wanglab/gogpt-training-data huggingface dataset:
Protein: Aquaporin-10 (AQP-10) (Aquaglyceroporin-10) (Small intestine aquaporin) (Q96PS8)
Organism: Homo sapiens (Human)
Function: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH. The channel is permeable to glycerol, especially when the cytosolic pH is acidified. Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation. May contribute to water transport in the intestine (Probable).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:15221416}; Multi-pass membrane protein {ECO:0000269|PubMed:30420639}. Cell membrane {ECO:0000269|PubMed:11573934, ECO:0000269|PubMed:12084581, ECO:0000269|PubMed:23382902, ECO:0000269|PubMed:30420639}; Multi-pass membrane protein {ECO:0000269|PubMed:30420639}. Lipid droplet {ECO:0000269|PubMed:23382902}. Note=Detected around lipid droplets. {ECO:0000269|PubMed:23382902}.
Interaction partners:
- Aquaporin-8
- Lens fiber major intrinsic protein
- Putative aquaporin-12A
- Aquaporin-5
- Aquaporin-11
- Aquaporin-6
- Aquaporin-2
- Aquaporin-9
- Aquaporin-7
- Aquaporin-3
Sequence:
MVFTQAPAEIMGHLRIRSLLARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFLAGSLAVTIAIYVGGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQLLSAFCASGATYVLYHDALQNYTGGNLTVTGPKETASIFATYPAPYLSLNNGFLDQVLGTGMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLSMGANCGIPLNPARDLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGTATYQLLVALHHPEGPEPAQDLVSAQHKASELETPASAQMLECKL
Protein: DDB1 and CUL4 associated factor 11 (H0YL98)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
PDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSVRLQGLRVLAHVWGLDLGGGSTS
Protein: Dynein axonemal assembly factor 5 (HEAT repeat-containing protein 2) (Q86Y56)
Organism: Homo sapiens (Human)
Function: Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23040496, ECO:0000269|PubMed:25232951}. Dynein axonemal particle {ECO:0000269|PubMed:23040496, ECO:0000269|PubMed:25232951}. Note=Observed only in the cytoplasm of ciliated cells and absent from cilia. {ECO:0000269|PubMed:23040496, ECO:0000269|PubMed:25232951}.
Interaction partners:
- Dynein axonemal assembly factor 3
- Zinc finger MYND domain-containing protein 10
- Dynein axonemal assembly factor 11
- Dynein axonemal intermediate chain 2
- Cilia- and flagella-associated protein 298
- Sperm-associated antigen 1
- Dynein axonemal assembly factor 1
- Dynein axonemal assembly factor 19
- Dynein axonemal assembly factor 4
- Dynein axonemal assembly factor 6
Sequence:
MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAEGCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFAAVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQVRRAVASVVGGWLLCLRDRYSFFHKLIPLLLSSLNDEVPEVRQLAASLWEDVGLQWQKENEEDLKDKLDFAPPTPPHYPPHERRPVLGCRELVFRNLSKILPALCHDITDWVVGTRVKSAQLLPVLLLHAEDHATQHLEVVLRTLFQACTDEEAAVVQSCTRSAELVGTFVSPEVFLKLILSTLKKTPSASGLLVLASAMRGCPREALQPHLAAIATELAQAHICQASENDLYLERLLLCVQALVSVCHEDCGVASLQLLDVLLTIVALAGATGLRDKAQETMDSLAMVEGVSSCQDLYRKHIGPLLERVTASHLDWTAHSPELLQFSVIVAQSGPALGEALPHVVPTLRACLQPSQDPQMRLKLFSILSTVLLRATDTINSQGQFPSYLETVTKDILAPNLQWHAGRTAAAIRTAAVSCLWALTSSEVLSAEQIRDVQETLMPQVLTTLEEDSKMTRLISCRIINTFLKTSGGMTDPEKLIRIYPELLKRLDDVSNDVRMAAASTLVTWLQCVKGANAKSYYQSSVQYLYRELLVHLDDPERAIQDAILEVLKEGSGLFPDLLVRETEAVIHKHRSATYCEQLLQHVQAVPATQ
Protein: Mannan polymerase II complex ANP1 subunit (M-Pol II subunit ANP1) (Aminonitrophenyl propanediol resistance protein) (P32629)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the organization of the secretory pathway. Required to maintain a functional Golgi apparatus.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11095735}; Single-pass type II membrane protein {ECO:0000305|PubMed:9434768}. Golgi apparatus membrane {ECO:0000269|PubMed:10713261, ECO:0000269|PubMed:9430634, ECO:0000269|PubMed:9434768}; Single-pass type II membrane protein {ECO:0000305|PubMed:9434768}. Note=Cis-Golgi (PubMed:9430634). Recycles between endoplasmic reticulum and Golgi (PubMed:11095735). {ECO:0000269|PubMed:11095735, ECO:0000269|PubMed:9430634}.
Interaction partners:
- Putative glycosyltransferase HOC1
- Probable alpha-1,6-mannosyltransferase MNN11
- Probable alpha-1,6-mannosyltransferase MNN10
- Mannan polymerase complexes subunit MNN9
- Alpha-1,2-mannosyltransferase MNN2
- Mannan polymerase I complex VAN1 subunit
- Dolichyl-phosphate-mannose--protein mannosyltransferase 2
- Dolichyl-phosphate-mannose--protein mannosyltransferase 1
- Dolichyl-phosphate-mannose--protein mannosyltransferase 5
- Dolichyl-phosphate-mannose--protein mannosyltransferase 3
Sequence:
MKYNNRKLSFNPTTVSIAGTLLTVFFLTRLVLSFFSISLFQLVTFQGIFKPYVPDFKNTPSVEFYDLRNYQGNKDGWQQGDRILFCVPLRDASEHLPMFFNHLNTMTYPHNLIDLSFLVSDSSDNTMGVLLSNLQMAQSQQDKSKRFGNIEIYEKDFGQIIGQSFSDRHGFGAQGPRRKLMARARNWLGSVALKPYHSWVYWRDVDVETIPTTIMEDLMHHDKDVIVPNVWRPLPDWLGNIQPYDLNSWKESEGGLQLADSLDEDAVIVEGYPEYATWRPHLAYMRDPNGNPEDEMELDGIGGVSILAKAKVFRTGSHFPAFSFEKHAETEAFGRLSRRMNYNVIGLPHYVIWHIYEPSSDDLKHMAWMAEEEKRKLEEERIREFYNKIWEIGFEDVRDQWNEERDSILKNIDSTLNNKVTVDWSEEGDGSELVDSKGDFVSPNNQQQQQQQQQQQQQQQQQQQQQQLDGNPQGKPLDDNDKNKKKHPKEVPLDFDPDRN
Protein: GTPase Era (P9WNK9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Exhibits GTPase activity. Binds RNA but is probably not involved in ribosome assembly in mycobacteria (By similarity).
Subcellular location: Cell envelope {ECO:0000255|HAMAP-Rule:MF_00367}. Secreted, cell wall {ECO:0000255|HAMAP-Rule:MF_00367}.
Interaction partners:
- Cytidine deaminase
- Endoribonuclease YbeY
- UPF0053 protein Rv2366c
- GTPase HflX
- Segregation and condensation protein A
- Possible segregation and condensation protein ScpB
- Small ribosomal subunit protein bS16
- PhoH-like protein
- Small ribosomal subunit protein bS6
- Small ribosomal subunit protein uS7
Sequence:
MTEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHAIRGIVHSDDFQIILVDTPGLHRPRTLLGKRLNDLVRETYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTLVVIVTKIDKVPKEKVVAQLVAVSELVTNAAEIVPVSAMTGDRVDLLIDVLAAALPAGPAYYPDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEVSPREGRDDLIDVHAALYVERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF
Protein: Tapasin (TPN) (TPSN) (TAP-associated protein) (TAP-binding protein) (Q9R233)
Organism: Mus musculus (Mouse)
Function: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Beta-2-microglobulin
- Protein disulfide-isomerase A3
- Calreticulin
- Calreticulin
- Calnexin
- Antigen peptide transporter 2
- Antigen peptide transporter 1
- H-2 class I histocompatibility antigen, D-B alpha chain
- H-2 class I histocompatibility antigen, K-B alpha chain
- Proteasome subunit beta type-8
Sequence:
MKPLLLLVAVALGLATVVSVVSAGPEAIECWFVEDAGGGGLSKKPATLLLRHGPRGPPPRPDLDPKLYFKVDDPAGMLLAAFRRYPAGASAPHCEMSRFIPFPASAKWARSLSPEQNCPRALDGDWLLVSVSSTLFSLSSLLRPQPEPLREPVVITMATVVLTVLTHNPAPRVQLGKDAVLDLRFAYAPSALEGSPSLDAGPPPFGLEWRRQHRGKGHLLLAATPGLAGRMPPAQEKATAFAAWDDDEPWGPWTGNGTFWLPAVKPSQEGVYLATVHLPYLQGQVSLELTVHKAPRVSLTPAPVVWAAPGEAPPELLCLASHFFPAEGLEVKWELRGGPGGSSRKVEGKTWLSTIRHHSDGSVSQSGHLQLPPVTAKQHGVHYVCRVYHSSLPASGRSADVTLEVAGFSGPSIEDGIGLFLSAFLLLGLLKVLGWLAAYWTIPEVSKEKATAASLTIPRNSKKSQ
Protein: Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (IL-17 receptor homolog 1) (IL-17ER) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor) (Q9JIP3)
Organism: Mus musculus (Mouse)
Function: Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Interaction partners:
- Interleukin-17B
- Interleukin-25
- Interleukin-17 receptor A
- Interleukin-17 receptor E
- Interleukin-17 receptor D
- Interleukin-17 receptor C
- Interleukin-17C
- Interleukin-33
- Interleukin-17A
- Interleukin-17F
Sequence:
MLLVLLILAASCRSALPREPTIQCGSETGPSPEWMVQHTLTPGDLRDLQVELVKTSVAAEEFSILMNISWILRADASIRLLKATKICVSGKNNMNSYSCVRCNYTEAFQSQTRPSGGKWTFSYVGFPVELSTLYLISAHNIPNANMNEDSPSLSVNFTSPGCLNHVMKYKKQCTEAGSLWDPDITACKKNEKMVEVNFTTNPLGNRYTILIQRDTTLGFSRVLENKLMRTSVAIPVTEESEGAVVQLTPYLHTCGNDCIRREGTVVLCSETSAPIPPDDNRRMLGGWLPLFLVLLVAVWVLAAGIYLTWRQGRSTKTSFPISTMLLPLIKVLVVYPSEICFHHTVCRFTDFLQNYCRSEVILEKWQKKKIAEMGPVQWLTTQKQAADKVVFLLPSDVPTLCDSACGHNEGSARENSQDLFPLAFNLFCSDFSSQTHLHKYLVVYLGGADLKGDYNALSVCPQYHLMKDATAFHTELLKATQSMSVKKRSQACHDSCSPL
Protein: Photosystem II reaction center protein J (PSII-J) (Q2LII9)
Organism: Oryza meyeriana var. granulata
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01305}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01305}.
Interaction partners:
Sequence:
MADTTGRIPLWLIGTVTGIPVIGLIGVFFYGSYSGLGSSL
Protein: Vomeronasal 2, receptor 83 (E9Q0G7)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MLFSCLFFTWLLQMPTLIWTFATSSCLSESEYLLHHDGTVVIGAFFPILKSLPVSETIDWKTLSFDIDNVLEMNVHNYQLVLTMLFAINEINLNSHILPNTSLGLEIYNVPYLQRNALRNVFYWLTGLSTFIPNYSCRKNSKSAATLTGILWKTSENIGTVLDLYKFPQITFGPFDHDQIDRKQFPSLYQVAPKDTSLLSGIASLMLHFNWTWVGLLSTDDHRGAQFLSDLRKVLENNTVCIAFMETVSLWGESLNSLQTHYQMHILESSANVIVIYGSIAFILTVIKNRHSKYITKKVWVMNSKWVGQKFEQYTMLELSHGALSFSHHHGEIFGFTNFVHEATPFKYPEDIFLHVLWNKYFNCSLLQSDCKIIEKCLPNSSLELLPGNIFEMIMTEESYNVYNAVYAVAHSLHEMTLSQMQVQPQAYKDRTMLFPWQLHPFLRNIEVKNSVGDHVVLDWKRKTDTKYDIFNVWNFPTGLSLLVKVGTFAPSAPKEEQFSISEHIIDWPIGFTETPHSVCSESCSPGFRKVVLESKPTCCFDCTPCPDNEISNETGAVQCVKCPETHYANAEKRHCLKKTVTFLDYNDPWGKGLTLMSLGFSALTTLIIGVFVNHRDTPIVKANNRSLTYILLITLALCFLCPLLFIGHPNTVTCIMQQNLFGLLFTVVLSTVLAKTITVVMAFKIAVPGRKLRLLLISQVPNFIIPVCTLIQVCLSGIWLGTFPPFIDMDAHSEYGHIIILCNKGSAIAFYCTLAYLGVMAIGSYLMAFLSRSLPDTFNEAKFLAFSMLVFCAVWVTFLPVYHSTTGKVMVAMEMFSILASSSSLLILIFVPKCYIILFRPERNTVHHIRDERHDRSKNLLKT
Protein: Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Q8BVF7)
Organism: Mus musculus (Mouse)
Function: Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96BI3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96BI3}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q96BI3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96BI3}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000250|UniProtKB:Q96BI3}.
Interaction partners:
- Presenilin-2
- Nicastrin
- Presenilin-1
- Gamma-secretase subunit PEN-2
- Neurogenic locus notch homolog protein 1
- Putative gamma-secretase subunit APH-1C
- Gamma-secretase subunit APH-1B
- Transmembrane emp24 domain-containing protein 10
- Amyloid-beta precursor protein
- Mitochondrial carnitine/acylcarnitine carrier protein
Sequence:
MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLSCRRQEDSRVMVYSALRIPPED
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (CI-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7) (Q9D8B4)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q86Y39}; Multi-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:Q86Y39}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- Acyl carrier protein, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 3
Sequence:
MVKRFFESYHEVPDGTQCHRKTYITTALGGICGIIGSAYRVSLNPADSTLEAVARVGRYTFTAAAIGAMFGLTTCVSAQVREKPDDPLNYFIGGCAGGLTLGARTHSYGTAAMGCVYMGTAAALFKIGKLEGWELFPTPKV
Protein: Uncharacterized protein, isoform C (Uncharacterized protein, isoform D) (A8JR84)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTEFSTNNDHSKPHFTASQQKPHQNSPIHQQAFTPSNPNTHPHLLQRLAQQQQQQQQQQHQRPHKFQQSLPFSQLNNGNNTAAHILPGSSPHSPLSYRNPLNSPSNSPFSNTAQTTIGKRYQQQQLTDRLLQQQHLQQCQQQQLQSLGSSDVEEDLAAEELSEESLKQNVAIVLSNLDRYNNALRSIILNEQVSSSIITPSDSLLFGEDSSGLLYCDNDNSRKHKGNNNFVLGKMAATPESDYNSNATTPGGRSSEQQLQQQQQQQQLGVGGMLCGGGGGGGVGMRETTNGGGNNLNCSLASSHDFTHDNSDYQWFLDYGYRDGCGGMQRSVLSSLSASYNAMGDLIYYEDLAKNLDANLAEVDMESFRAEDIHSLLSHLPAYCKSLGGTNSRLQQSLLLQQQQQQQQQLQQQQVLQHNSMLQHMSQTSTTSTNELIDNSFCKSELLFSPVRESHISVDSLDMDAYPDDGEIILTCNKDNYTIAFEGSVLYSDDSFYADPSDIAARNKQNCINLHSNLEDIVKRNKALEVSMSRSAQAFQPLCPMSPKGQAATTSAAKLQRRSLFLVSPARRYPSGNNNTETITITRHLPQCTVRKSSSLPNLQNEEAMAGSCHKEQGPEESGPQAVPLNVSQAISTSTMEAGKSRSRNLLPMCQMPISISVSISERLQQQADQQLPSEQITPTSQQPQQQHHHSHHHRHKHRCSCSQESHISGSASSGNSSNPPAFNLVKLFIKQKSSNSSGGQEDLGAQASAHTCMDVSSGCWPSSDAASSSSGSLEQRLRKKSMNDSGKGSAVSRHDEEEHYPDTETPRRQLRARSEAVFYDDVASSSSTGSLTATNSPAHRRRSMPLRNPQLYQLAAQVSTGSQMSSEASSEQLTQVPRRAEAGCGTSTRPLSCASSSEMITRSMQTSCGSLSTTRSSLSDRYRCVPPSFLEKLNNLGEERQAPIYVIYPNYALPDLGFVKTNASTDVIFSPFNYKMTMDGATGSTSSSGSLRKQRNSSQSVSEDEILKTLDYKHVADWQSLATLLPSEYRRRLQHIPEVKHLVRQLDAELSQRPLFCMSPPLRRNRTHICDCAKYFQGQQTQTDEASSSGSSQQPSSGYRGSSTLLTDSELDVDPLKQMYVYQYDQQRMDSGVETSPGSQLTQTPPQPMPRSILRKAHSAQSRSKRNSMIEAQQTQKLTKLEKRRSLQEPPNNYGLGSTDELADVFEEEEHSQPAPPVKQRLSRKDLDARARAESFLASLPRSELKYYAEIASILESSGEHVTYDAAALKKEVSRVLSQQKKVSFNDEGVAAGLQQHAKRFATPPNSPNISMGALKRDTVDVLEQRKIESNRFKRLQIQWELMSKDSSMLKELASEAATKSGGSTPTSGNSTGSNSAPRSRIPRPVSYPAGRSSTPTSSRTAPVLATPSPARPATPKTVTKSHNKPGLFTSPRPSRLTSAQEAAGGNKVSTRSPSRIVQPKRYSLAGATTPTSTTPTSARARTPTNRVAVTAPNTPKRQAVAQSPRPTSRVR
Protein: Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase) (PNPase) (O51745)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Function: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01595}.
Interaction partners:
- Small ribosomal subunit protein uS15
- Translation initiation factor IF-2
- Transcription termination/antitermination protein NusA
- Lipoprotein, putative
- DNA-directed RNA polymerase subunit alpha
- Small ribosomal subunit protein uS4
- Ribonuclease Y
- Small ribosomal subunit protein uS11
- Transcription termination factor Rho
- Large ribosomal subunit protein bL17
Sequence:
MKIGRDELVFETGFMAKQANGSVLATYGGSSVLATVCCSSNVREDLDFVPLSVEYNEKYYAAGKIPGGFIKREGKPKDKEILVSRLIDRPMRPLFDKRFGREIQVIPTTLATDQLNPPDIVGMNAAFTAVFLSDIPFNGPIAAVRMVYLNGKFIVNPSFEEIHDSDLDIVVAGSLNGITMVEGGANEVGEDILLSAIDGAHEYIKQICNAQKEFLDIVGKKEKLPLAFEEKIFEFKDELRDFVYADLKEACFVKGKLNRDKAITLLRNKSYEYFSSLEKLTDSNESLFHKAFDDFEKEIVRSSILNDNIRTDGRTPNEIRDIISEVDILSRTHGSALFTRGETQALAVTTLGTSIDEQIMDDIDGDKRLNFMLHYNFPPFSVGETGRLMTGRREIGHGHLAQRALESMVPGKNDFPYTIRVVSEVLESNGSSSMATVCAGSMSLMSAGVPVKGQVAGIAMGLISEGDKYVVLSDILGEEDHLGDMDFKVAGTKNGITGFQMDIKIENVTKDLMRDALEQARIGRIHILSIMNTVISNSRVGISKYAPKIVQLQIDIDKISLVIGSTGKTVKAITDEFEVKVQIEQNGKIILFGDDDFKMQKAKERIESIVREPKVGEIYEGTVKKINSFGAFIELTPAKEGFLSTRLKPRDSKYGSGRFGNSNRYSRFGGGGENIRGNAGLVRPPKLEEGQRIKVKIIDIDKFGKIDLEIVRDKDY
Protein: Neuronal pentraxin chromo domain (F8VQB8)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKQELPARGNISSAPAPAMPTALHSKMDELEGQLLAKVLALEKERAALSHGSHQQRQEVEKELNALQGRVAELEHGSSAYSPPDAFKVSIPIRNNYMYARVRKALPELYAFTACMWLRSRSGGSGQGTPFSYSVPGQANEIVLLEAGLEPMELLINDKVAQLPLSLKDSNWHHICISWTTRDGLWSAYQDGELRGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGMANCTGPLMGNVLPWEDKLVEAFGGAKKAAFDVCKGRAKA
Protein: Anaphase-promoting complex subunit cdc20 (Q54MZ3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mitotic checkpoint protein bub3
- Mitotic spindle assembly checkpoint protein MAD2A
- Probable inactive serine/threonine-protein kinase bub1
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 6
- Probable ubiquitin-conjugating enzyme E2 C
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 1
Sequence:
MNSNYETAELEQLLSLNAPLENVEARWQRKARQNNSNTNNNNGNNGGDRFIPNKMNIDIGHFNLTKENSNPNPNAINNNSSTSTSTTATSSTTNNIESTLYKDTLANQLFESNSGDLESKILSFKSKAPVGNVSSSTNSLRVLYSQNQVGSTPTDQSLKKQFRQIPQQPERILDAPDIVDDYYLNLLDWSSQNVIAIPLGQTVYLWNATTSEIQRLFQVEQQDDYITSLQWTKDGNYLAVGTNSCTIQLWDVAHTKKVRELRGHAGRVGALAWNDYILSSGSSDTNIFNHDVRVQNHHVSTLSGHSQEVCGLKWSHDGGQLASGGNDNIINIWDINSENFETPAHTFEQHTAAVRALAWCPFQPNLLATGGGAADRTIRFWNTITGVCLNTVDTMSQVCSIQWSTTYRELVSSHGYSQNQLCVWKYPSMVKCAELTGHTSRALHTAISPDGETVVSASADETLRFWRVFEKENKLPTANRKSKEVSDGSMMRNINSLIR
Protein: Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8) (Q16322)
Organism: Homo sapiens (Human)
Function: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Voltage-gated potassium channel subunit beta-2
- Voltage-gated potassium channel subunit beta-1
- Potassium voltage-gated channel subfamily A member 1
Sequence:
MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
Protein: Tachykinin-related peptide 1 (TKRP-1) (P86563)
Organism: Banasa dimiata (Banasa stink bug) (Pentatoma dimiata)
Subcellular location: Secreted {ECO:0000269|PubMed:19084564, ECO:0000305}.
Interaction partners:
Sequence:
GPSGFLGMR
Protein: Kinase D-interacting substrate of 220 kDa B (Ankyrin repeat-rich membrane-spanning protein B) (Q7T163)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Downstream target for both neurotrophin and ephrin receptors. May play a role in nerve growth factor (NGF)-induced recruitment of rapgef2 to late endosomes and neurite outgrowth.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q9EQG6}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:22609016}.
Interaction partners:
- Adapter molecule crk
- Putative ATP-dependent RNA helicase DHX57
- Neuron navigator 1
- Transmembrane protein 178A
- LanC-like protein 2
Sequence:
MDTTTSIKMTTLAIQNLFSYVEEENLAAVKVHLDKFKEVDGRSDNGQTPLMLASEQGSLEIVQELIRRGANVNLDDVDCWSALISAAKEGHVEVVKELLENSAYIEHRDMGGWTALTWASYKGRVEVATVLLENGANPNTTGQQYSVYPIIWAAGRGHAEIVKLLLEHGAKVNCSDKYGTTPLIWAARKGHYDCVMHLLENGADVDQEGANSMTALIVAVKGGYTEVVKELLKRNPNVNMTDKDGNTALMIAAKEGYTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLHKYADIDIRGQENKTALYWAVEKGNATMVRDILQCNPDTETTTKDSETPLIKATKMRSIEVVELLLDKGAKVSAVDKRGDTPLHIAIRGRSRRLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTESDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQVEPLFQFSWLVVLLSLLLCGSVALVLGFTVDPKLAIAISLSILALLYVFFVVVYFGSRREGESWNWAWVISTRLARHIGYLELLLKLMFVNPPELPEQTTRALPVRFLFTDYNRLSSVGGETSMAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCIPSFVIFLFILGCLIMGMALLAVFKVDGQNQTVNAVLVSMASVVGLALLLNCRTWWQVTDSVLNSQRKRLHSAANKMHKLKSEGFMKVLKNEVELMAKMAKTIDGFTQNQTRLVVIIDGLDSCEQDKVLQMLDTVRVLFSKGPFISIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSSAKKMCAPAPANGETGNSEGWHEELDRKLSQNSLGDQTKFGSKTTLNRRDTYRRRQMQRSVTRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISFNWDRLASWINLTEQWPYRTSWLILYLEETDGIPDQTNLKTIYERISKNIPTTKDVEPLLEIDGDVRSFEVFLSSRTPVLAARDIRTFLPCTVNLDPKLREIIADVRAAREQVNMAGVTYPTLPLQEGRPISMYSQQSSACSPTASFNGPYNPPGVSPQPHSAYFSGMAGPQHPFYNRGSASVVSGTPSILLSSMSTDVICERVKLIDGIDQNLISQYTATIKKANINGRVLSQCNIDELKKEMNMNFGDWQLFRTSVLEMRHVENQVLHEEAPSEQGSITVGHVEPCRHAGAAAQGVAGNTDTSPMYNFNLSFEELSNVGLEEPPRHVNATWMGTTHRTPSMSSLNSQESSNEICKLTDKQQAEYRNAYEDYIASMSQLELGMEKPVPPFVSQLMHSSSEDKKKDGNDQDGRKSVSKRGSTKSGSDNTDYASADAATLDPITEEDEKVDHGSSKSLLGRKTSGDKVSLFQGADLKLKAGGGSRYQKLTSDDEESEESDNAPLLKDGKKPEAKASDGGDRSLTKGKDYLSDKKDSSDSGVRSNESSPNHSLQDEEADLSQSERANLIELDEENSARKRGLPNSLSGLQDPTIARMSICSEDQCSLLASSPEESWPSSKSYNLNRTPSNTTLNNNTNAQQGNHIRQPSDSSNTTSTTTGSDVIINPGTSTTSATTQNENVRVVHLKRGLNPGDPPEILKVSSETVTFGEERESIL