wanglab/gogpt-training-data huggingface dataset:
Protein: Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST 13-13) (GST class-kappa) (GSTK1-1) (mGSTK1) (Glutathione S-transferase subunit 13) (Q9DCM2)
Organism: Mus musculus (Mouse)
Function: Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12720545}.
Interaction partners:
- Glutathione S-transferase theta-1
- Glutathione S-transferase theta-2
- Glutathione S-transferase omega-2
- Glutathione S-transferase P 1
- Hematopoietic prostaglandin D synthase
- Glutathione S-transferase omega-1
- Glutathione S-transferase Mu 1
- Glutathione S-transferase A4
- Glutathione S-transferase Mu 4
- Glutathione S-transferase Mu 6
Sequence:
MGPAPRILELFYDVLSPYSWLGFEVLCRYQHLWNIKLQLRPTLIAGIMKDSGNQPPAMVPRKGQYIFKEIPLLKQFFQVPLNIPKDFFGETVKKGSINAMRFLTTVSMEQPEMLEKVSREIWMRVWSRDEDITEYQSILAAAVKAGMSTAQAQHFLEKISTQQVKNKLIENTDAACKYGAFGLPTTVAHVDGKTYMLFGSDRLELLAYLLGEKWMGPVPPTANARL
Protein: Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) (Q13671)
Organism: Homo sapiens (Human)
Function: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11784866}. Membrane {ECO:0000269|PubMed:11784866}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11784866}. Note=Some amount is membrane-associated.
Interaction partners:
- Tyrosine-protein kinase ABL1
- GTPase HRas
- Ras-related protein Rab-5A
- Tyrosine-protein kinase ABL2
- Ras-related protein R-Ras2
- GTPase KRas
- Ras-related protein Rab-5B
- GTPase NRas
- Ras-related protein R-Ras
- Ras-related protein Rab-5C
Sequence:
MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPEKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRAAEE
Protein: DNA-directed RNA polymerase II subunit RPB11 (RNA polymerase II subunit B11) (DNA-directed RNA polymerase II 14.1 kDa polypeptide) (P87123)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit rpb1
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit rpb4
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MNQPERYELIELMGLPKVTYELDSKSPNAAVVTLEKEDHTLANMLANQLLSDERVLFAGYKVPHPLNHNFILRVQTVEDCSPKQVIVDAAKSLITHLEEIKVNFMREWELKMISVEGVEMEFS
Protein: Long-chain-fatty-acid--CoA ligase FadD15 (FACL) (EC 6.2.1.3) (Acyl-CoA synthetase) (FACL15) (O53521)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension.
Interaction partners:
- Probable fatty acid synthase Fas
- Probable fatty-acid-CoA ligase FadD4
- Putative fatty-acid--CoA ligase fadD11
- Triacylglycerol lipase
Sequence:
MREISVPAPFTVGEHDNVAAMVFEHERDDPDYVIYQRLIDGVWTDVTCAEAANQIRAAALGLISLGVQAGDRVVIFSATRYEWAILDFAILAVGAVTVPTYETSSAEQVRWVLQDSEAVVLFAETDSHATMVAELSGSVPALREVLQIAGSGPNALDRLTEAGASVDPAELTARLAALRSTDPATLIYTSGTTGRPKGCQLTQSNLVHEIKGARAYHPTLLRKGERLLVFLPLAHVLARAISMAAFHSKVTVGFTSDIKNLLPMLAVFKPTVVVSVPRVFEKVYNTAEQNAANAGKGRIFAIAAQTAVDWSEACDRGGPGLLLRAKHAVFDRLVYRKLRAALGGNCRAAVSGGAPLGARLGHFYRGAGLTIYEGYGLSGTSGGVAISQFNDLKIGTVGKPVPGNSLRIADDGELLVRGGVVFSGYWRNEQATTEAFTDGWFKTGDLGAVDEDGFLTITGRKKEIIVTAGGKNVAPAVLEDQLRAHPLISQAVVVGDAKPFIGALITIDPEAFEGWKQRNSKTAGASVGDLATDPDLIAEIDAAVKQANLAVSHAESIRKFRILPVDFTEDTGELTPTMKVKRKVVAEKFASDIEAIYNKE
Protein: Mitochondrial genome maintenance exonuclease 1 (Q5QPE7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKMKLFQTICRQLRSSKFSVESAALVAFSTSSYSCGRKKKVNPYEEVDQEKYSNLVQSVLSSRGVAQTPGSVEEDALLCGPVSKHKLPNQGEDRRVPQNWFPIFNPERSDKPNASDPSVPLKIPLQRNVIPSVTRVLQQTMTKQQVFLLERWKQRMILELGEDGFKEYTSSSMWLNCGGLQRWITCPPTFHGCRALFPVLDQVASSTRRIYGKEKEPEYSETRIFRIGSKLLFGNIQHLLTVWEHILLFTPV
Protein: ADP/ATP translocase (ADP,ATP carrier protein) (G5EFU2)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|RuleBase:RU368008}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU368008}. Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- Probable voltage-dependent anion-selective channel
- Peptidyl-prolyl cis-trans isomerase
- TspO/MBR family protein
- Sideroflexin-1.1
Sequence:
MSGGGDSKPIDKKKEDKKGFDTRKFLIDLASGGTAAAVSKTAVAPIERVKLLLQVQDASLTIAADKRYKGIVDVLVRVPKEQGYAALWRGNLANVIRYFPTQALNFAFKDTYKNIFQKGLDKKKDFWKFFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKANEREFKGLADCLVKIAKSDGPIGLYRGFFVSVQGIIIYRAAYFGMFDTAKMVFTADGKKLNFFAAWAIAQVVTVGSGILSYPWDTVRRRMMMQSGRKDVLYKNTLDCAVKIIKNEGMSAMFKGALSNVFRGTGGALVLAIYDEIQKFI
Protein: Candida glabrata strain CBS138 chromosome L complete sequence (Q6FL40)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004589}.
Interaction partners:
Sequence:
MQFSTVASVAAVAAVASAQANVTTATATQHTTTLVTITDCEEHICSEKVSPAWVSTATVTVNDVVTLTTTWCPIETTVHNTTKPAPAPTTAKPAPAPSSAKPAPAPAPKPVTNSTVKPAPAPSSAKPAPAPSSAKPAPAPSSAKPAPAPSSAKPAPAPSSAKPAPSSKADTTTTTKFVQTTTLTSSSKAAPSTHAVSSYTGAAAKALPAAGALIAGAAALLL
Protein: Mitochondrial 37S ribosomal protein MRP2 (Q5AJZ7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Mitochondrial 37S ribosomal protein MRP4
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS5m
- Mitochondrial 37S ribosomal protein MRPS28
- Ribosomal protein
- Mitochondrial 54S ribosomal protein MRP49
- Mitochondrial 37S ribosomal protein MRPS12
Sequence:
MPFRFPVKFEIPKHAHLNARVLRDQFKRLQVAEHEVTRNALKYIARNEELPARARVEAQLQLASMPKYTSAIQIKDRCVASGNAKSVIRDFKLNRTEFRNRARAGLIPGVKVASW
Protein: Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW (P9WGU7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: May directly or indirectly regulate the accessibility of the key branch point intermediate, monoacyl phosphatidylinositol tetramannoside (AcPIM4), to the elongating alpha-1,6 mannosyltransferases which could regulate the lipoarabinomannans (LAMs) biosynthesis.
Interaction partners:
- Lipoprotein LpqB
- Large ribosomal subunit assembly factor BipA
- Alpha-
- Polyprenol-phosphate-mannose-dependent alpha-
- Possible lipoprotein LprC
- Possible lipoprotein peptidase LpqM
- Putative lipoprotein LprB
- DUF402 domain-containing protein
- Conserved alanine valine rich protein
- Conserved protein
Sequence:
MGVPSPVRRVCVTVGALVALACMVLAGCTVSPPPAPQSTDTPRSTPPPPRRPTQIIMGIDWIGPGFNPHLLSDLSPVNAAISALVLPSAFRPIPDPNTPTGSRWEMDPTLLVSADVTNNHPFTVTYKIRPEAQWTDNAPIAADDFWYLWQQMVTQPGVVDPAGYHLITSVQSLEGGKQAVVTFAQPYPAWRELFTDILPAHIVKDIPGGFASGLARALPVTGGQFRVENIDPQRDEILIARNDRYWGPPSKPGIILFRRAGAPAALADSVRNGDTQVAQVHGGSAAFAQLSAIPDVRTARIVTPRVMQFTLRANVPKLADTQVRKAILGLLDVDLLAAVGAGTDNTVTLDQAQIRSPSDPGYVPTAPPAMSSAAALGLLEASGFQVDTNTSVSPAPSVPDSTTTSVSTGPPEVIRGRISKDGEQLTLVIGVAANDPTSVAVANTAADQLRDVGIAATVLALDPVTLYHDALNDNRVDAIVGWRQAGGNLATLLASRYGCPALQATTVPAANAPTTAPSAPIGPTPSAAPDTATPPPTAPRRPSDPGALVKAPSNLTGICDRSIQSNIDAALNGTKNINDVITAVEPRLWNMSTVLPILQDTTIVAAGPSVQNVSLSGAVPVGIVGDAGQWVKTGQ
Protein: Uncharacterized protein DKFZp761N1221 (Q6AHX3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}. Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
NAHAILTDATKRNIYDKYGSLGLYVAEQFGEENVNTYFVLSSWWAKALFVFCGLLTCCYCCCCLCCCFNCCCGKCKPKAPEGEETEFYVSPEDLEAQLQSDEREATDTPIVIQPASATETTQLTADSHPSYHTDGFN
Protein: ETS proto-oncogene 2, transcription factor (A0A0C4DG47)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNDFGIKNMDQVAPVANSYRGTLKRQPAFDTFDGSLFAVFPSLNEEQTLQEVPTGLDSISHDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIK
Protein: inositol-polyphosphate 5-phosphatase (EC 3.1.3.56) (Q8IMU3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MESAQEDASSTDVFLVTANVGSLFEDPERLLQLWLSEFLAKIAVAQPRFLALHLQEVGGKTYEKSMEYVQEFIRCLCDAPEMGDFTCVHIFMDEDFKSAEHFTALGSLYFVHKDVASLKIWNFLTHSWEESLQDVKDKHIYSGNIETIATKEKSKFPQHFFPECKWSRKGFMRTRWEINGTVIDLVNIHLFHDASNLAACENFPSVYCKTRRRALVHTIERFHLDEQNGTVPFFLFGDFNFRCDTEGVVKELTENLTPHRVQNVKNENDKIHYRNSTGNNVLTVGKKEFSHADHQLKFKEDWLKKFDRELEPLKDVLVEYPIKFVPSYPFEEDPEMPTDYMSTRCPAWCDRILMSPQVNEIIQSDDWTYGMIGEAVCMGDHKVLRIPQLYRSYRRAWRTW
Protein: At1g04330 (F19P19.24 protein) (O22691)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mitogen-activated protein kinase 11
Sequence:
MSSTARNISGSGNRKSSRLQRRAPPPLKINPCEANWKVAIPLLSPTESPPQKPPAVMKREEQRWGKEAEKPPVFKKWQHPAAPFYYQPAPSSNQPFAWPN
Protein: BRCA2 and CDKN1A-interacting protein (P21- and CDK-associated protein 1) (Protein TOK-1) (Q9P287)
Organism: Homo sapiens (Human)
Function: During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
Subcellular location: Nucleus {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:11313963, ECO:0000269|PubMed:15713648}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Colocalizes with BRCA2 in discrete nuclear foci (PubMed:15713648). In interphase, preferential localizes to the mother centriole (PubMed:28394342). Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (PubMed:28394342). {ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:28394342}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Isoform 1/beta tends to be less abundant at, and less strongly associated with, centrosomes than isoform 2/alpha. {ECO:0000269|PubMed:28394342}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Isoform 2/alpha tends to be more abundant at, and more strongly associated with, centrosomes than isoform 1/beta. {ECO:0000269|PubMed:28394342}.
Interaction partners:
- Breast cancer type 2 susceptibility protein
- Cyclin-dependent kinase inhibitor 1
- Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
- Protein LYRIC
- Uroporphyrinogen-III synthase
- Large ribosomal subunit protein uL14
- Cyclin-H
- Cyclin-dependent kinase 7
- CDK-activating kinase assembly factor MAT1
- Cyclin-T1
Sequence:
MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSNKKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV
Protein: Ethanol acetyltransferase 1 (EC 2.3.1.268) (Acetyl-CoA hydrolase) (EC 3.1.2.1) (Acetyl-CoA thioesterase) (Alcohol acetyltransferase) (AAT) (Ethyl acetate esterase) (EC 3.1.1.-) (P53208)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Alcohol acetyltransferase that catalyzes the synthesis of ethyl acetate from ethanol and acetyl-CoA. Can also function as a thioesterase by hydrolyzing acetyl-CoA in the absence of ethanol, as well as esterase hydrolyzing ethyl acetate (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Alcohol O-acetyltransferase 1
- Medium-chain fatty acid ethyl ester synthase/esterase 1
- Medium-chain fatty acid ethyl ester synthase/esterase 2
- Isoamyl acetate-hydrolyzing esterase
- N-acetyltransferase SLI1
Sequence:
MSRLAHNKALPYKIIVDLSFHRTRLPSDVSSLIKFEQRPAIINIHGLLGSHVMFHSLNKLLSRKLDADIFSVDVRNHGISPKAIPYDYTTLTNDLIYFIETHIGLERPIYLLGFSMGGKIALLTTLYKNINIRKCISIDLPPYETPELDPMILQNYDLIMRIIRRDVKILRGSPSWQKKVLELFKSLECNKRKCGGAVALYFANGFLSVKSNNVHQAQLHYEQQQHDPYINYSMPLSSMPNLLDEVKKWPDLSNQRDFFQKGTASRKVLFMKGLQSNFINNDYSLLRYNFPCADVREFNTGHNLLLENPEDSFKCILNFFAEETLDFE
Protein: Probable succinate dehydrogenase [iron-sulfur subunit] (Succinic dehydrogenase) (O53670)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Succinate dehydrogenase 2 membrane subunit SdhC
- Probable succinate dehydrogenase [iron-sulfur subunit]
- Probable succinate dehydrogenase [membrane anchor subunit]
- Probable succinate dehydrogenase SdhD
- succinate dehydrogenase
- Fumarate reductase iron-sulfur subunit
- Succinate--CoA ligase subunit beta
- Succinate--CoA ligase subunit alpha
- Fumarate reductase subunit C
- Fumarate reductase subunit D
Sequence:
MVEVERHSYDVVVIGAGGAGLRAVIEARERGLKVAVVCKSLFGKAHTVMAEGGCAAAMGNANPKDNWKTHFGDTMRGGKFLNNWRMAELHAKEAPDRVWELETYGALFDRTDDGRISQRNFGGHTYPRLAHVGDRTGLELIRTLQQKVVSLQQEDHAELGDYEARIKVFAECTITELLKDQGAIAGAFGYWRESGRFIVFEAPAVVLATGGIGKSFKVTSNSWEYTGDGHALALRAGATLINMEFVQFHPTGMVWPPSVKGILVTEGVRGDGGVLKNSENSRFMFDYIPPVFKGQYAETEEEADQWLKDNDSARRTPDLLPRDEVARAINSEVKAGRGTPHGGVYLDIASRLTPAEIKRRLPSMYHQFKELAEVDITTQAMEVGPTCHYVMGGVEVDADTGAATVPGLFAAGECAGGMHGSNRLGGNSLSDLLVFGRRAGLGAADYVRALSSRPAVSAEAIDAAAQQALSPFEGPKDGSAPENPYALHMDLQYVMNDLVGIIRNADEISRALTLLAELWSRYHNVLVEGHRQYNPGWNLSIDLRNMLLVSECVARAALQRTESRGGHTRDDHPGMDPNWRRILLVCRATETMGTGGSGSGDSNCHINVTQQLQTPMRPDLLELFEISELEKYYTDEELAEHPGRRG
Protein: Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) [Cleaved into: ADGRG6 N-terminal fragment (ADGRG6-NTF); ADGRG6 C-terminal fragment (ADGRG6-CTF)] (Q6F3F9)
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons these functions are mediated via G-protein-signaling pathways. Regulates also neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q86SQ4}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- L-selectin
Sequence:
MMFDTLGKRCCPWRLKPSALLFLFVLCVTCVPLSVCGCGSCRLVLSNPSGTFTSPCYPNDYPNTQSCSWTLRAPAGYIIQITFNDFDIEEAPNCIYDSLSLDNGESQTKFCGATAKGLSFNSSVNEMHVSFSSDFSIQKKGFNASYIRVAVSLRNQKVILPQTLDAYQVSVAKSISIPELKAFTLCFEASKVGNEGGDWTAFSYSDESLTQLLSLEKASNGYFLSISGSRCLLNNALPVKDKEDIFTENLEQLCLVWNNSWGSIGINFKKNYETVPCDSTISAVVPGDGTLLLGSDRDEVASLRGSIYNFRLWNFTMDLKALSNLSCSVSGNVIDWHNDFWSISTQALKAEGNLSCGSYLIQLPAAELTNCSELGTLCQDGIMYRISVVIHNDFNHPEVKVQTKVAEWLNSTFQNWNYTVYVVNISFHQKVGEDRMKVKRDIMDDDKRLVLWALLVYNATNNVSLNEEKIKQKLMTNNASLEDGLRLCEVDVNQLGMCSALEDPDGFSWPATLPSVYKQPCPNKPGFFMTRACLSNGTSTFWGPVDTSNCSRQSNEVANEILNQTGDGQNLTSANINSIVEKVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSTEALKTIDELAFKIDLNSTPHVNIETQNLALGVSSLIPGTNAPSNFSIGLPSNNESYFQMDFGNGQTDPLASVILPPNLLENLSPEDSVLVRRAQFTFFNKTGLFQDVGSQRKVLVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHHPICAFWDMNKNKSFGGWNTSGCVAHSDLDAGETICLCSHFTHFGVLMDLPRSASQIDGRNTKVLTFITYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSSALLFLNLIFLLDGWVTSFGVAGLCTAVAALLHFFLLATFTWMGLEAIHMYIALVKVFNTYIHRYILKFCIIGWGLPALVVSIILVSRRQNEVYGKESYGKDQDDEFCWIQDPVVFYVSCAGYFGVMFFLNVAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAWGPLNIPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHSDNFS
Protein: Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (Glucose-induced selective autophagy protein 7) (Pexophagy zeocin-resistant mutant protein 12) (O93922)
Organism: Komagataella pastoris (Yeast) (Pichia pastoris)
Function: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity). Involved in glucose-induced micropexophagy.
Subcellular location: Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}.
Interaction partners:
Sequence:
MTSMDIPYSQISSFVNSSFFQKVSQLKLNKYRLDDTDKAIVGSVDFKFIGKNQPTSLSVDESSFNDNITYTHAQFPVKGILKNLNTVEDFRKVDKNEFLQSQGLVVHKSIQDRSCLKDLSKLTQFFILSFSDLKGFKFIYWFGFPSLVSRWKVNKLSGLTESQIEPYESKLNEWLNARLPIEQKQAFIIDNLEFKPFEQLSSFSPDDQLNIGFIDTSSILNKCSTQLRNILYMLAYYGFENIKVYNFRFNNTTSFTLDITLAEPLTSEPKTTGWERTAQGKLGPKLADIGALVDPARLADQSVDLNLKLMKWRVMPELDLDIIKNSKVLLLGAGTLGSYVSRVLLGYGVRHITFVDNGKVSFSNPVRQPLFNFTDCLEGGAPKAETAAKALKLIFPLITSQGYNLEVPMAGHPVTDEKRQYEDYQRLVTLIKEHDVVFLLMDSRETRWLPTVLCNVFDKICITAALGFDSYLVMRHGNLFNTEHIEAEENSHRLGCYFCNDIIAPKDSTTDRTLDQMCTVTRPGVALLASSLAAELFVSILQHPLKSHAPASLHDNATVLGCLPQQLRGFLHNFETSKLEANNYEYCSACSIQVLNEYKSRTWDFVKDALNENNYLEDLTGLTKVKQESEIAEKKFQEFENGLEFSDEDSEWIN
Protein: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 3) (Glucuronosyltransferase I) (GlcAT-I) (UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (GlcUAT-I) (O94766)
Organism: Homo sapiens (Human)
Function: Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:21763480}; Single-pass type II membrane protein {ECO:0000269|PubMed:21763480}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:21763480, ECO:0000269|PubMed:25893793}.
Interaction partners:
- Beta-1,3-galactosyltransferase 6
- Chondroitin sulfate N-acetylgalactosaminyltransferase 2
- Chondroitin sulfate N-acetylgalactosaminyltransferase 1
- Beta-1,4-galactosyltransferase 7
- Adenosine 3'-phospho 5'-phosphosulfate transporter 1
- Xylosyltransferase 1
- Exostosin-like 3
- Xylosyltransferase 2
- 2-phosphoxylose phosphatase 1
Sequence:
MKLKLKNVFLAYFLVSIAGLLYALVQLGQPCDCLPPLRAAAEQLRQKDLRISQLQAELRRPPPAPAQPPEPEALPTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPLVSGLLAASGLLFTHLVVLTPKAQRLREGEPGWVHPRGVEQRNKALDWLRGRGGAVGGEKDPPPPGTQGVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGRVVGFHTAWEPSRPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLLSHLVDPKDLEPRAANCTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV
Protein: CRAL-TRIO domain-containing protein (A0A178W2W3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MENKETKQEPAAAAEQKTVPLIEDEIERSKVGIMRALCDRQDPETKEVDDLMIRRFLRARDLDIEKASTMFLNYLTWKRSMLPKGHIPEAEIANDLSHNKMCMQGHDKMGRPIAVAIGNRHNPSKGNPDEFKRFVVYTLEKICARMPRGQEKFVAIGDLQGWGYSNCDIRGYLAALSTLQDCYPERLGKLYIVHAPYIFMTAWKVIYPFIDANTKKKIVFVENKKLTPTLLEDIDESQLPDIYGGKLPLVPIQET
Protein: N-acetylgalactosaminide beta-1,3-galactosyltransferase (EC 2.4.1.122) (Q9W0L4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- N-acetylgalactosaminyltransferase 4
- Polypeptide N-acetylgalactosaminyltransferase 3
- Putative polypeptide N-acetylgalactosaminyltransferase 9
- Sulfotransferase domain-containing protein
- Mucin 30E
- Mucin related 29B
- Mucin 91C, isoform A
Sequence:
MYRNILCLVLGLIIGIQLTDFLEYFQLTDSQFASTSITQLEEGASQLATEEELALWLHNETRVLCMVLTLPKNHQSRVRRVKGTWGRRCNKLIFISSQEDRELGVIDVGVPEDRNNLYLKMRKALEYVYRNHGEDYDWFLKADDDTFVIMENLRFLLYPYDPEAALYFGHRFRTTFPQGYMSGGAGYVMSRDALRRLNLFAFNNSQFCPINNNSEDRQIGFCLQNVGVVAGDSRDEEGRDRFLPLSLKFMLPTFPTDNWLPKLTFYEPVNETGSTSGISFHYVKIHEFEMYEYLLYRLHIFGTPLSQRTLPPRLGPDELQNQLNQWAQENSTNSNAWLKQE
Protein: GH10459p (TBC1 domain family member 5) (Q9VFX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein sorting-associated protein 35
- Vacuolar protein sorting-associated protein 26
- Ras-related protein Rab6
- LD13361p
- Sorting nexin-3
- WASH complex subunit 2
- FI18122p1
Sequence:
MTVWGIEAITLNGSSARESLEHLPGNGAIRVIPEAGAMNSVERYRQEWQVLLENLDADPESLRQSAFAGDLKMSKFRSVHWALLLRVLTSEHRSWTSQRLQQRVRYDKFRADYVRNPHQLAVDCNDDPLSQSTQSVWNQYFSDQDLFAVIRQDVVRTFPGVDFFRKPLVQNAMVNILFYYAREHPYMCYRQGMHEILAPIIFVVYSDHQSLLHFSELAKTDINPTLLDVLDPAYLEADTYSLFSRLMASVESYYRVSNLVSTPGGHIEQRAESPGDNETSTEAEVIGQLNFIRDKILAKQDQHLHHYLQKMEIPLHIFGIRWLRLLFGREFMLLDLLLLWDAIFADSDRFDLPNYILVAMLVHIRDKLLLSDYTTSLTYLMRYPNNVDVHLVLRHALFMLNPKQFEYPPNAFTCVSFANSSADKDVPPPAGQRPRTNSENSSMATSGSQIDRQITFMQERNAADSSALAKLQDTHRVAMDGYLENSPELLRLELKNAQTVIKIARSKLQSYLSTVRHHVGKQANGSEELGRTLDGIEELCSFLDVKFMFPLHQRSAPIDQALEANEQKQLNTVSKPPKPTASSTPANAPAALSATGGYQMPENAFMHSSMRRLLGELREIELSTITSDEKPGNAVVQNGLPAAEPQQRHRNESS