wanglab/gogpt-training-data huggingface dataset:
Protein: Parathyroid hormone 2 receptor (PTH2 receptor) (P49190)
Organism: Homo sapiens (Human)
Function: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Tuberoinfundibular peptide of 39 residues
- Parathyroid hormone
- Parathyroid hormone-related protein
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Parathyroid hormone/parathyroid hormone-related peptide receptor
- Guanine nucleotide-binding protein G
- Probable non-functional immunoglobulin heavy variable 3-16
- Frizzled-5
Sequence:
MAGLGASLHVWGWLMLGSCLLARAQLDSDGTITIEEQIVLVLKAKVQCELNITAQLQEGEGNCFPEWDGLICWPRGTVGKISAVPCPPYIYDFNHKGVAFRHCNPNGTWDFMHSLNKTWANYSDCLRFLQPDISIGKQEFFERLYVMYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHMHLFVSFMLRATSIFVKDRVVHAHIGVKELESLIMQDDPQNSIEATSVDKSQYIGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVAFFSDTKYLWGFILIGWGFPAAFVAAWAVARATLADARCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFTGLGWEIRMHCELFFNSFQGFFVSIIYCYCNGEVQAEVKKMWSRWNLSVDWKRTPPCGSRRCGSVLTTVTHSTSSQSQVAASTRMVLISGKAAKIASRQPDSHITLPGYVWSNSEQDCLPHSFHEETKEDSGRQGDDILMEKPSRPMESNPDTEGCQGETEDVL
Protein: Krueppel-like factor 8 (Kruppel-like factor 8) (Si:ch211-208m1.2) (A0S0R1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- C-terminal-binding protein 1
- C-terminal-binding protein 1
Sequence:
MHTETRNKKCQTSPKKSAAATSEPVEEMPSIQIKPEPEEVECMVKQEPLDDCLEPTDLKIKSSPPPLCIISTQHSDADQTEPVDLSLNKPRPSLPIATATSTPANLPPQNITASATIPAVLSQGSILASTQGVGGQQILHVIHTIPSVNMPSKLGQLQTIPVVVQSLPVVYTTVPTDGMATAAITVPLIGSDGRSEGSVRIKPGSTSPVEYQSESDAESGTESGSASFSTQGMEPSINTDVDIPADPDSPDMKRRRVHMCDYDGCNKVYTKSSHLKAHRRIHTGEKPYQCTWEGCTWRFARSDELTRHFRKHTGIKPFRCTDCDRSFSRSDHLALHRRRHVMM
Protein: Cytochrome c oxidase subunit 7B, mitochondrial (Cytochrome c oxidase polypeptide VIIb) (P24311)
Organism: Homo sapiens (Human)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). Plays a role in proper central nervous system (CNS) development in vertebrates.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
Interaction partners:
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 6C
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome c oxidase subunit 8A, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit NDUFA4
- Cytochrome c oxidase subunit 6B1
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 6A1, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
Sequence:
MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCIVTWTYVATQVGIEWNLSPVGRVTPKEWRNQ
Protein: RNA-binding protein VTS1 (J9VVN9)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Function: RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q08831}. Cytoplasm, P-body {ECO:0000269|PubMed:27611567}. Note=Localizes to P-bodies at high temperature. {ECO:0000269|PubMed:27611567}.
Interaction partners:
Sequence:
MASHTLRPHRSPSPSPEPPVNLANPAKLTRQSLGPPTSGNSKGFGSLGLGPGLASPSSPSQPRHVSSSVAMGMGNRDSLSPRPSGVGSGRAVSATTGPRPSSEFIPTREAKTPEAEQIDQWFKHLANWEATLEEMAAASTDQNFTEELGAIEQWFRVLSEAERTAALYSLLQYSTPVQIRFFISVLHHMSQSDPMSALLSPSLSGSNAFQTQVESKLSNMNLKSPSAGGGAGFAGSSGNGHYLAPDDAAAKAAKARQNRISAPGTLQPHDRWQGQLDQVVERGTSPGLESNMSGRSRSKSPTPEPRPKSTDFSGKPRESLRRESAAFPRSPRVSAGSPGIGLGIGHESPMASPFGNNASWASMVNTPLVQNFNDGKLVAPASVADLSQALNMATLQLNNPGYLPLDDARKYRRPTGGLASGQTSRNVSGQYNDDGEIVNPHTTQPGTPSGLLPNQFGGGRSPLVDQFGLGGLGIGADSTTLANLGLNYNLAGLGGVNPGLNGLTAAQAQAAQMLAMQQQLQNSQYSPFNASAPSLQPGLNPSRRGAGRGQSSHLNQHYNQHQQQHQPGRRSPNPLKSHSPAPGQQTGGGGAGGGAGVAGPEDVDVKVLEDVPNWLRVLRLHKYTPNFEKSNWNDMVLMTDQDLQDNGISAQGARTKFLKVFYNVRTKMDIAHPPGQEEYAPGPKESK
Protein: DNA-3-methyladenine glycosylase 1 (EC 3.2.2.20) (3-methyladenine-DNA glycosylase I, constitutive) (TAG I) (DNA-3-methyladenine glycosidase I) (DNA-3-methyladenine glycosylase I) (P05100)
Organism: Escherichia coli (strain K12)
Function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions.
Interaction partners:
- DNA-3-methyladenine glycosylase 2
- Peptidyl-lysine N-acetyltransferase YiaC
- NADP-dependent 3-hydroxy acid dehydrogenase YdfG
- GMP synthase
- Methylated-DNA--protein-cysteine methyltransferase
Sequence:
MERCGWVSQDPLYIAYHDNEWGVPETDSKKLFEMICLEGQQAGLSWITVLKKRENYRACFHQFDPVKVAAMQEEDVERLVQDAGIIRHRGKIQAIIGNARAYLQMEQNGEPFVDFVWSFVNHQPQVTQATTLSEIPTSTSASDALSKALKKRGFKFVGTTICYSFMQACGLVNDHVVGCCCYPGNKP
Protein: Proteasome subunit beta type-7 (EC 3.4.25.1) (Q54QR2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-6
- Proteasome subunit beta type-2
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-1
Sequence:
MENLNRGGFDFDLCNRNNVLEKTGLRMKGFMKTGTTIVGVVYKGGVVLGADTRATEGPIVADKNCEKIHYIADNIYCCGAGTAADTESATALISSKLKLHKLSTGKQTRVITALTMLKQMLFKYQGHISAALILGGIDINGPSLHTIYPHGSTDQLPYVTMGSGSLAAMAVFEAKYKNDMTKEEAIALVAEAISSGIFNDLGSGSNVDVTVIEPSGVTVLRNYQTPNERKFRNNPYIFKQGTTPVLKQDIAPLSTKVVIEDIMMGQ
Protein: Angiogenin ribonuclease 2 (Angiogenin, ribonuclease A family, member 2) (Ribonuclease A a2) (Q5GAM5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MEMSLRPLLLVFVLSLVATPSTLAQDDPRYTKFLTQHYDAKPKGRDARYCESMMKRRGLTSPCKEVNTFIHGNKGSIKAVCGANGSPYGENLRISQSPFQITTCKHTGGSPRPPCRYRASAGFRHVVIACENGLPVHFDESFISLYSAGPRRRPSSVLFLSPLTPEH
Protein: Immune-associated nucleotide-binding protein 2 (AtIAN2) (AIG1-like protein) (Q9C8U5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGTSVSKPVSDDKKKGTSVSKPVKNIVLVGRSVNGICTTGNNILGQNKFGSEGAFMHCQMYSTTTPDGQMINVIKTPGMFDLSVSEDYISKEIINCLTLAEEGVHAVLFVLSMKNRITQEEEYALNTLQRIFGSKILEYLIFLLIDGEKFEAKEFEDYFPECCPEFLMRVLRFCNGRKVLFNNMTNDEGVKAEQVNQVMAHVAAISKKNDEKPYTEDMYRNIKVNTFFSLIAFI
Protein: Hyaluronidase-4 (Hyal-4) (EC 3.2.1.35) (Chondroitin sulfate endo-beta-N-acetylgalactosaminidase) (Chondroitin sulfate hydrolase) (CSHY) (Hyaluronoglucosaminidase-4) (Q05A56)
Organism: Mus musculus (Mouse)
Function: Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Beta-glucuronidase
- Alpha-L-iduronidase
- Arylsulfatase B
Sequence:
MQLLPEGQLRLCVFQPVHLTSGLLILFILKSISSLKPARLPVYQRKPFIAAWNAPTDLCLIKYNLTLNLKVFQMVGSPRLKDRGQNVVIFYANRLGYYPWYTSEGVPINGGLPQNTSLQVHLKKAAQDINYYIPSENFSGLAVIDWEYWRPQWARNWNTKDIYRQKSRTLISDMKENISAADIEYSAKATFEKSAKAFMEETIKLGSKSRPKGLWGYYLYPDCHNYNVYATNYTGSCPEEEVLRNNDLSWLWNSSTALYPAVSIRKSFADSENTLHFSRFRVRESLRISTMTSQDYALPVFVYTQLGYKEEPLLFLSKQDLISTIGESAALGAAGIVVWGDMNLTSSEENCTKVNRFVNSDFGSYIINVTRAAEVCSRHLCKNNGRCVRKTWKAAHYLHLNPASYHIEASEDGEFIVRGRASDTDLAVMAENFLCHCYEGYEGADCREMTEASGPSGLSLSSSSVITLCLLVLAGYQSIQL
Protein: Inhibitor of growth protein 1 homolog (Q54PN9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in regulation of the growth and differentiation transition (GDT) process, probably by regulating gene expression via histone modification.
Subcellular location: Nucleus {ECO:0000255|RuleBase:RU361213, ECO:0000269|PubMed:16003496}.
Interaction partners:
- Chromatin modification-related protein EAF6
- Probable transcription-associated protein 1
- Myb domain-containing protein
Sequence:
MYQGKGTYLENYLDSISTLPSELGRNFALIRELDYRTSDLVEKIEKLKSNLLVTTNGTRRAVHELTDERASKHIKLEMKQVIEYSDEKVELSNQTYELIDKHIRKLDIDLKKFETELESAEEEKKKKKSKQSQNNSTVESSTTSSSSSSSSSSLSLSSSTNNTSSLNSSSGGGGGGSGGGGGGGGHSSHSTGNKKGKARDSLTSSSSSGNINGMSSSSSSSSSSSSLSSRKQKSMAAQDIASITGNNGDADVRVFNANPNDLDLAIDPNEPTYCFCNRVSFGEMVGCENPDCKIEWFHFECVGLTSTPKGKWYCPDCTRIKVKK
Protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (mmVIP2) (Q6ZQB6)
Organism: Mus musculus (Mouse)
Function: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Required for normal hearing.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O43314}.
Interaction partners:
- Inositol hexakisphosphate kinase 3
- Inositol hexakisphosphate kinase 1
- Inositol hexakisphosphate kinase 2
- Inositol-pentakisphosphate 2-kinase
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Sequence:
MSNSRKMSEPPRFFVGPEDAEINPGNYRRFFHHAEEEEEEEDESPPERQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEEIILNEPVENWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRRDVYSILQAEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLMELGQNNDSEIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDNRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISVIKSMHLIKNPVKTCDKVYSLIQSLTSQIRYRMEDPKSADIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCDDSKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRPASRENEGRRSLKTDDDEPHTSKRDEVDRAVMLFKPLVSEPIHIHRKSPLPRSRKITANEVVSENANYLRTPRNLVEQKQNPTVGFELYSMVPSICPLETLHNALFLKQVDDFLASIASPSTEVLRKVPEMSSMATRSSPGMRRKISLNTYTPTKILPTPPAALKSSKASSKAAAGGPSQAMAPHTSSRKKSINSKTEGHEPKKSTGKKR
Protein: Transcription factor 12 (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) (B4DGI9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGTIHEMKQLNSKARQKGQRIKGFTDSPHYSDHLNDSRLGAHEGLSPTPFMNSNLMGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPLHDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACL
Protein: Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (Common component for nitrate reductase and xanthine dehydrogenase protein H) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) (Q9Y8C1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03052}.
Interaction partners:
- Adenylyltransferase and sulfurtransferase uba4
- MoaB/Mog domain-containing protein
- Molybdopterin synthase sulfur carrier subunit
- Radical SAM core domain-containing protein
- SAGA complex component
- molybdopterin adenylyltransferase
- Rhodanese domain protein
- Nitrate reductase
- Ubiquitin-like modifier-activating enzyme atg7
- NEDD8-activating enzyme E1 catalytic subunit
Sequence:
MSARPEPQPGSERNATEPLPSHLDPTTYPRTLTTTHGPTSIPLHLELTYHTLSPTTALQHVSSPSSGANILFLGTTRDTFDDRPVARLSYTSYPALALKSLHKISSEAVEKFGLNGVYIAHRLGEVPVGEASIVVAVGAGHRGEAWRGAEWVLEVVKERVEVWKREEFVDGGMEWRENRERDGFGKLKTKKEDSR
Protein: Transcription factor ORG2 (Basic helix-loop-helix protein 38) (AtbHLH38) (bHLH 38) (OBP3-responsive gene 2) (Transcription factor EN 8) (bHLH transcription factor bHLH038) (Q9M1K1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
- Ferric reduction oxidase 2
- Transcription factor bHLH47
- Fe
- Transcription factor ILR3
- Transcription factor bHLH34
- Transcription factor bHLH104
- Transcription factor bHLH115
- Probable nicotianamine synthase 4
- Transcription factor ORG3
Sequence:
MCALVPSFFTNFGWPSTNQYESYYGAGDNLNNGTFLELTVPQTYEVTHHQNSLGVSVSSEGNEIDNNPVVVKKLNHNASERDRRKKINTLFSSLRSCLPASDQSKKLSIPETVSKSLKYIPELQQQVKRLIQKKEEILVRVSGQRDFELYDKQQPKAVASYLSTVSATRLGDNEVMVQVSSSKIHNFSISNVLGGIEEDGFVLVDVSSSRSQGERLFYTLHLQVENMDDYKINCEELSERMLYLYEKCENSFN
Protein: Ornithine aminotransferase (EC 2.6.1.13) (A0A140VJQ4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF
Protein: Transcription factor HES-2 (Class B basic helix-loop-helix protein 40) (bHLHb40) (Hairy and enhancer of split 2) (Q9Y543)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW
Protein: Homeotic protein ultrabithorax (JcUbx) (Q8T940)
Organism: Junonia coenia (Peacock butterfly) (Precis coenia)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:7840822}.
Interaction partners:
Sequence:
MNSYFEQGGFYGAHGVHQGGGGGDQYRGFPLGLTYAQPHALHQPRPQDSPYDASVAAACKLYAGEQQYAKADCSKAGGEQQNGYGGKEAWGSGLGALVRPAACTPEARYSESSSPGRALPWGNQCALPGAAASAQPVQHQPTNHTFYPWMAIAGANGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQAQKAAAAAAAAAAAAQGHPEH
Protein: Receptor-like protein 44 (AtRLP44) (Q9M2Y3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Pectinesterase inhibitor 5
Sequence:
MTRSHRLLLLLLLIFQTAQRLTTADPNDEACLKNLRQNLEDPASNLRNWTNSVFSNPCSGFTSYLPGATCNNGRIYKLSLTNLSLRGSISPFLSNCTNLQSLDLSSNQISGVIPPEIQYLVNLAVLNLSSNHLSGEITPQLALCAYLNVIDLHDNELSGQIPQQLGLLARLSAFDVSNNKLSGQIPTYLSNRTGNFPRFNASSFIGNKGLYGYPLQEMMMKSKGLSVMAIVGIGLGSGIASLMISFTGVCLWLRITEKKIVEEEGKISQSMPDY
Protein: Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) (Q32LQ4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Methylenetetrahydrofolate reductase
- S-adenosylmethionine synthase
- S-adenosylmethionine synthase
- S-adenosylmethionine synthase
- Adenosylhomocysteinase
- S-adenosylmethionine synthase
- Cystathionine beta-synthase
- Cystathionine gamma-lyase
- Cystathionase
- Cystathionine beta-synthase
Sequence:
MAPVGSKRGVLERLNAGEVVIGDGGFVFALEKRGYVKAGPWTPEAAAEHPEAVRQLHREFLRAGSNVMQTFTFYASDDKLENRGNKLSFTGQQINEAACDLAREVANEGDALVAGGVSQTPSYLSCKSEEEVKKTFKKQLDVFIKKNVDLLIAEYFEHVEEAEWAVQVLKATGKPVAATLCIGPDGDMHGVIPGECAVRLVKAGADIVGVNCHFDPLTCVKTVAMMKAAVEKAGLKAHYMTQPLAYHTPDCSCQGFIDLPEFPFALEPRILTRWEMQQYAREAYKAGIRYIGGCCGFEPYHIRAVAEELSAERGFLPEASQKHGLWGSGLEMHTKPWVRARARRDYWEKLKPASGRPLCPSMSTPDGWGVTRGHAALMQQKEATTAEQLRPLFQQADAKH
Protein: dual-specificity kinase (EC 2.7.12.1) (H3BQG1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSKDPADQRPHPPFGSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR
Protein: ATP-dependent RNA helicase DED1 (EC 3.6.4.13) (DEAD box protein 1) (Defines essential domain protein 1) (P06634)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes. Has weak ATP-dependent affinity for dsRNA, but strong ATP-dependent affinity for ssRNA. Acts as a virus host factor involved in the replication of the MBV and the L-A viruses by promoting the negative-strand RNA synthesis. May be involved in recognition of the preinitiation complex and DNA binding of the RNA polymerase III and play a role in mRNA splicing.
Subcellular location: Cytoplasm.
Interaction partners:
- U1 small nuclear ribonucleoprotein A
- Protein NAM8
- ATP-dependent RNA helicase DBP1
- Eukaryotic initiation factor 4F subunit p150
- Eukaryotic translation initiation factor 4E
- Eukaryotic initiation factor 4F subunit p130
- ATP-dependent RNA helicase DHH1
- Pre-mRNA-splicing factor SNU114
- ATP synthase subunit beta, mitochondrial
- Polyadenylate-binding protein, cytoplasmic and nuclear
Sequence:
MAELSEQVQNLSINDNNENGYVPPHLRGKPRSARNNSSNYNNNNGGYNGGRGGGSFFSNNRRGGYGNGGFFGGNNGGSRSNGRSGGRWIDGKHVPAPRNEKAEIAIFGVPEDPNFQSSGINFDNYDDIPVDASGKDVPEPITEFTSPPLDGLLLENIKLARFTKPTPVQKYSVPIVANGRDLMACAQTGSGKTGGFLFPVLSESFKTGPSPQPESQGSFYQRKAYPTAVIMAPTRELATQIFDEAKKFTYRSWVKACVVYGGSPIGNQLREIERGCDLLVATPGRLNDLLERGKISLANVKYLVLDEADRMLDMGFEPQIRHIVEDCDMTPVGERQTLMFSATFPADIQHLARDFLSDYIFLSVGRVGSTSENITQKVLYVENQDKKSALLDLLSASTDGLTLIFVETKRMADQLTDFLIMQNFRATAIHGDRTQSERERALAAFRSGAATLLVATAVAARGLDIPNVTHVINYDLPSDVDDYVHRIGRTGRAGNTGLATAFFNSENSNIVKGLHEILTEANQEVPSFLKDAMMSAPGSRSNSRRGGFGRNNNRDYRKAGGASAGGWGSSRSRDNSFRGGSGWGSDSKSSGWGNSGGSNNSSWW
Protein: Protein LOW PHOTOSYNTHETIC EFFICIENCY 1, chloroplastic (Q9SNB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for light-regulated photosystem II (PSII) biogenesis and grana thylakoids formation by binding to the 5' UTR of PSII subunit mRNAs (e.g. psbJ, psbN and psbA) in a light-dependent manner through a redox-based mechanism, and facilitating the association of HCF173 with target mRNAs, which encodes PSII reaction center proteins (e.g. J, N and D1), thus regulating its expression by modulating ribosome loading.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:29891689}; Peripheral membrane protein {ECO:0000269|PubMed:29891689}; Stromal side {ECO:0000269|PubMed:29891689}. Plastid, chloroplast stroma {ECO:0000269|PubMed:29891689}. Note=Predominantly present at thylakoid membranes. {ECO:0000269|PubMed:29891689}.
Interaction partners:
- 11-beta-hydroxysteroid dehydrogenase-like 2
- Protein HIGH CHLOROPHYLL FLUORESCENCE PHENOTYPE 244
- Nucleotide binding protein
- Nucleobase-ascorbate transporter 8
- rRNA biogenesis protein RRP36
- Cytoplasmic tRNA 2-thiolation protein 2
- Nucleobase-ascorbate transporter 7
- Nucleobase-ascorbate transporter 1
- Uncharacterized protein At3g49140
- Protein BRI1-5 ENHANCED 1
Sequence:
MQALSILPLKSGLLVGSRLEFELDCSCFVVSPKTTRKRLCFLEQACFGSSSSISSFIFVSSNRKVLFLCEPKRSLLGSSFGVGWATEQRELELGEEEVSTEDLSSANGGEKNNLRVDVRELAFSLRAAKTADDVDAVLKDKGELPLQVFCAMIKGFGKDKRLKPAVAVVDWLKRKKSESGGVIGPNLFIYNSLLGAMRGFGEAEKILKDMEEEGIVPNIVTYNTLMVIYMEEGEFLKALGILDLTKEKGFEPNPITYSTALLVYRRMEDGMGALEFFVELREKYAKREIGNDVGYDWEFEFVKLENFIGRICYQVMRRWLVKDDNWTTRVLKLLNAMDSAGVRPSREEHERLIWACTREEHYIVGKELYKRIRERFSEISLSVCNHLIWLMGKAKKWWAALEIYEDLLDEGPEPNNLSYELVVSHFNILLSAASKRGIWRWGVRLLNKMEDKGLKPQRRHWNAVLVACSKASETTAAIQIFKAMVDNGEKPTVISYGALLSALEKGKLYDEAFRVWNHMIKVGIEPNLYAYTTMASVLTGQQKFNLLDTLLKEMASKGIEPSVVTFNAVISGCARNGLSGVAYEWFHRMKSENVEPNEITYEMLIEALANDAKPRLAYELHVKAQNEGLKLSSKPYDAVVKSAETYGATIDLNLLGPRPDKKNRP