wanglab/gogpt-training-data huggingface dataset:
Protein: Klra21 protein (Q6P3B5)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MQSDIKLKEEMSTTESIDCRPSNELLEYIKREQERWNSESKTVLDSSRDTGRGVKYWFCYGTKCYYFIMNKTTWSGCKANCQHYSFPIVKIEDEDELKFLQRHVIPESYWIGLSYDKKKKEWAWIDNGPSKLDMKRKMNFTSRGCVFLSKARIEDTDCNTPYYCICGKKLDKFPD
Protein: Plc2p (Q5A0L4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Fgr22p
- Phosphatidylinositol 3-kinase VPS34
- 1-phosphatidylinositol 4-kinase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphatidylinositol 4-kinase PIK1a
- Phosphatidylinositol 4-kinase
- Phosphatidylinositol-3-phosphatase
- Phosphatidylinositol-3-phosphatase
- Lysophospholipase
- Phospholipase
Sequence:
MVDYKTWLKDIDNNTRISKLSIPGTHNSAACHTALPSVQCQGASVTEQLEHGVRFLDIRVGKLFVGNDVKDLQVIHGKFPVKIPFPLKLKDTLEEVYKFLAHNSSETVIVSIKQEGSDDWDNSQDEFGKLIWDRYVNPNKDRWYLNTDIPKLGDARGKAILFRRFGVQDEQLKKQFGFSASSWTYNTTNDDRGQFVVQDFCEVNTADDLPKKIDYVKDLAKRAQDYTSKGDDKVFLNFTSASNFFDQSCWPQPIAEAMIKGNIQETFHKGVGIIVLDYAETDNWKLPEALIDTNF
Protein: Syndecan (Q66I66)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}.
Interaction partners:
Sequence:
MRNFWMILTLGLTAFLSGERISVSAAKSPSTTDDLYLEEAGSGGYPEDDDDFSSGSGSGAGEVIEDPVTVNTLFFVPKAEPTQDSTKDFTPKVETVTSQDAPKDSKKRRIEVAVPVTEDSRRNPVTSTTSIPRPPMDPQDVQSENLFQRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSGAAYQKAPTKEFYA
Protein: Clathrin heavy chain (A0A087WVQ6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side {ECO:0000256|PIRNR:PIRNR002290}.
Interaction partners:
Sequence:
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKGIKESGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM
Protein: DNA 5'-3' helicase (EC 5.6.2.3) (D3ZEG9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIH subunit 2
- General transcription factor IIH subunit 1
- General transcription factor IIH subunit 3
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIE subunit 1
- General transcription factor IIH subunit 4
- Cyclin-H
- Transcription initiation factor IIE subunit beta
- Cyclin-dependent kinase 7
Sequence:
MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDTHGRQVPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTITNPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL
Protein: MHC class II H2-M beta 2 chain (Q31112)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAALWLLLLVLSLHCMGAGGFVAHVESTCVLNDAGTPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISNILNEQESLIQRLQNGLQDCATHTQPFWDVLTHRTRPPSVRVAQTAPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH
Protein: Taste receptor type 2 member 110 (T2R110) (mT2r57) (STC 9-1) (Q7M712)
Organism: Mus musculus (Mouse)
Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Taste receptor type 2 member 16
Sequence:
MFSQIISTSDIFTFTIILFVELVIGILGNGFIALVNIMDWTKRRSISSADQILTALAITRFLYVWFMIICILLFMLCPHLLTRSEIVTSIGIIWIVNNHFSVWLATCLGVFYFLKIANFSNSLFLYLKWRVKKVVLMIIQVSMIFLILNLLSLSMYDQFSIDVYEGNTSYNLGDSTPFPTISLFINSSKVFVITNSSHIFLPINSLFMLIPFTVSLVAFLMLIFSLWKHHKKMQVNAKPPRDASTMAHIKALQTGFSFLLLYAVYLLFIVIGMLSLRLIGGKLILLFDHISGIGFPISHSFVLILGNNKLRQASLSVLHCLRCRSKDMDTMGP
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A1ZBC4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- histone deacetylase
Sequence:
MATTPTAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPNGTYPVGAALPMGMSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIHRVVHSKLPTVQEGATIGRYSPVRRASEGSKSQFQGPLQECQSLQKGIAQRNFLVAPSPPLLENSISLPGSPIHGKPGMGLQLALRRGHDIEVPPEAIKNLMPALDRLVKEQRVSFEIANKIISTHVVPMDLAPLLGLAAHASSAAAVSGGHLDQSHFTHLQQQQQQQHMLSFSVSPLSMPQGGAVNASLTSAKQMFGQPICGYTQYQPMTLALQPQHQQQLVGQFSSINLGASNSNSSSGCQSPVFSTSFSGSCSPNPYLPGAAGGSSPLHQITKGISGLSTGCAGGSITRGTSAASEGAAAAAAANQPLDLSMDVCGGVMDQQPTDYAATNWFMPTASYYDMKPLNLSPAQPVRVVPTPPASPNLCIIQEENGNGQMCHTISTGTPYAGCTGGITPQICLTDVQGSEITLVALSSDNSRDSEDSLEQHTPVMSLQGLIITEPSSDMPSITRGIGRKASLDCDSGAGSHCPVASGSSHANQSQTQAQTEAQCRRGSDKSLGFSDDSLSNDSNNLSPCQEPSASSGFKSDSHSEMGDHTECGHLTPDSMCDSRRMSDEMCYEVPLPHECSNLDSTRILEMVKQTIDSTMPPKGFVLHKGSISSEDSGAESRHSSASNASTSNPLACEAASLLASHSGYGEPTTNLSLEYSGGLQIELQVCEGRSRDHHGAGKGIKLRRISGDQFEYGKICQQLISTITMQQVAG
Protein: B2 bradykinin receptor (B2R) (BK-2 receptor) (P30411)
Organism: Homo sapiens (Human)
Function: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane {ECO:0000305|PubMed:1314587}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Kininogen-1
- Angiotensinogen
- Guanine nucleotide-binding protein G
- Type-1 angiotensin II receptor
- B1 bradykinin receptor
- Guanine nucleotide-binding protein G
- Endothelin-1
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-15
- Angiotensin-converting enzyme
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
Protein: Mitochondrial protein PET191 (Q02772)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the assembly of cytochrome c oxidase.
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:11914276, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:22984289}. Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery.
Interaction partners:
- Cytochrome c oxidase copper chaperone
- Mitochondrial intermembrane space import and assembly protein 40
- Mitochondrial import inner membrane translocase subunit TIM9
- Cytochrome c oxidase-assembly factor COX23
- Mitochondrial FAD-linked sulfhydryl oxidase ERV1
- Protein PET117
- Cytochrome c oxidase subunit 12, mitochondrial
- Mitochondrial intermembrane space cysteine motif-containing protein MIX17C motif protein of 17 kDa)
- Cytochrome c oxidase assembly protein COX11
- COX assembly mitochondrial protein
Sequence:
MVASCKDQKKAVAICLQRSPCVMIERHNPQECLDNPELNKDLPELCIAQMKAFLDCKRGIVDMTKRFTGNAPLSTGKYDQQYENLCKGKFDPREEMEKLKLLNSQQKD
Protein: AT3g13990/MDC16_11 (Dentin sialophosphoprotein, putative (DUF1296)) (Q8L7T4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Spc97 / Spc98 family of spindle pole body
- Early nodulin-like protein 15
- SKU5-similar 6
- Uncharacterized protein At4g14620
- At3g26990
- At3g16760
- AT5G14540 protein)
- At5g09670
- Early nodulin-like protein 19
- CCT motif family protein
Sequence:
MVTGSRTSGNRGVGLDDEAKKMIQSIKEVVDSHSDADIYTALKEANMDANEAVEKLIHQDPFHEVKRKRDRKKEDTVFVEPANIKKPLENVTSEVKVRTQPEHNVRRGGYSRNFFPRNAAQRNASPRNPATGSNKEFRVVRDNRSNPNVDEELKHSSAQSSGSNINKVVATVNKLGSRGGLGNRNSSGAQDSTDECNAPADARLRQAEIRPLHCPVNKELGGVTLPSTNSVLGVYSSSKDPVHVPSPVSRSSPVGAIKREVRGGGLGGKPSENVGKDPSVPSFSGSSIRKNGPPNAHRPSSPTSKIDHSRTTARESVMPSGVEKNRSYLNRQRGNRGSQYARTQQVGGHTKGASQNKEWKPKSNQKPVGHNPGVIGTPTKSQARRPADNSINVETEAVKLQNKLSHVHISESQNVIIADHIRVPETDRCQLTFGSFVQEFNSSRNSESAFEESHSSEEVRESDRSSPVTCPEASADGPGVLPITIDDHVRVSRSDSPVSAVSEPQLPEQKETHRSDNLDAYSGIELLNRNGPPYTPLEFEQQQDPPELQKFSQAYDNHGSYEFPYFSPAMDETVRVQGLPSPHEQGLSAHMLNNAPPSTIPMLQQQQQASMQQMYPQVHVSHFPNLMPYRQFLSPVYVPQMPMPGYSGNPAAYAHPSNGNSYVLMPGGGSHLGSNGVKYGIHQQYKPVPTGGPAGFGTYNNPNGYPTNPPNVVGNATGLEDPSRMINKHGNIYVPNPQAETSEIWMQNPRDLSSLQSPYYNVAGQSPHGAYLSSHTAHQSFNPTAQSSHMQFQGLFHPSQPGTMANPHHMGPGLSGNVGVGVVPSPPPSQIGTYQQSQLGHPNWPSNF
Protein: Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Q6DHQ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Transmembrane phosphatase with tensin homology
- Otopetrin 2.
- Potassium voltage-gated channel subfamily A member 2
Sequence:
MSRYLKHFTAVGDNKSAVPTWHEEDTSHHVTTLHDAPDGLEVSTGQHLGQLSFRDSLRKLYSTERFQIVVVCLVVLDAIFVLCELLIDLSIIEADHHRIAPQVFHYLSLALLTFFMVELAGKIFAYRLEFLHHKFEVFDGIVVVVSFILDIIYISKEDAFDAMGLLILLRLWRVARIINGILVSVQNRANHRVEKLKEINESLVHQVNELKEQNTKMDQENVRLRALLKDHSIDF
Protein: Macrolide export protein MacA (P75830)
Organism: Escherichia coli (strain K12)
Function: Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, MacA binds tightly rough-core lipopolysaccharide (R-LPS), suggesting that the system could also transport R-LPS or a similar glycolipid.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:11544226, ECO:0000269|PubMed:17214741}; Single-pass membrane protein {ECO:0000269|PubMed:11544226, ECO:0000269|PubMed:17214741}; Periplasmic side {ECO:0000269|PubMed:11544226, ECO:0000269|PubMed:17214741}.
Interaction partners:
- Macrolide export ATP-binding/permease protein MacB
- Outer membrane protein TolC
- Multidrug export protein EmrA
- Probable aminoglycoside efflux pump
- Multidrug export protein AcrF
- Multidrug efflux pump subunit AcrB
- Multidrug export protein EmrB
- Probable multidrug resistance protein EmrK
- Multidrug resistance protein MdtB
- Multidrug resistance protein MdtC
Sequence:
MKKRKTVKKRYVIALVIVIAGLITLWRILNAPVPTYQTLIVRPGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQAENQIKEVEATLMELRAQRQQAEAELKLARVTYSRQQRLAQTKAVSQQDLDTAATEMAVKQAQIGTIDAQIKRNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSAMLVKAQVSEADVIHLKPGQKAWFTVLGDPLTRYEGQIKDVLPTPEKVNDAIFYYARFEVPNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALGDPVGDNRYKVKLLRNGETREREVTIGARNDTDVEIVKGLEAGDEVVIGEAKPGAAQ
Protein: Myocyte-specific enhancer factor 2A (Q2MJT0)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:17367767}.
Interaction partners:
- Mitogen-activated protein kinase 14
- Myocyte-specific enhancer factor 2D
- Myocyte enhancer factor 2B
- Homeobox protein Nkx-2.5
- Nuclear factor of activated T-cells, cytoplasmic 4
- Nuclear factor of activated T-cells, cytoplasmic 3
- Nuclear factor of activated T-cells 1
- Nuclear factor of activated T-cells 2
- Myoblast determination protein 1
- mitogen-activated protein kinase
Sequence:
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINEEFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPNGAGNGPVGNGFVDSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVVIPPSSKGMMPPLNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNINIKTEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT
Protein: Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) (O43521)
Organism: Homo sapiens (Human)
Function: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Subcellular location: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform BimEL]: Mitochondrion. Note=Translocates from microtubules to mitochondria on loss of cell adherence.; SUBCELLULAR LOCATION: [Isoform BimL]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform BimS]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform Bim-alpha1]: Mitochondrion.
Interaction partners:
- Induced myeloid leukemia cell differentiation protein Mcl-1
- Bcl-2-like protein 1
- Apoptosis regulator Bcl-2
- Dynein light chain 1, cytoplasmic
- Bcl-2-related protein A1
- Bcl-2-like protein 2
- Bcl-2 homologous antagonist/killer
- Apoptosis regulator BAX
- Phorbol-12-myristate-13-acetate-induced protein 1
- Bcl-2-like protein 10
Sequence:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH
Protein: Phospholipase A1-Igamma3, chloroplastic (EC 3.1.1.-) (DAD1-like lipase 2) (Q9C8J6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acylhydrolase that catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position. Moderate activity toward phosphatidylcholine (PC), monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and triacylglycerol (TAG).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:19527719}.
Interaction partners:
- Digalactosyldiacylglycerol synthase 1, chloroplastic
Sequence:
MASLSLPITLKNPRFFSSSPQNIFKTQPQTLVLTTKFKTCSIICSSSCTSISSSTTQQKQSNKQTHVSDNKREEKAEEEEEEKEVSLREIWREVQGCNNWEGQLDPMNNHLRREIIRYGEFAQACYDSFDFDPHSKYCGSCKYHPSDFFLNLDLHLHKGYTITRYLYATSNINLPNFFQKSKLSSIWSQHANWMGFVAVATDEEEVSRLGRRDIVIAWRGTVTYLEWIYDLKDILCSANFGDDPSIKIELGFHDLYTKKEDSCKFSSFSAREQVLAEVKRLIEYYGTEEEGHKTSITVTGHSLGASLALVSAYDIAELNLNHVPENNYKIPITVFSFSGPRVGNLRFKERCDELGVKVLRVVNVHDKVPSVPGIFTNEKFQFQKYVEEKTSFPWSYAHVGVELALDHKKSPFLKPTKDLGCAHNLEALLHLVDGYHGKDEEAEKRFCLVTKRDIALVNKSCDFLRGEYHVPPCWRQDENKGMVKNGDGQWVLPDRPLLEPHGPEDIAHHLQQVLGKVNDDNFKPTTT
Protein: Penicillin-binding protein 4B (PBP-4B) (PBP4b) (EC 3.4.16.4) (Penicillin-binding protein I) (O32032)
Organism: Bacillus subtilis (strain 168)
Function: Penicillin-binding protein with an unknown catalytic activity. Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactamase inactivates the PBPs by acylating an essential serine residue in the active site of these proteins, thereby interrupting normal cell wall synthesis.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized membrane protein YrrS
- Stage V sporulation protein E
- Penicillin-binding protein 2D
Sequence:
MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLIQESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGMSEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASHTIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGNPLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVLGIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYGEPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLYHETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGEKRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQDLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTNSVFYDIVKKVHEIEINQK
Protein: Spnb3 protein (Q68FM2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
EIQGHEPRIADLKERQRTLGTAAAGPELAELQEMWKRLSHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYASLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSKDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSTQVQQVQDDGQRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGQELLARSHYAAEEISEKLSQLQSRRQETADKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEERENERKRKREEEERRKQPPTSEPMASQPEGSLVDGQRVPDTAWDGTQSKLPPSTQAPSVNGVCTDTDSSQPLLEQQRLEQSNVPEGPGSGTGDESSGPRGERQTLPRGPAPSPMPQSRSSEAAHGATLPTRGPELSAQEQMEGMLCRKQEMEAFNKKAANRSWQNVYCVLRRGSLGFYKDARAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSAPGESEEPVVPSASRGLTRAMTMPPVSQPEGSIVLRSKDGREREREKRFSFFKKNK
Protein: Uncharacterized oxidoreductase C115.03 (EC 1.-.-.-) (O42896)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MPPIKTAVLGTGVSAFVFHFPFLEALPSKFEIYACLERRATVTQSKARSAYPNILVYTNLDELLADVNIELVVVSLPPNVHSEIVKKALNAGKHVVCEKPFTPTYEEAKELYELAESKSLLLAIYQNRRWDGDFLTAKKIIESGRLGQVVEFESHFDRYRLGRKSGSWKDEPRPGNGMVYGIGSHLIDQAVSLFGTPYSVTAKLEAQRQIPPLEVEDYFRIILHYPAKGNKLPINVILSSTNVSCGCEMRFCIKGTRGSFMKFGFDPQESQLHSGMKPNDHGFGTDRFELYGNLWTVPLDADVKALPEPTKITVPTVQGNYRDFYDAVFEEILKKANEFPIKSDQVLAVEKIMEAAYKSSESSSSIQL
Protein: Cold shock-like protein CspC (CSP-C) (P0A9Y6)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Protein YobF
- Elongation factor Tu 1
- DNA topoisomerase 4 subunit A
- Cell division topological specificity factor
- Uncharacterized protein YaeQ
- Elongation factor Tu 2
- Ribosome-associated inhibitor A
- Ribonuclease E
- Protease 7
- Ribosome modulation factor
Sequence:
MAKIKGQVKWFNESKGFGFITPADGSKDVFVHFSAIQGNGFKTLAEGQNVEFEIQDGQKGPAAVNVTAI
Protein: Small GTPase (Q54EY3)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- F-box domain-containing protein
- Nuclear exosome regulator NRDE2
- Probable serine/threonine-protein kinase DDB_G0282777
- Probable serine/threonine-protein kinase PLK
- Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
- Uncharacterized protein
- Putative mitotic check point protein BUB2
- Serine/threonine-protein phosphatase 2A catalytic subunit A
- Rac guanine nucleotide exchange factor B
Sequence:
MSEEQFTGSSDTKKNNVVVKVGMVGDSQIGKTSLMVKYVEGTFDEDYIQTLGVNFMEKTISIRGTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLSRKSTLNSVKEWYRQARGFNKTAIPFLIGTKFDVFATKPIEEQEEITKQARKFASAMKSPLIFCSTSHSINVQKIFKIVISKAFDLNCTIPKVVGVGEPLLEY
Protein: EFR3 homolog B (H7BXG9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
FVKFANIEEDTPSYHRSYDFFVSRFSEMCHSSHDDLEIKTKIRMSGIKGLQGVVRKTVNDELQANIWDPQHMDKIVPSLLFNLQHVEEAESRSPSPLQAPEKEKESPAELAERCLRELLGRAAFGNIKNAIKPVLIHLDNHSLWEPKVFAIRCFKIIMYSIQPQHSHLVIQQLLGHLDANSRSAATVRAGIVEVLSEAAVIAATGSVGPTVLEMFNTLLRQLRLSIDYALTGSYDGAVSLGTKIIKEHEERMFQEAVIKTVGSFASTLPTYQRSEVILFIMSKVPRPSLHQAVDTGRTGENRNRLTQIMLLKSLLQVSTGFQCNNMMSALPSNFLDRLLSTALMEDAEIRLFVLEILISFIDRHGNRHKFSTISTLSDISVLKLKVDKCSRQDTVFMKKHSQQLYRHIYLSCKEETNVQKHYEALYGLLALISIELANEEVVVDLIRLVLAVQVIETRKKEAPYMLPEDVFVERPRLSQNLDGVVIELLFRQSKISEVLGGSGYNSDRLCLPYIPQLTDEDRLSKRRSIGETISLQVEVESRNSPEKEERVPAEEITYETLKKAIVDSVAVEEQERERRRQVVEKFQKAPFEEIAAHCGARASLLQSKLNQIFEITIRPPPSPSGTITAAYGQPQNHSIPVYEMKFPDLCVY