wanglab/gogpt-training-data huggingface dataset:
Protein: Probable mannan endo-1,4-beta-mannosidase A (EC 3.2.1.78) (Endo-beta-1,4-mannanase A) (A2QKT4)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Function: Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MKLSNALLTLASLALANVSTALPKASPAPSTSSSAASTSFASTSGLQFTIDGETGYFAGTNSYWIGFLTDNADVDLVMGHLKSSGLKILRVWGFNDVTSQPSSGTVWYQLHQDGKSTINTGADGLQRLDYVVSSAEQHDIKLIINFVNYWTDYGGMSAYVSAYGGSGETDFYTSDTMQSAYQTYIKTVVERYSNSSAVFAWELANEPRCPSCDTSVLYNWIEKTSKFIKGLDADRMVCIGDEGFGLNIDSDGSYPYQFSEGLNFTMNLGIDTIDFGTLHLYPDSWGTSDDWGNGWITAHGAACKAAGKPCLLEEYGVTSNHCSVEGSWQKTALSTTGVGADLFWQYGDDLSTGKSPDDGNTIYYGTSDYQCLVTDHVAAIGSA
Protein: 10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (A0A494C1M4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MCLRVCKFIGRQIRGRWLPGEKHVLVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGKADPLALAAEKDGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGEPLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVPIIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGEDQEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLEY
Protein: Putative cyclic nucleotide-gated ion channel 19 (Cyclic nucleotide-binding transporter 2) (Q9LDR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative cyclic nucleotide-gated ion channel.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Glutamate receptor 3.3
- Hyperosmolality-gated Ca2+ permeable channel 1.1
- Two pore calcium channel protein 1
- Glutamate receptor 3.5
- Glutamate receptor 3.2
- Glutamate receptor 2.1
Sequence:
MAHTRTFTSRNRSVSLSNPSFSIDGFDNSTVTLGYTGPLRTQRIRPPLVQMSGPIHSTRRTEPLFSPSPQESPDSSSTVDVPPEDDFVFKNANLLRSGQLGMCNDPYCTTCPSYYNRQAAQLHTSRVSASRFRTVLYGDARGWAKRFASSVRRCLPGIMNPHSKFVQVWTRVLAFSSLVAIFIDPLFFFLLLIQQDNKCIAIDWRATKVLVSLRSITDLIFFINILLQFRLAYVAPESRIVGAGQLVDHPRKIARHYFRGKFLLDMFIVFPIPQIMILRIIPLHLGTRREESEKQILRATVLFQYIPKLYRLLPLLAGQTSTGFIFESAWANFVINLLTFMLAGHAVGSCWYLSALQRVKKCMLNAWNISADERRNLIDCARGSYASKSQRDLWRDNASVNACFQENGYTYGIYLKAVNLTNESSFFTRFSYSLYWGFQQISTLAGNLSPSYSVGEVFFTMGIIGLGLLLFARLIGNMHNFLQSLDRRRMEMMLRKRDVEQWMSHRRLPEDIRKRVREVERYTWAATRGVNEELLFENMPDDLQRDIRRHLFKFLKKVRIFSLMDESVLDSIRERLKQRTYIRSSTVLHHRGLVEKMVFIVRGEMESIGEDGSVLPLSEGDVCGEELLTWCLSSINPDGTRIKMPPKGLVSNRNVRCVTNVEAFSLSVADLEDVTSLFSRFLRSHRVQGAIRYESPYWRLRAAMQIQVAWRYRKRQLQRLNTAHSNSNR
Protein: Geissoschizine synthase (CrGS) (EC 1.3.1.36) (Alcohol dehydrogenase 14) (CrADH14) (W8JWW7)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. catharanthine, tabersonine, vincadifformine, vindoline, vincristine, quinine and strychnine) biosynthesis pathway. Catalyzes iminium reduction on 4,21-dehydrogeissoschizine to produce 19E-geissoschizine, precursor of catharanthine and tabersonine derivatives. May also catalyze the production of reactive intermediate used by the HL1, HL2, HL3 and HL4 to form catharanthine, vincadifformine and tabersonine.
Interaction partners:
Sequence:
MAGETTKLDLSVKAVGWGAADASGVLQPIKFYRRVPGERDVKIRVLYSGVCNFDMEMVRNKWGFTRYPYVFGHETAGEVVEVGSKVEKFKVGDKVAVGCMVGSCGQCYNCQSGMENYCPEPNMADGSVYREQGERSYGGCSNVMVVDEKFVLRWPENLPQDKGVALLCAGVVVYSPMKHLGLDKPGKHIGVFGLGGLGSVAVKFIKAFGGKATVISTSRRKEKEAIEEHGADAFVVNTDSEQLKALAGTMDGVVDTTPGGRTPMSLMLNLLKFDGAVMLVGAPESLFELPAAPLIMGRKKIIGSSTGGLKEYQEMLDFAAKHNIVCDTEVIGIDYLSTAMERIKNLDVKYRFAIDIGNTLKFEE
Protein: Phosphoinositide phospholipase C (EC 3.1.4.11) (Q5BFL6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- 1-phosphatidylinositol-4-phosphate 5-kinase
- Phosphatidylinositol 3-kinase VPS34
- 1-phosphatidylinositol 4-kinase
- Protein qutG
- Kinase
- CDP-diacylglycerol-inositol 3-phosphatidyltransferase PIS
- Phosphatase family protein
- phosphoinositide 5-phosphatase
- Phosphoinositide phosphatase
Sequence:
MTYAATSSTSAVHGDPQASLKLAASRPRPKLHHIFTSSAIPAALAPTYASSYTTTPTSLPPSCTPSNDSSPLGTPFLSAVDSLRDRVTPLPPTSAPSLELGDSIMAVPATISASYPGDTVIPNSIKGTGLMRRISRGAANKLTRRRTSNSHNDKRDRSSGPVIMRRRSDSKTGTQTGRDSALDSSYEEDSNDALDALGGWAGSEASSVPNDNTPTVPRNPAVVAPTVDSAIQRGTILTKVTKKRRKQVRFLLNLDAGKVYWDPSNPAKRFYIDDVKEIRVGADARNYREEHQVSQDAENRWFTIVIADAERSKGRPVKTIHLIAPNERLLKLWTTTLEYISRYRVGLMAGLAASNQNESVLKAHWQREMTRLFPNGMKAGDTETLDFAAVESVCQSLHINCSQNMLRAHFLKADTGKHGKLNFDEFKDFVTRLRERRDVREIFRSHADDHREGLTLEEFLIFLRDVQKEDIDSDRAYWISVFDKLVRKSKSRTQSPTGTSSEDQSSRMSLDAFSSFLASARNGVYASRSPQSRFDRPLNEYFISSSHNTYLLGRQVAGSSSTEAYISALTQGCRCIEIDCWDGADGRPIVSHGRTMTTSVLFADCITVINRYAFFSSEFPLVISLEVHCNPEQQIAMVKIMKETFGEKLILEPLSNSFVLPSPEELKRRILIKVKTCDETENIRQDPITSFHGRKRSSSSPFIRPSMSDGPTLPNLPSLSSPPTIGADCPGPFLVPERRSLTTTSISSATEDSDGGLVSVRKERRRRQKSKITKPLSDLGVYTRGYKWHSFASAESQAFNHVYSFAERSFESICREPSNKALFEKHNSKYLTRVYPSGFRLRSSNFDPLKFWRRGVQMAALNWQTYDIGMQMNQAMFAAGSDRTGYVLKPESLRVVSSEKDTRITERKLVRFSVDVISAQQLPRPQNMSSDGNINPYVEIEMFSADDRGQSFAFGEGGMNASARNGMSGIGFPHRRRTKIEQRNGYSPNFNESFRLSLETKYPDLVFVRWTVWSSLDGRSTGTNGSVQLATFTAKLTSLSQGYRYLPLYDGSGDQYIFSTLFCKISKEEPISVRRLNADELRAERLGILRQIGQTVFKRTSSTEREKQDQSDKGTETPICLEGKEISPALTPTISTTSTAS
Protein: Histone-lysine N-methyltransferase ATX2 (EC 2.1.1.-) (Protein SET DOMAIN GROUP 30) (Trithorax-homolog protein 2) (TRX-homolog protein 2) (P0CB22)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone methyltransferase. Dimethylates 'Lys-4' of histone H3 (H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Methylates only a limited fraction of nucleosomes of target genes (e.g. NAP and XTH33). Involved in epigenetic regulation of the floral repressor FLC and FT to prevent the transition from vegetative to reproductive development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Protein TRAUCO
- Protein RBL
- Histone-lysine N-methyltransferase ATX3
- Histone-lysine N-methyltransferase ATX4
- Histone-lysine N-methyltransferase ATX5
- COMPASS-like H3K4 histone methylase component WDR5A
- Lysine-specific demethylase JMJ26
- Lysine-specific demethylase JMJ28
- E3 ubiquitin-protein ligase JMJ24
- Histone H3-lysine
Sequence:
MISMSCVPKEEEGEDTQIKTELHDHAADNPVRYASLESVYSVSSSSSSLCCKTAAGSHKKVNALKLPMSDSFELQPHRRPEIVHVYCRRKRRRRRRRESFLELAILQNEGVERDDRIVKIESAELDDEKEEENKKKKQKKRRIGNGELMKLGVDSTTLSVSATPPLRGCRIKAVCSGNKQDGSSRSKRNTVKNQEKVVTASATAKKWVRLSYDGVDPKHFIGLQCKVFWPLDAVWYPGSIVGYNVETKHHIVKYGDGDGEELALRREKIKFLISRDDMELLNMKFGTNDVVVDGQDYDELVILAASFEECQDFEPRDIIWAKLTGHAMWPAIIVDESVIVKRKGLNNKISGGRSVLVQFFGTHDFARIQVKQAVSFLKGLLSRSPLKCKQPRFEEAMEEAKMYLKEYKLPGRMDQLQKVADTDCSERINSGEEDSSNSGDDYTKDGEVWLRPTELGDCLHRIGDLQIINLGRIVTDSEFFKDSKHTWPEGYTATRKFISLKDPNASAMYKMEVLRDAESKTRPVFRVTTNSGEQFKGDTPSACWNKIYNRIKKIQIASDNPDVLGEGLHESGTDMFGFSNPEVDKLIQGLLQSRPPSKVSQRKYSSGKYQDHPTGYRPVRVEWKDLDKCNVCHMDEEYENNLFLQCDKCRMMVHTRCYGQLEPHNGILWLCNLCRPVALDIPPRCCLCPVVGGAMKPTTDGRWAHLACAIWIPETCLLDVKKMEPIDGVKKVSKDRWKLLCSICGVSYGACIQCSNNTCRVAYHPLCARAAGLCVELADEDRLFLLSMDDDEADQCIRLLSFCKRHRQTSNYHLETEYMIKPAHNIAEYLPPPNPSGCARTEPYNYLGRRGRKEPEALAGASSKRLFVENQPYIVGGYSRHEFSTYERIYGSKMSQITTPSNILSMAEKYTFMKETYRKRLAFGKSGIHGFGIFAKLPHRAGDMVIEYTGELVRPPIADKREHLIYNSMVGAGTYMFRIDNERVIDATRTGSIAHLINHSCEPNCYSRVISVNGDEHIIIFAKRDVAKWEELTYDYRFFSIDERLACYCGFPRCRGVVNDTEAEERQANIHASRCELKEWTES
Protein: Gamma-glutamylpolyamine synthetase GlnA3 (EC 6.3.1.-) (Q9KZC7)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Function: Involved in the catabolism of polyamines. Catalyzes the ATP-dependent gamma-glutamylation of polyamines. Substrates include putrescine, cadaverine, spermidine and spermine, with a preference for long-chain polyamines spermidine and spermine. Is not able to compensate for the loss of glutamine synthetases (GSs). No complementation of the L-glutamine auxotrophy of an E.coli glnA mutant. Involved in morphological differentiation and in the production of secondary metabolites. Together with GlnA2, enables survival of S.coelicolor under exposure to high local environmental polyamine concentrations, which is toxic to the cells.
Interaction partners:
- Amidohydrolase-related domain-containing protein
- Glutamate synthase large subunit
- Glutamate dehydrogenase
- Uncharacterized protein
- assimilatory sulfite reductase
- Glutamine synthetase
- Gamma-glutamylethanolamide synthetase GlnA4
- Glutamine synthetase
- Carbamoyl phosphate synthase large chain
- Gamma-glutamylpolyamine synthetase GlnA2
Sequence:
MSESDPVPGGRPGEVERATALSGELTGQGVHGVVLAYVDTAGIARVKTVPTAKLAAAAAWGVGMSPVFDTFLADDSIVGTDVLGSPDGDLRLYPDLDRLTMLAAQPGWAWAPVDRITQEGAPHPACGRTVLRRIVAGAAERHGITFRAAVEVEWVVGRGDAGGDAFVPAVSGPAYGAARQVELSDCAADLLAALAAQGVDVEQFHPEYAAGQFEVSVGALGPVAAADHSVLVRQTIRAVSARHGLRVSFAPAVLGQGVGNGGHLHLSAWRDGTNLHAGGTARCGMTAEAESFVAGVLGHLPALTALTAPSPASRLRLRPSQWAGVFTAWGRETREAALRIVTGTAGIRDRAANLEVKPVDLAANPYLALASVIAAGLDGLASSAPLPEEITGDPARLDPAAAAARGVRRLPVTLTESVAAFRTDGVLREALGPVLADAVIAVRLGEAGSVEGLDDDGVAAAYRWKY
Protein: Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit) (P57789)
Organism: Homo sapiens (Human)
Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8BUW1}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Potassium channel subfamily K member 2
- Keratin, type II cytoskeletal 2 oral
- Potassium channel subfamily K member 9 channel 3)
- Potassium channel subfamily K member 3 channel 1)
- Potassium channel subfamily K member 18
Sequence:
MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN
Protein: Transcription initiation factor IIB (General transcription factor TFIIB) (Transcription factor E) (P29055)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Subcellular location: Nucleus.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB1
- Transcription initiation factor IIF subunit alpha
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- Transcription initiation factor IIE subunit alpha
- Transcription initiation factor IIE subunit beta
- DNA-directed RNA polymerase II subunit RPB4
- Transcription initiation factor IIF subunit beta
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
Sequence:
MMTRESIDKRAGRRGPNLNIVLTCPECKVYPPKIVERFSEGDVVCALCGLVLSDKLVDTRSEWRTFSNDDHNGDDPSRVGEASNPLLDGNNLSTRIGKGETTDMRFTKELNKAQGKNVMDKKDNEVQAAFAKITMLCDAAELPKIVKDCAKEAYKLCHDEKTLKGKSMESIMAASILIGCRRAEVARTFKEIQSLIHVKTKEFGKTLNIMKNILRGKSEDGFLKIDTDNMSGAQNLTYIPRFCSHLGLPMQVTTSAEYTAKKCKEIKEIAGKSPITIAVVSIYLNILLFQIPITAAKVGQTLQVTEGTIKSGYKILYEHRDKLVDPQLIANGVVSLDNLPGVEKK
Protein: Transforming acidic coiled-coil protein, isoform D (Q86BB5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MDFLANIIKRPKSIATTGISTNQPTTMEALEAASPADECSTPRDKGGVTLVSAHLDSLLESASEELQRLEGKHCELFMESISNPLPAPEDSTDSREEIQKFLSEINFNLNQLSPLAVKPSPKPTSMDQQKAMAAALGHQTAVPGGLKPEDDLVPKFGGLPEFDETQIPELAPLSTDMDTQLKSNHSDSDVFVECLSLHSERYTGDRSELEAYSSALNDVLEQQLSMTSVSTLGAEFNDPLAVSQHNNVSYEAMDVDDLNETMEMLKDVLNAEDRHLMQTHILSVTQSKPENNFVHYHPNQEQNRVELDQLAKHSKPNSDAKESESLVESVLSEESGTQSFEPKLTLSALDSTKDLAKHQEEMQTNTKDIFQKEKHHPVSSAQVKDAQNPKEPEKALNLKEASSELSTKSAKSLEYPNQEKQFSVAVESMERPCTAISLEQNASPAMEATEDRTVEELDQMDVDESMKVDDATVLNSCRQEQINAHSPVSSKFFLKLCVQNDTDCQDNKMDQKTAGKESALKMTEIELPVESVPSASLSPPTPALQAKIIELSLSPPIPTHRPKTAEELEFLALRELPLPDGVSTAGKVECKQLSHGLVPIVAVLPTPLYLDLKGNTTTASLPEPTSPSFPIKEPAEKQSHFPRSPRAQLEQKDMPYLEEAVVERSSHRKQSDFGVIAKSPIVFELTQPSPEKQHLNETLPMSEISPTSSNMTFDSGSITEDKSQKGTENIEPSSTLAVSLGSVDDKQRRTFSVVQPTKEEEEAKSRRTFCMENENPRRTFCMQQNASPAVEATEDTGADEVMDVDISMRADEVAVMKSHQQTWKERQAPISNSPPIPTHQRLNRPPEAISPVSPLGNGTVVLEEQTLSAKEQATLSASDEKDDVFLEHFGAISPVSDDMFKTSSASNNQAKFRVNADEETGGKGASAMIRKRSGTAGEQEEIFDAEFHDGVNNQNRSNSVPIDRSSLLLKFDPLLGAPVPVNHPNQQEQALQNILGSNQHQNRLLSPTLEEHETSDGNQSFGVISSAKDTAKKWDFKPPVDRTKKHVKMSVDVIDNDCNKTFDNSNTNTEDKTHNYNDMDELEKKIKNEVTRSEDIEKKLKEGELREEALIKRITEKDKTNAKLNGVIEAYEKAIAELISEKEQQAQLHERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQLEIANKKLDTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICEELIYGKGQGGSS
Protein: Transcriptional and immune response regulator (Thyroid cancer protein 1) (TC-1) (Q9NR00)
Organism: Homo sapiens (Human)
Function: Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression. Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:25985737}. Nucleus, nucleolus {ECO:0000269|PubMed:16424001}. Nucleus speckle {ECO:0000269|PubMed:16424001}. Nucleus {ECO:0000269|PubMed:16424001}. Note=Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013). {ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:17603013}.
Interaction partners:
- BAG family molecular chaperone regulator 4
- U6 snRNA-associated Sm-like protein LSm1
Sequence:
MKAKRSHQAVIMSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKAEERAKIIFAIDQDVEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH
Protein: Angiomotin (E7F8Q6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
Interaction partners:
Sequence:
MRAAASVSEDTSANNSGGSGHTVLQRLLQEQMRYGEGRNYLALQQQQQQGPVSGYPGPGSPADEHSMVPHIARQEPQGQELQVDSGMEKLSTRTAGGGGGSGGTGSLGGSCVSGQMQNPEDLPTYDQAKVQSQYFRGHQPQQPQPQMPPTVGAAFYVTGVTNSKVRPPEGRSTVQRMNGGKVHQDDGLKDLKQGHVRSLSERLMQLSLATSGVKAHAPVTSSPLSPQLPPPGLPGDYYKPTGPPHRGPPPDYPFKGMPSPPKQQQHHQPQHQEPGHFHPDHRGTSQPARTDIPHVRYQPPPEYGSFRSSKESSSHSQRSVHHHSPSSSVTSGGSLSRAQSSTLSSILAASHALPPMGHSGEPPFPIGARSSQGPGSHQGDPYGPGHPPHQRSHVFPHDHYGSAPRGLHMLQHQYHQQGPQQQQQQSPAQHYSHPLSMQGDPYAMLARAQQMVDMLSEENRLLKQELEVCGEKVSKLQKMETEIQMVSEAYENLAKSSTKREALEKTMRNKLEMEVRRVHDFNRDLRERMETANKQLAAKECEGTEDNRKTISQLLVQVKENQREKEKLEIELNSLRSTTEDQRRHIEIRDQALNNAQAKVVKLEEELKKKQVYVEKVERMQQALAQLQAACEKREQLEHRLRTRLERELESLRMQQRQGGSQSTVGPEFSTAALMEHLREKEERILALEADMTKWEQKYLEESVMRQFALDAAASVATQRDTSSAIISHSPSSSYDTSVEARIQKEEEEILMANRRCLDMESRIKNLHAQIIEKDAMIKVLHQRSRKEPASKLDTPAMRPSKSLMSIATGTGGSSGSGLLSHSLGLSGSSPITEERREDRSWKGSLGVLLGPEFRGDSLRTESISSSPSPVLPSTPMPLATHSKTGSRDSCTQTEKSQENSKPSTPALQNVPGPSRISSPSPVYIPDRIADVPVFHSSTLERRAPVQSLPPASVAAQDMDSDMVEILI
Protein: Ethylene-responsive transcription factor ERF015 (Q6NLD5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Octanoyltransferase LIP2p, chloroplastic
- Transmembrane protein
- Pentatricopeptide repeat-containing protein At1g02060
- GTPase ERA-like, chloroplastic
- Nucleolar histone methyltransferase-related protein
- DUF7650 domain-containing protein
- Protein kinase superfamily protein
- Putative methylesterase 6
- Methylesterase 7
- Mannan endo-1,4-beta-mannosidase 7
Sequence:
MPPSPPKSPFISSSLKGAHEDRKFKCYRGVRKRSWGKWVSEIRVPKTGRRIWLGSYDAPEKAARAYDAALFCIRGEKGVYNFPTDKKPQLPEGSVRPLSKLDIQTIATNYASSVVHVPSHATTLPATTQVPSEVPASSDVSASTEITEMVDEYYLPTDATAESIFSVEDLQLDSFLMMDIDWINNLI
Protein: Glutathione-regulated potassium-efflux system protein KefC (K(+)/H(+) antiporter) (P03819)
Organism: Escherichia coli (strain K12)
Function: Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Can also export rubidium, lithium and sodium.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01413, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2046548}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01413, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2046548}.
Interaction partners:
- Glutathione-regulated potassium-efflux system ancillary protein KefF
- Glutathione-regulated potassium-efflux system ancillary protein KefG
- Putative metabolite transport protein YaaU
- Glutathione-regulated potassium-efflux system protein KefB
- Na
- Voltage-gated potassium channel Kch
- Trk system potassium uptake protein TrkG
- Potassium-transporting ATPase potassium-binding subunit
- Potassium-transporting ATPase KdpC subunit
Sequence:
MDSHTLIQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLWKLRAAVFGCGALQMVICGGLLGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAIPLVAMIPLLATSSASTTMGAFALSALKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLLENPLRIVILLLGFLIIKIAMLWLIARPLQVPNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEEAREADEIDEEQPRVIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQLTEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAMVENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS
Protein: Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) (P62906)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}.
Interaction partners:
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein P1
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein eL30
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL43
Sequence:
MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY
Protein: L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (P00340)
Organism: Gallus gallus (Chicken)
Function: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
Subcellular location: Cytoplasm.
Interaction partners:
- Pyruvate kinase PKM
- Lipoyl-binding domain-containing protein.
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Malic enzyme.
- Pyruvate dehydrogenase E1 component subunit beta
- Pyruvate dehydrogenase E1 component subunit alpha
- Malic enzyme
- L-lactate dehydrogenase B chain
- 2-oxoisovalerate dehydrogenase subunit alpha
Sequence:
MSLKDHLIHNVHKEEHAHAHNKISVVGVGAVGMACAISILMKDLADELTLVDVVEDKLKGEMLDLQHGSLFLKTPKIISGKDYSVTAHSKLVIVTAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPDCKLLIVSNPVDILTYVAWKISGFPKHRVIGSGCNLDSARFRHLMGERLGIHPLSCHGWIVGEHGDSSVPVWSGVNVAGVSLKALHPDMGTDADKEHWKEVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAETIMKNLRRVHPISTAVKGMHGIKDDVFLSVPCVLGSSGITDVVKMILKPDEEEKIKKSADTLWGIQKELQF
Protein: Exocyst complex component 8 (Q7KRZ3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection, growth cone {ECO:0000256|ARBA:ARBA00004624}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
Interaction partners:
- Exocyst complex component 2
- Exocyst complex component 7
- Exocyst complex component 3
- Exocyst complex component 4
- Exocyst complex component 5
- Exocyst complex component 6
- Exocyst complex component 1
- Ras-related protein Ral-a
- Rab11
- LD44762p
Sequence:
MKEFDDFNFSVEKYTKDLTRECVGGSDLQQRKKEIEAYNETTAATLKQTCKKNYMEFIQTAKEISRNLESEMYQLSHILIEQRNILATMTDGKTSSHLKAESLEAESTTATEDLENSHATRAVKEMVQGFNGNLEGKTFLNEGALIELDSNDYRPIQRVFFFLFNDVLIVCKVKHDKRLDFLTEYDPKKIAVINIKDLDGVKNAINIITPDGSKIYQSITAAGKTEWIEKLEEAFRFDQQKKPKKGQAPQPPTRAKQQSKASTPEKETTPQSPGQPKSLEDETPEWLSTASEEIQTLVAQRHFEDAQELIKRTQDFLRNENRKKLPLADAIETKVKQQELKLINVLLKELSNSHNRNLQIALRAAKRPLKILVEMGRYRQASATLLKVCAVSLRVAQREARRNNADISELFFCDLTQVACDFLTAFEKQPACVSALVVWCNAELQYFASQLIKHYLTKGTSLESVAKCVERVRKPSTKLTEIGLDISYHLEGLLRTTLESLIEESKERLLDSVGRTEESWQPYNLQTKSNLKRLLLELDVLGIDVRAQATGDTWINLTQSTVVFIRHFLQLTEYCGCLAKCETLLQSLELLLKELFIAQHSLKPPSDMAVDPNFVMKNKIFLVDNLLPIAIDKFRQISGRQCEGLRELHTKMSRQQGAPVPRQRSVYTTDVF
Protein: Plastin-3 (T-plastin) (Q63598)
Organism: Rattus norvegicus (Rat)
Function: Actin-bundling protein.
Subcellular location: Cytoplasm.
Interaction partners:
- Coronin
Sequence:
MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLMLDGDRNKDGKISFNEFVYIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGETLEELMKLSPEELLLRWANFHLENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPRIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYVDLQDALVILQLYERIKVPVDWSKVNKPPYPKLGANMKKLENCNYAVELGKNQAKFSLVGIGGQDLNDGNPTLTLAVVWQLMRRYTLNVMEDLGEGQKATDDIIVNWVNGTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGCINYDLVKTGNLTEEDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLMGRGMKSV