wanglab/gogpt-training-data huggingface dataset:
Protein: Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2) (Rec1.3) (VZG-1) (P61793)
Organism: Mus musculus (Mouse)
Function: Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain.
Subcellular location: Cell surface {ECO:0000269|PubMed:8922387}. Cell membrane {ECO:0000269|PubMed:18157949, ECO:0000269|PubMed:21821728, ECO:0000269|PubMed:9600933, ECO:0000305|PubMed:8922387}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q92633}. Endosome {ECO:0000250|UniProtKB:Q92633, ECO:0000305|PubMed:18157949}. Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment (PubMed:18157949). Colocalizes with RALA in endocytic vesicles after LPA treatment. {ECO:0000250|UniProtKB:Q92633, ECO:0000269|PubMed:18157949}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-12
- Lysophosphatidic acid receptor 4
- Lysophosphatidic acid receptor 6
- Lysophosphatidic acid receptor 5
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Adhesion G protein-coupled receptor E5
- Guanine nucleotide-binding protein G
Sequence:
MAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
Protein: Tubulin-folding cofactor C (AtTFCC) (TFC C) (Protein PORCINO) (Q9SMR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential tubulin-folding protein involved in the final step of the tubulin folding pathway. Required for continuous microtubule cytoskeleton organization, mitotic division, cytokinesis, and to couple cell cycle progression to cell division in embryos and endosperms. Not essential for cell viability. Binds probably to the multimeric supercomplex, stimulating GTP hydrolysis by the bound beta-tubulin and the release of the alpha-/beta-tubulin heterodimer.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11959844, ECO:0000269|PubMed:12225668}. Note=Not associated with microtubular arrays.
Interaction partners:
- Tubulin-folding cofactor A
- Rac-like GTP-binding protein ARAC9
- At1g79390
- Tubulin alpha-5 chain
Sequence:
MEDDGQSSVAETLDPALQKKHHDMLERLSARHQARKSDSPDSSSSSSSTLESTSSFLAKFSDSKRSIESRIAESRLASSSTDSSKLKSDLAEISVAIDNLEKLLAENSYFLPSYEVRSSLKIVSDLKQSLDILSGELVPKKKFSFKSKSTTKKPESKLPEIQKPDVVLPPKLVPVRDSPGLRNKHGETLVKSFEGSSIGEFTLSDLDSCQVKLTGTVNALFLHRLKKCSVYTGPVIGSILIDDVEDCVLVLASHQIRIHCARKSDFYLRVRSRPIIEDSNGVRFAPYCLDYKGIDEDLKTAGLEEETNNWANVDDFRWLRAVQSPNWSLLPEEERVSLLTISGDS
Protein: Mitogen-activated protein kinase 2 (EC 2.7.11.24) (PCM) (O42781)
Organism: Pneumocystis carinii
Function: Serine-threonine protein kinase which may be involved in pheromone signaling. Functionally complements the MAPK pheromone signaling pathway in S.cerevisiae.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P27638}.
Interaction partners:
Sequence:
MTASSRNVRFNVSDDYEILDVIGEGAYGIVCSAIHKPSGQKVAIKKISPFDHSMFCLRTLREMKLLRYFNHENIISILDIQQPQDFESFSEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQILRALKAMHSADILHRDLKPSNLLLNANCDLKVCDFGLARSAVSTEDSSSFMTEYVATRWYRAPEIMLTFKEYTKAIDIWSVGCILAEMLSGRPLFPGKDYHHQLMLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKRVSFASIFPRANPLALDLLEKLLAFNPAKRVTAEEALQHNYLEPYHDPDDEPTAPPISPSFFDFDRIKDSLTKNDLKILIYKEIMSMNN
Protein: N(6)-L-threonylcarbamoyladenine synthase (EC 2.3.1.234) (E5RIL9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLILTKTAGVFFKPSKRKVYEFLRSFNFHPGTLFLHKIVLGIETSCDDTAAAVVDETGNVLGEAIHSQTEVHLKTGGIVPPAAQQLHRENIQRIVQEALSASGVSPSDLSAIATTIKPGLALSLGVGLSFSLQLVGQLKKPFIPIHHMEAHALTIRLTNKVEFPFLVLLISGGHCLLALVQGVSDFLLLGKSLDIAPGDMLDK
Protein: Gfi1.1 protein (Growth factor independent 1.1) (Growth factor independent 1A transcription repressor a) (Q501T1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPRSFLVKSKRAHSYHQPRYLDDNCISIEKLLTCQESQTGQAPESPLDVGNQSPKASMVCTADQSSQQFPLSCEGSVCDRSSDYEDFWRPLSSGTSPDLDKCPVPSPDDSQPFDMSFRPYVWSHSSSELRHLIQSCNRVSVDSDSSVGVYDAMDRRSSAHLLIQPTQSRRFYQDYGSLTPNLLDNRGFYTDFKMSTKVAETDSESDMTCTRLQLSGSYKCIKCTKVFSTPHGLEVHVRRSHSGTRPFACEICGKTFGHAVSLEQHKAVHSQERVFSCKICDKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHKETQHGLK
Protein: Naringenin 8-dimethylallyltransferase 2, chloroplastic (SfN8DT-2) (EC 2.5.1.70) (B1B5P4)
Organism: Sophora flavescens (Ku shen)
Function: Involved in the biosynthesis of sophoraflavanone G (SFG). Can use flavanones (naringenin, liquiritigenin and hesperetin) as substrates, but not flavonols or isoflavones. Shows a strict specificity for dimethylallyl diphosphate.
Subcellular location: Plastid, chloroplast membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGFVLPASFPGASSITTGGSCLRSKQYAKNYYASSYVTTLWHKKGKIQKEYCAVIFSRHNLKQHYKVNEGGSTSKECEKKYVVNAISEQSFEYEPQARDPKNIWGSVNDALDTFYKFCRPYAIFSVVLGATFKSLVAVERLSDLSLAFFIGWLQVVVAVICIHIFDVGLNQLCDIEIDKINKPDLPLASGNLSFRNVVIITASSLILGLGFAWIVGSWPLFWTVFICCMFAAAYNVDLPLLRWKKYPVLTAISFIANVAVTRSLGFFLHMQTCVFKRPTTFPRPLIFCTAIVSIYAIVIALFKDIPDMEGDEKFGIQSLSLRLGPKRVFWICVSLLEMAYGVTILVGATSPILWSKIITVLGHAILASVLWYHAKSTDLTSNVVLQSFYMFIWKLHTAEYCLIPLFR
Protein: Folate receptor gamma (FR-gamma) (Folate receptor 3) (P41439)
Organism: Homo sapiens (Human)
Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.
Subcellular location: Secreted.
Interaction partners:
- Glutamate carboxypeptidase 2
Sequence:
MDMAWQMMQLLLLALVTAAGSAQPRSARARTDLLNVCMNAKHHKTQPSPEDELYGQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPTCKRHFIQDSCLYECSPNLGPWIRQVNQSWRKERILNVPLCKEDCERWWEDCRTSYTCKSNWHKGWNWTSGINECPAGALCSTFESYFPTPAALCEGLWSHSFKVSNYSRGSGRCIQMWFDSAQGNPNEEVAKFYAAAMNAGAPSRGIIDS
Protein: Na(+)/H(+) antiporter subunit A (Mrp complex subunit A) (Multiple resistance and pH homeostasis protein A) (Q9K2S2)
Organism: Bacillus subtilis (strain 168)
Function: Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance. MrpA is required for initiation of sporulation when external Na(+) concentration increases. Also transports Li(+) but not K(+), Ca(2+) or Mg(2+).
Subcellular location: Cell membrane {ECO:0000269|PubMed:17693497}; Multi-pass membrane protein {ECO:0000269|PubMed:17693497}.
Interaction partners:
- Na
- Na
- Na
- Na
- Na
- Na
- Iron-sulfur cluster carrier protein
- Probable inorganic carbon transporter subunit DabB
Sequence:
MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIYFLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYLSKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSRYGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILLGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWIVSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTVAAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFSMAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLFKTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYPTLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNRLYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMAKIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLVIETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDSIASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGKSGE
Protein: Eukaryotic translation initiation factor 5 (eIF-5) (Q22918)
Organism: Caenorhabditis elegans
Function: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit B
- protein-synthesizing GTPase
- SUI1 domain-containing protein
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit D
Sequence:
MALNVNRAVADPFYRYKMPKLSAKVEGKGNGIKTVISNMSEIAKALERPPMYPTKYFGCELGAQTNFDAKNERYIVNGEHDANKLQDILDGFIKKFVLCKSCENPETQLFVRKNNIKSKCKACGCSFDIDLKHKLSTFIMKNPPKIDVDFSKAEQKNGKKTSGADAAAAVAADIIHNSDKGSSNDDDDDDWEPEPVEPNGMLSAGMGKLVLDKDLEKSEEQRLDMLHTFFLKAKEEDRISDAKGQTALRDEAERLELKQKASLLLANVFLDEKVITDKQISKHRNLLLRFTLNDKKAQRYLLGGVEQVIHKHEAELLSKSAHIIKSLYDEDVCEEDSLISWGEKPSSKYVSKSFAKKIIENSQPVLNWLKEAEEETEEESDDEIAFGGDVKESEFLRQQKEKAAREAQQKSAKATNGNAAAASGANDEEDLDIDDI
Protein: Protein NRT1/ PTR FAMILY 2.4 (AtNPF2.4) (Probable nitrate excretion transporter 5) (Protein NAXT1-like 4) (Q9M173)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transporter involved in a passive nitrate efflux.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- S-type anion channel SLAH1
- S-type anion channel SLAH3
Sequence:
MANSDSGDKEAHRSSKHGGWITLPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGISLLTLIASLDYLRPRPCETGSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQYKKPKEQGRFFNWYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEHDQPLGSPYTSLVRVLVAATMKRKAVISYKDEDYHHRELEKETKTYVAMPSKSFRFLNRAALKTEGDSNNNMWRLCSVQEVEDFKAVLRLVPLWTSVMFLSAPLAVQMSMTVLQAMVMDRKLGPHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLIRKPLTPLQKVGIGHVLTILSMAISAVVEAKRLKTVENSHLMSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTALIDVIQRTTKWLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCSWFYKYRNLKNDDHEQDLKDVTN
Protein: Apoptosis regulator ced-9 (Cell death protein 9) (P41958)
Organism: Caenorhabditis elegans
Function: Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway.
Subcellular location: Perikaryon {ECO:0000269|PubMed:26074078}. Synapse {ECO:0000269|PubMed:26074078}. Endomembrane system {ECO:0000269|PubMed:10688797, ECO:0000269|PubMed:9027313}; Peripheral membrane protein. Mitochondrion membrane {ECO:0000269|PubMed:10688797, ECO:0000269|PubMed:9027313}; Peripheral membrane protein {ECO:0000269|PubMed:10688797, ECO:0000269|PubMed:9027313}. Cytoplasm {ECO:0000269|PubMed:17021039}. Note=Intracellular membranes, mitochondrial, and perinuclear region (PubMed:10688797, PubMed:9027313). Localizes to synapses of DD motor neurons (PubMed:26074078). Synaptic localization is dependent on axonal mitochondria (PubMed:26074078). {ECO:0000269|PubMed:26074078}.
Interaction partners:
- Cell death protein 4
- Programmed cell death activator egl-1
- Cell death protein 3
- Beclin homolog
- Secreted protein
- Transmembrane GTPase fzo-1
- Cytochrome c 2.1
- Probable cytochrome c 2.2
- Mitochondrial 2-oxoglutarate/malate carrier protein
- Putative inactive caspase B
Sequence:
MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK
Protein: CRIB domain-containing protein RIC1 (ROP-interactive CRIB motif-containing protein 1) (Target of ROP protein RIC1) (F4IVV0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as downstream effector of Rho-related GTP binding proteins of the 'Rho of Plants' (ROPs) family. Participates in the propagation of ROP GTPase signals in specific cellular responses. Required for cortical microtubule organization. Promotes microtubule bundling and formation of well-ordered microtubule arrays in the neck region of pavement cells. This restricts cell lateral expansion to generate the narrow neck morphology of pavement cells. Its function is inhibited when it interacts with activated ARAC4/ROP2. Represses ARAC4/ROP2 activation and antagonizes the RIC4-actin pathway that promotes the assembly of cortical actin microfilaments. Acts as downstream effector of ARAC3/ROP6 which functions in a signaling pathway that negatively regulates clathrin-mediated endocytosis and internalization of PIN1 and PIN2. Required for the asymmetric auxin distribution during root gravitropism and vascular patterning. Positively regulates auxin responses, but negatively regulates ABA responses during lateral root development and primary root elongation.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15766531}. Cytoplasm {ECO:0000269|PubMed:11752391, ECO:0000269|PubMed:15766531, ECO:0000269|PubMed:23078108}. Note=Associates with and promotes the organization of cortical microtubules in leaf epidermal pavement cells. Localizes to punctate loci in the cytoplasm of root cells. {ECO:0000269|PubMed:23078108}.
Interaction partners:
- Rac-like GTP-binding protein ARAC3
- Rac-like GTP-binding protein ARAC5
- Rac-like GTP-binding protein ARAC4
- non-specific serine/threonine protein kinase
- Guanine nucleotide exchange factor SPIKE 1
- Protein DETOXIFICATION 34
- Rop guanine nucleotide exchange factor 12
- Auxin-binding protein 1
- Rac-like GTP-binding protein ARAC11
- Rac-like GTP-binding protein ARAC10
Sequence:
MATTMKGLLKGLRYITQIFDEEKEQEMQIGFPTDVKHVAHIGSDGPTNTTPSWMNDFKTQEHEKGQVVSRGNSNKYNPQGTNQRGAGLKELLPSNTNEKPKQKTRRKPGGAASPNHNGSPPRKSSGNAASSDEPSKHSRHNRSAHGSTDSSNDQEPSVRRRRGGIPAPDTEVPNQIPDGSAPPRKATSRPRKLKGSSAGGEGSIKKSSKGKPENSVDTTCNDII
Protein: GTPase Obg (EC 3.6.5.-) (GTP-binding protein Obg) (Q5F5D9)
Organism: Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate; the half-life of the GTP-bound state is about 50 minutes. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01454, ECO:0000269|PubMed:26122105}. Note=Associates with 50S ribosomal subunits. A small amount may associate with the cell inner membrane. {ECO:0000269|PubMed:26122105}.
Interaction partners:
- Ribosomal silencing factor RsfS
- Large ribosomal subunit protein bL27
- Large ribosomal subunit protein bL21
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein bL20
- Large ribosomal subunit protein bL19
- GTPase Der
- Large ribosomal subunit protein bL17
- Large ribosomal subunit protein bL32
- Large ribosomal subunit protein bL9
Sequence:
MKFIDEAKIEVAAGKGGNGATSFRREKFVPRGGPDGGDGGKGGSVWAEADENTNTLVEYRFVKRYQAKNGEKGHGSDRYGAGADDIVLKMPVGTLIRDLDTDEIVADLTYHGQRVCLAKGGKGGLGNIHFKSSVNRAPKQSTPGEEGETRSLQLELKVLADVGLLGMPNAGKSTLITAVSAARPKIANYPFTTLHPNLGVVRIDENHSFVMADIPGLIEGAAEGAGLGHRFLKHLSRTGLLLHVVDLAPFDETVNPAEEALAIINELRKYDEELYGKPRWLVLNKLDMLDEEEARARTAAFLEAVGWDYPEPDDRFQFDMETPRLFQISALTHQGTQELVHQINQYLAEKKRIEAEKAEAEKAAANVEIIEQQPKTDTGVFKPE
Protein: Large ribosomal subunit protein eL33w (60S ribosomal protein L35a-1) (Q9LMK0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL24z
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein eL31y
- Small ribosomal subunit protein eS24z
- Large ribosomal subunit protein eL43y
- At1g43860
Sequence:
MVKGRQGERVRLYVRGTILGYKRSKSNQYPNTSLVQVEGVNTTEEVSWYKGKRMAYIYKAKTKKNGSHYRCIWGKVTRPHGNSGVVRAKFTSNLPPKSMGSRVRVFMYPSNI
Protein: High affinity choline transporter 1 (hCHT1) (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7) (Q9GZV3)
Organism: Homo sapiens (Human)
Function: Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent.
Subcellular location: Presynaptic cell membrane {ECO:0000269|PubMed:11027560, ECO:0000269|PubMed:12969261, ECO:0000269|PubMed:27569547}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BGY9}. Early endosome membrane {ECO:0000269|PubMed:12969261, ECO:0000269|PubMed:15953352}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:12969261}; Multi-pass membrane protein {ECO:0000305}. Note=Localized at the neuromuscular junction (PubMed:27569547). Localization at the plasma membrane is transient due to the rapid endocytosis of SLC5A7/CHT1 via the clathrin-mediated pathway, where it localizes to early endosomes (PubMed:12969261, PubMed:15953352). Also localized to synaptic vesicles where it is likely mobilized to the cell surface by exocytosis (PubMed:12969261). {ECO:0000269|PubMed:12969261, ECO:0000269|PubMed:15953352, ECO:0000269|PubMed:27569547}.
Interaction partners:
- Vesicular acetylcholine transporter
- Kinesin-like protein KIF23
- Choline O-acetyltransferase
- E3 SUMO-protein ligase RanBP2
Sequence:
MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
Protein: Collagen alpha-2(IV) chain [Cleaved into: Canstatin] (P08122)
Organism: Mus musculus (Mouse)
Function: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000255|PROSITE-ProRule:PRU00736}.
Interaction partners:
- Collagen alpha-1
- Col4a5 protein
- Collagen alpha-3
- CD44 antigen
- Collagen alpha-4
- Collagen, type IV, alpha 6
- Platelet glycoprotein VI
- Serpin H1
- Integrin alpha-1
- Integrin beta-5
Sequence:
MDRVRFKASGPPLRGWLLLATVTVGLLAQSVLGGVKKLDVPCGGRDCSGGCQCYPEKGARGQPGAVGPQGYNGPPGLQGFPGLQGRKGDKGERGVPGPTGPKGDVGARGVSGFPGADGIPGHPGQGGPRGRPGYDGCNGTRGDAGPQGPSGSGGFPGLPGPQGPKGQKGEPYALSKEDRDKYRGEPGEPGLVGYQGPPGRPGPIGQMGPMGAPGRPGPPGPPGPKGQPGNRGLGFYGQKGEKGDIGQPGPNGIPSDITLVGPTTSTIHPDLYKGEKGDEGEQGIPGVISKGEEGIMGFPGIRGFPGLDGEKGVVGQKGSRGLDGFQGPSGPRGPKGERGEQGPPGPSVYSPHPSLAKGARGDPGFQGAHGEPGSRGEPGEPGTAGPPGPSVGDEDSMRGLPGEMGPKGFSGEPGSPARYLGPPGADGRPGPQGVPGPAGPPGPDGFLFGLKGSEGRVGYPGPSGFPGTRGQKGWKGEAGDCQCGQVIGGLPGLPGPKGFPGVNGELGKKGDQGDPGLHGIPGFPGFKGAPGVAGAPGPKGIKGDSRTITTKGERGQPGIPGVHGMKGDDGVPGRDGLDGFPGLPGPPGDGIKGPPGDAGLPGVPGTKGFPGDIGPPGQGLPGPKGERGFPGDAGLPGPPGFPGPPGPPGTPGQRDCDTGVKRPIGGGQQVVVQPGCIEGPTGSPGQPGPPGPTGAKGVRGMPGFPGASGEQGLKGFPGDPGREGFPGPPGFMGPRGSKGTTGLPGPDGPPGPIGLPGPAGPPGDRGIPGEVLGAQPGTRGDAGLPGQPGLKGLPGETGAPGFRGSQGMPGMPGLKGQPGFPGPSGQPGQSGPPGQHGFPGTPGREGPLGQPGSPGLGGLPGDRGEPGDPGVPGPVGMKGLSGDRGDAGMSGERGHPGSPGFKGMAGMPGIPGQKGDRGSPGMDGFQGMLGLKGRQGFPGTKGEAGFFGVPGLKGLPGEPGVKGNRGDRGPPGPPPLILPGMKDIKGEKGDEGPMGLKGYLGLKGIQGMPGVPGVSGFPGLPGRPGFIKGVKGDIGVPGTPGLPGFPGVSGPPGITGFPGFTGSRGEKGTPGVAGVFGETGPTGDFGDIGDTVDLPGSPGLKGERGITGIPGLKGFFGEKGAAGDIGFPGITGMAGAQGSPGLKGQTGFPGLTGLQGPQGEPGRIGIPGDKGDFGWPGVPGLPGFPGIRGISGLHGLPGTKGFPGSPGVDAHGDPGFPGPTGDRGDRGEANTLPGPVGVPGQKGERGTPGERGPAGSPGLQGFPGISPPSNISGSPGDVGAPGIFGLQGYQGPPGPPGPNALPGIKGDEGSSGAAGFPGQKGWVGDPGPQGQPGVLGLPGEKGPKGEQGFMGNTGPSGAVGDRGPKGPKGDQGFPGAPGSMGSPGIPGIPQKIAVQPGTLGPQGRRGLPGALGEIGPQGPPGDPGFRGAPGKAGPQGRGGVSAVPGFRGDQGPMGHQGPVGQEGEPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEEEIKPYISRCSVCEAPAVAIAVHSQDTSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYFANKYSFWLTTIPEQNFQSTPSADTLKAGLIRTHISRCQVCMKNL
Protein: Programmed cell death protein 10-A (Q6PHH3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BUL8}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6NX65}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NX65}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6NX65}. Cell membrane {ECO:0000250|UniProtKB:Q6NX65}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NX65}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6NX65}.
Interaction partners:
- Cerebral cavernous malformations protein 2 homolog
- Krev interaction trapped protein 1
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase 25
- Serine/threonine-protein kinase 24
- MOB-like protein phocein
- CCM2-like scaffold protein.
- Sarcolemmal membrane-associated protein
- CTTNBP2 N-terminal-like b.
Sequence:
MTMEEMKNEADATSMVSMTLYAVMYPVFNELESVNLSAAQTLRAAFKKAEKENPGLTQDIIMKILEKKNVEINFTESLLRMAADDVEEYMIDRPEREFQDLNERARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKHSKSFSDTLKTYFKDGKAINVFASANRLIHQTNLILQTFKTVA