wanglab/gogpt-training-data huggingface dataset:
Protein: Receptor-like protein kinase HAIKU2 (EC 2.7.11.1) (Q9LJM4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates the seed size by negatively regulating the cellularization of syncytial endosperm.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable WRKY transcription factor 10
- Protein HAIKU1
- Phosphate transporter PHO1 homolog 4
- PHD finger protein At2g01810
- WRKY transcription factor 44
- Agamous-like MADS-box protein AGL62
- Auxin response factor 2
- F22C12.10
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
Sequence:
MLRLLFIVRLLFLMPLASSRSNHSEEVENLLKLKSTFGETKSDDVFKTWTHRNSACEFAGIVCNSDGNVVEINLGSRSLINRDDDGRFTDLPFDSICDLKLLEKLVLGNNSLRGQIGTNLGKCNRLRYLDLGINNFSGEFPAIDSLQLLEFLSLNASGISGIFPWSSLKDLKRLSFLSVGDNRFGSHPFPREILNLTALQWVYLSNSSITGKIPEGIKNLVRLQNLELSDNQISGEIPKEIVQLKNLRQLEIYSNDLTGKLPLGFRNLTNLRNFDASNNSLEGDLSELRFLKNLVSLGMFENRLTGEIPKEFGDFKSLAALSLYRNQLTGKLPRRLGSWTAFKYIDVSENFLEGQIPPYMCKKGVMTHLLMLQNRFTGQFPESYAKCKTLIRLRVSNNSLSGMIPSGIWGLPNLQFLDLASNYFEGNLTGDIGNAKSLGSLDLSNNRFSGSLPFQISGANSLVSVNLRMNKFSGIVPESFGKLKELSSLILDQNNLSGAIPKSLGLCTSLVDLNFAGNSLSEEIPESLGSLKLLNSLNLSGNKLSGMIPVGLSALKLSLLDLSNNQLTGSVPESLVSGSFEGNSGLCSSKIRYLRPCPLGKPHSQGKRKHLSKVDMCFIVAAILALFFLFSYVIFKIRRDKLNKTVQKKNDWQVSSFRLLNFNEMEIIDEIKSENIIGRGGQGNVYKVSLRSGETLAVKHIWCPESSHESFRSSTAMLSDGNNRSNNGEFEAEVATLSNIKHINVVKLFCSITCEDSKLLVYEYMPNGSLWEQLHERRGEQEIGWRVRQALALGAAKGLEYLHHGLDRPVIHRDVKSSNILLDEEWRPRIADFGLAKIIQADSVQRDFSAPLVKGTLGYIAPEYAYTTKVNEKSDVYSFGVVLMELVTGKKPLETDFGENNDIVMWVWSVSKETNREMMMKLIDTSIEDEYKEDALKVLTIALLCTDKSPQARPFMKSVVSMLEKIEPSYNKNSGEASYGESANDEITKVV
Protein: Lipid A 4'-phosphatase (EC 3.1.-.-) (B2RI48)
Organism: Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Function: Removes the 4'-phosphate group from lipid A species. Absence of phosphate groups in lipid A renders the bacteria resistant to host-derived cationic antimicrobial peptides (CAMP) and allows it to camouflage itself from the host innate immune response. Removal of the 4'-phosphate may be required to generate the substrate for deacylation of the pentaacyl lipid A to the tetraccylated lipid A species.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:A0Q4N6}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEYILEVERNLFLTLNGVQHPLLDGFFYLISAKWTWVIMSIAFLFFLFYKKPTKEALFIVGAVLLSVLICDQLSSSFFKPFFARFRPSHHPDFIDYVKTVYGYRGGKYGFISGHTTNYISLALFTSRIFRNKFYTWTIWSVVALVIYSRIYIGVHFITDIIPGIAVGLIVGHFVYKVYLYARSRWLGASCPAHPSAVYAGDSIRLWTLSLIGFVFAMLCMSRQLTEILQYYVFLLF
Protein: endothelin-converting enzyme 1 (EC 3.4.24.71) (D4A4U1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004250}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004194}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004194}. Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- Endothelin-1
- Insulin-degrading enzyme
- Endothelin-3
- Endothelin receptor type B
- Angiotensin-converting enzyme
- Endothelin-1 receptor
- Angiotensin-converting enzyme
Sequence:
MNVALQELGSGGSMVEYKRAKLQDEELPEVTVEGRAIQDSLEVGSQKRTRQLFGSHTQLELVLAGLILVLAALLLGCLVALWVQYHRDPVHSTCITEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPSGRSRWNTFNSLWDQNQAILKHLLENSTFNSSSEAERKTRSFYLSCLHLERIEKLGAKPLQDLIDKIGGWNITGPWDEDNFMEVLKAVAGTYRAAPFFTVYVGADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLAAYLDYMVELGMLLGGQPTSTRAQMQQVLELEIQLATITVPQDQRRDEEKIYHKMSISELQTLAPSMDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRAAFEETLENLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPRELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPWWQNESLTAFQNHTACMEEQYNQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW
Protein: Protein max (xMAX) (Myc-associated factor X) (Q07016)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity).
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MSDNDDIEVESDEDSSRFPYSADKRAHHNALERKRRDHIKDSFHGLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVQISNPKPPSNGAPEQKNVLQLLSPSKVRALEKAKSSSQLQSNYSSSESETEEPQSRKKLRMDAS
Protein: Uncharacterized ABC transporter ATP-binding protein YDR061W (Q12298)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961}.
Interaction partners:
- CCR4-associated factor 16
- Translation initiation factor RLI1
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein bL27m
Sequence:
MSTNKFVVRITNALFKSSLASNSPPVYPKRIRHFEILPNEKWVIWGPGKGKFLDVLNNKYICEPPLSLRFGFLKESSNILPRIEQVAFKGVMPTAHLSARYEYFKDDYDQTCKQFIFDKASGSNAVSYKVETNNRQINMELYNALVENLNLSSLQDRWVMGLSNGQMRRARLARSILKEPDLLLIDDPFLGLDPAAIATISQFLAKYDSIEVSGGCPIVIGLRYQDTIPAWCTHICCVDEKNGILFEGPIEKLQSKMDETRSRALKELEQLKKASNSKEDISINDLICIHPMYGKKEHEIIKMPHLIELDGLSVSYKGEAVLENLHWKVQPGSKWHIRGDNGSGKSTLLSLLTAEHPQSWNSRVIDNGVPRRTGKTNYFDLNSKIGMSSPELHAIFLKNAGGRLNIRESVATGYHEASSNNYLPIWKRLDKNSQEIVNMYLKYFGLDKDADSVLFEQLSVSDQKLVLFVRSLIKMPQILILDEAFSGMEVEPMMRCHEFLEEWPGTVLVVAHVAEETPKCAHYLRLISPGEYEIGDMEN
Protein: Galactose-3-O-sulfotransferase 2 (Gal3ST-2) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 2) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2) (Q6XQH0)
Organism: Mus musculus (Mouse)
Function: Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency (By similarity).
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MWGSQHRSFQVALWFLVLAVFLLVGFLHVDFRLLIPDKVQEPPVTNIMFLKTHKTASSTILNILYRFSESHNLSTALPEGSRVHLGYPWFFVTRYVEGLKQDAHLQHHFNIMCNHLRFNYPEVQKVMPRDTFYFSILRNPVFQLESSFIYYKDYAPAFQRAKSLDEFLADPWKYYNASVSLKNVYAKNNMWFDFGFDNNAPADMDYVRKRLAEVEQRFHLVLIADYFDESMVLLRRRLRWQLDDVVSFKLNVRSQSTVSHLTPESQERVQHWCALDWQLYQHFNRTFWTQLHAELSPRQLTEEVEQLRERQRELMALCLQDPEPKNLTHIDDQNLRPYQGGKANILGYNLRHGLDTTTLHICQRMAMPELQHMAHMYSLQFPDKTPKDIPFLKK
Protein: Protein mom-2 (Q10459)
Organism: Caenorhabditis elegans
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in cleavage axis determination. Binds to receptor tyrosine kinase cam-1. Together with wnt ligand lin-44, plays a role in controlling vulva precursor cell P7.p lineage orientation during vulva development, probably by acting as a ligand for tyrosine kinase receptor lin-18. May act redundantly with other Wnt ligands such as cwn-1 and cwn-2 to control seam cell polarity.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- CCCH-type zinc finger protein oma-2
- Uncharacterized protein C05C10.5
- CCCH-type zinc finger protein oma-1
- Pumilio domain-containing protein 5
- Pumilio domain-containing protein 7
- Protein mom-5
- Frizzled-4
- Frizzled-2
- Frizzled-4
- Protein-serine O-palmitoleoyltransferase porcupine
Sequence:
MHINTPVLLAIIYFLVFAPKSADAWWLLSKTDTSSANSGSSPILCKNVPGLTPQQKRMCHENPNIIKYLISGLRSALHTCEYTFQREAWNCTLTLPGVGTSPLQIASRESAYVYAISAAGVSHSLARACSKGLIDDCGCGETPQGSGSVAVSQASSRSSSDFVWAGCSDNVKFGNTFGRKFVDQYDRQHATEPRSQMNLHNNRVGRRLLVNAMNKECKCHGVSGSCVTKTCWKVMPKFDEFASRLHQKYQLAKLVTNNDQKLTVRSSPSAGSSGRSERFARNMDASSKQMRNELIYLDASPNYCAIDVKDRECGENCPNICCGRGWRTTREIVDEPCHCQFVWCCEVKCKTCKKLVERNYCL
Protein: Uncharacterized protein Rv2468c (P9WLA7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved protein
- Cytochrome bc1 complex Rieske iron-sulfur subunit
- Probable cytochrome c oxidase polypeptide 4
- Cytochrome c oxidase subunit 2
- Cytochrome bc1 complex cytochrome b subunit
- Phage shock protein A
- HNH nuclease domain-containing protein
- PspA protein
- Probable cytochrome c oxidase subunit 1
- Cytochrome bc1 complex cytochrome c subunit
Sequence:
MTHRSSRLEVGPVARGDVATIEHAELPPGWVLTTSGRISGVTEPGELSVHYPFPIADLVALDDALTYSSRACQVRFAIYLGDLGRDTAARAREILGKVPTPDNAVLLAVSPNQCAIEVVYGSQVRGRGAESAAPLGVAAASSAFEQGELVDGLISAIRVLSAGIAPG
Protein: Microtubule-associated protein 1 light chain 3 alpha (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (Microtubule-associated proteins 1A/1B light chain 3A) (MAP1A/MAP1B LC3 A) (MAP1A/MAP1B light chain 3 A) (Q6XVN8)
Organism: Rattus norvegicus (Rat)
Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.
Subcellular location: Endomembrane system {ECO:0000250|UniProtKB:Q9H492}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H492}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9H492}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H492}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q9H492}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91VR7}. Note=LC3-II binds to the autophagic membranes. {ECO:0000250|UniProtKB:Q9H492}.
Interaction partners:
- Sequestosome-1
- FUN14 domain-containing protein 1
- Ubiquitin-like modifier-activating enzyme ATG7
- Ubiquitin-like-conjugating enzyme ATG3
- Next to BRCA1 gene 1 protein
- FYVE and coiled-coil domain-containing protein 1
- BCL2 interacting protein 3
- Peptidyl-prolyl cis-trans isomerase FKBP8
- Autophagy protein 5
- Ubiquitin-like protein ATG12
Sequence:
MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFGF
Protein: HCG2036974 (Q8NDP9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEFQNMYIQLFGFSFFIVIIVRMLLLGLCVSARQPVMPRATLWGHLSPAWVLVPWTPRACGQAAPGRGHVASDHKSGAALAQALQLPAPPGFAALLVFSEQQQNSVHSDSKGGIGLDVLGTSQPSPTLYVNV
Protein: Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Q3UPF5)
Organism: Mus musculus (Mouse)
Function: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8K3Y6}. Nucleus {ECO:0000250|UniProtKB:Q8K3Y6}. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250|UniProtKB:Q8K3Y6}.
Interaction partners:
- Antiviral innate immune response receptor RIG-I
- Protein mono-ADP-ribosyltransferase PARP4
- E3 ubiquitin/ISG15 ligase TRIM25
- Poly [ADP-ribose] polymerase 2
- Protein mono-ADP-ribosyltransferase PARP3
Sequence:
MTDPEVFCFITKILCAHGGRMTLEELLGEISLPEAQLYELLKAAGPDRFVLLETGDQAGITRSVVATTRARVCRRKYCQRPCDSLHLCKLNLLGRCHYAQSQRNLCKYSHDVLSEQNFQVLKNHELSGLNQEELAVLLVQSDPFFMPEICKSYKGEGRKQICGQPQPCERLHICEHFTRGNCSYLNCLRSHNLMDRKVLAIMREHGLSSDVVQNIQDICNNKHTRRNPPSMRAPHPHRRGGAHRDRSKSRDRFHHNSLEVLSTVSPLGSGPPSPDVTGCKDPLEDVSADVTQKFKYLGTQDRAQLSSVSSKAAGVRGPSQMRASQEFLEDGDPDGLFSRNRSDSSTSRTSAAGFPLVAAQRNEAGAMKMGMPSGHHVEVKGKNEDIDRVPFLNSYIDGVTMEEATVSGILGKRATDNGLEEMILSSNHQKSVAKTQDPQTAGRITDSGQDTAFLHSKYEENPAWPGTSTHNGPNGFSQIMDETPNVSKSSPTGFGIKSAVTGGKEAVYSGVQSLRSHVLAMPGETTTPVQGSNRLPPSPLSSSTSHRVAASGSPGKSSTHASVSPASEPSRMMMMMSDPAEYSLCYIVNPVSPRMDDHGLKEICLDHLYRGCQQVNCNKNHFHLPYRWQLFILPTWMDFQDMEYIERAYCDPQIEIIVIEKHRINFKKMTCDSYPIRRLSTPSFVEKTLNSVFTTKWLWYWRNELNEYTQYGHESPSHTSSEINSAYLESFFHSCPRGVLQFHAGSQNYELSFQGMIQTNIASKTQRHVVRRPVFVSSKDVEQKRRGPDHQPVMPQADALTLFSSPQRNASTVSSNEYEFIELNNQDEEYAKISEQFKASMKQFKIVTIKRIWNQKLWDTFERKKQKMKNKTEMFLFHAVGRIHMDYICKNNFEWILHGNREIRYGKGLCWRRENCDSSHAHGFLEMPLASLGRTASLDSSGLQRK
Protein: Olfactory receptor 4F3/4F16/4F29 (Olfactory receptor OR1-1) (Q6IEY1)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
MDGENHSVVSEFLFLGLTHSWEIQLLLLVFSSVLYVASITGNILIVFSVTTDPHLHSPMYFLLASLSFIDLGACSVTSPKMIYDLFRKRKVISFGGCIAQIFFIHVVGGVEMVLLIAMAFDRYVALCKPLHYLTIMSPRMCLSFLAVAWTLGVSHSLFQLAFLVNLAFCGPNVLDSFYCDLPRLLRLACTDTYRLQFMVTVNSGFICVGTFFILLISYVFILFTVWKHSSGGSSKALSTLSAHSTVVLLFFGPPMFVYTRPHPNSQMDKFLAIFDAVLTPFLNPVVYTFRNKEMKAAIKRVCKQLVIYKRIS
Protein: Conserved protein (O05861)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Bifunctional oligoribonuclease and PAP phosphatase NrnA
- Uncharacterized oxidoreductase Rv0484c
- Formylglycine-generating enzyme
- Linear primary-alkylsulfatase
- Ribonuclease Z
- Conserved alanine valine rich protein
- Probable adenylyltransferase/sulfurtransferase MoeZ
- Conserved protein
- Probable conserved transmembrane protein
- Conserved protein
Sequence:
MGSTRLTGVNVEPPPEHVLVAFGLAGAQPILLGAGWEGGWRCGEVVLSMVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGAPEPRHDEVVSAAVRLHEATGKLERPRFLTQGPAAPWAEIDVFVAADRAGWEERPLQSVPPGVPTAPPAADPQRSIDLINQLAGLRKPTKSPNQLVHGDLYGTVLFAGTAPPGITDITPYWRPASWAAGVAVVDALSWGAADDGLIERWNALPEWPQMLLRALMFRLAVYALHPRSTAEAFPGLAHTAALVRLVL
Protein: Torn and diminished rhabdomeres, isoform D (Q9I7L6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSGSLLDVLCSGSGARLALGASVISYLIVYNEASAPSLLVGVVLATVYGAMAARCKTSLRSLQMPYVRATNKFDFSCLFLAIWLDALATVCACAALARTLSACLDAMTGGLARILILGRNAPANEPWPDVLGVSVVFLVTGMFMLGLEHSRAFSLILTLGMFGLNAILSAVGWWRGDMLAWSADSYFQPDGISSVFLGTALLTYSFPGDWPQQLRGGRFTATLITGLVSTSLLLTAICLSTVVHYRSQEDYVAVPLFNILDENGFHKLVPASACMLLLTSSAAFLELFPELYGIVVRLATSEWRILSKQISYESSESGNPVLAVFIAGSMCAMLAFACPLQHLSYTLAAGHMGGVFLRALYLLYIPYRPKYMAPSSESSLSYSRLSTAPFAKSSSYSSAATSSSSRLKRSLWKIGLPKHSNLKKPKTKPRNKQELEKEWLLLGEPTSPCPQREGRDVESTILSDGEPPPSDFEYPDKFDKSDSDTSTDIDAIVDEYREKIKVTTAGPLERSVRVPTVSSWRVTIFAIVVIGLGIALCIAGLMMHWAPAALTGGIGVLIVTIMMGFIPKYTGSVINVSPVICGMSLLMGVILFSGCAIHSWPGLLIWLMAGLILVIRCDKYCCNCFEHTTIMNAQLIPSVSGKSNMGSASGSASNLAGPSTSIRIPRPPKGMGVVGLPQRINEHRXQSESSEEEGEDLFHEDFNVRDFDEEDDEDCWTD
Protein: Meiotic drive suppressor wtf16 (Q9Y7N5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a suppressor component of the dual wtf meiotic drive system, and can suppress but not confer meiotic drive by compatible poisons (By similarity). Wtf meiotic drive systems promote unequal transmission of alleles from the parental zygote to progeny spores by encoding a poison and an antidote from the same locus; the poison is trans-acting and forms toxic aggregates in all spores within an ascus, wherease the antidote is spore-specific and targets aggregates for degradation by the vacuole (By similarity). Meiotic drive by wtf systems therefore lead to poisoning of all progeny that do not inherit the dual poison/antidote allele, or express a compatible antidote (By similarity).
Subcellular location: Spore membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- J-type co-chaperone jac1, mitochondrial
- Putative cell agglutination protein pfl5
- Probable ubiquitin carboxyl-terminal hydrolase 9
- Pyruvate kinase
Sequence:
MKNNYTSLKSPIDEGDESKTGHEIDLEKGLLPEYDSEEEGALPPYSDHARVSNSPNTHRENNPSRSTDNSSPFLIKLLISFTPIYVLNVLAICYLKYKDAFFKNYGAAEWTLFGFWCLVCTLALIFLTYFYETWTKAVKVTAVGLYNSRKKWVVIIWLLWVVICFVLFGCIKFGNLNLDKALICSTCSISAALLLFLLYVRLPFWTLKHMFSGLFQVLGVQSCVVIVTKGLMYLFDKHIDATGYEIEATSLFVIGNFFFFYEMECPGALKRMPKFIRNGIASFLEGIGNAIGRIGNAFRGANDNNNNIPLEETEAESEV
Protein: MH2 domain-containing protein (Q2L6Y5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDPHGENEGRLCLGALSNVHRTEASEKARIHIGRGVELTAHADGNISITSNCKIFVRSGYLDYTHGSEYSSKAHRFTPNESSFTVFDIRWAYMQMLRRSRSSNEAVRAQAAAVAGYAPMSVMPAIMPDSGVDRMRRDFCTIAISFVKAWGDVYQRKTIKETPCWIEVTLHRPLQILDQLLKNSSQFGSS
Protein: Large ribosomal subunit protein uL30A (60S ribosomal protein L7-A) (P17937)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P05737}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ribosome biogenesis protein erb1
- Ribosome biogenesis protein rlp24
- mRNA export factor elf1
- Ribosome biogenesis protein nsa2
- Large ribosomal subunit protein uL23A
- Ribosome assembly factor mrt4
- Elongation factor 3
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL8
- Pescadillo homolog
Sequence:
MAEDAPVVQQTMLEPEVLLKKRKVNERTRKERVEQAIAKKEAQKKNRKETFKRAETFINNYRQRERERIRLNRSAKNKGDIFVPDETKLLFVIRIAGVKNMPPKIRKVLRLLRLSRINNAVFVRNNKAVAQMLRIVEPYVMYGIPNLHSVRELIYKRGFGKINGQRIALSDNALIEEALGKYDVISIEDIIHEIYNVGSHFKEVTKFLWPFTLTPVKHSLMEKKVKHFNEGRKAGYCGEEINELIKKQV
Protein: V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) (Q9D659)
Organism: Mus musculus (Mouse)
Function: Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20042595, ECO:0000269|PubMed:21768399}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Immunoglobulin superfamily member 11
- B- and T-lymphocyte attenuator
Sequence:
MGVPAVPEASSPRWGTLLLAIFLAASRGLVAAFKVTTPYSLYVCPEGQNATLTCRILGPVSKGHDVTIYKTWYLSSRGEVQMCKEHRPIRNFTLQHLQHHGSHLKANASHDQPQKHGLELASDHHGNFSITLRNVTPRDSGLYCCLVIELKNHHPEQRFYGSMELQVQAGKGSGSTCMASNEQDSDSITAAALATGACIVGILCLPLILLLVYKQRQVASHRRAQELVRMDSNTQGIENPGFETTPPFQGMPEAKTRPPLSYVAQRQPSESGRYLLSDPSTPLSPPGPGDVFFPSLDPVPDSPNSEAI
Protein: RecQ-mediated genome instability protein 1 (Q10160)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Structure-specific DNA-binding protein with a preference for cruciform structures. Also binds single-stranded DNA (ssDNA). Functions together with top3 to maintain genome integrity. Essential for proper meiotic cell division. Required for normal S-phase progression and DNA damage response.
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
- DNA topoisomerase 3
- ATP-dependent DNA helicase hus2/rqh1
- DNA replication ATP-dependent helicase/nuclease dna2
- Crossover junction endonuclease mus81
- Exodeoxyribonuclease 1
- ATP-dependent DNA helicase srs2
- DNA repair and recombination protein rad22
- Structure-specific endonuclease subunit slx1
- DNA repair protein rhp54
- DNA repair protein rhp51
Sequence:
MNQTTTLSTELTELGVRVQNRWLQSLLDYLAKKHSTGANTTPQLVMQYLVASDIRESTTSEGAAPYIVSEQHNVRIENTMLLQIVRVREIGISIVNQLEYLNDLEELKKLKGQKVIRLVHDESGDEEQNDDDGLTEAQDAVQKGSELKKMCRLILEDSNGQRFWGLERKPIKGIQLSTKLGTKLLVKNVLVRRGVLMLDPNNTTILGGSIEEWDKDYFPKRLIEELKGELSKTKA
Protein: Rhamnosyl O-methyltransferase (EC 2.1.1.-) (P9WIM5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD).
Interaction partners:
- PGL/p-HBAD biosynthesis glycosyltransferase Rv2958c
- Chorismate pyruvate-lyase
- GDP-L-fucose synthase
Sequence:
MGLVWRSRTSLVGQLIGLVRLVASFAAQLFYRPSDAVAEEYHKWYYGNLVWTKTTYMGINCWKSVSDMWNYQEILSELQPSLVIEFGTRYGGSAVYFANIMRQIGQPFKVLTVDNSHKALDPRARREPDVLFVESSSTDPAIAEQIQRLKNEYPGKIFAILDSDHSMNHVLAEMKLLRPLLSAGDYLVVEDSNINGHPVLPGFGPGPYEAIEAYEDEFPNDYKHDAERENKFGWTSAPNGFLIRN
Protein: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 (O96824)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
- Ragulator complex protein LAMTOR4 homolog
- Ragulator complex protein LAMTOR2 homolog
- Ragulator complex protein LAMTOR1
- Ragulator complex protein LAMTOR3 homolog
- GH04846p
- GH16429p
- Raptor, isoform B
- RE13835p
- Serine/threonine-protein kinase mTor
- GEO02534p1
Sequence:
MEQQLEKVLAEIAARQDTVGALLANRQGLCLGTKGDIDPNVSGIGMAISEQVAKLELNATAPATICLYSGNKRCVIQKDGEITGVIFKQPTGTSATAPSN
Protein: Pleckstrin domain-containing protein (Q54DW4)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MSRQIIFGIDLETIVTTQNQAAFISEVPKIVAQVIEWLDKFNAVNEEGIFRIPGNGVTIQEIKKSFDEGKGDLSKFNSSDIHSVAGVLKLYLRELPEPLFIWRYYSTFIKVIKNPDHLQRALHLRMLCYGLPKVNRDLVLSLMVFLNKISLNNRVNKMTSQNLATVFAPNILRPQKETLNQIMEDSAYVTSIIKTFVDEISFISKQSNHLSTSIDDIPSVSLPKSPSNYSVSSGGDSVSSLEEENLYATALYPYQASGQWHLPFKKDDKIVLLDIKSEEGWLKGELNGKIGYFPASYVEIIAIPPPVGTPQTLIPIPDFDSQQDLSTISSPILSSSTTSSSSSISTDSNLSSNNNNNNNNNNNNSTPILSSTSTTTTTTTTINNNNSNNTFQPISVSKSSSFSKSTISTNPSSKSSSNLLISNPPPVNKSTTTATSSSPDITKIIGAPPNKLTAPPPLVPPTFTAPPPLSAPPPLISPTSTLTSSSNTAFTAPPTTSTTNGGNSPSGSSLNIGGGGNNSRAGSFLQSNIGGGGSNTTSPDLSKIMSTTPKLSFSSGIMMPPSLGIPPPLLPSKFLGNLSSSSGNISPPISNSGGSRNGSFLDSPPPPPPLSIPPTPLQNIPPPLQNIPPPITTPTKTTTTTVRSNSPSLLPIDLANLPPPPFSPCSPEPPQIQNLNINTDLPPPPPPPNFIDNATTTTTTTDDEDSNNSNLNIYNLPPPIFNIGDIDFKNFENGELAPMDISFIPLPPPLPAVVPANIPPPPPPPPKKLDRKDSYIHKKKMSQEKENEIKKKRRERAEETLTTEQTYVKQLTVVYDNFIEPYKKTQKCHGLTGEEFMDIFNCLEVILSSHKTNLLKPIEDRMLVWDSKPQMGDIFLNNTSFIKLYKHYVNNYDKSIRTLKQCKEKYDGFKTYMASLDYSEKLSNLSLESFLILPIQRLPRYVMLLQDLLKYTANDHEDFNQLCEALSTIKDLTESINTKKSEEDNNTKILQVQEQIKDMPPNTMTLRKRFVTEGALTLKKDKYYVFLFTDAMILTKPGKEKKKFKNIINLSTASLNTTDEQNVLKVISQEGTFKFSTDNPAEREHWVKDIKDAIDTARQDLIQTAFGESTTLNEGSKGFNKIQDEKNMLKKQKLAQELALSEEEYVDSLTYIYNVFLQPIKKSIDTPNQLVSYQENLEISSNFETLFSCHKTFLIALKERIAEWDSKPLMSDIFMEKAGFLKLYNYYVQNHTRSLQVLEHCIEKYPLFAIHLKRIESDQNTELKVLLAQPLRRVSKYYLVLREILQYTRPKHDDYDALNRVVANLKDQTDKFNANSTSQMSAEAGSKSPSQKYKTIKLTKNSKQPSQFFV
Protein: Prolyl endopeptidase (EC 3.4.21.-) (F4I0I5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAVTYLLRRYKPATISSVLSFSTKCFVGRTSSLSVPTEAPPVPKKIPFAISSHGITRQDPFHWMKNTDDTDFVDFLKRENSYSQAFMADTETLRRDLFSEMKTRIPEEIFTPPERWGQWLYRQYIPKGKEYPLLCRRLEKGKTNWLSGLFRGEEEEVVLDWNQIAEQFGYVHVGVCRVSPDHNYLAYTVDPEGDGITLFYTVTDENQRPHRVVVTNVESDGRDDAVVFTERDSSFCVDITTTKDGKFVTINSNSRTSSEVYIVNADKPMAGLQRTRERVPGVQCFLEHHNGFFYILTNSPSNAISEWSGEGYYLTRCLVEEIEASDWQTVFRPDDDVVIQDMDMFNDYLVLYLNKKGLPMLCSIDMPIKANTKHMDDLVPWYFPLPVDSCSVAPGSNHDFQSSIYRVVLSSPVIPDTIVDYDVSRRLFSIVQQEGGVVDNSDSSKPWYTADRSTENNGQLNDRTSEGEDGQLDSRMPKWEDLSDTYVCERQEVSSHDGVEVPLTILYSREAWKKSESPGMLIGYGAYGEVLDKSWCTNRLSMLDRGWVIAFADVRGGGSGEFSWHKSGTRSLKQNSIQDFIYSAKYLVEKGYVHRHHLAAVGYSAGAILPAAAMNMHPSLFQAVILKVPFVDVLNTLSDPNLPLTLLDHEEFGNPDNQTDFGSILSYSPYDKIRKDVCYPSMLVTTSFHDSRVGVWEGAKWVAKIRDSTCHDCSRAVILKTNMNGGHFGEGGRYAQCEETAFDYAFLLKVMGHHNNR