wanglab/gogpt-training-data huggingface dataset:
Protein: Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG) (Q9ESB3)
Organism: Mus musculus (Mouse)
Function: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis (By similarity). Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2.
Subcellular location: Secreted.
Interaction partners:
- Plasminogen
- Estradiol 17 beta-dehydrogenase 5
- Apolipoprotein A-V
- Carboxylesterase 1C
- Alanine--glyoxylate aminotransferase
- Fibrinogen alpha chain
- UDP-glucuronosyltransferase
- Coagulation factor XIII B chain
- Cytochrome P450 2C50
- Cytochrome P450 2A12
Sequence:
MKVLTTALLLVTLQCSHALSPTNCDASEPLAEKVLDLINKGRRSGYVFELLRVSDAHLDRAGTATVYYLALDVIESDCWVLSTKAQDDCLPSRWQSEIVIGQCKVIATRYSNESQDLSVNGYNCTTSSVSSALRNTKDSPVLLDFFEDSELYRKQARKALDKYKTDNGDFASFRVERAERVIRARGGERTNYYVEFSMRNCSTQHFPRSPLVFGFCRALLSYSIETSDLETPDSIDINCEVFNIEDHKDTSDMKPHWGHERPLCDKHLCKLSGSRDHHHTHKTDKLGCPPPPEGKDNSDRPRLQEGALPQLPPGYPPHSGANRTHRPSYNHSCNEHPCHGHRPHGHHPHSHHPPGHHSHGHHPHGHHPHSHHSHGHHPPGHHPHGHHPHGHHPHGHHPHGHHPHGHDFLDYGPCDPPSNSQELKGQYHRGYGPPHGHSRKRGPGKGLFPFHHQQIGYVYRLPPLNIGEVLTLPEANFPSFSLPNCNRSLQPEIQPFPQTASRSCPGKFESEFPQISKFFGYTPPK
Protein: Calcium-binding mitochondrial carrier protein SCaMC-2-B (Small calcium-binding mitochondrial carrier protein 2-B) (Solute carrier family 25 member 25-B) (A2CEQ0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Calcium-dependent mitochondrial solute carrier.
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 5
- NADH-ubiquinone oxidoreductase chain 2
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH:ubiquinone oxidoreductase core subunit S3
- Mitochondrial import inner membrane translocase subunit TIM22
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
Sequence:
MLCLCLYVPVHISERTEFEYFESESLPVQLKSLFKLSLFLPSQEFDSYRKWRKKVVKAGDKDLDGQLDFEEFVHYLRDHEKKLRLVFKSLDKKNDGHIDSQEIMQSLRDLGVHISEEQAEKILKSMDKNGTMTIDWNEWRDYHLLHPAENIPEIILYWKHSTIFDVGESMLVPDEFTAEEKNTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHATRSNSMGIAGGFTQMIREGGLRSLWRGNGINVLKIAPESAIKFMAYEQIKRLIGSNQETLGILERLVSGSLAGAIAQSSIYPMEVLKTRLALGRTGQYSGIADCAKHIFKKEGMTAFYKGYIPNMLGIIPYAGIDLAVYETLKNSWLQRFATDSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASQEGSPQMTMSGLFRHIVRTEGAIGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR
Protein: Carnitine O-palmitoyltransferase, putative (Q57YH1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
Sequence:
MTRVSTSKRRVAKESPLPLPSLREILECYVRFLEPLGNVENKEESLSFIRGVLLSLQASKGCAPDQLRDAVAYFRLLESIAKAYKQFCNESLHTSHMTPLWNAMYLSTRDPLPFGWNYTLQLDSPPLDNLAKGVGVSMQALRASIIGTASLHFRSLLGNPKFFTPEFQGRVPKMCRLDLSLCGDQFTRLFRTVRIPHEGVDGLRWSLTNKVLVLHRGNAFVVDWIRFGGINGNGSLERICVEEIIANAHLIEALKSKALSLPRNRSTPLVLANGCRKKWARAFGKLWLEQSSREALDEITSCSFGIALDENTDLSRCLHGGACPENRYPDMNVTYAIGPNGESSCNMEHSWGDGSTLAAVCAFVNYYNVSFSRCFTGAIDPPKTCLTVMEAHMHMVHWGNAICTHVLQDIQKFHRDHNLRVKQMTLALRRVNDFGTNEIKQRCGSSPDAFMHAAFHIAQKRLFGDQRSTYCALLMKKYHHGRTETLRTVTHSTQTLAKLVESAKGERSFSPNIRTALHNVSEEHRERIILCRSGKGFHRAVTLLSRFHKEVQERLHHNPSTDVPWDVNKGVTHVEKMFFASQALRELCSDYLSTSNMSAPGILSFSFAATHPDGVGIGYSLSPKQLSFTVSAFTECKRPLAGDQACEETNVAIAFANAIEDAVKDLYDRTALPLQSKL
Protein: Uncharacterized rhomboid protein C19B12.06c (EC 3.4.21.-) (Q9P375)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MAIELGERISTSVGFLAELFLMKIPLFTVIVALLTIILGIVNIFLPIVDFFGLSWHNLINIRLHTLNTYPLVHHGVISFILGLLGIFLLMPRFERRYGTLCTIAMFFGFLEVIPAIAYLIACYVAESDDVYVGIGGWVYSLLAMYLLNLFGDLHPKLLNLPQVVRMALALVAPVLGLPLDFSITIVLHLTAVVISIIFSFAYMDFFLPRGGFLVWVETKFSKIIDAIPNYISVTEAAYYQADGAIPIQDLGSNSSGIV
Protein: Protein ripply2.2 (Protein bowline) (Q25QX6)
Organism: Xenopus laevis (African clawed frog)
Function: Required during somitogenesis for the formation of somite boundaries. Represses the expression of genes involved in somite segmentation by acting with the corepressor tle4 to down-regulate the transcriptional activity of tbx6. May act by regulating the activity of tle4. Represses transcription of delta2, thy1 and ripply2.2/bowline itself.
Subcellular location: Nucleus {ECO:0000269|PubMed:16586348}.
Interaction partners:
Sequence:
MDNINTTIDICGAASGLPSPGDSNSKRLRHRKYLPQRWKCEPRGPARTETQRPQTLFWRPWLLKSHKPKTQAHPYARGLRENPQEQKPVEYNHPVRLFWPKSKLLDNTYQEAADLLRNFPVQATISLYNDSESDTDNEEDSSEEEQDSGFESE
Protein: Squamosa promoter-binding-like protein 16 (SPL1-related protein 3) (Q700C2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGELPKDDWQMNRWKWDGQRFEAIELQGESLQLSNKKGLDLNLPCGFNDVEGTPVDLTRPSKKVRSGSPGSGGGGGGNYPKCQVDNCKEDLSIAKDYHRRHKVCEVHSKATKALVGKQMQRFCQQCSRFHLLSEFDEGKRSCRRRLDGHNRRRRKTQPDAITSQVVALENRDNTSNNTNMDVMALLTALVCAQGRNEATTNGSPGVPQREQLLQILNKIKALPLPMNLTSKLNNIGILARKNPEQPSPMNPQNSMNGASSPSTMDLLAALSASLGSSAPEAIAFLSQGGFGNKESNDRTKLTSSDHSATTSLEKKTLEFPSFGGGERTSSTNHSPSQYSDSRGQDTRSSLSLQLFTSSPEEESRPKVASSTKYYSSASSNPVEDRSPSSSPVMQELFPLHTSPETRRYNNYKDTSTSPRTSCLPLELFGASNRGATANPNYNVLRHQSGYASSGSDYSPPSLNSNAQERTGKISFKLFEKDPSQLPNTLRTEIFRWLSSFPSDMESFIRPGCVILSVYVAMSASAWEQLEENLLQRVRSLVQDSEFWSNSRFLVNAGRQLASHKHGRIRLSKSWRTLNLPELITVSPLAVVAGEETALIVRGRNLTNDGMRLRCAHMGNYASMEVTGREHRLTKVDELNVSSFQVQSASSVSLGRCFIELENGLRGDNFPLIIANATICKELNRLEEEFHPKDVIEEQIQNLDRPRSREEVLCFLNELGWLFQRKWTSDIHGEPDFSLPRFKFLLVCSVERDYCSLIRTVLDMMVERNLGKDGLLNKESLDMLADIQLLNRAIKRRNTKMAETLIHYSVNPSTRNFIFLPSIAGPGDITPLHLAASTSSSDDMIDALTNDPQEIGLSCWNTLVDATGQTPFSYAAMRDNHSYNTLVARKLADKRNGQISLNIENGIDQIGLSKRLSSELKRSCNTCASVALKYQRKVSGSRRLFPTPIIHSMLAVATVCVCVCVFMHAFPMVRQGSHFSWGGLDYGSI
Protein: Poly (ADP-ribose) polymerase family, member 9, isoform CRA_b (Poly(ADP-ribose) polymerase family member 9) (G5E9U8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDFSMVAGAAAYNEKSDLEIYKAFSSEMAKRSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNVEEMYEAHAWIQRILSLQNHHIIENNHILYLGRKEHDILSQLQKTSSVSITEIISPGRTELEIEGARADLIEVVMNIEDMLCKVQEEMARKKERGLWRSLGQWTIQQQKTQDEMKENIIFLKCPVPPTQELLDQKKQFEKCGLQVLKVEKIDNEVLMAAFQRKKKMMEEKLHRQPVSHRLFQQVPYQFCNVVCRVGFQRMYSTPCDPKYGAGIYFTKNLKNLAEKAKKISAADKLIYVFEAEVLTGFFCQGHPLNIVPPPLSPGAIDGHDSVVDNVSSPETFVIFSGMQAIPQYLWTCTQEYVQSQDYSSGPMRPFAQHPWRGFASGSPVD
Protein: JmjC domain-containing protein 1 (Jumonji domain-containing protein 1) (O13977)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- JmjC domain-containing protein 4
- Jumonji/ARID domain-containing protein 2
- Multicopy suppressor of chk1 protein 1
- Lid2 complex component jmj3
- Putative JmjC domain-containing histone demethylation protein 1
Sequence:
MVYRPTAHEFDDLPKIEFIDSCPYQVFLEQYLKPCVPVLIGPKLTAQWKANTTWITSKGDPNILHSYILPDKPCTSRDNTSGNSLLNDNDIKNFIRSYAERIVNNEDKNVFLDSLLLSPNYEYLEENYGTIPVPLAYCNEKDRYGSQRRETVPLKSALHELRDEQVQLQCRQAPSNQALKSLYAKDMHLFRHLDPADFPYSTPDIFADDWLNAYVIDCESDDFRFAYLGSHLTTTGLHTDVYASHSFSVNLCGVKCWLFIDPKDLQTIASLYDDQQLPSWITKDDLFRGPLVNHRHLIKILFQYPGQTVFVPSGWYHQVLNIGTTLSINHNWCNASCILQMYTALKEQYEVSAESLKDLLEDGIVTKDRFSQVVTEVVEANYGWCWRRFWGMIKHQLKRRDAILHSSEYFSKWPIQPEFLPPLSWEYSILKNILLNDEPGSTFDSGSPPSSIVTIFKSLGDFKE
Protein: Zinc finger protein GLI1 (A0A5K4F1D0)
Organism: Schistosoma mansoni (Blood fluke)
Function: Probable transcription factor which plays an essential role in males to trigger female sexual development by inducing NRPS expression in male. NRPS produces the pheromone beta-alanyl-tryptamine (BATT), which stimulates female sexual development.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P08151}.
Interaction partners:
- Suppressor of fused, putative
- MATH domain-containing protein
- non-specific serine/threonine protein kinase
- Frizzled domain-containing protein
Sequence:
MTGSDSSMCDLEVKSSLSLTSHLHEYQRNPLFHINTTTLTTTTTINNHINTTSTNNYQQQNDTMYDNNNNNVDNDMKVKSSMNDCINDNTINDTHSTTVIHAENENPRRPIPLTNTSNLEGSTSNVGGNSNFQTMSGNTIPFLPISATNDGRYEWPPSMRYSSANTDRFIQGINTNTDNRQEDFRNQLTSNNNNNYNFKSNNTADNEINQTNHHNLPQFANEKLLDSVRSKNFNNTNISNKVECSSPDANMVAAVAFNAVRRWFTNSSTLTNSDNTMKSVWNENMRTGNSGTNSIGFMNQSNILPYASLNSRLQHPLLPPPLVLNSTVGNATTQNSTHNNYGMFMHRGHHSSGYVPNHTAPMLRGGKKRSHSQSSVNELFDISSLTRSSQGSLNIMQSMRGSHSMGPSAEGSYGHLSAASLGASPGASCDIRRTLSSNGNSSHTAPPAPFSERSPFWSPNSPHSSGSGFDNYQTSSHKSLPLPSTLQTYQQHSGYTSTSGSSGNRSTGCLNRAPFGHLAVLSSSNSLNKQIQQQSDSNSVSNCSIDVPKKLTTNSSNMILPSCRTLGLPTNSVTVSSSEITKNCNNNVLQSAMAFAAVAVAAAAASSTTSSITERENSSLLNKHVLENTLHRECRDHGLHQHPSSECESCSSTLTMGNNNNKLNESINSVYNNLVPSCFMKPPSSATIKSLATTTDNNNSNTNILSNDLSTDNRNKSLNKLPCYNNDADANDTCMDATNNENIQQGVLRKIIPSTPSHFQFSSKTYNQLTQNNSSNKPITAVNNGNDVNNGGNMSSSFTNPLHWPFESIPTPDWSHTWFNNNNNNNTNSTIRFQLNPNETIRRNGRVKIEQIDLNSTVLSKSEMSELLINENSNNNHHHLFGKGNNLLCPTLTKDLLKQHCALNNSDINSITNSLLNQQSSQRKQIDGTLNQMRGIKNFGRTCRITPVLEAITPGITTSISETSAVASSSTTAATPTTTGLFKQKSIEHSHKWQNQNVFSSRRNSTRDPSNNNNSGVGRCSVDEPDVDDDEELDDDGRVPQEGDPDFVETTCRWGDCTLQFDDQDELVKHLSTEHIAGNKKSFVCLWRECVRGTRPFKAQYMLVVHMRRHTGEKPHKCIFEGCIKRYSRLENLKTHLRSHTGEKPYQCEIPGCNKAFSNASDRAKHQNRTHSNEKPYTCKVDGCSKRYTDPSSLRKHVKTVHGAESLMKTSLQKKNSFGVNMLMKVYANKKHKGESWSDRPCGGSGFGGGHLFGNSNNNNSYPSQDKRSNGSMPGIRGRFGPRGMNDNGNIFHRGTYTDREQRPSSSSNPRDSCLACLSNPVHTTTIHPVDINAESIITEYPNQDLSKLKRFSIEESGRNTSHNMNWYLPETDNQNVHSSVLMMASSPAVYNTRNDYFPSFKCEHSIYPNYFSFARNMIHTEDTNQNDNNNNNLVLSWTSPTTPSPCDNLYLDQKINPSITLQPLSTTSNPVQSLSPSIDNPINSTGTKQKNLFSPVNESVTMIRNENCDQSKPVCVYGTSDDLAKDFKKSLKTEENNLIWNWKYSQPSIDGMNKDHCNKKHSILRFDDQDMKKPLPGYLSTSLESRSNTQLALNPNDQTVNQLTRSINNEHFNEMSNMSTTTINETYRENNLQFNFPLKWKVEDPLAYSKNMDNNSQTKNNNELNEENSPQSNQNECISNVPLLNNHYLEDVTEQKSQLCVIECPNRLRSMQDICSSNDIWDSESAAASSGIGSGVTTTTASDNSNPTAQNHHHQKQQPKHSHQHQNRTKSINSDNNYSNQDNVSTMDNDETFFNNENIKSDLGSIDRSSLFGTPRTDSNSTGCSYERTFNPQINYKNDNLIHSSCTCIQKRQKRDNSQSTCSYHRHYHDQLVDGNISSQLDSEQLSATSSQVSSGLGSMTSSNAGSGCNCTGTGLNNTNINVLDNVSGNVSSNICVNTLPRLVEGDNSSNLTNDYPNNSQVFNEDDNNISKMWRKYYKSYGYCSPCNNQPETFYPEVFNSETECYSNTPATVINGLSSTASPVPPSISTYHYHHNPHLHHQHQQRQSQHNLDLVMSNSNHYNDEMHFSPHSYVHSSSSNSSPFNSNRPHSVETFSHNNLTNNSLFDHRRYTHTSLSTTNNNHVNEMNNSINQINPKHPYNICLSSINNNNNQCDTNSNMILKRHSITDDLCHVNGTWFTNEYNGNDNHHYWTHPYNVNQLSIGNQIPNWLNKSVLTSSSPSSSSRLTSTSLTEAIRTHNSSDSLCVTSRFNDSINYYQEYTNCCQPTINSFQINQSSLSSTMSTKTSAKLQSKLSWTTDDNYSEYLCSNHSQNSYIQSNRLVNNNNSSNNDNLIEMDRNNRTNIQRNCSSELNCYTNFQNNTTQLENMDHINTNPLLISLASSQPFLMSSFNTTSISTTSEQTPYSSYHLTPTSNTVHQISQRGIEQMNKMNNLHSNNQLSTIASVTASETTTSTSTVSSYQNLKEREVYNFPVPNPLHTYINPFHSSNSLYSSFLQSVFEEPTFTSSSSSSSPSPSLLLSSSSSTHLGHFNQLFVNADPISNNLVVCNMSTMDTDCAPFHSSN
Protein: Claudin 34C5 (A0A571BDD5)
Organism: Mus musculus (Mouse)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MVLLNKSANHQIRGFTLATIARIMCNTSMALPEWRNCYLNNSMLSYPSLAFVNIWEAYICHHNHNSSHLRDCHYYTCHNNLVPLDIRVSQILLLVANVVGLVGTVCSVFALQQLNTEELHKNNDYNPFVLSAVLNAIASTFIFLAVMCNHLSVPSKEEVSFLQSFQMPIFSNAQRAGRAMGLAYISAILFLLSAIIFISYCPSMEIKMFPRV
Protein: LD29301p (Q960Y9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEDIEYLDEYKDLVLPGIKSSAPTASSAGVPRQRRISSDSSNSSSIDADIFQKLFHGKYLDDELLKEGSGSKSQDRRRRPPSPSSSDESNDALEALFCGKSSQSKLSKRRERYESFDSVDDLGEALMRPSHRLTVPKPSTSQAGSKKSQDAAPHRSISNSSSSNIAMSSGQTYACPKNKKTNSVANKTAVSANGDKWASGKNKTVTIVKPQKTDLRPSRLEPKTDPLNLGDLYGDSDSDSSYEYESDFYGDQDSDEEDEPVIDISTDTSRTTSVADTVTPVVSDDEGQEPQSELNQRHANDQESFLSSTYERLQSYLSNLSSAEPPPIYKKQNSARKSRSNEKKPSSSQQVKHANEQSAASDKEANKKERDLEPPEASSSAKSSASKASGSRKLYDVANNATLEAVERMSLDLAEQIMEIDVERSYEFEKRSASKSRSLSRSKIPADSSTSQLGHVRKLTYSSERLDQPEPLGTQLRRSKSESLPKRGRPRGQKQRKNRGATMEEKSANCRDGEGEPVKRKRGRPRKIIPKEEAKTAETENTIESLNTNVPLSIDTSKENPETETVNLEVPIKQDELVSDLDNAKELTGSTNLPQDDIEMASNHQETDLKCAPDRVALDKSESTPKVEEEQLCKVDTPSDTALDESKVSESAKNHIELEDKDKDKEETQKESPNGNSKETNENSVIVTNEVELPAKKAEAKAEAGNIVEESDSQLAEDFKLAEEILAAEVGKGVEANEVSVTSVQGEQNPVIEIVKELEQETISEVVPAQNDQSSVEDQTLADKENPVEKPSPVKAPSSSKDEPPAEENLPAPDQDPIEQQKTPVAKNQQHDKEHNEAPKAESLSVSDIPSSSVTPSKKRNHSSPANTPKKSKEIEALQSSVPRRALRSDKATPQNLRESRSKRTLKTELTLLMDDTMRRSSPRLGRSPAESHSSHERSPMEKKVTVSKLAKDLITIDKEKEIELKSLPDASETKDVKITKTTTASDTSILTDENPSSSKTEMKKLKGKPLKAKKMSRTSETEVKKAIADSNEDIPSIFSIKCVEEHLTSSESEQKDEKEELLCPKPQIDCTNTDLEQSTAIETDTEQVEEKRSNRRKSRRIRNEKFKTETDTFRPFGCKESGECISGN
Protein: Aldehyde oxidase 1 (EC 1.2.3.1) (Azaheterocycle hydroxylase 1) (EC 1.17.3.-) (Retinal oxidase) (O54754)
Organism: Mus musculus (Mouse)
Function: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imidacloprid (IMI) via its nitroreduction to nitrosoguanidine (IMI-NNO) and aminoguanidine (IMI-NNH(2)). Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Cannot use xanthine and hypoxanthine as substrate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10377246}.
Interaction partners:
- Nicotinamide N-methyltransferase
- Dehydrogenase/reductase SDR family member 4
- Aldehyde dehydrogenase, mitochondrial
- Aldehyde dehydrogenase 1A1
- Retinaldehyde dehydrogenase 3
- Amine oxidase [flavin-containing] B
- Amine oxidase [flavin-containing] A
- All-trans-retinol dehydrogenase [NAD
- Aldehyde dehydrogenase, cytosolic 1
- Pyridoxine-5'-phosphate oxidase
Sequence:
MDPIQLLFYVNGQKVVEKNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKAIRHHPVNACLTPICSLHGTAVTTVEGLGNTRTRLHPIQERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFCKASACCQSKENGVCCLDQEINGLAESQEEDKTSPELFSEEEFLPLDPTQELIFPPELMRIAEKQPPKTRVFYGERVTWISPVTLKELVEAKFKYPQAPIVMGYTSVGPEVKFKGVFHPIIISPDRIEELGVISQARDGLTLGAGLSLDQVKDILADIVQKLPEEKTQTYRALLKHLRTLAGSQIRNMASLGGHIVSRHLDSDLNPLLAVGNCTLNLLSKDGERRIPLSEEFLRKCPEADLKPQEVLVSVNIPWSRKWEFVSAFRQAQRQQNALAIVNSGMRVLFREGGGVIEELSILYGGVGSTIISAKNSCQRLIGRPWNEGMLDTRCRLVLDEVTLAASAPGGKVEFKRTLIISFLFKFYLEVSQGLKREDPGHSPSLAGNHESALDDLHSKHPWRTLTHQNVDPAQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDIITADHLQEANTFGTETFLATDEVHCVGHLVCAVIADSETRAKQAAKQVKVVYQDLAPLILTIEEAIQHKSFFKSERKLECGNVDEAFKIVDQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKYIQDIVAATLKLSANKVMCHVRRVGGAFGGKVGKTSILAAITAFAASKHGRAVRCILERGEDMLITGGRHPYLGKYKAGFMNEGRILALDVEHYCNGGCSLDESLWVIEMGLLKLDNAYKFPNLRCRGWACRTNLPSNTALRGFGFPQAGLVTEACITEVAIKCGLSPEQVRTINMYKHVDTTHYKQEFSAKALSECWRECMAKCSYFERKAAIGKFNAENSWKKRGMAVIPLKFPVGIGSVAMGQAAALVHIYLDGSALVSHGGIEMGQGVHTKMIQVVSRELRMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQGTWKDWAQTAFDQSISLSAVGYFRGYESNIDWEKGEGHPFEYFVFGAACSEVEINCLTGDHKNIRTNIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSYSPQGTLYSRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVKAARQERGISGPWKLNSPLTPEKIRMACEDKFTKMIPRDEPGSYVPCNIPV
Protein: AT27686p (Q8MRR9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGNQDTLGQSQQVNESGDEYEEDAATSWTNELEQQESRTPADSPEFLDFVDSEDPLEDFERNPLQKEPLDLAVKPVSDINKKAAENHRRIYRQLGIHIPETPKSHPLLHYAFVVKLFLATDNSSIHFLKWSANDRELEVDYQGMQEHLSSGCSMFHCRNTLQFTGTLLAHGFERVSLKDVRKSSVTNITLIYRNPNFVKGQLLKLHKLAQECEKIPEISSPETAEPRRPPLHLPNHAHISRMVRRGDLCSTPYTSRSALQVARCHFQTLLGYQADLGVLKDRNNHDMFNKNIMTQLNVKRGRSSINNAPVDLAPSKVSFEKFVKPHESVINIGIGQAPDYAGYYGQVELFKVNEFFSEYLPRYGSKITGYKEIVMDATNKSIGFQQNLPIGMNYSDDEDDALPPISSDLDLDFMPSTSAAAKMKSTGRKVVEDSDLEQAMQELCGGSNLNEEEELPQTSTRFKAKPKPRAKTKAKPTKRQAKPVHSSSSECEDFKPDEVYEGFKSRNPKNVKLKPSDENISYTLEEGTDFEEQVIEETTETKVQDSQYDDLDDDDDDEEEDYFDEDDEDYVYKNLQYRNPPEPPKSRRYDLRNSKRNPR
Protein: EF-hand domain-containing protein (Q388Y0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 1-phosphatidylinositol 4-kinase
Sequence:
MGYTFSRAQMEDYKELVKGRFSDGAIEFLFLKFHRAAPNGIMTPVDFKHYIESTEVFKTYKHTHSKSYLKNVDEDSEEEDGGGGGERIGSSSSEMYEHLFRGYDRDCDGVISFSEFLLYHLAVIYSTEELFVVVFNAYDADQDGFLSLNDIVTTITAATKYVGDCDIDDPEVKRVINEEAQRLMMFLDVRKDGRIRPEDMRLITQKHPEVLEKMKNLM
Protein: DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) (Q2KHR2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
Interaction partners:
- DNA-binding protein RFXANK
- Ankyrin repeat family A protein 2
- DNA-binding protein RFX5
Sequence:
MAEEQQQPPPQQPDAHQQLPPSAPNSGVALPALVPGLPGTEASALQHKIKNSICKTVQSKVDCILQEVEKFTDLEKLYLYLQLPSGLSNGEKSDQNAMSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGAEPSGQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELARFLVKSHYIGTKSMAALTVMAAAPAGMKGITQPSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGESAAKKSESATSNGVTNLPNGNPSILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMSSSDGKVLPLNVQVVTQHMQSVKQAPKTPQNVPASPGGDRSARHRYPQILPKPANTSALTIRSPTTVLFTSSPIKTAVVPASHMSSLNVVKMTTISLTPSNSNTPLKHSASVSSATGTTEESRSVPQIKNGSVVSLQSPGSRSSSAGGTSAVEVKVEPETSSDEHPVQCQENSDEAKAPQTPSALLGQKSNTDGALQKPSNEGVIEIKATKVCDQRTKCKSRCNEMLPGTSTGNNQSTITLSVASQNLTFTSSSSPPNGDSINKDPKLCTKSPRKRLSSTLQETQVPPVKKPIVEQLSAATIEGQKQGSVKKDQKVPHSGKTEGSTAGAQIPSKVSVNVSSHIGANQPLNSSALVISDSALEQQTTPSSSPDIKVKLEGSVFLLDSDSKSVGSFNPNGWQQITKDSEFISASCEQQQDISVMTIPEHSDINDLEKSVWELEGMPQDTYSQQLHSQIQESSLNQIQAHSSDQLPLQSELKEFEPSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMTLQSQSVTPGAPMSSHTSSTHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYSGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDTHFGRLTPVSPVQHQGATVNNTNKQEGFAVPAPLDNKGTNSSASSNFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQANSKKITNVLLSKLDSDNDDAVRGLGMNNLPSNYTARMNLTQILEPSTVFPSANPQNMIDSSTSVYEFQTPSYLTKSNSTGQINFSPGDNQAQSEIGEQQLDFNSTVKDLLSGDSLQTNQQLVGQGASDLTNTASDFSSDIRLSSELSGSINDLNTLDPNLLFDPGRQQGQDDEATLEELKNDPLFQQICSESMNSMTSSGFEWIESKDHPTVEMLG
Protein: Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) (P28271)
Organism: Mus musculus (Mouse)
Function: Bifunctional iron sensor that switches between 2 activities depending on iron availability (By similarity). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P21399}.
Interaction partners:
- Citrate synthase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- Citrate synthase
- Isocitrate dehydrogenase, mitochondrial
- ATP-citrate synthase
- Isocitrate dehydrogenase subunit alpha, mitochondrial
- Isocitrate dehydrogenase subunit
- Isocitrate dehydrogenase subunit gamma 1, mitochondrial
- Probable isocitrate dehydrogenase gamma 2, mitochondrial
- Aconitate hydratase, mitochondrial
Sequence:
MKNPFAHLAEPLDAAQPGKRFFNLNKLEDSRYGRLPFSIRVLLEAAVRNCDEFLVKKNDIENILNWNVMQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNKERFEFLKWGSQAFCNMRIIPPGSGIIHQVNLEYLARVVFDQDGCYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYKLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSIAYLLQTGREEDKVKHIQKYLQAVGMFRDFNDTSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSEMKKDFESCLGAKQGFKGFQVAPDRHNDRKTFLYSNSEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVEAGLSVKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTVRIDFEKEPLGVNAQGRQVFLKDIWPTRDEIQAVERQHVIPGMFKEVYQKIETVNKSWNALAAPSEKLYAWNPKSTYIKSPPFFESLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTVHLPSGETLDVFDAAERYQQAGLPLIVLAGKEYGSGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGETADSLGLTGRERYTINIPEDLKPRMTVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKMAQ
Protein: RNA-binding protein, putative (Q388P4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNFSPLANPQCVFSSPSIGNVNDDTGMGYSPKHCDNDVGRADSHGAVTHRQSRTFSTGHMTNMVHHAQQYPVSRGNRHTRVGSKLFVGQVPAVATEKQLRPVFEPYGELLEVKIMRDSMGRSKGSAWVRYRTDEMASSAIYALHEKHTVPPQTNPLRVQFATISKARCPNQQVYTMSSRAPMAQIPGETGMVGMPLRLGASVNMFPPTIADNNGGYTLPSSIHSQSVPGTGSGPYTSSTNRVDGLDRNRGSYSSFSVEEQPYTSAPRLYQFESVVYPSATAPHSNVYNQHVHTQQKQSESGSNKKETCTGRTWTFDVADDEHIESLQNDASISRNGGLSLNNGNISWDDEKWQSPTGAMIRLSGSGE
Protein: Ras protein let-60 (Abnormal cell lineage protein 34) (Lethal protein 60) (P22981)
Organism: Caenorhabditis elegans
Function: The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1. May induce nuclear condensation.
Subcellular location: Cell membrane; Lipid-anchor.
Interaction partners:
- Raf homolog serine/threonine-protein kinase
- Ral guanine nucleotide dissociation stimulator-like 1
- Son of sevenless homolog
- Sex muscle abnormal protein 5
- Receptor tyrosine-protein kinase let-23
- Phosphatidylinositol 3-kinase age-1
- Dual specificity mitogen-activated protein kinase kinase mek-2
- Mitogen-activated protein kinase mpk-1
- Rap guanine nucleotide exchange factor
- Leucine-rich repeat protein soc-2
Sequence:
MTEYKLVVVGDGGVGKSALTIQLIQNHFVEEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNEAKSFENVANYREQIRRVKDSDDVPMVLVGNKCDLSSRSVDFRTVSETAKGYGIPNVDTSAKTRMGVDEAFYTLVREIRKHRERHDNNKPQKKKKCQIM
Protein: Cardiotrophin-1 (CT-1) (Q16619)
Organism: Homo sapiens (Human)
Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
Subcellular location: Secreted.
Interaction partners:
- Leukemia inhibitory factor receptor
- Interleukin-6 receptor subunit beta
- Ciliary neurotrophic factor receptor subunit alpha
- Oncostatin-M-specific receptor subunit beta
- Oncostatin-M
- Leukemia inhibitory factor
- Pirin
- Interleukin-11 receptor subunit alpha
- Interleukin-6 receptor subunit alpha
- Ciliary neurotrophic factor
Sequence:
MSRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPSFSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLRRLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGLYREWLSRTEGDLGQLLPGGSA