wanglab/gogpt-training-data huggingface dataset:
Protein: Leucine-rich repeat protein (LRRP) (Q4GZB5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSRFAASGDGKVVARKERALMSVKNFIELIPLDIDLETTRQLVLKGKNITAIPPNIGTLLREVRRLDLSTNDVRDITPLATLANLTSINLTRNPHLLSIAPLASLHLTVVVVAHCGLRSLVGLEGSAGTLKTLVVNDNNLLLRSPSGKCVEGAGADEIATAVKNYDVIADLTECETLVLSRNPLLCSLYAGPTEEDKTHPQKKAEAGEETKCEPDWEHPLSAIVKMTCLKKLSLSGCGLTSLPRHWFIPKVTELRLSQNKLKSLVPEGVLFRSVKILDVSHNELKEASTLRRCRFVYHLGVRGNPFVEDGNVSTGAKRKAGKGDDDNKSESPPPAKKNLGVVLQYLMRIMPHLEMVDGTPLAQLLPTEQDDERKETVEFTANKQEESAESVADDGGSKVPEEEDNALEPPETSELGKPAIVRRGQTNLLATKKRRLSAEGAAVTQILLKRKTEASGW
Protein: Penta-EF hand domain-containing protein 1 (Apoptosis-linked gene 2 protein homolog A) (Dd-ALG-2a) (DdPEF-1) (Q95YL5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11481037, ECO:0000269|PubMed:11927596}. Membrane {ECO:0000269|PubMed:11481037, ECO:0000269|PubMed:11927596}; Peripheral membrane protein. Note=Membrane-associated in the presence of Ca(2+). {ECO:0000269|PubMed:11481037}.
Interaction partners:
- ESCRT-I complex subunit tsg101
- Putative calpain-like cysteine protease A
Sequence:
MMSYGYQQTPIVAPPAKFQALWFYSFYTQIQHQQLHEMSAWFRSIDKDRSGSISAMELQHLHVGYGPLGIETATKLIRVFDVDKSGQIDFYEYAALHQFINILYANFLANDRNRSGTIDAQEIHRALGTSGFNLPFNTVNLLFLKASPRGYGLKFSDFLGLCASIAIARSLFEAHDRMRTGVAHLNVNHIYDIISLV
Protein: Transcriptional activator HAP2 (A0A1D8PE35)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367155}.
Interaction partners:
- Hap5p
- Hap3p
- Hap43p
- Hap31p
- Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein
- DNA polymerase epsilon noncatalytic subunit
- Suppressor of ferric uptake 1
Sequence:
MTSLEDPNGQAQATYFQESVSTTGNSTPTVTQSNDPQHHHHHQQQQQQHHHHHVGSYYQDSPSSTYTYEVEGDYLENHPNVTSTSAEQGTGTMPTYVDNDNIHGGVGVGMGVETEEEDDDDTNGASIGNGSGSGGGSGGGEQPFYVNAKQYHRILKRRIARAKLEENLKIARTRKPYLHESRHKHAMRRPRGQGGRFLTAAEIAELEKAKQQQQQQQQQQQQQNEQSNQENNNENGNEIKKENQHVDDNNEIKNGDNNINKENIIENNKEEIDPNNVIIKKENNNNEVNHEMNNIENEQSSNEDFNQNNNNNINNNNTTISNNDNENGNTISSSKSNELQESIKNDNNNNNNNNGNDLQEEEER
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F4JTL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGLALFSSDGKLIWKGSTQTGKRRPQEEATMKHSGGNQACYVLGQKTPSIRDLYSLGHKLGQGQFGTTYMCKEISTGREYACKSITKRKLISKEDVEDVRREIQIMHHLAGYKNIVTIKGAYEDPLYVHIVMELCSGGELFDRIIQRGHYSERKAAELIKIIVGVVEACHSLGVMHRDLKPENFLLVNKDDDFSLKAIDFGLSVFFKPGQIFEDVVGSPYYVAPEVLLKHYGPEADVWTAGVILYILVSGVPPFWAETQQGIFDAVLKGHIDFDSDPWPLISDSAKNLIRGMLCSRPSERLTAHQVLRHPWICENGVAPDRALDPAVLSRLKQFSAMNKLKQMALRVIAESLSEEEIAGLKEMFKAMDTDNSGAITFDELKAGLRRYGSTLKDTEIRDLMEAADIDKSGTIDYGEFIAATIHLNKLEREEHLLSAFRYFDKDGSGYITIDELQHACAEQGMSDVFLEDVIKEVDQDNDGRIDYGEFVAMMQKGIVGRTMRKSINMSIRNNAVSQ
Protein: Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) (P69503)
Organism: Escherichia coli (strain K12)
Function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Subcellular location: Cytoplasm.
Interaction partners:
- Adenine deaminase
- GMP synthase
- Xanthine-guanine phosphoribosyltransferase
- Hypoxanthine phosphoribosyltransferase
- Purine nucleoside phosphorylase DeoD-type
- GMP reductase
- Adenylosuccinate lyase
- Bifunctional purine biosynthesis protein PurH
- Adenylate kinase
- Guanylate kinase
Sequence:
MTATAQQLEYLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIDLLVERYKNAGITKVVGTEARGFLFGAPVALGLGVGFVPVRKPGKLPRETISETYDLEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVADAAFIINLFDLGGEQRLEKQGITSYSLVPFPGH
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (A0A0B4KFY0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Aurora kinase
- Aurora kinase B
Sequence:
MWCIVNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRNRLSGDSGSSGSGIQLMLALRVKFWVPVHFILQESVRNLFYMQARRDLLEGRLTAPDWSGAAKLAALLCQADGLRFNESSLKADCPMRMRRELAQQQQQQQQQAQQHRLEQQRKEKEHVLSFKKRRLSKQKSMEHIEVCTLPAASTTSCSLQPSPSASASASASASASASASTSACSQTHSNSSSSSPSNSSSQTGLDERLASNPLRVYEEYFMQPSCEGEPPADYLRQIAVEHGKLAKLQMSLKTAKYWLLKSIQDLEGYGEELFSGVTTNESATRCDIAVGAHGITVCRGGEKQSIPFGAIAAAKSLRRTFKLEYVDDHNDRKELEIKLPKQPIAAGLYRSITERHAFYVCDKVRGVVTNQFTRDLKGTIASMFMENTELGKRYVFDIQHTCREVHDQARRTLHERGGDLVAEGAEGCSAVAGGLGASAVGEPGVSPWAMALTTGAGGSMAGKIDLAIREKEAREAAIERCVDTRISEAMQCKICMDRAINTVFNPCCHVIACAQCAARCSNCPNCRVKITSVVKIYLPPELRTSQTGSGATTTSSSSIMGDGQVEEQLLQQQLDEISAAPASLEAGADAGVGVGGMAVGAGAGAGATGPGGQPKVTTAAXNWLCSLLFRLMEWVCVPIV
Protein: Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (Lemur tyrosine kinase 1) (Q80YE4)
Organism: Mus musculus (Mouse)
Function: May be involved in neuronal differentiation.
Subcellular location: Membrane {ECO:0000269|PubMed:17651901}; Single-pass type I membrane protein {ECO:0000269|PubMed:17651901}. Cytoplasm {ECO:0000269|PubMed:17651901}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:17651901}. Cell projection, axon {ECO:0000269|PubMed:17651901}. Cell projection, growth cone {ECO:0000269|PubMed:17651901}. Note=Predominantly perinuclear. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane. Note=Peripheral membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MSSSFFNPSFAFSSHFDPDGAPLSELSWSSSLAVVAVSFSGIFTVVILMLACLCCKKGGIGFKEFENAEGDEYVADFSEQGSPAAAAQTGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDLGRHSLLYLKEIGHGWFGKVFLGEVHSGVSGTQVVVKELKVSASVQEQMQFLEEAQPYRALQHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVTESMAPDPLTLQRMACEVACGVLHLHRHNYVHSDLALRNCLLTADLTVKVGDYGLSHCKYREDYLVTADQLWVPLRWIAPELVDEVHGNLLVVDQTKSSNVWSLGVTIWELFELGAQPYPQHSDRQVLAYAVREQQLKLPKPQLQLALSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGTTELEEEFERRWRSLRPGGSTGLGSGSAAPAAATAASAELTAASSFPLLERFTSDGFHVDSDDVLTVTETSHGLNFEYKWEAGCGAEEYPPSGAASSPGSAARLQELCAPDSSPPGVVPVLSAHSPSVGSEYFIRLEGAVPAAGHDPDCAGCAPSPQAVTDQDNNSEESTVASLAMEPLLGHAPPTEGLWGPCDHHSHRRQGSPCPSRSPSPGTPMLPAEDIDWGVATFCPPFFDDPLGASPSGSPGAQPSPSDEEPEEGKVGLAAQCGHWSSNMSANNNSASRDPESWDPGYVSSFTDSYRDDCSSLEQTPRASPEVGHLLSQEDPRDFLPGLVAVSPGQEPSRPFNLLPLCPAKGLAPAACLITSPWTEGAVGGAENPIVEPKLAQEAEGSAEPQLPLPSVPSPSCEGASLPSEEASAPDILPASPTPAAGSWVTVPEPAPTLESSGSSLGQEAPSSEDEDTTEATSGVFTDLSSDGPHTEKSGIVPALRSLQKQVGTPDSLDSLDIPSSASDGGCEVLSPSAAGPPGGQPRAVDSGYDTENYESPEFVLKEAHESSEPEAFGEPASEGESPGPDPLLSVSLGGLSKKSPYRDSAYFSDLDAESEPTFGPEKHSGIQDSQKEQDLRSPPSPGHQSVQAFPRSAVSSEVLSPPQQSEEPLPEVPRPEPLGAQGPVGVQPVPGPSHSKCFPLTSVPLISEGSGTEPQGPSGQLSGRAQQGQMGNPSTPRSPLCLALPGHPGALEGRPEEDEDTEDSEESDEELRCYSVQEPSEDSEEEPPAVPVVVAESQSARNLRSLLKMPSLLSEAFCDDLERKKKAVSFFDDVTVYLFDQESPTRETGEPFPSTKESLPTFLEGGPSSPSATGLPLRAGHSPDSSAPEPGSRFEWDGDFPLVPGKAALVTELDPADPVLAAPPTPAAPFSRFTVSPTPASRFSITHISDSDAQSVGGPAAGAGGRYTEA
Protein: Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) (A6NC98)
Organism: Homo sapiens (Human)
Function: Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC. Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q4QRL3}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:25762780}. Endoplasmic reticulum {ECO:0000269|PubMed:21289099}. Golgi apparatus {ECO:0000269|PubMed:21289099}. Cytoplasm {ECO:0000269|PubMed:21289099}.
Interaction partners:
- Protein Hook homolog 1
Sequence:
MEGGKGPRLRDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGALLLRVLGIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGDRLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRPRREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGSPSPAPMRRAQSSLCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQRFRQRHPGPLGAPVSHSKGPGVGWENSAETLQEHETDANREGPEVQEPEKRPLTPSLSQ
Protein: IP12580p1 (Q9VIG3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LP04053p
- Uncharacterized protein, isoform A
- GH09761p
Sequence:
MATALELSPTEIRGLCQRYFHQDVSNSDTGFDIVNYTLKPTSDAPAGYLGSHLYLHVTLKLHNSEEVRQLTFFSKSAPVGNESRMEYLEDFGVFEKEIAVYQNVLPDLHKACAEVAPKCYYADKNLLIFENLADQGYRMGAGRDGLLTYEQLHCCLKTLAAMHAGSIIQEQRTGQKIAQSQPKSVVENAYPSDVSPEHMRMVNFQNACLVLKEFIKLIPKYQSKLDYVLENFTEKMSFIFEAVKTSDVYQNTILHGDLWANNIMFQYGRYGEVPLQCRLVDFQLARYAPPVLDVLTVLTIPTSKEFRDAHLSELLAEYYRFMTEFLKRADLDIARFIPEQTFYESVQKFRSVGLIESCLFCHLVILPPHCTQKLTSSVDGFNDFFTNKRIEICLEAFNTDELYRSRLVDMIEDFVDQFVINV
Protein: Sphingolipid C4-hydroxylase sur2 (EC 1.-.-.-) (Syringomycin response protein 2) (O94298)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Dihydrosphingosine 1-phosphate phosphatase C823.11
- Sphingoid long chain base kinase 4
- PIGF/3-ketodihydrosphingosine reductase fusion protein
- Sphingosine N-acyltransferase lag1
- Sphingosine N-acyltransferase lac1
- Sphingolipid delta
- Ceramide very long chain fatty acid hydroxylase scs7
- Probable acyl-CoA desaturase
Sequence:
MVTTVEMLTTWNPVTVSLVSPVIIYWVASAFFGFLHYIELPVFEKYRIHPPEEIARRNRVPQMAVVKAVLFQQLCEVVVGIALAMFEGYPEPIDEAKQMLRYEAFFSKNLPALLQVAPFAPKLAYNFIVPAFQYFFAFFIIDSWQYFWHRYLHYNKKLYNMIHAHHHRLQVPYAMGALYNHPFEGLILDTFGAGVAYLAAGLSPQQAVIFFTLSTLKTVDDHCGYVFPYDPLQMFFANNARYHDLHHQPYGFQKNFSQPFFTFWDHVLGTYMPPKSETPYEKKQKAKNAKKVN
Protein: Glutathione S transferase E2 (EC 2.5.1.18) (RE69679p) (Q7JYZ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- Glutathione S transferase O1
- Glutathione S transferase T2
- GH16740p
- Glutathione S transferase T1
- glutathione transferase
- Inactive glutathione S-transferase D3
- Glutathione S-transferase S1
- Glutathione S transferase D11, isoform B
- Glutathione S transferase D10, isoform A
Sequence:
MSDKLVLYGMDISPPVRACKLTLRALNLDYEYKEMDLLAGDHFKDAFLKKNPQHTVPLLEDNGALIWDSHAIVCYLVDKYANSDELYPRDLVLRAQVDQRLFFDASILFMSLRNVSIPYFLRQVSLVPKEKVDNIKDAYGHLENFLGDNPYLTGSQLTIADLCCGATASSLAAVLDLDELKYPKVAAWFERLSKLPHYEEDNLRGLKKYINLLKPVLNLEQ
Protein: High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor) (Ecotropic retrovirus receptor) (EcoR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) (P30823)
Organism: Rattus norvegicus (Rat)
Function: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q09143}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Neutral amino acid transporter B
- Amino acid transporter
- Peroxisome proliferator-activated receptor gamma coactivator 1-beta
- Nuclear receptor interacting protein 1
- Steroid hormone receptor ERR1
- Amino acid transporter heavy chain SLC3A2
- Solute carrier family 1, member 4.
- Steroid hormone receptor ERR2
Sequence:
MGCKNLLSLGQQMLRRKVVDCSREESRLSRCLNTYDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGKPIGEFSRQHMALNAPGVLAQTPDIFAVIIIIILTGLLTLGVKESAMVNKIFTCINVLVLCFIMVSGFVKGSIENWQLTENKSSPLCGNNDTNVKYGEGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDTDSPLPGAFKYRGWEEAKYAVAVGSLCALSTSPLGSMFPMPRVIYAMAEDGLLFKFLAKINDRTKTPIIATVTSGAIAAVMAFLFELKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMARTTDELDQVDQNEMVSASESQTGFLPAAEKFSLKTILSPKNMEPSKFSGLIVNISAGLLAVLIITVCIVAVLGREALAEGTLWAVFVMTGSVLLCMLVTGIIWRQPESKTKLSFKVPFVPVLPVLSIFVNIYLMMQLDQGTWVRFAVWMLIAFAIYFGYGVWHSEEASLAAGQAKTPDSNLDQCK
Protein: DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPC40) (P52432)
Organism: Mus musculus (Mouse)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O15160}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O15160}.
Interaction partners:
- DNA-directed RNA polymerase I subunit RPA43
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase III subunit RPC10
- DNA-directed RNA polymerase I subunit RPA34
- DNA-directed RNA polymerase I subunit RPA49
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase I subunit RPA2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I and III subunit RPAC2
Sequence:
MAAAQAVEEMRTRVVLGEFGVRNVHTTDFPGNYAGYDDAWDQNRFEKNFRVDVVQMDEDTLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPILADPRLFEYRNQGEEEGTEIDTLQFRLQVRCTRNPNAAKDSSDPNELYVNHKVYTRHMTWVPLGNQADVFPEGTIRPVHDDILIAQLRPGQEIDLMMHCVKGIGKDHAKFSPVATASYRLLPAITLLEPVEGEAAEELSQCFSPGVIEVEEVQGKKVARVANARLDTFSREIFRHEKLKKAVRLARVRDHYIFSVESTGVLPPDVLVSEAIKILMGKCRRFLDELDAVEMD
Protein: Deubiquitinase and deneddylase Dub1 (ChlaDub1) (EC 3.4.22.-) (B0B9A0)
Organism: Chlamydia trachomatis serovar L2 (strain ATCC VR-902B / DSM 19102 / 434/Bu)
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease possesses deubiquitinating and deneddylating activities (By similarity). Impairs ubiquitination and degradation of NF-kappa-B inhibitor alpha (NFKBIA), thereby preventing NF-kappa-B activation.
Subcellular location: Secreted {ECO:0000269|PubMed:18503636}. Host cell {ECO:0000269|PubMed:18503636}. Membrane {ECO:0000269|PubMed:18503636}; Single-pass membrane protein {ECO:0000269|PubMed:18503636}. Note=Secreted, and delivered into the host cell. Located predominantly on the plasma membrane and to a lesser extent on intracellular membranes, especially the host cell nuclear envelope.
Interaction partners:
Sequence:
MLSPTNSTSKTAPVPPRDSSKPVLISEEPRNQLLQKVARTALAVLLVVVTLGLILLFYSFSDLQSFPWCCQTHPSTKEQPTISIPVPLPSPPLAVPRPSTPPPPVISRPSTPSAPKPSTPPPLLPKAPKPVKTQEDLLPLVPEQVFVEMYEDMARRQTIEALVPAWDSDIIFKCLCYFHTLYPGLIPLETFPPATIFNFKQKIISILEDKKAVLRGEPIKGPLPICCSKENYRRHLQRTTLLPVFMWYHPTPKTLSDTMQTMKQLAIKGSVGASHWLLVIVDIQARRLVYFDSLYNYVMPPENMKKELQSFAQQLDQVYPAYDSKKFSVKIAAKEVIQRGSGSSCGAWCCQFLHWYLKDPLTDALNDLPVDSVERHENLASFVQACEAAVQDLPELSWPEA
Protein: dual-specificity kinase (EC 2.7.12.1) (A9JRD5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MILSRKPDGPVTAARHGDGLYDSYMRTDHIVNQDADVNGQSPSGLPPLPKHTGVIKPTMKDHQAIRGGQMKVKYVYEDSYNRKLNGVSQHNGTSQVPAKPPPAISKERSVDSNSSVKSSESSTKVTKLGSPMTPEQALKQHRQQMTTLEQQEIHNYSEIYFLGPNAKKRQAVAGGTNNSGYDDDQGGYIHVPHDHLAYRYEFLKVIGKGSFGQVAKVYDHKLQQHVALKIVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALHRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKNFISSKGHPRYCTVSTLSNGTIVLNGSRSRRGKMRGAPGSKEWGTALKGCEDATFIDFLKKCLDWDPSTRMTPVQALRHPWLYKRLPKPAPGGEKTVLPKRISEHSTSFPTIISKVPPVMGSTNNKLRTTMMGDSTGSIPFRTVLPKLVS
Protein: Probable G-protein coupled receptor 27 (Super conserved receptor expressed in brain 1) (Q9NS67)
Organism: Homo sapiens (Human)
Function: Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPRTTQATHPCDLKGIGL
Protein: Palmitoyltransferase ZDHHC3-A (EC 2.3.1.225) (Acyltransferase ZDHHC3A) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 3) (F1RE57)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and regulates their association with membranes (Probable). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8R173}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MRSPVPRFRDVERQASGLQPPQCLPSCHERQSSMWFIKDACGIVCAIITWFLVFFAEFVVLFVMLIPSKNLTYSLVNGTLFNSLAFLALASHFRAMCTDPGAVPKGNATKEYIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMYICLISLHSLVMVVFHFLNCFEDDWTKCSTFSPPATVILLILLCFEGLLFLIFTSVMFGTQVHSICTDETGIEKLKREDPTWEKTQCWEGMKSAFGGPLSVTWFSPFTDLSCQKDDSSPVPMFPQGEIIEEDVIEIPLEPH
Protein: Citrate synthase, peroxisomal (EC 2.3.3.16) (Q8MQU6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Peroxisomal protein involved in the cellular biosynthesis of citrate, and required primarily for cell growth and modulation of multicellular development.
Subcellular location: Peroxisome {ECO:0000269|PubMed:15225305}.
Interaction partners:
- malate synthase
- Probable aconitate hydratase, mitochondrial
- Probable cytoplasmic aconitate hydratase
- Probable ATP-citrate synthase
- Probable malate dehydrogenase 2, mitochondrial
- Probable malate dehydrogenase 1
- Probable malate dehydrogenase 3
- ATP citrate synthase
- isocitrate lyase
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Sequence:
MAHIDRINILANHLSKEEEEENELLTSPVSADKKKETVTVTDNRNGKSYDFKIKNDTINALNFKELQLAKGDGGLMIYDPGFQNTAVVTSYITYIDGDKGILRYRGYPIEELAERSNFLEVAYLLINGNLPNKSQLDGWSNKIMTHTFLHENLVGLMKTFRYDAHPMGMLISTVAALGTFYPEANPALAGGDIFKSENVRNKQIYRIVGKLPTIAACAWRHRIGRPYNTPVNHLGYTENFLYMLDKLSEPDYKPNPVLCRALEILFILHADHELNCSTAAMRHISSSGTDPYTSVAGAAGALYGPSHGGANEAVLDMLIHIGSKENIPQFISDVKSKKKKLMGFGHRIYKNYDPRAKIIRRVAYEVFESLGKEPLIEVATELEKQALEDEYFVSRKLYPNVDFYSGLIYKAMGFPTDMFPVLFTIPRAVGWLAHWVEHLEDPETKIYRPRQVYKGEWFRNYVPIDGRPPAKVRSQDSYSSATTKRYSKVTSH
Protein: Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) (P58774)
Organism: Mus musculus (Mouse)
Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P58775}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P58775}.
Interaction partners:
- Tropomyosin alpha-1 chain
- Troponin I, cardiac muscle
- Actin, alpha cardiac muscle 1
- Troponin T, fast skeletal muscle
- Troponin I, fast skeletal muscle
- Troponin T, slow skeletal muscle
- Actin, alpha skeletal muscle
- Troponin C, skeletal muscle
- Myosin-11
- Myosin light chain 1/3, skeletal muscle isoform
Sequence:
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
Protein: DNA-directed primase/polymerase protein (EC 2.7.7.102) (Q57Z42)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLWCRATFTEHFDSEKCRLFPTQQQLFDFIDSRNNGEDKLDIEGGQRWLPFSVEFPSEEEAVHILASRSIRSAPSSSASAAGRLFRKRSSDGDVKMEYSNAGRPKLALREDYSILYGETPLSGQSRMFLAATVEGLAQIVEDIEPLQQHLYEVIREKAACHMYLDVERERDYSAWRPVVHVVDSDSDSSCGDNDSNKCVADVYECESTTYASALETALWRPPRCCPWNCRIRADNSKTTTLLLRELYTFLREVYPELLSGLKQDHLQLKRDVSGCPTTPSEHDTFFEEWPLGLGVSVLVMRSVQQHQYDGKGSAKFSQHYVVKFDGHWFGSNGDVGRLVSQFIDYLYERVESDVQLHTALFYHDVPKHFPVLPSEDAPNLPFLPLRCVIDSAVYSRNRTMRCLGSCKLHKTSILALEKTTERMTDAVSLFFASLITLPHGTQRVVTVPDVSPPRSVSGTPNASTKGGNLLSKQLPLEEAERYSALAKYIGEQWSSAGGVECGVSSIRRCGDRYLLFMLKGSRYCGNIGRQHRSNNVYISVDLHCGMWVQKCFDPECAGYRGPPQPLPPLVGNQCCGAPNVVEGTGGNRAVSLASHASMRTPFRPSQDA
Protein: Putative peroxisome targeting signal 1 receptor (E9AEW5)
Organism: Leishmania major
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
- Peroxisomal membrane protein PEX14
- propanoyl-CoA C-acyltransferase
- Peroxin-7
- Putative sterol carrier protein
- Peroxin-13
- Peroxin-12
- RING-type E3 ubiquitin transferase
- 2-aminoethylphosphonate:pyruvateaminotransferas e-like protein
- Peroxisomal ATPase PEX6
- non-specific serine/threonine protein kinase
Sequence:
MDCNTGMQLGQQFSKDVTMMHGGVPMSGAMSEQDALMVSAQVGGASPMMAAQWAQNFQQQQAMQAMRQQHEMEQAFQNSQQQQHAAVAQSGQMLGMAGPQQQQFMVQQQQQASMMNAAMMSQGMMTANMGFGMMMPRTQYQPLPNLSVLQPNQQQQQQQQLVNLAPAVQDSAWADQLSQQQWSTDYSQVQTFSAPGMEDKTVEERIKDSEFYKFMDQVKNKEVLIDEEKGELVQGPGPEVGVPEDAEYLRHWAEMEGLNMPEGVFQPPPPASAMMTPENGDPDTYIKEMDMAENDVEDWAQEYAEMQERLQKVTNNTDYPFEPNNPYMFHDFPFDEGMEMLQLGNLAEAALAFEAVCHKDSSNEKAWQILGTTQAENEKDGLAIIALNNARKLNIRNLEVHAALSVSHTNERNADAAMDSLKAWLVNHPEYEQLASVSIPPDAELDVQETFFFADPSRMREARTLYEAAIEMNPSDSQLFTNLGVLHNVAHEFDEAAECFRKAVALHPDDPKMWNKLGATLANGGHPDQALEAYNRALDINPGYVRAMYNMAVAYSNMSQYNMAARQIVKAIASQQGGTKPSGEGSIMATRNMWDLLRMTLNLMDRDDLVQLTYNEQLEPFVKEFGLEGHV