wanglab/gogpt-training-data huggingface dataset:
Protein: T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g) (P09693)
Organism: Homo sapiens (Human)
Function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8636209}; Single-pass type I membrane protein.
Interaction partners:
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface glycoprotein CD3 delta chain
- T-cell surface glycoprotein CD3 zeta chain
- Tyrosine-protein kinase ZAP-70
- Tyrosine-protein kinase SYK
- T-cell surface glycoprotein CD8 alpha chain
- CD8 subunit beta
- T-cell surface glycoprotein CD4
- T-cell receptor-associated transmembrane adapter 1
- Beta-2-microglobulin
Sequence:
MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN
Protein: Sodium channel protein (H9KVD2)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
Interaction partners:
Sequence:
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Protein: Calcium/calmodulin-dependent protein kinase type II (CaM kinase II) (EC 2.7.11.17) (Uncoordinated protein 43) (O62305)
Organism: Caenorhabditis elegans
Function: Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria. Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16079277}. Cell projection, axon {ECO:0000269|PubMed:15625192}. Perikaryon {ECO:0000269|PubMed:15625192, ECO:0000269|PubMed:16079277}. Note=Localizes at or near the Golgi apparatus (PubMed:16079277). Localizes to post-synaptic regions and is enriched in punctate structures in axons of AWC neurons where it co-localizes with tir-1. Localization is regulated by tir-1 (PubMed:15625192). {ECO:0000269|PubMed:15625192, ECO:0000269|PubMed:16079277}.
Interaction partners:
- Calmodulin
- EF-hand domain-containing protein
- Calmodulin-like protein
- Calmodulin-like protein
- Uncharacterized calcium-binding protein B0563.7
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Potassium voltage-gated channel protein eag
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
Sequence:
MMNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVASAIHRQDTVDCLKKFNARRKLKAAISAVKMVTRMSGVLRTSDSTGSVASNGSTTHDASQVAGTSSQPTSPAAEVYPNVLLFNPQKFPRNCVHPFTTHPYYSPKESSKKKLFFTLLFEVCPHTSRSHILLRDNTKNIYHPYHCFTNKMSNYERAAPSSHGSSTTKKIANAIADLVIRRSSPSIRRKTEADVHNSNRNRKVSAPANLQHALVPVIDVVVATGALASSSVDNLSASTSSDLGRNLLNKKEQGPPSTIKESSESSQTIDDNDSEKGGGQLKHENTVVRADGATGIVSSSNSSTASKSSSTNLSAQKQDIVRVTQTLLDAISCKDFETYTRLCDTSMTCFEPEALGNLIEGIEFHRFYFDGNRKNQVHTTMLNPNVHIIGEDAACVAYVKLTQFLDRNGEAHTRQSQESRVWSKKQGRWVCVHVHRSTQPSTNTTVSEF
Protein: Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) (Q9D958)
Organism: Mus musculus (Mouse)
Function: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P83362}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P83362}.
Interaction partners:
- Signal peptidase complex subunit 2
- Signal peptidase complex subunit 3
- Signal peptidase complex catalytic subunit SEC11A
- Signal peptidase complex catalytic subunit SEC11C
- Adipocyte-related X-chromosome expressed sequence 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Gastrin-releasing peptide
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
- Protein transport protein Sec61 subunit gamma
- Signal recognition particle 19 kDa protein
Sequence:
MARGGARGCPCPSETSASGATAEVKRSAGRPCSRYRPPQTLLLNNRLRPFRCRYRSSATMLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYVAEQFGWTVYIVMAGFAFSCLLTLPPWPIYRRHPLKWLPVQDLGTEDKKSGDRKIKRHAKNN
Protein: Tapasin (Q3SAU8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MANISTIYKLSFLAFTYFIQVYGTSCPVLECWFVQEKPGRGGGFPAAMIQEKSLLYINTDPESEQTKSQQGPSADISHDRVYYITDPAAILCSSSLHPPEGSVHKPQCEINPFMPQPSTVQWAVPLTDSAHSPIYLQADWYSAALQGLDGQLALSSVMRAPTATKEPTVVLSVSSRTPLVRSRLGEPVVLDCGFWAETSSPLSGSGFTVEWRYQFRGDGRLVLAYDGKTDRFAETKEKGAGLDFTALHETGNASLILQEAEVRHTGTYICTVYLPYLLAQVAVELEIVEPPSLSIFPSPLPLSVPGQVVKVQCEASGFFPLSLEFYWELTGPDGKVRPLGQGSVTGHRQGPDNTYSQTTRLELDSAKLDLGRGGEVTCVAVHPGGTRRARVTLNVIGVNGPSIEDSMAMVAVALGLYGLIKIVSWTFSSGSDDTNSQEKKVK
Protein: Ras-related protein Rab-22A (Rab-22) (Rab-14) (P35285)
Organism: Mus musculus (Mouse)
Function: Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (By similarity).
Subcellular location: Endosome membrane {ECO:0000269|PubMed:27718357}; Lipid-anchor {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor {ECO:0000305}. Early endosome {ECO:0000269|PubMed:19759177, ECO:0000269|PubMed:27718357}. Late endosome {ECO:0000250|UniProtKB:P51154}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9UL26}. Cytoplasmic vesicle {ECO:0000269|PubMed:27718357}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9UL26}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250|UniProtKB:Q9UL26}.
Interaction partners:
- Rabenosyn-5
- Ras-related protein Rab-31
- Rab5 GDP/GTP exchange factor
- DCC-interacting protein 13-beta
- Geranylgeranyl transferase type-2 subunit alpha
- Early endosome antigen 1
- DCC-interacting protein 13-alpha
Sequence:
MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVRELRQHGPPSIVVAIAGNKCDLTDVREVMERDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSTDANPASGGKGFKLRRQPSEPKRSCC
Protein: Protein SULFUR DEFICIENCY-INDUCED 2 (Q8L730)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the utilization of stored sulfate under sulfur-deficient conditions.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SUC3}.
Interaction partners:
- Protein RESPONSE TO LOW SULFUR 2
- 5'-adenylylsulfate reductase 3, chloroplastic
- 5'-adenylylsulfate reductase 1, chloroplastic
- Berberine bridge enzyme-like 18
- 5'-adenylylsulfate reductase 2, chloroplastic
- 1-aminocyclopropane-1-carboxylate oxidase homolog 2
- At1g49000
- At3g04640
- At1g12030
- Phospholipase-like protein
Sequence:
MMMMIQRRGGERQDSSAAAYNVVHKLPHGDSPYVRAKHVQLVEKDAEAAIELFWIAIKARDRVDSALKDMALLMKQQNRAEEAIDAIQSFRDLCSRQAQESLDNVLIDLYKKCGRIEEQVELLKQKLWMIYQGEAFNGKPTKTARSHGKKFQVTVEKETSRILGNLGWAYMQLMDYTAAEAVYRKAQLIEPDANKACNLCTCLIKQGKHDEARSILFRDVLMENKEGSGDPRLMARVQELLSELKPQEEEAAASVSVECEVGIDEIAVVEGLDEFVKEWRRPYRTRRLPIFEEILPLRDQLAC
Protein: LIM domain-containing protein WLIM2b (Widely-expressed LIM protein 2B) (Q9M047)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to actin filaments and promotes cross-linking into thick bundles. Has an actin-stabilizing activity. The actin regulatory activities are not regulated by pH and [Ca(2+)].
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20817848}.
Interaction partners:
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Protein CLT2, chloroplastic
- Propionyl-CoA carboxylase
- Tubby-like F-box protein 5
- 
Sequence:
MSFTGTQQKCKACEKTVYAVELLSADGVGYHKSCFKCTHCKSRLQLSSYSSMEGVLYCKPHFEQLFKESGSFNKNFQSPAKSADKSTPELTRTPSRVAGRFSGTQEKCATCSKTVYPIEKVTVESQTYHKSCFKCSHGGCPISPSNYAALEGILYCKHHFAQLFKEKGSYNHLIKSASIKRSAAAAVAAGVPAASVPES
Protein: Protein BANP (A0A0S2Z5C2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMSEHDLADVVQIAVEDLSPDHPVVLENHVVTDEDEPALKRQRLEINCQDPSIKSFLYSINQTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCAVPGRRQNTIVVKVPGQEDSHHEDGESGSEASDSVSSCGQAGSQSIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPNSSSYCPSEPMMSTPPPASELPQPQPQPQALHYALANAQQVQIHQIGEDGQVQVIPQGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQVLQGAQLIAVASSDPAAAGVDGSPLQGSDIQVQYVQLAPVSDHTAGAQTAEALQPTLQPEMQLEHGAIQIQ
Protein: Uncharacterized protein C22E12.19 (Q10369)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Set3 complex subunit hif2
- SET domain-containing protein 3
- Histone deacetylase phd1
- Histone deacetylase clr6
- Transcriptional regulatory protein rxt3
- Paired amphipathic helix protein pst3
- Putative histone deacetylase complex subunit cti6
- RbAp48-related WD40 repeat-containing protein prw1
- SWIRM domain-containing protein laf1
- SWIRM domain-containing protein laf2
Sequence:
MDLTTPEVAEHPDVLRNMSRYTLGLLPSEPPVGDMNNEDSDTNTSITQSPTNSEKLTDILQESQDTKALQEKYLQNIYALTQNQLFKNVEDYSFYNLNREKFQRDKQTIVGVMRKRRHVLNKKIKRLQSHWKQVLGRWEENIARVDRLTEIDKTKNAKKSEPFIKRSTRKVMSNFTAGDIVRSEEEFLEILAKLEQQEKEASNVSEASRIATIPPMILSEEEVKSQYFNDQSRLVTDCPKFYHFQSMPDIWNEEQHSIFVQQFILHGKKFGKIAEAVPGKNSKECVLHYYLTKRTTDYRALVASATKTKGRRRKKLLPSQRGGKKKSKGSALMVDIEAADINKTEENINNQFQEASVTADNMNTWDNTPSVENVESANENVNNHNADEQMDEKIKSLVEGNSAYEIEKGAQEPDPMSIDMTDKSETVSGFKHDVDVYDTAENEGNNTLLQIKESVHEKTPTQDEPMDISQDTIKQEDYYEPKLEQHSSSKRNSISTRKEEDAASALANLSAVGRSISAVDESAHQGHLPGWDEKEEALIFSLAQGMNPMKMPLTPRRASTGPRPRPTFQLTEIDSPNRRRASDCITPSISKILKMVSEDAKSQRIDELSVEDQEHTTHSSHTTSDINAFPNSQSFPRASIHTLAALGEDIVERQSKNDKIV
Protein: GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) (P50141)
Organism: Gallus gallus (Chicken)
Function: May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P30793}. Nucleus {ECO:0000250|UniProtKB:P30793}.
Interaction partners:
- GTP cyclohydrolase 1 feedback regulatory protein
- 6-pyruvoyltetrahydropterin synthase.
- Nudix hydrolase 15.
- Inosine triphosphate pyrophosphatase
- Folylpolyglutamate synthase.
- Vacuolar protein sorting-associated protein VTA1 homolog
- Molybdenum cofactor synthesis 1.
- Alkaline phosphatase, tissue-nonspecific isozyme
- Alkaline phosphatase.
- Dihydrofolate reductase
Sequence:
MAAARSCNGYARREGPPSPKLGTEKPRVSAGSGGSGDGWRGERPRSEEDNELSLPSLAAAYTTILRALGEDPERQGLLKTPWRAATAMQFFTKGYQETIADVLNDAIFDEDHDEMVIVKNIDMFSLCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAIAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTATSTMLGVFREDPKTREEFLTLIRS
Protein: Ubiquitin carboxyl-terminal hydrolase nonstop (EC 3.4.19.12) (Deubiquitinating enzyme nonstop) (Ubiquitin thioesterase nonstop) (Ubiquitin-specific-processing protease nonstop) (Q9VVR1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of histone H2B, thereby acting as a coactivator in a large subset of genes. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SAGA-associated factor 11 homolog
- Transcriptional adapter 2b
- SAGA factor-like TAF6
- Transcriptional adapter 1-2
- SAGA-associated factor 29kDa
- Protein will decrease acetylation
- SAGA complex subunit Spt3
- Enhancer of yellow 2 transcription factor
- histone acetyltransferase
- Transcription-associated protein 1
Sequence:
MSETGCRHYQSYVKEHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGIQLYACLHCIYFGCRGAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIGWVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFYHKNVLEYE
Protein: Na/K/2Cl co-transporter (A9NJG3)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MSAPSSLPPAQGENPVPENEGLAVDTGLKPAGPTPSSSRFQVDLVAEAAGAADKTLASGDKGAPAPEGSEPAAGGEEAKGRFRVVNFVDPSGASPPEAVPAEGFQNGDTVMSEGSLHSSTGGQHHYHYDTHTNTYYLRTFGHNTIDAVPNIDFYRQTAAPLGDKLIRPTLSELHDELDKEPFEDGFANGDELTPAEEAAAKEASEPKGAVKFGWIKGVLVRCMLNIWGVMLFIRMSWIVGQAGIVLSCVIVLMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVELLVSVDCIMTDEINDIRIVGTITVILLLGISVAGMEWEAKAQIFLLVVLITAIFNYFIGSFIPLQSKESQGFFGYDSGIMMENMGPDFRGTESFFSVFAIFFPAATGILAGANISGDLSDPQLAIPRGTLLAILITGIVYLGVAISTGSCIVRDATGNDNDTHSAQIMANCTDAACKFGYDFSSCKSDNGLYNCRYGLQNDFQVMSIVSGFGPIITAGIFSATLSSALASLVSAPKVFQALCKDNIYPGLEMFAKGYGKNNEPLRGYILTFCIALAFILIAQLNVIAPIISNFFLASYALINFSVFHASLANSPGWRPSFKYYNMWVSLAGAVLCCVVMFVINWWAALMTDVIVLGLYIYVSYKKPDVNWGSSTQALTYHQALTHSLHLSSVEDHIKNFRPQCLVMTGYPNSRPALLHLVHAFTKNVGLMICGHVRTGSRRPNFKELSNDQTRYQRWLMKNETKAFYTPVFAEDIREGTQYLLQAAGLGRLRPNTLVIGFKNDWKDGDMMNVETYIQMIHDAFDYQYGAVVLRLKEGLDVSHISEQDDLLSSQEKTSGMKDVVVSIDMKDSDGDSSKPSSKATSVQNSPAIQKGDDDERKAATKPLLRKEKSPQMLNVADQRLLDASQLFKRKQGKGTVDVWWLFDDGGLTLLIPYLLTNKKKWNDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDINVLGDINTKPKKENVTAFEEMIEPYRLKEDDMEQDTAEALKASEPWRITDNELELYRAKTNRQIRLNELLKEHSSTANLIVMSMPLARKGAVSSALYMSWLETLSKDLPPLLLVRGNHQSVLTFYS
Protein: At1g06070 (AtbZIP transcription factor) (BZip transcription factor AtbZip69) (Basic-leucine zipper (BZIP) transcription factor family protein) (T21E18.12 protein) (Q9LNE0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDKEKSPAPPPSGGLPPPSGRYSAFSPNGSSFAMKAESSFPPLTPSGSNSSDANRFSHDISRMPDNPPKNLGHRRAHSEILTLPDDLSFDSDLGVVGAADGPSFSDDTDEDLLYMYLDMEKFNSSATSTSQMGEPSEPTWRNELASTSNLQSTPGSSSERPRIRHQHSQSMDGSTTIKPEMLMSGNEDVSGVDSKKAISAAKLSELALIDPKRAKRIWANRQSAARSKERKMRYIAELERKVQTLQTEATSLSAQLTLLQRDTNGLGVENNELKLRVQTMEQQVHLQDALNDALKEEVQHLKVLTGQGPSNGTSMNYGSFGSNQQFYPNNQSMHTILAAQQLQQLQIQSQKQQQQQQQHQQQQQQQQQQFHFQQQQLYQLQQQQRLQQQEQQSGASELRRPMPSPGQKESVTSPDRETPLTKD
Protein: Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (P41778)
Organism: Mus musculus (Mouse)
Function: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (By similarity). Binds the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (By similarity). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4. Acts as a transcriptional activator of PF4 in complex with MEIS1 (By similarity). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence. In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development. Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1). Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4 (By similarity). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression.
Subcellular location: Nucleus {ECO:0000269|PubMed:32190943}.
Interaction partners:
- Homeobox protein PKNOX1
- Homeobox protein Meis1
- Homeobox protein Hox-A9
- Homeobox protein Hox-B1
- Homeobox protein Meis2
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Homeobox protein Hox-A1
- Transcription factor E2-alpha
- Homeobox protein Hox-B5
Sequence:
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN
Protein: Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) (F1N339)
Organism: Bos taurus (Bovine)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR000929}.
Interaction partners:
- Growth factor receptor-bound protein 2
- SOS Ras/Rac guanine nucleotide exchange factor 1
- Receptor protein-tyrosine kinase
- Tyrosine-protein kinase
- Insulin receptor substrate 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Platelet-derived growth factor receptor beta
- Mast/stem cell growth factor receptor Kit
- Platelet endothelial cell adhesion molecule
- SOS Ras/Rho guanine nucleotide exchange factor 2
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDAKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLTDQASGDQSPLPPCTPTPSCAEMREDNARVYENVGLMQQQKSFR
Protein: PilV protein (Type 4 fimbrial biogenesis protein PilV) (Type 4a pilus minor pilin PilV) (Type IV pilus modification protein PilV) (Q57003)
Organism: Pseudomonas aeruginosa
Interaction partners:
Sequence:
MLLKSRHRSLHQSGFSMIEVLVALLLISIGVLGMIAMQGKTIQYTADSVERNKAAMLGSNLLESMRASPKALYDVKDQMATQSDFFKAKGSAFPTAPSSCTPLPDAIKDRLGCWAEQVKNELPGAGDLLKSDYYICRSSKPGDCDGKGSMLEIRLAWRGKQGACVNAADSSADTSLCYYTLRVEP
Protein: Endophilin B (FI09216p) (Q8T389)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNINLPNFNVKNLVKEAGSTISRVVQLTEEKLGTTERTEYDLHFQNLAERADVTKTWTEKIVRDTESVLIPNPQNRVEDFIFEKIEKSKPKRLSNLEHLALDMIEAGGDFGQDLPYGQALIKVGQAEQKLGQCEHDFIATSGICFTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSAERDLRVAQAEFDRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCGDVMEQLQRELANLGGPTPYIPLDVNEASASKSNISSGAAARGPGNNHSANMAATGHKPNQPMHVSTDQMQRARVLCSYDAKDHTELNLSANEVIFVTECSPVNEDYMYGKQGLLKGLVPRAFVEMLDEEHDVTL