wanglab/gogpt-training-data huggingface dataset:
Protein: RNA-binding protein FXR1 (FXR1P) (mFxr1p) (Q61584)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs.
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:22022532, ECO:0000269|PubMed:35951695}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P51114}. Cytoplasm {ECO:0000305|PubMed:30770808}. Cell projection, dendrite {ECO:0000269|PubMed:22022532}. Cell projection, dendritic spine {ECO:0000269|PubMed:22022532}. Cell projection, axon {ECO:0000269|PubMed:22022532}. Nucleus envelope {ECO:0000250|UniProtKB:P51114}. Postsynapse {ECO:0000269|PubMed:27770568}. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (PubMed:35951695). Localizes to stress granules following phosphorylation at Ser-449 by PAK1 (By similarity). Adjacent to Z-lines in muscles (PubMed:30770808). {ECO:0000250|UniProtKB:P51114, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:35951695}.
Interaction partners:
- Cytoplasmic FMR1-interacting protein 1
- Cytoplasmic FMR1-interacting protein 2
- Protein argonaute-2
- RNA-binding protein FXR2
- Fragile X messenger ribonucleoprotein 1
- FMR1-interacting protein NUFIP1
- Ras GTPase-activating protein-binding protein 1
- Transcriptional activator protein Pur-alpha
- Cytoplasmic polyadenylation element-binding protein 1
- Endoribonuclease Dicer
Sequence:
MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESAEAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSTRGPEREKGYATDESTVSSVQGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRETRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGLTESDTASVNENGLDDSEKKPQRRNRSRRRRFRGQAEDRQPVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDEIPKLPRTLGEEKTKTLKEDSTQEAAVLNGVS
Protein: Pre-mRNA-splicing factor 38 (Q57XW0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367025}.
Interaction partners:
Sequence:
MVEPHLFCGPEFTLEVPSELPLPVEPNILLQLQSELYNLLTPLVRHKLHATWGTGTGSCDGTVPPPPCELCFVEVVESSPVPDPGARENEKDNVSNEKNEATAKLVLRIKDSRAASELFVIGLRNPFITLPHGIRLHNRCGGSAVGTAKARATPVEILRKKELLRSRMNFDEDLWELLQGSLTSEWLLALEETYKQHKQQQSSNHEAVTSLRESQRHERRVESLLHYCEQNVLYIGVMDEEGKATPFLLAIGAFYKLGLTRHDALVHFARHHRRTIRALALFIARYTTAPEELEPFFTPSLTDEVVVACAEDQQVTCSMRQLAEDLLLHDEVCEAWPPTLHPFWIEHTVRPMMLRVEADRKRREELFQERESGVATEKEQGNRTGSGSSAPGGSGKGVGVFGFCNIMELHAYVREKQRVLVPQRVLSMLSKPRGGDSGDRDYADDGDDDDDDFLIKVRVEGDGDAEQNALHHQNKRGIDTKQPKQGQQQLSVRQGDSRKRRRQGTTTARSLAVTGAYRTILTLLGRTEPFDPHCEHFLQF
Protein: 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA) (Tat-binding protein 1) (TBP-1) (Q63569)
Organism: Rattus norvegicus (Rat)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000250|UniProtKB:O88685}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome non-ATPase regulatory subunit 11
- Proteasome
- 26S proteasome regulatory subunit 4
- Proteasome subunit alpha type-5
- Proteasome
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 6
- Proteasome subunit alpha type-1
Sequence:
MNLLPTPESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIVQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
Protein: Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) (Q3B7D0)
Organism: Rattus norvegicus (Rat)
Function: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:666752}.
Interaction partners:
- Amine oxidase
- Uroporphyrinogen decarboxylase
- Ferrochelatase
- Uroporphyrinogen-III synthase
- Delta-aminolevulinic acid dehydratase
- Porphobilinogen deaminase
- 5-aminolevulinate synthase, non-specific, mitochondrial
- Endonuclease V
- 5-aminolevulinate synthase, erythroid-specific, mitochondrial
- Heme oxygenase 2
Sequence:
MALRLGQLGSGPWWRAVRGDYAQLRAPSPRSASACVCRLPGTAGTQPRRGLGHGSSAGGGSRLGTGLAAALAGMAGLAAAVLGHVQRAEMVPKSSGARSPSPGRLEEDGDELARRCSTFMSSPVTELRELGRRPDDMKTKMELMIMETQAQVCRALAQVDGVADFSVDRWERKEGGGGITCVLQDGRVFEKAGVNISVVHGNLSEEAANQMRSRGKALKKKDGKLPFTAMGISSVIHPKNPYAPTMHFNYRYFEVEEADGKMHWWFGGGCDLTPTYLNREDAVHFHRTLKEACDQHGPDIYPKFKKWCDDYFFIAHRGERRGIGGIFFDDLDSPSKEEAFRFVKTCAEAVVPSYVPIVKKHCDDSYTPQDKLWQQLRRGRYVEFNLVYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPPENSKEAEILEVLRHPKDWVH
Protein: Protein lin-7 homolog C (Lin-7C) (Q5F425)
Organism: Gallus gallus (Chicken)
Function: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains (By similarity). The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction {ECO:0000250}.
Interaction partners:
- Calcium/calmodulin dependent serine protein kinase
- Coiled-coil domain containing 34
- Adenylyltransferase and sulfurtransferase MOCS3
- Stomatin like 3
- 55 kDa erythrocyte membrane protein
- PHB domain-containing protein.
Sequence:
MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKRRQQN
Protein: Gibberellic acid methyltransferase 1 (Gibberellin A(9) O-methyltransferase) (EC 2.1.1.275) (F4JUY5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methylates the carboxyl group of several gibberellins (GAs). Substrate preference is GA9 > GA20 > GA3 > GA4 > GA34 > GA51 > GA1 > GA19 > GA12. No activity with diterpenes abietic acid and ent-kaurenoic acid.
Interaction partners:
- Cytochrome P450 714A2
- Cytochrome P450, family 72, subfamily A, polypeptide 10
- Cytochrome P450
- Cytochrome P450 72A11
- Cytochrome P450, family 72, subfamily A, polypeptide 9
- Cytochrome P450 714A1
- Cytochrome P450 72A14
Sequence:
MESSRSLEHVLSMQGGEDDASYVKNCYGPAARLALSKPMLTTAINSIKLTEGCSSHLKIADLGCAIGDNTFSTVETVVEVLGKKLAVIDGGTEPEMEFEVFFSDLSSNDFNALFRSLDEKVNGSSRKYFAAGVPGSFYKRLFPKGELHVVVTMSALQWLSQVPEKVMEKGSKSWNKGGVWIEGAEKEVVEAYAEQADKDLVEFLKCRKEEIVVGGVLFMLMGGRPSGSVNQIGDPDSSLKHPFTTLMDQAWQDLVDEGLIEEEKRDGFNIPVYFRTTEEIAAAIDRCGGFKIEKTENLIIADHMNGKQEELMKDPDSYGRDRANYAQAGLKPIVQAYLGPDLTHKLFKRYAVRAAADKEILNNCFYHMIAVSAVRV
Protein: Sulfolipid-1 exporter MmpL8 (P9WJU5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Required for the biosynthesis and the transport across the inner membrane of sulfolipid-1 (SL-1), which is a major cell wall lipid of pathogenic mycobacteria. Could also transport SL1278 (2-palmitoyl-3-(C43)-phthioceranyl-alpha, alpha'-D-trehalose-2'-sulfate), which is the precursor of SL-1. Required for virulence.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:22194604}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- 2'-acyl-2-O-sulfo-trehalose
- Phthioceranic/hydroxyphthioceranic acid synthase
- Acyltransferase PapA3-trehalose mycolipenoyltransferase)
- Trehalose-2-sulfate acyltransferase PapA2
- Acyltrehalose exporter MmpL10
- Mycolipanoate synthase
Sequence:
MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPWVVIAFWVALAGLLAPTVPSLDAISQRHPVAILPSDAPVLVSTRQMTAAFREAGLQSVAVVVLSDAKGLGAADERSYKELVDALRRDTRDVVMLQDFVTTPPLRELMTSKDNQAWILPVGLPGDLGSTQSKQAYARVADIVEHQVAGSTLTANLTGPAATVADLNLTGQRDRSRIEFAITILLLVILLIIYGNPITMVLPLITIGMSVVVAQRLVAIAGLAGLGIANQSIIFMSGMMVGAGTDYAVFLISRYHDYLRQGADSDQAVKKALTSIGKVIAASAATVAITFLGMVFTQLGILKTVGPMLGISVAVVFFAAVTLLPALMVLTGRRGWIAPRRDLTRRFWRSSGVHIVRRPKTHLLASALVLVILAGCAGLARYNYDDRKTLPASVESSIGYAALDKHFPSNLIIPEYLFIQSSTDLRTPKALADLEQMVQRVSQVPGVAMVRGITRPAGRSLEQARTSWQAGEVGSKLDEGSKQIAVHTGDIDKLAGGANLMASKLGDVRAQVNRAISTVGGLIDALAYLQDLLGGNRVLGELEGAEKLIGSMRALGDTIDADASFVANNTEWASPVLGALDSSPMCTADPACASARTELQRLVTARDDGTLAKISELARQLQATRAVQTLAATVSGLRGALATVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGSRQLAEGVQLLVDQVKKMGFGLGEASAFLLAMKDTATTPAMAGFYIPPELLSYATGESVKAETMPSEYRDLLGGLNVDQLKKVAAAFISPDGHSIRYLIQTDLNPFSTAAMDQIDAITAAARGAQPNTALADAKVSVVGLPVVLKDTRDYSDHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLIGSVIVSYLAALGIGVIVFQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLGVRSGVIRTVASTGGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVRTVTVPAIAVLVGQANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEEEEQSPPDDDDLIGLWLHDGLRL
Protein: Transcriptional activator protein rdp1 (Rhp51-DRE-binding protein 1) (O13862)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a DNA damage-response activator of rhp51. Binds to part of the DNA damage-responsive element (DRE), (5'-NG[GT]T[GA]-3').
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSEHSPEASSTYAQVTSNDELSSNKIYMNADQNNSRKKEMDGSLQNNGGRLQNVNPLGGNESMSAVATSAASSLPTAENGVSLNAASPTIHSNTPTVVSHPVMSGSELKGEESHNSPGTLNGTSVANASKQPNMPNATFRCDKCDMMFVKQSGLTNHKRTYHQVETVVIIGHRRYVWRRNENGRFQCVCGRQNWRRPVNFASHAKQCPSFLAMDPNNIPPEINKVSPHDDLRPLSDSRRRARRPHPSDTIPPGASMARSDPSQVPESNPSAAAAVAAAAVAAAANLTNGVNPPEVPRNLNSSLVDAAESLANVSQQQHHRHPFARQPDYSAHSIPRTAAPYAPSMNMFAQNGPNTSLLPTAMPSDVSISSSLQQQPIHPSYDSRFSKAPQGTDALAALGYGTPSSAATLCPLYRDTPAAIVSEKLHLRLANLRIAYCEDCREFISLNAALDHRRSHHQQNITGDLVHVYSDFLDFQNC
Protein: Ribosome biogenesis protein RLP7 (Ribosomal protein L7-like) (P40693)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11087857}.
Interaction partners:
- rRNA-processing protein EBP2
- Nucleolar complex protein 2
- 25S rRNA
- Pescadillo homolog
- Ribosome biogenesis protein 15
- ATP-dependent RNA helicase HAS1
- Ribosome biogenesis protein RPF2
- ATP-dependent rRNA helicase SPB4
- Periodic tryptophan protein 2
- Regulator of ribosome biosynthesis
Sequence:
MSSTQDSKAQTLNSNPEILLRKRRNADRTRIERQELAKKKREEQIKKKRSNKNKFVRAESIVAKTLATSREKERIKRVSILEDKKAKNETQHIASGKDFILKITEKANGAEENSVDLEETEEEEDDGLIREKTTYDGKPALLFIVRVRGPLAVNIPNKAFKILSLLRLVETNTGVFVKLTKNVYPLLKVIAPYVVIGKPSLSSIRSLIQKRGRIIYKGENEAEPHEIVLNDNNIVEEQLGDHGIICVEDIIHEIATMGESFSVCNFFLQPFKLNREVSGFGSLNRLRKIKQREAESRTRQFSNAATAPVIEVDIDSLLAKLN
Protein: Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha) (E9Q7X7)
Organism: Mus musculus (Mouse)
Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
Subcellular location: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9CS84}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Neuroligin-1
- Neuroligin-3
- Neuroligin-2
- Dystroglycan 1
- Leucine-rich repeat transmembrane neuronal protein 2
- Cerebellin-1
- Peripheral plasma membrane protein CASK
- Disks large homolog 4
- Glutamate receptor ionotropic, delta-2
- Neurexin-1
Sequence:
MALGSRWQPPPQLPPLLLLLALAAGVRGLEFGGGPGQWARYARWAGAASTGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGAAADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGAGVGSHSSTQRADYFAMELLDGYLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGESEVLDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGICREGWNRFVCDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPTAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMRLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHTRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTMRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPSSGGPCQAERDDSDCEEPVEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGVPTAFEPRRPPPLRPGVTSAPGFPRLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
Protein: Aquaporin PIP1-1 (AtPIP1;1) (Plasma membrane aquaporin-1) (Plasma membrane intrinsic protein 1a) (PIP1a) (P61837)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Water channel required to facilitate the transport of water across cell membrane. Its function is impaired by Hg(2+).
Subcellular location: Cell membrane {ECO:0000269|PubMed:7920711}; Multi-pass membrane protein {ECO:0000269|PubMed:7920711}.
Interaction partners:
- PAMP-induced secreted peptide 1
- Aquaporin PIP2-3
Sequence:
MEGKEEDVRVGANKFPERQPIGTSAQSDKDYKEPPPAPFFEPGELSSWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRALYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKDHSWDDHWVFWVGPFIGAALAALYHVVVIRAIPFKSRS
Protein: Probable purine permease 10 (AtPUP10) (O49725)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Embryo defective 2737
- Early nodulin-like protein 1
- Ethylene-responsive transcription factor ERF069
Sequence:
MTADQELQIIVRQGKEPNPTVQDERNSVSSSQAEVSHSNTYKRWLRVTLYTFFVISGQTVATILGRVYYDNGGNSKWLATVVQLVGFPVLLPYYILSFKTHATTDRDGKRTSPRNRVLVYVVLGLLVGADCYLYSIGLLYLPVSTYSLICASQLAFNAFFSYFLNSQKLTPIILNSLFLLTISSTLLAFNNEETDSTKVTKGEYVKGFICTVAASAGYGLVLSLQQLAFLKVLKKQNFSEVMDMIIYVSLVASCVSVVGLFASSEWKTLSSEMDNYKHGKVSYIMNLVWTAVTWQVFSIGGTGLIFELSSLFSNAISVLGLPVVPILAVIIFHDKMNGLKVISMILAIWGFTSYVYQQYLDDKNLKKNHEITTTESPDPPEAEESTWQSK
Protein: tRNA wybutosine-synthesizing protein 3 (tRNA-yW-synthesizing protein 3) (EC 2.1.1.282) (tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase) (Q9UTA5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72 (By similarity).
Interaction partners:
- tRNA wybutosine-synthesizing protein 4
- tRNA wybutosine-synthesizing protein 2
- S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
- tRNA
- Large ribosomal subunit protein mL49
- Uncharacterized protein C3F10.06c
- Multisubstrate pseudouridine synthase 7
Sequence:
MNIKGIDVSFDAQKKEILEGLKSSVPDASPKGHPDSPIFPLLDVINSHPDWVTTSSCSGRISVYVQGANSRKGGGYWLFVSHQAHEELPPVLEDEKVEYGKVPSSPVEGNREIQYAFEPMILHVQTRSLANAQHLQRVAASCGFRETGIQGSEQKFIVAIRTSLRMDIPIGCLTASEKLQFYITREYMCFLFKRSVEYFTENGNRMARLKEQLERQVEKRMKPRRKLRNMDDYLVQS
Protein: E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase listerin) (H7BYG8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLGYVPAIQGAEEIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQPEAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLPDNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPSVLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIYPYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIMQQNLGEEEIEQMLVNDQLIPFIDAVLKDPGLQHGQLFNHLAETLSSWEAKADTEKDEKTAHNLENVLIHFWERLSEICVAKISEPEADVESVLGVSNLLQVLQKPKSSLKSSKKKNGKVRFADEILESNKENEKCVSSEGEKIEGWELTTEPSLTHNSSGLLSPLRKKPLEDLVCKLADISINYVNERKSEQHLRFLSTLLDSFSSSRVFKMLLGDEKQSIVQAKPLEIAKLVQKNPAVQFLYQKLIGWLNEDQRKDFGFLVDILYSALRCCDNDMERKKVLDDLTKVDLKWNSLLKIIEKECTCREVQILTSVWKKILFLSSDWKFLASVCCLRFHDSLASSSPYS
Protein: Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (N-acylsphingosine amidohydrolase 2) (znCD) (Q5W7F1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (By similarity). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity).
Subcellular location: [Neutral ceramidase]: Cell membrane {ECO:0000269|PubMed:15271994}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Membrane raft {ECO:0000250|UniProtKB:Q9JHE3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Membrane, caveola {ECO:0000250|UniProtKB:Q9JHE3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NR71}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Mitochondrion {ECO:0000250|UniProtKB:Q9NR71}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:Q9NR71}.
Interaction partners:
- Alkaline ceramidase
- Alkaline ceramidase 1
- Acid ceramidase
- Ceramide kinase
- Ceramide kinase family protein
- Sphingosine kinase 2.
- N-acylsphingosine amidohydrolase
- Sphingosine kinase 1.
- 3-dehydrosphinganine reductase
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
Sequence:
MASKSRRLSGLEISLIVLFLLMTAVSVALITVLALKQESDKKEEVTPEEPSPSVTPPEKPYLIGVGRADCTGPVADLPMMGYANTDQTARGLHTRLFSRAFIVDDGNKRVVFVTSDIGMVSQRLRLEVFQALKEKYGDLYRQDNVVLSGTHTHSGVGGYFQYTLFMITSKGYIKPSIQAIVSGIVKSIDIAHRNLRPGRIFINKGQVADSNFNRSPHSYMNNPEEERNRYEFNTDKQIVVLKFTDLDGDGIGLLSWFAVHPVSMNYTNRMVSSDNLGYASYIFEQEKNIGFLPGEKGPFVAGFSSSNLGDSSPNIRGPVCVNTGLKCDYINSSCPVGGKKACIAFGPGEDMFESTRIIGENMFKIAKELYGSAKQELHGPVYGAHQWVNMTDETVQFNSTHTGRTCKPALGHSFAAGTTDGGGEFNFLQGDTEGDPFWDGIRDAVLGPPSNETKACHQPKPILFSTGEMDSPLPWHPAIVDVQIITIGSLAVVAVPGEFTTMSGRRIREAVKRELEVKEPFTNAEVVVAGLCNIYTHYITTYEEYQIQRYEGASTIFGPHTLSAYIQRYRGLAKAIAHGTIGELPKGPEPPFFDEDKLFNQVRDPVADVAPVGTTFGDVLQEVNPVYKVGEIASVTFVSGNPRHSGDIRDTTLVTVERFHNDTGSWEIIHNDASWETRFHWIKGLAGRSQAKVEWHIPQTAQAGTYQIQYFGHYKQTTENTTVITPYVGTSAAFKVARSFYYF
Protein: Toxofilin (Q9NG25)
Organism: Toxoplasma gondii
Interaction partners:
Sequence:
MAQYKSRPLAAFLLLITVGSLLTASESVQLSEGMKRLSMRGRSPSPKRGRFESGDEGTSTMSPSVAARQQELGLLRPEERLIAGQAKAAALQTVHQLGAVALTPEQAKAALLDEILRATQNLDLRKYENLNTEQQKAYEQVQRDLSQLSPETKALLIENQRKEKTLLEKARKLFQRRHYHVTKQAALAGQILNEQRDASGALQSGAVKTAIQRANEQYNVAEEDKNFNEEQHASQLKKVGAMPSS
Protein: 3-dehydroquinate synthase, chloroplastic (EC 4.2.3.4) (U3KRF2)
Organism: Actinidia chinensis var. chinensis (Chinese soft-hair kiwi)
Function: Catalyzes the second step in the shikimate pathway.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- shikimate dehydrogenase
- shikimate dehydrogenase
- Shikimate dehydrogenase
- Shikimate dehydrogenase
- 4-hydroxyphenylpyruvate dioxygenase
- chorismate synthase
- chorismate synthase
- histidinol-phosphate transaminase
- shikimate kinase
- anthranilate synthase
Sequence:
MAAFSLSAKQILSPSTHRPSLSKTTTADSSLRFRNPHSLSLRCSSLSSSSNVGRTRLMRASASSTAPVMDTSPTKAVSSAPTIVDVDLGDRSYPIYIGSGLLDQPDLLQRHVHGKRVLVVTNSTVAPIYLDKVVGALTNGNPNVSVESVILPDGEKYKNMDTLMKVFDKAIESRLDRRCTFVALGGGVIGDMCGYAAASFLRGVNFIQIPTTVMAQVDSSVGGKTGINHRLGKNLIGAFYQPQCVLIDTDTLNTLPDRELASGLAEVVKYGLIRDANFFEWQEKNMPALMARDPSALAYAIKRSCENKAEVVSLDEKESGLRATLNLGHTFGHAIETGFGYGQWLHGEAVAAGMVMAVDMSYRLGWIDESIVNRAHNILQQAKLPTAPPETMTVEMFKSVMAVDKKVADGLLRLILLKGPLGNCVFTGDYDRKALDETLHAFCKS
Protein: Tropomyosin 1 (H7BYY1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM
Protein: Dpr-interacting protein gamma (GH08175p) (Q9VAR6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Defective proboscis extension response 11, isoform B
- Enhancer of split m8 protein
- Defective proboscis extension response 16, isoform C
- Common Dpr-interacting protein
- Defective proboscis extension response 17, isoform A
Sequence:
MEKLLQSTLFVILIMATKCGSGSTQNQHHESSSQLDPDPEFIGFINNVTYPAGREAILACSVRNLGKNKVGWLRASDQTVLALQGRVVTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQINTSPMKKQVGCIDVQVPPDIINEESSADLAVQEGEDATLTCKATGNPQPRVTWRREDGEMILIRKPGSRELMKVESYNGSSLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQLLGTPLGSDVQLECQVEASPSPVSYWLKGARTSNGFASVSTASLESGSPGPEMLLDGPKYGITERRDGYRGVMLLVVRSFSPSDVGTYHCVSTNSLGRAEGTLRLYEIKLHPGASASNDDHLNYIGGLEEAARNAGRSNRTTWQPLLAMLMLLWMRLSLRTGGA