wanglab/gogpt-training-data huggingface dataset:
Protein: Plexin-D1 (Q9Y4D7)
Organism: Homo sapiens (Human)
Function: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q3UH93}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q3UH93}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:24841563}.
Interaction partners:
- Semaphorin-3E
- Semaphorin-4A
- Semaphorin-3C
- Neuropilin-1
- Semaphorin-3A
- Neuropilin-2
- Vascular endothelial growth factor receptor 2
- PDZ domain-containing protein GIPC1
- Transmembrane and coiled-coil domains protein 1
- Cilia- and flagella-associated protein 100
Sequence:
MAPRAAGGAPLSARAAAASPPPFQTPPRCPVPLLLLLLLGAARAGALEIQRRFPSPTPTNNFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAPPAEPVTVFPSMLNVAANHPNASTVGLVLPPAAGAGGSRLLVGATYTGYGSSFFPRNRSLEDHRFENTPEIAIRSLDTRGDLAKLFTFDLNPSDDNILKIKQGAKEQHKLGFVSAFLHPSDPPPGAQSYAYLALNSEARAGDKESQARSLLARICLPHGAGGDAKKLTESYIQLGLQCAGGAGRGDLYSRLVSVFPARERLFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFVEPAPDVVAVLDSVVQGTGPACERKLNIQLQPEQLDCGAAHLQHPLSILQPLKATPVFRAPGLTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHVMQFDPADSGYLYLMTSHQMARVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQHFWTSASEGPSRCPAMTVLPSEIDVRQEYPGMILQISGSLPSLSGMEMACDYGNNIRTVARVPGPAFGHQIAYCNLLPRDQFPPFPPNQDHVTVEMSVRVNGRNIVKANFTIYDCSRTAQVYPHTACTSCLSAQWPCFWCSQQHSCVSNQSRCEASPNPTSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAFFQGAALECSFGLEEIFEAVWVNESVVRCDQVVLHTTRKSQVFPLSLQLKGRPARFLDSPEPMTVMVYNCAMGSPDCSQCLGREDLGHLCMWSDGCRLRGPLQPMAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLSGVVTVNASKEGKSRDRFSYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHGNLTFWYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEVAVAEELLDPEEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIHCSVNESLGAAVGQLPITIQVGNFNQTIATLQLGGSETAIIVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHALEQQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLSEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWFASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLIDKKDNTLGRVKDLDTEKYFHLVLPTDELAEPKKSHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARRTQLQHKFEQVVALMEDNIYECYSEA
Protein: Tetratricopeptide repeat protein 21A (TPR repeat protein 21A) (Stress-inducible protein 2) (Q8NDW8)
Organism: Homo sapiens (Human)
Function: Intraflagellar transport (IFT)-associated protein required for spermatogenesis. Required for sperm flagellar formation and intraflagellar transport.
Interaction partners:
- WD repeat-containing protein 19
- Intraflagellar transport protein 140 homolog
- WD repeat-containing protein 35
- Intraflagellar transport protein 20 homolog
- Intraflagellar transport protein 122 homolog
- Cilia- and flagella-associated protein 43
- Intraflagellar transport protein 74 homolog
- Tetratricopeptide repeat protein 29
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 52 homolog
Sequence:
MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLRP
Protein: Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein) (Q9Y314)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. Nucleus {ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
Interaction partners:
- Nitric oxide synthase 3
- U5 small nuclear ribonucleoprotein 40 kDa protein
Sequence:
MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPDDVQPGPSVGPPSKDKDKVLPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGDKLTDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA
Protein: Probable peptide transporter ptr2 (Peptide permease ptr2) (Q9P380)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Uptake of small peptides.
Subcellular location: Membrane {ECO:0000305|PubMed:10759889}; Multi-pass membrane protein {ECO:0000305|PubMed:10759889}.
Interaction partners:
- Uncharacterized oligopeptide transporter C1840.12
- Glutathione transporter 1
- Sexual differentiation process protein isp4
- Uncharacterized protein C11D3.15
- Uncharacterized transporter C11D3.18C
- Putative hydro-lyase C5H10.01
- Uricase
- E3 ubiquitin-protein ligase ubr11
Sequence:
MSSIEEQITKSDSDFIISEDQSYLSKEKKADGSATINTADEQSSTDELQKSMSTGVLVNGDLYPSPTEEELATLPRVCGTIPWKAFIIIIVELCERFAYYGLTVPFQNYMQFGPKDATPGALNLGESGADGLSNFFTFWCYVTPVGAALIADQFLGRYNTIVCSAVIYFIGILILTCTAIPSVIDAGKSMGGFVVSLIIIGLGTGGIKSNVSPLMAEQLPKIPPYVKTKKNGSKVIVDPVVTTSRAYMIFYWSINVGSLSVLATTSLESTKGFVYAYLLPLCVFVIPLIILAVSKRFYKHTPPSGSIFVRVGQVFFLAAQNKFNLEKTKPSCTTTVGRVTLKDQWDDLFIDELKRALRACKTFLFYPIYWVCYGQMTNNLISQAGQMQTGNVSNDLFQAFDSIALIIFIPICDNIIYPLLRKYNIPFKPILRITLGFMFATASMIYAAVLQAKIYQRGPCYANFTDTCVSNDISVWIQIPAYVLIAFSEIFASITGLEFAFTKAPPSMKSIITALFLFTNAFGAILSICISSTAVNPKLTWMYTGIAVTAFIAGIMFWVCFHHYDAMEDEQNQLEFKRNDALTKKDVEKEVHDSYSMADESQYNLEKATAEEEIMKST
Protein: Cholesterol 22-monohydroxylase CYP90B52 (EC 1.14.14.-) (Cytochrome P450 CYP90B52) (PpCYP90B52) (A0A517FNB9)
Organism: Paris polyphylla (Daiswa polyphylla)
Function: Canonical brassinosteroid (BR)-biosynthetic enzyme capable of converting cholesterol to 22S-hydroxycholesterol via sterol-C22 hydroxylation.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEGLLLLLPTAIIALYLYISLIRRSRKKHNLPPGSDGWPFLGETFSYLKPHSAISIGRFMEDHISRYGKIYRSNLFGEPTIVSADAELNRFVLQNEGRLFECSYPRSIGGILGKWSMLVLVGDMHRDMRMISLNFMSAARLRTRLMPEVERQTLLVLRSWREGSTFSAQEEAKKFTFNLMAKHIMSMDPGEPETEMLRREYITFMKGVVSAPLNFPGTPYWKALKSRSSILAVIERKMEERIGRRDRGDGGVEDDDLLGWAMNQSNLLKEQILDLLLSLLFAGHETSSMALALAIYFLESCPEAVRDLRDEHLAISMSGKEGECGLSWDQYKQMEFTHCVINESLRLGNVVRFVHRKAIQDVQYKGYDIPCGWKVLPVFAAVHLDSTLYSDPHRFNPWRWQSSSSKTTAANFMPYGGGLRLCTGSELAKLEMAVFLHHLVLNYQWKLAEPEQAFAYPFLDFPKGLQIKVRAIT
Protein: Mediator of RNA polymerase II transcription subunit 18 (Q9SJZ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Involved in the regulation of histone H3 lysine tri-methylation (H3K36me3). Associates with the promoter, coding and terminator regions of target genes suggesting its function in transcription initiation, elongation and termination. Multifunctional protein which regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea and A.brassicicola), flowering time and responses to hormones (e.g. abscisic acid ABA and ethylene) through interactions with distinct transcription factors.
Subcellular location: Nucleus {ECO:0000269|PubMed:24451981}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 22b
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 22a
- Cyclin-dependent kinase E-1
- Mediator of RNA polymerase II transcription subunit 7a
- Mediator of RNA polymerase II transcription subunit 10b
Sequence:
MSMECVVQGIIETQHVEALEILLQGLCGVQRERLRVHELCLRSGPNLGVVSSEVRLLCDLDQPEPTWTVKHVGGAMRGAGADQISVLVRNMIESKVSKNALRMFYALGYKLDHELLKVGFAFHFQRTAHISVSVSSVNKMPKVHAIDEAVPVTPGMQIVDVTAPATSENYSEVAAAVSSFCEFLAPLVHLSKPSISTGVVPTAAAAAASLMSDGGGTTL
Protein: Proteinase inhibitor CeKI (P84795)
Organism: Paubrasilia echinata (Pau Brasil) (Caesalpinia echinata)
Function: Potent inhibitor of serine proteases plasma kallikrein, plasmin and coagulation factor XIIa. Weak inhibitor of serine proteases trypsin and coagulation factor Xa. Does not inhibit the serine proteases chymotrypsin, elastase or thrombin. Inhibits kinin release from HMW-kininogen by kallikrein in vitro.
Interaction partners:
Sequence:
FVVETENQLMSQGGRYYILPVIYGKGGGLG
Protein: Aldehyde-alcohol dehydrogenase (Q6Q3I2)
Organism: Listeria monocytogenes
Interaction partners:
Sequence:
MAIKENAAQEVLEVQKVIDRLADNGQKALKAFESYNQEQVDNIVHAMALAGLDQHMPLAKLAVEETGRGLYEDKCIKNIFATEYIWNNIKNNKTVGVINEDVQTGVIEIAEPVGVVAGVTPVTNPTSTTLFKAIIAIKTRNPIIFAFHPSAQRCSSAAAKVVYDAAIAAGAPEHCIQWVEKPSLEATKQLMNHDKVALVLATGGAGMVKSAYSTGKPALGVGPGNVPAYIDKTAKIKRSVNDIILSKSFDQGMICASEQAVIVDKEVAKEVKAEMEANKCYFVKGAEFKKLESYVINPEKGTLNPDVVGKSPAWIANQAGFKVPEDTKILVAEIKGVGDKYPLSHEKLSPVLAFIEAANQAEAFDRCEEMLVYGGLGHSAVIHSTDKEVQKAFGIRMKACRIIVNAPSAQGGIGDIYNGFIPSLTLGCGSYGKNSVSQNVSATNLLNVKRIADRRNNMQWFKLPPKIFFEKYSTQYLQKMEGVERVFIVTDPGMGSFKYVDVVIEHLKKRGNDVAYQVFADVEPDPSDVTVYKGAELMKDFKPDTIIALGGGSAMDAAKGMWLFYEHPEASFFGLKQKFLDIRKRTFKYPKLGGKAKFVAIPTTSGTGSEVTPFAVITDKENNIKYPLADYELTPDVAIVDAQYVTTVPAHITADTGMDVLTHAIESYVSVMASDYTRGLSIRAIELVFENLRESVLTGDPDAREKMHNASALAGMAFANAFLGINHSLAHKIGPEFHIPHGRANAILMPHVIRYNALKPKKHALFPRYESFRADEDYARISRIIGFPAATTEEGVKSLVDEIIKLGKDVGIDMSLKGQNVAKKDLDAVVDTLADRAFMDQCTTANPKQPLVSELKEIYLEAYKGV
Protein: C-X-C chemokine receptor type 3-2 (E9QJ73)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for the C-X-C chemokines cxcl11.1 and cxcl11.6. Promotes macrophage chemotaxis to sites of bacterial infection.
Subcellular location: Cell membrane {ECO:0000305|PubMed:25573892}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- C-X-C motif chemokine 11-1
- C-X-C motif chemokine
- Chemokine
- Chemokine
- Chemokine
- C-X-C chemokine receptor type 3
- Growth-regulated alpha protein-like
- Macrophage-expressed 1, tandem duplicate 1.
- Tyrosine-protein phosphatase non-receptor type
Sequence:
MDNSTTAAEVSAPTDYDYNSTSYDDDNPYAAPCSLTETWNFLGRFAPVAYILVFILALVGNILVLCVIRRYRQSRHSPCSFSLTDTFLLHLAVSDLLLAATLPFFAVEWISEWVFGKVMCKITGALFSLNVYCGVLFLACISFDRYLAIVHAINISWRRKTCHAQLACAFIWVICLGLSMVDMHFRDLVEIPGMNRMVCQIVYSEQYSKQWQIGMQLVSMVLGFILPLLVMLYCYLHIFKALCHATRRQKRRSLRLIISLVIVFVISWAPYNALRMTDSLQMLGVIVKSCALNNVLDVGILVTESLGLAHCALNPLLYGLVGVKFRRELAQMCKAALGPQGCLGLVGWANGRGSSTRRPTGSFSSVETENTSYFSVMA
Protein: SNARE complex subunit (Tlg2), putative (Eurofung) (C8VLM4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Interaction partners:
- Vesicle transport v-SNARE protein vti1
- Synaptobrevin homologue SNC1/2
- Vacuolar protein sorting-associated protein 45
- Uncharacterized protein
- Vesicular-fusion protein sec17
- SNARE complex subunit
- Synaptobrevin homolog YKT6
- ER-Golgi SNARE complex subunit Sed5
- Protein transport protein SEC9
- GARP complex subunit Vps53, putative
Sequence:
MWRDRTNLYISYRQSFTHHPAKKPRYLGTPNGFSDVASQSEESRRLISESTGIDDDGDAIIEMDVLPPRWVDVQEDVTDLLADIAQKSAQLDKLHHKHLLPGFGDEEVRKQDERVIERYTQEITRGFHECQKLVKRIEVMVHEAKQQGGVSSGDETMAKNIQISLASRVQEASAQFRKKQSNYLKKLRGLEDTASQFDRSTTPMQNPYTDPSLMESDADKSFSQTTLMQTTQRMTGQNDAAILQREREINDIAKGIIELSDIFRELQAMVIDQGTMLDRIDYNVERMNTDVQAAQKELNVATNYQRRTTKRKIILLLILLVVGMIIILLVKPKKHESSEPAPPPTQPENLPPGLRPRGFEIAYRRPRSPSLTRVARSEWVDPDIYR
Protein: Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) (P26883)
Organism: Mus musculus (Mouse)
Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62942}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P62943}; Peripheral membrane protein {ECO:0000250|UniProtKB:P62943}; Cytoplasmic side {ECO:0000250|UniProtKB:P62943}.
Interaction partners:
- Ryanodine receptor 1
- Serine/threonine-protein kinase mTOR
- Regulatory-associated protein of mTOR
- Activin receptor type-1
- Ryanodine receptor 2
- Calmodulin-1
- TGF-beta receptor type-1
- Calmodulin-4
- Calmodulin 5
- Calmodulin-like protein 3
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFTLGKQEVIRGWEEGVAQMSVGQRAKLIISSDYAYGATGHPGIIPPHATLVFDVELLKLE
Protein: Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) (P21396)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:15050826}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15050826}; Cytoplasmic side {ECO:0000269|PubMed:15050826}.
Interaction partners:
- Catechol O-methyltransferase
- Transmembrane O-methyltransferase homolog
- Aromatic-L-amino-acid decarboxylase
- Aldehyde dehydrogenase
- Amine oxidase [copper-containing] 3
- Dopamine beta-hydroxylase
- Amine oxidase
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Amine oxidase
- Diamine oxidase [copper-containing]
Sequence:
MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
Protein: RNA-binding motif protein, Y chromosome, family 1 member B (A6NDE4)
Organism: Homo sapiens (Human)
Function: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
Subcellular location: Nucleus.
Interaction partners:
- RNA-binding motif protein, Y chromosome, family 1 member A1
- RNA-binding motif protein, Y chromosome, family 1 member E
- RNA-binding motif protein, Y chromosome, family 1 member D
- Testis-specific Y-encoded protein 4
- Testis specific protein Y-linked 4
- Testis specific protein Y-linked 2
Sequence:
MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREAYGSSSYVASIVDGGESRSEKGDSSRY
Protein: Uncharacterized protein (A0A1D8PGU5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MFFLIQLQPSKTYIQIMLRPIRWNPRMVGIRSFSITRLNFNTNNNTRASPSSSSLFAYIHDYNTLLEKVKSTITSNSSESDILEAMNGIKNLQNNYPIQDQINDTSKLTKQSISIINTIFKNDDDRKFSSKLLHDILILNLPSSLNIKVIKHYYKSNPTDVISKEVALIPLRNAIFNAEFMKAIKLTDLTVGHENYINHMNQILKSGVIKLISTAIIVTLFTKLGVSSLIDAGVISQSWQSIGAINSIILTYLINSSFFISIVKLGRTLINAGGDYLTWQKGTFYTHWFKHADEMLFSSKIIEADRELNQGESNPDIIEELCRRPPDDRDSMRGLKPGVDRDGNKIRLLQLKDDLNKVTFQAYWMTGGDGFEWIEPDQDPADIQWRKHLELYNKPALKQGEFGALGWADDLIQKSTKDV
Protein: Large ribosomal subunit protein uL6 (60S ribosomal protein L9) (Q95Y90)
Organism: Caenorhabditis elegans
Interaction partners:
- Ubiquitin-like domain-containing protein
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein uL30
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS19
- Mitochondrial Ribosomal Protein, Large
- Small ribosomal subunit protein eS12
Sequence:
MKLIESNDTVVFPEGVTFTVKNRIVHVTGPRGTIRKDFRHLHMEMERIGKSTLRVRKWFGVRKELAAIRTVCSHIKNMIKGVTVGFRYKMRSVYAHFPINVTLQDGNRTVEIRNFLGEKIVRRVPLPEGVIATISTAQKDEIVVEGNDVQFVSQAAARIQQSTAVKEKDIRKFLDGIYVSEKTTIVPTD
Protein: Receptor expression-enhancing protein (Q7JRH2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU362006}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362006}.
Interaction partners:
Sequence:
MISSLFSRLIILFCGTLYPAYASYKAVRTKDVKEYVKWMMYWIVFAFFTCIETFTDIFISWLPFYYEVKVALVFWLLSPATKGSSTLYRKFVHPMLTRHEQEIDEYVNQAKERGYSAVLQLGSKGVNYATNVLMQTAIKTYALTTAPSGHGRGLQNSHSADELYRGQDTMDSTENWLPRASSLSSIESYTETIYEPRTETKRLVIREVSEEAEFDDDPLGDAGAARLRDMPVRKAQPRRAASTAKAAGKRGQKHNDIEGARSSSSSSNVIRSRRKLREPTPDVDVENY
Protein: Protein STAY-GREEN, chloroplastic (Protein STAYGREEN) (A7VLV1)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Probably involved in the disassembling mechanism of the intact light-harvesting complex of photosystem II (LHCII) in the thylakoid membranes. Required for the chlorophyll breakdown pathway. Acts independent and upstream of pheophorbide a oxygenase (PAO).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:17709752}.
Interaction partners:
Sequence:
MDTLTSAPLLTTKFKPSFSPQQKPCFPHRRRFENGKKNQSIVPVARLFGPAIFEASKLKVLFLGIDENKHPGNLPRTYTLTHSDVTSKLTLAISQTINNSQLQGWYNRLQRDEVVAQWKKVKGKMSLHVHCHISGGHFLLDIFARLRYFIFCKELPVVLKAFVHGDGNLFNNYPELEESLVWVFFHSKIREFNKVECWGPLKEASQPTSGTHSDLKLPQSCEEDCECCFPPLNLSPIPCSNEVINNTYEPIDGIGTQHGNL
Protein: p-glycoprotein/multidrug resistance protein (Q24393)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MIGVRTLYYYCSEPNKSKKKSKHDESDASDEEDGSEYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVGTGLTTPANSLIFGNLANDMIDLSGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGMIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFFIYASYALAFWYGVGLVIESAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAQGRLPKVFHIIEQIPEINPLMGRVKVNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRFLRIGVVGQEPILFATSIYENIRYGREDATREEIEAARAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIRRALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKMKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIIQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMRPAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQAVIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQSGSM
Protein: Nodal homolog (Q96S42)
Organism: Homo sapiens (Human)
Function: Essential for mesoderm formation and axial patterning during embryonic development.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Activin receptor type-2B
- Left-right determination factor 2
- Left-right determination factor 1
- Protein Cripto
- Activin receptor type-2A
- Activin receptor type-1C
- Cryptic protein
- Cerberus
- Activin receptor type-1B
- Zinc finger protein ZIC 3
Sequence:
MHAHCLPFLLHAWWALLQAGAATVATALLRTRGQPSSPSPLAYMLSLYRDPLPRADIIRSLQAEDVAVDGQNWTFAFDFSFLSQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPDTEQASDSCLERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWLKHPGALEKQMSRVAGECWPRPPTPPATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKRHRRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHKDMIVEECGCL