wanglab/gogpt-training-data huggingface dataset:
Protein: Octaketide synthase 1 (OKS) (EC 2.3.1.-) (Q3L7F5)
Organism: Aloe arborescens (Kidachi aloe)
Function: Catalyzes the iterative condensations of 8 molecules of malonyl-CoA to produce aromatic octaketides, SEK4 and SEK4b, the products of the minimal polyketide synthase for the benzoisochromanequinone actinorhodin. May be involved in the biosynthesis of the octaketide barbaloin.
Interaction partners:
Sequence:
MSSLSNASHLMEDVQGIRKAQRADGTATVMAIGTAHPPHIFPQDTYADFYFRATNSEHKVELKKKFDRICKKTMIGKRYFNYDEEFLKKYPNITSFDEPSLNDRQDICVPGVPALGAEAAVKAIAEWGRPKSEITHLVFCTSCGVDMPSADFQCAKLLGLRTNVNKYCVYMQGCYAGGTVMRYAKDLAENNRGARVLVVCAELTIIGLRGPNESHLDNAIGNSLFGDGAAALIVGSDPIIGVEKPMFEIVCAKQTVIPNSEDVIHLHMREAGLMFYMSKDSPETISNNVEACLVDVFKSVGMTPPEDWNSLFWIPHPGGRAILDQVEAKLKLRPEKFRATRTVLWDCGNMVSACVLYILDEMRRKSADEGLETYGEGLEWGVLLGFGPGMTVETILLHSLPLM
Protein: Rieske domain-containing protein (Q8TAC1)
Organism: Homo sapiens (Human)
Interaction partners:
- Hemoglobin subunit theta-1
Sequence:
MNLDGSAQDPEKREYSSVCVGREDDIKKSERMTAVVHDREVVIFYHKGEYHAMDIRCYHSGGPLHLGDIEDFDGRPCIVCPWHKYKITLATGEGLYQSINPKDPSAKPKWCSKGIKQRIHTVTVDNGNIYVTLSNEPFKCDSDFYATGDFKVIKSSS
Protein: Protein QmcA (P0AA53)
Organism: Escherichia coli (strain K12)
Function: Identified as a multi-copy suppressor of an FtsH/HtpX protease double disruption mutant. May play a role in the quality control of integral membrane proteins.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:16573693}; Single-pass type I membrane protein {ECO:0000269|PubMed:16573693}.
Interaction partners:
- Inner membrane protein YbbJ
- ATP-dependent zinc metalloprotease FtsH
- Probable iron export ATP-binding protein FetA
- Flotillin family inner membrane protein YqiK
Sequence:
MLIFIPILIFVALVIVGAGVKIVPQGYQWTVERFGRYTKTLQPGLSLVVPFMDRIGRKINMMEQVLDIPSQEVISKDNANVTIDAVCFIQVIDAPRAAYEVSNLELAIINLTMTNIRTVLGSMELDEMLSQRDSINSRLLRIVDEATNPWGIKVTRIEIRDVRPPAELISSMNAQMKAERTKRAYILEAEGIRQAEILKAEGEKQSQILKAEGERQSAFLQAEARERSAEAEARATKMVSEAIASGDIQAVNYFVAQKYTEALQQIGSSSNSKVVMMPLEASSLMGSIAGIAELVKDSANKRTQP
Protein: Cyclin-dependent kinase 6 (Q99MD0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
GKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF
Protein: Collagen alpha-2(I) chain (Alpha-2 type I collagen) (P08123)
Organism: Homo sapiens (Human)
Function: Type I collagen is a member of group I collagen (fibrillar forming collagen).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Interaction partners:
- Lumican
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Integrin beta-1
- CD44 antigen
- Fibronectin
- Integrin alpha-2
Sequence:
MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGPPGPPGPPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQPENIPAKNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLLANYASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK
Protein: Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1) (Q9CZN8)
Organism: Mus musculus (Mouse)
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03150}.
Interaction partners:
- Glutamyl-tRNA
- Glutamyl-tRNA
- Glutamine--tRNA ligase
- Asparaginyl-tRNA synthetase
- Asparagine--tRNA ligase, cytoplasmic
- Aspartate--tRNA ligase, cytoplasmic
- Bifunctional glutamate/proline--tRNA ligase
- Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial
- Aspartate--tRNA ligase, mitochondrial
- Endothelial transcription factor GATA-2
Sequence:
MLGRTLREVSAALKQGQVTPTELCKNCLSLIKKTKYLNAYITVSEEVALKQAEESEKRYKQGQSLGDLDGIPVAVKDNFSTTGIETTCASNMLKGYVPPYNATVVQKLLDQGALLMGKTNLDEFAMGSGSTDGVFGPVRNPWTYSKQYRERSRQDAGDDSHWLITGGSSGGSAAAVAAFTCFAALGSDTGGSTRNPAAHCGIVGFKPSYGLVSRHGLIPLVNSMDVPGILTRCVDDTAIVLGTLAGHDPKDSTTVRNPAQPASVPGGMDVSRLCIGIPKEYLVPELSSEVRSLWSQAADLFESEGAKVIEVSLPHTCYSIVCYHVLCTSEVASNMARFDGLQYGHRSGVDVSTEAMYAATRQEGFNDVVRGRILSGNFFLLKENYENYFVKAQKVRRLIVKDFVDVFESGVDVLLTPTTLTEAVPYLEFIKEDNRTRSAQDDIFTQAVNMAGLPAVSVPVALSNQGLPIGLQLIGRAFCDQQLLTVAKWFEKQVQFPVIQLQGLMDDGSLVLENGKLTSASLTQR
Protein: Calcium and integrin-binding family member 2 (Kinase-interacting protein 2) (KIP 2) (Q9Z309)
Organism: Mus musculus (Mouse)
Function: Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis. Acts as a auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells. Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing. Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells. Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea. Critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. Seems to be dispensable for vestibular functions.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23023331}. Cell projection, stereocilium {ECO:0000269|PubMed:23023331, ECO:0000269|PubMed:29084757}. Photoreceptor inner segment {ECO:0000269|PubMed:23023331}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:23023331}. Cell membrane, sarcolemma {ECO:0000269|PubMed:18611855}. Note=Colocalizes with ITGA7 at the myotendinous junctions (MTJ) and at the neuromuscular junctions (NMJ) (PubMed:18611855). Located mainly in stereocilia and at the apical surface of hair cells of the cochlea (PubMed:29084757). Localizes in the cuticular plate along and at the tip of the stereocilia of vestibular sensory hair cells (By similarity). {ECO:0000250|UniProtKB:O75838, ECO:0000269|PubMed:18611855, ECO:0000269|PubMed:23023331, ECO:0000269|PubMed:29084757}.
Interaction partners:
- LHFPL tetraspan subfamily member 5 protein
- Transmembrane channel-like protein 1
- Transmembrane inner ear expressed protein
- Transmembrane channel-like protein 2
- Protocadherin-15
- Unconventional myosin-VIIa
- Whirlin
- pre-mRNA splicing regulator USH1G
- Clarin-1
- Cadherin-23
Sequence:
MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHARFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKERIVEAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLEMTLARLTKSELEEDEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI
Protein: LIM/homeobox protein Lhx5 (LIM homeobox protein 5) (Homeobox protein LIM-5) (P52889)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probably involved in the patterning of the nervous system, in particular in the early specification of the diencephalon.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cyclin-K
- Paired box protein Pax-2a
Sequence:
MMVHCAGCERPILDRFLLNVLDRAWHAKCVQCCECNCNLTEKCFSRDGKLYCKIDFFRRFGTKCAGCLQGISPSDLVRRARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKEDYLSASAIKEVNLNSVSSCTDRSLSPDLPDQIQDDTKETDNSTSSDKDTNNNENEEQNSCTKRRGPRTTIKAKQLETLKAAFVATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRGPRRMRPLGGRLEDPDIMGPGGYSYYGEYQGDYYGPVVNYDFFPHGPPSSQAHSPAESPYLLSSGSGALEGGPVSAHHPSDDQRFTDMISHADTPSPEPGMTGPLHSNPQGEGGFTGSPPFPLANNTSYSGPMSHPGQEMGENTVW
Protein: Alkyl hydroperoxide reductase AhpD (EC 1.11.1.28) (Alkylhydroperoxidase AhpD) (P9WQB5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
Interaction partners:
- Alkyl hydroperoxide reductase C
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
- Superoxide dismutase
Sequence:
MSIEKLKAALPEYAKDIKLNLSSITRSSVLDQEQLWGTLLASAAATRNPQVLADIGAEATDHLSAAARHAALGAAAIMGMNNVFYRGRGFLEGRYDDLRPGLRMNIIANPGIPKANFELWSFAVSAINGCSHCLVAHEHTLRTVGVDREAIFEALKAAAIVSGVAQALATIEALSPS
Protein: Tetraspanin-10 (Tspan-10) (Oculospanin) (Q9H1Z9)
Organism: Homo sapiens (Human)
Function: Regulates maturation of the transmembrane metalloprotease ADAM10.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8VCF5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VCF5}.
Interaction partners:
- Nuclear protein localization protein 4 homolog
Sequence:
MEEGERSPLLSQETAGQKPLSVHRPPTSGCLGPVPREDQAEAWGCSCCPPETKHQALSGTPKKGPAPSLSPGSSCVKYLIFLSNFPFSLLGLLALAIGLWGLAVKGSLGSDLGGPLPTDPMLGLALGGLVVSAASLAGCLGALCENTCLLRGFSGGILAFLVLEAVAGALVVALWGPLQDSLEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNLYFNCSSPGVQACSLPASCCIDPREDGASVNDQCGFGVLRLDADAAQRVVYLEGCGPPLRRWLRANLAASGGYAIAVVLLQGAELLLAARLLGALAARSGAAYGPGAHGEDRAGPQSPSPGAPPAAKPARG
Protein: GH04440p (Q961V6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYTESIEDYDTLLQRNPTYLPGLRGAAEAHIGIANSLKSQNLYGRSKAHFQLALEHLQSAFLQREAQGMVWLWRLSANIFVQTAQLPHSLANLDVAGNLAKREEPIAYLSRKDLLQLAQRFYLCALKLKQNTYLWYELSLASYYSAILIPEDANGHLETATKACKMAIKECSNRWLNWNLLGVINMNSENENLPLAQHCFIQAVVLEKKCYTAWTNLGVLYIKLNEVRLANEAFTRAQQSSPVYANAWIGQAMVAELIGDREEAFDLFRHCQQFDYHPEAALGFAHWVCEMLSTPGSFDKPRIKHAIEHMYADVLALDAINWYVQNEETDATPASLSFQGFLYARKNLYRQAIEAFTRACKLCEPGADRDKLYTNLGYLYLKIDQPEQAAHALNTVAHATFKPIIGLAQAYYLAGQLQESYSIYNSVLGNVVDHGDDKAATILVAMASMIYDFQGEADTKTLLYQCVLLKEVPIQALFSALALGILHRDNALIHTILTELNAYAFKKEYCADISYLTAHYILINEGARRALCYLQTRIRMFPNSRSLRSVVLKFLLDYFSDDQSYRLATSNMGRITLTLGHTKQQNSILASEEALTTIYASQAVSAVDKTCSMKLLQRAILLSPTDQRARQLLSAIIANS
Protein: Iroquois-class homeodomain protein irx-1-A (Iroquois homeobox protein 1-A) (Xiro-1) (Xiro1) (Q9YGK8)
Organism: Xenopus laevis (African clawed frog)
Function: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds to the bmp4 promoter to repress gene expression and thus mediate down-regulation of bmp4 by wnt signaling. Controls multiple processes through bmp4-repression including neural plate development, neural crest specification and Spemann organizer development. Involved in the specification of the preplacodal field at the anterior border of the neural plate. Regulates the genetic cascade of interactions that are necessary for positioning the isthmus organizer and the formation of the midbrain-hindbrain boundary. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros. Acts principally as a transcriptional activator during pronephros development.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Interaction partners:
Sequence:
MSFPQLGYPQYLTAGQAAVYGGERPGVLAAAAAAAAAAAAAGSGRPTGAELGSSSTAAVTSVLGMYASPYSAPNYSAFLPYTTDLTLFSQMGSQYELKDNPGVHPATFAAHTTPGYYPYGQFQYGDPGRPKNATRESTGTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKEDDNIFGSDNEGDHEKNEDDEEIDLESIDIDKIDDNDGEQSNEEEDEKLEHLRQGEKESLKKESEVMIPSSDGLKPKDSMSLGKESSDTSNTRIVSPGGQGNIQVPPHSKPKIWSLAETATSPDGALKSSPPPSQGNHTSPPIQHPAFLPSHGLYTCQIGKFHNWTNGAFLTQSSLINMRSLLGVNPHHAAHHNHHHLQAHQQAPFLATNLSSLSSDKTPERTSPKHSDRENVPRTDSPPQLKPSFQAVRENTLSQQEGTSRILTALPSA
Protein: OBSCN protein (Q4KMX9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MALHSGWRNCDSCAGRWWGFSQLHGQCQAWEGSVSPTFSSRPSYPRVVFLTWAVSLTSCVPPCPSPEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQAEAGEYSCEAGGQQLSFRLQVAGQCFGDAE
Protein: Patulin biosynthesis cluster protein F (EC 1.-.-.-) (A0A075TR27)
Organism: Penicillium expansum (Blue mold rot fungus)
Function: Part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria. PatF catalyzes the conversion of phyllostine into neopatulin. The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:30680886}.
Interaction partners:
Sequence:
MKSSLWVSLAVSLIGLGPAAARNDYPGNYPSSSPPLGPTDWERTPVSVFAKVLNTQPDPDYNLLKELVTYDCTYISLTFDNPTLHGIMPWAGTHTHVGPQAFIDIFTRVGLYWDRGPFSIDHIFGDDGNVTAWGSFTATSRTLGKTVISPWAARARVNSANQIFEFQWMEDTFTTASSFGSDNSTKVFIANPEGGTAHA
Protein: Uncharacterized protein (Q389X2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLLGLKDLFIVRGGAAHRPTLQCDEDGFVVYLMLLVAYCICVCFTTWNYGRTCSPVVLETIILLARVMVGNSELLFKGDQAAAWAGFGGPHRSPNGETSSHGVGSQQRRKDRVISKPTFAPVPFFSVCAAAFLIVSAFTTLFCKTDACLLHSTRIAFGLSMVIMPATLTGRKAFMLAGGCYLVYVFWGPFALYIQQFQESGTHTWWHSLYSRYSTALALTVLLMDVRDFTQCQLGRKCVAAFPALEKLVKIIPDSSSHGDDKVWGVSISYVCFVCSITTMTLCLWASSMMLERSLDVSCTGVFCALVVVLKIADGCLAKGFMKALRESFPLLTISALLVAVVYYCVPVESHPIVAGSMPCSMVVVYIANRCPCGSYSETIFLLMWLTMFGSVYRGSSFAHVIEGRYVFPNQMLHLVTIGVGFHTLFVLGFATLTQGSHPCSGPLLPLLKRVTAILRELRLLNKGRCGRKEERNTRSSPPPQTVVERSPLRVETRGAEKNGNSTEGNLYVMSSELPSLTKLVKMEAELSAEISSTTEQPSQDDDEFFGVVHRGSTGEGVKRLECLVDHGSAVESTQGVSQHESPTATPILVHEGHFNESHMDAREEEAETTPAFEDIREMECPKKEMEEKVMIILEERQESRVRDVADQSSEMGKRKLSANGNSKATYAEAVLEDLQAETKAAKLITAQQKAQQPEESLDKQQLLRDSGLSEPKKNVLRASTSAEGSLKRSGDASERVPVGAVVKMSRQHQAAAKSKKELTVPLPKCMVTAQEMSSTPALVAADVAAERPSKKEVKHATTPKRNTAEVEAEKQKGTAKGVNQKGGKVLQDEPAKKPRAVADSLKQKEKVESRRRKDEKDPTRCTSDSKPKQFIPSLQNIGAQVGDNCREDGNANDTKTTTATGVAADQPSCTSKNSAVASETRECVAISIPQPRSWSSPAQNTSLVLNPIAAEANSRKTTCWNTSSVNDGCEAAGFGDQISLLGKTSSPWETPPSLGESPLAELSQLYLTAGPMCEAPQGETTRSIPLEARNALENFAKAWEPRENVTHLPRESGLEGGSPQKEGKRRQSVGGVWAGIPLSVATDSKGLQLVNHEAASSPNIFNVSEPPTTMSNSGMAEGLEHQTAPSSVEEHHFARLQYPAAQQAQLLMMADGRLAMYPVYSPPYVHQAVVMSPPHGGAAVPHHHVQHQHSLAFYPQVVVPVSQMPSGTWSPYAQSPGVHQ
Protein: Na-K-Cl cotransporter (Q8THK8)
Organism: Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Alpha-amylase family protein
Sequence:
MGGQKNLENEPFEAGEGEPLEAGEDTKSLQEQVEEQKAKPVLFGTFEGVFVPNLLTILGVIMYLREGWVVGNAGLLGAWLIILLSFAITTCTGLSLSSITTNIRIGAGGAFSIISQSLGLEVGGSIGIPLYLSQALAVSMYIFGIRAGWRWFFPEHPALYIDLAAFILLFVIAYISARLAFRIQYFILVVIVASLVSVFWTGFGDSMQGSVQLWGSFPGSPETGFVGIGFWEVFAVYFPAATGIMAGANMSGELKTPRKSIPLGTLSVIGISLCIYLALAYWFALSATPEELVSNYTIIFEKAAFGPIVVAGLLGATFSSALNSIVGAPRILQALGEHGILPKSEWFSQKTDRGEPRNAILFTGTIVLGAIMLRNLNSVAPLITMFFLITYSMINVVVFIEQNLKLVSFRPLFKIPLSVSFLGAAGSLFAMFIINPGFSLLAVVVVLLIHNYLLRKHLKAPFGDVRSGLFVTVAEWAAKKTNSLTSSSERTWKANLLVPVEDPRELMGTFDFLRDITYPKGSVKLLGLAGNTDKENLLSQLPSISEGFQEEGVFSSWTIIDTAEFEENLVVGMEALTGSFFRPSILFLRLPENRDRDEEIREIIRKASMYRMGVLLFSKHPQAGLGRQNLINLWIENRGLDWDISMELGNMDLALLIAYKLKSNWKASLSFMTFAPTAIQAQAAENFLQSLAELARIPNVKMQVLRENPIKSSKLPFASLHIFSLDPNPDLDLARHLMEKAGSSCIFALDSGEENALA
Protein: Large ribosomal subunit protein uL4 (50S ribosomal protein L4) (TmaL4) (P38516)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
Interaction partners:
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS17
Sequence:
MAQVDLLNVKGEKVGTLEISDFVFNIDPNYDVMWRYVDMQLSNRRAGTASTKTRGEVSGGGRKPWPQKHTGRARHGSIRSPIWRHGGVVHGPKPRDWSKKLNKKMKKLALRSALSVKYRENKLLVLDDLKLERPKTKSLKEILQNLQLSDKKTLIVLPWKEEGYMNVKLSGRNLPDVKVIIADNPNNSKNGEKAVRIDGLNVFDMLKYDYLVLTRDMVSKIEEVLGNEAGKALTA
Protein: C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53] (P23582)
Organism: Homo sapiens (Human)
Function: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3.
Subcellular location: Secreted.
Interaction partners:
- Atrial natriuretic peptide receptor 3
- Atrial natriuretic peptide receptor 2
- Natriuretic peptides A
- Atrial natriuretic peptide receptor 1
- Natriuretic peptides B
- Fibroblast growth factor receptor 3
- Osteocrin
Sequence:
MHLSQLLACALLLTLLSLRPSEAKPGAPPKVPRTPPAEELAEPQAAGGGQKKGDKAPGGGGANLKGDRSRLLRDLRVDTKSRAAWARLLQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC
Protein: Nucleolysin TIAR (TIA-1-related protein) (Q01085)
Organism: Homo sapiens (Human)
Function: RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation. Shows a preference for uridine-rich RNAs. Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1. Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:10613902}. Cytoplasm {ECO:0000250|UniProtKB:P70318}. Cytolytic granule {ECO:0000269|PubMed:1326761}. Cytoplasm, Stress granule {ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:18691976}. Note=Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity). Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902}.
Interaction partners:
- Ras GTPase-activating protein-binding protein 1
- Cytotoxic granule associated RNA binding protein TIA1
- ELAV-like protein 1
- Eukaryotic translation initiation factor 4 gamma 1
- Fragile X messenger ribonucleoprotein 1
- TAR DNA-binding protein 43
- Eukaryotic translation initiation factor 3 subunit B
- Caprin-1
- Eukaryotic translation initiation factor 4E
- Heterogeneous nuclear ribonucleoprotein H
Sequence:
MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ
Protein: Agamous-like MADS-box protein AGL21 (Q9SZJ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Tryptophan aminotransferase-related protein 3
- AGAMOUS-like-56
- Transcription factor PRE3
- Probable indole-3-pyruvate monooxygenase YUCCA5
- Small GTPase-like protein LIP2
- At5g26880
Sequence:
MGRGKIVIQRIDDSTSRQVTFSKRRKGLIKKAKELAILCDAEVGLIIFSSTGKLYDFASSSMKSVIDRYNKSKIEQQQLLNPASEVKFWQREAAVLRQELHALQENHRQMMGEQLNGLSVNELNSLENQIEISLRGIRMRKEQLLTQEIQELSQKRNLIHQENLDLSRKVQRIHQENVELYKKAYMANTNGFTHREVAVADDESHTQIRLQLSQPEHSDYDTPPRANE
Protein: Expressed protein (Q9SL96)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT2G45990 protein
- Uncharacterized protein At4g24700
- Protein trichome birefringence-like 12
- Maternal effect embryo arrest 9
- Small ribosomal subunit protein cS23z
- Small ribosomal subunit protein uS3x
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- PHD finger protein ALFIN-LIKE 4
- Auxin-responsive protein SAUR66
Sequence:
MAGGGNRRDEGSITIQSTNLFAALDTRKKKKKSDKAGKSKGSSKSREPEKEPEPQVYWAPTPLKVKSWADIDDEDDDDDYYATTAPPQSGWSTSLPSHTDSKDVHVEESESEEDILDEGDDDVEEEQEQETEVQVHPEPEVKKAPEVPAPPKEAERQLSKKERKKKELAELEALLADFGVAPKENNGLEESQEAGQEKKEDVNGEGEKKENAAGGESKASKKKKKKDKQKEVKESQEQQANNNADAVDEAAGSEPTEEESPIDVKERIKKLASMKKKKSGKEVDAAAKAAAEEAAARRKKLAAAKKKEKNHYNQQPVR
Protein: Twist-related protein (T18) (X-twist) (P13903)
Organism: Xenopus laevis (African clawed frog)
Function: Probable transcription factor, which may be involved, with other proteins, in establishing the pattern of cell type-specific gene expression in mesodermal cell subgroups.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MMQEESSSPVSPVDSLSNSEEELDKQQSKRGCRKRRSARKSPEDPDSPISVKRNKKASSTGSSPQSFEELQSQRVMANVRERQRTQSLNEAFSSLRKIIPTLPSDKLSKIQTLKLASRYIDFLCQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH