wanglab/gogpt-training-data huggingface dataset:
Protein: Sensory neuron membrane protein 1 (SNMP1Dmel) (Q9VDD3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an olfactory role that is not restricted to pheromone sensitivity. Has a role in detection and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Not required for sensitivity to general odorants. Acts in concert with Or67d and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Essential for the electrophysiological responses of these olfactory sensory neurons (OSNs) to cVA. Not required for the development of trichoid OSNs and support cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O02351}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O02351}.
Interaction partners:
- General odorant-binding protein lush
- Ionotropic receptor 25a
- IP01303p
- Ionotropic receptor 8a
- Glycine--tRNA ligase
- Putative odorant receptor 83c
- Odorant receptor 67d
- Odorant receptor coreceptor
Sequence:
MQVPRVKLLMGSGAMFVFAIIYGWVIFPKILKFMISKQVTLKPGSDVRELWSNTPFPLHFYIYVFNVTNPDEVSEGAKPRLQEVGPFVFDEWKDKYDLEDDVVEDTVSFTMRNTFIFNPKESLPLTGEEEIILPHPIMLPGGISVQREKAAMMELVSKGLSIVFPDAKAFLKAKFMDLFFRGINVDCSSEEFSAKALCTVFYTGEIKQAKQVNQTHFLFSFMGQANHSDSGRFTVCRGVKNNKKLGKVVKFADEPEQDIWPDGECNTFVGTDSTVFAPGLKKEDGLWAFTPDLCRSLGAYYQHKSSYHGMPSMRYTLDLGDIRADEKLHCFCEDPEDLDTCPPKGTMNLAACVGGPLMASMPHFYLGDPKLVADVDGLNPNEKDHAVYIDFELMSGTPFQAAKRLQFNLDMEPVEGIEPMKNLPKLILPMFWVEEGVQLNKTYTNLVKYTLFLGLKINSVLRWSLITFSLVGLMFSAYLFYHKSDSLDINSILKDNNKVDDVASTKEPLPSANPKQSSTVHPVQLPNTLIPGTNPATNPATHHKMEHRERY
Protein: Transcription factor TGA7 (bZIP transcription factor 50) (AtbZIP50) (Q93ZE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1 (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Regulatory protein NPR1
- Regulatory protein NPR4
- Regulatory protein NPR3
- Regulatory protein NPR5
- Regulatory protein NPR6
- Regulatory protein NPR2
- Basic leucine zipper 8
- At4g33925
Sequence:
MMSSSSPTQLASLRDMGIYEPFQQIVGWGNVFKSDINDHSPNTATSSIIQVDPRIDDHNNNIKINYDSSHNQIEAEQPSSNDNQDDDGRIHDKMKRRLAQNREAARKSRLRKKAYVQQLEESRLKLSQLEQELEKVKQQGHLGPSGSINTGIASFEMEYSHWLQEQSRRVSELRTALQSHISDIELKMLVESCLNHYANLFQMKSDAAKADVFYLISGMWRTSTERFFQWIGGFRPSELLNVVMPYLQPLTDQQILEVRNLQQSSQQAEDALSQGIDKLQQSLAESIVIDAVIESTHYPTHMAAAIENLQALEGFVNQADHLRQQTLQQMAKILTTRQSARGLLALGEYLHRLRALSSLWAARPQEPT
Protein: Prestin (Solute carrier family 26 member 5) (Q7T2C4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000269|PubMed:17272340, ECO:0000269|PubMed:17442754}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Vesicular glutamate transporter 3
- Transmembrane channel-like protein 1
Sequence:
MEHVTVSEEPSATLMYHVERPIFSEAYIDSELLHKRKKTPKPYKLRVAEHLCCSSEKVKSVVFGFLPILTWLPSYPLKEYLFGDIVSGISTGVMQLPQGLAYAMLAAVPPVFGLYSSFYPVLLYTFFGTSKHISIGTFAVISLMIGGVAVREAPDSMFMVNGTNSSLVVNIEARDSRRVEVVVALTTLVGIIQFVLGLLRFGFLAIYLTEPLVRGFTTAAAVHVSVSQLKYLLGVKTARFNGPLSVVYSLDAVLRNIADTNIVTLIIGLGCTVFLYIIKQLNERFKKKLLIPIPGEIIVVIVSTGISYGMLMSENYGVDVVGKIPTGLLPPKVPDFSVFPNLFADAVPIAVVGFSITISLAKTFALKYGYSVDGNQELIALGLCNFVSSFFHTFVVTASMSRSLVQESTGGHTEIAGLLASLLVLLVVVAIGFVFQPLPTTVLAAIIMVNLLGMFKQTRDIPVLWRKSKIELAIWLVSFFASVLLGLDYGLAVAMAFAILTVIYRTQRPKNVVLGQIPDTGLYFDVDEYEEAEECSGIKIFQSNSSIYFANSELYVKALKAKTGIDPEKLLDAKKLQLKYAKRDTEGTKTVNQGSLLKKNAVVLLDMELGVTHEVLNGPQKPKHVHTNGQMTEKHIESESEDEFFLQRLTPIHSVILDFTPVNFIDSVGAKTIKSVIKEYATVDVKVVLAGCSRTLLSELRTLQFFSEPVTPDLIFPTIHDAVLQCKRWRDLPVHPNIH
Protein: Phosphatidylcholine synthase (PC synthase) (PCS) (EC 2.7.8.24) (CDP-diglyceride-choline O-phosphatidyltransferase) (Q1MGQ9)
Organism: Rhizobium johnstonii (strain DSM 114642 / LMG 32736 / 3841) (Rhizobium leguminosarum bv. viciae)
Function: Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:Q9KJY8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9KJY8}.
Interaction partners:
Sequence:
MKIFNYKRVPYAEMRAFSVHILTASGSFLAFLGVVAAAEHRFIDMFWWLGLALLVDGIDGPIARKVRVKEVLPNWSGDTLDNIIDYVTYVLLPAFALYQSGMIGEPWSFVAAGMIVVSSAIYYADMGMKTDEYFFSGFPVVWNMIVFTLFVIDASATTALTVVIVSVVLTFLPINFLHPVRVKRLRPLNLGVFFLWSALGIFSLLMHFDTPEWALILFIVTGAYLYVIGAVLQFFPALGRET
Protein: Rac-like GTP-binding protein ARAC5 (AtRAC5) (GTPase protein ROP4) (Q38937)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cell polarity control during the actin-dependent tip growth of root hairs, thus regulating root hair length and root hair initiation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10798620}. Membrane {ECO:0000269|PubMed:10798620}; Peripheral membrane protein {ECO:0000269|PubMed:10798620}. Cell membrane {ECO:0000250|UniProtKB:Q38919}; Peripheral membrane protein {ECO:0000255}. Note=Associated with the membrane when activated. The localization to the plasma membrane requires YIP4A and YIP4B (By similarity). {ECO:0000250|UniProtKB:Q38919}.
Interaction partners:
- Rho guanine nucleotide exchange factor 8
- Guanine nucleotide exchange factor SPIKE 1
- Rho GDP-dissociation inhibitor 1
- CRIB domain-containing protein RIC4
- CRIB domain-containing protein RIC1
- Rho GTPase-activating protein 6
- Receptor-like cytosolic serine/threonine-protein kinase RBK1
- KOW domain-containing protein
- Receptor-like cytosolic serine/threonine-protein kinase RBK2
- Kinesin-like protein KIN-14E
Sequence:
MSASRFIKCVTVGDGAVGKTCMLISYTSNTFPTDYVPTVFDNFSANVVVDGNTVNLGLWDTAGQEDYNRLRPLSYRGADVFILAFSLISKASYENVAKKWIPELRHYAPGVPIILVGTKLDLRDDKQFFIDHPGAVPITTNQGEELKKLIGSPIYIECSSKTQQNVKAVFDAAIKVVLQPPKQKKKKKNKNRCVFL
Protein: 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Enamine/imine deaminase) (Q8U308)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Elongation factor 2
- Diphthine synthase
- N-type ATP pyrophosphatase superfamily
- Exosome complex component Rrp41
Sequence:
MKEVIFAENAPKPIGPYSQAIKAGNFLFIAGQIPIDPKTGEIVKGDIKAQTRQVLENIKAILEAAGYSLTDVVKVTVYLKDMNDFAKMNEVYAEYFGESKPARAAVEVSRLPKDVLIEIEAIAYKE
Protein: Uncharacterized protein (Q386D6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
METKESCREQDPDVVCGQEEAQTPEATCGEEATETQEAPEATEMKGEEQQDDNPSCENEEAQNAGAPPDEEEGDVTEPPDAAAGSHTSQEAGVNSVTAEGGSACTSPKGVSVTAPSPTEDNFPDRQPQIRRRLSCAGLRIGEHSRQVDEEYGYPPSHYHTLTVNCGGANGDGDNINCGQPFAPMARGVGLVDLPSMYAKKDNANGDAVLPAASLFAHGSPGEEWESTFTVKMGLHANDDD
Protein: Ubiquitin carboxyl-terminal hydrolase-related protein (F4JCR3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGQKKKTSASRSKQPPSSTAVTVVEVEPSEISACSFNDGGFSGPDANGEPLDSSVVKLECEKALKSFGRGSYNKAIRLIKDSCSRHQDSALIHRVQGTICVKVAAVYEDLATKQKYLRNAIESARKAVELSPNSIEFGHFYANLLYEAANEGKREYEEVVQECHRALSIEYPIDPARESLQDETQLKILTPEARIAHFQDELRSLIQKSNIYSLSTWMQTLGNGEEKFRLIPLRRMAEDPIESNLIQSRRPNEIKKSTKTNEERRKEIEVRVAAHRLLQQKSESSPSENVEAVNNKGSDSALAAGPRSGERRKHGNARKNGSTADRRDRVRSYWDSLSKEMKKEFLRVKFSDLKSHFSGSKDGQAYEIVSEALSFCEANKTWRFWACCRCSQNFIESEAHMHHIVQAHMGNVLPKMQMVLPQIVDTERIDMLFKSPWKPLDLSATLKLLRSQQKIQNSEFDEFHSGDNMDGGDDCFKDAWNDTTPDGDTCNGWNENESEEEVKLSIAFPPPDGWPISDDPERAKLLEKIRAAFEQLIRHKYLAASHHDKVIQFTLDELQNLPSVSQFLNRGLNKSPLCICFLGASHLSKILKFLQDLSQACGLSRYSEQSNPHDEINFGDLGREVTEEILLDSEDSCLLMDEKLLGTECIQEKYMGSAFNNVTIASSGDIANGNDVSSGADGFLSWIFTGPSSEEQVVSWMRTKEDKTNQGLEIMQHLEKEFYHLQNLCERKCEHLSYEGALQTVEDLCLEEGRKRETSAEFTHESYETVLRKRREELNESDHELLFISSRFELDAITNVLKDAETLNHNQFGYEESYGCTSSQLRDLESGEADEWGIKDSLHEADSFIEIAIQKQKEQLSAELSRIDAQMMRNVTGMQQLELKLGPVSSNDYQIVLLPLVKSYMRAHLEALAEKDATEKSDAAREALLVELALDSKKEARGRNDNSKNTLEKSKDKKKIKDTRKVKDMKATIGSDHRSNADSVEHSPLPVAPVGDHSEADIVSEAVEALKEEEEEYKRQIELEEEERKLEKTLEYQRRIEDEAKEKHMAEQQKKYSSSVPMNVAKTVYNGCTDNEVDYLVLQGQEKSINQEKRNGRLDDLEGASVNTNGVFPSTNHSAISDTAKVQNVKSQKVVPNGTAMQAGIFQSDQRTGRRTRRQKASNKLADGKYPVTPPETENSKSQLSGTNGERHSETLRNNGDVGTKTLRQLQAEDDDEERFQADMQRAVLQSLDVYQGGRNMASCLRTPLEVNNDGGLSDDTMESRSSTGVTIFGTGLQNEVGEYNCFLNVIIQSLWNLELFRAEFLRSSTREHHHVGDPCVVCSLYEIFTALSAASSEKQNEPVAPSSLRIALSNLYPDSSFFQEAQMNDASEVLAVIFDCLHRSFAQSSSVSDVDSSDSNCTGSWDCANRTCIAHSLFGMDIFEQLNCYSCGLESRHLKYTSFFHNINASALRTMKVTCAENSFDELLNLVEMNHQLACDPETGGCGKLNHIHHILTTPPHVFTTVLGWQNTCETVEDIAATLAALNTEIDISIMYRGLDPKSTYSLVSVVCYYGQHYHCFAHSREHDQWIMYDDKTVKVIGSWIDVLSMCERGHLQPQVLLYERR
Protein: Transcription factor Tcf4 variant M5-9b (Q71G54)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPQLNGGGGDDLGANDEMISFKDEGEQEEKISENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKTRESLEEAAKRQDGGLFKSPPYPGYPFIMIPDLTSPYLPNGSLSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLQGDVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSSLLSSRFPPHMVPPHHSLHTTGIPHPAIVTPNVKQESSHSDIGSLNSSKHQDAKKEEEKKKQPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKQAGEGNEHREYFPNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCSPNLLSFCSNTSSL
Protein: X-ray radiation resistance-associated protein 1 (Q6P2D8)
Organism: Homo sapiens (Human)
Function: May be involved in the response of cells to X-ray radiation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12908878}. Nucleus {ECO:0000269|PubMed:12908878}.
Interaction partners:
- X-ray repair cross-complementing protein 5
Sequence:
MAFSGIYKLDDGKPYLNNCFPARNLLRVPEEGQGHWLVVQKGNLKKKPKGLVGAQAERRESLKATSFEFKGKKESRRENQVDLPGHILDQAFLLKHHCVRKPSDLCTINAKENDFKHFHSVIYINASENLLPLEAFHTFPALKELDLAFNGIKTIYVKYGDFKLLEFLDLSFNSLTVEAICDLGILPHLRVLLLTGNGLTSLPPNLAVAEQEASVTSLTSKRYILRFPALETLMLDDNRLSNPSCFASLAGLRRLKKLSLDENRIIRIPYLQQVQLYDESVDWNGGRGSPHKEPQFMLQSKPRMLEDSDEQLDYTVLPMKKDVDRTEVVFSSYPGFSTSETTKICSLPPIFEILPVKSLKARNQTLAPPFPELRYLSLAYNKIAKEDAVLPVALFPSLCEFVFHNNPLVAHTRGVPPLLKSFLQERLGIHLIRRKIVKPKHHVLMSRKESWKVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPKGIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLVNHKQYLEAKRLLKEFQARYRQLVSGSLRTVFGTTPLPMACPALSESQPKFGHFLEFMDEFCQEPTASDSQG
Protein: Tripartite motif-containing protein 42 (Q8IWZ5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
METAMCVCCPCCTWQRCCPQLCSCLCCKFIFTSERNCTCFPCPYKDERNCQFCHCTCSESPNCHWCCCSWANDPNCKCCCTASSNLNCYYYESRCCRNTIITFHKGRLRSIHTSSKTALRTGSSDTQVDEVKSIPANSHLVNHLNCPMCSRLRLHSFMLPCNHSLCEKCLRQLQKHAEVTENFFILICPVCDRSHCMPYSNKMQLPENYLHGRLTKRYMQEHGYLKWRFDRSSGPILCQVCRNKRIAYKRCITCRLNLCNDCLKAFHSDVAMQDHVFVDTSAEEQDEKICIHHPSSRIIEYCRNDNKLLCTFCKFSFHNGHDTISLIDACSERAASLFSAIAKFKAVRYEIDNDLMEFNILKNSFKADKEAKRKEIRNGFLKLRSILQEKEKIIMEQIENLEVSRQKEIEKYVYVTTMKVNEMDGLIAYSKEALKETGQVAFLQSAKILVDQIEDGIQTTYRPDPQLRLHSINYVPLDFVELSSAIHELFPTGPKKVRSSGDSLPSPYPVHSETMIARKVTFSTHSLGNQHIYQRSSSMLSFSNTDKKAKVGLEACGRAQSATPAKPTDGLYTYWSAGADSQSVQNSSSFHNWYSFNDGSVKTPGPIVIYQTLVYPRAAKVYWTCPAEDVDSFEMEFYEVITSPPNNVQMELCGQIRDIMQQNLELHNLTPNTEYVFKVRAINDNGPGQWSDICKVVTPDGHGKNRAKWGLLKNIQSALQKHF
Protein: BTG family protein (Q54NU5)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- poly
- poly
- Transcription factor E2F/dimerisation partner family protein
- Retinoblastoma-like protein A
- Myb domain-containing protein
Sequence:
MSPYAPENNQDPGGGLVTEGNQPQQNNFVNTNKSPTTTPPPQTSNVVSTPPATAINAAGVNNGLINGVLNNSSSSSSSSSSSSSSSPTPTSISPPLSDIEQTLNAYPTDLPELVVAACWWAESLGKLNMNIPKENIKRFRKELIFALRDRIKGHWYPDYPERGQGYRAIICEETTDRLLMDAAKKSDIVGEFRQLVKQNTTMWIDPGNVTYRHGKHYEKTLYPFNSINNHYSHHNNNNNNNNGINITNSNNTIPINTSGYHNINNHLNNSNNTIPPQQSQQHINNNNNNSNNNTTNNIILNSLHHHQTQISQQHLNNNNNQNNFSYGITSTRLTQNVVNSNSNGLNGRVSSPSLSSTAPVFSPSNSMYHHVQQQSHSPSISPPASPSKDLGNSSGNNTNVYSSNNNLFYNSNTSSSKIKLAYS
Protein: Peroxisomal targeting signal import receptor (Q13335)
Organism: Homo sapiens (Human)
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
Sequence:
YDEYHPEEDLQHTASDFVAKVDDPKLANSEFLKFVRQIGEGQVSLESGAGSGRAQAEQWAAEFIQQQGTSDAWVDQFTRPVNTSALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSATG
Protein: Glycerophosphocholine phosphodiesterase gde1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase gde1) (Q9C104)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Lysophospholipase NTE1
- Choline kinase
- Acyl-protein thioesterase 1
- Vacuolar transporter chaperone complex subunit 2
- Probable lysophospholipase 3
- Probable lysophospholipase 5
- Probable lysophospholipase 4
- Lysophospholipase 1
- Probable lysophospholipase 2
- Cyclin-dependent kinase 1
Sequence:
MKFGESLQLALIPEFAEQYVDYNGIKRKIQLVAALPEDERKKLLRRNSDGSWPKGSIDEMLENDLQKVVNLFNTRIVQLDNYVTRLSTEKSPNTEITQALSSSYEAEEKAKQLKELDFRLQQLSSFCEWNKLAFEKLAANMDKHLGTERLVTFYEQKVCKLDFANSSKIYESMIALKALNSSQNDSEVKDKLEKLSIHHPLKKDLLAFIQLDIAAEVVTACINAPDSVLVDILAASIIAGAKACMREVIGRIGLRSECLASALRRAINNLCGPDEGVLYFLEVLKQICSVVYVDSYHSNRLLSRILLVERNSKGQSVMHSVAKLGWAGLCSKFCEIVSSIPDSEPLNWMLPCWRDVMHDTPLTLAIKGNHVEALHALLSAQDKETTSTKPGPVPPLVLTCCVGDYDLIVEELILAGFNPNEVDASSNTALHTAVRYNRPECVKMLLKLGANPSARDFLNSWTPLMLASATGLSEIVSILVASGASVDEVDSSGWTAMEQAVVRGYLHLADKLRTQVALSDKPVNLHTLYIKASSSEMRSRKRAMDLQLSRSVVIIRISDLAGRIRVSLQGDDAVYVSGRSPSFAASRPSSVDFMSQSTDSLSKNDTTASNGSMTPSSSQNNSVIIDIPRSHFDNAGEVCLENLAEPDEIADDSIHLHYDAAQENSPQPVNGSSPPYELVFVTRNTEEATITIDLLANRSHKILGRTVCCLTSLVSDLGNHMQSLKPLAPLPLLSSKTLKPIAHVNADVLISKVTVDDRFSSNDGISTPALSLEAVSNVSRTALEDAERSLHKSATTTSESGKSNGVAVIGHRGLGKNQPDRLSLQLGENTLQSFIKAADLGASYVELDVQMTKDMVPVVYHDFIVNETGTDAQVHSLTLEQFLGASHSPSEEIKDDASDIQQKRRPRAYSSSFTPSGSQVNFGEFAEENARLKPKVYKGNALGHTICAPFTTLKDVLKEVPQSVGLNVEFKYPMLSEAEEEKLLPIAYDYNFYVDTILSIIKKYGGKRKYIFSSFNPDICILLSLKSTNPVLFLTEGGTAYRTDVRAASLRQALKFASQWSFLGIVSACEPLIMCPRLIKAVKQLGLSCYTYGVLNNDVDNVRRQVRFGVDAVIVDNVLAIRRALNQYDESLESD
Protein: Wilms tumor protein homolog (P49952)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Subcellular location: [Isoform 1]: Nucleus speckle {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
Interaction partners:
- Nephrin
- Podocin
- Pre-mRNA-splicing regulator WTAP
- Transcription factor GATA-4
- Transcription factor 21
- Synaptopodin
- Cellular tumor antigen p53
- Podocalyxin
- Paired box 2
- SIX homeobox 2.
Sequence:
MGSDVRDLNALLPAVSSLGGGGGCGLPVSGARQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTLHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPSIRNQGYSTVTFDGAPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGMAAGSSSSVKWTEGQSNHGTGYESENHTTPILCGAQYRIHTHGVFRGIQDVRRVSGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWHSCQKKFARSDELVRHHNMHQRNMTKLHVAL
Protein: E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2) (Q9HAT8)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Interaction partners:
- Interleukin-1 receptor-associated kinase 1
- Interleukin-1 receptor-associated kinase 4
- TNF receptor-associated factor 6
- Ubiquitin-conjugating enzyme E2 N
Sequence:
MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPID
Protein: Mating factor alpha-1 (Alpha-1 mating pheromone) [Cleaved into: Mating factor alpha] (P01149)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The active factor is excreted into the culture medium by haploid cells of the alpha mating type and acts on cells of the opposite mating type (type A). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type a cells and synchronizing them with type alpha.
Interaction partners:
- Pheromone alpha factor receptor
- Mating factor alpha-2
- Pheromone a factor receptor
- Barrierpepsin
- Silenced mating-type protein ALPHA1
- Guanine nucleotide-binding protein subunit beta
- Guanine nucleotide-binding protein subunit gamma
- A-factor barrier protein 1
- Kexin
- Protein transport protein SEC61
Sequence:
MRFPSIFTAVLFAASSALAAPVNTTTEDETAQIPAEAVIGYLDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLDKREAEAWHWLQLKPGQPMYKREAEAEAWHWLQLKPGQPMYKREADAEAWHWLQLKPGQPMYKREADAEAWHWLQLKPGQPMY
Protein: Protein PHTF2 (Q8N3S3)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASKVTDAIVWYQKKEFLSVATTAPGPQQVLPGYCQCSLKDQGLFIQCLIGAYDQQIWEKSVEQREIKFIKLGLRNKPKKTAHVKPDLIDVDLVRGSAFAKAKPESPWTSLTRKGIVRVVFFPFFFRWWLQVTSKVIFFWLLVLYLLQVAAIVLFCSTSSPHSIPLTEVIGPIWLMLLLGTVHCQIVSTRTPKPPLSTGGKRRRKLRKAAHLEVHREGDGSSTTDNTQEGAVQNHGTSTSHSVGTVFRDLWHAAFFLSGSKKAKNSIDKSTETDNGYVSLDGKKTVKSGEDGIQNHEPQCETIRPEETAWNTGTLRNGPSKDTQRTITNVSDEVSSEEGPETGYSLRRHVDRTSEGVLRNRKSHHYKKHYPNEDAPKSGTSCSSRCSSSRQDSESARPESETEDVLWEDLLHCAECHSSCTSETDVENHQINPCVKKEYRDDPFHQSHLPWLHSSHPGLEKISAIVWEGNDCKKADMSVLEISGMIMNRVNSHIPGIGYQIFGNAVSLILGLTPFVFRLSQATDLEQLTAHSASELYVIAFGSNEDVIVLSMVIISFVVRVSLVWIFFFLLCVAERTYKQRLLFAKLFGHLTSARRARKSEVPHFRLKKVQNIKMWLSLRSYLKRRGPQRSVDVIVSSAFLLTISVVFICCAQLLHVHEIFLDCHYNWELVIWCISLTLFLLRFVTLGSETSKKYSNTSILLTEQINLYLKMEKKPNKKEELTLVNNVLKLATKLLKELDSPFRLYGLTMNPLLYNITQVVILSAVSGVISDLLGFNLKLWKIKS
Protein: F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) (O60907)
Organism: Homo sapiens (Human)
Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
Subcellular location: Nucleus {ECO:0000250}. Note=Colocalized with MECP2 to the heterochromatin foci. {ECO:0000250|UniProtKB:Q9QXE7}.
Interaction partners:
- Nuclear receptor corepressor 1
- G protein pathway suppressor 2
- F-box-like/WD repeat-containing protein TBL1XR1
- Histone deacetylase 3
- Catenin beta-1
- Nuclear receptor corepressor 2
- S-phase kinase-associated protein 1
- F-box-like/WD repeat-containing protein TBL1Y
- Thyroid peroxidase
- Adenomatous polyposis coli protein
Sequence:
MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Protein: Probable CCR4-associated factor 1 homolog 6 (EC 3.1.13.4) (Q9SAI2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Transcription regulator
- Transcription regulator NOT2/NOT3/NOT5 family protein
- Carbon catabolite repressor protein 4 homolog 1
- Probable NOT transcription complex subunit VIP2
- NOT2 / NOT3 / NOT5 family
- Cell differentiation, Rcd1-like protein
- Cell differentiation, Rcd1-like protein
- Cell differentiation, Rcd1-like protein
- CCR4-NOT transcription complex subunit 11
- AT5g35440/MOK9_2
Sequence:
MSLFLKDDSIQIREVWNDNLQEEMDLIRDVVDDFPYVAMDTEFPGIVVRPVGTFKSNADYHYETLKTNVNILKMIQLGLTFSNEQGNLPTCGTDKYCIWQFNFREFDLDSDIFALDSIELLKQSGIDLAKNTLDGIDSKRFAELLMSSGIVLNENVHWVTFHSGYDFGYLLKLLTCQNLPDSQTDFFKLINVYFPTVYDIKHLMKFCNSLHGGLNKLAELLEVERVGICHQAGSDSLLTSCTFRKLKENFFVGPLHKYSGVLYGLGVENGQVAI
Protein: Uncharacterized protein (Q383J8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVSPDRCMNKGSSPTFTDFPPLLLLLLSTSPSPNLLQIVTLAHTRMNVAWGTKTTRNCNEHMLMASPVADGSWNRSVRSLRCYSTESHRYNHTPCDGSIPIAFAPVGLSCLQTGAIVGHANQNSSIPVACQRGLCTYGHDVQLLQHHHQLYNQRQRLRRGAPREAPVAKETGSVEYGAGPPTGSNSKRPLRWEGSQSSLNESRKQKKRNSGSVRDLLFVAHVSNFSQLEELRRTNSLPDFLQSFVPKQANPPTTSMPMRFLIVVEKLYLAACVSIPPSPEDVVLSERTAVEFLEVRYVHCDDGHLLVDLKSGTCVAKRIHSTFRKALVQLSKLEAKLLTGEYAGTMQVLQDKSLFRGISYNPLVYAALFNLLTQNGGEEDIDAADLWSKLIREPTPNSSHSDTAERSHTRYEKAEDGEKHLVGDTASLLPSCGVALFSTVYGVRLFKRVMGIPGLRRLFFQLLVEAAQPMSVTEVTTPPPLKDDEALERSTANVTKRPSEQCFMAIFSCSLTSYFLFECFGLVDGADCCEEEVDIICACLKRSAVKVACSNGGSFTMIGLIKALSTRRFGECQRNWQGDEGSVIVHEKSASIIDPNSESNVLSTSSPHERLRERRVESDEKFFRAVIRGFVAGEGPGSTREEKVSRGRRVKFLTQHVIACRVTQSLIPVLVDSIHLMEDRMKKRQRQEPVRRGEEEEEDLLEVQYFEDCTAFLEEATDQCGLMVNHAHGNYVLQALIRELVKRSTPRSFVEKMLQKVSDMLIASILEVSKEKFASNCLEAMIDACKTARGGNGMILCLGSTLLRKGRDRMLQVTFDQYGNYVVRKMLNHITALAVGEQKAMESEREEARRLRGQYFSILAQNSEQLRTARYGSGIYDWICCQSSGIPASHK