wanglab/gogpt-training-data huggingface dataset:
Protein: GIGYF family protein Gyf (Gigyf) (Q7KQM6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In the 4EHP-GYF2 complex, promotes translational repression and decay of mRNA targets by recruiting and bridging the association of the 4EHP complex with decapping effector proteins, such as me31B and Patr-1, and the deadenylation CCR4-NOT complex. Involved in regulating starvation-induced, developmental and physiological autophagy, which is critical for eliminating ubiquitinated proteins and dysfunctional organelles in order to maintain tissue homeostasis.
Interaction partners:
- ATP-dependent RNA helicase me31b
- LD06925p
- Eukaryotic translation initiation factor 4E homologous protein, isoform B
- Eukaryotic translation initiation factor 4G1, isoform B
- Protein Gawky
- Eukaryotic translation initiation factor 4E1
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
Sequence:
MTDSMKFGPEWLRNMSAEPSGSPSTYNVGNAAQNNSIGGHNLGNNTAASASRNLFPEYRYGREEMLSLFDRNCLLPQILPSFKKLFVEKVQCPLALTPSSEEDINQNSLGNNSRPAWLQRSPSGFGSASRGSGRGGTVDRGRMRGKSAYHPIYQRPSGLYDESLSVISKAERTWSDRNGTGDSAATTTSTSGSGALDWNGTPSSSPRKDYSNNHRNLENWRRTRNEDGSGDGPSSSGSMSGPDIAGWRSGVVGGSTNAGFGTNSHRWGRSTSWRDEDPSVDNAASLQRSISTVATLSTDRTGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDADENLPEWAIENPSKLGGSFDASGAFHGDTDLKPIKSSHNTLKTKSLDSYDDVKRPKSKDLSDPDSGNDITPETSLTKDTNTTAVQEEVESSLSPISSTTTKEVIHGDISDRIKEVADEVEKLIMDDDHKISSNQSQHQNHDGFTAALPRMADIEINVKPSVTAVHRQAPSTMPIQITPTITDVAPPSHAVVSFSDHETMQHHNMHHLPQFPMIPTPHIITPNLNELWFYRDPQANVQGPFSAVEMTEWYRAGYFNENLFVRRYSDNRFRPLGELIKFCHGNMPFTHSHLLPSPIELENIPVGQIPAPLTASLSITPHKPSPIPIALSVVEQQLQQQRDEQLKANVTATAEALRAAIKGSFGGNSIGNTSHLLTMRFQMLQDQYIQHQEYQILAELSKNECFQRLSAVEQETVVRRKVQLLGLPEYLISLNGLSNSLSVLNPVAGRQLYRAVVEHAKKDQQHIFANTEQQRSVGNLLDANNFILNAQIMIQQSQQEVGPLVSSVDCIMQGGTAADLNKPNEIPRNELDLINEYNLRMLLRGQPTSTQQQPPALTNSATENLPGVDFLTETQLLERQNLMIPIWLPPNNNKQQETDQQWAEMSNADASLWETANLNEERNEDQQLLIQKSSEACFADTEKDVKIAQLFQVQSGNVVNHTALEELDQSPQNLKGSHNQKIVKSLVSDIQQNHNEELNSHQHQVKQANKQNLNTKQNAAQSALKPINNENDRKREQTEEKKRQREERKRQQLEDDKRRALNESEEQTRQIQEEKERQQQIQAQRRKALLGNVHSLSVQNGMSGTLASAQSKKNDDAKTAEPQVSSRLPSTSVAPWSFQLQNSMRSAPGLAEIQKAERRERRADQQRHQELLDKQLRANAAAAAEANDALLKWQSTPASAPVMSLAEIQAEEARRLANDLVDRQRRRELEHHQQAPLSSAVLVTSATSNIWGNANKAWSSSAAQSLSLKTSSGTGLWDEPNPLGSNGSGTSGTSSVTAAAVLAGGLNSANKSTLQAQNKSSALFASPRNLRKSQTLPALSNPEKSNKNGPGQRPEKQKLAQTRSKGAAVSIEEKDRERKLNAKSQQSSTDQAISKVNEYENEFTSWCIKSLDNMSAKVDVPTFVAFLQDLEAPYEVKDYVRIYLGDGKDSLDFAKQFLERRSKYKSLQRAQKAHNDDMCKPAPAITPSANDYADSKNKQKKIKKNKMTKMDARILGFSVTAAEGRINVGIRDYVEGP
Protein: Conserved hypothetical ala-, pro-rich protein (O06556)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved ala-, pro-rich protein
- Possible Inv protein
- Polyribonucleotide nucleotidyltransferase
- Polyprenol-phosphate-mannose-dependent alpha-
- Exported repetitive protein
- Enolase
- Proline-rich 28 kDa antigen
- Putative peptidoglycan hydrolase Rv2525c
Sequence:
MPTIWTFVRAAAVLVGSSAALLTGGIAHADPAPAPAPAPNIPQQLISSAANAPQILQNLATALGATPPLSAPKVAEPAPAAPGITATFPGLTPAAPAAAAAPALTPSIPGVNAPIPGITPAAPALPVTAPAAAPTIPGVNAPIPGITAPAPAAAAVPASVPGVPSAKVDLPQLPYLPLQVPQQLSLPADLPALASGVIPAAPIAPTPPAPGAPALPPGPPSLLAALP
Protein: Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (DmIpk1) (InsP5 2-kinase) (Q9W2Q7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Contributes to the formation of Ins(1,2,3,4,5,6)P6 (InsP6, IP6 or phytate). Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form InsP6 (Probable). Together with Ipk2, they are the main contributors to higher InsP synthesis.
Interaction partners:
- Kinase
- Kinase
Sequence:
MTAERGPRSPGTGQKLRLRATEPMPQWTAKNLHALLDLPAAMELRQIELIYRAEGNANLVLALPQFKKVLRLPKMISSRLRQAAHQRHELADEVARPEGQRVSSERAGTENAGDLTMPDFMAYIGIMRRLLGNEFVCGADIVAIPKEDDRFWINEHIRAQRPVSRLDKEFVGPFGLLLPDVTQLPATFDVLLANLQAKGTTGDESGAAAGVGDGGGVGRGAGTRTKNRSAVRRLGDTYAIEIKPKQGWLQLASDVNDLFDLMPSGAVTKPKETTCNQEENEPSARDKCWCRFCSMQLLKMHNGKIKRLGHYCPLDLFSGTPSRMLDALDALLACPQNNLRVFQNSNLIYGDHANSISFDELSSRVFPGEIMVLIKHLLVACLLREYEHPESKRAEGSNQSQKQQQEQPEPEQLNQSRVSIAATETKAGAAGIGAANVVLPLGGRAAAPVVTAGQSSTRTRAAAATATTQRYTKVARVETTITRQAATSMAAGPASSSQLSGNVLATATATATATAMATSGRTETKTEPETPAEAASTTSRNVNQNESQKLNRNEPANQTQAQNNKTEIFRLPKNCVLQKILNLQLLVKVSQPIKLLPKLLSLCPFGFVYSACPPENLGNCR
Protein: Large ribosomal subunit protein bL12m (54S ribosomal protein L12, mitochondrial) (Mitochondrial-nucleoid protein 1) (P53163)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:15221522, ECO:0000269|PubMed:19756047}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL32m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL36m
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL33m
Sequence:
MSLRILAKRSSSIWMKTRVTPALISPITITTRFNSTTTTAPSHKDDVRPVDPKISKIVQDISQLTLLETSSLINELKTVLNIPEISMPMGGFMAGAAGAGAGNVPSSTGEAGSGAEEEAKPEAKTVFTVKLDSFDTKTKAKVIKEVKGLLGLSLVEAKKFVEAAPKVLKENVAKDDAEKIKKTLEDLGAKVSLE
Protein: Protein kinase superfamily protein (F4HSH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}.
Interaction partners:
Sequence:
MGCFGCSKKSSKRSETNKDTVINRKIVGGTTSVAKSDKRDDQTQPSSDSTKVSPYRDVNNEGGVGKEDQLSLDVKGLNLNDQVTGKKAQTFTFQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNGVQGIREFVVEVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGPSGDKTHVSTRVMGTYGYCAPDYAMTGQLTFKSDIYSFGVVLLELITGRKAIDNTKTRKDQNLVGWARPLFKDRRNFPKMVDPLLQGQYPVRGLYQALAISAMCVQEQPTMRPVVSDVVLALNFLASSKYDPNSPSSSSGKNPSFHRDRDDEEKRPHLVKETECEGRTGNTRRGIFPVSEYWIHAIPVIVFLCFFTLWIFSHSVSVMNDGEIMSIHRLEKSMAVRNESHVSLAILASSAVSPASSALVAVVSTNQNLTTFHNATQSQQNATQSVNKAKQPHAV
Protein: Myosin-1 (Class I unconventional myosin) (Type I myosin) (Q2US45)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, actin patch {ECO:0000250}. Note=Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing hyphal tips and sites of septum formation (By similarity). {ECO:0000250}.
Interaction partners:
- Actin associated protein Wsp1
- Calmodulin
- WH2 domain-containing protein
- UNC-45/Cro1/She4 central domain-containing protein
- High osmolarity signaling protein SHO1
- DUF1348-domain-containing protein
- Elongation factor 3
- rRNA-processing protein cgrA
- Actin binding protein
- Calmodulin
Sequence:
MGHSRRPVGGEKKSRGFGRSKVADVGDGRQAGKPQVKKATFETTKKKDIGVSDLTLLSKISNEAINDNLKLRFEHDEIYTYIGHVLVSVNPFRDLGIYTDNVLDSYRGKNRLEVPPHVFAVAESSYYNMKSYKDNQCVIISGESGAGKTEAAKRIMQYIASVSGGSDSSIQQTKDMVLATNPLLESFGNAKTLRNNNSSRFGKYLELEFNANGEPVGANITNYLLEKSRVVGQIANERNFHIFYQFTKAAPQKYRDMFGVQQPQSYLYTSRSKCFDVPGVDDNAEFRDTLNAMGVIGMSEAEQDNVFRMLAAILWIGNVQFAEDDSGNAAISDQSVVDFVAYLLEVDPAQVNKALTIRIMETARGGRRGSVYEVPLNTVQALAVRDALSKAIYFNLFDWIVERVNQSLTAREPVANSIGILDIYGFEIFEKNSFEQLCINYVNEKLQQIFIQLTLKAEQDEYAREQIQWTPIKYFDNKVVCSLIEDKRPPGVFAALNDACATAHADSGAADNTFVGRLNFLGQNPNFENRQGQFIVKHYAGDVSYSVEGMTDKNKDQLLKDLLNLVGSSGNQFVHTLFPNQVNQDDKRRPPTASDKIKASANDLVATLMKAQPSYIRTIKPNDNKAPREYNVGNVLHQIKYLGLQENVRIRRAGFAYRQTFNKFVERFYLLSPKTSYAGDYTWTGDAESGARQILKDTSIPAEEYQMGITKVFVKTPETLFALEAMRDRYWHNMAIRIQRAWRNYLRYRIECAIRIQRFWRRTTGGLELLKVRDQGHQVLQGRKERRRMSLLGSRRFLGDYLGIGNKGGPGEMIRNGAGISGSDDILFSCRGEVLISKFGRSSKPSPRILVLTNRHVYIVAQILVNNQLQISAERTVPIGAIKAVSTSNLKDDWFSLIIGGQEPDPLINCVFKTEFFTHLQTALRGQLNLKVSENIEYNKKPGKLATVKAIKDPAASPNVDTYKSHTIHTSPGEPPSSVSKPTPKAKQVAARPVTKGKLLRPGGPGGGPSKLASRPASRPTPKPQPLPQSQPATAQPIPAPQPAAVPRPVPQPVAAAAASHTRNASSGSVRAPPPPPPASPPAPKKATAKALYDFTSAQSNELDIRAGDVVQIVSKEGNGWWLCMNMATSVQGWTPQAYLEEQVAPTPKPAPPPPPPAAPRASPVPSANGAAATAAAAKAKPAPPAPPAKRPNMAGRKAVPAPPPAPRDSAVSMNSQDSSGGSGRGTPNSTSNASLAGGLAEALRARQHAMQGKHDDDDEW
Protein: General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit) (TFIIH subunit p8) (Q5ZKH0)
Organism: Gallus gallus (Chicken)
Function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8K2X8}. Cytoplasm {ECO:0000250|UniProtKB:Q8K2X8}.
Interaction partners:
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- Uncharacterized protein.
- Uncharacterized protein.
- General transcription factor IIH subunit
- Cyclin dependent kinase 7
- Cyclin H
- DNA repair protein complementing XP-A cells homolog
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIE subunit 1.
- RAD23 homolog A, nucleotide excision repair protein.
Sequence:
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDLDETHVFVLAELVNFLQERVGELMDQNSFPITQK
Protein: Phytanoyl-CoA hydroxylase-interacting protein-like (Q96FC7)
Organism: Homo sapiens (Human)
Function: May play a role in the development of the central system.
Interaction partners:
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Sequence:
MEVPRLDHALNSPTSPCEEVIKNLSLEAIQLCDRDGNKSQDSGIAEMEELPVPHNIKISNITCDSFKISWEMDSKSKDRITHYFIDLNKKENKNSNKFKHKDVPTKLVAKAVPLPMTVRGHWFLSPRTEYTVAVQTASKQVDGDYVVSEWSEIIEFCTADYSKVHLTQLLEKAEVIAGRMLKFSVFYRNQHKEYFDYVREHHGNAMQPSVKDNSGSHGSPISGKLEGIFFSCSTEFNTGKPPQDSPYGRYRFEIAAEKLFNPNTNLYFGDFYCMYTAYHYVILVIAPVGSPGDEFCKQRLPQLNSKDNKFLTCTEEDGVLVYHHAQDVILEVIYTDPVDLSVGTVAEITGHQLMSLSTANAKKDPSCKTCNISVGR
Protein: MIP10861p (Q9W4B1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- IP03738p
- Myosin regulatory light chain sqh
- MIP03207p
- Myosin regulatory light chain 2
- Myosin heavy chain, muscle
- Myosin heavy chain-like, isoform B
- Myosin heavy chain, non-muscle
Sequence:
MLQNFAFENHPTIGFFSKQSELMRMLPEIPKLRNIFDLFVVNECDQAAGGEDVAAPTCLDLGIGIRMTDVADCLRIMGLNPSDDELQQRLEEHVRRRESLGMGMKKIAQRATFELVLTLYCQLAEQEVKEMAKGCIVENVLRVLRSRDSAGTGMLPYSQLRHLLTTMGNRLDETEVYGVLHRAADINGNVLYEHLVHQLFATDPLAEERLQQAQLYLQAVGRNAIDMDMDKRDEFIDAIRRADPARSGFIEPQRLLELLNRNGEQFTGEELQLLIQGMEDTRCKRGINYCRFLEFIMNE
Protein: Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein) (Q8NEJ9)
Organism: Homo sapiens (Human)
Function: Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9DB96}. Nucleus, nucleolus {ECO:0000269|PubMed:18547334, ECO:0000269|PubMed:34516797}. Chromosome, centromere {ECO:0000269|PubMed:18547334}. Cytoplasm {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, axon {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9DB96}. Note=Translocated from nucleolus to nuclear foci in response to UV damage (By similarity). Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites. {ECO:0000250|UniProtKB:Q9DB96}.
Interaction partners:
- WD repeat-containing protein 46
- KRR1 small subunit processome component homolog
- Nucleolar complex protein 4 homolog
- U3 small nucleolar RNA-associated protein 4 homolog
- U3 small nucleolar RNA-associated protein 6 homolog
- U3 small nucleolar RNA-associated protein 18 homolog
- Protein AATF
- Nucleolar protein 10
- Probable U3 small nucleolar RNA-associated protein 11
- WD repeat-containing protein 36
Sequence:
MAALGVLESDLPSAVTLLKNLQEQVMAVTAQVKSLTQKVQAGAYPTEKGLSFLEVKDQLLLMYLMDLTHLILDKASGGSLQGHDAVLRLVEIRTVLEKLRPLDQKLKYQIDKLIKTAVTGSLSENDPLRFKPHPSNMMSKLSSEDEEEDEAEDDQSEASGKKSVKGVSKKYVPPRLVPVHYDETEAEREKKRLERAKRRALSSSVIRELKEQYSDAPEEIRDARHPHVTRQSQEDQHRINYEESMMVRLSVSKREKGRRKRANVMSSQLHSLTHFSDISALTGGTVHLDEDQNPIKKRKKIPQKGRKKKGFRRRR
Protein: V-type proton ATPase subunit d 2 (V-ATPase subunit d 2) (Vacuolar proton pump subunit d 2) (Q5FVL0)
Organism: Rattus norvegicus (Rat)
Function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Regulator of osteoclast fusion and bone formation (By similarity).
Interaction partners:
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase subunit a
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase 16 kDa proteolipid subunit c
- V-type proton ATPase subunit B, brain isoform
- Vacuolar proton pump subunit B
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit E 1
- V-type proton ATPase subunit a
- V-type proton ATPase subunit D
Sequence:
MLETAELYFNVDHGYLEGLVRGCKASLLTQQDYVNLVQCETLEDLKIHLQTTDYGNFLAHETNPLTVSKIDTEMRKKLCREFDYFRNHSLEPLSTFFTYMTCSYMIDNIILLMNGALQKKSVKEVLAKCHPLGRFTEMEAVNIAESASELFKAVLVETPLAPFFQDCMSENTLDELNIELLRNKLYKSYLEAFYKFCKDHGDVTAEVMCPILEFEADRRALIITLNSFGTELSKEDRETLFPTCGKLYPEGLRLLAQAEDFEHMKRVADNYGVYKPLFDAVGGSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYVKLKEQEMRNIVWIAECISQRHRTKINSYIPIL
Protein: Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)] (Q42586)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Dihydroorotate dehydrogenase
- UMP kinase
- Aspartate carbamoyltransferase, chloroplastic
- Dihydropyrimidine dehydrogenase
- Uracil phosphoribosyltransferase, chloroplastic
- Carbamoyl phosphate synthase small chain, chloroplastic
- Carbamoyl phosphate synthase arginine-specific large chain, chloroplastic
- Uridine/cytidine kinase UKL1, chloroplastic
- Uridine/cytidine kinase UKL1, chloroplastic
- Uridine kinase-like protein 4
Sequence:
MSAMEALILQLHEIGAVKFGNFKLKSGIFSPVYIDLRLIVSYPSLLTQISQTLISSLPPSATFDVVCGVPYTALPIATVVSVSNGIPMLMRRKEIKDYGTSKAIEGIFEKDQTCLIIEDLVTSGASVLETAAPLRAVGLKVSDAVVLIDRQQGGRENLAENGIKLHSMIMLTDMVRVLKEKGKIEVEVEVNLLKFLEENRRVSVPSVEKPKPKPRVLGFKERSELSKNPTGKKLFDIMLKKETNLCLAADVGTAAELLDIADKVGPEICLLKTHVDILPDFTPDFGSKLRAIADKHKFLIFEDRKFADIGNTVTMQYEGGIFKILEWADIINAHVISGPGIVDGLKLKGMPRGRGLLLLAEMSSAGNLATGDYTAAAVKIADAHSDFVMGFISVNPASWKCGYVYPSMIHATPGVQMVKGGDALGQQYNTPHSVITERGSDIIIVGRGIIKAENPAETAHEYRVQGWNAYLEKCSQ
Protein: Peter pan protein, putative (Q57ZM9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- RNA processing factor 1, putative
- Uncharacterized protein
- rRNA processing protein, putative
- Ribosome biogenesis protein NSA1
- Pescadillo homolog
- Protein MAK16 homolog
- Nucleolar complex protein 2
- Nucleolar GTP-binding protein 1
- ATP-dependent DEAD/H RNA helicase, putative
Sequence:
MGKSKKMPGTVDTTEADKATPKSIIIYRGEVGGSVRSLMHDWRAVFLPWSSKKLRGENRSLKDFLVIASSLSVSHLQLFTAPSYGTSLRIMRFSNGPTLTFRVLSFTLRDEIVAKQRRPANLGNAVWNVAPIVVLNNFTHPDARLRPEVPLLETTFKGMFPTVNIQLVKNTDIQRVCLFHYDHVEHVVEVRHYYINAKAVGVSKTVKKLLERRCPTKLGQLESIDEVLEREDVWSDTDGEGEEVPLAVPFRKHREQCRIKLQEIGPRLTLQLVKVTNGFATGEVLFHRFLRKSAELVARDEARVRAKRNERAKRKAEQDENVARKKSKREERLQAKRQRREEAMRQQVENPLEVADGGYGADMD
Protein: Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) (Q9JHJ0)
Organism: Mus musculus (Mouse)
Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Alpha-adducin
- Gamma-adducin
- Beta-adducin
- Dematin
- Actin, cytoplasmic 2
- F-actin-uncapping protein LRRC16A
- Tropomyosin alpha-3 chain
- Nebulin
- KICSTOR complex protein kaptin
- Actin-related protein 2/3 complex subunit 2
Sequence:
MALPFRKDLGDYKDLDEDELLGKLSESELKQLETVLDDLDPENALLPAGFRQKNQTSKSATGPFDRERLLSYLEKQALEHKDRDDYVPYTGEKKGKIFIPKQKPAQTLTEETISLDPELEEALTSASDTELCDLAAILGMHNLIADTPFCDVLGSSNGVNQERFPNVVKGEKILPVFDEPPNPTNVEESLKRIRENDARLVEVNLNNIKNIPIPTLKDFAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLMELKIDNQRQQLGTSVELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNNDLVRKRRIEGDHQ
Protein: Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6) (Q92581)
Organism: Homo sapiens (Human)
Function: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo. Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH. Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity).
Subcellular location: Endosome membrane {ECO:0000269|PubMed:11641397, ECO:0000269|PubMed:11940519}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:11940519, ECO:0000269|PubMed:18057008, ECO:0000269|PubMed:28635961, ECO:0000269|PubMed:30296617, ECO:0000269|PubMed:32277048}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:11940519, ECO:0000269|PubMed:28635961}; Multi-pass membrane protein. Late endosome membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:11940519, ECO:0000269|PubMed:28635961, ECO:0000269|PubMed:30296617}; Multi-pass membrane protein {ECO:0000255}. Note=Present predominantly in the recycling compartments including early and recycling endosomes, but undergoes plasma membrane localization during vesicular recycling, which is enhanced upon certain stimuli, such as hypoxia (PubMed:11940519, PubMed:28635961, PubMed:30296617). Has a major plasmalemmal distribution in a few specialized cells, such as in vestibular hair bundles and osteoblasts (By similarity). {ECO:0000250|UniProtKB:A1L3P4, ECO:0000269|PubMed:11940519, ECO:0000269|PubMed:28635961, ECO:0000269|PubMed:30296617}.
Interaction partners:
- Sodium/hydrogen exchanger 7
- Sodium/hydrogen exchanger 9B2
- Divergent protein kinase domain 2A
- Small ribosomal subunit protein RACK1
- Neuronal PAS domain-containing protein 4
Sequence:
MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
Protein: Golgi-associated plant pathogenesis-related protein 1 (Im:7150988) (A0A0R4IVU8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Phosphoribosylglycinamide formyltransferase.
Sequence:
MAGASFKQEFLQTHNQYRHQHQAPPLVYREDLCRAAQKWAEHMLSKKSLGHSETENGENVYYSFSSVKKTPTGKEAVDSWYSEIKDYNFAKSGHQPKTGHFTQVVWKSSKELGVGLATDGNTVFVVGQYKPAGNITNAGYYEQNVLPKKQ
Protein: Alpha-centractin (Centractin) (P85515)
Organism: Rattus norvegicus (Rat)
Function: Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15057822}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P61163}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P61163}.
Interaction partners:
- Dynactin subunit 2
- Actin-related protein 10
- Dynactin subunit 6
- Dynactin subunit 1
- Dynactin subunit 4
- Dynactin subunit 3
- Dynactin subunit 5
- Actin, cytoplasmic 1
- Beta-centractin
- Cytoplasmic dynein 1 heavy chain 1
Sequence:
MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGPKAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKNRERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDIAGRDVSRFLRLYLRKEGYDFHSSSEFEIVKAIKERACYLSINPQKDETLETEKAQYYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGARSIHRKTF