Protein: Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (Protein kohtalo) (Protein motionless) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Q2QCI8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for development of the body axis, brain, ear, kidney, forelimb and neural crest and for pigmentation. Acts as a coactivator for sox9a and/or sox9b promoting the expression of several neuronal determination genes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 13
- Cyclin C
- Cyclin-dependent kinase 8
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 14
- Cyclin-dependent kinase 19
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 6
Sequence:
MAAFGVLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNSSKISSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITENKMKKRHVIDPCIEWTPIITKYLWEQLQKVAEFYRQSPSQGCGSPLPAPPAEVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSIGPGPGGHQAHGISAQQGNALPPTPTSQPAGGNQPQTPFTDFYICPQHRPVVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSNLPMPGGNSTFNQQVRAKVREIEEQIKERGQAVEFRWSFDKCQETTAGFTISRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVSCKRSGPHRAMVVAKLLEKRQTEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPVLTEPGNESERVEFSNLVLLFYELIRHDVFSHNIYMCTLISRGDLASNSHLPRPRSPSDEPSDESERKDQDAGSSVKMEDTGMSESMEIDHNSSANFDEMFSPPMHCESKGSPSPEKQAQEQESKSTAKDKGMDPAFPLVYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSNLAGSYTTGLCLCIVAVLRRYHSCLILNPDQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSEFCSKVKNSIYYNIDPSDSNMLWDQMFMIDAITNPTAHNLNHSMLGKITNELNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFRTPQRNPCPQDGTKSDKSIVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAGLDDIGEDDMGSKKSGGRNVSIETASLVVYAKYVLKSICHQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSSNNELYSLLENIAKATIEVFQKSAEMNSSNPSWNGSAVSGSSVSNSNSASKLKPVLSSSERSGVWLVAPLIGKLPTSVQGHVLKAAGEELEKGQHLGPSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTIRVDRKVTKFEEQQRLLLYHTHIKPKQRSYYLAPLNLPQEEEEPLTPVPPEPDKKLDTAKVEKSVSNVPTKKKKKKPASTVKQEDYKPHNTVMQYAPGMTPDLPLSMGQTNMSYRMGYQAPMNMYAQNQPLPPGGPGLEPPFRPRVPMNKMPPRPNYTMPNMQTAGMGNLMGMEKQYQMNYKPMPNMAQGQMLRHQLQGHNHLIGQQIRQVTPNPQYSSMQPAQNIPQGYTSYGSHMGMQPHPSQTPGMVPNSYGNQGFQTGHPATNPTMVDSIRQMQQRPGYVHQQAPAAYGHTIQSTQRFPHQSMQQTPMMHGLAQSHLGVQGIHPNMRPNQMMEQQQQQQQQQQQQQQQQQQVHQQQQHIRQGPVFRPQQQQQVQQQVQQQVQQQQVQQQQVQQQVQPQQVQQQQVQQQQQQQVSAAQPPAQALGMQALPPQQPMFQRQGMQQTQQQQQTAALVRQLQQQLSSTQPAQNNSSYY