wanglab/gogpt-training-data huggingface dataset:
Protein: Epidermal growth factor-like protein (LPS recognition protein) (LPR) (Q1HAY7)
Organism: Holotrichia diomphalia (Korean black chafer)
Function: Binds to lipopolysaccharides (LPS) present on the cell walls of Gram-negative bacteria, behaving as a pattern recognition receptor (PRR). Induces bacterial aggregation and enhances their subsequent clearance by the innate immune response. Binds to the inner core oligosaccharides region of rough-type bacterial LPS. Displays activity against the Gram-negative bacterium E.coli. Does not display any activity against the Gram-positive bacterium S.aureus or the fungi C.albicans.
Subcellular location: Secreted {ECO:0000269|PubMed:16849495}. Note=Detected in larval plasma. {ECO:0000269|PubMed:16849495}.
Interaction partners:
Sequence:
MDFKIFLFLTAIFMIVGVTVSTATTNPTAPRAYRPRINTTAGVCELEVPIVNILPPELKHTAHTIRGNGSAPGFSKIKICCSGYKIVAHTPFHCTPDCPSGCGLGNCTAPNVCTCNKGAGFGPDGKCISVCPGRCLNGQCYGNFCNCNSGFVLEPNGRYCTGGCTRNCGPGGQCVGNNQCSCLSGFALNSQGTCQMICAPGFQQMGSACEPLCPKGCVNGECVAPGQCRCKSGYALNSSKVCAPKCSQPCYNGFCSAPNVCTCKEGYIKDATSRNGNRCIAYCAAGCPNGTCSAPNFCICKQGYIKQSKGSNVCVKQ
Protein: Calcium-binding and coiled-coil domain-containing protein 1 (Coiled-coil coactivator protein) (Q8CGU1)
Organism: Mus musculus (Mouse)
Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16931570}. Nucleus {ECO:0000269|PubMed:16931570}. Note=Shuttles between nucleus and cytoplasm.
Interaction partners:
Sequence:
MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTTDGSPTHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEDQVTELRSRVQELEAALATARQEHSELTEQYKGLSRSHGELSEERDILSQQQGDHVARILELEDDIQTMSDKVLMKEVELDRVRDTVKALTREQEKLLRQLKEFQADKEQSEAELQTVREENCCLNTELEEAKSRQEEQGAQVQRLKDKLAHMKDTLGQAQQKVAELEPLKEQLRGVQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAEVNGRLAELSLHMKEEKCQWSKERTGLLQSMEAEKDKILKLSAEILRLEKTVQEERTQSHVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQTEKQELLEYMRKLEARLEKVADEKWTEDAATEDEEATAGLSCPASLTDSEDESPEDMRLPSYGLCESGNTSSSPPGPREPSSLVVINQPAPIAPQFSGPGEASSSDSEAEDEKSVLMAAVQSGGEEASLLLPELGSAFYDVASAFTVSSLSEASPGVPANPPWKECPICKERFPAESDKDALEGHMDGHFFFSTQDPFTFE
Protein: Phosphoribosyltransferase domain-containing protein (O83089)
Organism: Treponema pallidum (strain Nichols)
Interaction partners:
- Uncharacterized protein TP_1029
- Putative adenosine/adenine deaminase
- Mannosylglycerate hydrolase MGH1-like glycoside hydrolase domain-containing protein
- Basal-body rod modification protein FlgD
- Flagellin FlaB3
- Flagellar basal-body rod protein
- Flagellin FlaB1
- Flagellar hook-basal body complex protein FliE
- Putative uracil phosphoribosyltransferase
- Uncharacterized protein
Sequence:
MKKRFIPYNVIRDEGFGMARRIVADRFVPTVMYVPIRGGVYLGNVLNEYLTIAYKAEPPILYAAVVAHSHCDLRKRRVISVDGWTYPPEYLRVGDKVLIVDDIFDSGATINYIASLLMQKGLARGDIRVAVFNYKVFVGEKQPPVLPDYWCIKHEVRSEADNEWFHYMSHELSGLTAAELEQYYYAQNPALRKTLADINNQL
Protein: Histone H2A.1 (Q6FWM7)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H4
- Histone H3
- Histone H2A.2
- Histone H2B.1
- Histone H2B.2
- Histone H2A
- FACT complex subunit SPT16
- FACT complex subunit POB3
- Histone H3-like centromeric protein CSE4
- Candida glabrata strain CBS138 chromosome G complete sequence
Sequence:
MSGGKGGKAGSAAKASQTRSAKAGLTFPVGRVHRLLRRGNYAQRIGSGAPVYLTAVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDDELNKLLGNVTIAQGGVLPNIHQNLLPKKSAKPSASQEL
Protein: Platelet-derived growth factor receptor-like protein (D6RDX0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTD
Protein: Mitochondrial inner membrane protein SHH3 (SDH3 homolog) (Q04487)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Homolog of SDH3, but seems not to be a stoichiometric subunit of either the succinate dehydrogenase (SDH) complex or the mitochondrial inner membrane translocase TIM22 complex.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P33421}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial inner membrane protein SHH4
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit 2, mitochondrial
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM18
- Fumarate hydratase, mitochondrial
- Succinate dehydrogenase cytochrome b subunit
Sequence:
MKATIQRVTSVFGVPRASVFVPRISTPFILHNYISNGRMDLFSKEFHNGRVSKSDLWSSNKEEELLVSQRKKRPISPHLTVYEPEMSWYLSSLHRISGVLLALGFYAFTITLGVTTIMGMDTTFQDLNKWYHEKMPKWSQWVAKGSAAYLFAFHFGNGIRHLIWDMGYELTNRGVIKTGSIVLAGTLVLGTYLLAQ
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (Q56I98)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
Sequence:
MHSSTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMEELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEFNPHLSLLAKFRNTSLHSEPLMPHNATYPDSFQHPPCTPFPPSPSHMFSQSPNSISYPNSPGSSSGPGSPYQLTVETPPPPYHARETPGSHNGRSMDAIAESQLVLSLPNGGKSADGETENFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSILIDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKIFNNQLFAQPLAQSVNHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Protein: SsDNA endodeoxyribonuclease (A0A1D8PLU8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Rad10p
- TFIIH/NER complex subunit
- DNA-dependent ATPase
- SsDNA endodeoxyribonuclease
- DNA 3'-5' helicase
- DNA 5'-3' helicase
- DNA repair protein RAD14
- UV excision repair protein RAD23
- General transcription and DNA repair factor IIH
- DNA repair protein RAD4
Sequence:
MGVHSLWKIVGPTARPVRLEALSKKKLAIDASIWIYQFLKAMRDKDGNSLPSSHIIGFFRRICKLLYFGILPIFVFDGGVPALKKQTINNRKQRREKNSESRQETAQKLLAIQLQREAENALNRSKKPSNNTTNGDDDDVIYFEDLPINKPERESSTPSSIVYRKNDEYHLPDLKEFKVSKFDERIMPEEDLTEFYEDFDHVDGININEIDPKSKEFEALPIATQYMILSHLRLKSRLRMGYRKEQLEELFPNSMDFSKFQIQQVQRRNFYTQKLMDVTGMGADATISKRLAGDKDRKYALVKNEDGWTLALEGNSEDNPIQVDSDEAEDITREVNSYKEDLRQDKKDEESDSDFEDVPLEEIPETEEDKDYQRALIKSIYEQYNTQENMQAPTSTINGVDDDELRKAVEKSKIDYFELQAKETQQLEEEKFDFGSSMLFSTNAVKEEALQNSEEISNLTEHAHTQVNTVHPSEQDKIINSDTKKELPNSIGQSFLFNADPHRTGKIELRTKEETIFEPEESDFEEAKTNNDQSISHIEKAKKQEPTKDQQKLPDWFQSEVNKTLNPHNVKFVNYNDYQIRNQKNQEEKDAGLVPWYEAKEILEQEQSDEEEQEQEQEKPDNDSDEIEEISKEQVNISISEEKESVPPSSVEDIRKPAVMDYQFEEEDEEELVQQLQKEELDHESLKHQIKASHAIPLTSLETRITDEQLLQEKFQKAKRDSDEVTETMINDVQELLKRFGIPYITAPMEAEAQCAELYKIGLVDGIVTDDSDCFLFGGDKIYKNMFDQKQYVEFYLQDDLFNKMALTQHKLIELALLLGSDYTEGIKGIGPVQAMEILAEFGNLEKFKEWFDKHTKSVADKTELTKLQKSLLDRIKKGKLYLPDSFPDKVVEQAYMSPEVDSDKTEFQWGVPDLDQIRSFLMYNLLWTQTEVDEVMVPLVQDMNKKKLEGRQSTISEFFPQEYIQSRKELNLGKRLKTAANKLKKQKHL
Protein: Mitochondrial import inner membrane translocase subunit tim8 (Q09783)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit tim13
- Mitochondrial import inner membrane translocase subunit tim10
- Mitochondrial import inner membrane translocase subunit tim9
- Mitochondrial import inner membrane translocase subunit tim54
- Mitochondrial import inner membrane translocase subunit tim22
- Probable mitochondrial import receptor subunit tom40
- Mitochondrial import inner membrane translocase subunit tim23
- Mitochondrial import receptor subunit tom7
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Mitochondrial import inner membrane translocase subunit tim17
Sequence:
MADATKNPIADLSESEQLELSKFIESEQQKVKLQQAIHQFTSTCWPKCIGNIGNKLDKSEEQCLQNCVERFLDCNFHIIKRYALEKFGFLFCWLGFSC
Protein: Histone deacetylase, putative (Q586J9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Histone deacetylase 2
- Trans sialidase, putative
- Histone deacetylase
Sequence:
MGKETREAESVENDDKRVNKKVKKETSSSSVATRKEGGEPHHDEEMSHPNFRRCTDRLETYIHNWMGQAHGVPSVLPTALPPIDPLPTILDMMIPEVNETSITLTTMTPTLDITAIEAEGTGVAYDEVTLLHASTDPGDYERPGRLQRTLDHLEVIGLLECCRRLHHRSARTRELRLVHSTEHIDSVDQLEVATLLRKPGESCNVGEDLYANENTSRAARAAAGCAIAAALSVVRGEVRNSFALIRPPGHHAGRDRASGFCFFNNVAVAVRAAQRELKKLQEGGNAAPSPRSSGGPCEPASTAAEPRVLVIDWDVHHCDGTENIFYEDPSVVVVSIHQHGSKRGHILRKNPTVVDNIVELDDLAALMDPIEDVKPELCGGDDSVRNKETDQEVAEGLACGTVPNERSPVKEEESTGGECKHESPQDDEEKKESSCRRQRKPVDYNKLAEEMANQDDELARIFGVNAEELARFPESGSSGSESDSSTSSESQERAGKLSGDSEGYSYSDEDSSNEPRPFYPSTGHMDRVGGDANPEAKGKNINIPWPTHNMGDLEYLQVVLDVVLPVMREFEPEVVFVSCGFDSAARDLLGSMQVTPSGYYLLVKALAAVCPKLVVVLEGGYNLSNVARCSEAVMRALLESNGSRSKLPRSRMLWCQAEELVQQVRETHGGYWQCLNPNSFDHMCK
Protein: Triacylglycerol hydrolase DDHD2 (TAG hydrolase) (EC 3.1.1.3) (DDHD domain-containing protein 2) (KIAA0725p) (Phospholipase DDHD2) (EC 3.1.1.-) (SAM, WWE and DDHD domain-containing protein 1) (Triglyceride hydrolase DDHD2) (Triglyceride lipase) (O94830)
Organism: Homo sapiens (Human)
Function: Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane.
Subcellular location: Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P.
Interaction partners:
- Phospholipase DDHD1
Sequence:
MSSVQSQQEQLSQSDPSPSPNSCSSFELIDMDAGSLYEPVSPHWFYCKIIDSKETWIPFNSEDSQQLEEAYSSGKGCNGRVVPTDGGRYDVHLGERMRYAVYWDELASEVRRCTWFYKGDKDNKYVPYSESFSQVLEETYMLAVTLDEWKKKLESPNREIIILHNPKLMVHYQPVAGSDDWGSTPTEQGRPRTVKRGVENISVDIHCGEPLQIDHLVFVVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPLHSTGVDVDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLFLQRNPDFKGGVSIAGHSLGSLILFDILTNQKDSLGDIDSEKDSLNIVMDQGDTPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTRNGDYLDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGIFLDQPLQ
Protein: Pentatricopeptide repeat-containing protein At3g48250, chloroplastic (Q9STK5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- RCC1 domain-containing protein RUG3, mitochondrial
- Nuclear intron maturase 1, mitochondrial
- Protein WHAT'S THIS FACTOR 9
- Nuclear intron maturase 4, mitochondrial
- Transcription termination factor MTERF15, mitochondrial
- Nuclear intron maturase 2, mitochondrial
- DEAD-box ATP-dependent RNA helicase 53, mitochondrial
- NADH dehydrogenase subunit 7
- Pentatricopeptide repeat-containing protein At2g15820, chloroplastic
- NADH dehydrogenase iron-sulfur protein 2
Sequence:
MYRSMAILSSLRHAYSQISTRSYLSRSKVGFSSNLSSPLDSFAIVPSRFLWKFRTFSSKPDSMLQLVLENDWSKEVEEGLRKPDMSLTHETAIYVLRKLEKYPEKAYYFLDWVLRDSGLSPSTPLYSIMLRILVQQRSMKRFWMTLREMKQGGFYLDEDTYKTIYGELSKEKSKADAVAVAHFYERMLKENAMSVVAGEVSAVVTKGDWSCEVERELQEMKLVLSDNFVIRVLKELREHPLKALAFFHWVGGGGSSSGYQHSTVTYNAALRVLARPNSVAEFWSVVDEMKTAGYDMDLDTYIKVSRQFQKSRMMAETVKLYEYMMDGPFKPSIQDCSLLLRYLSGSPNPDLDLVFRVSRKYESTGKSLSKAVYDGIHRSLTSVGRFDEAEEITKAMRNAGYEPDNITYSQLVFGLCKAKRLEEARGVLDQMEAQGCFPDIKTWTILIQGHCKNNELDKALACFANMLEKGFDIDSNLLDVLIDGFVIHNKFEGASIFLMEMVKNANVKPWQSTYKLLIDKLLKIKKSEEALDLLQMMKKQNYPAYAEAFDGYLAKFGTLEDAKKFLDVLSSKDSPSFAAYFHVIEAFYREGRLTDAKNLLFICPHHFKTHPKISELFGAAA
Protein: Small ribosomal subunit protein eS10 (40S ribosomal protein S10) (S4R435)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
XDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYF
Protein: Putative serine protease HhoA (P72780)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: A putative protease, its function overlaps that of the related putative proteases HhoB and HtrA.
Subcellular location: Periplasm {ECO:0000305}.
Interaction partners:
- Sll1681 protein
- peptide-methionine
- Ssr3341 protein
Sequence:
MKYPTWLRRIGGYLLAFAVGTAFGIANLPHAVAAADDLPPAPVITAQASVPLTSESFVAAAVSRSGPAVVRIDTETVVTRRTDPILDDPFFQEFFGRSFPVPPRERRIAGQGSGFIIDNSGIILTNAHVVDGASKVVVTLRDGRTFDGQVRGTDEVTDLAVVKIEPQGSALPVAPLGTSSNLQVGDWAIAVGNPVGLDNTVTLGIISTLGRSAAQAGIPDKRVEFIQTDAAINPGNSGGPLLNARGEVIGINTAIRADATGIGFAIPIDQAKAIQNTLAAGGTVPHPYIGVQMMNITVDQAQQNNRNPNSPFIIPEVDGILVMRVLPGTPAERAGIRRGDVIVAVDGTPISDGARLQRIVEQAGLNKALKLDLLRGDRRLSLTVQTAQLRNPTS
Protein: Serine/threonine-protein kinase srk1 (EC 2.7.11.1) (Sty1-regulated kinase 1) (O94547)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Delays the mitotic G2/M transition by promoting nuclear exclusion of cdc25. During osmotic stress, inhibits the G2/M transition in a sty1 stress-activated MAPK pathway-dependent manner.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12080074, ECO:0000269|PubMed:12589433}. Nucleus, nucleolus {ECO:0000269|PubMed:12080074, ECO:0000269|PubMed:15629716}. Spore core {ECO:0000269|PubMed:12589433}. Note=Translocates from the cytoplasm to the nucleus during environmental stress in a sty1-dependent manner. {ECO:0000269|PubMed:12080074}.
Interaction partners:
- Mitogen-activated protein kinase sty1
- Checkpoint signal transducer rad24
- M-phase inducer phosphatase
- Serine/threonine-protein kinase haspin homolog hrk1
- Mitochondrial transcription factor 1
- Vacuolar protein sorting-associated protein 41
- Calmodulin
Sequence:
MRFKSIQQNIEDEGKVNVREVNPDSYAERDHGYTAGIFSDAEENFGITQQVADSTQNPTSKPKSRHAHFHETVHENPSEYSRSKCKQPTNEKEYDKAIEALVAKAIVEEHSGQQFPVYKGLEQYTLLQKMGDGAFSNVYKAIHNRTGEKVAIKVVQRAQPNTDPRDPRKRQGVESHNILKEVQIMRRVKHPNIIQLLEFIQTPEYYYLVLELADGGELFHQIVRLTYFSEDLSRHVITQVAHAIRYLHEDCGVVHRDIKPENLLFDSIDFVPSRVRKYRAGDDPDKVDEGEFIPGVGAGTIGRIRLADFGLSKVVWDSHTQTPCGTMGYTAPEIVRDERYSKGVDMWALGCVLYTILCGFPPFYDESISLLTKKVSRGEYSFLSPWWDDISKSAKDLISHLLTVDPESRYDIHQFLAHPWISGSREPTFPATDAPNTAQRENPFTYDFLEPEDVAAAGSAARTPGVNSLREVFNISYAAHRMEQEKIRKRGQRGNQGIMNFMGDMDDLMEENDDYDDGTKSVEHSMKRVNLSGENDPSLASRQPAQSQQQSSQRSRNKFKGFQLNLSKATLYNRRHRQKV
Protein: Cyclin-dependent kinases regulatory subunit 1 (CKS-1) (Sid 1334) (P61025)
Organism: Mus musculus (Mouse)
Function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Interaction partners:
- S-phase kinase-associated protein 2
- S-phase kinase-associated protein 1
- Cyclin-dependent kinases regulatory subunit 2
- Cullin-1
- Cyclin-A2
- Cyclin-dependent kinase 2
- E3 ubiquitin-protein ligase RBX1
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinases regulatory subunit
Sequence:
MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRPLPKKPKK
Protein: T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g) (P11942)
Organism: Mus musculus (Mouse)
Function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- T-cell surface glycoprotein CD3 delta chain
- T-cell surface glycoprotein CD3 zeta chain
- T-cell surface glycoprotein CD3 epsilon chain
- Tyrosine-protein kinase ZAP-70
- T-cell surface glycoprotein CD8 beta chain
- Src kinase-associated phosphoprotein 1
- T-cell differentiation antigen CD6
- Tyrosine-protein phosphatase non-receptor type 6
- T-cell receptor-associated transmembrane adapter 1
- Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Sequence:
MEQRKGLAGLFLVISLLQGTVAQTNKAKNLVQVDGSRGDGSVLLTCGLTDKTIKWLKDGSIISPLNATKNTWNLGNNAKDPRGTYQCQGAKETSNPLQVYYRMCENCIELNIGTISGFIFAEVISIFFLALGVYLIAGQDGVRQSRASDKQTLLQNEQLYQPLKDREYDQYSHLQGNQLRKK
Protein: Uncharacterized WD repeat-containing protein slr1410 (P73595)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Slr0439 protein
- WD repeat-containing protein slr1409
Sequence:
MKHKFLVSFLLGLTISFAGAQVIAKTPSVNNAPVARSVNQSPIQLEVIKSYQGHTLKGEAIIQIHYSQDGNYLLSTATDGLAKLWTADGELVREFAGKPVAMIFNGAFSRDGKAIITAGYNGVARIWDVQGNVLGEILGHTSAVTDVVFLSDDMGVVTSSDDGTIEGWSNIKEPLFTVTRPGVSRNMDFNAQTNLIAVTQDIGEITLLNPAGKVVRIIETDQGRLNDVDFSQDGKLLVTAGFDGTARVFNLDGQEILKIDVLDDGWVTGVAINQDNLIATVSDDGILRVWNLQGQLLGQYNPNLERLGSVSFHPNGKNLAIAAYHGTIILLELQ
Protein: RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) (Focal adhesion-associated protein) (FAAP) (Q99LF4)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity). Essential during post-implantation development of embryos.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000269|PubMed:18508721}. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. {ECO:0000250}.
Interaction partners:
- ATP-dependent RNA helicase DDX1
- Protein FAM98B
- Protein archease
- RNA transcription, translation and transport factor protein
- RNA 3'-terminal phosphate cyclase
- Ashwin
- Protein FAM98A
- Eukaryotic translation initiation factor 3 subunit L
- tRNA 2'-phosphotransferase 1
- X-box-binding protein 1
Sequence:
MSRNYNDELQFLDKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSPRAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG
Protein: Cytosolic Fe-S cluster assembly factor NUBP2 (Nucleotide-binding protein 2) (NBP 2) (Q9R061)
Organism: Mus musculus (Mouse)
Function: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03039, ECO:0000269|PubMed:16638812}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03039, ECO:0000269|PubMed:16638812}. Cytoplasm {ECO:0000269|PubMed:23807208}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23807208}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23807208}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:23807208}. Note=Enriched at the centrosomes during mitosis (By similarity). Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis (PubMed:23807208). Localized at centrioles and in the nucleus at interphase (PubMed:23807208). Colocalizes with nubp-1 at prometaphase (PubMed:23807208). {ECO:0000255|HAMAP-Rule:MF_03039, ECO:0000269|PubMed:23807208}.
Interaction partners:
- NSFL1 cofactor p47
Sequence:
MEAAAGERAEPGNLAGVRHIILVLSGKGGVGKSTISTELALALRHQGKKVGILDVDLCGPSIPHMLRAQGKAVHQCDNGWVPVFVDQEQSISLMSVGFLLENPDEAVVWRGPKKHALIKQFVSDVAWGQLDYLVVDTPPGTSDEHMATMEALRPYRPLGALVVTTPQAVSIGDVRRELTFCKKTGLQVIGVIENMSGFTCPHCAECTNVFSSGSGEELARLAGVPFLGSVPLDSQLTRSLEEGRDFIQEFPKSTAYSALTSIAQRVVHRMSALCS
Protein: AA1-like domain-containing protein (G5EB52)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MKTTIATLLALAGAAFAAPATESASSPSPFPFSIDDVKLYHLKESNTWDLTIKVTSRDPYGAALGSTTCHSAWIDGATYVAPEVCEDTNYSFWLPNGAPDPQHWTVVVDGPAGQGEGSIEFGPKYRCEPYEGEIGNIDVECSTRNGGWFFLREREA