wanglab/gogpt-training-data huggingface dataset:
Protein: Fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2) (P10173)
Organism: Sus scrofa (Pig)
Function: Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable).
Subcellular location: [Isoform Mitochondrial]: Mitochondrion {ECO:0000250|UniProtKB:P07954}.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P07954}. Nucleus {ECO:0000250|UniProtKB:P07954}. Chromosome {ECO:0000250|UniProtKB:P07954}. Note=Translocates to the nucleus in response to DNA damage: localizes to DNA double-strand breaks (DSBs) following phosphorylation by PRKDC. {ECO:0000250|UniProtKB:P07954}.
Interaction partners:
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Malate dehydrogenase, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Malate dehydrogenase, cytoplasmic
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- NADP-dependent malic enzyme
- Malic enzyme
- Malic enzyme
- Citrate synthase, mitochondrial
Sequence:
MDRALRLLARSRCLSRVPASAPGPGPGSSPSGVSRLLLRPPNAARMASQNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPIPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHPNDHVNKSQSSNDTFPTAMHIAAAVEVHEALLPGLQKLHDALDAKSREFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAITRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEALTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDAAVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKATAVELGYLTAEQFDEWVKPKDMLGPK
Protein: Aspartyl aminopeptidase (EC 3.4.11.21) (F8WAN0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNGKARKEAVQTAAKELLKFVNRSPSPFHAVAECRNRLLQAGFSELKETEKWNIKPESKYFMTRNSSTIIAFAVGGQYVPGNGFSLIGAHTDSPCLRVKRRSRRSQVGFQQVGVETYGGGIWSTWFDRDLTLAGRVIVKCPTSGRLEQQLVHVERPILRIPHLAIHLQRNINENFGPNTEMHLVPILATAIQEELEKGTPEPGPLNAVDERHHSVLMSLLCAHLGLSPKDIVEMELCLADTQPAVLGGAYDEFIFAPRLDNLHSCFCALQALI
Protein: Interferon-alpha (D1M7B1)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAVPASPQHPRGYGILLLTLLLKALATTASACNHLRPQDATFSHDSLQLLRDMAPTLPQLCPQHNASCSFNDTILDTSNTRQADKTTHDILQHLFKILSSPSTPAHWNDSQRQSLLNRIHRYTQHLEQCLDSSDTRSRTRWPRNLHLAIKKHFSCLHTFLQDNDYSACAWEHVRLQARAWFLHIHNLTFITRT
Protein: Large ribosomal subunit protein uL13m (39S ribosomal protein L13, mitochondrial) (L13mt) (MRP-L13) (Q9BYD1)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Interaction partners:
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein uL22m
- Large ribosomal subunit protein mL41
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein uL24m
- Large ribosomal subunit protein bL20m
Sequence:
MSSFSRAPQQWATFARIWYLLDGKMQPPGKLAAMASIRLQGLHKPVYHALSDCGDHVVIMNTRHIAFSGNKWEQKVYSSHTGYPGGFRQVTAAQLHLRDPVAIVKLAIYGMLPKNLHRRTMMERLHLFPDEYIPEDILKNLVEELPQPRKIPKRLDEYTQEEIDAFPRLWTPPEDYRL
Protein: GH12052p (Q86NV5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
RLRGLLKIMPEVDELDMLKGFNGDKARLGNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSEQINNEINTLDGRIRRIARQIEQPATDVDIKEQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENERRQQQEQQATLRRKQREEQLARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLGSGEISNGFIRLEQDGASPDITPNGSLRRRRSRVLAEEDDLMEFLRSSTGPHHDGHNSRERKAAYGSLDRSWARRARSGSSSRKRPDLLNIDFGMDRERASSPAPLLQQQQQNVQERLQSPLASTAGTPTTAANTPTGSGSAIAQTPSNNEDAKPRISREWRQKIETWLQSNESDEKQNEEYRRKRRLVNANRRSLENETENERKLDPLPEEKILPSTTTATPTNTPTTTNPTNSTNRMDQESGKYQRVYADWKPSRTLEQTDVVANLQAIADAQPHDALRQHRRQRSQEQPSPIALQSIAEEDRRKSLIQKQGERDKSNERLQIYIRRSSSRELQPAKTEEHPLPPKSPKPQVSDDTFASLLSHHKTQNEMQGSSKDVDADNIETPPVSRRVIATPTTTVVTVSMTDKPKAATEEKINPAEQDAPGHFDRHALARRTRRYKRPTDYSSGNEEALTTSTAEAKTSPSKPEPPAPEKSKQKERTINKLEKVGRHISSINQEDVREAIRNLKSPTGTPERPWSPPRDITPSKLKLSASGHHELNDEGFEETQSLVSDTPSHGKGESTNSSCNEGVNETPARQRPMQKQKPTTTSISQMGSRLADRLQQARMKSSGSSGSAASKSQNQIPATQTATVKRSLSASRPLRMPNGQPLASAAPLRSASTVRRSPQEQQVLAGVERSSSRNSLRSSRSSINSGASTQTVVRRLPAVQRAGATVSVDSSPSKRPLAAQNLRPTQGRGVPASRSSSSGSSVGPSVILVRSKMSNTAPKSSIHGSTSFKENQSQSQPQSQSRMSAARSVVLVKNALNQQQQARMSANPSPQQRSTSSSRSVSSFMRPTASSATKRQK
Protein: Rab proteins geranylgeranyltransferase component A (Rab escort protein) (REP) (P32864)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta
- GTP-binding protein YPT1
- Geranylgeranyl transferase type-2 subunit alpha
- Ras-related protein SEC4
- GTP-binding protein YPT6
- Ypt/Rab-type GTPase YPT7
- Transcription factor SFP1
- Vacuolar protein sorting-associated protein 21
- GTP-binding protein YPT53
- GTP-binding protein YPT52
Sequence:
MLSPERRPSMAERRPSFFSFTQNPSPLVVPHLAGIEDPLPATTPDKVDVLIAGTGMVESVLAAALAWQGSNVLHIDKNDYYGDTSATLTVDQIKRWVNEVNEGSVSCYKNAKLYVSTLIGSGKYSSRDFGIDLSPKILFAKSDLLSILIKSRVHQYLEFQSLSNFHTYENDCFEKLTNTKQEIFTDQNLPLMTKRNLMKFIKFVLNWEAQTEIWQPYAERTMSDFLGEKFKLEKPQVFELIFSIGLCYDLNVKVPEALQRIRRYLTSFDVYGPFPALCSKYGGPGELSQGFCRSAAVGGATYKLNEKLVSFNPTTKVATFQDGSKVEVSEKVIISPTQAPKDSKHVPQQQYQVHRLTCIVENPCTEWFNEGESAAMVVFPPGSLKSGNKEVVQAFILGAGSEICPEGTIVWYLSTTEQGPRAEMDIDAALEAMEMALLRESSSGLENDEEIVQLTGNGHTIVNSVKLGQSFKEYVPRERLQFLFKLYYTQYTSTPPFGVVNSSFFDVNQDLEKKYIPGASDNGVIYTTMPSAEISYDEVVTAAKVLYEKIVGSDDDFFDLDFEDEDEIQASGVANAEQFENAIDDDDDVNMEGSGEFVGEMEI
Protein: Zinc finger protein GLIS2 homolog (Protein sugarbabe) (Q7K0S9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription factor which represses a set of lipase genes involved in fat catabolism.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MDIIQKSIFNSGPHSRGIYEPPLGYFTPYNTPPYIAAYSDSGSWLADHHQHHQQQHQQHQQQMQHIRFPTPPITPPRPIAGYGYRQRTQSVIMKARGQQDELCRSPVEFPDDSKSCSSSSECGTASDFVCNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHLCEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKTFKHSIHLIASQPLTLPSVPCLLEASSESAFTCLPAASSVESTSSSSSARYYDDSNNEPSDYSLKPKQDAEFSPSYWLGDRQHSYLHSEDFFVKMDVESPLDLRIHRI
Protein: G2/M-phase specific E3 ubiquitin protein ligase (F5GX24)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSGIWQRGKEEEGVYGFLIEDIRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSYHFPCGLQRECIFQFTGNFASFCWDHRPVQIITSNNYRESLPCTICLEFIEPIPSYNILRSPCCKNAWFHRDCLQVQAINAGVFFFRCTICNNSDIFQKEMLRMGIHIPEKDASWELEENAYQELLQHYERCDVRRCRCKEGRDYNAPDSKWEIKRCQCCGSSGTHLACSSLRSWEQNWECLECRGIIYNSGEFQKAKKHVLPNSNNVGITDCLLEESSPKLPRQSPGSQSKDLLRQGSKFRRNVSTLLIELGFQIKKKTKRLYINKANIWNSALDAFRNRNFNPSYAIEVAYVIENDNFGSEHPGSKQEFLSLLMQHLENSSLFEGSLSKNLSLNSQALKENLYYEAGKMLAISLVHGGPSPGFFSKTLFNCLVYGPENTQPILDDVSDFDVAQIIIRINTATTVADLKSIINECYNYLELIGCLRLITTLSDKYMLVKDILGYHVIQRVHTPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSELFTVHTLPDVKALGFWNSYLQAVEDGKSTTTMEDILIFATGCSSIPPAGFKPTPSIECLHVDFPVGNKCNNCLAIPITNTYKEFQENMDFTIRNTLRLEKEESSHYIGH
Protein: Divalent cation/proton antiporter GDT1 (GCR1-dependent translation factor 1) (P38301)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in ribosome biogenesis. Has also been proposed to play a role in calcium homeostasis.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:23569283}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with Gos1p in the medial-Golgi stacks. {ECO:0000269|PubMed:23569283}.
Interaction partners:
- Calcium-transporting ATPase 1
- Vacuolar calcium ion transporter
- Solute carrier RCH1
- Calcium-transporting ATPase 2
- Uncharacterized protein YIL067C
- Protein DML1
- Protein UIP5
Sequence:
MGNMIKKASLIALLPLFTAAAAAATDAETSMESGSSSHLKSFLMSVSMIGLSEIGDKTFLIAALMAMRHKRVLVFSAAATSLAIMTILSGVVGHSAVAFLSERYTAFFAGILFLVFGYKLTMEGLEMSKDAGVEEEMAEVEEEIAIKDMNQDMDDVEKGGDTAYDKQLKNASIGKKIVHRIRELASFMFSPVWVQIFLMVFLGELGDRSQISIIAMATDSDYWYVIAGAVIGHAICSGLAVVGGKLLATRISIRTITLASSLLFFIFALMYIYQAFTTQD
Protein: Uncharacterized protein, isoform E (A0A0B4LEX9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- MD-2-related lipid-recognition domain-containing protein
- Uncharacterized protein, isoform A
- Serpin 28Da
Sequence:
MIAISDNSLGQRLKRLQLAFLLIALWDSTRALTVDNQLVSARNDCFERIALEAMLPFEKTFRTEDTNSLKMCKEKCLQAGEKCQAISFGVHRRGNGTCQLSSEQYGSGGGGRPGGVIFDPDFDLYTRKTNCFDLSDNSIAAGPQPVPGPSPISPGPTPLDLPNRPLDVGNTPVLVVNPTPHTSGSPPPPLGPSLPPPGVGDRLYFSHDLYPLYKYPTLYESNYPSPNEEAYIPGGYAANAPEVDERYRPHYGPIEPAEDEGIRPTPHSPPRPIFGLGYGNGYSYGSPERYTPPTGRPSSGSSEERPSYAARPPRPTADRPEYPPGPPRPTADRPEYPPRPYEGSTPPSYGPRPSPSYDPDREPRPDYTNRPDPPSLSPQVGYGMNGPSARPPPTSYDGPPPPRDEYVRRNGSAMRPGDGYGGYDDDKTIATYFNPDDYMQGNNNRPMPSDRDRDRNRDRLGYPMDEMKACFRRVLAGKRIAPHFVRRSISCERVEECMRECGRERRFMCEGFNYRLDPSGHGQGDCELVEMPLAQMDLYSSPDRRDANLLRHPDYDYYERDRNAPSSCRRSACQDCSKGPVSSQPVYFKPSGGAGGYGDRDRDRDRDRDHYRPHSNTAVDHYRGPSGPPGSSSYEHRPPYSSEFHGSHSSSSSASSYEFSSHGSGSSSGSSSGYFGHTPPSSYGGDHPYVDRHDSPHYRPGRPDRWETLPSSSGYDSSAYRPPRPETDRIDKYRPPYRPGSDYSPYRPPSRPSHNYLDRDGAGPPGPPGSNKKPNKFVPYLIGGEDNWGHYGGSYGGSSKHSSSSSSSYWGLTESQRRKDQHDFNYFQLGAPHRESNSVLSYPGSGYEDDYPRRRNDYRQQWTRRAGPDECSAKTSEGFRLHKTAVRHAYNVPTLTECERLCSDPRPSFVCHTFSYRYNQAGRDNCMLCDRPINMLDYYVDIEPDRDYDIYSMADDMDVCRQPPPRRHDTAGPSTAISDPRNAQCFFRAIDATRFFKSIVRDSLTVRSVGECEMECIRSTKFTCRAFAFRYGQQRHAGVIDNCQLSDWPVRDMDKERHLILDAAFDIFERASYGHGCEIQPIVDEKHKKLCYLGYGSPARLLPPAIKKVISVPSEIACKKECIRFRETTPFKCFAFSYGSHASSFNCELSDLDQTELKQDVHYAHTKDRDFWLFAWNPFDWTCRDKVNTIGGSRVNNDRRMDIFREPGDVAWRHYTVSGKPCRRSSPCAKNLITGFYSCETDASEVGSWDYCCKADHPCGYSKGFDYPWCFVGDESDQWRKCSDRYFPGKNGTQPTHSHLGLPSAKEKQKHPHPHHSQPATAASSEYSQHPPRPGGLQSLSDFAAARLWPVTYLYSEGPPNATEFSNFVDCNKESC
Protein: Isoamylase 1, chloroplastic (OsISA1) (EC 3.2.1.68) (Protein SUGARY-1) (D0TZF0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Starch-debranching enzyme involved in amylopectin biosynthesis in endosperm. Functions by removing excess branches or improper branches that interfere with the formation of double helices of the cluster chains of amylopectin and crystallization of starch. Works as ISA1 homooligomer or together with ISA2 as heterooligomer. The heterooligomer ISA1 and ISA2 possesses higher affinity than the ISA1 homooligomer for various branched polyglucans in vitro, but no marked differences exist in chain preferences for debranching of amylopectin and phytoglycogen between these forms.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Isoamylase 2, chloroplastic
- Alpha-1,4 glucan phosphorylase
- Alpha-1,4 glucan phosphorylase
- 4-alpha-glucanotransferase DPE2
- Soluble starch synthase 3a, chloroplastic/amyloplastic
- 1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic
- ornithine carbamoyltransferase
- 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic
- Os04g0409200 protein
- 1,4-alpha-glucan branching enzyme
Sequence:
MASLPHCLSARPLVVAAAPGRPGPGPGPWLRGGARRRNAAFSAGNAGRRVGLRRSVASAVEVGVGEDEEEGVEEEEEEVEAVVMPERYALGGACRVLAGMPAPLGATALDGGVNFAVYSAGASAASLCLFTPDDLEADEVTEEVPLDPLFNRTGNVWHVFIEGELHNMLYGYRFDGMFAPHCGQYFDVSNVVVDPYAKAVISRGEYGVPGPGGDCWPQMAGMIPLPYSTFDWQGDLPLRYPQKDLVIYEMHLRGFTKHSSSNVEHPGTYIGAISKLDYLKELGVNCVELMPCHEFNELEYFSCSSKMNFWGYSTINFFSPMIRYSSGGIRNCGRDAINEFKTFVREAHKRGIEVIMDVVFNHTAEGNEKGPILSFRGIDNSTYYMLAPKGEFYNYSGCGNTFNCNHPVVREFIVDCLRYWVTEMHVDGFRFDLASIMTRGCSLWDPVNVYGSPVEGDMTTTGTPLATPPLIDMISNDPILGDVKLIAEAWDAGGLYQVGQFPHWKIWSEWNGKYRDIVRQFIKGTDGFAGGFAECLCGSPHLYQAGGRKPWHSINFVCAHDGFTLADLVTYNKKYNSSNGEDNRDGENHNLSWNCGEEGEFAGLSVKRLRKRQMRNFFVSLMVSQGVPMFYMGDEYGHTKGGNNNTYCHDHYVNYFRWDKKEESSDLQRFCSLMTKFRKQCESLGLADFPTAQRLHWHGHQPGKPDWSETSRFVAFSTKDETKGEIYVAFNASHLPAVVGLPERPGYRWEPLVDTGKPAPYDFLTDDLPDRAHAVHLFSHFLNSNLYPMLSYSSIILELQPDD
Protein: Transcription factor 15 (TCF-15) (Class A basic helix-loop-helix protein 40) (bHLHa40) (Paraxis) (Protein bHLH-EC2) (Q12870)
Organism: Homo sapiens (Human)
Function: Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q60756, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Homeobox protein MOX-2
- Homeobox protein Mohawk
- Forkhead box protein C2
- Cadherin-17
Sequence:
MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGAGPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETVRLASSYIAHLANVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSCLKVRGVAPLRGPRR
Protein: Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) (P49584)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P19836}. Membrane {ECO:0000250|UniProtKB:P19836}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19836}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49585}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19836}. Nucleus {ECO:0000269|PubMed:8185307}. Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form. {ECO:0000250|UniProtKB:P19836}.
Interaction partners:
Sequence:
MDAQSSAKVNSRKRRKEASSPNGATEEDGIPSKVQHCSVGLRQPAPFSDEIEVDFSKPYVRVTMEEACRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYPIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEERSIDLIQTWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPRQSPSSSPTHERSPSPSFRWPFSGKTSPSSSPASLSRHKAVTCDISEDEED
Protein: mRNA-binding protein PUF3 (Pumilio homology domain family member 3) (Q07807)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of COX17 by binding to the 3'-UTR of COX17 mRNA. Promotes decay of COX17 mRNA by enhancing its rate of deadenylation and subsequent turnover. Predominantly binds to mRNAs encoding mitochondrial proteins and localizes them to the vicinity of mitochondria for translation. Regulates mitochondrial biogenesis, motility and morphology.
Subcellular location: Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Localizes to multiple discrete foci in the cytoplasm.
Interaction partners:
- Cytochrome c oxidase copper chaperone
- Poly
- ATP-dependent RNA helicase DHH1
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- Mitochondrial import receptor subunit TOM20
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
- Small ribosomal subunit protein mS43
- Thiosulfate sulfurtransferase RDL2, mitochondrial
- Polyadenylate-binding protein, cytoplasmic and nuclear
Sequence:
MEMNMDMDMDMELASIVSSLSALSHSNNNGGQAAAAGIVNGGAAGSQQIGGFRRSSFTTANEVDSEILLLHGSSESSPIFKKTALSVGTAPPFSTNSKKFFGNGGNYYQYRSTDTASLSSASYNNYHTHHTAANLGKNNKVNHLLGQYSASIAGPVYYNGNDNNNSGGEGFFEKFGKSLIDGTRELESQDRPDAVNTQSQFISKSVSNASLDTQNTFEQNVESDKNFNKLNRNTTNSGSLYHSSSNSGSSASLESENAHYPKRNIWNVANTPVFRPSNNPAAVGATNVALPNQQDGPANNNFPPYMNGFPPNQFHQGPHYQNFPNYLIGSPSNFISQMISVQIPANEDTEDSNGKKKKKANRPSSVSSPSSPPNNSPFPFAYPNPMMFMPPPPLSAPQQQQQQQQQQQQEDQQQQQQQENPYIYYPTPNPIPVKMPKDEKTFKKRNNKNHPANNSNNANKQANPYLENSIPTKNTSKKNASSKSNESTANNHKSHSHSHPHSQSLQQQQQTYHRSPLLEQLRNSSSDKNSNSNMSLKDIFGHSLEFCKDQHGSRFIQRELATSPASEKEVIFNEIRDDAIELSNDVFGNYVIQKFFEFGSKIQKNTLVDQFKGNMKQLSLQMYACRVIQKALEYIDSNQRIELVLELSDSVLQMIKDQNGNHVIQKAIETIPIEKLPFILSSLTGHIYHLSTHSYGCRVIQRLLEFGSSEDQESILNELKDFIPYLIQDQYGNYVIQYVLQQDQFTNKEMVDIKQEIIETVANNVVEYSKHKFASNVVEKSILYGSKNQKDLIISKILPRDKNHALNLEDDSPMILMIKDQFANYVIQKLVNVSEGEGKKLIVIAIRAYLDKLNKSNSLGNRHLASVEKLAALVENAEV
Protein: Putative beta-neurotoxin RjAa12f (E7CLP2)
Organism: Rhopalurus junceus (Caribbean blue scorpion)
Function: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is lethal to insects (A.domestica). It is not toxic to mice and does not affect mammal F11 sodium channels.
Subcellular location: Secreted {ECO:0000269|PubMed:21605585}.
Interaction partners:
Sequence:
MKILIFIIASFMLIGVECKEGYPMGRDGCKISCVINNNFCKVECQAKWRQSDGYCYFWGLSCYCTNLPEDAQVWDSSTNKCGG
Protein: Syntaxin-4 (Q7KVY7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones.
Subcellular location: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Interaction partners:
- Vesicle-associated membrane protein 7
- Alpha-soluble NSF attachment protein
- Synaptosomal-associated protein
- LD03592p
- Synaptosomal-associated protein 25
- Synaptobrevin
- Tomosyn, isoform C
- Secretory 22, isoform B
- Neuronal synaptobrevin, isoform J
- Syntaxin 16
Sequence:
MGKDRLPELLQRSLSTNSSNSSSNGSLLLNVYSGTTEFIIGNTGGNNNSYSVVSQNSHSCSNNNSSTEPKDRSSSKMTQYGSNVDDILNPYTEIRQQLAQIAANLETMNRMAQTVNLRTFNENEMDELHNKNLRLGNQLMTRFNDFKANLPAENDYSLEARMKRTLFYGLHQTFINLWHKNELFLQNYETKVKKNLRLHTKIINSEASEQEIELLIENKTTKLFVDNFLQETEKERQTLREMMDRFNELRRLEKSIEEVHALFMRIQTLVMEQSEVIQRVEFHAQQATLHVDKGADELDQAEQHQKKARKKKIMLIVILAAVLLVLLLVGIYL
Protein: Small ribosomal subunit protein uS19 (40S ribosomal protein S15) (A1ZAH8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQQVDENLKKKRTFKKFTYRGVDLDQLLDMPNNQLVELMHSRARRRFSRGLKRKPMALIKKLRKAKKEAPPNEKPEIVKTHLRNMIIVPEMTGSIIGVYNGKDFGQVEVKPEMIGHYLGEFALTYKPVKHGRPGIGATHSSRFIPLK
Protein: Cystatin-S (Cystatin-4) (Cystatin-SA-III) (Salivary acidic protein 1) (P01036)
Organism: Homo sapiens (Human)
Function: This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.
Subcellular location: Secreted {ECO:0000269|PubMed:20189825}.
Interaction partners:
- Cystatin-SN
- Lipocalin-1
- Cathepsin S
- Mucin-5B
- Cystatin-SA
- Cathepsin B
- Statherin
- demerged
- Histatin-1
- Mucin-7
Sequence:
MARPLCTLLLLMATLAGALASSSKEENRIIPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWEDRMSLVNSRCQEA
Protein: bZIP transcription factor 27 (AtbZIP27) (Protein FD PARALOG) (Q7PCC6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor required for the transition to flowering promoted by FT.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Protein FLOWERING LOCUS T
- Protein TWIN SISTER of FT
- Basic-leucine zipper
- Choline transporter-like protein
- Basic-leucine zipper
Sequence:
MLSSAKHNKINNHSAFSISSSSSSLSTSSSLGHNKSQVTMEEVWKEINLGSLHYHRQLNIGHEPMLKNQNPNNSIFQDFLNMPLNQPPPPPPPPSSSTIVTALYGSLPLPPPATVLSLNSGVGFEFLDTTENLLASNPRSFEESAKFGCLGKKRGQDSDDTRGDRRYKRMIKNRESAARSRARKQAYTNELELEIAHLQTENARLKIQQEQLKIAEATQNQVKKTLQRSSTAPF
Protein: DNA polymerase (EC 2.7.7.7) (Q5JQP4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU366014}.
Interaction partners:
Sequence:
MHHQKYLQRFLGGKREKKQKEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
Protein: Tsukubadiene synthase (TdS) (EC 4.2.3.159) (I2N045)
Organism: Streptomyces tsukubensis (strain DSM 42081 / NBRC 108919 / NRRL 18488 / 9993)
Function: Catalyzes the formation of the 5-9-5 ring skeleton (3S,6S,11R,14S)-tsukubadiene from geranylgeranyl diphosphate (GGPP) via a 1,11-cyclization and a 10Re,14Re-cyclization.
Interaction partners:
Sequence:
MIEVPPFWCPLPIAIHPAADQAEKDARAWAERYGVRLRIADQVQPGRLGAYWAPHGTYEGMLAVGCWNFWAFAFDDHLDEPLPLDVPVTTSLVQQAVDIPSPPITDDPWAAGAQAVFNMFRDLATPTQVRYCADNHRRWLHGACWRHSNHVNRRLPPLAEYIPLRMQDAAAQATCLIAVLIGSDISVPEQEMDSPRVRALLETASWTATIDSDLHSFQLEDTQRPVSQHIVSVLMHERGIGVDEALRQSVALRDRFMTRFLHLQQECARTGSSELARFAHTLGYVISGYLQWAVDTSRYGQTEATFSFTDTPRDDTPEPPPGIPSVEWLWTL
Protein: FERM domain-containing protein 5 (Q7Z6J6)
Organism: Homo sapiens (Human)
Function: May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:22846708}.
Interaction partners:
Sequence:
MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSNERVAVIADEAYSPADSVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEVEALGGELRALCQGHSGPEEEQVNKFVLSVLRLLLVTMGLLFVLLLLLIILTESDLDIAFFRDIRQTPEFEQFHYQYFCPLRRWFACKIRSVVSLLIDT
Protein: SECIS binding protein 2 (Q8BYU9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MASERPREPDGEDSIKLSADVKPFVPKFAGLNVAWSESSETRVFPGCAATYYPFVQEPPAAEQKMYPEDMAFGAPTFPAQYVSSEIALHPFAYPTYTLESAQSVCSVPTLQYDYSQARCHPGFRTAKPRHEHVCPPPQEAKGVFKKKPSDERRACEEQKSSSRRADNAVPCEARPARGSSHLSSRTESSLKSDGYHKRPDRKSRILAKSASTSKPEFEFSRLDFPELQSPKNSNMPETQKPPRWGPLGPAASNMPLLGDVGKPVADMVEGKMVKSDHTDGAVTSNATTSSPSCTQELSWTPMGYIVRQTVSSDSAAATENVTSMINLKKTTSSADAKNVSVTSEALSSNPSYNREKRVYPAPKVCVKDPRSRMGSGCSGKNCNSALGRLIQEDCKSKAILGHIVNPCLKIKAIR
Protein: Tyrosine-protein phosphatase domain-containing protein (Q382S4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQLKERLQQWRERGLQGADVDPPVQRPRSFRPSCIVPRLYLGAAKDVQDVRTLRSRLLPDKLLMVVSTCDPSDPPRMELRQIAPTKGTAYTVKRLAVCSWEELEKRVVTSSFCCRLPRNEVMVATAEWLKEVLKTKSLPPVSLEECRDVQKGETDGKVSEVFEEGLYLKLCLPWKDESNFTVRPYFAVATALIHATMDGIQGAVVCYCMAGKSRSATLTCALLLYCCYDNVGRPKDEEECSAYKAVQAVVEFVREVRLCVSPNEGFIEQLRDYASDLLAV