wanglab/gogpt-training-data huggingface dataset:
Protein: LDL receptor repeat-containing protein egg-2 (Egg sterile protein 2) (Q21629)
Organism: Caenorhabditis elegans
Function: Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-1, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-1 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maintain together to the unfertilized oocyte cortex several proteins including chs-1, kinase mbk-2 and pseudophosphatase egg-3, and possibly egg-4 and egg-5.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20971008}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q09967}. Endosome membrane {ECO:0000250|UniProtKB:Q09967}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q09967}. Note=Localizes to the cell membrane of developing oocytes (PubMed:20971008). Plasma membrane localization requires extracellular matrix protein cbd-1 (PubMed:20971008). After fertilization, localizes to endosomes in zygotes (By similarity). {ECO:0000250|UniProtKB:Q09967, ECO:0000269|PubMed:20971008}.
Interaction partners:
- RNA-binding protein pos-1
- PUM-HD domain-containing protein
- Chondroitin proteoglycan 3
- glutamine synthetase
- Inactive protein-tyrosine phosphatase egg-5
- Chitin-binding domain protein cbd-1
- CCCH-type zinc finger protein oma-2
- Protein tyrosine phosphatase-like protein egg-3
- Inactive protein-tyrosine phosphatase egg-4
- Chondroitin proteoglycan 1
Sequence:
MSQQAGNAQRGRFDEEPMSLGEKISHRMDQLKEIVSSSCPCAGKFPPVAIVLIVALIILGVIIAVPLVIFLSPSAQAMSSGTRDLSSHSIRHPKVWPKTEKVQDDDLSAIQMTSLLPPNVSTCSGFGFACTGSIDMIIPSSKRCDGLKDCSDGSDEENCKECQSIYSCRAHIEEESEKKDKTSVLPTLICLTAEKLCNGVENCPDGSDEASCRSKCSKDQFKCSGSDACLPISVKCDGVSDCENESDESNCNKCQKGAHKCGKNCIKASKVCDGIPDCDDGSDEHQCDCKTCSGSEKALCEDGTCIMRSQVCDGKHDCLDGIDEENCPGSCSNERFSSKLKLLTCDDGNQYSEVEACSGLVEACELNCPKCDPKHTFTCPAVGGIHNKCIKRSKVCDGIFDCEDGADEKKCTPVKECVVESSIQFTCDNKCLESSRRCDGVWDCEDKSDEKGCDKCPSRSFKCSADKKCLPFHTRCNGVAECSDGSDEHKCSCQECLGTHHDTYMCSESNRCLKRGEVCSPYSMCPNATYIDKAYCASLALKNSGLRP
Protein: HBS1-like protein (EC 3.6.5.-) (Q69ZS7)
Organism: Mus musculus (Mouse)
Function: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Y450}.
Interaction partners:
- Protein pelota homolog
- Exosome complex component RRP43
- Ubiquitin-like protein FUBI
- Exosome complex exonuclease RRP42
- Exosome complex component CSL4
- Exosome complex component RRP40
- Exosome complex component RRP45
- Exosome complex component RRP46
- Exosome complex component RRP4
- Exosome complex component RRP41
Sequence:
MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDNPEEEYGYEDLRESSNSLLNHQLSEIDQARLYSCLDHMREVLGDAVPDDILTEAILKHKFDVQKALSVVLEQDGVQPWKEKSERAVCAGQPSKGKSVISRSSQSESEIVPKVAKMTVSGKKQTMGFEVPGLTSEENGLSVRAPHKGPPGDDVSVASPNIPETGTPKSALPPPSLQTSEELGSTPTPVRKSGKLRQQIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNVNKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGLSGENLTARSQSSDLTTWYKGMCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCVTGKIEAGYIQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVNLTLVGMDIIKINVGCIFCGPKEPIKACTRFRARILVFNIEVPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYGGSTVAAGVVTEIKE
Protein: At1g48200 (Q6NPH1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MANKIAMFLSEAMNNNAVINTCLGVSFVVLGLRSDKQQKYVEALAEQKESLFKSNKAMKLTMWEWKQQLFAEAASAGNAAVVPLSTLKAIYGEVTTTTNQSGDTAKEDSKVSTPKIMI
Protein: Anthranilate synthase alpha subunit 2, chloroplastic (EC 4.1.3.27) (Anthranilate synthase component 1-2) (Anthranilate synthase component I-2) (P32069)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate (By similarity).
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Anthranilate synthase beta subunit 1, chloroplastic
- Anthranilate synthase beta subunit 2, chloroplastic
- anthranilate synthase
- Anthranilate phosphoribosyltransferase, chloroplastic
- anthranilate synthase
- indole-3-glycerol-phosphate synthase
- Indole-3-glycerol phosphate synthase, chloroplastic
- Anthranilate phosphoribosyltransferase
- Chorismate synthase, chloroplastic
- Anthranilate synthase alpha subunit 1, chloroplastic
Sequence:
MSAVSISAVKSDFFTVEAIAVTHHRTPHPPHFPSLRFPLSLKSPPATSLNLVAGSKLLHFSRRLPSIKCSYTPSLDLSEEQFTKFKKASEKGNLVPLFRCVFSDHLTPILAYRCLVKEDDRDAPSFLFESVEPGSQSSNIGRYSVVGAQPTIEIVAKGNVVTVMDHGASLRTEEEVDDPMMVPQKIMEEWNPQGIDELPEAFCGGWVGYFSYDTVRYVEKKKLPFSNAPEDDRSLPDVNLGLYDDVIVFDHVEKKAYVIHWVRIDKDRSVEENFREGMNRLESLTSRIQDQKPPKMPTGFIKLRTQLFGPKLEKSTMTSEAYKEAVVEAKEHILAGDIFQIVLSQRFERRTFADPFEIYRALRIVNPSPYMAYLQVRGCILVASSPEILLRSKNRKITNRPLAGTVRRGKTPKEDLMLEKELLSDEKQCAEHIMLVDLGRNDVGKVSKPGSVEVKKLKDIEWFSHVMHISSTVVGELLDHLTSWDALRAVLPVGTVSGAPKVKAMELIDELEVTRRGPYSGGFGGISFNGDMDIALALRTMVFPTNTRYDTLYSYKHPQRRREWIAHIQAGAGIVADSNPDDEHRECENKAAALARAIDLAESSFLEAPEFTTITPHINNI
Protein: Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) (Q86Y97)
Organism: Homo sapiens (Human)
Function: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
Subcellular location: Nucleus. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
Interaction partners:
- Histone H4
- Chromobox protein homolog 3
- Chromobox protein homolog 5
- Chromobox protein homolog 1
- Histone-lysine N-methyltransferase SUV39H1
- Histone-lysine N-methyltransferase SETDB1
- DNA
- N-lysine methyltransferase KMT5A
- Histone H4-like protein type G
- Serine/threonine-protein kinase BRSK1
Sequence:
MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPPLRRQQHLRSALETFLRQRDLEAAYRALTLGGWTARYFQSRGPRQEAALKTHVYRYLRAFLPESGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELREADEGLLRAGENDFSIMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPADGNAACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECHTCERKGEGAFRTRPREPALPPRPLDKYQLRETKRRLQQGLDSGSRQGLLGPRACVHPSPLRRDPFCAACQPLRLPACSARPDTSPLWLQWLPQPQPRVRPRKRRRPRPRRAPVLSTHHAARVSLHRWGGCGPHCRLRGEALVALGQPPHARWAPQQDWHWARRYGLPYVVRVDLRRLAPAPPATPAPAGTPGPILIPKQALAFAPFSPPKRLRLVVSHGSIDLDVGGEEL
Protein: Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Q503G7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLETPPMYPFEEIDYVDIEVEEVVGRGAFGVVCKAKWKGRDVAIKTIESESEKNAFIVELRQLSRVDHPNIVKLYGSCNNPVCLVMEYAEGGSLYNVLHGAEPLPHYTASHAMSWCLQCSQGVSYLHGMKPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHRGTRPPLIKNLPKAIESLMTRCWSKDPSQRPSMEEIVKIMSHLMGYFPGSEEPLKYPYQYSDEGQSNSATSTGSHLDYTCTSNKNDINMEHTNSPGSNDTIKFPYKPKGISGQSLSRGSSVESLPGRSHFQPSSDSKRMSVELSELEPRLPFASPATCEPHRRRSVQDLPAIGTDASQDSRNNSRSSSPSFRMITPDRTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYLKVQTEIALLKQRKEELIAELDQDEKDQQNACRLAQEQKKLIEENKSLSTYYQQCKKQLELIRAQQQKRQGTS
Protein: histidine kinase (EC 2.7.13.3) (Q6N5G2)
Organism: Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Interaction partners:
- Response regulator
- histidine kinase
- histidine kinase
- Blue-light-activated histidine kinase
- histidine kinase
- Response regulator transcription factor
- Blue-light-activated histidine kinase
- histidine kinase
- histidine kinase
- non-specific serine/threonine protein kinase
Sequence:
MSSRSDPGQPMASATDPSGRLALDLTECDREPIHIPGAIQPHGYLFVVSETDLRIASVSANVEDLLRQPPASLLNVPIAHYLTAASAARLTHALHGGDPAAINPIRLDVVTPDGERAFNGILHRHDSIVILELEPRDESRYTNEFFRSVRVAIRRLQTAADLPTACWIAASEVRRITGFDRIKVYQFAADWSGQVIAEDRDSGIPSLLDFHFPSSDIPAQSRALYTINPVRIIPDIGYRPSPLVPDINPRLGGPIDLSFSVLRSVSPTHLEYMVNMGMHAAMSISIVRDNRLWGMISCHNLTPRFVSYEVRQACELIAQVLTWQIGVLEEAEIVRHSVRMRAIQNRLLHELGDEQGLTAGLSRVSEEMLALMGASGFALCSFDGVAAFGRTPSDDEIQALASWLSHRESRGIFQTQQLSASFPEAEVYSDIASGLLAVPLGRASTTLMLWFRPEVAQTVTWGGDPHKPVQIGPRGRRLQTRASFEAWREEVRDRSRPWRSHEIVAAEEIRDLVVDVILGRAEELENANRELSRSNDELESFAYVAAHDLKEPLRHIEAFAGLLNDLLLPEARSRLSLMVNGIEASSRRLRALINDLAEYSRIGRQARPLQPVDLNQILTEVLSDLKPMLQDARAEVVSEPLPTVLCDGSQIRQLLQNLISNAVKYRDAERLPHVTIAATIDSPPPAAPAGANVRRARITIADNGIGFDEQYREQIFEPFQRLHGPDEYQGTGIGLAICRKIVHRHGGTISATSRVGEGSVFTFTLPLCDQDAAES
Protein: Non-specific lipid transfer protein GPI-anchored 6 (AtLTPG-6) (Protein LTP-GPI-ANCHORED 6) (Xylogen like protein 6) (AtXYLP6) (AtXYP12) (F4I082)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lipid transfer protein involved in seed and ovule maturation and development, probably by regulating the fatty acids homeostasis during suberin and sporopollenin biosynthesis or deposition. Contributes to pre-invasive defense against some non-host powdery mildew pathogens by preventing the penetration of the epidermal cell wall by the fungal agents (e.g. Blumeria graminis f. sp. hordei (Bgh)).
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.
Interaction partners:
- Non-specific lipid transfer protein GPI-anchored 1
- Non-specific lipid-transfer protein 6
- Amino acid transporter AVT1E
- At5g38980
- Ras-related protein RABB1a
- At5g48490
- Putative lipid-transfer protein DIR1
- Cytochrome P450 71B26
Sequence:
MEKSTRTLFITIVITSMLLGFGNSDLAQDREECTNQLIELSTCIPYVGGDAKAPTKDCCAGFGQVIRKSEKCVCILVRDKDDPQLGIKINATLAAHLPSACHITAPNITDCISILHLPRNSTLAKEFENLGRIEDNYNSTSPTQIHKDGTGGGKAEPVKSNGWKEKSWLGVELLIYLLVSLIFF
Protein: Junctional adhesion molecule-like (Adhesion molecule interacting with CXADR antigen 1) (Dendritic cell-specific protein CREA7-1) (Q86YT9)
Organism: Homo sapiens (Human)
Function: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12869515}; Single-pass type I membrane protein {ECO:0000269|PubMed:12869515}. Cell junction {ECO:0000269|PubMed:12869515}. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
Interaction partners:
- Coxsackievirus and adenovirus receptor
- Plexin-B2
- T-cell-specific surface glycoprotein CD28
Sequence:
MFCPLKLILLPVLLDYSLGLNDLNVSPPELTVHVGDSALMGCVFQSTEDKCIFKIDWTLSPGEHAKDEYVLYYYSNLSVPIGRFQNRVHLMGDILCNDGSLLLQDVQEADQGTYICEIRLKGESQVFKKAVVLHVLPEEPKELMVHVGGLIQMGCVFQSTEVKHVTKVEWIFSGRRAKEEIVFRYYHKLRMSVEYSQSWGHFQNRVNLVGDIFRNDGSIMLQGVRESDGGNYTCSIHLGNLVFKKTIVLHVSPEEPRTLVTPAALRPLVLGGNQLVIIVGIVCATILLLPVLILIVKKTCGNKSSVNSTVLVKNTKKTNPEIKEKPCHFERCEGEKHIYSPIIVREVIEEEEPSEKSEATYMTMHPVWPSLRSDRNNSLEKKSGGGMPKTQQAF
Protein: Mitochondrial import inner membrane translocase subunit TIM17 (Mitochondrial inner membrane protein MIM17) (Mitochondrial protein import protein 2) (P39515)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:27265872}; Multi-pass membrane protein.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM21
- Mitochondrial import inner membrane translocase subunit TIM23
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import inner membrane translocase subunit TIM44
- Import motor subunit, mitochondrial
- Presequence translocated-associated motor subunit PAM17
- Cytochrome c oxidase subunit 4, mitochondrial
- GrpE protein homolog
Sequence:
MSADHSRDPCPIVILNDFGGAFAMGAIGGVVWHGIKGFRNSPLGERGSGAMSAIKARAPVLGGNFGVWGGLFSTFDCAVKAVRKREDPWNAIIAGFFTGGALAVRGGWRHTRNSSITCACLLGVIEGVGLMFQRYAAWQAKPMAPPLPEAPSSQPLQA
Protein: Chondroadherin like (A0A287B8C4)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
PLSPRPQSVSLVLLLPLLLPLGPIWHAAAQRCPQTCICDNSRRHVACRHQNLTEVPNAIPELTQRLDLRGNVLRVIPPAAFQDLPYLTHLDLRHCQVELVAEGAFRGLGRLLLLNLASNRLSALPQEALDGLGSLRRLELEGNLLEELRPGTFGALGALATLNLAHNALVYLPPMAFQGLVRARWLQLSHNALSVLAPEALAGLPALRRLSLHHNELQSLPGLALSQARGLARLELGHNPFTYAGEEDGLALPGLRELRLEHGALQALDPRAFAHCPRLHTLDLRGNQLDALLPPQGPGQLRRLRCRGTRCGAAAARGRCSSGWRGRACARTARAGGRGACAARPWRPCGPGTCAAGSRGAGGRGGGGGAGAARPRAPAGAPKEEAGAARPCPRACVCVPESRHSGCEARGLRAVPRGFPNDTQLLDLRRNHFPLVPRAAFQGLGRLVSLHLQHCGITELEAGALAGLGSLIYLYLSDNGLSGLSATALEGAPRLGYLYLERNRFLQVPGAALGALPSLFSLHLQDNAVDRLAPGDLAAGRALRWLYLSGNRLTQVSPGALGPAQELEKLHLDRNQLPEVPTEALEGLPALLELQLSGNPLRALQEGAFRPVGRSLQHLFLNSSGLEQISPGAFSGLGPQLQSLYLQKNQLQALPPLPGLRQLELIDLSGNPFHCDCQLLPLHRWLTGLNLRVGATCATPPSARGQRVKAAAAVFDACPGGATRKAKRTPAPRRGAQRTPRKRRQHGADKVSQRAAAGWP
Protein: Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (F1QSA2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Cytochrome P450, family 17, subfamily A, polypeptide 1
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Cytochrome P450, family 11, subfamily C, polypeptide 1
- Cytochrome P450, family 17, subfamily A, polypeptide 2
- Aromatase
- Cholesterol side-chain cleavage enzyme
- 17-beta-hydroxysteroid dehydrogenase type 3
- Cholesterol 7-alpha-monooxygenase
- Cytochrome P450 7B1
- Hydroxysteroid
Sequence:
MALSGEVCVVTGACGFLGERLVRLLLKEEKLAEIRLLDRNIRSELIQSLDDCRGETKVSVFEGDIRNPELLRRACKGAALVFHTASLIDVIGAVEYSELYGVNVKATKLLLETCIQENVPSFIYTSSIEVAGPNPSGEPIINGNEDTPYSSRLKFSYSKTKKEAEEICLQANGDLLCNGGQLATCALRPMYIFGPGCRFTLGHMRDGIRNGNVLLRTSRREAKVNPVYVGNAALAHLQAGRGLRDPQKRAMMGGNFYYISDNTPHVSYSDFNYAVLSSLGFGIQERPILPFPLLYILSFFMELLHVVLRPFLTFTPPLNRQLLTMLNTPFSFSYQKAHRDFGYTPRYEWEEARKCTTDWFASVLPAEIRSINLK
Protein: Arginine transport ATP-binding protein ArtP (EC 7.4.2.1) (P0AAF6)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for energy coupling to the transport system.
Subcellular location: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Arginine ABC transporter permease protein ArtM
- Arginine ABC transporter permease protein ArtQ
- Putative ABC transporter arginine-binding protein 2
- ABC transporter arginine-binding protein 1
- L-cystine transport system permease protein TcyL
- Glutamine transport system permease protein GlnP
- Putrescine export system ATP-binding protein SapD
- Nickel import ATP-binding protein NikD
- Glutamate/aspartate import permease protein GltK
- Histidine/lysine/arginine/ornithine transport system permease protein HisM
Sequence:
MSIQLNGINCFYGAHQALFDITLDCPQGETLVLLGPSGAGKSSLLRVLNLLEMPRSGTLNIAGNHFDFTKTPSDKAIRDLRRNVGMVFQQYNLWPHLTVQQNLIEAPCRVLGLSKDQALARAEKLLERLRLKPYSDRYPLHLSGGQQQRVAIARALMMEPQVLLFDEPTAALDPEITAQIVSIIRELAETNITQVIVTHEVEVARKTASRVVYMENGHIVEQGDASCFTEPQTEAFKNYLSH
Protein: Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16) (Q92562)
Organism: Homo sapiens (Human)
Function: Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:17556371}. Note=Localization requires VAC14 and PIKFYVE. {ECO:0000269|PubMed:17556371}.
Interaction partners:
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Protein VAC14 homolog
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- Myotubularin
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Phosphatidylinositol-3-phosphate phosphatase MTMR1
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6
- Inositol polyphosphate-4-phosphatase type I A
- Phosphatidylinositol-3-phosphate phosphatase MTMR7
Sequence:
MPTAAAPIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVIKHLPLPYDEVICAVNLKKLIVKKFHKYEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTVGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREEEGSVSQRSTPVKMTDAGDSAKVTENVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQSQHKQDKNSQQPCSRCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDSSMYREYIRNRYL
Protein: Sac7p (A0A1D8PQG5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- GTP-binding protein RHO1
- Rga2p
- Bem2p
Sequence:
MESGMFSSIISSACNNKMSLRTTYPLDYTLSINNKNFFLYIFFFFPPPPFSILTIYIFFNCLLLLFFFSFALFHQTQFIMSSPNTGKSLFNTFTRNLKMVLSNESLPHVSDNENDSKSPMSTSPPQNIPIPQNPSLFHNPHQQPSTPSGNSYLNAVHSGISRVRSNSLNPSETSVRQQNVYFGVTLDNALVQGFAKISILGTDNNPDGLNYGKIPIVVAKCGVYLKKNGLTVEGIFRVGGSSKRLKELQIIFNTPPDFGKKLNWEGYTVHDAATILRRYLNALPEPLIPLEMYEVFRDPLRNRSRIINYMKYKAAVATSSISSPNPHTARANGNNNNNSYFPDMSQPLTEANIGKLNHDIAPRKNSESSSNVFSQSAPMPLSEEEVNTKSKKKSKSYKKLTNDIHEAIDEYKLLVNELPLASKQLLFYILDLLSMVQAQSKENLMNSRNLAAIFQPSILSHPNHDMDPVEYALSQAVVEFLIKYSYKLLPTTVSASPAVKSPVAARDESDVTSTSTTPLNEESHLSKENYPHRESVTSEPQDSLVAGFQHNVTGSIPFDSDIESDIGSDLDDLNFQQLKLNDGSPVKSSPPPAPQMPAAIVVSPPSSSSVHQSDK
Protein: Steroidogenic factor 1 (SF-1) (STF-1) (Adrenal 4-binding protein) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) (Steroid hydroxylase positive regulator) (P33242)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Subcellular location: Nucleus.
Interaction partners:
- Nuclear receptor subfamily 0 group B member 1
- Transcription factor SOX-9
- Sex-determining region Y protein
- Nuclear receptor subfamily 0 group B member 2
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Wilms tumor protein homolog
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Transcription factor GATA-4
- Catenin beta-1
Sequence:
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRSDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT