wanglab/gogpt-training-data huggingface dataset:
Protein: 60S ribosomal protein L4 (Q8I431)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 40S ribosomal protein S8
- 60S ribosomal protein L13, putative
- 40S ribosomal protein S4
- 40S ribosomal protein S19
- 40S ribosomal protein S17, putative
- 60S ribosomal protein L30e, putative
- 60S acidic ribosomal protein P0
- 40S ribosomal protein S7
- 40S ribosomal protein S15
- 60S ribosomal protein L27
Sequence:
MATIRPVANVYSTNGKNVVGEVEIPVVFQTPIRNDLIQSVYTNMSKNRRHPYAVKLGAGYETSAESWGTGRAVARIPRVPGGGTHRAGQGAFGNMCRGGGMFNPTKIWRRWGRKVNLKEKRYAVCSSIAASGVTSLVLARGHRISHLKEVPLVVSNDIESLSKTKEAVNFLVSLGLKDEVNRLVKSKKIRAGKGKMRNRKYKIRNGPLIIYENDNGVKKAFRNIPGVDLCKVTKLNLLKLAPGGSIGRLCIWSESAFKKLDVIYGKIHEKKVTKKNYILPKSIVHNPDIYRIIHSDKVQASLLAKKKPCKKRLQNKNSLTNFAVRCRLNPAYKLLRSLAVLRMRKSILEKSKNKKEKRVQKQIQKKELQKINHDYYKGVAKAVKKKKKREEKKAKSKKTANQAVINVAAEE
Protein: Septin-11 (Q8C1B7)
Organism: Mus musculus (Mouse)
Function: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17546647}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17546647}. Synapse {ECO:0000269|PubMed:17546647}. Cell projection, dendritic spine {ECO:0000269|PubMed:17546647}. Cell projection, axon {ECO:0000250}.
Interaction partners:
- Septin-7
- Septin-9
- Septin-2
- Septin-5
- Septin-6
- Septin-8
- Septin-4
- Neuronal-specific septin-3
- Septin-10
- Septin-1
Sequence:
MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVSNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNPWLCTE
Protein: DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase) (Q9NP87)
Organism: Homo sapiens (Human)
Function: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA repair protein REV1
- Terminal nucleotidyltransferase 4A
- DNA polymerase eta
- DNA repair protein XRCC4
- DNA polymerase iota
- DNA ligase 4
- DNA-dependent protein kinase catalytic subunit
- Non-homologous end-joining factor 1
- X-ray repair cross-complementing protein 6
- E3 ubiquitin-protein ligase RAD18
Sequence:
MLPKRRRARVGSPSGDAASSTPPSTRFPGVAIYLVEPRMGRSRRAFLTGLARSKGFRVLDACSSEATHVVMEETSAEEAVSWQERRMAAAPPGCTPPALLDISWLTESLGAGQPVPVECRHRLEVAGPRKGPLSPAWMPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLLTFCRAASVLKALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQTMKLFTQIFGVGVKTADRWYREGLRTLDDLREQPQKLTQQQKAGLQHHQDLSTPVLRSDVDALQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLITHPKEGQEAGLLPRVMCRLQDQGLILYHQHQHSCCESPTRLAQQSHMDAFERSFCIFRLPQPPGAAVGGSTRPCPSWKAVRVDLVVAPVSQFPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQKTFFQAASEEDIFRHLGLEYLPPEQRNA
Protein: BTB domain-containing protein (H2KZE8)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSTERLMYLDLNKGNQIAMVIPSTRKGHAASRDNFGNSNHHGDEIVHRLNNGRRSEIDEVKPDLVSGAGDTVIKLNVGGTSFRIRISSIFARSADEKLSAFAQLNHEQRLQACDAFLMPQEEYYLERSAVLFDSIFKYYISGQLHRPLDVCPTEFATELAYWKINDGLMSNCCWRGYNMSPSLEELVAPKEKKIELHDRSMRSRIHQFCEGDGSLFSTLFTFGSITFVLISVIGLVLGSIHEFQVPIYKKGGKSERISNWSIVENENIIWEPHPIFGYVETVCIIWFTVEFIVRLAVTPNRFQFLVGIMNIVDMIAIIPFYLELGLALFGIDVASLSDIKGALLVVRVLRVLRVVRILKLGRYSSGMRTFALTLKSSARQLGMMGMVLSTGVVFFSTLLYFVEKDEKDTPFTSIPAAFWWAIVTMTTVGYGDYVPVTVPGKLIASGAIISGVLVLALPITIIVDNFMKVSGNIDTQE
Protein: Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) (Q5SQX6)
Organism: Mus musculus (Mouse)
Function: Part of the WAVE1 complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity). Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11438699}. Nucleus {ECO:0000250|UniProtKB:Q96F07}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11438699}. Synapse, synaptosome {ECO:0000269|PubMed:11438699}. Note=Highly expressed in the perinuclear region and enriched in synaptosomes (PubMed:11438699). {ECO:0000269|PubMed:11438699}.
Interaction partners:
- Abl interactor 2
- Nck-associated protein 1
- RNA-binding protein FXR1
- Actin-binding protein WASF1
- Abl interactor 1
- RNA-binding protein FXR2
- Nck-associated protein 1-like
- Protein BRICK1
- Fragile X messenger ribonucleoprotein 1
- Actin-binding protein WASF2
Sequence:
MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHDYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC
Protein: Forkhead box A1 (Foxa1 protein) (Hepatocyte nuclear factor 3-alpha) (Q6P0C9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
- Transcription factor GATA-3
- Transducin-like enhancer protein 3-B
- Estrogen receptor
- E1A-binding protein p300 b.
- Nuclear receptor-interacting protein 1
- GATA-binding protein 6
- GATA-binding protein 4.
- One cut domain family member
- SRY-box containing gene 17
- Hematopoietically-expressed homeobox protein hhex
Sequence:
MLGAVKMEGHETPDWSSYYNDAQEVYSPMTNSSMNPGLSSMNNMNSYMGMSTSGNMTSSSFNMSYANPALGAGLSPGTMAGMPTGGAMNGMGGGVSSMGTALSPSNLNAMTAQHSSMNALNPYTSMSPTMSSMTYAQPNLNRARDNKTFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVSRSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCDKKLPDGKRSEGKREQSSGSGSPASDSTSSKPVHMDSSSITSSNQSSSPPSLDHRSGSSANSELKSGGPQVHPVSTSLSSLHSMAHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLELKAYEQALQYSSYGSGMSSNLPMAGRASMDPSAALEASYYQGVYSRPVLNTS
Protein: Malate dehydrogenase (EC 1.1.1.37) (Q4Q7X6)
Organism: Leishmania major
Interaction partners:
- Probable citrate synthase, mitochondrial
- Citrate synthase
- Putative malic enzyme
- Fumarate hydratase 1, mitochondrial
- Fumarate hydratase 2
- phosphoenolpyruvate carboxykinase
- phosphoenolpyruvate carboxykinase
- Transaminase A
- Aspartate aminotransferase
- Pyruvate kinase
Sequence:
MSAVKVAVTGAAGQIGYALVPLIARGALLGPTTPVELRLLDIEPALKALAGVEAELEDCAFPLLDKVVVTADPRVAFDGVAIAIMCGAFPRKAGMERKDLLEMNARIFKEQGEAIAAVAASDCRVVVVGNPANTNALILLKSAQGKLNPRHVTAMTRLDHNRALSLLARKAGVPVSQVRNVIIWGNHSSTQVPDTDSAVIGTTPAREAIKDDALDDDFVQVVRGRGAEIIQLRGLSSAMSAAKAAVDHVHDWIHGTPEGVYVSMGVYSDENPYGVPSGLIFSFPCTCHAGEWTVVSGKLNGDLGKQRLASTIAELQEERAQAGL
Protein: L-type lectin-domain containing receptor kinase IV.1 (Arabidopsis thaliana lectin-receptor kinase e) (AthlecRK-e) (LecRK-IV.1) (EC 2.7.11.1) (Lectin Receptor Kinase 1) (O80939)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- RHOMBOID-like protein 6, mitochondrial
- Protein LURP-one-related 4
- Protein TORNADO 1
Sequence:
MFLKLLTIFFFFFFNLIFQSSSQSLNFAYNNGFNPPTDLSIQGITTVTPNGLLKLTNTTVQKTGHAFYTKPIRFKDSPNGTVSSFSTSFVFAIHSQIAILSGHGIAFVVAPNASLPYGNPSQYIGLFNLANNGNETNHVFAVELDTILSTEFNDTNDNHVGIDINSLKSVQSSPAGYWDEKGQFKNLTLISRKPMQVWVDYDGRTNKIDVTMAPFNEDKPTRPLVTAVRDLSSVLLQDMYVGFSSATGSVLSEHYILGWSFGLNEKAPPLALSRLPKLPRFEPKRISEFYKIGMPLISLFLIFSFIFLVCYIVRRRRKFAEELEEWEKEFGKNRFRFKDLYYATKGFKEKGLLGTGGFGSVYKGVMPGTKLEIAVKRVSHESRQGMKEFVAEIVSIGRMSHRNLVPLLGYCRRRGELLLVYDYMPNGSLDKYLYNTPEVTLNWKQRIKVILGVASGLFYLHEEWEQVVIHRDVKASNVLLDGELNGRLGDFGLARLYDHGSDPQTTHVVGTLGYLAPEHTRTGRATMATDVFAFGAFLLEVACGRRPIEFQQETDETFLLVDWVFGLWNKGDILAAKDPNMGSECDEKEVEMVLKLGLLCSHSDPRARPSMRQVLHYLRGDAKLPELSPLDLSGSGMMFGVHDGFSELGMSYSSSVFKGFTGGSSIADSQLSGGR
Protein: Effector protease OspD3 (EC 3.4.-.-) (Q99Q01)
Organism: Shigella flexneri
Function: Effector protease that disrupts necroptosis in host cells by mediating proteolytic cleavage of host RIPK1 and RIPK3.
Subcellular location: Secreted {ECO:0000305|PubMed:32657447}. Note=Secreted via the type III secretion system (T3SS). {ECO:0000305|PubMed:32657447}.
Interaction partners:
Sequence:
MPSVNLIPSRKICLQNMINKDNVSVETIQSLLHSKQLPYFSDKRSFLLNLNCQVTDHSGRLIVCRHLASYWIAQFNKSSGHVDYHHFAFPDEIKNYVSVSEEEKAINVPAIIYFVENGSWGDIIFYIFNEMIFHSEKSRALEISTSNHNMALGLKIKETKNGGDFVIQLYDPNHTATHLRAEFNKFNLAKIKKLTVDNFLDEKHQKCYGLISDGMSIFVDRHTPTSMSSIIRWPDNLLHPKVIYHAMRMGLTELIQKVTRVVQLSDLSDNTLELLLAAKNDDGLSGLLLALQNGHSDTILAYGELLETSGLNLDKTVELLTAEGMGGRISGLSQALQNGHAETIKTYGRLLKKRAINIEYNKLKNLLTAYYYDEVHRQIPGLMFALQNGHADAIRAYGELILSPPLLNSEDIVNLLASRRYDNVPGLLLALNNGQADAILAYGDILNEAKLNLDKKAELLEAKDSNGLSGLFVALHNGCVETIIAYGKILHTADLTPHQASKLLAAEGPNGVSGLIIAFQNRNFEAIKTYMGIIKNENITPEEIAEHLDKKNGSDFLEIMKNIKS
Protein: Dynein axonemal assembly factor 6 (PIH1 domain-containing protein 3) (Q3KNI6)
Organism: Mus musculus (Mouse)
Function: Plays a role in cytoplasmic pre-assembly of axonemal dynein.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24421334}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9NQM4}. Note=Localized to the cytoplasm of spermatogenic cells. {ECO:0000269|PubMed:24421334}.
Interaction partners:
- Dynein axonemal assembly factor 4
- PIH1 domain-containing protein 2
- Sperm-associated antigen 1
- Dynein axonemal assembly factor 11
- Dynein axonemal assembly factor 3
- Dynein axonemal assembly factor 1
- Dynein axonemal intermediate chain 2
- Dynein axonemal assembly factor 5
- RNA polymerase II-associated protein 3
- Axonemal dynein light intermediate polypeptide 1
Sequence:
MESENAEAENVVTGNLEAKSKEGKNMQFVTLSSAWSLQALSSLLNPEEEDGFDFEQGQCSFTIGAMGPGNIGPPKAKESKAIPEPRSDESENIWNPEEVPEGAEHDDIWDVREIPDYEIVFQQTVGTEDVYLGLTRKDPSTACCQELVVKIKLPNTNPSEIQIDIQEMLLDLRTPRKKLLVNFPQPVERNSARASYIWEAETLEVRMTVQRDLDFNIS
Protein: Uncharacterized protein (Q38A10)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLSTLFFDGADATSALHVRTTLEDRLGDAPARTAADNVVSYQAMDFPSSGSIPVPSLRATLLWWLDRDEPLVHILLTGSTVGDMSYSSRKLSVELVSPRHTIIACGVTHVRDQAVFAVSWVTSLLEAGALQIQLQRSSDHHSQLLIVPDEQAVLTSRFSGVAAAFEYDASVVQAKSNGNGGNVDDEEGNGSEPTLCASVIASLPQAAAADGLLSVILLSNGCRLWRVEIASDGTFVEHEFKDASGTSDSDGEFLGGSLLPSWLLTWSQDHREKSHRRYIAVSSVQLTHYFAILRSNGSIGLYDDSLSTISSASECALTKDEMVFSHALQWSALIGNDVHVVTSFGRKEIRQCLWARIPIASTSGDDPKTVKMTILPPSSTSTLLGCVAINPTRLSLLWGIGAEEDACIRCSLSVGSLMHANEQGLSGILQIIDAEEELDADGGSISGSCAYSSLREAQTFFCHSKPLHALTAVGEEMVLVEKVDESVRAHVLTSDMSPLEEMLESAFAVTRPVAATTHCTLPLASLHLIPTVVRESGCATAGKLEAFYEGIELAASCAEAADHLSALLINAVHCVPVASTLGGFQLLRSAAHLQGYTPSGFVNEDAIKAAIEHATMFFDVSTRKASFCSYSRHFIQHTIARDLLLRVAYLTCSFIGWMGSDPDYRTSPEIARVRATLELLSAAYHSVSVTGPSTATIVPEVRKTVVDDAIRLFLQFTVGEEAEGNDVLFAVRVANRLRACNEARGPKACATWCNLLSRRYPCLQHFRIIRCIEVGRTSCPSQLAAMCLATTFHLVNCPVPVAKALLLDCGLAIYNDSTFQTAFNGIDVREWWALLDDSGDSNDGKISAVIASVYRVALLRCIVHPGTSHHASASASLVRELFLAELIQLGQHLQESRLDCPGILRALTELRVDTHMFLARAALDDPNFGDAFRSIADVQQIAVGPDIKTVCMEKIGLLIGEVVEIASSSDELTDCLVDVTHCSAELDTLLTSKWYSFIARLAVRSGSTEAEQLRWRAAIGLYRYLCKRHAYGQAGRMMTDLTTAIRCSSLRANVVETVVELTSLAVTAVELISPIAPLQVQDSEPLDGAQESSTFSACSGTGCFFTPEYAAVREPLGREHLPWVRRRHYQAYCEQQLLKANRRVDCTDLWVENPPPAAYAAALRRFVEALMEARLWTEALRFAAMAGADVGLVLQNHALDLMKHTNYTCDEEALEEWVMLVASCEEFSTLSNKYSPLRSTVVTALLCDCEKVCPALLDSLLKADRYEALQALLEVFETLLRRNSFSEGDDMTDGEDRNHDSLTSAACNEEEGDDKSDGAYKPWMLLLKALQIGTAVLMDSLSNEEKFELNEAPMTAGVFDPMVRRASELLNSPLLLQHPSLVKAEGTATNFLKFVGLVKQKKLAGL
Protein: Protein YfiR (P64548)
Organism: Escherichia coli (strain K12)
Function: Repressor of the cell division arrest function of DgcN. Prevents DgcN relocation to the midcell.
Subcellular location: Periplasm {ECO:0000305}.
Interaction partners:
- Diguanylate cyclase DgcN
- Putative lipoprotein YfiB
Sequence:
MRFSHRLFLLLILLLTGAPILAQEPSDVAKNVRMMVSGIVSYTRWPALSGPPKLCIFSSSRFSTALQENAATSLPYLPVIIHTQQEAMISGCNGFYFGNESPTFQMELTEQYPSKALLLIAEQNTECIIGSAFCLIIHNNDVRFAVNLDALSRSGVKVNPDVLMLARKKNDG
Protein: Pickpocket protein 19 (PPK19) (Q9VAJ3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Part of a complex that plays a role in tracheal liquid clearance. In both larvae and adults, contributes to the behavioral response to salt. Probable role in sodium transport.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MLLYTKELVIPRPRPGLLRFRNNPRGIKFREKLCNSFAHSNIHGMQHVFGEQHLWQRCLWLAIVLGAVITGFSLYTVLMHRHSEQLLVSLIETTQLPVYHIDFPAVAVCPWNHFNWQRAPSAFIRFLPRHPNAELRETFRQLLASMDIMNFSNFNRIRILTKRNLTGISYLKMTDLMNFMTYRCDELFVADSCVFDETPYDCCKLFVREQTVKGQCLVFNSMISENSRKKHLINQFYPHKLSTAGEDSGLKFTINASYSFMNNIDALTPFGMNLMIKEPRQWSNEMMYHLYPDTENFVAVHPLVTETSPNTYEMSPKKRRCYFDDEKNPTFQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGINDAQCLGNNSDIFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEMSLNVRKLDYPKNSTDQLIKAQVYYGQRVMTKIITKLKYTNIDLLANFGGIISLYIGASVMSFIELLFVLGKLMWGFIRDARIKLKEYTK
Protein: Cold-responsive protein kinase 1 (EC 2.7.11.1) (Q93YN1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Negative regulator of freezing tolerance that phosphorylates 14-3-3 proteins (e.g. GRF6) thus triggering their translocation from the cytosol to the nucleus in response to cold stress.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28344081}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Basic transcription factor 3
- Transcription factor ICE1
Sequence:
MGCSWLSCHRREATEVDGEIAAIDNVKIYKYREIRQATDDFSAENKIGEGGFGSVYKGCLKDGKLAAIKVLSAESRQGVKEFLTEINVISEIQHENLVKLYGCCVEGNHRILVYNFLENNSLDKTLLAGGYTRSGIQFDWSSRANICVGVAKGLAFLHEEVRPHIIHRDIKASNILLDKYLSPKISDFGLARLMPPNMTHVSTRVAGTIGYLAPEYAVRGQLTRKADIYSFGVLLMEIVSGRSNKNTRLPTEYQYLLERAWELYERNELVDLVDSGLNGVFDAEEACRYLKIGLLCTQDSPKLRPSMSTVVRLLTGEKDIDYKKISRPGLISDFMDLKVRGPVATKTEQVNRQNYTNPSSSSNGSSRDHSNAYSSGASSANAGNTFSSTI
Protein: MutS protein homolog 5 (Q9QUM7)
Organism: Mus musculus (Mouse)
Function: Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity).
Interaction partners:
- MutS protein homolog 4
- DNA topoisomerase 3-alpha
- DNA mismatch repair protein Mlh1
- MutL homolog 3
- RecQ-like DNA helicase BLM
- Breast cancer type 2 susceptibility protein homolog
- Serine-protein kinase ATM
- Histone H2AX
- PMS1 homolog 1, mismatch repair system component)
- Urea transporter 2
Sequence:
MAFRATPGRTPPGPGPRSGIPSASFPSPQPPMAGPGGIEEEDEEEPAEIHLCVLWSSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDEAMTRFLGKLASEEHREPKGPEIILLPSVDFGPEISKQRLLSGNYSFISDSMTATEKILFLSSIIPFDCVLTVRALGGLLKFLSRRRIGVELEDYDVGVPILGFKKFVLTHLVSIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCKWGQKLLRLWFTRPTRELRELNSRLDVIQFFLMPQNLDMAQMLHRLLSHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFQDIAQEFSDDLHHIASLIGKVVDFEESLAENRFTVLPNIDPDIDAKKRRLIGLPSFLTEVAQKELENLDSRIPSCSVIYIPLIGFLLSIPRLPFMVEASDFEIEGLDFMFLSEDKLHYRSARTKELDTLLGDLHCEIRDQETLLMYQLQCQVLARASVLTRVLDLASRLDVLLALASAARDYGYSRPHYSPCIHGVRIRNGRHPLMELCARTFVPNSTDCGGDQGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGVIDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATEHSLVLIDEFGKGTNSVDGLALLAAVLRHWLALGPSCPHVFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGEDLVFFYQLCQGVASASHASHTAAQAGLPDPLIARGKEVSDLIRSGKPIKATNELLRRNQMENCQALVDKFLKLDLEDPTLDLDIFISQEVLPAAPTIL
Protein: EF-hand domain-containing protein 1 (Myoclonin-1) (Q9D9T8)
Organism: Mus musculus (Mouse)
Function: Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (By similarity). May enhance calcium influx through CACNA1E and stimulate programmed cell death. Overexpression of EFHC1 in hippocampal primary culture neurons induced apoptosis. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:E1BKH1}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5JVL4}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q5JVL4}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q5JVL4}.
Interaction partners:
- Tektin-1
- WD repeat-containing protein 90
- Cilia- and flagella-associated protein 52
- Cilia- and flagella-associated protein 45
- Tektin-2
- Parkin coregulated gene protein homolog
- Protein Flattop
- Enkurin
- RIB43A-like with coiled-coils protein 2
- EF-hand domain-containing family member B
Sequence:
MGTNPVHGLPFLPGSSFTDSTKTAFHRSQTLNYRNGYAVVRRPTMGIGGDRLHYNQLSQAELDELANKAPILTYGPLKQAPLAEFVPAHVAFDKKVLKFSAYFQEDVPISMEEHYRIRHVNIYYYLEDDSMSVIEPVVENSGIPQGKLIKRQRFTKNDMGDHYHWKDLNRGINLTVYGKTFRIVDCDRFTQDFLESQGIELNPSEKIPLDPYTQLRKEPVRKYVTPSDFDQLKQFLTFDKQVLRFYAIWDDTDSLFGECRHYIIHYYLMDDTVEIREVHERNNGRDPFPLLMNRQRMPKVLVENAKNFPKCVLEISDQEVLEWYTAKDFIVGKPLTILGRTFFIYDCDPFTRQFYKDKFGMPDLPPVDVTKKEPPPVKQELPPYNGYGLIEDSAQNCFALIPKAPRKDVVKMLMNDNKVLRYLAALESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKFLGRTKVVKSFSPVDNPIYYSPSDFFIGAVIEVFGHRFVILDTDEYVLKYMESNASQYSPEALASIQNRIQKPELPAPELESKQATGEPMVQGTEESKVQDLDALIDQIHMHLKYNSYKENLRETFQMYDKDESGYVDRETFFKICETLNVPVDDSLIKELIRLCTHGEGRINYYNFVRAFSN
Protein: Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (A0A8I5ZVW8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDEKGDKKNQQQQQGNNHTNGTGHPGNQDSGHAQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
Protein: Protein Kish (Q8TGJ3)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the early part of the secretory pathway.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26928762}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:19942856}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Cx9C motif-containing protein 4
- Uncharacterized protein IRC8
Sequence:
MSALFNFRSLLQVILLLICSCSYVHGQWPSLLDRYKNHEVLGAFWKMARVGERASPYVSLACILMAISQFNS
Protein: Protein pdh1 (O42826)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative uncharacterized transmembrane protein C1235.18
- UPF0494 membrane protein C977.06
- Meiotic expression up-regulated protein 31
- Protein efr3
Sequence:
MNHFSKFSVTKRLLILEVLFSAISFGISIYIKVFGRSSIVTFFLLCFHLVPNALFLFPWTIITTSFVDANVFTLLSSILILSVYGVEIERSWGHKEYLLFCQFLTVIPNIAVLIPCFIAYKITDSHYLLVAIIQSTTAIQAGILTAWYQLYSCKKEESSNKFLCPLSKYLIYLFLSIHLFYVFQSFPWTYFCLAVSGTCISELYVLFVHPVVQELFHLESHTQLPI
Protein: Inactive Rho GTPase-activating protein 11B (Rho-type GTPase-activating protein 11B) (Q3KRB8)
Organism: Homo sapiens (Human)
Function: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:31883789}.
Interaction partners:
- Abnormal spindle-like microcephaly-associated protein
- SLIT-ROBO Rho GTPase-activating protein 2C
Sequence:
MWDQRLVKLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGGKIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEEHIHTEGLFRKSGSVIRLKALKNKVDHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKAILLLSCLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNAEKKGVYQTLSWKRYQPCWVLMVSVLLHHWKALKKVNMKLLVNIREREDNV
Protein: Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) (Q9D2V7)
Organism: Mus musculus (Mouse)
Function: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:15327992}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasmic vesicle {ECO:0000269|PubMed:15327992}. Cytoplasm, cytosol {ECO:0000269|PubMed:15327992}. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM16
- Kelch-like protein 20
Sequence:
MSRFKVSKFRHMEARPSRREAWISDIRAVTTPTCGNHIKSSCSLIAFNSDRPGVLGVISLEGHEENKRHVTYLGCHSDLVTDLDFSPFDDFLLASGSADRTIKLWRLSGTGEALPSVPGVVLGPEELPVEVLQFHPTVDGVLVSTAGKTVKVWDVAKQQPLTELEAHKDLVQSAVWSRDGAIVGTACKDKQLRIFDPRARTQASQSTQAHENNRDIRLAWTGIQEHLVSTGFNQMREREAKLWDTRLFSSALASVTLDTSPGPLIPLLDPDSGLLVLAGKGENQLYCYEVTPQQPALSPVTQCILENVLRGAALVPRRALAVMSCEVLQVLQLSDTAIIPISHHVPRKAVEFHEDLFPDTAGSVPASDAHMWWAGDNQQVQKVSLNPARRPHPCFTSSLVPTMEPAPDMVQPAEMPRADTDLSEGFSSPSSLMSPSTPSSLGPSLSSTSGIGTSPSQRSLQSLLGPSSKFRHTQGSLLHRDSHITNLKGLNLTTPGESDGFCANRLRVAVPLLSSGGQVAVLELQKPGRLPDTALPTLQNGTAVMDLVWDPFDPHRLAVAGEDARIRLWRVPPGGLENVLTTPETVLTGHTEKIYSLRFHPLAADVLASSSYDLTVRIWDLQTGAERLKLQGHQDQIFSLAWSPDGKQLATVCKDGHVRVYEPRSSPLPLQEGPGPEGGRGARIVWVCDGGCLLVSGFDSRSERQLQLYIADALAQGPSALLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYEVLPEAPFFLECNSFTSPDPHKGFVLLPKTECDIQDVEFARCLRLRQTSLEPVAFRLPRVRKEFFQDDVFPDTAVTWEPALSAKAWFEGANGQPRLLSLQPPGMTPVSQAPREVPARRAPSSAQYLEEKSDQQKKEELLNAMVAKLGNREDPLPQDSFEGVDEDEWD