wanglab/gogpt-training-data huggingface dataset:
Protein: 55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Q00013)
Organism: Homo sapiens (Human)
Function: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19144871}; Lipid-anchor {ECO:0000305|PubMed:1713685}. Cell projection, stereocilium {ECO:0000250|UniProtKB:P70290}. Note=Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with PALS1 in the retina, at the outer limiting membrane (OLM) (By similarity). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC) (By similarity). Colocalizes with NF2 in non-myelin-forming Schwann cells (PubMed:19144871). {ECO:0000250|UniProtKB:P70290, ECO:0000269|PubMed:19144871}.
Interaction partners:
- Whirlin
- Glycophorin-C
- Unconventional myosin-XV
- Protein 4.1
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Calcium/calmodulin-dependent protein kinase type II subunit delta
- Epidermal growth factor receptor kinase substrate 8
- Epidermal growth factor receptor kinase substrate 8-like protein 2
- Peripheral plasma membrane protein CASK
- Gelsolin
Sequence:
MTLKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESAGLIPSPELQEWRVASMAQSAPSEAPSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY
Protein: Arf-GAP domain and FG repeat-containing protein 2 (HIV-1 Rev-binding protein-like protein) (Rev/Rex activation domain-binding protein related) (RAB-R) (O95081)
Organism: Homo sapiens (Human)
Interaction partners:
- Epidermal growth factor receptor substrate 15-like 1
- Epidermal growth factor receptor substrate 15
Sequence:
MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDITVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTSLVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLGDPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMAPAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTTNPFL
Protein: Uncharacterized protein, isoform K (M9PC24)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAALQRKLVHKQFNSPMGLYSQENVKATLNRELKAFGGEGIEVDDQITKPLNLANSAVLRAVEEEEQQAKCGYKRVAWPPASEERIIREFTPQPQTQSPAPGAGGYYPQAHAPTAAAAAPPQGPIYNNVQPRTTQTPQNAYPSAPQTTSTAYPTNQYPDSYSHQEQQQQQQQQQPVQYTQAQFGRQRSREPVQVSAPSPAPATDPSGYPYQANYQSNYPQEPLQAVNNVGGGWKHIGAPQPKSRSEFTAGNGAYPPFQGSYQQQQQQPQQQQYGAPSYDGQQPGAQWQQQQQQQQVPQQQYQPQSQAQAPYQPPQWNQPQQQQQQPSYQASPYQQQQQQQPSYYPQQNGGSTYAQPPYNSYSQPQLPYSQDQTDLQQQQQQQQQQYPGAYAGQDSYRGASPGIITLRKEAPVSQKPAPVYTSQPAAVSYQGGSKLRGDLKWPPPEYKEAAARENEERRQLALGPVCRPRRVNRDYTPFFAKHQLNNGYPSYKVPPGTQHIFG
Protein: Guanine nucleotide-binding protein alpha-2 subunit (G alpha-2) (P16051)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta
- Latrophilin receptor-like protein A
- Cyclic AMP receptor 1
- Cyclic AMP receptor 3
- Cyclic AMP receptor 2
- Cyclic AMP receptor 4
- Guanine nucleotide-binding protein subunit gamma
- Adenylate cyclase, aggregation specific
- RGS domain-containing protein
Sequence:
MGICASSMEGEKTNTDINLSIEKERKKKHNEVKLLLLGAGESGKSTISKQMKIIHQSGYSNEERKEFKPIITRNILDNMRVLLDGMGRLGMTIDPSNSDAAVMIKELTSLQASIVTDCWGELNEDQGKKIKALWTDPGVKQAMRRANEFSTLPDSAPYFFDSIDRMTSPVYIPTDQDILHTRVMTRGVHETNFEIGKIKFRLVDVGGQRSERKKWLSCFDDVTAVVFCVALSEYDLLLYEDNSTNRMLESLRVFSDVCNSWFVNTPIILFLNKSDLFREKIKHVDLSETFPEYKGGRDYERASNYIKERFWQINKTEQKAIYSHITCATDTNNIRVVFEAVKDIIFTQCVMKAGLYS
Protein: Dynamin-related protein 12A (Phragmoplastin) (Soybean dynamin-like protein 12A) (SDL12A) (Q39821)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Microtubule-associated force-producing protein that is targeted to the forming cell plate during cytokinesis. May be involved in attaching Golgi-derived vesicles to microtubules which direct vesicles to the forming cell plate during cytokinesis. Possesses intrinsic GTPase activity in vitro.
Subcellular location: Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:9061948}. Note=Localized in the forming cell plate during cytokinesis (at protein level). {ECO:0000269|PubMed:9061948}.
Interaction partners:
- Secretory carrier-associated membrane protein
- Secretory carrier-associated membrane protein
- Secretory carrier-associated membrane protein
- Secretory carrier-associated membrane protein
- Secretory carrier-associated membrane protein
- Secretory carrier-associated membrane protein
- Secretory carrier-associated membrane protein
- Secretory carrier-associated membrane protein
- Secretory carrier-associated membrane protein
- Secretory carrier-associated membrane protein
Sequence:
MENLISLVNKIQRACTALGDHGENSALPTLWDSLPAIAVVGGQSSGKSSVLESVVGKDFLPRGSGIVTRRPLVLQLHKIDEGSREYAEFLHLPRKRFTDFVAVRKEIQDETDRETGRTKQISSVPIHLSIYSPNVVNLTLIDLPGLTKVAVEGQPDSIVKDIEDMVRSYIEKPNCIILAISPANQDLATSDAIKISREVDPTGDRTIGVLTKIDLMDKGTDAVDILEGRAYRLKFPWIGVVNRSQQDINKNVDMIAARRREREYFNSTPEYKHLANRMGSEHLAKMLSKHLETVIKSKIPGIQSLINKTIAELEAELTRLGKPVAADAGGKLYAIMEICRSFDQIFKDHLDGVRPGGDKIYNVFDNQLPAALKRLQFDKQLSMENIRKLITEADGYQPHLIAPEQGYRRLIESSLITIRGPAESAVDAVHSLLKDLVHKAMSETLDLKQYPGLRVEVGAASVDSLERMRDESKRATLQLVDMECGYLTVDFFRKLPQDVDKGGNPTHSICDRYNDSYLRRIGTTILSYVNMVCATLRHSIPKSIVYCQVREAKRSLLDHFFTELGKMEIKRLSSLLNEDPAIMERRSALAKRLELYRSAQAEIDAVAWSK
Protein: UPP (cDNA FLJ77390) (A8KAF9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATELQCPDSMPCHNQQVNSASTPSPEQLRPGDLILDHAGGNRASRAKVILLTGYAHSSLPAELDSGACGGSSLNSEGNSGSGDSSSYDAPAGNSFLEDCELSRQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYKECMVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD
Protein: Lariat debranching enzyme (EC 3.1.4.-) (Q9UK59)
Organism: Homo sapiens (Human)
Function: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
- CWF19-like protein 1
Sequence:
MRVAVAGCCHGELDKIYETLALAERRGPGPVDLLLCCGDFQAVRNEADLRCMAVPPKYRHMQTFYRYYSGEKKAPVLTLFIGGNHEASNHLQELPYGGWVAPNIYYLGLAGVVKYRGVRIGGISGIFKSHDYRKGHFECPPYNSSTIRSIYHVRNIEVYKLKQLKQPIDIFLSHDWPRSIYHYGNKKQLLKTKSFFRQEVENNTLGSPAASELLEHLKPTYWFSAHLHVKFAALMQHQAKDKGQTARATKFLALDKCLPHRDFLQILEIEHDPSAPDYLEYDIEWLTILRATDDLINVTGRLWNMPENNGLHARWDYSATEEGMKEVLEKLNHDLKVPCNFSVTAACYDPSKPQTQMQLIHRINPQTTEFCAQLGIIDINVRLQKSKEEHHVCGEYEEQDDVESNDSGEDQSEYNTDTSALSSINPDEIMLDEEEDEDSIVSAHSGMNTPSVEPSDQASEFSASFSDVRILPGSMIVSSDDTVDSTIDREGKPGGTVESGNGEDLTKVPLKRLSDEHEPEQRKKIKRRNQAIYAAVDDDDDDAA
Protein: Vacuolar-sorting protein SNF7 (Vacuolar protein-sorting-associated protein 32) (Q5ABD0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
Subcellular location: Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- pH-response regulator protein palA/RIM20
- ESCRT-III subunit protein
- ESCRT-III subunit protein
- ESCRT-III subunit protein
- Vacuolar protein sorting-associated protein 4
- Vacuolar protein-sorting protein BRO1
- Ubiquitin-binding ESCRT-I subunit protein
- Vacuolar-sorting protein SNF8
- Uncharacterized protein
- Vacuolar protein sorting-associated protein 28
Sequence:
MWGYFFGGNSQQKKDLPKKAIVELREHIQTLNKKKNHLQQQMDDQDQLARKYVSSKQTTLAKSALKRKKGYESNLLKVENQIETLETQLISIEGANLNLETMKAMKQGAKAMKQIHGEYDVDKVEDTMDEIREQVELADEISEAISRPVGNEFVDEDELDEELKELEAEAKEQEQEHRVPAQKAKPQPVSREEELPQFPSVNKKAPVVEEDEDEEALKALQAEMGL
Protein: Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (dMED21) (dSRB7) (dTRAP19) (Q9W5P1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 20
Sequence:
MADRLTQLQDTVNQQAEHFCNAIGVIQQTSLPSKFVNFERIGPQTPIPCPPQEDYAQLFAQLIARCAKDIDTLIESLPNEDSSIELQNSSLKRLEIENQGTARDLEEVVQKGELLLEKMQYSLECIAQAQLDMQITLKHDLQ
Protein: Pre-mRNA-splicing factor PRP21 (P32524)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly.
Subcellular location: Nucleus.
Interaction partners:
- Cold sensitive U2 snRNA suppressor 1
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor SYF1
- Protein HSH49
- Pre-mRNA-splicing factor CLF1
- RDS3 complex subunit 10
- Pre-mRNA-processing factor 19
- Pre-mRNA-processing ATP-dependent RNA helicase PRP5
- Pre-mRNA-splicing factor RDS3
- Protein NAM8
Sequence:
MEPEDTQLKEDIKTTVNYIKQHGVEFENKLLEDERFSFIKKDDPLHEYYTKLMNEPTDTVSGEDNDRKSEREIARPPDFLFSQYDTGISRRDMEVIKLTARYYAKDKSIVEQMISKDGEARLNFMNSSHPLHKTFTDFVAQYKRVYSFTGQEIKKSKRTILDNCFERTQYWEFEKDKDREHDKLVELCKIQFAAIPWDKFTQVAKFSIPEDTEIFEGSLDLEQMRLRRVQTGIKLFDSIKPTNEEEKIVSDQGKQKGGDSKGKKRKIRAVGETRLKKSKK
Protein: Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain] (O60235)
Organism: Homo sapiens (Human)
Function: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.
Subcellular location: Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted.; SUBCELLULAR LOCATION: [Transmembrane protease serine 11D catalytic chain]: Secreted. Note=Activated by cleavage and secreted.
Interaction partners:
- Angiotensin-converting enzyme 2
Sequence:
MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
Protein: Beta-glucosidase 10 (AtBGLU10) (EC 3.2.1.21) (Q93ZI4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serine carboxypeptidase-like 10
- Coumaroyl-CoA:anthocyanidin 3-O-glucoside-6''-O-coumaroyltransferase 2
- Beta-glucosidase 9
- Malonyl-CoA:anthocyanidin 5-O-glucoside-6''-O-malonyltransferase
- Beta-glucosidase 22
Sequence:
MKLYSLLSVFLVILLATSDSDAFTRNNFPKDFLFGAATSAYQWEGAVAEDGRTPSVWDTFSHTYNRGNLGNGDITSDGYHKYKEDVKLMAEMGLESFRFSISWSRLIPNGRGLINPKGLLFYKNLIKELISHGIEPHVTLYHYDLPQSLEDEYGGWINRKIIEDFTAYADVCFREFGEDVKLWTTINEATIFAIGSYDQGISPPGHCSPNKFINCTSGNSSTEPYLAGHNILLAHASASKLYKLKYKSTQKGSIGLSIFAFGLSPYTNSKDDEIATQRAKAFFYGWMLKPLVFGDYPDEMKRTVGSRLPVFSEEESEQLKGSSDFIGIIHYTTFYVTNKPSPSIFPSMNEGFFKDMGVYMISAANSSFLLWEATPWGLEGILEYIKQSYNNPPIYILENGMPMGRDSTLQDTQRIEFIQAYIGAMLNAIKNGSDTRGYFVWSMIDLYELLSGYTTSFGMYYVNFSDPGRKRTPKLSASWYTGFLNGTIDVATQDTIQLQSNISGSSSL
Protein: Ras guanine nucleotide exchange factor B (RasGEF domain-containing protein B) (Q8IS21)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Promotes the exchange of Ras-bound GDP by GTP (By similarity). Involved in phagocytosis, fluid-phase endocytosis, regulation of macropinocytosis and control of cell movement.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11102804}.
Interaction partners:
- Ras-like protein rasS
Sequence:
MVVILWGWNENRFNTLDQVISFDFIEENKKLYLKILENEKQQKIYNISNLIGRRMDNYRDNNNNNGNGSNINNNGIIINSSMGSQYFNLNKGIIIVESDNETFLIEEIDYLGKFPILKQFIKCEEFIGISTLEIISNIEKQLSNLVNLKSNTTEQTDRKYKTNLIDFKESIIQLEKDCKNLLKQSNLINPSIKYSVVKSVKFLLKEIKFEFYHGDINIKRIELFQQLKKFLKIHFWNNPNLILNSGSNIDMTDSNDSISSEEINSPNDLNLSLSSFPSISSPSNSSYNNINTLTFSNNNNNNNNNSNNNNNNNNNNNNNNSIINSNNNNNSNNNSNISNSSNNNNNNSNNSNNISINVSKTGNNSVINSPTQSSSCYIDCDDTMSNYTDCTNTTNTNSTTTTTTTTTTYGNNLNVYNNNNNNNTNNNNNNVPYKKPALKMMKSPSFKIQLIQEVYLEIMDQCKKIQNYLYELLDTYLTDEEYINNNNNNNNKDISILFENNTSYCIAQEIFISLIKNSNDFLYQVQLIDLTDTRKKSKELSEVSNQLFYSTQQLFPSISDHLDFIEMDIFTNNNTTTTTTTTTTTTNTTTNPSNTIKSSHSSLLSSSYSSSKDDDIVLTINKVLSKLDTFSKEYTKLIGNNLSSNYYVDSGNNNESVSSPKCGLFLSHSLSTDSPMTYVKRNTSSGSSASTSSYTTPVSSSASLSFSSSTQTPSSAASQHHIQQILQQQQQQQQQQQQQQQQQQPQQIQSQSQQQHQQQQQQQQQQQQQQQQQQQQQQQQQQQQIQSQSQQQQQLNRKPHYSSISPTSMLVYNATGGKFGVVNQNNNSAESTPTFQLNTMDILNSLMGKEGQNSNTNNANNPNNNNNNNNNNNNNNNNNNNNNNNNENKNENKNETNKSGHNYNNSSTSTLSSSTTIGDLANVSSTNSPNSSTPNLLLPPHQFHNHNREYNHSHHHLLSSSSNNVMINNRSIGKSFSTGNFSQPQPIMPSNGIGGSGGGGLGTTLSVGNGGIVGGLQSRSSSFEENQLQYAIESFMEVYNHLTSKDKVDTSIWLEEEKEDINVYYINNTNIDDKFYRSIKYASLNQLILKLTCESNTELRFTKTFITTYRSFTTGDIFLMKLIQRYFTPNLKNIVPYQFVQKIQIPIQLRVLNVLRLWIEQYPSDFQQPPQITTQSTQPIQNSTTQPQPQPQPQQPQPQLQQSTNLQNSTIQQPSLFKMLTAFLNSTRRNGHGQYSDLILKKFKQQKQKDRLQLPIINNGQGIPKAKIFWMKYSTEFIFSQSSTDIAEQLTLLDFDSYKSIEEIELLNQAWSKPDQKTNTPNIASMVNRFNSFSSFVSWAILRENDIKQRSKMMLKMIKICYALYKLSNFNGLLAGLSGLMASGVYRLNHTKSLISKQYQKKFDFLCKFLDTKKSHKVYRDIIHSTCPPLIPYLGIYLTDLTFIEDGNQDEIKGLINFKKREMIFNTILEIQQYQQQGYTIKPKPSVLGFLCELPHMSDKKKFEDDTYEQSILLEPKNSTKLEVMNAKK
Protein: Dynein light chain roadblock (Q38D18)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR009998}.
Interaction partners:
- Cytoplasmic dynein 2 light intermediate chain 1
- Dynein light chain, putative
- Dynein light chain, putative
- Dynein light chain
- Dynein light chain
- Dynein light chain
- Dynein light chain
- Dynein light chain
- Dynein light chain
- Uncharacterized protein
Sequence:
MSEIEESFQRISQRPNVTGIIVVNNEGTPIRSTIEDTATQNQYAHLITALAAKARHCVRDLDPTNDICFLRIRSKKNEIMVAPDKDFTLIVIQRFSDV
Protein: Saccharopine dehydrogenase [NAD(+), L-lysine-forming] (SDH) (EC 1.5.1.7) (Lysine--2-oxoglutarate reductase) (Q09694)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.
Interaction partners:
- Saccharopine dehydrogenase [NADP
- Probable acetylornithine aminotransferase, mitochondrial
- L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
- Multifunctional protein ura1
- Homoaconitase, mitochondrial
- L-2-aminoadipate reductase
- Ornithine decarboxylase
- Homoisocitrate dehydrogenase
Sequence:
MVAPHLWLRAETKPLEERSALTPRTAKILADAGFQITIERSSQRAFKDKEFERLGFPMVPEGSWRHAPKDAYIIGLKELPENDNSPLKHTHIQFAHCYKNQEGWREVLSRFPAGNGLLYDLEFLQDDNGRRVAAFGYHAGFAGSAISCLVWAHQLLHPNKQFPAIRPFPNEKSLVRHVARQVRLALKKNNNQYPRILVIGALGRCGTGACDLASKIGIPFDNILRWDINETKKGGPFTEITESDIFVNCIYLSMPIPKFCTVESLNVPNRKLRVVCDVSCDTTNPNNPIPIYNVNTTFDHPTVEVKGVTTPPPLEVISIDHLPTLLPRESSEAFSEALIPSLLALKDVDNAPVWVRAKKLYETMVQKL
Protein: Putative eukaryotic translation initiation factor 4 gamma (Q1MSJ4)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MEKDHQPVISLRPGGGGGGPRPGRLFSPAFAAAASGSGDLLRSHVGGASKIGDPNFEVRERVRYTRDQLLELREIVDIPEAILRIKQEIDIELHGEDQIWGRPESDVQVQTQTQAQPHNRYGETDNRDWRARTVQPPAANEEKSWDNIREAKAAHASSGRQQEQVNRQDQLNHQFASKAQVGPTPALIKAEVPWSARRGNLSEKDRVLKTVKGILNKLTPEKFDLLKGQLMESGITTADILKDVISLIFEKAVFEPTFCPMYAQLCSDLNEKLPSFPSEEPGGKEITFKRVLLNNCQEAFEGAESLRAEIAKLTGPDQEMERRDKERIVKLRTLGNIRLIGELLKQKMVPEKIVHHIVQELLGSGPDKKACPEEENVEAICQFFNTIGKQLDENPKSRRINDTYFIQMKELTTNLQLAPRLRFMVRDVVDLRSNNWVPRREEIKAKTISEIHDEAIKTLGLRPGATGLTRNGRNAPGGPLSPGGFPMNRPGTGGMMPGMPGTPGMPGSRKMPGMPGLDNDNWEVPRSKSMPRGDSLRNQGPLLNKPSSINKPSSINSRLLPHGSGALIGKSALLGSGGPPSRPSSLMASPTHTPAQTAPSPKPVSAAPAVVPVTDKAAGSSHEMPAAVQKKTVSLLEEYFGIRILDEAQQCIEELQCPEYYSEIVKEAINLALDKGPNFIDPLVRLLEHLHTKKIFKTEDLKTGCLLYAALLEDIGIDLPLAPALFGEVVARLSLSCSLSFEVVEEILKAVEDTYFRKGIFDAVMKTMGGNSSGQAILSSHAVVIDACNKLLK
Protein: RNA binding motif protein 24, isoform CRA_a (cDNA FLJ76592) (cDNA, FLJ79505, highly similar to RNA-binding region-containing protein 1) (A8KAI7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHTTQKDTTYTKIFVGGLPYHTTDASLRKYFEVFGEIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFGVQQLHPALIQRPFGIPAHYVYPQAFVQPGVVIPHVQPTAAAASTTPYIDYTGAAYAQYSAAAAAAAAAAAYDQYPYAASPAAAGYVTAGGYGYAVQQPITAAAPGTAAAAAAAAAAAAAFGQYQPQQLQTDRMQ
Protein: Peptide tarsal-less 2A (Peptide polished rice 2) (C0HJX5)
Organism: Drosophila melanogaster (Fruit fly)
Function: One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes. Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation. Promotes the post-translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development. This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to svb for ubiquitination of its N-terminus, converting svb into a transcriptional activator. Also enhances interaction of Ubr3 with Diap1. Required for correct wing and leg formation through its regulation of several genes including those in the Notch signaling pathway. Essential for denticle formation and may have a role in the developmental timing of trichome differentiation. Essential for the development of taenidial folds in the trachea.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26383956}. Nucleus {ECO:0000269|PubMed:26383956}.
Interaction partners:
Sequence:
MAAYLDPTGQY
Protein: tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (miRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) (Q9UBP6)
Organism: Homo sapiens (Human)
Function: Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA). Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:26751069}.
Interaction partners:
- tRNA
- tRNA
- tRNA
- tRNA
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- RNA cytosine C
- SAGA-associated factor 29
- tRNA methyltransferase 10 homolog C
- Transcriptional adapter 2-alpha
- Pseudouridylate synthase TRUB1
Sequence:
MAAETRNVAGAEAPPPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQNQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPVLQAVTSQTSLPGH
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (Q7SXZ4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGDSELRDASEFIKDRLYFATLRSKPKSTANTHFFCTDDEYIYENFYADFGPLNLAMLYRYCCKLNKKLKSFTLSRKRIIHYTSYDQRKRANAAFLIGAYAVIYLKRTPEEVYRALISGTNVSYLPFRDAAFGNCTYDLTILDCLQGIRKALQHGFFDFENFDVEEYEHYERVENGDFNWIVPGKLLAFSGPHPKSKIENGYPLHAPEAYFSYFRQHNVTDVVRLNKKIYEGRRFTDAGFEHHDLFFVDGTTPSDLLTRRFLHICESAKGAVAVHCKAGLGRTGTLIGCYLMKHYRFTAPEAIAWTRICRPGSVIGPQQHFLEQKQHSMWVQGDLHRSKQKQQQLRQSRQQERNMSHLISSVDNLSIDSSILKPPSVDENEFREEDMILTQGDKLLALKGQRHPRSTTTVLSGINPAPGTISPPKTTKAPLFHPSSAEPLMRNPSSSAGNLQSINPRLAHSLGNLYDDNSLNDDDSSTPPSSFPPSPPPAPAQGPPIPSSGFSFGYTTADPRLPPSHLNFNQEANTNPNGLIATNTISANRTVRPVNRTGFGMFSGGRPGPRRGPLRTGLNGFPGRYLSRSIPSLQSEYAQY