Protein: Cyclic GMP-binding protein C (EC 2.7.11.1) (Ras guanine nucleotide exchange factor T) (RasGEF domain-containing protein T) (Q8MVR1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase.
Interaction partners:
- Latrophilin receptor-like protein A
- Ras-like protein rasD
- Ras-like protein rasC
Sequence:
MSQKQKPIRFQDYQFTATKDEAYGRSDRYVKQFLNKNLLKKKDGTLGTAEELLTLIQQSNINVVTASTGGAAMGAMLNHTVSTINLTGSGSVPTYNPSDNRNSGSHVITSTNSVISNSSISSTGVINNNINNNSNINSNTGTTTTTISLPNNTEIKTALVSTGSQNASDTAQIDIEFHLSYTQLVTLPPSIFSLIWIQKLVLTHHNIKTLSEDIGKLQQLQVLVLENNRLINLPQSIGDLVNLKRLEVDNNHLVSLCSLERLSKLEVLSVNNNKLTLLPTSIASLSSLKTLNIKSNPIITPPSTVVSKGLKDIVSFLRELETGARPCLRSKLVVLGDPGVGKTSVVQCMKGKKKKTNVTSSSINIGGSSGSEVGIEIDQYDFDVVFDEDDKKRRVITLSTWDIANQDVYFASSQLFDSERSVYIVVFNLNNDDFSAIEYWLHCIMSTSPNSPIVLVGTHIDAFENLNVVNAVLESVASRFQKRFTNIQAIISVSCTTGYDVDKLRQLIEDIIKTQPYLKEKVPSSFFTLEEALIEVKKKRIPPVMMWQEYINLANICNLKDSVQIQRATEFLHNIGSIVYFNDLNSSTVGKMVILDQQWIINCMSSLITSKLLINNCNGIVRQSDLELVWKAPTYPEHLHPALLSIMQAFEICRSLSPSDLVRPEEVNEKEVMGDRNLVPNLLSDNTNIVAQWDDFIDPDTILLNRQYHLPFLPEKFFGKLIIHLMNFTKVESCQKRAVILRNQDNHEALIELKTIKDNKDGTFKKILTVDVRGLVSPVSLLRIVTDTIESLFSQWYKLDIKRYISCYECAILYDRNPTLFTIEECELAVIDGKTVLTCNQKSDSDRVSTSHRLKLDILAPDISMVDIPIPRFNLSEVKINKEVGRGAFGIVYEAEWMSEWIALKKLLLPSSTDTTNLNGNGEVMVYDDPDQLIEDRLRVFREFRHEVYYMSGLNHPNVMKISGFCIQPLCMALEYVRYGSLYSLLSNSSIEISWGLRLQIASEIAKGMQHLHSHNPPVIHRDLKSPNILLNGITEGQNSVATIIDFGTSTALYGGAALIRCVDQPLWLGPEVLAGTAYSEPSDVYSFGIILWELYTRAHPFDEFQFGQWMSKLEDEIIRGLRPTIPPTCPPEYVELIQSCWTHEPNSRPTFTSIVEILGQIKKKFAPLPFTHPPHIRNMMRKSRSSSISEAMLPSNLLHLNLNGINNNNNNSNNNNNSIPVTTISLTSSGTSPTNSPVGGLLSQSLTQPITSGGSTSGILSTSVNRDNSSLVSASSLGNNTSTSSLASLVSNNSGLHHSPSASDGLNDYYGADNNNNNNDSTMDFFQDIFTEEENEQPYPFADDDQQKGILFGFDEEQTNPSASSVSIIIAATMAKMIEMMTKGESSATLKSEHISTRRRSDTAGKNGVPPHWRNSVPLSTNSSTTLDETFIDDFIYVYRSFTTPRNIFKLLVRRFFGPRHTDKVDTFTIKKFEQKKAAIRQGIAVFLRKWVADITELEFRQEEFWLYHNTVAFTKQFIASEFPTIATQIYGTLTTHEDEVNLTNQRFLQIAFSESEIQIDRAMSSMQLTTPKPFRSQKNLANSYNSQSGGGDSSFYYQPSSNDVSRVFLNLATGMRDPLLGITVKEKKFKKDKVSTLCCSGSEIIDWITKCMPIKREEASILVLDMLMKQFFIQISDDGIPISNQKGTNPTFSDSPTSFYMFLEDDPELIARQYTFLELKYLQNIHPRELLGFSVGLVMPNENEKDPEKWRQSNFPHIYDYFRWFNKMTMLVSTEILRQRDIKQRASIIEKYISIALEYLSLWNFNGIMQVLSSLHSEPISRLSATWAKVSQRSMDCFYELSRLMLPESNYLPLRTALASQKPNTIIQASPLYPNISAYMVHTVCPTIPFLGALIADLSQTCTENPTFISSGGEKMINILRVKRLSKKMKMFKEYKEMPTQYLPALTTIPLQYYEHYVNDLKALDSLQIDRLSDIERKLEIICEKNGTTNDDKEKGDENGGGLTSSNFFGNGSDELTERDWTILLTNASVIAYNRGDVVMEENAINTHLYRIKSGAISVEKKDKEGINCKVATMFAPKMFGEMSFLGNKTTARLTVDEESDLYVMDIPFLNNLFNGHPRLGAKFYKIMANQLAIRLKNLPWSKPKNTTGGSSSSNQSAGPDNILGTTPTGISSSGGGLTSLLNQNLSSIMSLSNSNTPPASPRVMTTPTLPSPPAPLQSPPTSGISSPTTTTSTTTDQQKINNTIFQNVHPTINVHRTSSSANLVSPHGRPSNSGFGHSSGGERTINKDPHQRDSGSMDKPILSLGSGGTPRGDGARSGSISYLGRTQTSTSPLNEGLSGGQQPVMKKNDQEFCQRFALVDEIVIKDYPCSLNRSGRLYISQQHVCFYSKFFGYKTKKVIPFKNIDKLICINVNQIELTRLKNTVPSNYRLTFQTGKDREDAFSMIHILWDSSKVSNSSSDEIKNKLAAERKKVNNLTLKTRSNKNKGDELTKEDWELIGCEGSRSSTFKKDEVIIREGERMQKIFQIGKGVCRIEKSVPVAPGSSEMKKVVLGTMKQDDTFGEITYLLNGETTADVIADTDQTEVYTIEGQFVNILFDLNPALASKWFKYLATALNKTLIERESQLYA