wanglab/gogpt-training-data huggingface dataset:
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q582V4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004585}.
Interaction partners:
- Peroxisome assembly protein, putative
- Nonspecific lipid-transfer protein, putative
- propanoyl-CoA C-acyltransferase
- Peroxisome targeting signal 1 receptor
- Peroxin-13
- Peroxisomal membrane protein PEX14
- Peroxin 19
- Peroxin-7
- Peroxisomal ATPase PEX1
- Peroxisomal ATPase PEX6
Sequence:
MQPATAPYLLRSLYKDDHIISTHLNRQITNIVTALFGAHTTNCYDAQLCYLAKGIYVAFALLRGQTLGQEFCDLLPVTGSNPPRLVGMRRKLLLATFLALEPAVVFQFAVRLFPRLPPHDVVSNVSKCTLMMLMLLETYGTLAHRFLRVRYLSLVPSGALQNGEGAPRTYLKLGFVLMLELLIRLWRAVAEWRGNRGAGEQNEQGGAAGRGEDDSDTADEHASVSGKCMLCLGNRKQPTATLCGHIFCWRCLSEWIKSNTQGAICPFCRRRITVNSLVPLYFYVAKEPPVADGDSGAS
Protein: DUNC-115l (SD01878p) (Uncoordinated 115a, isoform A) (Q9VH91)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGKQKIYCAKCTKKCSGEVLRVADNHFHKACFQCCQCKKSLATGGFFTKDNAYYCIPDYQRLYGTKCANCQQYVEGEVVSTMGKTYHQKCFTCSKCKQPFKSGSKVTNTGKEVLCEQCVTGAPVSPSRQATGGGVSSPAPPAESPTRATAHQQHGSVISHKAHLKEDYDPNDCAGCGELLKEGQALVALDRQWHVSCFRCKACQAVLNGEYMGKDAVPYCEKCYQKGFGVKCAYCSRFISGKVLQAGDNHHFHPTCARCTKCGDPFGDGEEMYLQGSAIWHPRCGPGPSESGIILNGGGGTSSVVGGASNGNFTDTECDRMSSSALSEMYIRSRTPSFNGSLYSSSRKHYRTVSPGLILREYGRPNAEDISRIYTYSYLTDAPHYLRKPIDPYDKTPLSPHFHRPSSYATTASNAGSVAGSRPPSRPHSRTRSAMKVLVDAIRSETPRPKSPGMNNEEPIELSHYPAAKKPPPGEQPKIERDDFPAPPYPYTDPERRRRYSDTYKGVPASDDEDENVENGKPNGKVKNGEEQQRLQREAEQLEKLNSGIGSAIAKDLKEHAKYRKWKQNNLDPRNASRTPSASKEPLYKLRYESPIGASPSRNLDHQKPFYEDEMFDRSTSYRGSLGKSLGNAPSYNAIHSYRSPPKPGYGFKTTTLPYIRNGFSSDFSYGGLGDKTHSTDLSCGKSEASVDSITEGDRRALMGGDLPASSTYSGALSYHYPQAGLIRRSLPNMSHSMLVHEPAKIYPYHLLLITNYRLPSDVDRCNLERHLSDIEFEHILQCARSEFYRLPQWRRNELKRRVKLF
Protein: Conserved alanine valine rich protein (O05854)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- RNA helicase
- Possible SOJ/para-related protein
- PE-PGRS family protein PE_PGRS7
- ORC1/DEAH AAA+ ATPase domain-containing protein
- Conserved protein
- PE-PGRS family protein PE_PGRS4
- Probable conserved lipoprotein LppL
- Probable conserved transmembrane protein
- Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW
- Probable conserved integral membrane protein
Sequence:
MVKPERRTKTDIAAAATIAVVVAVAASLIWWTSDARATISRPAAVAVPTPAPAREVPTSLKQLWTAASPATRVPVVVGGTVATGDGRQVDGRDPATGESLWSYARDTDLCGVTWVYHYAVAVYRYDRGCGQVSTIDGSTGRRGAARSGYADPRVRLFSDGTTVLSAGDTRLELWRSDMVRMLAYGEIDARVKPSNRGLQSGCTLESAAASSAAVSVLEACTNQADLRLVLLRPGKEDDEPIQRIVPEPGVRPGSGARVLVVSQNNTAVYLPARSGAQPRVDVIDETGATVSSTLLAKPPSTSAVASRTGNLVTWWTGDALLVFDAGNLTQRYTIAAGETTAPVGPGVMMAGQLLVPVTGGIGVYDPVSGANNRYIPVTRPPSTSAVIPAVSGSRVIEQRGDTLVALG
Protein: 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) (Ketopantoate hydroxymethyltransferase) (KPHMT) (P31057)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Pantothenate synthetase
- Aspartate 1-decarboxylase
- 2-dehydropantoate 2-reductase
- Branched-chain-amino-acid aminotransferase
- Dihydroxy-acid dehydratase
- Coenzyme A biosynthesis bifunctional protein CoaBC
- Ketol-acid reductoisomerase
- Ribosomal RNA small subunit methyltransferase I
- PanD regulatory factor
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Sequence:
MKPTTISLLQKYKQEKKRFATITAYDYSFAKLFADEGLNVMLVGDSLGMTVQGHDSTLPVTVADIAYHTAAVRRGAPNCLLLADLPFMAYATPEQAFENAATVMRAGANMVKIEGGEWLVETVQMLTERAVPVCGHLGLTPQSVNIFGGYKVQGRGDEAGDQLLSDALALEAAGAQLLVLECVPVELAKRITEALAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIRAAVRQYMAEVESGVYPGEEHSFH
Protein: FERM domain-containing protein 3 (Q9D7M6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAKCLVKIRTQRSLHLHMMNHCSSNVFVRLLKHGSKVIPRNAGAPLSKVDASEHMVASSPVKGAQSAGSPRKEEDKVKEDPLILSELAYNTSASLLPTQVDDDEVDMLFDCPSRFVLEREDTDTFEDVEADENVFLMAEEEKVREAHQALSWSYSILTGRIWLNPLVKRCSRLLVVGLGLLLFVFPLVLLLLESVPVSMP
Protein: Trihelix transcription factor ASR3 (Protein ARABIDOPSIS SH4-RELATED3) (Q8VZ20)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that binds DNA and plays a negative role in regulating microbe-associated molecular patterns-(MAMPs, e.g. flg22, elf18, chitin, and LPS) triggered immunity (PTI) by negatively regulating immune gene expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:25770109}.
Interaction partners:
- Mitogen-activated protein kinase 4
- Homeodomain-like superfamily protein
- Trihelix transcription factor GTL1
- Guanosine nucleotide diphosphate dissociation inhibitor 2
- Guanosine nucleotide diphosphate dissociation inhibitor At5g09550
- Guanosine nucleotide diphosphate dissociation inhibitor 1
- Transducin family protein / WD-40 repeat family protein
- Vacuolar protein sorting-associated protein 45 homolog
- Trihelix transcription factor GT-3a
- F18C1.6 protein
Sequence:
MALEQLGLGVSAVDGGENSSAPSNDGGDDGVKTARLPRWTRQEILVLIQGKRVAENRVRRGRAAGMALGSGQMEPKWASVSSYCKRHGVNRGPVQCRKRWSNLAGDYKKIKEWESQIKEETESYWVMRNDVRREKKLPGFFDKEVYDIVDGGVIPPAVPVLSLGLAPASDEGLLSDLDRRESPEKLNSTPVAKSVTDVIDKEKQEACVADQGRVKEKQPEAANVEGGSTSQEERKRKRTSFGEKEEEEEEGETKKMQNQLIEILERNGQLLAAQLEVQNLNLKLDREQRKDHGDSLVAVLNKLADAVAKIADKM
Protein: Protein adenylyltransferase NmFic (EC 2.7.7.108) (AMPylator NmFic) (Q7DDR9)
Organism: Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
Function: Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins.
Interaction partners:
Sequence:
MPSENPIGKTMKSIDEQSLHNARRLFESGDIDRIEVGTTAGLQQIHRYLFGGLYDFAGQIREDNISKGGFRFANAMYLKEALVKIEQMPERTFEEIIAKYVEMNIAHPFLEGNGRSTRIWLDLVLKKNLKKVVNWQNVSKTLYLQAMERSPVNDLELRFLLKDNLTDDVDNREIIFKGIEQSYYYEGYEKG
Protein: Shrew (Q9VZE5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Protein screw
Sequence:
MKTLLTIYILLSFGELGLANMAQMRKKSHTEEFEGMPALFRAMSSSPNDGYTYNWSVVSFSTNGKPGSGLNCTVLYLDQCTSWNKCRQTCLKTGATSYRWFHDGCCECVGELCMNYGVNESRCRLCPEPGLEDEDD
Protein: HL05936p (Q7KLX0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
FGFVCSRKLQISMSDPGSAGYNITKDPALAKSRIFLGNLPVCTREELVSICQPYGKVLGSMVQKNYGFVQFETEELANKAASALHKSTFKQNMLTVRNASIKSKAANAIAKRNSNQGGQVTVQGGLVMSAAAAAAGQPLINDCEIIVQNRENTKYAEYIEERLKNSSLRVDVLFPNEDVLLGKVLANISSRGCLYAVLVTPQHEEHNSITVNILYGVPAEHRNMPLEDAITLISTDFRLKKQRDAVVLPPSTSIHKGQRRHPQEMQGLLERLADNHPLTASQYEVILKYLEGEREEQLKREVGEANALAKLKAPDPEIELQKKILSIMNKPAVTDVTSELMYPTFEAVKEDRRLMELLADDRVLAALESVYNSDLRQILAEYL
Protein: Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2) (P53792)
Organism: Rattus norvegicus (Rat)
Function: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q923I7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31639}.
Interaction partners:
- Dipeptidyl peptidase 4
- Glucagon-like peptide 1 receptor
- Pro-glucagon
- Insulin-1
- Insulin-2
- PDZK1-interacting protein 1
- Sodium-dependent phosphate transport protein 2A
- Solute carrier family 2, facilitated glucose transporter member 2
- Renin
- Sodium/hydrogen exchanger 3
Sequence:
MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRDPVTGGLPWPALLLGLTIVSGWHWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLLMGLARLIPEFFFGTGSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTLAISRCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQSPAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMTVAVFLWGFYA
Protein: Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (Hypusine-containing protein HP2) (eIF-4D) (P23301)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Essential for polarized growth, a process necessary for G1/S transition. May mediate large range of effects of the polyamine spermidine in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10229683, ECO:0000269|PubMed:11861547}. Note=Concentrates in the perinuclear region. {ECO:0000269|PubMed:11861547}.
Interaction partners:
- Deoxyhypusine synthase
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein eL30
- Small ribosomal subunit protein uS15
Sequence:
MSDEEHTFETADAGSSATYPMQCSALRKNGFVVIKSRPCKIVDMSTSKTGKHGHAKVHLVAIDIFTGKKLEDLSPSTHNMEVPVVKRNEYQLLDIDDGFLSLMNMDGDTKDDVKAPEGELGDSLQTAFDEGKDLMVTIISAMGEEAAISFKEAARTD
Protein: Probable cell wall mannoprotein PIR32 (Q59PW0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Probable structural component of the cell wall involved in cell wall integrity and virulence.
Subcellular location: Secreted, cell wall {ECO:0000305}.
Interaction partners:
Sequence:
MIHYLIFPILLIFFQIIKSSGYYVPANGDDWTILKPPSCKNKLPGQYIDSLPFTFGIVVNPYILNEDGDYEKPIVSKIKPSLTTTTFVTSIITTSTATAPGSKPTKTKDIIVQIHDGQVQKMKHKHDYSSGGGDDDDDDEDCFDEKNIDMAAKRDYQDMNTQEQANEDSGQVLAESDSHQQVVDQNQQINEEEEETQEQQMQEENNNTNEIEDNKVQEFETIEEIYDDIDNNESRPNNSKKYHKKRPHNNYENKHGHKDYHEDHHHNHRYKDHENGHEEDDHKWNKPKPMPEQEEQEQEQEQKPKHEKSEGYESEFVSPVYSVACYTNSTLKMTLTDGILRDSDDRIGCIVSGHQFQFDGPTPQHGAIYAAGWSVTKQGQLALGDSTKFYQCASGDFYNLYDEPIAFQCHPVTLDVVELIEC
Protein: PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) (A5PKW4)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:23603394}. Cell projection, ruffle membrane {ECO:0000269|PubMed:23603394}. Cleavage furrow {ECO:0000269|PubMed:23603394}. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In later cytokinesis phases, fades away from the cleavage furrow and becomes uniformly distributed throughout the plasma membrane. {ECO:0000269|PubMed:23603394}.
Interaction partners:
- ADP-ribosylation factor 6
Sequence:
MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSGRRKP
Protein: Ribosome biogenesis protein NSA1 (NOP7-associated protein 1) (P53136)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the biogenesis of the 60S ribosomal subunit.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Nucleolar complex protein 2
- rRNA-processing protein EBP2
- Pescadillo homolog
- 25S rRNA
- Protein MAK16
- Ribosome biogenesis protein 15
- ATP-dependent RNA helicase HAS1
- Ribosome biogenesis protein RLP7
- Eukaryotic translation initiation factor 6
- Proteasome-interacting protein CIC1
Sequence:
MRLLVSCVDSGSIKEVLCNIGTDTSVQSALQPFHVAPHLAEGLKAYVDRMWVISEDEAILARNSGVVELVKISKHLKENEALQVDPKGESKNEKSLSDDLPKFDISEFEITSSVSDLFDDAKLESLSSKSVKRTKLVDGFVTLCPIKKDSSNNTFVAATKSGLLHIIKKGEDKKLIKLASLGLKAPVEFLQLYDLEDTDTDKYIFAYGGEENLIKLVEIDSSFQSLKQIWEAKNVKNDRLDMRVPVWPMALRFLEPSPGKTEKGKLNYQFAAITRWSHLTKYSTQHGRKPFAQIDLLPNREPLSQMEVFDAKGENVVSSLGNFQSETFNELNVITTDYKKNVFKFDGNGRMLGKVGRDDITGSSTYIHVHDGKYLLQGGLDRYVRIFDIKTNKMLVKVYVGSRINFIVMLDDVEIEMPLSPSAKAAKGKQKRKVTELEEDADELWNKLEGKVAASKASKKSKI
Protein: Toll-like receptor 4 (Q6TS41)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Early endosome {ECO:0000256|ARBA:ARBA00004412}.
Interaction partners:
Sequence:
MIMSNGERMIFLSSIFILVNAGQGQECTELIKNKEYSCSGRNLTCIPGSLPFSVASLDFSFNFLTSLHKRVFPVMLNLQLLDLTRCYIRQIEKDAFYNVKNLMTLILTGNPITYLAPECLNSLYKLQRLVLVDVRLESLQLQINNLTKLQDLKVGTNCIQSMTLPSFMSTFKDFSLLDLHANNISIIRMDHTAVLREIGRNMTLILSRNPLIHIEPGAFKDVILRELHLLAAFISFNAQKECHKALTGLTVDKLFVGRYRMDEKIKVSVPDYLEGLCSINFNEIYLVQKEWSDSEMHLFRCMVNATKITIKKAYMNSMKHIPFHRLKELYLSDTGLSVVPFISHIPSLEKLVMKSPFPITFTGVSDLPLLQYVDLSGNMLILHECCSILFPRTPNIQYLNLSQNSEITFVNEPFSALDLLEVLDFHHTKLVIVFYFGFFKHLRNLKYLDISYTRVHFNTLTFQDLHNLTVLKMAGNSFSGDKLSYFLQNLTSLEVLDISQCGIEKVSMRSFTGTQKLRHLYLSRNKLMVLDFLTQPELTHLTSVYIDKNSITTIPLDVLQKLPMNLSEFDLSSNSIDCSCSQTDFILWIIQKQNILKQLENIRCKTFSANTDFKAIDFDIDYCVHKKRLTIVLSVICVTFVVVLAILLYKFWFYVQYCFILFSGYRSPGQQECSYDAFVIFSSYDEAWVMNELMENLENGVPPIQLCLHMRDFQAGKSIASNIIDEGIMGSRKIIVVVSQHFIDSSWCRFEFELAQSRFLMERNANIIIIILEDVAERKTKKVFGLHKHLKKNTYLKWSRDPLSNMRFWIRLRKAIVAT
Protein: cAMP binding protein (Q38B79)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein kinase A catalytic subunit isoform 2
- Protein kinase A catalytic subunit
- Protein kinase A catalytic subunit isoform 1
Sequence:
MTLIPQNPYRMSFSRCNNERKASIPLQPTNTNGGISADNTGVDLKAHRVTPFTTTFGRRHTLYGETEIREAKETLAKLFVPVAKLGMYRLRRSRLHKKNSELRSYTIDSIVQAYRSSNSIISTWPMDVLTLLAEGAQYHYLEDGEVIVYAREWYLSTGIIVVLFGEVQETLPKSEKNFTPNKTSGNIRHPERSVLCEQTVLCRDFAPSRLKAHGYADVAVIPARWVWDAINYTSMEPFAEGMLDSLRMTVAPLCESVLERTYFPTALTLRRSWLWSFFSAGERIRLARLMEVKVFCAGDTLFGEGDRNPYVYIIRRGAVRVVVCKEPILDFGPGAAFGEVSVIFDEPRCCHAIATCLCEVYCLHRRHIMKRLRKKAHVCDSVIGTALRRREQWLEDAKTRHVMSLTVLLGGVPCLSQATEKVRAAIAEKAKTVVLPPRQVLFKKGTLCDHLFIVGRGTLLMEGAEDTVATRTSTGFVGELFLHPHLWPTDVTSLTSVDGWMFHVDVVKDALDSINAREQAVDICRQGIELYRAQYGPESVMEPTPAPRKLGPARKGTTAFSSGAKQSNSLRQKGQPRSPSLPSTPRLVAVAKTTPVKEEPLEKFDWNAYAIEDKVALPSADTDESDKRSERQQTEHVIEAELGGQAGSLLSAGVGLGISAIDCDFSDEVDEMRQMLLEQALLIPSNRLLFFLRQINRSKVTLVVDDGAVVTGECSLETTVGDDLTFPQYVLPPSVVYTLDNVNTYNVDGAPFNGEDVLNDTNRQLADGVGTTAHRRARTPEVALVTPDFMSTFRSTDEMANTTLKGQQFGGLSLFLRSGRPCSGLSGKHHLQHSSSLYGTLRRRSLSGVSRNYTPYPQTPFTPDVHGSTQYSFSNIYTRLNSVDYTQQAKITASALQSALDRFVKLDDQNYFQQVVRVCLPTEAEQQLITEEVGSGGKSSCDLILLLMHVRKCEGLQLSDDMQYPIVKVYTKTRVLIRTPIMEDRVEPDWPIEVASFITFIRRDADVSFCICDAGQEDKVEYTANLAAADLGENRGVGLRKLVMHRGATESNDEINETKATIEVCMMAVTTSKHHALQKHLDEEEDACKSSDDFSAIYLQVLGVKGLKHRIEAAVHISVEMDGKTKEVLRTHKIAPKTRSPAWPGQTSFCVAQGDGVISFDLFHRDTFVASYDTSVDTLAFGGTGVQCLPLLRAQGTGGDPYGDLYVSILGTKTPCGEEDVVERPSKLLVVHVEALSLRQNLDLEFVPDPFVIIRGPKGEVIMRTAMNFGTYEAKWSEERASCFILCPSLPGCVVTYHLEVYDNNESSKIGEATMTVTVNGTKRNRMMLDIGGKGLLTVVAHSFPIQDVISHSQPPGSGLTNHLTDTSSSSIEEGYFLQVHICSCESLQGTGFDDFQIDPVVTARVGRKRIVVAPLVSGCTAPQWKYPKATFVLPFVPDVLSHIVLEVWDTNIELCDVLGVARLPMEEICRTGTHKYTLQPHKDQEYGRRRDLGTIVVNTRFGRVNGAVVSKESPLFFSAGSSGSGIFRSRLFPSTNRGPNLPITRVRLHISSCCSAVSAWPFDFIKVTLTCLHHVLLEVRKSCKDEFFVAWSVDDAQTIVDLRAIYGRSLRLAVSGGKEETGRLTTHIGAAHLPFSTLASASPEVVSVRSLPLVDQATEERSSGSRSGRRCVTPSVSAQEPSITVSLLALDSDHSVSLGSE
Protein: Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] (P00967)
Organism: Drosophila melanogaster (Fruit fly)
Function: Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway.
Interaction partners:
- Amidophosphoribosyltransferase
- Serine hydroxymethyltransferase
- Myb-binding protein 1A
- Bifunctional purine biosynthesis protein ATIC
- Phosphoribosylformylglycinamidine synthase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
- Amidophosphoribosyltransferase
- Adenylosuccinate synthetase
- Adenylosuccinate lyase
- C-1-tetrahydrofolate synthase, cytoplasmic
Sequence:
MSHRVLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAKWSKENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIPTARYESFTDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAANAKEACQAVDEILGDLKYGQAGATLVVEELLEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGAYCPCPLISQPALELVQKAVLERAVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNCRFGDPETQVILPLLESDLFDVMEACCSGKLDKIPLQWRNGVSAVGVILASAGYPETSTKGCIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGRVLIAIALDGSLKEAAAKATKLAGSISFSGSGAQYRTDIAQKAFKIASASTPGLSYKDSGVDIDAGDALVQRIKPLSRGTQRPGVIGGLGGFGGLFRLKELTYKEPVIAEATQGVGAKIHLALTHEFYENVGYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLVKGMADGCRDARCALVGGETAEMPSLYAPGQHDMAGYCVGIVEHSRILPRFDLYQPGDLLIGLPSSGLHCAGFNEILTQLAASKVNLRERSPVDGGDDGLTLAHVLATPTQLYVQQLLPHLQKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDFGAVPVPKIFGWLAGKLKLSAQTILERHNCGIGMVLILPQSSQLWRTSLPGAKVLGVLQRRSKVSGSPVQVRNFVEQLEKVASPFGGLGDRELPEELKKLPSNSDLSAPREECFENAAGRRLTRIPTHYKDPILILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLAKGVHSGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLAEIQPGDVLIGLPSSGVHSNGFSLVHAVLKRVGLGLHDKAPFSDKTLGEELLVPTKIYVKALSTLLSRGKHGIKALAHITGGGLSENIPRVLRKDLAVRLDANKFQLPPVFAWLAAAGNISSTELQRTYNCGLGMVLVVAPTEVEDVLKELRYPQRAAVVGEVVARKDPKKSQVVVQNFEASLARTQKMLSQRRKRVAVLISGTGSNLQALIDATRDSAQGIHADVVLVISNKPGVLGLQRATQAGIPSLVISHKDFASREVYDAELTRNLKAARVDLICLAGFMRVLSAPFVREWRGRLVNIHPSLLPKYPGLHVQKQALEAGEKESGCTVHFVDEGVDTGAIIVQAAVPILPDDDEDSLTQRIHKAEHWAFPRALAMLVNGTALISPEVSSQ
Protein: Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (MAIA) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c) (Q96P31)
Organism: Homo sapiens (Human)
Function: Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells. Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling. Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells. Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion. Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species-specific gamete fusion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16849395, ECO:0000269|PubMed:20190142, ECO:0000269|PubMed:36070373}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}. Cell projection, microvillus membrane {ECO:0000269|PubMed:36070373}. Note=Localized along the oolemma microvilli of unfertilized oocytes. {ECO:0000269|PubMed:36070373}.
Interaction partners:
- Tyrosine-protein kinase ZAP-70
- Tyrosine-protein phosphatase non-receptor type 22
- Tyrosine-protein kinase SYK
- Polymeric immunoglobulin receptor
- Tyrosine-protein phosphatase non-receptor type 11
- B-lymphocyte antigen CD20
Sequence:
MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKHDKIQITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNVILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEVTSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRYYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLTAAGITGLVLSILVLAAAAALLHYARARRKPGGLSATGTSSHSPSECQEPSSSRPSRIDPQEPTHSKPLAPMELEPMYSNVNPGDSNPIYSQIWSIQHTKENSANCPMMHQEHEELTVLYSELKKTHPDDSAGEASSRGRAHEEDDEENYENVPRVLLASDH
Protein: Protein turtle homolog A (Dendrite arborization and synapse maturation protein 1) (Immunoglobulin superfamily member 9A) (IgSF9A) (Q05BQ1)
Organism: Mus musculus (Mouse)
Function: Functions in dendrite outgrowth and synapse maturation.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Note=Enriched at the excitatory synapses in mature neurons. {ECO:0000250}.
Interaction partners:
Sequence:
MIWCLRLTVLSLIISQGADGRRKPEVVSVVGRAGESAVLGCDLLPPAGHPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQTGASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQFQETPPLVLEVKELEAVTLRCVARGSPQPYVTWKFRGQDLGKGQGQVQVQNGTLWIRRVERGSAGDYTCQASSSEGSITHATQLLVLGPPVIVVPPSNSTVNSSQDVSLACRAEAYPANLTYSWFQDGVNVFHISRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSNGFLHPPSASAYLTVLYPAQVTVMPPETPLPTGMRGVIRCPVRANPPLLFVTWTKDGQALQLDKFPGWSLGPEGSLIIALGNENALGEYSCTPYNSLGTAGPSPVTQVLLKAPPAFIDQPKEEYFQEVGRELLIPCSARGDPPPIVSWAKVGRGLQGQAQVDSNNSLVLRPLTKEAQGRWECSASNAVARVTTSTNVYVLGTSPHVVTNVSVVPLPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRAHHDWVSLAVPIGATHLLVPGLQAHAQYQFSVLAQNKLGSGPFSEIVLSIPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELIPGRLDGYILEGRQGSQGWEILDQGVAGTEIQLLVPGLIKDVLYEFRLVAFADSYVSDPSNVANISTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAACLMNRRRAARRHRKRLRQDPPLIFSPRGKSGSHSAPGSGSPDSVTKFKLQGSPVPSLRQSLLWGEPARPPSPHPDSPLGRGPLPLEPICRGPDGRFVMGPTVAPSQEKLCLERSEPRTSAKRLAQSFDCSSSSPSGVPQPLCITDISPVGQPLAAVPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPTPAPPPDFMDSQPCPTSSFLPPPDSPPANLRAVLPGTLMGVGVSSEPPYTALADWTLRERVLPGLLSAAPRGSLTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDMELLETWHPGLASSRTHPELEPELGVKTPEESCLLNPTHAAGPEARCAALREEFLAFRRRRDATRARLPAYQQSISYPEQATLL