wanglab/gogpt-training-data huggingface dataset:
Protein: Mitochondrial intermembrane space import and assembly protein 40 (Mitochondrial import inner membrane translocase TIM40) (P87059)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.
Interaction partners:
- Mitochondrial FAD-linked sulfhydryl oxidase erv1
- Cytochrome c oxidase copper chaperone
- Mitochondrial import inner membrane translocase subunit tim10
- Mitochondrial import inner membrane translocase subunit tim9
- FAD-linked sulfhydryl oxidase erv2
- Mitochondrial import inner membrane translocase subunit tim13
- Rsm22-cox11 tandem protein 2
- Rsm22-cox11 tandem protein 1
- Mitochondrial import inner membrane translocase subunit tim8
Sequence:
MFAKNLLFRFPKCIRINGYNNMRRSLLQRNGFQAGICRKFGTATKTDVWKGRFLPIVSGVAAASLTAGYLLGKNTSNASSSQDNDHPVVGEHVHTETQSYNEPYMQRHRIEDAIEKKMTSETQPSTDEKGRKVSATENSAPKKTDKEKSSGETAGNILREQIATGKDDDEYARKFEEVEEESSEESAFNPDTGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSKSEPKGMECLDKFQAMQACFQKHPEIYQDMVGESEEEDAETNEKPSTTSDENNQPQSPPSDNASNPEEDVMNMEKEIVNLTPMSVIKEI
Protein: Ribosomal protein S3A (D6RED7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLF
Protein: Max-like protein homolog 2 (Q9TZ70)
Organism: Caenorhabditis elegans
Function: Transcription factor. Binds to the E box motif 5'-CACGTG-3', probably in a heterodimeric complex with mml-1. Involved in modulating longevity in response to TOR signaling, dietary restriction, the decline in protein homeostasis associated with normal aging, germline signaling and the insulin-like signaling pathway. Plays a role in autophagy. Involved in regulating migration of the ray 1 precursor cells in the male tail, acting in concert with Wnt and semaphorin signaling pathways. Regulates transcription of genes encoding extracellular matrix (ECM) components which may contribute to the substratum required for migration of the neighboring ray 1 precursor cells. Required for resistance to oxidative stress. Involved in promoting infection by the microsporidian pathogen N.parisii, probably acting independently of its canonical partner, mml-1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:17826759}. Cytoplasm {ECO:0000269|PubMed:27001890}. Mitochondrion {ECO:0000269|PubMed:27001890}. Note=Only sporadic mitochondrial localization. {ECO:0000269|PubMed:27001890}.
Interaction partners:
- Protein WBSCR14 homolog
- Max-like protein 1
- Mad-like protein 1
- Protein mxl-3
- RRM domain-containing protein
Sequence:
MSRSRSAAASSSQKPDDMDLMSPDGSASSPSAPNTPATNSGGFSSDRKKATHLRCERQRREAINSGYSDLKDLIPQTTTSLGCKTTNAAILFRACDFMSQLKTDISDADKQLAQLNAQAAALEMIASEYEQMASSVPDAGQSTIQVKMLQLLLDDCFTSFSSQVDFTTYATITRTLLSWVESLAPNAEPFKSTAGKMVTMPFTSP
Protein: Formin HOmology Domain (A0A0K3AU72)
Organism: Caenorhabditis elegans
Interaction partners:
- FH2 domain-containing protein
- CLASP_N domain-containing protein
- Formin-homology and zinc finger domains protein 1
- Profilin-3
- Actin
- Profilin-2
- Profilin-1
- Rho GTPase-activating protein 20
- Nuclear anchorage protein 1
Sequence:
MRSHCSPATASYAPPVVKSRGLRTYDIDVGGSAPRASSLRATPIDLDFPVIQKSSIAFAKPTTISTLEPTSFAKPYIPSGYLSSSVKTANQEVFAKPYIPSTSSECFAKPYSNLKSSEELTKPYEPSTVSAKPYISSSEASSTKPYSSSFFSKPKEPEVKVQPSSSMFSRKMFTPSTSSAPKPYEPSTSSTFQFPEIKPKWYTSPVAEPLIRPYNSKPIDTPVSYKPSTTKAYVSPFRESEVPPISSLSTHVSDESLARNASILSVSNELPLIVKPLRRNFSEQRRTTLVEPPAIPMPSESFCSSLPRNFHRPTVLHCAAPVVIGTDTSEAIPFIDEDPPPSSLPAVPSQSSYIAPPTIKPSVQSNSSLHRREDSGYRSMENIRKMSIPEAAQPVVAMITPYTSKEPTSSKVESQDSVEDFHEDPFDWGDEYLNSGAKRRCSLVLRTQTSLRVKTIIDKLLNCSGRDQRRALFSLKQIFQDDQDLVHEFVQNQGLDCMIRLGRTADQNHQNYILRALGQLMLYVDGMNGIIAHNGTIQWLYELLDSPLYIDEERKEMSPFRLEWFRLVVKTALKLLLVFIEYNDNNALLVLTAIQTVDKSKGQADWSGLMKVLTEKDSPDAETLVYGMTVVNKALHGIPDRDTYYDAVDTLDTLGMEDAIKSMSRSNNKELEEQCRLYERELKEEDERGDNDEDVVKMRSSADTFKNQSRRSSQGSHDSAITMGSEEDGSRCSPDRDKQTPSPAPSSHIIPSSPLIPPTPSACNTLERRSRAFEHEMPEDRETALEKLNRSLHNRREMEKQKAEEARRKEAERIEEIERMRQQAEERRRREREEEERRKREEEEAEKQRKREEREVRFSKNDISPTTSSGVADDKKATMRRRHDEARRRQLEHEQFTANRTLFNKIDIGAAPRIPSPVSPTVSSWQPPVREDIQPTTSTATNNNDIGSIRSKNIPAPIQLVQENQENEIPKETDESESSKSVKAPPPSFPTLFSPTESKTMDFSEVAPQEPEPEKVAPPPPRAKIEDTGSGNSFADMLQKRAARSAEANRGTFEKKESEAEMQWKKAAENLEKRPLIINDLDFSQFHGVEYQQDPLQLARMAKMKEMAENGMRGGPVGVGVPPPPPPPSAIPLPPRLQGGIPPPPPLGIIPPPPPPGNLLMNGINRGDISPAANKGVLKLHWKPATVEQPDGIPSLKQKGSFWNTVDGAVPTFDAKKIVQLFETKKEKEAPVKKVAETKTQTLSVLPLKRSQAINIGLTKLPPINVIPAAIMKFDSLVLNKDGIEKILKTMMPSPKEIEEIEIKAAENPEMTLGNAEQLLLKLSQIPCLLERLRLWLFTLDYKNSEKDIAEPLMDMQLAMKEMEESRTFKVAMGMLLAIGNSLSGTDIKGFYLDYLTKASEVKDPVYKHTLTYHLAEYMVEHFSEGTDLYSEFGAVARSARVDYKELLDNLIRLEKDCKSSWECLATISKNDNSNMKQKINDYLADVAQRIHQLKAIYTVTKNRWHSFLLYFGYSVDEIPNQTPNDVFKMVTEFSLEYRTTRDKILQQRKRLAEKRERNKTRGKIWALEGSSAEGGAGDAAPLRRRNHGPGTVAPVQNSQQRHDDMSKMLASMADDNNSLRRRPAGSNGVNGRNFGGSVKDLVDTESPEDEILNGLVKAATLQTDPRDQRRRARQFNRKSLRRTRTLKMVDGQLETNY
Protein: Hemolin (Hemocyte aggregation inhibitor) (Protein P4) (P31398)
Organism: Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Function: Insect-immune protein with antimicrobial activity. Forms a protein complex at the bacterial surface. Can inhibit hemocyte aggregation.
Subcellular location: Secreted {ECO:0000269|PubMed:16731347}.
Interaction partners:
Sequence:
MVSKSIVALAACVAMCVAQPVEKMPVLKDQPAEVLFRESQATVLECVTENGDKDVKYSWQKDGKEFKWQEHNIAQRKDEGSLVFLKPEAKDEGQYRCFAESAAGVATSHIISFRRTYMVVPTTFKTVEKKPVEGSWLKLECSIPEGYPKPTIVWRKQLGEDESIADSILARRITQSPEGDLYFTSVEKEDVSESYKYVCAAKSPAIDGDVPLVGYTIKSLEKNTNQKNGELVPMYVSNDMIAKAGDVTMIYCMYGGVPMAYPNWFKDGKDVNGKPSDRITRHNRTSGKRLFIKETLLEDQGTFTCDVNNEVGKPQKHSVKLTVVSGPRFTKKPEKQVIAKQGQDFVIPCEVSALPAAPVSWTFNAKPISGSRVVASPSGLTIKGIQKSDKGYYGCQAHNEHGDAYAETLVIVA
Protein: Uncharacterized protein KCNJ5-AS1 (KCNJ5 antisense RNA 1) (Q8TAV5)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MLTRLVLSAHLSSTTSPPWTHAAISWELDNVLMPSPRIWPQVTPTGRSASVRSEGNTSSLWNFSAGQDVHAIVTRTCESVLSSAVYTHGCGCVRSATNITCQSSGQQRQAARQEEENSICKAHDSREGRLGYPLSAHQPGSGGPN
Protein: ABC-type bacteriocin transporter (A3DCU1)
Organism: Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Bacteriocin-type signal sequence-containing protein
- Efflux transporter, RND family, MFP subunit
- ABC transporter related protein
- Radical SAM domain protein
- Spermidine/putrescine import ATP-binding protein PotA
- Hemolysin A
- Translational regulator CsrA
- Exodeoxyribonuclease 7 large subunit
- ABC transporter related protein
- ABC transporter transmembrane region
Sequence:
MLRRLFKKKYVCVRQYDLTDCGAACLSSIAQYYGLKMSLAKIREMTGTDTQGTNAYGLIHAAKQLGFSAKGVKASKEDLLKDFRLPAIANVIVDNRLAHFVVIYSIKNRIITVADPGKGIVRYSMDDFCSIWTGGLVLLEPGEAFQKGDYTQNMMVKFAGFLKPLKKTVLCIFLASLLYTALGIAGSFYIKFLFDDLIKFEKLNDLHIISAGFAVIFLLQIFLNYYRSILVTKLGMSIDKSIMMEYYSHVLKLPMNFFNSRKVGEIISRFMDASKIRQAISGATLTIMIDTIMAVIGGILLYIQNSSLFFISFIIILLYGIIVTVFNKPIQNANRQIMEDNAKLTSALVESVKGIETIKSFGAEEQTEKSTRDKIETVMKSSFKEGMLYINLSSLTGIVAGLGGIVILWAGAYNVIKGNMSGGQLLAFNALLAYFLTPVKNLIDLQPLIQTAVVASNRLGEILELATEKELREDSDDFVISLKGDIEFRNVDFRYGLRKPVLKNINLTIPKGKTVAIVGESGSGKTTLAKLLMNFYSPEKGDILINGHSIKNISLELIRKKIAFVSQDVFIFSGTVKENLCLGNENVDMDEIIKAAKMANAHDFIEKLPLKYDTFLNESGANLSEGQKQRLAIARALLKKPDILILDEATSNLDSITENHIKDAIYGLEDDVTVIIIAHRLSTIVNCDKIYLLKDGEIVESGSHTELIALKGCYFKMWKQTENTLAS
Protein: ARL17 protein (Q9BVU5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
GARSPGSTHQGSLASGVLPIKCSHVEFGMWKGGRSHPFLPHSSRCAGSGGQLDSILPHQSPAWGPWGCKDLSSGFPSFLTSSILWKSAVVREPHISPHQAPPYKTSDCIT
Protein: RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Q80WA4)
Organism: Rattus norvegicus (Rat)
Function: Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons. Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. Binding to 5'-YCAY-3' clusters results in a local and asymmetric action to regulate spliceosome assembly and alternative splicing in neurons. Binding to an exonic 5'-YCAY-3' cluster changed the protein complexes assembled on pre-mRNA, blocking U1 snRNP (small nuclear ribonucleoprotein) binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhanced spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Autoregulates its own expression by acting as a splicing repressor. Acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer. Acts to regulate a novel glycine receptor alpha-2 chain splice variant (alpha-2N) in developing spinal cord.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9JKN6}.
Interaction partners:
- Polypyrimidine tract-binding protein 2
- Polypyrimidine tract-binding protein 1
- ELAV-like protein 4
- RNA binding protein fox-1 homolog 2
Sequence:
MAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLIQGTIEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQVKIIVPNSTAGLIIGKGGATVKAIMEQSGAWVQLSQKPDGINLQERVVTVSGEPEQNRKAVELIIQKIQEDPQSGSCLNISYANVTGPVANSNPTGFPYANTAEVLPTAAAAAGLLGHANLAGVAAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFALGSLAAATAATNGYFGAASPLAASAILGTEKSTDGSKDVVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFVPGTRNRKVTITGTPAATQAAQYLITQRITYEQGVR
Protein: Mitochondrial fission factor (A0A0A0MS29)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|RuleBase:RU368040}; Single-pass type IV membrane protein {ECO:0000256|RuleBase:RU368040}. Peroxisome {ECO:0000256|RuleBase:RU368040}.
Interaction partners:
Sequence:
MQVPERIVVAGNNEDVSFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPPTTPQNEEIRAVGRLKRERSMSENAVRQNGQLVRNDSLVTPSPQQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRYGISNIDTTIEGTSDDLTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR
Protein: AP-1 complex subunit gamma (A0A8I6AE72)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00029433}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKADCASGVFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVSRLELIPWNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPSEIVQTNGETEPAPLETKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAPTSKPASAGGELLDLLGDITLTGAPAAAPTPASVPQITQPPFLLDGLSSQPLFNDIAPGIPSITAYSKNGLKIEFTFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGTITQVIKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSWQ
Protein: Methionine aminopeptidase 1D, mitochondrial (MAP 1D) (MetAP 1D) (EC 3.4.11.18) (Methionyl aminopeptidase type 1D, mitochondrial) (Peptidase M 1D) (Q9CPW9)
Organism: Mus musculus (Mouse)
Function: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03174}.
Interaction partners:
- Electron transfer flavoprotein subunit beta
- Electron transfer flavoprotein subunit alpha, mitochondrial
Sequence:
MAAPIGVPLLVRGGCQRILSSPLNHIYLHKRSGSQQRRHFFFWRQRDISHSVVSPAAVSPAHPVPKRIKKPDYVTTGIVPDWGDSIEVKDEDQIQGLREACRLARHVLLLAGKSLKVDMTTEEIDALVHWEIIRHDAYPSPLGYGRFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDESGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISRITHQNGLQVCPHFVGHGIGSYFHGHPEIWHHANDNDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITPRGVEILTKLPQEA
Protein: SET domain-containing protein (Q585F5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Histone H2A
- Histone H3 variant
- Histone H3, putative
- Plastid-encoded RNA polymerase subunit alpha
- Histone H2A
- Histone H4
- Histone H4
- DNA-directed RNA polymerase subunit beta
- TFIIS N-terminal domain-containing protein
Sequence:
MVLGGVVGGRITANRKSVLQRLNTVTTTHLLCNRLCSGCAVTSLSGSDSEKPKSQRLPRRTKRTNYADREQLMFPDLFVASSEGEAVSCGSWESLDEGVMQPPQPHAAASSLRLSAFVLGALAMPLVGPITYGILNAMAYVGYTMGRVSFYTRYSVAPPLSTSGGNSTSATPSPVLLRTSLSSPMDVEASIQQLIAAGAYAQAAALSTTTVHQAECANSRESLTASDNSGTVSAENIFLENLNGTPYFRGLLQGTTLDCIRVGSSPIHSRGLFTTKALPRGTRVVVAPQRTYMDAAQLVLLLGDTHTRLPDTFHYTHPTGSLMELVTQPLPHHLMNHSCEPNCCCGLSKEFWPAAAATGEYSECKEVLSRIENFPYFGDANSFFTTRDVPAGSELTISYSHRVAPLFYGENALKKYFVVCRCGSSNCRHFVYKQTDEVSQYFAGRKHCKDKNGILSRFICNGGNNVRVNGNRNIGDDSIKEVGKLLRMGYDDETVFLSLLSSRKPLLRYMQAHLAASRRSATKRELLMCYRHVFKFLNEASPVD
Protein: Receptor-type tyrosine-protein phosphatase (EC 3.1.3.48) (Q1MTF9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase delta-like
- Otogelin-like.
- Rho GTPase-activating protein 5
Sequence:
MMVLFLVSAALISNSSSHGNLTTESPAPQGSHVLASGLVTSLLLVIFLLLVAYILRFREQRKDLVTSVDKKLPNGFLEDQEQTVVLLPRSPSPSKRYFPIPLDSLEEEFRLRMADDGKLFREEFNSLPCGFGCGTFEEASREENREKNRYPNILPYDHSRVLLSHIDGYMGSDYINASYIDGYREKNKFIAAQGPKPETVGDFWRMVWEHKCATIVMLTNTRERKEEKCYQYWPEQGCWIYGCVRVAMEDFTVLVDYTIRKFCHAAEGCRPPRLVTQLHFTSWPDFGVPLSPIGMLKFLKKVKSVNPAHAGPIIVHCSAGVGRTGTFIVIDAMMDMMHAEGRLDVFGFVSRIRKQRCQLIQTDMQYSFIYQALLEHYLFGDTELDIASLEGHLHKLHNTHTNMDRVGLEEEFRKLTNVRIMKENMRTGNLPANMRKNRVLQIIPYDFNRVILSMKRGQEFTDYINASFIDGYRQKDYFIATQAPLAHTVQDFWRMVWEWKCHSIVVLTELKEREQEKCVRYWPAEGSVSFGDYVLELKRDTLCETFSIRDMLLSYASEKQTRLVRQFHFHGWPEIGIPSDGKGMIDIIAAVQKQQQQSGNNPIVVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQTVKSLRTQRPHMVQTVEQYDFCYRVVQDFVDIYSDYANFK
Protein: Acid-sensing ion channel 4-B (ASIC4-B) (Acid-sensing ion channel 4.2) (Amiloride-sensitive cation channel 4-B) (ZASIC4.2) (Q708S3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable cation channel with high affinity for sodium.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17686779}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sodium/hydrogen exchanger
Sequence:
MPIEFVCKIKFAEGEEAKGASTEGGGTGMLDEGLRRQKEGMADLASFASSSSLHGLARALGTSERLGFRQTLWGLALLVSLGLFLYQATWSAATYLERPHLAALREETRRELTFPAITLCNVNRFRFSALTDADIYHLANLTGLPPKSRKGHRPSELQYPPPNMLDIFQRTGHQLEDMLKSCNFSGQNCSSEDFSVVYTRYGKCYTFNGNKTSPKRVRQGGTGNGLEMMLDIQQDEYLPIWRETNETTLEAGIRVQIHSQNEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRASSEPVIPGYDTYSVSACRLHCESTQVQRECNCRMVHMPGDADICAPSKIKCVDKALASLQKSTGDSCPCETPCNLTRYGKELSMVKIPSRGSARYLSRKYQKSEEYIRDNFLILDIFFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIYEVAKNKIKQLLKPKKSQKQTNQRNLIQEQIQRTKNLREQNLKAQLTAGAIATVRFEEVKVKAANDVAQPHSAHPTSVLPNHHNAQQAVQQDFAC
Protein: Cytoplasmic polyadenylation element binding protein 3 (A0A8I5Y6H1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MQDDLLMDKSKTQPQSQQQQQQQQQQQQQQQQQQQQRQQQQQQQQQLQPEPGAAEAPSTPLSSETPKPEDSSAVPALSPASAPPAPNGPDKMQMESPLLPGLSFHQPPQQPPPPQEPAAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPQPPQPAQPPQAQPSQQRRSPASPSQAPYAQRSAAAYGHQPIMTSKPSSSSAAAAAAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGKHYPPSGPPMSFADIMWRNHFAGRMGINFHHPGTDNIMALNSRSSLFPFEDAFLDDSHGDQALSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRQVPFRWS
Protein: Uncharacterized protein (Q728Z2)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Uncharacterized protein
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta
- DNA gyrase subunit A
- Oligopeptide ABC transporter, permease protein
- FG-GAP repeat protein
- Oligopeptide ABC transporter, permease protein
- Zinc finger/thioredoxin putative domain-containing protein
- DNA-directed RNA polymerase subunit beta'
- Uncharacterized protein
Sequence:
MPASGRTAYDTPRQGVTQGITMTDTAYLGQTVDVILGQEFLTWLWYRSESRNGSFETEDGRNFGVFMEQRIAVQGGEGESLETATVSGSMSQLREARLGLSTGKKVSRALIRIERDADSWLLTLKAEDFALNSLKTPVIEKDGEDDDPDARFLEKMYLIDTCLGFLDEVYRQFLAVRLSPRWNDEVRDLRVWMERTA
Protein: H2.0-like homeobox protein (Homeobox protein HLX1) (Q61670)
Organism: Mus musculus (Mouse)
Function: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- T-box transcription factor TBX21
Sequence:
MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFALDPAAVKKPSFCIADILHAGVGEPGPAAEGLVGASAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAFHQHLPQQSPTQQQQPQQQPPPPPRAVSLQPPTSGTRVVPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLAGLQPSAGQFFASLDPISEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGVPAEGEREERSPSRSEGEAESESSDSESLDMAPSDTERTEGTERSLHQTTVIKASAAGALITASSSTSGSSFSFSSTSSLGSGNTHVGSASSLGGNCSELPSAHQPSVTSSPQSPEIAQAPLAGL
Protein: Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Rho-interacting, serine/threonine-protein kinase 21) (P49025)
Organism: Mus musculus (Mouse)
Function: Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Probable RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9792683}.
Interaction partners:
- Kinesin-like protein KIF14
- Transforming protein RhoA
- Anillin
- Abnormal spindle-like microcephaly-associated protein homolog
- Protein regulator of cytokinesis 1
- Kinesin-like protein KIF23
- Cyclin-dependent kinase inhibitor 1B
- Rhophilin-1
- SRC kinase signaling inhibitor 1
- Inner centromere protein
Sequence:
MLKFKYGVRNPPEASASEPIASRASRLNLFFQGKPPLMTQQQMSALSREGMLDALFALFEECSQPALMKMKHVSSFVQKYSDTIAELRELQPSARDFEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNNLYLVMEYQPGGDFLSLLNRYEDQLDESMIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGEIKLVDFGSAAKMNSNKVDAKLPIGTPDYMAPEVLTVMNEDRRGTYGLDCDWWSVGVVAYEMVYGKTPFTEGTSARTFNNIMNFQRFLKFPDDPKVSSELLDLLQSLLCVQKERLKFEGLCCHPFFARTDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSVCQLSPSGFSGEELPFVGFSYSKALGYLGRSESVVSSLDSPAKVSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQSKEPGSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDVSPNIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLDEFLDKNDHSLAPAVFASSSNSFPVSIVQANSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAYLEIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEQHRVPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYRDREGRTELRRDKSPGRPLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV
Protein: Neurogenic differentiation factor 1 (NeuroD1) (Beta-cell E-box transcriptional activator 2) (Beta2) (Q60867)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation. Colocalizes with NR0B2 in the nucleus (By similarity). {ECO:0000250}.
Interaction partners:
- Transcription factor E2-alpha
- Achaete-scute homolog 1
- Paired box protein Pax-6
- Homeobox protein Nkx-6.1
- Transcription factor 4
- Insulinoma-associated protein 1
- Paired box protein Pax-4
- Homeobox protein Nkx-2.2
- Solute carrier family 2, facilitated glucose transporter member 2
- Cone-rod homeobox protein
Sequence:
MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDELEAMNAEEDSLRNGGEEEEEDEDLEEEEEEEEEEEDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNPDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSAEFEKNYAFTMHYPAATLAGPQSHGSIFSSGAAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD