wanglab/gogpt-training-data huggingface dataset:
Protein: Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) (Q8IWW6)
Organism: Homo sapiens (Human)
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Interaction partners:
- Actin, alpha skeletal muscle
- Pleckstrin-2
- Pleckstrin
- Ras-related C3 botulinum toxin substrate 1
Sequence:
MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSKAFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPSSSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHFPGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTRDASISKGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERGHTLYTSDYTNEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTASSPKDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFGR
Protein: Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1) (P48995)
Organism: Homo sapiens (Human)
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11139478}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Short transient receptor potential channel 5
- Short transient receptor potential channel 4
- Stromal interaction molecule 1
- Polycystin-2
- Calcium release-activated calcium channel protein 1
- Transient receptor potential cation channel subfamily V member 4
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Short transient receptor potential channel 3
- Protein orai-2
Sequence:
MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN
Protein: Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2) (Q8TDN6)
Organism: Homo sapiens (Human)
Function: Required for biogenesis of the 60S ribosomal subunit.
Subcellular location: Nucleus, nucleolus.
Interaction partners:
- MKI67 FHA domain-interacting nucleolar phosphoprotein
- Probable rRNA-processing protein EBP2
- 60S ribosome subunit biogenesis protein NIP7 homolog
- GTP-binding protein 4
- Ribosome biogenesis protein WDR12
- Protein MAK16 homolog
- ATP-dependent RNA helicase DDX18
- Ribosomal L1 domain-containing protein 1
- mRNA turnover protein 4 homolog
- Nucleolar complex protein 3 homolog
Sequence:
MAATKRKRRGGFAVQAKKPKRNEIDAEPPAKRHATAEEVEEEERDRIPGPVCKGKWKNKERILIFSSRGINFRTRHLMQDLRMLMPHSKADTKMDRKDKLFVINEVCEMKNCNKCIYFEAKKKQDLYMWLSNSPHGPSAKFLVQNIHTLAELKMTGNCLKGSRPLLSFDPAFDELPHYALLKELLIQIFSTPRYHPKSQPFVDHVFTFTILDNRIWFRNFQIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPHYQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKKRIYKRQRKMKQRMDSGKTK
Protein: Large ribosomal subunit protein uL2cz/uL2cy (50S ribosomal protein L2, chloroplastic) (P0C496)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- 60S ribosomal protein L21
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL16c
- 60S ribosomal protein L29
- Small ribosomal subunit protein uS12cz/uS12cy
- Large ribosomal subunit protein uL5c
- 60S acidic ribosomal protein P1
- Uncharacterized protein
- Large ribosomal subunit protein bL33c
- KOW domain-containing protein
Sequence:
MAKHLYKTPIPSTRKGTIDRQVKSNPRNNLIHGRHRCGKGRNSRGIITARHRGGGHKRLYRKIDFRRNQKDISGRIVTIEYDPNRNAYICLIHYGDGEKGYILHPRGAIIGDTIVSGTKVPISMGNALPLTDMPLGTAIHNIEITRGRGGQLARAAGAVAKLIAKEGKSATLRLPSGEVRLVSQNCLATVGQVGNVGVNQKSLGRAGSKCWLGKRPVVRGVVMNPVDHPHGGGEGKAPIGRKKPTTPWGYPALGRRTRKRKKYSDSFILRRRK
Protein: Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) (O43159)
Organism: Homo sapiens (Human)
Function: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18485871}. Note=Localizes at rDNA locus.
Interaction partners:
- NAD-dependent protein deacetylase sirtuin-1
- Histone-lysine N-methyltransferase SUV39H1
- Importin subunit beta-1
- Ribosome production factor 2 homolog
- RNA-binding protein 28
- Pumilio homolog 3
- GTP-binding protein 4
- Probable rRNA-processing protein EBP2
- Ribosome biogenesis protein BRX1 homolog
- MKI67 FHA domain-interacting nucleolar phosphoprotein
Sequence:
MFEEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRARMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFKIVSKDLTNSHFFLFDFQKTGPPLVGPKAQLSGLQLQPCLYKRR
Protein: Leptin receptor (LEP-R) (OB receptor) (OB-R) (CD antigen CD295) (Q62959)
Organism: Rattus norvegicus (Rat)
Function: Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P48357}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P48357}. Basolateral cell membrane {ECO:0000250|UniProtKB:P48357}.; SUBCELLULAR LOCATION: [Isoform E]: Secreted {ECO:0000305}.
Interaction partners:
- Leptin
- Tyrosine-protein kinase JAK2
- Suppressor of cytokine signaling 3
- Tyrosine-protein kinase JAK3
- Interleukin-6
- Pro-opiomelanocortin
- Tyrosine-protein kinase
- Insulin-2
- Insulin-1
- 30 kDa adipocyte complement-related protein
Sequence:
MTCQKFYVVLLHWEFLYVITALNLAYPTSPWRFKLFCAPPSTTDDSFLSPAGVPNNTSSLKGASEALVEAKFNSTGIYVSELSKTIFHCCFGNEQGQNCSALTGNTEGKTLASVVKPLVFRQLGVNWDIECWMKGDLTLFICHMEPLLKNPFKNYDSKVHLLYDLPEVIDDLPLPPLKDSFQTVQCNCSVRECECHVPVPRAKVNYALLMYLEITSAGVSFQSPLMSLQPMLVVKPDPPLGLRMEVTDDGNLKISWDSQTKAPFPLQYQVKYLENSTIVREAAEIVSDTSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSLPQLFTTQDVMYFPPKILTSVGSNASFCCIYKNENQTISSKQIVWWMNLAEKIPETQYNTVSDHISKVTFSNLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDNPSIRPTSELKNCVLQTDGFYECVFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITINTGLLKVSWEKPVFPENNLQFQIRYGLNGKEIQWKTHEVFDAKSKSASLPVSDLCAVYVVQVRCRRLDGLGYWSNWSSPAYTLVMDVKVPMRGPEFWRIMDGDITKKERNVTLLWKPLMKNDSLCSVRRYVVKHRTAHNGTWSQDVGNQTNLTFLWAESAHTVTVLAINSIGASLVNFNLTFSWPMSKVNAVQSLSAYPLSSSCVILSWTLSPNDYSLLYLVIEWKNLNDDDGMKWLRIPSNVNKYYIHDNFIPIEKYQFSLYPVFMEGVGKPKIINGFTKDDIAKQQNDAGLYVIVPIIISSCVLLLGTLLISHQRMKKLFWDDVPNPKNCSWAQGLNFQKPETFEHLFTKHAESVIFGPLLLEPEPVSEEISVDTAWKNKDEMVPAAMVSLLLTTPDSTRGSICISDQCNSANFSGAQSTQGTCEDECQSQPSVKYATLVSNVKTVETDEEQGAIHSSVSQCIARKHSPLRQSFSSNSWEIEAQAFFLLSDHPPNVISPQLSFSGLDELLELEGNFPEENHGEKSVYYLGVSSGNKRENDMLLTDEAGVLCPFPAHCLFSDIRILQESCSHFVENNLNLGTSGKNFVPYMPQFQSCSTHSHKIIENKMCDLTV
Protein: Ethylene-responsive transcription factor RAP2-6 (Protein RELATED TO APETALA2 6) (Q7G1L2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator involved in the regulation of plant development and tolerance to abiotic stresses. Binds to the GCC-box pathogenesis-related promoter element and the cis-element CE1 (coupling element 1). Involved in the regulation of gene expression in response to abiotic stresses, possibly through the abscisic acid (ABA) signaling pathway. Involved in resistance to the beet cyst nematode Heterodera schachtii in roots. May promote callose deposition at syncytia which may interfere with nutrient import into syncytia and inhibit the development of nematodes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366, ECO:0000269|PubMed:20193749}.
Interaction partners:
- At5g40690
- 50S ribosomal protein L33
Sequence:
MVSMLTNVVSGETEPSASATWTMGHKREREEFSLPPQPLITGSAVTKECESSMSLERPKKYRGVRQRPWGKWAAEIRDPHKATRVWLGTFETAEAAARAYDAAALRFRGSKAKLNFPENVGTQTIQRNSHFLQNSMQPSLTYIDQCPTLLSYSRCMEQQQPLVGMLQPTEEENHFFEKPWTEYDQYNYSSFG
Protein: Protein HPH1 (Functionally related to TCP1 protein 1) (High pH protein 1) (Q99332)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Calcineurin-dependent protein required for growth under high NaCl, alkaline pH and cell wall stress.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12514182, ECO:0000269|PubMed:15189990}; Single-pass membrane protein {ECO:0000269|PubMed:12514182, ECO:0000269|PubMed:15189990}. Note=Punctate foci at the endoplasmic reticulum membrane. The distribution of FRT1 on the endoplasmic reticulum membrane depends on CaCl2 and calcineurin activity.
Interaction partners:
- Serine/threonine-protein phosphatase 2B catalytic subunit A1
Sequence:
MNLLIDRMENPGSRNCTLLPPSFPRGFCKGRRASSGDAVKIKESGLQPQPQPEPLQAKTNVAHFSKSSSRLPVIAVNDNPVVPRPSTEVNLGSLLQKEREKEKEEQPALHDRRHLYVTKNRAHGVRQRSLEMTSLPVLGSTKTGKFSDFLFEDDIDNRVGRHSRSYSGASSLDDPFRVSPKTDFNSNRARLSCLSKGRRGSMSVFQSCHTGLAFNQIQGSSSSQRRSSAGSFDYERKRLVNQFLQPSLGNSDPFDTLRESVVFEPSSTAGGIKLGNMHSQSQISVNSSPSTSLFYHDLDGSAVNDSSSFLYSRSNVPAFLSSSAFSSTSSTSSDSEDVDRRSLNGVYPSLGYLTNQRKPRNSSGSSTAPGTDTLGFKYLLNRQKSADSSTRFKSVLKVNNNNGSAATPDSSSNSISKSNSNLNDNIDELNYYQNHISTLLVKIENEMRRNLNDTIIKNENNVQKTIQKYDLLSGELTLLLDEMTTLRTTVINQFLVKLKSDFDEDDNKAFINELKISVEESVAQLQGLERRMEVCQERLNKQKSSLREMDSLIELKNVLNKSKNNTKSIYLYRYFIIDIIAFLLMGGFIVYVKNLLTRFFTR
Protein: Zinc finger transcription factor family protein 17 (P45972)
Organism: Caenorhabditis elegans
Function: Probable transcription factor. Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage.
Interaction partners:
- C3H1-type domain-containing protein
- HMG box domain-containing protein
- C2H2-type domain-containing protein
- Putative T-box protein 39
- Putative T-box protein 11
- Nuclear hormone receptor family member nhr-19
Sequence:
MLRYQASVYGDSYGNDYHLPVQGPSTIASSNGLRSQQSKIIKRPPTNYKSIPACRLAPRRRLFVADGNGVQKSMTSSSGVTFPPPDYMKKMKENYESGKIIYIRRNNPGMKGNQMTGRLTTINSSIRAPSYHATSMSAGSVTLDTSGSAPKYVYRLPKAEYGNKFDENRPASNMYVPAQEPPKQHFTTVPACMSMGGEVVFEEELDDEIADLGADELTGDGFNADKSPKSESPDPYLKSSGPLVQPCMTSKSPSYNLLQRNRLQTSRFACPQQDCFWRGTNEMSMKKHMLVHGPKQPVIYDKTGEAMKVQLVQPKPKGVKCSECDTFAYSRPLLLRHMYDSHGIEAPLVKRTFANREMLQSWLDSLRETHAVEFVVSSGSKKWGRGLQVHYLTCSRSGDQKERPNKKYVRPPRPSIKCGRNCMAYLKIKQNPTVSELQIEGCLHHSGHEIDHTRMVLESNELASIGAIVDAVNEGVDVLGNVETIRSYLGSSGRFRLVTENGLIEQMPIWFEQYHRDMAAFNGTGYRNNSGPIPITNPYLSMTMKPSINGNRRLPYSGMTIKKELESITMKKAVPIRFNGGQLQNLEMNSSIEEYDESKVKIEMDDEDALATQSILKDDFEEFKTEDLFGLGGGDDEILCGGEEASGVTSNIDGILAANLPDNFNDPLCGMDLATDFSGPFDDDVFDELLGLTNFNDRHNNLNIS
Protein: At1g19900/F6F9_4 (Glyoxal oxidase-related protein) (Q93Z02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Expressed protein
- Calcium-dependent lipid-binding family protein
- Ricin B-like lectin EULS3
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Nicotinamide adenine dinucleotide transporter 1, chloroplastic
- DNA repair endonuclease UVH1
- Haloacid dehalogenase-like hydrolase
- Succinate--CoA ligase subunit alpha-2, mitochondrial
- DEAD-box ATP-dependent RNA helicase FANCM
- DEAD/DEAH-box RNA helicase family protein
Sequence:
MAARATFIFYALFLTTLQFLLTHHVSSAARGLWKYIAPNVGISAMHMQLLHNDRVVMYDRTNFGPSNISLPNGNCRDNPQDAVSKIDCTAHSIEYDVATNTIRPLTVQSNTWCSSGSVRPDGVLVQTGGDRDGELKTRTFSPCNNNQCDWVEMNNGLKKRRWYASNHILPDGKQIVMGGQGQFNYEFFPKTTNPNVVALPFLAETHDQGQENNLYPFVFMNTDGNLFMFANNRAILLDYVKNTVVKTFPAIPGGDPRNYPSTGSAVLLPLKNLEADNVETEVLVCGGAPKGSYNLARKKTFVKALDTCARIKINDAKPEWAVEKMPHARVMGDMIPLPNGDVLLINGGSFGTAAWELGRTPVLAPDLYHPENPVGSRFESLRPTTIPRMYHSAAILLRDGRVLVGGSNPHAFYNYTGVLFPTELSLEAFSPVYLQREFSNLRPKIISPEPQSMIKYGTNLKLKFSVTGEVTTPAKVTMVFPTFTTHSFAMNQRVLVLDNVKFTRKGKSPMYEVQVRTPRSANIAWPGYYMIFVVNQDIPSEGVWVKLE
Protein: Peptidyl-prolyl cis-trans isomerase 9 (PPIase cyp9) (EC 5.2.1.8) (Cyclophilin 9) (Rotamase cyp9) (O74942)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-splicing factor spp42
- Plasma membrane fusion protein prm1
- Pre-mRNA-splicing factor cdc5
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor brr2
- Peptidyl-prolyl cis-trans isomerase cyp6
- Pre-mRNA-splicing factor cwf4
Sequence:
MMDGASPVDRDVSPVGLPKKRIKQNHDQVFLHNLPDAPRYTKSYMHNAEIYKCFPTKSNYILSVSYDGYVKFWHKTPNGVEYIKEFHAHNAMLLSAELSQDERLFITGADDKSLKVFDVESIDLVNIIDLEFLPKAICCFNSPSLKTSLIAVSSAESPLIFFFESGGDGEVLYTVKKHTAPVHCLRYLSTLDCFLSIDIGGMVEYWSPEEPFQKPDTAELFNMKSQTDLYIFKKQKSVPTSLEVSHFENFWSTISYPDCKVRVFDTKSGRAILELDENPSNAAKKVEALFEKEDTESSYYMSHVELGRRIAIERDIEKHGLTVGTTAIFDESEKYLLYGSIVGIKVVSIDNGTVVRIYGKDEAVRFTRLSLYQQAPKKSNLPSLDVIASNNPLVEESFQKDPTLFATAWKKQRFYLFSNMSTKFTLSDRDVYNEQVLPVTNNEGRQENGNILLGKAAIIHTTQGDISIKLYPEEAPKAVQNFTTHAENGYYDNTIFHRIIKNFMIQGGDPLGDGTGGESIWKKDFEDEISPNLKHDRPFTVSMANSGPNTNGSQFFITTDLTPWLDGKHTIFARAYAGLDVVHRIEQGETDKYDRPLEPTKIINISIVYT
Protein: Uridine 5'-monophosphate synthase (UMP synthase) (Rudimentary-like protein) [Includes: Orotate phosphoribosyltransferase (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)] (Q01637)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Dihydroorotate dehydrogenase
- Dihydropyrimidine dehydrogenase [NADP
- Uridine kinase
- Uridine phosphorylase
- GH09623p
- FI09636p
- Uracil phosphoribosyltransferase homolog
- Trifunctional purine biosynthetic protein adenosine-3
- Multifunctional protein r
- Uncharacterized protein, isoform B
Sequence:
MVAQNSDKMRALALKLFEINAFKFGDFKMKVGINSPVYFDLRVIVSYPDVMQTVSDLLVEHIKDKQLSAKHVCGVPYTALPLATIVSVQQGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVTSGSSILDTVRDLQGEGIVVTDAVVVVDREQGGVANIAKHGVRMHSLFTLSFLLNTLHEAGRIEKSTVEAVAKYIAAVQINSDGTFVGGDKGDVVRANDLQRTKLTYENRANLAKSAVAKRLFNLIASKQTNLCLAADLTHADEILDVADKCGPYICLLKTHVDIVEDFSDKFIADLQALAQRHNFLLMEDRKFADIGNTVSLQYGKGIYKISSWADLVTAHTLPGRSILQGLKAGLGEGGAGKERGVFLLAEMSASGNLIDAKYKENSNKIATEGADVDFVAGVVCQSSDAFAFPGLLQLTPGVKIDEGVDQLGQQYQSPEHVVKERGADIGVVGRGILKASSPKQAAQTYRDRLWAAYQDRVAK
Protein: Mitochondrial pyruvate carrier 2 (MPC2) (P38857)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mediates the uptake of pyruvate into mitochondria.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095}. Mitochondrion inner membrane {ECO:0000269|PubMed:22628558}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial pyruvate carrier 1
Sequence:
MSTSSVRFAFRRFWQSETGPKTVHFWAPTLKWGLVFAGFSDMKRPVEKISGAQNLSLLSTALIWTRWSFVIKPRNILLASVNSFLCLTAGYQLGRIANYRIRNGDSISQLCSYILSGADESKKEITTGR
Protein: Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Q9U2H1)
Organism: Caenorhabditis elegans
Function: Modulates cilium assembly.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:29420175}. Note=Localizes to the ciliary transitional zone in head and tail neurons. {ECO:0000269|PubMed:29420175}.
Interaction partners:
- TMEM
- Protein XRP2
- Kinesin-like protein
- TMEM
- Transmembrane protein 231
- Nephrocystin-1-like protein
- Transmembrane protein 237 homolog
- NePHronoPhthisis
Sequence:
MDKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIFSNWILRIRQDESTPTGLTSKRSPNYLPLLNGNSNNLVSKNFSLQGGNHGNNNNNGNGINRNFLPTIS
Protein: NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) (NADH dehydrogenase subunit 5) (P03915)
Organism: Homo sapiens (Human)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
Sequence:
MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT
Protein: Ropporin-1A (Cancer/testis antigen 91) (CT91) (Rhophilin-associated protein 1A) (Q9HAT0)
Organism: Homo sapiens (Human)
Function: Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9ESG2}. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. {ECO:0000250|UniProtKB:Q9ESG2}.
Interaction partners:
- A-kinase anchor protein 3
- Rhophilin-1
- Sperm surface protein Sp17
- Calcium-binding tyrosine phosphorylation-regulated protein
- Ropporin-1B
Sequence:
MAQTDKPTCIPPELPKMLKEFAKAAIRVQPQDLIQWAADYFEALSRGETPPVRERSERVALCNRAELTPELLKILHSQVAGRLIIRAEELAQMWKVVNLPTDLFNSVMNVGRFTEEIEWLKFLALACSALGVTITKTLKIVCEVLSCDHNGGSPRIPFSTFQFLYTYIAKVDGEISASHVSRMLNYMEQEVIGPDGIITVNDFTQNPRVQLE
Protein: Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnesyl diphosphate specific) (EC 2.5.1.88) (Cis-prenyltransferase) (Dodecaprenyl diphosphate synthase) (Q47RM6)
Organism: Thermobifida fusca (strain YX)
Function: Catalyzes the synthesis of Z,E-mixed prenyl diphosphates by a condensation of isopentenyl diphosphate to an allylic diphosphate. It shows a large substrate specificity accepting dimethylallyl diphosphate (DMAPP), GPP, E,Efarnesyl diphosphate (FPP), E,E,E-geranylgeranyl diphosphate (GGPP), neryl diphosphate (Z-GPP), and (2Z,6E)-farnesyl diphosphate (Z,E-FPP) as allylic substrates. The enzyme exhibits the highest activity when Z,E-FPP is employed as an allylic substrate. The major product is dodecaprenyl diphosphate (C60) under every allylic substrate conditions, but the enzyme is also able to synthesize even C70 prenyl diphosphate as the maximum chain-length product.
Interaction partners:
- 
- DNA repair protein RecO
- Phosphatidate cytidylyltransferase
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase
- SGNH hydrolase-type esterase domain-containing protein
- Trans-hexaprenyltranstransferase
- Putative polyprenyl synthase / dimethylallyltranstransferase
Sequence:
MSPKTVFSTDTHREPIPPQPHPSGARPPQLPRELIPRHVAIVMDGNGRWAKQRGLPRTEGHKAGESSLFDVIEGALELGVPYLSAYAFSTENWKRSPDEVRFLMGFNRDVIRRRRDELHARGVRVRWAGRPGRLWKSVIKELTEAEELTKHNTKLTLQFCVNYGGRAEIADAAAALARDVAAGRLSPNRVTEATLARYLYHPDIPDVDLFIRSSGEQRLSNFLLWQSSYAEFVFLDTLWPDFDRRHFWQACEIYARRDRRYGGAEPNPVGPPQSAAGAQGQD
Protein: Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit SOH1) (Q8VYB1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 7a
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 10a
- Mediator of RNA polymerase II transcription subunit 7b
- Mediator of RNA polymerase II transcription subunit 22a
- Mediator of RNA polymerase II transcription subunit 22b
Sequence:
MASPEEMGDDASEIPSPPKNTYKDPDGGRQRFLLELEFIQCLANPTYIHYLAQNRYFEDEAFIGYLKYLQYWQRPEYIKFIMYPHCLYFLELLQNPNFRTAMAHPANKELAHRQQFYYWKNYRNNRLKHILPRPLPEPVPPQPPVAPSTSLPPAPSATAALSPALSPMQYNNMLSKNDTRNMGATGIDRRKRKKGI