Protein: Guanylate cyclase alpha (PfGCalpha) (EC 4.6.1.2) (Guanylyl cyclase) (Q8IHY1)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Catalyzes the synthesis of the second messenger cGMP from GTP (Probable). In asexual blood stage schizonts, required for cGMP production which is essential for PKG activation, PKG-dependent Ca(2+) release, and ultimately merozoite egress from host erythrocytes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10747978}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:33500341}; Multi-pass membrane protein {ECO:0000255}. Note=In gametocytes, localizes to the cell membrane and/or the parasitophorous vacuole membrane. {ECO:0000269|PubMed:10747978}.
Interaction partners:
- LEM3/CDC50 family protein, putative
Sequence:
MSDSKKHYNESNVRYKVKYSGKIFGNNMKKLNENNNHDFTTAEAAWMEKKKKLYKDTNNQPLWDFRKIQINPTETDELISFPSNKICSKNYGKYSFIFKGLYEQFLRLPNIWFLLISLLEFIPQYQNLSNYMYYSKHSSFFLLLFFICVSIIKNIYEDSRRSNIDYQINNRLCHMLDGPNSQLKAVRWMELSVGSIIRLIENEQVPADILLLSCNNSEGVVYIETSLLNGETNLNKKYCVNETRNETSIYAISNIRGRIVCEKPNSNMESFNGSLKLDAHPRATSLSINNVIFKGSHIKNTEYIFGVILYTGNDTKIMKNISNNKHKLGYVNKELNSYTIIGLIFTFICVFISVLFKWTEDDKFRNGSHFFLITVKDNICESIVKYTLLYSNIIPISILISVDLISILQSILIENDNHISTFENYETSEPSTIDDMDNELGDFKMDKSHTFFKKYTYFLNNRSKNFTNNRYSSTNTERASDFRKSFFGTFDKLKTIKRYFYSIKSKIKSISQSNTLYNKSSAGGSIIRSDKNKQTTFSKSFIDIFQRTNNNEHSQTLDNNNNNDNNNNNNICKEKYQNVNNSKNVYVSEDSSNNKYKQNDYLQKSQEQNEIHSINNNNYNNKNDNNLQTEFSNHNFRINAYKTNRTTKDDTYNNKHISLNSRSKSNQKGILINSNEINRKKKKNLLQKIFPFFKKKRTNISEDLSKYVFRRSKQLNINHNNSEKYNLNDYDEYGWGLCLNSNMHGDLGNVDFIFTDKTGTLTNNNMTFNMCSIAGKTYGSKCKNKKKIYNNPKSNNDNKLNSYDKNIFKNKFSSEASIKKISFVRDFSNNVSSKNDLTLDDPTELISDEGNNYLRDKYEHTSDKKNDTNKNRDGANNSNNNNNKDVSNNKNKNNNNYNYNSNNDYIKQNGECNIYNNQNNTNNTHNNNIYYDEYNNTNEGNMKNTNVNKDTNSKCNKKDFIINTSDIINNNNNNNNDQKTNNLKYKSSSSWNSKAKKSSYINLNSYNKYQSFQNSSMLSSSLSSTCSSETEDENGSQLMYYSSSNYDNLDINNDMDSTKTYSHYTEQNYYNSVKDDKDINSEHQRYQQKKTNKQTKNIQQNQCDQWEDNRYTQESIKNQYFFDRNYQTFLMKQNFPRPKSFRLNMNSSSVKGRCDFNDTKIYNDLNSQSWRGYYIDEFFKCMTLCHAVTPFIQFDYIRNKHLTYTNSRSSKGISNNMDRYNINPTTTTTNNNNNNNNINNINNINNNNNNNNNNNNNKQFSCDYMKNRNDIIFETSTDYYANQDNAKRKREKTLFDNVSHCGEIQEYRDNKKYRMKRSQTCSNNRKIFSNQRTLYDYRNMNNNLKNKNSYLRNKLKSKIFLDKSYRKRKKSSGTYKGSDICKGIEKKETRRWKRFLHMKGSNNRNIFSRIKDFKSNSIIYNNQDKTNDYKNGYSNNINNNNSNNYTNEKINRSFNKRHSAVSFKQMSKEKLIPINNVLSNRCDVESYPNEELSFSKKKKKNSEIVSFASGKSDIGFEERTDAGIAGKNMELSYNELEKYKYVKHIDSNNKYINNNNNSIHMSHMSSNNNTFESHIYFDAIKYQSSSLDEECLIYSSSFLGYRLVLRNKNTMCIEIDGSFNKWTIIGVNEFTNRRGKMSIVVKPDSMESGSILYVKGSDSSILSLLNLKYSKFLDKKYSRKRRNKNIQKYKQKREEYNELKSKDINIEEFQKSKSLSLKNFKNNTPKVLFGECTLDNNNNNINKNYKYDKNDKHNNNNNNNNNNSNYSYNYLHDSNNLDAMQNQKYSYAYEDKEDYYYTNNGECNKYKERYRRLEKQLRKFSVKGLRSMIFAFRYLSEEETIKYKRMYDDACSSIYNKEQRLEKVAEEFERDLIYLGITGVKNGLQEKVPKTIDILNQSGIRIWMLTGDNVEYSLHVSFLCKFLNKHTKIFHAALENSNAKKLKREGMALYELFQLEKEEKKPYENLCLLVNGRNLQTFLNYTDLQTHFLNMACTCDVVIACRITAKQKAFLVQLIKNRLYPTPNTLAIGDGANDIAMIQEANIGVSIMTSDCIISAGYSDYCIKKFCYLRKLLFIYGSKHLYTISIILYWNFFKNILLILPIFFYQAYASWSCVKIYPELLYTFFSIFWVFIPIIYYMFLQHNLNYDILYNIPLFYALSRRRYNMNCFKFLPWIFEAIFYSMIIYFFAYAALKENSHLNNGEVITINTFGNICFIGCLLISILRLFLEGSLWSPSILITCFGCFLFVFFPSLLFICFAYLSNEYIREVFRQTFLWAPLYVLLILWFSTCIISYIFINFTKSILFPNIYNVVNHWLFEQYQEKHNKNKYIFSLSGKNKFLKLRKLGKKIKFKFKRNYSKKYDTNVIREHPLLHHTFKSEQDQNKCNEQFSKDPFISNSLLKSKNCKFKKDSSYSKSNIHVDEEQTYKGLKVVLSEQVVHAKENLVSFKNEKKNKNNKNTSMNVNDNIIIKNNNINIKNNDNNNDDNDNDNNNNNNNNDNYNNNDHNKKEFKQKHIQNNYENLFNHTQVENNLIKENLSIRNDNNRRDNKNETDYIKQSDEDYEMNPSITSLRKRECINDSKYIDNKSYDNKISNNHEEKDGFKSDDRSLINSNMMDYKNEFTENDTTYSFNDSHMFYDFPSNSKTTKDYKVINSRIDDSIMADMKNCLNPLKNTFLVDLLPPGKRFRINEDHIYFKNNERMENIPEALDVNKKYYHIIQNKAEYYDNDSLSEFSYTSSNSSINNKKKNENTQKEIVKVSHLINRFTLAFKDMQLESGFQIHKKNKFYKTFTPWYRFIFLLLGVFFLYVWKLESSLSQLWNMPSDASTDVFILFLSLLLELVLLAATVTTFFSNIFIENFNKIISAVVILIITYHVVSYSVTHIDGVFQAVLFPLYTFVILRLPFVNAVLCNIIFLGLFIIRFNGDHFLDKKGLAHYIPLFIGVDVFVGFVGYRLEYNQRKNFLLEYSVESSRRKQREILNTMLPPFVVDEMIYSELNEEGIPISLKAEDISTVTIIFCDIYDFQNIVASIEPTRLVEVLDRLFLCFDKCTEQFNCTKIETVFETYLAACGLVKREKDEDELENNKYSNNNKNNNNNYYYNRKKKKKKNNNNNNNNNNNNNNNNNNNNNLNNNNNNNNVNTSDDDGDFFEEDDANNHQIYNQMKGQEDAHDSIDFALSILHVSSHIKYEKSKMMLKKNDSFEDANDDTHNVNDSFNNDKAENDNTNTDNNKPTRIRVKVGIHSGRIIAGVVGSKKPQYALFGDTVNTASRMKTTGKPDYIHISEATYNLVKDDKTLIYEKKETEIKGKGIMTTYLLTSVIGLNYPFLGEHVEKKGHFISELYEDDLSNNLNYDKTQNILGYYSNKINQNNDSNINEGIINNNMNTFNTIDGDTSNYYVNLKDLSLNDLPNEYIKDVNTHYCEIIKLRNLKIGTAVGYQLKQKDFYNMTFLNNGLNNDTATNFNQYIESHKDFDDIKDLRIGMNKLSISDSLYYLNENVIRNEPINEYKNKIKINSVNTNKKSYEDAHLNAGNIIYTNNEYPNGQNIEEDDDLLLTNHYNKTNVNNNNNNNIYDVSKELIEHNEEDYKNILMCSKRCKNCNETYCTPNDCNNNDHVYHVMYHRKLSNIKKNYLKNIRKDANIKKDIEKEELNKIHSNKKSFNFFYLFSYIFKIFPFIGKINKEEKKNKSYKKGEQDKSSKRIIALNSEWIFLKFSDKNLEAKYRAHFYSNKSNINSIEQALIIFLVTFVMQTLISSTVSIVFIDHKRATQTLHINYFAYWSVRSVYTFFGFVLWLLFHYRTRPEVSSLLNIKWMIFFLNLLFISAACVFSIAYLWAISETDQTTSYTIWMTNDTIEFFFYLVILHHNTGMLFQTCILVDLLFITMSLTFIATSVVKTITTDSTVLLIPWYVAFNLISTYCKESIDRRTFYANESAKKTENRATELLNDMLPKHVLEEFQQDKLKLAYTHDRLTFLFADICGFTSWANGVDASEVLTLLQKLFAKFDNDSTKYGLYKLCTIGDAYVAISEPVTEDNKDYDPVDGTERVLEMAYSMIRIIKEIREKLYIPNLNMRIGLHYGSCVGGVIGSGRLRYDLWGIDVLTGNLMESNGIPGKINVSETLKNFLLQQFKNRFIFKPHTTIRVIYKDVKCFIITDKKEVESSNHSKLLQNKNYLLNKKFSTQNYLVKNIFAKKKHSSISSSKNIHSYDEKKKKKNDLFYINVNDRQSNL