wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear protein localization protein 4 (Q9P780)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localizes mainly at the nuclear periphery and the endoplasmic reticulum membrane. {ECO:0000250}.
Interaction partners:
- Ubiquitin fusion degradation protein 1
- Cell division cycle protein 48
- UBX domain-containing protein 2
- Uncharacterized derlin-like protein C365.08c
- Ubiquitin homeostasis protein lub1
- Uncharacterized derlin-like protein C1687.17c
- Ubiquitin conjugation factor E4
- Putative ubiquitin thioesterase otu1
- Polyubiquitin
- UBX domain-containing protein 10
Sequence:
MILRFRSKRGMARAEFQPTDTLAMLSAKILSDILKNDYSPENVSLCQNESDQGVIFSNLNDQTLQDAGLTHGQMLYLRLGTPNSDIASSNNEPALTVTGAPKQVSTPDVSEKKPSMPVIQDPIDDSLEKEDGLIRRSMTSLCRHGPKGMCDYCSPLEPYDESYRQENKIKHLSFHAYLRKINSNVNKYASSQSFIPPLEEPSFTVKEKCPSGHPPWPAGICTKCQPSTVMLNLQPFRVIDHIEFASPGIVDSFLNKWRQSGFQRIGYTYGHFEQYNNVPLGIKGVIEAIYEPPQVSEADGVTLEEWADEALVEQVATACGLRRIGIIFTDLTDDGSNSGKVLCKRHSDSYFLSSLEVYNSANFQTKFKNPCKWSRSGYFGSKFVTSVISGNLNGEIEVMSYQVSNIGTALYQADLIQPSVDPDRMLVKKEDQTRYVPDVLYRYTDKYGKQVSENAKPAFPVSFLLVTLTDGFPEKPDPLFSNNDTSIITTLESTDETGRLRQLAKLFDHNAIANGSLSNFSVLLAIAKLSILGKDDLAALASYATAPTEENEKNLNSRESYQTLLAILYSSL
Protein: Transcriptional regulatory protein SAP30 (P38429)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transcriptional regulatory protein PHO23
- Transcriptional regulatory protein SIN3
- Histone deacetylase RPD3
- Transcriptional regulatory protein SDS3
- Transcriptional regulatory protein RXT2
- Transcriptional regulatory protein DEP1
- Transcriptional regulatory protein UME1
- Histone deacetylase complex subunit CTI6
- Transcriptional regulatory protein RXT3
- Transcriptional regulatory protein UME6
Sequence:
MARPVNTNAETESRGRPTQGGGYASNNNGSCNNNNGSNNNNNNNNNNNNNSNNSNNNNGPTSSGRTNGKQRLTAAQQQYIKNLIETHITDNHPDLRPKSHPMDFEEYTDAFLRRYKDHFQLDVPDNLTLQGYLLGSKLGAKTYSYKRNTQGQHDKRIHKRDLANVVRRHFDEHSIKETDCIPQFIYKVKNQKKKFKMEFRG
Protein: Heat shock protein 60 (G8JYF5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLRLARKGLQTAVVRSYAKDVKFGAEGRQAMLVGVNLLADAVSVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIDLKDKYQNLGAKLIQDVANKANEEAGDGTTCATVLARAIAKEGFESIRQGGNAVEIRRGVMNAVEVVVAELKKISKKVTITKDDTLLLRGRGDQTEIEKRIEHITDEIEQSTSDYEKEKLNERLAKLSKGVAVLKIGGGSEVEVGEKKDRVTDALCATRAAVEEGIVPGGGVALLRSLTALKNYKAANEDQQIGVNIVKKALTQPIATIVKNAGLEPSSIIDEVTGNSNTSYGYDALNGKFVDMFEAGIIDPTKVVRTALQDASGVASLLATTECVVTEIPKEEAVGGPAGGMGGMGGMGGMGGMGF
Protein: Probable beta-tubulin polyglutamylase (EC 6.-.-.-) (Tubulin-tyrosine ligase family protein 6A) (Q23MT7)
Organism: Tetrahymena thermophila (strain SB210)
Function: Probable tubulin polyglutamylase with a strong preference for beta-tubulin.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15890843}. Cell projection, cilium {ECO:0000269|PubMed:15890843}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:15890843}. Note=Associated with microtubules from cilia, basal bodies and cell body.
Interaction partners:
Sequence:
MSQKDIYNKYSNQSADDQQEEDDDENQESSCQLSPEKDLGESLQGEDLDEDQGVIGEDDEEQEESYDEEDEEEDDEENNQDQQNNSESNLQYDKTNQKNQQTEMTDNQNEFLAEDYLSQIKTNEKSELKYQLDIQSNLSGENVQDMDEKLKQYIELNGKNENQQAAESKKIENDEIMKKSEENVHEKVVDNNQKLNIQQNNINDYQEDIKKDQSNNLVDIQQNNEIIKEVNSEDQQQKNEMDNKQSDIVLAQEESKQSEQVEAPIVKQKKIELRPKVIYDPKNDVDQYTGDYSDSGESDEEANNEDDDEDEDDESENESRSRKNKAQLLKKKNNKKEQAKKQQVKKVYKKQTLVLNVADTKYPVVKFVGKKIFKWKLAYDMESMDFDIFWTDNAVQPEQLGRMQPYQKINHFPGMFSLARKNHLARNLMKMRKQFPDQYKFFPQTWLLPAEYNDFKNQFEKSRSQQKIFIVKPEASCQGRGIFLTRSLDDLNPSDHYVVQRYLNKPYLIDGLKFDFRLYVLLAGCDPLRIYLYYEGLTRFATEKYQEVNRDNIEDMCMHLTNYAINKDNPNFKFNKDKEKMDVGHKRSLTSVLQLLEDQGHDVNKLWKDIKRVLIKTIISAQPTLAHHYKSCQPDNFMNNMCFEILGFDIILDSHLKPWVLEVNHTPSFSTDTPLDSYIKKNTIRDSLKLMNCTCKAKNEIINQRKEIMQKRVLTGKKVKYTPEEKLEEIKKAQQKRDEYEDKHLGGFERIFPMEDDEDDNFTEYMQYALKCYEEQTGANIRRNTKKVTEDPKKITNQPKKLNQPKDLEKIYNTKIGAKLPPRKPNSQTTINKGIPGQNGQRPSSSQLNEEGETIQCEDQEQNKDEAIENAITRSASGRMHDFRIKKQNSPYNIHQKFKNKIQNRVAIGVKELKLAEEPFQFEENINGKPSNPNVKKIQAYITSEKEQLEIKNMNILQDQNYNSSRAVQAKKPQIEPQVLFVQEPQTKKLQILNQAKPPQQKLQFQLIDNTAAQMEEERRQWLIQAQRNLQYQLSQQQYQPQQKLTLLPKGPPIHPQTNVMQSIADIPNSSNSKEILAAVGGAISGQYKTDKRVTIKQKGQIQNQSINQLKDNNGLFLQPKLFEIQSFQSSQQQQAQQAIQSSLDQNLIGINQNMVGLNDLFVSGKSHKVQPHYQAQQDSYSYQKHNSYSNYYQK
Protein: E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Macrophage erythroblast attacher) (B4DVN3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
Interaction partners:
Sequence:
MWTLRATGREVGSSSCEDTVAPVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSGCPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAFPPDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEKVYIM
Protein: E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) (Q5XPI4)
Organism: Homo sapiens (Human)
Function: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:27312109}.
Interaction partners:
- Ubiquitin-associated domain-containing protein 1
- Ubiquitin carboxyl-terminal hydrolase 19
- Nuclear factor NF-kappa-B p105 subunit
- Cyclin-dependent kinase inhibitor 1B
Sequence:
MASKGAGMSFSRKSYRLTSDAEKSRVTGIVQEKLLNDYLNRIFSSSEHAPPAATSRKPLNFQNLPEHLDQLLQVDNEEEESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYRPLQDPPSADLVRAQRLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHFAPLLRKVYLVEAVLMSFLLGIVEKGTPTQAQSVVHQVLDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPIVPDLGLQIHYLRLTIAILRHEKSRKFLLSNVLFDVLRSVVFFYIKSPLRVEEAGLQELIPTTWWPHCSSREGKESTEMKEETAEERLRRRAYERGCQRLRKRIEVVEELQVQILKLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNMPMLCPPEYMVCFLHRLISALRYYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKANIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALAVGGPLPLPRPGWLSSPTLGRANRFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDIEGSHWNEGLLLGRPPEEPEQPLTENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADARIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWRGCGFGYRYTRLPHLLKTKLEDANLPSLQKPCPSTLLQQHMADLLQQGPDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMTITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPILVAVTGILVQLLVRGPASEREQATSVLLADPCFQLRSICYLLGQPEPPAPGTALPAPDRKRFSLQSYADYISADELAQVEQMLAHLTSASAQAAAASLPTSEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVEDWEKGANTSTTSSAA
Protein: 18 wheeler (A1ZBR2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- LD20892p
- Latrophilin Cirl
Sequence:
MPATSSIITIIAVAACLLLLVADAHAQQQCNWQYGLTTMDIRCSVRALESGTGTPLDLQVAEAAGRLDLQCSQELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRLLTCDRYFWEKLRYAIPIELSPRGNNYTLDHHERFKQPVSPGMIFRQAPPPPAYYCTEEMEANYSSATTATPSPRPTRPGGAARIVDSMPMPMRPPSEHIYHSIESEYSAYDQHEALSMIPTGLMHQHQQQQLRLHQQQQQQQQQRLLQPQFRAMPQQAIPAPSAPVHLRSGSGLSQASTSTQSTAQASTSAAAAQQQQQQQQQQAAGSEAANKNGQAFLV
Protein: DNA repair protein recA homolog 2, mitochondrial (Recombinase A homolog 2) (Q8RY99)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in recombination ability and DNA strand transfer activity.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12768414}.
Interaction partners:
- DNA mismatch repair protein MSH1, mitochondrial
- Protein OSB1, mitochondrial
- DNA polymerase I B, chloroplastic/mitochondrial
- Single-stranded DNA-binding protein WHY2, mitochondrial
- ATP-dependent DNA helicase homolog RECG1, chloroplastic/mitochondrial
- Single-stranded DNA-binding protein WHY3, chloroplastic
- DNA repair protein RAD51 homolog 3
- DNA repair RAD52-like protein 1, mitochondrial
- DNA repair protein XRCC3 homolog
- Protein OSB4, chloroplastic
Sequence:
MGRLSWASPIQRFRFFSYLSQLNGRRSVLACSGYENRYLSSLVEASDCELDEVPDDRKVAEKDTALHLALSQLSGDFDKDSKLSLQRFYRKRRVSVISTGSLNLDLALGVGGLPKGRMVEVYGKEASGKTTLALHIIKEAQKLGGYCAYLDAENAMDPSLAESIGVNTEELLISRPSSAEKMLNIVDVLTKSGSVDVIVVDSVAALAPQCELDAPVGERYRDTQSRIMTQALRKIHYSVGYSQTLIVFLNQVRSHVKSNMHFPHAEEVTCGGNALPFHAAIRLKMIRTGLIKTANKISGLNVCVQVVKNKLAPGKKKSELGIHFGHGFYVEREVLELACEHGVILREGTSYFIEGEVIEGKDAAEKYLVENKEALDTVVAILRNQLFKM
Protein: DNA-binding protein-like (Nuclear factor kappa-B-binding-like protein) (Q9LZU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Actin-related protein 5
- RuvB-like protein 1
- Protein EIN6 ENHANCER
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin carboxyl-terminal hydrolase 2
- Actin-related protein 4
- Actin-related protein 9
- Actin-related protein 6
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- RuvB-like helicase
Sequence:
MAIEKSNVKVSRFDLEYSHGSGDSMSSYEERRKNSVVNNVDSEDEDDDFDEDDSGAGSDDFDLLELAETGAEFCQVGNVTCSIPFELYDLPSLEDILSVDVWNECLTEKERFSLSSYLPDVDQLTFMRTLKELFEGCNFHFGSPVKKLFDMLKGGQCEPRNTLYLEGRSLFLRTKHYHSLRKYHNDMVVNLCQTRDAWTSCKGYSIDEKLRVLNIVKSQKTLMREKKDDFEDDSSEKDEPFDKPWGRKGKDRKSTQKKLARHAGYGVDSGLEFPRRQLAAVEQDLYGKPKSKPKFPFAKTSVGPYATGYNGYGMNSAYNPSSLVRQRYGSEDNIDDDDQDPLFGMGSRRDREKPGYSRPGKKHKSSRDGEPISEHFMGPPYSSRQYHSNYSKSSRYANNIQPHAFADQMKPVKGSLADLRGDLYRHGKNHGDGFSVDPRYISDDLNSKSKKLKSERDSPDTSLRSYRASMQQMNERFLNSDFGENHVQEKIRVNVVPNARSGVAAFRDSRMFMGNDDTESDSSHGYDDEEERNRLMRNKSSVSVGGMNNSHFPILKSRQDIKKSKSRKKDMQENELLDGRSAYLKYLGVSGEHIYAPGTEKHSFKSKQKGKMRDRSPLENFSSRDFEDGPITSLSEFQDRNNRKEFFRSNRNSQTREQMIDRTLFQRPSAKPNLSGRKRVFDEDDESHEMRTLVNARDRLSRKYQVSEDDGNSGDENLEARLFVSCNALSKKRKTRESLMDMERREDNGDLQLYPDIQLPVGDVTVSKRKGKKKMEVDVGFLDLETSDIPKASEAEVETKPQKKPFVLITPTVHTGFSFSIVHLLSAVRMAMTSLRPEDSLDVSKSVAVENAEHETGENGASVPEEAEDNKSPQQGNGNLPSLTIQEIVSCVKSNPGDPCILETQEPLQDLIRGVLKIFSSKTSPLGAKGWKPLVTFERSTKCWSWIGPVLGPSDQETVEEVTSPEAWSLPHKMLVKLVDSFANWLKTGQETLQQIGSLPEPPLSLMQCNLDEKERFKDLRAQKSLSTITQSSEEARAYFRKEEFLRYSIPDRAFVYTAADGKKSIVAPLRRGGGKPTSKARDHFMLKRERPPHVTILCLVRDAAARLPGSIGTRADVCTLIRDSQYIVEDVSDSQVNQVVSGALDRLHYERDPCVQFDSERKLWVYLHRDREQEDFEDDGTSSTKKWKRPKKEAAEQTEEQEAVTVAFLGNEEQTETEMGSEPKTGEPTGLDGDQGATDQLCNETEQAAEEQDGENTAQGNEPTIWEPDPAVVSNPVEDNTFICQENSVNDDFDDET
Protein: DNA-directed RNA polymerase subunit Rpo5 (EC 2.7.7.6) (DNA-directed RNA polymerase subunit H) (Q980Q9)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00025}.
Interaction partners:
- DNA-directed RNA polymerase subunit Rpo7
- DNA-directed RNA polymerase subunit Rpo11
- DNA-directed RNA polymerase subunit Rpo1C
- DNA-directed RNA polymerase subunit Rpo10
- DNA-directed RNA polymerase subunit Rpo3
- DNA-directed RNA polymerase subunit Rpo1N
- DNA-directed RNA polymerase subunit Rpo12
- DNA-directed RNA polymerase subunit Rpo6
- DNA-directed RNA polymerase, subunit B''
- DNA-directed RNA polymerase subunit Rpo2
Sequence:
MRGSSNKKIDPRIHYLVPKHEVLNIDEAYKILKELGIRPEQLPWIRASDPVARSINAKPGDIIRIIRKSQLYGEVVSYRYVISG
Protein: Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3) (F6RG56)
Organism: Callithrix jacchus (White-tufted-ear marmoset)
Function: Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (By similarity). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (By similarity).
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:29019979}; Multi-pass membrane protein {ECO:0000269|PubMed:29019979}. Early endosome membrane {ECO:0000250|UniProtKB:Q8TDD5}; Multi-pass membrane protein {ECO:0000269|PubMed:29019979}. Late endosome membrane {ECO:0000250|UniProtKB:Q8R4F0}; Multi-pass membrane protein {ECO:0000269|PubMed:29019979}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q8R4F0}; Multi-pass membrane protein {ECO:0000269|PubMed:29019979}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q8R4F0}; Multi-pass membrane protein {ECO:0000269|PubMed:29019979}. Note=Recycles between the plasma membrane and intracellular compartments by a dynamin-dependent endocytic pathway (By similarity). In the cochlea located at the base of stereocilia near the position of the ankle links (By similarity). {ECO:0000250|UniProtKB:Q8R4F0, ECO:0000250|UniProtKB:Q8TDD5}.
Interaction partners:
- Mucolipin TRP cation channel 2
- Mucolipin 1.
- ADP-ribose pyrophosphatase, mitochondrial
- ADP-ribosylation factor-like protein 8B
Sequence:
MANPEIVISSCSSHEEENRCNFNQHTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTVAFKHLFLKGYIDRMDDTYAVYTQSDVYDQIIFAVNQYLQLYNVSVGNHAYENKGTDQSAMAICQHFYKRGNIYPGNDTFDIDPEIETDCFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHNMMIFDAFVILTCLVSLILCIRSVISGLQLQQEFVNFFLLHYKKDVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHNKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKHYQQDGFPETELRTFISECKDLPNSGKFRLEDDPPVSLFCCCKK
Protein: Nuclear receptor subfamily 4 group A member 2 (NUR-related factor 1) (Nuclear orphan receptor HZF-3) (Orphan nuclear receptor NURR1) (Regenerating liver nuclear receptor 1) (RNR-1) (SL-322) (Q07917)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). May confer liver-specific regulation of delayed-early genes induced later in the G1 phase of regeneration along with HMR.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P43354}. Nucleus {ECO:0000250|UniProtKB:P43354}. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization. {ECO:0000250|UniProtKB:P43354}.
Interaction partners:
- Pituitary homeobox 3
- Period circadian protein homolog 2
- LIM homeobox transcription factor 1-alpha
- Tyrosine 3-monooxygenase
- Protein FosB
- Synaptic vesicular amine transporter
- Alpha-synuclein
- LIM homeobox transcription factor 1-beta
- Nuclear receptor subfamily 4 group A member 3
- Homeobox protein engrailed-like
Sequence:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPSTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSRPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQDPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
Protein: ATP-dependent RNA helicase (EC 3.6.4.13) (K7EN69)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCHTRELAFQISK
Protein: DSC E3 ubiquitin ligase complex subunit 3 (Defective for SREBP cleavage protein 3) (Q12015)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control. Involved in endocytic protein trafficking.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21777356}; Multi-pass membrane protein {ECO:0000269|PubMed:21777356}.
Interaction partners:
- DSC E3 ubiquitin ligase complex subunit 2
- Transmembrane E3 ubiquitin-protein ligase 1
- UBX domain-containing protein 3
- Vacuole localized DSC protein 1
- Golgi/endosome-localized DSC protein 1
- Uncharacterized protein YBL029W
Sequence:
MSAEPLLPTHNGSQGGEVRSPDQKFIVIRFSDVSVRDLQLNISNVPFSNINTHWLRRMCRELRPQQTQKRRLKFIRNGSILNTHSKIAEELTHYFDTANNSNVATGTSVAPEQNNYYIHCIIGTEELTQAELANEDLKDDATPSNDSMTTQAIGFDRLRSVGFTEQEIELLRQQFRATYGDLEEEEERLAQNGNRDDEGHDIRQLEEQWMESGSGTAQGNGAGGGNEDRFNSVPIANIKHNKDLLLGICVGFFFGVFGILLMKFDGLFNRRQKMAIFAGVIVNVMFCLVRGF
Protein: Vacuolar cation/proton exchanger 1 (Ca(2+)/H(+) antiporter CAX1) (Ca(2+)/H(+) exchanger 1) (Protein CATION EXCHANGER 1) (Protein RARE COLD INDUCIBLE 4) (Q39253)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase. Involved in ion homeostasis in association with CAX3. May play a role in cold-acclimation response.
Subcellular location: Vacuole membrane {ECO:0000305|PubMed:12566577}; Multi-pass membrane protein {ECO:0000305|PubMed:12566577}. Note=Tonoplast.
Interaction partners:
- Cation/calcium exchanger 5
- CBL-interacting serine/threonine-protein kinase 24
- Two pore calcium channel protein 1
- Putative calcium-transporting ATPase 11, plasma membrane-type
- Calcineurin B-like protein 10
- Calcineurin B-like protein 4
- Monothiol glutaredoxin-S14, chloroplastic
- Sodium/hydrogen exchanger 1
- Magnesium/proton exchanger
- CAX-interacting protein 4
Sequence:
MAGIVTEPWSVAENGNPSITAKGSSRELRLGRTAHNMSSSSLRKKSDLRVIQKVPYKGLKDFLSNLQEVILGTKLAILFPAIPAAIICTYCGVSQPWIFGLSLLGLTPLAERVSFLTEQLAFYTGPTLGGLLNATCGNATELIIAILALTNNKVAVVKYSLLGSILSNLLLVLGTSLFCGGIANIRREQRFDRKQADVNFFLLLLGFLCHLLPLLVGYLKNGEASAAVLSDMQLSISRGFSIVMLISYIAYLVFQLWTHRQLFDAQEQEDEYDDDVEQETAVISFWSGFAWLVGMTLVIALLSEYVVATIEEASDKWNLSVSFISIILLPIVGNAAEHAGAVIFAFKNKLDISLGVALGSATQIGLFVVPLTIIVAWILGINMDLNFGPLETGCLAVSIIITAFTLQDGSSHYMKGLVLLLCYFIIAICFFVDKLPQKQNAIHLGHQAMNNVVTATGGGVFSS
Protein: LexA repressor (EC 3.4.21.88) (P37452)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Interaction partners:
- Protein RecA
- DNA polymerase IV
- DNA repair protein RecN
- Cell division inhibitor SulA
- Error-prone DNA polymerase
- Regulatory protein RecX
- UvrABC system protein A
- YebG family protein
- UvrABC system protein B
- UmuC domain-containing protein
Sequence:
MQKLTPRQAEILSFIKRCLEDHGFPPTRAEIAQELGFKSPNAAEEHLKALARKGAIEMTPGASRGIRIPGFEPHAANDDEGLPVIGRVAAGAPILAEQNIEESCRINPAFFNPRADYLLRVRGMSMKDIGILDGDLLAVHVTREARNGQVVVARIGEEVTVKRFKREGSKVWLLAENPEFAPIEVDLKEQELIIEGLSVGVIRR
Protein: Par-3 family cell polarity regulator (A0A8I3RSA7)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Interaction partners:
Sequence:
MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILDLDDTLCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSISDTNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKDEDGTEDNSRVEPVGHADTGLENISSFSLDDMVKLVQVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSHFSPDSQYMDNRGVTSAGLQALPRAPRLNHPPEHIDSHPRLLPQSTHPSGKPPSALAQAPQNIFSPNVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPSGPELPIETVLDDRERRISHSLYSGIEGLDESPTRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTTDTGTWSKAAINDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPTVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERHMNGNQEKGDKMDRRKDKAGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQDSLTSEEERIRMKQEQERIQAKTREFRERQARERDYAEIQDFHRTLGCNDELMYGGMSSYEGSMALNTRPQSPREGHTMDALYAQVKKPRNSKPSSVDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPSSRAAAQSGRHSVSVEVQMQRQRQEERDGFQQAQRQYSSLPRQSRKNASSVSQDSWEQNYPPGEGFQSAKENPRYSSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPLLPEGLHNYDSYKKGQDPTYTPPKGPFRQDVPPSPSQVARLNRIQTPEKGKPFYS