wanglab/gogpt-training-data huggingface dataset:
Protein: Exodeoxyribonuclease 8 (EC 3.1.11.-) (Exodeoxyribonuclease VIII) (EXO VIII) (P15032)
Organism: Escherichia coli (strain K12)
Function: Is involved in the RecE pathway of recombination. Catalyzes the degradation of double-stranded DNA. Acts progressively in a 5' to 3' direction, releasing 5'-phosphomononucleotides. Has a strong preference for linear duplex substrate DNA and appears to be unable to initiate degradation from single-stranded breaks in DNA.
Interaction partners:
- Protein RecT
- DNA replication and repair protein RecF
- RecBCD enzyme subunit RecB
- Protein RecA
- Protein RacC
- RecBCD enzyme subunit RecC
- Exodeoxyribonuclease I
- Single-stranded-DNA-specific exonuclease RecJ
- Double-strand break reduction protein
- ATP-dependent DNA helicase RecQ
Sequence:
MSTKPLFLLRKAKKSSGEPDVVLWASNDFESTCATLDYLIVKSGKKLSSYFKAVATNFPVVNDLPAEGEIDFTWSERYQLSKDSMTWELKPGAAPDNAHYQGNTNVNGEDMTEIEENMLLPISGQELPIRWLAQHGSEKPVTHVSRDGLQALHIARAEELPAVTALAVSHKTSLLDPLEIRELHKLVRDTDKVFPNPGNSNLGLITAFFEAYLNADYTDRGLLTKEWMKGNRVSHITRTASGANAGGGNLTDRGEGFVHDLTSLARDVATGVLARSMDLDIYNLHPAHAKRIEEIIAENKPPFSVFRDKFITMPGGLDYSRAIVVASVKEAPIGIEVIPAHVTEYLNKVLTETDHANPDPEIVDIACGRSSAPMPQRVTEEGKQDDEEKPQPSGTTAVEQGEAETMEPDATEHHQDTQPLDAQSQVNSVDAKYQELRAELHEARKNIPSKNPVDDDKLLAASRGEFVDGISDPNDPKWVKGIQTRDCVYQNQPETEKTSPDMNQPEPVVQQEPEIACNACGQTGGDNCPDCGAVMGDATYQETFDEESQVEAKENDPEEMEGAEHPHNENAGSDPHRDCSDETGEVADPVIVEDIEPGIYYGISNENYHAGPGISKSQLDDIADTPALYLWRKNAPVDTTKTKTLDLGTAFHCRVLEPEEFSNRFIVAPEFNRRTNAGKEEEKAFLMECASTGKTVITAEEGRKIELMYQSVMALPLGQWLVESAGHAESSIYWEDPETGILCRCRPDKIIPEFHWIMDVKTTADIQRFKTAYYDYRYHVQDAFYSDGYEAQFGVQPTFVFLVASTTIECGRYPVEIFMMGEEAKLAGQQEYHRNLRTLSDCLNTDEWPAIKTLSLPRWAKEYAND
Protein: T cell receptor beta constant 2 (A0A5B9)
Organism: Homo sapiens (Human)
Function: Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular location: Cell membrane {ECO:0000303|PubMed:20452950}.
Interaction partners:
Sequence:
DLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG
Protein: Kunitz-type serine protease inhibitor SOTI (Trypsin inhibitor) (SOTI) (P86549)
Organism: Spinacia oleracea (Spinach)
Function: Inhibitor of bovine trypsin with a Ki of 2.3 uM. Inhibits 50% of the proteolytic activity of P.rapae larvae midgut extract at a concentration of 20 ug/ml. Inhibitory activity against trypsin is reduced by 43% in the presence of the lysine modifier TBNS, but is not affected by dithiothreitol.
Interaction partners:
Sequence:
TVAACNSPKVGLDSDAELVR
Protein: StAR-related lipid transfer protein 3 (Protein ES 64) (Protein MLN 64) (START domain-containing protein 3) (StARD3) (Q61542)
Organism: Mus musculus (Mouse)
Function: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (By similarity). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Does not activate transcriptional cholesterol sensing (By similarity).
Subcellular location: Late endosome membrane {ECO:0000250|UniProtKB:Q14849}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA, VAPB or MOSPD2. {ECO:0000250|UniProtKB:Q14849}.
Interaction partners:
- Vesicle-associated membrane protein-associated protein A
- Vesicle-associated membrane protein-associated protein B
- STARD3 N-terminal-like protein
- Non-selective voltage-gated ion channel VDAC2
- Non-selective voltage-gated ion channel VDAC1
- Motile sperm domain-containing protein 2
- Non-selective voltage-gated ion channel VDAC3
- Protrudin
- Steroidogenic acute regulatory protein, mitochondrial
- GPI-specific phospholipase A2-like PGAP3
Sequence:
MSKRPGDLACDLERSLPALASLGTSLSHSQSLSSHFIPPPLEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLEQEVIHYSFQSSFFDIFVLAFFRFSGLLLGYAVLRLQHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQAAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVTGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFERSNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLVSYDVSSGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATTHCSKPPTHKYVRGENGPGGFIVLKSANNPRVCTFVWILNTDLKGRLPRYLIHQSLGATMFEFAFHLRQRVGELGARA
Protein: Regulatory factor X-associated protein (RFX-associated protein) (RFX DNA-binding complex 36 kDa subunit) (O00287)
Organism: Homo sapiens (Human)
Function: Part of the RFX complex that binds to the X-box of MHC II promoters.
Subcellular location: Nucleus.
Interaction partners:
- DNA-binding protein RFXANK
- DNA-binding protein RFX5
- MHC class II transactivator
- MHC class II regulatory factor RFX1
- Cyclic AMP-responsive element-binding protein 1
- Nuclear transcription factor Y subunit gamma
- Protein NLRC5
- Ankyrin-3
- Ankyrin-2
- Ankyrin-1
Sequence:
MEAQGVAEGAGPGAASGVPHPAALAPAAAPTLAPASVAAAASQFTLLVMQPCAGQDEAAAPGGSVGAGKPVRYLCEGAGDGEEEAGEDEADLLDTSDPPGGGESAASLEDLEDEETHSGGEGSSGGARRRGSGGGSMSKTCTYEGCSETTSQVAKQRKPWMCKKHRNKMYKDKYKKKKSDQALNCGGTASTGSAGNVKLEESADNILSIVKQRTGSFGDRPARPTLLEQVLNQKRLSLLRSPEVVQFLQKQQQLLNQQVLEQRQQQFPGTSM
Protein: Acyl-CoA hydrolase 2 (AtACH2) (EC 3.1.2.20) (Acyl-CoA thioesterase II) (ACT-II) (Hexadecanoyl-CoA hydrolase ACH2) (EC 3.1.2.2) (F4HU51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Active with both medium chain and long chain acyl-CoAs (e.g. 12:0-CoA, 14:0-CoA, 16:0-CoA, 18:0-CoA, 16:1-CoA, 18:1-CoA, 18:2-CoA and 20:4-CoA) as substrates, palmitoleoyl-CoA (16:1-CoA) being the favorite substrate.
Subcellular location: Peroxisome matrix {ECO:0000250|UniProtKB:O14734}. Note=Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded. {ECO:0000250|UniProtKB:O14734}.
Interaction partners:
- Very-long-chain enoyl-CoA reductase
- Cytochrome P450 86A7
- Cytochrome P450 86A4
- Cytochrome P450 704B1
- Cytochrome P450 86A1
- Acyl-CoA thioesterase family protein.
- Cytochrome P450 86A2
- Peroxygenase 1
- Cytochrome P450 86B1
- Cytochrome P450 86A8
Sequence:
MNTESVVEFLGNVPLLQKLPSSSLKKIAQVVVPKRYGKGDYVVREDQTWDGCYFILQGEAQVSGPDEEDNRSEFLLKQYDYFGVGLSGNVHSADIVAMSQLTCLVLPRDHCHLLETNSIWQSDTSLDKCSLVERILQLDPLELNIFRGITLPDAPIFGKVFGGQFVGQALAAASKTVDFLKVVHSLHSYFLLVGDIDIPIIYQVHRIRDGNNFATRRVDAVQKGNIIFILLASFQKEQQGFEHQESTMPSVPDPDTLLSLEELRESRITDPHLPRSYRNKVATRNFVPWPIEIRFCEPSNSTNQTKSPPRLNYWFRAKGRLSDDQALHRCVVAFASDLIFCGVGLNPHRRKGVKSAALSLDHAMWFHRPLRADEWLLYVIVSPTAHETRGFVTGQMFNRKGELVVSLTQEALLREARPPKPSGTSKL
Protein: Immunity-related GTPase family M protein 2 (EC 3.6.5.-) (Interferon-inducible GTPase 2) (A0A140LIF8)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:34078740}. Golgi apparatus membrane {ECO:0000269|PubMed:34078740}. Cytoplasm, cytosol {ECO:0000269|PubMed:34078740}. Note=Localizes to parasitophorous vacuole membranes. {ECO:0000269|PubMed:34078740}.
Interaction partners:
- Immunity-related GTPase family M protein 3
- Immunity-related GTPase family M protein 1
- Signal transducer and activator of transcription 1
- Guanylate-binding protein 3
- Guanylate-binding protein 2
- Interferon-inducible GTPase 1
- GTP-binding protein
- Protein mono-ADP-ribosyltransferase PARP14
- Guanylate-binding protein 7
- Guanylate-binding protein 6
Sequence:
MEEAVESPEVKEFEYFSDAVFIPKDGNTLSVGVIKRIETAVKEGEVVKVVSIVKEIIQNVSRNKIKIAVTGDSGNGMSSFINALRLIGHEEKDSAPTGVVRTTQKPTCYFSSHFPYVELWDLPGLGATAQSVESYLEEMQISIYDLIIIVASEQFSLNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRDSLQKEKVKEHPMFLVSVFKPESHDFPKLRETLQKDLPVIKYHGLVETLYQVCEKTVNERVESIKKSIDEDNLHTEFGISDPGNAIEIRKAFQKTFGLDDISLHLVALEMKNKHFNTSMESQETQRYQQDDWVLARLYRTGTRVGSIGFDYMKCCFTSHHSRCKQQKDILDETAAKAKEVLLKILRLSIPHP
Protein: Naringenin 8-dimethylallyltransferase 1, chloroplastic (SfN8DT-1) (EC 2.5.1.70) (B1B3P3)
Organism: Sophora flavescens (Ku shen)
Function: Involved in the biosynthesis of sophoraflavanone G (SFG). Can use flavanones (naringenin, liquiritigenin and hesperetin) as substrates, but not flavonols or isoflavones. Shows a strict specificity for dimethylallyl diphosphate.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:18218974}; Multi-pass membrane protein {ECO:0000269|PubMed:18218974}.
Interaction partners:
Sequence:
MGSMLLASFPGASSITTGGSCLRSKQYAKNYDASSYVTTSWYKKRKIQKEHCAAIFSKHNLKQHYKVNEGGSTSNTSKECEKKYVVNAISEQSFEYEPQTRDPESIWDSVNDALDIFYKFCRPYAMFTIVLGATFKSLVAVEKLSDLSLAFFIGWLQVVVAVICIHIFGVGLNQLCDIEIDKINKPDLPLASGKLSFRNVVIITASSLILGLGFAWIVDSWPLFWTVFISCMVASAYNVDLPLLRWKKYPVLTAINFIADVAVTRSLGFFLHMQTCVFKRPTTFPRPLIFCTAIVSIYAIVIALFKDIPDMEGDEKFGIQSLSLRLGPKRVFWICVSLLEMTYGVTILVGATSPILWSKIITVLGHAVLASVLWYHAKSVDLTSNVVLHSFYMFIWKLHTAEYFLIPLFR
Protein: Tyrosine protein-kinase src-1 (EC 2.7.10.2) (SRC oncogene related protein 1) (G5EE56)
Organism: Caenorhabditis elegans
Function: Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine. May be dispensable for pharyngeal muscle organization in the adult. Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion. Plays a role in the migration of the QR neuroblast, a precursor of the AVM neuron, and in the migration of the axon cone of AVM, ALM, CAN and PVM neurons. May act downstream of migratory protein mig-13 to control AVM neuron migration. Probably downstream of integrin ina-1/pat-3, plays a role in the clearance of apoptotic cells during mid-embryogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20226672}; Lipid-anchor {ECO:0000255}; Cytoplasmic side {ECO:0000269|PubMed:20226672}. Cell projection, phagocytic cup {ECO:0000269|PubMed:20226672}. Note=Co-localizes with ina-1 at the site of the phagosomal cup formation during apoptotic cell engulfment. {ECO:0000269|PubMed:20226672}.
Interaction partners:
- Inactive tyrosine-protein kinase kin-32
- Receptor tyrosine-protein kinase let-23
- Raf homolog serine/threonine-protein kinase
- Caveolin-1
- Caveolin-2
- Runt-related transcription factor rnt-1
- Protein roller-3
- FUN14 domain-containing protein fndc-1
- Ras-related protein ced-10
- Mitogen-activated protein kinase pmk-1
Sequence:
MGCLFSKERRSGGSDMGVSERIDVSRFQTPQQQTVFHVNNGGNEGTISQLNGTSDGMMGNGRGGGGGGGAQERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNYAPPSA
Protein: WRKY transcription factor-like protein (Q1PEF0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein DMP10
- Vesicle transport protein
- Vesicle transport protein
- Vesicle transport protein
- Vesicle transport protein
- Tobamovirus multiplication protein 2A
Sequence:
MEEILMSMIFNGINLVKELEFSLSSQESPESDLSSSLSSISTLFGDVNERLKTLLAWRNSLSQYQPEPEPVLMLDMTN
Protein: Atrophin 1 (Q86V38)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL
Protein: LIM domain-containing protein jub (Q9VY77)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway.
Subcellular location: Cell junction, adherens junction {ECO:0000269|PubMed:20303269}.
Interaction partners:
- Serine/threonine-protein kinase Warts
- Scaffold protein salvador
- Augmin complex subunit dgt3
- RNA-binding protein 42
- Catenin alpha
- Transcriptional coactivator yorkie
Sequence:
MTTQRTQTQARNPGNSDSDYETLMQRLHIGGGGGAGVGGGGGSGGPGDGGVAMRSYQRSPGAIENYLQESQQQQQQHQMQQMQQLHHNQDYKLYERGNIIAASKYATPRPVEQIQHTHNGSAQIYAPTAQILGQRIAPQKHSPVYENLEFYGQFDSNHKRAQPQSPGSRQSAILNGYLLMQPIRAGRFAHTPVPENQGSASLGTTRAAGGPPPPSGRSAALGPTGDLEEHAAPIYENIIPHSGQRAQPQASPATATMYQEMQPTSNSSGSSSTAGLDLNALLASPMHQRSISSNTASSSSLGSPTQRYRNLSLPSHLSPVPTAQSVAKLQQHTPVKSPGGAINVSVNPNYIEDINSSDYVCMTANLHRNTAAGLATGRAAATGAPAQRTVQEPPIITSSLAMGMATAAPPTTSNAPTSAAAAPAAPTSTASLRATPIAMTAPLAVATSPTPSQGSTAVNAALKPRRGLTKNLLPYSVTPPRPAGPTEAQRKIEELTRQLEEEIEQSEEHGEYFGICHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGRVYCEEDYMYSGFQQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDHKIYCVNDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDKDFHVDCYICEECGMQLTDEPDKRCYPLDGRLLCRGCHLQRLALQSSPHARHQEPVCASYQYMG
Protein: Protein trichome birefringence-like 31 (Q1PFD9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Protein REDUCED WALL ACETYLATION 2
- Protein REDUCED WALL ACETYLATION 3
- Glucuronoxylan 4-O-methyltransferase 1
- Protein REDUCED WALL ACETYLATION 4
Sequence:
MSIQTTADSRMIQSIFQVVLVSLLVLGSVRWILDELKSKESRISKLYGFRQKEAVFVTKEDQLDESCNVFEGQWVWDNVSYPLYTEKSCPYLVKQTTCQRNGRPDSYYQNWRWKPSSCDLPRFNALKLLDVLRNKRLMFIGDSVQRSTFESMVCMVQSVIPEKKKSFHRIPPMKIFKAEEYNASIEYYWAPFIVESISDHATNHTVHKRLVKLDAIEKHSKSWEGVDVLVFESYVWWMHQPKINATYGDTSEVREYNVTTAYKMALETWAKWFKTKINSEKQKVFFTSMSPTHLWSWEWNPGSDGTCYDELYPIDKRSYWGTGSNQEIMKIVGDVLSRVGENVTFLNITQLSEYRKDGHTTVYGERRGKLLTKEQRADPKNYGDCIHWCLPGVPDTWNEILYAYLLRSHRNFF
Protein: Probable transcriptional regulatory protein TcrX (O69730)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Member of the two-component regulatory system TcrY/TcrX.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Probable sensor histidine kinase TcrY
- Sensor-type histidine kinase PrrB
- Sensor histidine kinase TrcS
- Sensor histidine kinase component HK1
- Sensor-like histidine kinase SenX3
- histidine kinase
- Signal transduction histidine-protein kinase/phosphatase MprB
- Sensor histidine kinase MtrB
- Sensor histidine kinase component HK2
Sequence:
MRRADGQPVTVLVVDDEPVLAEMVSMALRYEGWNITTAGDGSSAIAAARRQRPDVVVLDVMLPDMSGLDVLHKLRSENPGLPVLLLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDSGAQLVVGDLVLDEDSHEVMRAGEPVSLTSTEFELLRFMMHNSKRVLSKAQILDRVWSYDFGGRSNIVELYISYLRKKIDNGREPMIHTLRGAGYVLKPAR
Protein: Carbonic anhydrase (EC 4.2.1.1) (E9QB97)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Semaphorin-4G.
- Actin filament-associated protein 1-like 1
Sequence:
MEQLTLVLLFVTSLNFASAGVDGDYWTYSGELDQKHWAEKYHDCGGQQQSPIDIQRRKVRYSPRMQQLELTGYEDIRGSFLMKNNGHSVEIQLPSTMKITKGFPHQYTAVQMHLHWGGWDLEASGSEHTMDGIRYMAELHVVHYNSEKYPSFEEAKNKPDGLAVLAFFFEDGHFENTYYSDFISNLANIKYVGQSMSISNLNVLSMLSENLSHFYRYKGSLTTPPCFESVMWTVFDTPITLSHNQIRKLESTLMDHDNKTLWNDYRMAQPLNERVVESTFLPRLSKGGMCRQEEIEAKLKRIESLILSLDKKAVQGKQPISPLVLYFPQKNVESFAVVNLTHPMELKSFTACMNVQIPPIRDLTVLSYSTSHDNELMISLGSEVGLWIGDEFVNLSFDLPSSDWTNYCLTWASHNGGAELWVNGVVGKERYIRTGYIIPAGGRLILGKDQDGFLGISVNDAFVGHMSDVNIWDYVLTEGEIVEQMSCDNGKVKGNVLSWGVTQLSLYGGVQLQGEQVCHRDNNNNRETEK
Protein: Bone morphogenetic protein 4 (A5HMF8)
Organism: Anas platyrhynchos (Mallard) (Anas boschas)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MIPGNRMLMVILLCQVLLGGTNHASLIPETGRKKVAELQGQQAGSGRRSAQSHELLRGFETTLLQMFGLRRRPQPSKSAVIPTYMLDLYRLQSGEEEESLQEISLQYPERSTSRANTVRSFHHEEHLETVPGPSEAPWIRFVFNLSSAPENEVISSAELRLYREQVEEPSAAWERGFHRINIYEVMKPLSERAQAITRLLDTRPVHHNVTRWETFDVSPAVIRWTKDKQPNHGLVIEVTHLHHAQTHQGKHVRISRSLPQGRGDWAQLRPLLVTFGHDGRGHALTRRARRSPKHQRSRKNKKNCRRHALYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Protein: Epididymis secretory protein Li 42 (Ras homolog gene family, member Q, isoform CRA_d) (V9HWD0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT
Protein: S-acyltransferase (EC 2.3.1.225) (Palmitoyltransferase) (A4GXC0)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
LGDRCVEQFDHHCPWVSNCIGKRNKWDFFLFLVLEVSAMLSTGAVAITRIVTDPLAPSSFFPWINNAFTHHIGAITFLIVDFFLFFGVAALTVVQASQIARNITTNEMANVMRYSYLRSAIGRFRNP
Protein: ELAV-like protein 1 (Elav-like generic protein) (Hu-antigen R) (HuR) (MelG) (P70372)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation. Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9763509}. Nucleus {ECO:0000269|PubMed:9763509}. Cytoplasm, Stress granule {ECO:0000269|PubMed:27616329}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q15717}. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2. Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (By similarity). Localizes to the stress granules in the presence of PLEKHN1. {ECO:0000250|UniProtKB:Q15717, ECO:0000269|PubMed:27616329}.
Interaction partners:
- Protein argonaute-2
- Ubiquitin-fold modifier-conjugating enzyme 1
- Cytotoxic granule associated RNA binding protein TIA1
- Bcl-2-like protein 2
- Polyadenylate-binding protein 2
- Cyclin-A2
- Nucleolysin TIAR
- Cyclin-A1
- Ras GTPase-activating protein-binding protein 1
- G1/S-specific cyclin-D1
Sequence:
MSNGYEDHMAEDCRDDIGRTNLIVNYLPQNMTQEELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAISTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNMALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGISGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK
Protein: Tail fiber protein (Gene product 17) (Gp17) (Tail fiber protein gp17) (P03748)
Organism: Escherichia phage T7 (Bacteriophage T7)
Function: Structural component of the short non-contractile tail. The tail comprises six fibers made of gp17 trimers, 2 nm in diameter and 32 nm in length. May attach to host lipopolysaccharides (LPS) to mediate primary attachment to the host cell.
Subcellular location: Virion.
Interaction partners:
Sequence:
MANVIKTVLTYQLDGSNRDFNIPFEYLARKFVVVTLIGVDRKVLTINTDYRFATRTTISLTKAWGPADGYTTIELRRVTSTTDRLVDFTDGSILRAYDLNVAQIQTMHVAEEARDLTTDTIGVNNDGHLDARGRRIVNLANAVDDRDAVPFGQLKTMNQNSWQARNEALQFRNEAETFRNQAEGFKNESSTNATNTKQWRDETKGFRDEAKRFKNTAGQYATSAGNSASAAHQSEVNAENSATASANSAHLAEQQADRAEREADKLENYNGLAGAIDKVDGTNVYWKGNIHANGRLYMTTNGFDCGQYQQFFGGVTNRYSVMEWGDENGWLMYVQRREWTTAIGGNIQLVVNGQIITQGGAMTGQLKLQNGHVLQLESASDKAHYILSKDGNRNNWYIGRGSDNNNDCTFHSYVHGTTLTLKQDYAVVNKHFHVGQAVVATDGNIQGTKWGGKWLDAYLRDSFVAKSKAWTQVWSGSAGGGVSVTVSQDLRFRNIWIKCANNSWNFFRTGPDGIYFIASDGGWLRFQIHSNGLGFKNIADSRSVPNAIMVENE