Protein: Teneurin-a (Tena) (Tenascin-like protein) (Q9VYN8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with ten-m to organize neuromuscular synapses.
Subcellular location: Cell projection, axon. Presynaptic cell membrane. Synapse, synaptosome. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Localizes in the cell body and axon of neuronal cells. Localizes at neuromuscular junction.
Interaction partners:
- Latrophilin Cirl
- Teneurin-m
Sequence:
MTMKSMKYSDCDTIMDGYNPVPPPLPRRVPPVRNIYAEPFAHEPNHSSRLGGHPQQMPQSMSTGSNTIGHGGIDRGGVGLPMGAGTMPGGVGGGPGGVAGGGPQVGVGPPGSGNGGNCQISGSQPLVMPGFPLRNSHSAHAPHYSPYSPSRFHIDKRCQHRCSWKCLSIALIFVSVVLTAMLAYFAAVSSMKPNMDSTNCILVQDVKSQPHDLRGGLAKSNEKGVATAFPTEESIQTSTSDHGQNGHGLMNPSAGSGGSNSGIQQQLLLQQQQPHSINQPLTPLDATNTHLQDHHQLTYGGALPGGVGGIGMSGGGIMNGGLNGGLGGQLMQQPGGGLNGHHHQALQPQLGGVVELKEFNEAYHATIPAYQFWTLEFRNKHPAFIRFNFTLPWGAHFAVYSRRNVAPSVTQHDFVEFIKGGRLDSHLRHRRSSANATTTGQDMELYRQDKDQSAESAQDQDSEQDESRSFDSSESYDVETPLDTAKQHLQRIGKPQSHWVNKRSAGDGLPALDVDAMTVNVSLLQYLDTGLWFISVYNDELVAHSVSLLAEEAEGVSTTCPNDCSGRGSCYLGKCDCIDGYQGVDCSKSVCPVLCSAHGHYGGGVCHCEEGWKGAECDIPVGECEVPNCSSHGRCIEGECHCERGWKGPYCDQHDCLDPLCSGHGTCVAGQCYCKAGWQGEDCGTIDQQVYQCLPGCSEHGTYDLETGQCVCERHWTGPDCSQAVCSLDCGRNGVCESGKCRCNSGWTGNLCDQLPCDSRCSEHGQCKNGTCVCSQGWNGRHCTLPGCENGCSRHGQCTLENGEYRCDCIEGWAGRDCSIALELNCKDNIDNDGDGMTDCSDSECCSHPACSEHIMCLSSNDPVEVLLRKQPPSVTASFYQRVKFLIEENSVQSYAHMDEYSENRVSVMRGQVITPQGLGIVGIRVSVDRDSRFGFTLTRQGGWFDVLVNGGGAVTLQFQRSPFRPLTRTVFVPWNRIVVLPPVQMQLSDDDETTSRNIKVAPLNPALTFLNSIHYHTADEANDASKVCMDHDHEKLRPQLISTWMPNGVGAMPGKRVIFAETQIVQESIQIPGSDLHLTYQSSQASGYLSIVRMRLTGETIPPTLTHVHVGVEIEGALHVKTYEADPSLVHTFAWNKRNVYRQKVYGVTVARISVGYQHSTCQSPVWIAQTAKLQGYDVDISDIGGWGLDIHHHYNFHEGILQKGDGSTLHMKEYPRTVKVVMGTGLQRPLTCPDYCNGVAKDAKLLTPIALATGPDGSLYVGDFNLVRRITPDGKVYTILQLSATQVSYQYYLAVSPADGHLYISDPERHQILRLVRLEKVKDPSINSDPVVGSGQRCIPGDEGNCGDGGPALLARLSHPKGLAIAADRTMYIADGTNIRAVDPKGVIHTLIGHHGHHNHWSPAPCSGTLMANQAQLQWPTGLALSPLDGSLHFIDDRLVLRLTSDMKIRVVAGTPLHCSNGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRVNSIRVVDTAGNMRYFAGKQEGTGSQTCDCAIGGGSNGSATNSGVGGAGGSAYSTTVNPTRPNGGTTPTTPSGGNGNGNGNGSSATSSGGSVGGSNGSGGGANGGACICAGGIALSTGTGSSSGSNGGGTLASIVGSGGLMSTGPTTTTTVLLGAKTTAAGIGAATLNDDGTLSNAETLLSSNARFQAISAIAVAQDGVINVADQGSLHVLALEHYLPSHDENGEFHIPFPPSSEIYVFNRYGQHVATKDLTSGKTRYSFLYSKNTSFGRLSTVTDASGNKIQFLRDYSNVVSSIENTQDHKSEIQINGIGIMTKLSEKGRQEIELDYDSNTGLLNSRSSGGETYIYQYDEFGRVTGMILPSGEIVRITSQLADSQGLTVYVHASVESLFSRERIAGEANELLVLGGVRSTFLKRGQAHADAELKANNTLVIHGDNGVVVEASAVARHPLLEAALPVEAEMLAMWSHQSVTMGEGLTNSMYSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFNRVEGWAWGPAELKYSYDRHGLLSEITSQQDGIVSFVYNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVLPSGTRHSFSMQTSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTERELEYRWDFEYAAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQPAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLVGVEAQEPWGFRYDDNGNLLSLTYRGNTIPMEYNAQDRIVKFGEGQYKYDARGLVAQNAREERFHYNTQGLLVRASKRGRFDVRYYYDHLKRLTTRKDNFGNVTQFFYTNQQRPYEVSQIYSPRDGKLMSLTYDDVGHLIYAQVYRHKYYVATDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGDGRVYDPLIGQWMSPDWQRVAERIITPTRLHLYRFNGNDPINVGHERHYPEDFAAWMRTLGYNVGNLVPQLARDLWQPPALWGRPPANPVALNLRRPFDNIPTMAVESGFLAHLNVRRMSDFEQLSAPPRSALKCDVMDPSPKTIGSDTEPPFGKGIVVSRTADGQAIVSSVPAANAIYRDVYTSVFNRSKLLPFTFVVHNAQQDSFFFVKEDAWRATEDRQQLKRLQGQVNTTFHEITREATVGSGPAGAANGGAGSSSSSSSSSGGGSSSNTGNYLDVKIHGAHAIINLRYGTTVAKEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVKKKGATGGAAGVPNSRRRRRRSTDLIQEEEEELHREADC