wanglab/gogpt-training-data huggingface dataset:
Protein: Subtilisin-like protease het-Q2 (EC 3.4.21.-) (Heterokaryon incompatibility protein Q2) (P0DW09)
Organism: Podospora anserina (Pleurage anserina)
Function: Serine protease involved in heterokaryon incompatibility, a process that ensures that during spontaneous vegetative cell fusion, only compatible cells from the same colony survive (non-self-recognition). In P.anserina, the het-q locus exists as 2 incompatible alleles, het-Q1 (AC B2AXJ5) and het-Q2 (this entry). Prevents cell fusion with strains containing the gasdermin-like protein het-Q1 by mediating proteolytic cleavage and maturation of het-Q1 during the allorecognition process, thereby triggering cell death.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSAISHHSLSHLNSTVSKRLMPTYSDPVVRIAVLDTGFDGSHPDFSHPRTAYFTGPFSDLPQPEKDEEPQLTRIKAYHDFCQPSPPGDRQGPPPQPHSMVDLAGHGTAIAGLILRLAPRAELVIGRVCHGVDSNELSAPDPSRVAAAIRWAITQKVHIINLSLGYRNQPLKELLPLRAALLEAQRSNILVFASTSNQGSHEPAAWPASDARFAIGVHSCNDMGSAPSGSSCKASENGYNFMAVGENLLVHRLAQKGGGFELVSGSSFATPVVVSVAALVLAFVWQEECKRERDEVGREVMLEDLGSLGGMGRVLMALGEKTAGSYWAVGMKLFWAGYREGDGRDPEKEEKEARRWAWGVLRGAVAY
Protein: Uncharacterized protein YfcO (P76498)
Organism: Escherichia coli (strain K12)
Function: Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
Interaction partners:
- Uncharacterized fimbrial-like protein YfcQ
- Uncharacterized fimbrial-like protein YfcP
- Uncharacterized fimbrial-like protein YfcR
- Probable fimbrial chaperone YfcS
- Uncharacterized fimbrial-like protein YadN
Sequence:
MKILRWLFALVMLIATTEAMAAGHSVDVYYGYNGDSRNIATFNLKIMMPSAVYVGEYKSSQWLMTGEILQNVSWSGPPPAPSVKLIGYHQNINKASCPGLPSGWNCGYYTFEVIVSAEIESYFSCPWLVIMNDSEASPGGVTYQGPDSHDTICPSVSVQPYDVSWNENYVSKSKLLTLQSTGGVVEKTLSTYLMKDGKLCDSTQMNETGGYCRWVAQMITFTASGCDKAEVSVTPNRHPITDKQLHDMVVRVDTSSMQPIDSTCRFQYILNEL
Protein: Protein mum3 (Muddled meiosis protein 3) homologue, putative (B9WDH2)
Organism: Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Interaction partners:
Sequence:
MSILGDDYSPIRQCEQFSLPIINFFSWFLVWRVPTIKILLHMLKSDENWELESKSLSFVFSRLLRSKFSEWVVLFPEVNIWTTNGATLQGQVSHKYFLPKFNHLLYPRFSAFFNIISILNQSKPHAYLNMYDITILYTRNGHGVASSQYKPPTLLDIFASAEPITVIVYVKIRSVSRIPTKRKKLEKYLEHLWIHKEKMISQLKAENDTHIQLRILQDDFSVAS
Protein: Bub1-related kinase (A1Z6I7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000256|ARBA:ARBA00004629}.
Interaction partners:
- Mitotic checkpoint protein BUB3
- Mitotic spindle assembly checkpoint protein MAD2A
- Cell division cycle protein 20 homolog
- Kinetochore protein NDC80
- Cell division cycle protein 27 homolog
- CENP-meta, isoform C
- separase
- CENP-ana, isoform A
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase polo
Sequence:
MDFDNAKENIQPLASGRNVSLLQASLSQDSTHGQELLAQRKQMEEEVRTYKGADPLGAWYTFICWIEQSYPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQKDKIEFYQQMYNNGIGTMLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDLKEAHHHFGYTVGQRMLYSTGEEANAVNQELNERRLALQSLHGRRQQISNSITVGSIRTGAAVKSGLPGVVQVEPSTTTSRRNVGRNVEVFNDENSEGNIPISNSETEVKSSLRSIIDSACSQENIKEPVAWNKANAKRHKHGKIFGSNASPDLGFDIHVDEQAMPPITNYERRLEQPFRFPTNFVAKNRPQEPWVTPVTIEDEPNASGLPCYNKCLLYPRPNIEFSPEEYRAYSFLKHRNPQHPFIHRNDDWWGTGRVIRGIRCYPNFARYSKPQDLDELDKFWKPPLVPGLQVVFDKIYNEVEQKEYQPEELLAAKWMEKRNVTVHGDFDMEETVCLPGNKMPRRKSFFPSSFRKSIMPRRVSSVQEEDEKKEDEATLIVKDIPSQVAPKIPESPCDQIDEPKIKIFEDSGSPRDNFAVPAVPVPKIEIYEDSEEPQPTPKTRPFYDGDETCSTQMFNMFIKSQAVSTPKGTQKQAPSRQFGTVLKELPLPEEAAHSVESPVETRSPTLRKQLSTILETSEHGTQSLATSGTTTKSTITSTSSPGSNAVSKLGSKIEENTPGQMRLQRVISAGVSAVLSEPEKPGGDNFLRRELWEPNAPSVPMLKSLRFQEDKTETIPRPLACFQEDKTETLPQMPIALPENSMDHGSLGAENCFSAPQLPTLEDESDLCGLFGKTPPKTNIFGSPKRNFDPTSQLFKSTQGDRRSFAVTGNKLEAAPSISNLQDSFMCDLSFVPETQPEAVAKSGAIQKFDIFLDDTQPKLTKSKPVALMVSSFDLDCTLPETQQVAIKEPGTQQENIGHSHMIASFMKDCTEIGSCPSQMPASVVKTNISSTSNKIKFSNDSMSESSRKAPVNENVGISKQPDEFFELNAATEMFATNISMIKNSTLLIPNAKVAEASELSIYYKTTPLTPKQSHRSWSQSDLETPPRENFVHPTSNGDQTVLNETLADANKNPFNVELISSLLESIDFSMYIEKLPHCQLVGHVKRLHPNTHLEVHNEKFEVSKMIGKGAYGSVYVGKHLKSGKKVALKQERPTNYWEFYICLEIHSRLTSEQMIPSYAHIDYALVGNNSSVYISEFSDYGSLIGVCNKVKSVTNRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICADPNEVSLQLIDFGVSIDMKLFPDNQTFNYVHHDDLFKCIEMRTGRPWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPSTIWMPKTNVPRYFQRTMWENIFRTLLNIRDCRTMPNLQQLRTQLKCALAEKEKYVAEAISKFNTILQK
Protein: Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver-type fatty acid-binding protein) (L-FABP) (Squalene- and sterol-carrier protein) (SCP) (Z-protein) (p14) (P02692)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (By similarity). Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Fatty acid-binding protein, heart
- Fatty acid-binding protein 5
- Fatty acid-binding protein, brain
- Apolipoprotein C-III
- Fatty acid-binding protein, adipocyte
- Peroxisome proliferator-activated receptor alpha
- Fatty acid-binding protein, intestinal
- Aspartate aminotransferase, mitochondrial
- Gastrotropin
- Apolipoprotein B-100
Sequence:
MNFSGKYQVQSQENFEPFMKAMGLPEDLIQKGKDIKGVSEIVHEGKKVKLTITYGSKVIHNEFTLGEECELETMTGEKVKAVVKMEGDNKMVTTFKGIKSVTEFNGDTITNTMTLGDIVYKRVSKRI
Protein: Hylin-b1 (Hy-b1) (P84002)
Organism: Boana lundii (Brazilian tree frog) (Hypsiboas lundii)
Function: Has hemolytic activity against human erythrocytes. May have antimicrobial activity.
Subcellular location: Secreted {ECO:0000269|PubMed:15638808}.
Interaction partners:
Sequence:
FIGAILPAIAGLVHGLINR
Protein: T-complex protein 1 subunit zeta (C6KST5)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- T-complex protein 1 subunit eta
- CCT-beta
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit gamma
- Phosducin-like protein 1, putative
- Prefoldin subunit 5, putative
- Type 2A phosphatase-associated protein 42, putative
Sequence:
MSIHLLNKKADSLRSTNVLMTNMNASKGMYEIIKSNLGPKGSYKMLVSSSGAIKITKDGNVLLNEMMIQHPTASMLSRICSSIDETLGDGSSSNLIVATSLIYLSEKYILYENIHPRIITQGFDIAKGILLEFLDSMKIPVNIEENFDKELLYNVCKTCIRTKLPICLADKLADDLVESIKIIYKPTKQIDLHMIEIMDIKRNMSINTKLVRGMVLDHGCRHPNMPNKLTKCFILVLNVSLEYEKSEVFSSFVYSNAEDRDKLVESERKFTDDKVKKIIELKKILVEKKFKETNEIYNFAVFNQKGIDPISLDLLAKENIMALRRIKRRNLERIVLCCGGNPCNNVYDLTEEDVGYAGLVYEISINDEKYTFIEEVQNPKSCTIFIQAPNDYTIKQIKDAIRDGLRSIKNVIDDKCVLSGAGSFEIMAYCKLKDEEKKIKGKQKFALDIYANSLLNIPKVLLENSGLDIHQTLFNVIDKYNEDRSEPLGLDLDTGEPIIAHLKGIYDNYCVKKEILSIATAISQQILLVDEIIRAGKSMGEEK
Protein: GH14278p (Q9VIM0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MILRDMGEATVRAALLAVLGILLIAGCDCSQRFKYEIKEFQVPLDHFSFLINATFNIRYLYNDSFVDKSNARTPIFFYTGNEGDIELFAQNTGFLWEQAERQRALVIFAEHRYYGKSLPFGSSTFNTSLPEHLAYFTVEQTLEDYAMLITFLRNDRQMPVVAFGGSYGGMLAAWFRMKYPHLVNGALAASAPVLQFPGITDCDIFYRIVTSVFQNAYNENCTLNIAKSWKLFETLGASEAGKKQISDAFHLCNALKNDDDLKKFLDYVEEVYSNLAMVNYPYNSSFLAPLPAYPVRQVCYYLKELHSTDADLLHAMSSALAVYTNYTQSAKCLDISVNSNADDSGWNIQSCNQMVMPICSNGSETMFRTSSWNFKDYAEKCYKNYRLTPKPYDIILRYGGRNLEAATNIIFSNGLLDPWSGGGVLQAPNDKVFVIILPEGAHHLDLRHSDPADPPSVRDARDKEAAIIARWIQDF
Protein: LD10016p (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform C) (Uncharacterized protein, isoform D) (Uncharacterized protein, isoform F) (Uncharacterized protein, isoform G) (Q9W3C3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTFPSFADISAKFSEATLDEIIRNAGGTRHTSYKFGPSGKKGDAYLSRVFRITIYGVKEAEEGQDEKQLEISVIVKAMPDNLHRRRLFRSVIFFRNEINFYTKVLPAIEAFQKSRQPAPKKPFVEYPRCLASLCDGVNDFIALEDVGPRGYRAPVRQDYISLEDALLTMRTLGRFHGVALAFNALDSKNFEKAAGSLEETYYGEHTREWYTGFLLLAENVATDAVKQIYPNSKYETVATNFLQPPLFDDLINLVSTRSKLSVFGHGDCWTPNFLTKYNERGQSEEIIIIDFQLARCSSLALDLSFFIYSCTSQELREQHYDELLRAYLESAQDLIQDLGGNAESIISWESLQEELKNFGRFGCGMGIESLPMTMMEDDEVADLDGIKENAILTDIWNITPFKESAKQQRLADIFKHAIDQGYIK
Protein: tRNA threonylcarbamoyladenosine dehydratase 1 (EC 6.1.-.-) (t(6)A37 dehydratase 1) (P38756)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
Subcellular location: Mitochondrion outer membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Elongator complex protein 3
- tRNA pseudouridine
- Ubiquitin-related modifier 1
- Elongator complex protein 6
- Cysteine desulfurase, mitochondrial
Sequence:
MANNTWKLIATTALISVFSTQLAKSVWKEYKLSCAANKNKTVSRPRQYDDHLFREQLARNYAFLGEEGMRKIKEQYIVIVGAGEVGSWVCTMLIRSGCQKIMIIDPENISIDSLNTHCCAVLSDIGKPKVQCLKEHLSKIAPWSEIKARAKAWTKENSHDLIFADGESPTFIVDCLDNLESKVDLLEYAHHNKIDVISSMGVATKSDPTRVSINDISMTEFDPISRCVRRKLRKRGIATGISVVFSNEMLDPRRDDILSPIDCEHRAINAVRDEALRHLPELGTMPGIFGLSIATWILTKVSGYPMKENEVKNRLKFYDSILETFQKQMARLNENKERSSLLGLEEVGYIVEEMFRGKSPISGYSTKLALTKWEANKEISLTNVVLMTKEEQEIHEKRILLDGEKLTAVYSEEVLDFIERLFKEEEYYS
Protein: Peptidase S1 domain-containing protein (A1ZAT2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRSLVSVALLSLLTLCVTENEHFKFLETPCGISTRPKISGGDDAAEPNSIWMAAIFNSSDFQCGGTIIHMRFVLSAAHCLVRGYDLYVRLGARNINEPAAVHTVINVFVHHDFIASEYRNDIGLLQLSESIVYTVRVQPICIFLDPALKGSVEKLKTFRALGWGNRNGKLSIMLQTIYLLHLKRNECKRKLNFNLNSRQICAGTKNGDTCRGDSGGPLSTNILFPSNKSYEVQLGIVSFGDPECRGVGVYTDVTSYVDWISSTIARNDYLPIGVSGGDIAMGNPIAPDANRHWTPAASPPLPSMLYNSCSQDIAAPIAQLRIYWPGSYAVGVLITDQLIIAAATDLPTVAAYLYVFVVLEGISAINQIESVSKHPNFTTNDYRNDIAVLKLVRSISSTAMKPICILTTQIYQQNAEKARELKIIDTDLAEQFDVRLMEGSQCAKHLGFQINENQVCMVDPSDTSNPRQKRSYIVVGGMNANGQIRYILVGIFSFSSKNILVFTNVMRHTDWILSLLYSLNTSS
Protein: Developmentally-regulated GTP-binding protein 2 (DRG-2) (Translation factor GTPase DRG2) (TRAFAC GTPase DRG2) (EC 3.6.5.-) (Q9QXB9)
Organism: Mus musculus (Mouse)
Function: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P55039}. Cytoplasm {ECO:0000250|UniProtKB:P55039}.
Interaction partners:
- RWD domain-containing protein 1
- Zinc finger CCCH domain-containing protein 15
- Stalled ribosome sensor GCN1
- Probable ATP-dependent RNA helicase DDX56
- RWD domain-containing protein 4
- RELT-like protein 1
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS3
- Developmentally-regulated GTP-binding protein 1
Sequence:
MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEPSKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGRGRGRQVIAVARTADVVVMMLDATKGDVQRSLLEKELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVLFREDCSPDDFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVISCGMKLNLDYLLEMLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKYALVWGTSTKYSPQRVGLTHTMEHEDVIQIVKK
Protein: Protein-arginine kinase (EC 2.7.14.1) (Q2G0P6)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions.
Interaction partners:
- Protein-arginine kinase activator protein
- Transcriptional regulator CtsR
- ATP-dependent Clp protease ATP-binding subunit ClpC
- Low molecular weight protein-tyrosine-phosphatase PtpB
- Chaperone protein ClpB
Sequence:
MTHNIHDNISQWMKSNEETPIVMSSRIRLARNLENHVHPLMYATENDGFRVINEVQDALPNFELMRLDQMDQQSKMKMVAKHLISPELIKQPAAAVLVNDDESLSVMINEEDHIRIQAMGTDTTLQALYNQASSIDDELDRSLDISYDEQLGYLTTCPTNIGTGMRASVMLHLPGLSIMKRMTRIAQTINRFGYTIRGIYGEGSQVYGHTYQVSNQLTLGKSELEIIETLTEVVNQIIHEEKQIRQKLDTYNQLETQDRVFRSLGILQNCRMITMEEASYRLSEVKLGIDLNYIELQNFKFNELMVAIQSPFLLDEEDDKSVKEKRADILREHIK
Protein: Cyclopropane-fatty-acyl-phospholipid synthase (CFA synthase) (Cyclopropane fatty acid synthase) (EC 2.1.1.79) (P0A9H7)
Organism: Escherichia coli (strain K12)
Function: Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MSSSCIEEVSVPDDNWYRIANELLSRAGIAINGSAPADIRVKNPDFFKRVLQEGSLGLGESYMDGWWECDRLDMFFSKVLRAGLENQLPHHFKDTLRIAGARLFNLQSKKRAWIVGKEHYDLGNDLFSRMLDPFMQYSCAYWKDADNLESAQQAKLKMICEKLQLKPGMRVLDIGCGWGGLAHYMASNYDVSVVGVTISAEQQKMAQERCEGLDVTILLQDYRDLNDQFDRIVSVGMFEHVGPKNYDTYFAVVDRNLKPEGIFLLHTIGSKKTDLNVDPWINKYIFPNGCLPSVRQIAQSSEPHFVMEDWHNFGADYDTTLMAWYERFLAAWPEIADNYSERFKRMFTYYLNACAGAFRARDIQLWQVVFSRGVENGLRVAR
Protein: Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (Q9CWL8)
Organism: Mus musculus (Mouse)
Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity). Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Pleiotropic regulator 1
- Cell division cycle 5-like protein
- Spliceosome-associated protein CWC15 homolog
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor SPF27
- Pre-mRNA-splicing factor SYF1
- Heat shock cognate 71 kDa protein
- Crooked neck-like protein 1
- Splicing factor U2AF 65 kDa subunit
- SNW domain-containing protein 1
Sequence:
MDVGELLSYQPNRGTKRPRDDEEEELKTRRKQTGPRERGRYREEEATAAEDTADDKKRLLQIIDRDGEEEEEEEEPLDESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVATMPDLYHLLVELSAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVAALLVQNLERLDESVREEADGVHNTLAIVENMAEFRPEMCTEAAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDALCSCLMLSSNRERFLKGEGLQLMNLMLREKKVSRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLSAMQVADKKIEGEKHDIVRRGEIIDNDMEDEFYLRRLDAGLFILQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRETEQKRILALLENF
Protein: Large ribosomal subunit protein eL31 (60S ribosomal protein L31) (Q6FWF4)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL32
- L21
- 60S acidic ribosomal protein P0
- L23
- Small ribosomal subunit protein eS6
- 60S ribosomal protein L36
- Candida glabrata strain CBS138 chromosome M complete sequence
- Large ribosomal subunit protein uL23
- RP41
Sequence:
MAGLKDVVTREYTINMHKRLHGVSFKKRAPKAVKEIKKFAKLHMGTEDVRLAPELNQEIWKRGVKGVAFRLRLRISRKRNEEENAKNPLFSYVEPVFVASAKGLQTTVVEEDA
Protein: Ankyrin 2, isoform G (A8JNM4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MVTENGAQGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDNMLSDQPYRYLTVDEMKSLGDDSLPIDVTRDERMDSNRMTQSAEYASGVPPTIGEEVISPHKTQVYGSSPKATVDGVYIANGSGHDEPPHVGRKLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPSRSTCQPTRVTCRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKEREIIILRSDNGETWREHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSRIRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQAQPVDPDLTAKLLGRGVAVSPIVTVEPRRRKFHKAITLSMPAPKAHSQGMINQYSGNTPTLRLLCSITGGPSRAQWEDVTGSTPLTFVNDCVSFTTTVSARFWLMDCRNISDATKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKLRVFCMTDDREDKTLEKHELYTEVAKSRDVEVLEGKPQYIEMAGNLVPVTKSGDQLQVQFKAFRENRLPFTVRVKDQHADIVGRTLFMKEPKVAKGEPPQQPICILNIVLPEAVIPDSTTAFSDRVTSAYRTSMFSLSKHQNDHYIGDIRIVDLSNLLGKDWIQLAPEIGINGEEIDEIINQNTDSIARQAQSMIRLYKDKPNYDILSLETALKNIGRDDIMKKCKSGRLSHSREFDEADLMKNSESVEELVRRESKRIQQINEREEVKYSAEEKEVEESESDEEAAKRTVAERREKIVKRLSIERSIPASTQKKEITREITEIKRKSLIEDKKAHHESEILMQLPADNVIIKTTTVPDQVIKMKMGKMDSTEVSKSEFDKELTHKFKTSGRSSEEEDQPSYPDQTDKIVQDISAAEKKEKDGVTFSRVTTITRQEARDITEDFLEIEKRSQLPATSTTATVHEKFVEEIKEKTSPLASVPQETVKEVQQVISEVTEIASKKVENIISSFESSKSVDATTVLPTQPSVESTKVSETIKNLEDAKAVSAEQVKTVHVVESSSIEETIAEFEAKKVKYDFHGGEPKTQIPKFTRKPSDDSMKPTAAPRATVESETESVLETKAEKPISKIPVKTIPTEAQKVSEVDARKITQDFLQGEKLAAEPKPSPAASKIPKVEPRKSVDKQVDRESKILDDVVASTATIMTAGLGDEQLKDQLVDHSEIIAKSETVAEKVTELLDTFHKIEEKVTKSEKTSEISSKVEELVKIEEKPLSQVQPKEDKVAEKVAEVIETFHKIEEKITTADARELTRDFLSMEQQNQLPSMPQAAEKPLESSLTSTSASEPESIVTVKPSPPASKIPVVEPRKIVFDESTKPLIEPEPVKTTEKKPLNERQLTADFLSMEQQTQLVSEPAKSLVEEVMKSAEQMVEQPKQQKSLNERQLTEDFLLMEQQTQLPSDIVKPTDKLIDGIESAAPVGDEASPFHTPKLTTSVVTQEPQQLASEYDSDTFGKQATIPLGDSKIDQGLIAPVSMEPRKSLTDAEFCKSVGETITKKMSVGVIEISDELKKIESEIPHSQTPPPTPSDNKTDKQNEEPELISLERDYLADTVTTLHTTTESTLERVSAITKIETLHERKVELSNLDTEKISHEIDPVAVLESVPVSFPVASSRNQTEDESETRARRIDHKIEKLSTDMDDVSARFDEAFEMSVPEDEISALQGDFSKLSWDESVSPTTNTMADMAQNQITPDNDIQDLIADKALF
Protein: CFA20 domain-containing protein (Q38C25)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cilia- and flagella-associated protein 45
- Uncharacterized protein
- Tubulin alpha chain
- ODAD1 central coiled coil region domain-containing protein
- Katanin p60 ATPase-containing subunit A-like 2
- Zinc carboxypeptidase, putative
- Uncharacterized protein
- Uncharacterized protein
- Enkurin domain-containing protein
- Enkurin domain-containing protein
Sequence:
MFHNSYQSGFLSILYSIGSRPLQIWDTKVRNGHVKRITDEDIQSSVLEVVGNNVSTCYITCPVDPKKTLGIKLPFLVMIIKNLKRYFSFEVTILDDKGIRRRFRASNYQTTTRVKPFTCTMPMRLDEGWNQIQFNLADFTRRAYGTNYLETLRVQLHANCRVRRLYFSDRLYSEEELPPEFKLFLPIAQQQQQQQQQQQQQQHMQKQAPPEPQQQQHHQQQQVHSEAHQQQQAPPEAQHQQAHSEAHQQQQYQQQVQHSQFQDAAPPSQQQTHEEMPQGEEEEQQQQTSPVEGA
Protein: Ceroid-lipofuscinosis neuronal 6 late infantile variant isoform 1 (A0A024R601)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEATRRRQHLGATGGPGAQLGASFLQARHGSVSADEAARTAPFHLDLWFYFTLQNWVLDFGRPIAMLVFPLEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSPRTLPRSITYVSIIIFIMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCMWYIPFFLILFMYFSGCFTASKAESLIPGPALLLVAPSGLYYWYLVTEGQIFILFIFTFFAMLALVLHQKRKRLFLDSNGLFLFSSFALTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPWAFYTLHVSSRH
Protein: Protein air1 (Q9P795)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the TRAMP (TRF4) and TRAMP5 complexes which have a poly(A) RNA polymerase activity and are involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- ATP-dependent RNA helicase mtr4
- Poly
- Poly
- Poly
- Exosome complex exonuclease dis3
- Uncharacterized RNA-binding protein C3H8.09c
- Uncharacterized helicase C17H9.02
- Putative ATP-dependent RNA helicase C550.03c
- Exosome complex component rrp45
- Exosome complex component csl4
Sequence:
MDMTVSNQKAESDDGSDIDDAALLQKINSLPIDQSITNSVSLEKHDFQGSDDHDSSTDLSDSTLEDVEGSEWADVSRGRYFGSDPSESIVCHNCKGNGHISKDCPHVLCTTCGAIDDHISVRCPWTKKCMNCGLLGHIAARCSEPRKRGPRVCRTCHTDTHTSSTCPLIWRYYVEKEHPVRIDVSEVRKFCYNCASDEHFGDDCTLPSRSNYPESTAFCEANCPSGNDASNKEFFETRRKEFQLERREQNRNQKSSKQRPFHKPGNSLASRLGSKPKSFKRKHSPPSEENGNLSFHSSDGRKFTKTSKKNRKRKW
Protein: Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (mCPEB-4) (Q7TN98)
Organism: Mus musculus (Mouse)
Function: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (By similarity). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (By similarity). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT. Stimulates proliferation of melanocytes (By similarity). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27381259}. Cell projection, dendrite {ECO:0000269|PubMed:17024188, ECO:0000269|PubMed:24386439}. Cell projection, dendritic spine {ECO:0000269|PubMed:24386439}. Postsynaptic density {ECO:0000269|PubMed:17024188}. Cell projection, axon {ECO:0000269|PubMed:27381259}. Cell projection, growth cone {ECO:0000269|PubMed:27381259}. Endoplasmic reticulum {ECO:0000269|PubMed:28092655}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:28092655}.
Interaction partners:
- Aurora kinase A
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase PLK1
- G2/mitotic-specific cyclin-B2
- Fragile X messenger ribonucleoprotein 1
- RNA-binding protein FXR1
- RNA-binding protein FXR2
- Cytoplasmic polyadenylation element-binding protein 2
- Polyadenylate-binding protein 1
- Poly
Sequence:
MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPNPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKAEENPGDSSSENSNGKEKLRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPGASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRSAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGASQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPERPRTFDMHSLESSLIDIMRAENDSIKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFTHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN