSLQGGPHNHAIAGVAVALKQATSPMFREYIAQVLKNSKAMAAALLDKGYTLVSGGTDNHLVLVDLRPQGMDGARAERVLELVSITANKNTCPGDKSALTPGGLRLGTPALTSRQLKECDFQKVVEFIHQGIQIGQDVKKKTKKLSDFKSFLLEDAETVSRIADLRSRVEAFARPFPMPGFHDH
Protein: DhcR, transcriptional regulator (Q9I2B1)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- 3-oxoadipate CoA-transferase
- GbuR
- 3-oxoadipate CoA-transferase
- Probable transcriptional regulator
- Probable transcriptional regulator
- Probable transcriptional regulator
- HTH-type transcriptional activator BauR
- ABC-type glycine betaine transport system substrate-binding domain-containing protein
- Probable transcriptional regulator
- Probable transcriptional regulator
Sequence:
MTVKQLRAFLAVAQSLSFAQAGERLHLSQPALSLAIKSLEESLGGPLLERTTRSVSLTPEGETLLPLALRLLADWDNTEELLRQHFTLQLGKVSIAAMPSFAGNLLPLVLKTFRERHPRVNVAVHDVINEQVLEMVRNRRVELGIAFEPESLENLEFTPFYSDRFVAVVPTGSSLSGQERISWRELLGEPFITLQRPSAVRLLLEESVAAEHGRLPVAFESHQLVTVGRMVAQGLGVSAVPTLCIQQMQELGARCLPLYAPQVQRRVGLLRLSEHKLSTAAQALSDVLLHGTDWRSLALPQDQSTE
Protein: 67 protein (Tegument protein) (O41968)
Organism: Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Subcellular location: Host nucleus inner membrane {ECO:0000256|ARBA:ARBA00043948}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00043948}.
Interaction partners:
Sequence:
MANQKKLIDELCGIVTSFLCPQGIVPEIEKCSTKLPHFSKGGTKPVCTVRLQHGHTYHIEFVYKFWQHILGQLRLPLQPCFILTNNGLATTLKCFMSPPRDIDFQYGNRVNMACDVNLEKNSCVIIEDEDFLRFKSYHVFPKDVPIYNSMVVCRTYITDMRNAVQFFVVKPGNRRKIVHMLESIEEMPETPQQLYFCGGRGYKMIGAGLSLFFFAAIVALASKLVW
Protein: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) (P20651)
Organism: Rattus norvegicus (Rat)
Function: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (By similarity). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P16298}.
Interaction partners:
- Calcineurin subunit B type 1
- Calcineurin subunit B type 2
- Protein phosphatase 3 catalytic subunit alpha
- Serine/threonine-protein phosphatase
- Calmodulin-1
- Nuclear factor of activated T-cells, cytoplasmic 3
- Nuclear factor of activated T-cells 1
- Calmodulin-like protein 3
- Calmodulin-like protein 4
- Nuclear factor of activated T-cells 2
Sequence:
MAAPEPARAAPPPPPPPPPPLGADRVVKAVPFPPTHRLTSEEVFDMDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGSSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHTTENHGTGNHSAQ
Protein: DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Q91WD1)
Organism: Mus musculus (Mouse)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC5
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase III subunit RPC3
- DNA-directed RNA polymerase III subunit RPC8
- DNA-directed RNA polymerase III subunit RPC10
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
Sequence:
MSEGNAAGEPSNPGGPRPLLSGGRGLIGRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFTPNIISRKIKEEPKEEVTMKKEKRERDRDRQREGHGRGRGRPEVIQSHSIFEQGPAEMMKKKGNWDKTVDMSDMGPSHIINIKKEKRETDEETKQILRMLEKDDFIDDPGLKNDTRNMPVQLPLAHSGWLFKEESEEPEAKPFSAGPKEEDMEVDVPAVKVKEEPRDEEEEAKVKAPPRAARKTPGLPKDVSVAELLRELSLMKDEELLFLQLPDTLPGQPPTQDIKPVKTEVQGEDGQMVVIKQEKDREARLAENACTLADLTEGQVGKLLIRKSGKVQLLLGKVTLDVTMGTTCSFLQELVSVGLGDSRTGEMTVLGHVKHKLVCSPDFESLLDHKHR
Protein: Complement factor H-related protein 2 (FHR-2) (DDESK59) (H factor-like 3) (H factor-like protein 2) (P36980)
Organism: Homo sapiens (Human)
Function: Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.
Subcellular location: Secreted.
Interaction partners:
- Complement C3
- Complement factor H-related protein 1
- Complement factor H-related protein 5
- C4b-binding protein beta chain
- Myosin-binding protein H
Sequence:
MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
Protein: Dickkopf-like protein 1 (Cancer/testis antigen 34) (CT34) (Protein soggy-1) (SGY-1) (Q9UK85)
Organism: Homo sapiens (Human)
Function: Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9QZL9}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9QZL9}. Note=Localized specifically to the crescent shaped acrosome at the apex of the sperm head. {ECO:0000250|UniProtKB:Q9QZL9}.
Interaction partners:
- Protein KASH5
- Low-density lipoprotein receptor-related protein 5
- Protein Wnt-2b
- Cancer-associated gene 1 protein
- Dickkopf-related protein 1
- Ras-related protein Rab-11B
Sequence:
MGEASPPAPARRHLLVLLLLLSTLVIPSAAAPIHDADAQESSLGLTGLQSLLQGFSRLFLKGNLLRGIDSLFSAPMDFRGLPGNYHKEENQEHQLGNNTLSSHLQIDKMTDNKTGEVLISENVVASIQPAEGSFEGDLKVPRMEEKEALVPIQKATDSFHTELHPRVAFWIIKLPRRRSHQDALEGGHWLSEKRHRLQAIRDGLRKGTHKDVLEEGTESSSHSRLSPRKTHLLYILRPSRQL
Protein: Caytaxin (Q8BHE3)
Organism: Mus musculus (Mouse)
Function: Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites.
Subcellular location: Cell projection, axon {ECO:0000250|UniProtKB:Q1M168}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q1M168}. Presynapse {ECO:0000269|PubMed:17157273}. Mitochondrion {ECO:0000250|UniProtKB:Q1M168}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q1M168}. Cytoplasm {ECO:0000250|UniProtKB:Q86WG3}.
Interaction partners:
Sequence:
MGTTEATLRMENVDVRDEWQDEDLPRPLPEDTGVERLGGAVEDSSSPPSTLNLSGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLGNGNELEWEDDTPVATAKNMPGDSADLFGDGSAEDGSAANGRLWRTVIIGEQEHRIDLHMIRPYMKVVTHGGYYGEGLNAIIVFAACFLPDSSSPDYHYIMENLFLYVISSLELLVAEDYMIVYLNGATPRRRMPGIGWLKKCYHMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFISKIQYVHSLEELERLIPMEHVQLPDCVLQYEEQRLRAKRESTRPPQPEFLLPRSEEKPETVEEEDRAAEATEDQETSMS
Protein: Bidirectional sugar transporter SWEET13 (AtSWEET13) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 13) (Q9FGQ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane. Involved in nurturing the male gametophyte.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Glycosyltransferase
- Sucrose transport protein SUC2
Sequence:
MALTNNLWAFVFGILGNIISFVVFLAPVPTFVRICKKKSTEGFQSLPYVSALFSAMLWIYYAMQKDGTAFLLITINAFGCVIETIYIVLFVSYANKKTRISTLKVLGLLNFLGFAAIVLVCELLTKGSTREKVLGGICVGFSVSVFAAPLSIMRVVVRTRSVEFMPFSLSLFLTISAVTWLFYGLAIKDFYVALPNVLGAFLGAVQMILYIIFKYYKTPVAQKTDKSKDVSDHSIDIAKLTTVIPGAVLDSAVHQPPALHNVPETKIQLTEVKSQNMTDPKDQINKDVQKQSQV
Protein: Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1) (P56513)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (By similarity).
Subcellular location: Cell membrane, sarcolemma {ECO:0000269|PubMed:1710217, ECO:0000269|PubMed:9486665}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}.
Interaction partners:
- Protein kinase cAMP-activated catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- FXYD domain-containing ion transport regulator
- Sodium/potassium-transporting ATPase subunit alpha-1
- ATPase Na+/K+ transporting subunit alpha 3
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta
- Sodium/potassium-transporting ATPase subunit beta
Sequence:
MAPLHHILVLCVGFLTTATAEAPQEHDPFTYDYQSLRIGGLIIAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
Protein: Phytoene desaturase (lycopene-forming) (EC 1.3.99.31) (4-step phytoene desaturase) (Phytoene dehydrogenase) (P21685)
Organism: Pantoea ananas (Erwinia uredovora)
Function: Converts 15-cis-phytoene into all-trans-lycopene via the intermediary of all-trans-phytofluene, all-trans-zeta-carotene and all-trans-neurosporene, by the introduction of four double bonds.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1400305}.
Interaction partners:
Sequence:
MKPTTVIGAGFGGLALAIRLQAAGIPVLLLEQRDKPGGRAYVYEDQGFTFDAGPTVITDPSAIEELFALAGKQLKEYVELLPVTPFYRLCWESGKVFNYDNDQTRLEAQIQQFNPRDVEGYRQFLDYSRAVFKEGYLKLGTVPFLSFRDMLRAAPQLAKLQAWRSVYSKVASYIEDEHLRQAFSFHSLLVGGNPFATSSIYTLIHALEREWGVWFPRGGTGALVQGMIKLFQDLGGEVVLNARVSHMETTGNKIEAVHLEDGRRFLTQAVASNADVVHTYRDLLSQHPAAVKQSNKLQTKRMSNSLFVLYFGLNHHHDQLAHHTVCFGPRYRELIDEIFNHDGLAEDFSLYLHAPCVTDSSLAPEGCGSYYVLAPVPHLGTANLDWTVEGPKLRDRIFAYLEQHYMPGLRSQLVTHRMFTPFDFRDQLNAYHGSAFSVEPVLTQSAWFRPHNRDKTITNLYLVGAGTHPGAGIPGVIGSAKATAGLMLEDLI
Protein: Uncharacterized protein (Q387Z4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- NLE domain-containing protein
- Pescadillo homolog
- Ribosomal protein L1p/L10e family
- RNA-binding protein, putative
- Nucleolar GTP-binding protein 1
- Nucleolar complex protein 2
- Ribosome assembly factor mrt4
- rRNA processing protein, putative
- 60S ribosome subunit biogenesis protein NIP7 homolog
Sequence:
MSSLTSVQRRLLKYALEDKESKKLLKRKRAEDVAPALHQREKKRTCGHVCEADTTQDTEMTPLCPELLDFVRQKCPSAPRKLRKGQLHVINALSRGAVSGKDDDAINRCGARGAFSVKRLEMKDLPFAFSILGLAALQRRLLFDQKVKNGTSLLVLTEDEEDANSVALHLKETYRGVHVLVLDGSRFPSFPNIPNEEDNDGDATNNTFAERTVVLVSSLQAFLSSDGRSAIWKFVGAYVVILRELTNSTCVAMKGMKRMERQEFLKKLCEKRWLCLDHTPVAAVIAPARHALFTPLADALTISVPVAGEDAGEAKTVDKGEVRDSHDENQSKKKKGLPVDTLRDPVTVHYTVVEGQHRFHTLYALVMNARAGQGIVVHVATKEVCQFLYDVLHALGDLPPSLLLLTDYAGPSVHASVRDSDEDRQKVCDKFDDIVVNSDKSLAGSGKRDRVVLISSFGLVPQRGTVFVQYDIIVDIANFSQFVSDVLTPAAYANLAASQLPRLGGRAAPGVTSARRSRSVSPSKSVSPPRPTQVRAMYRHVLLLLRKNELQGALEHFNRSANRLHITYKPMKQMPSATRFLLAVQKLQSLNKKQFAVQNAAYAAYRATMLLYSVISSSKEVYDERNVDLKLVAQEFGYSDAPIVDLRTRDTAFRPKENIFRAACKRAARDRRLLLRPPAEEGSPEVSQPQREENQ
Protein: L-tyrosine decarboxylase (TDC) (EC 4.1.1.25) (J7GQ11)
Organism: Levilactobacillus brevis (Lactobacillus brevis)
Function: Catalyzes the decarboxylation of L-tyrosine to produce tyramine. Cannot use other aromatic L-amino acids as substrates like L-phenylalanine, L-tryptophan and L-glutamate.
Interaction partners:
Sequence:
MEKSNRSLKDLDLNALFIGDKAENGQLYKDLLNKLVDEHLGWRKNYIPSDPNMIGPEDQNSPAFKKTVGHMKTVLDQLSERIRTESVPWHSAGRYWGHMNSETLMPALLAYNYAMLWNGNNVAYESSPATSQMEEEVGQEFARLMGYDYGWGHIVADGSLANLEGLWYARNIKSLPFAMKEVNPELVAGKSDWELLNMPTKEIMDLLENAGSQIDEVKKRSARSGKNLQRLGKWLVPQTKHYSWMKAADIIGIGLDQVVPVPIDSNYRMDIQALESIIRKYAAEKTPILGVVGVAGSTEEGAVDGIDKIVALRQKLQKEGIYFYLHVDAAYGGYARALFLDEDDQFIPYKNLQKVHAENHVFTEDKEYIKPEVYAAYKAFDQAESITIDPHKMGYVPYSAGGIVIQDIRMRDTISYFATYVFEKGADIPALLGAYILEGSKAGATAASVWAAHHTLPLNVTGYGKLEGASIEGAHRYYDFLKNLKFEVAGKRISVHPLISPDFNMVDYVLKEDGNDDLIEMNRLNHAFYEQASYVKGSLYGKEYIVSHTDFAIPDYGDSPLAFVESLGFSEVEWRHAGKVTIIRASVMTPYMNQRENFDYFAPRIKKAIQADLEKVYASVNQKENV
Protein: ABC transporter C family member 9 (ABC transporter ABCC.9) (Q54NL1)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
Sequence:
MIRNKIKNKKSKSDYYSEISLEEEEDKEEEIKDKKVLSKEEIKENENKNEKIKQTQCPEDNASLFSKITFGWITKLIVKAYIKKSLDIKDIFDVPNYLKSNYTSKFLTTEKQTFKRNTKYSLILNIYINFILLKNKKLILIQFLRVLFTLLSPLILKLFIEFTQRIDSEKSIIEGIIYCGLLFFSSFCSSLVDEYLVWFGMITSSQVKSCLTCLIFEKSLKLSNSAKVKYNAAKITNLISIDVDNFSNFFWSNSVEIFFQPFQLIFLLILLISEVGWSGFVGTAVILISFPINSYFGKKTSDYYEKLLKYTDKRVSTTSEFINGIRFIKMYAWESLFLKKIEKQRKQELKILLERGLFWLGQIIIINTNSTFVFVATMVTYSLSGNKMKLETAFTAMNILDSIRILLIVMPYCYYSIMELIPSNKRIEKFLSTLEIQQNLQTTKNSNTISINNGTFKWKDENFEETDDDDDHDDDDDEGEKEIEGKEEKEEINNFIFENINFKAPIGKLTMICSPVGSGKTSLINALIGEIEKVNGEINGVPENISFTSQQPFLLSTSLRENILFGKELDIEYYKQVLDACCLVSDLTQLSALDLTEIGEGGINLSGGQKQRVSLARALYSNSDFILMDEPLSAVDPEVANHLFEKCIQGMMKNKTRILVTHQIQFIPYADHIVIIKDGKIIQGTYKELKDENGIDFESIIKTKNSNLNLNKTIKDEEEKEDKEGEEKEEDKKEMILKLIKINYSDELKEKAKLLVEEDRNEGEVSFKTYKEYFYYGSSNLFLFITLLVFLIGLIVNRLSDFWLTIWTEQSFKEKSQTFYIICFVSIFIVSLILIFIRYSLVAKIGFKSSKKLHDLLINSISKSPIQFFDSNPSGRILNRFSNDISDIDTSMIDMFSDTLEYIFAIVVGIFSIIYINPMTIVPFLILSMFYYQIFNIYRVSVRELNRCKSISQSPIISFLSECCNGLSTIRAFKQQSRFIGIMNDNIDKNLKCEFASFAVEMWISIRLELLSSIIVFIVSLFSLFNGYSNSALSILSVSTARSITSYLKSACRQMVDLERKMNSFERVNNYIKLPSEGSGSGVKSMEFISEKDLLNWPEKGNIQFNNVQVNYNSNSVPSLKDITFSVESNEKIGIVGRTGAGKSTIANCLFRLVECSKGSILIDGIDIKTIDLNKLRGSLGIVPQEPWLFSGTIRSNIDPLNQYDDEMIWNYLEMVKLKKLIIEMPLKLNSKIHENGNTTLSYGQKQLLCLCRCLIKNPKLIIMDEATSSVDFQTAETIKSVINENLVNNTILTIAHRLDIIIDSDKIAVIDNSKLIEFENPKNLINSNSKFRKIVNFQTKIQTN
Protein: Brevinin-2Rk (C0HL04)
Organism: Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
Function: Antimicrobial peptide.
Subcellular location: Secreted {ECO:0000269|PubMed:28012108}.
Interaction partners:
Sequence:
GLWKTLKDSAKSAVTNVAVTMLDKLRCKLTGGC
Protein: RNA binding motif protein 14 isoform 1 (A0A0S2Z4Z0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRENAGALRAIEALHGHELRPGRALVVEMSRPRPLNTWKIFVGNVSAACTSQELRSLFERRGRVIECDVVKDYAFVHMEKEADAKAAIAQLNGKEVKGKRINVELSTKGQKKGPGLAVQSGDKTKKPGAGDTAFPGTGGFSATFDYQQAFGNSTGGFDGQARQPTPPFFGRDRSPLRRSPPRASYVAPLTAQPATYRAQPSVSLGAAYRAQPSASLGVGYRTQPMTAQAASYRAQPSVSLGAPYRGQLASPSSQSAAASSLGPYGGAQPSASALSSYGGQAAAASSLNSYGAQGSSLASYGNQPSSYGAQAASSYGVRAAASSYNTQGAASSLGSYGAQAASYGAQSAASSLAYGAQAASYNAQPSASYNAQSAPYAAQQAASYSSQPAAYVAQPATAAAYASQPAAYAAQATTPMAGSYGAQPVVQTQLNSYGAQASMGLSGSYGAQSAAAATGSYGAAAAYGAQPSATLAAPYRTQSSASLAASYAAQQHPQAAASYRGQPGNAYDGAGQPSAAYLSMSQGAVANANSTPPPYERTRLSPPRASYDDPYKKAVAMSKRYGSDRRLAELSDYRRLSESQLSFRRSPTKSSLDYRRLPDAHSDYARYSGSYNDYLRAAQMHSGYQRRM
Protein: Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease) (Q5U405)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9BYE2}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:Q9BYE2}. Cytoplasm {ECO:0000250|UniProtKB:Q9BYE2}. Note=The non-phosphorylated, inactive full length protein localizes intracellularly (By similarity). N-glycosylation and phosphorylation is required for trafficking to the cell surface (By similarity). Interaction with SPINT1/HAI-1 and SPINT2/HAI-2 facilitate its translocation to the cell surface (By similarity). Proteolytic cleavage is required for secretion (By similarity). {ECO:0000250|UniProtKB:Q9BYE2}.
Interaction partners:
Sequence:
MDRGSHRNSSPARTPPQASPARTSPARAPPQASPARTPPQASPARTPPQASPARAPPPQASPARASPARAPPSRSSSGRSSSARSASTTSSPTRVYLVRATPVGAVPIRASPARSAPATRATRESPGLSFPKFSWQETQRQLPLIGCVILLISLVISLILLFYFWRGHTGIKYKEPLESCPIHAVRCDGVVDCKMKSDELGCVRFDWDKSLLKVYSGSSGEWLPVCSSSWNDTDSKRTCQQLGFDSAYRTTEVAHRDITSSFLLSEYNTTIQESLYRSQCSSRRYVSLQCSHCGLRAMTGRIVGGALTSESKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKLLEGWKVYAGTSNLHQLPEAASISQIIINGNYTDEQDDYDIALIRLSKPLTLSAHIHPACLPMHGQTFGLNETCWITGFGKTKETDEKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWIYRKMESEVRFRKS
Protein: Cytoplasmic trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) (P62601)
Organism: Escherichia coli (strain K12)
Function: Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01059, ECO:0000269|PubMed:10816581}.
Interaction partners:
- Trehalose-6-phosphate phosphatase
- Trehalose-6-phosphate hydrolase
- Periplasmic trehalase
- Trehalose-6-phosphate synthase
Sequence:
MLNQKIQNPNPDELMIEVDLCYELDPYELKLDEMIEAEPEPEMIEGLPASDALTPADRYLELFEHVQSAKIFPDSKTFPDCAPKMDPLDILIRYRKVRRHRDFDLRKFVENHFWLPEVYSSEYVSDPQNSLKEHIDQLWPVLTREPQDHIPWSSLLALPQSYIVPGGRFSETYYWDSYFTMLGLAESGREDLLKCMADNFAWMIENYGHIPNGNRTYYLSRSQPPVFALMVELFEEDGVRGARRYLDHLKMEYAFWMDGAESLIPNQAYRHVVRMPDGSLLNRYWDDRDTPRDESWLEDVETAKHSGRPPNEVYRDLRAGAASGWDYSSRWLRDTGRLASIRTTQFIPIDLNAFLFKLESAIANISALKGEKETEALFRQKASARRDAVNRYLWDDENGIYRDYDWRREQLALFSAAAIVPLYVGMANHEQADRLANAVRSRLLTPGGILASEYETGEQWDKPNGWAPLQWMAIQGFKMYGDDLLGDEIARSWLKTVNQFYLEQHKLIEKYHIADGVPREGGGGEYPLQDGFGWTNGVVRRLIGLYGEP