wanglab/gogpt-training-data huggingface dataset:
Protein: Chitin synthase chs-1 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase chs-1) (G5ECD6)
Organism: Caenorhabditis elegans
Function: Essential for the embryonic synthesis of chitin, a component of the eggshell.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17869112, ECO:0000269|PubMed:20971008}; Multi-pass membrane protein {ECO:0000255}. Note=egg-1, egg-2 and egg-3 maintain the homogenous distribution of chs-1 at the unfertilized oocyte cell membrane, thus ensuring the formation of a continuous and cohesive eggshell chitin layer (PubMed:17869112, PubMed:20971008). In the fertilized embryo, co-localizes with egg-3 to cytoplasmic foci in an egg-3-dependent manner (PubMed:17869112). {ECO:0000269|PubMed:17869112, ECO:0000269|PubMed:20971008}.
Interaction partners:
- Protein tyrosine phosphatase-like protein egg-3
- Probable UDP-N-acetylglucosamine pyrophosphorylase
- Chitin synthase chs-2
- Inactive protein-tyrosine phosphatase egg-4
- Chitin-binding domain protein cbd-1
- LDL receptor repeat-containing protein egg-1
- Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2
- EGF-like domain-containing protein
- LDL receptor repeat-containing protein egg-2
- Chondroitin proteoglycan 1
Sequence:
MNDGENYWNAFRSHKRSATDGPTLSPWMVTVLQATKLLLFALCNIVLTLGSVFSKLIVLIMATNIVPRAHLIGKFARKCTKAAVRRTSTTTAGIYLSLLLIQCFPDTINLIRSGIDMWKGQCGQLVKSVVVLESLRAIGLAVLSFHVFPQLDLARCLVLSACFPLVAVLQRSLVAMVSAARTGRSFRNRLGRCFVAIPHVIMFLVLMSSCYVWALFDNKFTAIIALPIGVICTSAGFWESWIDTTHSGTSFDELYRLKYAVRKMNTTTKLIVSLMRIVCTVSVLVSAVYINDHKKLNSSHFVKAFFSFSTRQPHTRLLLLATGIIVLHFVMRGISRFLAALDLHPFSFVHPLSIAPLIAYGYVRYACQSPTCSIARRLARFGLHWVCDQWFQSARGIASPDFYICLIWLLVGCYRGWRLVRQRYFDTNEEIISSMPPVCNGLCIEQSLVVFQHSLNRQEKTMLTEEEDISDENDELRIRNDEVDRVSTVYGCATMWHETETEMRQVLRSILKLDVDHATRMNNKKANELRYRLEGHIFFDDAWEDVEEDGIEKRQPNEYFNMFFDLLNEMTGERLNEEGKMETRILVNTPYGGRLVVKLPSGTLLFVHLKDKKMIRHKKRWSQVMYMYYLLGHRIMDCPLSIEDRQQMADNTFILAIDGDSKFEPDALLRLLHLMNAKSDIGCACGRIHPIGNGIMVWYQKFEYAIAHWFQKAAEHVFGCVLCAPGCFSLFRASALMDDNIMHKYTKTASEPRHYVQYDQGEDRWLSTLLLKQGYRIEYAAASDAETYAPEGFEEFFNQRRRWTPSSIANTVDLLMDYKRASENNDAISYAYIAYQFLVIFFSMLGPAIIFTMLVFAQVAAFELRGSDVMLYNGIPIGFFIVLCFTTESNIQLIYAKYMSIAYAFVMLAVLVATSSQIVLETVLAPTSLFIVTMVGIFFFAACLHPKEFTNIIHGVVFFLMIPSTYVFLTLYSLINLNVITWGTREAVAKATGQKTKKAPMEQFIDRVIDIVKKGFRLISCREKKEHEERREKMEKKMQRMELALRSIESGADVKKILDATEEKEKREEETQTADFPIEENVEKTQKEIQKANRYVWMTSHSLKVCERGKLKSAEKVFWNELINAYLKPIKTTPAEMKAVAEGLASLRNQIAFTILLVNSLLALAIFLIQKHKNVLSIKFSPIKNFRWTKMNEMTGQYEETDEPLKIDPLGMGIVVFLLIILFVQTLGMLLHRLNTMIGAFQEVKNLYEYGVSPVINTKNDDERIMNNARLMINSLGVSTGHAADGYTRHRGEESDTGNVLYKLQKARLAKRMQRSALSTTE
Protein: Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2) (Q9NZ42)
Organism: Homo sapiens (Human)
Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12639958}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12639958}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Cell membrane {ECO:0000269|PubMed:24941111}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517}. Membrane {ECO:0000269|PubMed:12198112}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000269|PubMed:12639958}.
Interaction partners:
- Presenilin-1
- Presenilin-2
- Nicastrin
- Gamma-secretase subunit APH-1B
- Gamma-secretase subunit APH-1A
- Transmembrane emp24 domain-containing protein 10
- Amyloid-beta precursor protein
- Neurogenic locus notch homolog protein 1
- Beta-secretase 1
- Tumor necrosis factor
Sequence:
MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP
Protein: AT5g19120/T24G5_20 (Eukaryotic aspartyl protease family protein) (Q93VG3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At2g17880
- DnaJ domain protein
- Glutaredoxin-C11
- AAA-ATPase At3g28600
- Secreted transmembrane peptide 6
- 15.4 kDa class V heat shock protein
- Histone H1
Sequence:
MASSSCLNLFFFSFLSALIISKSQISDSVNGVVFPVVKDLPTGQYLAQIRLGDSPDPVKLVVDLAGSILWFDCSSRHVSSSRNLISGSSSGCLKAKVGNERVSSSSSSRKDQNADCELLVKNDAFGITARGELFSDVMSVGSVTSPGTVDLLFACTPPWLLRGLASGAQGVMGLGRAQISLPSQLAAETNERRRLTVYLSPLNGVVSTSSVEEVFGVAASRSLVYTPLLTGSSGNYVINVKSIRVNGEKLSVEGPLAVELSTVVPYTILESSIYKVFAEAYAKAAGEATSVPPVAPFGLCFTSDVDFPAVDLALQSEMVRWRIHGKNLMVDVGGGVRCSGIVDGGSSRVNPIVMGGLQLEGFILDFDLGNSMMGFGQRTRSDSTSL
Protein: Even-skipped homeobox 2 (Homeobox even-skipped homolog protein 2) (Q6PFR9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Limb and neural patterns a.
Sequence:
MMERIRKEMILMERGLHSPVAGKRLSNLTDSAGNAVLEALENSQHAGRLSPRITSASLHGDIPTKGKFEIDSLFGNHHNDNTSSTEVSSSESRKKINLYPEVSPDSDMNSDVEVGCPSHRSPGSISQHKENNNKGFSDSNSGGSNTSSSSLSNLNGNSMGNSSSSSDQVRRYRTAFTREQIGRLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMSWPHPADPSFYTYMMTHAAATGSLPYPFHSHMPLHYYPHVGVTAAAAAAAASGAASSPFATSIRPLDTFRALSHPYSRPELLCSFRHPGLYQSPAGLNSSAAASAAAAAAAAAAAVSAPSATGPCSCLSCHSSQAASALGSRSSSSDFTCTATGQRSESGFLPYSAAVLSKTAVPSPDQREESALNR
Protein: Inactive C-alpha-formylglycine-generating enzyme 2 (Sulfatase-modifying factor 2) (Q8BPG6)
Organism: Mus musculus (Mouse)
Function: Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q8NBJ7}.
Interaction partners:
- Formylglycine-generating enzyme
- Arylsulfatase A
- Arylsulfatase B
Sequence:
MRSEFWFPSMGSLLPPVLLLWLLSCPRLQLGHAQDPAMVHLPGGRFLMGTDAPDGRDGEGPAREVTVKPFAIDIFPVTNKDFREFVREKKYQTEAEAFGWSFVFEDFVSPELRKQENLMPAVHWWQPVPKAFWRQPAGPGSGIREKLELPVVHVSWNDAGAYCAWRGRRLPTEEEWEFAARGGLKGQVYPWGNRFQPNRTNLWQGKFPKGDKAEDGFHGLSPVNAFPPQNNYGLYDLMGNVWEWTASTYQPAGQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCASSAGRPKEDL
Protein: Leukocyte cell derived chemotaxin 2 (D6RGX8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFSTKALLLAGLISTALAGPWANICAGKSSNEIRTCDRHGCGQYSAQRSQRPHQGVDILCSAGSTVYAPFTGMIVGQEKPYQNKNAINNGVRISGRGKRGGVYTWGASWRC
Protein: Invariant surface glycoprotein (B2ZWC1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MARVTFCLAVVLITSSASVFSHVGKARASETQTNEAEDKLSRAAADVLCIMTDLTRKVVNPLADRLAELAAEDTANITRDAELVNTYVDDIDGMLGKDSDDPDGTKKRIKELCDGAKTKVKDMPENARNREASIKEKAVKAKESGKKTLEGTEASEGGNPVVGLKEVMSSYCRGGRKCEEGVVSSTLDPPEGEISCTNVTLDEKEKWISTLMVEAGANWTTSKPKKVVNCSTAGEPPCTPLDQWGTHYNDTKSHVVRIVGELDESYKDMLICENQLLLVYKIHKGLQEQRNHSEIISEGERVGNRTLSEMNELADNYLSSSLEGGVNNTDLQDLEEARTASTRRRRWIMLLLLCVLIPIAVVLIFALVFFLLWKRRKAAPKEASAAAVAQPKL
Protein: Mitogen-activated protein kinase kinase kinase 14 (O64741)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Inactive serine/threonine-protein kinase BKN2
- Protein kinase family protein
Sequence:
MEKQNIISNTSSSSSSWIRGSCVGRGCFGTVSKALSKIDGGLFAVKSIDLATCLPSQAESLENEIVILRSMKSHPNIVRFLGDDVSKEGTASFRNLHLEYSPEGDVANGGIVNETLLRRYVWCLVSALSHVHSNGIVHCDVKSKNVLVFNGGSSVKLADFGSAVEFEKSTIHVSPRGSPLWMAPEVVRREYQGPESDVWSLGCTVIEMLTGKPAWEDHGFDSLSRIGFSNDLPFIPVGLSELGRDFLEKCLKRDRSQRWSCDQLLQHPFLCQDHHDSFFTESSPRCVLDWVNSEFDEEEESDEWRPESMVSAMARISKLAITGGANWESNGWTEVRDTSEESEAKKEVLVSPRVELESYISLESSSDDSVRQPRNEESATELASAVTCEAILLVMILVVENIQIYATFYTSSIIMHILYCCSCCCYYHYQNNNKKNNFSKSTSFILSLNFLFGIACDSDRSIY
Protein: Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A) (Q13219)
Organism: Homo sapiens (Human)
Function: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Subcellular location: Secreted {ECO:0000269|PubMed:10077652}.
Interaction partners:
- Bone marrow proteoglycan
- Insulin-like growth factor-binding protein 5
- Insulin-like growth factor-binding protein 4
- Stanniocalcin-2
- Insulin-like growth factor 1
- Galactoside-binding soluble lectin 13
- Acidic leucine-rich nuclear phosphoprotein 32 family member E
- Placenta growth factor
- Insulin-like growth factor 2
- Alpha-fetoprotein
Sequence:
MRLWSWVLHLGLLSAALGCGLAERPRRARRDPRAGRPPRPAAGPATCATRAARGRRASPPPPPPPGGAWEAVRVPRRRQQREARGATEEPSPPSRALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQRSPAVITGLYDKCSYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRARQVTTINAHRSYLPGQWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLMLGGSALNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDNVKHAWSPMKDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYNQLSSFRQPKVVRYRVVNLYEDDHKNPTVTREQVDFQHHQLAEAFKQYNISWELDVLEVSNSSLRRRLILANCDISKIGDENCDPECNHTLTGHDGGDCRHLRHPAFVKKQHNGVCDMDCNYERFNFDGGECCDPEITNVTQTCFDPDSPHRAYLDVNELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEALMHLGGIVLNPSFYGMPGHTHTMIHEIGHSLGLYHVFRGISEIQSCSDPCMETEPSFETGDLCNDTNPAPKHKSCGDPGPGNDTCGFHSFFNTPYNNFMSYADDDCTDSFTPNQVARMHCYLDLVYQGWQPSRKPAPVALAPQVLGHTTDSVTLEWFPPIDGHFFERELGSACHLCLEGRILVQYASNASSPMPCSPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQGCYLELEFLYPLVPESLTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLTIRLWDVGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDPPLQMDVASILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIHGSGYCGDGIIQKDQGEQCDDMNKINGDGCSLFCRQEVSFNCIDEPSRCYFHDGDGVCEEFEQKTSIKDCGVYTPQGFLDQWASNASVSHQDQQCPGWVIIGQPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQLAQTTFWLRAYFSQPMVAAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCRNNPLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYSPAEQSCVHFACEKTDCPELAVENASLNCSSSDRYHGAQCTVSCRTGYVLQIRRDDELIKSQTGPSVTVTCTEGKWNKQVACEPVDCSIPDHHQVYAASFSCPEGTTFGSQCSFQCRHPAQLKGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKPGYHVPGSSRKSKKRAFKTQCTQDGSWQEGACVPVTCDPPPPKFHGLYQCTNGFQFNSECRIKCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNELNSNLKLQCPDGYAIGSECATSCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGLKWYPHPALIHCVKGCEPFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPQAQEHSRKDLRGYSHG
Protein: Clustered mitochondria protein homolog (O15818)
Organism: Dictyostelium discoideum (Social amoeba)
Function: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
Interaction partners:
Sequence:
MSETIDNPTVEEYNEKETVVSGEQVEQVEQVEQENEQVSQSFQISIKTPAEIGTINIQVQPTDTLIDIQSFLYETSETCLYSSFEFRLYGKQIPEYSELSSIEGLVEGATLEMVPVDYNERSAKLHVKRLRDIMNTGLTEFANMNNPSLFTSFSFPEKSNILTEEQQLEEQKQKFEQQQQQQQQTEDKEEKETIATEQQQNKKNKHHNKKGNKKNNGDESLNNENNEEKLTPQQKERKQKMTEIKGIDKPMLSSYYPESPIAPVQCVKSMIYSGWSPVPGYRKLFGDLFYLDITLLEGTTICVTASTQGFFINQSSNATFNPSVSPKATINHSLHQLLTQVSRLFRRGLNQILTNIGRNHPFDMLPGVLPVHNWVASSKTNRYDINKGTDTFVSVQDVELRGNPRDWNEEIQAPKELPKSTVQERIIRDRAISKVNSEFVECAIRGAQVIVDKAILPINPAENQRSHMFLYNNIFFSYALDTRDSFTDCGGDDAARTSANNDLKGIRLYNLADIDGLYTLGTAIVDYKGQRIIAQSLIPGILTTEKTSKIYYGSMDTPTNEEEEQQQKEENEENKNNNTKSIKADPEFHSRLLQAASLLHLSESKVISEDTNQEVSVCTSFESKGIIGIDGRRYILDLIKATPRDPNYTETKDQLSVLRPEAIATYSEYFKVTWLNQKRQQKLKEKEERQKKEGIDPPTATARDEDVQLTEEDLAQSPVVSFNPNLFSKVKLGGTPEEQQKDIEDLKAIGAFLKGILIPRLIEDLMLFNVAPVDGQTLTQVMHVRGINMRYLGYIAKNESANVPFIQDLLFNEMVSRAAKHCFNRLLRSTNASDMAHSISHFLNCFLGTETGSVSADEKSKKAKQIKSSAINELTQGKLWSEIAQLVSSKFDFEIPTHSVPMESRLIVLRCICLKMGIQILAKDYNFTTDAPFSPEDIVDLFPIVKHVNPRSTDGLDLLEAGKTFFNQRKYELATELLGEALAIYHQVHGPIHPDAGACFTHLAMLAYQNEQYDLAIEYQKNALVITEKTAGLDHHETVQAYTTLAVFCQRSGRYNESIGYMKHVLYLTDLLGGEYNPERASIYTAIAAILEDTERFDLALEFLKQTLKHQEFLFTPDHLMCSTTYHKMAIVCARATNFDDSIIHQKKSTDILEKELGEAHPRTKESLEFYTGLSQTANQIKLFKQHQALKAEQDELARLQKEKADQFKKSQPRVSAMPPSLENGSVSELLNYINGKPKKSQSKKSKSTNTTTTTNTTTATTSKSKITMAKTPNPTTKATTSKSSATASSAATNKSTTKTNPTSSSAADSSKPNKKSSKN
Protein: CD42_CHICK Cell division control protein 42 homolog (G25K GTP-binding protein)MODA (G5EAY4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}.
Interaction partners:
- Rho GTPase activator Rga
- Guanine nucleotide exchange factor Cdc24, putative
- Protein kinase activator Bem1, putative
- Serine/threonine-protein kinase ste20
- non-specific serine/threonine protein kinase
- Uncharacterized protein
- SH3 domain protein
- Rho GDP-dissociation inhibitor
- Cytokinesis protein sepA
- High osmolarity signaling protein sho1
Sequence:
MVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQVDLRDDPAVRDKLARQKMQPIRKEDGDRMAKDLGAVKYVECSALTQYKLKDVFDEAIVAALEPAPKKRSRCVLL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q499L9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTESFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
Protein: Mitochondrial import inner membrane translocase subunit TIM9 (O74700)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM10, it may have a strong structural role.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:9822593, ECO:0000269|PubMed:9889188}; Peripheral membrane protein {ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:9822593, ECO:0000269|PubMed:9889188}; Intermembrane side {ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:9822593, ECO:0000269|PubMed:9889188}. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM13
- Mitochondrial import inner membrane translocase subunit TIM8
- Mitochondrial import inner membrane translocase subunit TIM10
- Mitochondrial import inner membrane translocase subunit TIM12
- Mitochondrial import inner membrane translocase subunit TIM54
- Mitochondrial import inner membrane translocase subunit TIM22
- Mitochondrial import inner membrane translocase subunit TIM18
- Mitochondrial intermembrane space import and assembly protein 40
- Succinate dehydrogenase cytochrome b subunit
- Mitochondrial import receptor subunit TOM22
Sequence:
MDALNSKEQQEFQKVVEQKQMKDFMRLYSNLVERCFTDCVNDFTTSKLTNKEQTCIMKCSEKFLKHSERVGQRFQEQNAALGQGLGR
Protein: Serine/threonine-protein kinase PLK (EC 2.7.11.21) (Polo-like kinase) (Q38DT1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIGTVEQILYEEGCVRAVRVRLPSRDSSQGKCLSLEACERIGQGSFGTVYRASCDEYPRLALKITTGKVTRLKQELEVLGRVCTKGKLLLPRFLFGALNKSGDLMAVGMELCFPHTLHDFLLSKCLTDEADKLFVAYQVVQAVAYVHEQHCIHRDVKLQNFVFDLDGNLKLIDFGLATSVWNPPPGDVVAGTIAFMAPEMAHNALHRDQRVSVGAAADVWSVGMVLFSIFAQRNPYASTGAPRMTERTADTNMHNTAAIPTDASPNDKQSHEIPKENAELLRRVAAAEWSWPSGCSVSRKLRGLVDFVLVPDPQNRPDINALLMRPEWGDRRRATPRVVTTFLGVEDDFLLSHDESHLLRAVEQRSADVNASLTESRIRGSDEEETEEGHRSSLKFVAREELSVGGVPIHQVYDVRPDPKVKKPIREISSVIAEETERSLKRSRSRSARAAASSASRANSRVNARSRTVTPVPCTTEGRGNADFPTGSAAASLVLLEAEGKEETKTGLNIGQRSPQGRQPRSNNVDRAKGINLVGKRDPKPKSANGTVQRSTSPIEHTVDTKRGGGNNSHGVGARRGSTVTARKKKGNGAEVVSGFVTMENAVRNVKTSLLLLEHSCMVTRLSTVVTELFDREHMVWLEKEQRKSATHPHTFREMGRANKKYRYGFVCDVCCFEFEPVGSSMYFFHCQCGRDMCPKCYEEYANNYTCDACGREFASSGALRRHSCSCVKRLNDAATVNKPRGRSQGRRSRSVPTEAARTGVKSRLEVKPVSPKRGRPKRRASVPALERKRSREPAAEVVGIVARRKAERLSMSKSEVVPPPRRFEGIPRTLSGEWKPMERLSVGSRSVPPTPEERHMLLNGDWIRYYHFYPMEEEGGDSVAVTYHIQPGRTGVTFFNHSFSVHSAVLSVLEHIVYVVDRVDIEEDNDVARILSLAQALNEEKKIYDVLQLVETHDTHMLKQRRSPGIMSVYCPPQTAFQCNGDPFVFVRWYRFHMENSMSGFMLSNGAVQVFVGGKYELRWLDDNRKFIVRSNGVCEVLDEEKFPLSEELNQMLYGGV
Protein: Non-specific serine/threonine protein kinase (H2KYA8)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPVGNSGSRSGRLARISQSNIRPFGSNGGGATNSYGPGTHPMSGAEPCSPTKKEKHRFEITKKLGSGTYGKVSLAYDHKFDREVAVKLIKKSAIESKADLVRIRREIRIMSALNHPNIIQIYEVFENKDKIILVMEYSSGGELYDYVSRCGSLPEAEARRIFRQITSAVLYCHKHRVAHRDLKLENILLDQNNNAKIADFGLSNYFADKNLLTTFCGSPLYASPEIINGTPYKGPEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYFEPETPSTASMLIRNMLRVNPERRATIFDIASHWWLNLEENMPVIQELPENQIIDHTPLTEREETMIVQDLADEQDVFMEFGHLSSETRRKIEDFRIRRKEAEEFNDNSPVKPPKARKTDELTGKISKEQPEEMKSAEKSLRGVKEEKEKPKVVDPNDPLERLRQIENRLGQNKKDKEAAKTSARVETVKLKEVKKEKSPEQQPEDPKTARGTSKPADSRAPSFVPVKDRPETSEPERPRTRPHLTASAYRIETDSLNMLMNQVLEQMEKGPVNLNIIARIKAHPLYDTRPMVKELLESIIAAQPEPVQKQTSKVVEQQTFSRQNTLTRKKKEDPLEEEIPEVPSPSRKMKERPWHSVEVGFDPDEEPEHDRMQESIASNATEVTVQDTSFEDDSSDEEERKKTPVASTPKTPVLIVEKQESSTNAEDEESDEGDDYSDAEMEELADEVDKKGPSDSKLAPVVENLEANPPPDPSSSPQFLDAFDRGLIKRQSKGKYQHTLINNYGRGVSTECESPTQQRKFFGGPQPSAELSPFLFDKAKEILQTYPNNKLDARGIDVELRRKLRMEKVKADLLKQPKDGDKPRNSYVGSVPPRSPPPIVVKSDGEELDDEEEEEEDEEEIEETDSEEGSDFENFKPKRPIIAAVRRDDGEKVPVAGTSAKYLVTVAELKLKPTDKKEEAQLKEQLKDSEINSERKTSQTNLLFRPSAYRESDLYRRINAALERPSVDPYDDRAFSPLSTDPFYSHHSSGSAAPSALGYVRPRYHDDSYRTHRDSDYRPMSPTSRYTAAVTRDDRGKSTSYDPHETTRPSYDRGYITSSNASPSYTRKFEHEQPTLNSWANDRKFEVYKTRAERDAERNTYHPTGTTGASSYRPSSYYTSASDRPVTGLRRPEESYTSSTNYGRYDGRSTTPSNDQYAISTALAENQASSMNNRFRPTARRVASAMTDADRRNYHRSRSMDRNKVDYEYGSNLLNRLTTPDSHGDYSYVNYHDSSNGRSNITLEKDGQPRSILKNKQSADIEPRVESSYEPSNGVRSVFERLRRHLSLEKSVSPQRQVASVGPHSRNIDSTSSALDNPKKKRSLLSFNRRKTSEVRMGADGKLVTNGYDSTPSSRDFKRPSSPIDRIKSLFRKNESSGTGHSDYYNSSRNYTSSNPVSTTREPYVAQYRKYPGSTSRDTSSALNRYSYTPGLTDQRRHWYDDPNIY
Protein: Phosphomevalonate kinase (PMKase) (EC 2.7.4.2) (Q5RK24)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514, ECO:0000256|PIRNR:PIRNR036639}.
Interaction partners:
- Diphosphomevalonate decarboxylase
- Mevalonate kinase
- Isopentenyl-diphosphate Delta-isomerase 1
- Lanosterol synthase
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Transmembrane 7 superfamily member 2.
- Farnesyl pyrophosphate synthase
- Squalene synthase
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
Sequence:
MAPLGASPRLVLLFSGKRKSGKDFVTERLQSRLGGNICAVLRLSGPLKEQYAREHGLDFQKLLDASTYKETYRRDMICWGEEKRQADPGFFCRKIVEGVSQPIWLVSDTRRMSDIQWFQEAYGALTQTVRVVASEQSRQQRGWVFTRGVDDAESECGLDSFGDFDWVIENHGDEQCLEDQLENLLEFIHAKLQR
Protein: Early nodulin-like protein 13 (AtENODL13) (Early nodulin-like protein 3) (Phytocyanin-like protein ENODL13) (Q8LC95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12805588}.
Interaction partners:
- Nodulin-like protein
- Protein BREAKING OF ASYMMETRY IN THE STOMATAL LINEAGE
Sequence:
MAQRTLVATFFLIFFLLTNLVCSKEIIVGGKTSSWKIPSSPSESLNKWAESLRFRVGDTLVWKYDEEKDSVLQVTKDAYINCNTTNPAANYSNGDTKVKLERSGPYFFISGSKSNCVEGEKLHIVVMSSRGGHTGGFFTGSSPSPAPSPALLGAPTVAPASGGSASSLTRQVGVLGFVGLLAIVLL
Protein: Cytochrome P450 1A1 (CYPIA1) (EC 1.14.14.1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (P04798)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Microsome membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Cytoplasm {ECO:0000250|UniProtKB:P00185}.
Interaction partners:
- Glutathione S-transferase Mu 1
- Cytochrome P450 3A4)
- UDP-glucuronosyltransferase 1A6
- UDP-glucuronosyltransferase 1A7
- Catechol O-methyltransferase
- UDP-glucuronosyltransferase 1A4
- UDP-glucuronosyltransferase 1A10
- UDP-glucuronosyltransferase 1A1
- Epoxide hydrolase 1
- UDP-glucuronosyltransferase 1A8
Sequence:
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
Protein: Beta-ketoacyl-ACP reductase-like protein (NAD(P)-binding Rossmann-fold superfamily protein) (Q67Z59)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSNHQTVLKQLEPWCELKDKVVLVTGASSGIGREICLDLAKAGCQVIAAARRVDRLNSLCSEINSFSSTGIQAAALELDVSSDAATIQKAVREAWDIFGKIDALINNAGIRGNVKLSLDLSEDEWDNVFNTNLKGPWLVAKYVCVLMRDAKRGGSVINISSVAGVRSIVPGGLAYSCSKGGVDTMSRMMAIELGVHKIRVNSIAPGLFKSEITQALMQKEWLKNVTERTVPLKVQQTIDPGLTSLVRYLIHDSSQYISGNTYIVDSGATLPGVPIFSSL
Protein: Zinc finger protein 497 (Q6ZNH5)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MESPRGWTLQVAPEEGQVLCNVKTATRGLSEGAVSGGWGAWENSTEVPREAGDGQRQQATLGAADEQGGPGRELGPADGGRDGAGPRSEPADRALRPSPLPEEPGCRCGECGKAFSQGSYLLQHRRVHTGEKPYTCPECGKAFAWSSNLSQHQRIHSGEKPYACRECGKAFRAHSQLIHHQETHSGLKPFRCPDCGKSFGRSTTLVQHRRTHTGEKPYECPECGKAFSWNSNFLEHRRVHTGARPHACRDCGKAFSQSSNLAEHLKIHAGARPHACPDCGKAFVRVAGLRQHRRTHSSEKPFPCAECGKAFRESSQLLQHQRTHTGERPFECAECGQAFVMGSYLAEHRRVHTGEKPHACAQCGKAFSQRSNLLSHRRTHSGAKPFACADCGKAFRGSSGLAHHRLSHTGERPFACAECGKAFRGSSELRQHQRLHSGERPFVCAHCSKAFVRKSELLSHRRTHTGERPYACGECGKPFSHRCNLNEHQKRHGGRAAP