wanglab/gogpt-training-data huggingface dataset:
Protein: Rhomboid-like protein 20 (AtRBL20) (Q9LET3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mucin
- F3N23.33 protein
- Rhomboid-like protein 17, chloroplastic
- Transmembrane protein
- RHOMBOID-like protein 13
- RHOMBOID-like protein 10, chloroplastic
- Rhomboid-like protein 16, chloroplastic
- Rhomboid-like protein 19
- Rhomboid-like protein 15
- RHOMBOID-like protein 3
Sequence:
MNGGPSGFHNAPVTKAFVITSALFTVFFGIQGRSSKLGLSYQDIFEKFRIWKLIMSTFAFSSTPELMFGLYLLYYFRVFERQIGSNKYSVFILFSGTVSLLLEVILLSLLKDTTANLLTSGPYGLIFASFIPFYLDIPVSTRFRVFGVNFSDKSFIYLAGVQLLLSSWKRSIFPGICGIIAGSLYRLNILGIRKAKFPEFVASFFSRLSFPSFGNSPPPAPSRNIVGTISPNTGRRAERSQPAPLPSSVEPSEEAITTLVSMGFDRNAARQALVHARNDVNAATNILLEAQSH
Protein: TATA-binding protein-associated factor BTAF1 (AtBTAF1) (EC 3.6.4.-) (Protein BTAF1 homolog) (Protein ROOT GROWTH DEFECTIVE 3) (B5BT18)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in meristem development. Acts as positive regulator of the CUC-STM pathway in shoot apical meristem (SAM) neo-formation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- TATA-box-binding protein 2
- TATA-box-binding protein 1
- Histone superfamily protein
- At3g12480/MQC3.32
- Transcription initiation factor TFIID subunit 2
- Protein MIZU-KUSSEI 1
- Protein Dr1 homolog
- AT5g08190/T22D6_130
- At5g23100
- Chromatin modification-related protein EAF1 B
Sequence:
MAQQQSSRLNRLLTLLDTGSTQATRLTAAKQIGDIAKSHPQDLSSLLRKVLHHLRSKKWDTRVAAAHAIGAIVLNVKHPSLSELLNSLATKLGEAGISDNVDEVVAFRNLQSKILANAPFRSFEMNKVLEFGALLASGGQEYDILNDNSKNPRDRVARQKKNLRRRLGLDMCEQFMDVNEMIRDEDLIEQKSNVPANGVGNRLYANCSPHHIQQFVSRMVPRVNSRRPSARELNLLKRKAKISSKDQAKGSCEVADVEMSSSHVASTSKRILSDSLDSSKADIGNEDDIEPDGDGKWPFHSFVEQLILDMFDPAWEIRHGSVMALREILMLHGGSAGVSTEEFSSDNGFELKDVLNKVTREREIDLNMQVSENELEPLRKRPKIEDPSKSFIDNTVLEVIGGDYDINVKDEDAEFLLPPVKVNGQTDCSSTKLEPQSSMDDSTSHSEINHVAEVNNHFEDKSFIEEPVIPKQQEENLEVLDLVKQARHSWIKNFEFLQDCTIRFLCVLSLDRFGDYISDQVVAPVREACAQALGATFKYMNPSLIYETLNILLQMQRRPEWEIRHGSLLGIKYLVAVRQEMLQDLLGYILPACKAGLEDSDDDVRAVAADALIPAAAAIVSLRGQTLLSIVMLLWDILLELDDLSPSTSSIMNLLAEIYSQDDMTLVMHEELSLGEEQNIELNEMGHIESIGERRDVKESPYALSGLAPRLWPFTRHDITSVRFSAIRTLERLLEAGCRKNISGQSKSSFWPSSILGDTLRIVFQNLLLESTEEILECSERVWRLLVQCPVDDLEDTAKFYMASWIELAATPYGSTLDATKMFWPVAPPRKSHFKAAAKMKAVKLENEASSILGFDYARSSASLEKQEDASARSTKIIVGSDMEMSVTRTRVVTASALGIFASRLREGSMQFVVDPLSSTLTSMSGVQRQVGSIVLISWFRETKCKAPSDGSGSLPGFPSPLKKWLLDLLACADPAFPTKDIFLPYAELSRTYTKMRNEASQLLHTVETCHCFDKLLSTNKLNVESVTADETIDFASTLDLWNKESAGNESLEKQVFEDVESSRQQLLSTAGYLKCVQSNLHITVTSLVAAAVVWMSEFPARLNPIILPLMASIKREQEQILQQIAAEALAELIAYCVDRKPSPNDKLIKNICSLTCMDPSETPQASIISSMDIVDDMDFLSSRSNTGKQKAKVVLASGEDRSKVEGFITRRGSELALKHLSLKFGGSLFDKLPKLWECLTEVLVPEIPSDQQKIDLKIESISDPQVLINNIQVVRSIAPVMEETLKPRLLSLLPCIFKCVRHSHVAVRLAASRCVMTMAKSMTTDVMAAVVESAIPMLGDLTCISGRQGAGMLIGLLVQGLGVELVPYSPLLVVPLLRCMSDVDSSVRQSVTRSFAALVPMLPLARGVPPPVGLSKDLSSNAEDAKFLEQLLDNSHIDDYKLCTELKVQLRRYQQEGINWLGFLKRFKLHGILCDDMGLGKTLQASAIVASDAAERRGSTDELDVFPSIIVCPSTLVGHWAFEIEKYIDLSLLSVLQYVGSAQDRVSLREQFNNHNVIITSYDVVRKDVDYLTQFSWNYCILDEGHIIKNAKSKITAAVKQLKAQHRLILSGTPIQNNIMELWSLFDFLMPGFLGTERQFQASYGKPLLAARDPKCSAKDAEAGVLAMEALHKQVMPFLLRRTKEEVLSDLPEKIIQDRYCDLSPVQLKLYEQFSGSSAKQEISSIIKVDGSADSGNADVAPTKASTHVFQALQYLLKLCSHPLLVLGDKVTEPVASDLAAMINGCSDIITELHKVQHSPKLVALQEILEECGIGSDASSSDGTLSVGQHRVLIFAQHKALLDIIEKDLFQAHMKSVTYMRLDGSVVPEKRFEIVKAFNSDPTIDVLLLTTHVGGLGLNLTSADTLVFMEHDWNPMRDHQAMDRAHRLGQKRVVNVHRLIMRGTLEEKVMSLQKFKVSVANTVINAENASMKTMNTDQLLDLFASAETSKKGGGSSKKGSEDNDQIAGTGKGMKAILGNLEELWDQSQYTEEYNLSQFLTKLNG
Protein: GABA-specific permease (GABA-specific transport protein) (P32837)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for high-affinity, high-specificity GABA transport. Also transports putrescine.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:14985124}; Multi-pass membrane protein {ECO:0000269|PubMed:14985124}.
Interaction partners:
- Proline-specific permease
- General amino-acid permease GAP1
- Transcriptional activator protein UGA3
- Glutamate decarboxylase
- 4-aminobutyrate aminotransferase
- Nitrogen regulatory protein DAL80
- Succinate-semialdehyde dehydrogenase [NADP
- Transcriptional activator protein DAL81
- Allantoate permease
- Urea active transporter
Sequence:
MSMSSKNENKISVEQRISTDIGQAYQLQGLGSNLRSIRSKTGAGEVNYIDAAKSVNDNQLLAEIGYKQELKRQFSTLQVFGIAFSIMGLLPSIASVMGGGLGGGPATLVWGWFVAAFFILLVGITMAEHASSIPTAGGLYYWTYYYAPEGYKEIISFIIGCSNSLALAAGVCSIDYGLAEEIAAAVTLTKDGNFEVTSGKLYGIFAGAVVVMCICTCVASGAIARLQTLSIFANLFIIVLLFIALPIGTKHRMGGFNDGDFIFGKYENLSDWNNGWQFCLAGFMPAVWTIGSFDSCVHQSEEAKDAKKSVPIGIISSIAVCWILGWLIIICLMACINPDIDSVLDSKYGFALAQIIYDSLGKKWAIAFMSLIAFCQFLMGASITTAVSRQVWAFSRDNGLPLSKYIKRVDSKYSVPFFAILAACVGSLILGLLCLIDDAATDALFSLAVAGNNLAWSTPTVFRLTSGRDLFRPGPFYLGKIWSPIVAWTGVAFQLFIIILVMFPSQQHGITKSTMNYACVIGPGIWILAGIYYKVYKKKYYHGPATNLSDDDYTEAVGADVIDTIMSKQEP
Protein: Probable prolyl 4-hydroxylase 10 (AtP4H10) (EC 1.14.11.2) (F4JZ24)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in proline-rich peptide sequences of plant glycoproteins and other proteins. Hydroxyprolines are important constituent of many plant cell wall glycoproteins such as extensins, hydroxyproline-rich glycoproteins, lectins and arabinogalactan proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q24JN5}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q24JN5}.
Interaction partners:
- Pyrroline-5-carboxylate reductase
- Proline iminopeptidase
- Proline dehydrogenase 2, mitochondrial
- Proline dehydrogenase 1, mitochondrial
- procollagen-proline 3-dioxygenase
Sequence:
MMARPRNHRPSARKSSHSTLVFAVLIMSTFVILILLAFGILSVPSNNAGSSKANDLTSIVRKTLQRSGEDDSKNERWVEIISWEPRASVYHNFLTKEECKYLIELAKPHMEKSTVVDEKTGKSTDSRVRTSSGTFLARGRDKTIREIEKRISDFTFIPVEHGEGLQVLHYEIGQKYEPHYDYFMDEYNTRNGGQRIATVLMYLSDVEEGGETVFPAAKGNYSAVPWWNELSECGKGGLSVKPKMGDALLFWSMTPDATLDPSSLHGGCAVIKGNKWSSTKWLRVHEYKV
Protein: G patch domain-containing protein 8 (Q9UKJ3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFKPTTVAVDEEGGEDDKDESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEESKSGEATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGDTLESLDSSSQPGPVESSLLPIAPDLEHFPSYAPPSGDPSIESTDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT
Protein: Acyl carrier protein 1, mitochondrial (MtACP-1) (ACP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) (P53665)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of short and medium chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).
Subcellular location: Mitochondrion {ECO:0000305|PubMed:25732537}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 10-A
- NADH dehydrogenase 1 alpha subcomplex subunit 13-A
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 10-B
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 8-B
Sequence:
MALRNAILRHLRVPVQTLGLNQSKIGFLGTIRSFSSHDDHLSREAVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLAIEYVYNHPMSS
Protein: Eukaryotic translation initiation factor 6 (eIF-6) (O62106)
Organism: Caenorhabditis elegans
Function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}. Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-Rule:MF_03132}.
Interaction partners:
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL20
- Probable ribosome biogenesis protein RLP24
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL3
- Nucleolar GTP-binding protein 1
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL4
Sequence:
MALRVDYEGSNDVGVFCTLTNSYCLVGVGGTQNFYSILEAELSDLIPVVHTSIASTRIVGRLTVGNRHGLLVPNATTDQELQHLRNSLPDEVAIRRVDERLSALGNVIACNDHVAIVHAEISAETEQALVEVLKVEVFRVSLAQNSLVGSYCILSSNGCLVAARTPPETQREIAALLQIPVVAGTCNRGSELIGAGMVVNDWVAFCGLDSTSTELSVVESIFKLGEQGAPTSISNQLRDTLIESML
Protein: Serine recombinase PinR (EC 3.1.22.-) (EC 6.5.1.-) (DNA-invertase PinR) (Putative DNA-invertase from lambdoid prophage Rac) (Site-specific recombinase PinR) (P0ADI0)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YnaE
- Prophage tail fiber assembly protein homolog TfaR
- H repeat-associated putative transposase YbfD
- Cold shock protein YdfK
- Prophage tail fiber assembly protein homolog TfaQ
- Serine recombinase PinQ
- H repeat-associated putative transposase YhhI
Sequence:
MSRIFAYCRISTLDQTTENQRREIESAGFKIKPQQIIEEHISGSAATSERPGFNRLLARLKCGDQLIVTKLDRLGCNAMDIRKTVEQLTETGIRVHCLALGGIDLTSPTGKMMMQVISAVAEFERDLLLERTHSGIVRARGAGKRFGRPPVLNEEQKQVVFERIKSGVSISAIAREFKTSRQTILRAKAKLQTPDI
Protein: Tectonic-like complex member MKS1 (Meckel syndrome type 1 protein) (Q9NXB0)
Organism: Homo sapiens (Human)
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000269|PubMed:26490104}.
Interaction partners:
- Coiled-coil and C2 domain-containing protein 2A
- Tectonic-1
- Meckelin
- Centrosomal protein of 290 kDa
- B9 domain-containing protein 1
- Tectonic-2
- Transmembrane protein 216
- Transmembrane protein 231
- Tectonic-3
- B9 domain-containing protein 2
Sequence:
MAETVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAELGKDLIDLATFRPQPTASGHRPEEDEEEEIVIGWQEKLFSQFEVDLYQNETACQSPLDYQYRQEILKLENSGGKKNRRIFTYTDSDRYTNLEEHCQRMTTAASEVPSFLVERMANVRRRRQDRRGMEGGILKSRIVTWEPSEEFVRNNHVINTPLQTMHIMADLGPYKKLGYKKYEHVLCTLKVDSNGVITVKPDFTGLKGPYRIETEGEKQELWKYTIDNVSPHAQPEEEERERRVFKDLYGRHKEYLSSLVGTDFEMTVPGALRLFVNGEVVSAQGYEYDNLYVHFFVELPTAHWSSPAFQQLSGVTQTCTTKSLAMDKVAHFSYPFTFEAFFLHEDESSDALPEWPVLYCEVLSLDFWQRYRVEGYGAVVLPATPGSHTLTVSTWRPVELGTVAELRRFFIGGSLELEDLSYVRIPGSFKGERLSRFGLRTETTGTVTFRLHCLQQSRAFMESSSLQKRMRSVLDRLEGFSQQSSIHNVLEAFRRARRRMQEARESLPQDLVSPSGTLVS
Protein: Cysteine desulfurase SufS (EC 2.8.1.7) (O32164)
Organism: Bacillus subtilis (strain 168)
Function: Type II cysteine desulfurase that acts as the initial step in the SUF-like Fe-S cluster assembly pathway. Catalyzes the removal of elemental sulfur atoms from L-cysteine by using the cofactor pyridoxal 5'-phosphate (PLP), resulting in the production of L-alanine and persulfide. Activity is stimulated by SufU, which acts as a sulfurtransferase that receives sulfur from SufS via a zinc-ligand swapping mechanism and transfers it to SufB.
Interaction partners:
- Zinc-dependent sulfurtransferase SufU
- Iron-sulfur cluster assembly protein SufB
- Vegetative protein 296
- Iron-sulfur cluster assembly protein SufD
- Thioredoxin reductase
- Cystathionine gamma-synthase/O-acetylhomoserine
- Fe-S protein maturation auxiliary factor YitW
Sequence:
MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKYYNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALSYARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVTSNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFFALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTFNLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLVEALQKTKEYFTNVF
Protein: Phosphoenolpyruvate transferase (EC 2.7.8.28) (EPPG:FO PEP transferase) (P9WP81)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
Interaction partners:
- Bifunctional F420 biosynthesis protein FbiB
- Phosphoenolpyruvate guanylyltransferase
- FO synthase
- F420-dependent glucose-6-phosphate dehydrogenase
- Deazaflavin-dependent nitroreductase
- F420-dependent hydroxymycolic acid dehydrogenase
- Large ribosomal subunit protein uL3
- Probable cell division protein WhiA
- Putative F420H
- Probable cytoplasmic peptidase PepQ
Sequence:
MKVTVLAGGVGGARFLLGVQQLLGLGQFAANSAHSDADHQLSAVVNVGDDAWIHGLRVCPDLDTCMYTLGGGVDPQRGWGQRDETWHAMQELVRYGVQPDWFELGDRDLATHLVRTQMLQAGYPLSQITEALCDRWQPGARLLPATDDRCETHVVITDPVDESRKAIHFQEWWVRYRAQVPTHSFAFVGAEKSSAATEAIAALADADIIMLAPSNPVVSIGAILAVPGIRAALREATAPIVGYSPIIGEKPLRGMADTCLSVIGVDSTAAAVGRHYGARCATGILDCWLVHDGDHAEIDGVTVRSVPLLMTDPNATAEMVRAGCDLAGVVA
Protein: Transcription factor Sp1 (Q01714)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. Positively regulates the transcription of the core clock component BMAL1 (By similarity). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O89090}. Cytoplasm {ECO:0000250}. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location (By similarity). {ECO:0000250}.
Interaction partners:
- Estrogen receptor
- Transcription factor Jun
- Histone lysine acetyltransferase CREBBP
- Estrogen receptor beta
- TATA box binding protein
- Cellular tumor antigen p53
- Mitogen-activated protein kinase 3
- Protein c-Fos
- Proto-oncogene tyrosine-protein kinase Src
- cAMP-dependent protein kinase catalytic subunit beta
Sequence:
MSDQDHSMDEVTAVKIEKGVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESGSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTSQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHQLPGLPLAIANTPGDHGAQLGLHGPGGDGIHDETAGGEEGENSPDPQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNGF
Protein: dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (Thymidine diphospho-4-keto-rhamnose 3,5-epimerase) (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase) (dTDP-L-rhamnose synthase) (P9WH11)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage.
Interaction partners:
- Glucose-1-phosphate thymidylyltransferase
- dTDP-4-dehydrorhamnose reductase
- dTDP-glucose 4,6-dehydratase
- Possible dTDP-glucose 4,6-dehydratase
- N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
- UDP-galactopyranose mutase
- Uncharacterized protein Rv1510
- UDP-glucose 6-dehydrogenase
- Probable UDP-glucose 4-epimerase GalE3
- Mannose-1-phosphate guanylyltransferase
Sequence:
MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAFAGHSLDVRQVNCSVSSAGVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVDIREGSPTFGRWDSVLLDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAEYNPQREHTICATDPTLAVDWPLVDGAAPSLSDRDAAAPSFEDVRASGLLPRWEQTQRFIGEMRGT
Protein: Exosome complex component RRP45 (Exosome component 9) (D6RIY6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNLCLQRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEGGGDQAIILDGIKMDTGVEVSDIGSQDAPIILSDSEEEEMIILEPDKNPKKIRTQTTSAKQEKAPSKKPVKRRKKKRAAN
Protein: MutL homolog 3 (H0YJB4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XNSFNKNSKTHSNSNTTENCVISETPLVLPYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARACSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVDVVLENDTVDDTVSSESLQSLFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTRQSLQQSMPPCEPP
Protein: U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3) (Q921Y2)
Organism: Mus musculus (Mouse)
Function: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NV31}.
Interaction partners:
- U3 small nucleolar ribonucleoprotein protein IMP4
- Ubiquitin-like protein FUBI
- KRR1 small subunit processome component homolog
- Periodic tryptophan protein 2 homolog
- Something about silencing protein 10
- U3 small nucleolar ribonucleoprotein protein MPP10
- U3 small nucleolar RNA-associated protein 6 homolog
- WD repeat-containing protein 75
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein uS12
Sequence:
MVRKLKFHEQKLLKQVDFLNWEVTDHNLHELRVLRRYRLQRREEYTRYNQLSRAVRELARRLRDLPERDPFRVRASAALLDKLYAMGLVPTRGSLELCDSVSASSFCRRRLPTLLLKLRMAQHLQAAVAFVEQGHVRVGPDVVTDPAFLVTRSMEDFVTWVDSSKIKRHVLEYNEERDDFDLDA
Protein: Kinesin, putative (Q57ZA7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Kinesin-like protein
- Kinesin, putative
- Kinesin, putative
- Kinesin, putative
Sequence:
MNTSACFTGSSGQSIPGMPQREEGRRRARVVFNDTSPPLVPAMMTHHCSGCSTNDKTIQRSGADGQFASQSVSWGFGSETSKSTRVSATPFTPNGDSESNITVVIRVRPPLPRELKENSRYTDVVRVSKDRSSITLCEPVDLSDNSDDNKASGCFAEVYATQTFTFDYVHDRYDLQRDVYERSARSAVLSVVEGYNATLLAYGQTGAGKTYTMEGFAGEEQHGIIARAVEEIFSIMDDSRCGNVDYTIRASYMQIYNEVISDLLKPPGEEAPRSLVVRHTTRSGVHVDGLSEWNVCSPRDVYYLMERGTSRRATEATRMSELSSRSHAIFILTVETVKKDPVTGSVSSHRVGKLNIVDLAGSEKVRQSGVSGQRLEEARCINKSLHELGNVISALAQRKSCGKDNKDGGASRSSHVPFRNSVLTSVLRDSLGGNCKTTLIVCISPALESHAETLSTLLFANRAKNIRNTAVINEDTQHERQRSLPGQQDAMQLQSQQGLDVGLLSELQQSVRRAEEEREEVVEALQRSLCAHQHEQAVRMQLQRRLEELEAILRDSRGNEAGNGGCEEHVDPEEYMLGLEEIHHQWQVLQEEAMLSRYNELLVKHRDIVVDLTSKLSERDEIIRNLKEELSTRESSEGLTESANDSVPPLVSPGEGVGKSSTALSREEAENCLRRLRVPKPRRDGSGTDMWYRSDTNPSVLLPPDEKILELLTFNHTKIQEVVAPQLDTESRREAAETYVTGGLKDQLAKVVQEAVERIAHQQVSSYFGKLSHAVKDKELQLLALRKDYSTLGRLMDASRAQQLPEALEAISYTRRYFDGQQETVRKAYEGSIEMLRRQLAEKEEKLLHLSGEIDVMRVESQKALEYCTSALQREELSEVCVALKLLQDHVAGEAKRSVERAVECAADACKGETHVGASSNPDTGFKGVELNPASSPEERFASATAVQSLEAQLLDLRSAHSKREEEWRRTLQERDNEISELLTRLNDAKGEDVRGKDAEISFLKRSVEMQKKDRRALQTIMEQRIKPKVDSICKSLEEGIHQQRGEECKRLCTEAQALQGLVSAAVKAMQS
Protein: SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) (P63279)
Organism: Homo sapiens (Human)
Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:16631117, ECO:0000269|PubMed:19744555, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:27068747}. Cytoplasm {ECO:0000269|PubMed:22214662}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12573574}. Note=Mainly nuclear (By similarity). In spermatocytes, localizes in synaptonemal complexes (PubMed:8610150). Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250|UniProtKB:P63280, ECO:0000269|PubMed:8610150}.
Interaction partners:
- Small ubiquitin-related modifier 1
- E3 SUMO-protein ligase RanBP2
- E3 SUMO-protein ligase PIAS1
- SUMO-activating enzyme subunit 1
- Small ubiquitin-related modifier 2
- Ran GTPase-activating protein 1
- SUMO-activating enzyme subunit 2
- Small ubiquitin-related modifier 4
- Importin-13
- E3 SUMO-protein ligase PIAS2
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS