wanglab/gogpt-training-data huggingface dataset:
Protein: Phospholipid-transporting ATPase tat-1 (TAT-1) (EC 7.6.2.1) (Q9U280)
Organism: Caenorhabditis elegans
Function: Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet. Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes. Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintenance and control of the membrane surface charge. Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo, likely with its chaperone protein chat-1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18436785}; Multi-pass membrane protein {ECO:0000269|PubMed:18436785}. Early endosome membrane {ECO:0000269|PubMed:21170358}; Multi-pass membrane protein. Recycling endosome membrane {ECO:0000269|PubMed:21170358}; Multi-pass membrane protein. Note=Colocalizes with its chaperone chat-1 at apical and basolateral cell membranes, on early endosomes and on recycling endosomes. Also localizes to intracellular tubular and vesicular structures. {ECO:0000269|PubMed:21170358}.
Interaction partners:
Sequence:
MPTEARDNNRHIHLGKVRDPHHQHAQRFCSNRISTCKYNGFSFLPRFLYEQFRRYNNIFFLAIALLQQIPDVSPTGRYTTAVPFLIILSVSALKEIFEDVKRRRSDNKVNAFSVEILVDGHWIEKQWKDVSVGDFIRIDNDSLFPADLLLLASSEQQGMAYIETSNLDGETNLKIKQALDITSTMTSPEKLSQFESEITCEPPSRHVNEFNGNIEINGVARHFGIDQLLLRGARLKNTAWIFGAVIYTGHDSKLLMNSKRAPLKSGTIDVQTNYRIIFLFFVLVALALISATGSEIWRGNNIPQAWYLSFLEHDPKGSFLWGVLTFFILYNNLIPISLQVTLEVVRFFQAIYINNDIEMYDVNSDSCAIARTSNLNEELGQVKFIMSDKTGTLTRNVMKFKRLSIGSRNYGNNEDDEFADASLIEDYRQGDEHSTSILEVLKMMAVCHTVVPENKDGQLIYQSSSPDEAALVRGAASQSVSFHTRQPQKVICNVFGEDETIEILDVIDFTSDRKRMSVIVRDGAGGDIKLYTKGADTVIFERLEHGKEQEEAVEYCTEHLEDYASFGYRTLCFSMRHLTEQEYSQWAPEYKKAILAIDNRAKLLADAAEKLERNMILVGATAIEDKLQEWVPETIQALMAADIRVWMLTGDKRETAINIAHSCALCHTNTELLIVDKTTYEETYQKLEQFVARAIELEKQEKGFAMVIDGKSLLHALTGEARKHFGDLALRCHAVVCCRMSPMQKAEVVEMVRKLAKHVVLAIGDGANDVAMIQAANVGVGISGEEGLQAASASDYAIPRFHFLRRLLLVHGAWNHDRSVKVILYSFYKNICLYIIELWFAMFSAWSGQTIFERWTIGMFNVIFTAWPPVVLGLFDHPVPAEQIMKYPALYASFQNRAFSIGNFSLWIGLAIVHSLSLFFLTYATMEHQVVWDNGLTGGWLMLGNCAYTFVVATVCFKALLECDSWTWPVVVACIGSIGLWIVFVIVYSLVFPHIGGIGADMAGMAAIMMSSYTFWLALLFIPLATLLWDLVIKSLFTIAMPTPRELAVMYNKRTTSFNGFERLASYSSNVLENMRLLTSSLRGSTTGSTRSRTASEASLALAEQTRYGFAFSQDESSAVAQTELIRNVDSTREKPTGR
Protein: Pre-mRNA cleavage factor Im 25 kDa subunit 1 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (AtCFI-25) (CFIm-25) (CPSF 25 kDa subunit) (Cleavage and polyadenylation specificity factor subunit 25) (Q94AF0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O43809}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. {ECO:0000250|UniProtKB:O43809}.
Interaction partners:
- FIP1[V]-like protein
- Cleavage stimulation factor subunit 50
- 30-kDa cleavage and polyadenylation specificity factor 30
- HEAT repeat-containing protein
- Cleavage stimulating factor 64
- Cleavage stimulation factor subunit 77
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 1
- Symplekin
- Polyadenylate-binding protein 1
Sequence:
MGEEARALDMEEISDNTTRRNDVVHDLMVDLYPLSSYYFGSKEALRVKDEIISDRVIRLKSNYAAHGLRTCVEAVLLVELFKHPHVLLLQYRNSIFKLPGGRLRPGESDIEGLKRKLASKLSVNENVGVSGYEVGECIGMWWRPNFETLMYPFLPPNIKHPKECTKLFLVRLPVHQQFVVPKNFKLLAVPLCQLHENEKTYGPIMSQIPKLLSKFSFNMMEI
Protein: ADP-ribosylation factor GTPase activating protein 1, putative (Q381Z1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- ADP-ribosylation factor GTPase activating protein, putative
- ADP-ribosylation factor GTPase activating protein, putative
- SEC7 domain-containing protein
- Coatomer subunit gamma
- Coatomer subunit epsilon
- Coatomer subunit beta'
- ER lumen protein-retaining receptor
- Coatomer subunit delta
- Coatomer subunit beta
- Coatomer subunit alpha
Sequence:
MSHTAEDARVFREILQRDEECKHCFECGALSPQWCDVNHGVFVCLDCSGVHRSLGVHLSFVRSPTMDGWTNWRPEKLRQMQIGGNRRAREYFERNGVPKAPIRERYQSLGALRYGAMLEAEALGQPFDESSWAPPEWYERMVQSERNRPNGEGMPPQAPQQHRPINGMWGEGHGSTGSGGGKEWLDTLSGGWSVFSKKTKEIAETAGAQARSLITETNVEGVKGTLASGWGAISGFATQMSSKLLNKNQEDDLSVLSDMTQHVKTAVQDDNQGLVGRNMTQSHSEVGNAAFKGQANPYDGDFQSKKD
Protein: ABC transporter, permease protein, putative (Q881L3)
Organism: Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- ABC transporter, ATP-binding protein
- PpkA-related protein
- Sulfatase-modifying factor enzyme-like domain-containing protein
- HopL1 protein
- Uncharacterized protein
- Virulence factor SrfB
- Virulence factor
- VWFA domain-containing protein
- Pyoverdine export ATP-binding/permease protein PvdT
- Probable syringafactin export ATP-binding/permease protein SyfD
Sequence:
MNRPFKRLGLLARLAIADLWHDRKVSLCIAASLVAVIAPLLLLFGLKHGVVGQLQAELLRDPRNLEIKLLSSGNYDEQWLNRLQQRPETGFALGMTRSLNTQADLIGSRGRFVDNAEILPTGPGDPLLAAQAMAILPGQVILSNAAAERLALVPGDTLRLAVQRRLDGAPERGETTLTLVAVLPAARFSRPAAFAHPDLLLQLEHFRDGFAISALGATRGQAEDQLAPRYARARLYARDIDSVAPLERWLNEQHIETGSRLADIDNVKAINHVLSVIFGVIAGAALLGCIASLIGAFLANIDRKRRSLALLRLMGFTAPAVAGYLVLQALLLAVVGYVGGLGFYFAGSEAFNHLLGGQRITGGFICQITPLHGLAALALALVVSALVALAGATRAIRIQPAESLREL
Protein: Sorting nexin-3 (Protein SDP3) (O60493)
Organism: Homo sapiens (Human)
Function: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs.
Subcellular location: Early endosome {ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:30213940}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:23237080}. Note=Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures (PubMed:21725319) Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (PubMed:23237080). In the case of Salmonella enterica infection localizes to Salmonella-containing vacuoles (SCVs) from which SNX3-containing tubules form 30-60 minutes after infection (PubMed:20482551). {ECO:0000269|PubMed:20482551, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080}.
Interaction partners:
- Vacuolar protein sorting-associated protein 26A
- Vacuolar protein sorting-associated protein 35
- Vacuolar protein sorting-associated protein 29
- Sorting nexin-6
- Vacuolar protein sorting-associated protein 26B
- Sorting nexin-5
- Sorting nexin-12
- Sorting nexin-27
- Protein wntless homolog
- TBC1 domain family member 5
Sequence:
MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
Protein: Membrane magnesium transporter 2 (Q8R3L0)
Organism: Mus musculus (Mouse)
Function: Mediates Mg(2+) transport.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18057121}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:18057121}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 3
- Endoplasmic reticulum membrane protein complex subunit 7
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 8
- ER membrane protein complex subunit 9
- Predicted gene, 27021
Sequence:
MVAWLWKVLMGVGLFALTHAAFSAAQHRSHARLTEKKYEPLPADIVLQTLLAFALTCYGVVHTAGDFRDRDATSELKDMTFDTLRNRPSFYVFHRSGYRLFQRPDSTHSSNLSASSSDLPLKF
Protein: Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (SND p102) (p100 co-activator) (p105 coactivator) (Q66X93)
Organism: Rattus norvegicus (Rat)
Function: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q7KZF4}. Nucleus {ECO:0000250|UniProtKB:Q7KZF4}. Melanosome {ECO:0000250|UniProtKB:Q7KZF4}. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. {ECO:0000250|UniProtKB:Q7KZF4}.
Interaction partners:
- Protein LYRIC
- Protein argonaute-2
- Signal transducer and activator of transcription
- Fragile X messenger ribonucleoprotein 1
- Neutral alpha-glucosidase AB
Sequence:
MASAQSSGSSGGPAVPTVQRGIVKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLARRAAATQPDGKDTPDEPWAFPAREFLRKKLIGKEVCFTIENKTPQGREYGMIYLGKDTNGENIAESLVAEGLASRREGMRANNPEQNRLSECEEQAKASKKGMWSEGNGSHTIRDLKYTIENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPDHYLVTVMLSGIKCPTFRRETDGSETPEPFAAEAKFFTESRLLQRDVQIILESCHNQNILGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLRAAERFAKERRLRIWRDYVPPTANLDQKDKQFVAKVMQVLNADAIVVKLNSGDYKTIHLSSIRPPRLEGDNIQDKNKKLRPLYDIPYMFEAREFLRKKLIGKKVSVTVDYIRPASPATETVPAFSERTCATVTIGGINIAEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKKEVPIHRVADISGDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGARNLPGLVQEGEPFSEEATLFTKELVLQREVEVEVESMDKAGNFIGWLHMDGANLSVLLVEHALSKVHFTAERSAYYKPLLSAEEAAKQRKEKVWAHYEEQPVEEVMPVLEEKERSASYKPVFVTEITDDLHFYVQDVETGTQLEKLMENMRSDISSHPPVEGAYAPRRGEFCIAKFVDGEWYRARVEKVESPAKVHVFYIDYGNREILPSTRLGALPPAFSTRVLPAQATEYAFAFIQVPQDEDARTDAVDSVVRDIQNTQCLLNVEHLSASCPHVTLQFADSKGDVGLGLVKEGLVMVEVRKEKQFQKVITEYLNAQESAKSARLNLWRYGDFRADDADEFGYSR
Protein: F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) (O94868)
Organism: Homo sapiens (Human)
Function: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q3USJ8}. Cell junction {ECO:0000269|PubMed:14627983}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. Cell membrane {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}; Peripheral membrane protein {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:30249660}; Cytoplasmic side {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:30249660}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3USJ8}. Note=Partially localized at clathrin-coated pits at the cell membrane (PubMed:30249660). Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits (PubMed:29887380). Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions (PubMed:14627983). {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.
Interaction partners:
- Intersectin-1
- Actin nucleation-promoting factor WASL
- SH3 and cysteine-rich domain-containing protein
- E3 ubiquitin-protein ligase TRIM45
- Spartin
- Actin nucleation-promoting factor WAS
- Sorbin and SH3 domain-containing protein 1
- PDZ domain-containing protein 7
- Sorting nexin-16
- Killer cell immunoglobulin-like receptor 3DL1
Sequence:
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYDQPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKLRPVRAAPPPPTQNHRRPAEKIEDVEITLV
Protein: Multistep phosphorelay regulator 1 (O94321)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds to the msc4 response regulator which is part of a multistep phosphorelay system that transmits oxidative stress signals to the spc1 MAPK cascade.
Interaction partners:
- Response regulator mcs4
- Transcription factor prr1
- Peroxide stress-activated histidine kinase mak2
- Peroxide stress-activated histidine kinase mak3
- Peroxide stress-activated histidine kinase mak1
- Protein kinase wis1
- Mitogen-activated protein kinase sty1
- MAP kinase kinase kinase wis4
- N-acetyltransferase aca1
- MAP kinase kinase kinase win1
Sequence:
MSVYRDNMYMKYDRNFENRVARRNGQARNASLAKTLHDSGIAERARSPSGSAIPHAYRVMNGSGANDTSLPLTSNPAYVALTSRISSSKSENNQQLAANETAGAPEGTEETVDISNSISDDHANAKNLPAASVKALVGAGVLSDELSVIAYDMSFEDELIQDKQLIDHSVFDQLLEMDDDDEHEFSKSIVWNYFEQAETTIADLQKALEAKDLKKLSSLGHFLKGSSAVLGLTKMRKVCERIQNYGSLRSRDGVMKLPSEEIALDLISKSLSVVNDFYKDARAYLLDFYEKNSST
Protein: Uncharacterized protein (Q9XVX8)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- histone acetyltransferase
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 9
- Transcription-associated protein 1
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 10
- SANT domain-containing protein
- Nuclear receptor corepressor 1
- TATA-box-binding protein
- TATA box-binding protein-like 1
Sequence:
MPPKRAVKKKVQTTEKARPTLDQEIKLDDSNELEPSIRSVVTSLMFTSGDDENPLSENEDFVVNILKNELVLFINDVIEVYDNKIPNVKLQHMLQLLNSQKGVLSRFIKYLKNRVEMSAFMRAKSFSKNGTENICGQEVENEDETTDEKIEEGVDPMDEIGEVGGEEGEYLKNKRRTYGTITSEENLLQEAQKSFFDAGLDFNTFENDVDENHNQQLIVLQTILEDMNADEYSRFALARRVSFQNQSAVPVVYSDTFSKSNARKRKRSPPTNNRQLLLQWLGNPPVHDESAQVFLAFLAKDIISEIVGNALLERRKMNPAEGGPLSYSYYEEPLRRNRKFRKYGRILI
Protein: Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (GGTase-II-alpha) (Geranylgeranyl transferase type II subunit alpha) (PGGT) (Type II protein geranyl-geranyltransferase subunit alpha) (YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha) (Q00618)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta
- Rab proteins geranylgeranyltransferase component A
- Synaptobrevin homolog YKT6
- Protein farnesyltransferase subunit beta
- GTP-binding protein YPT1
- Ras-related protein SEC4
- Ypt/Rab-type GTPase YPT7
- Suppressor of kinetochore protein 1
- Vacuolar protein sorting-associated protein 21
Sequence:
MHGIKRKQWTKELLRQKRVQDEKKIYDYRSLTENVLNMRDEKIYSIEALKKTSELLEKNPEFNAIWNYRRDIIASLASELEIPFWDKELVFVMMLLKDYPKVYWIWNHRLWVLKHYPTSSPKVWQTELAVVNKLLEQDARNYHGWHYRRIVVGNIESITNKSLDKEEFEYTTIKINNNISNYSAWHQRVQIISRMFQKGEVGNQKEYIRTEISYIINAMFTDAEDQSVWFYIKWFIKNDIVCKTLDEQEYLKMLKDLRENILLINNDEIEFSGKQNIWCLKILLVLEDILEEKEALTERSSEQYLVQLIDADPLRKNRYLHLLEQHK
Protein: 60S ribosome subunit biogenesis protein NIP7 homolog (Q6NM52)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- AT5g04600/T32M21_200
- Ribosome assembly factor mrt4
- Ribosome biogenesis protein WDR12 homolog
- At4g01560
- Probable rRNA-processing protein EBP2 homolog
- Pescadillo homolog
- Probable ribosome biogenesis protein RLP24
- Ribosome biogenesis protein BOP1 homolog
- Ribosome production factor 2 homolog
- Protein MAK16 homolog
Sequence:
MRPLDETETTVVFEKLFKFVGNNLKKIVENPSDEGPESTPGSYCFRLQKNRVYYVSEALVKRATNISRKNLVSFGTCIGKYTHAGSFHLTIMSLNILAANAKHKVWLKPTSEMSFLYGNHVLKGGLGRITDSIVPGDGVVVFSMSDVPLGFGIAAKSTQDCRKLDPNGIVVLHQADIGEYLRGEDDL
Protein: HCLS1 associated protein X-1 (E9PIQ7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLKYPDSHQPRIFGGVLESDARSESPQPAPDWGSQRPFHRFDDVWPMDPHPRTREDNDLDSQVSQEGLGPVLQPQPKSYFKSISVTKITKPDGIVEERRTVVDSEGRTETTVTRHEADSSPRGDPESPRPPALDDAFSILDLFLGRWFRSR
Protein: Breast cancer resistance protein (A8IJF9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSQPLNSQIPGMEDTKTNGTPKYESTGTAKSLQGSTVSFHNIHYKVTQRSGCLCIKRKTTTKDILIDLNGLMKPGLNAIMGATGSGKSSFLDVLAARKDPAGLAGEVLMDGAPQPPNFKCLSGYVVQDDVVLGTLTVRENFRFSAALRLPSSVSQKEKEDKVNRLITELGLTKVADSRVGTQLIRGISGGERKRTNIGMELIIDPPVLFLDEPTTGLDASTANSVLLLLKRMSSHGRTIILSIHQPRYSIFRLFDSLTLLVSGKQVYHGPAQSALDYFSNIGYTCEPHNNPADFFLDVINGDSTSIAFDRIKEADDSDPDRVTSSKQNIEDHLVQEYRGSQYLGETKAQLERITMTKEYGWKTPSRTIRYNTSFSTQFRWVLKRTFTNLILNPQTSFAQIGVTVFLALIVGAIFFGVKNDQSGLQNRMGALFFITTNQCFSSLSSAELFITERKLFIHEYISGYYRVSVYFLCKILSDIITLRTLPSIVFSCVAYFMIGYKATVEAFFLFMLTVALVAYTATAMTMAISADQSVVAIANIFMTIAFVFMMIFSGLLVNLPSIVEWLAWFQYLSIPRYGLTALQINEFVGLQFCGDIPLNGTLPPGMTCTGEDFLKNQGIDYTTWGLWQNHVALAIMTVIFLLIAYFKLRFIKKFT
Protein: Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) (P16331)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine.
Interaction partners:
- Pterin-4-alpha-carbinolamine dehydratase
- Sepiapterin reductase
- Dihydropteridine reductase
- Tyrosine aminotransferase
- Pterin-4-alpha-carbinolamine dehydratase 2
- Aromatic-L-amino-acid decarboxylase
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Putative aspartate aminotransferase, cytoplasmic 2
- Dihydrofolate reductase
Sequence:
MAAVVLENGVLSRKLSDFGQETSYIEDNSNQNGAVSLIFSLKEEVGALAKVLRLFEENEINLTHIESRPSRLNKDEYEFFTYLDKRSKPVLGSIIKSLRNDIGATVHELSRDKEKNTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEERKTWGTVFRTLKALYKTHACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEGDSIKAYGAGLLSSFGELQYCLSDKPKLLPLELEKTACQEYTVTEFQPLYYVAESFNDAKEKVRTFAATIPRPFSVRYDPYTQRVEVLDNTQQLKILADSINSEVGILCHALQKIKS
Protein: Protein YAE1 (P47118)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The complex LTO1:YAE1 functions as a target specific adapter that recruits apo-RLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein LTO1
- Translation initiation factor RLI1
- Cytosolic Fe-S cluster assembly factor CFD1
- Cytosolic Fe-S cluster assembly factor NBP35
- NADPH-dependent diflavin oxidoreductase 1
- Fe-S cluster assembly protein DRE2
- DNA repair/transcription protein MET18/MMS19
- Cytosolic Fe-S cluster assembly factor NAR1
Sequence:
MSNTWDDVWASDSDVETERSPDLVKLRENHSKRGYLDGIVSSKEEKLQEGFNDGFPTGAKLGKQVGIIMGILLGLRTRFGDEDEDLSKAYIDAQKELRINKVLSKSIFDPNFDLQEKHPLITKWTDIANTYCEKYHVPSIQ
Protein: Endo-1,4-beta-xylanase C (Xylanase C) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase C) (34 kDa xylanase) (Xylanase X34) (Q00177)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular location: Secreted {ECO:0000269|PubMed:25043916}.
Interaction partners:
- Endo-1,4-beta-xylanase B
- Xylanolytic transcriptional activator xlnR
- Endo-1,4-beta-xylanase A
- Exo-1,4-beta-xylosidase xlnD
- Probable alpha-L-arabinofuranosidase A
- Probable D-xylulose reductase A
- Probable alpha-L-arabinofuranosidase axhA-1
- Alpha-L-arabinofuranosidase B
- Alpha-L-arabinofuranosidase axhA-2
- Alpha-glucuronidase A
Sequence:
MVHLKTLAGSAVFASLATAAVLPRQSASLNDLFVAAGKSYFGTCSDQALLQNSQNEAIVASQFGVITPENSMKWDALEPSQGNFGWSGADYLVDYATQHNKKVRGHTLVWHSQLPSWVSSIGDANTLRSVMTNHINEVVGRYKGKIMHWDVVNEIFNEDGTFRNSVFYNLLGEDFVRIAFETARAADPDAKLYINDYNLDSASYAKTQAMASYVKKWLAEGVPIDGIGSQAHYSSSHWSSTEAAGALSSLANTGVSEVAITELDIAGAASSDYLNLLNACLNEQKCVGITVWGVSDKDSWRASDSPLLFDGNYQPKDAYNAIVNALS