wanglab/gogpt-training-data huggingface dataset:
Protein: Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) (P39053)
Organism: Mus musculus (Mouse)
Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q05193}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q05193}. Cytoplasmic vesicle {ECO:0000269|PubMed:19781630}. Presynapse {ECO:0000250|UniProtKB:P21575}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250|UniProtKB:Q08DF4}. Note=Associated to the membrane in a helical polymer shape in a GTP bound state. Transiently recruited to endocytic clathrin-coated pits (CCPs) at a late stage of clathrin-coated vesicle (CCV) formation. {ECO:0000250|UniProtKB:Q05193}.
Interaction partners:
- Dynamin-3
- Amphiphysin
- Myc box-dependent-interacting protein 1
- Mitochondrial fission 1 protein
- Src substrate cortactin
- Dynamin-2
- Hematopoietic lineage cell-specific protein
- Endophilin-A1
- Protein kinase C and casein kinase substrate in neurons protein 1
- Intersectin-1
Sequence:
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNSTTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKIAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVDEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSLGAWRLNSPQGKHENRAGKARL
Protein: Heat stress transcription factor A-2 (AtHsfA2) (AtHsf-04) (O80982)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Seems to be involved in other environmental stress responses. Activates ascorbate peroxidase 2 (APX2) in addition to several heat shock protein (HSPs). Binds to the promoter of SGIP1 and activates its expression in heat acclimated plants. Involved in the mechanisms necessary for quick response to heat and subsequent heritable transgenerational memory of heat acclimation (global warming) such as early flowering and attenuated immunity; this process includes epigenetic regulation as well as post-transcriptional gene silencing (PTGS). In response to heat, HSFA2 is activated and promotes the expression of REF6 which in turn derepresses HSFA2, thus establishing an heritable feedback loop able to trigger SGIP1 and subsequent SGIP1-mediated SGS3 degradation; this prevents the biosynthesis of trans-acting siRNA (tasiRNA) and leads to the release of HTT5, which drives early flowering but attenuates immunity.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:20521085}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:20521085}.
Interaction partners:
- Heat shock protein 90-1
- Heat shock 70 kDa protein 4
- Chaperone protein ClpB1
- Multiprotein-bridging factor 1c
- Peptidyl-prolyl cis-trans isomerase FKBP62
- Heat shock 70 kDa protein 5
- Protein HEAT-STRESS-ASSOCIATED 32
- L-ascorbate peroxidase 2, cytosolic
- Heat shock protein 21, chloroplastic
- Dehydration-responsive element-binding protein 2A
Sequence:
MEELKVEMEEETVTFTGSVAASSSVGSSSSPRPMEGLNETGPPPFLTKTYEMVEDPATDTVVSWSNGRNSFVVWDSHKFSTTLLPRYFKHSNFSSFIRQLNTYGFRKIDPDRWEFANEGFLAGQKHLLKNIKRRRNMGLQNVNQQGSGMSCVEVGQYGFDGEVERLKRDHGVLVAEVVRLRQQQHSSKSQVAAMEQRLLVTEKRQQQMMTFLAKALNNPNFVQQFAVMSKEKKSLFGLDVGRKRRLTSTPSLGTMEENLLHDQEFDRMKDDMEMLFAAAIDDEANNSMPTKEEQCLEAMNVMMRDGNLEAALDVKVEDLVGSPLDWDSQDLHDMVDQMGFLGSEP
Protein: Coiled-coil domain-containing protein 13 (A0A3B3IRZ5)
Organism: Homo sapiens (Human)
Interaction partners:
- Partner and localizer of BRCA2
- Acyl carrier protein, mitochondrial
- Beta-alanine-activating enzyme
Sequence:
MRKIRDQNSFEKLKRHHSYPLGRMAADESSQNTLRLQFKAMQEMQHKRLQKQMEKKREKELSLKSRADDQEEPLEVSDGLSLLHAGEPNSKNSFEKRVLEDEIEHLRNELRETVDENGRLYKLLKERDFEIKHLKKKIEEDRFAFTGTAGVAGDVVATKIVELSKKNRLLMAESEGAKTRVKQLTNRIQELERELQTALTRLSAKGATDAGAKPPRAQMGDRALLETPEVKALQDRLVATNLKMSDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKGVGEGSSGREVSPAYTQFLEDPGLTKSPASAGDHVGRLGSSRSVTSLGHTLVESALTRPSLPSPHRTSPRFSDSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKASASQRAAPRTKTGLPTSNNRHNPTGSEKKDPSFAQLSDVPVESQMEELTTRLAIQVEENEMLKAALGSALRGKEEDFRMYHEILGQVKSVFLQALRQQKTGKQ
Protein: UPF0303 protein YBR137W (P38276)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Small glutamine-rich tetratricopeptide repeat-containing protein 2
- Ubiquitin-like protein MDY2
- Golgi to ER traffic protein 4
- Heat shock protein 104
- Mitochondrial protein import protein MAS5
- Putative uncharacterized protein YDL026W
- Uncharacterized protein YDR249C
- ATPase GET3
Sequence:
MVVLDKKLLERLTSRKVPLEELEDMEKRCFLSTFTYQDAFDLGTYIRNAVKENFPEKPVAIDISLPNGHCLFRTVTYGGSALDNDFWIQRKKKTALRFGHSSFYMGCKKGDKTPEEKFFVDSKEYAFHGGAVLIQSERSDYPYACLTISGLKQEEDHLMAVSSLIAFANESLEEDLNLD
Protein: ERBB-3 BINDING PROTEIN 1 (StEBP1) (M1CZC0)
Organism: Solanum tuberosum (Potato)
Function: Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Required for expression of cell cycle genes such as CYCD3-1, RNR2A and CDKB1-1. Promotes, in a dose- and auxin-dependent manner, organ growth by stimulating both cell proliferation and expansion, via the regulation of RBR1 levels.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96327, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Ribosome production factor 2 homolog
- Ribosome assembly factor mrt4
- Uncharacterized protein
- Pescadillo homolog
- Ribosomal protein L5
- Protein SDA1
- WD-repeat protein
- Integral membrane family protein
- GTP-binding family protein
- 60S ribosomal export protein NMD3
Sequence:
MSDDEREEKELDLTSPEVVTKYKSAAEIVNKALQLVLSECKPKAKIVDLCEKGDAFIKEQTGNMYKNVKKKIERGVAFPTCISVNNTVCHFSPLASDETVVEEGDILKIDMGCHIDGFIAVVGHTHVLHEGPVTGRAADVIAATNTAAEVALRLVRPGKKNSDVTEAIQKVAAAYDCKIVEGVLSHQMKQFVIDGNKVVLSVSNPDTRVDEAEFEENEVYSIDIVTSTGDGKPKLLDEKQTTIYKRAVDKSYNLKMKASRFIFSEISQKFPIMPFTARDLEEKRARLGLVECVNHELLQPYPVLHEKPGDLVAHIKFTVLLMPNGSDRVTSHALQELQPTKTTENEPEIKAWLALPTKTKKKGGGKKKKGKKGDKVEEASQAEPMEG
Protein: RNA-binding protein 8A (RNA-binding motif protein 8A) (Ribonucleoprotein RBM8A) (Q27W01)
Organism: Rattus norvegicus (Rat)
Function: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16275927}. Nucleus speckle {ECO:0000269|PubMed:16275927}. Cytoplasm {ECO:0000269|PubMed:16275927}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250|UniProtKB:Q9Y5S9}.
Interaction partners:
- Eukaryotic initiation factor 4A-III
- Protein mago nashi homolog
- Protein CASC3
- Regulator of nonsense transcripts 2
- Regulator of nonsense transcripts 1
- Mago homolog B, exon junction complex subunit
- PYM homolog 1, exon junction complex associated factor
- UPF3B, regulator of nonsense mediated mRNA decay
- Nonsense-mediated mRNA decay factor
- RCG43312)
Sequence:
MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGSEEGSRARMREDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNIHLNLDRRTGYLKGYTLVEYETYKEAQAAMEGLNGQDLMGQPISVDWCFVRGPPKGKRRGGRRRSRSPDRRRR
Protein: PRP8 protein homologue (Q38DR4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Pre-mRNA splicing factor, putative
- RNA helicase
- Small nuclear ribonucleoprotein SmD1
- Pre-mRNA-processing factor 19
- Uncharacterized protein
- Uncharacterized protein
- Pre-mRNA-splicing factor U5-Cwc21
- Uncharacterized protein
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MKSGGGISLTEDGFEHQYNGEGVTEKWSSGHRRQIAEWRNLNTKRYGYRATYQEAVAQKDEVPPEYLRKLVKDNGDLSGKRFNAERKLCVALLRYMPLALYKLLENMPMPWEEARYVNVVYHMRGVLTLVEDTPTAPEPLYLAQWGSIWTKMRSHKVELQQECGTFRRVISKGNENEPPIDFSDYIMDREPPPALYDDLDEEDAAAVLDWFYDPFPRLVHPNQIRGSRRPNGYYFTIDVIETLFRNAIPILPNLDDRNYYYLWDLKSFYAAKAMHIAIPRAPKFEAPSTIQEEEGEWTEFNDLRRVIHRDDPRKPRFTMLTERQIAFPFLYSDVVDGVTVAPYRYPAQIRVENEDPAVPCFSWNPSLNPIKAIQKRHSDPVGSSSVALCSAALRKSQWLGDEEPEDGCQPMSLMENFSPFFQELPLENVDTKSAMLLAFAPGPFNEFEGGMKRRVDIPVAEHWCRDPPSLLTNDTRDKILRSYTQLLKHHVAKNLRRDRQKERPKEEGGNQDEGGQPVRRLDELANLDFFHKTKIDWLEAGLQVMRQGHNMLVQLINVKSLPYVHINYNFEAKPTRTLTTKEIKKSRLGPAFHLIRELLGFMKQLIDMHTMYRLGKNDSIQLADAIQYLFSHLGRLTGVYRYKLRAMRQIKRSRDLKHVLYSKFNVGEVLRGPGCGFWAPSWRVWVFFLRGMTPLLQRYLGNLTDRVLRGREAKGKHDGKRITRQRVETDKDVNIKEAFRRELREMLPPDVRTEVIRTMDQHMNEAFRHWRAGLRWSVPGLAKPLTDLVNKYVKLRAEEYVRVTQYQRKRINEGDTVDKQAFMKNLGRLTRLKLMEEQNRQRSYMEGTDTDIITPEQATEIYRMMANWLSDRGFKKISFPKASRPAELRLLELALNRLRDQHNIANRLTQAQREEQARIEEAFNSPHETLSKIVDCLARVRRFKNVEVEYMDTFSSLYPIYNVVPSEKLVDSFLDQYLWYEAMDQQRLFPNWVKPSDLEPVPILVYKWCQGINDSPGIWDFDRDESVVLLHAKLEDDFYGNIDWNLFRPLLELIMDKSLAEYIVSRHDVVVEFKDMAYHCRKGMLRGFMFSSFLAQYWGLVIDVLLLGTQRSQEIAGPARRPNPFMSWMRDPLLATSHPIRGYCRYKNEVYVLLKYTKVEADDVRHRYLEETKNDPQKRAENASVYGFKNFKQWPRDARMRLFLNDVNLARAVIWEFRGRLPPGIADINESNALASVYSKDNPNLLFDMGGFSVRILPVVRTEDEVLENESTWNLQNTTTRDVTARAFLQVSPDDVNNIRNKARRAIMMVGSSTFQSIAAKWNALVTEIVPYYREAILGTDSLQQVLARAEHRMQSRIMMALNSRAKARFPPVIFYAPTDLGGLGMLSVGHSLIPARDLVYSKSTSTGVQFFYSGLTNADNIPIPNILQYYTPWETEVRESVKAWTEFNMRDREAKAAGTRLSIDDIEHIINKGVPRIRVLFSRHAKLFQFDKGFRCRMEFQRYLAGKYLKNWWFHQEHDGNICGGVLERYRVDTNIALGGVEAILEHSLFRGTGFPSWEGIEFNRAGGFENSKKDSKLAKQQRAGLANVPNRRFALWWCPTINRSDVQAGFETKIDTTGVFMCGKLETIKKSLIKIFSGSLWEKCHGAVVNDIASKLKDMMVELDAASVTLQQQHPQKSYTYTSSAPDIVMASTSRWPVTSKPTVLSDETGDEYRAHTTSKYWIDVQLRWGNYDSHNIAEYTRSRFYEYSSAKMYPFPAGIVVAIDLAYNCHSAFGYWVPRLKPLMMKLMTAIIRHNIALNTLRERMKRDLQLFSSAPTEAGLSVTNIAELFSEGMRTWIVDDSATYVTSEQPTAEGGRKFRSENGAVLIFEPATGNLKLSIVHKSVFAGQKRRTKLAREKAAEEIASWLRSVPASQRPGKLIVTRSRFRQTLHNMLILDYPNIIIGQSDLNLAVPMVLRHSRLADLRISATESKGWEFCLYDDWLRQFQPATCFNLLNLILRGYHVNLSRTRQTLEPDLHVEVHHSHFWPTYTREEWEAVSVRLQEMIIADAARRMNVSPNQFTEMEKKDILLGKKMTTVEIQEEEMKELEEMKRTKLVQEHTIDVVTKSGETAKKRVKAAFDFGNSTSASNWRARSLANATVFGEGTTVEIDHSGVTGSSDQLIFPQELLKILFPCFDVQAQFCAYLFGQTLPDSPNVKEVLCIMVPPQKSSAVEYTTPSCIPHDHPTLTENHLSLLGVLRCSGGEPSIHSRDVAIHGRLLACNEGLQTEGLTTVVVGVSQDGIGIRCYTTTREGISWALEEYSHALQREPTEVPPLHVIPARVTLSTELQGFFLVPTDNGWNHTFRGATWREDTTFDVRVDTPQFFFFATHRPDHFLNFARLTEEEATIDMADLENLMA
Protein: Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (P46062)
Organism: Mus musculus (Mouse)
Function: GTPase activator for the nuclear Ras-related regulatory proteins Rap1, Rsr1 and Ran in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression.
Subcellular location: Nucleus {ECO:0000269|PubMed:7799964}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96FS4}. Endomembrane system; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96FS4}. Note=Mostly localized in the perinuclear membraneous region. {ECO:0000250|UniProtKB:Q96FS4}.
Interaction partners:
- Afadin
- Ras-related protein Rap-1A
- Ras-related protein Rap-1b
- Ribosomal RNA processing protein 1 homolog B
Sequence:
MWAGGVGSPRRGMAPAPTDDLFARKLRQPARPPLTPNTFEPRPARGPLLRSGSDAGEVRPPTPASPRARAHSHEDASRPAATPTRLFTDPLALLGLPAEEPEPTFPPVLEPRWFAHYDVQSLLFDWAPRPRGTGSHTEANSGTLAEGQTTTSDLLLGAPGFVSELGGEGELGLGGPISPPVPPALPNAAVSVLEEPQTRTTTYSLEHADLGAGYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPSVSPRKLLEHVAPRLSPTCLRLGSASPKVPRQLLTLDEQVLSFQRKGGILYCRAGQGSEEEMYNNQEAGAAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHAPCTPHTSYRVAVSRTQDTPAFGPALPEGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRATPRSPGADVQAAGALMWGVRAAPGARVAAGAETSGPDDAEVPCLLGISAETLVLVAPRDGRVVFNCACRDVLAWTFSEHQLDLYHGRGEAITLRLDGAPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFITHVERFTFAETTGLRPGARLLRVCGQTLPKLGPETAAQMLRSAPKVCVTVLPPDESGRPRRSFSELYMLSLKEPSRRGGPEPVQDETGKLVILPPTKQLLHFCLKDSSSPPGPGDLTEERTEFLRTHNSLSSGSSLSDEAPVLPNTTPDLLLVTTANPSAPGTDRETPPSQDQSGSPSSHEDTSDSGPELRASILPRTLSLRNSISKIMSEAGSETLEDEWQSISEIASTCNTILESLSREGQPISESGDPKEALKCDSEPEPGSLSEKVSHLESMLWKLQEDLQREKADRAALEEEVRSLRHNNQRLLAESESAATRLLLASKHLGAPTTDLA
Protein: Triosephosphate isomerase (EC 5.3.1.1) (G8BB25)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- Phosphoglycerate kinase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glucose-6-phosphate isomerase
- Fructose-bisphosphate aldolase
- mRNA 3'-end-processing protein RNA14
- Transaldolase
- Transketolase
- phosphopyruvate hydratase
- phosphopyruvate hydratase
- Phosphoglycerate mutase
Sequence:
MARQFFVGGNFKANGTKASVKSIIDNLNKQDLPKDVQVVIAPPSLYLGLAVEENKQPTVEVGAQNVFNKGTGAYTGEIAAEQVVDLGAKWTLTGHSERRTIIKESDEFIAEKTKYAIDNGLSVILCIGETLDERKSGVTLEVCARQLDAVSKIIKDWSKIVVAYEPVWAIGTGLAATPDDAEETHKGIRDHLAKTIGQDQAEKVQILYGGSVNGKNAKEFRDKANIDGFLVGGASLKPEFVDIIKSRL
Protein: Plexin-B3 (Protein Plxnb3) (D3ZLH5)
Organism: Rattus norvegicus (Rat)
Function: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9ULL4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9ULL4}. Note=Colocalizes with RIT2/RIN at the plasma membrane. {ECO:0000250|UniProtKB:Q9ULL4}.
Interaction partners:
- Semaphorin-5A
- Semaphorin-4D
- Rho-related GTP-binding protein Rho6
- Semaphorin-4A
- Rho guanine nucleotide exchange factor 12
- Semaphorin-4C
- Hepatocyte growth factor receptor
- Semaphorin-4F
- Ras-related protein R-Ras
- Semaphorin-4B
Sequence:
MLTDFLQAPVMAPWSPFSLHLLLLFLLLLPLTRAHRFSVPNASFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRAQELVACGQVRQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPLPGRDLLLVARGLAGKLSAGVPPLTVRQLAGPQPFSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLGDVNLYSYVEVPLTCHGQGLIQAAFLAPDTLLGAFSAGTSQAQAALCAFPLADLDGSMEQARRLCYTTGGQGPNGMEEATVEYGVTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQPISAVAALQTDGHTIAFLGDTEGQLHKVFLNSSHGQVYHSQQVGPPGSAISPDLLVDNSGDYLYVLTAQQVDRILVAACPQFPNCTTCLQARDPLCGWCILQGRCTRRAECGRAVQPNQWLWSYEDNHCLHIQSLLPAQHPRQEHGQITLSVPGLPNLAMDEYFYCAFGDYNSLAQVEEHHVVCATPPQDRMPPNPPGSDHVTLPLALMFEDVVLAATTFSFYDCSAIQALEVAAPCRTCVSSLWRCHWCPQSSHCVYGERCPEGEKAVYSAQEVDILVRGPEACPQVKGLASPQLVPVGWESHVTLHIENLHYFRGLPALYYCWLELPGKLRKLPAFLEETSRNSGLIHCQAQQFHPSMSQWELPVPIYVTRGEIQRLDNTGDLHVTLYDCAMGHPDCSHCQAANGSLSCLWCGDGQPACRYGPLCPPGAVEQLCPIPSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPAPNGTSGPVQVAIKSRPPGISAQHFTYQDPVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNVSAFVGDQPCPIQEPVCPEAIICHTMPQMEPGEAVVFVVFGHVERKLLTTPFRYTANPQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLSVWLEDEFQVKALGVQAQDVNPRRSCGAPAADPQACIHLESGLLQCSTLCSVNSSSLLLCHSPAVPDGALPKRVFFALDNMQVDFASASGGQGFLYQPNPRLAPLSHEGITHPYRLKPGHVLDVEGEGLNLGISKEEVQVHIGDGKCLVKTLTLTHLYCEPPQQAPQPTNGSGTLPQFVVQMGNVRLALGPVQYEAEPMISTFPVEAQVGLGMGAAMLIAAVLLLTLMYRHKSKQALRDYQKVLVQLENLETGVGDQCRKEFTDLMTEMTDLTSDLEASGIPFLDYRTYAERAFFPGHVGCPLQPGLEGPGEEGRRVTVCQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASLLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYAFLKEVAGEPLYMLFRAIKYQVDKGPVDAVTGKAKRTLNDSHLLREDVEFRPLTLMALVGPGAGGAAGNSEVHRVPARVLDTDTITQVKEKVLDQIYKGTPFSQRPSVHSLDLEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDGATVVLIPQLHNGGTVSQSLEQTGCHSGENTPMLEDGEEGGVRLWHLVKATEETEGAKVRRSSLRERERERARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSMNRPVPIAVKYLFDFLDELAEKHGIEDPETLHIWKTNSLLLRFWVNALKNPQLIFDVRVSDNEDAILAVIAQTFIDSCMVSEHKVGRDSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALAELSGNYTSAPNCLEALRELYNHIHRYYDQIISALEEDPVAQKMQLACRLQQVAALVEYKVTDL
Protein: Netrin 4 (Q32SK8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MELTGRCVLLAALVMSVPHHACSGCVNRVCNPRMGNLAVGRPIQTISQCGSTSPEQFCMYRPDSCVLDCEICDASVSQHAHSPSSMTDSPFKQPLTWWQSAPGTAIETLQLDLEVEFYFTHLIIIFMSPRPAAMAIDRSRDFGQTWSLLMLFSHNCSEVSSLEDGQRCTAKYSSAEPCTNGEVPHSCPCPIADANAATPRYAISDLILKGGCLCHGHADQCVPTGGKHNSKTFGKHVVHGKCSCRHHTAGDHCERCHRLYNDRPWRAADGLTGEANQCVECKCNGHAESCHFDESVWLRSGQQHGGVCDCLHNTTGQHCQHCQSGFYRDPKKPSTAPDSCTPCMCNHVGSSYCKPDNGECVCKPGVAGRHCEQCMLGYWGLDEYGCKPCQCAGDCDPYTGDCMIRSESDDNSTAENHLFRTEELFSALSHPDKCICKQLALGNSKVFCNAKYAYAVKVRVLGAHDKGSHAEVDVKILKVLWDNTRLRLSRGSRTLYPESWMSRGCTCPVLFPGGLEYLVVGHEDVRKGRPVVNMKSIVKPWRASLSRKVHQLLKTKCS
Protein: Ninein (C9J066)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEGLNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQALLPEQRAVHADSYRRIGHL
Protein: Tryptase delta (EC 3.4.21.59) (Delta-tryptase) (HmMCP-3-like tryptase III) (Mast cell mMCP-7-like) (Tryptase-3) (Q9BZJ3)
Organism: Homo sapiens (Human)
Function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Subcellular location: Secreted {ECO:0000250}. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}.
Interaction partners:
- Tryptase alpha/beta-1
- Tryptase beta 2
Sequence:
MLLLAPQMLSLLLLALPVLASPAYVAPAPGQALQQTGIVGGQEAPRSKWPWQVSLRVRGPYWMHFCGGSLIHPQWVLTAAHCVEPDIKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYIIQTGADIALLELEEPVNISSHIHTVTLPPASETFPPGMPCWVTGWGDVDNNVHLPPPYPLKEVEVPVVENHLCNAEYHTGLHTGHSFQIVRDDMLCAGSENHDSCQGDSGGPLVCKVNGT
Protein: Oxalate oxidoreductase subunit alpha (OOR subunit alpha) (EC 1.2.7.10) (Q2RI41)
Organism: Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Function: Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel-dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria.
Interaction partners:
- Oxalate oxidoreductase subunit beta
- Oxalate oxidoreductase subunit delta
- Pyruvate:ferredoxin oxidoreductase
- Pyruvate ferredoxin oxidoreductase, beta subunit
- Ketoisovalerate ferredoxin oxidoreductase, beta subunit
- Pyruvate ferredoxin oxidoreductase, gamma subunit
- Pyruvate ferredoxin oxidoreductase, gamma subunit
- 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate
- 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate
- NADH dehydrogenase
Sequence:
MGKVRNISGCVAVAHGVRLADVDVICSYPIRPYTGIMSELARMVADGELDAEFVHGEGEHAQLSVVYGASAAGARVFTGSSGVGVTYAMEVYSPISGERLPVQMAIADRTLDPPGDFGEEHTDAECCRDQGWIQGWASTPQEALDNTLIYYRVGEDQRVLLPQYACLDGYFVSHILGPVDIPDEAQVKEFLPPYKNHHVLDPRKPQIIGPQIEPAMGPPLQYQRYQAVKGVHKVLEEACDEFARIFGRKYDPYLDEYLTDDAEVIIFGQGAHMETAKAVARRLRNLGEKVGVARLRTFRPFPTEQIKERLSKFKAIGVLDVSANFGISCSGGVLLSELRAALYDYGDKVKTVGFVAGLGGEVVTHDEFYRMFQKLKEIAKTGKVEQTSYWIPFEL
Protein: Acetyltransferase PA5475 (EC 2.3.1.-) (GCN5-related N-acetyltransferase) (GNAT) (Q9HT95)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers the antibiotic chloramphenicol.
Interaction partners:
- Pimeloyl-CoA synthetase
- Macro domain-containing protein
- ATP-grasp domain-containing protein
- Metallo-beta-lactamase domain-containing protein
- Bacteriohemerythrin
- DUF3079 domain-containing protein
- ADP-L-glycero-D-manno-heptose-6-epimerase
- Oxygen-independent coproporphyrinogen III oxidase
- alcohol dehydrogenase
- Hypothetical protein
Sequence:
MSNVQNASRSSAFAAVEGDHWVESLDDGRHVLIRPLREEDRERERQFINRLSPATRHFRFLGEIKEASPALLDQLMDIDYQQSMAFVALVHEDGELREVGISRYAACCEEGQCECAVTIADDYQGLGLDAVLMRHLIDVARRNGFRQMYSVDSAANRAMRDLCCALGFVGQRDPDDSTQVIHRLAL