wanglab/gogpt-training-data huggingface dataset:
Protein: trypsin (EC 3.4.21.4) (Q9VQA3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
- GH21475p
- RT03039p
- Seminal fluid protein 24F
- Ductus ejaculatorius peptide 99B
- SCP domain-containing protein
- Odorant binding protein c
- RE43153p
- GEO10302p1
- Accessory gland protein Acp53Ea
- glutaminyl-peptide cyclotransferase
Sequence:
MLLKGILLLVSIAQIAADFKSIGIEQAPWQASVQINDKHHCGGVIYSEDIILTIAECVRKARLEFISVRVGSAQENAGGTVLKVEKMRLQVLGLRPSDVAILQLRSPLYLDGGIRAIPLATIPLVPGTNASVSGWGQLSAMNPSSEVLLRVDVKIQDQLMCATNLALKGRLMSVGEICAAPAGEIPYACQGFVGGPLVANNRLYGILSWQSACDVLNKSSVYANIAMFKVWIESTVKLMNFFRIG
Protein: Sphingosine-1-phosphate transporter MFSD2B (Major facilitator superfamily domain-containing protein 2B) (hMfsd2b) (A6NFX1)
Organism: Homo sapiens (Human)
Function: Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (By similarity). Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (Probable). Release of sphingosine-1-phosphate is facilitated by a proton gradient (By similarity). In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (Probable). In addition to export, also able to mediate S1P import (By similarity). Does not transport lysophosphatidylcholine (LPC) (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:29045386, ECO:0000269|PubMed:29563527}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the cell membrane and intracellular membranes. {ECO:0000269|PubMed:29045386}.
Interaction partners:
- Sphingosine-1-phosphate transporter SPNS2
- Protein spinster homolog 1
- Sphingosine kinase 1
Sequence:
MAAPPAPAAKGSPQPEPHAPEPGPGSAKRGREDSRAGRLSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTGSGRLMPWVLGCTPFIALAYFFLWFLPPFTSLRGLWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIVSGAHRPHRCEATATPGPVTVSPNAAHLYCIAAAVVVVTYPVCISLLCLGVKERPDPSAPASGPGLSFLAGLSLTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSAFGIFAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHRHGPGLETIFYSSYVFFTKLSGACALGISTLSLEFSGYKAGVCKQAEEVVVTLKVLIGAVPTCMILAGLCILMVGSTPKTPSRDASSRLSLRRRTSYSLA
Protein: Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) (Q8IYB3)
Organism: Homo sapiens (Human)
Function: Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
Subcellular location: Nucleus matrix {ECO:0000269|PubMed:12624182, ECO:0000269|PubMed:9531537}. Nucleus speckle {ECO:0000269|PubMed:11546874, ECO:0000269|PubMed:9531537}.
Interaction partners:
- Serine/arginine repetitive matrix protein 2
- RNA-binding protein with serine-rich domain 1
- Regulator of nonsense transcripts 3A
- RNA-binding protein 25
- Regulator of nonsense transcripts 2
- Nuclear RNA export factor 1
- Regulator of nonsense transcripts 1
- THO complex subunit 4
- Transcription elongation regulator 1
- Serine/arginine-rich splicing factor 11
Sequence:
MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRKAQVSPQS
Protein: Neuroendocrine protein 7B2 (Q59E04)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a molecular chaperone for neuroendocrine convertase amon/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive amon in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated (By similarity). Also required for cleavage of amon.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01165}.
Interaction partners:
- Neuroendocrine convertase 2
- Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2
Sequence:
MLFRSQTHVFPGVYMMVAMLVVALSGYQVQSYSAKDILADVLMTDLLNRMDKDMQVGYYDVGNEAAAGSKDNVDLVSRSEYARLCDGGSDCILQSGSASGAASHPSLRDDEFLQHSSLWGHQFISGGMGEGPNRYPTIVKNDAGLPAYCNPPNPCPEGYDMETQGGSCIVDFENTAIFSREFQAAQDCTCDNEHMFDCSEQDSADVGGDKGDLNSAVEQYIMQMGQENSLNNVNSLAKKAGYPVMPDPRLDDAVINPFLQGDRLPIAAKKGNLLFH
Protein: Myoblast determination protein 1 homolog A (Myogenic factor 1) (P13904)
Organism: Xenopus laevis (African clawed frog)
Function: May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
Subcellular location: Nucleus.
Interaction partners:
- LOC496378 protein
- Myocyte-specific enhancer factor 2D homolog isoform X1)
- histone acetyltransferase
- histone acetyltransferase
- Uncharacterized protein.
- Uncharacterized protein.
- T-box transcription factor T
- Uncharacterized protein.
- BHLH domain-containing protein.
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 S homeolog isoform X1
Sequence:
MELLPPPLRDMEVTEGSLCAFPTPDDFYDDPCFNTSDMSFFEDLDPRLVHVTLLKPEEPHHNEDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERRRLSKVNEAFETLKRYTSTNPNQRLPKVEILRNAIRYIESLQALLHDQDEAFYPVLEHYSGDSDASSPRSNCSDGMMDYNSPPCGSRRRNSYDSSFYSDSPNDSRLGKSSVISSLDCLSSIVERISTQSPSCPVPTAVDSGSEGSPCSPLQGETLSERVITIPSPSNTCTQLSQDPSSTIYHVL
Protein: Alpha-hemolysin translocation ATP-binding protein HlyB (Q1R2T6)
Organism: Escherichia coli (strain UTI89 / UPEC)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDSCHKIDYGLYALEILAQYHNVSVNPEEIKHRFDTDGTGLGLTSWLLAAKSLELKVKQVKKTIDRLNFISLPALVWREDGRHFILTKVSKEANRYLIFDLEQRNPRVLEQSEFEALYQGHIILIASRSSVAGKLAKFDFTWFIPAIIKYRRIFIETLVVSVFLQLFALITPLFFQVVMDKVLVHRGFSTLNVITVALSVVVVFEIILSGLRTYIFAHSTSRIDVELGAKLFRHLLALPISYFESRRVGDTVARVRELDQIRNFLTGQALTSVLDLLFSFIFFAVMWYYSPKLTLVILFSLPCYAAWSVFISPILRRRLDDKFSRNADNQSFLVESVTAINTIKAMAVSPQMTNIWDKQLAGYVAAGFKVTVLATIGQQGIQLIQKTVMIINLWLGAHLVISGDLSIGQLIAFNMLAGQIVAPVIRLAQIWQDFQQVGISVTRLGDVLNSPTESYHGKLALPEINGDITFRNIRFRYKPDSPVILDNINLSIKQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIIDNISLANPGMSVEKVIYAAKLAGAHDFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMRNMHKICKGRTVIIIAHRLSTVKNADRIIVMEKGKIVEQGKHKELLSEPESLYSYLYQLQSD
Protein: Probable biotin-dependent acyl-coenzyme A carboxylase beta2 subunit (EC 2.1.3.-) (O86318)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit transfers the CO2 from carboxybiotin to the CoA ester substrate.
Interaction partners:
- Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase alpha1 subunit
- Acyl-CoA dehydrogenase FadE12
- Exopolyphosphatase
- Probable acyl-CoA dehydrogenase FadE13
- Probable enoyl-CoA hydratase EchA7
- Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase alpha1 subunit
- Biotin-dependent acyl-coenzyme A carboxylase alpha3 subunit
- Probable biotin-dependent acyl-coenzyme A carboxylase beta3 subunit
- Uncharacterized lipoprotein LprP
- Probable fatty acid synthase Fas
Sequence:
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGNLTPRERIELLVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMFRDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADYFALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEAESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM
Protein: Type I interferon (Q5U778)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MYTMQSWSCIFLIICSMQSVCHCCDWIRHHYGHLSAEYLSLLDQMGGDITNQNAPVLFPTSLYRHIDDAEFEDKVRFLKETIYQITKLFDGNMKSVTWDKKNLDDFLNILERQLENLNSCVSPAMKPERRLKHYFKKLNRKVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY
Protein: Serine/threonine-protein kinase akt-2 (EC 2.7.11.1) (Protein kinase B akt-2) (PKB akt-2) (Q9XTG7)
Organism: Caenorhabditis elegans
Function: Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-1 and sgk-1, promotes cell survival during embryonic development. Plays a role in maintaining the gonadal basement membrane through antagonizing akt-1 activity.
Interaction partners:
- Forkhead box protein O
- Phosphatidylinositol 3-kinase age-1
- Phosphoinositide 3-kinase adapter subunit
- 3-phosphoinositide-dependent protein kinase 1
- DAF-15
- Target of rapamycin homolog
- RICTOR_N domain-containing protein
- Glycogen synthase kinase-3
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
- Serine/threonine-protein kinase akt-1
Sequence:
MSTENAHLQKEDIVIESWLHKKGEHIRNWRPRYFILFRDGTLLGFRSKPKEDQPLPEPLNNFMIRDAATVCLDKPRPNMFIVRCLQWTTVIERTFYADSADFRQMWIEAIQAVSSHNRLKENAGNTSMQEEDTNGNPSGESDVNMDATSTRSDNDFESTVMNIDEPEEVPRKNTVTMDDFDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLYACVHPFLTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKTFSEARTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDIDYDRSVDWWGVGVVMYEMMCGRLPFSAKENGKLFELITTCDLKFPNRLSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFFKDVDWEATLRKEVEPPFKPNVMSETDTSFFDREFTSMPVQLTPPRRGEELPTVDEEEELQANFIQFASYYVSGSLERSYDTNRSADKYEIR
Protein: B3 domain-containing protein REM20 (Protein REPRODUCTIVE MERISTEM 20) (Q8LAV5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00326}.
Interaction partners:
- Large ribosomal subunit protein P2x
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- B3 domain-containing protein REM11
- AT3g20100/MAL21_14
- FCS-Like Zinc finger 5
- AT4g23680/F9D16_150
- B3 domain-containing protein At2g35310
- B3 domain-containing protein At5g18000
- B3 domain-containing protein At3g19184
- B3 domain-containing protein REM5
Sequence:
MADDSELYPRFFKVFLVESASESLMIPLPFMAFLADPLPKTVKLQGLGGKLWTVSLKKISGAAYLTRGWPKFAEEHELKNGEFMTFVYDGHRTFEVSVFDRWGSKEVRAEIQAIPLSDSDSDSVVEDEKDSTDVVEDDDDEDEDEDEDDDGSFDEDEEISQSLYPIDEETATDAAVFEGNLDVEALTNPHFPTTLKNRIYELLIPANVVKDNNLEFGSSIKYIDGEGTLVGLRGKWADKRVCFKGWDRICRRNRLKKHQDTVECELLHDDQKMVHSIRVHVLRRDA
Protein: Hemocyanin subunit B (Q8IFJ8)
Organism: Scutigera coleoptrata (House centipede)
Function: Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:12823556}.
Interaction partners:
Sequence:
MVAKWCVLAMCLLVAVGADKCPRATDQEAKQKRMLEVLQHVNKPYVAETKDPKIPAGSEDVFKHLGILEKHEVFSLFDERQWDEATTAAVYMLTAPSFDEFIDRAEIVRHRINEDMFYYAFSVAAVHRDDTRGINLPRIHEIYPDKFLKHKVIVEVKNSINSGQEDPLIDATHEFTDLRDPNSKLHYFLEDVGLNSHHYHWHVIHPAVWQESLEELTHQHKDRKGELFYFMHHQMVNRYDAERLSNGLPRSTTFENWNDPIETGYAPHLTIDRTGYRYQFRPDNLVVRDLPELTKNHMRQWRDRILYAVHRGEALAANGSSVSLRDERGIDVLGNMVESSLQSINRPFYGNVHCYAHVIAARIADPDGKYGEDNGAMYDVATSARDPLFYQWHKFIDNLFHEYKDALKAYSSEDLTYNDITIEEVNVQGEGGSPANTVTTFLENSIVHLDEGFSFTARGHARVKVQHLQHEGFNYQIKVNNAGGEHKVVFRVFLAPKYDEEHHEFDFNEQRGMAIELDKFVATVPAGSSTVEQHSSKSSVTQSNDNFYGSSATRSSENHCSCGWPDYLLIPKGNHQGVQFNVYVIATSYDEDHVESDESCHCGDSLSYCGALYDKYPDRRPMGYPFDRHADAQTFDEFKTKNMNSVTVTIKHTGEVKDA
Protein: Regulator of G-protein signaling (Q2LD94)
Organism: Pyricularia grisea (Crabgrass-specific blast fungus) (Magnaporthe grisea)
Interaction partners:
Sequence:
MDDTSRPDQVFKITSTQGIDHNNKPTAPSEVVNEKSHAALSSAHLHSTLPAPLPDTTAKPGSRKSLLLQQHQQQKSTTESTNAAPDSKPQRAGGIFAYAAAALDRTLSESRNIRSRPSLNRLSVSVLPESTTTTSSPRQPTGGNNGSSSPEKKARNRASVSNLRLSSLGTPPSQPYNDTDPSQPAPVHVQRLSNKMHQTSSRLLRMTDDDRPFTKDFKDLFATLIVSMLPLTPHRVRLTKIDHTFLSEDAINNLGSLKFSQSNRMPDPKDVARIVTTTTTTTFSMAKEMARSMLQRFLEARLIESADGKYQQVYTMRGTVWQLTPKGISILDSFASRNGIQDRQIPEVVGSSLAQLVTLERDPATDKLVKDFHTIEVIFGRFIGIHGPNVKSSVSSADSDSLSDYRDGLTGVKMAPERKVNGKIHKDTFTGKAASEWLMDCCTTVDRREAVEIASLFVEYELIEALQQDRSHIQQFPGCQVFQPTKHAIYHMTSKGKDMINGSVPRGRASEGDATHSATHRHGVARDSNTQRMDKILNDAALRLLFRENLRETHCEENLSFYLDVEEFVRLCRSAVRQAQLAQSSPANSAEAKKQALDGVKEVMAQAYGIYNAFLAPGSPCELNIDHQLRNNLATRMTKAVGQDSAMVETLQEVMALFEDAQNAVFKLMASDSVPKFLRSRRYEHLLKNYDFDSVSLESSPRVPERSQSRSQRL
Protein: Adenine nucleotide transporter 1 (F4JHS4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MASEDVKRTESAAVSTIVNLAEEAREGVKAPSYAFKSICKSLFAGGVAGGVSRTAVAPLERMKILLQVQNPHNIKYSGTVQGLKHIWRTEGLRGLFKGNGTNCARIVPNSAVKFFSYEQASKSFSNLCFFSFFSHSGILYMYRQRTGNENAQLTPLLRLGAGATAGIIAMSATYPMDMVRGRLTVQTANSPYQYRGIAHALATVLREEGPRALYRGWLPSVIGVVPYVGLNFSVYESLKDWLVKENPYGLVENNELTVVTRLTCGAIAGTVGQTIAYPLDVIRRRMQMVGWKDASAIVTGEGRSTASLEYTGMVDAFRKTVRHEGFGALYKGLVPNSVKVVPSIAIAFVTYEMVKDVLGVEFRISD
Protein: Chloride channel CLIC-like protein 1 (Q5T1P5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
XKKREDYESQSNPVFRRYLNKILIEAGKLGLPDENKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSPDQGSTYSPARGVAGPRGQDPVSSPCG
Protein: Chloride channel protein 2 (F1Q5F4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine membrane {ECO:0000256|ARBA:ARBA00004332}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004332}.
Interaction partners:
- Family with sequence similarity 131 member A.
Sequence:
MARDRAPQRVLQYQQTLMYGRYTQELGAYAKEEAARLREDGGLRRTTSVRGQAPELLEYEKDPCAKCQVCTSRCKKFLISRVGEDWIFLILLGLLMALVSWAMDYTIAFCQQAQKWMYRGLHSNMLLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTFKTFVAKVIGLTCALGSGMPLGKEGPFVHVASLCAALLSKFMALFGGIYMEEPFEGNKNELRNTEMLSAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNKDEETITALFKTRFRLDFPFDLQELPAFAVLGIASGFGGALYVYLNRIIVESMRKQKTINKFLLKKRLVYPAVVTLLISTLTFPPGFGQFMAGQLTQHESLVALFDNLTWYKQGVAEEFEYSSHVPQAWKHPQVSVFITLLLFIVMKFWMSAVATTMPVPCGAFMPVFLIGAAFGRLVGESMAAFFPDGIHADSTVYPIVPGGYAVVGAAALSGAVTHTVSTAVIVFELTGQISHILPVMIAVILANAVAQSLQPSLYDSIIRIQKLPYLPELGWGQEKYNIRVEDIMVRDVRYITLSSSYRDLQEALVTGQLKTLALVESKESMILLGSIERSQLQSLLSQQLGRPRRLEYLRERAQDNGTHVPTFTPDSPPKAGRGVRFLISTEESSYSPTLTNSQIPLKSALKTVSAISNTDSLNSSPNLSCGEPVKELVESNAGPMAPKRSRRPKRVKIPMADTADVEDDMSTAEIAEWEEQQLDEAVNFNNCKIDPAPFQLVERTSLHKTHTIFSLLGLDHAYVTSTGRLVGVVSLKELRKAIEGSVTVTGVKVRPPLASFRDSGNSSSVSEVTELHKLWSRHKSLSLPREINLPDLDDQTEQPSEGSLVNETECTELSSQNSPLHTDDQSELPYADTSPQDEPLSQLPCDCPEVEESESVGEHCPESTVVVGDGNPSPSDGQPE
Protein: Protein-arginine rhamnosyltransferase (EC 2.4.1.-) (EF-P arginine rhamnosyltransferase) (E6MVV9)
Organism: Neisseria meningitidis serogroup B / serotype 15 (strain H44/76)
Function: Protein-arginine rhamnosyltransferase that catalyzes the transfer of a single rhamnose to elongation factor P (EF-P) on 'Lys-32', a modification required for EF-P-dependent rescue of polyproline stalled ribosomes.
Interaction partners:
Sequence:
MNTPPFVCWIFCKVIDNFGDIGVSWRLARVLHRELGWQVHLWTDDVSALRALCPDLPDVPCVHQDIHVRTWHSDAADIDTAPVPDVVIETFACDLPENVLHIIRRHKPLWLNWEYLSAEESNERLHLMPSPQEGVQKYFWFMGFSEKSGGLIRERDYCEAVRFDTEALRERLMLPEKNASEWLLFGYRSDVWAKWLEMWRQAGSPMTLLLAGTQIIDSLKQSGVIPQDALQNDGDVFQTASVRLVKIPFVPQQDFDQLLHLADCAVIRGEDSFVRAQLAGKPFFWHIYPQDENVHLDKLHAFWDKAHGFYTPETVSAHRRLSDDLNGGEALSATQRLECWQTLQQHQNGWRQGAEDWSRYLFGQPSAPEKLAAFVSKHQKIR
Protein: cGMP-dependent protein kinase (EC 2.7.11.12) (A0A8I6ATM1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF
Protein: Hexokinase (BmHK) (EC 2.7.1.1) (A0A0K0JFP3)
Organism: Brugia malayi (Filarial nematode worm)
Function: Active against glucose, fructose, mannose, maltose and galactose.
Interaction partners:
Sequence:
MLGLLTITSVFRNWRNSLQRKEDYDECHMRGINNENEISGKSEKNFKLDEPPISLETVMAEFKLSNETLRRMMAHMSRNMDKGLEGGPENSTISMLPSFVPELPNGTEEGRFIAMDLGGTNLRVMLMDIKPGEELKTEQFNTRIPNWAMRGTGEQLFDYITKCLAEFLIEKGIENDGLPVGFTFSYPCDQKSLRSATLLRWTKGFETTGVVGEDVVELLEQSIARRGDIKVEVVALINDTVGTMVAAAHESGGECHIGVIIATGTNASYMEDTSKIKYGLSKAIAAYNYPEMIIDTEWGGFGDRSEADYILTQYDKIVDSRSEHPGVNTFDKLVGGKCMGEVVRVVLEKLTRARVLFNGKGSDALFQQDSFPTKYISEILRDESGSYVHTRDILGELGIDHYSFSDMLLLREVCVVVSRRSANLGAAAIACVLNRVRKQNMVVGIDGSTYKYHPFFDFWVHDKLKELVDPGLKFKLLQTADGSGKGAALITAIVARLKKRNLKQQQQQQQQQQQHVTMVEQNVVEQIAETKGSREQFMNGNQKINLVTNDIPIYDSFNGDIENGVIHLSTDH
Protein: Integral membrane metal-binding family protein (DUF2296) (F4JR68)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- ER membrane protein complex subunit 3
Sequence:
MAQEQEGAVVEKGEPNDSSAAAVAATATATADSVKKKQNGFFSRLWNGIFRVRGDDFEKRLQYISREEATVLSRMKRRSISWRKLTRNLIVSSVLFEIIAVGYAILTTRTEDLDWRMRSFRILPMFILPAVSALAYSSIVSFSKMFDRRDQKTLEKLRAERLAKINELKERTNYYTTQQLIQAWHSHATKERSMFADLKRLTTACRAGANRIVLMQRYDPDPAAKAAAATVLASKLGADSGLKVYLGDESQLDPSSGKSNDMEVNQSRGLRNRRQPNTRPHGSGSTSTHHSDDESHHSGTSERFPGTTEQNQQMLVEHYSPQGYAAHDGSWISRIAALLVGEDPTQSYALICGNCRMHNGLARKEDFAYITYYCPHCNALNKPKHSEENVLLPAISASPITDSLPLIETSEVVNSSSSSSERGSSPTPEIKEEAAITETGTPS
Protein: Uncharacterized protein (Q385I0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Fungal lipase-type domain-containing protein
- Rhodanese domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- 39S ribosomal protein L28
- Uncharacterized protein
- Uncharacterized protein
- Ribosomal protein L9 domain-containing protein
- Uncharacterized protein
- tRNA/rRNA methyltransferase SpoU type domain-containing protein
Sequence:
MMHLSLQLCKPKTLAHMFRKLKLAGAHPDVLWAVDAQKAQHNSEEMIRLETMMHQRSTPGASNNRQSTAESFTFWLTDNQQQPRAFAAGRSSLRSVSCTINPIAPTRTIKQQLTQLFRDAGVYEDFEIGGEGVEMNLESVLRQADERQEEHLQQSGTLYIRGDKSIEMLRRFGVLLIIEEEGVTYLVTLPDVLDKPVDDTPSTYTPARSLIGPDGEIDPRVQDYIRDRGLRAFDLRMAGSHSSVERFVSAFERLERLYEVHRGRAMRSCVCLVLSIKAPKCYVAEDGCIVLSVQQMPMWEEFLLSLPQEVWQSCVQMHRDWRVGNAPKFHERQRQLMKVADMFHFFRVRLDGCIGSQTDWQQQFILSMQKEEMIVRNAVKKYNLKSELLKRRGEICVSNTLRSAVDPTKEIGYRIGGDGRVYFNHSAMNTGQMLRALKDNLRRLETFQKQHDDAVATLEHMSRSIPVDFSVDTNWKLREEGNLVSCLQRFVRTIKANQTQLSAFLTMLLKKRDGAGAPKKRMVWIISERFDTLPSGVVYIPWDVDFDSIKKHLLPSG
Protein: Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) (Q9XSR0)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q14116}. Secreted {ECO:0000250|UniProtKB:Q14116}. Note=The precursor is cytosolic. In response to inflammasome-activating signals, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1, CASP4 or CASP5 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10. {ECO:0000250|UniProtKB:Q14116}.
Interaction partners:
- Interleukin 18 receptor 1.
- PYD and CARD domain containing.
- Interleukin-1.
- Caspase-1
- Interleukin-10
- Interleukin-6
- Interleukin-1 beta
- RELA proto-oncogene, NF-kB subunit.
- Interferon gamma
- Nuclear factor NF-kappa-B p105 subunit
Sequence:
MAANLIEDNCINLVKMKFVNNTLYFKAESDEGLESDYFGKLEPKLSIIRNLNDQVLFVNEGNQPVFEDMPDSDCTDNAPHTIFIIYMYKDSLTRGLAVTISVKYKTMSTLSCKNKTISFQKMSPPDSINDEGNDIIFFQRSVPGHDDKIQFESSLYKGHFLACKKENDLFKLILKDKDENGDKSIMFTVQNKS
Protein: YbtA (Transcriptional regulator YbtA) (YbtA protein) (Q56951)
Organism: Yersinia pestis
Interaction partners:
- Lipoprotein inner membrane ABC-transporter
- Irp1 protein
- Previously sequenced as Yersinia pestis yersiniabactin biosynthetic protein Irp2 TR:Q9Z399
- YbtQ
- Putative signal transducer
- Pesticin receptor
- Previously sequenced as Yersinia pestis yersiniabactin biosynthetic protein YbtU TR:Q9Z3C6
- YbtT protein
- Salicylate synthetase
- Salicyl-AMP ligase YbtE
Sequence:
MTESPQTQSEISIHQLVVGKPANDGNIPAQCELLRCSLQEGMDILLWRGHFARPETLQLHDDLGRINFSCILEGTSRFAIQGLRRHTDWELARNRHYITHTPDCRGSASYCGRFESITLSFSPETLALWVPDISAVIKNKIDSHCCCQQQRCNAETHLTAQALRHALMRMHGGFSHEQKPSTLWLQGQSLVMLSLVLDEHREDASCLSCHFNPMERQKLLRAKDLLLADLTQAPGVAELARESGLSVLKIKRGFRVLFNNSVYGLFQAERMQEARRRLANGNTSVMTVAADLGYANASHFSAAFQKQFGVTPSTFKRVM