wanglab/gogpt-training-data huggingface dataset:
Protein: Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog (Q9XW12)
Organism: Caenorhabditis elegans
Function: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
Interaction partners:
- MIP18 family protein F45G2.10
- MMS19 nucleotide excision repair protein
- Probable cytosolic Fe-S cluster assembly factor oxy-4
- Cytosolic Fe-S cluster assembly factor NUBP1 homolog
- General transcription and DNA repair factor IIH helicase subunit XPD
- Probable glycerol kinase
Sequence:
MLRQIGEFYHQGEKDDTSRVWMTCWHHGGRILASCGDDKAVRVWSLVGEPDSKMRLECRTTLDDSHTRAVRSVAFSNDGKCLVSASFDASVVVYQQEDGEFAEVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWQQDEDEDFSVSSILQPHTQDVKQVAWHPTEDLLVSCSYDSSIRFYRFDGEDWVTQQKIDGCHVGTVWSIAFDTEGHRLVTVGEDHCIQLFVRENIGSKSADQDTWKSVARYDVENTRWPLYSVAWNSTNDVIATGGGDCKIRLFKISSTPESPVIEHLGVVGRHELDVNHVAWNPNPKFSNLLTSASDDGTIRLWELEI
Protein: WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22) (Q96P53)
Organism: Homo sapiens (Human)
Function: Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis.
Subcellular location: Endosome {ECO:0000269|PubMed:16873553}. Early endosome {ECO:0000269|PubMed:16792529}. Cytoplasm {ECO:0000250|UniProtKB:Q8BUB4}. Note=Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity). {ECO:0000250|UniProtKB:Q8BUB4, ECO:0000269|PubMed:16792529, ECO:0000269|PubMed:17313651}.
Interaction partners:
Sequence:
MAAEIQPKPLTRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTATFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPVVS
Protein: Cacna1h protein (Q6PE92)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MTEGTLAADEVRVPLGASPSAPAAPVRASPASPGVPGREEQRGSGSSVLAPESPGTECGADLGADEEQPVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHISMLVIMLNCVTLGMFRPCEDVECRSERCSILEAFDDFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVMAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPSRRELRVQCTLGWEAYGQPQAEDGGAGRNACINWNQYYNVCRSGEFNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRENQLMREQRARYLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSSTLHGQGPRRRPRRAGRRTASVHHLVHHHHHHQKKKKKKKKKKKKKKK
Protein: Muscarinic acetylcholine receptor M1 (P12657)
Organism: Mus musculus (Mouse)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Metabotropic glutamate receptor 5
- Muscarinic acetylcholine receptor M5
- Lysophosphatidic acid receptor 6
- Guanine nucleotide-binding protein subunit alpha-11
- Muscarinic acetylcholine receptor M3
- Kininogen-1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Lysophosphatidic acid receptor 1
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
Protein: PAR-domain protein 1, isoform L (M9PEX4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRMDYQMPPPALALQQQQQHGMQHQQQQLQLLQNVQQQQQQQQQQQQQHQQQQLLGNMSQTAALPPLSSLPLQVVHNLPHLLAGNSGGNTGNNPNTSNSNLNVACNNNLLRGNMQHQQQQQQLLNNLSNGNNVASGTLPPPTQLLQHHLQHLAHVNVNAAAAVVAVAANNLQQQQQQQQHASSNNVTGGSPGSNSNNNNNNNNILNHNNLNIIINNHASLNNNNNNSNNNNNNNNNPATPNANLAASNNATPTVNTASAVAQQQQAHENSLVNSLVGVINNSNNNNNNTNNNNNNNTNSNSNNNNNNSVGGDDNNRWTQFQVQQLWKQHANYLNGRKSPFLGFICKSNGKSTSNSKEIICPDDKYKEEGDIWNVEAQTAFLGPNLWDKTLPYDADLKYADLDEFLSENNIPDGLPGTHLGHSSGLGHRSDSLGHAAGLSLGLGHITTKRERSPSPSDCISPDTLNPPSPAESTFSFASSGRDFDPRTRAFSDEELKPQPMIKKSRKQFVPDELKDDKYWARRRKNNIAAKRSRDARRQKENQIAMRARYLEKENATLHQEVEQLKQENMDLRARLSKFQDV
Protein: ANK_REP_REGION domain-containing protein (Q93203)
Organism: Caenorhabditis elegans
Interaction partners:
- BTB domain-containing protein
- CEntrosomal Protein
- DUF2045 domain containing protein
- Protein lin-2
- Protein clarinet
Sequence:
MSLKDFVISKTEVIDACKKGEYDKVALFLSSKKGKKIRSGLKFFTTRSDSHWLADYKDEKSDFTLLHHAVLENQNQISKLLMDYEPLLLLCKSTKNILPIHLAAWNGNLEIVKMLLLQTMEKPADILNAVNIFNETPLHLAVQRCHLEVVFYLIKKNADPFIRNENKENVIDVASRIGSAEAIRMLCQKWPKFPVQSAYESLRVGTPDIKRPFPAIYPFHLAAKYNHVECMQALREHGFSINYTTEDGTALHVASACGQAEAVRFLLEIGVNTDIKNQHGQTVLQMIIDLQENRRNEIAHFVKNPEGWKECRTIIEGMDRRDSGRETEGSQSDNEREAIWQPLPSQASVQVYPDQRRNNHSIYQPPSISARLRDLSPDDSTEALNSVRSEGPYTTHSINRTWNSSMLDRAPRTGRFPLTSPSYHSKHYSCQRSSDTLPTRLKNVRTRPTEKQIASVLPGDNCAYNSPSKFNEWQKSQLTISNRPPAPYDNVPNNSAIFVRPNSPIARSASLRRQSGYATLPKLATYSPRIPDHGRPDLNDAFIQDPDKTMDRSLNRNQFSISRTTCDREESLGLTQSPRLDTRASSITSSLTYACSTLDKDKFFRERERDNGRAPLAMPEEITGSVTGSVIYSQGNANQHLNGNYEKDNNVTAIFLEDVMRPSSNSAESPPSPNTSKAFIFDALCGKSRLVDSTNVDFFSGFSSSSNLSHRSTESTSKVQMNSSFTEPEEPVRIRRQNGTTNLMLNSLSPTDNLSSPSSDQKSDTTSEEPSWDRVESVFDSFGAAPCRESVFVREYEPRVAVYLRDRGSKALSVTLVEDEFRDHKSLLVKKQPKTIIEWLESDVMLAPVAADSVGALLQTHGYDRMDQLKGIINRSILTEIGVDDVTKFKIMSEIEKLKDDVASAGRFFYVSEWLNFIGLQDYISNFVGAGYKHMAKLTEIDWDTARLMQLGVTRPGHIARMLHSFKKAEDEKRKEYNNRLQIKPLMSPPPLPPRSKQNNCAECPQGDFDKIKNKLLQGNVVYRAHHLGVLEIGETECSDEAHAAMTRIKESIIDWETIPRVTLDLTCNGITIFDETFKTLLDGYGVYTIRVVCQDRKDLNFFCFVARDTENRFFCHTFCVLTSGIAAEIITTIGMMFELRSRMDKSLPIEGTMVRCRHNSQQTTENQRN
Protein: Zinc finger protein 710 (Q8N1W2)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MEGFMDSGTQTDAVVVLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELSGAAMGEPEPPGPDVYQLACNGRALEEPAEEEVLEVEAACEKHTRRKTRPPVRLVPKVKFEKVEEEEQEVYEVSVPGDDKDAGPAEAPAEAASGGCDALVQSSAVKMIDLSAFSRKPRTLRHLPRTPRPELNVAPYDPHFPAPARDGFPEPSMALPGPEALPTECGFEPPHLAPLSDPEAPSMESPEPVKPEQGFVWQEASEFEADTAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDIGLDSQDPMMELTGTDPSELDGQQEMEDFEENAYSYASVDSSAEASVLTEQAMKEMAYYNVL
Protein: 75aa long hypothetical regulatory protein AsnC (O73983)
Organism: Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Interaction partners:
- HTH-type transcriptional regulator FL11
- Uncharacterized HTH-type transcriptional regulator PH0061
Sequence:
MVTAFILMVTAAGKEREVMEKLLAMPEVKEAYVVYGEYDLIVKVETDTLKDLDQFITEKIRKMPEIQMTSTMIAI
Protein: Calretinin (A0A140VK08)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSKSDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSAEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKDRSGYIDEHELDALLKDLYEKNKKEMNIQQLTNYRKSVMSLAEAGKLYRKDLEIVLCSEPPM
Protein: Large ribosomal subunit protein mL49 (39S ribosomal protein L49, mitochondrial) (L49mt) (MRP-L49) (Neighbor of FAU) (NOF) (Protein NOF1) (Q13405)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Interaction partners:
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein mL41
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein mL44
Sequence:
MAATMFRATLRGWRTGVQRGCGLRLLSQTQGPPDYPRFVESVDEYQFVERLLPATRIPDPPKHEHYPTPSGWQPPRDPPPNLPYFVRRSRMHNIPVYKDITHGNRQMTVIRKVEGDIWALQKDVEDFLSPLLGKTPVTQVNEVTGTLRIKGYFDQELKAWLLEKGF
Protein: Assembly-complementing factor 4 (P47129)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in actin cytoskeleton organization and biogenesis.
Interaction partners:
- Reduced viability upon starvation protein 167
Sequence:
MSEDQRVISQPIELHKLSIVDKHSQGQQQQPHQKQHEVQPESKSPRVTTPLKPKRLAIPISSPQRSTTNQSPVSDHASPISTDQDLIYKLAAKHREINELSFKLEVAQKELKQLELQFKDTLPRNGQQKLGNQNPSEYLSTFTKRIQQTFVDVNNSPNMLKGKKSINDFFSKPNNNVNSNINNTLPNRKPNPPPNRSQRMQNIAPSRSSESTPTSGPPLLPPRNTMKNANTTATAGENTPFLQRILNKFNQMNMEEDEFDDLLEKRKSKKDHYYIKENLGYEYDEVRSEDEDDEEFEPMGDIPVHLFKR
Protein: SH3 domain-containing protein (E6N0W1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MRSTRDEKVARIKELQETNQKTAIESQELGHQLLQKQSAHKETTQRKSELEALRRKRDAIRKAIEDAALELSTEKEKSYNQTEILKTNKEKYKTDVYSKLVAKREEYRNSFELLVHAQTHARSKIGEFEAKSAPASAAPAPAPAPAPTTTNGFPANFNDAFGEFDKTDASQRFDADFGATSTADPFAQIAQAPAHSKGAVDQSAFNIHDTYKCRALFAFEARSEDELSFEPGDVIIVFQSHAAEPGWRAGQLREKVGWFPEAFVEAIAAVPTPGGDPPIQNMPPNMTPSSSVDQIGVKAARKAEIAAAMGLTEGGAPPASSAPAAAAVISQCIAQFQWRARNEEDLSFAKGDTIEVLEKQEMKWKGRNPAGEIGWFPKSYVKEVGATTSTTTPIVSPSKASAGAPGAAAGAQYDVVPSDVTLQASETAPQQQLYTVIYDFEAVETTDLALHVGDTILVLEKNDEWWKGRCNGREGIFPANYVEISVQQAGDPTPPTQAPTPAAPPTVLCEAKVVVDFVASAPNQLGIKVGEIVKIREKSAAGWWEGELIRNGKPIAGWFPGEYVKVLEEAASPATRATAVYDYEASQPDELGFKTGDVIIVTDKSEAEWWSGHREQDPSKSGLFPSNYVQQQ
Protein: Peroxiredoxin DOT5 (Prx) (EC 1.11.1.24) (Disrupter of telomere silencing protein 5) (Nuclear thiol peroxidase) (nTPx) (Thioredoxin peroxidase) (Thioredoxin-dependent peroxiredoxin DOT5) (P40553)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen peroxide. Acts as an antioxidant necessary for stationary phase survival.
Subcellular location: Nucleus {ECO:0000269|PubMed:10681558, ECO:0000269|PubMed:12925864, ECO:0000269|PubMed:14562095}. Chromosome, telomere {ECO:0000305}.
Interaction partners:
- Tryptophan synthase
- Peroxiredoxin AHP1
- Peroxiredoxin PRX1, mitochondrial
- Peroxiredoxin TSA1
- Peroxiredoxin TSA2
- Multifunctional tryptophan biosynthesis protein
- Glutathione peroxidase-like peroxiredoxin HYR1
- Glutathione peroxidase-like peroxiredoxin 1
- Peptide methionine sulfoxide reductase
- Catalase T
Sequence:
MGEALRRSTRIAISKRMLEEEESKLAPISTPEVPKKKIKTGPKHNANQAVVQEANRSSDVNELEIGDPIPDLSLLNEDNDSISLKKITENNRVVVFFVYPRASTPGCTRQACGFRDNYQELKKYAAVFGLSADSVTSQKKFQSKQNLPYHLLSDPKREFIGLLGAKKTPLSGSIRSHFIFVDGKLKFKRVKISPEVSVNDAKKEVLEVAEKFKEE
Protein: Transcriptional repressor XBP1 (XhoI site-binding protein 1) (P40489)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional repressor which binds to the consensus sequence 5'-GCCTCGA[G/A]G[C/A]-3'. Represses CLN1 transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcriptional activator HAC1
- Cyclin-dependent kinase 1
- Nutrient and stress factor 1
- Transcriptional regulatory protein UME1
- G2/mitotic-specific cyclin-2
- Protein DDR2
- Zinc finger protein MSN4
Sequence:
MKYPAFSINSDTVHLTDNPLDDYQRLYLVSVLDRDSPPASFSAGLNIRKVNYKSSIAAQFTHPNFIISARDAGNGEEAAAQNVLNCFEYQFPNLQTIQSLVHEQTLLSQLASSATPHSALHLHDKNILMGKIILPSRSNKTPVSASPTKQEKKALSTASRENATSSLTKNQQFKLTKMDHNLINDKLINPNNCVIWSHDSGYVFMTGIWRLYQDVMKGLINLPRGDSVSTSQQQFFCKAEFEKILSFCFYNHSSFTSEESSSVLLSSSTSSPPKRRTSTGSTFLDANASSSSTSSTQANNYIDFHWNNIKPELRDLICQSYKDFLINELGPDQIDLPNLNPANFTKRIRGGYIKIQGTWLPMEISRLLCLRFCFPIRYFLVPIFGPDFPKDCESWYLAHQNVTFASSTTGAGAATAATAAANTSTNFTSTAVARPRQKPRPRPRQRSTSMSHSKAQKLVIEDALPSFDSFVENLGLSSNDKNFIKKNSKRQKSSTYTSQTSSPIGPRDPTVQILSNLASFYNTHGHRYSYPGNIYIPQQRYSLPPPNQLSSPQRQLNYTYDHIHPVPSQYQSPRHYNVPSSPIAPAPPTFPQPYGDDHYHFLKYASEVYKQQNQRPAHNTNTNMDTSFSPRANNSLNNFKFKTNSKQ
Protein: Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) (Q8NFT2)
Organism: Homo sapiens (Human)
Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:Q8BWB6}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:12429817}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- STEAP1 protein
- Early endosome antigen 1
- Kallikrein-2
- Prostatic acid phosphatase
- Protein-glutamine gamma-glutamyltransferase 4
Sequence:
MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM
Protein: 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase (OTEMO) (EC 1.14.13.160) ((2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase) (MO2) (H3JQW0)
Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
Function: Involved in the degradation of (+)-camphor. Catalyzes the lactonization of 2-oxo-delta(3)-4,5, 5-trimethylcyclopentenylacetyl-CoA (OT-CoA), a key intermediate in the metabolism of camphor. 2-Oxocyclopentyl ethyl acetate is also a good substrate, as is 2-oxocyclohexyl ethyl acetate and methyl-substituted cyclohexanones, but free acid is a poor substrate.
Interaction partners:
Sequence:
MSNRAKSPALDAVVIGAGVTGIYQAFLINQAGMKVLGIEAGEDVGGTWYWNRYPGCRLDTESYAYGYFALKGIIPEWEWSENFASQPEMLRYVNRAADAMDVRKHYRFNTRVTAARYVENDRLWEVTLDNEEVVTCRFLISATGPLSASRMPDIKGIDSFKGESFHSSRWPTDAEGAPKGVDFTGKRVGVIGTGATGVQIIPIAAETAKELYVFQRTPNWCTPLGNSPMSKEKMDSLRNRYPTILEYVKSTDTAFPYHRDPRKGTDVSESERDAFFEELYRQPGYGIWLSGFRDLLLNKESNKFLADFVAKKIRQRVKDPVVAEKLIPKDHPFGAKRVPMETNYYETYNRDNVHLVDIREAPIQEVTPEGIKTADAAYDLDVIIYATGFDAVTGSLDRIDIRGKDNVRLIDAWAEGPSTYLGLQARGFPNFFTLVGPHNGSTFCNVGVCGGLQAEWVLRMISYMKDNGFTYSEPTQAAENRWTEEVYADFSRTLLAEANAWWVKTTTKPDGSVVRRTLVHVSGGPEYRKRCEQVAYNNYNGFELA
Protein: Adenosine deaminase (EC 3.5.4.4) (A0A0K1SC59)
Organism: Plasmodium gallinaceum
Function: Catalyzes the hydrolytic deamination of adenosine to produce inosine. Unlike other Plasmodium adenosine deaminases, does not catalyze the deamination of 5'-methylthioadenosine (MTA). Plays an essential role in the purine salvage pathway which allows the parasite to use host cell purines for the synthesis of nucleic acids (Probable).
Interaction partners:
Sequence:
MTILHEEINFLKKDELNINLKCLDKKERYKIWRRIPKCELHCHLDLCFSLEFFLKCVRKYNLQPDLTDDEVVDYYLFKDKGKSLNEFIERSRRVTDIFINYDIIKDIAKNAVFNKYKEGVILIEFRYSPSYIAYKYNLCIDLIHKTIVEGINEAVEKLNHKIHVGLICIGETGISEESLRKAAEFCVKNKKDFVGFDHAGHERDLKPYKEIYDYVRENGIPLTIHAGEDLTLPNLNTIYSAIEVLKAKRIGHGIRVIESEDLINLIKKNDILLEICPISNLLLNNVKSMDTHPIKKLYDSGIKVSVNTDDPGMFLTEINDEYEELYLNLNFNLEDFMKMNLWALEKSFVKSEIKDKLKKLYF
Protein: GH05102p (Q9VR44)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- LP13633p
- GH25012p
Sequence:
MSNTEKGGLQRVRNFLSCRQVLNLLTMLGFMLNYALRVNLTIAIVDMVRPNVTSAVNATLVGNSTAANSTASPDGVDVYEERFPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHINYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSKFMSNMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRISAEERREIEEAIGTTTSKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKGTLSTTATRKLFTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGLDIAPNFGGTIFGLANTLSSFGGFLSTSMVGALTYKDQSFHSWQIVFWILAATYISAAVVFAILGSGELQPWNNPPERVRISDVTQEEGVPLKNEK
Protein: Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1) (Epididymis luminal protein 141) (HEL-141) (P21291)
Organism: Homo sapiens (Human)
Function: Could play a role in neuronal development.
Subcellular location: Nucleus {ECO:0000269|PubMed:26924529}.
Interaction partners:
- Metal regulatory transcription factor 1
- Mediator of RNA polymerase II transcription subunit 14
- Rhombotin-1
Sequence:
MPNWGGGKKCGVCQKTVYFAEEVQCEGNSFHKSCFLCMVCKKNLDSTTVAVHGEEIYCKSCYGKKYGPKGYGYGQGAGTLSTDKGESLGIKHEEAPGHRPTTNPNASKFAQKIGGSERCPRCSQAVYAAEKVIGAGKSWHKACFRCAKCGKGLESTTLADKDGEIYCKGCYAKNFGPKGFGFGQGAGALVHSE
Protein: Myosin-binding protein H-like (A2RUH7)
Organism: Homo sapiens (Human)
Function: Myosin-binding protein which plays a role in cardiac function. Seems to regulate conduction in the atria and ventricular conduction systems.
Subcellular location: Cytoplasm, myofibril, sarcomere {ECO:0000305|PubMed:28778945}.
Interaction partners:
- Proline/serine-rich coiled-coil protein 1
- Cadherin EGF LAG seven-pass G-type receptor 2
- Myosin regulatory light chain 2, atrial isoform
Sequence:
MEAATAPEVAAGSKLKVKEASPADAEPPQASPGQGAGSPTPQLLPPIEEHPKIWLPRALRQTYIRKVGDTVNLLIPFQGKPKPQAIWTHDGCALDTRRVSVRNGEQDSILFIREAQRADSGRYQLRVQLGGLEATATIDILVIERPGPPQSIKLVDVWGFSATLEWTPPQDTGNTALLGYTVQKADTKSGLWFTVLEHYHRTSCIVSDLIIGNSYAFRVFAENQCGLSETAPITTDLAHIQKAATVYKTKGFAQRDFSEAPKFTQPLADCTTVTGYNTQLFCCVRASPRPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCKAVNPLGEASVDCRVDVKVPN
Protein: Mitogen-activated protein kinase kinase kinase mlk-1 (EC 2.7.11.25) (Mixed lineage kinase homolog 1) (A0A0K3AV08)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase which, by phosphorylating and activating mek-1, plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Involved in the response to environmental stress such as heavy metals. By activating the JNK pathway downstream of tyrosine receptor svh-2, plays a role in axon regeneration after injury.
Interaction partners:
- Mitogen-activated protein kinase pmk-3
- Dual specificity mitogen-activated protein kinase kinase jkk-1
- Serine protease svh-1
- Tyrosine-protein phosphatase vhp-1
- E3 ubiquitin-protein ligase parkin
- Dual specificity mitogen-activated protein kinase kinase sek-1
- MAP kinase-activated protein kinase mak-2
- Tyrosine-protein kinase receptor svh-2
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase
- E3 ubiquitin-protein ligase rpm-1
Sequence:
MEQASVPSYVNIPPIAKTRSTSHLAPTPEHHRSVSYEDTTTASTSTDSVPEVRIRSESSQVSRESPPIRASKAFVASYEYEAQKDDELNLPLGAIITLVTVETNEDGWYRGELNGKVGLFPSNYAREVTYKDNLVEFKQDEIMLPVAVRTLSDCQIGHGATATVFKMDIKIKKELQNGRMGEAVGDQMKAALKRFNRHASNFRADVVSTDEQLEQLKREANLVNGLSHNNIVRLLGICLEDPYFGLLLELCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEGMEYLTKQGYVHRDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTADANRFSTAGTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNLSIGDSCPDRWKKLMQDCWNLEPNFRPKFSTLAISFKQYAKEFKDTHLQRAPSKMAVKELYSECFADKTKEEFEKRFHDLYAGSGDINRKNRHSIAPETKARRLKHHKPKKADITGPTEVKHILSVQKDDKNFRVKTYDQSSTGGTLPRLNERQSTLSLSSPDLFHISNLISGSNTVGHSAHRISRKNAIRHKKNQHRMFESPVVSPTMDDSNTFSTIDNADEVDPNHSKESKKGGTLSRAWAKLPWNKRDSKEDHDERAVAGSISSRSSSTTSSNRLITGQTTRGASAAGLLEIGARSRAQSTADGWEDPNTTKKHKVSPSDKRPVKTTNQTERYVKDLEKDTPLRPAQLPPTHRKSALDQTIPASPNSPDSINNFHPMPLSSRRTTANSSSDGAPCYDALVSHSYGAGHGHKNHFGLSDTIPLFPEEPTHYDMGPGRPFGTNGRAIVNQGGDYYGNISGQNYEGFGHGRSINQSTQYYPVGGGCDDYIPIVQKTVIKPTVGEVGNSPYSENIRCATRNVQNPQYIQCKKNQNPRRIPALPMKIQSESNLVTSGMVFTPRDEQLNGIGNSLSSLSLNEPPDIPAPLPPVVTYPIPASLISPSNRVSMSPPTRMAPVLPLGAMSSPRIMDKEILKNSSVEGTEIY
Protein: Ribosomal small subunit pseudouridine synthase A (EC 5.4.99.19) (16S pseudouridylate 516 synthase) (16S rRNA pseudouridine(516) synthase) (rRNA pseudouridylate synthase A) (rRNA-uridine isomerase A) (P0AA43)
Organism: Escherichia coli (strain K12)
Function: Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA.
Interaction partners:
- Dual-specificity RNA pseudouridine synthase RluA
- tRNA pseudouridine synthase B
- tRNA pseudouridine synthase D
- tRNA pseudouridine synthase A
- Ribosomal large subunit pseudouridine synthase D synthase)
- GTPase Der
- Bicyclomycin resistance protein
- tRNA pseudouridine synthase C
Sequence:
MRLDKFIAQQLGVSRAIAGREIRGNRVTVDGEIVRNAAFKLLPEHDVAYDGNPLAQQHGPRYFMLNKPQGYVCSTDDPDHPTVLYFLDEPVAWKLHAAGRLDIDTTGLVLMTDDGQWSHRITSPRHHCEKTYLVTLESPVADDTAEQFAKGVQLHNEKDLTKPAVLEVITPTQVRLTISEGRYHQVKRMFAAVGNHVVELHRERIGGITLDADLAPGEYRPLTEEEIASVV
Protein: Cell wall integrity/stress response component (Q9FKX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g03450
- Receptor-like serine/threonine-protein kinase SD1-6
- UMP kinase
- E3 ubiquitin-protein ligase makorin
- Dirigent protein 21
- Protein trichome birefringence-like 19
- Small ribosomal subunit protein mS86
Sequence:
MASAHSIAAVSVLDAASKQATLPSSSSSSSALYPLSSLRSKPRQQLLSLRSVALKGRVKAQAKEAEASPSPVGVGDAFSNVKHLLLPVIDRNPYLSEGTRQAAATTTSLAKKYGADITVVVIDEEKRESSSEHETQVSNIRWHLSEGGFEEFKLLERLGEGKKATAIIGEVADELKMELVVMSMEAIHSKYIDANLLAEFIPCPVLLLPL