wanglab/gogpt-training-data huggingface dataset:
Protein: Formin homology 2 domain containing, isoform E (M9MRS9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIVKMEPDELITFRVQYLVDSDPLSACTAFPIPVRAPTYAFATTMPLANQLGTILRLLNAPQSIDDAAIQVYKDGDYGAYLDLESSLAEQAEEIEGVNVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQVFQEDKDLVHAFVALGGLNCLVRVGNCADQNYQNYILRALGQVMLYVDGMNGVMKHEPTMQWLYSLIASNYRSVVKTALKLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELVIYATSLINKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDGESDGQRLPQNSMRKTQRYRPGANTTERRKSRRHSTDNSPASLTKVLPTTVLRMTPTQATVDEDSSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSFLKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGDSPPQSLQHEVPPCNNISGITNISNNNVSNLSCNDTPNNSLLVMSPSKQLLTGSHSISIINNSFDKASNNNQSEFLTKKNLFRERNSTVINGIMKNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQPTPEVLLSPKKTLNASGFDFTPAPLSSTPVKCDVPPEPEPLSPVKKPAAAPPPPPPPPPPPPPPPGWWHAPIYNSPQARTLTSTNPELLPHPVDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLPMSPTQDSANRALVGDMSGLISKAKEGLAKSKSKGEISRSSSVDQDVKKSEPKKSENELHWEELVRNMTRPLNLCDLDFTDLRDDDEKDVLAPRSLGAGIPPPPPPLGGAIAPPPMMPPSLAPPPMYGYGGSLTNSVNSLNGSINGELVNGNNTIKKNKKTVKLFWKEVREDMIPQVVGKTIWDELPDANVDTQKLEHLFESRAKDLMTKKQQELNKSKEIIVLDHKRSNAINIAITKLPPPRAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKIQEAQLSNPELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILSTLLSVGIFLNGAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPITRASKADFTDLAHNLNQLEAECKACWDRLKLIAKHDCPPPLKQKLVDFLADCAERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTTRERVQQQLEKKANHRERNKTRGKLIIDMAKFKTKDDVADDELKKLLDTSSADQADGTLTWRRRRAEQLRSPITRQSEEQFTDGDDEILESLVKTATKAPGTRTTPRERKRTRHADRKSLKRSRTREGFTVERAPSP
Protein: Falcipain-3 (EC 3.4.22.-) (Cysteine proteinase falcipain-3) (Q8IIL0)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000269|PubMed:11716777, ECO:0000269|PubMed:17565983}; Single-pass type II membrane protein {ECO:0000305}. Vacuole {ECO:0000269|PubMed:11716777, ECO:0000269|PubMed:15664655, ECO:0000269|PubMed:17565983}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17565983, ECO:0000305|PubMed:15664655}. Note=In mature trophozoites, localization is diffused throughout the cytoplasm (PubMed:15664655). In late trophozoites, the mature form localizes to the digestive (or food) vacuole, an acidic vacuole where host hemoglobin is digested (PubMed:11716777, PubMed:15664655, PubMed:17565983). The proenzyme localizes to the membrane (PubMed:11716777). {ECO:0000269|PubMed:11716777, ECO:0000269|PubMed:15664655, ECO:0000269|PubMed:17565983}.
Interaction partners:
- ADP/ATP translocase
- Uncharacterized protein
- non-specific serine/threonine protein kinase
- Uncharacterized protein
- DNA polymerase II subunit 2
- Ribosome-interacting GTPase 1, putative
- Raf kinase inhibitor
- Citrate synthase-like protein, putative
- Citrate synthase
- Syntaxin, Qa-SNARE family
Sequence:
MEYHMEYSPNEVIKQEREVFVGKEKSGSKFKRKRSIFIVLTVSICFMFALMLFYFTRNENNKTLFTNSLSNNINDDYIINSLLKSESGKKFIVSKLEELISSYDKEKKMRTTGAEENNMNMNGIDDKDNKSVSFVNKKNGNLKVNNNNQVSYSNLFDTKFLMDNLETVNLFYIFLKENNKKYETSEEMQKRFIIFSENYRKIELHNKKTNSLYKRGMNKFGDLSPEEFRSKYLNLKTHGPFKTLSPPVSYEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLLE
Protein: Kinetochore protein Spc24 (hSpc24) (Q8NBT2)
Organism: Homo sapiens (Human)
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Subcellular location: Nucleus {ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:15561729, ECO:0000269|PubMed:15961401, ECO:0000269|PubMed:15964272}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:15561729, ECO:0000269|PubMed:15961401, ECO:0000269|PubMed:15964272}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. {ECO:0000269|PubMed:14738735}.
Interaction partners:
- Kinetochore protein Spc25
- Kinetochore protein NDC80 homolog
- Kinetochore protein Nuf2
- Kinetochore-associated protein DSN1 homolog
- Protein MIS12 homolog
- Outer kinetochore KNL1 complex subunit KNL1
- Centromere protein T
- Outer kinetochore KNL1 complex subunit ZWINT
- Kinetochore-associated protein NSL1 homolog
- Polyamine-modulated factor 1
Sequence:
MAAFRDIEEVSQGLLSLLGANRAEAQQRRLLGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVELQQLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDEDTTVTIPSAVYVAQLYHQVSKIEWDYECEPGMVKGIHHGPSVAQPIHLDSTQLSRKFISDYLWSLVDTEW
Protein: WD repeat-containing protein RUP2 (Protein EARLY FLOWERING BY OVEREXPRESSION 2) (Protein REPRESSOR OF UV-B PHOTOMORPHOGENESIS 2) (Q9FFA7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions in association with RUP1 as repressor of UV-B-induced photomorphogenesis mediated by UVR8 and HY5. Plays a crucial negative feedback regulatory role downstream of UVR8-COP1 to inhibit UVR8 function, balance UV-B-specific responses and ensure normal plant growth. Is involved in the regulation of photoperiodic flowering and vegetative development. May act as negative regulator of photoperiodic flowering by suppressing flowering through the action of CONSTANS (CO) and FLOWERING LOCUS T (FT).
Subcellular location: Nucleus {ECO:0000269|PubMed:21041653}. Cytoplasm, cytosol {ECO:0000269|PubMed:21041653}.
Interaction partners:
- Ultraviolet-B receptor UVR8
- Transcription factor HY5
- Transcription factor HY5-like
- Transducin/WD40 repeat-like superfamily protein
- WD repeat-containing protein ATCSA-1
- Cryptochrome-2
- Cryptochrome-1
- Cullin-4
- E3 ubiquitin-protein ligase COP1
- Protein DWD HYPERSENSITIVE TO UV-B 1
Sequence:
MNTLHPHKQQQEQAQQQEEARYEWDLSLSTVVSSSSSSASDVIGAIEFDPTDNIVATAGISRKIRFYGLPSLLRNNAVSGTGVSFVDQATACEYYICTPAKLSSLRWRPGSGGRVIGSGDYDGVVMEYDLEKRTPVFERDEHGGRRVWSVDYTRHGGASTVGASGSDDGTMQVWDPRCPPEESVGVVRPAGICRSAVCCVEFDPSGGPAVAVGCADRKGYVYDIRKLVDPALTLQGHTKTVSYVRFLDGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHVNNRNFVGLSVWRNGALFGCGSENNRVFVYDRRWGKPVWVDGFEPVGMNSGSDKRFVSSVCWRQSGVDQCTLVAGGSDGVLQVYVGKRKP
Protein: GRAM domain-containing protein 2A (Q8IUY3)
Organism: Homo sapiens (Human)
Function: Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29469807}; Single-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:29469807}; Peripheral membrane protein {ECO:0000269|PubMed:29469807}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Anchored at the ER, PM binding is mediated via GRAM domain and phosphatidylinositol lipid interaction. Localizes to distinct EPCS than GRAMD1A. {ECO:0000269|PubMed:29469807}.
Interaction partners:
Sequence:
MTALSRSEATEEGGNQQMHRKTASLNSPVSCKEKPDRVEEPPDYSLHWPEGLKGEEIKKCGREGITLNKYNQQYHKLFKDVPLEEVVLKVCSCALQRDFLLQGRLYISPNWLCFHASLFGKDIKVVIPVVSVQMIKKHKMARLLPNGLAITTNTSQKYIFVSLLSRDSVYDLLRRVCTHLQPSSKKSLSVREFSGEPESLEVLIPEMKWRKVCPSSRSLSLPDNIPCIPPSSVDSTDSFFPSRKPPMSEKSRAQVASENGGRWAWPMPGWGPACPKKMPNCSPTAKNAVYEEDELEEEPRSTGELRLWDYRLLKVFFVLICFLVMSSSYLAFRISRLEQQLCSLSWDDPVPGHR
Protein: 5'-deoxynucleotidase (EC 3.1.3.89) (Q93ZV1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAVISPATRFAPPLNRPFHRRSILASFHSSSRNFLFLGKPTPSSTIVSVRCQKPVSDGVSSMESMNHVASSVSSSIDFLTLCHRLKTTKRKGWINQGINGPESIADHMYRMALMALIAGDLTGVDRERCIKMAIVHDIAEAIVGDITPSDGVPKEEKSRRETAALKEMCEVLGGGLRAEEITELWLEYENNASLEANIVKDFDKVEMILQALEYEAEHGKVLDEFFISTAGKFQTEIGKSWAAEINARRKSQLTNRQR
Protein: Protein Wnt (Q9YGX6)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
- Frizzled-1
- Frizzled-3
- Frizzled-2
- Frizzled-4
- Frizzled-6
- Frizzled-7
- Wnt inhibitory factor 1
- Low-density lipoprotein receptor-related protein
- Receptor like tyrosine kinase.
- Frizzled-10
Sequence:
MEKSTAVLIQGGALGTLGSTMASQYLVVALAIFSSCTQVVIEASSWWSLGMNPMNPMNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCQLYQDHMQFIGEGAKTGIKECQYQFRHRRWNCSTVDNNSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSSCGCSRAARPKDLPRDWLWGGCGDNIEYGYRFAKEFVDARERERVYQRGSYESARIMMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGKLVQMNSRFNAPTIHDLIYIDPSPDYCMRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQRERCHCKFHWCCYVKCKLCTEIVDQFVCK
Protein: Probable serine/threonine-protein kinase ndrC (EC 2.7.11.1) (Nuclear DBF2-related kinase C) (Q54P47)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Centrosomal protein 224
Sequence:
MSRKENLNRSSSSNSIEFNRDRDRDSSNISNSSNINCNNSSQTPPIPQHNSLSGRSKHSSPIHSLKKKGSLVRQGIEDLFSSLSVDTHSSSNSNNNSSSNNNNNNNNHNINSSSESSTPTTPRSSFTPQVTMNSNQSSGNNSPQLSSRSSSQSTLIPSNEPTKSLAKFFLLAQQVDYVGDSSSTLLPVENLGLLSIQWKTYFTIGLNSTTTGYDVLKYISIKTNRDLKSLTLADSDGKIIDNDYILTQQRCKKFVVVEDLNIDDLKMKQLNHLQQLPPPSQQQLPPPQSHQQQLLQQQLQQRLQNQNQNQNNNSNSNSNSSSSSSCSTPQSIVSQQQKLHQMLLNQQQIQSSQSTTPTNSSQKSSPNKVTDHQHVENCNFTSPSPSSPSSPSSPSSGMILDGFNLDGNGGRPTPLIITPSSPSSMRKNPPAIPPRSPSSFSGGSPLNNILLNNTELISEPVTTTTTTTTTTSSSSSLSVTTTISNPNYTQNLPTTPLSNSSSNNNNNGSFITLQDTTNNKSIINNNRESPPESPMGSRKSSGSSNTTSSTTNTTTPSSSSLTTSSGKESRDRDSKDKEKDLIGSGNNNNNNNNNNNNNNNNNKVEKEKENYCKFLDAVNSFNMVGNNGVLFNGEANRNMKLTNAQEEKCKILDNYFNHYYQELFKYLHQRHRRIKTIEDFTVESRMDRQGAEQWMKKQFEKETNFLRNKRAGMKLKEFKILTQIGKGGFGQVFLAQKKDTGDIVTLKRLKKQTVEWANQRNQVSQEKSVMLVDNKWITKLLYSFQDANYLYLAMEYHCGGDFRALLNNLGTLSEDEARFYMIEMIEAISSLHEMGIVHRDCKPSNFVLDKLGHIKLIDFGLSKEGIEKRNGWNKATMNELRKSCLSASFTSNTMKAASAYLSGGTNVMAYRRPIAHSAVGSPEYMSPEIVNDQGYDMTCDYWSLGCVFVEMLCGFNPFCADTPNDVFINILRWKETLDWPLFTQELSVEAADLLKNMLMEQPHRLGGKGKQDFKNHPFFKNHNWDEIVNGQVKPPFVPKVESDIDTSYFEDAVNNDSSTWDIDDNDCGGYGSGGYGGGGPQARDPFNNLKIPFFTYRKSSALSLSMSSEIAQSLNYNNGNTYSNYTSNNNNNNLHNNQIHEKNGNSGYNHFHFDSIEQQNQYQLSLLSPNSSDKSIGMIQYIKKFRYQQLQQQLQQHFQQQNHLQQLKSNHRKSPTRQLISSLLYKGDDKTSILQNYSSQSQPSLANQLQSSSSSPSPSLQSQSQSPSLQSSSKSTPNLSSSLLENPVKEELEYKNQTENEVEIKKENESEEIQSLRDQLKEIIIYEDYDQEYSI
Protein: Apoptosis-inducing factor 3 (Apoptosis-inducing factor mitochondria-associated 3) (F2Z4R3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Synaptosome-associated protein 29.
- Si:ch211-282e16.1
- Cationic amino acid transporter 4
- Sulfite oxidase, mitochondrial
- Phosphatidylinositol 4-kinase, catalytic, alpha a
- Kelch-like protein 22
- Leucine-zipper-like transcription regulator 1.
- Crk-like protein-like)
- Transport and Golgi organization protein 2 homolog)
- Large ribosomal subunit protein mL40
Sequence:
MGGCLSKPKPVEVKVELTLLDKEKEVDLMSPNGKASPFSECRPNGSLGHCSDEDSMTLRPQRKNRDYIEASVCHIKDLENGQMREVDLGAGRALLIKEHGEFFAMGHKCPHYGAPLVKGVLSKGHVRCPWHGACFNIATGDIEDFPGLDSLPTFQVRVEKEKVIIRANKQALQTQRRSKVMSKCSAVINSSTGFSHVLIIGSGPAGLVCAETLRQEGFTDRIVICTTDKHLPYDRPKLSKSLESTAEQLQLRSSDFFQMHDIEVLLEKEVVSVDVKTHTVTFRDGFKMEYRKLFIATGSRPKPLSYKGKDVGNVFHLRTPEDANSIVTLASSKNAVIIGTSFIGMEVAAALTDKAHSVSVIGIEAVPFRKALGEKVGKALMKLFESNRVKFYMLNEVWEMRGHNGQLKEVVLKSGKVLRADVCVIGIGSSPATAFLKQSGVHIDSKGFIPVNKTMQTNIDGVFAGGDVVTFPLGLRSNKKVNIPHWQMAHVHGRLAALGIMGKASDIKTVPYFWTAMFGKSIRYAGYGDGFDDVVIQGDLDELKFVAFYTKSEEVVAVASMNYDPIVSRVAEVFGSGKTIRKRDVETGDMSWLIVKGSQ
Protein: Pigment dispersing factor homolog pdf-1 (G8JYC6)
Organism: Caenorhabditis elegans
Function: Probable ligand of isoforms a and b of the calcitonin receptor-like protein, pdfr-1, a G-protein coupled receptor. May not signal through isoform c of pdfr-1. Involved in locomotion; more specifically mate searching behavior of males, independent of nutritional status. Involved in regulating the male-specific expression of TGFbeta-like daf-7 in the ASJ chemosensory neurons. Plays a role in circadian rhythms of locomotor activity. Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide flp-2. In the presence of food, plays a role in initiating and extending exploratory roaming behavior, in opposition to 5-hydroxytryptamine (serotonin) signaling.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Pigment dispersing factor homolog pdf-2
- Calcitonin receptor-like protein 1
- Protein flightless-1 homolog
- FMRFamide-like neuropeptides 2
- FMRFamide-like neuropeptide 18
- Neuropeptide-Like Protein
- FMRFamide-like neuropeptide 21
- FMRFamide peptide receptor frpr-18
- FMRFamide-like neuropeptides 11
Sequence:
MNRFIISMIALLAVFCAVSTASPLLYRAPQYQMYDDVQFVKRSNAELINGLIGMDLGKLSAVGKRSNAELINGLLSMNLNKLSGAGRR
Protein: Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase) (Q9WTS2)
Organism: Mus musculus (Mouse)
Function: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.
Interaction partners:
- Beta-1,4-galactosyltransferase 1
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Alpha-mannosidase 2
- Alpha-mannosidase 2x
- Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
- Beta-1,4-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 3
- Beta-1,4-N-acetylgalactosaminyltransferase 3
Sequence:
MRAWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHPDHSSRELSKILAKLERLKQQNEDLRRMAESLRIPEGPIDQGTATGRVRVLEEQLVKAKEQIENYKKQARNGLGKDHEILRRRIENGAKELWFFLQSELKKLKHLEGNELQRHADEILLDLGHHERSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKARKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESQNWRYATGGWETVFRPVSETCTDRSGLSTGHWSGEVNDKNIQVVELPIVDSLHPRPPYLPLAVPEDLADRLLRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKHPVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLATDDPTLLKEAKTKYSNYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQTLHPDASANFHSLDDIYYFGGQNAHNQIAVYPHKPRTEEEIPMEPGDIIGVAGNHWDGYSKGINRKLGKTGLYPSYKVREKIETVKYPTYPEAEK
Protein: Putative RING zinc finger protein (RING/U-box superfamily protein) (Q9SFV0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ubiquitin-related modifier 1
- Uncharacterized protein At5g02240
- Ubiquitin-like superfamily protein
- Zinc ion binding protein
- Cysteine proteinases superfamily protein
- Probable ubiquitin-like-specific protease 2B
- Ubiquitin-ribosomal protein eL40y fusion protein
- Ubiquitin-ribosomal protein eL40z fusion protein
- Probable ubiquitin-like-specific protease 2A
- Ubiquitin-ribosomal protein eS31x fusion protein
Sequence:
MASRVVRTSMRLRRRDGVTQNEHQGDQQVADQAPTVPQIVATPPRINVVAIEDDDDVVESTASAFAQAKNKSRSARRGSQVVDVESAGANRSTRRRSDQTSVDSVELNKPRKSKAVAPPVEEPKFSCPICLCPFTQEVSTKCGHIFCKKCIKNALSLQAKCPTCRKKITVKDLIRVFLPTTR
Protein: CCR4-NOT transcription complex subunit 11 (Q9UKZ1)
Organism: Homo sapiens (Human)
Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 2
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex subunit 6
- CCR4-NOT transcription complex subunit 6-like
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 8
- 182 kDa tankyrase-1-binding protein
Sequence:
MPGGGASAASGRLLTAAEQRGSREAAGSASRSGFGGSGGGRGGASGPGSGSGGPGGPAGRMSLTPKELSSLLSIISEEAGGGSTFEGLSTAFHHYFSKADHFRLGSVLVMLLQQPDLLPSAAQRLTALYLLWEMYRTEPLAANPFAASFAHLLNPAPPARGGQEPDRPPLSGFLPPITPPEKFFLSQLMLAPPRELFKKTPRQIALMDVGNMGQSVDISGLQLALAERQSELPTQSKASFPSILSDPDPDSSNSGFDSSVASQITEALVSGPKPPIESHFRPEFIRPPPPLHICEDELAWLNPTEPDHAIQWDKSMCVKNSTGVEIKRIMAKAFKSPLSSPQQTQLLGELEKDPKLVYHIGLTPAKLPDLVENNPLVAIEMLLKLMQSSQITEYFSVLVNMDMSLHSMEVVNRLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVRLVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRIREAAGLFRLLKTLDTGETPSETKMSK
Protein: Thiamine pyrophosphokinase (TPK) (Thiamine kinase) (EC 2.7.6.2) (P41888)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the regulation of thiamine metabolism, phosphate metabolism, mating and cell growth.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Thiamine thiazole synthase
- Thiamine repressible genes regulatory protein thi1
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1
- Thiamine-repressible acid phosphatase pho4
- Probable transketolase
- Eukaryotic translation initiation factor 4E-2
- Thiamine transporter thi9
Sequence:
MAMSSITSAKQLNAEELLDECDSFNGEFVPGTIPFRANGAAIGYVTPLVLEILIKADNFKFNWVYVPGEYIEINASTFEKRTDILAKVLEHWRHNNTFGIADQWRNELYTVYGKSKKPVLAVERGGFWLFGFLSTGVHCTMYIPATKEHPLRIWVPRRSPTKQTWPNYLDNSVAGGIAHGDSVIGTMIKEFSEEANLDVSSMNLIPCGTVSYIKMEKRHWIQPELQYVFDLPVDDLVIPRINDGEVAGFSLLPLNQVLHELELKSFKPNCALVLLDFLIRHGIITPQHPQYLQTLERIHRPLPVPVGKYERGDSFEDTSKKAETCVPAKPQKATHQLAPCKAWLRDYDTDQKFAVLLLNQPIDIPDDRFRTLWKRASIRVCADGGANQLRNYDSSLKPDYVVGDFDSLTDETKAYYKEMGVNIVFDPCQNTTDFMKCHKIIKEHGIDTIFVLCGMGGRVDHAIGNLNHLFWAASISEKNEVFLLTELNVSTLLQPGINHVDCHDNIGLHCGLLPVGQSVYVKKTSGLEWNIEDRICQFGGLVSSCNVVTKATVTIEVNNFIVWTMETRL
Protein: 3-hydroxyacyl-thioester dehydratase Z (EC 4.2.1.-) (3-hydroxybutyryl-CoA dehydratase) (EC 4.2.1.55) (Enoyl-CoA hydratase 2) (EC 4.2.1.119) (N-related protein) (Nodulation protein) (P9WNP3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Shows trans-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase activity. In vitro, can hydrate (2E)-butenoyl-CoA, (2E)-hexenoyl-CoA and (2E)-decenoyl-CoA.
Interaction partners:
- Probable NADPH quinone oxidoreductase FadB4
- Possible quinone oxidoreductase
Sequence:
MRTFESVADLAAAAGEKVGQSDWVTITQEEVNLFADATGDHQWIHVDPERAAAGPFGTTIAHGFMTLALLPRLQHQMYTVKGVKLAINYGLNKVRFPAPVPVGSRVRATSSLVGVEDLGNGTVQATVSTTVEVEGSAKPACVAESIVRYVA
Protein: Protein phosphatase 1 regulatory subunit 8 (A0A0A0MT09)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVEGPGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIHGTALIGGLPMPYPNLAPDVDLTPVVPSAVNMNPAPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTP
Protein: Uncharacterized protein Rv1591 (P9WLT5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Biotin synthase
- Biotin synthase auxiliary protein
Sequence:
MLGLSATGVLVGGLWAWIAPPIHAVVAITRAGERVHEYLGSESQNFFIAPFMLLGLLSVLAVVASALMWQWREHRGPQMVAGLSIGLTTAAAIAAGVGALVVRLRYGALDFDTVPLSRGDHALTYVTQAPPVFFARRPLQIALTLMWPAGIASLVYALLAAGTARDDLGGYPAVDPSSNARTEALETPQAPVS
Protein: tRNA-dihydrouridine synthase (EC 1.3.1.-) (Q9FI41)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- tRNA-uridine aminocarboxypropyltransferase
- tRNA-uridine aminocarboxypropyltransferase A
- Monothiol glutaredoxin-S11
- Phosphatidylinositol N-acetyglucosaminlytransferase subunit P-like protein
- tRNA
- tRNA
- tRNA
- At2g39210/T16B24.15
Sequence:
MTVSEAYSPPLFSIAPMMGWTDNHYRTLARLITKHAWLYTEMLAAETIVYQEDNLDSFLAFSPDQHPIVLQIGGRNLENLAKATRLANAYAYDEINFNCGCPSPKVSGRGCFGALLMLDPKFVGEAMSVIAANTNAAVTVKCRIGVDDHDSYNELCDFIHIVSSLSPTKHFIIHSRKALLSGLSPSDNRRIPPLKYEFFFALLRDFPDLKFTINGGINSVVEADAALRSGAHGVMLGRAVYYNPWHILGHVDTVVYGSPSSGITRRQVLEKYKLYGESVLGKYGKGRPNLRDIVRPLINLFHSESGNGQWKRRTDAALLHCTTLQSFLDEVLPAIPDYVLDSSAVKEATGREDLFADVQRLLPPPYEKESFKALERIPTRPVILDEE
Protein: Type II iodothyronine deiodinase (EC 1.21.99.4) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase) (Q92813)
Organism: Homo sapiens (Human)
Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11089566}; Single-pass type III membrane protein {ECO:0000305|PubMed:11089566}.
Interaction partners:
- Type I iodothyronine deiodinase
- Selenocysteine insertion sequence-binding protein 2
- Monocarboxylate transporter 8
- WD repeat and SOCS box-containing protein 1
- Mitochondrial brown fat uncoupling protein 1
- Pro-thyrotropin-releasing hormone
- G-protein coupled bile acid receptor 1
- Lipid transferase CIDEA
- Solute carrier organic anion transporter family member 1C1
- Thyrotropin subunit beta
Sequence:
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG
Protein: Small integral membrane protein 34 (A8MWV9)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial
Sequence:
MEWAKWTPHEASNQTQASTLLGLLLGDHTEGRNDTNSTRALKVPDGTSAAWYILTIIGIYAVIFVFRLASNILRKNDKSLEDVYYSNLTSELKMTGLQGKVAKCSTLSISNRAVLQPCQAHLGAKGGSSGPQTATPETP
Protein: Lysine-sensitive aspartokinase 3 (EC 2.7.2.4) (Aspartate kinase III) (AKIII) (Lysine-sensitive aspartokinase III) (P08660)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Aspartate-semialdehyde dehydrogenase
- Diaminopimelate decarboxylase
- Bifunctional aspartokinase/homoserine dehydrogenase 2
- Bifunctional aspartokinase/homoserine dehydrogenase 1
- Homoserine kinase
- Argininosuccinate synthase
- 4-hydroxy-tetrahydrodipicolinate synthase
- 4-hydroxy-tetrahydrodipicolinate reductase
- Asparagine synthetase B
- Aspartate aminotransferase
Sequence:
MSEIVVSKFGGTSVADFDAMNRSADIVLSDANVRLVVLSASAGITNLLVALAEGLEPGERFEKLDAIRNIQFAILERLRYPNVIREEIERLLENITVLAEAAALATSPALTDELVSHGELMSTLLFVEILRERDVQAQWFDVRKVMRTNDRFGRAEPDIAALAELAALQLLPRLNEGLVITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGIYTTDPRVVSAAKRIDEIAFAEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPRAGGTLVCNKTENPPLFRALALRRNQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTLDTTGSTSTGDTLLTQSLLMELSALCRVEVEEGLALVALIGNDLSKACGVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGEDAEQVVQKLHSNLFE