wanglab/gogpt-training-data huggingface dataset:
Protein: Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase) (Q06667)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
Subcellular location: Nucleus {ECO:0000269|PubMed:10390371}.
Interaction partners:
- Inositol polyphosphate multikinase
- Inositol hexakisphosphate kinase 1
- mRNA export factor GLE1
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
Sequence:
MQVIGRGGANILIDYGDPTWLWRCCIRWPDLLSSNNSYTIKNISYIKDYVEPLLHGLLCPMYLIDVDIEAIRPILSDFILNLDDKVVKVIKIKNLTNNTSNLILNNHFLKSYCSQNLQTVILELKPKWLYYDTDYCRNCTHNAFKGRGTKYCYNQLLMNPAHLELIFGECNIFPVKFKDAMHEYLRNDNNIFKILYDLQKKLTKNTTPISDIKSINDVNDEHLLLMTLRDVTCFIEWNSAENALHVNIIDVDLKPKEKWTHWTKTYSQLTSSQKIYHTSNK
Protein: Cyclic nucleotide-gated channel beta-1 (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (E1AZ71)
Organism: Mus musculus (Mouse)
Subcellular location: Cell projection, cilium membrane {ECO:0000269|PubMed:16980309}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cyclic nucleotide-gated channel alpha-1
- Cyclic nucleotide-gated channel alpha-4
- Cyclic nucleotide-gated channel alpha-2
- Calmodulin-1
- Calmodulin 5
- Calmodulin-like protein 3
- Calmodulin-4
- Calmodulin-like protein 4
- Guanine nucleotide-binding protein G
- Cyclic nucleotide-gated channel alpha-3
Sequence:
MLGWVQRVLPQPPGTPQKTVETAGPQPETESKPEANPQPEPEPQQEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPVPEEAPPEVQALPPEEPMEGEGEAEAGPSLQETQVADPAQPTSQAQVAVAKVNRPSSWMLSWFWRGMQKVVPQPVCSNGGQNLAAGERDPDQGGAQIPEPCGTGDPGSAEASGTQDTEPSLWLLRWLEQNLEKVLPQPPPPSLAWKVEPEAAVLDPDPPGTPMQMEPTESPSQPNPGPLEPEEEPAAEPQPGFQSSSLPPPGDPVRLIEWLLHRLEMALPQPVLHGKAAEQEPGCPGMCDVQTISILPVEQVEHDLVLEEVDSCWEDAQQEDGASPQETEVAPAHEEESEAIVEIPRELTKIQEEREDEQEEDEEEKEEEKKKGEEEKEKEEEEKEKEKEKEEEKEEEEKEEEEEEEKEEEEEEKEEEEKEEEEKEEEEEEEEEEEEPIVLLDSCLVVQADVDECQLERTPSELASIQELPEEKEEKEEEKEEEKEEEEEKKEEEVEKKEEGEATNSTVPATKEHPELQVEDTDADSGPLIPEETLPPPERPPPSPVKSDTLTVPGAAAAGHRKKLPSQDDEAEELKALSPAESPVVAWSDPTTPQEADGQDRAASTASQNSAIINDRLQELVKMFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPDPAQKPAEAEVAEEEHYCDMLCCKFKRRPLKMYRFPQSIDPLTNLMYILWLFFVVLAWNWNCWLIPVRWAFPYQRADNIHFWLLMDYLCDFIYLLDITVFQMRLQFVKGGDIITDKKEMRNNYLKSRRFKMDLLCLLPLDFLYLKLGINPLLRLPRCLKYMAFFEFNNRLEAILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAFQGIGSTHWVYDGVGNSYIRCYYWAVKTLITIGGLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYSIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKAVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRNNNKPKEEKSVLILPPRAGTPKLFNAALAAAGKMGPRGAKGGKLAHLRARLKELAALEAAARQQQLLEQAKSSQEAGGEEGSGATDQPAPQEPPEPKDPPKPPGPPEPSAQSSPPPASAKPEESTGEAAGPPEPSVRIRVSPGPDPGEQTLSVEVLEEKKEGAE
Protein: Asparagine synthetase B [glutamine-hydrolyzing] (AS-B) (EC 6.3.5.4) (P22106)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the ATP-dependent conversion of aspartate into asparagine, using glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro, albeit with lower efficiency. As nucleotide substrates, ATP and dATP are utilized at a similar rate in both the glutamine- and ammonia-dependent reactions, whereas GTP utilization is only 15% that of ATP, and CTP, UTP, ITP and XTP are very poor or not substrates. Also exhibits glutaminase activity.
Interaction partners:
- Aspartate--ammonia ligase
- Bifunctional aspartokinase/homoserine dehydrogenase 1
- Bifunctional aspartokinase/homoserine dehydrogenase 2
- L-asparaginase 1
- L-asparaginase 2
- Aspartate carbamoyltransferase catalytic subunit
- Adenylosuccinate synthetase
- Argininosuccinate synthase
- Isoaspartyl peptidase
- Aspartate aminotransferase
Sequence:
MCSIFGVFDIKTDAVELRKKALELSRLMRHRGPDWSGIYASDNAILAHERLSIVDVNAGAQPLYNQQKTHVLAVNGEIYNHQALRAEYGDRYQFQTGSDCEVILALYQEKGPEFLDDLQGMFAFALYDSEKDAYLIGRDHLGIIPLYMGYDEHGQLYVASEMKALVPVCRTIKEFPAGSYLWSQDGEIRSYYHRDWFDYDAVKDNVTDKNELRQALEDSVKSHLMSDVPYGVLLSGGLDSSIISAITKKYAARRVEDQERSEAWWPQLHSFAVGLPGSPDLKAAQEVANHLGTVHHEIHFTVQEGLDAIRDVIYHIETYDVTTIRASTPMYLMSRKIKAMGIKMVLSGEGSDEVFGGYLYFHKAPNAKELHEETVRKLLALHMYDCARANKAMSAWGVEARVPFLDKKFLDVAMRINPQDKMCGNGKMEKHILRECFEAYLPASVAWRQKEQFSDGVGYSWIDTLKEVAAQQVSDQQLETARFRFPYNTPTSKEAYLYREIFEELFPLPSAAECVPGGPSVACSSAKAIEWDEAFKKMDDPSGRAVGVHQSAYK
Protein: Orsellinic acid synthase (OAS) (EC 2.3.1.-) (Non-reducing polyketide synthase orsA) (Orsellinic acid/F9775 biosynthesis cluster protein A) (Q5AUX1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B. The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B. The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B.
Interaction partners:
Sequence:
MAPNHVLFFPQERVTFDAVHDLNVRSKSRRRLQSLLAAASNVVQHWTASLDGLERADIGSFEDLVELAERQTTQTRGSIVADLVLLTTVQIGQLLVLAEDDPAILSGHAGARAIPMGFGAGLVAAGVAAAATSADGIVNLGLEAVSVAFRLGVELQRRGKDIEDSNGPWAQVISSATTIADLEQALDRINASLRPINQAYIGEVMTESTVVFGPPSTLDALAKRPELAHATITSPASALAQVPLHGAHLPPISATMIAASSSQQATELWKLAVEEVANKPIDVHQAVTALIHDLHRANITDIVLTAIGASTETSGIQSLLEKNGLAVELGQLSPTPRPYGNDLDSIPADAIAVVGMSGRFPNSDTLDEFWRLLETATTTHQVIPESRFNVDDFYDPTRAKHNALLARYGCFLKNPGDFDHRLFNISPREAMQMDPVQRMLLMTTYEALEMAGYSPPTPAAPGDSEQAPPRIATYFGQTIDDWKSINDQQGIDTHYLPGVNRGFAPGRLSHFFQWAGGFYSIDTGCSSSATALCLARDALTAGKYDAAVVGGGTLLTAPEWFAGLSQGGFLSPTGACKTYSDSADGYCRGEGVGVVILKRLADAVRSKDNVIAVIAGASRNCNAGAGSITYPGEKAQGALYRRVMRQAAVRPEQVDVVEMHGTGTQAGDRVETHAVQSVFAPSNGNQREKPLIVGALKANIGHSEAAAGIISLMKAILILQHDKIPAQPNQPIKMNPYLEPLIGKQIQLANGQSWTRNGAEPRYIFVNNFDAAGGNVSMLLQDPPAFALPAPASGPGLRTHHVVVTSGRTATAHEANRKRLHAYLSAHPDTNLADLAYTTTARRIHNVHREAYVASSTSDLVRQLEKPLADKVESAPPPAVVFTFTGQGAQSLGMGGALYSTSPTFRRLLDSLQSICEVQGLPTKFLNAIRGSGAEGATVTEVDMQVATVALEIALARYWRSLGIRPTVLIGHSLGEYAALCVAGVLSASDALALAFRRATLIFTRCPPSEAAMLAVGLPMRTVQYRIRDSAATTGCEVCCVNGPSSTVVGGPVAAIQALDEYLKSDGKVSTTRLRVQHAFHTRQMDVLLDELEASAAQVPFHAPTLPVASTVLGRIVRPGEQGVFDANYLRRHTREPVAFLDAVRACETEGLIPDRSFAVEIGPHPICISLMATCLQSAKINAWPSLRRGGDDWQSVSSTLAAAHSAQLPVAWSEFHKDHLDTVRLISDLPTYAFDLKTFWHSYKTPAAAVSAASATPSTTGLSRLASTTLHAVEKLQREEGKILGTFTVDLSDPKLAKAICGHVVDESAICPASIFIDMAYTAAVFLEQENGAGAALNTYELSSLEMHSPLVLREDIEVLPQVWVEAVLDIKSNAVSVHFKGQTSKGAVGYGSATMRLGQPDSAVRRDWSRIQSLVRARVQTLNRSVRPREVHAMDTALFYKVFSEIVDYSAPYHAVQEAVIAADFHDAAVTLQLTPTADLGTFTSSPFAVDALVHVAGFLLNADVRRPKNEVHIANHIGSLRIVGDLSSPGPYHVYATIREQDQKAGTSLCDVYTTDSQDRLVAVCSDICFKKLERDFFALLTGATRGRSTKPVAAAPAKSMAKRARQLAPSPSPSSSSGSNTPMSRSPTPSSVSDMVDLGTELLQAVAEQTGVSVAEMKSSPGTTFTEFGVDSQMAISILANFQRTTAVELPAAFFTNFPTPADAEAELGGSALDDLEEDITKPTPSPEQTQARKQGPAPSQHLLSLVAQALGLEASDLTPSTTFDSVGMDSMLSIKITAAFHAKTGIELPAAFFSANPTVGAAQEALDDDAEEESAPAQTSTNPAKETTIDSSRQHKLDAAVSRASYIHLKALPKGRRIYALESPFLEQPELFDLSIEEMATIFLRTIRRIQPHGPYLIGGWSAGSMYAYEVAHRLTREGETIQALIILDMRAPSLIPTSIVTTDFVDKLGTFEGINRARDLPEDLSVKERAHLMATCRALSRYDAPAFPSDRQPKQVAVVWALLGLDNRPDAPIASMGRPGLDIGKSMYEMNLDEFERYFNSWFYGRRQQFGTNGWEDLLGDHIAVYTVNGDHFSMMCPPYASEVGDIVIETVTRAVE
Protein: Uncharacterized protein Rv1319c (P9WQ31)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- cAMP/cGMP dual specificity phosphodiesterase Rv0805
- Pyruvate kinase
- Nucleoside diphosphate kinase
- Bifunctional
- GTP 3',8-cyclase 1
- GTP 3',8-cyclase 2
- Riboflavin biosynthesis protein RibBA
- 3,4-dihydroxy-2-butanone-4-phosphate synthase
- GTP cyclohydrolase 1
- CRP-like cAMP-activated global transcriptional regulator
Sequence:
MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT
Protein: Myo-inositol transporter 3C (J9VX18)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Function: Major transporter for myo-inositol. Plays a role in the traversal of the host blood-brain barrier.
Subcellular location: Cell membrane {ECO:0000305|PubMed:21398509}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSRTPSSLDKDKGSSEFVENMNEIEIIEHTRVPSDKPSGFGGHLIDENLVKVEGEDKVTPYLCFLISASAIAGFLFGYDTGVVGVALPLVGTDLGGSVLSSSQQEIITAGTTIGAIFGSAILGGWGDRLGRKVAILIADVFFTVGAVLIAASYSVPQMIVGRIVLGVGVGGAAAIAPLFITETAPTAVRGRCIGVNAFFIPFGQVISEAIGAGVQDMKNGWRLLFALGAVPSLFQLILFHYLPESPRILILRGQTDRARHVFSRIYPNATPEMIDYKFRVAQEYVTATTVLQSGTTYWQRTKTLFTKGSYRRSIVTVSLIQMAGQLSGFNTLLYYAGTLFSLLGLTNPALGGLIPAGTNAFFVLVGMTLVDKVGRRGLLMFGVPIMLAGLVWNIVAFHYLCIPTGGLLDTSYKYDTKLVGIVIGGIVFFTTGFGLTYSHLAWYQSEFLALEVRSVGSGIATTANWVANLVVSVSYLTELETLTPSGTYGLYLGFSVVFFIFAVFCYPETKQLSIDETSLLFEEDWGVKRSREMRRERRETQRRLADSEMTEVATAHVQAQKQKDSAVTRSELDNFMEELKNGAKRFPISR
Protein: Connectin (Q01819)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cell adhesion protein involved in target recognition during neuromuscular development. Mediates homophilic cellular adhesion.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Fasciclin-2
Sequence:
MATLADSAICFLLLSLLLIGACLVTPTEGRAKDDRRTRGRGSSSGVLSSSSSSSNNMNNGYYSGSSSTAGSSSGYVFTSSSAVNSGSTGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHCTLQEPKLSHFVDPVPPTILDVLNIGGFTAIGSNSASMGGVGNSVVGSSYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAVAPAHKRYDYYDDNNGGMSLGHGLDLDDNLSLHKQGFYGAGSPVVGHNDVDVLMTSHSASGDALDILTTKNAIYIKLFLLKPEMLPCHDELSDPTELPLSRDLMDVRSNVGQDMSTAGANSLAQGMTIIVSLVALMMISRG
Protein: Membrane associated histidine-rich protein 2 (Q8IDG8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MQPCPYDVYNQINHVGTHWAQHLGEHLHHLAHMHQHTPHVHHHIPHVHTLAHDRPCMPITAFFCRHHEHCSSHLMLIFLLLAFFLVVVYRLYNEVVNSAKTVRIVNITPVNEEHKAEASKEQSKSTSDSSTSTQQTL
Protein: Uroporphyrinogen decarboxylase (EC 4.1.1.37) (A0A494C085)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Protein: Heme oxygenase (EC 1.14.14.18) (Q9VGJ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ferrochelatase, mitochondrial
- Frataxin homolog, mitochondrial
- Holocytochrome c-type synthase
- Protoheme IX farnesyltransferase, mitochondrial
- Polycomb group protein Pc
- Histone H3
- Histone H3.3A
- Homeobox protein abdominal-B
- ENL/AF9-related, isoform B
- NADPH--cytochrome P450 reductase
Sequence:
MSASEETIADSQVSENVEDVEFVDMAFTKELRKATKDVHNLTDVLVNAKIALALSDDEVWYDGLLAFYELYKFFETHLPERLLPKEFHRTAAFERDFAYFYGSDWRKDYEIRPAVQKYLEHLEKIAAQNELLLFAYSYQMYMALMSGGQMLQKKRMIARKMWIFSKNDDEEQQKQADKEAELATARAADGSVDKDDLEARPMPAQVTICPPGCEATYFPEKISVLKAKLRRVFNNHYGAFDDDLRAAFIEESRNVFRLNIEVVRTIKGVNRANLRKLALALIFVSSIVVAVKFALK
Protein: Tryptophan 2-halogenase (EC 1.14.14.-) (Q0VZ69)
Organism: Chondromyces crocatus
Function: Involved in the incorporation of a chlorinated tryptophan residue into halogenated forms of the secondary metabolites called chondramides.
Interaction partners:
- Electron-transferring-flavoprotein dehydrogenase
- Acyl carrier protein
- FAD-binding domain-containing protein
Sequence:
MQLPSSTKILVVGGGPAGSTAATLLAREGFEVTLVEKAIFPRYHIGESLLISVQPIIDLLGAREAVEAHGFQRKKGVLWEWGGERWLFDWKKLRYDYTFHVKREEFDEILLRNAQKNGVKVFEGIDISRLEFDGERPVAAKWSKSSTGESGTIQFEFLLDASGRAGLMATQYLRSRMFMKAFQNVATWGYWKGATIPEVEVEGPITVGSIPYGWIWGIPLRDQTMSVGLVIHQELFKEKRATQSVEEIYHEGLKASPLFQDVVLKGATLEPQIRTETDYSYISRTLAGPGFFLVGDSGAFIDPLLSSGVHLAMHSALLAAASVKSIIAGEVDMASATEFYQRCYQGHFLRWALIVASFYEVNARKETYFWTAQQLAHEELGVFNMSQADMKDVFATMVSGVVDLGDAQNAGRLQKGAERVHQYLDDDGREEDVTALLQKSKQRIFEYLDRVKNRDSRAAMQRYKAGGTETFSMGLDADGAVGGLYVTTEPRLGLLRKVVEERAEAATEAPAPAAPPPAVAEV
Protein: Prolactin-2C3 (Mitogen-regulated protein 2) (Mitogen-regulated protein 3) (Prolactin-2C4) (Proliferin-2) (Proliferin-3) (P04768)
Organism: Mus musculus (Mouse)
Function: May have a role in embryonic development. It is likely to provide a growth stimulus to target cells in maternal and fetal tissues during the development of the embryo at mid-gestation. May play a role during wound healing and in the hair follicle cycle as a growth factor and/or an angiogenesis factor. May play a role in microvilli formation and cell proliferation of neuroblastoma cells.
Subcellular location: Secreted {ECO:0000269|PubMed:10537154, ECO:0000269|PubMed:16876275}. Endoplasmic reticulum {ECO:0000269|PubMed:16876275}.
Interaction partners:
- ATP-binding cassette sub-family C member 5
- Bile salt export pump
- Hepatic sodium/bile acid cotransporter
- Solute carrier organic anion transporter family member 1B2
- ATP-binding cassette sub-family C member 3
- ATP-binding cassette sub-family C member 2
- Organic solute transporter subunit alpha
- Solute carrier organic anion transporter family member 1A4
- ATP-binding cassette sub-family C member 6
Sequence:
MLPSSIQPCSWILLLLLVNSSLLWKNVASFPMCAMRNGRCFMSFEDTFELAGSLSHNISIEVSELFNEFEKHYSNVSGLRDKSPMRCNTSFLPTPENKEQARLTHYAALLKSGAMILDAWESPLDDLVSELSTIKNVPDIIISKATDIKKKINAVRNGVNALMSTMLQNGDEEKKNPAWFLQSDNEDARIHSLYGMISCLDNDFKKVDIYLNVLKCYMLKIDNC
Protein: Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) (P61289)
Organism: Homo sapiens (Human)
Function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition.
Subcellular location: Nucleus {ECO:0000269|PubMed:10657252, ECO:0000269|PubMed:12629132}. Cytoplasm {ECO:0000250}. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.
Interaction partners:
- Proteasome activator complex subunit 1
- 26S proteasome non-ATPase regulatory subunit 14
- PSME3-interacting protein
- Nuclear receptor coactivator 3
- Interferon gamma
- Proteasome activator complex subunit 2
- Tumor necrosis factor
- 26S proteasome non-ATPase regulatory subunit 8
- Retinoic acid receptor RXR-alpha
- Proteasome subunit alpha type-5
Sequence:
MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
Protein: Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (P04627)
Organism: Mus musculus (Mouse)
Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).
Interaction partners:
- GTPase KRas
- GTPase HRas
- GTPase NRas
- 14-3-3 protein zeta/delta
- Serine/threonine-protein kinase B-raf
- 14-3-3 protein beta/alpha
- Ras-related protein Rap-1A
- Dual specificity mitogen-activated protein kinase kinase 1
- Dual specificity mitogen-activated protein kinase kinase 2
- 14-3-3 protein eta
Sequence:
MEPPRGPPVSGAEPSRAVGTVKVYLPNKQRTVVTVREGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEAPSNLSVNELLTPQGPSPFTQQRDQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTDAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPSEQRERKSLADEKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
Protein: DNA primase large subunit (D7SFP4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MIEDLEAACQFNLFEAPNKTFYKVDFIDAIELIRRGSVHLKKGFAYFPFDDLVTILVTKMKNNMMAAMARSFKHLAILEEEGRLLPRLSLLSNNAYSGKDYNGEQPDGSIIVTRHMIDKLSRRSFAPCMKQMHNHLRVNHHLKYGARRQYGLFLKGIGLSLDEAIAMMRDEFTKKITSDKFDKEYGYNIRYMYGKEGRRVAQTAMSCATIILRNPPSAVDCHGCPFRHSEKQVLKQKLGSDAILKKEQIERIAELAELNQYDKACTRYFEFMHNLEEGGLGQLITHPNQFYEESQKIVAERIAAKQESQEAPAPKIEKMDTE
Protein: Myocyte enhancer factor 2C (D8L7E9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
Protein: RCG61099, isoform CRA_c (Q0ZFS8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Serine/arginine-rich splicing factor 7
- Transformer-2 protein homolog beta
- YTH domain-containing protein 1
- Serine/arginine-rich splicing factor 1
- Nuclear RNA export factor 1
- Serine/arginine-rich splicing factor 2
- RNA-binding protein 8A
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Eukaryotic initiation factor 4A-III
- SRSF protein kinase 1
Sequence:
MHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWGRRPRDDYRRRSPPPRRRSPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK
Protein: Large ribosomal subunit protein uL23m (39S ribosomal protein L23, mitochondrial) (L23mt) (MRP-L23) (Q9W021)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q16540}.
Interaction partners:
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein mL41
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL30m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS2m
Sequence:
MSTRWYPIYQRGNPQLRVFLPNFWMKLIRPTEEQPPNVVTFSVSMEMTKYDVRNYLEKIYKLPVVDVRTRIAMGETKKDQTYGYITKKDDVKLAYVTLPREESFVFPDFFSEKAEKQAKEEKSLDESKAGFRRFLDRNKKRPGTPGWFSI
Protein: Uncharacterized ATP-dependent helicase IRC20 (EC 3.6.1.-) (Increased recombination centers protein 20) (Q06554)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Is probably involved in a pathway contributing to genomic integrity.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Postreplication repair E3 ubiquitin-protein ligase RAD18
- Histone H4
Sequence:
MSAVGALLAREYNVTAEKCDFFLENGSFDSVIAALPALNQEQETVTQKVSKNGKELINVASVNIEIPERISLSNNGRQLFKFIVDIEILPCENDNEATLVVSSDSVSLFQIGFKMENNSKIAVDKQLPLILDICAHKNQERALRNQLENRKSLERKPSRKRRKKNSNVNDPEKLLKSRIHELSLSYKDFECSPVVFRYNDSSLTWVLSFNLKLKFLNNKFNRFSVEANQILDLTFSNRDENEFERYHKHSHIHSNFIQKQFISQILEYSKDRLSKIKPFLPQSIPDLKVNLLPFQRESVEWMLIKEGHGNSLSDTPTVIDEVGLIDFMNEYYAYGYELIARSPDEVGPSLLWNKLTGYILTTEDAAHLYNQYRKERLSGDYPVCAKGVLAEEMGLGKTIEILSLILLNRRKLKDSEATFIDDENRTITKTKTTLIICPNAILKQWLEEIELHANSLKWYTYRGYNEIMKDCKTVDEAVQQLCQYDIIVTSYNIIATEVHHAEFNRSIRSRRLKSPKYDYSSPLALMQFYRIILDEVQMLRSSSTYSAKCTSLLHRIHTWGVSGTPIQNIYNFRMIMSYLKLHPFCDEVDFIRTLQEEIKLRNEAKDYTSNDFVCQLKGVRFSIKDCMNIFYRYDLCIRHSKANVASQIHIPRQHNFIIPLEFAPIEWDNYLNLWNNFLELSGYNSDGSGSPRVSNAFLNEWLSRLRYICCHALFPEILSTRQKRLHGHLSRISNIDDILISMRMDAFDSLIGYYRERFHLSIKQAQYELEISNTPAKALESFIKIRDDLMIHIRQKFNVEDPFDKSLNLSEDEDEHMDERFGEKETSSGDESDREINGAKNHDNHNNDGMLSNHLKKKGLRAMMNLLHDCYFFLGSVYYNLGTRKLEEADDKHRKEKTEEVVYSDVFPKNELEEIEENRLLEQENYANAEILRKSILSSEARKVDMTIKMARTKFAPMTSNIPLRLINIEFDHKNDYSSNLAVSRCFKSLSKLIEGLNEQTKNFNELLDELLIIIYEPVHRTEDDDSTNKIIGNEEYSTSIDSQDKIFSLLGCLEIILQNRDNILTSESEVKIPKHLVPEGSIISKYQKQLLNSLRLISGTPLRTVFDELKNSRIVRRISSSNESESTIQNFEDYLLQYEVESKSLFKYNKQVRESLKILGSIYNAKTEYYSQLQRISDSLVSLHSLSAPQLSHLIRTINKSLGGTLDAKINNIESRLIYLKNLSRLKDTLNDNQILSCSICLGEVEIGAIIKCGHYFCKSCILTWLRAHSKCPICKGFCSISEVYNFKFKNSTEKREKEIQEPRREGADSSQDNSNENSIISNMSEVEKLFGNKYEQFHQINEVHQIHIKESFGAKIDFVIKLISYLRLKSEQENADPPQVILYSQKTEYLKVIGKVLKLYHIEHLACLSNTANVGETINNFKRQPSVTCLLLNVKTLGAGLNLINAKHIFLLDPILNNSDELQAMGRNNRIGQDEETFVWNFMIRNTVEENILRYKCILEERKRKEKSKKGDKYDEAQDETDNEESDDAKFEISVVDQEVSNEHLWNCFFHGSD
Protein: Stathmin (Q96CE4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDFSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKESKDPADETEAD
Protein: Gonadotropin-releasing hormone receptor-2 (B9P4N4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MNTTQLIEDLLQNSSCKHEAKHLNSNIAGDLPHPLHLPRFTAASQVRVTLTLVLCALSACCNLAVLYSANNNQRKRSHVRLIITNLAAADLLVTFVVMPTDAVWNITLQWRAGDLACRTLMFLKLVAMYSCAFVTVVISLDRQAAILNPLSINKAMRRNKVLLGVAWTMSVVLSIPQVFVFHVVEIDSPKQFVQCTTYGSFSSRWQETFYNMFTFTFLFLLPLFIMISCYTRILFEISKKMTEDRLLSNKVQLRRSKNNIPKARMRTLKMTVVIVLSFMVCWTPYYMLGLWYWFSPAGLEETVSQSLSHILFIFGLLNACLDPIIYGLFTVPLCRGMRHRQREQNIVAFELENTNNSLMTSIRTSTSPLTLKRLAVQQTSREKLEWDAEFVLKTGDDGTKNALYSSGVATVE
Protein: Ethanol sensitive with low memory, isoform A (Ethanol sensitive with low memory, isoform B) (Q9VNF9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Anchor, isoform B
- polynucleotide adenylyltransferase
Sequence:
MGNKSSLFLRNEEIAQIQEETGFTPNQIERLYSRFTSLDRNDCGTLSREDLMRIPELAINPLCERIVHSFFAESNDDRVNFRQFMNVLAHFRPLRDNKQSKLNSREEKLKFAFKMYDLDDDGVISRDELLSILHMMVGANISQDQLVSIAERTILEADLCCQGKISFEDFCKALDRTDVDQKMSIRFLN