wanglab/gogpt-training-data huggingface dataset:
Protein: Putative lipid phosphate phosphatase 3, chloroplastic (AtLPP3) (EC 3.1.3.-) (Phosphatidate phosphohydrolase 3) (Phosphatidic acid phosphatase 3) (Q8LFD1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Phosphatidate phosphatase PAH2
- Phosphatidate phosphatase PAH1
- Diacylglycerol O-acyltransferase 2
- Diacylglycerol O-acyltransferase 1
- Putative phospholipid:diacylglycerol acyltransferase 2
- Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial
- Phospholipid:diacylglycerol acyltransferase 1
- Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 4
- Sulfoquinovosyl transferase SQD2
- Choline/ethanolaminephosphotransferase 1
Sequence:
MARFSFPCFPNFGGFNQAVTNRGPEISETADNWVSPSDIPLIEPNSKEHRMREAQLGGHTLRSHGMTVARTHMHDWIILVLLVILECVLLIIHPFYRFVGKDMMTDLSYPLKSNTVPIWSVPVYAMLLPLVIFIFIYFRRRDVYDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSLGDVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAFDGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTICYLQFFPPPYHTEGWGPYAYFQVLEAARVQGAANGAVQQPPPQVNNGEEEDGGFMGLHLVDNPTMRREEDVETGRG
Protein: Kinetochore protein SPC25 (P40014)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:11179222}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11179222, ECO:0000269|PubMed:11266451}. Note=Associated with kinetochores. {ECO:0000269|PubMed:11179222}.
Interaction partners:
- Kinetochore protein NUF2
- Kinetochore protein NDC80
- Kinetochore protein SPC24
- Kinetochore-associated protein DSN1
- Inner kinetochore subunit CNN1
- Outer kinetochore KNL1 complex subunit SPC105
- Kinetochore-associated protein MTW1
- Kinetochore-associated protein NNF1
- Kinetochore-associated protein NSL1
- Inner kinetochore subunit AME1
Sequence:
MASIDAFSDLERRMDGFQKDVAQVLARQQNHARQQLQQFQAEMRQLHNQHQHLIDELQRLATQRTALQQQIHAAQQATNTTREQWRSYHERESELSRRQSTLAAQSRELDSLLQQRGKECVQLRARWAAQSGNDAAEVALYERLLQLRVLPGASDVHDVRFVFGDDSRCWIEVAMHGDHVIGNSHPALDPKSRATLEHVLTVQGDLAAFLVVARDMLLASL
Protein: Dahlein-1.2 (P84263)
Organism: Ranoidea dahlii (Dahl's aquatic frog) (Litoria dahlii)
Function: Weak wide spectrum antimicrobial activity against Gram-positive bacteria.
Subcellular location: Secreted {ECO:0000269|PubMed:11555873}.
Interaction partners:
Sequence:
GLFDIIKNIFSGL
Protein: Stage II sporulation protein D (Stage II sporulation protein C) (P07372)
Organism: Bacillus subtilis (strain 168)
Function: May act at the level of sigma-G activity or its stability. SpoIID is probably required for engulfment.
Interaction partners:
- Stage II sporulation protein P
- Stage II sporulation protein M
- Stage II sporulation protein Q
- Stage III sporulation protein AH
- Stage IV sporulation protein A
- Stage II sporulation protein B
- Stage IV sporulation protein FA
- Stage II sporulation protein E
- Stage III sporulation protein AA
- Stage II sporulation protein R
Sequence:
MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVSTKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQALAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDAVASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKATKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNSADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADAFLNKYMAKK
Protein: Homeodomain protein HOX3 (Q66Q67)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MDCGSGGGGLGASGSGGDHDSSDLSRRKKPYHRHTAHQIQRLESMFKECPHPDEKQRLQLSRELGLAPRQIKFWFQNRRTQMKAQHERADNSALRAENDKIRCENIAIREALKNVICPSCGGPPANEDSYFDDQKMRMENAQLKEELDRVSSIAAKYIGRPISQLPPVQPVHISSLDFRMASFDGYGVGAGPSLDLDLLPGSSSSMPNLPFQPVVISDIDKSLMSDIAANAMEELLRLLQTNEPLWIKSTNDGKDALNLESYERIFPKPNNTHFKSPNIRVEASRDSGVVIMNGLALVDMFMDSNKWLELFPTIVSIAKTIEVISPGMLGTHRCSLQLMYEELQVLSPLVPTREFYTLRYCQQIEQGLWAIVNVSYDLPQFASQCRSHRLPSGCLIQDMPNGYSKVTWLERVEIEDKTPIHRLYRDLVHSGSAFGAERWLTTLQRMCEWFACLRVSSTSTRDLGGVIPSPEGRRSMMKLAQRMVNNFCTSVGTSNSHRSTTLSGSNEVGVRVTVHKSSDPGQPNGIVLSAATTFWLPVSPQNVFNFFKDERTRPQWDVLSNGNAVQEVAHIANGSHPGNCISVLRAFNTSHNNMLILQESCIDSSGSLVVYCPVDLPAINVAMSGEDPSYIPLLPSGFTITPDGHLEQGDGASTSSSTGHGRSSGGSLITVAFQILVSSLPSAKLNLDSVTIVNNLIANTVQQIKAALNCPSS
Protein: Chrysophsin-2 (P83546)
Organism: Pagrus major (Red sea bream) (Chrysophrys major)
Function: Has antibacterial activity against Gram-positive bacteria B.subtilis ATCC 6633, L.garvieae ATCC 49156 and S.iniae F-8502, and Gram-negative bacteria E.coli WT-2, V.anguillarum ATCC 19264, V.penaeicida KHA, V.harveyi ATCC 14126, V.vulnificus ATCC 33148 and A.salmonicida NCMB 1102. Has hemolytic activity against human red blood cells. Seems to disrupt the membranes by adopting an alpha helical conformation. May play a significant role in innate host defense.
Subcellular location: Secreted.
Interaction partners:
Sequence:
FFGWLIRGAIHAGKAIHGLIHRRRH
Protein: GEO08327p1 (RH37427p) (TRAPP subunit 33) (Q9VF82)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000256|ARBA:ARBA00004222}.
Interaction partners:
- Trafficking protein particle complex subunit 5
- FI18195p1
- Probable trafficking protein particle complex subunit 2
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 11
- RE19263p
- Trafficking protein particle complex subunit 10
Sequence:
MSEEILFDCLHAEIVNYCLDSNKEHDLATLEYIGFTTGYRLIERLTREVSRFKDELETMKFICTDFWMLIYKKQVDNLRTNNHGMYVVQDKAFRFLTRISPGTKQLEHAPKFVAFTCGLVRGALSNLGINSTVTAEVQSIPACKFHIEVNRN
Protein: ATP-dependent rRNA helicase spb4 (EC 3.6.4.13) (O74764)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P25808}.
Interaction partners:
- AdoMet-dependent rRNA methyltransferase spb1
- 25S rRNA
- Ribosome biogenesis protein ytm1
- Ribosome biogenesis protein erb1
- Probable nucleolar GTP-binding protein 1
- Ribosome biogenesis protein nsa2
- GTPase grn1
- Ribosome biogenesis protein rlp24
- Uncharacterized RNA-binding protein C1827.05c
- Nucleolar complex-associated protein 3
Sequence:
MSFQSINIDKWLKNAVAAQGFKKMTPVQANAIPLFLKNKDLVVEAVTGSGKTLAYLLPCFDKVTRRDTDETGLGALIVAPTRELATQIFNVTKELLAYQPDSLDGGKKLVADMYIGGKGTLTNDLASFREKNPSVVIGTPGRLNEMLSHISSKHLEILILDEADTLIDMGFQRTLQSIISQLPKQRRTGLFSATMNDTVSSFLKIAGLRNSVRVSVTVTSKKIDTRTPSSLAIQSLVIPPIYKVQCMIHLLCTIEYEKAIVFFSSCASVEYFNSLFLTYKLPFEIVALHGQQVQSNRSRNFEKFKKSNKKTVLFTTDIASRGLDIPNVDFVLQLDPPLDPKSFSHRCGRAGRAGRAGVAIVLLNDGREEEYEELLRVRKVPITRIDTPIEALDLSRLKVLTHELRKIVSKDRDLYDKGLRAFVSHVRAYTKHHASFIFRIKDLDLGQLATAYALLHLPKMPELKDTEISENIFKKFDIDYATIPYRDQVREQARRRRLEVEKTEPKKLARPAKIKNEAWSKQKEVKEKRNTRREKRKSKKEFLKAQKNEASNNLKQEIVSKAGAQETENDDLIDEESDALSELEEDYRQLKKSKKRKNQASFGFSM
Protein: Crotonobetaine/carnitine--CoA ligase (EC 6.2.1.48) (Betaine:CoA ligase) (P31552)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.
Interaction partners:
- L-carnitine CoA-transferase
- Carnitinyl-CoA dehydratase
- Crotonobetainyl-CoA reductase
- L-carnitine/gamma-butyrobetaine antiporter
- Carnitine operon protein CaiE
- Protein FixC
- Protein FixA
- Protein FixB
Sequence:
MDIIGGQHLRQMWDDLADVYGHKTALICESSGGVVNRYSYLELNQEINRTANLFYTLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLCEESAWILQNSQACLLVTSAQFYPMYQQIQQEDATQLRHICLTDVALPADDGVSSFTQLKNQQPATLCYAPPLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMPAFHIDCQCTAAMAAFSAGATFVLVEKYSARAFWGQVQKYRATVTECIPMMIRTLMVQPPSANDQQHRLREVMFYLNLSEQEKDAFCERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRVGFCYEAEIRDDHNRPLPAGEIGEICIKGIPGKTIFKEYFLNPQATAKVLEADGWLHTGDTGYRDEEDFFYFVDRRCNMIKRGGENVSCVELENIIAAHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGETLSEEEFFRFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIRKNLK
Protein: Cell division cycle-associated protein 7 (Protein JPO1) (Q9BWT1)
Organism: Homo sapiens (Human)
Function: Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163.
Interaction partners:
- Lymphoid-specific helicase
- Zinc finger and BTB domain-containing protein 24
- 14-3-3 protein zeta/delta
- Cell division cycle-associated protein 2
Sequence:
MDARRVPQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASDNFANTRLQSVREGCRTRSQCRHSGPLRVAMKFPARSTRGATNKKAESRQPSENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFRGRHPLPGSDSQSRRPRRRTFPGVASRRNPERRARPLTRSRSRILGSLDALPMEEEEEEDKYMLVRKRKTVDGYMNEDDLPRSRRSRSSVTLPHIIRPVEEITEEELENVCSNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNRYGEEVRDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQA
Protein: Centrosomal protein 224 (CP224) (Q1ZXQ8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in regulation of microtubule dynamics. Regulates the interaction of microtubules tips with the centrosome and cell cortex.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.
Interaction partners:
- Microtubule-associated protein RP/EB family member 1
- Tubulin alpha chain
- Kinetochore protein Ndc80
- Kinetochore protein Nuf2 N-terminal domain-containing protein
- Uncharacterized protein
- Tubulin beta chain
- Probable serine/threonine-protein kinase ndrC
- Spindle pole body component 98
- Tubulin alpha chain
- Lamin-like protein
Sequence:
MGDEEAPSGSIEDRINHKNWKWRVSGLEELTTKFRNSIEGSGPLFNEWGPQFKKILADINPMSQERALEPLSAFIDRCDCVNKFAASYVGVLVEKLFASTRPRAKEKTIECLLLTIEADSAEPVVEALLKGTSSTSPKILLASLAALTQALKTFGPKQIPVKLILKQFSPWFENRDKGIRDQASELFIEIYRWIGKALIPLISEALTPIQLKALQDQFEKLPTDPAVPLKYTRSEAAKALANASKGIQAKPEVVEEIDPYSLMTAVNILPKLTSEFYEGLQAKKWQERSEQMDKLVTILTNTPKIETADFSELCKALKKILADVNVMIVQKAVVSIGLLADSLRGGFTSYVKPFITPILEKFKEKKTSVLQSVHTTMDSLVGKSISLSDIIDELTATMQSKVPQIKQEVLVFICNSITNTKKPADITKVTKQLTKIFMEALNDTDSNIRDNASKAFAALGGIIGERAMTPYLNQIDPIKAKKIKDNMPAVATPVTITPQPLAPVDLKDIDLPVSSSNKKPAAATGNSKSSSTTTPTGRSSNSSPLPPPPSSSDDIKNKLIGAGIVNNEIIEGLGKTQWKDRLQAVDDILENVKGLTADSINGMSESIIQLLCDKPSLKESNFQVLSSIFSIFIQCCKNDSNFTQQRCANSYLTTCIEKLTDVKLKEISSELLFSTGESITPHAVFTSIYQFTSNHKNPKIIADSLVWIQQAIDEFGIGCCSNGIQQLKPLLDYTKQCLESTNPDVKKSAIKLLCTIKINIGATLTDFLGDVKKPTMEVLDREFQKIRDQKPPVPNRQWKGMPPPGSAPVQIEFPRVDISVKLTPAIITNLSDANWKTRSDALDEIERIIIDANRKIQPKLGGLIPALKNRLTDNNQKCTITTLNIIGMLSQAMGGQSFEKHARLLIPGILLLLGDSKKPVRDAVISCMNVIVQSDLGFDVFIGSLAAPMIQESAFTRKESLAWTIVNVTNMKAAPIPSEINTLAKGIISCLQDKSAEIRSLADNLLSILCTQIPLIEFKKELKHVKPASQPSIQTILDKYYQKTGQPIPPPSKTKQSTSSSSSSSSTTSQQSSTPSSPQPIRQQQQQQQQQPTQPQQQQQQQQRRSILQSNNGASNCEFIIFDINGKMNRQKTNQIPSWHFIEPTEEVVEILQDQVLQCFTEEFANLMFSSLPSNSQHMSDLMIGMIEQNPEAIISVLDILFRWITFKLFDTGLASQKRVLKILEILLNKLIDSEYSIGEYEASCLVPILLEKSGSATNEQIKQIFKQSIQQLEELCLPNVLFRFAIEMVTSQNWRTRVEVLNVMASIIDKNGASVCGNLKVVIPLITQNLNDSQSKQSSLLCLNKLYSHIKDECFKYSNISQQDKILIIGNNNNNNNNNNNNNNNNNNNNVQQQQQQQQQQQQQQPRKSLSTDEMSTQLIGCLELLKNYSITKENIEHTVEALKQFSGLMANGKLDDVFVNFAEEYFLVLTSILADTFPQVSKDATILRLCKYLIHTIISILSNKVVAKQCNVRCLEIVLNETIKLYSLAESNSSKQGTESELSKAFNQILLRILQNCNSTILFSTLLQMMSRTDNDQSIQHPGKYNDLLLRCLLRATKSLTTPSILEELNVETVLSEINSFLKSNPSLDEITRKTTKTLTSELYQNRTNQVVKFTKDIISKGQQQKYQYLLNLLIELVPKQFEDLINGNGNGNRISSGGSNNNNNNGGRVSSGGNNNNNSGRENINNININSSLDSPINDHHNSNNTTTTTTRSRTSTGSSNSQQQQLPTTSANTTTTTTTTTTTGKTQSTLSTLKINKEPRDYSGKTDSQKKELLIEIFKKIGNKDLTLDGIHDLYFFIREYPDYDITPNLNSSSQQFQAYITRNLKKIKDSMDAPKDKDDEVVNYQERLKVIQNTFYNQHNQPSSQVVNNNNNNNNNNNNNNNNNINNNNNNNNNSGGNENIAPQLSNTASMASNTLQRLRTLNPDQNSGSNNNNSHQNSPSTSSSNDLNSTVASLRQRLAQLTSKSNE
Protein: CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7) (LNV) (Q9ESD6)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Spectrin beta chain
- CKLF-like MARVEL transmembrane domain-containing protein 8
- CKLF-like MARVEL transmembrane domain-containing protein 3
- Chemokine-like factor
- CKLF-like MARVEL transmembrane domain-containing protein 6
- CKLF-like MARVEL transmembrane domain containing 1
- CKLF-like MARVEL transmembrane domain-containing protein 5
- Galectin-4
Sequence:
MSHGSGLVRTTCSSGGALGPGQPSEGLLDRVYPLTHGALFKVAQMVTLLIAFICVRSSVPIDYGAHSFFEVVTMCDLIMILIFYLVHLFRFYRVLTCISWPLSELLHYLIGTLLLLIASIVIASKSYNQSGLVAGAIFGFLASFLCLASLWLSYKITCITQSSDASA
Protein: Interleukin cytokine-related protein 17.1 (Interleukin 17 cytokine-related protein 1) (Q22687)
Organism: Caenorhabditis elegans
Function: Ligand for the receptor complex composed of ilcr-1 and ilcr-2. Binding to the ilcr-1/2 receptor complex triggers a signaling cascade, activating the downstream signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. Plays a role in the responsiveness of RMG interneurons to ascaroside pheromones.
Subcellular location: Secreted {ECO:0000269|PubMed:28099418}.
Interaction partners:
- Interleukin cytokine receptor-related protein 2
- ACT1-like protein
- Interleukin cytokine receptor-related protein 1
- ANK repeat-containing protein nipk-1
- Interleukin-17
- Pelle-like serine/threonine-protein kinase pik-1
- G-protein coupled receptors family 1 profile domain-containing protein
Sequence:
MPKSPHRTNLQSFYPIMIILTHLALDSNCWRIRREVDGEEEDIMPSEECYHKYNEENHFKVFSNYLNRKNSSHYSPIAPSYQQALLRLQVKGLKHGEQITKSSGKCNSKKLDTISAETPLRDRALCKFEYVLNYNPKRLPAALTEVKCSCPRPNSKLVGKRIFECEHLRYQVRVLMWDDSCNTFREHVETIALACIPVIQANANADGDDDFIYTIKAEIPI
Protein: Disease resistance protein (TIR-NBS-LRR class) family (F4I901)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Late embryogenesis abundant
- Probable disease resistance protein At5g66900
- Probable disease resistance protein At5g45490
- Probable disease resistance protein At5g04720
- Uncharacterized protein F24D7.14
- Expressed protein
- Protein DA1-related 5
Sequence:
MVSSSAPRVSKYDVFLSFRGEDTRKTIVSHLYAALDSRGIVTFKDDQRLEIGDHISDELHRALGSSSFAVVVLSENYATSRWCLLELQLIMELMKEGRLEVFPIFYGVDPSVVRHQLGSFSLVKYQGLEMVDKVLRWREALNLIANLSGVVSSHCVDEAIMVGEIARDISRRVTLMHKIDSGNIVGMKAHMEGLNHLLDQESNEVLLVGIWGMGGIGKTSIVKCLYDQLSPKFPAHCFIENIKSVSKDNGHDLKHLQKELLSSILCDDIRLWSVEAGCQEIKKRLGNQKVFLVLDGVDKVAQVHALAKEKNWFGPGSRIIITTRDMGLLNTCGVEVVYEVKCLDDKDALQMFKQIAFEGGLPPCEGFDQLSIRASKLAHGLPSAIQAYALFLRGRTASPEEWEEALGALESSLDENIMEILKISYEGLPKPHQNVFLHVVCLFNGDTLQRITSLLHGPIPQSSLWIRVLAEKSLIKISTNGSVIMHKLVEQMGREIIRDDMSLARKFLRDPMEIRVALAFRDGGEQTECMCLHTCDMTCVLSMEASVVGRMHNLKFLKVYKHVDYRESNLQLIPDQPFLPRSLRLFHWDAFPLRALPSGSDPCFLVELNLRHSDLETLWSGTPMLKSLKRLDVTGSKHLKQLPDLSSITSLEELLLEQCTRLEGIPECIGKRSTLKKLKLSYRGGRRSALRFFLRKSTRQQHIGLEFPDAKVKMDALINISIGGDITFEFRSKFRGYAEYVSFNSEQQIPIISAMSLQQAPWVISECNRFNSLRIMRFSHKENGESFSFDVFPDFPDLKELKLVNLNIRKIPSGICHLDLLEKLDLSGNDFENLPEAMSSLSRLKTLWLQNCFKLQELPKLTQVQTLTLTNCRNLRSLAKLSNTSQDEGRYCLLELCLENCKSVESLSDQLSHFTKLTCLDLSNHDFETLPSSIRDLTSLVTLCLNNCKKLKSVEKLPLSLQFLDAHGCDSLEAGSAEHFEDIPNKEAHTRNDYFQETEMSSYVLKTQATRNRQTIRLPKITHAVMYVGIPICITLVAALVILLLRVFK
Protein: SH3 domain-binding protein 1 (3BP-1) (P55194)
Organism: Mus musculus (Mouse)
Function: GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (By similarity).
Subcellular location: Cell projection {ECO:0000250|UniProtKB:Q9Y3L3}. Cell junction, tight junction {ECO:0000269|PubMed:22891260}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Y3L3}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q9Y3L3}. Nucleus {ECO:0000250|UniProtKB:Q9Y3L3}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y3L3}. Note=Localizes at the leading edge of migrating cells. Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content. {ECO:0000250|UniProtKB:Q9Y3L3}.
Interaction partners:
- Exocyst complex component 8
- Exocyst complex component 2
- Exocyst complex component 4
- Rab effector MyRIP
- WASH complex subunit 1
- Exocyst complex component 3-like protein
- Septin-2
Sequence:
MMKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKRAAHNVHKRLQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMTCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQAAKNSGSNQGLGGASGSHTHTTTANKVEMLKEEEEELKKKVEQCKDEYLADLYHFSTKEDSYANYFIHLLEIQADYHRKSLTSLDTALAELRDNHSQADHSPLTTAAPFSRVYGVSLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHDVCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQNADTLFPGDINFNVSGIFPGLAPQEKVSSQQVSEELPPVTVPAPATTPAPTPAPASMAVRERTEADLPKPTSPKVSRNPTETAASAEDMTRKTKRPAPARPTMPPPQPSSTRSSPPAPSLPPGSVSPGTPQALPRRLVGTSLRAPTMPPPLPPVPPQPARRQSRRLPASPVISNMPAQVDQGVATEDRGGPEAVGGHPPPPALPPQPRPRGLISETE
Protein: Dynein axonemal assembly factor 6 (PIH1 domain-containing protein 3) (Sarcoma antigen NY-SAR-97) (Q9NQM4)
Organism: Homo sapiens (Human)
Function: Plays a role in cytoplasmic pre-assembly of axonemal dynein.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28176794}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:28176794}. Note=Localized to the cytoplasm of spermatogenic cells. {ECO:0000250|UniProtKB:Q3KNI6}.
Interaction partners:
- Dynein axonemal assembly factor 4
- Protein kintoun
- Sperm-associated antigen 1
- Dynein axonemal assembly factor 11
- PIH1 domain-containing protein 2
- Dynein axonemal assembly factor 3
- Dynein axonemal assembly factor 1
- A-kinase anchor protein 14
- Dynein axonemal intermediate chain 2
- Dynein axonemal assembly factor 5
Sequence:
MESENMDSENMKTENMESQNVDFESVSSVTALEALSKLLNPEEEDDSDYGQTNGLSTIGAMGPGNIGPPQIEELKVIPETSEENNEDIWNSEEIPEGAEYDDMWDVREIPEYEIIFRQQVGTEDIFLGLSKKDSSTGCCSELVAKIKLPNTNPSDIQIDIQETILDLRTPQKKLLITLPELVECTSAKAFYIPETETLEITMTMKRELDIANFF
Protein: Transcriptional regulator of yeast form adherence 2 (Q59LX5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor required for yeast cell adherence to silicone substrate.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- RRM domain-containing protein
- C3H1-type domain-containing protein
- mRNA-binding protein
Sequence:
MNRSSYSSQSDNRYSRNPAVLCSFYSKIGACRHGEKCSKKHLKPISSRTILLANLYQNPTLNDDDYGHANGIGSETSQIIDNESVIKNSDTVGTVSQIDDSPHSNSGEVTKDETVETQEVETENSENIAETGDVKIDHNEDQKQIEDVKESDKVESSEEVQQDDKLHKEDTLEKESEDNIKQDENIEDAKLEDTEKDKLPEFTISQSQKDFDQFFQDIFVHISKLGQIRDIAVCENENNHLAGNVYVMFESAEDAYNANLQLNQEWYNGKPVYSDLSPVNDFNDACCEEYRDYHDCQRGAMCNYMHVRLPSSDIEESLYESQAKSYMLKQLEELKKELPGDIRSSSSTNDDETNGNENGISSTMAVLEQLS
Protein: Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3) (P16233)
Organism: Homo sapiens (Human)
Function: Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
Subcellular location: Secreted {ECO:0000269|PubMed:25862608}.
Interaction partners:
- Colipase
- Gastric triacylglycerol lipase
- Inactive pancreatic lipase-related protein 1
- Bile salt-activated lipase
- Patatin-like phospholipase domain-containing protein 2
- 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
- Monoglyceride lipase
- Hepatic triacylglycerol lipase
- Chymotrypsinogen B
- Lipoprotein lipase
Sequence:
MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC
Protein: Diuretic hormone 31 receptor, isoform A (A1Z9B7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MSDQIGNPNATFSGSGSGSGTNVASIAESVAESGPDFDALRAACETRLNASGQLAGSGGPGAEAGTHCAGTFDGWLCWPDTAVGTSAYELCPDFITGFDPARYAHKECGLDGEWFKHPLTNKTWSNYTTCVNLEDLNWRHTVNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANNSLWLVWYLLVMPNSELLHQSPMRCVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMNQTNYQNILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYEIISAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCFSNRPRTNSYTATQVSFVRCGPPLPGEEKV
Protein: Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) (OF45) (Osteoregulin) (Q9ES02)
Organism: Rattus norvegicus (Rat)
Function: Regulates renal phosphate excretion (By similarity). Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (By similarity). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Increases dental pulp stem cell proliferation.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q8K4L6}. Secreted {ECO:0000250|UniProtKB:Q9NQ76}.
Interaction partners:
- Dentin matrix acidic phosphoprotein 1
- Phosphate regulating endopeptidase X-linked
- Osteopontin
- Fibroblast growth factor 23
- Sclerostin
- Integrin-binding sialoprotein
- Parathyroid hormone
- Secreted frizzled-related protein 4
- Enamelin
Sequence:
MQAVSVGLFLFSMTWAAPKLNEDGSSGGNQGNIHLASVKPEPMVGKGTEGGRDAPLHLLDQNRQGATLLRNITQPVKSLVTGTEVQSDRNKEKKPQSVLSVIPTDVHNTNDYSEDTENQQRDLLLQNSPGQSKHTPRARRSTHYLTHLPQIRKILSDFEDSASPDLLVRGDNDVPPFSGDGQHFMHTPDRGGAVGSDPESSAGHPVSGSSNVEIVDPHTNGLGSNEIPGREGHIGGAYATRGKTAQGAGSADVSLVEGSNEITGSTKFRELPGKEGNRVDASSQNAHQGKVEFHYPQAPSKEKVKGGSREHTGKAGYNEIPKSSKGGASKDAEESKGNQVTLTESQRFPGKGKGQSSHSLGNEVKSEEDSSNSLSREGIAIAHRRTSHPTRNRGMSQRRGSWASRRPHPHRRVSTRQRDSSESSSSGSSSESSGD