wanglab/gogpt-training-data huggingface dataset:
Protein: Myosin heavy chain kinase C (MHCK-C) (EC 2.7.11.7) (Q8MY12)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Phosphorylates threonine at 'Thr-1823', 'Thr-1833' and 'Thr-2029' in the C-terminal tail region of myosin II heavy chain (mhcA) (By similarity). This phosphorylation is critical in actin-activated ATPase activity of the myosin and regulating the assembly and disassembly of myosin II filament. In vitro, catalytic domain phosphorylates mhcA, myelin basic protein, myosin regulatory light chain, casein and caldesmon. Drives the disassembly of myosin II filaments for efficient cytokinesis and recycling of myosin II that occurs during late cytokinesis. Can be activated in vitro by autophosphorylation.
Subcellular location: Cytoplasm, cell cortex. Membrane. Cleavage furrow. Note=Localizes to the cortex of interphase cells, cleavage furrow of mitotic cells (at the late stage of cytokinesis), and posterior side of both migrating cells and daughter cells beginning to separate at the very late stage of cytokinesis. Localization is myosin II-dependent. Occasionally displays transient enrichment in pseudopodial extensions as well. {ECO:0000269|PubMed:12475956}.
Interaction partners:
- Myosin-2 heavy chain
Sequence:
MEEKKTGAAAALALLNQKFPVADVIAGTKCERAIKWELTIGDDLKPKWTHSIVCVSIEKTPFAKGSCRTAHKLKDWSQPDQGLVGKFSTNKKTTRDSYFTDVLMQTFCAKWAEKFNEAKPPKPITFLPSYVYELIDHPPPYPVCGGEPFIEGDYKKHNNNSGYVSSDARNTPQSFSHFSYELSNHELLIVDIQGVNDFYTDPQIHTKSGEGFGEGNLGETGFHKFLQTHKCNPVCDFLKLKPINQSKKALLRGTLPVVQLMDFHDAIGLNGNGSGPKNNYDMNYFRNGGGAQQPISLDDEEKMLQEQLERIRAQQQQKSKPSPPLVKQPSGNNLHKQQSPSSPTSKPVPQIVKTPSQSNVVNKSPVSPPKENSNVKLEQDNINNNNSSISSNNDNSNNNNNNNDNINNSSNSSSVNSNSSSVSSSSSSSSSSSSSSTTNAAPISIQVSRNSPPPQQPIQPSSAAASASSTSSSNVPTPESTSTSSMEQTPDRSEFEKWDLTSIKNIDTVRGLQSECITGDSLRLYSGSNDGQIGVWDAVELKHVTNIKAHGKSIRAVIKRPGFDQNILTAGADSLVKEWDINTQQTIKEIKESNEVNTIFIQDNLLYTGCNDKTVKVWDMRSYECVKTLSGHTRAIKSVCAMGNLLFSGSNDQQIYVWNLATGTILTNFQGHEGWVKTLYAHNNMLYSGSHDETIRIWDLKTTRCVNTIKCKDRVETLHVTNQGIFAGSGDWLQVFSHDKYENLASLNTRSSILCLWRNQNQLFTGSLASNLKVWSWDKM
Protein: 26S proteasome regulatory subunit RPN7 (Q06103)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- 26S proteasome regulatory subunit RPN6
- 26S proteasome regulatory subunit RPN12
- Ubiquitin carboxyl-terminal hydrolase RPN11
- 26S proteasome regulatory subunit RPN1
- 26S proteasome regulatory subunit RPN10
- Proteasome subunit alpha type-3
- 26S proteasome regulatory subunit RPN8
- 26S proteasome subunit RPT4
- Proteasome subunit alpha type-4
- Ubiquitin carboxyl-terminal hydrolase 6
Sequence:
MVDVEEKSQEVEYVDPTVNRVPNYEVSEKAFLLTQSKVSIEQRKEAAEFVLAKIKEEEMAPYYKYLCEEYLVNNGQSDLEHDEKSDSLNEWIKFDQELYNELCKKNESKIKELNEKIQKLEEDDEGELEQAQAWINLGEYYAQIGDKDNAEKTLGKSLSKAISTGAKIDVMLTIARLGFFYNDQLYVKEKLEAVNSMIEKGGDWERRNRYKTYYGIHCLAVRNFKEAAKLLVDSLATFTSIELTSYESIATYASVTGLFTLERTDLKSKVIDSPELLSLISTTAALQSISSLTISLYASDYASYFPYLLETYANVLIPCKYLNRHADFFVREMRRKVYAQLLESYKTLSLKSMASAFGVSVAFLDNDLGKFIPNKQLNCVIDRVNGIVETNRPDNKNAQYHLLVKQGDGLLTKLQKYGAAVRLTGSDRV
Protein: ER-derived vesicles protein erv14 (Q9P6K6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Regulates export of the secretory proteins from the endoplasmic reticulum in COPII-coated vesicles.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P53173}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P53173}. Note=Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles. {ECO:0000250|UniProtKB:P53173, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Methionine aminopeptidase 1
- Uncharacterized membrane protein C16E9.09c
Sequence:
MMSFGSFVYIACLLLNGANMLLQIFCVIMFSDLEMDYINPIDLCNKLNDLVMPEIISHTLVTLLLLLGKKWLLFLANLPLLVFHANQVIHKTHILDATEIFRQLGRHKRDNFIKVTFYLIMFFTLLYCMVMSLIQEE
Protein: At1g80190 (F18B13.27 protein) (Partner of SLD five 1) (Q9SSC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MYGRKGYQLIKDFATGEKGQLKPFNSKLFDETIEECDQNHHLIQSLIRKMQQEGLDVQNNRNADHYGALIHHLALIRNKRCLMAYVYNRAEIVRDLAWRVGLELLDLPSEIQEKLTTLEKEYFKNHSVALKSYMGKVGIELNVDMVPPKDPYIKVRILDDIDEGIVLSDKTTNFARHSMHFLKRTDAEPYIARGQMEELTG
Protein: Probable receptor-like protein kinase At5g39030 (EC 2.7.11.-) (Q9FID5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Probable serine/threonine protein kinase IRE3
- Uncharacterized protein
- Uncharacterized protein
- F18K10.11 protein
- Cyclase-associated protein 1
- Expressed protein
- At1g65370/T8F5_15
- tRNA
- GPI-anchored protein LLG3
- GPI-anchored protein LLG2
Sequence:
MICFILFVFSFLVSVSATAPYKPDDVFLINCGETDVPFDNHGRTWTQEEKNILPKNSDNASFSSVVSYKEESGIPQVPYMTARIFRSDFTYSFPVSPGWKFLRLYFYPTSYKSGFDAVNSFVSVTVNDFTLLQNFSADLTVKASIPESKSLIKEFIVPVYLTLNLTFRPSNNSLAFVNGIEIVSMPDRFYSKGGFDDLITNVGSLIDFEIDNSTASETVHRLNVGGHMVDEVNDSGMFRRWLSDDYEFLIGGVSPYMPDVNISYTEKTPAYVAPAYVYSTCRMMGNAQDTYLNLNFNLTWLFTVDAGFSYLVRLHFFEKYLNKANQRVFSIFLGNQMAREEMDVIRLSGGPRIPIYLDFRIYVGSESGPRPDLRLDLHPLVKDNPEYYEAILNGVEILKLNNSGNLAIIQDNELKPNPPLSSNLTPNHVTQQIKGKSSHLLVKIFIAVGPGTGLATFVVVLMLWMRQMKRKNRKEERVVMFKKLLNMYTYAELKKITKSFSYIIGKGGFGTVYGGNLSNGRKVAVKVLKDLKGSAEDFINEVASMSQTSHVNIVSLLGFCFEGSKRAIVYEFLENGSLDQFMSRNKSLTQDVTTLYGIALGIARGLEYLHYGCKTRIVHFDIKPQNILLDGNLCPKVSDFGLAKLCEKRESVLSLMDTRGTIGYIAPEVFSRMYGRVSHKSDVYSFGMLVIDMIGARSKEIVETVDSAASSTYFPDWIYKDLEDGEQTWIFGDEITKEEKEIAKKMIVVGLWCIQPCPSDRPSMNRVVEMMEGSLDALEIPPKPSMHISTEVITESSSLSDGGEDV
Protein: General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (Q4G005)
Organism: Rattus norvegicus (Rat)
Function: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIH subunit 2
- General transcription and DNA repair factor IIH subunit TFB5
- General transcription factor IIH subunit 4
- General transcription factor IIH subunit 1
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIE subunit 1
- General transcription factor IIH subunit 3
- Transcription initiation factor IIE subunit beta
- Cyclin-H
Sequence:
MGKRDRVDRDKKKSKKRQYEEEEEDEDDAPGNESQEAVPSAAGKQVDESSTKVDEYGAKDYRQQMPLKGDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIIQFIKLCTVSYGKVKLVLKHNRYFVESSHPDVIQHLLQDPVIRECRLRNAEGEATELITETFTSKSAISKTVEGSGGASTSQGVDAQAKSDIPKDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCICLEYPLLAEYDFRNDSLNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSIAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEELAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSGQASRRFGTMSSLSGADDTVYMEYHSSRNKASTKHVHPLFKRFRK
Protein: CDT1-like protein b (AtCDT1b) (Q9M1S9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Member of the pre-replication complex. Regulates endoreduplication. Involved in the coordination of cell and plastid division.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA replication licensing factor MCM5
- Origin of replication complex subunit 1A
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM7
- Cell division control protein 6 homolog B
- Origin of replication complex subunit 2
- Cell division control protein 6 homolog
- DNA replication licensing factor MCM3
- Origin of replication complex subunit 1B
- Origin of replication complex subunit 5
Sequence:
MSSSSKIDSEKPVMVSESLFSTKTPIKTVKRQIFSSSPKPESVIKLPERFEILEEFFNGLDTAIRLLKLKGSSTTYANICPKIEYLTNRIFSYDHLAQMKHIYPEAIELKRVLKFVEDTCCMKPRLHIKLNTDAIVVEDTICGTKYMELRKVFHSKLVDFRKAHPKDEIPKELLPEPFNSPQRDSYSGIVSVGLGEPKLEVGGFDVHMEEIEQEEQDVNKVIPDSTLSHIESRIVETPVKDLSTPSKDLSTPIRLMSATPTLQLSKRCIELTPEGGDDNSLRSTNSLARGPSRSLNFDTFEEDAIEKDDIGNESDDKGINYEEDGLLQSVKGPSRSLNFDTLEEETIVKDDISNESGDEKSNYEGDNASDDDSLLQSMIERPKTEPEKHNLPQLVNLIHRVFHSTNRTVITKEELLYKIIANQINITDRREVEEQLSLMLQLVPDWISETKASSGDLLVRINKMSTAETVRARLEEATSHDISLIY
Protein: Uncharacterized protein (Q38DX7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Vta1/callose synthase N-terminal domain-containing protein
- Katanin, putative
- Vacuolar transport protein 4A, putative
- Class-E vacuolar protein-sorting protein 24
- Uncharacterized protein
- Vesicular protein trafficking mediator, putative
- IST1 homolog
- Charged multivesicular body protein 6
- SNF-7-like protein, putative
Sequence:
MSVNQLQDLHFQLKYVVKQFNKNSTRCEKEQKAELGKCKKAMAKGNMDIARIFAENSIRKRNESLSHLRLASRMDAVVSRLDTAIKMNKVTRGMSQMVHGMDKVVQSMNPEKISELMEKFEKQFETMDVASEYMETAIGQTTSTSMPEDEVSLLLLQVAEEEGLAVKEELFNKAKLPQQQPVAPEATKLAEPDLDELSARLDMLRGK
Protein: Respiratory burst oxidase homolog protein C (EC 1.11.1.-) (EC 1.6.3.-) (NADPH oxidase RBOHC) (AtRBOHC) (Protein ROOT HAIR DEFECTIVE 2) (O81210)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Calcium-dependent NADPH oxidase that generates superoxide. Required for H(2)O(2) production in response to K(+) deficiency and for the generation of reactive oxygen species (ROS) that regulate cell expansion through the activation of Ca(2+) channels.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Rac-like GTP-binding protein ARAC4
- Transcription factor RHD6
- Transcription factor RSL3
- Rho GDP-dissociation inhibitor 1
- Rac-like GTP-binding protein ARAC3
- Calcium-dependent protein kinase 7
- Transcription factor UPBEAT1
- Calcium-dependent protein kinase 3
- Calcium-dependent protein kinase 16
- Kinesin-like protein KIN-UC
Sequence:
MSRVSFEVSGGYHSDAEAGNSGPMSGGQLPPIYKKPGNSRFTAENSQRTRTAPYVDLTVDVQDDTVSVHSLKMEGGSSVEESPELTLLKRNRLEKKTTVVKRLASVSHELKRLTSVSGGIGGRKPPRPAKLDRTKSAASQALKGLKFISKTDGGAGWSAVEKRFNQITATTGGLLLRTKFGECIGMTSKDFALELFDALARRRNITGEVIDGDQLKEFWEQINDQSFDSRLKTFFDMVDKDADGRLTEDEVREIISLSASANNLSTIQKRADEYAALIMEELDPDNIGYIMLESLETLLLQAATQSVITSTGERKNLSHMMSQRLKPTFNRNPLKRWYRGLRFFLLDNWQRCWVIVLWFIVMAILFTYKYIQYRRSPVYPVMGDCVCMAKGAAETVKLNMALILLPVCRNTITWLRNKTRLGRVVPFDDNLNFHKVIAVGIIVGVTMHAGAHLACDFPRLLHATPEAYRPLRQFFGDEQPKSYWHFVNSVEGITGLVMVLLMAIAFTLATPWFRRGKLNYLPGPLKKLASFNAFWYTHHLFVIVYILLVAHGYYLYLTRDWHNKTTWMYLVVPVVLYACERLIRAFRSSIKAVTIRKVAVYPGNVLAIHLSRPQNFKYKSGQYMFVNCAAVSPFEWHPFSITSAPQDDYLSVHIRVLGDWTRALKGVFSEVCKPPPAGVSGLLRADMLHGANNPDFPKVLIDGPYGAPAQDYKKYEVVLLVGLGIGATPMISIVKDIVNNIKAKEQAQLNRMENGTSEPQRSKKESFRTRRAYFYWVTREQGSFDWFKNIMNEVAERDANRVIEMHNYCTSVYEEGDARSALIHMLQSLNHAKNGVDIVSGTRVMSHFAKPNWRNVYKRIAMDHPNTKVGVFYCGAPALTKELRHLALDFTHKTSTRFSFHKENF
Protein: Protein A52 (Q01220)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Bcl-2-like protein which targets host toll-like receptor signaling complexes to suppress innate immune response. Interacts with host TRAF6 to activate p38 and subsequently induce the expression of several cytokines such as IL-10. Associates also with host IRAK2 to inhibit NF-kappa-B signaling.
Interaction partners:
Sequence:
MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMFTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS
Protein: Regulatory protein SIR4 (Silent information regulator 4) (P11978)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
Subcellular location: Nucleus.
Interaction partners:
- Silent chromatin protein ESC1
- Regulatory protein SIR1
- NAD-dependent histone deacetylase SIR2
- Regulatory protein SIR3
- ATP-dependent DNA helicase II subunit 2
- ATP-dependent DNA helicase II subunit 1
- DNA-binding protein RAP1
- Origin recognition complex subunit 2
- Spindle pole body assembly component MPS3
- Histone H4
Sequence:
MPNDNKTPNRSSTPKFTKKPVTPNDKIPEREEKSNEVKTPKIPLFTFAKSKNYSRPSTAIHTSPHQPSDVKPTSHKQLQQPKSSPLKKNNYNSFPHSNLEKISNSKLLSLLRSKTSAGRIESNNPSHDASRSLASFEQTAFSRHAQQQTSTFNSKPVRTIVPISTSQTNNSFLSGVKSLLSEEKIRDYSKEILGINLANEQPVLEKPLKKGSADIGASVISLTKDKSIRKDTVEEKKEEKLNIGKNFAHSDSLSVPKVSAGDSGISPEESKARSPGIAKPNAIQTEVYGINEESTNERLEINQEKPVKLDENSANSTVASALDTNGTSATTETLTSKKIVPSPKKVAIDQDKITLHDEKTLAPSKHQPITSEQKMKEDADLKRMEILKSPHLSKSPADRPQGRRNSRNFSTRDEETTKLAFLVEYEGQENNYNSTSRSTEKKNDMNTSAKNKNGENKKIGKRPPEIMSTEAHVNKVTEETTKQIQSVRIDGRKVLQKVQGESHIDSRNNTLNVTPSKRPQLGEIPNPMKKHKPNEGRTPNISNGTINIQKKLEPKEIVRDILHTKESSNEAKKTIQNPLNKSQNTALPSTHKVTQKKDIKIGTNDLFQVESAPKISSEIDRENVKSKDEPVSKAVESKSLLNLFSNVLKAPFIKSESKPFSSDALSKEKANFLETIASTEKPENKTDKVSLSQPVSASKHEYSDNFPVSLSQPSKKSFANHTEDEQIEKKKICRGRMNTIITHPGKMELVYVSDSDDSSSDNDSLTDLESLSSGESNEIKVTNDLDTSAEKDQIQAGKWFDPVLDWRKSDRELTKNILWRIADKTTYDKETITDLIEQGIPKHSYLSGNPLTSVTNDICSVENYETSSAFFYQQVHKKDRLQYLPLYAVSTFENTNNTEKNDVTNKNINIGKHSQEQNSSSAKPSQIPTVSSPLGFEETKLSTTPTKSNRRVSHSDTNSSKPKNTKENLSKSSWRQEWLANLKLISVSLVDEFPSELSDSDRQIINEKMQLLKDIFANNLKSAISNNFRESDIIILKGEIEDYPMSSEIKIYYNELQNKPDAKKARFWSFMKTQRFVSNMGFDIQKSCEPVSISTSVKPHVVEPEHMADAKIMPKDILQITKKPLMVKNVKPSSPPDVKSLVQLSTMETKTLPEKKQFDSIFNSNKAKIIPGNGKHASENISLSFSRPASYGYFSVGKRVPIVEDRRVKQLDDITDSNTTEILTSVDVLGTHSQTGTQQSNMYTSTQKTELEIDNKDSVTECSKDMKEDGLSFVDIVLSKAASALDEKEKQLAVANEIIRSLSDEVMRNEIRITSLQGDLTFTKKCLENARSQISEKDAKINKLMEKDFQVNKEIKPY
Protein: IQ calmodulin-binding motif family protein (Q580S4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPPPALPTIRHPSGLQKPPLPAIRKPTMDDGVARMLETGNLSADVDLEEFFNKEGVFKAVKAPVHPVKERQLPRVMTKTSSYARYNGVLLDIEDIRKIPPKLNLQDLREWENGVDDDDDASDVTSSLYGTVLKNAGEIMTHLQAPQRNDTRTYVELLDEYSMHEFIIRKGMTLRNTPEFASFKRRYNSCWGNIEHIVVKLENFLKMYNVELAFVDGRKVAELAAFQVDDILKREDLLQCFANHEEVEEMTANVSQLYAAADSGRKLAVEKIQATWRMYQQRIAYRHLLDGKKAATTVQRAWTLYRLHCTTRKTIKALRETRLLRWKHTMEEFIRKWPKIRDGPRRIIHVPSLSYPRFHAKHVPFYLLLQMGQIIRVSDLKDPNVEIILIVPMRPEPEILEYYYSMLASAGVPDVKSRLTLLVPEEAKRLPGVLSLTRLMLLSSRLMKCLASASKGRDTYIVPGVVGAEELSLATELNVPMLSADPNIAQAFGTKSGGRRLMDLAAVPAPPGAHGLNDRNDLLSALALLMVNYREVSRWLVKLDTESGSRGHAYFDVNRIHVMAGVDESKKTYENVLAELKQHAGKRARLLNPLSYSDWEAYLNMFDVVGGCVEAVPNRIKTSLTANLFVEPSGVVAVNSVVEPMLAPAFTVIGCQYPFSKVVPYAAVRDAALALAKAAYHKGIMGYMSVDFVVTDVSENSLPRLYAVDVDLCLTNNAAAHSFACLVAGCEWNAEEGTCLFRGTANSLSYAYSGLIYSPLLASVRHKSFFTLCHRKGLTFDSQLQSGIVYHLLSIITCGCVGVLSLGTQRNVVARKMKEFQSLLNLELPKQGEHTGESNIMYFYSATHQLVRSVQVSEMK
Protein: Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2) (Q8CGU9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Pterin-4-alpha-carbinolamine dehydratase
- 4a-hydroxytetrahydrobiopterin dehydratase
- Aromatic-L-amino-acid decarboxylase
- Indoleamine 2,3-dioxygenase 2
- Dihydropteridine reductase
- Indoleamine 2,3-dioxygenase 1
- Sepiapterin reductase
- Tryptophan 2,3-dioxygenase
- Tryptophan 5-hydroxylase 1
- aldose reductase
Sequence:
MQPAMMMFSSKYWARRGLSLDSAVPEEHQILGGLTQNKATASKSEDKRSGKDTSESSKTAVVFSLKNEVGGLVRALRLFQEKHVNMLHIESRRSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPDNIWTEEEELEDVPWFPRKISELDRCSHRVLMYGTELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQDAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
Protein: Xylan alpha-(1->2)-glucuronosidase (EC 3.2.1.131) (Alpha-glucuronidase) (Q09LY5)
Organism: Geobacillus stearothermophilus (Bacillus stearothermophilus)
Function: Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. It catalyzes the cleavage of alpha-1,2-glycosidic bond of the 4-O-methyl-D-glucuronic acid side chain of xylan and releases 4-O-methylglucuronic acid from xylan.
Interaction partners:
Sequence:
MTAGYEPCWLRYERKDQYSRLRFEEIVAKRTSPIFQAVVEELQKGLRSMMEIEPQVVQEVNETANSIWLGTLEDEEFERPLEGTLVHPEGYVIRSDVDDGPFRIYIIGKTDAGVLYGVFHFLRLLQMGENIAQLSIIEQPKNRLRMINHWDNMDGSIERGYAGRSIFFVDDQFVKQNQRIKDYARLLASVGINAISINNVNVHKTETKLITDHFLPDVAEVADIFRTYGIKTFLSINYASPIEIGGLPTADPLDPEVRRWWKETAKRIYQYIPDFGGFVVKADSEFRPGPFTYGRDHAEGANMLAEALAPFGGLVIWRCFVYNCQQDWRDRTTDRAKAAYDHFKPLDGQFRENVILQIKNGPMDFQVREPVSPLFGAMPKTNQMMEVQITQEYTGQQKHLCFLIPQWKEVLDFDTYAKGKGSEVKKVIDGSLFDYRYSGIAGVSNIGSDPNWTGHTLAQANLYGFGRLAWNPDLSAEEIANEWVVQTFGDDSQVVETISWMLLSSWRIYENYTSPLGVGWMVNPGHHYGPNVDGYEYSHWGTYHYADRDGIGVDRTVATGTGYTAQYFPENAAMYESLDTCPDELLLFFHHVPYTHRLHSGETVIQHIYNTHFEGVEQAKQLRKRWEQLKGKIDEKRYHDVLERLTIQVEHAKEWRDVINTYFYRKSGIDDQYGRKIYR
Protein: Rho-related BTB domain-containing protein 1 (Q9DAK3)
Organism: Mus musculus (Mouse)
Interaction partners:
- Cullin-3
- Kelch-like ECH-associated protein 1
- Kelch-like protein 9
- Kelch-like protein 13
- Rho-related BTB domain-containing protein 2
- Intersectin-2
- Intersectin-1
- Rho-associated protein kinase 2
- Rho-associated protein kinase 1
Sequence:
MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSISLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSAGTSDAACLLDNPLCADVLFVLHDEEHIFAHRIYLATSSSKFYDLFLMECEESPCWGGGAGEEVPCRDFQGRTQSLGSAEEGKEGPQRTPQADPGASSGQDLPESLALQMEASGSEGHALSGWSKGFVSMHREVRVNPISKRVGPVTVVRLDPSMQSGPFRTLLRFLYSGQLDEKEKDLLGLAQMAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFTLDDGAISAHKPLLICSCEWMAAMFGGSFVESANREVHLPNINKMSMQAVLEYLYTKQLSPNLDLDPLELIALANRFCLTHLVALVEQHAVQELTKAAVSGVSIDGEVLSYLELAQFHNANQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDLALNKHHSRRKWCFWHSSPAVA
Protein: Glutathione S-transferase D1 (EC 2.5.1.18) (EC 4.5.1.1) (DDT-dehydrochlorinase) (P20432)
Organism: Drosophila melanogaster (Fruit fly)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification.
Interaction partners:
- Glutathione S transferase D8
- Glutathione S-transferase D7
- Glutathione S transferase D10, isoform A
- Glutathione S-transferase D2
- Glutathione S-transferase D4
- Glutathione S-transferase S1
- Glutathione S-transferase D5
- Bifunctional glutamate/proline--tRNA ligase
- Glutathione S transferase D9, isoform A
- Glyceraldehyde-3-phosphate dehydrogenase 2
Sequence:
MVDFYYLPGSSPCRSVIMTAKAVGVELNKKLLNLQAGEHLKPEFLKINPQHTIPTLVDNGFALWESRAIQVYLVEKYGKTDSLYPKCPKKRAVINQRLYFDMGTLYQSFANYYYPQVFAKAPADPEAFKKIEAAFEFLNTFLEGQDYAAGDSLTVADIALVATVSTFEVAKFEISKYANVNRWYENAKKVTPGWEENWAGCLEFKKYFE
Protein: Protein MOTHER of FT and TFL1 (Q9XFK7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May form complexes with phosphorylated ligands by interfering with kinases and their effectors (By similarity). Regulates seed germination via the abscisic acid (ABA) and gibberellic acid (GA)signaling pathways. During seed germination, MFT expression is directly repressed by ABI3 or promoted by ABI5 in the ABA signaling pathway. Involved in a negative feedback regulation of ABA signaling. Promotes embryo growth by direct repression of ABI5. In the GA signaling pathway, MFT expression is promoted by the DELLA protein RGL2 during seed germination. May regulate seed germination and fertility through the brassinosteroid (BR) signaling pathway.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- UPF0235 protein At5g63440
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein mL46
- At1g64880
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein bL34m
- Large ribosomal subunit protein uL5c
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- 50S ribosomal protein L33
Sequence:
MAASVDPLVVGRVIGDVLDMFIPTANMSVYFGPKHITNGCEIKPSTAVNPPKVNISGHSDELYTLVMTDPDAPSPSEPNMREWVHWIVVDIPGGTNPSRGKEILPYMEPRPPVGIHRYILVLFRQNSPVGLMVQQPPSRANFSTRMFAGHFDLGLPVATVYFNAQKEPASRRR
Protein: Alphabet, isoform E (EC 3.1.3.16) (LD23542p) (Q961C5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}.
Interaction partners:
- Mitogen-activated protein kinase kinase kinase
- Mitogen-activated protein kinase kinase kinase 7
- FI16976p1
- Putative mitogen-activated protein kinase kinase kinase 7-like
- CG6036 protein
- Mothers against decapentaplegic homolog
- Mothers against decapentaplegic homolog
Sequence:
MGGFLDKPKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGDALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKGIRTGFLRIDEVMRELPEFTRESEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDFKNVKEKGQCEQLVSPEPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNMSIIIIAFPGAPKPTEEAIEAEHRLEKQIEKITRDEIESSKITDYVDLLKCLQNRDDIEGLPPGGGLQSKYHVIERTFKQEFPDRPCEGNGISYFIPF
Protein: Outstretched (Unpaired 1, isoform A) (Unpaired 1, isoform B) (Unpaired 1, isoform C) (Q9VWW4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cytokine receptor
- Signal transducer and transcription activator
- Tyrosine-protein kinase hopscotch
- Unpaired 2
- FI03911p
- Suppressor of cytokine signaling at 36E, isoform D
- Epidermal growth factor receptor
Sequence:
MARPLLLLLPILLVLLLAAQLPHLAEGRSTTSSGGLTVIDSERLRIRTTSSTASAQHPNQGTIPASAASPRKRHRKRNSNWIDYRNFDENTTALEWANPCGGNYHPSAGDRFNRQRPRQSFNQLKRHAFREYRSLNSSQDSAIDIRNMTMWSLHTHNYKFLPKLKPNSTIALKRWYRNMQTYVASFAYLRRQQIRWDQRSITRESSTARELRELLLSSRRILCELETAVNQTQSPRQKQRRSGAAVTAVGGTTMLGQQLPQISRLEMNKRLKLRSKTSGPGMGGAASSASMAAGEADSIDMRFVKHHYYDFLRTMYQLLRRDGKRVRSRPRKHHKKQQRSQKKLLQQQQQLADQLEQRWRSSTLNGKEFNEVSKPVAGGAAGVADVAGVSGGGSNQFARGRRGKRQSKRVQRT
Protein: Histone acetyltransferase (EC 2.3.1.48) (M9NEW2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361211}.
Interaction partners:
Sequence:
MALESGSSSSESGSSSTSGSTSSETGSSSDTDSSSATPEEKPSTNSSAKSQTQTQQQTNSGNAQRRKPVPAASEDKPKPSVAPSSKKVNNPPKSKLSSDDDEYEDSAPPAKKNSRAMGSSTVTAAAAASAARRKPPASVNKPSNPANKPSNPTQRSANNNTNRSLENGEGKRPSLSSSSNSTDDSMKIVKNGRKVPLKMASTVRPKQIRGKLPPAKKNGGGPVISSDGSSGSESGSNSGDESSSGSESEGSDSSNSYSSQPVKGGAKGKRSGPTKIQNSDSEEERKDKANPMRKLTRSLSMRRTKQQPKQETDSESDGDLEDDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVSPITQTEKKCPIEGCDSSGHLSGNLDKHFLPEACPIYHNMSASECKERANERKLRNEQRLKMPVNIVTAPGNQNTNLKTLSPEQREFLAKIRESRANFKPANNNFLDSKVKLEKDVTDEDREPNLAGLVPDYDLQLFREAQAQASERIEDELKDLPVGKGIKYISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDGCHIVGYFSKHIPFLQEKNSFYNVSCILTLPPYQRKGYGRLLIDFIYNHSAIKCIELVLL