wanglab/gogpt-training-data huggingface dataset:
Protein: Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31) (Q08481)
Organism: Mus musculus (Mouse)
Function: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity). Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity). Modulates bradykinin receptor BDKRB2 activation (By similarity). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity). Induces susceptibility to atherosclerosis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P16284}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16284}. Membrane raft {ECO:0000250|UniProtKB:P16284}. Cell junction {ECO:0000250|UniProtKB:P16284}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation. {ECO:0000250|UniProtKB:P16284}.
Interaction partners:
- Cadherin-5
- Vascular endothelial growth factor receptor 2
- Tyrosine-protein phosphatase non-receptor type 11
- Catenin beta-1
- CD177 antigen
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- Vascular endothelial growth factor receptor 3
- Tyrosine-protein phosphatase non-receptor type 6
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
- E-selectin
Sequence:
MLLALGLTLVLYASLQAEENSFTINSIHMESLPSWEVMNGQQLTLECLVDISTTSKSRSQHRVLFYKDDAMVYNVTSREHTESYVIPQARVFHSGKYKCTVMLNNKEKTTIEYEVKVHGVSKPKVTLDKKEVTEGGVVTVNCSLQEEKPPIFFKIEKLEVGTKFVKRRIDKTSNENFVLMEFPIEAQDHVLVFRCQAGILSGFKLQESEPIRSEYVTVQESFSTPKFEIKPPGMIIEGDQLHIRCIVQVTHLVQEFTEIIIQKDKAIVATSKQSSEAVYSVMAMVEYSGHYTCKVESNRISKASSIMVNITELFPKPKLEFSSSRLDQGELLDLSCSVSGTPVANFTIQKEETVLSQYQNFSKIAEESDSGEYSCTAGIGKVVKRSGLVPIQVCEMLSKPSIFHDAKSEIIKGHAIGISCQSENGTAPITYHLMKAKSDFQTLEVTSNDPATFTDKPTRDMEYQCRADNCHSHPAVFSEILRVRVIAPVDEVVISILSSNEVQSGSEMVLRCSVKEGTSPITFQFYKEKEDRPFHQAVVNDTQAFWHNKQASKKQEGQYYCTASNRASSMRTSPRSSTLAVRVFLAPWKKGLIAVVVIGVVIATLIVAAKCYFLRKAKAKQKPVEMSRPAAPLLNSNSEKISEPSVEANSHYGYDDVSGNDAVKPINQNKDPQNMDVEYTEVEVSSLEPHQALGTRATETVYSEIRKVDPNLMENRYSRTEGSLNGT
Protein: YTH domain-containing family protein (B4DPX9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFYLDLTLFHRAEETGEESFSVQNGSIHQKDAVNDDDFEPYLSSQTNQSNSYPPMSDPYMPSYYAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQPGALGNTPPFLGQHGFNFFPGNADFSTWGTSGSQGQSTQSSAYSSSYGYPPSSLGRAITDGQAGFGNDTLSKVPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMTSIATNSVPPVSSAAPKPTSWAAIARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNIGTWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGPQPQAQPHQVQPQQQQLQNRWVAPRNRGAGFNQNNGAGSENFGLGVVPVSASPSSVEVHPVLEKLRAINNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEAMRRERNRNKQ
Protein: Rho guanine nucleotide exchange factor 16 (Ephexin-4) (Q5VV41)
Organism: Homo sapiens (Human)
Function: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Ephrin type-A receptor 2
- Protein scribble homolog
- Rho-related GTP-binding protein RhoG
Sequence:
MAQRHSDSSLEEKLLGHRFHSELRLDAGGNPASGLPMVRGSPRVRDDAAFQPQVPAPPQPRPPGHEEPWPIVLSTESPAALKLGTQQLIPKSLAVASKAKTPARHQSFGAAVLSREAARRDPKLLPAPSFSLDDMDVDKDPGGMLRRNLRNQSYRAAMKGLGKPGGQGDAIQLSPKLQALAEEPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQEIQERGLNTSQESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQQEDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRMERLRVETDV
Protein: Lectin beta-1 and beta-2 chains (P04122)
Organism: Lathyrus ochrus (Cyprus-vetch) (Pisum ochrus)
Interaction partners:
Sequence:
TETTSFSITKFGPDQQNLIFQGDGYTTKERLTLTKAVRNTVGRALYSSPIHIWDSKTGNVANFVTSFTFVIDAPNSYNVADGFTFFIAPVDTKPQTGGGYLGVFNSKDYDKTSQTVAVEFDTFYNTAWDPSNGDRHIGIDVNSIKSINTKSWKLQNGKEANVVIAFNAATNVLTVSLTYPN
Protein: Palmitoyltransferase ZDHHC9 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 9) (DHHC-9) (DHHC9) (Zinc finger protein 379) (Zinc finger protein 380) (Q9Y397)
Organism: Homo sapiens (Human)
Function: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (Probable). The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16000296, ECO:0000269|PubMed:34599882}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:16000296, ECO:0000269|PubMed:27481942}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Golgin subfamily A member 7
- GTPase NRas
- mRNA decay activator protein ZFP36L2
- Serine palmitoyltransferase small subunit A
- Serine palmitoyltransferase 1
- Serine palmitoyltransferase small subunit B
- Serine palmitoyltransferase 3
- Serine palmitoyltransferase 2
- ORM1-like protein 3
- GTPase HRas
Sequence:
MSVMVVRKKVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFLILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEAAFIEMEIEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVALKSLKIGFLETLKETPGTVLEVLICFFTLWSVVGLTGFHTFLVALNQTTNEDIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGPLPPSVLDRRGILPLEESGSRPPSTQETSSSLLPQSPAPTEHLNSNEMPEDSSTPEEMPPPEPPEPPQEAAEAEK
Protein: Uncharacterized protein (Q57XR2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRMPDTRHSSSPTALRLAMLCVGVSVSVSTLLLSAAAHTPKQHNNGKVNNLKGRDAYYFYGYDNVSGKPTTGSDGITQLPDGLVRSPPLHEHSFGSPIVADWWDEGVPHFVLSGGALASEEFIRLAPAGALGARGFAFNTVPCDHKSWEVRLRFSIRTPLPIARARAMEKRRKGNEAGNGEGGEEEKEEESYQGGDGMALWYIERPIGDNNQHVPKHAKAKEDQKEEEDPSDPLDPRRVADLLHNTTESDDDDDDDDDDEGVVNETKREERHAERLKRQKEREELYSRFLKRGTSQNESDLEPRVFGLKFSDFKGFGVLIDSIGRTEGYEDGNGGEDKTGRDKKKHVKHEPKITLLLNLPGSEAEGGRPPTVNNFDPTQPDFRVSPVRLQCNYDFRQAPTPHAIMMGLNHQNIKEQKGTQRSQHKQRVEEEEEILRRTPEEPVELLVRYYDGKLRVALRRENISLRRVVFTAPPQPKARHLPQSSNYYIEHSYDETLCGELSGVKLPLMYHFGVSVSTGRRPHHSNSRKRSHSPNAPRGPLAALMANDGTAVDELAHVDVHEAMSFELRELAHDAEAMSHGKHAAMEHFDYETDQKEREEYSRGLHGGGGSVENEGNTEVKEKQ
Protein: Putrescine export system ATP-binding protein SapF (P0AAH8)
Organism: Escherichia coli (strain K12)
Function: Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Does not stimulate K(+) uptake ability of TrkH on its own, but increases K(+) uptake by 20% in the presence of SapD; has no effect of TrkG.
Subcellular location: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Putrescine export system permease protein SapC
- Putrescine export system permease protein SapB
- Putrescine export system ATP-binding protein SapD
- Probable ABC transporter periplasmic-binding protein SapA
- Dipeptide transport system permease protein DppC
- Nickel transport system permease protein NikC
- Probable D,D-dipeptide transport system permease protein DdpC
- Oligopeptide transport system permease protein OppC
- Glutathione transport system permease protein GsiD
- Glutathione transport system permease protein GsiC
Sequence:
MIETLLEVRNLSKTFRYRTGWFRRQTVEAVKPLSFTLREGQTLAIIGENGSGKSTLAKMLAGMIEPTSGELLIDDHPLHFGDYSFRSQRIRMIFQDPSTSLNPRQRISQILDFPLRLNTDLEPEQRRKQIIETMRMVGLLPDHVSYYPHMLAPGQKQRLGLARALILRPKVIIADEALASLDMSMRSQLINLMLELQEKQGISYIYVTQHIGMMKHISDQVLVMHQGEVVERGSTADVLASPLHELTKRLIAGHFGEALTADAWRKDR
Protein: Transcription attenuation protein MtrB (Trp RNA-binding attenuation protein) (TRAP) (Tryptophan RNA-binding attenuator protein) (Q9X6J6)
Organism: Geobacillus stearothermophilus (Bacillus stearothermophilus)
Function: Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan.
Interaction partners:
Sequence:
MYTNSDFVVIKALEDGVNVIGLTRGADTRFHHSEKLDKGEVLIAQFTEHTSAIKVRGKAYIQTRHGVIESEGKK
Protein: GTP-binding protein RAD (RAD1) (Ras associated with diabetes) (P55043)
Organism: Rattus norvegicus (Rat)
Function: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D (By similarity).
Subcellular location: Cell membrane {ECO:0000250}.
Interaction partners:
Sequence:
MTLNGGSGAGGSRSAGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGSLAATAAGTRTQGQRLDWPEGSSDSLSSGDSGSEDGVYKVHAAGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSITVDGEEASLMVYDIWEQDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRARRQTDVPIILVGNKSDLVRSREVSVDEGRACAEVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEDNARRQAGTRRRESLGKKAKLFLGRIVARNSRKMAFLAKSKSCHDLSVL
Protein: Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (Q8AWW3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU368074}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU368074}.
Interaction partners:
Sequence:
MKLLQKLLLLLLLAFPATLMLKGPVVSAQDATEEEEAVDEDAGDDVLAEDEDDEAEVEDDENTELTEEKEEEEEEALVGEVKASPNADTTILFVKGEDFPANNIVKFLLGFSNKGSENFVVESLDASFRYPQDFQFYIQNFTALQLGTLVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYRDDSGNVFQDAVFNQTVTITEREDGLDGETIFMYVFLSGLGLLLVIGLHQLLESRKRRRPAAKVEMGTSNHNDVDMSWIPQETLNQINKASPRRSPRKRTQKRSAGSDE
Protein: Suppressor of variegation 2-10, isoform B (A1Z7Q1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLELLAPKVQEVYAQSVQEQNATLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSETVDLTLSDSDDDMPLAKRRPPAKQAVASSTSNGSGGGQRAYTPAQQPQQSESPEQQASRQSPEKQTVSEQQLQQQQHEQPATAAVHASLLESLAAAVADQKHFQLLDLAAVAAAAAATASSGQSQNAGP
Protein: ABC transporter D family member 2 (ABC transporter ABCD.2) (Q8T8P3)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- ABC transporter D family member 3
- Putative peroxisomal biogenesis factor 19
- Peroxisome biogenesis factor 3
Sequence:
MEANFVSSALAGVQNNRSVKRSLDRLKSLFSSGQHQLNGSLGKKVFILLALGGGAFSLVKFYKAKNEGSSKQSGLIIDLKDKNSKKDKKRNVTRVDAVFFRRLAKIIRIVIPSLKSKEFLSLLYLTALLFARTMLSVSIAEIAGKNAQNLVARKWKEMRNGVLKFALVSIPASFVNASLKYETDMLALRFRKRLSEYVHKEYLEGVNFYKASHLGGADRIDNADQRVTSDIEQFCNSMSSLYTTLFKPFLDLVLFTRKLVVVMGWGSPLLMFSYFIVSGFLKKLIMPPFGRLTAKQSELEGNYRTVHQRLITNAEEIAFYDGSRKERQIINLSFGDIYNHTGYVSYLKCLVGIFDGFLVKYCASIVGYGCMVLPIYTGIRGSSGKDSTELTKDYIRNTQLMVALSQAIGQLVLLGNKVTLMAGYTSRVSELLEMIKSIKERGTSQFTIVHEDDVPNPLTNSPVNDKYDTSVDMSSWLEDWRKRSDQTRIVKRQQSNRSSASGATTVYGGGTFVEGDFIKFENVSIVSPEGKLLVENLDFQVMPNQNVMITGPNGSGKSSLFRILGELWPLHCGTVIKPRKEDILFVPQKPYLVLGTLRDQIIYPHSHDDMKKLGVTDDDLQHLLATVDPNLTIIRQWNWDDTKDWFTALSGGQKQRIAMARLFYHRPQYAILDECTSAVSDEVEGKIYETCKKLGITLFTVSHRPQLRAYHDYVLLFNGRGGWEWSKIDHDDDHLKKPLSH
Protein: Arf-GAP with dual PH domain-containing protein 2 (Centaurin-alpha-2) (Cnt-a2) (Q9NPF8)
Organism: Homo sapiens (Human)
Function: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14690521}. Cell membrane {ECO:0000269|PubMed:14690521}. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus.
Interaction partners:
- E3 ubiquitin-protein ligase RNF135
- Protein EVI2A
- Protein EVI2B
- Neurofibromin
- Cytokine receptor-like factor 3
- U3 small nucleolar RNA-associated protein 6 homolog
Sequence:
MGDRERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNFPDISRVKSVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMADGETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIKDLNATFQTEKIGHPHGLQITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQYLKMAFPELPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQGQVFLGNKEQGYEAYEDLPKGIRGNRWKAGLTIVTPERRFVLTCPSEKEQQEWLESLRGVLSSPLTPLNRLTASTESGRSSR
Protein: Ribulose bisphosphate carboxylase small subunit 3B, chloroplastic (RuBisCO small subunit 3B) (P10798)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.
Subcellular location: Plastid, chloroplast {ECO:0000255|HAMAP-Rule:MF_00860}.
Interaction partners:
- Ribulose bisphosphate carboxylase large chain
- Phosphoribulokinase, chloroplastic
- Phosphoglycolate phosphatase 1A, chloroplastic
- Phosphoglycerate kinase 1, chloroplastic
- Ribulose bisphosphate carboxylase small subunit 2B, chloroplastic
- Ribulose bisphosphate carboxylase large chain, catalytic domain-containing protein
- Phosphoglycerate kinase 3, cytosolic
- Phosphoglycerate kinase 2, chloroplastic
- D-glycerate 3-kinase, chloroplastic
- Phosphoglycolate phosphatase 2
Sequence:
MASSMLSSAAVVTSPAQATMVAPFTGLKSSAAFPVTRKTNKDITSIASNGGRVSCMKVWPPIGKKKFETLSYLPDLSDVELAKEVDYLLRNKWIPCVEFELEHGFVYREHGNTPGYYDGRYWTMWKLPLFGCTDSAQVLKEVEECKKEYPGAFIRIIGFDNTRQVQCISFIAYKPPSFTEA
Protein: Ethylene-responsive transcription factor ERF013 (Q9CAP4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ethylene-responsive transcription factor ERF116
Sequence:
MVKQELKIQVTTSSSSLSHSSSSSSSSTSALRHQSCKNKIKKYKGVRMRSWGSWVTEIRAPNQKTRIWLGSYSTAEAAARAYDAALLCLKGPKANLNFPNITTTSPFLMNIDEKTLLSPKSIQKVAAQAANSSSDHFTPPSDENDHDHDDGLDHHPSASSSAASSPPDDDHHNDDDGDLVSLMESFVDYNEHVSLMDPSLYEFGHNEIFFTNGDPFDYSPQLHSSEATMDDFYDDVDIPLWSFS
Protein: Carboxylesterase type B domain-containing protein (G5ECG6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MERIYLLLLLFLPRIRSYDVRSVTTSWGMVRGEVVSPEGDDLPPVAQYLGIPYGVAPTGQYRFNMAISAAKWTHMPKDARKVSPVCIQTDMPELSETKAFKHTSAQRFDFNHRLLPHLKKQSEDCLYMNIYVPERLEISRDNYLPVMVIVHGEEYGWGTGNAFNGTTLAAYGHIIVVTLNYRLGVFGFLGRCESSSCSGNSGISDLVSALTMLNVILPSFGGDSKSVTLAGWGSGASLVSLLMASPLTQPGRRLFRRAILLDGSALSPWAISQNPQQYFMQLAEELACAPKNRTSSFNDNVDTIVRCMQVHSSENITKAVLKIDVPTFLSGFAPIVDGQLIPNKPQVSFSTQYGSLFREIDLLVGISSNPSHHMISNEDLKVGISKEKRMRIFRSLVRNLYDFHREEILASIINEYTDWENPRDHPKSIRNGVLNALSDVLYTAPLIETLRSHSADEVRKEANTFMFAFAHETRSWSQEQPNSGIRGSLSGDIVPYIFGYPLAQGDSEERLYSGFNTDDKGISKVMMHYVSNFVKSGDPSKPNPMSKNFPMGDVFHSTAWPQFDQPNREAYLEITDRPRVKNYYRNAQVGFWNNFIPQLHKNGKETEPVGEEHHLLSDHFRKDSYFGKTRHFSSYANLPFPPPPMPPSPPPELTTKPKPSESPTTLQTTTESEKAAAGSFTGKALGGVIFIGCGFLIMNVCLLIAVRREEPLLSASHKNSTSMRPAGISPTCPRHGRAALALQNSRGNSLTAAQAPTLEEIQV
Protein: Septum site-determining protein MinD (Cell division inhibitor MinD) (Q55900)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Probable septum site-determining protein MinC
- Putative cell division topological specificity factor
- S-layer protein
- phospholipase D
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Sequence:
MNRIIVVTSGKGGVGKTTTTANLGAALARLGKKVVLIDADFGLRNLDLLLGLEQRIVYTAIDVLADECTIDKALVKDKRLPNLVLLPAAQNRSKDAINAEQMQSLVEQLKDKFDYIIIDCPAGIEAGFRNAVAPAQEAIIVTTPEMSAVRDADRVIGLLEAEDIGKISLIVNRLRPEMVQLNQMISVEDILDLLAVPLIGILPDDQKIIISTNKGEPLVMEEKLSVPGLAFQNIARRLEGQDIPFLDFMAAHNTLLNRIRRRLLGG
Protein: ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) (Transmembrane protein 32) (Q8N4V1)
Organism: Homo sapiens (Human)
Function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (By similarity). May be involved in Mg(2+) transport (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8K273}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}. Early endosome membrane {ECO:0000250|UniProtKB:Q8K273}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}.
Interaction partners:
- Endoplasmic reticulum membrane protein complex subunit 7
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 9
- ER membrane protein complex subunit 8
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 2
- Ubiquilin-2
Sequence:
MAPSLWKGLVGIGLFALAHAAFSAAQHRSYMRLTEKEDESLPIDIVLQTLLAFAVTCYGIVHIAGEFKDMDATSELKNKTFDTLRNHPSFYVFNHRGRVLFRPSDTANSSNQDALSSNTSLKLRKLESLRR
Protein: Fibroblast growth factor (FGF) (Q1XG75)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRRWTVSKSVSACWSVCVVYFLAVSVTCRGACLRVSSSASTSTSGRHARSYVHLQGDVRQRRLFSFQKFFLRIGKDGKVNGTKSEDDPYSILEITSVDVGVVAIRGLGSNLYLAISKKGELFGVRNYGTNCRLKERIEENGYNTYASAKWKNNKRQIFVSLSAHGRPLRGRKNRRKNTATHFLPMVV
Protein: Polybromo 1 (H0Y5B5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
IRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPAYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKRAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNL