wanglab/gogpt-training-data huggingface dataset:
Protein: LMBR1 domain-containing protein 2 homolog B (Q54TM2)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Ankyrin repeat-containing protein
- Calponin-homology
- Phospholipase D B
- Uncharacterized protein
- Paxillin-B
- LIM domain-containing protein C
- SAP DNA-binding domain-containing protein
- Calcium-regulated actin-bundling protein
- LIM domain-containing protein D
Sequence:
MSSNTTTPTPTSTPTPTSSPSIGPVPIPYESASFGNLLFFAISLVLCGVVVLIGMKQYISLKRTPIYATFFSFLGWFMCFSIAYLVPLDIIVTDHLQCVIENNETLTGECEIPVTYLPYGMITQQWRFLYFGSLILCWVIFPVLQSFSTAGDFRFWERVKRATKENVILYTFMFIAGLIGIIVILSVKEMDPSSFLSFVMLLANVYGVILITITMGYGLIDVPRNLLRKGSHYAILRNYRVEAVVLKTELEDVKRQLIDHLKLIKTISDRAGQYDPFRIYLDVIISKCPTEYDVLIQEYHAEPLPAGMEAEILSYKYLVGIHSTLLDLVDRNHSAEVLYERLLGKAFAIEDIIETRERNKQTAGNNQIAGEERSIQWSFKSTKSNGKFEYLWHMYIHPWYFIIAGLVCVCLSGIILWSEIVLALVSNPDYSPFYRAIVRMEPGIGLQIFCFIPMIYMCVCSYSTLFKLRISNYYRLVPQQSNTFSIMFSANYLCRLAAPLAYNFIQICHVNQDNSIVSPFSKIMGDMNAFGDNALGKRFTLFFPIFMIVVCVISFFNLHKRLAGSCCIRSLRIVTDTSEGAVDHGLKILKQEREERSLTGGVAPVKTRMSIVKEMFTKKKGAGILVTDNSQLDGASGAHREPSIDSSNRYKPTPTKTSINIPKLSRTYTSAAGNVYSSTQDGDENSNSGIKPINSFFSSILGEKGNASNNNNNNNNNNNNNNSNNKNSNNNNNSILTSNYESYSTPRTKDKQGLLSSALDKMDFSFQDDDDHTFDDIEMGAYGTGRKNKK
Protein: GTPase KRas isoform 1 (EC 3.6.5.2) (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) (A0A2R8Q8S1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
- non-specific serine/threonine protein kinase
- Neurofibromin 1a.
- Bcl-2-like protein 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Cellular tumor antigen p53
- Epidermal growth factor receptor precursor.
- Mitogen-activated protein kinase kinase 1
- Dual specificity mitogen-activated protein kinase kinase 2
- Phosphatase and tensin homolog B
- non-specific serine/threonine protein kinase
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLQSHNVDSKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIREYRLRKLSKEEKTTQCIKLKKCVLM
Protein: Type-4 uracil-DNA glycosylase (EC 3.2.2.27) (TMUDG) (Q9WYY1)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA.
Interaction partners:
- Uncharacterized protein TM_0508
- Iron-dependent transcriptional repressor, putative
- UDP-glucose 4-epimerase, putative
- Guanylate kinase
- Peptide deformylase
Sequence:
MYTREELMEIVSERVKKCTACPLHLNRTNVVVGEGNLDTRIVFVGEGPGEEEDKTGRPFVGRAGMLLTELLRESGIRREDVYICNVVKCRPPNNRTPTPEEQAACGHFLLAQIEIINPDVIVALGATALSFFVDGKKVSITKVRGNPIDWLGGKKVIPTFHPSYLLRNRSNELRRIVLEDIEKAKSFIKKEG
Protein: Antitoxin protein TsiV3 (Q9KN41)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: Immunity protein that plays a role in preventing early activation of toxin VgrG3.
Interaction partners:
- Type VI secretion system spike protein VgrG3
- Transposase
Sequence:
MNNLLSAYVTMLLILLSISGGAIASENCNDTSGVHQKILVCIQNEIAKSETQIRNNISSKSIDYGFPDDFYSKQRLAIHEKCMLYINVGGQRGELLMNQCELSMLQGLDIYIQQYIEDVDNS
Protein: Prolyl endopeptidase (EC 3.4.21.-) (Q382P7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Serine peptidase, putative serine peptidase, Clan SC, Family S9D
Sequence:
MQTERGPIAAHRPHEVVFGKVEGEDRGANPMDPPRRKVDPLFWLRDDNRADPEVLAHLHLEKDYYEKRAVDIKDLAETIYQEHISHIEETDMSAPYVYDRFLYYTRDVKGLSYKLHCRVPAGKTPGEGEDEEIVLDENKLAEGKSFCVVGCVAPAPPEHALVAYSVDYCGDEVYSIRFVRDVVADKVEGTNGSVVWGPNAECFFYITKDASKRDNKVWRHIIGQPQSEDVCLYTDDDPLFSVGVGKSGDGKTLIICSMSSETSESLLLDLRKGVKHNTLEMVRPREKGVRYTVEMHGTDTLIVLTNKDKCVNGKVVLTKRSAPTDWGTVLIPHDDKVTIDDVAVFAKFAVLSGRRDGLTRVWTVRLGPDSLFSSATLKELHFDEPVFTAHVVCSQMKTYDASLLRLRYSSMTTPTVWYDEDVLSGERKVVKARKVGGGFQSKNYVCRRELATAPDGTKVPISLVYDTSIDLKKPNPTMLYGYGSYGICIEPEFNSRFLPYVDRGMIYAIAHVRGGGEMGRTWYEVGGKYLTKRNTFMDFIACAEHLISSGLTTPAQLSCEGRSAGGLLVGAVLNMRPDLFHVALAGVPFVDVMTTMCDPSIPLTTGEWEEWGNPNEYKFFDYMNSYSPIDNVRAQDYPHLMIQAGLHDPRVAYWEPAKWASKLRELKTDSNEVLLKMDLESGHFSASDRYKYLRENAIQQAFVLKHLNVRQLLRK
Protein: AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin) (P61967)
Organism: Mus musculus (Mouse)
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular location: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Interaction partners:
- AP-1 complex subunit mu-1
- AP-1 complex subunit gamma-1
- AP-1 complex subunit beta-1
- AP-1 complex subunit gamma-like 2
- AP-1 complex subunit mu-2
- AP-2 complex subunit beta
- AP-1 complex subunit sigma-2
- AP-2 complex subunit alpha-1
- AP-2 complex subunit mu
- AP-2 complex subunit alpha-2
Sequence:
MMRFMLLFSRQGKLRLQKWYLATSDKERKKMVRELMQVVLARKPKMCSFLEWRDLKVVYKRYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLMGGDVQDTSKKSVLKAIEQADLLQEEDESPRSVLEEMGLA
Protein: Zgc:77060 (Q6GPG2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSFTDEAVSILTSSSLLARSLLGRTSALKRKDVSPSSISSARRKREFIPHEKKDDGYWDKRKKNNEAAKRSREKRRVNDMVLENRVLTLLEENARLRAELLALKFRFGLIKDPSNASILPLTTGSCVPQPSAQHYYLPRGDGAHHTGPMPSNQSPTQSAPPSSRSIRDTSSMSEDSGFSTPGGSSVGSPVFFEDRLSDHGKLSPHRADELCYESHHSPSDLLAVGNHNMPSTRLESMDGMKSLPHKLRFKSPGGGDCENLGERQSAAIPMANARVHSYTHEGAGYWTPHDGEDARKVIQQQHVNYSHNVNANESQYQAENSMLKSQLSSLSEEVAQLKKLFSEQLLTKTN
Protein: Hexosyltransferase (EC 2.4.1.-) (Q3UU43)
Organism: Mus musculus (Mouse)
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000256|ARBA:ARBA00004447, ECO:0000256|RuleBase:RU364016}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004447, ECO:0000256|RuleBase:RU364016}.
Interaction partners:
- Chondroitin sulfate N-acetylgalactosaminyltransferase 2
- Chondroitin sulfate N-acetylgalactosaminyltransferase 1
- Chondroitin sulfate synthase 1
- Chondroitin sulfate synthase 2
- Chondroitin sulfate synthase 3
Sequence:
MRLSSLLALLRPVLPLILGLSLGCSLSLLRVSWIQGEGEDPCVEAVGKPGGPQNPDSKNGLDQGDEDFRPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARAPAGMQVVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDLYLGHAEEFIGTGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDTLGIGCVSQHQGQQYRSFELAKNRDPEKEESPAFLSAFAVHPVPEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTVLTPEGEAGLSWPVGLPAPFTPHSRFEVLGWDYFTEQHTFACADGAPKCPLQGASRADVGDAVDTALEQLNRRYQPRLRFRKQRLLNGYRRFDPARGMEYTLDLLLEAVTQRGHRRSLARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLLVAEAPAALAFLEAFAASVLEPREHALLTLLLVYGPREGRGGPDPFLGVKAAAAELERRYPGARLAWLAVRAEAPSQVRLMDVISKKHPVDTLFFLTTVWTRPGSEVLNRCRMNAISGWQAFFPVHFQEFNPALSPQRSPPGVPGADPPSPGVDPSRGAPVGGRFDRQASAEGCFYNADYLAARARLAGELAGQEEEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLGARTQLAMALFEQEQANST
Protein: AB hydrolase-1 domain-containing protein (Q581X1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Acyl carrier protein
Sequence:
MQGATVSAPNFRPPTELLDEVPQPEGSSWWLQTSAARLQSFELRMLHAIKYRQGFVAGLNTITTLGLQQSAANSSKEIMVLIHGFAGGLACWAQNWEFLSEHYILCALDLPGFGRSMRPNVTARTPREVLDFFCQCLDDWFGEMRFKIPVILVGHSFGAYIAAHYSMRRGPSCVRLLVFVDPWGVNRRDQSGSKRVPFTWRLALSIANRMNPLTLVRAAGPLGPLFFRLIRPDFANRWRGYLPDPVTFYEYTYHCNAQLPPLGEELFKICYHHDITAKEPLEDELPSSLSKDIPLVLLYGSETWMDAERGTTMADKMEGMGFKVEVDTVMSAGHQVFTDNPSEFNNKLLLALAELLA
Protein: Transmembrane protein (Q9I082)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
Sequence:
MIAFALACHCLSISTMPFRKHLLLPLLGLALLLGGCGPSVSYSYIPPTSDAGLHCVSQCNAEKRQCKTLSKLQQRQDEALYQAQSTAYNYCMQNSDKKKRKSCPYPQRNFDFGDDCQEEYRSCYQSCGGTIRRIVHQD
Protein: T. brucei spp.-specific protein (Q583H0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- T. brucei spp.-specific protein
- Uncharacterized protein
- Hexosyltransferase
Sequence:
MVRNMGGNAPNAARKPTPAVPQYVVFRYPTQNIPSFEPLRPMHPKLHDIMTQRRGITSPHVPAPVTGFVSRNDYGGGTLQFRTTTAPPHAPVTRMEGINEKYWDKCKRSYGTKLNFAPRVAKKNLHTQHPSQGMVKWVAGTPVMGESPANYPSAHFHQSYVKRNFPQTFNSTTVMGMCPQKRMRADGASEPQKNYPPQYKYDEWSERERGEGSNGNSDNNNNNINIINNNNNNSNNSDDDPLLLLHGINELGQVQKFRCRKSYLLELAEAVRIADRLRCEIPNAINEPYREQQPDTSSRSESADNNDEVQDEEMHSEHLNAQSREQMDGEETSSISSTSSSSTSNSISDSPVKDGMHFRDMFRKRAHTLGYEISDNVAVEVAPPYGMEAAGEKRNEIQSEG
Protein: Cyclin-dependent kinase 6 (A0A8I6A5X3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAELFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLVSSWNVVGLCHWDSMTSSVSTLNHVTWE
Protein: Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) (Q969T4)
Organism: Homo sapiens (Human)
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
Subcellular location: Nucleus {ECO:0000269|PubMed:15545318}. Cytoplasm {ECO:0000269|PubMed:15545318}. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 E1
- Ubiquitin-conjugating enzyme E2 E2
- Importin-11
- Ubiquitin-like modifier-activating enzyme 1
- Glutaryl-CoA dehydrogenase, mitochondrial
- E3 ubiquitin-protein ligase NEDD4-like
- E3 ubiquitin-protein ligase RNF5
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- Polyubiquitin-C
Sequence:
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQWTKRYAT
Protein: Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2) (Q96L33)
Organism: Homo sapiens (Human)
Function: Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9Z1Y0}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z1Y0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z1Y0}. Endosome membrane {ECO:0000250|UniProtKB:Q9Z1Y0}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z1Y0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z1Y0}. Note=Treatment with TNF activates endosomal but not plasma membrane RHOV. {ECO:0000250|UniProtKB:Q9Z1Y0}.
Interaction partners:
- Serine/threonine-protein kinase PAK 6
- Serine/threonine-protein kinase PAK 4
- Rho guanine nucleotide exchange factor 7
- SH2/SH3 adapter protein NCK1
- Cytoplasmic protein NCK2
- Serine/threonine-protein kinase PAK 1
- Actin nucleation-promoting factor WASL
- Serine/threonine-protein kinase PAK 2
- Partitioning defective 6 homolog beta
Sequence:
MPPRELSEAEPPPLRAPTPPPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCNGYPARYRPTALDTFSVQVLVDGAPVRIELWDTAGQEDFDRLRSLCYPDTDVFLACFSVVQPSSFQNITEKWLPEIRTHNPQAPVLLVGTQADLRDDVNVLIQLDQGGREGPVPQPQAQGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKARLEKKLNAKGVRTLSRCRWKKFFCFV
Protein: Uncharacterized protein (Q57UL3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Methyltransferase type 11 domain-containing protein
- Uncharacterized protein
Sequence:
MAAIFPKEWNTEALVWFATYHLDFTKNDIGLLKETCEALVVDTNSVCSLVWERPLTPFSSAAGQSVALGAASFPIEHFRSSFSAGSKKIFTETPVVIEPSGSGPPSNSHRMYLLSLLRRLENGRSVLRSINEKYGFAFSVSTLGRRTFDGVVRGKVSGHGGSPCPQPGLGGTEERHTLVSNGRQNCTVNQDERSTFYVNMSFAMFLRTFDVLISWVSNAISVIDGEGTVPSAGGYVIHEDVQCGTDEGDSNGSCDQLQDDFKWTAEAHRLEPAQPLLERQERVSPEPFSATYNEPRPAMRRARTVRVTVYEIHDVRSVFLRHQSQLNLFYDHEYTFHDQRLNRRLLLPAYYKALREFIDELNSEVEQLERLGVSLACGRSDQVTIVFRPSICEFRYMRDSLILYWSECVTEDDITAFARYSAEYNECVSEAAAVFEMLKELRRPQTENLGTSVGPVFTLEERGALGAGFESYWRLRERVFQLRNSLKDDIENKNRTHRYFIPELLSKPASRQERGIGSASSIVQHVWSKVVFWSGLLSCSAELPGNFPTSGGTSEKCVLSTKSPQYEPKMELLQHTRRMVEAVEAQGAILERDYRGVFFRDTGALWKQRATDLVHRLEGVSTVFSKPN
Protein: Small ribosomal subunit protein eS12 (40S ribosomal protein S12) (P63323)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P25398}.
Interaction partners:
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein eS10
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein uS2
Sequence:
MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFKCKK
Protein: SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (P63283)
Organism: Gallus gallus (Chicken)
Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P63280}. Cytoplasm {ECO:0000250|UniProtKB:P63280}.
Interaction partners:
- Small ubiquitin-related modifier 1
- SUMO-activating enzyme subunit 2
- RanGAP1_C domain-containing protein.
- SUMO1 activating enzyme subunit 1.
- Small ubiquitin-related modifier 2
- Small ubiquitin-related modifier 3
- TAR DNA-binding protein 43
- Uncharacterized protein.
- Uncharacterized protein.
- Protein inhibitor of activated STAT 3.
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
Protein: Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) (P0A847)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Interaction partners:
- S-adenosylmethionine:tRNA ribosyltransferase-isomerase
- Sec translocon accessory complex subunit YajC
- NADPH-dependent 7-cyano-7-deazaguanine reductase
- Thymidylate synthase
- Protein translocase subunit SecD
- 6-carboxy-5,6,7,8-tetrahydropterin synthase
- 7-cyano-7-deazaguanine synthase
- 7-carboxy-7-deazaguanine synthase
- Epoxyqueuosine reductase
- tRNA pseudouridine synthase B
Sequence:
MKFELDTTDGRARRGRLVFDRGVVETPCFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRERFDSLGNKNALFGIIQGSVYEDLRDISVKGLVDIGFDGYAVGGLAVGEPKADMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKYKSDTGPLDPECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTDFYQRQGREVPPLNVD
Protein: Bile salt hydrolase (I3QNS9)
Organism: Bifidobacterium animalis subsp. lactis (Bifidobacterium lactis)
Interaction partners:
Sequence:
DDGQNNMYFGRNLDWSEDYGEKIVFAPHDYHYAPAFNAEDKNHPVIGIGIIVEDTPLYFDCMNDAGLAVAGLNFAKYCKYATEAVNFTTNVAAYEFPLWVTRNFTSVDDVQEALKNVTIVGKPINDRFPVATLHWIIADNTRSIVVECTEDGMHVYDDDV
Protein: Mitochondrial import inner membrane translocase subunit Tim17-B (O60830)
Organism: Homo sapiens (Human)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim23
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import inner membrane translocase subunit Tim21
- Stress-70 protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit Tim10
- Mitochondrial import receptor subunit TOM20 homolog
- Cytochrome c oxidase subunit 5B, mitochondrial
Sequence:
MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAPVGIRHRLRGSANAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSGPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFRNAPPFLEDPSQLPPKDGTPAPGYPSYQQYH
Protein: Forkhead box K, isoform P (M9PC64)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MAATTTTTTTTLATTTGNSSSTNNSSSNNNNSIASSHNNNNNIVTVHTVLNNPPTNTAGGGVADAATVAIAKDMLQLHHGAAAAATAALNNYNNSSNNNNNSADQLTGNSNNSANHPPATSSTTNSSSSSTTSANTNNPSANAASTLTSSSPPYGELRFNQEVLPITDAVTVIGRNSSTSLVHFNVAENNLVSRKHFQVLYDVELRAFFVQCLSKNGIFVDDFLQRRNVDPLRLPQRCYFRFPSTEIRIEFESYVPATSSDAIDGHSPSLVVGGGGGVAGGGAHVIITPLPRDELHQQQLHHHQQQPHLQQQQHPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVAPPAGAAAHLIAGDGPGIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSGSPYYVTNQSSGVATPQTHVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTLHQQQAVAQQQHSEIIYEELPTDYSGHIEASEEECVTTATDATVAKRPKYVSEVL
Protein: T-box protein 38 (Q9XVD5)
Organism: Caenorhabditis elegans
Function: Transcription factor (By similarity). Required for mesodermal induction, acting redundantly with transcription factor tbx-37. Together with tbx-37, acts by inducing cell fates in the AB lineage, thereby playing a role in development of the anterior pharynx.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201, ECO:0000269|PubMed:15056620}.
Interaction partners:
- Protein pop-1
- Helix-loop-helix protein 14
Sequence:
MYSCTSPSGIKVSLSTPEIWEEFYPKTEMIVTRNRGRVIFPHLDYIIKGLDPGSLYSIYIHLERVDGIKYKFDAGEWKEFAKGDPILPIQYKEHPRGKRTGAEWMSEPVSFAHIKITNNPEIKDQKVILVQSMHKHIPVVTVKQVRHYKTGYQEDFSGEQFRLEATEFMVVTAYQNEILKNLKVHHNKFASGFRSNGKRRLSSDSENSENSPPKRSKLVTPPTISPQIDLPQQTPYYFNQNFVAPQNYQPQFASAQNYNFEVQNNAQLAWNMYYQKQYEFWWQQQQMMMPGQPQELKNEFQSL
Protein: Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin) (Q9Y2T1)
Organism: Homo sapiens (Human)
Function: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21383061}.
Interaction partners:
- Axin-1
- Adenomatous polyposis coli protein
- Glycogen synthase kinase-3 beta
- Catenin beta-1
- Casein kinase I isoform alpha
- Segment polarity protein dishevelled homolog DVL-1
- Transcription factor 7
- Adenomatous polyposis coli protein 2
- Segment polarity protein dishevelled homolog DVL-2
- Poly [ADP-ribose] polymerase tankyrase-2
Sequence:
MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVERID
Protein: Long chronological lifespan protein 2 (Q08045)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway that acts upstream of HRD3 and USA1.
Interaction partners:
- DnaJ-like chaperone JEM1
- Uncharacterized protein YIL152W
Sequence:
MSQSRWSIVLIFALFIFGSTGVNAFFNFGHHQQQQQQQQQSYEDQVLNNPCDGYLCPDTLTCVAQQKDCPCPFPKSQLKCVLPDNKFVCISKPATHNEKFRAIYDDPVKGPKAKNKGFRDCGWVSDAYKNH
Protein: procollagen-proline 4-dioxygenase (EC 1.14.11.2) (F4J0A6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648}.
Interaction partners:
Sequence:
MDSRIFLAFSLCFLFTLPLISSAPNRFLTRSSNTRDGSVIKMKTSASSFGFDPTRVTQLSWTPRVFLYEGFLSDEECDHFIKLAKGKLEKSMVADNDSGESVESEDSVSVVRQSSSFIANMDSLEIDDIVSNVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFHDQANLELGGHRIATVLMYLSNVEKGGETVFPMWKGKATQLKDDSWTECAKQGYAVKPRKGDALLFFNLHPNATTDSNSLHGSCPVVEGEKWSATRWIHVKSFERAFNKQSGCMDENVSCEKWAKAGECQKNPTYMVGSDKDHGYCRKSCKACSS
Protein: ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) (Q9H8K7)
Organism: Homo sapiens (Human)
Function: ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25063848}. Mitochondrion {ECO:0000269|PubMed:25063848}.
Interaction partners:
Sequence:
METRTEDGGLTRRPTLASSWDVAGGALTHSLLLTRAGLGPGDFDWEELLAPPAPGQDLVILKRNHNNKDENPCFLYLRCGPDGGEEIASIGILSSARNMEVYLGEEYCGTSRGKNVCTVLDDSEHEKIILYKKNLKLESSTHACKIKLLSFGERQCVFISKVVVHMRSVFANSSTSSPALGSRIDLDKVQTIMESMGSKLSPGAQQLMDMVRCQQRNCIPIGEQLQSVLGNSGYKHMIGLQSSSTLGTLNKSSSTPFPFRTGLTSGNVTENLQTYIDKSTQLPGGENSTKLDECKVMPQNHSFLENDLKNAMASFLPKKVSDNSNIPNSELLPFLQNLCSQVNHLHVGNKTECQENITKHGERILGVGMEEQSICSYLEKILSKNMELMEKKLMDYIDQRIHELQEHIDDKIALLLDLLQNPNSPPTGIPLRHYDSGERLSNGER