wanglab/gogpt-training-data huggingface dataset:
Protein: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (EC 2.4.99.-) (GD1 alpha synthase) (GalNAc alpha-2,6-sialyltransferase V) (ST6GalNAc V) (ST6GalNAcV) (Sialyltransferase 7E) (SIAT7-E) (Q9QYJ1)
Organism: Mus musculus (Mouse)
Function: Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis. Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity).
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein.
Interaction partners:
- Alpha-2,8-sialyltransferase 8E
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Sequence:
MKTLMRHGLAVCLVLTTMCTSLLLVYSSLGSQKERPPQQQQQQQQQQQQAATATGSTQLVESSPQPRRTAPAGPRQLEGYLGVADHKPLKMHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWGPSSYMRRDGKGQAYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRIDVYGMVPPDFCRDPKHPSVPYHYYEPSGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPDWKPESPAVNHAEGKPVF
Protein: Contig An04c0120, genomic contig (EC 3.4.-.-) (A2QIA7)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Interaction partners:
Sequence:
MATPAEPQTAPFGTWDSPITAATLTSKGISFSGIAATADGTIYVNEGRPAEEGRNCIVEWRNNQPRDVLPAAYSARTAVHGYGGAAFNTTSDGKVIFADWKTHGVYILDPATCDVTAAVEPDEKIWYAAFNSHPKRPELVFAIREDHHGKEVVNELVVINTGNKKVEVAATGADFYSHPTFSPAGDRVSWIQWNHPEMPWTGTELFSAPWKDEKVGTPVKLAGNGDEESILQPRWGPDGTLFFVSDRTGYWQFYRWSPDGSDEPRAIVIEGLEKGEFAHPEWLLGSCTYVLPNANTIVAAWTQNATERLVIIDLEKNTYTFPAHIASLTGIQHSAVALTSPTSIAVIASTPTAPSTVYHISLTNNDASAPTVLRSSTSVTISDTYFSRAQHISFPRTISTHPNTLSHAFFLPPTNPKYSSAPGELPPLIITIHGGPTIHTDPGLSMMWQYYTTRGYAVALLNYAGSSGYGRAYRKLLNGSWGVLDVHDAADCARYLISEGKVHPSRIGITGVSSGGYATLQAICMFPTLFTGAVSVSGISDVEALVAETHKFESHYAFRLLFDDKVPETEEEKRKVYRERSPRFHADKIKAKLLLLQGTDDEIVPLNQAQAMADDVQRSGGVAKLVIFEGEGHGYPRKAENGLQAKEVEEGWWKVNLAEVNGE
Protein: adenosine deaminase (EC 3.5.4.4) (Q9GRE6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MGDVEFQNVQEIRGTPQNAMRMIRLELDEEENRRQMSSSKYGGVCFHVAIAVMLCVMVLVLICSAPLGENMSNLTSEERHARLRQIYIEKERRQRLGSRMGLSPLEEEANDRLMAIRQVDEEFYNLWRNYHSQPPPFLKHLNIIDTNLYAALKSMPKGGLLHVHDSGMLRMEILIDLIYRDNLWVCVNLEQDFEDFRFSRYFPHIPPAEDYQCNWMLMSNFFQLESRLEFENRLRKILTVRPEGYKSSSELVRHLRRHQRIIHGLITFRPIWSEFIFTMLSDFYADGVHYVELRSSLPNMYDLDGNNFTILETAEALVSVSNIFKNSFKDFIGIKLIYAPSRNLNDSRMDEYLENARLLKLHFPNFFAGFDLNTFGDECNLPLLENVTQLLRIGKNIDFYFHAGESRCPDSSRPDANLLEALLLQSKRIGNAVNLPFHPEIMKVMKRLSIAVEICPLSNHYLQYFNDFRQHPAAYLIAAGFPIVIGSDYPCFWNSAPLTDDFYVAFVGVISGWGDLRLLKQFALNSFLFSSLSETEKNMAVSKWQCSWNRWVRNLVNSSGY
Protein: G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) (P97711)
Organism: Rattus norvegicus (Rat)
Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro) (By similarity).
Subcellular location: Membrane; Lipid-anchor.
Interaction partners:
- ARF GTPase-activating protein GIT1
- Beta-arrestin-2
- Mu-type opioid receptor
- Beta-arrestin-1
- ARF GTPase-activating protein GIT2
- C-X-C chemokine receptor type 1
- NADH-ubiquinone oxidoreductase chain 1
- C-X-C chemokine receptor type 2
- C-X-C chemokine receptor type 4
- Beta-2 adrenergic receptor
Sequence:
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCTAFLDGVAEYEVTPDEKRKACGCRLMQNFLSHTGPDLIPEVPRQLVSNCAQRLEQGPCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLTVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVAEEYTDRFSPQARSLCSQLPNKDPAERLGCRGGGAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTDQDFYQKFATGSVSIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPTAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q9VG80)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Palmitoyltransferase
Sequence:
MSPEISGFRRFLHWGPITALSIIKCITLTTLYMNSMWWPPNKSFAGFAHQALFLLLSTLATFNYVMATLTGPGLMPKQWHPKDPKDAQFLQYCKKCEGYKAPRSHHCRKCDRCVKKMDHHCPWINHCVGWANHAYFTYFLLFSILGSLQGTVVLCCSFWRGIYRYYYLTHGLAHLASVQFTLLSIIMCILGMGLAIGVVIGLSMLLFIQLKTIVNNQTGIEIWIVEKAIYRRYRNADCDDEFLYPYDLGWRANLRLVFNDECQKRGDGIEWPVVEGCDQYTLTREQLAQKEEKRARTRTFKCTRPVTGRWLPIFSQGWRVCVAAPCSDEPRISLRPNDMIKVTRFRNHWLFGERVLSEQELAGVKKRQRKGPIRGWFPRRSAVEVIEAVHEGSGDGNSETPAPAAQNGNAHSHLKQQQRNGHAKKYM
Protein: 4F2 cell-surface antigen heavy chain (H0YFS2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XSQNAEMIETGSDCVTQAGLQLLASSDPPALASKNAEVTETGFHHVSQADIEFLTSIDPTASASGSAGITGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTD
Protein: Glutathione S-transferase U14 (AtGSTU14) (EC 2.5.1.18) (GST class-tau member 14) (Glutathione S-transferase 13) (Q9FUT1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Glutathione S-transferase DHAR1, mitochondrial
- Adenine nucleotide alpha hydrolases-like superfamily protein
- Glutathione S-transferase DHAR2
- Glutathione S-transferase DHAR3, chloroplastic
- Glutathione synthetase, chloroplastic
Sequence:
MAQNDTVKLIGCSDDPFSIRPRVALHLKSIKYEYLEEPDDDLGEKSQLLLKSNPIHKKTPVLIHGDLAICESLNIVQYLDEAWPSDPSILPSNAYDRASARFWAQYIDDKCFEAANALTGANNDEERIAATGKLTECLAILEETFQKSSKGLGFFGGETIGYLDIACAALLGPISVIEMFSADKFVREETTPGLIQWAVRFRAHEAVRPYMPTVEEVTELVKQRIEEGFKRNFKSNVSTSEYE
Protein: T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28) (P10747)
Organism: Homo sapiens (Human)
Function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:35397202}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell surface {ECO:0000269|PubMed:15067037}.
Interaction partners:
- ICOS ligand
- T-lymphocyte activation antigen CD80
- Growth factor receptor-bound protein 2
- T-lymphocyte activation antigen CD86
- Tyrosine-protein kinase Lck
- CD40 ligand
- CD276 antigen
- Tumor necrosis factor receptor superfamily member 5
- Ig-like domain-containing protein
- Programmed cell death 1 ligand 1
Sequence:
MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS
Protein: Crossover junction endonuclease MUS81 (EC 3.1.22.-) (B3KX63)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369042}.
Interaction partners:
Sequence:
MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRHRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSAPPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT
Protein: Antitoxin VapB3 (P9WJ59)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC3.
Interaction partners:
- Ribonuclease VapC3
Sequence:
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAIDAARDEFEA
Protein: Mechanosensitive ion channel protein 9 (Mechanosensitive channel of small conductance-like 9) (MscS-Like protein 9) (AtMSL9) (Q84M97)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18485707}; Multi-pass membrane protein {ECO:0000269|PubMed:18485707}.
Interaction partners:
- Protein MID1-COMPLEMENTING ACTIVITY 1
- Protein MID1-COMPLEMENTING ACTIVITY 2
- Calcium-binding EF-hand family protein
- Mechanosensitive ion channel protein 2, chloroplastic
- Mechanosensitive ion channel protein 3, chloroplastic
- Mechanosensitive ion channel protein 1, mitochondrial
- Pathogenesis-related thaumatin superfamily protein
- Hyperosmolality-gated Ca2+ permeable channel 1.1
Sequence:
MAERRVSNGEEVVINVSDKEDSKDPRASPSFNPLASPDSDAGIEKSKPVPPISIPTPEIYKFSGSVHKPPKIPSPEGLVRRKSLSRSIYSKPKSRFGEQQSFRYDSTREENGGRSLREQFGAGSFARGSFDRASPNNKSNRSVASAALSKVAEEEPDENEEIYKKVKLHRVKRSGMKPLAFLELVVFMAILGALIVSLTIDVVNKHTIWGLEFWKWCVLVMVTLSGMLVTNWFMHFVVFIIEKNYLLRKKVLYFVHGLKKNVQVFIWFSLVLIAWICLFDGDVKRTRKTKRFLDFITWTIVSLLVGSILFLVKTFALKVLASKFNVRNFFERIQESVFHQYVLQTLSGPPLIEEAENVGRVPSTGHLSFTRTKDGKVKDKKVIDMGKVHRMKQEKVSAWTMRVLIEAVGTSGISTISSTLDEVNNKKERTDKEITNEMEAVAAAYDVFNNVAKPNHNYIEEDDLLRFMIKEEVDLVLPLIEDADTGKITRKTFTEWVVNVYTSRKTIGHSLNDTKTAVKQLDKLITGILTVITFIVWMVLLDIASTKLLLVFSSQFLGLAFMIGSTCKNIFESFMFVFVMHPYDVGDRCVVDGVMLLVEEIDLLTTVFLKIDNEKVFYPNSVLISKPISNFYRSPDMGDYVDFGIAFSTPAEKIGCLKGKIGEYLVANSQHWYPEAQVMVRAIENMNKLVLNILVQHTINFQVYVEKSLRRTALIIAIKRILEDLEIDYTLLPQDVNLTGHK
Protein: Putative nicotinamide mononucleotide adenylyltransferase (NMN adenylyltransferase) (NMNAT) (EC 2.7.7.1) (NMN-specific adenylyltransferase) (Protein POF1 homolog) (Q9P7T7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Involved in the salvage pathway for NAD(+) biosynthesis via NMN.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- IMP-specific 5'-nucleotidase 1
- Putative glutamine-dependent NAD
- Uncharacterized protein C24B11.05
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- Probable nicotinate phosphoribosyltransferase
- Uncharacterized kinase C24B10.02c
- NAD-capped RNA hydrolase
- NAD-dependent protein deacetylase hst4
- Uncharacterized kinase C3H5.11
- Nicotinamide riboside kinase
Sequence:
MDQAKKYANLLDSFRSSTEDILLLERLEVSDKPIYVLDSSFNPPHFAHLGMCLSIPKGSQLLLLLSITNADKPVAPAAFNERILMMEKLKTLIHNCTVSVAICKHALFVDKCRSISNKLGPREQVYLVGFDTLIRILDCKYYKEKAMQQVLQPFFSCSQILCFSREVDGTTTDDQAQYLEKIKKSLLPNIPSQWSEKIKLTKLKGNVGFGVSSTRARQAIISGDEETQRKIIPQEILNVIKVIQPYRHR
Protein: High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma) (P20491)
Organism: Mus musculus (Mouse)
Function: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (Probable). May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- C-type lectin domain family 4 member E
- C-type lectin domain family 6 member A
- Platelet glycoprotein VI
- Natural cytotoxicity triggering receptor 1
- Tyrosine-protein kinase SYK
- TYRO protein tyrosine kinase-binding protein
- High affinity immunoglobulin epsilon receptor subunit alpha
- Low affinity immunoglobulin gamma Fc region receptor III
- Antigen presenting cell lectin-like receptor A2
- Osteoclast-associated immunoglobulin-like receptor
Sequence:
MISAVILFLLLLVEQAAALGEPQLCYILDAVLFLYGIVLTLLYCRLKIQVRKAAIASREKADAVYTGLNTRSQETYETLKHEKPPQ
Protein: Actinin, alpha 2 (Q2YDR5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MMNQIELSVPYDNGYEIDEYMMQEDEWDRDLLLDPAWEKQQRKTFTAWCNSRLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDFITSKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHVSWKDGLALCALIHRHRPDLIDYAKLNKDDPLGNLNLAFDIAEKHLDIPKMLDAEDILSTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLGVNQENEKLMEDYERLASELLEWIRRTIPWLENRAAEKTMVEMQRKLEDFRDYRRMHKPPKVQEKCQLEISFNTLQTKLRISNRPAFMPSEGKMVSDIASAWQGLEQAEKGYEEWLLTEIRRLERVEHLAEKFRQKASNHESWATGKEEMLTRKDYESASLMEVRALLRKHEAFESDLSAHQDRVEQIAAIAQELNELDYHDVASVNQRCQSICDLWDHLGTLTQRRREALERTEKLLETVDQLFLEYAKRSAPFNNWMEGAMEDLQDMFIVHTIEEVQTLIAAHEQFKATLSEADAERQAILGIQQEVLKIFQSYGIRGDLTNPYSTITAEEIAIKWDKVKKLVPQRDSALQEELARQHANERLRRQFAAQANLIGPWIQTRMEEIGHCSMAMGGTLEDQMTQLKQYEHVIVSYKSNIDRLEGDHQLIQESLIFDNKHTNYTMEHVRVGWELLLTTIARTINEIETQILTRDAKGISQEQMHEFRSSFNHFDRKENGGMDSDDFRACLISMGYDLGEVEFARIMMLVDPNASGNVSFQSFIDFMTRETADTDTAEQVIASFKILAADKPYILSDELRRELPPDQAEYCISRMPPYCGPGALPGALDYTAFSTALYGESDL
Protein: Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96) (P0C7A1)
Organism: Gallus gallus (Chicken)
Function: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:12114544}.
Interaction partners:
- MYC target 1
- Basigin
Sequence:
MQSQSVMLELREQDEVWVRLYKGERENAVFSDEYDTYITFSGHLINFQPAAEPLGTTVLHAAVDTRPQPARYFDTGTTEPVSFFLSGLEELLAWHPSSDDEFNVCAVPLAQRQPPLHSRRPRTLLCHDMRGGYLEDRFIQGSATRNPYVFYHWRYVDIFVYFSHHTVTIPPVCWTNAAHRNGVPVLGTFITEWADGEKLCEAFLAGGEDAYRAVSHQLARIAQHYRFDGWLINIENALSAAAVGNLSPFLRHLTAEVHGAVPGGLVIWYDSILESGTLRWQNELNQQNRVFFDACDGLFVNYNWKEEHLERTRELAGQRHADVYIGVDVFARGDVVGGGFDTNKSLSLIRKHGLSAAIFAPGWVYKHLGEENFLLNEDKFWGLLEDYLPTHSICTLPLATSFSVGMGTGMFLAGKEEEAGPWYNLSAQEIQPLYPERRGWLSTSCCLQDAWCGGSSLRVQGTIPPGEERVAIRLSLWVDLGSSGFSLSICGTLASGPHRDDFTVALELTTWHSSRCHDGTVTVLPSEDEPHGRHHPHLLPAPPPALSRMLAACSHGAQGWTSRCYEQELRGCSLRDLSLLVSRQQASPQETSFSCLLGELRVLDAGSMAASPPQVQSLTASQLWWQDGPSAEQLSLSLTLRWAFPPGRAACFRVLSQGARCHRAQPAQPQLLGLAHGCQYRAVGLAVPRPAPGQSCQLELLVEPVLPSELPVGPERWGRLLLVYSEPA
Protein: Kunitz-type protease inhibitor 1b precursor (Spint1b protein) (A9JR82)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MGSWCFLLVSLIFICGVYGGETQSSEQNQQCVETFHHPGRENFVLHTEESIEAGAVFLANPSVAHEDACMAACCKDARCNLALVENQASDNNCFLFNCLYKHRFVCKFTPKQGFTNYILSSVYEKYLSGRKSEGKDSPPIANAGRDVVVQPNEDVLLNGNESWDDKEIVNYEWSLTRGNKSVHMEKTNFRDQIRVSNLIPGVYEFKLTVTDSADQSDSAQVIVLVLTSEQSERHCLTPKKTGPCRASFIRWNYNAASRRCEQFIFGGCMENSNNYLSETECQNACENTTVRAGGVTRKVPVEDCSSPCGVDSFKCSSGCCVKKEFECDGHQECSDGSDEKNCQQLNESLTRLLNIEVNKKAHCTDPPATGPCRAHFHHWYYDPLSKKCHSFTYGGCDGNRNNFETADKCMKNCSGVTDKDVFARGLLVRGEELGESQSASVALAVVLAVAILAVLAVLGYFYLKNRRKHQHQRVATSNPPVGGSEDDQQMVYSSTTAKA
Protein: Protein ERD1 homolog 1 (Q9UTD8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Dolichyl-phosphate-mannose--protein mannosyltransferase 1
- Large ribosomal subunit protein uL22B
- Large ribosomal subunit protein uL22A
Sequence:
MALIEDLNHFINYFPLVLRLFFLVVFGLYSFTLILHLLVINRVDVFSLLHTPLPVNRSQQANAPLWQLSFSLSILGTLLFVIAESLYLISGSDELAYVPVFIFGVIVFMPVHKFWFFQRKVFTRQCLRILGGSYRPDYKFPDVIFSDLLTSYSRVIADLWLAGAILIYVTDSPNNSHRKQYENEVIMSMIAAYPYAIRFRQCLIERSSADNSSDKFWSTLNSIKYFTAFPAIFLGIFAKKRFSFLWFLWNTSSAINSTYSFWWDVSMDWSLPFFKQPLSIQNWKFGVRRLFPTFTFAVVSAIDFVLRMAWVVRVLPEHQSAFFTTDFGIFIMQFLEVFRRCVWVFFRIEAEASKSLAYVNISDRSDIPTIHPD
Protein: B3 domain-containing protein At5g60140 (Q9FHB0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00326}.
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- B3 domain-containing protein REM-like 3
- Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 2
- Transmembrane protein
- PLATZ transcription factor family protein
- DUF674 family protein
- Berberine bridge enzyme-like 1
- Thioredoxin-like 1-3, chloroplastic
- At1g21000/F9H16_1
- At4g19430
Sequence:
MNTRGNYSNGFTSKFFKPYLPSESGDDLVLPISFNSCLPKSLPKTVTVRSISGNIWKLGFKKCGGEVERFVMVSGWKKIVRDENLNGGDLLSFEFDGSHFFNFSIFDHETTCKRLKRSSEQSKDIIKVGSDCEEESQASDDVIVLNSDDSDDSDNDYSVEDDNVAEDDDGLEDEVDVEAEDGYDAKDSDGLEDEDDDEAEDGYDAKDDDGLEDEDDLEDEDDERRYLDDHENPYFTMTLNPKKKSQLHIPAHVIRDYDLTFPERITVVDEMGALEKAIKIQKNGCIFVKGFGSFIRRNKMKMTDKMICELKRTGGNLVHTIKVKIISG
Protein: Nuclear transcription factor Y subunit A-6 (AtNF-YA-6) (Q9LVJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Nuclear transcription factor Y subunit B-6
- Nuclear transcription factor Y subunit B-2
- Nuclear transcription factor Y subunit C-9
- Nuclear transcription factor Y subunit C-3
- Nuclear transcription factor Y subunit B-10
- Nuclear transcription factor Y subunit B-3
- Nuclear transcription factor Y subunit B-1
- Nuclear transcription factor Y subunit C-1
- Nuclear transcription factor Y subunit C-4
- Nuclear transcription factor Y subunit B-9
Sequence:
MQEFHSSKDSLPCPATSWDNSVFTNSNVQGSSSLTDNNTLSLTMEMKQTGFQMQHYDSSSTQSTGGESYSEVASLSEPTNRYGHNIVVTHLSGYKENPENPIGSHSISKVSQDSVVLPIEAASWPLHGNVTPHFNGFLSFPYASQHTVQHPQIRGLVPSRMPLPHNIPENEPIFVNAKQYQAILRRRERRAKLEAQNKLIKVRKPYLHESRHLHALKRVRGSGGRFLNTKKHQESNSSLSPPFLIPPHVFKNSPGKFRQMDISRGGVVSSVSTTSCSDITGNNNDMFQQNPQFRFSGYPSNHHVSVLM
Protein: Otolin-1 (P83371)
Organism: Oncorhynchus keta (Chum salmon) (Salmo keta)
Function: Collagen-like protein, which provides an organic scaffold for otoliths onto the sensory epithelium of the inner ear. Acts as a scaffold for biomineralization by sequestering calcium (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q4ZJM7}. Note=Localized in both the surrounding otoconial matrix and otoconia. {ECO:0000250|UniProtKB:Q4ZJM7}.
Interaction partners:
Sequence:
MPSLRLLAILTTLLAVVLIATQSSATRTTRRPKPQNTKKPPRGGGTGGGGGGGDQPARLGFRQTTTTMAPSSSLGTDETTEDTMTDAYSLSPTDSTTYAGDAYPTEFHTDSMALPGAGMGNYTLDYSHCYLNVCECCPPEKGRGPPGERGPPGPGAERGLPGVPGEKGDVGLMGPPGLDGMPGATGLEGDKGDKGDQGDTGMPGAPGILGKEGPKGDLGPKGEKGETGLPGLKGDLGERGKPGWNGTQGEKGDLGKIGPAGPSGLTGPMGQNGQKGEMGECPTGEKGEKGEAGLPGPPGPRGLVGTPGVNGTNGLPGPVGLRGQLGSPGGKGEAGGRGPPGLRGMPGPKGEKGPKGPRGVRGPKGPQGETAEQIRSAFSVGLFPSKSFPPPGLPVKFDKILYNEEEHWDPMLSKFNCTHPGVYVFSYHITVRNRPLRAALVINGVKKLRTRDSLYGQDIDQASNLALLRLASGDQVWLETLRDWNGVYSSSEDDSTFTGFLLYADPKA
Protein: Oxyopinin-4a (Oxt-4a) (F8J4S0)
Organism: Oxyopes takobius (Lynx spider) (Oxyopes foliiformis)
Function: Disrupts cell membranes through the formation of pores (Probable). Has antibacterial activity against Gram-positive bacteria S.aureus (MIC=10 uM) and B.subtilis (MIC=0.5 uM) as well as Gram-negative bacteria P.fluorescens (MIC=1 uM) and E.coli (MIC=0.5 uM). Has hemolytic activity against human erythrocytes (EC(50)=7 uM).
Subcellular location: Secreted {ECO:0000269|PubMed:21933345, ECO:0000303|PubMed:21933345}. Target cell membrane {ECO:0000305|PubMed:21933345}. Note=Probably forms a transmembrane alpha-helix in the target cell membrane. {ECO:0000269|PubMed:21933345, ECO:0000303|PubMed:21933345}.
Interaction partners:
Sequence:
MKISQVFIFVFLLMISVAWANEAYEEESNYLSERFDADVEEITPEFRGIRCPKSWKCKAFKQRVLKRLLAMLRQHAF
Protein: Muscarinic acetylcholine receptor (A0A5F7ZKY2)
Organism: Macaca mulatta (Rhesus macaque)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU361191}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361191}. Postsynaptic cell membrane {ECO:0000256|RuleBase:RU361191}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361191}.
Interaction partners:
- G protein subunit beta 4
- G protein subunit beta 1/G
- Guanine nucleotide-binding protein subunit gamma
- G protein subunit beta 2/G
- Guanine nucleotide-binding protein subunit beta-5
- G protein subunit beta 3/G
- Guanine nucleotide-binding protein G
- G protein subunit alpha i3 subunit alpha)
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MFVNFILFPCRFKCLLATWLLIREHKMNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVKDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Protein: Ankyrin 3 (H0Y3A4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
PKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGYPSLQVELETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDASLEDSKLEDSVPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS