wanglab/gogpt-training-data huggingface dataset:
Protein: Syntaxin 16 (A0A8I6AQ84)
Organism: Rattus norvegicus (Rat)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Interaction partners:
Sequence:
MATRRLTDAFLLLRNNSIQNRQLLAEQLADDRMALVSGISLDPEAAIGVTKRSPPKWVDGVDEIQYDVGRIKQKMRELASLHDKHLNRPTLDDSSEEEHAIEITTQEVTQLFHRCQRAVQALPSRARRTCSEQEERLLRNVVASLAQALQELSTSFRHAQSDYLKRMKNREERSQHFFDTPVPLMDDGDDATLYGQGFTDDQLVLVEQNTLVVEEREREIRQIVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNVEQSCVKTEDGLKQLHKSCPPPCHRNPLILLVL
Protein: Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Q9VZ04)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648, ECO:0000256|RuleBase:RU368089}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648, ECO:0000256|RuleBase:RU368089}.
Interaction partners:
- Glucosidase II subunit alpha
- GH11935p
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- dolichyl-diphosphooligosaccharide--protein glycotransferase
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- alpha-1,2-Mannosidase
- ADP-ribosylation factor GTPase-activating protein 1
Sequence:
MARNTGSSSGSTPAASSSGSSAAAAAAAAAAAAAASNAKQKQRSPRFSLSSNLILDKWKTMIGCVCLAIASYFGYLGYLETRVNTPFDHQKMVVHAGLEQPDRYWGSYRPLTYFGMKTRDPHSLVMGLMWYTPSNLGPGGQGIRHWCEQGDKLDSYGWTHHDGRSFGVQEIQDLPFELKTSFVKYPEGKQYGGDWTARISVRNTTRAWDKSISLIWYVALDERTNGHIKYVSDDKSPEPGVYGEAQGLGEFQVRFHAVKGKILHKSYLSTVAPSLAKLKDTLFSHFRAFADKRGNRFIGLPGEIVSQNGLPSSNPEPNFIAIQITAEVDFTLDITYQSTSGFSLGESIPKPPTGRAYQDSLQAKIAQFEQRFEDRFQLKQKGHSPEEVRFARNALSNLLGGIGYFYGSSRVQSVYTKNPVPYWKAPLYTAVPSRSFFPRGFLWDEGFHGLLISAWDIDIELDIICHWFDLLNVEGWIPREQILGVEALAKVPEEFVTQRNSNANPPTFFLTLKKLLTSHRAELSQNGRLATLERLYPRVQAWFNWFNTTQRGEVLGTYLWRGRNATTTRELNPKSLSSGLDDYPRASHPTDKERHLDLRCWIALAAGVMAELSTLLGKDDAKYYETASYLTDNVRLNRLHLAPYSEQYADWGLHTDQVKLKRPPSMAPQQQQRHHHQHYQLPEMQRVTGELPTYQFVDSAFGYVSLFPLLLEQLDHDSPYLTKLLNDLRDPEQLWTNYGLRSLSKRSPLYMQRNTEHDPPYWRGPIWININYLAAKALHHYGKIDGPNAALARQIYAELRDNLVGNILRQYKRSGYLWEQYDDTSGEGKGCNPFTGWTATVVLLMAEQF
Protein: Receptor expression-enhancing protein (E2QRG8)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|RuleBase:RU362006}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362006}. Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004326}.
Interaction partners:
Sequence:
MSAPRPGALFLLSCAVGADGGAPAGGRVDGGVIGLVALYLVFGYGASLLCNLIGFGYPAYISIKAIESPNKEDDTQWLTYWVVYGVFSIAEFFSDIFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYKRIIRPFFLKHESQMDSVVKDLKDKAKETADAITKEA
Protein: Nudix hydrolase 9 (D6RAW2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSGSNGSKENSHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYKPVEYTAVSVLAGPRWADPQISESNFSPKFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRWKRDSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNSLQKTSAEKREIEEKLHKL
Protein: Peroxynitrite isomerase Rv2717c (EC 5.99.-.-) (Ferric Arabidopsis thaliana nitrobindin) (At-Nb(III)) (O64527)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Heme binding protein
Sequence:
MNQLQQLQNPGESPPVHPFVAPLSYLLGTWRGQGEGEYPTIPSFRYGEEIRFSHSGKPVIAYTQKTWKLESGAPMHAESGYFRPRPDGSIEVVIAQSTGLVEVQKGTYNVDEQSIKLKSDLVGNASKVKEISREFELVDGKLSYVVRMSTTTNPLQPHLKAILDKL
Protein: Homeobox protein Hox-B5 (Homeobox protein H24.1) (Homeobox protein Hox-2.1) (Homeobox protein Mu-1) (P09079)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-B6
- Homeobox protein Hox-B7
- Homeobox protein Hox-B2
- Homeobox protein Hox-B4
- Homeobox protein Hox-C4
- Homeobox protein Hox-B3
- Homeobox protein Hox-B8
- Pre-B-cell leukemia transcription factor 1
- Pre-B-cell leukemia transcription factor 3
- Homeobox protein Hox-D4
Sequence:
MSSYFVNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSSASSSHFGAVGESSRAFPASAQEPRFRQATSSCSLSSPESLPCTNGDSHGAKPSASSPSDQATPASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP
Protein: Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (Tyrosine-protein kinase receptor EPH-2) (P09759)
Organism: Rattus norvegicus (Rat)
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively (By similarity). Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P54762}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P54762}. Early endosome membrane {ECO:0000250|UniProtKB:P54762}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8CBF3}.
Interaction partners:
- Ephrin B2
- Ephrin-B1
- Ephrin-B3
- Ephrin-A5
- Ephrin-A4
- Ephrin-A1
- Ephexin-1
- Ras GTPase-activating protein 1
- Tyrosine-protein kinase
- Tyrosine-protein kinase.
Sequence:
MALDCLLLFLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKAGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPSEASPICTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGVTLAGHQKKILSSIHSMRVQMNQSPSVMA
Protein: RNA helicase (EC 3.6.4.13) (B2C6E9)
Organism: Trichosurus vulpecula (Brush-tailed possum)
Interaction partners:
Sequence:
RARSGEMGDEDWDAEIINPHISSLVPVFEKDRYSSGANGDTFNRASASSDIDGPSKRENTSTMGGFGAGKGFGNRGFSSSRFEEGDSSGFWRESNDYEDNQTRSRGFSRRGGYQDGNNSEASGSSRRGGRGSFRGCRGGFGHGRPNSESEQEDGPQRTGGLFGSRRTVLVEAGNGDNFRGRSVGGRGGYKGLNEEVVAGSGRNPWKSETEGGESGDIQGPKVTYIPPPPPENEEATFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEETDLCQTLNNDITKAGYTKLTPVQKYGIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMRDGVTASRFKDQQEPECIIVAPTRELINQIFLEARKFSFGTCVRPVVIYGGTQLGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLGQIRYLVLDEADRMLDMGFGPEMKKLISFPGMPSKEQRQTLMFSATFPRGNFKDWAGEFLKNLTICLVAVGQVGGACSDVQQTVLQVGQYSKREKLVEILRNIGEERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRCGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGKAISFFDPEPDSHLAQPLVKVLSDAQQGCPCMGRKKCFQYICPWLQWGYFKGEMCLPQLNNSEKLPRQEQHEPLVGFSSAQVPKSN
Protein: Long neurotoxin MS5 (P86099)
Organism: Micrurus surinamensis (Surinam coral snake)
Function: Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Very weak inhibitor of the endogenous nicotinic acetylcholine receptors (nAChR) in the human rhabdomyosarcoma TE 671 cell line. This neurotoxin is lethal to zebrafish by injection at the back of the dorsolateral region, but is not toxic to mice by intraperitoneal injection.
Subcellular location: Secreted {ECO:0000269|PubMed:18384102}.
Interaction partners:
Sequence:
LTCHTCPYNTCANSETCPAGKNICYQKKWEEHRGERIERSCVANCPEFESSHTSLLCCTTANCD
Protein: Large ribosomal subunit protein eL33z (60S ribosomal protein L35a-2) (Q9FZH0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein eL38z/eL38y
- At1g43860
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL29z
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein eL29y
Sequence:
MKGRQGERVRLYVRGTVLGYKRSKSNQYPNTSLIQIEGVNTQEEVNWYKGKRLAYIYKAKTKKNGSHYRCIWGKVTRPHGNSGVVRSKFTSNLPPKSMGARVRVFMYPSNI
Protein: Nucleoporin NUP57 (Nuclear pore protein NUP57) (P48837)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP57 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
Interaction partners:
- Nucleoporin NUP159
- Nucleoporin NUP157
- Nucleoporin NUP192
- Nucleoporin NUP2
- Nucleoporin NUP100/NSP100
- Nucleoporin NUP42
- Nucleoporin NSP1
- Nucleoporin NIC96
- Nucleoporin NUP49/NSP49
- Nucleoporin NUP145
Sequence:
MFGFSGSNNGFGNKPAGSTGFSFGQNNNNTNTQPSASGFGFGGSQPNSGTATTGGFGANQATNTFGSNQQSSTGGGLFGNKPALGSLGSSSTTASGTTATGTGLFGQQTAQPQQSTIGGGLFGNKPTTTTGGLFGNSAQNNSTTSGGLFGNKVGSTGSLMGGNSTQNTSNMNAGGLFGAKPQNTTATTGGLFGSKPQGSTTNGGLFGSGTQNNNTLGGGGLFGQSQQPQTNTAPGLGNTVSTQPSFAWSKPSTGSNLQQQQQQQIQVPLQQTQAIAQQQQLSNYPQQIQEQVLKCKESWDPNTTKTKLRAFVYNKVNETEAILYTKPGHVLQEEWDQAMEKKPSPQTIPIQIYGFEGLNQRNQVQTENVAQARIILNHILEKSTQLQQKHELDTASRILKAQSRNVEIEKRILKLGTQLATLKNRGLPLGIAEEKMWSQFQTLLQRSEDPAGLGKTNELWARLAILKERAKNISSQLDSKLMVFNDDTKNQDSMSKGTGEESNDRINKIVEILTNQQRGITYLNEVLEKDAAIVKKYKNKT
Protein: Phosphoglucan phosphatase DSP4, chloroplastic (EC 3.1.3.-) (AtPTPKIS1) (Dual specificity protein phosphatase 4) (Protein STARCH-EXCESS 4) (AtSEX4) (Q9FEB5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Starch granule-associated phosphoglucan phosphatase involved in the control of starch accumulation. Acts as major regulator of the initial steps of starch degradation at the granule surface. Functions during the day by dephosphorylating the night-accumulated phospho-oligosaccharides. Can release phosphate from both the C6 and the C3 positions, but dephosphorylates preferentially the C6 position.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:16513634, ECO:0000269|PubMed:16623901, ECO:0000269|PubMed:16772378}. Note=Associated with starch granule.
Interaction partners:
- Isoamylase 3, chloroplastic
- Alpha-glucan water dikinase 1, chloroplastic
- Phosphoglucan phosphatase
- 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic
- 4-alpha-glucanotransferase DPE2
- Alpha-glucan phosphorylase 2, cytosolic
- Protein PTST, chloroplastic
- Alpha-glucan phosphorylase 1
- SNF1-related protein kinase catalytic subunit alpha KIN11
- Isoamylase 2, chloroplastic
Sequence:
MNCLQNLPRCSVSPLLGFGCIQRDHSSSSSSLKMLISPPIKANDPKSRLVLHAVSESKSSSEMSGVAKDEEKSDEYSQDMTQAMGAVLTYRHELGMNYNFIRPDLIVGSCLQTPEDVDKLRKIGVKTIFCLQQDPDLEYFGVDISSIQAYAKKYSDIQHIRCEIRDFDAFDLRMRLPAVVGTLYKAVKRNGGVTYVHCTAGMGRAPAVALTYMFWVQGYKLMEAHKLLMSKRSCFPKLDAIRNATIDILTGLKRKTVTLTLKDKGFSRVEISGLDIGWGQRIPLTLDKGTGFWILKRELPEGQFEYKYIIDGEWTHNEAEPFIGPNKDGHTNNYAKVVDDPTSVDGTTRERLSSEDPELLEEERSKLIQFLETCSEAEV
Protein: Uncharacterized protein (Q389F4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTISSPCNHEYHLWTLFKLHSKPLGAVTSGAHHGRYLTEDGFRAIVDSLVGMGLLDGGHVAEREGTESRSDKSVGAVVLYGEVEIATVPSTSPRANASTESAGVSGEDALERVDISLSMDSAPICSLPHPNVVISEVVPPVRLQSETKSFGDTIVPDAESHATAELPASPWQVDKAEPEGSGWKQGMEPREDTVHRGVHGMRMPSDNGNRHQLPENMTERSKEQVQNTDVRRRLVDSYVSGDSRQSQKCVQWTRRGGAVYPNNHLRSGVEGETSSFNGTGLDAVISLVKSDKTSCFSDMALDSAALDQLLPRSVENDALDKANDNMFVMIEEAAAQQDSLHGFSRVKFFPAENTANRPDIRNRGPRLSTPPRRPRNPAVILPSPHVSITDERYKRPGASPRPSQSSFRSPRLSPNNRGSSVRFHPSTSFQTPVGRHGGEGTGDGLAAAATKTGTRGAAFVGPRASMDEERTALSEDVNTDERRQVQQLMPRRSINTSGSGSCGYTSRGSEGFPQPPGRRMVGGVTSLESAQPRHLPRNAVGSTQDGMGMGSAVALPQYRRKALLTSDATSADHTFGEWSSLSPQGVMHHGACAPFRGSNTNSSLSGGQGSGTMTSDPRRFVARPAVGPTAPLPLLLGPRGRRRSASVPCCPHGTEPSPRPPRSLSKRARLRAERKWRPMEPPAVPHTRARSWGFRAGGNVTAPLIPTWE
Protein: Probable RNA-binding protein ARP1 (ABA-regulated RNA-binding protein 1) (Q9M1S3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable RNA-binding protein involved in the regulation of abscisic acid (ABA) response during seed germination. May regulate transcript levels of several germination-responsive genes under ABA.
Subcellular location: Nucleus {ECO:0000269|PubMed:23040517}.
Interaction partners:
- AT5g37360/MNJ8_150
- MEI2 C-terminal RRM only like 1
- Proline-rich protein 4
Sequence:
MTTSNNVNGCFGDTKLTKVFVGGLAWDTHKEAMYDHFIKYGDILEAVIISDKLTRRSKGYGFVTFKDAKAATRACEDSTPIINGRRANCNLASLGGRLRKSPTMTSPQQGPKNGNRATPPHVGNHSQWYYPSGFTNQQHQQQNHQAVPFYGYPSAYVAPNMTFNQKVGYVGGTYMNGYYAQMQPQPQSQPQPQYYHHHMYGGGRVMVGAASPMVPFYTVYPYHQSQAIGFPQPSFSKPLSFSTPPISGTVGGESIQKKAIH
Protein: Prostate and breast cancer overexpressed gene 1 protein (Protein UROC28) (UC28) (Q9GZY1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11156405}. Nucleus {ECO:0000269|PubMed:11156405}.
Interaction partners:
Sequence:
MRAFLRNQKYEDMHNIIHILQIRKLRHRLSNFPRLPGILAPETVLLPFCYKVFRKKEKVKRSQKATEFIDYSIEQSHHAILTPLQTHLTMKGSSMKCSSLSSEAILFTLTLQLTQTLGLECCLLYLSKTIHPQII
Protein: tRNA (cytidine(56)-2'-O)-methyltransferase (EC 2.1.1.206) (tRNA ribose 2'-O-methyltransferase aTrm56) (Q9UYD1)
Organism: Pyrococcus abyssi (strain GE5 / Orsay)
Function: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Methylase
- SAM-dependent RNA methyltransferase
- Transglutaminase-like domain-containing protein
- Archaetidylinositol phosphate synthase
- Nicotinamide-nucleotide adenylyltransferase
- Ribosomal RNA small subunit methyltransferase Nep1
- Hydroxide adenosyltransferase
Sequence:
MIVVLRLGHRPERDKRVTTHVALTARAFGADGIIIVSEEVDLKVKESVEDVVERWGGPFFVKFEKSWRKVMKEFDGVKVHLTMYGIHIDDIIDELREKLREGRDFMVIVGAEKVPREVYELADYNVAIGNQPHSEVAALAVFLDRLLEGKGLRKEFKGAKLKIIPQARGKMVVEVQKDAKQAEASGEGASRKNGQLPS
Protein: Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) (Protein post-translational modification mutant A) (Q94502)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from N-linked oligosaccharides on newly synthesized glycoproteins.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:9397534}. Golgi apparatus {ECO:0000250}.
Interaction partners:
- Glucosidase 2 subunit beta
- Mannosyl-oligosaccharide glucosidase
- Calnexin
- 4-alpha-glucanotransferase
- Counting factor 50
- Probable UDP-glucose:glycoprotein glucosyltransferase A
- J domain-containing protein
- J domain-containing protein
- Large ribosomal subunit protein uL2m
Sequence:
MRKLVILIILSIVCSLFIGSIESVDTSKFKTCKDSHFCKRNRVSHEVGVMNEMKSKQNFNIVEGSIKLVKQENTIYFDLQEQNQKSNLLTMKLEIYEGGIVRMRAQEKEPLLNKQRYQVQDVLLDTIKTVPIQWKQEPSKQSNTFSFKHGEKECCYVLVQLVPFKLDVYIMNELAITTNSDNLFHFEPISDKPQPLPPKEKKSEEENKEANQEEDNNNNNNDNNEEQQVSTEGYWEERFGSHQDSKPNGPMSIGMDFTFVGSSHVYGIPEHTTRLSLKSTTGNGINEQPYRLYNLDVFEYEIDKTMALYGHVPLMISHDTKKTVGVFWLNAAETFVDIEDVTTPVSPSKKTHWISESGIIDVFYLTGPTPSTIFKQYAYLTGTTALPQMFSLGYHQCKWNYKSEDDVKQVDNGFDENHIPYDVIWLDIEHTDGKRYFTWDNNNFPTPADMQNIIGAKHRKMVTIVDPHIKRDNNYYVHSEATSKGYYIKNKDGNDYDGWCWPGSSSYLDFTNPEIRKWWATQFGYDKYKGSTPNLYIWNDMNEPSVFNGPEVSMHKDAKHHGGFEHRDVHNLYGYYYHMASADGLVQRNADQNDRPFVLSRAFYAGSQRIGAIWTGDNSAQWSHLEISNPMLLSMNLAGITFSGADVGGFFGNPDAELLTRWYQAGAFQPFFRGHAHLDSRRREPWLFNEPYTTIIREAIVKRYSYLPLWYTTFYQNTLNGAPVMRPLWVQYPKEANLFDVDDHYLIGDSLLVKPVTQQSCKTMKVLLPGQSVNEIWYDVDTEKPINAGVIEIDTPLEKIPVYQRGGSIISKKERVRRSTYQMRDDPYTIRIALDSSKSAQGQLYIDDEHSFDYKKGKFLYRQFTFKDNVLSFSDASNKSSTSYKPNVTIEKIVILGVQKPHSITCNITGKEKLSFEYDSTLSKLTIRKPDLLVDTDFIIKLN
Protein: Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) (Q01094)
Organism: Homo sapiens (Human)
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Directly activates transcription of PEG10. Positively regulates transcription of RRP1B.
Subcellular location: Nucleus {ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:28992046}.
Interaction partners:
- Histone deacetylase 1
- Retinoblastoma-associated protein
- Cyclin-A1
- Transcription factor Dp-1
- Cyclin-A2
- Transcription factor Dp-2
- Cyclin-dependent kinase 2
- Myc proto-oncogene protein
- Forkhead box protein O3
- Retinoblastoma-like protein 1
Sequence:
MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF
Protein: Uncharacterized HTH-type transcriptional regulator Rv0081 (P9WMI7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable oxidoreductase
- Uncharacterized protein Rv0083
- Possible formate hydrogenase HycE
- Uncharacterized protein Rv0085
- Possible hydrogenase HycQ
- Possible formate hydrogenlyase HycD
- DNA-binding transcriptional activator DevR/DosR
- Uncharacterized protein Rv0080
- Dormancy associated translation inhibitor
- Uncharacterized protein Rv0088
Sequence:
MESEPLYKLKAEFFKTLAHPARIRILELLVERDRSVGELLSSDVGLESSNLSQQLGVLRRAGVVAARRDGNAMIYSIAAPDIAELLAVARKVLARVLSDRVAVLEDLRAGGSAT
Protein: Protein phosphatase (A6MUT0)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
PAYVRLLRDNEAEVRIAAAGKVTKFCRILNPELAIQHILPCVKELSTDSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALCMQWLKDKVYSIRDAAANNVKRLAEEFGPDWAMQHIVPQVLDVINNPHYLYRMTILHAISLLAPVMGSDITCSKLLPVVINASKDRV
Protein: N-sulfoglucosamine sulfohydrolase (EC 3.10.1.1) (Sulphamidase) (Q9JHK6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MHCPGLACCTILLVLGVCGAHSRNVLLIVADDGGFESGVYNNTAIATPHLDALSRHSLIFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVQSLPLLLNQAGVRTGIIGKKHVGPETVYPFDFAFREENSSVMQVGRNITRIKQLVQKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGYIPDWTPQIYDPQDVMVPYFVPDTPAARADLAAQYTTIGRMDQGVGLVLQELRGAGVLNDTLIIFTSDNGIPFPSGRTNLYWPGTAEPLLVYSPEHPQRWGQVSDAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIQLTGRSLLPALEAEPLWATVFSSQSHHEVTMSYPMRSVYHQNFRLIHNLSFKMPFPIDQDFYVSPTFQDLLNRTTTGRPTGWYKDLHRYYYRERWELYDISRDPRETRNLAADPDLAQVLEMLKAQLVKWQWETHDPWVCAPDGVLEEKLTPQCRPLHNEL
Protein: Gene 7 protein (Q716G8)
Organism: Shigella phage Sf6 (Shigella flexneri bacteriophage VI) (Bacteriophage SfVI)
Interaction partners:
Sequence:
MATVLTKGEIVLFALRKFAIASNASLTDVEPQSIEDGVNDLEDMMSEWMINPGDIGYAFATGDEQPLPDDESGLPRKYKHAVGYQLLLRMLSDYSLEPTPQVLSNAQRSYDALMTDTLVVPSMRRRGDFPVGQGNKYDVFTSDRYYPGDLPLIDGDIPNA
Protein: Fibroblast growth factor (FGF) (Q5TLE2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Fibroblast growth factor receptor 1-A
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor 3
- Vascular endothelial growth factor receptor kdr-like
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor receptor, beta polypeptide
- Fibroblast growth factor receptor.
- receptor protein-tyrosine kinase
- Mast/stem cell growth factor receptor kita
Sequence:
MNVPLLLFLLFQLPRSAQLTGRERAYLEHQLVEEGRVSGRRTGRLYCRVGIGFHLQIHIDGRVNGSHEPDSLSVLELFAVSQGVIGIRGVFSNRFLAMNKRGRLHATESFTDDCKFRERFQENSYNTYASVIHKNHRTGREWFVALNKRGKAKMGSSPRVKSQHVSTHFLPRMNLHEKTEQGFTVTDKEEEKQPPPHPSKPSLPKVNTAKKNRPIVKYWPKFRFG