wanglab/gogpt-training-data huggingface dataset:
Protein: Epithelial sodium channel subunit gamma (Gamma-ENaC) (pithelial Na(+) channel subunit gamma) (Amiloride-sensitive sodium channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) (P37091)
Organism: Rattus norvegicus (Rat)
Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus (By similarity). Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:8188647, ECO:0000269|PubMed:9118951, ECO:0000269|PubMed:9351815}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51170}.
Interaction partners:
- Epithelial sodium channel subunit beta
- NEDD4-like E3 ubiquitin protein ligase.
- Epithelial sodium channel subunit alpha
- E3 ubiquitin-protein ligase NEDD4
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Serine/threonine-protein kinase Sgk1
- Cystic fibrosis transmembrane conductance regulator
- Sodium/hydrogen exchanger 3
- Aquaporin-2
- Prostasin
Sequence:
MAPGEKIKAKIKKNLPVRGPQAPTIKDLMHWYCMNTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTPPRFFKLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNKENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLIHQQNEYPFIEDVGMEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWHKAKDWWARRQTPPSTETPSSRQGQDNPALDTDDDLPTFTSAMRLPPAPGSTVPGTPPPRYNTLRLDRAFSSQLTDTQLTNEL
Protein: Uncharacterized protein (O05838)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Decaprenyl diphosphate synthase
- DNA repair protein RecO
- Putative amidase AmiA2
- Probable conserved transmembrane protein
- Conserved alanine valine rich protein
- Uncharacterized protein Rv0497
- Probable conserved transmembrane protein
- Uncharacterized protein Rv1486c
- Uncharacterized protein Rv1109c
- Possible conserved secreted protein
Sequence:
MPSLPDRLASILRDVLPAEEEPDGALTVRHDGTFASLRVVSIAEDLELVSLTQILAWDLPLTKRLAEQVAKQARDINFGSVSLREKVSEKAARRSSGRPASNTADVMLRYNFPGTGLTDDALRTLILLVLETGATIRSALVG
Protein: Fgr12p (Q59P58)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MVLNFDEELNLQEYTISNQGSKRTRSVKPDNISNILEEAPNEIPNNQSNVDFTNSELEYLTCHSLTAHAFENSEIDVSPAISNQTHQSLRPSFSSEYDTDTTDLIGFVEQNTHHAVTTSNRYNKSSEELVFQESIDYSTFLENVLERENNNSIGNIESSREFDNAAANLFSSENCEHDLLLLQHELQETGIPIEQFQPQSYIYNEENDDFLNQSPAQVNTAATITTTTTSSVSVLSLVKSPCHVTSNYEDFVTSPIYEWPNDESGVSVDLLNTINVRVASLEPKTVSDAVRKTIREEFVIQDMFLNGQSPLPPEIPRSIRKKSDRDVEWTPLSVYKAYTNIKSPTNGKEAYNHLVPYTSCIGTLNYRPKDHAAWKRAPNRRR
Protein: Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2) (Q92953)
Organism: Homo sapiens (Human)
Function: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q63099}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q63099}. Perikaryon {ECO:0000250|UniProtKB:Q63099}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63099}. Note=Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons. {ECO:0000250|UniProtKB:Q63099}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Voltage-gated potassium channel subunit beta-3
- Potassium voltage-gated channel subfamily B member 1
- Voltage-gated potassium channel subunit beta-2
- Voltage-gated potassium channel subunit beta-1
- Vesicle-associated membrane protein-associated protein A
- Vesicle-associated membrane protein-associated protein B/C
- Delayed-rectifier potassium channel regulatory subunit KCNS1
Sequence:
MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETSM
Protein: Autophagy-related 17, isoform B (Autophagy-related 17, isoform C) (FI18010p1) (Q7KTS2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Autophagy-related 1, isoform B
- Autophagy-related protein 13 homolog
- Autophagy-related protein 101
- Autophagy-related 16, isoform F
- Autophagy-related 14
- Beclin-1-like protein
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Autophagy protein 5
- Autophagy protein 12-like
- non-specific serine/threonine protein kinase
Sequence:
MMLYVFHVDVGRMLSFDMNVALQPVEHLKETIQKLHNIPAANIVLLVSGGEMLTHSTQVSCYSAGTDTNPIYMFLTGDERLPPTIYNSDADNELRRQVEESHRLPPALETVRQRAQLAQHMRELARKEEDQCERLVHEQHLQQQGWSAVVANMEDLTNEFCDRFQNFCSFFDRHLQKRESFLELLRNFPDDLKQLGRIPILPDLMSLAEADFHGFDELLDNDDVFTAQQQPTPQQQALTESSQADSPNKKLKMGDEVETESGEQTERGVQTLTSSSSLARRPNLNLLQWISSKGNHRALQLMSDECIQGLDVFSVEIYEKLKEEVNQIIKLANQADVKEIKGLGDRLCKLEEFKFRIKKMVQEQKEQALALQQNEARAQNLRDNSVLPDLCLSHRSQLQVMLDNHIKIREYCRCIANSKDELGWNLHTRLRRIVWIENGMSEFDNRLLFNHRCLRRAERHICIIEQIHRAPSTYVSAVAEVVRRKIFSDEFRQWATRLSADFDRIHSEELSRRRDFNASFEGHFLNILFPGMGDMPPAFANEHPLSFDTRLPSLSRSDMELLSSQLPELAGQLQLPDMKPVIDFFALRSDKNVEPDQEQERDIPLMAPRLAELQAQAAASDCETDTETEFEKLSTTSKCVATSISTSLVEQVAQSTATEDLLMLSAGTLTEENAGSFEKMRSDMESMTKLARACLAEARSNVGVFRSDVANYQDELQSELHLLRDKCNVLKMMCEEREQKLQEKLDEMSLKLQLAEQEKQAAVAQAREQLIHEHKTELESLRCRFKLMTSMERSPSDSSLEKIERPTSSASVVSANAGVDIDHLLAQQRQELLAQRERAISEAVDSERSLWQSRLLPLNSESVMANVGILKDMLADKERQLDQLREQNKILTQETYQLKTRLEMITNEDGNSWLKEKIDYLNKDKCRLEEELSQEKSRRQEMESSVAAMRSSAYDLNVGGPLTRSKSGVSSSHRSIALEGCARGDLVFVVWSMRHAQFMVVQDSLTLYFVHADSLASLQLTAPTSPTPSLDPSQTVVDINQIPLPYYAIGRVIDKEYCQARKDDNRYRVSRGSKFYRIKLAPLPSRNASRRERLESSSSIAAVVASPRDVIDAPSSNTSVYQSFKQRTVSITSVNEEDDESASLLSERCRYISVSEEDELHAAGGSMPAVTAAVATGTSTAASSATPITTAAPVAGGPTSTAPTAATQAQSVITEQPTASSKLKLDLLLASADIITQPLTQQPHQQRQELDQPAEAESTAPVAETSPNQTIQPEDPDPEPETITIYVPPNAPAVLTATPSTRASILASISAKPIISTDSMLPMSIGTAAISEDSDEYRSLEGKDDGDGDADDFPISE
Protein: ATP-dependent RNA helicase DRS1 (EC 3.6.4.13) (Deficiency of ribosomal subunits protein 1) (P32892)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-binding RNA helicase involved in ribosome assembly.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:1454790, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pescadillo homolog
- Nucleolar complex protein 2
- Ribosome biogenesis protein ERB1
- Ribosome biogenesis protein SSF1
- 25S rRNA
- 27S pre-rRNA
- Ribosome biogenesis protein YTM1
- Ribosome biogenesis protein 15
- Ribosome biogenesis protein MAK21
- Ribosome biogenesis protein RLP7
Sequence:
MVVGTKKYSNLDFVPTISDSEDDVPILDSSDDEKVEAKKTTKKRKGKNNKKKVSEGDNLDEDVHEDLDAGFKFDLDADDTTSNFQGWNFLAEGESNKDDAEAFVKKDVDLDKIIRRKGGLVKMAHIDSKQEEETEKEKVEKENDSDDEELAMDGFGMGAPMNNGDENQSEEEEEEEEKEEEEEEEEEQEEMTLEKGGKDDEIDEEDDSEEAKADFYAPETEGDEAKKQMYENFNSLSLSRPVLKGLASLGYVKPSPIQSATIPIALLGKDIIAGAVTGSGKTAAFMIPIIERLLYKPAKIASTRVIVLLPTRELAIQVADVGKQIARFVSGITFGLAVGGLNLRQQEQMLKSRPDIVIATPGRFIDHIRNSASFNVDSVEILVMDEADRMLEEGFQDELNEIMGLLPSNRQNLLFSATMNSKIKSLVSLSLKKPVRIMIDPPKKAATKLTQEFVRIRKRDHLKPALLFNLIRKLDPTGQKRIVVFVARKETAHRLRIIMGLLGMSVGELHGSLTQEQRLDSVNKFKNLEVPVLICTDLASRGLDIPKIEVVINYDMPKSYEIYLHRVGRTARAGREGRSVTFVGESSQDRSIVRAAIKSVEENKSLTQGKALGRNVDWVQIEETNKLVESMNDTIEDILVEEKEEKEILRAEMQLRKGENMLKHKKEIQARPRRTWFQSESDKKNSKVLGALSRNKKVTNSKKRKREEAKADGNGARSYRKTKTDRIADQERTFKKQKSTNSNKKKGFKSRR
Protein: Raftlin-2 (Raft-linking protein 2) (Q8CHX7)
Organism: Mus musculus (Mouse)
Function: Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q14699}; Lipid-anchor {ECO:0000250|UniProtKB:Q14699}.
Interaction partners:
Sequence:
MGCGLRKLEDPDESSPGKIFSTLKRPQVETKTEFAYEYALLDFTLQASTNPDVIKINSVLDIVAKVEDYYLKGYVVGAIHPVIQPVGQRKHLPASHLYRAVLSRLKLSPKHSAAGGQRRARLVMEECPLTCEAQANDAAKELMDKINAAAKRGMKFVGLVSQCYLPSMHCNGASHDGVAESGLHVRQDSQDNCKGWNEGALGGHLSESGVEEEPQHESGQHQTERNSSPSYANPKRGEAPDGKLYMVFNAFEEDAASWAYQEGVLSMKVTRKGAVISALDANWLELTTFYYKQGFSLIDSFVCWETPKGDQLPKSLEGFFIYEEEGSGVPGSNRRGNDAIVVEQWTVIEGCEIKTDYGPLLHTLAEFGWLLTSVLPTPILRHDSEGNLATKQVVFLQRPVTWNSAAQTPERKGSRLLKGEDRNKVSSRSLGLDTNASQAAGGRAPLEEGSLSPSRECWTKEERPAQSDSFSGFSSSDSVLRELDDGQFDQEEGVTQVTCM
Protein: Voltage-dependent calcium channel gamma-3 subunit (Neuronal voltage-gated calcium channel gamma-3 subunit) (Transmembrane AMPAR regulatory protein gamma-3) (TARP gamma-3) (O60359)
Organism: Homo sapiens (Human)
Function: Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Displays a somatodendritic localization and is excluded from axons in neurons. {ECO:0000250|UniProtKB:Q9JJV5}.
Interaction partners:
- Voltage-dependent calcium channel subunit alpha-2/delta-1
- Voltage-dependent calcium channel gamma-1 subunit
- Voltage-dependent L-type calcium channel subunit beta-4
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Voltage-dependent calcium channel gamma-7 subunit
- Voltage-dependent L-type calcium channel subunit beta-3
- Voltage-dependent L-type calcium channel subunit alpha-1F
- Glutamate receptor 2
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Voltage-dependent calcium channel subunit alpha-2/delta-4
Sequence:
MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTHSGLWRTCCLEGAFRGVCKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFHRSRHNVILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRAKSHSEFLKKSTFARLPPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKITMGTLLNSDRDHAFLQFHNSTPKEFKESLHNNPANRRTTPV
Protein: Protein Wnt-2 (Q92048)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P09544}. Secreted {ECO:0000250|UniProtKB:P09544}.
Interaction partners:
- Frizzled-4
- Frizzled class receptor 2
- Low density lipoprotein receptor-related protein 5
- Frizzled class receptor 7a
- Frizzled class receptor 1
- Secreted frizzled-related protein 1
- Frizzled-5
- Secreted frizzled-related protein 2
- Secreted frizzled-related protein 5.
- Frizzled class receptor 9b
Sequence:
MNFLPNGICFYLSVAICWFSSRVDASWWYMGTLGSQVMCDNIPGLINKQRQLCRQHPKVMQAIGAGIKNWIGECQHQFRTHRWNCNTMAREHNLFGRLLHRSSREAAFVYAISSAGMVYTLTRACSQGELENCSCDPGKKGSSRDAKGAFDWGGCSDHVDHAIKFTQVFIDAKERKERDARALMNLHNNRAGRKAVKRFMNLECKCHGVSGSCNVRTCWLAMADFRQTGDYLRKKYNNAIQVVMNQYGTGFTSAYRMLKRPNKNDLVYFEDSPDYCIWDHESGSVGTGGRVCNRTSRGTDSCEVMCCGRGYDTSRVSRTTKCECKFQWCCAVHCRDCQEEVDVHTCKTQS
Protein: IQ motif-containing GTPase-activating protein 2 (Ras GTPase-activating-like protein IQGAP2 isoform X1) (F1QAC1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MVKPQQSFRGSRMYHEDGANSLRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKQWMEACLEEQLPPTTELENGLRNGVYLGKLAKFFAPQLVSEKKIYDRDQSWYKLSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRKNMPKVIYCIHALSLYLYKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPAFSKIGGILANELSVDEAALHAAVFAINEAIDKGHAENTMTALRNPNALLRNTEKALAQVYQDTLSKAKRKKEDQASGRRSSVATEERDVYEELLTQQEIQSNVDLVNTSSAVQRLHQALEAEDQKALLASLKLPALGLVGVTDENACFYLEHFTSYRQHKDAGLGAQLGKDEIQKVITSCNEFAEAEKRKQEAVVAINSAIRRGIPEETVEELLNPEAQMPIVYHTAASLYQAELFSLQLGSKNKAGLSHEELCVAVEMLSAVSVLNEVLDTKDSVAVIEQLSDSPLGFSGMDADNLQRYTDTLIHLREESLARGQEFLTWNDVQKCIDTVNVQVHEEHERVIAIAEINEALHSGDPEKTLAALLLSTAKLQGVKAANAKHYHDLLLTTKDHICKSSGDESAVLWLDQIQEAIYTANQNQEDALRLAAAVADINRAVCEEDAKATMSALQCPDAGLRAVMPECAQIYQSQLHQLQSTQTQQGTSGSSWVQHKIKDKYDYFYNIECKEGTWVEPEHFVHDSSQLSREDIQNVLSSVTAEYNREQLWLANEPFIIQLQALIRGYLVRRAHQDRLEYLRKQEPSVIKLQASWKGYKQRSVYKERLRTFQDSASTVVKLQSLVKMWRAKRSYTKRLQYFRDHEKEIVKIQAFLKANKARVDYTTLTGSQHPPLSVVRKFVHLLEQSSLDLQEEQDVTRLREEVVTKIRANQQMEKDLNLMDIKIGLLVKNRITLQDVVSHSKKMKSKKNKMSKEDLAMGEKQGIKGLSKEKRKKLEAYQHLFYLLQTNPSYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFESALREEIKSKVDHIQEIVTGNPTVIKMVLSFYRGARGQNALRQLLGPVVKEIIEDKNLGINTNPVDIYKAWVNQLETATGEASKLPYEVTPEQALLHEEVRAKLESSNQVLRSVTDKVLGSIMSSLDNIPYGMRYIAKVLKDALHEKFPDATEDELLKIVGTLLYYRYMNPAIVAPDGFDIIDMTAGGQVHSEQRRNLASVAKMLQHAAANKLFEDESDHLTPMNSYISQTYQKFRGFFQAACDVPAPEEKFNVDEYSDMVTLSKPVIYISIEEIINTHSLVLEHKEAIAPDQSDLLHELLKDLGVVPDIESLLGEGTVDTNDLGKENSLSQHGKTEISLTLTNKFELLDGDDKDTKGLMTKTKKLIVDVVRIQPGETLTDILETPASATQEAEHAKLVERQVVQDSQTPEGLKSSQAMLEDRQLPLEQKKRKILRNLRTLEQAGLVNSKHKYQEVINDISKDIRYQRRYRQRRKAELVKLQQTLTALNSKTDFYQEQINYYDTYIKTCLDNLNRKNSRRSIKLDRKDEEKGSKKSKASSLKYTAAKLHEKGVILEIEGVQINQFKNVMFDICPCEEVGDFEIKAKFMGVEMEKVQLHFQDLLQLQYEGVAVMKMFDKAKVNVNLLIFLLNKKFYGK
Protein: Cytochrome c oxidase copper chaperone (Dopuin) (P81045)
Organism: Sus scrofa (Pig)
Function: Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Subcellular location: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q14061}. Cytoplasm {ECO:0000250|UniProtKB:Q14061}.
Interaction partners:
- HMA domain-containing protein.
- ATPase copper transporting alpha.
- Copper chaperone for superoxide dismutase
- Mitochondrial intermembrane space import and assembly protein 40
- Uncharacterized protein
- Cytochrome c oxidase assembly protein COX11
- Synthesis of cytochrome C oxidase 2
- P-type Cu
- Synthesis of cytochrome C oxidase 1
- NADH dehydrogenase flavoprotein 2, mitochondrial
Sequence:
PGLAAAIPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
Protein: FI01106p (Scratch, isoform A) (Scratch, isoform B) (Q9VZK2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPRCLIAKKWKAYPWLDRTEDTSNQQQQQEQSAPNSPRELEELHLKSRRSTLDDDEEIDVVGDKFLIKLEKQRTTADAAAAAATSSEAATSHSSNSSNMEASATTTTSKCWGPSSPTAGTTAPSPPPHSPEAATRVAGNVYNGYTRELSPLHYTAYLPRMESEITVIRAAATALVAARTSGNGSGDQHLAAYQTPPSSTTSSPSCSPSGAGDRYSPLSSGQTSSERKCFSSTGATLSLPPKKKDIYRPYSLDDKPAHGYRRRVPAEEDLHAAHAILDLSASTAFHPPTQPHQLQQQQQQQQQQHQHHHSQQQHLAPQQHHYLPLQQQQQQQAHHTHLPTLEAHAHLRSTSSIAELAAAASVVNEQRPASNASSASSNHMPSSPSSNSSSSSSQVQNENSNTTNTNPDGDGCLQDGEHSGASGASAKTVAYTYEAFFVSDGRSKRKHVADPAAAASGVPTPDQQKTKYTCSECGKQYATSSNLSRHKQTHRSLDSQSAKKCHTCGKAYVSMPALAMHLLTHKLSHSCGVCGKLFSRPWLLQGHLRSHTGEKPYGCAHCGKAFADRSNLRAHMQTHSVDKNFECKRCHKTFALKSYLNKHLESACLKDEEELMMSMSLSMHDSNSESGASMASSPPHEFLERVKLEGSGGATYAM
Protein: Ig gamma chain C region (P01870)
Organism: Oryctolagus cuniculus (Rabbit)
Interaction partners:
Sequence:
GQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTCSKPTCPPPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPITHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLTCMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYNKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRSPGK
Protein: Sex-determining transformer protein 1 (Hermaphrodization of XO animals protein 2) (P34708)
Organism: Caenorhabditis elegans
Function: Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes. Promotes female development. Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2. With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By similarity). In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons. Represses the expression of the transcription factor dmd-3 in hermaphrodites to govern the timing and extent of male tail tip morphogenesis. Plays a role in controlling the sex-specific differentiation of PHC sensory neurons and represses the development of male-specific morphological features.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11703944}. Nucleus {ECO:0000269|PubMed:11703944, ECO:0000269|PubMed:24682813}. Note=Localization with chromatin in the nucleus in part depends on normal function of wdr-5.1. {ECO:0000269|PubMed:24682813}.
Interaction partners:
- Sex-determining transformer protein 2
- Sex-determination protein fem-3
- Protein male abnormal 3
- Sex-determining protein fem-1
- Protein phosphatase fem-2
- Doublesex- and mab-3-related transcription factor dmd-3
- Anti-proliferative protein domain-containing protein
- Protein her-1
- XO lethal protein 1
- Protein maternal effect lethal 26
Sequence:
MMAPSTEDPDTVVEAQRRGSFSKKKNANGWNKVELVDQCAKQMGSEDKQPGGGDVKTENDPSKNGLGSATSNFIQSSVPPSHQTLSNPLQLSPPAEASVAQQSGASQVFPTFQAALGASSDELLQPNATSSSTSSSASTSSIVPVVKFTNQTAPNGSTVATSVGQNVRLTINGKRVGRPPGTFKRPQNNAANSSNSGNDSDMMGDHDLTCRWKSCNSSFQTLKALVDHVQESHVQSTEQEHHAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHTGEKPYKCEFADCEKAFSNASDRAKHQNRTHSNLKPYSCQIPQCTKSYTDPSSLRKHIKAVHGDDEYEKAKKSRPANYSNRRRPDHRLAPPTGAMSHPYLATPNSGASVVAHSSVHQQNFINMALAQHHHNAQRAQQLMAATGNVMPMMDPASAAAAAQAQAHHQAQAQMLQTHMMQQAQIQAAAQMQAQVQHQAAMQAHAMQQAQMVLQNNLLGAQSLLSPFSPLLPPSRAPNVMAMLQTPPTPTSVAPMFDIMTSRAPMAPVVSAPTAPAPLVPAPVPASPVFDELREQMREVEPLQQQQQQEPMDQDLQDIRVDGDSDDEDEEEPRTPSGALLLPRGGNNGDGGFGGSGSSRASSGSGTMELSAAPISQNGSRASGSGERGMRSFLIADILQLAADFQNERLLSDVLDLAIFDTRDVRSLHNIYQVYIRAHKAIPITRRPLDWNETHQLHNLYHDPRFNRAEHQDSPAIRDRDTRFWRTIAEANTMRQRQIEPVPLDDDDEGYFDEMVHRVQNGRLNEQFMEGFESDDDDGFEDEDDVPGLGIAVYRGRRRVRREALKQANLDIQEAETAGRNVGGFGDEEDRNNRGHDQDRSFLDHYYPPMVVVVETESPQIVRDQEMMRQFEEAKKNVETDEIKKRAEAMQFGTSSSHHHTKTLLIQRALFDKTSSVRRSLLQFITISVDQEELRQSCHATSAPQGAHVVHNVVDEFDSIMRAQEDSNNRILLSLDIPAPSAVTGVSGSITHADNSALQLQQEQPTSSFSSWFPEDDPIYALPPPPPPPAPPRRRRSADNKDDSENIPKKPRHQF
Protein: CHAT domain-containing protein (Q38CX9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNPSAQPWYPPAELVLGAPTAGLTAVRWQNDPYRSRIARCPPPPLCGDDDFISLRIESLVPVAGTKTDSPIPAALTAAAAAAVLPTAVQVPVTKGQPYRSSGVTFASVPTQAEARLQKRSQPVSRCQADLKPLWRSFATVSSLDSQGDSQEIEGATTEEKCCAARVRPARPKVPIPRPRSQLNADNAFAAARNLNKTVLAGSLDINPHTPASTPNDSSPDQTSETPAVSASGTDTTTTDGENNTCTTSSPTDVGASTGRNNTCSEDAEEPSCEVISVKSTAQEADVDEKPQCLANRAPPGPTASKKTRLKPKSEKWTIVGGKAGVALASVQAAVVPAKRPTASIASTKARESVSRHRTPDPKAKERVRSKQRQSQAQHREEVNKCSSKDDVIIEQKSKRQRDSRRPRECWTDEELLETLMSSTTISAQTGASSSGNSGDGAASFAIMGVPLVCVTRGEELLTSQSSSRSDARQRNALRLFIRSLAMFETSNAKTLLLQRALNGLPESCHHQCPSLVCAIMLEMSASCVDVEKSLQTCYKALRLSERHNLDTFEMLSRLGITRTLARVVDTMDARENLTRAALIAIDRLEKEALGWIVMQMGVTLEISGLFPDSLAWYEVAERLARSTGQQRLLCEVHCCQSIAYSAVGELERAQQAYEASRLLLSNIHRHCHQRPLQNYAQLKCQLGDMAGALQLQEEELAIAKELGDTHAASRCVGAIALTKRFLGRYDEAAENYMEEFSVHCSRDPRQAVESLTGAASCWRFGGHAQKAYDYCIRALTQARDCHDLTTIAKALAELAETELSMDRLDEAQEHLREALTAVFRVDDAEQKQYLVKAALCEVEWRCCSALGQVYARRGQAFEAMQCADRCHVPNTVHMGRLLLRRQRCAGAIHDATNPELVSRQSVERVLKHPTLKGWNVVCYSLPWAEKLDFMVYVVMLDADSGELKCVAHPLVMSDELVAFFSGPNALWDLLDAPMFTDTGDRMYGDTPLWPQLYSKVAFDFQQNPSNAECLVSLRTDPHYCLRLLYDNFVRPLEADVAGAEGLMFVADGVFSRIPFHALHDGKKYLAERFCTSTCCSMALLCTHAVEDESIKAAVTPPAKATDGGSEESMGGMIPKRYTIVDDASHKVVLMDSFVEEMVAKSNDSSNPVGVCVRHWVVDEKQPVISCVANEQQLIDAASSSDNSKDGNGDISAEAAGNDDPDVSATKHLLSCLRRRGNVTSVRNSLYRAVHENPEGVLELRLRVVPEVKEDYCGTFVGASCDVSASHASEVASSWELRGYALVLCSGIGTYGGLSMHETGVPVYRALQYAGARCMLLAAGSRVPPYVKVPAAAADAALNGRSVAAALREAYVRAIAADVPLEDWCGFALVGLPIS
Protein: Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3) (P62509)
Organism: Mus musculus (Mouse)
Function: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Nuclear receptor corepressor 2
- Nuclear receptor coactivator 1
- Nuclear receptor-interacting protein 1
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Steroid hormone receptor ERR1
Sequence:
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
Protein: CNMamide, isoform D (M9PE91)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSALSAPTTCGCSPVHWAIVIVLLSVAIGPGDAMARPARNTQLLFSELLGGGNDDNNYYGDQLKYQQQQQQQQEQKQQRVPAFARKWPSLRDLLLTVDYDDFGVTQESEEQVAPSSRLLARLHRLGDNGGGEELRYNVVNELTNMPSKKVMPGHPLKDHNTKKNVQYMSPCHFKICNMGRKRNAGFNSY