wanglab/gogpt-training-data huggingface dataset:
Protein: PCI domain-containing protein (Q38AK9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- SAC3/GANP/THP3 conserved domain-containing protein
Sequence:
MEKKRILPISVSLGEVMPAKKGAQQSPLFEVSPRWMQRAAEGIASRNGMLLTDFVVHAEMGEALTIRDMPEHSGIEPAIDQLRQRLLDSVEQAVGETRVPPSGHADDVKERQLFVEVVLRVAITGALVKYYTESYSIKDADDSKGGDDRQERKQWITQLTKDRFALGLLHVFEVFQEVHSMRRTNYQHRQSNTTVGTVGWDTLLLLHFVHRIPCAARDASPGVIDEATGRIVRSWRKLLQSLQVVDPGLSPEFSRRRGALAVCNGLLSILFRRYNVHQCRVLINTIVQAERVTETGGAAGREVLKPAQHMTSEVLTFYYYKGRVALYDHQAREAFAALQQAYQLLPPPGSGNIVQHRNKQRVRFFLTVAGVVSGRMPPEEIQQRDDLIVYIFQPILKAIQRGDPRAFSIAVDAYGPILRRRGVYFILQRAKLLCFLILVARVHATMDACGEDSTRIPLRVLTTMYINIAREGKMIADQDSAARETTERRPKRQRNEDEIDDGLALTDSEMTWWVAKLISTGLLRGYISCEHKVVVLSRQNPFPTLVAGESAAPLQG
Protein: Mitochondrial glycine transporter B (Solute carrier family 25 member 38-B) (P0CAT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03064}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03064}.
Interaction partners:
- Protein transport protein Sec61 subunit gamma
- Transmembrane protein 70
- Caseinolytic mitochondrial matrix peptidase chaperone subunit Xa.
- Threonine aldolase 1
- Mitochondrial import inner membrane translocase subunit Tim10
Sequence:
MEVALAHPALKAFMCGSLSGTCSTLLFQPLDLVKTRLQTLQNNMHPGAPKVGMITVLFNVIRTEKLLGLWKGVSPSFMRCIPGVGIYFSTFYSLKQHYFQEGSPSAGEAVLLGAGARCVAGVAMLPFTVIKTRFESGRYNYISVAGALKSVCQNEGPKALYSGLTATLLRDAPFSGIYVMFYSQAKKALPQEISSSSIAPLVNFGCGVVAGILASLATQPADVIKTHMQVSPALYPKTSDAMRHVYVKHGLSGFFRGAVPRSLRRTLMAAMAWTVYEQLMARMGLKS
Protein: Uncharacterized protein C1442.11c (O94583)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MLIVNRNPKSLVRGYCKKDIVLRNLDGWLFDMITISTIFKLYNQICSLSSTDRKKTSISNKLQQEFCIMDINKVGRNFISLGKIRSSKRRNAILSYQTIISSFPHNHVQKLFQRTQSTNMIYTKLEYFGHSLFFYFTAFTLSFKDRKILMQADVFFRLKLVFKIAFFFTQTTFLNKKENREL
Protein: Candida glabrata strain CBS138 chromosome A complete sequence (Q6FXU2)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome L complete sequence
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit RPN11
- 26S proteasome regulatory subunit RPN8
- Candida glabrata strain CBS138 chromosome I complete sequence
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit RPN1
- Candida glabrata strain CBS138 chromosome F complete sequence
Sequence:
MANVPIAHIQSDFETDYENGGEFYINVDVSPNSVIEYRVHIDAGSATEVSRVDNGLRTICNDSSFTRQSNGSYKFEVNGKIYWFKTPKRLVSTEELGISESLDLISCDASTDKIVIGDSGGDINVYDHEWMSKLSLVGAHVSDVTTVKIFPSNAVLLSGSTDMQLKVWSLEDGSNPRTLKGHSAGITDTIIIERGRNVLSSSLDGSVRLWELGSGKTISKFCRKENTTDGVTSMSLLVGEESTSMSAQVTDRETGDRLEFGTEGKQVFAGHLSGTITVHDLFNKQQILQIPSSFVAPCNTIAQISEHAIVSGYEDGTVATWDIRKPQQYLQKLDFAGNAINKILNWKDKLFLSSGLDNTFEIASDSGNGKIDITSATHLATEEVNNFVIVPSAPSSRLLAVGKWGLCGIYDI
Protein: Thin, isoform F (A0A0B4LG15)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEQFEQLLTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFPTNVTLQRFLELHIEITGELPDPTSGQIMERCGVCSEKAYLSHCAHCEKKICEDCKSAHMDILRREITRFNSQIRRSLHRLQDSLAIIEKNTMSLQTNAISVTEEIDEIYQRITKAIKDRSDQLKGEIDRYLAVELRNLTTLKENLDLEITNITSNCDTVDKYMNETVEWDDCELMDTKEIFLKTVEFLRHFEYENNDYSRRVRFLVSIDPNQLVMNLATFGDLNIAPHSTPSGGSVSSSHLAPPSALQPGLMRSKSDHRLATQFRQQEERSGYNDEPVLGGRKFGERPQRSATQANNDRYGRSGGDYDYENDYDNEGSSGRAGKSSRFRSRFVRSHQNDDSDSEQQQQQRQQELKERKDRVLDSEDVSRGQLSGIIRLSDCSRVVQRLADIGKEKKEKKSDAAAAAQAAVQAAIQAQKAAMQRQQQKNQQNAADEEELARQKRKNAGSSSTGGAATSTSSGGGDTASDQRVAALKNRGGEESDGSSNQAASPVRNSAASTTRAESKPPVSAQVAAVKKTQRSGSSDSSASTESSASSAAAAAVAATSTSATAAAPATSSSNSTSQNAKAPSSSRYSTARDTTAVPEKKPFVSRFLPQHSTASTTNGSADKKKAESSSSSEEETSSESESESEPETKAKSSATSSTTNTKSTPNSAASSTTAASSSTTSGSYRDRLEARRASRDDSSSTAAGRSSYATPSSSGYGSGSGTTGGRTRAVPAPHHTSESEDRYGSGTGSSALPFSIPYISRPSRARYRKRLADV
Protein: Kinesin-like protein (D3ZI07)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Kinesin-like protein
- Kinesin-associated protein 3
- Kinesin light chain 1
- Kinesin light chain
- Kinesin heavy chain isoform 5A
- Kinesin-like protein
- Intraflagellar transport 20
- Nuclear distribution protein nudE-like 1
- Kinesin-like protein KIF17
- Kinesin light chain 3
Sequence:
MSKLKSSESVRVVVRCRPMNGKEKAAAYDKVVDVDVKLGQVSVKNPKGTSHEMPKTFTFDAVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITVECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYTSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLEEKNKIMNRSFFDDEEDHWKLHPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEPRYRAENIMLLELDMPSRTTRDYEGPAISPKVQAALDAALQDEDEIQVDASSFESTANRKAKARPKSGRKSGASSSSSGNPASQFYPQSRGLVPK
Protein: Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1) (Q14982)
Organism: Homo sapiens (Human)
Function: Binds opioids in the presence of acidic lipids; probably involved in cell contact.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Neurotrimin
- Ryanodine receptor 3
Sequence:
MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHFFIKF
Protein: Grifin (DrGRIFIN) (Galectin-related inter-fiber protein) (Q6DGJ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Binds lactose.
Interaction partners:
- Si:ch73-212j7.3.
- WD repeat domain 17
- Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
- Ankyrin repeat domain 33Aa.
- Ankyrin repeat domain 33Ab
- Histone H1
- Histone H1
- Histone H1
- Histone H1
- Histone H1
Sequence:
MTLRFEASCPDGLCPGWSVILKGETPPEASKFEINFLCDRDDRVAFHFNPRFTESDIICNSYMANRWGQEERCNHFPLGVEEPFQIEIYSDNDHFHVYIDKAKVMQYKHRVEDLKTITKLQVVNDVKISSLEITKKLFY
Protein: Dehydrin DHN1 (AmDHN1) (A8CVF3)
Organism: Avicennia marina (Grey mangrove) (Sceura marina)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19398349}. Nucleus {ECO:0000269|PubMed:19398349}.
Interaction partners:
Sequence:
MAEYGDQYGRQTDEYGNPIRQTGEFGATGAYGANQQYGTTGTTVGYGTDQCVTTVTTGAQKTDQYGTPGTTGAYGTDQYGTTGTTGEYGTHGGGIAPGATDAGLAGGGGGHRRLGSSGSSSSEDDGQGGRRKKGIKEKIKEKLPGGGHGDDQTHPTPPGSGGYGYEHGGAAESPEHEEKKGIMDKIKEKLPGGHH
Protein: G patch domain-containing protein 2-like (Q9NWQ4)
Organism: Homo sapiens (Human)
Interaction partners:
- ATP-dependent RNA helicase DHX15
- PIN2/TERF1-interacting telomerase inhibitor 1
- Nucleolar protein 6
- U3 small nucleolar RNA-associated protein 6 homolog
- KRR1 small subunit processome component homolog
- Probable ATP-dependent RNA helicase DDX10
- Nucleolar MIF4G domain-containing protein 1
- ATP-dependent RNA helicase DDX18
- Bystin
- U3 small nucleolar ribonucleoprotein protein IMP3
Sequence:
MDELVHDLASALEQTSEQNKLGELWEEMALSPRQQRRQLRKRRGRKRRSDFTHLAEHTCCYSEASESSLDEATKDCREVAPVTNFSDSDDTMVAKRHPALNAIVKSKQHSWHESDSFTENAPCRPLRRRRKVKRVTSEVAASLQQKLKVSDWSYERGCRFKSAKKQRLSRWKENTPWTSSGHGLCESAENRTFLSKTGRKERMECETDEQKQGSDENMSECETSSVCSSSDTGLFTNDEGRQGDDEQSDWFYEGECVPGFTVPNLLPKWAPDHCSEVERMDSGLDKFSDSTFLLPSRPAQRGYHTRLNRLPGAAARCLRKGRRRLVGKETSINTLGTERISHIISDPRQKEKNKALASDFPHISACAHEFNPLSPLYSLDVLADASHRRCSPAHCSARQANVHWGPPCSRDIKRKRKPVATASLSSPSAVHMDAVEPTTPASQAPKSPSSEWLVRTSAAEKATDATTATFFKMPQEKSPGYS
Protein: Altronate dehydratase (EC 4.2.1.7) (D-altronate hydro-lyase) (P42604)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the dehydration of D-altronate.
Interaction partners:
- Uronate isomerase
- Altronate oxidoreductase
- Mannonate dehydratase
- 2-dehydro-3-deoxygluconokinase
- 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
- Hexuronate transporter
- D-mannonate oxidoreductase
- Starvation-sensing protein RspA
- 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
- Exu regulon transcriptional regulator
Sequence:
MQYIKIHALDNVAVALADLAEGTEVSVDNQTVTLRQDVARGHKFALTDIAKGANVIKYGLPIGYALADIAAGVHVHAHNTRTNLSDLDQYRYQPDFQDLPAQAADREVQIYRRANGDVGVRNELWILPTVGCVNGIARQIQNRFLKETNNAEGTDGVFLFSHTYGCSQLGDDHINTRTMLQNMVRHPNAGAVLVIGLGCENNQVAAFRETLGDIDPERVHFMICQQQDDEIEAGIEHLHQLYNVMRNDKREPGKLSELKFGLECGGSDGLSGITANPMLGRFSDYVIANGGTTVLTEVPEMFGAEQLLMDHCRDEATFEKLVTMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEDKSLGCTQKAGSSVVVDVLRYGERLKTPGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTPYGGFVPTVKIATNSELAAKKKHWIDFDAGQLIHGKAMPQLLEEFIDTIVEFANGKQTCNERNDFRELAIFKSGVTL
Protein: Metal tolerance protein A2 (Q3EAH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVTPKLHLDLSLTKKVSYLFVSRQTLYRLSSSCLASLFLSFDAFLIARSCFFFQMKDHIHEHDHMVQICGEVSSGETSLVGIKKTCGEAPCGFSDAKTSSIEAQERAASMRKLLIAVLLCAIFIVVEVVGGIKANSLAILTDAAHLLSDVAAFAISLFSLWASGWKANPQQSYGFFRIEILGALVSIQMIWLLAGILVYEAIVRLNNGSGEVEGSLMFAVSAVGLLVNIAMAILLGHDHGHGHGHSHDNGHGHSHDHGHGIAATEHHHDSGHDESQLSDVLIEQKKQRNVNIQGAYLHVLGDSIQSVGVMIGGAIIWYKPEWKILDLICTLVFSVIVLGTTIGMLRNILEVLMESTPREIDPTMLEKGVCEIEEVVAVHELHIWAITVGKLLLACHVKIRPEAEADMVLDKIIDYIKREHNISHVTIQIERQ
Protein: Ras association domain-containing protein 6 (Q80UQ2)
Organism: Mus musculus (Mouse)
Function: Involved in the induction of apoptosis. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B.
Interaction partners:
- Serine/threonine-protein kinase 3
- Ras association domain-containing protein 7
- Modulator of apoptosis 1
- Ras association domain-containing protein 10
Sequence:
MTAMDHQFPSWIVVNESTSISREQLNYLLETYNVFYENQKNLHILYGQTEDGQLIVEGMLDIFWGVKRPIQLKIQDEKQISSFDLLNTPETFSSKGRMTRWGEFDDLYRISELDRTHVLASEARHSPEDYLSYHSTLTPYADEEPESPLLYRTMSEAALVRKRMRAPEMYRKDRMGVLSNHRASINGHVYDHETSIFTPTFGSETKVRANSIMRTEEVIKQLLQKFKIENSPRDFALYIIFGTGEQRKLKKTDVPLLQRLLQGPSKSNARIFLMDKDAEEISRDVAPYINFHFSFLESILQRLDEEEKMEIERIMAKFNTERAFILKCLQSKQAAKTETTV
Protein: Histocompatibility 2, class II, locus Mb2 (B7ZNR3)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAALWLLLLVLSLHCMGAGGFVAHVESTCVLDDAGTPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISNILNEQESLIQRLQNGLQDCATHTQPFWDVLTHRTRAPSVRVAQTTPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH
Protein: Meiotically up-regulated protein C8C9.04 (O14273)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis and sporulation.
Interaction partners:
Sequence:
MTTNPDIVKQTKNEIHQVTSRVQEKLDSKSTNAVEQNNNSSQASVTKDNKKKAAKRAKKKAAKKKKQSAAASASSTPVEEAQHAQEEQQEQTILQEPGFTQTIVEKDADQVDEPLEPIASSALGTVEPPTDNKPSASTSTAVPTTEARNTSITEPANSPSSSSSSASTKSTATTQSADYVVAEHFAPQRNDEQLGNSPASITSKPATTSAAQPSSKVEENMAKATSQPITTAEKEIPELKPIEPEAIMISKEINTTHDQAAATTTAAVASASTTATAESHAVADGIMNDNVLESIGENVQQETVFEDASDIPHADVIPHTTTVTVEEESPIALGQGGVTHEATTSARASASGIPGAFEEVQQTVQEDLPHPTAETVEIARFAEQPVRAQQPEQYESSVVQEATETVTDVGKGVSSTVKNEVNVPSTIPTESENPVAVGGTTAEHPVQEAVTAPTETAHDFSKETTTASKRVSKHDKASAEKHKVARKPSSTGQEPTTPSTPAKSAQSSKHARRPSKQASAPSSPGTTSAAVPGGKKSAIEAAAPIPTSADTVESKHAAGSGSATTIPSPGSATTKPTPGSATTKPTPVSATEEHAAGTTKPAPAAGATATAENETADGKAQTATDGEAAPKKSWFKRMKKSFGKLFH
Protein: Large ribosomal subunit protein eL42z/eL42y (60S ribosomal protein L36a) (O23290)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL24z
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein uL24z
- Large ribosomal subunit protein eL21x/eL21w
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL36z
- Large ribosomal subunit protein eL28y
- Large ribosomal subunit protein eL38z/eL38y
- Ubiquitin-ribosomal protein eL40z fusion protein
Sequence:
MVNIPKTKNTYCKNKECKKHTLHKVTQYKKGKDSLAAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKIVLRLQCQSCKHFSQRPIKRCKHFEIGGDKKGKGTSLF
Protein: Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25) (P80188)
Organism: Homo sapiens (Human)
Function: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis.
Subcellular location: Secreted {ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:27780864, ECO:0000269|PubMed:7683678}. Cytoplasmic granule lumen {ECO:0000269|PubMed:8298140}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:12453413}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821). {ECO:0000250|UniProtKB:P11672, ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:20581821}.
Interaction partners:
- Solute carrier family 22 member 17
- Matrix metalloproteinase-9
- Lactotransferrin
- Cytotoxic T-lymphocyte protein 4
- Hepcidin
- Low-density lipoprotein receptor-related protein 2
- Amyloid-beta precursor protein
- Fibronectin
- Cystatin-C
- Hepatitis A virus cellular receptor 1
Sequence:
MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG
Protein: GTPase IMAP family member 3 (Immunity-associated nucleotide 4 protein) (IAN-4) (Q99MI6)
Organism: Mus musculus (Mouse)
Function: During thymocyte development, may support the positive selection of CD4 and CD8 T cells. May play a role in mitochondrial DNA segregation in hematopoietic tissues. Binds GTP.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25808953}; Single-pass type IV membrane protein {ECO:0000269|PubMed:11238997}. Note=The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications. {ECO:0000305|PubMed:11238997, ECO:0000305|PubMed:25808953}.
Interaction partners:
- Apoptosis regulator Bcl-2
- GTPase IMAP family member 4
Sequence:
METLQNVVTGGKKGGCTSGSRPLRILLVGKSGCGKSATGNSLLRRPAFESRLRGQSVTRTSQAETGTWEGRSILVVDTPPIFESKAQNQDMDKDIGDCYLLCAPGPHVLLLVTQLGRFTAEDVMAVRMVKEVFGVGVMRHMIVLFTRKEDLAEKSLEEFVTHTDNRSLRSLVQECGRRYCAFNNRASGEEQQGQLAELMALVRRLEQECEGSFHSNDLFLHAETLLREGYSVHQEAYRCYLAKVRQEVEKQRWELEEQEGSWVLKVLPIGKKLEVLHSDFCWYLVLAILIFFVFFFLLFYV
Protein: Caspase-12 (CASP-12) (EC 3.4.22.-) (O08736)
Organism: Mus musculus (Mouse)
Function: Involved in the activation cascade of caspases responsible for apoptosis execution.
Interaction partners:
- TNF receptor-associated factor 2
- Caspase-1
- Caspase-7
- Calpain-2 catalytic subunit
- Calpain-1 catalytic subunit
- Caspase-3
- Endoplasmic reticulum chaperone BiP
- Apoptosis-associated speck-like protein containing a CARD
- DNA damage-inducible transcript 3 protein
- Cyclic AMP-dependent transcription factor ATF-6 alpha
Sequence:
MAARRTHERDPIYKIKGLAKDMLDGVFDDLVEKNVLNGDELLKIGESASFILNKAENLVENFLEKTDMAGKIFAGHIANSQEQLSLQFSNDEDDGPQKICTPSSPSESKRKVEDDEMEVNAGLAHESHLMLTAPHGLQSSEVQDTLKLCPRDQFCKIKTERAKEIYPVMEKEGRTRLALIICNKKFDYLFDRDNADTDILNMQELLENLGYSVVLKENLTAQEMETELMQFAGRPEHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHDDTIFKIFNNSNCRSLRNKPKILIMQACRGRYNGTIWVSTNKGIATADTDEERVLSCKWNNSITKAHVETDFIAFKSSTPHNISWKVGKTGSLFISKLIDCFKKYCWCYHLEEIFRKVQHSFEVPGELTQMPTIERVSMTRYFYLFPGN
Protein: Potassium channel (Q8IT87)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTVYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLDEEDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGKQGSKAKDVYASKISLASRVVKVERQVADIEEKLDILIKAYMEDRDRFLALLLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSELRSLTATQTPTTTTDAIATQTLMPPHVQHTATNTKYKHPKTCSLHRSTSEPYSKQEQRITIPDEGADSLDSSAKPTPPDSSSN
Protein: Mitochondrial import inner membrane translocase subunit TIM14 (DnaJ homolog subfamily C member 19) (Q9CQV7)
Organism: Mus musculus (Mouse)
Function: Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:24856930}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000269|PubMed:24856930}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import inner membrane translocase subunit TIM50
- Stress-70 protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim23
- Mitochondrial import inner membrane translocase subunit Tim17-A
- Mitochondrial import inner membrane translocase subunit Tim21
- Mitochondrial import inner membrane translocase subunit Tim17-B
- Mitochondrial import inner membrane translocase subunit TIM44
- Prohibitin-2
- Prohibitin 1
Sequence:
MASTVVAVGLTIAAAGFAGRYVLQAMKHVEPQVKQVFQSLPKSAFGGGYYRGGFEPKMTKREAALILGVSPTANKGKIRDAHRRIMLLNHPDKGGSPYIAAKINEAKDLLEGQAKK
Protein: Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 7.1.1.8) (Complex III subunit 7) (A0A1D8PJX3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P08067}; Single-pass membrane protein {ECO:0000250|UniProtKB:P08067}.
Interaction partners:
- Cytochrome c oxidase subunit 3
- 4Fe-4S ferredoxin-type domain-containing protein
- Cytochrome b-c1 complex reductase subunit, mitochondrial
- Cytochrome b-c1 complex subunit 6, mitochondrial
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome b-c1 complex catalytic subunit, mitochondrial
- Cytochrome c oxidase subunit Va
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Cytochrome c oxidase subunit 6, mitochondrial
Sequence:
MSSLAFRTLRNGLGLKSSVRALSTTTTTLSNYQQPDYSSYLNNKSGQGSRNFTYFMVGSMGLLSAAGAKSTVEAFLSSFAASADVLAMAKVEVKLGAIPEGKNVIIKWQGKPVFIRHRTADEIEEANQVDIKTLRDPQNDADRVKKPEWLIMLGICTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPEYDFTDDETLLVG
Protein: Membrane-associated phosphatidylinositol transfer protein 3 (PITPNM family member 3) (E7F006)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
- Cytoplasmic phosphatidylinositol transfer protein 1b
- Phosphatidylinositol transfer protein beta isoform
- Phosphatidylinositol transfer protein beta isoform
- Phosphatidylinositol transfer protein alpha isoform
- Phosphatidylinositol transfer protein, alpha b.
- rRNA methyltransferase 3A, mitochondrial
Sequence:
MAKETRGKANLRKHSASHWRMQNIAQESVDSSDDEFFDAREVLEGKTAMLLGMSQWNSNDLVEQIETMGHIDQTQESLYRVRRTKCIPQTSIDGLEEAEKCQTHVLVLVVHGGNILDPAGGEPGAKTTDVNTLSSVLEKVSQAHFQAAAQHVVIKLVPCPAVCAEAFCLVSNLNPYSYDESCVSSSVDHLPLAALPLLAIAAPHYQDAVATVIARANQVYHRFLQSPEGQGFTGQVCLLGDCVGGVLCFDALCFSNSPRHSSPIHSSRHNSTESLKDNPDVSPSLSSSKRLSRSNIDLSAPSETRNRKTPLSRKQSDSYDGDSGGQHHPFLSSLIQDGADLRPNSSTSLVLNPGRFDFEVSDCFLLGCPLGLVLAMRRTVLPAVQVSQLRPACSQIFNLFYPSDPSASRLEPLLHSQFHKLPPFPVPRYQRYPLGDGRSNLIADEIPSYPDAFLPGSVVPVGVLQPSSPQTERTAGVRVGGEVRRSSLTSMDSQSSGCLESRLSSTIANISSSWWGSKRLDYALYCPDVLTSFPTVALPHLFHASYWESTDVVAFLLRQVMHCDYVKAQEMDNCDSAPFSPSSPREKWLRRRTHVKLRNVTANHRVNDVIATEDGHQTLVGRFMYGPLDMVTLTGEKVDVYVMTQPQSSRWVHLDTEVTNSSGRVTYTIPKSKKLAVGVYPIKMVVKGDQTSGEAFLTVLPRGMECVVFSIDGSFAASVSIMGSDPKVRPGAVDVVRHWQDLGYLIIYITGRPDMQKQRVVSWLSQHNFPQGMIFFSEGLVHDPLRQKTIFLRNLMQECHIKINCAYGSMKDISVYSILGLSPNQIYIVGRPSKKYQNQCQFLSEGYAVHLSSLQFSHRARPKKSSSVRMVLRKGSFGLSAKPDFLCKRTHLRRTMSVQQPDPPMTPNPKPERAQSQPETDKDHGGGGGPSHALWARGSMHRGDTTP
Protein: Trehalose-phosphatase (EC 3.1.3.12) (Trehalose-6-phosphate phosphatase) (ZrTPS2) (Q9P4D3)
Organism: Zygosaccharomyces rouxii
Function: Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process.
Interaction partners:
Sequence:
MVNSGHRRQRIINCVAQLPYKIQLGETNDEWNIVPATGSSSLYSSIEYLNSEEKAKDYEQHVLGWTGEIGRESLPSRLFNSKNRDKSENGEKGENDLHAKEEREKEEDPLYLTNDQIDGITKDLRRHGKSDDHYNVDNVHPVWLLRRDQKRWRGFAENVLWPTFHYILKFSSDSGEKENLSWYDYVRFNEAYAMKIGEIYEKGDIIWIHDYYLLLLPQLLRMKFNDQDLTIAYFHHSPWPSNEYFRVLPRRKQILDGLMGADRGWFQNEGFARHFVSSCKRLLDSTSRKSKNRLGMEQYQISAYGGDIVVDSLPIGINRVKLLEDTFTKDIAQKVLAIKDAFQGKKIIVGRDRLDSVRGVVQKLRAFETFLSMYPEWRDQVVLIQVSVPSMKGGTNQLIRLEQQVNELVTSINMQYGSLNFSPVHHYYMRIPKDVYLSLLRVADLCVIASVRDGTNTTALEYVTVKSHMSNYNCYGNPLILSEFSGTSTILKDAMIINPWDSVAVAKSINRALSLSRDEKRALEDKIWPQVPTIQKWTDQFLSTLSDIVDEAHNTTDRKMTPALNRPALLEHYRQSKRRLFLFDYDGTLTPIVQDPAAAIPSARLISILQKLASDPCNQIWIISGRDQAFLNKWLGSRLPQLGLSAEHGCFYKDVDEENWINLTEKFDMSWQEKVGSIMEEFTRRTPGSFIERKKVALTWHYRRADPELGEFYASELKKELDKICADYDLDVMEGKANIEVRPKFVNKGEIVKRLVWHHHGRRQDMLNTKKEELPISEMPDFTLCLGDDFTDEDMFNQLNDIEAVWKKQYEDEVNQWGGFGLYPCTVGSASKKTVAKAHLTDPQQVLDTLGLLVGDVSLFQSAGTVELDSRGHVKHSDSSIRSEQASARYAMKRQQSYKN