wanglab/gogpt-training-data huggingface dataset:
Protein: UDP-glycosyltransferase 79B30 (EC 2.4.1.239) (Flavonol 3-O-glucoside/galactoside (1->2) glucosyltransferase) (GmF3G2''Gt-a) (A0A0G4DBR5)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Flavonol 3-O-glucoside/galactoside (1->2) glucosyltransferase converting kaempferol 3-O-glucoside to kaempferol 3-O-sophoroside. Has a broad in vitro activity for kaempferol/quercetin 3-O-glucoside/galactoside derivatives, but cannot glucosylate kaempferol 3-O-rhamnosyl-(1->4)-[rhamnosyl-(1->6)- glucoside] and 3-O-rhamnosyl-(1->4)-[glucosyl-(1->6)-glucoside]. Has a higher preference for UDP-glucose than UDP-galactose, and no activity with UDP-arabinose and UDP-glucuronic acid. Represents probably a dominant allele of the gene.
Interaction partners:
- Polygalacturonase
Sequence:
MKSRPLHIAMYPWLAMGHQIAFLHLCNKLAIRGHKISFITPPKAQAKLEPFNLHPNSITFVTINVPHVEGLPPDAQTTADVTYPLQPQIMTAMDLTKDDIETLLTGLKPDLVFYDFTHWMPALAKRLGIKAVHYCTASSVMIGYTLTPARFHQGTDLMESDLMEPPEGYPDSSIKLQTHEARVFAAKRKDTFGSNVLFYDRQFIALNEADLLAYRTCREIEGPYMDYIGKQFNKPVVATGPVILDPPTLDLEEKFSTWLGGFEPGSVVYCCFGSECTLRPNQFLELVLGLELTGMPFLAAVKAPLGFETVESAMPEGFQERVKGRGFVYGGWVQQQLILAHPSVGCFITHCGSGSLSEALVNKCQLVLLPNVGDQILNARMMGTNLEVGVEVEKGDEDGMYTKESVCKAVSIVMDCENETSKRVRANHARIRELLLNKDLESSYVDSFCMRLQEIVEGI
Protein: 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (cAMP-specific phosphodiesterase 4B) (P14646)
Organism: Rattus norvegicus (Rat)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Subcellular location: [Isoform 4]: Cytoplasm {ECO:0000250|UniProtKB:Q07343}. Cell membrane {ECO:0000250|UniProtKB:Q07343}.
Interaction partners:
- Disrupted in schizophrenia 1 homolog
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Adenosine kinase
- GTP:AMP phosphotransferase AK3, mitochondrial
- Adenine phosphoribosyltransferase
- Deoxycytidine kinase
- Adenylosuccinate lyase
Sequence:
MKKSRSVMAVTADDNLKDYFECSLSKSYSSSSYTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSSGLVLHAAFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRIVRNNFTLLTNLHGAPNKRSPAASQAPVTRVSLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLMEKFQFELTLEEEDSEGPEKEGEGPNYFSSTKTLCVIDPENRDSLEETDIDIATEDKSLIDT
Protein: Chitinase-like protein Idgf3 (Imaginal disk growth factor protein 3) (Q8MLZ7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex.
Subcellular location: Secreted {ECO:0000269|PubMed:9847235}. Note=Secreted in hemolymph. It is probably transported to target tissues via hemolymph.
Interaction partners:
Sequence:
MTGSLWLSLALSLAVLAQFKVSAAPNLVCFYDSQGSQRQGLAQFSMIDIELALQFCTHLVYGYAGVNADNYEMQSINKRLDLEQRHLAQITSMKERYPHIKFLLSVGGDADTNEGNQYIKLLESGQQGHRRFIESARDLVRRYNFDGLDLALQLPRNKPRKVHGDVGSAWKSFKKFFTGDFIVDTESETHKGQVTALIKDLSAALKQNDLLLSLTVLPNVNSSWYYDAPSIAPSLDFINLGTFDFLTPQRNPEEADFSAPTYEAVGQNRLGHYNLNFQMEHWLLQRVPANKINIGIATYGRSWKMSKDSGDSGMPVVPSTQGPAPAGPQSKQEGLLNWAEICSLMPNPSNSNARGPNAPVKRVVDPTKRYGSYAFRAADENGDHGLWISYDDPDSASSKAMYARARNLGGVALFDLTQDDFRGQCTNDRFPMLRAIKYRLL
Protein: Glyceraldehyde-3-phosphate dehydrogenase 1 (GAPDH 1) (EC 1.2.1.12) (Q6FPW3)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Phosphoglycerate kinase
- Triosephosphate isomerase
- Fructose-bisphosphate aldolase
- Transketolase
- Glucose-6-phosphate isomerase
- Transaldolase
- Transaldolase
- Glucose-6-phosphate 1-dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase 2
- Enolase 1
Sequence:
MVRVAINGFGRIGRIVLRIAMKRDGIDVVAINDPFITNDYAAYMFKYDSTHGRYDGEVTHDDKDLIIDGKAIKCYQERDPADLPWGDNDIDIVIEATGVFTAKDLAEKHITAGAKKVVITGPSATAPMFVKGVNDDKYTSDVTVISNASCTTNCLAPLAKVLQDNFGIEEALMSTVHSQTATQKTVDGPSKKDWRGGRTASANIIPSSTGAAKAVTKVLPELEGKLTGMAFRVPTVDVSVVDLTVRFAKDVTYDEIKAAIKKASEGEMKGILAYTEDAVVSTDFLGDTHSSIFDASAGIQLSPRFVKLVSWYDNEYGFSARVVDMVELVSKA
Protein: Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3) (P48299)
Organism: Mus musculus (Mouse)
Function: Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular location: Secreted.
Interaction partners:
- Endothelin receptor type B
- Endothelin-1 receptor
- Endothelin-1
- Endothelin-2
- Kell blood group glycoprotein homolog
- Endothelin-converting enzyme 1
- Type-2 angiotensin II receptor
- Glial cell line-derived neurotrophic factor
- Endoplasmic reticulum membrane adapter protein XK
- Oxytocin receptor
Sequence:
MEPGLWLLLGLTVTSAAGLVPCPQSGDSGRASVSQGPPEAGSERGCEETVAGPGERIVSPTVALPAQPESAGQERAPGRSGKQEDKGLPAHHRPRRCTCFTYKDKECVYYCHLDIIWINTPEQTVPYGLSNYRESLRGKRSLGPVPESSQPSPWTRLRCTCMGADDKACAHFCARTRDVTSYSGRAERPAAEEMRETGGPRQRLMSRTDKAHRP
Protein: Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein) (Q5SW96)
Organism: Homo sapiens (Human)
Function: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12451172}.
Interaction partners:
- AP-2 complex subunit beta
- Low-density lipoprotein receptor
- Low-density lipoprotein receptor-related protein 2
- Apolipoprotein B-100
- Disabled homolog 2
- Clathrin heavy chain 1
- Proprotein convertase subtilisin/kexin type 9
- Vitamin D-binding protein
- Apolipoprotein E
- Cubilin
Sequence:
MDALKSAGRALIRSPSLAKQSWGGGGRHRKLPENWTDTRETLLEGMLFSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKEKRDKASQEGGDVLGARQDCTPSLKSLVATGNLLDLEETAKAPLSTVSANTTNMDEVPRPQALSGSSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLTAQDMHYAQCLSPVDWDKPDSSGTEQDDLFSF
Protein: Protein UL35 (P16766)
Organism: Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Function: Plays important role in immediate-early gene expression through interaction with UL82. Forms nuclear bodies in host nucleus, independently of PML. In turn, UL35 nuclear bodies associate with and remodel PML bodies. Through interaction with host DCAF1, causes cells to accumulate in the G2 phase of the cell cycle by inducing a DNA damage response. Regulates viral assembly by controlling the localization of the essential gB through regulation of a retrograde transport pathway. This modulation occurs via binding and inhibition of host sorting nexin 5/SNX5. Also plays a role in the inhibition of pattern recognition receptor-mediated type I interferon signaling at the level of TBK1.
Subcellular location: [Isoform UL35]: Virion tegument {ECO:0000269|PubMed:15452216}. Host nucleus {ECO:0000269|PubMed:11836424, ECO:0000269|PubMed:21489587, ECO:0000269|PubMed:22072767, ECO:0000269|PubMed:32466380}. Host cytoplasm {ECO:0000269|PubMed:21489587, ECO:0000269|PubMed:32466380}. Note=Found in nuclear bodies. {ECO:0000269|PubMed:21489587}.; SUBCELLULAR LOCATION: [Isoform UL35A]: Host nucleus {ECO:0000269|PubMed:11836424, ECO:0000269|PubMed:21489587}. Host cytoplasm {ECO:0000269|PubMed:21489587}.
Interaction partners:
Sequence:
MAQGSRAPSGPPLPVLPVDDWLNFRVDLFGDEHRRLLLEMLTQGCSNFVGLLNFGVPSPVYALEALVDFQVRNAFMKVKPVAQEIIRICILANHYRNSRDVLRDLRTQLDVLYSDPLKTRLLRGLIRLCRAAQTGVKPEDISVHLGADDVTFGVLKRALVRLHRVRDALGLRASPEAEARYPRLTTYNLLFHPPPFTTVEAVDLCAENLSDVTQRRNRPLRCLTSIKRPGSRTLEDALNDMYLLLTLRHLQLRHALELQMMQDWVVERCNRLCDALYFCYTQAPETRQTFVTLVRGLELARQHSSPAFQPMLYNLLQLLTQLHEANVYLCPGYLHFSAYKLLKKIQSVSDARERGEFGDEDEEQENDGEPREAQLDLEADPTAREGELFFFSKNLYGNGEVFRVPEQPSRYLRRRMFVERPETLQIFYNFHEGKITTETYHLQRIYSMMIEGASRQTGLTPKRFMELLDRAPLGQESEPEITEHRDLFADVFRRPVTDAASSSSASSSSSSASPNSVSLPSARSSSTRTTTPASTYTSAGTSSTTGLLLSSSLSGSHGISSADLEQPPRQRRRMVSVTLFSPYSVAYSHHRRHRRRRSPPPAPRGPAHTRFQGPDSMPSTSYGSDVEDPRDDLAENLRHL
Protein: 3-oxosteroid 1-dehydrogenase (EC 1.3.99.4) (Q06401)
Organism: Comamonas testosteroni (Pseudomonas testosteroni)
Function: Dehydrogenates steroids by introducing a double bond in steroid ring A.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:1657885}; Peripheral membrane protein {ECO:0000269|PubMed:1657885}.
Interaction partners:
Sequence:
MAEQEYDLIVVGSGAGACWAPIRAQEQGLKTLVVEKTELFGGTSALSGGGIWIPLNYDQKTAGIKDDLETAFGYMKRCVRGMATDDRVLAYVETASKMAEYLRQIGIPYRAMAKYADYYPHIEGSRPGGRTMDPVDFNAARLRVTALETMRPGPPGNQLFGRMSISAFEAHSMLSRELKSRFTILGIMLKYFLDYPWRNKTRRDRRMTGGQALVAGLLTAANKARVEMWCNSPLKELVQDASGRVTGVIVERNGQRQQINARRGVLLGAGGFERNQEMRDQYLNKPTRLVDGNPCGRQYGDAHRAGQAWAHTGADGLVLGRAHHGCSQGAGLSRHFRGTLAAGVHGGQRQGAALPQRVRPVSGIPAAMLAENAKGNGGVPAWIVFDASFRAQNPMGPLMPGSAVPDSKVRKSWLNNVYWKGRRWKIWRADRRGRAGLQVSARRMTEYARAGKDLDFDRGGNVFDRYYGDPRLKNPNLGPIEKGPFYAMRLWPGEIGTKGGLLTDREGRVLDTQGRIIEGLYCVGNNSASVMAPAYAGAGSTLGPAMTFAFRAVADMVGKPLPLENPHLLGKTV
Protein: Ornithine carbamoyltransferase (OTCase) (EC 2.1.3.3) (P0C0N0)
Organism: Staphylococcus epidermidis
Function: Has vitronectin and fibronectin-binding activity.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDL
Protein: anthranilate synthase (EC 4.1.3.27) (Q9FXK1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Anthranilate phosphoribosyltransferase, chloroplastic
- Anthranilate synthase alpha subunit 1, chloroplastic
- anthranilate synthase
- Anthranilate synthase alpha subunit 2, chloroplastic
- Aminodeoxychorismate synthase, chloroplastic
- Chorismate synthase, chloroplastic
- Isochorismate synthase 1, chloroplastic
- Isochorismate synthase 2, chloroplastic
- Protein PHYLLO
- Anthranilate phosphoribosyltransferase
Sequence:
MAESNSIPSVVINSSKQNGPIIVIDNYDSFTYNLCQYKQNFENCYLFLQYMGELQCHFEVYRNDELTVEELKRKNPRGVLISPGPGTPQDSGISLQTVLELGPLVPLFGVCMGLQCIGEAFGGKIVRSPFGVMHGKSSMVHYDEKGEEGLFSGLSNPFIVGRYHSLVIEKDTFPSDELEVTAWTEDGLVMAARHRKYKHIQGVQFHPESIITTEGKTIVRNFIKIVEKKDSEKLT
Protein: Outer surface protein B (P17739)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Subcellular location: Cell outer membrane; Lipid-anchor.
Interaction partners:
Sequence:
MRLLIGFALALALIGCAQKGAESIGSQKENDLNLEDSSKKSHQNAKQDLPAVTEDSVSLFNGNKIFVSKEKNSSGKYDLRATIDQVELKGTSDKNNGSGTLEGSKPDKSKVKLTVSADLNTVTLEAFDASNQKISSKVTKKQGSITEETLKANKLDSKKLTRSNGTTLEYSQITDADNATKAVETLKNSIKLEGSLVGGKTTVEIKEGTVTLKREIEKDGKVKVFLNDTAGSNKKTGKWEDSTSTLTISADSKKTKDLVFLTDGTITVQQYNTAGTSLEGSASEIKNLSELKNALK
Protein: ADP ribosylation factor-like GTPase 3, like 2 (ADP-ribosylation factor-like 3, like 2) (Q6PC43)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
- Protein unc-119 homolog B
- Protein unc-119 homolog A
- Protein unc-119 homolog B
- Protein XRP2
Sequence:
MGEAPKGLLSVMQKLKGSSELELRILLLGLDNAGKTTLLKSLASEDVNTITPTQGFNIKTVASRGMKLNVWDIGGQRKIRPFWKKYLENTDLLVYVIDSADKKRFEETGLELSELIDEENLCGVPVLIFANKQDLGTAAPASEIAEGLNLHTYRDRVWQIQACSAITGEGVQDGMNWICNNLVNRKK
Protein: Probable transcriptional regulator SLK2 (AtSLK2) (Protein SEUSS-like 2) (Q94BP0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription regulator that functions in the development of the carpel margin meristem similarly to SEUSS (SEU). In association with SEU, supports organ development from meristematic regions by facilitating auxin response and thus organ initiation, and by sustaining meristematic potential through the maintenance of PHABULOSA expression. DNA-binding adapter subunit of the SEU-SLK2 transcriptional corepressor of abiotic stress (e.g. salt and osmotic stress) response genes.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcriptional corepressor LEUNIG
- Transcriptional corepressor LEUNIG_HOMOLOG
- CLK4-associating serine/arginine-rich protein
- Protein GRAVITROPIC IN THE LIGHT 1
Sequence:
MASSTSGIFFQGDDESQSFINSHLTSSYGNSSNSAPGCGGPTGGYHNLSMVSGDMHNPVMMSVSTPGPSAGASSLVTDANSGLSGGGPHLQRSASINNESYMRLPASPMSFSSNNISISGSSVVDGSTVVQRHDPSVQLGGSSATSLPTSQTNQIPLSMARRASESFFQDPNNLTQARKKPRLDSKQDDALQQQILRQWLQRQDILQQQQQQQQQGQNPQFQILLQQQKLRQQQQYLQSLPPLQRVQLQQQQQVQQQQQLQQQHQQQQQQLQQQGMQMQLTGGPRPYENSVCARRLMQYLYHQRQRPSESSIVYWRKFVTEYFSPRAKKRWCLSHYDNVGHSALGVSPQAATDEWQCDLCGSKSGRGFEATFDVLPRLNEIKFASGVLDELLYLGVPSERRYGSGIMVLEYGKAVQESVYEHIRVVREGHLRIIFSQELKILSWEFCTRRHEELLPRRLVAPQVNQLLQVAEKCQSTIDQSGSDGIHQQDLQANSNMVMAAGRQLAKSLESHSLNDLGFSKRYVRCLQISEVVSSMKDMIDFCRDQKVGPIEALKSYPYRMKAGKPQMQEMEQLAAARGLPPDRNSLNKLMALRNSGINIPMNNMSGQGSLPGSAQAAAFALTNYQSMLMKQNHLNSDLNNTTIQQEPSRNRSASPSYQGTSPLLPGFVHSPSISGVSSHLSPQRQMPSSSYNGSTQQYHQQPPSCSSGNQTLEQQMIHQIWQQMANSNGGSGQQQQSLSGQNMMNCNTNMGRNRTDYVPAAAETPSTSNRFRGIKGLDQSQNLEGIISNTSLNFGNNGVFSNEVDESMGGYSWKS
Protein: Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) (P16277)
Organism: Mus musculus (Mouse)
Function: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptor FCGR2 (By similarity). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (By similarity). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Present and active in lipid rafts (By similarity). Membrane location is required for the phosphorylation of CD79A and CD79B. {ECO:0000250, ECO:0000269|PubMed:7592958}.
Interaction partners:
- B-lymphocyte antigen CD19
- B-cell antigen receptor complex-associated protein alpha chain
- B-cell antigen receptor complex-associated protein beta chain
- Protein FAM167A
- Fc receptor-like A
Sequence:
MGLLSSKRQVSEKGKGWSPVKIRTQDKAPPPLPPLVVFNHLAPPSPNQDPDEEERFVVALFDYAAVNDRDLQVLKGEKLQVLRSTGDWWLARSLVTGREGYVPSNFVAPVETLEVEKWFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDITTQGEVVKHYKIRSLDNGGYYISPRITFPTLQALVQHYSKKGDGLCQKLTLPCVNLAPKNLWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTREPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVLEDFYTATEGQYELQP
Protein: Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41) (Q9D5R3)
Organism: Mus musculus (Mouse)
Function: Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9Y592}. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to centrioles at all stages of the cell cycle, including mitosis. {ECO:0000250|UniProtKB:Q9Y592}.
Interaction partners:
- Sodium channel and clathrin linker 1
- Centrosomal protein of 89 kDa
- Centrosomal protein of 164 kDa
- Fas-binding factor 1
- Ninein
- Outer dense fiber protein 2
- Intraflagellar transport protein 20 homolog
- Rab-3A-interacting protein
- Centromere protein F
- Cilium assembly protein DZIP1
Sequence:
MDTFPSLFPPGGDSRLNPEPEFQNMLIDERVRCEHHKHNYQALKIEHKRLQEEYVKSQNELKRVLIEKQASQEKFQLLLEDLRGELVEKARDIEKMKLQVLTPQKLELVKAQLQQELEAPMRERFRTLDEEVERYRAEYNKLRYEYTFLKSEFEHQKEEFTRVSEEEKMKYKSEVARLEKDKEELHNQLLSVDPTRDSKRMEQLVREKTHLLQKLKSLEAEVAELRAEKENSGAQVENVQRIQVRQLAEMQATLRSLEAEKQSAKLQAERLEKELQSSNEQNTCLISKLHRADREISTLASEVKELKHANKLEITDIKLEAARAKSELERERNKIQSELDGLQSDNEILKSTVEHHKALLVEKDRELIRKVQAAKEEGYQKLMVLQDEKLELENRLSDLEKMKVERDVWRQSEKEQCEEKLRASQMAEEAARRELQSTRLKLQQQIVNTEKAEKEKLENSELKQQISHLQIQVTSLTQSENDLLNSNHMLKDMVERLKQECRNLRSQAEKAQLDVEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQRAATAQKKRKSLHENKLKRLQEKVEVLEAKKEELETENQVLNRQNVPFEEYTRLQKRLKDIQRRHNEFRSLILVPNMPPTASISPANFQSAVTVPGAELSFPPHLQEEQHQRELSLLRKRLEELETTQRKQLEELGSPGE
Protein: Insulin receptor substrate 2 (IRS-2) (Q9Y4H2)
Organism: Homo sapiens (Human)
Function: May mediate the control of various cellular processes by insulin.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P81122}.
Interaction partners:
- Insulin receptor
- Growth factor receptor-bound protein 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Insulin
- Insulin-like growth factor 1 receptor
- Insulin receptor substrate 1
- Suppressor of cytokine signaling 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Insulin-like growth factor 1
- Suppressor of cytokine signaling 3
Sequence:
MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEATAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFYGYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGAALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTFPASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTPPDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLEPQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPSLPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPRPSASPSSSLQPPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTYASIDFLSHHLKEATIVKE
Protein: Isocitrate lyase (ICL) (EC 4.1.3.1) (Isocitrase) (Isocitratase) (P9WKK7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. It could also catalyze the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route) (By similarity).
Interaction partners:
- Malate synthase G
- Acetate kinase
- 3-hydroxybutyryl-CoA dehydrogenase
- Putative isocitrate lyase subunit B
- Putative isocitrate lyase subunit A
- Aconitate hydratase A
- Probable oxidoreductase
- Uncharacterized FAD-linked oxidoreductase Rv2280
- 2-methylcitrate synthase
- HTH-type transcriptional regulator RamB
Sequence:
MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH
Protein: U2 small nuclear ribonucleoprotein A' (U2 snRNP A') (P43333)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA (By similarity).
Subcellular location: Nucleus {ECO:0000305}. Nucleus speckle {ECO:0000269|PubMed:28760995, ECO:0000269|PubMed:36282917}. Note=Colocalizes in nuclear speckles with DRT111/RSN2/SFPS. {ECO:0000269|PubMed:28760995, ECO:0000269|PubMed:36282917}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- At2g32600/T26B15.16
- U1 small nuclear ribonucleoprotein C
- Splicing factor SF3a60 homolog
- Small nuclear ribonucleoprotein SmD3a
- U2 small nuclear ribonucleoprotein B''
- Nuclear protein-like
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein E
- U1 small nuclear ribonucleoprotein A
Sequence:
MVKLTADLIWKSPHFFNAIKERELDLRGNKIPVIENLGATEDQFDTIDLSDNEIVKLENFPYLNRLGTLLINNNRITRINPNLGEFLPKLHSLVLTNNRLVNLVEIDPLASIPKLQYLSLLDNNITKKANYRLYVIHKLKSLRVLDFIKIKAKERAEAASLFSSKEAEEEVKKVSREEVKKVSETAENPETPKVVAPTAEQILAIKAAIINSQTIEEIARLEQALKFGQVPAGLIIPDPATNDSAPMEE
Protein: Transport protein particle (TRAPP) component (Q9CAW4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Trafficking protein particle complex subunit
- SNARE-like superfamily protein
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit
- Trafficking protein particle complex II-specific subunit 130 homolog
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Tetratricopeptide repeat
- Trafficking protein particle complex II-specific subunit 120 homolog
- Trafficking protein particle complex subunit-like protein
Sequence:
MGREVAESCVDTMLMEMVAMYSGRFYANKPELAARRIEAIGYQVGHQLSERYTMERPRFSDHLEAIKFICKDFWSEVFKKQIDNLKTNHRGTFVLQDNKFRWLSRVSIDPSSENETQDPSTPGESKAAQAVSMYLYFPCGIIRGVLSNLGIPCAVSADISSLPTCSFVIRVKA