wanglab/gogpt-training-data huggingface dataset:
Protein: Hydroxyproline O-galactosyltransferase HPGT3 (EC 2.4.1.-) (Beta-1,3-galactosyltransferase 9) (Q5XEZ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q94F27}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Hydroxyproline O-galactosyltransferase GALT6
- Hydroxyproline O-galactosyltransferase GALT5
- Hydroxyproline O-galactosyltransferase GALT2
- Beta-arabinofuranosyltransferase RAY1
- Hydroxyproline O-galactosyltransferase GALT4
- Beta-glucuronosyltransferase GlcAT14C
- Beta-glucuronosyltransferase GlcAT14A
- Beta-1,6-galactosyltransferase GALT29A
- Fucosyltransferase 6
- Beta-glucuronosyltransferase GlcAT14B
Sequence:
MESLPTTVPSKSERRARSSKFSQSSSKPSVIMAFFSCVAWLYVAGRLWQDAENRVVLNNILKKSYDQKPKVLTVDDKLMVLGCKDLERRIVETEMELTLAKSQGYLKNLKSGSSSGKKLLAVIGVYSGFGSHLRRNTFRGSYMPQGDALRKLEERGIVIRFVIGRSPNRGDSLDRKIDEENQARKDFLILENHEEAQEELAKKVKFFFSAAVQNWDAEFYIKVDDNIDLDLEGLIGLLESRRGQDAAYIGCMKSGEVVAEEGGKWYEPEWWKFGDEKSYFRHAAGSLLILSKTLAQYVNINSGSLKTYAFDDTSIGSWMIGVQATYIDDNRLCCSSIRQDKVCSVA
Protein: Prolactin-5A1 (Placental prolactin-like protein L) (PLP-L) (PRL-like protein L) (Q9JII4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Prolactin receptor
- Pregnancy specific glycoprotein 19
- Tyrosine-protein kinase JAK2
- Pro-opiomelanocortin
- Carcinoembryonic antigen-related cell adhesion molecule 11
Sequence:
MQIQPHPSGALLLLLLSNLLMWENVASVPRCIMENGGCQKVLNYLFNMTSTISESFNTLSSETLNDFYTEFDPHQTFQNRPAMTCHTSSRSIPNNKRKAERMEPAALLNVIIRMLASWKNLLYHVENNMANLDGTPYAIISKVKLIDRQIKKLTKNLQDIKTILSQVHPELKEKENYPVWSGEPYVQKSKRRTQLFGLHSLFFCLYSDAEKVSDYVNILRNKIVPNE
Protein: RE53253p (Q7YU52)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MIISKDLFIFGEQIFATIIPEGGAAALATQQQHQQQHQQQHQQSHQQPHQQSQQQQQQQQPAIINSTTTTATSLVINSTAGAAEQVVEESLKVAAAAAAATTTTTAAAATTLPAKQETVAVAAACVAPRKLAKIQKIPKEPEELKAKKKAKCEAAAAATHYEKMPMNLMIVESVEAVDMGSSDNDNETTEQVPLVSASRRNLAKIVADCRLQIEVEPATSAVAAAAAAAASVASPPATSDATAATSVASSDSSASSSASSTSSSSSSSTSSEFTHTSQTTIPSTDNLTSSNGLANIGKSILVDAKSNSPASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHIDSGSVFLNREPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLV
Protein: F-box/WD repeat-containing protein 1A (Beta-TrCP protein E3RS-IkappaB) (Beta-transducin repeat-containing protein) (Beta-TrCP) (E3RSIkappaB) (mE3RS-IkappaB) (F-box and WD repeats protein beta-TrCP) (HOS) (Ubiquitin ligase FWD1) (pIkappaB-E3 receptor subunit) (Q3ULA2)
Organism: Mus musculus (Mouse)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (By similarity). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase (By similarity). Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF (By similarity). Required for proteolytic processing of GLI3. Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (By similarity). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11735228}. Nucleus {ECO:0000269|PubMed:11735228}.
Interaction partners:
- Glycogen synthase kinase-3 beta
- Cullin-1
- E3 ubiquitin-protein ligase RBX1
- Catenin beta-1
- S-phase kinase-associated protein 1
- Axin-1
- NF-kappa-B inhibitor alpha
- S-phase kinase-associated protein 2
- Period circadian protein homolog 2
- F-box/WD repeat-containing protein 7
Sequence:
MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCINQETVCLTSTAMKTENCVAKAKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDENAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNAGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLMAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAHAEPPRSPSRTYTYISR
Protein: Cellular tumor antigen p53 (B0S576)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU003304}. Nucleus {ECO:0000256|RuleBase:RU003304}.
Interaction partners:
- E3 ubiquitin-protein ligase Mdm2
- Transcriptional coactivator YAP1
- Cellular tumor antigen p53
- Ubiquitin-ribosomal protein eS31 fusion protein
- Tumor protein p53-binding protein, 1.
Sequence:
MSQSSTADEGPTFEHLWSTLEPDSTYFELPQAGHSGDRASSSLPGNRAEVCMDVYHMRDMRDMNDNVMSQYSLLSSSMDQGLGNRAASTSPYSSETTSNVPTPSPYSQPNSTFEAMSPAPAIPSNTDYPGPHNFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKLASSPPNGSVIRAMPIYKKAEHVTEVVKRCPNHELGRDFNESQTAPASHLIRVEGNNLCQYVDDPVTGRQSVLVPYESPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHFREQQALNESVAKNGNANKRNFKQTPTNITGPSINIKKRRHGEEEMYYIPVRGRENFDILMKIKDSLELVEFVPQQLVDSYRQQQQQLLQRQNHVASPSSYGTLNNMNKIHGPISKLPSVNQLVTQQTQQSAGPSASLSHMGANMLGGHHMQSNGDVNGAHQSQSIVSTSHCTPPPPYNPDPSLVSFLTSLGCQNCIDYFTSQGLQSVYHLQTLTMEDLGALKIPEQFRLAIWRGLQEMKQGHDYGQQLIRSSSNMATMAIGPSGELQRQRVMEAVHFRVRHTITIPNRGPANGPEEWPDFGFDMPDCRLHKHSIKEEFAEGDVH
Protein: Pancreatic alpha-amylase 2a5 (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) (P00688)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space.
Interaction partners:
- Glycogen phosphorylase, liver form
- Sucrase-isomaltase, intestinal
- 1,4-alpha-glucan-branching enzyme
- Glycogen phosphorylase, muscle form
- Glycogen phosphorylase, brain form
- Sucrase-isomaltase, intestinal
- Glycogen debranching enzyme
- Lysosomal alpha-glucosidase
- Neutral alpha-glucosidase C
- Alpha-amylase 1
Sequence:
MKFVLLLSLIGFCWAQYDPHTSDGRTAIVHLFEWRWVDIAKECERYLAPKGFGGVQVSPPNENVVVHNPSRPWWERYQPISYKICTRSGNEDEFRDMVTRCNNVGVRIYVDAVINHMCGAGNPAGTSSTCGSYLNPNNREFPAVPYSAWDFNDNKCNGEIDNYNDAYQVRNCRLTGLLDLALEKDYVRTKVADYMNHLIDIGVAGFRLDAAKHMWPGDIKAVLDKLHNLNTKWFSQGSRPFIFQEVIDLGGEAIKGSEYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGLVPSDRALVFVDNHDNQRGHGAGGSSILTFWDARMYKMAVGFMLAHPYGFTRVMSSYRWNRNFQNGKDQNDWIGPPNNNGVTKEVTINADTTCGNDWVCEHRWRQIRNMVAFRNVVNGQPFSNWWDNNSNQVAFSRGNRGFIVFNNDDWALSATLQTGLPAGTYCDVISGDKVDGNCTGLRVNVGSDGKAHFSISNSAEDPFIAIHADSKL
Protein: Possible oxidoreductase (O53772)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit A
- Uncharacterized protein Rv1405c
- Uncharacterized protein Rv1403c
Sequence:
MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMIDFWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVDVFRRMVGDDFTSLPRGDLAAAIYTTIEDQVETIFDDSIATIDEHRDGVRLTFERTAPRDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGYRPRDERSYVLYNTVDRQLARFALRGDRTMFLFVFRAEHDNPGVAPKDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRGRVLLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGGDHRRAFDAYEKRLRPFIEGKQASAAKFIWFFATRTRFGLWFRNVAMRTMNFGPLATLFAGSVRDDFELPDYTW
Protein: RING-type domain-containing protein (Q9N3T6)
Organism: Caenorhabditis elegans
Interaction partners:
- RNA helicase
Sequence:
MDVNEELPTCPVCQEEFDDQKAPFIISCGHSLCETCIVHLKSDYSDAYGSGGQTQCPTCRAVVSKEKRTKNFALTNAVTMIQKLREKPKKPANAVDCTQCTKYDNESDMFVCRNCVTDAFKYDVVENLGAEVDLDIKSLALCGSCALRSHVTQGHETVAYFPVASGMNFASQLTSISLLRIELESSFGLTNAWYARFASTYKTFHTELDKMTDMMRKSKSSDVQEEFSKRIDQEIKRMSDYVQSVCLEIANKDKEYQKSFTALVAINKKDEETKCQEPVEKIFELTCSECMTKQTVERFRCCKTCIEVVGKLVDNLLETTEIDAVDLETLPICTNCIVDHHHSDGEHKTVRYSQVQEAYTSLKVFSKVEKHKDEINIKFSALLDTFKHYITQLEGYDDKITKMSKIAMESRGHPEQAEVVKGFQNELEKADHAISSLQSNADMSQTVVRMQQKRLDAVENEFGTTSDA
Protein: LYR motif-containing protein 1 (O43325)
Organism: Homo sapiens (Human)
Function: May promote cell proliferation and inhibition of apoptosis of preadipocytes.
Subcellular location: Nucleus {ECO:0000269|PubMed:19022914}.
Interaction partners:
- Electron transfer flavoprotein regulatory factor 1
- LYR motif-containing protein 2
- LYR motif-containing protein 9
- Succinate dehydrogenase assembly factor 3, mitochondrial
Sequence:
MTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEARTLFRKNKNLTDTDLIKQCIDECTARIEIGLHYKIPYPRPIHLPPMGLTPLRGRGLRSQEKLRKLSKPVYLRSHDEVS
Protein: CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase) (Q9ULM6)
Organism: Homo sapiens (Human)
Function: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96LI5}. Nucleus {ECO:0000250|UniProtKB:Q96LI5}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q96LI5}.
Interaction partners:
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 2
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 8
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 6-like
- CCR4-NOT transcription complex subunit 11
- Protein PAT1 homolog 1
Sequence:
MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR
Protein: 40S ribosomal protein S3 (E9PSF4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGG
Protein: Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) (A0A0C4DGL3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
Protein: Arginine/serine-rich protein 1 (Q9BUV0)
Organism: Homo sapiens (Human)
Function: Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.
Subcellular location: Nucleus {ECO:0000269|PubMed:34042961}.
Interaction partners:
- Dual specificity protein kinase CLK2
- Dual specificity protein kinase CLK3
Sequence:
MSNYVNDMWPGSPQEKDSPSTSRSGGSSRLSSRSRSRSFSRSSRSHSRVSSRFSSRSRRSKSRSRSRRRHQRKYRRYSRSYSRSRSRSRSRRYRERRYGFTRRYYRSPSRYRSRSRSRSRSRGRSYCGRAYAIARGQRYYGFGRTVYPEEHSRWRDRSRTRSRSRTPFRLSEKDRMELLEIAKTNAAKALGTTNIDLPASLRTVPSAKETSRGIGVSSNGAKPELSEKVTEDGTRNPNEKPTQQRSIAFSSNNSVAKPIQKSAKAATEEASSRSPKIDQKKSPYGLWIPI
Protein: PR domain zinc finger protein 12 (EC 2.1.1.-) (PR domain-containing protein 12) (Q5U3V3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR037163}.
Interaction partners:
- Homeobox protein engrailed-like
- HMG box domain-containing 4a
- MCF.2 cell line-derived-transforming sequence a
Sequence:
MGSVLPADALVLKAGFKQQSLALSDIITSDILHSFLYGRWRNVLGEHLFEEKTATVSPKTAFTAEVLAQSFSGEVQKLSSLVLPSEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVISPEHVDLFKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGSSIFYKAVETIPPDQELLVWYGNSHNTFLGIPGVPGTEEEQQKKTKTDEFHLCDTVTAAALSTASRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCHVCQSAYSQLAGLRAHQKSARHRPANTGAVVGLQAHSPPPPQLAQVPHPASLVHHIPTMVL
Protein: Probable threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Q54J66)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Leucine--tRNA ligase, cytoplasmic
- Probable threonine--tRNA ligase 2, cytoplasmic
- Probable valine--tRNA ligase, mitochondrial
- Probable valine--tRNA ligase, cytoplasmic
- Tryptophan--tRNA ligase, mitochondrial
- Probable methionine--tRNA ligase, cytoplasmic
- Large ribosomal subunit protein uL11m
- Tryptophan--tRNA ligase, cytoplasmic
- Probable cysteine--tRNA ligase, mitochondrial
- Large ribosomal subunit protein uL22m
Sequence:
MSDSQENKPVETPTEVKPVAEKKPAAEKKEKKPAVKKVGVMETLQTPDYVKERIEIWESLKAKHLESLKDMKEEPINVTLPDGKVVAGIKNKTTPYDIAKGISRGLADSIVSSKVNGEQIWDISRPLEADCNLQLCKFDSEEGKKTFWHSSAHILGQAMERIYGGQLCIGPATSEGFYYDMAMGDKIVSAEDYKLINEVAQKIVQEKQPFERLAVPRDIALTMFKFNKYKTEIISKIPQEDTVSLYRCGTLVDLCRGPHVPNTSYIKSFAVTKNSSAYWLGKAENDDLQRVYGISFPDKKQMEEYENFMREAALRDHRNVGKAQELFFFHPYSPGSAFFLPHGTRIYNKLVEFIREEYHRRGFTEVISPSIFSQKLWEQSGHWQKYSENMFVLPVDKDNFSLKPMNCPGHCLMFGSRQRSYRELPLRFADFGVLHRNELAGALTGLTRVRKFQQDDAHIFCTTEMIEDEINSCLGFMQYVYGIFGFEFGLELSTRPDNFLGEIAQWDIAEASLEKALNKFGKPWKLNPKDGAFYGPKIDIHITDCLKRSHQCATIQLDFQLPIRFDLEYQSDDAAELKKRPVIIHRAILGSVERMMAILIEHTGGKWPLWVSPRQAIVVTVNKTHNEYGQKVCKEISDAGFYCDIDDSDKTISKKVREAQLAQYNYILVVGQEEINGNTVNVRTRDNVVRGSLTVNDLISEFKQLVKEFK
Protein: Vezatin (Q9HBM0)
Organism: Homo sapiens (Human)
Function: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15090598}; Multi-pass membrane protein {ECO:0000305}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q3ZK22}. Cell junction, adherens junction {ECO:0000269|PubMed:15090598}. Nucleus {ECO:0000250|UniProtKB:Q3ZK22}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q3ZK22}.
Interaction partners:
- Unconventional myosin-VIIa
- Whirlin
- Usherin
- Adhesion G-protein coupled receptor V1
- PDZ domain-containing protein 7
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL23
- Harmonin
Sequence:
MTPEFDEEVVFENSPLYQYLQDLGHTDFEICSSLSPKTEKCTTEGQQKPPTRVLPKQGILLKVAETIKSWIFFSQCNKKDDLLHKLDIGFRLDSLHTILQQEVLLQEDVELIELLDPSILSAGQSQQQENGHLPTLCSLATPNIWDLSMLFAFISLLVMLPTWWIVSSWLVWGVILFVYLVIRALRLWRTAKLQVTLKKYSVHLEDMATNSRAFTNLVRKALRLIQETEVISRGFTLVSAACPFNKAGQHPSQHLIGLRKAVYRTLRANFQAARLATLYMLKNYPLNSESDNVTNYICVVPFKELGLGLSEEQISEEEAHNFTDGFSLPALKVLFQLWVAQSSEFFRRLALLLSTANSPPGPLLTPALLPHRILSDVTQGLPHAHSACLEELKRSYEFYRYFETQHQSVPQCLSKTQQKSRELNNVHTAVRSLQLHLKALLNEVIILEDELEKLVCTKETQELVSEAYPILEQKLKLIQPHVQASNNCWEEAISQVDKLLRRNTDKKGKPEIACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQADGSGLTTAPPTPRDSLQPSIKQRLARLQLSPDFTFTAGLAAEVAARSLSFTTMQEQTFGGEEEEQIIEENKNEIEEK
Protein: Photorhabdus luminescens subsp. laumondii TTO1 complete genome segment 7/17 (Q7N5I7)
Organism: Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) (Photorhabdus luminescens subsp. laumondii)
Interaction partners:
- Photorhabdus luminescens subsp. laumondii TTO1 complete genome segment 7/17
Sequence:
MSESIISQKEIQYPKVNIKSLDETVNKIWLLAKQQTSGITAIAEKAERVSSYSRELSELVSESLSKLPPILSQFLAGDIFQSIRKIDKALEAHDLSDEKRSDILKARDQFIQKLSKDIDNVIANFDDRINKLTGKINDINDIVIAGHFEDVLAKTKKQKAELQSDIEQKTKERKKLDAERDKIIESQDVIRAKNIADMFKDYLPNTNDIDGLNFAQPEKEIIKQSIEIVKKVLGKISEGLKYIDLENARMKLTEQIDHTMQESKALKTTLEETELRLSGLKDVMQIDTERTTMLNEVGKLEKAWRLFSSQLHELSDKNINQDYLTNLINGQLNFLDNLVISI
Protein: Protein tyrosine phosphatase, receptor type, K (A0A8J8XMU1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
CVCVHACVCAFVRVLYRPSPCSSLPFQGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMVVDSSNHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVKFLVCAFLKYNTGSAGVVSLPCSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESRADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDGTLMFIISGGGGGRGLRGPRMTSFLH
Protein: Solute carrier family 13 member 2 (Intestinal sodium/dicarboxylate cotransporter) (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (P70545)
Organism: Rattus norvegicus (Rat)
Function: Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood. Has a critical role in renal dicarboxylate transport (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:9691021}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sulfate transporter
Sequence:
MATCWPALWAYRFYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIVLFPLMGIMDASEVCIEYFKDTNILFVGGLMVAIAVEHWNLHKRIALQVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQGSKKDVEGGNNNPTFELQEECPQKEVTKLDNGQPVSAPSEPRTQKTQEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSLFPQNGNVVNFASWFGFAFPTMIILLLLAWLWLQVLFLGVNFRKNFGFGEGEEERKQAAFQVIKTQYRLLGPMSFAEKTVTVLFVLLVVLWFTREPGFFPGWGDTVFANEKGQSMASDGTVAIFISLVMFIIPSKIPGLMQDPKKPGKLKAPPAILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQHIPPSATAVILCLLIAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITLSINSWSIPIFKLDTFPSWAHSNTSQCLLNPSNSTVPGGL
Protein: Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD(+)-specific ICDH) (P28241)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:11502169}.
Interaction partners:
- Isocitrate dehydrogenase subunit 1, mitochondrial
- Aconitate hydratase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- Citrate synthase, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- Isocitrate dehydrogenase
Sequence:
MLRNTFFRNTSRRFLATVKQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL
Protein: F-box and leucine-rich repeat protein 13 (Dynein regulatory complex subunit 6) (F-box/LRR-repeat protein 13) (Q8NEE6)
Organism: Homo sapiens (Human)
Function: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8JHD7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29348145}.
Interaction partners:
- S-phase kinase-associated protein 1
- Centrin-2
- Cullin-1
- Centrosomal protein of 152 kDa
- Centrin-3
- Dynein regulatory complex subunit 3
Sequence:
MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHWHSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKWKNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALELTVKKSTYSSEDQAA
Protein: Large ribosomal subunit protein P2A (60S acidic ribosomal protein P2A) (P2) (P46252)
Organism: Zea mays (Maize)
Function: Plays an important role in the elongation step of protein synthesis.
Interaction partners:
- 60S ribosomal protein L36a
- 60S ribosomal protein L5-1
- 60S ribosomal protein L44
- 60S ribosomal protein L3-1
- 60S ribosomal protein L27a-3
- 60S ribosomal protein L39
- Putative inactive leucine-rich repeat receptor-like protein kinase
- 60S ribosomal protein L27a-2
- 60S ribosomal protein L13a-1
- 60S ribosomal protein L13a-1
Sequence:
MKFVAAYLLAVLAGNASPSADDLTAILESVGCEVDNEKMELLLSQLSGKDITELIAAGREKFASVPCGGGGVAVAAAAPAAGGAAPAAEAKKEEKVEEKEESDDDMGFSLFD