wanglab/gogpt-training-data huggingface dataset:
Protein: Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) (Q5M939)
Organism: Rattus norvegicus (Rat)
Function: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression. Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks. In addition, acetylates other substrates such as chromatin-related proteins. Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation.
Subcellular location: Nucleus matrix {ECO:0000250|UniProtKB:O14929}. Mitochondrion {ECO:0000250|UniProtKB:O14929}.
Interaction partners:
- Histone-binding protein RBBP7
- Nuclear autoantigenic sperm protein
- Histone H4
- Histone H3.1
- Histone H3
- Similar to H3 histone, family 3B.
- Histone H3
- Histone H3
- Histone H3.3
- Origin recognition complex subunit 3
Sequence:
MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEADFKPFGTLLHTYSVPSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYIASSSVLDITAEDPSKSYVKLRDFVLVKLCQDLPCFSRERLLQGFNEDMAIQAQQKFKINKQHARRVYEILRLLVTDMSDAEQCRSYRLDIKRRLISPYKKKQTDLAKMRKCLRPEELTNQMNQIEISVQHEQLEEQFQELVEDYRRVIERLAQE
Protein: Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) (O75665)
Organism: Homo sapiens (Human)
Function: Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12595504, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20230748, ECO:0000269|PubMed:26643951}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17761535}. Nucleus {ECO:0000269|PubMed:17761535}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:26643951}. Note=Localizes to centriole distal ends and to centriolar satellites (PubMed:20230748, PubMed:24121310). Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP (PubMed:26643951). {ECO:0000269|PubMed:26643951}.
Interaction partners:
- Nuclear distribution protein nudE homolog 1
- Serologically defined colon cancer antigen 8
- Pericentriolar material 1 protein
- Centrosomal protein 20
- Centrosomal protein of 290 kDa
- Protein moonraker
- Serine/threonine-protein kinase PLK1
- Coiled-coil and C2 domain-containing protein 2A
- Jouberin
- Transmembrane protein 216
Sequence:
MMAQSNMFTVADVLSQDELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW
Protein: Golgi-associated olfactory signaling regulator (Golgi protein in olfactory neurons) (Goofy) (J3KML8)
Organism: Mus musculus (Mouse)
Function: Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:23926254}; Single-pass type I membrane protein {ECO:0000269|PubMed:23926254}.
Interaction partners:
- Vomeronasal type-1 receptor
Sequence:
MQPFSPIFFHLLFLLNGLSSRAAPSPGQPVVADLQGMLQPSGMPTGTLENLTRDQPTPGSSASHPPEHSETPPSASPHISTKILRETPSPSPFLSLETPIPDQLTSVAESQGTSQMSPSRATLGKPSETPKPDPTGISPSDSPETPKPNPSNTSPPESPESVYTDPTPTLHHESPEISKRDTPKLSPGEESKIPSPRPTQFLSSKSLETYDPSATRHLNSALEPTTHPDPTESPQSVFLTTHNSNPTVVPQTQFPTSPSQNVTETARTSDLEPSSSLPTQPTTFREEATTPSEPGLSPSPEAPAVTRVATPGLSTSDSPGTKELHVPQNSDPKGPDIPLPSARIAGPPAPLEHPNQVAPAPQRHSRGDTVNTIIVVERVKETGVTLVSRPRGSVGGALCLFFAGTGLLIGIFLLLWCLYRRASRHRSFAHHRLRDSGDEPVLHLDAPKDPLDLYFYAPDAWVPSHIATQPPPSTPPLPPKLPPPPRGPQRLEALSPAALSPNFF
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1) (P10686)
Organism: Rattus norvegicus (Rat)
Function: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).
Subcellular location: Cell projection, lamellipodium {ECO:0000250|UniProtKB:P19174}. Cell projection, ruffle {ECO:0000250|UniProtKB:P19174}. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. {ECO:0000250|UniProtKB:P19174}.
Interaction partners:
- Linker for activation of T-cells family member 1
- Lymphocyte cytosolic protein 2
- Platelet-derived growth factor receptor beta
- Growth factor receptor-bound protein 2
- Proto-oncogene vav
- Fibroblast growth factor receptor
- High affinity nerve growth factor receptor
- Receptor protein-tyrosine kinase
- BDNF/NT-3 growth factors receptor
- Tyrosine-protein kinase
Sequence:
MAGVGTPCANGCGPSAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDFEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNTLRTGERPELCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVTFLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASGSTELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERASDASSQLFHVRAREGSFEARYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
Protein: T3SS secreted effector NleA/EspI homolog (B7UR60)
Organism: Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Interaction partners:
Sequence:
MNIQPIVTSGITTQNNRHHHAEQTSPTQIPQSELPNGCETGFVVHIPEDMQRHAPECGETTALLSLIKDEGLLSGLDKYLAPHLEEGSAGKKALDMFGLFNVSQMALEIPSTVPGISGKYGVQLNIVKPDIHPTSGNYFLQIFPLHDEIGINFKDLPGPLKNALSNSNIPTTVSTAASTIASATTSTVTTASKDPIPWFGLTAQVVRNHGVELPIVKTENGWKLVGETPLTPDGPKANYTEEWVIRPGEADFKYGASPLQATLGLEFGAHFKWDLDNPNTKYAVLTNAAANALGAVGGFAVSRFTGTDPMLSPHIGAMVGQAAGHAIQYNTPGLKPDTILWWAGTTLGLADLNKAEFGEARFTDYPRIWWHAREGAIFPNKADIEHATGADIRAMEEGVSVGQRHPNPEDVVINIESNNSPHHNPSNYVDTVDIIQETRV
Protein: Uncharacterized protein (Q57WH9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYDPAVPNNYRDVKIVQWKRAREVEENEKLSRTSMESILATPSPFDFPGMVQPPSPTPTDTSFPGSSEVLPLHLSVEELHQRRVRQSAALGITTAIRLERDELEAAHKVKVATGMDRKGRIGSKLEKFMKMATSSSSSGDAASGSNGDADVSSGMSSMGLPPSSLAGSSAPLVFQRSTLAAGGYMVKEDTNAQDGRKAPSGKPSSTILIRFIRDGPPPDLFEEDATAGGDNEGGAVGSLRAAGLAFLENVQGQCARYGIVRSVRPALLTEEQRTAVRARLEQCASTPVEVELRFARELVRVLVRFDTVAGAFKAIDALQQNCVNWSVCFFPTILFDAGTLGPSDGEPLCGT
Protein: Receptor protein-tyrosine kinase CEPR2 (EC 2.7.10.1) (Protein C-TERMINALLY ENCODED PEPTIDE RECEPTOR 2) (Q9C7T7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor kinase involved in the perception of C-terminally encoded plant signaling peptide (CEP) and subsequent regulation of root and shoot development. Together with CEPR1, mediates systemic nitrogen (N)-demand signaling upon the perception of root-derived peptides (e.g. CEP1) via the up-regulation of genes involved in N uptake and assimilation pathways.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Precursor of CEP1
- Precursor of CEP5
- Ubiquitin-conjugating enzyme E2 34
- High-affinity nitrate transporter 2.1
- Probable ubiquitin-conjugating enzyme E2 33
Sequence:
MSRRPDLLRGSVVATVAATFLLFIFPPNVESTVEKQALFRFKNRLDDSHNILQSWKPSDSPCVFRGITCDPLSGEVIGISLGNVNLSGTISPSISALTKLSTLSLPSNFISGRIPPEIVNCKNLKVLNLTSNRLSGTIPNLSPLKSLEILDISGNFLNGEFQSWIGNMNQLVSLGLGNNHYEEGIIPESIGGLKKLTWLFLARSNLTGKIPNSIFDLNALDTFDIANNAISDDFPILISRLVNLTKIELFNNSLTGKIPPEIKNLTRLREFDISSNQLSGVLPEELGVLKELRVFHCHENNFTGEFPSGFGDLSHLTSLSIYRNNFSGEFPVNIGRFSPLDTVDISENEFTGPFPRFLCQNKKLQFLLALQNEFSGEIPRSYGECKSLLRLRINNNRLSGQVVEGFWSLPLAKMIDLSDNELTGEVSPQIGLSTELSQLILQNNRFSGKIPRELGRLTNIERIYLSNNNLSGEIPMEVGDLKELSSLHLENNSLTGFIPKELKNCVKLVDLNLAKNFLTGEIPNSLSQIASLNSLDFSGNRLTGEIPASLVKLKLSFIDLSGNQLSGRIPPDLLAVGGSTAFSRNEKLCVDKENAKTNQNLGLSICSGYQNVKRNSSLDGTLLFLALAIVVVVLVSGLFALRYRVVKIRELDSENRDINKADAKWKIASFHQMELDVDEICRLDEDHVIGSGSAGKVYRVDLKKGGGTVAVKWLKRGGGEEGDGTEVSVAEMEILGKIRHRNVLKLYACLVGRGSRYLVFEFMENGNLYQALGNNIKGGLPELDWLKRYKIAVGAAKGIAYLHHDCCPPIIHRDIKSSNILLDGDYESKIADFGVAKVADKGYEWSCVAGTHGYMAPELAYSFKATEKSDVYSFGVVLLELVTGLRPMEDEFGEGKDIVDYVYSQIQQDPRNLQNVLDKQVLSTYIEESMIRVLKMGLLCTTKLPNLRPSMREVVRKLDDADPCVSNSQDTTGKITV
Protein: Uncharacterized protein (Q381R7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAKKHRVKRQKQVEYLLRLERERDEYLAKRKRAKRDRRERNEGELFGEALDNLAGGDVKRERKEVGISASEGKRAEESTKTVSTDSNTKLGSRPDAASVEQSKVKHLRKKY
Protein: Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) (Q05546)
Organism: Rattus norvegicus (Rat)
Function: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Aggrecan core protein
- Integrin alpha-9
- Integrin beta-1
- Integrin alpha-8
- Integrin beta-6
- Syndecan-4
- Tenascin
- Tenascin-N
- Syndecan-1
- Aa1018
Sequence:
MGIEGETVVLKNMLIGVNLILLGSMLKPSECRLEVTTERVQRQTVEEEGGASSYNTSSKEQPMVFNHVYNINVPLESLCSSGLEASAEQDVSAEDDTLAEYTGQTSDHESQVTFTHKINLPKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNTNCCQESAATGQLDYVPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGQCANGTCLCQEGYAGEDCSQRRCLNACSGRGHCQEGLCICEEGYQGPDCSAVTPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQPSLGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFTPKNNEGGVIAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQARGPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESDASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEYKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSPPVAPFDYYEYPIDHPSGRLDSSVVPNTVTEFTITRLYPASQYEISLNSVRGREESERICTLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVIVLTHFAMAGETILVDGVSEEFQLVDLLPRTHYTVTMYATSGPLVSGTIATNFSTLLDPPANLTASEVTRQSALISWQPPRAAIENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTIFTTGGRVFSHPQDCAQHLMNGDTLSGVYTIFLNGELSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLDNYHRITAQGRYELRVDMRDGQEAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYIHRLTAGRKRRALKF
Protein: Cytochrome P450 3A25 (EC 1.14.14.1) (CYPIIIA25) (O09158)
Organism: Mus musculus (Mouse)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- UDP-glucuronosyltransferase 2A3
- Cytochrome P450 3A11
- UDP-glucuronosyltransferase 2B17
- Cytochrome P450 1A2
- UDP-glucuronosyltransferase
- Retinol dehydrogenase 7
- Cytochrome P450 2C50
- Cytochrome P450 2C37
- UDP-glucuronosyltransferase
- Cytochrome P450 2E1
Sequence:
MELIPNLSIETWVLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGMWKFDEDCYKKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRMKKERLASNQKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKAPVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISREPIFQPEKPIILKVVSRDKPRTGS
Protein: Regulator of nonsense transcripts UPF2 (Nonsense mRNA reducing factor UPF2) (Up-frameshift suppressor 2 homolog) (AtUpf2) (F4IUX6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Recruited by UPF3 associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA (By similarity). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Required for plant development and adaptation to environmental stresses, including plant defense and response to wounding.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:19602621}. Cytoplasm {ECO:0000269|PubMed:19602621}. Cytoplasm, perinuclear region {ECO:0000250}.
Interaction partners:
- Regulator of nonsense transcripts 1 homolog
- RNA-binding protein Y14
- Regulator of nonsense transcripts UPF3
- Protein mago nashi homolog
- Eukaryotic initiation factor 4A-III homolog
- At2g29210/F16P2.41
- Nonsense-mediated mRNA decay factor SMG7
- Nuclear cap-binding protein subunit 1
- Polyadenylate-binding protein 1
- Polyadenylate-binding protein 2
Sequence:
MDHPEDESHSEKQDDEEALARLEEIKKSIEAKLTLRQNNLNPERPDSAYLRTLDSSIKRNTAVIKKLKQINEEQREGLMDDLRGVNLSKFVSEAVTAICEAKLKSSDIQAAVQICSLLHQRYKEFSASLTQGLLKVFFPGKSAEDLEADKNSKAMKKRSTLKLLLELYYVGVIEDSNIFINIIKDLTSVEQLKDRDTTQTNLTLLTSFARQGRIFLGLPISGQDEDFFKGLDVTADQKKSFKKAFNTYYDALADLLQSEHKLLLQMEKENAKLVNAKGELSEDSASSYEKLRKSYDHLYRNISSLAEALDMQPPVMPEDGTTRLTAGDEASPSGTVKDTSVPEPIWDDEDTKTFYECLPDLRAFVPAVLLGEAEPKSNEQSAKAKEKLSESSSEVVENQQTTEDTTEVSADSASMDDRSNAEQPKEKEEVEKEKAKDTKKEKGKEKDSEKKMEHEKEKGKSLDVANFERLLQRLPGCVSRDLIDQLTVEYCYLNSKTNRKKLVKALFNVPRTSLELLAYYSRMVATLASCMKDIPSMLVQMLEDEFNSLVHKKDQMNIETKIRNIRFIGELCKFKIVPAGLVFSCLKACLDEFTHHNIDVACNLLETCGRFLYRSPETTLRMTNMLDILMRLKNVKNLDPRQSTLVENAYYLCKPPERSARISKVRPPLHQYVRKLLFSDLDKDSIANVLKQLRKLPWSECEQYILKCFMKVHKGKYGQIHLIASLTSGLSRHHDEFVVAVVDEVLEEIRVGLELNEYGAQQKRLAHMRFLGELYNYEHVDSSVIFETLYLTLLYGHDTSEQEVLDPPEDFFRVRMVIILLETCGHYFDRGSSKKRLDQFLIHFQRYILSKGHLPLDIEFDLQDLFANLRPNMTRYSTIDEVNAAILQLEEREHASSGDKVSIERHSDTKPSNKSSSDVISSNGKSTAKDIRENGEAHGEESDSDSGSGSVVRDGQNEELDDGNHERGSESGDGDDYDDGDGPGSDDDKFRVRQKVVTVDLEEQADFDQELKALLQESMEQRKLELRGRPALNMTIPMSVFEGSGKDHHHFGRVVGENGEEVLDEENGEQREVQVKVLVKRGNKQQTRQMLIPSDCALVQSTKQKEAAELEEKQDIKRLVLEYNERDEEEANGLGTQILNWTSGGSRGSTRTGEGSGKSGGSRHRFYYHQGGGGSYHARRK
Protein: Rifin (Q8IHM1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKIHYTNILLFPLKLNILVYNQRNYYITPPHIQTNRSLCECELYAPANYDSDPEMKRVMQKFHDRTTQRFQEYDERLQEKRQICKDKCDKEIQKIILKDKLEKELMDKFSTLDTDIQSDAIPTCICEKSLADKVEKGCLRCAQNLGGVAPGWGLLSGFGYVTWSQYISGIAAKAAADAGLKAGVKVGLVNAVKIVTNTLIESGGEIPIMDWEKLIIFGDFSDGVTLHAIFKNLNNMMNCHLDSGKYSQFSMFVQKFAKNFKPITANYSKEVAEVTKAVADAKTGVLTKAGNATSSLSTGITASIIAIVVIVLIMVIIYLVLRYRRKKKMKKKLQYIKLLEE
Protein: ORF 11 (ORF11) (O40917)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MAQESEQCSRAFAVCSSKRQLGRGEPVWDSVIHPSHIVISNRVPLLLREQHICLPSCPSVGQILHRAYPNFTFDNTHRKQQTETYTAFYAFGDQNNKVRILPTVVESSSSVLIFRLRASVSANIAVGGLKIIILALTLVHAQGVYLRCGKDLSTPHCAPAIVQREVLSSGFEPQFTVTGIPVTSSNLNQCYFLVRKPKSRLAKPFARLSAETTEECRVRSIRLGKTHLRISVTAPAQETPVWGLVTTSFSLTPTAPLAFDRNPYNHETFACNARHYIPVIYSGPKITLAPRGRQVVWHNNSYTSSLPCKVTAIVSNHCCNCDIFLEDSEWRPNKPAPLKLVNTSDHPVILEPDTHIGNALFIIAPKARGLRRLTRLTTKTIELPGGVKIDSRKLQTFRKMYVATGRS
Protein: Verprolin 1, isoform E (Q7KVL6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRLKRSSKQKMAIPPPPGPPPPPGPPPPPAMGGLKLGGAGGADARSALLSSIQKGTKLKKTTTVDKSGPALSGKVCGGDGGAGIGAKRTLNNNTSTSNHNNSSSSSNGLGNGTPKLGGLFEGLSQMPKLKPVNGIRATPSAGSAATTTSKSTTNSSAQQRSNSPPAATSASNASNGPMDFNTELTKHLTLKRQKQQQQQQPQPPTNNTHINATEANLRTNRGPPPQPPKSANSNDSILERMNIPRTAPTPPFGNSSSVKAASPTLSDSGSNSSGSGGGSGSVKSKAANLNISLGNSFVNSSKSTVSASTASLNSSLTSSTGSVRNLAPNKSTLFGGSSGSSSGSSSGGGYASVHKSSPPSTADSTPSVTPTPPPLQLPMKPAISFGKPNFAPKPPGLNQLAMANGQQRPAVTRHHSMKSPRSPPAAGIVNGLVFPTQQHLGTLRGPLQFHGSESSSPNTSAGSMRCAPNPPKSRPSVKPPPPPTPARSFSNTNLNNIGGSTMFSAVNTALIQSSAISSQAPSPPITQPPSSSSSSNSVAALRDQFRGGAGMSNGAPSPPLPPTPAPSSNPSSASASPKSLLRDNVKPIILNGGPLNPPAPPPHRSCPPPPPPQRQSSNQDRVKYWIDKTVYSFKKILHINRQGRHSGESVKVINMLNSKRNGGSGSGSAPVPPQRHSSIRPNAPSTPPTHMANASHQFGSSSGLSSGSGAGAAASVGRLVNDLETKFGKRFHNVTEFPKPPPFLNIQKVYPSRTFKATNGM
Protein: Leptin receptor (H0ZIF9)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Tyrosine-protein kinase
- Suppressor of cytokine signaling 3
Sequence:
MCWQIIPTMFVLMEFLQMAAAHCMVLPVPPRNFTLPCVLLNETFLSPFSAGSWSGLRRELGAPKIKPLMNEENFLCCLWSASNIDCSLYRASMQARKFIPSEINLSAPQKIDWTWNMECWIRGKLDLLVCNLQLLKMDLRTDLKVNLLYSGSELSLGAASTSSLQGTVRVAPCDCGDQATCQCLVATPSLNHTYLLWLEVVAGGTALGSPPMALQPTDIVKPEAPVKLRLELAERGQVKLCWSSPAPLPFPLQHQVRISAPPGHGDSQMLQVALENSVAMDNALLDSPSSVQVRSRNLHGPGFWSDWSTPYNLTLGAPVLYFPARSLSSAGSNISFLCLYKNHTQAVAARELVWWLNLAEQIPASQYSLLSSRVSKVTLFNLRATQPRGGFFYNALYCCHQSGECHHRYAEFYIVDMDFNISCETDGYLTKMTCRWSANPTTLLLGSLQLRYHRSQIYCSDFPSPSPNSEVKECHLQRNHSYECTFQPIFLLSGYTLWIEFKHFLGTLQSSPTCVIPADVVKPLPPSNVGAELTRNTGLLNVSWTQPVFASRDLTFQIRWNSGSREDIPWQLYEVPNPAGSWAVIPVEQLCVQYVVQVRCRELDGSGYWSDWSRAAQTLVQDIRAPLQGPEFWRIVSEDPARKQRNVTLLWKPLTQNHSLCSVSRYIIKHQTPGNTSWEEFVDHGTSWTFPWMEPTHTVTILAMNSVGISAINSNLTLSQQMSTVDAVQSLSAYLVNSTCVVVVWSLSPQIPGIKSFVIEWRNLNREEQMKWLRVPSNLRKYFIYDHFILIEKYQFSIYPVFDGGVGKARATDQFAKGGFETGNTGSLHVVLPIVFSTSVLLLGALLVSHQRMKKLLWEDVPNPKNCSWAQGVNFQQPETLEHLFAKHPEPVSCEPLLLEAEMVLEDISITKTLGKEEPGDFLGIDSTSPAPQDSEWDSACSSSHFQSSSSCRSCQDGEAPAEGDLRYATVVSSCAPSGLCRRKPGPRRCWDSCCFLGEHPTVVGAFSSSAWEVGSGALLVLPGSQPSRALSLVSSEGFSEPSDEAFPGSTERSLCYLGITALEKGHRDVLLTVSSRGTCQLQSRDLLTEGELLQHIPSSVKEFIQSSLRPKGTVPYVPQFGVAAAKGQEATEKK
Protein: Mitofissin (Autophagy-related protein 44) (Mitochondrial fission factor ATG44) (Q2V2P4)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:37192628}. Vacuole {ECO:0000269|PubMed:26928762}.
Interaction partners:
- ERMES regulator 1
- SERF-like protein YDL085C-A
- Cx9C motif-containing protein 4
- RDS3 complex subunit 10
Sequence:
MTLVGKLVHISIDLVLVSTCLAGIKRNTGLTPKLETLDNQTMRNYMKRYLNLGESVYDYSVATCGSSTYFARK
Protein: Nuclear RNA export factor 5 (TAP-like protein 1) (TAPL-1) (Q9H1B4)
Organism: Homo sapiens (Human)
Function: Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.
Subcellular location: Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclear rim.
Interaction partners:
- NTF2-related export protein 1
- NTF2-related export protein 2
- mRNA export factor RAE1
- THO complex subunit 4
- THO complex subunit 5
- Eukaryotic initiation factor 4A-III
- Regulator of nonsense transcripts 3B
- Regulator of nonsense transcripts 3A
- Nucleoporin NUP42
- Nuclear transport factor 2
Sequence:
MRRNTQDENMRKWFKVTIPYGIKYDKAWLMNSIQSNCSVPFTPVDFHYIRNRACFFVQVASAASALKDVSYKIYDDENQKICIFVSHFTAPYSVKNKLKPGQMEMLKLTMNKRYNVSQQALDLQNLRFDPDLMGRDIDIILNRRNCMAATLKITERNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKTLNLSKNKLESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQSNLCKYFKDSRNIKILKDPYLQRKLLKHTKCPRNVDSLSALPETQHDFTSILVDMWYQTVNTCFLPRAGPESQRWWCLLSLKWKDGLRVLILPSCGPSSLPLAAIPVCAS
Protein: Uncharacterized protein (Q38E40)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKQSKLVSRPSKTKKPKERKDRREDERYQREMDALIAREVARENVSMRSDTHKPQPKLLEEVQKDTSRRPKTPTSLSTAAVEKQAKIDKESGFQPVVNQRKERQQQQHQQQQTSAPKPMLVNEALERKLNHFFSNLNRKEKLTRLSQPEENPTASKGATIIVRKDIANARSWQQQQQ