wanglab/gogpt-training-data huggingface dataset:
Protein: Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) (Q8R1B4)
Organism: Mus musculus (Mouse)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
Interaction partners:
- Eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit E
Sequence:
MSRFFTTGSDSESESSLSGEELVTKPVSGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITNYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGVGNTTFLKKKQESSGESRKFHKKMEDDDEDSEDSEDEEWDTSSTSSDSDSEEEEGKQTVLASKFLKKAPTTEEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQVRGKKGTDRATQIELLQLLVQIAAENNLGVGVIVKIKFNIIASLYDYNPNLATYMKPEMWQMCLDCINELMDTLVAHSNIFVGENILEESENLHNFDQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEICQIYLRRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY
Protein: Delta-amaurobitoxin-Pl1b (Delta-AMATX-Pl1b) (Delta-palutoxin IT2) (Delta-paluIT2) (P83257)
Organism: Pireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus)
Function: Insecticidal toxin. Lethal to lepidopteran larvae. No adverse affects when intracerebroventricularly injected in mice at a dose of 0.2 ug but causes reversible paralysis of legs when injected intracerebroventricularly in mice at a dose of 2.0 ug. Binds to site 4 of insect voltage-gated sodium channel (Nav) and inhibits channel inactivation.
Subcellular location: Secreted {ECO:0000269|PubMed:10971590}.
Interaction partners:
Sequence:
ACVGDGQRCASWSGPYCCDGYYCSCRSMPYCRCRNNS
Protein: Sphingomyelin phosphodiesterase (EC 3.1.4.12) (EC 3.1.4.3) (Acid sphingomyelinase) (aSMase) [Cleaved into: Sphingomyelin phosphodiesterase, processed form] (P17405)
Organism: Homo sapiens (Human)
Function: Converts sphingomyelin to ceramide. Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly. However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form.
Subcellular location: Lysosome {ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18815062, ECO:0000269|PubMed:20530211, ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:27659707, ECO:0000269|PubMed:9660788}. Lipid droplet {ECO:0000269|PubMed:25339683}. Secreted {ECO:0000269|PubMed:12563314, ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:20530211, ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:22573858, ECO:0000269|PubMed:27659707, ECO:0000269|PubMed:8702487, ECO:0000269|PubMed:9030779, ECO:0000269|PubMed:9660788}. Note=The secreted form is induced in a time- and dose-dependent by IL1B and TNF as well as stress and viral infection. This increase of the secreted form seems to be due to exocytosis of the lysosomal form and is Ca(2+)-dependent (PubMed:20530211, PubMed:20807762, PubMed:22573858). Secretion is dependent of phosphorylation at Ser-510 (PubMed:17303575). Secretion is induced by inflammatory mediators such as IL1B, IFNG or TNF as well as infection with bacteria and viruses (PubMed:12563314, PubMed:20807762). {ECO:0000269|PubMed:12563314, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:20530211, ECO:0000269|PubMed:20807762, ECO:0000269|PubMed:22573858}.; SUBCELLULAR LOCATION: [Sphingomyelin phosphodiesterase, processed form]: Secreted, extracellular space {ECO:0000250|UniProtKB:Q04519}. Note=This form is generated following cleavage by CASP7. {ECO:0000250|UniProtKB:Q04519}.
Interaction partners:
- Sphingomyelin phosphodiesterase 2
- Sphingomyelin phosphodiesterase 3
- Lysosomal acid glucosylceramidase
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Phosphatidylcholine:ceramide cholinephosphotransferase 2
- Galactocerebrosidase
- Ceramide glucosyltransferase
- Sphingomyelin phosphodiesterase 4
- Acid ceramidase
- Ceramide synthase 6
Sequence:
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC
Protein: 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) (Q86JA1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P35998}. Nucleus {ECO:0000250|UniProtKB:P35998}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 1
- 26S proteasome non-ATPase regulatory subunit 3
- Proteasome subunit alpha type-2
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 6
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome non-ATPase regulatory subunit 4
- Proteasome subunit alpha type-5
- 26S proteasome non-ATPase regulatory subunit 2
Sequence:
MVNKEDVEDELLNETAPVALDEGDIALLKSYGVGPYSKSIRILEEDIKKMTSKVNELCGIKESDTGIGPPSQWDLVVDKTSAHEEPPLQVARCTKIIDVGKPNAKYIITVKQIAKFVVALGDKLSPTDVEEGIRVGVDRNKYQIQIPLPPKIDASVTMMQVEEKPDITYKDVGGCKEQIEKLREVVEMPLLHPEKFVNLGIDPPKGVLMYGPPGTGKTLCARAVANRTDAAFVRVIGSELVQKYVGEGARMVRDLFQMARSKKACIIFFDEVDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALLRPGRLDRKVEFGLPDLEGRAHIFTIHAKTMSCARDIRFELLARLCPNSTGADIRSVCTEAGMFAIRARRKVVSEKDFLEAIDKVIKSYAKFSATSRYMHYN
Protein: Syntaxin 16 (Syntaxin-16 isoform X2) (A0A2R8Q071)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Interaction partners:
Sequence:
MATRRLTDAFLLMRNNAIQNRQILAEQLADDRMALVSGISLDPEAAIGVTKRLPPKWVEGVDEIQYEITRIRQKMKELASLHDKHMNRPTLDDSSEEEHAIEITTQEITQMFHRCQRAVTGLQTQSYHCTEQENRLLTNVVSSLAQSLQELSLNFRHTQSGYLKRMKNREERSKHFFDSGPLVEEDEDIALYDRGFTDDQLVLVQQNTVMVEEREREIRQIVQSISDLNEIFRDLAGMVVEQGTVLDRIDFNVEQSCVKTEEGLQQLQKAEQYQKKNRKMLVILILFVIVVVLILILFGTKFS
Protein: Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.4.19.12) (Deubiquitinating enzyme 44) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) (Q7ZUM8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Deubiquitinase that plays a key role in the spindle assembly checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription and mRNA export factor ENY2
- Cell division cycle 20 homolog
- SAGA-associated factor 29
- Ubiquitin-ribosomal protein eS31 fusion protein
- E2 ubiquitin-conjugating enzyme
- Transcription initiation factor TFIID subunit 10
- E3 ubiquitin protein ligase
- Transformation/transcription domain-associated protein
Sequence:
MDRCKHVGRLRLAQDHSILNPQKWHCVDCNTTESVWACLSCSHVACGRYIEEHALQHFKEQHHPLALEVNELYVYCYLCDDYVLNDNATGDLKLLRSTLSAIKSQCYEVTTRSGRTLRSSSANGDQLSPSTQELQLRDEDRMFTALWHRRRALIGRLFRLWFAQTERGKKRLEEERQQEEEEERKREARERRRQLKRQLKEELESAPPRKSHRIRRQSLKATSVKPARAPAKSTKSVRRRSAPARVSTPTPRTPRERTPQQRPRPQAKAKRPQAPPSKTGDSPVKRRPTVTPGVTGLRNLGNTCYMNSILQVLSHLHVFRECFLRLDLNQALELLASAVSRKLGLSAQRVIQPKGLNQGSGLSGGASRSRNMELIQPKEPSSKHISLCHELHTLFPVMWSGKWALVSPFAMLHSVWQLIPAFRGYAQQDAQEFLCELLDKVQHELERTRTLTPATVPANQRRLIKQVLSVVNTIFHGQLLSQVRCLACDHRSNTIEPFWDLSLEFPERYHSNSKDAAQVPCGLTEMLAKFTETEALEGAIYACDYCNNKRRRFCSKQVVLTEAQKQLMVHKLPHVLRLHLKRFRWSGRNHREKIGVHVQFEQELNMEPYCCKDSGNLPHPQHFLYQLSAVVMHHGKGFGSGHYTAFCYNTEGGFWVHCNDSKLSVCAVEEVCKAQAYILFYTQRNAQDKSKESDL
Protein: F-box protein At2g02240 (Q3E6P4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MCGQHYTSIISSITTEASFERVRTHEFIKFSKHKRFDQRHRSMMGQYHSGGEIVSPGTSPFDVLPEDCISNIISFTSPRDACVAASVSKTFESAVSSDCVWDKFLPPEYESLVSRSRVFASKKELYFALCHNPVLIEDGKKSFWLEKASGKRCIMLSSKELWITWGSSPEYWQWISIPESRFNKIAELLDVCWFEIRGKTSARVLSPGTRYSAYIVFKTKDRCPGLGHLPVEVGLGLVGQESSKRFIYFIGPRDRRGRRETRDVTKPDQREDGWMEAELGEFFNEERCDEIEFSVIEIKSPSWKSGLIIQGIEFRPTKSQ
Protein: CHD3-type chromatin-remodeling factor PICKLE (EC 3.6.4.-) (Protein CHROMATIN REMODELING 6) (AtCHR6) (Protein GYMNOS) (Q9S775)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Chromatin remodeling factor that represses the expression of embryonic trait genes (such as NFYB9/LEC1) upon and after seed germination and thus enables the developmental switch to post-germinative growth. Silences some MADS-box proteins such as PHE1 and PHE2. Plays a role during carpel differentiation. Regulates late processes in cytokinin signaling.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:16359393, ECO:0000269|PubMed:19245862}.
Interaction partners:
- High mobility group B protein 10
- High mobility group B protein 9
- High mobility group B protein 15
- Putative high mobility group B protein 11
- Histone deacetylase 19
- Histone-lysine N-methyltransferase EZA1
- Histone-lysine N-methyltransferase CLF
- Histone-binding protein MSI1
- Chromo domain-containing protein LHP1
- Histone deacetylase 6
Sequence:
MSSLVERLRIRSDRKPVYNLDDSDDDDFVPKKDRTFEQVEAIVRTDAKENACQACGESTNLVSCNTCTYAFHAKCLVPPLKDASVENWRCPECVSPLNEIDKILDCEMRPTKSSEQGSSDAEPKPIFVKQYLVKWKGLSYLHCSWVPEKEFQKAYKSNHRLKTRVNNFHRQMESFNNSEDDFVAIRPEWTTVDRILACREEDGELEYLVKYKELSYDECYWESESDISTFQNEIQRFKDVNSRTRRSKDVDHKRNPRDFQQFDHTPEFLKGLLHPYQLEGLNFLRFSWSKQTHVILADEMGLGKTIQSIALLASLFEENLIPHLVIAPLSTLRNWEREFATWAPQMNVVMYFGTAQARAVIREHEFYLSKDQKKIKKKKSGQISSESKQKRIKFDVLLTSYEMINLDSAVLKPIKWECMIVDEGHRLKNKDSKLFSSLTQYSSNHRILLTGTPLQNNLDELFMLMHFLDAGKFGSLEEFQEEFKDINQEEQISRLHKMLAPHLLRRVKKDVMKDMPPKKELILRVDLSSLQKEYYKAIFTRNYQVLTKKGGAQISLNNIMMELRKVCCHPYMLEGVEPVIHDANEAFKQLLESCGKLQLLDKMMVKLKEQGHRVLIYTQFQHMLDLLEDYCTHKKWQYERIDGKVGGAERQIRIDRFNAKNSNKFCFLLSTRAGGLGINLATADTVIIYDSDWNPHADLQAMARAHRLGQTNKVMIYRLINRGTIEERMMQLTKKKMVLEHLVVGKLKTQNINQEELDDIIRYGSKELFASEDDEAGKSGKIHYDDAAIDKLLDRDLVEAEEVSVDDEEENGFLKAFKVANFEYIDENEAAALEAQRVAAESKSSAGNSDRASYWEELLKDKFELHQAEELNALGKRKRSRKQLVSIEEDDLAGLEDVSSDGDESYEAESTDGEAAGQGVQTGRRPYRRKGRDNLEPTPLMEGEGRSFRVLGFNQSQRAIFVQTLMRYGAGNFDWKEFVPRLKQKTFEEINEYGILFLKHIAEEIDENSPTFSDGVPKEGLRIEDVLVRIALLILVQEKVKFVEDHPGKPVFPSRILERFPGLRSGKIWKEEHDKIMIRAVLKHGYGRWQAIVDDKELGIQELICKELNFPHISLSAAEQAGLQGQNGSGGSNPGAQTNQNPGSVITGNNNASADGAQVNSMFYYRDMQRRLVEFVKKRVLLLEKAMNYEYAEEYYGLGGSSSIPTEEPEAEPKIADTVGVSFIEVDDEMLDGLPKTDPITSEEIMGAAVDNNQARVEIAQHYNQMCKLLDENARESVQAYVNNQPPSTKVNESFRALKSINGNINTILSITSDQSKSHEDDTKPDLNNVEMKDTAEETKPLRGGVVDLNVVEGEENIAEASGSVDVKMEEAKEEEKPKNMVVD
Protein: Isocitrate dehydrogenase [NADP] 2 (ICD-2) (IDH 2) (EC 1.1.1.42) (Oxalosuccinate decarboxylase) (O53611)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- 2-oxoglutarate oxidoreductase subunit KorA
- Aconitate hydratase A
- 2-oxoglutarate oxidoreductase subunit KorB
- Isocitrate dehydrogenase 1
- Malate dehydrogenase
- Glutamate synthase large chain
- Adenylosuccinate lyase
- NAD-specific glutamate dehydrogenase
- Argininosuccinate lyase
- Glutamate synthase small chain
Sequence:
MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDISVAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQDKGYAVPDYPADPKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHSMGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALCDFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQFDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKLAVTRARISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQLAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYAPDSDMTTAVMRPSKTFNAALEAVQG
Protein: Multidrug resistance protein MdtK (Multidrug-efflux transporter) (P37340)
Organism: Escherichia coli (strain K12)
Function: Multidrug efflux pump that probably functions as a Na(+)/drug antiporter. Confers resistance to many drugs such as fluoroquinolones (norfloxacin, ciprofloxacin, enoxacin) and tetraphenylphosphonium ion (TPP). Also to deoxycholate, doxorubicin, trimethoprim, chloramphenicol, fosfomycin, ethidium bromide and benzalkonium. Also able to export peptides; when overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}.
Interaction partners:
- Multidrug transporter MdfA
- Macrolide export ATP-binding/permease protein MacB
- Outer membrane protein TolC
- DNA damage-inducible protein F
- Penicillin-insensitive murein endopeptidase
- Multidrug resistance protein D
- Multidrug export protein EmrB
- Multidrug resistance protein MdtH
- Probable aminoglycoside efflux pump
- Multidrug resistance protein MdtL
Sequence:
MQKYISEARLLLALAIPVILAQIAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRERIAHQVRQGFWLAGFVSVLIMLVLWNAGYIIRSMENIDPALADKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATAAVYWVMFLAMVSYIKRARSMRDIRNEKGTAKPDPAVMKRLIQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPMSLAAAVTIRVGYRLGQGSTLDAQTAARTGLMVGVCMATLTAIFTVSLREQIALLYNDNPEVVTLAAHLMLLAAVYQISDSIQVIGSGILRGYKDTRSIFYITFTAYWVLGLPSGYILALTDLVVEPMGPAGFWIGFIIGLTSAAIMMMLRMRFLQRLPSAIILQRASR
Protein: Proteasome subunit beta 1 (EC 3.4.25.1) (20S proteasome beta subunit 1) (Proteasome core protein PrcB 1) (Q53079)
Organism: Rhodococcus erythropolis (Arthrobacter picolinophilus)
Function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The R.erythropolis proteasomes are able to cleave oligopeptides after Tyr, Phe and Leu, very poorly after Arg but not after Glu. Thus, displays chymotrypsin-like activity, low trypsin-like activity but no caspase-like activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02113}.
Interaction partners:
Sequence:
MTADRPALRTGDRDTRLSFGSNLSSFTDYLRGHAPELLPENRIGHRSHSTRGGDGMESGDLAPHGTTIVALTYKGGVLLAGDRRATQGNLIASRDVEKVYVTDEYSAAGIAGTAGIAIELVRLFAVELEHYEKIEGVPLTFDGKANRLASMVRGNLGAAMQGLAVVPLLVGYDLDADDESRAGRIVSYDVVGGRYEERAGYHAVGSGSLFAKSALKKIYSPDSDEETALRAAIESLYDAADDDSATGGPDLTRGIYPTAVTITQAGAVHVSEETTSELARRIVAERTEQGGSAR
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) (Q69Z28)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
Sequence:
MESRGCAALWVLLLAQVSEQQTPACALGLAAAASGSPEDPQPPPFSGSSWLETGEYDLVSAYEVDHRGDYVSHDIMHYQRRRRRRAVTQPGGDALHLRLKGPRHDLHLDLKAASNLMAPGFMVQTLGKGGTKSVQMFPPEENCFYQGSLRSQGNSSVALSTCQGLLGMIRTKDTDYFLKPLPPHLTSKLNRSAQGDSPSHVLYKRSTERQAPRENEVLMITRKRDLARPHLHHDNFHLGPSQKQHFCGRRKKYMPQPPNDDLYILPDEYKPSSRHKRSLLKSHRNEELNVETLVVVDRKMMQSHGHENITTYVLTILNMVSALFKDGTIGGNINIVIVGLILLEDEQPGLAISHHADHTLTSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTVNEDSGLGLAFTIAHESGHNFGMVHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSSCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGQLYDANTQCKWQFGEKAKLCMLDFRKDICKALWCHRIGRKCETKFMPAAEGTLCGQDMWCRGGQCVKYGDEGPKPTHGHWSDWSPWSPCSRTCGGGISHRDRLCTNPRPSHGGKFCQGSTRTLKLCNSQRCPLDSVDFRAAQCAEYNSKRFRGWLYKWKPYTQLEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGMCERVGCDNVLGSDATEDSCGVCKGNNSDCVTHRGLYSKHHSTNQYYHMVTIPSGARSIHIYETNISTSYISVRNSLKRYYLNGHWSVDWPGRYKFSGATFNYKRSYKEPENLTSPGPTNETLIVELLFQGRNPGVAWEFSLPRSGAKKTPAAQPSYSWAIVRSECSVSCGGGKMNSKAGCYRDLKVPVNASFCNPKTRPVTGLVPCKVSPCPSSWSVGNWSVCSRTCGGGTQSRPVRCTRRAHYRDESIPASLCPQPEPPIHQACNSQSCPPAWSTGPWAECSRTCGKGWRKRTVACKSTNPSARAQLLHDTACTSEPKPRTHEICLLKRCHKHKKLQWLVSAWSQCSVTCQGGTQQRVLRCAEKYISGKYRELASKKCLHLPKPDLELERACGLIPCPKHPPFDASGSPRGSWFASPWSQCTASCGGGVQRRTVQCLLRGQPASDCFLHEKPETSSACNTHFCPIAEKRGTFCKDLFHWCYLVPQHGMCGHRFYSKQCCNTCSKSNL
Protein: Interferon regulatory factor 6 (Irf6 protein) (Q6PGZ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Grainyhead-like transcription factor 3.
- Rho GTPase-activating protein 29
- Forkhead box E1.
- Receptor-interacting serine-threonine kinase 4.
- T-box transcription factor 22
- Tumor protein 63
Sequence:
MSSHPRRVRLKPWLVSQVDNATFPGLVWLDRDAKRFQIPWKHATRHTPQQEEENTIFKAWAVETGKYQEGVDEPDPAKWKAQLRCALNKSREFNLIYDGTKEVPMNPLKIYDVCDIPQTPSNPGSVPTYETDGDEDDIPDTPEPPPPYASHGMSASPLAAVWTPPGSVSPLQPSSCAPPPALPPPPALPPPAATVLPAAAAPPANVWPKKEPEDVEMQPPPMEIQTPTALDNLFITPETWISSLPMTDLEVQFYYRGKEVCPPLTVSNPQGCRLFYGDLGPIVNQEELFGPVSLEQVRFPPTEHIANDKQRVFTSRLLDVMDRGLILEVSGHDIYAVRLCQCKVYWSGPCAPNPNAPNLIERQQKVKLFCLESFLSGVITHQRGQSSDAPLYDIHLCFGEEWPDGRPRERKLIMVQVVPVVARMISEMFSGDCTRSFDSGSVRLQISIPDIKDNIVTHLKQLYRLLQTHQGPENWPLPPGAALQLSSALHTQ
Protein: Glutamate metabotropic receptor 5 (H0ZRP5)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha
- Uncharacterized protein.
- Metabotropic glutamate receptor 1
Sequence:
MVLLLFLAILLLKEDVCGNFGLLVSAQANERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGEVREQYGIQRVEAMLHTLDRINLDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGMVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQAKAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMAAKEGICIAHSYKIYSNAGEQSFDKLLRKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTEGYQNEAVGGITIKLQSPDVKWFDDYYLQLRPETNHRNPWFQEFWQHRFQCRLEGFPQENPKYNKTCTSQMTLRTQHVQDSKMGFVINAIYSMAYGLHNMQLSLCPGYVGLCDAMKPIDGRKLLESLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKQMGKDYFDYINVGSWDNGELKMDDDEIWSEKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVSDEYTCKACQLGSWPNEDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTIVFIMYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPQQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKGRRLAPPNKSEIECFTPKGSMGNGGRATMTSEESVCIPDCNRSESSREEKKVPVKEDALTVKKTGNCVSLIVPQQDCQLQDLLKHSNGKSVSWAQNEKSSRGAHLWQRLSVHINKKENPNQTAVIKPFPKSTDSSRHSSSATFPEASAKTLYDVSEAEEQYPAQYRPQTPSPISTLSHRTASVSRTEDEAPTFQSEPPQRSSSSQGSLMEQISSVVTRFTANISELNSMMLSTSTPGTMGAAPLCSSYLIPREIQLPTTMTTLAEIQPLPAIEVNGASQSARKPSNDSIKEGTSETPTAKQDLEELVALTPPSPFRDSIDSGSASPSSPASESALCIPSSPKYDTLLIRDYTQSSSSL
Protein: Protein FAM199X (Q6PEV8)
Organism: Homo sapiens (Human)
Interaction partners:
- 3-phosphoinositide-dependent protein kinase 1
- WD repeat-containing protein 5
Sequence:
MSDEASAITSYEKFLTPEEPFPLLGPPRGVGTCPSEEPGCLDISDFGCQLSSCHRTDPLHRFHTNRWNLTSCGTSVASSEGSEELFSSVSVGDQDDCYSLLDDQDFTSFDLFPEGSVCSDVSSSISTYWDWSDSEFEWQLPGSDIASGSDVLSDVIPSIPSSPCLLPKKKNKHRNLDELPWSAMTNDEQVEYIEYLSRKVSTEMGLREQLDIIKIIDPSAQISPTDSEFIIELNCLTDEKLKQVRNYIKEHSPRQRPAREAWKRSNFSCASTSGVSGASASASSSSASMVSSASSSGSSVGNSASNSSANMSRAHSDSNLSASAAERIRDSKKRSKQRKLQQKAFRKRQLKEQRQARKERLSGLFLNEEVLSLKVTEEDHEADVDVLM
Protein: b(0,+)-type amino acid transporter 1 (b(0,+)AT) (4F2-LC6) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9) (Q9N1R6)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:P82251}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P82251}.
Interaction partners:
- Amino acid transporter heavy chain SLC3A1
- Amino acid transporter heavy chain SLC3A2
- b
- Amino acid transporter
- Amino acid transporter
- Amino acid transporter
- Amino acid transporter
- Amino acid transporter
- Amino acid transporter
- Transporter
Sequence:
MGETVPRRRREDEKSIQSDEPKTTSLQKEVGLISGICIIVGTIIGSGIFISPKSVLSNTQAVGPCLIIWAACGVLGTLGALCFAELGTMITKSGGEYPYLMEAFGPIPAYLFSWSSLLVMKPSSFAIICLSFSEYVATPFYSGCEPPKVVVKCLAAAAIMLITTVNSLSVRLGSYVQNFFTAAKLVIVAIIIISGLVLLAQGNTKNFENSFEGAEVSVGAISLALYNGLWAYDGWNQLNYITEELRNPFRNLPLAIIFGIPLVTVCYILINISYFTVMTPTELLQSQAVAVTFGDRVLYPASWIVPVFVAFSTIGAANGTCFTAGRLVYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIVATIYIIPGDINSLVNYFSFATWLFYGLTILGLIVMRFTRKELERPIKVPIFIPILVTFIAAFLVLAPVITNPAWEYLYCVLFILSGLVFYFLFVYYKFEWAQKISKPITMHLQMLMEVVPPEPDPK
Protein: Protein kinase C (EC 2.7.11.13) (Q5F3X1)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004318}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004318}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADVFPGSEPGAAPDAARRFARKGALRQKNVHEVKEHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLLHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTGDKLEVTVREAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTFRSTLNPHWNESFTFKLKPTDKDRRLSVEVWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPDADEDGNAELRQKFEKAKLGPAGNKVITPSEDRNSSVPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKNTEELYAIKILKKDVVIQDDDVECTMVEKRVLALQDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISVGLFFLHNRGIVYRDLKLDNVMLDSEGHIKIADFGMCKEHMLDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGLEGERDIREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPLLENVA
Protein: Inhibitor of four 1 (Predicted gene 4924) (Q1PA39)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDLVTYEDVHVNFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGYKWEDFNIEEHCKCPKRHERSHHL