wanglab/gogpt-training-data huggingface dataset:
Protein: BCL2-associated X, apoptosis regulator a (Bax) (Bcl2-associated X protein, a) (Q9I9N4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- BCL2-like 11
- Apoptosis regulator Bcl-2
- Apoptosis regulator Bcl-2
- Cytochrome c
- Bcl-2-like protein 1
- Uncharacterized protein LOC767645
- Apoptosis regulator BAX-like
- BH3-interacting domain death agonist
- Caspase 8, apoptosis-related cysteine peptidase
- Beclin-1
Sequence:
MAAPSGGGDTGSGNDQILDLGAALLNNFVYERVRRHGDRDAEVTRSQLGGVELCDPSHKRLAQCLQQIGDELDGNAQLQSMLNNSNLQPTQDVFIRVAREIFSDGKFNWGRVVALFYFACRLVIKAISTRVPDIIRTIISWTMSYIQEHVINWIREQGGWDGIRSYFGTPTWQTVGVFLAGVITTALVIRKM
Protein: Basic leucine zipper 19 (AtbZIP19) (bZIP protein 19) (Q8VY76)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor involved in the response to zinc ion deficiency. Binds to the consensus sequence 5'-[AG]TGTCGACA[CT]-3' also called zinc deficiency response element (ZDRE). The ZDRE sequence is conserved in the plant kingdom and present in the promoters of genes that constitute the primary response to zinc deficiency, comprising additional ZIP metal transporter genes. Required for zinc accumulation in roots. Mediates the expression of the zinc transporters ZIP3, ZIP4, ZIP5 and ZIP9 during growth in zinc-deficient conditions. ZIP9 transporter is involved in zinc uptake in roots.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:26306426}.
Interaction partners:
- TPR repeat-containing protein ZIP4
- Zinc transporter 9
- Basic leucine zipper 8
- Nicotianamine synthase 2
- Nicotianamine synthase
- Probable nicotianamine synthase 4
- Nicotianamine synthase 3
- Nicotianamine synthase 1
- Fe
- Basic leucine zipper 34
Sequence:
MEDGELDFSNQEVFSSSEMGELPPSNCSMDSFFDGLLMDTNAACTHTHTCNPTGPENTHTHTCFHVHTKILPDESDEKVSTDDTAESCGKKGEKRPLGNREAVRKYREKKKAKAASLEDEVARLRAVNQQLVKRLQNQATLEAEVSRLKCLLVDLRGRIDGEIGSFPYQKPMAANIPSFSHMMNPCNVQCDDEVYCPQNVFGVNSQEGASINDQGLSGCDFDQLQCMANQNLNGNGNGSFSNVNTSVSNKRKGGHRASRAV
Protein: Hydroxycarboxylic acid receptor 3 (G-protein coupled receptor 109B) (G-protein coupled receptor HM74) (G-protein coupled receptor HM74B) (Niacin receptor 2) (Nicotinic acid receptor 2) (P49019)
Organism: Homo sapiens (Human)
Function: Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Hydroxycarboxylic acid receptor 2
- Density-regulated protein
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
Protein: Citrate exporter 1 (A0A254TZW7)
Organism: Aspergillus niger
Function: Transmembrane transporter that exports citrate across the cell membrane.
Subcellular location: Cell membrane {ECO:0000305|PubMed:31062025}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSSTTSSSRSDLEKVPVPQVTPRDSDSDKGSLSPEPSTLEAQSSEKPPHHIFTRSRKLQMVCIVSLAAIFSPLSSNIYFPALDDVSKSLNISMSLATLTITVYMIVQGLAPSFWGSMSDATGRRPVFIGTFIVYLVANIALAESKNYGELMAFRALQAAGSAATISIGAGVIGDITNSEERGSLVGIFGGVRMLGQGIGPVFGGIFTQYLGYRSIFWFLTIAGGVSLLSILVLLPETLRPIAGNGTVKLNGIHKPFIYTITGQTGVVEGAQPEAKKTKTSWKSVFAPLTFLVEKDVFITLFFGSIVYTVWSMVTSSTTDLFSEVYGLSSLDIGLTFLGNGFGCMSGSYLVGYLMDYNHRLTEREYCEKHGYPAGTRVNLKSHPDFPIEVARMRNTWWVIAIFIVTVALYGVSLRTHLAVPIILQYFIAFCSTGLFTINSALVIDLYPGASASATAVNNLMRCLLGAGGVAIVQPILDALKPDYTFLLLAGITLVMTPLLYVEDRWGPGWRHARERRLKAKANGN
Protein: Presporeless protein A (Q55FB8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Functions autonomously, very early in the prespore pathway, to control prespore cell differentiation, maybe at the level of transcription. Also required for proper aggregation.
Subcellular location: Nucleus {ECO:0000269|PubMed:9636072}.
Interaction partners:
- Serine protease/ABC transporter B family protein tagD
Sequence:
MGRMKVIPEFSNYKIRTPIPIFKNELEIEKYIKGAISYIYSENTAKKLELKKRNDEIKEILNNKNDHEFVEKKIRAIVIQLGDTNLNDRCYLNYLNLYKQPIEFTHGAIMCEKNKYWVAYYASQSLNLDCLNFIIKHKDQFKGLDKDKRIKPIDPKKKISRDLLIGQPITVQCIKEDDLFKFLTVYFNQNGIEFSDSWFSSIVKLIFKGKVYSSDESEKLSTTTTTTTTPNEKYDKKILGEHTVFINKNRDGHLKFSTIPSLLLKISTLMNTGVINEYKQKNYFLETLYNSFPANKHFFNFNEETIQYITNLLLPHLHPLEFKRFNTIPWIIKSKEFIDFIIQHKDFYHLVPSIHKFTKKHENTNLFSASTINDGEEEDDDDDDNDVDGNDDDNNKEKVDDTSNKKDSIVKFKDDITIYLNVRQRFLQFSNFELANYFHTKLLECQKESENQINSNIQSINKEIESLSTSSTNTASSTRSKASSNSNQLKKKEDLEQQIIELQSLLKNKYFSNKEIYYLSFLRALKDCDISTIESIDKVVSIDSDQNNNKFQILFQKSFLENQPLKNGISPEFYDFKKVGPSSHPDVYAEGEYDEHDEYDDYQGKLDNHIDIKDSKFTKDENSRDQLFNYLKSSGFKSFTPSIFCYLLELLLLINTEKSNQQFQEIFKPISTTTTTSTTTTTTTTNLDNINEKIFKLSSDLLIHLVHIVDFKKFSIILDSVNLNRKLILEMIDNCKNKLSFQKRIYEFHDVRSKDYQYDINGHFSTNIKFSDAKDILKKLIDENLFPTSKDWIFIYHSLYISILQSTGVTLNNLLEVNKIYEEHEINYPSVLPNHSNYILDFNNNNNNNNNNNYYGLLNYQPYNNSGNINNESLKNVVSNFVLFYWFHLLDRKLSKLFVRSFSNSNFNEFSSSRLPCLKNSSICRIRSKRHSNTASQIFKSIYELQNFSLLEKYSTFKSYFPEERSYYYNNPSDPFYHPDGSKDFRVLIEEGEFQLAFNHLQLVATKTVSEFPPLTTSRLFQFITLEDVIELINLTTIKNFDESKDESEQQPLLKMWYGKDVKKCKDWILSCAIAKSRLDIVDLLLVKDIEYSTLPSTIEFLTGYKIIKSLFSPECDNQTLEYFLTFSNGIVLPSIKQYLIKDNIATQTKNDVFRVIRHGIGKFELLRTFIPSLGFSSCLIEKMVENRRFETLQYYMEIGLITNEDLTNQQKDQLKYENDLKHLDWVINLNHKKRVNRNQPTFTPNTNSTTATTATPLLQTRSGRTIIPIKK
Protein: Salutaridine reductase (EC 1.1.1.248) (Q071N0)
Organism: Papaver somniferum (Opium poppy)
Function: Involved in biosynthesis of morphinan-type benzylisoquinoline alkaloids. Catalyzes specifically the stereospecific conversion of salutaridine to salutaridinol.
Interaction partners:
Sequence:
MPETCPNTVTKRRCAVVTGGNKGIGFEICKQLSSNGIMVVLTCRDVTKGHEAVEKLKNSNHENVVFHQLDVTDPIATMSSLADFIKTHFGKLDILVNNAGVAGFSVDADRFKAMISDIGEDSEELVKIYEKPEAQELMSETYELAEECLKINYNGVKSVTEVLIPLLQLSDSPRIVNVSSSTGSLKYVSNETALEILGDGDALTEERIDMVVNMLLKDFKENLIETNGWPSFGAAYTTSKACLNAYTRVLANKIPKFQVNCVCPGLVKTEMNYGIGNYTAEEGAEHVVRIALFPDDGPSGFFYDCSELSAF
Protein: BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) (Q6WVG3)
Organism: Mus musculus (Mouse)
Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
Subcellular location: Presynaptic cell membrane {ECO:0000269|PubMed:20400944}. Postsynaptic cell membrane {ECO:0000269|PubMed:20400944}. Note=Colocalizes with GABBR1.
Interaction partners:
Sequence:
MALADSARGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFFFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPPHSRRGVHKEGSLGDELLPLGYAEPEPQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE
Protein: Beta-defensin 12 (BD-12) (mBD-12) (Defensin, beta 12) (Q8K4N3)
Organism: Mus musculus (Mouse)
Function: Has antibacterial activity.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Beta-defensin 51
- Beta-defensin 15
Sequence:
MALSREVFYFGFALFFIVVELPSGSWAGLEYSQSFPGGEIAVCETCRLGRGKCRRTCIESEKIAGWCKLNFFCCRERI
Protein: Methyl-branched alkylpyrone synthesis polyketide synthase-like Pks11 (EC 2.3.1.-) (Chalcone synthase-like protein) (CHS-like) (Methyl-branched alkylpyrone synthesis polyketide synthase type III Pks11) (P9WPF3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the biosynthesis of methyl-branched alkylpyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA and methylmalonyl-CoA as extender molecules to synthesize polyketide products. Palmitoyl-CoA or a similar long chain fatty acid derivative is the likely substrate in vivo.
Interaction partners:
- Probable polyketide synthase Pks17
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Probable polyketide synthase Pks9
- Conserved hypothetical membrane protein
- Phenolphthiocerol/phthiocerol polyketide synthase subunit B
- Possible oxidoreductase
- Mycolipanoate synthase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit D
- Phenolphthiocerol/phthiocerol polyketide synthase subunit A
- Polyketide synthase-like Pks10
Sequence:
MSVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHLVLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKPTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEKRPPSGSAGLMLAMGPGFCTELVLLRWR
Protein: Large ribosomal subunit protein eL20w (60S ribosomal protein L18a-4) (Q8L7K0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g43860
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL42z/eL42y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein eL21x/eL21w
- Large ribosomal subunit protein eL21z/eL21y
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein eL32y
- Large ribosomal subunit protein eL24z
Sequence:
MSVIRLHQYQVVGRALPTEKDEQPKIYRMKLWATNEVLAKSKFWYYLRRQKKVKKSNGQMLAINEIFEKNPTTIKNFGIWLRYQSRTGYHNMYKEYRDTTLNGAVEQMYTEMASRHRVRFPCIQIIKTATVPASLCKRESTKQFHNSKIKFPLVFRKVRPPTRKLKTTFKANKPNLFM
Protein: Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75) (3X11A) (O73884)
Organism: Gallus gallus (Chicken)
Function: Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (By similarity). Involved in the generation of inorganic phosphate for bone mineralization.
Subcellular location: Extracellular vesicle {ECO:0000250|UniProtKB:Q8R2H9}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. {ECO:0000250|UniProtKB:Q8R2H9}.
Interaction partners:
- Uncharacterized protein.
- Phosphate cytidylyltransferase 1, choline, alpha.
- Ethanolamine kinase
- Glycerophosphocholine phosphodiesterase GPCPD1
- Ethanolamine-phosphate phospho-lyase
- Choline O-acetyltransferase
- Zinc finger protein 652
Sequence:
MKRCCEGVGLPCLFKGVGMASSRPPKYLLVFDFDGTIINESSDDSIVRAAPGQALPEHIRQSFREGFYNEYMQRVLAYMGDQGVKMGDFKAVYENIPLSPGMPDLFQFLSKNHELFEIILISDANMFGIECKLRAAGFYSLFRKIFSNPSSFDKRGYFTLGPYHSHKCLDCPANTCKRKILTEYLAERAQEEVEFERVFYVGDGANDFCPSVTLTSADVAFPRKGYPMHQMTQEMEKKQPGTFQATVVPWESATEVARYLQELLKKKC
Protein: Dormancy-associated protein 1 (AtDRM1) (Dormancy-associated protein-like 1) (AtDYL1) (B9DGG8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cold-regulated 413 plasma membrane protein 4
Sequence:
MVLLEKLWDDVVAGPQPDRGLGRLRKITTQPINIRDIGEGSSSKVVMHRSLTMPAAVSPGTPTTPTTPTTPRKDNVWRSVFNPGSNLATRAIGSNIFDKPTHPNSPSVYDCVDNEAQRKEHVALCLVGAWIK
Protein: Serine protease K12H4.7 (Q9VDX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RE65433p
- FI02848p
- Uncharacterized protein, isoform A
- trypsin
- RE36938p)
- trypsin
- Metalloendopeptidase
- Aminopeptidase
- Trypsin zeta
- Retinoid-inducible serine carboxypeptidase
Sequence:
MAALRLVCLFVVLAIGLVQSLDIPKIKDVPLLVKTLKNLNRGPPHQVVTKRANVQEKWITQKLDNFNASNTQTYQMRYLLNDEFQTEGSPIFIYLGGEWEIEESMVSAGHWYDMAQEHNGVLVYTEHRYYGQSIPTSTMSTEDLKYLDVKQALADVAVFIETFKAENPQLANSKVILAGGSYSATMVVWFKRLYPDLIVGGWASSAPILAKVDFTEYKEVVGQAFLQLGGQKCYDRIENGIAELESMFANKRGAEARAMLRLCNSFDDQNDLDLWTLFSSISNIFAGVAQYQGTGDIEYYCDYLLSFNDDATAIANFVYWAWGMGNCIDARYEGSVEYYLWGVDHFDASRPWYYQTCNEYGWYQSSGSRNQPFGTKFPATLYINLCGDVFSSQYGNEQINNNAASTNEYFGGMEPGVDNIYMTHGELDPWNPMGHGVEQGATVIANASHCSDFGSIKSTDSDEMRASKEKLAELVRQWLA
Protein: WD repeat-containing protein slr1409 (P73594)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Uncharacterized WD repeat-containing protein sll1491
- Slr0439 protein
- Uncharacterized WD repeat-containing protein slr1410
Sequence:
MRIFPVFLLTFSLFLIKEEIVTAEVKVSAPVVNQSGIKLNLERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLWTKEGEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWNLQGELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVLKSGTARNLAYHPQGLLIASVSDSGSLHLINPNGKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNLAGELIHEYKVVPTGWVNSAQFYPKGEWLATASDDGTIRFWQKDGQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFNLSY
Protein: GM09639p (Q95S42)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVIKPQDIPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVRDLNTYSDVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEESTNKPSNQESQHHRLAIDDMRTRLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRTQRINQTPIFGRKNPPVAIVGQKLQHAESLEDLASSGVAKQLATPAPKRSKATATTKGGRSSNPPLFLPPSLNISVALNSNGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPSAQQQRTSSNHRLPMCNNKGKTLKPLPSRTGSQGIPASNCVSPTRSSRPGSPTKHLAQRHTAATAQRLTNAAATHQQQHQQQSSKTTRLNILSPEKVHRLGARLTDQKQKMREEAAATASSVGGAGCAAGTAAGSLNGHRTIGSSGTPNSAVGERRRRAAPSPPVRTHFNTRC
Protein: Putative DEAD-box ATP-dependent RNA helicase 29 (EC 3.6.4.13) (O49289)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pescadillo homolog
- Ribosome production factor 2 homolog
- AT5g04600/T32M21_200
- Peter Pan-like protein
- Guanine nucleotide-binding protein-like NSN1
- Ribosome biogenesis protein BOP1 homolog
- DAR GTPase 3, chloroplastic
- Nucleolar-like protein
- DEAD-box ATP-dependent RNA helicase 13
- ATP-dependent RNA helicase DEAH13
Sequence:
MVEGKGFLVSSVTELHRKEKQKKKGKSGGFESLNLGPNVFNAIKKKGYKVPTPIQRKTMPLILSGVDVVAMARTGSGKTAAFLIPMLEKLKQHVPQGGVRALILSPTRDLAEQTLKFTKELGKFTDLRVSLLVGGDSMEDQFEELTKGPDVIIATPGRLMHLLSEVDDMTLRTVEYVVFDEADSLFGMGFAEQLHQILTQLSENRQTLLFSATLPSALAEFAKAGLREPQLVRLDVENKISPDLKLSFLTVRPEEKYSALLYLVREHISSDQQTLIFVSTKHHVEFVNSLFKLENIEPSVCYGDMDQDARKIHVSRFRARKTMLLIVTDIAARGIDIPLLDNVINWDFPPRPKIFVHRVGRAARAGRTGCAYSFVTPEDMPYMLDLHLFLSKPVRPAPTEDEVLKNMEEVMTKTSQAIDSGVTVYGRFPQKTIDLIFNRTREMIDSSAELDSLERTSTKAFRLYSKTKPSPSKESIRRAKDLPREGLHPIFRSIIETGELEAMSFFQKIKNFRPKQTILEAEGEVAKSKHVKGPAGQWVDVMKKKRAIHEEIINTRHQQNQKTSNNHLEMEAEPTTSFVDGTVEGSKVSGKKRKAQETFKDDEFFISSIPVNHHSEAGLSLRGNEGFGSNRLDAAVLDLVADDGQGIKQQQSNYHWDKKGKKYIKLNNGDRVTASGKIKTESGAKATAKKTGIYKRWQERSHKKVSRDSGDADETTRMSGRGGRDGKRRQGSVPNAHVRSEIKDLDQVRKERQQKANKVSYLQSKRGGRGGRGGARGGRGGGARGGRGGSRDFGGGGRDFGSSSDRGGRSGGRDFGGRRGGASTSSRGGKRGGGRGGGGKRGRGR
Protein: Hyphal wall protein 1 (Cell elongation protein 2) (P46593)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence factors and host inflammatory responses when protective immunity is absent.
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Hyphal surface. Localizes to the a/a Portion of the conjugation bridge during mating.
Interaction partners:
- Agglutinin-like protein 3
- Extent of cell elongation protein 1
- Hyphally regulated cell wall protein 1
- Transcriptional regulatory protein UME6
- Transcriptional regulator NRG1
- Agglutinin-like protein 1
- Hypha-specific G1 cyclin-related protein 1
- Secreted aspartic protease 5
- Enhanced filamentous growth protein 1
- Secreted aspartic protease 4
Sequence:
MRLSTAQLIAIAYYMLSIGATVPQVDGQGETEEALIQKRSYDYYQEPCDDYPQQQQQQEPCDYPQQQQQEEPCDYPQQQPQEPCDYPQQPQEPCDYPQQPQEPCDYPQQPQEPCDNPPQPDVPCDNPPQPDVPCDNPPQPDVPCDNPPQPDVPCDNPPQPDQPDDNPPIPNIPTDWIPNIPTDWIPDIPEKPTTPATTPNIPATTTTSESSSSSSSSSSSTTPKTSASTTPESSVPATTPNTSVPTTSSESTTPATSPESSVPVTSGSSILATTSESSSAPATTPNTSVPTTTTEAKSSSTPLTTTTEHDTTVVTVTSCSNSVCTESEVTTGVIVITSKDTIYTTYCPLTETTPVSTAPATETPTGTVSTSTEQSTTVITVTSCSESSCTESEVTTGVVVVTSEETVYTTFCPLTENTPGTDSTPEASIPPMETIPAGSEPSMPAGETSPAVPKSDVPATESAPVPEMTPAGSQPSIPAGETSPAVPKSDVSATESAPAPEMTPAGTETKPAAPKSSAPATEPSPVAPGTESAPAGPGASSSPKSSVLASETSPIAPGAETAPAGSSGAITIPESSAVVSTTEGAIPTTLESVPLMQPSANYSSVAPISTFEGAGNNMRLTFGAAIIGIAAFLI
Protein: Telomeric repeat binding factor 2 (J3KSZ6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XMIKTEFTLTEAVVESSRKLVKEAMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMT
Protein: Augurin (Esophageal cancer-related gene 4 protein homolog) (Q99LS0)
Organism: Mus musculus (Mouse)
Function: Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system. ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.
Subcellular location: Secreted {ECO:0000269|PubMed:17284679, ECO:0000269|PubMed:20404145}. Cytoplasm {ECO:0000250|UniProtKB:Q9H1Z8}. Apical cell membrane {ECO:0000250|UniProtKB:Q9H1Z8}.
Interaction partners:
Sequence:
MSTSSARPAVLALAGLALLLLLCLGPDGISGNKLKKMLQKREGPVPSKTNVAVAENTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVNYWLNRNRNGHDYYGDYYQRHYDEDAAIGPHSRESFRHGASVNYNDY
Protein: Neuronal vesicle trafficking-associated protein 1 (Brain neuron cytoplasmic protein 1/2) (Neuron-enriched endosomal protein of 21 kDa) (Neuron-specific protein family member 1) (P02683)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity).
Subcellular location: Membrane {ECO:0000269|PubMed:28874679}; Single-pass type II membrane protein {ECO:0000269|PubMed:28874679}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:28874679}. Endosome membrane {ECO:0000269|PubMed:18299352, ECO:0000269|PubMed:28874679}. Cell projection, dendrite {ECO:0000269|PubMed:12070131, ECO:0000269|PubMed:28874679}. Early endosome membrane {ECO:0000269|PubMed:12070131, ECO:0000269|PubMed:28874679}. Late endosome membrane {ECO:0000269|PubMed:28874679}. Lysosome lumen {ECO:0000269|PubMed:28874679}. Recycling endosome membrane {ECO:0000269|PubMed:12070131}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9461575}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9461575}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:9461575}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P42857}. Note=Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (PubMed:28874679). Endoplasmic reticulum targeting is essential for apoptosis (By similarity). Found in both stationary and motile endosomes. A previous study supports a type I membrane protein topology (By similarity). {ECO:0000250|UniProtKB:P42857, ECO:0000250|UniProtKB:Q62092, ECO:0000269|PubMed:28874679}.
Interaction partners:
- Syntaxin-12
Sequence:
MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPKIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKNTQCIPEGLESYYTEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA
Protein: Partner of numb (RE65495p) (Q9W4I7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein numb
- Bazooka, isoform B
- LD29223p
- Atypical protein kinase C
- LD33695p
- Inscuteable
- Maternal effect protein staufen
Sequence:
MLETKSIAALAFTETPRKRKRETLYKNAAPPPNPQQQPPEKDAQDAAVASTESCFTNAAFSSTPKKLMVARRRLAKENSQPNPFPGLEVKSIADLAQKQQHQQHHQQQQQQQQKLPTNPFEVLRQPPKKKKREHACFENPGLNLELPEKQFNPYEVVRSATTPAKGFVNPALNLRGSDAPASLNPFEIHRPSEASEAACNPSGVANPALADRDSEEQLPTSLKIGLPFTPTLGCRIDFHGMSLTQLTPSKLLAEKLVFSPVPAPKRSLGAISEESSMDIGKELDRYQLELENSINEAKLRKNGVLVDRELPRNSLEVELPKNTKVSLVMETNTQELMMQEVVTVDTQVERRLVCTRRRTLTEISEASEVEEDTEKLLEQDREAEVILEQEKILEQEMVSERERHLTREKQLKQEKLLEREKHLEREKLQEKLHEQLREKLQERAKHLEKEKLEEEELLERQLEEEREKEPTDGDVAYASESESDDEPDDLDFKAPARFVRAYRPAALPSKAASKESLQSIGSSKSAKSAEVKPSIGMKGMIRKSIRRLMHPTSHTTPSEVKSEDKDEHGHGQGHGQHNILNSIRHSLRRRPQKAAELEEQMEPVLADVSIIDTSERTMKLRSSVAQTEYMTIEQLTNEKKHSLRNSIRRSTRDVLRHVFHKSHDAYATAK
Protein: SAP domain-containing protein (Q57YZ6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Large ribosomal subunit protein uL3m
- Uncharacterized protein
- Ribosomal protein L9 domain-containing protein
- tRNA/rRNA methyltransferase SpoU type domain-containing protein
- Uncharacterized protein
- Ribosomal protein L9 domain-containing protein
- Uncharacterized protein
- Large ribosomal subunit protein mL43
- Uncharacterized protein
- Large ribosomal subunit protein uL23m
Sequence:
MQDKAVQKALMEKRARLLLGVRMNYAPFSFMRRRRITAAALPVAERSDPLSICYRCVHERPFVEPPPEGDNNSDGEAYETARDALLQLNMMVRRGIEPDALMYTSLIATMGRARLEWQAYKLFSRMLESGIRPLPETYVALHDATSPRRHHLRCDLQQKIEESLETFPEELAEAELQLQRERDRLCVQKFEEYMSGVLPPAPPPPPSEQEAISVRDKEREGDRSSSFGGGSNAAGLGKSDAKPIATMHIRNPTDAWSTARMMDEQQKLGNQRAQGSTAISLCEQLDKLHEEELRIFLSAQRQLRHGNKTDLVKRVLHCVSEKSIRDMLERRKHYFQSVAHILENDLNSLRRDGIMAENKADESVNNEGTDAIPSAANSGGSQPVIISYACGVDQTITAEEKESVAPDFLHTPWGILRKPVRHTSTGEKSRSIDRLQRLSLNVDELQLVRSKASTGDLDELPESLLRRYAYQFSLTWKRRHPLSLLEAVQWHSTTLLPQQLNEEGGASPTPALRRQQEDEGVHKTLENYEAFRIISQRTNNLQVVDNKEINLHLKAIRREALRKERRAEETLRREHSLLEAAALAASAKSFTPPEEDMVPSSRVLGVDAEHNNDNESSGRLLPTSSDWEKGESQEDEPKELPPWAIFNGEEEFNMTTGRFGDPRIGRYQELSDGRFKILPSREAQSRWTVNRQLLPGALQDTLQRAELQQKTRVEAVEKVHQEKLKFKRYRKWDAFLRKAQDKQKGKPQTDDKEGDGDGKKSAGPLPAKKRLSLLLRKGKDKAPIDDAVKAKYCKTL
Protein: Calcium dependent secretion activator 2 (H0Y8B5)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
XYTRLTEYAKIEGPAEKETETMNQASPARKLEEILHLAELCIEVLQQNEEHHAEGREAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQPVKNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYESTNGSATSEDLFWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG
Protein: Missing-in-metastasis, isoform D (E1JGY9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDLSLERDSSALGSLFQQIINDMKNTSPLWEDFVAKAGKLHTCLRAAIQAIAAYLDAFQKIADAATNSRGASKEIGTALTRVCLRHKAVETRLKTFTSTIMDCLVQPLQERIEDWKRTVATIDKDHAKEYKRCRSELKKRSSDTLRLQKKARKGQTDGLQSLMDSHMQDVTLRRAELEEVEKKSLRAAMVEERLRYCSFVHMLQPVVHEECEVMSELGHLQEAMQSIALVTKEPSVLPQASEELIHDAKASINLYPESPGGGSGSQGGGCSNSLGSRKSSVCSISSMNSSGSSNSPGHHHYPRSLSQTSNATNQTANVSTWPPHSQDGVDTLPPTADRPHTISTAYEKGHQRPPLTVYTFQNPETIHESGSCLNNGTAAPNGQPLSGQATPATQKSPAASLSRPPLPVRCSSLERPLSAQSNHRQGSGNNLLQRQCPSPIPAHITKELSAAHHAQQQQQQQNQQPQTPPTYVNMSELATMAALKQTNQQQKPSTPPLQQQSSIDSTSSQHSNDSTGSHQLLQQQQQHHQSQQNHHSATATRSHSISSTASSLHSHPSIDSTVACGSLVGQHNHSTSTNTNTTSPSSGSSTPQNHYSPLLTNSPTSTAAGTPSGSSLGPGSGLGFVYQVSSPTPPSSEVLKITEQAAAGQDQGPANSVADETDERSRASVLQKASMFEKAAAAAAVSPPAPMQIASGSPASGGGTRRSEAEQQEMGGAAGGGSTRIGRRSSINQSKPPPPVRRSSSVTPSPNASVGTFRTSSPAAGGGGGGGIYAQPKLVNSMSSFRTSSPSPNGHAHPLPPTQPKANPNLIAQLNARLSGKQQQHQQQQHIEGIYGNQQAPGGESIYMRSGLSMSQPQQQQHFDDYATSTNIEKTGSIRAKTKAEFLENLNAKLAKQGMSGRAFAVRNLINSKALPDPRICHESLMDQIKRGATLKRNQKINDRSAPKIH