wanglab/gogpt-training-data huggingface dataset:
Protein: Dauer larva development regulatory growth factor daf-7 (Abnormal dauer formation protein 7) (P92172)
Organism: Caenorhabditis elegans
Function: Under harsh environmental conditions, larvae enter a developmentally arrested state known as dauer; TGF-beta-like daf-7 acts to inhibit dauer larva formation and promote growth. May be a ligand to cell surface receptor daf-4. May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. Involved in sensitivity to CO2 levels. Involved in mate searching behavior of males, acting in concert with the neuropeptide pdf-1. In AWC neurons, acts to promote expression of srsx-3, a member of the GPCR family.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Cell surface receptor daf-4
- Cell surface receptor daf-1
- Insulin-like receptor
- Smad protein daf-8
- Dwarfin sma.
- Smad-related protein daf-14
- Ski protein homolog
- Receptor-type guanylate cyclase daf-11
- Forkhead box protein O
- Uncharacterized protein
Sequence:
MFMASSLPVFIFLLSLPHGLTFNCTNSGVCIEKMKQHRTEYLKNEILDQLNMKEAPKGLKPMDPEMKSVYLEMYRDLLEKDEQDMGVEMSFYTAKDPSYGENPSQLVAKFDVTNDLERSDILQATLTVSIEIPAKDSGMLQDVQVQVYEKNEDGSMGEMVTSGIFATKGSERISIQLPIDTVKSWFTISPIQGIFVKAMLDGRNVALHPQQTTADVDNMRLQLSTRPKGSRKRRSHAKPVCNAEAQSKGCCLYDLEIEFEKIGWDWIVAPPRYNAYMCRGDCHYNAHHFNLAETGHSKIMRAAHKVSNPEIGYCCHPTEYDYIKLIYVNRDGRVSIANVNGMIAKKCGCS
Protein: Tb-291 membrane associated protein, putative (Q381N6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWNFLIDIKNAARRTVAPTRDELAAAPEQKQQRSAAMSSGFSLLEEHVVGWMNKLTSSPVVLDSGAGSAELAGEYEKPPPLLCLAEEKRTSLEPEELFRYITESVSLITLTSKRIHGEAQFLLQLSLEEKITHTSDFLSVYTWWEDAVDQRLRKCELIFEEYKVQPGLINVENIVHLQQRINSIWETCTADMGTVKKIGTLLREEKYDLINQVGNDIPSEFAHQHDQNNDKTAKHRIIGSEAQPTGNKNSSLLHAQCTQESRVHTGEYVQNECTNKISTSSGKLHPRINESDTPAKKGKMRQHDGKEHLIRICKTSDNSEEETHLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEARLRAEEEACCGHSPHFSKLFAVLEHEEGVCRSIVCRKQADEYLTVYQKYIVSTSVSFVDEDESDHSENPSIVARLESVAAPSDRQDAGSVVGKSRIVKAKADILVDDEGEEWDDW
Protein: Nuclear hormone receptor FTZ-F1 beta (Nuclear hormone receptor HR39) (dHR39) (Nuclear receptor subfamily 5 group B member 1) (Q05192)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.
Subcellular location: Nucleus.
Interaction partners:
- Segmentation protein fushi tarazu
- Nuclear hormone receptor FTZ-F1
- Ecdysone receptor
Sequence:
MPNMSSIKAEQQSGPLGGSSGYQVPVNMCTTTVANTTTTLGSSAGGATGSRHNVSVTNIKCELDELPSPNGNMVPVIANYVHGSLRIPLSGHSNHRESDSEEELASIENLKVRRRTAADKNGPRPMSWEGELSDTEVNGGEELMEMEPTIKSEVVPAVAPPQPVCALQPIKTELENIAGEMQIQEKCYPQSNTQHHAATKLKVAPTQSDPINLKFEPPLGDNSPLLAARSKSSSGGHLPLPTNPSPDSAIHSVYTHSSPSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQARHAPPAGTLYGNHHGIYRQMKVEASSTVPSSGQEAQNLSMDSASSNLDTVGLGSSHPASPAGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCVRGGPCQVSISTRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPNSMLSPLLSPDQAAAAAAAAAVASQQQPHQRLHQLNGFGGVPIPCSTSLPASPSLAGTSVKSEEMAETGKQSLRTGSVPPLLQEIMDVEHLWQYTDAELARINQPLSAFASGSSSSSSSSGTSSGAHAQLTNPLLASAGLSSNGENANPDLIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSIDTPGEIKMSQGRKITLSQAKSNGLQTCIERMLNLTDHLRRLRVDRYEYVAMKVIVLLQSDTTELQEAVKVRECQEKALQSLQAYTLAHYPDTPSKFGELLLRIPDLQRTCQLGKEMLTIKTRDGADFNLLMELLRGEH
Protein: Deoxyribonuclease TATDN1 (H0YBX2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XSSLSVRGAFSTPLGLSDLSRASVTKVTGPRNCALRHYIGINLTDPMFRGIYRGVQKHQDDLQDVIGRAVEIGVKKFMITGGNLQDSKDALHLAQTNGMFFSTVGCHPTRCGEFEKNNPDLYLKELLNLAENNKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMKRNRDRCVGGV
Protein: Ring finger protein 38 (A0A8I5ZQX4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MREISPGANSAPLPGHPNKVICERVRLPSLFPLLPSDQDTTIQEDAHFKAFFQSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVRPNQHHFSGERCNTPARNRRSPPVRRQRGRRERLSRHNSISQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLLHPPHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLQVGSFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPVPPPTYHPSLLPYVLSMLPVPPTVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPSNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKGNRTCPICRADASEVHRDSE
Protein: NF-kappa-B-activating protein (Q9D0F4)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-processing factor 17
- Histone deacetylase 3
Sequence:
MAPVSGSRSPEREASGAKRRSPSRSPKSIKSSRSPRCRRSRSRSCSRFGDRNGLSHSLSGFSQSSRNQSYRSRSRSRSRERPSAQRSAPFASASSSAYYGGYSRPYGGDKPWPSLLDKEREESLRQKRLSERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEPKKSTTSASSSEDDKKKKRKSSHSKDRAKKKRKKKSSKRKHKKYSEDSDSDSESDTDSSDEDSKRRAKKAKKKDKKKKRRGKKYKKKKSKKNRKESSDSSSKESQEEFLENPWKDRSKAEEPSDLIGPEAPKTLASQDDKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMVYRKTKGKDDK
Protein: Plekha5 protein (Q8VDM7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPSHRAQILARCPEGYRTLPRNSKTRPESICSVTPSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPRHGCLSSPKAMVQVSDQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEVTSPIQRGDVTIDRRHRPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRTLSQDECRGTLYKYRPEEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRDQMQGQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETGLAGSKPFSSVKYKSEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSETEAPVVKGSHFPVGVPLRTKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLERIRRHQQACLREKKKGLSVLGASDPSDVRDSPLRLTQTLRRDDNVKELDTVHRENDVKPDYETPAAQYAHLEDAEPQNADIGRKLKRSESIFYEMLYTPEPNGMASEEVTEKERQKEQVHADGSCSPQEETAMTEHQMEGPPEEAESLHEEEETLASCEPAPEIPRENQTTAALASVESSQS
Protein: X-linked lymphocyte-regulated 4A (Q4QQJ8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MASKIKGRPPKQPKVTPALPSDDSQQLHENNPGNNLALETCGESSSSHGTGGPKPGPSKKTLNERKRKYGVSVNKTVQNIEWNVDHFLKVQHERRQELYKDYSHQFLTLVMMWNIDVDQIKKQAGKLSDILDEQQKLFQQFQSIHMQKIEEFKELCDRHLKNLQAIKCCCRKAIIEEARKLMDYLEKTVTEETVHVNKQEAKDGVQSSLLSLLIS
Protein: Uncharacterized RNA-binding protein C22E12.02 (Q10355)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Protein transport protein sec9
- U4/U6.U5 tri-snRNP-associated protein snu66
Sequence:
MSRVKTTVVRKAGGQVWEDPTLLEWDPNHFRLFVGNLGNDVNDESLYQAFSEYPSLVKTKVVRDREGKTRGFGFVSFKDSDQFLKAWREKNGKYIGSRPVKLSRATSDVKPNEVNEKTIDSKIRNSLYSRTIHHGNRVQKKIKNKHGKNSSKSSRAAQSAAAELISSSSITGARPANSTSVPNAVNTEISAARATESEASRNQTKASRDYSRASSFRRV
Protein: Protocadherin-19 (F8W3X3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000269|PubMed:21115806}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Cadherin-2
- Sodium channel protein
- Cyclin-dependent kinase-like 5
- Syntaxin-binding protein 1a
- Potassium channel, subfamily T, member 1.
- Nck-associated protein 1
Sequence:
MHSKDMDFVQMFVCFLLCWTGVDAVFNLKYTVEEELRAGTKIANVTADAKVAGFALGNRQPYLRVISNSEPRWVNLSPAGLLITKQKIDRDAVCRQTPKCFISLEVMSNSMEICVIKIEIIDVNDNAPRFPTNHIDIEISENAAPGTRFPLEGASDPDSGSNGIQTYTITPNDIFGLEIKTRGDGSKIAELVVEKTLDRETQSRYTFELTAEDGGDPPKSGTVQLNIKVIDSNDNNPVFDEPVYTVNVLENSPINTLVIDLNATDPDEGTNGEVVYSFINFVSNLTKQMFKIDPKTGVITVNGVLDHEELHIHEIDVQAKDLGPNSIPAHCKVIVNVIDINDNAPEIKLLSENSEMVEVSENAPLGYVIALVRVSDNDSGANGKVQCRLQGNVPFRLNEFESFSTLLVDGRLDREQRDMYNLTILAEDSGYPPLRSSKSFAVKVTDENDNPPYFTKPHYQAMVLENNVPGAFLLAVSARDPDLGMNGTVSYEIIKSEVRGMSVESYVTVNSNGEIYGVRAFNHEDTRTFEFKVSAKDGGDPPLTSNATVRIVVLDVNDNTPVMTTPPLVNGTAEVSIPKNAGVGYLVTQIKADDYDEGENGRLTYSISEGDMAYFEIDQINGEVRTTKTFGENAKPSYQITVVAHDHGQTSLSASAYIVIYLSPDLNAQEQIGPVNLSLIFIIALGSIAVILFVTMIFVAVKCKRDNKEIRTYNCRVAEYSYGNQKKSSKKKKLSKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNSRNAAPNHGYHHTFTGQGPQQPDLIINGMPLPETENYSIDSSYVNSRAHLIKSTSTFKDMEGNSLKDSGHEESDQTDSEHDVQRGHYADTAVNDVLNMTVPSNNSQIPDQDQSEGFHCQDECRILGHSDRCWMPRVPIPARAKSPEHGRNVIALSIEATTVDVPHYEDCGTTKRTFATFGKDGPDEDRAEQRGRRQTAEPAVCSPKTNGAVREAGNGREAVSPITSPVHLKSPQSKASSTYNTLKCRDAERIANHSLLRQPEGKDSEPAMREINTLLQDGRDKESPGSKRLKDIVL
Protein: CAAX prenyl protease (EC 3.4.24.84) (A0A1D8PL01)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU366005}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU366005}.
Interaction partners:
- intramembrane prenyl-peptidase Rce1
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Protein farnesyltransferase subunit beta
- Protein-S-isoprenylcysteine O-methyltransferase
- Protein-S-isoprenylcysteine O-methyltransferase
- Axl1p
- Metalloendopeptidase
Sequence:
MISLAESFAFLDSPSINWKTIIVGFTIGQYVFETYLDLRQYRVLQSKTAPKSIEKEVSQETFDKSQEYSRAKAQFSVFSSTFSLLQNLAIFKYDLLPKTWTLAGTIMKSSAAVLPKAMSGVITQSLFFVFTTQILTTLIGLPLSYYKNFVLEERFGFNKQTIGLWVSDMLKGIGISIVLGSPVIAGFLKIIDYFDDKFIFYLMGFILVVNLIAMTIVPTLIMPLFNKFTPLEDGELKTAIEKLALEQKFPLTKLFVIDGSKRSSHSNAYFTGLPWSKQIVLFDTLIEHNSTEETVAVLAHEIGHWKLNHLPKMITMMQGHLFLIFSLYSAFIHNKSLYTSFGFVKQQPILIGFMLFNDIFQPVECLLTFVSNLISRKHEYEADKYASDCGYSEELSRSLIKLSNENLSSMNADWLFSSYHYSHPILPERLSALGYVSKVKVKKDE
Protein: Probable inactive serine/threonine-protein kinase scy1 (N-terminal kinase-like protein) (SCY1-like protein kinase 1) (Q55GS2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Coatomer subunit delta
Sequence:
MYIFKLMGQNLTASQSFPYNIGPIVTGYVGKSIWTLHSGTKKEDGSAVSIFSFDIKKNPSKLEVAKNGFKRAKTTRHPNVLKYLDGLETETNIYIVTEPIQLLDELLEDIRNFENAISWGLYQEGLSFLNNKCNLTHGNIQSSSIFVNKGGDWQIGGLDFVSDVKDINNSILRNHNDLIPNKYKSPEIMKSQWQQIQQSPSYSIDSWMLGCLMYECYNGTMTKAEDIKNLDQIPKQLHQAYQKSFAVKTESRLNPQKFLESPYFQNVFVETLVFLENITLKDTFEKEQFFKKLDQHIEKIPINICKFKILPHLVTAFDLGPVNPRLLSTLLKIGSNLSTEEYNSRIVPSVVKWFACDDRALRINLLENLEHYIQHLNEATINDQIFPHVVNGFNDNPTLKELTIKSMLLFAPKLQEKTMIILLKYFAALQKDQQAGVRCNTTICLGRITEYMNEATKKRVLIPAFSTALKDPFVPSQNAAIQAFMFTISNYSLEELATRVIPEVSRMLISPEKSIRTSAFTAINMFLQKIEKNVDSILPSSPQQQQQNGSTLNTNPNDPNQNSQDSMLGWAVGITKKLYSGENSPITATNNNNNTNTPPINQNNNNGYKSPPINQNNNQNNNQNNNQNNNQNNNQNNKSLQNKQPTKVIHDGWGDNDYQEPPKKQTTTNTPSKSSKYKVEDNDDDDDDDEDYQEEDYSKYKEDLPRLTPKPSSTSSSSSSTSNKLDNKPMSLVSKNKPKYSFDEEDTSSSSSNIVNKNNNNKNNNSDGWGDDDGWGNDEIQVPSTTTSNIKKTVEKKTIVTASKSDGWDDGWD
Protein: Transcriptional regulator, LysR family (Q92Y01)
Organism: Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Interaction partners:
Sequence:
MTFGFDLDLLRAFTAVVETGGFTRAAERVHRTQSTISQQIKKLETNLGHVLLIRDRATGSVRTTEEGELLMSYARRILSVSAEANEALGRSMPSPKTVRLGVPEDFAGRRMIDLLSGFARASPRTRLDTISGWSFELRRLLQAGEIDLALVKREPGDGACIAKWEERLVWIGDPLLAVGNDPVPLAVFPSGCIYRERVIRAVERSGKAWRIAYSSQGLMGVQAAVASGLGISLLPNDAVLPEHRLLHETDGFLPEPASELALITVAKKLDPALQDLVDYLLASLKAMKFT
Protein: Large ribosomal subunit protein uL30z (60S ribosomal protein L7-1) (Q9SAI5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g43860
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein uL24c
- Large ribosomal subunit protein eL27z
- Ribosome biogenesis protein BOP1 homolog
- 50S ribosomal protein L33
- Large ribosomal subunit protein eL42z/eL42y
- Small ribosomal subunit protein eS28x
Sequence:
MAEEEAKGLDYIPEIVLKKRKNRDELAFIRKKQLELGNSGKKKKKVSDIKRPEDFVHEFRAKEVDMIRMKQRVKRPKSSPPPVKSDLVFIIRIQGKNDMHPKTKRILNNLQLKSVFTGVFAKATDSLFQKLLKVQPYVTYGYPNDKSVKDLIYKKGCTIIEGNPVPLTDNNIIEQALGEHKILGIEDLVNEIARVGDHFREVMRFLGPLKLNKPVADVLHRKKQVFSEGGDTGNREDKINDLISKMN
Protein: Free fatty acid receptor 2 (G-protein coupled receptor 43) (O15552)
Organism: Homo sapiens (Human)
Function: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate. Exhibits a SCFA-independent constitutive G protein-coupled receptor activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18801738}; Multi-pass membrane protein {ECO:0000269|PubMed:18801738}.
Interaction partners:
- Free fatty acid receptor 4
- G-protein coupled receptor 84
- Pro-glucagon
- Peptide YY
- Pro-neuropeptide Y
- Appetite-regulating hormone
- Free fatty acid receptor 3
- B-cell receptor CD22
- G-protein coupled bile acid receptor 1
- Galanin peptides
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
Protein: Glutamyl-tRNA reductase-binding protein, chloroplastic (AtGluTRBP) (GluTR-binding protein) (Protein PROTON GRADIENT REGULATION 7) (Q9LU39)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis. Stimulates GluTR activity and regulates glutamate-1-semialdehyde release. May play a role in heme metabolism. Necessary for efficient photosynthetic electron transport in chloroplasts.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:20657737, ECO:0000269|PubMed:22180625}. Note=Detected at low levels in thylakoids. {ECO:0000269|PubMed:20657737, ECO:0000269|PubMed:22180625}.
Interaction partners:
- Glutamyl-tRNA reductase 1, chloroplastic
- Protein FLUORESCENT IN BLUE LIGHT
- Probable glutamyl-tRNA reductase 3, chloroplastic
- Glutamyl-tRNA reductase 2, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 2, chloroplastic
- ATP-dependent Clp protease ATP-binding subunit CLPT1, chloroplastic
- Glutamate--tRNA ligase, chloroplastic/mitochondrial
- Glutamate--tRNA ligase, cytoplasmic
- Clp protease adapter protein ClpF
- Chaperone protein ClpC1, chloroplastic
Sequence:
MQLQTQSFALNLLPSPNFAKPIERREFISLKRDPSRPISLRCSVSTTLDTPATASTHKPFPAEVSRSIMELSSVGTLSTLTHDGWPLGVGVRFAVDKDGTPVLCLNRSVSPDKRSALHVQLEQCGLRTPQCTIQGSIGRPGDDTVLKRLSATWREKFGEEVKEDSLYVVAVDRVLQMEDFMEDGIWVASSDYKNASPDPLRDIAEDIVNQINANNMEDIFRFCNVYVDLDFVVSETKMIWMDRLGFDLRVWSPRGVYDVRIPFPMEVTDEKGAKSSFNGMSQLAWEVEKSYCPADFNKVKLLKQVVGSSHSHKGGGQ
Protein: Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) (Q57YG1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase
- Peptidyl-prolyl cis-trans isomerase
- peptidylprolyl isomerase
- peptidylprolyl isomerase
Sequence:
MSEKLRAAHLLVKFSGSRNPVSRRTGDSTADVTYEDAIKELQKWSQRIASGEVSFEEAASQRSDCGSYASGGDLGFFSSGEMMKPFEDAVRALKIGDISPIVQTDSGLHIIKRLA
Protein: Interferon alpha/beta receptor 1a (Membrane-associated type I interferon receptor) (mIFNAR1) (Type I interferon receptor 1a) (K7NA32)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P17181}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P17181}.
Interaction partners:
Sequence:
MKVGFALVLLWSLPITNVLAELPQPQNLTLLTLNTQYVLTWDWDQTTTGNSVSFTVEYMAKYKMKMKKKNWSRVCERTTRTRCDLTGSDLHYLGMYVLRVRASADGVNSDWVNKDFCPDIDASLGPPSRVELAPVGNLLDVTISDPLTSTQHSMKEHVLFLYYRILYWSRSDDPQGLKPKVLDSSNNLVTLPELEAWTWYCVMIQSRYDYYNKTSSYTEPQCMQTEGDTPYGQIFLYFLVSMMVCFLLVLLSSYAFFRFYRGLKNTFYPSIQLPAHIQEYLCDSSPGSDMPRLITADSEAELCCDKLTICPEVVLLEIHVPPPLTAPPSELEQDSGRRIRQDSGDSGIYSTEGGSAQQGRSGGEPIRRDQEVDSWQTLEQVKMEEMGRELADERDLDEGVVDICV
Protein: Putative transferase CAF17 homolog, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog) (Q8CAK1)
Organism: Mus musculus (Mouse)
Function: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Iron-sulfur cluster assembly 2 homolog, mitochondrial
- Iron-sulfur cluster assembly 1 homolog, mitochondrial
- NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
- Lipoyl synthase, mitochondrial
- LYR motif-containing protein 4
- Cysteine desulfurase
- Iron-sulfur cluster assembly enzyme ISCU
- Ferredoxin-2, mitochondrial
- Iron-sulfur clusters transporter ABCB7, mitochondrial
- Glutaredoxin-related protein 5, mitochondrial
Sequence:
MAAVALLRGAAVGRRSPAWHWRLSGTASHCLARGFGLLGSNPADGVAWTCFRLDGRALVRVRGPDAAPFLLGLSTNELPLSGPPTGAAQPSARAAYAHFLNVQGRTLYDVILYGLPECTEGAPSFLLECDSSVLGALQKHLSMYKIRRKVTVEPSPELHVWAVLPCVPQTSETAPLEERVEGTTMLIRDPRTARMGWRLLTQDDGPALVPRGQLGDLQDYHKYRYQQGIPEGVCDLPPGMALPLESNLVFMNGVSFTKGCYIGQELTARTHHTGVIRKRLFPVKLEGPLPASGVSPGAIVTVTATGQAAGKFRAGQGHVGLALLRSETIKGPLHIKTSESQLVAVTAVVPDWWPTAAK
Protein: Probable copper-exporting P-type ATPase (EC 7.2.2.8) (Copper-exporting P-type ATPase A) (Cu(+)-exporting ATPase) (O29777)
Organism: Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Function: Probably involved in copper and silver export.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Transcriptional regulatory protein, AsnC family
- Copper chaperone CopZ
- Metal-dependent hydrolase
- Metal-dependent hydrolase
- Transcriptional regulatory protein, AsnC family
- Transcriptional regulatory protein, AsnC family
Sequence:
MVKDTYISSASKTPPMERTVRVTGMTCAMCVKSIETAVGSLEGVEEVRVNLATETAFIRFDEKRIDFETIKRVIEDLGYGVVDEQAAVSAEVEHLSRMKRKLYVAAFAGVLLLFLAHFISLPYEDFVQLLIALPAIFYSGSSIFKAAFSALRRRTLNMDVMYSMGVGAAFLASVLSTAGVLPREYSFYETSVLLLAFLLLGRTLEARAKSRTGEAIKKLVGLQAKTAVVIRDGKEIAVPVEEVAVGDIVIVRPGEKIPVDGVVVEGESYVDESMISGEPVPVLKSKGDEVFGATINNTGVLKIRATRVGGETLLAQIVKLVEDAMGSKPPIQRLADKVVAYFIPTVLLVAISAFIYWYFIAHAPLLFAFTTLIAVLVVACPCAFGLATPTALTVGMGKGAELGILIKNADALEVAEKVTAVIFDKTGTLTKGKPEVTDLVPLNGDERELLRLAAIAERRSEHPIAEAIVKKALEHGIELGEPEKVEVIAGEGVVADGILVGNKRLMEDFGVAVSNEVELALEKLEREAKTAVIVARNGRVEGIIAVSDTLKESAKPAVQELKRMGIKVGMITGDNWRSAEAISRELNLDLVIAEVLPHQKSEEVKKLQAKEVVAFVGDGINDAPALAQADLGIAVGSGSDVAVESGDIVLIRDDLRDVVAAIQLSRKTMSKIKQNIFWALIYNVILIPAAAGLLYPIFGVVFRPEFAGLAMAMSSVSVVANSLLLRNYVPPIRRGGDSVEKIVLELSGLSCHHCVARVKKALEEAGAKVEKVDLNEAVVAGNKEDVDKYIKAVEAAGYQAKLRS
Protein: ORF 31 (P88920)
Organism: Human herpesvirus 8 type M
Interaction partners:
Sequence:
MSQNRKTLPADGPGGHGVLCEGVPPRHRCEMKSVASPLCQFHGVFCLYQCRQCLAYHVCDGGAECVLLHTPESVICELTGNCMLGNIQEGQFLGPVPYRTLDNQVDRDAYHGMLACLKRDIVRYLQTWPDTTVIVQEIALGDGVTDTISAIIDETFGECLPVLGEAQGGYAMVCSMYLHVIVSIYSTKTVYNSMLFKCTKNKKYDCIAKRVRTKWMRMLSTKDT
Protein: Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 2, mitochondrial (UDP-3-O-acyl-GlcNAc deacetylase 2) (EC 3.5.1.108) (Protein LIPID X C2) (AtLpxC2) (UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase 2) (P0DKB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21709257, ECO:0000305|PubMed:25732537}.
Interaction partners:
- Probable UDP-3-O-acylglucosamine N-acyltransferase 1, mitochondrial
- Probable UDP-3-O-acylglucosamine N-acyltransferase 2, mitochondrial
- Probable acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, mitochondrial
- Probable lipid-A-disaccharide synthase, mitochondrial
- Probable tetraacyldisaccharide 4'-kinase, mitochondrial
- Probable 3-deoxy-D-manno-octulosonic acid transferase, mitochondrial
- Is a member of the PF|00364 Biotin-requiring enzymes family
- adenylate kinase
- Uncharacterized protein
- Uncharacterized protein At2g34110
Sequence:
MRLPVTVKATKPSFLVIWIRYSSAASSPTVSLNPSGRLQQTLAGSVEVKGKSLHSGKFSTVKLNPEIAGAGRFFEFRSRFIPASIEFAQESPLCTTLLKDELKIRTVEHLLSALEAKGVDNCRIQIESESSDDREVEVPIFDGSAKEWVDAIQGVGINAAQNHDGESVEKMVAHVNKPVYVCKNDTFVAAFPALETRITCGIDFPQVPAIGCQWFSWRPIHESSFAKDIASSRTFCVYEEVERMREAGLIKGGSLDNAIVCSAEHGWMNPPLRFDDEACRHKILDLIGDLSLVSRGGNGGLPVAHIVAYKAGHALHTDLARHLTMD
Protein: Protein anoxia up-regulated (C0HK95)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an important role in the regulation of tissue responsiveness to oxygen deprivation.
Interaction partners:
- Uncharacterized protein CG45078
- Uncharacterized protein CG45076
- LP20791p
- Uncharacterized protein, isoform B
- FI03418p
Sequence:
MVYESGFTTRRTYSSRPVTTSYAVTTPRLDLCTDRPGSHRSRASSDYSYTSKSSVEKSSYDSSNPHSYRPERSTYTSTVEKTSRSGPGGSYNYSTERTSTTGAGPGGYSYSSTTSGNLPGGTKYRHFSYHV