wanglab/gogpt-training-data huggingface dataset:
Protein: SNF1-related protein kinase regulatory subunit gamma-1 (AKIN subunit gamma-1) (AKING1) (AKINgamma1) (CBS domain-containing protein CBSCBS1) (Q8LBB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulatory subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:30511331}.
Interaction partners:
- SNF1-related protein kinase regulatory subunit beta-1
- SNF1-related protein kinase regulatory subunit beta-3
- SNF1-related protein kinase regulatory subunit beta-2
- CBS domain-containing protein CBSCBSPB3
- CBL-interacting serine/threonine-protein kinase 10
- SNF1-related protein kinase regulatory subunit gamma-like PV42a
- CBS domain-containing protein CBSX5
- Sucrose nonfermenting 4-like protein
- Phosphoglucan phosphatase LSF1, chloroplastic
- CBS domain-containing protein CBSX6
Sequence:
MATVPEIKIMRSESLGHRSDVSSPEAKLGMRVEDLWDEQKPQLSPNEKLNACFESIPVSAFPLSSDSQDIEIRSDTSLAEAVQTLSKFKVLSAPVVDVDAPEDASWIDRYIGIVEFPGIVVWLLHQLEPPSPRSPAVAASNGFSHDFTTDVLDNGDSAVTSGNFFEVLTSSELYKNTKVRDISGTFRWAPFLALQKENSFLTMLLLLSKYKMKSIPVVDLGVAKIENIITQSGVIHMLAECAGLLWFEDWGIKTLSEVGLPIMSKDHIIKIYEDEPVLQAFKLMRRKRIGGIPVIERNSEKPVGNISLRDVQFLLTAPEIYHDYRSITTKNFLVSVREHLEKCGDTSAPIMSGVIACTKNHTLKELILMLDAEKIHRIYVVDDFGNLEGLITLRDIIARLVHEPSGYFGDFFDGVMPLPENYRV
Protein: Protein odd-skipped-related 1 (Q8TAX0)
Organism: Homo sapiens (Human)
Function: Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGSKTLPAPVPIHPSLQLTNYSFLQAVNGLPTVPSDHLPNLYGFSALHAVHLHQWTLGYPAMHLPRSSFSKVPGTVSSLVDARFQLPAFPWFPHVIQPKPEITAGGSVPALKTKPRFDFANLALAATQEDPAKLGRGEGPGSPAGGLGALLDVTKLSPEKKPTRGRLPSKTKKEFVCKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHSQVKELKTSKIKC
Protein: Ephrin-B2a (O73874)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P52799}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Ephrin type-B receptor 4a
- Ephrin type-A receptor 4a
- Eph receptor B2a.
- Eph receptor A4b.
- EPH receptor B1.
- Ephrin-A5b
- Receptor protein-tyrosine kinase.
- Vascular endothelial growth factor receptor 3
- Delta-like protein
- Hairy/enhancer-of-split related with YRPW motif protein 2
Sequence:
MGDSLWRYYFGVLVIACKVNLSRALILDSIYWNTTNTKFVPGQGLVLYPQIGDKMDIVCPRVEGGSMEGVEYYKLYMVPLEQLKSCQVTKADTPLLNCVKPDQDVKFTLKFQEFSPNLWGLEFFRGKDYYIISTSNGTMEGLDNQEGGVCKTKSMKIIMKVGQNPSDPISPKDYPTSYPPKHPDLGGKDSKSNEVLKPDASPHGEDKGDGNKSSSVIGSEVALFACIASASVIVIIIIIMLVFLLLKYRRRHRKHSPQHATTLSLSTLATPKRGGSGGNNNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
Protein: Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6) (G3V4A5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR023869}.
Interaction partners:
Sequence:
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPEKRMRLQKAV
Protein: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC (EC 3.1.3.45) (KDO 8-P phosphatase) (P0ABZ4)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
Interaction partners:
- 3-deoxy-manno-octulosonate cytidylyltransferase
- Arabinose 5-phosphate isomerase KdsD
- 2-dehydro-3-deoxyphosphooctonate aldolase
- Inner membrane protein YrbG
- Lipopolysaccharide export system protein LptC
- Lipopolysaccharide export system ATP-binding protein LptB
- Arabinose 5-phosphate isomerase GutQ
- Lipopolysaccharide export system protein LptA
- Tetraacyldisaccharide 4'-kinase
- 3-deoxy-D-manno-octulosonic acid transferase
Sequence:
MSKAGASLATCYGPVSADVIAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSDIEVAIITGRKAKLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIAGGRGAVREVCDLLLLAQGKLDEAKGQSI
Protein: Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Glycoprotein 210 kDa) (Nuclear pore membrane glycoprotein gp188) (Nucleoporin Nup210) (Nup210) (A1Z6H7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the nuclear pore complex.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:2517292, ECO:0000269|PubMed:3919018}; Single-pass type I membrane protein {ECO:0000255}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:17682050, ECO:0000269|PubMed:7641726}. Cytoplasm {ECO:0000269|PubMed:2517292}. Note=During mitosis diffusively localized throughout the cytoplasm. {ECO:0000269|PubMed:2517292}.
Interaction partners:
- Nuclear pore complex protein Nup98-Nup96
- Nuclear pore complex protein Nup154
- Nucleoporin Nup35
- Nuclear pore complex protein Nup107
- Nuclear pore protein
- Nuclear pore complex protein Nup205
- Nucleoporin Nup188
- Nuclear pore complex protein Nup214
- Nuclear pore complex protein Nup160 homolog
- Nuclear pore complex protein Nup133
Sequence:
MDSILCMILLILVRNHASEAARLNHPRVLLPIFEDKAINFTLEVDEPNCYKWSSSRQDLISVMPIYKGFSECAYQAVVTVRTHDRRRNTAIVFAEEVQTGETLRSDVIVDVIASLNVRTATRQLYLEEAPAMFELHAFDEQGNEFFTLEGIEFDWEILEPGSKRPTAMRYLTFTDSPYHTVPPTIEKFEADGKKGHMILLEGINTGTAKVTIAMPQAEYKHVRPVEVYISVLANIIIEPSEVTIMAGDSVSFRILQLKMDRLHVIDNNQYYLEVEDSSIAYLRGNSATGAALGRTQVFLRDRNMADSDEVQKGPSALLTVAYPNRLSISLLPHLNWVTVQGEHHAIALDLFAADGQKITMGTKYSINSEVDESFFAIVDRTRNGSRLFGQAKKEGITQVYGSYKDLSVQAELQIFEELQLAPTKVVLPYDPNSLKPLKLQFHASGGDNNYAWFSGNPQVIQIDTQGQATTEIRDVKSAYVNQEVLKDGGKLTAHTTVKVALSKNQKISRVAHIYFLPPERLQITRSNFETALKDFVHVHVGVYARINNSEVPYTSCDNLHFQLDFSQPILQLEGNEGAEAAHEACHVLRLRATAVGTTSLRVSYMYMDKVLYDIIDLYVFEPLVVLNPIENEVVLPVGSSRNIIYANGPQRSFTVAAEIIQSTAFDEKILKVSKLEFDTQNLITAFTVLCRELGETQFTYRVHNSLPTSSFALYQSEVTTKVHCVRPRFLKLYARHNLRDSCPLEKRTSLLFLKDPENKIEIEIEVHDSNNRRLMNISSLGLDWEFSAGEERYQKNIIPHRQISELEFNHGVTLPSRDLLVLTLSEVATNFRIKGTVSQYNDKLLAQHGIHAERPPFGIKNPQTGLIYTPLIENEIRLHAVNSTLLPKDYMSIFLASGYSERIPIAQGSGYLQLELSEAGIVQVEYNENTRILVLTPLRLGHVRLELTDRCLMNEPSHLSISVVGIGAIEVVSMDRLERTTRIEAIVRLFDTNDNLLLVDQSKLSAYDLSEVVADQSILSVRLGEQENVGPGEIRYTITGNQVGETKILFQSGKGIYKVASDPLNIQVFAPIRLFPRDSTLVVGSSIQVYFHGGPHPNTNMIISVEKEQVATISSTVVTAHKLGTTKIVGKCLLKNPVTGKDEVVSQDSVEVHVVALKGVQIRTPLVRIHSGAVMPATLWGLSDLSPMILGTLQNTKISWKVSQPQVVEIFNVFTTAGIEYQSGDLISVRVRALNPGKATITASVTLADGTILPPATVDLQVFKTLELVTPNAIKMDSILAAPRSILQLKSNMDNVVYKLDDRSNGIVSVTPDGLVHTKDSLGRDLIIATTADQSLPIGIEVKNVQYILVTLMPILKLRELEHKIPRGMNFVFKVSLHDNLGNELSHNIEDFNGLRYELGNKDDVDVQIDNNLTFALNLMRETNNVIGISLKDSTGVKHSMDFIKLSVVESDNLFPTKTIFSVGDIICFDSPLTLSSTWRSSNEQIVYINKHTGIAQVLSHRLKPGEKIEITNGDETKRGGFLKYDLEVRESDTILFVKSVDTFSGPEYRGQLVIRNHLQSEKYSNLIAQNVSKCARELGSVPVNFFTCRLAAKDALGRNLLKMYKVDALFEPSIGQYSCRLQLLTGFIELLSIVKTHDVYLELEAVVAKGVSDKMSLKLVPGIKVFPESVRVTDLKPHEIHISGLDKALLKVQVKPSDSKYFAVDFIEHGHGLSKYRLELFDDLPLDENFYILVVSPDTKQSIEVPIIGNTMLAPKCTDRRYGGPLVYRILENLGFVLTTTVIVIISIWVYMSCFQTQGVTQVNFEAFKKGKSRTELMQQSGRSSQDDTFGDSFNVRNFSPDRRRPPSNALSESYIYGHPRLNSSNRSENSTSFS
Protein: Probable pectate lyase 22 (EC 4.2.2.2) (Q93Z25)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable pectinesterase/pectinesterase inhibitor 44
- Pectin lyase-like superfamily protein
- Probable pectinesterase/pectinesterase inhibitor 54
- Pectin lyase-like superfamily protein
- Expansin-A8
Sequence:
MFRPNSLLIPSNLSTTKSQRNTMLNSSYLSFALIFFCCILFSALASSLPVSDPELVVEEVHRKINESISRRKLGFFSCGSGNPIDDCWRCDKDWEKNRKRLADCGIGFGKNAIGGRDGEIYVVTDPGNDDPVNPRPGTLRYAVIQDEPLWIIFKRDMTIQLKEELIMNSFKTLDGRGASVHISGGPCITIQYVTNIIIHGLHIHDCKQGGNTYVRDSPEHYGYRTVSDGDGVSIFGGSHVWVDHCSLSNCNDGLIDAIRGSTAITISNNYLTHHNKVMLLGHSDTYEQDKNMQVTIAFNHFGEGLVQRMPRCRHGYFHVVNNDYTHWEMYAIGGSANPTINSQGNRFLAPDDSSSKEVTKHEDAPEDEWRNWNWRSEGDLLLNGAFFTYSGAGPAKSSSYSKASSLAARPSSHVGEITIASGALSCKRGSHC
Protein: Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) (P51608)
Organism: Homo sapiens (Human)
Function: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Z2D6}. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. {ECO:0000269|PubMed:28348241}.
Interaction partners:
- Histone deacetylase 1
- Paired amphipathic helix protein Sin3a
- DNA
- Nuclear receptor corepressor 1
- Histone deacetylase 2
- Cyclic AMP-responsive element-binding protein 1
- REST corepressor 1
- Histone-lysine N-methyltransferase SUV39H1
- Transcriptional regulator ATRX
- Y-box-binding protein 1
Sequence:
MVAGMLGLREEKSEDQDLQGLKDKPLKFKKVKKDKKEEKEGKHEPVQPSAHHSAEPAEAGKAETSEGSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTTRPKAATSEGVQVKRVLEKSPGKLLVKMPFQTSPGGKAEGGGATTSTQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHSESPKAPVPLLPPLPPPPPEPESSEDPTSPPEPQDLSSSVCKEEKMPRGGSLESDGCPKEPAKTQPAVATAATAAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS
Protein: At2g35830/F11F19.26 (Expressed protein) (Ureidoglycolate hydrolase) (Q9SJ67)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAKSPVEVNLIPIEATPENFAEYGQVIEASRDGAGFGPHDAQLDLSRGTPRLYILRLKETPLGFFKITHHAKVTQCLGSIGGDVWYMGVAKPSLIEDDDDDGRSVDTVKSKSGHLYIPPEVEEIRVFRFSGPKFVKLHRGTWHAGPLFSGSSFMDFYNLELSNTNVVDHTSHDFTKNNGVSFGFDTLSS
Protein: Leptin (Obesity factor) (Q95MZ8)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRCGPLYRFLWLWPYLSYVESVPIRKVQDDTKTLIKTIVTRINDISHT
Protein: Histone acetyltransferase SAS2 (EC 2.3.1.48) (Something about silencing protein 2) (P40963)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Histone acetyltransferase (HAT) subunit of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing and G0 control.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Something about silencing protein 5
- Something about silencing protein 4
- Histone H4
- Enhancer of polycomb-like protein 1
- Chromatin modification-related protein EAF3
- SWR1-complex protein 4
- Chromatin modification-related protein YNG2
- NAD-dependent histone deacetylase SIR2
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
- Chromatin modification-related protein EAF6
Sequence:
MARSLSQSLTATTQKLKGKKNGGKGKNKPSAKIKKTQKEMLYGILNERNIRQIQFGLNKKFSTWYGSAVYFDPETKRLGCSETKGQLSSVSNSQYWLDTLFVCEYCFKYTDDQTRFVGHVASCPFQYRVPGKIKYKSPEYTIRRVKGSKYQLFCQCLCLFTKLYLDNKSMYFKVDHYEFYIVYETGSTKPMGFFSKDLVSYQQNNLACILIFPPYQRRGLGLLLIEFSYKLSQLEGVISGPEVPLSPFGLIGYLKYWSQILCWHLIEGDLAHYDKVTLEDLSIVTGMRVNDVILTLKHLNCIGENNQIYLQSLNSWLKLHGTKRNWFKLKDEYLLIDD
Protein: Probable E3 ubiquitin-protein ligase rnf113 (EC 2.3.2.27) (RING finger protein 113 homolog) (O17917)
Organism: Caenorhabditis elegans
Function: May function as E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. May play a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit proteins involved in repair to sites of DNA damage by alkylating agents.
Interaction partners:
- Cell division cycle 5-like protein
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Pre-mRNA-processing factor 19
- Spliceosome-associated protein CWC27 homolog
- PSP proline-rich domain-containing protein
- BUD13 homolog
- Pre-mRNA-splicing factor CWC22 homolog
- Splicing factor 3A subunit 2
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4
- Spliceosome-associated protein CWC15 homolog
Sequence:
MDLFRKPKKRNAPVVRKKESSSDEDQDSEVKDVIQKRRRTNPMVQSTKQLDASTRRADNSSDDSDDSDDNQDIAVATHSFAASGDAGPSGPRDQGATATLEVDTDYSHDAQAQFERVQQQLKEGVEKDGKILYKGSALYGAKEAKDTAKGNAASGYNRVGPVRAPQFLRQTVRWDFAPDICKDYKETGFCTFGDSCKFVHDRSDYKHGWEIDEEYEAGKYGAEDDANYEIHEGDDTFPEDCFICGNPFVDPIVTKCKHYFCTGCALKSFQKSSKCPICQQNTENIMNTAKELLTYLKRKKQQQKQEAEKQEEEKDSDDDEKPHECDDHHHHDHEDEPEEPENDSNVPEAEEKSDEEQEIMMEDVEGLEGGENDSESDDDDAEKD
Protein: GATA transcription factor 2 (AtGATA-2) (O49741)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein BRASSINAZOLE-RESISTANT 1
- E3 ubiquitin-protein ligase COP1
- B-box zinc finger protein 20
- Transcription factor HY5
- Transcription factor LAF1
- Calcium-binding EF-hand family protein
- GATA transcription factor 24
- Transcription factor HFR1
Sequence:
MDVYGLSSPDLLRIDDLLDFSNEDIFSASSSGGSTAATSSSSFPPPQNPSFHHHHLPSSADHHSFLHDICVPSDDAAHLEWLSQFVDDSFADFPANPLGGTMTSVKTETSFPGKPRSKRSRAPAPFAGTWSPMPLESEHQQLHSAAKFKPKKEQSGGGGGGGGRHQSSSSETTEGGGMRRCTHCASEKTPQWRTGPLGPKTLCNACGVRFKSGRLVPEYRPASSPTFVLTQHSNSHRKVMELRRQKEVMRQPQQVQLHHHHHPF
Protein: Naringenin-chalcone synthase (EC 2.3.1.74) (Q8RVK9)
Organism: Cannabis sativa (Hemp) (Marijuana)
Function: Chalcone synthase that can also use isovaleryl-CoA, isobutyryl-CoA or hexanoyl-CoA as substrates, but that is unable to produce olivetol or olivetolic acid.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MVTVEEFRKAQRAEGPATIMAIGTATPANCVLQSEYPDYYFRITNSEHKTELKEKFKRMCDKSMIRKRYMHLTEEILKENPNLCAYEAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPNDTHLDSLVGQALFGDGSAALIVGSDPIPEVEKPIFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPLGISDWNSLFWIAHPGGPAILDQVESKLALKTEKLRATRHVLSEYGNMSSACVLFILDEMRRKCVEDGLNTTGEGLEWGVLFGFGPGLTVETVVLHSVAI
Protein: Large ribosomal subunit protein eL33 (60S ribosomal protein L35a) (A0A8L2QNQ0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSGRLWCKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRISTNGE
Protein: Myosin VB (Unconventional myosin-Vb) (F1QKS0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MREHELYVKYTRVWIPDPDEVWRSAEIIKDYKEGDTVLHLKLEDESTLEYPIGSKDNPLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLHIYGEEVINAYSGQNMGDMDPHIFAVAEEAFKQMARDEKNQSIIVSGESGAGKTVSAKYAMRFFATVGGSANDTNVEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDRRYHIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASCSLPEFKDLTLTSAEDFTYTSLGENIFIEGVNDAEDLVKTREALTMLGVKENHQMSIFKIIASILHLGNVEIVQERDGESCHINRNDTHLHHFCRLLGIEQEQMENWLCRRKLVTTSETYVKNMPHSQAVNARDALAKHIYAHLFDWIVEHINKSLHTSTKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYSKHSGSGHFEKPRMSNKSFIVVHFADKVEYQCDGFLEKNRDTVYEEQINILKASKFQLVADLFDDAKDAAPHPGSKTSRINVRPAKPAPKGHNREHRKTVGTQFRNSLHLLMETLNATTPHYVRCIKPNDYKESFVFDSRRAVQQLRACGVLETIRISAAGYPSRWTYPDFFSRYRVLMTKKDLSVGDKKQVCKNLLEILIKDPDKFQFGKTKIFFRAGQVAYLEKLRADKFRFACIKIQKTVRGWLQRIRYRKIRKSAITLQRYGRGYLARRYAEMLRLTRAAVICQKQYRMVQVRREYLRVRRAVITIQAFTRGMFIRRLYQEFLLHHKAMIIQKTVRGWLVRKKYQRSRYAAIVIQCFYRRVRAKRQLKQLKIEARSAEHFKKLNVGMENKIVQLQKKMDNQSKELKSQNENLAVAKTVLETEVSKLSKELETLRTRQVAGTQMTSLQEELEKLRAELQEAHAHKKLLEEEFSNEKQGLEQRVEELEKENTVLKKEKEEMNRRIQTSTQDQGGDVSQKESRLQHELDDERQRYQNLVKEYSRLEQRYENLQEDMSSMKFHPGHRRNPSNQSSLGSDSNYPSISLSEVGDTDDTIQQVEEMGIEKAAMDLSVFMKLQKRVRELEQERKRLQTNLDKVEELSKRKGSEAKNSTSEDDINADLAYNSLKRQELETENKKLKNDLNELRKAVADRASENNSSNELQDGYNLLLSQLKAANEELDVRKEEVLMLKTQIVNSTRQTENLNHINSNDVSEWTDNKSPVNTEDRVDAPASKNKAQDWGYLNEDGELGLAYQGLKQVARLLETQLQTQTRQHRDELEALHTQIELLKDNLEKKQDMLDHFSTLSPDALVEFSVQQEITRLTNENLDLKELVEKLEKNEKKLKKQLRIYMKKVQELEVTQATKSRPELTRQFTVQRREKDFEGMLEYYKEDEALLVKTLVTDMKPNAVSATVPCLPAYILFMCIRHADYINDDQKVHSLLTATINAIKKVLKKNNDDFEMTSFWLANASRLLHCLKQYSGDEAFMTQNSAKQNEHCLKNFDLAEYRQVLSDLSIQIYQQLVKVAEANMQPMIVSAMLESESIPSLAGVKPMGYRNRSSSVDCESGGPAGYTLQALIKQLAQFYSTMADHGLDPEISQQVLRQLFYSINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGKNLHQCGAVATMEPVIQAAQLLQVKKKTSQDAEAICSLCTALSLQQIVKILNLYTPLNEFEERVTVSFIRDIQNRLQDRIENNQLLADTKYTFPVLFPYTPSNLSLETIHIPASLSLDFLTRV
Protein: Protein POLR1D, isoform 2 (P0DPB5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEEDQELERKAIEELLKEAKRGKTRAETMGPMGWMKCPLASTNKRFLINTIKNTLPSHKEQDHEQKEGDKEPAKSQAQKEENPKKHRSHPYKHSFRARGSASYSPPRKRSSQDKYEKRSNRR
Protein: Tubulin polymerization-promoting protein family member 2 (Protein p25-beta) (TPPP/p18) (P59282)
Organism: Homo sapiens (Human)
Function: Probable regulator of microtubule dynamics required for sperm motility (Probable). In contrast to other members of the family, has no microtubule bundling activity.
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:17105200}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q0P5Y3}. Note=Present in the middle piece of sperm tail. {ECO:0000250|UniProtKB:Q0P5Y3}.
Interaction partners:
Sequence:
MASEAEKTFHRFAAFGESSSSGTEMNNKNFSKLCKDCGIMDGKTVTSTDVDIVFSKVKAKNARTITFQQFKEAVKELGQKRFKGKSPDEVLENIYGLMEGKDPATTGATKATTVGAVDRLTDTSKYTGTHKERFDESGKGKGIAGREEMTDNTGYVSGYKGSGTYDKKTK
Protein: Suppressor of cytokine signaling 1 (Q4JHT5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI
Protein: D-arabinono-1,4-lactone oxidase (ALO) (EC 1.1.3.37) (L-galactono-gamma-lactone oxidase) (Q9HDX8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion membrane {ECO:0000250}. Note=Membrane-embedded. {ECO:0000250}.
Interaction partners:
- Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
- tRNA-dihydrouridine
- Myo-inositol transporter 1
- Very-long-chain 3-oxoacyl-CoA reductase
- Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase
- Probable electron transfer flavoprotein subunit alpha, mitochondrial
Sequence:
MSIPHINKLSQDGRVRFSNWAKTFSAISLGLRCPKTEEQLREILVDANSNGKKIRVVGAGHSPSDIVCTSGYLLSLDKMNKVVSFDPDSLSITVQAGIRFYQVQEILQNLGYSLPIVGSISETSVSGIMSTCTHGSSLQHQVLPHYIKSMRIMLADGSIVTCSRELQKDMFAAAQVSLGALGVIVDITISVVPAFDLVATEDVTTVTDLFQDWKNNLIWESAEFVRVHVFPYANRAVVWRANKVEPNTVPHTPKPSLFRLKLDSFVYQCLLFVGKCVNRVTPYLERFWFKCHYGSKLGTALQVAGPGFDVLQMFCYFSQHVSEWGIPLESAPDALEKLINYTVDDAGKIGAYTHWPIEVRVCAPTPEDECWLSTDCKVPTCYIEAIMYRPFSTSINYKPYFKALEDIANQYNGKPHWAKEYSLTKEQLLERYPNLSKWLSLRKLLDPKGVFWNDYLQRHLG
Protein: SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) (P29353)
Organism: Homo sapiens (Human)
Function: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Subcellular location: Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:35687021}.; SUBCELLULAR LOCATION: [Isoform p46Shc]: Mitochondrion matrix {ECO:0000269|PubMed:14573619}. Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.; SUBCELLULAR LOCATION: [Isoform p66Shc]: Mitochondrion {ECO:0000250}. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. {ECO:0000250}.
Interaction partners:
- Insulin-like growth factor 1 receptor
- Growth factor receptor-bound protein 2
- Son of sevenless homolog 2
- Receptor tyrosine-protein kinase erbB-3
- Son of sevenless homolog 1
- Proto-oncogene tyrosine-protein kinase Src
- BDNF/NT-3 growth factors receptor
- Receptor tyrosine-protein kinase erbB-4
- Epidermal growth factor receptor
- Receptor tyrosine-protein kinase erbB-2
Sequence:
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Protein: Rhodanese-like domain protein (Q72CB5)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Thioredoxin family protein
- Succinate--CoA ligase subunit alpha
- CBS domain protein
- Superoxide dismutase
- RNA polymerase sigma factor SigA
- ABC transporter, ATP-binding protein/permease protein
- Acyl carrier protein, putative
- Acyl carrier protein
- Large ribosomal subunit protein uL13
- Endoribonuclease YbeY
Sequence:
MRRVIIVGSSLAAAKVATRLKRKDPSSEVNIIVPAVESGQESVKDGVFYKARAERHAVAELLRSREVGVVEASDLSVDFDARVVLPTSSRGSLPIRYNVLVLEVQAQPRIPRVLRGAPNVIGWPGEGAATLDAMLSTTAEVRVVVVGQGQAAMEALRLVARSGQVPVWLRLGDVGPDILDGDTWRMVERLAANGGVEVHDWSHVPMERMGARPDEHGGVAALVAALEGGNDLRVEGDVFIWTAPTVVQHPVVAQEGITLDAHGRIEVDGNLATVEEGVYLIGTGVAMACGCGSAPLHVGEHDLAGLARGLADHLAGDATTTMPPCTGLVHAEGPGFAVSRAGVTLEEAVRRGLEGEFALLPLEDGGLLKLVADKVSRQVIGYQATGTGESLDLLAPLLSFAVGRSATVDELAASDCPGPVGTVVRKVAGILANKMEGRFYGITADELRASREAGAEFFLLDLRAMPEWRNGHIPGAYNIPLPQLAKRLQDEVPRFTPIVLVSRTSDAAWSVACKLFGLGATALYVLDGGMRCWDYELETA