wanglab/gogpt-training-data huggingface dataset:
Protein: A-kinase anchor protein 6 (Q3UHI8)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus membrane {ECO:0000256|ARBA:ARBA00004126}.
Interaction partners:
Sequence:
MLTMSVTLSPLRSQDPDPMATDASPMAINMTPTVEQEEGEGEEAVKDVGAEQQYGKPPPLHTAADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDADSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETTEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLGGLGDMTTSQAKTKSFDSWSYSEMEKEFPELIRSVGLLTVATEPVPSSCGAANEDSSQVILSEDHRGGHEEDGALEPGEQLGSTLETSSLGDTLTNAAEHPPETANQDSTSSPQLGAKKSQPGPCEMMTPKRSIRDCFNYNEDSPTQPTLPKRGLFLKETLKNERRGSDGKGRVVDLKPELSRSTPSLVEPPDRSKLCLVLQSSYPSSPSAASQSYECLHKVGIGNLENIVRSHIKEISSSLGRLTDCHKEKPRLKKPHKTLAEVSLCKIPKRGTGSGKQSENTRSSVVPTMVSPGAPKATARPATDSASTTSGDTCHQRNRGGKLPAQSKASSSSPCSHSSESSLGSDNIKSPLPLLSKSQKGSPPAPCHATQNGQVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRGETIQDIDDWELSEMNSDSEIYPTYHIKKKHTRLGTVSPSSSSDIASSLGESIESGPLSDILSDEDLCMPLSGMKKFTDEKSERPSSSEKNESHSATKSALIQKLMKDIQHQDNYEAIWERIEGFVNKLDEFIQWLNEAMETTENWTPPKAETDSLRLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLKMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEAQLCYLEAQRDAVEQMSLKLYSEQYTSGSKRKEEFADMSKAHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGLSLPNDILEKVDSINEKWELLGKTLREKIQDTMAGHSGSGPRDLLSPESGSLVRQLEVRIKELKRWLRDTELFIFNSCLRQEKEGTSAEKQLQYFKSLCHEIKQRRRGVASILRLCQHLLDDRDTCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLRKKMGKESETLNVIDPGLMDLNGMSEDALEWDETDISNKLISVHEESNDLDQDLEPMVPTVKLEETHHKDSGYEEEAGDCGGSQYTSNITAPSSPHIYQVYSLHNVEFHEDSHTQFLKSSPKFTGTVQPTVLTKSLSKDSSFSSTKSLPDLLGGSSLVRPYSCQSGDLSQNSGSESGIVSEGDNEMPTNSDMSLFSMVDGSPSNPETQHLDPQMGDAANVLEQKFKDEGECIKLSSVSQASVSPVGCVNGKAGDLNSITKHTTDCLGDELQGKHEVFTFYDYSYLQGSKLKFPMIMKQPQSEKAHLEDPLLRGFYFDKKSCKPKHQTSESQPDAPLHEKILASAPHEMGRSSYKSSDIEKALTGIQNARQLSLLSRSSSVESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFSGQMSLDVASSINEDSPASLTELSSSDELSLCSEDIVLHKNKVPESNASFRKRLNRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCLKDEDDDSSIATDDEIYEESNLMSGLDYIKNELQTWIRPKLSLSREKKRPSVTDEIKVNKDGGSTERANPSDTLDIEALLNCSIKRLSENNGNGKNPPRTHDLGTKGENKKNTYDVTKDPHVADMENGNVESTPEREKEKPEIPEASANLASNVKKISESKHDEYEALMDGSDDSSVTGKEFGPPNDRHPPQIGADPQHPERGDCTSVQNSCSGLLLETGGGSRQDSDGLKSLSNDAPSVARNAAGCCLLEQNETEESASISSSTSCCNCKPDVFHQKDDEDCSVHDFVKEIIDMASTALKSKSQPESEVAAPTSLTQIKEKVLEHSHRPIHLRKGGFYSYLSLSSHDSDCGEVTNYIDEKSNTPLPPDTVDSGLDDKEDVDCFFEACVEDEPADEEARLSSALPNESEVQDEAAKPEQMTASSSVFRDETDTVPLSGLSPQKGADDAKEGDGASHTSQGCVESAEPTTPPGKAKREGSSRKQSVSGTPEENAASAKPKIQAFSLNAKQPKGKAALYPSPQTLTCKEKLVSFHEDRHSNMHR
Protein: Sarcosine/dimethylglycine N-methyltransferase (SDMT) (EC 2.1.1.157) (Q9KJ21)
Organism: Halorhodospira halochloris (Ectothiorhodospira halochloris)
Function: Catalyzes the methylation of sarcosine and dimethylglycine to dimethylglycine and betaine, respectively, with S-adenosylmethionine (AdoMet) acting as the methyl donor. It has strict specificity for sarcosine and dimethylglycine as the methyl group acceptors.
Interaction partners:
Sequence:
MATRYDDQAIETARQYYNSEDADNFYAIIWGGEDIHIGLYNDDEEPIADASRRTVERMSSLSRQLGPDSYVLDMGAGYGGSARYLAHKYGCKVAALNLSERENERDRQMNKEQGVDHLIEVVDAAFEDVPYDDGVFDLVWSQDSFLHSPDRERVLREASRVLRSGGEFIFTDPMQADDCPEGVIQPILDRIHLETMGTPNFYRQTLRDLGFEEITFEDHTHQLPRHYGRVRRELDRREGELQGHVSAEYIERMKNGLDHWVNGGNKGYLTWGIFYFRKG
Protein: Auxin-responsive protein SAUR15 (Protein SMALL AUXIN UP RNA 15) (Protein SMALL AUXIN UP RNA FROM ARABIDOPSIS COLUMBIA 1) (Q41220)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as a positive effector of cell expansion through modulation of auxin transport.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9FJG1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9FJG1}.
Interaction partners:
- Steroid
- Auxin-responsive protein IAA19
- Protein BRASSINAZOLE-RESISTANT 2
- Auxin-responsive protein IAA5
- Protein BRASSINAZOLE-RESISTANT 1
- Protein BRASSINOSTEROID INSENSITIVE 1
- Transcription factor PRE1
- Auxin-responsive protein SAUR67
- Steroid 5-alpha-reductase DET2
- Transcription factor PRE5
Sequence:
MAFLRSFLGAKQIIRRESSSTPRGFMAVYVGENDQKKKRYVVPVSYLNQPLFQQLLSKSEEEFGYDHPMGGLTIPCHESLFFTVTSQIQ
Protein: Urease 2 (EC 3.5.1.5) (Jaburetox) (Jack bean urease II) (Urea amidohydrolase) (E6Y5X0)
Organism: Canavalia ensiformis (Jack bean) (Dolichos ensiformis)
Function: Urea hydrolase involved in recycling metabolically derived urea generated internally or externally (By similarity). Is able to impair growth of the phytopathogenic fungus Penicillium herguei, and shows entomotoxic activity by inhibiting diuresis in Malpighian tubules isolated from Rhodnius prolixus.
Interaction partners:
Sequence:
MKLSPREVEKISLHNAGFLAQKRLARGVRLNYSESVALIASQILEHARDGEKTVAQLMSIGKHLLGRRQVLPAVPHLLNIIQVEATLPNGTKLVTVHDPIANENGDLEEALYGSFLPVPSLDKFAESKEEHKIPGEIICADGRLTLNPGRKAVFLKVVNHGDRPIQVGSHYHFIEVNPYLTFDRRKAYGMRLNIAAGDSVRFEPGDHKTVNLVSIGGNKIIRGGNAIADGPVNEANCKAAMEIVCRREFGHKEEEDASEGVTTGDPDCPFTKAIPREEYANKYGPTIGDKIRLGDTDLIAEIEKDFALYGDESVFGGGKVIRDGMGQSSGHPPAMSLDTVITSAVIIDYTGIIKADIGIKDGLIASIGKAGNPDIMNGVFPNMIIGVNTEVICGEGLIVTAGGIDCHVHYICPQSLDEAISSGITTVVGGGTGPTDGSRATTCTPAPTQMKLMLQSTDDIPLNFGFTGKGSGSHPDELHEIIKAGAMGLKLHEDWGCTPAAIDNCLAVAEQHDIQVNIHTDTVNESGFVEHTIAAFNGRTIHTYHSEGAGGGHAPDIIKVCSMKNVLPSSTNTTRPLTSNTVDEHLDMLMVCHKLNREIPEDLAFASSRVREQTIAAEDILHDIGGISIISSDAQAVGRIGEVISCTWQTADKMKAERGPLQPDGSDNDNFRIKRYIAKYTINPAIVNGISQYVGSVEVGKLADLVIWKPSFFGAKPDIVIKGGSIAWADMGDPNGSIPTPEPVLMRPMYGTLGKAGSALSIAFVSKAALDLGVKVLYGLNKRVEAVSNVRKLTKLDLKLNNSLPEITVCPETFTVTVDGQALSSEAVTTLPLSQNYFIF
Protein: threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) (A0A1D8PCV0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Alanine--tRNA ligase
- leucine--tRNA ligase
- Threonine--tRNA ligase, cytoplasmic
- leucine--tRNA ligase
- Histidine--tRNA ligase, mitochondrial
- valine--tRNA ligase
- serine--tRNA ligase
- glycine--tRNA ligase
- Serine--tRNA ligase, cytoplasmic
- glutamine--tRNA ligase
Sequence:
MLISRRGPRLLSQGIYRFLSTKTKEAESSTQSNHVISSKQLLYTTDPTSPGSIFFLPHGTRILNKLIQFMKNQQTKYGFQEVVTPLIFKTKLWKKSGHWDNYKDDMFKVVGNDITKEEYTDNIEEHEYGLKPMNCPSHCMIFAKFDRSYQELPVRYSDFSSLHRNEASGALSGLTRVRRFHQDDGHIFCSMDQIDGEIKNTLELIKDTYNVFGINEIEFYLSTRPEDKFIGEIETWDIAESQLKNVLNSTAGEGNWATREGDGAFYGPKIDVLLKDAFNKKHQVGTIQLDFQLPNRFELKYVGEDGKRDHQPILVHRAVFGSLERFFAILLDHYQGKWPFWINPRQALIVPINESHVPVAEELQKKLSGNIVSCDNAIAPLTGFNFHVDIDKRGETVGARTKDAIQKGYSYLIMIGDKDIANGTFAVRSRDDRKIKNMTSDEIYKMFIALEQSYK
Protein: Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop domain-containing protein (Q57VM9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Las1-like
- Guanine nucleotide-binding protein subunit beta-like protein
- SUMO1/Ulp2, putative
- Ribosome biogenesis protein BOP1 homolog
- NLE domain-containing protein
- Pescadillo homolog
Sequence:
MRRRRQPLTAGITEVDVGEGEEKKARDGTDFPAVNICSWSVSADAIAADLGNQHEGKGDRRDVGDEADVGPPLKRFKIPDKALARIEAQAALARDNVAEQQNPAVGDDATDVIRRRKFSALKYCTEVADERDFSGVKKPLISVGRLPRHTAEQRQQLRRAQRNVKNMTSTSGPLGLFADGGDVIRFGSVGSDSSDSNPSETSSFDDEGCRTLTGNAVGRSASAAREIRNIDRHFSGYDSEDLPPVSGLLDEETEESEEYEESEESEEERKIADSGVNFGDCCAEANGGTVKVMSVKRGFGFQQQRRLQEGARSPGNQHIADEGTEIGVGNETAAGAAVSTGRCQRYGGVLFEMHINRAAAAPCHHTLLHVRNSITVQGPCCIIGFGIGEITVGGFFLGRKHITLLSDSQKVVVMPVRPLKSKSAASESLPVPKRQLHLPAADDCVVVAPPASASFCRFMGIGEPTAAGDTASERDCEADDLEMFGTVDWDWVEASVARVQEGRHAADNSCVVLVVQPYKSHEKAPTRRRYLVPRDTSSSKRENGGGRHRGKLHSDSFVEVPLFLARQPVPGVDAALLPDVVPAVVRHGSGAVVVLGSKGIGKSTLCRFLANALLSQHGVCYWLELDIGQPEFGPPGVLSLYCVSKPLLAPHESDGVDFVRGYYVGGTRLRCPVAGATALTRICGVAEQLRKRYPIIVNTHGWVLSTGRRMTVEAVRRLQPTHIIHLAKRQEEQWARFATELVDPIKGLNASVVNKRFLVHKQDGIACGAAGADSLPSSRILGLLPHAHDFRPKRSSTSAEATKSSSLPKWSGTVHTVQVVRDEGLLRKSMQPKASAIRRGMWGRYLAPIFEYYEATRLRHVKQQVSELYKGEEPIIVGGRRTTTLFTGELSHFESLVFTDVADASDLTVDFVCAALAHSVVAFSIRVISSSPAQGVAVSHKTESLTNCDAQAFHYPNCRSLVDLPDGFPITCFGIVESNEADMRSSGKIRIRLPVGRDDVHKMLSVSGEGKRVCISLACTLADRSETAAVEALF
Protein: C-C motif chemokine 27 (CC chemokine ILC) (Cutaneous T-cell-attracting chemokine) (CTACK) (ESkine) (IL-11 R-alpha-locus chemokine) (ALP) (mILC) (Skinkine) (Small-inducible cytokine A27) (Q9Z1X0)
Organism: Mus musculus (Mouse)
Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10.
Subcellular location: [Isoform 1]: Secreted {ECO:0000269|PubMed:10559234}. Nucleus {ECO:0000269|PubMed:10559234}. Note=May also be nuclear when following receptor (CCR10)-mediated internalization. {ECO:0000269|PubMed:10559234}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:10559234, ECO:0000269|PubMed:12133963}.
Interaction partners:
- C-C chemokine receptor type 10
- Atypical chemokine receptor 2
- C-C motif chemokine ligand 26
- C-C motif chemokine 5
- C-C motif chemokine 24
- Eotaxin
- C-C chemokine receptor type 7
- C-C chemokine receptor type 2
- C-C motif chemokine 2
- C-C motif chemokine 12
Sequence:
MMEGLSPASSLPLLLLLLSPAPEAALPLPSSTSCCTQLYRQPLPSRLLRRIVHMELQEADGDCHLQAVVLHLARRSVCVHPQNRSLARWLERQGKRLQGTVPSLNLVLQKKMYSHPQQQN
Protein: NFKB inhibitor epsilon (A0A8I6ASQ1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSDARKGPDEADDSQCDSGIESLRSLRSLPDPAAAPVSGSSHSGCPQPWSHAPKTDKEPEGKEDADGERADSTYASSSLTESLPLLERPEAKDPNPPTPSSPVSPAGVLSPQQLEALTYISEDGDTLLHLAVIHEAPSVLFCCLAFLPQEVLDIQNNLYQTALHLAVHLDQPDVVRALVLKGASRILQDQHGDTALHVACQRQNLACACCLLEEQPEPGRQPSHPLDLQLKNWQGLACLHIATLQRNQPLIELLLQNGADIDAQEGTSGKTALHLAVETQERSLVQFLLQAGARVDARMLNGCTPLHLAAGRGLNSISSTLCEAGADSLLLNVEDETPQDLAEDVREIHALQGRVSHP
Protein: Small ribosomal subunit protein uS3c (30S ribosomal protein S3, chloroplastic) (Q6END5)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Large ribosomal subunit protein uL2 C-terminal domain-containing protein
- Large ribosomal subunit protein uL4 C-terminal domain-containing protein
- 60S acidic ribosomal protein P1
- Small ribosomal subunit protein eS31 domain-containing protein
- 60S ribosomal protein L35a
- 40S ribosomal protein S16
- Large ribosomal subunit protein uL5c
- Ribosomal protein L22
- 60S ribosomal protein L17
- Ribosomal protein L30 ferredoxin-like fold domain-containing protein
Sequence:
MGQKINPLGFRLGTTQNHHSFWFAQPKNYSEGLQEDKKIRNCIKNYIQKNRKKGSNRKIEADSSFEVITHNKKMDSGSSSEVITHIEIQKEIDTIHVIIHIGFPNLLKKKGAIEELEKDLQKEVNSVNQRLNIGIEKVKEPYRQPNILAEYIAFQLKNRVSFRKAMKKAIELTKKTDIKGVKVKIAGRLAGKEIARAECIKKGRLPLQTIRAKIDYCCYPIRTIYGVLGVKIWIFVDEE
Protein: Mas-related G-protein coupled receptor member B4 (Q7TN45)
Organism: Rattus norvegicus (Rat)
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSPTTQAWSINNTVVKENYYTEILSCITTFNTLNFLIVIISVVGMAGNATVLWLLGFHMHRNAFSVYVLNLAGADFLYLCAQTVYSLECVLQFDNSYFYFLLTILMFNYLAGFCMIAAISTERCLSVTWPIWYHCQRPRHTSATVCALFWAFSLLLSLLLGQGCGFLFSKFDYSFCRYCNFIATAFLIVIFMVLFVSSLALLAKIICGSHRIPVTRFYVTIALTVLVFIFFGLPIGICVFLLPWIHMMLSSFFYEMVTLLSCVNSCANPIIYFFVGSIRHHRLQRQTLKLLLQRAMQDTPEEEGGERGPSQKSEDLEVVRCSS
Protein: Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) (P00940)
Organism: Gallus gallus (Chicken)
Function: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU10127}.
Interaction partners:
- Phosphoglycerate kinase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glucose-6-phosphate isomerase
- Transaldolase
- Fructose-bisphosphate aldolase B
- Phosphoglycerate mutase 1
- Fructose-bisphosphate aldolase C
- Triokinase/FMN cyclase)
- Cleavage stimulation factor subunit 3
- Alpha-enolase
Sequence:
MAPRKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH
Protein: Uncharacterized protein C24B11.08c (Q09895)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- ER-derived vesicles protein 41
- Vacuolar protein sorting-associated protein 45
- tRNA modification GTPase mss1
Sequence:
MQFRSPLRRFDAFQKTVEDARIKTASGGLITLVSGLIVIFIVLMEWINYRRVIAVHEIIVNPSHGDRMEINFNITFPRIPCQILTVDVLDVSGEFQRDIHHTVSKTRLSPSGEIISVDDLDIGNQQSISDDGAAECGDCYGAADFAPEDTPGCCNTCDAVRDAYGKAHWRIGDVDAFKQCKDENFKELYEAQKVEGCNLAGQLSVNRMAGNFHIAPGRSTQNGNQHVHDTRDYINELDLHDMSHSIHHLSFGPPLDASVHYSNPLDGTVKKVSTADYRYEYFIKCVSYQFMPLSKSTLPIDTNKYAVTQHERSIRGGREEKVPTHVNFHGGIPGVWFQFDISPMRVIERQVRGNTFGGFLSNVLALLGGCVTLASFVDRGYYEVQKLKKN
Protein: Kinesin-like protein KIF7 (B7ZNG0)
Organism: Mus musculus (Mouse)
Function: Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes. Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation. Involved in the regulation of epidermal differentiation and chondrocyte development.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:19666503, ECO:0000269|PubMed:24952464, ECO:0000269|PubMed:25644602}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:25644602}. Note=Localizes to the cilium tip.
Interaction partners:
- Suppressor of fused homolog
- Zinc finger protein GLI2
- Zinc finger protein GLI1
- Transcriptional activator GLI3
- Protein smoothened
- Glycogen synthase kinase-3 beta
- Serine/threonine-protein kinase 36
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Kinesin-like protein KIF3A
Sequence:
MGLEAQRLPGAEEAPVRVALRVRPLLPKELLHGHQSCLRVEPERGRITLGRDRHFGFHVVLGEDTGQEAVYQACVQPLLEAFFEGFNATVFAYGQTGSGKTYTMGEASVASLHEDEQGIIPRAMAEAFKLIDENDLLDCLVHVSYLELYKEEFRDLLEVGTASRDIQLREDDRGNVVLCGVKEVDVEGLDEVLSLLEMGNAARHTGATHFNRLSSRSHTVFTVTLEQRGRTPSRLPRPAAGHLLVSKFHFVDLAGSERVLKTGSTGERLKESIQINSTLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLGGNAKTVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVNWHPEAERVPEEQAAGARGPPRHRSETRIIHRGRRVPCPAVGSAAVAAGLGAECARCRARTSAAYSLLRELQAEPGLPGAAARKVRDWLCAVEGERSTLSSASGPDSGIESAPAEDQAAQGTSGRKGDEGTQQLLTLQSQVARLEEENRDFLAALEDAMEQYKLQSDRLREQQEEMVELRLRLELAQPGWGAPGLLQGLPPGSFVPRPHTAPLGGAHTHMLGMMPSTCLPGEEVSSEQQVVSGKEVKAEVLAQADKLRSASSTTSEEEGEEEEEEEEEEEEPPRRTLYLRRNGISNWSQRAGLSPGSPPDRKGPEVCPEEPAAAIPAPQAVGSGKVPVQTRQAPAAMASEWRLAQAQQKIRELAINIRMKEELIGELVRTGKAAQALNRQHSQRIRELEQEAERVRAELCEGQRQLRELEGREPQDASERSRLQEFRKRVAAAQSQVQVLKEKKQATERLVSLSAQSETRLQELERNVQLMRRQQGQLQRRLREETEQKRRLETEMNKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQQKIEEQKKWLDQEMEKVLQQRRALEELGEELRKREVILAKKEALMQEKTGLESKRLRSSQALNEDIVRVSSRLEHLEKELSEKSGQLRQGSAQNQQQIRGEIDTLRQEKDSLLKQRLEIDSKLRQGSLLSPEEERTLFQLDEAIEALDAAIEYKNEAITCRQRVLRASASLLSQCEMNLMAKLSYLSSSETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEEQQRLVYWLEVALERQRLEMDRQLTLQQKEHEQNVQLLLQQGRDHLGEGLADSKRQYEARIHALEKELGRHMWINQELKQKLSAGSTAGQSQGCERRSLCLENRQCLGNEDGLHPAAPEPLWQSSLLEGVSRVWDESRDLVHAPLPLTWKRSSLCSEQGSSEESRVRETTEPPVGRVLPMGEVGLSWNFGPLPKPRWEPRRTSPGMIDVRKNPL
Protein: Catenin beta-1 (Beta-catenin) (F1QGH7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorsoventral patterning: in prospective ventral blastomeres, its down-regulation by axin1 and axin2 leads to inhibit the Wnt signaling pathway, while in prospective dorsal blastomeres, degradation of axin results in stabilization and nuclear translocation of ctnnb1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10456847}. Nucleus {ECO:0000269|PubMed:15494018, ECO:0000269|PubMed:25371059, ECO:0000269|PubMed:26938059, ECO:0000269|PubMed:30467143}. Cell membrane {ECO:0000269|PubMed:15494018, ECO:0000269|PubMed:25371059, ECO:0000269|PubMed:26938059, ECO:0000269|PubMed:30361324, ECO:0000269|PubMed:30467143}. Cell junction {ECO:0000269|PubMed:10456847}. Cell junction, adherens junction {ECO:0000269|PubMed:10456847, ECO:0000269|PubMed:19101534}. Note=Cytoplasmic when it is un-stable (highly phosphorylated). Translocates to the nucleus when it is stabilized (low level of phosphorylation). The majority of beta-catenin is localized to the cell membrane. Localized in the ooplasm during the initial stages of oogenesis (PubMed:10456847). {ECO:0000250|UniProtKB:B6V8E6, ECO:0000250|UniProtKB:P35222, ECO:0000269|PubMed:10456847}.
Interaction partners:
- Cadherin-2
- Axin-1
- Cadherin 1, type 1, E-cadherin
- Glycogen synthase kinase-3 beta
- Lymphoid enhancer-binding factor 1
- Transcription factor 7-like 2
- ETS domain-containing protein Elk-4 isoform 1
- Glycogen synthase kinase-3 beta
- Axin-2
- Protein Wnt
Sequence:
MATQSDLMELEMAMDPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEDDDVDNQVLYEWEQGFNQSFNQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDSAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTSGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQDAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDIHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMTWNETGDLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDAMGMDPMMEHEMAGHHPGPDYPVDGLPDLGHTQDLIDGLPPGDSNQLAWFDTDL
Protein: Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 (EC 3.6.4.13) (Masculinization of germline protein 1) (Sex determination protein mog-1) (P34498)
Organism: Caenorhabditis elegans
Function: Probable ATP-binding RNA helicase involved in pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Pre-mRNA-splicing factor CWC25 homolog
- Splicing factor YJU2
- Pre-mRNA-processing factor 17
- Cell division cycle 5-like protein
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Pre-mRNA-splicing factor CWC22 homolog
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-processing factor 19
- Protein BUD31 homolog
- Pre-mRNA-splicing factor syf-2
Sequence:
MSDKRADGRLEGTSDTFGGLVIKKKKVEGDSKPTEPSGKSLLGLDRLASTKREHARKRLEDDDDRGVTESVRKGIEKVHEKHRDRDDRGMKYKSRDDDRRRDRDRSERREPSSRRGWKDRSGDQTPRFKVPDTPSRMSWDQDDREGSSRKRNSWDMPTPRGERDRKRYMDSERSISSAWRSERRNRDDEKRRRHRKPEDSVRSVKEEKAEPTFHDDEERAQWEEEQKNLDREWYDNEGAFDDEYNPFNKVSDEFVEKREKQWQEKTQKPRLTVKQQAIKRENELWENNRLHRSGVVAMADELSSIFEDETDENRVTILVQNIVPPFLDGRIVFTKQAQPIIPVVDTTCDMAVSAARGSVAVRKRREVEDRKKAQDKHWELAGSKLGNLMGVKEKKDETADPEDDDSGNYKESHQFASHMKDNEAVSDFAMEKSIKQQREYLPVFACRQKMMNVIRENNVVIIVGETGSGKTTQLAQYLLEDGFGDSGLIGCTQPRRVAAMSVARRVADEMGVDLGQDVGYAIRFEDCTSEKTIIKYMTDGILLRECLGDGSLDQYSAIIMDEAHERSLNTDVLFGLLREVIAKRADLKLIVTSATMDADKFADFFGGNCPTFTIPGRTFPVELFHARTPVEDYVDAAVKQAVTIHLGGMDGDILIFMPGQEDIECTCEMIKEKLGELDEAPPLAVLPIYSQLPSDLQAKIFQRAPGGMRKAIVATNIAETSLTVDGILFVIDPGFCKMKVYNPRIGMDALSIFPVSQASANQRTGRAGRTGPGQCYRLYTERQFKDELLKSTVPEIQRTNLANVVLLLKSLGVDDLLKFHFMDAPPQDNMLNSMYQLWTLGALDNTGQLTPMGRKMVEFPLDPTLSKMLIMSAEMGCSDEVLTIVSMLSVPAIFFRPKGREEEADAKKEKFQVPESDHLTFLNVYIQWRTHKYSAKWCADNYLHVKALKKVREVRAQLKEIMQDLKLPLISNGSEWDIVRKCICSAYFHNAARLKGIGEYVNVRTGIPCFLHPTSALFGMGFMPDYVVYHELIMTAKEYMQCVTAVDAIWLAELGPMFYSIKESKQSRKELKMESVRTVETMEAEMREAQKEMERRKEESDKAFKRPESSRRVVEVGSKSARSERRKLWGL
Protein: Protein-cysteine N-palmitoyltransferase HHAT-like protein (Glycerol uptake/transporter homolog) (Hedgehog acyltransferase-like protein) (Q9HCP6)
Organism: Homo sapiens (Human)
Function: Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Acyl carrier protein, mitochondrial
- Partner and localizer of BRCA2
- Beta-alanine-activating enzyme
Sequence:
MGIKTALPAAELGLYSLVLSGALAYAGRGLLEASQDGAHRKAFRESVRPGWEYIGRKMDVADFEWVMWFTSFRNVIIFALSGHVLFAKLCTMVAPKLRSWMYAVYGALAVMGTMGPWYLLLLLGHCVGLYVASLLGQPWLCLGLGLASLASFKMDPLISWQSGFVTGTFDLQEVLFHGGSSFTVLRCTSFALESCAHPDRHYSLADLLKYNFYLPFFFFGPIMTFDRFHAQVSQVEPVRREGELWHIRAQAGLSVVAIMAVDIFFHFFYILTIPSDLKFANRLPDSALAGLAYSNLVYDWVKAAVLFGVVNTVACLDHLDPPQPPKCITALYVFAETHFDRGINDWLCKYVYNHIGGEHSAVIPELAATVATFAITTLWLGPCDIVYLWSFLNCFGLNFELWMQKLAEWGPLARIEASLSVQMSRRVRALFGAMNFWAIIMYNLVSLNSLKFTELVARRLLLTGFPQTTLSILFVTYCGVQLVKERERTLALEEEQKQDKEKPE
Protein: Probable 6-phosphogluconate dehydrogenase,decarboxylating Gnd2 (O06574)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Glucose-6-phosphate 1-dehydrogenase 1
- 6-phosphogluconolactonase
- Glucose-6-phosphate 1-dehydrogenase 2
- 6-phosphogluconate dehydrogenase, decarboxylating
- Ribose-5-phosphate isomerase B
- Ribulose-phosphate 3-epimerase
- Uncharacterized protein Rv1518
- Alpha-pyrone synthesis polyketide synthase-like Pks18
- UPF0232 protein Rv0004
Sequence:
MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGEVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDFDIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPAPVLTTALQSRFASRDLDDFANKALSAMRKQFGGHAEKPAN