wanglab/gogpt-training-data huggingface dataset:
Protein: Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) (mVparp) (E9PYK3)
Organism: Mus musculus (Mouse)
Function: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8K3Y6}. Nucleus {ECO:0000250|UniProtKB:Q8K3Y6}. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250|UniProtKB:Q8K3Y6}.
Interaction partners:
- Major vault protein
- Telomerase protein component 1
- Caspase-3
- Caspase-9
- Caspase-7
- Granzyme B
- Protein mono-ADP-ribosyltransferase PARP16
- Protein mono-ADP-ribosyltransferase PARP9
- Protein mono-ADP-ribosyltransferase PARP6
- Protein mono-ADP-ribosyltransferase PARP14
Sequence:
MTLGIFANCIFCLKVKYLPRQQKKKLQTDIKENGGKFSFLLNPQCTHVIVDSADVLSRCHLNSIQKNDVQIANPAFIQDSVRQRRLLDVRNYDPLSPAPAAPPAERSRSEVQSEYLPSDNTPEKENTEVTEVSAENVEIPPFLQDFEVVKYNILEKVGGPETVVVELQSSQDPESCPFVITAHFLLADQKTRRESTGKQTSEGAIEYYESYVEDLKRQGFLLQEHFTAEATQLASEKLQALLLEEVISSGALSQEVSDLLEVIWTEALGHLENTLLKPVNSMSLNDVSKAEGILLLVKTALKNGDSPGQLQKTMAEFYRLLPHRHPASEEVNLRLLAQKEDLCQLVRDMVNVCETNLSKPNPPSLAKYRALRCKIEHVDQNTEEFSRVRKEVLQNNRSEQPVDILQIFRVGRVNEATEFLSKLGNVRLLFHGSPVRNILGILSRGLLLPKVAEDRGVQRTDVGNLGSGIYFSDSLSTSIKYAHAGETDGSRLLVVCDVALGKCVNLFKKDFSLTEAPPGYDSVHGVSETTSVPTDFQDDEFVVYKTNQVKMKYIVKFCTPGDQIKEFHPHENTEVEEQRAEPSSVPEAGDFQLPDIKPFTNIKAGLQDASANPVPLDSVHIKGRVIDFVAQVIVFQTYTNQSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIVGEIKEKEEARQEYREAVSQGHGAYLMDQDTPDVFTVSVGNLPPRAKVLIKITYITELSIQSPVAIFFIPGTVAPWQQDKALNENLQDTVETIRIKEIGAEQSFSLAMSIEMPYMIEFISSDTHELRQKSTDCKAVVSTVEGSSLDSGGFSLHIGLRDAYLPRMWVEKHPEKESEACMLVFQPELADVLPDLRGKNEVIICLDCSSSMEGVTFTQAKQVALYALSLLGEEQKVNIMQFGTGYKELFSYPKCITDSKMATEFIMSAAPSMGNTDFWKVLRYLSLLYPSEGFRNILLISDGHLQSESLTLQLVKRNIQHTRVFTCAVGSTANRHILRTLSQCGAGVFEYFNSKSKHSWKKQIEAQMTRIRSPSCHSVSVKWQQLSRDAPEPLQAPAWVPSLFHNDRLLVYGFIPHCTQATLQAFIQEKEFCTMVSTTELQKTTGTMIHKLAARALIRDYEDGILHDDETNHEMKKNIMKSLIIELSKENSLITQFTSFVAVEKRDVNEIPFANVPNISELVAKEDVDFLPYVSWQEKQPEASISQTEIDSSRLKHNKLSDGHGVLQPVSVSSEVNEKPSLLLAAKKRKIKTIKKCSLDISEDFEDRTAVAQSPATAQSLNFHLPLSVRPQLKAVEQQLHGNRLEPKQRGGFRKLLMAKKCRNVPDSLVSSAPAVTAEFSYLSACSSSSAFLSPLCDIPSSLPPHPLGGTHPPPPLPLPDGTHLPSPLFGSTHPPPPLFGGTLIPPPSSLFGGTHLPPPPPLPGGTHIPPPPPIPGGTLIPPSSSLFGGTHLPPPPLLSAGTHIPPPPLLSAGTHLPPPPLLPAGTHIPPPPPITGSTHPPPPSSLFGGTHLPPPPPLPGGTHIPPPPPIPGGTLIPSPSSLFGGTHLPPPPLLPAGTHIPPPPPITGSTHPPPPSSLFGGTHLPPPPPAGTQFSLSPIGFIPPKLGPPKLSHSHKLVGDTNIHDSEPPLLGFKDLCSRDMGFSCGTAFSGSFASSKDFDPGKFSQGPNNISFSPKAPEMGVLHQSPFCSPPKPPSAPPLVTNVLCSEAPQSYFLNLQSAAVHQSPNNRVSEIIMESVESSLPSDYSSRDASSYLALEGAEDSLLGGSSFETDTDEAAAFIANDLLTSIETSSDEECAFCDEDQESPVPWASLFALQTENGFWKLTPELGLILNLNVNALLTSLEEKGIRSLGTKGRERLLDLIATLLVLQFLYTKLEQEGMVAKSLIKMDDAFISRNIPWAFENIKKAREWARKTEGQYPSICQRLELGKDWESATKQLLGIQPQANTSLHRILYYSQG
Protein: Heterochromatin protein 1 (Q1K612)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone H3
- DNA
- Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5
- Histone H3-like centromeric protein hH3v
- SET-5
- Histone deacetylase
- SET-7
- Ubiquitin ligase subunit CulD
- Chromodomain-helicase-DNA-binding protein 4
- CDP-2-and HDA-1 associating protein
Sequence:
MPYDPSALSDEEAASSVELDTRSATSSSKKQSRDKKSVKYTIPEPEDFEDEEQNGDGADEGGEDDEEGDEEEEDVYVVEKILDHMLNDDNEPLFLVKWEGYEKKSDQTWEPEDTLIEGASERLKEYFTKIGGREKIFEASAAAQKIKKRGRPSSNSGTPQASSNKRSRKNGDHPLNSEEPQTAKNAAWKPPAGSWEEHIAQLDACEDEDTHKLMVYLTWKNGHKTQHTTDVIYKRCPQKMLQFYERHVRIIKRDPDSEDREGSVSQ
Protein: Uncharacterized protein (Q57Z10)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSGVVIKKPNLKRLLAGQREELASFQPPVHPIPEYLGSPLPYLSNPYHIRGTLMAVEQEPEPNHEADGGKQLMADIMNERARICLEVEKTLALTCRVLDKAAQNDGELTELARESLARLTVMGEDLSNRMITSRE
Protein: Cytochrome P450 2C70 (EC 1.14.14.-) (CYPIIC70) (Cytochrome P-450Md) (Cytochrome P450 P49) (P19225)
Organism: Rattus norvegicus (Rat)
Function: A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis. Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively. May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- UDP-glucuronosyltransferase 2B1
- Cytochrome P450 1A2
- Cytochrome P450 2E1
- Cytochrome P450 1A1
- Bifunctional epoxide hydrolase 2
- Cytochrome P450, family 2, subfamily j, polypeptide 4
- Cytochrome P450 2U1
- Alanine--glyoxylate aminotransferase
- Epoxide hydrolase 1
- Cytochrome P450 7A1
Sequence:
MALFIFLGIWLSCLVFLFLWNQHHVRRKLPPGPTPLPIFGNILQVGVKNISKSMCMLAKEYGPVFTMYLGMKPTVVLYGYEVLKEALIDRGEEFSDKMHSSMLSKVSQGLGIVFSNGEIWKQTRRFSLMVLRSMGMGKRTIENRIQEEVVYLLEALRKTNGSPCDPSFLLACVPCNVISSVIFQHRFDYSDEKFQKFIENFHTKIEILASPWAQLCSAYPVLYYLPGIHNKFLKDVTEQKKFILMEINRHRASLNLSNPQDFIDYFLIKMEKEKHNEKSEFTMDNLIVTIGDLFGAGTETTSSTIKYGLLLLLKYPEVTAKIQEEITRVIGRHRRPCMQDRNHMPYTDAVLHEIQRYIDFVPIPLPRKTTQDVEFRGYHIPKGTSVMACLTSALHDDKEFPNPEKFDPGHFLDEKGNFKKSDYFMAFSAGRRACIGEGLARMEMFLILTSILQHFTLKPLVNPEDIDTTPVQPGLLSVPPPFELCFIPV
Protein: Glutamine-rich protein (P86727)
Organism: Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone)
Subcellular location: Secreted {ECO:0000269|PubMed:21050442}.
Interaction partners:
Sequence:
MAAYCQAQGLDVVLAALLGAINQQPSRQQFQQQQQQQRQPQLQQQQQQQGIQQQPQGLQHQQQQFGLTQQHGQGRRQNIVQPNPASQNNNRMMLDMLLLNQIAQSNRMNTLAFIMAN
Protein: Resiniferatoxin-binding, phosphotriesterase-related protein (Q3IVY4)
Organism: Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides)
Interaction partners:
- Cytoplasmic protein
- Monosaccharide ABC transporter substrate-binding protein, CUT2 family
- Monosaccharide ABC transporter ATP-binding protein, CUT2 family
- Adenosine deaminase
- Uncharacterized protein
- Monosaccharide ABC transporter membrane protein, CUT2 family
- BtpA protein
- Transcriptional regulator, LacI family
- Triosephosphate isomerase
Sequence:
MSELSPCHVRSGRIMTVDGPIPSSALGHTLMHEHLQNDCRCWWNPPQEPERQYLAEAPISIEILSELRQDPFVNKHNIALDDLDLAIAEVKQFAAVGGRSIVDPTCRGIGRDPVKLRRISAETGVQVVMGAGYYLASSMPETAARLSADDIADEIVAEALEGTDGTDARIGLIGEIGVSSDFTAEEEKSLRGAARAQVRTGLPLMVHLPGWFRLAHRVLDLVEEEGADLRHTVLCHMNPSHMDPVYQATLAQRGAFLEFDMIGMDFFYADQGVQCPSDDEVARAILGLADHGYLDRILLSHDVFVKMMLTRYGGNGYAFVTKHFLPRLRRHGLDDAALETLMVTNPRRVFDASI
Protein: Hepatic sodium/bile acid cotransporter (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (NTCP) (Solute carrier family 10 member 1) (SLC10A1) (P26435)
Organism: Rattus norvegicus (Rat)
Function: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q14973}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14973}.
Interaction partners:
- Solute carrier organic anion transporter family member 1B2
- Bile salt export pump
- Solute carrier organic anion transporter family member 1A1
- Cytochrome P450 7A1
- Bile acid-CoA:amino acid N-acyltransferase
- Solute carrier organic anion transporter family member 1A4
- Bile acid receptor
- Cytochrome P450 family 8 subfamily B member 1
- Nuclear receptor subfamily 0 group B member 2
- Solute carrier family 51 member A
Sequence:
MEVHNVSAPFNFSLPPGFGHRATDKALSIILVLMLLLIMLSLGCTMEFSKIKAHLWKPKGVIVALVAQFGIMPLAAFLLGKIFHLSNIEALAILICGCSPGGNLSNLFTLAMKGDMNLSIVMTTCSSFSALGMMPLLLYVYSKGIYDGDLKDKVPYKGIMISLVIVLIPCTIGIVLKSKRPHYVPYILKGGMIITFLLSVAVTALSVINVGNSIMFVMTPHLLATSSLMPFSGFLMGYILSALFQLNPSCRRTISMETGFQNIQLCSTILNVTFPPEVIGPLFFFPLLYMIFQLAEGLLIIIIFRCYEKIKPPKDQTKITYKAAATEDATPAALEKGTHNGNIPPLQPGPSPNGLNSGQMAN
Protein: Na+/H+ exchanger (Q9WUJ4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
QQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKIRKLTPGEMDEIREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESLRKDNSSNRERRASTSTSR
Protein: DNA-directed RNA polymerase II subunit rpb7 (RNA polymerase II subunit B7) (Q54P04)
Organism: Dictyostelium discoideum (Social amoeba)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit rpabc4
- DNA-directed RNA polymerase II subunit rpb11
- DNA-directed RNA polymerases I, II, and III subunit rpabc1
- DNA-directed RNA polymerase II subunit rpb4
- DNA-directed RNA polymerases I, II, and III subunit rpabc3
- DNA-directed RNA polymerase II subunit rpb3
- DNA-directed RNA polymerases I, II, and III subunit rpabc5
- DNA-directed RNA polymerase II subunit rpb2
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerases I, II, and III subunit rpabc2
Sequence:
MFFHLTLEKDLHMHPKHCGPNLFTIATQQLYSEVEGTCTGRYGFIITITSVDFLSKGKVLESSGYVVFNVKYKAIIFKPFKGEVLDAIVTKVTNLGFFAEAGPLSIFVSTQLIPSDMIFDAQSAVPCFVSEDGSSKISKDDEVRLQIKGTRVDATEIFAIGSIREDYLGVIG
Protein: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (Q960K8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGPIQRLVYTFGHRTCSQLPMIGGATISQTKPTTMALSVRQSSSSVLATESSNKGMIILNRPKALNAINLEMVRKIYKHLKKCEKSKSLVIIKGTGDKAFCAGGDVRALVEAGPTDESKSFFREEYSTNALIGNYKIPYIAIIDGITMGGGVGLSVHGKYRVASDRTLFAMPETAIGLFPDVGGSYFLPRLQGKLGLYLGLTGYRLRGADVYYSGIATHYCESSKIPDLETALLNCPDADDVPELLQKYHSPPEKPFSLQPVLEQINKNFSADSVEGILENLQNDGSEWAKKTLETLSKMSPTSMKVTFRQLELGSQLSLAQCLIMEYRLAVRHLERSDFKEGVRALLIDKDQKPQWQPTKLADVTEEHVQWFFRKLPDTEELKL
Protein: Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase) (O43704)
Organism: Homo sapiens (Human)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}.
Interaction partners:
- Carbohydrate sulfotransferase 6
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
- Heparan sulfate glucosamine 3-O-sulfotransferase 1
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
- Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
- Sulfotransferase 2A1
- Heparan sulfate glucosamine 3-O-sulfotransferase 3B1
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
- Carbohydrate sulfotransferase 5
Sequence:
MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDMILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLPKSFWENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNWWKKKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVNYTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI
Protein: Trafficking protein particle complex subunit 6B (TRAPP complex subunit 6B) (Q86SZ2)
Organism: Homo sapiens (Human)
Function: Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable).
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Interaction partners:
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit 3
- Trafficking protein particle complex subunit 4
- Trafficking protein particle complex subunit 8
- Trafficking protein particle complex subunit 2
- Trafficking protein particle complex subunit 1
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 11
- Trafficking protein particle complex subunit 9
- Trafficking protein particle complex subunit 12
Sequence:
MADEALFLLLHNEMVSGVYKSAEQGEVENGRCITKLENMGFRVGQGLIERFTKDTARFKDELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLTQMSAGKQYLEHASKYLAFTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKL
Protein: Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) (O43166)
Organism: Homo sapiens (Human)
Function: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity). {ECO:0000250}.
Interaction partners:
- Leucine zipper putative tumor suppressor 3
- Ras-related protein Rap-1A
- Ras-related protein Rap-1b
- Disks large homolog 4
- Leucine zipper putative tumor suppressor 2
- SH3 and multiple ankyrin repeat domains protein 3
- Leucine zipper putative tumor suppressor 1
Sequence:
MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAPVGPPRSEGSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSLKIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQVPSQVQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQHEYTEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQGTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETESHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSARSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKFHALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS
Protein: Enhancer of split mbeta protein (E(spl)mbeta) (HLH-mbeta) (Split locus enhancer protein mA) (Q01069)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. Part of the Notch signaling pathway.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Enhancer of split m3 protein
- Enhancer of split malpha protein
- Enhancer of split M2 protein
- Enhancer of split m7 protein
- Sphingosine-1-phosphate lyase
- Protein groucho
- Achaete-scute complex protein T4
Sequence:
MVLEMEMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSGPMWRPW
Protein: Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1) (Q9Z2Q6)
Organism: Mus musculus (Mouse)
Function: Filament-forming cytoskeletal GTPase (By similarity). Involved in cytokinesis (Potential). May play a role in platelet secretion.
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Septin-7
- Septin-8
- Septin-11
- Septin-6
- Neuronal-specific septin-3
- Septin-2
- E3 ubiquitin-protein ligase parkin
- Septin-4
- Septin-9
- Septin 12
Sequence:
MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERINQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNSECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKDRIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEELRRMQEMLQKMKQQMQDQ
Protein: Transmembrane protein 234 (B8A4M2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Zinc finger protein 185 with LIM domain.
- Transmembrane protein 63A.
- Osmosensitive cation channel TMEM63C
Sequence:
MVSTSEVFCLLLVAILWGGTNPFLKKGTEGIEEVQKKNKLLQFLAELKFLFLNFKYLVPFLLNQSGSLVFYFTLASTDLSLAVPVVNSLTFLFTLLMGKVLGEEFGGKGAIMGMLLIMCGVTVCVLSSVSETHGIGARNISET
Protein: Kunitz-type serine protease inhibitor LmKTT-1c (Delta-KTx 2.3) (P0DJ48)
Organism: Lychas mucronatus (Chinese swimming scorpion)
Function: Dual-function toxin that completely inhibits trypsin activity at a molar ratio of 1:1 (dissociation constant of 124 nM) and that inhibits mKv1.3/KCNA3 potassium channel currents (1 uM inhibits 50% of currents).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
KNKCQLPSDVGKGKASFTRYFYNEESGKCETFIYGGMGGNSNNFLTKEACCRECAQGSC
Protein: Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form] (Q9H7Z7)
Organism: Homo sapiens (Human)
Function: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:12835322}; Single-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12835322}. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region. {ECO:0000269|PubMed:12835322}.
Interaction partners:
- Prostaglandin E synthase 3
- Prostaglandin E synthase
- Prostaglandin G/H synthase 2
- Prostaglandin G/H synthase 1
- Prostacyclin synthase
- Prostaglandin-H2 D-isomerase
- Hematopoietic prostaglandin D synthase
- Carbonyl reductase 1])
- Carbonyl reductase 3
- Glutaredoxin-1
Sequence:
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH
Protein: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) (Q9BQC3)
Organism: Homo sapiens (Human)
Function: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).
Interaction partners:
- 2-
- Diphthine methyl ester synthase
- Diphthamide biosynthesis protein 3
- Elongation factor 2
- DnaJ homolog subfamily C member 24
- Diphthine methyltransferase
- U3 small nucleolar RNA-interacting protein 2
- Diphthine--ammonia ligase
- ATP-dependent DNA helicase DDX31
- Esterase OVCA2
Sequence:
MESMFSSPAEAALQRETGVPGLLTPLPDLDGVYELERVAGFVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPVAFVLRQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALEALATLLRPRYLDLLVSSPAFPQPVGSLSPEPMPLERFGRRFPLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLGWAPGQPFSSCCPDTGKTQDEGARAGRLRARRRYLVERARDARVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPEVDVFVLLACPLGALAPQLSGSFFQPILAPCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVALPPPESELWETPDVSLITGDLRPPPAWKSSNDHGSLALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIAIAYEDEGSG