wanglab/gogpt-training-data huggingface dataset:
Protein: Unconventional myosin-Vb (Myosin heavy chain myr 6) (P70569)
Organism: Rattus norvegicus (Rat)
Function: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1469047}.
Interaction partners:
- Rab11 family-interacting protein 2
- Ras-related protein Rab-11A
- Ras-related protein Rab-8A
- Exocyst complex component 6
- Optineurin
- RAB25, member RAS oncogene family
- Ras-related protein Rab-10
- Ras-related protein Rab-27A
- Ras-related protein Rab-11B
Sequence:
MTYSELYSRYTRVWIPDPDEVWRSAELTKDYKDGDESLQLRLEDDTILDYPIDVQNNQVPFLRNPDILVGENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRESHQISIFKIIASILHLGSVEIQAERDGDSCSISPQDEHLSNFCRLLGIEHSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARNALAKHIYAQLFSWIVEHINKALQTSLKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYERHSNSQHFQKPRMSNTAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFRDDEDSVPATNTAKSRSSSKINVRSSRPLMKAPNKEHKKSVGYQFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLMKKRELANTTDKKNICKSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATIMIQKTVRGWLQRVKYRRLRAATLTLQRFCRGYLARRLTEHLRRTRAAIVFQKQYRMLKARRAYCRVRRAAVIIQSYTRGHVCTQKLPPVLTEHKATIIQKYARGWMARRHFQRQRDAAIVIQCAFRRLKARQALKALKIEARSAEHLKRLNVGMENKVVQLQRKIDDQNKEFKTLSEQLSAVTSTHAMEVEKLKKELARYQQNQEADPSLQLQEEVQSLRTELQKAHSERRVLEDAHNRENGELRKRVADLEHENALLKDEKEHLNHQILRQSKAESSQSSVEENLLIKKELEEERSRYQNLVKEYSQLEQRYENLRDEQQTPGHRKNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGIEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKEQQDSKKVQVEQQNNGLDVDQDADIAYNSLKRQELESENKKLKNDLNERWKAVADQAMQDNSTHSSPDSYSLLLNQLKLANEELEVRKEEVLILRTQIMNADQRRLSGKNMEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNSQTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQNLKHEEEVEHLKAQVEAMKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDFKELVEKLEKNEKKLKKQLKIYMKKVQDLEAAQALAQSDRRHHELTRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLSSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVRPTGYRKRSSSMVDGENSYCLEAIIRQMNFFHTVLCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDACSWSTGMQLRYNISQLEEWLRGKNLQQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNGFEERVTVSFIRTIQAQLQERSDPQQLLLDSKHMFPVLFPFNPSALTMDSIHIPACLNLEFLNEV
Protein: 60S ribosomal protein L29 (Q6FVV8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- 60S ribosomal protein L36
- L23
- Small ribosomal subunit protein eS6
- Candida glabrata strain CBS138 chromosome M complete sequence
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS5
- 60S acidic ribosomal protein P0
- L21
- 40S ribosomal protein S8
- Small ribosomal subunit protein eS21
Sequence:
MAKSKNHTAHNQTRKAHRNGIKKPKTYKYPSLKGVDPKFRRNHRHALRGTAKTLAAAKK
Protein: Chromosome 6 open reading frame 142 isoform 6 (A0A0S2Z5Z3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MCSWYLGFECSVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIPEESSDKSPETVNRSKSNDYLTLNAGSQQERDQAKLTCPSEVSGTILQEREFEANKLQGMQQSDLFKAEYVLIVDSEGEDEAASRKVEQGPPGGIGTAAVRPKSLAISSSLVSDVVRPKTQGTDLKTSSHPEMLHGMAPQQKHGQALDEPAKTESVSKDNTLEPPVETPTTLPRAAGRETKYANLSSPSSTVSESQLTKPGVIRPVPVKSRILLKKEEEVYEPNPFSKYLEDNSDLFSEQLSHPMVAIPEHEALDSKEQ
Protein: Phospholipase A2 acanmyotoxin-1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (P85062)
Organism: Acanthophis rugosus (Irian Jayan death adder)
Function: Snake venom phospholipase A2 (PLA2) that has myotoxic activity but no significant neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Subcellular location: Secreted {ECO:0000269|PubMed:12540524}.
Interaction partners:
Sequence:
NLLQIGIMKRCANKRRRPVFHYRDYGCYC
Protein: Oxysterol-binding protein homolog C23B6.01c (Q9UUA1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized protein C691.05c
- Uncharacterized protein PYUK71.03c
- Vesicle-associated membrane protein-associated protein scs22
- Uncharacterized protein C962.01
- Vesicle-associated membrane protein-associated protein scs2
- Phosphatidylinositol 4-kinase pik1
Sequence:
MPHEKQDRDAEEIEDEGKNIILGIVSQLRPNMDLSKVTFPTFVLEPKSMLERITNFMSHPDLLLNVQKTADPEMRFLDVVRFYMSGWHIRPRGVKKPLNPILGETFTGFWKFPPSNSKDPNLQKLHGIAVYAAEQVCHHPPISAYFYLCPEYKVRIDGVVKPRSRFLGNSAASIMEGIASIKLQDLDEEYLITQPNVYARGILFGKMRLELGDHVTVRCPKTDLQADIEFKVKGFISGTYNSIAGKVKRVSTGEVLYKISGKWDSEMSVESVKTGETRPLLDVSKHDVYLVSARPLEEQGERESQRLWYKTCQAVIARDQTTATETKSAIEDRQREEAKQREIENVQWKPKYFKMIAPEEYILNFDIPNGKSDLEVLCALDEFIPIFSEVDRIAFHKFLSENTKPEDSSIHKHSRDASGDSTKGFAEHMPAPARRRRPQSTASFVTYRSDNGSVDEYHDAQLPDPNTLSKLHEEQDPAL
Protein: Protein NODULATION SIGNALING PATHWAY 1 (OsNSP1) (GRAS family protein 14) (OsGRAS-14) (Q84MQ9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor involved in the control of strigolactone biosynthesis in roots through the activation of the beta-carotene isomerase D27, which participates in a pathway leading to biosynthesis of strigolactones.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MSYHEEERHGGNGLDWFEESMSSLLAADVDLAGGGGDAGGGGYAWWWAASPAAQQDDIGSVVAQTLSPPSTAAPAAASPSIASPAASSPSDVPSSSSKKRKSPAHRAPGHTGGKKGGGGKGGGGGSDRDMRWAEQLLNPCAVAVEAGNLSRVQHLFYVLGELESFSGDANHRLAAHGLRALARWLPAAVGPAAAAAVRVPPCSERPTTAFAAAEPRLFRASLIRFHEVSPWFALPNALANAAIAQASTCGAAGATPRPLHVVDLGVSHGVQWPTLLESLTRQPGGRAPPSVRLTVVGPGATATSPVAPFSASPPGYDFSPHLLRYAKSINLDLRISRAATLDDAVPGDDGEALVVCLQFRLGHAAAEERREVLRKARGLNPELVVLSELDSGVGVVGGDGGSAAGEFAARLELLWRFLESTSAAFKGKDVEERRLLEAEAGAILAAADVAAAGEGREGWRERMAAAGFEEAPFGAEAVESARSLLRKYDSGWEMSAPSPAAAAVALRWKGQPVSFCSLWRPAA
Protein: Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] (P07602)
Organism: Homo sapiens (Human)
Function: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
Subcellular location: Lysosome {ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:21835174, ECO:0000269|PubMed:22431521}.; SUBCELLULAR LOCATION: [Prosaposin]: Secreted {ECO:0000250|UniProtKB:Q61207}. Note=Secreted as a fully glycosylated 70 kDa protein composed of complex glycans. {ECO:0000250|UniProtKB:Q61207}.
Interaction partners:
- Lysosomal acid glucosylceramidase
- Prosaposin receptor GPR37
- G-protein coupled receptor 37-like 1
- Galactocerebrosidase
- Acid ceramidase
- Arylsulfatase A
- Proactivator polypeptide-like 1
- Progranulin
- Transcription factor Jun
- Lysosome-associated membrane glycoprotein 1
Sequence:
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
Protein: Transducin family protein / WD-40 repeat family protein (F4K7D1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serine/threonine-protein kinase VPS15
- Prohibitin-7, mitochondrial
- Prohibitin-2, mitochondrial
- Prohibitin-1, mitochondrial
- MICOS complex subunit MIC60, mitochondrial
- Prohibitin-6, mitochondrial
- At4g33625
Sequence:
MTQSICSSSQDQSSSPRSLITPRKSATKFHRRRGRSVFNMLVQREMSPKAKFVPRKRWGKSRWYTDSSCGTNNESMKETGQSLTSWVEAESLQHLSAKYCPLGAPPRSTIAAAFSTDGRTLASTHGDHTVKIIDCETGNCLKVLTGHRRTPWVVNNSISDSEMNFAHTFGICSVGWLVRFHPHHSEIVASGSLDLEVRLWNTTTSECIRSHLFYRPIASIAFHAEGELLAVASGHKLHMWHYNRRGEGSSPTVVLKTRRSLRAVHFHPHGAPLLLTAEWQVNEIDSLDSSMSRATSMGYLRYPPPAILFTSTESNQTSLAAENENRTSSPPLPLATSSGPSGPNSVPGNSPSNIFLTRAGDRTSPAVDGMDVDEAQPVGRNGIPSQVSNRSDFPELGQIRQLFHFRDRVSWELPFLQGWLMAQGHGVANPVVTPTGSSNHGISAPSSTASLEAAVALLEIPSGVNLHAVSRRGGAQEQTSQPQFSRTGLPEGVSSRNTQHGSDAQPVVNRVQSELATSIAASAAAAAAAELPCTVKLRMWSHDIKDPYAQLKSDRCLFTIPHAVLCSEMGAHYSPCGRYLAACVACVFPHGEIDPGLQTQAQQDSGLATSPTRHPVTAHQVIYELRVYSLQKESFGSVLVSRAIRAAHCLTSIQFSPTSEHILLAYGRRHGSLLRSIVSDGETTSHFFTVLEIYRVSDMELVRVLPSSEDEVNVACFHPSPGGGLVYGTKEGKLRIFQYNTAATSNFTGPNT
Protein: SD07362p (Q8T8Q2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MNNTSMVYKYWYAMMATTCIRFKYYHAWLLADAICNNSGLGFTGYDKDGNSKWDLISNINVLSFEFSTNMRDAINNWNCGTNRWLRTLVYERVPQQYGTLLTFALSAVWHGFYPGYYLTFATGAVVVTAARTGRRLFRHRFQSTQVTRMFYDILTCLITRVVLGYATFPFVLLEFMGSIKLYLRFYLCLHIISLVTIFILPKFIRGERRLRTSNGNGNVRLSGSGNTKDAVTTSVESTAALTAGNDLNEDKEEDKHAQCKVHTPTQQQPAAGPHKTTVEQPTEQPNNVNLRSRPQQQQPHLEKKAMPPTCARDAVSVPHDQCEMDQLSSKLKEKIEAETKNIEEFIDKTVTETVSGIVEFKNDLMRDIEFPKLKLPGSNGAISLDSSNGGGLRKRTISSVHDNGTDPGHATADLHPPLEENGAAFLKKEIEVINAVVQQAVPAVLSNGHAK
Protein: 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha (EC 1.14.12.19) (P0ABR5)
Organism: Escherichia coli (strain K12)
Function: Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.
Interaction partners:
- 3-phenylpropionate/cinnamic acid dioxygenase subunit beta
- 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit
- 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD
- 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenasepropanoate dehydrogenase)
- Flavodoxin/ferredoxin--NADP reductase
- Hca operon transcriptional activator HcaR
- 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
- 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase
- 2-keto-4-pentenoate hydratase
- Carnitine monooxygenase reductase subunit
Sequence:
MTTPSDLNIYQLIDTQNGRVTPRIYTDPDIYQLELERIFGRCWLFLAHESQIPKPGDFFNTYMGEDAVVVVRQKDGSIKAFLNQCRHRAMRVSYADCGNTRAFTCPYHGWSYGINGELIDVPLEPRAYPQGLCKSHWGLNEVPCVESYKGLIFGNWDTSAPGLRDYLGDIAWYLDGMLDRREGGTEIVGGVQKWVINCNWKFPAEQFASDQYHALFSHASAVQVLGAKDDGSDKRLGDGQTARPVWETAKDALQFGQDGHGSGFFFTEKPDANVWVDGAVSSYYRETYAEAEQRLGEVRALRLAGHNNIFPTLSWLNGTATLRVWHPRGPDQVEVWAFCITDKAASDEVKAAFENSATRAFGPAGFLEQDDSENWCEIQKLLKGHRARNSKLCLEMGLGQEKRRDDGIPGITNYIFSETAARGMYQRWADLLSSESWQEVLDKTAAYQQEVMK
Protein: Receptor protein-tyrosine kinase (EC 2.7.10.1) (Q9QX70)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MRPSGTARTKLLLLLAALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAVLSNYGTNKTGLRELPMRNLQEILIGAVRFSNNPILCNMETIQWRDIVQDVFLSNMSMDVQRHLTGCPKCDPSCPNGSCWGRGEENCQKLTKIICAQQCSRRCRGRSPSDCCHNQCAAGCTGPRESDCLVCHRFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGVSKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPENWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKATNHVCNPLCSSEGCWGPEPTDCVSCQNVSRGRECVDKCNILEGEPREFVENSECIQCHPECLPQTMNITCTGRGPDNCIKCAHYVDGPHCVKTCPSGIMGENNTLVWKFADANNVCHLCHANCTYGCAGPGLKGCQQPEGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRQLVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMEEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSANSNSSTVACINRNGSCRVKEDAFLQRYSSDPTSVLTEDNIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVSNPEYLNTAQPTCLSSGFDSSALWIQKGSHQMSLDNPDYQQDFFPKEAKPNGIFKGPTAENAEYLRVAPPSSEFSGA
Protein: Kinetoplast DNA-associated protein (Q57TX7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPPPHRDKAVVRINALAVLEDIQRTGWLIEEFRRLKKEGGSRVELNGLKEEIHRLREAQKAFLGNHDRTCAAAAEEPISSSKRKRDTKTTTAQQPHRSSSHDVQTETTQPTLRAYTGCQLGPGFVSEQHPIAGTRSSKEYQKRGDSVTRPPTSLLSDDYETRKHSSAMFAVVLAEAHTRREIVHKYEKKRLIIAASFREEKILVLLSAQHVSAHLHHQPTSAGKVSGPHGLQQADKARESVQLSQQSNKLFTDPWCPPRSTGIGNNLETSHCFSSSIIQDAQKKVIHEQRHNKYDEQAHKHYKKSNNHNNINTEAPSAFNTISLITRQPAAERTTITRHTQSIQNTNPAPTENKATQTLAIQAKETHEPTKHFEEKSYSSKTQSQNFSDRTEIERKQTHTTSRIETNYPTAQHAYTKQKEITIHASQHAPSLEEEARLRAEEEARIRAEEEARIRAEEEARIKAEEEARIRAEEEARIRAEEEARIKAEEEARLRAEEEARLRAEEEARLRAEEEARVRAEEEARLRAEEEARIKAEEEARIKAEEEARLRTEEEARLRAEEEARVRAEEEARLRAEEEARIRAEEEARIRAEEEARIKAEEEARIRAEEEARLKAEEEARVRAEEEARLRAEEEARIRAEEEARIRAEEEARIKAEEEARIKAEEEARLRAEEEARLRAEEEARIKAEEEARIRAEEEARIKAEEEARIKAEEEARIKAEEEARIKAEEEARIKAEEEARVKAEEEAVTLLEGKEHIIDRVRALSDDIIRQSLNDAFSRHIASARAMEDARLEAEEEARLKAEEEARLKAEEEARLKAEEESRLKAEEEARLKAEEEARLKAEEEARLKAEEESRLKAEEEARFKAEEEARFKAEEEARLKAEEEARLKAEEEAVTLLEGKQHIIDRVRALSDDIIRQSLNDAFSRHIASARAMEDARLEAEEEARLKAEEEARLKAEEEARFKAEEEARLKAEEESRLKAEEEARLKAEEEARFKAEEEARVKAEEEAVTLLEGKEHIIDRVRALSDDIIRQSLNDAFSRHIASARAMEDARLEAEEEARFKAEEEARLKAEEEARLKAEEEARFKAEEEARVKAEEEARFKAEEEARVKAEEGAVTLLEGKEHIIDRVRALSDDIIRQSLNDAFSRHIASARAMEDARLEAEEEARFKAEEEARLKTEEEARVKAEEEARFKAEEEARLKAEEEARLKAEEEARLKAEEEARFKAEEEARFKAEEEARFKAEEEARVKAEEEAVTLLEGKEHIIDRVRALSDDIIRQSLNDAFSRHIASARAMEDARLEAEEEARVKAEEEARLKAEEEARLKAEEEARLKAEEEARFKAEEEARVKAEEEARFKAEEEARVKAEEGAVTLLEGKEHIIDRVRALSDDIIRQSLNDAFSRHIASARAMEDARLEAEEEARFKAEEEARFKAEEEARVKAEEEARFKAEEEARLKAEEEARFKAEEEARLKAEEEARFKAEEEARLKAEEEARVKAEEEAVTLLEGKEHIIDLVRALSDDIIRQSLNDAFSRHIASARAMEDARLEAEEEARLKAEEEARFKAEEEARLKTEEEARVKAEEEARLKAEEEARFKAEEEARLKAEEEAVTLLEGKEHIIDRVRALSDDIIRQSLNDAFSRHIASARAMEDARLEAEEEARLKAEEEARFKAEEEARLKAEEEARFKAEEEARLKAEEEARFKAEEEARLKAEEEARLKAEEEARFKAEEESRLKAEEDEQLGVDGEGAAVFGDKLFIIDCLRSLCVNLISECFEDATSVCCGGVCSFGCVVDDVAYSGELESVMSMSLLDTFRGGEACVGAAEAVTEYVLSSGISTVAMLINNDVCSSGTSEFYYGGSSTLYGSCALPSPDCGTQGTLSCVGELNGAGVASVDCVISGSSESPSIYSVVELSIAEGGANRLVEKQGEHSGTVTPSDPSLLYSAHAGNCEKRFTAFMVDSVINYLVEGAGTALEALAHPGLLSYSTIESTLSQSIISVAAAAMGEGGLSGEWRAGLSALAERLASDYITVASREKLQRLDEFVWYEEAFLSSEEALSRSAGLVSPQCLFGRLQPSDIRFLAYHYTELVRKGTNNAEDFYCEARLRENLFERNDGNGALSSSASASLLAVGGEDGLGNSGTQRSLGSPCYAGSRAGTLGMDSRRAGITQLVLGHALENLLEEMVGDAAKWVASLSEVR
Protein: Protein kinase dsk1 (EC 2.7.11.1) (Dis1-suppressing protein kinase) (P36616)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. Abundant expression accelerates the exit when cells are in M-phase and also delays the entry into mitosis when cells are in G2. Phosphorylates prp2 in vitro and so may have a role in co-ordinating pre-mRNA splicing with the progression of the cell division cycle.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8485317}. Nucleus {ECO:0000269|PubMed:8485317}. Note=Enriched in the nucleus in mitotically arrested mutant and wild-type mitotic cells but cytoplasmic enriched in cells at other cell-cycle stages.
Interaction partners:
- Pre-mRNA-splicing factor srp2
- Pre-mRNA-splicing factor cdc5
- Splicing factor U2AF 59 kDa subunit
- Pre-mRNA-splicing factor srp1
- RNA-binding protein rsd1
- Branchpoint-bridging protein
- Dual specificity protein kinase lkh1
- KRR1 small subunit processome component homolog
- Splicing factor U2AF 23 kDa subunit
- U1 small nuclear ribonucleoprotein 70 kDa homolog
Sequence:
MGSDGSSLSPKVSQPGHTEIVDHVSEKVITNGKNVNKKVNAEVDGKSMVEKVKTHEENAEDYHYGGYHPVYIGEEFHHRRYVVERKLGWGHFSTVWLAYDRAAKRRVALKVVRSAEHYRETSIDEIRILQKIREGDEKHLGKKHIISLLDYFVHRGPNGAHVCMVFEVLGENLLSLIQSYGHRGVPVGIVKQIAYQLLIALDYLHRECGIIHTDLKPENVLICIDQDALQHIEAPATTSSPTSNTSSSKTRNNTGYTAKAPIIKRGQSVDNSAQERKTFAKNPTKNSKPAGQVIPSSPFTSTLSRFPSLEGAVSEISLRDSQKHNSHPNSPFSSGDNSLILDGVNGSQEPVPKITVKIADLGNACWTRKHFTNDVQTRQYRSPEVILGCRWGASADCWSFACIIFELLTGDYLFDPRNGNSYSKEDDHIAQIIELLVNYPKQMALSGKHSRDLFNRRGELRNIHKLKFWPLKDVLEQKYHFSAELAQQISDFLSPMLCFDPAKRTNAGYMSNSPWLREVADPTFKIETTGATGEDVPGWATEIR
Protein: Synaptic defective enhancer 1 (Q95XQ1)
Organism: Caenorhabditis elegans
Function: Acts as a negative regulator of nuclear pre-mRNA 3'-end processing (mRNA polyadenylation) (Probable). Plays a role in tissue-specific expression of protein isoforms by regulating differential processing of pre-mRNA 3'-end (alternative polyadenylation). In neurons, regulates alternative polyadenylation of specific mRNAs including unc-44 and dlk-1 by interacting with phosphatase ssup-72 and thus preventing ssup-72 dephosphorylation of RNA polymerase II subunit ama-1. Specifically, alters the usage of internal polyadenylation sites (PAS) to promote the production of neuron-specific unc-44 isoform and dlk-1 isoform c, both required for normal synapse and axon development. Conversely, in the epidermis, by inhibiting ssup-72 function, promotes the usage of an internal PAS preventing the production of one of unc-44 isoforms. In neurons, also negatively regulates protein levels of pre-RNA processing protein psf-2.
Subcellular location: Nucleus {ECO:0000269|PubMed:28087624}. Nucleus speckle {ECO:0000269|PubMed:20530551}. Note=Also localizes to a small subnuclear ring in neurons. In neurons, partially co-localizes with pfs-2 in the nucleus. {ECO:0000269|PubMed:20530551}.
Interaction partners:
- RNA polymerase II subunit A C-terminal domain phosphatase ssup-72
- pre-mRNA 3' end processing protein pfs-2
- IBB domain-containing protein
- Death-associated protein kinase dapk-1
- Suppressor of forked domain-containing protein
Sequence:
MGEPSPSRRRSITSGIPCPSPTKQVLPPPPPEELHNILRKRPRSSAIPTTSQTHVRAPRKETDVVDRIWHDIDEEQREKLARRKEEAAKRKEQQPAQHIRDYLPLTATNLRNFRNEDSTISDFIHRQGMVDKLLGYKMLLGKMENCGTLGYEKMSEDEVQQLSREWLKNFFPSEQAHVGPRTPPSPAVDSDGGSYPKRPRRGPKTPPGSPGPSMDQAAVNRRELIEQLARNFGISSYKVEETLGTGLDKALEDCSKKLKNELMETFKDQLLSQIDRKTKIRDDLSDQMELVSDCSLSPDLIKKEEPDVVYHMAVPPPPIPPPIQPPPYSYYPVAPAAAPQVYHYAPPPPPPPPHPQQGLYQQNMMAYPPPMQHFNAPPPPMAPYQHQAPPSIVLPPVNVPPPPIGVRIDTPIPTAVLPIPTMVPPPPLPPPQAPFSGDCWRAQPAAPVPASVPVSSAPPPSVVVNVQSTLFSALGLHHKPPPPPPPPPPPTTSSTTTSHIPPPPPPPLPFSSAPPPPPPLPMVAAGPSPPSFVPPPPPPNPNQNPSIVLSPSAVTGGGGYRHRVNQFPPQQQQSFSNF
Protein: EG:115C2.6 protein (Histone H4 transcription factor, isoform A) (Histone H4 transcription factor, isoform B) (RE36568p) (O77260)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Homeobox protein goosecoid
- Lateral muscles scarcer, isoform B
Sequence:
MLRPQSSVPAPQPPGKRKKPAELELTCGWRDCQEICTGEWSLNGHIGDHLEHYAKAQDDRGAHAEHTEHQCTWNSCDFRTENQVEFERHSYYHGYYLNLLLQGKLECDLHPEIPACTAPARLMEKLPALGQNFRCGWTDCEREFVSIVEFQDHIVKHALFEYDIQKTPEDERPKTMCNWAMCHKHMGNKYRLIEHISTHSNKKQVACFHCGELFRTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKLLKSHVVRHVNCYKCTMCDMTCSSASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHSKTVHQCEHPDCHYSVRTYTQMRRHFLEVHGNNPILYACHCCERFFKSGKSLSAHLMKKHGFRLPSGHKRFTYRVDENGFYRLETTRLESLEVTQQILSPQVNDSLAKPGTGSCYEIVDPTNTEFERIIVSNDPNEAQLMGEVVISLPSLAEEL
Protein: Variant surface glycoprotein (VSG), putative (Q380U9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MTAVSNIIATFIGLVVATLLLSRGTQADPAAELTKQDTPCKSAHYLIKLAAAAEGKLKSLLEKTTEAVDEHRALEVYAATTDTGAANAAIAGLSEYASRRTATLAKAAVTCAQAVSQLTRTLNIEAGKNLALSSATEIKSATGTAQAMSNTGQGQSVSGHLKLDKLTDDSCAKTYTATAANTDNDPDTRQLESIRIHKLEGKTTADTAAGVCQVACVGAACSTAETNIKVSSAAATLFKAGELAQLAVKTTDAKPKRSDTPQGLKKELEKHQTSIEHRLYDFLKNKPCDADMASVRNMAVVQNDEGVRKAVLIELQGPAAKYDASSDSQKKAITDGIKAMFGGTETEFNAKIWEKVKANSVKQKIAGTDIDSKIEQLSTDTNRGLVLAYHASQRKNKPSCKTETSTQKPQQCGSQTTPEHCQKEGCYLDENKTPKCFPKKSKDDKKNGDYAKATNTTGSNSFVIHKAPLLIAVLLF
Protein: Ultrabithorax binding protein 1 (Q9NHW9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNRNRRAFAGNNKPFVFGGIYNPNATVKPLIQMPLQAANVQEQQSSPVGLYPTSASPVAVQSPQDAFLAVQSPGAPAPVQLANSSDQQNNPDADAIASKLPMPVIIKEEPISVNDEPSVDNIEDNTSASTSASGIGGKIPFKKIFQKRKKSSERTRDKKLRQNRQLRKSMLPKNALMALNEVKGVTISDFTIDSNTDGGFTAVVTVNSNQYEGKGTSKMTAKNAACEKAWRDFIIAKMTPKPPRIHQVEMGSEPMDINEDEADAPDDDLPMLNLASFAIYKLFAEWEREGYVVPEMHPSANAAQQAGGDAGTPVPPVPKEPKKPPVRTELPSGWETMHPATILCIMRPGLNYVDYGSSGDKTNGMQHLGIMVDNQEFHANGRSKKIARRNVAVKVCNSLFGTNFTYSDTT
Protein: At4g30630 (Q9M097)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g51500
- At5g57910
- Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein
- Transcription initiation factor TFIID subunit 14b
- RuvB-like protein 1
- Protein EIN6 ENHANCER
- Histone-lysine N-methyltransferase ATX4
- SWR1 complex subunit 2
- E3 ubiquitin-protein ligase JMJ24
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
Sequence:
MKKTNFVSSASGGDPMIRLTFVQVLELEKELEIKRKRLEMIKQKRLTLKSEVRFLRRRYEHLKQDQTLETSPEMLRLSESGGLEVPRKPSGERKKQSGVRASVPCFDLKLKNTICNEKEALANNVASCDLDKKRKRSRGSDVLTFPVSLPDLNGEGNTSGTDKVPGFDLNQISREEEEPEVNGEHMVAEAMKNAMLDNRISDLHVERKLPICGDVEKELNRAVKRKVTWQDPVALSV