wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) (Q12769)
Organism: Homo sapiens (Human)
Function: Functions as a component of the nuclear pore complex (NPC). Involved in poly(A)+ RNA transport.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}.
Interaction partners:
- Protein ELYS
- Nuclear pore complex protein Nup133
- Nucleoporin Nup43
- Nuclear pore complex protein Nup98-Nup96
- Nuclear pore complex protein Nup85
- Protein SEC13 homolog
- Nucleoporin Nup37
- Nuclear pore complex protein Nup107
- Nucleoporin SEH1
- Nuclear pore complex protein Nup205
Sequence:
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVKYSESAGGFYYVESGKLFSVTRNRFIHWKTSGDTLELMEESLDINLLNNAIRLKFQNCSVLPGGVYVSETQNRVIILMLTNQTVHRLLLPHPSRMYRSELVVDSQMQSIFTDIGKVDFTDPCNYQLIPAVPGISPNSTASTAWLSSDGEALFALPCASGGIFVLKLPPYDIPGMVSVVELKQSSVMQRLLTGWMPTAIRGDQSPSDRPLSLAVHCVEHDAFIFALCQDHKLRMWSYKEQMCLMVADMLEYVPVKKDLRLTAGTGHKLRLAYSPTMGLYLGIYMHAPKRGQFCIFQLVSTESNRYSLDHISSLFTSQETLIDFALTSTDIWALWHDAENQTVVKYINFEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFCRGTERNLDLSWSELKKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQEALSHPLALHLNPHTNMVCLLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETTISDDVDIARDVICLIKCLRLIEESVTVDMSVIMEMSCYNLQSPEKAAEQILEDMITIDVENVMEDICSKLQEIRNPIHAIGLLIREMDYETEVEMEKGFNPAQPLNIRMNLTQLYGSNTAGYIVCRGVHKIASTRFLICRDLLILQQLLMRLGDAVIWGTGQLFQAQQDLLHRTAPLLLSYYLIKWGSECLATDVPLDTLESNLQHLSVLELTDSGALMANRFVSSPQTIVELFFQEVARKHIISHLFSQPKAPLSQTGLNWPEMITAITSYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHPWCQVNVGSCRFMLGRCYLVTGEGQKALECFCQAASEVGKEEFLDRLIRSEDGEIVSTPRLQYYDKVLRLLDVIGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEALTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNYYELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQGNCYLAALNCLRLIRPEYAWIVQPVSGAVYDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKECSLARIRLTLAQHDPSAVAVAGSSSAEEMVTLLVQAGLFDTAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAAQAEAWAWLAANQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVPLPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAPMVWLPYSSIDQLLQALGENSANSHNIALSQKILDKLEDYQQKVDKATRDLLYRRTL
Protein: Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) (O13651)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative leucine--tRNA ligase, cytoplasmic
- Putative proline--tRNA ligase C19C7.06
- Probable glutamate--tRNA ligase, cytoplasmic
- Probable glutamine--tRNA ligase
- Probable methionine--tRNA ligase, cytoplasmic
- Probable proline--tRNA ligase, mitochondrial
- Lysine--tRNA ligase, cytoplasmic
- Glutamate--tRNA ligase, mitochondrial
- Probable arginine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, mitochondrial
Sequence:
MSFNVPKEEEKIVEFWREIDAFHTQLKLSQGRPTYTFFDGPPFATGRPHHGHLLASTIKDSVTRYACLKGYHVERRFGWDTHGLPVEHEIDKKLGITGSDDVMAMGIDKYNAECRKIVMTYASEWRATVERLGRWIDFDNDYKTLYPSFMESVWWVFKELHTKGKVYRGYRVMPYSTACTTPLSNFEAQQNYKEVPDPAIVVAFQSISDPEVSFLAWTTTPWTLPSNLALAVHPDLQYIKILDKDSNKKYILMESCLGILYKNPKKANFEILERFQGKALDGQKYEPLFPYFKSTFGERAFKLYSADYVEEGSGTGIVHQAPAFGEADYDAAWAAGIIDADHQPPCPVDEQGLLTSEITDFAGQYVKDADKEIIRSLKASGHLVKHSQIFHSYPFCWRSDTPLIYRAVPSWFVRVKEITNEMVENVMSTHWVPQNIRDKRFANWLKNARDWNISRNRYWGTPIPLWVSDDYEEVVCIGSIKELEELSGVSNITDIHRDSIDHITIPSKKGKGTLHRVSEVFDCWFESGSMPYASRHYPFERIEEFKHGFPADFISEGVDQTRGWFYTLTVLGTLLFDKAPYKNVIVSGLVMAEDGKKMSKRLKNYPEPNLIIEKYGSDALRLYLINSPVVRAEILKFKEDGVREVVTRVLIPWWNSYKFFEAQAALYKKVTGKDFVFDDAATLSSNVMDRWILARCQSLIGFVDEEMKQYRLYTVVPQLLGLIEEMTNWYIRFNRRRLKGEDGEIETINALNVLFEVLFTLVRIMGPFTPFITENIYQHLRNYMPIDKNEISLRSVHFLPFPTYKSELDDETVLRRVKRMQTIIELARYVREQNNISLKTPLKTLIVILTNEEYLEDAKLLERYIAEELNVREVVFTSNEEKYGVVYSVQADWPVLGKKLRKDMARVKKALPNVTSEEVKEFQKNKKMVLDGIELVEGDLQIIRSVEVKNEFLKSNTDGICIVLLDIEIDAQLQAEGLAREVINRVQRLRKKSNLQVTDDVRMTYKIKNDTIGLESAVDSNEALFSKVLRRPIEKETGADESNIIASEEQDVQGATFLLSLLRL
Protein: Protein FAM193B (Q3U2K0)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Partly colocalized with an endoplasmic reticulum marker, HSP90B1. Shuttles between nucleus and cytoplasm (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MTRRRSRPSGGAGRRERARAAGLQKPQAPEPQPPPPSLEAGAGAGPPEVPAELDCDGPREEEEPKLAPGPQVPPTSSQSVQTCCLLCHRERKGWEEGPSQNGLVLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEEERQTGGDHAVAISLSHTSCKSQSCGGDSHSSSSSSSSSSSSSSSCHGNSGDWDPSSFLSAHKLSGLWNSPHSSGAVPGSSLGSPPAILGEAFPVSEHHQHSDLTAPPNSPTGPPPHPASLIPSHPGSFSSASYPPPLPTTPVAPFPAQASECPMAAATATHPSGPCQSPHPPSTSMPLLKMPPPLSGCSHPCSGHCSGHCGGPLLPPPSSQPLPSTHSRDPGCKGHKFAHSGLACEADEGLGEEEDSSSERSSCTSSSTHPRDGKFCDCCYCEFFGHNAPLAAPTSRNYTEIREKLRSRLTRRKEELPMKGGTLGGIPGEPAVDHRDVDELLEFINSTEPKVPNSARAAKRARHKLKKKEKEKARLATEALKQVNRVSGSQEPRPARERLLEWPDQELDRVNSFLSSRLQEIKSTVKDSLCASLSMCELSVESSGFKEGTVEAQTLTPSDLSGSSQKRPDINLDLSPLTLGSPQSHTLQAPSEPVPPWAERRDPHPPPWTEVRGPPPGIPENGLVRRLNTVPNLSRVIWVKTPKPGNPSSEESSKEVPSCKQELSEPVATGGKPKKSKRQGSQAKKTLASPAPWSPANLEASGAKSQVSSPKQPSKGSEPAKVGSGAEPGEGSPGSRPGPIQADSPKTDKKGSSWQNWPGGAKARTLEQESEQTPGPARPQSLSQGKGRSRRSRNKQEKSASSLDDVFLPKDLDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ
Protein: Keratin 77 (Q0IIN1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSHQFSSQSAFSSMSRRVYSTSSSAGSGGGSPAVGSVCYARGRCGGGGYGIHGRGFGSRSLYNLGGSRSISINLMGRSTSGFCQGGGVGGFGGGRGFGVGSTGAGGFGGGGFGGAGFGTSNFGLGGFGPYCPPGGIQEVTINQSLLEPLHLEVDPEIQRIKTQEREQIMVLNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTGTNNLEPLLENYIGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQTHISDTNVILSMDNNRSLDLDSIIDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQRLQAEISNVKKQIEQMQSLISDAEERGEQALQDAWQKLQDLEEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLLEGEESRMSGELQSHVSISVQNSQVSVNGGAGGGGSYGSGGYGGGSGGGYGGGRSYRGGGARGGSGGGYGSGCGGGGGSYGGSGRSGRGSSRVQIIQTSTNTSHRRILE
Protein: WASH complex subunit 5 (WASH complex subunit strumpellin) (F1M1B3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- WASH complex subunit 4
- WASH complex subunit 2
- WASH complex subunit 1
- WASH complex subunit 3
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha-1
- Vacuolar protein sorting-associated protein 35
- Sorting nexin-27
- TBC1 domain family member 23
- Coiled-coil domain-containing protein 93
Sequence:
MLDFLAENNLCGQAILRIVSCGNAIIAEVLRLSEFIPAVFLLKDRADQQRYGDIIFDFSYFKGPEFWESKLEARPELQDLDEEFRENNIEIVTRFYLAFQSVHKYIVDLNRYLDDLNEGVYIQQTLETVLLNEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVSYYRYSAARSSADSNLDDICKLLRSTGYSSQPGAKRPPSYPESYFQRVPINPTFISMAIGRLRSDDIYNQVSAYPLPEHRSTALANQAAMLYVILYFEPSILHTHQAKMREIVDKYFPDNWVISIYMGITVNLADAWEPYKAAKTALNNTLDLPNVKEQASRYASVSERVRAQVQQFLKEGYLREEVLLDNIPRLLNCLRDCNVAIRWLMLHTADSACDPNNKRLRQIKDQILADSRYNPKILFQLLLDTAQFEFILKEMFKQMLSEKQSKWEHYKKEGSERMIELADVFSGVKPLTRVEKNENLQAWFREISKQILSLNYDDSTAAGRKTVQLIQALEEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITMQIVGDLSFAWQLIDSFTSIMQESIRVNPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVSYVRKVLQIIPESMFTSLLKIIKLQTHDIIEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVKRVAFALHRGLIFNPRAKPSELMPKLKELGATMDGFHRSFEYIQDYVNIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSIYQSTHIPIPKFAPVDESITFIGRLCREILRITDPKVTCYIDQLNTWYDMKTRQEVTSSRLFSEIQTTLGTFGLNGLDRLLCFMINFLSMFQKIILRERTVQETLKTLMNAVSPLRSIVANSSKVYLAAITKTQKIWSTYLEAIMKVGQMQILRRQIANELNSSCRFDSRHLAAALDNLNKALLADIEAHYRDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPADPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFIRSTMEQCTSQKMPEMPADAVGALLFLEDYVRYTKLPRRVAEAHVPNFIFDEFRTVL
Protein: NRAMP-like transporter smf-2 (Divalent metal transporter smf-2) (Q21433)
Organism: Caenorhabditis elegans
Function: Probable divalent metal ion transporter which regulates Mn(2+) uptake.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:19924247}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:19924247}. Note=Predominantly localizes in cytoplasmic vesicles in epithelial cells. {ECO:0000269|PubMed:19924247}.
Interaction partners:
- NRAMP-like transporter smf-3
- NRAMP-like transporter smf-1
- Probable small nuclear ribonucleoprotein F
- Solute carrier family 40 member
- Solute carrier family 40 member
- Ferritin
Sequence:
MPGFQNANISDLAPPAREKTFDDTIAVKIPEDEKNTWFSWRKLWAFTGPGFLMSIAYLDPGNIESDLQAGAQAEYKLLWVLLVSHIVGMLLQRMSARLGVVSGKHMAEIAYDYYPLVPRIILWLMIEIAIVCSDMQEVIGTAIAIYLLSSGKIPLLVGVLITILDTFTFLFIDRYGIRKLEFIFVALISTMAISFGYEFVVMKPVLTKVLTGTVVPWCSGCGKEEIITAISIFGAVIMPHNFYLHSALVKSRKVDRSSKTRIAEANKYFSIESAFALSVSFFINLFVLSVFARGLYQKTNGDVNSMCLSHNDIPDSNVFPNNTSSVTVDLFQGGIYLGCQFGLFAMIIWAIGIFAAGQSSTMTGTYTGQFVMEGFVRISWPKWKRVLITRAVAITPTLILCIKAHGIKNLTGMNDFLNCVQMVQLPFALIPMITFTSSKRIMHNFRTSKPLQYFSIICGIITIGINVYFIFQYVTENFGTGWLIFVIIGPFTLLYIAFILYLAIYCLVACELMNDTVNLPGFDFHRTLELDAPWITETFVVNDVYF
Protein: Transmembrane protein 45A (DNA polymerase-transactivated protein 4) (Dermal papilla-derived protein 7) (Q9NWC5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase MINDY-3
- Growth hormone-inducible transmembrane protein
- COP9 signalosome complex subunit 7a
- Proton-transporting V-type ATPase complex assembly regulator TMEM9
Sequence:
MGNFRGHALPGTFFFIIGLWWCTKSILKYICKKQKRTCYLGSKTLFYRLEILEGITIVGMALTGMAGEQFIPGGPHLMLYDYKQGHWNQLLGWHHFTMYFFFGLLGVADILCFTISSLPVSLTKLMLSNALFVEAFIFYNHTHGREMLDIFVHQLLVLVVFLTGLVAFLEFLVRNNVLLELLRSSLILLQGSWFFQIGFVLYPPSGGPAWDLMDHENILFLTICFCWHYAVTIVIVGMNYAFITWLVKSRLKRLCSSEVGLLKNAEREQESEEEM
Protein: Uncharacterized protein (Q580K2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDYTDIYLRPRKKESVSPQEPLRSAQVDSAAESRVEWMLKGAFSVQQLLDRVEELSARVCMFDEKMVNLTKLVKLAQGIQEEKEADIRFQQQELLSRLKRLEQACARLEDMETFKQFIISKVQETLEDAHQAFLSDLAKIRADGEEQAARTKQRIENTVSDVRRDVEERIASLWGEAEQKDLSRQEAQDTLREKLRLVESSLRDLEMSVGRDYSRVPPLQEKIDGITQSLSSLEQKVDKTAGTVVTLGNEAKQARALLMEEIETTRQWVTRNLQRVKQHVEVISSDVEQLHNGRADLSARISRISCQADMECKKLRSQLSQKALVADALDNLVQKEFYKVEDVALRHQSLRTEVGAVKDV
Protein: Zn(II)2Cys6 transcription factor (Eurofung) (Q5B0X2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MSSSPERDREGILDSTSASLNELINKKRSNSEATEYPRRRATIACQICRLRKTRCNGARPKCQLCTDLDAECVYREPGIKLDAGDKLIIERLARIEGLLQTSLAAQNSQLTLSSTSPATSNGTNVGSDDTVAKASTHLAVTGRTTSIVGLASWANPPTSISTMPRVHTTPALNLLKWPLIRDLVARPYDSQTLLQLEMAREPLKMTPPMAVDLSCAPLYIRTFFEKVNVWYACVNPYTWSKYYDAAVSLSFREGPESCVVLLVLALGCAAQCGSIALISTDRDPPGVPYFIAAWNLLPSVMMRNSVVAAQCIILAAAYLFYLVRPLEAWTLLSNASMKLQLLFGNPSRVPVQWRELSVRVYWNALLYESDLLAELDLPHSGIVNFEELVDLPGGFDEIEDDEDEDDGDTGNKLVSPIGCDELWYFLAEIALRRLLNRVSHMLYQKDNSLTLASLAPIVSELDFQLSQWYEGLPQPVRFPLSHAPISHPVQTVLRLRYFACRTIIYRPYILAVFENEQASGDSWVRECCRRCLEATLYQLESVTTHREGHLPYLWQGALSMVSQSLLIMGATMSPALSSLLPPTLRVDEIISSVIVEVDRYAHLAPSLKLSSEILRDAERRRQICLRSSGSRV
Protein: Ubiquitin-conjugating enzyme E2 14 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 14) (Ubiquitin carrier protein 14) (Ubiquitin-protein ligase 14) (Q9UTN8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.
Interaction partners:
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit cut9
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 2
- Ubiquitin-conjugating enzyme E2-20 kDa
- Anaphase-promoting complex subunit 3
Sequence:
MASASPSSSRRLTKEYSDLREHPIPDIRVNLVDDNLFHWACTALGPSDSVYAGGKFHFSLKFPLDYPFQPPTIEFTTRIYHPNFDSEGNVCLAILKQQVFKPSIKLRSVLEQILQLLREPNPDDPLVASIAEQYRNDRPSFDKIARDYVEQFAKS
Protein: Iodotyrosine deiodinase (EC 1.21.1.1) (Halotyrosine dehalogenase) (F4KU78)
Organism: Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)
Function: Catalyzes the dehalogenation of halotyrosines such as 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity). Activity towards 3-iodo-L-tyrosine is much stronger than activity towards 3,5-diiodo-L-tyrosine and 2-iodophenol.
Interaction partners:
Sequence:
MKQKPAFIPYAGAQFEPEEMLSKSAEYYQFMDHRRTVREFSNRAIPLEVIENIVMTASTAPSGAHKQPWTFVVVSDPQIKAKIRQAAEKEEFESYNGRMSNEWLEDLQPFGTDWHKPFLEIAPYLIVVFRKAYDVLPDGTQRKNYYVQESVGIACGFLLAAIHQAGLVALTHTPSPMNFLQKILQRPENERPFLLVPVGYPAEGAMVPDLQRKDKAAVMVVY
Protein: T31J12.3 protein (Q9ZPZ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT3g07470/F21O3_18
- Late embryogenesis abundant protein-related / LEA protein-like protein
- At2g01610
- Uncharacterized protein
Sequence:
MGLVTEEVRAKAEMYTGDEICREKTKCFLKEISMPNGLLPLKDIEEVGYDRESGVVWLKQKKSITHKFTEIDKLVSYGTEVTAIVETGKIKKLTGVKAKELLIWVTINEIYTEEPPTKITFKTPTTLSRTFPVTAFIVPEEPAKEEPAKEEPAKEKSSEATEAKEAVAIKEAVAVKEAA
Protein: Lute, isoform D (A0A0B4KGU2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MASSSNNSSSTANNHGGHNPLNRLSLKSAGKRNQESMSHSQPNGGWINVETLNNGNGLLHSPPHNHQQQQQQQQRGGGGASPAGGGGGPSAAADHNIQITQPISAPSSPLASPGALNSSGSSSGGGAGSAGGISGSPTAFCLPSSSAAAAVAAISATPTSGSGSYVCSAGTNWHFAAVAASNAIDTADPNWQASKATVLERNAAMFNNELMSDVKFIVGGEFDIDPIQTIPAHKYILATGSSVFYAMFYGGLAENKQEIKVPDVEPTAFLTLLRYLYCDEIKLEPEHILATLYAAKKYIVPHLARACVNYLEVKLTAKNACLLLSQSRLFEEPELMQRCWEVIDAQAEMAVKSEDFVDIDLKTFESILSRETLNCKEIHLFEAALNWAMNACEKMSIDDTPQNKRRLLGQALHLIRIPTMSLEEFANGVAQTGILSSQETIDMFLHFTAKMKPSLGFPTRSRAGLKTQVCHRFQSCAYRSNQWRYRGRCDSIQFSVDRRIFIVGFGLYGSSTGAANYNVKIELKRLGRTLAENDTKFFSDGSSNTFHVFFENPIQIEPECYYTASVILDGNELSFFGQEGMSEVLMGNVTFQFQCSSESTNGTGVQGGQIPELIFYGPTTVTAMSSPTNSLCPTPIGGSSSNAGATSTAAAGTAVPNSSNGSGNNANSSGEDGDGSTXCAQLYCAEWQGACYYRQQQQQQRRPTQQYKTQQPQKIQIQNRNSWVFSAAQESKLEF
Protein: BOS complex subunit TMEM147 (Transmembrane protein 147) (I6VSD2)
Organism: Capra hircus (Goat)
Function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BVK8}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q9BVK8}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27337943}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Nicalin
- PAT complex subunit CCDC47
- Mechanosensitive cation channel TMEM63A
- Calcium load-activated calcium channel
- SEC61 translocon subunit alpha 2
- Aldose 1-epimerase
- PAT complex subunit Asterix
- Transmembrane protein 223
- Transmembrane protein 53
- Large ribosomal subunit protein uL2
Sequence:
MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTYRPAVLLLMFLSVYKAFVMETFVHLCSLGSWTALLARALVTGLLALSTLALYVAVVNVHS
Protein: DNA replication licensing factor MCM4 (EC 3.6.4.12) (E5RG31)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
Sequence:
DMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL
Protein: cDNA FLJ60065, highly similar to Solute carrier family 12 member 4 (B4DF30)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKECLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFEYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
Protein: Mitogen-activated protein kinase KSS1 (MAP kinase KSS1) (EC 2.7.11.24) (Kinase suppressor of SST2) (P14681)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Together with closely related FUS3, KSS1 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively. Phosphorylated KSS1 activates both pathways, whereas activated FUS3 activates the mating but suppresses the filamentation pathway. KSS1 activity is down-regulated by FUS3 during pheromone induction to prevent inappropriate activation of the filamentation pathway. During induction of filamentation, KSS1 activates the transcription factor STE12 resulting in its binding to and activation of filamentation specific genes. Non-activated KSS1 has a kinase-independent repressive effect on STE12 transcriptional activity, that is mediated by direct binding to STE12 and depends on the presence of DIG1 and DIG2, and that is required for the suppression of filamentation under normal growth conditions. SSN3/SRB10 contributes further to the suppression of filamentation under these conditions by reducing STE12 stability independent of KSS1. FUS3 can partially compensate for the lack of KSS1 but filamentation becomes constitutively induced at a low level in the absence of any signal. KSS1 phosphorylates STE7, STE5, FAR1, DIG1, DIG2, STE12, and SST2.
Subcellular location: Nucleus {ECO:0000269|PubMed:11781566}. Cytoplasm {ECO:0000269|PubMed:11781566}. Periplasm {ECO:0000269|PubMed:11781566}. Note=KSS1 shuttles rapidly between the cytoplasm and the nucleus independent of its activation state.
Interaction partners:
- Protein STE12
- Down-regulator of invasive growth 1
- Down-regulator of invasive growth 2
- Serine/threonine-protein kinase STE7
- Protein STE5
- Tyrosine-protein phosphatase MSG5
- Mitogen-activated protein kinase FUS3
- Cyclin-dependent kinase inhibitor FAR1
- Ty transcription activator TEC1
- Tyrosine-protein phosphatase 3
Sequence:
MARTITFDIPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRYFHEHENIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIKSKRAKEYIANLPMRPPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRISAAEALRHPYLAMYHDPSDEPEYPPLNLDDEFWKLDNKIMRPEEEEEVPIEMLKDMLYDELMKTME
Protein: Protein CUP-SHAPED COTYLEDON 1 (NAC domain-containing protein 1) (NAC domain-containing protein 54) (ANAC054) (NAC domain-containing protein CUC1) (Q9FRV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Seems to act as an inhibitor of cell division.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:15500463}.
Interaction partners:
- Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 4
- Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 3
- Protein WUSCHEL
- Homeobox protein knotted-1-like 6
- Ethylene-responsive transcription factor ESR2
- Protein ASYMMETRIC LEAVES 2
- Transcription factor AS1
- Zinc finger protein JAGGED
- Floral homeotic protein APETALA 2
- Homeobox protein knotted-1-like 2
Sequence:
MDVDVFNGWGRPRFEDESLMPPGFRFHPTDEELITYYLLKKVLDSNFSCAAISQVDLNKSEPWELPEKAKMGEKEWYFFTLRDRKYPTGLRTNRATEAGYWKATGKDREIKSSKTKSLLGMKKTLVFYKGRAPKGEKSCWVMHEYRLDGKFSYHYISSSAKDEWVLCKVCLKSGVVSRETNLISSSSSSAVTGEFSSAGSAIAPIINTFATEHVSCFSNNSAAHTDASFHTFLPAPPPSLPPRQPRHVGDGVAFGQFLDLGSSGQIDFDAAAAAFFPNLPSLPPTVLPPPPSFAMYGGGSPAVSVWPFTL
Protein: Stripe b protein (Q24163)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MIMEGLETLVAPTHHAFLLTETAAAAHFNVLSFDTCLFKTSTAAQSSGSPSTATYLSPAQFGGSHHGGASTSSNSLNSSSTASSSSTSSSLLHYTTASAAAAAAAAAAASANNSVLRARNQTATPTQGGSPGHVAVQPSATASSGRSSASHLSLLNTSGQHSPTSSAVEQVEAHKQLIEALPGDLNTPVTTSSDIPSFFGPTTVVEPPPITGSIESEDLSLEPQVISVASPVLSHCSPLKEERSTPPALAIVKEESSNNSCNMYPQHNNNNNNNNNTTSSSTTTTSKQTTSESNTECVGSPGNHTQSHQQQQQQLQHNNTSSSNSNCHHSHQQQQQQQQQQHMSSPQQQYQQHQILHQQQQFGYHHHHHHHHHHHHSQLQQLQQQQQQQQQQQQHQQQPLHQQQQLQHQQQQQHHQQHYQQHAIQHQQSQQQASKISYRGIFTTTGNAMNAAAAAAAAAAQQQHQQQQQHQQQLPSPQLGVLAGPMSPPSNSLGNSWGLPSPDKTMFQPPLFSLPAHYATMQQQQQQQQQQQQQQQQQQAAGAAPSPYDDGRAAAAAAAQHAELLGLTMDCTPLLLKQPPPSYAGASAGFPGLGDLHSSHEQQLQQQQYVRSQPKYQWLDSPADYAQQQQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGVLIPKQENYPDMQPSSNGTGYSGGSGGSSAAAAAAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQSTVPLKLVPVKPRKYPNRPSKTPVHERPYACPVENCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFSCDICGRKFARSDEKKRHAKVHLKQRIKKEKVRGEQQQQQQQQQQQQQQQQQQQLQQQQEQHHLSLQQHQQYQQHHLLHSADLAIVTSSASM
Protein: Regulator of Ty1 transposition protein 105 (P40063)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in regulation of Ty1 transposition. Inhibits Ty1 transposition at a post-transcriptional and pre-integrational stage of the Ty1 retrotransposition cycle.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Replication factor A protein 3
Sequence:
MYSNHNLNSDDCCFDWNEEKAAELQRTGVSFDRSLTPQSLRTSTRRLSEENKQQSGTMHIDTSPSVVSDIISSRRDRSQDFFGPHSSSPIAPSERQRADQRSRLESMRLTRRRDKMTKVRGGLEKMEEMIMQGEHLREMQRLKQEAQKNALPSDMAEYMEWQNNEDLEDDELLAFIEKQETYKNELEHFLNNANKNVYENNSYPNSHT
Protein: FCS-Like Zinc finger 16 (Q4PSK3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:29945970}.
Interaction partners:
- FCS-Like Zinc finger 17
- FCS-Like Zinc finger 12
- FCS-Like Zinc finger 15
- FCS-Like Zinc finger 5
- FCS-Like Zinc finger 6
- FCS-Like Zinc finger 3
- FCS-Like Zinc finger 1
- FCS-Like Zinc finger 2
- FCS-Like Zinc finger 11
- Protein INCREASED RESISTANCE TO MYZUS PERSICAE 1
Sequence:
MANIMIPSKRPRAPSFSEKHPKYVGSSDWLPAEKDKAQVQLTNFLELCRFCKKNLRHDEDVFMYGYLGAFCSKQCRAKQMACDVFRDFSRQKANVKKGRTSKDEGLDRISSSPSSSSSSSCFYI