wanglab/gogpt-training-data huggingface dataset:
Protein: Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) (p170) (Q90240)
Organism: Anas platyrhynchos (Mallard) (Anas boschas)
Subcellular location: Cell membrane {ECO:0000269|PubMed:8138993}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAGAARGLLWAALSLCLLPEPLRAAHIKKAEAAAAGGGGGVGGELRYLHAAELGQALRDLVAEAPPGLARLFSIGRSVEGRPLWVLRLTAGLPELPEARQDGEKKKKEEEEEEEEEEGEEGGGGALPGRPQVKLVGNMHGDEPLARPLLLRLAQELVRGWAGGDERLGRLLNTTDLYLLPSLNPDGFERAREGDCGGGGGGGGEGGGEPGGRENSRGRDLNRSFPDQFGSAQPDLEPVPEVRALIAWMRRNKFLLSGNLHGGSVVASYPYDDSPTHRPTGVYSKSADDEVFKYLAKAYASHHPIMRTGKPNCPGEEGETFQDGITNGAQWYDVEGGMQDYNYVWANCFEITLELSCCKYPPTSELQQEWENNRESLLTFIEKVHIGVKGFVRDAITGAGLENATIVVAGIAHNITAGKFGDYHRLLVPGTYNVTAVVMGYAPVTKENIEVKEADATVVDFSLQPTVVAPDPNLTQFTATPAPPSTLTPSVAQVEPPATTSLHQAVQPVDFRHHHFSDMEIFLRRYANEYPSITRLYSVGKSVELRELYVMEISDNPGIHEAGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVQSTRIHIMPSMNPDGYEKSQEGDRGGTVGRNNSNNYDLNRNFPDQFFQVTDPPQPETLAVMSWLKTYPFVLSANLHGGSLVVNYPFDDDEQGIAIYSKSPDDAVFQQLALSYSKENKKMYQGSPCKDLYPTEYFPHGITNGAQWYNVPGGMQDWNYLNTNCFEVTIELGCVKYPKAEELPKYWEQNRRSLLQFIKQVHRGIWGFVLDATDGRGILNATISVADINHPVTTYKDGDYWRLLVQGTYKVTASARGYDPVTKTVEVDSKGGVQVNFTLSRTDAKVEEGKVPVLNTPDTSDPNEKEFETLIKDLSAENGLERLLLASSGKVSPYRYRPYKDLSEFLRGLYLNYPHITNLTSLGQSVEFRQIWSLEISNKPNHSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCMNYKKNSAVTKLIDRTRIVIVPSLNPDGREIAQERGCTSKLGHANAHGRDLDTDFTSNYSWYSGTREPETKAIIENLILKQDFSLSVALDGGSLLVTYPFDKPAQTVENKETLKHLASVYANNHPLMHLGQPGCPNKSDENIPGGVIRGSEWHSHLGSMKDFSVTFGHCPEITVYTSCCYFPSAGQLPGLWADHRKSLLSMLVEVHKGVHGFVQDKSGKAISKATIVLNEGLRVYTKEGGYFHVLLAPGLHNINAIADGYQQKHMKVLVRHDAPSSVFIVFDMENRIFGLPRELVVTVAGASMSALVLTACIIWCVCSIKSNRHKDGFPTLRQHHDDYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
Protein: Periplasmic oligopeptide-binding protein OppA (Polyamine-induced protein) (PI protein) (P23843)
Organism: Escherichia coli (strain K12)
Function: This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity.
Subcellular location: Periplasm {ECO:0000269|PubMed:2187863, ECO:0000269|PubMed:21983341}.
Interaction partners:
- Oligopeptide transport system permease protein OppC
- Oligopeptide transport ATP-binding protein OppF
- Oligopeptide transport ATP-binding protein OppD
- Oligopeptide transport system permease protein OppB
- Periplasmic murein peptide-binding protein MppA
- Dipeptide-binding protein
- Dipeptide transport ATP-binding protein DppF
- Glutamate/aspartate import solute-binding protein
- Dipeptide transport system permease protein DppB
- Dipeptide transport system permease protein DppC
Sequence:
MTNITKRSLVAAGVLAALMAGNVALAADVPAGVTLAEKQTLVRNNGSEVQSLDPHKIEGVPESNISRDLFEGLLVSDLDGHPAPGVAESWDNKDAKVWTFHLRKDAKWSDGTPVTAQDFVYSWQRSVDPNTASPYASYLQYGHIAGIDEILEGKKPITDLGVKAIDDHTLEVTLSEPVPYFYKLLVHPSTSPVPKAAIEKFGEKWTQPGNIVTNGAYTLKDWVVNERIVLERSPTYWNNAKTVINQVTYLPIASEVTDVNRYRSGEIDMTNNSMPIELFQKLKKEIPDEVHVDPYLCTYYYEINNQKPPFNDVRVRTALKLGMDRDIIVNKVKAQGNMPAYGYTPPYTDGAKLTQPEWFGWSQEKRNEEAKKLLAEAGYTADKPLTINLLYNTSDLHKKLAIAASSLWKKNIGVNVKLVNQEWKTFLDTRHQGTFDVARAGWCADYNEPTSFLNTMLSNSSMNTAHYKSPAFDSIMAETLKVTDEAQRTALYTKAEQQLDKDSAIVPVYYYVNARLVKPWVGGYTGKDPLDNTYTRNMYIVKH
Protein: Transcriptional activator DEMETER (EC 3.2.2.-) (DNA glycosylase-related protein DME) (Q8LK56)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator involved in gene imprinting. Catalyzes the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism. Allows the expression of the maternal copy of the imprinted MEA gene before fertilization, possibly by antagonizing or suppressing DNA methylation on target promoter. Probably acts by nicking the MEA promoter. Required for stable reproducible patterns of floral and vegetative development.
Subcellular location: Nucleus.
Interaction partners:
- DNA
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
- Homeobox-leucine zipper protein HDG6
- DNA
- DNA
- Histone-lysine N-methyltransferase MEDEA
- DNA
- ATP-dependent DNA helicase DDM1
- DNA-
- Increased DNA methylation 1
Sequence:
MNSRADPGDRYFRVPLENQTQQEFMGSWIPFTPKKPRSSLMVDERVINQDLNGFPGGEFVDRGFCNTGVDHNGVFDHGAHQGVTNLSMMINSLAGSHAQAWSNSERDLLGRSEVTSPLAPVIRNTTGNVEPVNGNFTSDVGMVNGPFTQSGTSQAGYNEFELDDLLNPDQMPFSFTSLLSGGDSLFKVRQYGPPACNKPLYNLNSPIRREAVGSVCESSFQYVPSTPSLFRTGEKTGFLEQIVTTTGHEIPEPKSDKSMQSIMDSSAVNATEATEQNDGSRQDVLEFDLNKTPQQKPSKRKRKFMPKVVVEGKPKRKPRKPAELPKVVVEGKPKRKPRKAATQEKVKSKETGSAKKKNLKESATKKPANVGDMSNKSPEVTLKSCRKALNFDLENPGDARQGDSESEIVQNSSGANSFSEIRDAIGGTNGSFLDSVSQIDKTNGLGAMNQPLEVSMGNQPDKLSTGAKLARDQQPDLLTRNQQCQFPVATQNTQFPMENQQAWLQMKNQLIGFPFGNQQPRMTIRNQQPCLAMGNQQPMYLIGTPRPALVSGNQQLGGPQGNKRPIFLNHQTCLPAGNQLYGSPTDMHQLVMSTGGQQHGLLIKNQQPGSLIRGQQPCVPLIDQQPATPKGFTHLNQMVATSMSSPGLRPHSQSQVPTTYLHVESVSRILNGTTGTCQRSRAPAYDSLQQDIHQGNKYILSHEISNGNGCKKALPQNSSLPTPIMAKLEEARGSKRQYHRAMGQTEKHDLNLAQQIAQSQDVERHNSSTCVEYLDAAKKTKIQKVVQENLHGMPPEVIEIEDDPTDGARKGKNTASISKGASKGNSSPVKKTAEKEKCIVPKTPAKKGRAGRKKSVPPPAHASEIQLWQPTPPKTPLSRSKPKGKGRKSIQDSGKARGPSGELLCQDSIAEIIYRMQNLYLGDKEREQEQNAMVLYKGDGALVPYESKKRKPRPKVDIDDETTRIWNLLMGKGDEKEGDEEKDKKKEKWWEEERRVFRGRADSFIARMHLVQGDRRFSPWKGSVVDSVIGVFLTQNVSDHLSSSAFMSLAARFPPKLSSSREDERNVRSVVVEDPEGCILNLNEIPSWQEKVQHPSDMEVSGVDSGSKEQLRDCSNSGIERFNFLEKSIQNLEEEVLSSQDSFDPAIFQSCGRVGSCSCSKSDAEFPTTRCETKTVSGTSQSVQTGSPNLSDEICLQGNERPHLYEGSGDVQKQETTNVAQKKPDLEKTMNWKDSVCFGQPRNDTNWQTTPSSSYEQCATRQPHVLDIEDFGMQGEGLGYSWMSISPRVDRVKNKNVPRRFFRQGGSVPREFTGQIIPSTPHELPGMGLSGSSSAVQEHQDDTQHNQQDEMNKASHLQKTFLDLLNSSEECLTRQSSTKQNITDGCLPRDRTAEDVVDPLSNNSSLQNILVESNSSNKEQTAVEYKETNATILREMKGTLADGKKPTSQWDSLRKDVEGNEGRQERNKNNMDSIDYEAIRRASISEISEAIKERGMNNMLAVRIKDFLERIVKDHGGIDLEWLRESPPDKAKDYLLSIRGLGLKSVECVRLLTLHNLAFPVDTNVGRIAVRMGWVPLQPLPESLQLHLLELYPVLESIQKFLWPRLCKLDQRTLYELHYQLITFGKVFCTKSRPNCNACPMRGECRHFASAYASARLALPAPEERSLTSATIPVPPESYPPVAIPMIELPLPLEKSLASGAPSNRENCEPIIEEPASPGQECTEITESDIEDAYYNEDPDEIPTIKLNIEQFGMTLREHMERNMELQEGDMSKALVALHPTTTSIPTPKLKNISRLRTEHQVYELPDSHRLLDGMDKREPDDPSPYLLAIWTPGETANSAQPPEQKCGGKASGKMCFDETCSECNSLREANSQTVRGTLLIPCRTAMRGSFPLNGTYFQVNELFADHESSLKPIDVPRDWIWDLPRRTVYFGTSVTSIFRGLSTEQIQFCFWKGFVCVRGFEQKTRAPRPLMARLHFPASKLKNNKT
Protein: DNA helicase (EC 3.6.4.12) (A0A2R8Y8C1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
LGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKELGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKGEEEVTAVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDGSQEDRGVCGRPRPPPMGRSTRAVGPAHLPSLPPDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPAEDGIKIEENSLKEEESIEGEKEVKSTAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEKAEVKERTEEPMETEPKGAADVEKVEEKSAIDL
Protein: WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) (Q9Y4P8)
Organism: Homo sapiens (Human)
Function: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane.
Subcellular location: Preautophagosomal structure membrane {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:23916833, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:33499712}; Peripheral membrane protein {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}; Cytoplasmic side {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. {ECO:0000269|PubMed:24954904}.
Interaction partners:
- Autophagy-related protein 16-1
- Ubiquitin-like protein ATG12
- Tectonin beta-propeller repeat-containing protein 1
- Autophagy protein 5
- Autophagy-related protein 2 homolog A
- Autophagy-related protein 2 homolog B
- WD repeat domain phosphoinositide-interacting protein 1
- Protein Atg16l2
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Serine/threonine-protein kinase ULK1
Sequence:
MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
Protein: Probable iron export ATP-binding protein FetA (EC 7.2.2.-) (P77279)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for energy coupling to the transport system.
Subcellular location: Cell inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Probable iron export permease protein FetB
- L-cystine transport system ATP-binding protein TcyN
- Multidrug resistance-like ATP-binding protein MdlB
- Glutathione/L-cysteine transport system ATP-binding/permease protein CydD
- Probable D,D-dipeptide transport ATP-binding protein DdpF
- Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP
- Protein QmcA
- Nickel import ATP-binding protein NikD
- Inner membrane protein YbbJ
Sequence:
MQENSPLLQLQNVGYLAGDAKILNNINFSLRAGEFKLITGPSGCGKSTLLKIVASLISPTSGTLLFEGEDVSTLKPEIYRQQVSYCAQTPTLFGDTVYDNLIFPWQIRNRQPDPAIFLDFLERFALPDSILTKNIAELSGGEKQRISLIRNLQFMPKVLLLDEITSALDESNKHNVNEMIHRYVREQNIAVLWVTHDKDEINHADKVITLQPHAGEMQEARYELA
Protein: Growth/differentiation factor 8 (GDF-8) (Myostatin) (Q68IN2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU369049}.
Interaction partners:
- Serine/threonine-protein kinase receptor
- receptor protein serine/threonine kinase
- Serine/threonine-protein kinase receptor
- Receptor protein serine/threonine kinase
- Receptor protein serine/threonine kinase
- Growth/differentiation factor 8
- Follistatin-A
- Major facilitator superfamily domain-containing protein 6-A
- Family with sequence similarity 207 member A
- Phosphoinositide phospholipase C
Sequence:
MFLLFYLSFWGVLGSQNQNLSTTTTTTTQAFVTPGDDNGQCTTCQFRQQSKLLRLHSIKSQILSILRLEQAPNISRDTVKLLLPKAPPLQELLDQYDQNGGISEDEEQASSETIITMATEPQAITQLVGMPKCCMFALSPKILPDSILKALLWIYLRPAEEPTTVYIQISHLESSSEGNNHSRIRAQKIDVNARTNSWQHIDMKQLLKLWLKQPQSNFGIEIKAFDANGNDLAVTSTESGEEGLQPFLEVKISDTGKRSRRDTGLDCDEHSTESRCCRYPLTVDFEDFGWDWIIAPKRYKANYCSGECVQKYPHSHIVNKANPRGSAGPCCTPTKMSPINMLYFNDREQIIYGKIPSMVVDLCGCS
Protein: Transcription factor SOX-12 (Q04890)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3'. Acts as a transcriptional activator. Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation. Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions. Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation. Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- Glycogen [starch] synthase, muscle
Sequence:
MVQQRGARAKRDGGPPPPGPGPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRASGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSGEGAAASAASPTLSEDEEPEEEEEEAATAEEGEEETVVSGEEPLGFLSRMPPGPAGLDCSALDRDPDLLPPSGTSHFEFPDYCTPEVTEMIAGDWRSSSIADLVFTY
Protein: Calmodulin-like protein 8 (AtCaM-8) (O23320)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- Probable calcium-binding protein CML46
- T14N5.3 protein)
- Putative cyclic nucleotide-gated ion channel 9
- At2g14110 superfamily protein)
Sequence:
MEETALTKDQITEFKEAFCLFDKDGDGCITVEELATVIRSLDQNPTEQELHDIITEIDSDSNGTIEFAEFLNLMAKKLQESDAEEELKEAFKVFDKDQNGYISASELSHVMINLGEKLTDEEVEQMIKEADLDGDGQVNYDEFVKMMINID
Protein: p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC] (Q9ERV7)
Organism: Mus musculus (Mouse)
Function: Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis. Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9HB75}. Nucleus {ECO:0000250|UniProtKB:Q9HB75}. Note=Enriched in the nucleus upon DNA damage. {ECO:0000250|UniProtKB:Q9HB75}.
Interaction partners:
- Death domain-containing protein CRADD
- Caspase-2
- BH3-interacting domain death agonist
- Serine-protein kinase ATM
- Tumor necrosis factor receptor superfamily member 10B
- FAS-associated death domain protein
- Cellular tumor antigen p53
- Receptor-interacting serine/threonine-protein kinase 1
Sequence:
MAAVLEGQEPEETAAAAEDAATSTLEAVDAGPGAPFLPAGNQLNLDLRPGGCHRLQYLCSQQPPQLLQVEFLRLSTHEDPQLLDDTLAKVPWSLLRLRSLVLKGGQSRGALGACLHGTLTTLPAGLSDLACLAHLDLSFNRLETLPTCVPELHGLDALLLSHNHLSELPEALGALPALTFLTVTHNRLERLPLTLGSLSTLQRLDLSENLLDTIPSEIGNLRSLSELNLASNRLQSLPASLAGLRSLRLLVLHSNLLTSVPTGLVHLPLITRLDLRDNRLRDLPAELLDAPFVRLQGNPLGEASPAPPSPPDISQVPEMPRLLLTSDLDSFLVTPHGCSVTLACGVRLQFPAGATTTPVTIHYRLWLPEPGLVSLGPHDFLLSSVLELQPHGVAFQQDVSLWLLFVPPRVRRCREVVVRTRSNNTWNDLETQLEEEAPKRLWARCQVPHFSWFLVVLRPVSNTCLLPPEGALLCSSGHPGVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLSQSGPPSFLQPVTVQLPLPPGVTGFSLDRSHLHLLYRTPLTTTWDDITTQVALEFTHLYARFQVTHFSWYWLWYTTKTCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLSRLLVRYRGPEPSETVEMFEGEKFFAAFERGIDVDADRPDCVDGRICFVFYSHLKNVKEVYITTALDREAQDVRGQVSFYRGSLPVEVPAEAEAARQRKGTDALWMATLPIKLPRLRGAQGSGQGTDFSLMPLNLGDAETGFLTQSNLLSVASRLGPDWPAVALHLGMPYHKLQRIRHEFRDDLDGQVRHMLFSWAERQTGQPGAVGHLVQALEQSDRRDVAEEVRAILELGRHKYQDSIRRTGLAPEDSTLPGTSASQTPESAQA
Protein: Coenzyme Q-binding protein COQ10 homolog B, mitochondrial (Q3THF9)
Organism: Mus musculus (Mouse)
Function: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Interaction partners:
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Ubiquinone biosynthesis protein COQ9
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
Sequence:
MAARTSQRALARVASGCHPKSTTVTEATARGSARDVRHLAACGVLINRTLPPCAAVLPKEICARTFFRISAPLVNKRKEYSERRILGYSMQEMYDVVSGMEDYQHFVPWCKKSDIISRRSGYCKTRLEVGFPPVLERYTSIVTLVKPHLVKASCTDGKLFNHLETIWRFSPGLPGYPRTCTLDFSISFEFRSLLHSQLATLFFDEVVKQMVAAFERRACKLYGPETNIPRELMLHEIHHT
Protein: Polycomb protein esc (Protein extra sex combs) (Q26458)
Organism: Drosophila virilis (Fruit fly)
Function: Polycomb group (PcG) protein. In contrast to other PcG protein, it is specifically required during the first 6 hours of embryogenesis to establish PcG silencing. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via a methylation of histones, rendering chromatin heritably changed in its expressibility. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. The Esc/E(z) complex is necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MSSEKVKNDNEPDDTDDSCGDESASFTTNSTTSRSKSPASSTRSKRRGRRSHKSKPKSGAAYKYDTHVKENHGANIFGVSFNTLLGKDEPQVFATAGSNRCTVYECPRKGGLTLLHCYADPDPDEVFYTCAWSYDLKTSAPLLAAAGYRGVIRVIDIEQNEAVDNYIGHGQAINELKFHPHKLQLLLSGSKDHAIRLWNIQTHVCIAIFGGVEGHRDEVLSIDFNMRGDRIVSSGMDHSLKLWCLNTQEFQHKIELSQTFSQEKSTLPFPTITKHFPDFSTRDIHRNYVDCVQWFGNFVLSKSCENAIVCWKPGQLHQSFEQLKPSDSSCTIIAEFEYDECEIWFVRFGFNPWQKVIALGNQQGKVYVWEMDPSDPEGAHMTTLHNLRSVATVRQIAFSRDASVLVYVCDDATVWRWNRRHAAAI
Protein: GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras) (Q04970)
Organism: Rattus norvegicus (Rat)
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P01111}; Lipid-anchor {ECO:0000250|UniProtKB:P01111}; Cytoplasmic side {ECO:0000250|UniProtKB:P01111}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P01111}; Lipid-anchor {ECO:0000250|UniProtKB:P01111}. Note=Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250|UniProtKB:P01111}.
Interaction partners:
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
- Neurofibromin
- RAF proto-oncogene serine/threonine-protein kinase
- SOS Ras/Rac guanine nucleotide exchange factor 1
- Serine/threonine-protein kinase A-Raf
- SOS Ras/Rho guanine nucleotide exchange factor 2
- Ral guanine nucleotide dissociation stimulator
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSEDGTQGCMGLPCVVM
Protein: Vacuolar calcium ion transporter (High copy number undoes manganese protein 1) (Manganese resistance 1 protein) (Vacuolar Ca(2+)/H(+) exchanger) (Q99385)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:8668190}; Multi-pass membrane protein {ECO:0000269|PubMed:8668190}.
Interaction partners:
- Calcium-transporting ATPase 2
- Calcium-transporting ATPase 1
- Calcium-channel protein CCH1
- Stretch-activated cation channel MID1
- Transcriptional regulator CRZ1
- Calcipressin-like protein
- Calcium channel YVC1
- Calcineurin subunit B
- Divalent cation/proton antiporter GDT1
Sequence:
MDATTPLLTVANSHPARNPKHTAWRAAVYDLQYILKASPLNFLLVFVPLGLIWGHFQLSHTLTFLFNFLAIIPLAAILANATEELADKAGNTIGGLLNATFGNAVELIVSIIALKKGQVRIVQASMLGSLLSNLLLVLGLCFIFGGYNRVQQTFNQTAAQTMSSLLAIACASLLIPAAFRATLPHGKEDHFIDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEETDEVMSTISRNPHHSLSVKSSLVILLGTTVIISFCADFLVGTIDNVVESTGLSKTFIGLIVIPIVGNAAEHVTSVLVAMKDKMDLALGVAIGSSLQVALFVTPFMVLVGWMIDVPMTLNFSTFETATLFIAVFLSNYLILDGESNWLEGVMSLAMYILIAMAFFYYPDEKTLDSIGNSL
Protein: LD21345p (SD07604p) (Sister-of-Sex-lethal, isoform B) (Sister-of-Sex-lethal, isoform E) (Q8IH14)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSNADKMQDQEHDDEQSSDIEGSGDNVGRDDGTDDDDDSNGNMQQENGDGGNGGDGQEHSGDEEQHHSQDNEGNDNSAGQQQQMQQVDRTSATNLIINYLPQDMTDRELYNLFSGCGPINTCKIMRDFKTGYSFGYGFVDYKTESDSEDAIQKLNGFYVRNKRLKVSYARPGGQSIKDTNLYVINLSRNINDDMLDRIFSPYGLIVQRNILRDKLTGRPRGVAFVRYNKREEAQEAIKALNNTVPEGGSQPIWVRLAEEHGKAKAAQFMAQIGGGNGGGGGGPPHMGPGGPMHPPHHHNNHHHNNHHNPHMPPHHHQPQHPHQHPQHHPQLHHMQHHHPNNHNNNHPNNHHHNNNNNNHHNMGGPHPHHMQQMHPMGMNMGMGVNMGMGMGMGMPIHGGGGGGGGGGGGGGGGNFHHMAHRGRSNRTTRSQKPHPYNHAQKFI
Protein: LD21931p (Q9VD52)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Pre-mRNA-splicing factor Syf2
- Splicing factor YJU2
- Pre-mRNA-splicing factor Slu7
- Cwc25
- Cell division cycle 5, isoform A
- Pre-mRNA-splicing factor CWC22 homolog
- MIP04834p
- 116 kDa U5 small nuclear ribonucleoprotein component
- RNA helicase
- U5 small nuclear ribonucleoprotein 200 kDa helicase
Sequence:
MLGLQSYASSSDEESDHADAATATTNSEPSAPIPDHLLPVDKTHSLSKSIAVCAAPTVVPLGASAVPRTLDPTLKEVTYNPRYEEMYAPVKGPEHPDLTMQQRAPRNTLAGYVEKAHINAFEFENQRRTFHTYGYALDPSVDDQADGQSFVGDLQSAYDDNGKTVFEPPKAKKLRKQEKNDNPEDIEGFLGPWGKFENEVSVAKPNEQERAELDELLSKRHKRGRIPEDKPLEEKSTLHIKDAYDYQGRSYLHAPHDLGVNLRSNAPPTKCFLPKAHIHTWSGHNKGISSIRWFPKTAHLLLSGSMDCRVKLWEVYGERRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNSKQHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTSDDKSMRIWEWDIPVDMKYIADPTMHSMPAVTLAPNGKWMACQSLDNKIVIFSALNRFKMNRKKTFTGHMVSGYACQLDFSPDMSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPHEASKVVTAGWDGQIKYWD