wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5) (Q63008)
Organism: Rattus norvegicus (Rat)
Function: Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland. Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:36517601, ECO:0000269|PubMed:9341168}; Multi-pass membrane protein {ECO:0000269|PubMed:36517601}. Cytoplasm {ECO:0000250|UniProtKB:Q92911}.
Interaction partners:
- Thyroglobulin
- Thyrotropin receptor
- Thyroid peroxidase
- Pendrin
- Paired box protein Pax-8
- Iodotyrosine deiodinase 1
- Monocarboxylate transporter 8
- Forkhead box E1.
- Homeobox protein Nkx-2.1
- Dual oxidase 2
Sequence:
MEGAEAGARATFGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQNHSRINLMDFDPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRYVACHTEGKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRKLVFISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCTNDSVLLGPPGATNASNGIPSSGMDTGRPALADTFYAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTATLEESLVKGPEDIPAVTKKPPGLKPGAETHPLYLGHDVETNL
Protein: Tyrosine-protein kinase receptor svh-2 (EC 2.7.10.1) (Met/Ron-like receptor tyrosine kinase svh-2) (Suppressor of vhp-1 deletion lethality protein svh-2) (H2KZU7)
Organism: Caenorhabditis elegans
Function: Receptor tyrosine kinase which may phosphorylate mlk-1, a component of the mlk-1, mek-1 and kgb-1 pathway. Involved in axon regeneration after injury by promoting the generation of productive and stable growth cones.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Serine protease svh-1
- Sex muscle abnormal protein 5
- Protein let-756
- Tyrosine-protein phosphatase vhp-1
- Transcription factor ets-4
- Mitogen-activated protein kinase kinase kinase mlk-1
- CCAAT/enhancer-binding protein homolog 1
- SHC-transforming protein homolog 1
- Fatty acid amide hydrolase 1
Sequence:
MVLGSSQSSAKELTTQSSIFRFLVLLLCFTSATGGQINGKLLNGNGVFVSRDELQNKNVLGVITGFDLLVVATHSRFQVFENNEERRTVGHVSLDMHPRTKFLELKLFSKSEIFYCDESSCGLCTYSGVTSSCSTFMLNGDEPKIQEILSSSAVKIENLGQIMLAISFKNEEDPDNPRTMILRYNAQDTGTVIPTAYHADSSFIHNNHALTGFEREGFVYFVMTASQIFEPEVFLHDQSNNKVTVTKVIRFCATDQTADLASKISILVGCDQEFRNISSRGETAVYDHANDLINIVMFNHTSMNHLMCRFKMANIEKRFKTIWSTCQETSFSGSTAKTTRCKYPQIFDQMKVKKGCLTYSRLDDESSPTLCVRYGRGDALDNCQLHTAKSNSYRYGWLEDYNVLQGELMMRIPYPFFGIAESLITDGKSYFAAVSGEFDMSDVLRFSASESADIRPHWRTNISVVGKFSITKTKENQLLYTTVEGLQSLDISCKGLYPNCQTLRQGGWEDPLECSWCADDNAQRTITSSEVSSCKNNLKHECPPSMRWIHKYNNNSGFTAVVDGFRALKNPKLNACGTNCVVTVVDSSSIQCDTNPDEVIGDSCKQVFLSGMIGDKNYSFPFDYQQADRGTQTDVKNSQVDDKKGSSPGWKIAIAIISVMTIILIVAIIVYYMRNRFPRIKTHVRPPIGQRIENEYDMGHMAGRQAQLAINGDNYVKVFRSMRPDLKVDFKNLRVDKLDPIGQGHYGVVYKAMYSPSKSLEEKVVCKYLKEGKISEFYEEARTMSEFDHPNILKLIGVALDDSSHLPIIITEYMAKGDLKSFIENVENTIKMRDLFEFAFDIAKGMNYMHSKKFIHRDLACRNCLLDEHLRVKIADFGLCRKVDIETELYVQMHERDLPVRWFPPEISEQGFGITSDIWSFGVVIWELFTRGSTPYSNMASWILILPWLKESETNRLRKPPYCPEKLYTDVMLACWKANPAERPQFSDLVTIIPNVVKYMEGYDRSQLQAGYERVSSRFLSLSRHDPAFPIYQNEMPNTPLLANCQNDTNDSKTLAELPSDSPSTSTAIPQSTPYQLLSECSETSV
Protein: T. brucei spp.-specific protein (Q381V5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPSESLADVDCKINEMRDRLMNISQCLQRDEEFDAGFVPGRSPEVYQQDERNSIVSHAADEELPRKRQTSISSSAERIFTKEEKLSVLREEAGDGNIKTLNTSRRKGSTTALVEEVEMCDSGIKEQESIKTTYQLGAPYTKNNNINGGPPQAGVLQAERQVHVSSSQPLTHLVGGSFDPLQAMEIRLREKLRKKVSSSNHPSDTVGSVNNLPVEQRNISNSAAENSPLHEPWTATAETPSNKTQGPVRESSEKQYKQYVDKGCGSCALDTEYLCAGEDKRPTVRSSSVVTEVSRPLVSRGSCQHRVQGTNFMRPIFARAPHSPGSPRVTEKSVSCKNTIRGNSGPRGRTPSQVGGDPVRPVLPRKTAPQRTVLDILTGAELFALLRLRGVIVSRGDTGEYLLPEARCHSVYLSPEEHRQLLDLRTKLRAQCSRNPVEPRIRGSPMQQRAESGPTRRTGQMHRTSELQCNLRQR
Protein: At1g58420 (Q9C647)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F13M7.16 protein
- AT1G10660 protein
- S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase, chloroplastic
- Calcium-dependent protein kinase 28
- Actin-related protein 5
- L-type lectin-domain containing receptor kinase I.9
Sequence:
MGKRGQKQNRFLRIVTMPLKVLCKARDLYMRSITGCAARTHYSSAVDAASVPFPRSRSTSSAFSSSASSRRRSSDFTFDDDYSELLRAASVRSLGHKNEIDMIIQQQQQQQQQRQENRVAMGAVTVKGGLPKSSSVGMTMARIDEEDEEEGSVKNQKKGSDFLYPRSRSHAVTIRGSKF
Protein: Probable copper-transporting ATPase HMA5 (EC 7.2.2.8) (Probable copper-transporting ATPase 3) (Protein HEAVY METAL ATPASE 5) (Q9SH30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in copper import into the cell. May play a role in copper detoxification in roots.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Copper chaperone for superoxide dismutase, chloroplastic/cytosolic
- Copper transport protein ATX1
- Zinc transporter ZTP29
- Copper transporter 5
- At5g23760
- Copper transporter 1
- Copper transporter 2
- Cytochrome c oxidase copper chaperone 1
- Copper transport protein CCH
- Metal tolerance protein 1
Sequence:
MATKLLSLTCIRKERFSERYPLVRKHLTRSRDGGGGSSSETAAFEIDDPISRAVFQVLGMTCSACAGSVEKAIKRLPGIHDAVIDALNNRAQILFYPNSVDVETIRETIEDAGFEASLIENEANERSRQVCRIRINGMTCTSCSSTIERVLQSVNGVQRAHVALAIEEAEIHYDPRLSSYDRLLEEIENAGFEAVLISTGEDVSKIDLKIDGELTDESMKVIERSLEALPGVQSVEISHGTDKISVLYKPDVTGPRNFIQVIESTVFGHSGHIKATIFSEGGVGRESQKQGEIKQYYKSFLWSLVFTVPVFLTAMVFMYIPGIKDLLMFKVINMLTVGEIIRCVLATPVQFVIGWRFYTGSYKALRRGSANMDVLIALGTNAAYFYSLYTVLRAATSPDFKGVDFFETSAMLISFIILGKYLEVMAKGKTSQAIAKLMNLAPDTAILLSLDKEGNVTGEEEIDGRLIQKNDVIKIVPGAKVASDGYVIWGQSHVNESMITGEARPVAKRKGDTVIGGTLNENGVLHVKVTRVGSESALAQIVRLVESAQLAKAPVQKLADRISKFFVPLVIFLSFSTWLAWFLAGKLHWYPESWIPSSMDSFELALQFGISVMVIACPCALGLATPTAVMVGTGVGASQGVLIKGGQALERAHKVNCIVFDKTGTLTMGKPVVVKTKLLKNMVLREFYELVAATEVNSEHPLAKAIVEYAKKFRDDEENPAWPEACDFVSITGKGVKATVKGREIMVGNKNLMNDHKVIIPDDAEELLADSEDMAQTGILVSINSELIGVLSVSDPLKPSAREAISILKSMNIKSIMVTGDNWGTANSIAREVGIDSVIAEAKPEQKAEKVKELQAAGHVVAMVGDGINDSPALVAADVGMAIGAGTDIAIEAADIVLMKSNLEDVITAIDLSRKTFSRIRLNYVWALGYNLMGIPIAAGVLFPGTRFRLPPWIAGAAMAASSVSVVCCSLLLKNYKRPKKLDHLEIREIQVERV
Protein: Calcineurin subunit B type 2 (Protein phosphatase 2B regulatory subunit 2) (Protein phosphatase 3 regulatory subunit B beta isoform) (Q63811)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Subcellular location: Mitochondrion {ECO:0000305|PubMed:34446558}. Note=Localizes in the mitochondria in a SPATA33-dependent manner. {ECO:0000305|PubMed:34446558}.
Interaction partners:
- Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
- Protein phosphatase 3 catalytic subunit alpha
- Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
- Calcineurin subunit B type 1
- Nuclear factor of activated T-cells, cytoplasmic 3
- Nuclear factor of activated T-cells, cytoplasmic 1
- Nuclear factor of activated T-cells, cytoplasmic 2
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Nuclear factor of activated T-cells, cytoplasmic 4
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Sequence:
MGNEASYQTELCNHFDQEEIRRLGKSFRKLDLDKSGSLSIEEFMRLPELQQNPLVGRVIDIFDTDGNGEVDFHEFIVGTSQFSVKGDEEQKLRFAFRIYDMDNDGFISNGELFQVLKMMVGNNLKDWQLQQLVDKSILVLDKDGDGRISFEEFSDVVKTMEIHKKLVVFVEHGQEDLKA
Protein: DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) (P48011)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase III subunit rpc8
- DNA-directed RNA polymerase I subunit rpa43
- DNA-directed RNA polymerase I subunit RPA12
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase I subunit rpa1
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit rpb4
Sequence:
MNHPTSTGGTAFNPPRPATMIYLCADCGARNTIQAKEVIRCRECGHRVMYKMRTKRMVQFEAR
Protein: Uncharacterized protein (Q9I328)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR017117}.
Interaction partners:
- Type III secretion chaperone SycN
- Type III secretion system effector delivery regulator TyeA domain-containing protein
- Type III secretion outer membrane protein PopN
- Uncharacterized protein
- Type III secretory apparatus protein PcrD
- Translocation protein in type III secretion
- Translocation protein in type III secretion
- Translocation protein in type III secretion
- Transcriptional regulator protein PcrR
- Type III secretion protein PcrV
Sequence:
MTLKPTQQRLLLMLGWLHLQCGQPRRAQVLLEALLSVAPERRDGRRALLLALLQQGLGEPAVRLCRQLQEDGEEEPGLWRCLSRAEQLAGRLDAARAAHARALELEARE
Protein: Ubiquitin-conjugating enzyme E2-17 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D1) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) (P25867)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Required for proper telomere behavior during cell divisions and possibly for ubiquitination of proteins involved in postmeiotic stages of spermatogenesis. Deletion mutations are lethal in homozygotes.
Interaction partners:
- Cullin homolog 1
- Ubiquitin-ribosomal protein eL40 fusion protein
- RING-box protein 1A
- E1 ubiquitin-activating enzyme
- GEO06356p1
- Ubiquitin thioesterase otubain-like
- Supernumerary limbs, isoform B
- E3 ubiquitin-protein ligase sina
- Ubiquitin-ribosomal protein eS31 fusion protein
- E3 ubiquitin-protein ligase CHIP
Sequence:
MALKRINKELQDLGRDPPAQCSAGPVGDDLFHWQATIMGPPDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNELAREWTRKYAM
Protein: Cation-dependent mannose-6-phosphate receptor precursor (MPR46) (Mannose-6-phosphate receptor (cation-dependent)) (Q6P032)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
- Cation-independent mannose 6-phosphate receptor
- Golgi-associated, gamma adaptin ear-containing, ARF-binding protein 3a.
- ADP-ribosylation factor-binding protein GGA3 isoform X1
Sequence:
MLLSVRIITPLFVLFAGVQARFNTSNCKLVSDSESQRKALRLLEPLTNQNFTTEGQEKEKYSYIFQVCGDAGGVKNAGLIQQEKGGKTIRIGDYSKTVATAGSDWVLLIYEGGEKYDSHCSSEERKAMIMISCSSSSKSAFSVVMEENQKQKNCYYLFELDTTAVCPAVSSKLSAGSIVLIVVISSLTVYIIGGFLYQRLVVGAKGVEQFPNFAFWSEIGNLSADGCDFVCRSRGNREEPPTYRGVGTEPLGEEPEERDDHLLPM
Protein: High-osmolarity-induced transcription protein 1 (Q03213)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for a complete transcriptional response to osmotic stress, through recruitment of HOG1 followed by pol II recruitment to the promoters of GPD1 and other HOG-dependent genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:10409737, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Mitogen-activated protein kinase HOG1
- Transcription factor SMP1
- CRE-binding bZIP protein SKO1
- Zinc finger protein MSN2
- Zinc finger protein MSN4
- Casein kinase II subunit beta'
- Casein kinase II subunit beta
- Sugar transporter STL1
- Casein kinase II subunit alpha
- Casein kinase II subunit alpha'
Sequence:
MSGMGIAILCIVRTKIYRITISFDYSTLMSPFFLFLMMPTTLKDGYRMNSQVNEDAIGINLDLSLPTHISPTTGSESASGSNASTLRNDGNALDGGLLRTSAAISAPTGTSQPTETIGEKLSNEERVNSNVSASNSTTAGTGRMLSQSLTNDSPSNEISTDQLKIFQRMDEMSARMIEMEESFNKLSNKIAEQNTMVLNLKQDNYKVMNKLNILLKLVAQPSARPSTNNAQNKLAIELLNSISAVSSAYLQKMQNNGSGRQHTADLCTGDSNTHSGINQHRTTNGTIDVNTNTAQLNNQFSNALNTILPDQQHNRNNVSQNINQSLPNRQLGPVINTQANQNQSQVLIHNTNTHQQVNRSPISFPNASTDKPFKLNPNGIKRRRRNTQSNNNASTNDHASAAQKPISALSPLTNSHNSTTSMNYTNSSIHSGVTSASNSFHDLNSLNNFGTTTALSLPSLALDNASFPPNQNVIPPIINNTQQPLSFSQLINQDSTTSELLPSGKSGVNTNIVNRNRASTLPSYPKPMTVKSNVDDDGYQEDDDDDGDDEGDGRDNEEDSTAEEDEVDDEIETDMKNASINKRRRSLHHKKSNSLNGRRKLHGESATKPNINSDLHYRILKAPTDVKTIWEEYDTGIRGKPSIKHLEAKYGNKWRLNKNKKTFSRRKRLYKFILNGMERGKTAQEMIETLENKRLYKDDEDGEVKKRTIGWLQESLAGI
Protein: Nuclear pore-associated protein 1 (Q9NZP6)
Organism: Homo sapiens (Human)
Function: May be involved in spermatogenesis.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:22694955}. Nucleus inner membrane {ECO:0000269|PubMed:22694955}. Note=Colocalizes with the NPC and nuclear lamins at the nuclear periphery.
Interaction partners:
- MAGE-like protein 2
- Small nuclear ribonucleoprotein-associated protein N
- E3 ubiquitin-protein ligase makorin-3
- Necdin
Sequence:
MGNLLSKFRPGCRRRPLPGPGRGAPAPLSRDASPPGRAHSVPTPRPFRGLFRRNARRRPSAASIFVAPKRPCPLPRAAAAPLGVLPAVGWGLAIRKTPMLPARNPPRFGHPSSVRIPPPSRMFTLLLPSPREPAVKARKPIPATLLEETEVWAQEGPRRVKKDEDPVQIEGEDDEKRTPLSSGEASSTSRSQGTQGDVASFRCSPGPLEGNVYHKFSENSMSEKAQASPASSCLEGPAMPSTHSQAGCARHLGKPDPDATAPPEPAVGCSLLQQKLAAEVLNEEPPPSSLGLPIPLMSGKRMPDEKPFCIPPRSAAPPRAARNRPCKRKMSIPLLLPLPPSLPLLWDRGELPPPAKLPCLSVEGDLHTLEKSPEYKRNSRILEDKTETMTNSSITQPAPSFSQPVQTTDSLPLTTYTSQVSAPLPIPDLADLATGPLILPIPPLSTTPKMDEKIAFTIPNSPLALPADLVPILGDQSNEKGGSYNSVVGAAPLTSDPPTPPSSTPSFKPPVTRESPISMCVDSPPPLSFLTLLPVPSTGTSVITSKPMNSTSVISTVTTNASAHLTSQTAVDPEVVNMDTTAPSQVVIFTSSLSSRVSSLPNSQIHCSAEQRHPGKTSVYTSPLPFIFHNTTPSFNQLFGKEATPQPKFEAPDGQPQKASLPSACVFLSLPIIPPPDTSTLVNSASTASSSKPPIETNAMHTTPPSKAVILQSASVSKKYLPFYLGLPGSGNTQPSGNTASVQGSTSLPAQSVRAPATASNHPLNPGATPQPKFGAPDGPQQKTSLPSAHDFLSLPIMVPPDTSTLVSSASAASLSKPAIDTSDMNTTPPSKTVILQSTFVSRKEEYIRFYMGLPGSGNTLHSDSIASAQVSTSFPAQADRRPTTTSSHPLNTGSISHSTLGATDGQQKSDSSFILGNPATPAPVIGLTSPSVQPLSGSIIPPGFAELTSPYTALGTPVNAEPVEGHNASAFPNGTAKTSGFRIATGMPGTGDSTLLVGNTIPGPQVIMGPGTPMDGGSIGFSMSAPGPSSTSGELNIGQGQSGTPSTTSVFPFGQAAWDPTGHSMAAAPQGASNIPVFGYTSAAAYIPGLDPPTQNSCSGMGGDGTRSIVGGPCVPAFQQCILQHTWTERKFYTSSTHYYGQETYVRRHVCFQLP
Protein: Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Q8C4V1)
Organism: Mus musculus (Mouse)
Function: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cell projection {ECO:0000250}. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions (By similarity). {ECO:0000250}.
Interaction partners:
- Filamin-A
Sequence:
MEERCESTESPQGQGRKNTKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLHGNKVIEHPCNEENPGKFLFDVVPGGERDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVVPYAKYEDFLSCATLLSKEEEAGVKELMKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSAQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDRLFPKDTEPQSKPQDGPNSNNNDGHKKATMGQLQNKENNNTKESPVRRCSWDKPESPQRSSVDNGSPTALSGSKTNSPRNSIHKLDISRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGVEKPQTTPNGSLQARRTSSLKSSGTKMGTHSVQNGTVRMGILNTDTLGNSLNGRSMSWLPNGYVTLRDNKQKEPAGESGQHNRLSTYDNVHQQFSSMSLDDKHSVDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFYVGNFEDPVLDGPPQDDLSHPGDYENKSDRRSVGGRSSRATSSSDNSETFVGNTSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMLSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGDLTVEPRRSERGNTIWIQ
Protein: Polyamine oxidase 1 (EC 1.5.3.14) (EC 1.5.3.15) (O64411)
Organism: Zea mays (Maize)
Function: Flavoenzyme involved in polyamine back-conversion. Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine, spermidine and their acetyl derivatives. Plays an important role in the regulation of polyamine intracellular concentration (Probable).
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:12586904}. Secreted, cell wall {ECO:0000269|PubMed:12586904}.
Interaction partners:
- Polyamine oxidase1
Sequence:
MSSSPSFGLLAVAALLLALSLAQHGSLAATVGPRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYHVQGKYD
Protein: Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Protein G9a) (Q9Z148)
Organism: Mus musculus (Mouse)
Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96KQ7}. Chromosome {ECO:0000250|UniProtKB:Q96KQ7}. Note=Almost excluded form nucleoli. Associates with euchromatic regions (By similarity). Does not associate with heterochromatin (By similarity). {ECO:0000250|UniProtKB:Q96KQ7}.
Interaction partners:
- Histone-lysine N-methyltransferase EHMT1
- Histone deacetylase 1
- DNA
- Chromobox protein homolog 3
- E3 ubiquitin-protein ligase UHRF1
- DNA
- Zinc finger protein SNAI1
- Lysine-specific histone demethylase 1A
- Lysine-specific demethylase 5C
- Protein Wiz
Sequence:
MRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRPRSLLSLPRAQASWAPQLPAGLTGPPVPCLPSQGEAPAEMGALLLEKEPRGAAERVHSSLGDTPQSEETLPKANPDSLEPAGPSSPASVTVTVGDEGADTPVGAASLIGDEPESLEGDGGRIVLGHATKSFPSSPSKGGACPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAATAGPEPSPATTAAQEGQPKVHRARKTMSKPSNGQPPIPEKRPPEVQHFRMSDDMHLGKVTSDVAKRRKLNSGSLSEDLGSAGGSGDIILEKGEPRPLEEWETVVGDDFSLYYDAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELLGCNAAILKRETMRPSSRVALMVLCEAHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGGTPPIGTAAPALPPLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPPGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPDLSSLPPINT
Protein: Sidestep IV, isoform C (Sidestep IV, isoform D) (Q9VFU7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MHHEETYQVVCRLIEREELEDREPCCRKKPTAPHPFPSPNVWRQLLLPLLMLSGISQVCSTYVEQDELMQNLDRPVPLTTVQGVLGRQAMLPCDISPQERDDAVYMVLWFREGDGEPIYNFDVRGRQFGQARLWSSPTAFGTRAHFSSTTHPAQLKIDNIRIEDEGVYRCRVDFRNSPTRNLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSEGNDIVLSCEVSGGRPRPNVTWYLDNTAIDESFEQRPDGKTINHLSYPNVGRQHLNSRLMCVASNTNLTPPNNRVVILDVNLKPIAVHILTKDRFVSADRTYDVECKSSGSKPPALITWWKGSKQLKKLTKNFNEPDNQSLSILTFTPGREDDGKYLTCRAENQFIDGSAIEDKWRLIVHYQPTTTLKIGSSLNPDDIKEGDDAYFECIVLANPKPYKMSWFHNGKELQHNISAGVILSDQSLVLQSVSRASAGDYTCLAVNSEGKGPSNPVTLRIRYAPICATDHEELLGALKHETLPLKCEVDSSPPADSFQWTFNSSGEQTELPARLHSSETGMSRLNYTPSTDLDYGTISCWAKNSIGTQKSPCVFQIVAAGRPFPLQNCSVTNQSVDSLQVDCLEGFDGGLPQGFMLELVELNTLRLARNITVSHTPVTFVIDNLDQAATYRMVIFAVNAKGRSEPTIIDDINFKGVAKFTGASTGLSMPLSPFLAGLTLFCGLLFAIFCIMLAAIYRRISNRRSDSNLKVAKHTQLTIPADCQLDPLHPGVQTDGSGNHQPHHSLLPLNCDGRNAVDCGALGDVGGGGVGVGLDGGIKGSSPIGLVAMPGDTLRSNARNRHSPMADQADIDDTDPDVIPNQYEKRPLKSLVSPPGFASPSNRLMQRDYLRETELTKGGSDVGMGAAEGLSSIGLMSSSGNEVLHYTFRPSKQISYATLNKKGITTCSPPLGSLNYSVSTSTPTSSYHLTPQPMEVSLLSPNNPSVTSSLSEYRFRTGPEIVTTSNRIQESCI
Protein: Protein disks lost (Codanin 1 homolog) (Protein vanaso) (Q8T626)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulator of cell proliferation and cell survival of differentiated cells independent of cell division. Essential for imaginal disks formation. Not involved in cell polarity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14667407}.
Interaction partners:
- Protein crumbs
- Protein PALS1
- Patj homolog
- Neurexin-4
- Histone chaperone asf1
- Artemis, isoform B
- Apollo, isoform A
Sequence:
MTAELKASDTEMTKPEERHLLQLLAQLEKVPHHQLEQKFVAYFKKVGKGDNQSNCTLEDFATYFLGALRQSTKRYYYSQNSETPVFPLTPIHQLKPPVADVVKEEEQQQLNESSILSRSSCSMSSTSNTTPAPQQPQGRRSTPGSGAQFCSTPNRSGGGGAGGGHSICLGNFLVNTPIQSHQRSKKKITPQKQQQNQHASLGSGTGAGATPQSKPRRRVLPMTISKNVSASSSFGDTSSFSNENNFWRISQSSEIFDRSQEAALEMEARKFLLLKKQEIKSEAPVNVSQQERTPEDEVFPEEAISLEGVANANHLQLLSTIYSLLMDLNLVPNVLRELSFVVHLLNVRDFGQSPVKSYVPSALEGLTQHKSCVYFAAKLLENQKKLLLQLDKRTLSVLLQNERLSLLPQGVVQELETHCQRRQDSTTPFAMDTSSSSQQNVYYHVENDSRDNFPSQNEFGAFKSQRDLFYKALKRWEVSHLNRGFNFPSELGPRIMDIYKKSEHPVNMTHLAKLFVNQLLISATETTESPEELGLKLDPLRHNKLAQRLVTSSSSVEGQFPRSQAFFRDFIAVCSSVAFLVHLKLELFVQLMRNNDSTFDLLQLTDDVAVEEQSAQQGPYIVRVQTMANMLILAKFLGYVTVMPFSGTTQHGNPTPPYLCPQQLQLRNHFRPDFNLREILERSMRQGKLLITLPWLVQYLAMLDLVSLHLPDAVATLELLYGLYADIRMAKLQPAAVFIARSCIGWLLDAQPQLVNGYYNYRAQEAGVGSISAIVDICLKDLSCHDKSHAPLLDELLPVACPFLQEFRVSITPSRQAKSGRFRYITTRLEQLQQNSSSISKDAIVASELSPAEQQQRKLVDAYLQSQNASTRRLIEFVTERTFKCVVKDAQQEILLPSKASADAKVNEIKSTMLEEVFQELHEIFQDARENACQRWKEHVHQMLDRRIEHSLDGLLPSSTNAVLRSTYAHLIRVQAQTQLQQWLQSSVLQSTFYHGDLQELATKVCNCNRNKADAAAAGGGGSSELQLSPDIGFSLSEFLYQLQQWLHCLSLRPEYVGSQEDLAELLRKAQKAVLLPKMPTVFYHLIGSGLVHLLQLLITRKPNFLDKDIISASCSVWRSQQLMDSKASPGIFDGLISISFVQEMANSADSFRMLETILRSMLQSGAIRADHLNELFMPLFAENWSPKVWCMLSELLQQLSLSGKDSEAHYASGDSPEDEAKSHLFMEMLADLSRDLDNF