wanglab/gogpt-training-data huggingface dataset:
Protein: 4-hydroxymandelate oxidase (EC 1.1.3.46) (O52792)
Organism: Amycolatopsis orientalis (Nocardia orientalis)
Function: Catalyzes the oxidation of p-hydroxymandelate to p-hydroxybenzoylformate in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, 2 non-proteinogenic amino acids occurring in the vancomycin group of antibiotics.
Interaction partners:
- 4-hydroxymandelate synthase
- (S)-3,5-dihydroxyphenylglycine transaminase (p-hydroxyphenylglycine transaminase)
- 4-hydroxyphenylpyruvate dioxygenase
- Aminotransferase
- L-lactate permease
Sequence:
MTYVSLADLERAARDVLPGEIFDFLAGGSGTEASLVANRTALERVFVIPRMLRDLTDVTTEIDIFGRRAALPMAVAPVAYQRLFHPEGELAVARAARDAGVPYTICTLSSVSLEEIAAVGGRPWFQLYWLRDEKRSLDLVRRAEDAGCEAIVFTVDVPWMGRRLRDMRNGFALPEWVTAANFDAGTAAHRRTQGVSAVADHTAREFAPATWESVEAVRAHTDLPVVLKGILAVEDARRAVDAGAGGIVVSNHGGRQLDGAVPGIEMLGEIVAAVSGGCEVLVDGGIRSGGDVLKATALGASAVLVGRPVMWALAAAGQDGVRQLLELLAEEVRDAMGLAGCESVGAARRLNTKLGVV
Protein: Golgi apyrase (EC 3.6.1.5) (ATP-diphosphatase) (ATP-diphosphohydrolase) (Adenosine diphosphatase) (ADPase) (Golgi nucleoside diphosphatase) (Yeast nucleoside diphosphatase 1) (P40009)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:10409709, ECO:0000269|PubMed:14562095}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uridylate kinase
- CTP synthase 2
- CTP synthase 1
- Ribonucleoside-diphosphate reductase small chain 1
- Ribonucleoside-diphosphate reductase large chain 2
- Ribonucleoside-diphosphate reductase large chain 1
- Ribonucleoside-diphosphate reductase small chain 2
- Inosine triphosphate pyrophosphatase
- Bifunctional purine biosynthesis protein ADE17
- Bifunctional purine biosynthesis protein ADE16
Sequence:
MLIENTNDRFGIVIDAGSSGSRIHVFKWQDTESLLHATNQDSQSILQSVPHIHQEKDWTFKLNPGLSSFEKKPQDAYKSHIKPLLDFAKNIIPESHWSSCPVFIQATAGMRLLPQDIQSSILDGLCQGLKHPAEFLVEDCSAQIQVIDGETEGLYGWLGLNYLYGHFNDYNPEVSDHFTFGFMDMGGASTQIAFAPHDSGEIARHRDDIATIFLRSVNGDLQKWDVFVSTWLGFGANQARRRYLAQLINTLPENTNDYENDDFSTRNLNDPCMPRGSSTDFEFKDTIFHIAGSGNYEQCTKSIYPLLLKNMPCDDEPCLFNGVHAPRIDFANDKFIGTSEYWYTANDVFKLGGEYNFDKFSKSLREFCNSNWTQILANSDKGVYNSIPENFLKDACFKGNWVLNILHEGFDMPRIDVDAENVNDRPLFQSVEKVEERELSWTLGRILLYASGSILAGNDDFMVGIAPSERRTKLTGKKFIPGKLLESDQLRKQSSSLSNKGFLMWFAIICCIFYLIFHRSHIIRRRFSGLYNITKDFKTGIRRRLKFLRRSDPFSRLEEGELGTDVDGFKDVYRMKSSSMFDLGKSSATMQREHEPQRTASQSANLAPSNLRPAFSMADFSKFKDSRLYD
Protein: DUF636 domain protein (AFU_orthologue AFUA_2G15290) (Q5AVT6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Isocitrate dehydrogenase subunit 1, mitochondrial
Sequence:
MPLTGHCLCGAVTYKAEVDQPLITAYDHCDDCQRQTGSTYSLVAVVPKDTLTINGPTKSFAKNGSSGKAVHRIFCSECGSPIAHDPEAAPPIIALKAGTLDTEIKKNLKPDTEIWTVGKLPFCQEHLEKPFEHMPQ
Protein: Candida glabrata strain CBS138 chromosome G complete sequence (Q6FSZ2)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome E complete sequence
- Candida glabrata strain CBS138 chromosome H complete sequence
- Candida glabrata strain CBS138 chromosome A complete sequence
Sequence:
MRFPLPLESQLSPFDYHQVRDKFGFKTPLFALTHFESQTMSSLSGMRGLEENGISTGIAKGYKSTPHVRSWGFLSFLHGVISC
Protein: Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain] (Q9ESD1)
Organism: Mus musculus (Mouse)
Function: Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates (By similarity). Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Prostasin]: Secreted, extracellular space {ECO:0000250}.; SUBCELLULAR LOCATION: [Prostasin light chain]: Secreted, extracellular space {ECO:0000250}. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus. {ECO:0000250}.; SUBCELLULAR LOCATION: [Prostasin heavy chain]: Secreted, extracellular space {ECO:0000250}. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus. {ECO:0000250}.
Interaction partners:
- Kunitz-type protease inhibitor 1
- Epithelial sodium channel subunit beta
- Kunitz-type protease inhibitor 2
- Epithelial sodium channel subunit alpha
- Epithelial sodium channel subunit gamma
Sequence:
MAPRVGLGLGQLEAVTILLLLGLLQSGIRADGTEASCGAVIQPRITGGGSAKPGQWPWQVSITYDGNHVCGGSLVSNKWVVSAAHCFPREHSREAYEVKLGAHQLDSYSNDTVVHTVAQIITHSSYREEGSQGDIAFIRLSSPVTFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLQTPRPLQQLEVPLISRETCSCLYNINAVPEEPHTIQQDMLCAGYVKGGKDACQGDSGGPLSCPMEGIWYLAGIVSWGDACGAPNRPGVYTLTSTYASWIHHHVAELQPRVVPQTQESQPDGHLCNHHPVFSSAAAPKLLRPVLFLPLGLTLGLLSLWLEH
Protein: Galectin-3-binding protein (Basement membrane autoantigen p105) (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (MAC2BP) (Mac-2 BP) (Tumor-associated antigen 90K) (Q08380)
Organism: Homo sapiens (Human)
Function: Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Subcellular location: Secreted {ECO:0000269|PubMed:8390986}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9501082}.
Interaction partners:
- Galectin-3
- Fibronectin
- Galectin-7
- Galectin-1
- Soluble calcium-activated nucleotidase 1
- CD209 antigen
- Tubulin gamma-1 chain
- CD9 antigen
- Mitotic-spindle organizing protein 2A
- Gamma-tubulin complex component 3
Sequence:
MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQGYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFPMMLPEELFELQFNLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTSPTWSAFVTDSSWSARKSQLVYQSRRGPLVKYSSDYFQAPSDYRYYPYQSFQTPQHPSFLFQDKRVSWSLVYLPTIQSCWNYGFSCSSDELPVLGLTKSGGSDRTIAYENKALMLCEGLFVADVTDFEGWKAAIPSALDTNSSKSTSSFPCPAGHFNGFRTVIRPFYLTNSSGVD
Protein: Photosystem II 22 kDa protein 1, chloroplastic (22 kDa protein of photosystem II 1) (Photosystem II subunit 1) (OsPsbS1) (Q943K1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in high light-mediated energy-dependent nonphotochemical quenching (NPQ, qE) and thermal dissipation (TD) thus regulating energy conversion in photosystem II and protecting from photoinhibition. Seems also to regulate quantum yield of electron transport in fluctuating light conditions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250|UniProtKB:Q9XF91}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Photosystem II 22 kDa protein 2, chloroplastic
- Photosystem I reaction center subunit N
- Chlorophyll a-b binding protein
- Chlorophyll a-b binding protein
- Glyceraldehyde-3-phosphate dehydrogenase
- Photosystem I reaction center subunit V, chloroplastic
- Chlorophyll a-b binding protein
- Chlorophyll a-b binding protein
- Photosystem I reaction center subunit psaK, chloroplastic
- Os08g0119800 protein
Sequence:
MAQSMLVSGANGTVAAASTSRLQPVRPTPFSRLVLSQPSSSLGRAVSVKTVALFGRSKTKAAPARKAEPKPKFKTEDGIFGTSGGIGFTKENELFVGRVAMLGFAASILGEAITGKGILAQLNLETGIPIYEAEPLLLFFILFTLLGAIGALGDRGSFVDDQPVTGLDKAVIAPGKGFRSALGLSEGGPLFGFTKANELFVGRLAQLGIAFSIIGEIITGKGALAQLNIETGVPINEIEPLVLFNVVFFFIAAINPGTGKFVSDDDEE
Protein: Sugar transporter SWEET1 (HsSWEET1) (RAG1-activating protein 1) (Solute carrier family 50 member 1) (Stromal cell protein) (Q9BRV3)
Organism: Homo sapiens (Human)
Function: Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:21107422}; Multi-pass membrane protein {ECO:0000269|PubMed:21107422}. Cell membrane {ECO:0000269|PubMed:21107422}; Multi-pass membrane protein {ECO:0000269|PubMed:21107422}. Note=May also localize to the endoplasmic reticulum. {ECO:0000250}.
Interaction partners:
Sequence:
MEAGGFLDSLIYGACVVFTLGMFSAGLSDLRHMRMTRSVDNVQFLPFLTTEVNNLGWLSYGALKGDGILIVVNTVGAALQTLYILAYLHYCPRKRVVLLQTATLLGVLLLGYGYFWLLVPNPEARLQQLGLFCSVFTISMYLSPLADLAKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFIRFWLFWKYPQEQDRNYWLLQT
Protein: Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) (O94916)
Organism: Homo sapiens (Human)
Function: Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:10377394}. Cytoplasm {ECO:0000250|UniProtKB:Q9WV30}. Chromosome {ECO:0000269|PubMed:34049076}. Note=Nuclear distribution increases under hypertonic conditions (By similarity). Recruited to sites of R-loop-associated DNA damage following poly-ADP-ribosylation by PARP1 (PubMed:34049076). {ECO:0000250|UniProtKB:Q9WV30, ECO:0000269|PubMed:34049076}.
Interaction partners:
- Sodium- and chloride-dependent betaine transporter
- Protein c-Fos
- Sodium/myo-inositol cotransporter
- Aldo-keto reductase family 1 member B1
- Vascular endothelial growth factor C
- Signal transducer and activator of transcription 3
Sequence:
MPSDFISLLSADLDLESPKSLYSRESVYDLLPKELQLPPSRETSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTSNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLENQKGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPAAAGALNVNVKKEISSPARPCSFEEAMKAMKTTGCNLDKVNIIPNALMTPLIPSSMIKSEDVTPMEVTAEKRSSTIFKTTKSVGSTQQTLENISNIAGNGSFSSPSSSHLPSENEKQQQIQPKAYNPETLTTIQTQDISQPGTFPAVSASSQLPNSDALLQQATQFQTRETQSREILQSDGTVVNLSQLTEASQQQQQSPLQEQAQTLQQQISSNIFPSPNSVSQLQNTIQQLQAGSFTGSTASGSSGSVDLVQQVLEAQQQLSSVLFSAPDGNENVQEQLSADIFQQVSQIQSGVSPGMFSSTEPTVHTRPDNLLPGRAESVHPQSENTLSNQQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSTASANGNLQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPAVSGNETSTTTTQQVATPGTTMFQTSSSGDGEETGTQAKQIQNSVFQTMVQMQHSGDNQPQVNLFSSTKSMMSVQNSGTQQQGNGLFQQGNEMMSLQSGNFLQQSSHSQAQLFHPQNPIADAQNLSQETQGSLFHSPNPIVHSQTSTTSSEQMQPPMFHSQSTIAVLQGSSVPQDQQSTNIFLSQSPMNNLQTNTVAQEAFFAAPNSISPLQSTSNSEQQAAFQQQAPISHIQTPMLSQEQAQPPQQGLFQPQVALGSLPPNPMPQSQQGTMFQSQHSIVAMQSNSPSQEQQQQQQQQQQQQQQQQQSILFSNQNTMATMASPKQPPPNMIFNPNQNPMANQEQQNQSIFHQQSNMAPMNQEQQPMQFQSQSTVSSLQNPGPTQSESSQTPLFHSSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSINQQDMQQSPLYSPQNNMPGIQGATSSPQPQATLFHNTAGGTMNQLQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAISQPGQPQNEGQPPVTTLLSQQMPENSPLASSINTNQNIEKIDLLVSLQNQGNNLTGSF
Protein: 60S ribosomal export protein NMD3 (hNMD3) (Q96D46)
Organism: Homo sapiens (Human)
Function: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}. Nucleus {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}. Note=Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}.
Interaction partners:
- Large subunit GTPase 1 homolog
- Proliferation-associated protein 2G4
- Probable ribosome biogenesis protein RLP24
- GTP-binding protein 4
- Eukaryotic translation initiation factor 6
- Exportin-1
- Nucleolar GTP-binding protein 2
- Large ribosomal subunit protein uL18
- Cytoplasmic 60S subunit biogenesis factor ZNF622
- Zinc finger protein 593
Sequence:
MEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVSISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMCGDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPCRYKASQRLISQDIHSNTYNYKSTFSVEIVPICKDNVVCLSPKLAQSLGNMNQICVCIRVTSAIHLIDPNTLQVADIDGSTFWSHPFNSLCHPKQLEEFIVMECSIVQDIKRAAGAGMISKKHTLGEVWVQKTSEMNTDKQYFCRTHLGHLLNPGDLVLGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARERENMDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSAIPVESDTDDEGAPRISLAEMLEDLHISQDATGEEGASMLT
Protein: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (NDST-1) (N-heparan sulfate sulfotransferase 1) (N-HSST 1) ([Heparan sulfate]-glucosamine N-sulfotransferase 1) (HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 (EC 3.5.1.-); Heparan sulfate N-sulfotransferase 1 (EC 2.8.2.8)] (Q3UHN9)
Organism: Mus musculus (Mouse)
Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (Probable). Plays a role in determining the extent and pattern of sulfation of heparan sulfate (Probable). Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q02353}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P52848}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:P52848}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Exostosin-2
- Exostosin-1
- Heparan sulfate 2-O-sulfotransferase 1
- Exostosin-like 3
- D-glucuronyl C5-epimerase
- Heparan-sulfate 6-O-sulfotransferase 1
- Glypican-3
- Heparan-sulfate 6-O-sulfotransferase 2
- Glypican-4
Sequence:
MPALACLRRLCRHLSPQAVLFLLFVFCLFSVFVSAYYLYGWNRGLEPSADASESDCGDPPPVAPSRLLPIKPVQAVAPSRTDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIAPGKGDMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCVAYGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLLAKTRSSESIPHLGADAGLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDDIFVGKEGTRMKVEDVKALFDTQNELRTHIPNFTFNLGYSGKFFHTGTDAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWGIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSSELDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFKHLVRFLHSWTNLRLQTLPPVQLAQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYMEFFPIPSNTTSDFYFEKSANYFDSEVAPRRAAALLPKAKILSILINPADRAYSWYQHQRAHDDPVALKYTFHEVITAGPDASSKLRALQNRCLVPGWYATHIERWLSAFHANQILVLDGKLLRTEPAKVMDTVQKFLGVTSTVDYHKTLAFDPKKGFWCQLLEGGKTKCLGKSKGRKYPEMDLDSRAFLKDYFRDHNIELSKLLYKMGQTLPTWLREDLQNTR
Protein: Mucin-6 (MUC-6) (Gastric mucin-6) (Q6W4X9)
Organism: Homo sapiens (Human)
Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
Subcellular location: Secreted.
Interaction partners:
- Mucin-2
- Mucin-1
- Mucin-7
- Mucin-5AC
- Mucin-4
- Mucin-12
- Mucin-17
- Mucin-13
- Trefoil factor 2
- Mucin-16
Sequence:
MVQRWLLLSCCGALLSAGLANTSYTSPGLQRLKDSPQTAPDKGQCSTWGAGHFSTFDHHVYDFSGTCNYIFAATCKDAFPTFSVQLRRGPDGSISRIIVELGASVVTVSEAIISVKDIGVISLPYTSNGLQITPFGQSVRLVAKQLELELEVVWGPDSHLMVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLEPHKFAALQKLDDPGEICTFQDIPSTHVRQAQHARICTQLLTLVAPECSVSKEPFVLSCQADVAAAPQPGPQNSSCATLSEYSRQCSMVGQPVRRWRSPGLCSVGQCPANQVYQECGSACVKTCSNPQHSCSSSCTFGCFCPEGTVLNDLSNNHTCVPVTQCPCVLHGAMYAPGEVTIAACQTCRCTLGRWVCTERPCPGHCSLEGGSFVTTFDARPYRFHGTCTYILLQSPQLPEDGALMAVYDKSGVSHSETSLVAVVYLSRQDKIVISQDEVVTNNGEAKWLPYKTRNITVFRQTSTHLQMATSFGLELVVQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDTTDDFTTSMGIAEGTASLFVDSWRAGNCPAALERETDPCSMSQLNKVCAETHCSMLLRTGTVFERCHATVNPAPFYKRCVYQACNYEETFPHICAALGDYVHACSLRGVLLWGWRSSVDNCTIPCTGNTTFSYNSQACERTCLSLSDRATECHHSAVPVDGCNCPDGTYLNQKGECVRKAQCPCILEGYKFILAEQSTVINGITCHCINGRLSCPQRPQMFLASCQAPKTFKSCSQSSENKFGAACAPTCQMLATGVACVPTKCEPGCVCAEGLYENADGQCVPPEECPCEFSGVSYPGGAELHTDCRTCSCSRGRWACQQGTHCPSTCTLYGEGHVITFDGQRFVFDGNCEYILATDVCGVNDSQPTFKILTENVICGNSGVTCSRAIKIFLGGLSVVLADRNYTVTGEEPHVQLGVTPGALSLVVDISIPGRYNLTLIWNRHMTILIRIARASQDPLCGLCGNFNGNMKDDFETRSRYVASSELELVNSWKESPLCGDVSFVTDPCSLNAFRRSWAERKCSVINSQTFATCHSKVYHLPYYEACVRDACGCDSGGDCECLCDAVAAYAQACLDKGVCVDWRTPAFCPIYCGFYNTHTQDGHGEYQYTQEANCTWHYQPCLCPSQPQSVPGSNIEGCYNCSQDEYFDHEEGVCVPCMPPTTPQPPTTPQLPTTGSRPTQVWPMTGTSTTIGLLSSTGPSPSSNHTPASPTQTPLLPATLTSSKPTASSGEPPRPTTAVTPQATSGLPPTATLRSTATKPTVTQATTRATASTASPATTSTAQSTTRTTMTLPTPATSGTSPTLPKSTNQELPGTTATQTTGPRPTPASTTGPTTPQPGQPTRPTATETTQTRTTTEYTTPQTPHTTHSPPTAGSPVPSTGPVTATSFHATTTYPTPSHPETTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASNHSAPTGTIPPPTTLKATGSTHTAPPITPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTRTPVAHTNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPTMTLTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVTTSGTSQSRSSFSTAKTSTSLHSHTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSATSSRLPTPFTTHSPPTGTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHTQMATSASIHSMPTGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPYHTSSTHHPEVTPTSTTNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSPPTGSSPFSSTGPMTATSFQTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVIITTHTQMATSASIHSTPTGTVPPPTTLKATGSTHTAPPMTVTTSGTSQTHSSFSTATASSSFISSSSWLPQNSSSRPPSSPITTQLPHLSSATTPVSTTNQLSSSFSPSPSAPSTVSSYVPSSHSSPQTSSPSVGTSSSFVSAPVHSTTLSSGSHSSLSTHPTTASVSASPLFPSSPAASTTIRATLPHTISSPFTLSALLPISTVTVSPTPSSHLASSTIAFPSTPRTTASTHTAPAFSSQSTTSRSTSLTTRVPTSGFVSLTSGVTGIPTSPVTNLTTRHPGPTLSPTTRFLTSSLTAHGSTPASAPVSSLGTPTPTSPGVCSVREQQEEITFKGCMANVTVTRCEGACISAASFNIITQQVDARCSCCRPLHSYEQQLELPCPDPSTPGRRLVLTLQVFSHCVCSSVACGD
Protein: Meiosis-specific coiled-coil domain-containing protein MEIOC (Meiosis-specific with coiled-coil domain protein) (A2AG06)
Organism: Mus musculus (Mouse)
Function: Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26742488, ECO:0000269|PubMed:28380054}. Nucleus {ECO:0000269|PubMed:28380054}. Note=at late pachytene a fraction is nuclear. {ECO:0000269|PubMed:28380054}.
Interaction partners:
- 3'-5' RNA helicase YTHDC2
- 5'-3' exoribonuclease 1
Sequence:
MEVSGGDTCRPRHPQGLREGPEPKVAAAAAAFRGSANRCWNLSVDTSNRLSDVFNSMMLTGSAPFYDCYKSQNEDNVDLRQTCTPLSSSTEYASSIDSSLFYAPWSTYGDDIKQPPSSQISVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFVDHHDLLTEPKRPVDTSISQQAFYSGESVSAVEKQYLHNSSLTPQQKIDELYHGYTGLDLEEQWLYLSRSDHSNCYNSQANDTVKATFQEYPFVKNCFTPQTGLSDIMKESGIDTYAYGREKICTKGLETPLQHKRAEIFLSQFNRYNENADYCRYPEYAHPNKAKLNKCSNFSVQDGKKLANGTPETPTVEADAYTKLFQVKPANQKKMEETIPDQQNFAFPKTTPHLTEKQFAKEAAFTADFGLKSEYGLKPHTACPTNNDFANVSEKQQFAKPDPLNSEYFKSVNLFSNSATSSGGISLNRPTWMNVQTKNNLPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTSNSNLFQKYCQENPSAFSSFDFSYNGAERIQSVNHMEGLTKTGEDNLFESVTEKKIKQPNGFCDSYSASQYGIIENVNKHNFQAKPQSGHYDPEDIPKHFDGLPQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGDLRHNQGFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNSFSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKVSSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALATAIKEMCVATRKARTTLWCALQMTLPKTASTAGQADMEKAFQDLVNCEEKVHESINSSNPMNQRGETSKH
Protein: SD10611p (Q95R41)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNVFSRAELNRSEIQILIDYLLNKQQDMPASHSEWSDDICQKLKRQLEEKEKLLAEEQEASIGIQAKLRELRQEVNTERAQMHARNQAYIDKLQGKEQELAALNQELSSLNDKLTLERQQLTTLRREKQANSQDLVQLQHLQQDLAHKEKCLAEMTAFVNAETQQKNEVIQQQAQQLQALELQREELEARQNNSIFELEQRKQLEAENADLKQELSAVQQTQSELQRVHAAELQELRQNLSVLEARNVALSQQLTQAANSAVQATAAQSEQAQVQTEALAQKQQELSALRSQVGSLTDAHAQQQKQANALQSQLQEAQQRAEQLQAKEQHLQQELQEQREKNNQQHKELQLQQQKAVAANGGGSASSAKSEQQRIRDLYQRLYPDAVKAQSGNALQASFDQWLEQVLATHVKQQQDKLRQKLDAEKSEKQSSSSHKSTQSSNSSSSNHNSTHNNISSNNSSSNSQSSSAAEQQELHKQNLQLRECNDKLTQLVTKTTNTLMDLEERAREQDEHWRGIVEQKEQLILTLQQHASNGE
Protein: Desmoglein 2 (A0A8I6AG90)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, desmosome {ECO:0000256|ARBA:ARBA00004568}. Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MRVLKATHTHSDTPTPTRSPSNSITPWDLTIHFGNLTRGEDRLFTKRTHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGIKITYKYTGKGITEPPFGIFVFDRNTGDLNITSILDREETPFFLLTGYALDSRGNNLEKPLELRIKVLDINDNEPVFTQEVFVGSIEELSAAHTLVMKITATDADDPQTLNSKISYRIVSQEPANTPVFYLNKDTGEIYTTSFALDREEHSSYSLTVEARDGNGQITDKPVQQAQVQIRILDVNDNIPVVEYGTYEGVVEENQVNVEVMRIKVTDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVTLVKELDYEEMKKLDLSILVTNKAAFHKSVVSKYKATPIPITVKVKNVVEGIHFKSSTVTFRASEAMDRSSLSRSIGKFQVFDEDTGKAADVTYVKVQDTDNWVSVDSETSEIKLVKIPDFESRHVQNGTYTVKVVAISKGHPQKTVTGTILINVEDVNDNCPVLVDSVRSVCADAPYVNVTAEDLDGPRNSGPFTFSIIDQPPGTAQKWKITHQESKCTSVLLQPSERKLGRSEIPFLISDSQGFSCLERQVLQLTVCECLEGGGCVAALYDNYVGLGPAAIALMILALLLLLLVPLLLLMCHCGEGAKGFAPIPGTIEMLHPWNNEGAPPEDKVVPSLLVTDHVENSGVRGGGGGGGGGVGGVKLKEGVSSSASITKGQHELIEVDGRWEEHRSLLTSGLTHHVATAGSIAANDTTIRTTRATGASRDMSGARGAVAMNEELLRSYFTEKAASYAGEDDFHLAKDCLLVYSQEDTDSLRGSVGCCSFIEGELDDLFLDDLGPKFKTLAEVCLGRKIDMDVDIEQRQKPVRETSVNAAPGSHYTQVTASSESTYSSNSGFQAPKPLHGAHTEKVTQEVVTESSVSSRQSQKVVPPPNPVASGNIIVTETSYAAGSAVPPSTVILAPRQPQSLIVTERVYAPASTLVDQHYANEENVLVTERVIQPNGGIPKPLEVTQHLNDAQYVMVRERESILAPSSGVQPTLAMPSVAAGGQNVTVTERVLTPASTLQSSYQIPSEASIKARKTVLSSVGGMGPLPNLDLEESGPPNSTVTTSSTRVTKHSTVQHSYS
Protein: Serine/threonine specific protein phosphatases domain-containing protein (E0R7L7)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MCDLLWSDPQPINGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGDNLTPRFTPFDAVPHPKLPPMAYANSLFGFN
Protein: Glutathione S-Transferase (Q9NAB0)
Organism: Caenorhabditis elegans
Interaction partners:
- Probable glutathione S-transferase 7
- Probable glutathione S-transferase 5
- Uncharacterized protein
- CYtochrome P450 family
- Uncharacterized protein
- Probable glutathione transferase omega-2
- Putative UDP-glucuronosyltransferase ugt-47
- glutathione transferase
- Gamma-glutamyltranspeptidase 1
- Gamma-glutamyltranspeptidase 1
Sequence:
MPLYKLTYFDARGYAEPARILFHLAGVPFEDNRLTHGDGSWEKIKDKTPFGQVPVLSVDGFDIPQSAAIIRYLANKFGYAGKTPEEQAWADAIVDQFKDFMGAFRQLIMAQRSGKPAEEIAKISSEVAIPARDSYFKILNGLLEKSKSGFLVGDGLTFADIVVVENLTTLEKNQFFTASEHPKLSALREKVHAVPAIKTWVATRPDTQF
Protein: Uncharacterized protein C2H8.05c (Q9Y7S8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MQDSSKNKQPCVSWKVSPLKAKAMSPDDVSRLFCKSSTSSATRKHDPFHKLWDRLQPKAQSTIQRTSSLPVPSSSNFKERLNNIGGLKRSRTLESSYEDETETANKLSRVSSLVSVIRQTIDRKKSLERRVREEQEEKTDNEDDNDVEISTQESLENNGLAEKKDDTSSLATLEDDIEGQEFSFDDQDLQMLQDIEDQWLSSQKQQGSPLTSDHISK