wanglab/gogpt-training-data huggingface dataset:
Protein: Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) (Memory-related gene 2 protein) (MRG-2) (P10860)
Organism: Rattus norvegicus (Rat)
Function: Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P00367}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P00367}. Note=Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum. {ECO:0000250|UniProtKB:P00367}.
Interaction partners:
- Delta-1-pyrroline-5-carboxylate synthase
- Glutamine synthetase
- Glutaminase liver isoform, mitochondrial
- Aspartate aminotransferase, mitochondrial
- Pyruvate carboxylase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Glutaminase kidney isoform, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Carbamoyl-phosphate synthase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
Sequence:
MYRRLGEVLLLSRAGPAALGSAAADSAALLGWARGQPSAVPQPGLTPVARRHYSEAATDREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRENEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGLGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
Protein: Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2) (Q9NZJ5)
Organism: Homo sapiens (Human)
Function: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z2B5}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes to the Localizes to endoplasmic reticulum membrane (By similarity). Also present at mitochondria-endoplasmic reticulum contact sites; where it interacts with ATAD3A (PubMed:39116259). {ECO:0000250|UniProtKB:Q9Z2B5, ECO:0000269|PubMed:39116259}.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
- Eukaryotic translation initiation factor 2 subunit 1
- Cyclic AMP-dependent transcription factor ATF-4
- Cyclic AMP-dependent transcription factor ATF-6 alpha
- Nuclear factor erythroid 2-related factor 2
- Presenilin-1
- Endoplasmin
- NF-kappa-B essential modulator
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Inhibitor of nuclear factor kappa-B kinase subunit beta
Sequence:
MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVPAAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQRTQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEEQEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNENAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN
Protein: Nonsense-mediated mRNA decay factor SMG8 (Suppressor with morphogenetic effect on genitalia protein 8) (O62301)
Organism: Caenorhabditis elegans
Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes.
Interaction partners:
- Nonsense-mediated mRNA decay factor SMG9
- Serine/threonine-protein kinase smg-1
- Nonsense-mediated mRNA decay protein
- PIN domain-containing protein
- DNA/RNA-binding domain-containing protein
- Eukaryotic peptide chain release factor subunit 1
- MIF4G domain-containing protein
- UPF3 domain-containing protein
- ATP-dependent RNA helicase DHX34
- Neuroblastoma-amplified sequence
Sequence:
MDIAKWVEHARTCYSTQLDTKIKVIGVIGKDYPDHGKGDNINCYLRENVFPVAATEDETCTIRGHFSEDDQILFLVMNGVDDVANIRKCLKSNPKSNYFDAMAESECQQIRMLHFLFISCHFIIIFEQTSRIDLELMRFLKKVNSARIQLRKKINQRLVASDLRDVSFNNRILSSAESEGRMVVPRLLIAFQRNNIRPDVNPGKKLQRELYEKLEKNLDNQFSDILKLYDLIDCGASSLCQLNETIPVVHLLNPKIVKRDIIGEMFEILMADAENTKISGNAGTLPSNNSFVKFLEDNFRSEKNEISLENVIELMNCLQCVLDGDLEEKHEKTAIQTFIKRIQNDHMEEARRLYTNAQRPGERRGADRFKDSEKPVKIRSKEEHLMRFNEATHYIDSVVGVNSREALSQLQAQCNEMWQSDMRACESVSMMGRSCVRKIHPTFGDQTAPEHRWTAHDASNTMISTCVCGRKQLIRPEPFSVKEANSDFYDHPDFKCCRRLWRYQFQLYQEDSEEKDDIMWADRESNSLRAAKKMAQREDELAEEDTDLDIPESLLDPDSTSPSDEDDVRVRTMSSSESSSQESDAYLRPTSRRDESMASKTERELTIDHVKRMQKLELAGKSEDFLITVPNSMTTGKLPIFPSWHLTSLGDSSIYSHGAGLKNQPNFKIGGDYLSPVVVLLDVNFDVWNRDLNKIRSEDFSRKCGKDNKDDSARVKLFVGFEYECSRGHRFFVDYNGEPLIYSKGSNVIRESAHRSSLGNVLQADLPIRRPCTCRKLPLQSAQLQKVHVVTPKAPVHITIDPKVLIPTHEGVYGTGQEPLELHHSKYYILHLPTVYSGPSGAWMPGEFNPEKQGVWMGGALKVAYKPVMSFKW
Protein: Major actin (EC 3.6.4.-) (Actin A1) (Actin A12) (Actin A8) (Actin III) (Actin M6) (Actin-1) (Actin-11) (Actin-12) (Actin-13) (Actin-14) (Actin-15) (Actin-16) (Actin-19) (Actin-2) (Actin-2-sub 1) (Actin-20) (Actin-21) (Actin-3a) (Actin-4) (Actin-5) (Actin-6) (Actin-7) (Actin-8) (Actin-9) (Actin-IEL1) (P07830)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Myosin IE heavy chain
- Actin-related protein 2/3 complex subunit 2
- Coactosin
- Tubulin alpha chain
- Actin-related protein 2/3 complex subunit 1
Sequence:
MDGEDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFEAEMQTAASSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPSIVHRKCF
Protein: Receptor expression-enhancing protein (Q9N4G8)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362006}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362006}.
Interaction partners:
- Reticulon-like protein
- JAKMIP_CC3 domain-containing protein
- Endoplasmic reticulum lectin 1
- Leucine-rich repeat flightless-interacting protein 2
Sequence:
MPVPPQVQKVLDDVDKQLHEPSTVTNVLATVEQKTGVKRLHLVLGVVGLQALYLIFGHSAQLVCNFMGFVYPAYMSIKAIESSNKEDDTQWLTYWVIFAILSVVEFFSVQIVAVFPVYWLFKSIFLLYLYLPSFLGAAKLYHRFVKPVAARHSGSIDAKIGNFADRVNSAAGKLANEVRDHME
Protein: Ethylene-responsive transcription factor FZP (OsERF078) (Protein BRANCHED FLORETLESS 1) (Protein FRIZZY PANICLE) (Protein FRIZZY PANICLE 2) (Q8H3Q1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Required to prevent the formation of axillary meristems within the spikelet meristem and permit the subsequent establishment of floral meristem identity. Mediates the transition from spikelet to floret meristem. Determines the transition from panicle branching to spikelet formation. May specify floral organ identity by regulating the class B genes (Agamous-like genes) MADS6 and MADS17, as well as class E genes MADS1, MADS7 and MADS8 in floral meristem. Possesses transactivation activity.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366}.
Interaction partners:
- Transcription factor LAX PANICLE 1
Sequence:
MNTRGSGSSSSSSSSQASLMAFSEPPKPASQPSPPSSPMSERPPSGRSRRRAQEPGRFLGVRRRPWGRYAAEIRDPTTKERHWLGTFDTAQEAALAYDRAALSMKGAQARTNFVYTHAAYNYPPFLAPFHAPQYAAAAAAPSSVQYGGGVGAAPHIGSYGHHHHHHHHHGHGAASGASSVGECSTMPVMVPVDPHRSSMSSSLLDMDRNGHDFLFSGADDNSGYLSSVVPESCLRPRGGGAAADHQDMRRYSDADAYGMMGLREDVDDLAQMVAGFWGGGDAADQLGACGFPASGGAADMVASSQGSDSYSPFSFLSH
Protein: Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) (P07174)
Organism: Rattus norvegicus (Rat)
Function: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. In response to proNGF binding, the heterodimeric receptor with SORCS2 activates a signaling cascade that leads to decreased Rac activity, reorganization of the actin cytoskeleton and neuronal growth cone collapse. Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20036257, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:3027580}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:P08138}. Perikaryon {ECO:0000269|PubMed:22155786}. Cell projection, growth cone {ECO:0000269|PubMed:22155786}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}.
Interaction partners:
- Beta-nerve growth factor
- Neurotrophic factor BDNF precursor form
- High affinity nerve growth factor receptor
- Sortilin
- Neurotrophin-3
- Neurotrophin-4
- Leucine rich repeat and Ig domain containing 1
- Reticulon-4 receptor
- Protein BEX3
- Melanoma-associated antigen D1
Sequence:
MRRAGAACSAMDRLRLLLLLILGVSSGGAKETCSTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDNVTFSDVVSATEPCKPCTECLGLQSMSAPCVEADDAVCRCAYGYYQDEETGHCEACSVCEVGSGLVFSCQDKQNTVCEECPEGTYSDEANHVDPCLPCTVCEDTERQLRECTPWADAECEEIPGRWIPRSTPPEGSDSTAPSTQEPEVPPEQDLVPSTVADMVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQTHTQTASGQALKGDGNLYSSLPLTKREEVEKLLNGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWGAQDSATLDALLAALRRIQRADIVESLCSESTATSPV
Protein: Protein LST4 (Lethal with SEC30 protein 4) (P34239)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in extracellular amino acid uptake. Required for the trafficking of the GAP1 nitrogen-regulated general amino acid permease from the Golgi to the plasma membrane.
Interaction partners:
- Protein LST7
- General amino-acid permease GAP1
- Protein transport protein SEC13
- Mitotic check point protein BFA1
- Mitotic check point protein BUB2
- Ubiquitin ligase-binding protein BUL1
- Ubiquitin ligase-binding protein BUL2
- Maintenance of telomere capping protein 5
- Protein MEH1
- SEH-associated protein 4
Sequence:
MLGNLLRNKTSSSGFEKSSEHSDFSSVVPNVPVYCKAASTGTTKTAAGALLDTAVNVEKPSEMLSTTSPPILDHISDDLKLKLFGSRDIPYSRPIDTLQNNGGLGTDKITSINEKTYAFRILIIEEAGQMACRNNYRDIFDYTTSKISNSMEQIRPSELKEYIFGSPVRSSDLTQCDKIRTIPNSDLVLITRIFYYTHQYNRIAISLCIPRILLPVVAESWSSISSWLTQTQKMLIGFLTKNRIMQENTGNYSNNSVIKLSNIDIRTHYPKEIEIMVQTLQKRVIPGLRSMSEIPRLFLYPETFKEFVHVWFKSIFNWIEIKDGPKLGFLPLLMAMIISDYRHTIRELKTSKIVILSGNMVVANKLLFILSALLEPKYKGQITIRRENIRSDSSAVSRNKSNNNFVDKPETELSTLTSTDNLLSRTENNSNHNYNNSNVSSNSIGSPNFHSLRKGWQIPNRRNSNTSVSVSSSESLAEVIQPSSFKSGSSSLHYLSSSISSQPGSYGSWFNKRPTISQFFQPSPSLKHNESWERLQTTAGNMQRTSSSSSLQQATSRLSLTTPQQSPSISEYDEYPWMGTPGSPNVGDVSHAPPLVKNISYKFPLKNVELKRDCQRISQDDLLDEAFERICQPSLADLNSTYEIFPGNSSYADILTTDSDIDDGLMNKPLELLPKYTMYLTHFNNFFQLQACPAGQESESRITNSMKIDLLKADYTRSLLVSLRSRDIRDVALKREFTGNNNNNSNQNIYDENFVGKRKYVLKQKTRKIFSCGKIGKLSTSLENCVNFVENSIKSAMMLYDDNGIDSELRDSEALRIFSSLVHYCNAG
Protein: Fibroblast growth factor (FGF) (Q0IIQ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSVLPSRFIYVCLHLLVLYFQLQESHQSSADFRFYIENHTRDDVSRKQVRIYQLYSRTTGKHVQILGKKINANGDDGGKYALLVVETETFGSHVRIKGQESGYYICMNKNGKIIGKPNGNSQECVFVEEYLENNYTALMSAKYRGRYLGFNRKGRPKKGSKTTQTQQEVHFMKRQPKGKEDLPEKFLFTTVTKRTRRARRLKPNPNTN
Protein: BcDNA.GH02751 (Q7KMN4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGLEILKKIRGMLSGWYSSRESETDSTDTGTGFQAQNGKGFGAGRQPENSFLSQKRRNQEENPRLIKYRRVDNSFPRLITNETAEDLIPNNSMAKRDQPQSSKRLSIFNPPVYTQHRVRNDAPHVPTPFDDEESSQRLANAGPSSRPMTYSDAVRLGHNGISESRVNGHSSHTVRREPSRLHRSILSHEMNCKDQEQYNELIRTQTNYVGSRYLKPGTPPTFQRAKAQSATSSSCSLQDNQSNITDSFPSPHGRANPELTEYAKLINRQENEENRSPAPQQPKRNASNSSASHASTISSSASSSCSTCSTCSSSDTEPMLVKDSPEVKEANEANEANEANEANETKENDAPQPTTTRIKKPDFLHRRFANCIFLRNDFAENFKARANRRQLESMHLLGIAEQQANESKDERLAYEKKLREVMFRSGAPHRPFFEIGPLEQPEEKKETKLIPLTKEDHARFQEMTTIEVTTNLIFKYNLQITTDDIFTFVDGEWLNDAIINFYMSMLTERSEKRAGELPATYAMNTFFMPRLLQAGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAIIHLRNKTIFYYDSMGRPNQPALDALVKYLHEESLDKRKQPFDMTGFVVENAQNIPRQGNSSDCGVFSCMFAEYITRDVPITFSQAEMLYFRTKMALEIADGKLWQ
Protein: Clathrin light chain (CLC) (Q9USP6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Cytoplasmic face of coated pits and vesicles. {ECO:0000250}.
Interaction partners:
- Probable clathrin heavy chain
- Endocytosis protein end4
- Epsin-1
- Uncharacterized calcium-binding protein C800.10c
- AP-2 complex subunit alpha
- Actin cytoskeleton-regulatory complex protein pan1
- Actin cytoskeleton-regulatory complex protein end3
- ENTH domain-containing protein C794.11c
- UBA domain-containing protein 7
- Cytoskeletal protein syp1
Sequence:
MSQFPALEDFDDGLVTAPVDDSKNNTDFLEREKLALGEDAGQFETPEDKDALLNFENDSEAEQTRFEQNFPPIDAEMQASGTFSAPKAPYMGQAEVHPPEDESGDPEPVRKWKEDQMKRIQERDESSKKLRESNIEKARKAIDDFYENFNDKRDKVIAKSRKEQEKLLEENESKSTGTTSWERILKLIDLSDKPEAHGRSTERFRELLISLAKDSNAPGAAGTTVSSSS
Protein: DNA damage-induced apoptosis suppressor protein (Nitric oxide-inducible gene protein) (Q8IXT1)
Organism: Homo sapiens (Human)
Function: May be an anti-apoptotic protein involved in DNA repair or cell survival.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Accumulates in the nucleus in response to stress. {ECO:0000250}.
Interaction partners:
- DNA excision repair protein ERCC-6-like
Sequence:
MNRRRKFLLASVLALQNSSFIYPSCQKCFSRIILVSKRSNCPKCGSTGESGNANYRYKLSLKVAESNKLFVITVFGSCLDTFFGLTATGLHRYIQDPNKIPETLDNDTTQNLLTKAVETCFVGQSFIFGVTNFENQPGQGSDASNFLQQCSDHKRKAKALVACQIVLPDPGIAGFTVIDYFHQLLQTFNFRKLQCDSQAPNNHLLALDHSNSDLSSIYTSDSTSDFFKSCSKDTFSKFWQPSLEFTCIVSQLTDNDDFSASEQSKAFGTLQQNRKSISIAEATGSSSCHDPIQDSWSLVSYMDKKSTAEKLGKELGLQAKELSAVHSSHHEIGVNDSNLFSLEMREPLESSNTKSFHSAVEIKNRSQHELPCFQHHGIDTPTSLQKRSACCPPSLLRLEETASSSQDGDPQIWDDLPFSESLNKFLAVLESEIAVTQADVSSRKHHVDNDIDKFHADHSRLSVTPQRTTGALHTPPIALRSSQVIVKANCSKDDFLFNCKGNLSPSVEKESQPDNKVEAVSVNHNGRDMSEYFLPNPYLSALSSSSKDLETIVTLKKTIRISPHRESDHSSLNNKYLNGCGEISVSEMNEKLTTLCYRKYNDVSDLCKLENKQYCRWSKNQDDSFTICRKLTYPLETLCNSPNRSTNTLKEMPWGHINNNVTQSYSIGYEGSYDASADLFDDIAKEMDIATEITKKSQDILLKWGTSLAESHPSESDFSLRSLSEDFIQPSQKLSLQSLSDSRHSRTCSPTPHFQSDSEYNFENSQDFVPCSQSTPISGFHQTRIHGINRAFKKPVFYSDLDGNYEKIRIFPENDKQQASPSCPKNIKTPSQKIRSPIVSGVSQPDVFNHYPFAECHETDSDEWVPPTTQKIFPSDMLGFQGIGLGKCLAAYHFPDQQELPRKKLKHIRQGTNKGLIKKKLKNMLAAVVTKKKTHKYNCKSSGWISKCPDIQVLAAPQLHPILGPDSCSEVKCCLPFSEKGPPSVCETRSAWSPELFS
Protein: Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) (P51580)
Organism: Homo sapiens (Human)
Function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.
Subcellular location: Cytoplasm.
Interaction partners:
- Inosine triphosphate pyrophosphatase
- Xanthine dehydrogenase/oxidase
- Inosine-5'-monophosphate dehydrogenase 2
- GMP synthase
- Hypoxanthine-guanine phosphoribosyltransferase
- Inosine-5'-monophosphate dehydrogenase 1
- Reduced folate transporter
- Cytochrome P450 2D6
- Nucleotide triphosphate diphosphatase NUDT15
- Gamma-glutamyl hydrolase
Sequence:
MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLYLLTEK
Protein: Leucine-rich repeat transmembrane protein FLRT1 (Fibronectin leucine rich transmembrane protein 1) (Q6RKD8)
Organism: Mus musculus (Mouse)
Function: Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16872596, ECO:0000269|PubMed:20421966, ECO:0000269|PubMed:22405201}; Single-pass membrane protein {ECO:0000269|PubMed:16872596, ECO:0000269|PubMed:21673655}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:16872596, ECO:0000305|PubMed:20421966}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16872596, ECO:0000269|PubMed:20421966}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16872596, ECO:0000269|PubMed:20421966}. Cell junction, focal adhesion {ECO:0000269|PubMed:16872596}. Secreted {ECO:0000269|PubMed:21673655}. Cell projection, neuron projection {ECO:0000269|PubMed:20421966}. Cell junction {ECO:0000269|PubMed:20421966}. Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles (PubMed:16872596, PubMed:20421966). Detected along neurites and at contacts between neurite termini and other cells (PubMed:20421966). Proteolytic cleavage gives rise to a shedded ectodomain (PubMed:21673655). {ECO:0000269|PubMed:16872596, ECO:0000269|PubMed:20421966, ECO:0000269|PubMed:21673655}.
Interaction partners:
- Netrin receptor UNC5A
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L2
Sequence:
MVVAHSAATATTTPAATVTATVVMTTATMDLRDWLFLCYGLIAFLTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPSDIPDDATTLYLQNNQINNAGIPQDLKTKVKVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVRARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFEAGSQGGAANAAAKTTVSNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGDGAKTLVIQVKPLTADSIRITWKAMLPASSFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYIICMVTMETGNTYVADETPVCAKAETADSYGPTTTLNQEQNAGPMAGLPLAGIIGGAVALVFLFLVLGAICWYVHRAGELLTRERVYNRGSRRKDDYMESGTKKDNSILEIRGPGLQMLPINPYRSKEEYVVHTIFPSNGSSLCKGAHTIGYGTTRGYREAGIPDVDYSYT
Protein: Ras-related protein Rab-11B (EC 3.6.5.2) (P46638)
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
Subcellular location: Recycling endosome membrane {ECO:0000305|PubMed:10942597}; Lipid-anchor {ECO:0000305|PubMed:10942597}; Cytoplasmic side {ECO:0000305|PubMed:10942597}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35509}; Lipid-anchor {ECO:0000250|UniProtKB:O35509}; Cytoplasmic side {ECO:0000250|UniProtKB:O35509}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q15907}; Lipid-anchor {ECO:0000250|UniProtKB:Q15907}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15907}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q15907}. Note=Colocalizes with RAB11AFIP1 on punctate vesicles. {ECO:0000250|UniProtKB:Q15907}.
Interaction partners:
- Rab11 family-interacting protein 1
- Rab11 family-interacting protein 2
- Rab11 family-interacting protein 5
- Ras-related protein Rab-11A
- TBC1 domain family member 1
- Solute carrier family 2, facilitated glucose transporter member 4
- Phosphatidylinositol 4-kinase beta
- Rab GDP dissociation inhibitor alpha
- Rab GDP dissociation inhibitor beta
- Rab11 family-interacting protein 3
Sequence:
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQRPNKLQCCQSL