wanglab/gogpt-training-data huggingface dataset:
Protein: AP-2 complex subunit alpha (Alpha-adaptin) (Clathrin assembly protein complex 2 alpha large chain) (Clathrin assembly protein large alpha chain) (P38065)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Alpha adaptin is a subunit of the plasma membrane adaptor. Facilitates interaction between APL1 and APS2.
Subcellular location: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Interaction partners:
- AP-2 complex subunit mu
- AP-2 complex subunit sigma
- AP-2 complex subunit beta
- Clathrin heavy chain
- AP-1 complex subunit beta-1
- Clathrin light chain
- AP-1 complex subunit sigma-1
- EH domain-containing and endocytosis protein 1
- Epsin-1
- Actin cytoskeleton-regulatory complex protein PAN1
Sequence:
MDRKKTLINSSVSNNNSTIKGLQLFIADLRSAQQAQEQEKRIQSEIVKIKQHFDAAKKKQGNHDRLGGYQRKKYVAKLAYIYITSNTTKLNEILFGLEQTVELLKSSIFSEKFIGYMTLELLYERSEVVAKVNDEVNYQLMKDLSSSDDNFVMLALNFVGVVGELTNRLAYNDDITTGVFKILRSPTSSIYLKKKSALSFLALLKSNHSILTEDLQRKQLWIQRILSLLDDTENYRLTLATIPLIEFIAKYIDPSYCTRLLPQLTEILYNCVVVGTSRSSDNQFPLEYTFANMPNPWLITKVVSLLSILIASPTERDSGSLLQTNNIDNELLNKLRKCVSVAIELGTRQAQDPMERIVQNTVLFSLINFASKLDPSDEAISNSVTALCSLLTSKEINIRYLTLDSLVKLCSSSGKPAIDAVRYKNLDMIFHLLNTERDSSIVRKVVDLLYTFTDVENVKIIVDGLLQYILSPKNLAEPQIKSDIAVKIAILTEKYATDINWFVIISLQLLSLTSNTTINDDEIWQRLCQIVVNNPSLHRITCERLVDYLCKKQASEAIIKAAAFLLGEYSSLITDRISSANLFTLFAEKYFSAPNVAKAMILTTMIKLYKTSPEIGSNVIKFFQLELNSLDIELQTRSFEYLNIIQLAKVNGNTDILQILFEPMPPFNSKSNPLLKRLGSLPASAGSTTLINTPSEASSSTPDLLSKRANSSRSIMVPMPPPSRRNTIDDVNSKISSSEDFSGKDSYYSRQILAPNWREGFTRMISHKQGVLFTSSLMKVFYRITTPDAQQPYVFHISLAFINLTEWEITGLSTQIIPSKTQGNPEYLIMNINTPSTATIGPHKRAEQSYEVSIRKPFDVEDSPILAIHFKCGGSTNTINLKTAIGMTTTLISSDVNPSMHLNLAQFISRWKTLSDALGKEGEYQKSGIKLNKDFRKVETISLEDGLLLLTQTVKRLGFDIVDQTSVRSTLFVSGIIHTKSEGNFGCLMKIQYQVNGTVNVTCKTTTAGPLAKYIVECIKNVLTK
Protein: Membrane-bound acid phosphatase 2 (Q9GNS9)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MPYACLHGGSLCLLISLLSCLGAQAVQTLHLVQLVHRHGARSPKVKHNQSQICGEVPCGYLNAAGKMMLVNAGEFLRNHYNSNASEPFFPEESYNSCVTYSRSTDVPRTLQSAGCLLRGMFPNASEFFPAIHTADVSTDWLLRYDVIPQAYAFSHLDEHWWRNVCNPKLDTLIDTNTLLSVSREVFSEGFCADPQNRCHCAATLFDIGVAMQSDGRIDKHPLLRENLGRLRDIKFFEDSHRFVYNASDRTHAKMGSLGQHLAQEILKNAENHMNGLTSYKLYHYSAHDTTIAPLAATLGDSTTTGITPPYGQLYAFELLYDHEVKGYIIRIRRGAQGQKPEEGYAFSWGEFQMKCMNENHTVYTAEDNKCPYHDFRRFVKSTKPHDPAGLCYLNRRYRELFHCPGNVGKPPNKQCKVFRRVCPAWSCEEGYTLNSVTLECVCSSRKCMENRDLSISTDTLGRNLFTIFIFVLLALLIPIFSVFVCIGKKLRARTRRTRAKG
Protein: Proline-rich protein 19 (B2RW88)
Organism: Mus musculus (Mouse)
Function: Promotes meiotic crossing over formation through its interaction with CNTD1 by participating in the crossover differentiation step of crossover-specific recombination intermediates.
Subcellular location: Nucleus {ECO:0000269|PubMed:32555348}. Chromosome {ECO:0000269|PubMed:32555348}. Note=Co-localized at crossover sites with CNTD1 (PubMed:32555348). Localizes on synapsed chromosome only in mid/late pachytene spermatocytes (PubMed:32555348). {ECO:0000269|PubMed:32555348}.
Interaction partners:
- Transmembrane protein 145
Sequence:
MDPRGPVPQPFQQLQKPGRIRRRKTRRERNKALVSSHRPLARQDPPISSRDPCVILQDPVASAAPKLVVITQGRLSREHRGLFNHEVKSLDVARLLNRGALESHTPQLPTKPSCSPVGVQEPDLQSKGKENKVPGGSGPGPPNSPDLPVLGQLLEELQYQLIVPQAFPRRNLVQESRDTIIRTLQGCHGCVPDLALVLRGCQLPLPEAKPRVPERQRMASSCMEVPEHAPREGKQRTQQATKGCDFAIPHTCNSTTPAHRGSQVQPPGHQLPFLSSASSPSGAAWGPPTAFDMLKSIWLIATPPPPPPQPWDVRPPQPLPQPPSPLLPRTSALDWSPNPPAPLPSLSWVVTQSSPEAWSFPPMRLY
Protein: BPI fold-containing family A member 2 (Parotid secretory protein) (PSP) (Short palate, lung and nasal epithelium carcinoma-associated protein 2) (Q96DR5)
Organism: Homo sapiens (Human)
Function: Has strong antibacterial activity against P. aeruginosa.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- BPI fold-containing family B member 4
- BPI fold-containing family B member 1
- Chondroadherin
- Somatoliberin
- Mitochondrial fission regulator 1
- Peripherin-2
- Carbonic anhydrase 6
- BPI fold-containing family B member 2
- BPI fold-containing family A member 1
- BPI fold-containing family B member 6
Sequence:
MLQLWKLVLLCGVLTGTSESLLDNLGNDLSNVVDKLEPVLHEGLETVDNTLKGILEKLKVDLGVLQKSSAWQLAKQKAQEAEKLLNNVISKLLPTNTDIFGLKISNSLILDVKAEPIDDGKGLNLSFPVTANVTVAGPIIGQIINLKASLDLLTAVTIETDPQTHQPVAVLGECASDPTSISLSLLDKHSQIINKFVNSVINTLKSTVSSLLQKEICPLIRIFIHSLDVNVIQQVVDNPQHKTQLQTLI
Protein: Uncharacterized protein YjiN (P39385)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative dehydratase subunit YjiM
- Uncharacterized protein YjbT
- Uncharacterized protein YdfU
- UPF0509 protein YciZ
Sequence:
MNKLIELRRAKRLALSLLLIAAATFVVTLFLPPNFWVSGVKAIAEAAMVGALADWFAVVALFRRVPIPIISRHTAIIPRNKDRIGENLGQFVQEKFLDTQSLVALIRRHEPALLIGNWFSQPENARRVGQHLLQIMSGFLELTDDARIQRLLKRAVHRAIDKVDLSGTSALMLESMTKNDRHQVLLDTLIAQLIALLQRDKSRKFIAQQIVRWLESEHPLKAKILPTEWLGEHSAELVSDAVNSLLDDISRDRAHQIRHAFDRATFALIDKLKNDPEMAARADAVKSYLKEDEAFNRYLSELWGDLREWLKVDINSEDSRVKERIARAGQWFGETLIADDALRASLNGHLEQAAHRVAPEFSAFLTRHISDTVKSWDARDMSRQIELNIGKDLQFIRVNGTLVGGCIGLILYLLSQLPALFPLGNF
Protein: Serine/threonine-protein phosphatase PP2A (EC 3.1.3.16) (Protein microtubule star) (P23696)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD07294p
- Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit
- Protein phosphatase PP2A 55 kDa regulatory subunit
- Serine/threonine protein phosphatase 2A regulatory subunit
- Connector of kinase to AP-1, isoform E
- AT25231p
- CTTNBP2 N-terminal-like protein
- Uncharacterized protein, isoform B
- MOB kinase activator-like 4
- Cerebral cavernous malformation 3
Sequence:
MEDKATTKDLDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAPRRGEPHVTRRTPDYFL
Protein: Small ribosomal subunit protein uS14A (30S ribosomal protein S14) (P9WH59)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
Interaction partners:
- Large ribosomal subunit protein bL28B
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein bL33A
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein bS18B
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein bS6
- Small ribosomal subunit protein bS16
Sequence:
MAKKSKIVKNQRRAATVARYASRRTALKDIIRSPSSAPEQRSTAQRALARQPRDASPVRLRNRDAIDGRPRGHLRKFGLSRVRVRQLAHDGHLPGVRKASW
Protein: Small ribosomal subunit protein uS2 (J7QM75)
Organism: Escherichia coli
Interaction partners:
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- 30S ribosomal protein S5
- Small ribosomal subunit protein uS8
- Elongation factor Tu
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS11
- 50S ribosomal protein L11
- Alternative ribosome-rescue factor A
Sequence:
MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFEKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEAE
Protein: Serine/threonine protein kinase (A0A1D8PHB0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Ras family GTPase
- Tyrosine-protein phosphatase CDC14
- Oxidant-induced cell-cycle arrest protein 5
- Uncharacterized protein
- Cell cycle protein kinase DBF2
- Mob1p
- Serine/threonine-protein kinase
- Serine/threonine protein kinase
- Mitotic regulator
- Nucleolar protein Dnt1-like N-terminal domain-containing protein
Sequence:
MVLNDFDLKTEALNERTTLHTSQNASSKNGSNKESVLAKYEETNQNDEIEGFENLNDLSFSKYSKFSKASIIVGSDPKSRTTTLDSPFAKKLKEDLNVEFTSDNTKPYYPTVYPIYEFDNNDENSDSPFLDYQNEKGNIPQKLSGQKLRKQQQQQQQQSEAEENFKQSNQYARLQSTPKHQRTSSVKVSLTPAQKFEKRTSTRSHNALDNFELTTLVGNGAFASVYRAVNLKTNQVIAIKQIRIEKDQDVGVLMGEIDLLKILKHRNIVKYHGFVKTATSLNVLLEYCEGGSLRQLYKKLKKGLPEYQIINYVRQILEGLNYLHEQGVVHRDVKAANVLLTDKGDVKLADFGVATKVTSQHLTVVGTPNWMAPETVLGGEGICTASDIWSLGATIIELFTTNPPYHDLNAMATLHAIGTDEHPPLPKNMSTLAKDFLLECFQKQANLRISAKLLLKHKWLNQTATAKTSMATLLRQPSRELRSIKIYSESNDENWDEDFEEIKVSKFQNSTSSIIELKPDNTEKQFKLTEYSKKDLLTLFADEKEDTSGNFEFETIGPNKLAVVAESMDESDPFLNIDIENFDTNELEVQSKMEYLVVRLSRKLEQVHLGYEDAVPALVKVTGRMLHLVKKYPVSHDTLIRDHGVLSLLELLESFQDIPSQQQLWYHCLSILNHVFESDLGTLENFCFLGGIPTVAHFRSATYEVQVRLQVAKFIGILNLSEKALSMFVSCGGLRLVSKFVEEDFDTTPTFPLIAIESIHNILAKDLSRSKSDLCRILSKHGVIFWLVVLLNRLVKYDQKPSIKNVSKEQVEITIERIIDIIKYFSQSETKVRISIGSIDLFKLIFKLFDNLKLSHQLTLLKFVKSMSCISEVLKNLYHAEILEFLVKLLKSYIPSKGNYKEIINVLAPILYNSLALNHRRESEFVNLGGLPYLKTLSIINLPFRQFILPIICEFVHCDASVVNELKKNDIVKIYYNLLLDPYWQSNALDSLHCWYKLEPSYIDLNSPMAVDCLVGGFLLPKVSNLESTLEIYFKLLTNNLPLTRDMSNMNVINSILIKLSLHDKKNPVIQLSYLKVLKCLINYLVDSKSSLPFAKPVVNTLQSLKSRQSSLLIEEVTTELLSVLK
Protein: Transmembrane protein 239 (Q8WW34)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRVGTWICLPGRPGRCRKQHDLGNCPEVPGIFKTLALSPGAPDMMQQPRVETDTIGAGEGPQQAVPWSAWVTRHGWVRWWVSHMPPSWIQWWSTSNWRQPLQRLLWGLEGILYLLLALMLCHALFTTGSHLLSSLWPVVAAVWRHLLPALLLLVLSALPALLFTASFLLLFSTLLSLVGLLTSMTHPGDTQDLDQ
Protein: H-2 class II histocompatibility antigen, A-S alpha chain (P14437)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
EDDIEADHVGVYGTTVYQSPGDIGQYTHEFDGDEWFYVDLDKKETIWMLPEFGQLTSFDPQGGLQNIATGKYTLGILTKRSNSTPATNEAPQATVFPKSPVLLGQPNTLICFVDNIFPPVINITWLRNSKSVTDGVYETSFLVNRDHSFHKLSYLTFIPSDDDIYDCKVEHWGLEEPVLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTIFIIQGLRSGGTSRHPGPL
Protein: Nitrate/nitrite antiporter NarK (Nitrate/nitrite exchanger) (Nitrite extrusion protein 1) (Nitrite facilitator 1) (P10903)
Organism: Escherichia coli (strain K12)
Function: Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. Functions as a nitrate/nitrite exchanger, and protons are unlikely to be co-transported.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23665960, ECO:0000269|PubMed:25959928}; Multi-pass membrane protein {ECO:0000269|PubMed:23665960, ECO:0000269|PubMed:25959928}.
Interaction partners:
- Respiratory nitrate reductase 1 alpha chain
- Respiratory nitrate reductase 1 beta chain
- Respiratory nitrate reductase 1 gamma chain
- Nitrite reductase large subunit
- Nitrate reductase molybdenum cofactor assembly chaperone NarJ
- Respiratory nitrate reductase 2 alpha chain
- Respiratory nitrate reductase 2 beta chain
- Respiratory nitrate reductase 2 gamma chain
- Nitrite reductase small subunit
- Periplasmic nitrate reductase
Sequence:
MSHSSAPERATGAVITDWRPEDPAFWQQRGQRIASRNLWISVPCLLLAFCVWMLFSAVAVNLPKVGFNFTTDQLFMLTALPSVSGALLRVPYSFMVPIFGGRRWTAFSTGILIIPCVWLGFAVQDTSTPYSVFIIISLLCGFAGANFASSMANISFFFPKQKQGGALGLNGGLGNMGVSVMQLVAPLVVSLSIFAVFGSQGVKQPDGTELYLANASWIWVPFLAIFTIAAWFGMNDLATSKASIKEQLPVLKRGHLWIMSLLYLATFGSFIGFSAGFAMLSKTQFPDVQILQYAFFGPFIGALARSAGGALSDRLGGTRVTLVNFILMAIFSGLLFLTLPTDGQGGSFMAFFAVFLALFLTAGLGSGSTFQMISVIFRKLTMDRVKAEGGSDERAMREAATDTAAALGFISAIGAIGGFFIPKAFGSSLALTGSPVGAMKVFLIFYIACVVITWAVYGRHSKK
Protein: Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II) (Palmitoyl-protein hydrolase) (EC 3.1.2.22) (O95372)
Organism: Homo sapiens (Human)
Function: Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity. Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25301951}.
Interaction partners:
- Glycerophosphocholine phosphodiesterase GPCPD1
- Phospholipase B1, membrane-associated
- Phospholipase A and acyltransferase 3
- Patatin-like phospholipase domain-containing protein 6
- Patatin-like phospholipase domain-containing protein 7
- Neuromodulin
Sequence:
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
Protein: Folate synthesis bifunctional protein, mitochondrial [Includes: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) (EC 2.7.6.3) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase); Dihydropteroate synthase (DHPS) (EC 2.5.1.15)] (Q9SZV3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the first two consecutive steps of tetrahydrofolate biosynthesis.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:O04862}.
Interaction partners:
- Dihydroneopterin aldolase 2
- Probable dihydroneopterin aldolase 3
- Dihydroneopterin aldolase 1
- GTP cyclohydrolase 1
- Dihydrofolate synthetase
- Folylpolyglutamate synthase
- D-amino-acid transaminase, chloroplastic
- Folylpolyglutamate synthase
- Folylpolyglutamate synthase
- Aminodeoxychorismate synthase, chloroplastic
Sequence:
MAPLLSQTLIHTGRFLLRRFLEPPPAVISAVAASRVCFHRYYSSKSLSLVSPLGLHCSSLFSPPALCNSAFSSSATSTTIEVQSTEHEVVIALGSNIGNRMNNFREALRLMKRGGICVTRHSCLYETAPVHVTDQPRFLNAAVRGVTKLGPHELLSVLKTIERDMGRKDGIRYGPRPLDLDILFYGKMRISSDKLIIPHERLWERSFVLAPLVDLLGSAVDNDTVAHWHSLAIHPGGIFQAWERLGGESLIGQDGIQRVLPIGDKLWDFSNKTHVMGILNLTPDSFSDGGKFQSIDSAVSRVRSMISEGADIIDIGAQSTRPMASRISSQEELDRLLPVLEAVRGMPEMEEKLISVDTFNSEVASEAISNGADILNDVSAGTLDPNMHKVVAESGVPYMAMHMRGDPCTMQNKENLQYDDVCKDVASELYLRVRDAELSGIPAWRVMIDPGIGFSKSVDHNLDIIMDLPKIREEMAKRSIAVSHAPILVGPSRKRFLGDICGRPEATDRDAATVASVTAGILGGANIIRVHNVRHNADAAKVCDAMLRRRRSKG
Protein: Truncated Kidins220 isoform m1 (A0A076N9K1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
VRAAREQINIGGLAYPPLPLHEAPPRPPSGYSQPASVCSSSASFNGPFPGGVVSPQPHSSYYSGLSGPQHPFYNRPFFAPYLYTPRYYPGGSQHLISRSSVKTSLPRDQNNGLEVIKEDAAEGLPSPTASSREKSWTRKQLMELCDSGFNKQRQASVPATGTSLLLSSMTVDIVCEKLRQIEGLDQGMLPQYCTTIKKANINGRVLAQCNIDELKKEMAMNFGDWHLFRSMVLEMRSVENQVVPEDPRFLNENSSAPVAHGESARRTSHSELPHTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGTGSSTISGRSSPHSTYYIGQSSSGGSIHSNLEQERGKENELKQEEGRKSFLMKRGDVLDYSSSGVSTNEASPLDPITEEDEKSDQSGSKLLPGKKSSERPSLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDKKAEGKAERVAKSPEHSVEPIRTFIKAKEYLSDALLDKKDSSDSGVRSNESSPNHSLHNEAADDSQLEKANLIELEDEGHSGKRGMPHSLSGLQDPVIARMSICSEDKKSPSECSLIASSPEESWPSCQKAYNLNRTPSTVTLNNNTAPTNRANQNFDEIEGVRETSQVILRPGPSPNPTAVQNENLKSMAHKRSQRSSYTRLSKDASELHAASSDSTGFGEERESIL
Protein: Protein SHORT-ROOT (AtSHR) (GRAS family protein 26) (AtGRAS-26) (Protein SHOOT GRAVITROPISM 7) (Q9SZF7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor required for quiescent center cells specification and maintenance of surrounding stem cells, and for the asymmetric cell division involved in radial pattern formation in roots. Essential for both cell division and cell specification. Regulates the radial organization of the shoot axial organs and is required for normal shoot gravitropism. Directly controls the transcription of SCR, and when associated with SCR, of MGP, RLK, TRI, NUC and SCL3.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11565032, ECO:0000269|PubMed:15498493, ECO:0000269|PubMed:25124761}. Nucleus {ECO:0000269|PubMed:11565032, ECO:0000269|PubMed:15498493, ECO:0000269|PubMed:25124761}. Early endosome {ECO:0000269|PubMed:25124761}. Late endosome {ECO:0000269|PubMed:25124761}. Recycling endosome {ECO:0000269|PubMed:25124761}. Note=Cytoplasm and nucleus in the stele (PubMed:11565032, PubMed:15498493). Restricted to the nucleus in adjacent cells (PubMed:11565032, PubMed:15498493). Localization to endosomes promotes the intercellular movement of SHR (PubMed:25124761). {ECO:0000269|PubMed:11565032, ECO:0000269|PubMed:15498493, ECO:0000269|PubMed:25124761}.
Interaction partners:
- Protein SCARECROW
- Zinc finger protein JACKDAW
- Protein PAT1 homolog
- Zinc finger protein MAGPIE
- WUSCHEL-related homeobox 5
- Putative cyclin-D6-1
- Holliday junction resolvase MOC1, chloroplastic
- Catalytics
- Defensin-like protein A
- Thiohydroximate-O-sulfate sulfur/sulfate-lyase
Sequence:
MDTLFRLVSLQQQQQSDSIITNQSSLSRTSTTTTGSPQTAYHYNFPQNDVVEECFNFFMDEEDLSSSSSHHNHHNHNNPNTYYSPFTTPTQYHPATSSTPSSTAAAAALASPYSSSGHHNDPSAFSIPQTPPSFDFSANAKWADSVLLEAARAFSDKDTARAQQILWTLNELSSPYGDTEQKLASYFLQALFNRMTGSGERCYRTMVTAAATEKTCSFESTRKTVLKFQEVSPWATFGHVAANGAILEAVDGEAKIHIVDISSTFCTQWPTLLEALATRSDDTPHLRLTTVVVANKFVNDQTASHRMMKEIGNRMEKFARLMGVPFKFNIIHHVGDLSEFDLNELDVKPDEVLAINCVGAMHGIASRGSPRDAVISSFRRLRPRIVTVVEEEADLVGEEEGGFDDEFLRGFGECLRWFRVCFESWEESFPRTSNERLMLERAAGRAIVDLVACEPSDSTERRETARKWSRRMRNSGFGAVGYSDEVADDVRALLRRYKEGVWSMVQCPDAAGIFLCWRDQPVVWASAWRPT
Protein: Direct IAP-binding protein with low pI (A0A8I5ZR69)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MAALRSWMTRSVTFLFRYGQRFPVSANSKKRCFSELIRPWHKTMLTGFGVTLCAVPIAQKSEPQSLSNEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVSLSEMAAEAAYQTEK
Protein: Protein sat1 (O60183)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Guanine nucleotide exchange factor subunit ric1
- GTP-binding protein ryh1
- Protein argonaute
- Serine/threonine-protein kinase hal4
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein mL46
Sequence:
MTECDVQMYMPVNVVQSGTDFECIVKFTNLRSSEDVNLLLCYASIHGEMYLDYVLVRVTEFDEVQRQGLLNKRTMSGLVHIPKVSSSYSVINTLNGMIGNLFGVKQASTLTEASEQKQENAIPVLLTRPDILGVDITLSPGEEKCFRLKRRIPLRTAPTYKGLAFRFQHALVIGVQSATNNACVEHEFEITIVPNVQQQPELPLGKNSGNRQSSKLFADLSKPIIETDAAEIEEVSAEKARRQFGKNGIRLSQDAQEEEKQKKKYEQHIKKLLDGESNEEGGGEFQDHGMRSEINEEVLEEEDEEKIALLKKLESKQPMATRFEITSKQKVLCRLLLSKSRYRTGEMMMIELEGLDAMVRQVHMQLESVERIVPDIRIRNSVGTERATRKVWCRITRGVFELENMSASMVVPEECPETFETQQFGVEHFLRVELLRAVNKKREMQGPAHPRYSEEVQSPSRSRYSEEVQRVSEGRLSEEVSKEEEKKGGRESGQHKRMASLTNSREMQIQHAPTTFAAETIQCVLPIRIEKRVVWMEDGMEGGMEGMQPV
Protein: Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1) (P46091)
Organism: Homo sapiens (Human)
Function: Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:27716822}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes in presence of its ligand, TAFA1 (By similarity). Internalizes efficiently in response to RARRES2 (PubMed:27716822). {ECO:0000250|UniProtKB:Q8K087, ECO:0000269|PubMed:27716822}.
Interaction partners:
- Retinoic acid receptor responder protein 2
- Glycoprotein hormone alpha-2
- G-protein coupled receptor 22
- Nicotinamide phosphoribosyltransferase
- DBF4-type zinc finger-containing protein 2
Sequence:
MEDLEETLFEEFENYSYDLDYYSLESDLEEKVQLGVVHWVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSGTVSEQLRNSETKNLCLLETAQ
Protein: Large ribosomal subunit protein eL32 (60S ribosomal protein L32) (O94008)
Organism: Candida albicans (Yeast)
Interaction partners:
Sequence:
MATSVPHPKIVKKYTKKFKRHHSDRYHRVAENWRKQKGIDSCVRRRFRGTIPQPNIGYGSNKKTKFLNPAGYKVYLVKNVKDLDVLLLHTKSYAAEIASSVSSRKRVEIVAKAKKLGVKVTNPKGKLNLEA
Protein: Protein inturned (Q9VPH0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Acts downstream of fuz and accumulates asymmetrically in wing cells to regulate planar polarity in the wing. Probably acts by regulating ciliogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10570461}. Cell membrane {ECO:0000269|PubMed:10570461}. Note=Localizes in the vicinity of plasma membrane and the cortical actin cytoskeleton of wing disk and pupal wing cells (PubMed:10570461). Localizes to the proximal side of wing cells, fuz and frtz are required for its localization (PubMed:15556868).
Interaction partners:
- WD repeat-containing and planar cell polarity effector protein fritz
- Protocadherin-like wing polarity protein stan
- Protein prickle
- Mitotic spindle assembly checkpoint protein MAD2A
- Segment polarity protein dishevelled
- Frizzled
- G2/mitotic-specific cyclin-B
- G2/mitotic-specific cyclin-B3
- Diego, isoform A
- Vang-like protein
Sequence:
MRKSPASLPSEAFSSSNSSLSNSYSDGSDLANWEEYVSTDGSLFYMEYVRCEKTGVSAERRVEFMRRSLRLGKKSSRRQPHSNNQNQSQNQNQSHGPSRLDSQTEPQEFRFSQFKTAAPDPKKLDLVITAADRFRFGRRSTAVESILGFRVLPFPDQPECLMVDGFVHDVSALQHGIKRGDWFRSLNGIEVYASNVDELLKQFVEPTQVCLGFQSCGAASAVSPTDPGYNRNVREEQVCKVENFPMFTEKFEQMLITEGNFGIPGSSVDIRMPFAMLLLPPECYQHEQQQDSLYYFPEIPDNFLFKARGSFLTLHAVLSELHTQPLSSRLLVDQVQYHVNYRQLNGFLVLFAYAGGLCCAAECSLRSDELIGYIRFSLPGLVLESFNQEREPGNSSRLKLFLRHFCEIQRTRLVARCHGHIRFEELLGQSRSLPLPKEAQLRIFDALSEMEAMDYRNWNDEPLTTHREFFIYGSALYYDGFLVASLLPPEVRVSVEGFLRCRGIFELLGAAPGIKVREMYVWEEIVLPSATGRYFLTICTKNHLSLAVILKIFDAPDMAPDAVVGPSLFYIEEIQETLDHLVQCGIESLAMFWSVSNKRPEVLDATASESRDQEKEPNNRLESFLKQKLTVLSPSVEEEAQLCSSLGGSSIHSLTPSEDESCRRRLTPIHGTAEDSDSGSDWENFAVQHPLHYGLNLGAESHSQSQMTESMWKEINNVVPVKISAGWKNSVLHYVYIDIANGSLFAPFTDSSENSNYLSEIRQACHIIHAVLQKSKHYRRHLSESSRAQTNSNGHSSHTVSLVKEHGMILEVSTQPKSDGQSQSSTSSRFVVVGRLFQSPAKEVYVCHRSDVPQNIVEMAFRLSFFSMG
Protein: Cadherin 6 (D6RF86)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLGKLVLPASYLPMVRGSHCYCDTLDLSASPIKAYSLI
Protein: Upf3b protein (Q80UI8)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
NDTSLYPHMYARAYINFKNQEDILLFRDRFDGYVFLDNKGQEYHAIVEFAPFQKAAKKKIKKRDTKVGTIEDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKRTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIERIPEREKIRDEPKIKLLRKPEKGDEKELDKRDKTKRLDKENLNEERASGHSYTLPRRSDVELKDEKPKRLDDEGVRDYRDRDRDYERDQERMIRERERLKRQEEERRRQQQKERYEKEKAFKRKEEEMKREKEALRDKGKKSENTESICSLEKIEKKEEVVKRDRIRNKDRPAMQLYQPGARSRSRLCPADDSIKPGDSPVDKKQESGISHRKEGGEE