wanglab/gogpt-training-data huggingface dataset:
Protein: Cystine transporter (ERD suppressor) (Transmembrane protein ERS1) (P17261)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from vacuoles/endodomes.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:15885099}; Multi-pass membrane protein {ECO:0000269|PubMed:15885099}. Vacuole membrane {ECO:0000269|PubMed:15885099}; Multi-pass membrane protein {ECO:0000269|PubMed:15885099}.
Interaction partners:
- Protein ERD1
- Protein MEH1
- Vacuolar histidine transporter YPQ3
- Vacuolar lysine transporter YPQ1
- Vacuolar arginine/histidine antiporter YPQ2
- UPF0587 protein YCR090C
- Rhomboid-type serine protease 2
Sequence:
MVSLDDILGIVYVTSWSISMYPPIITNWRHKSASAISMDFVMLNTAGYSYLVISIFLQLYCWKMTGDESDLGRPKLTQFDFWYCLHGCLMNVVLLTQVVAGARIWRFPGKGHRKMNPWYLRILLASLAIFSLLTVQFMYSNYWYDWHNSRTLAYCNNLFLLKISMSLIKYIPQVTHNSTRKSMDCFPIQGVFLDVTGGIASLLQLIWQLSNDQGFSLDTFVTNFGKVGLSMVTLIFNFIFIMQWFVYRSRGHDLASEYPL
Protein: Neuron navigator 2 (A0A8I5ZQM9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MESISESSQQQKRKPVTHGLEDQKRIYTDWANHYLAKSGHKRLIKDLQQDVTDGVLLAQIIQVVANDKIEDINGCPKNRSQMIENIDACLNFLAAKGINTQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQQQPEKQHLSSSPLPPAGSQVAGAPSQCQSGILQQQGLATPQAPCQPLQPASHQQAKTQAEMQSRLPGPTARVAAAGSEAKTRGGSTAANNRRSQSFNNYDKSKPVPSPPQPAPPSNHEKEPLASSASSHPGMSENVPASLESSPSIPVNCSSSAIPQPSMTSKPWRSKSLSVKHSATSSMLSVKPAGPEAPRPTPEAMKPAPNNQKSMLEKLKLFNSKGGSKAGEGSASRDTSCERLEILPSFEESEELEVANRAPPTAGPASSSPKIALKGIAQRTFSRALTNKKSSPKGNEKEKEKQQREKEKETGKDLTKRVSVTDRPDLKEEPKEELSGVVVTEMPKKSSKIASFIPKGGKLSSTKKEATAPSHSGIPKPGMKNMPGKSPSAPIPPKEGERSRGKLSSGLPPQKPQLDSRHSSSSSSLASSEGKGPGGTTLNHSISSQTVSGSIGTTQTTGSNTVSVQLPQPQQQYSHPNTATVAPFLYRSQTDTEGNVTAESSSAGVSMEPSHYTKSGQPALEELTEDPEARRLRTVKNIADLRQNLEETMSSLRGTQVTHSTLETTFDTNVTTEISGRSILSLTGRPTPLSWRLGQSSPRLQAGDAPSMGNGYPPRANASRFISAEAGRYVYSAPLRRQLASRGSSICHVDVSDKVGDEVDLEGISMDAPGYMSDGDVLSKNIRTDDITSGYMTDGGLGLYTRRLNRLPDGMAVVRETLQRNTSLGLGDADSWDDSSSVSSGISDTIDNLSTDDINTSSSISSYANTPASSRRNLDVQTDAEKHSQVERNSLWSGDDIKRSDGGSDSGVKMEPGSKWRRNPSDMSDESDKSVSGKKNPVLSQTGSWRRGMTAEVGITMPRTKPSAQTGTLKTSGTGKTDDAKVSEKGRLSPKASQVKRSPSDAGRSSGDESKKTLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGATVTSRSATLGKIPKSSALVGRSTGRKTSMDGAPNQDDGYLSLSSRTNLQYRSLPRPSKSNSRNGAGNRCSTSSIDSNMSSKSAGLPVPKLREPSKTSLGSSLPGLVNQTDKEKGISSDNESVASCNSVKVNPATQPVSNSTQATLQPGTKYTDVASPTLRRLFGGKPTKQVPIATAETMKSAVVISNPHATMTQQGNLESPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHSGPSNSLTWGTSSSAVSKDGLGFQSVSSLHTSCESIDISLGSGGGLSHNSSPGPVASTKEDSLMPFVRTSSVKTTLSESPLSSPAASPKFCRSTLPRKQDSDPHLDRNTLPKKGLRYTPTSQLRTQEDTKEWFRSHSAGGLQETATNSPFSSGSSVTSPSGTRFNFSQLASPTAVTQMSLSNPTMLRTHSLSNADGQYDPYTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEEVHGSSLSLVSSTSSIYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAHLVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINTPELNCKGNGSAQATDLRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNWVNELRSSFKQAFGKKKSPKSASSHSDIEEMTDSSLPSSPKLPHNGSTGSTPLLRNAHSNSLISECMDSEAETVMQLRNELRDKEMKLTDIRLEALSSAHQLDQLREAMNRMQSEIEKLKAENDRLKSESQGSGCSRAPSQVSISASPRQSLGLSQHSLNLTESTSLDMLLDDTGECSARKEGGRHVKIVVSFQEAMKWKEDSRPHLFLIGCIGVSGKTKWDVLDGVVRRLFKEYIIHVDPVSQLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTTILVTVKGLTENSLDSLVFESLIPKPILQRYVSLLTEHRRIILSGPSGTGKTYLANRLSEYVVLREGRELTDGVIATFNVDHKSSKELRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIFNGLLNCKYHKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGFLGRFLRRKLMETEISGRVRNAELVKIINWIPKVWHHLNRFLEAHSSSDVTIGPRLFLSCPIDVDGSRVWFTDLWNYSIIPYLLEAVREGLQLYGRRAPWEDPAKWVMDTYPWAASPQQHEWPPLLQLRPEDVGFDGYSLPREGSTSKQVPPSDTEGDPLMNMLMRLQEAANYSSPQSYDSDSNSNSHHDDILDSSLESTL
Protein: BBG-LP29 (Q15K33)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYRLQRRTALITKQDLGTLSNHHSNISSISGINASSNIPAATLISSSIKKTSTEAATTKPAAPQIPGKMELLSSNTGTTTTTTTATHHLHQATTTKQLLVQDYLSYASPPTYSRLPPDGHEFPPNFSEPLIMHSHPLKVTTELSYEIQKGGKDESSAPPLPKTGPPATVPRKVYRQDLVINVEPAPSLTRDYQRSLSGGTPRKPSDWRKDEKSEKSVRDKIAMFSSNNELDAIPPAP
Protein: Zinc finger protein ZPR1 (Q9W379)
Organism: Drosophila melanogaster (Fruit fly)
Function: Might mediate EGFR and FGFR signal transduction cascades required for lumen formation in tracheal cells.
Interaction partners:
- CKII-alpha subunit interactor-1
- Uracil phosphoribosyltransferase homolog
- Nucleolar complex protein 2
- DNA-directed RNA polymerase I subunit RPA1
Sequence:
MSTVSDPNSSNPPESAGNIRPEPIFREINAEQTDEIVEVESACMNCFETGVTRLLPTKIPFFREVVLMSFKCDHCGHINNEMQSASEIQKSGIRIELRVQSVADLNRRVVRSDNSSISIPEIELEIPVQSQKGEVTTVEGIIERTIAGLSQDQEKRRIDHPETAASIEKYIERLHRLKEVTTPFQVLLEDISGNSFIENPLAPAADPQLKTSYFTRSQQQNEQLGLYEQNHEEQHLLKPIAEDSWPIENLHGEVLQFPTNCPSCQAPCETNMKLTNIPHFKEVVIMATVCGACGHKTNEVKSGGGVEAQGVRFRVQIASREDLTRDVLKSETCSMSIPELDLEVGPHALCGRFTTVEGLLVAMRDQLDGTLFHDSADDATKQQMQRFLDTFEDVMNLKRVITLVLEDPAGNTYVQSLSDDDSEPDDKLTVERYDRSYEDNEDLGLNDMKTEGYEEKA
Protein: Zinc-regulated transporter 1 (High-affinity zinc transport protein zrt1) (O94639)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: High-affinity zinc transport protein. Regulates intracellular zinc levels.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Low-affinity iron/zinc ion transport protein fet4
- Zinc homeostasis factor 1
- Probable zinc transporter zrg17
- Zinc finger protein C25B8.19c
- Putative inorganic phosphate transporter C8E4.01c
- Metallothionein zym1
- VEL1-related protein SPBPB2B2.15
- Uncharacterized mitochondrial carrier C1682.09c
- VEL1-related protein SPBC1348.06c
- Adenosine 5'-monophosphoramidase hnt1
Sequence:
MSLNNLSNSYNQYLAQESHQILRHLFLNKQYSPLVKRDDDSSATVTCGGDANEFNEYGHLGYRIGAIFVILATSLIGMNLPLVLSKITKNRPNVYIEYLYLFARYFGSGVILATAFIHLLAPACNKLYDPCLDDLFGGYDWAPGICLISCWFILLLEVLLNRYVEWRFGMEIGDHHGPTLGAKQHSHSHEDGAHGVHEHPVYDIEECADGVEHECVKDDLEEVKLEPYTNTDSTDLTTKEEARSFLLKQQLTAFIILESSIILHSVIIGLTTAVSGEEFKTLFPVIIFHQAFEGCGLGSRLAGMAWGPKTAWVPWVLGVIYSLVTPIGMAAGLGVREHWDPLAHGSYAAQGVLDAISSGILVYAGLVELLAHDFLFSPERERNWYKLIYLLACSMAGTGVMALLGKWA
Protein: Cochlin (COCH-5B2) (O43405)
Organism: Homo sapiens (Human)
Function: Plays a role in the control of cell shape and motility in the trabecular meshwork.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12843317, ECO:0000269|PubMed:22610276}.
Interaction partners:
- Beta-tectorin
- Solute carrier family 22 member 17
- Ubiquitin-like protein FUBI
- Syntaxin-binding protein 6
- Choline transporter-like protein 2
- Alpha-tectorin
Sequence:
MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ
Protein: Putative oxidoreductase TDA3 (EC 1.-.-.-) (Batten disease protein 3) (Topoisomerase I damage affected protein 3) (P38758)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Putative oxidoreductase that negatively regulates the retrieval of cargo from late endosomes to the Golgi. Regulates YIF1 and KEX2 localization. Required for fast DNA replication.
Subcellular location: Cytoplasm. Late endosome. Note=The recruitment from the cytoplasm to endosomal structures is facilitated by BTN2.
Interaction partners:
- Apoptosis-inducing factor 1
- Small ribosomal subunit protein mS41
- Uncharacterized membrane protein YGR016W
- DASH complex subunit DAD4
- Aminomethyltransferase, mitochondrial
- Protein BTN2
- Uncharacterized protein YMR085W
- Probable serine/threonine-protein kinase RTK1
- Glutamine synthetase
- Homeostatic regulator of DAG
Sequence:
MGEDFMHPPFQTYPSKNSEGKKHIVIVGGGIIGCCTAYYLTQHPSFSPSTHHITIIESRRIAGGASGKAGGLLASWAFPHQIVPLSFQLHQELSDEYDGENNWDYRRLTTVSLEADVREEVIENYERLSKKAYNLNVPPPKKRPGYISNKFNIGDSNSSLSSSGSSLKNDSASNEEEGSDIHVSSSVPSLHSLTNERMRSHTNSASDLDSVSPVEQLRETNIHNPLPADLDWIRRELVNDWSSLGGTDTTAQLHPYKFTHFILSKAMETGAVDLLLGKVVGLKCDEMDCVHSLKYLPSVVKNRRNSRGHAENPDIKLGTIFNDENAKPIEINDIQQIVLSMGPWTSKILKDCPISGLRAHSVTIKPSEKTVSPYAILAELKVNDREFFSPEMYARKDEVYVCGEGDTLVNIPESSDDVEVVSEKCDELYHYVSKLSPTLSKGHLLRKQACFLPVLNVPTSSGPLIGETNVKDLYIASGHSCWGINNAPATGKLMAEILLDGEATSAEISSLDPKLYFDATILS
Protein: Glycerophosphocholine acyltransferase 1 (GPCAT) (EC 2.3.1.-) (P48236)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA. Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA. In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC. Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1. Involved in postsynthetic PC remodeling that produces more saturated PC species.
Subcellular location: Membrane {ECO:0000269|PubMed:12524434, ECO:0000269|PubMed:18430972}; Multi-pass membrane protein {ECO:0000269|PubMed:12524434}.
Interaction partners:
- Lysophospholipid acyltransferase
- Glycerophosphoinositol transporter 1
Sequence:
MYKLDNNDIDDETNNSVSLTSLLEFLDPIASKVVSKYYHGSHLSKAEQKLRNFEGFRRRKPHHEHDSHHPHHLNRSRSFLQLEDFKVRALQRIRNLDKPLDSIFFKNSSRLEKAFYPFTLFNIFFIGFLMGRFPEWFHVYYTILFFVLMPIRFYTYYKTKNHYFLADFCYFVNMLCLLFIWIFPYSYSLFQSCFAFTFGTLCFAVITWRNSLVIHSIDKTTSCFIHIIPPCVMYVIYHGLPLEYKIERFPGAIIQSELDIKKNILWTSLYYLVWQSLYHYFITLKKSSKIKSGERMTSFEYLTTHQFKNFWAVKLRSPWPMIIYTLSQYFYQLFTMLLCGIWIRYKLAAALFLTIVFLWASHNGATYYIDHYGKNFEKEVDRLRLEVENLQQKLQPDSDAVISDASVNDKDYLNVNRDEDFDDSSSVSSKSD
Protein: Expansin-A3 (AtEXPA3) (Alpha-expansin-3) (At-EXP3) (AtEx3) (Ath-ExpAlpha-1.9) (O80932)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found (By similarity).
Subcellular location: Secreted, cell wall. Membrane; Peripheral membrane protein.
Interaction partners:
Sequence:
MTATAFRVGLWLAVTASFLLTATNAKIPGVYSGGPWQNAHATFYGGSDASGTMGGACGYGNLYSQGYGVNTAALSTALFNNGFSCGACFEIKCTDDPRWCVPGNPSILVTATNFCPPNFAQPSDDGGWCNPPREHFDLAMPMFLKIGLYRAGIVPVSYRRVPCRKIGGIRFTVNGFRYFNLVLVTNVAGAGDINGVSVKGSKTDWVRMSRNWGQNWQSNAVLIGQSLSFRVTASDRRSSTSWNVAPATWQFGQTFSGKNFRV
Protein: E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) (Q96PU5)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes. Involved in the regulation of TOR signaling. Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF. Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:18819914, ECO:0000269|PubMed:27694961}. Golgi apparatus {ECO:0000269|PubMed:26363003}. Endosome, multivesicular body {ECO:0000269|PubMed:26363003}. Note=May be recruited to exosomes by NDFIP1.
Interaction partners:
- Serine/threonine-protein kinase Sgk1
- Mothers against decapentaplegic homolog 7
- Ubiquitin-conjugating enzyme E2 D2
- Mothers against decapentaplegic homolog 3
- Epithelial sodium channel subunit beta
- Epithelial sodium channel subunit alpha
- Epithelial sodium channel subunit gamma
- Polyubiquitin-C
- Angiomotin
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Protein: Syndecan (P49415)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cell surface proteoglycan that bears heparan sulfate. Required for axonal and myotube guidance, is a necessary component of slit/robo signaling and is required in the slit target cells.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Dally-like, isoform A
- Tyrosine-protein phosphatase Lar
- Fibroblast growth factor
- Roundabout 1, isoform A
- Division abnormally delayed protein
- Roundabout 2, isoform B
- Protein slit
- Heparan-sulfate 6-O-sulfotransferase
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase
- LP22668p
Sequence:
MKPKQKISVEPLLLVAILIGVLVAATHAQDQKSVKPSAAAPSAAASRPHDEIYIDDDSIEGSGGRGGIHEDLEKDPDYSGSGFGPDDEDAEPDQHSHSSHNTRISQSSNSGINTAHTPTQTSSTIPTTSTSTPMPTTTPTATTPASTTTAAATQISSFANSSSTTTTTLAPTIPAEPQQPLFPPFDKDLDTESSGDGIDADAEDDDEDDGDDKDYDYNKELDKEIDIDGPEPGHLPPVVHHNTVETGHIPTTDEIDVDGGDEDDNGDSDIDGPRIGGNDGDITERGPGAGGSNVHELDPNTNVNSQPSDTKGIDHRPNGNEVVIMSEDDRTSSFFSQPGILAAVIGGAVVGLLCAILVVMFIVYRMRKKDEGSYALDEPKRSPANNSYAKNANNREFYA
Protein: Translin (Component 3 of promoter of RISC) (Q7JVK6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- FI16517p1
- Protein argonaute-1
- Elongator complex protein 1
- Endoribonuclease Dcr-2
- Nuclear cap-binding protein subunit 2
Sequence:
MSNFVNLDIFSNYQKYIDNEQEVRENIRIVVREIEHLSKEAQIKLQIIHSDLSQISAACGLARKQVELCAQKYQKLAELVPAGQYYRYSDHWTFITQRLIFIIALVIYLEAGFLVTRETVAEMLGLKISQSEGFHLDVEDYLLGILQLASELSRFATNSVTMGDYERPLNISHFIGDLNTGFRLLNLKNDGLRKRFDALKYDVKKIEEVVYDVSIRGLSSKEKDQQEEPAVPATE
Protein: Prefoldin subunit 2 (A1A4P5)
Organism: Bos taurus (Bovine)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9UHV9}. Cytoplasm {ECO:0000250|UniProtKB:Q9UHV9}. Mitochondrion {ECO:0000250|UniProtKB:Q9UHV9}.
Interaction partners:
- Prefoldin subunit 5
- Prefoldin subunit 3
- Prefoldin subunit 6
- Prefoldin subunit 1
- Prefoldin subunit 4
- p53 and DNA damage-regulated protein 1
- RNA polymerase II-associated protein 3
- Prefoldin subunit 4
- Protein UXT
- RuvB-like helicase
Sequence:
MAENGGRAGKSSGSGTGKGAVSAEQVIAGFNRLRQEQRGLASKAAELEMELNEHSLVIDTLKEVDETRKCYRMVGGVLVERTVKEVLPALENNKEQIQKIIETLTQQLQAKGKELNEFREKHNIRLMGEDEKPAAKENSEGAGAKASSAGVLVS
Protein: CD33 molecule (cDNA FLJ50122, highly similar to Myeloid cell surface antigen CD33) (B4DF51)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MPLLLLLPLLWADLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTHPTTGSASPVSDGASWHPVCPADTSSQCGPPSCPIQHFQN
Protein: HTH-type transcriptional repressor FabR (P0ACU5)
Organism: Escherichia coli (strain K12)
Function: Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Fatty acid metabolism regulator protein
- 3-oxoacyl-[acyl-carrier-protein] synthase 1
- Inner membrane protein YijD
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
- Glycerol-3-phosphate acyltransferase
- Met repressor
- UPF0208 membrane protein YfbV
- Negative modulator of initiation of replication
- UPF0352 protein YejL
- Regulator of ribonuclease activity B
Sequence:
MFILWYSASSTFGKDSDIVMGVRAQQKEKTRRSLVEAAFSQLSAERSFASLSLREVAREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRAFTEAQAEAMVTIVFSAGAEALDVGVEQRRQLEERLVLQLRMISKGAYYWYRREQEKTAIIPGNVKDE
Protein: Sperm associated antigen 9 (A0A8I6A5S1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MNPGCMLLFVFGFVGGAVVINSAILVSLSVLLLVHFSISTGVPALTQNLPRILRKERPISLGIFPLPAGDGLLTPDTQKGGETPGSEQWKFQELSQPRSHTSLKVSHSPEPLKAVEQEDELSDISQGGSKATTPASTANSDVSAIPPDTPSKEDNEGLVKGTDTPNKAEISKHIEVQVAQETRNVSTDSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNVVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNAAKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVANGQGENKMKNLPVPVYLRPLDEKDASMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVSALESEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSQVWICTSTHSTTKVIIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEELSDSGQVDRASLCGSMTSNSSAEMDSLLGGITVVGCSTEGVTGAAASPSTNGASPVIEKPPEVEAENSEIDENIPTAEEATEATEGNAGSTEDAVDISQPGVYTEHVFTDPLGVQIPEDLSPVFQSSNDSDVYKDQISVLPNEQDLAREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGLDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGTPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVVSPQSSSSGADLTADKAGSSAQEPSSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMCGNE
Protein: Tegument protein UL47 (P30021)
Organism: Bovine herpesvirus 1.1 (strain P8-2) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Function: Tegument protein that can bind to various RNA transcripts. Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase UL41/VHS. Also plays a role in the primary envelopement of virions in the perinuclear space, probably by interacting with two nuclear egress proteins UL31 and UL34.
Subcellular location: Virion tegument {ECO:0000250|UniProtKB:P10231}. Host nucleus {ECO:0000250|UniProtKB:P10231}. Host cytoplasm {ECO:0000250|UniProtKB:P10231}. Note=Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus. {ECO:0000250|UniProtKB:P10231}.
Interaction partners:
Sequence:
MDAARDGRPERRPRRSGTYRTHPFQRPSARRSLLDALRAADAEAAERPRVRRPRPDFQRPPDEDTSEDENVYDYIDGDSSDSADDYDSDYFTANRGPNHGAGDAMDTDAPPERAPEGGAPQDYLTAHLRAIEALPESAPHRSLLERTARTVYAHEFPPRDLSAGSRAPAQRARRSLRGFPRGGGGGQEPGPDDEGDDAADLREDLVPDEAYAHLERDERLSEGPPLLNMEAAAAAAGERSVVEELFTYAPAQPQVEVPLPRILEGRVRPSAFFAQMPLDALCRTPPNDQRVVRERRAWDMAGTPHGLLITTWSTVDPEFSIGGMYVGAPEGTRPRLVWRRAMKQAMALQYRLGVGGLCRAVDGARMPPTEALLFLAARAAARSAQLPFFVAAGARGRRRAAPARGGGWAAGSHAVHATGRVPHATLFRGSMGSLIYWHELRVMLTAVPALCARYAGAGLQSAELYLLALRHSEAPGYTANERYALSAYLTLFVALAERAVRWLYLAGAHLLGPHPTAAAFREVRAKIPYERLPLGSATLHDAEVETVDSATFQEALAFSALAHVYGEAYVAVRTATTLLMAEYAAHAERRDVREMTAAFLGVGLIAQRLMGSLEPAAELRSRRSGVRGPACPTVREGTLARYSLLADAALPLVRPVSLVEFWEARDGVMRELRLRPVASPPLAGKRRVMELYLSLDSIEALVGREPLGSRPVLGPLVDIAEALADHPHLVTGDGRGPRLGGR
Protein: Splicing factor pTSR1 interacting protein (Q9U5J1)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MDAIPPEYDKDTKERIYRQEWLEYFNYIGWDRAVSEHPEQYYSIFPGGHHHALHNMNNGGSVMGDIMGKQENIGSIGVSAPILGNQRPAGGASYRAGILAPPVMTTASAAAKMFLDDGSSSGSDGDSRYSSRSSSSSSDASSLDGSKERDGEVNRGQRRYERAAEAGASEADTKKSASNRRRHRSGSGTKRRSRSRHRHRDKSRRRSTNNDKKSGRKRERSKDAEESRARRDDKPPRNEQKTGRRDERRERDNKHRSNDRDERRHHHHRSDKPHGSEHGRNRDRERDRERERERDRDRGRERERERDWDRRKEKAPAGGGSSNGSRSHKGHYILHEGNDKFRGRGDGSISAGGDRYDDRREDARQRRQRDEGRYRR
Protein: Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP-responsive element modulator in testis) (Activator of CREM in testis) (Q5TD97)
Organism: Homo sapiens (Human)
Function: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
Subcellular location: Nucleus {ECO:0000269|PubMed:11327716}. Note=Nuclei of round and elongated spermatids.
Interaction partners:
- cAMP-responsive element modulator
- Dynein axonemal light chain 4
- Kinesin-like protein KIF17
Sequence:
MTTAHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFICFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDTDI
Protein: Ribonuclease H2 subunit B (Ribonuclease HI subunit B) (Q8N451)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAGVDCGDGVGARQHVFLVSEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSRVQSTAFFSGDQASTDKEKDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKKNSKMTAAQKALAKVDKSGMKSIDTFFGVKKKLERFETLKIKSSKNICFLHVSVCPS
Protein: MAP6 domain-containing protein 1 (21 kDa STOP-like protein) (SL21) (Q14BB9)
Organism: Mus musculus (Mouse)
Function: May have microtubule-stabilizing activity.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:16837464}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16837464}. Note=According to PubMed:16837464, it colocalizes with microtubules.
Interaction partners:
Sequence:
MAWPCISRLCCLARRWNQLDRSDVAVPLTLHGYSDPGSEESGADCSVSRGNPSVAGARESSRAVPLTQYQRDFGVRTARAGSRDAAQERPSGPGGRRGQSSAPPTRTVYVLPVGDADAAVVATTSYRQEFQAWTGVKPSRSTKARTARVVTTHSSGWDPSPGASFQVPEVRKFTPNPSAIFQTSAPQTLNV
Protein: C2 domain-containing protein (Q9BHL0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKPRRAPVIVKAFDENFQRPTEERDPYDDVQVEKVLKDLSFIRIKLDQIVLPDINPFIQKLHNYREFFGFQLEYTFPCLDAVSKSLKTTIRIPEKEVDIMKIVFNHRRIVLLNMHNDQIEHWQKSQLTIHLLVNMIVNGRQTTRPLAKCHVKLAELVRPPYLISRDFDFVGDDFEGTAELRIDLGSRVQSLTEKLTNLRNERSFDDNTFIVSDRQVGRRTRSRSSSRCRAHSSQSLGSATKDSARASASSSAAPSEIHKRSQSVTSIPAASTSTTTPTPILRPSTLQIPAQSYVAPPRPRIGSSASSMGSDSVFVRDPPTAQGAPPRVFEFPDSTESQFRERTHRTVTESYGASTVADTVEEVSRHGGKYYLEVTVHQATGLPPIEDESGCLASPSTLVSILGRDGDLRSPVFRNSRNPNWNFMARFALSSERRNLVVKVIHRGALLDLPLGFVSIPLPTPNFSRSVYEMTDITKMAAKYTHQVPMLTISVEKVRNIDDDDDDEENNHHYEQFRKRAHSSRSTQSSPPPPSAQYLLRIESPPILESSEVIKERMQRCMADLENMMRGINK