wanglab/gogpt-training-data huggingface dataset:
Protein: Homeobox protein Mohawk (Q8BIA3)
Organism: Mus musculus (Mouse)
Function: May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Tenomodulin
- Basic helix-loop-helix transcription factor scleraxis
Sequence:
MNTIVFNKLGGAVLFEDRGTPDRERGSRTFSGFLDNPHTGPEVGIPDGPPLKDNLSLRHRRTGARQNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSDGDSCSEDGENPPRNHMNEEGYSTPAHHTVIKGESSAIKAGGRPESRAAEDYVSPPKYKSSLLNRYLNDSLRHVMATSTAMMGKTRRRNHSGSFSSNEFEEELVSPSSSETEGTFVYRTDTPDIGSTKGDSAANRRGPSKDDTYWKEINAAMALTNLAQGKDEVQGTTSCIIQKSSHIAEVKTVKLPLVQRF
Protein: Alpha-1,4 glucan phosphorylase (EC 2.4.1.1) (A0A1D8PQQ3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- 1,4-alpha-glucan-branching enzyme
- phosphoglucomutase
- Glycogen debranching enzyme
- glucan 1,4-alpha-glucosidase
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogen [starch] synthase
- ornithine carbamoyltransferase
- Phosphoribomutase
- Glucose-6-phosphate isomerase
- glycogenin glucosyltransferase
Sequence:
MPMDYLTPSTLPHPKLKRTNTGFTPNQIIALDAAIPESAKHIWYKYSQLKILDSHKRNGPEDEDNVKSVVDDPDRFEEEFVKHVETSLGRSMYNCDNLAAYQAASNTIRDALVIDWANTQQRQTIQDGKRVYYLSLEFLMGRAMDNALINLNSEQNTQKSLSDLGFNLEDVLDQEPDAALGNGGLGRLAACFVDSLSSKNYSGWGYGLNYQYGIFKQKIIDGYQIETPDYWLNYSNPWVIDRNEIQIPVDFYGYVYEEHDPNTGKVKKNWNGGERVLAVAADFPIPGFNTTNTNNLRLWNAKPTTEFDFSKFNAGDYQQSVAAQQRAESITSVLYPNDNFEKGKELRLKQQYFWVAASLHDIVRRFKKNHKSNWQKFPDQVAIQLNDTHPTLAVVELQRILVDLEGLDWDEAWSIVTKVFAYTNHTVMAEALEKWPVDLVGRLLPRHLEIIYDINYFFLKNVEHRYPNDRDLLRRVSIIEESPKSVRMAYLAIVGSHKVNGVAELHSELIKTTIFKDFVKVFGPDKFTNVTNGITPRRWLRQANPKLAALIAEKLEDPNYDYLTNLGKLKKLEAFVDDYEFLKRWDAIKFDNKRRLATLIKETTDVDVDPTVLFDVQVKRIHEYKRQQLNIFAVIYRYLHIKELLSKGVSIEEIKTKHHIPKASIFGGKAAPGYYMAKTIIHLINKVGDVINNDPEIGNLLKVVFIPDYNVSKAEIICPGSDLSNHISTAGTEASGTSNMKFALNGGLIIGTVDGANVEITREIGEENIFLFGNLAESVEEIRHRHVYEGVKVPESLQKVFHAIESGDFGSPEEFKPLIESIRDHGDYYLVTDDFDLFLEAHKKLEKVYGHHGGDEHDKSHMNEWVKKSVLSVANMGFFSSDRCIDEYAENIWNVEPSNV
Protein: RE31027p (Q8IGU0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNINLPNFNVKNLVKEAGSTISRVVRLTEEKLGTTERTEYDLHFQNLAERADVTKTWTEKIVRDTESVLIPNPQNRVEDFIFEKIEKSKPKRLSNLEHLALDMIEAGGDFGQDLPYGQALIKVGQAEQKLGQCEHDFIATSGICFTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSAERDLRVAQAEFDRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCGDVMEQLQRELANLGGPTPYIPLDVNEASASKSNISSGAAARGPGNNHSANMAATGHKPNQPMHVSTDQMQRARVLCSYDAKDHTELNLSANEVIFVTECSPVNEDYMYGKQGLLKGLVPRAFVEMLDEEHDVTL
Protein: Leucine-rich repeat protein (LRRP), putative (Q57XT8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAKRSRSEGEEQMVTNEDVEKLREEVAELRNHVHMVAAEHEKLREEYDEYRRRPVTWKAVINCDKNAPLECDDPADVIVVDDPGFNLKELSSLKGDVGELRLRRCCGRLDLELLNNQGLYLLEIGPGAVANMSCIGKFPCLQTLILHGTRLDNEWEKGVESLEKLREIVMKNISMLQDAKFLGNALFLDSITIENCPNMNAFTDTLTWPILRRLVITGTSLIVGNGLVEYFHDCVSLKVLRLGDCSAVHSKISLKNCKKLVELCLDNVGVRSTFEWGTELPLLRVLRLTNSGVTDADVKALSAFTTLEEVILSGNKEIVDISPLTNLRSLKVLDLSLCSRARIVGPVDCAPPLEKLLLRATAVTDECVGKLYSTSLSEVDLRFCSTLSKKTSKDIASLRNLRRLFLDDSPEVVFPGRRSPLETLGLCSGSASTTTLETICESATNLTCLRLWYCGGELNVSKLASPKKLRELYICGLRSVSEFAAIASLPELSKLILEGPFVGNKEIEDLSRCEALRSLCVRNAKHLTHVDPVFAIKTLEELSLSDCELLEKISADKSAIRSCVLRLCAIPIAAEGLKKLASQKAIGKLLLERCGSIRLDDIIGVPCTLTDCKEIVCDHMPIPPKIHTVRTPVVVLESAKNRHGW
Protein: Transcription factor CBF/NF-Y/archaeal histone domain-containing protein (Q584G0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Transcription factor CBF/NF-Y/archaeal histone domain-containing protein
- Trypanothione synthetase, putative
- IF rod domain-containing protein
- Uncharacterized protein
- Transcription activator, putative
- Transcription activator, putative
Sequence:
MDEYGDFDNRDTYDTDEAAFLTSRLAMRAEEVEANVSGSQFLNSPRNGSTLDAEEDEEANFTPNVLGGPTNDTPLFYGEELDSLIQSQERNVAGNVTTQNIDASEGDALHIDEHEENDDIDNNDVDDDDEGDDDDDDNNNNNFLIDNYEPPEHTDMASGGSGCEGGGDRTPFALSRVRELLKFHSNSTIVSKDAVTTASEAVVLILQDLTRMAAAQAERNNRKTVRYSDVATVVQHYDRFSFLLDILPPVPEVKKHSSKPVQRQTAIVPTGSKVGQTPRSSQKQQQLQQTGTQRGSHMRQAKLSFGNAADCI
Protein: Serine protease 56 (EC 3.4.21.-) (F2YMG0)
Organism: Mus musculus (Mouse)
Function: Serine protease required during eye development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21532570}; Peripheral membrane protein {ECO:0000269|PubMed:21532570}.
Interaction partners:
- Transmembrane protein 98
- Membrane frizzled-related protein
Sequence:
MPLAMLLLLLLLLSPDSQTAHGHPLYTRLSPGALQVLSAQGTQALQAAQRSAQWAIKRVLMEIQHRLHECQGPGRPRPQAPLLQDPPEPVQCGERHQGVANTTRAHGRIVGGSTAPSGAWPWLVRLQLGGLPLCGGVLVAASWVLTAAHCFAGASNELLWTVMLAEGPQGEQAEEVQVNRILPHPKFDPQTFHNDLALVQLWTPVSPEGPARPICLPQGSREPPAGTPCAIAGWGALFEDGPESEAVREARVPLLSADTCQKVLGPGLRPSTMLCAGYLAGGIDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVTVFKDWLQEQMSAGPSTREPSCRELLNWNAREEEPFTDAPGLCAFYARQCLGSESSCARLALQQCLQRRRRCELRSLAHTLLGLLRGAQELLGPRPGLRRGVSAPARSAPSLQELPGHNPREQRLYSGSRIAGTWLQKPKPERRPETKGCPGLEPLQQKLAAIQRAHAWILQIPAEHLAMNFHEVLADLGSKTLTGLFRAWVRAGLGDQRVVFSGLVGLEPSTLAHSLPRLLVQALKAFRSASLTEGEPQAPWIGADQGQRLGKERQGQLQPPVP
Protein: RAR-related orphan nuclear receptor variant 2 (F1D8P6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
Protein: Traf7 protein (B1WBW7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Ubiquitin-ribosomal protein eL40 fusion protein
- Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
- Anubl1 protein
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Ubiquitin-like protein FUBI
- Ubiquitin-like protein ISG15
- 2'-5'-oligoadenylate synthase-like protein 1
- Ubiquitin-like protein 4A
- Polyubiquitin-C
- Ubiquitin D
Sequence:
MSSAKSARYNRFSGGPANLPASDSSGTRMETTFGPTFSTVTTITKADGTSTYKQHRRTPSSSSTLAYSPRDEEDGMPPINTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNAKLTVVVNNIAVAEQIGELFIHCRHGCRAAGTGKPGVFEVDPRGCPFTIKLSARKDHESSCDYRPVRCPNNPSCPPLLKMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNMLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC
Protein: guanylate cyclase (EC 4.6.1.2) (Q3TNN8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
NEDKVMEIKGQMIHVPESSAILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDGKAIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLELRTDPKPPKPSLSSSRIKKVSYNIGTMFLRETSL
Protein: Large ribosomal RNA subunit accumulation protein YceD (23S rRNA accumulation protein YceD) (G30K) (P0AB28)
Organism: Escherichia coli (strain K12)
Function: Plays a role in synthesis, processing and/or stability of 23S rRNA.
Interaction partners:
- Large ribosomal subunit protein bL32
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein bS16
- Large ribosomal subunit protein bL21
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein bS6
- Small ribosomal subunit protein uS3
Sequence:
MQKVKLPLTLDPVRTAQKRLDYQGIYTPDQVERVAESVVSVDSDVECSMSFAIDNQRLAVLNGDAKVTVTLECQRCGKPFTHQVYTTYCFSPVRSDEQAEALPEAYEPIEVNEFGEIDLLAMVEDEIILALPVVPVHDSEHCEVSEADMVFGELPEEAQKPNPFAVLASLKRK
Protein: TNF receptor-associated factor (F6SA91)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR015614}.
Interaction partners:
Sequence:
MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRGLSPFLGRADMPWCRSHSTRTEVPAQVLCPKSHKGVGIGEGERVVQRVCLEI
Protein: F-box/LRR-repeat protein 17 (F-box-like protein 17) (Q8W104)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein for male fertility. Component of the SCF(ASK-cullin-F-box) E3 ubiquitin ligase complex SCF(FBL17), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Enables the switch in cell cycle control leading to male germ cell lineage formation from microspores after meiosis. Targets CDKA-1 inhibitors the degradation specifically in male germ cells (e.g. KRP6 and KRP7) and thus enables CDKA-1 activation and germ cell S-phase progression. Promotes twin sperm cell production and double fertilization.
Subcellular location: Nucleus {ECO:0000269|PubMed:18948957}. Note=Confined to the male germ cell nucleus of early to mid bicellular pollen.
Interaction partners:
- Cyclin-dependent kinase inhibitor 7
- Cyclin-dependent kinase inhibitor 6
- Cyclin-dependent kinase A-1
- Cyclin-dependent kinase inhibitor 4
- Homeodomain-like superfamily protein
- E3 ubiquitin-protein ligase RHF1A
- Retinoblastoma-related protein 1
- Transcription factor DUO1
- E3 ubiquitin-protein ligase RHF2A
- F-box-like protein
Sequence:
MQPQPHISPNTATAAISAALESQRSRKNRGSYNCGRCGQPKKGHVCLLTAPPDIPTTPIASEPVSCISAAASSSRSTVLSLTAAPSSRQTFTHLRRALSFDDVDARNSLDESDLDAASMDLDLQLDTDIVQPGRFHAVGLWEVLKRLPPSSLLMAARVCKGWRETSRKMWKAAEELRIRVPERAQIGYIGSLLQKCPRLIRLSLKIESDFDATTLACIAFSCPNLEVLEITTSGAAVNRISGDELSRFVANKRGLTSLKMEGCSNLGGFSLSSSSLSTLWLSDLHSLSKMIFNCPNLTEISLEFSRQEDDSTDLVTMVDGLGRTCTRLQNIHIASLKLSHTVVLSLTAVNFRYLRMLSLVLGINITDASVAAISSGYKNLELLDLSGSSITDTGLGMICDVLPDTLSKLLVALCPNITSSGIQFATAQLPLLELMDCGMTVSDPNSDNPTFVENPSPHKTPGYNQKMFIKHKRLKKLSLWGCSSLDALFLNCPELMDLNLNLCSNLHPESLVLQCPKLQLVYASGCQGLLTGAIRKQVSENFSAGENHMPRKRLADASKRIQALPSLYQETREDGIYAGKRRKLEKEMCTIIH
Protein: Integrin alpha-X (CD11 antigen-like family member C) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c) (Q9QXH4)
Organism: Mus musculus (Mouse)
Function: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity).
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Integrin beta-2
- Intercellular adhesion molecule 1
- Integrin beta-2-like protein
- Integrin beta-1
- Complement C3
- Receptor-type tyrosine-protein phosphatase C
- Adhesion G protein-coupled receptor E1
- T-cell surface glycoprotein CD4
- T-lymphocyte activation antigen CD86
- Low affinity immunoglobulin gamma Fc region receptor III
Sequence:
MSCTWIAFLLLLGFVSCLGFNLDAEKLTHFHMDGAEFGHSVLQYDSSWVVVGAPKEIKATNQIGGLYKCGYHTGNCEPISLQVPPEAVNISLGLSLAAATNPSWLLACGPTVHHTCRENIYLTGLCFLLSSSFKQSQNFPTAQQECPKQDQDIVFLIDGSGSISSTDFEKMLDFVKAVMSQLQRPSTRFSLMQFSDYFRVHFTFNNFISTSSPLSLLGSVRQLRGYTYTASAIKHVITELFTTQSGARQDATKVLIVITDGRKQGDNLSYDSVIPMAEAASIIRYAIGVGKAFYNEHSKQELKAIASMPSHEYVFSVENFDALKDIENQLKEKIFAIEGTETPSSSTFELEMSQEGFSAVFTPDGPVLGAVGSFSWSGGAFLYPSNMRPTFINMSQENEDMRDAYLGYSTALAFWKGVHSLILGAPRHQHTGKVVIFTQESRHWRPKSEVRGTQIGSYFGASLCSVDMDRDGSTDLVLIGVPHYYEHTRGGQVSVCPMPGVGSRWHCGTTLHGEQGHPWGRFGAALTVLGDVNGDSLADVAIGAPGEEENRGAVYIFHGASRQDIAPSPSQRISASQIPSRIQYFGQSLSGGQDLTRDGLVDLAVGSKGRVLLLRTRPILRVSPTVHFTPAEISRSVFECQEQVAPEQTLSDATVCLHIHESPKTQLGDLRSTVTFDLALDHGRLSTRAIFKETKTRALTRVKTLGLNKHCESVKLLLPACVEDSVTPITLRLNFSLVGVPISSLQNLQPMLAVDDQTYFTASLPFEKNCGADHICQDDLSVVFGFPDLKTLVVGSDLELNVDVTVSNDGEDSYGTTVTLFYPVGLSFRRVAEGQVFLRKKEDQQWQRRGQHSLHLMCDSTPDRSQGLWSTSCSSRHVIFRGGSQMTFLVTFDVSPKAELGDRLLLRARVGSENNVPGTPKTTFQLELPVKYAVYTMISSHDQFTKYLNFSTSEKEKTSVVEHRFQVNNLGQRDVPVSINFWVPIELKGEAVWTVMVSHPQNPLTQCYRNRLKPTQFDLLTHMQKSPVLDCSIADCLHLRCDIPSLGILDELYFILKGNLSFGWISQTLQKKVLLLSEAEITFNTSVYSQLPGQEAFLRAQTKTVLEMYKVHNPVPLIVGSSVGGLLLLAIITAILYKAGFFKRQYKEMLEEANGQFVSDGTPTPQVAQ
Protein: Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by amyloid-beta) (rLib) (Q8R5M3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8TF66}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L1
Sequence:
MPLKHYLLLLVGCQAWALGLAYYGCPSECTCSRASQVECTGARIVAMPTPLPWNAMSLQVVNTHITELPENLFLNISALIALKMEKNELSTIMPGAFRNLGSLRYLSLANNKLRMLPIRVFQDVNNLESLLLSNNQLVQIQPAQFSQFSNLRELQLHGNNLESIPEEAFDHLVGLTKLNLGRNSFTHLSPRLFQHLGNLQVLRLHENRLSDIPMGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISQLPPGIFMQLPQLNKLTLFGNSLRELSPGVFGPMPNLRELWLYNNHITSLADNTFSHLNQLQVLILSHNQLTYISPGAFNGLTNLRELSLHTNALQDLDSNVFRSLANLQNISLQSNRLRQLPGSIFANVNGLTTIQLQNNNLENLPLGIFDHLVNLCELRLYDNPWRCDSDILPLHNWLLLNRARLGTDTLPVCSSPANVRGQSLVIININFPGPSVQGPETPEVPSYPDTPSYPDTTSVSSTTEITSAVDDYTDLTTIEATDDRNTWGMTEAQSGLAIAAIVIGIIALACSLAACICCCCCKKRSQAVLMQMKAPNEC
Protein: Ras association domain-containing protein 1 (Q9NS23)
Organism: Homo sapiens (Human)
Function: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Subcellular location: [Isoform A]: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.; SUBCELLULAR LOCATION: [Isoform C]: Nucleus. Note=Predominantly nuclear.
Interaction partners:
- Serine/threonine-protein kinase 4
- Ras association domain-containing protein 5
- Serine/threonine-protein kinase 3
- GTPase HRas
- Microtubule-associated protein 1S
- GTPase KRas
- Protein salvador homolog 1
- GTPase NRas
- DNA repair protein complementing XP-A cells
- Death domain-associated protein 6
Sequence:
MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG
Protein: Protein ecdysoneless homolog (Q9CS74)
Organism: Mus musculus (Mouse)
Function: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (By similarity). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250|UniProtKB:O95905}.
Interaction partners:
- Protein AAR2 homolog
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Pre-mRNA-processing-splicing factor 8
Sequence:
MEGSGKLAMVEDAVEYHLFLIPDKARGTEEHREILQKYIERIMTQFAPILVPYIWQNQPFNLKYKPAKGGVPAHMYGMTKFGDNIEDEWFIVYVIKQITKEFPELVARVEDNDGEFLLIEAADFLPKWLDPDNSANRVFFHHGELCIIPVPRKSERIPWLPMTPPTIQQALSIISAHPEAVLASESIQAAVDRRVSGYPERVEASLHRAHCFLPAGIVAVLKQQPRLLSAAVQAFYLRDPIDLRACRVFKTFLPETRIMASVTFTKCLYAQLVQQKFVPDRRSGYGLPPPSHPQYRAYELGMKLAHGFEILCSKCSPHFSDSRKSLVTASPLWASFLESLKRNDYFKGLMDGSAQYQERLEMAKNYFQLSIHRPESSLAMSPGEEILTVLQTQPFDVAELKTEEADLPPEDDDQWLDLSPDQLDQLLQDAAGRKESQPGPQKEELQNYDVAQVSDSMKAFISKVSSHKGAELPRDPSEAPITFDADSFLNYFDKILGAKPQESDSEDDPGEEDVEGVDSDDDVGFEAQESESLKGALGSLKSYMARMDQELAHTSMGRSFTTRERLNKDPPSHTANDNSDEEDSGAGDCAVEAVDVDLNLISNILESYSSQAGLAGPASNLLHSMGVRLPDNADHNPQVSQ
Protein: Diadenylate cyclase (DAC) (EC 2.7.7.85) (Cyclic-di-AMP synthase) (c-di-AMP synthase) (A0A0H2UQU4)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MIVAYILYHFTKAIAGTKIMILVRGVLVFILAQILANMIGLTTISWLINQIITYGVIAAVVIFSPEIRTGLERLGRATDFFSNAPISAEEQMIRAFVKSVEYMSPRKIGALVAIQRVRTLQEYISTGIPLDAKISAELLINIFIPNTPLHDGAVIIKEERIAVTSAYLPLTKNTGISKEFGTRHRAAIGLSEVSDALTFVVSEETGGISITYNGRFKHNLTLDEFETELREILLPKEEVGLSFKERLLGGWKHEKK
Protein: Alpha-(1,3)-fucosyltransferase fut-5 (EC 2.4.1.65) (Fucosyltransferase fut-5) (G5EE06)
Organism: Caenorhabditis elegans
Function: Catalyzes the addition of fucose in alpha 1-3 linkage to GalNAc-beta-1->4-GlcNAc-beta-1->3-Gal-beta-1->4-Glc (LDNT)acceptor. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (M3F6) or GlcNAc-beta-1->2-Man-alpha-1->3-(GlcNAc-beta-1->2-Man-alpha-1->6)-Man-beta-1-4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (GnM3F6) acceptors.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000255|RuleBase:RU003832}; Single-pass type II membrane protein {ECO:0000255|RuleBase:RU003832}.
Interaction partners:
- Galactoside 2-alpha-L-fucosyltransferase
- Alpha-
Sequence:
MKHNTLRAVFQFSFFIGICTFIMIAGYSYQINYNQRMGIFYGGNITFKKVPKVVIYTATPFFDVPIENSILRDCSEKIKNSCTVTSNNKTFPIADAIVFHSRDINETKLSFFNKNRRYDIPYIMMAMENPFFAGLTVYHNFFNWTMTYRTDSDIFHPYGAFVKSYVPAEVNYSEIWNSKTKETLWMVSNGNAQNKRKELVEKLIKKGMSIDLYGQLYKKEPAECPRRRGPPGCDVKFHSPYKFAIAFENSNCKDYVTEKFWKKAGIYKTVPIVMSRKIYRDLGIPDSMYIAVDDYPNLEEFVHHIQNVTSNEEEYMKYHKWRKQFKIVDTNEGNIGFCQLCQKLAGYKRKLVPHKVYENLNSWHSTSTCDNSFATRFL
Protein: Putative metabolite transport protein YDL199C (Q12407)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Probable metabolite transport protein YDR387C
Sequence:
MKPPLNMSRSNKPLTQEANSSAHIDRAHQLAQDFNSKQDDTALTSLPHKNPDIFRFENNITAHSSRRGSLYRDSDATVVLPLSEHTPRLSMDDPYRQLLQQAEISQLRSKKKRHSSRVLRTSFISFVVLVSSLSGLDQGLISGNVMTLSFQKYFHYPLTSPLGNIVSIVNLGAFMASLFVYSGILEPCSRKKMLQISTMIYSLGAIVQVLALNQWCLLLGRFLLGVGMGFAFSMVIIYQFEFPLPCIRKRTLISIQCVSSVIAYSFGIWINCAFRYLGFAWRYPLSTHVALGIILNLMSFYLILESPSWLLKQKNDVEALVLISNVFDDGNFEENQTQLKFRVLKRDILLKSHLQKNSYPYAYILKDFSSIIKLLIGFQLLTRTNGVDAFLYYSPLILQQMGRGERKSIYLTGLNALIYSIVILAYVPLVLRKRKEKTNVLLGSIVMCALLFTISFTDWFPKSTTRYISILFAVFLFTHFISWDSIGWVMTIELLPHLSQAPVILLVSNFYWIFKWFVSLITPILIDRLSWKFYLIPSLSSFISIIFVLKIFPIETRDERLDSDDDSTGNGSGNHDDVFDDTGSEFSSSPSFSAYQINTLGSSIKQNNQAYSSIQNEQILPKNGNLSNQTHGSAQNVYFITSDSGPSRTGEFFSFHNRTDPNISDNIAANKPSSGGGQNSPGDMAVA
Protein: RNA-binding motif protein, Y chromosome, family 1 member F/J (Y chromosome RNA recognition motif 2) (Q15415)
Organism: Homo sapiens (Human)
Function: RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
Subcellular location: Nucleus.
Interaction partners:
- Proline-rich protein 3
Sequence:
MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGTSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSSGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNHRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREAYGSSSYVASIVDGGESRSEKGDSSRY
Protein: poly(A)-specific ribonuclease (EC 3.1.13.4) (Carbon catabolite repressor protein 4) (Cytoplasmic deadenylase) (Glucose-repressible alcohol dehydrogenase transcriptional effector) (Q9VCB6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRNKDKYDSANRRQQIFLSQEDIAAGKKTNWSGLEITGCVRNISPSLWEFEHLTALYLNDNQLLRLPADVGMLTSLRTLDLSSNKLRSLPAELGELIQLRELLLNNNFLRVLPYEIGKLFHLVILGLMGNPLQKEFMNIYNEPNGTQKLLTYMLDNLSFTVNPPPQRPWLPLAKPNKTRPACIFTVMCYNVLCDKYATRQMYGYCPSWALCWEYRKKSIIDEIRHYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYVDGCAIFFRASKFTLIKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPMSEVTQISQPLLVCTAHIHWDPEFCDVKLIQTMMLSNELKTIIDEASHSFRPGHKNDSNAVQLLLCGDFNSLPDSGVVEFLGKGRVSMDHLDFKDMGYKSCLQRLLSNDTNEFTHSFKLASAYNEDIMPHTNYTFDFKGIIDYIFYTKTGMVPLGLLGPVSNDWLRENKVVGCPHPHIPSDHFPLLVELELMHTASQQAPPNGLINRR
Protein: Cis-3-hydroxy-L-proline dehydratase (c3LHyp dehydratase) (c3LHypD) (EC 4.2.1.171) (D7A0Y2)
Organism: Ancylobacter novellus (strain ATCC 8093 / DSM 506 / JCM 20403 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIMB 10456) (Starkeya novella)
Function: Catalyzes the dehydration of cis-3-hydroxy-L-proline (c3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be involved in a degradation pathway that converts c3LHyp to L-proline, which would allow S.novella to grow on c3LHyp as a sole carbon source.
Interaction partners:
- Trans-3-hydroxy-L-proline dehydratase
- Mandelate racemase/muconate lactonizing protein
- Proline racemase
Sequence:
MKITGIKAWKVGLPLKEGRYNWSNGNFVEVFDSTVVAVETDAGITGYAECCPLGSAYLPAYAHGVRAGLEEIGPKVIGLDPTDLNVLNRHMDSVLRGHPYVKAPIDIACWDILGKVSGLPVYKLLGGAAQEKVALYRAISQEAPEAMARKIAGYKAEGYTKFQLKVGGDADQDIDRIRVTREILDATDTLVADANTGWTRAEAARIAAEVGDLDVYIEQPCPTYEECLSVRARTARPFVLDEVIDGVGTLMKALADDAMDIINLKISKVGGLTKARLMRDICVASGTPMTIEDTWGGDIVTATIAHLARSTPEEFSFSATDFNSYGTVDIAKGAPKRVNGFMTASDAPGLGIEPIFEVLGEPVVVIG