wanglab/gogpt-training-data huggingface dataset:
Protein: Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (C-terminal-linking and modulating protein) (Dietary Pi-regulated RNA-1) (Diphor-1) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) (Q9JJ40)
Organism: Rattus norvegicus (Rat)
Function: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (By similarity). Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts (via PDZ1 domain) directly with KLHL17; the interaction is important for integrity of actin cytoskeleton structures in neurons.
Subcellular location: Membrane {ECO:0000269|PubMed:10829064}; Peripheral membrane protein {ECO:0000269|PubMed:10829064}. Cell membrane {ECO:0000250|UniProtKB:Q9JIL4}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes. {ECO:0000269|PubMed:10829064}.
Interaction partners:
- Sodium-dependent phosphate transport protein 2A
- Sodium/hydrogen exchanger 3
- Cystic fibrosis transmembrane conductance regulator
- A-kinase anchor protein 10, mitochondrial
- Chloride anion exchanger
- Sodium-dependent phosphate transport protein 1
- Scavenger receptor class B member 1
- Ezrin
- PDZK1-interacting protein 1
- cAMP-dependent protein kinase type II-alpha regulatory subunit
Sequence:
MASTFNPRECKLSKKEGQNYGFFLRIEKDTDGHLVRVIEEGSPAEKAGLLDGDRVLRINGVFVDKEEHAQVVDLVRKSGNSVTLLVLDGDSYEKAVKHQVDLKELDQSPREPALNEKKPDLGMNGGVETCAQPRLCYLVKEGNSFGFSLKTIQGKKGVFLTDITPQGVAMKAGVLADDHLIEVNGENVENASHEEVVEKVTKSGSRIMFLLVDKETARCHSEQKTPFKRETASLKLLPHQPRVVVIKKGSNGYGFYLRAGPEQKGQIIKDIEPGSPAEAAGLKNNDLVVAVNGESVEALDHDGVVEMIRNGGDQTTLLVLDKEADRIYSLARFSPLLYCQSQELPNGSVKEAPAPISAPLEAPGSATTEDVGDHKPKLCRLIKEDDSYGFHLNAIRGQPGSFVKEVQQGGPADKAGLENEDIIIEVNGENVQDEPYDRVVERIKSSGEHVTLLVCGKVAYSYFQAKKIPILSSLADPLVAGPDAKGETEHDSAESTKDSSHPARDRTLSAASHSSSNSEDTVM
Protein: Phosphoethanolamine N-methyltransferase 3 (EC 2.1.1.103) (Q9C6B9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes N-methylation of phosphoethanolamine, phosphomonomethylethanolamine and phosphodimethylethanolamine, the three methylation steps required to convert phosphoethanolamine to phosphocholine.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Probable choline kinase 2
- Probable choline kinase 3
- Probable choline kinase 1
- Choline-phosphate cytidylyltransferase 2
- Choline-phosphate cytidylyltransferase 1
- Probable ethanolamine kinase
- Ethanolamine-phosphate cytidylyltransferase
- Phosphoethanolamine N-methyltransferase 2
- Phosphoethanolamine N-methyltransferase 1
- Serine decarboxylase
Sequence:
MASYGEEREIQKNYWKEHSVGLSVEAMMLDSKASDLDKEERPEILAFLPPIEGTTVLEFGAGIGRFTTELAQKAGQVIAVDFIESVIKKNENINGHYKNVKFLCADVTSPNMNFPNESMDLIFSNWLLMYLSDQEVEDLAKKMLQWTKVGGYIFFRESCFHQSGDNKRKYNPTHYREPKFYTKLFKECHMNDEDGNSYELSLVSCKCIGAYVRNKKNQNQICWLWQKVSSDNDRGFQRFLDNVQYKSSGILRYERVFGEGFVSTGGLETTKEFVDMLDLKPGQKVLDVGCGIGGGDFYMAENFDVDVVGIDLSVNMISFALEHAIGLKCSVEFEVADCTKKEYPDNTFDVIYSRDTILHIQDKPALFRRFYKWLKPGGKVLITDYCRSPKTPSPDFAIYIKKRGYDLHDVQAYGQMLRDAGFEEVIAEDRTDQFMKVLKRELDAVEKEKEEFISDFSKEDYEDIIGGWKSKLLRSSSGEQKWGLFIAKRN
Protein: Matrix protein (P11206)
Organism: Newcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)
Function: The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
Subcellular location: Virion {ECO:0000305}.
Interaction partners:
Sequence:
MDSSRTIGLYFDSALPSSNLLAFPIVLQDIGDGKKQIAPQYRIQRLDSWTDSKEDSVFITTYGFIFQVGNEEVTVGMISDNPKHELLSAAMLCLGSVPNVGDLVELARACLTMVVTCKKSATDTERMVFSVVQAPQVLQSCRVVANKYSSVNAVKHVKAPEKIPGSGTLEYKVNFVSLTVVPRKDVYKIPTAALKVSGSSLYNLALNVTIDVEVDPKSPLVKSLSKSDSGYYANLFLHIGLMSTVDKKGKKVTFDKLERKIRRLDLSVGLSDVLGPSVLVKARGARTRLLAPFFSSSGTACYPISNASPQVAKILWSQTARLRSVKVIIQAGTQRAVAVTADHEVTSTKIEKRHTIAKYNPFKK
Protein: Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) (A0A494C0P9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIVSCRFTLRMRSTCNKLILTLTCSSLYFPPIC
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 (Oligosaccharyl transferase subunit MAGT1) (Magnesium transporter protein 1) (MagT1) (Q7ZV50)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Cell surface magnesium transporter.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9H0U3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H0U3}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9H0U3}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
- STT3 oligosaccharyltransferase complex catalytic subunit A.
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
- Oligosaccharyltransferase complex subunit ostc
- Translocon-associated protein subunit gamma
- Magnesium transporter
Sequence:
MLHKLLIVVFLVVCLHDMRLNGQKKKETLLSEKVSQMMEWVSKRAVVRLNGEKFKRLVRAHPRNYSVIVMFTALQPQRQCGVCRQADEEYQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRADTYELQVRGFAAEQLARWVADRTDVHIRVIRPPNYAGPLMLGLLLAFIGSLAYLRRNNLEFLFNKNVWAFSALCFVLIMTSGQMWNHIRGPPYAHKNPNTGQVSYIHGSSQAQFVAETHIVLLFNAAVTIGMVLLHEAATSGLDIVKRKIMCVAGIGLVVLFFSWLLSVFRAKYHGYPYSFLFG
Protein: adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) (Q583C9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- 3', 5'-cyclic nucleotide phosphodiesterase, putative
- Phosphodiesterase
- Phosphodiesterase
Sequence:
MVTFMRELYVRDGAVTYLVFSLLLQVLTASSLANDKIQVKVYNMLYSNKISAKIYDPIIAGFNASITNGNPPSGANVEVVYVPPKNDSDYVGHLNSETSFSNDNNGEELPVILGPVGDKNTLGLLKYFKEKNVISFSPFTGSSKVRSWNPNLYFLTASPAAEMLALLRYAITQLRLHRLGFMYLKDVSYGDDEYKLAVELTTRMDRKLCGVFALKSQIGKESDDSSFSAEWDKFANTRPQGVIVFGSPINDTKKFLMKSLEDERTKGGYLLIPSTLQYVIENKWEKELGRDRFVPDKIIITGTNPLAKDDGYDAIKRFKGDMAKYLKEKKDILSGTGQWNVNLNVDESNFTEQDTEAELMVDGWIAGEVLKQALSCREWLTSRDAFITSLYNQRRYVIDDIVVGDFGGECRGMAGERGASCLCNQGGNVVYMKKMGKDLRLYPMKEGVLALTSSRCYRDLSQLYAPLSGIMFKLTDDPKALRTAEAIYDGAFYVVGKGQLGHSDRFFLHWLSSKSHDTSTALYDEVEKRVVTAVFGVVDDSLLSTKGMAFIDPITLTPQLSNPRRNVIHLSPTLEQQLFVIVEHIIQNGAGKMHAIVRSGDTKDIGEMLNKTLDYFFASLSSFVASGEGSTLRDKLPTAGEVLVAGLISDDIPIILSHLGKHHNVRIFVPFFDVALLYDELVSAFRDKPFADRLLFATNLPHWGDKNTESDLVREFHRVVRDESKWKPLSLLGYVTARAMINVLQRMGHVTPEELVDAIFSQSVITVDDMRYGPFDDKCTNGASFEEKHCAVNYGATHISVWSMSRVLNPSVSPVVTHVTPSMKYDEPKWIRLIYKHIAAVAVSCVVVLALFVTVLVLVIRSSRRNARDNNNAPKEPTDPVTLIFTDIESSTAQWAAHPEQMPDLVATHHRLIRSLITRYECYEVKTVGDSFMIACKSPFAAAQLACDLQRDFLNHDWKTTELDESYREFERKRAEDDSDYTPPTASLDPEVYRQLWNGLRVRVGIHTGLCDIRHDEVTKGYDYYGRTSNMAARTESVGNGGQVLMTRSTYLSLSGKEREQINVTPLGDVPLRGVPKPVEMYQLNAVPGRTFAALRLDREFEEEEDNVTGSITSGSGSPERGLTATAQQVAGCIDALLGTFPATQRQKMLATFCERWRVKKPPGMDAWNEASCRCVTRRIAAKVGCVMDFGTRNTSGSVASFERGGSLFSPGGAAAIMLASSSSSSCVEGRCGTVQLIEQENVSAAS
Protein: Integrin alpha-9 (B8JK39)
Organism: Mus musculus (Mouse)
Function: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Integrin beta-1
- Vascular cell adhesion protein 1
- Osteopontin
- Tenascin
- Tenascin XB
- Fibronectin
- Tenascin-R
- Tenascin-N
- Focal adhesion kinase 1
- Integrin beta-7
Sequence:
MGGPAAARTGAGGLRALLLALVAAGVPAGAYNLDAQRPVRFQGPSGSFFGYAVLEHFHDNTRWVLVGAPKADSKYSTSVKSPGAVFKCRVHTNPDRRCTELDMARGRTRGAPCGKTCRGDRDDEWMGVSLARQPRADGRVLACAHRWKNIYYEADHILPHGFCYLIPSNLQAKGKVLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTLKVLNLTDNTYFKLNDEAIMNRRYTYLGYAVTAGHFSHPSITDVVGGAPQDEGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNMDGLSDLLVGAPMFSEIRDEGQVTVYLNQGHGALEEQLTLTGDAAYNAHFGESIANLGDIDDDGFPDVAVGAPKEEDFAGAVYIYHGDANGIVPKYSMKLSGRRLNPTLRMFGQSISGGIDMDGNGYPDVTIGAFLSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTVCFRFHGKNVPGEIGLNYNLTADVAQKEKGQLPRVYFVLFGETAGQVSERLQLSHMDEVCHHYVAHVKRRVQDVISPIVFEAAYSLDEHVMGEEDRELPDLTPVLRWKKGQRISQKNQTVFERNCQSEDCAADLQLRGKLLLSSVDEKTPHLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEILSFIVTAQSGNLERSEALHDNTLTLTVPLVHEVDTSITGIVSPTSFVYGESVDASNFIQLDDQECHFQPVNITLQVYNMGPSTLPGSSVSISFPSRLSPGGAEMFQVQDMVVSQEKGNCSLQRNPTPCIIPQEQENIFHTIFAFFSKSGRKVLDCEKPGSFCLTLHCNLSALPKEESRTINLYMLLNTEILKKDSSSVIQFMARAKVKVEPALRVVEIANGNPEETLVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDGWDWVQKNQ
Protein: Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1) (O95497)
Organism: Homo sapiens (Human)
Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
Subcellular location: Cell membrane {ECO:0000305|PubMed:11491533}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Pantetheine hydrolase VNN2
- Pantothenate kinase 1
- Pantothenate kinase 2, mitochondrial
- Pantothenate kinase 3
- Glia-derived nexin
Sequence:
MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
Protein: Putative isocitrate lyase subunit A (ICL) (EC 4.1.3.1) (Isocitrase) (Isocitratase) (O07718)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate.
Interaction partners:
- Putative isocitrate lyase subunit B
- Malate synthase G
- Isocitrate lyase
- Aconitate hydratase A
- Uncharacterized FAD-linked oxidoreductase Rv2280
- Probable oxidoreductase
- D-amino-acid oxidase
Sequence:
MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFRPFIIADAGTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRRFTNWASRSSMVIFSMRLATASTRRPAVGLSAKAFSAWSPTRSTRGGRTASSRSTAFSTRSSRGSWRPGRTTRA
Protein: Uncoordinated 115a, isoform B (E1JIH3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Trio, isoform A
- Protein hu-li tai shao
- Netrin receptor unc-5
Sequence:
MYILIYISIPKHPQTDKTRPIYPSTLGTELRTELGKTGQGKQKIYCAKCTKKCSGEVLRVADNHFHKACFQCCQCKKSLATGGFFTKDNAYYCIPDYQRLYGTKCANCQQYVEGEVVSTMGKTYHQKCFTCSKCKQPFKSGSKVTNTGKEVLCEQCVTGAPVSPSRQATGGGVSSPAPPAESPTRATAHQQHGSVISHKAHLKEDYDPNDCAGCGELLKEGQALVALDRQWHVSCFRCKACQAVLNGEYMGKDAVPYCEKCYQKGFGVKCAYCSRFISGKVLQAGDNHHFHPTCARCTKCGDPFGDGEEMYLQGSAIWHPRCGPGPSESGIILNGGGGTSSVVGGASNGNFTDTECDRMSSSALSEMYIRSRTPSFNGSLYSSSRKHYRTVSPGLILREYGRPNAEDISRIYTYSYLTDAPHYLRKPIDPYDKTPLSPHFHRPSSYATTASNAGSVAGSRPPSRPHSRTRSAMKVLVDAIRSETPRPKSPGMNNEEPIELSHYPAAKKPPPGEQPKIERDDFPAPPYPYTDPERRRRYSDTYKGVPASDDEDENVENGKPNGKVKNGEEQQRLQREAEQLEKLNSGIGSAIAKDLKEHAKYRKWKQNNLDPRNASRTPSASKEPLYKLRYESPIGASPSRNLDHQKPFYEDEMFDRSTSYRGSLGKSLGNAPSYNAIHSYRSPPKPGYGFKTTTLPYIRNGFSSDFSYGGLGDKTHSTDLSCGKSEASVDSITEGDRRALMGGDLPASSTYSGALSYHYPQAGLIRRSLPNMSHSMLVHEPAKIYPYHLLLITNYRLPSDVDRCNLERHLSDIEFEHILQCARSEFYRLPQWRRNELKRRVKLF
Protein: Cytochrome P450, family 81, subfamily K, polypeptide 2 (F4KI78)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- WD-40 repeat-containing protein MSI2
Sequence:
MMFFLLLIVYEIDSKRKMENLWVIFLLTATLTFFITKFLWSQNPKLPPSPTPLPIIGHLHLINKYPLPQALHHLSSNYGPVLFLKFGCREVLILSSPDSIEECFTNHDIALANRPKTITSDHFSYGYKNFGFAPYGDLWRTLRRLSTLEVFSSVSLQKNSSIRTEEVSNLCSSLFRFSGGNSCKVDLRYQFTLLTAHVMLRLVSGNRGVNESDSESETKFLDEFKSRFFSSLSSMNVCDYFPVLRWIGYKGLENRVIEIQRMRDEYLQRLIDDIRMKKFDSTGSVVEKFLKLQESEPEFYSDDVIKGIVVLMFNAGSDTSPVTMEWAMALLLNHPDKLDKVREEIKSNVKHKGIIQDSDLSSLPYLRCVIYETLRLHPAAPILPPHCSSKRFNLGNYEIPENTVLLVNAWAVHRDGELWEEADVFKPERFEEFVGDRDGFRFLPFGVGRRACPAAGLAMRVVSLAVGALVQCFEWEKVEKEDIDMRPAFSVAMDRAEPLIALLKPCPEMVPILSQL
Protein: Macrolide export ATP-binding/permease protein MacB (EC 7.6.2.-) (P75831)
Organism: Escherichia coli (strain K12)
Function: Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, the system could also transport R-LPS or a similar glycolipid.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01720, ECO:0000269|PubMed:11544226, ECO:0000269|PubMed:17214741}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01720, ECO:0000269|PubMed:11544226, ECO:0000269|PubMed:17214741}.
Interaction partners:
- Outer membrane protein TolC
- Macrolide export protein MacA
- Multidrug efflux pump subunit AcrA
- Multidrug export protein EmrA
- Lipoprotein-releasing system transmembrane protein LolE
- Lipoprotein-releasing system transmembrane protein LolC
- Probable aminoglycoside efflux pump
- Multidrug export protein AcrF
- Multidrug resistance protein MdtK
- Multidrug export protein EmrB
Sequence:
MTPLLELKDIRRSYPAGDEQVEVLKGISLDIYAGEMVAIVGASGSGKSTLMNILGCLDKATSGTYRVAGQDVATLDADALAQLRREHFGFIFQRYHLLSHLTAEQNVEVPAVYAGLERKQRLLRAQELLQRLGLEDRTEYYPAQLSGGQQQRVSIARALMNGGQVILADEPTGALDSHSGEEVMAILHQLRDRGHTVIIVTHDPQVAAQAERVIEIRDGEIVRNPPAIEKVNVTGGTEPVVNTVSGWRQFVSGFNEALTMAWRALAANKMRTLLTMLGIIIGIASVVSIVVVGDAAKQMVLADIRSIGTNTIDVYPGKDFGDDDPQYQQALKYDDLIAIQKQPWVASATPAVSQNLRLRYNNVDVAASANGVSGDYFNVYGMTFSEGNTFNQEQLNGRAQVVVLDSNTRRQLFPHKADVVGEVILVGNMPARVIGVAEEKQSMFGSSKVLRVWLPYSTMSGRVMGQSWLNSITVRVKEGFDSAEAEQQLTRLLSLRHGKKDFFTWNMDGVLKTVEKTTRTLQLFLTLVAVISLVVGGIGVMNIMLVSVTERTREIGIRMAVGARASDVLQQFLIEAVLVCLVGGALGITLSLLIAFTLQLFLPGWEIGFSPLALLLAFLCSTVTGILFGWLPARNAARLDPVDALARE
Protein: RNA helicase (EC 3.6.4.13) (F4K6V1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAATASAIRYAPEDPNLPKPWKGLVDSRTGYLYFWNPETNVTQYERPASSAPPKLAAIPVSSSVQTNQQSSSGFNSGKEDDKYGRGSDGPKSDSGSRFNEAGRTGPISSNDAASGLGNASSGGSSARGPPSSAAGNELSPEAYCRKHEITVSGGQVPPPLMSFEATGLPNELLRECPNFMPYALSFVPGAIFALGGANVVRCATSLGFLQIIWSALFGGPNFLRCPPAAGFNSYLVLPANGRMVYSAGFSAPSPIQAQSWPIAMQNRDIVAIAKTGSGKTLGYLIPGFMHLQRIHNDSRMGPTILVLSPTRELATQIQVEALKFGKSSKISCACLYGGAPKGPQLKEIERGVDIVVATPGRLNDILEMKRISLHQVSYLVLDEADRMLDMGFEPQIRKIVNEVPTKRQTLMYTATWPKEVRKIAADLLVNPAQVNIGNVDELVANKSITQTIEVLAPMEKHSRLEQILRSQEPGSKIIIFCSTKRMCDQLARNLTRTFGAAAIHGDKSQAERDDVLNQFRSGRTPVLVATDVAARGLDVKDIRVVVNYDFPNGVEDYVHRIGRTGRAGATGLAYTFFGDQDAKHASDLIKILEGANQKVPPQVREMATRGGGGMNKFRRWGTPSSGGGGGRGGYGDSGYGGRGESGYGSRGDSGYGGRGDSGGRGSWAPSRDSGSSGWGRERSRSPERFRGGPPSTSSPPRSFHEAMMMKNR
Protein: Sorcin (A0A8I5Y9M9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
MAAGGGRRAASPTGPGGALRGGSGPTGRAATTQGGGAVCTMSYPGHPGAGGGYYPGGCGGAPGGPVFPGHTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFSEFRELWTVLSGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSGQQGVVNFSYDDATYCF
Protein: Large ribosomal subunit protein uL4m (39S ribosomal protein L4, mitochondrial) (L4mt) (MRP-L4) (Q9BYD3)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Interaction partners:
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein uL2m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL20m
Sequence:
MLQFVRAGARAWLRPTGSQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLELPTGDPQYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIPAVGLNVHSMLKHQTLVLTLPTVAFLEDKLLWQDSRYRPLYPFSLPYSDFPRPLPHATQGPAATPYHC
Protein: Selenoprotein F (15 kDa selenoprotein) (Q923V8)
Organism: Rattus norvegicus (Rat)
Function: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity).
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:11278576}. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
Interaction partners:
- UDP-glucose:glycoprotein glucosyltransferase 1
- Thioredoxin reductase-like selenoprotein T
- Selenoprotein K
- Selenoprotein S
- Selenoprotein M
- Selenoprotein N
- Selenoprotein O
- Selenoprotein H
- Selenoprotein I
- Selenoprotein V
Sequence:
MAAGQGGWLRPALGLRLLLATAFQAVSALGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLPLDPVCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI
Protein: Putative DNA-binding protein (Winged helix-turn-helix transcription repressor DNA-binding protein) (Q67XK8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA binding protein
- Protein kinase superfamily protein
- Zinc finger CCCH domain-containing protein 48
- At4g35700
- ADP-ribosylation factor GTPase-activating protein AGD10
- DEAD-box ATP-dependent RNA helicase 10
Sequence:
MLKSRNPNYSKILICEVCEVLGMGYNFYMRVYEVVDDASTDAIISWSESNNSFIIWNVGEFYRRILPKYVDLGTNLSRFFSNLRSHGFKIVKGRTGVLEFGHEDFIRDKLELMKKMVSDKRKARKAAKSKARKARVQVEFLFQHLQI
Protein: Mind the gap, isoform F (A0A0C4DHA4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNFFVIGFLIMQAASFSLGDELGFPESLGNTESDRRRAISYKNGAPPDLVGVLPSTQQQVNPPVQHPLPEKRISSRSTGAAPYNLQQVQQQQQLQLQQQKLQQQQLQQQLKLKQLLLLQQQQQQQQQLMTEARPLPLGVPAFRPIPQKQLAATQPSAPSSTPAERRVAVDTPEPRVSVNNKLVSSIDQPHSNRTFHVANPVVSQPVAVPVFQAMPQSIARIANVGKEHRTVSSHPNYLQFEEPKFDLKDVTVEELAAAANVTVDTIKHAIYVREQQLKAEHRAQLAAKLREEFMRTSTVRTTTTTTTTTTTTPRPQKSLAEHKVSKVMNAPKEYYPVGYDKNFDDNFKSKVDLPPTSFSCAKQKHFPGLYADTDLGCMVFHVCALTDDGMVRKSFLCPENTLFDQTILKCNWWFYVDCSSSTSVYDSNIPISKSYQLMKSLTYFSKYAGGQRHEQGGDKDENALDIDSLRESMEGVARRQEQAKKAELRVEEQRSMPKEDHEHVVPAEAEQQLSN
Protein: Iron-sulfur cluster transfer protein NUBPL (Nucleotide-binding protein-like) (Q9CWD8)
Organism: Mus musculus (Mouse)
Function: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (By similarity).
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- NADH dehydrogenase complex I, assembly factor 6
- Protein arginine methyltransferase NDUFAF7, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex assembly factor 2
- FAD-dependent oxidoreductase domain-containing protein 1
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
Sequence:
MGTWRRLLLFGGVSLRGGGAATVPPRGCRALGCGRQLLGAESEALKQRRTQIMSRGLPKQKPIEGVREVIVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLRGNPELSPNNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVNVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLAQTLDLDVLGDVPLHLSIREASDMGQPVVFSQPGSDEAKAYLHIASEVVRRLKSSPE
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Q9SK66)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000305|PubMed:25732537}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13-B
- NADH dehydrogenase 1 alpha subcomplex subunit 8-A
- NADH dehydrogenase flavoprotein 2, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 5
- Cytochrome b-c1 complex subunit 9, mitochondrial
- NADH dehydrogenase iron-sulfur protein 6
- NADH dehydrogenase iron-sulfur protein 2
- NADH dehydrogenase 1 beta subcomplex subunit 7
Sequence:
MQVVSRRLVQRPLVGGASIYSSSSLRSLYGVSNHLNGTDNCRYSSSLATKGVGHLARKGTGGRSSVSGIVATVFGATGFLGRYLVQQLAKMGSQVLVPFRGSEDSPRHLKLMGDLGQVVPMKFDPRDEDSIKAVMAKANVVINLIGREYETRNFSFEDANHHIAEKLALVAKEHGGIMRYIQVSCLGASVSSPSRMLRAKAAAEEAVLNALPEATIMRPATMIGTEDRILNPWSMFVKKYGFLPLIGGGTTKFQPVYVVDVAAAIVAALKDDGSSMGKTYELGGPDVFTTHELAEIMYDMIREWPRYVKLPFPIAKAMAAPRDFMVNKVPFPLPSPQIFNLDQINALTTDTLVSDNALKFQDLDLVPHKLKGYPVEFLIQYRKGGPNFGSTVSEKIPTDFYP