wanglab/gogpt-training-data huggingface dataset:
Protein: Homeobox protein unc-30 (Uncoordinated protein 30) (P52906)
Organism: Caenorhabditis elegans
Function: Transcriptional regulator within D-type neurons that controls terminal differentiation. Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid-secreting) D-type motor neurons, which control locomotion. Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1. Also required for expression of flp-13 in DD motor neurons. Plays a role in respecification of DD motor neurons through regulation of genes involved in the modulation of cellular cAMP including pde-4 which hydrolyzes cAMP and acy-1 which catalyzes cAMP formation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:7997265}.
Interaction partners:
- Nuclear hormone receptor unc-55
- Transcription factor unc-3
- Vesicular GABA transporter
- Immunoglobulin domain-containing protein oig-1
- Glutamate decarboxylase 1
- LIM/homeobox protein ceh-14
Sequence:
MDDNTATLTAIHQQQQSHNRFSNPLVCVGQLDHHSLLPEHSISSSLAPLTHNPYAFNYSIPLPPTDITTKLPKLELLSLDVKQEQDDNHLDTSSPTDSTGNGSTNGGKIQKPRRQRTHFTSHQLTELENWFSRNRYPDMACREEIAVWISLTEPRVRVWFKNRRAKWRKRERNYVIDNGQGTTKVTAQSLDPLGSLQNTFPQTLLQSSSSQLDDSAVTSSSFYGYGGAWQQNPYYSRNNQTTFNWQIKPQDQFQFQTIPMSPTTATSRFSTAANLAPLPTAQAAFSTSATSSNDKLKLMDGLSNSLSSSLGQPYQPCQYSGPL
Protein: Heterogeneous nuclear ribonucleoprotein A0 (B5X9X4)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MDNSSQLCKLFVGGLNVDTDDDGLRKHFEQYGQLTDCVVVVNKQLQRSRCFGFVTYSSAEEADAAMAARPHVVDGTNVELKRAVAREDAGKPEALAKVKKIFIGGLKDDIEDEHLNEYFSQFGEIEKAEVIAEKETGKKRGFGFVHFTDNDSADKAVVLKFHNIKPCSKFSPRAFGKMRTL
Protein: Glypican-2 (Cerebroglycan) (HSPG M13) [Cleaved into: Secreted glypican-2] (P51653)
Organism: Rattus norvegicus (Rat)
Function: Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; SUBCELLULAR LOCATION: [Secreted glypican-2]: Secreted, extracellular space {ECO:0000250}.
Interaction partners:
- Chondroitin sulfate proteoglycan 5
- Syndecan-1
- Syndecan-3
- Syndecan-2
Sequence:
MSAVRPLLLLLLPLCPGPGPGHGSEAKVVRSCAETRQVLGARGYSLNLIPPSLISGEHLQICPQEYTCCSSETEQKLIRDAEVTFRGLVEDSGSFLIHTLAARHRKFNEFFREMLSISQHSLAQLFSHSYGRLYSQHAVIFNSLFSGLRDYYEKSGEGLDDTLADFWAQLLERAFPLLHPQYSFPPDFLLCLTRLTSTADGSLQPFGDSPRRLRLQITRALVAARALVQGLETGRNVVSEALKVPMLEGCRQALMRLIGCPLCRGVPSLMPCRGFCLNVAHGCLSSRGLEPEWGGYLDGLLLLAEKLQGPFSFELAAESIGVKISEGLMHLQENSVKVSAKVFQECGTPHPVQSRNRRAPAPREETSRSWRSSAEEERPTTAAGTNLHRLVWELRERLSRVRGFWAGLPVTVCGDSRMAADLSQEAAPCWTGVGRGRYMSPVVVGSLNEQLHNPELDTSSPDVPTRRRRLHLRAATARMKAAALGQDLDMHDADEDASGSGGGQQYADDWKAGAAPVVPPARPPRPPRPPRRDGLGVRGGSGSARYNQGRSRNLGSSVGLHAPRVFILLPSALTLLGLR
Protein: Soluble and membrane-bound lytic transglycosylase (Q9HVX3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Trans-aconitate 2-methyltransferase
- EamA domain-containing protein
- Inhibitor of vertebrate lysozyme
Sequence:
MRRTALALPLFLLVSACSSEPTPPPKPAAKPQARTVISPRPVRQSVQPILPLRGDYANNPAAQHFIDRMVSQHGFNRQQLHDLFAQTQRLDWVIRLMDRQAPTYTPPSGPNGAWLRYRKKFVTPGNVQNGVLFWDQYETDLQRASRVYGVPPEIIVGIIGVETRWGRVMGKTRIIDALSTLSFSYPRRAEFFSGELEQFLLQARKEGTDPLALRGSYAGAMGYGQFMPSSFTKYAVDFDGDGHIDLWNPRDAIGSVANYFKQHGWVSGDRVAVPASGRAPSLEDGFKTLYPLDVLASAGLRPQGPLGGHRQASLLRLDMGRNYQYWYGLPNFYVITRYNHSTHYAMAVWELGKEVDRVRHRSVVRQD
Protein: Selenoprotein N (SelN) (Q9NZV5)
Organism: Homo sapiens (Human)
Function: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity. Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation.
Subcellular location: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12700173}.
Interaction partners:
- Selenoprotein K
- Protein adenylyltransferase SelO, mitochondrial
- Thioredoxin reductase-like selenoprotein T
- Selenoprotein S
- Selenoprotein F
- Selenocysteine insertion sequence-binding protein 2
- Selenoprotein M
- Ryanodine receptor 1
- Selenide, water dikinase 2
- Methionine-R-sulfoxide reductase B1
Sequence:
MGRARPGQRGPPSPGPAAQPPAPPRRRARSLALLGALLAAAAAAAVRVCARHAEAQAAARQELALKTLGTDGLFLFSSLDTDGDMYISPEEFKPIAEKLTGSCSVTQTGVQWCSHSSLQPQLPWLNUSSCLSLLRSTPAASCEEEELPPDPSEETLTIEARFQPLLPETMTKSKDGFLGVSRLALSGLRNWTAAASPSAVFATRHFQPFLPPPGQELGEPWWIIPSELSMFTGYLSNNRFYPPPPKGKEVIIHRLLSMFHPRPFVKTRFAPQGAVACLTAISDFYYTVMFRIHAEFQLSEPPDFPFWFSPAQFTGHIILSKDATHVRDFRLFVPNHRSLNVDMEWLYGASESSNMEVDIGYIPQMELEATGPSVPSVILDEDGSMIDSHLPSGEPLQFVFEEIKWQQELSWEEAARRLEVAMYPFKKVSYLPFTEAFDRAKAENKLVHSILLWGALDDQSCUGSGRTLRETVLESSPILTLLNESFISTWSLVKELEELQNNQENSSHQKLAGLHLEKYSFPVEMMICLPNGTVVHHINANYFLDITSVKPEEIESNLFSFSSTFEDPSTATYMQFLKEGLRRGLPLLQP
Protein: Nuclear transcription factor, putative (EC 6.3.2.-) (Q57VH9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVEITELAKDISERLRNGSYECVICSNAVYLRDKLWSCTVCYGVVHMPCVRSWVKVQVEEREKRDATAGGSSASSISLNEFRCPICQALTPVSAVAEFSCFCGKVCNPTPDPLLVPGSCGDTCGRRRKDELCPHACTLMCHPGPCTPCQLTRTQSCFCGKTSKTVGCSSGIHGFECEGICGKLRECGKHNCGVPCHEGPCPVCTILSTDSCYCGATKRTQRCGESGPFPCGTPCSKILDCGNHRCLSKCHKDACEPCFRTPERMVFCPCGKVRLQQLLNSPRKSCLDPIPSCGLVCEGFLPCGHTCSDVCHESPTCPPCTKLVSMKCGCGSQNYQIYCFFTYLPQGEWKAAAERSGLSKDKIISHFPPVCKKPCRKHLSCGKHTCKENCCTNEDHTCYKICTKRLSCGTHSCGQLCHKGLCLPCSVASYDRLYCRCRRTWVEPPVPCGTKPPNCSHECIVPRPCGHPANHPCHIENECPVCVVPVEKKCGSHATVIPYYLPCYRESVSCGKKCGKLMSCCGKPCGKICHIGKCEHKCQTPFPALE
Protein: Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) (Q15052)
Organism: Homo sapiens (Human)
Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Subcellular location: Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q8K4I3}.
Interaction partners:
- ARF GTPase-activating protein GIT1
- Beta-parvin
- ARF GTPase-activating protein GIT2
- Serine/threonine-protein kinase PAK 1
- Serine/threonine-protein kinase PAK 3
- Rho guanine nucleotide exchange factor 7
- Serine/threonine-protein kinase PAK 2
- Cell division control protein 42 homolog
- Paxillin
- Ras-related C3 botulinum toxin substrate 2
Sequence:
MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
Protein: Pyridoxal 5'-phosphate synthase subunit PDX1.3 (AtPDX1.3) (AtPDX1;1) (PLP synthase subunit PDX1.3) (EC 4.3.3.6) (Q8L940)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.
Subcellular location: Cytoplasm. Cell membrane. Membrane.
Interaction partners:
- Probable pyridoxal 5'-phosphate synthase subunit PDX2
- Pyridoxal 5'-phosphate synthase-like subunit PDX1.2
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
- Thiamine phosphate phosphatase-like protein
- Pyridoxal kinase
- Inorganic pyrophosphatase 2
- Pyridoxal 5'-phosphate synthase subunit PDX1.1
- Inorganic pyrophosphatase 1
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 2
- transaldolase
Sequence:
MEGTGVVAVYGNGAITEAKKSPFSVKVGLAQMLRGGVIMDVVNAEQARIAEEAGACAVMALERVPADIRAQGGVARMSDPQMIKEIKQAVTIPVMAKARIGHFVEAQILEAIGIDYIDESEVLTLADEDHHINKHNFRIPFVCGCRNLGEALRRIREGAAMIRTKGEAGTGNIIEAVRHVRSVNGDIRVLRNMDDDEVFTFAKKLAAPYDLVMQTKQLGRLPVVQFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDPARRARAIVQAVTHYSDPEMLVEVSCGLGEAMVGINLNDEKVERFANRSE
Protein: Cdc42-interacting protein 4, isoform E (M9NF10)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLALLASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIFNIFGSNKQRQIIEACITMKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSSSSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEITLYA
Protein: Homeobox-leucine zipper protein ATHB-7 (HD-ZIP protein ATHB-7) (Homeodomain transcription factor ATHB-7) (P46897)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription activator that may act as growth regulators in response to water deficit.
Subcellular location: Nucleus.
Interaction partners:
- NAC domain-containing protein 72
- ABSCISIC ACID-INSENSITIVE 5-like protein 6
Sequence:
MTEGGEYSPAMMSAEPFLTMKKMKKSNHNKNNQRRFSDEQIKSLEMMFESETRLEPRKKVQLARELGLQPRQVAIWFQNKRARWKSKQLETEYNILRQNYDNLASQFESLKKEKQALVSELQRLKEATQKKTQEEERQCSGDQAVVALSSTHHESENEENRRRKPEEVRPEMEMKDDKGHHGVMCDHHDYEDDDNGYSNNIKREYFGGFEEEPDHLMNIVEPADSCLTSSDDWRGFKSDTTTLLDQSSNNYPWRDFWS
Protein: Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNase I homolog protein DHP2) (Deoxyribonuclease I-like 3) (DNase I-like 3) (Liver and spleen DNase) (LS-DNase) (LSD) (Q13609)
Organism: Homo sapiens (Human)
Function: Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity. Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:11141064, ECO:0000269|PubMed:23229555}. Endoplasmic reticulum {ECO:0000269|PubMed:23229555}. Secreted {ECO:0000269|PubMed:9714828}. Note=Translocates from the endoplasmic reticulum to the nucleus during apoptosis (PubMed:23229555). Contradictory reports exist about the subcellular localization under normal physiological conditions. Under conditions of cell death, may diffuse and/or be actively transported to the nucleus. {ECO:0000269|PubMed:23229555, ECO:0000305}.
Interaction partners:
Sequence:
MSRELAPLLLLLLSIHSALAMRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVMEIKDSNNRICPILMEKLNRNSRRGITYNYVISSRLGRNTYKEQYAFLYKEKLVSVKRSYHYHDYQDGDADVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELVEVYTDVKHRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGDQEDTTVKKSTNCAYDRIVLRGQEIVSSVVPKSNSVFDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKSVTLRKKTKSKRS
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q8IFM1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Protein phosphatase PPM5, putative
Sequence:
MKKKTREEIIIFLKWVSCKKYIFSVFVFLCCFLMSFNIFEPRIEIIELNWHVRYYRHLTEVWDNNNNNDEGEQNLKDKYDTYDEKEKVKKKYVEDEFNTKEKVKKKHRDDKYNKKEKSKKKHRDDKYNKKEKSKKKYVEDKFNKKNKHKENDVSLKKDQCKKSLSIREDCNNKNSKSYNEKEICDNENCVNLEDIKIYDNTTWKYKIKKLITCSYNSDKDAKVLYNWKLGKSILGKMINSTEDFSINGISYKDWTLNTIPDIGYSQNNRRSQEVFKTEVKSKDENTESVKLFIKKVPASIWVRQYIILNEHKGEYSLGEENFVMEAISLAFLNKYYPGIAPKFYGILYESPDKPNDNVCFSFGRGKCNNLKKFNDMLINQLQLNNKANVIMISELYGEDVFKYVKNKRKEGCFGNNLEEKKKILHESLKLITTLHETGLSHLDISPENILIGNNCELKLCDFANSAPIYTYNNRHLKGNKRLRYYESYQPCISKVPLLPPECWNIVRIHEKLKINDPYDYLKSITNQEERKSFYFNVSNADKFMLGIFFIWVWNNNYIWEKADSFNDRKFRNFVKCGMDLYNYELTYNWPDDLKDIINQLLPLENRAQLSLKELCKHPWWSN
Protein: ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Potassium channel, inwardly rectifying subfamily J member 12) (P52188)
Organism: Rattus norvegicus (Rat)
Function: Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:21209095}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:21209095}.
Interaction partners:
- Inward rectifier potassium channel 2
- Inward rectifier potassium channel 4
- Potassium voltage-gated channel subfamily KQT member 1
- Potassium voltage-gated channel subfamily KQT member 2
- Potassium voltage-gated channel subfamily KQT member 3
- Potassium voltage-gated channel subfamily Q member 5
- Potassium voltage-gated channel subfamily KQT member 4
- Guanine nucleotide-binding protein G
- ATP-sensitive inward rectifier potassium channel 14
- Disks large homolog 1
Sequence:
MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMGRPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEVATDRDGRSPQPEHDFDRLQASSGALERPYRRESEI
Protein: HTH-type transcriptional regulator NfxB (P32265)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Confers resistance to guinolones. May negatively regulate the expression of genes that are associated with cell permeability to drugs.
Interaction partners:
- Efflux pump membrane transporter
- Resistance-Nodulation-Cell Division
- Outer membrane protein OprJ
- DNA topoisomerase 4 subunit A
- DNA gyrase subunit A
- Transcriptional regulator MexT
- NalD
- Outer membrane protein OprM
- Multidrug resistance operon repressor
- Multidrug efflux outer membrane protein OprN
Sequence:
MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS
Protein: Rho family-interacting cell polarization regulator 1 (Q68FE6)
Organism: Mus musculus (Mouse)
Function: Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17251388}. Golgi apparatus {ECO:0000250|UniProtKB:Q6ZS17}. Note=Localizes to the podocyte major processes and cell body (PubMed:17251388). Colocalized with STK26 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with STK26 upon serum stimulation in a Rho- and PDCD10-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q6ZS17, ECO:0000269|PubMed:17251388}.
Interaction partners:
- Ubiquitin-like protein FUBI
Sequence:
MMSLSVRPQRRLLSARVSRSQSFAGVLGSHERGPRSFTVFSPPGPPRKPLVLSRVSRMFSVAHPAPKVPQPERLDLVYTALKRGLTAYLEVHQQEQEKLQRQIKESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKIDELYEAYCVQRRLRDGAYNMVRAYSTGSPGSREARDSLAEATRGHREYTESMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEETVFLPLLTEFLSIKVTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAASTVNKASTVTKRFSTYSQSPPDTPSLREQAFYNMLRRQEELENGTAWSLSSESSDDSSSPQLSGTARHSTPKPLVQQPEPLPVQVAFRRPESLTSGSMDEEPAMTPSLVNGHAPYSRTLSHISEASVDAALTEAVEAVDSQSPIPGPSPLVYPDSTHVERVSSVLPVLNNGHSATSPALSTTGPAPTFIDPAPTTQLDLVHKTTDSAPSELPSITHTTTSSAYSAVSLVNSVPSLTSTTIGSAHTTTPSPLTSTGSVPNATDSTQATPSPTHSTPSPTHTTIRLTHTTVSPTHSSPSPIHTTPSPTHTTVSPTCTTPSSGHSTTSPTQEAKMSTHTTGAVGPVQTTTSPISTTESPSPSTDVAIISSSSAESTGPGTEPLPCSHPASPPYTKADPTASCTSYQSLASSGSKPLTSPAPDSPEQIPKSPSSSPSSSAPEPQHSEHNLAAVAQAPVPEATGGAGDRRLEEALGTLMSALDDYRGQFPELQGLEQEVTRLESLLMQRQGLTRSRASSLSITVEHALESFSFLNDDEDEDNDGPGDRHTSSPEVVAEDRLDSSNGQSLSTGCSALDATLVQHLYHCSRLLLKLGTFGPLRCQEAWALERLLREARVFQEVCERSKLWGNSATSAQEVVQFSASRPGFLTFWDQCTEGLSPFICSVERVLLTFCSQYGARLSLRQPGLAEAVCVKFLEDALGQKLPRRPQPGPGEQFTIFQFWSYVEALDSPSMDAYVTETAEEVLLVQNLNSDDQAVVLKALRLAPEGRLRKDGLRALSSLLVHGNNKVMAAVSTQLRSLSLGPVFRERALLCFLDQLEDGDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEEGQSAHRQLEESLDALPCIFGPSSMASTAF
Protein: L-seryl-tRNA(Sec) kinase (EC 2.7.1.164) (O-phosphoseryl-tRNA(Sec) kinase) (Q8BP74)
Organism: Mus musculus (Mouse)
Function: Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. No activity with other tRNAs has been detected.
Interaction partners:
- O-phosphoseryl-tRNA
- Serine--tRNA ligase, cytoplasmic
- Serine--tRNA ligase, mitochondrial
- Selenide, water dikinase 2
- Selenocysteine-specific elongation factor
- tRNA selenocysteine 1-associated protein 1
- Selenocysteine insertion sequence-binding protein 2
- Selenide, water dikinase 1
- Selenocysteine lyase
- Protein KTI12 homolog
Sequence:
MKTAAARGATRRDGQPKLGLCVLCGLPAAGKSTFARALALRLRRERGWAVGVLSYDDVLPLALPDCDGTQPRPSQWKMFRQELLKHLECFLVAVISGAQMSAPPNRTEAVWEDFITCLKSQDLMIFPTALEAQPCHLLAKPAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLFLDCPLETCLKRNGERSQPLPDETIQLMGRKIEKPNPEKNAWEHNSLIIQSSACSLEASLEVTGLLLTALENPIKCVEDNTEQKETDRIICSTNILHKADETLRRTVSQTMREAKDEQIPLNNLKHLAEELNKLKADVLEDLRQGNRKYLCFQQTTDLSDIISSFCKERDTIVQKYFSKQH
Protein: Small ribosomal subunit protein uS15c (30S ribosomal protein S15, chloroplastic) (Q9LMQ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid {ECO:0000256|ARBA:ARBA00004474}.
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Small ribosomal subunit protein uS9m
- At1g64880
- Small ribosomal subunit protein mS29
- 50S ribosomal protein L33
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein bS16m/bS16c
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- Large ribosomal subunit protein mL46
Sequence:
MALHLARRHQRLPSNTSLIRFFSNSSSDSPPQFTNAPVEKPSQSPSSPSPSDSSPIFDIKNTLKLKLQNQQEQGRKPFDRSDAQSQNRGSTSFSQNLGKNLAKFQRRSTVPPPRDSGGVQPPSYISLAGLYKQSAATNSSDPRNSKAQGFNSNTVSETLKNLRTQINTSNNMGKRGGVLGSFKSTVGEALPKYLFETQMDESKGSEGETEEAMTEFLMFYNEEELGEKLRTLRPEGEKKEGWFSLEELNQRLVKLRQVEEKEAQYRTKNFAQLRNVISSFKNENSEASSQQNVAIMGHLGGIPEYKLLPPKEDLVDTYFHPDNMSSAEKMKIELSKVREEFKMSESDCGSARVQVAQLTTKIKHLSSSLHKKDKHSRKGLLGMVQKRKKLLKYLRRTDWDSYCLVLSKLSLRDNPDYKC
Protein: Cytochrome c oxidase subunit 6A2, mitochondrial (Cytochrome c oxidase polypeptide VIa-heart) (COXVIAH) (P10817)
Organism: Rattus norvegicus (Rat)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07471}; Single-pass membrane protein {ECO:0000250|UniProtKB:P07471}.
Interaction partners:
- Cytochrome b-c1 complex subunit 8
- Ubiquinol-cytochrome c reductase, complex III subunit X.
- Cytochrome c oxidase subunit 6B1
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 1
Sequence:
PLKVLSRSMASASKGDHGGAGANTWRLLTFVLALPSVALCSLNCWMHAGHHERPEFIPYHHLRIRTKPFSWGDGNHTLFHNPHVNPLPTGYEQP