wanglab/gogpt-training-data huggingface dataset:
Protein: Negative elongation factor C/D (NELF-C/D) (TH1-like protein) (Q8IXH7)
Organism: Homo sapiens (Human)
Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Negative elongation factor A
- Negative elongation factor E
- Negative elongation factor B
- Transcription elongation factor SPT5
- Transcription elongation factor SPT4
- DNA-directed RNA polymerase II subunit RPB1
- Nuclear cap-binding protein subunit 1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB3
- Propionyl-CoA carboxylase beta chain, mitochondrial
Sequence:
MAGAVPGAIMDEDYYGSAAEWGDEADGGQQEDDSGEGEDDAEVQQECLHKFSTRDYIMEPSIFNTLKRYFQAGGSPENVIQLLSENYTAVAQTVNLLAEWLIQTGVEPVQVQETVENHLKSLLIKHFDPRKADSIFTEEGETPAWLEQMIAHTTWRDLFYKLAEAHPDCLMLNFTVKLISDAGYQGEITSVSTACQQLEVFSRVLRTSLATILDGGEENLEKNLPEFAKMVCHGEHTYLFAQAMMSVLAQEEQGGSAVRRIAQEVQRFAQEKGHDASQITLALGTAASYPRACQALGAMLSKGALNPADITVLFKMFTSMDPPPVELIRVPAFLDLFMQSLFKPGARINQDHKHKYIHILAYAASVVETWKKNKRVSINKDELKSTSKAVETVHNLCCNENKGASELVAELSTLYQCIRFPVVAMGVLKWVDWTVSEPRYFQLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVKLFETEHSQLDVMEQLELKKTLLDRMVHLLSRGYVLPVVSYIRKCLEKLDTDISLIRYFVTEVLDVIAPPYTSDFVQLFLPILENDSIAGTIKTEGEHDPVTEFIAHCKSNFIMVN
Protein: Anon1A3 (O16040)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
ATEKYAPEEAKEDVAEAKEEDASPAGVQDQPDGVENLPSVAEAKQNHVDEVKPISEEPGNSSEEVPKAEEPLKSSGETSENGAATETAAAPKEPASVMDVDEDETLVENTPSANKEKALDDEKEPEQKSEEHAAAVLESKEQNEPAKEPTPEPMEVDGSSKGSSDTAQVDTPAIENVSAAPETEAAAKTTESSNDVVEVATEGKETVLEVPAAEPKEAESTVESAEELTETSTVVTEPKEAASSEEEPSKVVDSAEPKEAESNTDESATPVPIDVSTAPASNDVSKPLEIDTTLVKTADSPAKEPQEICEVKKAEINVNGEPKIVNSSAEVGENAAPKVCN
Protein: LOB domain-containing protein CRL1 (Protein ADVENTITIOUS ROOTLESS 1) (OsARL1) (Protein CROWN ROOTLESS 1) (Q5UG13)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Acts as positive regulator of adventitious (crown) root formation by promoting its initiation. Acts as positive regulator of lateral root formation. Regulated by the auxin response factor and transcriptional activator ARF23/ARF1. Involved in auxin-mediated cell dedifferentiation, and may promote the initial cell division in the pericycle cells adjacent to the peripheral vascular cylinder at the base of the stem. May act upstream of the gene regulatory network controlling adventitious root (crown) development.
Subcellular location: Nucleus {ECO:0000269|PubMed:15960615}.
Interaction partners:
- Os03g0207900 protein
- Os06g0255200 protein
- Nuclear pore complex protein
Sequence:
MTGFGSPCGACKFLRRKCVRGCVFAPYFCHEQGAAHFAAIHKVFGASNVSKLLAHLPLADRPEAAVTISYEAQARLRDPIYGCVAHIFALQQQVMTLQAQLASLKAAAAQGIHHQDVGATTKGGYMSAAATAADDQLGYGGYNQWCGSNGGGAPAASQPGAYSSNGGAGHGHDSITALLAAGSDYMQHSLYHAFEHSEGAGAVDDGHAAAAAFEAAAESSSCGMAASFAADESVWRSSSSGYQDCEDLQSVAYAYLNRS
Protein: Cyclin-dependent kinase 2 homolog (Cell division control protein 2 homolog) (cdc2-related kinase 2) (Q8I1T4)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- CPSF, subunit A, putative
- Transcription elongation factor SPT5, putative
- Uncharacterized protein
Sequence:
MNVKDVDTLLDIFRGGPGVHTCSGIENYFLENNTLDVDIKKEFIKRLENPTFLSKFCMLKRKFVYNFFLVKKEIVKKRLWTYIENIIDKLNDDDIIKVHKYLEKESGNVIHTFLNNLYLYKDMENKRRRRKNIKRKKKEKKKRNNHDIYNNCNINSNKLDCNLPYNLNLENIFWKQINLKNYKKKYFYHINKNINSLWKVYLSYNLLNINKCERKDLIKNILHTLLKKEYEQLSCFEWDSKVVLYKLLKNQDLKKCSLENYTEDDVTSNPSNDFDNTVDIDLNMKENVQNKDKVHVGDKIGSIPEGDNICLQTDDQTYNHNNNNIMLKKKKKSSENHILINSNNVLLNYNKNSELLDDCFKLCNNNNNNVHIYDKSNVSYTNLNDLKNGYYKDTDIIYDLLLKSIKGEIKLKVKNFVKVHQVGQGAYGDVWMAEDIINNQRVALKKLKLNEEKDGFAKTYIREISILNSLKHENIVELIGVVHSILPVNFNNQNMINQSPQNSHPIHINHNNIFHNKFFDQNNYKDFLITEKNYFGNKKNRRTLNEDMLSVVDISSNEDMLSVVDISSNEDMLSVVDISSNEDMLSVVDISSNEDMLSVVDISSNVDISPNQDISPNQDISPNDCYTLNNLLNHNQVDPSTSLSISSYEDTTSSNSSHSNCSSSSVSSFMSYDKNKEKKSCIWMVFEYVPFDLSGYSELLREERNEKERYKYANLFSIGEIKNIFIQLLKALDYCHKNNIIHRDIKIANLLIDNNGILKLADFGLARFHSDINASNMTNRVITLWYRPPELLLGSENYMASVDMWSCGCVLAELLTSNPLFSAENETDILKIIVNKLGFPNERDIKYLRNLPCWNLLKLNPIHPNNIHHNINHNKKIETETSIRNIPGVGDLGLDLIKKFLKWNPYERITASDALNHPWFKTQPLSEKIHQRNNIKAAHSFMTKNYKKRDLPKNTYSKINENFRFINVGNYRKAYLRSKYNDHLLYLNSLSSKRDVLKEQPLQQIDKKTEEDKETKTETTNMEQKDKKHKELVNIKKEDEPGETKKCKVESVTDYSDRENLKPTFDNDIKKNEHKLNSNKSDIDKTRKSATISRDGSLRRNERKTIAVIKYYDHKMKEYNHNRSPSHAKKYNNEKREKEKKIEGIDNRRESNNYFRRSREGIDDRRRYSTICKTGYNNADVYRDRISHRSREREWYKKPYGRRSRDRDRERDRDRERDRERDRERDRDRERDRERERDRDRDRDRERDRNRERDRDRERDRERDRNRERDRDRDRDRDRDRDRDRDRDRDRDRDRDRDREKERKRDKDKDKENDKSKDADQKKHKLDTEELRVEKKKKI
Protein: C-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR) (Q6UVW9)
Organism: Homo sapiens (Human)
Function: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855}; Single-pass type II membrane protein {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855}.
Interaction partners:
- Killer cell lectin-like receptor subfamily F member 2
- Killer cell lectin-like receptor subfamily B member 1
- Killer cell lectin-like receptor subfamily F member 1
Sequence:
MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGWFEIIGNGSFAFLSADGVHSSRGFIDIKWICSKPKYFL
Protein: Monothiol glutaredoxin-4 (P32642)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (Probable).
Interaction partners:
- Iron-regulated transcriptional activator AFT1
- BolA-like protein 2
- Fe-S cluster assembly protein DRE2
- EKC/KEOPS complex subunit BUD32
- BolA-like protein 1
- BolA-like protein 3
- Monothiol glutaredoxin-3
- S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
- Iron-sulfur assembly protein 1
- Protein CCC1
Sequence:
MTVVEIKSQDQFTQLTTTNAANKLIVLYFKAQWADPCKTMSQVLEAVSEKVRQEDVRFLSIDADEHPEISDLFEIAAVPYFVFIQNGTIVKEISAADPKEFVKSLEILSNASASLANNAKGPKSTSDEESSGSSDDEEDETEEEINARLVKLVQAAPVMLFMKGSPSEPKCGFSRQLVGILREHQIRFGFFDILRDENVRQSLKKFSDWPTFPQLYINGEFQGGLDIIKESIEEDPEYFQHALQ
Protein: RE32485p (Q8SYV5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVKDILQRCKPIPLYTVLVLSICYFVLQLILSHLTHGLTLLMASHHMLCNIFALGGCIITIKYSKQAPEARNPSPALTKINGSGVAISLADTDAQTRAKRECREQKLRNTFGWARIDILTMLIVFIILASLSFSLVVEALQTLVHIDHQDTMHLPIPVMMLGFIGLILNGLTYLLIGGYTLHQGSFLHLTPGGNVVLERPMSSNLDLSLTPMQRHLSNSRNDRQLREELETEVGSVYFATKRQGAVEMLRDVSSTIFVIVCAAIVYVAEDEQHTAKFIDPVLSIFSCVLLVTLSYPYMKESCLILLQTIPGSIDLEIFERTLVTKFPEIISYHDLHIWQLAAHRYVATIHIQFQNPKLYLKIIEQVRSYFHDQGIGAVTIQPEFYPSTNKNASASLECLMQCQAVECIEKVCCRDSRTDLREVCDAPSGRKSSSPVKCAGNSHEHSRAKSKSCAELSAVVVEKPEELSAGQLLKGQDQQVAKSMPKLEETCVDATKEDTAELSGSPPGPTSSD
Protein: Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein) (P28229)
Organism: Mus musculus (Mouse)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Interaction partners:
- Gap junction alpha-5 protein
- Gap junction alpha-1 protein
- Gap junction delta-3 protein
- Gap junction alpha-3 protein
- Gap junction delta-2 protein
- Gap junction alpha-4 protein
- Tight junction protein 1
- Gap junction beta-6 protein
- Gap junction beta-2 protein
- Gap junction alpha-8 protein
Sequence:
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKTSVWI
Protein: Methyltransferase 22, Kin17 lysine (Methyltransferase-like protein 22) (Zgc:194177 protein) (B3DIQ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Kin17 DNA and RNA-binding protein.
- protein-histidine N-methyltransferase
- Electron transfer flavoprotein beta subunit lysine methyltransferase
- Calmodulin-lysine N-methyltransferase.
- ATP synthase subunit C lysine N-methyltransferase
- Dual specificity phosphatase 28
- Si:dkey-69o16.5.
- EEF1A lysine methyltransferase 1
- Protein N-lysine methyltransferase METTL21A
- Zinc finger CCCH domain-containing protein 15
Sequence:
MDQVTFRSDTVLSDVHLLLPNTRHLMKRLNGVGQPVFTSKFRILRDIDGKDSSDDLPVRESSDASDVPRDEDGDLDVVRRPRDTTSDRDAVCPIILSQSAATSSDQDEDSDEEEESARDIIIIEHTMATPLEDVGKQIWRGAFLLADFILAQSSMFKGATVLELGAGTGLTSIVMAMVAKTVYCTDVGEDLLNMCQRNVTVNKQHFEPQESEIMVRQLDWMADDFCTDADLEFSWTDIEVADLHDNTTFVIAADVCYDDDLTDALFRTIYRLSSNMRKPSTAYISIEKRLNFTLQHMDVSCEAYDHFRHCLDQLQQMKDGKMNFKVELVKISFPQFFQYERVEQLELWKVTAERLNK
Protein: Krt78 protein (Q0VDM9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSLSPCRAQRGFSAHSACSAFSGARGRTGFSSRSLSSSRRCRGSSCGRAWGAETRQGIRFGQGKGGPGFSQCPPGGIQAVTVDQSLLTPLKIEVDPQFQVVKTQETREIRSLNNQFASFIDKVRFLEQQNKVLETKWELLQQLQGNRSPQGLECIFETCLARLRQQLEELQRERRALDSELKTYQDQEDEYKSKYDQEAYKHASVQNDFVVLKKDVDEVFQSKMDLEGNLESLKEHVCFLTRLYEEELGQLKTQADDMSVVLSMDNNRCLDFSDIIAEVRARYEEITRTSKAEAEAVFQTKYQELQESAQLQGNSMKEAQVQISQLRQAIHRLQSQIGSLRKQNDSLQSAIADAEQQGEMAVRDAQAKLDELEAALRTAKQDMAQMLRDYQELMGTKLSLDVEIAMYRRLLESEECRISTEHTSQVTVSITEGSIVPGRTCGGQVVVPGRIGTGQVVMPGRECGGHVVMPGRGSGGQVTIPGRGSGGQVTVP
Protein: UL16-binding protein 2 (ALCAN-alpha) (NKG2D ligand 2) (N2DL-2) (NKG2DL2) (Retinoic acid early transcript 1H) (Q9BZM5)
Organism: Homo sapiens (Human)
Function: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12782710}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Secreted {ECO:0000269|PubMed:11444831}. Note=In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi. {ECO:0000269|PubMed:12782710}.
Interaction partners:
- NKG2-D type II integral membrane protein
- MHC class I polypeptide-related sequence B
- UL16-binding protein 3
- UL16-binding protein 1
- Hematopoietic cell signal transducer
- MHC class I polypeptide-related sequence A
- Natural killer cells antigen CD94
- CD226 antigen
- Leukocyte immunoglobulin-like receptor subfamily B member 1
- Natural cytotoxicity triggering receptor 3
Sequence:
MAAAAATKILLCLPLLLLLSGWSRAGRADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYDCGNKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTPKEPLTLQARMSCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTTVHPGARKMKEKWENDKVVAMSFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPCFILPGI
Protein: Ankyrin repeat and SAM domain-containing protein 1A (Odin) (P59672)
Organism: Mus musculus (Mouse)
Function: Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction.
Subcellular location: Cytoplasm {ECO:0000250}. Cell projection {ECO:0000269|PubMed:17875921}. Note=Cytoplasmic before and after growth factor treatment. {ECO:0000250}.
Interaction partners:
Sequence:
MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGSGSGGGSGGGGLGSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHRDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIQQGPSHTRVNEQNALEIRELKKYGPFDPYINAKNNDNETALHCAAQYGHTEVVKALLEELTDPTMRNNKFETPLDLAALYGRLEVVKLLLGAHPNLLSCSTRKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGIDVNIKDNRGLTALDTVRDLPSQKSQQIAALIEDHMTGKRSVKEVDRTSTAQLPLLSNTDAIAPMSQGSMEKTVTELILHFDTHADEEGPYEALYNAVSCHSLDSTASGRSSDRDSMNKEAEATGTRAAGVRPRERPPPPAKPPPDEEEEERVDKKYFPLAASEGLAVRPRIQSSAPQEEEEHPYELLLTAETKKLGTTDGRTEDHRQSGSGRSQDSVEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLLTAPSQSHPESSQQDACHEASMQLEEPGVQGTEPPQPGVPDQSKRVGLPAGLTALASRTYLDALTHTVPLRPAGAEEEDQSGPRSRAPPTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDEIEKIMSSIGEGIDFSQEQQKISGSRTLEQSVGEWLESIGLQQYESKLLLNGFDDVRFLGSNVMEEQDLREIGISDPQHRRKLLQAARSLPKVKALGYDGVSPTSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVHLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLISQTSSPLSQNDSCTGRSADLLLPSADTSRRRHDSLPDPGTASRADRFRVQEEPSETKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRTMAASAASMIETKSSKPVPKPRVGMRKSALEPPDSDQEAPSHASVSWIVDPKPDSKRSLSTN
Protein: Uncharacterized protein C17G6.02c (O13780)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000269|PubMed:10759889}; Multi-pass membrane protein {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Transposon Tf2-11 polyprotein
Sequence:
MYYDNAFGYIPAHWVTILAVILFSIAFILHVACLAFTRKWLVIVPIIGTIGELAGWACRLDASYNPDDYNAFLGQIIALIIAPVFYSAQAYVLFHHIVLLYGPRFSVLSPKLYGGIFITFDIIALILQAAGGGVAGGADSGSQLQTQGSQIMLGGICFQLFTIVVFSILFSIFFIALYTHHPIRPSTGRREPDVPYTRVRTMSCNCLALATFAMVVRSVYRVIELAQGWEGAVITHEVWFDIFDFIPMIFTSALLIPSLYPALERSKLPFTEKHVSSMEYAPSEYGPSEYGPSINDITNMSAVIYPDSFLAPKDPKKSFSSEEL
Protein: Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1) (Q8R0Y6)
Organism: Mus musculus (Mouse)
Function: Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide. May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P28037}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- C-1-tetrahydrofolate synthase, cytoplasmic
- Dihydrofolate reductase
- Serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
- Formimidoyltransferase-cyclodeaminase
- Methionine synthase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
- Aminomethyltransferase, mitochondrial
Sequence:
MKIAVIGQSLFGQEVYCQLRKEGHEVVGVFTIPDKDGKADPLGLEAEKDGVPVFKFPRWRARGQALPEVVAKYQALGAELNVLPFCSQFIPMEVINAPRHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFTIFWADDGLDTGDLLLQKECDVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGTAPRRPQPEEGATYEGIQKKETAMINWDQPAEAIHNWIRGNDKVPGAWTEACGQKLTFFNSTLNTSGLVAQGEALPIPGAHRPGLVTKAGLILFGNDDRMLLVKNIQLEDGKMMPASQFFKGSASSALELTEEELATAEAVRSSWMRILPNVPEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMATTFGDFIQLLVRKLRGEDGESECVINYVEKAVKKLTLQMPYQLFIGGEFVDAEGAKTYSTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDQFVQKVVEEVGKMKIGNPLDRDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRIKTVTFEY
Protein: Probable E3 ubiquitin-protein ligase HECTD2 (EC 2.3.2.26) (HECT domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECTD2) (Q5U5R9)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Interaction partners:
Sequence:
MSEAVRVPSPATPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQISTFSSFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSSEMKAPVLPEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTIEDSGINAKFVNAVYDTLLNTPQDVQKTVLKGIINSLLREWKGPRTKDDLRAYFILLQNPQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKLSQKRFKQLVERLLQFISLRLFPAKPEEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE
Protein: Prophage repressor RacR (Rac prophage repressor) (P76062)
Organism: Escherichia coli (strain K12)
Function: Repressor protein for rac prophage.
Interaction partners:
- Putative transcriptional regulator YdaS
- Transcriptional regulator YdaT
- HTH-type transcriptional regulator DicA
- Uncharacterized protein YdaF
- Uncharacterized protein YdaU
Sequence:
MLSGKDLGRAIEQAINKKIASGSVKSKAEVARHFKVQPPSIYDWIKKGSISKDKLPELWRFFSDVVGPEHWGLNEYPIPTPTNSDTKSELLDINNLYQAASDEIRAIVAFLLSGNATEPDWVDHDVRAYIAAMEMKVGKYLKALESERKSQNITKTGT
Protein: ATP-binding cassette sub-family C member 9 isoform X8 (ATP-binding cassette, sub-family C (CFTR/MRP), member 9) (A0A0R4IAS5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MALSFCGNDRDSNAYSVDNGVLDNGCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNMRWILTFTLLFVHVCEIAEGIVSNTQMESNHLHLFMPAFMGFIAATTSVVYYHNIETANFPKLLLALFIYWILAFITKMIKLWKFAEASLGVQHLRFCITALLVVLYGLLMAVEINVIRVRKYVFFANPQRVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNPLIIGAHKRPIELKKIGKLPIAMRALTNYLRLKDSYEEQRNTEDPEKSPSIWKSMYRAFGGSILLSSTFRYMADLLGFAGPLCISGIVEHLHNSTEIDRTNKTGNMTFGVYFMSSTELLQNTSVLAVLLFLALVLQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNMSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYYLLGNSALIGAGVILLLAPVQYLIATKLADIQKSTLDYSTDRLKKTTEILKGIKLLKLYAWENIFCDRVEETRGKELTSLKTFALHTSMSIFMNAAIPIAAVLATFVTHAYIEEDRLSPAKAFASLALFHILVTPLFLLSTVVRFAVKALVSVQKLSEFLQSDEIGDDSWRNGDMCMSLEVGKKYKYQGDTKAINRKGRYRMDNYEQPVRRQLRPSETEDVAVQVNDGFFTWGSNLSTLSDINIRIPTGQLTMIVGQVGCGKSSLLLAMLGEMQTISGKVYWSNKNRYSVAYATQKSWLLNATVEENITFGSPFNKQRYKAVIDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLIHADWIIAMKDGSVLREGTLKDIQTHDVELYEHWKTLMNRQDQELEKDTDLESQTTLERKTLRRAFYSREAKNHVDDEDEEEEVEEEDDDNMSTTTSRRSKIPWKMCCCYLSSGGFLMVFLMVSSKLAKHSVMVAIDYWLAAWTSSNPHNQSFVNSSFNHTLNDDATQIAEHRSYVPVFIILCAAAIALCLITSLTVEFLGVAAATNLHHNLLNKIIHAPIRFFDVTPLGQILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGVIAFVTPAFLIALVPLAVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRMLELTDTNNTAYLFLSAANRWLEVRTDYLGAVIVLTAAVAAIWSTSPSGLVGLGLTYALTLTNYLNWVVRNLADLEVQMAAVKKVNSFLSTESENYEGSMDVSQVPEDWPQHGEITIHDLCVRYDSMLKPVLKHVNAHINPGQKVGICGRTGSGKSSLSLAFFNMVDVFEGKIVIDGIDICKLPLQTLRSRLSIILQDPVLFSGSIRLNLDPERTCTDDRLWEALEIAQLKNMVKALPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHLVSSILEAEQVLVFSSGILVENDSAINLLAQEDSLFGILVRTHK
Protein: FBXL18 protein (Q96D16)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MHAVPRGFGKKVRVGVQSCPPLLGPGVPPALLRVLVSAEEPALPGTPRADWVQLLLRHAPQRARHPQLAPTLQPRTECRGLGGGRHRPAGLPAAPDARTAAQRPYGLRAGQYRPAVPAVAVPVAGQPGHDGEGGVHARALRHVEALQAAEGPQAGAALLQRQRPVLPGAEPVPLAAAPVPGLSQRHPPARCRAGLHGSLPAGCHVPPVHRGVPRHLQEPAAVASPQLPGRAARVKRRHLPSAPRGPDRRHPGRPPGAPG
Protein: DNA repair protein RAD52 homolog (P43352)
Organism: Mus musculus (Mouse)
Function: Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA repair protein RAD51 homolog 1
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- Fanconi anemia group M protein homolog
- Replication protein A 70 kDa DNA-binding subunit
- DNA repair and recombination protein RAD54-like
- Transcriptional regulator ATRX
- Replication protein A 14 kDa subunit
- Structure-specific endonuclease subunit MUS81
- Breast cancer type 2 susceptibility protein homolog
- Breast cancer type 1 susceptibility protein homolog
Sequence:
MAGPEEAVHRGCDNHPPFVGGKSVLLFGQSQYTADEYQAIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVKVQLKDGSYHEDVGYGVSEGLRSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYLRSLNKLPRQLPLDVDLTKTKREDFEPSVEQARYNSCRQNEALGLPKPQEVTSPCRSSPPHDSNIKLQGAKDISSSCSLAATLESDATHQRKLRKLRQKQLQQQFREQMETRRQSHAPAEEVAAKHAAVLPAPPKHSTPVTAASELLQEKVVFPDNLEENLEMWDLTPDLEDIIKPLCRAEPAQTSATRTFNNQDSVPHIHCHQKPQEKPGPGHLQTCNTNQHVLGSREDSEPHRKSQDLKKRKLDPS
Protein: Mitochondrial import receptor subunit TOM40 homolog 2 (Translocase of outer membrane 40 kDa subunit homolog 2) (A1Z6L1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Channel-forming protein essential for import of protein precursors into mitochondria.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:15304338}; Multi-pass membrane protein {ECO:0000269|PubMed:15304338}.
Interaction partners:
- Metaxin-1 homolog
- TOMM20-like protein 1
- Mitochondrial import receptor subunit TOM7 homolog
- Mitochondrial import receptor subunit TOM22 homolog
- LD34461p
- SAM50-like protein CG7639
- FI03495p
- AT01806p
- Protein clueless
- Mitochondrial import inner membrane translocase subunit Tim13
Sequence:
MGNVMASTADAESSRGRGHLSAGLRLPEAPQYSGGVPPQMVEALKAEAKKPELTNPGTLEELHSRCRDIQANTFEGAKIMVNKGLSNHFQVTHTINMNSAGPSGYRFGATYVGTKQYGPTEAFPVLLGEIDPMGNLNANVIHQLTSRLRCKFASQFQDSKLVGTQLTGDYRGRDYTLTLTMGNPGFFTSSGVFVCQYLQSVTKRLALGSEFAYHYGPNVPGRQVAVLSAVGRYAFGDTVWSCTLGPAGFHLSYYQKASDQLQIGVEVETNIRQQESTATVAYQIDLPKADLVFRGSLDSNWLISGVLEKRLQPLPFSLAISGRMNHQKNSFRLGCGLMIG
Protein: Lysine-specific demethylase 3 (EC 1.14.11.65) (Q9VHC5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000269|PubMed:28701701, ECO:0000269|PubMed:29339751}. Cytoplasm {ECO:0000269|PubMed:28701701}.
Interaction partners:
- JmjC domain-containing histone demethylation protein 1
- Histone H3
- Histone H3.3A
- Probable lysine-specific demethylase 4B demethylase 4B)
- Probable lysine-specific demethylase 4A demethylase 4A) demethylase 4A)
- HSPB1 associated protein 1
- 2-oxoglutarate and iron-dependent oxygenase JMJD4 homolog
- Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
- Jumonji C domain-containing protein 5
- Possible lysine-specific histone demethylase 1
Sequence:
MSQKELAALVATRTSRKRTISSTSFSISTRTDPKSIIEIHIFNDSLPIKRACCEVENPTLKAEQRVQQEEESLGQVPPLTEEEQQRHDEFRNSGSIFLQDLPCFKLQQAQPIAGSSPIPKCRECRRRNLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGFPNPYSEPSPEDIAIWQPDKNTPPTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSLHQNTDGTIAWKKAVKGTREICDVCDTTLFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKGCDEYHWLLCSDPSGPQEHVLTELMLTQIIAGDALNVLGRLLHEVRTLWQVPQVCGCLLSKQAIEDAQSKEVIQDMIKESQLKQHTSYSSLASEQKVHQQQRLDQLHATKLEFARELGVDYVPGRVWTKETLGKDPITTAFDNLKHINFLRKGLAGLRRFLPPRTMTFAYSTQLAPGVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLDLWHPQAFCRDFGDKPNDLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPMLLKLKDWPPGDDFAEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSALHPDKGTTNLHLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVLPGALWHIFPARDADKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGAPHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHAIKDCCTILTRAVDERLNAELTKLNAD