wanglab/gogpt-training-data huggingface dataset:
Protein: Bifunctional dihydrofolate reductase-thymidylate synthase (Q8I1R6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Serine hydroxymethyltransferase
- Thymidylate kinase
- Aminomethyltransferase, mitochondrial, putative
- Dihydrofolate synthase/folylpolyglutamate synthase
- Methionyl-tRNA formyltransferase, putative
- Ribonucleoside-diphosphate reductase
- Inosine triphosphate pyrophosphatase
- Enoyl-acyl carrier reductase
- Serine hydroxymethyltransferase
Sequence:
MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKNVDKYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA
Protein: RE63915p (Q8MT32)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSLDARNNSAMMKRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDEVVQLLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANKRNKRRPSSQIRISDAMENHVEKTPTKLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPTNDQVPDRELGTNSSETANDVILRRTQSFENDQKKPTVTIATSTAATAINSPSTTVQTPPIRSQVTAKIAEKSNNGSSSTASVSDAESSKPPPKQSASNMIKNFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGMANNNNNNNISTTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDELQPPPPPTTPPPAVIPTTTTATDETEIEEVVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADANSDPEGDQDQTVVSASYTIMPRRERLPESSENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLPLIPAPAAPSTEAIKSSSAATTPAALESPVRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYARRTTDSSAGGGGVGGGAGVGAGGASGAATSSSTSAAERRPSWRLKFDAGSKFKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQTVIQRRRKPKRRSTGVVHIDMDELDPERQNESSNNDNEEKEKESGSERTSRSRLGSTASTATTSESKSSSSNDKTENGDGIDYKALWEAEKLENDKLRQMLKQKDDEAVQTRATLERFANATTKNSLSELEKRERRAMERKLSELEEELKQLDAYKSDNHRLKEENAALIRVISKLSK
Protein: GEO10172p1 (IP02765p) (IP02768p) (Mitochondrial ribosomal protein S18C) (Q9VA81)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein mS33
- Small ribosomal subunit protein mS40
- Mitochondrial ribosomal protein S11
- Large ribosomal subunit protein mL66
- 28S ribosomal protein S14
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS15m
- Mitochondrial ribosomal protein S23
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein mS29
Sequence:
MLKLGKFLAQNATLVNLVGRQQLGTVSRLYSAAPESSDLDLPIDIKNPYEKDPQQCILCKHSIEPHYKNVKLLSQFQSPYTGRIYGRHITGLCKRRQEQVEQAILRAQQCLLMPGYHKDLDFLQDPKLFDPERPVRPHKY
Protein: RILP-like protein 2 (Rab-interacting lysosomal protein-like 2) (p40phox-binding protein) (Q969X0)
Organism: Homo sapiens (Human)
Function: Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). May function via activation of RAC1 and PAK1 (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:14668488}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Ras-related protein Rab-8A
- Ras-related protein Rab-10
- Unconventional myosin-Va
- Ras-related protein Rab-12
- Ras-related protein Rab-36
- Ras-related protein Rab-7L1
- Protein phosphatase 1H
Sequence:
MEEPPVREEEEEEGEEDEERDEVGPEGALGKSPFQLTAEDVYDISYLLGRELMALGSDPRVTQLQFKVVRVLEMLEALVNEGSLALEELKMERDHLRKEVEGLRRQSPPASGEVNLGPNKMVVDLTDPNRPRFTLQELRDVLQERNKLKSQLLVVQEELQCYKSGLIPPREGPGGRREKDAVVTSAKNAGRNKEEKTIIKKLFFFRSGKQT
Protein: D-galacturonate reductase (EC 1.1.1.365) (D-galacturonic acid reductase) (Q3ZFI7)
Organism: Hypocrea jecorina (Trichoderma reesei)
Function: Mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. Also has activity with D-glucuronate and DL-glyceraldehyde. No activity is observed with D-glucose, D-fructose, D-xylose, D-galactose, L-arabinose or D-mannose. Activity is seen only with NADPH and not with NADH.
Interaction partners:
Sequence:
MVATSFKLNNGLEIPAVGLGTWQSKAGEVKAAVSYALQIGYKLIDGAYCYGNEDEVGEGLKEAFAAGVKREDIFVVTKIWATYNTRVVLGLDKSLRSLGLDYVDLLLVHWPVLLNPEGNHDKFPTLPDGKRDVIWDYNHVDGWKQMEAVLATGKTKSIGVSNYSKKYLEQLLPHATVIPAVNQIENHPSLPQQEIVDFCKEKGIHIMAYSPLGSTGSPLMSADPVVKIAEKKGISPTTVLLSYHVNRGSTVLAKSVTPARIKANLEIVDLDDEDMKLLNDYSNDLASKGELKRYVYPPFGIDFGFPDKS
Protein: DNA replication complex GINS protein SLD5 (Q9VBI1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR007764}.
Interaction partners:
- DNA replication complex GINS protein PSF1
- Chromosome transmission fidelity 4
- DNA replication licensing factor Mcm7
- DNA replication licensing factor Mcm6
- DNA replication licensing factor Mcm2
- DNA replication licensing factor MCM4
- DNA replication licensing factor Mcm3
- DNA replication licensing factor Mcm5
- DNA replication complex GINS protein PSF3
- Probable DNA replication complex GINS protein PSF2
Sequence:
MSDVEDVPETQLEIDVSDGAGLEDEDDDDMEQITAQKVLEIIETAWINEMCAPEILPSQTDMLELMVSQVAHMEEQMRDLDKNDFRAVVHSMELERVRYIMASYLRCRLQKIETFTQHILNQEESREPDDKRLSPEETKFAQEFASNVDEYFHKVATQYMPNQQRGEAEQRIVTPNLMSHVFLKANVAVPAVIVGVDDEEVDMAAGSQHIIPYQLVADLIQNNQAQLI
Protein: Sec-independent protein translocase protein TatC (Q9HUB3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00902}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00902}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Sec-independent protein translocase protein TatB
- Sec-independent protein translocase protein TatA
- Sec translocon accessory complex subunit YajC
- Protein translocase subunit SecA
- Ribosomal RNA small subunit methyltransferase E
- Protein-export protein SecB
- Protein translocase subunit SecF
- Phosphoribosyl-ATP pyrophosphatase
- Phosphoribosyl-AMP cyclohydrolase
Sequence:
MSADKPEQPEHDQEMPLVSHLTELRTRLLRSVAAIFLIFAGLFYFSQKIYTLVSEPLRRFLPEGTSMIATDVASPFLAPFKLTMVVALFLAMPVILAQVWGFIAPGLYKHEKRVALPLLVSSIILFYAGMAFAYFLVFPMIFHFFASVTPEGVAMMTDINSYLDFVLTLFFAFGVAFEIPVATVLLIWIGVVDVDYLKKIRPYVIIGCFVVGMVLTPPDIFSQTMLAVPMWLLFEIGLLFGRLVRKRGEHPDDQPASDGDQPPATRQ
Protein: Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Q389C2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Transketolase
- 6-phosphogluconate dehydrogenase, decarboxylating
- Ribose 5-phosphate isomerase, putative
- Transaldolase
- fructose-bisphosphatase
- Glucose-6-phosphate 1-dehydrogenase
- fructose-bisphosphatase
- Methylthioribose-1-phosphate isomerase
Sequence:
MVHRQDGAVVHCSRETGRLSAIIAPSILASDFAQLLSECQSVLSPEGGAADWLHVDVMDGHFVPNISIGMCVVQSLRSHLQDVFLDVHCMVSDPDRWVEEMAKAGATQMTFHVEAVADPKAVARHIRAAGMLCGVALKPKTPVSSVLNLVEEQLIDMVLVMTVEPGFGGQSFMQDMMPKVEELRARFPCLNIQVDGGIGPGTIDAPARAGANVIVAGTSIFRADSRKEATESMRRVVQGYLGSTTS
Protein: Proline rich transmembrane protein 2 (A0A1B0GTE9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAASSSEISEMKGVEESPKVPGEGPGHSEAETGPPQVLAGVPDQPEAPQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESKANCSPEDPCQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGAVVPLQAGDGEEGPAPEPHSPPSKKSPPANGAPPRVLQQLVEEDRMRRAHSGHPGSPRGIPEQPAAGGRGRGPASGPGSQALKHRGAGGGSPHHHRLLRHQLRRV
Protein: Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) (E9PS30)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSQATKRKHVVKEVLGEHIVPSDQQQIVRVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGE
Protein: Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (D3Z8D9)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- DNA polymerase zeta catalytic subunit
- DNA polymerase delta subunit 2
- DNA repair protein REV1
- Shieldin complex subunit 2
- Mitotic spindle assembly checkpoint protein MAD2A
- DNA polymerase delta catalytic subunit
- DNA polymerase epsilon catalytic subunit
- DNA polymerase alpha catalytic subunit
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Fizzy-related protein homolog
Sequence:
MTTLTRQDLNFGQVVADVLSEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSINSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKNS
Protein: Transcription factor MYB52 (Myb-related protein 52) (AtMYB52) (Protein ABA-HYPERSENSITIVE 1) (Q6R0C4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that confers sensitivity to abscisic acid (ABA) and salt, but tolerance to drought. Regulates secondary cell wall (SCW) biosynthesis, especially in interfascicular and xylary fibers.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:18952777}.
Interaction partners:
- NAC domain-containing protein 10
- NAC domain-containing protein 73
- NAC domain-containing protein 12
- Homeobox protein knotted-1-like 7
- NAC domain-containing protein 66
- NAC domain-containing protein 43
- NAC domain-containing protein 30
- Pectinesterase inhibitor 6
- NAC domain-containing protein 104
- NAC domain-containing protein 37
Sequence:
MMCSRGHWRPAEDEKLRELVEQFGPHNWNAIAQKLSGRSGKSCRLRWFNQLDPRINRNPFTEEEEERLLASHRIHGNRWSVIARFFPGRTDNAVKNHWHVIMARRGRERSKLRPRGLGHDGTVAATGMIGNYKDCDKERRLATTTAINFPYQFSHINHFQVLKEFLTGKIGFRNSTTPIQEGAIDQTKRPMEFYNFLQVNTDSKIHELIDNSRKDEEEDVDQNNRIPNENCVPFFDFLSVGNSASQGLC
Protein: Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) (Q7ZUV2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9BVA0}. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles. {ECO:0000255|HAMAP-Rule:MF_03022}.
Interaction partners:
- Katanin p60 ATPase-containing subunit A-like 1
- Katanin p60 ATPase-containing subunit A1
- Katanin p60 subunit A-like 2.
- Abnormal spindle-like microcephaly-associated protein
- Fidgetin
- Katanin p80 subunit B-like 1.
Sequence:
MALTNTTITSWKLQEIVAHSSNVSSLVLGKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYSGSENTLRVYGWEPDRCFDVVHVGWGKVSDLAISNNQMIAVSYSHTNVSWYVVDLNRVKKSGSVIQGLIQDKPIPAPSSALGTTLRRNYERPTTSCTGQEMKQSSEADRRSPEGERRSPSSEDEKEDKESSAEITNPEDYKEIFQPRSVISRTPPKTTEPFPAPLEHSFSESVLEKPGPVVKIVTPVIDRAGQLKGPITSSTPVQRVEPTVIAAAPRPVAVVTTSASSPSRPVVNTTKPKPSTGIILSTRNEPIGLNAGDFLSHARNAKASAMGDEEALAQIRKGHDTMCVMLSSRSKNLDSVRSVWASGDVKTSLDSAVSMNDLSIVVDVLNIINLKPSLWKLDLCTSILPQIEELLQSRYESYVQTGCMSLKLILKRFWPLISDTLNAPPSVGVDITREERHQKCKACYKQLKNLSNVVKNRAEQVGRHGSTFRELQLLMAPLDY
Protein: Protein ABERRANT POLLEN TRANSMISSION 1 (K7VLR4)
Organism: Zea mays (Maize)
Function: May be involved in membrane trafficking. Required for tip growth in pollen tubes and root hairs.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q6IMT0}. Golgi apparatus {ECO:0000269|PubMed:16299389}.
Interaction partners:
- Translation initiation factor IF-2 chloroplastic
- Translation initiation factor IF-2
- Ribosomal protein S24/S35 mitochondrial
- Small ribosomal subunit protein mS29
Sequence:
MMLGLVQLLVGFVVAWEAVELVLRHGLLLSVFKLAILAALAAAAGCVAIIFFARAVAWVLQRAAKLSIGCRSYGFNYLRDITISSPKGAVESICIGEIRLGLRKPITQLGFTVLTHGPILQLQISDLDVVLRQPVKSTNKKKPAPRKPISTTTAKAKGKSKGQVKWRLITSMASLLSLSIVELRLKAPKAALGIKDLKTDISKTGGLDPVLNVQVNIIPLFVQALDSDSIGNNTLVFSKLDWWVSGQYCSAMDTSDHSSFLFEDISLSCDLHQRDKAIRVKNLDLMLGPIVVNLEEKLLAKKKPSASTVAEQKDEPSVDNKSAARSEGGKLASLNKKISMFPEKVSFNMSKLVLKFLPKDHGLSINNEIGSISLRCTRLQPQDFGEVTTHIRLETDVTEIHLLMDGATSVLEVVKVSTVVSANIPSQPALPVQAEVDIKISGFQCNLIVSRIKPLIRINSDKKKPLVLHENPQQKKAPKEKLALSLACTMSVPELTLVLHSLDDVPLYHCIFQSANVSASKMIDRGTQLHGKLGDLKFLVPSKHQQSMKEGASGTLLHISHSTLDLEQNDPGQDNDEDHAKSAISVNISGIRMHFCFSYLESLCATAMSYKVFMKSILPPKKRSVQENASQKSTKKAKRALLLKINVAQCSIVYDGEMRLEDMSIADPKRVNFGSQGGRVVIINEANGSPRMAYVNSTSLPDHKNVHFSTSLEIYQFGVSLNKAKHTMQVELENFRLTHKEDQLDNKPVEETKLFDVRKAKFVQRSGGLNDIAACSLINVTDIAVRWEPDPYLELLEVATRLKSVLHRMKLQNSVTEVKDNIEHGYSFQKGITLRPWSARKAQKKRESVIAIDLESLKISGELADGVEAMITVGYIFSENAKIGVLVEGISVSFCGAWILKSSRMQLSRIPISVSDSNSDKKLQSAAACDWVIQCRDVNICLPFRLQLRAIDDAVEDTLRAFKLISAAKTSVLFPEKKSSTTSSKKSKPKSTAFRYVRIIVRDLIAEIEEEPMQGWLDEHMILMKNVFCESTVRLNLLDELSSGKNKDSPKAKLDSSEKNSGCPDVDAYVPGTHSIEKLREEIYRQAFQSYYQACQKLPVSEGSGACSSGFQSGFKMSTRRASVMSVCAKDVDVSLSKIDGGDEGMISFIKSLDPVCDKDDIPFSRLYGSNFSLKTRSLSAYLRDYTFPLFSGTNGKCDGRLVLGQQATCFQPQARQDVYVGKWWRVNLLRSATGYTPPMKTYADIPLYFKKAEVSFGVGYEPVFADVSYAFTCALRRANLAKRWYFERPEPPRRERSLPWWDDMRNYIHGKFKLCFNETKWHLPASTSPYEKLDELLIITDFMEIHYVDGYVSLSSKYLRVYLTSLESLAKKSSLEIPHHPAIPFLETPSFFMDISIEWGCDSGNPMDHFIFALPAEGKPRDKVFDAFRSTSLSLKWSFSLKPYTTEPIEHQKKSNLNTTAPTVNVGVHDLAWLMKWWNLVFLPPHKLRLFSRFPRFGVPRFVRSGNLPLDRVMTEQCIRFDAMQLQINNMPLQADDPAKGLTLHFTKFRYEIAFSRGKQIFTFDCKREPLDLVYQGIDLHLLKVFINRIPESSTSMDSKIENKVLQTKDKDSLGCEKGKKKTSPTEKSRDDGFFLYSDYFTIRKQTPKADAARLSAWQEDGRKKTEMPLIKSEFDGGDESDHDQSGSDDEGFNVVVADSCQRVFVYGLKILWNLENRAAVLSWVGGLTQAFQPPKPSPSRQYTQTKILEKKQLIKEAEMSKDGALSSVSSTSQPSEPQQIKSSESPPSNGSGKPDLTSSSENALKRSNNSDSEEEGTRHFMVNVVQPQFNLHSEEANGRFLLAAGSGRVMVRSFHSIVQVGQEMFEKAIGSSNDATGGTGPEMTWSRVELSVMLEHVQAHVAPTDVDPGAGIQWLPKIHRRSSEVKRTGALLERVFMPCQMYFRYTRHKGGTPELKVKPLKELTFNSPDITAGMTSRQFQVMMDVLTNLLFARTPKKPKSNLSYPLDNDDDNIEEASDAVVPDGVEEVVLAKIGVEVKERARKLLLDDIRALSICGETSHGQSQSPKANDIAWIVTGSRLMLVKQLKKRLVNVRNGRKEAYSMLRTAMQKAAQLRLMEKEKNKSPSFAMRISVRIKKIVWSMLADGKSFSEAEINDMIFEFDRDYKDIGIAQLTTKLFVLKNGLANAKSDTVVSPWNPPAEWGKNAMLRVNAWQGAPTGGNPVIESFLVDIYPLKIYLTEAMYRMMWGYFFPGDEQQPQKRQELFKVSTTAGTRRKKNTSVAETNSPNNQSSKETTFAQKPELRRTSSFDRTWEETVAESVANELVSQMEGQTNTQYEPQDAAKDSKLLRPVRSTREDKKIVEPNELKQSRPQKMMDFRNIKISQVELQLTYEGLPFAVSDVRLLMDTFHREDFTGTWARLFSRVKKHIVWGVLKSVTGMQGKKFKAKSSSQKEPSTALISAADFNLSDSDGDEAGSSDQLPAFLKKPSDGAGDGFATSVKGLFSTQKKKAMAFVLKTMKGDADHDFHGERSENEIEFSPFARQLTITKTKKLIRRHTKKLNKSKVHKVTATELEVAELPPRAPGYNTDSSSDSSSAETSPKD
Protein: HTH-type transcriptional regulator HexR (Hex regulon repressor) (P46118)
Organism: Escherichia coli (strain K12)
Function: Represses the expression of the hex regulon (zwf, eda, glp and gap).
Interaction partners:
- Glucokinase
- KHG/KDPG aldolase
- Phosphogluconate dehydratase
- Uncharacterized protein YfdI
- Glucose-6-phosphate 1-dehydrogenase
Sequence:
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAAMALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTPYVNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINRAVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYSDDIVLQRMSCMNCSDGDVVVLISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSRLAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKQLLNLSDDR
Protein: Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Skinny hedgehog protein) (Q8BMT9)
Organism: Mus musculus (Mouse)
Function: Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling during limb development. It also catalyzes N-terminal palmitoylation of DHH (By similarity). Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs (By similarity). Plays a role in proper testis cord formation and the differentiation of Leydig cells.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15075292, ECO:0000269|PubMed:18081866}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5VTY9}; Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with SHH in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q5VTY9}.
Interaction partners:
- Beta-alanine-activating enzyme
- Partner and localizer of BRCA2
- Acyl carrier protein, mitochondrial
- Sonic hedgehog protein
- Desert hedgehog protein
Sequence:
MLPGWELTLCLLVSLGFHFRSFYEVYKVSREHEEELDQEFELEMDTLFGGLKKDPTDFEWNFWMEWGKRRLVWLFIGHMAVSQLATLLTKKHRPWIVMVYGMWACWCVLGAPGVVMVLLHSTIAFCVAQFRSVLLSWLCSLLLLSTLRLQSVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCRQPPSAQPTPSAQGASHSYPWLLTYVFYYPVFHNGPILNFPEFFRQMQQPELNSLQHSLCIVAKGLGRLLCWWWLAELMVHLMYMHALYSSAPLLESVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPPLPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPLGGSQHGLLGTLLSTATTFAFVSYWHGSYEDLWCWAALNWLGVTVESGVRRLLETPCVRETLARHLSPQAHHRLHALLAACSTSMLILFNLVFLGGIQVGKTYWNRIFLQGWPWVTLSVLGFLYCYSHVDIAWAQTYTVL
Protein: Protection of telomeres protein poz1 (Pot1-associated protein poz1) (O13852)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Telomeric DNA-binding protein that negatively regulates telomerase and telomere length.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:18535244}. Chromosome, telomere {ECO:0000269|PubMed:18535244}.
Interaction partners:
- Coiled-coil quantitatively-enriched protein 1
- Protection of telomeres protein tpz1
- DNA-binding protein rap1
- Telomere length regulator taz1
- Telomerase reverse transcriptase
- Protein ten1
- Protein stn1
- Protection of telomeres protein 1
- Trehalose-phosphatase
- Telomere elongation protein est1
Sequence:
MNEKIRSQSVLNTLETFFIKENHYDMQREESSIVNACLRYLGYSKSMCHEKMPIFMDIAFIEYCFNLSLDPSSFQNLPITQTQPDSQQILWEYSLISNALERLENIELERQNCMREDGLVKYTNELLLNKETLNNEALKLYSCAKAGICRWMAFHFLEQEPIDHINFTKFLQDWGSHNEKEMEALQRLSKHKIRKRLIYVSQHKKKMPWSKFNSVLSRYIQCTKLQLEVFCDYDFKQREIVKMLTSNIN
Protein: SD07783p (Q95TD6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPHRSRSLPTEIEVYKKEGNDFLENGKLVDAIDAYSAALAKYPQGEVLYLNRATALMRRGWFGDIYAALRDCHEALRLDPSYVKAHFRLARALLELHRPQDADQCLQALIQRFPDFANNHGVLMLNKDIKENRRQSKSPEAPELQPVEVDDGFRYLRLKNAEYDLRSTARDYMQRYVGHCNVTTDIKEANYLGSQGEFIAAGSDDGNMYIWEGDTGKIRAVYRADSAIVNCVQPHPSICMLATSGIDHNIKIWSPCAASAEERPNLVADVTRFVEDNQEKMRLDPFELHTRNAYCFNN
Protein: Inner membrane symporter YicJ (P31435)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Alpha-xylosidase
- Uncharacterized inner membrane transporter YicL
Sequence:
MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFNILAVCVRGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSATISIIIALFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQGKRRCQQQFTSQEVQN
Protein: Cleavage stimulation factor subunit 2 (A0A8J8XR33)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAGLPVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGESISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLISGNPQPVHVAGPGSGPNVSMNQQNPQAPQAQSLSGMHVNGAPPMMQASMPGGVPAPVQMAAAVAGPGPGSLAPAGVMQAQVGMQGAGPVPMERGQGTLQHSPVGPAGPASIERVQGQRTWMIWASVRGSTPSLLVSGGLDGIAVLPMQDPRAAMQRGALPANVPTPRGLLGDAPNDPRGGTLMTVTGEVEPRAYLGPPPPPHQGPPMHHVPGHEGRGPPPHDMRGGPLAEPRPLMAEPRGPMLDQRGPPLDARGGRDPRGLDARGMEARAMEARGLEARAMEARAMEARAMEARAMEARAMEARAMEARGMDTRGPVPGPRGPIPSGIQGPNPMNMGAVVPQGSRQVPVMQGAGMQGASMQGGSQPGGFSPGQSQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP
Protein: Thioredoxin reductase 1, mitochondrial (EC 1.8.1.9) (P91938)
Organism: Drosophila melanogaster (Fruit fly)
Function: Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.
Subcellular location: [Isoform B]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform A]: Cytoplasm.
Interaction partners:
- Thioredoxin-2
- cystathionine gamma-lyase
- Thioredoxin reductase 2, mitochondrial
- FI04487p
- Inactive selenide, water dikinase-like protein
- Selenide, water dikinase 2
- dihydrolipoyllysine-residue acetyltransferase
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Sequence:
MNLCNSRFSVTFVRQCSTILTSPSAGIIQNRGSLTTKVPHWISSSLSCAHHTFQRTMNLTGQRGSRDSTGATGGNAPAGSGAGAPPPFQHPHCDRAAMYAQPVRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGSFVDSHTLLAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITKRSGLDPTPASCCS