wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein 227 (Q86WZ6)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein 45
Sequence:
MPSQNYDLPQKKQEKMTKFQEAVTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVGHLPFQPDMVSQLEAEEKLWMMETETQRSSKHQNKMETLQKFALKYLSNQELSCWQIWKQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKKSPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCHESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFGWSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPYKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECGKGFSQSARLEAHQRVHTGEKPYKCDICDKDFRHRSRLTYHQKVHTGKKL
Protein: Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) (B4DIH9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, phagosome membrane {ECO:0000256|ARBA:ARBA00037875}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037875}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000256|ARBA:ARBA00037803}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037803}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004163}. Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00037801}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037801}. Late endosome membrane {ECO:0000256|ARBA:ARBA00037845}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037845}. Lysosome membrane {ECO:0000256|ARBA:ARBA00037863}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037863}. Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
Interaction partners:
Sequence:
MLGVEETSWSYLFHYICQDRIVYLCITDDDFERSRAFNFLNEIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIMVRNIDLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLARAMCMKNLKLTIIIIIVSIVFIYIIVSPLCGGFTWPSCVKK
Protein: Quinolinate phosphoribosyltransferase [decarboxylating] 2b, mitochondrial (NtQPT2b) (QPRtase 2b) (EC 2.4.2.19) (A0A1S4CL59)
Organism: Nicotiana tabacum (Common tobacco)
Function: Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (Probable). Involved in the catabolism of quinolinic acid (QA) (Probable).
Subcellular location: Mitochondrion {ECO:0000255}.
Interaction partners:
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
- Quinolinate synthase, chloroplastic
- Quinolinate synthase, chloroplastic
- NAD
- NAD
- Uncharacterized protein C24B11.05-like
- Uncharacterized protein C24B11.05
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3-like
- nicotinate phosphoribosyltransferase
Sequence:
MFRAIPFTATVHPYAITAPRLVVKMSAIATKNTRVESLEVKPPAHPTYDLKEVMKLALSEDAGNLGDVTCKATIPLDMESDAHFLAKEDGIIAGIALAEMIFAEVDPSLKVEWYVNDGDKVHKGLKFGKVQGNAYNIVIAERVVLNFMQRMSGIATLTKEMADAAHPAYILETRKTAPGLRLVDKWAVLIGGGKNHRMGLFDMVMIKDNHISAAGGVGKALKSVDQYLEQNKLQIGVEVETRTIEEVREVLDYASQTKTSLTRIMLDNMVVPLSNGDIDVSMLKEAVELINGRFDTEASGNVTLETVHKIGQTGVTYISSGALTHSVKALDISLKIDTELALEVGRRTKRA
Protein: Transcriptional regulatory protein EmbR (P9WGJ9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Positively regulates the transcription of the embCAB operon. Exhibits ATPase and GTPase activities.
Interaction partners:
- Uncharacterized protein Rv0894
- Serine/threonine-protein kinase PknH
- Probable transcriptional regulatory protein
- Possible transcriptional regulatory protein
- site-specific DNA-methyltransferase
- Transcriptional repressor Mce3R
- Transcriptional regulatory protein KdpE
- Putative mycofactocin biosynthesis transcriptional regulator MftR
- Probable transcriptional regulatory protein
- HTH-type transcriptional regulator Rv1931c
Sequence:
MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVINRNRPVGVDALITALWEEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLSIPDNTCDLGRFVAEKTAGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVEPFATALVEDKVLAHTAKAEAEIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLSDRQSDALGAYRRVKTTLADDLGIDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTVLDQRTMASGQQAVAYLHDIASGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSAVTLNDGDHIRICDHEFTFQISAGTHGGT
Protein: Paramyosin (Uncoordinated protein 15) (P10567)
Organism: Caenorhabditis elegans
Function: Structural component of the muscle thick filaments which is involved in assembly and organization of sarcomere myofilaments. Involved in ovulation. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.
Subcellular location: Cytoplasm, myofibril, sarcomere, A band {ECO:0000269|PubMed:17326220, ECO:0000269|PubMed:27009202}. Note=Localizes in punctate patterns along the myosin heavy chain myo-3 filaments in myoepithelial sheath cells. {ECO:0000269|PubMed:17326220}.
Interaction partners:
- Myosin, essential light chain
- Troponin T
- CRE-UNC-96 protein
- Tropomyosin isoforms a/b/d/f
- Myosin regulatory light chain 1
- Troponin I 2
- Myosin regulatory light chain 2
- Myosin-3
- Muscle M-line assembly protein unc-89
- Actin
Sequence:
MSLYRSPSAALLKSPSQAAFGAPFGSMSVADLGSLTRLEDKIRLLQEDLESERELRNRVERERADLSVQVIALTDRLEDAEGTTDSQIESNRKREGELSKLRKLLEESQLESEDAMNVLRKKHQDSCLDYQDQIEQLQKKNAKIDRERQRVQHEVIELTATIDQLQKDKHTAEKAAERFEAQANELANKVEDLNKHVNDLAQQRQRLQAENNDLLKEVHDQKVQLDNLQHVKYTLAQQLEEARRRLEDAERERSQLQSQLHQVQLELDSVRTALDEESIARSDAEHKLNLANTEITQWKSKFDAEVALHHEEVEDLRKKMLQKQAEYEEQIEIMLQKISQLEKAKSRLQSEVEVLIVDLEKAQNTIALLERAREQLERQVGELKVRIDEITVELEAAQRELRAVNAELQKMKHLYEKAVEQKEALARENKKLHDELHEAKEALADANRKLHELDLENARLAGEIRELQTALKEADAQRRDAENRAQRALAELQALRIEMERRLQEKEEEMEALRKNLQFEIDRLIAALADAEARMKSEISRLKKKYQAEIAELEMTVDNLNRANIEAQKTIKKQSEQLKILQASLEDTQRQLQQVLDQYALAQRKVAALSAELEECKTALDNAIRARKQAEVDLEEANGRISDLISINNNLTSIKNKLETELSTAQADLDEVTKELHAADERANRALADAARAVEQLHEEQEHSMKIDALRKSLEEQVKQLQVQIQEAEAAALLGGKRVIAKLETRIRDLETALDEETRRHKETQNALRKKDRRIKEVQQLVDEEHKNFVMAQDTADRLTEKLNIQKRQLAESESVTMQNLQRVRRYQHELEDAEGRADQAESSLHLIRAKHRSSVVTGKSSSKIFVTEDDY
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (Q7KPL1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
Sequence:
MVQMPPPPSNAPTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHAMPIDGPRAAA
Protein: PWWP domain-containing protein 2A (F7AQ22)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: H2A.Z-specific chromatin binding protein which plays an important role in the neural crest cell differentiation and/or migration during early development and is essential for the development of the head and eye. Acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96N64}.
Interaction partners:
- ATR serine/threonine kinase
- Nibrin
- Double-strand break repair protein
- Tumor protein p53 binding protein 1.
- Toll-like receptor13.
- Cell death-inducing p53-target protein 1.
- Telomere length regulation protein TEL2 homolog
- Ku domain-containing protein.
- FA complementation group M.
- BCL2/adenovirus E1B 19kDa interacting protein 3-like.
Sequence:
MAAVAGAPGPGEGGESEQDSETIPGERRLGRLSCEPMEAELDSERRSLVRCEPCCGMEIDTQENAGPDIEQLGDSGAEQVYGIHTNSEFVSVSAVDYMGINQGQIAPENRKARSEQLPREPFLQRQPIPMILSEVTDSGIYTGLCLEEAKFSSNNGSEASLNYSECDNRSVGTTEGSVVTSGIDSLIPGSEVQVTLDHIIQDALVVSFCHGNRIFSGVLMDLSKRFGPHGIPVTVHPRREYKNKPVESIQEESKSFHEEPLVKSEENSPEDVTPIQQLENCKVQNLWTTKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKKKIYREEPTSIMNAIKLRPRQVLCDKCKNNVVADKKEIRKVATDSYKTEEGKRRRHETVTTVNKKLKTDHKVNGKSQNESQKRTPITKVTNLAHGRGKVVKVPSQTSAAKTQMHTKEVLQNKNMDHVKAREVLKMAKEKAQKKQKVTTSSKNAHSKVHFTRRLQNSSSGTLPPRLRIKPQRYRNEENDSSLKPGLETLRSSKIGIKPQTRYSATRSAGETPSEIQSPSNGPEEISSEMQDTNVCVPPEEQDLQQTLGKRGSKSNITVYMTINQKKANSSSASVCSSDSTDDMKSSHSECSSTENFDFPPGSMHAPSSSSSSSASSKEEKKLSNSLKIKMFSKNVSKCVTPDGRTICVGDIVWAKIYGFPWWPARILAITVSRKDTGLLVRQEARISWFGSPTTSFLALSQLTPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFET
Protein: Secreted frizzled-related protein 2 S homeolog precursor (Sfrp2-prov protein) (Q7ZXM6)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
Sequence:
MWHSGSRYVVVVLVVLLACDCMDSVRALFPFGQPEFSYKRSNCKPIPATLVLCHDIEYPNMRLPNLLGHESMKEVLQQASSWIPLVQKQCHQDTKKFLCSLFAPVCIDDLDETIKPCRSLCEQVKDSCAPVMSAFGFPWPDMLECSRFPQDNDLCIPPATNEHQVPVTREAPKVCDACKNSNEDDNDIVENLCKNDFALKIKVKEIAYINGDTKIIPETKGKTIYKLNGVTERDLKKTVLWLKDGLQCTCDEMNDINAPYLVMGQKLGGELVITSVKRWQKGQQKFKRITRSIRKLQC
Protein: Defective in germ line development protein 3 (Germline development defective 3) (Q95ZK7)
Organism: Caenorhabditis elegans
Function: Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continued production of sperm and inhibition of oogenesis. Together with gld-2, promotes the transition from mitosis to meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12431376, ECO:0000269|PubMed:19461891}. Cytoplasmic granule {ECO:0000269|PubMed:12431376, ECO:0000269|PubMed:19461891}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12431376, ECO:0000269|PubMed:19461891}. Note=Localizes to P granules. Found also in particles near but not coincident with P granules. {ECO:0000269|PubMed:12431376, ECO:0000269|PubMed:19461891}.
Interaction partners:
- Poly
- Fem-3 mRNA-binding factor 2
- Fem-3 mRNA-binding factor 1
- Poly
- RRM domain-containing protein
- Poly
- Poly
- Female germline-specific tumor suppressor gld-1
- Poly
- Nanos-type domain-containing protein
Sequence:
MGEQSHEKDHDEAHSYNPFVRSAVEYDADTRLQMAENAASARKLFVSSALKDIIVNPENFYHDFQQSAQMAEDANQRRQVSYNTKREAHIHQLKAQGLPLPSNIPMIEINPTRVTLNMEFESQYYSLMTSDNGDHENVASIMAETNTLIQLPDRSVGGTTPDPFAQQVTITGYFGDVDRARMLMRRNCHFTVFMALSKMKMPLHELQAHVRQNPIQNVEMSFVDAPEKNGIVTTYLRITAREKNQHELIEAAKRLNEILFRESPAPENNFTLHFTLSTYYVDQVLGSSSTAQLMPVIERETTTIISYPCYNNRNETRGNIYEIKVVGNIDNVLKARRYIMDLLPISMCFNIKNTDMAEPSRVSDRNIHMIIDESGIILKMTPSVYEPADLLSGEVPLNCASLRSKEFNIKKLYTAYQKVLSKKFDFIAPQPNDYDNSIWHHSLPANFLKNFNMPCRGELSDGSNGRRHRSSSIASSRSKHSYMSKGKQFSESSGGPSRSHTRVSSFSENSSTVPIMQFPTPHFAPPMLTPHHHMLKYVYLQQHQQAQTFLKGAAGLHPGTHIMFPPPIIVDGSFVSALPFADPVVFDGFPYVHGLFPVNEAEQHRNHRESSPSLRSTQEIRKPSRNMGNRPSSSTGSYYPSTTPRQRVYEQVREDDLRSHIGSRRTSVNGDDQNVESMHDQGYERQYPRQHQRLQKDDQQRWKTGSRGDIHSSRTINVHRDVRNSNEYDFHVGNSGPAKRSPSLEQVQLQMTHHLKLKSNDVDLDHEKLYMHESPHNDSDTTVSASGFGNDLMDGDFVQRFLSNANINESGRRPRTVSCFTEKDGQSARYIDSDGAYSVVDHASTHQSRSYDSFRKVGDNGVTKTILEPRARVEKDYGKISLEHKTKYSNEYGDEEKSAENDTSSLGSRQYRIDPMKLIASVRESSEQLPRIHERQFSDVLNEKEKEIADKSIESTVTQDLSLDETSTY
Protein: threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) (B2RDX5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEMYNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIAKVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGISFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRAVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFTLVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEF
Protein: Caseinolytic mitochondrial matrix peptidase chaperone subunit Xa (Zgc:92303) (Q66HW5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSCTCAIAARKFINSAHKGISGSRVQLLSLSRPGTREVRLARRVPVRSFSETAVYYASKDGVKDGDGGKKSVGEGSGKRTSSGNSGKGGSQLRCPKCGDPCTHVETFVSSTRFVKCEKCHHFFVVLSETDTKKSLSKDPESAAEAVKLAFQQKPPPPPKKIFAYLDKYVVGQDHAKKVLSVAVYNHYKRIYNNMPAGSRQQQVEVEKQASLTPRELLQIAGISPHGNALGASMQQQLNQQTPPEKRGGEVLDSTHTDIKLEKSNIVLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYVIEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNTRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNMGKGRRAAAAADLANTTGGEVDAVAEIEEKDRLLKHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEETLVRILTEPRNAVVPQYQALFSMDKCELNMTPDALRAIARLALERKTGARGLRSIMEKLLLDPMFEVPHSDIVSVDVSKDVVQGKAPPQYIRAAAKESSEEEYDSGIEEENWTRQADAAKN
Protein: C4-dicarboxylate TRAP transporter large permease protein DctM (Q9HU16)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in C4-dicarboxylates uptake.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:O07838}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- C4-dicarboxylate TRAP transporter small permease protein DctQ
- C4-dicarboxylate-binding periplasmic protein DctP
- Probable C4-dicarboxylate-binding periplasmic protein
- Probable c4-dicarboxylate-binding protein
- TRAP transporter large permease protein
- TRAP transporter small permease protein
- TRAP transporter substrate-binding protein DctP
Sequence:
MTILFLFLLLFLLMFIGVPIAVSLGLSGALTILLFSPDSVRSLAIKLFETSEHYTLLAIPFFLLSGAFMTTGGVARRLIDFANACVGHIRGGLAIAAVLACMLFAALSGSSPATVAAVGSIAIAGMVRSGYPQAFGAGIVCNAGTLGILIPPSIVMVVYAAATETSVGKLFIAGVVPGLLLGLILMVVIYIVARVKKLPAMPRVSLREWLASARKALWGLLLMVIILGGIYSGAFTPTEAAAVAAVYSAFVALFVYRDMRLSECPKVLLESGKLTIMLMFIIANAMLFAHVLTTEQIPQSIASWVTELGLSPWMFLLVVNIVLLIAGNFMEPSAIILILAPIFFPIAMELGIDPIHLGIIMVVNMEIGLITPPVGLNLFVTSAVTGMPLGATIRAALPWLMILLVFLIIVTYIPAVSLALPNWLGMS
Protein: ER degradation-enhancing alpha-mannosidase-like protein 1 (O94726)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Alpha-mannosidase-like protein involved in endoplasmic reticulum-associated degradation (ERAD). Delivers misfolded glycoproteins to proteasomes. It lacks mannosidase activity.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250}.
Interaction partners:
- Protein OS-9 homolog
- ERAD-associated E3 ubiquitin-protein ligase hrd1
- Ubiquitin-conjugating enzyme E2-18 kDa
- Putative protein disulfide-isomerase C1F5.02
Sequence:
MGSLHSIFCVCLILLCIFKENSIVGAINSARMVELRETSRRLFYHGYNNYMQFAFPNDELAPLSCEGLGPDYENPNNIGVNDVRGDYLLTLVDVLDTLVVLGDREGFQDAVDKVIHHINFERDTKVQVFEATIRILGGLLSSHIFASEEKYGFQIPLYKGELLTLATELAERLLPAFRTPTGIPFARINLMKGVAYREVTENCAAAASSLVLEFSMLTALTGNNKFKASAENAFFSVWKRRSGIGLLGNSIDVLSGRWIYPVSGVGAGIDSFYEYAFKSYIFLGDPRYLEVWQKSLESLRHYTASLNEYYYQNVYSANGMVMSRWVDSLSAYFPGLLVLAGELELAKKMHLYYFSIYLKFGQLPERYNLYTKSIELNGYPLRPEFAESTYYLYRATKDVFYLHVGELLLSNIENHLWTPCGFAAVENLEKYTLSNRMESFFLSETLKYLFLLFDDDNPIHRSHHDFIFTTEGHLFPVTNQTRLSTSQRIYDGGEVCVAEDYDRSKWPMLYSLIASRDDYDYVSHLVGIDNKAIPSYLIDPSGVCKRPEYSDGFELLYGSALVSPIKSVERVTNNVYISDIIGNKLKFVQKEGSNSLFLYTAGAESINENDTVFLTDPDYETFTRPDALYFDRTIAQLENPNSGQKTFGKFLQFDNDNSLPSKVFKTVLLNNSMCQKPSDTLDKDTAYIAPLGNCSWVQQAKNTNKAGLLILITDGEFINPLENIHSQNSLFNWVKPYIPPTILLKNENNFVSKWANVSVRQSDFDAPSYFQGTPVSNLYLCLKCINS
Protein: Coiled-coil domain-containing protein 182 (Q9D9C6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MEALFQAGSILMKVNTLQGKKMVESGLQSGDLSLSQSWPSYLPLPADLEILQQKVAGVQRELEDFKEEALKAIRYLEDAFCQMSGVLAQQEEQAARVKQRLREEEDRGIVRNKVLTFLLPREKQLREHCQRLENMLVRSHNPLRAIRKSQAD
Protein: Orf03 protein (Tetratricopeptide repeat (TPR)-like superfamily protein) (Q38955)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Chloroplast sensor kinase, chloroplastic
- RNA polymerase sigma factor sigA
- Casein kinase II subunit alpha-4, chloroplastic
- Rhodanese-like domain-containing protein 4, chloroplastic
- Protein TIC 62, chloroplastic
Sequence:
MAAVIGNVALLLDVNSHRTVVTDRRIRLTVVDVVLNLQKRDSHSHVSHYAALSSNKPLESDGEARVRRFLTRGKANSRANAVDFDDAGSSDEESSDGGGGGGDEEEEEEYFDVEKERKRRAKEFHDTKELERKAEELQYKIDEEGDDSEEKKRMRVKRELQKVAQEQAERRKTAELMFELGQKAYGKGMYGRAIEFLEGALTIIPRPTLFGGEIQIWLAMAYEANNRHADCIDLYQQLEKKHPSPGIRRQASELRYILQAPKLKISQEEMVTIPMIGSSYDSYAVTWSDKERDKERRMNASTTNQLNSSDDFLGKLLVWRPVVGMEKNRVFWLALTLWFGLVGAALILQR
Protein: Protein phosphatase, Mg2+/Mn2+ dependent, 1K (F6PA41)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSVALLVRYATLSGSRVCSRAAFNLTNAHQEDPRRALHTPSSPRFSNSRFDPDSSGRPTTWDSFGIWDNRIDEPILLPSSIRYGKLIPKVNLSRVGSASQIGQRKENEDRYQMSQMTDNIMYFAVFDGHGGAEAADFCHKNMEKHIKDIAAEETNLEFVLTKAFLEVDKALARHLHFSADAADPAYPL
Protein: Chromatin structure-remodeling complex protein RSC8 (Remodel the structure of chromatin complex subunit 8) (SWI3 homolog) (P43609)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and for repression of CHA1 expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:12697820}. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Interaction partners:
- Chromatin structure-remodeling complex protein RSC6
- Chromatin structure-remodeling complex subunit RSC4
- Chromatin structure-remodeling complex subunit RSC2
- Chromatin structure-remodeling complex protein RSC30
- Chromatin structure-remodeling complex subunit RSC9
- Actin-related protein 7
- Chromatin structure-remodeling complex subunit RSC1
- Actin-like protein ARP9
- Chromatin structure-remodeling complex protein RSC3
- Chromatin structure-remodeling complex subunit RSC7
Sequence:
MSDTEKDKDVPMVDSHEATEEPPTTSTNTPSFPHLAQEQAKEESATLGAEVAHKKINYEQEAQKLEEKALRFLAKQTHPVIIPSFASWFDISKIHEIEKRSNPDFFNDSSRFKTPKAYKDTRNFIINTYRLSPYEYLTITAVRRNVAMDVASIVKIHAFLEKWGLINYQIDPRTKPSLIGPSFTGHFQVVLDTPQGLKPFLPENVIKQEVEGGDGAEPQVKKEFPVNLTIKKNVYDSAQDFNALQDESRNSRQIHKVYICHTCGNESINVRYHNLRARDTNLCSRCFQEGHFGANFQSSDFIRLENNGNSVKKNWSDQEMLLLLEGIEMYEDQWEKIADHVGGHKRVEDCIEKFLSLPIEDNYIREVVGSTLNGKGGDSRDGSVSGSKLMECVNDAVQTLLQGDDKLGKVSDKSREISEKYIEESQAIIQELVKLTMEKLESKFTKLCDLETQLEMEKLKYVKESEKMLNDRLSLSKQILDLNKSLEELNVSKKLVLISEQVDSGIQLVEKDQEGDDEDGNTATGHGVKRVGKEGEEVGEGDSIAKLQPQVYKPWSL
Protein: EH-domain containing 4 (Q8R3Z7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004159}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004159}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004159}.
Interaction partners:
- Rabenosyn, RAB effector
Sequence:
MFSWMGRQAGGRERSGGMDAVQTVTGGLRSLYQRKVLPLEEAYRFHEFHSPALEDADFENKPMILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISIIDSPGILSGEKQRISRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKEMPSMFGKENKKRELIFRLPEIYVQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLKPKLIEAVDNMLTNKISSLMSLISQEEMNMPTQMVQGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEEEFALAKHLIKIKLDGYELPNSLPPHLVPPSHRKSLPKAD
Protein: histidine kinase (EC 2.7.13.3) (Q5E615)
Organism: Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Interaction partners:
- acyl-homoserine-lactone synthase
- Aerobic respiration control sensor protein
- histidine kinase
- histidine kinase
- histidine kinase
- Autoinducer phosphorelay protein LuxU
- histidine kinase
- Autoinducer 2-binding periplasmic protein LuxP
- histidine kinase
- diguanylate cyclase
Sequence:
MLTTLPKVYLLLTTSAIILLWVGYFIRSLYRERTKVNPYIYSSYIFYAFFIILWILSNAYFQSPLLTYFDESVAIFMALFANMTSYLAFAFAFLFSCRLASKHSDKRLSKWQFGLTSITTLVALIVNVIPNLTVIGVTIQAPSVFTIEFGPFAPLFFLNAFLFVILTSINFFKLRKSNIKLNKEKSVYLMIGIFIYMISTIASQIIIPVIWADFSYTWLPPTLSVTEALLIGYTLLYHRLYSFKYLLFWSLSYSINLILYITPIVIIYSSSSNPNLFYVYALSIIITGLFWDKTLKKSKKIASIIIYKDQQTPVEKIYKIAEEFKYSSSNAIIKLASILNTPKEELLLIGKNTNYNIFIPHLNESHSALVKDELDYQIHYALETGNSALHQVQEKMDQSKTALILPIFGENKLISHFLISANKHDNATFSNEEISAIQWVLTKVQGYIESEQKVRQSQALANSIAHEMRNPLSQLQYHFEKIKHHYQKNTEHEKQEDLIKNELNQGCLAIQKGAQLIDIILSEAKNTTISDALFQHYSISLLTQQIIDEYVFDSEEMKQKITLNLEDDFIVNINDTLYGFILFNLLRNATHYFDEYKSSISIRLVRGFATNKLIFRDTGPGIDSHILPNIFDDFFTHNKKGGSGLGLSYCLRVMHAFEGNIVCYSTKGEFTEFVLSFPRIEGNINALNTKPSSPPLIKDKDNSLKTVLIVDDKKVQRMLIHTFINKDNLTLLQAENGEEAVEMATNNKIDLIFMDSRMPIMNGIDAAKKIKILYPHLPIIALTGESSHEEISAITQVMDGYLTKPVSKTQLLQVVDKWL