wanglab/gogpt-training-data huggingface dataset:
Protein: Vesicular acetylcholine transporter (VAChT) (rVAT) (Solute carrier family 18 member 3) (Q62666)
Organism: Rattus norvegicus (Rat)
Function: Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis. Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern. Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation (By similarity). Can transport serotonin.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:9182805}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Vesicular inhibitory amino acid transporter
- Vesicular glutamate transporter 1
- Vesicular glutamate transporter 3
- Vesicular glutamate transporter 2
- Choline O-acetyltransferase
- Synaptic vesicular amine transporter
- Sodium channel protein type 10 subunit alpha
- Chromaffin granule amine transporter
- Leucine-rich repeat neuronal protein 3
- AP-2 complex subunit sigma
Sequence:
MEPTAPTGQARAAATKLSEAVGAALQEPQRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGSEGPTLVSEVWEPTLPPPTLANASAYLANTSASPTAAGSARSILRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLREVQGKDGGEPCSPPGPFDGCEDDYNYYSRS
Protein: Inactive dihydropteroate synthase 2 (DHPS 2) (Dihydropteroate pyrophosphorylase 2) (P9WNC9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Has very low affinity for the DHPS substrate 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism.
Interaction partners:
- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
- Dihydrofolate synthase/folylpolyglutamate synthase
- Dihydroneopterin aldolase
- Dihydropteroate synthase
- GTP cyclohydrolase 1
- Bifunctional aminodeoxychorismate lyase / D-amino acid transaminase
- Glucosyl-3-phosphoglycerate synthase
- Thymidylate synthase ThyA
- Phosphoribosylglycinamide formyltransferase
- Probable DNA-3-methyladenine glycosylase I TagA
Sequence:
MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALIMAIVNRTPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTEITRLVPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDPAMPEVAAEFGAGLVCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAAAERAVAAGVAREKVLIDPAHDFGKNTFHGLLLLRHVADLVMTGWPVLMALSNKDVVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEMVASIQGVRPPTRTVRGLA
Protein: TNF-receptor-associated factor 2 (Q9XYQ9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MHQHAHTHSHAHSLQHAEEKEHNSNEMTTNLSSTGRIAASSSATPSAAAGGGASGAPTPPKSLALNQNHHYAPGSDTSGEQEEELLDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCWPMDNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPSCPYRRQQEPQEEKCPFAKIKCDFVGRPETNQLEEHLKADMPHHMQLMLQAFQQTAIATWQPHKPSTSGAAVENGHGQQQLPPPPPYANGVDEQIVQTMYQRIVVLEQRTREQETRLENMQKQLRLARQQAPVDPRYSNGTIVWRIEQLGALVARLRANANNQVYSHECYTSPHGYKFCARLTFSRGKPHVLSLHVHLMQSENDYHLDWPFKGRIKLCMVHPADATLSQHDTIMTKPEILAFHKPREAISTRGFGFLEYANISNIIQLGFCADDRLLIKIEINIV
Protein: Sodium/hydrogen exchanger 9B1 (Na(+)/H(+) exchanger-like domain-containing protein 1) (NHE domain-containing protein 1) (Sodium/hydrogen exchanger-like domain-containing protein 1) (Solute carrier family 9, subfamily B member 1) (Q4ZJI4)
Organism: Homo sapiens (Human)
Function: Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q8C0X2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Solute carrier family 9 member C1
Sequence:
MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAQEETKTVLSDTEEIKPQTKKETYISCPLRGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLVPPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQEKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLMCFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILITAPNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH
Protein: Stearoyl-[acyl-carrier-protein] 9-desaturase 6, chloroplastic (Stearoyl-ACP desaturase 6) (EC 1.14.19.2) (Acyl-[acyl-carrier-protein] desaturase 6) (Q84VY3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Oleoyl-acyl carrier protein thioesterase 1, chloroplastic
- Palmitoyl-acyl carrier protein thioesterase, chloroplastic
- Enoyl-[acyl-carrier-protein] reductase, chloroplastic
- Oleoyl-acyl carrier protein thioesterase 2, chloroplastic
- Enoyl-[acyl-carrier-protein] reductase, mitochondrial
- Rhodanese-like domain-containing protein 17
- At5g66985
- Delta
- Hydroxyproline-rich glycoprotein family protein
- Acyl-lipid omega-3 desaturase
Sequence:
MLAHKSLLSFTTQWATLMPSPSTFLASRPRGPAKISAVAAPVRPALKHQNKIHTMPPEKMEIFKSLDGWAKDQILPLLKPVDQCWQPASFLPDPALPFSEFTDQVRELRERTASLPDEYFVVLVGDMITEDALPTYQTMINTLDGVRDETGASESAWASWTRAWTAEENRHGDLLRTYLYLSGRVDMLMVERTVQHLIGSGMDPGTENNPYLGFVYTSFQERATFVSHGNTARLAKSAGDPVLARICGTIAADEKRHENAYVRIVEKLLEIDPNGAVSAVADMMRKKITMPAHLMTDGRDPMLFEHFSAVAQRLEVYTADDYADILEFLVGRWRLEKLEGLTGEGQRAQEFVCGLAQRIRRLQERADERAKKLKKTHEVCFSWIFDKQISV
Protein: Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein (Glycosyltransferase) (Q8GYH0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- Alpha-
- O-fucosyltransferase 14
- Rhamnogalacturonan I rhamnosyltransferase 1
- Probable xyloglucan galactosyltransferase GT14
- O-fucosyltransferase 5
- O-fucosyltransferase 36
- O-fucosyltransferase 23
- Rhamnogalacturonan I rhamnosyltransferase 1
- Probable galacturonosyltransferase-like 2
- Probable xyloglucan galactosyltransferase GT11
Sequence:
MTKKSQPQIPPPLSRRGGVVWLGWKLVIAFSVALCLLALLRIQLQYNSFTTLSFPLSVARSQTPLHKYSGDRPKLAFLFLARRDLPLDFMWDRFFKGVDHANFSIYIHSVPGFVFNEETTRSQYFYNRQLNNSIKVVWGESSMIEAERLLLASALEDHSNQRFVLLSDRCAPLYDFGYIYKYLISSPRSFVDSFLHTKETRYSVKMSPVIPEEKWRKGSQWIALIRSHAEVIVNDGIVFPVFKEFCKRCPPLGTNEAWLFLKQKRRNCIPDEHYVQTLLTMQGLESEMERRTVTYTVWNVSGTKYEAKSWHPVTFTLENSGPEEIKEIKKIDHVYYESESRTEWCKADSKPVPCFLFARKFTNEAAMRIVSEGLIGSSANKTL
Protein: Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) (A0A494C0D9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU364110}. Nucleus {ECO:0000256|RuleBase:RU364110}.
Interaction partners:
Sequence:
MVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE
Protein: Exocyst complex component 6 (Exocyst complex component Sec15) (Q54B27)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O54923}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54923}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q8TAG9}.
Interaction partners:
- Exocyst complex component 4
- Exocyst complex component 2
- Exocyst complex component 1
- Exocyst complex component 5
- Exocyst complex component 8
- Exocyst complex component 3
- Exocyst complex component 7
- Protein transport protein sec1
- Ras-related protein Rab-11A
- Vacuolar protein sorting-associated protein 54
Sequence:
MSNKKQKEEINTAGGSVILKTMVRDKDKEQKEEKREKKEKKRLEKKEAENVKKEKKKEKKELKKIGKAGRSGSITSDSSTHSGAQEFDSYGNDSNGGGGGLSASIDSNGLSSSGQPMQTRHLEKEVGEKQGIYSLSSQDRSSSLPHSSQDDQAKPLITESEIFSSESFLIAVSDTDHLGPAIKSVFENNKEKEVIKILNAYIAQKDLDIEKICGENHEGFINSVTAFLGLKGENLDLKQDVINLNYELQEIGRKYVTKAEELFAYKQIKDNIKRTKEVLNNCQYAILLGMKVDEYVQQKKYYQAIKNMDQLHNVYLKKLSDFQFARNMDYNIPVLKEKIKKLVKDEFNQWMVEIKEKSAVIGKLGMIQTSKKLLKEREINPLKIKTTFGENEQIWDKILDIPPIINSSSIGSLALYPTLNSPVTAPIYSPNSGKTPSSFGFNKQINEKDLKEDINQFSPFDESDIQFHPLYQCLFIHASIGQLEEFQAYYTLNRLLQFQLVIQPKESGQVWELFLQQILGYFMVESKVIDSTEPFLSKTTINDSWNSALVKVTSVLQELFTHCVDTQPLIAFKKFVLIFTNTMSFYSYHVQPLYYFLDTMKEKYCQFSIKEAVERFTIILERDSHCSLIIESLEEYKSLILANKLDILERQQLRQLQNSLNNNQFQFGDKNLNNNNNNDDDDDYFDEDENEDDKISKRLPKSFLFSKMVPQFYTLIKKFISEFYEFSDQLTENENFIIRSTDTLIKKINEVLYSYLTQSQAVPQVIQLVINLQHLISGCSFFKDYLNSLILGEDYQKNQSIVNETNKVILNSQNLLYTTKSHGEKLIIKLCEQKIEDLMSSAANIEWFPQNAIDDRPRDYIIDVCTFLEVTLPFISPLSQNLKEEFITKAFKNISESLFSLIYDDQLKKLNLQGVKSFDADLKYIETYVKEKANEKERTTTTSRNMVGYFVELRQLTNFLLSDNPEDFVDPKIKAKHYNLITNIPQLLNILNKYKEESKGFTTSKEIKDRNKKIADAIKKIKDSL
Protein: Eukaryotic translation initiation factor 6 (eIF-6) (B4 integrin interactor) (CAB) (p27(BBP)) (O55135)
Organism: Mus musculus (Mouse)
Function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
Subcellular location: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Interaction partners:
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein uL18
- mRNA turnover protein 4 homolog
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein uL14
- 60S ribosomal export protein NMD3
- Ribosome biogenesis protein NSA2 homolog
- Large ribosomal subunit protein eL24
- GTP-binding protein 4
Sequence:
MAVRASFENNCEVGCFAKLTNAYCLVAIGGSENFYSVFEGELSDAIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAKPSTIATSMRDSLIDSLT
Protein: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-) (Q86SW4)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
AVPIPLCVSGVQPLALRLPEGELPSRETFPACINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQP
Protein: Potassium channel toxin alpha-KTx 11.3 (Parabutoxin-10) (PBTx10) (Q6WGI9)
Organism: Parabuthus granulatus (Granulated thick-tailed scorpion)
Function: Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity.
Subcellular location: Secreted {ECO:0000269|PubMed:14561751}.
Interaction partners:
Sequence:
DEEPKETCSDDMCVIYCKGEEFSTGACDGPQKCKCS
Protein: Adrenodoxin homolog, mitochondrial (Mitochondrial ferredoxin) (Q12184)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for Fe-S cluster incorporation into mitochondrial and cytosolic apoproteins. May be part of a novel electron transport chain.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:10375636, ECO:0000269|PubMed:10655482}.
Interaction partners:
- Probable NADPH:adrenodoxin oxidoreductase, mitochondrial
- Cysteine desulfurase, mitochondrial
- Iron sulfur cluster assembly protein 1, mitochondrial
- Protein ISD11
- Heme A synthase COX15
- Frataxin homolog, mitochondrial
- Cytosolic Fe-S cluster assembly factor NAR1
- Bud site selection protein 22
- Iron sulfur cluster assembly protein 2, mitochondrial
- Protoheme IX farnesyltransferase, mitochondrial
Sequence:
MLKIVTRAGHTARISNIAAHLLRTSPSLLTRTTTTTRFLPFSTSSFLNHGHLKKPKPGEELKITFILKDGSQKTYEVCEGETILDIAQGHNLDMEGACGGSCACSTCHVIVDPDYYDALPEPEDDENDMLDLAYGLTETSRLGCQIKMSKDIDGIRVALPQMTRNVNNNDFS
Protein: Amino acid ABC transporter, ATP-binding protein (Q72DG1)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Putative glutamine transport system permease protein GlnP
- Amino acid ABC tranporter, permease protein, His/Glu/Gln/Arg/opine family
- Putative glutamine transport system permease protein GlnP
- Amino acid ABC transporter, periplasmic amino acid-binding protein
- Putative glutamine transport system permease protein GlnP
- Amino acid ABC transporter, permease protein, His/Glu/Gln/Arg/opine family
- Glutamate/aspartate import permease protein GltK
- Amino acid ABC transproter, permease protein, His/Glu/Gln/Arg/opine family
- ABC transporter, permease protein, His/Glu/Gln/Arg/opine family
- Amino acid ABC transporter, permease protein, His/Glu/Gln/Arg/opine family
Sequence:
MTIISARNVNKYFYVPEELHALRDVSLDVAPGEVVVIIGPSGSGKSTFLRCLNRLEYADSGEILIEGRDILDPKCEINEVRAEVGMVFQSFNLFPHLSVLENVALAQMTVRKRSRAESEKKGMELLTKVGIADKHAVYPDQLSGGQQQRVAIARSLAMDPKIMLFDEPTSALDPEMVGEVLDVMRNLAREGMTMVVVTHEMGFAREVADRVVFMDHGAILEIATPKDLFTTGATHDRTKLFLSQIL
Protein: PDZ domain-containing protein (Q4GYF0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- T. brucei spp.-specific protein
Sequence:
MEKVATTASTAALRRGINKKEKEKGEVVDGGSARRKKGINAVEGGQSLGDSEARQRQLLLSRKDAVTPIPEVALRMFNIAMEDLCNKYLQDYYTAAGNLFLVHSRRLSPQTNGPRSSQQVQSQRHPEKVIQKISSVPVKTASSERPSQAPSRGCSTSFRSSRLSAGTAGAATITRSSQSIPLSIRRPTSLLSSSKVAQSRKDRSTCQGGTGTTEDINHTSASRNKASRSEFMDARTTAVSDERQRSRLFTMCSGTTSPSAGNSSRRWTAAGAEANQTHPSGASKTSANSPASPVPRIPISKVWKASVSSRTADRQLESPGRLTEPLRTRLYATDAEVSPEHRRQTSPSLLSRKHRESRASATPAKPEPPLNESSRHPRASSATTPRMSRVSASSTPQFSRRSLVTTPRVPHRPSVRRAGESPHTSVSRLTTPRQLRPCTHCSGRGIEGGIIGLVSSTRSADLAKESVDCSTEYRLEWSCTNSCAQSYTQQTSSQRRSTALVGPNRSTLTGVFEWPVGRHTPLSRPYSQTAVPRGSITRDGGCPTTDVTPPSPLVRSLTLISESVNETPAEYISRHFSSCVINSVLECVRVKMGGRKSDEADPRADELNGSDSSDDTDKIGNGDATNDISLGLQKGDLLLECNGQPLSGAASLQEIIRKALLCDNNTVLLRVLRGADSIAVRETLLKDSSAVRIVEPVM
Protein: E3 ubiquitin-protein ligase Bre1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Bre1) (dBre1) (Q9VRP9)
Organism: Drosophila melanogaster (Fruit fly)
Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It thereby plays a central role in histone code and gene regulation. Required for the expression of Notch target genes in development by affecting the levels of Su(H) in imaginal disk cells and stimulating the Su(H)-mediated transcription of Notch-specific genes.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2-17 kDa
- Histone-lysine N-methyltransferase Set2
- RNA polymerase-associated protein Rtf1
- Histone-lysine N-methyltransferase SETD1
- Ctr9, isoform A
- Hyrax
- Histone H2B
- RNA polymerase II-associated factor 1 homolog
- WW domain-containing adapter protein with coiled-coil homolog
- Histone H2A.v
Sequence:
MSKRSADDATGSSCLVAAAAAGQPPIKKVHFEPHLIGPVSTLEEMDIKVLEFQNKKLAQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAETADELENRNENEVTTSFLAQLSTWDKEELDEKLANRVQVSKRAVAKIVQVIDRLMQRNEKITHVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQTHIEIMSENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCRNDKLENHLAEAIEKLKAYHQIYGDPNKSTNSAKTPTTTGSGGATTSVNSQLLEELQKELEEYRELANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLDETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQNMAANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGNKLQAATGAAGEEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEADDEASGKDVKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESETVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADEEALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQIEAMHIVLRKLEEKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMIEEIREYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYLQ
Protein: Probable cytochrome P450 12d1 distal, mitochondrial (EC 1.14.-.-) (CYPXIID1) (Q7KR10)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion membrane {ECO:0000305}.
Interaction partners:
Sequence:
MNTLSSARSVAIYVGPVRSSRSASVLAHEQAKSSITEEHKTYDEIPRPNKFKFMRAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVSQKMLKENQDALEKRRQAGEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRPFKTMFLMEPAITFPFKFTDIEQ
Protein: E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2 (EC 2.3.2.27) (RING finger protein 2) (RING-type E3 ubiquitin transferase rfp2) (Q9UT72)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:17762864, ECO:0000269|PubMed:17762865}.
Interaction partners:
- E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8
- Ubiquitin-like protein pmt3/smt3
- E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1
- Ubiquitin-conjugating enzyme E2 4
- Rik1-associated factor 1
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 1
- Histone-lysine N-methyltransferase, H3 lysine-9 specific
- Rik1-associated factor 2
- Anaphase-promoting complex subunit 3
Sequence:
MNLHGLELPGRDQRLSPEVIDLTEDIEDDGADVSEVTLLDLTRIPEFQPRRRIRTSRNHLDANLSNVPTINSIPSPVTRPPVAVGGGIFYGARRTRNRSQTQRRTLLENGFRNSRKKAQDSSNSIAERVSPPPGFCYDVHPHNNIACAKCGNELVSDEKKSIFAAKCGHLFCSTCAKELRKKTVPCPVQHCRKRITKKFIFPLYL
Protein: Uncharacterized protein (Q386D3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKARRAARGSLKEPKQIPYTKSSPFVASAQARGAGNLLWKKPMAFLSRMVSVVMEKVRSSPSKHLKYGDILRDIPFHVHNRIISYFSTHPTLCVEVFGVSHGQCIRFTHGPWARQTAIVIGVRGGKLWVLDKDGPVMARPLFTIEQHDWEKLLPDEELLKRLKEGLEVARRGAELDYDPEQREFLQKAPDLFVEVVDDDMDYANAGSSAALSSRGSCAKTIRSERYTSNVNPVRGMDDGIFELPERSRKRVILVPQIAQVTGDAGWAGEGLVVVNGGGVRSFTSSLSASVLL
Protein: Heme transporter hrg-1 (Heme-responsive gene 1 protein) (CeHRG-1) (Q21642)
Organism: Caenorhabditis elegans
Function: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18418376}; Multi-pass membrane protein {ECO:0000269|PubMed:18418376}. Lysosome membrane {ECO:0000269|PubMed:18418376}; Multi-pass membrane protein {ECO:0000269|PubMed:18418376}.
Interaction partners:
- Heme Responsive protein
- Multidrug resistance-associated protein 5
- Cadmium-inducible lysosomal protein CDR-5
- GST_C_6 domain-containing protein
- NADPH-dependent diflavin oxidoreductase 1
Sequence:
MHQIYSSDVSSITSKSSIAKAEIITMEEEQQRQSCCTWFHSLKVQIWIAWLGVSAGVMAGTVFAIQYQNWIAVTMCFISSGFATLVLHLHLAYKKTQMAGWSETRLRCLAAVGATVSFLSFIAMVFCLVVAGIEHQTLDKQGLMGANLWIAAVWFFMTSKWSALTWRFARKYRAFCEESQPLLAAAPPEYSVTI
Protein: Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) (O75530)
Organism: Homo sapiens (Human)
Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Subcellular location: Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.
Interaction partners:
- Histone-lysine N-methyltransferase EZH1
- Protein Jumonji
- Zinc finger protein AEBP2
- Histone-binding protein RBBP4
- Histone-binding protein RBBP7
- Polycomb protein SUZ12
- Histone-lysine N-methyltransferase EZH2
- E3 ubiquitin-protein ligase RING2
- Polycomb complex protein BMI-1
- Polyhomeotic-like protein 1
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR