wanglab/gogpt-training-data huggingface dataset:
Protein: Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3) (P27049)
Organism: Rattus norvegicus (Rat)
Function: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity).
Interaction partners:
- Protein arginine N-methyltransferase 1
- CCR4-NOT transcription complex, subunit 7.
- Homeobox protein
- Nuclear receptor subfamily 4 group A member 1
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex, subunit 8, isoform CRA_a.
- Cyclic AMP-dependent transcription factor ATF-3
- Krueppel-like factor 6
- Transcription factor JunB
- mRNA decay activator protein ZFP36
Sequence:
MSHGKRTDMLPEIAAAVGFLTSLLRTRGCVSEQRLKVFSRALQDALTDHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHQLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPVATSYGLLTCKNQMMLGRSSPSKNYVMTVSS
Protein: Protein transport protein Sec61 subunit beta (P38389)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Necessary for protein translocation in the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein.
Interaction partners:
- Protein transport protein Sec61 subunit gamma-1
- Protein transport protein Sec61 subunit gamma-3
- SecY protein transport family protein
- AT2G34250 protein
- F9K20.24 protein
- Preprotein translocase subunit SCY1, chloroplastic
- Translocon-associated protein subunit beta
- Protein transport protein Sec61 subunit gamma-2
- Translocon-associated protein subunit alpha
- DnaJ protein ERDJ2A
Sequence:
MVGSGAPQRGSAAATASMRRRKPTSGAGGGGASGGAAGSMLQFYTDDAPGLKISPNVVLIMSIGFIAFVAVLHVMGKLYFVK
Protein: Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (P93647)
Organism: Zea mays (Maize)
Function: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
Subcellular location: Peroxisome matrix {ECO:0000255|HAMAP-Rule:MF_03121}.
Interaction partners:
- Cyclin-SDS
- Cyclin-SDS
- glucan endo-1,3-beta-D-glucosidase
- NTF2-like
Sequence:
MSDSPVELPSRLAVLPFRNKVLLPGAIVRIRCTNPSSVKLVEQELWQKEEKGLIGVLPVRDSEATAVGSLLSPGVGSDSGEGGSKVGGSAVESSKQDTKNGKEPIHWHSKGVAARALHLSRGVEKPSGRVTYIVVLEGLCRFSVQELSARGPYHVARVSRLDMTKTELEQAEQDPDLIALSRQFKATAMELISVLEQKQKTVGRTKVLLDTVPVYRLADIFVASFEISFEEQLSMLDSVHLKVRLSKATELVDRHLQSILVAEKITQKVEGQLSKSQKEFLLRQQMRAIKEELGDNDDDEDDVAALERKMQNAGMPANIWKHAQREMRRLRKMQPQQPGYSSSRAYLELLADLPWQKVSEERELDLRVAKESLDQDHYGLTKVKQRIIEYLAVRKLKPDARGPVLCFVGPPGVGKTSLASSIAKALNRKFIRISLGGVKDEADIRGHRRTYIGSMPGRLIDGLKRVSVSNPVMLLDEIDKTGSDVRGDPASALLEVLDPEQNKAFNDHYLNVPFDLSKVIFVATANRMQPIPPPLLDRMEIIELPGYTPEEKLKIAMKHLIPRVLEQHGLSTTNLQIPEAMVKLVIERYTREAGVRNLERNLAALARAAAVKVAEQVKTLRLGKEIQPITTTLLDSRLADGGEVEMEVIPMEHDISNTYENPSPMIVDEAMLEKVLGPPRFDDREAADRVASPGVSVGLVWTSVGGEVQFVEATAMVGKGDLHLTGQLGDVIKESAQLALTWVRARAADLNLSPTSDINLLESRDIHIHFPAGAVPKDGPSAGVTLVTALVSLFSNRKVRADTAMTGEMTLRGLVLPVGGVKDKVLAAHRYGIKRVILPERNLKDLSEVPLPILSDMEILLVKRIEEVLDHAFEGRCPLRSRSKL
Protein: STI1 domain-containing protein (Q585Z8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Telomerase-associated protein, putative
- Uncharacterized protein
Sequence:
MSGAAEGSVPVPQAVTEDYKKLIFSFIQMIRSTETSTPDRVTAIVQLLGEEYGVDPAGVGGCHDTGVALLPAFQQALNEMKKSVSIQQDDKFNAFLDLLRKKGYFAGAEEGSEEYNSRLEKAREKFEKRNNPYEGMTAEEIKNKGNELMGLANYKQAVAYYTKAIEMEPENHVFFANRAAAHTHLKDYRSAIIDCERSISICPTYAKAYSRLGTTLFYQENYQRAVDAFSKACELDPTNERYREDLKQVEEKAKQSNSATAGMGGTPFGADGMFNFSQVAEVMKNPQFVETATRLMSNPQFNQAVVQMASRIGGLSDNPEEVARLMGSGMGMLSAGGDVDFTRLFGDIDREALERFKEEEAGRNPRLRAIMEDVQRNGPSAFQQHMNDPEVMNLMLKFQNILLNNGGGGANGGASS
Protein: Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase-2) (Elastase-2A) (P05208)
Organism: Mus musculus (Mouse)
Function: Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.
Subcellular location: Secreted {ECO:0000305|PubMed:31358993}.
Interaction partners:
- Chymotrypsin-like elastase family member 3B
- Carboxypeptidase A1
- Pancreatic triacylglycerol lipase
- Chymopasin
- Carboxypeptidase B
- Trypsin-5
- Bile salt-activated lipase
- Anionic trypsin-2
- Chymotrypsinogen B
- Chymotrypsin-like elastase family, member 3A
Sequence:
MIRTLLLSALVAGALSCGYPTYEVEDDVSRVVGGQEATPNTWPWQVSLQVLSSGRWRHNCGGSLVANNWVLTAAHCLSNYQTYRVLLGAHSLSNPGAGSAAVQVSKLVVHQRWNSQNVGNGYDIALIKLASPVTLSKNIQTACLPPAGTILPRNYVCYVTGWGLLQTNGNSPDTLRQGRLLVVDYATCSSASWWGSSVKSSMVCAGGDGVTSSCNGDSGGPLNCRASNGQWQVHGIVSFGSSLGCNYPRKPSVFTRVSNYIDWINSVMARN
Protein: Probable family 17 glucosidase SCW11 (EC 3.2.1.-) (Soluble cell wall protein 11) (P53189)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in cell separation.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:9748433}.
Interaction partners:
- Protein DSE2
- Protein DSE1
- Endochitinase
- Protein EGT2
- Probable secreted beta-glucosidase SUN4
- Glucan endo-1,3-beta-D-glucosidase 1
- Antagonist of mitotic exit network protein 1
Sequence:
MISPISFLSSLLCLTYLTSALPILPKREVVTRVHTASTTNVVTDFYSTTTEVVIAPTVEFLISDSVTFTTTLIPQGVNPTAEPTTTITKVLLKKAEMSTSSQPTSTLQPSTIPQSTSSFQAESTLQAVSTQQTAMSVSAGTSEDVQQLATTSTSISSSPSPTTTSTSTQNIVSGVGEANVEGNTQSQHHSYQAAATSTLNQQTSTSIASQESTESTNTPTSSSTSSSTSSSTSSSTSSSTSSSTSSSTSSSTSSSTSSTQETAATTSEGSSSSSAAITSSPKAIAYSPYNDDGSCKSADAVSSDLTLIKSKGISKIRVYGTDCNSFETVQPAAVKLGIKINQGLYITSSGVDSIDDSVTTLIQYGQTNGWDVFDFITVGNEAINNGWCSVSDLISKISSVKSKLSEAGYSGQITTSEPPVSFENNPDLCKKSDIDFVGINPHAYFDTSASAETAGTFVKGQVELIQGVCGTSNVFVTETGYPSSGIQNGGNIPSTANQITAVQNILNEMDLDVTILSTYNDYWKAPGDYGIEQSFGVIEYFP
Protein: Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (UFM1-activating enzyme) (X1WER2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates ufm1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ufm1-E1 thioester and free AMP. Activates ufm1 via a trans-binding mechanism, in which ufm1 interacts with distinct sites in both subunits of the uba5 homodimer. Trans-binding also promotes stabilization of the uba5 homodimer, and enhances ATP-binding. Transfer of ufm1 from uba5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9GZZ9}. Nucleus {ECO:0000250|UniProtKB:Q9GZZ9}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9GZZ9}. Golgi apparatus {ECO:0000250|UniProtKB:Q9GZZ9}.
Interaction partners:
- Ubiquitin-fold modifier 1
- Ubiquitin-fold modifier-conjugating enzyme 1
- E3 UFM1-protein ligase 1
- Ufm1-specific protease 2
- CDK5 regulatory subunit-associated protein 3.
- UFM1-specific peptidase 1
- NEDD8-conjugating enzyme UBE2F
- NEDD8-conjugating enzyme UBC12
- NEDD8-activating enzyme E1 catalytic subunit
- Molybdopterin synthase catalytic subunit
Sequence:
MATVEELKLRIRELENELIKSKQKQSDAEHNIRPKIEQMSAEVVDSNPYSRLMALKRMGIVQDYEKIRSFAVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVEAAQHTLRNINPDVAFETHNYNITTMDNFTHFMDRVSHGGLEEGKPVDLILSCVDNFEARMAINTACNELGQIWMESGVSENAVSGHIQLIIPGETACFACAPPLVVAANIDEKTLKRDGVCAASLPTTMGVVAGLLVQNVLKYLLGFGTVSYYLGYNAMQDFFPSMAMKANPQCDDRHCRRQQDEYKKKEAERPKQEVVQEEEEVVHEDNEWGIELVSEVTEAELQDASGPIPDLPEGITVAYTIPEKDGGSGETVEETEQSLEELMAQMKKI
Protein: DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Q9WUL0)
Organism: Rattus norvegicus (Rat)
Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P11387}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P11387}. Note=Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumoylated forms found in both nucleoplasm and nucleoli. {ECO:0000250|UniProtKB:P11387}.
Interaction partners:
- DNA topoisomerase 2-alpha
- Tyrosyl-DNA phosphodiesterase 1
- Cell division cycle and apoptosis regulator protein 1
- Poly [ADP-ribose] polymerase 1
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- Ribonuclease H2 subunit A
- Structure-specific endonuclease subunit MUS81
- DNA topoisomerase
- DNA topoisomerase
Sequence:
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSDKHKDKHKDRDKEKRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRPRDEDDADYKPKKIKTEDIKKEKKRKLEEEEDGKLKKPKNKDKDKKVAEPDNKKKKAKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARKDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
Protein: Sel1 repeat family protein (Q9A5L4)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- Pilus assembly protein CpaD
- Pilus assembly protein CpaA
- TadE-like domain-containing protein
- TadE-like domain-containing protein
- Regulator of CtrA degradation
- Pilus assembly protein CpaE
Sequence:
MMLMNEPPAVVSTLPLPTAESTGDELFRMGLLYSTGQGGAPLDYVSAHMLFNLAAMRGSIEAKVYRKELSQEMASEEVAEAQRQAREWLAHG
Protein: Cysteine-rich receptor-like protein kinase 7 (Cysteine-rich RLK7) (EC 2.7.11.-) (Q8L7G3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- AT5g48790/K24G6_12)
- Trafficking protein particle complex subunit-like protein
- NDR1/HIN1-like protein 1
- Protein RER1B
- Bromo-adjacent homology
- Probable calcium-binding protein CML47
- Protein transport protein SEC24 B
Sequence:
MSSLFPFIFLFLFSFLTSFRASAQDPRFLAYYCPNATTYSSNSTYLTNLKTLLSSLSSRNASYSTGFQNATVGQALDRVTGLFLCRGDVSPEVCRNCVTFAVNNTFSRCPNQREAVFYYEECILRYSHKNILSTAITNEGEFILRNPNHISPIQNQINQFTNLVLSNMNQIAIEAADNPRKFSTIKTELTALQTFYGLVQCTPDLSRQNCMNCLTSSINRMPFSRIGARQFWPSCNSRYELYDFYNETAIGTPPPPLPPLASPSLSDKSGNSNVVVVAVVVPIIVAVLIFIAGYCFFAKRAKKTYGTTPALDEDDKTTIESLQLDYRAIQAATNDFSENNKIGRGGFGDVYKGTFSNGTEVAVKRLSKTSEQGDTEFKNEVVVVANLRHKNLVRILGFSIEREERILVYEYVENKSLDNFLFDPAKKGQLYWTQRYHIIGGIARGILYLHQDSRLTIIHRDLKASNILLDADMNPKIADFGMARIFGMDQTQQNTSRIVGTYGYMSPEYAMRGQFSMKSDVYSFGVLVLEIISGRKNNSFIETDDAQDLVTHAWRLWRNGTALDLVDPFIADSCRKSEVVRCTHIGLLCVQEDPVKRPAMSTISVMLTSNTMALPAPQQPGFFVRSRPGTNRLDSDQSTTNKSVTVSIDDKSMSDLDPR
Protein: Catabolite repressor/activator (Fructose repressor) (P0ACP1)
Organism: Escherichia coli (strain K12)
Function: Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator.
Interaction partners:
- Multiphosphoryl transfer protein
- Acetolactate synthase isozyme 3 small subunit
- DNA-binding transcriptional dual regulator CRP
- Acetolactate synthase isozyme 3 large subunit
- 1-phosphofructokinase
- Adenylate cyclase
- PTS system fructose-specific EIIB'BC component
- HTH-type transcriptional regulator EbgR
Sequence:
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDAIIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVVGADQDDAEMLAEELRKFPAETVLYLGALPELSVSFLREQGFRTAWKDDPREVHFLYANSYEREAAAQLFEKWLETHPMPQALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDNELLDFLQCPVLAVAQRHRDVAERVLEIVLASLDEPRKPKPGLTRIKRNLYRRGVLSRS
Protein: HORMA domain-containing protein (MDF-2) (Q9NGT3)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- WD repeat-containing protein fzy-1
- MAD related
- Mitotic checkpoint protein bub-3
- BUB1 N-terminal domain-containing protein
- Abnormal embryogenesis protein 30
- Cell division cycle protein 27 homolog
- Mitotic checkpoint serine/threonine-protein kinase bub-1
- Cell division cycle protein 16 homolog
- Anaphase-promoting complex subunit 10
- Cell division cycle protein 23 homolog
Sequence:
MTDVKTQNAISLKGSAQLVKEFFHFGLNSILYQRALYPSDSFKREKKYGLTLWVAHEKKLQAFMDPLLQQVEYWLAKRQLKRLVMVISEVKTKEVVERWQFDIHTENLAEEGENAHRVKEEKKIRQEISDVIRQITASVSFLPLLEEPVSFDVLIYTGKDTQAPEDWTESGACLIQNSETVQLRSFSTSVHSVNTNVQYKADF
Protein: Acyl carrier protein 4, chloroplastic (Q9SW21)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carrier of the growing fatty acid chain in fatty acid biosynthesis that plays a major role in the biosynthesis of fatty acids in leaves. Required for the biosynthesis of chloroplast photosynthetic membrane lipids such as monogalactosyldiacylglycerol, digalactosyldiacylglycerol and phosphatidylglycerol. Is essential for the biosynthesis of the cuticular wax and cutin polymers in leaves, and for the establishment of systemic acquired resistance (SAR).
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- EMBRYO DEFECTIVE 3147
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Putative acyl-activating enzyme 19
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase iron-sulfur protein 6
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADPH-dependent pterin aldehyde reductase
Sequence:
MASLSTTSLSFKAPSTTISQVLRKASSSQSVTFGRFTSSTKSLRLQISCAAKAETVQKVSDIVKEQLALAADVPLTAESKFSALGADSLDTVEIVMALEEKFNISVEESDAQNITTIQEAADLIEDLVQKKPAAETS
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (DNA 3'-5' helicase BLM) (E7EZY7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTNERASCKYAMSSLPQNNLKEHLERHNNAAQNKLSLLKPKPGGFCFKKKSSSGISKVEVPQKPERVAPKVNFFTAPSKPKTNTVNPLANPFALNKTPLVQSTIKALPKSAALPKDSTNDQTVELKHDISQLSFNEWDDLDDFETPVKSRVASPVAGTSTKKPSVSDQNTSSSCSSKCEETKVNEESQATETITAPKDVLSAANGVSTETAEREPEDSPIKKSKRPKKSVQHTALLSDTEDEEIIHCVSPDTNQKNFKSVAVAEKDKWGEPNVIDSDDCEENNHYEGFEDFIPPSPIPEEISLSVSDKEKSSSEPVTPANKKESSRSASGLPAPLDQSAKGLKGADDALFSVMESICCLVDTIPEHELIALTCGTELLLQRAHRKRILAKGGSSRTSHSDSVSTPGFLNRPTFGVTPSNLTSLTPVTSGKREGVKTGFSFRKSIASVMSVGDESVFEDSDCIINGVETPGGTWNPNSSTKISAGRDTFNGSIQTLSKPESKTDKCYSRLSFNESSNQTDLFYSPKRVDSGSRNADSSVEINIAGSSSLRTGAEPVDDFLLDDFDIDDFDENDIPDYYEEPPSVLESRNNSGVKTPSVQEGGSSKSFERKTFTPPAPKSIKTPNPEPLYRNPAHDRFRGFNFPHSPEMMKIFHKKFGLHQFRFNQLEAINASLLGEDTFVLMPTGGGKSLCYQLPACVSAGVTVVISPLRSLIVDQVQKLTTLDICATSLSGDKKDSEAARIYMQLSRKDPAIKLLYATPEKVCASGRMISALQNLYERGLLARLVIDEAHCVSQWGHDFRPDYKRLHELRRMFPNVPIMALTATATPRVQKDILNQLAMTRPQVFTMSFNRNNLKYSVLPKKPKKVDEECIQWIKKYYPRDSGIVYCLSRNDCDTLADSLQRAGIAALAYHAGLSDSDREYVQNKWINQDGCQVMCATIAFGMGIDKPDVRYVIHASLPKSVEGYYQESGRAGRDGEISHCVLFYSYSDVIRIKRLIAMDKDGNQQSKATHINNLHSMVHFCENVAECRRIQLLAYFGEHTFNTSFCKEHPEVICDNCARPNKYKSRNVTDDVKKIARFVQDNCEKVGNRYGKSAQQNRLTLNMLVEIFLGSKSARIQTGMFGVGAAYSKHNAERLFKKLVLDNVLMEDLYITNSGQAVAYISAGPKAMSVLNGCMQVEFHETESASSIRKHRASVCEKVSKREEMVKKCLGELNDLCKKLGKVFGIHYYNIFSTATLKKIAETLSADPEVLLQIDGVTEDKLEKYGAEFIELLQKYSEWQLPAEAQAESSGWIDTTRGHQNDEDDNDDDDEGGGDVTSTYFRSNSGRGAKRKQGSYSRKPKRRKGSSGQNSSAKGGYSSNWSSSRGGGRGGGYRGGSRGAGRGSRSAPSGSAAKRPGFMSLPTPQAAARPFLKPSFSHL
Protein: Ictacalcin (Q91061)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Function: Plays an important role in catfish calcium homeostasis.
Interaction partners:
Sequence:
MSDLQKGMALLISTFHKYSGKEGDKCTLTKGELKDLLTKELGGAFGNCSDQATLDKIFKDLDTNADGVVDFQEYATMVACTTMLCNKSLSKK
Protein: Laccase (EC 1.10.3.2) (C0HJB2)
Organism: Sanghuangporus baumii (Phellinus baumii)
Function: Lignin degradation and detoxification of lignin-derived products. Exhibits broad substrate specificity against a range of aromatic compounds with highest activity against guaiacol. Shows lower activity against 4-methylcatechol, 4-hydroxyindole, catechol, hydroquinone and 2,6-dimethoxy-phenol.
Subcellular location: Secreted {ECO:0000269|Ref.1}.
Interaction partners:
Sequence:
AIGPVDEV
Protein: Protein OPG064 (Protein E2) (P21604)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Plays a role in intracellular enveloped virus (IEV) transport to the cell surface on microtubules. Together with protein OPG056/F12, forms a complex that interacts with host KLC2 (kinesin light chain isoform 2) to engage the kinesin-1 complex and thereby promote IEV trafficking.
Interaction partners:
Sequence:
MISVTDIRRAFLDNECHTITKAFGYLHEDKAIALIKIGFHPTYLPKVLYNNVVEFVPEKLYLFKPRTVAPLDLISTITKLKNVDKFASHINYHKNSILITGDKSLIVKCMPYMIISDDDIRFIREQFVGTNSIEYILSFINKESIYRMSYQFSENEIVTIINRDHFMYEPIYEHQVLDSDFLKTMLDRYGIVPINSGIIDELCPEAIIEILMAVVRPRDAIRFLDIVNKNQLTEDSVKNYIINDIRRGKIDYYIPYVEDFLEDRTEDLGIYANIFFEDAIDITKLDITKTELEHISKYMNYYTTYIDHIVNIILQNNYIDILASIIDYVQDVLTEELCIRIVCESTNPVPVTSLPIHSTLVMVMCIQMKYVDIVEFLDEIDIDTLIEKGADPITEYTFTTRWYNKHNDLITLYIKKYGFCPMMMKRLMFEYPLTKEASDHLLKTMDENRGAIMFFPRTICTLPYLLCCNYKLIQKPIPFKEENRNIVYKKNNRVLCFDSLENSAFKSLIKIDSIPGLKTYNMKDITYEKSNNIICVRFIPQESIHNEERRIKLQLFDIARLASYGLYYIPSRYLSSWTPVVNMIEGREYTNPQKIECLVILDLFSEEFIEYQNLGNAVSNKYELEYTISNYQAAINCLMSTLLIYLVLGSIRSISRTENFVLSILNIFYKGLKINELLSEPVSGVCIELNKIKDRASSGDSSFIFLKKNELSKTLSLCEKVCVETILDNNQSFKSSK
Protein: Probable 5-oxoprolinase OplA (5-oxo-L-prolinase) (Pyroglutamase) (5-OPASE) (P95223)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable periplasmic iron-transport lipoprotein
- Probable gamma-glutamyltranspeptidase GgtB
- Glutathione hydrolase proenzyme
- Glutamate--cysteine ligase EgtA
- Putative glutamate--cysteine ligase 2
- Glutamate synthase large chain
- NAD-specific glutamate dehydrogenase
- L-glutamate gamma-semialdehyde dehydrogenase
- Glutamate decarboxylase
- PE family protein PE22
Sequence:
MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDNPARYRDAAVAGIRALLANGEAGTRVDAVRMGTTVATNALLERTGERTLLVITRGFGDALRIAYQNRPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRAPDLEALGEKMRQAHADGIRAVAVVCLHSYLYPGHEREIGTLAQRIGFAQISLSSEVSPLMKLVPRGDTTVVDAYLSPVLRRYINQVADQMRGVRLMFMQSNGGLAQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHVIGFDMGGTSTDVSHYAGEYERVFTTQVAGVRLRAPMLDIHTVAAGGGSILHFDGSRYRVGPDSAGADPGPACYRGGGPLCVTDANVMLGRIQPTHFPSVFGPSGDQPLDAGTVRRGFTDLAADIAARTGDDRSPEQVAEGYLRIAVANMANAVKKISVQKGHDVTRYALTTFGGAGGQHACAVADALGIRTVLIPPMAGVLSALGIGLADTTAMREQSVEIPLGPAAPQRLASVAESLERAARAELLDEGVPGERIRVVRRVHLRYEGTDTAIPVQLAEIETMATAFESSHRALYTFLLDRPLIAEAISVEATGLTDQPDLSQLGDQANDTTGSSETVRIYSNGLWRDAPLRRREAMRPGDVLTGPAIIAEANATTVVDDGWQATMTETGHLLAQRVVTPPRPDAATRAGFEAGFEADPVLLEIFNNLFMSIAEQMGFRLEATAQSVNIRERLDFSCALFDPDGNLVANAPHIPVHLGSMGTTVKEVIRRRLSGMKPGDVYAVNDPYHGGTHLPDITVITPVFNTGGEDVLFFVASRGHHAEIGGITPGSMPADSREIHEEGVLFDNWLLAENGRFREAETRRLLTEAPFGSRNPDTNLADLRAQIAANQKGVDEVGKMIDHFGRDVVAAYMRHVQDNAEEAVRRVIDRLDNGAYRYRMDSGATIAVRITVDRAARSATIDFTGTSAQLDTNFNAPTSVVNAAVLYVFRTLVADDIPLNDGCLRPLRIVVPEGSMLAPTHPAAVVAGNVETSQAITGALFAALGVQAEGSGTMNNVTFGNERHQYYETVGSGSGAGDGYHGASVVQTHMTNSRLTDPEVLEWRYPVLLREFAVRQGSGGAGRWRGGDGAVRRLEFTEPMTVSTLSGHRRVRPYGMAGGSPGELGRNRVERADGSTVELAGCGSTHVEPGDTLVIETPGGGGYGPASTSARRRR
Protein: Dopamine receptor 2 (Dopamine 1-like receptor 2) (Q24563)
Organism: Drosophila melanogaster (Fruit fly)
Function: Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Dopamine D2-like receptor
- Dopamine receptor 1
- G protein alpha s subunit subunit alpha)
- G protein beta subunit 5
Sequence:
MVDDNGSSPEVEGAEGAGAPLLALLRVDGLNQTQTRSPSPSFFGSYNISEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKIRRKYQPTMRSKSQRFATRRCYSTCSLHGIQHVRHNSCEQTYI
Protein: Histone deacetylase HDAC1 (HD) (EC 3.5.1.98) (Q94517)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). In the larval brain, part of a regulatory network including the transcriptional repressors klu, dpn and E(spl)mgamma-HLH which is required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP).
Subcellular location: Nucleus {ECO:0000269|PubMed:12533794, ECO:0000269|PubMed:12697833}.
Interaction partners:
- Chromodomain-helicase-DNA-binding protein Mi-2 homolog
- Metastasis-associated protein MTA3
- CoRest, isoform G
- Chromatin assembly factor 1 p55 subunit
- Paired amphipathic helix protein Sin3a
- Methyl-CpG binding domain protein-like, isoform C
- FI07430p
- Chromodomain-helicase-DNA-binding protein 3
- Histone-lysine N-methyltransferase E
- PHD finger protein 12
Sequence:
MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSETSSEIKDEKEKGDGADGEESTASNTNSNNNSNNKSDNDAGATANAGSGSGSGSGAGAKGAKENNI