wanglab/gogpt-training-data huggingface dataset:
Protein: NUF2 component of NDC80 kinetochore complex (E9PKH1)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome, centromere {ECO:0000256|ARBA:ARBA00004584}.
Interaction partners:
Sequence:
METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRFLSGI
Protein: Centriolar coiled coil protein 110kDa, isoform B (Centriolar coiled coil protein 110kDa, isoform D) (Centriolar coiled coil protein 110kDa, isoform H) (Q2PDW6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Centrosomal protein of 97 kDa
- Serine/threonine-protein kinase PLK4
- Centrosomal protein 135kDa, isoform B
- Spindle assembly abnormal 4
- Spindle assembly abnormal protein 6 homolog
- Centrosomal protein Cep290
- Anastral spindle 1, isoform A
- Anastral spindle 2, isoform A
- BcDNA.LD24702
- Ubiquitin carboxyl-terminal hydrolase
Sequence:
MDATWAMEQLLSAVEMGGSHSEATTPTATTTISIWSAPSEGSGSSSMDPVSFRFHLDGQPILPPLMTSAKKREVQLARQMAEALEKRYRLARHSAGSDMASRRSVSQLQQTETLIYDSTRGQARPQTLVFGKQLPTIQVDPPTPQPFVKSIENTSPRRHNRITDRILQFEQSGLGKLLPKVPDKCILRTSPAVAEDQQDQDTKDTTARELGSPLAEPANFQRSRSFTLEEPSQVLVEHMEREALAVKPSQSLANFEKQTIESQAKRVNRSARSISSKISHNSYNSNSSAATKSTIATKTTTAGSSCSRRDREVERIIERALDEHGALEASRKAGVRNYLRGHRERMNQLVIHQEKERRRMQAEFDHQQRQLIEELCAEIDVSSATENPDSLISQSTSTGDLQRFSPSPTLPSFSEDIEDFPTMEDKCQIAGPSSARKRLFSPKPSKDSEPQLLSAPSTPRSLPLRNSSLTNSRRSVQVVRRRSQSVGGSLVKTITAADREVKKSPAKPGGGAGRPKSSPGKNSSIIAKRGSAPPKSASPTKRLGNKYVELKQEERQWAATRINAGVRGFLVRRLFATEQVQRIVQTIRDTLIFVLNLHLETCGHGLDAEEPANLRLKARLLQQLCSASRTLHLIFFQTNIKDRMEIIARDRQRIKTKLLLKHRRLD
Protein: Myosin-3 (Actin-dependent myosin-I MYO3) (Class I unconventional myosin MYO3) (Type I myosin MYO3) (P36006)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.
Subcellular location: Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:17522383}. Note=Localizes to cortical patch-like protein structures that assemble actin patches. Enriched at sites of polarized growth.
Interaction partners:
- Verprolin
- Proline-rich protein LAS17
- Protein BZZ1
- Myosin tail region-interacting protein MTI1
- Calmodulin
- Actin-binding protein
- Myosin-5
- Reduced viability upon starvation protein 167
- SWI5-dependent HO expression protein 4
- Actin
Sequence:
MAVIKKGARRKDVKEPKKRSAKIKKATFDANKKKEVGISDLTLLSKISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDLGIYTNAVLESYKGKNRLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASNSHSESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQRVVGQIKNERNFHIFYQFTKGASDTYKQMFGVQMPEQYIYTAAAGCTTADTIDDVKDYEGTLEAMRTIGLVQEEQDQIFRMLAAILWIGNISFIENEEGNAQVGDTSVTDFVAYLLQVDASLLVKCLVERIMQTSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFPGADKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVCDLIEAKNPPGILAAMNDSIATAHADSNAADQAFAQRLNLFNSNPYFELRANKFVIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFPDDVDKDSKRRPPTAGDKIIKSANELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFYLLSPDCSYAGDYTWDGDTLEAVKLILRDAMIPEKEFQLGVTSVFIKTPESLFALEDMRDKYWYNMAARIQRAWRRFLQRRIDAAIKIQRTIREKKGGNKYVKLRDYGTKLLAGKKERRSMSLLGYRAFMGDYLSCNESKTKGSYIRRQVGIKDKVVFSIKGECLHSKFGRSAQRLKKVFILTKKTFYIIGQTREQNAMKYTQDYKIDVGKIKQVSLTNLQDDWMGVILVNSTQSDPLINTPFKTELMTRLKKLNEKIMIKVGPTIEYHKQPNKLHTVRSKISDSAPKYGDIYKSSTIYVRRGHPANSKSNKKPKNPGGLSGKPIKSKKSKHKSTHKHTHSHRSHRDAAKKQPLPSQKPVNPLSLAATAAQAAYNPKPDKTVPIKSSAIPAAKVSSKHSSKPSSKEKVAVKKASSSHKSSSAKQNQVSMPPSKGVEKNKEPLKETTATATANIPIPPPPPPMGQPKDPKFEAAYDFPGSGSSSELPLKKGDIVFISRDEPSGWSLAKLLDGSKEGWVPTAYMTPYKDTRNTVPVAATGAVNDVTNQKSSQIDNTISSAQEGVQFGSATVGPTSDNQSNPVGTFSDGLASALAARANKMRAESADDDDNDDGDDDDDW
Protein: SWR1-complex protein 4 (Q8VZL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.
Subcellular location: Nucleus {ECO:0000269|Ref.5}.
Interaction partners:
- RuvB-like protein 1
- Actin-related protein 4
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- RuvB-like helicase
- SWR1 complex subunit 2
- Transcription initiation factor TFIID subunit 14b
- SWR1 complex subunit 6
- Transcription initiation factor TFIID subunit 14
- Phosphotransferases/inositol or phosphatidylinositol kinase
- Histone acetyltransferase subunit NuA4-domain protein
Sequence:
MGGTDAKDILGLPKTPLSLTQEKKSRPQKESHRKPDGISREVYALTGGVAPLMPSIDLKRRPPADEKVAWKWLSFTNSARKDDLQLYHWVRVVNDVPPTGDYSFAKYNKSVDILKYTDEEYENHLTDSVWTKEETDQLFEFCQNFDLRFVVIADRFPVSRTVEELKDRYYSVNRALLRARAQSPADVANHPLMKEPYDITRDRERKRALSMVLSQSRHQEKKDAEILAEAKRITEMRLAARRAEEPDVSANENAGLDKADGVVPGRSVSPTSNSQLPATAVAPSTLTMADYASTLASLRMLHVYLRTYGLEQMVQAASSAVGLRTIKRVEQTLQDLGVNLKPKVPTKTVCDEHLELRKEILTLLNLQKQLQYKESEGSSHREGSYAAMPDTPKDRVFAPDPFSFGAERPIKKEQKRKGPGRQADTPSPAHKRPRKLKASDL
Protein: Divergent protein kinase domain 1A (Protein FAM69A) (Q5T7M9)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D6I7}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9D6I7}.
Interaction partners:
Sequence:
MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGKCLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKAKLGDQGNLSELVNLILTVADGDKDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKLMGFCGDLYVMESVEYTSLYGISLPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLLEFVEDVFHGPYGNFLMCDTSAKNLGYNDKYDLKMVDMRKIVPETNLKELIKDRHCESDLDCVYGTDCRTSCDQSTMKCTSEVIQPNLAKACQLLKDYLLRGAPSEIREELEKQLYSCIALKVTANQMEMEHSLILNNLKTLLWKKISYTNDS
Protein: Interferon-related developmental regulator 1 (IRPR) (Nerve growth factor-inducible protein PC4) (P20695)
Organism: Rattus norvegicus (Rat)
Function: Probably participates in neurogenesis. Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8028043}. Cell membrane {ECO:0000269|PubMed:8028043}. Nucleus {ECO:0000269|PubMed:8028043}. Note=Presents a NGF-dependent pattern of intracellular localization. With increasing amounts of NGF and besides being expressed in the cytoplasm, it is also localized in the plasma membrane (inner side) at the onset of NGF-induced differentiation, from where it disappears to reappear in the nuclei of differentiated cells.
Interaction partners:
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Ubiquitin-like protein FUBI
- Histone deacetylase 1
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL18
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MPKNKKRNAPHRGGGGGGGSGAATSAATTGGPHRTVQPFSDEDASIETMSHCSGYSDPSSFAEDGPEVLDEEGTQEDLEYKLKGLIDLTLDKSAKTRQAALEGVKNALSSKVLYEFVLERRMTLTDSIERCLKKGKSDGQRAAAALASVLCIQLGPGLESEEILKTLGPILKKIICDGTASIQARQTCATCFGVCCFIATDDITELYSTLECLEGIFTKSYLKEKDTNVPCSTPNTVLHISSLLAWTLLLTICPISEVKKKLELHFHKLPSLLSCDDVNMRIAAGESLALLFELARGMESDFFYEDMDSLTQMLRALATDGNKHRAKVDKRKQRSVFRDVLRAVEERDFPTETVKFGPERMYIDSWVKKHTYDTFKEALGSGMQYHLQTNEFLRNVFELGPPVMLDAATLKTMKIPRFERHLYNSAAFKARTKARSKCRDKRADVGEFF
Protein: Molybdate/tungstate transport system permease protein WtpB (O30143)
Organism: Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Function: Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for the translocation of the substrate across the membrane (Probable).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Molybdate/tungstate import ATP-binding protein WtpC
- Molybdate/tungstate-binding protein WtpA
- Molybdate/tungstate import ATP-binding protein WtpC
- Probable adenylyl-sulfate kinase
- Nitrate ABC transporter, ATP-binding protein
- Ferredoxin-nitrite reductase
- ABC transporter, ATP-binding protein
- Nitrate ABC transporter, ATP-binding protein
- Glutamine ABC transporter, ATP-binding protein
- Molybdate/tungstate import ATP-binding protein WtpC
Sequence:
MRLLFSALLALLSSIILLFVLLPVAATVTLQLFNFDEFLKAASDPAVWKVVLTTYYAALISTLIAVIFGTPLAYILARKSFPGKSVVEGIVDLPVVIPHTVAGIALLVVFGSSGLIGSFSPLKFVDALPGIVVAMLFVSVPIYINQAKEGFASVDVRLEHVARTLGSSPLRVFFTVSLPLSVRHIVAGAIMSWARGISEFGAVVVIAYYPMIAPTLIYERYLSEGLSAAMPVAAILILLSLAVFVALRIIVGREDVSEGQG
Protein: WRKY transcription factor 28 (WRKY DNA-binding protein 28) (Q8VWJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein SAR DEFICIENT 1
- Transcription factor TCP8
- Isochorismate synthase 1, chloroplastic
- Calmodulin-binding protein 60 G
- 4-substituted benzoates-glutamate ligase GH3.12
Sequence:
MSNETRDLYNYQYPSSFSLHEMMNLPTSNPSSYGNLPSQNGFNPSTYSFTDCLQSSPAAYESLLQKTFGLSPSSSEVFNSSIDQEPNRDVTNDVINGGACNETETRVSPSNSSSSEADHPGEDSGKSRRKRELVGEEDQISKKVGKTKKTEVKKQREPRVSFMTKSEVDHLEDGYRWRKYGQKAVKNSPYPRSYYRCTTQKCNVKKRVERSFQDPTVVITTYEGQHNHPIPTNLRGSSAAAAMFSADLMTPRSFAHDMFRTAAYTNGGSVAAALDYGYGQSGYGSVNSNPSSHQVYHQGGEYELLREIFPSIFFKQEP
Protein: Cyclin-SDS (Protein SOLO DANCERS) (Q1PFW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Meiosis-specific cyclin. Required for normal homolog synapsis and recombination in early to mid-prophase 1. May regulate the timing of sister chromatid separation.
Interaction partners:
- Cyclin-dependent kinase A-1
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase B2-2
- Wee1-like protein kinase
- Meiosis-specific protein ASY1
- Cyclin-dependent kinase B1-2
- 2-oxoglutarate
- Major latex-like protein
- Cyclin-dependent kinase F-1
- Cell division cycle 20.3, cofactor of APC complex
Sequence:
MKEIAMRNSKRKPEPTPFAGKKLRSTRLRRKRAQISPVLVQSPLWSKQIGVSAASVDSCSDLLADDNVSCGSSRVEKSSNPKKTLIEEVEVSKPGYNVKETIGDSKFRRITRSYSKLHKEKEGDEIEVSESSCVDSNSGAGLRRLNVKGNKINDNDEISFSRSDVTFAGHVSNSRSLNFESENKESDVVSVISGVEYCSKFGSVTGGADNEEIEISKPSSFVEADSSLGSAKELKPELEIVGCVSDLACSEKFSEEVSDSLDDESSEQRSEIYSQYSDFDYSDYTPSIFFDSGSEFSEKSSSDSPISHSRSLYLQFKEQFCRSTIPNDFGSSCEEEIHSELLRFDDEEVEESYLRLRERERSHAYMRDCAKAYCSRMDNTGLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERTLILVGIASLTLATRIEENQPYNSIRKRNFTIQNLRYSRHEVVAMEWLVQEVLNFKCFTPTIFNFLWFYLKAARANPEVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLACIEHNKISAYQRVIKVHVRTTDNELPECVKSLDWLLGQ
Protein: DNaJ domain (Prokaryotic heat shock protein) (O45502)
Organism: Caenorhabditis elegans
Interaction partners:
- Heat shock protein 70
- DUF148 domain-containing protein
- Heat shock protein hsp-1
- Heat shock protein 110
- Stress-induced-phosphoprotein 1
- Heat shock protein 90
- Heat shock protein 70
- DnaJ homolog subfamily B member 13
- Endoplasmic reticulum chaperone BiP homolog
- Heat shock protein hsp-6
Sequence:
MVKETGYYDVLGVKPDASDNELKKAYRKMALKFHPDKNPDGAEQFKQISQAYEVLSDEKKRQIYDQGGEEALQGGGGGGEGFHNPFDVFDMFFGGGGRGGRGERRVKPTVHNLRVTLDTLYKGVTKKLKISRTATCKGCKGLGGNEGSAKECSDCRGRGIKVRVIRMGPMVQQMQSHCDSCNGEGSTFLEKDRCKKCNGKKQVKEDEIIEVGITPGMKDGEKFVFEGKGDEVIGIEKPGDFVVVLDEVEHEKFVRKGDNLIIQHNIDLSEALCGFVRTISTLDGRTIFYRVLPGEVIAHADVKVIHNEGMPMRRASSDKGDLLVQFDVKFPDKINPDAAKKLADLLPGKREEIIDEDAEVVELTELDPQASRRNFAERDDFEGHGGFGGHGHGPQGVQCQQS
Protein: Uncharacterized protein (Q38CB0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPAVCQSLISGYEEENQYLLVEAIHIQRELKHCGAEPIATDPCVRMFPKQYASPLQMLRRTENQPIALSSELLNTWGGTTRQDRKECYCQPKLLSANYCRVEPYCNNKVARPQLPSAFGGKGSLFPSIAARLENDVALGLAASLWPSGNVVGHCDDRLAHLLVLSSTIVRCKKIAQRDCEKLGGVAAARGVSSELRCEYMKAIEHLVYLERSVTETILLVPPNLGVSQERLPCRGGAALQDSVAKSHTSKGTSVELSVSILSAVRVLKGLIEPATLTDRATSNPTWQYSLVRTAADVPSRYDIVDAMSYTLEPYPGLAVPRIYCAVARQLALEILRSAGNGSIGDRAAVAALRILQHINTRTECLCSEEREAGQRFLSRLQWRLQRLTQMLASEVVDEATLPTRELVAATRMFCGDPPVDFS
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q9XI67)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquitin fusion degradation UFD1 family protein
- DBH-like monooxygenase
- At2g29070
- Probable E3 ubiquitin-protein ligase RHA1A
- Membrane-anchored ubiquitin-fold protein 4
- Putative ubiquitin-dependent proteolytic protein
- Probable aspartyl protease At4g16563
- U-box domain-containing protein 45
- At1g14330/F14L17_7
- Arabidopsis thaliana genomic DNA, chromosome 5, P1 clone:MOK16
Sequence:
MSSENDFVEFSSMFERIIQGRGDGLSRFLPVIVALAAREDDDDQGSTDQTTRRGDPLSPRFVMIGSRSGLDDFFSDGGKQGRSPALKSEVENMPRVVIGEDKEKYGGSCAICLDEWSKGDVAAEMPCKHKFHSKCVEEWLGRHATCPMCRYEMPVEEVEEEKKIGIWIGFSINAGDRRN
Protein: Exo-poly-alpha-D-galacturonosidase (EC 3.2.1.-) (E0SDX9)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Interaction partners:
- Pectinesterase A
- Pectin acetylesterase
- Xylosidase/arabinosidase
- 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
- Pectate lyase
- Pectinesterase B
- Oligogalacturonate lyase
Sequence:
MKRCFTYGVIMHKGVAFSLLASCALASVAAQAAEKVAFPDRVCNVTRYGAEGHRLQIALNTESFQKAIDECAAAGGGTVLVPAGNYLVEPLFLKSNVRLHLEKNATLVASTGENAYRATDSTRYAEAENGWLPFISIADAQNVAITGEGTIDGQGAVWWERWRAAIRATGKKGGTDRPRLIYVTRSNRVLIDGVTLTNSPSFHVVMRYAHDVTVNGTHIIAPWHAPNTDAIDPIDSQNIRITNNVIDCNDDHIAIKAEKPDSRFPNGVVDNIYIANNVLKQGRGISIGSETSGGVNNVLVENNRFEGSMYGIRIKSLRGKGGEVKNVTYRHTRMLDVEVPLVFSGYYQAAPIVQAEVDKLLQAGGFTLGEQIYPPDTEPAQPFDKVKTPHFSQVTIVDLESTGRSKAAGYIIGVPEAPLSGFHFEQVRIDAEKGLRVRNAELAAKGLTLNVKQGDALLLDKGANVTR
Protein: Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI) (Q924M7)
Organism: Mus musculus (Mouse)
Function: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12122025}.
Interaction partners:
- Glucose-6-phosphate isomerase
- Phosphomannomutase 2
- Hexokinase-1
- Hexokinase HKDC1
- Hexokinase-3
- Hexokinase-2
- Glutamine--fructose-6-phosphate aminotransferase 1
- Phosphomannomutase 1
- Glucosamine-6-phosphate deaminase 1
- ATP-dependent 6-phosphofructokinase, muscle type
Sequence:
MASPRVFPLSCVVQQYAWGKVGSKSEVACLLASSDPLAQISEDKPYAELWMGTHPRGDAKILDNRISQKTLGQWIAENPDCLGSKVKNTFNGKLPFLFKVLSVDTALSIQAHPNKELAEKLHLQAPEHYPDANHKPEMAIALTSFQGLCGFRPVEEIVTFMKKVPEFQLLIGDDATAQLKESVGGDTEAMASALRNCFSHLMKSEKKVVVEQLNLLVKRISQQVFDGNNMEDIYGKLLLQLHQQHPGDIGCFAIYFLNLLTLKPGEAMFLDANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLNYTPSPSNNRLFAPAQSQDDPYLSIYDPPVPDFTVMKMEVPSSVTEYKVSTLDSASILLMVQGTVTAIIPSAHAEIPLYRGGVLFIAANESVLLKITVPKDLLIFRACCLL
Protein: Pregnancy-specific beta-1-glycoprotein 9 (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9) (PS34) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (Pregnancy-specific beta-1-glycoprotein 11) (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific glycoprotein 7) (PSG7) (Q00887)
Organism: Homo sapiens (Human)
Function: Binds to the small latent transforming growth factor-beta complex, consisting of the N-terminal TGFB1 latency-associated peptide (LAP) and the mature form of TGFB1, thereby leading to the activation of TGFB1. The activation of TGFB1 leads to stimulation of naive CD4(+) T-cells to increase FoxP3 expression and to an increase in the number of FoxP3(+) regulatory T-cells. Induces the differentiation of a suppressive CD4(+)LAP(+)FoxP3(-) T-cell subset. Induces the secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells. May reduce the expression of several pro-inflammatory cytokines and chemokines by CD4(+) T-cells, including IL2 and IL6.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Pregnancy-specific beta-1-glycoprotein 3
- Pregnancy-specific beta-1-glycoprotein 1
- Transforming growth factor beta-1 proprotein
- Pregnancy-specific beta-1-glycoprotein 6
- Pregnancy-specific beta-1-glycoprotein 4
- Chorionic somatomammotropin hormone 1
- Chorionic somatomammotropin hormone 2
- Pregnancy specific beta-1-glycoprotein 7
- Pregnancy-specific beta-1-glycoprotein 2
Sequence:
MGPLPAPSCTQRITWKGLLLTASLLNFWNPPTTAEVTIEAQPPKVSEGKDVLLLVHNLPQNLPGYFWYKGEMTDLYHYIISYIVDGKIIIYGPAYSGRETVYSNASLLIQNVTRKDAGTYTLHIIKRGDETREEIRHFTFTLYLETPKPYISSSNLNPREAMEAVRLICDPETLDASYLWWMNGQSLPVTHRLQLSKTNRTLYLFGVTKYIAGPYECEIRNPVSASRSDPVTLNLLPKLPIPYITINNLNPRENKDVLAFTCEPKSENYTYIWWLNGQSLPVSPGVKRPIENRILILPSVTRNETGPYQCEIRDRYGGLRSNPVILNVLYGPDLPRIYPSFTYYRSGENLDLSCFTESNPPAEYFWTINGKFQQSGQKLFIPQITRNHSGLYACSVHNSATGKEISKSMTVKVSGPCHGDLTESQS
Protein: S-phase kinase associated protein 2 (A0A0A0MTL5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLGHPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPVLPGITSQINYLKSELQNLLLGDPNLNKGQIRGFGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL
Protein: Transposon Ty1-PR2 Gag-Pol polyprotein (Gag-Pol-p199) (TY1A-TY1B) (Transposon Ty1 TYA-TYB polyprotein) (p190) [Cleaved into: Capsid protein (CA) (Gag-p45) (p54); Ty1 protease (PR) (EC 3.4.23.-) (Pol-p20) (p23); Integrase (IN) (Pol-p71) (p84) (p90); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Pol-p63) (p60)] (P0C2J0)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRPITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMNTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
Protein: Transport and Golgi organization protein 2 (Q9VYA8)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play a role in Golgi organization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16452979}. Mitochondrion {ECO:0000250|UniProtKB:P54797}. Golgi apparatus {ECO:0000269|PubMed:16452979}.
Interaction partners:
- Large ribosomal subunit protein mL40
- Zinc finger DHHC-type containing 8, isoform E
- Citrate transport protein
- Ubiquitin fusion degradation protein 1 homolog
Sequence:
MCVIFFCADSNPQPGGYKLILASNRDEFFARATLSAAKWANADHVYGGIDLEPGREGGTWLAIGHSAGFFKVGALLNLTGEPKPRDAVGRGMIVADYVTRADEEHSILNYNERLLKDCTKYSAFNFVSIEIGSASQPARVKLLSNVPPTLEDFQNGECYGFGNSLPHSPFEKVRHGKQEFEAIVKAHGEASVETLSAQLMQLLRNKHKFWPDDELKTRAPNWGEGLSSLNVHIEEHAYGSRTHSVVLVDSENKMHFIEETMTGLDPHGEWNKTHIEKDFQNGV
Protein: Hsp90 co-chaperone Cdc37-like 1 (B1AL69)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEQPWPPPGPWSLPRAEGEAEEESDFDVFPSSPRCPQLPGGGAQMYSHGIELACQKQKEFVKSSVACKWNLAEAQQKLGSLALHNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQREKMCLWSTDAISKDVFNKSFINQDKRKDTEDEDKSESFMQKYEQKIRHFGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQAPRF
Protein: Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Virus-induced-signaling adapter) (VISA) (Q8VCF0)
Organism: Mus musculus (Mouse)
Function: Adapter required for innate immune defense against viruses. Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (By similarity). May activate the same pathways following detection of extracellular dsRNA by TLR3 (By similarity). May protect cells from apoptosis (By similarity). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q7Z434}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q7Z434}. Mitochondrion {ECO:0000269|PubMed:23582325}. Peroxisome {ECO:0000250|UniProtKB:Q7Z434}.
Interaction partners:
- NLR family member X1
- TNF receptor-associated factor 3
- TNF receptor-associated factor 6
- Antiviral innate immune response receptor RIG-I
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon
- Serine/threonine-protein kinase TBK1
- Interferon-induced helicase C domain-containing protein 1
- TNF receptor-associated factor 2
- Autophagy protein 5
- Ubiquitin-like protein ATG12
Sequence:
MTFAEDKTYKYIRDNHSKFCCVDVLEILPYLSCLTASDQDRLRASYRQIGNRDTLWGLFNNLQRRPGWVEVFIRALQICELPGLADQVTRVYQSYLPPGTSLRSLEPLQLPDFPAAVSGPSAFAPGHNIPDHGLRETPSCPKPVQDTQPPESPVENSEQLLQTNSGAVARMSGGSLIPSPNQQALSPQPSREHQEQEPELGGAHAANVASVPIATYGPVSPTVSFQPLPRTALRTNLLSGVTVSALSADTSLSSSSTGSAFAKGAGDQAKAATCFSTTLTNSVTTSSVPSPRLVPVKTMSSKLPLSSKSTAAMTSTVLTNTAPSKLPSNSVYAGTVPSRVPASVAKAPANTIPPERNSKQAKETPEGPATKVTTGGNQTGPNSSIRSLHSGPEMSKPGVLVSQLDEPFSACSVDLAISPSSSLVSEPNHGPEENEYSSFRIQVDESPSADLLGSPEPLATQQPQEEEEHCASSMPWAKWLGATSALLAVFLAVMLYRSRRLAQ