wanglab/gogpt-training-data huggingface dataset:
Protein: Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) (P26443)
Organism: Mus musculus (Mouse)
Function: Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P00367}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P00367}. Note=Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum. {ECO:0000250|UniProtKB:P00367}.
Interaction partners:
- Glutamine synthetase
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Glutaminase kidney isoform, mitochondrial
- Alanine aminotransferase 2
- N-acetylglutamate synthase, mitochondrial
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Glutaminase liver isoform, mitochondrial
- Receptor-interacting serine/threonine-protein kinase 3
- Omega-amidase NIT2
Sequence:
MYRRLGEALLLSRAGPAALGSAAADSAALLGWARGQPSAAPQPGLTPVARRHYSEAAADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
Protein: 52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (THAP domain-containing protein 0) (THAP domain-containing protein 12) (Q9CUX1)
Organism: Mus musculus (Mouse)
Function: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.
Interaction partners:
- THAP domain-containing protein 7
- DnaJ homolog subfamily C member 3
- Peroxynitrite isomerase THAP4
- THAP domain-containing protein 11
Sequence:
MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIEETSEQEQETNTNAQNPSAEAVNQQDANVLPLTLEEKENKEYLKSLFEILVLMGKQNIPLDGHEADEVPEGLFAPDNFQALLECRINSGEEVLRKRFEATAVNTLFCSKTQQRHMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDDAHNLREEFVGFLPYEADAEILAVKFHTTITEKWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAVYTLCSSCALNAWLAKSVPVIGVSVALGTIEEVCSFFHRSPQLLLELDSVISVLFQNSEERAKELKEICHSQWTGRHDAFEILVDLLQALVLCLDGIINSDTNVRWNNYIAGRAFVLCSAVTDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAASSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAQQGNLESQLTSESYYKDTLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTNKSELPTINSETIENT
Protein: Mitochondrial import inner membrane translocase subunit TIM50 (Q59W44)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM17
- Mitochondrial import inner membrane translocase subunit TIM23
- Mitochondrial import inner membrane translocase subunit TIM21
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit TIM16
- Translocase of outer membrane 40 kDa subunit
- GrpE protein homolog
- Transcription initiation factor IIF subunit alpha
- Mitochondrial import inner membrane translocase subunit
Sequence:
MFRTQSRYLVRSILANHCVLPSTRMAVSPILNQSIKFYSSKDNATDKSQEKEQPKSILNDDMLARAGFEDVDPKEETSNSEEQATKQTGRKRKRAQTSKDLQRERYANMFYLSALIFGVAGVGYMSRDWDSEKEQEEMDGKNVENGYTPKLMYERLSKRLGSLFTFFSEPAFENLLPPPPPEQYRRPLTLVVTLDDFLIHSNWDTQHGWRTGKRPGLDYFLGYLSQYYEIVVFSSNSQIYSDKTVNKLDPYHAYISYALFREACRYKDGKLIKDLSLLNRDLGKTVMIDVDEDSAALQPENSIIVKKWEGQPDEYLISLIPFLEYLATQPVKDVRPILNSYKDKSNIVAEFAERENKLREQWRKDHGGNNGKPNAGNFIAKLLGIPVPEPKMPLDIIREHGQLQYEHFQKYLQENAHKFLEEEQKLKDEFGKVTLNKLITEGAPNAEEIAKVQQQRALEEAQKQQEGHK
Protein: Uncharacterized protein (Q583G0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQASRSKATRSPHRNTSGTLSASAPASSFLETITNRVATKYGVSFFLIKLGEEKAVHGTELQETLIATGKRAVSEKNPNKVQEVEKLRQSAEAWSNSWIRSLDPLRSQSEQQFRVRPLLPAALLLLLADIGLVKASESLCLLGVLEPAAAVEQHCRRSVGTSATKKTTLQPIISLCINALEGIVDVTERLSQQAKAMYRHTSKKNAANQGMEMTSSDSQGAEDDENWAEKCWPRFFLLSPCVPYASLRDVVNRVAREEGVSTLATTCGAGEACEVLLVYDFRHLTFPGIGEHVPDHNPEIWGRVKYQQKQQECNNGVVTDGEVEVANGNGSSEECDELFFIAHTLEDYLRLGSSFSWVYGWQLCYASQGPPPRSLPWLKLFAPSALAAVVASNTIVKGSEPARNVGASAQVSDAAVRKTAARS
Protein: At4g16670 (Auxin canalization protein (DUF828)) (Q5HZ31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- ADP-ribosylation factor GTPase-activating protein AGD7
Sequence:
MEYDRTLNLIPYGLQGVREEEEIEEDDEESMTLSSVPENETSECSSPPATYPPIPPRPKTPREPMEFLCRSWSLSTSEISLALSSQKSDKQLNKNPNISQLADVTSLAPVAPPPPLQTGKLASAVHARRTGTIGKWFHHREFVGGKVSAVKKRDRVRVEKAHLHSAVSIASLATAIAAVTASGNQDGFAGSKMSSALASASELLASHCLELAELAGADHDRVVSAVRSAVDVRGPGDLLTLTAAAATALRGEAALRVRLPKEAKNSAAISPCERVLPETHSCSSELDRTSTTDELISAKGVEESTGELMQCTRNGVLRWKHVKVYINKKSQVIVEIKSKHVVGAFSMKSKGIVNDVCETVSGLQNGKDTENTEEELYFGIGTGKGLTKFKCKSKADKQTWVDSIRNLLHRVTAVEVDTSLETININDST
Protein: Fasciclin-like arabinogalactan protein 15 (Fasciclin-like arabinogalactan protein 17) (A9XTM0)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
- NAD
- NAD
- NADH dehydrogenase iron-sulfur protein 2
- Mitotic spindle checkpoint protein MAD2
- Mitotic spindle checkpoint protein MAD2
- Mitotic spindle checkpoint protein MAD2
- Mitotic spindle checkpoint protein MAD2
- Photosystem I iron-sulfur center
- NAD
Sequence:
MAFMFFNSLLLLLLLLLQISCSRFSLALQENSSATVRSGQINSNSVLVALLDSHYTELAELVEKALLLQTLEETVGKHNITIFAPKNEALERDLDPEFKRFLLEPGNLKSLQTLLLYHIVPARIDRHSWPKSTSALTHHFTLSNERVELSGDDSSGEKFIGSAKVISSNAVDRPDGVIHGIEQLLIPRSVQQDFNNRRSLRSISAVKPEGAPEVDPRTHRLKKPAPPVKPGAPPVLPIYDAMAPGPSLAPAPAPGPGGPHHHFNGMRQVKDFIQTLIQYGGYNEMADILVNLTSLATEMGRLVSEGYVLTVLAPNDEAMAKLTTDQLSEPGAPEQIIYYHIIPEYQTEESMYNAVRRFGKVSYDTLRLPHKVLAQEADGSVRFGHSDGSAYLFDPDIYTDGRISVQGIDGVLFPLEEKAKEEKKTIKVATVKPRRGKLLEAACRMLVAIGQDSRFTSCRL
Protein: Flocculation suppression protein (Protein SFL1) (P20134)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in cell surface assembly and regulation of the gene related to flocculation (asexual cell aggregation). Mutations in SFL1 causes constitutive cell aggregation.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Flocculation protein FLO1
- Ty transcription activator TEC1
- Flocculation protein FLO11
- RNA polymerase II holoenzyme cyclin-like subunit
- Mediator of RNA polymerase II transcription subunit 16
- cAMP-dependent protein kinase type 2
- Transcriptional regulator NRG1
- Mediator of RNA polymerase II transcription subunit 19
- Transcription activator MSS11
- General transcriptional corepressor CYC8
Sequence:
MSEEETVSAPAPASTPAPAGTDVGSGGAAAGIANAGAEGGDGAEDVKKHGSKMLVGPRPPQNAIFIHKLYQILEDESLHDLIWWTPSGLSFMIKPVERFSKALATYFKHTNITSFVRQLNIYGFHKVSHDHSSNDANSGDDANTNDDSNTHDDNSGNKNSSGDENTGGGVQEKEKSNPTKIWEFKHSSGIFKKGDIEGLKHIKRRASSRNNSSINSRKNSSNQNYDIDSGARVRPSSIQDPSTSSNSFGNFVPQIPGANNSIPEYFNNSHVTYENANHAPLESNNPEMQEQNRPPNFQDETLKHLKEINFDMVKIIESMQHFISLQHSFCSQSFTFKNVSKKKSENIVKDHQKQLQAFESDMLTFKQHVMSRAHRTIDSLCAVNAAATAASVAPAPAPTSTSAYAPKSQYEMMVPPGNQYVPQKSSSTTNIPSRFNTASVPPSQLFVQYQPQSQQHVTYAKQPAHVPNFINQPIPIQQLPPQYADTFSTPQMMHNPFASKNNNKPGNTKRTNSVLMDPLTPAASVGVQGPLNYPIMNINPSVRDYNKPVPQNMAPSPIYPINEPTTRLYSQPKMRSLGSTSSLPNDRRNSPLKLTPRSSLNEDSLYPKPRNSLKSSISGTSLSSSFTLVANNPAPIRYSQQGLLRSLNKAANCAPDSVTPLDSSVLTGPPPKNMDNLPAVSSNLINSPMNVEHSSSLSQAEPAPQIELPQPSLPTTSTTKNTGEADNSKRKGSGVYSLLNQEDSSTSSADPKTEDKAAPALKKVKM
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q58FB8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRRAEKPEGYRQMRPKTFPASNNSGNSQQMLQEIRESLRNLSPSSNASKPEQSSGKGPPDESRQQGRSTNPRNSHHHRALQEIRKSLQPFAHDSSSSGDNSSADSSKHTLQTQEPGFDEELMVNRINFQEAVREQIPSARPVNTAIKQAGPPQIQQPLLRRQSWKGSKESLAPQRHSALINDVLIYRPSSPGPQSDLSRPATFPQNLASASSGQRVNAPLSRQVRSITPPPSSWDSNPSTKRYSGNLDYLVPRISPVPQGPRGDGYINPQSQNQRGLRPVPVGRQPIIMQNSNSNKFNFPPSWPQNGSMQNEYMGMNSGARQPPPPPYSMHQTNRQSPTAQQMQSSALTAPPNGASLPQSMLVPNRNSHNLDMYNLGVIRPPVQQAQTPPGQDTSSSWTHSVPGRSNSFTSAPNNRRQCPNSQLSATTVTTVTQAPILQPVKSMRVQKPELHTAVAPAHPPWLQPPPPTAYQEPPTPPAPAAEVPSYQGPPPPYPKHLLQQQQPPPGYDSSPALKPCSKEGDAADNENDTDSTCSSERAEGSEEEKKQITTSPVPVRRHKRDEERKGESRLPMYSPQAFKFFMEQHVENILKNHQQRMRRKKQLESEMQRVGLSGDAQEQMRMMLSQKESNYIRLKRAKMDKCMFEKIKTLGIGAFGEVCLARKVDTGALYAMKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFQEDLAQFYIAELICAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHVRQDSMDFSMEWEDSANCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILYEMVVGQPPFLATTPLETQMKVIRWQTSLHIPLQAKLSPEATDLILKLCRGPDDRLGRNGADEIKAQPFFRTIDLSKDLRQQHQAPYIPKITHSTDTSNFDPVDPDKLWSEDADGNHNDTLTRWFKNGKHPEHAFYEFTFRRFFDDSGHPYSCPKPIESEEEDEDEDYVEEDEPSQRPMEQSRDLVYV
Protein: Gb|AAD30234.1 (Lipase (DUF620)) (Q9FG09)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g58070
- Protein ACTIVITY OF BC1 COMPLEX KINASE 1, chloroplastic
Sequence:
MQRLAPLMEEPIDEEDQEEERGGRKGSTRSKSWKKWIKTQLQFIVFPKKPDMKLLLSVMGCPLFPVPPLSKISLQQVSSSAQYIIQQFAAATGCKKLAGEIKNTFVTGKITMTMVSDINSSTAVSSASSVSHKGCFVMWQMLPEKWLIELVGGGHKVSAGSDGEITWRYTPWLGDHAAKGAIRPLRRALQGLDPLTISSVFSSAQFVGEKEINGKDCFILKLSTDQIDLSKRSDSTAEMIKHVAFGYFSQKSGLLICLEDSSLTRIQIPGTVPTYWETSMSSWMEDYRAIEGSEVVIAHSGKTDVLISRFGETLKGGISVTRMEEKWTIDDVAFDVPGLSVDCFIPPKEMKMDFHHQDAQKHLPNYNT
Protein: MEMO1 family protein MHO1 (Memo-homolog 1) (P47085)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in haploid invasive growth under conditions of nutrient insufficiency, suggesting that the function of the MEMO1 family in cell motility/invasion is conserved across species.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22412880}. Nucleus {ECO:0000269|PubMed:22412880}. Note=Is actively exported from the nucleus. {ECO:0000269|PubMed:22412880}.
Interaction partners:
- Large ribosomal subunit protein eL32
Sequence:
MSIRPATHAGSWYSNRAQELSQQLHTYLIKSTLKGPIHNARIIICPHAGYRYCGPTMAYSYASLDLNRNVKRIFILGPSHHIYFKNQILVSAFSELETPLGNLKVDTDLCKTLIQKEYPENGKKLFKPMDHDTDMAEHSLEMQLPMLVETLKWREISLDTVKVFPMMVSHNSVDVDRCIGNILSEYIKDPNNLFIVSSDFCHWGRRFQYTGYVGSKEELNDAIQEETEVEMLTARSKLSHHQVPIWQSIEIMDRYAMKTLSDTPNGERYDAWKQYLEITGNTICGEKPISVILSALSKIRDAGPSGIKFQWPNYSQSSHVTSIDDSSVSYASGYVTIG
Protein: Complement component 1, q subcomponent, A chain (F1QFM5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- Complement component 1, q subcomponent, C chain.
- Complement component 1, q subcomponent, B chain.
- Plasma protease C1 inhibitor isoform X1, member 1)
- Complement component 1, r subcomponent
- C3/C5 convertase
- Mannan-binding lectin serine peptidase 2
Sequence:
MQPSAFFAFLWAGALLPFSFCQDECVKHGRNGADGPNGRDGLPGPKGEKGEPALQVKLSSIALEELKGDMGVRGPPGEPGLEGLMGAIGPRGPLGPAGPRGSSVGADGAKASEKPAFSVLRNETSQAQYKQPVTFNDKLSDANDDFQIKTGYFTCKVPGVYYFVFHASSEGRLCLRLKSTSAPPVSLSFCDFNSKSVSLVVSGGAVLTLLKGDKVWIEPFAGDGGVGQMPKRLYAVFNGFLIYRNAE
Protein: Quinone oxidoreductase 2 (EC 1.6.5.2) (P39315)
Organism: Escherichia coli (strain K12)
Function: Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth.
Interaction partners:
- NADH-quinone oxidoreductase subunit C/D
- Uncharacterized HTH-type transcriptional regulator YtfH
- NAD
- Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
- NADH-quinone oxidoreductase subunit B
- NADH-quinone oxidoreductase subunit G
- NADH-quinone oxidoreductase subunit F
- Acyl carrier protein
- NADH-quinone oxidoreductase subunit E
- Quinone oxidoreductase 1
Sequence:
MIAITGATGQLGHYVIESLMKTVPASQIVAIVRNPAKAQALAAQGITVRQADYGDEAALTSALQGVEKLLLISSSEVGQRAPQHRNVINAAKAAGVKFIAYTSLLHADTSPLGLADEHIETEKMLADSGIVYTLLRNGWYSENYLASAPAALEHGVFIGAAGDGKIASATRADYAAAAARVISEAGHEGKVYELAGDSAWTLTQLAAELTKQSGKQVTYQNLSEADFAAALKSVGLPDGLADMLADSDVGASKGGLFDDSKTLSKLIGHPTTTLAESVSHLFNVNN
Protein: Sarcosine dehydrogenase, mitochondrial (SarDH) (EC 1.5.8.3) (Q64380)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:9839943}.
Interaction partners:
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase
- Pipecolic acid and sarcosine oxidase
- Glycine N-methyltransferase
- Glycine N-methyltransferase
- D-amino-acid oxidase
- Threonine aldolase 1
- Alanine--glyoxylate aminotransferase
- 5-aminolevulinate synthase, non-specific, mitochondrial
- Glycine cleavage system P protein
Sequence:
MASLSRVLRVAATCPRGRSARNLGLQPLAREARPTTEKSVPYQCTLKEEAQGASVVPQGPSQPLPSTANVVVIGGGSLGCQTLYHLAKLGVGGVVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRQVVSHDLEEETGLHTGWIQNGGLFIASNQQRLDEYKRLMSLGKAYGIESHVLSPAETKDLYPLMNVDDLYGTLYVPRDGTMDPAGTCTTLTRAAVARGAQVIENCAVTGIRVRTDDFGVRRVTAVETQHGSIQTPCVVNCAGVWASSVGRMAGVKVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYEANPIFWDEVSDKFAFGLFDLDWDVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIVHGRPEKDMYSYDIRRFHHSLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERQGWERPGWFNPQETAQVLDYDYYGAYGHQAHKDYAYSRLLGDEYTFDFPPHHCVIQKECLACRTAAAVFNMSYFGKFYLLGADARKAPDWLFSADVNRPPGSTVYTCMLNQRGGTESDLTVSCLAPGAQASPLAPAFEGDGYYLAVGGAVAQHNWSHINTVLQDQEFRCQLMDCSEDLGMLSIQGPASRDILQDVLDADLSNEAFPFSTHQLVRAAGHLVRAIRLSFVGELGWELHVPQASCLPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRSDDSPLEAGLAFTCKLKTSVPFLGREALEKQRATGLRRRLVCLTVEEEVPMFGLEAIWRNGQVVGHVRRADFGFTVNKTIAYGYIRDPSGGPVSLDFVKNGDYALERMGVTYAAQVHLKSPFDPDNKRVKGIY
Protein: Outward-rectifier potassium channel TOK1 (Two-domain outward rectifier K(+) channel YORK) (P40310)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Outwardly rectifying potassium channel.
Subcellular location: Cell membrane {ECO:0000305|PubMed:22329368}; Multi-pass membrane protein.
Interaction partners:
- High-affinity potassium transport protein
- Low-affinity potassium transport protein
- Na
- Sodium/potassium exporting P-type ATPase 1
- K
- Serine/threonine-protein kinase YPK1
- Endosomal/prevacuolar sodium/hydrogen exchanger
- Low affinity vacuolar monovalent cation/H
Sequence:
MTRFMNSFAKQTLGYGNMATVEQESSAQAVDSHSNNTPKQAKGVLAEELKDALRFRDERVSIINAEPSSTLFVFWFVVSCYFPVITACLGPVANTISIACVVEKWRSLKNNSVVTNPRSNDTDVLMNQVKTVFDPPGIFAVNIISLVLGFTSNIILMLHFSKKLTYLKSQLINITGWTIAGGMLLVDVIVCSLNDMPSIYSKTIGFWFACISSGLYLVCTIILTIHFIGYKLGKYPPTFNLLPNERSIMAYTVLLSLWLIWGAGMFSGLLHITYGNALYFCTVSLLTVGLGDILPKSVGAKIMVLIFSLSGVVLMGLIVFMTRSIIQKSSGPIFFFHRVEKGRSKSWKHYMDSSKNLSEREAFDLMKCIRQTASRKQHWFSLSVTIAIFMAFWLLGALVFKFAENWSYFNCIYFCFLCLLTIGYGDYAPRTGAGRAFFVIWALGAVPLMGAILSTVGDLLFDISTSLDIKIGESFNNKVKSIVFNGRQRALSFMVNTGEIFEESDTADGDLEENTTSSQSSQISEFNDNNSEENDSGVTSPPASLQESFSSLSKASSPEGILPLEYVSSAEYALQDSGTCNLRNLQELLKAVKKLHRICLADKDYTLSFSDWSYIHKLHLRNITDIEEYTRGPEFWISPDTPLKFPLNEPHFAFMMLFKNIEELVGNLVEDEELYKVISKRKFLGEHRKTL
Protein: Decaprenyl-phosphate phosphoribosyltransferase (EC 2.4.2.45) (5-phospho-alpha-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase) (DPPR synthase) (P9WFR5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (pRpp) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR). The enzyme favors polyprenyl phosphate with 50-60 carbon atoms uses C-75 polyprenyl phosphate less efficiently than C-50 or C-60.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15878857, ECO:0000269|PubMed:18310020, ECO:0000269|PubMed:38491273}; Multi-pass membrane protein {ECO:0000269|PubMed:38491273, ECO:0000305|PubMed:18310020}.
Interaction partners:
- Decaprenylphosphoryl-5-phosphoribose phosphatase
- Terminal beta-
- Galactofuranosyltransferase GlfT2
- Decaprenylphosphoryl-beta-D-ribose oxidase
- Decaprenylphosphoryl-2-keto-beta-D-erythro-pentose reductase
- UDP-galactopyranose mutase
- Probable arabinosyltransferase C
- Ribose-phosphate pyrophosphokinase
- Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
- Probable arabinosyltransferase B
Sequence:
MSEDVVTQPPANLVAGVVKAIRPRQWVKNVLVLAAPLAALGGGVRYDYVEVLSKVSMAFVVFSLAASAVYLVNDVRDVEADREHPTKRFRPIAAGVVPEWLAYTVAVVLGVTSLAGAWMLTPNLALVMVVYLAMQLAYCFGLKHQAVVEICVVSSAYLIRAIAGGVATKIPLSKWFLLIMAFGSLFMVAGKRYAELHLAERTGAAIRKSLESYTSTYLRFVWTLSATAVVLCYGLWAFERDGYSGSWFAVSMIPFTIAILRYAVDVDGGLAGEPEDIALRDRVLQLLALAWIATVGAAVAFG
Protein: Alpha adducin (Q54T47)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Methylthioribose-1-phosphate isomerase
- Triosephosphate isomerase
- Enolase-phosphatase E1
- Transketolase
- Fructose-1,6-bisphosphatase
- Acireductone dioxygenase-requiring))
- ATP-dependent 6-phosphofructokinase
- Villin headpiece domain-containing protein
Sequence:
MISNNKFTSSDDLSLVNKTKYSDEEYLVRVKLAATYRMVAHLGWDELIYNHLTARVPGTDHMLLNAFGMRFDEVTATSLVTIDMDGKIIDAGSTDLGINKTGYVIHGAIHKARPDILATMHVHQEDTVAVACYKEGLLPISQNSFIIGDISYHNYEGISINAQEQERIVKSLGPVNKNLILRNHGIVSCGNSIEEAFFFLYQLVKTCEIQVKMLSMVGGDISKLDIPDKQIRDFSTRTAASFTKQGNGKKEWKSYYRIVEKLDDSFKN
Protein: Translocase of chloroplast 34, chloroplastic (AtToc34) (EC 3.6.5.-) (34 kDa chloroplast outer envelope protein) (GTP-binding protein OEP34) (Plastid protein import 3) (Q38906)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000269|PubMed:10998188}; Single-pass membrane protein {ECO:0000269|PubMed:10998188}. Note=May contain beta barrel transmembrane regions.
Interaction partners:
- Protein TOC75-3, chloroplastic
- Translocase of chloroplast 159, chloroplastic
- Protein TIC 40, chloroplastic
- Protein TOC75-4, chloroplastic
- Protein TIC110, chloroplastic
- Protein TIC 56, chloroplastic
- Translocon outer membrane complex 75-I
- Outer envelope protein 80, chloroplastic
- Protein TIC 22, chloroplastic
- Ankyrin repeat domain-containing protein 2A
Sequence:
MAALQTLREWIGIQQFPPATQSKLLEILGKYKEEDVSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVSTFQSEGLRPTLVSRTRSGFTLNIIDTPGLIEGGYVNDQAINIIKRFLLNMTIDVLLYVDRLDVYRVDDLDRQVVGAITDAFGKEIWKKSALVLTHAQFSPPDGLNYNHFVSKRSNALLKVIQTGAQLKKQDLQGFSIPVILVENSGRCHKNESDEKILPCGTSWIPNLFNKITEISFNGNKAIHVDKKLVEGPNPNERGKKLIPLMFAFQYLLVMKPLVRAIKSDVSRESKPAWELRDSGLASRRS
Protein: DNA replication complex GINS protein SLD5 (Q9U2W9)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR007764}.
Interaction partners:
- DNA replication complex GINS protein PSF3
- DNA replication licensing factor MCM7
- Probable DNA replication complex GINS protein PSF2
- Probable DNA replication complex GINS protein PSF1
- DNA replication licensing factor mcm-4
- Minichromosome loss protein Mcl1 middle region domain-containing protein
- DNA replication licensing factor MCM3
- DNA replication licensing factor mcm-5
- DNA replication licensing factor MCM2
- DNA replication licensing factor mcm-6
Sequence:
MAVTDSATTFLDFDDDEYDEMTTPEEVLRKMTATWQNELCAPCLLPTQMELVEILLDQIQGMEENIGKQTDKMQLRISVHRVELQRIGFITSDYVRCRLQKIESNPHDAIDQHKKRKEEGKSDLLSESEMKFAEEYALAESNLFQKTVLEFMPAALKKMPVPRGDHDDVMVYAKVTSDDVGNVAIPDWQDLNGEVILEMEPESCHLIPFESVHQLVEDGNIQLM
Protein: Large ribosomal subunit protein uL13m (54S ribosomal protein L23, mitochondrial) (O60118)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein mL40
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein bL17m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS14m
- Large ribosomal subunit protein bL36m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein mL41
Sequence:
MSTLNGQTALAYAKVWHHVSAKNVPLGRLASQIATTLMGKHKPIYHPAADCGDVVVVTDCSEIGISGRKLENHKYYSHSGQPGHLKEWTMEEMAAKRGHKDLLRRAVGGMLPRNKLWDRRMKRLYIYDGAEHPYKANIFRSYHNPVSSQIAKELFSK
Protein: PWWP domain-containing protein 2 (Q9SF36)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with PDP1, PDP3 and PDP6, interacts with MSI4/FVE and MSI5 to suppress FLC, MAF4 and MAF5 expression by regulating the function of the PRC2 complex and modulating H3K27me3 level, thereby promoting flowering.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- WD-40 repeat-containing protein MSI4
- Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1
- Protein IQ-DOMAIN 32
- WD-40 repeat-containing protein MSI5
- PWWP domain-containing protein 3
- PWWP domain-containing protein 1
- VIN3-like protein 2
- AMP deaminase
- PWWP domain-containing protein 5
- Probable galactinol--sucrose galactosyltransferase 5
Sequence:
MSTESERIESVSEANASSLEVGNDQMSEALAGQAQELKTIGDDKEGCGNFASAGDNGMEKVNGFTNLVKETESVNGELDLGTRTENVGGESNQSDKKVLVDSEEVMMVEKRGLLVEKEVEPDMVCSHGADLSDVKVSDGRLDSEDLVQDRKPDGLEKQGTKVEDLDVVCFMGLEPHESKDESILDDEIAHVAAKVKISDSDLVWAKVRSHPWWPGQVFDASAATDKAKKHFKKGSFLVTYFGDCTFAWNEASRIKPFRQHFSQMAKQSSLPDFIDAIDFALEEVSRRIEFGLACSCISEEVYQKIKTQNVINPGIREDSSSIHGGDKVSSAVFFEPANLVGYVKRLACSPSYDATDALQLVSQRAQLLAFNRWKGYTDLPEFMTLQGSVESAPKISPAEEQSSLVEVSDPEPTKSKQVYTKRRKTNLQTEQSSLVEVSDPDKGDCKHDGVFEYEETIVPKKKEKTLAEFIAEKRVSRHNGNTSHEKSGNVPHCEKKRKVVQSKVPKSTKKIKANLQTEDPGSPVSPKNDRKNNLSAGDKITPQKARKSFGIGASILKVANQMHCSTPTRLLPCSDSTSKKAAKSNGSGKSLQEKPKAEALSAREISPSTTLSSPHAASVTKTTSGKSNSVSLDHNLSGELDQVRKEAPSTNLVEDPMLESRDLKDSSKEQVVHEDKKEAANVADEKSIMDSNLTGEKISGLDLREQPSNKNCSGGSDSCKEDVSAE
Protein: Carbamoyl dehydratase HypE (EC 4.2.1.-) (Hydrogenase maturation factor HypE) (P31905)
Organism: Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha)
Function: Involved in the maturation of [NiFe] hydrogenases. Along with HypF, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypE catalyzes the ATP-dependent dehydration of the carboxamido group attached to its C-terminal cysteine to a cyano group.
Interaction partners:
Sequence:
MSGTVKLGYQRPLNIKSGRIDMGHGAGGRAAAQLIQELFVAAFDNEWLRQGNDQAAFAMPAGARMVMATDAHVVSPLFFPGGDIGSLSVHGTINDVAMAGAKPLYLAASFILEEGFPLADLKRIVESMAGAAREAGVPIVTGDTKVVEQGKGDGVFITTTGVGVVPAGILIDGAGARPGDAILLSGTMGEHGVAILSKRESLEFDTEIRSDSAALHDLVAQMLAVVPGVRVLRDPTRGGLATTLNEISSQSGVGMVLDEAAIPVLPQVDAACELLGLDPLYVANEGKLVAICAAADADALLAAMRGHPLGREARRIGEVIEDGRHFVQMRTKFGGMRVVDWLSGEQLPRIC