wanglab/gogpt-training-data huggingface dataset:
Protein: Laminin subunit gamma-3 (Laminin-12 subunit gamma) (Laminin-14 subunit gamma) (Laminin-15 subunit gamma) (Q9Y6N6)
Organism: Homo sapiens (Human)
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.
Interaction partners:
- Laminin subunit beta-1
- Laminin subunit alpha-4
- Laminin subunit beta-2
- Laminin subunit alpha-2
- CD44 antigen
- Cell division control protein 6 homolog
- Nidogen-1
- DNA replication factor Cdt1
- Laminin subunit alpha-3
- Integrin alpha-10
Sequence:
MAAAALLLGLALLAPRAAGAGMGACYDGAGRPQRCLPVFENAAFGRLAQASHTCGSPPEDFCPHVGAAGAGAHCQRCDAADPQRHHNASYLTDFHSQDESTWWQSPSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSASCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEHPPQWSPNGVLLSPEDEEELTAPEKFLGDQRFSYGQPLILTFRVPPGDSPLPVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPLPPFHFQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLTSARPGLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCNQHGTCDPNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCHENGTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLDILLGEAPRGDVYQGHHLLPGAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLESSEEEILHAAAILASLEIPQEGPSQPTKWSHLATEARALARSHRDTATKIAATAWRALLASNTSYALLWNLLEGRVALETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGADTAPYLALLASPGALPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSSVQAATVTVMGARTLLADLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQAHRRASRLTSQTQATLQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQALNETQWALERLRLQLGSPGSLQRKLSLLEQESQQQELQIQGFESDLAEIRADKQNLEAILHSLPENCASWQ
Protein: Deoxycytidine kinase (D6RFG8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKSCSVAQAGVQWHNLGSLPSPPPRFNQFCLSLLSQRVFEYFVILLKTTGSQMVPDTSALCIFVTSY
Protein: Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69) (Q07108)
Organism: Homo sapiens (Human)
Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
Subcellular location: Cell membrane {ECO:0000269|PubMed:37039481}; Single-pass type II membrane protein.
Interaction partners:
- Sphingosine 1-phosphate receptor 1
- T-cell surface glycoprotein CD4
- Killer cell lectin-like receptor subfamily B member 1
- T-cell surface glycoprotein CD8 alpha chain
- Interferon gamma
- Interleukin-2
- T-lymphocyte activation antigen CD80
- L-selectin
- C-C chemokine receptor type 7
- Interleukin-7 receptor subunit alpha
Sequence:
MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATLAVIDSEKDMNFLKRYAGREEHWVGLKKEPGHPWKWSNGKEFNNWFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK
Protein: Photosystem II CP47 reaction center protein (Q8HS55)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Plastid, chloroplast thylakoid membrane {ECO:0000256|RuleBase:RU004535}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU004535}.
Interaction partners:
Sequence:
ALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWNITGGTITNPGLWSYEGVAGAHIVFSGLCFLAAIWHWVYWDLEIFCDERTGKPSLDLPKIFGIHLFLSGVACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQPVNPAWGVEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVSAGLAENQSLSEAWAKIPEKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAVGWLGHPVFRNKEGRELFVRRMPTFFETFPVVLVDGDGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPATVKKYARRAQLGEIFELDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGAFQKLGDPTTKRQAV
Protein: Probable cytochrome P450 12a4, mitochondrial (EC 1.14.-.-) (CYPXIIA4) (Q9VE00)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has a role in resistance to insecticide lufenuron, but no other insecticides.
Subcellular location: Mitochondrion membrane {ECO:0000305}.
Interaction partners:
- Probable cytochrome P450 9f2
Sequence:
MLKVRSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFKFIDLPN
Protein: Ribosomal protein L9 domain-containing protein (Q57UC5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosomal protein L22p/L17e
- AB hydrolase-1 domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Ribosomal protein L11, putative
- Large ribosomal subunit protein uL3m
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MRRTVVQRVAPWVPPPRHDIKVTMPPPPGGEVGGRFGVSQGYSDRLARTPYWKRMALSTYKLRMMENATRYPMSEHRPGEYDIRYLPTPYPCTIRNRPLLEVGEPRQIPSIRIPVIFLVNLFDEAKGCWFGRRYETVYVERQFMREELMPQRYAIYATPEAYKLLGLPVVNHHTHEEIPKTPREYEKLLERQRYDEERWKYTIEYLFRKYEDGPPELLDRPEDGWDGSEEIALSSVAGAGRDGVVSQRKGPVKQRKARKIKLF
Protein: Uncharacterized protein, isoform G (M9PG56)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MATSTASTTATTAGGTGATTGLFATTGAPGSLGRQANVVSSSEFFSVSFCLDSSQQPDEEFIPATKGVTLLNALSHALRRRNLSFTQITITDNNPTPSFLDAGPSLLPVSVDEQTDVESLAGHHLCITERGSNRKPLQKAASFGSRQPPPRLLPSVSTEETSESGVAPGKQIKQRWSSIFGIKNPQQSQLCELLNSYAKNGVPQRPDSMSFDHPDLVNSLAYLQYMHKSWRDFVNSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGDHKFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQLAPNNTLNCVYLNEFQVATTAFTLQCTEAKNWYDALWRAKTIYQRLKRGGGGGGSGSGTVGGGDSFRFGGSATSGGTADSLGVRKSPMNSSICSHVSSANNSHSGSVEWNDSRNISVDFEKTNSVSSDEGSSIMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSANTLSVQPMNHLGQSLPNLNMHHSHTVPLRRGMAFSTSTKNPPLRKTRNITSQNSINWHQIPATPTPPSPRSQYQSPGVVCMQKSLPLLLPTNTDEGQGPTQPPPPLQKQLSHQAPLPTTIHNQSSTETDV
Protein: TGF-beta activated kinase 1/MAP3K7 binding protein 1 (A0A0U1RRU5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase kinase kinase 7
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- TGF-beta activated kinase 1
- TNF receptor-associated factor 6
- NF-kappa-B essential modulator
- E3 ubiquitin-protein ligase XIAP
- Interleukin-1 receptor-associated kinase 1
- Toll-like receptor 3
- Inhibitor of nuclear factor kappa-B kinase subunit beta
Sequence:
MFNAYEHDVLRRSLPQRLWDQIVLSRAARRTSIEQQPSWTDDLPLCHFSGVGSASNRSYSADGKGTESHPPEDNWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNTEHTDADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLLPQYQKILERLKALEKEISGGAMAVVAVLLNNKLYVANVGTNRALLCRSTVDGLQVTQLNVDHTAENEDELFRLSQLGLDAGKIKQVGVICGQESTRRIGDYKVKYGYTDIDLLSTAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEVAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERAKFCPRHEDMTLLVRNFGYPLGEMSQPTPTPAPGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNGSHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVMTAP
Protein: G-protein coupled receptors family 3 profile domain-containing protein (A1IMB8)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Neuropeptide receptor 18
Sequence:
MTCVSFHTPPLLRRYSSILQNLFFFFLLHIPISSTVKQLTVPGQIVLGGLFPIHEAGRNASHQCGKIKADQGVQRMVAMLFALEKVNRDRQLLPQASLGAQILDTCSVDSYALEQTLEFIKSVMSNGDGVTCADGSTGSYTRQPVVAVVGAAGSQVSVMVASMLQLFKIPQVSYSSTGAELSEKPRFAFFSRVVPPDNLQAQVMARVIGALEWTYVHAIADTGSYGERGMDSFRAAAAENGICIDGDVQKISRRWTEKNFRDLLIRMHRTRKARGVVMFVDEDNLKRLLKTLDLLVAEGHTELDRHFWFVASDSWGIKQSVVRGLEHRTYGAITIAPMVREETGYLEYFRSLSPKGFVFLEEFFEYLGCSATVDVKTFGDCFDMVNITLKQESYVPFVVDTVKIIAKAISMYIEDDCGKIPFHKCTLAQSGFRGERLQRYYRNMSLIKNEPALIDANGDGIGRYDVFQLDINGVYQKVGKWRSTDDFLSVEVEKIRHAFKTAHGERPMSVCSTDCPRGHYRAYQDQTCCWACIPCDTSTSIHNETSCEECAVGMVPDRTLHFCVPIPPVSMQWDTTWSLIPAAFSTLGIASTIFVVSVFLKFSNTPVIMASGRELCYCMMSGIGMCYTLTFFLVSQPTVITCSMTRILMGLSMSAIYAAIITKTNRLARVFKPDSAQRPRFITPKAQVGICMGIVSVQLIGTFVWILFDPPGTMIVFPTRTEAVLTCKATTSHLLISLLYNILLIVACTVYAFKTRKIPENFNETRHIGFTMYSTCILWLAFGPIYFATQSDFRIQITSLCMCISLSGTVALICFFAPKVYIVLFQPYKNVRTRQSAVGRLVNQQMRFMSQLTYNPDGCNSYQPMSSNQSYKPSISAEESSHTSNAQVQQPTRAIPPHVIEQLAASLPISDKNDLVKKLSLQDKFFNNNNNNENSEEIRRRRPSSVHTVGAVTNGSSVAHIPPRSYTDEPKSSMIRQDTAKSRTSLAESHQVDLILEEIAADTNSTFL
Protein: Major sperm protein 77/79 (MSP) (Q9TVW5)
Organism: Caenorhabditis elegans
Function: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Subcellular location: Cell projection, pseudopodium. Cytoplasm, cytoskeleton.
Interaction partners:
- Major sperm protein 55/57
- Major sperm protein 33
- Major sperm protein 152
- Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142
- Major sperm protein 10/36/56/76
- Major sperm protein 49
- Sperm-Specific family, class Q
- Sperm-Specific family, class Q
- Sperm-Specific family, class Q
- Sperm-specific class P protein 34
Sequence:
MAQSVPPGDIQTQPGTKIVFNAPYDDKHTYHIKVINSSARRIGYGIKTTNMKRLGVDPPCGVLDPKEAVLLAVSCDAFAFGQEDTNNDRITVEWTNTPDGAAKQFRREWFQGDGMARRKNLPIEYNP
Protein: Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) (O60336)
Organism: Homo sapiens (Human)
Function: Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22700971, ECO:0000269|PubMed:28089251}. Nucleus {ECO:0000269|PubMed:22700971}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28089251}. Note=Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells. {ECO:0000269|PubMed:28089251}.
Interaction partners:
Sequence:
MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPGPALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGFLDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKHGQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPSDNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSESTEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGAAPGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVHSLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISRSISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGRAPGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQGPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSVAGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSELLLRAVERRMERKL
Protein: Lipophorin receptor 2, isoform D (RE61404p) (Q6NN57)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MATTCMPHFTEYFQTTTQSELTTNESANSRSSSSSSGCREPSKTSGFFYSASTHYQSKVQQLISFSFTSSFHLLFITCILSISKFCNAAAVNAAHVTAATPTASEIMHNLSGSALLERLKASTLGPTLDQLKHLAPAAANSISPGTGSGMGIGMGHFGSSINSVLNGNPLKFLNVSGKIGTPLDISLGLSNYCDEKQFQCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDRENDCADGSDESTSQCLETKTGNNRTDTSNQVHKSDAESENDYVEIALHVIASLAGTALVASVIYVVYRRCTRAVNSMNFENPVYHKTTEDHFSLEKNGTPHIYAAANDEEAVNPLFKSGTECV
Protein: Myosin VIIA (Q9DGG9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVILQQGDYVWLDLKTGHEFEVPIGAVVKLCDSGQIQVLDDEGNEHWISPQNATNIKPMHPTSIHGVEDMIRLGDLNEAGILRNLLIRYREHLIYTYTGSILVAVNPYQLLPIYTADQIRLYTNKKIGEMPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQARDERNYHIFYCMLKGMTPDQKKQLGLSKATDYTYLTIGNCTVCDGRDDQKEYSNIRSAMKVLMFTDKENWEISKLLAAILHMGNLRYEARTYDNLDACEVVRCSALTTAAVLLEVDLKDLMNCLTSRTIITRGETVSTPLSTEQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSLELKAVRRSIGLLDIFGFENFMVNSFEQLCINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESKFPKGTDTTMLNKLNSQHKLNTNYIPPKNTYETQFGIQHFAGVVYYETRGFLEKNRDTLHGDIIQLVHSSKNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQEDLRGTCQRIAEAVLGRDDDWQMGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKDRSNFLKMKKSAMLIQKTWRGYYCRKNYGAMRGGFSRLQALYRSRKLYQTYHVARQRIMLFQGRCRGFLVRRAFRHRLWAVITIQAYTRGMIARRLYKRLKGEYRRRLEAEKLRLAEEQKLRNQMSARKAKEEAEKMHQERLAQLAREDAEREKKERQEARRKMEMLDQMEKARQEPVNDSDMVDKMFGFLGTTNSFPGQEGQAPAGFEDLERTHRELEVEDLDESLPLPEDDLEDLSEYKFAKFSATYFQGTSTHTYMRRPLKQPLLFHEDEGDQLAALAVWITVLRFMGDLPEPKYHTAISDGSEKIPVMTKIYETLGKKTYKRELQALQGEGENTHIESHKKSSVRHKLVSLTLKKKSKITEEVTKRLNDGEYTVHGNSMLEDRPTSNLEKLHFIIGNGILRPGLRDEIYCQICKQLNQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFISEGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALSDKISLQDRFGFSLYIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFFRKEIFTPWHDPAEDAVATNLIYQQIVRGVKFGEYRCDREDLAELASQQYYVDYGSEILVERLLSLIPSYIPDREISSAKTVERWAQFIMAAHKKGVYTQKRVDPQKVKEEVVDFARYKWPLLFSRFYEAFKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEITAVSSSKGGKLQAQSFTLATIKADEFTFTSNNAEDIRDLVVTFLEGLRKRSKFVVALQDNPSPAADDSTFLSFLKGDLIVLDQDTGEQVMTSGWAHGTNDRTKQRGDFPADCVYVLPTVVRPPHDVVAFVTMTPDQRQESLRISHVPALTETEERVKPYTLEEFSYDYFRPPPKHTLSRVMITKNRGKDKLWCCTREPIKQALLKKCGGHEELSQEACMAFIAVMKYMGDYPSKRTRSVNELTDQIFEGALKAEPLKDEIYCQILKQLTENHIKYSEEKGWELLWLCVGLFPPSNVLLPHVQRFLQSKKHHPLALDCMQRLQKALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCLNISSRLLLKTPEGFSLFVKISDKVISVPEGDFFLDFVRHLTDWIKKARPAKDGIVPSLTYQVFFMKKLWTTTVPGKDSFADSIFHYYQELPKYLRGYHKCSREEVFQLGALIYRVKFEDDKSHFPSIPKMLKEMIPQDLIRQLSPDDWKRSIVAYFNRHAGKSREEAKLMFLKIIFKWPTFGSAFFEVKQTTEPHFPEILLIAINKYGVSLIDPKNKDILTTYPFTKISNWSSGNTYFHITIGNLVQGSKLLCETSLGYKMDDLLTSYISQMLTTMSKQRNSRGGSSK
Protein: Alanine-tRNA ligase (At2g45060/T14P1.13) (Q94AZ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA ligase-like protein
- Thioredoxin superfamily protein
- Protein ABIL2
Sequence:
MAALGESSSSEMDNAKSPEIQQSSPVHPPEYQKIATTTVENAASWIDDALRQALVYQKTITETVDSTIDASKARLSQIRDTSVAHTSQTIDSLRDIASEYNVYEQMVFGKIKDGVNVAASHPLISGTLAFGVGIFALKKTRRFVYYNTVRMFVSEEALLSRADLKVKELRQSMDRLKAESEKLERVATVAEEEFIRGRMKLRQAGKQIRGAISSAYKIEKQAAGLKDVLKELPTREASRFRTQISKRASEVKQERNALTKEVNKISNYGISV
Protein: Protein Wnt-4 (Q9QXQ5)
Organism: Rattus norvegicus (Rat)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development. Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary. Required for normal lung development and for normal patterning of trachael cartilage rings.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Frizzled-3
- Frizzled-6
- Frizzled-4
- Protein-serine O-palmitoleoyltransferase porcupine
- Frizzled-1
- Frizzled-2
- NOTUM, palmitoleoyl-protein carboxylesterase
- Glypican-3
- Frizzled-9
- Frizzled-8
Sequence:
MSPRSCLRSLRLLVFAVFSAAASNWLYLAKLSSVGSISEEETCEKLKGLIQRQVQMCKRNLEVMDSVRHGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGDLEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAHVELAERCGCRFHWCCFVKCRQCQRLVEMHTCR
Protein: Transcription factor lin-26 (Abnormal cell lineage protein 26) (Q27355)
Organism: Caenorhabditis elegans
Function: Probable transcription factor. Required to specify the fates of hypodermal and neuron-associated support cells. Functions during vulval development, playing a role in vulval precursor cell fate specification. Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor elt-1
Sequence:
MILHGFHLSTSSHCLPFIFRHLFIFHSITALCDHVISNYCNSLKLSNNKFNQMLSKFVVVEVSNSNNTMTLVEYLVTHGFDKFAVVTDLVDHPSFKYKDGSSSPESPSTTASTAAQHTPPRTAVSTPTSINTPVPPHQNKQRHSIDKIAANLSTKKVSPSSIEKQLQRTSHNPLHQLSTPHALSQLQKLLEEQHKINQMNIQKKEQERQQAEIQRILLQQANAAQINHSFGLERLTPEYDDNHHSETISKASSEDLKTEPDSTDFGLGTSDDQVRASMLHLLHPVFAPAFGMLDAENIFGAASKPTTPASKRRNTDSNGAPSKKHRWLPVNELEESRSSRGKNCGRVHCKATYKCALCGKPTTLNSTGSRWNLLRHVIMIHSDCKPYKCWDCDFTGIKSNVISHARQCRHNAEDAHDITTDEMRAEWNLRLHECFPDYVRAKERGWQPEEVTVKKEEVEESPTLVKQELTLVKQEPTFAEQLEPMAQPLV
Protein: Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2) (Beta4GalNAcT-2) (GalNAcT-2) (Q8C1F4)
Organism: Mus musculus (Mouse)
Function: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains (By similarity).
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
- Chondroitin sulfate synthase 2
- Chondroitin sulfate synthase 1
- Hexosyltransferase
- Chondroitin sulfate synthase 3
- Chondroitin sulfate N-acetylgalactosaminyltransferase 1
- Carbohydrate sulfotransferase 12
- Carbohydrate sulfotransferase 7
- Carbohydrate sulfotransferase 11
Sequence:
MSRRGSILHSRTQWLLLGLALLFSLVLFMYLLECAPQTDGNASLPGVVRENYGKEYYQALLQEQEEHYQTRATSLKRQIAQLKQELQDMSEKMRALQERKKLGANGVGYPGNREQAPSDLLEFLHSQIDRAEVSVGAKLPSEYGVVPFESFTLMKVFQLEMGLTRHPEEKPVRKDKRDELVEVIEAGVEVINNPDEDDAQEDEEGPLGEKLIFNENDFIEGYYRTERDKGTQYELFFKKADLMEYRHVTLFRPFGPLMKVKNELIDITRSVINIIVPLAERTEAFSQFMQNFRDVCIHQDKRIHLTVVYFGKEGLSKVKSILESVSSESDFHNYTLVSLDEEFNRGRGLNVGARAWDKGEVLMFFCDVDIYFSAEFLNSCRLNAEPGKKVFYPVVFSLYNPAIVYANQDVPPPVEQQLVHKKDSGFWRDFGFGMTCQYQSDFLSVGGFDMEVKGWGGEDVHLYRKYLHGDLIVIRTPVPGLFHLWHEKHCADELTPEQYRMCIQSKAMNEASHSHLGMMVFREEIEMHLRKQAYRTNSETAG
Protein: Fused isobutyryl-CoA mutase [Includes: Isobutyryl-CoA mutase (ICM) (EC 5.4.99.13); P-loop GTPase (EC 3.6.5.-) (G-protein chaperone)] (Q146L7)
Organism: Paraburkholderia xenovorans (strain LB400)
Function: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly (By similarity). Does not exhibit methylmalonyl-CoA mutase (MCM) activity.
Interaction partners:
- Acetyl-CoA hydrolase
- Acetyl-CoA hydrolase
- Acetyl-CoA hydrolase
- Urea amidolyase-related protein
- Oxidoreductase
- Oxidoreductase
- Oxidoreductase
- Indolepyruvate ferredoxin oxidoreductase alpha and beta subunits
- Succinate--CoA ligase subunit beta
- Acetoin dehydrogenase
Sequence:
MTDLSTPQRAGSHKLPAGRRLRFVTAAALFDGHDASINIMRRILQASGVEVIHLGHNRSVDEVATAALHEDADGVAVSSYQGGHNEYFRYLVDLLRARGGERIKVFGGGGGVIVPEEIAGLERYGVEKIYSPQDGQRLGLQGMIDDMIARCAEGARAAAATGESQVGAWAAEFSEHGLPRFDSRDDVGVDRQGAVARNPSSEASRVAAAGRGDHLDRGVRAASTADTADTANTANTANTANTGSVADAADAADAADAADAADAASTASTASTASTASTASTAGIPDPASLVFRRLAQLISAFETAAIDVNTRDKLSALAEVTAIPLLGITGTGGAGKSSLTDELIRRFRLDYGDALTIAVLAIDPSRRKSGGALLGDRIRMNAIGDWGGGARVYMRSMATREASSEISDSLPDALMLCKAAGFDLIVVETSGIGQGNAAIVPFVDESLYVMTPEFGAASQLEKIDMLDFASFVAINKFDRKGARDALRDVAKQVQRNRADFAKSPEAMPVFGTIASRFNDDGVTALYRHVAEALRKHGLRSGGGRLAAPEDLRFSSGRNAIVPPARVRYLADIAQTIHAYRERADAQARLARERWQLIEARRMLVETGEAARSTVATSASPGASASSKANACTSTSSKANASPGANTTANSNASATSGTATPTDALNPTLSQLDTLITQRTASLGERERILLDTWPEIVAAYSGTEHIVRVRDREIRTALTVATLSGSEVRKVSLPKFVDHGEILRWLMLDNLPGYFPFTAGVFPFRRENEDPTRMFAGEGDPQRTNRRFKLLSEGMPAKRLSTAFDSVTLYGEEPHERPDIYGKVGNSGVSVATLDDMKTLYDGFDLCAPETSVSMTINGPAPTILAMFFNVAIDQQIARTTQRQGRPLTEDELAATRRTALENVRGTVQADILKEDQGQNTCIFSTEFSLKVMGDIQAYFVEHGVRNFYSVSISGYHIAEAGANPISQLAYTLANGFTYVEAYLARGMSIDDFAPNLSFFFSNGMDPEYTVLGRVARRIWAVAMRERYGANERSQKLKYHVQTSGRSLHAQEIDFNDIRTTLQALIAIYDNCNSLHTNAFDEAITTPTEESVRRAVAIQLIINREWGLAKNQNPNQGSFVIEELTDLVEEAVLAEFDRLTERGGVLGAMETGYQRGRIQDESMLYEHRKHDGSYPIVGVNTFLSAHPHEAPQPIALARSTDDEKQSQLQRLRAFQAQHRDAAPAALERLKRAVIDDENVFAVLMDVVRVCSLGQITHALFEVGGQYRRNM
Protein: Pyridoxal kinase (EC 2.7.1.35) (Protein SALT OVERLY SENSITIVE 4) (Pyridoxal kinase-like protein SOS4) (Pyridoxine kinase) [Cleaved into: Pyridoxal kinase, N-terminally processed] (Q8W1X2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the transfer of a phosphate group from ATP to the 5-hydroxylmethyl group of pyridoxal to form the biologically active pyridoxal phosphate, an active form of vitamin B6. Required for Na(+) and K(+) homeostasis and for salt tolerance. Involved in root hair development, both for initiation and tip growth.
Interaction partners:
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
- Probable pyridoxal 5'-phosphate synthase subunit PDX2
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 2
- Pyridoxal 5'-phosphate synthase-like subunit PDX1.2
- Pyridoxal 5'-phosphate synthase subunit PDX1.1
- Pyridoxal 5'-phosphate synthase subunit PDX1.3
- Pyridoxal reductase, chloroplastic
- Thiamine phosphate phosphatase-like protein
- Inorganic pyrophosphatase 1
- Inorganic pyrophosphatase 2
Sequence:
MTTPPVLSLALPSDTGRVLSIQSHTVQGYVGNKSAVFPLQLLGYDVDPINSVQFSNHTGYPTFKGQVLNGQQLCDLIEGLEANDLLFYTHVLTGYIGSVSFLDTILEVINKLRSVNPNLTYVCDPVMGDEGKLYVPEELVHVYREKVVPLASMLTPNQFEAEKLTGLRINSEEDGREACAILHAAGPSKVVITSITIGGILLLIGSHQKEKGLKPEQFKILIHKIPAYFTGTGDLMTALLLGWSNKYPDNLDKAAELAVSTLQALLRRTLDDYKRAGYDPTSSSLEIRLIQSQEDIRNPKVELKAERYS