wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger C2H2 LYAR-type domain-containing protein (Q57WD3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Uncharacterized protein
- 50S ribosomal protein L7Ae, putative
- Ribosome production factor 2 homolog
- Ribosome assembly factor mrt4
- 60S acidic ribosomal protein P0
- Ribosome biogenesis regulatory protein
- 40S ribosomal protein S15, putative
- Peter pan protein, putative
- RNA-binding protein, putative
- Ribosome biogenesis protein, putative
Sequence:
MVSFTCSVCQDVVKKPKVAGHGNMCRGASFACVDCMEVFDIHTVKGHTSCVTEVEKYQGKWRRNTSGGFQPQQQQNQKLNGHQKSANDSDDENHYGNGKSDSKGYINGNNAGRNGADKKMRRPAMQLSSDSDDDDDSWVKQKKKTSNKAGEAEKTTQSTDASSSLSSSSVVAAKAVSNVLITAATVYEAEGAEVRRGKRHRLEPLVLPRSVCSTEASDCVVPSFVLGSDDEVTKVVRWVLEDAAPATLNMKELARKLVECYEARLARKLRCVVESLIRRGKLRLEEGVVMMRDEEAG
Protein: Transcription factor bHLH51 (Basic helix-loop-helix protein 51) (AtbHLH51) (bHLH 51) (Transcription factor EN 57) (bHLH transcription factor bHLH051) (Q9XEF0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Probable transcription factor PosF21
- Transcription factor bHLH35
- Transcription factor BIM2
- Transcription factor bHLH27
- Transcription factor bHLH139
- Protein PLANT CADMIUM RESISTANCE 9
- Protein PLANT CADMIUM RESISTANCE 11
- Protein PLANT CADMIUM RESISTANCE 4
- PLAC8 family protein
- Protein PLANT CADMIUM RESISTANCE 5
Sequence:
MENSYDSSKWSDSTTPYMVSWSLQSESSDSDWNRFNLGFSSSSFGGNFPADDCVGGIEKAESLSRSHRLAEKRRRDRINSHLTALRKLVPNSDKLDKAALLATVIEQVKELKQKAAESPIFQDLPTEADEVTVQPETISDFESNTNTIIFKASFCCEDQPEAISEIIRVLTKLQLETIQAEIISVGGRMRINFILKDSNCNETTNIAASAKALKQSLCSALNRITSSSTTTSSVCRIRSKRQRWFLSSHYSHNE
Protein: Auxin transporter-like protein 1 (AUX1-like protein 1) (Q9LFB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Auxin efflux carrier component 3
- Auxin efflux carrier component 7
- Auxin efflux carrier component 4
- Protein PHYTOCHROME KINASE SUBSTRATE 3
- tRNA-specific adenosine deaminase TAD1
- L-tryptophan--pyruvate aminotransferase 1
- Holliday junction resolvase MOC1, chloroplastic
- ABC transporter B family member 19
Sequence:
MSGEKQAEESIVVSGEDEVAGRKVEDSAAEEDIDGNGGNGFSMKSFLWHGGSAWDAWFSCASNQVAQVLLTLPYSFSQLGMLSGILLQIFYGLMGSWTAYLISVLYVEYRARMEKQEAKSFKNHVIQWFEVLDGLLGPYWKAAGLAFNCTFLLFGSVIQLIACASNIYYINDRLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLGMTTYTAWYLTIASFLHGQAEGVTHSGPTKLVLYFTGATNILYTFGGHAVTVEIMHAMWKPRKFKSIYLMATLYVFTLTLPSASAVYWAFGDQLLNHSNAFSLLPKTRFRDTAVILMLIHQFITFGFACTPLYFVWEKAIGMHHTKSLCLRALVRLPVVVPIWFLAIIFPFFGPINSAVGALLVTFTVYIIPALAHMLTYRTASARRNAAEKPPFFIPSWAGVYVINAFIVVWVLVLGFGFGGWASMTNFIRQIDTFGLFAKCYQCKPPPAPIAAGAHHRR
Protein: H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1) (Q7ZVE0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit 2-like protein
- H/ACA ribonucleoprotein complex subunit 3
- H/ACA ribonucleoprotein complex subunit DKC1
- rRNA 2'-O-methyltransferase fibrillarin
- Nucleolar protein 58
- WD repeat-containing, antisense to TP53.
- Nucleolar protein 56
- NHP2-like protein 1
- Pseudouridylate synthase TRUB1
- Protein SHQ1 homolog
Sequence:
MSFRGGGGGRGGGFNRGGGGGRGGGFGGGRGGGFGGGRGGGFGGGRGGRGGFNRNQDYGPPEYVVALGEFMHPCEDEIVCKCVTEENKVPYFNAPVYLENKEQIGKVDEIFGQLRDFYFSVKLSDNMKASSFKKLQKFYIDPMKLLPLQRFLPRPPGEKGPPRGGRGGGGGRGGRGGGFRGGRGANGGGRGGFGGRGGGFGGRGGGGGGFRGGRGGGGGRGFRGGR
Protein: Gamma-secretase subunit APH-1 (APH-1) (A0A8J8XJD4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}.
Interaction partners:
Sequence:
MTAAVFFGCAFIAFGPALSLYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYRLLKKANEGLKSINPEETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSNALGPGTVGIHGDSPQFFLNSAFMTLVIIMLHVFWGIVFFDGCEKNKWYILLTVLLTHLLVSTQTLLSPHYEVNLVTAYIIMVLMGIWAFCVAGGSRRSLKLCLLCQDKDFLLYNQRSR
Protein: Caldesmon (CDM) (Q05682)
Organism: Homo sapiens (Human)
Function: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P13505}. Cytoplasm, myofibril {ECO:0000250|UniProtKB:P13505}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:P13505}. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250|UniProtKB:P13505}.
Interaction partners:
- Calmodulin-like protein 4
- Calmodulin-1
- Calmodulin-like protein 5
- Calmodulin-like protein 6
- Calmodulin-like protein 3
- Mitogen-activated protein kinase 1
- Myosin-11
- Mitogen-activated protein kinase 3
- Leiomodin-1
- Tropomyosin alpha-1 chain
Sequence:
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
Protein: Histidine-containing phosphotransfer protein (Q9ST01)
Organism: Zea mays (Maize)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|RuleBase:RU369004}. Nucleus {ECO:0000256|RuleBase:RU369004}.
Interaction partners:
Sequence:
MSAANQLAALVSNMYATGLLDDQFQQLQLLQDPSAPDFVSEVVTLFCQDGERIIEELAKLLEKPNVDFDRVDAFVHQLKGSSANIGAQKVKNTCIQFREFCQQKSRDGCLKVLETMRINFYELRGKFQTMLQLERQVNGFPPNK
Protein: Ras-related GTP-binding protein A (Rag A) (RagA) (EC 3.6.5.-) (Q80X95)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q7L523}. Nucleus {ECO:0000250|UniProtKB:Q7L523}. Lysosome membrane {ECO:0000250|UniProtKB:Q7L523}. Note=Predominantly cytoplasmic. Recruited to the lysosome surface by the Ragulator complex. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. {ECO:0000250|UniProtKB:Q7L523}.
Interaction partners:
- Ras-related GTP-binding protein D
- Ras-related GTP-binding protein C
- GATOR1 complex protein NPRL2
- Regulatory-associated protein of mTOR
- Serine/threonine-protein kinase mTOR
- GATOR1 complex protein NPRL3
- GATOR1 complex protein DEPDC5
- Folliculin
- Ras-related GTP-binding protein B
- Ragulator complex protein LAMTOR1
Sequence:
MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR
Protein: Zinc finger protein 408 (E7FAN3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- G patch domain-containing 3.
- Tetraspanin
- RCC1 and BTB domain-containing protein 1 isoform X1 and BTB
- Sterile alpha motif domain-containing 11
- Frizzled-4
- Norrin cystine knot growth factor NDP.
- Molybdate-anion transporter
Sequence:
MSTVTGRNEGSGNKRDSIHSALRSVPLGLTVGPSLAEDEQLGLWCVGRVLKKDTLLGLEEPGETISKEKEEGLQNASQSVYKREISDEVCWMQFACSAQSAEESNVSVLKVDGRLGLKVCRDIQPGTELLLWESHPEAVTEEETPQVETCENREQDEALEANTSDHFSGSPYLLQRVTQQDTKSPVTVKGLVQDNTICNSNVLEQNGMEESEAEHSDELPATEEIESINVSASQAQTSSQCLTPERSLRTSSRLASKPRKVHSSAKRIYKRHDPKNKPDLSSKKKLLNSKDDLMQPLTVKEESSTKQNGQDFPPFNIRERKYKCEECDKSFFQLCHLKKHKYTHQNQKPYTCTECGKSYSSHESFQAHLLMHRGQRPFKCEQCDKSYGLKRDLKEHQVLHSGEKPFVCDICGKAFARRPSLRVHREIHRTKEPDYQALKVKCPECDKELANSGSLRNHMRLHTGERPHICPHCNKCFRQRGNLQGHMRIHTGEKPYRCDHCDLRFSQVPELRRHLISHTGEVYLCPVCGKALRDPHTLRAHERLHTGDRPYKCEQCGKGYTMATKLRRHLKSHLEEKQHVCQVCGAKYSMMQSLQRHLQLHQPDSGHALPTRGRPKRLGQKEEEEPGRTESSGLEAGQAVACAQASDHLTMVTHTEGIILDSGTYQHGTIVLGKGAEKELDRIELSEDIIEIFISDENTNIVVQEQTSKGLSLQEQEVNAECTVEASSDCIVLPEQDANSCLVIIQGQDGLSSVAETVEIETVV
Protein: Aldose 1-epimerase (EC 5.1.3.3) (Q9LVH6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- beta-galactosidase
- Beta-galactosidase 2
- Alpha-galactosidase 1
- Alpha-galactosidase 3
- Alpha-galactosidase 2
- Beta-galactosidase 17
- Galactokinase
- glucose-6-phosphate 1-epimerase
- ADP-glucose phosphorylase
- Thylakoid lumenal P17.1 protein
Sequence:
MADQSKNTPEIFELNNGTMQVKISNYGTTITSLSVPDKNGKLGDVVLGFDSVDPYVKGLAPYFGCIVGRVANRIKEGKFSLNGVNYTLPINKPPNSLHGGNKGFDKKIWEVAGHKRDGEKPFITFKYHSADGEEGYPGAVSVTATYTLTSATTMRLDMEAVPENKDTPINLAQHTYWNLAGHDSGNILDHKIQIWGSHITPVDEYTVPTGEILPVKGTPFDFTEEKRIGESIGEVGIGYDHNYVLDCPDQEKEGLKHAAKLSDAASSRVLNLWTNVPGMQFYTGNYVNGVVGKGNAVYGKHAGVCLETQGFPNAINQSNFPSVVVKAGEKYNHTMLFEFSA
Protein: Centrin 4 (Uncharacterized protein cetn4) (F1R789)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- DNA repair protein complementing XP-C cells
- SFI1 centrin-binding protein.
- Pericentrin
- Dynein, cytoplasmic 1, intermediate chain 2a
- Serine/threonine-protein kinase PLK
- Dynein light chain
- Transcription and mRNA export factor ENY2
- Replication protein A3.
- Intraflagellar transport 88 homolog.
- General transcription factor IIH subunit 3
Sequence:
MASGFRKSSASANQRKKAGPKPELTEEQKQEIKEAFDLFDTDGSGTIDVKELKVAMRALGFEPKKEEIKKMIADIDKEGSGVIGFSDFLSMMTQKMSEKDSKEEILKAFRLFDDDCTGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEINEQEFLRIMKKTNLY
Protein: Probable ribonuclease P protein subunit 3 (EC 3.1.26.5) (P87120)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable ribonuclease P protein subunit 1
- Ribonucleases P/MRP protein subunit pop1
- Ribonuclease P/MRP protein subunit POP5
- Ribonuclease P protein subunit rpr2
- Ribonuclease MRP protein subunit rmp1
- Ribonucleases P/MRP protein subunit pop3
- Uncharacterized protein C16C4.19
- Uncharacterized protein C6C3.09
- Ribonucleases P/MRP protein subunit POP7
- Probable ribonucleases P protein subunit pop8
Sequence:
MFIDLNVVWPTLGVKDLNLVKTVKTLERLGYTAIALNYQYDGKLQNVIKNPIVKELYPEQKIKIYSRITLTIESMPQNKVLSNVTKEFDILAIRPIGDRLLQQTCSDLEFDILSIDFTQRLPFYLKHTFMGLAVSRDIGIEISYSSGLRDVSNRRNLITNATSLVRATRGRGIIVTSETRTPLECRAGFDVINLATFWDLKQDQARKSVGESCRSVLLHAETRRDTYRSILNGCH
Protein: F1F0 ATP synthase subunit k (A0A1D8PFD4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
- F1F0 ATP synthase subunit i
- ATP synthase subunit d
- ATP synthase F
- ATP synthase subunit 5
- ATP synthase subunit K
- F1F0 ATP synthase subunit h
- F1F0 ATP synthase subunit g
- ATP synthase subunit a
- ATP synthase subunit 4
- F1F0 ATP synthase subunit f
Sequence:
MGAAYQIFGKTFQPHQLALATLGSVVLLVLPKPWGPPSPTTPPIKASSPEEEKFIQEWLAKHTEEKH
Protein: Lysine-specific histone demethylase 1 (EC 1.14.99.66) (P110b homolog) (Suppressor of presenilin 5) (Q9XWP6)
Organism: Caenorhabditis elegans
Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). May be involved in H3 demethylation in mitotic cells including gut and embryonic cells. Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together with met-2, set-17 and set-26, required for transgenerational fertility. Plays a role in developmental growth and lifespan regulation in response to ultraviolet-induced damage.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- REST corepressor spr-1
- Histone-lysine N-methyltransferase set-2
- DNA N6-methyl methyltransferase
- Protein let-418
- Lysine-specific demethylase 4
- DNA N6-methyl adenine demethylase
- Histone-lysine N-methyltransferase set-25
- MYND-type domain-containing protein
- Lysine-specific demethylase rbr-2
- Probable histone-binding protein lin-53
Sequence:
MSSDTGSEYLDEEIRGDELGPSIDDNALAAAASAARLPFDRPTDHELAFFPELWEHKTAVEVFLLLRNSTLATWQYNPLKECTALDVRNNVFPPFNSDLDLIQNIVHYLSRHGLINFGRYVRSTKISRFLVRDRRSVIVIGAGAAGISAATQLESFGFDVIVLEARNCIGGRIHSFKSKSGEIMETGGDTLRKIEDSPMATLLHQVNFEEHGVFDFTSVFVEGRPLNEEKIHLFLDHYKSAHGALNYQAHQCEHRDDQGSFISRQQAYENLLSMCERGTLIKYYNFCKSLETVARAREHHFNQMKQLRMTALMAENQLKKMEEEGNLEQDPVLRRSLKRDIATSLEKFEEVADAFETADNHWQRLNEHPQAKQYMHPGSEFATFNFMLGFEEYLVGAQLEKVQFSCDSMQNKENGVAARLTEGIAELLTQLSEKRKLDIRLKHRVLDIDYSGFEHVLLKVQRENGDIEEMKAAFVVSTLPIGVLKKTIIADERAPTFTPSLPDKKVEAIRNIGCGSVNKCILEFDRVFWTANGGRNQFVTVSPNIKTRGSMNIWSSVPGSKVLCTYIVGEEAMLELPDDVIIQNAMINLQKAFGNNCPRAPISAHITRWHDDELAFGSGAFMSLRTETTSFDDVMEPLKTSDGMSRVYFAGEHTCSSYTSTIQGAWMSGARAAADISNDHIGIGFVDISGTRGQRGDEEEELLIEVDIDGKIPEKDENEAVADIPNAPNAPNAQKPEEIPKIAEEIELVAEAEKAEKAEVQLEPLVPTVE
Protein: Indole-3-pyruvate monooxygenase YUCCA8 (OsYUCCA8) (EC 1.14.13.168) (Flavin-containing monooxygenase YUCCA8) (OsFMOt) (Protein CONSTITUTIVELY WILTED 1) (OsCOW1) (Protein NARROW LEAF 7) (Protein RICE ETHYLENE-INSENSITIVE 7) (Q10RE2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in auxin biosynthesis. Converts the indole-3-pyruvic acid (IPA) produced by the TAA family to indole-3-acetic acid (IAA). Seems not able to use tryptamine (TAM) as substrate. Probably responsible for auxin biosynthesis in leaves and involved in the regulation of lateral leaf growth. Required for maintaining water homeostasis and an appropriate root to shoot ratio. Required for the inhibition of root growth by ethylene in etiolated seedlings. Functions downstream of the ethylene-response transcription factor EIL1.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:17619151}.
Interaction partners:
- Tryptophan aminotransferase-related protein 2
- Tryptophan aminotransferase-related protein 1
- Os01g0178000 protein.
- Probable aldehyde oxidase 2
- Probable aldehyde oxidase 3
- Probable aldehyde oxidase 1
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase ALDH2b
- aldehyde dehydrogenase
- Aldehyde dehydrogenase
Sequence:
MQGQQKQNAGGGGGDNASPCIVLDGPIIVGAGPSGLAVAATLRQHGAPFTVVERSGGVADLWTNRTYDRLRLHLPKVFCELPHVAFPPDFPTYPTKHDFLRYLHSYAARFAIAPLLRRTVTRAWYDHPASLWRVTTTTTSSSATSVITEYASPWLVVASGENAEVVVPKVKGRERFAGEALHSSEYRSGERFRGMRVLVVGCGNSGMEMCLDLCEHGAMPFMSVRSGVHVLPREMFGASTFGIAMKLLRWLPIKMVDRFLLLVARMVLGDTEKYGLKRPKLGPLEIKNITGKSPVLDVGAWSLIKSGNIKIVPEVESFSGNGARFVDGNEMAFDAVIFATGYRSNVPSWLQEDGELFTEEGKLRSSGSSSEWRWRGPNGLYCVGFSGRGLLGAGADALRAAADIAGRWQETQQAAANISSV
Protein: NADP-dependent oxidoreductase domain-containing protein (Q8BIV6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAAFVTLLTGAKMPIVGLGTWKSPPAKVREAVKVAIDAGYRHIDCAYVYQNESEVGEAIQEKIQEKAVKREDLFIVSKLWSTFFEKSLVKKAFQNTLSDLKLDYLDLYLIHWPKGFQSGNVFLPTDDKGSILSSKYTFLDAWEAMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGITITAYSPLGSPDRPSAKPEDPLLLEIPKIKEIAAKHKRTAAQVLIRFHIERNVVVIPKSVTPSRIQENIQVFDFQLSEEDMAAILSFNRNWRACGLFAASHNEDFPFHAEY
Protein: OCRE domain-containing protein (Q389H6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- WD repeat-containing protein 19
- Uncharacterized protein
- Intraflagellar transport protein A1
- Intraflagellar transport protein 80
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Intraflagellar transport protein-like protein
- IFT80/172/WDR35 TPR domain-containing protein
- Intraflagellar transport protein 122 homolog
Sequence:
MGCGDSKVRQGGPSRPPPPRGGPNSASTKVEGRANGPNEETSRVESKGSAPPEPEVNSTPVPTKPLGNGVDNSGAEKTNAPPTGSAPPAQNCSQQIELDDEGNALVLPKGEWVRTEGTPFYYSDAENLYFHPPSCQFYDPTNEMWYDPEQDEWYRDDDPAE
Protein: proton-translocating NAD(P)(+) transhydrogenase (EC 7.1.1.1) (Q18031)
Organism: Caenorhabditis elegans
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}.
Interaction partners:
- NAD kinase 2, mitochondrial
- NAD
- Nicotinamide-nucleotide adenylyltransferase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Glutamine-dependent NAD
- NAD-dependent protein deacetylase sir-2.1
- NAD-dependent protein deacetylase sir-2.4
- NAD-dependent protein deacylase sir-2.2
- NAD-dependent protein deacylase sir-2.3
- NAD-capped RNA hydrolase ndx-9
Sequence:
MVILRSKITRLYWFRLFSNGQKKIEYSKLKVAVPKEIFPGEKRVSLSPNGVALLKKNGISVLIEENAGVLAGYSNEEYVRSGADVGKHNEVFNTDIMLKVRPPTENEVSKLKSGCTLISFIHPGQNQALLDSLTKTDKTVFAMDCVPRISRAQVFDALSSMANIAGYRAVIEAANHFGRFFTGQITAAGKVPPAKVLVIGGGVAGLSAIGTSRGMGAVVRGFDTRAAVKEHVESLGAQFLTVNVKEDGEGGGGYAKEMSKEFIDAEMKLFADQCKDVDIIITTALIPGKKAPILITEEMIKSMKPGSVVVDLAAESGGNIATTRPGEVYVKHGVTHIGFTDLPSRLPTQSSELYSNNIAKFLLHLGKDKTFFVNEEDEVARGALVVRDGQMKWPPPPINFPPPAAPKSDKPSENTALVPLTPFRKTANQTLLLTSGLGSVSLLGIAGTNPQISSMSTTFALAGLVGYHTVWGVTPALHSPLMSVTNAISGTTAAGALCLMGGGLMPQNSAQTMALLATFISSVNIGGGFLVTKRMLDMFKRKDDPPEHNYLFSIPAAVFLGGYGYGVYTAAPLIHSYAYLGSSLCCVGALAGLSSQSTARVGNALGIIGVTGGIGATLGLLQPDFNTLCQMGGSVAMGSLIGLGIANRIKVTDLPQLVAAFHSFVGLAATLTCLANFIQEHPHFLEDPSNAAAAKLALFLGTYIGGVTFTGSLMAYGKLQGILASAPTYLPARHVLNGALLAGNVGALGTYMYSTDFGTGMSMLGGTVGLSSLMGVTLTMAIGGADMPIVITVLNSYSGWALCAEGFMLDNSLLTVLGALIGSSGAILSHIMCKAMNRSLLNVILGGVGTKSKGTGEAKAIEGTAKEIAPVETADMLLNARSVIIIPGYGLCAAQAQYPIAQLVKELQQRGVRVRFAIHPVAGRMPGQLNVLLAEAGVPYDIVEEMEEINEDFKETDVALVIGSNDTINSAAEDDPNSSIAGMPVLRVWNSKQVIIVKRTLGTGYAAVDNPVFFNENTQMLLGDAKKMSEKLLEEVKSKPM
Protein: Centromere protein X (CENP-X) (FANCM-associated histone fold protein 2) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Retinoic acid-inducible gene D9 protein homolog) (Stimulated by retinoic acid gene 13 protein homolog) (A8MT69)
Organism: Homo sapiens (Human)
Function: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own.
Subcellular location: Nucleus {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}. Chromosome, centromere {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS. {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}.
Interaction partners:
- Fanconi anemia core complex-associated protein 100
- Centromere protein W
- Fanconi anemia group G protein
- Fanconi anemia group A protein
- E3 ubiquitin-protein ligase FANCL
- Fanconi anemia group M protein
- Fanconi anemia group C protein
- Fanconi anemia core complex-associated protein 24
- Centromere protein S
- Fanconi anemia group F protein
Sequence:
MEGAGAGSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
Protein: Metastasis associated 1-like, isoform D (A0A0B4KG70)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone deacetylase HDAC1
- Chromatin assembly factor 1 p55 subunit
- Methyl-CpG binding domain protein-like, isoform C
- Chromodomain-helicase-DNA-binding protein Mi-2 homolog
- Simjang, isoform E
- MOG interacting and ectopic P-granules protein 1
- Chromodomain-helicase-DNA-binding protein 3
- CDK2-associated protein 1, isoform B
- Protein deacetylase HDAC6
- Possible lysine-specific histone demethylase 1
Sequence:
MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLATAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGTSNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTLLNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELESLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHKHEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIEYYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGSTDLSSNGKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAASTPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGIAISSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQAEIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPKPPKAPDGSLVYDRVPNKSPDVVAVPADKELTIIPTQATSTIRKRAHEDQQLNGTEVTIVPSGPPAKRPNKDPMPSHCPSPEQFAAMMAASGQPLSRHHLNGKQKIAQMARGGNGRKQVISWMDAPDDVYFRANDTHKKTRKILSAVDLRRAARKPWRTLPIKPAAPEPSSRPIESQIVILDXPSPASTLTASAASATKLLSSSASRFEQQHPPFPYTMDALLN