wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein 563 (Q8TA94)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLDCIRMIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGHLSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKCKLCGKAFFWPSLLRMHERTHTGEKPYECKQCSKAFPFYSSYRRHERMHTGEKPYECKQCSKALPDSSSYIRHERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYECKQCGKTFHHLGSFQIHMKRHTGDRPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKAFVYPSVCQRHEKSHSGEKPYECKQCGKALSHSSSFRRHMVMHTGDGPNKCKVCGKAFVYPSVCQRHEKTHWRETI
Protein: VQ motif-containing protein 29 (AtVQ29) (Q9SZG3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as negative regulator of flowering transition.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9M9F0}.
Interaction partners:
- VQ motif-containing protein 8, chloroplastic
- VQ motif-containing protein 17
- VQ motif-containing protein 18
- VQ motif-containing protein 9
- Calmodulin-binding protein 25
- VQ motif-containing protein 22
- Sigma factor binding protein 2, chloroplastic
- Protein HAIKU1
- VQ motif-containing protein 20
- VQ motif-containing protein 10
Sequence:
MEATSQQFMSQSYLNAQETTTRATKNYLTSLHSTRKQPSKPLKRPAISSPLNPMHPHVYRVEPVNFKVLVQRLTGAPEHETVQAKPLKTSDDAAKQSSSSFAFDPSSSWGDFSFQNPANISRW
Protein: Antitoxin FitA (Trafficking protein A) (Q5F881)
Organism: Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Plays a role in the speed with which bacteria traverse human epithelial cells; disruption of the locus increases the speed of trafficking about 2-4-fold. Binds to its own promoter, binding affinity of the FitAB complex is 20-30-fold higher than FitA alone. No nuclease activity was observed for the FitAB complex, perhaps because FitA (the antitoxin) prevents metal binding and thus catalysis by FitB.
Interaction partners:
- Toxin FitB
Sequence:
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL
Protein: GH19585p (Q7JWR4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Proteasome assembly chaperone 2
- AT13539p
- Proteasome assembly chaperone 1
- GEO05038p1
Sequence:
MDSVPANVVPAKESGGFTSHCVHLAAGPSQFTVRALKMQGSTMLIINPKGLEVFEELAVAMPSRNPASSQSLSSTILGGHGQTDSSVLAAKLSKRYCRQFYVSLNLKLDRLMGPLFEKTLVTYMQDHLEHFA
Protein: Chaperonin GroEL 1 (EC 5.6.1.7) (60 kDa chaperonin 1) (Chaperonin-60 1) (Cpn60 1) (P31681)
Organism: Chlamydia pneumoniae (Chlamydophila pneumoniae)
Function: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00600}.
Interaction partners:
- Co-chaperonin GroES
- Chaperone protein DnaK
- Protein GrpE
- Chaperonin GroEL 2
- Major outer membrane porin
- Large cysteine-rich periplasmic protein OmcB
- Histone H1-like protein HC1
- Heat-inducible transcription repressor HrcA
- Elongation factor Tu
- Chaperone protein DnaJ
Sequence:
MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY
Protein: Recombination signal binding protein for immunoglobulin kappa J region (A0A8I6AN87)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTGLFYPQLLRKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSQVPTNESNTNSEGNYTNASTNSTSVTSSTATVVS
Protein: Histone H2A type 1-J (Histone H2A/e) (Q99878)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H2A type 1
- Histone H4
- Histone H2B type 1-J
- Histone H2B type 1-K
- Histone H2A type 1-B/E
- Histone H3.2
- Histone H2A type 1-C
- Histone H2B type 1-M
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Sex comb on midleg-like protein 2
Sequence:
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKTK
Protein: T-box transcription factor TBX2b (T-box protein 2b) (Q7ZTU9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor which acts as a transcriptional repressor (By similarity). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity). Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13207}.
Interaction partners:
- NK2 homeobox 5.
- Bone morphogenetic protein 4.
- Natriuretic peptide A
- Hyaluronan synthase 2
- Insulin gene enhancer protein isl-1
- GATA-binding protein 4.
- Forkhead box protein N4
- Heart- and neural crest derivatives-expressed protein 2
- Versican core protein
- Notch receptor 1b.
Sequence:
MRDPVFTGTAMAYHPFHAHRPTDFPMSAFLAAAQPSFFPALTLPPGALTKPIPDHTLAGAAEAGLHPALSHHHQAAHLRSLKSLEPEEEVEDDPKVTLEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRINGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRMYEDQCKVDRDGADSDASSSEPTTGRDAGHSPGPVSSPLRFNRGSRDDKTCTDSEHEMDHQNDRCGGSSSPAPEPSSPFRSRSEDWGREKPIAEKKDDYPDSRKTSDSIFSIRNLEKDKLESRSRKDTDSSKKDTENSGISGSKDSFSPLMVQTESPSHFGAGHLQSLALSGLHSQQFFNPLNTGQPLLFHPGQFAMAPGAFSAMGMGHLLASVSGAGGLENGSLSAQGTGSTPSPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPASSSTASSLSRNPFLSSSTRPRLRFNPYQLPVSIPQSTNLLTTGLPSGLNPSSESSKCGSREASPVPDHKSGASQRNGSPKTTMKESINELQNIQRLVSGLESQRETSSPRDSPK
Protein: Auxin response factor 7 (Auxin-responsive protein IAA21/IAA23/IAA25) (Protein BIPOSTO) (Protein MASSUGU 1) (Protein NON-PHOTOTROPIC HYPOCOTYL 4) (Protein TRANSPORT INHIBITOR RESPONSE 5) (P93022)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Acts as a transcriptional activator of several tropic stimulus-induced (TSI) genes, including SAUR50. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Required for differential growth responses of aerial tissues. Involved in ethylene responses. Regulates lateral root formation through direct regulation of LBD16 and/or LBD29. Functionally redundant with ARF19. Mediates embryo axis formation and vascular tissues differentiation. Functionally redundant with ARF5. Involved in cellular dedifferentiation during callus formation on callus-inducing medium (CIM) and in an ATXR2-dependent manner.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00326, ECO:0000269|PubMed:29184030}.
Interaction partners:
- Auxin-responsive protein IAA14
- Transcription factor MYB77
- Auxin-responsive protein IAA17
- Cyclin-dependent kinase E-1
- Auxin transporter protein 1
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 6
- Auxin-responsive protein IAA8
Sequence:
MKAPSSNGVSPNPVEGERRNINSELWHACAGPLISLPPAGSLVVYFPQGHSEQVAASMQKQTDFIPSYPNLPSKLICMLHNVTLNADPETDEVYAQMTLQPVNKYDRDALLASDMGLKLNRQPNEFFCKTLTASDTSTHGGFSVPRRAAEKIFPALDFSMQPPCQELVAKDIHDNTWTFRHIYRGQPKRHLLTTGWSVFVSTKRLFAGDSVLFIRDGKAQLLLGIRRANRQQPALSSSVISSDSMHIGVLAAAAHANANNSPFTIFYNPRAAPAEFVVPLAKYTKAMYAQVSLGMRFRMIFETEECGVRRYMGTVTGISDLDPVRWKNSQWRNLQIGWDESAAGDRPSRVSVWDIEPVLTPFYICPPPFFRPRFSGQPGMPDDETDMESALKRAMPWLDNSLEMKDPSSTIFPGLSLVQWMNMQQQNGQLPSAAAQPGFFPSMLSPTAALHNNLGGTDDPSKLLSFQTPHGGISSSNLQFNKQNQQAPMSQLPQPPTTLSQQQQLQQLLHSSLNHQQQQSQSQQQQQQQQLLQQQQQLQSQQHSNNNQSQSQQQQQLLQQQQQQQLQQQHQQPLQQQTQQQQLRTQPLQSHSHPQPQQLQQHKLQQLQVPQNQLYNGQQAAQQHQSQQASTHHLQPQLVSGSMASSVITPPSSSLNQSFQQQQQQSKQLQQAHHHLGASTSQSSVIETSKSSSNLMSAPPQETQFSRQVEQQQPPGLNGQNQQTLLQQKAHQAQAQQIFQQSLLEQPHIQFQLLQRLQQQQQQQFLSPQSQLPHHQLQSQQLQQLPTLSQGHQFPSSCTNNGLSTLQPPQMLVSRPQEKQNPPVGGGVKAYSGITDGGDAPSSSTSPSTNNCQISSSGFLNRSQSGPAILIPDAAIDMSGNLVQDLYSKSDMRLKQELVGQQKSKASLTDHQLEASASGTSYGLDGGENNRQQNFLAPTFGLDGDSRNSLLGGANVDNGFVPDTLLSRGYDSQKDLQNMLSNYGGVTNDIGTEMSTSAVRTQSFGVPNVPAISNDLAVNDAGVLGGGLWPAQTQRMRTYTKVQKRGSVGRSIDVNRYRGYDELRHDLARMFGIEGQLEDPQTSDWKLVYVDHENDILLVGDDPWEEFVNCVQSIKILSSAEVQQMSLDGNFAGVPVTNQACSGGDSGNAWRGHYDDNSATSFNR
Protein: Nuclear protein localization protein 4 homolog (Protein NPL4) (P60670)
Organism: Mus musculus (Mouse)
Function: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ES54}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9ES54}. Nucleus {ECO:0000250|UniProtKB:Q9ES54}. Note=Associated with the endoplasmic reticulum and nuclear. {ECO:0000250|UniProtKB:Q9ES54}.
Interaction partners:
- Ubiquitin recognition factor in ER-associated degradation protein 1
- Transitional endoplasmic reticulum ATPase
- UBX domain-containing protein 7
- FAS-associated factor 2
- FAS-associated factor 1
- Fanconi anemia group M protein homolog
- Phospholipase A-2-activating protein
- NSFL1 cofactor p47
- Deubiquitinating protein VCPIP1
- Tether containing UBX domain for GLUT4
Sequence:
MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSSKSLHLLKIKHGDLLFLFPSSLAGPSSEMETSTSVGLKAFGAPNVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLHEFGAVGGSARAATSAMWACQHCTFMNQPGTGHCEMCSLPRT
Protein: Cell growth regulator with EF hand domain protein 1 (Cell growth regulatory gene 11 protein) (Hydrophobestin) (Q99674)
Organism: Homo sapiens (Human)
Function: Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Cell growth regulator with RING finger domain protein 1
Sequence:
MLPLTMTVLILLLLPTGQAAPKDGVTRPDSEVQHQLLPNPFQPGQEQLGLLQSYLKGLGRTEVQLEHLSREQVLLYLFALHDYDQSGQLDGLELLSMLTAALAPGAANSPTTNPVILIVDKVLETQDLNGDGLMTPAELINFPGVALRHVEPGEPLAPSPQEPQAVGRQSLLAKSPLRQETQEAPGPREEAKGQVEARRESLDPVQEPGGQAEADGDVPGPRGEAEGQAEAKGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVHIVQVENDEI
Protein: Proliferating cell nuclear antigen (PCNA) (Cyclin) (P17918)
Organism: Mus musculus (Mouse)
Function: Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:24115439}. Note=Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (By similarity). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. {ECO:0000250|UniProtKB:P12004}.
Interaction partners:
- Replication factor C subunit 4
- Flap endonuclease 1
- DNA ligase 1
- Replication factor C subunit 3
- Replication factor C subunit 2
- DNA mismatch repair protein Msh6
- DNA polymerase delta catalytic subunit
- DNA polymerase eta
- DNA polymerase delta subunit 2
- Replication factor C subunit 5
Sequence:
MFEARLIQGSILKKVLEALKDLINEACWDVSSGGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVIKMPSGEFARICRDLSHIGDAVVISCAKNGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVHLTFALRYLNFFTKATPLSPTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEAS
Protein: Nebulin (Q62411)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
PADMLSVTAAKDAQANITNTNYKRLIHKYILLPDAMNIELTRNMNHIQSDNEYKQDYREWYRGLGWSPAGSLEVEKAKKATEYASDQKYRQHPSTFQFKKLTDSMDMVLAKQNAHTMNKHLYTIDWNKDKTKIHVMPDTPDILQAKQNQTLYSQKSYRLGWEEALKKGYDLPVDAISVQLAKTSRDIASDFKYKQGYRKQLGHHIGFLSVQDDPKLVLSMNVAKMQSDREYKKDFEKWKTKYTSPVDMLGVVLAKKCQALVSDADYRNYLHQWTCLPDQNDVIQAKKVYELQSENMYKSDLEWLRGIGWSPLGSLEAEKNKRASEIISEKKYRQPPDRNKFTSIPDAMDIVLAKTNAKNRSDRLYREAWDKDKTQIHIMPDTPDIILAKANLINTSDKLYKMGYEELKKKGYDLPVDAIPIKAAKASREIASEYKYKEGFRKQLGHHIGARNIKDDPKMMWSMHVAKIQSDREYKKDFEKWKTKYSSPVDMLGVVLAKKCQTLVSDADYRNYLHQWTCLPDQNDVIHARQAYDLQSDNVYKADLQWLKGIGWIPSGSLEDEKNKRATQILSDHVYRQHPNKFKFSSLMDSMPMVLAKNNAITMNHHLYTEAWNKDKTTVHIMPDTPEVILAKQNKVNYSEKLYKLGLEEAKRKGYDMRLDAIPIKTAKASRDIASDFKYKEGYRKQLGHHIGARGIHDDPKMMWSMHVAKIQSDREYKKDFEKWKTKYSSPVDMLGVVLAKKCQTLVSDADYRNYLHQWTCLPDQNDVIHARQAYDLQSDNMYKSDLQWMRGIGWVPIGSLDVEKCKRATEILSDKIYRQPPDKFKFTSVTDSLEQVLAKNNAITMNKRLYTEAWDKDKTQIHIMPDTPEIMLARMNKVNYSESLYKLANEEAKKKGYDLRSDAIPIVAAKASRDIASDYKYKDGYRKQLGHHIGARNIKDDPKMMWSMHVAKIQSDREYKKDFEKWKTKYSSPVDMLGVVLAKKCQILVSDIDYKHPLHEWTCLPDQNDVIHARQAYDLQSDNVYKSDLQWMRGIGWVPIGSLDVVKCKRAAEILSDNIYRQPPNKFKFTSVTDSLEQVLAKSNALNMNKRLYTEAWDKDKIQIHVMPDTPEIMLARQNRINYSESLYKLANEEAKKKGYDLRVDAIPIVAAKASRDIASDYKYKVGYRKQLGHHIGARNIEDDPKMMWSMHVAKIQSDREYKKDFEKWKTKYSSPVDMLGVVLAKKCQTLVSDVDYRNYLHQWTCLPDQNDVIHARQAYDLQSDNVYKSDLQWMRGIGWVPIGSLDVVKCKRAAEILSDNIYRQPPNKFKFTSVTDSLEQVLAKSNALNMNKRLYTEAWDKDKTQIHIMPDTPEIM
Protein: 5-demethoxyubiquinone hydroxylase, mitochondrial (DMQ hydroxylase) (EC 1.14.99.60) (Catabolite repression protein 5) (NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase) (EC 1.14.13.253) (Ubiquinone biosynthesis monooxygenase COQ7) (P41735)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the hydroxylation of 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing COQ3 and COQ4 polypeptides.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:24406904, ECO:0000269|PubMed:9452453}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:24406904}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:24406904}.
Interaction partners:
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Ubiquinone biosynthesis protein COQ4, mitochondrial
- Ubiquinone biosynthesis protein COQ9
- Atypical kinase COQ8, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Hexaprenyl pyrophosphate synthase, mitochondrial
- MIOREX complex component 2
- mRNA-binding protein PUF3
Sequence:
MLSRVSVFKPASRGFSVLSSLKITEHTSAKHTEKPEHAPKCQNLSDAQAAFLDRVIRVDQAGELGADYIYAGQYFVLAHRYPHLKPVLKHIWDQEIHHHNTFNNLQLKRRVRPSLLTPLWKAGAFAMGAGTALISPEAAMACTEAVETVIGGHYNGQLRNLANQFNLERTDGTKGPSEEIKSLTSTIQQFRDDELEHLDTAIKHDSYMAVPYTVITEGIKTICRVAIWSAERI
Protein: Aquaporin-4 (A0A2R8Q5A8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004415}. Cell projection {ECO:0000256|ARBA:ARBA00004316}. Endosome membrane {ECO:0000256|ARBA:ARBA00004608}.
Interaction partners:
Sequence:
MRKAFSRVSVQNKSCGVIRRCVSSCSCNNSIMAAFKGVWTQEFWRAVSGEFLAMIIFVLLSLGSTINWGAKQENPPPADLVLISLCFGLSIATLVQCFGHISGAHINPAVTVAMVATRKLSLAKGVFYLLAQCLGAVVGAAILYGVTPASVRGGMGVTSVNEEISAGHAIVIELIITFELVFTVFATCDPKRNDLKGSAALAIGLSVCIGHLFAIPYTGASMNPARSFGPAVIMVKWQDHWVYWVGPLIGGILAAAVYEYLFCPDPDLKRRYADVLSKSPFQMEPYRVVDTDSYPSDQAQLMAKQAALRVLDLEKKERESTGEVLSSV
Protein: Small ribosomal subunit protein mS40 (28S ribosomal protein S18-2, mitochondrial) (28S ribosomal protein S18b, mitochondrial) (Q9VIN9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Small ribosomal subunit protein mS33
- GH07821p
- GEO10172p1
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein mL66
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein uS7m
- FI07234p
- Small ribosomal subunit protein uS9m
Sequence:
MLPIARGIYIGLVNITRNSRGALHTASALRCKAETSTEENNAAATEGEGEDNASGSAPDPKDRSKPIPVETSIRYLKSAAYKQTYGEDFVWTQYRRNHKGMYAPRKTRKTCIRQNRISTGNPCPICRDEYLVLDYRNTELLEQFISPHSGDVLSYSKTGLCQKSHLRLMVAVQQARDSGYLTYDVPFREYDYSEYYGQEQKQKA
Protein: Lipoprotein, putative (O06384)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MIRLVRHSIALVAAGLAAALSGCDSHNSGSLGADPRQVTVFGSGQVQGVPDTLIADVGIQVTAADVTSAMNQTNDRQQAVIDALVGAGLDRKDIRTTRVTVAPQYSNPEPAGTATITGYRADNDIEVKIHPTDAASRLLALVVSTGGDATRISSVSYSIGDDSQLVKDARARAFQDAKNRADQYAQLSGLRLGKVISISEASGAAPTHEAPAPPRGLSAVPLEPGQQTVGFSVTVVWELT
Protein: Interleukin-36 alpha (FIL1 epsilon) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 6) (IL-1F6) (Interleukin-1 homolog 1) (IL-1H1) (Q9JLA2)
Organism: Mus musculus (Mouse)
Function: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of pro-inflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role in pro-inflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T-cell proliferation. Induces NF-kappa B activation in macrophages.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UHA7}. Secreted {ECO:0000250|UniProtKB:Q9UHA7}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:Q9UHA7}.
Interaction partners:
- Interleukin-1 receptor-like 2
- Interleukin-1 receptor accessory protein
- Interleukin-36 receptor antagonist protein
- Interleukin-1 receptor type 1
- Interleukin-36 beta
- Interleukin-6
- Tumor necrosis factor
- Interleukin-1 beta
Sequence:
MNKEKELRAASPSLRHVQDLSSRVWILQNNILTAVPRKEQTVPVTITLLPCQYLDTLETNRGDPTYMGVQRPMSCLFCTKDGEQPVLQLGEGNIMEMYNKKEPVKASLFYHKKSGTTSTFESAAFPGWFIAVCSKGSCPLILTQELGEIFITDFEMIVVH
Protein: Clc-like protein (Q9N419)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Innexin-19
- G_PROTEIN_RECEP_F1_2 domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- Serpentine receptor class r-10
- NAD
- Mitogen-activated protein kinase kinase kinase nsy-1
- Voltage-dependent calcium channel unc-36
- Calcium/calmodulin-dependent protein kinase type II
Sequence:
MSSGADLGRKGSLFLSLLFSFIGAGLSIAAILTPSWQIVNLREYGSIHEHGLWLDCTRHSRDGNHILQRYATVTEPLHCVYKFDYDKYSGTFELEDDNSPVGEVNRHKFYGWHTSTMILLGFALLTTGLSTFIGACACCHSSLALFFTIITLLTTLLSAIAEGIFFFYSHRADNRFIKGIVGTYEQRVGTAFFLQMAAAFCHLISFLIAMLFTYFSFASSKDSDGFSIQRSSRTNVTNIGRSIEFDAPLMYPPQTPISGFRAASYMDDKPVIAESMPELGHRGAYPSNDFLSSRIRRKSETCV
Protein: IP01524p (Ods-site homeobox) (Q9VX20)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit alpha
- LD09786p
- Uncharacterized protein
Sequence:
MDQLIQQLQQAAAARGQVQHPHGSSALQLYAAAAAVNMQVSGWSSVLNLSMDAPNPEISPNSVTNSSSVYMIRQMALIQQARVAAAAVAMQQQQQQQRDLNRELGMDPHSEQRIKLDSVSPTHNIHAGSSRGIKQDPLSDEGADSNLGQNDCTESSKKRRGRTNFNSWQLRELERVFQGSHYPDIFMREALATKLDLMEGRIAVWFQNRRAKWRKQEHTKKGPGRPAHNAHPQSCSGDPIPLSELRARELAQRSKRMKKAIDRQAKKLQDKGLEVDYARLEAEYLAAHQENGVDENNWLDDDGYDDLHIDVVGVEPEYVTGDSLDHSFCSSRTYQTKSTSSELDSNDMGLQGRVETPPPPQPPMQNKTLYNSPFSIESLLGS