wanglab/gogpt-training-data huggingface dataset:
Protein: Polyadenylate-binding protein 6 (PABP-6) (Poly(A)-binding protein 6) (O04319)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Initiation factor eIF-4 gamma, MA3
- Eukaryotic translation initiation factor isoform 4G-2
- Eukaryotic translation initiation factor 2 subunit beta
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor isoform 4G-1
- Polyadenylate-binding protein-interacting protein 3
- Eukaryotic translation initiation factor 6-1
- E3 ubiquitin-protein ligase RMA
- Polyadenylate-binding protein-interacting protein 12
- Eukaryotic translation initiation factor 4B2
Sequence:
MALVKTETQALGNHQHSSRFGSLYVGDLSPDVTEKDLIDKFSLNVPVVSVHLCRNSVTGKSMCYAYINFDSPFSASNAMTRLNHSDLKGKAMRIMWSQRDLAYRRRTRTGFANLYVKNLDSSITSSCLERMFCPFGSILSCKVVEENGQSKGFGFVQFDTEQSAVSARSALHGSMVYGKKLFVAKFINKDERAAMAGNQDSTNVYVKNLIETVTDDCLHTLFSQYGTVSSVVVMRDGMGRSRGFGFVNFCNPENAKKAMESLCGLQLGSKKLFVGKALKKDERREMLKQKFSDNFIAKPNMRWSNLYVKNLSESMNETRLREIFGCYGQIVSAKVMCHENGRSKGFGFVCFSNCEESKQAKRYLNGFLVDGKPIVVRVAERKEDRIKRLQQYFQAQPRQYTQAPSAPSPAQPVLSYVSSSYGCFQPFQVGTSYYYMGNQVPQMSGHQNITTYVPAGKVPLKERRSMHLVYKHPAYPVAKRGAKQTLVFKGEVNRNLEAATCSKATTSEENRKEERRLTLSGKLSPEVKVEESGKQLQ
Protein: Inwardly rectifying potassium channel 1, isoform F (Inwardly rectifying potassium channel 1, isoform G) (A0A0B4KH86)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
Interaction partners:
- ATP-binding cassette sub-family C member Sur
- KCNQ potassium channel, isoform F
Sequence:
MPKMIVDKSELVGENAWAKLLPDEKDKAIIVKMNKSSSNNNDSKETTPLNVDQLVAASNPAVAGEQSAVCLEDTYKRTSTYASNINSTGGESSGSGTQLSRKESILGSFHRQIRRSIKAVSESPGPLTRYRQTRFSSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDVDTPLCSAKQLDELKSEYSKSAKCVNAPFADRTLSASLFQRIASAASVDHLDPASDESLDSGRLQIRSHSIPNGVLASELEPLNNNKHGASFTMGGLTITTTAPSIPNLSSINEKTNSGNSINSSNYSNNNSLSTLTGGGSAASGPGGGITIVAGSGNHGGAGGGGGGGGRHKSNPRRLSIKQDQLPIDSIC
Protein: Protein 4.1 (Band 4.1) (Erythrocyte membrane protein band 4.1) (A0A8I5Y1T6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTEKSLAAEAENSQHQKEEGEGATNSGQQESQLEEASQAAAAEGSNQGEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLLSSFLKRPKSQVSEEEGREVESEREKGEGEQKETELGTSLDEDVILKAPIAAPEPELKTDPSLDLHSLSSIETQPAQEEHREDPDSETKEGEGIEECSGTEVKEDPESRAEREPETSQKPIRRHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAVWDSTTSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTVQSELGDYDPELHGVDYVSDFKLAPNQTRELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTLPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAAESTDRSPRPTSAPAIAQSQVMEGPGAPAKKAPKEAVKVEEKRGEEPAEPEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQVPTGDGSVNGIRTEEVASVTQGPSAYPASERECPKQSVVPSESLMTTPPESPQSFGSGSLSKNSKEAKETEEKEQGAGGHLGAEERPTGPRGECLGVEEQASALSFPVTPASRQLHLGGEKADSSEEPGAPAETPETQSGSFLDSPVGNQFPILTRSFQPPLVKTQTVTISDTANAVKSEIPTKDVPIVHTETKTITYEAAQTEDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEISEE
Protein: Ent-kaurenoic acid oxidase 2 (AtKAO2) (EC 1.14.14.107) (Cytochrome P450 88A4) (Q9C5Y2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes three successive oxidations of ent-kaurenoic acid giving gibberellin 12 (GA12), a key step in gibberellins (GAs) biosynthesis. GAs, which are involved many processes, including stem elongation, play a central role in plant development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11722763}; Single-pass membrane protein {ECO:0000269|PubMed:11722763}.
Interaction partners:
- Gibberellin 20 oxidase 3
- Gibberellin 20 oxidase 2
- Gibberellin 20 oxidase 1
- Ent-kaurene oxidase, chloroplastic
- Gibberellin 20 oxidase 4
- Ent-kaurenoic acid oxidase 1
- Ent-copalyl diphosphate synthase, chloroplastic
- Gibberellin 3-beta-dioxygenase 1
- Gibberellin receptor GID1B
- Gibberellin 2-beta-dioxygenase 8
Sequence:
MTETGLILMWFPLIILGLFVLKWVLKRVNVWIYVSKLGEKKHYLPPGDLGWPVIGNMWSFLRAFKTSDPESFIQSYITRYGRTGIYKAHMFGYPCVLVTTPETCRRVLTDDDAFHIGWPKSTMKLIGRKSFVGISFEEHKRLRRLTSAPVNGPEALSVYIQFIEETVNTDLEKWSKMGEIEFLSHLRKLTFKVIMYIFLSSESEHVMDSLEREYTNLNYGVRAMGINLPGFAYHRALKARKKLVAAFQSIVTNRRNQRKQNISSNRKDMLDNLIDVKDENGRVLDDEEIIDLLLMYLNAGHESSGHLTMWATILMQEHPMILQKAKEEQERIVKKRAPGQKLTLKETREMVYLSQVIDETLRVITFSLTAFREAKSDVQMDGYIIPKGWKVLTWFRNVHLDPEIYPDPKKFDPSRWEGYTPKAGTFLPFGLGSHLCPGNDLAKLEISIFLHHFLLKYRVERSNPGCPVMFLPHNRPKDNCLARITRTMP
Protein: Cell cycle exit and neuronal differentiation protein 1 (BM88 antigen) (Q9JKC6)
Organism: Mus musculus (Mouse)
Function: Involved in neuronal differentiation.
Subcellular location: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MESRGKSASSPKPDTKVPQATAEAKATPAADGKAPLTKPVKKDTQAEKQEQAAAPGPAATKKTPAKADPVLLNNHSNLKPAPTVPAAPSSPDATSEPKGPGDGAEEDESNTGGRGPWPCENLTPLLVAGGVAVATIALILGVAFLARKK
Protein: Cystin-1 (Cilia-associated protein) (Q717R9)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium membrane {ECO:0000269|PubMed:22085962}; Lipid-anchor {ECO:0000269|PubMed:22085962}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:22085962}. Note=Expression is enriched in the ciliary axoneme. Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus.
Interaction partners:
- Protein unc-119 homolog B
- Fibrocystin
- Intraflagellar transport protein 88 homolog
Sequence:
MGSGSSRSSRTLRRRRSPESLPAGPGAAALEGGTRRRVPVAAAEVPGAAAEEAPGRDPSPVAPPDGRDETLRLLDELLAESAAWGPPEPAPRRPARLRPTAVAGSAVCAEQSTEGHPGSGNVSEAPGSGRKKPERPAAISYDHSEEGLMASIEREYCR
Protein: Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) (Q7ZTW4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase TOR
- 3-phosphoinositide-dependent protein kinase 1
- 3-phosphoinositide-dependent protein kinase 1a.
- Serum/glucocorticoid-regulated kinase 2b
- Serine/threonine-protein kinase Sgk1
- RPTOR-independent companion of MTOR, complex 2b.
- Forkhead box protein O1-A
- Forkhead box O3A
- E3 ubiquitin-protein ligase Mdm2
- Target of rapamycin complex subunit lst8
Sequence:
MTIQTETSVSAPDLTYSKTRGLVANLSAFMKQRKMGLNDFIQKLSANSYACKHPEVQSILNLTPPQDVELMNSNPSPPPSPSQQINLGPSSNPTAKPSDFDFLKVIGKGSFGKVLLARHRSDEKFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHYSFQTTDKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIILTDFGLCKENIEPNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNISNAARHLLEGLLQKDRTKRLGFTDDFTEIKNHMFFSPINWDDLNAKKLTPPFNPNVTGPNDLRHFDPEFTDEPVPNSIGCSPDSALVTSSITEATEAFLGFSYAPAMDSYL
Protein: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (PDP 2) (EC 3.1.3.43) (Pyruvate dehydrogenase phosphatase catalytic subunit 2) (PDPC 2) (Q9P2J9)
Organism: Homo sapiens (Human)
Function: Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:O88484}.
Interaction partners:
- Pyruvate dehydrogenase protein X component, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- [Pyruvate dehydrogenase
- [Pyruvate dehydrogenase
- [Pyruvate dehydrogenase
Sequence:
MSSTVSYWILNSTRNSIATLQGGRRLYSRYVSNRNKLKWRLFSRVPPTLNSSPCGGFTLCKAYRHTSTEEDDFHLQLSPEQINEVLRAGETTHKILDLESRVPNSVLRFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTLEHMEGAMESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLRVYWQELLDLHMEMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGATACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREHPESEDRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIYQFTPPHYYTPPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLAQRPANLGLMQSLLLQRKASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLARMYRDDITVTVVYFNSESIGAYYKGG
Protein: Caldesmon 1 (E9QA16)
Organism: Mus musculus (Mouse)
Interaction partners:
- Calmodulin-1
- Myosin-11
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- Leiomodin-1
- Actin, aortic smooth muscle
- Myosin regulatory light polypeptide 9
- Myosin regulatory light chain 12B
- Calmodulin-like protein 3
- Calmodulin-4
Sequence:
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEAHVQNSVPDEESKPASSNTQVEGDEEAALLERLARREERRQKRLQEALERQKEFDPTITDGSLSGPSRRMQNDSAENETAEGEEKRESRSGRYEVEETEVVIKSYQKNSYQDAEDKKKEEKEEEEQEKLKGGSLGENQIKDEKIKKDKEPKEEVKSFLDRKKGFTEVKAQNGEFMTHKLKQTENAFSPSRSGGRASGDKEAEGAPQVEAGKRLEELRRRRGETENEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKAREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSEDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSGVRSTHQAAVVSKIDSRLEQYTNAIEGTKASKPMKPAASDLPVPAEGVRNIKSMWEKGSVFSAPSASGTPNKETAGLKVGVSSRINEWLTKSPDGNKSPAPKPSDLRPGDVSGKRNLWEKQSVDKVTSPTKV
Protein: QRFP-like peptide receptor (C3ZQF9)
Organism: Branchiostoma floridae (Florida lancelet) (Amphioxus)
Function: Receptor for QRFP-like peptide. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25449662}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MMLGNMTFTQTILHELLRQHNMTKNEFIERFGLPPLVYVPELSPGAKTVTLVFYVIIFLAALLGNTLVVVVVWKNKVMRTTMNIFICSLAASDLLITIVCIPVTLMQNMLQNWIMGDFMCKLVPFIQTIAVASSILTLTGIAIERYYAIIHPLKVKYLLSKTRAGIILALVWVVSVGVATPMLFVHKAEEIHDFLYEQRFVTCQEKWWGQTQQTSYTIFNLVVLFIIPLLTMTSLYIRIAHRLWVQQPVGVTGNFAHGNSVRRKRQAVKMLVVVVLLFAVCWLPYHTVTVMNELTGLRLEEKSAKLLIAIVQLIAFSNSFNNPVVYAILNENFKKNFMTMLRCRVNRVSPQQVTPNTLQTPLEQSTRSCRLPAGAPNQQI
Protein: Inhibitor-2 (LD47783p) (Protein phosphatase inhibitor-2) (Q9V3C7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQNNPSPQLPCKGILKTSRSFDKSGASFRKSAKFDELNVMQTFHPADKDYGHMKIDEPKTPYNYTEGFDENRDELDTELLVEKLRIAANTQPSTESIEDDGSSGDDQPLSEEERQRRREFERRRKAHYREFEAVKLARKLIQEEDDDDDDEDKGADSRPSGSSQGASSSGRFASSSTKRSSSQADSTTSPSTSAGQNMDLEPSNN
Protein: Keratin-associated protein 4-1 (Keratin-associated protein 4-10) (Keratin-associated protein 4.1) (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10) (Q9BYQ7)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 3-1
- Keratin-associated protein 4-3
- Keratin-associated protein 4-8
- Keratin-associated protein 4-5
- Keratin-associated protein 9-3
- Keratin-associated protein 3-2
- Keratin-associated protein 9-8
- Keratin-associated protein 2-1
- Keratin-associated protein 9-4
- Keratin-associated protein 17-1
Sequence:
MVNSCCGSVCSDQGCDQGLCQETCCRPSCCQTTCCCPSCVVSSCCRPSCSQTTCCQTTCCRPSCCHPVCCQTTCRPSCGVSSCCRPLCCQTTCHPSCGMSSCCRPLCCQTTCRPSCGVSSCCRPLCCQTTCCRATCCRPSCCGSSC
Protein: Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (Q503E3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR015894}. Nucleus {ECO:0000256|PIRNR:PIRNR015894}.
Interaction partners:
Sequence:
MASGSAGSRVSCGRDLSCVPEVADTLAAVAKLGFDFLCMPLFHPRFRRENELDPAKSRPGAQTRSDLLLCGRDWNTLIVGKLSPWIETDSELTTERRNSEAALVQELNFCAYLGLPAFMIPLRGPHCANLARILLNHIHTGHHSCMFWIRVPLMAPEDTRENLIENEPSKQMDDGSNDEKTWAWWHSFRTLCDYNKRICLAIEIGADLPSDTLIDKWLGEPIKAAILPTSIFLTNKKGFPVLSKAHQRIIFRLFKLEAQFIFTGQNRHSEKDLRSYLQYLEYLNQNRPAPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAVYRCLLDRVPEEQMETNVQVLMVLGAGRGPLVNASLRAAKQAKRKLRVYAVEKNPNAVVTLENWKFEEWGDQVTVVSCDMREWTSPEKADIIVSELLGSFGDNELSPECLDGAQHFLKDDGVSIPCSYTSFLAPLSSSKLYNEVRGCRERDKDPECHFETPYVVRLHNFHQLADPQACFTFVHPTTDMNNNRYQCLRFPVGCNSVLHGFAGYFEATLYKEVTLSIKPETHSPGMFSWFPILFPLKQPIPLSCGDNVCVRFWRCNNGKKVWYEWAVTEPVCSAIHNPAGRSYTIGL
Protein: Canoe, isoform I (A0A0B4KF82)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSHDKKMLDREAVRSVIQQWNANRLDLFALSEPDENLLFHGVMRFYFQDAGQKVATKCIRVASDATVTDVIDTLIEKFRPDMRMLSVPNYALYEVHANGEERRLNADEKPLLVQLNWHIDDREGRFLLKNIDQKTTPIEQTDLNFKRKLSKREKKEQKKKEKMAKLSSDPPTSNGSHLGLGNGVGASSGSAHMNGNAGGTGGDSSDAVAGKLYTELPETSFTRSISNPEAVMRRRRQQKLEKKLQQFRSRDGGPDTGGTLKIYGESLCQDVPYKTLLLSIRDCAQAVVREMLTKYGLEKADPLHYCLVQVNSDGTEYILDDDECPLSILMNHPTSRGSIMFHVRRRPADSQPRRRKKKPLGAANGANHISGDREGPVLVEVTHSGDGGRRIKLGSDPVEVGSANTNCLQLFGPSIQPRHCLISLLEGVCTVTPLHTDALTFVNGHHISQPTILHNGSVVMFGRVASYRFLDSPTDGRYNLALSQSQLDSACLYESRSPTSPGSWNDEDGALSSTHKSDYDHHQQANHSSAYHNNNNNSSDHPLSSTLRDVVDSKAGQDQGANSGNYDGQSLEGNLENETKSISSLKSGGSNSQDRSPKMTGSGILAGGGSGSGDTQGQEPILPAVLEFPETHQELFLRHIISELDVNVPHFKLAPVYSLYLCARYRASTHYRPELQPTERAHKLTMFLHHVANLVYSVVQEQYTDPRILAFWMANSSEFLHFLKSDRHISAFSVQAQEVLAEAVQTAFRNLVNCFRLELSQTLNQFLSENIDHDSAAGLVLTVLGSAMALLRRCRVNAALTIQLFSQLFHYINVICFNTIVANSQMCTGDWGKVMTERLQLLELWAERQGLELAADCHLAKINQCAQFLQAPKSSVEEIQQLACSCFRLNSLQMAALLQQEKLPRNLVDTAIRMAESVADELTRADGREVRLEESPELHLALLLPDDGFSCDVVRGIPTGLVDFLNPLQQQGMCRLAAQPTSIGLWTVYMHQFNARSSSAMSNKLPQPELQLIKLHKNSNGMGLSIVAAKGAGQEKLGIYIKSVVPGGAADADGRLQAGDQLLRVDGQSLIGITQERAADYLVRTGPVVSLEVAKQGAIYHGLATLLQQPSPVIQREASPSNFLQHLNTGQQRRHSSFQQQARYYNNSISDDSLNRSRRESFACMRASSPPVRRLSASCLQEELCALGHQLHIDPRYRDTRPIARSASNLYLGNDQGGYYHPPPMAPCVTHFSPMRPLRKTPPPSIYIEEYHDEPAKDSQESFGNFAAYSDAHQPLNEEGIASMALSDEIPFIDDEEEEKQHQQRPCMSTSSCSSTVKRNPAAGYRKTVSFDLEQGDGEPGAIGIDRKYHTHDAISHFAASASSTESLMADKDERIPLIQKIRRELNSKRATNCSADGFSSGGSGSNSQRSSSESIERMPLLRQNHSPCQRQLNTQRSHKRSGVGTAAPIVSIQVPSVCEIESSSTRSPTVNTSNRYCASTTFQTKTIPSTTMKANSRRASSQVNLNPRFLLPLGQGKVREMAEYFNANKNFPPIINKSRSTSALDDPGSNPCAKLSQAEQSRILKQLKEWSLHGSAGKDFDEAEKVGDKISCECPCCAHCRGKREQHQGKQEQHQVAATFKCYDSCRDVEAEPTKQKPELSRYTSYRQSVMCSNRQAHSVRQLKRNKQQKHVQLRTKPSSHSRHHHHHHCHKQQRPRAPATPPSTDNTKSNSSDTKRSSASMRNPQSCSNCGDAIDDCHSCSCSEVESCSSAGESSSSCCAAHCEVLETCGHSRRGDNDSNAGGGIDGNHGGGGHCVKMSLPVSTETTSTTVFPTHR
Protein: Tyrosine-protein phosphatase (EC 3.1.3.48) (Q8WSF2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000927}.
Interaction partners:
Sequence:
MFERFRLNNLTRTFRLRGGGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYNYLEPTLSDWSYTGLTCTATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTSGCVPLETALSQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKISRSSAAINDDED
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (M9PDA8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDDFGSTASDLEEATCPMQANATFSIDWRVTLLDHWLDLYLGYMNRLHMLLSLAGRLHLLSRHILGTLGQDPIFMGVLQGSLLMLFLFLMHLLRLWSCGYAVERPLNPTPDVAKELSCDFNFVSEQEKRAAQEAATEALLEVEEKKRRKRFTKKRNCVSAGPILIALRHQSKRPKHHRHAALPFEPVTPGEIILDTYLPPRELPLTIRLPQLAEPVKEEEVEYIELKSEPRGTLSTTDEIYPDSSDSSLYVSDEEQEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDEDAESDTLGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPSEGPIPENQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWLEQEEFV
Protein: Small COPII coat GTPase SAR1A (EC 3.6.5.2) (O04834)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in transport from the endoplasmic reticulum to the Golgi apparatus.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NR31}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NR31}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9NR31}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NR31}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9NR31}. Note=Active at endoplasmic reticulum exit sites (ERES) where it inserts into the membrane and recruits the remainder of the coat protein complex II/COPII. {ECO:0000250|UniProtKB:Q9NR31}.
Interaction partners:
- SEC12-like protein 2
- SEC12-like protein 1
- SEC12-like protein
- Protein transport protein SEC13 homolog B
- Protein transport protein SEC31 homolog B
- Protein transport protein SEC31 homolog A
- Protein transport protein SEC23 D
- Protein transport protein SEC24 A
- ER membrane protein complex subunit 3
- Protein transport protein SEC13 homolog A
Sequence:
MFMIDWFYGVLASLGLWQKEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSEELSIGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYDKERFAESKKELDALLSDESLASVPFLILGNKIDIPYAASEDELRYHLGLSNFTTGKGKVNLTDSNVRPLEVFMCSIVRKMGYGEGFKWVSQYIK
Protein: T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) (Q8N103)
Organism: Homo sapiens (Human)
Function: May function as a GTPase-activating protein and may play important roles during T-cell activation.
Interaction partners:
- Radial spoke head protein 3 homolog
- SH2B adapter protein 3
- Regulator of G-protein signaling 1
- Bridge-like lipid transfer protein family member 1
Sequence:
MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSWPFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQSLSFEAQKDLNNKVKTLVEFLIDNCFEIFGENIPVHSSITSDDSLEHTDSSDVSTLQNDSAYDSNDPDVESNSSSGISSPSRQPQVPMATAAGLDSAGPQDAREVSPEPIVSTVARLKSSLAQPDRRYSEPSMPSSQECLESRVTNQTLTKSEGDFPVPRVGSRLESEEAEDPFPEEVFPAVQGKTKRPVDLKIKNLAPGSVLPRALVLKAFSSSSLDASSDSSPVASPSSPKRNFFSRHQSFTTKTEKGKPSREIKKHSMSFTFAPHKKVLTKNLSAGSGKSQDFTRDHVPRGVRKESQLAGRIVQENGCETHNQTARGFCLRPHALSVDDVFQGADWERPGSPPSYEEAMQGPAARLVASESQTVGSMTVGSMRARMLEAHCLLPPLPPAHHVEDSRHRGSKEPLPGHGLSPLPERWKQSRTVHASGDSLGHVSGPGRPELLPLRTVSESVQRNKRDCLVRRCSQPVFEADQFQYAKESYI
Protein: Transcription factor Sox-10 (SRY (sex determining region Y)-box 10) (Q8AXX8)
Organism: Xenopus laevis (African clawed frog)
Function: Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox9 to induce neural crest progenitors. Acts downstream of wnt-signaling at the neural plate border. Involved in the specification of neural crest progenitors fated to form the pigment cell lineage.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P56693}. Nucleus {ECO:0000250|UniProtKB:P56693}.
Interaction partners:
Sequence:
MSDDQSLSEVEMSPVGSEDPSLTPDPLPPHAHSSPDDDDDDDEEEEEETKVKKEQDSEDERFPVCIREAVSQVLNGYDWTLVPMPVRVNGGSKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNENDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKPSPGEGDGSSEAEGGAASIQAHYKNSHLDHRHGSPMSDGNSEHSTGQSHGPPTPPTTPKTELQAGKSDGKRDGSHALREGGKPQIDFGNVDIGEISHDVMSNMETFDVNEFDQYLPPNGHAGHPSHIGGYTSSYGLTGALAAGPSAWALAKQHSQTVADSKAQVKTESSSTSHYTEQPSTSQLTYTSLGLPHYGSAFPSISRPQFDYADHQPSSSYYSHSAQASSLYSAFSYMGPPQRPLYTAISDPPSVAQSHSPTHWEQPVYTTLSRP
Protein: TLC domain-containing 3Ba (Zgc:73225) (Q6PBV7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MASSAGYIIACSCKDIIEDQHWLTTSYILFAVPYFVYDIYAMFLCYWYKLQVKDHEEESETKPMRSAIRGYLHREFLMVLHHVVMVTVCFPVSVFWRQGKGDYFQGVMFLAELSTPSVCLGKILIQYKQQHTLLHKVNGALMLVTFFICRVVLFPYLYYAYGRYASIPFYMVPLSVPWQCNVGAALLMAPQVYWFSLICRGAFRLFTGASRHKAPISNTDSEPKSSLLPPANGYSPRETDSH
Protein: Dro3 protein (Q2UYC0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MVQMKFLFAILAVMTIVLMEANTVSARDCLSGTFGGPCWAWSGEKCRRLCIEEGHVSGHCSGGMKCWCEGC
Protein: Casparian strip membrane protein 5 (AtCASP5) (Q9LXF3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates membrane-cell wall junctions and localized cell wall deposition. Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21593871}; Multi-pass membrane protein {ECO:0000269|PubMed:21593871}. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain.
Interaction partners:
- CASP-like protein 4C1
- Mechanosensitive ion channel protein 4
- F3H9.20 protein
Sequence:
MKSGQAEIMETSKGIQKSGLMSRRIAILEFILRIVAFFNTIGSAILMGTTHETLPFFTQFIRFQAEYNDLPALTFFVVANAVVSGYLILSLTLAFVHIVKRKTQNTRILLIILDVAMLGLLTSGASSAAAIVYLAHNGNNKTNWFAICQQFNSFCERISGSLIGSFIAIVLLILLILLSAIALSRRH
Protein: Protein rer1 (Retention of ER proteins 1) (Q10358)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Surfeit locus protein 4 homolog
- ER lumen protein-retaining receptor
- Probable coatomer subunit beta'
- Probable coatomer subunit epsilon
- Probable coatomer subunit zeta
- Membrane glycoprotein spo14
Sequence:
MEFIQRHIENVKEKKNFAVRLYRHWVDRTIPYTTYRWLTVSGLIALFFIRILLVRGWYIVCYTLAIYLLNLFLAFLTPKFDPSVEQAMKDEEIEEGVLPTSKDDEFRPFIRRLPEFKFWYSSMRATLFALVASFFRIFDVPVFWPILVVYYLVLSFFCFRRQIQHMLKYRYVPFDIGKKKFGSH