wanglab/gogpt-training-data huggingface dataset:
Protein: Enterobactin synthase component F (EC 6.3.2.14) (Enterochelin synthase F) (Nonribosomal peptide synthetase EntF) [Includes: L-serine--[L-seryl-carrier protein] ligase (EC 6.2.1.72) (Serine-activating enzyme) (Seryl-AMP ligase)] (P11454)
Organism: Escherichia coli (strain K12)
Function: Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. EntF catalyzes the activation of L-serine via ATP-dependent PPi exchange reaction to form seryladenylate. Activated L-serine is loaded onto the peptidyl carrier domain via a thioester linkage to the phosphopanthetheine moiety, forming seryl-S-Ppant-EntF. EntF acts then as the sole catalyst for the formation of the three amide and three ester linkages found in enterobactin, using seryladenylate and 2,3-dihydroxybenzoate-S-Ppant-EntB (DHB-S-Ppant-EntB) as substrates, via the formation of a DHB-Ser-S-Ppant-EntF intermediate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10692387}. Note=Membrane-associated. {ECO:0000269|PubMed:10692387}.
Interaction partners:
- Enterobactin biosynthesis protein YbdZ
- Enterobactin synthase component E
- Enterobactin synthase component D
- 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
- Enterobactin synthase component B
- Iron
- Isochorismate synthase EntC
- Ferrienterobactin receptor
- Ferric enterobactin-binding periplasmic protein FepB
- Acyl carrier protein
Sequence:
MSQHLPLVAAQPGIWMAEKLSELPSAWSVAHYVELTGEVDSPLLARAVVAGLAQADTLRMRFTEDNGEVWQWVDDALTFELPEIIDLRTNIDPHGTAQALMQADLQQDLRVDSGKPLVFHQLIQVADNRWYWYQRYHHLLVDGFSFPAITRQIANIYCTWLRGEPTPASPFTPFADVVEEYQQYRESEAWQRDAAFWAEQRRQLPPPASLSPAPLPGRSASADILRLKLEFTDGEFRQLATQLSGVQRTDLALALAALWLGRLCNRMDYAAGFIFMRRLGSAALTATGPVLNVLPLGIHIAAQETLPELATRLAAQLKKMRRHQRYDAEQIVRDSGRAAGDEPLFGPVLNIKVFDYQLDIPDVQAQTHTLATGPVNDLELALFPDVHGDLSIEILANKQRYDEPTLIQHAERLKMLIAQFAADPALLCGDVDIMLPGEYAQLAQLNATQVEIPETTLSALVAEQAAKTPDAPALADARYLFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYPDDRLKMMLEDARPSLLITTDDQLPRFSDVPNLTSLCYNAPLTPQGSAPLQLSQPHHTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHYPLTGEDVVAQKTPCSFDVSVWEFFWPFIAGAKLVMAEPEAHRDPLAMQQFFAEYGVTTTHFVPSMLAAFVASLTPQTARQSCATLKQVFCSGEALPADLCREWQQLTGAPLHNLYGPTEAAVDVSWYPAFGEELAQVRGSSVPIGYPVWNTGLRILDAMMHPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFAPGERMYRTGDVARWLDNGAVEYLGRSDDQLKIRGQRIELGEIDRVMQALPDVEQAVTHACVINQAAATGGDARQLVGYLVSQSGLPLDTSALQAQLRETLPPHMVPVVLLQLPQLPLSANGKLDRKALPLPELKAQAPGRAPKAGSETIIAAAFSSLLGCDVQDADADFFALGGHSLLAMKLAAQLSRQVARQVTPGQVMVASTVAKLATIIDAEEDSTRRMGFETILPLREGNGPTLFCFHPASGFAWQFSVLSRYLDPQWSIIGIQSPRPNGPMQTAANLDEVCEAHLATLLEQQPHGPYYLLGYSLGGTLAQGIAARLRARGEQVAFLGLLDTWPPETQNWQEKEANGLDPEVLAEINREREAFLAAQQGSTSTELFTTIEGNYADAVRLLTTAHSVPFDGKATLFVAERTLQEGMSPERAWSPWIAELDIYRQDCAHVDIISPGTFEKIGPIIRATLNR
Protein: Syntaphilin (B5DF41)
Organism: Rattus norvegicus (Rat)
Function: Inhibits SNARE complex formation by absorbing free syntaxin-1.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Synapse, synaptosome.
Interaction partners:
- Trafficking kinesin protein 1
- Trafficking kinesin-binding protein 2
- Ras homolog gene family member T1
Sequence:
MAMSLQGSRRASAGSRRRTSPPVSVRDAYGTASLSSSSNSGSCKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIRQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGVAKEEGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQAGDPSNTPAEDRADSGFVAADDTLSRTEALEASSLLSSGVDCGFEEASLHSSFNLGPRFPASNTYEKLLCGMEAAVQASCMQERAIQTDFVQYQPDLNTILEKVGQAQGCSSVLKDRHSELDLHPSGPRDPDSAVVVTVGDEPEAPEPITRGPAIHRPAVNSNPGLPVSVVCPVEEEEEAAAAAAAAAAATTTTTTTEKEPKSYWSRHYIVDLLAVVVPAVPTVAWLCRSQRRQGQPIYNISSLLRGCCTVALHSIRRISCSLSQPSAGSSGGSQL
Protein: 4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic (HTPA synthase 1) (EC 4.3.3.7) (Q9LZX6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Subcellular location: Plastid, chloroplast.
Interaction partners:
- 4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic
- 4-hydroxy-tetrahydrodipicolinate reductase 1, chloroplastic
- aspartate-semialdehyde dehydrogenase
- Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic
- Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic
- 4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic
- Diaminopimelate decarboxylase 1, chloroplastic
- Diaminopimelate decarboxylase 2, chloroplastic
- Homoserine dehydrogenase
- Aspartokinase 1, chloroplastic
Sequence:
MSALKNYGLISIDSALHFPRSNQLQSYKRRNAKWVSPIAAVVPNFHLPMRSLEDKNRTNTDDIRSLRVITAIKTPYLPDGRFDLQAYDDLVNTQIENGAEGVIVGGTTGEGQLMSWDEHIMLIGHTVNCFGGRIKVIGNTGSNSTREAIHATEQGFAMGMHGALHINPYYGKTSIEGMNAHFQTVLHMGPTIIYNVPGRTCQDIPPQVIFKLSQNPNMAGVKECVGNNRVEEYTEKGIVVWSGNDDQCHDSRWDHGATGVISVTSNLVPGLMRKLMFEGRNSALNAKLLPLMDWLFQEPNPIGVNTALAQLGVARPVFRLPYVPLPLSKRIEFVKLVKEIGREHFVGDRDVQVLDDDDFILIGRY
Protein: Carnosine dipeptidase 2, isoform C (EC 3.4.13.-) (A0A0B4LEQ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVEWTADRLRSLGAETELADVGQQTLPNGQIIPLPKVLLGTLGKDPSKKTVLVYGHLDVQPALKEDGWNTNPFELTEVDGKLFGRGASDDKGPVLCWIHAIEAYQKLNIALPVNVKFVFEGMEESGSEGLDDLLLERKDNFLADVDFVCISDNYWLGKKRPCLTYGLRGLAYFQVEVECSSKDLHSGVFGGTVHEAMPDLCHLLSILVDKDTNILVPGVDRDVAPQIKNEQSIYENIDFEVSEYKKDIGVEQLPHNGDKTRLLQARWRYPSLSVHGIEGAFYEPGAKTVIPKKVIGKFSIRLVPNQDPKHIEECVVKYLNDKWAERGSPNKMKVTMLSAGKPWTEDPNHPHYEAAKRAIKHVFNVEPDMTREGGSIPVTLTLQEATGKNVILVPVGACDDGAHSQNEKIDIYNYIEGTKLLGAYLHEVGKL
Protein: Transcription factor zip-10 (Q22835)
Organism: Caenorhabditis elegans
Function: Transcription factor that regulates the expression of genes in response to changes in temperature. In particular, binds to the promoter region of genes such as asp-17 in response to severe cold to warm temperature transitions to promote gene expression. Promotes stress-induced death, particularly in older animals, following cold shock followed by warming and this may have evolved as a form of kin survival under thermal stress conditions, favoring the survival of younger animals.
Subcellular location: Nucleus {ECO:0000305|PubMed:29664006}.
Interaction partners:
- Protein isy-1
- BZIP domain-containing protein
Sequence:
MTTMTNSLISNSVSSVPESLFSSASIHRPVAINPAMLAQFSINLPVLPFESSASLGTSTTSSSRCSSTESSAAPGKIRRGRPQQEIADGQDAHSQKKRHRRLYARQYRAQMRQKVENVKSLHDEKEQLELEVKALRQAVSGLQQENAQKDFLISILQLNNQINHS
Protein: Cytochrome P450 84A1 (EC 1.14.-.-) (Ferulate-5-hydroxylase) (F5H) (Q42600)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cinnamoyl-CoA reductase 2
- Cinnamoyl-CoA reductase 1
- Flavone 3'-O-methyltransferase 1
- 4-coumarate--CoA ligase 4
- 4-coumarate--CoA ligase 1
- 4-coumarate--CoA ligase-like 7
- 4-coumarate--CoA ligase-like 6
- 4-coumarate--CoA ligase 2
- F5F19.5 protein
- 4-coumarate--CoA ligase 3
Sequence:
MESSISQTLSKLSDPTTSLVIVVSLFIFISFITRRRRPPYPPGPRGWPIIGNMLMMDQLTHRGLANLAKKYGGLCHLRMGFLHMYAVSSPEVARQVLQVQDSVFSNRPATIAISYLTYDRADMAFAHYGPFWRQMRKVCVMKVFSRKRAESWASVRDEVDKMVRSVSCNVGKPINVGEQIFALTRNITYRAAFGSACEKGQDEFIRILQEFSKLFGAFNVADFIPYFGWIDPQGINKRLVKARNDLDGFIDDIIDEHMKKKENQNAVDDGDVVDTDMVDDLLAFYSEEAKLVSETADLQNSIKLTRDNIKAIIMDVMFGGTETVASAIEWALTELLRSPEDLKRVQQELAEVVGLDRRVEESDIEKLTYLKCTLKETLRMHPPIPLLLHETAEDTSIDGFFIPKKSRVMINAFAIGRDPTSWTDPDTFRPSRFLEPGVPDFKGSNFEFIPFGSGRRSCPGMQLGLYALDLAVAHILHCFTWKLPDGMKPSELDMNDVFGLTAPKATRLFAVPTTRLICAL
Protein: Keratin-associated protein 19-6 (Q3LI70)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
Sequence:
MRYYGSYYRGLGYGCGGFGGLGYGCGCGGYRYGSGYGGYRYGCCRPSCREGYGFSGFY
Protein: Myosin regulatory light chain (Non-muscle myosin regulatory light chain) (nmRLC) (Q09510)
Organism: Caenorhabditis elegans
Function: Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19675126}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19675126}. Note=Forms a filamentous structure which may co-localize with actin. {ECO:0000269|PubMed:19675126}.
Interaction partners:
- EF-hand domain-containing protein
- Actin
- Myosin-11
- Myosin-11
- Myosin-2 essential light chain
- EF-hand domain-containing protein
- Myosin, essential light chain
- Ras-like GTP-binding protein rhoA
- Troponin T
- Abnormal cell migration protein 10
Sequence:
MASRKTVNRRQRPQRATSNVFAMFDQAQIQEFKEAFNMIDQNRDGFIDQEDLKDMFASLGKEVTEQFIDSMINEAPGAQPINFTMFLTLFGEKLTGTDPEEVIRNAFQCFDEDNSGKLNEEHLRELLTTMGERYSEEQVDELFRDAPIKGGQFDYVEFTRMLKHGTKDKDEA
Protein: Frizzled-6 (Fz-6) (hFz6) (O60353)
Organism: Homo sapiens (Human)
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:Q61089}. Apical cell membrane; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with FZD3 at the apical face of cells (By similarity). Localizes to the endoplasmic reticulum membrane in the presence of LMBR1L (By similarity). {ECO:0000250|UniProtKB:Q61089}.
Interaction partners:
- Protein Wnt-11
- Protein Wnt-5a
- Protein Wnt-4
- Cadherin EGF LAG seven-pass G-type receptor 1
- Proto-oncogene Wnt-1
- Vang-like protein 2
- Protein Wnt-5b
- Protein Wnt-7a
- Segment polarity protein dishevelled homolog DVL-1
- Tyrosine-protein kinase RYK
Sequence:
MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREVKADGASTPRLREQDCGEPASPAASISRLSGEQVDGKGQAGSVSESARSEGRISPKSDITDTGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT
Protein: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] (P07953)
Organism: Rattus norvegicus (Rat)
Function: Synthesis and degradation of fructose 2,6-bisphosphate.
Interaction partners:
- Fructose-1,6-bisphosphatase isozyme 2
- Fructose-1,6-bisphosphatase 1
- ATP-dependent 6-phosphofructokinase, liver type
- RCG30218, isoform CRA_b
- Hexokinase-2
- ATP-dependent 6-phosphofructokinase, muscle type
- ATP-dependent 6-phosphofructokinase, platelet type
- Hexokinase-3
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
Sequence:
MSREMGELTQTRLQKIWIPHSSSSSVLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYRNYEFFRPDNTEAQLIRKQCALAALKDVHKYLSREEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPEIIAENIKQVKLGSPDYIDCDQEKVLEDFLKRIECYEINYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHVQSRTAYYLMNIHVTPRSIYLCRHGESELNLRGRIGGDSGLSARGKQYAYALANFIRSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCRVESIYLNVEAVNTHRDKPENVDITREAEEALDTVPAHY
Protein: vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.17.4.4) (A0A3B3ISV4)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
Sequence:
MGRGGGGGGGGGGGGGGGGGGGGWVGPRRAAAAEVEAEGGGGGGGGKMAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALILMTSSIMSVVGSLYLAYILYFVLKEFCIICIVTYVLNFLLLIINYKRLVYLNEAWKRQLQPKQD
Protein: V-set and transmembrane domain-containing protein 1 (Signal inhibitory receptor on leukocytes-1) (SIRL-1) (Q6UX27)
Organism: Homo sapiens (Human)
Function: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).
Subcellular location: [Isoform 1]: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:22960280}.
Interaction partners:
Sequence:
MTAEFLSLLCLGLCLGYEDEKKNEKPPKPSLHAWPSSVVEAESNVTLKCQAHSQNVTFVLRKVNDSGYKQEQSSAENEAEFPFTDLKPKDAGRYFCAYKTTASHEWSESSEHLQLVVTDKHDELEAPSMKTDTRTIFVAIFSCISILLLFLSVFIIYRCSQHSSSSEESTKRTSHSKLPEQEAAEADLSNMERVSLSTADPQGVTYAELSTSALSEAASDTTQEPPGSHEYAALKV
Protein: Anon1A4 (Decondensation factor 31, isoform A) (Decondensation factor 31, isoform B) (Decondensation factor 31, isoform F) (LD21289p) (O16043)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Histone H2A.v
Sequence:
MADVAEQKNETPVVEKVAAEEVDAVKKDAVAAEEVAAEKASITENGGAEEESVAKENGAADSSATEPTDAVDGEKASEPTVSFAADKDEKKDEDKKEDSAADGEDTKKESSEAVLPAVENGSEEVTNGDSTDAPAIEAVKRKVDEAAAKADEAVATPEKKAKLDEASTKDEVQNGAEASEVAA
Protein: Conserved protein (O05882)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable conserved integral membrane transport protein
- Methanethiol S-methyltransferase
Sequence:
MDVKEVLLPGVGLRYEFTSYRGDRIGIVARRSGGFDVVLYGRDDPDEARPVLRLTDEEAEAVAQILGAPRIAERFTELTREVPGLKAGQIHIRAGSLFVDRPLGDTRARTRTGASIVAIVRDEDVLASPGPTDVLRAGDVLIVIGTEDGIAGVEQIVEKG
Protein: Acyl-CoA N-acyltransferases (NAT) superfamily protein (Q8H0Y9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MATGTATEKPKIVWNEGRHRFETDDHEAFIEYKMKNDGKVMDLVRTFVPPSKAGLGLASHLCVAAFEHASEHSFSIIPTCSYVSETFLHRNPTWQRLVHSEDDSKNLKSSI
Protein: Transcription factor TCP19 (Q9LT89)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor TCP13
- Transcription factor TCP24
- Transcription factor TCP17
- Transcription factor TCP3
- Transcription factor TCP10
- Transcription factor TCP18
- Pyridoxal phosphate
- TraB family protein
- Transcription factor TCP12
- Transcription factor TCP5
Sequence:
MESNHEGNAIQVIDQVTTMTHLSDPNPKTKPGMMLMKQEDGYLQPVKTKPAPKRPTSKDRHTKVEGRGRRIRMPAGCAARVFQLTRELGHKSDGETIRWLLERAEPAIIEATGTGTVPAIAVSVNGTLKIPTSSPVLNDGGRDGDGDLIKKRRKRNCTSDFVDVNDSCHSSVTSGLAPITASNYGVNILNVNTQGFVPFWPMGMGTAFVTGGPDQMGQMWAIPTVATAPFLNVGARPVSSYVSNASDAEAEMETSGGGTTQPLRDFSLEIYDKRELQFLGGSGNSSPSSCHET
Protein: Transmembrane protein 97 (J3KT68)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGW
Protein: Serine/threonine-protein kinase haspin homolog (EC 2.7.11.1) (P83103)
Organism: Drosophila melanogaster (Fruit fly)
Function: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-4' (H3T3ph) during mitosis and interphase. Function is essential for chromosome organization during mitosis and genome organization in interphase cells, thus playing a functional role in gene regulation. During mitosis, may act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity). During interphase, associates with the cohesion complex and mediates pds5 binding to chromatin to ensure correct sister chromatid cohesion, chromatin organization, and also functions with Pds5-cohesin to modify Polycomb-dependent homeotic transformations. Function during interphase is required for insulator activity, nuclear compaction, heterochromatin-induced position-effect variegation and PcG-mediated pairing-sensitive silencing.
Subcellular location: Nucleus lamina {ECO:0000269|PubMed:32750047}. Chromosome {ECO:0000269|PubMed:32750047}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8TF76}.
Interaction partners:
- Acyl carrier protein, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 23 kDa subunit
- NADH dehydrogenase iron-sulfur protein 6
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase iron-sulfur protein 4
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 13 kDa B subunit
Sequence:
MLSISKTKMDFLEEGRWKDPFDELLDSRTKLSKMNIVKQNVRVTYNIDSSVENSSYIEIKEPNHKNEPLTLEDCSIKVYCPSDSISTPCDKRLGGTTGLFETDLSPITRLKLEGVEDSRDKCADTNEADLYVNVEILFQNINSSPKKCSNFGKKRLSNLNKMVTAVHPSISLNPGKWRKSLNNFIRSKITETNFTKKVERRSSICQDRKSLVLKGEHKFENKYEEDVLKYCHQCTPLPFNTAYEQHKLLNTKKIGEGAYGEVFRCSRNQEVLKDHISDIVLKIIPLEGSTVINGEKQKTFSQILPEIIITKKMCSLRTSKTNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNEKGSENDHPELFGDNQLFAVLELKFAGSDMANFKFLNSEQSYYALQQIILALAVGEEEYQFEHRDLHLGNILIEYTNKKHIVCTFKSSNLTLLSKGVNVTIIDYTLSRVTINDCCYFNDLSRDEELFQATGDYQYDVYRMMRNELKNNWSSFSPKTNIIWLSYVIVKVLDSVKYKSINTKVHRMYIDKIKELKNIIMTFESASHCANYLFNLN
Protein: Protein Wnt-10a (Q9GZT5)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium. Required for normal hair follicle function.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Interaction partners:
- Protein-serine O-palmitoleoyltransferase porcupine
- Wnt inhibitory factor 1
- Low-density lipoprotein receptor-related protein 5
- Palmitoleoyl-protein carboxylesterase NOTUM
- Ectodysplasin-A
- Frizzled-1
- Low-density lipoprotein receptor-related protein 6
- Frizzled-7
- Glypican-3
- Frizzled-8
Sequence:
MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
Protein: Proteinase inhibitor PSKP-2 (P83579)
Organism: Phyllomedusa sauvagei (Sauvage's leaf frog)
Function: May have a role in mucosal defense against microbes by interacting directly with their membranes.
Subcellular location: Secreted {ECO:0000269|PubMed:15153102}.
Interaction partners:
Sequence:
VIEPDCKKYEGKKCPPDIALVCGTNGREYYNECALCVFIRDSTLKADKAIKIKKWGKC
Protein: Kinesin motor domain-containing protein (Q8MQ20)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Arf-GAP domain-containing protein
- Disks large homolog 1
- Glutamate receptor 1
- Kinesin heavy chain
Sequence:
MTAPDEESAVKVAIRVRPFNKRELDLKTKSVVRIQKEQCVLHHPIEEKNSKTFTFDHSFCSTDPHSYDFASQETVSYHLGSGVVENAFSGYNACIFAYGQTGSGKSYTMMGTPDQPGIIPRVCNDIFTRIQETSNSSLSFKVEVSYMEIYNERVRDLLDPKKSSKALKVREHKILGPMVDGLSILAVNSFEQISNLLEEGNKSRTVAATNMNAESSRSHAVFSLIVTQTLHDLENGFSGEKVAKISLVDLAGSERAGKTGAVGKRLEEGGNINKSLTTLGMVISALAERNSKKDKFIPYRDSVLTWLLKDSLGGNSRTVMIATLSPAADNYEETLSTLRYADRAKKIVNHAIINEDPNARVIRELREEVETLRMQITQTKKEHAETEELRERLAESERLVAQMNKSWEERLKETDTLNKERQKDLTEIGISIESSGIKVEKDRFYLVNMNADPSLNELLVYYINGSAIIGNSEELETSRDSGLSMTCSDSSRRDDDKERTSIVLRGLGIMRRHAKMTVEEYGGRLRLFVAPMSSECRICVNGKQITERTLLRNGNRLLVGMNHFFKVNCPKVMDMEQSIMEDSTMFDYNDAWHEVNDANPISSAVDQYMESVTLKHQEDKKAALEQQYEAFEKYIQSLTAGGFTPSTPMTPGFCLPTPITTPTGLPPFPFPANPKQSVKSKFFYWAQRKEEMFAESLKRLKADVIHANALVREANMISKELNKKPKRQTTYDVTLQIPASNLRPIKIKAGQFVCEPVIVVRREGMSGSQFWTVSQLESRLVDMRDTYNDMLNGFTRTSESLNGTPHASPMKIAGIPMNECSSLVIDPFFESQEHHNLVGVANVFLEVLFHDLRLDYQVPIISQQGEVAGRLHVQIFRVVTQEEMDETSNNGPETLLGKTITCRVRIKRASGLPEKLSNFVFCQYSFFNISELLVVAPANEAANHSSCPTTVIFEHQRDFNVMVTEEFMEYVRDDALSIEVWGHRICGHPEERILDTDEKSKSLQNRWMEVTRRLETWSEVRELNDNGDWTSVEVRHADDVSTGGIYQLKQGQQRRLVVGVNVAAPDGLPISIDCITSVSIGAIMAVKSTNNLKSIDSYQEEDLDKIRKQWSHALKSRQYYLQHQLDSLSAKSGKSEAELDREHSLMGQWVALTEERTAVECPTPNSCIPGAPCDWIAPEGVERHIPVLFLDLNSDDMTGEMTSDENVPRVAGLHSMLPLEPEGNLLMVPIQKYDDKDHVATCSWDSSVHDCPALNVPTNSNDRVYAIVKIMVRLSHPCPMHIVLRKRICLQIYKKPSLTEKFFKKMLGTETIHRTSLYYDVVAHIPKSSQDMEDRSSLAMMAAKDTSHDEQGGGSSRSSTSSTESQHQQQTLNYIEAYTKSIQAVESMLKLDRLRQEVAITNMLTKKERLQRIQNFGLPMHSLRMNRAVSLPNAISNAGQINGVEKRSDTPMSISSSNSMARPTSLNLKPLCIGKLTSIISPYNDKLTGIMEESNSLRIETVPTRSSTVPETMCFSAAKKLSPTEDVKNGNENSSPTRTATNGTSMGVNLCLPLDNNNQFASKKMQNGDLVDLKIN
Protein: Putative reactive intermediate deaminase TdcF (EC 3.5.4.-) (P0AGL2)
Organism: Escherichia coli (strain K12)
Function: May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2-ketobutyrate.
Interaction partners:
- PFL-like enzyme TdcE
- Propionate kinase
- L-threonine dehydratase catabolic TdcB
- Threonine/serine transporter TdcC
- L-serine dehydratase TdcG
- Thiamine import ATP-binding protein ThiQ
Sequence:
MKKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLNDFATINEVYKQFFDEHQATYPTRSCVQVARLPKDVKLEIEAIAVRSA
Protein: FI08810p (Q9VBY2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- U3 small nucleolar ribonucleoprotein protein IMP3
- U3 small nucleolar ribonucleoprotein protein MPP10
- LD47749p
- Lethal
- LD17611p
- LD10780p
- LD47550p
- LD38375p
- FI04466p
- LD31322p
Sequence:
MLRKQARQRREYLYNKALTERLKSKQKIQETVVKSINENKAIGSKNVKKSLTAYKSLKYADEGVDDRTVNDEYHYAGCEDPKIMLTTSHNPSSRLKMFMKELRLIIPNAQQMNRGNYQLTTLMHACRANNVTDFLIVHEHRGIPDSLVVCHLPYGPTAFFNISDVVMRHDIPDIGHMSEQKPHLIFNNFKTPIGLRTVKILKHLFPVPKENSQRVMSFLNHNDSIIFRHHQYKYVNKELELTEVGPRFSLKLYQIKLGTLENIKAADTEWINRPYMNTSQKRLIFSNDPGIINKDTEA