wanglab/gogpt-training-data huggingface dataset:
Protein: Transcriptional regulatory protein RtcR (P38035)
Organism: Escherichia coli (strain K12)
Function: Transcriptional repressor of the rtcAB genes. Interacts with sigma-54.
Interaction partners:
- RNA 3'-terminal phosphate cyclase
- RNA-splicing ligase RtcB
Sequence:
MRKTVAFGFVGTVLDYAGRGSQRWSKWRPTLCLCQQESLVIDRLELLHDARSRSLFETLKRDIASVSPETEVVSVEIELHNPWDFEEVYACLHDFARGYEFQPEKEDYLIHITTGTHVAQICWFLLAEARYLPARLIQSSPPRKKEQPRGPGEVTIIDLDLSRYNAIASRFAEERQQTLDFLKSGIATRNPHFNRMIEQIEKVAIKSRAPILLNGPTGAGKSFLARRILELKQARHQFSGAFVEVNCATLRGDTAMSTLFGHVKGAFTGARESREGLLRSANGGMLFLDEIGELGADEQAMLLKAIEEKTFYPFGSDRQVSSDFQLIAGTVRDLRQLVAEGKFREDLYARINLWTFTLPGLRQRQEDIEPNLDYEVERHASLTGDSVRFNTEARRAWLAFATSPQATWRGNFRELSASVTRMATFATSGRITLDVVEDEINRLRYNWQESRPSALTALLGAEAENIDLFDRMQLEHVIAICRQAKSLSAAGRQLFDVSRQGKASVNDADRLRKYLARFGLTWEAVQDQHSSS
Protein: Starvation responsive small protein A (B0G168)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in starvation response and aggregation stage of the life cycle. May be involved in fruiting body morphogenesis and spore formation.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Countin-1
Sequence:
MIAKVFKSITPESYILLVNAGLISAYGVRIIFQSVKNDEGKVDEKAHIGIGHFFKKRGAQLVDGKNLTDILKEKKKKKKKKKKINISNKLIIFKISRQLYSKLKLK
Protein: Uncharacterized protein C20orf173 (Q96LM9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLSGPHPSPTFRPNPCPWPCLHSLWMEISPTQLCFLSPGPSPQSPSCCFQGMNSGSELGKLWRKLFKGIPRLSVSHFDFYCGTCVLLGRPQIPQGSSLGNDIDQYPVVFRNASDQGSWMQLEMLLRKLSDLVWTSDALSDKILEDGLVP
Protein: Zinc finger protein 501 (Zinc finger protein 52) (Q96CX3)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation. Essential for Golgi structural integrity.
Subcellular location: Nucleus {ECO:0000269|PubMed:29851555}. Nucleus, nucleolus {ECO:0000269|PubMed:29851555}.
Interaction partners:
- Transcription intermediary factor 1-beta
- Zinc finger-containing ubiquitin peptidase 1
- Polyubiquitin-C
- Ubiquitin carboxyl-terminal hydrolase 5
- Ubiquitin carboxyl-terminal hydrolase 44
- Ubiquitin thioesterase OTU1
- OTU domain-containing protein 7A
Sequence:
MNSSQISLRMKHGRVNMQKKPSKCSECGKFFTQRSSLTQHQRIHRGEKPYVCSECGSCFRKQSNLTQHLRIHTGEKPYKCNECEKAFQTKAILVQHLRIHTGEKPYKCNECGKAFCQSPSLIKHQRIHTGEKPYKCTECGKAFSQSICLTRHQRSHSGDKPFKCNECGKAFNQSACLMQHQRIHSGEKPYTCTECGKAFTQNSSLVEHERTHTGEKLYKCSECEKTFRKQAHLSEHYRIHTGEKPYECVGCGKSFRHSSALLRHQRLHAGE
Protein: Multidrug transporter FLR1 (Drug:H(+) antiporter FLR1) (DHA FLR1) (Flucytosine exporter FLR1) (Q6FRT6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Multidrug transporter that confers resistance to 5-flucytosine (5-FC) and clotrimazole. Confers also resistance to benomyl, but not 4-nitroquinoline-N-oxide, cycloheximide, or fluconazole. Plays direct roles in extrusion of 5-flucytosine and clotrimazole.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28066366}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MNYLHNFKDTLFVDLLEVLNIVTIGEEHVNQLNLSGDASLSASSESSNMSFNSGSEENSQEKSVEDLEKQNCEINIHKNSDKEADTKKDPFLVTFNGEDDPLMPYNWSTNKKALIIIQTMLLTCVNYMGSSIYTPGQLEIQNEFHVGHVVGTLNLSLYVLGYGLGPIVFSPLTEISSIGRLPVYMITFFLFTMLQIGCALAPNFAGLVILRFITGVLCSPALSTGGATLGDIVSQNYLALVLGLWSIGAVAAPVLAPLLGASMVVAKDWRWIFWLLFFCCCATMLLLTFFFPETSSDTVLHRKAARIRKLTGDNRYYTEKEREEAQLPKKQFLIETLYRPFSMMITEPIVLAFDLYIALCYGAFYLFFEAFPIVFGGIYHFTLVEQGLAYFGFCVGCIFAYIILLVFSIKVAAKRFANNTFTPETTLILAMCIGWCIPLALFMFGWTAKVHWILPIISEVFFVLGCFNIFQASFSYLAICYPKYVASVFAGNGFARSSFAAAFPLFGQAMYNNLGTKNYPVAWGSSLVGFFTIGLWVIPFVLYKYGPSLRSMSKYNR
Protein: FAD-binding domain-containing protein (G8BL02)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- Fumarylacetoacetase-like C-terminal domain-containing protein
- Cupin type-2 domain-containing protein
Sequence:
MVSFNVIVCGGGLGGLAAAIGLKKKGHQVTILEGSAALNEVGAGIQMPPNSVKILKEYGIFDKFEKYVTRPNNIILRRYDTGAALSTTPLDPDMTDAYGNPYLLIHRADYQKLLYEAALDLGIEYKNGCRVQKVDQNTATVILETGERYSADLVVGADGIRSRVRDSAVVPEETVLPTPSSNCAFRATVPRAEMLSDPVIAHLMSDVNSNCWIGYRRHVMAYPIRNGEMYNIVMSHPGQATVGKWNEPGNVEEMRNHYKNFDPVVRQLLTHVKSVLKWVLADLPKLPRWVSQSGKVVLIGDAAHAMLPYLAQGAAQAVEDGATLAEELDHCVSTEDIPLALQRYQKKRKRRAETIQAGARKNGDIWHLPDGDEQEERDSLMKARDGHNPDQWSDREFQQWLFGWNAFTSTFESKL
Protein: Trafficking protein particle complex subunit 12 (Uncharacterized protein CGI-87) (Q53QD4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
GDAVKDLMLRFLGEKAAAKRQVLNADSVEQSFVGLKQLISCRNWRAAVDLCGRLLTAHGQGYGKSGLLTSHTTDSLQLWFVRLALLVKLGLFQNAEMEFEPFGNLDQPDLYYEYYPHVYPGRRGSMVPFSMRILHAELQQYLGNPQESLDRLHKVKTVCSKILANLEQGLAEDGGMSSVTQEGRQASIRLWRSRLGRVMYSMANCLLLMKDYVLAVEAYHSVIKYYPEQEPQLLSGIGRISLQIGDIKTAEKYFQDVEKVTQKLDGLQGKIMVLMNSAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYLHESVLFNLTTMYELESSRSMQKKQALLEAVAGKEGDSFNTQCLKLA
Protein: Copper-transporting ATPase, putative (EC 3.6.3.4) (Q4WQF3)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Membrane {ECO:0000256|RuleBase:RU362081}.
Interaction partners:
- Superoxide dismutase 1 copper chaperone
- Iron/copper transporter Atx1, putative
- RNA polymerase I-specific transcription initiation factor RRN6-like protein
Sequence:
MAASDLVRAHDSGPSAGRSPAHMATTTVKVDGMTCGACTSAVEGAFKGLEGVGEVSVSLMMGRAVVHHDPTIISAETIAEKIEDSGFDAEIISTDGPSIQADIPRDAQDAKPRFSTTTLAVEGMTCGACTSAVEGGLKEVRGVKSINVSLLSERAVVEHDASVITPEQLADIIEDRGFGATVLETSTPQDVPRGSLEDADATSRLMNTTVSIDGMTCGACTSSVQSAFDGVDGVVQFNISLLAERAIIVHDPTVLSAQQITTIIEDAGFDATIIASEPKLSTSSSMNSVTLSLHGLRDVVAANDLEDSLLRRPGIYSASINMGTYKLAISFDSAKIGIRTIVEAIEAAGYNALLSESDDTNAQLESLSKTKEVQEWRHAFLFSLSFAVPVFVLNMLLPMYLPKLDFGKLPLCAGVYLGDVLCLLLTIPVQFGIGKRFYVSSYKSLKHRSPTMDVLVMLGTSAAFFYSVFIMLVAMCTMAEKRPRTVFDTSTMLITFITLGRWLENRAKGQTSAALSRLMSLAPSMTTIYDDPIAAEKLAEEWEMTKVCPDEKKPTSSSAAKSGPGHKVIPTELIEIGDIVVLHPGDKVSADGVVIRGESYVDESMITGEALPIYKKKGSTVIAGTVNGTSSIDFKVTRTGKDTQLSQIVKLVQDAQTSRASIQRVADIVAGYFVPAIISLGLITFFGWMFISHVLSHPPQIFVAEGSGGKVMVCLKLCISVIVFACPCALGLSTPTAVMVGTGVGAQQGILVKGGAVLEGATKINHVVFDKTGTLTTGKMTVAEARIERQWLEGRRRLWWLIVGLAEMNSEHPIGKAIVSAAKAESGHSESDGLPGSLGDFNAHVGKGISALIEPAFNGERTRYRAVIGNAAFLRSQGVSVPESVEAEDQLTGSPKPTAGITQIHVAIDHQFAGTIFLRDTVKSTAVATIAALHRMGLKTSLITGDTRSTALSIASVVGIPSEFVHASASPSDKQSIIASMQESGDRVAMVGDGINDSPALATASIGIALASGTDVAMEAADIVLMRPDDLLSVPASLSLSRAVFRRIKLNLMWACLYNVIGLPFAMGLFLPFGGFMLPPMAAGAAMAASSVSVVVSSLLLKFWKRPRWMDAEKLEKAAQLGSAGPYGSRKKWWAAALVSGPGSRPSWLDWARRTGARVWSTVTGRNPRTIDTNDGYVPLQAVEPVV
Protein: SKN-1 Dependent Zygotic transcript (Q93932)
Organism: Caenorhabditis elegans
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase sig-7
- BTB domain-containing protein
- N-acetyltransferase domain-containing protein
- Very Early Transcript
- Malate dehydrogenase
Sequence:
MKLHLLTVLLSLVLLSVNAKPSKEKDFQFSDGNLGTPMEKYFEQMGFEQKERNEQIINKPSSEDESSTATIPNTDHHQLTWIPNDAYLFIGKTRYYFRENWIKLPPIGMKVTEVDSIVQMPEMNHQEVEELRRETEKKEGYVDPKEFEKIHDTIKFSFTMDTFTYYFHKYYTEILLVTAVIVIICIAVGLHHYKKKVEEKDQLHFA
Protein: Diskette (Transcriptional adapter 3) (Transcriptional adaptor 3, isoform A) (Q9VWZ1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSANLKNIKLAHFSGSLGSGGFGISASSGGAGKLPTNGTGGGKSAPTSTFLDSEVLATPGGVVIPIIRTRDVPKLLPTIAAALQRPADDHLAAEDLDAVQLELEQMLSNVALRTRVLKAEYDSLDKDEKRQDRRKLDRVPGSPPCPASMLNGLLGIGSNSSTSLGSPLGGGGASSSSQSKRKRDEPTGVRKKHSSMTILKQQGVSGGTSKHQAKNSPLVVHTDDSMDYLPTLAAANASGSVLPHHQPLPQLPKMTVPKNDTPNKFWLSVEPYCMPLTNEDLRLIDDLLEQYWGPLVPPVPPLGPHYSTVWAQEDIKALQPGGARIKSNNSSGMLKKAEGMVDESITGPLTQRLVSALMEESLMTLPSEQAAVGEHSNSTTSSSNENTHSHSSSSANAAAAAASGNFRSLAMMKHGVGIEQRLKKTLIENGLIDASEFAAHEDVDEVLMEIKRVTTEISTISQFNSEELKRLRAVASEEIKRIAIKQKLDMVDQEILECYKRMLQYRAKRKGHTIEEKQEILRLTNEQRLLADQLERMQMHLPCIGGSGNSLLEPKM
Protein: AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (F8VPQ2)
Organism: Mus musculus (Mouse)
Function: DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor). May function as part of an mSin3A repressor complex (By similarity). Has no intrinsic transcriptional activity. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B. Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305|PubMed:17043311, ECO:0000305|PubMed:23487765}.
Interaction partners:
- Breast cancer metastasis-suppressor 1 homolog
- Histone deacetylase complex subunit SAP30
- Paired amphipathic helix protein Sin3a
- Breast cancer metastasis-suppressor 1-like protein
- Sin3 histone deacetylase corepressor complex component SDS3
- Paired amphipathic helix protein Sin3b
- Histone deacetylase 1
- PHD finger protein 12
- Actin-like protein 6A
- Actin-like protein 6B
Sequence:
MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPLRVGAIVETRTSDGSIQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLTNPEHFGTPVIAKKTNRGRRSSLPITEDEKEEESSEEEDEDKRRLNDELLGKVVSVASTAESTGWYPALVVSPSCNDDVTVKKDQCLVRSFIDSKFYSIARKDIKELDILTLPESELCARPGLRRASVFLKGRIVPDNWKMDISEILESSSSDDEECPAEEHEEEKEKEAKKEEEELPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCGNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTIHHHEPKVKEEKKDFEDSMDEALKEAPEMPLLDVKSEPEENTDSNSESDREDTELKSPRGRRKIVRDANCIKKEIEEEKIEDKFLRDDLENKDAGDDDDDGDPAAKREHELLFGRKSTPKNKEKKIKKPEDSERDSDEEEEKSQEREETESRCDSEGEDEEDDTEPCLTGTKVKVKYGRGKTQKIYEASIKSTEMDDGEILYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKVKNKEDSEKDEKRDEERQKSKRGRPPLKSTFSPNMPYSLSKTSNSEGKSDSCSSDSEADDQLEKSSGGEDLSPDVKEELEKNENAHDDKLDEENPKIVHISKENDRTQAQPSDTLTVEAGDSDQIVHIFGDKVDQVEEFKKQVEKSPKGKGRRSKTKDLSLELIKISPFGQEEAGSEAHGDVHSLEFSSLECKNFSSTEDDIDPYEKEKKLKRKILGQQSPEKKLRLDNGMEMTTGVSQERSDDGAGAEGMKGAHVEQHFETEGEGMPSLTAEPDQGLQELTSEKSDSPAEEEPVHTPLKEEEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVVVEGSESNSLASVPPALPPVAQHNFSVASPLTLSQDESRSIKSESDITIEVDSIAEESQEGLCERESANGFEASVASGACSIIAHERESREKGQKRPSDGNSGLIAKKQKRTPKRTSAAAKTEKNGAGQSSDSEDLPAMDSSSNCTPVKRLTLPKSQKLPRSPARTSPHIKDAEKEKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR
Protein: Spindle pole body component SPC42 (P36094)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane.
Subcellular location: Nucleus {ECO:0000269|PubMed:10339566}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:10339566}.
Interaction partners:
- Spindle pole component 29
- Spindle pole body component 110
- Chaotic nuclear migration protein 67
- Spindle pole body component SPC98
- Gamma tubulin complex adapter SPC72
- Spindle pole body component SPC97
- Spindle pole component BBP1
- Cell division control protein KAR1
- Spindle pole body assembly component MPS3
- NAP1-binding protein
Sequence:
MNGSPTPKRYSSKSSRLYDDYYNIPYQYSNPTPMNRDYNDVGSRINADKLVPEEYKRNTEFINKAVQQNKELNFKLREKQNEIFELKKIAETLRSKLEKYVDITKKLEDQNLNLQIKISDLEKKLSDANSTFKEMRFPKVKDPMVDDDPVSENYDQINVPKHRAPDATGNPRTTNKVSNTSDQDSRLKAIERTLSVLTNYVMRSEDGNNDRMSPLPSPLNTILPINNRLNFQEPKRYNPTVKVNPSDDDIMMYESAELKRVEEEIEELKRKILVRKKHDLRKLSLNNQLQELQSMMDGDDNIKLDNVSKHNHATHRHSSQSSRDYSPSSDACLECSNDLYEKNRVKPENNMSETFATPTPNNR
Protein: NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2) (Q9DBH0)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O00308}.
Interaction partners:
- Neurogenic locus notch homolog protein 3
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Arrestin domain-containing protein 1
- Arrestin domain-containing protein 3
- NEDD4 family-interacting protein 1
- NEDD4 family-interacting protein 2
- DNA-directed RNA polymerase II subunit RPB1
- Ubiquitin-ribosomal protein eS31 fusion protein
- POU domain, class 5, transcription factor 1
- WW domain-binding protein 2
Sequence:
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIVLNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENTQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGSVPNGSAVTDGSQPPSRESSGTAIAPETRHQPPSTNCFGGRSRTHRHSGGSARTATAASEQSPGARNRHRQPVKNSSSSGLANGTVNEEPTPASEPEESSVVGVTSLPAAALSVSSNPNTTSLPAQSTPAEGEEASTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE
Protein: Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P) (P22352)
Organism: Homo sapiens (Human)
Function: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Subcellular location: Secreted.
Interaction partners:
- Glutathione reductase, mitochondrial
- Peroxiredoxin-6
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Glutathione synthetase
- Polyunsaturated fatty acid 5-lipoxygenase
- Phospholipid hydroperoxide glutathione peroxidase GPX4
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Probable glutathione peroxidase 8
- Glutathione peroxidase 7
- Thioredoxin
Sequence:
MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK
Protein: DAB1 (A0A3G6VF52)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSNGYSFEDFEERFAAATPNRNLPTDFDEIFEATKAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQAGS
Protein: STING ER exit protein (STEEP) (Q9H5V9)
Organism: Homo sapiens (Human)
Function: Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport. Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:32690950}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:32690950}; Peripheral membrane protein {ECO:0000269|PubMed:32690950}; Cytoplasmic side {ECO:0000269|PubMed:32690950}. Nucleus {ECO:0000269|PubMed:29374277, ECO:0000269|PubMed:32690950}. Note=Recruited to the endoplasmic reticulum following interaction with phosphorylated STING1. {ECO:0000269|PubMed:37832545}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase-like 1
- Regulator of nonsense transcripts 3B
- Pre-mRNA-processing factor 17
- Serine/arginine repetitive matrix protein 1
- Pre-mRNA-splicing factor SLU7
- THO complex subunit 4
- Pre-mRNA-splicing factor SYF2
- Spliceosome RNA helicase DDX39B
- Developmentally-regulated GTP-binding protein 1
- Progranulin
Sequence:
MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDAAKHAHKFCNTEDEETMYLRRPEGIERQYRKKCAKCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK
Protein: Uricase (EC 1.7.3.3) (Urate oxidase) (Q6DG85)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
Subcellular location: Peroxisome {ECO:0000250|UniProtKB:P09118, ECO:0000255|PIRNR:PIRNR000241}.
Interaction partners:
- 5-hydroxyisourate hydrolase
- 5-hydroxyisourate hydrolase
- Zgc:103559.
- Xanthine dehydrogenase/oxidase
- Transthyretin
- Allantoicase
- 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
- Guanine deaminase
- D-amino-acid oxidase
- D-amino-acid oxidase, tandem duplicate 2.
Sequence:
MATTSNQNVEFVRTGYGKNMVKVLHIRREGNHHHIIELIANVQLTLKTRKDYLTGDNSDIIPTDTVKNTVHALAKLKGIKSIESFALDICEHFLTAFNHVTRVKVNIDEVPWKRLEKNGVEHNHAFIHCPEALRFCEAEQYLSKTPVVHSGLKDMKVLKTTQTGFEGFLRDRFTTLTDAKDRFFCTSVYARWRYNTINVAFDAAWKAVKDTVIQKFAGPYDRGEYSPSVQKTLYDTQLLVLDRIPEVEEIEIIMPNQHYFVIDMTKIGLSNKDEVYLPLDNPSGNITGTVCRKPRARM
Protein: Myosin XIX (A0A087WZQ9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLQQVNGHNPGSDGQAREYLREDLQEFLGGEVLLYKLDDLTRVNPVTLETVLRCLQARYMADTFYTNAGCTLVALNPFKPVPQLYSPELMREYHAAPQPQKLKPHVFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTWTSRCLMKFYAVVATSPASWESH
Protein: G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330 (EC 2.7.11.1) (Q9SXB8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000305|PubMed:17644812}; Single-pass type I membrane protein {ECO:0000305|PubMed:17644812}.
Interaction partners:
- Aspartyl protease AED3
Sequence:
MVVSVTIRRRFVLLLLACTCLLSRRLCFGEDRITFSSPIKDSESETLLCKSGIFRFGFFTPVNSTTRLRYVGIWYEKIPIQTVVWVANKDSPINDTSGVISIYQDGNLAVTDGRNRLVWSTNVSVPVAPNATWVQLMDSGNLMLQDNRNNGEILWESFKHPYDSFMPRMTLGTDGRTGGNLKLTSWTSHDDPSTGNYTAGIAPFTFPELLIWKNNVPTWRSGPWNGQVFIGLPNMDSLLFLDGFNLNSDNQGTISMSYANDSFMYHFNLDPEGIIYQKDWSTSMRTWRIGVKFPYTDCDAYGRCGRFGSCHAGENPPCKCVKGFVPKNNTEWNGGNWSNGCMRKAPLQCERQRNVSNGGGGGKADGFLKLQKMKVPISAERSEASEQVCPKVCLDNCSCTAYAYDRGIGCMLWSGDLVDMQSFLGSGIDLFIRVAHSELKTHSNLAVMIAAPVIGVMLIAAVCVLLACRKYKKRPAPAKDRSAELMFKRMEALTSDNESASNQIKLKELPLFEFQVLATSTDSFSLRNKLGQGGFGPVYKGKLPEGQEIAVKRLSRKSGQGLEELMNEVVVISKLQHRNLVKLLGCCIEGEERMLVYEYMPKKSLDAYLFDPMKQKILDWKTRFNIMEGICRGLLYLHRDSRLKIIHRDLKASNILLDENLNPKISDFGLARIFRANEDEANTRRVVGTYGYMSPEYAMEGFFSEKSDVFSLGVIFLEIISGRRNSSSHKEENNLNLLAYAWKLWNDGEAASLADPAVFDKCFEKEIEKCVHIGLLCVQEVANDRPNVSNVIWMLTTENMSLADPKQPAFIVRRGASEAESSDQSSQKVSINDVSLTAVTGR
Protein: Small ribosomal subunit protein uS8B (40S ribosomal protein S15Ab) (Q7KR04)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S15
- Small ribosomal subunit protein uS17
- 40S ribosomal protein S27
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS19A
- 40S ribosomal protein S24
- Small ribosomal subunit protein uS12
Sequence:
MVRMNVLADALKCINNAEKRGKRQVLLRPCSKVIIKFLTVMMKHGYIGEFEIVEDHRAGKIVVNLTGRLNKCGVISPRFDAPINDIEKWTNNLLPSRQFGYVVLTTSGGIMDHEEARRKHLGGKILGFFF
Protein: Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 1 (Protein ORGAN BOUNDARY 2) (Q6NNI3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription regulator that acts as a developmental regulator by promoting cell growth in response to continuous red (cR), far-red (cFR) and blue (cB) light in a phytochrome-dependent manner, at least during seedling development.
Subcellular location: Nucleus {ECO:0000269|PubMed:14871309}.
Interaction partners:
- PX domain-containing protein EREX
- Probable carboxylesterase 11
- ATP-dependent DNA helicase DDM1
- APO protein 1, chloroplastic
Sequence:
MDLISHQPNKNPNSSTQLTPPSSSRYENQKRRDWNTFCQYLRNHRPPLSLPSCSGAHVLEFLRYLDQFGKTKVHHQNCAFFGLPNPPAPCPCPLRQAWGSLDALIGRLRAAYEENGGPPEANPFGSRAVRLFLREVRDFQAKARGVSYEKKRKRVNRQKPQTQPPLQLQQQQQQPQQGQSMMANYSGATV
Protein: Caveolae-associated protein 3 (Cavin-3) (D3T-inducible gene 2 protein) (DIG-2) (Dithiolethione-inducible gene 2 protein) (Protein kinase C delta-binding protein) (Serum deprivation response factor-related gene product that binds to C-kinase) (Q9Z1H9)
Organism: Rattus norvegicus (Rat)
Function: Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). Seems to have an immune potentiation function, especially in the glioma.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q91VJ2}. Membrane, caveola {ECO:0000250|UniProtKB:Q91VJ2}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91VJ2}. Note=Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000250|UniProtKB:Q91VJ2}.
Interaction partners:
- Caveolin-1
- Caveolae-associated protein 1
Sequence:
MGESALEPGPVPGAPAGGPVHAVTVVTLLEKLATMLEALRERQGGLAERQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVGSHADAAQERAVHRAAQVQRLEANHGLLVARGKLHVLLFKEETEIPARAFQKAPELLGPEDQLVLGPEQPEDEVGESSDEEPVESRAQRLRRTGLQKVQSLKRAFSSRKGSEAAQPTPVKPPRLGPVRNSEGPAEGQPAAQPAMEPVLPSALEPEPPQPTKEDPERPVLQIESAA