wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor EC (TFE-C) (Class E basic helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L) (O14948)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11467950}.
Interaction partners:
- Cathepsin K
- Transcription factor E3
Sequence:
MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVIEDIIGMESSFKEEGADSPLLMQRTLSGSILDVYSGEQGISPINMGLTSASCPSSLPMKREITETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLGTVDLGAHVTKQQSHPEQNSVDYCQQLTVSQGPSPELCDQAIAFSDPLSYFTDLSFSAALKEEQRLDGMLLDDTISPFGTDPLLSATSPAVSKESSRRSSFSSDDGDEL
Protein: Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (A0A0H3L5C8)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Interaction partners:
Sequence:
MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFARNGEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRDAEAYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKGEKEQRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKGTSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRITQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTIPTKRSETFTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTFDIDANGIVHVTAKDKGTGKENTIRIQEGSGLSKEDIDRMIKDAEAHAEEDRKRREEADVRNQAETLVYQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDISAIKSAMEKLGQESQALGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREAK
Protein: Chromosome transmission fidelity factor 18 (E7EXA6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEDYEQELCGVEDDFHNQFAAELEVLAELEGASTPSPSGVPLFTAGRPPRTFEEALARGDAASSPAPAASVGSSQGGARKRQVDADLQPAGSLPHAPRIKRPRLQVVKRLNFRSEEMEEPPPPDSSPTDITPPPSPEDLAELWGHGFSEAAADVGLTRASPAARNPVLRRPPILEDYVHVTSTEGVRAYLVLRADPMAPGVQGSLLHVPWRGGGQLDLLGVSLASLKKQVDGERRERLLQEAQKLSDTLHSLRSGEEEAAQPLGAPEEEPTDGQDASSHCLWVDEFAPRHYTELLSDDFTNRCLLKWLKLWDLVVFGHERPSRKPRPSVEPARVSKEATAPGKWKSHEQVLEEMLEAGLDPSQRPKQKVALLCGPPGLGKTTLAHVIARHAGYSVVEMNASDDRSPEVFRTRIEAATQMESVLGAGGKPNCLVIDEIDGAPVAAINVLLSILNRKGPQEVGPQGPAVPSGGGRRRRAEGGLLMRPIICICNDQFAPSLRQLKQQAFLLHFPPTLPSRLVQRLQEVSLRQGMRADPGVLAALCEKTDNDIRACINTLQFLYSRGQRELSVRDVQATRVGLKDQRRGLFSVWQEVFQLPRAQRRRVGQDPALPADTLLLGDGDAGSLTSASQRFYRVLHAAASAGEHEKVVQGLFDNFLRLRLRDSSLGAVCVALDWLAFDDLLAGAAHHSQSFQLLRYPPFLPVAFHVLFASSHTPRITFPSSQQEAQNRMSQMRNLIQTLVSGIAPATRSRATPQALLLDALCLLLDILAPKLRPVSTQLYSTREKQQLASLVGTMLAYSLTYRQERTPDGQYIYRLEPNVEELCRFPELPARKPLTYQTKQLIAREIEVEKMRRAEASARVENSPQVDGSPPGLEGLLGGIGEKGVHRPAPRNHEQRLEHIMRRAAREEQPEKDFFGRVVVRSTAVPSAGDTAPEQDSVERRMGTAVGRSEVWFRFNEGVSNAVRRSLYIRDLL
Protein: AH domain-containing protein (E1B6R5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTSETMRGVGEQAASLDACLRYFISSMETVYNQTITDTLHTIYNTESARIEYDVDRNDISAATNPPQGQLTKNLPVGATEKCEEKKAKYEKLKNDAKIKMRLLEENRISVVAAQLEKLQSALAAYYSGNAKLLEASVRELSFLQSPQPSFIPTM
Protein: Nitrilase blr3397 (EC 3.5.5.7) (Q89PT3)
Organism: Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
Function: Nitrilase that acts on various kinds of nitrile compounds such as aliphatic and aromatic nitriles. Has higher activity toward aliphatic nitriles compared to aromatic nitriles. Among the different substrates tested, has the highest activity toward hydrocinnamonitrile.
Interaction partners:
- nitrile hydratase
- Indoleacetamide hydrolase
- Indoleacetamide hydrolase
- Nitrile hydratase subunit beta
- Nitrilase bll6402
- Blr2084 protein
- Vanillin: NAD oxidoreductase
- aldehyde dehydrogenase
- Aldehyde dehydrogenase
- Betaine aldehyde dehydrogenase
Sequence:
MMDSNRPNTYKAAVVQAASDPTSSLVSAQKAAALIEKAAGAGARLVVFPEAFIGGYPKGNSFGAPVGMRKPEGREAFRLYWEAAIDLDGVEVETIAAAAAATGAFTVIGCIEREQGTLYCTALFFDGARGLVGKHRKLMPTAGERLIWGFGDGSTMPVFETSLGNIGAVICWENYMPMLRMHMYSQGISIYCAPTADDRDTWLPTMQHIALEGRCFVLTACQHLKRGAFPADYECALGADPETVLMRGGSAIVNPLGKVLAGPCFEGETILYADIALDEVTRGKFDFDAAGHYSRPDVFQLVVDDRPKRAVSTVSAVRARN
Protein: Exo-alpha-sialidase (EC 3.2.1.18) (Alpha-neuraminidase) (N-acylneuraminate glycohydrolase) (Q4WQS0)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Sialidase is able to release sialic acid from a wide variety of natural substrates including bovine salivary mucin, colominic acid, bovine fetuin, a serum glycoprotein containing both alpha-2-6 and alpha-2-3-linkages in a ratio of about 3:2, and glycoproteins and glycolipids from thermally denatured human lung epithelial cells. Does not show any trans-sialidase activity since it is able to remove terminal sialic acid residues but is unable to catalyze their transfer to the acceptor substrate. 2-keto-3-deoxynononic acid (KDN) is the preferred substrate and A.fumigatus can utilize KDN as a sole carbon source.
Interaction partners:
- Alpha-galactosidase
- alpha-galactosidase
- Alpha-galactosidase
- Probable alpha-galactosidase A
- Probable alpha-galactosidase D
- Probable alpha-galactosidase B
- Alpha-galactosidase
- DNA 3'-5' helicase
- Telomere-associated RecQ helicase, putative
- DNA 3'-5' helicase
Sequence:
MQSMRFMILALLVQFLPAWAINDPAKSAAPYHDEFPLFRSANMASPDKLSTGIGFHSFRIPAVVRTTTGRILAFAEGRRHTNQDFGDINLVYKRTKTTANNGASPSDWEPLREVVGSGAGTWGNPTPVVDDDNTIYLFLSWNGATYSQNGKDVLPDGTVTKKIDSTWEGRRHLYLTESRDDGNTWSKPVDLTKELTPDGWAWDAVGPGNGIRLTTGELVIPAMGRNIIGRGAPGNRTWSVQRLSGAGAEGTIVQTPDGKLYRNDRPSQKGYRMVARGTLEGFGAFAPDAGLPDPACQGSVLRYNSDAPARTIFLNSASGTSRRAMRVRISYDADAKKFNYGRKLEDAKVSGAGHEGGYSSMTKTGDYKIGALVESDFFNDGTGKNSYRAIIWRRFNLSWILNGPNN
Protein: Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (P45974)
Organism: Homo sapiens (Human)
Function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Interaction partners:
- Polyubiquitin-C
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-B
- Ubiquitin-ribosomal protein eL40 fusion protein
- Voltage-dependent T-type calcium channel subunit alpha-1H
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin carboxyl-terminal hydrolase 14
- Ubiquitin carboxyl-terminal hydrolase 7
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
- Zinc finger protein 629
Sequence:
MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVERHFNKTGQRVYLHLRRTRRPKEEDPATGTGDPPRKKPTRLAIGVEGGFDLSEEKFELDEDVKIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSASRKQEVQAWDGEVRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGVPLKPLFGPGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKKRQAEEEKMALPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGTGLQPGEEELPDIAPPLVTPDEPKGSLGFYGNEDEDSFCSPHFSSPTSPMLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLILPGSSGPGSTSAAADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHIDDLDAEAAMDISEGRSAADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKVCASEKPPKDLGYIYFYQRVAS
Protein: Uncharacterized SURF1-like protein Rv2235 (P9WGA7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable unidentified antibiotic-transport integral membrane ABC transporter
- Low molecular weight protein-tyrosine phosphatase A
- Tyrosine-protein kinase PtkA
- Uncharacterized protein Rv2239c
- Uncharacterized protein Rv2229c
- Uncharacterized protein Rv2240c
- Protoheme IX farnesyltransferase
- Bifunctional protein Rv2228c
- GTP cyclohydrolase 1 type 2 homolog
- Histidinol-phosphate aminotransferase Rv2231c
Sequence:
MPRLAFLLRPGWLALALVVVAFTYLCFTVLAPWQLGKNAKTSRENQQIRYSLDTPPVPLKTLLPQQDSSAPDAQWRRVTATGQYLPDVQVLARLRVVEGDQAFEVLAPFVVDGGPTVLVDRGYVRPQVGSHVPPIPRLPVQTVTITARLRDSEPSVAGKDPFVRDGFQQVYSINTGQVAALTGVQLAGSYLQLIEDQPGGLGVLGVPHLDPGPFLSYGIQWISFGILAPIGLGYFAYAEIRARRREKAGSPPPDKPMTVEQKLADRYGRRR
Protein: Prostaglandin F2 receptor negative regulator (CD9 partner 1) (CD9P-1) (Glu-Trp-Ile EWI motif-containing protein F) (EWI-F) (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD antigen CD315) (Q9WV91)
Organism: Mus musculus (Mouse)
Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- CD9 antigen
- CD81 antigen
- Tetraspanin-3
- CD151 antigen
- Ezrin
- Tetraspanin-18
- Tetraspanin-15
Sequence:
MGRPAPRPLLLALLSLAVCRGRVVRVPAGTLVRVVGTELVIPCNVSDYDGPSEQNFDWSFSSSGSSFVELASTWEVGFPAQLYRERLQRGDILLRRTANDAVELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTVQVKVLADALVVGPSSRPPPGLSLREGEPFELRCIASTTSPLHTHLALRWELHRGPVHRSILALSHEGRFHPGPGYEQRYHSGDVRLDTVGSDAYRLSVARALSADQGSYRCVVSEWITEQGSWQEIQEKAVEVATVVIQPTALQLAVPRTVSVTEGKDLDLSCNITTDRVDDVRPEVTWYFKKTPDTSLLASHMLARLDRDSLVHSSPHVALSHVDTRSYHLLVRDVSKENSGYYLCLVALWAPGHNRSWHKVAEAMSAPSGVSVTWLEPEYQVYLNASKVPGFSDDPTELQCRVIDTKRLEAGVRLTVSWYYRMTRRNDDVVASELLAVMDGDWTLRYGERSKQRAQDGEFIFSKEHTDTFNFRIQRTTEEDRGNYYCVVSAWTRQRNNSWVKSKDVFSKPVNIFWASEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLITAEKPVGDLSSPNETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAWSPIGGSLWREAATSLSNPIEIDFQTSGPTFNASVHSDTPSVTRGDLIKLFCIVTVEGAVLDPDDMAFDVSWFAVHSFGLDKAPVLLSSLDRKGVVTTGQRDWKSTVSLERVSVLEFLLQVHGSEDQDFGNYYCSVTPWVRSPTGSWQREAEIHSRPIFITVKMDVLNAFKYPLLIGVGLSTVIGLLSCLIGYCSSHWCCKKEVRETRRERRRLMSMEMD
Protein: Tubulin-folding cofactor D (Altered polarity protein 1) (Q10197)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a function in the folding of beta-tubulin. Microtubule-associated protein that is essential to direct polarized cell growth and to position the nucleus and septum to the center of the cell during mitosis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9450991}. Note=Microtubule-associated.
Interaction partners:
- Cell polarity protein alp21
- Tubulin-specific chaperone C
- ADP-ribosylation factor-like protein alp41
- Cell polarity protein alp11
- Tubulin beta chain
- Tubulin-specific chaperone A
- Carbonic anhydrase
Sequence:
MEEEESLEGIISIDESLITSRLSQILDDVLDDRSSSHSVEKLKDVAVKYLQFCQFQPTLLDKLLSKYVPNLASYLLKVKNIGKCNSITVILYQFCKIRGYKAVRVLFPVGVQYIKELYTLLNESSNNTWHFHYIVLLWLSQALNTPFPLNSLDDSLDVKKTIYTIAIKYLENSGIDKEASCLVLSRLFSRDDGLDLLLGFLHHCESSWFKRSIFYKIGCLFSLSSFLKICPRNDCLQTVDVAFQFLNVAREDLVGQENSALRKLLCKCYTRLGIVLLPVNSSPNWKYSISNPDSFFQLPDDSNEEVHIYLEVIVDFLLSSVSDIDSFVRWSAAKGLAKIISRLPWNLAEQVIDAIIELMTENMFLNPIENTVNISITSPLVWHGAILFFAKLAGAGLIKYSKCLHILPLIEVGLSYEVRYGTRVTGQSIRDASCYFVWSFYHCYSKSAIEGLQTNLILCLLQTVLFDNEINVRRAATAALFEVIGRHASIPDGLSLISHINYVSVTDISNCYGDLCMKVAHFPQFRSCVFQRLFTNLQHWDVKVQQLSAFSLRQLSIKYPKELSIYLPPILDYLSVGNADFIFGYTIGLASIIGGFLSISFPFDINRIHDLLSHKNLLSLKKFSRQQQTKIILGILKGIQQIFANDIRVDRAFFSEAFSVIIAAIDLQEETIIKDISDAYSVLVKFDDMEETLEVLLDYIRKCSTSKEARIVYIILQNLPNISFRYQKKICKLLLDIYPQLHSIDYQAPVANALQNIIPFTYEKTESIEEFVKELLQVCSNYLTDTRGDVGSWIRKPAMKAISSLLVKDSSGKKLSEDIVWCCISYIIRQTFDKIDSLRGLAYQALEQIRVHYLIRRCEALTNIINRIRNNPNMDGEVLNELNISLLEIPNLRLQAFYGITVFTADGFGSDLAVKCFEFYLSYVYQLEDSFKKSNSRYGKRDLLQLYIDILSSEDEIARFYFPIMKSFTSLLAYGCFTDFQNVKGMSKAIFIVQRRALTCKSPGGLSAILELYRTLFLSKNELLRHHALKYTANLLLNPIEKVRYQAADTLLYAKSIGLLTFLPNELNQKLLTLDWFVPVSQNATFVKQLRNIIQKQIDKLIADR
Protein: Uncharacterized protein CCDC197 (Coiled-coil domain-containing protein 197) (Q8NCU1)
Organism: Homo sapiens (Human)
Interaction partners:
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MAAMDTGQRADPSNPGDKEGDLQGLWQELYQLQAKQKKLKREVEKHKLFEDYLIKVLEKIPEGCTGWEEPEEVLVEATVKHYGKLFTASQDTQKRLEAFCQMIQAVHRSLESLEEDHRALIASRSGCVSCRRSATASRSSGGS
Protein: Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C) (Q00961)
Organism: Rattus norvegicus (Rat)
Function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:1350383, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:8428958}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14957}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q14957}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14957}.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 3B
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 3A
- Glutamate receptor ionotropic, NMDA 2D
- Disks large homolog 4
- Glutamate receptor ionotropic, kainate 1
- Glutamate receptor 1
- Glutamate receptor ionotropic, kainate 2
Sequence:
MGGALGPALLLTSLLGAWARLGAGQGEQAVTVAVVFGSSGPLQTQARTRLTSQNFLDLPLEIQPLTVGVNNTNPSSILTQICGLLGAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVRPTMVVIALNRHRLWEMVGRWDHGVLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDLTPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKPGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQLLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPSPDLTADSAQANVLKMLQAARDMVNTADVSSSLDRATRTIENWGNNRRVPAPTASGPRSSTPGPPGQPSPSGWGPPGGGRTPLARRAPQPPARPATCGPPLPDVSRPSCRHASDARWPVRVGHQGPHVSASERRALPERSLLPAHCHYSSFPRAERSGRPYLPLFPEPPEPDDLPLLGPEQLARREAMLRAAWARGPRPRHASLPSSVAEAFTRSNPLPARCTGHACACPCPQSRPSCRHLAQAQSLRLPSYPEACVEGVPAGVATWQPRQHVCLHAHTRLPFCWGTVCRHPPPCTSHSPWLIGTWEPPAHRVRTLGLGTGYRDSGVLEEVSREACGTQGFPRSCTWRRVSSLESEV
Protein: Guanylate kinase 3, chloroplastic (AtGK3) (EC 2.7.4.8) (GMP kinase 3) (Q94JM2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential for recycling GMP and indirectly, cGMP.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- GMP synthase
- Hypoxanthine phosphoribosyltransferase
- Adenine phosphoribosyltransferase 5
- Adenine phosphoribosyltransferase 4
- Nucleoside diphosphate kinase II, chloroplastic
- Adenine phosphoribosyltransferase 1, chloroplastic
- Adenine phosphoribosyltransferase 3
- Adenine phosphoribosyltransferase 2
- Nucleoside diphosphate kinase 1
- Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
Sequence:
MIRKLCSSFSRSIIFPNKPIFIPRSFPQPLRHSSALSYSSLKMTDTHIPGNPNSSPIQSPTKPESLRSLEFQLGSSFTADPIIPPPNQIVIVISGPSGVGKDAVINKLREVREGLHFVVTATSRPMRPGEVDGKDYFFVSRDQFLSMVENEELLEYALVYGEYKGIPKKQIQEFMAKGEDIVLRVDIQGAQTLRRILGNSAVFIFLVAESELAMVERLIDRKTESQEELLVRVATAREEVRHLKNFDYVVVNAKGRLDDAVNRVESIIDAEKSKVHQRIVRI
Protein: Kinesin-like protein (Q05AP4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MVKQTIEIFARVKPTKKPTSEYFADCDEQGGSLLFLVPRDAADGFINNKRENYKFRFQKVFDQTASQEEVFENIAKPVADNVLAGYNGTIFAYGQTGSGKTFTITGGAEHYNDRGIIPRTLSYLYRHFSMNNTMIYTTHISYLEIYNESGYDLLNPQHEASRLEDLPRVTIMEDPDQNIHLKNLSLLQSANEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLCSKELGSARVRCSKLHLVDLAGSERVGKTGVGGQILTEAKYINLSLHYLEQVIIALSEKDRSHIPYRNSMMTSVLRDSLGGNCMTTMIATVSVEKKNIGESLLKARVREKPCAGSSIPLTGMLDGADRRSHEDVQKLEEMLAHRDNEISILVNMLKREKKKLQDVTSQMTKPQNKNESPTTLEAAESAKYDSSNGDIHAQRSMTGKRVLELSAGQQEVFEVFLRDHKEHLSIEDKRAVLQQRFVEAKALGEQVNQIRTRVNYLKGELKNRRKQMAVQGLTGNQTESELDPFEEKILTQIEEEKKNYKITSGCLKDLKTEIEHLQLLLEKSKVKIQRDFENWWTQEGARLQGHSGENTGNNRRGISPLSHMLTRKNNLKDDDSDLHEGRQGEIRDKRSLPSCDFSSTPFSLTGDKKTDADIEAFIRARHNLLNSTGETKH
Protein: GTP:AMP phosphotransferase, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Q9VGU6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03169}.
Interaction partners:
- Adenylosuccinate lyase
- Adenosine kinase
- Adenosine kinase
- Adenosine kinase
- Adenine phosphoribosyltransferase
- Nucleoside diphosphate kinase
- Ribonucleoside-diphosphate reductase large subunit
- Nucleoside diphosphate kinase
- FI21821p1
- Nucleoside diphosphate kinase-like domain-containing protein
Sequence:
MFTKIFRAVIIGAPGSGKGTISELICKNHGCVHISTGDILRQNIIKNTELGKKAKQYIAEGKLVPDAIVTKTMLARITEVGNRSYILDGFPRNIAQAEALAAREQIDAVITLDVPHSVIIDRVKNRWIHAPSGRVYNIGFKNPKVPGKDDVTGEPLMQREDDKPHVVAKRLELYDEVMSPVIAWYEKKGLVATFKGKQTKEIWPMMELFLNDRINA
Protein: Agamous-like MADS-box protein AGL27 (MADS box FLC1-like nuclear protein) (Protein FLOWERING LOCUS M) (Protein MADS AFFECTING FLOWERING 1) (Q9AT76)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in the negative regulation of flowering time in both long and short days, probably through the photoperiodic and vernalization pathways. Prevents premature flowering.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Inactive protein FRIGIDA
- Protein TWIN SISTER of FT
- Protein LEAFY
- FAD/NAD
- ENHANCER OF AG-4 protein 2
- MADS-box protein
Sequence:
MGRRKIEIKRIENKSSRQVTFSKRRNGLIDKARQLSILCESSVAVVVVSASGKLYDSSSGDDISKIIDRYEIQHADELRALDLEEKIQNYLPHKELLETVQSKLEEPNVDNVSVDSLISLEEQLETALSVSRARKAELMMEYIESLKEKEKLLREENQVLASQMGKNTLLATDDERGMFPGSSSGNKIPETLPLLN
Protein: Olfactory receptor (Q0VEP0)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MEKAVLINQTSVMSFRLTGLSTNPKVQMAIFFIFLIFYVLTLVGNILIVITIIHDHRLHTPMYFFLSNLSFIDVCHSTVTVPKMLSDTFSEEKLISFDDCVVQIFFLHLFACTEIFLLTVMAYDRYVAICKPLRYMTIMNWKVCMVLGGAMWTAGTIHSISFTSLTIKLPYCGPNELDSFFCDVPQVIELACTDTRITEILVVSNSGMISMVCFVIIVVSYAVILVSLRQQISDGKRKALSTCAAHLTVVTLFLGHCIFIYSRPAISLPEDKIVSAFFTAITPLLNPIIYTFRNEDMKSALKKLIRRKEGKEK
Protein: Auxin-responsive protein IAA31 (Indoleacetic acid-induced protein 31) (Q8H174)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Auxin response factor 5
- Auxin response factor 7
- Auxin response factor 16
- Auxin-responsive protein IAA33
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin-responsive protein IAA27
- Auxin transporter protein 1
- Auxin-responsive protein IAA5
- Auxin-responsive protein IAA3
- Auxin response factor 1
Sequence:
MEVSNSCSSFSSSSVDSTKPSPSESSVNLSLSLTFPSTSPQREARQDWPPIKSRLRDTLKGRRLLRRGDDTSLFVKVYMEGVPIGRKLDLCVFSGYESLLENLSHMFDTSIICGNRDRKHHVLTYEDKDGDWMMVGDIPWDMFLETVRRLKITRPERY
Protein: HNH domain-containing protein (Q8NSB1)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- DUF222 domain-containing protein
- DUF222 domain-containing protein
- DUF222 domain-containing protein
- ABC-type transporter, permease components
- HNH nuclease domain-containing protein
- LTD domain-containing protein
Sequence:
MFYFTVNNPQDPLSTEIVETNRRDLAFWHRLRPKDDDDLATAINKICVRTGLSRKLIAACLFSICFLPYLPNFHKLVEKLGHLDMARINAITKAGEKVPSEKRELFDAYLVDYLTPRAEAQCLPQASSISAMMRKFIAQHCPDDKASSATNDGSIRYRRNNKGGISITVDATASEVTEIKAALEQMSKDKDCTPGTSLLHIIRGLPTKVVLNTYGTKDSPEYLEGGTWLSKEQSEFWKTRTTSSRDMDAAHFSYTTAYAPTREMRVYIKGLRTTCSVPGCSVAVENCQLDHIIPWGEGGPTTPWNIHPLCVFHHIQKTEGRLQCYPLPDGTVLFLVDGIPVFSIPDGPLSKSNKTWGTKFGKYMERRIAA
Protein: Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (P43432)
Organism: Mus musculus (Mouse)
Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Subcellular location: Secreted {ECO:0000269|PubMed:34374750}.
Interaction partners:
- Interleukin-12 subunit alpha
- Interleukin-12 receptor subunit beta-1
- Interleukin-23 subunit alpha
- Interleukin-23 receptor
- Interleukin-12 receptor subunit beta-2
- Interferon gamma
- Interleukin-2 receptor subunit alpha
- Tumor necrosis factor
- Interferon gamma receptor 1
- Interleukin-6
Sequence:
MCPQKLTISWFAIVLLVSPLMAMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRS
Protein: Vacuolar protein sorting-associated protein 62 (P53285)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in vacuolar protein sorting.
Subcellular location: Membrane; Single-pass membrane protein.
Interaction partners:
- Uncharacterized protein YGR045C
- Putative uncharacterized protein YDR250C
Sequence:
MRISKNSHKRQRTRLYFLVTFIIYSIIPCRAVLVPWLDDDPFEATLLEMGDEPWSKDILSSTPPLHPSEVTEDNKSLKQRGNVPQYVIDNSPLLHLYSEEKYWPADVKDFVKRFQLRDHSGEKIINEHLRDLSDLQEYYSVELENGTWGRVSSEGTYMTSLDDFDKGPDWLLGEQPEYGTGHIKKAPAVLFVVDKGNGWVDAFWFYFYPFNWGPYIMGSGPWGNHVGDWEHSLVRFYKGEPQYLWMSAHGGGSAYKFEAIEKIKRLRRVDGKLTNEVIKKPLIFSARGTHAHYASVGQHAHDVPFFFMPLSDFTDRGPLWDPSLNYYAYTVTVGEKMTPCGAEETKMGLEWLSFKGAWGDKQLRPRDPRQKWCPFQWKYIDGPKGPLFKNMERVSLCQRFKWWNFWKGCPARRYIKRGEGLDAEKNDLVGDNCGILLYNIRPKWLRSILRFLTWRGSVCFIMDYFTG