Protein: Protein pop-1 (Posterior pharynx defect protein 1) (TCF transcription factor pop-1) (Q10666)
Organism: Caenorhabditis elegans
Function: Transcription factor. Part of the Wnt signaling asymmetry pathway. Activates or represses target gene expression, depending on upstream Wnt signals and interactions with transcription co-regulators, such as beta-catenin/sys-1 or zinc finger transcription factor ref-2. Essential for the specification of the mesodermal and endodermal cell fates in early embryos. Required in many asymmetrical cell divisions in the early embryo and during larval development. Reciprocal distribution patterns of sys-1 and pop-1 in the daughters of anterior-posterior cell divisions functions in specifying cell fate; a higher sys-1 to pop-1 ratio promotes the posterior cell fate, whereas a low sys-1 to pop-1 ratio promotes the anterior fate. Involved in modulating nuclear localization or nuclear retention of sys-1. Involved in the terminal asymmetrical division of many embryonic neuroblasts; for example in the SMDD/AIY neuron lineage. In complex with ref-2, positively modulates expression of LIM/homeobox protein ttx-3 in anterior daughter cells of the SMDD/AIY lineage. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Similarly, involved in asymmetrical division of seam cells, a stem cell-like lineage. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:10380924, ECO:0000269|PubMed:15649465, ECO:0000269|PubMed:17567664, ECO:0000269|PubMed:19386265, ECO:0000269|PubMed:19427847, ECO:0000269|PubMed:25569233, ECO:0000269|PubMed:26073017, ECO:0000269|PubMed:31740621}. Cytoplasm {ECO:0000269|PubMed:10380924}. Note=Predominantly nuclear, but is exported out of the nucleus and into the cytoplasm upon lit-1-mediated phosphorylation (PubMed:10380924, PubMed:15066285). Soon after the nuclei reform in telophase, pop-1 levels decrease in the posterior nucleus, in contrast to the anterior nucleus (PubMed:31740621). There is a ~2-fold nuclear enrichment of pop-1 in the anterior compared with posterior daughter cells at the time of cytokinesis (PubMed:19386265, PubMed:26073017, PubMed:31740621). {ECO:0000269|PubMed:10380924, ECO:0000269|PubMed:15066285, ECO:0000269|PubMed:31740621}.
Interaction partners:
- Beta-catenin/armadillo-related protein 1
- Armadillo repeat-containing protein wrm-1
- Serine/threonine kinase NLK
- Beta-catenin homolog sys-1
- Beta-catenin-like protein hmp-2
- Transcription factor unc-37
- Adenomatous polyposis coli protein-related protein 1
- Dwarfin sma-4
- Dwarfin sma.
- Protein cbp-1
Sequence:
MMADEELGDEVKVFRRDEDADDDPMISGETSEQQLADDKKEAVMEAELDGAGRNPSIDVLKSAFPKVEPMSPSFPGLMSHFSPGYSAAALPMFMPLFMNPYAAALRSPSLMFPMGAMSPTFPMFPPSPVYGAAIAAAAAKQHFENMAPLNMRAGHPMNQMGMPPYMHPSSMAPQNVDRRAQGGGKAKKDDHVKKPLNAFMWFMKENRKALLEEIGNNEKQSAELNKELGKRWHDLSKEEQAKYFEMAKKDKETHKERYPEWSARENYAVNKKKTKKRRDKSIPSENNDQKKCRARFGVNNTEMWCKFCKRKKKCEYATDRSGGSDITDSQDGRGTSGAYSSSSESPSPKANAGIALTTQQQQAAMMHTMLMQMRLGSTTGASTHVPSPLASSSAGRSPLDANASDSESDVEEEEDEQIDPTVMQQTHDMLMQESMCTI