Protein: Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) (Myosin heavy chain myr 2) (Q63355)
Organism: Rattus norvegicus (Rat)
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O00159}. Nucleus {ECO:0000250|UniProtKB:O00159}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9WTI7}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q92002}. Cytoplasmic vesicle {ECO:0000269|PubMed:22918957}. Cell projection, ruffle membrane {ECO:0000269|PubMed:22918957}. Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane (By similarity). Colocalizes in adipocytes with GLUT4 at actin-based membranes (By similarity). Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane (PubMed:22918957). Localizes transiently at cell membrane to region known to be enriched in PIP2 (By similarity). Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity). Colocalizes with RNA polymerase II (By similarity). Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription (By similarity). {ECO:0000250|UniProtKB:O00159, ECO:0000250|UniProtKB:Q9WTI7, ECO:0000269|PubMed:22918957}.
Interaction partners:
- Actin, cytoplasmic 2
- Myosin-IIIa
- Capping protein regulator and myosin 1 linker 1
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
- Tyrosine-protein kinase BAZ1B
- Splicing factor 3B subunit 1
- Protein DEK
- Nucleolar RNA helicase 2
- Myb-binding protein 1A
- Unconventional myosin-Ia
Sequence:
MRYRASALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYTRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHVFYQLLEGGEEEALRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALSVIDFTEDEVEDLLSIVASVLHLGNIHFAADEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTIKHHPHFLTHKLADQKTRKSLDRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSTNPIMAQCFDKSELSDKKRPETVATQFKMSLLQLVEILRSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPVWTGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFILRHAPRCPENAFFLDHVRTSFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTEEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPSAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQREDSKQKGDVVLQSDHVIETLTKTALSADRVNNININQGSITFAGGPGRDGIIDFTSGSELLITKAKNGHLAVVAPRLNSR