wanglab/gogpt-training-data huggingface dataset:
Protein: Na(+)-translocating ferredoxin:NAD(+) oxidoreductase complex subunit C (EC 7.2.1.2) (Rnf electron transport complex subunit C) (H6LC32)
Organism: Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)
Function: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Couples electron transfer from reduced ferredoxin to NAD(+) with electrogenic movement of Na(+) out of the cell. Involved in caffeate respiration.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00461, ECO:0000269|PubMed:19222539}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00461}.
Interaction partners:
- Na
- Na
- Na
- Na
- Na
- Pyruvate:ferredoxin oxidoreductase
- Hydrogenase large subunit-like protein
- Iron hydrogenase HydB
Sequence:
MNVKHGTFKGGIHPPYRKESTAEVPLGFGKKPEMVIIPMSLHIGAPCTPIVKKGDTVFLGQRVGEPNGFVSVPVHASVSGKVIAVEERPHASGDRVMSVVIESDGLDTIDPSIKPYGTLEDMDADAIKKMVLNAGIVGLGGATFPTHVKLAIPPDKKVDCVVLNGAECEPYLTADHHLMTSQAEKVVMGLKLAMKSVGVEKGFIGVEDNKTDAIEALVKAIGNDSRLEVYSLHTKYPQGAEKQLIAAITGREVPSGALPADAGVVVMNVGTAAQIAESMITGLPLYKRYLTCTGDAIKNPQTIEIRIGVPFQSVIDQCGGFSSEPGKVISGGPMMGVTQFVTDIPVMKGTSGILCLTKESAKIATPSNCIHCGKCVGVCPIHLQPLNIAEYSQRNMWDKCESNNAMDCIECGSCSYICPAKRTLVSSIRVAKREIIAQRRKGN
Protein: LD39136p (Q7K1V0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSENAKNNSCLHCSVFSTKYQYQEIFDEFGIELGLQSLLSRHYQLEVSPDPQKQQLLCEVCVTNLIRLFDIDELEREREAAKDAAQGKDSKAEEDPIIITEVQATPPAAKPAKKTVPSRPLTKVLRPVPIIPTREPSARIRNRAAAASNVTPDTSRSPEPPETPSTEDAVSKSEPKLVSKVADQEHFSVLIQNILDEEEAVVEDETAVKEESSEAVQVTEETEAPGQIVILNSEAVTDTNPDENVYIYEHEDVMDPNLDNVKVKPISCSSRLVAQAEESQSDDDIDEGETSNVVLFNFVDIKEKDEVDNIPEYLATVVKTSFEKLTFQWCTVCKHCSLKCPTFESLFSHLSKAHKSRRDVYECPIEGCNKELKGRKFLAMHLVLLHAPVAEIPIYGSCPECKLTFSNILQYNKHSCAHVIKKKRGFRSYCEMCSLEFPSWKRFNFHSQFHLEKHRPRACFVCDYATTNIDELFQHLNYSHEPVGTLFCDLCDRTFRDPSVFMEHNKSHANVSSTTYSCSECMANFESRGRLNGHMRAMHGSVISCELCSREFATEATYNIHMKKHLIIEKDVHVCSTCGLLSDSRETLLAHVNSVKTACFGSKIDVELLRDAYVCEYCSSYFKEKDCLQAHRDSGVHKDGVFLCQPCGKEFPHMKLYRHHLRNYQQLRSDSTHRRLEICVYYMCDQENCTESYVNWNSLYTHKRRTHESASKQAEKSSKSAQEWVCQFCLKECRSKMSLSVHVARSHNNDNVTCPLCNSSYKSHDALAKHHAYWHEPIECPECFKIVKNRRNYDTHVNVVHSNKKRYSCSVCQKGFYHKSEMEAHQKLHGQSYSCEQCSFTTRNKKSLSVHVLGQHYKRFAFECNVCKKRFGRSQGLKTHMQRAHGDKYTCRDYFDGGCGRTFVNSSQLNVHVRKIHDGIILLQEDVVEEDEYITDDAPSTSKKRRLNENNEFIEEADGDDIVMEDDDEEADDFIDEIPDEDTQN
Protein: Septin homolog spn7 (O60165)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation. Binds phosphatidylinositol 4-phosphate.
Subcellular location: Cytoplasm. Nucleus. Forespore membrane; Peripheral membrane protein. Note=The sporulation-specific septin complex associates to the forespore membrane and forms partial or complete ring-like structures that curl around each haploid nucleus.
Interaction partners:
- Septin homolog spn2
- Septin homolog spn5
- Septin homolog spn6
- Septin homolog spn4
- Septin homolog spn1
- Septin homolog spn3
- Uncharacterized protein C7D4.08
- L-type lectin-like domain-containing protein C4F6.05c
Sequence:
MNKGPRHRPKFLSKKGKKLRIMVAGSSYTSYQACINSLCSKQILEAETEIDPLKAHIDRILEIREFNADILEDEFHVDLTVIEVNGFGDKIDNSASFEVVTHYLESQFDQALIEESKIKRNSKFTDTRVDALLYFIAPRGHCLSEFDLEAMKRFSKRVNVIPVIGNSNAFTEEELKNFKDVIMKDLKQCNIKVFDFPWDPEEDEDEVIEDNKRLWESVPFAVSGGVSEEDEEGYQRIVKKFQWGTFVIDDPAHSDFLNLKTVLFISHLDILKSITKQTYYENYRTEKLSNDSPSNTSLSLQKQNSIVANEDKRSVNGSERTETRSSIDQSEMRTNVSDSTKSEELKKINSIKVDNTSSLKCDSYGNTKTKTNQLNCEQIGLEVISPKEFPHRTTSSRNSLPNNTTKELEMKKMDDLSHERYENLPFYR
Protein: DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) (O13807)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of an E3 ubiquitin-protein ligase that includes cul4 (By similarity). Required for ubiquitination and the subsequent degradation of the DNA replication licensing factor cdt1 and of the ribonucleotide reductase inhibitor spd1. Also required for transcription-coupled nucleotide excision repair.
Subcellular location: Nucleus {ECO:0000269|PubMed:12181326}.
Interaction partners:
- Cullin-4
- Cell division cycle protein cdt2
- RING-box protein pip1
- WD repeat-containing protein 21
- DNA excision repair protein ckn1
- COP9 signalosome complex subunit 1
- WD repeat protein iqw1
- S-phase delaying protein 1
- Histone-lysine N-methyltransferase, H3 lysine-9 specific
- Cullin-1
Sequence:
MTYVTYLHKPSSIRNAVFCKFVNASSWNVIVAKVNCLEVYSYENNRLCLITSANIFAKIVNVKAFKPVSSPTDHIIVATDSFRYFTLFWDANDNTVSNGIKIQDCSERSLRESQSGPLLLVDPFQRVICLHVYQGLLTIIPIFKSKKRFMTSHNNPSLHDNFSVRIQELNVVDIAMLYNSSRPSLAVLYKDSKSIVHLSTYKINVREQEIDEDDVVCHDIEEGKLIPSENGGVFVFGEMYVYYISKDIQVSKLLLTYPITAFSPSISNDPETGLDSSIYIVADESGMLYKFKALFTDETVSMELEKLGESSIASCLIALPDNHLFVGSHFNNSVLLQLPSITKNNHKLEILQNFVNIAPISDFIIDDDQTGSSIITCSGAYKDGTLRIIRNSINIENVALIEMEGIKDFFSVSFRANYDNYIFLSLICETRAIIVSPEGVFSANHDLSCEESTIFVSTIYGNSQILQITTKEIRLFDGKKLHSWISPMSITCGSSFADNVCVAVAGGLILFFEGITEVGRYQCDTEVSSLCFTEENVVYVGLWSADIIMLTYCQDGISLTHSLKLTDIPRSIVYSQKYGDDGGTLYVSTNNGYVLMFNFQNGQVIEHSLRRNQLGVAPIILKHFDSKEKNAIFALGEKPQLMYYESDKLVITPLSCTEMLNISSYVNPSLGVNMLYCTNSYISLAKMSEIRSLNVQTVSVKGFPRRICSNSLFYFVLCMQLEESIGTQEQRLLSFLRVYEKNTLSEIAHHKFNEYEMVESIILMNDDKRVVVGTGFNFPDQDAPDSGRLMVFEMTSDNNIEMQAEHKVQGSVNTLVLYKHLIVAGINASVCIFEYEHGTMHVRNSIRTPTYTIDISVNQDEIIAADLMKSITVLQFIDDQLIEVARDYHPLWATSVEILSERKYFVTEADGNAVILLRDNVSPQLSDRKKLRWYKKFYLGELINKTRHCTFIEPQDKSLVTPQLLCATVDGSLMIVGDAGMSNTPLLLQLQDNIRKVIPSFGGLSHKEWKEYRGENETSPSDLIDGSLIESILGLREPILNEIVNGGHEGTKLDISVQDLKSIIENLEKLHP
Protein: TRIM39 (A0A024RCP5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
Protein: Ribosomal protein arginine N-methyltransferase rmt3 (EC 2.1.1.319) (O13648)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in ribosomal protein rps2.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:15175657}.
Interaction partners:
- Small ribosomal subunit protein uS5
- Protein arginine N-methyltransferase 2
- Protein arginine N-methyltransferase skb1
- Ammonium transporter 2
- rRNA 2'-O-methyltransferase fibrillarin
- Ribosomal lysine N-methyltransferase 4
- Ammonium transporter 3
- THO complex subunit tho5
- PWWP domain-containing protein 1
- Histone H4
Sequence:
MLVKPMACYFEIWTRKVTTIEDFSLAIANRFKQMGSHSDSEVDWDNEEEVWEDEVHEFCCLFCDSTFTCLKDLWSHCKEAHNFDFYQVKQQNNLDFYACIKLVNYIRSQVKEGKTPDLDKLSDILRSDEYMISVLPDDSVLFSLGDELDSDFEDDNTLEIEVENPADVSKDAEIKKLKLQNQLLISQLEEIRKDKMNELTSQTTDQLSVTPKKADNDSYYFESYAGNDIHFLMLNDSVRTEGYRDFVYHNKHIFAGKTVLDVGCGTGILSMFCAKAGAKKVYAVDNSDIIQMAISNAFENGLADQITFIRGKIEDISLPVGKVDIIISEWMGYALTFESMIDSVLVARDRFLAPSGIMAPSETRLVLTATTNTELLEEPIDFWSDVYGFKMNGMKDASYKGVSVQVVPQTYVNAKPVVFARFNMHTCKVQDVSFTSPFSLIIDNEGPLCAFTLWFDTYFTTKRTQPIPEAIDEACGFTTGPQGTPTHWKQCVLLLRNRPFLQKGTRVEGTISFSKNKKNNRDLDISVHWNVNGKADSQSYVLN
Protein: Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (O88664)
Organism: Rattus norvegicus (Rat)
Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. During fetal development, it plays an essential role in the regulation of neuronal differentiation and migration to the cortical plate (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- mitogen-activated protein kinase kinase
- mitogen-activated protein kinase kinase
- Serine/threonine-protein kinase TAO2
- Serine/threonine-protein kinase TAO3
- Serine/threonine-protein kinase PLK1
- Cell division cycle protein 20 homolog
- Nuclear migration protein nudC
- Schwannomin interacting protein 1
Sequence:
MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGGGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDASDDKSELDMMEGDHTVMSNSSVIHLKPEEENYQEEGDPRTRASAPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQASMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASSWSHNPTGGSGPHWGHPMGGTPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSIGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
Protein: Putative mitochondrial transporter UCP3 (Solute carrier family 25 member 9) (Uncoupling protein 3) (UCP 3) (P56501)
Organism: Mus musculus (Mouse)
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:26915802}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Carnitine O-palmitoyltransferase 1, muscle isoform
- [Pyruvate dehydrogenase
Sequence:
MVGLQPSEVPPTTVVKFLGAGTAACFADLLTFPLDTAKVRLQIQGENPGAQSVQYRGVLGTILTMVRTEGPRSPYSGLVAGLHRQMSFASIRIGLYDSVKQFYTPKGADHSSVAIRILAGCTTGAMAVTCAQPTDVVKVRFQAMIRLGTGGERKYRGTMDAYRTIAREEGVRGLWKGTWPNITRNAIVNCAEMVTYDIIKEKLLESHLFTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNAPLGRYRSPLHCMLKMVAQEGPTAFYKGFVPSFLRLGAWNVMMFVTYEQLKRALMKVQVLRESPF
Protein: CMP-sialic acid synthase (EC 2.7.7.43) (Q8IQV0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- N-acetylneuraminate-9-phosphate synthase
- LD15807p)
- Vacuolar protein sorting-associated protein 35
- Vacuolar protein sorting-associated protein 29
- beta-galactoside alpha-
- Sorting nexin 6, isoform B
- von Willebrand factor A domain-containing protein 8
- Vacuolar protein sorting-associated protein 26
Sequence:
MIKLKPATFLILLVFLFETGCTENCLSNDIHALILARGGSKGIKLKNLAEIGGSSLLARTIMTIKNSTCFRHIWVSTDDKRIAIEAQKYGAIIHHRPEKFARDDTPSLHAISEFLDVHRSIHDFALFQCTSVFLKTKYIQEAVRKFESHDCVFAAKRSHYLRWKVVDGELMPAEFDLSARPRRQDWQGDIVETGMFYFSRRKLVDSGLLQNNRCSVVEIDAKDSLEIDSSHDLTLAKYILSSETKTEL
Protein: PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog) (Q9NWS0)
Organism: Homo sapiens (Human)
Function: Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9CQJ2}.
Interaction partners:
- RNA polymerase II-associated protein 3
- RuvB-like 2
- RuvB-like 1
- Nucleolar protein 58
- Dynein axonemal assembly factor 10
- Heat shock protein HSP 90-alpha
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Protein UXT
- p53 and DNA damage-regulated protein 1
- Heat shock protein HSP 90-beta
Sequence:
MANPKLLGMGLSEAEAIGADSARFEELLLQASKELQQAQTTRPESTQIQPQPGFCIKTNSSEGKVFINICHSPSIPPPADVTEEELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS
Protein: WW domain-containing protein (Q9XVA3)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MRKLSTRPLPLGDGFFDSSSDSSESELSDKDDEDRYSDSTVSTLTSQDRRDTQGCQYPRSSELPISESPAPRARRARKQRSKRKSVKPPNTSSDDSSDDSDDSSSSSSSDDSVSSKSSTNSSDSSPCRCRDGLAEWEQRHGRRWHPYGRNGTWEPYRNRRRGIYDCENSPRETYSNGA
Protein: Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5) (Q922U2)
Organism: Mus musculus (Mouse)
Function: Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12657653, ECO:0000269|PubMed:29518391}.
Interaction partners:
- Keratin, type I cytoskeletal 14
- Tumor protein 63
- Keratin, type I cytoskeletal 17
- Keratin, type I cuticular Ha4
- Collagen alpha-1
- Loricrin
- Keratin, type I cytoskeletal 15
- Plakophilin-1
- Aquaporin-5
- Proliferation marker protein Ki-67
Sequence:
MSRQSSVSFRSGGSRSFSAASAITPSVSRTSFSSVSRSGGGGGGRISLGGACGAGGYGSRSLYNVGGSKRISYSSGGGSFRNQFGAGGFGFGGGAGSGFGFGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTVNQNLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTIKQNLDPLFEQYINNLRRQLDGVLGERGRLDSELRNMQDLVEDYKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEARVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRSEIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTNSVSSGYGGGSSIGVGSGFGGGLGSGFAGGLGPRFTRGGGGLGLGSGLSVGGSGFSAGSSQGGMSFGSGGGSGSSVKFVSTTSSSRRSFKS
Protein: IGL@ protein (Q6PJR7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MACCAQWLHRKAGTQTLEPQLEAADPACGACGAGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
Protein: Secretory carrier-associated membrane protein (Secretory carrier membrane protein) (Q5U2U4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363122}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363122}.
Interaction partners:
- ADP-ribosylation factor 6
Sequence:
MSAFDTNPFADPVDVNPFQDPSVTQLTSAPQSGLAEFNPFSETNAATTVPVTQLPGPSQPAVLQPSVEPAQPSPQAVAAAAQAGLLRQQEELDRKAAELERKERELQNTAANLHVRENNWPPLPSWCPVKPCFYQDFSTEIPADYQRICKMLYYLWMLHSVTLFLNLLACLAWFTSDAANGTAFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFSFFVFFFVFFCQIGIYFIQLIGLPNLGTSGWLAALSTVNKGPLAVTIIMMVVAGFFTLCAGLSLFLLQRVHAFYRRTGASFQQAQEEFSQGIFSSRTFRTAASSAARGTFQGN
Protein: Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II) (P11908)
Organism: Homo sapiens (Human)
Function: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Interaction partners:
- Ribose-phosphate pyrophosphokinase 1
- Phosphoribosyl pyrophosphate synthase-associated protein 1
- Phosphoribosyl pyrophosphate synthase-associated protein 2
- Amidophosphoribosyltransferase
- Transketolase
- Ribokinase
- Ribose-5-phosphate isomerase
- Transketolase-like protein 2
- Transketolase-like protein 1
- Phosphopentomutase
Sequence:
MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
Protein: Aquaporin PIP2-2 (Plasma membrane intrinsic protein 2-2) (ZmPIP2-2) (ZmPIP2;2) (Q9ATM8)
Organism: Zea mays (Maize)
Function: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MGKDDVVQSGAGGGEFAAKDYTDPPPAPLVDAAELGSWSLYRAVIAEFIATLLFLYVTVATVIGYKHQTDASASGAGADAACGGVGVLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLVRALLYMVAQCLGAVCGVGLVKAFQSAYFDRYGGGANSLASGYSRGAGLGAEIVGTFVLVYTVFSATDPKRNARDSHVPVLAPLPIGFAVFMVHLATIPVTGTGINPARSLGAAVVYNKDKPWDDHWIFWVGPLLGAAIAAFYHQYILRAGAIKALGSFRSNA
Protein: Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Q08DU8)
Organism: Bos taurus (Bovine)
Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UL45}. Membrane {ECO:0000250|UniProtKB:Q9UL45}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UL45}. Note=It can exist as a soluble protein as well as a peripheral membrane protein. {ECO:0000250|UniProtKB:Q9UL45}.
Interaction partners:
- SNARE-associated protein Snapin
- Dysbindin
- Biosis of lysosomal organelles complex 1 subunit 4
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Hermansky-Pudlak syndrome 6 protein homolog
- Mirror-image polydactyly 1
- Hermansky-Pudlak syndrome 5 protein homolog
- Uncharacterized protein.
- Biosis of lysosomal organelles complex 1 subunit 2
Sequence:
MSVPGPPSPDGVLAGPPEGLEAGDLTPGLSDTSPDEGLIEDLTIEDKAVEQLAEGLLSHYLPDLQRSKQALQELTQNQVVLLDTLEQEISKFKECHSMLDINALFTEAKHYHAKLVNIRKEMLMLHEKTSKLKKRALKLQQKRQKEELEREQQREKEFEREKQLTAKPAKRT
Protein: Small ribosomal subunit protein uS12c (30S ribosomal protein S12, chloroplastic) (Q6ENC0)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits (By similarity).
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS14c
- Uncharacterized protein
- Small ribosomal subunit protein uS7cz/uS7cy
- Small ribosomal subunit protein uS9c
- Small ribosomal subunit protein uS7c
- Small ribosomal subunit protein uS7c
- 30S ribosomal protein S13
- 30S ribosomal protein S9
- Small ribosomal subunit protein bS16c
- S5 DRBM domain-containing protein
Sequence:
MPTVKQLIRNARQPIRNARKSAALKGCPQRRGTCARVYTINPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYRIIRGALDAVAVKNRQQGRSKYGVKKPKK
Protein: Protocadherin-17 (Protocadherin-68) (O14917)
Organism: Homo sapiens (Human)
Function: Potential calcium-dependent cell-adhesion protein.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- High affinity immunoglobulin gamma Fc receptor I
- Protocadherin-12
Sequence:
MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRALSPLLQEVPSASSSPTKACIEPCTSTKGSLDGCEAKPGALAEASSQYLPTDSQYLSPSKQPRDPPFMASDQMARVFADVHSRASRDSSEMGAVLEQLDHPNRDLGRESVDAEEVVREIDKLLQDCRGNDPVAVRK
Protein: Histone H4 transcription factor (Histone nuclear factor P) (HiNF-P) (MBD2-interacting zinc finger protein) (Methyl-CpG-binding protein 2-interacting zinc finger protein) (Q8K1K9)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.
Subcellular location: Nucleus {ECO:0000250}. Note=Associated with discrete nuclear foci. {ECO:0000250}.
Interaction partners:
- Homeobox protein goosecoid
- Protein NPAT
Sequence:
MSPPGKVPRKENLGLQCEWGSCSFVCSAMEEFFDHVTQHLQQHMHGSKEEEEEDPLEEEFSCLWQECGFCSLDSSADLIRHVYFHCYHTKLKQWGLQALQSQADLSPCILDFQSRNVIPDTPDHFLCLWEHCESVFDNPEWFYRHVDAHSLCCEYQAVSKDNHVVQCGWKGCTCTFKDRCKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHIRRQTSLDQQRFQCSHCSKRFATERLLRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRFRHSEDRPYKCDCCDYSCKNLIDLRKHLDTHSKESAYRCDFENCNFSARSLSSVKSHHRKVHEGDSEPRYKCHVCDKCFTRGNNLTVHLRKKHQFKWPSGHPRFRYKEHEDGYMRLQLVRYESVELTQQLLQQLQEGSDPGLALNESSLQGIVLETVLGGPGPEEETEEEGRVVEGTALSASQDNPSSAIHMVSQTDTQGQRDIVYCVLSEGPGEPPPVSETLKRDGKARGT
Protein: Homeobox protein ATH1 (P48731)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor which may be involved in the signal transduction pathway downstream of the COP1 gene. Controls floral competency as a specific activator of FLC expression. Is responsive of the nuclear import of SHOOT MERISTEMLESS (STM).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Agamous-like MADS-box protein AGL70
- E3 ubiquitin-protein ligase RFI2
- Homeobox protein SHOOT MERISTEMLESS
- Transcription repressor OFP11
- Adenine phosphoribosyltransferase 3
- Protein Brevis radix-like 1
- F-box protein PP2-A13
Sequence:
MDNNNNNNTFSSLDNVMTNQNPLLMDFIPSREDSTSFSTMLPWNTIRSDPLQMGGFDIFNSMLTNKYLSSSPRSIDVQDNRNVEFMAPPPHPPPLHPLDHLRHYDDSSNNMWGFEANSEFQAFSGVVGPSEPMMSTFGEEDFPFLISNKRNNELSLSLASDVSDECSEISLCAATRLASEQASCSSKDISNNVVTQGFSQLIFGSKYLHSVQEILSHFAAYSLDYSSRGTESGAASSAFTSRFENITEFLDGDSNNSEAGFGSTFQRRALEAKKTHLLDLLQMVDDRYSHCVDEIHTVISAFHAATELDPQLHTRFALQTVSFLYKNLRERICKKIISMGSVLERGKDKTQETSMFHQHCLLQQLKRKNHQIWRPQRGLPEKSVSVLRNWMFQNFLHPYPKDSEKHLLAIRSGLTRSQVSNWFINARVRLWKPMIEEMYAEMNKRKLNNSHIQPNGPTLRMPKSVMMSQAMHK