wanglab/gogpt-training-data huggingface dataset:
Protein: SAM and SH3 domain-containing protein 1 (P59808)
Organism: Mus musculus (Mouse)
Function: Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O94885}.
Interaction partners:
- Sterile alpha motif domain-containing protein 5
Sequence:
MEEDAGAASPAPEPEPEVDPARELEPEAGVSESISRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKYPLHKSNSEDGCVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSSTLDPADWPDGSYPTLDGSSTCNSREQSDDETEDSVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSAEGGEEHVFENSPVQDERSALYSGVHKKPFFYDGSPEKPPEDDADSLTPSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPAGKEGDFVYKEVIKSPPAPRISLGKKVRSVKETMRKRMSKKYSSPVSEQDSGLDGMPSSPASGKPDSEHVDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRPTRRRKKGRPSQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDNQGLSGRSPRDSGCYESSENLENAKTHKPSVLSTKSSTESNLKSFTRSQPGNYPTLPLMKSGEVRKQGEEGRLGRGLAPDTAKSCDVPSVTDLSKNRRSLPVSICRSCETLEGPEPVESWPRSHSLDDLQGDADVGKNVPTEMPETCSQNVPEVPQKTSACTSKALPRGRDPTADVMLLTQSKRFSDPPKTMAKKLDGSVVASNLGIAPPQCIPRDFEAQPPVKPGLTRTSLEGLRKGHDHHPLGTKEGVDGEQSAPETRTQSRHPSQPPPVPAKKSRERLANGLHLVPSPEAPILPLKKASPASPVSPSDCPSPREPRPSSGTEPGSPACTRPPPWLAELPESTSLQEHGVKLGPVLSRKVSCVRGVDLEMLTENKLQAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLEQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGCVASMSDWLISIGLPMYTSTLSDAGFSTLSQVPSLSHSCLQEAGITEERHIRKLITAARLFKLPPSPEAM
Protein: Guanine exchange factor for Rac 30 (Q1ZXH8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: GTPase-activating protein for Rac involved in streaming and development.
Subcellular location: Membrane {ECO:0000269|PubMed:17584488}; Peripheral membrane protein {ECO:0000269|PubMed:17584488}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:17584488}; Peripheral membrane protein {ECO:0000269|PubMed:17584488}. Note=Accumulates in cortical regions of the cell and on phagosomes.
Interaction partners:
Sequence:
MQPKDYMSSSHANWENIQIDSFTSWINQHLSERGLSVKDLSVDFQDGVLLLNLLEILSGKKIARYVRSPKFLQHKIDNIMIAFNFMEKAFDIKVFGCNAKDIVDGNLKQTMGVIFLLIQKIKVNLHLDHLQEQQGETTGTTTTITSTNTTTTPTKPRFYRASMQVNAANRFSHISPNKDQSSSTVATTTTTSTSVVQPQPQPTTATPTTTTATTLTPPVASQQPVSTAPATVTPSTVIPTVTPLNTTTTTTTATSTSTNVPTATTNVPPTATTTTTGTRISPTTGVSVSTIRSKFLFEGGTGNTTGGNEKYNTYSPGSGNTSGVVGPSTSSSLNISSERVLKRTESGYLISGGLSLSGSGSGGIHEPLQRTVSLIEIKLNDHQSKFYDLKKIIFMQSVIRGYLVRSKWRNVLEKYKQHLNEYKKHFMNNKKAYRGLIRVQAIVKGKIQRKKLFKMFPLYRRNEIVKEILSTEDKYVTSLAMVTTHYLKPSEAFLSTQQVRSIFSQIEIIHRYNSLILEKLVSRNKIWYSSGQKIGDIFIEMSAFLKVYTIYVNNYNNSIQTITECMEIPKFASLLEKNRNQFGLDLSAFLIAPIQRIPRYILLLQDLLKNTKESHPDHQDLSLALKKMKDVAEYVNEKKREAENLNQVLTIQSSLTGKFNNLAEPHRRYVKKGTLISNDKIHLYFLFNDLLVKTENKIVSKIRDSARLSNNNSSDKNSKSTFHSPKEIINEGKSKYLNSYFLAGSSLVDSNPDGFTFQIIGVGDANELNSQINNQINNQNNNQNNNQNNNLNNNNDDSPILSFSPFSSSFASTITNSLSSIGNSNNVNNNNNTSSNSGFVNSSNNNINIVNSNGSSPLTNSGHGLNSSFGISSNNNNNLTMPTTSIQLEALSLNEKMTWMGELDECIFQLLEKSKSKKRSLITDADELTTVPFDISVVKDSEFSNVLEKKHSEISWRSKKFYLKNTHLYYHRYSSTESPKEPTKIKCINLILCSVKLAQVVDHPHCFQLITPSRIYFFSCEDSTVLFQWISLIRLSIKKKLESLKDENNNINNFTSIASATSPTSSSSNTTPIVVPIASHSNATGSLSASLGSSFLNQQQRSLEQQQHLNTSNSNLTPLALSSQVLYHINNFISTSTSTSASQSQSQSPSPSPSHSINQKQKIRKLSFYQSRSNTLININNDEDRLNSFPTSTLSVSCLLNNDNHGNNDFDGKSFTNNIDITTTTTTNDDNNNNTTTTQVKKGKDLSCSKELNCSISHDDNSKGSSGYGNNSCGDNINNDESNNNCAECGASDPSWVSINYGVVVCLDCSSIHKNLPEGNVKSVRSLSVAFSDIVKKQEGNIKANNKYEKNIPSGLTKPNPKDSYEIKLSWIKAKYINNNNNNNNSQNGDSTTPTPTPTSTTIHVNNDSTPTSPNLNSQSSPPPTATTTQTENVKLDNGRSSPTPTPTQTENNNNNVLTPTTTTTNTTTSTTTGSRPTTPTILNNEEEHIQGINLKDSTDTSNGKGTWSRGSSHAITERKTSFLDKPRVPVKKEHQGYLFKTSSPTSNNSSDWKKYLFVYKNDVLTYYKVSKKNKRKEKGIIDLFHSVKQESRPKQKYSFTLVTSQRLYFLASETEEEMKIWLDVLSSHTTH
Protein: Cyclic pyranopterin monophosphate synthase, mitochondrial (EC 4.6.1.17) (Molybdenum cofactor biosynthesis enzyme CNX3) (Molybdenum cofactor biosynthesis protein C) (Molybdopterin biosynthesis protein CNX3) (Q39056)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:20164445}.
Interaction partners:
- GTP 3',8-cyclase, mitochondrial
- Molybdopterin synthase catalytic subunit
- Adenylyltransferase and sulfurtransferase MOCS3
- Molybdopterin biosynthesis protein CNX1
- Molybdopterin synthase sulfur carrier subunit
- Sulfite oxidase
- Xanthine dehydrogenase 2
- Molybdenum cofactor sulfurase
- ABC transporter B family member 25, mitochondrial
- Molybdate transporter 2
Sequence:
MISTLRRAVFLRRFPAVVSPIKRAFSSRIDDEFDPQIMNINELNQEMQSIFGQEPSPDGPGTMDFSELKSSKIEPLRSKNIDFRQQIEYHKSTHSSKNDSQAIEQYAKVASDMSKLTHVGIAGEAQMVDVSSKDNSKRTALACCKVILGKRVFDLVLANQMGKGDVLGVAKIAGINGAKQTSSLIPLCHNIALTHVRVDLRLNPEDFSVDIEGEASCTGKTGVEMEAMTAVSVAGLTVYDMCKAASKDISITDVRLERKTGGKSGSWSRL
Protein: Eukaryotic translation initiation factor 4C (Q9SJB9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Eukaryotic translation initiation factor 3 subunit A
- Small ribosomal subunit protein uS10y
- At5g54760
- AT5g54940/MBG8_21
- Eukaryotic translation initiation factor 3 subunit E
- Protein translation factor SUI1 homolog 1
- Protein translation factor SUI1 homolog 2
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein uS10z/uS10x
Sequence:
MPKNKGKGGKNRKRGKNEADDEKRELIFKEDGQEYAQVLRMLGNGRCEAMCIDGTKRLCHIRGKMHKKVWIAAGDIVLVGLRDYQDDKADVILKYMSDEARLLKAYGELPENTRLNEGIVGDLEDDDDNNDDDYVEFEDEDIDRI
Protein: nitric oxide dioxygenase (EC 1.14.12.17) (Q5B7F8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MLKNVLRRGALRLVRQRASYATSALTPQQKQIVKATIPALEQHGVTITTLFYKEMLERHPELNNIFNSSHQATGVQPAALAHAVWAYASNIDHPEALATAVSRIGHKHASLGVRSEHYPIVGEHLLRAIKKVLGDAVTPPVADAWTAAYQQLADIFISFEDDLYKQATQTPGGWTGWRKFVIADKVHESEEIISFQLVPQDNGRLPTYKPGQFVSVRCFVPELGVYQPRQYSLSDIPNQRYFQISVKKEFASGARPAGRISNVLHESLPKGSEVEISMPFGDFVLDTNATTPVVLMSGGVGLTPMMSMLKTVTNNSKSRPAVFVHAVRNGRVHAMKETLANIMTDNPQVKRAIFYEQVEEGDKQGVDYDYVGRVDVSKIKDLVFLPDADYYICGPSPFMKAQSEALETLGVRPDRIHMEVFGSPTP
Protein: Mitogen-activated protein kinase kinase kinase 1b (PpMEKK1b) (EC 2.7.11.25) (MAP kinase kinase kinase 1b) (A9RVK2)
Organism: Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens)
Function: The CERK1, MEKK1a/b, MKK1a/b/c and MPK4a/b proteins are involved in pathogen defense. The pathway induces rapid growth inhibition, cell wall depositions and accumulation of defense-related transcripts. This protein is required for responses to chitin and acts redundantly with MEKK1a.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q39008}.
Interaction partners:
Sequence:
MVEERGSSRSSRGGSWGSGEDGGSSHGGKGVPKLSRTVAKKIHKYDVSADHSDYEDDGSVHSTSSSGSRRNPLSKSIIQQQSFRVGANFEEDLKTLYELIGVSKPADLAISASDWQSRGKSIAYSQPLSSPSLSQEHGEASHSNDLKPSIIDFRSEAPAASPRELPVAPVKLDAHERMTYRSDYVNSQPQNHYGRKNSPSQRSPPPESFPAFDSSPSRLGREGYGLHRMQSDPVMPTLGALSPLGTGNAHPESAGSTATRRWSFDLVPGNHEGDYANMSQVVRDNLPSAAVAMPKNGLVRRSPIIRDPNRSNSSVSNPYAQRQYPNLAEEAESSAKPESSAIPDSSAMPELPAKLESTAVPELSAKPESNAKPESEPEQDSSVEARTEHYGSVRKSKIPSALIIDKFEEPSIVSTGRSPGVVSKRPPWDTWFKGDFIGSGTFGSVYEGIDNNGMFFAVKEVSLKDQGKVGQEAIKQLEHEIALLSDIQHPNIVQYLGTERDDEKLYIFLELVSKGSLASLYKKYYFVYDQVRAYTKQILSGLKYLHDRKIIHRDIKCANILVDTNGVVKLADFGMAKQVDKLGLLKSFMGSAHWMAPEVVNPKRQYNFLADIWSLGCTVLEMATGDAPFGELECHSVLWKVGNGEGPLIPDDLEDEMKDFISKCLEVTVGNRPTCDMLLTHPFITGEPMTGPVKLVPMPELSTISEERSIDVSESPSIATSSQSGSSPSVAGDAVSPASVAVRPRSMRTLRSEFSMSSPESIAS
Protein: Transmembrane protein 131-like (A2VDJ0)
Organism: Homo sapiens (Human)
Function: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23690469}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:23690469}. Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. {ECO:0000269|PubMed:23690469}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum {ECO:0000269|PubMed:23690469}. Note=Transmembrane localization is essential for Wnt signaling inhibition. {ECO:0000269|PubMed:23690469}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:23690469}. Note=Scattered throughout the cytoplasm in small-sized punctate structures. {ECO:0000269|PubMed:23690469}.
Interaction partners:
Sequence:
MAGLRRPQPGCYCRTAAAVNLLLGVFQVLLPCCRPGGAQGQAIEPLPNVVELWQAEEGELLLPTQGDSEEGLEEPSQEQSFSDKLFSGKGLHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLPTEEGSIESSLFINTSSYGVLSYHVSGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQMQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNFTKIASFTCKATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSVVLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVIAHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFSATALRSRMIKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNLTLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPDLPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLPQYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPINPTTEHSTHMENQAVVCKEYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV
Protein: Fatty acyl-CoA reductase wat (Protein waterproof) (EC 1.2.1.84) (Q8MS59)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the reduction of saturated fatty acyl-CoA to fatty alcohols. The preferred substrates are C24:0 and C26:0. Necessary for the final stages of tracheal maturation, to facilitate the transition from water-filled to gas-filled tubes. May help to maintain the integrity of the outer hydrophobic envelope of the trachea.
Subcellular location: Apical cell membrane {ECO:0000305|PubMed:24183938}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MDDPKIMNIMNGMKSLEDHCQLISDVKDESPMQMFYKDKGVFLTGGTGFFGKIIIEKLLRVTEVGQIYLLIRTKKGKDAFARIEDLFNDPVFAKMKQVNPKYRCQITIISGDCSLPGLGISADERETIMENVNIVLHSAATVRFDEKLKMAIAINVHGTKEIIKLAKEIVNLKALVHVSTAFAHCNMRHIQERFYSGTMSGENAFKLSECLDEHTLNTLTPTIIKGYPNTYTFTKVLAENVVQQSAQNLPVTIFRPGIVITTYREPVTGWIDNMYGPCGVIVGIGSGVLRVFTGDMDNKAHIVPVDMCVNALLASAWDIARNKYETPPIYNYVPDAENMVTWRRYMEDGFEYGCDIPMRKSIWYPRFTIVPHMWQYHILCFLYHTLPALVMDAIMVIIGKKPRMMKIYRKIHKLSNVLKYFSSNEFRFDNDNVRKLTEKLDDRDKRLFAFDMRDLDWTNLFRVSLYGLRLYVVKDDPSNIPESIKRYERLKVLHYTTLAVFYALAAWALYALLKLFL
Protein: 26S proteasome non-ATPase regulatory subunit 1 (Q54JM5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 11
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit 8
- 26S proteasome regulatory subunit 7
- 26S proteasome regulatory subunit 6A homolog
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 3
- 26S proteasome non-ATPase regulatory subunit 2
Sequence:
MVAINSVSNYLSLLDEDQLELKSYSLEKLDSCVDEFWSEIASSSIDKIKSLSVNKQFPKHELASLVLSKVYYNLSDFPNSMEYALSAGSLFNVLSKSEYIETLLYKFIDEYIKLRTSTNKDTVINPHLESIVMGMFDRCFKEGSYKQALGIAIEARRLDIIEKAISQSGNVNSMLSYCLHICNVSVNNRHFRHSVLGILVNLHLAQEKPDYLSVVQCLIFLDNHIEVATILLSLIKKDEESLLLAYQIGFDLFQNSTQQFLLNVRNRLPPVEKKSTTTTTTTPASDSMEIDIDSGNEKSGGSSSFEQRLERLHSILIGDVSIGMNLEFLYRNCSTDMHILQSMKTTSELHKGAIFYSGTLFANALMHAGTTRDTFLRSNIEWLYKSTHWTKFSAISSLGVINKGHIKESKSLLKTYLPGASVNQTPYSESGSLYALGLIHASHGEEIIDYLVEKLHINNAILHHGASLGLGLAAMATGRDDLYEDLKSVLYNDDAVSGEAAGLAMGLVMLGSGAKKAIEEMLAYAHETQHEKTIRSLSMGLAFLMYGKEESADTLIEQMIGDKDPLIRYGGMYAIAFAYCGTGHNDALRKLLHVAVSDGTDSVRRAAVTCIGFVLSRQPEKCPKAIALLAESYNPHVRYGAAFALGIACAGTGQRDALEILKSLTTDSVGYVKQAAWISMAMVLIQTSKELVPEAETARKLFATCISDKREDSMSKFGAVLAFGVIDAGGRNSTIQLHSPSGHKNMNAIVGIAGFLQFWYWFPMTHFMGLALTPTSIIGLNKNLEMPVFTFKSNCRPSLFAYPPETKPSTTSSTNKIETAILSYSRKNKLQSSRSAMNIDQDVEKKEKEEKEAKEKEAKEKEEKEAAKAEEKEPLFERKSNPARIVPRQLQYVQFDDARYQPIKKSPAIGIVMLRDLTPNEPEQLVVKEKPETKQETVGNQSGTATATASLPNATTTTSPTLPEPSTPEPFEFTE
Protein: Ras-related protein Rab-21 (Rab-12) (P35282)
Organism: Mus musculus (Mouse)
Function: Small GTPase involved in membrane trafficking control. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16754960}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19745841}. Golgi apparatus membrane {ECO:0000269|PubMed:16754960}. Early endosome membrane {ECO:0000269|PubMed:16754960}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16754960}. Cleavage furrow {ECO:0000269|PubMed:18804435}. Cell projection, neuron projection {ECO:0000269|PubMed:19745841}. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (PubMed:19745841). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435). {ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:19745841}.
Interaction partners:
- Rab5 GDP/GTP exchange factor
- Ankyrin repeat domain-containing protein 27
- Myotubularin-related protein 13
- GTPase-activating protein and VPS9 domain-containing protein 1
- Integrin beta-1
Sequence:
MAAAGGGAAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDVTDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQAGAARRGVQIIDDEPQAQSSGGCCSSG
Protein: Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1) (Q15040)
Organism: Homo sapiens (Human)
Function: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23625928}. Cytoplasm {ECO:0000269|PubMed:23625928}. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding.
Interaction partners:
- Ataxin-3
- Polyubiquitin-C
- Ataxin-3-like protein
- Ubiquitin carboxyl-terminal hydrolase isozyme L3
- COP9 signalosome complex subunit 5
- Ubiquitin carboxyl-terminal hydrolase 1
- UV excision repair protein RAD23 homolog B
- Zinc finger-containing ubiquitin peptidase 1
- Transitional endoplasmic reticulum ATPase
Sequence:
MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGKNCELLLVVPEEVEAHQSWRTDV
Protein: GH23453p (Q961H2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Solute carrier organic anion transporter family member
- ABC-type glutathione-S-conjugate transporter
Sequence:
MPRSDTEALVADVETGEDSAPRILDASSAASSEQVDPPPVPPPHDYSSYRWFILEPAVFLIFFARNLIGAVYQNQILYQTCITIEKFNATQCEPLLGIDRGSDADKEVEVIVQTYSANIMMTTSLLESIIPAFASLFLGPWSDKFGRRPILLTTFTGYLTGALILIVITYITRSTNISPWWFLLSSVPSVVSGGTCALITGIYCYISDVAKERKKALRMVLNEASLCAGIMVGNVASGYIYAATNALVLFSIAGSLMMFALMYVLLFVPESLNPGDIHTGSRVREFFRFDLVTDLIRTCFKRRPNFDRTIIWLTMIALTIAIFDMEGESTVNYMFVQDKFNWTIKDFSLFNASRIVIQIVGSIVGMLVLRRVLKMSIVTMAMLSLACCVLESTVRATAVYWQELYLGMTLGMMRGVMGPMCRAILSHVAPATEVGKIFALTTSMESVSPLGAAPLYTTVYKATLENYPGAFNFISAALYFVCYILIAVIFGIQKSMGSSSVYQAIGS
Protein: P25-alpha (D6XFL0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Katanin, putative
Sequence:
MEAVFYAFASFGTAPTKEMDNAHFSKMLKEAKIIGKTFTSTDADLLFNKIKAKGARKITFTEFNTRALPDIATKLKMTPEQVAEILTKASPASNSTKAEAVKFHDDKNLYTGVYKAGGPTNVDRNAGSLSGVVDRRVDQVDVRGTTSSQK
Protein: Uncharacterized transcriptional regulatory protein C1683.13c (Q9P6I9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:10759889}.
Interaction partners:
- Putative D-3-phosphoglycerate dehydrogenase
Sequence:
MQMKPRQDKKNQEIFRISCQRCRQRKIKCDRLHPCFQCVKSNSQCFYPEDPIRRRAPKEYVEALERQIAFFEAFVKKLAKVGSDEQSLMIQDMNNKIVNEGNEYDQTPDISARKRRKHFRMLPQNNFRYFQFYGTTNVISASNLTTTSEIPTFKFPIFSKRKYNDTENLYEQPFHLEFDTCQELLSLFFLKQYHNFMFVFRDYFIRDFELGGGPYYSQWLLFAICSIGAMISPDDDLKNLSNTLANIAEKWVLDEGLNSPDITTLQTLLVLGIREIGRGLTFKGWLFSGMAFRLVYDMGLHLDPDHWDHSEESRIDREVRRRCFWGCFTLDKLISLCYGRPPGLYLKQTDVRNTTQLPYISELDEPFEIFNKKSELFAAVSAGEDRRGLVQFWLNQVELCKIIHRMLTEVFEDRTSSVLEASINNIHTELQKWIADIPMELQWNTRSQKETSSTVLLLHMLYHSVIIILNRPSDDNYLKLDNTERYTFEICWKSAKTIVQLLKIYFKKYDADCLPMTFIHIATSAARIILVKLNENIPEDGDVCNIYLEIITNALDVCANVWPLASQASRAILNAYKSCATSPKENNEDSLPLQRSPSLDDVSRFDSLDYIFSPNVKY
Protein: IQ domain-containing protein F1 (Q8N6M8)
Organism: Homo sapiens (Human)
Function: Involved in sperm capacitation and acrosome reaction.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:25380116}.
Interaction partners:
Sequence:
MEEKQPQKTKEPSKEDEPQQKEMPTHLSLGAESKAEAKTPVLVETQTVDNANEKSEKPPENQKKLSDKDTVATKIQAWWRGTLVRRALLHAALSACIIQCWWRLILSKILKKRRQAALEAFSRKEWAAVTLQSQARMWRIRRRYCQVLNAVRIIQAYWRCRSCASRGFIKGQYRVTANQLHLQLEILLDSGPCIVTECIPFSIKE
Protein: Sodium channel regulatory subunit beta-4 (Q7M730)
Organism: Rattus norvegicus (Rat)
Function: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12930796}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8IWT1}.
Interaction partners:
- Sodium channel regulatory subunit beta-1
- Sodium channel protein type 5 subunit alpha
- Sodium channel protein type 1 subunit alpha
- Sodium channel regulatory subunit beta-3
- Sodium channel protein type 7 subunit alpha
- Sodium channel protein type 8 subunit alpha
- Sodium channel protein type 2 subunit alpha
- Sodium channel protein type 4 subunit alpha
- Sodium channel protein type 3 subunit alpha
- Sodium channel protein type 9 subunit alpha
Sequence:
MSRAGNRGNTQARWLGIGLLGLFLLPMYLSLEVSVGKATTIYAINGSAILLPCTFSSCYGFENLYFRWSYNNSETSRILIDGIVKNDKSDPKVRVKDDDRITLEGSTKEKMNNISILLSDLEFSDTGRYTCFVRNPKEKDLNNSATIFLQVVDKLEEVDNTVTLIILAVVGGVIGLLVCILLLKKLITFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPTKV
Protein: Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) (Q8BUH8)
Organism: Mus musculus (Mouse)
Function: Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation. Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (By similarity). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (By similarity). Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28095500}.
Interaction partners:
- Small ubiquitin-related modifier 2
- Chromobox protein homolog 5
- Small ubiquitin-related modifier 3
- Small ubiquitin-related modifier 1
- Ran GTPase-activating protein 1
- SUMO-conjugating enzyme UBC9
- SUMO-activating enzyme subunit 1
Sequence:
MDRARPGRRRASSEIVTEGKRKKSSPADLQKITKLLTVKSEDVLAQSPLSKLRGSECWWTRSLRNKVICLDHKKPKAARGCPPKGLPKRHLRVMLTNVLWTDLGREFRKTLPRKDANLCAPSKVQSDSLPSTSVDSIETCQRLDPLHQSLNLSERTPRVILTDIRQTELGRKYLKIPPVTEASLSDTANLKSEQLSSSSDGSLESCQSVNHHKSFLSESGPKPSRTGDVPAKEAACGGQKQGDDGGVTPEMAAPHPKDFNTGNKGCDYLEEGTSNKNTSYSYSEMDHTPVSRKRKKRGRSNFHDSHNSKTSLDKPTEHTKEEENDSSVSRKLEESGEDSHQDPAPPEGLAPESLESEATNLRSFAAGQEPDASAASGRASSPNKSLESSASSEVSENSSVAVKGEALTLKEASPPGGSSEESQLLISAEPIVVSSDEEGPVEHKNSVILKLQPPHEIMSENQGTSDPQLSELTLGACESVQVTSELFPYNPDVENISCIKSNSEMDLKLDFIFTCVYIGKIKGTPKGCVTFTKKYIKIPFQVSTNEISLTVDTARLKRFGLWESKDEDHSKRSHAILFLWLSSDYLQDIQTQLENPMLSQQSKANEFIFLELNSSISQREELKLKDIMMEISTKNGNLHLSCPLPWVQALPLFQDLSPQEISFLHYYYASASALPTAAGADMKKKSVSQPSNSDTIKPTYTFLHKQSSGCYSLSITSSPEEEWQEVRNTGPVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLLLEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPDLSVAQRRHRRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDCPQTVSQQFQGQQSQHDHKMTDNDPHTTSTVSTSAEDSQSTEVNMSVPKKMCKRPCILILDSLKAASIQNTVQNLREYLEVEWEVKRKTHREFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFQDPIVNFELPIHLEKWFPRHVIKTKREDIRELILKLHLQQQKGGSC
Protein: Central complex broad (IP09483p) (Q9VRF5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- MIP34364p1
- TAR DNA-binding protein 43
Sequence:
MTIMAISNDTFENEQQVAVRQEAPNAIGNIPDVVESASRPQKYTFHEIYQMITALTWPRILFDLLVRHEWNSIFLSLGFLILNAFEVLQSFNLLQQLAVVGMMILSNIMIYKAIRPYVRFHLYERLIRADFNVHITQEMVVRVVNCVNRCLVTLHCILFQTEIFELFLMMLALEAVRNIIWYTNIFLLIRIVLCVTLFFPRLFDNDIDNASSRAYYQICVLQIVDKLEEIGVEVHLGIIERWKQEVDAMRELYYEIEDWPNQE