wanglab/gogpt-training-data huggingface dataset:
Protein: AT20596p (Striatin interacting protein, isoform A) (Striatin interacting protein, isoform C) (Q9VZQ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMLTSINNSFEQDTHDADANCDGPDLDFVYADVDGYQNEIAELYSYTEFSEFQMNVKAFEDQMELYDLPPNWQKQDSASQRGIVMKLVDQLEVSDRSFRMQAARCILYLAQGCWAEVQSDEEQHQITRDNVLVLYQLGVFASFIDLLNMEIESACSPDIVAVKITNVTLVDSTDIRVILSVLYIITETIRDEKEKGSEDYRELADSFVQEINSPLPDGELLAVKLLGMITRFCSGAAPQFPMKKVVLLLWKVSLLGLGGMDVLKNLKNEYRLKVGLEPITEDTLEVTKCMRASSPPATATDILENQYPKRNFKRSLMKQRFLDEPEQIDMEMGGNEGQNNANNGSGNGGNGEEELSQYYRPYDDPSSSASTTSTANPNNQPSLTQPPAAVPPVQITARLPWTPKVRQKDIDQFLDISRNKFIGYSLIGDHESLAGLPQPIHEGFKTLQRHMYMSLADVQIKKEEDIARNPISTHEDEIKLTPAEVLYQAILPNLPQYMIALLKVLLAASPTSKSKTESINIMADVLPRKMPLTATQSTKLTVDIGRHKEIIVKAVSAIILLYLKHFKINHVYQFEFMSQHLVFANCIPLVLKFFNQTITEYVNTKNSIPLLDFPSCVIGEQPDLSGDSFVYGGEMSDKSYSWRNVFSCINLLRILNKLIKWKHSRVMMLVVFKSAPILKKTLKVRHAMMQLYVLKLLKMQTKYLGRQWRKSNMKTMSAIYAKVRHRLNDDWAFGNDLESRPWDFQAEECTLRACVDRFNLRRYPEATQKCGNNGTAAQNAENAQQSNMMAGNNGCGNNGDANGYGNNGGGGNGGHNQQQQLNDYGVEGGFPSDEILTHSDFAFFGHSGWWDRKVELTDYFKANYAVWLEEEVYNSQTDWDAL
Protein: Alpha/beta hydrolase domain-containing protein 17B (Abhydrolase domain-containing protein 17B) (EC 3.1.2.22) (Q5VST6)
Organism: Homo sapiens (Human)
Function: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q7M759}; Lipid-anchor {ECO:0000250|UniProtKB:Q7M759}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7M759}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q7M759}; Lipid-anchor {ECO:0000250|UniProtKB:Q7M759}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7M759}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q7M759}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q7M759}.
Interaction partners:
Sequence:
MNNLSFSELCCLFCCPPCPGKIASKLAFLPPDPTYTLMCDESGSRWTLHLSERADWQYSSREKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGNAVDLGQMSSFYIGLGSRINCNIFSYDYSGYGASSGKPTEKNLYADIEAAWLALRTRYGIRPENVIIYGQSIGTVPSVDLAARYESAAVILHSPLTSGMRVAFPDTKKTYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHNDVELYGQYLERLKQFVSQELVNL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9JJ76)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQQAGNTSPRAISRADRERKVSMRLHRGAPANVSSSDLTGRQEVSRIAASQTSVPFDHLGK
Protein: ABC transporter ATP-binding/permease protein YojI (P33941)
Organism: Escherichia coli (strain K12)
Function: Mediates resistance to the antibacterial peptide microcin J25, when expressed from a multicopy vector. Functions as an efflux pump for microcin J25, with the help of the outer membrane channel TolC.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Alpha-ketoglutarate-dependent dioxygenase AlkB
- Bifunctional transcriptional activator/DNA repair enzyme Ada
- Iron
- Ferric enterobactin transport ATP-binding protein FepC
- Iron
Sequence:
MELLVLVWRQYRWPFISVMALSLASAALGIGLIAFINQRLIETADTSLLVLPEFLGLLLLLMAVTLGSQLALTTLGHHFVYRLRSEFIKRILDTHVERIEQLGSASLLAGLTSDVRNITIAFVRLPELVQGIILTIGSAAYLWMLSGKMLLVTAIWMAITIWGGFVLVARVYKHMATLRETEDKLYTDFQTVLEGRKELTLNRERAEYVFNNLYIPDAQEYRHHIIRADTFHLSAVNWSNIMMLGAIGLVFWMANSLGWADTNVAATYSLTLLFLRTPLLSAVGALPTLLTAQVAFNKLNKFALAPFKAEFPRPQAFPNWQTLELRNVTFAYQDNAFSVGPINLTIKRGELLFLIGGNGSGKSTLAMLLTGLYQPQSGEILLDGKPVSGEQPEDYRKLFSAVFTDVWLFDQLLGPEGKPANPQLVEKWLAQLKMAHKLELSNGRIVNLKLSKGQKKRVALLLALAEERDIILLDEWAADQDPHFRREFYQVLLPLMQEMGKTIFAISHDDHYFIHADRLLEMRNGQLSELTGEERDAASRDAVARTA
Protein: Anti-silencing function 1B histone chaperone (K7ES22)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAKVSVLNVAVLENPSPFHSPFRFEISFECSEALADDLEWKIIYVGSAESEEFDQILDSVLVGPVPAGRHMFVFQLQRNILASNPRVTRFHINWDNNMDRLEAIETQDPSLGCGLPLNCTPIKGLGLPGCIPGLLPENSMDCI
Protein: Retrotransposon hot spot (RHS) protein, putative retrotransposon hot spot protein 5 (RHS5), putative (Q9N942)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNQNGGSVGDTRNVLNGWLNGAYRPMKRQAGRENENPSETGEGKSLEEKLYESIYNAKLSHIIIDDGTQPLGMRLVDGMPNEGLMWKDEEVNVVPEIEETLEQKPERTKGVELLVLTSEMGWPYTGFARGSNSDIFIRREELRVWNVVRNGIELWRTQRVIPGCLYLPRSYVAIGNPGIGKSQNLGSFILYKLLHYDAEELPVVAYFRGVAAYIFEKSSGGGVGRVKKYSKGAAMDLLEVISSNTRGYIIYDFVNKGEQPPADVAPKWGSILISSPNLRNFDSWQKQRKGAFIVVNCWAMSEMRAFFSRIGPKLFPQATPVELREKWNMYKDRVERVGPSLRYVFDEVMYEQQLTAVDGELGSIVAGNKYGIYTKVLDNCGEWRESDASHKLVKIVRIKAREGNFFDTYVCVAHSESIKKRILNVVFSGIAEEWALVSGMTRDASVIGHYFEKNAIKYLCSPKVLTCFVSLITKLPANERARRMRTRKSILQHVRDGLLKVGRTNTVPGDINWAESEGAPVELYVPCVSNFPVADAFFIFDDKEAAQASGTTGKKTIVLLQFTVASSHHTTTDEFIHLLQSLFPSAEGGGHQNEATVEQLKEITEMFHWEIIYVQHFESTAMRSEQKCEITQGKAKHRSHQFVEGFWKNNVQQYHVQYEDNIVTKMLAVAAVGRR
Protein: Colony-stimulating factor 3 receptor (granulocyte) (Granulocyte colony-stimulating factor receptor isoform X1) (F1R904)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Colony-stimulating factor 3
- Tyrosine-protein kinase JAK1
- SI:bY184L24.2.1
- Epstein-Barr virus-induced 3.
- Suppressor of cytokine signaling 3
- Interferon regulatory factor 8
- Colony-stimulating factor 3
- Macrophage colony-stimulating factor 1 receptor
- Suppressor of cytokine signaling 3
- Plastin-2
Sequence:
MASVSLVLLLWMYIYVVIKVTGASSCGNVYTPAPVVLAGSPVSVSCSIEEDCPLTKGKVFYVQWRIDGQVVPRNYTNQESNMTYSVLIPRLQDTSASILCLVCVQEDCQIVDGVEVKNGNPPVPHNLSCALTLVKMPSLRCDWNPVQEIANLPTNYTLHLFRAKSQKVYAVPPGQHFYVVPRDAYGYFTELEISVTAANVFGNTTTDPLKLTPLNTVKFDPPSITRIEAHRYGCLKYSWSLSETQKWLQLTFIVQLRLKTVNNQPNKDLVYTSRQLQLNPIEVCSLLHWTDYRSTVRVKYYATSEWSEWSDPKTATTLNKAPAGRLDTWLKVNNQTAQLYWKPSQQFRANGQNLSYSVDSKDTKKRLCVTTETYCFFSLTKWDKKISLRARNEVGFSDHNEVPVAVHRNKGLEPVSNFSVHPQSNTSLHVIWKSPAFSNVTSYVLEWRSLCGTTAAPLSFTLIHKNKSNTTLTGLEPSKPYEISIYPRYVKGIGRPVTVLAYSSEKAPSDAPELNYEEISRSHLKFHWGQIPLEKRNGIIQGYRFYFWHNKNEIKEIMTTETSVEVKDLQPHTKYHALLSICTKGGCVNGSFSTLTTERLDGIEMVIFVIPACIGASLLVIIIVFTCFGKQERVKMCLWPIIPDPANSSIKRWTTTDSLQGLPAFKEDKDPVLVYLSHLSLLDMTEKEPFKSGYVKENQWPDDLNIHADTQSCDLELERESVPYATVLFSTPYQINSSNPPAYVRSESTQPLLAGDEPGSPPPPYENVPRGGAVSALNRFSAFSQSTQSEESDELWEEFPMLRSLEVNHI
Protein: Uncharacterized protein (Q38B40)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEDDADAYLRRVSQLKRKHFRKDSVTAYHPTPVEVETADTRPIHTVARRLPMKKRKRMCDDDEFDVISLVRDAVNVSSGGVFVADIPSTGPLVGCSGDRKVLQQPVKITLMEKWFPGRTLQNATLDPAQAPLYQYTEVSTKRMKDARERFVSLKAGVEDALKYSFVGECTNFDEVVSRMTKESWIELRNTLFQISSRASLRRKKGAVRAMKYILSTNVGEHVPKSSILRHWNEYLLIHGPEQGFQPTLSLFVWVESAGITALFTAVVSRALKLFKQGKKPMAYSFYDAQEESEPSCCDEAATSEEDECVDSGEVLSCEGSVEKSAKESEPIAVGTGEGNDNNLVRPPSLVERLPRLGGCSEDVISLLSFLRVLMPVDYLDEDGRMIGRSAGYGVWLYACLTAVDTPFDPDLDRLVHEFFRTCCLQLRVLGEAHNVRGDDRGAILKVFPSRKDDPPQSSQYNSLGDVRKEDVLALHTIIVVLAKLFRLNGNRLVPL
Protein: DNA replication licensing factor MCM4 (EC 3.6.4.12) (A0A3B3IU45)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL
Protein: Serpentine receptor class delta-28 (Protein srd-28) (O17956)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLYQLLHTVLSVVGVSLNAFMMYLALTKSPKIMLPCSAIITIKTFTDILTSAMSFFVMQRIVTDGSSILVIPTGPCTHLGPTACYIGHMFMLCFLECNLIWMISSYIFRYYILYVRDPSIKSLVFVAICLSIPSFIHMATWISNYDPTVAIAIPENVGIESRDMVLGGTIVTWSALTLIIQLFITSILVLIAYAWIRNTLLSFAVKMGSDKNDVKKLNTRLVKVINFQVFLPSFIFLGVFVFVGMFTQLIDPKISQYLVSVIFMFSPICSPFSYILFVPHYLNVILGNKKVSEAKSTTEGCTFRHVNMAASTSNTPECSA
Protein: C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) (Q5HZI2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MRKTNMWFLERLRGSGENGASRGEAGDKSSKGPLYSNVLTPDKIPDFFIPPKLPSGPTEAEGQADLGPSTSEQNLASPGPRRAPRSPRLPAKLASESRSLLKAATRHVIQIESAEDWTAEEATNADPQAQGAMSLPSVPKAQTSYGFATLAESPHTRRKESLFHSEHGALAQVGSPGAGRRRAGAKGNGGDGGSREVGGALMSPSRYFSGGESDTGSSAESSPFGSPLLSRSVSLLKGFAQDSQAKVSQLKQSVGRHGSLSADDSTPDTSPGVRRRLSRRATPEPGPESGQAPRGEHTVKMGTRGSVRLLAEYEAAQARLRVRLLAAEGLYDRPCDARSINCCVGLCLVPGKLQKQRSTIIKNSRHPIFNEDFFFDGLGPASVRKLALRIKVVNKGSSLKRDTLLGEEELPLTSLLPFL
Protein: 28S ribosomal S34 protein (Q9FHC3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein
- DNA-binding protein RHL1
- Protein TORNADO 1
- 50S ribosomal protein L27
- Small ribosomal subunit protein mS38
- Small ribosomal subunit protein uS11m
- Large ribosomal subunit protein mL53
- Large ribosomal subunit protein uL10c
- Small ribosomal subunit protein uS2m
- Putative ribosomal protein L6
Sequence:
MAMTLINRAISRTETVGAFRLSLNLLRNFSAAPASENPSSDSSKPKRRKKKNLIEVAQFLPNWGIGYHMAKAHWNGISYEITKINLYKDGRHGKAWGIVHKDGLRAAEAPKKISGVHKRCWKYIPNLSKTAPATTSAHVQAA
Protein: TNF superfamily member 13b-like protein (Tumor necrosis factor ligand superfamily member 13B) (Zgc:172115) (A8WG11)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MPAEDVGPGRGERRRLSWLFLVLVAAAITSSSLSVISLYHVLALKAEVEGLRAEVARKREEQSGMLDEPVNEAEKQTHREEGGDSIEYLHQADMDITTDPSVMSKRSLSHAPNKAEPQPCLQMMADNKKKTFQKEFAFDYCTAIPWQVGLKRGSALEEEQGTILVKEEGFFFIYSQLSFSQVYYTDPTFAMGHIVIRIKKNVVGNESQHVVLFRCIQSMNRVNHYNTCYTGGVVKLDSGDKLDLLIPRANANISLEGDATFLGAIKLA
Protein: Small ribosomal subunit protein bS16 (C3SYP2)
Organism: Escherichia coli
Interaction partners:
- 50S ribosomal protein L11
- Small ribosomal subunit protein uS11
- Alternative ribosome-rescue factor A
- GTP pyrophosphokinase
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS10
- Elongation factor Tu
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS7
Sequence:
MVTIRLARHGAKKRPFYQVVVADSRNARNGRFIERVGFFNPIASEKEEGTRLDLDRIAHWVGQGATISDRVAALIKEVNKAA
Protein: Fibrillin 2b (Fibrillin-2b isoform X1) (A0A0G2KQ62)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- Pku300.
- Furin
Sequence:
MGVWKLANVVLWWAAVHSVQGQGDGDIQASRFTGKPEGEVQQRVRRRGQESLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGHLAPSCGAAAVQSCSVRCMNGGMCNEDACSCQKGYTGTHCGQPVCESGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLSGIVCTKTLCCATIGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAVPGLCAGGNCINTVGSYECKCPAGHRQSETNQKCEDIDECATISGVCDGGECTNTAGSYVCTCPRGYITSTDGSRCVDHRIGTCFSSLANGRCASELSGQYTKMQCCCDTGRCWALGHIPEMCPVRGSDEYRRLCIQRLPFGTGNGGIIHDGNGGLNIGGYGKGPSQNGNGGGGYIYGSEHTFTNGNGNGGQKIQISQLNETTIDVCKHFTNLCLNGRCIPTPTSYRCECNMGYRQDVRGECIDVDECVSNPCVNGDCVNTQGSYHCKCHEGYQGTPTKQACIDIDECIVNGVMCRNGRCVNTDGSFQCICNAGFEISPDGKNCIDHDECATTNMCLNGMCINEDGSFKCICKPGFALAPNGRYCTDIDECHTSGICMNGRCVNTEGSFRCECPPGLAIDVDGRVCVDTHMRTTCYGAIKMGVCSRPFPGAVTKSECCCANPEHGFGEPCQPCPAFNSAEFQAVCSSGPGITTDGRDINECALDPDICQNGICENLRGSYRCICNIGYESDASGKNCVDINECLVNRLLCDNGMCRNTPGSYTCSCPKGFSFKADSETCEDINECDSNPCINGICRNIAGSFNCECSHGSKLDSTNTVCVDSMKGTCWLNIQDGRCEVNINGATLKSECCSTLGAAWGSPCERCEIDPACSKGFGRMKGLVCEDINECEVFPGVCTNGRCVNTQGSFRCECPEGLTLDGAGRTCVDVRSEQCYMKWDEDECVEPLPGRYRVDMCCCTVGAAWGVDCEACPKPNTNEFKTICPRGPGIANRGDILTGRPFYKDVNECKVFRGLCTHGTCRNTIGSFKCRCDSGFALTMEERNCTDIDECTISPDLCGHGVCVNTPGSFECECFDGYESGFMMMKNCMDIDECERDPLLCRGGTCLNTEGSYECDCPPGHQLSTEASACEDVNECQLSDNLCKHGQCVNMVGTYQCSCETGYQVTPDRQGCVDIDECTIMNGGCDTHCTNSEGSYECSCSEGYALMPDLRTCADIDECEDTPDICDGGQCTNIPGEYRCLCYDGFMASMDMRTCIDVNECDLNPNICLHGDCENTKGSFICHCQLGYFVKKGSTGCTDVDECEIGAHNCDLHAACVNAPGSFKCRCRDGWEGDGIKCIDVDECVTEEHNCNPNAECLNTPGSYRCSCKEGFNGDGFSCSDMDECADNVNLCENGQCLNAPGGYRCECEMGFTPTEDSKACQDIDECNFQNICVFGSCQNLPGMFRCVCDYGYELDRSGGNCTDINECFDPVNCINGVCVNLPGSYLCNCPPDFELNPSGVGCVDTRVGNCFLDTLDRGDGGISCSAEIGVGVTRASCCCSLGGAWGNPCELCPSVNSTEYKTLCPGGEGFRPNPITVILEDIDECQELPGLCQGGNCVNTFGSFQCECPAGYYLNEETRICEDIDECTAHIGICGPGTCYNTLGNYTCVCPPEYMQVNGGNNCMDMRKSVCYRNFNDTCENELSFNMTKKMCCCAYNVGKAWNRPCEACPTPATSEYQLLCGNQAPGFIIDIHTGKPIDIDECREIPGICANGVCINQIGSFRCECPMGFSYNNILLICEDIDECNSGDNLCQRNANCINIPGSYRCECSAGFKLSPSGACIDRNECQEIPNVCSHGECIDTQGSFRCLCHNGFKTTPDQTMCMDIDECDRQPCGNGTCKNTVGSYNCLCFPGFELTHNNDCMDIDECSVHASQVCRNGQCINNMGSFKCLCLDGYNLTPDGKNCVDINECVTLPGACQPGTCQNLDGSFRCICPPGYEVQNDKCVDINECNVEPNICQFGTCKNTPGSFQCICQPGFVLSDNGRRCFDTRESFCFTRFEAGKCSVPKPRNTTKAKCCCSLLPGEGWGDPCELCPRDTEEAAFHTLCPYGHEAVPKPEGREDMNECVENPEICGNGLCINTDGSFRCECPFGYNLDYTGVNCVDTDECSIGNPCGNGTCSNVPGGFECSCQEGFEPGPMMTCEDINECAVNPLLCAFRCVNTFGSYECMCPTGYVLRDDNRMCRDQDECAEGLDDCASRGMACKNQIGTFMCICPPGMTRRPDGEGCMDLNECRSKPGICKNGRCVNTVGSYRCECNEGFEASATGTECIDNRKGFCFTEVLQTMCQQSSTNRNTVTKSECCCNGGRGWGSLCELCPLPGTIQYKKMCPLGPGYTTDGRDINECEVMPNLCKNGQCINSVGSFRCHCNVGYTNDFTGTSCIDMDECSQSPKPCNFLCKNTEGSYLCSCPRGYILQPDGKTCKDLDECSTKQHNCQFLCVNTIGGFTCKCPSGFTQHQTACIDNNECSNQPNICGSRASCLNSPGSFNCECQKGFSLDATGLNCDDVDECGGNHRCQHGCQNMMGGYRCGCPQGYVQHYQWNQCVDENECTGNQVCGSASCYNTLGSYKCVCPSGFDFEATAGGCQDVNECSMGNNPCSYGCSNTDGGYLCGCPGGFYRAGQGHCINGVGFQGQFGSEGGDDEESLSPEACYECKINGDLGKKGRHRRNADDNELKETVSMASMDIQTSIPMNLSLAKLLNKEPLLELLPALEPLEHHVRYVITHGNQGEHFRILERRDGKSVLRLGRRPPAPGLYRLEIASLRLFGPRKLQQMEDQHDSDYLLGEIGDALRIKLHIHLH
Protein: Aldose 1-epimerase (EC 5.1.3.3) (A0A0H2UMV2)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVAPDKAGNFANVILGFDDFDSYVGNSPKHGASVGPVAGRIAGATFELNGKTYDLEVNNASNCNHSGSTGWDSSLFEVEEVSDHGLTLYTERTDGTGGFPGNLKIWISYHLEETGAYEISYKVTTDQDTLVNPTNHSYFNLSGDFTQTIDRHVFQLNTEGIYSIAPDGVPAKTPEANRDVVKHVYNGTLLKDIFAEEDEQIQLASGLDHPFALPAGHDNAGFLYDQNSGRFLLFKTEAPCFVVYTANFVDESVIIGGQPMLQHNGIALEAQALPDAIHSDLKGQVILKAGQTFTSKTRYELVVK
Protein: SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP) (O60880)
Organism: Homo sapiens (Human)
Function: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:9774102}.
Interaction partners:
- Signaling lymphocytic activation molecule
- Tyrosine-protein kinase Fyn
- Natural killer cell receptor 2B4
- SLAM family member 6
- SLAM family member 5
- T-lymphocyte surface antigen Ly-9
- CD48 antigen
- T-cell surface glycoprotein CD3 delta chain
- Tyrosine-protein kinase Lck
- T-cell surface antigen CD2
Sequence:
MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP
Protein: Rab GTPase-activating protein tbc-11 (RabGAP tbc-11) (TBC1 domain family member 11) (H2KZZ6)
Organism: Caenorhabditis elegans
Function: Rab GTPase activating protein for the small GTPases rab-6.1 and rab-6.2 (Probable). Probably acts through rab-6.1 and rab-6.2 to play a role in microRNA-mediated gene silencing in different tissue types. Required for seam cell division and alae formation.
Interaction partners:
- Ras-related protein rab-6.1
- Ras-related protein rab-6.2
- TBC1 domain family member 13
- Rab GTPase-activating protein tbc-8
Sequence:
MEDFKDFTEVTQFTNVQYLGCSQLVNNDNDNEMKALMKVLDEQKGAQTINVTLVVPHNISGTVKLIDAQGKVLSSFSLVNIRFCIRGESSTSQNNCFGISFTHKISVGEHNSSDILHQCHVFRTSKAETAAKALYSFSYAFSNKNVSSESNRLEFQFESILEVKENDGTVEKPSWKLCPQHNGVFKVRRDREKKIVVQLRQIDGFLLNIKKCFGMLLAAGRNLRHSDLQLLEMDRNATGTDSAVFVIEANWDPRVHMFEVLNTETPRDTRVFMTVAIDVIVSEISEPIRFSMEAMSRVFHEHERFYKTPQTVVSEEFTLVLEKSCDQSDPNDRKLTFISLESDSDRKRSKQNLGKSPSRMPTQLLHPTGDDESDCDEPLLSGSGKVSQECKEEHLEMWDQLIENWDQQSDRPQKISELVLDGIPDKLRGRVWQLLSNVRILAIDQPDLVEKYHIFLSQPCPSEQVIMRDIHRTFPAHDYFKESQGKGQQSLYKISKVYSLYDEEVSYCQGLSFLAASLLLHMPEEQAFCTLVKIMFNYGLRDLFKLGFDNLHLRFFQLTALLKDYIPDLSHHLEHIGIETHMYASQWFLTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALLDDAKTDLLQLDFEGTLKYFRVSLPRKYRTEASTKCLIHKAVKFRLNHSKLEVYENEYKRIKELERENEDPVLRMEKEIGRHQANTLRLERENDDLAHELVTSKIELRRKLDVAEDQIETSANAIERLTRQNMDILEENKNLMREYEQIKEMYRRDVLRLEENGSRAEKLLAEYKKLFSERSKRAENEREHFEVQKKAIIARISDCDKCWPAVCEWEKNRSPVHSASTPTGPDLLTKLEEREDHIKNLEIDLAQTKLSLVEAECRNQDLTHQLMAQSESDGKKWFKKTITQLKEVGSSLKHHERSNSSVTP
Protein: Antitoxin MazE7 (P9WJ85)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7.
Interaction partners:
- Probable endoribonuclease MazF7
- Endoribonuclease MazF9
- Probable endoribonuclease MazF1
- Putative antitoxin VapB18
- Precorrin-3B synthase CobG
- Cobalamin biosynthesis protein CobIJ
- Precorrin-8X methylmutase
- Antitoxin MazE5
- Endoribonuclease MazF6
Sequence:
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG
Protein: Gasdermin-E (Inversely correlated with estrogen receptor expression 1) (ICERE-1) (Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)] (O60443)
Organism: Homo sapiens (Human)
Function: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis.
Subcellular location: [Gasdermin-E, N-terminal]: Cell membrane {ECO:0000269|PubMed:28045099, ECO:0000269|PubMed:28459430}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.; SUBCELLULAR LOCATION: [Gasdermin-E]: Cytoplasm, cytosol {ECO:0000269|PubMed:28045099}.
Interaction partners:
- Gasdermin-A
- Caspase-3
- Gasdermin-C
- Gasdermin-B
- Cellular tumor antigen p53
- Granzyme B
- Cytochrome c
- High mobility group protein B1
- Tumor protein 63
- Caspase-1
Sequence:
MFAKATRNFLREVDADGDLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQFLSLTLGDVLIEDQFPSPVVVESDFVKYEGKFANHVSGTLETALGKVKLNLGGSSRVESQSSFGTLRKQEVDLQQLIRDSAERTINLRNPVLQQVLEGRNEVLCVLTQKITTMQKCVISEHMQVEEKCGGIVGIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELYVKLDGQFEFCLLRGKQGGFENKKRIDSVYLDPLVFREFAFIDMPDAAHGISSQDGPLSVLKQATLLLERNFHPFAELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGLSPTVAVLGELKPRQQQDLVAFLQLVGCSLQGGCPGPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLLRALSDDGVSDLEDPTLTPLKDTERFGIVQRLFASADISLERLKSSVKAVILKDSKVFPLLLCITLNGLCALGREHS
Protein: Syntaxin 6 N-terminal domain-containing protein (Q57WS4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Vesicle transport v-SNARE N-terminal domain-containing protein
- Syntaxin 5
- Vesicle-associated membrane protein, putative
- Vacuolar protein sorting-associated protein 51 homolog
- Vacuolar protein sorting-associated protein 45, putative
- Vacuolar protein sorting complex subunit, putative
- Pep3/Vps18/deep orange beta-propeller domain-containing protein
- RING-type domain-containing protein
- Vps53 N-terminal domain-containing protein
- Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein
Sequence:
MMESMNLEQPPRLNADPWRDMEPKVDAMLGDLLMISERFRRIVNPTVSDADELIEAINSVGGEVETMRVALDTTIERPELFSVDAEELKRRTEKTRSWERDVAKAIELRSKILSNREGQIQDPLESNVMTPNTWVDLDTTHIHPSAQSSHMPMNSCEATTDTSVGVVESQALMPVGIPIREQTVKASEYSTASVEVHTVDDVDDPNNEGSLLKYVLVILLVSSILVAISLIFF
Protein: Aerobic respiration control sensor protein ArcB (EC 2.7.13.3) (P0AEC3)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
- Aerobic respiration control protein ArcA
- Signal transduction histidine-protein kinase BarA
- Sensor protein EvgS
- Chemotaxis protein CheY
- Sensor protein TorS
- Chemotaxis protein methyltransferase
- Sensor histidine kinase RcsC
- Probable diguanylate cyclase DgcE
- Phosphotransferase RcsD
- Oxygen sensor protein DosP
Sequence:
MKQIRLLAQYYVDLMMKLGLVRFSMLLALALVVLAIVVQMAVTMVLHGQVESIDVIRSIFFGLLITPWAVYFLSVVVEQLEESRQRLSRLVQKLEEMRERDLSLNVQLKDNIAQLNQEIAVREKAEAELQETFGQLKIEIKEREETQIQLEQQSSFLRSFLDASPDLVFYRNEDKEFSGCNRAMELLTGKSEKQLVHLKPADVYSPEAAAKVIETDEKVFRHNVSLTYEQWLDYPDGRKACFEIRKVPYYDRVGKRHGLMGFGRDITERKRYQDALERASRDKTTFISTISHELRTPLNGIVGLSRILLDTELTAEQEKYLKTIHVSAVTLGNIFNDIIDMDKMERRKVQLDNQPVDFTSFLADLENLSALQAQQKGLRFNLEPTLPLPHQVITDGTRLRQILWNLISNAVKFTQQGQVTVRVRYDEGDMLHFEVEDSGIGIPQDELDKIFAMYYQVKDSHGGKPATGTGIGLAVSRRLAKNMGGDITVTSEQGKGSTFTLTIHAPSVAEEVDDAFDEDDMPLPALNVLLVEDIELNVIVARSVLEKLGNSVDVAMTGKAALEMFKPGEYDLVLLDIQLPDMTGLDISRELTKRYPREDLPPLVALTANVLKDKQEYLNAGMDDVLSKPLSVPALTAMIKKFWDTQDDEESTVTTEENSKSEALLDIPMLEQYLELVGPKLITDGLAVFEKMMPGYVSVLESNLTAQDKKGIVEEGHKIKGAAGSVGLRHLQQLGQQIQSPDLPAWEDNVGEWIEEMKEEWRHDVEVLKAWVAKATKK
Protein: RH23394p (Q8MQM7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034100}.
Interaction partners:
Sequence:
MFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRVCN