wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase MARCHF2 (EC 2.3.2.27) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172) (RING-type E3 ubiquitin transferase MARCHF2) (Q9P0N8)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR. Ubiquitinates and therefore mediates the degradation of DLG1. Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3. Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteosomal degradation. May be involved in endosomal trafficking through interaction with STX6.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:23166351}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Golgi apparatus membrane {ECO:0000269|PubMed:23818989}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:32935379}. Cell membrane {ECO:0000269|PubMed:32935379}; Multi-pass membrane protein {ECO:0000269|PubMed:32935379}.
Interaction partners:
- Syntaxin-6
- E3 ubiquitin-protein ligase MARCHF5
- Trans-Golgi network integral membrane protein 2
- Ubiquitin-conjugating enzyme E2 H
Sequence:
MTTGDCCHLPGSLCDCSGSPAFSKVVEATGLGPPQYVAQVTSRDGRLLSTVIRALDTPSDGPFCRICHEGANGECLLSPCGCTGTLGAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPRPLTEWLKDPGPRTEKRTLCCDMVCFLFITPLAAISGWLCLRGAQDHLRLHSQLEAVGLIALTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKIREADSPEGPQHSPLAAGLLKKVAEETPV
Protein: Hemolysin III (Q8IKS4)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEFYKNFFSHFTNTFNSEYIFDLKGSTKIDDNEIASFIKSNDLCENDKKIVELYIEKKINKIMLIKYMERKNKTLFRGKIHLMLVFISPLWIFYMLYLSKTLTARIFTSIAVLCIFFNFFASFLLHNFEWKPKFFFIIEKMDHFGIFLMISGSLLPVQALLFNKIKLLFFISLQFFAILFGCLIVFFSCFSSGNRFIRSMIFTIAGLLHIIFIRDYVSLLYGKEFILLILLGVLYIIGAVIYSVKKPNIFPGILEFHEVFHICCLGSAVCTFVLNCSVIKRT
Protein: Chloride channel 2c (Chloride channel protein 2c) (Clc-2c chloride channel) (E7FCE2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Solute carrier family 12 member 10, tandem duplicate 2
- Family with sequence similarity 131 member A.
- Uncharacterized protein.
- Sodium/potassium-transporting ATPase subunit alpha.
- Anion exchange protein.
- Nucleic acid-binding protein 1b.
- Cytochrome P450 2X10.2 isoform 2
- Cytochrome P450 2F2-like
- ADP-ribosylation factor-like 4Ca
- Organic solute transporter subunit alpha
Sequence:
MENKGTDENDLERGIYTKSADRLGKGHCHRKSELNQSNNCGVWIVHFHRLFVSLIGADWIFLMILGFILGTISFLMDIFVDLFTDAHRWIYYSVADYHVVVQYLVWVSYSMILMCFAAGFANIVSPQAVGSGIPEMKTALRGVVMQEYLTFRTLVSKVVSLTCVLGSELPVGKEGPFVHIGSLCASLLCKFMALFSNIYKNEARNKELLTVGCAVGIGCCFASPIGGALFSIEVTAMYYLPRNYWRAFLSATFGAIIFRLLPVWHREEETLMALYATKYRLDFPFDLQELPVFVAMGIVCGLGGAFFVFLYGKITLFVKEKKASNSLLMRNCFYYSALTSVLISTLTFPPGFGQFMAGKLTQRYSLISFFDDRTWSNHSIVKDFDDNDHLAAWKHPYANVFVVLFVFVIMKFWMSALSITLPIPCGSFVPIFVIGAGFGRLIGEGMATLFPEGFNTDGHIYPIVPGAYAVVGAAALTAGVTHTMSTAVIMMELTGHLSYSLPILISVILSNMVSQSLQPSIYDTVIRIKRLPYLPLLRWGQRENSKIHVEDFMNRDVRFITLNSTYRDVFKILCSGNLKTVPMVKSTESMLLLGSIERAQLLALLIERTQYLRGGAYSIPARSKVHFQTATEDSSSASAQVSPSTPLKSALKRPTADEEQLNNNVYDSGLSFKTFFCSRPDTDAMKNDPDAHDDMILQEIEKWEEQQLDEQVNFNSCQIDPAPFQLVDRTTLHKTHSMFSVLNLDYAFVTSVGRLVGVVSLNELCKAITGCMPPDGVSLSPILSGFRERGSAGWRPEVCELHKLLDHQDC
Protein: Putative acyl-CoA dehydrogenase AidB (EC 1.3.99.-) (P33224)
Organism: Escherichia coli (strain K12)
Function: Part of the adaptive DNA-repair response to alkylating agents. Could prevent alkylation damage by protecting DNA and destroying alkylating agents that have yet to reach their DNA target. Binds to double-stranded DNA with a preference for a DNA region that includes its own promoter. Shows weak isovaleryl-CoA dehydrogenase activity in vitro.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- DNA-3-methyladenine glycosylase 2
- NADH-quinone oxidoreductase subunit C/D
- Fatty acid oxidation complex subunit alpha
- Alpha-ketoglutarate-dependent dioxygenase AlkB
- Fatty acid oxidation complex subunit alpha
- Glutaminase 1
- Methylated-DNA--protein-cysteine methyltransferase
- Putative electron transfer flavoprotein subunit YdiR
- Chaperone modulatory protein CbpM
- Curved DNA-binding protein
Sequence:
MHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAESLELGRLANVNPPELLRYDAQGRRLDDVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPLLSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTAGGLSCFFVPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGLEGEGIRLILKMGGMTRFDCALGSHAMMRRAFSLAIYHAHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLARAWDRRADAKEALWARLFTPAAKFVICKRGMPFVAEAMEVLGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEELGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRATGGVCV
Protein: Transcription factor Sp3 (H0Y6K5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
IGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME
Protein: Bacteriophage encoded virulence factor (Virulence protein) (A0A0H3N9Y3)
Organism: Salmonella typhimurium (strain SL1344)
Interaction partners:
Sequence:
MLRHIQNSLGSVYRSNTATPQGQIIHHRNFQSQFDTTGNTLYNNCWVCSLNVIKSRDGNNYSALEDITSDNQAFNNILEGIDIIECENLLKEMNVQKIPESSLFTNIKEALQAEVFNSTVEDDFESFISYELQNHGPLMLIRPSLGSECLHAECIVGYDSEVKKVLIYDSMNTSPEWQSNIDVYDKLTLAFNDKYKNEDCSICGLYYDGVYEPKPLHSSSWKDWCTIL
Protein: Copine-1 (Chromobindin 17) (Copine I) (Q99829)
Organism: Homo sapiens (Human)
Function: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.
Subcellular location: Nucleus {ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:21087455}. Cytoplasm {ECO:0000269|PubMed:12949241, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}. Cell membrane {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385). {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}.
Interaction partners:
Sequence:
MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGDGKWHLVYRSEVIKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPAQAPQA
Protein: Tyrosinase copper-binding domain-containing protein (Q5AQP2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- histidinol-phosphate transaminase
- aspartate transaminase
- aromatic-amino-acid transaminase
- Aspartate aminotransferase
- Aromatic-amino-acid transaminase, hypothetical
- Aspartate aminotransferase
- Aromatic-L-amino-acid decarboxylase, putative
Sequence:
MRLAGVLFSLALLHLASGVPHGSRTTCSNPPVRKEWRQLSAEEKAEYIAAVQCLTTLDPKSGLDGTANRFDDFQAVHSNQTPSIHWVGHFALWHRYFVASYEKSLREECGYTGAQPYWNWSLDASTNLSSTAIFETEIFDPDTGFGGNGAWVEITDPADNPFNLTGRTGGGCVKTGPFTPDKFQLHHSGGGCLKRDFIPWIMNSFAAQSLVDWVQSQPDYTSFARALENIPDFSEPNIHGSGHFGAGGVLGTLGNQYESPGDPLFYLHHGNLDRILWEWQQQDLPTRLHQVGGPIEPLDYSGKNVTLDFTVNIGALAGNATLEQLLSTNGDVLCYTYDTA
Protein: Pheromone-regulated membrane protein 3 (Q08931)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the fusion of nuclear envelopes during mating, ensuring proper karyogamy. Plays a role in the initiation of outer nuclear envelope fusion.
Subcellular location: Nucleus outer membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Interaction partners:
- Nuclear fusion protein KAR5
- DnaJ-like chaperone JEM1
Sequence:
MTAMKEDNAALITLKKNNDQEKLRVHKLTDASSNSADGFVINKAKNGGPLNKKSLVNNEQHIKKAVSPGRVRKHKTTTSSTKSRTKSKKKDASESKVQRENKGSFYQGAIFGSFLGAAVTTVLSNLAVKALQN
Protein: SWN5 (I1J3T2)
Organism: Brachypodium distachyon (Purple false brome) (Trachynia distachya)
Interaction partners:
Sequence:
MEHLQQQQDDQSCCVPPGFRFHPTEEELVGYYLARKVASQKIDLDIIQEVDLYRIEPWDLQERCGRQYGAGSGHEEDSFRSSSSSAEWYFFSFKDRKYPSGTRTNRATAAGFWKATGRDKPVLRGGHGHGRGAVIGMRKTLVFYRGRAPNGRKTEWIMHEYRLQSSEHAPTPEEGWVVCRAFHKPLPNMHHHRPMPFVFPGADHYAAAAGGPPPAGYYINDIDARLNGHGGDLLNYLHPAPVSGGGGGGFVFPGNGSVHGQMIVSEDLQVESKKHVNIFSSIPQLIESPVTATIDDDDQAGAGQQAAGGIDWNFLDSLLSSTSSASQLIHDSSSQSQLMMHLQQQH
Protein: Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Q8IHU9)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Endoplasmic reticulum {ECO:0000256|RuleBase:RU365083}.
Interaction partners:
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- mannose-1-phosphate guanylyltransferase
- GDP-L-fucose synthase
- GDP-mannose 4,6-dehydratase
- Mannosyltransferase
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, putative
- GPI mannosyltransferase 2
- Methionyl-tRNA formyltransferase, putative
- GPI mannosyltransferase 1
- dolichyl-diphosphooligosaccharide--protein glycotransferase
Sequence:
MVIRFFLFVITLLGLCINMVCCNFKYSIILPTYNEKENLPYLIYMIIDELNKHEIKFEIIVIDDNSQDGTADVYKKLQNIFKDEELLLIQRKGKLGLGSAYMEGLKNVTGDFVIIMDADLSHHPKYIYNFIKKQREKNCDIVTGTRYKNQGGISGWSFNRIIISRVANFLAQFLLFINLSDLTGSFRLYKTNVLKELMQSINNTGYVFQMEVLVRAYKMGKSIEEVGYVFVDRLFGKSKLETTDILQYLSGLFKLFWSI
Protein: Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) (P71741)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the hydrolysis of alpha,alpha-trehalose into two molecules of D-glucose.
Interaction partners:
- Trehalose-phosphate phosphatase
- Trehalose synthase/amylase TreS
- Malto-oligosyltrehalose trehalohydrolase
- Uncharacterized glycosyl hydrolase Rv2006
- Trehalose-6-phosphate synthase
- Uncharacterized glycosyl hydrolase Rv3401
- Putative maltooligosyl trehalose synthase
- Possible conserved membrane protein
Sequence:
MVLHAQPPDQSTETAREAKALAGATDGATATSADLHAPMALSSSSPLRNPFPPIADYAFLSDWETTCLISPAGSVEWLCVPRPDSPSVFGAILDRSAGHFRLGPYGVSVPSARRYLPGSLIMETTWQTHTGWLIVRDALVMGKWHDIERRSRTHRRTPMDWDAEHILLRTVRCVSGTVELMMSCEPAFDYHRLGATWEYSAEAYGEAIARANTEPDAHPTLRLTTNLRIGLEGREARARTRMKEGDDVFVALSWTKHPPPQTYDEAADKMWQTTECWRQWINIGNFPDHPWRAYLQRSALTLKGLTYSPTGALLAASTTSLPETPRGERNWDYRYAWIRDSTFALWGLYTLGLDREADDFFAFIADVSGANNNERHPLQVMYGVGGERSLVEAELHHLSGYDHARPVRIGNGAYNQRQHDIWGSILDSFYLHAKSREQVPENLWPVLKRQVEEAIKHWREPDRGIWEVRGEPQHFTSSKVMCWVALDRGAKLAERQGEKSYAQQWRAIADEIKADILEHGVDSRGVFTQRYGDEALDASLLLVVLTRFLPPDDPRVRNTVLAIADELTEDGLVLRYRVHETDDGLSGEEGTFTICSFWLVSALVEIGEVGRAKRLCERLLSFASPLLLYAEEIEPRSGRHLGNFPQAFTHLALINAVVHVIRAEEEADSSGMFQPANAPM
Protein: Cullin-4 (AtCUL4) (Q8LGH4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin-protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex which mediates ubiquitination and subsequent degradation of AKIN10. Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling and may target ABI5 for degradation.
Subcellular location: Nucleus {ECO:0000269|PubMed:16844902}.
Interaction partners:
- Light-mediated development protein DET1
- DNA damage-binding protein 1b
- RING-box protein 1a
- DNA damage-binding protein 1a
- Protein DAMAGED DNA-BINDING 2
- E3 ubiquitin-protein ligase COP1
- DDB1- and CUL4-associated factor homolog 1
- DET1- and DDB1-associated protein 1
- Transducin/WD40 repeat-like superfamily protein
- WD repeat-containing protein ATCSA-1
Sequence:
MSLPTKRSTFSAASASDDSSYSSPPMKKAKNDLHHSPQHPNTADKVVGFHMEEDPTPAAANLSRKKATLPQPTKKFVIKLNKAKPTLPTNFEENTWEKLQSAIRAIFLKKKISFDLESLYQAVDNLCLHKLDGKLYDQIEKECEEHISAALQSLVGQNTDLTVFLSRVEKCWQDFCDQMLMIRSIALTLDRKYVIQNPNVRSLWEMGLQLFRKHLSLAPEVEQRTVKGLLSMIEKERLAEAVNRTLLSHLLKMFTALGIYMESFEKPFLEGTSEFYAAEGMKYMQQSDVPEYLKHVEGRLHEENERCILYIDAVTRKPLITTVERQLLERHILVVLEKGFTTLMDGRRTEDLQRMQTLFSRVNALESLRQALSSYVRKTGQKIVMDEEKDKDMVQSLLDFKASLDIIWEESFYKNESFGNTIKDSFEHLINLRQNRPAELIAKFLDEKLRAGNKGTSEEELESVLEKVLVLFRFIQGKDVFEAFYKKDLAKRLLLGKSASIDAEKSMISKLKTECGSQFTNKLEGMFKDIELSKEINESFKQSSQARTKLPSGIEMSVHVLTTGYWPTYPPMDVKLPHELNVYQDIFKEFYLSKYSGRRLMWQNSLGHCVLKADFSKGKKELAVSLFQAVVLMLFNDAMKLSFEDIKDSTSIEDKELRRTLQSLACGKVRVLQKNPKGRDVEDGDEFEFNDEFAAPLYRIKVNAIQMKETVEENTSTTERVFQDRQYQIDAAIVRIMKTRKVLSHTLLITELFQQLKFPIKPADLKKRIESLIDREYLEREKSNPQIYNYLA
Protein: BcDNA.GH12350 (Sarcoplasmic calcium-binding protein) (O96676)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAFSIVSRGILRTSREILERNMAATVGVLQQNASPPPNTPISHSDCHRLASGGIICGHGAHSLLWHQMPTAVVQAVRQYSKKAGAAKLRREVESDSDSDSDDEFERRRQKMDSKRSERGDSAFWRRKMRTLHRILDVNHDGVVSFDDFSLLAKRFSDLGHLTPEVAAEFNDVIKHTWEEQFGEITPYNLVTAEQFLTDLHHRLNDKKMAKRIGRFLPYLFKAVDFDHTGHLDLEQYKLFFRCLGLTEDDAAVSFAVIDKNGDGQLSLKEFVHLGRQFFLTEDDSKISKMFWGPLVADH
Protein: Homeobox protein HMX1 (Homeobox protein H6) (O70218)
Organism: Mus musculus (Mouse)
Function: DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MPDELTEPGRATPARASSFLIENLLAAEAKGAGRSTQGDGVREEEEEDDDDPEDEDPEQARRRLQRRRQQRAGSGPGGEARARALGLGPRPPPGPGPPFALGCGGTTRWYPRVHGGYGGGLSPDTSDRDSPETGEEMGRAESAWPRCPGPGTVPREVTTQGPATGGEEAAELAEAPAVAAAATGEARGGRRKKTRTVFSRSQVFQLESTFDLKRYLSSAERAGLAASLQLTETQVKIWFQNRRNKWKRQLAAELEAASLSPPGAQRLVRVPVLYHESPPAAAGPALPFPLAPPAPAPPPPLLGFSGALAYPLAAFPAAASVPFLRAQMPGLV
Protein: TIA1 cytotoxic granule associated RNA binding protein (C9JTN7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRQTQSSAPWMGPNYGVQPPQGQNGSMLPNQPSGYRVAGYETQ
Protein: Radical SAM domain protein, putative (Q38F53)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- tRNA
Sequence:
MNKCKQAGRPMLSEQRRETLGSMYSLVGSHSAVKLCRWQKSMMRGMGGCYKWTMYGIESHRCMEATPSMACANKCVFCWRLNTNPTATEWKWQVDNPHDIVEGMLTSHKTLVHEVQGMPGVTAESLEEAKNPKHCALSLVGEPILYPKVNEFLHILHTKGISTFLVNNGQFPEAVENLATVTQLYLSVDAPNKEVMKILDRPVFADYWDRFNQSVLYMNQRRERTVFRLTMIDGFNMSEDNLREYKVLFEVGRPNFIELKRLTPAFSGNDRSILRMKNVPTWEGLKTYAARLCETILDGKEYSVASVHEHSGCILLAQNRFKVDGVWHTWIDFDKFNAMVLDPAVRPRIVADGYLRPTPDWALPDSQSAGFDPAQCRRITPRRQKYMDANEGSAP
Protein: BstYI (Q84AF2)
Organism: Geobacillus stearothermophilus (Bacillus stearothermophilus)
Interaction partners:
Sequence:
MRIVEVYSHLNGLEYIQVHLPHIWEEIQEIIVSIDAEACRTKESKEKTKQGQILYSPVALNEAFKEKLEAKGWKESRTNYYVTADPKLIRETLSLEPEEQKKVIEAAGKEALKSYNQTDFVKDRVAIEVQFGKYSFVAYDLFVKHMAFYVSDKIDVGVEILPMKELSKEMSSGISYYEGELYNVIRQGRGVPAVPLVLIGIAP
Protein: 5'-3' exoribonuclease (EC 3.1.13.-) (A0A8I6A511)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFNIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCALCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFPFDVERSIDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVNIYKNVVHKTGDSFRRRQKEKRKRMKRDQPAFTPSGILTPYALGSRNSPGCQVASNPRQAAYEMRMQSNSSPSISPNTSFASDGSPSPLGGLKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSEFEKGTKPFKPLEQLMGVFPAASGNFLPPTWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEENRRNSLGSDVLFVGKVHPLHDFILELYQTGSTEPVDVPPELCHGIQGKFSLDEEAILPDQTVCSPVPMLRDLTQNTAISINFKDPQFAEDYVFKAIMLPGARKPAAVLKPGDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVIPRGSGTGVYSNTAPPPANYQGNVYRPLLRGQAQIPKLMSNMRPQDNWRGPPPLFQQQRFDRSVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDHRGGRQGYPREGRKYPLPPPSGRYSWN
Protein: Protein SOMBRERO (NAC domain-containing protein 33) (ANAC033) (Q9MA17)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription regulator. Together with BRN1 and BRN2, regulates cellular maturation of root cap. Represses stem cell-like divisions in the root cap daughter cells, and thus promotes daughter cell fate. Inhibits expression of its positive regulator FEZ in a feedback loop for controlled switches in cell division plane. Promotes the expression of genes involved in secondary cell walls (SCW) biosynthesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:19081078}.
Interaction partners:
- Protein trichome birefringence-like 37
- Bifunctional nuclease 1
- AT-hook motif nuclear-localized protein 11
Sequence:
MEIGSSSTVAGGGQLSVPPGFRFHPTEEELLYYYLKKKVSYEPIDLDVIREVDLNKLEPWELKEKCRIGSGPQNEWYFFSHKDKKYPTGTRTNRATAAGFWKATGRDKSIHLNSSKKIGLRKTLVFYTGRAPHGQKTEWIMHEYRLDDSENEIQEDGWVVCRVFKKKNHFRGFHQEQEQDHHHHHQYISTNNDHDHHHHIDSNSNNHSPLILHPLDHHHHHHHIGRQIHMPLHEFANTLSHGSMHLPQLFSPDSAAAAAAAAASAQPFVSPINTTDIECSQNLLRLTSNNNYGGDWSFLDKLLTTGNMNQQQQQQVQNHQAKCFGDLSNNDNNDQADHLGNNNGGSSSSPVNQRFPFHYLGNDANLLKFPK
Protein: Glutamate carrier 1, isoform A (Glutamate carrier 1, isoform B) (SD15982p) (Q9VGF7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- Mitochondrial glutamate carrier 2
Sequence:
MSSSATIATPLPQPQHQQFALLPKIINGGIAGIIGVTCVFPLDLVKTRLQNQQIGPNGERMYNSMFDCFRKTYKAEGYFGMYRGSGVNILLITPEKAIKLTANDYFRHKLTTKDGKLPLTSQMVAGGLAGAFQIIVTTPMELLKIQMQDAGRVAAAAKLAGKTVEKVSATQLASQLIKDKGIFGLYKGIGATGLRDVTFSIIYFPLFATLNDLGPRRNDGSGEAVFWCSFLAGLAAGSTAALAVNPFDVVKTRLQAIKKADGEKEFKGISDCITKTLKHEGPTAFFKGGLCRMIVIAPLFGIAQTVYYLGVAEGLLGYQKK
Protein: Cysteine-rich receptor-like protein kinase 3 (Cysteine-rich RLK3) (EC 2.7.11.-) (Q9CAL2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- F-box protein At1g70590
- Peptide transporter family protein
- Uncharacterized protein At5g19190
- At4g12840
- At5g43870)
- Pentatricopeptide repeat
- Protein involved in starch initiation 1
- Tagatose-6-phosphate ketose/aldose isomerase, putative
- MIF4G domain-containing protein
- Probable diphthine methyl ester synthase
Sequence:
MPILTLLLLILGLFISPSVSDSRGDTVAQICNNRTTTPQQRSLFVTNFLAAMDAVSPLVEAKGYGQVVNGTGNLTVYAYGECIKDLDKKDCDLCFAQIKAKVPRCLPFQKGTRGGQVFSDGCYIRYDDYNFYNETLSLQDRTVCAPKEITGVNRTVFRDNAAELVKNMSVEAVRNGGFYAGFVDRHNVTVHGLAQCWETLNRSGCVECLSKASVRIGSCLVNEEGRVLSAGCYMRFSTQKFYNNSGNSTSDGNGGHNHLGVILAVTSSVVAFVLLVSAAGFLLKKRHAKKQREKKQLGSLFMLANKSNLCFSYENLERATDYFSDKNKLGQGGSGSVYKGVLTNGKTVAVKRLFFNTKQWVDHFFNEVNLISQVDHKNLVKLLGCSITGPESLLVYEYIANQSLHDYLFVRKDVQPLNWAKRFKIILGTAEGMAYLHEESNLRIIHRDIKLSNILLEDDFTPRIADFGLARLFPEDKTHISTAIAGTLGYMAPEYVVRGKLTEKADVYSFGVLMIEVITGKRNNAFVQDAGSILQSVWSLYRTSNVEEAVDPILGDNFNKIEASRLLQIGLLCVQAAFDQRPAMSVVVKMMKGSLEIHTPTQPPFLNPGSVVEMRKMMMTPTTNQSNSSGSRSDYITEGSSFFEPR
Protein: Protein transport protein tip20 (Q9C0W8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Protein transport protein sec20
- Protein transport protein use1
- Protein transport protein sec22
- Conserved oligomeric Golgi complex subunit 1
- DNA repair protein rad50
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 4
- Protein sly1
Sequence:
MMSQQLIDFIDSRTRHPYKSDEVEKFQQEVNELQLPDPNSLPILSEEEKRQAREDAAFRRSSEGLEDAWLDSAIPADPTPIFRDTVELLCVYQSFVKKSASLDTVANFLDFSTDFSTLSTKKDETEIAPDCLHYIAELLFQKKEREVKEKWKNELTEKLKTLFNWPAINPNLKESSKFESFFGFVRSIQSFKDSETGLPLFMQVYITPYVNQFRYHFMSQKQTNVLSKPEWFFEFLLKVFRSNRSFYMLMRDIKFFPGVPPFFTFINLLNNVAKEKLTHIIKYDDYLVHLVHETLQYSVRLEQHFHYTQDPLIIFLFEQNGTYDKWLGLETQLSLTKLEDIKIASDAWELESDQSDDFSSAVPTKMTVRFRDMIETTFSVLQNLPSLDYQFNFWRSVQLKPMMQYVNWLEAFYESHESSSSIHLPGSLQTDKSKFDIAEVERMCKLYSNFKLLMDWLDDIEDEDVYIRIGHKMGSENYAAFYQVKPRLSTLTNGSFRMILRAVSQTLRPLLDNYSDLDTWVIKEQLPGAALLSTSVSAEIVGFQSRLKEIIALLQKLLIGSSQCEAIYQIGTLVESWMIKIVMTHQFSVRGGVQFAMDAMQIVLEFSDYPLLKFERLMSTVELLSLESGENKLIKKLIIEINQKNYDFIDEFFKTKEITLSYEDALGVLYRRVDAWKD