wanglab/gogpt-training-data huggingface dataset:
Protein: F-box and leucine rich repeat protein 17 (A0A6E1XD66)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XIFSNLSLDERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSMSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVRVDYQVVCFLHISIVNSLMSYPLSFSISTPVYYILYIHFICIYAIIAMHCLPAFVN
Protein: SD06851p (Q8MSR0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSSKEQQAAGRDFKRNSNAYSSLPPTGTGAGCSGAALGSGTGTGKRARSKQHQLEHEQFGLSNSLSSESIRQACAYYDDELSDEDLIEIQQTPQAFHQQTKQPLQLQPISFRLGDELGDERSAFCGSQEMQQVPLSTPIKQAAETDEALCVLSELDAILDVHDVSQLNGTCSSGSVNSGSDDDKVEDYLMDLDNYLEEMDNALNREDSLIIIDGHTSLKREPRTRTLPLSRKKKSSKKKSEDQEAAQGDFQREHQLRKTFSCSLRPTSQIASSSGSLETSTEPVMDVWRRQSMRRALEQEDTKATVAMEREEDDIPTLLVELPPRRDAEMRRCFSQGDCQASVAPTGGSQMLTEAHIFDNLLQTNARASSEEPRPRQYGRRLEGPPTPVRSLILAQSRPQSAPTRVQMREPQLQDTPTHPIMSTCSELSSARSSRMPSPVSLPSDSSSSGSSSAEHDQEPDPVQTTTMCSASSTTPLEPLHQLQLLLREKCGFNSQWPHAGSRTLALIGCTLGVFNMCRFAVLTINFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAGPVSMWKISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVFPTAARSGYRWQEMAFPYRYDASNATGNLTQTVAEYFNVVVLQRLHLANHPDASGIRFHVNDRQLAFYLALIWAAVFLILCKGLKSLGKLAYIIYTLPLVALAVVTAKFVYVVDPSRIQNIFAASDFDDFLVNSNSWTAATQETFLTWGLLGASVIAITSRSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQILWQHGYVYVPGSFENPDCYTSIYSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIHVESGFQALRFISEIFPAVLSLASDSISWVWAAVAFATFAGFGLAQLCVMWKPISSALGNSTSSVLLSCVTGLLLSIPFATEMGISILYYVDFLLGGSWFIPIIWTAQIFGVFLIRGRPYNGDDLVNDLRLCGSMSAFLALSWNVLLPIGLITLSVVDYKASLSNQFYYWRGKSYFTYWSRKMGSLIQIGVLLVIPVTAIIQIYRYLAHGPPDILERIQLLYRPPEEGEEPRRPSARQTASQSRRNALGQTTEGGQHDAQNDAPPKYTPPPSYTTATGARLAKLLRQSIRRSVRRVLGDSSRTRPVLSLDAESASPAAPPDYLTILTNPAGSSFNADPSPASSSSPESIEIDQRPVGYAQRSQSLGRKLHRSGASTLERRPYTAEDVVTILRSSVRHRQSQGGGNLVTASTLPRPPTAAMSTHLEDASFRSIENLVLNAEPPDRTPGVELELELEAGQAEECARNNTSVI
Protein: Piercer of microtubule wall 1 protein (Pierce1) (UPF0691 protein C9orf116) (p53-induced expression in RB-null cells protein 1) (Q5BN46)
Organism: Homo sapiens (Human)
Function: Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Functions at the initial step of left-right asymmetry specification of the visceral organs.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q5BN45}.
Interaction partners:
- Cilia- and flagella-associated protein 90
- Tektin-1
- Piercer of microtubule wall 2 protein
- Cilia- and flagella-associated protein 53
- Cilia- and flagella-associated protein 161
- EF-hand domain-containing family member C2
- Meiosis-specific nuclear structural protein 1
- Ciliary microtubule inner protein 2B
- Tektin-3
- Protein Flattop
Sequence:
MAEECPRACAEPVAPKATAPPERTSDYYRVSADLPGRFNNPGWFRGYRTQKAVSVYRTSNQAYGSRAPTVHEMPKVFYPNSNKFSQQLAAGGMFRNNTLNVYLEKSIVTGPDNCITSCDRLNFHPSYNINRPSICD
Protein: ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) (Q9JLQ2)
Organism: Mus musculus (Mouse)
Function: GTPase-activating protein for ADP ribosylation factor family members, including ARF1.
Interaction partners:
- Rho guanine nucleotide exchange factor 7
- Paxillin
- G protein-coupled receptor kinase 4
- Rho guanine nucleotide exchange factor 6
- Serine/threonine-protein kinase PAK 3
- ARF GTPase-activating protein GIT1
- G protein-coupled receptor kinase 6
- Serine/threonine-protein kinase PAK 1
- G protein-coupled receptor kinase 5
- Ppfia1 protein,-interacting protein
Sequence:
MSKRLRSSDVCADCNGPDPSWASVNRGTFICDECCSVHRSLGRHISQVRHLKHTAWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCREDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLIEIQYELTDRLAFYLCGRKPDHKSGQHFLIPQRADSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSPLSRSKDNVELILRTVSTQHSTESQDNDQPDYDSVASDEDTDVETRASKANRQKLQTLQSENSSLRRQATASACQVQTGSDHKDTASHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASHPEESRTRLQPFPTHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTACDPEPDDTGSTRKGRQRSMLWQGDGLLPDTAEPHSVPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDTVRTSLRLLTSSAYRLQSECRKALPGDSSLPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENSS
Protein: Phospholipase D alpha 1 (CpPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D 1) (P86387)
Organism: Carica papaya (Papaya)
Function: Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond. Plays an important role in various cellular processes (By similarity).
Interaction partners:
Sequence:
MAHYLMHGTLHATVYEVDKLHSGGISGFFGKILANVEGTIGIGKGVTQLYATIDLERARVGRTRIIKDEPNNPKWYESFHIYCAHMASNVVFTVKDDNPIGATLIGRAYVPVEELIRGDQVDRWVEILDEDKNPIEGDSKIHVKLQFFDVKKDSNWNMGIKGARYLGVPYTFYSQRRGCRVSLYQDAHVPDGFIPKIPLAGGKYYEPHRCWEDVFDAITNARHLIYITGWSVYTEITLIRDSRRPKPGGDVTLGELLKQKASEGVKVLMLVWDDRTSVGLLKKDGLMATHDEETANYFQNTDVHCVLCPRNPDDGGSFVQGLQISTMFTHHQKIVVVDGEMPSGESQMRRIVSFVGGIDLCDGRYDTPFHSLFRTLDTAHHDDFHQPNFAGSSITKGGPREPWHDIHSRLEGPVAWDVLFNFEQRWRQQGGKDVLVNLRELDNIIIPPSPVMFPDDHETWNVQLFRSIDGGAAFGFPETPEEAARAGLVSGKDNIIDRSIQDAYINAIRRAKNFIYIENQYFLGSSFDWSSDDIKREDINALHLIPKELSLKIVSKIERGERFTVYVVVPMWPEGVPESASVQAILDWQRRTMEMMYKDIIQALRAKDREEDPRNYLTFFCLGNREVKKSGEYEPSERPEDDSDYIRAQEARRFMIYVHTKMMIVDDEYIIVGSANINQRSMDGARDSEIAMGAYQPYHLTINQPARGQIHGFRMALWYEHLGMLDDTFLEPENIECVQKVNRVAGKYWDLYASELLEHDLPGHLLRYPIGVSSEGDVTELPGTEFFPDTKARVLGAKSDYLPPILTT
Protein: Transcription factor bHLH123 (Basic helix-loop-helix protein 123) (AtbHLH123) (bHLH 123) (Transcription factor EN 63) (bHLH transcription factor bHLH123) (Q8GXT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Agamous-like MADS-box protein AGL93
- At5g25170
- Putative L-type lectin-domain containing receptor kinase V.1
- Putative transcription factor bHLH041
- Myb family transcription factor PHL6
- Transcription factor bHLH137
- Transcription factor bHLH143
- Transcription factor bHLH36
- Transcription factor bHLH144
Sequence:
MGDHHDFINSGSWWKVSSSSSPSSSSSMRASSIESGGSAVFHDKLHHHSLATDHHLQMIGLGLSSQSPVDQWNQSLLRGDSKAETSFGVMLQENLNLDATSNANANTTSSTSSYQLQESDSSHHHQALWRDPQSDFKPQILTSGGNRGFFLDHQFSPHGSSSTDSSTVTCQGFAVDNSSNAMYAATTTTPNSSSGMFHHQQAGGFGSSDQQPSRNHQQSSLGYSQFGSSTGNYDQMASALPSTWFLRSSPPPKPHSPLRFSNNATFWNPAAAGNAGAPPPHDASSNFFPALQPPQIHPQSFDEQPKNISEIRDSSSNEVKRGGNDHQPAAKRAKSEAASPSPAFKRKEKMGDRIAALQQLVSPFGKTDAASVLSEAIEYIKFLHQQVSALSNPYMKSGASLQHQQSDHSTELEVSEEPDLRSRGLCLVPVSSTFPVTHDTTVDFWTPTFGGTFR
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAM-TS 10) (ADAM-TS10) (ADAMTS-10) (EC 3.4.24.-) (Q9H324)
Organism: Homo sapiens (Human)
Function: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:21402694}.
Interaction partners:
- Fibrillin-1
- Latent-transforming growth factor beta-binding protein 1
- Latent-transforming growth factor beta-binding protein 2
- Fibrillin-2
- Latent-transforming growth factor beta-binding protein 3
Sequence:
MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCHGH
Protein: PHD finger family protein (F4KBB1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Calcium-binding EF hand family protein
- Calcium-binding EF hand family protein
- Calcium-binding EF-hand family protein
- WD-40 repeat-containing protein MSI3
- Calcium-binding EF-hand family protein
- PHD-finger and DNA binding domain-containing protein
- DDT domain-containing protein
- Homeobox-DDT domain protein RLT1
- Uncharacterized protein At5g25580
- DDT domain-containing protein PTM
Sequence:
MEGKVAKPRGRPRKRPRPEDLNGVSNRGKRPVFEVKVAVPRSLLGRYVLKDVDDSGVFLGKIVSYNTGLYRVEYEDGDFEDLETCYLRQLIIGDSYFDDELRARRSKLDDFILKKDEKKKTDCLKNKGVEVPTCNSPSSVAEVESGYSSCGLPECEDDIDPDFESMSPLVPPVELPSSSGTIGIPEEAVVYLLSVYGFLRSFSVQLYICPFGLDDFVGALNFLGPNSLLDAVHVALMRALKGHLERLSSEGSEVASKCLRCIDWSLLDALTWPVYLVQYFAAMGHASGPLWRFFNEFVVEKEYCSSPVVMKLKILQILCDDVFDVADLRAEIDNREESEVGFDTDGVTAELPENGPRRVHPRFAKTSASKEKELSEFVAVNHGISSLSDSKNWSSRYTDGGPNGDSPDLDANSDECRLCGMDGTLLCCDGCPLAYHSRCIGVVKMYIPDGPWYCPECTIKKMGPTVVYKTSLRGAVYFGVDPHGRLFLGTCNLLLVLKINVHADADIKYYNVTDIPKVVLVLLSATNHRLEYLYICKAISQYWDLPGGVISYLRTVETDLSHMQKEGGDEVSDIGEPDSANSSSGNLIQNAVRLHPSASGYTGGPVLARSSGAQEKNLVAVSTQKGLSFKPHSYINHYTNGELAASAAATLAILMSEETHEPDLHKFSNAKKAASSNILLQMKAFSIVASSFFWPSPDKKEITRERCGWCHSCKLTSASRRGCMLNAAVTGATKSAMKIYSGLFPLKNGEGVLSRIAAYALYLEESLRGLIAGPFLSESLRYQWRKKLEEASTCKAMKALLLELEENICSIALSSDWLKLMDDWLIELSIFQSAPVTVGATQKRRPGRRKQRNQAENTAQGSDDDSFTWWRGGKLSKIILLKAVLSKPKIKKAAWQGGTKKFPEFNYGDGSYIPKRSRRSIWKAAVESSKNISQLALQVRYLDMNIRWSELVRPEQNVQDVKGPETEATIFRNASICVKKIIDNKVRYGVVFGNQKHLPSRVMKNVIEVEKSEDRNEKYWFHEARVPLYLIKEYEESLHRVVHIPFIKKPSRKISKLQKRQLKASRANIFSYLASRRDNTEKCSCASCHLDVFLRDSITCSTCQGFCHKECTMSSQHTTGQLEILVTCKRCYLARARSQININHRQPTTPSVLINGQLQNAATSNTKTQIKRLNQQLPSSKTGDNASGVKQITPDFNLAPKSKHKTLSWGVIWRKKNLADTGVSFRHENVMLAGRSDQPNLQPVCWICKLPYNPGLTYIHCTSCDMWYHIEAVKLEESKIPEVVGFKCCRCRRIRSPDCPYMDPKLKEQKQMKQVFFRRQKHGQGNTGIDSDSERMSEPKDSLPSTPSFLSEDTFVPEDDPLLVSVSKVEQITPNSLDVEWNEDGCVPGPQKLQVRRPVKREDTDGNNNLSYTEFTMHPESMPVVKPEMEPTFPVMEWDASGNSNNMNEGELMFDYEDMEFEPQTYFSLTELLTTDDSGQCDGYGDDKDASGITDNPNPQVEAMEQCTSFLYENTIPCQICKHVEPGPDLTCQTCNMTIHSHCSPWEEESTCIGGSWRCGRCREWL
Protein: Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (P56520)
Organism: Gallus gallus (Chicken)
Function: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Also functions as deacetylase for non-histone targets. In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O15379}. Chromosome {ECO:0000250|UniProtKB:O15379}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O15379}.
Interaction partners:
- Nuclear receptor corepressor 2.
- Uncharacterized protein.
- Peroxisome proliferator-activated receptor gamma
- Uncharacterized protein.
- AT-rich interaction domain 4B.
- ARID domain-containing protein.
- Paired amphipathic helix protein Sin3a
- SIN3 transcription regulator family member B
- Transducin beta like 1X receptor 1
- MRG domain-containing protein.
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPNNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYALNVPLRDGIDDQSYKHLFQPVINQVVDYYQPTCIVLQCGADSLGRDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVDEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPSDLLSYDRTDEPDPEERGSEENYSRPEAANEFYDGDHDNDKESDVEI
Protein: Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) (Q8CHV6)
Organism: Mus musculus (Mouse)
Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (By similarity). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:16299514}. Chromosome {ECO:0000269|PubMed:16299514}.
Interaction partners:
- Transcriptional adapter 3
- SAGA-associated factor 29
- SPT3, SAGA and STAGA complex component
- Transformation/transcription domain-associated protein
- Transcription factor SPT20 homolog
- Transcription initiation factor TFIID subunit 12
- Histone acetyltransferase KAT2A
- Transcriptional adapter 1
- Histone acetyltransferase KAT2B
- Transcription initiation factor TFIID subunit 10
Sequence:
MDRLGSFSNDPSDKPPCRGCSSYLTEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLFASTLLNLKQAEAAKAADTAIPFHSADDPPRPAFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLVNLRKFRLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSPSVLMASNSGRRSAPPLNLTGLPGTEKLNEKEKELCQVVRLVPGAYLEYKSALLNECHKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYITKA
Protein: Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (PC12-PTP1) (Protein-tyrosine phosphatase PCPTP1) (Tyrosine phosphatase CBPTP) (O08617)
Organism: Rattus norvegicus (Rat)
Function: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).
Subcellular location: [Isoform 3]: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- mitogen-activated protein kinase
- Mitogen-activated protein kinase 13
- Mitogen-activated protein kinase 12
- Tyrosine-protein phosphatase non-receptor type 5
- Dual specificity protein phosphatase
- Tyrosine-protein phosphatase non-receptor type 7
- Mitogen-activated protein kinase 10
Sequence:
MRRAVGFPALCLLLNLHAAGCFSRNNDHFLAIRQKKSWKPMFIYDHSQDIKKSLDIAQEAYKHNYPAPSEVQISKRHQIVDSAFPRPAYDPSLNLLAASGQDLEIENLPIPAANVIVVTLQMDIDKLNITLLRIFRQGVAAALGLLPQQVHINRLIEKKSQIELFVSPGNRKPGEPQALQAEEVLRSLNVDVLRQSLPQFGSIDVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFIIIVTCLMIIYRLKERLQLSFRQDKEKNQEIHLSPIALQQAQSEAKAAHSMVQPDQAPKVLNVVVDPQGQCTPEIRNTASTSVCPSPFRMKPIGLQERRGSNVSLTLDMSSLGNVEPFVAVSTPREKVAMEYLQSASRVLTSPQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNITDPLSTYINANYIRGYSGKEKAFIATQGPMINTVNDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVIGVNECDNYTIRNLVLKRGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASEGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRVDRGGMVQTSEQYEFVHHALCLFESRLSPETVQ
Protein: Forkhead transcription factor HCM1 (High-copy suppressor of calmodulin protein 1) (P25364)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor regulating the cell cycle specific transcription of a spindle pole body (SPB) calmodulin binding protein SPC110. Required for full induction of SPC110 transcription in late G1. Binds to DNA consensus sequence 5'-[AT]AA[TC]AAACAA[AT]-3'. Dosage dependent suppressor of calmodulin mutants which have specific defects in SPB assembly.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Homeobox protein YHP1
- Nuclear division defective protein 1
- Cyclin-dependent kinase 1
- Homeobox protein YOX1
- Fork head protein homolog 1
- Mitotic spindle checkpoint component MAD2
- Protein GZF3
- mRNA cap guanine-N
- Fork head protein homolog 2
- Regulatory protein SWI4
Sequence:
MMNEDISIIDGHNSFLTEKSTVLLTQAKRTLEDEKEMITPPSSTVRKTMKEVNKRPSHPLSPDHSSPIAPSKAKRQRSDTCARSNGNLTLEEILQSLERRRINGELAKKPPYSYATLICLAILQSQEGKLTLSQIYHWIHVHFPYYKQKDASWQNSIRHNLSLNDAFIKTEKSCDGKGHFWEVRPGAETKFFKGENRGYEFVKDSLQDIGKYFEIDSTLDELEQVESGEGNDDLPDEEEREEAGKFPSIEIQLNSSPILRVSQLHHIPQLKTDNSVLNPHENLESMRNMIENDVNNIDSLEPPYVMKKYHTSLGLPSLVNAKDHFQAGVKNNNITQANRFNTLPITSAKSPQNFRKYFTSFNSNFEDLSPLRSNVGAGSLLDPLPYSPLKLYDQKNLALMSKPQSQQSYSNSQLPPPPSSHGSDLLKTPKMRHSDGLEKTPSRLISTPKDGNSILRKWQTPSHLFEDLYCSPLFRAIETPIRYITTPGGTLETQISPRKSSAPDVLTSATNSKFASSGLFGVDVYSVWKRATEKISDGNNTTDSNQKHHPYHNHPSNDSGNEKN
Protein: Uncharacterized protein (Q581Q8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
Sequence:
MDTECLRARHSECIDLASVQLRRQLMDSGIPFTEAEIAALPARFVELLISRLEMFRQREVETRAAVDKCRRETEVEEMRFEQLREATERVQGEKRIISSKISAAVSEYMREDKLEKEKQRERHNELQEVFRQVEKKEAEHRREIIEMERLRKMLKKVTK
Protein: Prostaglandin E receptor 2 (Subtype EP2)-like (Prostaglandin E receptor 2A (subtype EP2)) (Ptger2l protein) (Q6PFT8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MGTENGTCIDSVNVEQNGGPAISALMFAAGAIGNVLALVLLEFRRRKEKNRQRQSLFHLLVTTLVITDLTGTCLTSPVVQTAYLTNTTLVGMSKTHAVCEYFGFAMTFLSLATLSILLAMALERCISIGYPYHYGRHITKRCGYITIPCIYLACFLFCLMPFAGFGKYVQYCPGTWCFIAMNSEEIEDRAYANVYATVMLFIMIIIVVCNCFVVYHLVLMYRRRKMNRGSVQTRSKRNRRYFSWAEEVEHLILLVFMTVIFVICFLPLIVRFIVCDCNERK
Protein: Histocompatibility (minor) 13 (Hm13 protein) (Minor histocompatibility antigen H13 (EC 3.4.99.-)) (Signal peptide peptidase) (Q6IQA7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|ARBA:ARBA00004366}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004366}; Lumenal side {ECO:0000256|ARBA:ARBA00004366}.
Interaction partners:
- E3 ubiquitin-protein ligase RNF139
- Derlin
- Abhydrolase domain-containing 16A.
- Translocon-associated protein subunit beta
- Heme oxygenase
- Endoplasmin
Sequence:
MADVEQTAPAPDGSSNGSDLVNGTAGRFVSSAEGTALAYGSLLLMALLPIFFGALRSVGCSKSKGSSDMPETITSRDAARFPIIASCTLFGLYLFFKVFSQEYVNMLLSMYFFVLGILALSHTMSPFMCRVFPANLSNKQYQLLFTQGSGESKEEIVNYEFDTKDLICLCISSVVGVWYVLKKHWIANNLFGLAFALNGVELLHLNNVSTGCILLGGLFVYDVFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLGASNFAMLGLGDIVIPGIFIALLLRFDVSLKKNTRTYFYTSFLAYIFGLGLTIFVMHTFKHAQPALLYLVPACVGFPVLVALVKGELTEMFRYEEETPSKEETTESEKDK
Protein: ANTHER INDEHISCENCE1 (Q6T804)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MPRLMPEDASLLLDHVVGDPSVPAAAANAALAALPFPSRPTPRLLRASLLRRLAADPVSAAALDSLQLLASLPSSPSPAAPAAAAAAAAHLAVAAYLAVSAPDFDAAAGALFGRPGGRARRAVEEGGAAALASDEADAVADQFEAAVGNSFSQTVLRGLWGDRAAAEERVRELLAVEWAAIGQSRLEMAAERIVGDGAIETWRAADEVTRAKYRLLAGEQRAREIEGKLGETIPQGNQISTPEVHKVMDALKSSCANLHSVVEDPLPAAKAAADEVLAARMDKAVDLNAGEVSNQPTACDIAGPSAPADNLDAPRKGTAASLMDWNPTARTFQWEDSPDPDGSRSPIHRPQLPSPRRTTFSPLQPADNKAKRRKARKWCALEEETLRKGVEQYGNGNWKDILTNNPDVFIGRKAMDLKDKWRNMMR
Protein: Mitotic arrest deficient 2 like 2 (B1AK44)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTTLTRQDLNFGQVVADVLCEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSIRWAAPAPRPLAGISSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKGS
Protein: GH09868p (RH39704p) (TAR DNA-binding protein-43 homolog, isoform B) (TAR DNA-binding protein-43 homolog, isoform C) (TAR DNA-binding protein-43 homolog, isoform D) (TAR DNA-binding protein-43 homolog, isoform E) (TAR DNA-binding protein-43 homolog, isoform F) (Q8SXP8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Dorsal interacting protein 4
- Uncharacterized protein, isoform B
- Homeobox protein goosecoid
- IP10578p
- Superoxide dismutase
- Regulatory protein zeste
- Ribonuclease 3
- Huntingtin, isoform A
- Endoribonuclease Dcr-2
- Transitional endoplasmic reticulum ATPase TER94
Sequence:
MDFVQVSEEEGDEPIELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVESGWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVKVPNSKGMGHQVPCKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDPDVAQSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSGGNTNRQDGGSQYNSRQSNFHGMNQPHNGNVGGSNGWMNRGHLDMPNLQALGINSQGSSSSNQGQNMSNQSMLNLNSLPINPALVAAALNQWSLVGNQLQNQNQDQQGGNFLSWMAQNGGHNNANNFGGRKGPNNPNNNPAANGIKTDNSEPQNGNTGWSNQSSGSQNAAEKSNFL
Protein: General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) (P41541)
Organism: Bos taurus (Bovine)
Function: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
Subcellular location: Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Note=Recycles between the cytosol and the Golgi apparatus during interphase.
Interaction partners:
- Syntaxin-5
- Golgi SNAP receptor complex member 2
- BET1 homolog
- Golgi SNAP receptor complex member 1
- Golgin B1
- BET1-like protein
- small monomeric GTPase
- Ras-related protein Rab-1B
- Sec1 family domain-containing protein 1
- Coatomer subunit beta
Sequence:
MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNDEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIITEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPNNPPGATSSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNTVSAGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLETYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDSIVTHYKNMIREQDLQLEELKQQISTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKVQLGKDSQHQGPYTDGAQMNGVQPEEISRLREEIEELKSNRELLQSQLAEKDSLIENLKSSQLSPGTNEQSSATAGDSEQIAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSAPVPGESETVIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQNEKNKLEVDITDSKKEQDDLLVLLADQDQKIFSLKNKLKELGHPVEEEDELESGDQDDEDDEDEDDGKEQGHI