wanglab/gogpt-training-data huggingface dataset:
Protein: C2 domain-containing protein (Q38A05)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKDSYRDPNRAKSYASSADAFSSSAQRSCAVGSATWNGSPCDNSPSSTFISSTGRNTGKLHKVGFRKRETTAPRGETHPPRVPRKQTPPTARSRPVPPLALTQTGARTERGHRMDLRVRVEGVKKLLPPNSASKALPSTFIMVQTATGRGKTPVIFNNANPPFNDEFVFTVRDPKLDEITVVLVSHTPSGNKKLGQCVLSPGNLVCGEEKRRWVSIVRHPGTDQARDYAPMLLSMYTEDFGLRCGPSEAKESEFREKLRALLKNNAPRELHRLEWYVGSCVGDYDGAFSQLCSKYRKSKGTPAAFQLVINAVSDLTDGNGSPSACETCCVKIYAGRVKRVTPMALYRSSAVFNEVFNLSLDDPLSSGITLCVCSPRGKIGECVVSLRGIQKGVAKERTNSLVYAAGTGDASLCGTISFTLYSQTFGVENPIEEAEENARRTRLQNYLWNYLRDDLHRLDPILYSITDVDSFMSVWTRTYGPEPRQHLLRLRIKNLRLLTKLKSPEEFTVVLRTGPNAYRTSCVRYSQDFRFCDELVVSVCTPSAAEFTFIVVKTSDVHEVEMGRATVSFADIPQSSVFKRDIIIYEDALQVGSKDFGTLFIEGITNDFGLPSETLTPERREYYRRRVASILSRYKPTEVYRCDYLLGTHSGMEEQLVRRLSEEYGPETGNAHVNIQILAINDFMLSSPCYVKVYVDDVQVLRTKSHRTALNMQFDISLNNSATLQIENPLRSLLRFELMEPRRFLRSRVVGVAELSLVKMVPNEKNVYRLPVFNAERNGEVGTLSVEIESPSLRHDVSAIFDTPREEDDAELFENVMKDVTTLVSKYCPQNLPHVQPMVAKAASLRDVHRELRDKFTPKRVAFTFYVHIDKLDLSNREDIEAYDEGLISVEAYFMNERVVQPMKVSDVSKARASKLFPEIRFDIVHPHSSEPDCSLPILEIVMHKKNYSTFKPLLAVTRHGTAAAAKPLNVQTTEMGRVVLSARALLTECMYSLGEPVTVGLVSSGERAPQGGTVFGDIESCQRAYIGDLTLRVTVPSFETIPRCLQFSSHVTRDFQQDYVRYHADRIFSLYRAHDPWKLREFYYLLFERDVALGKWPRSLHNWLVNCIKLYGPEAPGTYGPPPKLRLGLKEWDQQRVNRTTASTACTSSGYNTARGSSSAFPSNAFSGSARRSRNGDHGQ
Protein: TRAF family member associated NFKB activator (E7EWR8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKTENYEQRIREQQEQLSLQQTIIDKLKSQLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGIARE
Protein: Uncharacterized protein At5g17350 (Uncharacterized protein T10B6_10) (Q9LF49)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 6,7-dimethyl-8-ribityllumazine synthase
- D-ribose-binding periplasmic protein
- HTH-type transcriptional regulator
- Uncharacterized protein At5g66580
- Emb|CAB85509.1
- 6,7-dimethyl-8-ribityllumazine synthase
- At3g10120
- Uncharacterized protein At3g50800
- At1g21010
- Probable protein phosphatase 2C 25
Sequence:
MGNYVSSALSKTSSSSSSAAKVILPDGGVRNIHAPMKAAELMMEIPSFFLVDAKSLKIGRKFCPLAADDDLQIKGCHVYVAFPMTRATSAANASDLARLFVAAKKQRRHRVGSDHSSAAVKHCHNNGRVSPDGEGDDVKVISAGSKLNLEDIEEFSAAEFMHRISVSKSKKPKLETIVEESLS
Protein: RGS domain-containing protein (D1MN65)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MGYMGCWCSNLGRKYSGTVSPQRSVQPEALSYEMVYSWQQSFDTLMSFKSGQKCFAEFLKSEYSDENILFWQACEELKREKNSEKMEEKARIIYEDFISILSPKEVSLDSKVREIVNTNMSRPTQNTFEDAQHQIYQLMARDSYPRFLTSIFYRETLASFGITEMDIGGDEEKEREQRAERARLNVPATAAEGSSKDISMISTAVIAVQYFMQKFIQIARTSSSNSFNSTCDKLTLISDAAYCICQS
Protein: Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22) (Q9H936)
Organism: Homo sapiens (Human)
Function: Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton. Plays a role in the control of glucose-stimulated insulin secretion (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:A0A0G2K5L2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protocadherin-19
- Cyclin-dependent kinase-like 5
- Syntaxin-binding protein 1
- Protocadherin-10
- Bifunctional polynucleotide phosphatase/kinase
- Potassium voltage-gated channel subfamily KQT member 2
- Spectrin alpha chain, non-erythrocytic 1
- Homeobox protein ARX
- Rho guanine nucleotide exchange factor 9
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Sequence:
MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQDPQA
Protein: E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Carboxyl terminus of HSC70-interacting protein) (AtCHIP) (Plant U-box protein 61) (RING-type E3 ubiquitin transferase CHIP) (U-box domain-containing protein 61) (Q9SRS9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has E3 ubiquitin-protein ligase activity and may target misfolded substrates towards proteasomal degradation. Regulates the activity of some serine/threonine-protein phosphatases by E3 ubiquitin-protein ligase activity. Required for responses to biotic and abiotic stresses such as auxin, abscisic acid (ABA), low and high temperature and darkness, probably through the activation of serine/threonine-protein phosphatase and the subsequent modification of the plasma membrane composition. Regulates the chloroplastic Clp proteolytic activity in response to stresses. Ubiquitylates FtsH1, a component of the chloroplast FtsH protease, and affects protein degradation in chloroplasts. Mediates plastid precursor degradation to prevent cytosolic precursor accumulation, together with the molecular chaperone HSC70-4. Mediates ubiquitination of transit peptides and thereby led to their degradation through the ubiquitin-proteasome system.
Interaction partners:
- Heat shock 70 kDa protein 4
- BAG family molecular chaperone regulator 3
- Heat shock 70 kDa protein 17
- ATP-dependent Clp protease proteolytic subunit 4, chloroplastic
- Ubiquitin-conjugating enzyme E2 2
- Heat shock protein 90-5, chloroplastic
- Ubiquitin-conjugating enzyme E2 22
- Fes1C
- Fes1B
- ARM repeat superfamily protein
Sequence:
MVTGVASAMAERLKEDGNNCFKKERFGAAIDAYTEAIALSPNVPAYWTNRALCHMKRKDWTKVEEDCRKAIQLVHNSVKAHYMLGLALLQKKEFTNGVKELQRALDLGRCSNPTGYMVEEIWEELSKAKYMEWELVSAMRSWELNSLKETCEAALNQQRALDMSRTEESSDEAYTAHTERLKALERVFKKAAEEDKPTEVPDYLCCNITLEIFRDPVISPSGVTYERAAILEHLKKVGKFDPITREKIDPANLVPNLAIKEAVAAYLEKHVWAYKMGC
Protein: Late embryogenesis abundant protein 14 (OsLEA14) (Protein WATER STRESS-INDUCED 18) (Q94JF2)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000269|PubMed:18315698}.
Interaction partners:
- Arginase 1, mitochondrial
Sequence:
MASQQERASYHAGETKARAEEKTGRMMGTAQEKAREAKDTASDAAGRAMGRGHGAKEATKEKAYETKDATKEKAYEAKDAASDATGRAMDKGRGAAGATRDKAYDAKDRAADTAQSAADRARDGAGQTGSYIGQTAEAAKQKAAGAAQYAKETAIAGKDKTGAVLQQAGEQVKSVAVGAKDAVMYTLGMSGDNKNNAAAGKDTSTYKPGTGSDYQ
Protein: Cytochrome c oxidase subunit 8, mitochondrial (Cytochrome c oxidase polypeptide VIII) (A0A1D8PHJ3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU368123}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU368123}.
Interaction partners:
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Cytochrome c oxidase subunit Va
- Cytochrome c oxidase subunit
- Cytochrome b-c1 complex subunit 8, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome c oxidase subunit
Sequence:
MFAQSALRPARTLPSRILTRRNFQVSARKFDINTIVYGTAKEGPYENLPFKIKNRKFVPFAVWYWGVLGFFFAFPFLTSWWQLKKSGAFNKTE
Protein: Regulator of Ty1 transposition protein 107 (Establishes silent chromatin protein 4) (P38850)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16569515}. Note=Recruited to chromatin in response to replication fork stalling.
Interaction partners:
- Structure-specific endonuclease subunit SLX4
- E3 ubiquitin-protein ligase substrate receptor MMS22
- DNA replication regulator DPB11
- Cullin-8
- E3 ubiquitin-protein ligase linker protein MMS1
- Structural maintenance of chromosomes protein 6
- DNA repair protein KRE29
- DNA repair protein RAD9
- Structural maintenance of chromosomes protein 5
- ATP-dependent helicase SGS1
Sequence:
MSTSLLFEQLNFLILVAAEAELPIAHSTRKLLMDNSCNNCQIYELYNENLKDVKTDKDWFMNKFGPQTVHFVISNTINFPFYKIVYFDLLIPVVSHTWVQDSVKTKRHLRTNMYSPNPFHLLRDCQVYISKSSFNKCEYILYSDLLHLLGGTLVNYISNRTTHVIVQSPQDPIIATVSKLTFGSFSSSSTNKHTEKPLREWKFVYPIWILYHFKMAKPLKGELATLCELDMQDTSEEQLFAKWEEVIGDKQTSSSQLTLHPNKTLFKNHHFAISPDLNFFTPLYWFLKGFIEDLDGKVTPLSFSDDLKSVYQAFPDIDCYIGHSANSPILEKTKSIKPEIHVGNVSWLFYMFALQKFTPVSQCKLIHQPFHAKLFTSKELTVAYTNYFGSQRFYIQRLVEILGGLSTPELTRKNTHLITKSTIGKKFKVAKKWSLDPQNAIIVTNHMWLEQCYMNNSKLNPKDSRFQNFKLDDNMGWNIGQIGMDHSSLPTPKNLSMVTYDTQSISEKPPPTNDQMDQINDNTNVLSKKDGTPISSFENSIDEKIDKLQKISGEVAVTHSGDLERSFVSRPSRASFPVVDSKKSNLQKKDSNSDISMETEVFCEGHEKREEKEFTKPITEYDAPKKQEIREQSRKKNDIDYKKEEEETELQVQLGQRTKREIKTSKKNEKEKETNECHIEVDQMTNEKQGEESTGKLISTEDVTSKKDTDKFSHLFEGLSDNDDHINDEKPAVNSKYTTPKTSQNITSGVDTPTTAQTQVFMPSSGNSRLAKTQAAKRLHTDIESLNEFQKNFKRKRIDSEEISLSQDVERSNNNKELATKAEKILARFNELPNYDLKAVCTGCFHDGFNEVDIEILNQLGIKIFDNIKETDKLNCIFAPKILRTEKFLKSLSFEPLKFALKPEFIIDLLKQIHSKKDKLSQININLFDYEINGINESIISKTKLPTKVFERANIRCINLVNDIPGGVDTIGSVLKAHGIEKINVLRSKKCTFEDIIPNDVSKQENGGIFKYVLIVTKASQVKKFTKLINDRDKNETILIVEWNWCVESIFHLNVDFTSKKNVLYQKKNN
Protein: Zinc finger protein STAR3 (Protein ALUMINUM RESISTANCE TRANSCRIPTION FACTOR 1) (Protein ART1) (Protein SENSITIVE TO ALUMINUM RHIZOTOXICITY 3) (Q2QX40)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcriptional activator that regulates the expression of genes involved in aluminum (Al) tolerance. Binds to the promoter of STAR1 and regulates transcript expression of STAR1 STAR2 and ART1 required for Al tolerance.
Subcellular location: Nucleus {ECO:0000269|PubMed:19880795}.
Interaction partners:
- Nitrate reductase
- Nitrate reductase 1
- Nitrate reductase
- protein-serine/threonine phosphatase
- Os04g0589400 protein
- Small ribosomal subunit protein uS2c
- Os01g0220300 protein
- Os06g0255200 protein
- Os02g0102400 protein
- Small ribosomal subunit protein mS29
Sequence:
MDRDQMTNTMRDQAANLTSMNPLFYPFMADDALLGMAPPPPQQLLPSVSIQHMDWSPDTMLDNLTFIEEKIRQVKDVIRSMAGRRASSSSAATPEQQLVNADLTCLIVQLISTAGSLLPSLKNSSFLSRTTPPPAAAAGAAQAVSLAAGESSSSARNNETNREDEEEQMGSPDYDELFKVWTNGGAMDECVGAAGDEQDARENPAAAAEEEKYEVLQLEEDEILAPHTHFCGICGKGFKRDANLRMHMRGHGDEYKSAAALAKPPPPPEGEEQPPQPERRYSCPHAGCKRNRMHASFQPLKTILCVKNHYKRSHCEKRHVCGRCGAKRFSVMADLKTHEKHCGRDRWLCSCGTSFSRKDKLFAHVALFQGHAPALPPPPPPPTSGRRRHKQEEPEFTWGGGGGNEFLDVKGIAGVGSGSGGGDEFFSAGSFGAMDFGFGQLDASLAMLLPSEQFAGDHQEENGDK
Protein: 4-hydroxy-tetrahydrodipicolinate reductase 1, chloroplastic (HTPA reductase 1) (EC 1.17.1.8) (O80574)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- 4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic
- 4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic
- LL-diaminopimelate aminotransferase, chloroplastic
- Aminotransferase ALD1, chloroplastic
- 4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic
- Diaminopimelate epimerase, chloroplastic
- Diaminopimelate decarboxylase 2, chloroplastic
- Acetolactate synthase small subunit 2, chloroplastic
- Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic
- Chorismate synthase, chloroplastic
Sequence:
MATNGLMASSSVFLHRPRIAFASRTNQTVGKYGKGRVSFMGIGTRRLPVVLSMTAMADSGEEAVKSVLPGNGISIMVNGCSGKMGKAVIKAADSAGVNIVPISFGSAGEDGQRVEVCGKEITVHGPTEREKVLSSVFEKHPELIVVDYTIPSAVNDNAELYSKVGVPFVMGTTGGDRNKLYETVEEAKIYAVISPQMGKQVVAFLAAMEIMAEQFPGAFSGYSLDVMESHQASKLDASGTAKAVISCFQELGVSYDMDQIQLIRDPKQQVEMVGVPEEHISGHAFHLYHLTSPDETVSFEFQHNVCGRSIYAEGTVDAVLFLAKKIRLKADQRIYNMIDVLREGNMR
Protein: Actin-depolymerizing factor 5 (ADF-5) (AtADF5) (Q9ZNT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9ZSK3}.
Interaction partners:
- Profilin-4
- Profilin-5
- Profilin-2
- Profilin-3
- Profilin-1
- Cyclase-associated protein 1
- Villin-5
- Villin-1
- Fimbrin-5
- Protein phosphatase EYA
Sequence:
MAMAFKMATTGMRVTDECTSSFMDMKWKKVHRYIVFKIEEKSRKVTVDKVGGAGESYHDLEDSLPVDDCRYAVFDFDFVTVDNCRKSKIFFIAWSPEASKIRAKILYATSKDGLRRVLEGIHYELQATDPTEMGFDIIQDRAK
Protein: Protein ERP1 (Q05359)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in vesicular protein trafficking.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10713261}; Single-pass type I membrane protein {ECO:0000269|PubMed:10713261}.
Interaction partners:
- Endoplasmic reticulum vesicle protein 25
- Protein ERP6
- Endosomal protein P24B
- Protein ERP2
- Protein ERP4
- ER-derived vesicles protein ERV29
- Protein ERP3
- ER-derived vesicles protein ERV14
- ER-derived vesicles protein ERV41
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1
Sequence:
MLLTSLLQVFACCLVLPAQVTAFYYYTSGAERKCFHKELSKGTLFQATYKAQIYDDQLQNYRDAGAQDFGVLIDIEETFDDNHLVVHQKGSASGDLTFLASDSGEHKICIQPEAGGWLIKAKTKIDVEFQVGSDEKLDSKGKATIDILHAKVNVLNSKIGEIRREQKLMRDREATFRDASEAVNSRAMWWIVIQLIVLAVTCGWQMKHLGKFFVKQKIL
Protein: Envelope glycoprotein B (gB) (P06437)
Organism: Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
Function: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).
Subcellular location: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04032}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04032}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04032}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04032}. Host endosome membrane {ECO:0000255|HAMAP-Rule:MF_04032}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04032}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-Rule:MF_04032}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04032}. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). {ECO:0000255|HAMAP-Rule:MF_04032}.
Interaction partners:
Sequence:
MHQGAPSWGRRWFVVWALLGLTLGVLVASAAPTSPGTPGVAAATQAANGGPATPAPPPLGAAPTGDPKPKKNKKPKNPTPPRPAGDNATVAAGHATLREHLRDIKAENTDANFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKYVRNNLETTAFHRDDHETDMELKPANAATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTTYAADRFKQVDGFYARDLTTKARATAPTTRNLLTTPKFTVAWDWVPKRPSVCTMTKWQEVDEMLRSEYGGSFRFSSDAISTTFTTNLTEYPLSRVDLGDCIGKDARDAMDRIFARRYNATHIKVGQPQYYQANGGFLIAYQPLLSNTLAELYVREHLREQSRKPPNPTPPPPGASANASVERIKTTSSIEFARLQFTYNHIQRHVNDMLGRVAIAWCELQNHELTLWNEARKLNPNAIASVTVGRRVSARMLGDVMAVSTCVPVAADNVIVQNSMRISSRPGACYSRPLVSFRYEDQGPLVEGQLGENNELRLTRDAIEPCTVGHRRYFTFGGGYVYFEEYAYSHQLSRADITTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVIHADANAAMFAGLGAFFEGMGDLGRAVGKVVMGIVGGVVSAVSGVSSFMSNPFGALAVGLLVLAGLAAAFFAFRYVMRLQSNPMKALYPLTTKELKNPTNPDASGEGEEGGDFDEAKLAEAREMIRYMALVSAMERTEHKAKKKGTSALLSAKVTDMVMRKRRNTNYTQVPNKDGDADEDDL
Protein: Antifreeze protein type IV (Type-4 ice-structuring protein LS-12 precursor) (E9QGU7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Antifreeze protein type IV
- 40S ribosomal protein S8
- Zinc finger, FYVE domain-containing 9b.
- SplA/ryanodine receptor domain and SOCS box-containing 3b.
- SPRY domain-containing SOCS box protein 3
- SPRY domain-containing SOCS box protein 3
Sequence:
MKLSLITILVVALAIRSESASLVKRDASAELDKIAKYFQDFVDNLKNVEGPELANKANAYLEESRAQFQPMVEKLQEQLKPFSNIEDQIKPIAASVQAQVAPLADIVQTHIEDVLKFVADKTKTILPPQ
Protein: Tectonic-1 (Q8BZ64)
Organism: Mus musculus (Mouse)
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body. Secreted. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Despite the presence of a signal sequence, the full-length protein might not be secreted (PubMed:16357211). {ECO:0000269|PubMed:16357211}.
Interaction partners:
- B9 domain-containing protein 1
- Tectonic-2
- Coiled-coil and C2 domain-containing protein 2A
- Transmembrane protein 216
- B9 domain-containing protein 2
- Transmembrane protein 231
- Meckelin
- Centrosomal protein of 290 kDa
- Tectonic-3
- Jouberin
Sequence:
MGSRGLPPLLLVLLNCYTSSSTQVIAIPAAATPAVTKEDLNSTKATPTTLQPSLSPRTPGTPRAPERSGPRPTPVTDVAALCVCDLLPAQCDVNCCCDPDCSPADFSIFSACSVPVVTGDRQFCSQKAAFYSMNLTADPPHRDFKLIDQINPSVFCIHISNYKPALSFANPEVPDENNFDRLMQTSGGFTLSAESAVPSTAASDGPQPTKYEYGAPLQTAGASSGSFLKLPSPLTSSLCADQNPAAFLVSQAFECSRRVDIEQCEGMEALSMAHYSSPAILRVPNSMTQVSIKIQSVMYRSLNHTLTQLEGHGVLRPSLVSTGQDRLCSNVVLQVKYSLLYTATGQIHEAGLSLVLGTLSSAVSLLQQKFEIHFIQHGTKPVPLSGNPGYRVGLPLAAGFQPQKGSGIIQTTNRQGQFTILRSTSQQDCLASEGLRTPVLFGYNVQSGCQLRLTGTIPCGLLAQKVQDLLRGQAFPDYVAAFGNSRAQDVQDWVPVHFVTYSSNMKGSCQLPVALAIEVKWTKYGSLLNPQARIVNVTAQLVSVPEPLPGPERTVVISTAVTFVDVSAPAEAGFRAPPTINARLPFSFFFPFV
Protein: Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) (Q9HCC9)
Organism: Homo sapiens (Human)
Function: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:19460345}. Early endosome membrane {ECO:0000269|PubMed:19460345}. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated.
Interaction partners:
- Exonuclease mut-7 homolog
Sequence:
MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQDNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL
Protein: Transcriptional regulatory protein QseB (P52076)
Organism: Escherichia coli (strain K12)
Function: Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. Currently it is not known whether this effect is direct or not.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Sensor protein QseC
- Sensor protein BasS
- Sensor histidine kinase GlrK
- Transcriptional regulatory protein GlrR
- Sensor protein PhoQ
- Sensor histidine kinase CpxA
- Sensor histidine kinase HprS
- Sensor histidine kinase CusS
- Protein YgiW
- HTH-type transcriptional activator AaeR
Sequence:
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTARDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLELLMRNAGRVLSRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK
Protein: Serine/threonine-protein kinase polo (EC 2.7.11.21) (P52304)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1660828}.
Interaction partners:
- Kinesin-like protein
- Cell division cycle 14, isoform A
- G2/mitotic-specific cyclin-B
- separase
- FI11703p
- G2/mitotic-specific cyclin-B3
- M-phase inducer phosphatase
- Cell division cycle protein 20 homolog
- G2/mitotic-specific cyclin-A
- Protein aurora borealis
Sequence:
MAAKPEDKSTDIPDRLVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFLKGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTRLESTFLKANLHDAITASAQVCRHSEDYRSDIESLYQQLTNLINGKPRILQGNLGDENTDPAAQPLFWISKWVDYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNIESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLNFSDHMKLILCPRMSAITYMDQEKNFRTYRFSTIVENGVSKDLYQKIRYAQEKLRKMLEKMFT
Protein: Cellulose-binding domain-containing protein (Q54EX0)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Signal transducer and activator of transcription A
Sequence:
MMIKAILLISCIFAFLSMGVISDSNQISMSQNQTSTWDDKNTTFTVWEVMLVNNWNATIIDLTITATANFFSSKPSDIWNVEKVSDKVYHFQPYLIQNGLSTGENFTFGYINEAKTQATFEISNIKTK
Protein: Protein TIFY 3 (OsTIFY3) (Jasmonate ZIM domain-containing protein 1) (OsJAZ1) (OsJAZ10) (Protein EXTRA GLUME 2) (Q7XPM8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Repressor of jasmonate responses negatively regulated by the proteasome in an SCF(COI1) E3 ubiquitin-protein ligase complex-dependent manner. Involved in jasmonate (JA) signaling pathway during spikelet development. Targets directly the transcription activator MYC2 and suppresses the activity of MYC2 in triggering the transcription of MADS1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Transcription factor MYC2
- Coronatine-insensitive protein homolog 1a
- Transcription factor BHLH148
- Coronatine-insensitive protein homolog 1b
- Coronatine-insensitive protein homolog 2
- Os10g0506950 protein
- Protein TIFY 9
- Transcription factor
- Transcription factor
- Protein TIFY
Sequence:
MDLLEKKNIKKGGEVEEEVARKGEERKEEEVVVEEKSHQQQQQQGEEELVGLSLAGGRPKVFPMSSPPPNPSQLTIFYGGSVCVYDSVPPEKAQAIMLIAAAAAAAASATKSNAAIAVKPPVMPAANATQAAVSPVLTRSLSLQSTSVATGQPQVAADPSSICKLQADLPIARRHSLQRFLEKRRDRLVSKAPYPTKSSEGMEASGMEVTAEGKAQ