wanglab/gogpt-training-data huggingface dataset:
Protein: RNA-binding post-transcriptional regulator cip1 (Csx1-interacting protein 1) (O42923)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16407405, ECO:0000269|PubMed:16823372}.
Interaction partners:
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor cwf10
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein E
- U2 snRNP component prp10
- Pre-mRNA-splicing factor sap145
- RNA-binding post-transcriptional regulator cip2
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein Sm D1
Sequence:
MPNEIFPWKIRVDESRGLAGNSGTKKSNHEALSRLQSPLNSPKLQPIGSPQASRKTSGSGSSAPLYPKWSGALSLASSRAASPAPSDSFPTFGYSQLGGLENSSKGSALFNSANSIGTPYLSSRNSNSANEASAMAFHNVSPPSGAESSSESKSFSASGKGNKADTSAEPSLDAFNSTQIKAGSTANSNSTPVEPGEDTIPTAIVVKNIPFSLEKDTLLDHFKQLGIPRPYAFNYHYDNGIFRGLAFANFYRPEEAQVVVQTLNGYEINGRRLRVEWKRQLPAAEREKVEKAKKRQAEERRRKQQYKMFEVSFTDQGLNLNDTGTLETYSRLLLFAHQCIPSREITFETTSKDGNLLNAIRIFCLYFDLDYYARPNGEVLKLVVTHPNKKNTSVSQSQPASPNLRFNMPAPLATRFLQEHSLNGTKSAPITPPPSFAVPLTNQLRSIDDKIYGNESPLQKASTLSSPFNSKNDNDASTSASKQSFGVSHF
Protein: Stress response regulator protein 1 (Q59M56)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for stress adaptation, morphogenesis and virulence.
Interaction partners:
- Transcription factor SKN7
Sequence:
MISMNPIMIRNNLSRSSSPAAPPTTNHSSTVDYFSIKPKLSLDINSQSDSNSTQSNNNEDTHSEQSDYNSYTHNQYYDSDDDEDDFDIRDQLLDPFDKITLSNCNEEYYSPLTPFDGQTTSPQDSIISSKSSNKSTTVVPSPQFQLTLPKLTTYSFLIVDDNIINLKILNRILLKLFPKCHIVQIQDSKLVKDLLHKQSFDSIFIDIEMPDVNGIDIAQFVRQDTKFDNMGMVAVTTRNSTQDLELFKQCGIDFTFHKPLNYSLDFMANSIDDIIITRKNKI
Protein: Acanthoscurrin-1 (Q8I948)
Organism: Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus)
Function: Antimicrobial protein. Strong activity against the Gram-negative bacterium E.coli SBS363 and yeast C.albicans. No detectable activity against the Gram-positive bacterium M.luteus.
Subcellular location: Secreted {ECO:0000269|PubMed:12818635}.
Interaction partners:
Sequence:
MAFRMKLVVCIVLLSTLAVMSSADVYKGGGGGRYGGGRYGGGGGYGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGRGGGYGGGGGYGGGYGGGYGGGKYKG
Protein: Tyrosine-protein phosphatase 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2) (PTPase 2) (P29461)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Major phosphatase responsible with PTP3 for tyrosine dephosphorylation of MAP kinase HOG1 to inactivate its activity. May also be involved in the regulation of MAP kinase FUS3. May be implicated in the ubiquitin-mediated protein degradation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Mitogen-activated protein kinase HOG1
- Tyrosine-protein phosphatase 3
- Mitogen-activated protein kinase SLT2/MPK1
- Mitogen-activated protein kinase KSS1
- Protein phosphatase 2C homolog 1
- Mitogen-activated protein kinase FUS3
- MAP kinase kinase PBS2
- Tyrosine-protein phosphatase YVH1
- Osmosensing histidine protein kinase SLN1
- Signaling mucin HKR1
Sequence:
MDRIAQQYRNGKRDNNGNRMASSAISEKGHIQVNQTRTPGQMPVYRGETINLSNLPQNQIKPCKDLDDVNIRRNNSNRHSKILLLDLCAGPNTNSFLGNTNAKDITVLSLPLPSTLVKRSNYPFENLLKNYLGSDEKYIEFTKIIKDYDIFIFSDSFSRISSCLKTTFCLIEKFKKFICHFFPSPYLKFFLLEGSLNDSKAPSLGKNKKNCILPKLDLNLNVNLTSRSTLNLRINIPPPNDSNKIFLQSLKKDLIHYSPNSLQKFFQFNMPADLAPNDTILPNWLKFCSVKENEKVILKKLFNNFETLENFEMQRLEKCLKFKKKPLHQKQLSQKQRGPQSTDDSKLYSLTSLQRQYKSSLKSNIQKNQKLKLIIPKNNTSSSPSPLSSDDTIMSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPAVSEASTTETKTDKSYPMCPVDAKNHSCKPNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVFQVKKTAPQNDNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLDSCGVDMNDIIKLHKVKNSLLFNPQSFITSLEKDVCKPDLIDDNNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSNKIDVWNMTQDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQIKNALPC
Protein: Intermembrane transport protein YebT (P76272)
Organism: Escherichia coli (strain K12)
Function: Component of a transport pathway that contributes to membrane integrity. May directly span the intermembrane space, facilitating the transport of substrates across the periplasm (Probable).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:27795327}; Single-pass membrane protein {ECO:0000255}; Periplasmic side {ECO:0000269|PubMed:27795327}.
Interaction partners:
- Lipophilic envelope-spanning tunnel protein A
- Intermembrane transport protein PqiA
- Intermembrane phospholipid transport system binding protein MlaD
- Ribosomal RNA small subunit methyltransferase F
- Intermembrane transport lipoprotein PqiC
Sequence:
MSQETPASTTEAQIKNKRRISPFWLLPFIALMIASWLIWDSYQDRGNTVTIDFMSADGIVPGRTPVRYQGVEVGTVQDISLSDDLRKIEVKVSIKSDMKDALREETQFWLVTPKASLAGVSGLDALVGGNYIGMMPGKGKEQDHFVALDTQPKYRLDNGDLMIHLQAPDLGSLNSGSLVYFRKIPVGKVYDYAINPNKQGVVIDVLIERRFTDLVKKGSRFWNVSGVDANVSISGAKVKLESLAALVNGAIAFDSPEESKPAEAEDTFGLYEDLAHSQRGVIIKLELPSGAGLTADSTPLMYQGLEVGQLTKLDLNPGGKVTGEMTVDPSVVTLLRENTRIELRNPKLSLSDANLSALLTGKTFELVPGDGEPRKEFVVVPGEKALLHEPDVLTLTLTAPESYGIDAGQPLILHGVQVGQVIDRKLTSKGVTFTVAIEPQHRELVKGDSKFVVNSRVDVKVGLDGVEFLGASASEWINGGIRILPGDKGEMKASYPLYANLEKALENSLSDLPTTTVSLSAETLPDVQAGSVVLYRKFEVGEVITVRPRANAFDIDLHIKPEYRNLLTSNSVFWAEGGAKVQLNGSGLTVQASPLSRALKGAISFDNLSGASASQRKGDKRILYASETAARAVGGQITLHAFDAGKLAVGMPIRYLGIDIGQIQTLDLITARNEVQAKAVLYPEYVQTFARGGTRFSVVTPQISAAGVEHLDTILQPYINVEPGRGNPRRDFELQEATITDSRYLDGLSIIVEAPEAGSLGIGTPVLFRGLEVGTVTGMTLGTLSDRVMIAMRISKRYQHLVRNNSVFWLASGYSLDFGLTGGVVKTGTFNQFIRGGIAFATPPGTPLAPKAQEGKHFLLQESEPKEWREWGTALPK
Protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE) (Q3UHD9)
Organism: Mus musculus (Mouse)
Function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
- Metabotropic glutamate receptor 1
- Neurabin-2
- Disks large-associated protein 1
- Glutamate receptor 2
- Ras/Rap GTPase-activating protein SynGAP
- SH3 and multiple ankyrin repeat domains protein 3
Sequence:
MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAPGARGSEPRDPGSPRGSEEPGKKRHERLFHRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKVAPPPPAPKPFKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSTAGTGASAAAAGGGGSAAVTTSGGVGAGAGTRGKLSPRKGKSKTLDNSDLHPGPSAGSPPLTVPAIPVPATSVTATSTQPLGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGPGPLPGPQGLSSSSGSRELLGAELRTSPKAVVNSQEWTLSRSIPELRLGVLGDVRSGKSSLIHRFLTGSYQVLEKIESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDESSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCTDMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDAEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGPEASTPMPSPSPSPSSLQLPTDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLSTPSKTEGSAVQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSTCVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPTRDSSREERESWIRAKYEQLLFLAPLGTTEEPLGRQLWAAVEAQDVAAVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSTATTPSAATTPSITATPSPRRRSSAASLGRVDTTIALV
Protein: Titin (D4A8Y1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Uncharacterized protein.
- Cysteine and glycine-rich protein 3
- E3 ubiquitin-protein ligase TRIM63
- Ankyrin repeat domain-containing protein 1
- Nebulin
- Calpain-3
- Next to BRCA1 gene 1 protein
- Ankyrin 1
- F-actin cross-linking protein
- Ankyrin repeat domain-containing protein 2
Sequence:
MTTQAPTFTQPLQSVVVLEGSAATFEAHISGSPVPEVSWFRDGQVISTSTLPGVQISFSDGRARLMIPAVTKANSGRYSLRATNGSGQATSTAELLVTAETAPPNFSQRLQSMTVRQGSQARLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTADLLVQGEEVVPAKKTKTIVSTAQISETRQTRTEKKIEAHFDARSIATVEMVIDGATGQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAGRISTSPIRSVKSPLLIRKTQTTTVATGPEVPPPWKQEGYVASSTEAEMRETTMTSSTQIRREERWEGRYGVQEQVTISGAAGTAASVSARSSFTAEAVTTGAKEVKQETDKSAAVATVVAAVDMARVREPVISAVEQTAQRTTTTAVHVQPAQKQMRKEAEKTAVTKVVVAADKAKEQELRLRTREEIITKQEQTHIAHEQIRKETEKAFVPKVVISATKAKEQETRITGEITTKQEQKRITQETLRQETETIAASVVVATAKSTKLEAAVGIQEETAIQQDQTHLTHGQVMTSWWCEVSCLMSPAAIHIITALQRHFSPQSHGPSPPIWLSLSFLTFAFSLELL
Protein: Coiled-coil domain-containing protein 136 (Nasopharyngeal carcinoma-associated gene 6 protein) (Q96JN2)
Organism: Homo sapiens (Human)
Function: May play a role in acrosome formation in spermatogenesis and in fertilization.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q3TVA9}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q3TVA9}. Note=Exclusively localized on a peripheral part of acrosome membrane (Golgi phase), localized on the equatorial segment of the acrosome (maturation phase). {ECO:0000250|UniProtKB:Q3TVA9}.
Interaction partners:
- Multiple epidermal growth factor-like domains protein 10
Sequence:
MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVVISALLWCWWAETSS
Protein: Ent-kaurene oxidase 2 (OsKO2) (EC 1.14.14.86) (Cytochrome P450 701A6) (Ent-kaurene oxidase-like 2) (OsKOL2) (OsKOS3) (Protein DWARF 35) (Q5Z5R4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Catalyzes three successive oxidations of the 4-methyl group of ent-kaurene giving kaurenoic acid, a key step in gibberellins (GAs) biosynthesis. GAs, which are involved many processes, including stem elongation, play a central role in plant development.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ent-kaurenoic acid oxidase
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Ent-sandaracopimaradiene 3-hydroxylase
- Nitrate reductase
- Nitrate reductase 1
- Nitrate reductase
- 4-coumarate--CoA ligase
Sequence:
MEAFVPGGAGAAAAAVGGFVAAAALAERAGVIAPRKRPNAPPAVPGLPIIGNLHQLKEKKPHQTFAKWAEIYGPIYTIRTGASSVVVLNSTEVAKEAMVAKFSSISTRKLSKALTVLTRDKSMVATSDYCDFHKMVKRYVMSSMLGTSAQKQFRDIRDMMIHNMLSTFHKLVKDDPHAPLIFRDVFKDELFRLSMIQSLGEDVSSVYVDEFGRDISKEEIYNATVTDMMMCAIEVDWRDFFPYLSWVPNKSFETRVFTTETRRTAVMRALIKQQKERIVRGEAKTCYLDFLLAENTLTDEQLMMLVWEALIEAADTTLVTTEWAMYELAKNPDKQERLYQEIREVCGDETVTEEHLPRLPYLNAVFHETLRRHSPVPLIPPRFVHEDTKLAGYDVPAGTEMVINLYGCNMNRKEWESPEEWVPERFAGGRLEVADMYKTMAFGAGRRACAGSLQATHIACAAVARFVQEFGWRLREGDEEKVDTVQLTAYKLHPLHVHLTRRGRM
Protein: Histone H3.3 (P84244)
Organism: Mus musculus (Mouse)
Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Chromobox protein homolog 5
- Histone H4
- DNA
- V
- DNA
- Chromobox protein homolog 3
- Histone H3.1
- WD repeat-containing protein 5
- Bromodomain-containing protein 4
- Histone H3.2
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein: NAD(+) hydrolase TirS (EC 3.2.2.6) (NADP(+) hydrolase TirS) (EC 3.2.2.-) (TIR domain-containing protein in S.aureus) (P0DTS9)
Organism: Staphylococcus aureus (strain MSSA476)
Function: Virulence factor that suppresses host Toll-like receptor 2 (TLR2)-mediated NF-kappa-B signaling upon infection. NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Able to reduce NAD(+) levels in host cells.
Subcellular location: Secreted {ECO:0000305|PubMed:24481289}.
Interaction partners:
Sequence:
MSVLETKLKSQMSKSAKIARNMNKLPDEIDRLRKRIERINKKRKPTSSNIRDLEKSNKQLVTKQQKLADLQVEYTKIEKKINETKINLQKEQSRNQKKLSSMLDKNTKGNEEIMEKLLTNSDQINEISNQIKKAVNQKEIIEYDVFLSHSSLDKEDYVSKISEKLIEKGLKVFEDVKVFEIGKSQTETMNMGILNSRFVVVFLSPNFIESGWSRYEFLSFLNREINEEHVIILPIWHKVSVEDVRAYNPYLVDKYALNTSDFSIEEIVEKIYQVIVNSKN
Protein: Glycine receptor alpha 2 subunit (Glycine receptor subunit alpha-2 precursor) (D1KZ66)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MTRPSVKLLTTLLACLMEMLNFRVSSGKDPDLLSSSSSMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQKWNDPRLAYSEYPDSSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRIFKDGTVLYSIRLTLILSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLDKGPVQVADGLTLPQFLIRDEKDLGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAGVNFVSRQQKEFLRLKRRQRRTQKEEDLQDGRLHFSSYNTTTCVKDGAVVKNTQVNQIQQPSILKNTETNRKKFVDRAKRIDTISRAAFPLAFLIFNVFYWITYKIIRHESARKD
Protein: Transmembrane protein 201 (Spindle-associated membrane protein 1) (Q5SNT2)
Organism: Homo sapiens (Human)
Function: Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery.
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:35311970}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus inner membrane {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}; Multi-pass membrane protein {ECO:0000269|PubMed:19494128}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19494128}. Note=The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane in distinct micro-domains and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle. {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}.
Interaction partners:
- SUN domain-containing protein 1
- Emerin
- SUN domain-containing protein 2
- Lamin-B1
Sequence:
MEGVSALLARCPTAGLAGGLGVTACAAAGVLLYRIARRMKPTHTMVNCWFCNQDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYLEHLNHVVSSAPSLRDPSQPQQWVSSQVLLCKRCNHHQTTKIKQLAAFAPREEGRYDEEVEVYRHHLEQMYKLCRPCQAAVEYYIKHQNRQLRALLLSHQFKRREADQTHAQNFSSAVKSPVQVILLRALAFLACAFLLTTALYGASGHFAPGTTVPLALPPGGNGSATPDNGTTPGAEGWRQLLGLLPEHMAEKLCEAWAFGQSHQTGVVALGLLTCLLAMLLAGRIRLRRIDAFCTCLWALLLGLHLAEQHLQAASPSWLDTLKFSTTSLCCLVGFTAAVATRKATGPRRFRPRRFFPGDSAGLFPTSPSLAIPHPSVGGSPASLFIPSPPSFLPLANQQLFRSPRRTSPSSLPGRLSRALSLGTIPSLTRADSGYLFSGSRPPSQVSRSGEFPVSDYFSLLSGSCPSSPLPSPAPSVAGSVASSSGSLRHRRPLISPARLNLKGQKLLLFPSPPGEAPTTPSSSDEHSPHNGSLFTMEPPHVPRKPPLQDVKHALDLRSKLERGSACSNRSIKKEDDSSQSSTCVVDTTTRGCSEEAATWRGRFGPSLVRGLLAVSLAANALFTSVFLYQSLR
Protein: CD166 antigen (Activated leukocyte cell adhesion molecule) (BEN glycoprotein) (Protein DM-GRASP) (Protein JC7) (SC1 glycoprotein) (CD antigen CD166) (P42292)
Organism: Gallus gallus (Chicken)
Function: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1608932, ECO:0000269|PubMed:1873027, ECO:0000269|PubMed:1931049, ECO:0000269|PubMed:22421359}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q61490}. Cell projection, axon {ECO:0000269|PubMed:1873027, ECO:0000269|PubMed:22421359}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61490}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse. {ECO:0000250|UniProtKB:Q13740}.
Interaction partners:
- General receptor for phosphoinositides 1 associated scaffold protein.
Sequence:
MMEPPAAAARASCRRRPLLCLLLAALCMPPALGLYTVNAVYGDTITMPCRLEVPDGLMFGKWKYEMPNGSPVFIAFRSSTKKNVQYDDVPDYKDRLSLSENYTLSIKNARISDEKRFVCMLVTEDDVSEEPTVVKVFKQPSQPEILHQADFLETEKLKMLGECVVRDSYPEGNVTWYKNGRVLQPVEEVVVINLRKVENRSTGLFTMTSSLQYMPTKEDANAKFTCIVTYHGPSGQKTIQSEPVVFDVHYPTEKVTIRVLSQSSTIKEGDNVTLKCSGNGNPPPQEFLFYIPGETEGIRSSDTYVMTDVRRNATGEYKCSLIDKSMMDATTITVHYLDLQLTPSGEVTKQIGEALPVSCTISSSRNATVFWIKDNTRMKTSPSFSSLQYQDAGNYICETTLQEVEGLKKRKTLKLIVEGKPQIKMTKKTNTNKMSKTIVCHVEGFPKPAVQWTVTGSGSLINKTEETKYVNGKFSSKIIIAPEENVTLTCIAENELERTVTSLNVSAISIPEYDEPEDRNDDNSEKVNDQAKLIVGIVVGLLLVALVAGVVYWLYVKKSKTASKHVDKDLGNIEENKKLEENNHKSET
Protein: HBS1-like protein (EC 3.6.5.-) (ERFS) (Q9Y450)
Organism: Homo sapiens (Human)
Function: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:21448132}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:28204585}.
Interaction partners:
- Protein pelota homolog
- Exosome complex component RRP43
- Exosome complex component CSL4
- Exosome complex component RRP40
- Exosome complex component RRP42
- Exosome complex component RRP45
- Exosome complex component RRP46
- Exosome complex component RRP4
- Exosome complex component RRP41
- DIS3-like exonuclease 1
Sequence:
MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMREVLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKPVDSQTSRSESEIVPKVAKMTVSGKKQTMGFEVPGVSSEENGHSFHTPQKGPPIEDAIASSDVLETASKSANPPHTIQASEEQSSTPAPVKKSGKLRQQIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVGFIPTSGLSGENLITRSQSSELTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCITGKIEAGYIQTGDRLLAMPPNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVGCIFCGPKVPIKACTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKFLTKGQNALVELQTQRPIALELYKDFKELGRFMLRYGGSTIAAGVVTEIKE
Protein: GM03859p (Q8T3N7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEKSEEKTCVVCGTPTRLMCQRCGEPYCNEKCQKLDWQRHRQVCIIMPPLVECRPLQPALNPIQSVENQVALAKTRTKSPIPCVEPTVAVPNKPDLSENWRKHLLPSGMEFFKCRVTFMENDGPIWVVHVANVEAIERMTVNMQRCMQNKKMIRMEGVREDTLVAISVGDKVHRGHVLTVCQKKQEANVRMIDHGQIVATPFRDIYTIVPKMAESKAFAFRVQLPTNTGVQDIKNLTLRMLGTKTSDGAYHVHLKPKMIIPLSLPLEMLQLNPEVKVIRVFKANPKHNEPQLALLQINVMGHVNADLNNRIAEKPRQPFTLPFPEQKSIFFAATRTKNGYRRAFLLDHIVKPRPTYLVYEMDEGRVSIATDLSRIPSELLGLPSRVFAAQLEDSVPEELETQGAELTVKFKLDNKPPKEKLRAANAALNSKGEQICMARLITFLGQISYLGHKYWREPIVHDSIVFISHLVSFKEVYISTPDAKQYAEIFKRLEYKCATITKSSDVSVGSIVLVVSKQMGHFRGEILSKDSGLFEVMNVDTGATQKVELAEIRSSCRFLENMPVCLMRVQLQNVCNIPDAAVPVNNAAIQMLHKLCAQKELLKLNMVDATTSTVDLLFSSGDSRSLTTQMLPLIFTPVQEKAEVAPPKAASTPSQLPVVTHKQQKVSPQSLLLLDLPPLPPSPPESPSPADVPTKKSASHVLPIKRFLFDALPKNLAPLGDKVNLILMNADGLPQTGYITAAYFKDEKAAKEFEKILSLTSSQGACDHNVVPGYVPNVGELCLAIYSEDKNWYRGVCQEVKDNMVKILFCDFGNTEYVAVRHVKPISQDLLIAVNVTKCYINGFDKSKNFAALEQFLVRKIRFLCGVKKGPEPDTRLITIPDMETILNTPVA