wanglab/gogpt-training-data huggingface dataset:
Protein: Serine protease 3 (EC 3.4.21.-) (Protein Jonah 99Ci) (P17207)
Organism: Drosophila melanogaster (Fruit fly)
Function: Its major function may be to aid in digestion.
Interaction partners:
- Peptidase S1 domain-containing protein
- Jonah 25Bii, isoform A
- Jonah 25Biii
- Zinc carboxypeptidase A 1
- Trypsin theta
- Jonah 25Bi
- Peptidoglycan-recognition protein SC2
- Alpha-mannosidase
- trypsin
- Jonah 99Fii
Sequence:
MRGLTLLSLAFLGVCSALTVPHSLVHPRDLEIRHGGIEGRITNGNLASEGQVPYIVGVSLNSNGNWWWCGGSIIGHTWVLTAAHCTAGADEASLYYGAVNYNEPAFRHTVSSENFIRYPHYVGLDHDLALIKTPHVDFYSLVNKIELPSLDDRYNSYENNWVQAAGWGAIYDGSNVVEDLRVVDLKVISVAECQAYYGTDTASENTICVETPDGKATCQGDSGGPLVTKEGDKLIGITSFVSAYGCQVGGPAGFTRVTKYLEWIKEETGIYY
Protein: RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1) (Q1K9H5)
Organism: Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
Subcellular location: Host nucleus {ECO:0000256|HAMAP-Rule:MF_04065}. Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04065}.
Interaction partners:
Sequence:
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFETSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMNKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKRKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRHTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVNRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTHSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVNHKDIESVNNAVIMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK
Protein: Carotenoid 9,10(9',10')-cleavage dioxygenase 1 (EC 1.14.99.n4) (AtCCD1) (Neoxanthin cleavage enzyme NC1) (AtNCED1) (O65572)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cleaves a variety of carotenoids symmetrically at both the 9-10 and 9'-10' double bonds. Active on beta,beta-carotene, lutein, zeaxanthin, all-trans-violaxanthin, 9-cis-violaxanthin and 9'-cis-neoxanthin. With most substrates, the carotenoid is symmetrically cleaved. Probably not involved in abscisic acid biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12834401, ECO:0000269|PubMed:16507088}. Note=On the exterior surface of the plastids.
Interaction partners:
- Phytoene synthase 1, chloroplastic
- Zeaxanthin epoxidase, chloroplastic
- Zeta-carotene desaturase, chloroplastic/chromoplastic
- Prolycopene isomerase, chloroplastic
- Lycopene beta cyclase, chloroplastic
- 15-cis-zeta-carotene isomerase, chloroplastic
- 15-cis-phytoene desaturase, chloroplastic/chromoplastic
- Lycopene epsilon cyclase, chloroplastic
- Protein LUTEIN DEFICIENT 5, chloroplastic
- 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
Sequence:
MAEKLSDGSSIISVHPRPSKGFSSKLLDLLERLVVKLMHDASLPLHYLSGNFAPIRDETPPVKDLPVHGFLPECLNGEFVRVGPNPKFDAVAGYHWFDGDGMIHGVRIKDGKATYVSRYVKTSRLKQEEFFGAAKFMKIGDLKGFFGLLMVNVQQLRTKLKILDNTYGNGTANTALVYHHGKLLALQEADKPYVIKVLEDGDLQTLGIIDYDKRLTHSFTAHPKVDPVTGEMFTFGYSHTPPYLTYRVISKDGIMHDPVPITISEPIMMHDFAITETYAIFMDLPMHFRPKEMVKEKKMIYSFDPTKKARFGVLPRYAKDELMIRWFELPNCFIFHNANAWEEEDEVVLITCRLENPDLDMVSGKVKEKLENFGNELYEMRFNMKTGSASQKKLSASAVDFPRINECYTGKKQRYVYGTILDSIAKVTGIIKFDLHAEAETGKRMLEVGGNIKGIYDLGEGRYGSEAIYVPRETAEEDDGYLIFFVHDENTGKSCVTVIDAKTMSAEPVAVVELPHRVPYGFHALFVTEEQLQEQTLI
Protein: Protein Wnt-7a (O00755)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
- Frizzled-7
- Frizzled-5
- Frizzled-4
- Wnt inhibitory factor 1
- Frizzled-9
- Low-density lipoprotein receptor-related protein 6
- Frizzled-10
- Protein-serine O-palmitoleoyltransferase porcupine
- Tyrosine-protein kinase RYK
Sequence:
MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK
Protein: Voltage-dependent calcium channel gamma-1 subunit (Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma) (Q06432)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P19518}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19518}.
Interaction partners:
- Voltage-dependent calcium channel subunit alpha-2/delta-1
- Voltage-dependent L-type calcium channel subunit beta-1
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Voltage-dependent calcium channel gamma-4 subunit
- Voltage-dependent calcium channel subunit alpha-2/delta-2
- Voltage-dependent calcium channel gamma-7 subunit
- Voltage-dependent calcium channel gamma-3 subunit
- Voltage-dependent calcium channel gamma-8 subunit
- Voltage-dependent calcium channel gamma-2 subunit
Sequence:
MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRICTKRIPMDDSKTCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMIDSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRMPRNPWESCMDAEPEH
Protein: Histone-lysine N-methyltransferase ATX4 (EC 2.1.1.-) (Protein SET DOMAIN GROUP 16) (Trithorax-homolog protein 4) (TRX-homolog protein 4) (Trithorax 4) (Q9SUE7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone methyltransferase.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Protein TRAUCO
- Protein RBL
- Histone-lysine N-methyltransferase ATX2
- Histone H3-lysine
- E3 ubiquitin-protein ligase JMJ24
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- Protein ANTHESIS POMOTING FACTOR 1
- Lysine-specific demethylase JMJ26
- Lysine-specific demethylase REF6
- Methyl-CpG-binding domain-containing protein 9
Sequence:
MIIKRKFKTQIPSLERCKLGNESRKKKRKLNLGGGGYYYPLNLLGEIAAGIVPGNGRNGFSASWCTEVTKPVEVEESLSKRRSDSGTVRDSPPAEVSRPPLVRTSRGRIQVLPSRFNDSVLDNWRKDSKSDCDLEEEEIECRNEKVVSFRVPKATNLKSKELDRKSKYSALCKEERFHEQHNDEARARVDEKLPNKKGTFGPENFYSGDLVWAKSGRNEPFWPAIVIDPMTQAPELVLRSCIPDAACVVFFGHSGNENERDYAWVRRGMIFPFVDYVARFQEQPELQGCKPGNFQMALEEAFLADQGFTEKLMHDIHLAAGNSTFDDSFYRWIQETAVSNQELNNNAPRQGLLKKHRNPLACAGCETVISFEMAKKMKDLIPGDQLLCKPCSRLTKSKHICGICKKIRNHLDNKSWVRCDGCKVRIHAECDQISDRHLKDLRETDYYCPTCRAKFNFDLSDSEKQNSKSKVAKGDGQMVLPDKVIVVCAGVEGVYFPRLHLVVCKCGSCGPKKKALSEWERHTGSKSKNWKTSVKVKSSKLALEDWMMNLAELHANATAAKVPKRPSIKQRKQRLLAFLSETYEPVNAKWTTERCAVCRWVEDWDYNKIIICNRCQIAVHQECYGARHVRDFTSWVCKACERPDIKRECCLCPVKGGALKPTDVETLWVHVTCAWFQPEVCFASEEKMEPAVGILSIPSTNFVKICVICKQIHGSCTQCCKCSTYYHAMCASRAGYRMELHCLEKNGQQITKMVSYCAYHRAPNPDNVLIIQTPSGAFSAKSLVQNKKKGGSRLISLIREDDEAPAENTITCDPFSAARCRVFKRKINSKKRIEEEAIPHHTRGPRHHASAAIQTLNTFRHVPEEPKSFSSFRERLHHLQRTEMDRVCFGRSGIHGWGLFARRNIQEGEMVLEYRGEQVRGSIADLREARYRRVGKDCYLFKISEEVVVDATDKGNIARLINHSCTPNCYARIMSVGDEESRIVLIAKANVAVGEELTYDYLFDPDEAEELKVPCLCKAPNCRKFMN
Protein: DNA-directed RNA polymerase I subunit rpa43 (RNA polymerase I subunit A43) (DNA-dependent RNA polymerase 19 kDa polypeptide) (O43036)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase I subunit rpa1
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I and III subunit RPAC2
- Probable DNA-directed RNA polymerase I subunit RPA2
- RNA polymerase I-specific transcription initiation factor rrn3
Sequence:
MPDLSLYKQTVDLYLSIAPGHSRDPLNAIQEHMDSMILSKLPRINGIVLAYDNIRFLEKSAKVMYDSPFSFIWVRVDVLVFSPKKGDCLEGKINLVSPSHIGLLILGIFNASIPRKSIPKDWIFIEPDTTEEQGRWKTNDGNILEPGKDLEFVVDGIQREAGLTMVQGTLANS
Protein: Enhancer of polycomb-like protein (Q0E9C2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361124}.
Interaction partners:
Sequence:
MSKLSFRARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICTGLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQQQRLELTELKFEQMMDRLEKSSGQTVVTLNEAKSLLNQDDETSISVYDYWLNKRLKMQHPLILTVKTESRPGASSNNPYLAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLQRATTILEMVRRREETKRDHLKMTVNIFEKRVEMRDFNGAVYSELNSQYKNTRPAYNPLYTNQYSQGAAAVGTAGAILAALPTGLLPGGAGAAGNANVFGSASQYLNSSNLTMDAISGSGNGNSSRKEKRPYKKRKHKLPRDKQQHQQQQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAANDSIADSEEEDYFGAGAQNGNKLGSESEEETPFAFRRRSSCVYLPTRQRDGRYPWDSADEDMAPSGACSDAKYRYTLTSLNYPRPRCIGFARRRLGRGGRILLDRATTNFDDFWSQLDYTVMESVTVNKCRDKIKQRDPDQLCKPSSPPTVVDLVPAGKPVDGEHPVPELIKEEPSSDTEKPVAATESGRESKERELEEKFENDVDDEFVASDDENVSRLGIYSSAVTLPQSCADLRQKRRRLRRKKQQLRELNAAKRLKRSSEAVATAEDVQLEDEDTKPDLRPLPRAYLQRLALILGQKLKVEEDDNTEVSENVAPELLEMNDPEQLQPPRANHQQHHRSNHNNNNNTVLNNNNSSSSNVMNKDVSISEKINVIKQEAEELVGGKCEDQPVASTSAAAAAARAAEAAAAAEAASSTTTLAAPNPGPSLEEVAKTIKREMIDADDSNEPLSSIRTAAVMLSTQTSVSELMDDEAEDDVNLAQLSSIIRHTAVKKELEAQQHQQQVQHEQMQAARKMEEDEAAPCLNQLPDVIRLRNIRNSQVHARPKDLFVQAPVDEEFNADYMGGLSPTSSQRLDICNELLSEIRRDWLHFRPKTPTDELSDSQDCEVGKTCDSHAVDWTQDTPISVELNRLGKREAEESDSSSYFLSSGFKYRDLESDAQLLQTVQAQDYARGSSKSPNCSGSGSGSALEFNLSGGDSLNDINNLLGCDDEDDNHEHMLDNILQECAMDDPKALNQATNFWNGILDGEAAVDEVEMADQLLDCIDEKKSKVGAADTSKRAGRNRKARLIQAPVGSSAFTVCPTAETLKERELFFSQAPPVEVPPKEKTPAEVELPEVVVKETANLPVKVEAVEKPQSEVLPVAPQPQQLQPQAITLPTTQLINIPAQISTQKQHQQPQVTQLLNQFANAGPQIIARTEYGGGAAVGDIVTITPHTGSSPLPTLTAQQQLQHQLAQAQLRNVTVQQRQATPQNPNQNQNPQQQLLFQMQRDPSRSLTPLQAAGAGATGNHLIYTTSCGEIVTAGAAASASQKVTYAIQKAGVSSGGATTASIGPNTVITLSNVKVQNDDISSGGSGNSGSSVNIINTASGQQLAVHSIAGMQQQGQQQVQQVTTSTPLLVATPTRNNVQQQQQQLVQQQPIVWRQVSGTNTAVATTAVLSTTVDSSPKAVTNQILWTSRATQKRQLNGPENTDINKLLLNRKLPRKQQIQQQHQQIQLTKQQLQQLVQHEELDDLVATSTGNSGDQMETGDGLQQQQQQQQQQQQLQKLSKVIKMSQFPLLVSDVSLQQQQSVSGQAQQQQLKPNSAAAIAANHNYSLHPASTAIITAQATPQQANKIFLTSSNSGGGGSAGNFTIATASELQAAAAGQKLHYKELPNSNLKLNFVSSAGTGEQTQQVGATTVLLNKSQQQQQQQQHQKLKTLATTGNSQTGQGDKRVLYTSLLNVKPLQKNNSGQMQMQLGPGGLQQVLRGRLNNSAIITRTLPLGTTVNSTGGAVGPTTTTIRQLVTTNANNVSSQDGNLLSAKEVGKALTVEQVIASANNGGVVLPTSNNNNNNNGSGAGGNGGPLNSGVNATGAGGGGSTGAGVGGAGVTSTINR
Protein: Protein tweety homolog 1 (mTTY1) (Volume-regulated anion channel subunit Ttyh1) (Q9D3A9)
Organism: Mus musculus (Mouse)
Function: Probable chloride channel. May be involved in cell adhesion (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:31138989, ECO:0000269|PubMed:36042377}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPHGAKSPPPGGGCVTWSCIAALLVGCAGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDDVVLETVERLGEAVKTELTTLEEVLSVRMELVAATRGARRQAEAAAQYLQGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYVLLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDTYVLNLTQEETGLSSDILSYYFLCNQAVSNPFQQRLTLSQRALASIHSQLQGLEREAIPQFSAAQKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGSALRGLCEDALEGLLFLMLFSLLSAGALATTLCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI
Protein: Magnesium transporter NIPA1 (NIPA magnesium transporter 1) (Nipa1 protein) (Non imprinted in Prader-Willi/Angelman syndrome 1) (Q5XJN7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Gamma-tubulin complex component
- Atlastin-1
- Cytoplasmic FMR1-interacting protein 1 homolog
- Spartin
- Spastin
- Atlastin GTPase 2.
- Receptor expression-enhancing protein.
- Maspardin
- Atlastin 3
- Acetyl-coenzyme A transporter 1
Sequence:
MDETPFPVVGVVIAVVSSFINGSTFVLQKKGILRARKSGGTYLADCVWWCGTLAMIVGQIGNFLAYNVAPAVVVTPLGALGVLFGAVLASWLLQEHLDLIGKLGCILCCCGAVVLIIHSPKSENVTSRAELEERLMDPVFQVYISLVVILLIILIGWLSPAHGKSNIMVYVGICSLLGSFTVPSSKGLGLAAQEAFSQTPSSDGRAFFLFLGLLGVLVVSILIQFTFINKALENFSSNMFEAIYYVTFTSCVILASAVLFREWTALGIVDCLGILCGFVTVSVGVALLRISQEAKLTWSQTKDKEN
Protein: Synapsin-1 (Synapsin I) (O88935)
Organism: Mus musculus (Mouse)
Function: Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (By similarity). Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level (By similarity).
Subcellular location: Synapse {ECO:0000269|PubMed:11571277}. Golgi apparatus {ECO:0000269|PubMed:11571277}. Presynapse {ECO:0000250|UniProtKB:P09951}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:P09951}. Note=Dissociates from synaptic vesicles and redistributes into the axon during action potential firing, in a step that precedes fusion of vesicles with the plasma membrane. Reclusters to presynapses after the cessation of synaptic activity. {ECO:0000250|UniProtKB:P09951}.
Interaction partners:
- Synaptophysin
- Vesicle-associated membrane protein 2
- Synaptosomal-associated protein 25
- Ras-related protein Rab-3A
- Disks large homolog 4
- Synaptotagmin-1
- DnaJ homolog subfamily C member 5
- Syntaxin-1A
- Neuromodulin
- Vesicular glutamate transporter 1
Sequence:
MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPSAASPGATPGSATASAERASTAAPVASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAAARVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMTQALPRQPQRDASPGRGSHSQSSSPGALTLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTAAPQQSASQATPVTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGAPQATRQASISGPAPTKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPGPRTGPPTTQQPRPSGPGPAGRPAKPQLAQKPSQDVPPPITAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD
Protein: Vacuolar protein 8 (P39968)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:10888680, ECO:0000269|PubMed:9490720}; Lipid-anchor {ECO:0000269|PubMed:9490720}. Note=Localizes at sites of nucleus-vacuole junctions. {ECO:0000269|PubMed:10888680}.
Interaction partners:
- Nucleus-vacuole junction protein 1
- vacuole-related protein 17
- Autophagy-related protein 13
- Putative lipase ATG15
- Membrane-anchored lipid-binding protein LAM6
- Palmitoyltransferase PFA3
- Myosin-2
- Biogenesis of lysosome-related organelles complex 1 subunit VAB2
- Autophagy-related protein 11
- Serine/threonine-protein kinase ATG1
Sequence:
MGSCCSCLKDSSDEASVSPIADNEREAVTLLLGYLEDKDQLDFYSGGPLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQVSREVLEPILILLQSQDPQIQVAACAALGNLAVNNENKLLIVEMGGLEPLINQMMGDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSKHIRVQRNATGALLNMTHSEENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLAQTEPRLVSKLVSLMDSPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRLLDYKDSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDSPVSVQSEISACFAILALADVSKLDLLEANILDALIPMTFSQNQEVSGNAAAALANLCSRVNNYTKIIEAWDRPNEGIRGFLIRFLKSDYATFEHIALWTILQLLESHNDKVEDLVKNDDDIINGVRKMADVTFERLQRSGIDVKNPGSNNNPSSNDNNSNNNDTGSEHQPVEDASLELYNITQQILQFLH
Protein: Probable prephenate dehydrogenase [NADP(+)] (PRDH) (EC 1.3.1.13) (O60078)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Histidinol-phosphate aminotransferase
- Pyrroline-5-carboxylate reductase
- Chorismate mutase
- Putative prephenate dehydratase
- Chorismate synthase
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Probable phosphoserine phosphatase
- Aromatic amino acid aminotransferase C569.07
- Aromatic amino acid aminotransferase C1773.13
Sequence:
MKETFQVGIIGFGDMGRLYAEYISKAGWRVNVCDRPENYESIQATYGNGGYTVLKDGFQVSRTSDYILYSVEAEHIDKVVALYGPATKVGAIVGGQTSCKAPEMNAFEKYLPEDVDIISCHSMHGPKVNPKSQPLVIIRHRASDEHFEIVNEILSCFKSSVVYLSAKEHDRITADTQAVTHAAFLTMGLAWHANNQYPWEINRWCGGIENIKMNLSMRIYSSKWHVYAGLAILNPEAQRQIQQYASSVTELFKLAISGKAKEYEDRIRNAGKFVFGENMDRNSSGLLLSDELLDQYSISNIPKDESKRNSHLSILAIVDSWSKLGIHPQNHMICSTPLFRLWVGVSEYVFRHPGLLDSCIYTATKHNDFSPDDLEFVVAVRSWSECVAAKDFTTYKKRFLETQEYFRPRFEEATRVGNAMISKLLENLQKM
Protein: Phosphotransferase (EC 2.7.1.-) (Q9GNH8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKFLALDLGGTNFRVLLIHLQENNDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEHNVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINKMDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSGRGAALVAAVACREDILNGKK
Protein: DNA topoisomerase 4 subunit B (EC 5.6.2.2) (Topoisomerase IV subunit B) (Q9HUJ8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Interaction partners:
- DNA topoisomerase 4 subunit A
- DNA gyrase subunit A
- Phytase-like domain-containing protein
- DNA topoisomerase 1
- DNA topoisomerase
- TIGR02281 family clan AA aspartic protease
- Esterase
- Methionine--tRNA ligase
- DNA polymerase I
- Beta-lactamase
Sequence:
MATYNADAIEVLSGLDPVRKRPGMYTDTTRPNHLAQEVIDNSVDEALAGHAKSVQVILHQDNSLEVIDDGRGMPVDIHPEEGVPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSTRVEVRVKRDANEYRMTFADGFKDSDLEVIGTVGKRNTGTSVHFWPDPKYFDSAKFSVSRLKHVLKAKAVLCPGLSVVFEDKNTGERVEWHFEDGLRSYLTDAVAELPRLPDEPFCGNLEGSKEAVSWALLWLPEGGESVQESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNLLPRGVKLAPEDVWERIAFVLSMKMQEPQFSGQTKERLSSREAAAFVSGVVKDAFSLWLNEHAEIGLQLAELAISNAGRRLKAGKKVERKKITQGPALPGKLADCAGQEPMRAELFLVEGDSAGGSAKQARDKEFQAIMPLRGKILNTWEVDGGEVLASQEVHDIAVAIGVDPGASDLAQLRYGKICILADADSDGLHIATLLCALFVRHFRPLVEAGHVYVAMPPLYRIDLGKDIYYALDEAERDGILERLAAEKKRGKPQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTLEDATGTLEIMDMLLAKKRAGDRKSWLESKGNLAEVLV
Protein: BEL1-like homeodomain protein 7 (BEL1-like protein 7) (Q9SIW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein knotted-1-like 7
- Homeobox protein knotted-1-like 1
- Protein KNATM
- Transcription repressor OFP3
Sequence:
MATYYKTGSSEIYSRPEFVPGNAMNYTNSFTETFPRDSTNNVSPSKEIQVLSSLGGVSQMVEIQDSGSWRDQEDNDRNRFPVMRRLGLSSQIETSRGNNNNEYATQVVSGFTRTIHNSKYLKAAQELLDETVNVKKALKQFQPEGDKINEVKEKNLQTNTAEIPQAERQELQSKLSKLLSILDEVDRNYKQYYHQMQIVVSSFDVIAGCGAAKPYTALALQTISRHFRCLRDAISGQILVIRKSLGGEQDGSDGRGVGISRLRNVDQQVRQQRALQRLGVMQPHTWRPQRGLPDSSVLVLRAWLFEHFLHPYPKDSDKIMLARQTGLSRGQVSNWFINARVRLWKPMVEEMYKEEFTDALQENDPNQSSENTPEITEIQELQTESSSNNGHVPGVASSSMRQNTVAHGGDRFMMVTDMTRNGNGGMSLTLGIQNSDARGDVPMSGGIDNYKNTISGTDLQYLNSRNHQHQIGSSQLLHDFVA
Protein: Wall-associated receptor kinase-like 22 (EC 2.7.11.-) (Q8RY17)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Required during plant's response to pathogen infection.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Receptor-like protein 3
- Wall-associated receptor kinase galacturonan-binding protein
- Disease resistance protein ADR2
- CASP-like protein 2A1
- Putative methylesterase 14, chloroplastic
Sequence:
MKRRRLFFSVLLSILTLFINGPLITTAQSPPSSSTSCNRICGGIEIPFPFGIGRRDCFLNDWYEVVCNSTTSGKSLAPFLYKINRELVSITLRSSIDSSYGVVHIKSPVTSSGCSQRPVKPLPLNLTGKGSPFFITDSNRLVSVGCDNRALITDIESQITGCESSCDGDKSRLDKICGGYTCCQAKIPADRPQVIGVDLESSGGNTTQGGNCKVAFLTNETYSPANVTEPEQFYTNGFTVIELGWYFDTSDSRLTNPVGCVNLTETGIYTSAPSCVCEYGNFSGFGYSNCYCNQIGYRGNPYLPGGCIDIDECEEGKGLSSCGELTCVNVPGSWRCELNGVGKIKPLFPGLVLGFPLLFLVLGIWGLIKFVKKRRKIIRKRMFFKRNGGLLLKQQLTTRGGNVQSSKIFSSKELEKATDNFNMNRVLGQGGQGTVYKGMLVDGRIVAVKRSKVLDEDKVEEFINEVGVLSQINHRNIVKLMGCCLETEVPILVYEHIPNGDLFKRLHHDSDDYTMTWDVRLRISVEIAGALAYLHSAASTPVYHRDVKTTNILLDEKYRAKVSDFGTSRSINVDQTHLTTLVAGTFGYLDPEYFQTSQFTDKSDVYSFGVVLVELITGEKPFSVMRPEENRGLVSHFNEAMKQNRVLDIVDSRIKEGCTLEQVLAVAKLARRCLSLKGKKRPNMREVSVELERIRSSPEDLELHIEEEDEEECAMEINMDDSWSVDMTAPASLFDLSPKLDVEPLVPQRTW
Protein: Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) (O35343)
Organism: Mus musculus (Mouse)
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O00629}. Nucleus {ECO:0000250|UniProtKB:O00629}.
Interaction partners:
- Transcription factor p65
- Importin subunit alpha-4
- Importin subunit beta-1
- Exportin-2
- Nuclear factor NF-kappa-B p105 subunit
- Importin subunit alpha-5
- Regulator of chromosome condensation
- Importin subunit alpha-1
- GTP-binding nuclear protein Ran
- GTP-binding nuclear protein Ran
Sequence:
MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPQEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDQAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPESVQGGTFGFNSSTNVPTEGFQF