wanglab/gogpt-training-data huggingface dataset:
Protein: Ubiquitin carboxyl-terminal hydrolase 53 (EC 3.4.19.12) (Per-hexamer repeat protein 3) (Protein mambo) (Ubiquitin-specific peptidase 53) (P15975)
Organism: Mus musculus (Mouse)
Function: Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions. Has no peptidase activity.
Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:26609154}.
Interaction partners:
Sequence:
MAWVKFLRKPSGNLGKAYQAGSLLSLAPTVGLLNEPGQNSCFLNSAVQVLWQLDIFRRSLRALTGHICQGDACIFCALKTIFAQFQHSREKALPSDNIRHALAESFKDEQRFQLGLMDDAAECFENILARIHFHLVPNRDADMCTSKSCVTHQKFAMTLYEQCVCRSCGASSDPLPFTELVRYISTTALCNEVERMMERHERVKPEMFAELLQAANTADDYRKCPSNCGQKIKIRRVLMNCPEIVTIGLVWDSEHSDLTEDVVRSLATHLYLPGLFYRVTDENATDSELHLVGMICYTSRHYCAFAFHTKSSKWVFFDDAHVKEMGTRWKDVVSKCIRCHLQPLLLFYANPDGTAVSTEDALRQVVHWSHYRSGEENMGCGKPIIYKPDNSKENGFGGQTKQKENHKFQTDISSLNRSQMQTSGRRAPVKLSHDQREKIKDISRECALKAIEQKNALSSQRKDLEKGQRKDTGRHRDLVDEVLASFKSGSPPASDGFRQQGNPHLYHSQGKGPCKHDRATHESYTSGKVISSSKSQNLLVPGEKTTGKAKSDSGTGYETDSSQDSRDKGGSYSSKTKSRHRGWKPMRETLNVDSVFSESEKRQHSPRRKSDIGSRPRCSKDQSFNNWPKANPKQKGLMTIYEDEMKQEAGSRSSLETNGKGAEKNLSAAESRGPGTSWQMQRTESGYESSDHVSNGSASLDSPGVEGSGAVMDVGGGKAFSEHIKMNSHNMDSMEYISHHCKDHPEGFRKELQDLEADDKIHELHPESHVQIKSHLIKRSQIGETNDKLFPSASPQTLAREHVYQTNEHKVERPDRSKCSERHNTENSEGTGLPFHVDESSVAGKRVDSNETVSPSSLPSSVRTAGLKPETGPLMFWSQQNITEQGYSDNSLSRELTLLSACNADSCQMPKLHCHRSPPPLPPKKYSTASAPRLERVGLSPDVGVTEAFNTNPSSLPKHSLSPASGPSLEGSPCMTQERDKETIQVKQLAANSYPSSCSTNSFQPDQDSTSVCPNETISLTTYFSVDSCMTDTYRLKYHQRPKLYFPESSGHHSNNSLSQTEQVEGSIT
Protein: Neuromedin-K receptor (NK-3 receptor) (Neurokinin B receptor) (Tachykinin receptor 3) (F1R3V0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Preprotachykinin 2a
- Tachykinin precursor 3b.
- Tachykinin receptor 3a
- Neuromedin-K receptor
Sequence:
MAGPQSGSNVTRNFTNQFVQPPWRVAVWSVAYSSVLAVAVFGNLIVIWIILAHKRMRTVTNYFLLNLAFSDASMAAFNTLINFIYATHGEWYFGEVYCKFHNFFPVTAVFASIYSMTAIAVDRYMAIIHPLKPRLSATATKVVIVCIWALAVILAFPLCFYSTTRTMPRRTICYVAWPRPAEDSFMYHIIVTVLVYMLPLVVMGITYTIVGVTLWGGEIPGDSSDNYVGQLRAKRKVVKMMIVVVVTFALCWLPYHIYFIVTGLNKRLNKWKSIQQVYLSVLWLAMSSTMYNPIIYCCLNGRFRAGFKRAFRWCPFIQVSSYDELELRPTRLHPRNQSSMCTLSRVDTSLHGEDPRRSQRKSTKSQCLVEVRDENTPATKLCLNRDQAFATEQLS
Protein: Nrp2 protein (Q8K2T3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
QISASSTREYLWSPSAARLVSSRSGWFPRNPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQTKLFEGNMHYDTPDIRRFDPVPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPMDEDATECGENCSFEDDKDLQLPSGFNCNFDFPEETCGWVYDHAKWLRSTWISSANPNDRTFPDDKNFLKLQSDGRREGQYGRLISPPVHLPRSPVCMEFQYQAMGGHGVALQVVREASQESKLLWVIREDQGSEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEISIDDIRISTDVPLENCMEPISAFADEYEGDWSNSSSSTSGAGDPSSGKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKINHQKCCSEA
Protein: Basic helix-loop-helix transcription factor amos (Absent MD neurons and olfactory sensilla protein) (Amos protein) (Reduced olfactory organs protein) (Rough eye protein) (Q9Y0A7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription factor involved in early neurogenesis; sensillum basiconica formation and maybe sensillum trichodea development. Promotes multiple dendritic (MD) neuron formation. Required for olfactory sensilla; regulated by lozenge (lz).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Achaete-scute complex protein T4
- Achaete-scute complex protein T5
Sequence:
MLTNNELMEQFYFPDEAPAIPEFLSNDTFQQLEQLMYQQEFSTSDSQSDGANSCSLEMYYDTPSVLELEHMLNAQEQQQHHLQANPLGKNQGRSPRYWNKQQRSKPYDKLSTSMSSSTSSASSSSSSSAGFGGEVLKKRRLAANARERRRMNSLNDAFDKLRDVVPSLGHDRRLSKYETLQMAQAYIGDLVTLLSRDY
Protein: Ribonuclease VapC19 (RNase VapC19) (EC 3.1.-.-) (Toxin VapC19) (P9WF93)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB19.
Subcellular location: Secreted. Note=Following 6 weeks of nutrient starvation. {ECO:0000269|PubMed:23345537}.
Interaction partners:
- Putative antitoxin VapB19
- Ribonuclease VapC29
- Ribonuclease VapC1
- Ribonuclease VapC37
- Ribonuclease VapC18
- Ribonuclease VapC25
- 23S rRNA-specific endonuclease VapC20
Sequence:
MKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLARRYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
Protein: Ankyrin repeat domain-containing protein 2A (AtAKR2) (Q9SAR5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Exhibits chaperone activity toward chloroplast outer envelope membrane, mitochondrion outer membrane, endoplasmic reticulum membrane and peroxisomal proteins, by recruiting specific proteins containing a single transmembrane associated with an AKR2A-binding sequence (ABS) and subsequently binding glycolipids (e.g. monogalactosyldiacylglycerol (MGDG) and phosphatidylglycerol (PG)) present in the membrane of the target organelle. Seems to be involved in the regulation of hydrogen peroxide levels during biotic and abiotic stresses by optimizing the ascorbate peroxidase 3 (APX3) hydrogen peroxide-degrading activity. This regulation might be monitored by GRF6. Cytosolic targeting factor for chloroplast outer membrane (COM) proteins that mediates sorting and targeting of nascent chloroplast outer envelope membrane (OEM) proteins to the chloroplast. Facilitates the targeting of OEP7 to chloroplasts. Facilitates the targeting of APX3 to peroxisomes. Involved in cellular metabolism (e.g. peroxisome activity) and required for plant growth and development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20215589}. Nucleus {ECO:0000269|PubMed:20215589}. Plastid, chloroplast outer membrane {ECO:0000269|PubMed:25203210}; Peripheral membrane protein {ECO:0000269|PubMed:25203210}; Cytoplasmic side {ECO:0000269|PubMed:25203210}.
Interaction partners:
- Outer envelope membrane protein 7
- L-ascorbate peroxidase 3
- 17.8 kDa class I heat shock protein
- Translocase of chloroplast 34, chloroplastic
- Ankyrin
- Translocase of chloroplast 33, chloroplastic
- Protein TOC75-3, chloroplastic
- Outer envelope protein 64, chloroplastic
- Translocase of chloroplast 159, chloroplastic
- Ankyrin repeat-containing protein BDA1
Sequence:
MASNSEKNPLLSDEKPKSTEENKSSKPESASGSSTSSAMPGLNFNAFDFSNMASILNDPSIREMAEQIAKDPAFNQLAEQLQRSIPNAGQEGGFPNFDPQQYVNTMQQVMHNPEFKTMAEKLGTALVQDPQMSPFLDAFSNPETAEHFTERMARMKEDPELKPILDEIDAGGPSAMMKYWNDPEVLKKLGEAMGMPVAGLPDQTVSAEPEVAEEGEEEESIVHQTASLGDVEGLKAALASGGNKDEEDSEGRTALHFACGYGELKCAQVLIDAGASVNAVDKNKNTPLHYAAGYGRKECVSLLLENGAAVTLQNLDEKTPIDVAKLNSQLEVVKLLEKDAFL
Protein: Trafficking protein particle complex II-specific subunit 120 (TRAPP II-specific subunit 120) (Transport protein particle 120 kDa subunit) (Q04183)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchanger (GEF) for the Golgi YPT1 GTPase. TRS120 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS130.
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:11239471}.
Interaction partners:
- Trafficking protein particle complex II-specific subunit 130
- Trafficking protein particle complex subunit 23
- Trafficking protein particle complex subunit BET5
- Trafficking protein particle complex subunit 20
- Trafficking protein particle complex II-specific subunit 65
- Trafficking protein particle complex subunit 33
- TRAPP-associated protein TCA17
- Trafficking protein particle complex subunit BET3
- Trafficking protein particle complex subunit 31
- Trafficking protein particle complex III-specific subunit 85
Sequence:
MNILKHFPSYVGPSKIRTLVIPIGHWTRKEFNNAVQKLSEFNEIHLSDVTPIDSPIFTPQGFPHGKLFFDFLTIDHDDALELFLYDFEPFRKTFVIIGLVNDYSDPLTNLNFMKEKYPTLISPNLVYASSTPTKELEQTIDTMENVFASSPDMQKNIETIMCDIARNFLTALNSYYSSYKHVTLRSPGAIGGNAVLKTTLIRQNSYTSSSSSTPMSAVQSSVSSSSKAGSVTTASKRLSSFEMTTNSLKRSASLKLATTLSTSENRSQQKSLGRQMKILGNFQLLAGRYVDALNSFVDAITTLYKVRDYLWLGSALDGISICFLLLSYLGLSYQIPQIVSLICPVEKLNFESSSTGISPVDSNSKATASTTASSTPRNSISIAAMQSPRNSIMSLSAPALNIDVENINLPLLIKCISDKVLYYYDLSLMHNSEYAPQVVYCEFLLKTLTFMTSCYKSSEFSKDVLDNIVKNQHRALSDIPNSPMFPRFEVYFYSNKLFELQLKEMQVEAQIKIYSTMAEVYRLLGYKRKQLFVLRLLMVALLATPNKIAWHPDYRTLIDTIIELLNINESEAKINVDDPSQSTWLILQKKILQLCIKVSRKINDFEYVAKFSSILITKYTHLLNQSEQDALFKEYIQPSITNESITSYWDPFILREVVINRILDSDPTSNEIPLESDVSSLESLENRQKTQDINPQEVFNPFKRVQPTSFVSNNSTKVPILVFLVGDKAEFTCRVQNPFKFDFTINDIQLDEEISEFCEIDRKAVSYSGPYNVKAESIRSITLPLIIKKPTYKKIYEISCLKISILKLPLQKFDIINDSRRSNPVEEEAEYSKCIYGKLKIKILPEQPQLELLSTSKMTRNSWMMLDGTKTDFHITVRNKSLSCAINHIKIIPMNNIEQMLKPDYWKKMPPDDLYIMEKQLDWLSKSCVRIIKLPTVIKPNETITFDLELDNTAVPFNFTGFDLLIEYGMSATDESCIYLKKLSIPYEVTLRRTIEVPSMDIIPLNELFSSQVENVDWIEYVMSKIRAESNLHSRDFILLLLDFRNSWIDGIKLNVQFEDFTSNEYHVEASHTSRIIVPIKKIDYKKYNFENTPIPRIYPGRQFIQSGLNEEQTIEMRQKFWCREHIISKLKCNWKLTTDQSVTGSVDFNKFIEKFDHKMVYTIYPGRLFYGVQLLLDEPKVKVGEIINLKIITEPTSTCRRKQNSTVNFLDIVIFDSKTSKILPRSNRRILYNGSLTKPISTTKVSEINLEIIPIEKGRYEFSVCISKSNNQDGIIQFDSENVILSVI
Protein: Flagellar biosynthesis protein FlhA (P76298)
Organism: Escherichia coli (strain K12)
Function: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
- Flagellar biosynthetic protein FliQ
- Flagellar M-ring protein
- Flagellar biosynthetic protein FlhB
- Flagellar motor switch protein FliM
- Flagellar biosynthetic protein FliR
- Flagellum-specific ATP synthase
- Flagellar assembly protein FliH
- Flagellar protein FliO
- Flagellar biosynthetic protein FliP
- Flagellar secretion chaperone FliS
Sequence:
MSNLAAMLRLPANLKSTQWQILAGPILILLILSMMVLPLPAFILDLLFTFNIALSIMVLLVAMFTQRTLEFAAFPTILLFTTLLRLALNVASTRIILMEGHTGAAAAGKVVEAFGHFLVGGNFAIGIVVFVILVIINFMVITKGAGRIAEVGARFVLDGMPGKQMAIDADLNAGLIGEDEAKKRRSEVTQEADFYGSMDGASKFVRGDAIAGILIMVINIVGGLLVGVLQHGMSMGHAAESYTLLTIGDGLVAQIPALVISTAAGVIVTRVSTDQDVGEQMVNQLFSNPSVMLLSAAVLGLLGLVPGMPNLVFLLFTAGLLGLAWWIRGREQKAPAEPKPVKMAENNTVVEATWNDVQLEDSLGMEVGYRLIPMVDFQQDGELLGRIRSIRKKFAQEMGFLPPVVHIRDNMDLQPARYRILMKGVEIGSGDAYPGRWLAINPGTAAGTLPGEATVDPAFGLNAIWIESALKEQAQIQGYTVVEASTVVATHLNHLISQHAAELFGRQEAQQLLDRVAQEMPKLTEDLVPGVVTLTTLHKVLQNLLDEKVPIRDMRTILETLAEHAPIQSDPHELTAVVRVALGRAITQQWFPGKDEVHVIGLDTPLERLLLQALQGGGGLEPGLADRLLAQTQEALSRQEMLGAPPVLLVNHALRPLLSRFLRRSLPQLVVLSNLELSDNRHIRMTATIGGK
Protein: Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) (P30967)
Organism: Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / CCUG 213 / NBRC 12614 / NCIMB 9131 / NCTC 9757 / MK)
Interaction partners:
- Putative pterin-4-alpha-carbinolamine dehydratase
- 4-hydroxyphenylpyruvate dioxygenase
- Homogentisate 1,2-dioxygenase
- Aminotransferase
- Putative 8-amino-7-oxononanoate synthase
- Bifunctional chorismate mutase/prephenate dehydratase
- Histidinol-phosphate aminotransferase
- Putative 8-amino-7-oxononanoate synthase
- Probable acetyltransferase
- N-acetyltransferase domain-containing protein
Sequence:
MNDRADFVVPDITTRKNVGLSHDANDFTLPQPLDRYSAEDHATWATLYQRQCKLLPGRACDEFMEGLERLEVDADRVPDFNKLNQKLMAATGWKIVAVPGLIPDDVFFEHLANRRFPVTWWLREPHQLDYLQEPDVFHDLFGHVPLLINPVFADYLEAYGKGGVKAKALGALPMLARLYWYTVEFGLINTPAGMRIYGAGILSSKSESIYCLDSASPNRVGFDLMRIMNTRYRIDTFQKTYFVIDSFKQLFDATAPDFAPLYLQLADAQPWGAGDVAPDDLVLNAGDRQGWADTEDV
Protein: Gap junction delta-2 protein (Connexin-36) (Cx36) (Gap junction alpha-9 protein) (O54851)
Organism: Mus musculus (Mouse)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Interaction partners:
- Tight junction protein 1
- Gap junction gamma-1 protein
- Gap junction alpha-1 protein
- Mitogen-activated protein kinase 3
- Cyclin-dependent kinase 1
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 7
- Tight junction protein 2
- Gap junction beta-2 protein
- Gap junction alpha-3 protein
Sequence:
MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPAESIGGPGGTGGGGSGGSKREDKKLQNAIVNGVLQNTETTSKETEPDCLEVKELTPHPSGLRTAARSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV
Protein: Cation channel sperm-associated protein 2 (CatSper2) (A2ARP9)
Organism: Mus musculus (Mouse)
Function: Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:11675491}; Multi-pass membrane protein {ECO:0000269|PubMed:34225353}.
Interaction partners:
- Cation channel sperm-associated auxiliary subunit delta
- Cation channel sperm-associated protein 3
- Cation channel sperm-associated protein 4
- Cation channel sperm-associated protein 1
- EF-hand calcium-binding domain-containing protein 9
- Cation channel sperm-associated auxiliary subunit epsilon
- Cation channel sperm-associated auxiliary subunit beta
- Cation channel sperm-associated auxiliary subunit zeta
- Cation channel sperm-associated auxiliary subunit gamma 2
- Solute carrier organic anion transporter family member 6C1
Sequence:
MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDDKSDATESDNEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEKVKEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK
Protein: Meiotic recombination protein SPO11-1 (OsSPO11-1) (EC 5.6.2.2) (OsSPO11A) (Putative topoisomerase VI subunit A1) (OsTOP6A1) (Q7Y021)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Is essential for both homologous chromosomes pairing and crossover formation during meiosis.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA topoisomerase 6 subunit B
- Meiotic recombination protein DMC1 homolog A
- Crossover junction endonuclease MUS81
- Meiotic recombination protein SPO11-2
- Meiotic recombination protein DMC1 homolog B
- Double-strand break repair protein MRE11
- DNA repair protein RAD51 homolog 3
- Protein PAIR1
- DNA mismatch repair protein MSH5
- Pachytene checkpoint protein 2 homolog
Sequence:
MAGREKRRRVAALDGEERRRRQEEAATLLHRIRGLVRWVVAEVAAGRSPTVALHRYQNYCSSASAAAASPCACSYDVPVGTDVLSLLHRGSHASRLNVLLRVLLVVQQLLQQNKHCSKRDIYYMYPSIFQEQAVVDRAINDICVLFKCSRHNLNVVPVAKGLVMGWIRFLEGEKEVYCVTNVNAAFSIPVSIEAIKDVVSVADYILIVEKETVFQRLANDKFCERNRCIVITGRGYPDIPTRRFLRYLVEQLHLPVYCLVDADPYGFDILATYKFGSLQLAYDANFLRVPDIRWLGVFTSDFEDYRLPDCCLLHLSSEDRRKAEGILSRCYLHREAPQWRLELEAMLQKGVKFEIEALSACSISFLSEEYIPKKIKQGRHI
Protein: Ubiquitin receptor RAD23b (AtRAD23b) (Putative DNA repair protein RAD23-1) (RAD23-like protein 1) (AtRAD23-1) (Q84L33)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).
Subcellular location: Nucleus {ECO:0000269|PubMed:20086187}. Cytoplasm {ECO:0000269|PubMed:20086187}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- DNA repair protein RAD4
- Peptide-N
- Probable ubiquitin conjugation factor E4
- 26S proteasome regulatory subunit RPN13
- Ubiquitin domain-containing protein DSK2b
- Calcium-binding protein CML19
- Protein DNA-DAMAGE INDUCIBLE 1
- Probable calcium-binding protein CML20
- Protein NBR1 homolog
Sequence:
MKLTVKTLKGSHFEIRVLPSDTIMAVKKNIEDSQGKDNYPCGQQLLIHNGKVLKDETSLVENKVTEEGFLVVMLSKSKSGGSAGQASVQTSSVSQPVSATTSSTKPAAPSTTQSSPVPASPIPAQEQPAAQTDTYGQAASTLVSGSSLEQMVQQIMEMGGGSWDKETVTRALRAAYNNPERAVDYLYSGIPQTAEVAVPVPEAQIAGSGAAPVAPASGGPNSSPLDLFPQETVAAAGSGDLGTLEFLRNNDQFQQLRTMVHSNPQILQPMLQELGKQNPQLLRLIQENQAEFLQLVNEPYEGSDGEGDMFDQPEQEMPHAINVTPAEQEAIQRLEAMGFDRALVIEAFLACDRNEELAANYLLENSGDFED
Protein: PiggyBac transposable element-derived protein 1 (Cerebral protein 4) (Q96JS3)
Organism: Homo sapiens (Human)
Interaction partners:
- Zinc finger protein with KRAB and SCAN domains 4
- SCAN domain-containing protein 1
- Zinc finger protein 446
- Zinc finger and SCAN domain-containing protein 18
- Zinc finger protein 396
- Zinc finger protein 24
- Zinc finger and SCAN domain-containing protein 32
- Zinc finger protein with KRAB and SCAN domains 3
- Zinc finger and SCAN domain-containing protein 20
- Zinc finger and SCAN domain-containing protein 1
Sequence:
MYEALPGPAPENEDGLVKVKEEDPTWEQVCNSQEGSSHTQEICRLRFRHFCYQEAHGPQEALAQLRELCHQWLRPEMHTKEQIMELLVLEQFLTILPKELQPCVKTYPLESGEEAVTVLENLETGSGDTGQQASVYIQGQDMHPMVAEYQGVSLECQSLQLLPGITTLKCEPPQRPQGNPQEVSGPVPHGSAHLQEKNPRDKAVVPVFNPVRSQTLVKTEEETAQAVAAEKWSHLSLTRRNLCGNSAQETVMSLSPMTEEIVTKDRLFKAKQETSEEMEQSGEASGKPNRECAPQIPCSTPIATERTVAHLNTLKDRHPGDLWARMHISSLEYAAGDITRKGRKKDKARVSELLQGLSFSGDSDVEKDNEPEIQPAQKKLKVSCFPEKSWTKRDIKPNFPSWSALDSGLLNLKSEKLNPVELFELFFDDETFNLIVNETNNYASQKNVSLEVTVQEMRCVFGVLLLSGFMRHPRREMYWEVSDTDQNLVRDAIRRDRFELIFSNLHFADNGHLDQKDKFTKLRPLIKQMNKNFLLYAPLEEYYCFDKSMCECFDSDQFLNGKPIRIGYKIWCGTTTQGYLVWFEPYQEESTMKVDEDPDLGLGGNLVMNFADVLLERGQYPYHLCFDSFFTSVKLLSALKKKGVRATGTIRENRTEKCPLMNVEHMKKMKRGYFDFRIEENNEIILCRWYGDGIISLCSNAVGIEPVNEVSCCDADNEEIPQISQPSIVKVYDECKEGVAKMDQIISKYRVRIRSKKWYSILVSYMIDVAMNNAWQLHRACNPGASLDPLDFRRFVAHFYLEHNAHLSD
Protein: ALC-interacting protein 1 (At5g01370) (Q9M035)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cell division cycle 5-like protein
- At3g13230
- Uncharacterized protein
- Zinc finger
- At2g45350/F14N22.7
- At3g15680
- Phosphoglycerate mutase family protein
- Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein
- Glycine-rich protein
- EPIDERMAL PATTERNING FACTOR-like protein 8
Sequence:
MTQRANPKTGCLTAVVRRLLCSGSQQTHPSDNILDSDETLQLLISYEENEEPKKEIKTETETQNDDVSLHPPPPPPPPNVVAKLMGLDHPAPGSKRFRYFDDSGSAVTRSKSVNFMDYILKGHEEEEENEDEKDGQRQCRRVKASVSFREIVPTSARWSSNNQQKKHDFLLLYLDKLDEKRELVGSSSFSRSKRFEKVVEDSKKPPLPPSAPKKKENEKVAKKFKDEPRKVAKKKKSENRNDVNGAKKVRWFLSPSKSKSSSEKTALLGESKNIRADEFIGKESESPENKSNASPVSVLDRDLYDYLILDDDYYFSGGDSESASELSTKQVETATKSSCSSSPAKTKTSTKKENNNSTNNDSEETEFITKLMNMLSDLSEEDMKSSTWVSTSSTKPVDFTQVEDFCVEFGQEILDLVMDQLVDELCI
Protein: AT-rich interactive domain-containing protein 3 (ARID domain-containing protein) (B7ZP08)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369100}.
Interaction partners:
Sequence:
MEALQRQQAARLAQGVGPLAPPRLPLPQPPLLGARTLQAPEGAIGVVGAEEEEGAEDEEGETPLAEEETAEQSHPGARCPNSPSSQSPGIQPHEWTYEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVWREVTRGLSLPTTITSAAFTLRTQYMKYLYPYECETRALSSPGELQAAIDSNRREGRRQAYTAVPLFNLAGPTPRGAPGPASSHGPAPTATPNCPGPTQGSASGLPAHACAQLSPSPVKKEESGIPPPRLALPMGLASEATREKLAPEEPPEKRAVLMGPVDSPRLGAPPSFLPRGKAPLRGILFARRQPVPASLGPTNPPPLPSTGPPSSTLP
Protein: Pyridoxal 5'-phosphate synthase subunit SNO1 (EC 4.3.3.6) (PDX2 homolog 1) (Pdx2.1) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) (Q03144)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform.
Interaction partners:
- Pyridoxal 5'-phosphate synthase subunit SNZ1
- Probable pyridoxal 5'-phosphate synthase subunit SNZ2
- Probable pyridoxal 5'-phosphate synthase subunit SNZ3
- Pyridoxamine 5'-phosphate oxidase
- Putative pyridoxal kinase BUD16
- Probable pyridoxal 5'-phosphate synthase subunit SNO2
- Probable pyridoxal 5'-phosphate synthase subunit SNO3
- Uncharacterized protein YGR017W
- Putative pyridoxal kinase BUD17
- Isoamyl acetate-hydrolyzing esterase
Sequence:
MHKTHSTMSGKSMKVIGVLALQGAFLEHTNHLKRCLAENDYGIKIEIKTVKTPEDLAQCDALIIPGGESTSMSLIAQRTGLYPCLYEFVHNPEKVVWGTCAGLIFLSAQLENESALVKTLGVLKVDVRRNAFGRQAQSFTQKCDFSNFIPGCDNFPATFIRAPVIERILDPIAVKSLYELPVNGKDVVVAATQNHNILVTSFHPELADSDTRFHDWFIRQFVSN
Protein: Putative EG45-like domain containing protein 1 (Plant natriuretic peptide B) (AtEXPR2) (AtPNP-B) (Ath-ExpGamma-1.1) (Q9M0C2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Might have a systemic role in water and solute homeostasis.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- GDSL esterase/lipase At3g26430
- Beta-hexosaminidase 3
- Beta-hexosaminidase 1
- Expansin-like B1
- Acireductone dioxygenase 3-requiring) 3)
- CBS domain-containing protein CBSX3
Sequence:
MSKSIVFFSTVLVFLFSFSYATPGIATFYTSYTPCYRGTQEGVMIAAASDTLWDNGRVCGKMFTVKCSGPRNAVPHPCTGKSVKVKIVDHCPSGCASTLDLSREAFAQIANPVAGIINIDYFP
Protein: Insulin-like growth factor 2 preproprotein (Q2F6J6)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MGITAGKSVLVLLAFLAFASCCYAAYRPSETLCGGELVDTLQFVCGDRG
Protein: Sphinx2, isoform B (Sphinx2, isoform C) (Q9VS71)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Sphinx1
- Spaetzle-processing enzyme
- Serine protease grass
- U6 snRNA phosphodiesterase 1
- trypsin
Sequence:
MKLVVALLVLSLTFSVCEKNKLSPRITGGYRAKPYTIIYLVGIVYAKSPLSSLKFGAGTIISNQWILTVKEVLIFKYIEAHFGSKRAFWGYDILRIYRENFYFHYDKTRIIALVKCPYQKFDRRMSRVRVPAYGARFERYVGNMTMVCGWGTDKRKVRLPTWMRCVEVEVMNNTECAKYHTPLKWYEMCTSGEGFKGVCEGDMGGAVVTMGPNPTFIGIIWLMPTNCSIGYPSVHIRVSDHIKWIKHVSGVGF
Protein: Nicotinate phosphoribosyltransferase pncB1 (NAPRTase pncB1) (EC 6.3.4.21) (P9WJI9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the Preiss-Handler pathway, which is a recycling route that permits the salvage of free nicotinamide (NM) and nicotinic acid (Na) involved in the NAD biosynthesis. Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. It is not able to use nicotinamide. PncB1 contributes to basal NAD level.
Interaction partners:
- Nicotinamidase/pyrazinamidase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Probable nicotinate-nucleotide adenylyltransferase
- CinA-like protein
- NAD-capped RNA hydrolase NudC
- Possible transcriptional regulatory protein NadR
- Nicotinate phosphoribosyltransferase pncB2
- Purine nucleoside phosphorylase
- Glutamine-dependent NAD
- L-aspartate oxidase
Sequence:
MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEALGPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPLVRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA