wanglab/gogpt-training-data huggingface dataset:
Protein: Thioredoxin (Trx) (P11232)
Organism: Rattus norvegicus (Rat)
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P10599}. Cytoplasm {ECO:0000250|UniProtKB:P10599}. Secreted {ECO:0000250|UniProtKB:P10599}. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Secreted by a leaderless secretory pathway. {ECO:0000250|UniProtKB:P10599}.
Interaction partners:
- Thioredoxin-interacting protein
- mitogen-activated protein kinase kinase kinase
- Thioredoxin reductase 1, cytoplasmic
- Peroxiredoxin-2
- Peroxiredoxin-5, mitochondrial
- Thioredoxin, mitochondrial
- Peroxiredoxin-1
- Mitochondrial peptide methionine sulfoxide reductase
- Thioredoxin reductase 2, mitochondrial
- Superoxide dismutase
Sequence:
MVKLIESKEAFQEALAAAGDKLVVVDFSATWCGPCKMIKPFFHSLCDKYSNVVFLEVDVDDCQDVAADCEVKCMPTFQFYKKGQKVGEFSGANKEKLEATITEFA
Protein: Large ribosomal subunit protein eL19 (60S ribosomal protein L19) (O02639)
Organism: Caenorhabditis elegans
Interaction partners:
- Ribosomal Protein, Small subunit
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein eS27
Sequence:
MSNLRLQKRLASAVLKCGKHRVWLDPNEVSEISGANSRQSIRRLVNDGLIIRKPVTVHSRFRAREYEEARRKGRHTGYGKRRGTANARMPEKTLWIRRMRVLRNLLRRYRDAKKLDKHLYHELYLRAKGNNFKNKKNLIEYIFKKKTENKRAKQLADQAQARRDKNKESRKRREERQVVKRAELLRKISQSEKVIAGK
Protein: T. brucei spp.-specific protein (Q57W15)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLDLFASLVEQHFMCRFPTRSHWPGPHRHSSGDKMVEESNNKSKTKKEEMLEPKGPDKEASSSALFPVDMLELTQGTTVRSSTLPIMQQMQQSSFSWSQLPNFVGDTDSPCKQSPSIRWDWSAARTAAERVPQKTNTQGLRECKQLQPQGEGHFSSVIHHRQGNHSLHLTVHHGWHSAVTTARANIRQEQTNVPQGLLMYRAPPCTSFFPQFESVVNSTTHGDMDFSTSIPQLGPLQDGLGSVTDPTLYSTHEQMMNSETCHSRTVGYITLGSNDTNRKYGDEDASKQYIGIGSEVVIPTVVPNTIESLQGTTNTIKEGTLLQSSRLICLEDSGYGGGEAQEIPLKHVNSPRRRRTAECTYCLYERPLHCDARDGSDEYRPEFYVGLDDDYHQDYKVFDALSIVTTSSCCFGMGMKGLKPPETSENVQRFLTLINRCSSTDGDSDGEREVTVVTDGGEADPAFPVEFLTMPHKEEAPLQLLPSSSTTDSKHVSFARIGNAKPPASYAFEEFVYAEKLKAKQENSLAVSKHIKEARAAYDISNQVPAHDAPLVFGNYPTVTRETARMSHGGCSQHMWTRNQGSDEVASPHFWRRGSDEAGEQRREIHTFVRRWLEEVHEATVVTQHKG
Protein: Exocrine gland secreted peptide 34 (G3UXG0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MFKNQKPRVTLQSNHFAWNSRLCITSASEFKLLKSPLHKERRNPKELEKQRRVKQKLKSCETINRVSAMASFPVMCFLLILLLPSMFTEGVVLKKDQEELIDSEDESIILISCQYIQEFLKNAGEILFYSNDKEVMFEKIIDRDFFFFVFV
Protein: Uncharacterized protein C3C7.01c (O14127)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase ptn1
- Phosphoinositide 3-phosphatase
- Phosphatidylinositol 4-kinase pik1
- Phosphatidylinositol 4-kinase stt4
- Phosphatidylinositol 4-kinase lsb6
- Inositol-1,4,5-trisphosphate 5-phosphatase 2
- Phosphatidylinositol 4-phosphate 5-kinase its3
- Inositol-1,4,5-trisphosphate 5-phosphatase 1
- Uncharacterized protein C19F5.03
- 1-phosphatidylinositol 3-phosphate 5-kinase fab1
Sequence:
MNQDVRVFPDSIYLSCSKKKASLRIDRVDGCLSLSNSLDLSKTPDYNNVQLYGFIRLKIYKYVVLVTSCDLHAAILGNNIYRARKFAIFPITRTLPFSTGLLNIKDEEELHYISLLNKHLSKGQILFSPTLDLTCSLQRLRVLTQSFELTSKYNYRFFWNKYAFHELIELTNKDLGFQEWIQPMIQGNIAITNSFLKTYNLRLCVITRHSPDYAGTRYFTRGVNAQGSAANFNEIEQIIMIESPITLEEQMVLSFTQIRGSIPMFWAEVNDLHYRPLLSLQPLDYSETVFGKHFQELANDYGDNLVVVNLLDQKGREAPLRSGFEKLCKRNKNPPLSYVYYDYHKQGSRNLPLFLAEIQSLLIEGKYYAEHGSKTTAMQTNFVRTNCMDCLDRTNVIQTSIAQFILNMQLHDIGVLSSSESLEEYDSFLQDFRLIWANTGDYISDLYTGTPALKGDVTRHGTRTIFGAFKDLLNCFRRYILNNFFDGMLQDSYDLGLGVFRPYDSLSIPDLPLRFHWTRFVAPGIFLFTTIILTIQELFGNPSLFCRLLYSIPMVNAGIYLYFHRRQYVNWPRLVLPTYAKGGWFSFRNHFRNITLKVFRFLRSGSFKKSV
Protein: Adaptor-related protein complex 3 beta 1 subunit (Q3MNE1)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
Sequence:
MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVSNEKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKE
Protein: Reticulophagy regulator 2 (Q8NC44)
Organism: Homo sapiens (Human)
Function: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress. When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins. Required for collagen quality control in a LIR motif-independent manner (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:34338405}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Gamma-aminobutyric acid receptor-associated protein
- 60S ribosomal export protein NMD3
Sequence:
MASGGGGGNTGAGGGPGMGLSLGLGLGLSLGMSEATSEAEEEAATAEAVGRLATTLWLRLRGWEAVLAAAQRLLVWEKPLHSLVTAAALNGLFWLLSSSSLRPFFLLSVSLLAYFLLDLWQPRFLPDVSASSPEEPHSDSEGAGSGARPHLLSVPELCRYLAESWLTFQIHLQELLQYKRQNPAQFCVRVCSGCAVLAVLGHYVPGIMISYIVLLSILLWPLVVYHELIQRMYTRLEPLLMQLDYSMKAEANALHHKHDKRKRQGKNAPPGGDEPLAETESESEAELAGFSPVVDVKKTALALAITDSELSDEEASILESGGFSVSRATTPQLTDVSEDLDQQSLPSEPEETLSRDLGEGEEGELAPPEDLLGRPQALSRQALDSEEEEEDVAAKETLLRLSSPLHFVNTHFNGAGSPPDGVKCSPGGPVETLSPETVSGGLTALPGTLSPPLCLVGSDPAPSPSILPPVPQDSPQPLPAPEEEEALTTEDFELLDQGELEQLNAELGLEPETPPKPPDAPPLGPDIHSLVQSDQEAQAVAEP
Protein: Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) (Q5VWG9)
Organism: Homo sapiens (Human)
Function: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF3 forms the TFIID-A module together with TAF5 and TBP. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process.
Subcellular location: Nucleus {ECO:0000269|PubMed:11438666}.
Interaction partners:
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 4
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 9
Sequence:
MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVGEAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASGASAKAPVRSVVTETVSTYVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMTAPPEEMQWFCPKCANKKKDKKHKKRKHRAH
Protein: Always early (Q2PNP5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRHQLKKPRKMVAAWQNDELFIKRPNFAPRIRISEKPEIQGRIKPGVASKRTENFTKKPSNISVDVSEDEKAKEKEKEQDPYSNDFILGKRLYNFLKYLSSHRWIWCEFVDSFLDKPTLTMGYDMKRFIAEYCPLLHSCFMPRRGWQLVRRNMGKARRFSAAFIELEREELECQRRIVRQLQQHKFNPKEHVGYLDQIPKRVPLPLAKDATVSSFLHGNSFEGIVNGTVMGYDPQDYTYLVRFNRDDNAVVLSLPDSQLYSDEETAAVPLSIIMRGNKSSSVISESAKTEKFGNKRYTKELLESVLRVGKLQDVKHKILMDLARMNEDFETFKEIGSSSSRRDAKVTPQRENLQRRYSASMITLHRVXADILEPLRILHDYLVEYQKQDEEEESKRGRPASEVYQKCRMQAEQDLKTAADEKFLKIESDRTQEFVRNLHTILYLNGKLGRENSSNLETIIADLVTHMVDNIQPSLGRKLKDGVDSLEPLRQQVVQIFKDVKKPERFQITQQAPMQTEDGIYNFVVEAQPDTPS
Protein: Secretion pathway protein Sls2/Rcy1, putative (AFU_orthologue AFUA_1G02050) (C8VTT1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Exocyst complex component exo84
- Exocyst complex component SEC15
- Exocyst complex component Sec8
- Exocyst complex protein exo70
- Exocyst complex component SEC5
- Exocyst complex component Sec6, putative
- E3 ubiquitin ligase complex SCF subunit sconC
- Uncharacterized protein
- Rab GTPase SrgA
- Ras GTPase similar to RAB11B
Sequence:
MSKARNGPRTGTKPRRDVLASLKMASMEEISRASLPAEIMASILDHLSPIDLIRAARASKLLREMAYDDSRWVQRLKRIGCWDEAEARKNAEEKFGTIANRASVELQDSTVAQQVPSQPKIDVTPISDGFDQINLSASAANDVVDLDTDPVLGALKLARSIRGEARQEYGKIHAALAPFYDDIATLGPSPENLLFQRYTEPQQQAQILSQLQAFARCDTTTGCENRHENLRAAVSMFETAALKEFRHGYETDDIDGRMKNYAHVLYTLNGGGSASELFTHHNHIITRKAELGQTNDCIDTLTQKVKLHQTQAFFTRLSVAFNEEVSIINRAFPPALQLAQPFVEKVGRDVLYPFLTAIFDELHRSNKEEYLVSVSSTFAQCMNLCDNLLPIQNSLDTFEDLLHQTIAQVYEPHMDLYLAEELDFFRKGSEASVAEWDRQLSEQAASTESFLLSNVNRQADKRDFLTSFKKVIMAPVNILPSFSNKSSEQQKPDRDSLAGDSGSTPRANRFSTISSPGTPPIQEAPTTELAAKAAIMKSKLEGIRSLFSIEVALGLVHAAKSSLERAARFMAIGGETGAAVKQQCEAIFVALLRILGHGHLIKGFDKAVDHLSDYRPREQGDRDQSGVEPLVTFLELVNVGDLILQMIDVFYEQEMIGSNITDRNDFLDPAVKEKKKFEQNLDERVAAGLNKGIDVLMEEVDYILATRQLATDFNPDVSTDPHRKTMDVSVTEAAAAVVDVVSSHTQMLVGSTDKSTLDVFNQEVGLRLFTALCKHLKRQRISIEGSLKLISDMNHYFKFIQRLKNNELLIYFKAFRELSQIYLIDSSDAKELANFIADAGRFSGIWRVEEVYEFAERRADWYQIKRDVERAMYGIGCNVM
Protein: Forkhead box protein A2 (Axial protein) (Q07342)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system.
Subcellular location: Nucleus.
Interaction partners:
- SRY-box containing gene 17
- One cut domain family member
- T-box transcription factor T-A
- T-box transcription factor Tb.
- Homeobox protein Nkx-2.2a
- GATA-binding protein 6
- GATA-binding protein 4.
- Sonic hedgehog protein
- NK6 homeobox 1.
- Paired box protein Pax-6
Sequence:
MLGAVKMEGHEHAADWSTYYGEPECYTSVSNMNTGLGMNSMNTYMTMSGMSSTANMTAANTMNMSYVNTGMSPSMTGMSPGTGAMAGMGAGMTGMSAALSPTMSPMAAQAPSMNALTSYSNMNAMSPMYGQSNINRSRDPKTYRRSYTHAKPPYSYISLITMAIQQSPSKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCDKKLSKDPSRKTSEGGSNSSSESCNGNESPHSNSSSNELKRSLSDMKSGQGLSPDHAASPTSQAQHLLAQHHSVLAHEGHLKPEHHYSFNHPFSINNLMSSEQQHHKMDLKTYEQVMHYGYGSPMAGTLSMGSMASKAGLDSPDTSYYQGVYSRPILNSS
Protein: Receptor-mediated endocytosis protein 6 (Q9GYH7)
Organism: Caenorhabditis elegans
Function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits.
Subcellular location: Membrane {ECO:0000269|PubMed:15895077}; Peripheral membrane protein {ECO:0000269|PubMed:15895077}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:15895077}.
Interaction partners:
- small monomeric GTPase
- FYVE-type domain-containing protein
- Vacuolar protein sorting-associated protein 29
- FYVE-type domain-containing protein
- Probable clathrin heavy chain 1
- PH domain-containing protein
- UDENN domain-containing protein
- NF-kappa-B inhibitor-interacting Ras-like protein 1
- Translation initiation factor eIF2B subunit beta
- Endocytosis protein RME-8
Sequence:
MADIIERIRSQDEYREFYELATKIRNQKLLTDAELHSLNRHQQEVSDNEIKLLTEAWRSSYWNNVGRQLKNQALEPTIACRLLKEISETEALPAYKHVGHHFSTLDQLLTILYNEPQSVAELLNSIDRNDITSNDSTIQVLFHLVYSCALYPEDELKIAQVVCNLLKLQLYRSGSEMRTILRKETSISTRFYKHFVELIHPTMVYLTKALRKGVLDVIQLGSFWLDIDAKQSTARFLRDNKQNEDRLPEYRALVVSKLVDFVDTFLENISKALPMLPPNLNWIIRDIFCSLYEVVDDVSAIELSHACKDMIVSNLICPAIISPQKFGVVDNDVRVGTIVNHNLVQIAMIIQMISLREFESPPEEYKEFLSQCRNTHLISEMMDALLVEKLAPDVEITSLIANGTAESDMATKSSFVGTVADVNVLIKIIRNAPSTSDAKLSRILSVCDKLPATISSTTQKSHFDNLEASPKISTLRNIHRKVQHSFKRTGDSFNDINELGAKQGEALAFGKENFDLFYLEYSPKNYKDVAEADRLKKKAEERRQLADLEKLLEPTPAPKETPVENNLIDFSSGSAETNSEHLSDSTSVSPEPLTSTEELQIGDQGVGGEQRGKLAKLKSLSDRMKKGITQSNTLSDIREHLRRSGSFVKPPPSGIPTSSSEQNLPDVATGPRDDILAKYASISSIKEQKPALGNLIDGTASASSTPRKEPLEPYYSSENLVGCRAFQDTLRKMITVLGNISYLPRIGYRNETKQNEWDKKVLLGRFLDGVLVETEHRREYGLAAQLREVKRCIELFEHAGVEILMDHLKLNEAEQDKIVNGMREERASLMRKSNDISSLEQRVLLNRRLTEQILVDFLMRTFLETGFNNKHTVGKTQEVTAVLKFYDEFKYLRAQDERAEFLKNLLTFLRDRLMQNVDWNFATDTMMSRAMTTIERYVIFAVYDNAFYPNRDADHHRDKLLRGTIAKVSDVVTPVNDFLKIPEHLHGEAPWPSAQAELSMLDIYVTAQDKLNCVVRCCDVINNLVALSSKNAVASADDLTPVLVFVIIKANPRALLSNVQFVETFAGDRIESGRDAYYWVNFKSAVEYIKTIL
Protein: UDP-glycosyltransferase 74C1 (EC 2.4.1.-) (Q9SKC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytochrome P450 83A1
- Methylthioalkylmalate synthase 3, chloroplastic
- Dihomomethionine N-hydroxylase
- Hexahomomethionine N-hydroxylase
- Methylthioalkylmalate synthase 1, chloroplastic
- Cytosolic sulfotransferase 18
- Methionine aminotransferase BCAT4
- 3-isopropylmalate dehydratase small subunit 3
- Cytosolic sulfotransferase 17
- Probable sodium/metabolite cotransporter BASS5, chloroplastic
Sequence:
MSEAKKGHVLFFPYPLQGHINPMIQLAKRLSKKGITSTLIIASKDHREPYTSDDYSITVHTIHDGFFPHEHPHAKFVDLDRFHNSTSRSLTDFISSAKLSDNPPKALIYDPFMPFALDIAKDLDLYVVAYFTQPWLASLVYYHINEGTYDVPVDRHENPTLASFPGFPLLSQDDLPSFACEKGSYPLLHEFVVRQFSNLLQADCILCNTFDQLEPKVVKWMNDQWPVKNIGPVVPSKFLDNRLPEDKDYELENSKTEPDESVLKWLGNRPAKSVVYVAFGTLVALSEKQMKEIAMAISQTGYHFLWSVRESERSKLPSGFIEEAEEKDSGLVAKWVPQLEVLAHESIGCFVSHCGWNSTLEALCLGVPMVGVPQWTDQPTNAKFIEDVWKIGVRVRTDGEGLSSKEEIARCIVEVMEGERGKEIRKNVEKLKVLAREAISEGGSSDKKIDEFVALLT
Protein: Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (Q8I6Z9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Nodulation protein E
- Beta-ketoacyl-ACP synthase III
- Acetyl-CoA carboxylase
- 3-oxoacyl-[acyl-carrier-protein] reductase
- Enoyl-acyl carrier reductase
- Acyl carrier protein
- Acyl carrier protein, mitochondrial, putative
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
- Ribosomal protein S16, mitochondrial, putative
- GTPase Era, putative
Sequence:
MQVIFLHSLTFIIFTVLLILILPSYCFIIKDSKIINDTWKYENKENTNKIGSYRKKLRHNVSVNKDIKGNEHIMSSYENEKYIKKLLEDYEKYKITTYSSEYTFFFPGQGEQYMSMGLDTYNNYKECKELYNDASKILGYNLMDMIKNGPIEKLKNSEVAQPSIYTVSMASLEKLKIENNDAYMKLNLCMGYSLGEYAALTCANSLSFDDGVYLTKERGKAMQYCSTLYNMTTVAIVGLTLDNIKKLIEDVNHKMNDDIFIVSYMTDRKFGLCGKPESMDYLNTLAKEKYKAIFTKKLEIAGAFHSFYMFPAKETLKNVLNQITFKKLSVPVISNVDGNAYDDPVIIKDLLILQLTSPIKINTCLQNVLKHGYKSGYELGPGTINTNLLRDISKNTKRTIPYI
Protein: Prolyl 4-hydroxylase subunit alpha (Prolyl 4-hydrolase) (EC 1.14.11.-) (Q86KR9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the post-translational formation of 4-hydroxyproline. Probably hydroxylates skp1 on Pro-143.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Putative mediator of RNA polymerase II transcription subunit 16
- UDP-galactose:fucoside alpha-3-galactosyltransferase
- [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase
- Bifunctional glycosyltransferase pgtA
- Elongin-C
- Cullin-2
- Cullin-5
- Cullin-1
- SCF ubiquitin ligase complex protein SKP1b
- DDRGK domain-containing protein 1
Sequence:
MDISNLPPHIRQQILGLISKPQQNNDESSSSNNKNNLINNEKVSNVLIDLTSNLKIENFKIFNKESLNQLEKKGYLIIDNFLNDLNKINLIYDESYNQFKENKLIEAGMNKGTDKWKDKSIRGDYIQWIHRDSNSRIQDKDLSSTIRNINYLLDKLDLIKNEFDNVIPNFNSIKTQTQLAVYLNGGRYIKHRDSFYSSESLTISRRITMIYYVNKDWKKGDGGELRLYTNNPNNTNQKELKQTEEFIDIEPIADRLLIFLSPFLEHEVLQCNFEPRIAITTWIY
Protein: Uncharacterized protein (Q38CJ4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSNRGFTPRAIIPPAAPSSRDKRPAGAPYGKNLNNAKATVPAQQRVQGLKQNQPANSHPLPCESCRELMKCTQDARQALEKVLQNARMIFLDDTLHHQMDDERWLRVLRALGGNKREYFTRIPSNCLTATDATL
Protein: Cell wall protein PRY3 (Pathogenesis-related protein 3) (P47033)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The full-length isoform (isoform Long) is a daughter cell-specific cell wall protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds. Involved in tolerance to organic solvents such as dimethyl sulfoxide (DMSO). Also plays a role as an inhibitor of mating. STE12 is utilized as a repressor of full-length PRY3 transcription, ensuring efficient mating.
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP). The short isoform lacks the predicted signal peptide and might have an alternate localization.
Interaction partners:
- Uncharacterized protein YGR050C
Sequence:
MLEFPISVLLGCLVAVKAQTTFPNFESDVLNEHNKFRALHVDTAPLTWSDTLATYAQNYADQYDCSGVLTHSDGPYGENLALGYTDTGAVDAWYGEISKYNYSNPGFSESTGHFTQVVWKSTAEIGCGYKYCGTTWNNYIVCSYNPPGNYLGEFAEEVEPLISTVSSSSSSSSSTSTTSDTVSTISSSIMPAVAQGYTTTVSSAASSSSLKSTTINPAKTATLTASSSTVITSSTESVGSSTVSSASSSSVTTSYATSSSTVVSSDATSSTTTTSSVATSSSTTSSDPTSSTAAASSSDPASSSAAASSSASTENAASSSSAISSSSSMVSAPLSSTLTTSTASSRSVTSNSVNSVKFANTTVFSAQTTSSVSASLSSSVAADDIQGSTSKEATSSVSEHTSIVTSATNAAQYATRLGSSSRSSSGAVSSSAVSQSVLNSVIAVNTDVSVTSVSSTAHTTKDTATTSVTASESITSETAQASSSTEKNISNSAATSSSIYSNSASVSGHGVTYAAEYAITSEQSSALATSVPATNCSSIVKTTTLENSSTTTITAITKSTTTLATTANNSTRAATAVTIDPTLDPTDNSASPTDNAKHTSTYGSSSTGASLDSLRTTTSISVSSNTTQLVSTCTSESDYSDSPSFAISTATTTESNLITNTITASCSTDSNFPTSAASSTDETAFTRTISTSCSTLNGASTQTSELTTSPMKTNTVVPASSFPSTTTTCLENDDTAFSSIYTEVNAATIINPGETSSLASDFATSEKPNEPTSVKSTSNEGTSSTTTTYQQTVATLYAKPSSTSLGARTTTGSNGRSTTSQQDGSAMHQPTSSIYTQLKEGTSTTAKLSAYEGAATPLSIFQCNSLAGTIAAFVVAVLFAF
Protein: Lung adenoma susceptibility protein 2 (I7GY12)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAKSKTKHRLCSQESSVSALLASCTLSGSNSSNSDGSFHYKDKLYRSASQALQAYIDDFDLGQIYPGASTGKINIDEDFTNMSQFCNYIYKPNNAFENLDHKKHSNFISCRRHTVNDIDSMSLTTDDLLRLPADGSFSYTYVGPSHRTSKKNKKCRGRLGSLDIEKNPHFQGPYTSMGKDNFVTPVIRSNINGKQCGDKIELLILKAKRNLEQCTEELPKSMKKDDSPCSLDKLEADRSWENIPVTFKSPVPVNSDDSPQQTSRAKSAKGVLEDFLNNDNQSCTLSGGKHHGPVEALKQMLFNLQAVQERFNQNKTTDPKEEIKQVSEDDFSKLQLKESMIPITRSLQKALHHLSRLRDLVDDTNGERSPKM
Protein: Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1) (Q9UIK4)
Organism: Homo sapiens (Human)
Function: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytic motility by controlling cell spreading and polarization.
Subcellular location: Cytoplasm. Cytoplasmic vesicle, autophagosome lumen.
Interaction partners:
- Calmodulin-1
- Beclin-1
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- Beclin-2
- Calmodulin-like protein 5
- Calmodulin-like protein 3
- Death-associated protein kinase 3
- Death-associated protein kinase 1
- Kalirin
Sequence:
MFQASMRSPNMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQYVRRRWKLSFSIVSLCNHLTRSLMKKVHLRPDEDLRNCESDTEEDIARRKALHPRRRSSTS
Protein: Prospero homeobox 1 (C9JU29)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKE
Protein: Flavin-dependent halogenase radH (EC 1.14.14.-) (Non-heme halogenase radH) (Radicicol biosynthesis cluster protein radH) (C5H881)
Organism: Floropilus chiversii (Chaetomium chiversii)
Function: Non-heme halogenase; part of the gene cluster that mediates the biosynthesis of radicicol, a resorcylic acid lactone (RAL) that irreversibly inhibits the HSP90 molecular chaperone, an important target for cancer chemotherapy. The cluster encodes only two apparent post-PKS enzymes, a cytochrome P450 monooxygenase (radP) and a non-heme halogenase (radH) that introduce the epoxide and the chlorine, respectively. If this cluster includes all the genes required for radicicol biosynthesis, the remaining structural features of radicicol are presumably generated by the PKSs rads1 and rads2. The C-2' ketone could arise if the R-PKS rads1 and NR-PKS rads2 each carry out four iterations, in contrast to the five iteration-three iteration split for the hypothemycin PKSs (By similarity). The origin of the cis 5',6' double bond is not known (By similarity). The radicicol R-PKS rads1 ER domain may catalyze either double bond isomerization or reduction in the third iteration (By similarity).
Interaction partners:
Sequence:
MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV