wanglab/gogpt-training-data huggingface dataset:
Protein: Multiplexin, isoform H (E1JI49)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAMVISTRAKLVITALILFFLLGIVLVTGSTKGWFNPNRYNGERVAARIQDDGSIFYEGSGENILFEDSTEANILSDDFWNTGDEATDIFDASGMQPPGQTQYTHERPYRGIKGEKGERGPKGDSIRGPPGPPGPPGPKGETAPYPPFVETTSAGAKYTGECTCNASDILEAIKDNESLRESLRGAPGTPGKDGKPGTPGHTGATGVPGARGARGSEGAQGLKGEPGVDGLPGVMGPPGPPGPPGLPENYDESLMVNSMGAFRGTTQPGAKGVPGEKGDAGQKGERGDPGHKGAHGPSGAKGEPGEPGTPGLPGLPGQVGQPGGLDGLASANGTKGEKGEKGEKGMRGRRGGTGATGPIGPPGKPGPMGDIGHSGRPGMTGPKGEMGPKGPKGDSGGREGLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSGGVQYIPMPGPPGPPGPPGLPGLSISGPKGEPGVDSRSSFFGDASYYGRPEPPRQPGHSHKHEETLGLVDGEEPYFSASSSNMNMKIVPGAVTFQNIDEMTKKSALNPPGTLAYITEEEALLVRVNKGWQYIALGTLVPIATPAPPTTVAPSMRFDLQSKNLLNSPPPLLNTPTLRVAALNEPSTGDLQGIRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADRDLPVVNTRGDVLFNSWKGIFNGQGGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSMDTYCDAWHSGDHLKGSFASNLDGHKLLEQKRQSCDSKLIILCVEALSQDRKRKKREIGDGSSHGESESREFKTADEYAAHLENLLL
Protein: MIT domain-containing protein 1 (Q8WV92)
Organism: Homo sapiens (Human)
Function: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.
Subcellular location: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides.
Interaction partners:
- Charged multivesicular body protein 1a
- Charged multivesicular body protein 2a
- Vacuolar protein sorting-associated protein 4A
- IST1 homolog
- Charged multivesicular body protein 3
- RNF103-CHMP3 readthrough
Sequence:
MAKSGLRQDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDGKYHKQIKIEENATGFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGIEQVQQSRGLQEIEESLRSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKHTKNI
Protein: Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Glucosidase I) (A0A3B3IS52)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648, ECO:0000256|RuleBase:RU368089}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648, ECO:0000256|RuleBase:RU368089}.
Interaction partners:
Sequence:
MARGERRRRAVPAEGVRTAERAARGGPGRRDGRGGGPRSTAGGVALAVVVLSLALGMSGRWVLAWYRARRAVTLHSAPPVLPADSSSPAVAPDLFWGTYRPHVYFGMKTRSPKPLLTGLMWAQQGTTPGTPKLRHTYGKEVLLPEVGAKGQLKFISGHTSELGDFRFTLLPPTSPGDTAPKYGSYNVFWTSNPGLPLLTEMVKSRLNSWFQHRPPGAPPERYLGLPGSLKWEDRGPSGQGQGQFLIQQVTLKIPISIEFVFESGSAQAGGNQALPRLAGSLLTQALESHAEGFRERFEKTFQLKEKGLSSGEQVLGQAALSGLLGGIGYFYGQGLVLPDIGVEGSEQKVDPALFPPVPLFTAVPSRSFFPRGFLWDEGFHQLVVQRWDPSLTREALGHWLGLLNADGWIGREQILGDEARARVPPEFL
Protein: Uncharacterized SVF1-like protein YLR225C (Q05948)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MAVAIKKEKTKFAPVKEVLSEKDHANYTKFQDTSKLEWFCRTSNHKKFKSHSLLKAVRNPTETRIETQTLYFTDLTNGKCGLIQLLYSSVMGGIYKGFQLNFKIFKASSEENSEEDIDIWESFKIDNIKDFDTLKVESDNVTFHFVPLENSSSSGFAQLLIKIDIPKGSTSCLLKDLKVDITVNLQEGFIINPDGSNYYLDKSISLEELAKRDSSSTSRKMIRHVFVPRGFCNGTISYKKNDKPVKLDLKDTPMLYLDAVQGLIPNKAASKWNFLCFNGEKRSMMCIEFTTTKEYGSTTVTIWAVSDKDKILEVGSSVNDHAVKFPSTKEDKQNGWKYPTSISFPRGFEESNLRLVNRYDIMSELPAFIRSIAENLANMKPFIYQFCQKSKFDDDEGVSIIESTFIN
Protein: UDP-glycosyltransferase 72B2 (EC 2.4.1.-) (Q8W4C2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative pectinesterase
- Glutaredoxin family protein
- non-specific serine/threonine protein kinase
- Cytochrome P450 71B22
- Probable acyl-activating enzyme 12, peroxisomal
Sequence:
MAEANTPHIAIMPSPGMGHLIPFVELAKRLVQHDCFTVTMIISGETSPSKAQRSVLNSLPSSIASVFLPPADLSDVPSTARIETRAMLTMTRSNPALRELFGSLSTKKSLPAVLVVDMFGADAFDVAVDFHVSPYIFYASNANVLSFFLHLPKLDKTVSCEFRYLTEPLKIPGCVPITGKDFLDTVQDRNDDAYKLLLHNTKRYKEAKGILVNSFVDLESNAIKALQEPAPDKPTVYPIGPLVNTSSSNVNLEDKFGCLSWLDNQPFGSVLYISFGSGGTLTCEQFNELAIGLAESGKRFIWVIRSPSEIVSSSYFNPHSETDPFSFLPIGFLDRTKEKGLVVPSWAPQVQILAHPSTCGFLTHCGWNSTLESIVNGVPLIAWPLFAEQKMNTLLLVEDVGAALRIHAGEDGIVRREEVVRVVKALMEGEEGKAIGNKVKELKEGVVRVLGDDGLSSKSFGEVLLKWKTHQRDINQETSH
Protein: Large ribosomal subunit protein eL32 (60S ribosomal protein L32) (P62912)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62910}.
Interaction partners:
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein eL13
- Ubiquitin-like protein FUBI
Sequence:
MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNPNARLRSEENE
Protein: Ferruginol synthase (EC 1.14.14.175) (Cytochrome P450 76AH30) (A0A1Z3GBS4)
Organism: Isodon rubescens (Rabdosia rubescens)
Function: Cytochrome P450 enzyme (CYP) which catalyzes a unique two-electron oxidation cascade on abieta-8,11,13-triene to produce ferruginol, an intermediate in tanshinone biosynthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
METIALLAALFFIALTCFLTSGRRRNLPPGPYPLPIIGNMLQLGSNPHQSFAQLSKKYGPLMSIHLGSLYTVIVSSPEMAKEILHKHGQAFSGRTIAQAVHACDHDKISMGFLPVTSVWRDLRKICKEQMFSHQSLEASEGLRHQKLQQLLDYAQKCCETGRAVDIREASFITTLNLMSATMFSTQATEFESEATKEFKEIIEGVATIVGVPNFADYFPILKPFDLQGIKRQADGYFGRLLKKIEGYLNERVESRRLNPDAPRKNDFLETVVDIIEADEYKLTTDHLTHLMLDLFVGGSETNTTSLEWIMSELVINPDKMAKVKDEIKSVVGDKKIVDESEMPRLPYLQAAIKEVLRIHPPGPLLLPRRAEIDQEVNGYLIPKGTQILFNAWAIGRDPSIWKNPESFEPERFLDQTVDFKGQDFELIPFGSGRRICPGMPLANRILHMTTATLVHNFDWKLEEETANADHQDELFGLAVRRAVPLKIIPLRP
Protein: Fatty acid desaturase (Q9U972)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPPNAQAGAQSISDSLIAAASAAADAGQSPTKLQEDSTGVLFESDVETTDGGLVKDITVMKKAEKRRLKLVWRNIIVFGYFHLAALYGAYLMVTSAKWQTCILAYFLYVISGLGITAGAHRLWAHRSYKAKWPLRVILVIFNTIAFQDAAYHWARDHRVHHKYSETDADPHNATRGFFFSHVGWLLCKKHPEVKAKGKGVDLSDLRADPILMFQKKYYMILMPIACFIIPTVVPMYAWGESFMNAWFVATMFRWCFILNVTWLVNSAAHKFGGRPYDKFINPSENISVAILAFGEGWHNYHHVFPWDYKTAEFGKYSLNFTTAFIDFFAKIGWAYDLKTVSTDIIKKRVKRTGDGTHATWGWGDVDQPKEEIEDAVITHKKSE
Protein: Granulocyte colony-stimulating factor (A0A8I6AAV9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKLMALQLLLWHSALWSGQEAIPLLTVSSLPPSLPLPRSFLLKSLEQVRKIQARNTELLEQLCATYKLCHPEELVLFGHSLGIPKASLSSCSSQALQQTKCLSQLHSGLFLYQGLLQALAGISSELAPTLDMLHLDVDNFATTIWQQMESLGVAPTVQPTQSTMPIFTSAFQRRAGGVLVTSYLQSFLETAHHHFPESLFISI
Protein: Arrestin C-terminal-like domain-containing protein (I2HAB8)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MFIANNCMPQFRWEDMPTTQINIVLAEPRCMAGEFFNAKVLLDSSDPDTVVHSFCAEIKGIGRTGWVNIHTDKIFETEKTYIDTQVQLCDSGTCLPVGKHQFPVQIRIPLNCPSSYESQFGSIRYQMKVELRASTDQASCSEVFPLVILTRSFFDDVPLNAMSPIDFKDEVDFTCCTLPFGCVSLNMSLTRTAFRIGESIEAVVTINNRTRKGLKEVALQLIMKTQFEARSRYEHVNEKKLAEQLIEMVPLGAVKSRCRMEFEKCLLRIPDAAPPTQNYNRGAGESSIIAIHYVLKLTALPGIECEIPLIVTSCGYMDPHKQAAFQHHLNRSKAKVSKTEQQQRKTRNIVEENPYFR
Protein: Uracil nucleotide/cysteinyl leukotriene receptor (UDP/CysLT receptor) (G-protein coupled receptor 17) (Q09QM4)
Organism: Rattus norvegicus (Rat)
Function: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Subcellular location: Cell membrane; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDGLETALPSLTDNASLAYSEQCGQETPLENMLFACFYLLDFILAFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIPCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRSLRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCSAQRALALGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLSARSEL
Protein: Putative uncharacterized protein YNL226W (P53864)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MLFPGGQTVLHKRLESQQIFVWLLQHYLGFYLGDIVGPFYGKLFLTQDQKHAFRPLKAHSSRSSSVIFEVVGYHYTDINSWLVRLLLCKKSYFAMTSNFFHVYFFSILKTRKSVNIKCWPLKPSNFTTNEYFIHTS
Protein: Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) (Q969V6)
Organism: Homo sapiens (Human)
Function: Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24440334}. Nucleus {ECO:0000269|PubMed:19350017, ECO:0000269|PubMed:24440334}. Note=Subcellular location is tightly regulated by actin both in cytoplasm and nucleus: high levels of G-actin in the nucleus observed during serum deprivation lead to low levels of nuclear MRTFA, while reduced levels of nuclear G-actin result in accumulation of MRTFA in the nucleus (By similarity). G-actin-binding in the cytoplasm inhibits nuclear import by masking the nuclear localization signal (NLS) (By similarity). In contrast, binding to nuclear globular actin (G-actin) promotes nuclear export to the cytoplasm (By similarity). Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear actin, which decreases nuclear G-actin pool, thereby promoting retention of MRTFA in the nucleus and subsequent formation of an active complex with SRF (PubMed:24440334). Nuclear import is mediated by importins KPNA4 and KPNB1 (By similarity). {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:24440334}.
Interaction partners:
- Serum response factor
- Hydroxyacid-oxoacid transhydrogenase, mitochondrial
- RNA-binding protein 15
- Actin, alpha skeletal muscle
- Phosphatase and actin regulator 1
- Transforming protein RhoA
- Hydroxysteroid dehydrogenase-like protein 2
- Sorbitol dehydrogenase
- 2-hydroxyacyl-CoA lyase 2
- 2-hydroxyacyl-CoA lyase 1
Sequence:
MPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFLAEQPPLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEALGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVVAFPAARLSTGPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRMLRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAPAPSAQMDLEHPLQPLFGTPTSLLKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILIQSGEISADFKEPPSLPGKEKPSPKTVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGRLEDFLESSTGLPLLTSGHDGPEPLSLIDDLHSQMLSSTAILDHPPSPMDTSELHFVPEPSSTMGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL
Protein: Mitochondrial import inner membrane translocase subunit tim16 (Presequence translocated-associated motor subunit pam16) (Q9C1W5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (ssc1) via its interaction with PAM18/TIM14. May act by positioning pam18/tim14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit tim14
- Mitochondrial import inner membrane translocase subunit tim44
- Mitochondrial import inner membrane translocase subunit tim17
- Mitochondrial import inner membrane translocase subunit tim23
- Mitochondrial import inner membrane translocase subunit tim50
- GrpE protein homolog
- Protein mgr2
- Mitochondrial import inner membrane translocase subunit tim21
- Mitochondrial import inner membrane translocase subunit tim9
- Presequence translocated-associated motor subunit pam17
Sequence:
MSLPRAVGRFIIVGSQVMSKAFVQAYKQMIANAAQQSTGQAAASKSSTAVRRGEMTIQEAGSILNIKPESLEEGELEKRFQKMFEINDPKKGGSFYLQSKVFRAHEKLKSELDQKIQEQSPAKPTSSP
Protein: EH domain-containing protein 4 (PAST homolog 2) (mPAST2) (Q9EQP2)
Organism: Mus musculus (Mouse)
Function: ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.
Subcellular location: Early endosome membrane {ECO:0000250|UniProtKB:Q9H223}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9H223}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:21177873}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:33972531}.
Interaction partners:
- Rabenosyn-5
Sequence:
MFSWMGRQAGGRERSGGMDAVQTVTGGLRSLYQRKVLPLEEAYRFHEFHSPALEDADFENKPMILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISIIDSPGILSGEKQRISRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKEMPNMFGKENKKRELIYRLPEIYVQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLKPKLIEAVDNMLTNKISSLMGLISQEEMNMPTQMVQGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEEEFALAKHLIKIKLDGYELPNSLPPHLVPPSHRKSLPKAD
Protein: Enhancer of rudimentary homolog 2 (Q20057)
Organism: Caenorhabditis elegans
Function: Required for chromosome segregation and cell division in early embryos. Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively. Within the tost-1 variant of the PETISCO complex binds to splice leader SL1 RNA fragments to possibly play a role in their processing. Promotes the biogenesis of 21U-RNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:31147388, ECO:0000269|PubMed:31216475}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:31147388, ECO:0000269|PubMed:31216475}. Nucleus {ECO:0000269|PubMed:31216475}. Note=Dispersedly distributes throughout the cytoplasm in early embryos (PubMed:31147388). During early embryogenesis, localizes to the nucleus at prophase of cell division, and remains in the cytosol at interphase in 2- and 4-cell embryos (PubMed:31216475). Localizes to puncta in the perinuclear region in the germline syncytium (PubMed:31147388, PubMed:31216475). {ECO:0000269|PubMed:31147388, ECO:0000269|PubMed:31216475}.
Interaction partners:
- Protein pid-3
- Protein tost-1
- Embryonic developmental protein tofu-6
- Eukaryotic translation initiation factor 4E-3
- Protein pid-1
- Schlafen-like protein 2
- Schlafen-like protein 1
- K Homology domain-containing protein
- piRNA biogenesis factor prde-1
- Twenty One u-rna
Sequence:
MSTSSHTVLLIQTSPRLDSRTWGDYESVTDALDALCKMFEDFLSKKSAAPVTYDVSQVYEFLDKLSDVSMMIFNRETGQYIGRTRAWIKQQVYEMMRGRCQHPEGGEKVIVGY
Protein: MYB transcription factor (Myb domain protein 19) (Similarity to myb-related transcription factor) (Q9LTJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- MATH domain and coiled-coil domain-containing protein At3g44800
Sequence:
MTKSGERPKQRQRKGLWSPEEDQKLKSFILSRGHACWTTVPILAGLQRNGKSCRLRWINYLRPGLKRGSFSEEEEETILTLHSSLGNKWSRIAKYLPGRTDNEIKNYWHSYLKKRWLKSQPQLKSQISDLTESPSSLLSCGKRNLETETLDHVISFQKFSENPTSSPSKESNNNMIMNNSNNLPKLFFSEWISSSNPHIDYSSAFTDSKHINETQDQINEEEVMMINNNNYSSLEDVMLRTDFLQPDHEYANYYSSGDFFINSDQNYV
Protein: 3'3'-cGAMP-specific phosphodiesterase 2 (3'3'-cGAMP PDE 2) (V-cGAP2) (EC 3.1.4.-) (Q9KMV8)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: Phosphodiesterase (PDE) that catalyzes the hydrolysis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP), leading to linear 5'-pApG. Counteracts the function of the 3'3'-cGAMP synthase DncV, and is involved in the modulation of intracellular 3'3'-cGAMP levels. Enhances bacterial chemotaxis and inhibits intestinal colonization in vivo. Thus exerts a crucial role in regulating bacterial infectivity through catalyzing 3'3'-cGAMP degradation. Is specific for 3'3'-cGAMP since it cannot degrade other cGAMP linkage isomers (3'2'-, 2'3'-, and 2'2'-cGAMPs). Is also able to hydrolyze c-di-GMP but not c-di-AMP.
Interaction partners:
- histidine kinase
- diguanylate cyclase
- Aerobic respiration control sensor protein
- GGDEF family protein
- histidine kinase
- histidine kinase
- histidine kinase
- Response regulator
- histidine kinase
- GGDEF family protein
Sequence:
MKWFKYGDGMDLFADMRQEAAGEKERVVMHSQEPWCVLLVDDDEQMHQITRLALTGFKFQNRPLELISVLSGLEARKVMAERSDIALALVDVVMETEHAGLDLVRYIREELQNRQVRLVLRTGQAGQAPEDRVIKEYEIDDYKEKTELTTQKLRTLLYSMLRAYRDLCLIEDQKLGLSHVIEASANVQNTKSLQSYATAVLNQLTSLLKLHASAFYCVATPCPDSEKCNALTVATTAERVELYVESPFKGLPEDVQRRCKEVLSQRTTRDYGDAYVFFKQDERGVDSVLYVGFEQELSELDRKLLEIYMYNIGLTFENINLMVDLRETSKELVYNLANAVEARSRETGAHVQRVALYCERLAHLYGLAESEADMIKNASPLHDVGKVAIPDSILHKPGKLDAQEWAIMQKHVEYGVEILNRSKRRLMQVAKEIAATHHEKWDGSGYPNRLQGDDIPISGRITAIADVFDALGAKRSYKDPWTDEQIREELMAQKGRHFEPKLVELLLEHWDEFIAIRASLPD
Protein: Uncoating factor OPG117 (EC 3.6.4.-) (P04305)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Multifunctional protein required for genome uncoating and replication. Major viral uncoating protein that is required for the release of the viral genome from incoming viral cores containing the viral DNA genome. Possesses an ATPase activity that is required for hexamerization and uncoating.
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:24439902}. Note=Colocalizes with free cytoplasmic cores containing the viral DNA genome. {ECO:0000269|PubMed:24439902}.
Interaction partners:
Sequence:
MDAAIRGNDVIFVLKTIGVPSACRQNEDPRFVEAFKCDELERYIENNPECTLFESLRDEEAYSIVRIFMDVDLDACLDEIDYLTAIQDFIIEVSNCVARFAFTECGAIHENVIKSMRSNFSLTKSTNRDKTSFHIIFLDTYTTMDTLIAMKRTLLELSRSSENPLTRSIDTAVYRRKTTLRVVGTRKNPNCDTIHVMQPPHDNIEDYLFTYVDMNNNSYYFSLQQRLEDLVPDKLWEPGFISFEDAIKRVSKIFINSIINFNDLDENNFTTVPLVIDYVTPCALCKKRSHKHPHQLSLENGAIRIYKTGNPHSCKVKIVPLDGNKLFNIAQRILDTNSVLLTERGDHIVWINNSWKFNSEEPLITKLILSIRHQLPKEYSSELLCPRKRKTVEANIRDMLVDSVETDTYPDKLPFKNGVLDLVDGMFYSGDDAKKYTCTVSTGFKFDDTKFVEDSPEMEELMNIINDIQPLTDENKKNRELYEKTLSSCLCGATKGCLTFFFGETATGKSTTKRLLKSAIGDLFVETGQTILTDVLDKGPNPFIANMHLKRSVFCSELPDFACSGSKKIRSDNIKKLTEPCVIGRPCFSNKINNRNHATIIIDTNYKPVFDRIDNALMRRIAVVRFRTHFSQPSGREAAENNDAYDKVKLLDEGLDGKIQNNRYRFAFLYLLVKWYRKYHVPIMKLYPTPEEIPDFAFYLKIGTLLVSSSVKHIPLMTDLSKKGYILYDNVVTLPLTTFQQKISKYFNSRLFGHDIESFINRHKKFANVSDEYLQYIFIEDISSP
Protein: Adducin-related protein 1 (Q9U9K0)
Organism: Caenorhabditis elegans
Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Actin
- Uncharacterized sugar kinase R08D7.7
- Methylthioribose-1-phosphate isomerase
- Triosephosphate isomerase
- Uncharacterized protein
- transketolase
- AO66 ankyrin
- Adducin-related protein 2
- Fructose-1,6-bisphosphatase isozyme 2
- 6-phosphogluconate dehydrogenase, decarboxylating
Sequence:
MIGRKEKERERPYYRDPDDPEYIKDLQRPAVIKEDLSEMERRKRVQQILESKSFCHELEEVIRQECDTARTDPDHLQVLQKLSDLTVPQGNMSFGNLHTYGGNTIAIADLRGNEKYSKAERIQRNKLACLFRLADLFQWSQGIHNEISYRTNDEDNTFLMNPFGLLYHEITAATIVKIDENGKILDCGTLKAGVNQPAFLLHSAIYKAHPMVRCILHMHTAIVAAVASMKCGLLPLCKEAMVLGPVGYHDYQDIGDDDIQFDEIIANLGDKNVLFLRNQGFLVVGDTIEHATFLANNTVIACETQVRAARAGLDNLIIPEEKAIQRAFRNSRNTNSLKRNGTVDWRVGELEWESWMRVLDHANFQTGHVYRQPQLRPKSAMSTSMVNNNDVAVPPTTSAYGQIDETNLESVSAHRLALLRKEQERVRWMNSPNAYQKVEFLEYGADNPKKITKWVHDVNVPSASGTPVKISSVHQFSPASSNPKEFKEKQKAIKENNRLGTLSAGPQSQILDSVTYEDIALLIKPDNDGTVGQSSTADRAILIGTASKGIIDRQFQHHAQVYHQIYAPNPFSVETDADIKKYVDMVKAKNSQSAPVSARSGYSQYDEVEADTVSLMQGVREHKLSQAALSASDDGLNAGISPNNVRTSEESVNTSYMSQSVVFDCDHPSPMSISTEYPEKVKMTRFSSTQGTSEGNTTSRSCTTASEEEKPTKDEKKKKKKGFLSFMRKKDK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9VBU2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein LTV1 homolog
- Pre-rRNA-processing protein TSR1 homolog
- RNA-binding protein NOB1
- Bystin
- KRR1 small subunit processome component homolog
- Small ribosomal subunit protein uS3
- 40S ribosomal protein S15
- Small ribosomal subunit protein uS10
- Probable dimethyladenosine transferase-N
- RRP12-like protein
Sequence:
MGKLNVTVLRYLTKEDFRVLTAIEMGMKNHELVPGPLAAAIANLKSGGVHKLLKELCKHKLLAYERGKKYDGYRLTNTGYDYLALKSLTLRGSVSSFGNQIGIGKESNIYVVADEEGTPICLKLHRLGRTCFRNVKAKRDYHGRRHKASWLYLSRISATREFAYMSALYDRGFPVPKPIDFNRHCVLMDLVKGWPMTQVHELLDAPQVYDDLMNLIVRLGNSGVIHGDFNEFNLMVTDAGKPILIDFPQMMSTSHENAEFFFERDVNCVREMFRRKFGYESEDYPKFSDLVREDDLDAEVHCTGYGFTKEMEQDLLEEYGMVDQADEEDEGEDLEEEEEPPTLVTAASVEIDECRRQVENEVIYSEAKPTQKSDDAVRRYIESCTQYLGNLSVGPEVPDQTMPKKLDISLPAETPDVIPFEAETSATNTVEEDVKSISSNDLDTDEVPELVGLDPNSRMYRLKMVEQMLNDARSQRSYSTTTSTIAPSVITDRIRRNMDIKEKREQRKKCVAKGEASAVHRHRKENKDVVKEYAGWDF
Protein: Major prion protein (A2A2V1)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIF