wanglab/gogpt-training-data huggingface dataset:
Protein: DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) (P33991)
Organism: Homo sapiens (Human)
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular location: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}.
Interaction partners:
- DNA replication licensing factor MCM5
- DNA replication complex GINS protein SLD5
- Protein MCM10 homolog
- Protein DBF4 homolog A
- DNA replication licensing factor MCM2
- DNA replication licensing factor MCM6
- DNA replication factor Cdt1
- Cell division control protein 45 homolog
- DNA replication complex GINS protein PSF3
- WD repeat and HMG-box DNA-binding protein 1
Sequence:
MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL
Protein: GNB5 protein (A5PJS1)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
MAADGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRLVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
Protein: General vesicular transport factor p115 (Q9W3N6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for maintaining the architecture of the Golgi stacks and for normal organization of the transitional endoplasmic reticulum (tER). Required for both the formation of the Golgi stacks and the maintenance of the individual cisternae.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12876273}. Golgi apparatus, Golgi stack {ECO:0000269|PubMed:11514618, ECO:0000269|PubMed:12876273}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:11514618, ECO:0000269|PubMed:12876273}; Peripheral membrane protein {ECO:0000269|PubMed:11514618, ECO:0000269|PubMed:12876273}. Endoplasmic reticulum {ECO:0000269|PubMed:11514618, ECO:0000269|PubMed:12876273}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12876273}; Peripheral membrane protein {ECO:0000269|PubMed:12876273}. Note=Associates with the tER membrane (PubMed:12876273). Localizes in developing Golgi stacks (PubMed:11514618). {ECO:0000269|PubMed:11514618, ECO:0000269|PubMed:12876273}.
Interaction partners:
- Syntaxin-5
- Probable Golgi SNAP receptor complex member 2
- BET1 homolog
- Golgi SNAP receptor complex member 1
- Grasp65
- FI01544p
- Golgi matrix protein 130 kD
- Protein sly1 homolog
- Coatomer subunit beta
- LD39211p
Sequence:
MEFLKSGIKTVLGSTEPGQQPSAAETVEKLVDRVYSSTLLEDRRDACRALKALSRKYRIEVGAQGMPPLVQVLQNDGQDAEIISYALDTLCNVVTSEEFDEEADNPTVSVNVGEQFTEMFIKTPEHVTLVMGYLDEYDFRVRRAAIQLITSLISNKTRELQDLILVSPMGVSKLMDLLTDSREVIRNDVLLLLIELTKGNSNIQKIVAFENAFDRLFEIVREEGCSDGGIVVEDCLILLLNLLKNNSSNQQFFKEGSYIQRLSPMFELSQDAEEVGWSPQKVSNFHCLLQVVRALVTPSNQQQVVAACQRVMQKSRLLHALCEILMSSGVPADILTETINAVAEVVRGDRDNQDELGRVMAPSSPPRPAIVVLLMSMINEKQLLALRCAVLYCFECFLYRNADGQRAVVQTLLPSSASDVSALSTGQLLCTGLFSTDALANWFSAVALMHSLVENVALKEELLRVLLATPGGQKPITLLEQCTNLMQQERYRLQSKVGLLMLLSLWLAHCPGAVKALLETQGTMAYLTAQLCSNEHDEREFLVQGMCAFLMGLCIQFNDNSLPGQKREDISQLIIKRIGQESFCSKLAEVSRHEAYSRACKQAQIRAKSAGELLLDFEYCKLYKGLEALIAKLVSGFDVDGIELTELTLSSEASALVSQYKGIIRGMDAQIQALQQSSKELEQENAELKEKLGEEQSLKAQLLDQNTLLKAQLGASTGQVQSAQGAEATPPNEEELNAARYQANMYFAENIRLTKELETLRQQLSAEKQSADAAQDSLAAMQKDQEDLLELLADQEAKLTRYEEAGSTNTLPTSNVAPSVPAAGGGSPIPSGTASR
Protein: At3g63390 (Q1H5D6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMEDDDDFSAAATTVVFDRPIPLLRGPVPSGGSYVLAFRSLDSWSAAFKRCETLIKDQCEEGAKIGCAVSASNNCKPPWWRGSGGDMREREKCEEREFEGCVAAAKGKCAAFAKDKCSGAFLDARIAKDKEVEGLVWLASMPEESRWRDLMGLGGSLRLHTNNCCCTARDLLLKP
Protein: Fructose-1,6-bisphosphatase 1 (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) (A0A060Y8H0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Transketolase
- transketolase
- Transketolase N-terminal domain-containing protein
- transketolase
- malate synthase
- Transketolase N-terminal domain-containing protein
- transketolase
- Transketolase-like pyrimidine-binding domain-containing protein
- Ribulose-phosphate 3-epimerase
- Transaldolase
Sequence:
MSDRGSFDTNVVTLTRFVLEEGRKAKGTGELTTLLNSICTAVKAISTAVRKAGIANLYGIAGSTNVTGDQVKKLDVLSNDLVINMIKSSFTSCVLVSEEDERALIVEPEKQGKYIVCFDPLDGSSNIDCLVSIGTIFAIYRKTTDDEPNEKDALQSGRHIVAAGYALYGSATMMVLSTGQGVNCFMLDPSIGEFILTDKDVKIKKRGKIYSLNEGYAQHFYPDVTEYLKKKKYPEDGSAPYGGRYVGSMVADVHRTLVYGGIFLYPANVKSPKGKLRLLYECNPMSFIIEQAGGMATTGEMNVLDIQPENIHQRVPVVLGSPEDVQEYIAIYKKTRM
Protein: Kelch domain containing 2 (G3V3U8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAKLRSSHLL
Protein: Vasohibin (Q387E4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYSSDRVRTVMEQLASMNPYTNAKSLPEVPRPDELSIPRKLSSRLQIPYVQNILNSLSYNFLPNTFFCLEKHRSLQSILFTSKEILAEALPIRCLEATFVGLYLTQDLKDVDRIPLSFKSRAKGRAYHHIVLVIRCNSMYGAVGLSRKSTLMDKPLIYNGLYQLIMEYKKQYEAIGHELVDFKLGLCVNHKRDSRKAPCWRYIAVKLGRSTAPSTSTSPRPQEQQEEVSTNEVDVSLISNSGGCSCGDGIEKMLKCYSDLLCRLSEEYDNLLTSYSRGASNNNQQVCLKDLHDMDNSSAKVENRRRLEELRQGRSPCGSVGTRCKKRSASRSVSKKRAVSQNDVPSTDRSRVVRLSSAVATKKTARREKAAAANYRQPAASDLKQPREFSSASGEKGDGQLPHVSRGTNGNISPERACRAAEEGCAANPGEEVTGERQSVRNPLLSLALPLLDSKGGELGLTTCQATDRWMLPNSAKGANINDVGRS
Protein: Component of DNA helicase/primase complex (O39494)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Interaction partners:
Sequence:
MPVSHSNGCVCGVSLYSAWAAGPDRARVLLALLCRMDDGGCDAKFALVNVCARGVTALARGARDVTAARLEDLARAAAAPRALPLATLGHAATWKALYVSALAALRAQIGPFRFYRETRFGVDNDTGLLVSAEEPPDAADAAPRAAVLRSALRLAVEEDAVRAAAAAAPAGGGSLARARLCAMRDGHADLSAPGNVVEFELTTKTARFYRIFADIAQPPRKRAGRLADVFAHREYRVRTEGSAAPVVVRALVPVNFDCVVADARAFSPMAAMLVFAQWHAALFTDGPAQVLGFLGPQLNPGGEERDYCFLLGFPGVPLVVSAADAGAVRDDLDAHVLTDGLWPAFGVHVYHALGPWNFLDGAAVASLNRRIAAARAALPPGGSDGSDWPAGRVSTILNSPACVRGLWLAKFDFSAFFPTLYAHLVPEHARLARAICARRDGRPGLKPSLLTFFGGLRHVHAPAYEAVIALANAVAAAVERAANARNFAVCTYVKDGFWGAFGDAAPEVVPREAALAAALALRDDCQRAAEAVLRAAGLHPAEGAELHLRFEGLFTHAVSWSANKYWLWDATAGGAEGELFVGFPCRTEFGRMAKRSLAGLLRRAVAQPERPSDTVAAAAAACDALVHAAFERRGDVRFWSATAPIADWGAVPRSALSGGDLLDADHGPRPYVLVAGHEAAPFPLPWALYRSPVLLPDIACRAHMAPVLQELARMLNGALAALAAREGDDEPPIEEFEYNLADFDFLFA
Protein: Troponin T2d, cardiac (Zgc:114184) (Q4QRC7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSDTEDVMDEAVQEEVDESKSKPKYLSNIQAPKIPEGDKVDFDDIQKKRQEKDLTELQSLIEAHFLQRQKDEEELIALVNRIEKRRAERAEQQRVRAERGKERQARLAEERERKEQEEQRKKHDEDAKKKKALTNMTHQYGGIQQKGEGRKGAKKQTEREKKKKILADRRKPLNIDHLSDDKLKDKATELWQWLMTLEAEKYDLNDKLKRQKYDINQLLCRVKDHQSAKGRGKGKMGGRLR
Protein: Minor capsid protein L2 (P03107)
Organism: Human papillomavirus type 16
Function: Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04003, ECO:0000269|PubMed:19095951}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04003, ECO:0000269|PubMed:19095951}. Host early endosome {ECO:0000269|PubMed:25693203, ECO:0000269|PubMed:30122350}. Host Golgi apparatus {ECO:0000269|PubMed:25693203, ECO:0000269|PubMed:30122350}.
Interaction partners:
Sequence:
MRHKRSAKRTKRASATQLYKTCKQAGTCPPDIIPKVEGKTIAEQILQYGSMGVFFGGLGIGTGSGTGGRTGYIPLGTRPPTATDTLAPVRPPLTVDPVGPSDPSIVSLVEETSFIDAGAPTSVPSIPPDVSGFSITTSTDTTPAILDINNTVTTVTTHNNPTFTDPSVLQPPTPAETGGHFTLSSSTISTHNYEEIPMDTFIVSTNPNTVTSSTPIPGSRPVARLGLYSRTTQQVKVVDPAFVTTPTKLITYDNPAYEGIDVDNTLYFSSNDNSINIAPDPDFLDIVALHRPALTSRRTGIRYSRIGNKQTLRTRSGKSIGAKVHYYYDLSTIDPAEEIELQTITPSTYTTTSHAASPTSINNGLYDIYADDFITDTSTTPVPSVPSTSLSGYIPANTTIPFGGAYNIPLVSGPDIPINITDQAPSLIPIVPGSPQYTIIADAGDFYLHPSYYMLRKRRKRLPYFFSDVSLAA
Protein: Aryl hydrocarbon receptor 2 (E1C4K6)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- AH receptor-interacting protein
- Aryl hydrocarbon receptor nuclear translocator 2.
- Uncharacterized protein.
- Heat shock cognate protein HSP 90-beta
- Uncharacterized protein
- Cytochrome P450 1A5
- Uncharacterized protein.
- Negative regulator of reactive oxygen species.
- Family with sequence similarity 81 member A.
- WD_REPEATS_REGION domain-containing protein.
Sequence:
MYAGRKRKKPVPRSPKPSPPEGVKSNPSKRHRDRLNEELNKLTGLLPFPEDACTRFDKLSTLRLAVGYLKVKNYLMAAGTDVGMLDQPRAPGGNGQTHLQVNRDPFPEGDLLLQALNGFVITVTADGYIFYISPTVQNYLGFHQSDLIYQSIYELIHKDDRAAFHCQLHDAVPDGCSAVGSPNHRCPERFGCMERNFTCRLRCLLDNSSGFLALNFQGRLKQLLGQQKRASDMSLEPLPLALFAIVTPFQPFSILKLQTKMLFFQSKHKLDFTPIACDSWGRVVLGYTEAELCSRGSGYQFVHTADIICCAESHVRVIKTGQTGTTVFRLLTKNGSWVWLQATAWLVYKGDEPDCIISRQRVLSNEEGEEHLRKRNLQLPFSFATGEAILYGNNFPDFLGSFQAKEEFQTKTDSHTVQHAIYPNSITGAMMEQDTSIHLSHTDVPQFTLPDLDAEPDGPSQDGKVGHDKDSSSLLVAIETLFEKSEVDGNISQSLTVGSTELQKWEDTLLSLDMEELPSEDFGERLSSELPSYTEQMLFREGDGKSMEFLHCSEEDCSVAQFQHWGFNPEVPQAFQAPWQPQAAGAQGQDAVLSLGSVMPEGSSAPVEQQILINPASLKEGMLLDALGFSSKPCAVDQLVNSGLEFQAGLPTSIPIDTIIPDCQSQSECTLTGVSCLPPLDSSTLVSQWHDVPVWAKLGSTLGQSTSPGGCPLDAWMTAPEQLEATGASLESQIALNSSSQSWGSFPRQPHCNGEQVLLSKDAWPQPQGLVLGINVCPGTHQTDNIMLHHYEYRTSQGVFRHGNSFLGDAIKTPTSALPCTNHPGTSTGLSSSCSASPSAEVGARASPCELDSVFPLSSLAGRQPLCACHVQLKVWGGDCRT
Protein: Kallikrein-4 (EC 3.4.21.-) (Enamel matrix serine proteinase 1) (Kallikrein-like protein 1) (Serine protease 17) (Q9Z0M1)
Organism: Mus musculus (Mouse)
Function: Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Amelogenin, X isoform
- Matrix metalloproteinase-20
- Enamelin
- Ameloblastin
- Amelotin
- Odontogenic ameloblast-associated protein
- WD repeat-containing protein 72
- Protein FAM83H
- Tuftelin
Sequence:
MMVTARTPWGWFLGCLILEVTGASASSVSSRIIQGQDCSPHSQPWQAALFSEDGFFCSGVLVHPQWVLSAAHCLQESYIVGLGLHNLKGSQEPGSRMLEAHLSIQHPNFNDPSFANDLMLIKLNESVIESNTIRSIPVATQCPTPGDTCLVSGWGQLKNGKLPSLLQCVNLSVASEETCRLLYDPVYHLSMFCAGGGQDQKDSCNGDSGGPIVCNRSLQGLVSMGQGKCGQPGIPSVYTNLCKFTNWIQTIIQTN
Protein: 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) (Q6PAM0)
Organism: Mus musculus (Mouse)
Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity).
Interaction partners:
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- 5'-AMP-activated protein kinase subunit gamma-1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- 5'-AMP-activated protein kinase subunit gamma-2
- 5'-AMP-activated protein kinase subunit gamma-3
- Histone-lysine N-methyltransferase 2D
- 5'-AMP-activated protein kinase subunit beta-1
- Serine/threonine-protein kinase STK11
- Calcium/calmodulin-dependent protein kinase kinase 2
- Glycogen [starch] synthase, muscle
Sequence:
MGNTTSERVSGERHGAKAARAEGGGHGPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVPWQQDLDDSVKPAQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDLSSSPPGPYGQEMYVFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSIKDSVMVLSATHRYKKKYVTTLLYKPI
Protein: Cutinase 2 (EC 3.1.1.74) (Ancut2) (Cutin hydrolase 2) (Q5AVY9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle. Also degrades suberin, a specialized macromolecule found in the cell wall of various plant tissues (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P11373}.
Interaction partners:
Sequence:
MHFKLLSLAALAGLSVASPLNLDERQLGSSSGNDLRDGDCKPVTFIFARASTEPGLLGMSTGPAVCNDLKADASLGGVACQGVGPKYTAGLAENALPQGTSSAAINEAKELFELAASKCPDTRIVAGGYSQGTAVMHGAIPDLSDEIKDKIAGVVLFGDTRNKQDGGQIKNFPKDKIKIYCATGDLVCDGTLVVTAAHFTYVANTGEASKWLEQQLASMPASTSTSSSSSSSSSAPASQTSQSSGLSSWFSGLGN
Protein: Neurexin like receptor 1 (Q19617)
Organism: Caenorhabditis elegans
Function: Required for gap junction formation, playing a role in anchoring the cytoskeletal component F-actin to the membrane of adjacent cells and thus facilitating the formation of gap junction channels in embryonic cells, muscle cells and neuronal cells. Plays a role in maintaining gap junction activity to promote pharyngeal muscle contraction.
Subcellular location: Cell membrane {ECO:0000305|PubMed:33238150}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, gap junction {ECO:0000269|PubMed:33238150}. Note=Partially co-localizes with F-actin at gap junctions between EA and EP endodermal precursor cells in embryos. {ECO:0000269|PubMed:33238150}.
Interaction partners:
- Clc-like protein 2
Sequence:
MSGLCLVLLLSIFAVSQSSGECSDVSFSSVASKLDGLKRVTRLSVSGHISAYHVKVSISDDDFQLVRLSNGNPLVLYSTLSNTPSWTHVDFLATEVRIFPAFEQATEDVRGPLLILTICDYDTPITAFDDSSYTVEAHHAGLVSMYENDLCVVFRTYRSGVFFFSMADQGDVLIAQIIHGTVHVIFDFGSLTPSRISAGKALDDGRWHEMRWLHQFDSVQLSIDGVLLNQTAPTGLYRKLDLHSVVHIGGRPNDDFSQGIETTFTGCIARLQLNNADLLQLSPNEVHNQCQMPKPPSFTLHNSSRAVLPFTFLPFSFEFRIVPINGPLVTLFDAENGTLVDVVIDEESKLHLVSNITKFKQAANPAIDVADGAWHSFSLRIRGVRMEIDIDGYTVLWLEGHEVRRVSQRLSNFILSASGCYRSVTIDLTSVRVDGNVTRGECTFQEKCLPNPCENGGGCVQSALDDYVCNCKEGYKGKNCHTTDLPHSCEEWVFTKGNKQKAVQGRKVLIDIDGGGEMQPINVTCKTERDEIGIDGVSTILEHDLLRPMIVTGDNKPGAVRYSLTYGISTEQMDRLVEGFEACSQFMRYTCRGGARLMTQGDERSPSSWYSTRSDKHGLQWGEAPPYSRMCSCAINGSCLHNRMCNCDSGEDSTDEGVNPYSQLLPVTGLFLGGTTKSSSIEVEIGPLKCRNRATFDPVTFSNRNAKLSGAQTFNQRTFDVSLHVKFSHSQMSILSWHSTDDLHWFHLYVNDGKIVGEVVNGGESQQIVSEHRYDDGKFHAIYWEADSTGMFLKVDGQRKSVKTSFILPTVYMWIVGSRTEKGSTGFAGVIRNVHLCGVELALGQYARKETERGVAIGDDGYCRPDLCQNGGQCVDKYDGYVCDCSMTPFGGSDCTKEYGMMVPAGSSIQIPWQNPAHQAMCHRIAIQTTSRNTTILRSKALFADSTFNMTVDDNGNLQMMAYDGFFFHFKRQSKRHNLSDDIMHDISFCASKHHFNVSVDGMQVITIEGNWTFFESFNVWHFLDENFEGCVSRIQTGSAFPLKNPKTARLNYSGKIRFGTCPIEAVSRQQMYDFNPQPDLISSTIKTSTEDIKIFSVSQNKQDLVSKAIIGGGILALSLFILCMSSLICYMRSRPEGVYKTNETGENCSPSRSEEPLVHNTTSNNNNNPTYASNKEYFC
Protein: WD repeat-containing protein 26 homolog (AtWDR26) (Q9FNN2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a component involved in the crosstalk regulation between light, hormone and abiotic stress response.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22676313}. Note=Associates predominantly in the form of large cytoplasmic complexes. {ECO:0000269|PubMed:22676313}.
Interaction partners:
- Ran-binding protein M homolog
- Protein RMD5 homolog
- At4g09200
- Protein MAEA homolog
- SPla/RYanodine receptor
- Protein GID8 homolog
- ARM repeat superfamily protein
- E3 ubiquitin-protein ligase UPL3
- E3 ubiquitin-protein ligase UPL4
- Protein yippee-like
Sequence:
MGVVEDTEPPLKRAKRLADEPNGFSANSSVRGSSVNSNSLGDLMARPLPSQGDDETIGSKGVIRKSEFVRIITRALYSLGYDKTGAMLEEESGISLHNSTIKLFLQQVKDGKWDQSVKTLHRIGFPDEKAVKAASFLLLEQKFLEFLKVEKIADALRTLRNEMAPLRINTKRVHELASSLISPSSFISHTTSTPGKESVNSRSKVLEELQTLLPASVIIPEKRLECLVENSLHIQRDSCVFHNTLDSDLSLYSDHQCGKHQIPSQTAQILESHTDEVWFLQFSHNGKYLASSSKDQTAIIWEISADGHISLKHTLVGHHKPVIAILWSPDDRQVLTCGAEEVIRRWDVDSGDCVHMYEKGGISPISCGWYPDGQGIIAGMTDRSICMWDLDGREKECWKGQRTQKVSDIAMTDDGKWLVSVCKDSVISLFDREATVERLIEEEDMITSFSLSNDNKYILVNLLNQEIRLWNIEGDPKIVSRYKGHKRSRFIIRSCFGGYKQAFIASGSEDSQVYIWHRSTGKLIVELPGHAGAVNCVSWSPTNLHMLASASDDGTIRIWGLDRINQQNQKKKLVQGSSSNGVIHRCNGN
Protein: Uncharacterized protein (Q581Q4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFRVSRRMLTGGFEGHKPGMENKSLKDKAKGELIKMLKIQLVLVPLVVGWVMIMYPQPSPEEEKRLRAEYEKNAGWKT
Protein: Forkhead box protein N4 (Q96NZ1)
Organism: Homo sapiens (Human)
Function: Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Interaction partners:
- Neurogenic differentiation factor 4
- Neurogenic differentiation factor 1
- Prospero homeobox protein 1
- Pancreas transcription factor 1 subunit alpha
Sequence:
MIESDTSSIMSGIIRNSGQNHHPSPQEYRLLATTSDDDLPGDLQSLSWLTAVDVPRLQQMASGRVDLGGPCVPHPHPGALAGVADLHVGATPSPLLHGPAGMAPRGMPGLGPITGHRDSMSQFPVGGQPSSGLQDPPHLYSPATQPQFPLPPGAQQCPPVGLYGPPFGVRPPYPQPHVAVHSSQELHPKHYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKMSGSSRKGCLWALNLARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKPGEPEAPVLTHATTVAVAHGCLAVSQLPPQPLMTLSLQSVPLHHQVQPQAHLAPDSPAPAQTPPLHALPDLSPSPLPHPAMGRAPVDFINISTDMNTEVDALDPSIMDFALQGNLWEEMKDEGFSLDTLGAFADSPLGCDLGASGLTPASGGSDQSFPDLQVTGLYTAYSTPDSVAASGTSSSSQYLGAQGNKPIALL
Protein: Protein CbrA (CreB-regulated gene A protein) (P31456)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Inner membrane protein CbrB
- Uncharacterized protein YjbG
- ATP-dependent DNA helicase Rep
- Inner membrane protein CreD
- Inner membrane protein YcfT
Sequence:
MEHFDVAIIGLGPAGSALARKLAGKMQVIALDKKHQCGTEGFSKPCGGLLAPDAQRSFIRDGLTLPVDVIANPQIFSVKTVDVAASLTRNYQRSYININRHAFDLWMKSLIPASVEVYHDSLCRKIWREDDKWHVIFRADGWEQHITARYLVGADGANSMVRRHLYPDHQIRKYVAIQQWFAEKHPVPFYSCIFDNSITNCYSWSISKDGYFIFGGAYPMKDGQTRFTTLKEKMSAFQFQFGKTVKSEKCTVLFPSRWQDFVCGKDNAFLIGEAAGFISASSLEGISYALDSTDILRSVLLKQPEKLNTAYWRATRKLRLKLFGKIVKSRCLTAPALRKWIMRSGVAHIPQLKD
Protein: E3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27) (RLIM-like protein) (Q9DBU5)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Subcellular location: Nucleus {ECO:0000269|PubMed:11971979}. Cytoplasm {ECO:0000269|PubMed:16204183}. Cell projection, axon {ECO:0000269|PubMed:16204183}. Nucleus, PML body {ECO:0000269|PubMed:11971979}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000269|PubMed:11971979}.
Interaction partners:
Sequence:
MDPSRSRSGGSGEESSFQENERRWQQERLHREEAYYQFINELSDEDYRLMRDHNLLGTPGEITSEELQQRLERAKEQLASQPGSDSAASDGDSESLRAHSDEDSLLRWLNTFRRTGNVTRSGQNGNQSWRAVSRTNPNSGEFGFSLEIHINPDNRGSEMHGEDSTDIPLSGVNREHRQQRPSSPVARRTRSQTSMSSSGPRGRRGARRQGSVQGSFATLGRLRNGIGVALGVPRVSAPRTNVINSHTNQSDGSTLRQGGRQRFGAAHIWENGARSNVTVRNTNQRLEPIRLRPAFSSRSRSPIQRQNGTVHHNSQRQGRPVQQTGRNRSVRHRGVTRVFLEQGREHRGTDYTPLSNSRLVSRITVEEGESSRSSAATQRHPAITLDLQVRRIRPGETRDRDSIANRTRSRAGLAESTVESTSGGFHRTISHLERSGVRTYVSTITVPLRRISENDVVEPSSVALRSILRQIMTGFGELSSLMEVEPASENQSNGQRLPEVYLELSNGDAADDSGQHGRASSQASQAQDGAEMLAVREPAPPQARPSGSRSRRQLGRADSVVEAGTLPILRLAHFFLLNEGDDDPIRGLTKEQIDNLSTRSYEQDGVDSELGKVCSVCISDYVAGNKLRQLPCLHEFHIHCIDRWLSENCTCPVCRRPVLEFGATSSG
Protein: Protein virilizer (P53185)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus, nucleolus {ECO:0000305|PubMed:36930734}.
Interaction partners:
- Protein MUM2
- Eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 6
- Protein PSP1
Sequence:
MQKCAGHAPLVTAASRVSQDTVDALLQAILKAYHKLASIDSHINDPVEIAFKLINSFKYLPISGSSVKDFESELRELDVFSPLLQSAVTAANNSNIIWDLIAVLFAYISIHKQLHPLILHNLNIWKDFMADNDEETATTTDGDSMNFGVLSLLSIVQNFEEITPNLFEFLKLGLRSTLLKIWVAQWQRYDPSATNLINGDEKISSWITKDYQVDFFIITSLASTSSLEVLPSHYFVYKISKRISHFPNLIDPKLYRSAISTIMENGISDNGGGENSSDKIDPTDLSFHLQVLMEVIDHPELNYLQENRLILLLDIALNYLILVPTHCLHSNFGELGSTQSLASTLNIIQFLLSKFLINMGSISQLINQYNRKCITTNNINNNNINNNGVINGSTNTTSTTTTTITNNNNNSNNSSISNNNRKIDWTQSYQTRYQIPYWFEDSILPPIPPISKSLFTFDKNLDHESDSIMIVNDVLRCLNLTILLISKLLRDYDDLKINPLIQSSDDHSNEDNHVIIEQYMQLYLVPLFTSLLLAQQLKDRGQERDEGHKEKEENINLIGSSSVKKLFSQLIFFSSLKLCENLVIKEKNLALYHLIKFATKVSLDDLILQKISINLLNHLFFHQIRDGSDDDNLIKKLCLKNQLSFQALKDYITLWNDGSEVYNAFYKELFYEEQPKIKPIKLTTSDLLKLFPEDVQFVISTPPNTITSASTSDNCTSSQSAAQKNIENFTTLSKYDVYSSTSFIPSTSKNTNTNVSKQQQQPQNSTPCSSNRFLFNKSSLISQESNGSNNNSGTQGPGSMNESYSLDNSFNTTNTNMTRQPTTLTRATDAMTTAPTTPIPYKNTSGSSNNNLWIESPMTNFKGSTISKSTNKSKMVNTGKNYILGGHNKVKNNSRAQSIHIDDFENENN