wanglab/gogpt-training-data huggingface dataset:
Protein: Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] (P52796)
Organism: Rattus norvegicus (Rat)
Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (By similarity). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3 (By similarity). Binds to, and induces the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
Subcellular location: Cell membrane {ECO:0000305|PubMed:7936648}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:P98172}. Note=May recruit GRIP1 and GRIP2 to membrane raft domains. {ECO:0000250|UniProtKB:P98172}.; SUBCELLULAR LOCATION: [Ephrin-B1 C-terminal fragment]: Cell membrane {ECO:0000250|UniProtKB:P98172}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Ephrin-B1 intracellular domain]: Nucleus {ECO:0000250|UniProtKB:P98172}. Note=Colocalizes with ZHX2 in the nucleus. {ECO:0000250|UniProtKB:P98172}.
Interaction partners:
- Ephrin type-B receptor 1
- Ephrin type-B receptor 6
- receptor protein-tyrosine kinase
- Ephrin type-B receptor 4
- receptor protein-tyrosine kinase
- Ephrin type-B receptor 3
- Cytoplasmic protein
- Regulator of G-protein signaling 3
- Ephrin type-A receptor 1
- Ephrin B2
Sequence:
MARPGQRWLSKWLVAMVVLTLCRLATPLAKNLEPVSWSSLNPKFLSGKGLVIYPKIGDKLDIICPRAEAGRPYEYYKLYLVRPEQAAACSTVLDPNVLVTCNKPQQEIRFTIKFQEFSPNYMGLEFKKYHDYYITSTSNGSLEGLENREGGVCRTRTMKIVMKVGQDPNAVTPEQLTTSRPSKESDNTVKTATQAPGRGSQGDSDGKHETVNQQEKSGPGAGGSGSGDTDSFFNSKVALFAAVGAGCVIFLLIIIFLTVLLLKLRKRHRKHTQQRAAALSLSTLASPKGDSGTAGTEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
Protein: Combgap, isoform I (B7YZE6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MCAAQNPPPFGYTWGFADNGNRAAESVLEISPNINYTVSGESMPYLLSTDGSLAVQKDVKGLTAGGKNNVVRRMFVVNDPSFPPGTQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAAAAAAAGGDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAAKSHFSSIGALHLTQEECNEILIKRAIAAGHHQTHTITAADGSHHHASGGTPSDILPGISVQVQKVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVCECGKAFFQKNHLMLHQRQHLETKPAISQQQVC
Protein: Nestin (Q9Z1Q1)
Organism: Mesocricetus auratus (Golden hamster)
Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).
Interaction partners:
- Vimentin
- Glial fibrillary acidic protein
Sequence:
WREKLEAEVQRQNLYQERVAHMESSLGQARERLGRAVRGAREGRLELQQLQAERDGLQERREALEQRLEGRWQDRLQATEKFQLAVEALEQEKQGLQSQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRSSQASLGFQDPKLKLRFLGTPENQHLGSVLPVLSPTPLPSPLPDTLETPVTAFLKTQEFLQARIPTLASTPIPPMTEAPCLAKAEVRAQDAPLSLLQTQGERQQAPEPLWAKATASVSTGVLTELEEAGGQQPGHFPEDATASAPSLSPHHPVLEAKDGDSTESRGSSIFQEDEGQIWELVEKEAAIELKVESSLAQETQEDGLHTEEIQDSQGPLQKETLEALGEEPLMSLKIQNHETPGKENCNSLRSVDENQGTLKSPEEEKQTLLKSLEEKDVEVEKTLEKGVPELSKPLGKEDPRIEDQELMSPEGTLETLSFIGKRNEEVVRSSEEENIESLAAFKKESQHPLGCPEEEIQRVERLIEKEGQESLSSPEEEDQETDRPLEKENGEPLKPVEEEDQLFETLIEKEGQESLSSPEEEDQETDRPLEKEEDQLVERLVEKEGQESLSSPEEEDQETDRPLEKENGEPLKPVEEEDQLFETLIEKEGQESLSSPEEEDQETDRPLEKEEDQLVERLVEKEGQESLSSPEEEDQETDRPLEKEEDQLVETLIEKQGQECLSSPEEEDQETDRPLEKEEDQRVERLIEKEGQESLSSPEEEDQETYRLLEKENGEPLKPVEEEDQRVERLIEKEDQESLSSLKEEDQRIVKTLERENWESLRSLDENLDTVMPLESKNQKPLKSLEAEEEQRIVKPLEKVSQDSIGSLEKENVELLRSLEDDQITESLLKKGTQESLESHEDRNQETQDPQRFLEEEGQGIVKQLEKENQGFLGSLEEEKVVKRSLERENHEPLSSVEKDWVTESLLERESQDSGKSLEGQEAFRCLGKEDPESLQFPEVQDQEIQRSLQQETQQTLGALGDEQMASEPPEKVGPELLKFLGNGQEIVRSLEEQNQESLVSVKETSVETAKSSDMEDIEPLKSADEDLEIINSAGAQESLWSMEVTRETTRPLEKEVQESLGFVGGNQEILRPLERGNEELGSLGKWNLEAVDSPEAVEEGRQPLGEEACLEMGEHQEPPRSLGEVEQGLPGSGNQQKWEDRAVENAAADQGPTLGRTGIESEDEAELPLSGQGEKEEDAEERELQLDAMGEAWSLASSEPQEPRVPSEGGSAGAPQGLEGQSEQVGVLGVPVGQGMPEVTEPLLQEDVAQAGKRDPIELTLGSDAATRAGLGLEQEVAGSGGSRHLAREEAIHPSLGEESVEAKIAHDLEGPGKEPKEAGALESEISELPRTSSDVLESKGCKQSEPVLGWAVEEASVEASDHEGSDAPEPRPSETEGDEGAQAALAPPGPKLMEPCSPTPILKDAYEWQPQAEGTRETGRQLEGGSASLERVEDEQEFGLGGIPEGLQDWEESREESEADELGETLPDSTPLGLYLRSPTSPKWDQAGEQRLSPQGEARKEGWGPAVPAAQGLSNPPGEEERGHDSDLSSEEFEDLGTEASLLPGLPKEVADHLGQVPPGPEPECWDQGGESDGFADEEESGEEGEEEEHEDGTESGAQWWGSGPSKVQHVTQRGDLQEHESVGISGPWDDGWRGAAAGISVTGLETESQDSAEPSGSEVSESVSSEGEDQAPDHLDTPQGVTNVVPGAGDTFGISGQAPNLESEHMNGRLENGLEQSEGQGVLDRHQDQGHPSQQQEVGALKAPLLGSPVHRGPSQSLEFPLSGADRDSWSSGED
Protein: GMNN protein (Geminin H) (Geminin, DNA replication inhibitor S homeolog) (O93352)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- CDT1 domain-containing protein.
- Origin recognition complex subunit 4
- Cell division control protein
- Uncharacterized protein.
- Origin recognition complex subunit 1
- DNA replication licensing factor MCM6
- DNA helicase
- DNA replication licensing factor MCM4
- DNA helicase
- DNA replication licensing factor MCM2
Sequence:
MNTNKKQRLDMEKPTMSIKNYFVDKTNESLAPRRTLKVIQPSASGCLVGRTKEPVKNSTKRKLWNDQLTSKKAKVEVAVDPEHRENKDCSSEAYDLMVKETPTCLYWKEVAEERRKALYEALQENEKLHKEIELKDEEIARLKQENDELMELAGHVQYMANMIERLTGNAPRSLEDLKDLDLEEARFEDEADMAEARIEDETDMARPSNSDQNMDAHTV
Protein: Candida glabrata strain CBS138 chromosome D complete sequence (Q6FWD6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome A complete sequence
- Candida glabrata strain CBS138 chromosome L complete sequence
- Candida glabrata strain CBS138 chromosome K complete sequence
- Candida glabrata strain CBS138 chromosome B complete sequence
- Transcription factor NRM1
- G1/S-specific cyclin
- G1/S-specific cyclin
Sequence:
MSNQIYSAKYSGVDVYEFIHPTGSIMKRKNDGWVNATHILKAANFAKAKRTRILEKEVLKEMHEKVQGGFGKYQGTWVPLNIAINLAEKFDVYQDLKPLFDFSEENGDAAPPPAPKHHHASKASSAKAKKAGRSVSSPAMNDSKTRASTRKANTPSSNDITSDSGAVVNPVVTRRRGRPPNSTLTNKRKLGTGLQRSQSEMAFLKPEIPNDLNSNDIANIQQVNSGDLLRNEKIQKNIQLKEIDLDDGLSSDVEVQETDTFQPNHQSSLLGAEGHELRNNDSPLSPSSSSSLPTSPANLNDSNPFDQRLGGGGTSPIISLIPRYSVQSRPQVTDINEKVNDYLTKLVDYFISNEMKSNKTVPQELLHPPTQSAPFIDAPIDPELHTAFHWACSMGNLPIVEALYETGTNIRAANANGQTPLMRSAMFHNSYTRRSFPRIFELLSETVFDIDSMGQTVLHHIVKRKSSTPSAIYYVNVLLSKIKDISPKYRIELLLNTKDANGDTALHIAARNNDREFFDILIKNGSLSTISNNDGQTPTEIMNQHYQDLHLQAQTNIAGSNTSAYTDSFSSFGGKVKGSKLHSISELDDDKNTQNPENTVTNIVSNLHFSSNAAINLVKNIPAFTDSMKHLAEKFDGSYKNHEESCRSTEKMLGSIKRTVHSTDNRIREILETDADADISSAILAQEKDITELKIEAENHLRKLKNQFEYLQKQRLLKLTEYHNGEHNDTDNTLDNKIEICKQISVLQIERKRKISELISHYEDSRKIHKYRRMISEGTEMKTEEVDGCLDIILQTLINNSS
Protein: Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C) (O60635)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000269|PubMed:21836059, ECO:0000269|PubMed:30291375}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:19508227}; Multi-pass membrane protein {ECO:0000269|PubMed:19508227}.
Interaction partners:
- Transmembrane 4 L6 family member 5
- Transmembrane 4 L6 family member 1
- Thiamine transporter 1
Sequence:
MQCFSFIKTMMILFNLLIFLCGAALLAVGIWVSIDGASFLKIFGPLSSSAMQFVNVGYFLIAAGVVVFALGFLGCYGAKTESKCALVTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSAFPPFCCNDNVTNTANETCTKQKAHDQKVEGCFNQLLYDIRTNAVTVGGVAAGIGGLELAAMIVSMYLYCNLQ
Protein: Fondue, isoform B (Fondue, isoform C) (HL01053p) (Q9VIX7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Nuclear pore complex protein Nup133
- Nuclear pore complex protein Nup107
- Nuclear pore complex protein Nup75
- Nuclear pore complex protein Nup154
- Protein SEC13 homolog
- Nucleoporin seh1
- Probable nucleoporin Nup54
- Nucleoporin 43kD
- Nuclear pore complex protein Nup214
- Nuclear pore complex protein Nup160 homolog
Sequence:
MNKLLILALCLGVVCGDFQQSLGRTKRDSFHSRHYSTHGQAVEQARKNAGYGGGYSGSFGAGVDGASAQVDDSALGKLESSYDSVGATESAEGASAGGLGGAVETLGGSAGTNTIGAGVGSSFGSNFASGFGGQNAASFGAQNAAGFGAQNAASFGAQNAASFGSSFSSNAAFQTSSASNFGSTAAHQVGSNVEFADNANAGNKVDFGGVNAVDSSAQLLSGVQTVQSVPTSEYYRHEKIVSTPQQVVYTIPGGSQRYVHHEERIVEQPTQVTQTVPVQTAHYYQRKVTTTASAPQLVQPVASSRLTYGSNAASTFGSNAASNFGSNAATNFGSNAATNFGSNAAFNSQFGSSYGQNFQQNSQLSQLLSQTQQAARQQAALQAASANQVQAGSGYAAGSQGGFNSGYNSAFNSGSQFGFNSASSLNSASSLNSASTGNSAALLSGSLLGGSQGSLLSGQVGGQQSLLSGSLLSGQQNLGLGLNAAQTGQVVGASSVGAGLSAGAGNLGSGYRTKQWEKQSKWSSQNSYDSNGHVNNYKDLVTGESESVDINGKRAGYHAVTASVDDNGKIGTHSVHS
Protein: DNA replication licensing factor mcm-4 (EC 3.6.4.12) (Q95XQ8)
Organism: Caenorhabditis elegans
Function: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Required for DNA replication as well as for the subsequent DNA replication checkpoint controlling entry into M phase in embryos and in postembryonic somatic blast cells. Required for normal growth and viability, specifically via tissue-specific expression in the hypodermis.
Subcellular location: Nucleus {ECO:0000269|PubMed:21146520}. Chromosome {ECO:0000269|PubMed:21146520}. Note=Colocalizes with chromatin in late anaphase but not in prophase or metaphase. {ECO:0000269|PubMed:21146520}.
Interaction partners:
- CDT1 Geminin-binding domain-containing protein
- DNA replication licensing factor MCM2
- DNA replication licensing factor mcm-6
- DNA replication licensing factor MCM3
- Cell division control protein
- DNA replication licensing factor MCM7
- DNA replication licensing factor mcm-5
- DNA replication complex GINS protein SLD5
- Protein MCM10 homolog
- Minichromosome loss protein Mcl1 middle region domain-containing protein
Sequence:
MPRSNDPAEPQSESADLFAEPSSQHSSMRSGSEQVAGNMSPRSTSSASALQYGSEMGSVSQMSSASTLRRGGPRGDLGIAAVDHRTVQIRGMEDEMAGDDGQPRLYVWGTRICVADVQRSFRDFLTTFKISQLAEDENMMTGHDEALHEIDVNHPYYMERLLECNDAEVTHINLNLKHLNAFSEALYRKVIAYPADVIPYLDIVVNEVFAERFNRTLAQSIELRPFNAQKTRNMRGLNPNDVDQLITISGMVTRTSSLIPEMRSGYFQCAVCAFGIESEVDKGRIEEPVVCTNCSNTHCFQLVHNRSVFLDKQVVKLQESPDDMPSGETPHTVSVYAHGSLVESVQPGDRITVTGIFRATGMKVNPKQRALASVYRTSIDALHFRKMDTSRLHQDNGETITEERIQQIIELSKRPDIMDALAQSIAPSIYEHDDVKRGLLCLLFGGTRKDDETTNKTKLRSEINILLCGDPGTSKSQMLQYVYRLLPRSQYTSGKGSSAVGLTASVSRDADTKQLVLQTGALVLADNGVCCIDEFDKMNESARSVLHEVMEQQTLSIAKAGIICQLNARASVLAAANPVDSKWNRNKTIVENITLPHTLLSRFDLIFLIVDAQDEMQDRRLGNHLVSLYFENDGNQEKTEHVDMNLLRDYIAYAKANIHPKLSEEASQFIIEKYLFMRKAGAQHGQITAYPRQLESLIRLSEAHAKIRLSQEVSVDDVEKAFTLWREALKQSAVDPSTGRVDVAILASGMSASGRKAVEAMCEAVLKQLKTAKGFVTSKALFHTLKSADKTCQREVFDEAINELSKKESIARSGDRIRFQTEA
Protein: Glycoprotein gp100 (P29F8) (Q06885)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Golvesin
Sequence:
MKNFILLVFLFLLVSNSLGKSNKKDDQSPEIVKINSNDHLPLYYEIIISGHFSIDKTGLTVTYLGDKIHDFEFIKGQVLNVTGEPQNNPIPTVSINPDQLNDDRFEVSDSSDFSKQTPTPTPTPTSKPTSTPTSTPSQTIPPTVSPTVPPQTTSPTSKPTSTPTPTSTPTPTSTPTPTSQTIPPPTTTPKPTKSSKPTKTPVPTPTPTRPSSSVSKGYDIIKFNITDIEDIEMGKITISYKNGQSSSKHFQPNSIIKSIERTNSVGGVVEFKGSFFYTDDYEPSIKIGNKICETLTSSQTSIRCYLTNGTGCGYTITIDNLLNPIDNNGNSNLTYCYANPIIDKVIGYKDKKLTLITIIGKNFLNNATVIIEKPNGNKRNCSNVLLSTDTLFICELSKSYHTLSSPKTTNTTMLSFINNSPNSTVSNEIIEMISGYFQIKISTKPSTTDDDNNKNNDDGDSEIDSVGKSAVDSSKSNNNSGGGGNKKLYLLIILPTVLFIIVAALVAIFIKTRVSQNSGSKVNKNNNKKDSINVPFQMLDEITT
Protein: SAFB like transcription modulator (H7BXE3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKK
Protein: Caspase 8 associated protein 2 (D4A7V6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Caspase-8
- Programmed cell death protein 10
Sequence:
MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSTVSDSTARSCVSFRNCLDLYEEILTEEGTAKEATYSDLQIEYGKCQQQMKDLMKRFKEIQTQNLNLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSRSKSPHLDNCSKTDHGVKSDVQKDIHPNTSQPNLEKEGKSHSEAQNSLHLSTGIEKHCTNNVWSRSPYQVSEGNSNEDNRRGRNGVRHSQGSRGTDRTQKDLNSSCNDGEPRDKEAASRLHGNPEKHGSSEARAENKISEIKSSTGLGNKSERSASSWEKETSRERPHTRVEPQNDKNLERQNERLQNTHRKELQSQDKAERKGDVKFKPAGEEQGHRGRVDRALPPHSKNDMKYYGFNKYHPEERRGREDGKRDRGMSSHGFQDRRCSSSLSSNRNSKYPHSKEVSVAHQWENTPFKAERHRTEDRRKRERENKEESRHVKSDKKSPPEHLQRTHKDTKKSTANGKRQTEQKHGKGPVSTSELSKGTDNRECTMKVENGPNEAKGKDLKLSFMEKLNLTLSPAKKQPVCQDNEHQIIGVPKPSGVCDSQSLEKTETVACLPSVSEQDREEPKSELPEPKEALSATSQPRTSIPENKVKEENRLLFKSVENTVPCELLACGTEISFPAPVEIEQARCLVQSMEVEETCAGARAAASVVMRVLPEHASEDFSQELGTKRHDDINSCDISEGGKKKVVLSPKAAAASESHLEPVVEEPSISPVNCSGDNNPKLEPSLEERPKVENKSSPLEPCLPKEMFVPSPQKTELIDHKIDTGESNSVYQDDDNSVLSIDFNNLRPIPEPISPLNSPVRPVSKVLSMESSCTIPLYDSSHKDEFPSNSTLSTFKSQSDLNKENEKPVPKLDKCSEAESCKNLSVDELEEGEIRSDDEESVAQKRLEKSARPRTSTEVPPGKISPGSRRSTVHVHKDNGRTVVKLPRDRITWSQRSNESRPSNTERKSKTMSISSLEKILPLILAPSSVWEVMHMLRLLGKHVRKNYMKFKIKFSLTQFHRIIESAILSFTSLIRYLDLSKICKSVSTLQKSLCDVIESNLKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQLDYLFEKLKKILLKFCDSVKHENDSSEGKLGKKYKERAQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKFEEKHQDQNKTNTTTVKHDVKRTFSTCTDNNTKNSECKEQFLGMNCPSTPRPGETEGNVEEGTPAAQHACVKSERGFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDTGGTEKAEWELKTPEKQLLESLKCESAPACTTEELVSEAASLCPKVISDDNWSLLSSEKGPSLSSGLSLPVHPDVLDENCMFEVSSNLALSKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGHLSFLKPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTSRSVASGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSPGLKHGMVAEESLTPLPRTGKEADGAAEKEPTLFQSTVLNPVQDLENSDKSIDKSKPTHEDQNSIVQTQVPDIYEFLKDASNKVVHCDQVVDDCFKLHQVWEPKVSESLQELPSMEKNAHSVDDHLPNTHIDLTKDPATETKSLELMDVTVLDIDHLEHSKPNLDQDAQITCTSLQHDAVDAFIDLTHDVSNESKNESNEPVLTVEGVGCQVICIDDDNHKEGKVGKVNSSLECTVEETCIDLTSESAGSFEVKRHTLKSEPPSKSDCLELPETLGNGHKKRKNSPAVSHSSQKKQRKDMDLSSEKTKRLSPNSDRTGDAHRKHGSKKREPAVSDTSLSSEVNPEVKGSTAPLATFPGSLSAKNVIKKKGEIIVSWTRNDDREILLECQKRMPSLKTFTHLAVKLNKNPNQVSERFQQLKKLFEKSKCR
Protein: Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) (Q9HB90)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11073942}. Nucleus {ECO:0000269|PubMed:11073942}. Lysosome membrane {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:28935770}. Note=Predominantly cytoplasmic (PubMed:11073942). Recruited to the lysosome surface by the Ragulator complex (PubMed:20381137, PubMed:28935770). May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). {ECO:0000269|PubMed:11073942, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:28935770}.
Interaction partners:
- Serine/threonine-protein kinase mTOR
- Ras-related GTP-binding protein B
- GATOR2 complex protein WDR24
- Ragulator complex protein LAMTOR2
- Ras-related GTP-binding protein A
- Regulatory-associated protein of mTOR
- GATOR1 complex protein NPRL3
- Ragulator complex protein LAMTOR4
- Neutral amino acid transporter 9
- Ragulator complex protein LAMTOR5
Sequence:
MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI
Protein: Ankyrin 2 (A0A5F9ZHN0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKSGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Protein: Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)] (P20382)
Organism: Homo sapiens (Human)
Function: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.
Subcellular location: Secreted.
Interaction partners:
- Melanin-concentrating hormone receptor 2
- Melanin-concentrating hormone receptor 1
- Hypocretin neuropeptide precursor
- Pro-neuropeptide Y
- Pro-opiomelanocortin
- PCNA-interacting partner
- Proenkephalin-B
- Agouti-related protein
- Galanin peptides
- Oxytocin-neurophysin 1
Sequence:
MAKMNLSSYILILTFSLFSQGILLSASKSIRNLDDDMVFNTFRLGKGFQKEDTAEKSVIAPSLEQYKNDESSFMNEEENKVSKNTGSKHNFLNHGLPLNLAIKPYLALKGSVAFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV
Protein: Protein SINE1 (Q5XVI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in nucleus positioning in guard cells.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:24891605}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- SUN domain-containing protein 2
- SUN domain-containing protein 1
- Protein SINE3
- TIR domain-containing protein
- Protein SINE4
- SUN domain-containing protein 3
- Hypthetical protein
- WPP domain-interacting tail-anchored protein 2
- WPP domain-interacting tail-anchored protein 1
- Nuclear envelope-associated protein 1
Sequence:
MGLNLNPILRQELANLDKDTESRKSAMKALKSYVKDLDSKAIPGFLAQVFETKETNSLSGEYTISLYEILARVHGPNIVPQIDTIMSTIVKTLASSAGSFPLQQACSKVIPAIARYGIDPTTTEDKKRVIIHSLCKPLTDSLLASQESLTSGAALCLKALVDSDNWRFASDEMVNRVCQNVVVALDSNSNQTHLQMGLVMSLAKHNPLIVEAYARLLIHTGLRILGFGVSEGNSQKRLSAVQMLNFLMKCLDPRSIYSEVELIIKEMERCQSDQMAYVRGAAYEAMMTSKRIAAELESKMEKGCRSVTGSNFSRRNCSSIVPDYSLSPESQTLGSFSGYDSPVESSPISHTSCNSEFDRRSVNRKLWRRDENGGVVDISLKDGLFSRVTKGSTTVSDSPLVPYDTCENGDEFEGFLMESLRNTTPSPQRQRSRRINAEDFNIFSTPRKLISSLQYPDDVDLDHSDIQSPILRGEREKTIGSRKNPKLRKQFPTMVETMSSTITVSEDTAQTQMITGKKKKKKMSYAKLVIAISFVVVALFATVILMVNQDDDVGYYTVPT
Protein: Protein IQ-DOMAIN 20 (AtIQD20) (Q9SD11)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:28115582}. Cell membrane {ECO:0000269|PubMed:28115582}. Note=Recruits calmodulin (CaM2) at plasma membrane subdomains. {ECO:0000269|PubMed:28115582}.
Interaction partners:
- Protein IQ-DOMAIN 9
- Protein IQ-DOMAIN 33
- Protein KINESIN LIGHT CHAIN-RELATED 1
- Protein IQ-DOMAIN 10
- GPI-anchored adhesin-like protein, putative
Sequence:
MANSKRLFGVVRRKLLRRSQSRITIIRSSAPETTREEIAAVKIQAFFRGHLARRAFKALKSLVKLQAVARGVLVRRQARIALHCMHALARLQVRVRARQLLSH
Protein: Probable inactive receptor kinase At5g16590 (Q9FMD7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Might be involved in early recognition of growth promoting fungi. Appears to be specific for P.indica.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16146321, ECO:0000269|PubMed:17397506}; Single-pass membrane protein {ECO:0000269|PubMed:16146321, ECO:0000269|PubMed:17397506}.
Interaction partners:
- Subtilisin-like protease SBT4.9
- Subtilisin-like protease SBT4.4
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Protein IQ-DOMAIN 3
- Putative defensin-like protein 3
- At5g06330
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- IQ-domain 21
- Aquaporin PIP2-7
- Probable protein phosphatase 2C 64
Sequence:
MKNKTNLGLSVFFFFICLVSVTSDLEADRRALIALRDGVHGRPLLWNLTAPPCTWGGVQCESGRVTALRLPGVGLSGPLPIAIGNLTKLETLSFRFNALNGPLPPDFANLTLLRYLYLQGNAFSGEIPSFLFTLPNIIRINLAQNNFLGRIPDNVNSATRLATLYLQDNQLTGPIPEIKIKLQQFNVSSNQLNGSIPDPLSGMPKTAFLGNLLCGKPLDACPVNGTGNGTVTPGGKGKSDKLSAGAIVGIVIGCFVLLLVLFLIVFCLCRKKKKEQVVQSRSIEAAPVPTSSAAVAKESNGPPAVVANGASENGVSKNPAAVSKDLTFFVKSFGEFDLDGLLKASAEVLGKGTFGSSYKASFDHGLVVAVKRLRDVVVPEKEFREKLQVLGSISHANLVTLIAYYFSRDEKLVVFEYMSRGSLSALLHGNKGSGRSPLNWETRANIALGAARAISYLHSRDATTSHGNIKSSNILLSESFEAKVSDYCLAPMISPTSTPNRIDGYRAPEVTDARKISQKADVYSFGVLILELLTGKSPTHQQLHEEGVDLPRWVSSITEQQSPSDVFDPELTRYQSDSNENMIRLLNIGISCTTQYPDSRPTMPEVTRLIEEVSRSPASPGPLSD