wanglab/gogpt-training-data huggingface dataset:
Protein: Interleukin-31 (IL-31) (Q6EAL8)
Organism: Mus musculus (Mouse)
Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Interleukin-31 receptor subunit alpha
- Oncostatin-M-specific receptor subunit beta
- Interleukin-13
- Tyrosine-protein kinase JAK1
- Thymic stromal lymphopoietin
- Transient receptor potential cation channel subfamily A member 1
- Interleukin-4
- Transient receptor potential cation channel subfamily V member 1
- Interleukin-11
- Oncostatin-M
Sequence:
MIFHTGTTKPTLVLLCCIGTWLATCSLSFGAPISKEDLRTTIDLLKQESQDLYNNYSIKQASGMSADESIQLPCFSLDREALTNISVIIAHLEKVKVLSENTVDTSWVIRWLTNISCFNPLNLNISVPGNTDESYDCKVFVLTVLKQFSNCMAELQAKDNTTC
Protein: Pebble, isoform E (A8JNN0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLHLPLVQFNFGNHLGKKSNKVVTVQRQSASYFTYAADEEVKQAKLRQAALCQVYEDFTEMSITTLPTRICLVGGVGQDADTLQAAESFGLPIVTSDTGLDILGESSDWRTFYVLDDFEGASFEAIHKQKECILGPPALKYAAEMKQTLGQNSRPIYNYAMRGVVTCFTGIRKKDELTKLVNLIHSMGGCIKKDLNTKTTHLICNHSGGEKYQYAKTFRLTVVRPAWVFAAWADRNSLEFDATQENFTKTHRLKAFEGQKICFFGFPVEEHQHMVDVLLENGGVCAELDDPECSHVVVDEHTTLTKPEPKNNHTHILKSDWFWYTIQNGYANEMDYLFGDYLDSITNTPNTDRRDSLPISFNKRKRKRFSQRIQLEGTPLGSGKRRSSVSDAGLLSVSNSLFDCTTSPDKLESDKLLHAEPEASDATPAKKSMRFNHFMDFYTTESNYVGILDTILNLFKNKLEELAETNDPLLNKSEIKTIFGNFLPIHEVHQSMLEHLRKLHANWREDCLIGDIIIQHRDELIKAYPPYVNFFEQMKEQLQYCDREYPRFHAFLKINQTKPECGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHGRLEEALKAIKQVTLHINEDKRRTESRMAIFDIFNDIEGCPAHLVSSNRSFILKCEVNELSDSLSGRGDSLVLYLFSDSIELCKRRSKGFNTAKSPSTAKTHKHLKLISLNTIRLVIDISDSPRAFGLLLRGDKEKLYTFTISDEETDKSVYVKKLCNQIAAHTCRTDADKLLICRTSQELEVDISDVNVSTLSKAFKLAAKTRLKVGRAFSFNKTPNKLKRAVSTMMTSPFGSTNSLTPASQLAQMRLASCTNINEVDDEDCASMRSSSPSTQSEMLVVPPLSVQPTRKNKAVVGRI
Protein: Protein FAM162A (E9PH05)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGSLSGLRLAAGSCFRLCERDVSSSLRLTRSSDLKRINGFCTKPQESPGAPSRTYNRVPLHKPTDWQKKILIWSGRFKKEDEIPETVSLEMLDAAKNKMRVKISYLMIALTVVGCIFMVIEGKKVRRGFFSIQYVCSPPRT
Protein: Ras-related protein Rab-26 (EC 3.6.5.2) (Q9ULW5)
Organism: Homo sapiens (Human)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:23105096}; Lipid-anchor {ECO:0000269|PubMed:23105096}; Cytoplasmic side {ECO:0000269|PubMed:23105096}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:23105096}; Lipid-anchor {ECO:0000305|PubMed:23105096}; Cytoplasmic side {ECO:0000305|PubMed:23105096}. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. {ECO:0000250|UniProtKB:P51156}.
Interaction partners:
- Autophagy-related protein 16-1
- Rab proteins geranylgeranyltransferase component A 2
- Geranylgeranyl transferase type-2 subunit alpha
- Geranylgeranyl transferase type-2 subunit beta
Sequence:
MSRKKTPKSKGASTPAASTLPTANGARPARSGTALSGPDAPPNGPLQPGRPSLGGGVDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDGVKVKLQMWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKASFDNIQAWLTEIHEYAQHDVALMLLGNKVDSAHERVVKREDGEKLAKEYGLPFMETSAKTGLNVDLAFTAIAKELKQRSMKAPSEPRFRLHDYVKREGRGASCCRP
Protein: Homeobox protein engrailed-2 (Homeobox protein en-2) (Hu-En-2) (P19622)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MEENDPKPGEAAAAVEGQRQPESSPGGGSGGGGGSSPGEADTGRRRALMLPAVLQAPGNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGGRGGGAGGEGGASGAEGGGGAGGSEQLLGSGSREPRQNPPCAPGAGGPLPAAGSDSPGDGEGGSKTLSLHGGAKKGGDPGGPLDGSLKARGLGGGDLSVSSDSDSSQAGANLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHSTTAKEGKSDSE
Protein: Heat shock protein, putative (EC 1.3.1.74) (B9RYP6)
Organism: Ricinus communis (Castor bean)
Interaction partners:
- Heat shock 70 kDa protein, putative
- Endoplasmin homolog
- Heat shock protein binding protein, putative
- Calnexin homolog
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Hsp70-binding protein, putative
- Sil1, putative
- Calreticulin
- Calreticulin
Sequence:
MAGSWRARGAVVSAIVLFGCLFAISIAKEEATKLGTVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVAFTDSERLIGEAAKNQAAVNPERTIFDVKRLIGRKFEDKEVQRDMKLVPYKIVNKDGKPYIQVKIKDGETKVFSPEEISAMILTKMKETAEAYLGKKIKDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKRGGEKNILVFDLGGGTFDVSILTIDNGVFEVLSTNGDTHLGGEDFDQRIMEYFIKLIKKKHGKDISKDNRALGKLRREAERAKRALSSQHQVRVEIESLFDGVDFSEPLTRARFEELNNDLFRKTMGPVKKAMEDAGLQKNQIDEIVLVGGSTRIPKVQQLLKDYFDGKEPNKGVNPDEAVAYGAAVQGGILSGEGGDETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIQVFEGERSLTKDCRLLGKFDLTSIPPAPRGTPQIEVTFEVDANGILNVKAEDKGTGKSEKITITNDKGRLSQEEIERMVREAEEFAEEDKKVKERIDARNSLETYIYNMKNQISDKDKLADKLESDEKEKIETAVKEALEWLDDNQSAEKEDYEEKLKEVEAVCNPIITAVYQRSGGAPGGGSTEEDDSHDEL
Protein: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) (P00361)
Organism: Thermus aquaticus
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MKVGINGFGRIGRQVFRILHSRGVEVALINDLTDNKTLAHLLKYDSIYHRFPGEVAYDDQYLYVDGKAIRATAVKDPKEIPWAEAGVGVVIESTGVFTDADKAKAHLEGGAKKVIITAPAKGEDITIVMGVNHEAYDPSRHHIISNASCTTNSLAPVMKVLEEAFGVEKALMTTVHSYTNDQRLLDLPHKDLRRARAAAINIIPTTTGAAKATALVLPSLKGRFDGMALRVPTATGSISDITALLKREVTAEEVNAALKAAAEGPLKGILAYTEDEIVLQDIVMDPHSSIVDAKLTKALGNMVKVFAWYDNEWGYANRVADLVELVLRKGV
Protein: Actin-binding protein WASF1 (Protein WAVE-1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) (Q8R5H6)
Organism: Mus musculus (Mouse)
Function: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. Also involved in the regulation of mitochondrial dynamics (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q92558}. Synapse {ECO:0000269|PubMed:24153177}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q92558}. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas. Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2. In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (PubMed:27605705). {ECO:0000250|UniProtKB:Q92558, ECO:0000269|PubMed:27605705}.
Interaction partners:
- Cytoplasmic FMR1-interacting protein 1
- Abl interactor 2
- Nck-associated protein 1
- Abl interactor 1
- Cytoplasmic FMR1-interacting protein 2
- Nck-associated protein 1-like
- Protein BRICK1
- Actin-binding protein WASF2
- BAR/IMD domain-containing adapter protein 2
- ABI gene family member 3
Sequence:
MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKQKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDADLLHKHIEVANGPASHYETRPQTYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPTPTCISSATGLIENRPQSPAAGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVAVAALAHPPSGLHPAPSTAPGPHAPLMPPSPPSQVLPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE
Protein: AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3) (Q9DCH6)
Organism: Mus musculus (Mouse)
Function: Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1 (By similarity). Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Peroxisomal ATPase PEX6
Sequence:
MAQETNHSQAPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPAASVSSLSESLPVQCADGSVPDAQSALDSTSSSMQPGPVSNQSLLSESVAPSQVDSTSVDKAVSETEDLQGPRAEGLVPLECDPPSSVSDTTQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI
Protein: DSC E3 ubiquitin ligase complex subunit 3 (Defective for SREBP cleavage protein 3) (Q9HE10)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein. Golgi apparatus membrane {ECO:0000269|PubMed:21504829}; Multi-pass membrane protein.
Interaction partners:
- DSC E3 ubiquitin ligase complex subunit 2
- DSC E3 ubiquitin ligase complex subunit 4
- DSC E3 ubiquitin ligase complex subunit 1
- UBX domain-containing protein 10
- Putative ERAD-associated E3 ubiquitin-protein ligase component
- Mannan polymerase II complex anp1 subunit
- ERAD-associated E3 ubiquitin-protein ligase hrd1
- Uncharacterized derlin-like protein C365.08c
- Putative transcription factor sre2
Sequence:
MSSSALKKWEIVIRFASSIPDLSLEISDAQTTTIHSLFKIVRNRIPECRDKQLKMVFQGRLLSPGFTVERAVRGNWQRDENDDPNIVQKAFIHCIVGPTLTEEELASQDQAQSGLNSNSESPDDLQNAQTGETLRGFDRLREAGFTETEVNNLRSQFHRLRGTNLDSLTEDAIREAEDDWIDNGGQNSSADELDMSYETLLAGVLIGFFGGAIACYFLWERTMFSLRMQLSILVGIICNFAYGLLHSYRW
Protein: Peptide deformylase (PDF) (EC 3.5.1.88) (Polypeptide deformylase) (P9WIJ3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
Interaction partners:
- Probable histone acetyltransferase Rv0428c
- Probable exodeoxyribonuclease III protein XthA
- Methionine aminopeptidase 2
- Trigger factor
- Large ribosomal subunit protein bL21
- Methionyl-tRNA formyltransferase
- Small ribosomal subunit protein bS20
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein bL9
- Large ribosomal subunit protein bL17
Sequence:
MAVVPIRIVGDPVLHTATTPVTVAADGSLPADLAQLIATMYDTMDAANGVGLAANQIGCSLRLFVYDCAADRAMTARRRGVVINPVLETSEIPETMPDPDTDDEGCLSVPGESFPTGRAKWARVTGLDADGSPVSIEGTGLFARMLQHETGHLDGFLYLDRLIGRYARNAKRAVKSHGWGVPGLSWLPGEDPDPFGH
Protein: ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) (Q63087)
Organism: Rattus norvegicus (Rat)
Function: Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Early on in development, it plays a role in forebrain mesenchyme survival (By similarity). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12390248, ECO:0000269|PubMed:12929931}.
Interaction partners:
Sequence:
MEFLSEKFALKSPPSKNSDFYMGTGGALEHVMETLDNESFYGKATAGKCVQAFGPLPRAEHHVRLDRTSPCQDSSVNYGITKVEGQPLHTELNRAMDGCNNLRMSPVKGMPEKSELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNTSGGSVVTSCMLPRDASSCMTPYSHSPRTDSSYTGFSNHQNQFGHVPLNNFFTDSLLTGTTNGHAFETKPEFERRSSSIAVLRMKAKEHTANISWAM
Protein: LD35343p (Q8T032)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQTPHCGEAITTTMATSSSTISEPVNSVTVDGQHNEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAAAATATSLESPVATTASSSTTLFPTPTPFDFDYDIMRDEAQQSSPNIHDVSKALSDNASSSCPINESYKLLSTTALETSPAKGLRSNSRLHRSSIHICKLCNQTFDELGKLVKHEMELHSNTERSRWGYQHKCAICNTSYRTLTLLKFHMKRHSNRKSQCKLCPKSFVTIAELERHTKAKHSKDKTLRCFMDGCRKTFAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEITYKCPKCDRSYLRRGRLVTHALIIHDLRFTTEELGNLSSLATNQARPNDLKVATPVGLLDGRKDVSGASEENGQP
Protein: Septum site-determining protein MinD (Cell division inhibitor MinD) (Q01464)
Organism: Bacillus subtilis (strain 168)
Function: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity).
Subcellular location: Cell membrane; Peripheral membrane protein.
Interaction partners:
- Septum site-determining protein MinC
- Rod shape-determining protein MreD
- Cell shape-determining protein MreC
- Cell shape-determining protein MreB
Sequence:
MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLRNLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQIKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLLEQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGEPIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS
Protein: VUT family protein (E7DND6)
Organism: Pneumococcus phage Dp-1 (Bacteriophage Dp-1)
Interaction partners:
Sequence:
MVKKLKSKIYSVAYIILVVIANLVTIYFEPLNVKGILIPPSSWFMGFTFLLINLISKYEKPKFAGSLIWVGLFLTSLICFMQNLPQSLVVASGVAFWISQKASVFIFDKLSNKLDSKIANALSSNIGSIIDATIWISLGLSPLGIGTVAYIDIPSAVLGQVLVQFILQSIASRYLKK
Protein: Protein XRI1 (Protein X-RAY INDUCED 1) (Q6NLW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for mitotic division of the generative cell nucleus and the development of mature tricellular pollen grains, and for male and female meiosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:19187040}.
Interaction partners:
- MND1-interacting protein 1
- Maternal effect embryo arrest 18
- Ribonucleoside-diphosphate reductase small chain C
- DNA repair protein RAD51 homolog 1
- Meiotic nuclear division protein 1 homolog
- Thymidine kinase a
- Cyclin-dependent protein kinase inhibitor SMR5
- Protein BREAST CANCER SUSCEPTIBILITY 1 homolog
- Homologous-pairing protein 2 homolog
- BRCT domain-containing protein At4g02110
Sequence:
MDYGDDDRSSSWNWQVDNYNHQPQSHFSDVPDCTMTEVTLNQEDHSYMFDDENTPVKACSELGYHVTTEDTNRKMEVHSETRSALKRRRMLQFEDQPETSLFSSESFSAILKSSARDDTFDELLPEGSQLIEGFSEDASASSFEGLDLYAEEWYADCLNDAETPMLPDDLNFGSPDVQVDISEYLNVPPETETREVQRPVTRSSPNVIFKGRKSFSRPVSKLPSSIIYPFAFIKPCGVHGGMTLKDINQKIRNPPAKPKAHIEEPAVIQTSAFSGKPVVGKTKIRTEGGKGSITIMRTRG
Protein: Alpha-1,6-glucosyltransferase (alpha6GlcT) (EC 2.4.1.-) (Polymerizing glucosyltransferase) (B3H2N1)
Organism: Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Function: Catalyzes the transfer of a glucose moiety from UDP-glucose to another glucose that is N-linked to an asparagine within a peptide or protein. Can act in a repetitive manner, and this way it elongates the N-linked glucose by a glycan chain consisting of several alpha-1->6 linked glucose residues. Is able to add up to six glucose units in vitro. Cannot use UDP-Gal, UDP-GlcNAc or UDP-GalNAc as a substrate donor.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:21852240}.
Interaction partners:
Sequence:
MENNIDLNVYFCFVNRPCTGGDFVNLDHVRTLRKLGINASILLAGNQSEEIVNSFGSLPVVILNEEIEFSSQDIFIVPEVMQVLYDLASKMTVFPRMIMHNQNPFYTGYGFLSAQHINEHRLERIIVPSSYTKYKLQEIGVTKPIDIIHPYIPDYFKPAEKQREVIQIAFSRRKRSAEFDIFKFYFLSLYSHKHSVNFVNIQGLTREEVAKVMSEAAIFISFAERESLGLMTLEAMASGCHVIGFSGYTDIYNNEVIDDSVGDWIGEGEYTLFAQKVCQAIDDFVNGKMNPKIENGLRLIEQRFRIRHFEQEVKRVYGNIFDYDLENSRS
Protein: RNA-silencing factor ers1 (O94717)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in RNAi-dependent heterochromatin formation and centromeric silencing. Required for the conversion of centromeric pre-small interfering RNA transcripts into small interfering RNAs, histone H3 'Lys9' methylation, and the recruitment of the RITS complex to centromeric sequences.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MGKVSANNQSGFFKFYIDTALLLNAEFISSFTNCINSEYNGKVKISYSSSSQQFKVIVYEEHKREAFSLFEEIVQKLKRESTVYKKPRLDIHPFGQLHYDFTTLLNFQRYLDLGYGIEDVKIKENEDIVKSKVGKKPTSSDFYIPCLIKPKIITPFEWEGNFKQVIYSPTVYNGSFKRLFYLPDNNDLLKEFAHATNTKYKASLKDNKIVVLANNDQDINAMLEKMKHIENLVSQKVYEYPEETLVYAGKIAPCQLKFLKLKFENEILYTAMHTTSIFKSVFNILGSFYTMRLLRNKHDGDSYELVPVFAKNPSKTPPCNDNFKIFSDDIKLIGCKIFAGVSLNFSSPKPAHRFYELNKTSSNLSIPVLQKPSNFHSSSTELSDNSIHQGRRAVDPVVNQNNPSNFEEMIMNKLNKLPTIDKQILGTSSLTHFQDKTTAIEHSINKSNSKQPPRFKFQLPPRPTSNTLPLEPEEELVTRYSVSSDGNTVDEAITKQSQTFQLVNSNEFNEVNANDVHKSLRQNCAKLDFDDSKSKNLLSVECLELDKGSDCSTPKSGSLTPSIDMKFLRLQDEKMDDLGDNYYTILMSSNPVSSYGVGSLYLFQPKIVCSEKYINHEEIDNMNLKSLHRWLSRSLHVLQSFSGEIELNLEFGVILYPNISSDVSACSHGFMNIYKDLNLPRSYFADCITKSVSNIDSLLNTPVKILFGRTEYTYPLIEHEVLDSKNYFVFKGSLLFTDDKRNKTEDSTVFFSMICSSKLDQFAFYKDSKQSSTCTINFPLALWDSRLRIETKVPLNDAILTEFSKSIRFRNVNKDLLLVFGNMEDRVIIHSVTRINENSVPFNKNLLPHSLEFILKCSKVKSYDISPSSINSKEAFVCLDRSKESKPIESCFSLSIQSVYMQSQFKYNNSIRAGETAPWKLANKQFIGGAITENVSDLYTAAIIMVNQLGGIHPTI
Protein: N-acetyltransferase, putative (Q57XN8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Mak10 subunit, NatC N
- Small nuclear ribonucleoprotein E
- Sm protein B
- N-acetyltransferase, putative
- N-acetyltransferase subunit ARD1
- N-acetyltransferase complex ARD1 subunit, putative
- N-acetyltransferase B complex
Sequence:
MPKKGKKNATKNNVKDVDIDALVAAIEGTSVPSKNSKEGMTRKQAMALEEKQMEEVLTKPVAAAQPLVDEHRLRMSLLAERLMHEKAIRDAEVAKALVPLKEEEKAWQKVSDNKYIRYEQFDGDEEVMNFIVQLFTKELTEPYSSFTYEYFIFGWPDLTIVAYGYDGEDVPDASVKGKRVGAVVSRVSRKHIDSPLRGYVAMFAVIPEFRGFRLGSRLVTLTIELMREKGCDEVYLETPTNNERALSLYLNLGFAKSKFLPRYYLDHSDAVRLKLWLKDPPFCTPVQPATPAVAVAAAASPSTSTSPI
Protein: RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (X6RLP6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAPEQPLAISRGCTSSSSLSPPRGDRTLLVRHLPAELTAEEKEDLLKYFGAQSVRVLSDKGRLKHTAFATFPNEKAAIKALTRLHQLKLLGHTLVVEFAKEQDRVHSPCPTSGSEKKKRSDDPVEDDKEKKELGYLTVENGIAPNHGLTFPLNSCLKYMYPPPSSTILANIVNALASVPKFYVQ
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (Q93931)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Probable complex I intermediate-associated protein 30, mitochondrial
- Uncharacterized protein B0035.15
- Probable NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase iron-sulfur protein 3
- NADH dehydrogenase 1 beta subcomplex subunit 10
- Complex I assembly factor TIMMDC1, mitochondrial
- Probable NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- Probable NADH dehydrogenase iron-sulfur protein 2, mitochondrial
Sequence:
MNKSLIALGAQTARRFLSSSSKNTIGGGDANRADTGVLDGYHINPLEESDMTDRSRISMLSTEMLEAKQIGVRGLSCYGFRLLDGTFLYGPIALFPKTALSWRVPTPEDITPRSLALFAALEPKIDILVLGVGDKKNIDKVRASVAPFLREHKIGLEIMDTEDAIATFNFLNAEGRYVGAALYPPDDMVVTDKEYGRALALLKGWDTVEENPLLTGLSDTINGAEDLVKRLWSGDEKSWQSARQKVLESPSEREERMQQEMNDKEKKRIE
Protein: E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) (V9HW41)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
Protein: Cdh1p (Q5ACY4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Anaphase promoting complex subunit
- Anaphase promoting complex subunit
- Anaphase promoting complex subunit
- Anaphase promoting complex subunit 1
- Anaphase promoting complex subunit
- G2/mitotic-specific cyclin CLB2
- Serine/threonine-protein kinase
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 2
Sequence:
MDKRDSNRPSKDNAIRNPFVSFETPRSPSRSTRSLNPPKLNEMGAIQSSPPRRRNNNTIFSDRYIPNRTGVDLQAAFSLTNEEILPDLRNTRNADNEIEIRREEEANRTFSTVLKAELFGDNVPMATANLSSATANSNLANNRSKTGRTNTGIVNGASVSGAATSTSSLSTTPPRSSNSGQNFPGSTGSSLPGNNNAIGNNDSHNIISANANNNISSDIDDITSTPRRKTNLFTYQSPQKSKPISRDLQQELYSLSPVRQDSQKLLLSPQKKPRTISKVPYRVLDAPELSDDFYLNLVDWGQQDVLAVGLGDSVYLWDGATQSVDRLCNLTNKDKVTSLNWIGTGTHLAIGTSKGLVEIWDATRIKCIRTMTGHSLRVSSLAWNEHILSSGSRDRTILNRDVRIEDHFVNKFDNHKQEVCGLKWNVEENKLASGGNDNNLFVWDGLNPKPLHQFTDHTAAVKAIAWSPHQRGILASGGGTADKTIKTWNTLTGNLVHDVNTGSQVCNLIWSKNSNELVSTHGYSRNQIIVWKYPSMQQIAQLTGHTYRVLYLSLSPDGETIVTGAGDETLRFWNVFEKNRHNESPASVLLGAFSQLR
Protein: 34 kDa antigenic protein homolog (P9WIR9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein Rv0955
- Uncharacterized protein Rv0953c
- Small ribosomal subunit protein uS9
- Bifunctional purine biosynthesis protein PurH
- Electron transfer flavoprotein subunit alpha
- Phosphoribosylglycinamide formyltransferase
Sequence:
MTYSPGNPGYPQAQPAGSYGGVTPSFAHADEGASKLPMYLNIAVAVLGLAAYFASFGPMFTLSTELGGGDGAVSGDTGLPVGVALLAALLAGVALVPKAKSHVTVVAVLGVLGVFLMVSATFNKPSAYSTGWALWVVLAFIVFQAVAAVLALLVETGAITAPAPRPKFDPYGQYGRYGQYGQYGVQPGGYYGQQGAQQAAGLQSPGPQQSPQPPGYGSQYGGYSSSPSQSGSGYTAQPPAQPPAQSGSQQSHQGPSTPPTGFPSFSPPPPVSAGTGSQAGSAPVNYSNPSGGEQSSSPGGAPV