wanglab/gogpt-training-data huggingface dataset:
Protein: Proteasome subunit beta type-4 (Low molecular mass protein 3) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (Proteasome subunit beta-7) (beta-7) (P99026)
Organism: Mus musculus (Mouse)
Function: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P28070}. Nucleus {ECO:0000250|UniProtKB:P28070}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P28070}.
Interaction partners:
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-5
- Proteasome subunit beta type-6
- Proteasome subunit beta type-8
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-7
- Proteasome subunit beta type-9
- Proteasome subunit beta type-10
Sequence:
MEAFWESRAGHWAGGPAPGQFYRIPATPSGLMDPASAPCEGPITRTQNPMVTGTSVLGVKFDGGVVIAADMLGSYGSLARFRNISRIMRVNDSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARELVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSAQTNWDIAHMISGFE
Protein: Defective proboscis extension response 21 (A0A0C4DHN4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LP09246p
- Protein CNPPD1
Sequence:
MKVFLTFRIFLCILILKETCPQHFRENVTVTDLYLISENIVPMKRVLDRGPYFDTSATKNVTSLVGITGHLNCRIKNLGNKTVSWIRHRDLHLLTVSESTYTSDQRFTSIYNKQTGDWSLQIKFPQLRDSGIYECQVSTTPPVGYTMVFSVVEPITSILGGPEIYIDLGSTVNLTCVIKHLPDPPISVQWNHNNQEINYDSPRGGVSVITEKGDITTSYLLIQRASIADSGQYTCLPSNANSKSVNVHILKGDHPAAVQKSHLLVSELLSLCFLQICLNLST
Protein: Uncharacterized protein C458.02c (Q9P3W6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSSHKPVRPNEALHKEALEELDAKINEAKKRFNEHKEKLGAIRGGGSLQEKNAELRAELDNIRNAQAAIRSSKQTLINKVKAQDELLKKKVKELTAMKKTVPFKSEVELDKHVKQLQAAVDSGTLKIVDEKKYLREISQCNRTRKSFVELNALQTSIDTIRNELNELRDQLNDSESKKLSDKFVEIRSELDEVRKQQDGYYKDQRKLIAERDDEKTALDDLYNQRRALQREYDTQLRAFRTYEREQRAKRQEQFRLERENREKEKRRIAAQRKLEEASIPAFTEEILACENLLKVFHVPVESSTTNAVSTGNTSSKILKPRTLTPRTVDPIPEGTIIKKESSDDAMFSGLKKSKPKKSNKSNNNQADSDRLNLSFGTIKEFDFVGVPAPFTKSQVDSAVEQLKSRIAHFKEQQDSVTKQRIEKAKQEIEKLEAKYNSKEEKTLTEADMVISSEETVTVTNDLEVEATA
Protein: Sensor protein PfeS (EC 2.7.13.3) (Q04804)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Member of the two-component regulatory system PfeR/PfeS. May activate PfeR by phosphorylation.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Transcriptional activator protein PfeR
- Two-component response regulator
- Iron
- Ferric enterobactin receptor
- histidine kinase
- Probable sigma-70 factor, ECF subfamily
- Probable two-component response regulator
- Transcriptional regulatory protein AruR
- Probable two-component response regulator
- Transcriptional regulatory protein GltR
Sequence:
MRRHPLLWKLALLQVGFCLLLTWLIYTWGLSVERSTYFLAPADRHYLADYARQAEDAWRREGAAGAERFRKELSAKEDTWVALVGPHLESLGSTPLSAEESSHLTFMRKLDWPMSRRLQDELPYVSIEFPGHPEQGRLVIQLPERLLPGGLTPWTHLVTHGIVPTLLAALLGLLLYRHLVVPLNRLRDRADALRADELESTPLAAPLAARRDELGELAQALEHMAERLRLSLAQQRLLLRTLSHELRTPLARLRIAHDSELPPEQLRQRLDREIGDMQRLLEDTLDLAWMDTERPQLPTEPVLALSVWEALRDDACFESGWDPARLPCRLGVDCRVEVHLDSLAQAMENLLRNAIRHSPEDGTVSLDGEREGDFWHLRLQDQGPGVAEDQLERIFLPYQRLDDSAGEGFGLGLAIARRAIELQGGRLWASNGKPGLCLHLWLPAAA
Protein: Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125) (Q01344)
Organism: Homo sapiens (Human)
Function: Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Interleukin-5
- Cytokine receptor common subunit beta
- Interleukin-3
- Granulocyte-macrophage colony-stimulating factor
- Interleukin-4
- Syntenin-1
- Interleukin-2
- Interleukin-13
- Interleukin-2 receptor subunit beta
- Tyrosine-protein kinase JAK2
Sequence:
MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRNVNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQIEKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGNDEHKPLREWFVIVIMATICFILLILSLICKICHLWIKLFPPIPAPKSNIKDLFVTTNYEKAGSSETEIEVICYIEKPGVETLEDSVF
Protein: Probable glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) (Q9Y7Y8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative proline--tRNA ligase C19C7.06
- Isoleucine--tRNA ligase, cytoplasmic
- Putative leucine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, cytoplasmic
- Isoleucine--tRNA ligase, mitochondrial
- Probable proline--tRNA ligase, mitochondrial
- Probable methionine--tRNA ligase, cytoplasmic
- tRNA-aminoacylation cofactor arc1
- Glutamyl-tRNA
- Lysine--tRNA ligase, mitochondrial
Sequence:
MDQDYEELRAKFTKIGLNETTVKDTLKNKKLSSSLNKVIEETNVGSSGCDRTIGNLLFTLANASLKQKDPKSNAHEAFIASKIVSGDLKTNLQVNAAITYCKDKDTIDESEFDKETGVGVVLTPEQIEQLVGDYVAENKSKILEQRYQLLNPSASALRQHALLKWAPQLEVKQTLDRKFLELLGPKTEQDAAAGKKKGAKAKNSKQKTVDSGKAKEQKIVSEQSKKYNMFEEGFLAKLHKPGGNTQLIPERMKEHLQATGGGVVTRFPPEPNGYLHIGHSKAIAVNFGFARYHNGVCYLRFDDTNPEAEEERYFESIKDLVAWLGFQPYKITYSSDYFDKLYELAEELIKRDKAYVCHCTDAEIKKARGGEERGPRYACVHRDRPIEESLLEFRNMRDGKYQPKEAILRMKQDLSDGNPQMWDLIAYRVLNSPHPRTGDKWKIYPTYDFTHCLVDSFENISHSLCTTEFILSRVSYEWLCNALEVYCPAQREYGRLNVVGTLMSKRKIMKLVKEGYVHGWNDPRLYTLVALRRRGVPPGAILEFVSEVGVTTAVSNIEVARFENCVRKFLENSVPRLMFLPDPIKVTLENLDDSYREQIEIPFNPKDPSMGSRSAFLTKHIYIDRSDFREEASSDFFRLTLGQPVGLFRASHPVVAKRVVKNDEGEPIEIIAEYDASSSKKPKTFIQWVSRDKESNSPVLIAETRLFNNLFKCDNPAALKEQELAAQLNPESEVVLKNSIIEPGIYDLIKSAPWPKTDSSAGVDKAENPESVRFQAMRVGYFCLDEDTKKPNHLVLNRIVSLREDSAKNKN
Protein: ABI family member 3 binding protein (E9Q8E3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLSSLGCLLLCGSIALALGNAQKLPKGKKPSLKVHINTTSDSILLKFLRPNANVKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVVDAEPKYLIVVRPAPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHDWTLPSHCPSDRFYTIRYREKDKEKKWIFQLCPATETIVENLKPNTVYEFGVKDNIEGGIWSKIFNHKTIVGSKNKVNGKIQSTYDQVHSVPVPRKLIPLTIIKQVIQNVTHRASTKSPDKTPFGGTILVHLIIPGLNESTVKLPTSIMLEISDALKAQLAKNETLALPAESKTPEVEKLAGQPVTVTPESVSRSTKPTLSSALDTAETALAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLIPVISPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPISAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFLDGRTGQQLTSEQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9VUV4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- M-phase inducer phosphatase
- Cdc25-like protein phosphatase twine
- non-specific serine/threonine protein kinase
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
- Wee1-like protein kinase
- Anaphase-promoting complex subunit 10
- LD22609p
- Protein arginine N-methyltransferase 5
- Liprin-gamma, isoform C
Sequence:
MQKENNVTAENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSYGQISEGSPLTPRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQANAISRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGIPPGSPGGNSSGSTSASPSVHHRANSGPTIAISMFHDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPGGQLWKTRLTNIKNSFLGSPRFHRRKMQVSADEVHLTPESSPELTKRSWFGNLITTEKDETFTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKRNGNGPVMFQRHVKFQVDISAICKQGDIADMLFALTFTLLSGNIRRFRRICEHIQSQVCSKRFPGPSSPPTVTSVTQAVSESSSCGSVSSERLSYKRQVIENDMENDSIFSYKSGNGRRASTTNNNNANPVDIPGSPIAVRSNSETAEHERNRELQSERQATTMSGSAIA
Protein: RING finger protein 122 (Q9H9V4)
Organism: Homo sapiens (Human)
Function: May induce necrosis and apoptosis. May play a role in cell viability.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:16778963}. Endoplasmic reticulum {ECO:0000269|PubMed:16778963}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MHPFQWCNGCFCGLGLVSTNKSCSMPPISFQDLPLNIYMVIFGTGIFVFMLSLIFCCYFISKLRNQAQSERYGYKEVVLKGDAKKLQLYGQTCAVCLEDFKGKDELGVLPCQHAFHRKCLVKWLEVRCVCPMCNKPIASPSEATQNIGILLDELV
Protein: Mitochondrial phosphate carrier protein 1, mitochondrial (Mitochondrial phosphate transporter 1) (MPT1) (Phosphate transporter 3;3) (Q7DNC3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Mediates salt stress tolerance through an ATP-dependent pathway and via modulation of the gibberellin metabolism.
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Probable anion transporter 4, chloroplastic
- Probable inorganic phosphate transporter 1-6
- Probable inorganic phosphate transporter 1-3
- Probable inorganic phosphate transporter 1-2
- Inorganic phosphate transporter 2-1, chloroplastic
- Probable anion transporter 3, chloroplastic
- ADP,ATP carrier protein 1, mitochondrial
- ADP,ATP carrier protein 2, mitochondrial
- Probable inorganic phosphate transporter 1-8
- Probable inorganic phosphate transporter 1-7
Sequence:
MTRVKSKLDEELSSPWFYTVCTMGGMLSAGTTHLAITPLDVLKVNMQVNPVKYNSIPSGFSTLLREHGHSYLWRGWSGKLLGYGVQGGCRFGLYEYFKTLYSDVLPNHNRTSIYFLSSASAQIFADMALCPFEAIKVRVQTQPMFAKGLLDGFPRVYRSEGLAGFHRGLFPLWCRNLPFSMVMFSTFEQSVEFIYQKIIQKRKQDCSKAQQLGVTCLAGYTAGAVGTIISNPADVVLSSLYNNKAKNVLQAVRNIGFVGLFTRSLPVRITIVGPVITLQWFFYDAIKVLSGFPTSGGVKKPVDAAKLSV
Protein: ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2) (Q9H221)
Organism: Homo sapiens (Human)
Function: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG5 has ATPase activity.
Subcellular location: Cell membrane {ECO:0000305|PubMed:16893193}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}. Apical cell membrane {ECO:0000269|PubMed:14504269}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}.
Interaction partners:
- ATP-binding cassette sub-family G member 5
- Lysosomal cobalamin transporter ABCD4
- ATP-binding cassette sub-family B member 6
- ATP-binding cassette sub-family A member 2
- Sterol regulatory element-binding protein 2
- Oxysterols receptor LXR-alpha
- Solute carrier family 53 member 1
- NPC1-like intracellular cholesterol transporter 1
- Oxysterols receptor LXR-beta
- Cytochrome P450 7A1
Sequence:
MAGKAAEERGLPKGATPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYVSLRFIKQKPSQDW
Protein: Protein MALE DISCOVERER 1 (AtMDIS1) (Probable LRR receptor-like serine/threonine-protein kinase At5g45840) (EC 2.7.11.1) (C0LGU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the pollen tube perception of the female signal.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26863186}; Single-pass type I membrane protein {ECO:0000305}. Endomembrane system {ECO:0000269|PubMed:26863186}. Note=LURE1.2 binding triggers endocytosis in the pollen tube tip. {ECO:0000269|PubMed:26863186}.
Interaction partners:
- Inositol 3-kinase
- Protein LURE 1.2
- MDIS1-interacting receptor like kinase 1
- MDIS1-interacting receptor like kinase 2
- Cysteine rich peptide
- Cysteine rich peptide
- Protein LURE 1.1
- Protein LURE 1.6
- Protein LURE 1.5
Sequence:
MGCRWNPIGFQFSCFMFLIITLQSRSSLSLESEGFVLLKFRARVDSDPHGTLANWNVSDHDHFCSWFGVTCVDNKVQMLNLSGCSLGGTLAPELSQLSELRSLILSKNKLSGDIPNEFASFAKLEFLDLRDNNLNGVVPPELNKVLTPENLLLSGNKFAGFMTVKFLRLQSLYKVQMNKNRELSSVSADVLDCVNRKLGYCVSRRSLITRNKAKAFVLRIRATSRHYMVRRESHGKNYVVNYHPSENETSIFKRRELLEETSNLAAMPAPDTPSPSPEIITIVFPRSSGSFPALTNAKKRIPPLIPPSSPPPLPTNNTIASDPPRKFEEKSKGFKDVWLYVVIGVAAFVAMLIIVAVIFFFRKRAVKSIGPWKTGLSGQLQKAFVTGVPKLNRSELETACEDFSNIIEAFDGYTVYKGTLSSGVEIAVASTAILETREWTRAMEMTYRRRIDTMSRVNHKNFINLIGYCEEDEPFNRMMVFEYAPNGTLFEHLHDKEMEHLDWNARTRIIMGTAYCLQYMHELNPPISHTKLVSSAIYLTDDYAAKVGEVPFSGQTGSKPRKPMSGDLDQSLLPLPPEPETNVYSFGVLMLEIISGKLSDSEEEGSILKWASKYLENDNLRDMIDPTLTTYKEEELEAICDVARHCLKLDESQRPKMKYVVQQLKEVINISQEQATPRLSPLWWAELEILSSEAT
Protein: Insulin-like domain-containing protein (Insulin-like peptide) (G5EFY8)
Organism: Caenorhabditis elegans
Subcellular location: Secreted {ECO:0000256|RuleBase:RU000406}.
Interaction partners:
- Insulin-like receptor
- Uncharacterized protein
- Insulin-like peptide 7
- Probable insulin-like peptide beta-type 5
- Forkhead box protein O
- Ceinsulin-1
- Dauer larva development regulatory growth factor daf-7
- Probable insulin-like peptide beta-type 1
Sequence:
MYWFRQVYRPSFFFGFLAILLLSSPTPSDASIRLCGSRLTTTLLAVCRNQLCTGLTAFKRSADQSYAPTTRDLFHIHHQQKRGGIATECCEKRCSFAYLKTFCCNQDDN
Protein: Sarcoma antigen 1 (Cancer/testis antigen 14) (CT14) (Q9NXZ1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:31429579}.
Interaction partners:
- Probable ATP-dependent RNA helicase DDX43
- Sperm surface protein Sp17
- Melanoma-associated antigen C2
- Probable threonine protease PRSS50
- demerged
- P antigen family member 5
- Melanoma-associated antigen 1
Sequence:
MQASPLQTSQPTPPEELHAAAYVFTNDGQQMRSDEVNLVATGHQSKKKHSRKSKRHSSSKRRKSMSSWLDKQEDAAVTHSICEERINNGQPVADNVLSTAPPWPDATIAHNIREERMENGQSRTDKVLSTAPPQLVHMAAAGIPSMSTRDLHSTVTHNIREERMENGQPQPDNVLSTGPTGLINMAATPIPAMSARDLYATVTHNVCEQKMENVQPAPDNVLLTLRPRRINMTDTGISPMSTRDPYATITYNVPEEKMEKGQPQPDNILSTASTGLINVAGAGTPAISTNGLYSTVPHNVCEEKMENDQPQPNNVLSTVQPVIIYLTATGIPGMNTRDQYATITHNVCEERVVNNQPLPSNALSTVLPGLAYLATADMPAMSTRDQHATIIHNLREEKKDNSQPTPDNVLSAVTPELINLAGAGIPPMSTRDQYATVNHHVHEARMENGQRKQDNVLSNVLSGLINMAGASIPAMSSRDLYATITHSVREEKMESGKPQTDKVISNDAPQLGHMAAGGIPSMSTKDLYATVTQNVHEERMENNQPQPSYDLSTVLPGLTYLTVAGIPAMSTRDQYATVTHNVHEEKIKNGQAASDNVFSTVPPAFINMAATGVSSMSTRDQYAAVTHNIREEKINNSQPAPGNILSTAPPWLRHMAAAGISSTITRDLYVTATHSVHEEKMTNGQQAPDNSLSTVPPGCINLSGAGISCRSTRDLYATVIHDIQEEEMENDQTPPDGFLSNSDSPELINMTGHCMPPNALDSFSHDFTSLSKDELLYKPDSNEFAVGTKNYSVSAGDPPVTVMSLVETVPNTPQISPAMAKKINDDIKYQLMKEVRRFGQNYERIFILLEEVQGSMKVKRQFVEFTIKEAARFKKVVLIQQLEKALKEIDSHCHLRKVKHMRKR
Protein: Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) (O00267)
Organism: Homo sapiens (Human)
Function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
Subcellular location: Nucleus {ECO:0000269|PubMed:10075709}.
Interaction partners:
- RNA polymerase-associated protein CTR9 homolog
- DNA-directed RNA polymerase II subunit RPB4
- RNA polymerase-associated protein RTF1 homolog
- DNA-directed RNA polymerase II subunit RPB2
- Transcription elongation factor SPT6
- Negative elongation factor A
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB1
- Parafibromin
- Transcription elongation factor SPT4
Sequence:
MSDSEDSNFSEEEDSERSSDGEEAEVDEERRSAAGSEKEEEPEDEEEEEEEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKEREHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQNNIHVKDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRGGFGSPGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYGSQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIVRMDLDEQLKILNLRFLGKLLEA
Protein: INSIG protein homolog (MvINS) (A1T557)
Organism: Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii)
Function: Diacylglycerol-binding protein.
Subcellular location: Membrane {ECO:0000269|PubMed:26160948}; Multi-pass membrane protein {ECO:0000269|PubMed:26160948}.
Interaction partners:
- Conserved hypothetical alanine and proline rich protein
- ESX-1 secretion-associated protein
Sequence:
MRLRISEAVVLFLLGAVAALIGDHSHVVTGTTVYHTDAVPFVWSSPFWFPILVGAATASLAELRLHLPAPRDGVTARQALGGVAAVVGTYVTTALVHAFPVVPVTALVCAAAAITWCVLGDGPGAACGVVIAVIGPAVEIALVQLGVFAYHPDSDGLFGVAPFLAPLYFAFGVVAALLGELAVARRPQLGPPVCDTVSRGPGAG
Protein: Protein SIA1 (Q12212)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the activation of the plasma membrane proton-ATPase (PMA1) by glucose.
Interaction partners:
- Phosphate system positive regulatory protein PHO81
Sequence:
MRLHYRRRFNFLRRILFILCITSLYLSRDSLKLHAKNVLMDHNVAEYHGGMIDDIQILRCYHWYRQCSSLYAPKLHPSNTAKKIKDKNSILWTRVSKNITVETLYSLQSGPFYNSYLYVHLKDFQSNPKNTIKELAIARDSALIPLQVLRDINKLVKSSDSSVFHNHVYLREKPTSSWWKLLFGISVDTDNIAVFGEEWVYKGSGIWCKYILNDDDNDAPITNLEIYLGSSFIESRPSWKEVIHEFHRNNIPSLPISITRKLETKNHHHKFSNGLLGSLRTPSKDINIQVDADYKITSPHIQFSRGQRSFKILQITDFHFKCTDNSMTVINEIKTVNFIDRVLASENPDLVVITGDLLDSHNTIDYQTCIMKVVQPMISNKIPYAISLGVSDESNLATSAQIRDFIRNLPYTFNNVASEEGHMAIEVSFKKKLTKNTLLERDIDTEDETNPSEALFFVFDSFAPVNNFLQDYNDLIGKIDFGLAFQYFPLSEYRPHGLFPIIGQYNERSTLTVDTPRSRGQVSMTINGKHYKSFLDILSLWNIKGVSCGHEHNNDCCLQSKNEMWLCYGGSAGIGLPRIQGIYPTVRLFNLDDILDEITSWKRNSNLVDEVYDYQYIYKGKQ
Protein: Elastin (Tropoelastin) (P04985)
Organism: Bos taurus (Bovine)
Function: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P15502}. Note=Extracellular matrix of elastic fibers. {ECO:0000250|UniProtKB:P15502}.
Interaction partners:
- Fibrillin-1
- Protein-lysine 6-oxidase
- Microfibrillar-associated protein 2
- Fibulin-5
- Fibronectin
- Decorin
- Lysyl oxidase homolog 1
- Fibulin-2
- Microfibrillar-associated protein 5
- Biglycan
Sequence:
MRSLTAAARRPEVLLLLLCILQPSQPGGVPGAVPGGVPGGVFFPGAGLGGLGVGGLGPGVKPAKPGVGGLVGPGLGAEGSALPGAFPGGFFGAGGGAAGAAAAYKAAAKAGAAGLGVGGIGGVGGLGVSTGAVVPQLGAGVGAGVKPGKVPGVGLPGVYPGGVLPGAGARFPGIGVLPGVPTGAGVKPKAQVGAGAFAGIPGVGPFGGQQPGLPLGYPIKAPKLPAGYGLPYKTGKLPYGFGPGGVAGSAGKAGYPTGTGVGPQAAAAAAKAAAKLGAGGAGVLPGVGVGGPGIPGAPGAIPGIGGIAGVGAPDAAAAAAAAAKAAKFGAAGGLPGVGVPGVGVPGVGVPGVGVPGVGVPGVGVPGVGVPGVGVPGVGVPGVGVPGVGVPGALSPAATAKAAAKAAKFGARGAVGIGGIPTFGLGPGGFPGIGDAAAAPAAAAAKAAKIGAGGVGALGGVVPGAPGAIPGLPGVGGVPGVGIPAAAAAKAAAKAAQFGLGPGVGVAPGVGVVPGVGVVPGVGVAPGIGLGPGGVIGAGVPAAAKSAAKAAAKAQFRAAAGLPAGVPGLGVGAGVPGLGVGAGVPGLGVGAGVPGPGAVPGTLAAAKAAKFGPGGVGALGGVGDLGGAGIPGGVAGVVPAAAAAAKAAAKAAQFGLGGVGGLGVGGLGAVPGAVGLGGVSPAAAAKAAKFGAAGLGGVLGAGQPFPIGGGAGGLGVGGKPPKPFGGALGALGFPGGACLGKSCGRKRK