Protein: Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) (Q14BN4)
Organism: Homo sapiens (Human)
Function: May play a role during myoblast fusion.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P0C219}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P0C219}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q3URD3}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q3URD3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q3URD3}. Note=Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum (By similarity). Detected along the Z- and M-lines in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P0C219, ECO:0000250|UniProtKB:Q3URD3}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}. Mitochondrion membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}. Mitochondrion membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}.; SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}. Mitochondrion membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}.; SUBCELLULAR LOCATION: [Isoform 4]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}. Mitochondrion membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}.; SUBCELLULAR LOCATION: [Isoform 5]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}. Note=Do not localize at the mitochondrial membrane. {ECO:0000269|PubMed:19538755}.
Interaction partners:
- Suppressor of IKBKE 1
- Striatin-interacting protein 1
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- MOB-like protein phocein
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Striatin-3
- Programmed cell death protein 10
- Serine/threonine-protein kinase 25
- Serine/threonine-protein kinase 24
- Striatin
Sequence:
MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQVRLEHLQEKTLKECSSLEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNNKPWPWMPMLAALVAVTAIVLYVPGLARASP