Protein: Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC) (P45444)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Cytoplasmic dynein intermediate chain
- Nuclear distribution protein nudF
- Dynein light intermediate chain
- Dynein light chain, cytoplasmic
- P150 dynactin NUDM
- Dynein light chain
- Tubulin beta-1 chain
- Tubulin beta-2 chain
- Actin-related protein
- Mitochondrial division protein 1
Sequence:
MEVASSGVPDGAPTAISQGPLVDADAVVEYLADVLRVTLGALRSELENAGSLLSKTKYSETAQRCLRFASESQVALYVQKDLVASDHTNGTADSEEPPAEYVYTLSAEISSSSTTVASVAFIKRPAAIDPSLPISSQIQVMNLPGPAALNNTQAQQGTSLSPYEILHLLVHHGLSPYFEANTRNQDGAAKAKTDSEVKTGVPGTKKKFAELELGLLHLQQNVEIPALNLPLHEVVQAALVEAEKRGVKPSVDLIDSTLLESSAFINSIQNNVNAWIKSIQTITKMSRDADSGSAAQEINFWLSMETALEGIENQLRGDGVQLTMDILRHAKRYQATLSFVADTGLREATDLVQKYNQLMRDFPLDELLSATSLQKVRESLVLIFNHLNKKLKICPYPIKRALALVEAISGDLDSQIHSLLNGRTIMHLDYREFRTLMKTAGSIWRTWDDNLKEFTNVARESTRRRNEKFIPIKINARHDKTQERLKYINTFRVNHEQLQRTIANVLGPKSYSAEDAAAGAAADGAVIVEEIGDVDAVEEVAQAYAALKSVDVLDVSPTGTQNWITAEIAYNERTSRVENSIIARLRDRLATAKNANEMFRVFSKFNALLVRPKIRGAIGEYQTQLIDNVKQDISALHERFKQQYGHSEAHAMAQLRDLPPVSGAIVWARQIERQLDGYMRKVEDVLGEDWHLHTEGQKLQAESNLFRKKLDTRPVFETWLHDVQRRRITISGRLFNIIRNRAAGNTLELAVNFDAQIIALFKEIRNLIWLNFQVPHAVSNISKEAKRVYPYAISLMESVRTLLQTNRSILSMTDVAILLNGYMNDAQSMIVRGIPLRWESFVHSYELHVKQAALVNGALDSVIPSRGESKHVQFVREFAASAAVLQHKTAVLASINDTIQKAIHELKTCPYEFSAFKQRLDAIQAAVDKLNLENYVNLGFWVHNLNQKIEGILSERLHKAIREWMNSFQESQSGQPMQKVNGNGDTDTTAYNIEFPGLTHEISMRNQVLHLDPPLQYARATWFSHFDNWLGIICNLEKIKSSRYQISIEVQKVQLSESCFADLPQHCTNELILVYSAIETRLKEVSEYVDKWLQFQSLWDLQSEQVYDILGDDLSQWLQLLQEIRKSRATFDTSEVSRSFGNIKIDYEQVQTRVNAKYDQWQHEILLKFGSKLGNRMREVHSEIATARHDLEGKSLDSASTAHAVAFITSVQQCKRKAKVWEPEVDLFRQGQATLVRQRYQFPSDWLHVENVDGEWAALNELLGRKGKIVEEQTEALRAKIAAEDKVINDKITEAIAQWNEEKPVSGTIPPEEASRSLSMFQTRLESLQSEFEMVSKAKEALDLPPSAESSLPAILEEVQDFMSVWAALSTIWRSLNDLRDTLWTSIQPRKLRQSIDGLIKMTKEMPSRMRQYAAFEHIQNVLKQLLKVNPLLSDMKSEAVRERHWLKIYKALKPGMRFSLVSLTLGDVWDLQLAASETVIRNIIAQAQGEMALEEFLKSVRETWQNYSLDLVNYQNKCRLIRGFDDLFAKCSENLNSLQAMRHSPYYKEFEEDASSWEDKLNRVHVLFDVWIDVQRQWVYLEGVFTGNADIKHLLPLESSRFQNINSEFFAVMKKVYKSPFVLDVLAINGVQKSLERLAELLNKIQKALGEYLERERVSFPRFYFVGDEDLLEIIGNSNDIFRVAKHFKKMFAGLSGVLMDDDNNIVGFTSKEGEEVRLKKEVNLVKTPRINDWLTALESNMKLTLAELLAEAIEQFEPIYNSAEVDRTAFDDFIANYPAQIVVLASQVVWTNEVQKSLENSGTTLPTLYDAQVRILELLAVTVLGDLDPISRKKCEHLITEFVHQRDTISKLIASNATSATHYLWLLQMRYVYQADGDFLQRLYVHMANAKLNYGFEYLGVPERLVRTPLTDRCFLTLTQALCQRLGGSPYGPAGTGKTESVKALGLQLGRFTLVFCCDDTFDFQAMGRIFLGICQVGAWGCFDEFNRLEERILSAVSQQIQNIQIGLRNKETDEKSQIDLVGRRLTVNMNTGIFITMNPGYAGRSNLPDNLKKLFRSVAMSKPDKELIAEVMLFSQGFKQAKRLSQQTVPFFDHCSTRLSKQAHYDFGLRALKSVLVSSGGLKRARIANSDGDLGPDEIVEPQIIVQSLRETIAPKLVREDVATMLQIQEQDFAGVEYVPANYEALTAAIREIAREQHFVDSEMWITKILQLYQIQSIHHGVMMVGKSGSGKSSAWKILLQALQRIEGVEGVSHIIDSKVMSKEALYGSLDSTTREWTDGLFTGILRKIVDNLRGEDTKRHWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLNLPPNVRIMFEVESLKYATLATVSRCGMVWFNEDTVTPSMIITNYVESLKTKTFEDLDDDSVPSGQSAVKTQDCQDMLSTILSQLLQTDELVHKSLGEAKKYNHIMEFTEIRALNTLFSLLNKACRNILEYNIQHVDFPLEYEQIESYISKKLLLALVWSFTGDCPLGDRKSFGEFVSGLTTIDLPIETNSSIIDFDVTLPKGTWSSWQSQVPTIDVNTHSITQTDVVIPTVDTVRHEDVLYSWLAEHKPLLLCGPPGSGKTMTLFAALRKLPNMEVVGLNFSSATTPDLLIKTFEQYCEYKKTLSGVVMSPNQIGRWLVIFCDEINLPAPDKYGTQRAISFLRQLVEQNGFWRTSDKTWVSLDRIQFVGACNPPTDAGRTPLAERFLRHSPLVMVDYPGEISLNQIYGTFNSAILKILPLLRGYSESLTKAMVQFYLESQQRFTPKIQPHYVYSPRELTRWVRGVYEAIKPLESLSVEGLVRIWAHEALRLFQDRLVTEEERAWTADAVRRIALEHFPTIDQEAALKGPILFSNWLSRNYVPVEQEQLRDFVKARLKTFCEEEVDVPLVLFNDVLEHALRIDRVFRQPQGHLILIGVSGSGKTTLSRFVAWMNGLKVFQIKVHGKYSSEDFDDDLRSVLRRAGCKGEKICFIMDESNVLDSGFLERMNTLLANAEVPGLFEGDEFSSLMTACKEGAQRQGLILDSQEELYKWFTQQIVKNLHVVFTMNPPEEGLSSKAATSPALFNRCVLNWMGDWSDQALFQVGSELTQSVDLDKPGFVAPDSIPVAYRELSLPASHRDTVINAMVYIHHSLQRFNQRLQKQQGKTTYLTPRHYLDFVAQYVKLFNEKREDLEEQQRHLNVGLEKLRDTVEKVSDLRGSLAQKKMQLEKKDAEANEKLQRMVADQREAEQRKAVSLEVQAALEKQEKEVALRKDVVLHDLARAEPAVLEAQKSVSNIKRQHLTEVRSMGNPPAGVRLALEAVCTLLGHKVDSWKTIQGIVRRDDFIASIVNYDNEKQMTKNHRLKMQNEFFSKEDFTYERVNRASKACGPLVQWVEAQVNYSAILDRVGPLRDEVGQLEEQALQTKAEAQAIENTINDLESSIATYKSEYAALISETQAIKAEMERVQFKVDRSVRLLDSLSSERTRWEEGSKSFETQISTLIGDVLIAAAFLAYAGFYDQQFRKAMTEDWVQHLVQSGISLKPHNPITEYLSNADERLAWQAHSLPVDDLSTENAIFLKRYNRYPLIIDPSGRVTEFLQKESSDRKLTVTSFLDDSFVKQLESALRFGNPILIQDAEHLDPILNHVLNKEYQKTGGRVLIQLGKQEIDFSPSFKLFLSTRDPSATFAPDVCSRTTFVNFTITQSSLQIQSLNEVLKSERDDVDRRRSDLVKAQGEFNVHLRQLEKRLLQALNESHGNILDDDNVIETLETLKKEAAEISRKMAETEGVMTEVEEITQRYSIIARSCSAVFAVLEQLHHINHFYQFSLQYFTDIFESVLHGNPHLENSGLRKMEDYQQRIQIILRDLFVTTYQRTSLGVIQKDRITLAMLLAQAAPYPMDKSIIDTILDESVEGTDLSANPEAKVQVMSAFGNMSLFKAHLPSVTAEQWDQFLGEELAENFVPKVWDENTSELDKLLRSLLLVKLCRMDRFVPAAERFIVAVFGRELYEGSTDLKDIVGQVTATAPISLSSSPGFDASYKVDALVERTHATCANIAMGSNEGLESADKAISNAASAGTWVLVKNVHLAPSWLQSLEKRLASLKPHKDFRLFLSMESSPKIPVNLIRASRVLMYEQPAGVRANMKDSLSSLSTRASKAPVEKARVYLLLCFLHAVVQERLRYAPSLGWKGFWEFNDSDYECSANIIDHWVDVVAQGRSNVAPQKLPWDMIRTLITEMYGGKVDDSDDFQQLERLVHSFLTPATFEADYKLVEGVENDECLILPGETGLPAFVEWVNKLPEREPPTYLGLPANAEKLLLVGHGKKMISDLARITSLLDEGEQLMIDA