Protein: Condensin complex subunit 1 (Non-SMC condensin I complex subunit dpy-28) (Q9U2M1)
Organism: Caenorhabditis elegans
Function: Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex function is required for proper chromosome segregation in mitosis and meiosis. As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, possibly by influencing higher-order chromosome structure. Plays a role in robust cytokinesis upon presence of chromatin obstructions. Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase, possibly through chromatin reorganization.
Subcellular location: Nucleus {ECO:0000269|PubMed:18198337}. Chromosome {ECO:0000269|PubMed:18198337}. Note=During mitosis, localizes to condensed chromosomes in both sexes. In interphase cells, diffusely distributed in nuclei of hermaphrodite embryos prior to the onset of dosage compensation. Localizes to the X chromosome after the 40-cell stage when dosage compensation is initiated in hermaphrodite (XX) but not in male (X0) embryos, where it remains diffusely nuclear. {ECO:0000269|PubMed:18198337}.
Interaction partners:
- Chromosome condensation protein dpy-27
- Condensin complex subunit dpy-26
- Condensin complex subunit capg-1
- Structural maintenance of chromosomes protein 4
- Mitotic chromosome and X-chromosome-associated protein mix-1
- Uncharacterized protein C30G12.6
- CAP-G condensin subunit
- Condensin-2 complex subunit hcp-6
- Condensin-2 complex subunit kle-2
- Lysine-specific demethylase 9
Sequence:
MPRKQRVVTTPSPPTSDEDEDMDFGSTSQQQQQQPTRNNDGLSGFKSITEIIAEADNNIPSEQIDKDIDSFSSYSDISDWRGIPKFFPSLSSLSRRASTYENWENRFKVVDYLVSCSGALKDSVSDYVADYFEKNESGEDHSVDVELVHAVSMFVILTQRLTVQLQLYVSKSIASANQQAKRGTGRGGRQVDLDDDIVKWKDIQRHRMINCLLELLELRVDTVAGTKKKAIQYVFAPDVMEKDFLLRFLDTVVQLLEDPENMARSSQQWISHYFRILKVLSADYGMTKDVANCLFTALSHSYLEAANTFPFIEPLVTLMKENGEGSGRIYQPLRNVLQLVICRVGNLYAGERAEKPPPKAFCMMVQSLAINVHDLMLQDITHVYRLLQNQHVNVRMSTLHALADMFSSSYLSQSLCDTFASRRLKREGIFKRLLAHTNDEATNVRSKAVSLLRNIMENRRIPEEFESCGLLSIVGSRLNDKSVQVRKSAIQFLTTFLDNNRHGHDFNREMHQLKLNAKCSELRNAEEPQSKAIQGAENAFRQNLFTLTAGVRVEVYDIFRRRYRVEPERSITDILTGLFSPGSGNRLVRYYVAQENFPFRDRIPSLRERRSDDMEDDDDDTVSLEDDDMTSLVSEVVKWVVAQAEEDYVTFKVQLTQMDDDQLLENEQEARDRNNQIMQLRAQVQQLINKMSIEQELSRCVTIALRCVLNGETAEIKEGIRFLTRCKLFEITGADDAIRSMCSLVWRPSADILNELIEAAEDMFISRLDGNEKASERDSSTVENLMKAMNGVTEKDRPSVEEVIYLLAATELVHVDSDKNKVPRKRRPIEANVINKLWMIALDMSHGINSRKIDALRILYPISRSERGIAEARSRLRVVQKKLMDPELAVDALRIISILGTPTKLENEQDAYSRPLFKIHQDDSLWKSIEKLFFYEIMKADDNPDRDWFGVIRLTITTILSLSMDVNVMLPKLASHFVYRTKRISDFFLFYCDQVDDATDDTRKKMAQRRREYWALTYCRVMEKLMAFIGEVAVQLNAYIQVTIPKLHTRYVSKMVDAEKNDANIREEPVRFLSDLEKSVAQRKTIFTVPQDTTPGATSNDLHHLVSVMCDKRLFVPNKLMGRLLPIVVYGMRCKIMPTRIRHAATVAYGKMMPLSAEISAFAAPSFFSAMTKSSSILLRCNLVAACCDFAFAQPTLFELFAQSLFRMSQDESPLARESTILVLSHLMSNDMIQTRGVLSEAARCICDPTRAVRDVAQSFFKELNSRTDTIIQLLPEFLYHLSNGNERMSFKSYKTVFEFLIQLLKDKPKASADSMIDRVCIKFSNTDMNDSETPKYLLVALAKFVQNDGGLHRLQDNWRHWSKFMCHPSVAKEYRMMVEHMHSTSKNDEFKSQCVELIDNINKIESEGLRKEDVAIGSSITKNKGRAKKNPTTMSGSSRTTSRAANSRRRAPPPAQSDEDDSDSDDAPAAPRSAARRKAKKSAVADDDSDSDEFMLDD