wanglab/gogpt-training-data huggingface dataset:
Protein: UBX domain-containing protein 10 (O74498)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in protein degradation through the ubiquitin/proteasome pathway.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}.
Interaction partners:
- DSC E3 ubiquitin ligase complex subunit 2
- Cell division cycle protein 48
- Ubiquitin fusion degradation protein 1
- DSC E3 ubiquitin ligase complex subunit 1
- Nuclear protein localization protein 4
- UBX domain-containing protein 2
- UBX domain-containing protein 3
- Protein OS-9 homolog
- ERAD-associated E3 ubiquitin-protein ligase hrd1
- Ubiquitin homeostasis protein lub1
Sequence:
MSGSRKQEAIDELRNSLDVPADTAQSVLESFNWDVQEAIESLTGESSRVDRNSKLGLSFGVFQSVFSLLFSGLHKLWMILSRVPLISTFIPIFGTTKRVLSPADTANKLVQNLEEQYGTEHIDFFTDGGYMEALTRIKRNYGVALLFFTSSKNDDSETFSRSVLMNQELKEFLNRRNILCWTGDVCEDEAFRGSRQFHCTKFPSAVLVMYSPQLSELVVAAQLHGCLDSSSIITNLTNALAKHLPSLERFRSEREAREAARELRRQQDNAYQASLARDRERQAFARAEEERLAKEKEEREIVQKKKKQYRAWLASNLPPEPSSEDEPARLSIRFPDGSRAVRRFKKDDTVESVYNYVDYMLFEKEEPEEFGRATSSSNPVTPPSDYKHDFHFQLYSSLPRALLKPSVAISTNKAIFPNGTVVVELDD
Protein: Protein phosphatase 1H (EC 3.1.3.16) (Q3UYC0)
Organism: Mus musculus (Mouse)
Function: Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9ULR3}. Cytoplasm {ECO:0000250|UniProtKB:Q9ULR3}.
Interaction partners:
- RILP-like protein 2
- RILP-like protein 1
Sequence:
MLTRVKSAVANFMGGIMAGSSGSEHGGSGCGGSDLPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKAGTITSTPNRNSKRRSSLPNGEGLQLKENSESEGISCHYWSLFDGHAGSGAAVVASRLLQHHITQQLQDIVEILKNSAILPPTCLGEEPESTPAHGRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSAYNISGGCTALIVVCLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDDDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRVYDLSRYEHGADDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKLS
Protein: Acetyl-coenzyme A transporter 1 isoform X1 (Solute carrier family 33 member 1) (B8JLW5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
- Beta-1,4 N-acetylgalactosaminyltransferase.
- Beta-1,4 N-acetylgalactosaminyltransferase
- Alpha-2,8-sialyltransferase 8E
- lysophospholipase
- Phosphopantothenoylcysteine synthetase.
- Magnesium transporter NIPA1
- Atlastin-1
- Vacuolar protein sorting 37A.
- Spastin
Sequence:
MELSESLTHKNGRQRKPVLLNMGERESKLEVGGDEEALLPNSDRADGRTQTHKGIKGELGNVSLLLFLYVLQGIPLGLAGSIPLIMQSKNVSYKDQAYFSFVFWPFSLKLFWAPLVDSVYLKQFGRRKSWLVPTQYLLGLFMLYLSLTVDSMLQTDGQKGPDVITLTAVFFLLAFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFEPQERGIVTLSDFLFFWGIVFMVSTTLVAVLKKENGKPHPAKKKPKEETQGVKETYKLLFSIIKMPTVFTFCALLLTAKVGFSAADAVTGLKLVEAGVPKEQLALLAVPMVPLQILLPLVISKYTAGPRPLDIFYKAFPFRLLIGLEYALLVWWTPSVRQEEGFPVYYYAVVLLSYAVHQVALYSMYVACMAFHAKVSDPVIGGTYMTLLNTVTNLGGNWPSTLALWLVDPLTSKECDGAPGQTCSSIEEAGLCVREGGSCVTSLDGYYVESVVCVLIGLCWWIFFGKRMKRLQEESPSAWHCRVAK
Protein: Leucine-rich repeat transmembrane neuronal protein 1 (Q86UE6)
Organism: Homo sapiens (Human)
Function: Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Neurexin-1
- Catenin alpha-2
- Neurexin-2
- Trafficking protein particle complex subunit 10
- Disks large homolog 4
- Neurexin-3
- Neuroligin-1
Sequence:
MDFLLLGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHAENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV
Protein: RING-H2 finger protein ATL73 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ATL73) (Q9FLC6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Ubiquitin domain-containing protein DSK2a
- NAC
Sequence:
MARFLLATQATPTISATDANPRTLGDSVSNNKNIASMDTHMVIILAALLCALICALGINSVLRCVLRCTRRFTPNEDPVDTNANVAKGIKKRALKVIPVDSYSPELKMKATECLICLGDFVEGETVRVLPKCNHGFHVKCIDTWLLSHSSCPTCRQSLLEHQTPANGSRRGDDVAT
Protein: K Homology domain-containing protein (Q9GRY9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MAEEFTEDSKTQQGVKRTQDASDGPANKKAHFGGEEEGGDHLSIKILIPSNAVGAIIGKGGEAMRNLKNDNNCRVQMSKNSETYPGTSERICLVKGRLNNIMAVIESIQDKIREKCADQGGSDAFDHKNTSRGAEIKIVMPNTSAGMVIGKSGANIKDIREQFGCQIQVYPKAGSVEAKTSLERVVTVAHDEASALLQAASRVLEKVASDPHHASEINKEDFGKGSGPSGSANSGPSGGGGGGGGGGQSNNNSSFSSVPAFNGGGGGGGGMNVGAAGFGGGGGQGYGGPQFGGQGGPQFGNGNNKYPMSGLGNNELLSFLDNLQSTLRTSGFNEQSVSEVMQAMQVLAKYNIMGLGLGLGVAAMAQMRTGQESQGMSANHGSAGFGDGYGQGGVQGGPQGPQGGGGDQSYWRR
Protein: NADH-specific methylglyoxal reductase (EC 1.1.1.-) (AKR11B2) (P77256)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It is not known if this activity has physiological significance. Cannot use NADPH as a cosubstrate. Seems to play some role in intestinal colonization.
Interaction partners:
- NADPH-dependent aldehyde reductase YqhD
- Uncharacterized sugar kinase YdjH
- Methylglyoxal synthase
- Glycerol dehydrogenase
- Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjJ
- Uncharacterized protein YdjI
- Putative metabolite transport protein YdjK
- Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjL
- Inner membrane metabolite transport protein YdjE
- Uncharacterized HTH-type transcriptional regulator YdjF
Sequence:
MKKIPLGTTDITLSRMGLGTWAIGGGPAWNGDLDRQICIDTILEAHRCGINLIDTAPGYNFGNSEVIVGQALKKLPREQVVVETKCGIVWERKGSLFNKVGDRQLYKNLSPESIREEVAASLQRLGIDYIDIYMTHWQSVPPFFTPIAETVAVLNELKSEGKIRAIGAANVDADHIREYLQYGELDIIQAKYSILDRAMENELLPLCRDNGIVVQVYSPLEQGLLTGTITRDYVPGGARANKVWFQRENMLKVIDMLEQWQPLCARYQCTIPTLALAWILKQSDLISILSGATAPEQVRENVAALNINLSDADATLMREMAEALER
Protein: Uncharacterized protein YgeH (P76639)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YgeG
- Uncharacterized protein YgeI
- Uncharacterized protein YqeI
- Uncharacterized protein YqeK
Sequence:
MDLENKFSYHFLEGLTLTEDGILTQGNEQVYIPQKELGVLIVLLESAGHVVLKDMIIESVWKNIIVSDESLTRCIYSLRCIFEKIGYDRCIETIYRKGYRFSGQVFKTKINEDNTSDYSIAIFPFTTSLNTLDPLILNQELVQIISNKKIDGLYTYPMAATNFCNDHISQNSFLSRFKPDYFVTGRINQNNAVNTLYIELIDAKNLFLIASNHLPVDELHNTSQFIIDNILQTVHKPERSVRLAKQDQGYKNHYLSDEMLAGKKELYDFTPESIYRAMTIFDRLQNKSDIQTLKTECYCLLAECHMSLALHGKSELELAAQKALELLDYVSDITTVDGKILAIMGLITGLSGQAKVSHILFEQAKIHSTDIASLYYYRALVHFHNEKIEEARICIDKSLQLEPRRRKAVVIKECVDMYVPNPLKNNIKLYYKETESESHRVIIDNILKLKQLTRICMR
Protein: Major capsid protein (Gene product 23) (Major head protein) (gp23) [Cleaved into: Mature major capsid protein (gp23*)] (P04535)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Major capsid protein that self-associates to form hexamers, building most of the capsid in association with pentons made of the capsid vertex protein and one dodecamer of the portal protein. The major capsid protein self-associates to form 160 hexamers, building most of the T=13 laevo capsid. Folding of major capsid protein requires the assistance of two chaperones, the host chaperone groL acting with the phage encoded gp23-specific chaperone, gp31. The capsid also contains two nonessential outer capsid proteins, Hoc and Soc, which decorate the capsid surface. Through binding to adjacent gp23 subunits, Soc reinforces the capsid structure.
Subcellular location: [Major capsid protein]: Virion. Note=Part of the capsid icosahedric shell of the immature virion. The capsid is made of 930 copies arranged as 160 hexamers. {ECO:0000255|HAMAP-Rule:MF_04117, ECO:0000269|PubMed:11162794, ECO:0000269|PubMed:6406677}.; SUBCELLULAR LOCATION: [Mature major capsid protein]: Virion. Note=Part of the icosahedric capsid shell of the mature virion. {ECO:0000255|HAMAP-Rule:MF_04117, ECO:0000269|PubMed:11162794, ECO:0000269|PubMed:15071181}.
Interaction partners:
Sequence:
MTIKTKAELLNKWKPLLEGEGLPEIANSKQAIIAKIFENQEKDFQTAPEYKDEKIAQAFGSFLTEAEIGGDHGYNATNIAAGQTSGAVTQIGPAVMGMVRRAIPNLIAFDICGVQPMNSPTGQVFALRAVYGKDPVAAGAKEAFHPMYGPDAMFSGQGAAKKFPALAASTQTTVGDIYTHFFQETGTVYLQASVQVTIDAGATDAAKLDAEIKKQMEAGALVEIAEGMATSIAELQEGFNGSTDNPWNEMGFRIDKQVIEAKSRQLKAAYSIELAQDLRAVHGMDADAELSGILATEIMLEINREVVDWINYSAQVGKSGMTLTPGSKAGVFDFQDPIDIRGARWAGESFKALLFQIDKEAVEIARQTGRGEGNFIIASRNVVNVLASVDTGISYAAQGLATGFSTDTTKSVFAGVLGGKYRVYIDQYAKQDYFTVGYKGPNEMDAGIYYAPYVALTPLRGSDPKNFQPVMGFKTRYGIGINPFAESAAQAPASRIQSGMPSILNSLGKNAYFRRVYVKGI
Protein: Metabotropic glutamate receptor-like protein N (Q54QG7)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MKLYTHKINRIVDGYLDNLNKFGLNYMFEQDLIKITLDLGIPNNNIKFYNLNNSNSNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNSNNINNKNDILYNIIIEEKIDLIIFYKSIFSENANNISKTFNNLTTIIINDNIISNTNNNNNNNNKFYEINYPFKISTLLSGYISGLISETNIIGYLKTNKIQDQTLLDTFYFGARLSNPMVKLMFYTIDYDFKNASNNNFPFQEIIELSVSSLLKNGVDLISSSFENNEYLTFCNILLKQNIKIIGSNGFLISPPLNKDHVLFNSVYNLTLYILPIISNLINNTNTNNNNNTNNNESTNSQFNINLIFNPSISNLIINNINSNLSMIENQILNDTNIILTNQLNNESIIDLGIISGYILFKPISKTIEYGITIVSSILIGALIIIQICIIKYKNKPSFKSASPTFLIFIVIGGIFVYIGVIIWVSGVNVFTCNAKFWLISLGLTTMIGGIVVKNFRIWLIFDNPKLYHIKITNLQLLPWVLGMFLLNVFLLSLITGLGKLTPFKVFPNDEKFSSYEIQCEMMDGGLIALYFLLGYFAIIVMIGIFVSWKIRIVDIEEFNESKSVAYSLYSIVFCLLIIAPLTISKTGHNTEILCSGFIFIVAAIITIMFIPKFWALKIYGAEGSNEIFRQSSSSTSKRKNKSSTTNDPTNLDSISKKSSKNAPKRVNLFLYDFTDDDEESKQSSSSSKGDTIECMDVFTFIESVQPNSEAANEMTYNDDPTYTEPSEQPTYTESSEQPNPTPRTLTATPRTNDLTTPRTNDLTTPRTNDLITPRTNDLSTPRTNDLNTPRTDGILTPRSINSLATPRVEEPMSPRQYHNMMITLSPILEEENIVVVEKDEVIENSDSESESSDSNSDSIIQ
Protein: Nucleophosmin (A0A0S2Z491)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
Protein: Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) (Q13523)
Organism: Homo sapiens (Human)
Function: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
Subcellular location: Nucleus {ECO:0000269|PubMed:12077342}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17998396}. Note=Located throughout the nucleus, excluding the nucleolus but enriched in multiple speckles. {ECO:0000269|PubMed:12077342}.
Interaction partners:
- Pre-mRNA-processing factor 6
- U4/U6 small nuclear ribonucleoprotein Prp31
- U4/U6 small nuclear ribonucleoprotein Prp4
- Pre-mRNA-processing-splicing factor 8
- 116 kDa U5 small nuclear ribonucleoprotein component
- Pinin
- RNA-binding protein 25
- U4/U6.U5 tri-snRNP-associated protein 1
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Probable ATP-dependent RNA helicase DDX23
Sequence:
MAAAETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI
Protein: CBWD5 protein (Zn regulated GTPase metalloprotein activator 1E) (Q6NVZ8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVTSMFWVDAELGSDIYLDGIITIVDSKYGLKVKYH
Protein: Potassium channel, subfamily K, member 13 (K2P13.1b) (Tandem pore domain halothane-inhibited potassium channel) (Q5VSE6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9HB14}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Si:dkey-21h14.12.
Sequence:
MACRSGCCCNSIGSFNEDNARFLMLALLIIIYLLCGAAVFSALEQPKEKLAKERWAQRIEQFTNKYNLSQDDLKNFLRNYEEANVAGIRVDATRARWDFAGAFYFVGTVVSTIGFGMTTPVTIAGKIFLIFYGLIGCAATILFFNLFLERVITVIAFVLKFCHERRESRKAGPTQNCRRPSTDNRDRRTDSLAGWKPSVYCVMLILGVAAILVSCCASAMYSAAEGWDYLDALYFCFVAFSTIGFGDMVSNQREIYEAQVAYRVGNFLFILTGVCCIYSLFNVISIVIKQVLNWLLRRLETPCHCPGRGNRHPRRNAVVPGHMRSRRENSIETDAVNDSEADGRRMSGEMISMKDFLAANKVNLAIMQKQLSEMANGHPRQSGSSSRHNEFSGGVGALGIMNNRLAETSVDR
Protein: Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) (Q9BUQ8)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9409622}. Chromosome {ECO:0000269|PubMed:28076779}. Note=During transcription, accumulates at chromatin loci where unscheduled R-loops form and colocalizes with paused 'Ser-5'-phosphorylated POLR2A/RNA polymerase II and kinase SRPK2. {ECO:0000269|PubMed:28076779}.
Interaction partners:
- Pre-mRNA-processing-splicing factor 8
- U4/U6 small nuclear ribonucleoprotein Prp3
- Small nuclear ribonucleoprotein Sm D2
- 116 kDa U5 small nuclear ribonucleoprotein component
- Thioredoxin-like protein 4A
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Pre-mRNA-processing factor 6
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein E
- U5 small nuclear ribonucleoprotein 40 kDa protein
Sequence:
MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA
Protein: LRRGT00016 (Lon peptidase 2, peroxisomal) (Q6TXI3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSSVNPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDSQDLPPLHRPICVDCFAPCSLGSRASLDCTVTVDIEHLKCVCSNTSFNTGMHVLLRAVQMMEAWLMEIQRRAKTQLGLLRVESGIWSAGNEELAATNKRTEPLRLKPLLCWDNGSGERAGESAVIKNKPASLRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNTCKTREELGELSEQFYRYSVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHIPGALEDEEEEEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQLTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVAEGQHKEAKLDRSDVADGEEPAASILGLRAALESRQTTLIPVHEEASDSRGSGCAPLVNLTTNGSVLAVPEMTIMSLFQKVLRTNLLCSAPLTLPIFPDKSPI
Protein: PrcB (B8YNY4)
Organism: Treponema denticola
Interaction partners:
Sequence:
MIYLSTMRFCVILLFICCVTFLGCKTLPKQPAGEFHSVPDDKVPTVPDKGADGSPGSSFKNPEILSSPSESMQAGYEILIQGNNFKTGLPSIVKSQEDLQTLYSVLYGNSLKAPVIDFSKKAVVIAAAGPFNTGGYSIVPVSAIKTGKIINLVFEVKSPGPKDMVTQAFTRPYVIVSVDAEPDTEIFIEINGDAKNDKLDF
Protein: Dementin, isoform G (B7Z0W3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTDFLGPQQGGGGGGGGGGGGGGGGGSAGTGSGLEDSRLSGNEDYYSSFVSDEFDSSKKVHRRCHERSSSVQAIDRLNTKIQCTKESIRQEQTARDDNVNEYLKLAASADKQQLQRIKAVFEKKNQKSAHNISQLQKKLDNYTKRAKDLQNHQFQTKSQHRQPREVLRDVGQGLRNVGGNIRDGITGFSGSVMSKPREFAHLIKNKFGSADNINQMSEAELQGMQSANADVLGSERLQQVPGAGTSTGSGGGGQNNNTGGAGSGTGKFNSDNGSECSSVTSESIPGGSGKSQSGASQYHIVLKTLLTELAERKAENEKLKERIERLETGQKEFNNLTATLESERYRAEGLEEQINDLTELHQNEIENLKQTIADMEEKVQYQSDERLRDVNEVLENCQTRISKMEHMSQQQYVTVEGIDNSNARALVVKLINVVLTILQVVLLLVATAAGIIMPFLKTRVRVLTTFLSICFVIFVIRQWPDVQDIGSGLVRHLKQSLVVK
Protein: F2R like trypsin receptor 1 (Proteinase-activated receptor 2) (F1S2H4)
Organism: Sus scrofa (Pig)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Prothrombin
Sequence:
MRSLSAGWLLGGVILLAASVSCNRTVLGTSRPSKGRSLIGKADNTPPITGKGATVEPGFSVDEFSASVLTGKLTTVFLPVVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWVYGESLCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMVHPRKKANVAIGVSLGIWLLILLVTIPLYVVKQTLYIPALHITTCHDVLPEEVLVGDMFNYFLSLAIGVFLFPAFLTAAAYVLMIRTLRSSAMDENSGKKRQRAIKLIITVLAMYLICFTPSNLLLVVHYFLIKTWGQSHVYALYIVALCLSTLNSCIDPFVYYFISKDFRDHAKNALLCRSVRTVKQMQVSLSSTKFSRKSSSYSSSSTSVKTSY
Protein: Transcription factor TCP24 (Q9C758)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164). In association with ABAP1, exerts a negative role in cell proliferation in leaves, possibly by inhibiting mitotic DNA replication. Participates in ovule develpment.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- ARMADILLO BTB ARABIDOPSIS PROTEIN 1
- Transcription factor TCP14
- Transcription factor TCP15
- Transcription factor TCP19
- Transcription factor TCP20
- Transcription factor TCP16
- Transcription factor TCP21
- Protein SPEAR3
- CDT1-like protein b
- Transcription factor TCP22
Sequence:
MEVDEDIELQKHQEQQSRKLQRFSEDNTGLMRNWNNPSSRIIRVSRASGGKDRHSKVLTSKGLRDRRIRLSVATAIQFYDLQDRLGFDQPSKAVEWLINAASDSITDLPLLNTNFDHLDQNQNQTKSACSSGTSESSLLSLSRTEIRGKARERARERTAKDRDKDLQNAHSSFTQLLTGGFDQQPSNRNWTGGSDCFNPVQLQIPNSSSQEPMNHPFSFVPDYNFGISSSSSAINGGYSSRGTLQSNSQSLFLNNNNNITQRSSISSSSSSSSPMDSQSISFFMATPPPLDHHNHQLPETFDGRLYLYYGEGNRSSDDKAKERR
Protein: FAD-dependent monooxygenase vrtH (EC 1.-.-.-) (Viridicatumtoxin synthesis protein H) (D7PHZ9)
Organism: Penicillium aethiopicum
Function: FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system. The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA. The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB. The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone. The cyclization of the last ring could be mediated by the lactamase-like protein vrtG. The proposed post-PKS tailoring steps are an hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF. VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin. Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin.
Interaction partners:
Sequence:
MQRANHTRPVLIIGAGLSGLAIGRLLTNNGIANIVFEASPPERSQGFAISLHDWGYSLLLEALGGLSLRAMTKAVAPDRFIGGTGWVDLIMRDNTTGKVLVEPDVDARPAVIRANRNSLRAWMADCGDDELDVRYGHRLKSISGSVGNVQAVFENGAEYRGSIVIAADGVHSAVRSQVLPHIVPEVLPVVVYHGEFQVSHDEYDRCVRPVIGTANILAGVGDGFNTPITVCNITKTQVHLDWSYSRPARGENDPLFSTKTPEDQTRDLPQALLEELASRQLAEPWAKYINPETIQQHSVFRWISRCVYMPTADALHAAQAGVVFIGDAWHAMPIFGGEGGNHALVDSVELAAAMVKEANVERAVAVYYEGAARRCQEAVRRSRSRFYVLHRPMAEWRDIAEKRRAKAALEQKH
Protein: 3-dehydroquinate dehydratase (3-dehydroquinase) (DHQD) (EC 4.2.1.10) (Type I DHQase) (Type I dehydroquinase) (DHQ1) (P58687)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsilon-amino group of a Lys-170 at the active site.
Interaction partners:
- Quinate/shikimate dehydrogenase
- 3-dehydroquinate synthase
- Shikimate dehydrogenase
- Chorismate synthase
- Shikimate
- Shikimate kinase 1
- Periplasmic serine endoprotease DegP
- MFS family transport protein
- Isochorismate synthase EntC
- Isochorismate synthase MenF
Sequence:
MKTVTVRDLVVGEGAPKIIVSLMGKTITDVKSEALAYREADFDILEWRVDHFANVTTAESVLEAAGAIREIITDKPLLFTFRSAKEGGEQALTTGQYIDLNRAAVDSGLVDMIDLELFTGDDEVKATVGYAHQHNVAVIMSNHDFHKTPAAEEIVQRLRKMQELGADIPKIAVMPQTKADVLTLLTATVEMQERYADRPIITMSMSKTGVISRLAGEVFGSAATFGAVKKASAPGQISVADLRTVLTILHQA
Protein: Annexin D3 (AnnAt3) (Q9SE45)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- non-specific serine/threonine protein kinase
- Probable mediator of RNA polymerase II transcription subunit 26b
Sequence:
MATIRVPNEVPSPAQDSETLKQAIRGWGTDEKAIIRVLGQRDQSQRRKIRESFREIYGKDLIDVLSSELSGDFMKAVVSWTYDPAERDARLVNKILNKEKKKKSLENLKVIVEISCTTSPNHLIAVRKAYCSLFDSSLEEHIASSLPFPLAKLLVTLASTFRYDKDRTDAEVATIEAAMLREAIEKKQLDHDHVLYILGTRSIYQLRETFVAYKKNYGVTIDKDVDGCPGDADLRSLLKVAIFCIDTPEKHFAKVVRDSIEGFGTDEDSLTRAIVTRAEIDLMKVRGEYFNMYNTSMDNAITGDISGDYKDFIITLLGSKI
Protein: COMM domain-containing protein 5 (Q76NP9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- COMM domain-containing protein 10 homolog Vlet
- LD28404p
- Coiled-coil domain-containing protein 22 homolog
- IP19808p
- Coiled-coil domain-containing protein 93
Sequence:
MSSTFRYNLLRSVKPYTSFTPQLTKSMLRVLIQVSVHYIESKKSSSEVLSLALNKLTNGGHEIPPNFCELFTMVFLTMQIFLRYPKGVVKHHELRKCLMDDLNLTEEYVEDICKVLLNHRDVLSKNFSDTKMDRVKMSKLQWRINISLSLNTVQIDKPTIVLHFKLQNKEYRTLELPLSMFQQVRYNIALLLNELQSLQSRLALK