wanglab/gogpt-training-data huggingface dataset:
Protein: G-protein coupled receptor-associated sorting protein 1 (GASP-1) (Q5JY77)
Organism: Homo sapiens (Human)
Function: Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15452121}.
Interaction partners:
- Delta-type opioid receptor
- Mu-type opioid receptor
- Beta-2 adrenergic receptor
Sequence:
MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQTNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIGSWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCEMFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESSSCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQGKTDNQNDPEGDQEN
Protein: Putative phosphoserine aminotransferase (PSAT) (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (Q10349)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
Interaction partners:
- Putative D-3-phosphoglycerate dehydrogenase
- Probable phosphoserine phosphatase
- Threonine synthase
- Cysteine synthase 1
- Cysteine synthase 2
- 2-hydroxyacid dehydrogenase homolog 2
- 2-hydroxyacid dehydrogenase homolog 1
- Serine hydroxymethyltransferase, mitochondrial
- Probable prephenate dehydrogenase [NADP
- Tryptophan synthase
Sequence:
MSSREEVVNFAAGPAAMITSVVEEFGKDFVNFQGLGMGVAEISHRSKQGSGIVTSAESNFRKLYNIPENFHILFMQGGGTEQFAACLYNVYAHHALKNGNAKSLVANYIITGAWSKKAYAEAERLGFPCHVAVDMKELAGKYGSLPEDKDLKFTPDGETSLVYYCDNETVHGVEFNEPPTNIPKGAIRVCDVSSNFISRKIDFTKHDIIFAGAQKNAGPAGITVVFVRDSVLARPTPAELHKLNIPVSPTVSDYKIMADNHSLYNTLPVATLHAINLGLEYMLEHGGLVALEASSIEKSKLLYDTLDKHDLYISVVEPAARSRMNVTFRIEPQELESEFLAEAEKHHLVQLKGYRSVGGIRASLYNAISVEQTRRLIDLLESFAKAHSN
Protein: Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3) (GABAAR subunit alpha-3) (P20236)
Organism: Rattus norvegicus (Rat)
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P14867}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P14867}; Multi-pass membrane protein.
Interaction partners:
- Trafficking kinesin-binding protein 2
- Huntingtin-associated protein 1
- Vesicle-fusing ATPase
- Inactive phospholipase C-like protein 1
- Gamma-aminobutyric acid type B receptor subunit 2
- Gamma-aminobutyric acid receptor subunit beta-3
- Gamma-aminobutyric acid receptor subunit beta-1
- Gamma-aminobutyric acid receptor subunit beta-2
- Gamma-aminobutyric acid receptor-associated protein
- Gamma-aminobutyric acid receptor subunit theta
Sequence:
MITTQMWHFYVTRVGLLLLISILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKTSTTFNIVGTTYPINLAKDTEFSTISKAAAAPSASSTPTVIASPKTTYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
Protein: Guanylate cyclase (EC 4.6.1.2) (M9NFA6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MFAHPCPAPAGNYHSGLLHPLLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLPRNSLTRSSSLESPKKLRFAAGSLLEHHRYHSDEALLEVDSYTGLRRSSGGSTQSRYEETTLSLTLSCQSIEIVGGQHNKRRPSSYPTANTPLLMNHVEV
Protein: Homeobox-leucine zipper protein ATHB-6 (HD-ZIP protein ATHB-6) (Homeodomain transcription factor ATHB-6) (P46668)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that may act as growth regulators in response to water deficit. Interacts with the core sequence 5'-CAATTATTA-3' of promoters in response to ABA and in an ABI1-dependent manner. Involved in the negative regulation of the ABA signaling pathway.
Subcellular location: Nucleus.
Interaction partners:
- Protein phosphatase 2C 56
- E3 ubiquitin-protein ligase AIP2
- BTB/POZ and MATH domain-containing protein 6
- Transducin/WD40 repeat-like superfamily protein
- BTB/POZ and MATH domain-containing protein 1
- BTB/POZ and MATH domain-containing protein 3
Sequence:
MMKRLSSSDSVGGLISLCPTTSTDEQSPRRYGGREFQSMLEGYEEEEEAIVEERGHVGLSEKKRRLSINQVKALEKNFELENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWKTKQLEKDYGVLKTQYDSLRHNFDSLRRDNESLLQEISKLKTKLNGGGGEEEEEENNAAVTTESDISVKEEEVSLPEKITEAPSSPPQFLEHSDGLNYRSFTDLRDLLPLKAAASSFAAAAGSSDSSDSSALLNEESSSNVTVAAPVTVPGGNFFQFVKMEQTEDHEDFLSGEEACEFFSDEQPPSLHWYSTVDHWN
Protein: MHC class I-like protein MILL1 (MHC class I-like located near the leukocyte receptor complex 1) (Q8HWE7)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000269|PubMed:16920948}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:16920948}.
Interaction partners:
- Transferrin receptor protein 1
Sequence:
MLLSRNLRALAAIHLWIVYLLLEDLLGTCAEGDNQRLVASAPYQDIEITLEKPRVQAVAEPHTLRYDLMALSLEVPGLPQFLTLRYFDDEPFLPYKKNSSITDSQEPRIKDHLRAETWGRETDDLQEEEEQLKGMLAEITAQNGQNTDLHILQATFGCELQRNGSTRGFWKLGYDGQNFLTFDQKTLTWTVDGPSTQKNKTFWKTRAPRADLVKTFLDDICPAQLQRYLASLRNGLLNTGFPKVIVTFRNYPVGRITLTCRAFRLYTRVATLTWLQYRKPVQQKTFGSETILPSGDGTYQAWVSIRVLPGQESQFSCNLKHGNHNINEPAATEAPVYGARREQPPTSGVGSRVGKSLWSAMTTALVVISWTLSQKLMGPLLWFCSGGFCSFLQCW
Protein: Calcium-transporting ATPase 4, plasma membrane-type (EC 7.2.2.10) (Ca(2+)-ATPase isoform 4) (O22218)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into small vacuoles.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:11115896, ECO:0000269|PubMed:17151019}; Multi-pass membrane protein {ECO:0000255}. Note=Tonoplast. Small vacuoles. {ECO:0000269|PubMed:11115896}.
Interaction partners:
- AT5G44290 protein
- Glutamate receptor 2.3
- LONGIFOLIA protein
- Ras-related protein RABH1c
- At1g64330
- Aspartic proteinase PCS1
Sequence:
MSNLLRDFEVEAKNPSLEARQRWRSSVSIVKNRTRRFRNIRDLDKLADYENKKHQIQEKIRVAFFVQKAALHFIDAAARPEYKLTDEVKKAGFSIEADELASMVRKNDTKSLAQKGGVEELAKKVSVSLSEGIRSSEVPIREKIFGENRYTEKPARSFLMFVWEALHDITLIILMVCAVVSIGVGVATEGFPRGMYDGTGILLSILLVVMVTAISDYKQSLQFRDLDREKKKIIVQVTRDGSRQEISIHDLVVGDVVHLSIGDQVPADGIFISGYNLEIDESSLSGESEPSHVNKEKPFLLSGTKVQNGSAKMLVTTVGMRTEWGKLMETLVDGGEDETPLQVKLNGVATIIGKIGLSFAVLTFVVLCIRFVLDKATSGSFTNWSSEDALTLLDYFAISVTIIVVAVPEGLPLAVTLSLAFAMKKLMSDRALVRHLAACETMGSSTCICTDKTGTLTTNHMVVNKVWICDKVQERQEGSKESFELELSEEVQSTLLQGIFQNTGSEVVKDKDGNTQILGSPTERAILEFGLLLGGDFNTQRKEHKILKIEPFNSDKKKMSVLIALPGGGARAFCKGASEIVLKMCENVVDSNGESVPLTEERITSISDIIEGFASEALRTLCLVYKDLDEAPSGELPDGGYTMVAVVGIKDPVRPGVREAVQTCQAAGITVRMVTGDNISTAKAIAKECGIYTEGGLAIEGSEFRDLSPHEMRAIIPKIQVMARSLPLDKHTLVSNLRKIGEVVAVTGDGTNDAPALHEADIGLAMGIAGTEVAKENADVIIMDDNFKTIVNVARWGRAVYINIQKFVQFQLTVNVVALIINFVSACITGSAPLTAVQLLWVNMIMDTLGALALATEPPNEGLMKRAPIARTASFITKTMWRNIAGQSVYQLIVLGILNFAGKSLLKLDGPDSTAVLNTVIFNSFVFCQVFNEINSREIEKINVFKGMFNSWVFTWVMTVTVVFQVIIVEFLGAFASTVPLSWQHWLLSILIGSLNMIVAVILKCVPVESRHHHDGYDLLPSGPSSSNSA
Protein: Anthranilate phosphoribosyltransferase (PRtransferase) (EC 2.4.2.18) (P07285)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA), the second step in tryptophan biosynthesis.
Interaction partners:
- Multifunctional tryptophan biosynthesis protein
- Tryptophan synthase
- Anthranilate synthase component 1
- N-
- Aminodeoxychorismate synthase
- Chorismate synthase ARO2
- Histidine biosynthesis trifunctional protein
- Pentafunctional AROM polypeptide
- 1-
- Histidinol-phosphate aminotransferase
Sequence:
MSEATLLSYTKKLLASPPQLSSTDLHDALLVILSLLQKCDTNSDESLSIYTKVSSFLTALRVTKLDHKAEYIAEAAKAVLRHSDLVDLPLPKKDELHPEDGPVILDIVGTGGDGQNTFNVSTSAAIVASGIQGLKICKHGGKASTSNSGAGDLIGTLGCDMFKVNSSTVPKLWPDNTFMFLLAPFFHHGMGHVSKIRKFLGIPTVFNVLGPLLHPVSHVNKRILGVYSKELAPEYAKAAALVYPGSETFIVWGHVGLDEVSPIGKTTVWHIDPTSSELKLKTFQLEPSMFGLEEHELSKCASYGPKENARILKEEVLSGKYHLGDNNPIYDYILMNTAVLYCLSQGHQNWKEGIIKAEESIHSGNALRSLEHFIDSVSSL
Protein: Malic enzyme (A0A060X1Z3)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Uncharacterized protein
- malate synthase
- Malate dehydrogenase
- Malate dehydrogenase
- Malate dehydrogenase, cytoplasmic
- Pyruvate kinase
- Pyruvate kinase
- Pyruvate kinase
- Pyruvate kinase
- Pyruvate kinase C-terminal domain-containing protein
Sequence:
MSLLRFCVFQGMAFSLEERLQLGIHGLLPPCFLSQDVQLLRVLKNYEMKRDDLDRYVFLMGLQDRNEKLFYRVLTSDTERFMPIVYTPTVGLACQMYGLAFRRPRGLFITIHDLTHISTVLQSWPEKDIRAVCVTDGERILGLGDLGCYGMGIPVGKLALYTACGGMPPQQCLPVMLDVGTDNEELLKDPLYIGLRHKRIRGQAYDDLLEEFMKAVSDRYGMDCLIQFEDFANTNAFRLLSKYRDQYCTFNDDIQGTAAVAVAGLLAALRVTKSKMSDHTIVFQGAGEAAMGIADLITMAMEKEGLSEDEALRKIWMVDSKGLIVKGRDHLTHEKERFAHEHKQMRNLVDVVHELKPTAIIGVAAISGAFTEEIIRDMASFNERPIIFALSNPTSKAECTAEQCYTITEGRGIFASGSPFDPVTLPDGRTFFPGQGNNAYVFPGVGLGVTACAIRHITDEIFLTTAETIADLVTEKDLSEGRLYPPLNTIRDVSLKLAVKIVEFAYEHKLATLYPEPEDKEAFVRSLIYSPDYDEFAVDSYRWPEDAMTIQSCKL
Protein: Forkhead box protein L2 (Pituitary forkhead factor) (P-Frk) (O88470)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:19797124}.
Interaction partners:
- Transcription factor SOX-9
- Steroidogenic factor 1
- Mothers against decapentaplegic homolog 3
- Muellerian-inhibiting factor
- Sex-determining region Y protein
- Doublesex- and mab-3-related transcription factor 1
- Mothers against decapentaplegic homolog 4
- Protein Wnt-4
- Aromatase
- R-spondin-1
Sequence:
MMASYPEPEDTAGTLLAPESGRAVKEAEASPPSPGKGGGTTPEKPDPAQKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGSGGAAGGCGVPGAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSPGAAAVVKGLAGPAASYGPYSRVQSMALPPGVVNSYNGLGGPPAAPPPPPPPPHPHPHPHAHHLHAAAAPPPAPPHHGAAAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSYWDHDSKTGALHSRLDL
Protein: Kinesin-like motor protein 9 (Q1MTQ7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Kinesin-like motor protein involved in anaphase B spindle elongation.
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm, cytoskeleton.
Interaction partners:
- Anaphase spindle elongation protein 1
- Microtubule integrity protein mal3
- Tubulin alpha-2 chain
- Phosphoprotein p93
- Kinesin-like protein 2
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- Microtubule protein alp7
- Kinesin-like protein cut7
Sequence:
MIQIFLRVKKAQPSSDASNKYGFLTVLNDYEILLESPEDSHAYRVSKSKTLEKASFTKVFPPSCTQLDVFSTICAPLIADSLVNMNDTLLFTLGVSGAGKTYTLFGPSDRPGVAFLALDALFYAIKGREASPQTVEFLRSQLEKCKIVEASKFLRGEAPLDIKVPNTEYYASHFPKIEEKNYQYAIYLSFAEIYNDRIFDLLEKASFFGHRHALSLKKSSTSDKKSIAGIQKVFVSNTTEAYKLIQKVLQLRKSTSTKSNSVSSRSHLIMSIELFKVCTKSNKFESCQIDLVDLAGSERTRSAETSGLLLREGASINRSLLTLGQCLEALRRKHEGKQHIIPFRQSKLTELLFHSGHLSGLAGINMLVNIDPFGSFDENAQVMRYSANAREILPPPLNENSGSQSPSHSLLQKSKNTSSTKALTSHLEQLQQENQQLRMLLADADSEMMNLEYEIRQQMTREMEERVSEVERTFLTKLLEESAQGIEYTDQKLEKMGGWMKKLQDENSEKTETIAQLEQIIEELHEELRSLEEESIKESSATQQNENQHKRSSRKLLYEDKQAIQEAHTINTKRKLWPQSTLIQAPNSDDEENVPSPSPKKKVVSPIKPLSPSRRPPLTSLYSGTTDIDINEL
Protein: Cupincin (EC 3.4.-.-) (52 kDa globulin-like protein) (allergen Ory s NRA) (B8AL97)
Organism: Oryza sativa subsp. indica (Rice)
Function: Seed storage protein (Probable). Globulin-like protein that acts as zinc metalloprotease. Cleaves specifically between Leu-15 and Tyr-16 of insulin B chain, and Gln-1 and Leu-2 of neurotensin (NT) peptide in vitro. May play a role as an initiating endopeptidase in germinating seeds.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MAKKKTSSSMARSQLAALLISLCFLSLASNAVGWSRRGEREEEDERRRHGGEGGRPYHFGEESFRHWTRTRHGRFSVLERFPDEQVVGAAVGGYRVAVLEAAPRAFLQPSHYDADEVFYVKEGEGVIVLLREGRKESFCVREGDAMVIPAGAIVYSANTHSSKWFRVVMLLNPVSTPGHFEEYFPVGGDRPESFFSAFSDDVLQAAFNTRREELEKVFERQREGGEITTAPEEQIRELSKSCSRGGGGGSGSEWEIKPSSLTGKSPYFSNNHGKLFELTGDECRHLKKLDLQIGLANITRGSMIAPNYNTRATKLAVVLQGSGYFEMACPHVSGGGSSERREREREHGRRREEEQGEEEHGERGEKARRYHKVRAQVREGSVIVIPASHPATIVASEGESLAVVCFFVGANHDEKVFLAGRNSPLRQLDDPAKKLVFGGSAAREADRVLAAQPEQILLRGPHGRGSVSDM
Protein: Bactericidal protein diptericin B (Q9BJF2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
LFIGLACAFSSAWAYPYPDLREIVNLQPEPLAYAPNFDVPLHRVRRQLQLNGGGGGSPKQGFDLSLNGRAPVWQSPNGRHSFDATGSYAQHLGGPYGNSRPQWGAGGVY
Protein: Biotin synthase (EC 2.8.1.6) (O59778)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the last step of biotin biosynthesis, the conversion of dethiobiotin to biotin.
Interaction partners:
- Biotin--protein ligase
- Mitochondrial tRNA-specific 2-thiouridylase 1
- Uncharacterized aminotransferase C1771.03c
- Ornithine aminotransferase car2
- Uncharacterized aminotransferase C1039.07c
- Dihydroxy-acid dehydratase, mitochondrial
- Vitamin H transporter 1
- Lipoyl synthase, mitochondrial
- Putative thiosulfate sulfurtransferase, mitochondrial
- 5-aminolevulinate synthase, mitochondrial
Sequence:
MFTRTIRQQIRRSSALSLVRNNWTREEIQKIYDTPLIDLIFRAASIHRKFHDPKKVQQCTLLSIKTGGCTEDCKYCAQSSRYNTGVKATKLMKIDEVLEKAKIAKAKGSTRFCMGSAWRDLNGRNRTFKNILEIIKEVRSMDMEVCVTLGMLNEQQAKELKDAGLTAYNHNLDTSREYYSKIISTRTYDERLNTIDNLRKAGLKVCSGGILGLGEKKHDRVGLIHSLATMPTHPESVPFNLLVPIPGTPVGDAVKERLPIHPFLRSIATARICMPKTIIRFAAGRNTCSESEQALAFMAGANAVFTGEKMLTTPAVSWDSDSQLFYNWGLEGMQSFEYGTSTEGEDGTFTLPPKERLAPSPSL
Protein: Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain] (Q8CHN8)
Organism: Rattus norvegicus (Rat)
Function: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development.
Subcellular location: Secreted {ECO:0000269|PubMed:12847554}.
Interaction partners:
- Mannose-binding protein C
- Ficolin-2
- Ficolin-1
- Plasma protease C1 inhibitor
- Complement C4
- Mannose-binding protein A
- Mannan-binding lectin serine protease 2
- Complement C4A
- Collectin-11
- Complement C2
Sequence:
MRFLSFRRLLLYHVLCLTLTEVSAHTVELNEMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRVQLYFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSVTFRSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSGNLFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVTLQFEDIFDIEDHPEVPCPYDYIKIKAGSKVWGPFCGEKSPEPISTQSHSIQILFRSDNSGENRGWRLSYRAAGNECPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEVMDTFQIECLKDGAWSNKIPTCKIVDCGVPAVLKHGLVTFSTRNNLTTYKSEIRYSCQQPYYKMLHNTTGVYTCSAHGTWTNEVLKRSLPTCLPVCGLPKFSRKHISRIFNGRPAQKGTTPWIAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHHPLDPEEPILHNSHLLSPSDFKIIMGKHWRRRSDEDEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEHPSTEGTMVIVSGWGKQFLQRLPENLMEIEIPIVNYHTCQEAYTPLGKKVTQDMICAGEKEGGKDACAGDSGGPMVTKDAERDQWYLVGVVSWGEDCGKKDRYGVYSYIYPNKDWIQRVTGVRN
Protein: Protein REVEILLE 6 (Q8H0W3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Protein LNK1
- Protein LNK2
- Transcription factor LUX
- WD repeat-containing protein LWD2
- WD repeat-containing protein LWD1
- Two-component response regulator-like APRR5
- Two-component response regulator-like APRR1
- Protein EARLY FLOWERING 4
- Two-component response regulator-like APRR9
- Two-component response regulator-like APRR7
Sequence:
MVSRNSDGYFLDPTGMTVPGLGPSFTAAVSSSSSPTTSSTAVAVADVTAMVSSSEEDLSKKIRKPYTITKSRESWTEPEHDKFLEALQLFDRDWKKIEAFIGSKTVIQIRSHAQKYFLKVQKSGTGEHLPPPRPKRKAAHPYPQKAHKNVQLQVPGSFKSTSEPNDPSFMFRPESSSMLMTSPTTAAAAPWTNNAQTISFTPLPKAGAGANNNCSSSSENTPRPRSNRDARDHGNVGHSLRVLPDFAQVYGFIGSVFDPYASNHLQKLKKMDPIDVETVLLLMRNLSINLSSPDFEDHRRLLSSYDIGSETATDHGGVNKTLNKDPPEIST
Protein: Prothoracicotropic hormone, isoform F (X2JCX9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cytochrome P450 302a1, mitochondrial
- Spookier
- GEO10744p1
- Cholesterol 7-desaturase nvd
Sequence:
MDIKVWRLLGQSCRRSTALVRHRSSMMPWLPISIMAMALLSLTNKGIASQYASDEGLDEMVGLRSLEHRAEEQQPDRSTSKMLSALFGFSPSTPHPTEMAMVMPHQLPPMYYNDFYEDLVTTKRNDVHSAGCDCKVTNELVDLGGLHFPRFLMNAVCESGAGRDLAKCSHGSNCRPLEYKVKVLAQTSQSDHPYSWMNKDQPWQFKTVTVTAGCFCTK
Protein: Cytochrome c oxidase polypeptide VIII, mitochondrial (Q9P4W1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P04039}; Single-pass membrane protein {ECO:0000250|UniProtKB:P04039}.
Interaction partners:
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome c oxidase polypeptide 5, mitochondrial
- Cytochrome c oxidase subunit 9, mitochondrial
- Cytochrome c oxidase subunit 12, mitochondrial
- Cytochrome c oxidase subunit 13, mitochondrial
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 7
- Cytochrome b-c1 complex subunit 10
Sequence:
MLRYSLQARSALRGVRFSSSHSAPKPGSTIPFYINKKPLPTLLYFGTFGVIFSIPFIVVKYHNRNL
Protein: Calcium/calmodulin-dependent protein kinase II (EC 2.7.11.17) (P22517)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Important in cellular regulation.
Interaction partners:
- Calmodulin
- Calcineurin subunit B
- Serine/threonine-protein phosphatase 2B catalytic subunit A1
- Serine/threonine-protein phosphatase 2B catalytic subunit A2
- EH domain-containing and endocytosis protein 1
- Transcriptional regulator CRZ1
- Regulator of calcineurin 2
- Suppressor of yeast profilin deletion
- GTPase-activating protein GYP7
- Protein DIA1
Sequence:
MPKESEVINSEFHVDVQDPERLNGHPVAKFINKLSGQPESYVNRTNYIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDDPWITSKRVETSNILPDVKKGFSLRKKLRDAIEIVKLNNRIKRLRNMYSLGDDGDNDIEENSLNESLLDGVTHSLDDLRLQSQKKGGELTEEQMKLKSALTKDAFVQIVKAATKNKHKVLAGEEEDDSKKTLHDDRESKSED