wanglab/gogpt-training-data huggingface dataset:
Protein: Tubulin-specific chaperone A (B5G0E8)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|RuleBase:RU364030}.
Interaction partners:
Sequence:
MMIPDCQRRLEVAHAELTQLLENEKELEEAEEYKEARSILESVKLEA
Protein: Solute carrier family 13 member 4 (Na(+)/sulfate cotransporter SUT-1) (NaS2) (Q9UKG4)
Organism: Homo sapiens (Human)
Function: Sodium:sulfate symporter that mediates sulfate reabsorption in the high endothelial venules (HEV).
Subcellular location: Membrane; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sulfate transporter
- 26S proteasome non-ATPase regulatory subunit 9
- Proteasomal ATPase-associated factor 1
- Chloride anion exchanger
- 26S proteasome regulatory subunit 10B
Sequence:
MGLLQGLLRVRKLLLVVCVPLLLLPLPVLHPSSEASCAYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELVSAEDEQLVAGNSNTEEAEPISLDVKNSQPSLELIFVNEESNADLTTLMHNENLNGVPSITNPIKTANQHQGKKQHPSQEKPQVLTPSPRKQKLNRKYRSHHDQMICKCLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQYPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGCNFKETCSLSKKKKTKREQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPGFVPGWDSFFEKKGYRTDATVSVFLGFLLFLIPAKKPCFGKKNDGENQEHSLGTEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLFHLDTYPAWARVSNITDQA
Protein: Photosystem II reaction center protein T (PSII-T) (P0C427)
Organism: Oryza sativa (Rice)
Function: Seems to play a role in the dimerization of PSII.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00808}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00808}.
Interaction partners:
Sequence:
MEALVYTFLLVSTLGIIFFAIFFREPPKVPTKKVK
Protein: MHC class II antigen beta chain (Q5K595)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSMSIFCVSLTLVLSIFSGTDGYFFQVVRQCRYSSKDLQGIEFIHSYVFNQAENIRFNSTVGKYVGYTELGVKNAEAWNKGPELAGELGKLERFCKHNADLHYSTILDKTVEPHVRLSSVAPPSGRHPAMLMCSAYDFYPKPIRVTWLRDGREVKSDVTSTEELANGDWYYQILSHLEYTPRSGEKISCMVEHISLTEPMVYHWDPSLPEAERNKIAIGASGLVLGAILALAGLIYYKKKSSGVL
Protein: Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein) (Q9Y6N9)
Organism: Homo sapiens (Human)
Function: Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:20142502}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19297620, ECO:0000269|PubMed:21709241}. Cell projection, microvillus {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:32209652}. Note=Colocalizes with F-actin (By similarity). Detected at the tip of cochlear hair cell stereocilia (By similarity). Enriched in microvilli of the intestinal brush border (PubMed:24725409, PubMed:32209652). {ECO:0000250|UniProtKB:Q9ES64, ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:32209652}.
Interaction partners:
Sequence:
MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF
Protein: Zinc finger CCHC domain-containing protein 17 (Nucleolar protein of 40 kDa) (pNO40) (Pnn-interacting nucleolar protein) (Putative S1 RNA-binding domain protein) (PS1D protein) (Q9NP64)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12893261}.
Interaction partners:
- Pinin
- Nuclear cap-binding protein subunit 2
Sequence:
MNSGRPETMENLPALYTIFQGEVAMVTDYGAFIKIPGCRKQGLVHRTHMSSCRVDKPSEIVDVGDKVWVKLIGREMKNDRIKVSLSMKVVNQGTGKDLDPNNVIIEQEERRRRSFQDYTGQKITLEAVLNTTCKKCGCKGHFAKDCFMQPGGTKYSLIPDEEEEKEEAKSAEFEKPDPTRNPSRKRKKEKKKKKHRDRKSSDSDSSDSESDTGKRARHTSKDSKAAKKKKKKKKHKKKHKE
Protein: Pumilio homolog 3 (APUM-3) (AtPUM3) (Q9ZW02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Binds the APUM-binding elements (APBEs) in the 3'-UTR mRNA sequence of CLV1, PNH, WUS and FAS2.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Non-phototropic hypocotyl-like protein
- Zinc finger CCCH domain-containing protein 42
- Zinc finger CCCH domain-containing protein 5
- At1g73390
- SAGA-associated factor 29 homolog B
- Importin subunit alpha-3
Sequence:
MMIPELGRRPMHRGNEDSSFGDDYEKEIGVLLGEQQRRQVEADELERELNLYRSGSAPPTVDGSLSAAGGLFSGGGGASFLEFGGVNKGNGFGGDDEEFRKDPAYLSYYYANMKLNPRLPPPLMSREDLRVAQRLKGSNNVLGGVGDRRKVNDSRSLFSMPPGFEAGKPGASASEWDANGLIGLGLGGKQKSFADIFQADMGHPVVQQPSRPASRNTFDENVDSNNNLSPSASQGIGAPSPYCYAAVLGSSLSRNGTPDPQGIARVPSPCLTPIGSGRVSSNDKRNTSNQSPFNGVTSGLNESSDLVNALSGLNLSGTGGLDERGQAEQDVEKVRNYMFGLQDGHNEVNPHGFPNRSDQARGTASCRNSQMRGSQGSAYNSGSGVANPYQHHDSPNYYALNPAVASMMANQLGTNNYSPMYENASATLGYSAMDSRLHGGSFVSSGQNLSESRNIGRVGNRMMEGGTGHPSHLADPMYHQYARFSENADSFDLLNDPSMDRNYGNSYMNMLEIQRAYLGSQKSQYGLPYKSGSPNSHSYYGSPTFGSNMSYPGSPLAHHGMPNSLMSPYSPMRRGEVNMRYPAATRNYTGGVMGSWHMDASLDEGFGSSMLEEFKSNKTRGFELSEIAGHVVEFSSDQYGSRFIQQKLETATTDEKNMVYEEIMPKALALMTDVFGNYVIQKFFEHGLPPQRRELGEKLIDNVLPLSLQMYGCRVIQKAIEVVDLDQKIQMVKELDGHVMRCVRDQNGNHVVQKCIECVPEENIEFIISTFFGHVVTLSTHPYGCRVIQRVLEHCHNPDTQSKVMEEILSTVSMLTQDQYGNYVVQHVLEHGKPDERTVIIKELAGKIVQMSQQKFASNVVEKCLTFGGPEERELLVNEMLGTTDENEPLQAMMKDQFANYVVQKVLETCDDQQRELILTRIKVHLNALKKYTYGKHIVARVEKLVAAGERRMALQSLPQPLVA
Protein: ADP-ribosylation factor-like protein 2 (P36404)
Organism: Homo sapiens (Human)
Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Also regulates mitochondrial integrity and function.
Subcellular location: Mitochondrion intermembrane space {ECO:0000305|PubMed:30945270}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. {ECO:0000250|UniProtKB:O08697}.
Interaction partners:
- ADP-ribosylation factor-like protein 2-binding protein
- Protein unc-119 homolog A
- Tubulin-specific chaperone D
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
- Tubulin beta-2A chain
- Tubulin beta-4B chain
- Tubulin beta-4A chain
- Tubulin beta-2B chain
Sequence:
MGLLTILKKMKQKERELRLLMLGLDNAGKTTILKKFNGEDIDTISPTLGFNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDLPGALSSNAIREVLELDSIRSHHWCIQGCSAVTGENLLPGIDWLLDDISSRIFTAD
Protein: Stress response protein ish1 (Q9Y7X6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in maintaining cell viability during stationary phase induced by stress response. Activated by the spc1 MAPK pathway.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:11751918}.
Interaction partners:
- Heat shock protein hsp9
- Glutathione-independent glyoxalase hsp3101
- Charged multivesicular body protein 7
- Meiotically up-regulated gene 190 protein
- SDO1-like protein C21C3.19
- Reticulon-like protein 1
Sequence:
MRSRSVASLGVLLAIVFYIFTYGFSTYRKNDTSAVKTWLEEHSIPYGSRSSPSDFQQFISESYDSLVPNLDKWSGHNLNSWLGKKTESSYLDAISNKIRKTGRKLSGSVEDARDATQEAWESQKASLFESWSDSQLRAFLARHSPQFAAKEKKGILEKLSPASLRETAAKEYDALTSKLGNTGDWIYDTWSDNELRTWLHDVGVPISSHESTRSHLLRKLKNYISTKADEAQPSVEAVKGKASEKAKQAGEFVSDKAGDAKELVNEKSSEAGQYAGQKMEEGGELLQEISKRRGRFGNWWANSGLKAYFDAHGIPAYQPSPIDQFYAHLRRQYYLKTNGYQALKSKAYEEASNVADSASSIASNVASGATEAYQGAASGASRFTEGAKTAAESVTSAFEHNKDTATSKAKQMKGKAASLGSTASEKVGEAADYAAETASKVASKAASKVRETIDETIIERWQDSKLKEFLFLRGVPVPQRSTKDQLLDLVRKHFNKGAVPNWAAYFDTLSSKELSAWIKEYKKHYHGKLHPSKDREHLFQNACNIYRAIAEKADKSVLQSIQSKFPKATVPGYDSWSNEDLKSALKEYGDSIGKVFNRKDAIERLKRHDILFYGPVVADKAKSGVSGFLRRVASFMGFGTRDVAEIKLGENIQKVKDTASKASSAVSSAGDYVETNVKKAQRVL
Protein: Retinoic acid receptor, gamma, variant a (E7BBH7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MFDCMEALGMGPRQLYDVTSRGTCMLRKASPFFAGLDPFAWTGSASVQSVETQSTSSEEMVPSSPSPPPPPRIYKPCFVCQDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCQINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKDVKEELVPPESYELSGELEELVNKVSKAHQDTFPSLLQLGKYHTNSSAEQRVQLDLGLWDKFSELSTKCIIKIVEFAKRLPGFTTLTIADQITLLKSACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAISLISGDRMDLEEPQKVDKLQEPLLEALKIYARRRRPNKPHMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEAFEDQTESSGESSPPPAPPPIPPASSKPPTTMKTEAEDEEDSWGTEPSPEEEDEDDYDDGEEEDRDRGSDSEGESWALEGSSEGARKNHAGRAQ
Protein: GTP diphosphokinase CRSH1, chloroplastic (EC 2.7.6.5) (Calcium-activated RelA/Spot homolog 1) (OsCRSH1) (ppGpp synthetase CRSH1) (Q6ATB4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Possesses calcium-dependent ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase activity in vitro and is able to functionally complement E.coli relA mutants. May be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:17938177}.
Interaction partners:
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase 1
- Inosine triphosphate pyrophosphatase
- Probable monofunctional riboflavin biosynthesis protein RIBA 3
- Probable bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic
- Probable bifunctional riboflavin biosynthesis protein RIBA 2, chloroplastic
- Molybdenum cofactor biosynthesis protein 1
- Os04g0662700 protein
- Putative GTP diphosphokinase RSH1, chloroplastic
- Nucleoside diphosphate kinase
Sequence:
MATAATTSAAAIPTGGGGRRQHPHPRRPGLRPRRLHRLRLPAQAAAAAAASSPSTSSSSSSSSTPAEGGGRLVAELVGAFNELTGRMGEGLATSSSSRLLFRALKLALPALRDGDGGRALARALAIAASLADLQMDAEVISAGILREALDAGAISMRDVKSEIGISTAHLLHESLRLKHAPSKLDVLDDESASALRKFCLSYYDIRAVILELALKLDMMRHLDCLPRYLQRIKSLEVLKIYAPLAHAVGAGNLSLELEDLSFRYLFPHSYDHIDQWLRSQETENKLLIDSYKEQLLQALKDDDELSQIVQDISIQGRYKSRFSTMKKLVKDGRKPEEVNDILALRVILEPRCDGSSLDWGPRACHRTHEIIQAMWKEVPGRTKNYVTRPKENGYQSLHVAIDVSEPGKMRPLMEIQIRTKEMHKFAVGGEASHSLYKGGLTDPGEAKRLKAIMLAAAELAAMRLRDLPASDQGDSNCTNRAFCQLDKNGDGRISIEELTEVMEDLGAGGKDAKELMHLLDANSDGSLSSDEFEAFQRQIELMRSLDDKDDRYRKILKEKLQTIDSAGLIQVYRKQLGDKLLVS
Protein: Elongation of fatty acids protein (EC 2.3.1.-) (Q4QFR8)
Organism: Leishmania major
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Putative fatty-acid desaturase
- Putative stearic acid desaturase
- Fatty acid elongase 6
- Polyprenol reductase
- Elongation of fatty acids protein
- very-long-chain
- Uncharacterized protein
- beta-ketoacyl-[acyl-carrier-protein] synthase I
- Delta-12 fatty acid desaturase
Sequence:
MEALDNYLIDHYDGHAVQKWLVNNVDIGVYIAAAYLTFVFKGPQLVDFIFRGNPPTRLIKMCWTLWNIGLALFSMYGVYHTVPLFINNLRKYGQKDTLCRFRDDEFYTGKNGVAMGLFSLSKLPEFGDTFFLIMGGKRKLPFLSWFHHVTIFLYAWMAYQQASSIWIVLASINYFVHSIMYTYFALAEAGFKKLVKPFAMYITLLQITQMVVGLYFTFSFISYHKADPKGCNGSTMALARGQCMIYFFNFYLFSEMFIKGYVLPRKAAAGESAAATAPASKKRN
Protein: Uncharacterized protein (Q381S8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRALSGLFLPLRLLAPIQTRNIHGSRIIRRDYTDDEGDDEKLTKDRLIHSLGFESDNMDNLLHDITTGEKPIESSRQREHGRKQMSRVAEICMKEEMFSQVLKQLAAAHKGVVVEVPGGGERDVPAISEEDDTLHELINRLGLQVEKHTRIEKVDDLPEVRVQHAVLTLLGRALQQSLNGFRRECNKRFKARSAGKESEDVGHLLAWRCKVLKAYAECFASLTEVHHHFSNTVGDKNTGDNENASDVCTECLSSAAIISSGLSATVELRWHLSNCLKVAGAEDETLTSLDHSIMSCSSRLLTDASALLEETVSKGVRGTGGSAQPSLLHSVLLLAERTLGTLETTRGAACKDLSGSVNAFYSMMLCVLFSFTSFPPGATFQLESRCITTLRQLWAKIAPPLERRTSDSLMTHRTVHSTLNLRYLRCREGLHADNKFLQFLSSKPDSAFLVLELLNRVAAVWATRNEARDYDLIPAVNSSAVLCRTLLEMEIELYFLACSKTAKNWIVLVDPSTKKEGATQAQPPSESAWERVLVAASTVRVGVSSLIELYVRSYVSQDLQGPPPSNPRTKMAFTKHPACCFLKNISASFFPLLRRHYLDTLGSEVLVSCLQVFLLLKQLSDVMESGGGGDDRQSGQVAEALRVCGVPLSQAAEVAFFMSFLQYGCHVRPVSSSGISADSVVSPTIVSMYVREVLFALDYNTAKQLRHLRAKKVLHCFTGLRCDNGEKVDGRLLRRQAQSVLSVVHAHVMHPSFLWMPLHQLQEIFFILSHERQLTKGLRNTKGALGDEASETPSLFSVGSHGAKPRHFSRALGYLSLRLYVVTNVLRHYRIFLLRGDRRKGVGMPLNDSAVEERKRMRRQWSRDMAHLLHSKCSNLLAEVEGLNPANSTDQEKANWRALARLEATINLAVRNSLIYSVKKRKRMAALDAARERGEAEASVEAGDNTSPEDIGAEPSDGEGTADHKAPAERVFHLTLMRNDAEAPLGFSLHGSRSTIRRIVFKNDGVMGGASVAGNNTPFSAALREIGILDPHSVVGWRITQIDGTDVEDTSAIIPLIRGKRKFSMTLRPGDDNKS
Protein: Down syndrome cell adhesion molecule 1, isoform AB (Q0E9J4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVNQYYEAEVVSEYVIRGNTAVLKCTIPSFVADFLRVEAWVASDGTEYAPEEDFDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVGPKISVGERLRDAGAPSKSTLTLFCPAQSYPVPSFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMAPPKITPFSFGEEPANVEDSVSVTCLISTGDLPIDIEWFFNEYGISSYSGISVMKGGKRNSVLSIDSVQARHAGNYSCRAKNHAAAVNYTTDLIVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQQANGAGFTAYDTMAV
Protein: Transmembrane 6 superfamily member 1 (Q9BZW5)
Organism: Homo sapiens (Human)
Function: May function as sterol isomerase.
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:P58749}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Hyaluronan and proteoglycan link protein 4
Sequence:
MSASAATGVFVLSLSAIPVTYVFNHLAAQHDSWTIVGVAALILFLVALLARVLVKRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHMICYWDGSAHYLMYLVMVAAIAWEETYRTIGLYWVGSIIMSVVVFVPGNIVGKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPSENYNYPSKVIQEAQAKDLLRRPFDLMLVVCLLLATGFCLFRGLIALDCPSELCRLYTQFQEPYLKDPAAYPKIQMLAYMFYSVPYFVTALYGLVVPGCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEAKILFLALNIAYGVLPQLLAYRCIYKPEFFIKTKAEEKVE
Protein: LD32019p (Q8MQJ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
LDSNGQCSQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTASSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVNQLQPRDLCPRFQAPRNGKSHCNRYRHKQKLFYYSRCRISCNSGYILQGPEIKSCDANGIWEGPETKCVAINQPRAQSPGICPALKPAQNGVILPASCTQGPSRFGDVCRLQCNAGFVSTGSLLTACMMLQGWSFGADLNCQPFGNGLLGNQLSPMWNSPKTVTPHQIQNVEQIRPYINCPENVVILLHAGEQKAHVTLQRPQTNVKNGRLVAHPAWAGQLQGHLPAGVHKVDFRVNDPETKLTIKCHTIITVKAATPRESNPFTLFRISDYSRSSLPRPAPFATLSTGSSFSFPAFKALDATPKPVSFTKFQVFPDSESSEHSKLGSSSFFRLEPLFHESSKLISAAPASSENTRVDLGSDTSNYCPPSIEVYLKENQNLRSVVWDEPRFEGKLLKIYKSHFPGSLFKVGDHAIKYEATTTDGKTLSCTFFIYVRSAKPTPAPTEPKISFDSEPETLSDVSQTYVVCPDKEPVRVTAESVSLPVGCTLKNIRPKSRSPKELKRGKLTSLWHQYTNF
Protein: Probable acyl-activating enzyme 5, peroxisomal (EC 6.2.1.-) (AMP-binding protein 5) (AtAMPBP5) (Q9FFE6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs.
Subcellular location: Peroxisome {ECO:0000305}.
Interaction partners:
- Protein DETOXIFICATION 29
- Putative acyl-activating enzyme 19
- Lon protease homolog 2, peroxisomal
Sequence:
MEQMKPCAANSPPLTPIGFLERAATVYGDCTSIVYGSNTVYTWRETNLRCLRVASSLSSIGIGRSDVVSVLSPNTPAMYELQFAVPMSGAILNNINTRLDARTVSVLLRHCGSKLLFVDVFSVDLAVEAISMMTTDPPILVFIADKEEEGGDADVADRTKFSYTYDDLIHRGDLDFKWIRPESEWDPVVLNYTSGTTSAPKGVVHCHRGIFVMSIDSLIDWTVPKNPVYLWTLPIFHANGWSYPWGIAAVGGTNVCLRKFDAPLIYRLIRDHGVTHMCGAPVVLNMLSATNEFQPLNRPVNILTAGAPPPAAVLLRAESIGFVISHGYGLTETAGLNVSCAWKPQWNRLPASDRARLKARQGVRTVGFTEIDVVDPESGRSVERNGETVGEIVMRGSSIMLGYLKDPVGTEKALKNGWFYTGDVGVIHSDGYLEIKDRSKDIIITGGENVSSVEVETVLYTNPAVNEVAVVARPDVFWGETPCAFVSLKSGLTQRPTEVEMIEYCRKKMPKYMVPKTVSFVDELPKTSTGKVMKFVLREIAKKMGTTRLSRM
Protein: IQ motif containing GTPase activating protein 1 (G3V7Q7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Cell division control protein 42 homolog
- Catenin beta-1
- Cadherin-1
- CAP-Gly domain-containing linker protein 1
- Mitogen-activated protein kinase 3
- small monomeric GTPase
- CD44 antigen
- Dual specificity mitogen-activated protein kinase kinase 1
- Actin, cytoplasmic 1
- Ras-related C3 botulinum toxin substrate 1
Sequence:
MSAAEEVDGLGVVRPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKIELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDHRVAADTFTALKNPNAMLVNLEEALAPTYQDVLYQAKQDKMTNAKNRTENSDRERDVYEELLTQAEIQGNVNKVNTSSALANINLALEQGCALTLLKALQSVALGLRGLQTQNSDWYLKQLQSDLQQKRQSGQTDPLQKEEVQAGVDAANGAAQQYQRRLAAVAAINAAIQKGIAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQQQSPEHSLTHPELTVAVEMLSSVALINRALESGDMNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFVTWNDIQACVDHVNLVVHEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLPEVAQHYQDTLIRAKREKAQETQDESAVLWLDEIQGGIWQSNKDTQEAQRFALGIFAINEAVESGDVGRTLSALRSPDVGLYGVIPECGETYQSDLAEAKKKRLAAGDNNSKWVKHWVKGGYHYYHNLETQAGGWAEPPDFVQNSVQLSREEIQSSISGVTAAYNREQLWLANEGLITKLQACCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLHSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMIVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFQTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALSHEEVKTRLDNSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAAEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQAACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESCGNSNDPSKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATNEQEAEHQRAMQRRAIRDAKTPDKMKKSKPMKEDNNLSLQEKKEKIQTGLKKLTELGTVDPKNRYQELINDIAKDIRNQRRYRQRRKAELVKLQQTYSALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQANQFKNVIFEIGPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
Protein: Transmembrane protein 88 (Q9D0N8)
Organism: Mus musculus (Mouse)
Function: Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein.
Interaction partners:
- Segment polarity protein dishevelled homolog DVL-1
Sequence:
MAEVPGAQRPVLAGGPEPRDPLDCWACAVLVTAQNLLVAVFNLLLLALVLGTILLPAVIMLGFGFLCHSQFLRSQAPLCTSHLRDPGFTALLVTGFLLLVPLLVLALATYRRLCLRLRLADCLVPYSRALYRRRRIPQPKQIPVSPGSRSVPTPGKVWV
Protein: IkappaB kinase (EC 2.7.11.10) (A0A499FJS7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
Protein: Large ribosomal subunit protein uL30 (60S ribosomal protein L7) (P14148)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}.
Interaction partners:
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL21
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein eS26
Sequence:
MEAVPEKKKKVATVPGTLKKKVPAGPKTLKKKVPAVPETLKKKRRNFAELKVKRLRKKFALKTLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNSLIARSLGKFGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN