wanglab/gogpt-training-data huggingface dataset:
Protein: Protein ECT2 (Q9U364)
Organism: Caenorhabditis elegans
Interaction partners:
- Rac GTPase-activating protein 1
- Ras-like GTP-binding protein rhoA
- Kinesin-like protein
- Anillin-like protein 1
- Myosin-11
- WAPL domain-containing protein
- Rho-GAP domain-containing protein
- Kinesin-like protein
- Maternal embryonic leucine zipper kinase
- Calponin-homology
Sequence:
MDVSMLQSPQKRIKTIQKLAVSKKDVHDFKDIFEMLEEQKEKRNINIIQYDSLDDLSGDWSEYTFFCGNFDSDLFRTLTKHQETQALFIIGASVLKNKLLKNEDLMTLRAARPLYCELMKDVTMKLAAEVPNKRELVDLVHYMGGSVRKDTVSRTNVFIAAKVEAKVQSISLVGVPTMRADWVTECWKHRDDSYFDVMEPCFVDKHRLGVFEGLSLFFHGFKQTEIDDMLRSLENTGGKLAPSPTLATHVVYNPDNDEVETLAVSSNQVHVTKEWFWVSLHRGCCAIEDNFALPTGKLHRKPLESSSVSSPIGKSLRSQNSRSLSSMRDCSVEGPTSLNMTPDYIYSNDDVENSCKSPRQPSKRLRVCMEMVETEKNYLSLLKLVVKFKEALECEISHNEFMSRSDVAMMFGKLDPILELHERIFARLTVMSNEANTLLTVVNGKKNDDKNLDFAQVWIDAKEEMKKAYPQYINSYDTIKRLFDKQDRENSKFHTFCKAKESNPEFHRLKLTDLMVKPVQRLPSVILLLKEMAKKSDSKLKNNAEEAAKAIDEVLKTANKTREKNDNFISHLSKFTDIENVPPILVAANRMFIRELVVSPIASTSPGLQQFAKMKLFLFHDVLIITKIRSEKNTMQRLARHASFASLHSRQRRPYRYIDQIQLNTMRSAFRIRAPDEIAKCLELQQQNGSTKPNVFVWCLIHRDEQGGDIDTVFESNDDEEVRDFLDDIHVKILSDCGRFFYSSDPSDMNEINDAMVSDMTTRYFRNLCGAKPQYGHGSQMNITVSERSTQNEWSHNESFMPPPQSQSRMRRAFSNAQLTLATTLGFGRNQSRNNLGQINENTTFLQSPRVSCDPAALANMTSVGGLPGCQSESESTPKRGIRSRLTSTTFLGGRHNILGRNTSMRRQATGFAHSEKELPRSKTSSYRVTDI
Protein: Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2) (Q14627)
Organism: Homo sapiens (Human)
Function: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
Subcellular location: Cell membrane {ECO:0000269|PubMed:18694590}; Single-pass type I membrane protein.
Interaction partners:
- Interleukin-4 receptor subunit alpha
- Interleukin-13
- Interleukin-4
- Chitinase-3-like protein 1
- Interleukin-13 receptor subunit alpha-1
- Tyrosine-protein kinase JAK1
- Interleukin-5
- Insulin-like growth factor-binding protein 3 receptor
- Interferon gamma
- Interleukin-19
Sequence:
MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLDHFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQSSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDHALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNETRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTGLLLRKPNTYPKMIPEFFCDT
Protein: Patatin like phospholipase domain containing 6 (A0A384DVU0)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004643}; Single-pass type III membrane protein {ECO:0000256|ARBA:ARBA00004643}.
Interaction partners:
Sequence:
MGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGAQPVPFVPQVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGLQGGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPGSGLGVPPHSELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIVGLGDQEPTLGQLEQMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEMEEEKSILRQRRCLPQEPPGSATDA
Protein: GRB2-associated-binding protein 1 (F6NTT0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSGGDVVYSGWLRKSPPEKKLRRYAWKKRWFVLRSGRLSGDPDVLEYYKNDHAKKPIRVIDLNLCEQVDAGLSFNKKDLEHSFIFDIKTIDRIFYLVAETEEDMNKWVRNICEICGFNPTDTEDSAKVSHHVNVPGGLVVDMAPSGGLGGALGASALANLPPPYQPVSIRQLGSSSSLDEPQDYLWLLNCESKKPEPNRAHGDCSKSTSSEPDCNDNLPSHYTPTSSTSKNAPVNGFFSTQHPTGLYDSPPLRGQSLSADSQGLYHLPRSYSQDTVLLPKSATSPPIPDGEPGELYVFNTPGRKPSLEAHLRNLSVSYDIPPTPGSNSTYQVPRTAGVEAVSGSTEVIPPPRPPKPSVSGGSVPPERSPTDTYVVPRSVSETDTNYCVPTSAGGNKALRSNTIGTVDSSRLRKDYGSQDCYDIPRPFPSEKSCSFDFNESFNNYFKNKGMVPVGGVSTEEMDENYVPMSVHSLSHQRSGSLSEPIQEPNYVPMTPGTVEFSSLGKQVPPPAHMGFRSSPKTPPRRPIPISECQPPPIDRNLKPDRKVKPAPLEIKPVSEWEEYTAPVRSPVTRSFTRDPSRFTVAPRPSSGQSTASSSDSDECDENYVTMQANMSSDEPNKLGAPMNADGGGSPMVKPKGDKQVEYLDLDLDPGKSTPPRKKKNNGTGISASDERVDYVLVDQQRTQALKSTREAWSDGRQSTEDTPTKGAK
Protein: Serine/threonine-protein kinase 3 (EC 2.7.11.1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] (Q7ZUQ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q13188}. Nucleus {ECO:0000250|UniProtKB:Q13188}. Note=The caspase-cleaved form cycles between nucleus and cytoplasm. {ECO:0000250|UniProtKB:Q13188}.
Interaction partners:
- Protein salvador homolog 1
- WW domain-containing transcription regulator 1
- MOB kinase activator 1A.
- non-specific serine/threonine protein kinase
- Caspase 3, apoptosis-related cysteine peptidase a
- Caspase 3, apoptosis-related cysteine peptidase b
- Transcriptional coactivator YAP1
- TRAF2 and NCK-interacting kinase b.
- Ras association domain-containing protein 5 isoform X1
- Chromosome 2 open reading frame 6.
Sequence:
MEHSVPKNKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATVLKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEHWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIVGAKPVSILRDLITEAMDMKAKRQQEQQRELEEDDENSEEEVEVDSHTMVKSGSESAGTMRATGTMSDGAQTMIEHGSTMLESNLGTMVINSDDEEEEEDLGSMRRNPTSQQIQRPSFMDYFDKQDSNKAQEGFNHNQQDPCLISKTAFPDNWKVPQDGDFDFLKNLDFEELQMRLTALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF
Protein: Nitrilase bll6402 (EC 3.5.5.1) (Mandelonitrile hydrolase) (Q89GE3)
Organism: Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
Function: Nitrilase that mediates the hydrolysis of aromatic alpha-hydroxy nitriles to carboxylic acids. Has high activity toward mandelonitrile and mediates its hydrolysis to mandelic acid. Also mediates hydrolysis of mandelonitrile derivatives. Has weak activity toward aliphatic nitriles.
Interaction partners:
- Indoleacetamide hydrolase
- Indoleacetamide hydrolase
- Amidase
- Blr2084 protein
- Nitrilase blr3397
- Betaine aldehyde dehydrogenase
- Vanillin: NAD oxidoreductase
- Bll7607 protein
- aldehyde dehydrogenase
- Aldehyde dehydrogenase
Sequence:
MQDTKFKVAVVQAAPVFMDAPASVAKAIGFIAEAGAAGAKLLAFPEVWIPGYPWWLWLGTPAWGMQFVPRYHANSLRADGPDILALCAAAAEAKINVVMGFSEIDGGTLYLSQVFISDAGEIIFKRRKLKPTHVERTLYGEGDGSDFRVVESSVGRLGALCCAEHIQPLSKYAMYSMNEQVHVASWPSFTLYRDKAYALGHEVNLAASQIYALEGGCFVLHASAITGQDMFDMLCDTPEKADLLNAEGAKPGGGYSMIFGPDGQPMCEHLPQDKEGILYADVDLSMIAIAKAAYDPTGHYARGDVVRLMVNRSPRRTSVSFSEDENAAVTFTET
Protein: Transmembrane protein (F4JS93)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MLSSMVVPVNGFSLNLSKPNLVVFNGSRVFYGSFSLTCYRIKVRSSQIGIVGDNDSEKSRDSKDEDENERVSGKGVPFIVKLGLGLGLAMIITVISVALKGSGGGGSPFEEVKSLAKVSSSSEGFTFNAFGNRFMIPGNAPGWVYFWLLMAAGCGLFISEEALNIWVGITLARMLTLDGTWQSFAESFSRNAPYIVSTVSWVYWGVCLSDMIPFYIGKLFRQSGASDDVCSKLGIGKEKALSITQAVQKYGNLSGFVERFSVGMRNPTAFFAGALGISPECFFAGVCCGGLITLPLQLVIGFLLRERPMFALAAVATAVGIWTIFPYVVAASTALFLYIRSRYSTKD
Protein: Class E basic helix-loop-helix protein 41 (bHLHe41) (Class B basic helix-loop-helix protein 3) (bHLHb3) (Enhancer-of-split and hairy-related protein 1) (SHARP-1) (O35779)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity (By similarity). Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 and CYP3A11 (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Period circadian protein homolog 2
- Cryptochrome-1
- Basic helix-loop-helix ARNT-like protein 1
- Circadian locomoter output cycles protein kaput
- Period circadian protein homolog 3
- Cryptochrome-2
- Nuclear receptor subfamily 1 group D member 1
- non-specific serine/threonine protein kinase
- Glycogen synthase kinase-3 beta
- Neuronal PAS domain protein 2
Sequence:
MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCAQLVSHLHAVATQLLTPQVTPGRGPGRAPCSAGAAAASGSERVARCVPVIQRTQPGTEPEHDTDTDSGYGGEAEQGRAAVKQEPPGDPSAAPKRLKLEARGALLGPEPALLGSLVALGGGAPFAQPAAAPFCLPFYLLSPSAAAYVQPWLDKSGLDKYLYPAAAAPFPLLYPGIPAAAAAAAAAAFPCLSSVLSPPPEKAGSAAGAPFLAHEVAPPGSLRPQHAHSRTHLPHAVNPESSQEDATQPAKDAP
Protein: F-box protein At2g38590 (Q9ZVI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTTMISNLPRVLIEEIFFRVPLKSLRAVRLTCKSWNTLSKSRSFRKLYISKRATREEESMMIAMMNFDLYSMRVVVDDDVDPSKAFKKKRNKKSIAFKRQPIFLDEQVKISQVFHCEGLLLCFLKEDDTRVVVWNPYCGQTRWIQLRYSHRPHKDRFIYALGYKDKESRGSFQLLRFVDYFLGAPKNQYFWYEIYDFNSDSWTTLDVTPHWCIYCCDRGVSLNGNTYWCAKERKAEDDIVDHIISFDFTNERFGPLLPLPSKVMEHEYEIVTLSYVKEEKLAALFQHYEADWNEFDIWITTKIDAEVVSWSMFLRMDTGPRIEVPHICEGFFIDEEKKVAMGFEEDFDRKTFIIIGEAGYVRKLDIKAHVDRKCRPTVCSYVPSLVQIKKPARGKRKRQSSLEKRLFDQNMLRLEAFKKLGGYF
Protein: Integral membrane protein 2 (A0A384MDP7)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}. Endosome membrane {ECO:0000256|ARBA:ARBA00004639}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004639}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}. Membrane {ECO:0000256|RuleBase:RU367061}; Single-pass type II membrane protein {ECO:0000256|RuleBase:RU367061}.
Interaction partners:
Sequence:
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS
Protein: Phospholipid/glycerol acyltransferase domain-containing protein (Q554U0)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Membrane bound O-acyl transferase family protein
- Probable glycerol-3-phosphate dehydrogenase, mitochondrial
- Phospholipid/glycerol acyltransferase domain-containing protein
- Probable glycerol kinase
- Phospholipid/glycerol acyltransferase domain-containing protein
Sequence:
MGKESSDNSSLSSSSTTTSQSSSSSSSSSSSKSSLSSSSSSTNTSKNSGKGSSLEINQDPWSLLLPTNTSEIDEISKLIEEKLLKQLNKQVNPSKKFNLYDVAPFITDGAEVLLDDEFSKCFNSPEIHAWNWNIYLYPGWLFGCFIRYCILFPLRLTCLIVGCFLFAIAFFLSTTFVKNEKRKKNYQRKCIHFLAMVFIMSWSGVIRYHGVKPLRKKNQIFVANHTTVMDVVVLQSQFCHASVGQKHKGLIGFIQDYILNCIGCLWFDRAESKDRLLVAQQISKHIENENNDPLLIFPEGVCVNNQYCVMFKKGAFELPNVIIYPVAIKYNTLFVDAFWNSKKQSFIRHMFNLMTSWAFVCDVWYLEPQTIREGETATQFANRVKAMIAKKAGIINVPWDGYLKYFKPGSRFAEHKQKIFASRFKKKFEEQLNNSNNNINNSFGSDENEIENDEQDNNNNNESSNSSIEKDNNTSSSIKQRKLATPNE
Protein: Terpene synthase 2, chloroplastic ((3S,6E)-nerolidol synthase) (EC 4.2.3.48) ((E,E)-geranyllinalool synthase) (EC 4.2.3.144) (S-(+)-linalool synthase) (EC 4.2.3.25) (Q29VN2)
Organism: Zea mays (Maize)
Function: Involved in sesquiterpene (C15), diterpene (C20) and monoterpene (C10) biosynthesis. Has sesquiterpene synthase activity, converting farnesyl diphosphate to nerolidol, the precursor of the volatile C11-homoterpene (E)-3,8-dimethyl-1,4,7-nonatriene (DMNT). Has diterpene synthase activity, converting geranylgeranyl diphosphate to (E,E)-geranyllinalool, the precursor of the volatile C16-homoterpene (E,E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene (TMTT). Has monoterpene synthase activity, converting geranyl diphosphate into linalool. Forms only the S-isomers of the three tertiary terpene alcohols.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:27662898}.
Interaction partners:
- Farnesyl diphosphate synthase2
- Farnesyl diphosphate synthase3
- S-
- Farnesyl pyrophosphate synthase
- all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]
- Solanesyl diphosphate synthase 2 chloroplastic
- all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]
- Heterodimeric geranylgeranyl pyrophosphate synthase small subunit chloroplastic
- Geranylgeranyl pyrophosphate synthase1
- Geranylgeranyl pyrophosphate synthase3
Sequence:
MYSLPGATMSAAPASIISSSSFVEPLLLAAASPAAAAAAANSHHQVRQRGHLVRTLAASSSSNTLLRSDFDLQEGLTTDVKRMLRQRQKKSGGGREMLVTIDNLKRLCIDHYFEEEIEGAMATGACTRLLHSDDLFDATLAFRLLREAGHDVSAKDDVLRRFIDGASGDFKLSLSNDVRGLLSLHDMSHLDVGGEAALLHRAKEFSSRHLASAVRYLDDPSLAEYVRQSLDHPYHLSLTQYKARHHLRYLQSLPSRDAAVERLAVAEFQLNKSLHQGEMREIKRWWMDLGLAEEIPVVRDQVMKWYMWSMAALQGSSFSRYRVEITKIISLVYVVDDIFDLVGTLEELSAFTEAVKMWDTVAADSLPSCMRSCYKALHTVTNEIAEIAQKEHGSNHVNRLRKAWAVLFDGFMVEARWLATDQVPTAEDYLRNGVITSGVPLTFMHIFSMLGYDDPSTEEEEEAIIDHMPSIISCPAKILRLWDDMGSAEDEAQEGFDGSYRDFYLMENPSRSPGEAEAHMRGLIAREWEVLNRECFCRRTFPSNLVQVCLNTARMVSVMYSYNKEQRLPVLEDYAAMMLVL
Protein: Flagellar filament sheath protein (Q8F0W2)
Organism: Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Subcellular location: Periplasmic flagellum {ECO:0000256|ARBA:ARBA00004631}.
Interaction partners:
- Endoflagellar filament sheath protein
Sequence:
MRRFMNSFKITAALTTILGGVILLGIVNGQNIIKGKRGIDTATGIDVSGLELRSITVESWDNPAPSAPYGWEVTTDKDTQQPQGGQQQAYQATAQNAQALREVKLISGKPGDIKNVDAGTAKVLGVKFQFTYPGENAVTIRPPRIPEYEILRTKAYLDANNQKKVSKIYGVEFPGVSKAMSVWVCGRGNEYNLEGWIEDWKGDTHILQFGSLDFIGWRPLTVYIPQGVPQDVNSYPQVKTIVFKQFKVRSRPDTSGETVYLFFDELRVLSDVFEVHFDGASIDFDDEDCRSKHKLDKMLKTKVEKECGGGGAAGK
Protein: Electron transfer flavoprotein subunit beta (Beta-ETF) (Q0KHZ6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|PIRNR:PIRNR000090}.
Interaction partners:
- Electron transfer flavoprotein subunit alpha
- Electron transfer flavoprotein-ubiquinone oxidoreductase
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- NADH dehydrogenase 23 kDa subunit
- Succinate--CoA ligase subunit alpha, mitochondrial
- NADPH-dependent diflavin oxidoreductase 1
- D-2-hydroxyglutarate dehydrogenase, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- 3-hydroxyacyl-CoA dehydrogenase type-2
- Isovaleryl-CoA dehydrogenase, mitochondrial
Sequence:
MARVLVGVKRVIDYAVKVRVKPDKTGVVTQGVKHSMNPFDEIAVEEAVKLKEKKLAEEVIAVSVGPAQSQEVIRTALAMGADRGVHVEIPAAEYELLQPIHVSKILAKLALDEKADLVILGKQAIDDDANQTAQMTAAVLDWPQGTFCNKIEKTDAGLTITREIDGGLETIKTKTPAVLSADLRLNTPRYATLPNIMKAKKKPLKKVTAKDLGVDTSPRIEVISVEDPPVRQAGATVADVDALVAKLKEGGHI
Protein: Neuron-specific vesicular protein calcyon (P58821)
Organism: Rattus norvegicus (Rat)
Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17885599}; Single-pass membrane protein {ECO:0000269|PubMed:17885599}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- D
Sequence:
MVKLGCSFSGKPGKETGDQDGAAMDSVPLISPLDVSQLQPSFPDQVVIKTQTEYQLTSADQPKKFADLEGQRLACSHPEEGRRLPTARMIAFAMALLGCVLIMYKAIWYDQFTCPDGFLLRHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGTEMPAIWGNSYRAGKEEHKGTTPAAMTVSTAAAAAAAEGNEPSGKPLDMREKEDPQKAEDVPSQSPK
Protein: Uncharacterized NTE family protein Rv2565 (P9WIY7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Long conserved protein
- Uncharacterized protein Rv2567
Sequence:
MTTARRRPKRRGTDARTALRNVPILADIDDEQLERLATTVERRHVPANQWLFHAGEPADSIYIVDSGRFVAVAPEGHVFAEMASGDSIGDLGVIAGAARSAGVRALRDGVVWRIAAETFTDMLEATPLLQSAMLRAMARMLRQSRPAKTARRPRVIGVVSNGDTAAAPMVDAIATSLDSHGRTAVIAPPVETTSAVQEYDELVEAFSETLDRAERSNDWVLVVADRGAGDLWRHYVSAQSDRLVVLVDQRYPPDAVDSLATQRPVHLITCLAEPDPSWWDRLAPVSHHPANSDGFGALARRIAGRSLGLVMAGGGARGLAHFGVYQELTEAGVVIDRFGGTSSGAIASAAFALGMDAGDAIAAAREFIAGSDPLGDYTIPISALTRGGRVDRLVQGFFGNTLIEHLPRGFFSVSADMITGDQIIHRRGSVSGAVRASISIPGLIPPVHNGEQLLVDGGLLNNLPANVMCADTDGEVICVDLRRTFVPSKGFGLLPPIVTPPGLLRRLLTGTDNALPPLQETLLRAFDLAASTANLRELPRVAAIIEPDVSKIGVLNFKQIDAALEAGRMAARAALQAQPDLVR
Protein: BARP protein (Q38CV7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSITFHNLWLLLTVLCTAGIRADASKEECPDKGSYPAAEDVLVLCRVAEQLRGLPDTVSSALVNAATASSKAFEAKVQAEEAVELAESKGLNVTKAKEAAVRATLAAEAAATAVSYANAHGTKVGSMTEILWEADEELRELVVCKRMDEETIKAAAECTGTAEVVTAQSLSEALEALANLHYGDENVAETLRRKDVVFHKELKSLEGYVEEAVHAQKQAEDAAADANQVATGNSVASPEKSVLLLMAGLFLSSVL
Protein: DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (Q1LZ53)
Organism: Rattus norvegicus (Rat)
Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-706 in absence of DNA (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y6K1}. Chromosome {ECO:0000250|UniProtKB:Q9Y6K1}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y6K1}. Note=Accumulates in the major satellite repeats at pericentric heterochromatin. {ECO:0000250|UniProtKB:O88508}.
Interaction partners:
- DNA
- Histone deacetylase 1
- DNA
- Histone-lysine N-methyltransferase EZH2
- DNA
- Histone-lysine N-methyltransferase
- Histone-lysine N-methyltransferase SETDB1
- [histone H3]-lysine
- Histone H4
- Histone H3.3
Sequence:
MPSSGPGDTSISSLEREDDRKEGEEQEENRGKEERQEPSATARKVGRPGRKRKHPPVESSDTPKDPAVTTKSQPTAQDSGPSDLLPNGDLEKRSEPQPEEGSPAAGQKGGAPAEGEGTETPPEASRAVENGCCVTKEGRGASAGEGKEQKQTNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAVMNAVEESQASGESQKVEEASPPAVQQPTDPASPTVATTPEPVGADAGDKNATKAADDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPACHDSDESDTGKAVEVQNKQMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTTEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFIGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Protein: Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Q22037)
Organism: Caenorhabditis elegans
Function: This protein is a component of ribonucleosomes. Overexpression gradually increases telomere length, leading to increase lifespan.
Subcellular location: Nucleus. Chromosome, telomere. Note=Binds to telomeres.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein K homolog
- RNA helicase
- K Homology domain-containing protein
- RRM domain-containing protein
- Splicing factor U2AF 65 kDa subunit
- Protein lin-28
- RRM domain-containing protein
- Probable splicing factor, arginine/serine-rich 6
- ATP-dependent RNA helicase laf-1
- Probable splicing factor, arginine/serine-rich 4
Sequence:
MTDVEIKAENGSGDASLEPENLRKIFVGGLTSNTTDDLMREFYSQFGEITDIIVMRDPTTKRSRGFGFVTFSGKTEVDAAMKQRPHIIDGKTVDPKRAVPRDDKNRSESNVSTKRLYVSGVREDHTEDMLTEYFTKYGTVTKSEIILDKATQKPRGFGFVTFDDHDSVDQCVLQKSHMVNGHRCDVRKGLSKDEMSKAQMNRDRETRGGRSRDGQRGGYNGGGGGGGGWGGPAQRGGPGAYGGPGGGGQGGYGGDYGGGWGQQGGGGQGGWGGPQQQQGGGGWGQQGGGGQGGWGGPQQQQQGGWGGPQQGGGGGGWGGQGQQQGGWGGQSGAQQWAHAQGGNRNY
Protein: RE60671p (Q8MYX2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRRSINTTKSGKYMNPTDQARKEARKKELKKNKKQRQMVRAAVLKNKDPSQILEEMEKIDEMEYNVLQPSPLNEKVLRDKRKKLKETFDRVMRLYHNDEPEHWADLKRKEVEYEKKRLKKQQYYESVKHAQSVQIDEIPLPAPVSAVSGGSTETTGGSVVAGFGASVVIRLPPPPMTMALPPYAPGAPPGVSRNSDLASEAQVEKSKENEQKDWLGVPPGPPPDLFAFSELNSDAEGNTDYDGEGEEEEPEPLKKGKDKEKDKNSEATEPNNQNIDDFMKEMEHVHKRKHRKLAAKEDEADKKREEDDGKDIDKIEERTSDSDKRTASSTDDEDDDDQDEDENMPEVPTKPASVKSSTATPAPAPPTAPTLPTIPLPPASSVPAPATAATPTANS
Protein: Gibberellin receptor GID1C (EC 3.-.-.-) (AtCXE19) (Carboxylesterase 19) (GID1-like protein 3) (Protein GA INSENSITIVE DWARF 1C) (AtGID1C) (Q940G6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination and stem elongation. Partially redundant with GID1A and GID1B.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DELLA protein GAI
- DELLA protein RGA
- DELLA protein RGL1
- DELLA protein RGL2
- DELLA protein RGL3
- Gibberellin receptor GID1A
- Gibberellin receptor GID1B
- Gibberellin 3-beta-dioxygenase 1
- F-box protein GID2
- Gibberellin 20 oxidase 1
Sequence:
MAGSEEVNLIESKTVVPLNTWVLISNFKLAYNLLRRPDGTFNRHLAEFLDRKVPANANPVNGVFSFDVIIDRQTNLLSRVYRPADAGTSPSITDLQNPVDGEIVPVIVFFHGGSFAHSSANSAIYDTLCRRLVGLCGAVVVSVNYRRAPENRYPCAYDDGWAVLKWVNSSSWLRSKKDSKVRIFLAGDSSGGNIVHNVAVRAVESRIDVLGNILLNPMFGGTERTESEKRLDGKYFVTVRDRDWYWRAFLPEGEDREHPACSPFGPRSKSLEGLSFPKSLVVVAGLDLIQDWQLKYAEGLKKAGQEVKLLYLEQATIGFYLLPNNNHFHTVMDEIAAFVNAECQ