wanglab/gogpt-training-data huggingface dataset:
Protein: RH22958p (Q8SY89)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGASNRILQVALCASVFSLICFVIAFSTPYWLVTDGRLQNQRFTNLGLWEVCFNNFQDIHRFFDNSFNGCLWVFEEEYYIIHDFLLPGFYISVQLFATLCFVMCLVVIPLTVAFLRTSRDDDRYMVLLLAIGSCQVVGSVFGFIAVVIFGAKGDSRDWMPGWQNNDMGWSFALGVVGAVLLLPSGVLYLVGARRERYKRLNEISNREISEYGDEYYQNQGPSAVLPTAPSPYQSYFASEPSRPRRPQQSSASNSAVQGGIQTDI
Protein: Occludin (Q6PP84)
Organism: Bos taurus (Bovine)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
VMCIAIFACVASTLAWDRGYGTLMGAGVNYPYAGSAFGSYGSGYGYGYGYGYGYGTGYTDPRAAKGFLLAMAAFCFIAALVIFVTSVVRSGISRTRRYYLTVIIVTAVLGIMMFIATIVYIMGVNPTAQASGSLYSSQIYALCNQFYTPAATGLYVDQYLYHYCVVDPQEAIAIVLGFMVIVAFALMIFFAVKTRRKMNCYDKSNILWDKERIYDEQPPNVEEWVKNVSAGTQDMPPPLSDYVERVDSPVAYSSNGKVNEKRLYPESSYKSTPVPEVAQELPLTSPVEDFRQPHYSSSGNLETLSKRAPAKGRAGKSRRAEQDHYETDYTTGGESCDELEDDWIREYPPITSDQQRQLYKRSFDTGLQEYKSLQAELDEVNKELSRLDKELDDYREESEEYMAAADEYNRLKQVKGSADYKSKRNYCKQLKSKLSHIKKMVGDYDRRKT
Protein: Collagen type XI alpha 2 chain (A0A8I5ZM36)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MERCSRCHRLLLLLPLVLGLSAAPGWAGAPSVDVLRALRFPSLPDGVRKSKGVCPADVAYRVARPAQLSAPTRQLFPGGFPKDFSLLTVVRTRSGLQAPLLTLYSAQGVQQLGLELGRPVRFLYEDQRGRPQASAQPIFRGLSLADGKWHHVAVAVKGQSVTLIVDCKKRVTRPLPRSVHPVLDTHGVVIFGAHVLDDEVFEGDVQELLIVPGVQAAYQSCGQKDLECEREQRDGPQTQKPHRAQRSPKKEPARLHKPQNQEPQQQPTESLYYDYEPPYYDVMTTETSPDYQEQTDLQVPPTADSFQAEEYGEGGTEPPAGFYDYTYGYGDDYREETELGPALSAETDHTGAVAHGPRGLKGEKGEPAVLEPGMFVEGPPGPEGPAGLAGPPGIQGNPGPVGDPGERGPPGRAGLPGSDGPPGPPGTSLMLPFRFGSSGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSPGLKGESGDLGPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGEPGVKGDRGFDGLPGLPGEKGQRGDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPHGPKGSLGPQGEPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPRGKPGLPGMPGSDGLPGHPGKEGPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPGSRGEDGPEGPKGRTGPTGDPGPTGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPAGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGESGPMGERGHPGPPGPPGEQGLPGTAGKDGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNEGPAGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPFGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSPGVQGEPGVKGPRGERGEKGESGQAGEAGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPGEAGPRGQDGAKGSQGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGTPGPEGRQGEKGAKGDPGAVGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLIGLIGPTGEQGEKGDRGLPGPQGSPGQKGETGIPGASGPIGPGGPPGLPGPSGPKGAKGATGPAGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRSVDGSKLMQDEEATPTGGAPGSPAGLEEIFGSLDSLREEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCARDAFRVFCNFTAGGETCVTPRDDVTQFSYVDSEGSPVGVVQLTFLRLLSVSAHQDVSYPCSGVSQDGPLKLRGANEDELSPETSPYVKEFRDGCQTQQGRTVLEVRTPVLEQLPVLDASFSDLGAPTRRGGVLLGPVCFMG
Protein: Oleoyl-acyl carrier protein thioesterase 2, chloroplastic (EC 3.1.2.14) (18:0-acyl-carrier protein thioesterase) (18:0-ACP thioesterase) (Acyl-[acyl-carrier-protein] hydrolase) (Q9SV64)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays an essential role in chain termination during de novo fatty acid synthesis. Possesses high thioesterase activity for oleoyl-ACP versus other acyl-ACPs.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Stearoyl-[acyl-carrier-protein] 9-desaturase 7, chloroplastic
- Enoyl-[acyl-carrier-protein] reductase, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 3, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 6, chloroplastic
- Long chain acyl-CoA synthetase 1
- Long chain acyl-CoA synthetase 3
- Long-chain-fatty-acid--[acyl-carrier-protein] ligase AEE15, chloroplastic
- Long chain acyl-CoA synthetase 4
- Stearoyl-[acyl-carrier-protein] 9-desaturase 2, chloroplastic
- Long chain acyl-CoA synthetase 5
Sequence:
MLKLSCNVTDHIHNLFSNSRRIFVPVHRQTRPISCFQLKKEPLRAILSADHGNSSVRVADTVSGTSPADRLRFGRLMEDGFSYKEKFIVRSYEVGINKTATIETIANLLQEVACNHVQNVGFSTDGFATTLTMRKLHLIWVTARMHIEIYKYPAWSDVVEIETWCQSEGRIGTRRDWILKDCATGEVIGRATSKWVMMNQDTRRLQRVTDEVRDEYLVFCPPEPRLAFPEENNSSLKKIPKLEDPAQYSMLGLKPRRADLDMNQHVNNVTYIGWVLESIPQEIIDTHELKVITLDYRRECQQDDIVDSLTTSETPNEVVSKLTGTNGSTTSSKREHNESHFLHILRLSENGQEINRGRTQWRKKSSR
Protein: Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (Q6NLR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MEIFYFVVFGGLAAIVAGLELSKSNKDRINTSSAFNSFKNNYLLVYSLMMAGDWLQGPYVYYLYSTYGFGKGEIGQLFIAGFGSSMLFGTIVGSLADKQGRKRASITYCITYILSCITKHSPQYKVLMVGRVLGGIATSLLFSAFESWLVAEHNKRGFEQQWLSVTFSKAIFLGNGLVAIIAGLFGNYLVDSLSLGPVAPFDAAACFLAIGMAVIISSWSENYGDPSENKDLLTQFKNAASAIASDEKIALLGAIQSLFEGSMYTFVFLWTPALSPNEEDIPHGFIFATFMLASMLGSSIASRLLAHSSPKVESYMQIVFVISSAALMLPVVTSFLVAPSGVKGGSISFSGCIQLMGFCTFEACVGIFWPSIMKMRSQYIPEEARSTIMNFFRIPLNIFVCLVLYNVDAFPMTVMFGMCSVFLFVASILQRRLMNVAEIHKSRSQEWSAEKEMTSEADPLNP
Protein: GTP-binding protein RHB1 (EC 3.6.5.-) (GTP-binding protein RSG1) (P25378)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the regulation of arginine and lysine uptake. Acts through the CAN1 permease.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12456008}; Peripheral membrane protein {ECO:0000269|PubMed:12456008}. Note=Cell periphery, adjacent to the plasma membrane.
Interaction partners:
- Serine/threonine-protein kinase TOR2
- Serine/threonine-protein kinase TOR1
- Target of rapamycin complex 1 subunit KOG1
- Target of rapamycin complex subunit LST8
- Protein BTN2
- ATP-dependent molecular chaperone HSP82
- ATP-dependent molecular chaperone HSC82
- Protein BTN1
- Serine--tRNA ligase, cytoplasmic
- 30 kDa heat shock protein
Sequence:
MEYATMSSSNSTHNFQRKIALIGARNVGKTTLTVRFVESRFVESYYPTIENEFTRIIPYKSHDCTLEILDTAGQDEVSLLNIKSLTGVRGIILCYSIINRASFDLIPILWDKLVDQLGKDNLPVILVGTKADLGRSTKGVKRCVTKAEGEKLASTIGSQDKRNQAAFIECSAELDYNVEETFMLLLKQMERVEGTLGLDAENNNKCSIM
Protein: Protein CASP (P34237)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in intra-Golgi transport.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:12429822}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12429822}.
Interaction partners:
- GRIP domain-containing protein RUD3
- Golgi SNAP receptor complex member 1
- Maintenance of telomere capping protein 1
- GRASP65 homolog protein 1
- Endoplasmic reticulum transmembrane protein 3
- Intracellular protein transport protein USO1
- Conserved oligomeric Golgi complex subunit 4
Sequence:
MDTSVYSHALDIWAKADLTNLQRELDADVIEIKDKETLSLNSRKSLATETKKFKKLEPEEKLNNVNKIIKQYQREIDNLTQRSKFSEKVLFDVYEKLSEAPDPQPLLQSSLEKLGKIDDSKELKEKISYLEDKLAKYADYETLKSRLLDLEQSSAKTLAKRLTAKTQEINSTWEEKGRNWKEREADLLKQLTNVQEQNKALEAKISKNIDIEGNGNEDGDQENNQKEVSTRIAEYNLVTQELETTQARIYQLEKRNEELSGALAKATSEAEKETELHAKELKLNQLESENALLSASYEQERKSTSHAINELKEQLNSVVAESESYKSELETVRRKLNNYSDYNKIKEELSALKKIEFGVNEDDSDNDIRSEDKNDNTFESSLLSANKKLQATLAEYRSKSTAQEEERNELKKSVDQLKQQIATLKEANEKLETDLEKVENVSPHFNETASMMSGVTRQMNNRTSHKMSPTSSIIGIPEDGELSGNQSTILPIVTKQRDRFRSRNMDLEKQLRQGNSEKGKLKLEISKLKGDNTKLYERIRYLQSYNNNNAPVNQSTERIDVESQYSRVYDESLHPMANFRQNELNHYKNKKLSALEKLFSSFAKVILQNKMTRMVFLFYCIGLHGLVFMMSMYVINISGYMTPEVGIVQSAKSSSNLNGGLGGAEKVAAGVGSVHGINR
Protein: Uncharacterized protein orf183 (Q2F992)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGLRFDKSIEQEIEDFFASKNLDTVAQSPYIGLIRAVELLEKEGDGPAPANGNDAGSPGPAGSERLSSSGSSVNQPEPLTQDLLADAVTYESPNYLSDAESTNSLGPVTDLASPLDPFSIHPIMDLLMGNYYLAFTNESLSMAVTVVFLLLRVYFLYIWVRAAFPRYRYDQLMGLSDDPKLKD
Protein: Acetylserotonin O-methyltransferase (EC 2.1.1.4) (N-acetylserotonin O-methyltransferase) (AtASMT) (Q9T003)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methyltransferase which catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Does not seem to possess caffeate O-methyltransferase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26484897}.
Interaction partners:
- GCN5-related N-acetyltransferase 1, chloroplastic
- GCN5-related N-acetyltransferase 2, chloroplastic
- Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 2
- Leucine-rich repeat
- Maf-like protein
- Maf-like protein
- Phenylacetaldehyde synthase
Sequence:
MSSDQLSKFLDRNKMEDNKRKVLDEEAKASLDIWKYVFGFADIAAAKCAIDLKIPEAIENHPSSQPVTLAELSSAVSASPSHLRRIMRFLVHQGIFKEIPTKDGLATGYVNTPLSRRLMITRRDGKSLAPFVLFETTPEMLAPWLRLSSVVSSPVNGSTPPPFDAVHGKDVWSFAQDNPFLSDMINEAMACDARRVVPRVAGACHGLFDGVTTMVDVGGGTGETMGMLVKEFPWIKGFNFDLPHVIEVAEVLDGVENVEGDMFDSIPACDAIFIKWVLHDWGDKDCIKILKNCKEAVPPNIGKVLIVESVIGENKKTMIVDERDEKLEHVRLMLDMVMMAHTSTGKERTLKEWDFVLKEAGFARYEVRDIDDVQSLIIAYRS
Protein: Membrane fusion protein (MFP) family protein (E0SC32)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004377, ECO:0000256|RuleBase:RU365093}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004377, ECO:0000256|RuleBase:RU365093}.
Interaction partners:
- Alkaline protease secretion ATP-binding protein aprD
- Outer membrane exporter of proteases
- Toxin secretion ATP-binding protein
- serralysin
- serralysin
- serralysin
- serralysin
- Alkaline proteinase inhibitor
Sequence:
MTGMDITTQDELNEAAMRDRASRDEERALRLGWWLVLAGFGGFLLWALLAPLDKGVAVQGNVVVSGNRKVIQHMQGGIVDRIQVKDGDRVAAGQVLLTLNAVDARTTSEGLGSQYDQLIAREARLLAEQRNQSSLAATPRLAQARQRPEMAAIIALQEDLLRSRQQSLKLEIDGVRASIDGLETSLGALQKVMSSKQSEQATLSQQLQGLRPLAADNYVPRNKMLETERLFAQVSGELAQTSGEVGRTRRDIQQQKLRIAQRQQEYDKEVNSELSDVQAKLNEVISQREKADFNLANVQVRAPVAGTVVDMKIFTEGGVIAPGQVMMDIVPEDQPLLVDGRIPVEMVDKVWSGLPVELQFTAFSQSTTPRVPGTVTLLSADRLVDEKDGTPYYGLRIQVSEEGKRSLHGLEIKPGMPVQGFVRTGERSFINYLFKPLMDRMHLALTEE
Protein: Tau-cadinol synthase (LaCADS) (EC 4.2.3.173) ((+)-gamma-cadinene synthase) (Gamma-cadinene synthase) (EC 4.2.3.92) (U3LW50)
Organism: Lavandula angustifolia (Lavender)
Function: Sesquiterpene synthase that catalyzes the formation of sesquiterpenes and sesquiterpenoid alcohols. Converts farnesyl diphosphate (FPP) to tau-cadinol. Converts FPP to gamma-cadinene. Tau-cadinol is the major product.
Interaction partners:
Sequence:
MATSAVVNCLGGVRPHTIRYEPNMWTHTFSNFSIDEQVQGEYAEEIEALKQEVRSMLTAATTCKEQLILIDTLERLGLSYHFETEIEQKLKEIILHINREEDASGGDCDLYTTSLGFRVIRQHQYHISCGVFEKYLDKDGKFEESLSSDTEGILSLYEAAHVRFRDETLLQEAARFSRHHLKGMEEVLESPLREKVQRALQHPLHRDIPIFYAHFFISNIYQKDDSRNELLLKLAKSNFMFLQNLYKEELSQLSRWWNKFDLKSKLPYARDRLVEAYIWGVGYHYEPRYAYVRRGLVIGIQIIAIMDDTYDNYATVDEAQLFTEMFERWSMDGIDGVPDYLKIAYHFVVSAFEDYERDAGKLGKQFAAPYFKQTIQQLARAYNQELKWVMGTQSMPSFQDYAKNSEITSCIYIMSASVFHGLESVTQETIDWLKNEPNFAVSTGMIGRYWDDIGSHERESRGGKMLTAVGCYMKQYGVSKKEAVRKFREQVEDLWKDVNKGYTAMTCMPRETAVLFLNYARMCDASYTENNDDGYTDPDFSKRKISALFLDPLVF
Protein: Small ribosomal subunit protein mS31 (28S ribosomal protein S31, mitochondrial) (MRP-S31) (S31mt) (Imogen 38) (Q61733)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P82925}.
Interaction partners:
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein mS33
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein mS39
- Small ribosomal subunit protein mS34
- Small ribosomal subunit protein mS23
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS7m
Sequence:
MLHRIPAFLRPRPFSGLPLSCGNRDVSVAVLPAAQSGAVRTENNIQRHFCTSRSICSKKVDQSVPANEISQKAAESQGRGKETLKKDLLDIIKDMKVDLSTANVKTPKPRGRKPSASLEATVDRLQKAPEDPPKKRNEFLSPELVAAASAVADSLPFDKQTTKSELLRQLQQHEEELRAQKDREKRRISFTHIISNMKIAKSPSGRASTRPQHQIQFDEDMDSSLKQEKPTDFRKRKYLFKGKRLSIFADKAFADEPPEPEASPSLWEIEFAKQLASVADQPFENGFEEMIQWTKEGKLWEFPVNNEAGLDDDGSEFHEHIFLDKYLEDFPKQGPIRLFMELVTCGLSKNPYLSVKQKVEHIEWFRNYFNEKRDILKENNIAFT
Protein: ROBO1 protein (Q2M1J3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Protein: Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog) (Q9Z0E3)
Organism: Mus musculus (Mouse)
Function: Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (Probable). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (By similarity). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00185, ECO:0000255|PROSITE-ProRule:PRU00747, ECO:0000269|PubMed:11156688, ECO:0000269|PubMed:19015306, ECO:0000269|PubMed:26070482}. Cytoplasm {ECO:0000269|PubMed:11156688}. Note=Predominantly nuclear but also cytoplasmic. Found in nuclear body-like structures (dots) and in a filamentous vimentin-like pattern. {ECO:0000250|UniProtKB:O43918, ECO:0000269|PubMed:19015306}.
Interaction partners:
- Histone H3.3
- Forkhead box protein N1
- Histone H3.1
- Histone H3.2
Sequence:
MAGGDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLKEKEGCPQAFHALLSWLLTRDSGAILDFWRILFKDYNLERYSRLHSILDGFPKDVDLNQSRKGRKPLAGPKAAVLPPRPPTKRKALEEPRATPPATLASKSVSSPGSHLKTKPPKKPDGNLESQHLPLGNGIQTMAASVQRAVTVASGDVPGTRGAVEGILIQQVFESGRSKKCIQVGGEFYTPNKFEDPSGNLKNKARSGSSLKPVVRAKGAQVTIPGRDEQKVGQQCGVPPLPSLPSEPQVNQKNEDECAVCHDGGELICCDGCPRAFHLACLSPPLQEIPSGLWRCSCCLQGRVQQNLSQPEVSRPPELPAETPILVGLRSASEKTRGPSRELKASSDAAVTYVNLLAPHPAAPLLEPSALCPLLSAGNEGRPGPAPSARCSVCGDGTEVLRCAHCAAAFHWRCHFPTAAARPGTNLRCKSCSADSTPTPGTPGEAVPTSGPRPAPGLAKVGDDSASHDPVLHRDDLESLLNEHSFDGILQWAIQSMSRPLAETPPFSS
Protein: Enhancer of filamentation 1 (CRK-associated substrate-related protein) (CAS-L) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (p105) (A0A8I3PDQ1)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Negatively regulates embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKl and SHPTP2 to the tyrosine phosphorylated form (By similarity). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (By similarity). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts. Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity). In conjunction with NKX2-5, positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity).
Subcellular location: Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q14511}. Nucleus {ECO:0000250|UniProtKB:Q14511}. Golgi apparatus {ECO:0000250|UniProtKB:Q14511}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q14511}. Cytoplasm {ECO:0000250|UniProtKB:Q14511}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q14511}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q14511}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:27926875}. Cell projection, cilium {ECO:0000250|UniProtKB:Q14511}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q14511}. Basolateral cell membrane {ECO:0000269|PubMed:27926875}.
Interaction partners:
Sequence:
MWARNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPIQETPSGQDQPTSGLMHQTFGQQKLYQVPNPHSAPRDTIYQVPPSYQHQGIYQVPTSHGIQEQDVYQVPPSVQRSIGAANGPHLSKKVVTPVRTGQGYVYEYPSRHQKDIYDIPPSHTTQGVYDIPPSSVKVPVFSLPVGEIKPQGVYDIPPTKGLYAIPPSACRDEAGLREKEYDFPPPMRQAGRLDVRPEGVYDIPPTSTKPTGKDLHIKYNCDAPGAAELATRRHQSVLLNHAPSQLGQSPGAQNDAYDVPRGVQFLEPPAETSEKANPEERDGVYDVPLHNPPDAKGSQDVVDGMNRLSFSSTGSTRSNMSTSSTTSKESSVSASPSQDKRLLLDPDTAIERLHRLQQTLEVGVSSLMALVTTDWRCYGYMDRHINEIRTSVDKVELFVRDYLHFARGAVANASCLPELTLHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAVNKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALFRPGPGSSHVKSGSENIMNSTEYPHAASQMPLLHPGDHKAQGLNKPLPPSLGKDQPPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIIKQNKLQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSSVGAQDRQLLCFYYDQCETHYISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQDICHKVMNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
Protein: RNA polymerase II degradation factor-like protein (DUF1296) (F4I1G1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- ATP synthase subunit b, chloroplastic
- ATP synthase subunit d, mitochondrial
- Pyridoxal 5'-phosphate synthase PDX1-like 4
- ATP synthase subunit O, mitochondrial
- ATPase, F1 complex, OSCP/delta subunit protein
- ATP synthase subunit delta, chloroplastic
- ATP synthase subunit 9
- ATP synthase subunit 9, mitochondrial
- ATP synthase subunit a-1
- Pentatricopeptide repeat-containing protein At4g17616
Sequence:
MSSSKVGGGARKGIQDIPSGSRKIVQSLTEIVNSPEAEIYAMLKECNMDPNETVSRLLSQDPFHEVKSKKEKKKETRDISDSRPRGANNTYNRGARGGSARYAGRSGSTHFSSTDSGNFQGKSTNKKESGTQGYTSSWSSASGVANTYQTPHSEPIAMENKLPPVTLGDGISSSKSASGHQTAWFGAPGQRSMAEVVKMGRPQNKTTKQNVNVGSEINHEHEVNANQQAPVKDEWPSIEKPLAPSTSSLSVAPAESEVRNGLADFQSDRGDQYLKDRLENIHIAESGPSESRGVDHVQADSVQEDESVVSSEIDDNPYQTQSHPVEHHKDEDDVSSGSASFQQLDSHDQEVSHEEDRPAVVIPNHLLIHTEECAQLSFGSFGGFGSRPLSNSVEATSDVAPQIEHSDARNTEFYGDEHLGSTTNGNMVHTPATGNYDDSLETRREVLKQENSEGAQEHQYTFTQSEQGYAYENAKQQQMNSAYDASHTNSQNQMHNLDSLSNVMQGYSHSVPNTLLAQTAQNARELDFQYSPFSAQQSMQSRTSNNASSLGGQSISMPEALRGSGIPATQPTQQTLPGANIATGPALPQQLPMHYSQPTLPLTHYANMIGYPLMPQNYPYMPSAFQQTFAGNSAYHQQLAALLPQYKTNVSPGNLPQSATAPASAYGFGNSTNVGSAGNFPLNQQSATTGTTLGYEDVLSSQYKENHLLALQQQQQQQQHQQQNENSAMWHQGHGSRTMSGVPTNTYYNLQAQQQLQLQHQQQQQQAQQAAGGYRQAQQQQHYGSHGYPNYYQSQTEMSLERQQQNPRDGAGSQAGQPSNQSQQQLWQNSY
Protein: N-alpha-acetyltransferase 35, NatC auxiliary subunit (N-terminal acetyltransferase C complex subunit mak10) (NatC complex subunit mak10) (Q9USY3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the NatC N-terminal acetyltransferase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- N-alpha-acetyltransferase 30
- N-alpha-acetyltransferase 38, NatC auxiliary subunit
- N-terminal acetyltransferase A complex catalytic subunit ard1
- N-terminal acetyltransferase B complex subunit arm1
- N-terminal acetyltransferase A complex subunit nat1
- N-terminal acetyltransferase B complex catalytic subunit naa20
- Uncharacterized N-acetyltransferase C1271.07c
- Small nuclear ribonucleoprotein E
- Uncharacterized N-acetyltransferase C663.13c
- N-terminal acetyltransferase A complex subunit-like protein C418.02
Sequence:
MSVKESLSLLNSMQGNVKIGNVEPAKGNEGYVDNAGYVDCTKSYFEATKSLKEEQLVCDPKFTLLDSISAFEIMEPKMDSGIDYQPLRVDFSRDLSYLEILALMDLIVSAEKEWHYGSPLSESLLCSAHVFSICKSPISQVGDSGFSSGSGRNTTDIVLFPFVLAVIKCCDIVHREFLMGNLYDEEDISSFSYHMSFLQNYPIEKLNYLLQSSIEYLASEVIKFSAELRQIIEGILNRIQLRIGILRVYERSDIKTTIDALHLIKNLVPEIQNTVSVVDSSIKESILKQYWDFRVQAQLVATAPVRNIPPTGIEHSYQRILYFADDMLLILNSHTLASSLAVYQFCLDFTRLNRTPEPYVRSSLQALITANNAVNLRDQPTSYMLECIREFSGLPSNFYNPNTRTVIEKNSISSAYGPLVESLIAHSTNIMVDLVRICSHNPCRFRRNLINLLPEITVAHFEAEALDLKFVAKSLPSNGPFSSFIYHVKLNAIEHILLSSFEQKLHQPYQWPHFFAVLDHVFSIHQTHLELHGKDRNTPPMAKTFVTYLHRILNAIKETYSGYLLLTVLCMRLNIIKTPSFTLDEKIQESYYMAHYRPLINLRQPKPLLRSEADCIIKNLQNFSTDDLIIKSNEKFTAAKNSLINVIKSGFEQNEFINPYFLQTNYLKNLLCCCITNLVSLAILSKDHSANLKIVEIPGNPLPSLSRT