wanglab/gogpt-training-data huggingface dataset:
Protein: Mst2 complex subunit nto1 (O74759)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000305|PubMed:16823372}.
Interaction partners:
- Chromatin modification-related protein eaf6
- Pdp3-interacting factor 2
- Histone acetyltransferase mst2
- Pdp3-interacting factor 1
- PWWP domain-containing protein 3
- Histone acetyltransferase mst1
- PWWP domain-containing protein 1
- PWWP domain-containing protein2
- Probable chromatin modification-related protein eaf7
Sequence:
MQTFRLTSTGRNILRPDELAFQPREEIPYKSFHPDLQIDEPLEILEGDHTQYAGLRDSLVTYKSENSYVLKALLNAKIENVKPVGVQTENINPQEKKFGYKTAKQLDWSPDEYFKFVAIHPYSKTSFPVSYDLDELDTMWLTYYNEFQLSSNSEWENVSKEFLEIVLTIIEREWLYLEAWMPKIEPVRVEDELDGRCVICNEAECENSNAIVFCDNCNTSVHQNCYGIPFVPEGQWFCKKCLLAPHEVICCAFCPDRDGAFCTTLDGRWCHTICAIAIPEISFHDTSRLDLVRNIASIPKSRWKLVCCICKLRWGTCVQCSDKNCYAAYHITCARRAGFFYKIYSHSASYDSVDMETYCDKHTPPDYLNGLMKRLFPLAELYYKRMATDVPLNFQATKAPDFVPEGPWKSHPLPAFIVDKVTKVLLSYNVKRQDLPSIVTDICKFYHMKRRSRKDAPLLKSQLLMDSLENLPVRASKDRVRSLEVAKALQDQYQSLLTLVESTAKRQLLKCQLSNLRKKFLNLNYFPAQRLLQDTLVKIIDLDVDGLFNMPLDNGWIGWVELKRQVFSYQIGSISSLEKKLEPIWDVDGVIQCIDDMEQLTAMVQFAQKTEGEVKKLFIKAKIYFESLSLDERGNLKVPSLGINGLEYDNWPGLNELEMSQLDIPSQGNLKSLHDFIEGLDLNEKIGKFPISMFQNQVAQFSTIEIPKMSGRANGMHNFHSEDVTGQSNHALPNSVTKKNGTKQPYTKNSLPFNERITRSKAKKNYS
Protein: Ribonuclease P protein subunit rpr2 (EC 3.1.26.5) (RNA-processing protein rpr2) (Q9Y813)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable ribonuclease P protein subunit 1
- Ribonuclease P/MRP protein subunit POP5
- Probable ribonuclease P protein subunit 3
- Ribonucleases P/MRP protein subunit pop1
- Uncharacterized protein C6C3.09
- Probable ribonucleases P protein subunit pop8
- Ribonucleases P/MRP protein subunit POP7
- Ribonuclease MRP protein subunit rmp1
- Ribonucleases P/MRP protein subunit pop3
- Small ribosomal subunit protein eS12A
Sequence:
MSTKSKDQHARVSYLYQASQLLFRNVQEPTLSRHYISTAKDVSQKSVMRIHPDIKRTICKGCNSLLVPGKSCSIRFEEPSRKNPSIDRVLWICKKCAFKKRFSDKSC
Protein: Syntaxin-8 (Q9UNK0)
Organism: Homo sapiens (Human)
Function: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.
Subcellular location: Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity). {ECO:0000250}.
Interaction partners:
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Vesicle-associated membrane protein 8
- Syntaxin-7
- Vesicle-associated membrane protein 7
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Syntaxin-12
- Syntaxin-3
- Alpha-soluble NSF attachment protein
- Synaptobrevin homolog YKT6
- Vesicle-associated membrane protein 4
Sequence:
MAPDPWFSTYDSTCQIAQEIAEKIQQRNQYERKGEKAPKLTVTIRALLQNLKEKIALLKDLLLRAVSTHQITQLEGDRRQNLLDDLVTRERLLLASFKNEGAEPDLIRSSLMSEEAKRGAPNPWLFEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRNETRRVNMVDRKSASCGMIMVILLLLVAIVVVAVWPTN
Protein: Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33) (P20138)
Organism: Homo sapiens (Human)
Function: Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
Subcellular location: [Isoform CD33M]: Cell membrane {ECO:0000269|PubMed:10611343, ECO:0000269|PubMed:28747436}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform CD33m]: Peroxisome {ECO:0000269|PubMed:28747436}. Note=CD33m isoform does not localize to cell surfaces but instead accumulates in peroxisomes. {ECO:0000269|PubMed:28747436}.
Interaction partners:
- Low affinity immunoglobulin gamma Fc region receptor III-A
- Low affinity immunoglobulin gamma Fc region receptor III-B
- Triggering receptor expressed on myeloid cells 2
- Aminopeptidase N
- Hematopoietic progenitor cell antigen CD34
- Mast/stem cell growth factor receptor Kit
- TYRO protein tyrosine kinase-binding protein
- B-lymphocyte antigen CD19
- T-cell antigen CD7
- Alpha-
Sequence:
MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTHPTTGSASPKHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNPSKDTSTEYSEVRTQ
Protein: Cysteine-rich receptor-like protein kinase 6 (Cysteine-rich RLK6) (EC 2.7.11.-) (Receptor-like protein kinase 5) (Q9C5S9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Insecticidal crystal toxin domain-containing protein
- Copper ion binding protein
Sequence:
MSSLISFNFLFLFSFLTSSFTASAQDPFYLNHYCPNTTTYSSNSTYSTNLRTLLSSLSSRNASYSTGFQNATAGKAPDRVTGLFLCRGDVSPEVCRNCVAFSVNQTLNLCPKVREAVFYYEQCILRYSHKNILSTAITNEGEFILSNTNTISPNQKQIDGFTSFVSSTMSEAAGKAANSSRKLYTVNTELTAYQNLYGLLQCTPDLTRADCLSCLQSSINGMALSRIGARLYWPSCTARYELYPFYNESAIETPPLPPPPPPPPPRESLVSTPPISSSSLPGKSGNSTVLVVAVVVLAVLLFIALVGYCFLAKKKKKTFDTASASEVGDDMATADSLQLDYRTIQTATNDFAESNKIGRGGFGEVYKGTFSNGKEVAVKRLSKNSRQGEAEFKTEVVVVAKLQHRNLVRLLGFSLQGEERILVYEYMPNKSLDCLLFDPTKQIQLDWMQRYNIIGGIARGILYLHQDSRLTIIHRDLKASNILLDADINPKIADFGMARIFGLDQTQDNTSRIVGTYGYMAPEYAMHGQFSMKSDVYSFGVLVLEIISGRKNSSFGESDGAQDLLTHAWRLWTNKKALDLVDPLIAENCQNSEVVRCIHIGLLCVQEDPAKRPAISTVFMMLTSNTVTLPVPRQPGFFIQCRAVKDPLDSDQSTTTKSFPASIDDESITDLYPR
Protein: LD22928p (Methyl-CpG binding domain protein-like, isoform A) (Q9VHB7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSPTGKRAEGKPQDIAIPDFQPGKMPHCALPSPSISLYRCSAMPLPIASGGGNGATSGSAANALKRKFARSQGGNAAGAAGAAPPAATASSAATATAASASPSTANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Protein: Elongation factor G-like protein (P9WNM9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS12
- Elongation factor Tu
Sequence:
MADRVNASQGAAAAPTANGPGGVRNVVLVGPSGGGKTTLIEALLVAAKVLSRPGSVTEGTTVCDFDEAEIRQQRSVGLAVASLAYDGIKVNLVDTPGYADFVGELRAGLRAADCALFVIAANEGVDEPTKSLWQECSQVGMPRAVVITKLDHARANYREALTAAQDAFGDKVLPLYLPSGDGLIGLLSQALYEYADGKRTTRTPAESDTERIEEARGALIEGIIEESEDESLMERYLGGETIDESVLIQDLEKAVARGSFFPVIPVCSSTGVGTLELLEVATRGFPSPMEHPLPEVFTPQGVPHAELACDNDAPLLAEVVKTTSDPYVGRVSLVRVFSGTIRPDTTVHVSGHFSSFFGGGTSNTHPDHDEDERIGVLSFPLGKQQRPAAAVVAGDICAIGKLSRAETGDTLSDKAEPLVLKPWTMPEPLLPIAIAAHAKTDEDKLSVGLGRLAAEDPTLRIEQNQETHQVVLWCMGEAHAGVVLDTLANRYGVSVDTIELRVPLRETFAGNAKGHGRHIKQSGGHGQYGVCDIEVEPLPEGSGFEFLDKVVGGAVPRQFIPNVEKGVRAQMDKGVHAGYPVVDIRVTLLDGKAHSVDSSDFAFQMAGALALREAAAATKVILLEPIDEISVLVPDDFVGAVLGDLSSRRGRVLGTETAGHDRTVIKAEVPQVELTRYAIDLRSLAHGAASFTRSFARYEPMPESAAARVKAGAG
Protein: Cadherin domain-containing protein (Q8C924)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MADPPRRWICNDLLTFFMLLGTLCAPGKGQIRYSVREELDKGSFVGNISKDLGLEPRELAERGVRIISRGRSQLFSLNPRGGSLVTAGRIDREELCVQSSPCLVSFNILVENKMKIYGVEVEILDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDGDVGVNSLQGYKLSSNRHFSLDVKSGSDGQKHPELVLEQPLDREKESAHDLVLTALDGGNPVLSSTVHISVTVLDANDNAPLFTQSEYRVSVPENTPVGTRLLTLTATDADEGINAKLTFSFRNEEDKISETFQLDSNLGEISTIQSLDYEESRFYLMEVVAQDGGALLASAKVLVTVQDVNDNAPEVILTSLTSSVSEDCLPGTIIALFSVHDADSGENGEISCSIPKNLPFKLEKSVDNYYHLLTTRALDREETSDYNITVTVVDRGTPPLSTENHISLKVADINDNPPTFSRPFYSTSISENNPRGVSIFSVYAYDADSGDNAQVTYSLAENTFQEVPVSSYVSINSDTGVLYALQSFDYEHLRDLQLLVTAKDSGTPPLSSNVSMSLFVLDQNDNIPEILYPTIPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSIGLHTGEVCTARALLDRDVLKQSLVVAVQDHGQPPLSATVTLTIAVGDSIPDVLTDLGNHNTLAEPQDSDLTLYLVVSVAVVSCVFLGFVTVLLALRLRHWHMSRLLQTSTGRLADMPASHFVGMDGVQAYLQTYSHEISLTTDSKKSHLIFPQPNYADRLISEESCEKSEPLLIPHN
Protein: LD02979p (Ran binding protein 3, isoform A) (Q9VCI7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Exportin-1
- Nuclear pore complex protein Nup214
- Ran GTPase-activating protein
- Ran-binding protein 16
- Mothers against decapentaplegic homolog
- Nuclear pore glycoprotein p62
- Regulator of chromosome condensation
- E3 SUMO-protein ligase RanBP2
Sequence:
MSENNEASVETNCFRGGFTLKASRLGGAVLRPAVLANSSGSNNSSTSPSAGEDSALLNNPFLRESKDDDDDEEVVATGSAAAESTGDKEDDDVDERPDPLTKLRSNGIERSSMFAAAKNNMPNVQSSGFVFGQNVHERVVAPNAEQVTAEPDADTAASSVSAQEAASSSTAATSSSAPLLFSSVIQNAAQTTETSEAAASSSICSSSSNNKESAEAKSLTDVAREYEESRAQKRKYEEVETFTGEEDEINIIDVSCKLFAFLNSNWEERGRGSLRLNDAKDLRGDSRVVFRTSGNLRLLLNTKVWAAMVAERASQKSLRLTAIDNSGVVKIFLAMGRPADIAQLHKALSERIAKRKVSHPEECSVEEAKNGVASEAAASLQPESTTHDDEDEDAAPGPSGAISAEADSYGPSPKKVIVQPDSSADVPVPPVEEGDEDAEAEAKESTDQN
Protein: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.7) (B7Z9I1)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
MLQEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
Protein: GTPase-activating protein CdGAPr (d-CdGAPr) (Q9VIS1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably functions as a GTPase-activating protein (GAP) for RAC1 and/or CDC42. Required for optic stalk formation.
Interaction partners:
- FI17866p1
- Uncharacterized protein, isoform A
- FI17823p1
- RhoU, isoform B
- Serine/threonine-protein kinase Genghis Khan
Sequence:
MSDKVSTSLAAQLHSHALASAEAGGIGGVNGGPIACHASTDKDAQAPPLQFEMDAPAAAISAQLNFKIVPADSLPGLSYQDMFASMNTSQISNASTESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLDEMLHRCVYDRKISGLRNMEELAAELPSESDVEYAVAKYLERFSKIASDSLTCGTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPRNFPMPAPLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVEQREQDQSLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAASNIGSYIEVGGGPSSLPDKYHTVLSAPRSWQKRKPDKTPSWKSIFSRSQRQGNPDPGQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSVSHDSYFDLLQSPQRGHMTTCPSRELSELGLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFSSQTNSVNPSPKKQPRLNLLSPSSARTMPPPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDIQFIDCGTPENVPTTQQQFASVEVHPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKRKEQQDAKERFSYQGTFTQPGQKQESSAPRPVHSTNNGATLRKPRVEPVEDGQIKLHVPTPTTPARSPRYSLLLCDTESSDNSSAVNTPQYDMEPLMLTSAMSGVSGVSSNVQQQQLLLGVDASSSYLGSSHESLGQNINNHHDAEQRDMNALKRELSLDLNPLQPRLPQPANRAATLPVKDQLQAAAAAMCSSPNNSNFTDNTSQSVTPSEYGYQHLQRQLSMHSLLATDESSPVYEDFEQTPVKMVPSPIKSTISITYKSPEKEKKPSAILETNFDENTVYEQVKLFRNSVTEVNQMLHERSSLKQIAEEEQHDGGAYKAAEMTQQLLQLEQEHHDHEEQQEKEPEDEEQSQLLYENIELRKPKTVYENLRGEEMKFITEEQKPNVDRIELDSLDSLPDNMEHEQSSPSKSPTFSVKELANKFESSPVEQLPNFDFSVRGGSMKKPNELSVPKTMPAPVPLKKLNSSAQKITRSLDENAFVREFGGKQLQDLSLSNKLPEVMSEVNSRRKSFDFTRPKTLNPPKRLPGMSITEEICQKRVGEMEAITPTTENRISLIQQNNMPKEQQSSANQFLPPAGRKNVLTGVVLDRERIDKIKEERRQQLTQKYYGDTLKSRSRTELNSEDNFPAAESLRIKSKSRGDMHALQKDIDMNLKQLSRVTGGGSECTLHTGLSQGNGQEHLGQQRVRRISDEKNQNCDTSNGGVSGITSTSLLSVKTTAQKYGSTSKTPANKFERSQPMPRDRLQRNSLAESNAGTNNREKISPQFSIRDVTAMFESRSQNQ
Protein: Keratin-associated protein 21-1 (Keratin-associated protein 16-7) (Keratin-associated protein 16.7) (Q925H4)
Organism: Mus musculus (Mouse)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 6-2
- Keratin-associated protein 19-5
- Keratin-associated protein 16-3
- Keratin associated protein 20-1
- Glycine tyrosine-rich hair keratin protein
- Keratin-associated protein 19-3
- Keratin associated protein 22-2
- Glycine tyrosine-rich hair keratin protein
- Keratin-associated protein 19-9b
- Keratin-associated protein 5-1
Sequence:
MCCNYYGNSCGGCGYGSRYGYGCGYGSGYGCGYGSGYGCGYGSGYGCGYGSGYGCGYGSGYGCGYGSGYGCGYGSGYGCGYGSGYGCGYGSGYGCGYGSGYGCGYGSRYGCGYGSGCCSYRKCYSSCC
Protein: Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] (P13589)
Organism: Rattus norvegicus (Rat)
Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Pituitary adenylate cyclase-activating polypeptide type I receptor
- Vasoactive intestinal polypeptide receptor 2
- Vasoactive intestinal polypeptide receptor 1
- Glucagon-like peptide 1 receptor
- Gastric inhibitory polypeptide receptor
- Adrenocorticotropic hormone receptor
- D
- Beta-1 adrenergic receptor
- Thyrotropin receptor
- Adenosine receptor A2a
Sequence:
MTMCSGARLALLVYGIIMHNSVSCSPAAGLSFPGIRPEEEAYDQDGNPLQDFYDWDPPGAGSPASALRDAYALYYPADRRDVAHEILNEAYRKVLDQLSARKYLQSMVARGMGENLAAAAVDDRAPLTKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL
Protein: GH10594p (Q95U36)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLHGHGHHAHHHGGAVVIAGSGVGTGLGSGATSVIMQHQQQQQQQQNMHKKNSIRNGGDVLKRTRAQSAYELSQDLLEKQIELLERKYGGVRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAGPAGAASPGLSRTPPTRSLSMRERRQLDCSPIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENGSLTSVQSSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNEKPQRRGSVGSLDSGMSISFQSTTTSSASRENAAAIAAAANAAAAAKMRFNMPPTAAIATPSNVYAAPGMQAYTHANFVQQSQAAYMLQQQQMLQQQAQMQAQAQAQAQAQAQAQAQAQAQAQAQPLTGRIPGRERKASRTDENGRSTEV
Protein: DIS3-like exonuclease 1 (EC 3.1.13.1) (Q8TF46)
Organism: Homo sapiens (Human)
Function: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}.
Interaction partners:
- Exosome complex component RRP42
- Exosome complex component RRP41
- Exosome complex component MTR3
- Exosome complex component RRP46
- Exosome complex component RRP43
- Exosome complex component CSL4
- Exosome complex component RRP45
- Exosome complex component 10
- Exosome complex component RRP40
- Exosome complex component RRP4
Sequence:
MLQKREKVLLLRTFQGRTLRIVREHYLRPCVPCHSPLCPQPAACSHDGKLLSSDVTHYVIPDWKVVQDYLEILEFPELKGIIFMQTACQAVQHQRGRRQYNKLRNLLKDARHDCILFANEFQQCCYLPRERGESMEKWQTRSIYNAAVWYYHHCQDRMPIVMVTEDEEAIQQYGSETEGVFVITFKNYLDNFWPDLKAAHELCDSILQSRRERENESQESHGKEYPEHLPLEVLEAGIKSGRYIQGILNVNKHRAQIEAFVRLQGASSKDSDLVSDILIHGMKARNRSIHGDVVVVELLPKNEWKGRTVALCENDCDDKASGESPSEPMPTGRVVGILQKNWRDYVVTFPSKEEVQSQGKNAQKILVTPWDYRIPKIRISTQQAETLQDFRVVVRIDSWESTSVYPNGHFVRVLGRIGDLEGEIATILVENSISVIPFSEAQMCEMPVNTPESPWKVSPEEEQKRKDLRKSHLVFSIDPKGCEDVDDTLSVRTLNNGNLELGVHIADVTHFVAPNSYIDIEARTRATTYYLADRRYDMLPSVLSADLCSLLGGVDRYAVSIMWELDKASYEIKKVWYGRTIIRSAYKLFYEAAQELLDGNLSVVDDIPEFKDLDEKSRQAKLEELVWAIGKLTDIARHVRAKRDGCGALELEGVEVCVQLDDKKNIHDLIPKQPLEVHETVAECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSELRECAKAKGFFIDTRSNKTLADSLDNANDPHDPIVNRLLRSMATQAMSNALYFSTGSCAEEEFHHYGLALDKYTHFTSPIRRYSDIVVHRLLMAAISKDKKMEIKGNLFSNKDLEELCRHINNRNQAAQHSQKQSTELFQCMYFKDKDPATEERCISDGVIYSIRTNGVLLFIPRFGIKGAAYLKNKDGLVISCGPDSCSEWKPGSLQRFQNKITSTTTDGESVTFHLFDHVTVRISIQASRCHSDTIRLEIISNKPYKIPNTELIHQSSPLLKSELVKEVTKSVEEAQLAQEVKVNIIQEEYQEYRQTKGRSLYTLLEEIRDLALLDVSNNYGI
Protein: Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3) (Q9Y2Q5)
Organism: Homo sapiens (Human)
Function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Subcellular location: Late endosome membrane {ECO:0000250|UniProtKB:Q9JHS3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JHS3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JHS3}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JHS3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JHS3}. Note=Recruited to lysosome and endosome membranes by LAMTOR1. {ECO:0000250|UniProtKB:Q9JHS3}.
Interaction partners:
- Ragulator complex protein LAMTOR3
- Neutral amino acid transporter 9
- Ragulator complex protein LAMTOR5
- Ragulator complex protein LAMTOR1
- Ras-related GTP-binding protein B
- Ras-related GTP-binding protein C
- Ragulator complex protein LAMTOR4
- Ras-related GTP-binding protein A
- Regulatory-associated protein of mTOR
- Serine/threonine-protein kinase mTOR
Sequence:
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS
Protein: At1g07080/F10K1_15 (Interferon inducible-lysosomal thiol reductase) (Thioredoxin superfamily protein) (Q93VQ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MASMPSKLLPVLVCYVFLFPFASSSDYSGVSLPSSSPKVSVGLYYESLCPYCSSFIVNHLAKLFEDDLISIVDLHLSPWGNTKLRSDNVTAVCQHGAFECFLDTVEACAIDAWPKVSDHFPFIYCVEKLVTEHKYDKWETCYEKLNLNSKPVADCLSSGHGNELALHYAAETNALQPPHKYVPWVVVDGQPLYEDYENFISYICKAYKGNKVPGACTKYATGNFIRSVKLKRSPLVSWKGVNKMWDVLERITTSLSSYIDITGLL
Protein: Pyruvate kinase (EC 2.7.1.40) (D3YT36)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSLHSSSEHSSATTNISHLCGLRISERPQKTRKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNMKEVQLENGKSVRVSTDPSMEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYYPKGRIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIVVAT
Protein: Doublesex- and mab-3-related transcription factor 3 (Q9NQL9)
Organism: Homo sapiens (Human)
Function: Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
Sequence:
MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAVAAPQPPPASQPSQPQPPRPAAELAAAAALRWTAEPQPGALQAQLAKPDLTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVSVEEGGYAVQKNGGNPESRPDSPKCHAEQNHLLIEGPSGTVSLPFSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSVTGAERTSAEPESLALPSNGHIFEHTLSSYPISSSKWSVGSAFRVPDTLRFSADSSNVVPSPLAGPLQPPFPQPPRYPLMLRNTLARSQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSSPVLPARATEDPRISIPDDGCPFVSKQSIYTEDDYDERSDSSDSRTLNTSS