wanglab/gogpt-training-data huggingface dataset:
Protein: Mitochondrial import inner membrane translocase subunit TIM13 (Q9XH48)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex mediates the import of some proteins while the predominant TIM9-TIM10 70 kDa complex mediates the import of much more proteins (By similarity).
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:14730085}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM10
- Mitochondrial import inner membrane translocase subunit TIM8
- Mitochondrial intermembrane space import and assembly protein 40 homolog
- Mitochondrial import inner membrane translocase subunit TIM9
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import receptor subunit TOM40-1
- Mitochondrial import inner membrane translocase subunit TIM23-2
- FAD-linked sulfhydryl oxidase ERV1
- Mitochondrial import receptor subunit TOM6 homolog
- Mitochondrial import inner membrane translocase subunit TIM23-3
Sequence:
MDSYSSPPMGGSGSSVSPEVMMESVKTQLAQAYAEELIETLRTKCFDKCVTKPGSSLGGSESSCISRCVERYMEATAIISRSLFTQR
Protein: Candida glabrata strain CBS138 chromosome A complete sequence (Q6FY17)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Carbon catabolite-derepressing protein kinase
- Glucose transport transcription regulator RGT1
Sequence:
MLFSKKKEDPQAVPEASPENDFSPSLSQQDSSASPYENDVKKLEEEAEQTPIVDIPKKPASAYVTVSIFCLFIAFGGFVFGWDTGTISGFVAQTDFIRRLGQKRANGTHYLSKVRTGLVVSIFNIGCAIGGVILSKLGDVYGRKPGLIIVVVIYVVGIIIQIATIDKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHLRATLVACYQLMITLGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWAIFMISGMTFVPESPRFLVEKGRIEDAKRSIASSNKVSVDDPAVVAEVDSVQAAVEAERLAGSASWGELFSTKTKIFQRLVMGIMIQSLQQLTGDNYFFYYGTIVFKAVGLEDSFETSIVIGVVNFFSTFVGIFLVGRFGRRTCLLWGAATMTACMVVFASVGVTRLWPHGKGNGSSKGAGNCMIVFTCFYIFCFATTWAPLAFVICSETFPLRVKAKCMALAQASNWIWGFLISFFTPFITDAINFNYGYVFMGCLCFSYFYVFFFVPETKGLTLEEVNTMWEEGVLPWKASQWVPPSRRGADYDADALMHDDTPWYKRFL
Protein: Guanine nucleotide-binding protein subunit gamma (A0A1D8PQX7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- G protein subunit beta
- Guanine nucleotide-binding protein subunit alpha
- Cyclin-dependent protein serine/threonine kinase inhibiting protein
- Cst5p
- Alpha-factor pheromone receptor
- Serine/threonine-protein kinase CST20
- Serine/threonine-protein kinase CLA4
- Serine/threonine-protein kinase STE7 homolog
- mitogen-activated protein kinase kinase kinase
Sequence:
MNEQIEYQIQVIRLKRIQELTNRLKLALQRERIPASTASGLIISYVEETPDYLIPYNWSLPPDQNRFAKYKQLRNARNSSQATVGCCTIV
Protein: Uncharacterized protein (Q580T4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRLSSRCHLYEKLGRTKLGAEVLLKTRNDMRGFGKDSNFIVRFLARRRPIDFLALEVDGRLARELHPSFRIVKNACTLLLMGPVFVMLVSGMMSPTYYLLVSTNIMTVDRYNGLWEFSHWAVVLCGQLFVFIFLYDLSVYVRYPFFAYILVPMYRRLGLQRHQNVTVPLDEVRRRARAKPLGAPLSTVGKKLKNKRTGTRGS
Protein: Large ribosomal subunit protein uL10m (54S ribosomal protein L11, mitochondrial) (Q09724)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in mitochondrial genome encoded proteins translation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein uL16m
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein mL44
- Large ribosomal subunit protein bL32m
- Large ribosomal subunit protein mL54
- Large ribosomal subunit protein mL40
- Small ribosomal subunit protein bS18m
Sequence:
MRCSVAVRASSIYVKNPQLRKSFLHSNYVQLIQESPNFLILQHNNLLPREAKSLRTELKAKVPGSKLQVIRGSIFHHALKVYESIDRLSNGCVDMQKVNLIETHKKAQKIKLDIDNLFVGPLAIFTLGPKLSPEAIRGFMSVLKGYQNKILLLGIRAESKGMDPFEVENLSKIPSLEFLQSSLLSVLSSPASQLRRILDLSKANVAYTLERREPSE
Protein: Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) (P59017)
Organism: Mus musculus (Mouse)
Function: May promote the activation of caspase-3 and apoptosis.
Subcellular location: Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Gamma-aminobutyric acid receptor-associated protein
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Gamma-aminobutyric acid receptor-associated protein-like 1
- FUN14 domain-containing protein 1
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
- Peptidyl-prolyl cis-trans isomerase FKBP8
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
- Microtubule-associated protein 1 light chain 3 beta
- Prohibitin-2
- Ceramide synthase 2
Sequence:
MASSTTASLGFHYETKYVVLSYLGLLSQEKQQGPSPPGVQLDVAPQSLNPEVLLKLKSEIEEELKTLDKEVSEAFTSTGFDCHTSPVFSPANPESSIEDCLAHLGERVSQDLKEPLQKALQTILSQPVTYEAYRECTVETAVHASGWNKLLVPLVLLQHLLLELTRRGQEPLRMLLQFGVMYLEEHAAEFIIQQGGWGSVFSLEPEEEEYPGIIAEDSNDIYILPSDNSGQVSPPESPTVTTSWQSESLPVSLSASQSWHTESLPVSLGPESWQQIAMDPEEVKSLDSSGAGEKSENNSSNSDIVHVEKEEVPEEAFPGAAAPLLTQVPTVEAPEMMRAEKTSPTPSVFVELGEEELEAVTARPEAVERAEGAAQLSEERAGSRKKSHTGEAAAVRGAKSGLPAEGKAVLLFGGAAAVAILAVAVGVALALRRK
Protein: Dyschronic, isoform I (M9PFF3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Interaction partners:
Sequence:
MRLGGSGIPYDGDPLTMSAAGNDYAELCDLGPSRWSARPYGYNATAAAAASFGLGPSMGGTQSSSSVPTGGSAGLSGHHLRSSGAPGPSSFEAEDIGMAFGMISPPPGSGPYVGSSAAAGGSRVGNSTSSLRGAGGRSGLYYSPPGTSYTIVERPHSPHYYFNSAGVPTKGGSLPGRGSAYLSSSPASHMAAGTAGTLPTSTAASGRSMGQHASSNGNKKRPISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWDAYSPTGTRARRKGQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPARDLPVTADDLEIIAATGRSPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQTGSNQSSSSLSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRGSETLLPEYEPDAGGYLDGLRSHLGGLTQRVKSWYWGRPLSMQRLSAEQNGGSTTEQTHEHNPNVVPDHRGNLHITVKKTKPILGIAIEGGANTKHPLPRIINIHENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALIFLEA
Protein: Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) (P69682)
Organism: Rattus norvegicus (Rat)
Function: Involved in endocytosis.
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:14555962}. Cell membrane {ECO:0000269|PubMed:14555962}. Note=Partially colocalizes with AP-2 at the plasma membrane.
Interaction partners:
- AP-2 complex subunit mu
- Clathrin light chain B
- AP-2 complex subunit alpha
- Clathrin light chain A
- Epidermal growth factor receptor pathway substrate 15
- AP-2 complex subunit beta
- Intersectin-1
- Intersectin 2
- Adaptin ear-binding coat-associated protein 2
- Synaptojanin-1
Sequence:
MAAELEYESVLCVKPDVSVYRIPPRASNRGYRASDWKLDQPDWTGRLRITSKGKIAYIKLEDKVSGELFAQAPVEQYPGIAVETVADSSRYFVIRIQDGTGRSAFIGIGFTDRGDAFDFNVSLQDHFKWVKQETEISKESQEMDSRPKLDLGFKEGQTIKLSIGNITAKKGGTSKPRASGTGGLSLLPPPPGGKVTIPPPSSSVAISNHVTPPPIPKSNHGSNDSDILLDLDSPAPVPTSAPAPAPASTSNDLWGDFSTASSSVPNQAPQPSNWVQF
Protein: Aryl hydrocarbon receptor nuclear translocator type 1b (Q64FF8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTSANPDMSEVPSLAMTSSNGSHSNGVQKANKRQATSDYEDDEGGKLFRCDDDGGGSNDKERFARENHSEIERRRRNKMTAYITELSDMVPACSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGTYKPSFLTDQELKHLILEAADGFLFVVSCETGRVVYVSDSVTPVLNQAQSDWLGSSLYDQLHPDDVEKLREQLSTTENNNNSGRMLDMKTGTVKKEGGQATVRMSMGARRSFICRMRCGVCPVEPVSLNRLNFLRTRNRNGLGSAKDGEQQYVVVHCTGYIRSWPPAGMNLSEEEADNNQGNRFCLVAIGRLQVTCCPSDTSINNISVPVEFISRHNSQGVYTFVDHRCTATVGFQTQELLGKNILDFAHPEDQGLLRDSLQQVCLSKYNHYLHLAIS
Protein: BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1) (Q80X66)
Organism: Mus musculus (Mouse)
Function: Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9BSF8}. Cytoplasm {ECO:0000269|PubMed:18160256}. Note=Colocalizes with KCTD20 in filamentous structures. {ECO:0000269|PubMed:24156551}.
Interaction partners:
- Glutathione S-transferase theta-4
Sequence:
MAGRPHPYDSNSSDPENWDRKLHSRPRKLYKHSSSASRVAKGGVDHTKMSLHGASGGHERSRDRRRSSDRSRDSSHERAESQLTPCIRNVTSPTRQHHIEREKDHSSSRPSSPRPQRASPNGSMSSAGNSSRNSSQSSSDGSCKTSGEMVFVYENAKEGARNVRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPSHPASGNNDLDPDAQNPML
Protein: Protein CHLOROPLAST J-LIKE DOMAIN 1, chloroplastic (Q93WG3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably involved in the regulation of the fatty acid metabolic process in chloroplasts, especially chloroplastic galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG).
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000269|PubMed:22028775}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- RBR-type E3 ubiquitin transferase
- Pentatricopeptide repeat-containing protein At1g05600
- Probable protein phosphatase 2C 76
- UBP1-associated proteins 1B
- Myosin-binding protein 1
- Probable inactive shikimate kinase like 2, chloroplastic
- Uncharacterized protein At5g03900
- Zinc finger/BTB domain protein
- AT4g39960/T5J17_130
- Alpha/beta-Hydrolases superfamily protein
Sequence:
MAPALSTSCSSVMAFSTSNALRYHHPQISLRNSLRAPKSPSFVRLPLGKVLQSRIVIRAASSAAGNPQSDADFNPYEVLGVNPIEGFDKIKQTYGRKLKDAQRSGDEATAALLEKAYDKLMYAQLMNRKKGVTFGSFKVSKDIKYADKQPIIPWGPRFSRSSKNDMLINLAISVVFSAWIAIKRNVEYKPLQFMSFVFVYRIFEKLKSFEAPSSPIYNEEGEESGRGLRMGKRLLRSLSLVFGSILLASLAYTGFLNGIEYMGYSIPMVLYNNQELIVTASSAFMLYVIASFYR
Protein: 2-methylpropanoate--CoA ligase CCL4 (HlCCL4) (EC 6.2.1.-) (2-methylbutanoate--CoA ligase CCL4) (EC 6.2.1.-) (Butanoate--CoA ligase CCL3) (EC 6.2.1.-) (Propionate--CoA ligase CCL3) (EC 6.2.1.17) (M4IQQ5)
Organism: Humulus lupulus (European hop)
Function: Involved in the biosynthesis of prenylated phenolics natural products which contribute to the bitter taste of beer and display broad biological activities (Probable). Catalyzes the ligation of CoA on 2-methylpropanoate (isobutyric acid) and 2-methylbutanoate to produce 2-methylpropanoyl-CoA and 2-methylbutanoyl-CoA, respectively. Can also use propanoate and butanoate as substrates with a lower efficiency.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:23300257}.
Interaction partners:
Sequence:
MEDLKPRPASSSPLTPLGFLERAATVYGDCTSVVYDAVSYTWSQTHRRCLCLASSIASLGIENGHVVSVLAPNVPQMYELHFAVPMAGAILNAVNLRLDARTISILLHHSESKLIFVDHLSRDLILEAIALFPKQAPVPRLVFMADESESGNSSELGKEFFCSYKDLIDRGDPDFKWVMPKSEWDPMILNYTSGTTSSPKGVVHCHRGIFIMTVDSLIDWGVPKQPVYLWTLPMFHANGWSYPWGMAAVGGTNICLRKFDSEIIYDMIKRHGVTHMCGAPVVLNMLSNAPGSEPLKTTVQIMTAGAPPPSAVLFRTESLGFAVSHGYGLTETAGLVVSCAWKKEWNHLPATERARLKSRQGVGTVMQTKIDVVDPVTGAAVKRDGSTLGEVVLRGGSVMLGYLKDPEGTAKSMTADGWFYTGDVGVMHPDGYLEIKDRSKDVIISGGENLSSVEVESILYSHPDILEAAVVARPDEFWGETPCAFVSLKKGLTKKPTEKEIVEYCRSKLPRYMVPKTVVFKEELPKTSTGKVQKFILRDMARGMGSATAGASRSRM
Protein: Rap guanine nucleotide exchange factor 1 (Q8C5V7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
DNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLASYAASSFSVSYCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
Protein: Putative transcriptional activator MSA2 (MBF and SBF-associated protein 2) (P36157)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Origin recognition complex subunit 3
- G1-specific transcription factors activator MSA1
- Regulatory protein SWI4
- Ty transcription activator TEC1
- Regulatory protein SWI6
- Protein STE12
- Cyclin-dependent kinase 1
- Transcription factor MBP1
Sequence:
MVYTTPQQQQRFSSTPQSSHTLIFSPIRAPSMQTPSSLDYQSPSIVVSSSSMKVHGRSSSFGKFSLSIGQNGKATILGPINVLPTDTSKMEKPVPKKKPVTSDRVEKTRILSLLKKMRNKSSTVNKKYSKVPLKSTTSLQPAATAPSPLVSNIIKPSPKKLASPRTPNANSNLNLNFTSFQIKTGFTPNLDGILLENFTSPNTTADSQGNSASNIINNNHGSANNTNQFLFNLPLQSSPRQFRSPARLIDPLPISDWNTSLLMSPPRTTNFESANNHFNSNFAQASMLRRPSLPHIDEVIPQDSNPANYSDRSDYLSVDQNANNHNGALSEQTYNNIMKSSMISLPIEKDDATMALRKLVSRE
Protein: Protein WHI3 (P34761)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in size control and cell cycle.
Interaction partners:
- G1/S-specific cyclin CLN3
- Regulatory protein SWI6
- Protein WHI4
- Protein phosphatase PP2A regulatory subunit B
- Vacuolar protein sorting-associated protein 51
- mRNA-binding protein PUF2
- Heterogeneous nuclear rnp K-like protein 2
- Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
- G1/S-specific cyclin CLN2
- mRNA-binding protein PUF3
Sequence:
MQSSVYFDQTGSFASSSDNVVSSTTNTHNISPSHRSSLNLNTTSHPHEASGRGSASGELYLNDTNSPLAISSMLNTLALGSMPQDIASSNISNHDNNIKGSYSLKLSNVAKDITLRECYAIFALAEGVKSIELQKKNSSSSITSASLEDENDIFIIARFELLNLAINYAVILNSKNELFGPSFPNKTTVEIIDDTTKNLVSFPSSAIFNDTSRLNKSNSGMKRPSLLSQRSRFSFSDPFSNDSPLSQQQSQQQQQQPQQPQQHSTQKHSPQQCNQQQVNSSIPLSSQGQVIGLHSNHSHQDLSVESTIQTSDIGKSFLLRDNTEINEKIWGTSGIPSSINGYMSTPQPSTPTLEWGNTSASQHGSSFFLPSAASTAIAPTNSNTSANANASSNNGASNNGANQALSASSQQPMMQIGNTINTSLTSSNSLPPYGLMSSQSQHISNMVNTSDMNITPQKQNRFMQQPQPEHMYPVNQSNTPQKVPPARLSSSRNSHKNNSTTSLSSNITGSASISQADLSLLARIPPPANPADQNPPCNTLYVGNLPSDATEQELRQLFSGQEGFRRLSFRNKNTTSNGHSHGPMCFVEFDDVSFATRALAELYGRQLPRSTVSSKGGIRLSFSKNPLGVRGPNSRRGGSGNPNPNVNMLSSYNSNVGHIKN
Protein: Tachykinin-related peptide 5 (TKRP-5) (P86586)
Organism: Oncopeltus fasciatus (Large milkweed bug)
Subcellular location: Secreted {ECO:0000269|PubMed:19084564, ECO:0000305}.
Interaction partners:
Sequence:
APVMGFQGMR
Protein: Solute carrier family 25 member 16 (Graves disease carrier protein homolog) (GDC) (Mitochondrial solute carrier protein homolog) (Q8C0K5)
Organism: Mus musculus (Mouse)
Function: Required for the accumulation of coenzyme A in the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P16260}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Large ribosomal subunit protein eL18
- Ubiquitin-like protein FUBI
Sequence:
MAALVAAAALAAAEPAPAVPQAAGSGGPTSRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNRHYKHLGVLSTLRAVPQKEGYLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTFITTKLGVSGHVHRLMAGSMAGMTAVICTYPLDVVRVRLAFQVKGEHTYSGIIHAFKTIYAKEGGFLGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSYAPALLGRPSSDNPNVLVLKTHINLLCGGVAGAIAQTISYPFDVTRRRMQLGAVLPEFEKCLTMRETMKYVYGQHGIRRGLYRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN
Protein: Probable metalloreductase AIM14 (EC 1.16.1.-) (Altered inheritance of mitochondria protein 14) (P53109)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable cell surface metalloreductase. May be involved in iron or copper homeostasis (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Iron-regulated transcriptional activator AFT1
Sequence:
MKESPLITLVKRHSETHFANIKYGYYVLIISLVYLIGLALLRAFGRRTPSRSSSAFKNKIIYRLYDIDPAIHLGILFFAVLIPFYYHYSLTTQSTVYLKRLGRLSYALIPLNLFLTLRPNWFLRKNCTYTDFIPFHKWFSRIITVIGLLHGIFFIIKWAIDDNVSLKQKLILKTFNFAGFIISILVLFLLICSIGPMRRYNYRLFYIVHNLVNVAFILLTPIHSRPGVKFPFLLLNCTLLFIHIINRIVFAKSLMILNKNANYSKTNLVHVRLPRAILPDYFEPGSHIRISPYRRINPLYWLLPSHPYTIASLAEDNSIDLIIKETSTAEPGSQIESLRSNPKSFHLDQEKTYTLINSYPPSVPEECYSQGTNIAIICGGSGISFALPLFRHFFNKENVKYLKMIWLIKDYSEYELVLDYLKTNGLTFEKKLSNNKRISVFISGEYTAETRLDEITTNIDDENSEYEMGSFNNEDEDLSISNFNSENADSNDNTPETSHSPTKENGSMIEVKSKHSFTLSNELKSFNNESAQVNQNETWLFSCGPPSLLQLSKKYCNDERINFVCETYGL
Protein: Cytochrome P450 3A27 (EC 1.14.14.1) (CYPIIIA27) (O42563)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
Sequence:
MMSFLPYFSAETWTLLALLITLIVVYGYWPYGVFTKMGIPGPKPLPYFGTMLEYKKGFTNFDTECFQKYGRIWGIYDGRQPVLCIMDKSMIKTVLIKECYNIFTNRRNFHLNGELFDALSVAEDDTWRRIRSVLSPSFTSGRLKEMFGIMKQHSSTLLSGMKKQADKDQTIEVKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVSNVKKMLKFDLFNPLFLLVALFPFTGPILEKMKFSFFPTAVTDFFYASLAKIKSGRDTGNSTNRVDFLQLMIDSQKGSDTKTGEEQTKGLTDHEILSQAMIFIFAGYETSSSTMSFLAYNLATNHHVMTKLQEEIDTVFPNKAPIQYEALMQMDYLDCVLNESLRLYPIAPRLERVAKKTVEINGIVIPKDCIVLVPTWTLHRDPEIWSDPEEFKPERFSKENKESIDPYTYMPFGAGPRNCIGMRFALIMIKLAMVEILQSFTFSVCDETEIPLEMDNQGLLMPKRPIKLRLEARRNTPSNTTATTLKSPTT
Protein: ATP-dependent DNA helicase II subunit 2 (EC 3.6.4.12) (Q21829)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR016570}.
Interaction partners:
- Ku domain-containing protein
- DNA ligase IV
- Double-strand break repair protein mre-11
- Serine/threonine-protein kinase ATM
- Telomerase reverse transcriptase
- ATP-dependent helicase wrn-1
- Protein CNPPD1
- DNA ligase 1
- Breast cancer type 1 susceptibility protein homolog
- Exonuclease 1
Sequence:
MPPKKVSPGITVILIDAGSNMSVKDTETGKSAFENAINAADWIVSRKLFSKDPELFSVMAYNLDPKEYKTEVGGQTFNGVQCQNEKFTPASFDHLKFITKELQQNTEMIDPNFFKGVLGAVAVLKDQIESYPNPSGITLIVLTNGLNENIRQENFDLLVEAVSESNADLMIIGIDENPEYPASRVAELAETLEGRTYTFQNVAKMLSTFQARQKSERKYNKMWDIAPGIHLPVIFALKSEKSTALLKFKNADSEGNEMVRLEQMHVETDEVAPKDEFKSPVLEEKPKFQKNFKPVENIKTMHGYNFGKSVIMMDPEYLKEKYNDHNFNEGQTGGVLKLIQFTKRANILDSYLLDASAKTVLPALNSPKSGATKATVSLIEAMLSLRVAAICRYTFHAKSHVQLIALLPHQDEETGVFYLRSVKLPFSDDMRTLKFPKFSFDEEDEDLNKPTVAQLSAVDDLIDCMQLQEDEISSLVEGGMSDPKLQMQCHFLKSLVLHPNDTFENHSNRTNQILDQIMAPKRRVEAEHPEIFQKLGREFNLQPIQKTKRERVTVEPEDLQTMISEWTEKKQNMTQPDEVDDGASQKKKKKPNAKKLTRKEEVQMDIMEDGGASRVCSKILEMISNTCKFQPNGAVTEFFTLLVNELNVIRSVFVENSKCDEFNELLKKLKDEEDFEPFAEVLSEEKSCNPIDSSEVSMSEVSVANAAEFWEED
Protein: Mitogen-activated protein kinase spm1 (MAP kinase spm1) (EC 2.7.11.24) (MAP kinase pmk1) (Q92398)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions.
Interaction partners:
- Tyrosine-protein phosphatase pmp1
- MAP kinase kinase skh1/pek1
- Tyrosine-protein phosphatase CDC14 homolog
- cAMP-dependent protein kinase catalytic subunit
- Serine/threonine-protein phosphatase 2B catalytic subunit
- Start control protein cdc10
- Serine/threonine-protein kinase sck1
- MAP kinase kinase kinase mkh1
- Meiosis-specific cyclin rem1
- GTP-binding protein rho1
Sequence:
MDRRHRVYRVFNQEMYVEPNFKVVKELGQGAYGIVCAARNVASKDQEAVAIKKITNVFSKSILTKRALREIKLLIHFRNHRNITCIYDLDIINPYNFNEVYIYEELMEADLNAIIKSGQPLTDAHFQSFIYQILCGLKYIHSANVIHRDLKPGNLLVNADCELKICDFGLARGCSENPEENPGFMTEYVATRWYRAPEIMLSFSSYHKGIDVWSVGCILAELLGGTPLFKGKDFVHQLNLILHQLGTPDEETLSHISSSRAQEYVRSLPKQRPIPFETNFPKANPLALDLLAKLLAFDPNRRISVDDALEHPYLAVWHDPSDEPVCDSVFDFSFEYIEDANELRRVILDEVLNFRQKVRRRSHPTNPTVNIPQPAQTVPSNDNGSFNVSSSSSSQTSNKKRHDHSYNETAAIDHKSDDNRHN
Protein: Phosphatidyl-N-methylethanolamine N-methyltransferase (EC 2.1.1.71) (Phospholipid methyltransferase) (PLMT) (O74827)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03216, ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Mitochondrion membrane {ECO:0000255|HAMAP-Rule:MF_03216}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}.
Interaction partners:
- Phosphatidylethanolamine N-methyltransferase
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Phosphatidylserine decarboxylase proenzyme 3
- Phosphatidylserine decarboxylase proenzyme 2, mitochondrial
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Lysophospholipid acyltransferase
- Phospholipase D1
- Triacylglycerol lipase ptl3
- Kinesin-like motor protein 9
Sequence:
MAIFEINNSFLICAVSIALNPLLWNIAARSEYNHKTLTKLANGDSKKACYMLAACIFVAGIVRDLIYQNALKQQPTLGIFMNPLVQGIAKLIFCFGSVLVLSSMYKLGLVGTYLGDYFGFLLPERVSGFPFNVNDNPMYNGSTLCFLSTALRYGKVAGLLLTLEVFFVYRIALKFEEPFTAKIYAARDSKQAKKSE
Protein: AT5g63620/MBK5_9 (GroES-like zinc-binding alcohol dehydrogenase family protein) (Q93ZM6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- S-formylglutathione hydrolase
- Ketose-bisphosphate aldolase class-II family protein
- RING-H2 finger protein ATL8
- Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
- D-aminoacyl-tRNA deacylase
Sequence:
MAFAPILRRASAVKNLFSLTRLAVGSALSTRSLQTGASGDDSQSMGGYHVSPGGFMRGAVYREPNKPLTIEEFHIPRPKSNEILIKTKACGVCHSDLHVMKGEIPFASPCVIGHEITGEVVEHGPLTDHKIINRFPIGSRVVGAFIMPCGTCSYCAKGHDDLCEDFFAYNRAKGTLYDGETRLFLRHDDSPVYMYSMGGMAEYCVTPAHGLAPLPESLPYSESAILGCAVFTAYGAMAHAAEIRPGDSIAVIGIGGVGSSCLQIARAFGASDIIAVDVQDDKLQKAKTLGATHIVNAAKEDAVERIREITGGMGVDVAVEALGKPQTFMQCTLSVKDGGKAVMIGLSQAGSVGEIDINRLVRRKIKVIGSYGGRARQDLPKVVKLAESGIFNLTNAVSSKYKFEDAGKAFQDLNEGKIVSRGVVEIL
Protein: Angiotensin-1-converting enzyme inhibitory peptide (P84761)
Organism: Macrocybe gigantea (Giant mushroom) (Tricholoma giganteum)
Function: Inhibits competitively angiotensin I-converting enzyme. Administration to hypertensive rats at a dosage of 1 mg/kg results in a decrease in blood pressure.
Interaction partners:
Sequence:
GEP
Protein: Phosphoprotein OPG062 (Phosphoprotein F17) (P07396)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Plays an essential role in virion assembly and morphogenesis. Also plays a role in the inhibition of host immune response by dysregulating mTOR. Sequesters host RICTOR and RPTOR, thereby disrupting mTORC1 and mTORC2 crosstalk. In turn, blocks the host antiviral response in part through mTOR-dependent degradation of cGAS, the primary poxvirus sensor.
Subcellular location: Virion {ECO:0000305|PubMed:16877059}. Note=Major component of the virion comprising about 10% of the virion mass. {ECO:0000305}.
Interaction partners:
Sequence:
MNSHFASAHTPFYINTKEGRYLVLKAVKVCDVRTVECEGSKASCVLKVDKPSSPACERRPSSPSRCERMNNPRKQVPFMRTDMLQNMFAANRDNVASRLLN