wanglab/gogpt-training-data huggingface dataset:
Protein: Forkhead box protein I3-A (A3KNJ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:A8MTJ6}.
Interaction partners:
Sequence:
MTSFVPQSLSPQFHSMGQESQEFSLYGDNFYSAQHVPSPQQTLPSAYDFGEYAGQTSNPYLWFNGPGLSPAPCLTTGPQHYGMAKQYVGASGIGGSEGAFSWFSLPSQEDLMKLVRPPYSYSALIAMAIHGAPNRRLTLSQIYQYVADNFPFYNKSKASWQNSIRHNLSLNDCFMKVPRDDSDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDSLAEEEGKGYSGSDSALSSPKNPSDSSERGNSPISTDQAPCLNSFLNQMGDVASGSREALLPSPLAVPLSQRSSPTGVYGSYSPNATMPQWETQIPQSSISSTPYKDGYSDSMLNPYSSQLYPVLGSSDLLYPREGSEV
Protein: Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 (EC 3.6.4.13) (Pre-mRNA-processing protein 2) (P20095)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing. Capable of hydrolyzing nucleoside triphosphates in the presence of single-stranded RNAs such as poly(U).
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:3536958}.
Interaction partners:
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor CLF1
- Pre-mRNA-splicing factor SPP2
- Pre-mRNA-splicing helicase BRR2
- Pre-mRNA-splicing factor CEF1
- Pre-mRNA-splicing factor 8
- Cold sensitive U2 snRNA suppressor 1
- Pre-mRNA-processing protein 45
- U2 snRNP component HSH155
Sequence:
MSSITSETGKRRVKRTYEVTRQNDNAVRIEPSSLGEEEDKEAKDKNSALQLKRSRYDPNKVFSNTNQGPEKNNLKGEQLGSQKKSSKYDEKITSNNELTTKKGLLGDSENETKYASSNSKFNVEVTHKIKNAKEIDKINRQRMWEEQQLRNAMAGQSDHPDDITLEGSDKYDYVFDTDAMIDYTNEEDDLLPEEKLQYEARLAQALETEEKRILTIQEARKLLPVHQYKDELLQEIKKNQVLIIMGETGSGKTTQLPQYLVEDGFTDQGKLQIAITQPRRVAATSVAARVADEMNVVLGKEVGYQIRFEDKTTPNKTVLKYMTDGMLLREFLTDSKLSKYSCIMIDEAHERTLATDILIGLLKDILPQRPTLKLLISSATMNAKKFSEFFDNCPIFNVPGRRYPVDIHYTLQPEANYIHAAITTIFQIHTTQSLPGDILVFLTGQEEIERTKTKLEEIMSKLGSRTKQMIITPIYANLPQEQQLKIFQPTPENCRKVVLATNIAETSLTIDGIRYVIDPGFVKENSYVPSTGMTQLLTVPCSRASVDQRAGRAGRVGPGKCFRIFTKWSYLHELELMPKPEITRTNLSNTVLLLLSLGVTDLIKFPLMDKPSIPTLRKSLENLYILGALNSKGTITRLGKMMCEFPCEPEFAKVLYTAATHEQCQGVLEECLTIVSMLHETPSLFIGQKRDAAASVLSEVESDHILYLEIFNQWRNSKFSRSWCQDHKIQFKTMLRVRNIRNQLFRCSEKVGLVEKNDQARMKIGNIAGYINARITRCFISGFPMNIVQLGPTGYQTMGRSSGGLNVSVHPTSILFVNHKEKAQRPSKYVLYQQLMLTSKEFIRDCLVIPKEEWLIDMVPQIFKDLIDDKTNRGRR
Protein: Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) (Q9UN37)
Organism: Homo sapiens (Human)
Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization, chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase. Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan. Critical for normal erythroblast cytokinesis and correct erythropoiesis.
Subcellular location: Late endosome membrane {ECO:0000250|UniProtKB:Q8VEJ9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VEJ9}. Midbody {ECO:0000269|PubMed:24814515}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:33186543}. Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody (PubMed:24814515). Localized in two distinct rings on either side of the Flemming body. {ECO:0000269|PubMed:24814515}.
Interaction partners:
- Charged multivesicular body protein 1b
- Charged multivesicular body protein 1a
- Charged multivesicular body protein 6
- Vacuolar protein sorting-associated protein VTA1 homolog
- Charged multivesicular body protein 2a
- Charged multivesicular body protein 5
- Charged multivesicular body protein 3
- IST1 homolog
- Charged multivesicular body protein 4c
- Vacuolar protein sorting-associated protein 4B
Sequence:
MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES
Protein: Zinc finger BED domain-containing protein 4 (Q80WQ9)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O75132}. Nucleus {ECO:0000269|PubMed:19369242}. Photoreceptor inner segment {ECO:0000250|UniProtKB:O75132}.
Interaction partners:
Sequence:
MEDKQETCPKGDSDFVSDKVNFKTEEDDDQTPCHSLEQVDFKSESEDMRQTDSGDEQADIRAASCACQPSGKFLAAESEDDYGSLFSQYSSTLYSVAMEAVTQSLLSSRHISSRKKSPAWKHFFISPRDSTKAICTYCMKEFSRGKNEKDLSTSCLMRHVRRAHPTKLIQENGSLSAGSSFSPPSLLLPPQPADVGDLSTVLSPVRLVQKMAPKIPSPDQIMEESVTVVSSEELSSDVSVTEKYSREEALAGSSPNLSMLHYDDASETMADRNLSLPKSTSGSRRRSAVWKHFYLSPLDSSKAVCVHCMNEFSRGKNGKDLGTSCLIRHMWRAHRSIVLQENGGNTGIPPLYPMPPTLLPALLPPEGDLNSASLSPGKQVKESPSASSSPERLPEDLSSHTNPGDVSREDVSMLSSSDDLGEASVVSSPEKQPADTVNPRFESGTVFQQNKKVMRRLKSEVWHHFSLAPMDSLKAVCRYCSCVISRGKKGDVGTSCLMRHLYRRHPEVVGNQKDFLGASLANSPYATLASAESSSKLTDLPAVVRKNHQGVFPTNSKKTSKLWNHFSICSADSTKVVCLHCGRTISRGKKPTNLGTSCLLRHLQRFHGHVLKNDVSEATLSRSPGIRRPLGIELSGPSSFRDSTEKFYDSHPVAKKITSLIAEMIALDLQPYSLVDNVGFNRLLEYLKPQYSLPSPSYFSRTAIPGMYDNVKQIIMSHLKEAESGVVHFTSGIWMSSQTREYLTLTAHWVTFASAVRPHCEDHHCSALLDVSQIDCDYSGNSIQKQLECWWEAWVTSIGLQIGITVTDNPSIGKMLSEGEHSSVQCFSHTVNLIVSEAIKSQRMVQNLLSIARKLCERVHRSPRAREKLAELQKEYELPQHQLIQDVPSKWSTSFHMLERLIEQKRAVNEVSIECNFRELISCDQWEVMQSVCHVLRPFDAASREMSAHMSTLSQVIPMIHILSRKVEMLFGETMGIDTMLKSLKEAMASRLSATLHDPRYIFATLLDPRYKASLFTEEEAEQYRQDLIRELEILNSTSEDTATSNGCDSGSPLKDTGTEESLWSLAPIKRDQREKLPEDMVLAYLEEEVLEHSCDPLTYWNLKRSSWPGLSTLAVRFLGCPPSTVPSEKLFSTPMDAGSFGQPRLMMEHFEKLIFLKVNLPLICFQY
Protein: ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) (Q91XU0)
Organism: Mus musculus (Mouse)
Function: Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS.
Subcellular location: Nucleus {ECO:0000269|PubMed:11301316}. Cytoplasm {ECO:0000250|UniProtKB:Q96S55}. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000269|PubMed:11301316}.
Interaction partners:
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- E3 ubiquitin-protein ligase RAD18
- F-box DNA helicase 1
- DNA annealing helicase and endonuclease ZRANB3
- ATM interactor
- DNA polymerase delta subunit 2
- DNA replication ATP-dependent helicase/nuclease DNA2
- Pseudouridine-5'-phosphatase
Sequence:
MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPARKGMGKRPAAAAAAGSASPRSWDEAEAQEEEEAGVDGDGDADVDGEDDPGHWDADAADASFGVSAGRAHPRALAAEEIRQMLEGKPLADKMRPDTLQDYIGQSRAVGQETLLRSLLEANEIPSLILWGPPGCGKTTLAHIIANNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNCSSEPSVFIEDKAVDTLAYLSDGDARTGLNGLQLAVLARLSSRKVFCKKSGQTYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKAMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALAQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRSHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQDYLPEELRGVDFFKQRRC
Protein: Dbj|BAA96220.1 (Tropomyosin) (Q9FMG6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEEQFGGSDERWKGSLENITEMASNLDSLQKLLLKKAVFVEEDTFSRASLVSEQARTIKVLEQRVQTLERELDAAITAAAHARSEKRQAESSQKAAESRAQDVTKELENTTKVFKLHMEELRGMQEQISKRDNEIKLLEAIIQTLGGKERLGKSDVNG
Protein: Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) (Q9HBX9)
Organism: Homo sapiens (Human)
Function: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16051677}; Multi-pass membrane protein {ECO:0000269|PubMed:16051677}.
Interaction partners:
- Prorelaxin H1
- Prorelaxin H2
- Relaxin-3
- Insulin-like 3
- Relaxin-3 receptor 1
- Relaxin-3 receptor 2
- Relaxin receptor 2
- Insulin-like peptide INSL5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
Protein: Protein pirA (Q6UK63)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in regulation of actin and microtubule organization.
Interaction partners:
- Protein BRICK1
- Nck-associated protein 1 homolog
- Protein SCAR
- Abl interactor homolog
- Eukaryotic translation initiation factor 4E
- Uncharacterized protein
- Uncharacterized protein
- Actin-related protein 2
- Rho-related protein racC
- Rho-related protein racD
Sequence:
MSVDPKQSKIADVFERCDVLESFPFHDDQSEIEEQSPSIGYDAYDKSLNYTDRGAYETQWSEETIGMEKMEEVLKQGDSFINMVYTYRSCSKALPTVKTAEQVNKTQIYEGNFEVLEPEIKKLKDFMYFQKDTIKLFCDHIKKLASTYDKKKETISASESFINYLVRILDLLAILDALKNMKACLNNDFSFFKRATGFLRKQMSGTEDQTQENHTLYLFLANQNSITSSLKLELHNIDKFDDILPMIVNQCADYLEQEKYILPSEKHCLLRVMPFVLFLIDENDSKHNINKNKNLNISRYAKIFKKNPVVPLYGDMQITLESLVKRSPHFDEKAWGTSTLDSKSALDYEIIHVLDQTRSLYNEYMARFANMVNEIRAAKARGPKEPLPLAESDIQAITLMGLRILSDWTSRVLQQSAWKYSKPNNDPTISATFDYERVVKFNYTKEERTALVQLIAMIKSLASLMMKSETLLQPILRKTIHQELQEFVQINLKETIKSFVKNNPKKKDNIKLEMSQLKNISVDWFSGFEPAEAVPNKKSKEVEEKVQIPARAVPPSPTQLELILTLVSSLMDKKKDFSSDQYRDFEAFSSKAFFYRYLLSLSSSIISITDLADLWYREFYLELNNRVQFPIETSLPWILTDHILESDDPSLIEHLFYPLGLYNDTAQRALLSLNQRFLYDEIEAELNLCFDQLLYKLSGKVYTHFKTQASSILLDKPYKTQLELAHFNGKLHTPKSRFDVLLRQKHITLLGRSIDLCGLLAQRQNNTIRQNLDYAISRFEACDLTSIVELETQIANIKLTHKLLSEYFDIDPFESIFNEINESTSLVSYHGRIVLHIIFELVADFAPNYTFNSITQRFIKAPYTFTEELKRDALPKTNPVFLFGNKYLNAAYANSIELYKNFIGVPHIQSILRIVGKKNLPLIVAEVLRNIEIKITNVLSPYVSELLQGMPASTKLPIYDYGTEGGYGYFQLKLKDIYIYPDLRPEVLQTFRELGNSLVFMNLLDQVITQTDSYNFAKAAPFLGITPETWKDLEPSTEDPTLQSPLYSQLQKLAQLLESRPEVAKSSQSLNDMVANAWRADKFYRPSEQNFSLFKSVLQRFSSILNIVRHDWSGAPPDNGVICVDSSTEFYRLWSALQFVICWPLSNENDKSFHELFGDGLMWAGCSLIHFLGQQYRFELFDFCYHILNVEEAAAVRSDKPALKNFFKNAQIIKDINNQIFSILNTYCPPPPPSNMILSPPATEQAEQFIVTTTVEEQSIQQQQQQQQQQQLQQSTSNSGSSLSLSAAGAPPPPPPPSTNGLPPPPPMAEYEMSSSIDDFAPPPPPPFGMPPPPPM
Protein: Entomoglyceroporin 4, isoform C (RE12132p) (Q8MLR2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSHEIRCCKVFKMKGSTLDKISAFLGELIGTGILVFLGCMGCVKTDLFPNNHLQIVLNFGFAVLIAIQCFGCVSGAHLNPAVTVAAYIYEMVTLRMAFAYFAAQMLGAFIGYGLLMVLLPSPTLTVGAGLCVTLPHTSVTTGQALGIEFVITSILVIVCCGVWDPRNSKFHDSVGIRFGLAIACLACAAGPFTGGSMNPARSFAPALWNKHFESNWIYWLAPLSSSAITAYAYKVVFRREVVEAEITSNEKLRQLEDVQLS
Protein: At4g36190 (Serine carboxypeptidase S28 family protein) (A4VCL8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- B3 domain-containing protein At4g34400
- Peroxidase 9
- Cytochrome P450, family 705, subfamily A, polypeptide 13
- Cytochrome P450 81F4
Sequence:
MSSELGFALLTTFTVLLSYLSFSNGLLQPRRISHGLSKSSKYLTRDELWFTQTLDHYSPSDHRKFRQRYYEYLDHLRVPDGPIFLMICGEGPCNGITNNYISVLAKKFDAGIVSLEHRYYGKSSPFKSLATKNLKYLSSKQALSDLATFRQYYQDSLNVKFNRSSNVENPWFFFGVSYSGALSAWFRLKFPHLTCGSLASSAVVRAVYEFPEFDQQIAESAGPECETALQETNKLLELGLKVNNRAVKALFNATELDVDADFLYLIADAGVMAIQYGNPDKLCVPLVEAQKNGGDLVEAYAKYVREFCMGVFGQSSKTYSRKHLLDTAVTLESADRLWWFQVCTEVAYFQVAPANDSIRSHQINTEYHLDLCKSLFGKGVYPEVDATNLYYGSDKIAATKIIFTNGSQDPWRHASKQTSSPDLPSYIMTCHNCGHGSDLRGCPQSAMVIEGDAQNCSSPDAVNKVRQHMIKHIDLWLSECRG
Protein: Protein kinase superfamily protein (F4J5Y7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- GDSL esterase/lipase At5g14450
- Glutaminyl-peptide cyclotransferase
- At5g19300
- At1g56580/F25P12_18
- Tubby-like protein 8
- Histone deacetylase complex subunit SAP18
- Putative U3 small nucleolar ribonucleoprotein
- RNA-binding KH domain-containing protein PEPPER
- Non-specific lipid-transfer protein 4
Sequence:
METDEAYQKKERAALVAIVVLACLALSSLFVAFSYYCYIRNKVSKRHRISKRFDCEEKGDCQKVQDVTENGLQIFTFKQLHSATGGFSKSNVVGNGGFGLVYRGVLNDGRKVAIKLMDHAGKQGEEEFKMEVELLSRLRSPYLLALLGYCSDNSHKLLVYEFMANGGLQEHLYLPNRSGSVPPRLDWETRMRIAVEAAKGLEYLHEQVSPPVIHRDFKSSNILLDRNFNAKVSDFGLAKVGSDKAGGHVSTRVLGTQGYVAPEYALTGHLTTKSDVYSYGVVLLELLTGRVPVDMKRATGEGVLVSWALPQLADRDKVVDIMDPTLEGQYSTKEVVQVAAIAAMCVQAEADYRPLMADVVQSLVPLVRNRRSASKLSGCSSSFSLARSPNSPGKASIGSQ
Protein: Cilia- and flagella-associated protein 298 (Protein kurly homolog) (Q5U3Z0)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24094744}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A0A1L8HCK2}. Note=Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization. {ECO:0000269|PubMed:24094744}.
Interaction partners:
- Cilia- and flagella-associated protein 20
- URB1 ribosome biogenesis homolog
- Transmembrane protein 17
Sequence:
MVVLHVKRGDESQFLLQAPGSTELEELTAQVTRVYNGRLKVHRLCTEIEELAEHGVFLPPNMQGLTDEQIEELKLKDEWGEKCVPSGGSVFTKDDIGRRNGHAPNEKMKQVLKKTVEEAKAMVSKKQVEAGVFVTMEMVKDALDQLRGAVMIVYPMGLPPYDPIRMEFENKEDLSGTQAALEVIQESEAQLWWAAKELRRTKKLSDYVGKNEKTKIIVKIQQRGQGAPAREPLISSEEHKQLMLFYHRRQEELKKLEENDDDSCLNSPWADNTALKRHFHGVKDIKWRPR
Protein: HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)] (P04233)
Organism: Homo sapiens (Human)
Function: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; SUBCELLULAR LOCATION: [Isoform p41]: Late endosome {ECO:0000250|UniProtKB:P04441}. Lysosome {ECO:0000250|UniProtKB:P04441}.
Interaction partners:
- CD44 antigen
- Macrophage migration inhibitory factor
- HLA class II histocompatibility antigen, DR alpha chain
- HLA class II histocompatibility antigen, DQ beta 1 chain
- Ubiquitin-like protein FUBI
- HLA class II histocompatibility antigen, DRB1 beta chain
- C-X-C chemokine receptor type 4
- HLA class II histocompatibility antigen, DM alpha chain
- HLA class II histocompatibility antigen DQ alpha chain
- C-X-C chemokine receptor type 2
Sequence:
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM
Protein: Homeobox-leucine zipper protein HAT22 (Homeodomain-leucine zipper protein HAT22) (HD-ZIP protein 22) (P46604)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:19245862}.
Interaction partners:
- Homeobox-leucine zipper protein HAT14
- At3g20340
- Homeobox-leucine zipper protein HAT2
- Adenine nucleotide alpha hydrolases-like superfamily protein
- Homeobox-leucine zipper protein HAT3
- Glutamine-dependent NAD
Sequence:
MGLDDSCNTGLVLGLGLSPTPNNYNHAIKKSSSTVDHRFIRLDPSLTLSLSGESYKIKTGAGAGDQICRQTSSHSGISSFSSGRVKREREISGGDGEEEAEETTERVVCSRVSDDHDDEEGVSARKKLRLTKQQSALLEDNFKLHSTLNPKQKQALARQLNLRPRQVEVWFQNRRARTKLKQTEVDCEFLKKCCETLTDENRRLQKELQDLKALKLSQPFYMHMPAATLTMCPSCERLGGGGVGGDTTAVDEETAKGAFSIVTKPRFYNPFTNPSAAC
Protein: Immunoglobulin heavy constant delta (A0A0A6YW14)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XNEKGPDMFLLSECKAPEENEKINLGCLVIGSQPLKISWEPKKSSIVEHVFPSEMRNGNYTMVLQVTVLASELNLNHTCTINKPKRKEKPFKFPESWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIEGAMAPSNLTVNILTTSTHPEMSSWLLCEVSGFFPENIHLMWLSVHSKMKSTNFVTANPTPQPGGTFQTWSVLRLPVALSSSLDTYTCVVEHEASKTKLNASKSLAISGIVNTIQHSCIMDEQSDSYMDLEEENGLWPTMCTFVALFLLTLLYSGFVTFIKVK
Protein: Achaete-scute homolog 1 (P19359)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q02067}.
Interaction partners:
- Transcription factor 12
- Cyclic AMP-responsive element-binding protein 1
- Myelin transcription factor 1-like protein
- Neurogenic differentiation factor 1
- DNA-binding protein inhibitor ID-4
- Homeobox protein DLX-2
- POU domain, class 3, transcription factor 2
- Oligodendrocyte transcription factor 1
- Paired box protein Pax-6
- Oligodendrocyte transcription factor 2
Sequence:
MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQAPQQQAPQLSPVADGQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
Protein: Probable inorganic phosphate transporter 1-7 (AtPht1;7) (H(+)/Pi cotransporter) (Q494P0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High-affinity transporter for external inorganic phosphate.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Inorganic phosphate transporter 2-1, chloroplastic
- Phosphate transporter PHO1 homolog 1
- SEC12-like protein 1
- Vesicle-associated protein 1-3
- Probable anion transporter 4, chloroplastic
- Mitochondrial phosphate carrier protein 1, mitochondrial
- Phosphate transporter PHO1
- Probable ubiquitin-conjugating enzyme E2 24
- Probable transcription factor At4g00610
- Probable anion transporter 3, chloroplastic
Sequence:
MAGDQLNVLNALDVAKTQWYHFTAIIIAGMGFFTDAYDLFCISLVTKLLGRIYYHVDGSEKPGTLPPNVSAAVNGVAFCGTLAGQLFFGWLGDKLGRKKVYGMTLMVMVLCSIASGLSFGSNPKTVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGFGILTGGIFAIIVSAAFEAKFPAPTYQIDALASTVPQADYVWRIILMVGALPAAMTYYSRSKMPETARYTALVAKDAKLAASNMSKVLQVEIEAEQQGTEDKSNSFGLFSKEFMKRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIPPAQTMNAIQEVFKIARAQTLIALCSTVPGYWFTVAFIDVIGRFAIQMMGFFFMTVFMFALAIPYDHWTHKENRIGFVAMYSLTFFFANFGPNATTFVVPAEIFPARFRSTCHGISAASGKLGAMVGAFGFLYLAQSPDKTKTEHGYPPGIGVKNSLIVLGVVNLLGMVFTLLVPESKGKSLEEMSGENEQNDESSSSSNNNSNNAVSTA
Protein: Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) (Q7TNY7)
Organism: Rattus norvegicus (Rat)
Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments (By similarity). Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8K3I4}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17827149}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:17827149}. Melanosome {ECO:0000250|UniProtKB:Q8K3I4}. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments. {ECO:0000250|UniProtKB:Q8K3I4}.
Interaction partners:
- Ras-related protein Rab-27A
- Unconventional myosin-Va
- Myosin VIIA
- Exocyst complex component 3
- Exocyst complex component 4
- Ras-related protein Rab-27B
- Exocyst complex component 2
- Exocyst complex component 8
- Septin-2
Sequence:
MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEDRLSEMKQRLAEENSKCSILSKHQKFVERCCMRCCSPFTFLVNARRRCGECKFSVCKSCCSYQKHEKLWVCCVCQQARLLRTQSLEWFYNNVKTRFKRFGSAKVLKNLYKKHRLESGACFDILGGGLYEPNLENEGSISGSDSTFYRQSEGHSMMDTLAVALQVAEEAIEEAISKAESQRDSLDKQNEASYLRDHRQELAEELAGTILQRIIRKQKDKADLHAEEEEPECTRPQSSGVKARGEGTAAPPGRHKARAALWRSQSAFSFTTEDTLKTSSAEAAPRQPKDRAQRLLEESALPSWRSMDGLDGKNLVPLLQSPDGNWMTLKDSSRQPPTRLLAKPKSRTFQALEVASSVASAYDELGSDSEEDFDYSEALSKLRPPSQGRLKQPQPQPAQAQSSGQGPLATSPSNPEAMCSDSETSSTSSSREAGCRAKLLWLQRKAPKNPSAEKTHLQGELDVNFNPQAAGGETSDSSDPEETLHTADRRARRWRRARVGPEESNRGLPSPSAYPPALHTAQVSDNVSETDISNEAQNSRSSTDSAEEKLRNRLYELAMKMSEKETSSGEDQESESKTEPKNQKGSLSSEENNQGVQEELKKKCSAVSLCNISTEVLKVINATEELIAESAGPWEIPPVSTDRDNGMFPLGTDQRSLDKQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSSTGETELADLEDQVAAAAAQVHHAELQISDIESRISALTIAGLNIAPCVRLTRRRDQKQRSQVQTIDTSRQQRRKLPAPPVKAEKIEASSVTPIKTFNRNFLLQGSSTNRPTASTSNTKDLMEPVLESAVMY