wanglab/gogpt-training-data huggingface dataset:
Protein: Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) (P50454)
Organism: Homo sapiens (Human)
Function: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
Subcellular location: Endoplasmic reticulum lumen.
Interaction partners:
- Collagen alpha-1
- Peptidyl-prolyl cis-trans isomerase FKBP10
- Collagen alpha-1
- Prolyl 3-hydroxylase 1
- Cartilage-associated protein
- Collagen alpha-2
- Collagen alpha-2
- Collagen alpha-1
- Neutrophil collagenase
- Collagen alpha-2
Sequence:
MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL
Protein: Forkhead box protein E4 (FoxE4) (Xlens1) (Q9PTK2)
Organism: Xenopus laevis (African clawed frog)
Function: Probable transcription factor. Mediates lens formation in the embryo by promoting the proliferation of the specified lens ectoderm and suppressing its terminal differentiation.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Interaction partners:
Sequence:
MDSPDSVRVKCESKGSCSPEEGLNNGLPEEHNQASGGRRRKRPVQRGKPPYSYIALIAMAIANSPERKLTLGGIYKFIMERFPFYRENSKKWQNSIRHNLTLNDCFVKIPREPGHPGKGNYWTLDPAAEDMFDNGSFLRRRKRFKRTDITTYPGYMQNSSAFTPTPTGRASYPNSIYSSVGSGYNPQIHQTHHPAVVHQYYQSPGEAGQGQHRMFSIDSLINQQSLMQPSPGAELTHHSLGLNGNLGNMTNSCSVGDLSCFQTQSISPTGVGSLLNRSSNAVSSNLTYSYSSSPPHLPVPPASYSPNNSQLYGSTSRLAMRSGPCVDHTDQLLSLPGTQINGVCQYNNSSYMRQTHFASGLERYM
Protein: Importin-13 (Q9VEC5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Protein mago nashi
- Dorsal interacting protein 4
- RNA-binding protein 8A
- Eukaryotic translation initiation factor 4C
- GTP-binding nuclear protein Ran
- GTP-binding nuclear protein Ran-like
- D-Importin 7/RanBP7
- Eukaryotic translation initiation factor 5A
- Trifunctional purine biosynthetic protein adenosine-3
- Importin beta11
Sequence:
MEPIDIARLEEAVVSFYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLMKHWHEVPPENREELKQKILESIVRFAGGPKIVLNRLCISLGAYIVHMLGEWPGAIEEVINTFQNQRMPNVSADVQLWIMLEVLTAIPEEAQVIHTSVKRVVLRAEIAKRVQLVIHTVERYLKLQMNRVWDAEAYSNMNRAVKCVGTWIKNIGYTIEGCVTITAVLLEVVHKCYWPCIHAGDGCMTADENELAESCLKTMVNIIIQPDCHNYPKTAFVLIKMFLDSLSEITKTEWKRENDNEDIIVHIYMLFVSSVERHSTLLLSGITSADPELSILVHRIVQEILHCTDKPGIYPVEESCSTMALAFWYMLQDEVFAMSNDEQKHKCWEYIKPLYAHLTRILVRKSEQPDEKSLAKWSSDDLECFRCYRQDISDTFMYCYDVLNDYILEILAAMLDEAIADLQRHPTHWTKLEACIYSFQSVAEHFGGEEKRQIPRLMRVLAEIPYEKLNVKLLGTALETMGSYCNWLMENPAYIPPAINLLVRGLNSSMSAQATLGLKELCRDCQLQLKPYADPLLNACHASLNTGRMKNSDSVRLMFSIGKLMSLLRPEEIPKYLDIIVSPCFEELQAICQADSKTPAARIRTIFRLNMISTLFSSLNTDVDEQATDQPIVQPVLLVMQRTMPIFKRIAEMWVEEIDVLEAACSAMKHAITNLRSSFQPMLQDLCLFIVASFQTRCCAPTLEISKTAIVMFFKDEGCKPLMQQLLREFIQHSFKLFESTPEQNFSNISDTMETFFGCLTQIIKKIPQVLEDKTLAYDRLVFYAQRGMTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYTAMMCVGYLTPRSQVDKFADILLAMNRKYAAEMAVWMKSLMSTPNFPTQLITDADKTRYTALIIKEKVNKRLLQQHLSEMAMKTRGLTEKFQ
Protein: Pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit, putative (Q725S6)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Pyruvate ferredoxin/flavodoxin oxidoreductase family protein
- Pyruvate:ferredoxin oxidoreductase
- Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein
- Pyruvate ferredoxin oxidoreductase, alpha subunit
- Iron-sulfur cluster-binding protein
- Pyruvate ferredoxin oxidoreductase, gamma subunit, putative
- Pyruvate ferredoxin oxidoreductase, alpha subunit, putative
- Succinate--CoA ligase subunit alpha
- L-lactate dehydrogenase
- Pyruvate ferredoxin oxidoreductase, iron-sulfur binding subunit, putative
Sequence:
MPELLVDRATHYCPGCHHGVAHRLVAEVLTEMGVAEDTICVSSIGCSVFIYNYLAVDTVEAPHGRAPAVATGVKRARKDKIVFAYQGDGDLASIGLAEIMHAANRGERMTIVFVNNTVYGMTGGQMAPTTLVGQKTTTCPSGRCRDTEGLPMKMAEIIAGLGGVAYSARVSLDSVKHIRAAKKALRKAFDVQQNDLGFGFVEMLSACPTNWRMDAVKANKRIAEEMIPYFPLGVYKDVTEAEGVC
Protein: Guanylate cyclase D (EC 4.6.1.2) (A0A0U1RPR8)
Organism: Mus musculus (Mouse)
Function: Functions as an olfactory receptor activated by urine odorants, uroguanylin and guanylin and as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2). Has guanylate cyclase activity upon binding of the ligand (By similarity). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency. Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference.
Subcellular location: Cell projection, cilium membrane {ECO:0000269|PubMed:9096404}; Single-pass type I membrane protein.
Interaction partners:
- Guanylyl cyclase-activating protein 2
- Guanylyl cyclase-activating protein 1
- Neurocalcin-delta
- Retinal guanylyl cyclase 2
- Retinal guanylyl cyclase 1
- Bis
- Inosine triphosphate pyrophosphatase
- Aryl-hydrocarbon-interacting protein-like 1
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Sequence:
MAGLQQGCHFEGQNWTAPHWKTCLPCQGPWRLTVSHLKTVSSISVLSVVFWSVLLWADSLSLLAWARETFTLGVLGPWDCDPIFAQALPSIATQLAVDQVNQDASLLPGSQLDFKVLPTGCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFSWACEAPEGGGDLVPTLPSAADVLLSVMRHFGWARWAIVSSHQDIWVTTAQQLATAFRTHGLPIGLVTSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTLLHCAWEEGLTDGRLVFLPYDTLLFALPYGNRSYLVLDDHGPLQEAYDAVLTVSLESSPESHAFTATEMSGGATANLEPEQVSPLFGTIYDAVILLAHALNRSETHGAGLSGAHLGDHVRALDVAGFSQRIRTDGKGRRLAQYVILDTDGEGSQLVPTHILDTSTWQVQPLGKPIHFPGGSPPAHDASCWFDPNTLCIRGVQPLGSLLTLTIACVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTSQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGSARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSSRPQPAPEELLWTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIKPGDPWQDRINQEIRTGFAKARQGLAEPRKSGEAGPGP
Protein: Hyperpolarization-activated ion channel variant DMIH-A3B1C1 (Q56JH8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MTLHSDPSMQVHFDDVSLYGTPKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAEADDCKDDDMDLKENLLHGSESSIAEPVQTIREGLPRPRSGEFRALFEGNTP
Protein: Probable trehalose-phosphate phosphatase 1 (OsTPP1) (EC 3.1.3.12) (Trehalose 6-phosphate phosphatase) (Q75WV3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant improves abiotic stress tolerance.
Interaction partners:
- Probable trehalase
- Os05g0518600 protein
- Trehalose 6-phosphate phosphatase
- Trehalose 6-phosphate phosphatase
- Trehalose 6-phosphate phosphatase
- alpha,alpha-trehalose-phosphate synthase
- Os09g0376800 protein
- alpha,alpha-trehalose-phosphate synthase
- alpha,alpha-trehalose-phosphate synthase
- Os01g0730300 protein.
Sequence:
MDLSNSSPVITDPVAISQQLLGGLPSNLMQFSVMPGGYSSSGMNVGVSRLKIEEVLVNGLLDAMKSSSPRRRLNVAFGEDNSSEEEDPAYSAWMAKCPSALASFKQIVASAQGKKIAVFLDYDGTLSPIVDDPDKAVMSPVMRAAVRNVAKYFPTAIVSGRSRNKVFEFVKLKELYYAGSHGMDIMAPSANHEHSAEKSKQANLFQPAHDFLPMIDEVTKSLLQVVSGIEGATVENNKFCVSVHYRNVAEKDWKLVARLVNEVLEAFPRLKVTNGRMVLEVRPVIDWDKGKAVEFLLQSLGLNDSENVIPIYIGDDRTDEDAFKVLRQRNCGYGILVSQVPKETEAFYSLRDPSEVMEFLNFLVRWKKHSV
Protein: Zinc metallopeptidase, putative (Q388P7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Prohibitin
- Prohibitin
Sequence:
MSTASNTNSEYVRGLNDAYAHRSRTEDNWLRPSLGPLLWFGVPIALSWVYMRRQSPTGAKNNMFDSFMEQMMPIKKRQFRVEVKGTRFSDVIGIPEAKEEVRHYVEFLKNPNQFTRLGARLPKGCLLTGEPGTGKTLLAKAVAGEADVPFFSCSGSDFIELMGGSGPKRVRELFEEARGAAPAIIFIDEIDAIGSRAGKRGGSVSSEENRTINQLLAELDGLNSGSDVLIVMAATNFQDNIDKALLREGRFDRKINIEMPDKAARVEVFKHYLDRVCTGDPKGRTTDDEGQPLQVDDRISNLVLAKELADMTPGLSPATIATVVNEAALQSGIQEKKLVEKESFLEAVDNTLVGSKHRNRQSETSLRRTAIHETGHALTAWMLPTVKRVLKVSVVPRGQALGYTQRAGNEYHEYQTNATLLADMVVMLGGRAAEEALLGNPSAGAMDDLQRATDLALKQMMAFGMDADAGLLAYHPESTQAGRMFVNYSNKAQHLAEKEAMKLVSLSYQMAVDIIKNNTEKVEIVVGELLSKKELMSADLERLWGERPVTPTVEQLVGKLMDAQNQPQY
Protein: ATP synthase F(1) complex subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit) (P05630)
Organism: Bos taurus (Bovine)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular location: Mitochondrion. Mitochondrion inner membrane.
Interaction partners:
- ATP synthase lipid-binding protein
- Uncharacterized protein.
- ATP synthase F
- ATP synthase peripheral stalk subunit b, mitochondrial
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit F6, mitochondrial
- ATP synthase F
Sequence:
MLPSALLRRPGLGRLVRQVRLYAEAAAAQAPAAGPGQMSFTFASPTQVFFNSANVRQVDVPTQTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSVTVNADSSVQLLAEEAVTLDMLDLGAAKANLEKAQSELLGAADEATRAEIQIRIEANEALVKALE
Protein: Myoblast growth factor receptor egl-15 (EC 2.7.10.1) (Egg-laying defective protein 15) (Q10656)
Organism: Caenorhabditis elegans
Function: Receptor tyrosine kinase required for larval development. May phosphorylate adapter protein soc-1 which in turn may result in the recruitment and/or activation of phosphatase ptp-2. May activate the Ras/MAPK kinase signaling pathway which includes sem-5, sos-1, let-60/Ras, lin-45/Raf, mek-2 and mpk-1. Acts in the hypodermis to regulate axon growth and fluid homeostasis. Activates protein degradation in muscles. Probably following interaction with ligand let-756, regulates negatively membrane protrusion from body wall muscles during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. Regulates synaptic levels of nAChR subunit lev-1 in the nerve cord.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Protein let-756
- EGL-17
- Sex muscle abnormal protein 5
- Ras protein let-60
- RRM domain-containing protein
- IRS-type PTB domain-containing protein
- Glycoside hydrolase family 1 protein
- Glycoside hydrolase family 1 protein
- Twist-related protein
- Receptor-type tyrosine-protein phosphatase
Sequence:
MSYFLASCLGVGLLSTVSCSLQGLTSHYRENIPRFKHVANERYEVFLGDEIKFDCQTAASKISAFVEWYRNDKLLKNDQIDKDKIRKDNNRMMLHLKNIDVSDQGLWSCRVHNAYGQISRNFTVEVIDFCDYFLFPDIHHLNIPMECVCLWKYNKEAKRSDVNYAAVTGEVCSKYASRMINRARKPLPMIPCFGDHCKEFDTTPVSDFGLPGKPEDDPLVKRVVLKKDDVIVPVHDSEESPSESRTEFINADEKENKEDEEEDYSVSQPVAPDAGLTELNITAEEPPYFKSNDNIVLFNETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIVNRMRRPPIIVPNILANQSVNINDTATFHCKVVSDLLPHIIWVRINKINGSYSYYNNSAEEYMFNYTEMDTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLGMSMANATLTVNEFMAIHLLTGDEPKIDRWTTSDYIFTTILLFLLLAATLFGILFMVCKQTLHKKGFMDDTVGLVARKKRVVVSKRPMNEDNENSDDEPSPYQIQIIETPITKKEAARKQRKRMNSENTVLSEYEVDSDPVWEVERSKLSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWMLTMTNETIEGSQEFNDQFFSERSTASGPVSPMESFQKKRKHRPLSAPVNLPSEPQHTICDDYESNFSVEPPNDPNHLYCNDNMLKNHIITPETSQRIPSNNNSMSKPEF
Protein: L-aspartate/glutamate-specific racemase (L-Asp/Glu-specific racemase) (EC 5.1.1.13) (EC 5.1.1.3) (EcL-DER) (A0A140N890)
Organism: Escherichia coli (strain B / BL21-DE3)
Function: Exhibits racemase activity for both L-glutamate and L-aspartate, but has threefold higher activity for L-glutamate than L-aspartate. Cannot use D-glutamate or D-aspartate as substrate.
Interaction partners:
Sequence:
MKTIGLLGGMSWESTIPYYRLINEGIKQRLGGLHSAQVLLHSVDFHEIEECQRRGEWDKTGDILAEAALGLQRAGAEGIVLCTNTMHKVADAIESRCTLPFLHIADATGRAITGAGMTRVALLGTRYTMEQDFYRGRLTEQFSINCLIPEADERAKINQIIFEELCLGQFTEASRAYYAQVIARLAEQGAQGVIFGCTEIGLLVPEERSVLPVFDTAAIHAEDAVAFMLS
Protein: Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (A0A8I6G1H3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR038189}.
Interaction partners:
Sequence:
MSKPLTPSTYVRSLNVGILRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTCELLFDWGTTNCTVGDLVDLLIQIELFAPATLLLPDAVPQAVHSLPPREAATVAQAHRPCQEKNRTTVTPALAQKLEPSCELPDSSSPGHQSVEFSDTRFHSFSFYELKSITNDFDERPVSIGGNRMGEGGFGVVYKGCVNNTTVAVKKLGAMVEISTEELKQQFDQEIKVMAKCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPLSWHMRCKIARGAANGIRFLHENHHIHRDIKSANILLDQDFTAKISDFGLARASAKLAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLELITGLAAVDENREPQLLLDIKEEIEDKEKTIEDCTDEKMSDADPASVEAMYSVASQCLHEKKNRRPDIAKVQQLLQETSA
Protein: Stress-associated endoplasmic reticulum protein (A0A1D8PJJ9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU364120}; Single-pass membrane protein {ECO:0000256|RuleBase:RU364120}. Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU364120}; Single-pass membrane protein {ECO:0000256|RuleBase:RU364120}.
Interaction partners:
- ER lumen protein-retaining receptor
Sequence:
MALQTPKQRAANARFEKKNTNQWGKPKKENTKTEYPVSKSWLFVLLFLVCGGAILELIRLIF
Protein: Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial (EC 2.5.1.85) (All-trans-nonaprenyl-diphosphate synthase 3 (geranylgeranyl-diphosphate specific)) (Geranyl diphosphate synthase 1) (Trans-type polyprenyl pyrophosphate synthase) (AtPPPS) (Q5HZ00)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the supply of solanesyl diphosphate for ubiquinone-9 (UQ-9) biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:11069698, ECO:0000269|PubMed:21950843}. Mitochondrion {ECO:0000269|PubMed:21950843}.
Interaction partners:
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- Diphosphomevalonate decarboxylase MVD1, peroxisomal
- Diphosphomevalonate decarboxylase MVD2, peroxisomal
- Farnesyl pyrophosphate synthase 1, mitochondrial
- Farnesyl pyrophosphate synthase 2
- 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
- Isopentenyl phosphate kinase
- Hydroxymethylglutaryl-CoA synthase
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic
- 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic
Sequence:
MLFTRSVARISSKFLRNRSFYGSSQSLASHRFAIIPDQGHSCSDSPHKGYVCRTTYSLKSPVFGGFSHQLYHQSSSLVEEELDPFSLVADELSLLSNKLREMVLAEVPKLASAAEYFFKRGVQGKQFRSTILLLMATALNVRVPEALIGESTDIVTSELRVRQRGIAEITEMIHVASLLHDDVLDDADTRRGVGSLNVVMGNKMSVLAGDFLLSRACGALAALKNTEVVALLATAVEHLVTGETMEITSSTEQRYSMDYYMQKTYYKTASLISNSCKAVAVLTGQTAEVAVLAFEYGRNLGLAFQLIDDILDFTGTSASLGKGSLSDIRHGVITAPILFAMEEFPQLREVVDQVEKDPRNVDIALEYLGKSKGIQRARELAMEHANLAAAAIGSLPETDNEDVKRSRRALIDLTHRVITRNK
Protein: Eukaryotic aspartyl protease family protein (Q9FPD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAVDSPAGVIIIAAVLLLAATTLACGSDAVLKLERLIPPNHELGLTELRAFDSARHGRLLQSPVGGVVNFPVDGASDPFLVGLYYTKVKLGTPPREFNVQIDTGSDVLWVSCTSCNGCPKTSELQIQLSFFDPGVSSSASLVSCSDRRCYSNFQTESGCSPNNLCSYSFKYGDGSGTSGYYISDFMSFDTVITSTLAINSSAPFVFGCSNLQSGDLQRPRRAVDGIFGLGQGSLSVISQLAVQGLAPRVFSHCLKGDKSGGGIMVLGQIKRPDTVYTPLVPSQPHYNVNLQSIAVNGQILPIDPSVFTIATGDGTIIDTGTTLAYLPDEAYSPFIQAVANAVSQYGRPITYESYQCFEITAGDVDVFPQVSLSFAGGASMVLGPRAYLQIFSSSGSSIWCIGFQRMSHRRITILGDLVLKDKVVVYDLVRQRIGWAEYDCSLEVNVSASRGGRSKDVINTGQWRESGSESFNRSYYLLQLVVFLVHLFARFL
Protein: Iodothyronine deiodinase (Q6PBR8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGLLSVDLLVTLQILPGFFSNCLFFVLYDSIVLVKRVVSLLSCSGSTGEWQRMLTTAGVRSIWNSFLLDAYKQVKLGEAAPNSKVVKVTGINRCWSISGKTHNQCHLLDFESPDRPLVVNFGSATUPPFISQLPVFRRMVEEFSDVADFLLVYIDEAHPSDGWVGPPMENFSFEVRKHRNLEERMFAARTLLEHFSLPPQCQLVADCMDNNANIAYGVSYERVCIVQKNKIAYLGGKGPFFYNLKDVRRWLEKCYGK
Protein: Urease accessory protein UreG (P9WFE3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01389}.
Interaction partners:
- Urease accessory protein UreF
- Urease subunit alpha
- Urease subunit beta
- Possible formate hydrogenase HycE
- Urease subunit gamma
- Probable urease accessory protein UreD
- tRNA N6-adenosine threonylcarbamoyltransferase
- Putative esterase Rv1847
Sequence:
MATHSHPHSHTVPARPRRVRKPGEPLRIGVGGPVGSGKTALVAALCRQLRGELSLAVLTNDIYTTEDADFLRTHAVLPDDRIAAVQTGGCPHTAIRDDITANLDAIDELMAAHDALDLILVESGGDNLTATFSSGLVDAQIFVIDVAGGDKVPRKGGPGVTYSDLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQSLTEDPAASDVVAWVRSQLAADGV
Protein: Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (A0A060W139)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Ig-like domain-containing protein
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Endothelin-3
- Neuropeptide Y
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Motilin/ghrelin-associated peptide domain-containing protein
- Uncharacterized protein
- Endothelin-1
Sequence:
MGCDNLTNSNKTLPGRLPYTVQTSVPLTILVGILILLTVFGNVLVVIAVFTSRALRAPQNLFLVSLACADILVATLVMPFSLANELMGYWYFGQVWCEIYLALDVLFCTSSITHLCAISLDRYWSVTQAIEYNSKRTPRRIKCIVLFVWVLAAIISFPPLISMEKEGAKEEGPTCKINEEKWYIIFSSTASFFAPCVIMILVYVRIYQVAKNRTRAPPGERRRGNNNPDKSQRNREGGRDGVEEVNGIDVGEECSSSDGNENQCSIKMKLRKGKTKVSQVKLEDPSPKDYDAQQCVKVSRWKGRQNREKRFTFVLAVVMGVFVVCWFPFFFTYTLTAICESCCVPETLFNFFFWFGYCNSSLNPVIYTIFNNDFRRSFKKILCKKDRRGL
Protein: T-box transcription factor TBX3 (T-box protein 3) (P70324)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor involved in developmental processes (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity). Probably plays a role in limb pattern formation (By similarity). Required for mammary placode induction, and maintenance of the mammary buds during development. Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2. Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling. Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear. Acts as a negative regulator of PML function in cellular senescence (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Interaction partners:
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- Homeobox protein NANOG
- POU domain, class 5, transcription factor 1
- Transcription factor SOX-2
- Steroid hormone receptor ERR2
- Homeobox protein Nkx-2.5
- Krueppel-like factor 4
- Transcription factor GATA-4
- Sal-like protein 4
Sequence:
MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEDVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFEERHKKETSDESSSEQAAFNCFAQASSPAVSIVGTSNLKDLCPSEAESDAEAESKEEHGPEACDAAKISTTTAEEPGRDKGSPATRAQLFPAEPSRARDTARLDKASPDSRHSPATISSSTRVPGADERRSPGREGPVATKVDEARAIPAKDAFAPLSVQTDATAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPGQFAMGGAFSSMAAGMGPLLATVSGASTGVSGLESTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASTAAASSSVHRHPFLNLNSMRPRLRYSPYSIPVPVPDSSSLLATALPSMASAAGPLDGKAAALAASPASVAVDSGSELNSRSSTLSSGSVSLSPKLCSEKEAATSELQSIQRLVSGLEAKPDRSCSGSP
Protein: Protein trichome birefringence-like 10 (Q9LDG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- At5g50410
- Galactan beta-1,4-galactosyltransferase GALS2
- Protein FANTASTIC FOUR 4
- Germin-like protein subfamily 2 member 3
- Protein REDUCED WALL ACETYLATION 2
- Probable pectin methylesterase CGR3
- Probable pectin methylesterase CGR2
- Galactan beta-1,4-galactosyltransferase GALS3
- UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase 3
- Probable pectin methyltransferase QUA3
Sequence:
MSKNSNVEENGGAKPICEALRRFKRSRLVFEPSLGVLGFFLVGVCLVCSFFFFDYRSVAKSYGLSDKSERFVWLKFDNISSSSSSSSNSSKRVGFLEESGSGCDVFDGDWVWDESYPLYQSKDCRFLDEGFRCSDFGRSDLFYTQWRWQPRHCNLPRFDAKLMLEKLRDKRLVFVGDSIGRNQWESLLCLLSSAVKNESLIYEINGSPITKHKGFLVFKFEEYNCTVEYYRSPFLVPQSRPPIGSPGKVKTSLKLDTMDWTSSKWRDADVLVLNTGHWWNEGKTTRTGCYFQEGEEVKLKMNVDDAYKRALNTVVKWIHTELDSNKTQVFFRTFAPVHFRGGDWKTGGTCHMETLPEIGTSLASSETWEQLKILRDVLSHNSNRSETVKVKLLNITAMAAQRKDGHPSLYYLGPHGPAPLHRQDCSHWCLPGVPDTWNELFYALFMKQEAPSSSKRVEEANSTGNVTMS