wanglab/gogpt-training-data huggingface dataset:
Protein: Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p38 subunit) (Q9C5Z2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Regulates translation initiation of specific 5' mRNAs harboring multiple upstream open reading frames (uORFs) in their 5' leader sequence (e.g. BETA-OHASE 2 and LHY).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit C
Sequence:
MATMARSFLQAISKDEAVAPPLRVVQIEGLAVLKIIKHCKEFSPTLVTGQLLGLDVGSVLEVTNCFPFPVRDDDEEIEADGANYQLEMMRCLREVNVDNNTVGWYQSTVLGSYQTVELIETFMNYQENIKRCVCIIYDPSKADLGVLALKALKLSDSFMELYRGGNFTGEKLREKNFSWMDIFEEIPIKVSNSALVSAFMTELETDTPVSQGDYDRLHSSTTPFLENNMEFLIKCMDDLSMEQQKFQYYYRNLSRQQAQQQAWLQKRRTENMARKSAGEEPLPEEDPSNPIFKAIPEPSRLESFLITNQVSNFCGQINGVAGQNFSRLYLTKALHDN
Protein: T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (Q3ZBH0)
Organism: Bos taurus (Bovine)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P78371}.
Interaction partners:
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit zeta
- Uncharacterized protein
- T-complex protein 1 subunit zeta-2
- T-complex protein 1 subunit theta
Sequence:
MASLSLAPVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAARQALLNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLASRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGKTTAGLDMKEGTIGDMSVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC
Protein: Transcription initiation factor IIE subunit beta (TFIIE-beta) (Factor A 43 kDa subunit) (Transcription factor A small subunit) (P36145)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- General transcription and DNA repair factor IIH subunit SSL1
- General transcription and DNA repair factor IIH subunit TFB2
- General transcription and DNA repair factor IIH subunit TFB5
- Transcription initiation factor IIF subunit alpha
- General transcription and DNA repair factor IIH subunit TFB1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- Serine/threonine-protein kinase KIN28
- Transcription initiation factor IIE subunit alpha
- General transcription and DNA repair factor IIH helicase subunit XPD/RAD3
- Transcription initiation factor IIF subunit beta
Sequence:
MSKNRDPLLANLNAFKSKVKSAPVIAPAKVGQKKTNDTVITIDGNTRKRTASERAQENTLNSAKNPVLVDIKKEAGSNSSNAISLDDDDDDEDFGSSPSKKVRPGSIAAAALQANQTDISKSHDSSKLLWATEYIQKKGKPVLVNELLDYLSMKKDDKVIELLKKLDRIEFDPKKGTFKYLSTYDVHSPSELLKLLRSQVTFKGISCKDLKDGWPQCDETINQLEEDSKILVLRTKKDKTPRYVWYNSGGNLKCIDEEFVKMWENVQLPQFAELPRKLQDLGLKPASVDPATIKRQTKRVEVKKKRQRKGKITNTHMTGILKDYSHRV
Protein: Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) (E9PY46)
Organism: Mus musculus (Mouse)
Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (By similarity). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22282595, ECO:0000269|PubMed:24009529, ECO:0000269|PubMed:24619649}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96RY7}. Cell projection, cilium {ECO:0000269|PubMed:22282595, ECO:0000269|PubMed:24009529, ECO:0000269|PubMed:24619649}.
Interaction partners:
- Tetratricopeptide repeat protein 21B
- Intraflagellar transport protein 43 homolog
- WD repeat-containing protein 19
- Intraflagellar transport protein 122 homolog
- WD repeat-containing protein 35
- Intraflagellar transport protein 80 homolog
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 172 homolog
Sequence:
MALYFDHRIKAPDTPSSPSHITWHPTHPFLAVASISPSSGGNVDIYLEQGEPVPDTHIERSFQATSLCWHPTRLILAIGWETGEVIMFNKQDKEQHTVPLPHTTDIAILSWSTSGSCLVSGDKLGVLLLWRLDQRGRVQGTPLLKHEYGKALTHCIFRLPPPGEDLVQLAKAAVSGDEKALDMFNWRKSSFGSFLKTGSQEGLSFFVSLMDGTVHYVDEKGKTAQVASTDSSIQTLFYIERREALVVVTENLLLSLYVVTPEGEAEEVMKVKLSGKTGCRADITLIEGSLLVTAIGEPVLRFWDLERGENYILSLQEKFGFEKGESINCVCFCKAKGLLAAGTNKGRVAMWKKVPSFPNGRGAEGKDMWALQTPTELEGNITQIKWGSRKNLLAVSSTESVSILSEQAMSSHFHQQVAAVQISPSLVNVSFLSTGGTHSLHTDMHISGVFATKDAVAVWNGKQVAIFEPSGSTLRNAGTFLCETSVLAMHEESIYTVEPNRLQVRTWQGTVKQLLLFSETEGSPCFLDVCGTFLVAGTDLAHFKSFDLSRREAKVHCSCKNLAQLVPDVGSITSLRCNANGNKISILLSKVNNSPDSKIYIYDVEMDTVNVFNFTTGQIGQIQTLPFNEPPTNETRSFMDKSLAGYTPVNHFWDQSEPRLFVCEALQEAPGAQPQAVDKQPRVEEGTCHKEEVLILSFFASEEHGFLLHDSFPRPSTYQSLLGMEVPHYYFTKKPGEADKEDRVDSGYYHIPQMVAKRPLRDFVGLEDCDKSTRDAMLNFSFFVTIGDMDEAFKSIKLIKSEAVWENMARMCVKTQRLDVAKVCLGNMGHARGARALREAEQEPELEARVAMLAIQLGMLEEAEQLYKKCKRYDLLNKFYQASDQWQKAVEVAELHDRVHLRTTYYNYAKHLEASADCGQALSYYEKSDTHRFEVPRMLSEDLQSLELYINRMKDKTLWRWWAQYLESQAEMDTALRYYELAQDYFSLVRIHCFQGNIQKAAEIANETGDWAASYHLARQYESQDEVKQAVHFYTRAQAFNNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEEKGEQMDRAVMLYHKAGHFSKALELAFTTQQFAALQLIAEDLDEKSDPALLARCSDFCIEHRQFEKAVELLLAAKKYHEALQLCLEQNMTITEDMAEKMTVSKDSKDMSEESRRELLEQIANCCMRQGNYHLATKKYTQAGNKLKAMRALLKSGDTEKIVFFAGVSRQKEIYIMAANYLQSLDWRKEPEIMKSIISFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLSKAKTKNPLDQETKLAQLQSKMTLVKRFIQARRTYTEDPKESLRQCELLLEEPDLDSTIRVGDVYGFLVEHHVQMEEYQMAYKYLEEMRKRLPSANMSYYVDQRTVDTVHQGLGLLPPSRIMPERVRHNSMEDHKEVYEEVIEEVDNDP
Protein: LD28992p (Q8MSV7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQIKSGGKSKSRPDFPELPGAVTAVAASGGAANQATVVSSQNTPPSSSSSISYSQSLNATPPSSSSDAESTNSPELLAQVQIPAYSMITPTLTASMISSVSSSVASTSSTSCSPPALQKSKSVEHDTSYSCNSSNLDQQYPALEKTVKRHSTNNVSVAVAASTSASASSSLYNFAAAAKQQLTENTHSAVSPPAAVTTTSTAVAASAPAPTTVTVPAAVTVPCYSSSSTHGSTQTSTSTASSAIAALPSGKAKAKPKELSPSSSCSKKPTKPSQDVPSISLSISTTPRATTSTSTTTTQKTTAATQTEGAKKLIGGIHKLPSSSCIAKGAGAVLEATAGRRAVIILNDDREAGRSNNEFIFGDFNEDELKLFDDNLDDEEEGQHKQSSNKKQQTEGESDVTQDDTEDVDQDLDKELECLGRRPEKKQERQQDISASSDQHLNDSGAASDAVNSSASLDMLSISAEAAQSSPNAGATATSSSVASPINSSTPSGASSASASTSTSSSSVSISSSSGGNGAACLASVSGMLGGVANQSGDSGIYAAANTSIKEHVNTFLSKASSSEETLPSPNSISMQQLETCNDIEAAIIAAARAAAAARSTSCSRSNSQEQDALQPQVKTKATPNPEAKMVLPVFVTYNNNNNDDDDDEEDDESLQELSFMADLKADAATEDIAMQPPPPSCPAMMTNTELIVDYIAKTWNAIANSKYVTYYNEQEQEQET
Protein: IKAROS family zinc finger 4 (F8VPL6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTAVPLTSRNPRFLEGSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSRLLGPDERLLEKDDSVIVEDSLSEPLGYCDGSGPEPHSPGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQSLSTEAQALAGQPGDEIRDLEMVPDSMLHSSSERPTFIDRLANSLTKRKRSTPQKFVGEKQMRFSLSDLPYDVNSGGYEKDVELVAHHSLEPGFGSSLAFVGAEHLRPLRLPPTNCISELTPVISSVYTQMQPLPGRLELPGSREAGEGPEDLADGGPLLYRPRGPLTDPGASPSNGCQDSTDTESNHEDRVAGVVSLPQGPPPQPPPTIVVGRHSPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAFKCEHCRILFLDHVMFTIHMGCHGFRDPFECNICGYHSQDRYEFSSHIVRGEHKVG
Protein: Ethylene-responsive transcription factor 1B (AtERF1B) (Ethylene-responsive element-binding factor 1B) (EREBP-1B) (Q8LDC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression during the plant development, and/or mediated by stress factors and by components of stress signal transduction pathways. Seems to be a key integrator of ethylene and jasmonate signals in the regulation of ethylene/jasmonate-dependent defenses. Can mediate resistance to necrotizing fungi (Botrytis cinerea and Plectosphaerella cucumerina) and to soil borne fungi (Fusarium oxysporum conglutinans and Fusiarium oxysporum lycopersici), but probably not to necrotizing bacteria (Pseudomonas syringae tomato).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein ETHYLENE INSENSITIVE 3
- ETHYLENE INSENSITIVE 3-like 1 protein
- ETHYLENE INSENSITIVE 3-like 3 protein
- Ethylene-responsive transcription factor 2
- ETHYLENE INSENSITIVE 3-like 2 protein
- ETHYLENE INSENSITIVE 3-like 5 protein
- Putative ETHYLENE INSENSITIVE 3-like 4 protein
- Ethylene-insensitive protein 2
- Defensin-like protein 16
- Transcription factor MYC2
Sequence:
MDPFLIQSPFSGFSPEYSIGSSPDSFSSSSSNNYSLPFNENDSEEMFLYGLIEQSTQQTYIDSDSQDLPIKSVSSRKSEKSYRGVRRRPWGKFAAEIRDSTRNGIRVWLGTFESAEEAALAYDQAAFSMRGSSAILNFSAERVQESLSEIKYTYEDGCSPVVALKRKHSMRRRMTNKKTKDSDFDHRSVKLDNVVVFEDLGEQYLEELLGSSENSGTW
Protein: Collagen alpha-1(VI) chain (Q04857)
Organism: Mus musculus (Mouse)
Function: Collagen VI acts as a cell-binding protein.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Collagen alpha-2
- von Willebrand factor A domain-containing protein 1
- Collagen alpha-1
- Collagen alpha-1
- CD44 antigen
- Integrin alpha-5
- Collagen alpha-2
- Platelet glycoprotein VI
- Collagen alpha-2
- Collagen alpha-1
Sequence:
MRLAHALLPLLLQACWVATQDIQGSKAIAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIRGLTRMPSGRDELKASVDAVKYFGKGTYTDCAIKKGLEELLIGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGHSRDAEEVISQTIDTIVDMIKNNVEQVCCSFECQAARGPPGPRGDPGYEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGMKGETGYPGLPGCKGSPGFDGIQGPPGPKGDAGAFGMKGEKGEAGADGEAGRPGNSGSPGDEGDPGEPGPPGEKGEAGDEGNAGPDGAPGERGGPGERGPRGTPGVRGPRGDPGEAGPQGDQGREGPVGIPGDSGEAGPIGPKGYRGDEGPPGPEGLRGAPGPVGPPGDPGLMGERGEDGPPGNGTEGFPGFPGYPGNRGPPGLNGTKGYPGLKGDEGEVGDPGEDNNDISPRGVKGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECTCGPIDILFVLDSSESIGLQNFEIAKDFIIKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDMRSPNVRNAQDFKEAVKKLQWMAGGTFTGEALQYTRDRLLPPTQNNRIALVITDGRSDTQRDTTPLSVLCGADIQVVSVGIKDVFGFVAGSDQLNVISCQGLSQGRPGISLVKENYAELLDDGFLKNITAQICIDKKCPDYTCPITFSSPADITILLDSSASVGSHNFETTKVFAKRLAERFLSAGRADPSQDVRVAVVQYSGQGQQQPGRAALQFLQNYTVLASSVDSMDFINDATDVNDALSYVTRFYREASSGATKKRVLLFSDGNSQGATAEAIEKAVQEAQRAGIEIFVVVVGPQVNEPHIRVLVTGKTAEYDVAFGERHLFRVPNYQALLRGVLYQTVSRKVALG
Protein: IP15857p (Uncharacterized protein, isoform C) (Uncharacterized protein, isoform D) (Uncharacterized protein, isoform E (EC 3.1.2.22)) (Uncharacterized protein, isoform F) (Uncharacterized protein, isoform G) (Q9VBX8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFSISELCCMFCCPPCPGPIAAKLAFQPPEPTYKLTPADDTNIRYNLQLFDRAEWQYSEREKSKVEAFFTRTSRGNLITCIYVRCSKNAKYTLLFSHGNAVDLGQMSSFYLTLGSQINCNIFGYDYSGYGMSGGKPSEKNLYADIEAAWQAMRTRFNISPETIILYGQSIGTVPTVDLASRHEVGAVILHSPLMSGLRVVFRNTKRTWFFDAFPSIDKVAKVKAPVLVIHGTDDEVIDFSHGIGIYERCPKTVEPFWVEGAGHNDVELHPHYYERLRKFLSVELVK
Protein: Onchocystatin (OV17) (Cysteine proteinase inhibitor OV7) (P22085)
Organism: Onchocerca volvulus
Function: Cysteine protease inhibitor which inhibits members of the peptidase C1 family. In the human host, inhibits CTSL/cathepsin L and CTSS/cathepsin S and to a lesser extent CTSB/cathepsin B which may cause defects in antigen processing and thereby impair antigen-driven T cell proliferation.
Interaction partners:
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
Sequence:
MLTIKDGTLLIHLLLFSVVALVQLQGAKSARAKNPSKMESKTGENQDRPVLLGGWEDRDPKDEEILELLPSILMKVNEQSNDEYHLMPIKLLKVSSQVVAGVKYKMDVQVARSQCKKSSNEKVDLTKCKKLEGHPEKVMTLEVWEKPWENFMRVEILGTKEV
Protein: IP10137p (Q9VAX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform E
- CG33306 protein
- SD22430p
- Seminal metalloprotease 1
Sequence:
MESGWTLVRLLLILNSVRTEAGNREEWTGRFHPRIYNGIKTTVESLGGVGIQLFNGRKLVCSATLLTPRHILTAAHCFENLNRSKFHVIGGKSAEFTWHGNNFNKNKLIRVQIHPKYAKMKFIADVAVAKTKYPLRSKYIGYAQLCRSVLHPRDKLIAAGWGFEGGVWDESRKKTFRSMKVGIVSKRDCEKQLDRKMPPNIICAGAYNNKTLCFGDSGGPLLLGRQVCGINTWTFKCGNNEKPDVYMGVRYYAKFIKRTINRMGF
Protein: Serine/threonine-protein kinase PknB (EC 2.7.11.1) (P9WI81)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates the proteolytic activity of the proteasome. Is a major regulator of the oxygen-dependent replication switch since PknB activity is necessary for reactivation of cells from the hypoxic state. Shows a strong preference for Thr versus Ser as the phosphoacceptor. Overexpression of PknB alters cell morphology and leads to cell death.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21829358}; Single-pass membrane protein {ECO:0000269|PubMed:21829358}. Note=Localizes to septum and cell poles (PubMed:21829358). The localization of PknB to the cell membrane is essential for cell survival (PubMed:24706757). {ECO:0000269|PubMed:21829358, ECO:0000269|PubMed:24706757}.
Interaction partners:
- Glycogen accumulation regulator GarA
- Serine/threonine protein phosphatase PstP
- FHA domain-containing protein FhaA
- Peptidoglycan D,D-transpeptidase PbpA
- Peptidoglycan glycosyltransferase RodA
- FHA domain-containing protein FhaB
- Serine/threonine-protein kinase PknA
- Cell wall synthesis protein Wag31
- ABC transporter ATP-binding/permease protein Rv1747
- FHA domain-containing protein
Sequence:
MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAITNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ
Protein: Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] (P14272)
Organism: Rattus norvegicus (Rat)
Function: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Subcellular location: Secreted.
Interaction partners:
- Kininogen-1
- Coagulation factor XII
- Plasma protease C1 inhibitor
- Plasminogen
- Alpha-2-macroglobulin
- Lysosomal Pro-X carboxypeptidase
- Coagulation factor XI
- Complement component 1 Q subcomponent-binding protein, mitochondrial
- B1 bradykinin receptor
- B2 bradykinin receptor
Sequence:
MILFKQVGYFVSLFATVSCGCLSQLYANTFFRGGDLAAIYTPDAQHCQKMCTFHPRCLLFSFLAVSPTKETDKRFGCFMKESITGTLPRIHRTGAISGHSLKQCGHQLSACHQDIYEGLDMRGSNFNISKTDSIEECQKLCTNNIHCQFFTYATKAFHRPEYRKSCLLKRSSSGTPTSIKPVDNLVSGFSLKSCALSEIGCPMDIFQHFAFADLNVSQVVTPDAFVCRTVCTFHPNCLFFTFYTNEWETESQRNVCFLKTSKSGRPSPPIIQENAVSGYSLFTCRKARPEPCHFKIYSGVAFEGEELNATFVQGADACQETCTKTIRCQFFTYSLLPQDCKAEGCKCSLRLSTDGSPTRITYEAQGSSGYSLRLCKVVESSDCTTKINARIVGGTNSSLGEWPWQVSLQVKLVSQNHMCGGSIIGRQWILTAAHCFDGIPYPDVWRIYGGILNLSEITNKTPFSSIKELIIHQKYKMSEGSYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYTNCWVTGWGYTKERGETQNILQKATIPLVPNEECQKKYRDYVITKQMICAGYKEGGIDACKGDSGGPLVCKHSGRWQLVGITSWGEGCARKEQPGVYTKVAEYIDWILEKIQSSKERALETSPA
Protein: Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B] (P06869)
Organism: Mus musculus (Mouse)
Function: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P00749}.
Interaction partners:
- Plasminogen activator inhibitor 1
- Urokinase plasminogen activator surface receptor
- Vitronectin
- Glia-derived nexin
- Plasminogen
- Cathepsin B
- Plasminogen activator inhibitor 2, macrophage
- Tissue-type plasminogen activator
- Plasma serine protease inhibitor
- Tissue factor
Sequence:
MKVWLASLFLCALVVKNSEGGSVLGAPDESNCGCQNGGVCVSYKYFSRIRRCSCPRKFQGEHCEIDASKTCYHGNGDSYRGKANTDTKGRPCLAWNAPAVLQKPYNAHRPDAISLGLGKHNYCRNPDNQKRPWCYVQIGLRQFVQECMVHDCSLSKKPSSSVDQQGFQCGQKALRPRFKIVGGEFTEVENQPWFAAIYQKNKGGSPPSFKCGGSLISPCWVASAAHCFIQLPKKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIALLKIRTSTGQCAQPSRSIQTICLPPRFTDAPFGSDCEITGFGKESESDYLYPKNLKMSVVKLVSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSGGPLICNIEGRPTLSGIVSWGRGCAEKNKPGVYTRVSHFLDWIQSHIGEEKGLAF
Protein: GSK-3-binding protein FRAT2 (Frequently rearranged in advanced T-cell lymphomas 2) (FRAT-2) (O75474)
Organism: Homo sapiens (Human)
Function: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.
Interaction partners:
- Glycogen synthase kinase-3 beta
- Proto-oncogene FRAT1
- Segment polarity protein dishevelled homolog DVL-3
- Segment polarity protein dishevelled homolog DVL-1
- Segment polarity protein dishevelled homolog DVL-2
- Catenin beta-1
Sequence:
MPCRREEEEEAGEEAEGEEEEDDSFLLLQQSVTLGSSGEVDRLVAQIGETLQLDAAQDSPASPCAPPGVPLRAPGPLAAAVPADKARPPAVPLLLPPASAETVGPAPSGALRCALGDRGRVRGRAAPYCVAEVAAGPSALPGPCRRGWLRDAVTSRRLQQRRWTQAGARAGDDDPHRLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPASAPGPGGGRSGPDRIALQPSGSLL
Protein: K Homology domain-containing protein (Q95R07)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKEEQIAYKLPGAWYYEEDTASCSPVSDPEDIAQFLNYRTSIGVQNVTESVEVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEDPIFVVTGRLEDVNEAKREIDCAAEHFTQIRASRRHTQVVPGAHAPGQITSYVRVPLRVVGLVVGPKGATIKRIQQDTHTYIITPSREREPVFEVTGLPHNVEAARKEIETHIFQRTGNLPETDNDFAGQLAGVSLMVQKQQQAQQQMQEAQQQSMFYRRAFGNSNPFNQKEMSSSPFGMESSLGLDALLRSFPSMRSSLTPESLSGTGLSSRPSLGGGQSAKQDLPTYDYWGTNNSLNDIMENEILSRKYDALSAWSSMGLEKREESPTNGLMSSLKGTSAGFGLLSTIWSGGNMNLSPGSLASASASPTSSTCDHNDHTLVPING
Protein: Transcriptional regulatory protein dep1 (Q9P7M1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Histone deacetylase clr6
- Transcriptional regulatory protein rxt2
- Putative histone deacetylase complex subunit cti6
- Chromatin modification-related protein png2
- Transcriptional regulatory protein sds3
- Transcriptional regulatory protein rxt3
- RbAp48-related WD40 repeat-containing protein prw1
- Paired amphipathic helix protein pst1
- Paired amphipathic helix protein pst3
- Paired amphipathic helix protein pst2
Sequence:
MTENLQSESIPHEILPKEPFDLPMNNLKSSPKNKDSEKRINNSIAESEQVVDSALSNPETNANEDIIAPQLPSQNSEIIEKNSPVNKLNSSTSLTTHQLASLPKLEVTDHDNVSEAETVVLNEDEEKETSLVGSVSVTEDLGDSSAIGRTILVNNSVEPQMENTANITIVSPSLKESDFESEEKATNDNNGLIETNHNSKLEESSEHEEEEDEESNIERTEDSDHQIPQRGGTLEAPRKGGPRSGVGSRKRKRATVSRKWSTNSESKIKRVALETSQEESDREIADRRSASEQAHEADDEKAIKRKEAFDALLNIETEFTFLRNRLYGKKLLKLNEHEEMIQNETHERFNACIDLITERRDDRVRLATENLMKQLGNIKNVMDYVTKQRKYQLLFDKRRIRQALLTKIATKCFQLLNKQKSVHDPTYITQKTMSYRQSALLQKQRIEYEAAVLCELNSFAGFPTAPIIETASFDDIRNDLLEMGCLSENQD
Protein: Flavin-dependent trigonelline monooxygenase, oxygenase component (EC 1.14.14.-) (Q6F9F6)
Organism: Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Function: Involved in the degradation of the pyridine ring of trigonelline (TG; N-methylnicotinate) into succinate and methylamine as carbon and nitrogen sources, respectively. Catalyzes the insertion of two oxygens, followed by a ring cleavage of trigonelline to yield (Z)-2-((N-methylformamido)methylene)-5-hydroxybutyrolactone (MFMB). It is able to use reduced FMN or FAD.
Interaction partners:
- Peptide synthetase
- Flavin-dependent trigonelline monooxygenase, reductase component
- (E)-2-((N-methylformamido)methylene)succinate hydrolase (MFMS hydrolase)
- (Z)-2-((N-methylformamido)methylene)-5-hydroxybutyrolactone dehydrogenase (MFMB dehydrogenase)
Sequence:
MRFSLFVHMERVSDQQTQKQLYDEMIELCQIADRGGMHAIWTGEHHAMNFTIAPNPFLNIADLANKTKHVRLGTGTVVAPFWHPIKLAGEAAMTDIISNGRLDIGIARGAYSFEYERMVPGMDAWSAGQRLREMIPAIKNLWKGDYEHNGEFWQFPKTTSAPQPLQQPNPPIWVAARDPNSHEFAVQNGCNVQVTPLHLGDEEVEKLMGHFNSACEKFQDIERPEIMLLRHTYVADSEEDAQVAANEMNVFYNYFGAWFKNEREINQGLIAPLSDEEIAAHPFYTPEAMRKNNVIGQAQEVIDRLKAYEAMGYDEYSFWIDTGMSFERKKASLERMINEVMPAFSESKVDRRHATISAVY
Protein: Intraflagellar transport protein 25 (Flagellar-associated protein 232) (B8LIX8)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Component of the intraflagellar transport (IFT) complex B. Forms a subcomplex within the IFT complex B with IFT27.
Subcellular location: Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum basal body. Note=Colocalizes with IFT27 at the distal-most portion of basal bodies, probably the transition zones, and concentrates in the basal body region.
Interaction partners:
Sequence:
MKDYAREENGGLVVMASCSDERFPPENMLDGKDNTFWVTTGMFPQEFVLRLESCIRVSKITTLSLNVRKLAVEKCDQDKPDQFEKVFEVELANRGDRLQTEVHQVNIRAKYLKFILLQGHGEFATVNRVSVVGGDDDGGGYDEPGGGYGSMQRQPSMGYGGGGGSAATGFAADPGNAAAGGGGGFEDEF