wanglab/gogpt-training-data huggingface dataset:
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa homolog) (Protein HRPAP20) (Q9NQR8)
Organism: Rattus norvegicus (Rat)
Function: May be involved in cell proliferation and survival of hormone-dependent tumor cells. Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity).
Subcellular location: Mitochondrion {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:Q9P032}; Lipid-anchor {ECO:0000250|UniProtKB:Q9P032}.
Interaction partners:
- NADH dehydrogenase Fe-S protein 7, isoform CRA_d
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH:ubiquinone oxidoreductase complex assembly factor 2
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex assembly factor 3
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- Complex I intermediate-associated protein 30, mitochondrial
Sequence:
MGARMTRAFRNFNVEKRAEQEISKRKPSMAPKHPSTRSLLQEHLSQYPEIEEEVSRKDNKLLSLLRDVYVNSKDPVPSLPVKAIEPQQQPKEFRLPIGDQFDKNIKDIPKGKITVVEALTLLNNHKLSPETWTAEKIAQEYHLELEDVNSLLKYFVTFEVKIVPPEDRKAIQSK
Protein: Ceramide synthase subunit LIP1 (LAG1/LAC1-interacting protein 1) (Q03579)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ceramide synthase complex required for synthesis of ceramides.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15692566}; Single-pass type II membrane protein {ECO:0000269|PubMed:15692566}.
Interaction partners:
- Ceramide synthase LAG1
- Ceramide synthase LAC1
- Sphingolipid C4-hydroxylase SUR2
- Serine palmitoyltransferase 2
- Serine palmitoyltransferase-regulating protein TSC3
- Serine palmitoyltransferase 1
Sequence:
MSQPTPIITTKSAAKPKPKIFNLFRVCFISLLLIAAVEYFKYGTRINYEWFHCTPIKEPQSGSVIKLWARGGPSCDKRGEYKTIVKRITRDYEPNDEHLSFCIIENDNVPPVHYPIHEDKGEPGYVAYVGYDTDSELVQELCADSTIYHM
Protein: Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (IgE-binding protein) (L-34 galactoside-binding lectin) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) (P16110)
Organism: Mus musculus (Mouse)
Function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P17931}. Nucleus {ECO:0000250|UniProtKB:P17931}. Secreted {ECO:0000250|UniProtKB:P17931}. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P17931}.
Interaction partners:
- Lymphocyte activation gene 3 protein
- Mucin-1
- Low affinity immunoglobulin gamma Fc region receptor II
- Receptor-type tyrosine-protein phosphatase C
- Tripartite motif-containing protein 16
- Fibronectin
- Elastin
- Integrin beta-1
- Platelet glycoprotein VI
- Toll-like receptor 2
Sequence:
MADSFSLNDALAGSGNPNPQGYPGAWGNQPGAGGYPGAAYPGAYPGQAPPGAYPGQAPPGAYPGQAPPSAYPGPTAPGAYPGPTAPGAYPGQPAPGAFPGQPGAPGAYPQCSGGYPAAGPYGVPAGPLTVPYDLPLPGGVMPRMLITIMGTVKPNANRIVLDFRRGNDVAFHFNPRFNENNRRVIVCNTKQDNNWGKEERQSAFPFESGKPFKIQVLVEADHFKVAVNDAHLLQYNHRMKNLREISQLGISGDITLTSANHAMI
Protein: Probable alpha/beta-glucosidase agdC (EC 3.2.1.20) (EC 3.2.1.21) (Q1HFV4)
Organism: Emericella nidulans (Aspergillus nidulans)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLGFLLFLPLVGAAVIGPRANSQICPGYKASHAKHNSHTFTADLTLAGKPCDTYGTDLKDLKLLVEYQTDERLHVMIYDANEQVYQVPESVLPRVGNGNGTEKDSALKFDYVEEPFSFTVSRNGDVLFDTSASNLIFQSQYLNLRTWLPNDPHLYGLGEHTDSLRLETNNYTRTLWNRDSYGVPSHSNLYGAHPVYYDHRGSAGTHGVFLANSNGMDIKINKTLDGKQYLEYNILGGVLDFYFFTGSTPKEASTQYAKVVGLPAMQSYWTFGFHQCKYGYRDVYEVAEVVYNYSQAGIPLETMWTDIDYMELRRVFTLDPERFPLGKMRELVDYLHDHNQHYIVMVDPAVSTSDNPGYRRGVEQDIFLKTQNGSLYKGAVWPGVTVYPDWFHPAIQDYWNGEFNKFFDPETGIDIDGLWIDMNEAANMCTFPCTDPERYSIENDLPPAPPAVRPSNPRPLPGFPDDFQPGSSKRLSKRAHGDKLGLPGRNLLSPPYSIKNAAGALSQNTIQTNIGHAGGYVEYDTHNLYGTMMSSASRIAMQQRRPDVRPLIITRSTYAGAGAHVGHWLGDNLSTWKLYRASIAQVLAFASMFQIPMVGADVCGFGSNTTEELCARWASLGAFYTFYRNHNEIGNIPQEYYYWESVTESATKAINIRYQLLDYVYTAFHRQSKTGEPFLQPLFYLYPEDKNTFAIDLQFFYGDAILISPVTEKNSTSVNAYFPKDIFYDWYTGAVIQGQGANIILSNINITHIPIHIRGGNIVPIRSSGAMTTTELRKKGFQLIIASGIDGTASGSLYLDDGDSLEQTDTANIEFEYRSGVLYIKGQFIHDVPVKIESVILLGQTTTAGAGRHNQKQVIETNLELTAPTRVKLA
Protein: Small ribosomal subunit protein uS12cz/uS12cy (30S ribosomal protein S12, chloroplastic) (P0C460)
Organism: Oryza sativa (Rice)
Function: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits (By similarity).
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MPTVKQLIRNARQPIRNARKSAALKGCPQRRGTCARVYTINPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYRIIRGALDAVAVKNRQQGRSKYGVKKPKK
Protein: Calbindin (Calbindin D28) (D-28K) (Vitamin D-dependent calcium-binding protein, avian-type) (P04354)
Organism: Gallus gallus (Chicken)
Function: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Interaction partners:
- Parvalbumin, muscle
- Somatostatin
- 45 kDa calcium-binding protein
- Glutamate decarboxylase 1
- Tyrosine 3-monooxygenase
- Glial fibrillary acidic protein
- Pro-neuropeptide Y
- Paired box protein Pax-6
- Visual system homeobox 2
- Proenkephalin
Sequence:
MTAETHLQGVEISAAQFFEIWHHYDSDGNGYMDGKELQNFIQELQQARKKAGLDLTPEMKAFVDQYGKATDGKIGIVELAQVLPTEENFLLFFRCQQLKSSEDFMQTWRKYDSDHSGFIDSEELKSFLKDLLQKANKQIEDSKLTEYTEIMLRMFDANNDGKLELTELARLLPVQENFLIKFQGVKMCAKEFNKAFEMYDQDGNGYIDENELDALLKDLCEKNKKELDINNLATYKKSIMALSDGGKLYRAELALILCAEEN
Protein: Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) (P13863)
Organism: Gallus gallus (Chicken)
Function: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. May play a role in regulating the amplitude of the cyclic expression of circadian clock genes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P06493}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P06493}.
Interaction partners:
- G2/mitotic-specific cyclin-B2
- Cyclin-A2
- Cyclin A1
- BUB1 N-terminal domain-containing protein.
- BUB1 mitotic checkpoint serine/threonine kinase
- Wee1-like protein kinase
- Cell division cycle 25B.
- G2/mitotic-specific cyclin-B3
- Serine/threonine-protein kinase PLK
- Rhodanese domain-containing protein.
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELHHPNIVCLQDVLMQDARLYLIFEFLSMDLKKYLDTIPSGQYLDRSRVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRSPEVLLGSALYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNDVWPDVESLQDYKNTFPKWKPGSLGTHVQNLDEDGLDLLSKMLIYDPAKRISGKMALNHPYFDDLDKSTLPANLIKKF
Protein: Putative RNA-guided DNA endonuclease Rv2885c (EC 3.1.21.-) (P9WL37)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: An RNA-guided dsDNA endonuclease. When guided by an RNA derived from the right-end element of its insertion sequence element (IS), cleaves DNA downstream of the transposon-associated motif (TAM). Cleaves supercoiled and linear DNA in a staggered manner 15-21 bases from the TAM yielding 5'-overhangs. Binds reRNA, an approximately 150 nucleotide base sRNA derived from the 3' end of its own gene, the right end (RE) of the insertion sequence (IS) plus sequence downstream of the IS.
Interaction partners:
- Probable resolvase
- Possible resolvase
- Uncharacterized protein Rv2886c
- Possible resolvase
- Probable transposase
- Possible resolvase
- Possible transposase
- Possible transposase
- Thiamine-monophosphate kinase
- Probable transposase
Sequence:
MMARLKVPEGWCVQAFRFTLNPTQTQAASLARHFGARRKAFNWTVTALKADIKAWRADGTESAKPSLRVLRKRWNTVKDQVCVNAQTGQVWWPECSKEAYADGIAGAVDAYWNWQSCRAGKRAGKTVGVPRFKKKGRDADRVCFTTGAMRVEPDRRHLTLPVIGTIRTYENTRRVERLIAKGRARVLAITVRRNGTRLDASVRVLVQRPQQRRVALPDSRVGVDVGVRRLATVADAEGTVLEQVPNPRPLDAALRGLRRVSRARSRCTKGSRRYCERTTELSRLHRRVNDVRTHHLHVLTTRLAKTHGRIVVEGLDAAGMLRQKGLPGARARRRALSDAALATPRRHLSYKTGWYGSSLVVADRWFPSSKTCHACRHVQDIGWDEKWQCDGCSITHQRDDNAAINLARYEEPPSVVGPVGAAVKRGADRKTGPGPAGGREARKATGHPAGEQPRDGVQVK
Protein: XK-related protein 6 (E9Q6C8)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000269|PubMed:25231987}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Lebercilin-like protein
Sequence:
MAAKSDGGGVGVGFAQLHNLDEAVGSGEEDGEPGGGGCGGGDGSEPGESSSLHICHCCNTSSCYWGCRSACLRSLLGKKPRRSAAAADGGDQPLQPPGAAGRHPPTPSAGRPQPASPQVERPWLDCLWIVLALLVFFGDVGTDLWLALDYYRKGDYGCFGLTLFFVLVPSLLVQSLSFRWFVQDYTGGGLGAVEGLSSRGPPMMGAGYGHGAARGGPGAGGSATPGAQRLCRLSVWIWQSVIHLLQMGQVWRYIRTMYLGIQSQRQKEHQRRFYWAMMYEYADVNMLRLLETFLESAPQLVLQLCIMIQKNSAETLPCVSSVTSLMSLAWVLASYHKLLRDSRDDKKSMSYRGALIHLFWRLFTISSRVISFALFASIFQLYFGIFVVVHWCAMAFWIIHGGTDFCMSKWEEILFNMVVGIVYIFCWFNVKEGRTRYRMFAYYTIVLTENAALTFLWYFYRNPESTDSYAVPALCCVFVSFVAGITLMLLYYGVLHPMGPRAKVFASSCCAELLWGIPLPPDVEPMAPQTPGYRGTQVTPTRAVTEQQEDLTADTCLPVFQVRPMGPSTPSGRPYHPEGPLIKIDMPRKRYPAWDAHFVDRRLRRTINILQYVTPTAVGIRYRDGPLLYELLQYESSL
Protein: Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) (P08752)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell membrane {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:P04899}; Lipid-anchor {ECO:0000250|UniProtKB:P04899}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody (By similarity). {ECO:0000250}.
Interaction partners:
- D
- Adenosine receptor A1
- Regulator of G-protein signaling 9
- Guanine nucleotide-binding protein G
- P2Y purinoceptor 12
- Guanine nucleotide-binding protein G
- Beta-2 adrenergic receptor
- Guanine nucleotide-binding protein G
- Mitogen-activated protein kinase 3
- Lysophosphatidic acid receptor 1
Sequence:
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPQRADDARQLFALSCAAEEQGMLPEDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITQSSLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Protein: 2-heptyl-4(1H)-quinolone synthase subunit PqsB (Q9I4X2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. PqsB, together with PqsC, catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and resulting in closure of the quinoline ring. PqsB is probably required for the proper folding of PqsC rather than for a direct enzymatic role in the process.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24239007}.
Interaction partners:
- 2-aminobenzoylacetyl-CoA thioesterase
- 2-heptyl-4
- Anthranilate--CoA ligase
- Anthraniloyl-CoA anthraniloyltransferase
- 2-heptyl-3-hydroxy-4
- Anthranilate synthase component 1, pyocyanine specific
- Anthranilate synthase component 2, pyocyanine specific
- Probable FAD-dependent monooxygenase
- Multiple virulence factor regulator MvfR
- HTH-type quorum-sensing regulator RhlR
Sequence:
MLIQAVGVNLPPSYVCLEGPLGGERPRAQGDEMLMQRLLPAVREALDEAAVKPEEIDLIVGLALSPDHLIENRDIMAPKIGHPLQKVLGANRAHVFDLTDSSLARALYVVDTLASDQGYRNVLVVRGESSQGLEVDSESGFALADGALALLCRPTGKAAFRRGALGGDPAQEWLPLSIPLNTDIRQVGDVKGHLNLPAQPGLPEAVRAGFTRLAGDFPQLNWVREEWFGQGRPDGRCLGPFELASQLRAAQRDRLDELLLISFDPFGMVVEGVTLELAGEAHA
Protein: 40S ribosomal protein S33, putative (Q57U30)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein translation factor SUI1 homolog, putative
- 60S ribosomal protein L19, putative
- 40S ribosomal protein S18, putative
- Polyubiquitin, putative
- 60S ribosomal protein L39, putative
- 60S ribosomal protein L5, putative
- Large ribosomal subunit protein eL18
- 40S ribosomal protein S26
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S16, putative
Sequence:
MCSSVAMAEVATAATTAATKKDKKAPQEEVVVQQTDQAQVGVIIKVLGRTGSRGNVTQVRVRLMAEEGSPEANRTIVRNVKGPCKEGDMLSLMETEREARRLR
Protein: Cytochrome c oxidase assembly protein COX20, mitochondrial (Q5RI15)
Organism: Homo sapiens (Human)
Function: Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:23125284, ECO:0000269|PubMed:29154948}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ubiquinol-cytochrome c reductase complex assembly factor 2
- Cytochrome c oxidase assembly protein COX18, mitochondrial
- Transmembrane protein 177
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase assembly factor 6 homolog
- Ubiquinol-cytochrome c reductase complex assembly factor 1
Sequence:
MAAPPEPGEPEERKSLKLLGFLDVENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNGSSSN
Protein: RE36563p (Q8IGS7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
VGFGCSFRALARSLAVARFPHTNSQLTRSHFDSDFIGLALLASSMLFARTTSSTSISPPAMMMQQHQQQQQQQDPQKLGQQFHQQPAFQLQQSFCETTYHMKILVPAVASGAIIGKGGETIASLQKDTGARVKMSKSHDFYPGTTERVCLITGSTEAIMVVMEFIMDKIREKPDLTNKIVDTDSKQTQERDKQVKILVPNSTAGMIIGKGGAFIKQIKEESGSYVQISQKPTDVSLQERCITIIGDKENNKNACKMILSKIVEDPQSGTCLNVSYADVSGPVANFNPTGSPYATNQNAINSSTASLNSTLGTTIGGANSAASLLVNGTGINLSINLGSPNPAPNLAVATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYGVLGMGVGVSHTNGAHSTLGNFLGVTTLDQQTAAAASAATASNVFGAVGQVNLEQYAAAVASAAAASRPTQSQLDAAAVQFDPFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPTPGDLSSKDSKNVEVPEVIIGAILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVTITGQPSAIAKAQYLIEQKINEEETKRARQIPLTTVVN
Protein: Neural lazarillo, isoform A (Neural lazarillo, isoform C) (RE67583p) (Q8SXR1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNHHSSSHLLLLISVVFGAVWVAHAQVPFPGKCPDVKLLDTFDAEAYMGVWYEYAAYPFAFEIGKKCIYANYSLIDNSTVSVVNAAINRFTGQPSNVTGQAKVLGPGQLAVAFYPTQPLTKANYLVLGTDYESYAVVYSCTSVTPLANFKIVWILTRQREPSAEAVDAARKILEDNDVSQAFLIDTVQKNCPRLDGNGTGLAGEDGLDVDDFVSTTVPNAIEKA
Protein: Euchromatic histone lysine methyltransferase 1 (A0A0D9SER3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAF
Protein: Mitogen-activated protein kinase 4b (EC 2.7.11.24) (MAP kinase 4b) (PpMPK4b) (A9S9Q8)
Organism: Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens)
Function: The CERK1, MEKK1a/b, MKK1a/b/c and MPK4a/b proteins are involved in pathogen defense. The pathway induces rapid growth inhibition, cell wall depositions and accumulation of defense-related transcripts. This protein may act redundantly with MPK4a in innate immunity triggered by pathogen-associated molecular patterns (PAMPs). May also be involved in resistance to necrotrophic fungi B.cinerea.
Interaction partners:
Sequence:
MDVAGAGGGGAADGNIQGVPTHNGEYTQYNIFGNLFEVSRKYVPPIRPIGRGAYGIVCSAVNSETGEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMDHENIVAIRDIIRPPTRENFNDVYIVYELMDTDLHQIIRSNQPLTEDHCQYFLYQLLRGLKYIHSAKVLHRDLKPSNLLLNANCDLKICDFGLARTTSETDFMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCIFMELLNREPLFPGRDYVQQLRLITELIGSPEDHDLGFLRSDNARRYIRQLPRFARQPLDRKFPNMGPAAIDLVEHMLRFDPARRITVEEALAHPYLATLHDINDEPICHSPFEFDFEQPSFTEEHIKELIMMEAIAFNPGNVGDMMS
Protein: Fatty acid desaturase (Q94541)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPPNAQAGAQSISDSLIAAASAAADAGQSPTKLQEDSTGVLFECDVETTDGGLVKDITVMKKAEKRLLKLVWRNIIAFGYLHLAALYGAYLMVTSAKWQTCILAYFLYVISGLGITAGAHRLWAHRSYKAKWPLRVILVIFNTIAFQDAAYHWARDHRVHHKYSETDADPHNATRGFFFSHVGWLLCKKHPEVKAKGKGVDLSDLRADPILMFQKKYYMILMPIACFIIPTVVPMYAWGESFMNAWFVATMFRWCFILNVTWLVNSAAHKFGGRPYDKFINPSENISVAILAFGEGWHNYHHVFPWDYKTAEFGKYSLNFTTAFIDFFAKIGWAYDLKTVSTDIIKKRVKRTGDGTHATWGWGDVDQPKEEIEDAVITHKKSE
Protein: Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) (O55166)
Organism: Rattus norvegicus (Rat)
Function: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q8N1B4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8N1B4}. Endosome membrane {ECO:0000250|UniProtKB:Q8N1B4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8N1B4}. Recycling endosome {ECO:0000250|UniProtKB:Q8N1B4}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex. {ECO:0000250|UniProtKB:Q8N1B4}.
Interaction partners:
- Vacuolar protein sorting-associated protein 51 homolog
- Vacuolar protein sorting-associated protein 53 homolog
- Vacuolar protein sorting-associated protein 54
- Syndetin
- Syntaxin-16
- Syntaxin-6
- Conserved oligomeric Golgi complex subunit 6
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Ras-related protein Rab-6A
- EARP and GARP complex-interacting protein 1
Sequence:
MAAAATMAAAARELVLRAGASDMEEEEGPLGAGSGLQEPLQLGELDITSDEFILDEVDVHIQANLEDELVKEALKTGVDLRHYSKQVELELQQIEQKSIRDYIQESENIASLHNQITACDAVLERMEQMLGAFQSDLSSISCEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSALVTAILEAPVTEPRFLEQLQELDAKAAAVREQEARGTAACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIPQTALLKYRFFYQFLLGNERATAKEVRDEYVETLSKIYLSYYRSYVGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKPSLRSRNTIFTLGTRGAVISPAELEAPILVPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFVVSGPAAHDLFHAVMGRTLSMTLKHLESYLADCYDAIAVFLCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSINQTIPNERTLQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEFIEELLSPPFGGLVAFVKEAEALIERGQAERLRGEEARVTQLIRGFGSSWKASVESLSQDVMRSFTNFRNGTSIIQGALTQLIQLYHRFHRVLSQPQLRALPARAELINIHHLMVELKKHKPNF
Protein: HID1 domain containing (E9PMS4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGSTDSKLNFRKAVIQLTTKTQGEEDDEHARPLAESLLLAIADLLFCPDFTVQSHRRSTVDSAEDVHSLDSCEYIWEAGVGFAHSPQPNYIHDMNRMELLKLLLTCFSEAMYLPPAPESGSTNPWVQFFCSTENRHALPLFTSLLNTVCAYDPVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSASSASPTVDGTTTGTAMDDADPPGPENLFVNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPNS
Protein: Nonspecific ribonucleoside hydrolase (Q9I6Y9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Adenine deaminase
- Probable purine/pyrimidine phosphoribosyl transferase
- Ribokinase
- AMP nucleosidase
- Guanine deaminase
- Adenine phosphoribosyltransferase
- Xanthine phosphoribosyltransferase
- nicotinamidase
- Probable hydrolase
- Guanine deaminase
Sequence:
MSRAARPCNRFCSLLLGLALLMPASLPLSAAETVAPPSPRTLIIDTDPGADDVIALLFAMASPKELKIQALTTVAGNVPLEKTARNARLAREWGKRPDIPVYAGAPRPLLRTPIYAADVHGSEGISGVEVHEPKQPLAEGNAVDYLIRTLRAAPEKSVTLAMLGPETNLALALTQAPDIVKGVREIVIMGGAHFNGGNITPAAEFNIFADPHAAEIVLKSGAPITMLPLDVTHKILTSPERIAKLRNLGNQAGKTVADILDAYVQYDIKYYGLKGGPVHDATVVAYLLKPSLFKGKRINVQVDSREGITFGQTVADWYGGLKQPANVEWINEGDAQGFFDLLTERIARLP
Protein: Vacuolar amino acid transporter 7 (P40501)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable amino acid transporter of unknown specificity.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:11274162}; Multi-pass membrane protein {ECO:0000269|PubMed:11274162}.
Interaction partners:
- Vacuolar amino acid transporter 4
- Vacuolar amino acid transporter 3
- Vacuolar amino acid transporter 1
Sequence:
MEATSSALSSTANLVKTIVGAGTLAIPYSFKSDGVLVGVILTLLAAVTSGLGLFVLSKCSKTLINPRNSSFFTLCMLTYPTLAPIFDLAMIVQCFGVGLSYLVLIGDLFPGLFGGERNYWIIASAVIIIPLCLVKKLDQLKYSSILGLFALAYISILVFSHFVFELGKGELTNILRNDICWWKIHDFKGLLSTFSIIIFAFTGSMNLFPMINELKDNSMENITFVINNSISLSTALFLIVGLSGYLTFGNETLGNLMLNYDPNSIWIVIGKFCLGSMLILSFPLLFHPLRIAVNNVIIWIEITYGGANPEEDPQVSEYTRASNLRPISMTVEDPAQPSDALDATSYNEQECLLPNGNFDNGSIESQENNNDERGTMAVAGDNEHHAPFVKSRFYWITALLLISMYTLALSVQSFALVLSFVGATGSTSISFTLPGLLGYKLIGLDSLAIGKMIPPKDRFYKRCSLLLVFYGLSVMFLSLYVTVFNRSDEA
Protein: AAD14 protein (Q99415)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
PHTLLEDHLLREFFHPLFFLQAPLLLSLPAQYNAFLSGSVWTPGSPREPKQAKERTGAKILVGEIGCLAFFEDIFGARVALGWGLVLQGIQPGPKMDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPSVSPVVPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQSPHPLSQFAQLQSQSVHPGLLHSSPTAFRAPPFVQLHRHPPPFLQARQPAQSQ
Protein: Putative coenzyme F420-dependent oxidoreductase Rv3520c (EC 1.-.-.-) (O53565)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- ChsH2 C-terminal OB-fold domain-containing protein
- Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3
- Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4
- Uncharacterized protein Rv0940c
- Bifunctional F420 biosynthesis protein FbiB
- Deazaflavin-dependent nitroreductase
- Putative F420H
- Phosphoenolpyruvate transferase
- F420H
- F420H
Sequence:
MEAGMKLGLQLGYWGAQPPQNHAELVAAAEDAGFDTVFTAEAWGSDAYTPLAWWGSSTQRVRLGTSVIQLSARTPTACAMAALTLDHLSGGRHILGLGVSGPQVVEGWYGQRFPKPLARTREYIDIVRQVWARESPVTSAGPHYRLPLTGEGTTGLGKALKPITHPLRADIPIMLGAEGPKNVALAAEICDGWLPIFYSPRMAGMYNEWLDEGFARPGARRSREDFEICATAQVVITDDRAAAFAGIKPFLALYMGGMGAEETNFHADVYRRMGYTQVVDEVTKLFRSGRKDEAAEIIPDELVDDAVIVGDIDHVRKQMAVWEAAGVTMMVVTAGSAEQVRDLAALV