wanglab/gogpt-training-data huggingface dataset:
Protein: Gap junction protein (F6P2X6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}.
Interaction partners:
- Mitogen-activated protein kinase
- Tight junction protein 1a
- Cyclin-dependent kinase 1
- Mitogen-activated protein kinase
Sequence:
MAPSLSGQSCNMKTAVLAGSRAKVELFQVLYFNRPARRDMTEWTLLKRLLDAVHQHSTMIGRLWLTIMVIFRLLIVAVATEDVYTDEQEMFVCNTLQPGCPNVCYDAFAPISQPRFWVFQIITVSTPSLCFIIYTWHNLSKQPEGEQIKEALERSCDSESCSIKSHKHINPSLEGVTNQKPSQASKTSSGVLSKYYIFHVCFRTILEVAFVVAQWLLFGFRVPAHFVCTSSPCMQSVDCYVSRPTEKTVFLIFMFCVGVFCIFLNFLELNHLAWKMIKRSVLVKDGSWNGYGAINQDSQSIASLTFRDVTSTTSLPTLDLVVDHQPDWTCAANCSTKKDNRGTQSKPKTNRKAKQRSTEVWI
Protein: Lysine-specific demethylase JMJ29 (EC 1.14.11.-) (Jumonji domain-containing protein 29) (AtJMJ29) (Protein JUMONJI 29) (Lysine-specific histone demethylase JMJ29) ([histone H3]-trimethyl-L-lysine monodemethylase JMJ29) (C0SV12)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as histone H3 lysine demethylase and be involved in regulation of gene expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Disease resistance protein
- Probable disease resistance protein At1g52660
- Pentatricopeptide repeat-containing protein At1g74600
- Disease resistance protein RPS5
- Probable disease resistance protein At5g47250
- Disease resistance protein RPS2
- PH, RCC1 and FYVE domains-containing protein 1
Sequence:
MDSGVKLEHMNCFQLSYQYSWTTRKKRTLKPFMSKGSSPSSSSDSRKRKLSRAEDSDDSAVKRNAKRRRKICKVEEYYEDDDCILSDWVQRNTAKRIDKRNEEVEVMVKIESGDDCTIGKWFSDVSSKRKDKRQVEVDEDEEWEEEVTLCSKIKATSSRSRTHSLSANSPENVTDVISPCRSRSPASNVSDSIQKNDCTSSRKQSGPICHQCLKGERITLLICSECEKTMFCLQCIRKWYPNLSEDDVVEKCPLCRQNCNCSKCLHLNGLIETSKRELAKSERRHHLQYLITLMLPFLNKLSIFQKLEIEFEATVQGKLPSEVEITAAISYTDERVYCDHCATSIVDLHRSCPKCSYELCLKCCQEIREGSLSERPEMKFHYVDRGHRYMHGLDAAEPSLSSTFEDEEANPSDAKWSLGENGSITCAPEKLGGCGERMLELRRILPLTWMSDLEHKAETFLSSYNISPRMLNCRCSSLETELTRKSASRTTSSDNYLFCPESLGVLKEEELLHFQEHWAKGEPVIVRNALDNTPGLSWEPMVMWRALCENVNSTSSSEMSQVKAIDCLANCEVEINTRQFFEGYSKGRTYENFWPEMLKLKDWPPSDKFEDLLPRHCDEFISALPFQEYSDPRTGILNIATKLPEGFIKPDLGPKTYIAYGIPDELGRGDSVTKLHCDMSDAVNILTHTAEVTLSQEQISSVKALKQKHKLQNKVDKQSTEDCNEKEEEEEEELNMPEISSNENEETGSALWDIFRREDVPKLEEYLRKHCKEFRHTYCSPVTKVYHPIHDQSCYLTLEHKRKLKAEYGIEPWTFVQKLGEAVFIPAGCPHQVRNLKSCTKVAVDFVSPENIHECLRLTEEFRQLPKNHKAREDKLEASLLSL
Protein: Low affinity tryptophan permease (P23173)
Organism: Escherichia coli (strain K12)
Function: Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Tryptophanase
- Tryptophanase operon leader peptide
- Aromatic amino acid transport protein AroP
- Tryptophan biosynthesis protein TrpCF
- Tryptophan synthase alpha chain
Sequence:
MTDQAEKKHSAFWGVMVIAGTVIGGGMFALPVDLAGAWFFWGAFILIIAWFSMLHSGLLLLEANLNYPVGSSFNTITKDLIGNTWNIISGITVAFVLYILTYAYISANGAIISETISMNLGYHANPRIVGICTAIFVASVLWLSSLAASRITSLFLGLKIISFVIVFGSFFFQVDYSILRDATSSTAGTSYFPYIFMALPVCLASFGFHGNIPSLIICYGKRKDKLIKSVVFGSLLALVIYLFWLYCTMGNIPRESFKAIISSGGNVDSLVKSFLGTKQHGIIEFCLLVFSNLAVASSFFGVTLGLFDYLADLFKIDNSHGGRFKTVLLTFLPPALLYLIFPNGFIYGIGGAGLCATIWAVIIPAVLAIKARKKFPNQMFTVWGGNLIPAIVILFGITVILCWFGNVFNVLPKFG
Protein: TBC1 domain family member 22A (Q8WUA7)
Organism: Homo sapiens (Human)
Function: May act as a GTPase-activating protein for Rab family protein(s).
Interaction partners:
- Golgi resident protein GCP60
Sequence:
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK
Protein: Putative pentatricopeptide repeat-containing protein At1g56570 (Q9FXA9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquinol oxidase 1a, mitochondrial
Sequence:
MSITKLARSNAFKPIPNFVRSSLRNAGVESSQNTEYPPYKPKKHHILATNLIVSYFEKGLVEEARSLFDEMPDRDVVAWTAMITGYASSNYNARAWECFHEMVKQGTSPNEFTLSSVLKSCRNMKVLAYGALVHGVVVKLGMEGSLYVDNAMMNMYATCSVTMEAACLIFRDIKVKNDVTWTTLITGFTHLGDGIGGLKMYKQMLLENAEVTPYCITIAVRASASIDSVTTGKQIHASVIKRGFQSNLPVMNSILDLYCRCGYLSEAKHYFHEMEDKDLITWNTLISELERSDSSEALLMFQRFESQGFVPNCYTFTSLVAACANIAALNCGQQLHGRIFRRGFNKNVELANALIDMYAKCGNIPDSQRVFGEIVDRRNLVSWTSMMIGYGSHGYGAEAVELFDKMVSSGIRPDRIVFMAVLSACRHAGLVEKGLKYFNVMESEYGINPDRDIYNCVVDLLGRAGKIGEAYELVERMPFKPDESTWGAILGACKAHKHNGLISRLAARKVMELKPKMVGTYVMLSYIYAAEGKWVDFARVRKMMRMMGNKKEAGMSWILVENQVFSFAVSDKMCPNASSVYSVLGLLIEETREAGYVPELDSLVNDQEVGT
Protein: Protein VTE6, chloroplastic (Phytyl-P kinase) (EC 2.7.4.-) (Vitamin E deficient 6) (Q9SYM0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phytyl-phosphate kinase catalyzing the conversion of phytyl-monophosphate to phytyl-diphosphate. Involved in the activation and reutilization of phytol from chlorophyll degradation in plant metabolism, including tocopherol (vitamin E) biosynthesis. Involved in the biosynthesis of phylloquinone (vitamin K), which is required for the photosystem I (PSI) complex stability.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:26452599}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Nuclear/nucleolar GTPase 2
- Polynucleotide 5'-hydroxyl-kinase NOL9
- Pescadillo homolog
- Ribosome biogenesis protein BOP1 homolog
- Chlorophyll synthase, chloroplastic
- ERBB-3 BINDING PROTEIN 1
- Phytol kinase 1, chloroplastic
- Rix1 complex component
- ARM repeat superfamily protein
- ARM repeat superfamily protein
Sequence:
MATISSTLLLNSSRSALPLRFPKFSGFSSSSPFARSYRFGRRNLEPLSNGMLSSGSRADGATAAAASMEGVMTEAMKLIQSASPTWKSAVANNLLIFVLGSPLLVTGLSASGIAAAFLLGTLTWRAYGSAGFLLVAAYFVIGTAATKVKMTQKEAQGVAEKRKGRRGPRSVIGSSAAGCVCAFLSIYQVGGAAFSQLFRLGFVSSFCTKVSDTVSSEIGKAYGKTTYLATTFKIVPRGTEGAMSLEGTLAGLLASFFLASVGCFLGQITPPEAAVCVLASQIANLGESIIGASFQDKEGFKWLNNDVVNVINISLGSIVAILMQQFILQNWVK
Protein: Plant EC metallothionein family protein (F4ILY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTLITDHVCSLSAGDRVDSLLDALSRLRGTLRLKTKMADTGKGSSVAGCNDSCGCPSPCPGGNSCRCRMREASAGDQGHMVCPCGEHCGCNPCNCPKTQTQTSAKGCTCGEGCTCASCAT
Protein: Phosphotransferase (EC 2.7.1.-) (A0A5F9ZHE0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGDRACRGGSETPPARFLGLTQHSPKYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Protein: Sodium/hydrogen exchanger (A9XP97)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004520}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004195}.
Interaction partners:
Sequence:
MAFSTLLLAFLVVSGALHEAAAGLDFYGAEGKQNYSSRSSAEGSASSGNSSHSATITTLPIVTWKWHHVETPYLVALWILTCWICKLVTELNHNITSVIPESGLLIILGFILGGIVWGADKAQTFKLIPVNFFFYLLPQIILDASYCMPNKLFFGNLGAILVHAIIGTCWNAGTVGIALWACYEGGAMGTLNIGCLQFLLFGALMSAVDPVAVIAVFEEVHVNEVLYILVFGESLLNDGVTVVLYNVFDAFVSLGGPKINAAEIIKGIVSFAVVAFGGSFLGVVFAVLTSMLTRVTKNVQIIEAGFIIVLGYLSYLTAEMLSLSAILSLTFCGVCCQKYINANMDEKSVTCLRYSLKVLANGSETMIFVFLGVSAIDQTIWVWNTGFILLTLLFIVVFRMMGVFFLNWILNQSRLIPIDLTDQLVMGYGGLRGAVAYGLAASLDENKIPEKNLMLGTTLIVVYFTVILQGITMKPLVNWLKVKKATQSDLTLNGKLNNRVFEHTLTGMEDICGRMGDNWWTRHWNHFEEKYVCWLLMTSEARKRNDKILDAFHKLNVEDATKYVNEGESKGSLAFIRSYDSASVDFKKKLALEYADIIPDIMADMSEYDFDIDSVPVTSVMKNPIPSVSLDIHEQERRGMSNDLNAHHLLEQHLYKSRRNNRATYSRSHYNTSENPDEMQEIFQRTMGNRLESFKSAKMGVNPAKKVSKHPKKDAPHKPNGKPADPNRDHLYGDEDFEFSADSASSSENTCQFPRRVINTTGAGVDNPAYIPELDTSPSMRNPPWQTETGHNTAVAPSQRAQGRLPWTPTNLRRLAPLRVSSRSTDSFAMPEPAADEETPEEKPATHHTRL
Protein: CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) (Phosphatidylserine synthase) (P9WPG1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Phosphatidylserine decarboxylase proenzyme
- Probable phosphatidylglycerophosphate synthase
- Putative cardiolipin synthase
- Phosphatidylinositol phosphate synthase
- Phosphatidate cytidylyltransferase
- Phosphoserine phosphatase SerB2
- Probable cystathionine beta-synthase Rv1077
- Probable CDP-diacylglycerol pyrophosphatase
- L-threonine dehydratase biosynthetic IlvA
- Serine hydroxymethyltransferase 1
Sequence:
MIGKPRGRRGVNLQILPSAMTVLSICAGLTAIKFALEHQPKAAMALIAAAAILDGLDGRVARILDAQSRMGAEIDSLADAVNFGVTPALVLYVSMLSKWPVGWVVVLLYAVCVVLRLARYNALQDDGTQPAYAHEFFVGMPAPAGAVSMIGLLALKMQFGEGWWTSGWFLSFWVTGTSILLVSGIPMKKMHAVSVPPNYAAALLAVLAICAAAAVLAPYLLIWVIIIAYMCHIPFAVRSQRWLAQHPEVWDDKPKQRRAVRRASRRAHPYRPSMARLGLRKPGRRL
Protein: Dynein axonemal light chain 4 (O96015)
Organism: Homo sapiens (Human)
Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.
Interaction partners:
- Dynein light chain Tctex-type 1
- Four and a half LIM domains protein 5
- Dynein light chain Tctex-type 3
- Dynein light chain 2, cytoplasmic
- Dynein light chain roadblock-type 1
- Dynein axonemal intermediate chain 2
- Dynein axonemal intermediate chain 1
- Homeobox protein Hox-A4
Sequence:
MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVWKCS
Protein: NapB (Q5AU60)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- histone acetyltransferase
- Histone chaperone asf1
- Histone H2A.Z
- Histone H4.1
- Histone H4.2
- Histone H2B
Sequence:
MSNDQQKDLAERISEPVVPPEVAREIGLLEQQFVRAEVEQMRRSIVELRPLYEKRAKIVAHPEVQSNFWVRVLSNASGDVDQYITPADAAILGSALKNLTVERFEVNEKGEGEPRSIRLTFEFHTGEANPFFENEKLVKELYWRKQVFTTASGKKRTWDGLVSEPVRINWKKDMDVTKGLLDATCDLFEAEKKGGSRRELPEFKKLQEKLAEVEALERDEDDENDDEDPLGHPSGESFFNFFGYRGSDVTAEQSAAATKEEQEKFEKLLKGESVEDDEADEDEDVDDDFEEIEAFPAGSELAVALAEDLWPNALKYYAQSFEEHPDDFDMDDDEDEDEDDEDEEEEDSRPRKKAKV
Protein: LD04004p (Q8MR33)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
TLPSDKMPKLILYGLEASPPVRAVKLTLAALEVPYEFVEVNTRAKENFSEEFLKKNPQHTVPTLEDDGHYIWDSHAIIAYLVSKYGKTDSLYPKDLLQRAVVDQRLHFESGVIFANALRSITKPLFAGKQTMIPKERYDAIIEVYDFLEKFLAGNDYVAGNQLTIADFSIISTVSSLEVFVKVDTTKYPRIAAWFKRLQKLPYYEEANGNGARTFESFIREYNFTFASN
Protein: Cytochrome P450 71B6 (EC 1.14.-.-) (O65787)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Indole-3-acetaldehyde oxidase
- Reticulon-like protein B8
- Style cell-cycle inhibitor 1
- Clathrin light chain 3
- Reticulon-like protein B11
Sequence:
MSLFSFPISTELLPWLLLLLIPPLLIFFLLRSPKNLPPGPPRLPILGNIHQLGSLPHRSLRDLSLKYGPVITVYLGSVRTVVVHSPETAEEVLKLHDSECCTRPKLSITKSFFYDGLGLGFTKWGDYYRDVRKLCVLELFSVKRANSFRNIREEELSRLVNSFSDSASSGSSVDLTANLAKFVASFTCRMAFGLSFQGSGMDNETFLELFTEANRVIGKFAAADIFPGFGWILDRISGLDSSRRKSFQDLDTFYQKAIVDHREKKKTEDREDLIDVLLKLQSQETKLGSSRITDTHIRAIIMDLFVAGVDTSVITLDWTMAELSRHPRVMKKVQAEIREHVGDKGIVTYDDLEALVYMKMVIKETWRLHAPSPILIPREAMTNFKIKGYDIYPGTRIHVNAWAIGRNPDVWKDPDEFIPERFVDSNVETKGTSFELLPFGSGRRGCPAMYVGLSTVEYTLANLLYHFDWKATEEVSVEEAPGLTSHRKHPLHLVPVNVINRKL
Protein: Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) (Q7L1W4)
Organism: Homo sapiens (Human)
Function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress. LRRC8A and LRRC8D are required for the uptake of the drug cisplatin. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Mediates the import of the antibiotic blasticidin-S into the cell.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000269|PubMed:32415200}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24782309, ECO:0000305|PubMed:24790029}; Multi-pass membrane protein {ECO:0000269|PubMed:32415200}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029). {ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029}.
Interaction partners:
- Volume-regulated anion channel subunit LRRC8A
- Volume-regulated anion channel subunit LRRC8B
Sequence:
MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDFALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDINIPFANGI
Protein: Checkpoint suppressor 1-like, isoform A (Checkpoint suppressor 1-like, isoform B) (Checkpoint suppressor 1-like, isoform D) (Q9W3Q5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
- Forkhead box K, isoform N
Sequence:
MSTDNPTQLLTTRDLSQLRGHLQSGTVAVPSTTTSVVAAAAATVAAAHGYRTIAPPQQPANNSSTTTSATAASASASAQPPVIPPVISTSNSNMPASASKYVFLQHNHNGGFTAYDGSAATTAAGSTGTVGATSGNIVLLAAAPLEASSGEALVNVRTTEDDGELRSLSWLSDTNLIKGIVTTTAGQAGKRAATVAIKSATGAAGTVGSGAPNGNLCIVSDLIEELPTNLSETSEQESTGGAASGSAPAASTVYSTTTVHKGASGTTTVVEYKASKANQQQQNSPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTYLPTPTRTTMVGHGYMPVVVSSASQPILSPAKQQLPQQIYVTSNGSSPAGGGTIYKAASQALSSPTTSSSSSSNTTTHHPHKKYLREKMHVQMDHSSHVASTVTVVSSPASSNNSSISSSNTGSVSGSGSSTAAVNGGNSPVPKTSSFSTVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESPAVVTTTTLISAGTLPPGYSFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYYATSTTSAGTTTTTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDSLKEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEKAPNMGKGSLWRVEPQQRQNLIQALNRSPFFPNSAVDKISPSLKSPSGGSAYDSLDGGGSGSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYLFPNLSKAFRNIREDTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANGSGGAGSGGVGSNANGASDGINFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVITSSPSEDHTYSAGGNSNADSGSSTPLTNGNALASVAQAVAQGQNNQGGAGSDSNCASSDAAYDSSEENHNITPEEMADRQRHRDGVDALLSLSGSSIVECGSVATTHYHSNGSSGSSHGSPHKRASSHSLEEEHLQQHREQQLQQQQQQQQHHHQQFGSSQAVYTNGSGSKMALLSSAAANVALAQQQQQQIHQDMYSSTAGHNASMYLGGLNSHCLSGGGGVGVAAGMLPQHLSAATGASNKNKVKPLRGLRTKFKRKSAWMR
Protein: Peroxisome assembly protein 12 (Peroxin-12) (Q9VPT5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity).
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:O00623}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- RING-type E3 ubiquitin transferase
- Peroxisomal targeting signal 1 receptor
- Peroxisomal membrane protein PEX13
- Peroxin-19
- Peroxisome biogenesis factor 2
- Peroxisomal biogenesis factor 3
- Peroxin 11
- Peroxisomal ATPase PEX6
- Peroxisomal membrane protein PEX14
- Peroxisomal membrane protein PEX16
Sequence:
MAEAANVRQNLQNVPSIFEISASETLDNLIYPALSKIFDYFGLRLDFKLWGSLRIQEELSPLLTWLLQYLYLRKRASSFGESFYGLQRTVTTTGDLLNRRQQFASATLLTFMPYVERKLRTRITRHEDTSPWEQRLLSAFHAFHAAKAAHTFFYLVKYASNHSPIFRLLGLTLRYPSEPPKEDQWTYVVLKMLEVLAFFLQFVQWWYSNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTPTACSVSGYVFCWKCIVSHMKEHGTCPVTHYPISLDDLVRIYET
Protein: Putative uncharacterized protein YLR269C (O13550)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MKQNLLAVETWYMLILSFRFLFFSRNYNLILCDYLVNTQTVNRVVMAIRSSKRVGKPLFLRYIVMISLKRLPKKCRCGGSPASLPEKYVIMSNKLPYYTNTELDYVIHLDQIDRDL
Protein: Uncharacterized protein (Q384J4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSHPDGSGKAGSSITHAMALHMISKASLLAGHSTQQQNNGSGSVGNFSDTLSNISGFAASAADNSVRNGATVAASVGNHERHGPVWIALLIWLSFILVVIFIIARFVLWCLSSRRAARAGYNEIWDGVGYSGNRSAMAATDGGAPSSTRTSVVGNASRQQFRHSRQKAARRSYGTENPSAEVEV
Protein: Probable short-chain type dehydrogenase/reductase (O07749)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Coenzyme Q-binding protein COQ10 START domain-containing protein
- Putative cytochrome P450 140
- Probable lipoprotein LppE
Sequence:
MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAALRVQLGAERLWARAVDVTDKAALEGALADFCAGNVGGGLDMMWNNAGIGEGGWFEDVPYEAAVRVVDVNFKAVLTGAYAALPYLKKAPGSLMFSTSSSSGTYGMPRIAVYSATKHAVKGLTEALSVEWQRHGVRVADVLPGLIDTAILTSTRQHSDEGPYTISAEQIRAAAPKKGMFRLMPSSSVAEAAWRAYQHPTRLHWYVPRSIRWIDRLKGVSPEFVRRHIAKSLATLEPKRK
Protein: Serine protease inhibitor 27A (Serpin 27A) (Q9V3N1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan-dependent prophenoloxidase 1 (PPO1)-activating cascade in the hemolymph by inhibiting the serine proteases MP1 and Sp7. May be involved in negatively regulating the melanotic encapsulation around eggs of the parasite L. boulardi.
Subcellular location: Secreted {ECO:0000269|PubMed:12408809, ECO:0000269|PubMed:12456640, ECO:0000269|PubMed:14667416}. Note=Secreted into the hemolymph (PubMed:12456640). Detected in the perivitelline fluid of embryos (PubMed:14667416). {ECO:0000269|PubMed:12456640, ECO:0000269|PubMed:14667416}.
Interaction partners:
- Serine protease ea
- tyrosinase
- Protein spaetzle
- Serine protease inhibitor 28Dc
- GH21475p
- Serine protease 7
- Male accessory gland protein
- Serine protease inhibitor 77Ba
- Serine protease Hayan
- Phenoloxidase 2
Sequence:
MTKMGGNLAVMLLSLFLSALATGNGNSIPTTTTPQGVFETRTDKLPGGAASVPSGAGIYDDIDTFVPFRSDSHDPFSWHLLKTVLQNETADKNVIISPFSVKLVLALLAEAAGAGTQTQVELANTQTDIRSQNNVREFYRKTLNSFKKENQLHETLSVRTKLFTDSFIETQQKFTATLKHFYDSEVEALDFTNPEAAADAINAWAANITQGRLQQLVAPDNVRSSVMLLTNLIYFNGLWRRQFATTFQGSFFRSKDDQSRAEFMEQTDYFYYTTSEKLKAQILRLPYKGKNSLFVLLPYALNGIHDLVKNLENDELKSAQWAMEEVKVKVTLPKFHFDYQQNLKETLRSLGVREIFEDSASLPGLTRGADVAGKVKVSNILQKAGINVNEKGTEAYAATVVEIENKFGGSTAIEEFNVNRPFVFFIEEESTGNILFAGKVHSPTTQN
Protein: Isopropylmalate dehydrogenase-like domain-containing protein (G5EB15)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Homoaconitase, mitochondrial
- Aromatic-amino-acid transaminase, hypothetical
- aromatic-amino-acid transaminase
- Isocitrate dehydrogenase subunit 1, mitochondrial
- Saccharopine dehydrogenase [NADP
- homocitrate synthase
Sequence:
MAAARTLRIGLIPGDGIGREVIPAGRRILEALPASLNLKFNFVDLDAGYDCFKRTGTALPDKTVEVLKKECDGALFGAVSSPSTKVAGYSSPIVALRKKLDLFANVRPVKTTAGTSAGKPIDLVIVRENTEDLYVKEESTEETPNGKVARAIKQISERASSRIATIAGEIALRRQNIRDGAAASGLRTKPMVTITHKSNVLSQTDGLFRETARAALAAQKFSSVEVEEQIVDSMVYKLFRQPEYYDVIVAPNLYGDILSDGAAALVGSLGLVPSANVGDNFAIGEPCHGSAPDIEGKNIANPIATLRSVALMLEFLGEEQAAAKIYAAVDGNLDEGKYLSPDMGGKATTTEVLEDVLKRL
Protein: Signal peptidase complex subunit 3 (Microsomal signal peptidase subunit 3) (Q12133)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Signal peptidase complex subunit 2
- Signal peptidase complex catalytic subunit SEC11
- Signal peptidase complex subunit 1
- Kinetochore protein SPC25
Sequence:
MFSFVQRFQNVSNQAFSMGIVMVVFIMASSYYQLINNNAFSVPSNIDNVKTLINVRTSRYFGSQRGKAKENMKIKFDLNTDLTPLFNWNTKQVFVYLTAEYNSTEKITSEVTFWDKIIKSKDDAVIDVNDLRSKYSIWDIEDGKFEGKDLVFKLHWNVQPWVGLLTYGETVGNYTLTVENKNKV
Protein: At5g50645 (Transmembrane protein) (Q9FGP4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSASSFPRSVILTARSDTKGKSVFSWLTDWQNEEKFHHGFFFFFFFLIIQLIIISSGPLLSLSFRLSLPKFLSIDSQKQKKFQFLRTALSIVPQLGDSKSSIIIEVKIRNSQF