wanglab/gogpt-training-data huggingface dataset:
Protein: Mitochondrial intermembrane space cysteine motif-containing protein MIX23 (Mitochondrial intermembrane space CX(n)C motif protein of 23 kDa) (P38162)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulator of the mitochondrial protein import machinery that is localized in the mitochondrial intermembrane space (IMS) and facilitates the transport of proteins from the cytosol into the mitochondrial matrix. Not essential for mitochondrial protein import but induced and required when mitochondrial import is compromised. Stimulates or stabilizes the translocation into the mitochondria of proteins such as OXA1, ATP1 and COX12.
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289, ECO:0000269|PubMed:32826315}. Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery. {ECO:0000269|PubMed:22984289, ECO:0000269|PubMed:32826315}.
Interaction partners:
- Uncharacterized glycosyl hydrolase YBR056W
- mRNA-binding protein PUF3
- Cytochrome c oxidase assembly factor 6
- Uncharacterized protein YER187W
Sequence:
MVDNRRTFTAPQSLLETNLTFPNDEPSLTTITVTRERCVDPSLIDSFLRFLRHGSDDIIRQKLNNYRKGSINGKNKCKEFLKQELYPNWQIRNNIISFCEKEAAEMKNETDQQCGNNKKTTAEPLIDARIDPYAARERAEKQEAQYKDWTKVTEWVANNRKIEQILTSTTEGILRQNCEQNNDYLKEFTQFCKDNS
Protein: Chagasin (Cysteine protease inhibitor) (Q966X9)
Organism: Trypanosoma cruzi
Function: Cysteine protease inhibitor. Inhibits cysteine protease cruzipain.
Subcellular location: Flagellar pocket {ECO:0000269|PubMed:11719560}. Cytoplasmic vesicle {ECO:0000269|PubMed:11719560}. Cell surface {ECO:0000269|PubMed:11719560}. Note=Flagellar pocket and cytoplasmic vesicles of trypomastigotes and to the cell surface of amastigotes.
Interaction partners:
Sequence:
MSHKVTKAHNGATLTVAVGELVEIQLPSNPTTGFAWYFEGGTKESPNESMFTVENKYFPPDSKLLGAGGTEHFHVTVKAAGTHAVNLTYMRPWTGPSHDSERFTVYLKAN
Protein: ABC transporter ATP-binding protein/permease wht-1 (Q11180)
Organism: Caenorhabditis elegans
Function: Required for efficient RNA interference (RNAi). Plays a role in germline development.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- MARVEL domain-containing protein
- AT hook-containing protein attf-4
- MICOS complex subunit MIC60-2
- Nuclear pore complex protein 14
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
Sequence:
MHKAPISTLILDSLFSNMMLAEMMNDDQLELLKHQQTGIQPVVPEGCNLYWSSLNVTGPETKPTNFVDRFRNNMPKRRVKEILHNVSGMAESGKLLAILGSSGAGKTTLMNVLTSRNLTNLDVQGSILIDGRRANKWKIREMSAFVQQHDMFVGTMTAREHLQFMARLRMGDQYYSDHERQLRVEQVLTQMGLKKCADTVIGIPNQLKGLSCGEKKRLSFASEILTCPKILFCDEPTSGLDAFMAGHVVQALRSLADNGMTVIITIHQPSSHVYSLFNNVCLMACGRVIYLGPGDQAVPLFEKCGYPCPAYYNPADHLIRTLAVIDSDRATSMKTISKIRQGFLSTDLGQSVLAIGNANKLRAASFVTGSDTSEKTKTFFNQDYNASFWTQFLALFWRSWLTVIRDPNLLSVRLLQILITAFITGIVFFQTPVTPATIISINGIMFNHIRNMNFMLQFPNVPVITAELPIVLRENANGVYRTSAYFLAKNIAELPQYIILPILYNTIVYWMSGLYPNFWNYCFASLVTILITNVAISISYAVATIFANTDVAMTILPIFVVPIMAFGGFFITFDAIPSYFKWLSSLSYFKYGYEALAINEWDSIKVIPECFNSSMTAFALDSCPKNGHQVLESIDFSASHKIFDISILFGMFIGIRIIAYVALLIRSYNNT
Protein: DEAD-box ATP-dependent RNA helicase 51 (EC 3.6.4.13) (Q9LIH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- Pescadillo homolog
- Ribosome biogenesis protein WDR12 homolog
- Protein prenylyltransferase superfamily protein
- AT5g04600/T32M21_200
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Probable rRNA-processing protein EBP2 homolog
- Periodic tryptophan protein 2
- Ribosome assembly factor mrt4
- Transducin/WD40 repeat-like superfamily protein
Sequence:
MVESDKSSVEELKKRVRKRSRGKKNEQQKAEEKTHTVEENADETQKKSEKKVKKVRGKIEEEEEKVEAMEDGEDEKNIVIVGKGIMTNVTFDSLDLSEQTSIAIKEMGFQYMTQIQAGSIQPLLEGKDVLGAARTGSGKTLAFLIPAVELLFKERFSPRNGTGVIVICPTRELAIQTKNVAEELLKHHSQTVSMVIGGNNRRSEAQRIASGSNLVIATPGRLLDHLQNTKAFIYKHLKCLVIDEADRILEENFEEDMNKILKILPKTRQTALFSATQTSKVKDLARVSLTSPVHVDVDDGRRKVTNEGLEQGYCVVPSKQRLILLISFLKKNLNKKIMVFFSTCKSVQFHTEIMKISDVDVSDIHGGMDQNRRTKTFFDFMKAKKGILLCTDVAARGLDIPSVDWIIQYDPPDKPTEYIHRVGRTARGEGAKGKALLVLIPEELQFIRYLKAAKVPVKELEFNEKRLSNVQSALEKCVAKDYNLNKLAKDAYRAYLSAYNSHSLKDIFNVHRLDLLAVAESFCFSSPPKVNLNIESGAGKVRKARKQQGRNGFSPYSPYGKSTPTKEA
Protein: Non-canonical poly(A) RNA polymerase protein Trf4-1 (EC 2.7.7.19) (Topoisomerase 1-related protein 4-1) (Q7KVS9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Polyadenylates RNA processing and degradation intermediates of snRNAs and mRNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26786835}. Note=Enriched in 3 to 6 cytoplasmic foci. {ECO:0000269|PubMed:26786835}.
Interaction partners:
- Zinc finger CCHC domain-containing protein 7
- RNA helicase
- Inactive non-canonical poly
- Exosome complex component 10 homolog
- Uncharacterized protein, isoform B
- Terminal uridylyltransferase Tailor
Sequence:
MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATTINGSTSSSSSSSNSGNNNNNNNNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVLNFRADSLEILQQQQQQQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRDNNSPANSSSTNGPGAGTGTSTGAGGTGTNSPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAGGAHYYMNNHMEMIAKYKGEPWRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACTVRVLDKASVPIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQMHPRGIYHDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPRVNSILGRIIHITDDVIDYREWIRENFEHLVVVDRISPLPTAAPTAYATANGAPKYVIMPSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAGGVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEVVDIALSTPNGLANMSMPMPVHAVGMPASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQEMDPELEDQQQQQQHQETSGGNGFIRPGDVGTGSNRGGGDGSGGRNYNQRNNHNSSGYYHQQYYVPPPMQQQLSKSNSSSNYHQQHHHSHSHGNHSHRQQHHHQQQHHHQQRPQHLRVGGGNRYQKSLGGSPIISAGNASNSSSNCSNSSSSSGSNNSRLPPLRGTLVNSSSAISIISISSESSIASSSSSSSRSGQDQQRDER
Protein: Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) (Q8R001)
Organism: Mus musculus (Mouse)
Function: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:35398309}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23813963}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:35398309}. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules (PubMed:23813963). {ECO:0000269|PubMed:23813963, ECO:0000269|PubMed:35398309}.
Interaction partners:
- Cytoskeleton-associated protein 5
- CAP-Gly domain-containing linker protein 1
- Microtubule-associated protein RP/EB family member 1
Sequence:
MPGPTQTLSPNGENNNDIIQDNGTIIPFRKHTVRGERSYSWGMAVNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKLEHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKEYDPVEARQGQDAIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPASKPGSTPSRPSSAKRASSSGSASRSDKDLETQVIQLNEQVHSLKLALEGVEKERDFYFGKLREIELLCQEHGQENDDLVQRLMEVLYASDEQEGQTEEPEAEEQAHDQQPQQQEEY
Protein: Probable G-protein coupled receptor 141 (G-protein coupled receptor PGR13) (Q7Z602)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Rhodopsin
Sequence:
MPGHNTSRNSSCDPIVTPHLISLYFIVLIGGLVGVISILFLLVKMNTRSVTTMAVINLVVVHSVFLLTVPFRLTYLIKKTWMFGLPFCKFVSAMLHIHMYLTFLFYVVILVTRYLIFFKCKDKVEFYRKLHAVAASAGMWTLVIVIVVPLVVSRYGIHEEYNEEHCFKFHKELAYTYVKIINYMIVIFVIAVAVILLVFQVFIIMLMVQKLRHSLLSHQEFWAQLKNLFFIGVILVCFLPYQFFRIYYLNVVTHSNACNSKVAFYNEIFLSVTAISCYDLLLFVFGGSHWFKQKIIGLWNCVLCR
Protein: UPF3 domain-containing protein (Q9CUH6)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRSEEGAGGLGAALAARGPSWREKLSSSETHCRRESPRKESAAPPAPTLSESGAGKPREEKRTALSKVVLRRLPPGLTKEQLEEQLRPLPAHDYFEVVAADLSLYPHVYSRAYINFRNPDDILLFRDRFDGYIFIGNKGLEYPAVVEFAPFQKIAKKKLKKKDAKTGSIEDDPEYKQFLESYSLEEEKTSASPETLLGEIEAKTRELLARRTTPLLEYIKNRKLEKQRLREEKREERRRRELEKKRLR
Protein: Phenylacetate 2-hydroxylase (EC 1.14.14.54) (Q9Y7G5)
Organism: Emericella nidulans (Aspergillus nidulans)
Function: Catalyzes the hydroxylation of phenylacetate to 2-hydroxyphenylacetate in the homogentisate pathway. The homogentisate pathway is used to catabolize phenylacetate and use it as a carbon source. Can also catalyze the hydroxylation of 3-hydroxyphenylacetate to 2,5-dihydroxyphenylacetate (homogentisate) at low efficiency.
Interaction partners:
Sequence:
MSLQTIGIAAVAVVYFLIRYFNRTDIPKIKGLPEVPGVPIFGNLIQLGDQHATVAQKWAKKFGPVFQVRMGNKRVVFANTFDSVRQLWIKDQSALISRPTFHTFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPATQSYMPIIDLESMSSIRELLRDSANGTMDINPTAYFQRFALNTSLTLNYGIRIEGNVNDELLREIVDVERGVSNFRSTSNQWQDYIPLLRIFPKMNREAEEFRVRRDKYLTYLLDVLKDRIAKGTDKPCITGNILKDPEAKLNDAEIKSICLTMVSAGLDTVPGNLIMGIAYLASEDGQRIQKRAHDEIMKVYPDGDAWEKCLLEEKVPYVTALVKETLRFWTVIPICLPRENTKDIVWNGAVIPKGTTFFMNAYAADYDETHFTNPHAFEPERYLTASSDGSGTPHYGYGAGSRMCAGSHLANRELFTAYVRLITAFTMHPAKRAEDRPILDAIECNAIPTALTTEPKPFKVGFKPRDPVLVRKWIAESEERTKHLN
Protein: Alkaline/neutral invertase (EC 3.2.1.26) (F4HZY9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEGVGLRAVGSHCSLSEMDDLDLTRALDKPRLKIERKRSFDERSMSELSTGYSRHDGIHDSPRGRSVLDTPLSSARNSFEPHPMMAEAWEALRRSMVFFRGQPVGTLAAVDNTTDEVLNYDQVFVRDFVPSALAFLMNGEPDIVKHFLLKTLQLQGWEKRVDRFKLGEGVMPASFKVLHDPIRETDNIVADFGESAIGRVAPVDSGFWWIILLRAYTKSTGDLTLSETPECQKGMKLILSLCLAEGFDTFPTLLCADGCSMIDRRMGVYGYPIEIQALFFMALRSALSMLKPDGDGREVIERIVKRLHALSFHMRNYFWLDHQNLNDIYRFKTEEYSHTAVNKFNVMPDSIPEWVFDFMPLRGGYFVGNVGPAHMDFRWFALGNCVSILSSLATPDQSMAIMDLLEHRWAELVGEMPLKICYPCLEGHEWRIVTGCDPKNTRWSYHNGGSWPGLFSFPGD
Protein: Probable 2' cyclic ADP-D-ribose synthase TcpO (2'cADPR synthase TcpO) (EC 3.2.2.-) (NAD(+) hydrolase TcpO) (EC 3.2.2.6) (TIR domain-containing protein in M.olleyae) (tcpO) (A0A1I4KS07)
Organism: Methanobrevibacter olleyae
Function: NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide. In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed v-cADPR, for which the cyclizing bond is unknown.
Interaction partners:
Sequence:
MEDLEIFLKRFEDLLIDLATYNENESNDYIIYRKKLLSYDYLKDFIPDFIIKNRKPQFFRAYMQEIGGYKERRDLIYKGFERLYDYETIKNFDSDNSYNVNQIENFLERFEDLLIDLATENLKKDGFEEYSLFRKKFLTCNYFKDMPIFLKRNPKHFRYYMQSQGGYKERRKIISEEFNKLFSIIEGSNFNSDSNNKNKSINKKEYDIFVSHSSEDKEDFVKEFVNLLKQKGLSVWYDDDIVKIGHNLRKRISKGIKSSNYAVVIFSEDFFKSKWTNYEYDNIFLDFYDEEKVLPILHDLTIEDLEKFDGSIPLIRALSTKKFTVEEIIHEILERINEEKS
Protein: 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (Serotonin receptor 1A) (Q64264)
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8254366}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08908}. Cell projection, dendrite {ECO:0000250|UniProtKB:P19327}.
Interaction partners:
- Basigin
- Sodium-dependent serotonin transporter
- 5-hydroxytryptamine receptor 2A
- 5-hydroxytryptamine receptor 2C
- Fibroblast growth factor receptor 1
- Guanine nucleotide-binding protein G
- Oxytocin-neurophysin 1
- Somatostatin
- Guanine nucleotide-binding protein G
- Pro-neuropeptide Y
Sequence:
MDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR
Protein: D(2) dopamine receptor (Dopamine D2 receptor) (P61169)
Organism: Rattus norvegicus (Rat)
Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P14416}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P14416}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Beta-arrestin-2
- Sodium-dependent dopamine transporter
- Adenosine receptor A2a
- Guanine nucleotide-binding protein G
- Cannabinoid receptor 1
- Guanine nucleotide-binding protein G
- Beta-arrestin-1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Neuronal calcium sensor 1
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
Protein: DNA repair protein RAD51 homolog (G5EGG8)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364139}.
Interaction partners:
Sequence:
MSAQASRQKKSDQEQRAADQALLNAAIEDNAMEQDENFTVIDKLESSGISSGDISKLKEAGYYTYESLAFTTRRELRNVKGISDQKAEKIMKEAMKFVQMGFTTGAEVHVKRSQLVQIRTGSASLDRLLGGGIETGSITEVYGEYRTGKTQLCHSLAVLCQLPIDMGGGEGKCMYIDTNATFRPERIIAIAQRYNMDSAHVLENIAVARAYNSEHLMALIIRAGAMMSESRYAVVIVDCATAHFRNEYTGRGDLAERQMKLSAFLKCLAKLADEYGVAVIITNQVVAQVDGGASMFQADAKKPIGGHIIAHMSTTRLYLRKGKGENRVAKMVQSPNLPEAEATYSITNHGIEDARED
Protein: Securin (Cell untimely torn protein 2) (Protein Cut2) (P21135)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks separase/cut1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of cut1.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Separin
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit cut9
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 1
- Tethering factor for nuclear proteasome cut8
- WD repeat-containing protein slp1
- Mitotic spindle checkpoint component mad2
- G2/mitotic-specific cyclin cdc13
Sequence:
MLPRTMFSYGKENAFPVTPISNRNGTKGAGSKRAPLGSTKQSNAPSSVTVPRTVLGGKSTNISKFISAPSTKKMSPMDISMDSPTILEPNSQGISRSAVQERSKRLSASPRRSSLTDTPLPNELEEDIEYMPPPVHLDPIQSLGFDDVAIDCETLDPWPSMQNKATSVTIRNTPASDFHVYKEFSDDDPIQFPLLSVDGDSPLTEKDTNLTTPATLKASDQQRKVLEKPSVSKQSSSRTRLSTVYRTKLASGKSIPRPLSHKLTRPRVTASGNSRRRPLSRSIHSLSSSRIDFSSLDTGLL
Protein: Fatty acyl CoA synthetase 1 (EC 6.2.1.3) (Q9U404)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MGMYVTKLLSLWSHWFEVDDEVIIARQKFGPLAHICGPAEGENCSPVYRSIGVTDEEQARITREWYYGEHFLKQLEQTCTSRRDTLAVAYRTINKVEKEWREDHNGKRREWQVTHLNDPVYMTYGELWENSVAFGKGLREYGAKEGDRVAIYEDTRWEWLASAIGVWTQLMVTVTVYANLCREGLMHALKETECAAIICNGQNIKDLITLLKEVNLTNTTLVYLDSLPDGLNDEGMRLIPWKQVLETGMKSNLGYTIPGNCDTTALIMYTSGTVAAPKGVMHTFGSLTASKNGLADRFLECIGPKEEGETYVSYLPLAHILEFIADVVMLSRGTLVCFGSPRTLTDDTARPRGDLKEFKPVFIVGVPRIFETIRKVVESRLPPVGSFKRTLFDTAYADRLRALKEGKDTPFWNEKVFKVPRDMFGGRLRGVVCGGAPLADRTQEFMRVVFGLPLGQGYGLTETCCNGSIQRLGELYPSVGQLLKGVEGRLLDTDEYKHTDKPFPRGELCLRGSFMFKGYYKQEAMSKEVLIPGGWFRTGDVVEIGEDNALRVIGRVKALVKNLLGEYIQLEYLEVIYSQHPLSAPNGVCILVNQRRAYICALVITDEERAKKFAQENGIGGTWPEILKDPTFHQRAAKSLSNFGASIGRKPFELLRQVRVIADEWTAKNGMLTVSMKIRRNKVEERYGDVIEQLFKYE
Protein: C-14 sterol reductase, putative (Q381N2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Lanosterol 14-alpha-demethylase
- Importin beta-1 subunit, putative
- Squalene monooxygenase
- C-8 sterol isomerase, putative
- NAD
- C-5 sterol desaturase, putative
- Lathosterol oxidase, putative
- Methyltransferase
- Lanosterol synthase
Sequence:
MPPRSRKGTKSRSASPAPRTPGRTKKSPVTPRTKTPVTNKNRSYEWGGPLGALGMVVLLPLTVIGLNVLCSENSCSVHNVWDLPAMILLALDVGVPRLVLALGVELLWMAFHALLYITPVGKQVKGVKLSDGTCLTYNINALHVFTLVHAILGSMHYADVIRLAWLADMFMPLMVAAIIISVFMSIVLYVASFRSSQVSFSPGGNTGNYLYDFWVGRELNPRTGSLDWKFMCELRPGLIGWSVLNWAFVAKAMEVGTCSPSIIVVALLESFYVLDGLLYEEGNLTMMDIVHDGFGFMLCFGDLAWVPFTYTLKAKFLAYHASQLSYMHVGICAAVALVGYAVFRGSNNQKSRFRQNPKDPANAALKVMHTSSGKSLIVSGYWGVCRHPNYVGDWLMTLSWSALTGFTEPLPYFQPVYFALLLIHRQLRDEEQMREKYGAEDMHKFHRIVRYRLIPYVY
Protein: ETS variant transcription factor 2 (ETS1-related protein isoform X1) (A0A2R8Q5A3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004019}.
Interaction partners:
Sequence:
MEMYQSGFYTEDFRTQEVPAGFDFSSYDSKGPVQQQYAENYSEPQKELLHKGHVLTVDSGLFNLDSFPEFSNWAAYTNIPEGMVADRQQVGFQESTQTYQNLVPLCTPAQSSTFSPTMDTSSHYQPGKGPSHRGASGTASLDHLGESDRTYGLYEAEQQSRSSYWSDYPSPGYCSSMPLSQPASSSSPPVSQSAEHFCPRVVKRRSAPPQRSDREGEITPMSAYPGSGPIQLWQFLLELLLDSACHTFISWTGDGWEFKMSDPAEVAKRWGQCKNKPKMNYEKLSRGLRYYYHKNIIHKTAGKRYVYRFVCDVQGMLGKTAHEVLASLNISPNAASPQSVANTSRSEETTESWTH
Protein: Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD antigen CD118) (P42703)
Organism: Mus musculus (Mouse)
Function: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Interaction partners:
- Leukemia inhibitory factor
- Oncostatin-M
- Ciliary neurotrophic factor
- Ciliary neurotrophic factor receptor subunit alpha
- Interleukin-6 receptor subunit beta
- Cardiotrophin-1
- Tyrosine-protein kinase JAK2
- Cardiotrophin-like cytokine factor 1
- Cardiotrophin-2
- Signal transducer and activator of transcription 3
Sequence:
MAAYSWWRQPSWMVDNKRSRMTPNLPWLLSALTLLHLTMHANGLKRGVQDLKCTTNNMRVWDCTWPAPLGVSPGTVKDICIKDRFHSCHPLETTNVKIPALSPGDHEVTINYLNGFQSKFTLNEKDVSLIPETPEILDLSADFFTSSLLLKWNDRGSALPHPSNATWEIKVLQNPRTEPVALVLLNTMLSGKDTVQHWNWTSDLPLQCATHSVSIRWHIDSPHFSGYKEWSDWSPLKNISWIRNTETNVFPQDKVVLAGSNMTICCMSPTKVLSGQIGNTLRPLIHLYGQTVAIHILNIPVSENSGTNIIFITDDDVYGTVVFAGYPPDVPQKLSCETHDLKEIICSWNPGRITGLVGPRNTEYTLFESISGKSAVFHRIEGLTNETYRLGVQMHPGQEIHNFTLTGRNPLGQAQSAVVINVTERVAPHDPTSLKVKDINSTVVTFSWYLPGNFTKINLLCQIEICKANSKKEVRNATIRGAEDSTYHVAVDKLNPYTAYTFRVRCSSKTFWKWSRWSDEKRHLTTEATPSKGPDTWREWSSDGKNLIVYWKPLPINEANGKILSYNVSCSLNEETQSVLEIFDPQHRAEIQLSKNDYIISVVARNSAGSSPPSKIASMEIPNDDITVEQAVGLGNRIFLTWRHDPNMTCDYVIKWCNSSRSEPCLLDWRKVPSNSTETVIESDQFQPGVRYNFYLYGCTNQGYQLLRSIIGYVEELAPIVAPNFTVEDTSADSILVKWDDIPVEELRGFLRGYLFYFQKGERDTPKTRSLEPHHSDIKLKNITDISQKTLRIADLQGKTSYHLVLRAYTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSNALKTLEMNPCTPNNVEVLESRSIVPKIEDTEIISPVAERPGERSEVDPENHVVVSYCPPIIEEEITNPAADEVGGASQVVYIDVQSMYQPQAKAEEEQDVDPVVVAGYKPQMRLPISPAVEDTAAEDEEGKTAGYRPQANVNTWNLVSPDSPRSTDSNNEVVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND
Protein: Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (P79255)
Organism: Bos taurus (Bovine)
Function: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
Subcellular location: Secreted.
Interaction partners:
- C-X-C chemokine receptor type 2
- C-X-C chemokine receptor type 2
- C-C motif chemokine 2
- NF-kappaB transcription factor p65 subunit)
- Growth-regulated protein homolog gamma
- Atypical chemokine receptor 1
- Interleukin-1 beta
- C-X-C motif chemokine 6
- Transcription factor Jun
- C-C motif chemokine 20
Sequence:
MTSKLAVALLAAFLLSAALCEAAVLSRMSTELRCQCIKTHSTPFHPKFIKELRVIESGPHCENSEIIVKLTNGNEVCLNPKEKWVQKVVQVFVKRAEKQDP
Protein: mRNA-binding protein PUF2 (Q8I1R7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Mitochondrial ribosomal protein S22, putative
- CCR4-associated factor 1
- Cytochrome c oxidase copper chaperone, putative
Sequence:
MDSIFLEDDAIGHVNNIDHINDINNIGVINNTNNINNVNDVVDEFNFKDQLKHLKNMKTCSTSYNSMPSSNIEMLFDQELMGNQNILFLNDPENDIFNFSRGIIKDEYYKNYYIHKENQEKIDYNQIYHNFENNHNFEYFKNSEHYEKSPEQVIDNKRYYENLPEQVIINKKDMFKNDEEKHNEEGQVHIDMSKVMYDIYFLCFHKNGCEYIIKKLKEDNKEEKEIILNSLLIDTMSLCPDIYGSYVAQSIFDLKDEKYKERFTDEFLKHTSFLTLHTYGCRLIQKSLESLSDEYKCKIFKELQEDLIKYICHQNGNHVIQKCVEVLPCSYIDIIINIIEEYLPFLSSHAYGCRIVQRIYEIGNEQQINRLNEQIIKKIHLIKNRYGNYVIQKCFEHSDDNIRFIITDEIVNDIYKLSSHKYACNIIEKILLKKEYKYKKKIIKKIVNDISDGKDNIINICKDCYGNFMMQKLLTTCRKKERNFIIKTIIENLDKLKDETYGKYILRAINNLEK
Protein: Conserved hypothetical membrane protein (O06625)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Glycogen operon protein GlgX homolog
- Putative maltooligosyl trehalose synthase
- Malto-oligosyltrehalose trehalohydrolase
- Uncharacterized protein Rv0007
- Possible Inv protein
Sequence:
MLTLSPPRPPALTPEPALPPVTMGTRTTGFYRHDLDGLRGVAIALVAVFHVWFGRVSGGVDVFLALSGFFFGGKILRAALNPDLSLSPIAEVIRLIRRLLPALVVVLAGCALLTIAIQPQTRWEAFANQSLASLGYYQNWELASTVSNYLRAGEAVSPLQHIWSMSVQGQFYLAFLLLVAGCAYLLRRLFRGPRAPYLRTMFVVLLSTLTLASFIYAIVAHHAYQATAYYNTFARAWELLAGALVGAVVPHVRWPMWLRTAVATAALAAILSCGALIDGVKEFPGPWALVPVGATMLMILAGANRQGHPGTRDRLPLPNRLLATAPLVALGAMAYSWYLWHWPLLIFWLSYTGHRHANFVEGAAVLLVSGLLAYLTTRLVEDPLRYRAPAGVRSPAAVPPIPWRLRLRRPTIVLGSVVALLGVALTATSFTWREHVIVQRAAGKELSGLSSRDYPGARALIDHVRVPKLRMRPTVLEVRHDLPTSTKDGCISDFVNPAIINCTYGDVDAPRTIALAGGSHAEHWLTALDLLGRMHHFKVVTYLKMGCPLSTEEVPLIMGNNAPYPQCHQWVQAAMAKLVADHPDYVFTTSTRPWNIKPGDVMPATYVGIWQTFADNNIPVLAMRDTPWLVKDGQPFIPADCLAKGGNPQSCGIARSKVLVDRNPTLDFVARFPLLKPLDMSDAICRTDTCRAVEGNVLVYRDSHHLTPTYMRTMTSELGRQIAANTDWW
Protein: Complement C1q tumor necrosis factor-related protein 8 (C1q/TNF-related protein 8) (CTRP8) (P60827)
Organism: Homo sapiens (Human)
Function: May play a role as ligand of RXFP1.
Subcellular location: Secreted {ECO:0000269|PubMed:19666007, ECO:0000269|PubMed:24014093}.
Interaction partners:
- Relaxin receptor 1
Sequence:
MAAPALLLLALLLPVGAWPGLPRRPCVHCCRPAWPPGPYARVSDRDLWRGDLWRGLPRVRPTIDIEILKGEKGEAGVRGRAGRSGKEGPPGARGLQGRRGQKGQVGPPGAACRRAYAAFSVGRREGLHSSDHFQAVPFDTELVNLDGAFDLAAGRFLCTVPGVYFLSLNVHTWNYKETYLHIMLNRRPAAVLYAQPSERSVMQAQSLMLLLAAGDAVWVRMFQRDRDNAIYGEHGDLYITFSGHLVKPAAEL