wanglab/gogpt-training-data huggingface dataset:
Protein: Guanine nucleotide exchange factor VAV3 (VAV-3) (Q9UKW4)
Organism: Homo sapiens (Human)
Function: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
Interaction partners:
- Lymphocyte cytosolic protein 2
- Tyrosine-protein kinase SYK
- Cell division control protein 42 homolog
- Transforming protein RhoA
- B-cell linker protein
- Ras-related C3 botulinum toxin substrate 2
- Tyrosine-protein kinase ZAP-70
- Integrin beta-2
- Growth factor receptor-bound protein 2
- Tyrosine-protein phosphatase non-receptor type 11
Sequence:
MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEINLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
Protein: Polyubiquitin-B [Cleaved into: Ubiquitin] (P0CG62)
Organism: Gallus gallus (Chicken)
Function: Ubiquitin Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
Subcellular location: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P0CG47}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0CG47}.
Interaction partners:
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-conjugating enzyme E2 variant 1
- E3 ubiquitin-protein ligase parkin
- Ubiquitin B
- Uncharacterized protein.
- Uncharacterized protein.
- Ubiquitin-ribosomal protein eL40 fusion protein
- UBIQUITIN_CONJUGAT_2 domain-containing protein
- Ubiquitin carboxyl-terminal hydrolase.
- Ubiquitin-conjugating enzyme E2 K
Sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGY
Protein: Siroheme biosynthesis protein met8 [Includes: Precorrin-2 dehydrogenase (EC 1.3.1.76); Sirohydrochlorin ferrochelatase (EC 4.99.1.4)] (O14172)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD-dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable uroporphyrinogen-III C-methyltransferase
- Probable phosphoadenosine phosphosulfate reductase
- Probable sulfite reductase flavoprotein component
- Adenylyl-sulfate kinase
- Uroporphyrinogen-III synthase
- Sulfite reductase subunit beta
- Porphobilinogen deaminase
- U6 small nuclear RNA
- Sulfate adenylyltransferase
- Probable sulfate permease C869.05c
Sequence:
MASKYQSVQPGGSLIIAWRAQGKKVLIVGGGVVAAGRILHVLNADAHVIVVSPKAGLCKEVAWRIQEKQVEWRDRGFLVEDLSDDVNMVLTAIDDPSLSSEIYKLCKSKKIPVNAADIPPECDFYFGSEIRNGPLQIMVSTNGKGPKLASLIRKKIESSINPATGMALEKTGLLRQKLRDIVPEPENSRKRMRWMIEICELWSLEELAMLDENLINRLLGYFPKKTPSYREITTPAYSKIDNYIWFGAIIISGAVLLKHVSKAR
Protein: Rho GTPase activating protein at 18B, isoform C (Q9VWL7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ras-like GTP-binding protein Rho1
- Kinesin-like protein subito
- Kinesin-like protein
- Arfaptin
- Pebble, isoform B
- Ras-related protein Rac1
- ADP-ribosylation factor 6
- Sister of feo, isoform A
- Fascetto
- PH and SEC7 domain-containing protein
Sequence:
MPQQAKDINDNVGMEAHIYENLPGLTSTPKGHLNAELRKYFPREAIYENLCRGCGYGVFAAQGRYCHFCQCIVSGGVVSTPPPPPPPPLSTISGESSNIYENICDLCRGIYSDNERCRCQRSETPAKAPAPSTPTTPPTPPTKVKSRSLLGYSKSSAATLTRLFGSLKQLNRSSSLQRRIFPRTPTTGSSSAGSLEIIHNVDEVFRTQETFDLQRICELKLEQQQLKGSQSDQHIYGRVREPEESQSHKRERKRPRVSRIRLLQDESTSGSSSLYLNESICQWMTSLRRQVHHYDEGPWQQPKSVPARDPSSSAEESTVTLRRSTEESAKCADEQAKLVKDFKRKLQQKRAHNVEPEREQRRCAITANFVNDYLSALGEEKEAVQHQQVAAIEEHVAVVAIAIQPQVSVSLLRLMQSLALSASLHVSVRGFLTAYDKSFSLWLWHQQQQQRQQPPINGYRRRRARDSVVGVVGDWRRRLPLFAFSFAGGNDRSVASASVSVSPAISESVDVCAAAASRRRANRSTRRRGTAIVREEGVCGGESSTSSNNSKKNNNNNSNNNSGALMAAPKPNGEAERPSTNSNNNTINCSSNNNNDNISNNNNNHHTVDNESGINNNKNNDGNANCNVNEQQQQQQQQPITQNCVIKVRRPAPKVPVRNPNTSLSNPRQIEEEQTKPNGGKKDNLRGNSFAAENSSPEEQEEESIYQPIWQFKTIEPVDQEIIEALPVEGEDEEDEDEEDDDVDDEEEDLGDYDESLPSDADPDVMALQAAAVFAAGVRHKLSTSTLTKRSKMMMPTPLPSPTASMDHGAWETDMEFMYSRESKEEADETLSLGSTVTNSTATLGSISSTGSSVTGQPKDTPKDLPADQQPSVVVHPILRNICIFYSQKDPKKYSAIFYDYHLSLVHQRFMTRIRRPAPPPPAQLATSNTTSLAPRSDDSGCSCEAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRGVAPRTGRKLRVRSNARLLLTDSVLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTILQRYKSVSIGNLLDLPGEDDKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRSRRGQVNSLYLDEQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQLDIGRMNMLAKVLIENYDRIFHPDNERLVC
Protein: Synaptonemal complex protein ZEP1 (Q7FAD5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Required for chromosome synapsis and regulates crossover frequency during meiosis. Acts as transverse filament protein and constitutes the central element of the synaptonemal complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:20154151, ECO:0000269|PubMed:22393242}. Chromosome {ECO:0000269|PubMed:20154151, ECO:0000269|PubMed:22393242, ECO:0000269|PubMed:27436711}. Note=During zygotene in meiocytes, initially localizes onto the chromosomes as punctate foci and quickly extends into linear signals (PubMed:20154151, PubMed:22393242). Associates with chromosomal axes at zygotene (PubMed:27436711). {ECO:0000269|PubMed:20154151, ECO:0000269|PubMed:22393242, ECO:0000269|PubMed:27436711}.
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase
- DNA-directed RNA polymerase
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta''
- Meiosis-specific protein PAIR2
- Meiosis-specific protein PAIR3
Sequence:
MQKLGLSGLRGLEGFRSLAGSTSTAAKAPNPKPSSDIGGSTYGSFANLKITAEKLVKEQASVKTDLEMTHTKLRRATEQINLLEAKLQQAVNENAKLKVKQTEDSKLWQGLDSKVSSTKTLCNQLTETLQQLASQTERAEEDKKFFEEILGKNSKAFEEFNCLLHDSSIKLECAEQMIISGKQEMLRIKQEKEEMDQSYKEQLYASDTTIREKNSLIKQLEDSIEQNKARLLYVDSRLECMEQELKLKEDVCICLKENLASTESEKNDLKLRNEGYTLEVQKLSKDNKELNELLSGFTVKVTELDKEHTSISSHVTQLISSFERYDGKVHEEKMLMIKSAKDKFEHLQNQYVNLISENNALQTEIEELKSRIIELQKTQEIVMVQHVEECQVAEDKIRRLESEAEISASNISQLEKVASDLEGRVQKLLEDSRSAENHKQELLQKILKLESDNQELLGRVQSVLNEKSNDTESLQGEIAKRDQQVETLENQVNQLCSIIDEKEQLHTCAVEREKNLEEQKLQVQASLAATESQLTEAKKQYDIMLEGKKIELSKHLKELSLKNDQAINEIRRKYELEKVEIINIEKEKAEKLIKEMENKCNEKISENRQDSERYLMCLKEEHGSMVARIQQDNEHKESTLRAYHKEELQRIQSQAENELRERLSSLRKDHEIQMKSLTKKHEENCQKLQDELELQKSKEEKQRALLQLQWKVMGETQQVDQEVNSKKEYSVSSIKRRDPYIRKEHQLQLVSPETKRKDVNLSGIIQSPITNMLRKVEKGTQDIPKHRKVTHHEYEVETANGRITKRRKTKSTVMFGEPNTQKSLHDTADKDPTKMKKVVAGSHPHPANIGELFSEGSLNPYAEDPYAFG
Protein: ADP-ribosylation factor 1-like 1 (EC 3.6.5.2) (ADP-ribosylation factor-like protein 6) (ADP-ribosylation factor-related protein 1.1) (Q94231)
Organism: Caenorhabditis elegans
Function: Small GTPase involved in protein trafficking between different compartments (By similarity). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:P84077}; Lipid-anchor {ECO:0000250|UniProtKB:P84077}; Cytoplasmic side {ECO:0000305}. Note=In the GDP-bound form, associates transiently with the membranes via its myristoylated N-terminus where guanine nucleotide-exchange factor (GEF)-mediated nucleotide exchange occurs (By similarity). Following nucleotide exchange, the GTP-bound form undergoes a conformational change, leading to the exposure of a myristoylated N-terminal amphipathic helix that provides stable membrane anchorage (By similarity). {ECO:0000250|UniProtKB:P84080}.
Interaction partners:
- AP-1 complex subunit gamma
- Phosphatidylinositol 4-kinase beta
- MHD domain-containing protein
- AP-1 complex subunit mu-1-I
- Probable coatomer subunit gamma
- AP complex subunit beta
- Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog
- ADP-ribosylation factor GTPase-activating protein 1
- Coatomer subunit beta
- Probable coatomer subunit zeta
Sequence:
MGLFFSKISSFMFPNIECRTLMLGLDGAGKTTILYKLKLNETVNTIPTIGFNVETVTFQKITLTVWDVGGQKKIRALWKYYFPNTTTLVFVVDSSDIERIPEAKEELFSLLAEPELADSHLLVFANKQDMPNARSPAELTQLLDLGSLKNREWFICGTNAHSGQGLYEGLMWVKKQMKT
Protein: Peroxiredoxin Asp f3 (Prx) (EC 1.11.1.24) (Thioredoxin peroxidase) (TPx) (Thioredoxin-dependent peroxiredoxin) (allergen Asp f 3) (O43099)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Required for virulence.
Interaction partners:
- Thioredoxin peroxidase
- Superoxide dismutase, mitochondrial
- Crh-like protein 5
- Ribonuclease mitogillin
- Allergen Asp f 4
- Major allergen Asp f 2
- Large ribosomal subunit protein P2
- Thioredoxin domain protein
Sequence:
MSGLKAGDSFPSDVVFSYIPWSEDKGEITACGIPINYNASKEWADKKVILFALPGAFTPVCSARHVPEYIEKLPEIRAKGVDVVAVLAYNDAYVMSAWGKANQVTGDDILFLSDPDARFSKSIGWADEEGRTKRYALVIDHGKITYAALEPAKNHLEFSSAETVLKHL
Protein: G3BP stress granule assembly factor 1 (Ras GTPase-activating protein-binding protein 1) (E5RJU8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000256|ARBA:ARBA00004331}.
Interaction partners:
Sequence:
MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEVHLALFLAQSLFLNQLFLQGGLVLFSYTYERTTSLC
Protein: Cytochrome P450 83A1 (EC 1.14.14.43) (CYPLXXXIII) (Protein REDUCED EPIDERMAL FLUORESCENCE 2) (P48421)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the metabolism of aliphatic and aromatic oximes. Involved in the biosynthesis of both short-chain and long-chain aliphatic glucosinolates.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Methionine aminotransferase BCAT4
- Methylthioalkylmalate synthase 1, chloroplastic
- Transcription factor MYB28
- Methylthioalkylmalate synthase 3, chloroplastic
- S-alkyl-thiohydroximate lyase SUR1
- Cytosolic sulfotransferase 18
- Cytosolic sulfotransferase 17
- Flavin-containing monooxygenase FMO GS-OX1
- UDP-glycosyltransferase 74C1
- UDP-glycosyltransferase 74B1
Sequence:
MEDIIIGVVALAAVLLFFLYQKPKTKRYKLPPGPSPLPVIGNLLQLQKLNPQRFFAGWAKKYGPILSYRIGSRTMVVISSAELAKELLKTQDVNFADRPPHRGHEFISYGRRDMALNHYTPYYREIRKMGMNHLFSPTRVATFKHVREEEARRMMDKINKAADKSEVVDISELMLTFTNSVVCRQAFGKKYNEDGEEMKRFIKILYGTQSVLGKIFFSDFFPYCGFLDDLSGLTAYMKECFERQDTYIQEVVNETLDPKRVKPETESMIDLLMGIYKEQPFASEFTVDNVKAVILDIVVAGTDTAAAAVVWGMTYLMKYPQVLKKAQAEVREYMKEKGSTFVTEDDVKNLPYFRALVKETLRIEPVIPLLIPRACIQDTKIAGYDIPAGTTVNVNAWAVSRDEKEWGPNPDEFRPERFLEKEVDFKGTDYEFIPFGSGRRMCPGMRLGAAMLEVPYANLLLSFNFKLPNGMKPDDINMDVMTGLAMHKSQHLKLVPEKVNKY
Protein: Beta-amylase 6 (EC 3.2.1.2) (1,4-alpha-D-glucan maltohydrolase) (Beta-amylase 5) (Q8L762)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic
- 4-alpha-glucanotransferase DPE2
- alpha-D-xyloside xylohydrolase
- Isoamylase 3, chloroplastic
- Alpha-amylase 3, chloroplastic
- Probable alpha-amylase 2
- Alpha-amylase 1
- Alpha-glucan phosphorylase 2, cytosolic
- Phosphoglucan phosphatase LSF1, chloroplastic
- Alpha-glucan water dikinase 2
Sequence:
MTSVLGMMNPNLINGRNLHKGSSIFVQDKETKKRVQWRLSIKEGSLRTHQATASSATEPKATEFNTTTYEDKMLTNYVPVYVMLQLGVITNDNVLENEESLKKQLKKLKQSQVDGVMVDVWWGIVESKGPKQYQWSAYRNLFAIVQSFGLKLQAIMSFHRCGGNIGDDVNIPIPKWVLEIGDSNPDIFYTNKSGNRNKECLSLSVDNLSLFRGRTAVEMYRDYMKSFRENMEDFISSGVIIDIEVGLGPAGELRYPSYSETQGWVFPGIGEFQCYDKYLRSDYEEEVRRIGHPEWKLPENAGEYNSVPGETEFFEYSNGTYLKEEGNFFLSWYSKKLLLHGDQILDEANKVFLGCKLKIAAKVSGIHWWYKTESHAAELTAGYYNLKNRDGYRAIAKIMRRHHAILNFTCLEMKNTEQPAKAKSGPQELVQQVLSSGWREGIEVAGENALPRFDRNGYNQIILNARPNGVNQDGKPRMFGFTYLRLSDKLLNEPNFSTFKMFLKRMHANQEYCSEPERYNHELLPLERSRNDESLEMFMEETEPFDPFPWLDETDMSIRPFESVLSLLRSTFLRKKS
Protein: Sr protein (Q26452)
Organism: Drosophila sp. (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
QQQQHQQQPLHQQQQLQHQQQQQHHQQHYQQHATIQHQQSQQQASKISYRGIFTTTGNAMNAAAAAAAAAAQQQHQQQQQHQQQLPSPQLGVLAGPMSPPSNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQAAGAAPSPYDDGRAAAAAAAQHAELLGLTMDGTPLLLKQPPPSYAGASAGFPGLGDLHSSHEQQLQQQQYVRSQPKYQWLDSPADYAQQQQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGVLIPKQENYPDMQPSSNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQSTVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQRIKKEKVRGEQQQQQQQQQQQQQQQQQLQQQQEQHHLSLQQHQQYQQHHLLHSADLAIVTSSASM
Protein: N-alpha-acetyltransferase 20 (EC 2.3.1.254) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB catalytic subunit) (M9PI14)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Phagocyte signaling-impaired protein
- N
- Probable N-acetyltransferase san
- N-alpha-acetyltransferase 35, NatC auxiliary subunit homolog
- N-terminal amino-acid N
- N-alpha-acetyltransferase 40
- N
- N-alpha-acetyltransferase 80
- N-alpha-acetyltransferase 30A
Sequence:
MTTLRPFTCDDLFKFNNVNFDPLTETYGLSFYTQYLAKWPEYFQLAESPSGQIMGYIMGKVEGHLDNWHGHVTALTVSPDYRRLGLAALLMSFLEDISEKKRAYFVDLFVRKSNQVAINMYTNLGYIIYRTILEYYSGDQDEDAYDMRKALSRDVNKKSVIPYTQPITMRELRRQMRHDH
Protein: Translation initiation factor eIF2 assembly protein (Q9M0V1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR007807}.
Interaction partners:
- protein-synthesizing GTPase
- Tocopherol cyclase, chloroplastic
- protein-synthesizing GTPase
- protein-synthesizing GTPase
- Protein-lysine N-methyltransferase At1g66680
- Eukaryotic translation initiation factor 2 subunit beta
- Eukaryotic translation initiation factor 2 subunit beta
- Eukaryotic translation initiation factor 2 subunit beta
- Probable ubiquitin-conjugating enzyme E2 31
- Chaperone protein dnaJ GFA2, mitochondrial
Sequence:
MKEDEVNRCQIQNWYPRFKSLTIKTKFHKLPESFINYLIDDSGPFLLPHSVTNEDAMPNRVHNFEEEDDFQVPEEASDDEPLNRPSFPELEIEIRESIETLGGTIIPKLNWSSPKDAAWISPSQNLSCTCFNEIALLFRSSDSLTHDLFNAYDSCSDKVSSRPESFYLALRKWYPSLKPEMEFRCFVKSNELVGICQREVTTFYPVLLNEKDLLKGLIEEFFDDKIRFEFESENYTFDVYVTKERRVKLIDFNTWCGSTLPLMYTWEELEKIHGECDELELRIVESRLSVLPGLKTAVPYDYLDVSAGSGWAQVLKIVEEEFQKDDQSSDEVA
Protein: 3-hydroxyacyl-CoA dehydrogenase NAD binding domain-containing protein (Q19660)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSSIVVGSGVLAETVVGLLCAAGRRVSLVAPSGKVNALKFDSSVIKAILQEDSEKKIPFEFIDDIRQQQKLADKNFKKINVTTDISKIEAADQIIDACSADESSLFINTAKAVPNATIISLNGEKSPIHSNHVSVKMYSPIHETKTAKMFTNSKVSKKTLEEVNQLLDSMGLTVLSEEDSRVADRLVLDMQQVEKSSSLSKLISTLVTPLNAPATPSMPKEQYLLF
Protein: KRR1 small subunit processome component homolog (KRR-R motif-containing protein 1) (Protein dribble) (Q9VPU8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Binds to RNA. Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11359931}. Note=Exogenous expression in embryos shows a predominant localization in nucleoplasm in some epidermal cells while most other cells show perinucleolar ring structure. In heat-shocked third instar larvae, localization varies among cells. In gut cells, some show localization in both nucleoplasm and nucleolus while in others localization is restricted to the center of the fibrillarin-positive part of the nucleolus, in the fibrillar center, where rRNA transcription occurs. On ectopic expression, a nuclear engrailed pattern is observed in embryonic epidermal cells. {ECO:0000269|PubMed:11359931}.
Interaction partners:
- Nucleolar protein 10
- Uncharacterized protein
- Probable U3 small nucleolar RNA-associated protein 11
- Bystin
- LD41718p
- LD38375p
- U3 small nucleolar RNA-associated protein 18 homolog
- LD47749p
- rRNA biogenesis protein RRP5
- GH01043p
Sequence:
MSESEAEETKISTEPVDNAWSMKIPAFRQEDNPHGMVEESSFATLFPKYRERYLKEVWPLVEQCLAEHHLKAELDLMEGSMVVKTSRKTWDPYIIIKARDMIKLMARSVPFEQAKRVLQDDIGCDIIKIGNLVHKKEKFVKRRQRLIGPNGATLKSIELLTDCYVLVQGNTVSALGPYKGLQQVRDIVLETMNNVHPIYNIKALMIKRELMKDPRLANEDWSRFLPKFKNKNISKRKQPKVKKQKKEYTPFPPSQPESKVDKQLASGEYFLNQEQKQAKRNQERTEKQKEAAKRQDERRNKDFVPPTEESAASSRKKEDGSSSSKVDVKALKAKLIKANKKARSS
Protein: Uncharacterized GPI-anchored protein At1g61900 (Q8GUI4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Uncharacterized GPI-anchored protein At3g06035
- AT5g08500/MAH20_6
- Mannan endo-1,4-beta-mannosidase 6
- Cleft lip and palate associated transmembrane protein-like
- Nuclear pore complex protein GP210
Sequence:
MTRRAEFEMGLFVILQSMFLISLCSSQKPEEFLPEISPDTSPQPFLPFIAPSPMVPYINSTMPKLSGLCSLNFSASESLIQTTSHNCWTVFAPLLANVMCCPQLDATLTIILGKASKETGLLALNRTQSKHCLSDLEQILVGKGASGQLNKICSIHSSNLTSSSCPVINVDEFESTVDTAKLLLACEKIDPVKECCEEACQNAILDAATNISLKASETLTDNSDRINDCKNVVNRWLATKLDPSRVKETLRGLANCKINRVCPLVFPHMKHIGGNCSNELSNQTGCCRAMESYVSHLQKQTLITNLQALDCATSLGTKLQKLNITKNIFSVCHISLKDFSLQVGNQESGCLLPSLPSDAIFDKDTGISFTCDLNDNIPAPWPSSSLSSASTCKKPVRIPALPAAASSQPRLHDEGVTRLVIFVLSMLLVMLLS
Protein: MIP20649p (Multiplexin, isoform P) (D5AEK4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRFDLQSKNLLNSPPPLLNTPTLRVAALNEPSTGDLQGIRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADRDLPVVNTRGDVLFNSWKGIFNGQGGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSMDTYCDAWHSGDHLKGSFASNLDGHKLLEQKRQSCDSKLIILCVEALSQDRKRKKREIGDGSSHGESESREFKTADEYAAHLENLLL
Protein: AT4g27600/T29A15_90 (PfkB-like carbohydrate kinase family protein) (Q940Y6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pentatricopeptide repeat-containing protein At4g25270
- Thioredoxin-like fold domain-containing protein MRL7, chloroplastic
- Protein PLASTID REDOX INSENSITIVE 2
- Ribokinase
- Ketose-bisphosphate aldolase class-II family protein
- Pentatricopeptide repeat-containing protein At1g15510, chloroplastic
- Pentatricopeptide repeat-containing protein At4g18520, chloroplastic
- N6-mAMP deaminase
Sequence:
MAFSLLSPIPTSASLFFTLSAITASNNASSSSLSRLYSLYHPKGTLRTRTATSFFGASGNLRIVSMAENRQLVCRIGGGAGAELDDMDEGEIQRIGNEDEDDDEFIQVHANNSSAASPERWDVLGLGQAMVDFSGVVDDEFLKKLGLEKGTRKLINHEERGKLLQAMDGCSYKAAAGGSLSNTLVALARLGSQSICDRPLNVAMAGSIGGDPLGSFYGTKLRRANVNFLSAPIKDGTTGTVIVLTTPDAQRTMLAYQGTSSVVNYDSCLASLIAKTNVFVVEGYLFELPDTIRTITKACEEAHRNGALVAVTASDVSCIERHYDDFWDIVGNYADIVFANSDEARAFCHFSAEESPISATRYMSHFVPFVSVTDGINGSYIGVKGEAIYIPPSPCVPVDTCGAGDAYASGILYGILRGVSDLKGMGDMAATIAATVVGQQGTRLRVQDAVELARSHAFRLNGSGVRTDVGS
Protein: Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6) (P24592)
Organism: Homo sapiens (Human)
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
Subcellular location: Secreted {ECO:0000305|PubMed:24003225}.
Interaction partners:
- Insulin-like growth factor 2
- Insulin-like growth factor 1
- Insulin-like growth factor-binding protein 1
- Insulin-like growth factor-binding protein complex acid labile subunit
- Sterol O-acyltransferase 2
- Insulin-like growth factor-binding protein 3
- Insulin
- Insulin-like growth factor 1 receptor
- Insulin-like growth factor-binding protein 5
- Insulin-like growth factor-binding protein 7
Sequence:
MTPHRLLPPLLLLLALLLAASPGGALARCPGCGQGVQAGCPGGCVEEEDGGSPAEGCAEAEGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLPARAPAVAEENPKESKPQAGTARPQDVNRRDQQRNPGTSTTPSQPNSAGVQDTEMGPCRRHLDSVLQQLQTEVYRGAQTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGKSLPGSPDGNGSSSCPTGSSG