wanglab/gogpt-training-data huggingface dataset:
Protein: Prostaglandin E synthase (EC 2.5.1.18) (EC 5.3.99.3) (Glutathione peroxidase PTGES) (Glutathione transferase PTGES) (Microsomal prostaglandin E synthase 1) (Q2TJZ7)
Organism: Sus scrofa (Pig)
Subcellular location: Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Prostaglandin E synthase 2
- Prostaglandin E synthase 3
- Prostaglandin G/H synthase 2
- Prostaglandin G/H synthase 1
- Prostaglandin-H2 D-isomerase
- Hematopoietic prostaglandin D synthase
- Prostacyclin synthase
- Uncharacterized protein
- Carbonyl reductase 1])
- Thromboxane-A synthase
Sequence:
MPPPSLEMVSGQVLPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDAQRHGGLQYCRSDPDVERCLRAHRNDMETIYPFLFLGLVYSFLGPDPFVAWMHFLIFFLGRMVHTIAYLGKLRAPTRSLAYTLAQLPCASMALQIVWEAARHL
Protein: Ras guanine nucleotide exchange factor Q (RasGEF domain-containing protein Q) (Q86G47)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis.
Interaction partners:
- Ras-like protein rasB
- Ras-like protein rasG
Sequence:
MDINNNIDNITNSNNNIEKNNNINNFDNNNNNNNILYISSSESNNNNNINSSNSSSNNTNNSNNSSISNNNNNNNNNNNNNNNISIEGNTANNSDIKVGTSLTNSIKSFKKLFNNQKSNNNNNNLQVNHFQQSQSLPPSSNTSPTFSSTSPIIIVSDNTNIESLDLEINSNNSGSIGSNNSGDNNNINMNYKSKSLSLNYSILRPLCDTDNISNNNNNNNNNSNNSNNNNNMSSSDNNNNSNSNNTTNGGQLKRNNSSNNNNRYSIGGPLKMSNSSDFNDYLLNNNILYNINQPNRKTPPPNLMSVLKNSFTQYTPPSTTLTSPTSTRNPNRLSTNLSNVTNISSSTSSSSSSLNANNNTNNNNQQLQQQQQQQQQQQLQQQQQLTKSYSVSNLMRSQSSSSSSQSPLIQQSDQVTFDYDYIYRRFLRSRSELTLPSWDNAQYEGDFDTEIQDTLTRALSNGNLPSDNKRQSLHLSTESTTSNNNNNNNNNNNNNNNNNNNKSKTDDTTNSATTTTTTTTTTTTTTTTNSTTTTTQLNNGKNLIGLVYNDKDEVIAGERDKIIGLFTDISKVTGTQFLEEFLFTYHYYMTSVDLLENLKGRFNNPLMDQAAQSISILEENHDKVKIEQLSTHIRLRVINVIKKWIENHGYAFATDINLYQMLVDFIDGDVMSFSQRWGQYLKKAINDSGCLLRYIAVNVKEASSKQLREIISLDNLDAISKLMSQSLQLKERKKGLKVIKNSFTGNEAVEWLINKFNLDSKDEALETLSKMLQSNLIFHHSKSGSSFSPSSSSSSTTTTTTTSSSSSSSNTTTANMASSSSATDNSSSGGVVTSSSSSSSSSSSSPSNGNGTTAITSTSLPNSISSSNSTSILTSLVVNSNSSGIANGSSTPSIPSSVTSPLTNSKSTLNSTPSSSSNSFTFKDKSTSIYYFIFENINFPEPIVPKTFFSSPNSTFSITFLDIHPVEIARQLTLIDYELFKKLSPTDFYHTAWSKPDAKEKVPNLINFINRSNTVSYWVATEILSSSNIKHRVSVLKRFITIAEILRKFHNWNTLTGILMGLNLGSIQRLKKTWESIDKKQLDSLQNLINLTSERLNYSNYRKEMSTPTYPCLPFMAVYLKDLYFIEENPDYLENGYINFEKMKMISKVLIEIKRYQTEQYWLKKIDAIENILKSVVLTDKDLYKASHMIEQPQRTMTVGSNLKAQSFLTTTTTTTTTNNLNNNNNNNNPNNNNNNNNNSANNKSSPSPSPSSSPITSSPISSLTINNNNTISSNLSASTDSSINTKKKSSFLMFGKK
Protein: Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (Helicase of 117.4 kDa) (Q62780)
Organism: Rattus norvegicus (Rat)
Function: Plays an essential role in splicing, either prior to, or during A complex formation.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q7L014}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q7L014}. Note=Present in Cajal bodies (CBs) and nuclear speckles. {ECO:0000250|UniProtKB:Q7L014}.
Interaction partners:
- PHD finger-like domain-containing protein 5A
- Splicing factor 3B subunit 1
- Splicing factor 3A subunit 1
- Splicing factor 3A subunit 2
- Splicing factor 3a, subunit 3
- Small nuclear ribonucleoprotein Sm D1
- Splicing factor 3B subunit 5
- Splicing factor 1
- Small nuclear ribonucleoprotein polypeptide A'
- Splicing factor 3b, subunit 2
Sequence:
MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGSKSKKAENRSRSKEKAEGGDSSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEDEELDPLDAYMEEVKEEVKKFNMRSVKGGAGNEKKSGPTVTKVVTVVTTKKAVVDADKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSAPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGPLLAPTVSAKTIAEQLAEKINAKLNYVPLEKQEEERQEGGQSESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSYQPTNKGRYKVL
Protein: LRR receptor-like serine/threonine-protein kinase FEI 2 (EC 2.7.11.1) (C0LGL9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the signaling pathway that regulates cell wall function, including cellulose biosynthesis, likely via an 1-aminocyclopropane-1-carboxylic acid (ACC)-mediated signal (a precursor of ethylene).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19017745}; Single-pass type I membrane protein {ECO:0000269|PubMed:19017745}.
Interaction partners:
- Fasciclin-like arabinogalactan protein 4
- Hydroxyproline O-galactosyltransferase GALT5
- Hydroxyproline O-galactosyltransferase GALT2
- Cellulose synthase A catalytic subunit 5
- Protein MID1-COMPLEMENTING ACTIVITY 1
- Probable pectate lyase 13
- COBRA-like protein 2
- Hydroxyproline O-galactosyltransferase GALT6
- Hydroxyproline O-galactosyltransferase GALT3
- Cellulose synthase A catalytic subunit 6
Sequence:
MGICLMKRCCSWFLLISFLSALTNENEAISPDGEALLSFRNGVLASDGVIGLWRPEDPDPCNWKGVTCDAKTKRVIALSLTYHKLRGPLPPELGKLDQLRLLMLHNNALYQSIPASLGNCTALEGIYLQNNYITGTIPSEIGNLSGLKNLDLSNNNLNGAIPASLGQLKRLTKFNVSNNFLVGKIPSDGLLARLSRDSFNGNRNLCGKQIDIVCNDSGNSTASGSPTGQGGNNPKRLLISASATVGGLLLVALMCFWGCFLYKKLGRVESKSLVIDVGGGASIVMFHGDLPYASKDIIKKLESLNEEHIIGCGGFGTVYKLSMDDGNVFALKRIVKLNEGFDRFFERELEILGSIKHRYLVNLRGYCNSPTSKLLLYDYLPGGSLDEALHKRGEQLDWDSRVNIIIGAAKGLAYLHHDCSPRIIHRDIKSSNILLDGNLEARVSDFGLAKLLEDEESHITTIVAGTFGYLAPEYMQSGRATEKTDVYSFGVLVLEVLSGKLPTDASFIEKGFNIVGWLNFLISENRAKEIVDLSCEGVERESLDALLSIATKCVSSSPDERPTMHRVVQLLESEVMTPCPSDFYDSSSD
Protein: Serine/threonine-protein kinase chk-2 (EC 2.7.11.1) (Ce-cds-1) (Ce-chk-2) (Q9U1Y5)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase.
Subcellular location: Nucleus {ECO:0000269|PubMed:11086161, ECO:0000269|PubMed:11158318}.
Interaction partners:
- Protein hsr-9
- Serine/threonine-protein kinase ATR
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase ATM
- DNA repair protein RAD51 homolog
- Exonuclease 1
- Checkpoint protein
- Sun domain-containing protein 1
- Meiotic recombination protein spo-11
- C2H2-type domain-containing protein
Sequence:
MVRGTKRRRSSAEKPIVVVPVTRDDTMPVDEDLVVGESQCAASKPFAKLVGVRRGISSIDLADDHFVCGRGSDDAPTNFNFSQVAKDVGLYRFISKIQFSIDRDTETRRIYLHDHSRNGTLVNQEMIGKGLSRELMNGDLISIGIPALIIFVYESADADHHPEELTKKYHVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVMKKLSHPNIVAIYDWITVAKYSYMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMAKNSVNRMKTRCGTPSYNAPEIVANEGVEYTPKVDIWSLGCVLFITFSGYPPFSEEYTDMTMDEQVLTGRLIFHAQWRRITVETQNMIKWMLTVEPSNRPSAVELMSTQWMKCADCRTAKQDILKSIKPISAAAPAALQTTQAGPVKKAKM
Protein: Transcriptional regulator, MarR family, putative (O53397)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MGKGAAFDECACYTTRRAARQLGQAYDRALRPSGLTNTQFSTLAVISLSEGSAGIDLTMSELAARIGVERTTLTRNLEVMRRDGLVRVMAGADARCKRIELTAKGRAALQKAVPLWRGVQAEVTASVGDWPRVRRDIANLGQAAEACR
Protein: DNA topoisomerase 4 subunit B (EC 5.6.2.2) (Topoisomerase IV subunit B) (P20083)
Organism: Escherichia coli (strain K12)
Function: Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes. It relaxes supercoiled DNA. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.
Interaction partners:
- DNA gyrase subunit A
- DNA topoisomerase 4 subunit A
- mRNA interferase toxin RelE
- Antitoxin RelB
- Endoribonuclease toxin MazF
- Toxin YoeB
- Antitoxin YefM
- 1,2-phenylacetyl-CoA epoxidase, subunit A
- mRNA interferase toxin HigB
- Serine/threonine-protein kinase toxin HipA
Sequence:
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVNVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDETFFDSPRFSVSRLTHVLKAKAVLCPGVEITFKDEINNTEQRWCYQDGLNDYLAEAVNGLPTLPEKPFIGNFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFILWLNQNVQAAELLAEMAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHIATLLCALFVKHFRALVKHGHVYVALPPLYRIDLGKEVYYALTEEEKEGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTIDDEDDQRTDAMMDMLLAKKRSEDRRNWLQEKGDMAEIEV
Protein: V-set and immunoglobulin domain-containing protein 8 (P0DPA2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRVGGAFHLLLVCLSPALLSAVRINGDGQEVLYLAEGDNVRLGCPYVLDPEDYGPNGLDIEWMQVNSDPAHHRENVFLSYQDKRINHGSLPHLQQRVRFAASDPSQYDASINLMNLQVSDTATYECRVKKTTMATRKVIVTVQARPAVPMCWTEGHMTYGNDVVLKCYASGGSQPLSYKWAKISGHHYPYRAGSYTSQHSYHSELSYQESFHSSINQGLNNGDLVLKDISRADDGLYQCTVANNVGYSVCVVEVKVSDSRRIGVIIGIVLGSLLALGCLAVGIWGLVCCCCGGSGAGGARGAFGYGNGGGVGGGACGDLASEIREDAVAPGCKASGRGSRVTHLLGYPTQNVSRSLRRKYAPPPCGGPEDVALAPCTAAAACEAGPSPVYVKVKSAEPADCAEGPVQCKNGLLV
Protein: Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) (Q9Z0Y9)
Organism: Mus musculus (Mouse)
Function: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis. Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:27383786}. Cytoplasm {ECO:0000269|PubMed:27383786}.
Interaction partners:
- Retinoic acid receptor RXR-alpha
- Retinoic acid receptor RXR-beta
- Nuclear receptor corepressor 1
- Nuclear receptor coactivator 1
- Nuclear receptor corepressor 2
- Oxysterols receptor LXR-beta
- Nuclear receptor subfamily 0 group B member 2
- Proteasome activator complex subunit 3
- Phospholipid-transporting ATPase ABCA1
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Sequence:
MSLWLEASMPDVSPDSATELWKTEPQDAGDQGGNTCILREEARMPQSTGVALGIGLESAEPTALLPRAETLPEPTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAQATSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDPLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Protein: B3 domain-containing transcription factor LEC2 (Protein LEAFY COTYLEDON 2) (Q1PFR7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription regulator that plays a central role in embryo development. Required for the maintenance of suspensor morphology, specification of cotyledon identity, progression through the maturation phase and suppression of premature germination. Ectopic expression is sufficient to promote somatic embryogenesis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Nuclear transcription factor Y subunit B-9
- Agamous-like MADS-box protein AGL15
- Nuclear transcription factor Y subunit B-6
- Ethylene-responsive transcription factor WRI1
- Protein WUSCHEL
- CHD3-type chromatin-remodeling factor PICKLE
- Transcription factor MYB118
- Trihelix transcription factor ASIL1
- Floral homeotic protein APETALA 2
- Diacylglycerol O-acyltransferase 1
Sequence:
MDNFLPFPSSNANSVQELSMDPNNNRSHFTTVPTYDHHQAQPHHFLPPFSYPVEQMAAVMNPQPVYLSECYPQIPVTQTGSEFGSLVGNPCLWQERGGFLDPRMTKMARINRKNAMMRSRNNSSPNSSPSELVDSKRQLMMLNLKNNVQISDKKDSYQQSTFDNKKLRVLCEKELKNSDVGSLGRIVLPKRDAEANLPKLSDKEGIVVQMRDVFSMQSWSFKYKFWSNNKSRMYVLENTGEFVKQNGAEIGDFLTIYEDESKNLYFAMNGNSGKQNEGRENESRERNHYEEAMLDYIPRDEEEASIAMLIGNLNDHYPIPNDLMDLTTDLQHHQATSSSMPPEDHAYVGSSDDQVSFNDFEWW
Protein: Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2) (Q8BNJ6)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Glutamate receptor ionotropic, kainate 2
- Solute carrier family 12 member 5
- Lysine--tRNA ligase
- Glutamate receptor ionotropic, kainate 1
- Glutamate receptor ionotropic, kainate 4
Sequence:
MALEQLCAVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDERYYIEPSFECRFDHLEIRDGPFGFSPLIDRYCGMKSPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSAIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLFTSFVEPPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGLFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLREKEISADLADLSEELDNYQKLRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQAHECPEQALEDRVMEEIPCEIYVRGRDDSAQASISIDF
Protein: PPPDE domain-containing protein (Q382J0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEQGQPATPFAGLASGVAATVTNILGRLDIGGNDRKVRSDLPPNTVFLNVYDITVANRILYYTGAGVHHTGVELYGMEFAFGRCEEDTGVFQVEPKNTPPHTFREQLVLGTTQLTRGEVLGLVQEMKGNRERWSGRSYHIVKNNCNSFSEAFAKRLLPPDVRYDQHQAREKKDGSSSVVEVYDNGEREVVRLSGGQSVEVPVLMPSWVNRLANTAERILGEDLVQKIDDIDRKAVR
Protein: Leupeptin-inactivating enzyme 1 (LIE1) (EC 3.4.24.-) (P81715)
Organism: Streptomyces exfoliatus (Streptomyces hydrogenans)
Function: A leucine-specific metalloprotease that plays a role in controlling the amount of leupeptin during colony development. Degrades leupeptin into three components, acetyl-leucine, leucine and argininal. Has a strict preference for leucine at the P1 site.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MSLSVSRRLAAVTAFAVAGLFASAVPAALAAPSAVAAAPTPPDIPLANVKAHLSQLSTIAANNGGNRAHGRAGYKASIDYVKGKLDAAGFTTTLQTFTSSGATGYNLIADWPGGDPNSVLMAGSHLDSVTSGAGINDNGSGSAAVLETALAVSRAGLQPTKHLRFGWWGAEELGLIGSKYYVNNLPAAEKAKISGYLNFDMIGSPNPGYFVYDDDPTIEQTFKNYYAGLGVPTEIETEGDGRSDHAPFKNAGIPVGGLFSGADYTKTAAQAQKWGGTSGQAFDRCYHSSCDSLTNINDTALDRNSDAVAYAIWTLGAGTPVPPGQSFENTADVNVPDSPAAAVSSPITVSGVTGNAPATTKVDVNIVHTYRGDLVVDLVAPDGTVYNLHNRSGGSADNLVQTYTVNASSEVANGVWNLRVKDTAAQDVGYINSWKITF
Protein: Uncharacterized protein Rv0501 (P9WKT3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv0502
- UDP-galactopyranose mutase
- UDP-glucose 6-dehydrogenase
- UDP-glucose 4-epimerase
- Possible dTDP-glucose 4,6-dehydratase
- UTP--glucose-1-phosphate uridylyltransferase
- Galactose-1-phosphate uridylyltransferase
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS17
Sequence:
MSSSNGRGGAGGVGGSSEHPQYPKVVLVTGACRFLGGYLTARLAQNPLINRVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHAAAASYAPRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGSSPHDPVMFTEDSSSRRPFSQGFPKDSLDIEGYVRALGRRRPDIAVTILRLANMIGPAMDTTLSRYLAGPLVPTIFGRDARLQLLHEQDALGALERAAMAGKAGTFNIGADGILMLSQAIRRAGRIPVPVPGFGVWALDSLRRANHYTELNREQFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDDYFRGRGLTPIIDPHRVRSWEGRAVGLAQRWGSRNPIPWSGLR
Protein: Protein KIBRA (WW and C2 domain-containing 1) (E9QGC4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- APC regulator of WNT-signaling pathway 2.
- non-specific serine/threonine protein kinase
- Wilms tumor protein 1-interacting protein homolog
Sequence:
MPRKELPLPEGWEEARDFDGKVYYIDHINQTTSWIDPRDRQTKPLTFADCIGDELPVGWEEAYDPHVGAYYVDHNTKSTQLEDPRAQWQREQELMLHDYLNVVQEALSAQKEIYQVKEQRLRLAQQEYRQLNDAWRDKSSSQTSLNSRSSSSSKYDPEILKAEIVTAKSRVNKLKRDLAYMKQELHYKEQGFETLKEIDHKVSSASHGYKLHEAQAILKEVKSIKDAISSGEKEKQELMRKLAVLKDGFQLDYGSQSDLWASNPSLANSNLSLPRLYSDAESQTDIPAQFVSSSNKLAEKVRLSLKYEEAKRRIANIEVQIAKLDSEAWPGLLDPERDRLILINEKEELLKELQYVRPCKRAPNEAEKIESEKKRLEKDLQAARDNQSKALTERLRLHYRRNKLVKELEETVRVASSLHTQLKSLSASTLSCSSGSSRGSLTSSRGSLANSSLGSTSSLSFTDVYLEQPELGDPDFQNKLDSILQEGSTSGYRPSSSITTIHENEVSSSSVQIGGGPGVGQRTQVLRLSETPHSMNSLSPRSSLSSLSPPCSPLVTEASFLSGEVFSGPASQLDLDLQTRLMELRLEEDQQQGQLNYQDNKQESIMAVESSKDAVTQTRGSGPGSKKAGVTSAVSDESVAGDSGVYEPSEKRPGLPVEQLLAFDDGSSASSAQIKLGLKYEVKEKRFTVFVMQLSNYSALSLPANQNIYVRVVVLPCSETVRCLFRTHCALPQEPVELKEAFSLQVSSTALRQKTLRIDVCTTSKSGREHCLAGAQISLADEEYSEEWCTKWYNLLNCTYMPEMDGKQKETEMPALQELTPASSENAASCMENVPLEDWPAETLEGDVFVDEEGSDGEEGEEFYPDDCQWEQEEEPLKAGPTTVIAEKVNKETSMDGLPHSTSVVRPKERRHDVHQQNPFMRGNTIIRSKTFSPGPQSQYICRINRSDSDSSTLSKKSPFVRNASERRSVRMKKPPMQVKGLDGLLRTSLDLELDLQVTRTRHSRLTEELRVLRELKEQMEKARQQGQHVLPTWVQEDERFCLLLKHAERQTQEEQLQEKRVEKMMRAAAKDVHKIRGQSLKEVPGVQSFREKMAFFTRAKINVPDLPADDV
Protein: High mobility group B protein 9 (Nucleosome/chromatin assembly factor group D 09) (Nucleosome/chromatin assembly factor group D 9) (Protein NUCLEAR FUSION DEFECTIVE 9) (Q9SGS2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds preferentially DNA with A/T-rich content. Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:19053246}.
Interaction partners:
- Actin-related protein 4
- At3g01890
- SWI/SNF complex component SNF12 homolog
- Chromatin structure-remodeling complex protein BSH
- Histone deacetylase complex subunit SAP18
- Histone H4
- Actin-related protein 9
- Chromatin structure-remodeling complex protein SYD
- Actin-related protein 5
- SWI/SNF complex subunit SWI3D
Sequence:
MSSDNESTPSQATVEMMATSPAKIKEYPEPLALHEVVVKDSSVFWDTLRRFHSIMSTKFMIPVIGGKELDLHVLYVEVTRRGGYEKVVVEKKWREVGGVFRFSATTTSASFVLRKHYLNLLFHYEQVHLFTARGPLLHPIATFHANPSTSKEMALVEYTPPSIRYHNTHPPSQGSSSFTAIGTIEGKFDCGYLVKVKLGSEILNGVLYHSAQPGPSSSPTAVLNNAVVPYVETGRRRRRLGKRRRSRRREDPNYPKPNRSGYNFFFAEKHCKLKSLYPNKEREFTKLIGESWSNLSTEERMVYQDIGLKDKERYQRELNEYRETLRLRDGDMTNGKAF
Protein: G2/mitotic-specific cyclin-3 (P24870)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
Interaction partners:
- Cyclin-dependent kinase 1
- Cyclin-dependent kinases regulatory subunit
- Protein SIC1
- G1/S-specific cyclin CLN1
- G1/S-specific cyclin CLN3
- APC/C activator protein CDH1
- G2/mitotic-specific cyclin-4
- G1/S-specific cyclin CLN2
- G2/mitotic-specific cyclin-2
- Tyrosine-protein phosphatase CDC14
Sequence:
MHHNSQSLSSGHIRSPEDENVAPIGNLKHRTGSLSHISSAHPRVALSDVTNIVATNSSNNSISKPKVAPIKERLDSAAIIEEERLDANSVAQRKEADHNDLLTDREQEEPVEDDGESEEDEEEDQEPLLLQHYASDTLVWEHAFRTYYRTTLDPNDDDVYDVVMVAELSNEIFEYMRKLEDLYKPNPYYMDKQPELRWSFRSTLIDWIVQVHEKFQLLPETLYLCINIIDRYLCKEVVPVNKFQLVGAASLFIAAKYEEINCPTIKDFVYMSENCYSRNDLLDAERTILNGLEFELGWPGPMSFLRRISKADDYEHDTRTLAKYLLESTIMDHRLVSAQPSWLAAGAYFLSKIILGQNQWSLAHVYYSNYTQEQILPLATIILENCRYASKRHNAIWRKYSSRRYLHSSQIVAKWIALAEHRVERSN
Protein: Terpenoid synthase 26 (AtTPS26) (EC 4.2.3.-) (Q9C8E3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in terpene biosynthesis in roots. Possesses sesquiterpene (C15) synthase activity and diterpene (C20) synthase activity in vitro.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Probable alpha,alpha-trehalose-phosphate synthase 7
- Putative inactive
- Geranylgeranyl pyrophosphate synthase 3, chloroplastic
- Probable alpha,alpha-trehalose-phosphate synthase 8
- Probable alpha,alpha-trehalose-phosphate synthase 11
Sequence:
MEAKFGSQISLHFRTNSFPLRKLYGFPLTTFSGTSLNHLRLKATNTLKGDDQESIRKFKKLPTSEWTHYFHSFVVDVSEMDALRNEIDALKPKVKNTIMSSQGIDSTKKRILMIYMLVSLGLAHHFEEEIYETLRDGFGKIEEMMEDEDDLCTVSIIFWAFRRYGHYISSDVFRRFKGSNGNFKESLTGYAKGMLSLYEAAHLGTTKDYILQEALSFTSSHLESLAACGTCPPHLSVHIQNVLSVPQHWNMEILVPVEYIPFYEQEKDHDEILLKFAKLSFKLLQLQYIQDLKIVTKWYKELEFASKLPPYFRDNIVVNYFYVLAVIYTPQHSYERIMLTQYFTCLAILDDTFDRYASLPEAISLANSLERWAPNDAMDKQPDYLKIVLNFILKTFEVFQKELEPEGRSYTVKATIEEFKTVTKGNFDLAKWAHAVHVPSFEEYMEVGEEEISVCSTLAGIFMCMEQKATKEDYEWLKSRPKFIQTLCARCRLKNDITGFEDDMSRGYVTNAVNCYMKQYGVTKQEAFGELNKIIVEADKILNEEFLTTVGVRHCVLKATFDLARMIFITYNGYEGFTYPQGKIKEYMTSLFVDRIGL
Protein: Protein PBP4 (PBP1-binding protein 4) (Q07362)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- PAB1-binding protein 1
- Protein LSM12
- Polyadenylate-binding protein, cytoplasmic and nuclear
- mRNA-binding protein PUF3
- Small nuclear ribonucleoprotein-associated protein B
Sequence:
MTTTSTTSVDGRTSSTLKATLSASGPNSNGPTPAVLPQKPKLTGWAQAAAKALPRQQQQQQQARKDDSVAVQPANTKTKTIASTAPPANIKGSSTANGSSTNKKFKRANKQPYNREEVRSYMHKLFQSYTAGEKSHSMKTYKQVLSETASGRVSTATDWGTVSSSKNKNKKYGCLSDIAKVLRNQ
Protein: Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (EC 1.3.1.124) (2,4-dienoyl-CoA reductase 2) (A0A8I6GLQ6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTVFLNTTTSSARTFSRCVPHTFLLRPAFSVCRHGCHTVIVSRSLPRVSEAAKKLVAATGKRCLPLSMDVRVPPAVMAAVDQALKEFGKIDILINCAAGNFLCPASALSFNAFKTVVDIDTLGTFNVSRVLYEKFFRDHGGVIVNITATLSMRGQVLQLHAGAAKAAVDAMTRHLAVEWGPQNIRVNSLAPGAISGTEGLRRLGGPKASSKFKYLSSPIPRLGTKTEIAHSVLYLASPLASYVSGIVLVVDGGSWMTLPNDIGRLLEFESSSAKL
Protein: Zfp111 protein (Zinc finger protein 111) (Q99K53)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MTKLQEAVTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQSPNKMEIVDATGLRCLSLGQLLCWGETSHNINKLARALEAVINTQGKCSHSLEQCHSSCHRVSEEPPRDSEDSSSPDLTNDHSSITENQEFLSGRAQGSWGKRRLRKRQNHQKNCLQTLMKNKPQLLAQHSPVHSTQEDTRHSFSVPVQESIYPGRKRYRCQECGKAFRQSSALQTHQRVHTGEKPYRGNSRGKNFSRSSDLNIHRQVHTREKPYTCKVCKKRFMQCSLLQAHKRIHTGEKPYKCGDCGKRFSCISNFHIHQRVHTKSKPSKCDYGKPFNLRCNFHSHQRVHTGEKPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKGFSRTSYLQTHQRVHSGDKPYQCDSCGKGFTQLSHLQAHERIHTDQKPYKCGDCGKRFSCSSNLHTHQRVHTGEKPYKCEECGKGFSLVSGLQAHQRVETGKKPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSLNSGLIAHRRVHTGEKPYECKDCGKGFSLASSLRTHQRVHTGEKPFQCNECQKRFSQVSHLQSHQRVHTGEKPYKCDRCGKAFSQKSGLQVHKRIHTGEKPFKCEECGKEFIWSSGLSAHRKVHTGEKPYRRRQYGKGLIRPHTSD