wanglab/gogpt-training-data huggingface dataset:
Protein: Spindle pole body component SPC98 (P53540)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB.
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Interaction partners:
- Spindle pole body component 110
- Spindle pole body component SPC97
- Gamma tubulin complex adapter SPC72
- Tubulin gamma chain
- DASH complex subunit ASK1
- Spindle pole body component SPC42
- Cell division control protein KAR1
- Cell division control protein 31
- DASH complex subunit DAD2
- DASH complex subunit DAD3
Sequence:
MELEPTLFGIIEALAPQLLSQSHLQTFVSDVVNLLRSSTKSATQLGPLIDFYKLQSLDSPETTIMWHKIEKFLDALFGIQNTDDMVKYLSVFQSLLPSNYRAKIVQKSSGLNMENLANHEHLLSPVRAPSIYTEASFENMDRFSERRSMVSSPNRYVPSSTYSSVTLRQLSNPYYVNTIPEEDILKYVSYTLLATTSALFPFDHEQIQIPSKIPNFESGLLHLIFEAGLLYQSLGYKVEKFRMLNISPMKKALIIEISEELQNYTAFVNNLVSSGTVVSLKSLYREIYENIIRLRIYCRFTEHLEELSGDTFLIELNIFKSHGDLTIRKIATNLFNSMISLYYEYLMNWLTKGLLRATYGEFFIAENTDTNGTDDDFIYHIPIEFNQERVPAFIPKELAYKIFMIGKSYIFLEKYCKEVQWTNEFSKKYHVLYQSNSYRGISTNFFEIINDQYSEIVNHTNQILNQKFHYRDVVFALKNILLMGKSDFMDALIEKANDILATPSDSLPNYKLTRVLQEAVQLSSLRHLMNSPRNSSVINGLDARVLDLGHGSVGWDVFTLDYILYPPLSLVLNVNRPFGRKEYLRIFNFLWRFKKNNYFYQKEMLKSNDIIRSFKKIRGYNPLIRDIINKLSRISILRTQFQQFNSKMESYYLNCIIEENFKEMTRKLQRTENKSQNQFDLIRLNNGTIELNGILTPKAEVLTKSSSSKPQKHAIEKTLNIDELESVHNTFLTNILSHKLFATNTSEISVGDYSGQPYPTSLVLLLNSVYEFVKVYCNLNDIGYEIFIKMNLNDHEASNGLLGKFNTNLKEIVSQYKNFKDRLYIFRADLKNDGDEELFLLSKSLR
Protein: Protein OSB2, chloroplastic (Organellar single-stranded DNA-binding protein 2) (Protein FLORAL ABSCISSION ASSOCIATED) (Protein PLASTID TRANSCRIPTIONALLY ACTIVE 9) (Q8GXH3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds preferentially single-stranded DNA. Does not bind to RNA.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:17189341}.
Interaction partners:
- Single-stranded DNA-binding protein WHY3, chloroplastic
- Single-stranded DNA-binding protein WHY2, mitochondrial
- Single-stranded DNA-binding protein
- AT4g27390/M4I22_200
- Membrane lipoprotein lipid attachment site-like protein, putative
- AT4g27380/M4I22_190
- AT4g20040/F18F4_140
- DNA repair protein recA homolog 1, chloroplastic
- Non-canonical heme oxygenase HOZ, chloroplastic
- MutS2
Sequence:
MSLISKSLARIECSPFFYPRASEITTGKRITSPQIRLYTAAAVGGKTGNGERKQRAKAPAKTPEAVTPVKPLEIASVTATTENELPRPNEIAYESEVANWVNLIGFVDQPVQFEASSDGKFWAGTVISQRSASDSSGFWIPIIFEGDLAKTAARYVSKDDQIHVSGKLFIDSPPPNMTYAQANVQVLVQNLNFIQPMSPSPSPFMVMSSSEKEESGIKKQPARAKQDIVIDEASDSWNHLIENPKEWWDHRENKVNGLVKPRHPDFKSKDSSFSLWLNKAPNWVLPKLEGLEFDVLVPKARVVKQLKGEESWKDLVQNPDKWWDNRIDKRNAKAPDFKHKETGEALWLNESPTWVLPKLPPVKKKQESIVF
Protein: Nuclear factor 1 (A0A286YEX4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
Sequence:
MEVPGPPVSSKPGETSVKWQLCYDTTAKMWWMDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQAQSWYLG
Protein: Pescadillo homolog (O00541)
Organism: Homo sapiens (Human)
Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255|HAMAP-Rule:MF_03028}.
Interaction partners:
- Nucleolar complex protein 2 homolog
- GTP-binding protein 4
- Ribosome biogenesis protein WDR12
- mRNA turnover protein 4 homolog
- Ribosome biogenesis protein NSA2 homolog
- Ribosome biogenesis protein BOP1
- Probable rRNA-processing protein EBP2
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- Guanine nucleotide-binding protein-like 3
- WD repeat-containing protein 74
Sequence:
MGGLEKKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFMHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLHYPPKLEGQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEFPTDGEMSAQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLPPHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE
Protein: Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (D4A9W8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR038005}.
Interaction partners:
- Single-strand selective monofunctional uracil-DNA glycosylase
- G/T mismatch-specific thymine DNA glycosylase
- DNA
- DNA
- DNA mismatch repair protein Mlh1
Sequence:
SAERAGTQEAEAKEDVAVGLGGVGEDGKDLVISSECGSLLQEPAASTLPSCTTVAECHKPVPCGWERVVKQRLSGKTAGRVDVYFISPQGSKFRSKRSLANYLLKTGETCLKPEDFDFTVLSKGGINPGYKHQSLSAPASQQPNEADISKLNLRTRSKWKTDVLPLPGGNSESPDSNSLSNSNSARLLLKEHKGIQDADSGKSRKPKIKVTVLKGIASQRTKQRCRKSPSDSTGRNRKRLCTVQKADTDSELVPQESRLHRTVCPADACARATVSLVREAKGLGEEKSPSSDLRFTQVTSSITNKLYSTEAAGEATREATREQTFLESEEIRSKGEEEEAHLHIDILQSGSETPSCSQAKKHLTSETFREDSIPRTQVEKRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLISTIFLNRTSGKMAIPVLWEFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIIKFSDEYLTKPWRYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLSLS
Protein: ATP synthase subunit beta, mitochondrial (EC 7.1.2.2) (P17614)
Organism: Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular location: Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
Interaction partners:
Sequence:
MASRRLLASLLRQSAQRGGGLISRSLGNSIPKSASRASSRASPKGFLLNRAVQYATSAAAPASQPSTPPKSGSEPSGKITDEFTGAGSIGKVCQVIGAVVDVRFDEGLPPILTALEVLDNQIRLVLEVAQHLGENMVRTIAMDGTEGLVRGQRVLNTGSPITVPVGRATLGRIINVIGEAIDERGPITTDHFLPIHREAPAFVEQATEQQILVTGIKVVDLLAPYQRGGKIGLFGGAGVGKTVLIMELINNVAKAHGGFSVFAGVGERTREGNDLYREMIESGVIKLGEKQSESKCALVYGQMNEPPGARARVGLTGLTVAEHFRDAEGQDVLLFIDNIFRFTQANSEVSALLGRIPSAVGYQPTLATDLGGLQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRQISELGIYPAVDPLDSTSRMLSPHILGEDHYNTARGVQKVLQNYKNLQDIIAILGMDELSEDDKMTVARARKIQRFLSQPFHVAEVFTGAPGKYVDLKESINSFQGVLDGKYDDLSEQSFYMVGGIDEVIAKAEKIAKESAA
Protein: F-box only protein 9 (Q8BK06)
Organism: Mus musculus (Mouse)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UK97}.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
- F-box only protein 4
- Cullin-3
Sequence:
MSAEAEEDCHSDADRVGDEGNESPAERDLQAQLQMFRAQWMFELTPGVGSSHGETRPCRAGRSSMLKAAADTKGRQELAKEEKARELFLQAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSGYIEENEDASKMADLLSYFQQQLTLQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVPYASWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYMRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTDAILLGHYRLSQDADNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQEADHSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKATGETAVSAFEIDKMYTPLLFARVRSYTAFSERPL
Protein: TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) (Q15714)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21791611}. Nucleus {ECO:0000250|UniProtKB:P62500}. Cell membrane {ECO:0000269|PubMed:21791611}; Peripheral membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:34681573}. Nucleus {ECO:0000269|PubMed:34681573}. Mitochondrion {ECO:0000269|PubMed:34681573}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:34681573}. Nucleus {ECO:0000269|PubMed:34681573}. Mitochondrion {ECO:0000269|PubMed:34681573}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:34681573}. Nucleus {ECO:0000269|PubMed:34681573}.
Interaction partners:
- Nuclear receptor-binding protein
- TSC22 domain family protein 4
- TSC22 domain family protein 3
- Low-density lipoprotein receptor class A domain-containing protein 4
Sequence:
MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGSGSASALNAAGTGVGSNATSSEDFPPPSLLQPPPPAASSTSGPQPPPPQSLNLLSQAQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASITGGPPSSPVSRKLSTTGSSDSITPVAPTSAVSSSGSPASVMTNMRAPSTTGGIGINSVTGTSTVNNVNITAVGSFNPNVTSSMLGNVNISTSNIPSAAGVSVGPGVTSGVNVNILSGMGNGTISSSAAVSSVPNAAAGMTGGSVSSQQQQPTVNTSRFRVVKLDSSSEPFKKGRWTCTEFYEKENAVPATEGVLINKVVETVKQNPIEVTSERESTSGSSVSSSVSTLSHYTESVGSGEMGAPTVVVQQQQQQQQQQQQQPALQGVTLQQMDFGSTGPQSIPAVSIPQSISQSQISQVQLQSQELSYQQKQGLQPVPLQATMSAATGIQPSPVNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYGQQQPMVSTQMAPGHVKSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAVPAQPAGASVQPVGQAPAAVSAVPTGSQIANIGQQANIPTAVQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQPQGVEPVAQGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSAQSLAQAIGSQIEDARRAAEPSLVGLPQTISGDSGGMSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDESSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGPTA
Protein: Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein) (Q9UK39)
Organism: Homo sapiens (Human)
Function: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Represses translation and promotes degradation of target mRNA molecules. Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O35710}. Nucleus {ECO:0000250|UniProtKB:O35710}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O35710}. Mitochondrion {ECO:0000269|PubMed:31147539}.
Interaction partners:
- Basic helix-loop-helix ARNT-like protein 1
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 8
- Circadian locomoter output cycles protein kaput
- CCR4-NOT transcription complex subunit 2
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 4
- Probable ATP-dependent RNA helicase DDX6
Sequence:
MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASAASGAARSCSRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHTRPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDFSFTEESDGLS
Protein: Calcium channel, voltage-dependent, alpha 1I subunit (F6TAX9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XPRMPTSSPGAPGRGSGGAGVGGDTESHLCRHCYSPAQDSLEGELTIIDNLSGSIFHHYSSPAGCDKCHHDKQEGPVAQRSRPRLPHPSPRVTRGHHLPPQVQLAETEAFSLNSDRSSSVLLGDDLSLEDPT
Protein: Translationally-controlled tumor protein homolog (TCTP) (Q93573)
Organism: Caenorhabditis elegans
Function: Involved in calcium binding and microtubule stabilization.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Large ribosomal subunit protein uL10
- Probable elongation factor 1-gamma
- Probable elongation factor 1-beta/1-delta 1
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein uL6
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein P1
Sequence:
MLIYKDIFTDDELSSDSFPMKLVDDLVYEFKGKHVVRKEGEIVLAGSNPSAEEGAEDDGSDEHVERGIDIVLNHKLVEMNCYEDASMFKAYIKKFMKNVIDHMEKNNRDKADVDAFKKKIQGWVVSLLAKDRFKNLAFFIGERAAEGAENGQVAIIEYRDVDGTEVPTLMLVKEAIIEEKC
Protein: Histone H2A.Z (H2A/z) (P0C0S7)
Organism: Rattus norvegicus (Rat)
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H3.3
- Histone H4
- Vacuolar protein sorting-associated protein 72 homolog
- Histone H3.1
- Histone H3
- Histone H3
- Similar to centromere protein A
- Histone deacetylase 2
- Snf2-related CREBBP activator protein
- Histone deacetylase 1
Sequence:
MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV
Protein: S100P-binding protein (S100P-binding protein Riken) (Q96BU1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:15632002}. Note=Colocalizes with S100P in the nucleus. {ECO:0000269|PubMed:15632002}.
Interaction partners:
- Protein S100-P
Sequence:
MMCSRVPSEQSSGTSLLPKDGAPFSWDSLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSGEDDGGHVEKGERGSQILLDTPREKNSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVTVAPFNPTVCDALLDKDETDSSKDTEKLSSLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSSSNNNFQQTVSDKNMPDSENPTSVFSRISDHSETPNMELSCRNGGSHKSSCEMRSLVVSTSSNKQDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIEDPEDTNQGISGELCALMDQVHHMQHSKWQHPSDLTTRNYARRQKHLQRYSLTQWVDRNMRSHHRFQRLPDFSYS
Protein: Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) (P00572)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the conversion of dTMP to dTDP.
Interaction partners:
- Thymidylate synthase
- Nucleoside diphosphate kinase
- Uridylate kinase
- Deoxycytidylate deaminase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Ribonucleoside-diphosphate reductase large chain 1
- Ribonucleoside-diphosphate reductase large chain 2
- Ribonucleoside-diphosphate reductase small chain 1
- Ribonucleoside-diphosphate reductase small chain 2
- DNA ligase 1
Sequence:
MMGRGKLILIEGLDRTGKTTQCNILYKKLQPNCKLLKFPERSTRIGGLINEYLTDDSFQLSDQAIHLLFSANRWEIVDKIKKDLLEGKNIVMDRYVYSGVAYSAAKGTNGMDLDWCLQPDVGLLKPDLTLFLSTQDVDNNAEKSGFGDERYETVKFQEKVKQTFMKLLDKEIRKGDESITIVDVTNKGIQEVEALIWQIVEPVLSTHIDHDKFSFF
Protein: BcDNA.GH07910 (Tousled-like kinase, isoform F (EC 2.7.11.1)) (Tousled-like kinase, isoform H) (Tousled-like kinase, isoform J) (Q9W4Q4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDQFQTSLNPRKLELLESRITGVRMSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS
Protein: Tetrahydromethanopterin S-methyltransferase subunit F (EC 7.2.1.4) (N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit F) (Q50773)
Organism: Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Tetrahydromethanopterin S-methyltransferase subunit A 1
- Tetrahydromethanopterin S-methyltransferase subunit B
- Tetrahydromethanopterin S-methyltransferase subunit E
- Tetrahydromethanopterin S-methyltransferase subunit H
- Tetrahydromethanopterin S-methyltransferase subunit C
- Tetrahydromethanopterin S-methyltransferase subunit G
- Tetrahydromethanopterin S-methyltransferase subunit D
- Tetrahydromethanopterin S-methyltransferase subunit A 2
- Formylmethanofuran--tetrahydromethanopterin formyltransferase-like protein
- Bifunctional enzyme Fae/Hps
Sequence:
MIILSNKPNIRGIKNVVEDIKYRNQLIGRDGRLFAGLIATRISGIAIGFLLAVLLVGVPAMMSILGVI
Protein: Protein kinase C (EC 2.7.11.13) (L7RSM7)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004318}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004318}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
Protein: Probable N-acetyltransferase family 8 member 5 (EC 2.3.1.-) (Camello-like protein 5) (Probable N-acetyltransferase CML5) (Q9QXS8)
Organism: Mus musculus (Mouse)
Function: May play a role in regulation of gastrulation.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytosol aminopeptidase
- Aminopeptidase N
- N-acetyltransferase 8
Sequence:
MAPYQIRQYQERDYKLVVGLFSRGMMEHIPAAFRYTLLLPQTLLFLFVMPLTIVLVFGSWLLAVICIFFLLLLLRLLAGQPFKDYVAQCLQTDMADITRSYLNAHGSFWVAESGGLVVGTVGGLPVKDPPLGRKQMQLFHLSVSSQHRGQGIAKALVRTVFQFARDQGYSDVVLETSVIQQSAITLYEAMGFQRTGKYSEISIIKWLITFSIIHFTYSFPSTQKHEL
Protein: At5g12410 (THUMP domain-containing protein) (Q94CK1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT3g07170/T1B9_17
- La protein 1
- Uncharacterized protein At2g34160
- Protein EMBRYO DEFECTIVE 514
- Nucleic acid-binding, OB-fold-like protein
- Alba DNA/RNA-binding protein
- Single-stranded DNA-binding protein
- Pre-mRNA cleavage factor Im 25 kDa subunit 2
- DEAD-box ATP-dependent RNA helicase 46
- ARM repeat superfamily protein
Sequence:
MASGDQSKKRKQHYRPQNRPVKKKGSYPLKPGVQGFFISCDGGREFQAAQEAINVIDSFFEELIQGTDSKVNPGLFGNPINKKVTFSYSEDEDEEEDESNNGEEEENKGDGDKAVVSEGGNDLVNEKEIASEGVNDQVNEKEIASEGSCEVKQLAENETVKEEEDKGNQKNGGDEPPRKKTCTEEANPLAKVNENAEKSIDKLIEAELKELGDKSKRRFMKLDPGCNGLVFIQMKKRDGDPSPKEIVQHAMTSAAATKKHMSRFILRLLPIEVSCYPSEEEISRAIKPLVEQYFPIETENPRKFAVLYGARANTGLDRMKIINTIAKSIPAPHKVDLSNPEMTIVVEIIKTVCLIGVVEKYKELAKYNLRQLTSTN
Protein: Small ribosomal subunit protein uS13m (37S ribosomal protein subunit sws2, mitochondrial) (O59772)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- mRNA export factor elf1
- Elongation factor 3
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein bS6m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS11m
Sequence:
MVYILGVAVNDDKPVRFALLSFYGIGHAKAEEICAKLSFHNTLRVRELTNVQLTTLSQLLSGMTIEGDLRRQRNADISRLVNIRCYRGMRHVNGLPVNGQNTRTNAKTAKKLNKVPRRGYMTLSPASTRPITWSFCLPRMVSVFQKLKHIH
Protein: SD01170p (Q961T2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSESLSSQVEETKVSDDDGVKEKAEVSTAKDSAETAMEVEADDTGGQQPEQSELLDKEKSATVDINTLTPSTPSQTPPQLLAVETATSGSTAVIPENILSPPKSETQTDETNTATSTSCSPASDGQRSPAANQQSSAPPPQVQAQATPAPVNGSVPKSGKPLSTALSGKKTSKAATTSPRASRCRKTKALPMYESEISDNKMGIRLCIKKSDAGEGAPAGVTSPPVAVPAATKTVRKRVRKPKQQDSDEAEYEPRKKKGGGGGSGGEKKVSTSPDAAEAAGDPVEQSVWAQKLPEEVLFRIFEHAVDTQGCLPTLFRLGRVCSLWRQVSLRPTLWRTMDLTTWVKEKYRTELKLKWFVDNRCSACTDLNVSNWKISDINCFLAKLSSGCPNLAGITLSGWKGFTSDHLTYLVDNMHKLQRLDLSSINVEMNASKSAVGVNSLCNALQTMGSRLTHLYLAHNRLAGIPQIVGILSTHCPNLTLLDLSNVTTQATSHGVLHIEKLQRGCQKLKVLRVTNSHITPSTASMQEIMDSPGFPELEELSVAALTDESRIISDDHLQRILKSSSKLKLLDVRNCTRLTHESLIRLPAWDIKHLFLSGCSVTRDMGSGLELIASKWAHSLIELDLAWANMQQPIDNALRALAEKGRDSPLAHLNLCGSSVSDEAVKEILTNCQNMSSINLASCRGLPRGVKRLMQGPQELGELREVLGVQLKSSSGSN