wanglab/gogpt-training-data huggingface dataset:
Protein: Protein DENND6B (DENN domain-containing protein 6B) (Q8NEG7)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.
Subcellular location: Recycling endosome {ECO:0000305}. Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MDALLGTGPRRARGCLGAAGPTSSGRAARTPAAPWARFSAWLECVCVVTFDLELGQALELVYPNDFRLTDKEKSSICYLSFPDSHSGCLGDTQFSFRMRQCGGQRSPWHADDRHYNSRAPVALQREPAHYFGYVYFRQVKDSSVKRGYFQKSLVLVSRLPFVRLFQALLSLIAPEYFDKLAPCLEAVCSEIDQWPAPAPGQTLNLPVMGVVVQVRIPSRVDKSESSPPKQFDQENLLPAPVVLASVHELDLFRCFRPVLTHMQTLWELMLLGEPLLVLAPSPDVSSEMVLALTSCLQPLRFCCDFRPYFTIHDSEFKEFTTRTQAPPNVVLGVTNPFFIKTLQHWPHILRVGEPKMSGDLPKQVKLKKPSRLKTLDTKPGLYTAYTAHLHRDKALLKRLLKGVQKKRPSDVQSALLRRHLLELTQSFIIPLEHYMASLMPLQKSITPWKTPPQIQPFSQDDFLRSLEHAGPQLTCILKGDWLGLYRRFFKSPHFDGWYRQRHKEMALKLEALHLEAICEANIETWMKDKSEVEVVDLVLKLREKLVRAQGHQLPVKEATLQRAQLYIETVIGSLPKDLQAVLCPP
Protein: Rho guanine nucleotide exchange factor 6 (Alpha-PIX) (Rac/Cdc42 guanine nucleotide exchange factor 6) (Q8K4I3)
Organism: Mus musculus (Mouse)
Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Subcellular location: Cell projection, lamellipodium {ECO:0000269|PubMed:18325335}.
Interaction partners:
- Beta-parvin
- ARF GTPase-activating protein GIT1
- Serine/threonine-protein kinase PAK 3
- Serine/threonine-protein kinase PAK 2
- Serine/threonine-protein kinase PAK 1
- Serine/threonine-protein kinase PAK 4
- Rho guanine nucleotide exchange factor 7
- Ras-related C3 botulinum toxin substrate 2
- Ras-related C3 botulinum toxin substrate 3
- Serine/threonine-protein kinase PAK 5
Sequence:
MNPEERLVTWLISLGVLESPKKTVCDPEEFLKSSLKNGVVLCKLINRLLPGSVEKYCLEPQTEADCIDNINDFLKGCATLQVEVFEPDDLYSGANFSKVLNTLLAVNKATEDQLSERPCGRSSSLSAATSSQTNPQVAVPSTAPEQHSEEKAEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKPSERPLSPKAIKGFDTAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEFTCLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLNLMPHFKSMYLAYCANHPSAVNVLTQHSDDLERFMENQGASSPGILILTTSLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIIAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGDDIKTLGNVIFMSQVVMQHGACEEKEERYFLLFSSVLIMLSASPRMSGFMYQGKIPIAGMVVNRLDEIEGSDCMFEITGSTVERIVVHCNNNQDFQEWMEQLNRLTKGPTSCGSLSKTSSSSCSTHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKASEEEYVIRKSTAALEEDAQILKVIEAYCTSASFQQGTRKDSVPQVLLPEEEKLIIEETRSNGQTIIEEKSLVDTVYALKDEVKELKQENKKMKQCLEEELKSRKDLEKLVRKLLKQTDECIRSESSSKTSILQ
Protein: Perilipin 1 (F1SK18)
Organism: Sus scrofa (Pig)
Subcellular location: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
Interaction partners:
Sequence:
LPIQGGLKLQRGGAPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGIQSAGSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPVTSTADKVLGAALAGCELAWGMAKDTAEYAANTRAGRLASGGADLALGGVEKVVELLLPPAKEESASAPGHQHGQKPPKAKPSLVSRVGTLASTISQHTFQATSRALKQGHALAMWIPGVAPLSSLAQWGASAAMQVVSRRQSVVRVPWLHNLAATQEEDHDDQTDTEGEEMEEEAEPETEENKLSEGAALPGPQGFLGKAVHTLQRALQSTISLVTWAPATALGTAGRMLPFTPARAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPPEAERREAERRGSGALPAAPEAAPRPAPTRGSLRSARGPGAEDRGTPLPRCAPPSRQCPARSRRAGSATASSGPASWSPSWAARSTTSCARRAELASRARPGPARAPPAPPRARALSPANQKNLRGQASVPSFVPRTLPRHTSSFEHPFGA
Protein: Nuclear Pore complex Protein (Q21021)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSDQKPNMGRIVASVVDVQQLMTMQFDSLIKSMDSLKIEHQTGVTQLRDDIRRSEDRFQKQLSDLSTNHGKELERLHQIIHTLLARDANPLGSMIPPQQLQQQQQMLILQRQMEMAHVQAAQAQAHAHAQAQAQAQAQSQVMANLLNAAKPAIPVTQPLVATTAQAKSTVPASGVIAPKTSPPEVVIPPAKPTFSTPTPAVVPKPATTGFSFGGTNPATSIFGKKPETASPVVVPAAKDDEDEEHDEDYEPEGEFKPVIPLPDLVEVKTGEEGEQTMFCNRSKLYIYANETKEWKERGTGELKVLYNKDKKSWRVVMRRDQVLKVCANFPILGSMTIQQMKSNEKAYTWFCEDFSEDQPAHVKLSARFANVDIAGEFKTLFEKAVAEAKSSSNAGKTIDKEIKPAAEVKKEVKQEVVIPSNNKPEETGFGDQFKPKPGSWECPGCYVTCKADEIECACCGTSKDGSVKEKNIFSKPSILQPAPGTPKVTFGFGASAPAKEPLAQTSQFGGSLSGSPSTSSSIFGGGTPKGTSVFGGGAANTPTFSFNKPAAAVNATTPSFNFNNPAASTASPATSTTPGNSLFGGGLSKTESTASSTTTPSFMFAKNSESAFPKPTFSFGKQQTPSTTAPAKQEENKQSETPKSVFGSGFTSGGATFAALSANSAKSGSIFDAANVKKAQEELAAQKKASIFGSKNTTLNTTSATSHDGDETNEDGDGEYEPEVEFKPVIPLPDLVEVKTGEEDEEVMFSARCKLYKYYSDLKENKERGLGDIKLLKSNDNKYRIVMRREQVHKLCANFRIEKSMKLSPKPNLPNVLTFMCQDFSEDASNADPAIFTAKFKDEATAGAFKTAVQDAQSKM
Protein: Insulin receptor substrate 3 (Irs3 protein) (Q4QQK2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MKPAGTGPTVSSGGECTDVSLGSPFPWPCLPDVRLCGHLRKQKSQRRRFFVLRADPPRLECYESEKKFLASGCRPPRPRRTVSLEGACTISKRADARQRHLIVIYTSDSSLGVAAASEAEQQAWYSALLEVRATAAAAAATAMGFSPQEAPESWIFAPFQDVWPVTLRSKGLGRAQGLSSGSYRLCLGSGALSLLRKPGSKGSRDSRATPPPVLRLSLLSVRRCGHADSFFFLELGRSAPIGPGELWLQAPDAVVAQSIHETVLAAMKRLGSNAAGKAEPPPQGNPPKSVPAAPTPTPYEIPASAAQARSPSERAKQDYFKPLERMGSTHSYKGLDLGGNYITMGVRNDYVHMGGGEAERNS
Protein: Nitrogenase iron protein 1 (EC 1.18.6.1) (Nitrogenase Fe protein 1) (Nitrogenase component II) (Nitrogenase reductase) (P00459)
Organism: Azotobacter vinelandii
Function: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein (component 2) and a component 1 which is either a molybdenum-iron protein, a vanadium-iron, or an iron-iron protein.
Interaction partners:
Sequence:
MAMRQCAIYGKGGIGKSTTTQNLVAALAEMGKKVMIVGCDPKADSTRLILHSKAQNTIMEMAAEAGTVEDLELEDVLKAGYGGVKCVESGGPEPGVGCAGRGVITAINFLEEEGAYEDDLDFVFYDVLGDVVCGGFAMPIRENKAQEIYIVCSGEMMAMYAANNISKGIVKYANSGSVRLGGLICNSRNTDREDELIIALANKLGTQMIHFVPRDNVVQRAEIRRMTVIEYDPKAKQADEYRALARKVVDNKLLVIPNPITMDELEELLMEFGIMEVEDESIVGKTAEEV
Protein: Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) (Q00788)
Organism: Rattus norvegicus (Rat)
Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:1534150}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30518}.
Interaction partners:
- Vasopressin-neurophysin 2-copeptin
- Beta-arrestin-1
- Aquaporin-2
- Vasopressin V1a receptor
- Guanine nucleotide-binding protein G
- Beta-arrestin-2
- Vasopressin V1b receptor
- Neuroendocrine secretory protein 55
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
Sequence:
MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
Protein: Pentatricopeptide repeat-containing protein At5g48910 (Q9FI80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Phosphoglycerate mutase family protein
- Organelle RRM domain-containing protein 1
- Organelle RRM domain-containing protein 6
- Multiple organellar RNA editing factor 9, chloroplastic
- Zinc finger protein VAR3, chloroplastic
- Multiple organellar RNA editing factor 8, chloroplastic/mitochondrial
- Multiple organellar RNA editing factor 2, chloroplastic
- Cytochrome b559 subunit beta
Sequence:
MNPTQTLFSPGGNSPASSPASHPSSLFPQINNCRTIRDLSQIHAVFIKSGQMRDTLAAAEILRFCATSDLHHRDLDYAHKIFNQMPQRNCFSWNTIIRGFSESDEDKALIAITLFYEMMSDEFVEPNRFTFPSVLKACAKTGKIQEGKQIHGLALKYGFGGDEFVMSNLVRMYVMCGFMKDARVLFYKNIIEKDMVVMTDRRKRDGEIVLWNVMIDGYMRLGDCKAARMLFDKMRQRSVVSWNTMISGYSLNGFFKDAVEVFREMKKGDIRPNYVTLVSVLPAISRLGSLELGEWLHLYAEDSGIRIDDVLGSALIDMYSKCGIIEKAIHVFERLPRENVITWSAMINGFAIHGQAGDAIDCFCKMRQAGVRPSDVAYINLLTACSHGGLVEEGRRYFSQMVSVDGLEPRIEHYGCMVDLLGRSGLLDEAEEFILNMPIKPDDVIWKALLGACRMQGNVEMGKRVANILMDMVPHDSGAYVALSNMYASQGNWSEVSEMRLRMKEKDIRKDPGCSLIDIDGVLHEFVVEDDSHPKAKEINSMLVEISDKLRLAGYRPITTQVLLNLEEEDKENVLHYHSEKIATAFGLISTSPGKPIRIVKNLRICEDCHSSIKLISKVYKRKITVRDRKRFHHFQDGSCSCMDYW
Protein: Probable ADP-ribosylation factor GTPase-activating protein AGD6 (ARF GAP AGD6) (Protein ARF-GAP DOMAIN 6) (AtAGD6) (Protein ZIGA2) (Q9M354)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTPase-activating protein (GAP) for ADP ribosylation factor (ARF).
Interaction partners:
- Probable ADP-ribosylation factor GTPase-activating protein AGD9
- Probable ADP-ribosylation factor GTPase-activating protein AGD8
- ADP-ribosylation factor GTPase-activating protein AGD10
- Coatomer subunit delta
- ADP-ribosylation factor GTPase-activating protein
- At5g48430
- Peroxidase 62
- Classical arabinogalactan protein 10
- Coatomer subunit epsilon-1
- Coatomer subunit epsilon-2
Sequence:
MAATRQLRTLQSQPENKVCVDCAQKNPQWASVSYGIFMCLECSGKHRGLGVHISFVRSVTMDSWSAIQIKKMEAGGNERLNKFFAQYGIAKETDIISKYNSNAASVYRDRIQALAEGRPWNDPPVVKEANKKPPLAQGGYGNNNNNNNGGWDSWDNDDSYKSDMRRNQSANDFRASGNREGAHVKSKSSEDIYTRSQLEASAAGKESFFARRMAENESKPEGLPPSQGGKYVGFGSSSAPPPRNNQQDDVFSVVSQGFGRLSLVAASAAQSAASVVQTGTKEFTSKVKEGGYDHKVSETVNVVANKTTEIGHRTWGIMKGVMAMATQKVEEFTKEGSTSWNQQSENEGNGYYQNFGNGNKAANSSVGGGRPQSSSTSGHYNNSQNSNSWDSWGENENKKTEAVAPKGSSASNDDDGWTGWDDHDAKDDGFDGHYQSAGDKKSAGHNGKSDTAWTGGGFL
Protein: WD repeat domain 47 (G3V9M3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Calmodulin regulated spectrin-associated protein family, member 3
- F-box protein 33
Sequence:
MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHLEFTMQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEVCVMVAEFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLCGNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSPYPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGVQNLSRSLLLENTECHSIYEESPERSDTPVETQQPVSIEPMCQGSGLEKEPANGAQNPVPAKQQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLTEQFLNRSIQKLGELNIGMDSLGNEVPVLNQQCLGSKNSGSNNSSVTSFSSPPQDSSQRLTHDTSNIHTSTPRNPGSTNHIPFLEESPCGSQNSSEHSVVKPSPGDSSGSLSRSKGEEDDKSKKQFVCINTLEDTQAVRAVAFHPSGSLYAVGSNSKTLRVCAYPEKLDTSAHDGPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYSG
Protein: Brahma associated protein 111kD (DALAO protein) (LD41296p) (Q9W384)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Bromodomain containing 7/9
- Brahma associated protein 55kD
- ATP-dependent helicase brm
- Brahma associated protein 155 kDa
- Brahma-associated protein of 60 kDa
- Polybromo
- GH08712p
- Brahma associated protein 170kD
- Supporter of activation of yellow protein
- Trithorax group protein osa
Sequence:
MALPSNYKQIAVGGQGSATPLQGGGGGSGGGSRSRSSGGGGGGDRNKDQTPIFTHSNYGNPAFTPQKVTKSSSSKNQNESRLPKPPKPPEKPILPYMRYSKRVWDSVKAKHPELKLWELGKKIGAMWKLLPEDEKTEFIDEYEAEKLEYEKSLKAYHQTPAYQAYMSAKSKVKTDVDMHETPSRGGGSKSQHERRIDIQPAEDEDDQDEGYTTKHLAYARYLHNHRLINEIFSEAVVPDVRSVVTTTRMQVLKRQVSSLTMHQTKLEAELQQMEEKFEAKKQRMVESSEAFQEELKRHCKPAVDEETFQKMVLRMYEDIKRDRQRLDEPNANANSAANPAAAAATAAAAPVTRSEEAVKPPTQPGQPAATPAGQEPASAVPAPAAPPKETPPAVKPATLNPTPSSTPTPAPAVHVHETASKTDPEPMDIEPPPKPSVPPPPIKPEKLEMAAALPPQSTLVEPPKTEPAKVVAQPGKVPTPVPTPTPPPEVAPAAGAATAATTTTTTTPTPPPVPQQVPLPQQQGGPAPPPGMPQMHPHPGHPPPGHSLMPPHMGPHQPPPGMPGLPPPPPHTGYANYGGPPHGPPPGPPGGPARPYYQPQYGGHPTPQPYYAPFSPYQQSYGPPPGSHYMSPRPPPPQHNGNPGHPYAPEHGSNPPPPQQQQQQQPPPGHLHEPSGGGPGAPGGGAGAAAAAAPGAGVYPTPGAGAGPGAPPGPAGGAPLGEAAVAGGVAPPAATAPGKHPEAEKHEAD
Protein: Thymosin beta-4 (Q0P5Q0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
NSVVATAQTRLRSYSCASLCFSSATMSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
Protein: FYVE and coiled-coil domain autophagy adaptor 1 (C9J2W6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPVGQDSEICLLKSGELMIKVPLTVDEIASFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRTPGIYMLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFL
Protein: Protein glycosylation K (EC 7.5.2.5) (Q0P9C4)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Function: Mediates the ATP-dependent translocation of the undecaprenylpyrophosphate-linked heptasaccharide intermediate across the cell membrane; this is an essential step during the N-linked protein glycosylation pathway. Transport across the membrane is effected via ATP-driven conformation changes. Most likely, only the polar and charged part of the glycolipid enter the substrate-binding cavity, and the lipid tail remains exposed to the membrane lipids during the transmembrane flipping process.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:26266984}; Multi-pass membrane protein {ECO:0000269|PubMed:26266984, ECO:0000305}.
Interaction partners:
- N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase
- N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-alpha-N-acetylgalactosaminyltransferase
- GalNAc-alpha-
- AAA family ATPase
- Undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase
- GalNAc
- Undecaprenyl-diphosphooligosaccharide--protein glycotransferase
- UDP-N-acetylbacillosamine N-acetyltransferase
- UDP-glucose 4-epimerase
- beta-lactamase
Sequence:
MLKKLFFILSKEDKNFLFFLLVFSVFISFIETFAISLVMPFITLASDFSYFDRNKYLISLKEYLNIPVFEIIVYFGVGLIVFYVFRALLNAYYFHLLARFSKGRYHAIAYKVFSKFLNINYEKFTQKNQSEILKSITGEVYNLSTMISSFLLLMSEIFVVLLLYALMLLINYKITLFLSIFMVLNAFILVKILSPIIKKAGVRREEAMKNFFEILNTNLNNFKFIKLKTKEDGVLSLFKAQSEAFSKANITNESVAAVPRIYLEGIGFCVLVFIVVFLVLKNESDISGILSTISIFVLALYRLMPSANRIITSYHDLLYYHSSLDIIYQNLRQEEENLGEEKLSFNQELKICNLSFGYEGKKYLFKNLNLNIKKGEKIAFIGESGCGKSTLVDLIIGLLKPKEGQILIDEQELNANNTKNYRQKIGYIPQNIYLFNDSIAKNITFGDAVDEEKLNRVIKQANLEHFIKNLPQGVQTKVGDGGSNLSGGQKQRIAIARALYLEPEMLVLDEATSALDTQSEAKIMDEIYKISKDKTMIIIAHRLSTITQCDKVYRLEHGKLKEEK
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Q387G2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase
- Peptidyl-prolyl cis-trans isomerase
Sequence:
MSYRPHHATVPTNPKVYFDVSIAGQAAGRITFELFADAVPKTAENFRALCTGEKGFGYAGSGFHRIIPQFMCQGGDFTRHNGTGGKSIYGEKFPDESFAGKAGKHFGAGTLSMANAGPNTNGSQFFICTAPTQWLDGKHVVFGQVLEGMDVVKAMEAVGSQGGSTSKPVKIDSCGQL
Protein: Protein Mx1 (Q3UD61)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDSVNNLCRHYEEKVRPCIDLIDTLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLRKLKEGEEWRGKVSYDDIEVELSDPSEVEEAINKGQNFIAGVGLGISDKLISLDVSSPNVPDLTLIDLPGITRVAVGNQPADIGRQIKRLIKTYIQKQETINLVVVPSNVDIATTEALSMAQEVDPEGDRTIEMVQTAFVKILSNDFGDFLNLCCTAKSKIKEIRLNQEKEAENLIRLHFQMEQIVYCQDQVYKETLKTIREKEAEKEKTKALINPATFQNNSQFPQKGLTTTEMTQHLKAYYQECRRNIGRQIPLIIQYFILKTFGEEIEKTMLQLLQDTSKCSWFLEEQSDTREKKKFLKRRLLRLDEARQKLAKFSD
Protein: DNA-3-methyladenine glycosylase 1 (EC 3.2.2.21) (3-methyladenine DNA glycosidase 1) (3MEA DNA glycosylase 1) (Q92383)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions. Can release ethylated and propylated bases from DNA in addition to 3-methyladenine.
Interaction partners:
- Endonuclease III homolog lyase)
- Adenine DNA glycosylase
- DNA repair protein rad16
- DNA-
- G/U mismatch-specific uracil DNA glycosylase
- Uracil-DNA glycosylase
Sequence:
MTLDIEEKEEIVTSLTKAEIHLSGLDENWKRLVKLVGNYRPNRSMEKKEPYEELIRAVASQQLHSKAANAIFNRFKSISNNGQFPTPEEIRDMDFEIMRACGFSARKIDSLKSIAEATISGLIPTKEEAERLSNEELIERLTQIKGIGRWTVEMLLIFSLNRDDVMPADDLSIRNGYRYLHRLPKIPTKMYVLKHSEICAPFRTAAAWYLWKTSKLADYTKPVRPKKH
Protein: Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) (P97717)
Organism: Mus musculus (Mouse)
Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:22120526}; Multi-pass membrane protein {ECO:0000269|PubMed:22120526}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250|UniProtKB:P35368}. Membrane, caveola {ECO:0000250|UniProtKB:P35368}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-13
- Alpha-1A adrenergic receptor
- Alpha-1D adrenergic receptor
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Guanine nucleotide-binding protein subunit alpha-15
- Guanine nucleotide-binding protein subunit alpha-14
Sequence:
MNPDLDTGHNTSAPAHWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGCLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTDLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDTTTDLANGQPGFKSNMPLAPGHF
Protein: Receptor-transporting protein 4 (28 kDa interferon-responsive protein) (3CxxC-type zinc finger protein 4) (Q96DX8)
Organism: Homo sapiens (Human)
Function: Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16. Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Interaction partners:
- Interferon-induced protein 44
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Ubl carboxyl-terminal hydrolase 18
- Ubiquitin-like protein ISG15
- 2'-5'-oligoadenylate synthase 2
- 2'-5'-oligoadenylate synthase 1
- Interferon-induced 35 kDa protein
- Interferon-induced protein with tetratricopeptide repeats 3
- Interferon-induced GTP-binding protein Mx1
- Antiviral innate immune response receptor RIG-I
Sequence:
MVVDFWTWEQTFQELIQEAKPRATWTLKLDGNLQLDCLAQGWKQYQQRAFGWFRCSSCQRSWASAQVQILCHTYWEHWTSQGQVRMRLFGQRCQKCSWSQYEMPEFSSDSTMRILSNLVQHILKKYYGNGTRKSPEMPVILEVSLEGSHDTANCEACTLGICGQGLKSCMTKPSKSLLPHLKTGNSSPGIGAVYLANQAKNQSAEAKEAKGSGYEKLGPSRDPDPLNICVFILLLVFIVVKCFTSE
Protein: ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) (P19483)
Organism: Bos taurus (Bovine)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14633978, ECO:0000269|PubMed:23407638, ECO:0000269|PubMed:2864455, ECO:0000269|PubMed:95168}; Peripheral membrane protein {ECO:0000269|PubMed:14633978, ECO:0000269|PubMed:23407638, ECO:0000269|PubMed:2864455, ECO:0000269|PubMed:95168}; Matrix side {ECO:0000269|PubMed:14633978, ECO:0000269|PubMed:95168}. Cell membrane {ECO:0000250|UniProtKB:P25705}; Peripheral membrane protein {ECO:0000250|UniProtKB:P25705}; Extracellular side {ECO:0000250|UniProtKB:P25705}. Note=Colocalizes with HRG on the cell surface of T-cells. {ECO:0000250|UniProtKB:P25705}.
Interaction partners:
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit F6, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase peripheral stalk subunit b, mitochondrial
- ATP synthase F
- ATP synthase F
Sequence:
MLSVRVAAAVARALPRRAGLVSKNALGSSFIAARNLHASNSRLQKTGTAEVSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKARRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGTDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVISQHQALLSKIRTDGKISEESDAKLKEIVTNFLAGFEA
Protein: Golgi apparatus membrane protein tvp38 (Q9P781)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Golgi membrane protein involved in vesicular trafficking and spindle migration.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Uncharacterized protein C1711.08
Sequence:
MPAPVSSIKIIALAAIGILIVVFAILLAVFHNDLLAIAMPIAERIAKLPMSFLIALVLIAASSIPPLLGQDPLALLIGAVWGLNVGFWTVVCGIFIGETIAFMAYRYFLEQKAQEFREHHEEHYGTFVKIVEEGSYPLIWLIRLSFLPTHFTTVFFATLPELSYIGWAIAFWLSCFKYLVPVYAGYCIVHNKSSAANIVGIVLSIVVTLGTLAFLIVRYKAIKNSTLEDSTNSTSDVLNHLESQPTDSIDLRHLEQTSEQNETDNSERKHLLSHQH
Protein: Variant surface glycoprotein (VSG), putative (Q57Y76)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MLIRAFITLAFLFAQKVAETSADANKPCSTACGCKKRLHARLGLYTTKLKEAKQTNHQNLKEYNSLLLAAAVGSPLDTTIILPILAGSGELIQQCNEQISAADKAVAAATIKVGEASGVYNVIHKLKDGMGKLMINFGGGDLQLPASKFTSRTLGGINANACCSSNNGEEGVKTDLEHEPKEPEPTKLITHAYLEAKCDSNPGAPATCHNAAVDQDTQISIGLGFGNGAKDEKSAWGAGSHTKMHKIASTAVDFFSSNETAAHQALKALATDKTGLPACHSLQDFGAMAETRAFQLMLLKLAAGKPEAEKVGPDDRQDIDSAITSSYGKSGANYKDKIWDQIQKTEVPQGKQTGEKTAALEKGADIKLQTEALARLFAKEIKEKKQAKTTQKVSKTTDCNKQTEKTAEECKNLGCDHDAENKKCKPKAGTENTAPGAGATAGCTKHGTDKPKCEGDKSCKGNGKECKDSSFIVNKKLASMNAAFVSFIAF
Protein: Lysozyme g (EC 3.2.1.17) (C1BGU6)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MASCFGDIAKVDTSGASEITARQDKLTVQGVDASHKLAEHDLVRMNKYKKLITRVGQKHGLDPAIIAGIISRESRAGAVLDHGWGDHGNGFGLMQVDKRYHKIVGTWDSEEHISQGSEILKEFIRRIQAKFPAWPKEHQLKGGISAYNAGDRNVRTYERMDVGTTGGDYSNDVVARSQWFKRQGY
Protein: Acid shock protein (P36560)
Organism: Escherichia coli (strain K12)
Function: Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0).
Subcellular location: Periplasm.
Interaction partners:
Sequence:
MKKVLALVVAAAMGLSSAAFAAETTTTPAPTATTTKAAPAKTTHHKKQHKAAPAQKAQAAKKHHKNTKAEQKAPEQKAQAAKKHAKKHSHQQPAKPAAQPAA