wanglab/gogpt-training-data huggingface dataset:
Protein: GDNF family receptor alpha-2 (GDNF receptor alpha-2) (GDNFR-alpha-2) (GFR-alpha-2) (GDNF receptor beta) (GDNFR-beta) (Neurturin receptor alpha) (NRTNR-alpha) (NTNR-alpha) (TGF-beta-related neurotrophic factor receptor 2) (O08842)
Organism: Mus musculus (Mouse)
Function: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
Subcellular location: Cell membrane {ECO:0000305|PubMed:9182803}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:9182803}.
Interaction partners:
- Neurturin
- Artemin
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Persephin
- Glial cell line-derived neurotrophic factor
- High affinity nerve growth factor receptor
Sequence:
MILANAFCLFFFLDETLRSLASPSSPQGSELHGWRPQVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYRTITSCPADNYQACLGSYAGMIGFDMTPNYVDSNPTGIVVSPWCNCRGSGNMEEECEKFLKDFTENPCLRNAIQAFGNGTDVNMSPKGPTFSATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSIQEQGLKANNSKELSMCFTELTTNISPGSKKVIKLYSGSCRARLSTALTALPLLMVTLAQ
Protein: Macrophage galactose N-acetyl-galactosamine specific lectin 2 (A9XX86)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MTMRYENFQNLEREEKNQEMRNGDKKGGMESPKFALTVPSQSFLWRILSWTHLLLFSLGLSLLLLVVISVIGSQNSQLRRDLGTLRAILDNTTSKIKAEFQSLDSRADNFEKGISSLKVDVEDHRQELQAGRDLSQKVTSLESTLEKREQALKTDLSDLTDHVQQLETDLKALTCQLANLKNNGSEVACCPLHWTEHEGSCYWFSESEKSWPEADKYCRLENSHLVVVNSLEEQNFLQNRLANVLSWMGLTDQNGPWRWVDGTDFDKGFKYVCRLQLAPLYLGLSYLFSIFSDPRDLGGPSGNMADGQIWSAQFFIFRNWRPLQPDNWHGHMLGGGEDCAHFSYDGRWNDDVCQRHYHWICETELGKASSAHSPQLIASVP
Protein: ABC transporter C family member 9 (ABC transporter ABCC.9) (AtABCC9) (EC 7.6.2.2) (ATP-energized glutathione S-conjugate pump 9) (Glutathione S-conjugate-transporting ATPase 9) (Multidrug resistance-associated protein 9) (Q9M1C7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pump for glutathione S-conjugates.
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- ABC transporter A family member 2
- ABC transporter A family member 5
Sequence:
MFKPFGFAAETGSHLLTTQWLQLGNSLCLKERISIAMQVTFLAFFLIHLALKWFGVVRNRGSNDVEEDLKKQSITVKQSFSYNISLLCSVSILGTHCFILLLLFRDSVVSRCDSSVSVFSAEVSQSFSWLFVSVVVVKIRERRLVKFPWMLRSWWLCSFILSFSFDAHFITAKHEPLEFQDYADLTGLLASLFLLAVSIRGKTGFHLLESSGNTEPLLLGDQTEQNKKDSYSSSSPYGNATLFQRITFSWINPLFSLGYKRPLEKDDVPDIDVKDSARFCSHAFDQKLKTTKEKEGPGNAFFYNSVLRYVWRKAAINAVFAVVNASTAYIGPYLINDFVEFLSEKQSQSLNHGYLLALGFLTAKIVETVTQRQWIFGARQLGLRLRAALISHIYQKGLVLSSQSRQSHTSGEIINYMSVDVQRITDFIWYVNNIWMLPIQIFSAIYILQKHLGLGALAALVTTLMVMACNYPLTRLQRNYQSDIMNAKDDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEYDCLWKSLRLQAFTTFILWGAPSLISVVTFVTCMLMGVKLTAGAVLSALATFQMLQSPIFGLPDLLSALVQSKVSADRIASYLQQSETQKDAVEYCSKDHTELSVEIENGAFSWEPESSRPTLDDIELKVKSGMKVAVCGAVGSGKSSLLSSILGEIQKLKGTVRVSGKQAYVPQSPWILSGTIRDNILFGSMYESEKYERTVKACALIKDFELFSNGDLTEIGERGINMSGGQKQRIQIARAVYQNADIYLLDDPFSAVDAHTGRELFEDCLMGILKDKTVLYVTHQVEFLPAADLILVMQNGRVMQAGKFEELLKQNIGFEVLVGAHNEALDSILSIEKSSRNFKEGSKDDTASIAESLQTHCDSEHNISTENKKKEAKLVQDEETEKGVIGKEVYLAYLTTVKGGLLVPFIILAQSCFQMLQIASNYWMAWTAPPTAESIPKLGMGRILLVYALLAAGSSLCVLARTILVAIGGLSTAETFFSRMLCSIFRAPMSFFDSTPTGRILNRASTDQSVLDLEMAVKLGWCAFSIIQIVGTIFVMSQVAWQVCVIFIPVAVACVFYQRYYTPTARELSRMSGVERAPILHHFAESLAGATTIRAFDQRDRFISSNLVLIDSHSRPWFHVASAMEWLSFRLNLLSHFVFAFSLVLLVTLPEGVINPSIAGLGVTYGLSLNVLQATVIWNICNAENKMISVERILQYSKIPSEAPLVIDGHRPLDNWPNVGSIVFRDLQVRYAEHFPAVLKNITCEFPGGKKIGVVGRTGSGKSTLIQALFRIVEPSQGTIVIDNVDITKIGLHDLRSRLGIIPQDPALFDGTIRLNLDPLAQYTDHEIWEAIDKCQLGDVIRAKDERLDATVVENGENWSVGQRQLVCLGRVLLKKSNILVLDEATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLSDGRIAEFDSPAKLLQREDSFFSKLIKEYSLRSNHFAGSNDLLS
Protein: NPC intracellular cholesterol transporter 2 (EPI-1) (Epididymal secretory protein E1) (Niemann Pick type C2 protein homolog) (P61917)
Organism: Pan troglodytes (Chimpanzee)
Function: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:8924506}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P61916}. Lysosome {ECO:0000250|UniProtKB:P61916}. Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes. {ECO:0000250|UniProtKB:P61916}.
Interaction partners:
- Niemann-Pick disease, type C1
- NPC1 like intracellular cholesterol transporter 1
- Sterol regulatory element-binding protein cleavage-activating protein
Sequence:
MRFLAATFLLLALSTAAQAEPVQFKDCGSVDGVIKEVNVSPCPTQPCQLSKGQSYSVNVTFTSNIQSKSSKAVVHGILMGVPVPFPIPEPDGCKSGINCPIQKDKTYSYLNKLPVKSEYPSIKLVVEWQLQDDKNQSLFCWEIPVQIVSHL
Protein: Peptidase S1 domain-containing protein (Q8IP30)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDRLSILLLVLGFSRIQALFCGGSMAKECVQRNRCRIGTETGRPIIDFRGLNNGNQGCESGQTCCPKTEILQYPVQADNQPLPTECGHVNRIGVGFTITNARDIAQKGELPWMVALLDSRSRLPLGGGSLITRDVVLTSSTKTLEVPEKYLIVRAGEWDFESITEERAHEDVAIRKIVRHTNLSVENGANNAALLFLARPLKLDHHIGLICLPPPNRNFIHNRCIVSGWGKKTALDNSYMNILKKIELPLVDRSVCQTKLQGPYGKDFILDNSLICAGGEPGKDTCKGDGGAPLACPLQSDPNRYELLGIVNFGFGCGGPLPAAYTDVSQIRSWIDNCIQAEAVHYSPQLGNVGQSPAPLDRYIPNIGLETQNEVHSPVQGSLHNVVYQTGGVGYIRGMGQGTAFQGPVQVGELIPNEGTVSGGLVYDSNEIQKFNQGGIYIPHVGQGNSDNRYYPNPEIGAVPVGNPIPNEGNAFGGRGYDFNEIQKHNQGGRYIPHVGHGNGPNAPKEPLKIGGNIPNVGQGNRGNRYDLNPEIGAVPVGNPIPNEGNAFGGRGYDLNEIQKHNQGGRYIPHVGHGNGPNAPKELLKIGGNIPNVGQGNRGNIYDPNPEIGAVPVGNPIPNEGNAFGGRGYDLNEIQKHNQGGRYIPHVGHGNGPNAPKEPLKIGGNIPNVGQGNRGNIYDPNPEIGAVPVGNPIPNEGNAFGGRGYDLNEIQKHNQGGRYIPHVGHGNGPNAPKEPLKIGGNIPNVGQGNRGNRYDPNPEIGAVPVGNPIPNEGNAFGGRGYDLNEIQKHNQGGRYIPHVGHGNGPNAPKEPLKIGGNIPNVGQGNRGNRYDLNPEIGHATFGATGTGMQGNNIDNPYKNNLGDRAENELERFPLENPNRDHVIRLSDFLITTPTPSAPIKLVIEKI
Protein: HTH-type transcriptional regulatory protein TyrR (Q88EH4)
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Phenylalanine-4-hydroxylase
- Pterin-4-alpha-carbinolamine dehydratase
- RNA polymerase sigma-54 factor
- Alcohol dehydrogenase, zinc-containing
- 3-oxoadipate CoA-transferase
- Uncharacterized protein
Sequence:
MRIKVHCQNRIGILRDILNLLVEYGINVLRGEVGGDHGNAIYLHCPNLINLQFQALRPKFEAIAGVFGVKRVGLMPSERRHMELNALLGALDFPVLSIDMGGSIVAANRAAAQLLGVRVDEVPGMPLARYVEDFDLPELVRANKSRINGLRIKVKGDVFLADIAPLQSEHDDSEALAGAVLTLHRADRIGERIYNVRKQELRGFDSIFQSSRVMAAVVREARRMAPLDAPLLIEGETGTGKELLARACHLASPRGQSPLMALNCAGLPESMAETELFGYGPGAFEGARAEGKLGLLELTAGGTLFLDGVGEMSPRLQVKLLRFLQDGCFRRVGSDEEVYLDVRVICATQVDLSELCARGEFRQDLYHRLNVLSLHIPPLRECMDGLEGLVQHFLDQASRQIGCAMPRLAPAAMDKLGQYHWPGNVRQLENVLFQAVSLCDGGVVKSEHIRLPDYGVRQPLGEFSLEGDLSQIVGRFEKAVLESLMGEFPSSRALGKRLGVSHTTIANKLRDYSLNKSAD
Protein: Ranatuerin-2AVb (P86162)
Organism: Rana arvalis (Moor frog)
Function: Has antibacterial activity.
Subcellular location: Secreted {ECO:0000269|PubMed:19308951, ECO:0000269|PubMed:35820801}.
Interaction partners:
Sequence:
GLMDMVKGAAKNLFASALDTLKCKITGC
Protein: SD25546p (Structural maintenance of chromosomes 6) (Q9VCB8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Non-structural maintenance of chromosomes element 4
- Non-structural maintenance of chromosomes element 1 homolog
- Structural maintenance of chromosomes protein 5
- MAGE
- E3 SUMO-protein ligase NSE2
- PAX-interacting protein 1
- E3 SUMO-protein ligase NSE2
- Structural maintenance of chromosomes protein
- PAX-interacting protein 1
- DNA topoisomerase 2
Sequence:
MERSRRGRIRRMPSPGSESDGSTAEPTRKRSKQQFVAEAEPDFVEEETEKYANASTSQTARSRNKQARQTTLNMSQRSVNFNLTSELSIPNAFDRCGKVISMRLTNFMCHSNLFIEFGPNINFLVGNNGSGKSAVITALALGLTSSARATNRASSIQKLIKNGEVSATISITLSNSGLRPFKADIFGPHLTVVRQIRHSSSTYDLQDARGKSVSKKVSDIRRMLLCFGINVENPIFVLNQEAAREFLKELEPASNYKLLMKATQLDVCTSSLTECHALRRHFTQELEQLEKKKEMMIKHIAAEEEKLSILEDKEMVKENLQQCKTKLAWMAVTSYQNELNNLEHSIKLIENKKASLEQTTSKKESTQATMNQKLKEFEASKNQILATQKFQDERLKTAKKAVQDLLLEASQVKAKIGNAERRMREDQRSYDECEKLIGNYHADFNRVNEQREENANKIEMLKKQVVKSEEIIAQLRAEQQEIKRDITSVQERLDAVKNGRIQLHKSKQNISWEIEALSRNKSNKLSVYGEQTIQVVHALRTQYAGSNMHRMPRGPLGQYISAPNPKYRDLIENQLMHCLRSFIVGSDRERQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNKVQPTTPNTTVLIDEISCDDPVVMNYLIDILRIETVLVTESKEIAEFLTSDTENVPPNLTRVLVPNLGLEYIPSPNYAVYSTRITPARYIQKNVDDRIRQLQMEQSDLQEKEPSLEIDYMQHKKVLENTQKVISQKSTMIGQHQSRNQKAMQKIMELQNFDYQELPEYDRLKSHLADSGEKIEKCRLEREMLQEKLLSIQHRQTELESTEAEERRALEGINKKLTALDTEAGEVESKMRSLDLHYEENTRRFQKTLQLERKMLGEKETVLSELEKARTEAEKLGEFIATTQTEEKIREAISRYKSKIKQVEELNYNPEELERGLAELRDELELQSRHLAVVDSVVKKLRMAYHQRAQLFQRSRHHYFTMVQFQFEQALAMRQFKVSFETSDKEKTWKINVFPPSGNETSNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEILIGEGLEWLSRQYCFLTPQDTKVEASNLITVHKLEAPER
Protein: Penicillin-binding protein activator LpoA (PBP activator LpoA) (Lipoprotein activator of PBP from the outer membrane A) (P45464)
Organism: Escherichia coli (strain K12)
Function: Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}; Lipid-anchor {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}; Periplasmic side {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}. Note=Localizes at the sidewall of elongating cells.
Interaction partners:
- Penicillin-binding protein 1A
- Penicillin-binding protein 1B
- UPF0102 protein YraN
- Penicillin-binding protein activator LpoB
- Outer membrane lipoprotein DolP
- DnaA initiator-associating protein DiaA
- Cell division protein ZipA
- D-alanyl-D-alanine carboxypeptidase DacB
- Chaperone protein YcdY
- Peptidoglycan D,D-transpeptidase MrdA
Sequence:
MVPSTFSRLKAARCLPVVLAALIFAGCGTHTPDQSTAYMQGTAQADSAFYLQQMQQSSDDTRINWQLLAIRALVKEGKTGQAVELFNQLPQELNDAQRREKTLLAVEIKLAQKDFAGAQNLLAKITPADLEQNQQARYWQAKIDASQGRPSIDLLRALIAQEPLLGAKEKQQNIDATWQALSSMTQEQANTLVINADENILQGWLDLQRVWFDNRNDPDMMKAGIADWQKRYPNNPGAKMLPTQLVNVKAFKPASTNKIALLLPLNGQAAVFGRTIQQGFEAAKNIGTQPVAAQVAAAPAADVAEQPQPQTVDGVASPAQASVSDLTGEQPAAQPVPVSAPATSTAAVSAPANPSAELKIYDTSSQPLSQILSQVQQDGASIVVGPLLKNNVEELLKSNTPLNVLALNQPENIENRVNICYFALSPEDEARDAARHIRDQGKQAPLVLIPRSSLGDRVANAFAQEWQKLGGGTVLQQKFGSTSELRAGVNGGSGIALTGSPITLRATTDSGMTTNNPTLQTTPTDDQFTNNGGRVDAVYIVATPGEIAFIKPMIAMRNGSQSGATLYASSRSAQGTAGPDFRLEMEGLQYSEIPMLAGGNLPLMQQALSAVNNDYSLARMYAMGVDAWSLANHFSQMRQVQGFEINGNTGSLTANPDCVINRNLSWLQYQQGQVVPVS
Protein: Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1) (P22361)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11.
Subcellular location: Nucleus.
Interaction partners:
- Pterin-4-alpha-carbinolamine dehydratase
- Hepatocyte nuclear factor 4-alpha
- Hepatocyte nuclear factor 3-beta
- Hepatocyte nuclear factor 3-alpha
- Pterin-4-alpha-carbinolamine dehydratase 2
- Paired box protein Pax-4
- Hepatocyte nuclear factor 3-gamma
- Hexokinase-4
- CCAAT/enhancer-binding protein gamma
Sequence:
MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESCGGSRGDLTELPNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSSLLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQVFTSDTEASSEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSDSNGHSHLLPSNHSVIETFISTQMASSSQ
Protein: Transcription factor E2F3 (E2F-3) (O00716)
Organism: Homo sapiens (Human)
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Retinoblastoma-associated protein
- Transcription factor Dp-1
- Retinoblastoma-like protein 1
- Retinoblastoma-like protein 2
- Transcription factor E2F1
- Transcription factor Dp-2
- Cyclin-dependent kinase 2
- Cyclin-A2
- Transcription factor E2F2
- Cyclin-A1
Sequence:
MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGFAAAAAAAAAPGAYIQILTTNTSTTSCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALGRGGSGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPKTPKSPSEKTRYDTSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLEGIHLIKKKSKNNVQWMGCSLSEDGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVTYQDIRKISGLKDQTVIVVKAPPETRLEVPDSIESLQIHLASTQGPIEVYLCPEETETHSPMKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEGPFVNLLPPLLQEDYLLSLGEEEGISDLFDAYDLEKLPLVEDFMCS
Protein: COUP transcription factor 2 (Drosophila seven-up homolog/mammalian ARP-1 homolog) (Nuclear receptor subfamily 2, group F, member 2) (Q91430)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
- SRY-box transcription factor 18
- Ephrin type-B receptor 4a
- Hairy/enhancer-of-split related with YRPW motif protein 2
- Delta-like protein
- Vascular endothelial growth factor receptor 3
- Lymphatic vessel endothelial hyaluronic receptor 1b
- Neurogenic locus notch homolog protein 1
- Hairy/enhancer-of-split related with YRPW motif protein 1
- Vascular endothelial growth factor C
- Prospero homeobox 1a
Sequence:
MAMVVWRGSQDDVAETHGTLSSQTQGGLSLPTPQPGQLGLTASQVAPPTPQTPVQGPPNNNNNTQSTPTNQTTQSQSEKQQPQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPHHGQFALTNGDPLHCHSYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQ
Protein: Respiratory nitrate reductase 2 gamma chain (EC 1.7.5.1) (P0AF32)
Organism: Escherichia coli (strain K12)
Function: This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Respiratory nitrate reductase 2 beta chain
- Respiratory nitrate reductase 2 alpha chain
- Respiratory nitrate reductase 1 beta chain
- Probable nitrate reductase molybdenum cofactor assembly chaperone NarW
- Respiratory nitrate reductase 1 alpha chain
- Nitrate/nitrite transporter NarU
- Nitrate/nitrite antiporter NarK
- Nitrate reductase molybdenum cofactor assembly chaperone NarJ
- Nitrite reductase small subunit
- Nitrite reductase large subunit
Sequence:
MIQYLNVFFYDIYPYICATVFFLGSWLRYDYGQYTWRASSSQMLDKRGMVIWSNLFHIGILGIFFGHLFGMLTPHWMYAWFLPVAAKQLMAMVLGGICGVLTLIGGAGLLWRRLTNQRVRATSTTPDIIIMSILLIQCLLGLSTIPFSAQYPDGSEMMKLVGWAQSIVTFRGGSSEMLNGVAFVFRLHLVLGMTIFLLFPFTRLVHVWSAPFEYFTRRYQIVRSRR
Protein: Uncharacterized protein YNL195C (P40168)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14576278}.
Interaction partners:
- Uncharacterized plasma membrane protein YNL194C
- Protein FMP16, mitochondrial
- Phosphate metabolism protein 7
- SUR7 family protein FMP45
- Meiotic sister chromatid recombination protein 1
Sequence:
MLGLGQSAQAYASDDALNMNQAKDKTYSVPGCGRASDLKYPHRDGHSSSHEQRSGILPTECPGPTLNTGAGSIGIPGCGKVTNRVVSDYNKNARSTLANFDSSKMTEARMNSKNVPIGCQDTSDPHFNGPIDQHVPGAGSPQSQPHHIDAWNSVSSRRADNNNQDMMDPQTASSDRYNEKMMREENSGVSASSYTTKVQGYPASIPSFNQETEEKETYAYGVGDRHNVPRNQIMDETNPSANVLNATDHSISHPENKVLHK
Protein: Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase (A0A1D8PEI6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|PIRNR:PIRNR036440}.
Interaction partners:
- ornithine carbamoyltransferase
- Acetylornithine aminotransferase, mitochondrial
- Argininosuccinate lyase
- Arginine biosynthesis bifunctional protein ArgJ
- Argininosuccinate synthase
- Ornithine aminotransferase
- Adenosylmethionine-8-amino-7-oxononanoate transaminase
- Amino-acid acetyltransferase, mitochondrial
- Carbamoyl phosphate synthase arginine-specific large chain
- Histidine biosynthesis trifunctional protein
Sequence:
MIRQVNKKAISNSLFKRLSLSGSAFANITANKKSSTHQLNQKTQLANVRFYSTKSTVIQLLNNIGSKREVEQYLKYFTSVSQQQFAVIKVGGAIITQQLNELASCLAFLYHVGLYPIVLHGTGPQINELLENEGVEPEYIDGIRITNPKTMEVVRKCFLEQNLRLVTALEKIGVHARPITAGVFEAEYLDKDKYQLVGKITSVNKSPIEAAINSGYLPILTSLAETSSGQLLNVNADVAAGELAREFEPLKIVYLNEKGGIINGNTGEKVSAINLDEEYEDLLKESWVKYGTKLKIKEIHDLLQHLPRSSSVAIIDVNDLQKELFTDSGAGTLIRRGYRLINRNSLRDFGNPDLLRNALLRDPEIKTGKVSVASYLKFLDSVQFKSYGDEPLEVLAIVVEQNDKIPKLDKFLSSKTGWLNNVTDNIFNAIKKDYSQLCWVVNENDANLPWYFSKSDGSFAKNGQILFWYGLNIDEASKLIKEFDSSSIGSSLSSSKESGVFTSAQQKRGFHHSTVRRNTNPNPPLSEGKQTERKKVALIGARGYTGQNLIKLIDNHPYLDISYVSSRELEGQKLQGYNKDNIVYSNLQIEDIKRLEENNEVDVWVMALPNGVCKPFVDTIDLVQNPNSKIVDLSADYRFDTTGEWTYGLPELNDRKTIAQAKKISNPGCYATAAQVAIAPLKEYISGTPSIFGVSGYSGAGTKPSPKNDVNLLSNNLIPYSLTDHVHEKEISSQLGLQVAFTPHVAQWFQGITHTINIPIKKGSLTSREIRNIYQDRYQGEKLITISGEAPLVKDISGKHGVVVGGFAVNSNEDRVVIVATIDNLLKGAATQCLQNINLSQEFGEYDGIPTESLIRG
Protein: FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Q91ZT5)
Organism: Mus musculus (Mouse)
Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates MAPK8 (By similarity). Plays a role in regulating the actin cytoskeleton and cell shape. Promotes the formation of lamellipodia.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). {ECO:0000250}.
Interaction partners:
- GPI ethanolamine phosphate transferase 1
- Myotubularin-related protein 13
- Cell division control protein 42 homolog
- 1-phosphatidylinositol 3-phosphate 5-kinase
- SH3 domain and tetratricopeptide repeat-containing protein 2
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
Sequence:
MEESNPAPTSCTSKGKHSKVSDLISHFEGGSVLSSYIDLQKDSTMNLNIPQTLGQPGLTSSPPRKFLPQHSPQKQENDPDQTQGQHGCLANGVVAAQNQMECEDEKETTLSPEMAIQTAAASPDTHVLNGERNETITDSASSIANSHDENASDSSCRTPGTDLGLPSKEGEPGMDAELQERENGVNTMGLDTLDQHHEVKETNEQKLHKIATELLLTERAYVSRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAVELVKTMTERVPQFKSVTEEIQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDSPDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMKIVETHNEEYPHTFQISGKERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVSTAELGKRAPRWIRDNEVTMCMKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKDCYQIISGFTDSEEKKRRGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDDMPKSADLPHSFKLTQSKSVHSFAADNEELKQKWLKIILLAVTGETPDGPSEHLATLNNLPGPKKKSEC
Protein: poly(A)-specific ribonuclease (EC 3.1.13.4) (H0Y9C1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRA
Protein: Putative cell agglutination protein pfl8 (Adhesin pfl8) (Pombe flocculin 8) (Sim4-mal2-associated protein 5) (Q92344)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in agglutination during conjugation or other aspects of colony formation (By similarity). Induces flocculation when overexpressed.
Subcellular location: Secreted {ECO:0000269|PubMed:16823372}. Cell surface {ECO:0000305|PubMed:17870620}.
Interaction partners:
- Galactose-specific cell agglutination protein gsf2
- Putative cell agglutination protein pfl3
- MADS-box transcription factor pvg4
- Putative GPI-anchored protein pfl2
Sequence:
MNSYISLIFTLLFFTSAARSSSVSVETGSCVRYTTIYSSGSSEFTSTITPETPSSSSSTFVPISTHTSSATNTTSGQLSISSSSSTSSEYSSSSIPITTVSSSDSFIPSSSQTISASSSTTDNVIVSSSISSTVSSTPVSTIYSGTSGTTFVSSSTTYQVIPTQICDGVRGLEYAVYNYDLPSESTFCHPSNGYTEVSTFNKPAYFGSKDLKQSAPLFTGIFSSLDDIPTYSASDYLPAYPPNPEGMSSTSSSCKTIVYQFFFRVPATDNWSLFVKNVDDAFFGWFGDKAISGWSNVNYDAYAHWRIGAYGMGTFDLGYLEQDSFVPVRFVLANGAYIGGFDFAFNSSSTGPVRTTSYSYTSTCDKSFLPFGKGNGGLDEGTANV
Protein: Transcription factor PAR2 (Basic helix-loop-helix protein 166) (AtbHLH166) (bHLH 166) (Protein HELIX-LOOP-HELIX 2) (Protein PHYTOCHROME RAPIDLY REGULATED 2) (bHLH transcription factor bHLH166) (Q9LXR7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Atypical bHLH transcription factor that acts as negative regulator of a variety of shade avoidance syndrome (SAS) responses, including seedling elongation and photosynthetic pigment accumulation. Acts as direct transcriptional repressor of two auxin-responsive genes, SAUR15 and SAUR68. May function in integrating shade and hormone transcriptional networks in response to light and auxin changes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:17948056}.
Interaction partners:
- NEP-interacting protein 1
- AT4g26130/F20B18_240
- Auxin-responsive protein SAUR67
- Alcohol dehydrogenase class-3
Sequence:
MEKTLATSHTKRSSPPSPSSAVNTSSTGFNRRTRQRLSDATASVSETDVEDEDEDEEGVEEKIEALQTIVPGGTELGVDALFEETASYILALQCQINAIKVLTTFLERCEKKDMKFGG
Protein: Uncharacterized protein HI_0275 (P43975)
Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MIAYIFLALFTIAAVIFIVNSHYRWTYFFAITLFTFLFGGMLMVSSQWQRALNFSSVLFVVLMLFHRLKIHYYKQPLLISDFFLVVDWRNWETLIHYKGALFGVIGLLALLGYAIFGFNDVESLGVLGNSIGALLFIVSFSLMWHYSKNPSAVQVWLDSLPDDGRDVFLNLPMSCRGIFFKVPNFDGNSQNFIEKMTALSSDANNLSETKPDIVVTLMESTLNPHQFAFSQQSIPPLSMFEPQNDTVFASPLRVHTFAGATWKSEFAFLAGVPSTDFGALASGVFYSVVPHLQSGLVKNLKAQGYFCVALSPFTKGNYNAKSAYDHFGFDLMLQPQDLGYPAPISKNLWDISSEEMMKYTRMILEKQHPALENVDQPMFVYVLTMREHGPYELGMENTFNLQMPNLGAKSISALNDYTQRIVALNDAIEGINNYLHERKKPFVLGYFGDHQVAFDNAIPPKKGDYAQPDYVTQFVVRSNCASQFKQEQKFLDLAFAGGVLMNVAGLSAEDEFMKANMAMCKLSDGKLEDSSDIQLLNNYRHYLYQTLAIAR