wanglab/gogpt-training-data huggingface dataset:
Protein: Eukaryotic translation initiation factor 3 subunit B (eIF3b) (eIF-3-eta) (eIF3 p110) (F4K4D5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|HAMAP-Rule:MF_03001, ECO:0000256|PIRNR:PIRNR036424}.
Interaction partners:
Sequence:
MEVVDIDARAAKLGIDWSQVNFDSIQLPPGEDFGIESDDEAVYQDDQSEFDTGFGNIIVVDHLPVVPKEKFEKLEGVVKKIYNQLGVIKENGLWMPVDPDTKMTLGYCFIEFNTPQKGAQTRLFLMVEYFLRVSLNVWGSLQEAQNAKEKSHGYKLDKSHIFAVNMFDDFDRLMNVKEEWEPPQARPYVPGENLQKWLTDEKARDQLVIRSGPDTEVFWNDTRQKAPEPVHKRPYWTESYVQWSPLGTYLVTLHKQGAAVWGGADTFTRLMRYQHSMVKLVDFSPGEKYLVTYHSQEPSNPRDASKVEIKVFDVRTGRMMRDFKGSADEFSIGGPGGVAGASWPVFRWAGGKDDKYFAKLSKNTISVYETETFSLIDKKSMKVDNVVDICWSPTDSILSLFVPEQGGGNQPAKVALVQIPSKVELRQKNLFSVSDCKMYWQSSGEYLAVKVDRYTKTKKSTYSGFELFRIKERDIPIEVLELDNKNDKIIAFAWEPKGHRFAVIHGDQPRPDVSFYSMKTAQNTGRVSKLATLKAKQANALFWSPTGKYIILAGLKGFNGQLEFFNVDELETMATAEHFMATDIEWDPTGRYVATAVTSVHEMENGFTIWSFNGIMLYRILKDHFFQLAWRPRPPSFLTAEKEEEIAKTLKKYSKKYEAEDQDVSLLLSEQDREKRKALKEEWEKWVMQWKSLHEEEKLVRQNLRDGEVSDVEEDEYEAKEVEFEDLIDVTEEIVQES
Protein: Taste receptor type 2 member 38 (T2R38) (PTC bitter taste receptor) (Taste receptor type 2 member 61) (T2R61) (P59533)
Organism: Homo sapiens (Human)
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Taste receptor type 2 member 16
- Taste receptor type 1 member 2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Taste receptor type 1 member 3
- Taste receptor type 1 member 1
- Gamma-aminobutyric acid type B receptor subunit 2
Sequence:
MLTLTRIRTVSYEVRSTFLFISVLEFAVGFLTNAFVFLVNFWDVVKRQALSNSDCVLLCLSISRLFLHGLLFLSAIQLTHFQKLSEPLNHSYQAIIMLWMIANQANLWLAACLSLLYCSKLIRFSHTFLICLASWVSRKISQMLLGIILCSCICTVLCVWCFFSRPHFTVTTVLFMNNNTRLNWQIKDLNLFYSFLFCYLWSVPPFLLFLVSSGMLTVSLGRHMRTMKVYTRNSRDPSLEAHIKALKSLVSFFCFFVISSCAAFISVPLLILWRDKIGVMVCVGIMAACPSGHAAILISGNAKLRRAVMTILLWAQSSLKVRADHKADSRTLC
Protein: Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) (Q92754)
Organism: Homo sapiens (Human)
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Subcellular location: Nucleus {ECO:0000269|PubMed:24413532}.
Interaction partners:
- WW domain-containing oxidoreductase
- Myc proto-oncogene protein
- Cbp/p300-interacting transactivator 2
- Estrogen receptor
- BTB/POZ domain-containing protein KCTD1
- Transcription factor AP-2-alpha
- Lysine-specific demethylase 5B
- Trans-acting T-cell-specific transcription factor GATA-3
- Epidermal growth factor receptor
- Choriogonadotropin subunit beta 3
Sequence:
MLWKITDNVKYEEDCEDRHDGSSNGNPRVPHLSSAGQHLYSPAPPLSHTGVAEYQPPPYFPPPYQQLAYSQSADPYSHLGEAYAAAINPLHQPAPTGSQQQAWPGRQSQEGAGLPSHHGRPAGLLPHLSGLEAGAVSARRDAYRRSDLLLPHAHALDAAGLAENLGLHDMPHQMDEVQNVDDQHLLLHDQTVIRKGPISMTKNPLNLPCQKELVGAVMNPTEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKPVAEYLTRPHLGGRNEMAARKNMLLAAQQLCKEFTELLSQDRTPHGTSRLAPVLETNIQNCLSHFSLITHGFGSQAICAAVSALQNYIKEALIVIDKSYMNPGDQSPADSNKTLEKMEKHRK
Protein: Fe(3+)-Zn(2+) purple acid phosphatase (PAP) (EC 3.1.3.2) (Iron(III)-zinc(II) purple acid phosphatase) (P80366)
Organism: Phaseolus vulgaris (Kidney bean) (French bean)
Subcellular location: Secreted {ECO:0000303|PubMed:12054466}.
Interaction partners:
Sequence:
MGVVKGLLALALVLNVVVVSNGGKSSNFVRKTNKNRDMPLDSDVFRVPPGYNAPQQVHITQGDLVGRAMIISWVTMDEPGSSAVRYWSEKNGRKRIAKGKMSTYRFFNYSSGFIHHTTIRKLKYNTKYYYEVGLRNTTRRFSFITPPQTGLDVPYTFGLIGDLGQSFDSNTTLSHYELSPKKGQTVLFVGDLSYADRYPNHDNVRWDTWGRFTERSVAYQPWIWTAGNHEIEFAPEINETEPFKPFSYRYHVPYEASQSTSPFWYSIKRASAHIIVLSSYSAYGRGTPQYTWLKKELRKVKRSETPWLIVLMHSPLYNSYNHHFMEGEAMRTKFEAWFVKYKVDVVFAGHVHAYERSERVSNIAYKITNGLCTPVKDQSAPVYITIGDAGNYGVIDSNMIQPQPEYSAFREASFGHGMFDIKNRTHAHFSWNRNQDGVAVEADSVWFFNRHWYPVDDST
Protein: Torsin-4A (Torsin family 4 member A) (Q9NXH8)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDRGQPSLEPAAAAPRASGRCVIAPVRAVLRLRRRVCVLRKRRLLQPGGGPDVGTGAPRPGCSPRAPRADLDQPKFFTFDSPAELPSRTPRKKRRRSRLVLYPETSRKYRPRVEHRSRAQRCLLLLVAIVGFQVLNAIENLDDNAQRYDLDGLEKALQRAVFGQPAAVSRIVALMRDYLATHVHSRPLLLALHGPSGVGKSHVGRLLARHFRSVLEDSALVLQYHARHHCPEARAAQDCREELARRVADVVARAEAEEKTPLLVLDDVELMPRPLLDELHGFLQPQRSHHFHNAIYVLLSGAGGAEVTRFVLQNASRALPLRPDGFRSAEAAAAQAEEDLRASLLAVLSREHPLWQAAAIVPFLLLDKRDVVSCFRDEMAGEGFFPDQARAENLAAQLSFYRVAGREFAVTGCKQVVATVNLL
Protein: DNA-directed RNA polymerase subunit beta (Q9LU25)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MERGMNNGQSLWHSQSPKTPTTMLDRALSSRRPHSDADLSASGESGTDESKTKRPHIYLLASNFLSRIGHQWWPCLILALLFLVLLFLISVAFHSHSFVCISRFDPAARIGFFGLDGLESDFGALGVPWCRSKHGKEVEWTSKDLLKGLEEFVPIYETRPIKNNMYGMGFDHSFGLWFMARWLKPDMMIESGAFKGHSTWVLRQAMPDTPMISLTPRHPEKYLRKGPAYVDGNCTYFAGKDFVDFGSVDWKNVLRKHGITDLSRVIVFFDDHQNELKRLKQALKAGFRHLIFEDNYDTGTGDHYSLRQICDQSHIRGGGHSCFKDSDEARMRSKRKKFWEKAVDTEELCGPGETWWGVKGEMRDDFNHTNTPISYNQHFQNSRYVESILDVYWELPPVAGPSLTHQSRYDPARATPPIVADGKHRLFQRIGLGRLDKSVFNGYTQMVYLEISKPGS
Protein: Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1) (BmHen1) (H9JDT2)
Organism: Bombyx mori (Silk moth)
Function: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q568P9}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q568P9}.
Interaction partners:
- Tudor and KH domain-containing protein homolog
Sequence:
MIIAIQTLIFFRQSLLTALDRLLRPYFQKFALSLTKSSFESDDDEPDENVFAEYDDEKGVIFFPPMYVQRYAAIVDCLLDERWSGKLDKVVDLGYHDMSFIKYLKEVSGIKSILGVDLETIPLQCSSDLLSCNEYAPKRETPLQISLLQGNAADPDYRLIGCDAVIAIEMIEHMLPHDLERLVHTVFAFIKPWIVIFTTPNDFKDVITGDINICKFNEKYLHRLNCTTLQVKKFSKTTQGLMAKNKVDALVHTREVVEEIKHLTKMLNFNKSGLNQQDEKTHIWYNFNWGENAPYWNQYYKIVREYNYPFETKSDDCRILDLISDEMNRLIDLQYDDILSVDLNKLEIPLQHLMQTVQHITDDVENVRELLEWNGYEVVDDMVIYSRLAIDNVTIDSQIDDWQENESVSDVKKFN
Protein: RE74316p (Q8IGK0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MCAAQNPPPLGYTWGFADNGNRAAESVLEISPNINYTVSGESMPYLLSTDGSLAVQKDVKGLTAGGKNNVVRRMFVVNDPSFPPGTQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAAAAAAAGGDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAAKSHFSSIGALHLTQEECNEILIKRAIAAGHHQTHTITAADGSHHHASGGTPIQVQKVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQASLRQLWRGIPHQGRTASACEDGAQWRQSQHEQCHHHSKSTATAGPSSPSWTANASADHNRGEQSGQLYVADCIHHGCQWRGTTAVCVPRMRQCF
Protein: NADH dehydrogenase subunit 4L (Q2F914)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDPIKYFTFSMIISILGIRGILLNRRNILIMSMPIESMLLAVNLNFLVFSVSLDDMMGQSFASLVPTVAAAESAIGLAIFVITFRVRGTIAVEFINCIQG
Protein: Large ribosomal subunit protein bL27c (50S ribosomal protein L27, chloroplastic) (CL27) (Q9FLN4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Large ribosomal subunit protein bL28c
- Large ribosomal subunit protein uL24c
- Large ribosomal subunit protein bL9c
- Small ribosomal subunit protein uS9c
- Large ribosomal subunit protein uL6c
- Large ribosomal subunit protein uL4c
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- 50S ribosomal protein L33
- Large ribosomal subunit protein bL31c
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
Sequence:
MAMATSMSLNLIGAFKGLSLSSTSSFLRGDLSFSPKTSFTVTLPLENLQAPIPLTIESAHKKGAGSTKNGRDSPGQRLGVKIYGDQVAKPGAIIVRQRGTKFHAGKNVGIGKDHTIFSLIDGLVKFEKFGPDRKKISVYPREIVPENPNSYRARKRENFRLQREKKKARRENYSYTLPTPELVLASASVDDAEANPEC
Protein: 15-cis-phytoene synthase (EC 2.5.1.32) (Q6ED64)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MAAITLLRSASLPGLSDALARDAAAVQHVCSSCLPSNNKEKKRRWILCSLKYACLGVDPAPGEIARTSPVYSSLTVTPAGEAVISSEQKVYDVVLKQAALLKRHLRPQPHTIPIVPKDLDLPRNGLKQAYHRCGEICEEYAKTFYLGTMLMTEDRRRAIWAIYVWCRRTDELVDGPNASHITPSALDRWEKRLDDLFTGRPYDMLDAALSDTISKSPIDIQPFRDMIEGMRSDLRKTRYKNFDELYMYCYYVAGTVGLMSVPVMGIAPESKATTESVYSAALALGIANQLTNILRDVGEDARRGRIYLPQDELAEAGLSDEDIFNGVVTNKWRSFMKRQIKRARMFFEEAERGVTELSQASRWPVWASLLLYRQILDEIEANDYNNFTKRTYVGKAKKLLALPVAYGRSLLMPYSLRNSQK
Protein: Serine/threonine/tyrosine protein kinase (A0A1D8PTW7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Spindle assembly checkpoint component MAD2
- Probable kinetochore protein NDC80
- Spindle assembly checkpoint component MAD1
- Kinesin-like protein
- Probable kinetochore protein NUF2
- Protein kinase
- Condensin subunit
- separase
- Ase1p
- Kinesin-like protein
Sequence:
MPHDLLSHVATSFSSHRSSPSSNNSTKRRLALEDDPTVLPPALSSYSIQCLNERTKTSTLPSQITGKYELDFPDSSSKRDNTLRNKLAAHFTNESTRSREISNSFTNLSEDRSSINTAATTTPGSKTFEDLRSKRKRRFGKSLGPPKRGTDFVQESTPIGDELSPKIESKFNITPQHKSLSEIIPKAPSLERFSPLLKKNHSSIDAEDTITKRIEARRREQMEQEFVKKEKENELAELKIKKLEQIAALQSPYEEHKSKEFQEPKQSRMPLREIPVNSAVDVFRKPKAPKSAISPSPNVQSNSMIPPAQPVFRNTLQDFPKPPQQPQASSQNQQQVLPSAPIPPKAHYDRPQHSGNKRALIINDKSYEKLELIGKGGSSKVYRVRSLNNNCVYALKKVELGQFEDVSGFKGEIDLLTKLKSCERVVTLVDYATTESSLYLIMEKGDLDLAEVLQYRLKLDAPLDLNFVKYHTIEMFKCIKDVHDAGIVHSDLKPANFLFVRGMLKIIDFGIANAVPDHTINVYRENQIGTPNYMAPEAICESNYTSARIWKVGKPSDIWSIGCILYQFIYGKAPFAGYSGNQKLMAITNPHIKISFPSSGIGNTPVPVSAIELMKNCLHRDPNDRWTIEQCLTCDFLSPKIVSENFIREVVHQSINYGYNSRISGDGMTSDRYDALVDSVMKQIQNLNYS
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (O96435)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRVQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEGYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGYYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDILYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAMLTGVLFLVIFIIATVYFMRSKHQDDLDKKCTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGHFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFETLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGLGLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQIFFISTDLWLEHIKMSRYCHHFKEANLINAQQVNSSNYHFCINQFFIVKY
Protein: Autophagy-related protein 2 (Q95TX2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Preautophagosomal structure membrane {ECO:0000256|ARBA:ARBA00004623}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004623}.
Interaction partners:
Sequence:
MSGCTLRLLAEDCVLQLGLVKEESNDSLIPVLNLGLLNISFRLNAEGSGQPRVDLRSSIHDMHLKTCYDSAAALAQLIAYVANDRDLCPPEEPILNEDTKPAEPKPNEEHEMSDHTQNHVSKLMADAVIDVESSPNLRAMKSPGGREEGIEIFYFPDEPKEKRKSTSAKLQTKSLMVESPSVIGDILDFESNVILQSYYHQSQVQPQTSLGSQVQQELGSLGNASLEERDFDIIHDEEISRMDKFGVKQIYISEDPLQIVDNHFELPHEKVDLLRPPSNFPVAESTYTLCEMTFTWHLYGGRDFPDEPLKKSSSSATSGFGMSDTYKYGVSQAQEQDKQDKKGSKKGLLKQPKGSQRNLEVLVEMQLSKIRFSYETYPLTSMYSSRQVLLVSEIEIRDRLRSSDINKFLYHPTGNNLSHKPDENMVIVKALNVRPNPQKSSAEECSLRVSILPIKLNIDQDTLLFLEDFFSGMFRNSASAAGGTKTEGSSSSATDMPVMSVSKMPEELSDKLPDSEVKEMVERNLNVLIEENSLDVELEEDPATAPPVFFREVIFSPALPICFDYHGRRIELSRGPVTGLIMGLAQLQGSGINLREIVNRRGILGWNKLCEFLAKEWLKDIKRNQLPNILSGIGPTNAVLQLFQGIYDLFRLPIEQYNKDGRIIRGFQLGAQSFTARTALAALEITSRIIHLLQFTAETTFDMLSAGPSMKKRKGGRQGKRRRQGRPKDLREGVANAYTIVREGINESANTLIEAAITEHDQKGYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLIPEAKLEARDKWKQEIH
Protein: Protein screw (P54631)
Organism: Drosophila melanogaster (Fruit fly)
Function: Part of the signal that specifies dorsal cell fates in the embryo. Acts together with dpp.
Subcellular location: Secreted.
Interaction partners:
- receptor protein serine/threonine kinase
- Protein twisted gastrulation
- receptor protein serine/threonine kinase
- Dorsal-ventral patterning protein Sog
- Protein decapentaplegic
- Dorsal-ventral patterning protein tolloid
- Serine/threonine-protein kinase receptor
- receptor protein serine/threonine kinase
- Mothers against decapentaplegic homolog
- LD29161p
Sequence:
MLNVFFLTSLFYAASATTYVTTNNHIEMPIYQKRPLSEQMEMIDILDLGDRPRRQAEPNLHNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLDDDILISNEDRQEIASCNSILTFSSRLKPEQLDNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRANFTVSVYRKLDNRQDFSYRILGSVNTTSSQRGWLEFNLTDTLRYWLHNKGLQRRNELRISIGDSQLSTFAAGLVTPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPHLPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGCH
Protein: Coiled-coil domain containing 196 (A0A1B0GWI1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTSGANSSGSYLPSEIRSSKIDDNYLKELNEDLKLRKQELLEMLKPLEDKNNLLFQKLMSNLEEKQRSLQIMRQIMAGKGCEESSVMELLKEAEEMKQNLERKNKMLRKEMEMLWNKTFEAEELSDQQKAPQTKNKADLQDGKEKQQRKMEWVKYQEQNNILQNDFHGKVIELRIEALKNYQKANDLKLSLYLQQNFEPMQAFLNLPGSQGIRIV
Protein: Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) (P05708)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (By similarity). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P19367}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19367}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P19367}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane. Dissociates from the mitochondrial outer membrane following inhibition by N-acetyl-D-glucosamine, leading to relocation to the cytosol. {ECO:0000250|UniProtKB:P19367}.
Interaction partners:
- Non-selective voltage-gated ion channel VDAC1
- Pyruvate kinase PKM
- Non-selective voltage-gated ion channel VDAC2
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Glucose-6-phosphate isomerase
- GDH/6PGL endoplasmic bifunctional protein
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
- Cytoplasmic dynein 1 heavy chain 1
- Solute carrier family 2, facilitated glucose transporter member 3
- Fructose-bisphosphate aldolase A
Sequence:
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKGAALITAVGVRLRGDPSIA
Protein: Calmodulin-like protein 6 (Calglandulin-like protein) (Q8TD86)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15621662}. Nucleus {ECO:0000269|PubMed:15621662}.
Interaction partners:
- Nitric oxide synthase 1
- Nitric oxide synthase 3
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Ryanodine receptor 1
- Ryanodine receptor 2
- Voltage-dependent L-type calcium channel subunit alpha-1C
- GTPase KRas
- Myosin light chain kinase 2, skeletal/cardiac muscle
- Calcium/calmodulin-dependent protein kinase type IV
- Myosin light chain kinase, smooth muscle
Sequence:
MGLQQEISLQPWCHHPAESCQTTTDMTERLSAEQIKEYKGVFEMFDEEGNGEVKTGELEWLMSLLGINPTKSELASMAKDVDRDNKGFFNCDGFLALMGVYHEKAQNQESELRAAFRVFDKEGKGYIDWNTLKYVLMNAGEPLNEVEAEQMMKEADKDGDRTIDYEEFVAMMTGESFKLIQ
Protein: Suppressor of presenilin-2 (Q7JMA9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSEEPAAKRMKNADEFPNLRSEVAGPVKEKLIELDAIQHQLDVMSENAAEEVLKVEQIFNQKRLPIYEKRKKLTTKIDNFWQTAFLNHHLLSTAIPEEQEDLLAALRDLEVQEFEDLRSGFKIIMTFDPNEYFTNEVITKSYHLQSESPSTEITEIEWKENKKPPFKPEDGDSAHTFLEWLTYAALPDSDEIAEVIKDDLYVNPLQYYVMPDMQEVEEDDIEDFLNEERGVDENGQRIPRRNISDSLKVDQDESADGQEGEDEEEEDMGEEEEDGVEEEAEGEEEEEDGAIEEEGGDENVEAHVAVNPENTAE
Protein: Palmitoyltransferase ZDHHC11 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11) (DHHC-11) (Zinc finger protein 399) (Q9H8X9)
Organism: Homo sapiens (Human)
Function: Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (By similarity). May play a role in cell proliferation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16647879}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Palmitoyltransferase ZDHHC3
Sequence:
MDTRSGSQCSVTPEAILNNEKLVLPPRISRVNGWSLPLHYFQVVTWAVFVGLSSATFGIFIPFLPHAWKYIAYVVTGGIFSFHLVVHLIASCIDPADSNVRLMKNYSQPMPLFDRSKHAHVIQNQFCHLCKVTVNKKTKHCISCNKCVSGFDHHCKWINNCVGSRNYWFFFSTVASATAGMLCLIAILLYVLVQYLVNPGVLRTDPRYEDVKNMNTWLLFLPLFPVQVQTLIVVIIGMLVLLLDFLGLVHLGQLLIFHIYLKAKKMTTFEYLINNRKEESSKHQAVRKDPYVQMDKGVLQQGAGALGSSAQGVKAKSSLLIHKHLCHFCTSVNQDGDSTAREGDEDPCPSALGAKARNSRLICRRLCQFSTRVHPDGGSMAQEADDAPSISTLGLQQETTEPMKTDSAESED
Protein: Invertase (EC 3.2.1.26) (Beta-fructofuranosidase) (Saccharase) (O59852)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Hexokinase-1
- Hexokinase-2
- Alpha-glucosidase
- Alpha-galactosidase mel1
- Alpha-glucosidase
- Putative beta-glucosidase
- Putative invertase
- Glucan 1,3-beta-glucosidase
- Uncharacterized family 31 glucosidase C30D11.01c
- Uncharacterized family 31 glucosidase C1039.11c
Sequence:
MFLKYILASGICLVSLLSSTNAAPRHLYVKRYPVIYNASNITEVSNSTTVPPPPFVNTTAPNGTCLGNYNEYLPSGYYNATDRPKIHFTPSSGFMNDPNGLVYTGGVYHMFFQYSPKTLTAGEVHWGHTVSKDLIHWENYPIAIYPDEHENGVLSLPFSGSAVVDVHNSSGLFSNDTIPEERIVLIYTDHWTGVAERQAIAYTTDGGYTFKKYSGNPVLDINSLQFRDPKVIWDFDANRWVMIVAMSQNYGIAFYSSYDLIHWTELSVFSTSGYLGLQYECPGMARVPVEGTDEYKWVLFISINPGAPLGGSVVQYFVGDWNGTNFVPDDGQTRFVDLGKDFYASALYHSSSANADVIGVGWASNWQYTNQAPTQVFRSAMTVARKFTLRDVPQNPMTNLTSLIQTPLNVSLLRDETLFTAPVINSSSSLSGSPITLPSNTAFEFNVTLSINYTEGCTTGYCLGRIIIDSDDPYRLQSISVDVDFAASTLVINRAKAQMGWFNSLFTPSFANDIYIYGNVTLYGIVDNGLLELYVNNGEKTYTNDFFFLQGATPGQISFAAFQGVSFNNVTVTPLKTIWNC
Protein: Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) (P69735)
Organism: Rattus norvegicus (Rat)
Function: Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of Rab3gap1 and Rab3gap2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (By similarity). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (By similarity). Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (By similarity). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9733780}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q15042}. Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:Q15042}. Note=In neurons, it is enriched in the synaptic soluble fraction. {ECO:0000269|PubMed:9733780}.
Interaction partners:
- Rab3 GTPase-activating protein non-catalytic subunit
- Ras-related protein Rab-18
- Nocturnin
- Solute carrier family 38 member 6
- Dmx-like 2
- Ras-related protein Rab-3A
- WD repeat-containing protein 7
Sequence:
MAADSEPESEVGCPLTPLPPVSIAIRFTYVLQDWQQYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYSDLDPVQAPHWSVRVRKADNPQCLLGDFVTEFLKICRRKESTDEILGRSTFEEEGRVADITHALSKLTEPAPVPIHKLSVSNMVHTAKKKIRKHRGEESPLNNDVLNTILLFLFPDAASEKPLDGTTSVDNSNPAAEAGDYTLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSPSDSMTKAYPADAGKAGGQLGLDHLRDTEKEKGEAGKSWDSWSDSEEEFFECLSDAEDLRGNGQESTKKGGPKDMAPLKPEGRLHQHGKLTLLRNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCCLEDFVRWYSPRDYIEEEVTDEKGNVVLKGELSARMKIPSNMWVEAWETAKPVPARRQRRLFDDTREAEKVLHYLAMQKPADLARHLLPCVIHAAVLKVKEEESLENIPSVKKIIKQIIAHSSKVLRFPSPEDKKLEEIILQITTVEAIIARARSLKAKFGTEKCEHEEEKEDLERFVSCLLEQPEVAVTGAGRGHAGRIIHKLFVNAQRAAAVALPEEELKRSGCPEERRQTLVSDFPPPAGRELILRATVPRPAPYSKALPQRMYSVLTKEDFRLAGAFSSDTSFF
Protein: Beta-crystallin B2 (Beta-B2 crystallin) (Beta-crystallin Bp) (P62696)
Organism: Mus musculus (Mouse)
Function: Crystallins are the dominant structural components of the vertebrate eye lens.
Interaction partners:
- Alpha-crystallin A chain
- Alpha-crystallin B chain
- Gap junction alpha-8 protein
- Lens fiber major intrinsic protein
- Gap junction alpha-3 protein
- Phakinin
- Filensin
- Gamma-crystallin S
- Beta-crystallin A1
- Heat shock factor protein 4
Sequence:
MASDHQTQAGKPQPLNPKIIIFEQENFQGHSHELSGPCPNLKETGMEKAGSVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGKKMEIVDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDNSDFGAPHPQVQSVRRIRDMQWHQRGAFHPSS