wanglab/gogpt-training-data huggingface dataset:
Protein: DmX-like protein 2 (Rabconnectin-3a) (U5U756)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MHLHQVLTGAVNPGDCCYSVGSVNDVPFTAYGSGCDIVILASDFECVQIIPGAQNGNIQVGCVECSQQLGRIAASYGNTVCIFEPISSNPNKRHKQLNYQWQKTGQFFLNAITYNLAWDPQGNRILAATERLQLWAPPASDALIEEEDSQLNDDRALELVLNDWKCVWQCKTAAAILITQWSPDGEYFATIGKDDCLLKVWYPTTGWKSAVVLPDVTDKKAPAVHFSFVYLAHPRTVTGFSWRKTSKYMPKGSVCNVLLTSCADGICRLWSETLLPEDSLLGGQISENSTSFSSSLPNVAQKDKIQHALESIHHLKHLRRGRRRSSALVAHTEVLPSQLGSHETHRHISHHANALCHFHISASINPNTDIPAALAGSGLFSEDASGGFVVHWLNNKDLSFTTSMDLFMQQLRKLSEQHLEQATEDFEQEGTAKFDFDLDEMSDKGSSEHEEGDQEGSTKASSPGSSSSVPLPSVLLDRKLETLILEWNKSPDMLFTIHPHDGSFLVWHVKYLDEFIPGIFRQVQVSFSSRIPVAFPTGDANSLSKNIMMYACTFMDQDSCSALEEKRSERRVPQSASASAGLSSLGHSLAAVIGPAVMMVSKHVDGSLNQWAVTFAEKSAFSNVLTVSHKFRYCGHRFHLNDLACHTVLPLLLTSSHHNALLTPPSGSGSIDGDLIGGVAQQPTRPMRGIPRKQLRNAATRTFHDPNAIYSELILWRVDHIGPLSCTGGVSELARINSLHTSAFSNVAWLPTLIPSSVLGTYCNSASACFVASDGKNLRLYQAVVDARKLLDELSDPETSKLVGEVFNIVSQQSTARPGCIIELDVITNQCGSNTQLLHVFQEDFILGYKPHEDIPDFNINSFPSGEDYQPPPFSEKFYLVVIEKDANRNSVLQMWHLHLRSVQACVEEPVNDYMFQNQLTVPLSQTNADSSPDITPGHSPLPRSSSSANLQSASKLILSSKLVYSQRLDLPPGVELIRATPSAGHLSSSSIYPVCLAPYLIVTTCSDGRVRFWHCRVDMDLSAPQPEETHSYRWEHWSLLKEEEDNDSSVCVAGRPVAVSCSYTGRLAISFKQISPASEGGLSQDFSMLVSIYECESTGGSEWVLEQTIHLDDFSKPAKTLDPRVSVDSNLFVYSKSDLFVTKDSPNIKHFVHLDWLSKEDGSHILTVGVGSNILMYGRISGIVTEQTGVKDGMAVTLPLGGSIKQGIRSRWVLLRSVNLVSSVDGTPSLPVSLSWVRDGILVVGMDCEMQVYAQWRQEEKLGDSEDNSISSPEGIGGRTVSVSHEGRARSKSVFEGSAGIDDALRPPAVIQDGGLFEAAHSLSPTLPQYHPTQLLELMDLGRVRRAKAILAHLVKCIAGEVAVVRDVEAGEGGARRHLSRTISVTGSTAKDTIVAGRDGGRDYTEINSIPPLPLYALLSADQETSYKAKWGRGDGEEVAKTGKGMDRDIQKQPEDHYADLFQVQSVTTDDFVSFATEKPEKKSRVINLSQYGPTYFGPEHAQVLSSHLMHSSLPGLTRLEQMFLVALADTVATTSAEVAGPTDKQYTGGDALDECGLRYLLAMRLHTCLLNSLPPLYRMQLLHQGVSTCHFAWAFHSEAEEEMLNMIPAMQRGDPQWSELRAVGVGWWIRNINTLRRMVEKVAKAAFQRNNDPLDAALFYLAMKKKAVLWGLFRSLHDEKMTQFFSHNFSEDRWRKAALKNAFSLLGKQRFEQSAAFFLLAGSLKDAIEVCLEKMEDIQLAMIVARLYEADYESSSTCQGILYEKVLGCNRDGSGFSCPKLHPDPFLRSIAYWIMKDYTRALDTLLEQIHKENDENPDVLVKSCNPVVFSFYNYLRTHPLIIRRHFANTEAPVAAVGPTTERNSADEINLIERKLFFTTANAHFKVGCPLLALEVLSKIPKVTKKASSLSKGSSVANISGVLPQENGGKASDLDWGTPAIPSQAWGADSSAGMDWSQPLVKVEDESLQLDWGDDKGEEEEDEEGGLTMRKPEDEEDKKPSKSAALQHEDSAGESEVDVIAEQLKFRACLKILMTELRTLATGYEVDGGKLRFQLYNWLEKEIEAMHHICNYKVEGKTTVGQLEKWGGDGSLDLEDSLIRGEAGAYERHQMERRRLQAKQLHAERRKAWLRKNQALLRVFLSYCSLHGAKGGGVTSVRMELLFLLQESQQEMTVKQLQSPLPLPTTLPLLSASIAPTKTVIANPVLHLRNHIHDILFTIVQMEAPPHPDILDDRVNALHTLAASLSACIYQSLCDSHSYSSQSEASQFTGMVYQGLLLSDRRRLRTESIEEHATPTSAPAQWPGVSSLISLLGCAQGDDYVRLNVMLCEAVVAVYLSLLIHGLGTHSGNELFRLAAHPLNNRMWAAVFGGGAKLIVKPKRPPEIAPAVPPPTPPAEDVDRQRRRFNMRMLVPGRPVKETPATPPPIPVERPTYKEKFIPPELSMWDYFVAKPFLPLSDSGALYDSDESGASDNEDDDDAFLSDTQMTEHSDPNSYSWSLIRLVMIKHGLHNVKTFLPLAGLDFTELPVTSPLCNAVLKTLENWEQLLLEKINKFDGPPPNYINTYPTDLSAGGGPAILRHKAMLEPENTPFKSKHHLSFPARRLWHFLVKQEVLQETMIRYIFTKKRKQSESIDDHVDHLIQNYVTGARKTSKVEADMGYPGGKAKVIHKESDIIMAFAINKANTNEIVLASTHDVQEVDVSTLVAAQPYTWIGEDFDKESRSSDDVDYRSSHTNIAQASTGPFAPQQMAASSSMPWLGTGQTSMGASVIMKRNLNNVKRMTSHPIYQYYMTGAQDGSVRMFEWNRPQQLICFRQAGNARVTRLYFNSQGNKCGVADGEGFLSLWQVNQTSSNPKPYLSWQCHSKSCGDFAFITSSSLIATAGQSNDGRNVCLWDTLIAPSNSMIHSFQCHENGATVLQYAPKQQLIITGGRKGFVCVFDIRQRQLLNTFQAHDSAIKALAMDSSEDFFVTGSAEGNMKVWKLAGHGLMHSFSTEHAKQSIFRNIGAGVMQIETCPGNRIFTCGADGTLKMRVLPDRYNIPASIFQILA
Protein: NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2) (O59923)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching.
Subcellular location: Nucleus {ECO:0000250, ECO:0000250|UniProtKB:P06700}.
Interaction partners:
- nicotinamidase
- Nicotinamide-nucleotide adenylyltransferase
- Glutamine-dependent NAD
- Trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase
- NADH/NAD
- Purine nucleoside phosphorylase
- NAD
- Nicotinamide-nucleotide adenylyltransferase
- Histone H4
- Histone deacetylase
Sequence:
MTTFWSQTINRQNGGVATATATATATAATTTPTAGGTGAGTTTSTKGMITPTPFNIDINNDLNDFDGKFIETFKPDLELQKKYRSFIQREGALSFLRTEITQSMSKRDICVLILNLGYPKKAVEDYPILTLKELAYILLKLMLTDSAQLEPKVEIDENDNKNDGTNNSDIDSDIDSNSDMDSQSESGELDDAMDVDDSLSENEDEYDQDMSTTTLKRTINMTPFKYKLPDLISDLSRAKKIMVVTGAGISTSLGIPDFRSFKGLYNQLSKLNLSDPQKVFDLQTFMREPGLFYTIAHLVLPPDGKFSLLHAFLKLLQDKHKLLRNYTQNIDNLEQRAGLKSEKLVQCHGSFAKAKCVSCQGIFAGEKIYNHIRRKQVPRCAICWKNTKQAPIHFGAIKPTITFFGEDLPERFHTLMDKDLQQIDLFLVIGTSLKVEPVASIIERVPYKVPKILINKDPIPNRGFNLQLLGLCDDVVSYLCKCLKWDIPHADFNNNDEFKLSKLKNGDWEIVKKSTSTKK
Protein: LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (A0A8I5ZZ77)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLPLSLLKTAQNHPMDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVREEAAKGRGRGGPQQQKQQKGRGMGGAGRGVFGGRGRGGIPGAGRGQPEKKPGRQAGKQ
Protein: Nuclear factor 1 (S4R3W2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
Sequence:
MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPREFKMAPSILGSPFWKVYSASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPILVPGIKVAASHHPPDRPPDPFSTL
Protein: Muscarinic acetylcholine receptor M3 (Mm3 mAChR) (Q9ERZ3)
Organism: Mus musculus (Mouse)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P20309}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P20309}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P20309}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. {ECO:0000250|UniProtKB:P20309}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Metabotropic glutamate receptor 5
- Guanine nucleotide-binding protein subunit alpha-11
- Muscarinic acetylcholine receptor M1
- Guanine nucleotide-binding protein G
- Kininogen-1
- Guanine nucleotide-binding protein G
- Muscarinic acetylcholine receptor M5
- Guanine nucleotide-binding protein subunit gamma
- HMW kininogen-II
Sequence:
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
Protein: CASP-like protein 1D2 (AtCASPL1D2) (Q9SQU2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:24920445}; Multi-pass membrane protein {ECO:0000269|PubMed:24920445}.
Interaction partners:
- CASP-like protein 5C3
- CASP-like protein 2A2
- UMP kinase
- Small polypeptide DEVIL 3
- Proteasome subunit beta type-7-B
Sequence:
MASTENPDPETGKSEPIPASATPPPSSAASFLDCRKIDIITRVLLFSATLTALIVMVTSDQTEMTQLPGVSSPAPVSAEFNDSPAFIYFVVALVVASFYALISTLVSISLLLKPEFTAQFSIYLASLDMVMLGILASATGTAGGVAYIALKGNEEVGWNKICNVYDKFCRYIATSLALSLFASLLLLVLSIWSALSKRT
Protein: NEDD8-activating enzyme E1 regulatory subunit (Ubiquitin-activating enzyme E1-like 1) (Ubiquitin-like activation protein 1) (Q9UT93)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Regulatory subunit of the dimeric uba3-ula1 E1 enzyme. E1 activates NEDD8/ubl1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc12 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- NEDD8-activating enzyme E1 catalytic subunit
- NEDD8-conjugating enzyme ubc12
- Ubiquitin-like protein 1
- Autophagy-related protein 8
- Ubiquitin-like protein ATG12
- Ubiquitin-like modifier-activating enzyme atg7
- Large ribosomal subunit protein uL1A
- Large ribosomal subunit protein uL1B
- Autophagy-related protein 3
Sequence:
MGTSAKMQKYDRQVRLWKAEGQNAIEKSHVCLLYANTVGCEALKNLILPGIGSFAVVDDTSVDFSMDGMNFFIQYDQEGKSRARCTASLLQQLNPNVEMEYLEMSPEALIDKNIEYFSKFSVVLSSNLKEKPLFRLEEYLRSHKIPLLHFNSVGFAGILRISTHEYTTTQSQPELPQDLRLKNPWPELINYVKSMDLDNMDSSSLSEIPYIVLIIHVLLKVSPAHAQNSQEADDCAMFRKIMEEYKGKCDSENIEEASSNSWKAFKEYKLPSNVYEVLHDTRCVKIQEDSESFWIMAHCLKMFYDETEFLPLSGLLPDMNCSTQQYVKLQVIYKEKSENDILKFKKYVQQTLKRLNRSVEEITDLEIKHFSRNCLNIKVMDFKTMKEEYQPTSNSVLESSSIDSNSLLPWYLAFRIYDTILEKHGKNYKEAFSDTTKTISVAQSFLSQIGLEKFFDVVYTAIQELERADGHELHSISSFIGGIVAQETIKLLAQQYLPLNNTFVFDGVHSRTETFKL
Protein: Transcriptional regulatory protein GAT1 (P43574)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Positive regulator of multiple nitrogen catabolic genes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Nitrogen regulatory protein GLN3
- Transcriptional regulator URE2
- Importin subunit alpha
- General amino-acid permease GAP1
- Glutamine synthetase
- Protein GZF3
- Forkhead transcription factor HCM1
- Protein GAT2
- Nitrogen regulatory protein DAL80
- Ammonium transporter MEP2
Sequence:
MHVFFPLLFRPSPVLFIACAYIYIDIYIHCTRCTVVNITMSTNRVPNLDPDLNLNKEIWDLYSSAQKILPDSNRILNLSWRLHNRTSFHRINRIMQHSNSIMDFSASPFASGVNAAGPGNNDLDDTDTDNQQFFLSDMNLNGSSVFENVFDDDDDDDDVETHSIVHSDLLNDMDSASQRASHNASGFPNFLDTSCSSSFDDHFIFTNNLPFLNNNSINNNHSHNSSHNNNSPSIANNTNANTNTNTSASTNTNSPLLRRNPSPSIVKPGSRRNSSVRKKKPALKKIKSSTSVQSSATPPSNTSSNPDIKCSNCTTSTTPLWRKDPKGLPLCNACGLFLKLHGVTRPLSLKTDIIKKRQRSSTKINNNITPPPSSSLNPGAAGKKKNYTASVAASKRKNSLNIVAPLKSQDIPIPKIASPSIPQYLRSNTRHHLSSSVPIEAETFSSFRPDMNMTMNMNLHNASTSSFNNEAFWKPLDSAIDHHSGDTNPNSNMNTTPNGNLSLDWLNLNL
Protein: Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H) [Cleaved into: Filensin C-terminal fragment; Filensin N-terminal fragment] (Q12934)
Organism: Homo sapiens (Human)
Function: Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulation of MIP water permeability.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q06002}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q06002}; Cytoplasmic side {ECO:0000250|UniProtKB:Q06002}. Cytoplasm {ECO:0000250|UniProtKB:Q02435}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q06002}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q06002}.
Interaction partners:
- Phakinin
- Lens fiber major intrinsic protein
- Beta-crystallin B1
- Gap junction alpha-8 protein
- Gap junction alpha-3 protein
- Gamma-crystallin S
- Beta-crystallin A3
- Beta-crystallin B3
- Alpha-crystallin A2
- Lens fiber membrane intrinsic protein
Sequence:
MYRRSYVFQTRKEQYEHADEASRAAEPERPADEGWAGATSLAALQGLGERVAAHVQRARALEQRHAGLRRQLDAFQRLGELAGPEDALARQVESNRQRVRDLEAERARLERQGTEAQRALDEFRSKYENECECQLLLKEMLERLNKEADEALLHNLRLQLEAQFLQDDISAAKDRHKKNLLEVQTYISILQQIIHTTPPASIVTSGMREEKLLTEREVAALRSQLEEGREVLSHLQAQRVELQAQTTTLEQAIKSAHECYDDEIQLYNEQIETLRKEIEETERVLEKSSYDCRQLAVAQQTLKNELDRYHRIIEIEGNRLTSAFIETPIPLFTQSHGVSLSTGSGGKDLTRALQDITAAKPRQKALPKNVPRRKEIITKDKTNGALEDAPLKGLEDTKLVQVVLKEESESKFESESKEVSPLTQEGAPEDVPDGGQISKGFGKLYRKVKEKVRSPKEPETPTELYTKERHVLVTGDANYVDPRFYVSSITAKGGVAVSVAEDSVLYDGQVEPSPESPKPPLENGQVGLQEKEDGQPIDQQPIDKEIEPDGAELEGPEEKREGEERDEESRRPCAMVTPGAEEPSIPEPPKPAADQDGAEVLGTRSRSLPEKGPPKALAYKTVEVVESIEKISTESIQTYEETAVIVETMIGKTKSDKKKSGEKSS
Protein: DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) (Q6PAL8)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:19141279, ECO:0000269|PubMed:22558185}.
Interaction partners:
- Ras-related protein Rab-6A
- DENN domain-containing protein 4C
- Sorting nexin-2
- Ras-related protein Rab-11A
- Sorting nexin-1
- Sorting nexin-8
- Vacuolar protein sorting-associated protein 26A
- Dynactin subunit 1
- Sorting nexin-6
- Vacuolar protein sorting-associated protein 29
Sequence:
MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADGGDQSGMEDGEGIPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGVPPEGNLHCSESASKLKRIRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGILLDSERRKSDASAVMSPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVECVMVRNEVTGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSLPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNDVVPEENWHTRARNFCRFVTAVNNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLDTSLVKGIDI
Protein: Methyl-CpG-binding domain-containing protein 5 (AtMBD5) (MBD05) (Methyl-CpG-binding protein MBD5) (Q9SNC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. In addition, binds specifically methylated m(5)CpNpN but not m(5)CpNpG (N is A, T or C). Plays probably a role in gene silencing.
Subcellular location: Nucleus {ECO:0000269|PubMed:14605234, ECO:0000269|PubMed:15010609, ECO:0000269|PubMed:15805479, ECO:0000269|PubMed:17208509, ECO:0000269|PubMed:18211904}. Chromosome {ECO:0000269|PubMed:15010609, ECO:0000269|PubMed:15805479, ECO:0000269|PubMed:17208509}. Note=Associated with heterochromatin, and particularly at perinucleolar chromocenters. {ECO:0000269|PubMed:15010609, ECO:0000269|PubMed:15805479, ECO:0000269|PubMed:17208509}.
Interaction partners:
- Methyl-CpG-binding domain-containing protein 7
- Methyl-CpG-binding domain-containing protein 2
- Methyl-CpG-binding domain-containing protein 1
- Methyl-CpG-binding domain-containing protein 8
- Putative methyl-CpG-binding domain protein 12
- Methyl-CpG-binding domain-containing protein 13
- Increased DNA methylation 3
- Methyl-CpG-binding domain-containing protein 3
- Methyl-CpG-binding domain-containing protein 11
- Methyl-CpG-binding domain-containing protein 4
Sequence:
MSNGTDQAQPPPENPATPVDSKSRKRATPGDDNWLPPDWRTEIRVRTSGTKAGTVDKFYYEPITGRKFRSKNEVLYYLEHGTPKKKSVKTAENGDSHSEHSEGRGSARRQTKSNKKVTEPPPKPLNFDFLNVPEKVTWTGINGSEEAWLPFIGDYKIQESVSQDWDRVFTLVTSQNAGKTMF
Protein: Beta-glucosidase 6 (Os3bglu6) (EC 3.2.1.21) (Q8L7J2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydrolyzes glycosides, oligosaccharides and hydrophobic glycosides. Possesses gibberellin ester beta-D-glucosidase activity. Can hydrolyze gibberellin A4 beta-D-glucosyl ester in vitro.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Endoglucanase 3
- Beta-glucosidase 16
- Beta-glucosidase 24
- Endoglucanase 14
- Endoglucanase 11
- Endoglucanase 15
- beta-fructofuranosidase
- Beta-glucosidase 25
- Os06g0656000 protein
- glucan endo-1,3-beta-D-glucosidase
Sequence:
MGRIKSSSGRCSTARLEAVAVLVVVFGVASSSLRGCIAQQSGGGLTRGSFPEGFVFGTASAAYQYEGAVKEDGRGQTIWDTFAHTFGKITDFSNADVAVDQYHRFEEDIQLMADMGMDAYRFSIAWSRIYPNGVGQVNQAGIDHYNKLIDALLAKGIQPYVTLYHWDLPQALEDKYKGWLDRQIVDDFAAYAETCFREFGDRVKHWITLNEPHTVAIQGYDAGLQAPGRCSVLLHLYCKAGNSGTEPYVVAHHFILAHAAAASIYRTKYKATQNGQLGIAFDVMWFEPMSNTTIDIEAAKRAQEFQLGWFADPFFFGDYPATMRARVGERLPRFTADEAAVVKGALDFVGINHYTTYYTRHNNTNIIGTLLNNTLADTGTVSLPFKNGKPIGDRANSIWLYIVPRGMRSLMNYVKERYNSPPVYITENGMDDSNNPFISIKDALKDSKRIKYHNDYLTNLAASIKEDGCDVRGYFAWSLLDNWEWAAGYSSRFGLYFVDYKDNLKRYPKNSVQWFKALLKT
Protein: Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B) (Q96QR8)
Organism: Homo sapiens (Human)
Function: Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:1448097}.
Interaction partners:
- Myosin-7B
- Transcription factor SOX-6
- Polymerase delta-interacting protein 3
- Transcriptional activator protein Pur-alpha
- Y-box-binding protein 1
- Small ribosomal subunit protein uS2
Sequence:
MADGDSGSERGGGGGPCGFQPASRGGGEQETQELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQTVNRGGGGFGAGPGPGGLQSGQTIALPAQGLIEFRDALAKLIDDYGGEDDELAGGPGGGAGGPGGGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNAITVPFKAWGKFGGAFCRYADEMKEIQERQRDKLYERRGGGSGGGEESEGEEVDED
Protein: Grancalcin (H7C2Z6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
XFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDCGGMNVINFEHLDTERPESVCKSD
Protein: Factor of DNA methylation 5 (Q9SAI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in association with FDM3 and FDM4 for RNA-directed DNA methylation (RdDM).
Interaction partners:
- Protein SUPPRESSOR OF GENE SILENCING 3
- Protein IDA-LIKE 2
Sequence:
MDNSSDEESEISESEIDVYYEKPYEKLMNGDYKVKVKDTFRCPFCAGKKKQHYKYKELLAHASGVAKGSASRSAKQKANHFALAKYMENELAGDADVPRPQIPSSSTEQSQAVVDDIYVWPWMGIVINPVRRTDNKNVLLDSAYWLKKLARFNPLEVKTLWLDQESVVAVIPQFNSGWSGFKSVTELEKEYEIRGCGRKDWIDKRGDWRSKAYGWCARADDYNSQGSIAEYLSKVGKLRSFSDITKEEIQNKSIVVDDLANKIAMTNEDLNKLQYMNNEKTLSLRRVLIEKDELDRVYKQETKKMQELSREKINRIFREKERLTNELEAKMNNLKIWSKQLDKKQALTELERQKLDEDKKKSDVMNSSLQLASLEQKKTDDRVLRLVDEHKRKKEETLNKILQLEKELDSKQKLQMEIQELKGKLKVMKHEDEDDEGIKKKMKKMKEELEEKCSELQDLEDTNSALMVKERKSNDEIVEARKFLITELRELVSDRNIIRVKRMGELEEKPFMTACRQRCTVEEEAQVQYAMLCSKWQEKVKDSAWQPFKHVGTGDRKKEVVDEEDEEIKKLREEWGEEVKNAVKTALEELNEFNPSGRYSVPELWNSKQGRKATLKEVIDYITQQVKTLKRRRA
Protein: Homologous-pairing protein 2 (Meiotic expression up-regulated protein 13) (Q9HGK2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis. Acts indirectly in a process facilitating homologous recombination. Acts during mid- to late-horse-tail period.
Subcellular location: Nucleus {ECO:0000269|PubMed:11447128}.
Interaction partners:
- Meiotic coiled-coil protein 7
- Meiotic recombination protein dmc1
- RNA polymerase I-specific transcription initiation factor rrn10
- Meiotic recombination protein rec12
- Meiosis-specific serine/threonine-protein kinase mek1
- Proliferating cell nuclear antigen
- DNA repair protein rhp51
- Protein byr4
- Folliculin-like protein bhd1
- Cell division control protein 16
Sequence:
MAKAKEVKAKPIKGEEAEKLVYEYLRKTNRPYSATDVSANLKNVVSKQVAQKALEQLRDTGLIHGKLYGKQSVFVCLQDDLAAATPEELAEMEKQIQELKDEVSVVKTLYKEKCIELQALNNSLSPAEIREKIQSIDKEIEETSSKLESLRNGTVKQISKEAMQKTDKNYDFAKKGFSNRKKMFYDLWHLITDSLENPKQLWEKLGFETEGPIDLN
Protein: Sushi repeat-containing protein SRPX2 (Q8R054)
Organism: Mus musculus (Mouse)
Function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations.
Subcellular location: Secreted {ECO:0000250|UniProtKB:O60687}. Cytoplasm {ECO:0000250}. Cell surface {ECO:0000250}. Synapse {ECO:0000250}.
Interaction partners:
- Urokinase plasminogen activator surface receptor
Sequence:
MMTSPLTQRGALSLLLLLMPAVTPTWYAGSGYSPDESYNEVYAEEVPAARARALDYRVPRWCYTLNIQDGEATCYSPRGGNYHSSLGTRCELSCDRGFRLIGRKSVQCLPSRRWSGTAYCRQIRCHTLPFITSGTYTCTNGMLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPILKPPQHGYLTCSSAGDNYGAICEYHCDGGYERQGTPSRVCQSSRQWSGTPPVCTPMKINVNVNSAAGLLDQFYEKQRLLIVSAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSAGIIEELRQFQRLTRSYFNMVLIDKQGIDRERYMEPVTPEEIFTFIDDYLLSNEELARRVEQRDLCE
Protein: Superoxide dismutase [Fe] (EC 1.15.1.1) (SodA superoxide dismutase) (O30563)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Interaction partners:
- Large ribosomal subunit protein bL17
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL3
- GlpE protein
- Endoribonuclease YbeY
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL2
Sequence:
MFKLPELGYDYDAVEPYIDAKTMEIHHSKHHNGFVMNLNSILEKMGKIHLTDVSNILKNIHDFPEEFQTLIRNNAGGYSNHTLYFRTLRPGNKDNLFEKFKDDINAAFGSLDVLKANLKDTAMKIFGSGWAWLVLCPESGLKVISMPNQDSPLMNSYKPILGIDVWEHAYYLKYQNRRIEYVDAFLKALNWEEVSKVYNEVIN