wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized cyclin-L1-like protein C1296.05c (O94612)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Serine/threonine-protein kinase ppk23
- Serine/threonine-protein kinase srb10
Sequence:
MADSLVHSLASSSQLEAFDSFEYAEELCTLGSEWIQEAGVLLNLTQNCVIVCLILFRRYCTLYPPRVPDLDAIVMACVSIGSKTTETPASVQDICNVVVYLKERFKDTNFEARGFIAHDLYSEEMYSSRNRLSNMELEVLRALNFDTHIVIPHKLAIHYLQTLQLIDNKKLLQITWNFLNDASRTRLCVLYPPFSLACGCIAMAARVIGMKLPKDWYRVFDTTKEEIDSLTSILENFYKTSAIAHKTLYLIFTEQVSA
Protein: tRNA-specific adenosine deaminase TAD3 (AtTAD3) (EC 3.5.4.33) (Protein EMBRYO DEFECTIVE 2820) (tRNA-specific adenosine-34 deaminase TAD3) (F4KH86)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in RNA editing. Catalyzes the specific deamination of adenosine-34 in several cytosolic tRNA species. Generates inosine at the wobble position of the anticodon loop.
Subcellular location: Nucleus {ECO:0000269|PubMed:25315605}. Cytoplasm {ECO:0000269|PubMed:25315605}. Note=Localizes predominantly to the nucleus. {ECO:0000269|PubMed:25315605}.
Interaction partners:
- tRNA-specific adenosine deaminase TAD2
- tRNA
- Riboflavin biosynthesis protein PYRR
- Guanosine deaminase
- Lysine-rich arabinogalactan protein 19
- tRNA
- Riboflavin biosynthesis protein PYRD
- tRNA
- Histidinol-phosphate aminotransferase 2, chloroplastic
- tRNA-specific adenosine deaminase TAD1
Sequence:
MDSDAWEIIHIPEKPSLSPDHQPTVKVYASLIKPRFANTIVRHLCKIAPLEDLRHVKRVKKKILPDCGETQLTVILCLAPEHNDQLSDMPPDVQRLVDPYELSPFITQVCKYAAVSKEEWEEQSKIWPTSFHPPTYNIDGIGGFSEEETQSICKFMRVVIDMAVSGHTPLVNAAVIVDPSVRRIIASETDQVYASSAPRDMTSAETRPFEETGEICLNDTLEKQNGSLSALSCLNPWQWSLQPHDTENCSQWHPLRHASMVAIESSSARDRNLFPNPSKIFDQDHVPPSNTDSPAKKQKTSSQSPDVQNDSREETVRDPSMERPYLCTGYDIFLLLEPCTMCAMALVHQRIKRIFYAFPNTTAGGLGSVHRLQGEKSLNHHYAVFRVLLPDDALRQMTTV
Protein: Kinesin-like protein KIF15-A (Kinesin-like protein 2-A) (Xklp2-A) (Q91785)
Organism: Xenopus laevis (African clawed frog)
Function: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. Required for centrosome separation and maintenance of spindle bipolarity during mitosis.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes during metaphase on spindle microtubules, with a strong enrichment at spindle poles. Localizes to the minus ends of spindle pole and aster microtubules in a dynein- and dynactin-dependent manner. Detected diffusively in the cytoplasm. Localized (PubMed:8548825) at the centrosome during the interphase and throughout mitosis. {ECO:0000269|PubMed:8548825}.
Interaction partners:
Sequence:
MPPGTKGDPSNVTQPLPCLPSAEEDAIKVFVRIRPPVEGTLTGVDGEQGLCLTALSSTTIRLHSKPEPKMFTFDHVANVDTNQESVFSSVAKNIVESCMNGYNGTIFAYGQTGSGKTFTMLGPSESDNFTHNLRGVIPRSFEYLFFLINREKEKAGEGKSFLCKCSFIEIYNEQIFDLLDSASAGLFLREHIKKGVFVVGAVEQVVTSAAEAYQVLSMGWRNRRVASTSMNRESSRSHAVFTVTIESMEKTNDLVNIRSSQLNLVDLAGSERQKDTQTEGVRLKEAGSINRSLSCLGQVITALVDVANGRQRHICYRDSKLTFLLRDSLGGNAKTFYIANVHPGSKCFGETLSTLQFAQRAKLIKNKAVVNEDTQGNVSQLQAEVKKLKEQLSQLLSGQMPGDISVARVPSVGDNNMDYMNNFIEAMMILEKSDREKKVLLQKVVQLEDLCNKKEKFIQSNKMIVKFREDHISRLEKAHKEGRISLSNNEQDDFIAELKEEIRTLKEQVEHHPRVAKYALENHSLREENKRLHSLQSVKRAQEVTAQMIAELEKAFLEVSVSEKDRQVAPMHSTPIQLDNNSLMSAARMRERMLQLESELATSKQEYEEFKELTKKKQVEQESELQSLIKSNQHLENILEAIKANKRHEVSQLNRMHAAETIKNMTTPTKSYNLRSRLVPRLSPDAMPNGLMDTPKSGDVMDDIINEPIPPEMSEQAYEAIAEELRIVQEQVTALQAKLDEEEGKNIRLQQQVNKLELCSTQIQELFNSERSNWNKEQQDLIAQIKSLEKQKQENKSQEDVLKSEVHDLRVVLQSADRELGAVKGEYSLYREKQEKELSQLSARHMDVQLQLDNVRLEHETLLEEKRSLQDAFDNLEEVMKFEIDQLKQEISDSKHENETLRAEFSNLLELLETEKERRQKLTSQLEEDKENKTKELLQVVDENMHLRKQCSELMTKCEQQVTELHGLEHSLTSSKEMIADLEKKNTADKEVVADLMNQIQVHRTTIIHKTESIDLLTRELEDIHSKYSIVLLAKEESKTVIEEQEKQIEELRECLERKQSADNIEKELLCDDLAHATEELEKLTEAFNKQEALLHTHEKELVEKEQQISELTNQVKLMTDLEISREQEKIRPASSNSSSPVVLPETPRTPEGNPYDSEIANLQKRNTNLEILVSELNEERTSKNEEIIRLKMQLCETENMRLEIQNLQGMCKELKSQLENCNNVMKDSNDQKPSDMQDLKREIEKEVSERMEKGKATEHILKLQAELEETRNILCTKDHSLNELSKEIERTRSLEAKAFTEKEEIRSILEGKYEETEKLSHELDMLRKQVLFLAEENGKILGHQNPNQKIQYLVKLKKENNKLLEEAEKLRIENLFLKESKKCEHCN
Protein: Metallo-beta-lactamase family protein (Q72AI0)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Nitrogen fixation protein NifU
Sequence:
MRKIVESVYWVGAVDWDRRLFDSLVPLPDGTTYNAYLVEGSEKTALIDAVDPDMVDTLLGHLDGVEKLDYVISQHAEQDHSGTIALVLDLYPEAKVVTNAKAKSMLMDLLLIPDDKFIVVGDGETLSLGDKTLTFILTPWVHWPETMSTYLAEDKILFSCDFFGSHIATSDLFVRDQGRVHEAAKRYFGEIMMPFRTIIAKNLEKLGPYDIRMIAPSHGQIYDSPGWIIDAYRDWVSGVAHNLVAFPFVSMHGSTRLMVDHLAAALSERDVRVELFNLAVTDIGKLAMSLVDAGTIVLGTPTVLAGPHPMAAYAAFLANALRPKAKYLSIVGSYGWGGKTVETLAGMIPNLKVEVLDPVLCKGLPTDDTYGALDRLADAIAAKHKESGFQR
Protein: HTH-type quorum-sensing regulator RhlR (Elastase modulator) (Regulatory protein RhlR) (P54292)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Quorum-sensing regulator that controls the expression of multiple virulence factors in response to extracellular signaling molecules called autoinducers. Involved, among others, in the transcriptional regulation of genes that are responsible for rhamnolipid surfactant biosynthesis. Acts by binding to a specific sequence in the rhlAB regulatory region, both in the presence and in the absence of its autoinducer. In the former case it activates transcription of the promoter, whereas in the latter it acts as a transcriptional repressor. Also regulates the expression of the rmlBDAC operon, encoding dTDP-L-rhamnose biosynthetic enzymes, by binding to the rml box in the promoter region. In addition, is involved in the regulation of the production of elastase (lasB) and pyocyanine.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12657054}.
Interaction partners:
- Acyl-homoserine-lactone synthase
- Acyl-homoserine-lactone synthase
- 2-aminobenzoylacetyl-CoA thioesterase
- 3-
- Elastase
- Protease LasA
- Response regulator GacA
- Multiple virulence factor regulator MvfR
- 2-heptyl-3-hydroxy-4
- Rhamnosyltransferase 2
Sequence:
MRNDGGFLLWWDGLRSEMQPIHDSQGVFAVLEKEVRRLGFDYYAYGVRHTIPFTRPKTEVHGTYPKAWLERYQMQNYGAVDPAILNGLRSSEMVVWSDSLFDQSRMLWNEARDWGLCVGATLPIRAPNNLLSVLSVARDQQNISSFEREEIRLRLRCMIELLTQKLTDLEHPMLMSNPVCLSHREREILQWTADGKSSGEIAIILSISESTVNFHHKNIQKKFDAPNKTLAAAYAAALGLI
Protein: LD34837p (Spt20, isoform A) (Spt20, isoform D) (Q9VU86)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein will decrease acetylation
- SAGA-associated factor 29kDa
- Transcription-associated protein 1
- Transcriptional adaptor 3, isoform C
- Transcription initiation factor TFIID subunit 12
- SAGA complex subunit Spt3
- Transcriptional adapter 1-2
- SAGA factor-like TAF6
- SAGA complex subunit Spt7
- Transcriptional adapter 2b
Sequence:
MQSLDSSCQEADFIINDTLKKLKGSSNADHVQGLAVHAHGSGVHQTQFVQYGTSGSSPQLQPQQSYHQLHPTLQQQQFASSSSKSYLETSLLQAIPQIPAQPPICIFDDDESPTEGTGGSLGSLLTEPTSATPSGLPTAIAPSPSSCSSSTTTMSNFNSITSPSPVVPDLLLSTPPGVNSSLSNSSTGAASVSSKKSEKRPPSANSTASGGGHHLHHHHLHQTHNHHVLASPTSSPSKRQKSNSSSKESSSSSRSSAIPAASVSTATSSSQSARAGAGAASSNSNSKPPSSVCQSGNSKFFNLHEKIRDLYLQLLSNDLNYFAETGLKQRTRSFTLERLVDREKLNTIVVNLYPGNKGYSLALHYDEHMVLNPQTNEWSPTDKDETSSDAAGLGTGTGSHRSRPKPLAQDESQSKTEAGHAKHDFGLVEVLRWPYENDLLLQCIDREMLPEFLMDLLVAETVSLSDGEGTRVYAKPSVFYAGCVIAQIRDFRQTFATSTNICDMKHILLRPTNATLFAEVQQMGSQLPAEDKLALESQLVLATAEPLCLEPDPSIGRQAINSQHQRQLYNSHELRRQMKKFTQTAINRKRKLDQFTHHHGLELCDYLARLRQRPRTGSSSGGANATPATAPTNNPLVGAMLSSFTSKVPRRPHEVIRPIRPPTLEYPANLKVPEHVISVEKYAKAYEPLNEFSEACKDGCQPNCRHNFQPQLVEEYILETEREASEGRRALYHIKLSIFQRPSDAEYLGELYVDRDYREGERNGESCRFALGTRVHANRYIQQFREIFTEEGRKAVKITHLIPGHMPIVTHTGLTNEQRILLQQQQQQQQRQAQMQQQQQQQQQQVVVVANQQQQSQQQQQTQQAGQQLSATVHHVALPRQQITQKTLNLAGSNVINVQQNFRQQSAQQQQPQTYTIEAPQQQAAAQIVPQQQQQQQQQQQQHIHLQQLATGSSNTSTTTHQVSLSNGSLVLVQQQQPQQQSQQLAQALQHSGITIQPATIQQQQQQVKGTSVVGANSALRAQLNSNVPILQTQLKVQQQQIMQKQQQQQTTATSNNNNNNNNNNNMNNNTAIHPNPAINAIVNSIMNSANQYQQQQQQQHQQQHQQQTGNTSSNNNAAGSGGSTNNNGSSTSATTLKNSSNASILNLLNSAPAAMTSTPVASGTFTTSTGQQQPQTLTLVQHQQQSTPNTADAATATYVQTTRGTPTLVSTQRKQQSSEVLQNLLNANRKIGGGGTTTTTFRTNSAGNLIAVNLNQAGQSHHQQTGDGSQTVRVSMSALASQLASPPAVMTNPTTSYTVISSGNSAAAAAAWIQSPTGPVQQRILSSLRRDSTTAPPNAIVVGMAAPSPGSDSNASNASGFAVPNNLASTSSGGGGGGGALSALLTNAATPSPSGSDHSQSSQTHQNQALLERLSNVTSNVSAVSMPHMSPQQPQPTQQFITKTIVHSPATSSIHSPMSSPHPQPSASPQQQQQQQQQQTTATLNLQGINLSQLQGAMANFAGLQNVQVQIPGFTQPISLQFSGNSLQQQQSGNTATGAGTAQGQQRSVLVSVPVSSQQQQLPHTITLQTQSAPHHQQQHQQTQQQHAPPTGTIVSLPSSGPGTQTVVITNNSGGGVTAGSSTSGSAGGGGGSGATTAMLTLPIAQIVGAGVQKLNPQTIRTSNVGGGIGIAQQTVQQQTIQSQSGGNSTAAIQLLGTIQPRARNVQVVGTKQLANRQLITTQRQIGGSTLKIATTPVNAANVVTSSANLTTTPIVMSAQKLQLKTVKAPVQQQQQPQQQQQQLQQQHRILNQQSTATVSSQTLPSPNQVQVAQQQQQQQQQLQHIQIAGRATTASGAISQRTLTALAAAKQQQQQQQAAVNRRRSTTDATK
Protein: Tryptophan decarboxylase 1 (EC 4.1.1.28) (5-hydroxytryptophan decarboxylase TDC1) (Q6ZJK7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in serotonin biosynthesis. Catalyzes the decarboxylation of L-tryptophan to produce tryptamine, which is converted to serotonin by tryptamine 5-hydroxylase. May play a major role in serotonin biosynthesis during senescence. Accumulation of serotonin attenuates leaf senescence. Catalyzes the decarboxylation of 5-hydroxy-L-tryptophan to produce serotonin.
Interaction partners:
- Serotonin N-acetyltransferase 1, chloroplastic
- Serotonin N-acetyltransferase 2, chloroplastic
- histidinol-phosphate transaminase
- Delta-1-pyrroline-5-carboxylate synthase 2
- Delta-1-pyrroline-5-carboxylate synthase 1
- Aspartate aminotransferase
- Aspartate aminotransferase
- nicotianamine aminotransferase
- Aspartate aminotransferase, cytoplasmic
- Tryptophan aminotransferase-related protein 2
Sequence:
MGSLDTNPTAFSAFPAGEGETFQPLNADDVRSYLHKAVDFISDYYKSVESMPVLPNVKPGYLQDELRASPPTYSAPFDVTMKELRSSVVPGMTHWASPNFFAFFPSTNSAAAIAGDLIASAMNTVGFTWQASPAATEMEVLALDWLAQMLNLPTSFMNRTGEGRGTGGGVILGTTSEAMLVTLVAARDAALRRSGSDGVAGLHRLAVYAADQTHSTFFKACRLAGFDPANIRSIPTGAETDYGLDPARLLEAMQADADAGLVPTYVCATVGTTSSNAVDPVGAVADVAARFAAWVHVDAAYAGSACICPEFRHHLDGVERVDSISMSPHKWLMTCLDCTCLYVRDTHRLTGSLETNPEYLKNHASDSGEVTDLKDMQVGVGRRFRGLKLWMVMRTYGVAKLQEHIRSDVAMAKVFEDLVRGDDRFEVVVPRNFALVCFRIRAGAGAAAATEEDADEANRELMERLNKTGKAYVAHTVVGGRFVLRFAVGSSLQEEHHVRSAWELIKKTTTEMMN
Protein: Probable serine/threonine-protein kinase KKQ8 (EC 2.7.11.1) (P36004)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein BMH1
- Probable serine/threonine-protein kinase IKS1
Sequence:
MVMQEEKKRQQPVTRRVRSFSESFKNLFRPPRSRDSSPINVTRIPYRSSSTSPKRSSEPPRRSTVSAQILDPKNSPIRQRSYTLKCCTPGLSHPFRQTGSGASNSPTRHRSISGEEQEIVNSLPEYKRSASHTFHGIRRPRSRSSSVSSCDSSNGTTSSSDSQWAMDSLLDDSDNDLTPYRGSNKDILKSKDRAPYNYIDDYNKKALRRATSYPNPLPSKQFYNERLYTRRSHPDEESLESLPRFAGADVQCIIEQNGFKVYEDGSHEHNIKLSGVIAKLEKGNSLPAHRQGSLSRPRLGITLSGLFKHHKNECDIENALSLLPNVEKSQTNHEKRTGQSPNDSNRSSPTQGREDYLKIVNPDASLGSDELKLINSLSSRIHKSLQNYLQEKNLKPAECIGEQAPTFQDNYGHPVGLVGAGAYGEVKLCARLRNEKDSPPFETYHDSKYIYYAVKELKPKPDSDLEKFCTKITSEFIIGHSLSHYHKNGKKPAPNILNVFDILEDSSSFIEVMEFCPAGDLYGMLVGKSKLKGRLHPLEADCFMKQLLHGVKFMHDHGIAHCDLKPENILFYPHGLLKICDFGTSSVFQTAWERRVHAQKGIIGSEPYVAPEEFVDGEYYDPRLIDCWSCGVVYITMILGHYLWKVASREKDMSYDEFYKEMQRKNQFRVFEELKHVNSELATNRKIALYRIFQWEPRKRISVGKLLDMQWMKSTNCCLIYDST
Protein: FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8) (Q96CS3)
Organism: Homo sapiens (Human)
Function: Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12372427}. Lipid droplet {ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:23297223}. Endoplasmic reticulum {ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:23297223, ECO:0000269|PubMed:34739333}.
Interaction partners:
- Nuclear protein localization protein 4 homolog
- Ubiquitin recognition factor in ER-associated degradation protein 1
- UBX domain-containing protein 1
- Transitional endoplasmic reticulum ATPase
- Ubiquitin-associated domain-containing protein 2
- UBX domain-containing protein 7
- Derlin-2
- Large proline-rich protein BAG6
- Lipid droplet-regulating VLDL assembly factor AUP1
- Melanoma-associated antigen D1
Sequence:
MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIEAAVQDRLNEQEGVPSVFNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGDDHQDSDEFCRNTLCAPEVISLINTRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCIPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE
Protein: D-galactonate dehydratase family member Ent638_1932 (EC 4.2.1.-) (D-mannonate dehydratase) (EC 4.2.1.8) (A4WA78)
Organism: Enterobacter sp. (strain 638)
Function: Has low D-mannonate dehydratase activity (in vitro), suggesting that this is not a physiological substrate and that it has no significant role in D-mannonate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro).
Interaction partners:
- Fructuronate reductase
- Mannonate dehydratase
- D-galactonate dehydratase family member Ent638_0932
- TIGRFAM: 2-deoxy-D-gluconate 3-dehydrogenase
- TIGRFAM: 2-deoxy-D-gluconate 3-dehydrogenase
- PFAM: D-galactarate dehydratase/Altronate hydrolase domain protein
- 2-keto-3-deoxygluconate kinase
- PFAM: Alcohol dehydrogenase, zinc-binding domain protein
- PFAM: PfkB domain protein
- PFAM: ribulose-phosphate 3-epimerase
Sequence:
MKIVGAEVFVTCPGRNFVTLKITTDDGLVGLGDATLNGRELSVASYLKDHLCPQLIGRDAHRIEDIWQFFYKGAYWRRGPVTMSAISAVDMALWDIKAKAAGMPLYQLLGGASREGVMVYCHTTGHTIDDVLEDYARHKEMGFKAIRVQCGVPGMKTTYGMSKGKGLAYEPATKGDWPEEQLWSTEKYLDFTPKLFDAVRSKFGYDEHLLHDMHHRLTPIEAARFGKSIEEFRLFWMEDPTPAENQECFRLIRQHTVTPIAVGEVFNSIWDCKQLIEEQLIDYIRTTMTHAGGITGMRRIADFASLYQVRTGSHGPSDLSPICHAAALHFDLWVPNFGVQEYMGYSEQMLEVFPHSWTFDNGYMHPGEKPGLGIEFDEKLAAKYPYDPAYLPVARLEDGTLWNW
Protein: Serpentine receptor class X-43 (Protein srx-43) (O45767)
Organism: Caenorhabditis elegans
Function: Receptor for the ascaroside pheromone icas#9 which suppresses exploratory forgaging behavior. In response to ascaroside icas#9, may furthermore play a role in the expression of genes in the TGF-beta signaling pathway, such as daf-7, and in insulin signaling pathway, such as daf-28, which may in turn contribute to exploratory behavior.
Subcellular location: Cell membrane {ECO:0000305|PubMed:27799655}; Multi-pass membrane protein {ECO:0000255}. Perikaryon {ECO:0000269|PubMed:27799655}. Cell projection, cilium {ECO:0000269|PubMed:27799655}.
Interaction partners:
- Serpentine receptor class gamma
- Serpentine receptor class gamma
- G-protein coupled receptor daf-37
- SRBC-64)
Sequence:
MVLRNLTAMAIYDQTFVYSSDDALAGMVVSMECLTGLFLLVAVIIGCFRIAALKSPFGILMINQNCAQLMACINSGSFSTLGVLLNIKPVLSISYLFGNFSIFLLPVILISFLLMSFNRFCACFFPLRYQNLFSSSMIRTFIVFNWLLSLVAGSYLVVVRECNFVFYHFGWLFAGSVSVKCGTLLSLYSISIQTVLSITIVGLDVVTLVALMAFRSKVYQSHSVEVRRRELSFSGQVIIQGAVFLCHGAWYDMGHAILPGNDDRWKFFFTTSFSSNLLHVFDPVVVFAFNKEFRRWLFRNFNVPTAQKRIVTVVSAHNT
Protein: Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL) (Q5EBH1)
Organism: Mus musculus (Mouse)
Function: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A (By similarity). {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase 4
- GTPase HRas
- GTPase KRas
- Ras-related protein Rap-1A
- Ras association domain-containing protein 1
- Integrin alpha-L
- Ras-related protein Rap-1b
- Ras-related protein M-Ras
- GTPase NRas
- E3 ubiquitin-protein ligase Mdm2
Sequence:
MASPAIGQRPYPLLLDPEPPRYLQSLGGTEPPPPARPRRCIPTALIPAAGASEDRGGRRSGRRDPEPTPRDCRHARPVRPGLQPRLRLRPGSHRPRDVRSIFEQPQDPRVLAERGEGHRFVELALRGGPGWCDLCGREVLRQALRCANCKFTCHSECRSLIQLDCRQKGGPALDRRSPESTLTPTLNQNVCKAVEETQHPPTIQEIKQKIDSYNSREKHCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNPAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADYPLYLRLLAGPDTDVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIHQLQKKYNKFRQKLEEALRESQGKPG
Protein: Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST 1-1) (GST class-mu 1) (Glutathione S-transferase GT8.7) (pmGT10) (P10649)
Organism: Mus musculus (Mouse)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers.
Subcellular location: Cytoplasm.
Interaction partners:
- Glutathione S-transferase theta-1
- Cytochrome P450 1A1
- Glutathione S-transferase omega-1
- Microsomal glutathione S-transferase 1
- Glutathione S-transferase theta-2
- Epoxide hydrolase 1
- Glutathione S-transferase A4
- Maleylacetoacetate isomerase
- Cytochrome P450 2E1
- Glutathione S-transferase kappa 1
Sequence:
MPMILGYWNVRGLTHPIRMLLEYTDSSYDEKRYTMGDAPDFDRSQWLNEKFKLGLDFPNLPYLIDGSHKITQSNAILRYLARKHHLDGETEEERIRADIVENQVMDTRMQLIMLCYNPDFEKQKPEFLKTIPEKMKLYSEFLGKRPWFAGDKVTYVDFLAYDILDQYRMFEPKCLDAFPNLRDFLARFEGLKKISAYMKSSRYIATPIFSKMAHWSNK
Protein: Small protein MgtS (A5A616)
Organism: Escherichia coli (strain K12)
Function: Modulates intracellular Mg(2+) levels to maintain cellular integrity upon Mg(2+) limitation. Acts by binding and stabilizing the Mg(2+) transporter MgtA, thereby leading to increased intracellular level of Mg(2+). May inhibit FtsH proteolysis of MgtA.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:21778229, ECO:0000305|PubMed:19121005}; Single-pass membrane protein {ECO:0000269|PubMed:21778229}.
Interaction partners:
- Magnesium-transporting ATPase, P-type 1
- PhoP/PhoQ regulator MgrB
- Multidrug efflux pump accessory protein AcrZ
Sequence:
MLGNMNVFMAVLGIILFSGFLAAYFSHKWDD
Protein: cDNA, FLJ94608, Homo sapiens reticulon 4 interacting protein 1 (RTN4IP1), mRNA (B2R9Y1)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MPAWVIDKYGKNEVLRFTQNMMMPIIHYPNEVIVKVHAASVNPIDVNMRSGYGATALNMKRDPLHVKIKGEEFPLTLGRDVSGVVMECGLDVKYFKPGDEVWAAVPPWKQGTLSEFVVVSGNEVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLNDKNCTGKRVLILGASGGVGTFAIQVMKAWDAHVTAVCSQDASELVRKLGADDVIDYKSGSVEEQLKSLKPFDFILDNVGGSTETWAPDFLKKWSGATYVTLVTPFLLNMDRLGIADGMLQTGVTVGSKALKHFWKGVHYRWAFFMASGPCLDDIAELVDAGKIRPVIEQTFPFSKVPEAFLKVERGHARGKTVINVV
Protein: Cyp17a1 protein (B3DH80)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAEALILPWLLCLSLFSAVTLAALYLKQKMNGFVPAGNRSPPSLPSLPIIGSLLSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVRADWEKSPLMQHC
Protein: Methyl farnesoate epoxidase (EC 1.14.14.127) (Cytochrome P450 CYP15A1) (Q6R7M4)
Organism: Diploptera punctata (Pacific beetle cockroach)
Function: Catalyzes the conversion of methyl farnesoate to juvenile hormone III acid (methyl (2E,6E)-(10R)-10,11-epoxy-3,7,11-trimethyl-2,6-dodecadienoate) in juvenile hormone biosynthesis.
Interaction partners:
Sequence:
MVIALIVIIIFLVCLDVIKPRGYPPGPVWLPVVGSYLWFRREKSRVGYYHLVWSSLSSRYGPVTGMRLGTDYIVVACGYDAIRDILLRDEFDGRPDGYFFRLRTFGKRMGVVFTDGPVWQEQRRFCMQHLRKLGLGSRSMEAHIEEEARDLVASLHRRSNGGLTAIPMHDVFDICVLNSLWAMLAGHRFDLDDQRLVDLLDIVHKCFRMIDPSGGLLNQMPPLRFIAPRHSGYTNLMTHLNRIWNFLRETIDDHRKSFNADNMRDLIDLFLREMETSKCQNNSSFEDLQLVSLCLDLFMAGSETTSNTLGFAVLYMLLYPQVQRRVQDELDRCVGTDRQPTLQDRRSLRYLEAVLMEIQRHATIAPSGIPHKALKNTVLMGHTIPKGTTVLVSMWSLHRDVQHWGDPEVFRPERFISGNGNIKQDDWFMPFGIGKRRCIGETLAKASLFLFFSTLLHNFSILPSSESPLPSLEGYDGVTLSPKPFSAKLIPRK
Protein: COP1-interacting protein 4 (Q9FHU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pentatricopeptide repeat-containing protein At3g20730
- PPR superfamily protein
- Pentatricopeptide repeat-containing protein At4g31070
- COP1-interactive protein 1
Sequence:
MANRETNSSPEIRCVFVETNLDTRLILHVHKDEIISDFKDRLLKEHKQVFPEIGEIQISALKVKRRRKFYHFSDSLHVCKAFDGISRNWFMYIDAIRVDKGKMYAIMAADQNLELVEKKEEIANGLVLVDDMNNKDLTSGEGLETEVVEEKTRKRRIISPGGNTSPKKSKVDLSPSAVAATTELCGKVKGEVVSQSCAVSPREKLDDVVTRADIESGEKSGLSMGEKQQTSVTERLLEEKNLTVNSELVDGHTGGVVKEVPDNQTIKEALEKVDDLTGTIEQDLEKGGKTADIVMIDQEKDLPPASKLVDGQITSQVDERGEGRRLAPSAVDNLQTAEVVTNVDNQLEASSSLTTGPATEKKRKRMKSSKDHIKQNGNEMADILVDKVGSGEATLIGADEIQAASNLQVAGMASTPHAFVQESKTLDHIGKVTDTEHKVPQERVEIDADQAKSVKSTKKKSSRKAKTPAKEDTLVDFGAQNVEPIKVVDGEGHVNDIRNVLDSLQQRTEVEENMEKSGKKSSKRSKKKDSLNIVEEAQVVDSLQQKKEAEENLEKSGKKSSKKTKKKDSLNIVEEAQVLSVEVNNVAQEEASPINNPKDTDASFTPAKKTTESNASPLKKISEVTDNTEDLNRSMQVLKENADMGDNFGSSQKDDIVGGTNKEDQVTGGAKSKKEKKSLDLHPGGSIDGSMKVKETKGRVQPSSSGTSQLQSRAKNDRNGSKVDLSDASMKGTVNNKKEAVKKSSNSVTVNNSKVNVNNKKEVVKKISNSVTANKITTNFFKDAEEDESKTTSSDSSNAPSDSSSDNDSDVTSSMYMKQGNNLVGGTNRLSGSLQDILRSSKSYKAAKLTASLSQSVAFDDESLGINVVPDSQAAI
Protein: Erythropoietin receptor (Q2VBQ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MTKMRSDRLKIVFMLCLAFVTSGGKYFESKVAQLIRDETEDIKCFVEGKKDFTCFWEKEDGTNYSQDNYTFTYTYMNENKMDCAVSSLFLLSSNRSVFFCKLPKALFFTSLDVQVLRDGQMLYNRSLNVENILLTDPPRNVTVWSSGKEGQLNVSWLPPAVKYIDDSLIYEVRYAVEDSHMGKVEETKASTMLVLRGLQPDTRYKVWVRVKPDGVSYKGYWSSWTSPVIAVTPPGSMDPLIVLLVVFIILILCLLSMTVILSHHKFLLKKLWPDIPTPEHKFPGLFTVYKGDFKEWMSQNSGSMWARSVQMYTEELPSPLEVLSEVSLSPLDERKLVRDEDQRSDSGLTEPPHWLMEQLRALQENPESLSRSTLLQSHDTYITLNHSSGGQREDDVFEETLPLQTLFTSAGTSSINASHSDLGSLRQSSASGRLSSQSSFEDPNHPWPPKGPGYAYMAVADSGVSLDYSPMSSSRIIEIGKRSFYANEYKNEIFGYKWPFSAQQVQSGY