wanglab/gogpt-training-data huggingface dataset:
Protein: Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) (Q7Z2Z1)
Organism: Homo sapiens (Human)
Function: Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:20080954}. Note=Associates with chromatin.
Interaction partners:
- DNA topoisomerase 2-binding protein 1
- Cell division control protein 45 homolog
- Mdm2-binding protein
- Protein DBF4 homolog A
- ATP-dependent DNA helicase Q4
- Protein MCM10 homolog
- DNA replication licensing factor MCM4
- Cell division cycle 7-related protein kinase
- DNA replication complex GINS protein SLD5
- DNA replication complex GINS protein PSF3
Sequence:
MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVHWAFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPCPHSQRELLQFVSGCEAQAQRLPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNRLLYNSPEYEASFPRMEGMLFLPVEAGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPEESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASLFSDVVDSILNQTHDSLADTASAASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKEESSKTEGELIHCLAELYQRKSREESTIAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVAGEKGIQKIPSGRTVDKLEDRGRTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTKELEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPESDELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQPVKDTVQEVTKVRRNLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLSFSRTHSASFYSVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTADAEKSSLSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTDSASPQTYEVELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWTPSPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLELSIHRTPILEDFELEGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEADRGAKRICDLREDSEVSKSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSASALQALTQSPLLFQGKTPSSQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRKKLMGTWLEDL
Protein: Auxin canalization protein (DUF828) (Q9LUI0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein LAZY 1
- Protein SHI RELATED SEQUENCE 7
- Protein RALF-like 16
- Calcium-binding protein PBP1
Sequence:
MEKPVFAPWRSDQVFRPPETPLEPMEFLSRSWSVSAHEVSKALTPSQQLLSKASIENTTVILEEPIAAGETETEDNSFVSGNPFSFACSETSQMVMDRILSQSQEVSPRTSGRLSHSSGPLNGSLTDSPPISPHQVDDIKQFCRSNNNFNSQYRSTGTTPGPITATTTQSKTVGRWLKDRREKKKEEMRAHNAQIHAAVSVAGVAAAVAAIAAATAASSSAGKDENMAKTDMAVASAATLVAAQCVEAAEVMGAERDHLASVVSSAVNVRSAGDIMTLTAGAATALRGVATLKARAMKEVWHIASVIPMDKGINLGGCSNVNGNGSYVSSSSSHSGEFLVEDNFLGHCNREWLARGGQLLKRTRKGDLHWKIVSVYINRLNQVILKMKSRHVGGTFTKKNKNVVIDVIKNVQAWPGRHLLEGGEDLRYFGLKTVPRGIVEFQCKSQREYEMWTQGVSRLIAVAAERNNRYRI
Protein: Uncharacterized protein C11D3.15 (Q10094)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized protein C11D3.14c
- Glutamate--cysteine ligase
- Putative glutamate--cysteine ligase regulatory subunit
- Glutathione-specific gamma-glutamylcyclotransferase
- Glutathione hydrolase proenzyme 2
- Glutathione hydrolase proenzyme 1
- Probable NAD-specific glutamate dehydrogenase
- NADP-specific glutamate dehydrogenase
- Probable peptide transporter ptr2
- Glutamate synthase
Sequence:
MSVKIHIDRGGTFTDAIATFADESRPPIVIKLLSEDPSNYKDASIEAVRRILEIVQGKSIPRTEKLDTSCINHLRCGTTVATNALLERKGERCAFITTKGFKDGLLIGNQSRPNIFELGIRRPEVLYSKVIEVDERVTLEDYVEDPMKVKTTIDGSDPSLVVGRSGEVVRIMKKVDCDALRKDLQALYDEGFTSIAVCLAHSFTFPDHELLVGKIAEEVGFSNISLSTKLMPMIKYVPRATSATADAYLSPVVRRYLAGFQSGFLHGLKTKDNSKGVRCEFMQSDGGLVDVNKFSGLHAILSGPAGGVVGFALTSYDEDVKIPVIGFDMGGTSTDVSRYGGSYEHVFETTTAGVTIQSPQLDINTVAAGGGSRLFWKNGLFVVGPESAGAHPGPVCYRKGGYLTVTDANLLLGRLLPESFPKIFGPNEDESLDVESTRKEFEKLTAEINSGLEKERQMTADEVAFGFIKIANETMARPIRALTEAKGHDISIHRLTSFGGAGGQHCAAIAKSLGITQVLVHKYSSILSAYGMALADVVSEVQEPSSFTLDDSNTESIKKRFDSLKEEAKANLEEQGFTESQISYELFLNCRYQGTDSTLMISKPLESWDFKQSFFDKHKQEFGFIFENKDIIIDDIRIRASGKSFQSKEPSVDAQLKELKFEPVQKSLATCVKDIYFEGGRVPSEVYSLDNLPVGTIVNGPSLIVDKTQTIVVPPKAVARILHTHVVIDISHGNEYTANDSLAKASTIDPIYLSVFGSRFMAVAEQMGRALQKTSVSTNVKERLDYSCALFDAKGNLVANAPHMPVHLGSMSTCVRTQAKIHEGKLKPGDVLVTNHPSYGGTHLPDITTITPHFEGDEIMFYVAARAHHADIGGILPGSMPSSSKELSEEGATIKSEKLVVDGVFQEERMIDLLYNEPAKVEGGSGSRCLRDNLNDLKAQVSANQKGINLITSLIKEYGKNSVLRYMKAIQENAESAVRQLLLGVRERFLGEDLYAEDHMDDGSKICLRITIDEENGDAIFDFTGTTEEIYGNINAPEAVTYSAIIYCLRVLISENIPLNQGCLLPIKVIIPDNCFLKPSETAAVVGGNVLTSQRITDTILKAFQACAASQGDTNNLTFGIGGKDPETGEVKPGFGYYETICGGSGAIDGLDGTSGVHTHMTNTRITDLEVLERRYPVILRKFIIRENSGGAGKYKGGDGVIRDIEFRIPVTLSILSERRAYHPYGMKGGKDAECGKNIWIRKDILPSGEQRVRQINVGGKNTCHMQAGDHIVIMTPGGGGYGPPSERVDTVKKANGVQHFRANGTISQLQEIQHTN
Protein: Inactive chitinase-like protein 2 (HbCLP2) (allergen Hev b 11) (W0IWL0)
Organism: Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Function: Inactive chitinase-like protein that does not exhibit hydrolytic activity toward chitin. Binds strongly to chitin and possesses antifungal activity toward the fungal pathogen Altenaria alternata in plate assays. Probably involved in defense against fungal pathogens through a mechanism that only involves carbohydrate binding.
Interaction partners:
Sequence:
MKEIVRALEGYGPPKDKAAEQCGWQAGGALCPGGLCCSQYGWCANTPEYCGSGCQSQCDGGVGGEGGCVDLGCANTPEYCGSGCQSQCDGGVGGEGGCVDLGSIISRSTFEEMLKHRNNAACPAKGFYTYDAFISAAKAFPAFGTTGDVDTCKREIAAFFGQTSHATTGGWPTAPDGPYAWGYCHKEELNQASSYCSPSPAYPCAPGKKYYGRGPIQLSWNYGQCGQALGLDLLNNPDLVATDRVISFKAAIWFWMTPQFPKPSCHDVITGQWSPTGHDISAGRAPGYGVITNIINGGLECGRGWDARVEDRIGFYKRYCDMFGVGYGSNLDCYNQTPFGLG
Protein: Ovalbumin-related protein X (Gene X protein) (P01013)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Ovomucoid
- Ovotransferrin
- Ovotransferrin
- Uncharacterized protein.
- Ovostatin
- Protein TENP
Sequence:
QIKDLLVSSSTDLDTTLVLVNAIYFKGMWKTAFNAEDTREMPFHVTKQESKPVQMMCMNNSFNVATLPAEKMKILELPFASGDLSMLVLLPDEVSDLERIEKTINFEKLTEWTNPNTMEKRRVKVYLPQMKIEEKYNLTSVLMALGMTDLFIPSANLTGISSAESLKISQAVHGAFMELSEDGIEMAGSTGVIEDIKHSPESEQFRADHPFLFLIKHNPTNTIVYFGRYWSP
Protein: Oligodendrocyte transcription factor 1 (Q5QJR2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MQAVSGVRYREQGESSLQQLMPRMVRVTGSGGPGSNVGSLQGPLRSSKPPRELSSEEQQELRRKINSRERKRMQDLNVAMDALREVMVPYSSSPTGVGGALQHPYFPPGAPTTGRRLSKISTLVLARNYILLLGSSLQEMRRLLGEVSIGMGVSGTVPRLLLTGGWPFLTGPGQLLLSPPEQQLGVAKCPLLPQGAQEEPLAWGPGSMSESPVCQCGVCRTPRVVHVNPAMRFPK
Protein: SAM complex subunit (Q5ALP4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
Interaction partners:
- SAM complex subunit
- SAM complex subunit
- Sam51p
- Translocase of outer membrane 40 kDa subunit
- Mitochondrial distribution and morphology protein 10
- Tom6p
- Mitochondrial import receptor subunit TOM20
- Tom22p
- Mitochondrial Rho GTPase 1
- Goa1p
Sequence:
MLQLHVWGKDNEISIISPSCIASAYLLNQVLTPQNIEFEIIPSNNTNLSDINQLPVLIDNETKEKYNGYNEIIRFIESKYLSTSTKLSLVSYLPSDSLKTTKEKLINKGLINLLINKFEYINQYNLYLNNKNYENYTRKLFSSYLPFPMMYNQPSKYYAQAQEQVKILGLSKQKVSFFDFTTGNNEQGSIDVAPTELINDEDDEEGDEDEDGANVAISSLHERQLLKKSKSKQVLKESRNSMKCLILITQYIERFKTIFQHQQRDSDEEFGFIFNNQNPSSSEILFYAYIFCLTYEKLPDRFIFNYLKLKQDYTLKFITEIMNKNQISKNKFRNPIGNEIPSLTNEVKYWIGSIEY
Protein: Alpha-monoglucosyldiacylglycerol synthase (Alpha-MGS) (MGlcDAG synthase) (EC 2.4.1.337) (1,2-Diacylglycerol 3-glucosyltransferase) (UDP-glucose:1,2-diacylglycerol 3-alpha-D-glucosyltransferase) (Q93P60)
Organism: Acholeplasma laidlawii
Function: Glucosyltransferase involved in the biosynthesis of the non-bilayer-prone membrane lipid alpha-monoglucosyldiacylglycerol. This is a major component for maintaining a certain anionic lipid surface charge density, for balancing the bilayer to non-bilayer phase equilibria and for keeping a constant lipid bilayer spontaneous curvature (curvature packing stress). Catalyzes the transfer of a glucosyl residue from UDP-Glc to diacylglycerol (DAG) acceptor to form the corresponding alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol). It can only use UDP-Glc as sugar donor and DAG is the preferred substrate.
Subcellular location: Cell membrane {ECO:0000305|PubMed:11294844, ECO:0000305|PubMed:12911309}; Peripheral membrane protein {ECO:0000305|PubMed:11294844, ECO:0000305|PubMed:12911309}; Cytoplasmic side {ECO:0000305|PubMed:11294844, ECO:0000305|PubMed:12911309}. Note=The enzyme binds the membrane surface via electrostatic association with anionic lipids and is accompanied by hydrophobic interactions and by a conformational change induced by nonbilayer-prone lipids. The enzyme is supposed to be located on the cytosolic side of the membrane.
Interaction partners:
Sequence:
MRIGIFSEAYLPLISGVVTSVVNLKEGLEALGHEVYVITPIPSKDKFENDPSVIRIPGWVIPRKSLKGFRLVLFVKRYVRKMRKLKLDVVHIHTEFSMGKLGLAVAKKERIPSVYTLHTSYQDYTHYVSKLLTRFAPNAAKKLAGKINNQYTKNCHMTIVPTKKIYDKMIRLKHDGEFTIIPSGINLKPFYKSSYTSEQVQALKDKLGIRNDEFVAILVARIAKEKSIGDLVEAFVEFYKSYPNSRFIIIGDGPDKPVLDKLIDSKKASKYINTLGFVKNAEVGLYYQIADVFLNASTTETQGLTYVEALAASLPIIVRYDDVFDAFVEDGKNGIFFNKNEELVKHLIHIRQNPEILGTLSKNAEISTKPYAKEVYAKSCETLYLDLIDKNNKKLNKK
Protein: Lividin-1 (Q2UXR4)
Organism: Odorrana livida (Green mountain frog) (Polypedates lividus)
Function: Antimicrobial peptide.
Subcellular location: Secreted {ECO:0000255, ECO:0000269|PubMed:16713657}.
Interaction partners:
Sequence:
MFTLKKSLLLLFFLGTINLSLCQEERNADEEERRDERNVEVEKRILPFVAGVAAEMMQHVYCAASKKC
Protein: Catalase-A (EC 1.11.1.6) (O77229)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Subcellular location: Peroxisome matrix {ECO:0000250|UniProtKB:P04040}.
Interaction partners:
- 2-Hydroxyacid oxidase
- Catalase-B
- 3-hydroxyanthranilate 3,4-dioxygenase
- Kynureninase
- Glutathione reductase
- Superoxide dismutase 5
- Superoxide dismutase 1
- Glutathione synthetase
- Extracellular superoxide dismutase 2
- Senescence marker protein-30 family protein
Sequence:
MSAPVLTTSSGSPIDNNLNSMTAGVNGPILIQDFTLIDKLAHFDRERIPERVVHAKGAGAHGYFEVPSSDVPKWCKAKFLNKVGKRTPIFTRFSTVGGEKGSSDSERDPRGFAVKFYTEEGNFDMVGNNTPVFFIRDPSKFPDFIHTQKRNPQTNCKDPNMFWDFLGQTPESTHQVSILFSDRGTPKSYRHMHGFSSHTLKFVNAQGKPYWVKLHFTSETGIQNYTAEEAAKMSMNDPDSATRDLFETIAKGGEPAWKVSIQLMEFEDALKYRFNPFDVTKIWSHKDYPLIQIGRMVLNRNPENYFAEVEQAAFSPSHMVPGIEPSPDKMLQGRLFSYPDTHRHRLGVNYQQIPVNCPFAVKGGVKNYQRDGFMAVNGNGGKGPNYQPNSFGGPEPHPEFAQHKFDVSGFAARQPYNHPNDDFVQPGDLYRLMSEDAKSRFVSNLVGHMSGVTIKEIQVRAVSNFYKADKDLGARLCKGLGIDVNDVIKFAARSNL
Protein: Protein kinase, putative (EC 2.7.1.-) (Q382U0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein kinase, putative
Sequence:
MDSISSGLTHRAGLQQYPSGLVNVHVNNNPKINNGACSNMTPRESTNSARRSGSKRDRETADTADDGRNKNNQSITGTTATTTSTAKHSEMQPPPKKKKVTYALPNQSREEGHFYVVLGEDIDASTGRFKILSLLGEGTFGKVVEAWDRKRKEYCAVKIVRNVPKYTRDAKIEIQFMERVRLSDVEDRFPLMKIQRYFQNETGHMCIVMPKYGPCLLDWIMKHGPFNHRHLAQIIFQVGAALDYFHTELHLMHTDLKPENILMESGDTSVDPMTHRALPPEPCRVRICDLGGCCDERHSRTAIVSTRHYRSPEVVLSLGWMYSTDLWSMGCIIYELYTGKLLYDTHDNLEHLHLMEKTLGRLPADWSVRCGTQEARDLFTAAGTLQPCKDPKHIARIARARPVREVITEPLLCDLILNLLHYDRQRRLNARQMMSHAYVHKYFPECRQHPNHVDNRSKLPPTPVM
Protein: PID domain-containing protein (Q8I4H0)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAQKSDISVETANATSGKPNPPSPKSRLAMLKRTKKASNASSDPFRFQNNGISYKGKLIGEQDVDKARGDAMCAEAMRTAKSIIKAAGAHKTRITLQINIDGIKVLDEKSGAVLHNFPVSRISFIARDSSDARAFGLVYGEPGGKYKFYGIKTAQAADQAVLAIRDMFQVVFEMKKKQIEQVKQQQIQDGGAEISSKKEGGVAVADLLDLESELQQIERGVQQLSTVPTNCDAFGASPFGDPFVDSFNSTATSNGTANMSGTQVPFGGLQLPQVQQMQMPMVQIPQQSHQNWPTSGAGSFDAWGQQQQQQQMHHAHSTPAFGTNGFSDTNPFASAFNTQAPPPPLPTVAPTQYRDPFSVHSSAIPNSNIDWTGTGTTKENMAPSTNIQQQQSSLHHASTFANFGDNKAETWSEKKVTSLEEAFTKLVDMDALVGGQGIKETKKNPFEHILNPPKASLNSMSTTCSAAQMAATQQHTTSSHADPFGDDFFR
Protein: Reactive oxygen species modulator 1 (ROS modulator 1) (Epididymis tissue protein Li 175) (Glyrichin) (Mitochondrial targeting GxxxG motif protein) (MTGM) (Protein MGR2 homolog) (P60602)
Organism: Homo sapiens (Human)
Function: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}; Single-pass membrane protein {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim17-A
- Mitochondrial import inner membrane translocase subunit Tim21
- Mitochondrial import inner membrane translocase subunit Tim10
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import inner membrane translocase subunit Tim23
- Mitochondrial import inner membrane translocase subunit Tim17-B
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit TIM44
- NADH dehydrogenase 1 beta subcomplex subunit 7
Sequence:
MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC
Protein: Y' element ATP-dependent helicase YFL066C (EC 3.6.4.12) (P43538)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Interaction partners:
- Uncharacterized protein YFL065C
- Uncharacterized membrane protein YFL067W
- Uncharacterized protein YFL064C
- UPF0479 membrane protein YFL068W
- Uncharacterized protein YHL049C
- Putative uncharacterized protein YAR070C
- Putative uncharacterized protein YAR069C
- Putative UPF0377 protein YHL045W
- Putative UPF0320 protein YFL063W
- Putative uncharacterized protein YHR217C
Sequence:
MADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLGRRGCLNVAPVRNFIEEGYDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMQVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCVC
Protein: E3 ubiquitin-protein ligase TRIM39 (EC 2.3.2.27) (RING finger protein 23) (RING-type E3 ubiquitin transferase TRIM39) (Testis-abundant finger protein) (Tripartite motif-containing protein 39) (Q9HCM9)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.
Subcellular location: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:19100260}. Mitochondrion {ECO:0000269|PubMed:19100260}. Nucleus {ECO:0000269|PubMed:23213251}. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. {ECO:0000269|PubMed:19100260, ECO:0000269|PubMed:23213251}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:23213251}. Note=Colocalizes with CDKN1A in the nucleus. {ECO:0000269|PubMed:23213251}.
Interaction partners:
- Gamma-butyrobetaine dioxygenase
- Ribonuclease P/MRP subunit p21
- Modulator of apoptosis 1
- Splicing factor Cactin
- Ubiquitin-conjugating enzyme E2 D1
- E3 ubiquitin-protein ligase TRIM17
- cGMP-dependent protein kinase 1
Sequence:
MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
Protein: Guanine nucleotide-binding protein-like NSN1 (Nucleolar GTP-binding protein NSN1) (DAR GTPase 4) (Protein nucleostemin-like 1) (Q9M8Z5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the differentiation of epidermal cells, probably via the regulation of the expression of meristem-related genes (e.g. CLV3, STM, KNAT1, CUC2 and AG) and of leaf polarity-related genes (e.g. YAB5, FIL, AS2, PHB and PHV). May play a role in regulating cellular proliferation (By similarity). Necessary for flower development, probably by preventing apical dominance through the down-regulation of AG expression. Required for embryogenesis, leaf and cotyledon development, as well as for leaf polarity establishment. Plays an important role in plant growth and senescence by modulating ribosome biogenesis in nucleolus. Possesses GTPAse activity in vitro. Possesses RNA binding activity in vitro. Associates with ribosomes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Nucleus, nucleolus {ECO:0000269|PubMed:22357616, ECO:0000269|PubMed:26163696}. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9}.
Interaction partners:
- Nuclear/nucleolar GTPase 2
- Pescadillo homolog
- Ribosome biogenesis protein BOP1 homolog
- Ribosome biogenesis protein WDR12 homolog
- Probable rRNA-processing protein EBP2 homolog
- Ribosome assembly factor mrt4
- AT5g04600/T32M21_200
- Ribosome production factor 2 homolog
- Nucleolar complex-associated protein 3
- Probable ribosome biogenesis protein RLP24
Sequence:
MVKRSKKSKSKRVTLKQKHKVLKKVKEHHKKKAKDAKKLGLHRKPRVEKDPGIPNDWPFKEQELKALEVRRARALEEIEQKKEARKERAKKRKLGLVDDEDTKTEGETIEDLPKVVNVRDNSERAFYKELVKVIELSDVILEVLDARDPLGTRCTDMERMVMQAGPNKHLVLLLNKIDLVPREAAEKWLMYLREEFPAVAFKCSTQEQRSNLGWKSSKASKPSNMLQTSDCLGADTLIKLLKNYSRSHELKKSITVGIIGLPNVGKSSLINSLKRAHVVNVGATPGLTRSLQEVHLDKNVKLLDCPGVVMLKSSGNDASIALRNCKRIEKLDDPVSPVKEILKLCPKDMLVTLYKIPSFEAVDDFLYKVATVRGKLKKGGLVDIDAAARIVLHDWNEGKIPYYTMPPKRDQGGHAESKIVTELAKDFNIDEVYSGESSFIGSLKTVNEFNPVIIPSNGPLNFDETMIEDESKTQTEEEAEHESDDDESMGGEEEEEAGKTKEKSETGRQNVKLYAAESMLNTKKQKAEKKKRKKAKKAGADEEDLMDGDYDFKVDYRKNKDGEDEEFQIDAKIPMAGLLPEE
Protein: Putative diacyglycerol O-acyltransferase Rv3740c (EC 2.3.1.20) (Putative triacylglycerol synthase Rv3740c) (P9WKA5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Upon expression in E.coli has a weak triacylglycerol synthase function, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Also functions weakly as a wax synthase, as it incorporates palmityl alcohol into wax esters in the presence of palmitoyl-CoA.
Interaction partners:
- Possible oxidoreductase
- Possible oxidoreductase
- Triacylglycerol lipase
- Diacylglycerol kinase
- Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1
- Uncharacterized oxidoreductase Rv1543
Sequence:
MSPIDALFLSAESREHPLHVGALQLFEPPAGAGRGFVRETYQAMLQCREIAPLFRKRPTSLHGALINLGWSTDADVDLGYHARRSALPAPGRVRELLELTSRLHSNLLDRHRPLWETHVIEGLRDGRFAIYSKMHHALVDGVSGLTLMRQPMTTDPIEGKLRTAWSPATQHTAIKRRRGRLQQLGGMLGSVAGLAPSTLRLARSALIEQQLTLPFGAPHTMLNVAVGGARRCAAQSWPLDRVKAVKDAAGVSLNDVVLAMCAGALREYLDDNDALPDTPLVAMVPVSLRTDRDSVGGNMVGAVLCNLATHLDDPADRLNAIHASMRGNKNVLSQLPRAQALAVSLLLLSPAALNTLPGLAKATPPPFNVCISNVPGAREPLYFNGARMVGNYPMSLVLDGQALNITLTSTADSLDFGVVGCRRSVPHVQRVLSHLETSLKELERAVGL
Protein: SUN domain-containing protein 2 (Protein unc-84 homolog B) (Sad1/unc-84 protein-like 2) (Q8BJS4)
Organism: Mus musculus (Mouse)
Function: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5.
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:19933576}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UH99}. Nucleus envelope {ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:19843581, ECO:0000269|PubMed:19874786, ECO:0000269|PubMed:19933576}. Endosome membrane {ECO:0000250|UniProtKB:Q9UH99}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UH99}. Note=Colocalizes with KASH5 at sites of telomere attachment in meiocytes. {ECO:0000269|PubMed:24586178}.
Interaction partners:
- Nesprin-1
- Nesprin-2
- Protein KASH5
- Prelamin-A/C
- SUN domain-containing protein 1
- Emerin
- Nesprin-4
- Nesprin-3
- Lamin-B1
- Transmembrane protein 201
Sequence:
MSRRSQRLTRYSQDDNDGGSSSSGASSVAGSQGTVFKDSPLRTLKRKSSNMKHLSPAPQLGPSSDSHTSYYSESVVRESYIGSPRAVSLARSALLDDHLHSEPYWSGDLRGRRRRGTGGSESSKANGLTAESKASEDFFGSSSGYSSEDDLAGYTDSDQHSSGSRLRSAASRAGSFVWTLVTFPGRLFGLLYWWIGTTWYRLTTAASLLDVFVLTRSRHFSLNLKSFLWFLLLLLLLTGLTYGAWHFYPLGLQTLQPAVVSWWAAKESRKQPEVWESRDASQHFQAEQRVLSRVHSLERRLEALAADFSSNWQKEAIRLERLELRQGAAGHGGGSSLSHEDALSLLEGLVSRREATLKEDLRRDTVAHIQEELATLRAEHHQDSEDLFKKIVQASQESEARVQQLKTEWKSMTQEAFQESSVKELGRLEAQLASLRQELAALTLKQNSVADEVGLLPQKIQAARADVESQFPDWIRQFLLGDRGARSGLLQRDEMHAQLQELENKILTKMAEMQGKSAREAAASLGQILQKEGIVGVTEEQVHRIVKQALQRYSEDRIGMVDYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGTFAYDQDGEPIQTFYFQASKMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH
Protein: WD repeat-containing protein 55 (Q9H6Y2)
Organism: Homo sapiens (Human)
Function: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Ribosome biogenesis protein WDR12
- Protein Red
- Pescadillo homolog
- Ribosome biogenesis protein BOP1
Sequence:
MDRTCEERPAEDGSDEEDPDSMEAPTRIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVVVDDYRRRKKKGGPLRALSSKTWSTDDFFAGLREEGEDSMAQEEKEETGDDSD