wanglab/gogpt-training-data huggingface dataset:
Protein: Nucleosome-remodeling factor subunit NURF301-like (Q6BER5)
Organism: Caenorhabditis elegans
Function: Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063}.
Interaction partners:
- Dosage compensation protein dpy-30
- Retinoblastoma-binding protein homolog 5
- Set1/Ash2 histone methyltransferase complex subunit ash-2
- Chromatin-remodeling complex ATPase chain isw-1
- Histone-lysine N-methyltransferase set-2
- RING-type E3 ubiquitin transferase
- Histone H3.3 type 1
- Histone H3-like centromeric protein cpar-1
- Histone H3.3-like type 1
- Histone H3.3-like type 2
Sequence:
MAPPRGRSKRKHPSESGNSSIADSEDPSESTSSSRPRRSRLPKRYFDDGYSPPPTKKRAAQRETPSDAEEVEVKIEEISVRSTPASTPAPKSTSKARGRPKKNPTPPRRKSLKRQEEDIIYMDEDSEEEEESSDDEFMLNEDQVVQEEEEELNLTDIKIEKGLDEENKYCPWLDEDPASLPKLELPESSQDIPIPTASIMDAVEIYEILRSYHRTLRITPFTFEDFCAALISHNNSCIMAEVHMALLRNCLKSDDEEQTHYSVTETNNSVNIMIHHMDTLTYAEILRQYIEAYPFADASVRDAINVDNYPFVGYDAKLVVLLFMSYRFLYSSEFKKLVNNVGKFQNDENCRVCGKSSGRVVGCTQCEAAFHVECSHLKPFPEVLVCNICKKNSAVRGVLPPDEAVDREPLRSQPIGRDRYGRYYWFIVRRLVVQSLDETELYYYSTVPQLYQLLQKLDRTYYEKDLCDTIRLRIDEFLEQMALTVEMTSERREAALETMVKRQLIGYDFAEATTPQIYLHRDSMKRMASILRDCAQKGQVKQEVKLEEPVEGQSPVKCVQFVEDSILPESMIGIFDAKLINTFWSGGATQEELVEQFVDISDNFDAPSANLWRMGDEGNDQTFMTYYNYYSRNEMSESFLTRKKAADKKKYMASKFAQIDNFDWVVAKNRQFYGDASLHCKFIMWTLQQVIKNIPIDLMHRKWPEFAKGFDLEVSVADDYKKLVTCLLKLDCAVRKTIFMPQWWNGLGQTRLERITVDQRENFMKEQQRLKKIDADALTKDLDDSFVRVNYMKPKWPNTYILRQRGETYRNAGKGSMGGWAWVAAKYVEKWIQVPESPKLPLAVTVEEIKTESVSNRKARRLELLVSKITKKRQRSGGKSSKKPTFELTNGCYSPSCRSNPNRKCYSPMCRNGYLVSAKQAHDERKLEESGVLGEEKAWPIPEIQTFSTKRGGKSIFVLQKKILRQMIMGGGCQQVYMPGFSAGIKSNLLIWPYPAPRPTLDLCWKWQTLNARSLHAVALQLKIIWSSIKFNEFDPDDTHPDRRVVIDTPSHDERRRIIRHKEMPPYGQYERYEMEIEIIPLYDEPEEEDESWLSRNRGGSSEFSHRSSSARKKRPQRSLDNRRATAIRREWVDGVTLKVFEIKDYWKWIRAEAEKTAKRKLEATRKAQKAKEDEERRRIQQQQQRSVARIPVPMHSLIPSERNNVPYLGSQQQRRPNGNERGFLEKYNNSSSVSPQAHGYASTPPPGYHQPQPNIIRQAGYNQLPRKPTTSPFNFQSRPVATIPTTPQLRAAAGADGVVRAVMMTPGNKSTVNTNSTPYPQALNRQQYQLQRQQQQPAVRRLTNGYHFMDGTMRGGGRNPSVQMHQRLPQNRAALQRPFGESTTEMRRVTEAAIPDNDGDEQPPVIPRYDPTSNFDAQRAQQQHPQSRPVYSTPAQMIRTTQPGGVKHNVILMKASDGTQKMVLKPGQFPPGTVISTGQRVVPYRQPTAVQQRQLYTATPGTRVVRIPNANGGAPRQQDHQVMRRVVQASGPRAMEYMDDQGTPPPGQQVRYVLQGGNSGTPNVNPPKVSSRGGPRGGLTMQMVQQQQQHNPEHRRLLAGRQKQKVTTYRDFMASRGYLDTSKFMMQTKPTFLPFEFNEEEEREINEAIAREEAWMRQEEENKTSGYDSSGNPIRSITSSGDTQRAPPYVSNLLPSSNDSPDDKVIKQVLDVMFSQVCRWDRQYGWSKTHVKRARQKNDSDKMHLRKFRMNQRELLITDHMERLKKEINKRRTRMENEAEQQCGLLTPWRKARARPHRAAKPKAEVKKEVINPADITLGGDTYDYVKEQKPTESIATNVSRRRRTSANLSKSEDDRDKPESQSTAPKSKERRTSEPPASHVAFHTPGSATPHDINLSIEHCTCQKIFDASKLYIQCELCARWYHGDCVGVAEQTILGLEHWSCEECIEEQERVKDQPALYCVCQKPYDDTKFYVGCDSCQGWFHPECVGTTRAEAEQAADYNCPACTREAEGYESEASDVSGSSRVSVQLTRADYTHVFELLELLLEHRMSTPFRNPVDLNEFPDYEKFIKKPMDLSTITKKVERTEYLYLSQFVNDVNQMFENAKTYNPKGNAVFKCAETMQEVFDKKLIDVREQMTARQQMLLLATAQQQDPMSSIRKRVQSESQRTVDSLDIDSDQLLPLDANLMRLYDF
Protein: Splicing factor 3B subunit 6-like protein (Pre-mRNA branch site p14-like protein) (O59670)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Necessary for the splicing of pre-mRNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Uncharacterized protein C211.05
- Pre-mRNA-splicing factor ini1
- Pre-mRNA-splicing factor prp12
- U2 snRNP component prp10
- Uncharacterized protein C1782.03
- Pre-mRNA-splicing factor sap62
- Pre-mRNA-splicing factor prp1
- Pre-mRNA-splicing factor dre4
- Spliceosome-associated protein 49
- Pre-mRNA-splicing factor sap145
Sequence:
MPPSTVNQEVNSILFIKNLSFKITAEEMYDLFGRYGPVRQIRLGNTVQTRGTAFVVYENVQDARRACEKLSGYNFMDRYLVVHYYNPERAKVDGQDLAARYAALEQVKQKYGVQL
Protein: Dynamin 2 (K7ENE7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPR
Protein: Ufm1-specific protease 1 (UfSP1) (EC 3.4.22.-) (Q9CZP0)
Organism: Mus musculus (Mouse)
Function: Thiol-dependent isopeptidase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6NVU6}.
Interaction partners:
- Ubiquitin-fold modifier 1
- Ubiquitin-fold modifier-conjugating enzyme 1
- Ubiquitin-like modifier-activating enzyme 5
- E3 UFM1-protein ligase 1
- DDRGK domain-containing protein 1
Sequence:
MTAALPSTLELLKDVHLGLPVPCHDPARLALLSGHYLYYHYGCDGLDDRGWGCGYRTLQTLCSWPGGQSSGVPGLPALQGALEAMGDKPPGFRGSRNWIGCVEASLCLEHFGGPQGRLCHLPRGVGLRGEEERLYSHFTTGGGPVMVGGDADAQSKALLGICEGPGSEVYVLILDPHYWGTPKNRCELQAAGWVGWQKVKSVFDSNSFYNLCFTRNL
Protein: Quorum sensing transcriptional regulator LitR (HapR) (Q5E2S4)
Organism: Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Interaction partners:
- Autoinducer repressor protein LuxO
- Autoinducer phosphorelay protein LuxU
- histidine kinase
- acyl-homoserine-lactone synthase
- Transcriptional activator protein LuxR
- S-ribosylhomocysteine lyase
- Autoinducer 2-binding periplasmic protein LuxP
Sequence:
MDTIQKRPRTRLSPEKRKEQLLDIAIEVFSQRGIGRGGHADIAEIAQVSVATVFNYFPTREDLVDDVLNKVENEFHQFINNSISLDLDVRSNLNTLLLNIIDSVQTGNKWIKVWFEWSTSTRDEVWPLFLSTHSNTNQVIKTMFEEGIERNEVCNDHTPENLTKMLHGICYSVFIQANRNSSSEEMEETANCFLNMLCIYK
Protein: Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) (P50753)
Organism: Rattus norvegicus (Rat)
Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Interaction partners:
- Troponin I, cardiac muscle
- Troponin C, slow skeletal and cardiac muscles
- Troponin I, slow skeletal muscle
- Tropomyosin alpha-1 chain
- Troponin I, fast skeletal muscle
- Actin, alpha cardiac muscle 1
- Tropomyosin beta chain
- Tropomyosin 3
- Tropomyosin alpha-4 chain
- Troponin C, skeletal muscle
Sequence:
MSDAEEEVVEYEEEQEEEDWSEEEEDEQEEAVEEEDGEAEPDPEGEAEAEEDKAEEVGPDEEARDAEDGPVEDSKPKPSRLFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQTLIEAHFENRKKEEEELISLKDRIEKRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIHNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Protein: Vesicle-associated membrane protein 721 (AtVAMP721) (v-SNARE synaptobrevin 7B) (AtVAMP7B) (Q9ZTW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q12255}. Early endosome membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q12255}.
Interaction partners:
- SNAP25 homologous protein SNAP33
- Arabidiol synthase
- Syntaxin-121
- Syntaxin-132
- Syntaxin-122
- Syntaxin-71
- Putative syntaxin-24
- Novel plant SNARE 11
- Potassium channel KAT3
- Syntaxin-related protein KNOLLE
Sequence:
MAQQSLIYSFVARGTVILVEFTDFKGNFTSIAAQCLQKLPSSNNKFTYNCDGHTFNYLVEDGFTYCVVAVDSAGRQIPMSFLERVKEDFNKRYGGGKAATAQANSLNKEFGSKLKEHMQYCMDHPDEISKLAKVKAQVSEVKGVMMENIEKVLDRGEKIELLVDKTENLRSQAQDFRTTGTQMRRKMWLQNMKIKLIVLAIIIALILIIVLSVCHGFKC
Protein: Regulatory protein zeste (P09956)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.
Subcellular location: Nucleus.
Interaction partners:
- Adenosine kinase
- IP10578p
- Thioredoxin-T
- Dorsal interacting protein 4
- Probable ATP-dependent RNA helicase DDX46
- Microfibrillar-associated protein 1
- Splicing factor 3B subunit 1
- Pre-mRNA-splicing factor 38
- Splicing factor 3B subunit 4
- Probable U2 small nuclear ribonucleoprotein A'
Sequence:
MSAQGEGGGAGGSGGGGAGSDGGGNAGQSSTGSGTVAVTNGGNSSAKNQLPLTPRFTAEEKEVLYTLFHLHEEVIDIKHRKKQRNKYSVRETWDKIVKDFNSHPHVSAMRNIKQIQKFWLNSRLRKQYPYRDGSSSNLSSGSAKISSVSVSVASAVPQQQQQQHHQQHDSVKVEPEYQISPDASEHNPQADTFDEIEMDANDVSEIDEDPMEQQQQQQQEAQAQAQAQAQAQAQVQSAAAEMQKMQQVNAVAAAAAANATMINTHQINVDQISAEKLTLNDLLHFKTARPREEIILIKHPEATATQIHTIPTQAQQHPMATITAGGYNQQIISEIKPQQITLAQYQAQQQQQAQAQAQAQAQAQAQAQAQAQAQAQAQQLAQQQLAAAQHQQLAAAVQVHHQQQQQQQAAVAVQQQQAAAAAAVKMQLTAATPTFTFSALPTVTAATTVPAAVPVPVATASSGSANSVAVNTSTASSVSINNTSLGGGGGNGATNSSATAADSFEERMNYFKIREAELRCKEQQLATEAKRIELNKAQDELKYMKEVHRLRVEELTMKIRILQKEEEQLRKCSTS
Protein: Charged multivesicular body protein 2a (Q9U2F6)
Organism: Caenorhabditis elegans
Interaction partners:
- Charged multivesicular body protein 1b
- Charged multivesicular body protein 6
- Charged multivesicular body protein 3
- Charged multivesicular body protein 5
- Vacuolar protein-sorting-associated protein 25
- vesicle-fusing ATPase
- Charged multivesicular body protein 4b
- Vacuolar protein-sorting-associated protein 36
- Vacuolar protein sorting-associated protein 28 homolog
- Charged multivesicular body protein 7
Sequence:
MDFLFGRRKTPAELLRQNQRALNKAIRELDRERARMEAQEKKVIADIKNMAKKNQMDSVKVMAKDLVRTRRYIKKFIVMKANIQAVSLKVQTLKSQDAMASAMKGVTKAMQSMNRQLNLPQIQKIMMEFEKQSEIMDMKEEVMGDAIDDALGDAGDEEETDQIVNQVLDELGIQMGEEMAGLPSAAGGLNAGGERIGGRQAVAAGGSGGAHHGAGGAGGGNDVDDDLQARLDQLRRE
Protein: Oxidoreductase, short-chain dehydrogenase/reductase family (P95101)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAAQGAELYLTDRDRDGLAQTVCDARALGAQVPEHRVLDVSDYQDVAAFAADIHARHPSMDVVLNIAGVSAWGTVDQLTHDQWSRMVAINLMGPIHVIETLVPPMVAAGRGGHLVNVSSAAGLVGLPWHAAYSASKYGLRGLSEVLRFDLARHGIGVSVVVPGAVKTPLVNTVEIAGVDRDDPRVNRWVERFSGHAVTPEKAADKILAGVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRVNVFFTRALRPGP
Protein: Glutathione S-transferase omega (GSTO) (EC 1.20.4.2) (EC 1.8.5.1) (EC 2.5.1.18) (Glutathione-dependent dehydroascorbate reductase) (Monomethylarsonic acid reductase) (Q5U3M8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MASSPKCLGKECSAPGPVPNGQIRLYSMRFCPFAQRTRLVLTAKGVKHDIININLVSKPDWFLKKNPFGTVPVLETSSGQVIYESPITCEYLDEVYPEKKLLPSDPFERAQQKMLLELYSKVIPYFYKISMGKKRGEDVSTAEAEFTEKLLQLNEALANKKTKYFGGDSITMIDYLIWPWFERAEMMGVKHCLAKTPELRKWIELMFEDPVVKATMFNTDVHKVFFDSYMDGKPNYDYGL
Protein: Transmembrane Fragile-X-F-associated protein (F4HS21)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g25682
- Mental retardation GTPase activating protein
- Mental retardation GTPase activating protein
- Protein BYPASS1-LIKE
- Probable galacturonosyltransferase-like 3
- Cyclin-B1-5
- Histone acetyltransferase HAC2
- BRAP2 RING ZnF UBP domain-containing protein 1
- ATP phosphoribosyltransferase 1, chloroplastic
- Acclimation of photosynthesis to environment
Sequence:
MNCWRVLKSVQASVAHCFLFSFTLALVLKLDHSITYSWWVVCLPLWAFHAVVARGRFSLPAPIAPRNRHWAPCHAIVSTPLLIAFELLLCVYLETAYADSPPAVSLKIVFLPLLAFEVIILVDNARMCRALMPGDEESVNDEAVWEALPHFWVAISMVFFLAATVFTLLKLSGDVAALGWWDLFINFGIAECFAFLVCTKWSNPVIHRSSRDRETGSSSTNIRYLDWNSGLGVFSEDDRNQDTCGLQDIGGHIMKIPLIVFQVVLCMHLEGTPEAAKSISVPVLFSPLFLLQGVGVLFAASKLIEKVVLLLRGEDDTGLYFRFLSRAHDCLGFLHHGSRLLGWWSIDEGSREEEARLYFDQESGYNTFCGHPPEIVKKMPKKELAEEVWRLQAALGEQTEITKFSQQEYERLQNEKVLCRVCFEREISVVLLPCRHRVLCRNCSDKCKKCPFCRITIEERLPVYDV
Protein: AP2-like ethylene-responsive transcription factor AIL7 (Protein AINTEGUMENTA-LIKE 7) (Protein PLETHORA 7) (Q6J9N8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable polyol transporter 3
- Agamous-like MADS-box protein AGL93
- Polyol transporter 5
- Protein TIME FOR COFFEE
- TIC-like protein
- Probable polyol transporter 4
Sequence:
MAPPMTNCLTFSLSPMEMLKSTDQSHFSSSYDDSSTPYLIDNFYAFKEEAEIEAAAASMADSTTLSTFFDHSQTQIPKLEDFLGDSFVRYSDNQTETQDSSSLTPFYDPRHRTVAEGVTGFFSDHHQPDFKTINSGPEIFDDSTTSNIGGTHLSSHVVESSTTAKLGFNGDCTTTGGVLSLGVNNTSDQPLSCNNGERGGNSNKKKTVSKKETSDDSKKKIVETLGQRTSIYRGVTRHRWTGRYEAHLWDNSCRREGQARKGRQVYLGGYDKEDRAARAYDLAALKYWGSTATTNFPVSSYSKELEEMNHMTKQEFIASLRRKSSGFSRGASIYRGVTRHHQQGRWQARIGRVAGNKDLYLGTFATEEEAAEAYDIAAIKFRGINAVTNFEMNRYDIEAVMNSSLPVGGAAAKRHKLKLALESPSSSSSDHNLQQQQLLPSSSPSDQNPNSIPCGIPFEPSVLYYHQNFFQHYPLVSDSTIQAPMNQAEFFLWPNQSY
Protein: RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) (Q7TSG2)
Organism: Mus musculus (Mouse)
Function: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively. {ECO:0000250}.
Interaction partners:
- General transcription factor IIF subunit 1
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB7
- General transcription factor IIF subunit 2
- Transcription elongation factor SPT5
- Transcription elongation factor SPT6
- DNA-directed RNA polymerase II subunit RPB4
- Protein IWS1 homolog
Sequence:
MEAPPAAGVPTECTPAVAGAEVRCPGPTPLRLLEWKVAAGATVRIGSVLAVCETAASAQPAGPAPARAASGGCVRAARTERRLRSERAGVVRELCAQPGQVVAPGALLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGRQQVPLSTATVSMVHSVPELMVSSEQAEKLGREDQQRLHRNRKLVLMVDLDQTLIHTTEQHCPQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFPGTGDVNAPPAARETQARRKVNHSSKGGDALEQALSVRDPEDGRPAPGVEHSNGLGKASRELNGGEAVPGVFPSKADEKEAWPLTRASPASSSSGHEPTEAPELPVSCEWDGRTTPGVQPTQGDAATQDLDFDLSSDSESSESSSRSEGQRAPAPQERTKAAPEHSGPQDTSGGRAAASPLGESGPSIHPHDKGSDLDTQEEGERDSLCGLGNGSVDRKEAETESQNSEQSGVTAGESLDQSVGEEEEEDTDDDDHLIHLEEILVRVHTDYYTKYDRYLNKELEEAPDIRKIVPELKSKVLADVAVIFSGLHPTNFPVEKTREHYHATALGAKVLTQLVLSPDAPDRATHLIAARAGTEKVRQAQECKHLHVVSPDWLWSCLERWDKVEEQLFPLIDDDTRTHRDNSPAVFPDRHSVLPTALFHPTPIHSKAHPGPEVRIYDSNTGKLIRMGPQGSAPAPSSAPLNHGEPSSFRAVQPHQQQMFGEELPESQDGEQPGPARRKRQPSMSEAMPLYTLCKEDLESMDKEVDDILGEGSDDSDIEKKKPEDQDNEQERAPKPRKPRAPGIRREQPVGLPSSGERSTPGMRGPRGHKRKLNEEDAASESSGESSNDDEEGSSSEADEMAAALEAELNDLM
Protein: Moesin/ezrin/radixin homolog 2 (Ezrin-moesin-radixin 2) (Merlin) (dMerlin) (Q24564)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway.
Subcellular location: Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Apical cell membrane. Cell projection, rhabdomere {ECO:0000269|PubMed:8666669}. Note=Membrane-associated, adherens junctions and endocytic compartments. Cytoplasmic, punctate.
Interaction partners:
- Protein kibra
- Scaffold protein salvador
- Protein expanded
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase Warts
- GH04176p
- non-specific serine/threonine protein kinase
- Cdc42 homolog
Sequence:
MSPFGSKKNRSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKIAQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFIREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL
Protein: Anthranilate synthase beta subunit 2, chloroplastic (OsASB2) (EC 4.1.3.27) (Anthranilate synthase, glutamine amidotransferase component 2-2) (Q764B9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Anthranilate synthase alpha subunit 1, chloroplastic
- Anthranilate synthase alpha subunit 2, chloroplastic
- Os02g0581500 protein
- anthranilate phosphoribosyltransferase
- Os02g0581400 protein
- Os09g0361500 protein
- Probable aminodeoxychorismate synthase, chloroplastic
- phosphoribosylanthranilate isomerase
- Anthranilate synthase beta subunit 1, chloroplastic
- indole-3-glycerol-phosphate synthase
Sequence:
MATAARLLPKIQSPASPAVAEARRRRPSSLRLGVTSGPARTLKQKLVAKSAVSVVEGENAFDGVKQDTRPIIVIDNYDSFTYNLCQYMGEVGANFEVYRNDDITVEEIKKISPRGILISPGPGTPQDSGISLQTVQDLGPSTPLFGVCMGLQCIGEAFGGKVVRSPYGVVHGKGSLVHYEEKLDGTLFSGLPNPFQAGRYHSLVIEKDSFPHDALEITAWTDDGLIMAARHRKYKHIQGVQFHPESIITTEGRLMVKNFIKIIEGYEALNCLP
Protein: Coiled-coil-helix-coiled-coil-helix domain containing 3 (C9JRZ6)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00034476}; Lipid-anchor {ECO:0000256|ARBA:ARBA00034476}.
Interaction partners:
Sequence:
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKAKHLDIEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
Protein: Chaperonin HSP60, mitochondrial (Protein Cpn60) (Heat shock protein 60) (groEL protein) (Q37683)
Organism: Trypanosoma brucei brucei
Function: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Interaction partners:
Sequence:
MFRCVVRFGAKDIRFGTEARQSMLKGVQRAVEAVATTLGPKGRNVIIEQSYGAPKITKDGVTVAKSIEFKDPFENMGAQLVRQVCNKTNDLAGDGTTTSAVLVASIFSEGIKSIATGTNPIDMKRGMDRAVEVILKNIESQSRTVTNTENVVQVATISANGDVELGKLIGEAMEKVGKDGVITTQDGKTLTTELEVVEGMSVDRGYISPYFVTDAKTQKAELEDAFVLVSAKKLNNIHTILPVLNHVVRSGRPLLIIADDVESEALTTMIFNKLQGKLKIACVKAPGFGDNKAAMLQDIAIFSGACVVGEEGSGVELDAEKFEASILGSVKKATITKDDTVLLNGGGDVAMMKERVDLVRGLIERETSDYNREKLQERLAKLSGGVAVIRVGGASEVEVNEKKDRITDALCSTRAAVQEGIVPGGGPALLRASKALDGLLQDQSLTADQRTGVQIIRNAVRLPAHRIVANAGREGAVVVEKVLENTDAAVGYDAQLDRYVNMFEAGIIDPARVVRVALTDAASVASLMMTAEAAVVDLPKDDAPAAGGMGGMGGMGGMDGMY
Protein: Tubulin alpha 1a (F8W0F6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIGELTSVTQVRSQGAGTGGLSWGAPLVTHPLSLPAPRPSSSSPLLLPHHVLQMKFALAPTASSSTLSNLSQAKKMLPITMPEGTTPLARRSLTSCWTEFASWPTSARVSRASWFSTALVGELVLGSPRCSWNVSQLIMARSPSWSSLFTRRPRFPQL
Protein: Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Q6NZZ9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity). Required for normal early embryogenesis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9NW64}. Cytoplasm {ECO:0000250|UniProtKB:Q9NW64}. Note=Nearly exclusively nuclear. May be shuttling between the nucleus and the cytosol. {ECO:0000250|UniProtKB:Q9NW64}.
Interaction partners:
- Protein BUD31 homolog
- SNW domain-containing protein 1
- Crooked neck-like protein 1
- Pre-mRNA-splicing factor SYF1
- Elongation factor Tu GTP-binding domain-containing 2.
- Pleiotropic regulator 1.
- Cell division cycle 5-like protein
- Cell division cycle 40 homolog
- Pre-mRNA-processing factor 19
- Activating signal cointegrator 1 complex subunit 3
Sequence:
MATSLGSNTYNRQNWEDSDFPILCQTCLGENPYIRMTKEKFGKECKICARPFTVFRWCPGVRMRFKKTEVCQTCSKMKNVCQTCLLDLEYGLPIQVRDTGLSVKDEVPRSDVNKEYYTQNMEREIANSDGTRPVGLLGKAPSSSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVANKLLMRASTMPRLDVPDDKSITTLYIGGLGENVTDSELRNHFYQFGEIRTITIVQRQQCAFIQFATRQAAETAAEKSFNKLIINGRRLNVKWGRSQAARGKGEKDGVTESGIRLEPVPGLPGALPPPPVSDEDASTNYFNLAPTPSPAVMNLGLPPPPGVTMPPPPGFGPPMFHTMDPMAPPVPPPMALRPPGQVHYPSQDPQRMGAHASRHGGP
Protein: Protein tyrosine phosphatase domain containing 1 (A0A087WTF0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQVQDATRRPSAVRFLSSFLQGRRHSTSDPVLRLQQARRGSGLGSGSATKLLSSSSLQVMVAVSSVSHAEGNPTFPERKSKGNLERPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTPLRNIFSCCDPKAHAVTLPQYLIRQRHLLHGYEARLLKHVPKIIHLVCKLLLDLAENRPVMMKDVSEGPGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGMIFSNEQQFDPLWKRRNVECLQPLTHLKRRLSYSDSDLKRAENLLEQGETPQTVPAQILVGHKPRQQKLISHCYIPQSPEPDLHKEALVRSTLSFWSQSKFGGLEGLKDNGSPIFHGRIIPKEAQQSGAFSADVSGSHSPGEPVSPSFANVHKDPNPAHQQVSHCQCKTHGVGSPGSVRQNSRTPRSPLDCGSSPKAQFLVEHETQDSKDLSEAASHSALQSELSAEARRILAAKALANLNESVEKEELKRKVEMWQKELNSRDGAWERICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRRADAAEALFLLEKGQHQTILCVLHCIVNLQTIPVDVEEAFLAHAIKAFTKVNFDSENGPTVYNTLKKIFKHTLEEKRKMTKDGPKPGL
Protein: Uncharacterized formamidopyrimidine-DNA glycosylase-like protein (L0T864)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized oxidoreductase Rv0945
- Endonuclease 8 2 lyase Nei 2)
- Formamidopyrimidine-DNA glycosylase 1
- Uncharacterized protein Rv0943c
- DNA polymerase I
- Adenine DNA glycosylase
Sequence:
MAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSGAQLTCLHEAMASVLSDAVRRSVGQGAAMLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK