wanglab/gogpt-training-data huggingface dataset:
Protein: Iroquois homeobox protein Ziro1 (Q90XQ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MSFPQLGYPQYLSASQAVYGGDRPGVLTPSSRAGSAEIGGSASAAAAAMSSVLGMYPYAHNYSAFLPYTSADLALFSQMGSQYDLKDSPGVHPASFAAHTSPAFYPYGQFQYGDPARPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDDENIFGSDNEGDAEKNEDEEEIDLESIDIDKIDDNDGDQSNEEDEDKRAELESLQEKRHASKEPSDGNNNTTRVLSPGRQGGFQVPVSNKPKIWSLAETATSPDSAQKPTSPSVPVSHPAFLPSHGLYTCQIGKFHNWTNGAFLGQNSLLNVRSFLGVNQHNHPAQQQQQQTGPASLQVLSAGNTDKMPEDLSPKHIDRENVLRNESPTQPLKSSFRPLHDSPRNQQESTQRVLTALSSA
Protein: Snurportin-1 (RNA U transporter 1) (O95149)
Organism: Homo sapiens (Human)
Function: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
Subcellular location: Nucleus {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:38413582}. Cytoplasm {ECO:0000269|PubMed:12095920, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026, ECO:0000305|PubMed:10209022}. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920). It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway (PubMed:10209022). {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:12095920}.
Interaction partners:
- Exportin-1
- Importin subunit beta-1
- GTP-binding nuclear protein Ran
- Nuclear pore complex protein Nup214
- Small nuclear ribonucleoprotein-associated proteins B and B'
- Small nuclear ribonucleoprotein E
- Probable ATP-dependent RNA helicase DDX20
- Target of EGR1 protein 1
- RNA-binding protein MEX3B
- Small nuclear ribonucleoprotein Sm D1
Sequence:
MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN
Protein: ADP/ATP translocase (ADP,ATP carrier protein) (Q6I9V5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368008}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368008}.
Interaction partners:
Sequence:
MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI
Protein: Phosphomannomutase (PMM) (EC 5.4.2.8) (P31353)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Subcellular location: Cytoplasm.
Interaction partners:
- Mannose-1-phosphate guanyltransferase
- Mannose-6-phosphate isomerase
- Psa2p
- Phosphotransferase
- Phosphotransferase
- Hexokinase-2
- N-acetylglucosamine kinase 1
- Protein FMP32
- Glucose-6-phosphate isomerase
Sequence:
MSFANKQDPKTLVLFDVDGTLTPARLTISEEMKKTLEKLREKVVIGFVGGSDLSKQVEQLGPNVLNDFDYCFSENGLTAYKLGKELASQSFINWIGNEKYNKLVKFILRYLSDIDLPIRRGTFIEFRNGMINVSPIGRNASTQERNDYEKFDKQHHIRETMVEALKKEFPDFGLTYSIGGQISFDVFPTGWDKTYCLQHVEDEHFENIHFFGDKSYKGGNDYEIYNDPRTIGHAVNSPDDTIRILNETFKLQ
Protein: POU domain protein (O73861)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MAAAAQYLPRSAGLLHPDGDRLHQGTTYREVQKMMHHEYLQGLAPAAAGHAVGLAHHQWLPSAGTDWGSGGGGGGGAHLPPAAEHGKGGPGGPREELPPAAAFHPRPHLVRTGRWAQGGAAPHLPPMSPPSGQPLLYGQPYGGLNGMLGPPGPALHHGHGLRDPLGAEEAAGHELAASPPPPLGPPEPSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETDSSTGSPTNLDKIAAQGRKRKKRTSIEVGVKGALENHFLKCPKPSAHEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPAGLPHPPMEDVYAQADTSPLHHALPGAVP
Protein: Thyroid hormone-inducible hepatic protein (Spot 14 protein) (S14) (SPOT14) (P04143)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:1446647}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Mid1-interacting protein 1
- Fatty acid synthase
- Insulin receptor
- BMP and activin membrane-bound inhibitor homolog
- Suppressor of cytokine signaling 3
- ATP-citrate synthase
- Mothers against decapentaplegic homolog 7
Sequence:
MQVLTKRYPKNCLLKVMDRYSAVVRNMEQVVMIPSLLRDVELSGSGGSVQDGAPDLYTYFTMLKSICVEVDHGLLPREEWQAKVAGNEGSEAENEAAETEEAEEDRLSEELDLEAQFHLHFSSLHHILTHLTQKAQEVTQKYQEMTGQVL
Protein: Ppp2r5d protein (Q921X5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
NSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQVTGPWGWGSTAGSREETGSRNGREGK
Protein: ARGOS-like protein (Q8RXL7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes cell expansion-dependent organ growth, probably via a brassinosteroids signaling pathway. Acts downstream of BRI1.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:21457262}.
Interaction partners:
- Methionine--tRNA ligase, cytoplasmic
- Protein ORGAN SIZE RELATED 1
- ADP-ribosylation factor
- Transmembrane protein
- ADP-ribosylation factor-like protein 2
- ADP-ribosylation factor
- Tubulin-folding cofactor D
- ADP-ribosylation factor C1
- Cytochrome P450 78A5
Sequence:
MIREFSSLQNDIINIQEHYSLNNNMDVRGDHNRKNTSFRGSAPAPIMGKQELFRTLSSQNSPRRLISASYFSLESMVVLVGLTASLLILPLILPPLPPPPFMLLLIPIGIMVLLMVLAFMPSSNSKHVSSSSTFM
Protein: GH16325p (Q8SXB1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLRKNQRALNKAMRDLDRERMKMEQQEKKIIADIKKMAKEGQMDAVKIMAKDLVRTRRYAKKFMLMKANIQAVSLKIQTLKSQNTMAQAMKGVTKAMQNMNRQLNLPQIQKILQDFEKQSEMMDMKEEMINDAIDDAMEDEGDEEETDAVVSQVLDELGLQLGEQLGDLPSASGSLSIAGGAGAQKAQAVAAGGVGGGGAAGGGGASGGGAGGPGAPGGSGASSPMSDADADLQARLDKLRKD
Protein: Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) (Q61644)
Organism: Mus musculus (Mouse)
Function: Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission.
Subcellular location: Cytoplasm. Cell projection {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse. Cytoplasm, cytosol. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Colocalizes with MAPT in axons. {ECO:0000250}.
Interaction partners:
- Actin nucleation-promoting factor WASL
- Dynamin-1
- Synaptojanin-1
- Protein kinase C and casein kinase II substrate protein 3
- Synaptojanin-2
- EH domain-containing protein 3
- Huntingtin
- Amphiphysin
- Protein kinase C and casein kinase substrate in neurons protein 2
- Actin nucleation-promoting factor WAS
Sequence:
MSGSYDEASEEITDSFWEVGNYKRTVKRIDDGHRLCNDLMSCVQERAKIEKAYAQQLTDWAKRWRQLIEKGPQYGSLERAWGAMMTEADKVSELHQEVKNSLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEERLAMTREMNSKTEQSVTPEQQKKLVDKVDKCRQDVQKTQEKYEKVLEDVGKTTPQYMEGMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYMHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTAKKEKQPKKAEGATLSNATGAVESTSQAGDRGSVSSYDRGQTYATEWSDDESGNPFGGNEANGGANPFEDDAKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI
Protein: Large ribosomal subunit protein uL30m (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (39S ribosomal protein L30, mitochondrial) (L30mt) (MRP-L30) (Q8TCC3)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Interaction partners:
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein mL41
- Large ribosomal subunit protein uL13m
- Mitochondrial ribosomal protein L40
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein uL22m
Sequence:
MAGILRLVVQWPPGRLQTVTKGVESLICTDWIRHKFTRSRIPEKVFQASPEDHEKYGGDPQNPHKLHIVTRIKSTRRRPYWEKDIIKMLGLEKAHTPQVHKNIPSVNAKLKVVKHLIRIKPLKLPQGLPAEENMSNTCLKSTGELVVQWHLKPVEQKAHES
Protein: Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) (Q28615)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (By similarity). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood. Has a critical role in renal dicarboxylate transport (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:P70545}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINSWGVPMFQLHTFPSWAHSNSTTHCLASPPTAPSP
Protein: Vacuolar protein sorting-associated protein 2 homolog 1 (AtVPS2-1) (Charged multivesicular body protein 2 homolog 1) (ESCRT-III complex subunit VPS2 homolog 1) (SNF7-like protein) (Q9SKI2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity).
Subcellular location: Endosome {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting-associated protein 32 homolog 2
- Vacuolar protein sorting-associated protein 32 homolog 1
- AMSH-like ubiquitin thioesterase 3
- Vacuolar protein-sorting-associated protein 37 homolog 1
- ESCRT-related protein CHMP1B
- ESCRT-related protein CHMP1A
- Vacuolar protein sorting-associated protein 24 homolog 1
- Vacuolar protein sorting-associated protein 20 homolog 1
- AMSH-like ubiquitin thioesterase 1
- Vacuolar protein sorting-associated protein 36
Sequence:
MMNSIFGKRKTPAELLRENKRMLDKSIREIERERQGLQTQEKKLINEIKKTAKQGQMGAVKVMAKDLIRTRHQIEKFYKLKSQLQGVSLRIQTLKSTQAMGEAMKGVTKAMGQMNRQMNLPSLQKIMQEFERQNEKMEMVSEVMGDAIDDALEGDEEEEETEDLVSQVLDEIGIDINQELVNAPSGAVAVPAAKNKVVQAEATGAEDSGGIDSDLQARLDNLRKM
Protein: Organic cation transporter protein (Q9VCA2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably transports organic cations.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Peptidase S1 domain-containing protein
- Metalloendopeptidase
Sequence:
MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQETAEEGGTQELSGMLNGKSG
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q27787)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MDTIDQFLETVGKGVCPRESEVMKLCNKARSILDGESNTHVIRAPCTIVGDIHAQFFDLIEMFRVGGDVPDLNYVFMGDYVDRGHHGVETFLLLLALKVKYTSRVALLRGNHESRQITQVYGFYDECLRKYGSVNVWRYCTDVFDLLPLVCVVEEKILCVHAGLSPMISTVSQMEAIERRCEVPHEGAMCDLLWSDPEEIEGWGLSPRGAGYLYGEDVVRTFLESNKLDLLCRSHQLVMEGYKVMFNDALVTVWSAPNYCYRCMNEKTNLELEQHLNKNFKLFEAAPDDARESSKPTVPDYFL
Protein: Plant heme peroxidase family profile domain-containing protein (Q38DK3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFRVYTRRLSSLGPFCGSRKCLLWWGYKEGDLHRIARQRPWWENAAIFAGLLCFIQASSMCYYFGNRWYQAIRPSGNDLYINRAMDTKVFSRPDLSVAAVRMVIHHALSGAQTPFGVPMVYPEYMKPEAEELMEFILQLNHEQPMFSIPDLWALFSAKALARLGGPSISVHRGRSDPPNDVPADQLLISTPSLVPESKRDVLNMKRLLSRQGFAVDEIVAMLGGIRNIGFHESSGFHTTEEVKPQMRRRPGVMGPEEDVYHIPDTPQKCTLDPYVFGSEYFDLLLDYNWKQNTSLFRRSGPFHCSENDRKREVLLLDPFSEQAMERERKRLQAEERARESVERAALKRHPSFDETTSITGGRDGEAQPISGVMSELNEDEGINVKSLVEVPEFKSPCSSVSMREVDVLLLDDALLTGWMHRFSANEILFYDVFGTVMEKIQCRGYNLNSLYLP
Protein: Internal alternative NAD(P)H-ubiquinone oxidoreductase A2, mitochondrial (EC 1.6.5.9) (Internal alternative NADH dehydrogenase NDA2) (NADH:ubiquinone reductase (non-electrogenic) NDA2) (O80874)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane.
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side {ECO:0000269|PubMed:21841088}. Peroxisome.
Interaction partners:
- Ubiquinol oxidase 1a, mitochondrial
- Ubiquinol oxidase 3, mitochondrial
- Ubiquinol oxidase 4, chloroplastic/chromoplastic
- Protein PROTON GRADIENT REGULATION 5
- Ubiquinol oxidase 1c, mitochondrial
- Ubiquinol oxidase 1b, mitochondrial
- GDSL esterase/lipase At1g28590
- Putative fructokinase-8
- Cytochrome P450, family 705, subfamily A, polypeptide 6
Sequence:
MFMIKNLTRISPNTSSIITRFRNSGSSSLSYTLASRFCTAQETQIQSPAKIPNDVDRSQYSGLPPTREGEKPRVVVLGSGWAGCRLMKGIDTNLYDVVCVSPRNHMVFTPLLASTCVGTLEFRSVAEPISRIQPAISREPGSFFFLANCSRLDADAHEVHCETLTDGLNTLKPWKFKIAYDKLVIASGAEASTFGIHGVMENAIFLREVHHAQEIRRKLLLNLMLSDTPGISKEEKRRLLHCVVVGGGPTGVEFSGELSDFIMKDVRQRYAHVKDDIHVTLIEARDILSSFDDRLRRYAIKQLNKSGVRFVRGIVKDVQSQKLILDDGTEVPYGLLVWSTGVGPSPFVRSLGLPKDPTGRIGIDEWMRVPSVQDVFAIGDCSGYLETTGKPTLPALAQVAEREGKYLANLLNAIGKGNGGRANSAKEIELGVPFVYKHLGSMATIGRYKALVDLRESKDAKGISMTGFVSWFIWRSAYLTRVISWRNRFYVAINWFTTFVFGRDISRI
Protein: Deubiquitinase and deneddylase Dub2 (ChlaDub2) (EC 3.4.22.-) (O84875)
Organism: Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx)
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease possesses deubiquitinating and deneddylating activities.
Subcellular location: Secreted {ECO:0000250}. Host cell {ECO:0000250}. Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Secreted, and delivered into the host cell. {ECO:0000250}.
Interaction partners:
Sequence:
MEPIHNPPPQTCSYSRPSTTYTSFKDASCGTKVTRIIIALFLIVISCGLILCAYTFRDLLDADYSAQEGPQQATKLLQQLDKVLTGPPLPIWDNEHLFQFSCLMQNKHRRVLPIDICNPLTKFNFLEYICNCLMTKQSVNVNETDMCELFCPPTCTPENYRRLLCTSSVFPFVMWHDPSADTQEAMLTKMDQTMSSGRVGNSHWVLVIVDIEHRCVTFFDSFYDYIASPQQMREQLEGLAASLGAIYPKEGGADSDQEELLSPFQVRIGSTVKVQSPGEFTCGAWCCQFLAWYLENPDFDLEEKVPTNPSERRALLADFISTTEQAMSRYSSLSWPTTD
Protein: Putative disease resistance RPP13-like protein 2 (Q9STE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential disease resistance protein.
Interaction partners:
- Protein kinase superfamily protein
- At5g50330
- Protein kinase superfamily protein
- Protein kinase superfamily protein
- Bromodomain transcription factor
- Transcription initiation factor TFIID subunit 8
- At3g02160
- Protein kinase superfamily protein
- RNA polymerase I specific transcription initiation factor RRN3 protein
- RNA polymerase I specific transcription initiation factor RRN3 protein
Sequence:
MVDAITEFVVGKIDNYLIEEAPMLIGVKDDLEELKTELTCIQVYLKNVEVCDKEDEVSKEWTKLVLDIAYDVEDVLDTYFLKLEKRLHRLGLMRLTNIISDKKDAYNILDDIKTLKRRTLDVTRKLEMYGIGNFNEHRVVASTSRVREVRRARSDDQEERVVGLTDDAKVLLTKLLDDDGDNKIYMISIFGMEGLGKTSLARKLFNSSDVKESFEYRVWTNVSGECNTRDILMRIISSLEETSEGELEKMAQQELEVYLHDILQEKRYLVVVDDIWESEALESLKRALPCSYQGSRVIITTSIRVVAEGRDKRVYTHNIRFLTFKESWNLFEKKAFRYILKVDQELQKIGKEMVQKCGGLPRTTVVLAGLMSRKKPNEWNDVWSSLRVKDDNIHVSSLFDLSFKDMGHELKLCFLYLSVFPEDYEVDVEKLIQLLVAEGFIQEDEEMTMEDVARYYIEDLVYISLVEVVKRKKGKLMSFRIHDLVREFTIKKSKELNFVNVYDEQHSSTTSRREVVHHLMDDNYLCDRRVNTQMRSFLFFGKRRNDITYVETITLKLKLLRVLNLGGLHFICQGYSPWSLPDVIGGLVHLRYLGIADTVVNNLPDFISNLRFLQTLDASGNSFERMTDLSNLTSLRHLTGRFIGELLIGDAVNLQTLRSISSYSWSKLKHELLINLRDLEIYEFHILNDQIKVPLDLVSLSKLKNLRVLKIEVVSFSLFSEETVRFELLVKLTLHCDVRRLPRDMDLIFPSLESLTLVTNLQEDPMPTLQKLQRLENLVLYSCVYPGAKMFINAQGFGRLRKLKVIIKRLDELEIEEEAMPCLMKLNLDNKDGATKLMIPDRMRAFV
Protein: Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (O08528)
Organism: Mus musculus (Mouse)
Function: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P52789}; Peripheral membrane protein {ECO:0000250|UniProtKB:P52789}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P52789}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane. The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein. Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis. {ECO:0000250|UniProtKB:P52789}.
Interaction partners:
- Non-selective voltage-gated ion channel VDAC1
- GDH/6PGL endoplasmic bifunctional protein
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Glucose-6-phosphate isomerase
- Fructose-2,6-bisphosphatase TIGAR
- ATP-dependent 6-phosphofructokinase, liver type
- ATP-dependent 6-phosphofructokinase, platelet type
- Glucose-6-phosphatase 3
- ATP-dependent 6-phosphofructokinase, muscle type
- Glucose-6-phosphatase catalytic subunit 1
Sequence:
MIASHMIACLFTELNQNQVQKVDQYLYHMRLSDETLLEISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVSDIEDDKDGIQKAYQILVRLGLSPLQEDCVATHRICQIVSTRSASLCAATLAAVLWRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLESLKLSHEQLLEVKRRMKVEMEQGLSKETHEAAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIRRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLDDLRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDKIRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR
Protein: Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) (Q15910)
Organism: Homo sapiens (Human)
Function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:12101246, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:9584199}. Note=Localizes to the inactive X chromosome in trophoblast stem cells. {ECO:0000250|UniProtKB:Q61188}.
Interaction partners:
- Polycomb protein SUZ12
- Histone-binding protein RBBP7
- Histone-binding protein RBBP4
- Polycomb protein EED
- DNA
- Histone deacetylase 1
- Polycomb complex protein BMI-1
- DNA
- Histone deacetylase 2
- Zinc finger protein AEBP2
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP