wanglab/gogpt-training-data huggingface dataset:
Protein: Thymidine kinase (EC 2.7.1.21) (Q3KSQ2)
Organism: Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)
Function: Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
Subcellular location: Virion tegument. Host nucleus {ECO:0000250}. Note=Localizes to the centrosome and more precisely to the periphery of the centriole, tightly encircling the tubulin-rich centrioles. {ECO:0000250}.
Interaction partners:
Sequence:
MAGFPGKEAGPPGGWRKCQEDESPENERHENFYAEIDDFAPSVLTPTGSDSGAGEEDDDGLYQVPTHWPPLMAPTGLSGERVPCRTQAAVTSNTGNSPGSRHTSCPFTLPRGAQPPAPAHQKPTAPTPKPRSRECGPSKTPDPFSWFRKTSCTEGGADSTSRSFMYQKGFEEGLAGLGLDDKSDCESEDESNFRRPSSHSALKQKNGGKGKPSGLFEHLAAHGREFSKLSKHAAQLKRLSGSVMNVLNLDDAQDTRQAKAQRKESTRVPIVIHLTNHVPVIKPACSLFLEGAPGVGKTTMLNHLKAVFGDLTIVVPEPMRYWTHVYENAIKAMHKNVTRARHGREDTSAEVLACQMKFTTPFRVLASRKRSLLVTESGARSVAPLDCWILHDRHLLSASVVFPLMLLRSQLLSYSDFIQVLATFTADPGDTIVWMKLNVEENMRRLKKRGRKHESGLDAGYLKSVNDAYHAVYCAWLLTQYFAPEDIVKVCAGLTTITTVCHQSHTPIIRSGVAEKLYKNSIYSVLKEVIQPYRADAVLLEVCLAFTRTLAYLQFVLVDLSEFQDDLPGCWTEIYMQALKNPAIRSQFFDWAGLSKVISDFERGNRD
Protein: Periostin, osteoblast specific factor b isoform X1 (Periostin, osteoblast-specific factor b) (A0A0R4IS83)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MKLLFAATFALFVLSAFDQADSSAYDKIVAHSRIRAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKTATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFFAPSNDAWDLLEAEVRNALVSNVNIELYNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLSTLSTVATDSGLIDKLGEPGHFTLFAPTNAAFDKLGREVLDRLMKDKKSLQALLNYHLLNSVQCSEAIMAGTSHETLEGSNIEIGCDGDSLTVNGIKMVLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTELGLSAAMRPQAEYTLLAPVNAAFNDEVMSMDQSFLKIILENHILKNKIVLSQLYNGQRLETLSGKFLRVFVYRTALCIENACLIRGSKEGSNGALHLMKTLISPAESSMFQILVKNGAFKIFLSLMEAAGLTDLLKQEGDFTLFAPTDEAFAGLSERDLTLLKSNGNALKAILLYHFSNGVFIGGGLETGVTNLLKTLQGSNLRVLYANASMLVNTVKVPEPDIMATNGVVHFVRTLLYPEDIPVGSQDLLSLLRRIIRYIQFKFVPGYRYQEIPLTFMRRVITVPGDVTKVTRVIQGEPTITKVTRVIEGAPSVTKVTRVIEGQPSITKVTRVIEGQPSLTKVTRVIEGDPSMTRVIEGPEYSVTSSTDTELYDFGEDSEGITTFIQEGTRRVPPRRVQGGVRRRT
Protein: O-acyltransferase WSD1 C-terminal domain-containing protein (O06577)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable epoxide hydrolase EphC
- Polyketide synthase Pks13
- Mycoketide-CoA synthase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Mycocerosic acid synthase-like polyketide synthase
- Phthioceranic/hydroxyphthioceranic acid synthase
- Probable multifunctional mycocerosic acid synthase membrane-associated Mas
- Possible conserved secreted protein
- Uncharacterized protein Rv2876
- Protein Rv3035
Sequence:
MAGHRMAAVDAQFYWMSAKVPNDQFLLYAFDGEPTDLERAVAQVYRRARGCPGLGMRVQDRGALAYPQWVPTPVQRDQLVCHDLADRSWQGCLAAVVGLASKQLDMRRMPWRLHVFTPVHDVPGVSGLGTVAVMQFAHALGDGARASAMAAWLFGRPAAVPEIARSRAGFLPWRAAHAARAHLRLVRDTNAGLVAPGVGSRPPLSTNARPEGVRAVRTLLRRRSQLAGPTVTVTVLAAVSTGLLGLLGGDVDTLGAEVPMAKPGVPRSYNHFGNVVVGLYPRLEPDERVRRIATDLANARRRFEHPAMLSADRAFAAVPAALLRWGVSQFDAEVRPVRVAGNTVVSSVYRGAADLSFGDAPVVLTAGYPALSPAMGLTHGVHGIGDTVAISVHAAESAVSDIDAYMRLLDAALQ
Protein: Mucin-15 (MUC-15) (Q8N387)
Organism: Homo sapiens (Human)
Function: May play a role in the cell adhesion to the extracellular matrix.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Interaction partners:
- Mucin-1
- Mucin-12
- Mucin-13
- Mucin-17
- Mucin-3A
- Mucin-4
- Mucin-20
- Mucin-16
- Mucin-21
- Mucin-2
Sequence:
MLALAKILLISTLFYSLLSGSHGKENQDINTTQNIAEVFKTMENKPISLESEANLNSDKENITTSNLKASHSPPLNLPNNSHGITDFSSNSSAEHSLGSLKPTSTISTSPPLIHSFVSKVPWNAPIADEDLLPISAHPNATPALSSENFTWSLVNDTVKTPDNSSITVSILSSEPTSPSVTPLIVEPSGWLTTNSDSFTGFTPYQEKTTLQPTLKFTNNSKLFPNTSDPQKENRNTGIVFGAILGAILGVSLLTLVGYLLCGKRKTDSFSHRRLYDDRNEPVLRLDNAPEPYDVSFGNSSYYNPTLNDSAMPESEENARDGIPMDDIPPLRTSV
Protein: Baculoviral IAP repeat-containing protein 5.1-A (Bir1-A protein) (Survivin/XBIR1) (XBIR1) (Survivin1-a) (XSurvivin1) (XSurvivin1A) (Xsvv1) (xSurvivin) (Q8JGN5)
Organism: Xenopus laevis (African clawed frog)
Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Stimulates the mitotic kinase activity of aurkb/aurora-B in the CPC. Does not appear to exhibit anti-apoptotic activity.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O15392}. Nucleus {ECO:0000269|PubMed:12464631}. Chromosome {ECO:0000269|PubMed:12464631}. Chromosome, centromere {ECO:0000269|PubMed:12464631}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12464631}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. {ECO:0000250|UniProtKB:O15392, ECO:0000269|PubMed:12464631}.
Interaction partners:
Sequence:
MYSAKNRFVQAVQRLQDFKNMYDYDARLATFADWPFTENCKCTPESMAKAGFVHCPTENEPDVACCFFCLKELEGWEPDDDPWTEHSKRSANCGFLSLTKCVNDLTMEGFLRLEGDRIKSFYRKFSTVVLQYVEEEMTAATKRLLEYFSNQHHCSIDLDH
Protein: Mitogen-activated protein kinase (EC 2.7.11.24) (Q7ZW72)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MATAAVSAPAGGGPNPGSGAEMVRGQAFDVGPRYSNLSYIGGGAYGMVCSAYDRDNKVRVAIKKISPFEHQTYCQRTLREIKILLRFKHENIIGINDIIRTPTIDQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINIKARNYLLSLPLRSKVPWNRLFPNADPKALDLLDKMLTFNPHKRIEVEEALAHPYLEQYYDPTDEPVAEAPFKFDMELDDLPKETLKELIFEETARFQPGYRP
Protein: Zinc metalloprotease mde10 (EC 3.4.24.-) (Meiotically up-regulated gene 139 protein) (Sporulation protein mde10) (O13766)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in the development of the spore envelope.
Subcellular location: Endoplasmic reticulum. Spore wall. Note=Endoplasmic reticulum during meiosis. Located at the spore rim at the end of meiosis.
Interaction partners:
- Spore wall structural constituent isp3
- Probable sphingolipid long chain base-responsive protein pil2
- Ascus wall endo-1,3-alpha-glucanase
- Uncharacterized protein C63.14
- Protein scd2/ral3
- mRNA export factor crp79
- Ascus wall glucan endo-1,3-beta-D-glucosidase
Sequence:
MRLVLLFSCVLAVSSYAEIILAHSDENLLSRTKNNLSKWNENRLYDYGSKSTMSLPVSSLFPALQTLWIGVVADCSYVTHFTSRMEAKKHIFQEFEGVSTLYEDSFNINVQIHSLILPSAHDCSANVVDRPEISMSPRISIEEKLEIFSKWKYESPGNNVFEAISPHERESFPSEPQVSVLFTSSVKRSPHGVSWFATICSETHIENEWHVGPLSVVSAYPNDRLVVAHEIGHILGLIHDCNKKSCGDHSEACCPLSSSLCDAQELYIMNPSNSYTYANLRFSDCSILQLHSLVEKKYVSLSCLSKPSEKSVLRLGTCGNGIVEDGEECDCGEDCENNPCCDGKTCKLTKGSLCDDQQDACCYQCHFKNAGTLCRQSTNPCDKPEFCTGISSKCPVDENWDDGRICQDSLGMGSCASGVCTSASRQCKKLTNFSSLSCHSDSCKVSCQNEDGTCFISAKDYIDGTRCRGGLCYNGVCVPIEGSSASWSKQPSLFCASGTMLISLAVIAWFFW
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q1JPZ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAEGELNVDSLISRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANNLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDESLMCSFQILKPSEKKAKYQYSGVNSGRPVTPPRTAQAPKKR
Protein: General transcription factor IIIC subunit 5 (Q5T7U4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTRAIYADPTKRLELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRQKGVLGTEAHSEVTFDMEILGIISTIYKFQGMSDFQYLAVHTEAGGKHTSMYDKVLMLRPEKEAFFHQELPLYIPPPIFSRLDAPVDYFYRPETQHREGYNNPPISGENLIGLSRARRPHNAIFVNFEDEEVPKQPLEAAAQTWRRVCTNPVDRKVEEELRKLFDIRPIWSRNAVKANISVHPDKLKVLLPFIAYYM
Protein: RE44143p (Q8MYY9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYKDKDTYVTAAYRKKLESIRQMQEQEQRDEYLEAIGDVTKQKDLDGFYRHLYEQKLGGPAQQDVVKPKTAPTTDEVAYKPIKAEAVKHRSYRRRRPSEDEEEQTKSKSDAASDATKSTDQTESIPAQAHLTNNIDADSDFSIDDSSDEEDEKENEKEKNKLSQIKKEDKDKAPESSEPVKPKEPEASQQSPTKKDDSNAEVNEKDLPVPRVTKPPVDRTLFWRKRTVGEVLAAALARYEERKRARLQ
Protein: PsqB (Q7JP00)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00320}.
Interaction partners:
Sequence:
MTSLGMGMNGGLLGVPMGFLDFTPEPPAPSATPVTVTEHVDLSCNPSTDTRDLSNTTEPLDIDNHLAQQIHRLDQSPMHSISHHHTGDESNSNLVQHIKSEVIEAKHLAAQHHALSQAQQQHAHHQAHQQHQQHQQQQHQQQQQHLHAQQLLAQSQLQQQQQQQQQQQQHHQQQQQQAAAAAAAAGVHGQHGGHVTHADIGGATVMEIDPSQIKHEPGMIITPEIVNMMSSGHMDMYNSDTSEDSMMIANGSPHDQKEPHYTNLDQQHGLGGSVCGPGPGGAGGGGGMSGGAGSGSGEKGQFNGPKAWTQDDMNSALDALKNQNMSLTKASAIYGIPSTTLWQRAHRMGIETPKKEGGTKSWNEDALQNALEALRSGQISANKASKAFGIPSSTLYKIARREGIRLAAPFNAAPTTWTPEDLERALEAIRAGNTSVQKASAEFGIPTGTLYGRCKREGIELSRSNPTPWSEDAMNEALNSVRVGQMSINQAAIHYNLPYSSLYGRFKRGKYDVVANTSGVALLNTSGNTTGSIEIIEHSQENSLHMLQQQFPYSPSPHPPTPQHHSTPQHHSSAQQGPPTPQHMQQHVVHMQQQQQQQQQQQSPHPGHHPQHMQQDVVTSSSQVVHSQQQQQLQQIYQHHGTPERS
Protein: Taste receptor type 1 member 1 (G-protein coupled receptor 70) (Q9Z0R8)
Organism: Rattus norvegicus (Rat)
Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Taste receptor type 1 member 3
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Transient receptor potential cation channel, subfamily M, member 5
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Polycystin 2 like 1, transient receptor potential cation channel
Sequence:
MLFWAAHLLLSLQLVYCWAFSCQRTESSPGFSLPGDFLLAGLFSLHGDCLQVRHRPLVTSCDRPDSFNGHGYHLFQAMRFTVEEINNSSALLPNITLGYELYDVCSESANVYATLRVLALQGPRHIEIQKDLRNHSSKVVAFIGPDNTDHAVTTAALLGPFLMPLVSYEASSVVLSAKRKFPSFLRTVPSDRHQVEVMVQLLQSFGWVWISLIGSYGDYGQLGVQALEELAVPRGICVAFKDIVPFSARVGDPRMQSMMQHLAQARTTVVVVFSNRHLARVFFRSVVLANLTGKVWVASEDWAISTYITSVTGIQGIGTVLGVAVQQRQVPGLKEFEESYVRAVTAAPSACPEGSWCSTNQLCRECHTFTTRNMPTLGAFSMSAAYRVYEAVYAVAHGLHQLLGCTSEICSRGPVYPWQLLQQIYKVNFLLHENTVAFDDNGDTLGYYDIIAWDWNGPEWTFEIIGSASLSPVHLDINKTKIQWHGKNNQVPVSVCTTDCLAGHHRVVVGSHHCCFECVPCEAGTFLNMSELHICQPCGTEEWAPKESTTCFPRTVEFLAWHEPISLVLIAANTLLLLLLVGTAGLFAWHFHTPVVRSAGGRLCFLMLGSLVAGSCSFYSFFGEPTVPACLLRQPLFSLGFAIFLSCLTIRSFQLVIIFKFSTKVPTFYRTWAQNHGAGLFVIVSSTVHLLICLTWLVMWTPRPTREYQRFPHLVILECTEVNSVGFLLAFTHNILLSISTFVCSYLGKELPENYNEAKCVTFSLLLNFVSWIAFFTMASIYQGSYLPAVNVLAGLTTLSGGFSGYFLPKCYVILCRPELNNTEHFQASIQDYTRRCGTT
Protein: Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) (O94776)
Organism: Homo sapiens (Human)
Function: May function as a transcriptional coregulator. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}.
Interaction partners:
- Histone deacetylase 2
- Transcriptional repressor p66-alpha
- Histone deacetylase 1
- Histone-binding protein RBBP7
- Histone-binding protein RBBP4
- Chromodomain-helicase-DNA-binding protein 3
- Chromodomain-helicase-DNA-binding protein 4
- Metastasis-associated protein MTA1
- Transcriptional repressor p66-beta
- Methyl-CpG-binding domain protein 3
Sequence:
MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVCLFRRRDISSSLNSLADSNAREFEEESKQPGVSEQQRHQLKHRELFLSRQFESLPATHIRGKCSVTLLNETDILSQYLEKEDCFFYSLVFDPVQKTLLADQGEIRVGCKYQAEIPDRLVEGESDNRNQQKMEMKVWDPDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQRNGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKTTDRYIQQKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRLCASCWIYWKKYGGLKTPTQLEGATRGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMAGAGVPFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPASTNEPIVLED
Protein: Defective in cullin neddylation protein 1 (Q9U3C8)
Organism: Caenorhabditis elegans
Function: Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes.
Subcellular location: Nucleus {ECO:0000269|PubMed:15988528}.
Interaction partners:
- NEDD8-conjugating enzyme ubc-12
- RING-box protein 1
- Ubiquitin-like protein NEDD8
- Cullin-1
- Cullin-3
- Cullin-4
- COP9 signalosome complex subunit 5
- RING-box protein 2
- Cullin-5
- Cullin-6
Sequence:
MNRLKSDQKTKLRQFVQWTQVTEAVSLNFLAKANWNIEYAMTLYFDNPNLFAGSTPQPSVDRSNIERLFNQYVDPKDKVGEKRMGPHGINRLLTDLGYEATDRRVLVLAWKFTAQTQCEFSLDEWVKGMTALQADTVQNLRQRIDSINSGLESDKAKFHELYLFAFNYAKSAACRNLDLETAICCWDVLFGQRSTIMTQWIDFLWAQENAAASRLAQNVGASNAKQFKSVWISRDTWNLFWDFILLSKPDLSDYDDEGAWPVLIDQFVDYCRENLNYPKPGNASNDQQMETPSYY
Protein: Calcium-dependent protein kinase 10 (EC 2.7.11.1) (Calcium-dependent protein kinase isoform CDPK1) (AtCDPK1) (Q9M9V8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger. May be a positive regulator controlling stress signal transduction.
Subcellular location: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- 17.6 kDa class II heat shock protein
- Respiratory burst oxidase homolog protein D
- Respiratory burst oxidase homolog protein B
- Respiratory burst oxidase homolog protein A
- Calcium-binding protein CP1
- Respiratory burst oxidase homolog protein F
- Protein NLP7
- Protein NLP6
- Respiratory burst oxidase homolog protein E
- Probable respiratory burst oxidase homolog protein I
Sequence:
MGNCNACVRPDSKESKPSSKPKKPNRDRKLNPFAGDFTRSPAPIRVLKDVIPMSNQTQISDKYILGRELGRGEFGITYLCTDRETHEALACKSISKRKLRTAVDIEDVRREVAIMSTLPEHPNVVKLKASYEDNENVHLVMELCEGGELFDRIVARGHYTERAAAAVARTIAEVVMMCHSNGVMHRDLKPENFLFANKKENSPLKAIDFGLSVFFKPGDKFTEIVGSPYYMAPEVLKRDYGPGVDVWSAGVIIYILLCGVPPFWAETEQGVALAILRGVLDFKRDPWPQISESAKSLVKQMLDPDPTKRLTAQQVLAHPWIQNAKKAPNVPLGDIVRSRLKQFSMMNRFKKKVLRVIAEHLSIQEVEVIKNMFSLMDDDKDGKITYPELKAGLQKVGSQLGEPEIKMLMEVADVDGNGFLDYGEFVAVIIHLQKIENDELFKLAFMFFDKDGSTYIELDELREALADELGEPDASVLSDIMREVDTDKDGRINYDEFVTMMKAGTDWRKASRQYSRERFKSLSINLMKDGSLHLHDALTGQTVPV
Protein: Adenylate kinase 2, chloroplastic (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase 2) (AMK2) (Q9FIJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Plays a major role in the equilibration of adenylates and de novo synthesis of ADP in the plastid stroma.
Subcellular location: Plastid, chloroplast stroma {ECO:0000305|PubMed:18162585}.
Interaction partners:
- Adenylosuccinate lyase
- Adenylosuccinate lyase
- Probable adenylate kinase 7, mitochondrial
- Adenosine kinase 1
- Adenosine kinase 2
- AMP deaminase
- At5g66005
- Thiamine pyrophosphokinase 2
- Thiamine pyrophosphokinase 1
- 5'-nucleotidase
Sequence:
MTGCVNSISPPPVTLYRHRASPSRSSFSLSGDALHSLYRHRRVSRSPSIIAPKFQIVAAEKSEPLKIMISGAPASGKGTQCELITHKYGLVHISAGDLLRAEIASGSENGRRAKEHMEKGQLVPDEIVVMMVKDRLSQTDSEQKGWLLDGYPRSASQATALKGFGFQPDLFIVLEVPEEILIERVVGRRLDPVTGKIYHLKYSPPETEEIAVRLTQRFDDTEEKAKLRLKTHNQNVSDVLSMYDDITIKIEGNRSKEEVFAQIDSSLSELLQERNTAPSSLLS
Protein: Response regulator (RmpA2) (Q53343)
Organism: Klebsiella pneumoniae
Interaction partners:
Sequence:
MEKYIYFMCNKDVTLVLTDDYYFYFGLKQLTGLPLVYITYEGSMDKPIVIKQKRNIRVLVDSRIFYSGKWDGYKMLRKTLNMISQWMWLDISGGGEKFYPKGCDYDIYVNMQGNLKKNIEELYYAYLKKNVSRIGNHYPQLTKKEQIILQCLLSRREGIHELKSRLKIEEKTLSCHRCKITRKFGCKRFIRFMYLYNLNKEITDEKWCTSNT
Protein: Paralemmin-1 (Paralemmin) (A0A087WTK8)
Organism: Homo sapiens (Human)
Subcellular location: Apicolateral cell membrane {ECO:0000256|ARBA:ARBA00037796}; Lipid-anchor {ECO:0000256|ARBA:ARBA00037796}. Basolateral cell membrane {ECO:0000256|ARBA:ARBA00037871}; Lipid-anchor {ECO:0000256|ARBA:ARBA00037871}. Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}. Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium membrane {ECO:0000256|ARBA:ARBA00004527}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004527}.
Interaction partners:
Sequence:
MNYKRVSNTPLRTVDGSPMMKAAMYSVEITVEKDKVTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSEVDELIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPGQEPPVTMIFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEPKEPAPPNGSAAEPPTEAASREENQAGPEATTSDPQDLDMKKHRCKCCSIM
Protein: Sodium-dependent nutrient amino acid transporter 1 (B4MEG2)
Organism: Drosophila virilis (Fruit fly)
Function: Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MELKTMPQNGANAGTQHNNNSNNKPDNNEKEAQKKEPERTNWSNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIIGQFTSQGTVKIWSICPSFMGVGYGQAFATICIITYYSSLLALTVYYLFVSFQSELPWSYCRDDWVNCVNSRPAEYVETLLTNASSALSRATESATNVTKLQSSSELYFLNVVIKEKSDITDGIGAPDWKLTIALFVSWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFALLGRAVTLEGAVDGIIFFLQPQWGELLNPIVWKEAVVQCFFSLAVGCGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLKVDNIRDVVRSGTGLAFISYPDAISKFQAVPQLFSALFFFMLFVLGIGSIVALQSTIVTIICDQFKTCKYWKVAMATSICGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWIYGLQNFCDDIEFMSNKKVSLYWRICWSFFTPIMMIVIFIYSMVTISPIKYSDTYFPVAGDVAGWVLFAVGAAQFPLWGWWYIRTHRHDSFSKSFMASLKPSEKWGPSNPETRRDWLLFKSDLAAKRAIQAKSNKMGFFRQKLYNLCGNSN
Protein: Homeobox protein ceh-34 (Q94165)
Organism: Caenorhabditis elegans
Function: Acts as a transcription regulator. Binds to the sequence motif 5'-TCAGGTT-3'. Binds to the cis-regulatory element of proapoptotic factor egl-1 gene and together with eya-1 activates egl-1 expression to promote motor neuron M4 sister cell apoptosis. Also promotes apoptosis of I1 pharyngeal neuron sister cell. Together with eya-1, required to specify the coelomocyte fate in embryonic and postembryonic precursors.
Subcellular location: Nucleus {ECO:0000269|PubMed:19427847, ECO:0000269|PubMed:20713707}.
Interaction partners:
- Protein phosphatase eya-1
- Dachshund homolog dac-1
- Homeobox protein mab-5
- Forkhead box protein F
- HABP4_PAI-RBP1 domain-containing protein
Sequence:
MQQSYNPQNSLTATTSYSEQEIVCICESLFNEGLQTGRTEQLANFIYNLPQCYQVMESVLKAQALVYFTTQNWKMLYKLLECSKFSPHNHTVLQNLWLDAHYKEAAKTKDRELGAVCKYRIRKKNPFPNTIWDGEETNYCFKSKSRNVLRDAYKKCQYPSVEDKRRLAQQTELSIIQVSNWFKNKRQRERAAGQLDRSSARSNDSDDGSSGCESKPPMNIDSPAPPPLPTSFDLQPYYPSPYTFAPHCDFSYIQNL
Protein: Repressor, PtrA (Q9I035)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Copper-resistant cuproprotein CopI
- Two-component response regulator, CopR
- Sensor protein
- Tyrosine porin OpdT
- NADPH-dependent 7-cyano-7-deazaguanine reductase
- Copper resistance protein A
- Repressor, PtrB
Sequence:
MRTFTASTLAFLLVLAPTVPAMADSGGDIVFERMQAQAAKARAAHQEKLAKQAEATKKDKENC
Protein: Zinc finger protein 287 (Zfp-287) (Zinc finger protein SKAT-2) (Q9EQB9)
Organism: Mus musculus (Mouse)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MANSSLSQVLLMWKPGKIQKGPCSAEQQTLTSRLLRDTETCRRNFRNFPYPDVAGPRKALCQLRELCLKWLRPEVHSKEQILELLVLEQFLSILPGEVRTWVNSQYPESSEEVVALVEDLTQILEEEEAPQSSALPQDTPEDDPNHDPNPASQAGWLSDVVTKDLVTFNDVAVDITQEDWELMPPVQKELYKTVTLQNYWNMVSLGLTVYRPTVIPVLEEPWMVIKEIVEGPNPEWEPKAQAQCPAKHLPELKQDGTQTVKLEDSYDDDNDDSVESPPVCAFGMIHIDEEGFSVKSELSQEDPTEEYLSKCDIYRVTFEKHTNLGVQFDTQSDDKTALYNESKPPFSNASSGGAVRGKILPGDKPYSCNVCGKQFRKYPSLLAHRENHAKEKAYECEECGKEFKHLSSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCEDCGKDFSQRAHLTIHQRTHTGEKPYKCLECSKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYKCTACGKAFAHSSTLIQHQTTHTGEKSYICNVCGKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNTCGKAYRQGANLTQHQRVHTGEKPYKCHHCGKAFIYSSSLNQHRRTHTGERPYKCSHCNKDFSQRTCLIQHQRIHTGEKPYGCRICGKAFTQSTNLIQHQRVHTGARHRN
Protein: Cystatin cpi-1 (P90698)
Organism: Brugia malayi (Filarial nematode worm)
Function: Cysteine protease inhibitor which inhibits members of the peptidase C1 family (By similarity). Does not inhibit asparaginyl endopeptidase.
Interaction partners:
Sequence:
MFFPIVWLSVLLIISKSFAREIRLSRATYNEDDEEIQEVAEKAMEQVNDQTRYRNLYKLVRVISAQTQVVAGIKYYLTILAAPTTCRKGAVGMNPMKCTIDSSKPTKQFKIEVWSAPWQNTFKVTLT
Protein: Glutaredoxin (Q54GP8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity). Affects the culmination and cell fate decision by modulating the levels of reduced glutathione.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Thioredoxin-3
- Ribonucleoside-diphosphate reductase large subunit
- Type-1 glutamine synthetase 1
Sequence:
MDKVKALIKAHKLIIFSKTTCPYCISVKDLFKKLKVVPFVVELDLESDGSELQSAAGQISGVRTVPQVFINEKFIGGCDATTKLHSQGKLIPLLQEAGFL
Protein: Cytochrome P450 4F4 (CYPIVF4) (Leukotriene-B4 20-monooxygenase) (EC 1.14.14.94) (P51869)
Organism: Rattus norvegicus (Rat)
Function: A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its oxygenated derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Hydroxylates the terminal carbon (omega-hydroxylation) of inflammatory lipid mediators, including prostaglandin (PG) A1, PGE1 and leukotriene B4 (LTB4), and may play a role in inactivation of these oxylipins during the resolution of inflammation.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000255}. Microsome membrane; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 2D26
- Long-chain fatty acid transport protein 5
- Hepatic sodium/bile acid cotransporter
Sequence:
MPQLDLSWLGLRLETSLPWLLLLLIGASWLLVRVLTQTYIFYRTYQHLCDFPQPPKWNWFLGHLGMITPTEQGLKQVTKLVATYPQGFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFYSFLKPWLGDGLLLSDGDKWSCHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLASGGSARLDMFKNISLMTLDSLQKCVFSFDSNCQEKPSEYISAILELSALVAKRYQQLLLHTDSLYQLTHNGRRFHKACKLVHNFTDAVIQGRRRALPSQHEDDILKAKARSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDRESTEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEPLSTQ