Protein: Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Q20060)
Organism: Caenorhabditis elegans
Function: Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Also a central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation. Both the condensin complex I and II play a role in meiotic and mitotic chromosome segregation. Plays a role in robust cytokinesis upon the presence of chromatin obstructions.
Subcellular location: Nucleus {ECO:0000269|PubMed:11914278}. Chromosome {ECO:0000269|PubMed:11914278}. Note=Localizes to condensed chromosomes during mitosis and meiosis. Localizes to chromosomes in a faint speckled pattern during prophase, then appears in two stripes outlining each chromosome during prometaphase. During metaphase, localizes at the poleward face of the condensed chromosomes. Dissociation from chromosomes is observed in late telophase. {ECO:0000269|PubMed:11914278}.
Interaction partners:
- Condensin complex subunit 1
- Mitotic chromosome and X-chromosome-associated protein mix-1
- Condensin complex subunit capg-1
- CAP-G condensin subunit
- Condensin-2 complex subunit hcp-6
- Condensin-2 complex subunit kle-2
- Condensin complex subunit dpy-26
- Uncharacterized protein C30G12.6
- Structural maintenance of chromosomes protein 5
- Structural maintenance of chromosomes protein 6 homolog smc-6
Sequence:
MPPKTSAAPPQSDESDSDFDDAPVKKPQKKTTKPVNRHKEGSKDPEEELQRAVNEKFDGSDGEDDDSDLFSLQLPSRPDFLTKPNRADRLMIRNVEVDNFKSYFGKASIGPFHKSFTSIIGPNGSGKSNLIDSLLFVFGFRASKIRSAKVSNLIHKSAGRNPDKCTVTIHFQRIVDIPGHYEVVKDSEFTISRTAFQNNSSSYAIDGRPATKNEVEARLRRVDIDIEHNRFLILQGEVEQIAMMKPVKTTKSETGMVEYLEDIIGTNRLEPFVKLFQRRVNRLTCDLSQQRIARDHARNSKVAMENPVRAAIEFLMKENEATTIHMKLEQRRRQRYLDKIAPKQAELDKMKEEMKSIAETLDTNKNEYKQSEEAQKVMIEERSKLDKNFDSLSKELSDLGTEETRRKEALKRHQANISKAEAEKEKEVKKRSNLEAAPEKAERKIAKCQEEVEQLLEIEKTANEEADKNLDEFEKRSEAPKEEQKKIQETWAQKSNEFNKVRGEARIAREDFEDLKKLANSGTDKLIELKKRLESSEESYAKEKDELDKLKPEFDSWNDKLKQLSTELPTLRNTARQKNQDLAKTRDRLETLRQQNSSCSSSNKVIQALMKEKEAGRIKSFHGRLGDLGVIDPKYEGAICTNFGARLNYLIVGKEEDAKNVINFLVANKLPRQTVQPLDKIKCDKRDLAPNPTNPLPAPRLIDLIDCDPVLKPAFYDMVRSAIVGDSTQEAQRMHRMPACRGVTVCTLEGSMIHPSGSFTGGGKTVKGLILTDKNKMAKQVTPEDKAAERDLAEKLGKLRDEADELKGQEHEMDGQLIEARRKVAEMSNRLSIVTSSVQSAAPAIETLKKTIANQEKEAAKVKVDAKTLEDKQKIVEELEKKRDELGEEAAKVKARQAEIQSKLDGIFKELVQCHRDEAKESLQKRQKLEKDIAKETANISNSGRNIAKCDENISRHDKDIEKMKKKCEELMEKAIDDEEVKSKKETVERFEKQIKKLQTKGEEMTKKQSELSAAETKLEGELKKCSEGIKELKESMLADRLKVEDIEKKLAALKVNRIPRFQFLIESSRPEDLEMQIDDKMPVVDENQSPEEVERQKKHMACVMSDAAYALEFEMRQKVLENTESYENVDGEDRVPVELLSDEKINEISSRDAEEMQMKLKVCEQQVEALKAKVDISSIKAYVDKVKQYNEQVIKLTIATEVHRKHNQELQRIKQMRLEEFHSAFEFIGKHLVAVFKMLTDGGDAKLEYIDKDDPFRQGISFMVRPAKKAWKQIQFLSGGEKTLSSLALIFALHMFRPTPFYVMDEIDAALDYRNVSIIAQYVRQKTENAQFIIISLRNNMFELANRLVGIYKVDGCTRNVAIDPLRVCEMAKQITDSLGQATCTLPDEVTQRFNETMSRQNKEMIAQEKQYPNFPSSNEISKAEKIVNVEGRVRKELIQTTRDVTSRPQSKATTSGDGTERPASRSASRPESRINQMKYPAPRLVERSSSQNVRSPRKARNIEADETTPPSKRSNSASTPKRSPMKPLTPSSKKKEKAIVDDDDDME