wanglab/gogpt-training-data huggingface dataset:
Protein: peptidylprolyl isomerase (EC 5.2.1.8) (F4IX26)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MFRLLLLPYAVGAQQKLLQTPRETKVADAWNIKCQNLLLSKANQQKVFIFNHSMASSSSMQMVHTSRSIAQIGFGVKSQLVSANRTTQSVCFGARSSGIALSSRLHYASPIKQFSGVYATTKHQRTACVKSMAAEEEEVIEPQAKVTNKVYFDVEIGGEVAGRIVMGLFGEVVPKTVENFRALCTGEKKYGYKGSSFHRIIKDFMIQGGDFTEGNGTGGISIYGAKFEDENFTLKHTGPGILSMANAGPNTNGSQFFICTVKTSWLDNKHVVFGQVIEGMKLVRTLESQETRAFDVPKKGCRIYACGELPLDA
Protein: Probable N-acetyltransferase HLS1 (EC 2.3.1.-) (Protein CONSTITUTIVE PHOTOMORPHOGENIC 3) (Protein HOOKLESS 1) (Protein UNUSUAL SUGAR RESPONSE 2) (Q42381)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ethylene-responsive N-acetyltransferase required for differential cell elongation in the hypocotyl. Regulates apical hook formation of dark-grown seedlings. May control differential cell growth by regulating auxin activity. May be involved in negative feedback regulation of auxin homeostasis through the control of GH3-like genes. Modulates de novo shoot organogenesis.
Interaction partners:
- Protein transport protein SEC31 homolog B
- Protein DETOXIFICATION 23
- Probable glutamate carboxypeptidase AMP1
- Protein transport protein SEC31 homolog A
- Small polypeptide DEVIL 19
- Probable BOI-related E3 ubiquitin-protein ligase 3
- Transmembrane emp24 domain-containing protein p24delta5
- Coatomer subunit delta
- Protein PIN-LIKES 4
- Selenium-binding protein 1
Sequence:
MTVVREYDPTRDLVGVEDVERRCEVGPSGKLSLFTDLLGDPICRIRHSPSYLMLVAEMGTEKKEIVGMIRGCIKTVTCGQKLDLNHKSQNDVVKPLYTKLAYVLGLRVSPFHRRQGIGFKLVKMMEEWFRQNGAEYSYIATENDNQASVNLFTGKCGYSEFRTPSILVNPVYAHRVNVSRRVTVIKLEPVDAETLYRIRFSTTEFFPRDIDSVLNNKLSLGTFVAVPRGSCYGSGSGSWPGSAKFLEYPPESWAVLSVWNCKDSFLLEVRGASRLRRVVAKTTRVVDKTLPFLKLPSIPSVFEPFGLHFMYGIGGEGPRAVKMVKSLCAHAHNLAKAGGCGVVAAEVAGEDPLRRGIPHWKVLSCDEDLWCIKRLGDDYSDGVVGDWTKSPPGVSIFVDPREF
Protein: Avidin (E7F650)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSSLIWHLVFWTLVISKAASANESSTPNAKVSSCNVTGVWRNELGSTLRVKAEGSEVRGVYQTAVESTHGAAGHHRSARIIGMVSDGTQPTVSFSVLWEKGSCSAWVGQCFILDDGAQVLKTFWMLRSVADNLASAWGSTRMGEDIFFKTGVSN
Protein: G-protein-signaling modulator 2 (Pins homolog) (Q8VDU0)
Organism: Mus musculus (Mouse)
Function: Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P81274}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26766442}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P81274}. Lateral cell membrane {ECO:0000269|PubMed:26766442}. Note=Localizes in the cytoplasm during interphase and at cell cortex during metaphase. Colocalizes with NUMA1 to mitotic spindle poles. Localized at the central and lateral cell cortex regions in a RanGTP-dependent manner (By similarity). In horizontally retinal progenitor dividing cells, localized to the lateral cortical region (PubMed:26766442). In vertically retinal progenitor dividing cells, localized at the polar cortical region (PubMed:26766442). {ECO:0000250|UniProtKB:P81274, ECO:0000269|PubMed:26766442}.
Interaction partners:
- Nuclear mitotic apparatus protein 1
- Protein inscuteable homolog
- Whirlin
- Guanine nucleotide-binding protein G
- FERM and PDZ domain-containing protein 1
- Guanine nucleotide-binding protein G
- Disks large homolog 3
- Guanine nucleotide-binding protein G
- Epidermal growth factor receptor kinase substrate 8
- Guanine nucleotide-binding protein G
Sequence:
MEGNLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDTGEFPEDVRNALQAAVDLYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELKDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSMMSENIEIDGSLHGAGAKLGRRHSMENLELMKLTPEKVPNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKSGSACTKVLQDASNSVDHRAPRSQKKISSDTIGDEGFFDLLRRFQSNRMDDQRCHLQGNCRTTSTAAASATPKLMKAPSVSVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTKGNSPSVLERLMTNDKKEPDEDFFDILVKCQGSRLDDQRCAPPSAATKGPTVPDEDFFSLILRSQAKRMDEQRVLLQRDPNRDSEFGLKELLQNNALLEFKHSGK
Protein: COP9 signalosome complex subunit 6 (Signalosome subunit 6) (Q95PZ0)
Organism: Caenorhabditis elegans
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12781129}. Nucleus {ECO:0000269|PubMed:12781129}.
Interaction partners:
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 1
- Ubiquitin-like protein NEDD8
- COP9 signalosome complex subunit 3
- Cullin-4
- COP9/Signalosome and eIF3 complex-shared subunit 1
- Uncharacterized protein
- Cullin-2
Sequence:
MALNAPSGSCSSKVLLHPLVIMQMSEHYSRTKVQQGPTVKKVFGAILGRQNGRQVEAINSFVLKMETEEMAEPVTFSTEHLLQRADQYLEVFPELQVIGLYCAGEDDNLTPEEKPLLSKLTNAVRNSEKAGQIDATLFLKLNSITAGTTRKLPLFAFEADVTDQEKHKPIEWILVSEESERVGVNHIAKLSTKHGKDGKSVGKKHAEAQDAAMSMLQNRVDLIVAYLEKVQDGTLQPNFEILKEANLLAQKLKTIDRYAAEFTDSFEKEEKTMTVFSLMPRLTTLLGNMQNVWNKLSAQRADLLADDGFHGKSTSRWAHPVRFKSQHLGRPQQADDDDYFDDEDLENDMSGPRRKIHAADSPAGSRRRRVPPRAMNFLGRNSGMQAATDEMELSGQEENMGSNYIPDVPRPSATAHNESDESSQAS
Protein: Small ribosomal subunit protein uS9 (40S ribosomal protein S16) (P62250)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62249}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62249}.
Interaction partners:
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein eS19
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-like protein FUBI
Sequence:
MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR
Protein: Lipase A, lysosomal acid type (Q5T073)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSV
Protein: Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) (Q5U4C9)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro) (By similarity). Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20167603}. Nucleus {ECO:0000250|UniProtKB:Q92630}. Note=Translocates into the nucleus following DNA damage. {ECO:0000250|UniProtKB:Q92630}.
Interaction partners:
- Cellular tumor antigen p53
- Serine-protein kinase ATM
- DDB1- and CUL4-associated factor 1
- DNA damage-binding protein 1
- E3 ubiquitin-protein ligase UBR5
- DDB1- and CUL4-associated factor 7
Sequence:
MLTRKPSAAAPAAYPTGRGGDTAVRQLQASPGIGAGAPRSGVGTGPPSPIALPPLRASNATTTAHTIGGSKHTMNDHLHLNSHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPGVPERQLESIHRRQGSSTSLKSMEGMGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTAVKRVTESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS
Protein: High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (P17095)
Organism: Mus musculus (Mouse)
Function: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Transcription factor Jun
- High mobility group protein HMGI-C
- Cellular tumor antigen p53
- Cyclic AMP-dependent transcription factor ATF-2
- Interferon regulatory factor 1
Sequence:
MSESGSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAAKTRKVTTAPGRKPRGRPKKLEKEEEEGISQESSEEEQ
Protein: Probable protein phosphatase 2C 24 (AtPP2C24) (EC 3.1.3.16) (Q9ZW21)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Abscisic acid receptor PYR1
- Abscisic acid receptor PYL9
- Serine/threonine-protein kinase SRK2D
- Serine/threonine-protein kinase SRK2I
- Serine/threonine-protein kinase SRK2E
- Serine/threonine-protein kinase SRK2H
- Serine/threonine-protein kinase SRK2J
- Serine/threonine-protein kinase SRK2B
- Serine/threonine-protein kinase SRK2F
- Serine/threonine-protein kinase SRK2C
Sequence:
MAEICYEVVTDACPSSVYESTPAHSRRRPRFQTVMHEDWEKNCKRSKQEALATRYSSIPRSSREDFSDQNVDVSSPRYGVSSVCGRRREMEDAVAIHPSFSSPKNSEFPQHYFGVYDGHGCSHVAARCRERLHKLVQEELSSDMEDEEEWKTTMERSFTRMDKEVVSWGDSVVTANCKCDLQTPACDSVGSTAVVSVITPDKIVVANCGDSRAVLCRNGKPVPLSTDHKPDRPDELDRIEGAGGRVIYWDCPRVLGVLAMSRAIGDNYLKPYVSCEPEVTITDRRDDDCLILASDGLWDVVSNETACSVARMCLRGGGRRQDNEDPAISDKACTEASVLLTKLALARNSSDNVSVVVIDLRR
Protein: Rfx, isoform F (A0A0B4KFL4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHSRYGFDCQTRHYQQHQQTHHQHHHHHHPNPPCSIPLESPPTPPVISPSAAAAVAYSNLLEKCRCKQSVAANPVPAPPAQLQLQLHHHHHHHHHQTFVASASATSYSNCSALGLGSRTGSGSGSGSGTGSTPSTSSLANSSCAAATNISGGSSNATMYHHHHRRHNNLSYCGVSGQEQNYQVQYVDSELYHSNSSQTQMTYPFCPVGDYQGNGQTAYYSTTGQYGTTSSAGGSSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSPHSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDSDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICERMKKDMDFEFECQFAYITSDTEHQTTPSSASSGGDVGNEAKRLKQE
Protein: Zinc finger protein Paris (Parkin-interacting substrate) (Q9VR05)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription repressor that inhibits transcription of srl/PGC-1-alpha to negatively regulate mitochondrial biogenesis and thereby promotes neurodegeneration. In neurons, functions downstream of the Pink1-park pathway and is likely to act as part of the Pink1-park homeostatic mechanism that maintains mitochondrial quality and function through degradation (mitophagy) and synthesis (biogenesis).
Interaction partners:
- RE40275p
Sequence:
MAEICRVCMDISGKLVNIFDARRRTRVSIAEMIAQCTGFEVKRGDLFSEMICPQCYEDVKSAYGIRQTCEESHQFYCRVRDEGIEDALCALLEEEDWEISEDEDARIDSASAADDDGKSDSKKVAFECRECHKKYQRKGTFLRHMRTHMDGQSFPCPYCKRNFRLRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERPFKCSQCSKTFIKSSDLRRHIRTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGERPFKCSHCPKAFAMKQHLKQHSRLHLPDRPFRCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLARHILEIHK
Protein: Sphingosine kinase 1 (cDNA FLJ78254) (Q53ZR5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
Protein: Protein SenC (Q52720)
Organism: Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Function: Involved in both aerobic respiration and photosynthesis gene expression.
Interaction partners:
- propionyl-CoA carboxylase
- histidine kinase
- Copper-transporting P-type ATPase-2
- cytochrome-c oxidase
- Trans-acting regulatory protein HvrA
- Cbb3-type cytochrome c oxidase subunit CcoP
- Cytochrome c oxidase, Cbb3-type, accessory protein CcoG
- Cytochrome c oxidase, Cbb3-type, subunit II
- Photosynthetic apparatus regulatory protein RegA
- Cytochrome c oxidase, Cbb3-type, maturation protein CcoS
Sequence:
MNVSSKTAALAATAAVVVVVGISAAVTLVPHETDRFAACRKGTGSASAQIGGPFTLISETGATVTDRDVITKPSLVYFGYSYCPDVCPIDSTRNAAAVDLLAERGHDVTPVFISVDAARDTPPVLTEFTDLMSPKMIGLTGTPEQIDAAVKAYRAYYLIRNPGDPATLVDHSTQTYLMDPKLGFLDFYDRDATPEMVADSVGCFLDALQTPGDTPAAGNGN
Protein: Serpin domain-containing protein (Q3U1B7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAGVSPAVFGIPDVTLERNTVAVHEVQENITSGDSLTVASSNTDFAFSLYRKLVLKNPDENVVFSPFSISAALALLSLGAKGNTLKEILEGLKFNLTGAPEPDIHQGFRYLLDLLSQPGDQVQISTGSALFIEKHLQILAEFKEKARALYQAEAFTADFLQPRQATKLINDYVSNQTQGKIKELISDLDKSTLMVLVNYIYFKGKWKMPFDPHDTFNSVFYLDEKRSVNVSMMKIEELTTPYFRDDELSCTVVELKYTGNASAMFILPDQGRMQQVEASLQPETLRKWKNSLKPRRIDELHLPKFSISTDNSLEHILPELGIREVFSMQADLSAITGTKDLRVSKVVHKAVLDVAETGTEAAAATGVKLILLCRKIYSMTIYFNRPFLMIISDTKAHIALFMAKVTNPK
Protein: Ensconsin, isoform B (Q9VZI0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASLGGQHGNISTNPEVENTAKRPESREGSAERKASKDREEKLKYARDRQNEERHRKIEELRAQAEAAQRYREQKEEERRRRIEEIRTRDTEKRHQVEERKKAIFEAEKERREYILKKNQERESRIEVKKRDRNSIGFAFGSSTPRLLDVPADYGLVSPSAFWGQRRSTSISNVAGASLTRRSSERELADSGAKKRASSSTDRQDGSRSGNATPGGHFNNSRPGSAMSTSTNMSTSGLVPRRPATAPRKPRPASIAGTGMSLEEINKLKRDQKPPVKTTAASPSAQTTPKRTANLMSTSLIVTSSSSRLSSAEKKTPSKREPPVPKAASASKALPSRTASSERISRLTKEPKTKDTSAMTRSMIVTSSSTSTITKPAPAPVAPTSAPVPEQNGVAKEVEKTTADEPVPEAEVPTEAPVVVPSVSKAEKEALNTEKTEEGARQEEEQILAVESVPEALVTSINVEEKSDEGNEKEVPKPQEQAAPKKPSRSKENSEVRELTPPEGADLMTASMMAKKITTEEEAKAALAERRRLAREEAERQAELERQRLEAERLAEIKAQEEEAERQRLFEEESTRLAEEQRRGEEERLRKAIEEAQQREEEEKRRREEEEKQRVEREEAEKKAKEEAEKQRVEVAERLKREEKEREERRKRVEAIMLRTRKGGAATTPSKDANDKAAPAATAPENNSSSNSSVTGSSNNSAEGSPSAADSTPAPTATETVQEAPNSQAMYEQSVLDKENSLINSFSTMIIDENAKNLQQVSNGKLLVDFESTNTVPAVANGNGHIENVNNKNDINLLQDVVAPVATQLIDLSIESQDLHLNNNNSLLTSTAATTTLVTADSHENKDISLL
Protein: Yellow-emperor, isoform C (A0A0B4LHN5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MALRLTTIALLHRAPLLVVPKLKATPPTRTLLLRKNLVPFLDDDPCVFSKKAVMHHWGVLPILFITLVGGILKVGAMIRLALVKDDVFFTKDSAYYMYLETRKGPWYKQKSRKWGGRDEYDMPPGLLLANQGDVSGPSFENADKHTSDEGPDFKIIAGHAVITGVALGLATML
Protein: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) (O52631)
Organism: Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W)
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Enolase
- Fructose-bisphosphate aldolase
- Glucose-6-phosphate isomerase
- NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
- Probable transaldolase
- Transketolase
- Fision threonyl-tRNA synthetase
- ATP-dependent 6-phosphofructokinase
Sequence:
MAKIAINGFGRIGRLALRRILEVPGLEVVAINDLTDAKMLAHLFKYDSSQGRFNGEIEVKEGAFVVNGKEVKVFAEADPEKLPWGDLGIDVVLECTGFFTKKEKAEAHVRAGAKKVVISAPAGNDLKTIVFNVNNEDLDGTETVISGASCTTNCLAPMAKVLNDKFGIEKGFMTTIHAFTNDQNTLDGPHRKGDLRRARAAAVSIIPNSTGAAKAISQVIPDLAGKLDGNAQRVPVPTGSITELVSVLKKKVTVEEINAAMKEAADESFGYTEDPIVSADVVGINYGSLFDATLTKIVDVNGSQLVKTAAWYDNEMSYTSQLVRTLAYFAKIAK
Protein: Insulin receptor substrate 53 kDa, isoform B (A8JNR3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEAEEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQSGTGDIGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQKAVSTMKKQRKKKATPENTEKELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLERQCSIAKHWMVYHTTGKTVIDNNFENWQEIAASREIIPPAAYESGYSTSNGHNNNNISSSSSSGNNNTSGNMRRLERIKDGDDDHLQGHGAQLKKSRSIDAPYGDMRTLHERENLSGLGGTGPAHYAQNSLPRAKSDFNLALVGTGQSSANKHKIIEEQLATLGDDQRGDQRPLVKALYAYMPSGENQLSFEEGDRIALVGGKAKGWQFGENLRTQHFGWFPVAYTNAEVAEVTTSGGRRYENMLMSYERNGGGSGSGSGGGGLRSYQQQQDYEAQLELMESHEATYRRRRNHSAEDSSPTRMFGDTIKQQKKYRPGSGANPRPGPPPTLPAPVPNGPQSQSSRMLNSSQSFCASNGGGVNAAVERRKQKLLNGVQSSKNHPSGKSGVAAKTSLHSSNDSGFANEPPPQPEVDYSDEEPATQRVAIRSRGIYRNYSIDY
Protein: CLIP domain-containing serine protease B14 (EC 3.4.21.-) [Cleaved into: CLIP domain-containing serine protease B14 light chain; CLIP domain-containing serine protease B14 heavy chain] (Q9NAS8)
Organism: Anopheles gambiae (African malaria mosquito)
Function: Serine protease (By similarity). Plays a role in innate immunity against infections by parasite P.berghei and by Gram-negative bacteria such as E.coli. In response to P.berghei infection, contributes to the clearing of parasite ookinetes independent of melanization, an innate immune response which consists in the deposition of melanin pigments on invading pathogens and parasites. May play a role in non-septic wound healing.
Subcellular location: Secreted {ECO:0000269|PubMed:16188883}. Note=Secreted in the hemolymph. {ECO:0000269|PubMed:16188883}.
Interaction partners:
Sequence:
MYSRRYVACGLLCLLVIAIDQGHGQEHKPCTTPNGTAGRCVRVRECGYVLDLLRKDLFAHSDTVHLEGLQCGTRPDGGALVCCPAFVNEPNCGPSVFGVRIIGGNDTELGEFPWMALLRFQARNRKIHGNCGASLVSKRFVLSAAHCFTAAKSKGWKIHSVRVAEWNFMNHRGSKDCKQVKGYDVPICRKDYDVARFVQHPEYRVNAGVHVNDIVLIELAADVEYNVFVAPICLPVSNDTAQLPWGSSDDPEIEYTAAGWGSTESGKESTGMSYQLKQINLRAFNKERCKKLFQVPSGVGVGLGHICAGGIRDEDTCHGDSGGPLMEAVGGVWYLAGITSFGWPRCGRDGVPGVYTNISHYMGWLEREMFRGILA
Protein: Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9) (A1ZB42)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 1
Sequence:
MMDLSPNNQIEDRKPILTADGLVQTSNSPFEPTISQETQTSNGIGGQCHLTVDQLDIEILPIIYDIVRCVEKDPLENAVKLRESQDCNHKIFELQKRFESAREQIRQLPGIDFNKEEQQQRLELLRNQLKLKQQLIRKYKDTEF
Protein: Uncharacterized protein, isoform A (A1Z957)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLDTKWPPLLLLLMLLGQQLQAFDYCDPTLCPGPERHIACNNFGALADICSPDAHIVRITTARRTMILNELNEYRDRIARGDLMGFSPATRMATLQWDQELASFAELNVKRCALVNDHCRNSEQFRNVAQVVAEGGWQGDPLPPSSPSDPPNPEAPIPVEYHTEDEVIKATLEQMFAEYKECSMRDIIAFSPPNNSKCIAYFTQLVRDSTTHVGCGILRQTKNTTNEAGQSLSSVHQYMTCNFVRTNDVNAPVYQSGDRPATECRSGRNPVFINLCSVNEIYDSSNLAGLF
Protein: Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) (SynDIG4) (Q6MG82)
Organism: Rattus norvegicus (Rat)
Function: Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26660156, ECO:0000305|PubMed:22632720}; Single-pass type II membrane protein {ECO:0000305|PubMed:26660156}. Synapse {ECO:0000305|PubMed:22632720}.
Interaction partners:
Sequence:
MSSEKSGLPDSVPHTSPPPYNAPQPPAEPPIPPPQTAPSSHHHHHHHYHQSGTATLPRLGAGGLASAAAGAQRGPSSSATLPRPPHHAPPGPAAGAPPPGCATLPRMPPDPYLQETRFEGPLPPPPPAAAAPPPPAPAPTAQAPGFVVPTHAGAVGTLPLGGYVAPGYPLQLQPCTAYVPVYPVGTPYASGTPGGPGVTSTLPPPPQGPGLALLEPRRPPHDYMPIAVLTTICCFWPTGIIAIFKAVQVRTALARGDLVSAEIASREARNFSFISLAVGIAAMVLCTILTVVIIIAAQHHENYWDP