wanglab/gogpt-training-data huggingface dataset:
Protein: Actin-related protein 2/3 complex subunit 3 (Actin-related protein C3) (Arp2/3 complex 21 kDa subunit) (p21-ARC) (Q1ECJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 5B
- Actin-related protein 2/3 complex subunit 1A
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 2B
- Actin-related protein 2/3 complex subunit 2A
- Actin-related protein 2/3 complex subunit 5A
- Actin-related protein 3
- At4g14145
Sequence:
MVYHSSFVDEEGVTKACGCPLLPLKSHIKGPAPVSEQDKTDIVDEAITFFRANVFFTNFDIKSPADKLLIYLTFYINVALKRLEGCRTLAVGTKAIINLGLEDIPVPGETGFPFPGLFSLPQSQDEAELFRNYLKQVREETSGRLLSVAYRANGTPNKWWLAFAKRKFMNVVVL
Protein: Devancosaminyl-vancomycin vancosaminetransferase (EC 2.4.1.322) (Devancosamine-vancomycin TDP-vancosaminyltransferase) (Glycosyltransferase GtfD) (Q9AFC7)
Organism: Amycolatopsis orientalis (Nocardia orientalis)
Function: Catalyzes the attachment of L-vancosamine to a monoglucosylated heptapeptide intermediate during the final stage of glycopeptide antibiotic vancomycin biosynthesis.
Interaction partners:
Sequence:
MRVLLSVCGTRGDVEIGVALADRLKALGVQTRMCAPPAAEERLAEVGVPHVPVGLPQHMMLQEGMPPPPPEEEQRLAAMTVEMQFDAVPGAAEGCAAVVAVGDLAAATGVRSVAEKLGLPFFYSVPSPVYLASPHLPPAYDEPTTPGVTDIRVLWEERAARFADRYGPTLNRRRAEIGLPPVEDVFGYGHGERPCWPADPVLAPLQPDVDAVQTGAWLLSDERPLPPELEAFLAAGSPPVHIGFGSSSGRGIADAAKVAVEAIRAQGRRVILSRGWTELVLPDDRDDCFAIDEVNFQALFRRVAAVIHHGSAGTEHVATRAGVPQLVIPRNTDQPYFAGRVAALGIGVAHDGPTPTFESLSAALTTVLAPETRARAEAVAGMVLTDGAAAAADLVLAAVGREKPAVPA
Protein: AP complex subunit beta (A5PMS9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00029433}.
Interaction partners:
- Intersectin 2a.
- Intersectin-2b
- AP-1 complex subunit gamma.
- AP complex subunit sigma
- Adaptor-related protein complex 1 subunit mu 2
- AP-1 complex subunit mu-1
- AP-1 complex subunit gamma
- AP-2 complex subunit alpha
- AP-2 complex subunit mu-B
- AP complex subunit sigma
Sequence:
MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPNSNLLDLNPQTINKLLTALNECTEWGQIFILDCLANYTPRDDRESQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLPKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICHIGTLASVYHKPPSAFVEGSRGVQHKRLPARAGSGESAESPEVGQSGTSEAPPAVIPSQGDLLGDLLNLDLAPATTTVPSVQPSMQMGAMDLLGGGLDSLLGGDIGGSPSMGAALGAPAAMPAALSNAPAVGGGLGDLFDLGGGVGMPTGFYVAPKTLFLPAMKAKGLEISGTFARRGGIIQMDLSLTNKAMSVMTDFAIQFNRNSFGLAPAGPLQVLTPLTPNQTIDVSLPLGTTGPVMKMEPLNNLQVAVKNNIDVFYFSCQYPLSLLFVEDGKMERQVFLATWKDIPNDNEAQFQIKDVHLNSDAASNKLQGSNIFTIAKRTVDAQDMLYQSIKLTNGIWVLAEMRVQTGNPNYTLSIKCRAPEVSQFVYQCYELVLKN
Protein: GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) (P22288)
Organism: Rattus norvegicus (Rat)
Function: May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P30793}. Nucleus {ECO:0000250|UniProtKB:P30793}.
Interaction partners:
- GTP cyclohydrolase 1 feedback regulatory protein
- 6-pyruvoyl tetrahydrobiopterin synthase
- Inosine triphosphate pyrophosphatase
- Vesicle trafficking 1
- Molybdenum cofactor biosynthesis protein 1
- Intestinal-type alkaline phosphatase 1
- Alkaline phosphatase
- Alkaline phosphatase, tissue-nonspecific isozyme
- Intestinal-type alkaline phosphatase 2
- Nucleotide triphosphate diphosphatase NUDT15
Sequence:
MEKPRGVRCTNGFPERELPRPGASRPAEKSRPPEAKGAQPADAWKAGRPRSEEDNELNLPNLAAAYSSILRSLGEDPQRQGLLKTPWRAATAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS
Protein: Homeobox protein Hox-B8a (Hox-B8) (Q8AWZ0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MSSYFVNSLFTKYKSGDTLRPNYYECGFAQDLGTRPTVVYGPGTGATFQHAPQIQEFYHHGASTLSAAPYQQSPCAVTCHGEPGNFYGYDALQRQTLFGAQDADLVQYSDCKLATGGIGDETDNTEQSPSPTQLFPWMRPQAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKSEQEQIEKEKREKEQASGTQSAGEDCDKAKQM
Protein: Myosin-IB light chain (MyoB light chain) (Myosin light chain mlcB) (MlcB) (Q54GL7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Functions as the light chain for myosin-B. Binds calcium with submicromolar affinity and may sense physiological calcium changes.
Interaction partners:
- Myosin IB heavy chain
- Myosin ID heavy chain
- Probable serine/threonine-protein kinase roco11
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase qkgA
- Probable serine/threonine-protein kinase roco5
- Inositol 1,4,5-trisphosphate receptor-like protein A
- Ras GTPase-activating-like protein gapA
Sequence:
MSDEKTQLIEAFYNFDGDYDGFVSVEEFRGIIRDGLPMTEAEITEFFEAADPNNTGFIDYKAFAAMLYSVDES
Protein: Low-density lipoprotein receptor-related protein (Q9NHE9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MALEPYTKSAEIEPQLCQVIDNNEDVTTKATKCTKSNSGVGWRQMLIGFLLICFGISNSWQYKNVHMPSSSSLIASPPASAFVNTPATLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIVNNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKELIDTPKAPNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLISANTCANGSQEMMFIVQRTQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVXDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTESPTDSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSGKNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELAYKLEGVTALALDQQSDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERITVNGERRSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLLEDKENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRADQFSCQSGECIDKSLVCDGTTNCANGHDEADCCKRPGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAPATDKRAFMILIGATMITIFSIVYLLQFCRTRIGKSRTEPKDDQATDPLSPSTLSKSQRVSKIASVADAVRMSTLNSRNSMNSYDRNHITGASSSTTNGSSMVAYPINPPPSPATRSRRPYRHYKIINQPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQYGYDSEPYPPPPTPRSHYHSDVRIVPESSCPPSPSSRSSTYFSPLPPPPSPVQSPSRGFT
Protein: Peroxisomal multifunctional enzyme A (MFE-A) (MFE-1) [Includes: 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)] (Q9NKW1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Protects the cells from the increase of the harmful xenobiotic fatty acids incorporated from their diets and optimizes cellular lipid composition for proper development.
Subcellular location: Peroxisome {ECO:0000269|PubMed:12796309}.
Interaction partners:
- Probable enoyl-CoA hydratase 2
- acetyl-CoA C-acyltransferase
- Peroxisomal acyl-coenzyme A oxidase 1
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Probable enoyl-CoA hydratase, mitochondrial
- Probable enoyl-CoA hydratase, mitochondrial
- malate synthase
- isocitrate lyase
Sequence:
MALNFKDKVVIVTGAGGGIGKVYALEFAKRGAKVVVNDLGGSHTGQGSSSKAADKVVEEIKAAGGTAVANYDSVEDGEKIVQTAMDSFGGVDILINNAGILRDVSFGKMTDGDWDLVYRVHAKGAYKLSRAAWNHMREKNFGRIIMTSSAAGLYGNFGQANYGSMKMALVGLSNTLAQEGKSKNIHCNTIAPIAASRLTESVMPPEILEQMKPDYIVPLVLYLCHQDTTETGGVFEVGAGWVSKVRLQRSAGVYMKDLTPEKIKDNWAQIESFDNPSYPTSASESVSGILAAVNSKPADGESVLVRPPKVAVPKALAATPSGSVVVDGYNASKIFTTIQGNIGAKGAELVKKINGIYLINIKKGTNTQAWALDLKNGSGSIVVGAGSTKPNVTITVSDEDFVDIMTGKLNAQSAFTKGKLKISGNMGLATKLGALMQGSKL
Protein: Homeobox protein ceh-63 (A3FPJ2)
Organism: Caenorhabditis elegans
Function: Probable transcription factor, modulating expression of helix-loop-helix protein mbr-1, perhaps acting in concert with homeobox protein ceh-14. May play a minor role in axon guidance in the DVC interneuron.
Subcellular location: Nucleus {ECO:0000255|RuleBase:RU000682, ECO:0000269|PubMed:22207033}.
Interaction partners:
- Paired domain-containing protein
Sequence:
MTSKTNMTSNKFAYDFFPWSNDTNSSQQIKNIKPPPKRSNRPTKRTTFTSEQVTLLELEFAKNEYICKDRRGELAQTIELTECQVKTWFQNRRTKKRRCTSPLRKSMMKKSDERSPSPQNPSSQHVQNLQTFFHSWPSHFAYSLPSDQQNNV
Protein: Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin-5 subunit beta) (Nicein subunit beta) (Q61087)
Organism: Mus musculus (Mouse)
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.
Interaction partners:
- Laminin subunit gamma-2
- Laminin subunit alpha-3
- Laminin subunit alpha-1
- Laminin subunit beta-1
- Laminin subunit gamma-1
- Integrin beta-4
- CD44 antigen
- Laminin subunit alpha-5
- Laminin subunit beta-2
- Peripheral myelin protein 22
Sequence:
MTAFFLLWLALPGFLCAQQACSRGACYPPVGDLLIGRTQLLRASSTCGLTKPETYCTQYGQWQMKCCKCDSRLPRNYNSHRVENVASSSGPMRWWQSQNDVSPVSLQLDLDKRMQLQDIMMDFKGLTPAGMLIERSSDFGKTWRVYQYLATDCASTFPQVHQGQPKNWQDVRCRPLSQRPNGHLTGGKVQLNLMDLASAIPASQSKKIQELGDITNLRVNFTKLAPVPQRGSYPPSAYFAVSQLRLQGSCFCHGHADRCAPNPGGSTTAVQVNNVCVCQHNTAGPNCDRCAPFYNNRPWRPAEGQDTHECQRCDCNGHSETCHFDPAVFAASQGTNGGVCDNCRDHTEGKNCERCQLHYFRNRRPSAPIHETCIPCECDPDGAVQGAPCDRLTGQCVCKEYVQGERCDLCKPGFTGLTFANPKGCHACDCSILGARKDMPCEEETGRCLCLPNVVGPKCDQCAPSHWKLASGLGCEPCACDPRNSLSSQCNQFTGQCPCREGFGGLTCSSAAIRQCPDQTYGHVATGCRACDCDFRGTEGPGCDKASGRCLCRPGFTGPRCDQCQRGHCDRYPVCVACHSCFQAYDTDLQEQARRLHSLRNATEGLWTGTGLEDHGLASRLLDAKSKIEQIRQILEGTSVTEQDVAQVANGILSIRRTLQGLPLDLPLEEEMESFSGDLGNLDRSFSRLLLMYRSKKEQFEKLSSEDPSGAFRMLTMAYEQSSRAAQQVSDSSSLLSQLRDSRREAEGLERQAGGGGTGGAQLMALRLEMASLPDLTPTINKLCGRSRQTACTPGDCPGELCPQDNGTACGSHCRGALPRAKGAFHMAGRVAEQLRNFNTQLQQTRQMIRAAEEAASRVQADAQRLETQVSTSRLLMEEDVQRTRLLIQQVRGFLTDPDTDAATIQQVSEAVLALWLPTDSATVLRKMKEIQAIAARLPNVDSVLSQTKQDIARARRLQAEAEQARSRAHAVEGQVDDVVGNLRQGTVALQEAQDTMQGTGRSLRLIQERVGEVQQVLVPAERLVKGMKEQMSGFWARMKELRRQAQEEQAQAMQARQLAEGASQQAMNAQEGFKRLKQKYTELKDRLGQSPVLGEQGNRILSIKMEAEELFGETMEMMDKMKDMESELLRGSQAIMLRSADLSGLEKRVEQIRSYINGRVLYYATCK
Protein: Proteasome subunit beta (Q9VUJ1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU004203}. Nucleus {ECO:0000256|RuleBase:RU004203}.
Interaction partners:
- Proteasome subunit beta
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-5
- Proteasome subunit beta type-1
- Proteasome subunit beta type-3
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-3
- Proteasome subunit beta
- Proteasome subunit alpha type-6
Sequence:
MDLDNARDLPRAGFNFDNCKRNATLLNRGFKPPTTTKTGTTIVGIIYKDGVILGADTRATEGPIVSDKNCAKIHYLAKNIYCCGAGTAADTEMTTDLISSQLELHRLQTDREVRVVAANTMLKQMLFRYQGHISAALVLGGVDKTGPHIYSIHPHGSSDKLPYATMGSGSLAAMTVFESRWKPDLSEEEGKKLVRDAIASGVFNDLGSGSNIDLCVIRKGSVEYLRNYELANKKGKRQLDYRFKTGTSTVLHTNIKDLLVTERVQAVPMEIS
Protein: Ribosome biogenesis protein WDR12 homolog (Pescadillo-interacting protein 2) (AtPEIP2) (Q9LF27)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
Subcellular location: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:23909681, ECO:0000269|PubMed:25443833}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
Interaction partners:
- Probable rRNA-processing protein EBP2 homolog
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Pescadillo homolog
- AT5g04600/T32M21_200
- Ribosome biogenesis protein BOP1 homolog
- Ribosome assembly factor mrt4
- Protein MAK16 homolog
- Transducin/WD40 repeat-like superfamily protein
- Nucleolar complex-associated protein 3
- Guanine nucleotide-binding protein-like NSN1
Sequence:
MDIDGEDVSRRLHVKFVTKLDSPFKVPVNSVAIPSNVTRLGLSSIVNSIIESENPEWKTEPFDFLIDGELIRMSLEEFLLAKGISAERTLEIEYIRAVTPRKEEEPSLHDDWVSAVNGSSPRFILTGCYDGLGRVWSSAGSCSHILEGHSGAISSVALVNSNDAETVTVATASKDRTLRLFKFDPAESVDSTTKVRAYKILRGHKASVQSVSAQKSGNMVCSSSWDCTINLWNTNESTSEGESVSVKKRKGNNQAEESQSEGEAVTSLVGHTQCVSSVVWPEHDVIYSSSWDHSVRRWDVETGKDSLNLFCGKALNTVDVGGESSALIAAGGSDPILRVWDPRKPGTSAPVFQFSSHSSWISACKWHKSSWFHLLSASYDGKIMLWDLRTAWPLSVIDTHNDKVLSADWWKGESVVSGGADSNLRISSGIAIS
Protein: Rme1p (Q59WD1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Transcription factor MBP1
- Transcriptional regulator
- G1/S-specific cyclin CLN3
- Mating-type-like protein A1
- Cell wall mannoprotein PIR1-like C-terminal domain-containing protein
- Hypha-specific G1 cyclin-related protein 1
- Csp1p
Sequence:
MFSYNLESNNAGYLNHHHSRHHLNSNSNSNNNNNNNNNNSIAISNNNKAHLQEQKQRQSQEHEQNPRNPQVYQNYHFIQQQQHFQYLQNALANTMSQLQHHPPYHGHAVFKPNYMQDVFLNDSCSLGSPVNSIENSGCTTTKTTPIISPMSLNDNVLPPPNHHDFDTFMGNNFVDYTSSYNPEHTLPSPSSPLTMVCNDGRRHDDHMNFASTFSVHPASSKCAIQHYGNSNQELTKGYPNPNSLVYNTTNNCINNNSNSNNNKYSSHEYKDTRMMEMATPESPHKRNSLPNTRVPIIPTSPTFPIALNLIHSNANTKRHKSLGSATSMLQPPLEDSRLMNSGHAEPMKKRLLSRFSSRLIQKLRLAESDMKCRKHCNTRFGNYLELIDHFEGHGLQRYLSSRTFICPVKECPMNMIGFDKRAELRHHVHSDHVTHGLVSIQYAKYSEEIKEFLFVCDEENCGKGFYRSDTLTRHIKLVHKREKHFTKRKRRQVVAHQEDKAIKKSKG
Protein: Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (O88450)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Transcriptional activator of EIF4G3. May also involved in behavior (By similarity).
Subcellular location: Nucleus. Secreted. Note=Secreted in some cell types.
Interaction partners:
- Coiled-coil and C2 domain-containing protein 1A
Sequence:
MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAESEAEEPVLSRDEDSEEDADSEAERETRRVTAVAVMAAESGHMDMGTEALPSPDEAAAAAAFAEVTTVTVANVGSSADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEAGVQPPCRVGHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPSTPTKAVSPTVVSGLEMSEHRSWLYLEEMVNSLLNTAQQLKTLFEQAKQASSCREAAVTQARMQVDAERKEQSCVNCGREAMSECTGCHKVNYCSTFCQRKDWKDHQHVCGQSASVTVQADDVHVEESVIEKVAV
Protein: Protein TIFY 10c (OsTIFY10c) (Jasmonate ZIM domain-containing protein 8) (OsJAZ8) (OsJAZ7) (Q69P94)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Repressor of jasmonate (JA) responses. Acts as a repressor of JA-induced resistance to the bacterial blight pathogen Xanthomonas oryzae pv. oryzae (Xoo). Regulates JA-induced accumulation of linalool at the transcriptional level of linalool synthase gene LIS. Linalool is important for resistance to bacterial blight pathogen Xoo.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:23104764}. Cytoplasm, cytosol {ECO:0000269|PubMed:23104764}. Note=Mainly localized in the nucleus. {ECO:0000269|PubMed:23104764}.
Interaction partners:
- Coronatine-insensitive protein homolog 1a
- Transcription factor MYC2
- Coronatine-insensitive protein homolog 1b
- Os10g0506950 protein
- Coronatine-insensitive protein homolog 2
- Protein TIFY 9
Sequence:
MAGRATATATAAGKDRSSFAVTCSLLSQFLKEKKGGGGGLQGLGLGLRPAPAAPPAAGAGGAFRPPPTTMNLLSGLDAPAVEVEPNTAETAADELPLIKAPADQQSDESASEAAGEKAQQLTIFYGGKVVVFENFPSTKVKDLLQIVSTGDGVDKNTGTAATQSLPRPAHNSLPDLPIARRNSLHRFLEKRKGRMNANAPYQANCTAAPSKQANGDKSWLGFGQEMTIKQEI
Protein: Disease resistance-like protein CSA1 (EC 3.2.2.6) (Protein CONSTITUTIVE SHADE-AVOIDANCE 1) (F4KIF3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TIR-NB-LRR receptor-like protein that functions in photomorphogenic development. May function downstream of phytochrome B (phyB) signaling.
Interaction partners:
- Protein DA1-related 4
- Transcription elongation factor
- Protein DWD HYPERSENSITIVE TO UV-B 1
- Apoptosis inhibitory protein
- AT3g05090/T12H1_5
Sequence:
MTSSSSWVKTDGETPQDQVFINFRGVELRKNFVSHLEKGLKRKGINAFIDTDEEMGQELSVLLERIEGSRIALAIFSPRYTESKWCLKELAKMKERTEQKELVVIPIFYKVQPVTVKELKGDFGDKFRELVKSTDKKTKKEWKEALQYVPFLTGIVLDEKSDEDEVINIIIRKVKEILNRRSEGPPSKCSALPPQRHQKRHETFWGIELRIKQLEEKLRFGSDETTRTIGVVGMPGIGKTTLATMLYEKWNDRFLRHVLIRDIHEASEEDGLNYLATKFLQGLLKVENANIESVQAAHEAYKDQLLETKVLVILDNVSNKDQVDALLGERNWIKKGSKILITTSDKSLMIQSLVNDTYEVPPLSDKDAIKHFIRYAFDGNEGAAPGPGQGNFPKLSKDFVHYTKGNPLALQMLGKELLGKDESHWGLKLNALDQHHNSPPGQSICKMLQRVWEGSYKALSQKEKDALLDIACFRSQDENYVASLLDSDGPSNILEDLVNKFMINIYAGKVDMHDTLYMLSKELGREATATDRKGRHRLWHHHTIIAVLDKNKGGSNIRSIFLDLSDITRKWCFYRHAFAMMRDLRYLKIYSTHCPQECESDIKLNFPEGLLLPLNEVRYLHWLKFPLKEVPQDFNPGNLVDLKLPYSEIERVWEDNKDAPKLKWVNLNHSKKLNTLAGLGKAQNLQELNLEGCTALKEMHVDMENMKFLVFLNLRGCTSLKSLPEIQLISLKTLILSGCSKFKTFQVISDKLEALYLDGTAIKELPCDIGRLQRLVMLNMKGCKKLKRLPDSLGQLKALEELILSGCSKLNEFPETWGNMSRLEILLLDETAIKDMPKILSVRRLCLNKNEKISRLPDLLNKFSQLQWLHLKYCKNLTHVPQLPPNLQYLNVHGCSSLKTVAKPLVCSIPMKHVNSSFIFTNCNELEQAAKEEIVVYAERKCHLLASALKRCDESCVPEILFCTSFPGCEMPSWFSHDAIGSMVEFELPPHWNHNRLSGIALCVVVSFKNCKSHANLIVKFSCEQNNGEGSSSSITWKVGSLIEQDNQEETVESDHVFIGYTNCLDFIKLVKGQGGPKCAPTKASLEFSVRTGTGGEATLEVLKSGFSFVFEPEENRVPSPRNDDVKGKVKINKTPSANGCFKDQAKGNESPKGQWQTYIENSSTNIPSEAHSSQKTGFNGFNGMYSVCVLYEMYSH
Protein: Large ribosomal subunit protein P2x (60S acidic ribosomal protein P2-3) (Q9LH85)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays an important role in the elongation step of protein synthesis.
Interaction partners:
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein uL4z
- Large ribosomal subunit protein uL4y
Sequence:
MKVIAAFLLAKLGGNENPTSNDLKKILESVGAEIDETKIDLLFSLIKDHDVTELIAAGREKMSALSSGGPAVAMVAGGGGGGAASAAEPVAESKKKVEEVKDESSDDAGMMGLFD
Protein: Heat shock factor-binding protein 1 (Q9CQZ1)
Organism: Mus musculus (Mouse)
Function: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Heat shock factor protein 1
- WASH complex subunit 3
- E3 ubiquitin-protein ligase RBX1
Sequence:
MAETDPKTMQDITLVVETLLQQMQDKFQIMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELDPENKIPTAQKS
Protein: SNAPIN protein homolog (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Q9VQF9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9Z266}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z266}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z266}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Dysbindin protein homolog
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- BLOC-1-related complex subunit 5
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- BLOC-1 related complex subunit 6, isoform A
- KxDL motif-containing protein CG10681
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Synaptosomal-associated protein 25
Sequence:
MDSDSTVTSLEENTENFCTNPTRDILAEGITNLFKPTIERLDERVASTIQLQAELRGQLDALAAQLRDIEKAQSQIPEFADKVKELLNVKHKVTVISNVLVTSQERLTGLHKLIEKEQRRRQALLDSALSTNIS
Protein: Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (P54284)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:34234349}.
Interaction partners:
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Voltage-dependent calcium channel subunit alpha-2/delta-1
- Voltage-dependent calcium channel subunit alpha-2/delta-4
- Voltage-dependent R-type calcium channel subunit alpha-1E
- Voltage-dependent L-type calcium channel subunit alpha-1F
- Voltage-dependent L-type calcium channel subunit beta-4
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Voltage-dependent calcium channel gamma-4 subunit
Sequence:
MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWPKDSY