Protein: Putative dynein heavy chain, cytosolic (Q4QBN6)
Organism: Leishmania major
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Tubulin alpha chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Cytoplasmic dynein 2 heavy chain 1
- Cytoplasmic dynein 2 heavy chain 1
- Ras-related protein Rab-7b
- Cytoplasmic dynein 2 light intermediate chain 1
- Putative 3-oxoacyl-
Sequence:
MFPFDDNVVQFIVLLTQHGTVEKVRAAIAQSADAMGFASPPASPESAMHLAAVQQQNIGERDRGDDRETGVVSKTALLGAHVPLIAICEISDGCAVTDGSQIIATADPATFFRSVSCMEDATPEEAVSLGAPACGGTGARRSTGSGPGDDSVPGARHKAKALSCILLERRDPHGAGGGTAGGGGARALSVRDLYIQSMDLQRPLHTLQSILRNIYDPMLRSHKTQSALRSHVQDLLSSIRSMHNVLPEIDVTRYVHEDLLQLCDANPLLDVPQLIDRLGEVAKDPSFIRRVLQARNRCREALSMEPLLSGKLEEEELAKELQSTNSKAIGAPAVGPTGLPSGWSGVHPQPSAFATPLPGAAAGIAYDGDGGDDSARVVQERIVYWRCVHAWMEDILRQLRGREWRLVHRLLAQRVETDYVGEYVGYLKLVQEYITFLNTIPEKRLVNVQDMKEFNDVTDEIIMAATQPTRFAARLQLSLLTSLVWQISSRWVSVMETQQVLSLDEDPNVAPVAAAGDANATQHSADVTAGAHADPFVHLQTLRIAIHSLRTLQARYVEHSTQLRHQIRVVRSPREHVEHPRVEALLARCLAVRDLIEEHLLLMRQLGVVFSTKIRLQFARAKRDAVPAMGVVAAQQQPGEEYALVMQDAFNECVRAVGGWVDDAEDLQRSRKGSVGEPAASSGSPHRGCKRCSNYLWQTSPTAVQRFNAAVQEYQHKRSQCDEQIALVVSQLLSNQQYAHSDGRSSMGGAGAVGMAGAGAALKGPQASVNYADNHGLRLFRTFKRFKMLPLERVQRVVHSYQDAVAEKLSAYVGYVQDCYVNVPLTKKEVSYNMARFSVSALVAQIMWEQRLAEALTKSMMRFDYVSEHGWHQLLYLRNVEHYWRLNASLAEFIGVPLDLLVCDELQLDSEVHGCAVALACLSLHYTEEASEWEQDEHLRIAQDLVATCDPGALAVARDRMLIGGAPRLYKTTARARDIRSSRDIIQQRIESHMASWFEEVDKLIGGSGLDQQTLLLSGPVLWAVNCGPFSGPHNTTGGAVANEADSAVMRLQPSGGAGAMTGGFTANANYFNTGGAGSMPRASSFSPSSLALLRAQGRSASPSVRRASFLVPVGSGDSESLAPAAATAASWMVEVAFPWSFPNIAEDLRYLESSYLTSTLLSAGSGEPAATSRNSSSAAGTTLSPRGRCPAVASDLAFLRDALRGNELRSRLAHTLVELIHVYYVTVKGEDTSLVLLATDEYQEVNRLFQMGIALRWSDEGLLSYVQQLSDTMQAFTTTVQQLRSKTELVYRKIRAFLVRAFHPEAILQRVKALRRIVDTLALRCVHAHLWTRQIQPLLEQALLTQMKYLMHSFTEDFLSMRSDVRFLEKGAETDVFRLTPLRVRMRVVYKEVRLESCCGAWRQHWISELNRFFSWIDVLPRLYKEEETQADVVGVPAALGSDMTSTAVTHGSNSTDGAGVNAGIGRAGNNGHNAASGRAPDDGYQYLLLRLPASALAEPLHAIEQCVQDAIDTENEWRRGQQFLSMDVALMQQRFGRDLRRWSHALRLMHTVTSRIMDYTQPNKLLGGIVILAQEAQIELGRKLDQVSQYAHAKFKDLLQGEQERAFSVITQEQMKIDALDVISNAKDAAAFLSEAPRLKSELQKLDGEITLMDNGEVSLQKLGHVFPENWMYAAALREEYTSLAELVDRKLKAVQVRRPFLIEEAKSAASALEVKVAEVDARFHNVDSIAVSKEAPVLAKQMVSDIYDEAVAFSVEAKQVTAIQEALGESPHVFASLQKLLADVARVKDVWGHVASAYVELNELGAVPFFEMVPRRLHERLQQIDEETDAYQETMQSYQLYQNLKQKLCRVLSYNRLMQDLRSDAMSPLERSMRHWKTLQHKLRAPWVLASLTVANIWESDPGVNAAVYSEVVETAQGERRIEVQLHNINNYWNMFEFSVVVYKKHVALIRGWDEVFERLTEDLSTFGGMRASPYFVFPQLVSMANDAEARLDRLRQVLEVLLEVQKRWVYLDGILSENAEVRVQLPHDTVKFDRTSRELLHILPRPRSSGNLPELHVSFFLEDEKLKATLERLLSQLSAVQRALTSYLDTQRSRFPRFFFAGDDDLLEIMGNSKNPLFLNKHLKKMFTALASLQLDGNVKDATTRLCGFSSAEGEELSFQPGPIAYRQRPIHEWLGEAEQGMVHTLREATLRAYNELVSTKDASPYALLWSMDWMRQKPTQVVCLALQLLWTREQESLLTGAHGGGAGATDARRTSQASSSTLSVVTSSMDDLLTRLAGNVLGNAVAPSSRRQCEQLITVAVYQRDVSRTLAARKVASRDDFNWLSVLRLYVVPIHHQQQHGGKSMSSLSNIGLARGTNVSGLVLSEYRSAETLECRMADASVLHGFEYIGAYERLVQTPLTDKCYLTLMQSLHTRLGGSPVGPAGTGKTETVKALGMQLGRHVLVFNCDDTFDYQAVSRIFLGLCQVGAWGCFDEFNRLEERILSALSLQIQVIQHSLRAWQREVQLNHRAVPLHSNVAIFITMNPGYAGRSKLPGNLKQLFRTVTMTIPDRETIAEVMLFAQGFTTAEALSQKVVPLFRLCEEQFTRQAHYDFGLRALKSVLVAAGDRKRQVAAASRGSPGGHNAAGGAGADTVQETERTLLLESIIATVAPKLVAQDAALFYPLLHDFFPGCSLPALPMDELREAVECVCAESGLSPAAGWMEKVLQFYHTKMTRHGVMIVGPSGTGKTTAWKVLMAAMVRLQRALHMHAYVLSPKVLSKGELFGTLDVTTREWRDGVFTSILRKIIDAEEQQQIPADLALAGDDDTGHQVVAAQSVGVDNKKRASLKQNVICDGDASAPGAQSSEARKEHWIIFDGDVDPEWVENLNSVLDDNRLLTLPNGERLPLPRSVRIIFEVQDLLYATPATVSRCGMLWLSEGVVPLSGVLAHTYHQLQEHPIVDARGRHLHWGTDHMIGVTGVRSAFYTECLVTGEYGKVYHELVLSSARTSVEEVMAGSLPRHHGRTSSGDEDITALATPKRSSHLCKDATPQSDKAAELDMGDTLYGTTGHGSHAIFTSTSGGGAASTLRRSHPDAERIQELMVSSWAAAFEKDGAVVRGLQLMKSAAFRDVCVMVPSDQQCIQSMVAFLVQGVWRTFETEQQSNGDVFSDAVVKKIAMQVLSYAIFWGLASAMSLENRMKLAQQLGLRPTVDGVAQSMLEVEVCYRTGEWRLIRNRVKEISLLAEQVGANDTVITTVDTCRHEDVLSAWLGAGRSAILCGPPGSGKTMSITAVLSSLPEYEVVFLNFSSGTTVKTIVKALEQHCRVQDTARGLVMAPTSGKQLLLFCDEVNLPALDRYGTQVVVQLLRQLIERNGFYRARDNTWITVEDVQVVGACNPPTDPGRVSLSARFLRWAPVLLVDFPSPESLKTIYTTYCRAILAWNERLSGQVATRLAQAMVKMYRVSQAKFTPIQQPHYLYSPRELSRWSRALYEGILTWDDAVRRQLNVSQLVRLAVHEGLRVFADRLVTAEERAWTDTAIVEAFREFFTDVDDHAFHQPLLYSTLLSRSYTDSPREELRAYVQKKLAAFNEEESLGNLVIYDAMIDHVVRIDRVLRQPLGHLLIAGSSGVGKTALTKLVAWMRGFSTFTLMLHRGYDLDDFEHDLRGVLRRAGCKRERICFLFDESNILQPSFLEYMNALLASGEVPGLFDGDEWSKLMQEVRDAVLASQSYYATSRSAGGAGAAGRAGGSAGGGGEAGRDRDSSALRGGGCKGLDGNDNGNGVTGSQRASVVTGVGVAASAAGDDLVDVHNEAELYHWFLRNVHEYLHVVLTINPSSGEFTSRTVASPALVNRCTIDWFGDWDTTTLQQVCQERIRHLALLPACHGVFAIEVEAKEAVVESLCAIHVATQHINQALRVRYANQGTFVTPRHFTDCVSHFVTIFQEKRKVSSDALVHLHSGLKKLELTAQEVAAQRATLQDNEAEIEASSRRAQAMLERIVSETDVAKREKAAAQDLERQLQDEHAQISEDAQRLSIELAEAEPALREADAALSTVKPEYLREIRAYAMPPPMVKRTLEAVGALMGEKNCEDWDSLKNCIRRDDFLASVRNFRPDDITEPARERVRGMMRDSKFTVEAAYRASKAAGPLMQWVFFQVKYSAIYQRVAPVRSKIEKLIKARDVKLKGLEVAQEEVREKENSLQQLMGEYQNATAQIAELKQRITAISAKCNRAQTVLQQLLDERDRWEKEVHSFDSEARTTLGDCVMSAVFLAYTGFYDEHTRERVLMPRWLACLQRATIPVRKGLSVTEYLSPATQQLAWEEAGLPKDRLNIDNAVIMHRCQRYVLLIDPTDVAAHFVLRYYGAQKITKTSFSRPGYVKQLEMAVRFGYPILMEDAEHLDPAVVPLLNGEVRCHGTRHITRIGPHEVDLAPSFHLFLHTRNPNFQSPPDLAGQVCMVNFTVTLSSLQSQCLHYTLLHERPDVDAKRSNLLKAQGEYQLRLRVLEDKLLTRIAEAEGSLLDNNALIESLTELKEEATCIAGDIADSENSMREIRSVEDMYRPIATVVAQAHFALQRFEELSPYYCYNVRFVLRVLDDALRALPATSTPAADGGLRLQQLTYGIFVLLHRRVVRGMFHEDHLVWALRLAQLRSAMSATGAKSASSAPTAASMVVLPTDSTGGSAVMPEEWEWILSCLRLAGSGVGAAGAGAGLPSTAASRTMTTDSSEDGGASSPITAATTATSLPPVVRQACPALGLQSCQALAFLLTKPAFNEVRETLTTRAPAWEAVLTSATPVATSESALPPECFPRGASRVRRFLLLALILLNTRRDAFIEAVRQLLASYFSPKEMGTAAAAGTDAAAALFTDDLFAPQTNDLADGIMAELSAATPLLMVADTMFDPALRVEELAQRTCTNLSVVAMGSMESIENADAYLAEATKSGGWVLLKNVHLARGYMDKLEKQLHFQRSEGQLHKEFRLFLTAERDRSAAKPSTTATAAAASSKVLPINLIEASVVVVYEAPPGMQSSLLQTYGEYPVVGAAAFDGTDASSVAPSAGAAAASNNTSLQRLYLAAAWLHSVITERILYKPLGWSEAYEYTEVEYQRVVQAVQAWSSAAPAPAAATASSSNASALKVSWDALRTIVATTVYGGKVSNVFDQHILNVFCRRLLRPEMLQDAAQFVSEAAAAGAPPPPIRGRSRAELLQWIHALPGGSSHPAWLALPIGADRMTRARSAIEVVERLSLVQSTLDDELTFAEIDSDAQAAASGALRATRWAAKVQSYCTAWYPILRDALGKLEKHPFVLQAVALHKQETVERASAADVGAAKESGVNRSGASHSGGVSAPLVLAMQREVVAAVELVRHLLTCVRELREVAMEERTPSSVHRGLVEELMKDHVPDVWAAHLRGVHGSAAHSLFVGLWIADVQQRVEHLLELATAAHGGQLAKTPVRLGALFSPGAFLTAFKQHCARAEQVPLEQLVPQVEVDAATGASAGRAPRTTSSALSTTGIPGAPATSAASLAPLRENEVVFTGLTLHSAQVGVAGKCTLRGATTSGAAPALSSAVVLRWRWVRSTDSVATTTALTARLERQTDQQQSILLPFYTTENREALLEVLELPKAPNSGITSGDGDAGVHAWYERGVCVTAWSASE