wanglab/gogpt-training-data huggingface dataset:
Protein: LD29171p (Secretory 71) (Q9VJW1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- ADP-ribosylation factor-like protein 1
- RE14391p
- ADP-ribosylation factor 6
- ADP-ribosylation factor 1
- RT07631p
- Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
- Protein MON2 homolog
- Guanine nucleotide exchange factor MSS4 homolog
- Translocation protein SEC62
Sequence:
MHNNSTKTKEMFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAALPLPKNDAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTIYGCFSGPQTDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNLVNQTTARATLTQMLNVIFARMENQVYELPPPNSNPTNGSIHSEDCNGSGEESLRDSDEVIASELLAEIISAAYNEAMKDQESVGEPEPTLNGNDYSSHSDHDSVELHSENDAVVTAKFTHILQKDAFLVFRALCKLSMKPLPDGHPDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLCVALSNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILEANSSSFEHKWMVIQALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQEKSMRIRGLECLVSILKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQADTTIQTMHSGSSHSLNSNQEQLQDLPEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNANSPINEMKAKNIDTIKTLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGVRPQFLSGAQTTLKDSLNPSVKEHIGETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALCQVSVDELQQQQPRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEEISFFALDSLRQLSMKFMEKGEFSNFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQMVNSQAHNIRSGWKNIFSIFHLAAGDNEEPIVELAFQTTGKIIGDLYKRQFAIMVDSFQDAVKCLSEFATARFPDTSMEAIRLVRTCAQCVHEAPQLFAEHAGMENDASVAEEDRVWVRGWFPMLFSLSCVVNRCKLDVRTRALTVLFEIVKTYGESFKPHWWKDLFNVIFRIFDNMKLPEHVTEKSEWMTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAQLHWCVQQSNEQLARSGTNCLENLVISNGFKFNESTWDKTCQCILDIFNATLPQDLLSWRPKAHSSNNIPQEHNHFEALHIRCVVQLELIQTMDNIVFFPATSRKEDAETLAQAAADLTGGRSGSQSQLLECQREEQGMYGYLRTRQLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVKPNLLKQETSSLACVLRIFFKMYGDENRRSDWPGIEQELVQVCKEALGYYLSLQSEAHRDAWTSLLLLILTRLLKMSDARFATHVSNYYSLLCEMMCFDLKPELRSVLRRVFMRIGPVFNIMSVK
Protein: Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1) (Q7JQD3)
Organism: Lumbricus terrestris (Common earthworm)
Function: Calcium-regulated protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Can promote the assembly of monomers into filaments (nucleation) as well as sever existing filaments.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P06396}.
Interaction partners:
Sequence:
MATGLIKAKEYDWKDSNLALFGSDTEKQVKKDSAATEPAWKGAGQKEGLKIWRIVNFKVTEWPQNQHGKFYNGDSYIILNTYKPDPKSNELAYDVHFWIGSQSSQDEYGTAAYKTVELDTFLDDKPVQHREVQGYESELFRNYFKQGLTILEGGAETGFHHVKPTEYKPRLLHFSGQKQQIYVHEVPLVKERLDHKDVFILDLGLTLYQWNGKESSKEEGFKAMQYLGLMRSERPKAEAETLEDESTPESHKFYTSLTGTDEPNLVKPLVKEENQLLKVSDAGGHLKTTEVKRGAVNSKDFSSNDVFILDTGDQCFVWVGKGRFAVGEAEWTRISHAHLMKTCHPLAPIHVIKEGQLCKAFNVAIAA
Protein: Ubiquinol oxidase 4, chloroplastic/chromoplastic (EC 1.10.3.11) (Alternative oxidase 4) (Plastid terminal oxidase) (Protein IMMUTANS) (Q56X52)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts early in chloroplast biogenesis as a component of a redox chain responsible for phytoene desaturation. Prevents the generation of toxic oxygen radicals and photooxidation of the nascent photosynthetic apparatus. Involved in the differentiation of multiple plastid types, including chloroplasts, amyloplasts, and etioplasts. Might participate in the chloroplast respiratory chain.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:14504923, ECO:0000269|PubMed:9878632}; Multi-pass membrane protein {ECO:0000269|PubMed:14504923, ECO:0000269|PubMed:9878632}; Stromal side {ECO:0000269|PubMed:9878632}. Plastid, chromoplast membrane {ECO:0000269|PubMed:10938359}; Multi-pass membrane protein {ECO:0000269|PubMed:10938359}. Note=localized to the stromal thylakoid lamellae. {ECO:0000269|PubMed:14504923}.
Interaction partners:
- Protein PROTON GRADIENT REGULATION 5
- 15-cis-phytoene desaturase, chloroplastic/chromoplastic
- Zeta-carotene desaturase, chloroplastic/chromoplastic
- Internal alternative NAD
- Photosystem II 22 kDa protein, chloroplastic
- At4g12990
- Uncharacterized protein At2g22460/F14M13.14
- Serine/threonine-protein kinase STN7, chloroplastic
- ATP-dependent zinc metalloprotease FTSH 2, chloroplastic
- ATP-dependent zinc metalloprotease FTSH 1, chloroplastic
Sequence:
MAAISGISSGTLTISRPLVTLRRSRAAVSYSSSHRLLHHLPLSSRRLLLRNNHRVQATILQDDEEKVVVEESFKAETSTGTEPLEEPNMSSSSTSAFETWIIKLEQGVNVFLTDSVIKILDTLYRDRTYARFFVLETIARVPYFAFMSVLHMYETFGWWRRADYLKVHFAESWNEMHHLLIMEELGGNSWWFDRFLAQHIATFYYFMTVFLYILSPRMAYHFSECVESHAYETYDKFLKASGEELKNMPAPDIAVKYYTGGDLYLFDEFQTSRTPNTRRPVIENLYDVFVNIRDDEAEHCKTMRACQTLGSLRSPHSILEDDDTEEESGCVVPEEAHCEGIVDCLKKSITS
Protein: Transcription factor 12 (TCF-12) (Class A helix-loop-helix transcription factor ME1) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) (Q61286)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). May be involved in the functional network that regulates the development of the GnRH axis (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- T-cell acute lymphocytic leukemia protein 1 homolog
- Myogenin
- Runt-related transcription factor 1
- Myoblast determination protein 1
- Protein CBFA2T1
- Rhombotin-2
- LIM domain-binding protein 1
- Achaete-scute homolog 1
- Trans-acting T-cell-specific transcription factor GATA-3
- Twist-related protein 1
Sequence:
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGMDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGTHEGLSPTPFMNSNLIGKTSERGSFSLYSRDSGLSGCQSSLLRQDLGLGSPAQLSSSGKPGTPYYSFSATSSRRRPLHDSVALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHSSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGSLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSPSPLTGTSQWPRAGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPTSHSDIHSLLGPSHNASIGNLNSNYGGSSLVTNSRSASMVGTHREDSVSLNGNHSVLSSTVAASNTELNHKTPENFRGGVQNQSGSVVPTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAASAEPPNTLPGAHPGLSESTNPMGHL
Protein: Protein transport protein GOT1 (Golgi transport protein 1) (Q03554)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex. Can be replaced by SFT2.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:10406798}; Multi-pass membrane protein {ECO:0000269|PubMed:10406798}.
Interaction partners:
- Dihydroorotate dehydrogenase
- Orotate phosphoribosyltransferase 1
- Orotidine 5'-phosphate decarboxylase
- Orotate phosphoribosyltransferase 2
- Protein transport protein SFT2
- ER-derived vesicles protein ERV14
- Uncharacterized protein YJL213W
- Uncharacterized transcriptional regulatory protein YLR278C
- Allantoinase
- ATPase GET3
Sequence:
MWLTEAQKFGVAFTFGGFLFFLFGIFTFFDRALLALGNILFLIGVFLIIGSQKTYIFFTRPNKRRGSLFFLVGAFLILLKWTFLGFIIESLGIIGLFGDFFGVIVQFLRSMPIIGPILSHPAIAPIVDKLAGVRVLPV
Protein: Programmed cell death protein 10 (TF-1 cell apoptosis-related protein 15) (Q8VE70)
Organism: Mus musculus (Mouse)
Function: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BUL8}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6NX65}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NX65}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6NX65}. Cell membrane {ECO:0000269|PubMed:20371769}; Peripheral membrane protein {ECO:0000269|PubMed:20371769}; Cytoplasmic side {ECO:0000269|PubMed:20371769}.
Interaction partners:
- Serine/threonine-protein kinase 25
- Serine/threonine-protein kinase 26
- Cerebral cavernous malformations protein 2 homolog
- Striatin
- Serine/threonine-protein kinase 24
- Striatin-interacting protein 1
- MOB-like protein phocein
- Striatin-3
- Striatin-4
- Sarcolemmal membrane-associated protein
Sequence:
MRMTMEEMKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRLIHQTNLILQTFKTVA
Protein: BifA (Q9HW35)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- diguanylate cyclase
- Probable phosphodiesterase
- Transcriptional regulator FleQ
- histidine kinase
- Protein-glutamate methylesterase/protein-glutamine glutaminase 3
- High-affinity zinc uptake system protein ZnuA
Sequence:
MKLDSRHSLSLKLLRVVLLAALAVGVVLSCAQIVFDAYKAKQAVSSDAQRILAMVRDPSTQAVYSLDREMAMQVLEGLFQHEAVRQASIGHPGEPMLAEKSRPLLDLPTRWLTDPILGQERTFSIRLIGRPPYSEYYGDLKITLDTAPYGENFVTTSEIIFISGILRALAMGLVLFLVYHWMLTKPLSKIIEHLVSINPDRPSQHQLPLLKGHERNELGLWVTTANQLLASIESNSHLRREAEDNLLRISQYDFLTGLPNRQLLQQQLDQILDGAGRQQRRVAVLCLGLDDFKGINEQYTYQLGDQLLIALADRLRGHSARLGSLARLGGDQFALVQADIEQPYEAAELAQSILDGLEAPFEIDQHEVRLRATIGITLFPEDGETTEKLLQKAEQTMTLAKTRSRNRYQFYIASVDSEMRRRRELEKDLRDALQRHELHLVYQPQVDYRDHRVVGVEALLRWQHPLHGFVPPDLFIPLAEQNGSIFSIGEWVLDQACRQLREWHDQGFDDLRMAVNLSTVQLHHNALPRVVSNLLQVYRLPARSLELEVTETGLMEDISTAAQHLLSLRRAGALIAIDDFGTGYSSLSYLKSLPLDKIKIDKSFVQDLLQDEDDATIVRAIIQLGKSLGMQVIAEGVETAEQEAYIIAEGCNEGQGYLYSKPLPARELTQYLKQARRLSQATSSERP
Protein: Protein AIG2 B (EC 2.3.2.-) (Avirulence-induced gene 2 protein B) (Putative gamma-glutamylcyclotransferase) (Q9MBH2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative gamma-glutamylcyclotransferase.
Interaction partners:
Sequence:
MTSSDKSLSHDVFVYGSFQEPSVVNLILECSPVMVPAQLHGYHVYRLKGRLHACISPSENGLINGKILTGLTDSQLENLDMIEGSEYVRKTVEVVLTDTSEKKQVETYVWANKDDPNLYGEWDFEEWRRLHMDKFIEASTKFIEWKKNPDGRSREEFEKFVFDDPPTAA
Protein: ADP-ribosylation factor-like protein 11 (ADP-ribosylation factor-like tumor suppressor protein 1) (Q969Q4)
Organism: Homo sapiens (Human)
Function: May play a role in apoptosis. May act as a tumor suppressor.
Interaction partners:
- P2X purinoceptor 7
Sequence:
MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLVLANKQEAPDALPLLKIRNRLSLERFQDHCWELRGCSALTGEGLPEALQSLWSLLKSRSCMCLQARAHGAERGDSKRS
Protein: Discs large 5, isoform D (M9PD90)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAKMASGDLSLTSTSSQEESSEYVGYDNTLRPPSNSSGSTTAANMSNNNGPSKGVSSGVGVSGISGGNGANYDILQAQYKSALLELNTLRHQHANTKRRCDELATELTLYQEHYVADRNKFTDMVEESARFKRLLLETQNQQSQQAQNGNSQVPPVGSGNPYYFGKTQGCDGSCSEKLAELKKERNMVAVEREKYKKSYIELEKDRNYYRERGDENQKLKVLLSQESKNVLSLTEELNQLLSEKDNVLQEHQKMSDDLVLANKEIERLKKDEQLARAEIKVLQLANADLKKRDLLKSRDSSWSKEFPSGKELENSKELEKLRKSLEKALSEVERSSQDAEEAKRVRDWAISQREKIVQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLEVELSGYEHTSDLGIILDDSNKRKLVCGVTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVSRTRHSKRHAYSVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKKEKEASKSMGTWPRTNISHENPTGTMRGNEKKRALMSLFTAGPINVDKDDELMGEVGVPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRPHSNHRLSLNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSGEVVDCDTGTARRGSTSARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLCEVTAMDCSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVPVSSG
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (H1UUC2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MICVAGVRLQLPTAPPTYSIYSSIFPLRRGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERIHGWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFYTWLPPMQVPL
Protein: Beta-secretase 2 (EC 3.4.23.45) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase) (Q6IE75)
Organism: Rattus norvegicus (Rat)
Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9Y5Z0}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000250|UniProtKB:Q9Y5Z0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Y5Z0}. Endosome {ECO:0000250|UniProtKB:Q9Y5Z0}. Melanosome {ECO:0000250|UniProtKB:Q9Y5Z0}. Note=Colocalizes with PMEL in stage I and II melanosomes. {ECO:0000250|UniProtKB:Q9Y5Z0}.
Interaction partners:
- Reticulon-3
- Reticulon-4
- Beta-secretase 1
- Amyloid-beta precursor protein
- Tyrosine-protein kinase Fyn
Sequence:
MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGLALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK
Protein: Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) (A0A2R8Y5A0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369118}.
Interaction partners:
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
Protein: Cell adhesion molecule CEACAM20 (Carcinoembryonic antigen-related cell adhesion molecule 20) (CEA cell adhesion molecule 20) (Q9D2Z1)
Organism: Mus musculus (Mouse)
Function: Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response.
Subcellular location: Cell projection, microvillus membrane {ECO:0000269|PubMed:25908210, ECO:0000269|PubMed:26195794}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:25908210, ECO:0000269|PubMed:26195794}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with PTPRH and CEACAM1 at the apical brush border of intestinal cells. {ECO:0000269|PubMed:25908210, ECO:0000269|PubMed:26195794}.
Interaction partners:
Sequence:
MELAGFHCCSWTVILLSALLPTTWRPPAAAHFIHRADLLSNTQMERAPLAKLTLTVNQSTVTEQREMAVFYCNTNADNITIHWVSNNSLLVLNERMKLSADNKTLTILIVQREDSGSYLCEVQHGFEVQRSNTASLTVNYGPDPVSIKLDSGVAAGDVVEVMEGNTVNFRVEAQSSPVPAYAWYLPSDFIQPPTTGTFTIDAVSREHEGMYRCLVSNPVTNLSRLGVVKVQVLEKVTAPNIEFPTLALVENATSVTLTCKTSHQRVGVHWFLKGQPLRPSDRLTLSSQNRTLTIHGLQRDDIGPYECEVWNWGSQARSVPLKLTINYGPDQVEITQGPASGVVSTIEAMLNSSLTLYCRADSIPGARYQWTHEHSSKVLDGEQLSIEALRQEHQGIYSCTSSNDVTGLARSASVLVMVVGLQSSSMSPGAIAGIVIGILVAIALAIGLGYFLYSTKDRWTRRRSASDTTSSNTIPPTSVMQSTPESRHNKPMTVYDNTPKPEGEARGKKMWSLPRDSPEQFYEKKPPSAAPEGPRKPLPQIPKQPLMPPGPGRNEESNYEKLLNSNHSLYCKITPSA
Protein: WT1 transcription factor (H0Y7K5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MDFLLLQDPASTCVPEPASQHTLRSGPGCLQQPEQQGVRDPGGIWAKLGAAEASAERLQGRRSRGASGSEPQQMGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
Protein: PX domain-containing protein (D9PTP7)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKPETAVVREHEEFLWLHGTLEDNENYAGFIIPPAPPKPNFDSSREKLQKLGEGEATMTKEEFLKMKHDLEQDYLAQFKKTVAMHEVFLQRIAAHPVFKNDQNFRIFLQYENELSVRGKNKKEQVESFWKRFTQSADEVLLSGQKDVDEFFEKEKNYMVEYNIHIKEAAAKSEKLIAARKNVVASFSKIGDSFERIARGEPNKSLARTFAQGADAMFKLKKVESRSSNDEELKLGDTLHYFARDTQAAKDLLYRRMRCLANYEAANKNLERARAKNREIPKAEAEQSEACKKFEEITGLSKNELKELKTRRVQAFKKNLTDLAELEIKHSKAEISLLRDVVERLKSSQ
Protein: Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2) (P11168)
Organism: Homo sapiens (Human)
Function: Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28083649}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Hexokinase-4
- Hepatocyte nuclear factor 1-alpha
- Insulin
- Cellular tumor antigen p53
- Solute carrier family 2, facilitated glucose transporter member 1
- Sodium/glucose cotransporter 1
- Pro-glucagon
- Neurogenic differentiation factor 1
- Homeobox protein Nkx-6.1
- Neurogenin-3
Sequence:
MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV
Protein: Serine/threonine-protein phosphatase SIT4 (EC 3.1.3.16) (Q59KY8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Serine/threonine protein phosphatase which is involved in the dephosphorylation of the large subunit of RNA polymerase II. Is required in late G1 for normal G1 cyclin expression, bud initiation and expression of certain genes that are periodically expressed during late G1 (By similarity). Plays a role during hyphal growth through the regulation of cell wall biogenesis, osmosensing and protein translation. Involved in virulence in a mouse systemic infection model.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Uncharacterized protein
- Type 2A phosphatase-associated protein 42
- Uncharacterized protein
- Pho81p
- Protein phosphatase 2A structural subunit
- Protein phosphatase PP2A regulatory subunit B
- Serine/threonine-protein phosphatase 2A activator 1
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
- Uncharacterized protein
- non-specific serine/threonine protein kinase
Sequence:
MGERGPDQWLEQIKNCISLSESDMKQLCELVKELLMEESNIQPVQSPVTVCGDIHGQFHDLLELFRTAGGLPSDDNQTNFIFLGDYVDRGYFSLETFTLLMVLKVKYPHRITLVRGNHESRQITQVYGFYEECLTKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFCDLVWSDPDNIDTWAVSPRGAGWLFGSKVSREFNHINNLQLIARAHQLVMEGFRYHFKEKDVVTVWSAPNYCYRCGNVASVMQVDEDLEPNFKIFSAVQDGDLSVKNNANKQQRSDYFL
Protein: Nuclear pore complex interacting protein family member B2 (F8VY45)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFCCLGYEWLSGGCKTWHSAWVINTLADHHHRGTDFGGSPWLRIIIAFPRSYKVVLTLWTVYLWLSFLKTIFQSENGHDVSTDVQQRARRSNRRRQEGNKIGLKDVITLRRHVETKGRAKIRKMKVTTKINHHDKINGKRKTAKKQKLSVKECEHAEKERQVSEAEENGKLDMKEIHTYMKMFQRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKTPPECLLTPLPPSADDNLKTPPECLLTPLPPSAPPSADDNLKTPPLATQEAEAEKPPKPKRWRAAEMESPPEPKRRRAAEVESPPEPKRRRAAEVEPSSPEPKRRRLSKLRTGHCTQA
Protein: CUE domain-containing protein (Q38A64)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAKTLSDAFPDTDGAICQSFFQSTDFGEKTWQEVGLYAQCDERTFWTVVANHKNVAIVLKQLVDAVNTAHSSAFSRKLQPTDENSVVTIFVRVASTTSTVLAAGASISSLANRLTEIIAPSLLVSVSVMLLRHSGTIASAAVTGLILLNPAYLCAMPSIINSWCDATSSLAAQCCRDLSRGRHQRLAGDVVPFFENAYRHMKQLWSLMHCAPFLAEYVPLSRALSCLRVVVDLISPALQHFVLTCDALVNHRGQLSKANSVIVNAAVNTASILVLFRTYRLAYGEGRSYCVDHVVESTYESITGYITKKVSGAPALLLSNPTWPLTSVLHELVLPRHEDRDFRLGKLFGLLNESVQDSKDFADGFAGCRPRFFEILLLELVHQSFHIDSLLEKHLVTATEAEEWGASERTITQAIAGIVDKSKGSCASPPGDCGDIVNPPIPPHRHGTSSNPLVNIVLDVMPHFNVKGIEAALSYYNNDVEHFILDASMEYIVPHIFEQLMEPEPSLIAEMLRDEDDDTMRGTEVPPAQQHVITSEDYDNELEGVDINLLIGCDLYEAINGSAEQISCNDFSEEFQYSTLHSGDHGHHNVGGTFEVDEVLKEKIRMLTEMMYEDEYDDTQDGTEVRGLGKQFNTDDVESLSSGEERNENYEVTHGNEGVATEDASAAPTSSDGFAAMPSNTATHRPRTLYDEKRFHMDRTKQHDARVKAVREAKQNTPSYTKKKKTMQRKPRDSGALTRAARKGRLE
Protein: Tribbles homolog 2 (TRB-2) (Q28283)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9342215}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:9342215}. Note=May associate with the cytoskeleton.
Interaction partners:
- COP1 E3 ubiquitin ligase.
Sequence:
MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSGYGAKEVSDQLVPDVNMEENLDPFFN