wanglab/gogpt-training-data huggingface dataset:
Protein: Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)] (O94964)
Organism: Homo sapiens (Human)
Function: Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:33587225}. Golgi apparatus membrane {ECO:0000250|UniProtKB:E1U8D0}. Midbody {ECO:0000269|PubMed:33587225}. Note=Associates with microtubules during late mitosis and interphase. {ECO:0000269|PubMed:33587225}.; SUBCELLULAR LOCATION: [C-terminal 80 kDa form]: Secreted {ECO:0000250|UniProtKB:E1U8D0}. Note=Secreted in primary hepatocyte-conditioned media. {ECO:0000250|UniProtKB:E1U8D0}.
Interaction partners:
Sequence:
MEAPAAEPPVRGCGPQPAPAPAPAPERKKSHRAPSPARPKDVAGWSLAKGRRGPGPGSAVACSAAFSSRPDKKGRAVAPGARGAGVRVAGVRTGVRAKGRPRSGAGPRPPPPPPSLTDSSSEVSDCASEEARLLGLELALSSDAESAAGGPAGVRTGQPAQPAPSAQQPPRPPASPDEPSVAASSVGSSRLPLSASLAFSDLTEEMLDCGPSGLVRELEELRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSSEPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPVVHDKEGKIIIEPGFLFTTAKPKESAEADGLAESSYGRWLCNFSRQRLDGGSAGSPSAAGPGFPAALHDFEMSGNMSDDMKEITNCVRQAMRSGSLERKVKSTSSQTVGLASVGTQTIRTVSVGLQTDPPRSSLHGKAWSPRSSSLVSVRSKQISSSLDKVHSRIERPCCSPKYGSPKLQRRSVSKLDSSKDRSLWNLHQGKQNGSAWARSTTTRDSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSETRAKPEPPKYGIVQEFFRNVCGRAPSPTSSAGEEGTKKPEPLSPASYHQPEGVARILNKKAAKLGSSEEVRLTMLPQVGKDGVLRDGDGAVVLPNEDAVCDCSTQSLTSCFARSSRSAIRHSPSKCRLHPSESSWGGEERALPPSE
Protein: Tripartite motif-containing 55 (EC 2.3.2.27) (Muscle-specific RING finger protein 2) (MuRF-2) (MuRF2) (G3X8Y1)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000269|PubMed:29435413}. Cytoplasm {ECO:0000269|PubMed:29435413}. Note=TLR4 signaling pathway promotes nuclear translocation. {ECO:0000269|PubMed:29435413}.
Interaction partners:
- Titin
Sequence:
MSTSLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKLDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLEDTCKTIEECCRKQKQDLCEKFDHLYGILEERKTEMTQAITRTQEEKLEHVRTLIRKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLQKIVEASKAFQMEKLEQGYEIMSNFTVNLNREEKIIREIDFSREEEEEEDAGEIDEEGEGEDAVEVEEAENVQIASSGEEESLEKAAEPSQLPAELQVAPEPLPASSPEPFSSMPPAADVLVTQGEVVPIGSQQTTQSETSGPSAAETADPLFYPSWYKGQSRKTSSNPPCTHGSEGLGQIGPLGIEDSSVQSAEVAEAATNEQAAVSGKESSSTAATSQIGFEAPSPQGQSAALGSGGGADPEPARHVFSFSWLNSLNE
Protein: UV excision repair protein RAD23 (K7EQ16)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU367049}. Cytoplasm {ECO:0000256|RuleBase:RU367049}.
Interaction partners:
Sequence:
IPGSPEPEHGSVQESQVSEQPATEAGENPLEFLRDQPQFQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRHQEQFIQMLNEPPGELADISDVEGEVGAIGEEAPQMNYIQLKALGFPESLVIQAYFACEKNENLAANFLLSQNFDDE
Protein: Golgi pH regulator homolog (Protein GPR89) (Q54QM5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein.
Interaction partners:
- Oxysterol-binding protein 4
Sequence:
MDTFTIEEIVKFDGGGGGISTINSNNDNIGIPSNTFEMIISTIQHFLDRSSSVASTIAVFVLSFILFFMFGWFYFLKILFRDYEVKKVFVQLSFSITFALSLTLFELIFFEIMDFMDREWRYRFWEFDLTLMSINLILVLPYYQFYLLVLAYGFSKRKTLFFSLVLLVLYLILFWKIGDPFPILKEYTGLVSLEMGIGRIGIVGCTVMSLLSGYGAVYVPYSYITYFLKPVKDVTITKLEKQFNHALDKIFNKKKRVVLLKRELTRRNVNNNNNNNNNYDTYNYNNNYNNNSNNNNNNNNSNNNNNNNLPIIGPIFSKIYNLWNVGYHHQLSRPIDDIKQLEREIKQLEDLNRDLFTQIHELKLERLRIQFSTTLRGKFYNWLGYFFSIYWKKKSALNIVFDRRGGMDPVTRGLDIALRYFHFQVDVTFWSQHISFILVGLMTASSIRGFLNQILKVFHEYSSSLSSNNIVLILAQVMGMYFISSVLMMRTSMPEIYTRFIVTQILGDIEFSFYHRWFDFIFIPSAIITTLALIFMSKSSTFHLNDE
Protein: Mitochondrial ribonuclease P protein 1 homolog (Mitochondrial RNase P protein 1) (EC 2.1.1.-) (Protein roswell) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (tRNA methyltransferase 10 homolog C) (Q7JUX9)
Organism: Drosophila melanogaster (Fruit fly)
Function: May function in mitochondrial tRNA maturation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:27131785, ECO:0000269|PubMed:34199774}.
Interaction partners:
- Mitochondrial ribonuclease P catalytic subunit
- 3-hydroxyacyl-CoA dehydrogenase type-2
- Ribonuclease 3
- Endoribonuclease Dcr-2
- Transcription initiation factor TFIID subunit 11
- LD23072p
- Protein argonaute-1
- LD06392p
- Protein argonaute-2
- Probable ribosome production factor 1
Sequence:
MLKHFARWRLGSQLLKGCAAPVRQASKTSSAENLIAGTEEPQKKFVNPFSQPAPALSNDTISENKEERDKRLKVLQLEADIAHQEGRRVPSLEFFKDHHWEHVLTLPTKSARIKYFGYLWQIEMKKEADQRKKAERAKEAERRVAEMRKEREENTHIIYGLGHTSLFLRIYDTTINHWQNNRLTRAMQFAPKMVLDCSYDEHMNNREATYAAKQLMMCFAENRMNDEPFDLHYCNTQMDSRCMQSLQRYIPTMHNPEFPINLHSKCFTELFPKQNLVYLTPHCREDLVTYNPDDIYIVGAMVDTMNNEPLSLAKAKRLGLRMARLPLDRYLQWGSGSGKSLTLNQMINIMLDLKKTGDWDTALKHVPRRKVVQNEFQPRREKDHWSTGTRARKLNMRIDHLFDFDENRRQATSYATPQNVRQRREGLEFQLDTWATGKQKKKQRQN
Protein: MADS-box transcription factor PHERES 1 (Agamous-like MADS-box protein AGL37) (O80805)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in the development of gametophytes and seeds.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
- Agamous-like MADS-box protein AGL62
- Agamous-like MADS-box protein AGL28
- Histone-lysine N-methyltransferase MEDEA
- Agamous-like MADS-box protein AGL61
- Homeobox-leucine zipper protein HDG6
- Agamous-like MADS-box protein AGL23
- Homeobox-leucine zipper protein HDG3
- Transcriptional activator DEMETER
- Homeobox-leucine zipper protein HDG9
Sequence:
MRGKMKLSFIENDSVRKTTFTKRKKGMLKKFNELVTLCGVDACAVIRSPYNSIQEPWPSREGVEEVMSKFMEFSVLDRTKKMVDQETFLRQRIAKETERLQKLRDENRNSQIRDLMFGCLKGEVDVSHLHGRDLLDLNVFLNKYLNGVIRRVEILKENGESSSSVPPPIGVAPTVVDASVPIGFDGRMIQDQNQNQQEPVQFQYQALYDFYDQIPKKLHDFNMKMNIDPNQSMNLDLNDGEDEGIPCMDNNNYHPEIDCLATVTTAPTDVCAPNIINDL
Protein: WD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17) (Q8IWB7)
Organism: Homo sapiens (Human)
Function: Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines.
Subcellular location: Early endosome {ECO:0000269|PubMed:11739631, ECO:0000269|PubMed:25736436}.
Interaction partners:
Sequence:
MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDRTSLATFHEGKHNISHMSMDIARGLMVTCGTDRIVKIWDMTPVVGCSLATGFSPH
Protein: Putative rRNA methyltransferase (EC 2.1.1.-) (2'-O-ribose RNA methyltransferase SPB1 homolog) (F4JTD2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus, nucleolus {ECO:0000256|HAMAP-Rule:MF_03163}.
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- Probable rRNA-processing protein EBP2 homolog
- Transducin/WD40 repeat-like superfamily protein
- Pescadillo homolog
- Ribosome biogenesis protein WDR12 homolog
- Protein MAK16 homolog
- Protein REBELOTE
- Nucleolar complex-associated protein 2
- At4g01560
- Ribosome assembly factor mrt4
Sequence:
MGKVKGKHRLDKYYRLAKERGFRSRASYKLLQLDAKYSLLHSAHAVLDLCAAPGGWMQVAVEKVPVGSLVLGIDLVPILPVRGCVTMTQDITRTECKSKIKQVMEQHGVSAFNLVLHDGSPNVGGAWAQEAMSQNALVIDSVRLATEFLARNGNLVTKVFRSRDYNSVLYCLGRLFEKVEVFKPPASRSASAETYLVGLKYLAPAKIDPRLLDYRHLFKESAEPTRKVVDVLGGSKQKRNRDGYEDGESILRRVASAADFIWSENPLDVLGTTTSISFDDQASLPLKEHDLTTEEIKILCDDLPVLGKNDFKHILKWRMQIRKALTPEKKEVAKPEPDVGKEDEENEDDKLLNELEELTNTVDRKKKQAKKILAKRRAKDKARKATGPQMDVLEDGFVDNELFSLNAIKGKKDLMAVDNDEDDNGNAVDSENEDHGEGASDDSKDSDRDSDEERQKYTEQMEEIFEQAYERYMVKKEGSAKQRKRARQAHAEKLEEGDGDEEMKIDYDSDMNEEKDEANPLVVPLDDGVVQTKEEISNQWFSQNIFAEAVEEGDLGKDDSEDEIANKKKSKNLSKPDKSKQKASKASVLSDQSLPNSSKKEDEFEVVPAPATDSDSDSSSEDDVHTKAEILACAKKMLRKKQREQMLDDAYNKHMFVDEGLPKWFVDDEKQHRQPMKPVTKDEVNAMKAQFKEINARPAKKVAEAKARKKRAAQKRLEKVRKKANTISDTADISDRSKDKMIDKLYKKAAEPRKPRKELVVSKKGVGVKVGKGQKRVDRRMKSDDRKRGGGKPGRNGQKGTGKAGQKGKRPAGKPRGRKPG
Protein: YEATS domain-containing protein (Q21501)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00376}.
Interaction partners:
- DNA methyltransferase 1-associated protein 1
- Mortality factor related protein 1
- Chromatin modification-related protein MEAF6
- Enhancer of polycomb-like protein
- RuvB-like 1
- HIT-type domain-containing protein
- Vacuolar protein sorting-associated protein 72 homolog
- Uncharacterized protein
- Histone H2A.V
- RuvB-like 2
Sequence:
MTEIVERMKKKNIVKPIVYGNTATPFGYKRDSDQHTHQWTVFLKPYLIEDPTKWIRKVQFKLHESYAVPYRVVEKPPYEVTETGWGEFEIQIRIYFVDPNEKPITAFHYLRLFQPTIELPSGNQIVCMEFYDEIIFQEPTVQMYKALQASDGKRPDKQAFLNDIEQVKTRTRELGEVAQKEIAAEIEDLRESLKDAHKMIVKYNTELAEQE
Protein: Meiotically up-regulated gene 117 protein (Q9Y7V0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for correct meiotic chromosome segregation. Appears to also have role in sporulation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MWKFCCVTEKLTLFLFIYGICIYICIAVPIRSDLSTVFEPEAKGSRITSNYRRSLFNMLGYDNSVHPNNCKGSFLCPMLRGENRACPNAYMKYNRSLIYHGYSSYTASSCTAIYECEGDYPARTGNEIIDEFDQLNLQCSACGTRFFNNDNENTRCYVKLNYCYPDCTEITPSTSEYDYREPVRDW
Protein: Zinc finger protein 787 (TTF-I-interacting peptide 20) (Q6DD87)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Vesicle transport protein SEC20
- Centromere/kinetochore protein zw10 homolog
- RAD50-interacting protein 1
- Syntaxin-18
- Conserved oligomeric Golgi complex subunit 4
- Vacuolar protein sorting-associated protein 53 homolog
Sequence:
MELREEAWSPGPLDSEDQQMASHENPVDILIMDDDDVPSWPPTKLSPPQSAPPAGPPPRPRPPAPYICNECGKSFSHWSKLTRHQRTHTGERPNACADCGKTFSQSSHLVQHRRIHTGEKPYACLECGKRFSWSSNLMQHQRIHTGEKPYTCPDCGRSFTQSKSLAKHRRSHSGLKPFVCPRCGRGFSQPKSLARHLRLHPELSGPGVAAKVLAASVRRAKGPEEAVAADGEIAIPVGDGEGIIVVGAPGEGAAAAAAMAGAGAKAAGPRSRRAPAPKPYVCLECGKGFGHGAGLLAHQRAQHGDGLGAAGGEEPAHICVECGEGFVQGAALRRHKKIHAVGAPSVCSSCGQSYYRAGGEEEDDDDEAAGGRCPECRGGEGR
Protein: Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) (Q9WU00)
Organism: Mus musculus (Mouse)
Function: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Peroxisome proliferator-activated receptor gamma coactivator 1-beta
- Transcription factor A, mitochondrial
- Forkhead box protein O3
- NAD-dependent protein deacetylase sirtuin-1
- Nuclear factor erythroid 2-related factor 2
- Steroid hormone receptor ERR1
- NAD-dependent protein deacetylase sirtuin-7
Sequence:
MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATTTHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANGLVQIPVSMYQTVVTSLAQGNGPVQVAMAPVTTRISDSAVTMDGQAVEVVTLEQ
Protein: Insulin-like growth factor 1 (Insulin-like growth factor I) (IGF-I) (Somatomedin) (Q02815)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MSSGHFFQWHLCDVFKSAMCCVSCTHTLSLLLCVLTLTSAATGAGPETLCGAELVDTLQFVCGERGFYFSKPTGYGPSSRRSHNRGIVDECCFQSCELRRLEMYCAPVKSGKAARSVRAQRHTDMPRTPKVSTAVQSVDRGTERRTAQHPDKTKPKKEVHQKNSSRGNTGGRNYRM
Protein: Filament protein FIN1 (Filaments in between nuclei protein 1) (Q03898)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Forms cell-cycle specific filaments between the spindle pole bodies of dividing yeast cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:11929974}. Cytoplasm {ECO:0000269|PubMed:11929974}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11929974}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11929974}. Note=Nuclear during early bud formation, located at the spindle poles during late mitosis, very low abundance in resting cells.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-2
- Cyclin-dependent kinase 1
- Protein BMH2
- Anaphase spindle elongation protein
- Kinetochore-associated protein DSN1
- Protein phosphatase 1 regulatory subunit SDS22
- S-phase entry cyclin-5
- Tyrosine-protein phosphatase CDC14
- Protein REG2
- Serine/threonine-protein phosphatase 1 regulatory subunit GAC1
Sequence:
MSNKSNRRSLRDIGNTIGRNNIPSDKDNVFVRLSMSPLRTTSQKEFLKPPMRISPNKTDGMKHSIQVTPRRIMSPECLKGYVSKETQSLDRPQFKNSNKNVKIQNSDHITNIIFPTSPTKLTFSNENKIGGDGSLTRIRARFKNGLMSPERIQQQQQQHILPSDAKSNTDLCSNTELKDAPFENDLPRAKLKGKNLLVELKKEEEDVGNGIESLTKSNTKLNSMLANEGKIHKASFQKSVKFKLPDNIVTEETVELKEIKDLLLQMLRRQREIESRLSNIELQLTEIPKHK
Protein: PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) (Q9Y5B6)
Organism: Homo sapiens (Human)
Function: Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P58501}.
Interaction partners:
- Serine/Arginine-related protein 53
- U5 small nuclear ribonucleoprotein 40 kDa protein
- Probable ATP-dependent RNA helicase DDX23
- Synaptojanin-1
Sequence:
MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPGPSPPSALTPGLGAEAGGGFPGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTYQTMPYGSSYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGKMADHLEGLSSDDEETSTDITNFNLEKDRISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYGCEEREQEKDDVDVALLPTIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPSVVNAENKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAMSVASDHNVKEFKSLIEGK
Protein: Hippocampus abundant transcript 1 protein (Major facilitator superfamily domain-containing 14A) (P70187)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- UDP-N-acetylglucosamine transporter
- Major facilitator superfamily domain-containing protein 3
Sequence:
MTQGKKKKRAANRSIMLAKKIIIKDGGTPQGIGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQHHFEQNSIIPGPPFLFGACSVLLALLVALFIPEHTNLSLRSSSWRKHCGSHSHPHSTQAPGEAKEPLLQDTNV
Protein: MIF4G domain containing (J3QLJ5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGEPSREEYKIQSFDAETQQLLKTALKDPGAVDLEKVANVIVDHSLQDCVFSKEAGRMCYAIIQAESKQAGQSVFRRGLLNRLQQEYQAREQLRARSLQGWVCYVTFICNIFDYLRVNNMPMMALVNPVYDCLFRLAQPDSLSKEEEVGGPSPGTSTEGCRMDSPAQPCVSPLLTEVDCLVLQLHRVGEQLEKMNGQRMDELFVLIRDGFLLPTGLSSLAQLLLLEIIEFRAAGWKTTPAAHKYYYSEVSD
Protein: Adenylate-forming reductase cicB (EC 1.2.1.-) (Cichorine biosynthesis cluster protein B) (Nonribosomal peptide synthase-like protein cicB) (NRPS-like protein cicB) (A0A1U8QW91)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Nonribosomal peptide synthase-like protein; part of the gene cluster that mediates the biosynthesis of cichorine, a phytotoxin active against knapweed, corn, and soybeans. The first step in the pathway is performed by the non-reducing polyketide synthase pkbA that condenses one acetyl-CoA starter unit with 3 malonyl-CoA units. PkbA also catalyzes one methylation step to produce 3-methylorsellinate. The nonribosomal peptide synthase-like protein cicB, the cytochrome P450 monooxygenase cicH and the O-methyltransferase cicE are involved in the conversion of 3-methylorsellinate into nidulol. CicB converts 3-methylorsellinate to a yet unidentified intermediate, cicH may play a ring-closing role for cichorine and cicE is plausibly responsible for the methylation of one of the phenol groups (Probable). The oxidoreductase cicC acts downstream with still unidentified enzymes to further convert nidulol into cichorine.
Interaction partners:
Sequence:
MARNQQLRPFKRPAIRLYPAVNETELIRTLPEVVEFNAQANPDHVFCLQAKKSPNKSILSLVSVTNRQLKQAISQCVGWLKSNLKLQLPSLLHGSVEKGAPVALLMESDIGLFIYEIALIGLGVPVLLLSARLSAPAINSLLQRTSAAAIIVSGRLEATAREAAETLPAAVFSPLPFEAFLSTNEGLPDNDSICHPYHYIDESDRNVLILHSSGTTGLPKPIYVSHRHLLSFVNCHRLDLESEAQGVNVSTLPLYHGFGLVAPALAMGVGKTVCFPPGSTVPSAGATLDLLRISNAASFMTVPSILEDIAFLGDEGIQALAGLDYVTFGGGILKPSVGEELAVHGVKLLNHYGTTESGPLAPIFVPQDDYNWRFFRLRDDLRLQLDEIAPNGNERRFKLTTFPFGLEQPFEIQDQLVCNPDYPGSDFNAVGRNDDTIVLATGEKVQPQILESILCESSLVKSAIAFGEHQFEIGVLVQLAADVPPKNYSKLREQLWPLVARANESMDGHARIQSSEAVLLLPSTVTIPRTDKGSIARKDVYKMFEADIAGVYRKLESAGPVLCLDMETLEEDLKLLISRCTDWPPDWAVTDDLFERGMNSLQAIRVQRALVAAVTRSLRGVCQPERIGRDFVYIHPSVRAMADFFREPVNGLQLPNGFSTRGWAPDQLVQRFALTSKDGRATVLLTGATGSLGSHCLLSLIQSPNIKRVICLVRPEDSFTDPRLRLQKSLESKKLHLSSTQWSMVDVLGCHTASQYLGLTREQYTILQESVTYILHAAWPMDFHWKLPSFQSQFQSLHNLLALARDIHNRRPSIKPRLTFISSIATVGQYARVHGVRMVPETSVDSVECLNPIGYAEAKLVCERMLEHARLHYPHEMTVSYVRMGQIAGSSTTGFWNINEHIPALTLSWIPVDVAAQSITELLLSPAPAELIYHIENPIRQSWHDMLQTIAAVLHLSASDALPWNEWQEQVAAAGDTDNPAKKLQDFFANDFIRMGCGEVVLGTDKARKASATLRRVDAVSEGCVRGYLQYWKEIGWLK
Protein: Small ribosomal subunit protein eS26B (40S ribosomal protein S26-B) (Q9UTG4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS27
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein eS21
- Elongation factor 3
- mRNA export factor elf1
Sequence:
MTQKRRNNGRNKHGRGHVKFVRCINCSRAVPKDKAIKRWTIRNMVETAAIRDLSEASVYSEYTIPKLYIKLQYCVSCAIHSRVVRVRSREGRRIRTPPPRVRYNRDGKKVNPTAVAKNL
Protein: Gasdermin D (G3V1A6)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MISAHCNLHLPGSSDSLASASQLLLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH
Protein: Na(+)-translocating NADH-quinone reductase subunit D (Na(+)-NQR subunit D) (Na(+)-translocating NQR subunit D) (EC 7.2.1.1) (NQR complex subunit D) (NQR-1 subunit D) (A5F5Y6)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Function: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00428, ECO:0000305}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00428}.
Interaction partners:
Sequence:
MSSAKELKKSVLAPVLDNNPIALQVLGVCSALAVTTKLETAFVMTLAVMFVTALSNFFVSLIRNHIPNSVRIIVQMAIIASLVIVVDQILKAYLYDISKQLSVFVGLIITNCIVMGRAEAFAMKSEPIPSFIDGIGNGLGYGFVLMTVGFFRELLGSGKLFGLEVLPLISNGGWYQPNGLMLLAPSAFFLIGFMIWAIRTFKPEQVEAKE
Protein: Histone H3.3C (Histone H3.5) (Q6NXT2)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H4-like protein type G
- WD repeat-containing protein 5
- Histone H4
- Chromobox protein homolog 5
- Chromobox protein homolog 3
- Histone H2A type 2-C
- DNA
- Chromobox protein homolog 1
- DNA
- Histone H2B type 2-E
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSTPSTCGVKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFNTDLRFQSAAVGALQEASEAYLVGLLEDTNLCAIHAKRVTIMPKDIQLARRIRGERA