wanglab/gogpt-training-data huggingface dataset:
Protein: Succinate--CoA ligase [ADP-forming] subunit alpha-1, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha-1) (SCS-alpha-1) (Q8GTQ9)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03222, ECO:0000269|PubMed:16270230}.
Interaction partners:
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- dihydrolipoyllysine-residue succinyltransferase
- ATP citrate synthase
- 4Fe-4S ferredoxin-type domain-containing protein
- ATP citrate synthase
- ATP citrate synthase
- ATP citrate synthase
Sequence:
MARQATKLIANLSKKLSSSNPHTRCSEQTVWIGAAPPAVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVEEAKAETKANASVIYVPPPFAAAAIMEGLEAELDLIVCITEGIPQHDMVRVKAALKKQSRTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGTLTYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFIADPQTEGIVLIGEIGGTAEEDAAALIKESGTQKPVVAFIAGLTAPPGRRMGHAGAIVSGGKGTAQDKIKALKEAGVTVCESPAKIGVSMLEVFKQRGLV
Protein: Inwardly rectifying K+ channel protein (Q8WQ82)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
Interaction partners:
Sequence:
MRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEIYKIQEGFRTPASPSTQSRCSCSSGYQTPGRQSRLRWQLSVPL
Protein: Small ribosomal subunit protein eS26 (40S ribosomal protein S26) (O45499)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62854}. Cytoplasm {ECO:0000250|UniProtKB:P62854}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:P49171}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P49171, ECO:0000250|UniProtKB:P62854}.
Interaction partners:
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL6
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein eS19
Sequence:
MTFKRRNHGRNKKNRGHVAFIRCTNCGRCCPKDKAIKKFVVRNIVEAAAVRDIGDASAYTQYALPKLYHKLHYCIACAIHSKVVRNRSREARRDRNPPPRFGQRAAAARPGAPGPRP
Protein: Nephrocystin 7.2 (Zinc finger protein GLIS2b) (T1WQU8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLSLDEPLDLKVPRGWISGRDRGARSPPTLSSSPIHGKGAGQLRMADDGTAVIVPASPASPHTGVLRSNSETPTPPAVDLSLSPSSRNTACSPELSNGSGSAPVFPGDSAHIRYVEGGATSQAFQFFVPIGAGGGLHLPSSMFIRQPKDTRASPDLSADEQLACRWRKCHLLFDSLQDLVDHVNDFHVKPEKDSGYCCHWEGCARKGRGFNARYKMLIHIRTHTNEKPHRCPTCNKSFSRLENLKIHNRSHTGEKPYICPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMVGCLKRYTDPSSLRKHIKAHGHFVAQEQGGGVGSLIKQSQIAGVGKDSELTYVSGAHIIIPSAAAALLGGHALQGLGGSLPLSPLSPRPLDLSTLGCPNSPTAGLGGTPILSFSSSPLGLTKSPLLSPSFSSSTLGLPMLPILGSERRDHGKGKIRGEEGEDEIHGGVLNLSTGASHDPLSWVVIPSGPVVLKPAVVN
Protein: Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (eIF1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C) (Q8BMJ3)
Organism: Mus musculus (Mouse)
Function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Eukaryotic translation initiation factor 1
- Eukaryotic translation initiation factor 1b
- Eukaryotic translation initiation factor 1A
- Eukaryotic translation initiation factor 4C
- Eukaryotic translation initiation factor 4C
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 2 subunit 2
- Ubiquitin-like protein FUBI
- Eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 3 subunit I
Sequence:
MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI
Protein: Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Q90462)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU368113}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368113}; Cytoplasmic side {ECO:0000256|RuleBase:RU368113}. Cell projection, growth cone membrane {ECO:0000256|ARBA:ARBA00004503, ECO:0000256|RuleBase:RU368113}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004503, ECO:0000256|RuleBase:RU368113}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004503, ECO:0000256|RuleBase:RU368113}. Synapse {ECO:0000256|ARBA:ARBA00034103, ECO:0000256|RuleBase:RU368113}. Cell projection, filopodium membrane {ECO:0000256|RuleBase:RU368113}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368113}.
Interaction partners:
Sequence:
MLCCIRRTKPVEKNEEADQEIKQDGIKPEENAHKAATKIQASFRGHITRKKMKDGEKEEENGEVPEEQEEEKPADASTETQEDPKPEQPNSPANEAPPTAAADPAPSDTPAKEEVKEPQQEVEKPKEEEQSSAAADEKPEEEGNAQKEEKEEEKPADVPEAESQETHQIDKPDAAEESKPAEGAVSDAGTEESV
Protein: Probable aminotransferase TAT2 (EC 2.6.1.-) (Tyrosine aminotransferase 2) (Q9FN30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 4-hydroxyphenylpyruvate dioxygenase
- Arogenate dehydrogenase 1, chloroplastic
- Homocysteine S-methyltransferase 1
- Homocysteine S-methyltransferase 3
- Tyrosine decarboxylase 2
- Homocysteine S-methyltransferase 2
- Arogenate dehydrogenase 2, chloroplastic
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 3, chloroplastic
- Methionine gamma-lyase
- Phenylalanine ammonia-lyase 4
Sequence:
MENGATTTSTITIKGILSLLMESITTEEDEGGKRVISLGMGDPTLYSCFRTTQVSLQAVSDSLLSNKFHGYSPTVGLPQARRAIAEYLSRDLPYKLSQDDVFITSGCTQAIDVALSMLARPRANILLPRPGFPIYELCAKFRHLEVRYVDLLPENGWEIDLDAVEALADENTVALVVINPGNPCGNVYSYQHLMKIAESAKKLGFLVIADEVYGHLAFGSKPFVPMGVFGSIVPVLTLGSLSKRWIVPGWRLGWFVTTDPSGSFKDPKIIERFKKYFDILGGPATFIQAAVPTILEQTDESFFKKTLNSLKNSSDICCDWIKEIPCIDSSHRPEGSMAMMVKLNLSLLEDVSDDIDFCFKLAREESVILLPGTAVGLKNWLRITFAADATSIEEAFKRIKCFYLRHAKTQYPTI
Protein: Myelin proteolipid protein (PLP) (Lipophilin) (P60202)
Organism: Mus musculus (Mouse)
Function: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17634366}; Multi-pass membrane protein {ECO:0000269|PubMed:17634366}. Myelin membrane {ECO:0000269|PubMed:17634366}. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.
Interaction partners:
- Proteolipid protein 2
- Myelin basic protein
- Myelin-oligodendrocyte glycoprotein
- Myelin-associated glycoprotein
- Myelin-associated oligodendrocyte basic protein
- 2',3'-cyclic-nucleotide 3'-phosphodiesterase
- Integrin alpha-V
- Myelin regulatory factor
- Transcription factor SOX-10
- Peripheral myelin protein 22
Sequence:
MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF
Protein: Cysteine synthase 1 (CS 1) (EC 2.5.1.-) (EC 2.5.1.47) (O-acetylserine (thiol)-lyase 1) (OAS-TL 1) (O-acetylserine sulfhydrylase 1) (O-succinylserine sulfhydrylase) (P50867)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway (By similarity). Can also use O-acetyl-L-serine.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P53206}.
Interaction partners:
- Homocysteine synthase
- Cystathionine beta-lyase
- Sulfite reductase subunit beta
- cystathionine gamma-synthase
- cystathionine gamma-lyase
- Multifunctional tryptophan biosynthesis protein
- assimilatory sulfite reductase
- 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
- phosphoserine transaminase
- Cysteine synthase 2
Sequence:
MFRQSVRRFATAALRSAAESPYNVRVSQAQGFVNGLTEAIGNTPLIRLKRLSEETGSNILAKAEFQNPGGSVKDRAALYVVKDAEERGLLKPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPENYNHKARRHAESLDNAVWTNQFDNTANRRAHIETTGPEIWAQTGGKLDAFTCSTGTGGTLAGITYYLKQASGGRVKSFLADPPGSVLHSYIQSGGKLVERSGSSITEGIGQGRITDNLQPDVGTLDGSLNISDEKTIEMIYRCLDEEGLYLGASSALNVVAAKEVAEKLGKGSTVVTILADGAYRYADRLFSKSWLESKGLRNAIPKHLEKYIVLP
Protein: 3beta,22alpha-dihydroxysteroid 3-dehydrogenase (EC 1.14.19.79) ((22R,23R)-22,23-dihydroxy-campest-4-en-3-one synthase) ((22S,24R)-22-hydroxy-5alpha-ergostan-3-one synthase) ((22S,24R)-22-hydroxyergost-4-en-3-one synthase) (3-dehydro-6-deoxoteasterone synthase) (Cytochrome P450 90A1) (AtCYP90A1) (Protein CONSTITUTIVE PHOTOMORPHOGENESIS AND DWARFISM) (Q42569)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes C3-oxidation steps in brassinosteroids biosynthesis. Converts (22S)-22-hydroxycampesterol (22-OHCR) to (22S,24R)-22-hydroxyergost-4-en-3-one (22-hydroxy-campesta-4-en-3-one, 22-OH-4-en-3-one), 6-deoxocathasterone (6-deoxoCT) to (22S,24R)-22-hydroxy-5alpha-ergostan-3-one (22-hydroxy-campesta-3-one, 22-OH-3-one), (22R,23R)-22,23-dihydroxycampesterol (22,23-diOHCR) to (22R,23R)-22,23-dihydroxy-campest-4-en-3-one (22,23-diOH-4-en-3-one), and 6-deoxoteasterone (6-deoxoTE) to 3-dehydro-6-deoxoteasterone (6-deoxo3DT, 6-deoxo-3-DHT).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Steroid 5-alpha-reductase DET2
- Steroid
- 3-epi-6-deoxocathasterone 23-monooxygenase CYP90C1
- 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1
- Cytochrome P450 86A1
- Peptidyl-prolyl cis-trans isomerase CYP71
- Delta
- Hydroxyproline-rich glycoprotein family protein
Sequence:
MAFTAFLLLLSSIAAGFLLLLRRTRYRRMGLPPGSLGLPLIGETFQLIGAYKTENPEPFIDERVARYGSVFMTHLFGEPTIFSADPETNRFVLQNEGKLFECSYPASICNLLGKHSLLLMKGSLHKRMHSLTMSFANSSIIKDHLMLDIDRLVRFNLDSWSSRVLLMEEAKKITFELTVKQLMSFDPGEWSESLRKEYLLVIEGFFSLPLPLFSTTYRKAIQARRKVAEALTVVVMKRREEEEEGAERKKDMLAALLAADDGFSDEEIVDFLVALLVAGYETTSTIMTLAVKFLTETPLALAQLKEEHEKIRAMKSDSYSLEWSDYKSMPFTQCVVNETLRVANIIGGVFRRAMTDVEIKGYKIPKGWKVFSSFRAVHLDPNHFKDARTFNPWRWQSNSVTTGPSNVFTPFGGGPRLCPGYELARVALSVFLHRLVTGFSWVPAEQDKLVFFPTTRTQKRYPIFVKRRDFAT
Protein: Large ribosomal subunit protein eL37 (60S ribosomal protein L37) (P61928)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P61927}.
Interaction partners:
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein eL20
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein uL13
Sequence:
MTKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSAKAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPKRAAVAASSSS
Protein: C2 domain-containing protein (Q580U6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGRATEAQRAEMAKEEKLQRALHENRQLKQEVLGLRDKLKILQVKFNKVTNDLKRVSPDMLKHLNEVASSAATSPPLSSMRTATSVGGAYATRQSTPGKRSFSLQPHAGTGEGAALSLGEAVDPAELQQCREALHRAQLEIVALRANTAATVGGTTAGPSPPSPAMVTVIEKLRQDLASAVVERDQRAAEVSVLRDELTRTRTQLEDVQFTQQQQLAVERHTCGMLNGRAQAAESGKQQLEAEFRRSVEILTRERDELALKLRLLQEEMDSEKRYGAGTVDPTQLVQVQADLQDKSRQITILTSRMQGSQQQVETLKNECSRLLDELQKFHAMHTETKRQLLELEGERNLLQVRCARVEELERTVKHKSEELIRTEQELLRTASTLQSCNRETEEAVRREFSSRLADVQGMRDSAEAQRREKERQLLEAQRELGELRRQLELTRENATMFQAQLEKSEEERQKLSAMASVAGYTVKEFGDEKVRRALAVVAMRGDSGIDRNGGTGGVTNGFSDKVPVNASDGAAGEALEMWDALRWDEGWEAQQLREALASAALDMELAESRCTQMNEQLERNRHLMQQLSHERDALLEENIEMRRRLTHVQTAFAKQQLESYNAAKTRGTTNGGKGSSDGIINFCIHDLECNDAMLRALGASQVAGAAVTLFFSLDGLRSYDTMMSPMFYSLDSPLDIRFCYDRLDRDEATVAEIRATTFVFQLHQVCGTGTNIVAMGELPGVALLQARESAVLERVKLVSGSGEEVGVVAVEMCALNLLLPILLDRPLSGVGKDGDFCLSSDAVRAALVAMRSVVALRVQVFRADGLQNSPTPQPYVFYTAAMPSTTHGGISCIRDTVVHTSTKALTSDPVFDEEPIDHRVVVDSELISFVSESSVVFVVFDAQARDVRSNLGVAEVPLRPLLASPQAVIRKTEVLHPQGTLSIGLSWVCRS
Protein: Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate aldolase) (P14843)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Interaction partners:
- Pentafunctional AROM polypeptide
- Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
- Chorismate synthase ARO2
- Chorismate mutase
- Aromatic/aminoadipate aminotransferase 1
- Probable prephenate dehydratase
- Aromatic amino acid aminotransferase 2
- Anthranilate synthase component 1
- Multifunctional tryptophan biosynthesis protein
- Transaminated amino acid decarboxylase
Sequence:
MFIKNDHAGDRKRLEDWRIKGYDPLTPPDLLQHEFPISAKGEENIIKARDSVCDILNGKDDRLVIVIGPCSLHDPKAAYDYADRLAKISEKLSKDLLIIMRAYLEKPRTTVGWKGLINDPDMNNSFQINKGLRISREMFIKLVEKLPIAGEMLDTISPQFLSDCFSLGAIGARTTESQLHRELASGLSFPIGFKNGTDGGLQVAIDAMRAAAHEHYFLSVTKPGVTAIVGTEGNKDTFLILRGGKNGTNFDKESVQNTKKQLEKAGLTDDSQKRIMIDCSHGNSNKDFKNQPKVAKCIYDQLTEGENSLCGVMIESNINEGRQDIPKEGGREGLKYGCSVTDACIGWESTEQVLELLAEGVRNRRKALKK
Protein: Myosin motor domain-containing protein (D3YT14)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAPVMHDGHGSTRSRDYRIMKRGEVPSQYSTIRNMPVPEHGKDVDQFLDAVFDQVLSKDEQRAAHFNSNQLANTIKGGKLRPEGYYEPPVQTYSPVPPRYPTLRRVDDSPLRSRAKSLPRIISPRHEHFVRRPHSRNSYSNESTSSDDQMNYRTRSRERSLPRFHSNNGYNYDPSQPVYMMPVQMNGHGEMILLSPVASEHKAQSRHRTHDRSHRHHVPSGVERYMAKRSPSVDILKPPMSRRTPDAMVEQTYVRPHLAQSPVGRQTSRFEEFSALPRGDSRARERMENPLLARQIPRAYPYQNGNVVPPPPSSYRAPSPAPTSGDRRGLNRLPQESYTEPAVKNTKNNSEYLSPHRFNLDEQKAVIRHEKETAKNAINMLSDRLRKLPPPVDNVRLIRPITPAQPPITQSPVPSEPVVVRTPSPVPQPTPPPPPPPVREEWVIRDSVERDPVTQGRIRGSFRKEPLVPQPPRPPVVAEKPAVKFVKAPWKLTIRKEMFYPGEVLNDIQIIDQVFAQIVEDCKKSYPYRIREQDRKQVETVLRQYEIPPSDLNNQSNIHPDVKVAVIELARLWPLYFNQVYEVVEKRPDESVSTIFAISEHGIRLIVHTPHDLENPLKIQDFFPFETIADVSLEANDILSVHVRHEDEENAYSAVRIKTNQAPQIKKTLDRCLSGGVVPKRKFVRALEDYVTSEVNHLSFKQGDVIELLQEPEGETPPVGNWLYGKIENRFGFLLAQYVDSTDGDNVPPIRHETSEDRDERVRFFDDEVPFSSERYTMIDFATKYFRKPKDKKKQETWAWEDISQIVRFSEKPISQSLLADLGNEESKYAVETFHAIMKFMGDEPLKKSESMTDVVFKVLLICHRQPTLRDEVYCQLIKQTTSNISQKPNSALRAWRLLTIITAYFPSSLTLKPYVLQYLGDNADEWQRPFHGTARICQTNMIQTFKYGGRKVLLNALEVQQITDGCQLRRQAFYISKDHNVSQTLRPITVAEEMIQELCNLLNVRSLHEQQEFSLCYTVGKDKHLNYCKNDNYLMDIITESEHKKLPFQFYLKRTVWVHPLRYDNAAYIDSMFDQVIDDYLRGSLISTNSLGQLTAATTEEIIKLAAYLFLLLPDNPKGLNAKTLPQIVPKSVIEPKHRHQEEMVTRISRQLKMFGGRMRPAEAKSHFLELLSTWPTFGVLHYRLKSVVENGHQLPEVILTINKSGIQLLQPKSKEVFKERNYDQIVSVESIRKTAYKIVRLVINTMQGEETLDIKTDEADEISHLIGQYMFVTGGAEERGSTEL
Protein: Pachytene checkpoint protein 2 (P38126)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the pachytene checkpoint, the meiotic checkpoint that prevents chromosome segregation when defects in recombination and synaptonemal complex formation occurred. Represses meiotic recombination in the rDNA, probably by excluding the meiosis-specific protein HOP1 from the nucleolar region.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10319812}. Chromosome {ECO:0000269|PubMed:10319812}. Note=The majority of the protein localizes to the nucleolar region containing the ribosomal RNA genes (rDNA), a tandem array of 100-150 repeats on chromosome XII. Localization is SIR2-dependent.
Interaction partners:
- Mitotic spindle checkpoint component MAD2
- Meiotic recombination protein DMC1
- Synaptonemal complex protein ZIP1
- DNA polymerase zeta processivity subunit
- Meiosis-specific protein HOP1
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Meiosis-specific protein SPO11
- Protein ZIP2
- Origin recognition complex subunit 1
- DNA repair protein RAD51
Sequence:
MSYIVDLQVRGSSLRVIKCMFREDEQISSLHSGSDSKQNSNKKLGEFLNLLKAVVKRKLESFPKDRLKTSIITGQELMREGQGSIEIKDPPTEAQQHLIRSLAKVLLHQFSSINGKVNTVNEGQDNLFLSLFVKKISIEQQSTSHVSIKLNFHEKINLGQHIDSILDSEETNESDTYHMGSVDEFIIYPFCCLEEQDELKNGSILSTEFDKIDLELDEDDGFEGETLNNCINSVGNFDIPLSKQTLNLVNISYLPGTTFEGQWESLYFGNNIKERLYSYATISLKIARFKQTGDSNQEDITTLITNNKLLLVHGPPGTGKTTLCKALCQKLSVRREFSDGSDTIDTNYKGIIIELSCARIFSKWFGESSKNISIVFKDIEELLKVNEGRGIFICLLIDEVEAIASSRTNLSSRNESTDGIRVVNTLLTQLDRLKKYHNFLALATSNLLDSLDDAFVDRADGVFYVGNPTAEGILHILKVCIEEMITSGIILFHARSTGVKFFNKYQDILRKIAIKCSTVDISGRTIRKLPLMCLSEYFRTFPVDDDEFVLALAMSARKLSAARK
Protein: Calcium-transporting ATPase 2 (EC 7.2.2.10) (J9VQQ3)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity). Transports calcium to the vacuole and participates in the control of cytosolic free calcium.
Subcellular location: Vacuole membrane {ECO:0000250|UniProtKB:P38929}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361146}.
Interaction partners:
Sequence:
MSRNNPPPVIITTDPDSPALHSAPSTPPPNQRPTPTLVIPGSPASESSHPESPQGNDPFRLSPNARLYPPGSGHSPTPSYSSALTPPSPTLTSSSSVHFSDELPTPSSPNPKTSLALRDNHPDARSGMETLQTVDENDPQRRHARGWSIGTWSSAAPTADGYSMKKPLIRTATGASEVDGDRGEDDANKKGKKDKKGKKGKKDKEEPPSAHLDPDKDKTDPTPFREKPSRLAMLVDPKSLEDLEKIGGVSGLLEGLGVDGEKGLAVGTDEGNAENGAPRSSADMPGGNGPQWRASMDRRRDIYGRNDLPRRKSKSLLLLMWLAFKDKVLILLSVAAVVSLALGLYQDLGTPPKIIYNDECPDGCEEAQVDWVEGVAIVVAIIIVVLVGSINDWQKERQFKKLNEKREDRNVKVIRGGSEMVINVKDVVVGDVCLLEPGEIIPVDGIFLRGHNVRCDESGATGESDAIKKFSYDECIKERDNLQPGQRQKKDCFLISGAKVLEGVGEYVVIAVGPTSFNGRIMMAMRGDADETPLQIKLNHLAELIAKLGGASGLLLFIALMIRFFVQLKTNPDRSANDKAQSFIQILIIAVTLVVVAVPEGLPLAVTLALAFATKRMTKQNLLVRVLGSCETMANATVVCTDKTGTLTQNEMTVVAGSLGVHGKFVKDLSDNASRSNANEGEGHSVHGDFSFDMSQLNDYASSSLQTLFNEAICINSTAFEDKNEEGKLNFVGSKTETALLRFAKDMEWPNYRQVRESAEIVQMIPFSSELKAMGVVVRKDDTYRLYLKGASEVLSNNCTRHVVVHQDGNKGDDIETTEFDDDTMSNISKTIIFYANQSLRTIALCYRDFESWPPAGTEKDGADEVPYEAIAKDMTLIAITGIEDPLRPGVREAVEKCQLAGVAVKMCTGDNVLTARSIASQCGIFTAGGVVMEGPLFRKLSDSDRLEIAPRLQILARSSPEDKRLLVKTLKSMGEVVGVTGDGTNDGPALKLANVGFAMGIAGTEVAKEASDIILMDDSFKNIVLAIMWGRCVNDSVKKFLQFQISVNITAVFITFISAVASSSEESVLTAVQLLWVNLIMDTFAALALATDPATESSLDRKPDRKNAPLITVEMFKMIMVQAIYQIIVCLVLHFAGLKILGLEDNDQNNTELGALVFNCFVFCQIFNQLNCRRLDRKLNVLEGFWRNWYFIIIFLIMVGGQILIVEVGGAAFQVTRLGGRDWGITLVIGALSLPIGALVRLTPTGPFARLLVKLHIYADPNKLPELSPEAEEEQYSYNPALSRVKDNLSTYARIRGGRLRASSMVAKSRNAQLRDADIQFPSLLTMVPTVIAGTVGAGAHWVTPHNSIGLSNPAGQDPSYSTAELFKGKVQLHPRTNPDDPLYAKFGLQPPESRGSSVSGAEGLSSGDANNV
Protein: Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) (Q8VHE0)
Organism: Mus musculus (Mouse)
Function: Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Interaction partners:
- Translocation protein SEC62
- Protein transport protein Sec61 subunit alpha isoform 1
- Protein transport protein Sec61 subunit beta
- Protein transport protein Sec61 subunit alpha isoform 2
- Protein transport protein Sec61 subunit gamma
- Protein transport protein Sec61 subunit beta
- Endoplasmic reticulum chaperone BiP
- Hypoxia up-regulated protein 1
- Glucosidase 2 subunit beta
- Ankyrin repeat domain-containing protein 45
Sequence:
MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLKPQPNIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLSLKYHPDKGGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILVLLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFDPQYNKDSTSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQEMVNVICQLIIMARSREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHSLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPTEDGQSDANKIKAKGGWQQKNKGPKKMPKSKKKKPLKKKPTTVPLPQAKQQKQKQANGVVGSEAAIKEEEDDISDKGSDSEEEETNRDSQSEKEDGSDRESDREQDEKQSKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEGGD
Protein: Tudor domain-containing protein 1 (A9CPT4)
Organism: Oryzias latipes (Japanese rice fish) (Japanese killifish)
Function: Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.
Interaction partners:
- Piwi-like RNA-mediated silencing 1
- Piwi-like protein 2
- Ankyrin repeat, SAM and basic leucine zipper domain containing 1
- RNA helicase
Sequence:
MNELRMPNLVRPNRPLREPASRPLTPSRFPVPSQPDAAYTGSAAGSTGLGSPGPAIMDGSTSFGLVQPAPTAHFCHYCGQQGIFRCKGCKKTPYCSVDCQREDWKAHRHMCKSFDPETVGENMKESPDSDNVREDSLNIQRIYLKDLNATKYTKGAEIQGAVVEFNSPGRFFFLPEDPKVMEALMSITAEXQKXPSSTVGTPYVPCVGEVCSVQFSXDLNWYRGLIQTLAADQKTAHVLYIDYGNAENVPVERIKPLNIATKPYCPCAMECQXAGVVPIVDSWSTECCMTVRQLLGGKTLTIKLVDTLKNGRVHTVDIQLSIGKQLSTFLLEQGYAFAEAAAVGSAPAKKDPSALLEASMENFKRCCEGKDINEWAQPPEPLTLTIGDRFSVVVSHFQSPTDFIVQKVENAGVIQDLQLKLREHCSGVETQQDFRPAPGTVCCAQFSEDKQWYRAQVLAYSTEKSVCVGYIDFGNSEEVDLNHLRPISPALLALPKQAISCILAGVQPVEDSWSEECISTMLRMIANKTVNVEIQSAHKGKALVAIIEGEGYSEINVAELLISANYAAPADSNTLQQTEETTASAEPPASPPVCEPLVWSCVELPSDGQTVVLSTSAVTSPAEFYCCVGPTTDHQVLMELGVQLKQHCQSDSTYFVPKVGEPCCVKFSGDGKWYRAMVKELLGDVVKVNFVDFGHNMIVGKGCLRSITPKLLKLPFQAVRCWLAGVKPAGSEWSSEALLWFQNLVDGAQLLARVVSVSQQGYGVELESGGQSVAAALVSQQFAKPSGNLSKDPVRSPTTKQEDLRGGDQSQALTPASNDTQAVCEDGKSEEEPSEVATFSSAWKTAELPLNETFQPCVAAVINPTLFYLLHPIQNVDQQKLQEVMLELALHCSNYQSSSSVDTRPVPGAACCAQFSVDKIWYRAIILEVGEAEMSVVYADYGNSEKVPVSQILPIPTRLLQLPFKIIRCTLAGNEHFPVEWPPQVQQVFRSELLNVMATVQSFDGSANVLSLALPPERGGRNLAAVIQEMLHVHRKGSPLPDASQTPGSDATEPSCIKLGSTTASPDEPEDAAEPADAVTNTQESTPQEQKEMDQATSVHDLQGPGCCCQSLKKQMDRLEKMVQLLLSLQAEG