wanglab/gogpt-training-data huggingface dataset:
Protein: Probable doxorubicin resistance ABC transporter permease protein DrrC (P9WG21)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Doxorubicin resistance ATP-binding protein DrrA
- Doxorubicin resistance ABC transporter permease protein DrrB
- Phenolphthiocerol/phthiocerol polyketide synthase subunit E
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Phthiocerol/phthiodiolone dimycocerosyl transferase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit D
- Phenolphthiocerol/phthiocerol polyketide synthase subunit A
- Long-chain-fatty-acid--AMP ligase FadD26
- Phenolphthiocerol/phthiocerol polyketide synthase subunit B
- Multidrug efflux system ATP-binding protein Rv1218c
Sequence:
MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLAYVVTHDSGLYSIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISRILANAIRTLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVILGIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTGLVPLNSYPGWIQPFVAHQPVSYAIAAMRGFAMGGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH
Protein: Kininogen-1a [Cleaved into: Maximakinin (Bombinakinin M); Bradykinin; Bombinakinin-GAP (Bombinakinin M gene-associated protein)] (Q7T3L1)
Organism: Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Function: Plays a role in the control of feeding by the brain; intracerebroventricular administration of the peptide induced significant decrease in food intake in rats. Inhibits the bradykinin-induced in vitro relaxation of rat arterial smooth muscle. May target bradykinin receptors (BDKRB).
Subcellular location: Secreted {ECO:0000269|PubMed:12668203}.
Interaction partners:
Sequence:
MRLWFCLSFFIVLCLEHFTGTLADERNVPESEEKTEQFLRDLPKINRKGPRPPGFSPFRGKFHSQSLRDLPKINRKGPRPPGFSPFRGKFHSQSLRDLPKINRKGPRPPGFSPFRGKFHSQSLRDLPKINRKGPRPPGFSPFRGKFHSQSLRDLPKINRKGPRPPGFSPFRGKFHSQSLRDLPKINRKGPRPPGFSPFRGKFHSQSLRDLPKINRKGPRPPGFSPFRGKFHSQSLRDLPKINRKGPRPPGFSPFRGKFHSQSLRDMYEIKQYKTAHGRPPICAPGEQCPIWVGK
Protein: CMP/dCMP-type deaminase domain-containing protein (Q54DP5)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Ponticulin-like protein C2
- Ponticulin-like protein C5
- Ponticulin-like protein C4
- Ponticulin-like protein C1
- Ponticulin-like protein C3
- PhoPQ-activated pathogenicity-related protein
- Probable phosphoglycerate mutase
- Secreted protein A
Sequence:
MKIALLLTILLAFIALSFACDEFNPNISTIGECTATQKVSWKPTDNAQVLTPADLDPQELGMHEERMAYVLAIAKQQNKKFVASIYHQNGTLMCLGVNTGKPNIISHGEIVAINNCTALHGITSFTNYTLYTSGEPCAMCSAALLWADFKTIVWGTFNSDLLCKICMSNIPMDSSYIFGRYYGLRASPPRVIGGVLRTEADAWFGSYCSKPTSIYYIKPQCVCTNTTSPLKIDQTRYSSWFENGKTVSQFGGIITNTGSVTVTNPTFTSSPLRPNSIWGLAVDETKNTWALQWYPVIQPGQTFSFGYIIDGEDQIAFQPTA
Protein: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FERN, mitochondrial (3-hydroxyl-ACP dehydratase FERN) (EC 4.2.1.59) (Protein FERN-LIKE) (SlFERN) (A0A3Q7HWE4)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: 3-hydroxyl-[acyl-carrier-protein] (3-hydroxyl-ACP) dehydratase required for mitochondrial fatty acid synthesis (mtFAS). Essential for photorespiration, tomato morphogenesis and plant development, probably by influencing mitochondrial membrane lipid composition and other lipid metabolic pathways, and by contributing to energy supply and reactive oxygen species (ROS) homeostasis.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:35640121}.
Interaction partners:
- acetyl-CoA C-acyltransferase
- acetyl-CoA C-acyltransferase
- acyl-CoA oxidase
- Uncharacterized protein
- Acetyl-CoA C-acetyltransferase
- Uncharacterized protein
- Acetyl-CoA C-acetyltranferase 1
- Acyl-coenzyme A oxidase
- acyl-CoA oxidase
- Acyl-CoA dehydrogenase
Sequence:
MLMKRLFSSSHVFSSSSASSNLLKIGSVLKQARTFADDDVLGYSKLTHDANPLHFDAECAKNAGFTDCLVPGMLVASLFPRIIAAHFPGAIYVSQTLHFKLPVYIGDEIIAEVQAVSIRQIKNKYIAKLSTKCIKRDGPLVIDGEATAMLPSLVMEPPNLEITSS
Protein: Collagen, type XV, alpha 1b precursor (mRNA for collagen XVb alpha 1 chain) (D3GN36)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MKFRLLSWLVGAHLALGYLSSALHVMEERGSKGHLILTDLVGMPLPPSVSFITGYEGYPAYSFGPHANVGRLTQSFVPEPFFTDFAIIVTVKPSSSRGGVLFAITDPSQTIVQLGLALTPVEDQTQRIVLYYSEPRSANSAEVASFKVPDMTQQWSRFTLSVERQEVRLYMDCDEYHIAPFKRSQQPLSFKPGSGIFVANAGSTGLERFVGSIQQLVIKPDPRAAEEQCEEDDPSLQASGDRSGDGDYDDEEEHARREETFGQTNNKEKTLRPTSPVEAPPIQSPDIEEGGFSGHVTPIDERLLRGTYKTDETGERVGQKGERGEPGPAGPPGPPGPPGTSVPIRRSGQPGPRGPQGPIGQPGGRGRPGKDGQPGSKGEDGKPGQRGQTGPPGLPGESGVKGEKGDPGVGRTGLPGPPGPPGPPGPSKPVKVPYGFDALGSGFGDADIDTELLRGPPGPPGPPGIPGPPGPNSPLGGLLPGPPGAPGKDGRDGQSGLPGVPGQDGLPGQQGPKGAKGEHGIRGPPGPKGENGAPGRGPPGPFGTMGPRGLPGPPGPPGPPGPINNNFMVDTLKDFEGSGESGSFLGTGILKGYQGPPGLPGPPGPQGPPGANGPPGLSVKGERGSPGPDGIHGLVGLPGARGPKGDKGNPGEKGERGRDGLNITGPPGPPGPPGPIINFQDLFLNDTAAKLNLTKIRGLPGPMGPEGLPGRAGFPGPRGPKGEIGFPGVQGPPGLKGDKGEPGVSIAADGSIITSLRGPRGPKGTKGDIGLAGPHGIPGPIGPPGLKGGYGIPGRPGRPGIAGRKGDKGDASGPSGPPGPPGPPGPPGRVIGLNGGPKGDNGYNGQKGEKGDPGLPGPPGLPGRTGLVGPKGESIVGPPGDTGAPGPPGLPGYGSPGPQGPPGAPGPPGTSSLYSSAASLPGPPGPPGPPGAPGYGNPVSTYKNSQTLMRESSQAAEGTMGYVIDKSELYIRELKSFLPGYNLLPDTTHSMPALHLVALNAPFSGDMHGIRGADYQCYQQARARGLTSTYRAFLSSHLQDLSTIVKKADRFNLPVVNLKGEVLFSSWMAMFSGNGGVFDPLTPIYSFDGRNVLTDQAWSQKLVWHGSSTVGIRMTTNYCEAWRTGDMAVTGQASLLQTGRLLGQHTRSCSNHFIILCIENSYIQHPGRN
Protein: Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Aldolase 3) (Brain-type aldolase) (Scrapie-responsive protein 2) (Zebrin II) (P05063)
Organism: Mus musculus (Mouse)
Interaction partners:
- Triosephosphate isomerase
- ATP-dependent 6-phosphofructokinase, liver type
- ATP-dependent 6-phosphofructokinase, platelet type
- ATP-dependent 6-phosphofructokinase, muscle type
- Glyceraldehyde-3-phosphate dehydrogenase
- Transaldolase
- Fructose-1,6-bisphosphatase 1
- Fructose-1,6-bisphosphatase isozyme 2
- Phosphoglycerate mutase 1
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Sequence:
MPHSYPALSAEQKKELSDIALRIVTPGKGILAADESVGSMAKRLSQIGVENTEENRRLYRQVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKGILVGIKVDKGVVPLAGTDGETTTQGLDGLLERCAQYKKDGADFAKWRCVLKISDRTPSALAILENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACPIKYSPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASLNLNAINRCPLPRPWALTFSYGRALQASALNAWRGQRDNAGAATEEFIKRAEMNGLAAQGRYEGSGDGGAAAQSLYIANHAY
Protein: Chorion peroxidase (EC 1.11.1.7) (Peroxinectin-related protein) (Dpxt) (Q9VEG6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for ovarian follicle maturation. Involved in the formation of a rigid and insoluble egg chorion by catalyzing chorion protein cross-linking through dityrosine formation and phenol oxidase-catalyzed chorion melanization.
Subcellular location: Secreted {ECO:0000269|PubMed:18216169}. Note=In the chorion layer of the mature eggs.
Interaction partners:
- Maternal effect protein oskar
- Female sterile
- Thioredoxin-1
- Protein matrimony
- Tubulin alpha-4 chain
- Vitellogenin receptor Yl
- Deubiquitinase otu
- CG5272 protein
- CG3509 protein
- Poly
Sequence:
MSRILFILLLLIVTQLSELQAAAFSVRQNRFDEVPDLQTPAPLATSTESSKKPEKATSGLLKKCLPCSDGIRCVPQIQCPAHVRMESHEKPQICDLPAGKFGYCCETGQNHTAPKPETSPKERRSGFPTILSPAVLDEARRNFEHLMHGVAQIPVRRGFPDFAHGLVFHSTAKDDLHNFAISNSAIEQVMTTQLFGKKEQVPVEDFITNNVPIKFTETPLAHHCQPPPVCGNIRSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSSDGTPLLGARKISRTLLSDVDRPHPKYNLMVMQFGQVLAHDISQTSSIRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAFGVRCLNFVRLSLVPSPDCQLSYGKQLTKVTHFVDASPVYGSSDEASRSLRAFRGGRLRMMNDFGRDLLPLTNDKKACPSEEAGKSCFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAEMQHITYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSVDGKFQIRQEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLYSQPMQQVDSSISQGLSRFLFRGDNPFGLDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQFPIEIAQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDNGINPGAFNPLQLQEIRKVTLARLLCDNSDRLTLQAVPLAAFVRADHPGNQMIGCDDPNLPSVNLEAWRA
Protein: Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100) (O75448)
Organism: Homo sapiens (Human)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 29
Sequence:
MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDIEDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRGSVLQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Protein: Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase) (Q99707)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:27771510}.
Interaction partners:
- Methionine synthase reductase
- Methylenetetrahydrofolate reductase
- C-1-tetrahydrofolate synthase, cytoplasmic
- Serine hydroxymethyltransferase, cytosolic
- Cystathionine beta-synthase-like protein
- Cystathionine gamma-lyase
- Adenosylhomocysteinase
- S-adenosylmethionine synthase isoform type-1
- Serine hydroxymethyltransferase, mitochondrial
- S-adenosylmethionine synthase isoform type-2
Sequence:
MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD
Protein: Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29) (Q63481)
Organism: Rattus norvegicus (Rat)
Function: The small GTPases Rab are key regulators in vesicle trafficking. Essential for maintaining the integrity of endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact central nervous system (CNS).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O14966}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O14966}. Golgi apparatus {ECO:0000269|PubMed:23395371}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O14966}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O14966}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23395371}. Note=Colocalizes with GM130 at the Golgi apparatus (By similarity). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (By similarity). Colocalizes with TGN46 at the trans-Golgi network (TGN) (By similarity). Colocalized with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:23395371). {ECO:0000250|UniProtKB:O14966, ECO:0000269|PubMed:23395371}.
Interaction partners:
- Cyclin-G-associated kinase
- Leucine-rich repeat serine/threonine-protein kinase 2
- BAG family molecular chaperone regulator 5
- RILP-like protein 2
- RILP-like protein 1
- Vacuolar protein sorting-associated protein 35
- Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
- Protein phosphatase 1H
- Geranylgeranyl transferase type-2 subunit alpha
Sequence:
MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDSEMVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPSGEPVPCLLLANKSDLSPWAVSRDQIDRFSKENGFTGWTETSVKENKNINEAMRVLVEKMMNNSREDIMSSSTQGNYINLQTKPSPGWTCC
Protein: Neurogenic differentiation factor 1 (NeuroD1) (Basic helix-loop-helix factor 1) (BHF-1) (Q64289)
Organism: Rattus norvegicus (Rat)
Function: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3' (By similarity). Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A (By similarity). Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine (By similarity). Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification (By similarity). Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12297313}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:12297313}. Note=Colocalizes with NR0B2 in the nucleus (By similarity). In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation. {ECO:0000250}.
Interaction partners:
- Paired box protein Pax-6
- Achaete-scute homolog 1
- Transcription factor E2-alpha
- Paired box protein Pax-4
- Homeobox protein Nkx-6.1
- Transcription factor 4
- Nestin
- Myelin transcription factor 1-like protein
- Neuroendocrine convertase 2
- NK2 homeobox 2
Sequence:
MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDELEAMNAEEDSLRNGGEEEDEDEDLEEEEEEEEEEDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNPDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSTEFEKNYAFTMHYPAATLAGPQSHGSIFSSGAAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD
Protein: MccB protein (Q47506)
Organism: Escherichia coli
Interaction partners:
Sequence:
MDYILGRYVKIARYGSGGLVGGGGKEQYVENLVLWENIIKTAYCFITPSSYTAALETANIPEKDFSNCFRFLKENFFIIPGEYNNSTENNRYSRNFLHYQSYGANPVLVQDKLKNAKVVILGCGGIGNHVSVILATSGIGEIILIDNDQIENTNLTRQVLFSEDDVGKNKTEVIKRELLKRNSEISVSEIALNINDYTDLHKVPEADIWVVSADHPFNLINWVNKYCVRANQPYINAGYVNDIAVFGPLYVPGKTGCYECQKVVADLYGSEKENIDHKIKLINSRFKPATFAPVNNVAAALCAADVIKFIGKYSEPLSLNKRIGIWSDEIKIHSQNMGRSPVCSVCGNRM
Protein: Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) (Protein kinase Myak) (O88904)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12529400, ECO:0000269|PubMed:18219322, ECO:0000269|PubMed:20579985}. Cytoplasm {ECO:0000269|PubMed:12529400, ECO:0000269|PubMed:18219322, ECO:0000269|PubMed:20579985}. Nucleus speckle {ECO:0000269|PubMed:12529400}. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation. {ECO:0000269|PubMed:18219322}.
Interaction partners:
- Cellular tumor antigen p53
- Ras association domain-containing protein 5
Sequence:
MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQASSSHQVANFNLPAYDQGLLLPAPAVEHIVVTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVESNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMSHLLDFPHSSHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSAWQQLPGVALHNSVQPAAVIPEAMGSSQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLEVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPNSSSLKARSNVISYVTVNDSPDSDSSLSSPHPTDTLSALRGNSGTLLEGPGRPAADGIGTRTIIVPPLKTQLGDCTVATQASGLLSSKTKPVASVSGQSSGCCITPTGYRAQRGGASAVQPLNLSQNQQSSSASTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL
Protein: Mu-theraphotoxin-Df1a (Mu-TRTX-Df1a) (P0DPC2)
Organism: Davus fasciatus (Costa Rican tiger rump) (Cyclosternum fasciatus)
Function: Inhibits sodium channel Nav1.7/SCN9A with high potency (IC(50)=117 nM) and Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.6/SCN8A and Nav1.5/SCN5 with weaker potency. Also inhibits voltage-gated calcium channel Cav3.1/CACNA1G, Cav3.2/CACNA1H and Cav3.3/CACNA1I.
Subcellular location: Secreted {ECO:0000269|PubMed:28542706}.
Interaction partners:
Sequence:
ECRWFLGGCSGGQTCCEHLVCHRKHQWCVWDWSF