wanglab/gogpt-training-data huggingface dataset:
Protein: Calaxin (EF-hand calcium-binding domain-containing protein 1) (Q1LWZ0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Regulates ciliary and flagellar motility and is required for cilia-driven determination of body laterality.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q96M63}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9HAE3}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9HAE3}.
Interaction partners:
- Armadillo repeat-containing 3
- Armadillo repeat containing 4
- Outer dynein arm-docking complex subunit 4
- EF-hand domain-containing family member C2
- IQ motif and ubiquitin domain-containing
- Piercer of microtubule wall 2 protein
- Coiled-coil domain containing 151
- Coiled-coil domain-containing 96
- Coiled-coil domain-containing 114.
- Ring finger and SPRY domain-containing 1.
Sequence:
MNRKLIQNLAETLCRQVKHFNKTETECLIRLFNSLLGEQAERKTTIGVDRAKFRNILHHTFGMTDDMMTDRVCRVIDKDNDGYLSVKEWVEALSVFLRGTLDEKMKYCFEVYDLNGDGYISREEMFQMLKDSLIRQPTEEDPDEGIKDIVEIALKKMDYDHDGRVSYADFEKTVMDENLLLEAFGNCLPDAKSVLAFEQQAFQKHEHCKE
Protein: DNA replication licensing factor mcm-6 (EC 3.6.4.12) (P34647)
Organism: Caenorhabditis elegans
Function: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- CDT1 Geminin-binding domain-containing protein
- Protein MCM10 homolog
- DNA replication licensing factor mcm-4
- DNA replication licensing factor MCM2
- Cell division control protein
- DNA replication licensing factor MCM3
- DNA replication licensing factor mcm-5
- DNA replication licensing factor MCM7
- Minichromosome loss protein Mcl1 middle region domain-containing protein
- Origin recognition complex subunit 5 C-terminal domain-containing protein
Sequence:
MDNIIGGQAQQVEDTDGTRVQNEFSKFLKSFKDQKNEFIYKSAMKELVQPEKNTIFINMQHLYKFSNNLATTIELQYYRVYPFMCEALHLATLDACDESERQQMFKKQLYVSLFNLDAKTKVRELSADKVGGLVRIAGQIVRTHPVHPELSRACFVCEDCGVTTRDVQQQFRYTQPTKCANPQCMNRTRFSLDVNSSTFVDFQKIRIQETQAELPRGSIPRTVDVIVRGEMVETVQPGDKCDIVGTLIVIPDIAQLSTPGLRAETSNQNRGRATDKSEGITGLKALGVRDLTYKMAFLACHIQQTESLVGGDASGAVEETDYLDLWSKMSTEDRATLKKMSDDKKIEKNIVDSLFPNIYGNHEVKLGVLLMLLGGVAKKSRDEGTSLRGDINVCLVGDPSTAKSQVLKAVEEFSPRAIYTSGKASSAAGLTAAVVKDEESFEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARASILAAANPVNGRYDRSRPLKYNVQMSAPIMSRFDLFFVLVDECNEVTDYAIARRILDNHRAISEHTERDSVYKIDDIKKYIAFARCFKPKISDKAAETLVREYKKLRMSDSNNAATSSWRITVRQLESLVRLSEALARLHCGKEVLVEHVEKAAELLNKSIVRVEQPDIALDDDDFDNNIMVVEADKENQRGDDSMDHDGEKENAPKIDIAKLKISFKEYKQLSDVLVLHMRSDEDNQGEDEYDGVKQSALVEWYLSTIEADLETEEDFNVQKTICERVIHRLIHQDHVLLEVEQGEDPTLCVHPNYVIADE
Protein: L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (P00337)
Organism: Gallus gallus (Chicken)
Function: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Pyruvate kinase PKM
- Aspartate aminotransferase, mitochondrial
- Lipoyl-binding domain-containing protein.
- Aspartate aminotransferase, cytoplasmic
- Pyruvate dehydrogenase E1 component subunit alpha
- Pyruvate dehydrogenase E1 component subunit beta
- Malic enzyme.
- Malic enzyme
- Transketolase
- 2-oxoisovalerate dehydrogenase subunit alpha
Sequence:
MATLKEKLITPVAAGSTVPSNKITVVGVGQVGMACAISILGKGLCDELALVDVLEDKLKGEMMDLQHGSLFLQTHKIVADKDYAVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPNCTILVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDTARFRYLMAERLGIHPTSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPAMGTDKDSENWKEVHKQVVESAYEVIRLKGYTNWAIGLSVAELCETMLKNLYRVHSVSTLVKGTYGIENDVFLSLPCVLSASGLTSVINQKLKDDEVAQLKKSADTLWSIQKDLKDL
Protein: Signal transducer and activator of transcription (O13133)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
Sequence:
MAQWNQLQQLETRYLEQLYHLYSDSFPMELRQFLAPWIESQDWAYAANKESHATLVFHNLLGEIDQQYSRFLQENNVLYQHNLRRIKQHLQSKYLEKPMEIARIVARCLWEEQRLLQTATTAAQDGTASHPSGTVVTEKQQILEHNLQDIRKRVQDMEQKMKMLENLQDDFDFHYKTLKSQGELSQDMNGNSQAAATRQKMSQLEQMLSALDQLRRQIVTEMAGLLSAMDFVQKNLTDDELADWKRRQQIACIGGPPKICLDRLETWITSLGEIQLQIRQQIKKLEELQQKVSYKGDPIIQHRPALEEKIVDLFRNLMKSAFVVERQRCMPMHPDRPLVIKTGVQFTNKVRLLVKFPELNYQLKIKVIIDKESGDVAAIRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRTNSDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNHPKNVNFFTKPPVGTWDQVAEVLSWQFSSTTKRGLTIEQLTTLAEKLLGPCVNYSGCQITWAKFCKENMVGKGFSFWVWLDNIIDLVKKYILALGNEGYILGFISKERERAILSPKPPVTFLLRFIESSKEGGVTFTWVEKDISGKTQIHSVEPYTKQQLNSISFAKIIMGYKIMDATNILVSPLVYLFPKIPKEDAFGNYCRPEAAPKAELGNPCITIQPYLKTNFICVTPTNSGNTSDLFPMSPRTLNSLMHNKAEANPGPLDSLTLDMELSSDVASPM
Protein: Transmembrane protein 198 (Q66K66)
Organism: Homo sapiens (Human)
Function: Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Largely located to vesicle-like structures. {ECO:0000250}.
Interaction partners:
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
Sequence:
MPGTVATLRFQLLPPEPDDAFWGAPCEQPLERRYQALPALVCIMCCLFGVVYCFFGYRCFKAVLFLTGLLFGSVVIFLLCYRERVLETQLSAGASAGIALGIGLLCGLVAMLVRSVGLFLVGLLLGLLLAAAALLGSAPYYQPGSVWGPLGLLLGGGLLCALLTLRWPRPLTTLATAVTGAALIATAADYFAELLLLGRYVVERLRAAPVPPLCWRSWALLALWPLLSLMGVLVQWRVTAEGDSHTEVVISRQRRRVQLMRIRQQEDRKEKRRKKRPPRAPLRGPRAPPRPGPPDPAYRRRPVPIKRFNGDVLSPSYIQSFRDRQTGSSLSSFMASPTDADYEYGSRGPLTACSGPPVRV
Protein: Inositolphosphotransferase 1 (EC 2.7.1.228) (Mannosyl diphosphorylinositol ceramide synthase) (P38954)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the addition of a phosphorylinositol group onto mannosyl phosphorylinositol ceramide (MIPC) to form mannosyl diphosphorylinositol ceramide (M(IP)2C), the major sphingolipid in membranes of S.cerevisiae.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:14583628}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mannosyl phosphorylinositol ceramide synthase SUR1
- Beta-glucan synthesis-associated protein SKN1
- Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2
- Transcription factor PDR3
- Transcription factor PDR1
- Oligomycin resistance ATP-dependent permease YOR1
- ATP-dependent permease PDR10
- Pleiotropic ABC efflux transporter of multiple drugs
- Mannosyl phosphorylinositol ceramide synthase CSH1
- Sphingolipid C4-hydroxylase SUR2
Sequence:
MNVIFSLASFVKNMYNASLNQRNLISLPFNFMLNFAPVFIWLSIFKRAGLIPIRLRPDIHSKFAFFADQFLFGDYWHELTVQLPDNTSKLFFWSFISSSAFLLVFLICIPFAIWYYIYYIKHVNYNLLEWFANIFHYPCKRKQRPIQKRFRTIFIPFALPLFTFVILNIDHFFAYQSDANFTKTKDLLAWFSYVILHLTAPILTAVYLYVFQPPGTLKCFSFALGLQNIAGVLTHLLVPMASPWFTHLYGIDDTEHVNYTQEGFAAGLIRVDSHLGTHLNTKGFHMSPIVFGAVPSLHSAIAFQCFLFLVSRSTSLKHRFSNAGGFTMHNNDSSTFKLSEEDSEDEGDNSIPPTIGPNDLEMEPLGTVEPVDISNERSSSPSSSFTVSSNERSTGGGDGSIINSNGNKKPLQFVHLYDEDTNFTNKWIFKIVNDGFIPKFWAILYIILQWWATMYLDHHYRFDLFVGVLYAMTSFIIINWFVLQPKVLKKWIHIRLGDKVDTRNEARTFGMRVFCGTKMEWFFDPLA
Protein: Probable protein phosphatase 2C 58 (AtPP2C58) (EC 3.1.3.16) (Q93YW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F-box only protein 7
- Filament-like plant protein 6
- glucan endo-1,3-beta-D-glucosidase
- Probable serine/threonine-protein kinase PBL16
- Calcium-binding EF-hand family protein
- E3 ubiquitin-protein ligase APD1
- Glucan endo-1,3-beta-glucosidase 7
Sequence:
MAGSNILHKIKLKAGFCGSAPDMGRGKSKMWKNITHGFHCVKGKSSHPMEDYVVSEFKKLEGHELGLFAIFDGHLGHDVAKYLQTNLFDNILKEKDFWTDTENAIRNAYRSTDAVILQQSLKLGKGGSTAVTGILIDGKKLVVANVGDSRAVMSKNGVAHQLSVDHEPSKEKKEIESRGGFVSNIPGDVPRVDGQLAVARAFGDKSLKLHLSSEPDITHQTIDDHTEFILFASDGIWKVLSNQEAVDAIKSIKDPHAAAKHLIEEAISRKSKDDISCIVVKFH
Protein: Cyclin B2 (H1UBN3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALLRRPTVSSDLENIDTGVNSKVKSHVTIRRTVLEEIGNRVTTRAAQVAKKAQNTKVPVQPTKTTNVNKQLKPTASVKPVQMEKLAPKGPSPTPEDVSMKEENLCQAFSDALLCKIEDIDNEDWENPQLCSDYVKDIYQYLRQLEVLQSINPHFLDGRDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQVQPVSRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQHTLAKYLMELTLIDYDMVHYHPSKVAAAASCLSQKVLGQGKWNLKQQYYTGYTENEVLEVMQHMAKNVVKVNENLTKFIVSTTVFLSCGKL
Protein: Rho-GAP domain-containing protein (O01585)
Organism: Caenorhabditis elegans
Interaction partners:
- Ras-like GTP-binding protein rhoA
- Protein ECT2
- Myosin-11
- Anillin-like protein 1
- Cell division control protein 42 homolog
- Rac GTPase-activating protein 1
- Kinesin-like protein
- Pseudocleavage protein nop-1
Sequence:
MEHNDFRVVTSSSVYRKGSTTSGVIAGAGPRPNKFSYTLGEVCSTNVTLDVNVGTGWTRIRLKEVPKFIVNAFNIISKHGMDTDGIFRKEGNSVRLNRAEVQAIYKGQRDIPNDYSVIDVCTMVKRFLRDLKPPLLDSEECRARLLKKACQARISDGFLMTRDEMADVFYMEDRTIEQQTPLLSDAHASTLGYVMRQLNRIAAHSEQHKMSIENLAIVFIGSVFGDGIHDSKKTPQLRRGSKEDILAQKRHEMNVNTAAVKLLITNANLIGVRRDPYVTSNAMLRSSSAMPRCMSSGYETLSDADCLSAQTASLQRREPGPSTPLTIHRRDSEAVHKIVTARKKGEQDSKKKRSASFLPSFRDLKHRFSNMKRTKSPSPERLTTGHTAEPSKLTDICSLNLHTDPHQDPLIHRKKVARNESTTMSTGSTASGRQSRSHQNRRGNTNATPRNNGSGKSTISTMFESEQILSSGALRRLSASDRNTDAMRFAKQIMSNEQMNVAEFLLSEHQRNRESKIRKRNTVILGEKPRSNGVKLTNRRHTAPISNRLRRNRPNTVGASLPHRNDSFLNNGSSMEEKENQADCETDDTLDATNNVDQSEWLLEQKALEARSRREGRKNKAAPMRHISTGSMLVLNGSMAVESTSMLKAEPLVMDSLKEESPQSPQKTPKVVLRKDLDNLKKMKKFCDIATSPMVMDTPTKLSHENGHAWVGTKQVVSVTRTPSLSRRRSRAHLSYSKATESPLDKPSEVRRESSSLMSPLLKHVTMTNNSAPSQVITSSPRTNLTPRSHTLSPLAVKIKRSTPPPIPPHSPPHLTPGKSEVSLDALDDMKRISISDGSRRIPTSPSHPRMPKTFSPKLPIRSVSIDNRFEFPVAAAGEPEEPSTQFKLPQLPMPKKMNRSGISPLARQAHSSKSTLSVPNRSNLRETKSIEETPTALRSAPAQASYQGSSNQMSPRSSDYFEFGKYTNALRSATDEFALPSRKASVESRPSVAILRNNNCGLVRSRVNHFQEIEHLQRVETSMSGRLSAMSQSSLRSNDPFSDRFSDVSDLRNAAFSESTDSAISTPTATPTTSRVSNDAGQYF
Protein: Pleckstrin homology domain-containing family A member 8 (Phosphatidylinositol-four-phosphate adapter protein 2) (B5MDU3)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004198}.
Interaction partners:
Sequence:
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALSVGMWV
Protein: At1g52720 (F6D8.3) (Q9SSS6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serine-threonine kinase receptor-associated protein
- Disease resistance protein RPP2B
- Coiled-coil protein
- Putative leucine-rich repeat receptor-like protein kinase At2g19210
- Expressed protein
- Thioredoxin-like 3-2, chloroplastic
- Large ribosomal subunit protein uL1c
- F-box/kelch-repeat protein At5g49000
- Small ribosomal subunit protein uS11y
- Transmembrane protein
Sequence:
MALIITCSALPTIRASSGSGSLNPDQNRKKSAAWWAPLFGLPSDPDYLNIESSCSTVNPDKTDISGSGQKFRRGCFTEEKAKQLRRKTAEASTFHDVMYHSAIASRLASDITGRVED
Protein: Long-chain fatty acid transport protein 2 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Phytanate--CoA ligase) (EC 6.2.1.24) (Solute carrier family 27 member 2) (Slc27a2) (THCA-CoA ligase) (EC 6.2.1.7) (Very long-chain acyl-CoA synthetase) (VLACS) (VLCS) (EC 6.2.1.-) (Very long-chain-fatty-acid-CoA ligase) (O35488)
Organism: Mus musculus (Mouse)
Function: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (By similarity). May contribute to the synthesis of sphingosine-1-phosphate (By similarity). Does not activate C24 bile acids, cholate and chenodeoxycholate (By similarity). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. However, it is not critical for THCA activation and bile synthesis in vivo (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O14975}; Multi-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:20530735}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97524}. Cell membrane {ECO:0000269|PubMed:20530735}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000250|UniProtKB:P97524}.
Interaction partners:
- Peroxisomal acyl-coenzyme A oxidase 2
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Long-chain-fatty-acid--CoA ligase 1
- Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Platelet glycoprotein 4
Sequence:
MLPVLYTGLAGLLLLPLLLTCCCPYLLQDVRYFLRLANMARRVRSYRQRRPVRTILRAFLEQARKTPHKPFLLFRDETLTYAQVDRRSNQVARALHDQLGLRQGDCVALFMGNEPAYVWIWLGLLKLGCPMACLNYNIRAKSLLHCFQCCGAKVLLASPDLQEAVEEVLPTLKKDAVSVFYVSRTSNTNGVDTILDKVDGVSAEPTPESWRSEVTFTTPAVYIYTSGTTGLPKAATINHHRLWYGTGLAMSSGITAQDVIYTTMPLYHSAALMIGLHGCIVVGATLALRSKFSASQFWDDCRKYNVTVIQYIGELLRYLCNTPQKPNDRDHKVKKALGNGLRGDVWREFIKRFGDIHVYEFYASTEGNIGFVNYPRKIGAVGRANYLQRKVARYELIKYDVEKDEPVRDANGYCIKVPKGEVGLLVCKITQLTPFIGYAGGKTQTEKKKLRDVFKKGDIYFNSGDLLMIDRENFVYFHDRVGDTFRWKGENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGRIGMASLKIKENYEFNGKKLFQHIAEYLPSYARPRFLRIQDTIEITGTFKHRKVTLMEEGFNPTVIKDTLYFMDDAEKTFVPMTENIYNAIIDKTLKL
Protein: Nucleoprotein (Nucleocapsid protein) (I7CAR3)
Organism: Iris yellow spot virus
Subcellular location: Virion {ECO:0000256|ARBA:ARBA00004328, ECO:0000256|PIRNR:PIRNR003948}.
Interaction partners:
Sequence:
MSTARVKASEIEKLLSGGDADVVIESDETEGFNFKNFVVANEGIRMTFNNGYTILRNRAGIYKTIKSGKFTFQNKPIIIPSANVSPSQDDWTFRRLEGFIRARMLVELLETKNEKEKQKMYEKICGLPLVSAYGLKPSDKFDATTARIMLTLGGPFTLLASLDSFAAAALPLAYFQNVKKEALGISRFSTYEQLCKVARVMAAKEFKFTDRYKKIFDETVKILTKCTPGTSGAASLVKFNEQIQILEGAFGKIVEDIGQSSKPKNPSKNDRY
Protein: Progestin and adipoQ receptor-like protein 1 (Q94177)
Organism: Caenorhabditis elegans
Function: Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Long-chain-fatty-acid--CoA ligase
- Immunoglobulin domain and leucine-rich repeat-containing protein 2
- Glycoprotein hormone subunit beta domain-containing protein
Sequence:
MNPDEVNRALGHYLNDADSGELVVEDSTTVQVKNPEARKTGDKIEVFYSRKTTVVSPTNSDDEDADFCSDSELLPQQEGHRSRATSFAGRIRAGSDDEAMPKHTILRYRRKKGGQWREINLQGTPDKRKDDEDELEVDVKEDRSEQTGIVTKTYEARWKVLKYEHLPEWLQDNEFLRHGHRPPLPSFSECFKSIWSLHTETGNIWTHLIGCVAFFFLACWFLTRPDNHIQFQEKVVFSFFFAGAVLCLGLSFAFHTLSCHSVNVVKIFCKLDYMGISLLIIGSFIPWIYYGFYCRREPKITYIAMVSVLGIGAIVVSLWDKFSESRFRPIRAAVFVGMGCSGVIPTIHYIITDGVHSLFADNSFHWLLLMAFLYLLGAGLYATRTPERFFPGKCDIWFQSHQLFHTCVVIAAFVHYYGISEMAFARLNEQCPVR
Protein: Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Q9VHR8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Degrades neuropeptide proctolin (RYLPT) by cleavage between Tyr and Leu residues.
Subcellular location: [Isoform 1]: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:12846841}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:12846841}.
Interaction partners:
- Mitochondrial inner membrane protease ATP23
- Peptidase M3A/M3B catalytic domain-containing protein
- Xaa-Pro dipeptidase
Sequence:
MFWLRGLQRSRQQLNRLCHFRSRLNYGTSPSIRSVQPSISRSLGFCSSLVRYSCSTNLPQPAEMASKTAHFVLPNTQPIADLDCKSAFENLTEKEKLYAHHFSQASWDGGLIALIQSSPEAPLIFSLLHRIFLAEKIPVLRAKALEAGVSADDFTAFLVYACGVFANAGNYKGMGDSKIVPNLSEKQFETIVKASAAYSDEPRVGKIFEKVKNLIYALESRNEILGFAPDGITTYWSDNCTKEDSEIVNAWLTSKRIEPYMCRTFKIVENGQTVYDVKLGSVAESTQDGITLPLEEYNGNKFRVTRGDYQKLLQRVNQHLLQAQKYAANENESKMIEHYVRSFEQGSLDEHKNGSRWWIKDKGPVIETYIGFIETYRDPAGGRAEFEGFVAMVNKESSAKFSELVNRAEKLIEYLPWTEPYEKDSYLKPDFTSLDVLTFAGSGVPAGINIPNYDEIRQDEGFKNVSLGNVLANINRKDPIPFLTEEDQTLMKEYKVKAFEVQVGLHELLGHGSGKLFRIDENGVYNFDKENTKNLVTGEPITKWYLPGETYDTKFGAIGSSYEECRAEAVGLYLSLQRDILEIFGFKDKAEQDNIIYVNWLSLIWNGMGVALEMFNPKSKLWLQAHSRARFVIMKVLLEAGEGLVKVEETEKGKNLLLTVDRSKIDTVGRKALGDFLTKLQVYKSTADIEAASKMYEHYSKVDESGSHPWAKWRDICLAHKKPRMILVQANTAIGQDQKVQLKTYEPTHEGYIQSWVERYPNTDIDDLLESIVEKDKKYFPTAFNN
Protein: Nucleotide-binding oligomerization domain-containing protein 1 (mNod1) (Q8BHB0)
Organism: Mus musculus (Mouse)
Function: Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses. Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the receptor interacting protein-2/RIPK2. RIPK2 subsequently recruits the kinase TAK1 to activate NF-kappa-B and MAPK signaling pathways. Regulates also antiviral response elicited by dsRNA and the expression of RLR pathway members by targeting IFIH1 and TRAF3 to modulate the formation of IFIH1-MAVS and TRAF3-MAVS complexes leading to increased transcription of type I IFNs. Besides recognizing pathogens, participates in surveillance of cellular homeostasis through sensing and binding to the cytosolic metabolite sphingosine-1-phosphate and then initating inflammation process (By similarity). In addition, plays a role in insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, NOD1 and RIPK2 localize to insulin vesicles where they recruit RAB1A to direct insulin trafficking through the cytoplasm.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9Y239}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Y239}. Apical cell membrane {ECO:0000250|UniProtKB:Q9Y239}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9Y239}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y239}. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells. {ECO:0000250|UniProtKB:Q9Y239}.
Interaction partners:
- Receptor-interacting serine/threonine-protein kinase 2
- Autophagy-related protein 16-1
- Protein SGT1 homolog
- Nucleotide-binding oligomerization domain-containing protein 2
- Caspase-1
- Toll-like receptor 2
- NLR family CARD domain-containing protein 4
- TNF receptor-associated factor 6
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Baculoviral IAP repeat-containing protein 3
Sequence:
MEEHGHHEMEGTPLGCHSHIKLLKINREHLVTNIRNTQCLVDNLLENGYFSAEDAEIVCACPTKPDKVRKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRLWLSEIGFSPSQLIRTKTIVNTDPVSRYTQQLRHQLGRDSKFMLCYAQKEDLLLEETYMDTLMELVGFNNENLGSLGGLDCLLDHSTGVLNEHGETVFVFGDAGVGKSMLLQRLQSLWASGRLTSTAKFFFHFRCRMFSCFKESDMLSLQDLLFKHFCYPEQDPEEVFSFLLRFPHTALFTFDGLDELHSDFDLSRVPDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTARTGVEVPRQLLRKKVLLRGFSPSHLRAYARRMFPERTAQEHLLQQLDANPNLCSLCGVPLFCWIIFRCFQHFQTVFEGSSSQLPDCAVTLTDVFLLVTEVHLNRPQPSSLVQRNTRSPAETLRAGWRTLHALGEVAHRGTDKSLFVFGQEEVQASKLQEGDLQLGFLRALPDVGPEQGQSYEFFHLTLQAFFTAFFLVADDKVSTRELLRFFREWTSPGEATSSSCHSSFFSFQCLGGRSRLGPDPFRNKDHFQFTNLFLCGLLAKARQKLLRQLVPKAILRRKRKALWAHLFASLRSYLKSLPRVQSGGFNQVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKLAFCNACSADCSALSFVLHHFHRQLALDLDNNNLNDYGVQELQPCFSRLTVIRLSVNQITDTGVKVLCEELTKYKIVTFLGLYNNQITDIGARYVAQILDECRGLKHLKLGKNRITSEGGKCVALAVKNSTSIVDVGMWGNQIGDEGAKAFAEALKDHPSLTTLSLAFNGISPEGGKSLAQALKQNTTLTVIWLTKNELNDESAECFAEMLRVNQTLRHLWLIQNRITAKGTAQLARALQKNTAITEICLNGNLIKPEEAKVFENEKRIICF
Protein: Uncharacterized protein, isoform C (A8JUR0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPQTGIVWLTIEHRLQSRPAYQMKKSKSYTLEAPDGGWGILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPVEWHMRRVPIQPEEQEELKELSPTVVIRVQPETPLKATREEPNFHTADPGARKLSHAEEQMLKVLSSRASSITSLGNWSGPVVVSDASPQMMHSLQTSRRPSTIAGASGAVAPAHATKKSWVRTIVDFLDLTLLKKPIFVNIVLGITFALYSDITFFTMQPVYLFELGYSRPDTATIIAIGAAADLASRIFLAITAVCIQVPSRYIYLAGAVFTVFARFAFNGITQFVGMACITAVIGFLRTWLHVPLPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIVGFIRDKTRDYIFVFHILNGFMILCAAPWVLEVLIVKFRRRNKIERNNVDHEDVDNQGRSAMVQ
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F4JGW8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGCFSSKHRKTQNDGGGERSIPIIPVQTHIVDQVPDHRKPQIPSPSIPISVRDPETILGKPFEDIRKFYSLGRELGRGGLGITYMCKEIGTGNIYACKSILKRKLISELGREDVKTEIQIMQHLSGQPNVVEIKGSYEDRHSVHLVMELCAGGELFDRIIAQGHYSERAAAGTIKSIVDVVQICHLNGVIHRDLKPENFLFSSKEENAMLKVTDFGLSAFIEEGKIYKDVVGSPYYVAPEVLRQSYGKEIDIWSAGVILYILLCGVPPFWADNEEGVFVEILKCKIDFVREPWPSISDSAKDLVEKMLTEDPKRRITAAQVLEHPWIKGGEAPEKPIDSTVLSRMKQFRAMNKLKKLALKVSAVSLSEEEIKGLKTLFANMDTNRSGTITYEQLQTGLSRLRSRLSETEVQQLVEASDVDGNGTIDYYEFISATMHRYKLHHDEHVHKAFQHLDKDKNGHITRDELESAMKEYGMGDEASIKEVISEVDTDNALSPVEIMREVALEIGVPVNTFKQNNVQEDGLYLPVLNNAA
Protein: Interleukin-8 (IL-8) (9E3) (C-X-C motif chemokine 8) (CEF-4) (Chemokine (C-X-C motif) ligand 8) (Embryo fibroblast protein 1) (EMF-1) (P08317)
Organism: Gallus gallus (Chicken)
Function: May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- C-X-C motif chemokine
- C-X-C chemokine receptor type 2
- Nuclear factor NF-kappa-B p105 subunit
- Interleukin-1
- Transcription factor Jun
- Transcription factor p65
- Interleukin-8
- Interleukin-6
- C-C motif chemokine
- C-C motif chemokine 4 homolog
Sequence:
MNGKLGAVLALLLVSAALSQGRTLVKMGNELRCQCISTHSKFIHPKSIQDVKLTPSGPHCKNVEIIATLKDGREVCLDPTAPWVQLIVKALMAKAQLNSDAPL