wanglab/gogpt-training-data huggingface dataset:
Protein: WASH complex subunit 1 (WAS protein family homolog 1) (Q8VDD8)
Organism: Mus musculus (Mouse)
Function: Acts as component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:19922875}. Recycling endosome membrane {ECO:0000269|PubMed:19922875}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:23974797}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:20308062}. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2 (By similarity). Localized to Salmonella typhimurium entry sites (PubMed:19732055). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000269|PubMed:19732055}.
Interaction partners:
- WASH complex subunit 5
- WASH complex subunit 4
- WASH complex subunit 2
- WASH complex subunit 3
- Sorting nexin-27
- TBC1 domain family member 23
- DnaJ heat shock protein family
- Exocyst complex component 8
- F-actin-capping protein subunit beta
- Vacuolar protein sorting-associated protein 26A
Sequence:
MTPVKTQCSLAGQLYAVPLIQPDLRREEAIQQVADALQYLQNISGDIFSRISRRVELSRRQLQAISERVSLAQAKIEKIKGSKKAIKVFSSAKYPAPEHLQEYGSIFTGALDPGLQRRPRYRIQSKHRPLDERALQEKLKYFPVCVNTKSEPEDEAEEGLGGLPSNISSISSLLLFNTTENLYKKYVFLDPLAGAVTKTHTMLGTEEEKLFDAPLSISKREQLERQAPENYFYVPDLGQVPEIDVPSYLPDLPGVADDLMYSADLGPGIAPSAPGAIPELPAFHTEVAEPLQPELENEVLLAAPPPPPPPPPPPPPAPTALVSTPQPPMFPDMATAAGQVAREEDSSSSMAHTASVQGAPKEVVDPSSGRATLLESIRQAGGIGKAKLRSVKERKLEKKKQKEQEQVRATSQGGDLMSDLFNKLVMRRKGISGKGPSTGTSEGPGGAFSRMSDSIPPLPPPQQPAGDEDEEDWES
Protein: Homeobox protein Hox-B2 (Homeobox protein Hox-2.8) (Homeobox protein Hox-2H) (K8) (P14652)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein PKNOX1
- Pre-B-cell leukemia transcription factor 1
- E3 SUMO-protein ligase EGR2
- Homeobox protein Hox-B5
- Homeobox protein PKNOX2
- Homeobox protein Meis1
- Homeobox protein Hox-B1
- Homeobox protein Hox-B3
Sequence:
MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGASTLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRAAWEACCHPPEVVPGALSADPRPLAVRLEGAGASSPGCALRGAGGLEPGPLPEDVFSGRQDSPFLPDLNFFAADSCLQLSGGLSPSLQGSLDSPVPFSEEELDFFTSTLCAIDLQFP
Protein: Ssh1p (A0A1D8PDL0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Translocon subunit
- Protein transport protein SEC61 subunit alpha
- Protein transport protein Sec61 subunit beta
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL22
Sequence:
MSGFRLLDLVKFFLPILPEIEYPFEKVSFDEKIVFTVGSAIIFLFGQLPIYGLIPNAQFYLLDPFSNFRSIFAMNKGTLLELGLLPIITSAFIWQIAAGLRLINVNFKLRIDRELFQTGQKLTSFIFSLIFAIGLIYSGYYDNAIRGYNPLQDGIPYGSYALILLQITAWSWIVTLLVEIFDKGYSFGSGILCFLAIQSSTNFIANLLGLENFPVVNSNKFESYGALMNLIKNFSIFNPKQTVYQIWHSFFRIQLPNLTQFYISLASILIVVALQNFRIELPIRSTKVRGMNNVFPIRLLYTGGLPVLFAFTVVANIQVVGYLIHSVLSKLGTSPIVISIIGNYVYNPSSNELDLNSGILNYFTSSSSLVESIISPIKTTVYSITIIVLAVWFANKWSYISGSSPKDISKQFKDQGISLAGKRDISITKELSRVIPVASVSGAFILSVVALIGDFFGGLGYGVASIIGVTASFAVLEEFMTEYQQNGGGQFSNALASFQ
Protein: H(+)-transporting two-sector ATPase (EC 7.1.2.2) (Q8T464)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MATIQVYEDTSGVSLGDPVYQTGKPLSVELGPGIMGSIFDGIQRPLRSISELTNSIYVPKGIDTPSLPRNIAYEFTPGKLKIDALITGGDIYGSVFENSMMHDHRLILPPRTKGRIRWLAPPGNYCVDEVIVETEFNDEITKHTMLQVWPVRRCRPVEDKLPSNSPLLTGQRVLDAFFPCVQGGTTAIPGAFGCGKTVISQALSKYSNSDVIIYVGCGERGNEMSEVLRDFPQLEVEVNGTMESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADAGYPAYLGARLASFYERAGLVKCLGSPDREGSVSIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLQSYSKYMRTLDTYYEESNPEFTHLRAKAKKVLQEEDDLAEIVQLVGKSSLNEEDKITLEVAKMLKDDFLQQNSYSQYDAYCPFFKTIGMLKNMMTFYDAAILSVQNTADNEARVTWGLIRIKAANILYELSTMKFIDPKLGEATVLESMNKLHDNILSTFREIEDNVEDY
Protein: Ubiquitin-like domain-containing protein (Q5BE39)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- SUMO-conjugating enzyme UBC9
- Nuclear pore complex subunit Nup133, putative
- Ubiquitin-like activating enzyme
- Nucleoporin NSP1
- SUMO activating enzyme
- Ulp1 protease family protein
- Myosin-binding domain-containing protein
- Ran specific GTPase activating protein An-RanGAP
- SUMO ligase SizA, putative
- MIZ zinc finger domain protein
Sequence:
MSDPSAPTPEAPAPVEHLNIKVTDNNNEVFFKIKRTTTLKKLMDAFCDRQGKQPSTVRFLFDGTRVRPEDTPDTLDMADGDTLEVHQEQIGGGL
Protein: CUGBP Elav-like family member 4 (K7EJD7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFVDRATNQSKCFGFVSFDNPASAQTAIQAMNGFQIGMKRL
Protein: Cystatin-related protein 1 (CRP-1) (Androgen-regulated 20 kDa protein) (Prostatic 22 kDa glycoprotein P22K16/P22K20) (P22282)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MCKTLHGTLLLLAIFVLFLNFSHATAKRTRRGMEIFEKNFIDKNKLKDVYDVFKYLYNTHSADTYLSNIKNESFTMNIWGFGEIEMVKTKCRKIDSDFYKCSFQREFYNLKRTPGETMYYISLPGSVRCRKLLSKLDNCPFEEQTEQLKREICYFVVYPDYIEQNIHAVRFDCYTK
Protein: Endoglucanase Cel5A (EC 3.2.1.4) (Cellulase) (Endo-1,4-beta-glucanase) (P84194)
Organism: Gloeophyllum trabeum (Brown rot fungus) (Agaricus trabeus)
Function: Has avicelase and carboxymethylcellulase activity.
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:15870328}.
Interaction partners:
Sequence:
VTGPAPLKFAGVNIAGFDYDALVQAXLNXGYLDSDNSGTLAINTETGGGNTASXVE
Protein: Guanylate kinase (EC 2.7.4.8) (GMP kinase) (P9WKE9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Essential for recycling GMP and indirectly, cGMP.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase subunit omega
- GMP synthase
- Adenine phosphoribosyltransferase
- Hypoxanthine-guanine phosphoribosyltransferase
- Coenzyme A biosynthesis bifunctional protein CoaBC
- Nucleoside diphosphate kinase
- Pyruvate kinase
- Integration host factor
- Bifunctional
- S-adenosylmethionine synthase
Sequence:
MSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRERIPNLHFSVSATTRAPRPGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHRSGTLAQPVRAAAATGVPVLIEVDLAGARAIKKTMPEAVTVFLAPPSWQDLQARLIGRGTETADVIQRRLDTARIELAAQGDFDKVVVNRRLESACAELVSLLVGTAPGSP
Protein: SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) (Q63553)
Organism: Rattus norvegicus (Rat)
Function: May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:10930554}.
Interaction partners:
Sequence:
MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAGDSVLNGHRSKGLCDPAKKDELPELAGPALSTVPPASLKPAASGRKCLFRVEEDEEEDEEDKKPVSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGLAYSWHRRDSSEGPPGSEGDGGGQSKPSGGGGVDKASPGEQGTGGSGQGGSGGTPSGTAGSSRRCAGPDSSSSSPASAAPRGAELVQSLKLVSLCLGSQLHGAKYILDPQKALLSSVKVQERSTWKMCISAPGPGPSADLDPVRTKKLRNNVLQLPLCEKTISVNIQRSRKEGLLCASSPASCCHVI
Protein: Guanosine-diphosphatase (GDPase) (EC 3.6.1.42) (Q8TGH6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:12455990}; Single-pass type II membrane protein {ECO:0000269|PubMed:12455990}.
Interaction partners:
Sequence:
MINPRNLRLIIAVIGLVGIFAFFASSQHSLVDRTALQVNKPAADSPHVPPPAAAAAPVSPPPPSQQQKQQEGSQKQLNDENSDEKNTLQGTSYSGTKPPYEKVDGKSNKILADKLDTTKNSKPNQQQQQNTQKGASEEKSAQNKITTPEEVSMDNGKCNDIDYVVMIDAGSTGSRVHVYEFNTCVKPPQLLSEEFEMLKPGLSSFDTDTVGAAKSLDPLLEVALKKVPKNKQSCTPVAVKATAGLRLLGETKSKAILDEVRSHLEKDYPFAVVSEDGISIMDGKDEGVYAWVTANYLLGNIGGKEKLPTAAVFDLGGGSTQIVFEPDYKVDEVPVDGETKYHFTFGDNQYTLYQFSHLGYGLMQGRNKVNQLVLKNKLSELNLQKYTKKEVKGAKATVDVSNPCIPPGVVAKDVQVELGEDEFYVVNMKGPSSKDSTVAGGSQCRYLAEKVLNKDAECTSKPCSFNGVHQPSLTRTFNKNSDMYVFSYFYDRTNPIGMPSSFSVEELKDLSKLVCQGETFWKDILLDDHVKNLNEEPQWCLDLSFITAMLHTGYDIPLHRELKTAKTIDNNELGWCLGASLPLLDKNNAKWTCRIDKTD
Protein: MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) (O88910)
Organism: Mus musculus (Mouse)
Function: Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K) (By similarity). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:23658188, ECO:0000269|PubMed:23893895}. Cell membrane {ECO:0000250|UniProtKB:Q13368}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q13368}. Note=Localized in apical villi of Mueller glia cells (PubMed:23893895). Localized at the apical membrane in the developing cortex and colocalized with apical proteins and adherens junction proteins (PubMed:23658188). Localized at the outer limiting membrane (OLM), and outer plexiform (OPL) of retina (By similarity). {ECO:0000250|UniProtKB:Q13368, ECO:0000269|PubMed:23658188, ECO:0000269|PubMed:23893895}.
Interaction partners:
- CD48 antigen
- Signaling lymphocytic activation molecule
Sequence:
MPVLSEDSGLHETLALLTSQLRPDSNHREEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAMALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDNIDEDFEEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRFKDSKVFMRALFHYDPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKQFQERRLSYRRTTGTLPSPQNFKKPPYDQPCDKETCDCDGYFKGHYVAGLRRSFRLGCRERLGGSQEAKVPTGAESQVLLTYEEVARYQHQPGERPRLVVLIGSLGAHLHELKQRVVAEDPQQFAVAVPHTTRPRKSHERDGVEYHFVSKQAFEADVHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALRHLRTPEFKPYVIFVKPAIQERRKTPPVSPDSEDIASSLDEQQQEMAASAAFIDQHYGHLIDTVLVRQDLQEPAASSELS
Protein: Major facilitator superfamily protein (Q86B08)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGGAVLINSGNSSNTPINEEEPSGLETNFGTTTPNLKKKYLIQYIILYAYLACIFISTFLYDIFIPTLLFHYVEHKFPDLTPQEKSSKSSYYKSYSDGFPFLVMFLFGPLVGYISDRYGRKSNFYLSVLTVMFVIMSCFVSMETNNIYCFYVFHTIGGLYNVSNSVVFSFIYDISDEKDIPVLFTLCGLSMGLGTTIGSLIYAFVPTDKVPYMMLYISSGFALVSLILVPFLIETIHISRENNKNKTFVKKSFENPNPFSTIKSLFTNNGFISWTILLFFSIQYTGQDIWSTFYYYSYLMYNWNQKTIGLFTLGVGGATILYSVLIVPLFLKVLSEKKVITIGFFITFCAHVMLSSSKFSQYLFIFGAIVSSIVPCVSNLLCSVISKSTPQEVQGSVLTGLQSVKALGSFAGAMVANNLLSHFSSDESSIYFPQAIYFLNGVVLFIIMIISILVWRFYKNKIKNNVNNNNN
Protein: CLAVATA3/ESR (CLE)-related protein 1 [Cleaved into: CLE1p] (Q3ECD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signal peptide that regulates cell fate.
Subcellular location: [CLE1p]: Secreted, extracellular space {ECO:0000250|UniProtKB:O49519}.
Interaction partners:
- CLAVATA3/ESR
- CLAVATA3/ESR
- Protein CLAVATA 3
- Receptor protein kinase CLAVATA1
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
Sequence:
MANLKFLLCLFLICVSLSRSSASRPMFPNADGIKRGRMMIEAEEVLKASMEKLMERGFNESMRLSPGGPDPRHH
Protein: Probable acyl-CoA dehydrogenase FadE23 (P95186)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable acyl-CoA dehydrogenase FadE24
- Probable fatty oxidation protein FadB
- propanoyl-CoA C-acyltransferase
- Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase beta1 subunit
- Acyl-CoA dehydrogenase FadE7
- Probable acetyl-CoA acyltransferase FadA2
- Probable enoyl-CoA hydratase EchA8
- Probable enoyl-CoA hydratase EchA15
- Enoyl-CoA hydratase EchA19
- Putative enoyl-CoA hydratase EchA13
Sequence:
MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNFAGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQLERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGEKIFVTAGSRATHIVVWATLDKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEVGKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEFLRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSELK
Protein: Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) (P81287)
Organism: Bos taurus (Bovine)
Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Interaction partners:
- Caspase-3
- Apoptosis regulator Bcl-2
- Actin, cytoplasmic 1
- Glyceraldehyde-3-phosphate dehydrogenase
- Cholecystokinin
- Caspase-9
- Cytochrome c 2
- Cytochrome c
- Caspase-8
- Lactoperoxidase
Sequence:
MAQVLRGTVADFPGFDERADAETLRKAMKGLGTDEETILTLLTSRSNAQRQEIAVAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTDEKVLTEIIASRTPEELRAIEQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDARIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVVVSRSEIDLYNIRKEFRKNFGTSLYSMIKGDTSGDYKKALLLLCGGEDD
Protein: Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42) (Q9JHU3)
Organism: Mus musculus (Mouse)
Function: Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling.
Subcellular location: Nucleus {ECO:0000269|PubMed:20159594}. Cytoplasm {ECO:0000269|PubMed:20159594}. Cell projection, cilium {ECO:0000269|PubMed:20159594}.
Interaction partners:
- Cyclin-H
Sequence:
MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGIPNQALREIKALQEIEDSQYVVQLKAVFPHGAGFVLAFEFMLSDLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLRILGTPSPRVWPEITELPDYNKISFKEQAPVPLEEVLPDASPQALDLLGQFLLYPPRQRIAASQALLHQYFFTAPLPAHPSELPIPQRPGGPAPKAHPGPPHVHDFHVDRPLEESLLNPELIRPFIPEG
Protein: Mitochondrial ornithine transporter 1 (Solute carrier family 25 member 15) (A0A0G2K309)
Organism: Rattus norvegicus (Rat)
Function: Mitochondrial ornithine-citrulline antiporter. Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle. Lysine and arginine are also transported by the antiport mechanism (By similarity). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q12375}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:15057822}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- N-acetylglutamate synthase, mitochondrial
Sequence:
MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLRTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVVGLDRQAKLSDLQNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAASQNTVWSVVKEIFRKDGPLGFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPIPLMLSGGFGGICLWLAVYPVDCIKSRIQVLSMTGKQTGLIRTFLSIVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMSQLEAC
Protein: Serine/threonine-protein kinase PLK (EC 2.7.11.21) (Polo-like kinase) (Q6DRK7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Midbody {ECO:0000256|ARBA:ARBA00004214}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cyclin B1
- Cell division cycle 20 homolog
- M-phase inducer phosphatase
- Extra spindle pole bodies-like 1, separase.
- Cyclin B2
- Cyclin B3
- Pericentrin
- Cyclin-dependent kinase 1
- Uncharacterized protein.
- Protein aurora borealis
Sequence:
MSAAIAKPSAKPSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTSCLTVPPRFSIAPSSLDPALLRKPLSSLNKGTDSPIEKMGKMDQPQREDLQQRDGPEQPDTHLTDMLQQLAVVNAAKPSDRDFIRQEEAEDPACIPVFWISKWVDYSDKYGLGYQLSDNSVGVLFNDSTRLIMCADGDSLQYIDRNSLESYLSVRSYPSALSKKITLLKYFRNYMSEHLLKAGANITPREGDELTRLPYLRHWFRTKSAIVLHLSNGTVQINFFQDHTKLILCPLMGAVTYINEKREFYTYKMTLIEEFGCCKELASRLRYARNMVEKLMACKSSTTAATSAR
Protein: Glutamate decarboxylase 1 (EC 4.1.1.15) (Q8IVA8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSRYSIKKAGAALGFGTDNVILIKCNERGEIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL
Protein: Histone acetyltransferase (EC 2.3.1.48) (D6XIY7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU361211}.
Interaction partners:
- RuvB-like helicase
- Histone H4
- Histone H4
- Histone H3 variant
- Histone H3, putative
- Histone H2A
- Transmembrane protein, conserved
- Bromo domain-containing protein
- Bromo domain-containing protein
- non-specific serine/threonine protein kinase
Sequence:
MVMFEVRQKVYATLHETFHAAIIQEVAHDAHTGQLLYYVHYVEQDSRMDRWLPGSALRERRQGRQADKQQVSKPTGCGITTRGQSRLVAEQEESGSNGATAGSAAKRGATPNCDKVTTTRTRKESSFFYRPKNVQRICMGPYEVETWYFSPYHLARPQVQQGFKQNAEYFTGDMELQLRQDSRDNALRSSVAFTSFVLHICPFCLQPFSEHEDVLRHVRLVCSRFPPGNEIYRDPIRNLTVVEIDGVAEPTFCEHLALLSKLFLDHKALDHDMTPFLFYVLCSIQPHGLEVLGYFSKEKTTPEMYNLSCILVLPQFQSRGIGRFLIELSYELSRREGKIGSPEKPLSDLGEKLYLGYWGDTIVSTLARAIEESHCVTLDYLVQATFMSEADVMRTLQYLKLIDGTQIVVSEESIERCLSKRVQRERSGQNYIFYPHLLSWSPHMYNEVVEQDVAPPVYDLRRAEKV
Protein: Brevinin-2Rh (C0HL03)
Organism: Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
Function: Antimicrobial peptide.
Subcellular location: Secreted {ECO:0000269|PubMed:28012108}.
Interaction partners:
Sequence:
GIMDTLKNLAKTAGKGALQSLLKMASCKLSGQC
Protein: Cytochrome c oxidase subunit 6B2 (Cancer/testis antigen 59) (CT59) (Cytochrome c oxidase subunit VIb isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform) (Q6YFQ2)
Organism: Homo sapiens (Human)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00429}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00429}; Intermembrane side {ECO:0000250|UniProtKB:P00429}.
Interaction partners:
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome b-c1 complex subunit 7
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome c oxidase subunit 6A2, mitochondrial
- Cytochrome b-c1 complex subunit 9
- Cytochrome c oxidase subunit 6C
- Cytochrome b-c1 complex subunit 8
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c oxidase subunit 6A1, mitochondrial
Sequence:
MLDVEAQEPPKGKWSTPPFDPRFPSQNQIRNCYQNFLDYHRCLKTRTRRGKSTQPCEYYFRVYHSLCPISWVESWNEQIKNGIFAGKI
Protein: Calcium/calmodulin-dependent protein kinase 1Db (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase I delta short) (B5MF71)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MARGSEESVNGSWKKQVDDIRKIFEFKEILGTGAFSEVVLAQEKATGDMYAVKCIPKKALRGKESGIENEIAVLRKIKHENIVALEDIYESPSHLYLIMQLVSGGELFDRIVERGFYTEQDASALIKQVLDAVNYLHSLGIVHRDLKPENLLYFNPHEESKIMISDFGLSKMEGAANDIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFINNLMQKDPEKRFTCDEALRHPWIAGDTALCKNIHESVSRQMKKNFAKAKWRQAFNATAVIRHMRRLQLGSSMDSSQHRKQNPTSMPGKSQSVDVSSVHRNDSLEEGVIFV