wanglab/gogpt-training-data huggingface dataset:
Protein: Mitochondrial nucleoid factor 1 (Mitochondrial protein M19) (Q5TAQ0)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00004436}.
Interaction partners:
Sequence:
MAASRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQYPRPRDTSFSGLSLEEYKLILSTDTLEELKEIDKGMWKKLQEKFAPKGPEEDHKA
Protein: hydroxymethylbilane synthase (EC 2.5.1.61) (Hydroxymethylbilane synthase) (Q8I5V3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Delta-aminolevulinic acid dehydratase
- Uroporphyrinogen decarboxylase
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Ferrochelatase
- NADH-cytochrome b5 reductase, putative
- Protoporphyrinogen oxidase
- coproporphyrinogen oxidase
- Protein kinase, putative
Sequence:
MHLLSFLSFIIWFIHCTAKRHEYSIKKYFLNSHNFCKIKPDPFRKDTLKKRLYSSDGIKDEIIIGTRDSPLALKQSEKVRKKIMSYFKKMNKNINVTFKYIKTTGDNILDSKSVGLYGGKGIFTKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSINDMNTVKSVSKTEDIHHINKKDSDHNNDTLCTIGTSSLRRRSQIKNRYKNIYVNNIRGNINTRIEKLYNGEVDALIIAMCGIERLIKKANLKHLLKNKEQKNICQPFLLKCNNKKCIDLCHVNIQKLNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDGNCMMPIGGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIGPNAAIKMKEIIGTEQFNKIKAEAELHLLNNK
Protein: Branched-chain amino acid ABC transporter, permease protein (Q5LSB8)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Branched-chain amino acid ABC transporter, permease protein
- Branched-chain amino acid ABC transporter, ATP-binding protein
- Branched-chain amino acid ABC transporter, ATP-binding protein
- Branched-chain amino acid ABC transporter, permease protein
- Branched-chain amino acid ABC transporter, ATP-binding protein
- Branched-chain amino acid ABC transporter, ATP-binding protein
- Branched-chain amino acid ABC transporter, ATP-binding protein
- Branched-chain amino acid ABC transporter, ATP-binding protein
- Branched-chain amino acid ABC transporter, ATP-binding protein
- Branched-chain amino acid ABC transporter, ATP-binding protein
Sequence:
MRIVFKTDYMQDIRPWKDGYQLGLYMILLAIVVAAPWLLDAFYLGELTNVLIWAIAGMGLMVLTGHTGQASLGHAAFLAFGCYANVILLEAGVPFIIAFPLAGVITGLIGATVAIPALRLHGIYLAIFTLALSILVDDIIVLSEPWTGGVSGKYVAGIDLFGLTIDRWGTPMLFYWLVLAVTVIVALGYINLLRSPLGRSFIAVRDSEVSAQAMGVDIARAKTISFGLSCMVTGWAGAFMGLFAGAFNNETFSVVISIELLMMIVIGGLGSIHGAFFGAIVIGFLPQFLSIAKEYVGAVFGGSTVAIPGLEFGIFGMILIAFILLEPMGIYGRWLKIRTFFELFPFYRKDMFKRQKSYLKTERLR
Protein: Nuclear protein 2 (Nuclear transcriptional regulator 1-like protein) (Nuclear transcriptional regulator protein 2) (A6NF83)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells. Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation. Plays a role as a negative regulator of the protumoral factor NUPR1.
Subcellular location: Nucleus {ECO:0000269|PubMed:25899918}.
Interaction partners:
- Telomeric repeat-binding factor 1
- Protection of telomeres protein 1
- Tripeptidyl-peptidase 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- Adrenocortical dysplasia protein homolog
Sequence:
MEAPAERALPRLQALARPPPPISYEEELYDCLDYYYLRDFPACGAGRSKGRTRREQALRTNWPAPGGHERKVAQKLLNGQRKRRQRQLHPKMRTRLT
Protein: Csl4p homologue (Q95Z17)
Organism: Trypanosoma brucei
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MAVIVKTGKCVSPGDVLYATDIYDAIGTIVVAASDTGAVSAGNHADDAIIAGTGCYSRVVSKPDGAVSSQIITTLLGIVQWSGNVVSVRQPTKRARDATTIEVVSLNALKDAGTCGDSATPRLSTPGEATSSVSETPASTAVSTAPKSLWISTSVFGPRMGDNVHLRVVRVSRSFAYGEIIAVNGTWCSNSGSNGGGGGALGGFRGVIRMEDIRPFKPRKDQLTPPPPADAFQDGDVVVATVLSQSDVRQYQLSTVAEHCGVVEAFTVLNSNGRERRVRLRHIPECRDIMKCPLSGNLHRRWCPLIRLV
Protein: Diphosphomevalonate decarboxylase MVD1, peroxisomal (EC 4.1.1.33) (Mevalonate 5-diphosphate decarboxylase 1) (AtMDD1) (AtMVD1) (O23722)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Is specific for (R)-5-diphosphomevalonate (MVAPP). The catalytic efficiency with (R)-5-phosphomevalonate (MVAP) as substrate is 10000-fold lower than for MVAPP. Can complement a yeast mutant defective in MVD activity.
Subcellular location: Peroxisome {ECO:0000269|PubMed:21655959}.
Interaction partners:
- Mevalonate kinase
- Phosphomevalonate kinase, peroxisomal
- Isopentenyl-diphosphate Delta-isomerase I, chloroplastic
- Isopentenyl-diphosphate Delta-isomerase II, chloroplastic
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- Hydroxymethylglutaryl-CoA synthase
- Farnesyl pyrophosphate synthase 2
- Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial)
- Farnesyl pyrophosphate synthase 1, mitochondrial
- Acetyl-CoA acetyltransferase 1
Sequence:
MAEEKWVVMVTAQTPTNIAVIKYWGKRDEVRILPINDSISVTLDPDHLCTLTTVAVSPSFDRDRMWLNGKEISLSGSRYQNCLREIRSRADDVEDKEKGIKIAKKDWEKLHLHIASHNNFPTAAGLASSAAGFACLVFALAKLMNVNEDPSQLSAIARQGSGSACRSLFGGFVKWNMGNKEDGSDSVAVQLVDDKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSLLLQHRAKEVVPVRILQMEEAIKNRDFTSFTKLTCSDSNQFHAVCMDTSPPIFYMNDTSHRIISLVEKWNRSAGTPEIAYTFDAGPNAVMIARNRKVAVELLQGLLYCFPPKPDTDMKSYVLGDTSIVKEAGLEGELPQGIKDKIGSQDQKGEVSYFICSRPGRGPVVLQDQTQALLHPQTGLPK
Protein: Protein bicaudal D homolog 2 (Bic-D 2) (Q921C5)
Organism: Mus musculus (Mouse)
Function: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex. Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:11483508, ECO:0000269|PubMed:12447383, ECO:0000269|PubMed:25962623}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11483508}. Cytoplasm {ECO:0000250|UniProtKB:Q8TD16}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q8TD16}. Nucleus envelope {ECO:0000250|UniProtKB:Q8TD16}. Note=In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (PubMed:11483508). Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (By similarity). {ECO:0000250|UniProtKB:Q8TD16, ECO:0000269|PubMed:11483508}.
Interaction partners:
- Cytoplasmic dynein 1 light intermediate chain 1
- E3 SUMO-protein ligase RanBP2
- Dynactin subunit 1
- Cytoplasmic dynein 1 heavy chain 1
- Dynactin subunit 2
- Ras-related protein Rab-6A
- Cytoplasmic dynein 1 intermediate chain 1
- Protein Hook homolog 3
- Cytoplasmic dynein 1 light intermediate chain 2
- Protein bicaudal D homolog 1
Sequence:
MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLTSVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLDGLKFSDDTVTAEPNNDAEALVNGFEHSGLVKSSLDNKTSTPRKDGLAPPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVNRLTENLSALRRLQAGKERQTSLDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKISLLEKASHQDRELLAHLEKELKKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGKAGRTSPEGRGRRSPVLLPKGLLATEVGRADGGTGDNSPSPSSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRSKAASKAKPASPSL
Protein: Indole-3-acetic acid-amido synthetase GH3.6 (EC 6.3.2.-) (Auxin-responsive GH3-like protein 6) (AtGH3-6) (Protein DWARF IN LIGHT 1) (DFL-1) (Q9LSQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin. Strongly reactive with Glu, Gln, Trp, Asp, Ala, Leu, Phe, Gly, Tyr, Met, Ile and Val. Little or no product formation with His, Ser, Thr, Arg, Lys, or Cys. Also active on pyruvic and butyric acid analogs of IAA, PAA and the synthetic auxin naphthaleneacetic acid (NAA). The two chlorinated synthetic auxin herbicides 2,4-D and 3,6-dichloro-o-anisic acid (dicamba) cannot be used as substrates. Involved in auxin signal transduction. Inhibits shoot and hypocotyl cell elongation, and lateral root cell differentiation in light.
Interaction partners:
- Auxin response factor 8
- Auxin response factor 17
- Auxin transporter protein 1
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin-responsive protein IAA9
- Auxin transporter-like protein 2
- Auxin response factor 5
Sequence:
MPEAPKIAALEVSDESLAEKNKNKLQFIEDVTTNADDVQRRVLEEILSRNADVEYLKRHGLEGRTDRETFKHIMPVVTYEDIQPEINRIANGDKSQVLCSNPISEFLTSSGTSGGERKLMPTIEEELDRRSLLYSLLMPVMDQFVPGLDKGKGMYFLFIKSESKTPGGLPARPVLTSYYKSSHFKNRPYDPYTNYTSPNQTILCSDSYQSMYSQMLCGLCQHKEVLRVGAVFASGFIRAIKFLEKHWPELARDIRTGTLSSEITDSSVREAVGEILKPDPKLADFVESECRKTSWQGIITRLWPNTKYVDVIVTGTMSQYIPTLDYYSNGLPLVCTMYASSECYFGVNLRPLCKPSEVSYTLIPNMAYFEFLPVHRNSGVTSSISLPKALTEKEQQELVDLVDVKLGQEYELVVTTYAGLYRYRVGDVLSVAGFKNNAPQFSFICRKNVVLSIDSDKTDEVELQNAVKNAVTHLVPFDASLSEYTSYADTSSIPGHYVLFWELCLNGNTPIPPSVFEDCCLTIEESLNSVYRQGRVSDKSIGPLEIKMVESGTFDKLMDYAISLGASINQYKTPRCVKFAPIIELLNSRVVDSYFSPKCPKWSPGHKQWGSN
Protein: Protein FAM72B (Q86X60)
Organism: Homo sapiens (Human)
Interaction partners:
- Protein FAM72C
Sequence:
MSTNICSFKDRCVSILCCKFCKQVLSSRGMKAVLLADTEIDLFSTDIPPTNAVDFTGRCYFTKICKCKLKDIACLKCGNIVGYHVIVPCSSCLPSCNNGHFWMFHSQAVYDINRLDSTGVNILLWGNLPEIEESTDEDVLNISAEECIR
Protein: Protein C2-DOMAIN ABA-RELATED 7 (Q9SSL1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stimulates the GTPase/ATPase activities of Obg-like ATPases (By similarity). Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9FHP6}. Nucleus {ECO:0000250|UniProtKB:Q9FHP6}.
Interaction partners:
- FT-interacting protein 3
- FRIGIDA-like protein 3
- Classical arabinogalactan protein 6
- CBS domain-containing protein CBSX3
Sequence:
MEELVGLLRIRVKRGINLAQRDTLSSDPFVVITMGSQKLKTRVVENNCNPEWNEELTLALRHPDEPVNLIVYDKDTFTSHDKMGDAKIDIKPFLEVHKMGLQELPDGTEIKRVVPNRENCLAEASSIVSNNGKIVQNMILLLRNVECGEVEIQLEWIDIPGSRGL
Protein: Type III effector HopAI1 (Q888W0)
Organism: Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Interaction partners:
- HopF
- Effector protein HopAB2
Sequence:
MLALKLNTSIAQAPLKKNAEAELRHMNHAEVRAHTPTRFTLNHRAPTYEVAQSALGENHGGWTAVNKFKVTESEVFIHMERSDSRSKGDFAGDKIHLSVAPQHVASAFNAIGKILQADDSPVDKWKVTDMSCASSDLQPEKKRVTQGAQFTLYAKPDRADNTYSPEYMGKMRGMISSIERELHTAGVQQSNNRPASDVAPGHWAYASYRNEHRSERAGSSSQANELEKEPFFQLVSFPDVAASPVKSGASSRSLMPPPWTR
Protein: Cadherin 8 (X6R3Y6)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRLQKRVARRNITRCCLKRKTVENHGFNELRGQDQKRK
Protein: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1 (NAPE-1) (EC 3.1.4.54) (Q965X7)
Organism: Caenorhabditis elegans
Function: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. NAEs are bioactive lipids that are involved in diverse physiological processes such as growth and lifespan.
Interaction partners:
- Fatty acid amide hydrolase 1
- Amidase domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- Monoglyceride lipase faah-4
Sequence:
MSLPTTSSPLTNDQEFAKPVRNGKIFENPKSFTNWGGRPGLTNIFKLVLRETSHENLPSDKKVLDSTLPVHNITADDFHSESGLFATWLGHATVLVDLEGVKFVTDPVWADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHLDADAVKRITNLNPQIKWFVPLGLKKWMKNQGIGADGSNTVTELNWGESSEFVKNGKTITIWCLPAQHSGQRGLSDHNHRLWSGWAVIGENRRFYFPGDTGFCDVEFKKIGEKLGPFDLAAIPIGAYEPRWFMKSHHINPDEAVEVHKLVRARNSIGIHWGTYPMGTTEYYLEPRDKLKELMDAREDLKDTSFVTVDMGEIWEASDR
Protein: Protein GOLVEN 4 (CLAVATA3/ESR (CLE)-related protein CLEL4) (CLE-Like protein 4) (Root meristem growth factor 7) (AtRGF7) [Cleaved into: GLV4p] (Q6NNL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Signaling peptide (root growth factor) that promotes root hairs formation and growth. Maintains the postembryonic root stem cell niche. Regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells (By similarity).
Subcellular location: [GLV4p]: Secreted {ECO:0000250|UniProtKB:Q3E880}.
Interaction partners:
- Protein GOLVEN 11
- Protein GOLVEN 9
- Protein GOLVEN 10
- Protein GOLVEN 2
- Precursor of CEP12
- LRR receptor-like serine/threonine-protein kinase RGI3
Sequence:
MEMKKWSYANLITLALLFLFFIILLLAFQGGSRDDDHQHVHVAIRTKDISMGRKLKSLKPINPTKKNGFEYPDQGSHDVQEREVYVELRDYGQRKYKPPVHN
Protein: Beta-phosphoglucomutase (Beta-PGM) (EC 5.4.2.6) (P71447)
Organism: Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Function: Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MFKAVLFDLDGVITDTAEYHFRAWKALAEEIGINGVDRQFNEQLKGVSREDSLQKILDLADKKVSAEEFKELAKRKNDNYVKMIQDVSPADVYPGILQLLKDLRSNKIKIALASASKNGPFLLEKMNLTGYFDAIADPAEVAASKPAPDIFIAAAHAVGVAPSESIGLEDSQAGIQAIKDSGALPIGVGRPEDLGDDIVIVPDTSYYTLEFLKEVWLQKQK
Protein: Forkhead box protein O6 (A8MYZ6)
Organism: Homo sapiens (Human)
Function: Transcriptional activator.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}. Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity). {ECO:0000250}.
Interaction partners:
- RAC-alpha serine/threonine-protein kinase
- Plexin-A4
- Forkhead box protein O4
- RAC-beta serine/threonine-protein kinase
- Glucose-6-phosphatase catalytic subunit 1
Sequence:
MAAKLRAHQVDVDPDFAPQSRPRSCTWPLPQPDLAGDEDGALGAGVAEGAEDCGPERRATAPAMAPAPPLGAEVGPLRKAKSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMDNGAKFLRIKGKASKKKQLQAPERSPDDSSPSAPAPGPVPAAAKWAASPASHASDDYEAWADFRGGGRPLLGEAAELEDDEALEALAPSSPLMYPSPASALSPALGSRCPGELPRLAELGGPLGLHGGGGAGLPEGLLDGAQDAYGPRPAPRPGPVLGAPGELALAGAAAAYPGKGAAPYAPPAPSRSALAHPISLMTLPGEAGAAGLAPPGHAAAFGGPPGGLLLDALPGPYAAAAAGPLGAAPDRFPADLDLDMFSGSLECDVESIILNDFMDSDEMDFNFDSALPPPPPGLAGAPPPNQSWVPG
Protein: Protein disulfide-isomerase 1 (PDI1) (EC 5.3.4.1) (Q86IA3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:9428745}.
Interaction partners:
- Endoplasmic reticulum oxidoreductin-1
- Probable tetraspanin tspD
- Probable tetraspanin tspA
Sequence:
MKILLFVTLIALAFVALCSAEGNVVVLSPDNFDTVVDGSKTVFVKFYAPWCGHCKKLAPDFEILADTFAPVSNKVVIAKVDCDQADNKALCSKYDVSGYPTLKIFDKSTTAKDYNGARSVDELLTYINNHAKTNVKVKKAPSNVVDLSPSNFDSVVLDKSKNVLVEFYAPWCGHCKKLMPDYEILGNTYANEKDVVIAKIDCDAADNKAICSKYGVTGFPTLKWFGKQSKDGEKYEQGRDLDTFINYINKQAGVNRVKGGKLAVGAGRVEQLDTIATEFIAAAAEVRKELVKKAQTVVDSLPEELRTEGSYYVKVMKTIAEKSIDFVTTEIARITKLVSGSMSGKKADEFAKKLNILESFKSK
Protein: Solanidine glucosyltransferase (G9JKC3)
Organism: Solanum tuberosum (Potato)
Interaction partners:
Sequence:
MDNGSKQLHVLFLPYFATGHIIPLVNAARLFASRDGVKVTILTTHHNASLFRSSIDNSLISIVTLKFPSTEVGLPEGIENFSSASSTEIAGKVFGGTYLLQKPMEDKIREIHPDCIFSDMYFPWTVDIALELKIPRLLFN
Protein: DNA repair protein RAD51 homolog (F7EX62)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364139}.
Interaction partners:
Sequence:
MAMQMQLEANADTSNDVKKLEEAGYHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARGFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
Protein: Protein FATTY ACID EXPORT 6 (At-FAX6) (Q9LJU6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in free fatty acids export.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein FATTY ACID EXPORT 4, chloroplastic
- Outer envelope protein 61
- Protein FATTY ACID EXPORT 3, chloroplastic
Sequence:
MHDFCFTIPYGMLLIGGGFIGYMKKGSITSFAGGAGTGLLLILAGYISLKAFEKKKNSTIAMVLQTVIAAALTLVMGQRYLLTGKIMPAGLVAGISALMTCFYVYKIATGGNKFPAKAE
Protein: IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor) (P55899)
Organism: Homo sapiens (Human)
Function: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:31104841}.
Interaction partners:
- Beta-2-microglobulin
- Albumin
- Immunoglobulin lambda-like polypeptide 5
- Immunoglobulin heavy variable 3-43D
- Probable non-functional immunoglobulin heavy variable 3-16
- High affinity immunoglobulin gamma Fc receptor I
- Low affinity immunoglobulin gamma Fc region receptor II-b
- Low affinity immunoglobulin gamma Fc region receptor II-a
- Low affinity immunoglobulin gamma Fc region receptor III-A
- Somatotropin
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
Protein: Rifin (C6KTF3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKIHYINILLFALPLNILVNNQRNHNNSTYHTSNTKTIKSHRSLCESKLYAQSNYENDQEMKDVIKEFNDRTAQRFEEYNERMQVKKNQCKEQCDKEIQQIILKDKIEKELTERFSALETKIDTNDILTCICEKSVADKVEKTCVKCGRILGTAVPELSLIGGIAVYAAAQSATMKTFISETIDVLNRIGGMSQLFGAKISQFVTPSIYGKPMNLVIPLQEAINNACKCPDMGDKILCGGIERSFEQNLPARIAYAVNQGVDTANDTWATATTPTTFLTNPFVASSIAIMIIVAIVLIIYLILRYRRKQKIKKKLQYIKLLKE
Protein: 4-coumarate--CoA ligase 3 (4CL 3) (Os4CL3) (EC 6.2.1.12) ((E)-ferulate--CoA ligase) (EC 6.2.1.34) (4-coumaroyl-CoA synthase 3) (Q6ETN3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in the phenylpropanoid metabolism by mediating the activation of a number of hydroxycinnamates for the biosynthesis of monolignols and other phenolic secondary metabolites. Catalyzes the formation of CoA esters of cinnamate, 4-coumarate, caffeate and ferulate. Is more efficient with substrates in the following order: ferulate > 4-coumarate > caffeate > cinnamate. Possesses very high activity compared to 4CL1, 4CL2, 4CL4 and 4CL5. Cannot convert sinapate to its corresponding CoA ester. May play a role in the synthesis of lignin as well as other phenolic compounds. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester (By similarity).
Interaction partners:
- Phenylalanine ammonia-lyase
- tricin synthase
- Phenylalanine ammonia-lyase
- Aldehyde dehydrogenase 1
- Os06g0592400 protein
- Phenylalanine ammonia-lyase
- Hydroxycinnamoyltransferase 1
- Aldehyde dehydrogenase 1
- Trans-cinnamate 4-monooxygenase
- Os08g0205000 protein
Sequence:
MGSVAAEEVVVFRSKLPDIEIDNSMTLQEYCFARMAEVGARPCLIDGQTGESYTYAEVESASRRAAAGLRRMGVGKGDVVMSLLRNCPEFAFSFLGAARLGAATTTANPFYTPHEVHRQAEAAGARVIVTEACAVEKVREFAAERGVPVVTVDGAFDGCVEFREVLAAEELDADADVHPDDVVALPYSSGTTGLPKGVMLTHRSLITSVAQQVDGENPNLYFSKDDVILCLLPLFHIYSLNSVLLAGLRAGSTIVIMRKFDLGALVDLVRKHNITIAPFVPPIVVEIAKSPRVTAEDLASIRMVMSGAAPMGKDLQDAFMAKIPNAVLGQGYGMTEAGPVLAMCLAFAKEPFKVKSGSCGTVVRNAELKIVDPDTGTSLGRNQSGEICIRGEQIMKGYLNDPEATKNTIDEDGWLHTGDIGFVDDDDEIFIVDRLKEIIKYKGFQVPPAELEALLITHPEIKDAAVVSMKDDLAGEVPVAFIVRTEGSEITEDEIKKFVAKEVVFYKRINKVFFTDSIPKNPSGKILRKDLRARLAAGIPDAVAAAAADAPKSS