wanglab/gogpt-training-data huggingface dataset:
Protein: CRISPR-associated endonuclease Cas9/Csn1 (EC 3.1.-.-) (SpCas9) (SpyCas9) (Q99ZW2)
Organism: Streptococcus pyogenes serotype M1
Function: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA; Cas9 only stabilizes the pre-crRNA:tracrRNA interaction and has no catalytic function in RNA processing. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). The target strand not complementary to crRNA is first cut endonucleolytically, then trimmed 3'-5' exonucleolytically. DNA-binding requires protein and both gRNAs, as does nuclease activity. Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. DNA strand separation and heteroduplex formation starts at PAM sites; PAM recognition is required for catalytic activity. Confers immunity against a plasmid with homology to the appropriate CRISPR spacer sequences (CRISPR interference).
Interaction partners:
Sequence:
MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD
Protein: Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) (P07355)
Organism: Homo sapiens (Human)
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
Interaction partners:
- Protein S100-A4
- Protein S100-A10
- Neuroblast differentiation-associated protein AHNAK
- Tissue-type plasminogen activator
- Plasminogen
- Annexin-2 receptor
- Protein S100-A11
- Annexin A1
- Dysferlin
- CD63 antigen
Sequence:
MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
Protein: UDP-2,3-diacylglucosamine pyrophosphatase LpxG (UDP-DAGn pyrophosphatase) (EC 3.6.1.-) (UDP-2,3-diacylglucosamine hydrolase LpxG) (UDP-DAGn hydrolase) (O84467)
Organism: Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx)
Function: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to form 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipooligosaccharide (LOS) to the outer membrane of the cell. Can functionally complement lpxH deficiency in E.coli. Overexpression of LpxG results in toxic accumulation of lipid X and profoundly reduces the infectivity of C.trachomatis. Can utilize UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine as substrate in vitro, but the substrate is likely UDP-2-N-((3R)-3-hydroxyicosanoyl),3-O-(tetradecanoyl)-alpha-D-glucosamine in vivo.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:27006461}; Single-pass membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000305|PubMed:27006461}.
Interaction partners:
- Tetraacyldisaccharide 4'-kinase
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- tRNA pseudouridine synthase A
Sequence:
MFVSVGITASLTTILAAPVLTWVWANHLEPNLLRVTRLNWNLPKKFAHLHGLRIVQISDLHLNHSTPDAFLKKVSRKISSLSPDILVFTGDFVCRAKVETPERLKHFLCSLHAPLGCFACLGNHDYATYVSRDIHGKINTISAMNSRPLKRAFTSVYQSLFASSRNEFADTLNPQIPNPHLVSILRNTPFQLLHNQSATLSDTINIVGLGDFFAKQFDPKKAFTDYNPTLPGIILSHNPDTIHHLQDYPGDVVFSGHSHGPQISLPWPKFANTITNKLSGLENPELARGLFSFPEESRLLYVNRGLGGWKRIRFCSPPEICLMRCLYEP
Protein: Large ribosomal subunit protein eL33 (60S ribosomal protein L35a) (O55142)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}.
Interaction partners:
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein eL30
- Small ribosomal subunit protein eS8
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein uL10
- Ubiquitin-ribosomal protein eS31 fusion protein
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein eS1
Sequence:
MSGRLWCKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI
Protein: Cytochrome b561 and DOMON domain-containing protein At3g25290 (Protein b561A.tha3) (Q9LSE7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a catecholamine-responsive trans-membrane electron transporter.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Sphinganine C4-monooxygenase 1
- Protein DETOXIFICATION 34
- Uncharacterized protein At3g28850
- Serine decarboxylase
- Mitochondrial uncoupling protein 5
- Large ribosomal subunit protein uL23m
- Pollen-specific leucine-rich repeat extensin-like protein 3
Sequence:
MSSSSSVRISLSFIFLALLISPAVSQTCKSQTFSGDKTYPHCLDLPQLKAFLHYSYDASNTTLAVVFSAPPAKPGGWIAWAINPKATGMVGSQTLVAYKDPGNGVAVVKTLNISSYSSLIPSKLAFDVWDMKAEEAARDGGSLRIFARVKVPADLVAKGKVNQVWQVGPELGPGGMIGRHAFDSANLASMSSLDLKGDNSGGTISGGDEVNAKIKNRNIHGILNAVSWGILFPIGAIIARYMRVFDSADPAWFYLHVSCQFSAYVIGVAGWATGLKLGNESEGIRFSAHRNIGIALFTLATIQMFAMLLRPKKDHKYRFYWNIYHHGVGYAILTLGIINVFKGLNILKPQDTYKTAYIAVIAVLGGIALLLEAITWVVVLKRKSNNSMKPLRT
Protein: FI03607p (Ring finger and CHY zinc finger domain containing 1, isoform A) (Ring finger and CHY zinc finger domain containing 1, isoform B) (Q9VMD4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- DNA polymerase eta
- LD47387p
- Uncharacterized Golgi apparatus membrane protein-like protein CG5021
Sequence:
MKNRQRTRRISLNENHNRYMGSGGIDVQIVTNTKEPNQVNLNSSSATTTSAEAALPASLPLAQIAQQPHTHPHPHPNPHLHQQHQLIVTPTTMTGKYHPAHAKLRRCKSTPSLNCDGMAEPMEEDQLHRFAACSRNPAAEAQQHAQPSCNSSSSSSDGSCNSNKCSSNICGAQPTTPESLRFGCAHYKRRAMFVTPCCNKFYKCRFCHDENETHHFDRKTLTELICSECNTRQTVREQCLNCGVRFGKYTCLICNLFDDADKQQYHCHGCGICRIGGAENFFHCEVCNMCLPIQLKIDGHRCVENISRSHCPVCLGDIHTSRIPCHIPDCGHLLHKMCFDQLLASGHYTCPTCQTSLIDMTALWVYLDDQAERMPVPLKYENQRVHIFCNDCHKTSKTKFHFIGLKCVHCGAYNTTQDVKRRLSLVTDEPSSA
Protein: Transmembrane protein 120B (A0PK00)
Organism: Homo sapiens (Human)
Function: Necessary for efficient adipogenesis. Does not show ion channel activity.
Subcellular location: Nucleus inner membrane {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acetoacetyl-CoA synthetase
Sequence:
MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLTLQRCKRHASREEAELVQQMAANIKERQDVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLAFTFLILFLGNFLTTLKVVHAKLQKNRGKTKQP
Protein: LD05057p (Taspase 1, isoform A (EC 3.4.25.-)) (Taspase 1, isoform B) (Q9VUX9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Retinoblastoma-binding protein 5 homolog
- Histone-lysine N-methyltransferase trithorax
Sequence:
MAGFVAVHTGAGNCIDETKYQRVIKEACLRATEILRNGGSAVDACEAAIVRLENCGYTNAGYGSNLCMDGSVQCDAAIMDGSTLNFGACTNVSRVKNPIQLARRICDAQSSPQLLERIPPMILAGTGAEHYADEVGCSMVEPGVLISSKAKFQFNHYKSKYDLVVNSRLGKATSEESVQVPEPGNEVELAAALDTVGAVCVDGAGNTAAGCSSGGILLKVPGRVGQAATYGAGCWATDTDELAIATCTTGNGEYLMKTLLAREICHGAFSSDCAVTSLHKTFKQKFLDSPLLPRQQDLYAGALTLLYYPGQSSGEVMWSHTTQSFCVGYMATNQRVPKFVHSPLPTYSVPGRSCVVNGHNFHLRI
Protein: Outer-membrane lipoprotein LolB (P42812)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
Subcellular location: Cell outer membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Interaction partners:
- Outer-membrane lipoprotein carrier protein
- TPR repeat-containing protein PA4667
- Lipoprotein-releasing system ATP-binding protein LolD
- Outer membrane protein assembly factor BamD
- LPS-assembly lipoprotein LptE
- 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
- Outer membrane protein assembly factor BamE
- LPS-assembly protein LptD
- Lipoprotein signal peptidase
- Outer membrane protein assembly factor BamA
Sequence:
MRLRLFLAASALALLSGCAGLTSHEALEGQGDAQTWKTHKQQLSELDAWQIDGKVGIRAPRDSGSGTLFWLQRQGYYDIRLSGPLGRGAARLTGREGAVSLEVAGQGRYQAESPEALLEEQLGWRLPVSHLLWWVRGLPAPDSKSRLTLDADSRLARLEQDGWQIEYTRYAEQNGYWLPERLKLHGQDLDVTLVIKDWQPRQLGR
Protein: Cytohesin 1a (Cytohesin-3 isoform X2) (F1QDR1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDEDNQVPEDLSLEERDELSNIRRRKKELLDDIERLKFEIAEVMTEIEQLTCVGESKTTQRNKQIAMGRKKFNMDPKKGIQFLLENDLLQQTPEDIAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCQCNPGVFQSTDTCYVLSFAIIMLNTSLHNPNVRDKPAVERFISMNRGINDGGDLPEELLRNLYESIKSEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEEPRKPNCFELYNPNHKGQVIKACKTEADGRVVEGNHVVYRISAPTPEEKEEWIKSIKASISRDPFYDMLATRKRRIANKK
Protein: MYC proto-oncogene, bHLH transcription factor (Myc-related translation/localization regulatory factor) (ORF 114) (Q14899)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRCWVILIILGIVFLLMPLSFLPIYTNIPRSERAPINTLLSSTLPGTLDQSAALSPALARRPAAWYARGVAVGAQCVLGVEGSCSACDDLYSQDKDAVCQTVLLRRSSRERERV
Protein: Casein kinase I isoform delta (EC 2.7.11.1) (Protein kinase 20) (Q20471)
Organism: Caenorhabditis elegans
Function: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms (By similarity). Casein kinases are operationally defined by their preferential utilization of acidic proteins (By similarity). Positively regulates the expression of components of the heterochronic pathway, which regulate developmental timing, such as the transcriptional repressor lin-42 and microRNAs such as let-7. Negatively regulates cell cycle exit and cell fusion to prevent the premature differentiation of hypodermal seam cells into adult cells. Plays a role in regulating axon branching and subsequently, the maturation of the nervous system, most likely by preventing the premature termination of transcripts for proteins such as Ankyrin/unc-44, which are required for maintaining the nervous system. May phosphorylate ssup-72 to promote nervous system maturation (Probable).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P48730}. Nucleus {ECO:0000269|PubMed:31910362}. Chromosome, centromere {ECO:0000250|UniProtKB:P48730}. Cell junction, adherens junction {ECO:0000269|PubMed:31910362}. Note=Localizes to the nucleus of all cell types and to adherens junctions in the spermatheca. {ECO:0000269|PubMed:31910362}.
Interaction partners:
- Period protein homolog lin-42
- Protein LTV1 homolog
- Uncharacterized protein byn-1
- Serine/threonine-protein kinase RIO2
- Pre-rRNA-processing protein TSR1 homolog
- non-specific serine/threonine protein kinase
- RNA-binding protein NOB1
- Small ribosomal subunit protein uS3
- RNA-binding protein pno-1
- Small ribosomal subunit protein uS5
Sequence:
MATMSNDAAAAATWHNNTSTPMDTTEPATNSHNPGETAVIGGPEALLLPSGSGPEEMNRHPLLMAQAHGEHHQPRLLHNFPVIPPPIQQHQQPPLLQQAQPSQIPHPTQPQIDPTMFTQQSGFNWPPIDPNTIAALAQAQLASSHAQFVSLALTLDPTLLSHFLATQQIPPVPQPLVHKKAEMELRVGNRFRLGRKIGSGSFGDIYLGQNIQTNEEVAVKLECVKSKHPQLHIESRLYRIMLGGIGIPEIRWCGQEGDYNVMVMELLGPSLEDLFNFCQRKFSLKTVLLLADQMLSRVEFIHCRDYIHRDIKPDNFLMGLGKRGNLVYIIDFGLAKRYRDSKHQHIAYRENKNLTGTARYASINTHRGIEQSRRDDIESLGYVFMYFNRGTLPWQGLKAVTKRQKYELISEKKISTRVDDLCAGYPEAFAQYLNYCRSLGFEEQPDYGYLRNLFRTLFHRQQFCYDYVFDWNTYKFYNESLEARNNFQQAVPNQRRH
Protein: H(+)-exporting diphosphatase (EC 7.1.3.1) (Q57Y42)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MIKMSPLLLKAAVVTACLCSLAVATTVEEQTAPKPIENATTYQQELGGRGKVDSPIAPGDAVSITSGIKVMSVTTATAIIFLASAFGFSFAMYWWYVASDIKITPGKGNIMRNAHLTDEVMRNVYVISKRVSDGANAFLFAEYRYMGIFMLGFGALLYFLLGVAMSSPQGEGKDGRPPVAVEAPWVNAAFSLYAFVIGAFTSVLAGWIGMRIAVYTNSRTAVMATVGSGGSDDDVLANGSQSRGYALAFQTAFRGGITMGFALTSIGLFALFCTVKLMQTYFGDSAERLPELFECVAAFGLGGSSVACFGRVGGGIYTKAADVGADLVGKVEKNIPEDDARNPGVIADCIGDNVGDIAGMGSDLFGSFGEATCAALVIAASSAELSADFTCMMYPLLITAGGIFVCIGTALLAATNSGVKWAEDIEPTLKHQLLVSTIGATVVLVFITAYSLPDAFTVGAVETTKWRAMVCVLCGLWSGLLIGYSTEYFTSNSYRPVQEIAESCETGAATNIIYGLSLGYISVLPPILAMAFTIYLSHHCAGLYGYALAALGILSTMSIALTIDAYGPISDNAGGIAEMAHMGHEIREITDALDAAGNTTAAIGKGFAIGSAAFVALALYGAYVSRVGISTVNLLDARVMAGLLLGAMLPYWFSALTMKSVGVAAMDMVNEIRRQFQDPAVAAGTKEPDYESCVNIATGAALQQMVAPACLVMLAPIVTGILFGRYTLAGLLPGALVSGVQVAISASNTGGAWDNAKKYIEKGGLRDKSKGKGSPQHAAAVIGDTVGDPLKDTSGPALNILVKLMAIISVVFAPVVQSKLGGLLVK
Protein: Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Neural enolase) (NSE) (O57391)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm.
Interaction partners:
- Phosphoglycerate mutase 1
- Pyruvate kinase PKM
- Glucose-6-phosphate isomerase
- Phosphoglycerate mutase
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Phosphoenolpyruvate carboxykinase, mitochondrial
- Phosphoenolpyruvate carboxykinase, cytosolic
- Glycerate kinase
- Fructose-bisphosphate aldolase C
Sequence:
MAVERIHAREILDSRGNPTVEVDLYTHKGMFRAAVPSGASTGIYEALELRDNDKSRFLGKGVLQAVDHINSTVAPAIVGSGLSVVDQEKIDNLMLEMDGTENKSKFGANAILGVSLAVCKAGAAEKDVPLYRHIADLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRIGAEVYHNLKSVIKEKYGKDATNVGDEGGFAPNILENSEALELLKEAIDKAGYTDKIVIGMDVAASEFYRDGKYDLDFKSPDDPSRYISADELGDLYQSFVRAYPVLSIEDPFDQDDWEAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVALCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL
Protein: Mitochondrial import inner membrane translocase subunit TIM21 (Q59VW7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit TIM17
- Mitochondrial import inner membrane translocase subunit TIM23
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM8
- Mitochondrial import inner membrane translocase subunit
- Mitochondrial import inner membrane translocase subunit TIM16
- GrpE protein homolog
- Protein MGR2
Sequence:
MHMIQRVSSIGLRTLRSSNIGSIRSLIVLPILSIKPTYIRQTQAQINLKPQALLLNLLLHHHHHHHHYYSTKTAPPPPPPPQPPQDKNAKGKKILNRINRAFTFSLSTLLVVGAAGISVLVVSLILSELFLPSGDTRTFNKAVKLIEKNEQAQKALNFQSGQRLKAYGIVSADKWVRNRPVQSVKTKRKDGKDHLIMKFQVESDNGKYGVVSLEQIDNSMWNTEFEYISLDVPGFKRIYIIEPPKNQLIPKIGGGSGFLGLNWGPKKD
Protein: U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor) (UTP25 small subunit processor component) (Q6PEH4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing. Essential for embryonic development in part through the regulation of p53 pathway. Required for the expansion growth of intestine, liver and exocrine pancreas, but not endocrine pancreas. May not play a major role during the early stage of endodermal organogenesis. Also involved in the sympathetic neuronal development. Triggers the degradation of p53/TP53 and Delta113p53 isoform in a ubiquitination pathway independent way. Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16322560, ECO:0000269|PubMed:23357851}.
Interaction partners:
- Something about silencing protein 10
- U3 small nucleolar ribonucleoprotein protein MPP10
- Nucleolar protein 6
- WD repeat domain 36
- NOP14 nucleolar protein homolog
- Neuroguidin
- Activator of basal transcription 1
- rRNA biogenesis protein RRP36
- IMP U3 small nucleolar ribonucleoprotein 4)
- Programmed cell death 11.
Sequence:
MGKRRRGKQEIDNLTKKQKKHLKEFGEQHPFHDKVVERPEKTQILRLPDSPQRPEPDSEDDSDAEQPSAYQKLLSTMIQGDEDDVESEDEESEEEDNEEEAEVEGDSEEEVEDTDEEDGNDAEEVLEDKVEETSDKLQKKHPEKTNGDVEENEEAEMEGEFTDKKNEAAFCLETNMPAEGEENTAQQEQDEDMFVKHQEIELSEEEVGRISQGSKVKTQVKWAKLGVLQCMCPLERFPAIGQASSAPLPPIHKTLEANWHLLNLPFGAATDVTELQKEMLGLMGTYRDLYLANLSPLKEAKEVRSAYCLHALNHVLKANSRVLRNNAKLKESKNGDEDFRDQGLTRPKVLILVPFRDGALRVVQTFMTLLEPKGKKTDASNKKRFKEEYGEETDEKPPNLQRPDDYHAVFSGNIDDHFRIGMSILRHSMRLYAPFYSSDIIIASPLGLRTVLGAEGEKKRDHDFLSSIELLIVDQADVFLMQNWEHLLHVLEHLNLQPLDSHGVDFSRVRMWNLNNWAAYYRQTLVFSAIQEPQITNILTKHCHNYRGQVCSKTIPKIGSICQVLVQLPHVFQMFHSDSFMDQDARFQFFVDKILPQYRDSVMSHTFIYVPSYFDFVRLRNYLKKEDVSFANISEYSQRSEVSRARHYFQKGEKQFLLFSERFHFYKRYTIKGIHNLIFYGLPTYPHFYSEVCNMLQAGVREGGASVSFTCTALYSRYDVHRLAAITGADRAAQMLQSKKTTHLFITGEEKST
Protein: Tip elongation aberrant protein 3 (Cell polarity protein tea3) (O14248)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a cell end marker required for efficient new end take-off (NETO), whereby growth is activated at the cell end to generate bipolarity in extending cells. Also required for proper placement of the septum.
Subcellular location: Cell tip {ECO:0000269|PubMed:12007420}. Note=Present at both poles of the cell throughout the cell cycle whether they are growing or not. Located at the division site at time of cytokinesis. {ECO:0000269|PubMed:12007420}.
Interaction partners:
- Tip elongation aberrant protein Tea4
- Tip elongation aberrant protein 1
- DYRK-family kinase pom1
- Kinesin-like protein tea2
- Actin-interacting protein 3 homolog
Sequence:
MVQKVLSRQSDNSQDVSAEQLDVVESGSIDQQNIRAWVVRKVKENDKRTSTNQSFKWEAVKPASCLDAANEKFMYLHGGREKSGISNSLFKLDLDSCTVYSHNRGEDNDSPARVGHSIVCSADTIYLFGGCDSETDSTFEVGDNSLYAYNFKSNQWNLVSTQSPLPSPRTGHSMLLVDSKLWIFGGECQGKYLNDIHLFDTKGVDRRTQSELKQKANANNVEKANMEFDETDWSWETPFLHSSSPPPRSNHSVTLVQGKIFVHGGHNDTGPLSDLWLFDLETLSWTEVRSIGRFPGPREGHQATTIDDTVYIYGGRDNKGLILNELWAFNYSQQRWSLVSNPIPILLSDSSSYKIVSKNNHILLLYLNALDAPKQLLCYEADPKNLYWDKDKFSDIPVLQHISMKPSNASNHTVSLGYLNDRPNHSKKNSVTSTSSSQFNNFLEQNQKAVRSARHRHYASLDEQGLHSLRNLSKTSGMNHSADFSLHEFGQADPFAYEIEKPIASLPLPNGNDTISRSSESSSPINESESNSLLKLQSDFKFSNSDDRVAWLEEQLLYCMQQGYTLKPPNLFQHVDEKLRLEKKEQLSYLEILKVIEQMLESNEQKFKKQIVSLASENAKLAAQRDAAVENANYSRSLIQKKTTDETVGSLIEKVGKLEYEVQGTLEEATSYYQKNTELQQLLKQNESASELLKSRNEKLCVDYDKLRSVFEEDSSKILSLQKENENLQSQILQISEELVDYRSRCEALEYGNYELETKLIEMHDRVEMQTNVIEASASALDVSNTAILSFEDSLRRERDEKSTLQQKCLNLQYEYENVRIELENLQSRALELESALEQSVSDAKYSKAIMQSGLSKLLSSINENKDNLKEFSKSKQKISYLESQLEGLHELLRESQRLCEGRTKELLNSQQKLYDLKHSYSSVMTEKSKLSDQVNDLTEQAKITQRKLSEVQIALADSKMNQQLSGKDSTDVHLPTDFSASSSPLRSYFNEEDSFNNASAAHSSKESDIPSGGVFTKYRNHFGNLMTSEETKAPDNNDLHKRLSDVINSQQKFLSLSPQVSKDYYDVRSKLNDTAGSFSGEEMRAIDDNYYASRIKQLEDDYQKAITYANCSDESFQQLSHSFM
Protein: DNA polymerase sliding clamp 2 (Proliferating cell nuclear antigen homolog 2) (PCNA 2) (Q5JFD3)
Organism: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Function: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
Interaction partners:
- Flap endonuclease 1
- Replication factor C small subunit
- DNA polymerase
- DNA polymerase II small subunit
- DNA ligase
- Replication factor C large subunit
- DNA polymerase II large subunit
- DNA polymerase sliding clamp 1
- DNA primase small subunit PriS
- Replication factor A complex, RPA41 subunit
Sequence:
MTFEIVFDSAREFESLIATLEKFFDEAVFQVNMEGIQMRAIDPSRVVLVDLNLPEMLFSKYSVESEEAIAFDLKRFLKVLKLARSRDTLVLRKGGENFLEVGLLGDENTWFKLPLIDANTPEIEIPSLPWTVKAVVLAGALKRAVKAAKLVSDSIYFMATPEKLTFKAEGNDSEVRTVLTMEDPGLLDLEHKMTKAKSAYGVAYLEDILRSLADADEVIIRFGFDIPLLLKYMVRDAGEVSFLIAPRVEEGRS
Protein: Lipoprotein BsmA (Biofilm stress and motility protein) (P39297)
Organism: Escherichia coli (strain K12)
Function: Involved in protection of biofilms against oxidative stress.
Subcellular location: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
- Uncharacterized protein YjfN
Sequence:
MVSRKRNSVIYRFASLLLVLMLSACSALQGTPQPAPPVTDHPQEIRRDQTQGLQRIGSVSTMVRGSPDDALAEIKAKAVAAKADYYVVVMVDETIVTGQWYSQAILYRK