wanglab/gogpt-training-data huggingface dataset:
Protein: Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) (Q60610)
Organism: Mus musculus (Mouse)
Function: Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration.
Subcellular location: Cell junction {ECO:0000269|PubMed:17339315}. Cell membrane {ECO:0000269|PubMed:17339315}; Peripheral membrane protein {ECO:0000269|PubMed:17339315}; Cytoplasmic side {ECO:0000269|PubMed:17339315}. Note=Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (By similarity). Detected at the boundary between cells with actin-rich protrusions. {ECO:0000250}.
Interaction partners:
- Ras-related C3 botulinum toxin substrate 3
- Cell division control protein 42 homolog
- CD44 antigen
- GTPase HRas
- GTPase KRas
- Partitioning defective 3 homolog
- Ras-related C3 botulinum toxin substrate 1
- Ras-related C3 botulinum toxin substrate 2
- Ankyrin-3
- Ankyrin-2
Sequence:
MGNAESQNVDHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKAIHRNSEVSTRSSSTPSIPQSLAENGLEPFSQEGALDDFGDPIWVDRVDMGLRPVSYTDSSVTPSVDGSIVLTAASVQSMPDSEESRLYGDDATYLAEGGRRQCPYTSNGPTFMETASFKKKRSKSADIWREDSLEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETEASPRQLSTCQRANSLGDLYAQKNSGVKANGGPRNRFSSYCRNLVSDIPDLAKHKMPPAAAEETPPYSNYNTLPCRKSHCLSEGATNPQISLSKSMQGRRAKTTQDVNTGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPPTGRAFVGSDSGSSSTGDRARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYETDGRSGIDHNSVPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACAAAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVSSFHALVAARTGEIGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPTINQVFGEGTDAVKRSLEGIFDDTVPDGKREKEVVLPSVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKTHQLDHSAHYLRLKFLMENRVQFYIPQPEEDIYELLYKEIEICPKVTQNIHIEKSDAAADNYGFLLSSVDEDGIRRLYVNSVKETGLASKKGLKAGDEILEINNRAAGTLNSSMLKDFLSQPSLGLLVRTYPEPEGGVELLENPPHRVDGPVDLGESPLAFLTSNPGHSLSSEQGSSAETAPEEGEGPDLESSDETDHSSKSTEQVAAFCRSLHEMSPSDSSPSPQDATSPQLATTRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPRQQHSSTLESYLIKPIQRVLKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTSVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYEEWDPFRFRHMIPTEALQVRALPSADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKSVHSILRDKHRRQLLKTESLPSAQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLARNRFTIDSDAISASSPEKEPQQPAGGGDTDRWVEEQFDLAQYEEQDDIKETDILSDDDEFCESLKGASVDRDLQEQLQAASISQRARGRRTLDSHASRMTQLKKQAALSGINGGLESASEEVIWVRREDFAPSRKLNTEI
Protein: Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18) (P04853)
Organism: Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))
Function: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.
Subcellular location: Virion membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Host cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Folded in the endoplasmic reticulum. {ECO:0000250}.
Interaction partners:
Sequence:
MDGDRGKRDSYWSTSPSGSTTKPASGWERSSKADTWLLILSFTQWALSIATVIICIIISARQGYSMKEYSMTVEALNMSSREVKESLTSLIRQEVIARAVNIQSSVQTGIPVLLNKNSRDVIQMIDKSCSRQELTQHCESTIAVHHADGIAPLEPHSFWRCPVGEPYLSSDPEISLLPGPSLLSGSTTISGCVRLPSLSIGEAIYAYSSNLITQGCADIGKSYQVLQLGYISLNSDMFPDLNPVVSHTYDINDNRKSCSVVATGTRGYQLCSMPTVDERTDYSSDGIEDLVLDVLDLKGRTKSHRYRNSEVDLDHPFSALYPSVGNGIATEGSLIFLGYGGLTTPLQGDTKCRTQGCQQVSQDTCNEALKITWLGGKQVVSVIIQVNDYLSERPKIRVTTIPITQNYLGAEGRLLKLGDRVYIYTRSSGWHSQLQIGVLDVSHPLTINWTPHEALSRPGNKECNWYNKCPKECISGVYTDAYPLSPDAANVATVTLYANTSRVNPTIMYSNTTNIINMLRIKDVQLEAAYTTTSCITHFGKGYCFHIIEINQKSLNTLQPMLFKTSIPKLCKAES
Protein: Protein arginine N-methyltransferase 2 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT2) (P55345)
Organism: Homo sapiens (Human)
Function: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Subcellular location: [Isoform 1]: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.; SUBCELLULAR LOCATION: [Isoform PRMT2Alpha]: Nucleus. Note=Excluded from nucleolus.; SUBCELLULAR LOCATION: [Isoform PRMT2Beta]: Cytoplasm. Nucleus. Nucleus, nucleolus.; SUBCELLULAR LOCATION: [Isoform PRMT2Gamma]: Nucleus. Note=Excluded from nucleolus.; SUBCELLULAR LOCATION: [Isoform PRMT2L2]: Cytoplasm {ECO:0000269|PubMed:21820040}. Nucleus {ECO:0000269|PubMed:21820040}. Note=Predominantly cytoplasmic.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein A1
- Heterogeneous nuclear ribonucleoprotein U-like protein 1
Sequence:
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVIWPTMAALHLVPCSADKDYRSKVLFWDNAYEFNLSALKSLAVKEFFSKPKYNHILKPEDCLSEPCTILQLDMRTVQISDLETLRGELRFDIRKAGTLHGFTAWFSVHFQSLQEGQPPQVLSTGPFHPTTHWKQTLFMMDDPVPVHTGDVVTGSVVLQRNPVWRRHMSVALSWAVTSRQDPTSQKVGEKVFPIWR
Protein: Siderophore iron transporter 1 (O74395)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the transport of siderophore iron and so has a role in iron homeostasis.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Ferric reductase transmembrane component 1
- Iron transport multicopper oxidase fio1
- Plasma membrane iron permease
Sequence:
MRLKSFSTTLDTLRRRFNDSSSEEDKLEKNIQDETSIKEVSLQDAKQSDEKGVEEKVFNDESFSIDVAPKPEDELSGIVKARYLTEHSSRISFYICYFSIFLLFFAISFQAECYYSLTAYATSAFAGHSLLSTIAVANNIISAAIKPPLARLSDVFGRLEAFLFSLLLYLVGLILMAASTNVQTYAGGSVLYNAGYTGVELIMTIFMADTSSMANRSLVLGISYLPFVVTIWIGPRVAQEFYMHSTWRWGIAVWTILIPACSIPFLAVYSYYQFRAWREGALKGTLTINPVELFKKLDIIGLILMTAGLALVLLSISLASYDTGKWSDAKFIVMIIIGGLCLIAFVLYEIFVASFPALPFRLMREPTIGACCAMSFLFYITFYCWDNYYYSFLQVVHYTSITAAGYISYTYSFTSCATGFFLGILIRLTKRYKWYFVASIPVYILGQGLMIRYRGEQYNWGYQIMPQIIVGIGGGVIANLLTVAVQTVVSTENFAIVTALVSTVTPIGGAVGSAISGAIWNSVMPKRLEKNLPSDLKDQAYTIFESLTVQLSYTRGTDARNAIILSYSEVQKILTSVATGFAGAMIFPVWFVANPRLSTVKTHIFDSKESKV
Protein: Major DNA binding protein (Q77CC7)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Interaction partners:
Sequence:
MDAAAKTVALAPGPAGFVYVCDAARLDLDKLALLAARSRDSLLAVLPLVRGLTVETAFAPNVAVVAGTKTTGLGGAGLTAKLTPSHYHPNVFVFHGGERLRASTAAPNLTRACEQARRRFGFSAFAGAPVDGAVETTAEDICRAVGASPETALVFLATTEAFKETVYMCNTFLHYGGAAPVQVGAGEAVRVPLYPVQLYMPDVNRVNLEPFNARQRAIGEQLAYPRPFYNAALCELLHGYVLGPAAVALRVRTLDAVARGAAHLAFDESHEGAVLPPDVCFTVFDQPAGRGGGRGSARGADPGAAKAAAPGGVERRLASVMAADTAVSIEAAMSTSVFDEDVACVDDWPMLQGAADDAAKLDALGAYVGRLAGLVGAMVFSSNSVLHMTEVDDGGAADAKDGAAAGFHRFYQIAAPYAAGNPRCDKDGKPLPQTGAGPAVSINGAGQEFALDHLALACGFCPQLLARMLFYLERCDAGAFAGRNDMDALKYVASTLEGDVPCGLCSRDDRHACAHTTLHRLRHRLPRFGAPTRSPLGVFGTMNSAYSDCDVLGNYASYSALRRPGADENARSIMQATYRAAVENVLAELDQQRLLAHDAQSAAQLERAITDHASFRGALAAIQNTVEQATEAFVRGLVEDRDFKMREALYEANHTLSLALDPYSTAVCPATAFLFRRSVLAVVQDLALSQCHGIFCGQPVDGRNFRAQFQPVLRRRFMDLLNGGFLTTRTVTVTLAEAAVAAPNLAAAQTEPPARDMDGDISKVSLEVFKEMRVKNRVMFSAGNANMSEAARARVLGLAGAYQKPESGGVNILSGPLGFLVKQFHRKLFPNGKPPGSPTPNPQWFWTLLQRNQMPARLLSKEDIETIGAVKRFSDAYAAINYVNLTPGNVAELAQFYMANLVLRHCDHKQFYINGLTAIVAGARRPRDPAAVMHWVRRRIADAPDAAAAAEEVLREAEARPEVWAGTFAASNLVRSVMATRPAVVLGLSISKYNGSAGNNRVFQAGNWSGLNGGKNVCPLLCFDKTRRFVLACPRAGFVCATAGAGGANRDNTLVEALREIINGSNGALAQTAVYGAVLQALGPRVEHMDLDDWAALVEDEFFAQSMVELTERAAARPGGWSPEGAADMLRELELEAAAEAEPAGGAFDFGACASAAPDATYAFGGPVAGAGPAAPGAKRPDLDELFEMGVPDKRPALTIDMV
Protein: Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2) (P07307)
Organism: Homo sapiens (Human)
Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- Asialoglycoprotein receptor 1
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
- Thyroglobulin
- Ceramide synthase 2
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
- Sodium/potassium-transporting ATPase subunit beta-2
- V-type proton ATPase 16 kDa proteolipid subunit c
- von Willebrand factor
Sequence:
MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFSLLALSFNILLLVVICVTGSQSEGHGGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRFVACQMELLHSNGSQRTCCPVNWVEHQGSCYWFSHSGKAWAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDSDGSWKWVDGTDYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVCEKRRNATGEVA
Protein: Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDKAL1-like protein) (tRNA-t(6)A37 methylthiotransferase) (Q7K4W1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein sprouty
- Protein tamozhennic
Sequence:
MYHLGQDLPGNDVDDIEDLISADDVKPRERYENKKTVTVRAKKRSQIRLESQEEEEKPKPTIHESVIPGTQKVFVKTWGCAHNNSDSEYMAGQLAAYGYRLSGKEEADLWLLNSCTVKNPSEDTFRNEIESGMRNGKHVVVAGCVPQGAPKSDYLNGLSVIGVQQIDRVVEVVEETLKGHSVQLLQNKKKVHGRRVAGAPLSLPKVRKNPLIEIISINSGCLNQCTYCKTKHARGDLASYPPEEVVERARQSFAEGCCEIWLTSEDTGAYGRDIGSSLPELLWQLVEVIPEHCMLRVGMTNPPYILEHLEEVANVLQHPRVYSFLHVPVQSGSDSVLGEMKREYCRQDFEHVVDFLRERVPGVTIATDIICGFPTETEDDFEETMTLCAKYRFPSLFINQFFPRPGTPAAKMDRIPANLVKKRTKRLTDLFYSYEPYADRVGEIYTVLVTEVSHDKLHYVGHNKSYEQVLLPMRDNLLGTRVHVRITSASKFSMVGEILDDERDWTRCAKNQELPNVQVQTRSRERLIQRYFGIALVLGSLAFLIQLVVRLL
Protein: Max dimerization protein 3 (Max dimerizer 3) (Max-associated protein 3) (Q80US8)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:8521822}.
Interaction partners:
- Protein max
Sequence:
MEPVASNIQVLLQAAEFLERREREAEHGYASLCPHHSPGTVCRRRKPPLQAPGALNSGRSVHNELEKRRRAQLKRCLEQLRQQMPLGVDCTRYTTLSLLRRARVHIQKLEEQEQQARRLKEKLRSKQQSLQQQLEQLQGLPGARERERLRADSLDSSGLSSERSDSDQEDLEVDVESLVFGTETELLQSFSAGREHSYSHSTCAWL
Protein: Protein 4.1 homolog (Protein coracle) (Q9V8R9)
Organism: Drosophila melanogaster (Fruit fly)
Function: An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development.
Subcellular location: Cell junction, septate junction. Note=Septate junction in the apical-lateral domain of epithelial cells during embryonic and imaginal disk development.
Interaction partners:
- Neurexin-4
- Probable sodium/potassium/calcium exchanger CG1090
- Peripheral plasma membrane protein CASK
Sequence:
MPAEIKPSAPAEPETPTKSKPKSSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYRYKGRTQAESTNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRGDRNADGDAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKAAKAALAAGAAAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRLGLVVTSGLGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYTPGGFRYDQDPNSRKSGADGQEQLSPTSQQKKIGLAFNYAPGNENALKETAEKLKAGQLSPRTQDKLNRGQLSPKSRAKLLQDPLLSPTTRAKLQGSAVDAAAVPLSDSQKRSYSPTKGPQGYSSGAPGSYKPISDPTADFLESQRYNKEPGYVGPSKADVAAGLAGAAGSKKPGSPTKTGKGAPGAAAAAAAGAAGAAAAAAKPKKRRVKIMVITSKFDPSTKRIDAENGSIEHSTGILDPATGLIDTKYGVIDPKKGTLEALNTKTGKKEVFQGDVDGKTGNLHLVSGVADPKTGRLDDTLGQIVCITPQDNPVVELTVITSRIDPATGKIDTVNGDVERSLGVLNLDTGLLDTKYGEINTRTGELKAIDPKSGKIVVSKNVKVDPGTGQITILGIVDPKTNKIDPNQGRLIEVGQQIDPIVEVTSLAGKFDSKRNIIDPKTAQVETSGGQFDPKAGKIDTKYGQIDLVKHTITFNDPKSGKTVTRDIKIEPTTGQIVLKNQVNPKNNKPDKDYARIISLRIVQQRVDPATKAPITEVSASKDKDIVVDPKSNQIWVPTGATDPATKEQQYISSSVDPKTGYVITIYGYLDPKTNEIKKQTKLDPNTIKIEPTSGKIYTATGEVDQATGEPLYAATQVDPESGEVYTKLARVDPKTGKIVIVRILLISKTDERGRPEEIDPSTCEIDPVSGRVLKFFNKTVYVYNMIDPVTGEIVQVDPNDPRFAGARTTVTHTMTLTGEIDPVTGRIKSEYGDIDPNTGDIDPATAVTDPVTGKLILNYAQIDPSHFGKQAQVQTTTETVPITRQQFFDGVKHISKGALRRDSEGSSDDDMTAQYGADQVNEILIGSPAGQAGGKLGKPVSTPTVVKTTTKQVLTKNIDGVTHNVEEEVRNLGTGEVTYSTQEHKADATPTDLSGAYVTATAVTTRTATTHEDLGKNAKTEQLEEKTVATTRTHDPNKQQQRVVTQEVKTTATVTSGDQYQRRDSVSSTSSGDSGTPIDGPYDGASVVRTDNQKSPLFTTSATTGPHVESTRVVLGEDTPGFSGHGEIISTQTVSSKTRTVETITYKTERDGIVETRVEQKITIQSDGDPIDHDKALAEAIQEATAMNPDMTVEKIEIQQQTQ
Protein: Endoglucanase 24 (EC 3.2.1.4) (Endo-1,4-beta glucanase 24) (Q93YQ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- GDSL esterase/lipase At3g43550
- Cysteine/Histidine-rich C1 domain family protein
- RING/U-box superfamily protein
- RBR-type E3 ubiquitin transferase
- Cellulase
- Protein IQ-domain 26
- Protein trichome birefringence-like 43
- Endo-polygalacturonase-like protein
- Serine carboxypeptidase-like 31
- Glucan endo-1,3-beta-glucosidase 7
Sequence:
MKLHLHPLSLVFFFFFFFFRPTMSSNQHDYSDALSKSILFFEGQRSGYLPNDQRMTWRRNSGLSDGWTHNIDLTGGYYDAGDNVKFNFPMAFTTTMLAWSVIEFGEFMPSSELRNSLVALRWSSNYLLKSVSQLPNRIFVQVGDPIADHNCWERPEDMDTPRTAYAVNAPNPASEVAGETTAALSAASIAFRSSDPGYSQTLLQNAVKTFQFADMYRGAYSSNDDIKNDVCPFYCDFNGFQDELLWGAAWLRKATGDESYLNYIESNREPFGANDNVDEFGWDNKVGGLNVLVSKEVIEGNMYNLEAYKASAESFMCSLVPESSGPHVEYTSAGLLYKPGGSQLQHATTISFLLLVYAQYLSRSSLSLNCGTLTVPPDYLRRLAKKQVDYILGNNPMGLSYMVGYGERYPKRIHHRGSSLPSIVDHPEAIRCKDGSVYFNSTEPNPNVLIGAVVGGPGEDDMYDDDRSDFRKSEPTTYINAPFVGVLAYFAANPGSS
Protein: Transforming growth factor beta regulator 1 (Nuclear interactor of ARF and Mdm2) (Q3YBR2)
Organism: Homo sapiens (Human)
Function: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
Subcellular location: Nucleus {ECO:0000269|PubMed:17110379}.
Interaction partners:
- Rab-like protein 6
Sequence:
MSLLDGLASSPRAPLQSSKARMKKLPKKSQNEKYRLKYLRLRKAAKATVFENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGEVQAAAPSHSSSLPLTYGVASSVGTIQGAGPISGPSTGAEEPFGKKTKKEKKEKGKENNKLEVLKKTCKKKKMAGGARKLVQPIALDPSGRPVFPIGLGGLTVYSLGEIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQIKDGGVQPQFEIVPEDDPQNAIVSSSADACHAELLRTISTTMGKLMPNLLPAGADFFGFSHPAIHNLIQSCPGARKCINYQWVKFDVCKPGDGQLPEGLPENDAAMSFEAFQRQIFDEDQNDPLLPGSLDLPELQPAAFVSSYQPMYLTHEPLVDTHLQHLKSPSQGSPIQSSD
Protein: MADS-box transcription factor family protein (B3H5S0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Putative clathrin assembly protein At1g33340
- Ribosome biogenesis protein NOP53
- Putative clathrin assembly protein At5g65370
- Putative clathrin assembly protein At1g14686
- Putative clathrin assembly protein At5g35200
- Putative clathrin assembly protein At5g10410
- Putative clathrin assembly protein At4g25940
- Putative clathrin assembly protein At1g14910
- Reverse transcriptase
- Putative clathrin assembly protein At5g57200
Sequence:
MYSSMSTKKKTKLSVRNQTCFKKSSLSSSSTAKKTTNLSMREQTMFKKALELSTLCDIEVCVILYGRDGELIKTWPEDQSKVRDMAERFSRLHERERCKKRTNLSLFLRKKILDDNKLSEKVLEMEDSLESGLRVLQNKLLLLQPEKNQTKLGQSRAVSSTTNLLSSPENHHNQQWTEPLENGVSNTEQELSTSSLSQHQSKYSVFLYNHDNGSFYQVPDSICF
Protein: Serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) (P9WFT7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00176}.
Interaction partners:
- Lysine--tRNA ligase 1
- Leucine--tRNA ligase
- Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX
- Arginine--tRNA ligase
- Threonine--tRNA ligase
- Cysteine--tRNA ligase
- Tyrosine--tRNA ligase
- Valine--tRNA ligase
- Isoleucine--tRNA ligase
- Peptide chain release factor 2
Sequence:
MIDLKLLRENPDAVRRSQLSRGEDPALVDALLTADAARRAVISTADSLRAEQKAASKSVGGASPEERPPLLRRAKELAEQVKAAEADEVEAEAAFTAAHLAISNVIVDGVPAGGEDDYAVLDVVGEPSYLENPKDHLELGESLGLIDMQRGAKVSGSRFYFLTGRGALLQLGLLQLALKLAVDNGFVPTIPPVLVRPEVMVGTGFLGAHAEEVYRVEGDGLYLVGTSEVPLAGYHSGEILDLSRGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCTPADAEHEHERLLGWQRQMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWIPTQGAYRELTSTSNCTTFQARRLATRYRDASGKPQIAATLNGTLATTRWLVAILENHQRPDGSVRVPDALVPFVGVEVLEPVA
Protein: Hexaprenyl pyrophosphate synthase (HexPP) (EC 2.5.1.82) (Medium-chain HexPP) (Q97W92)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Catalyzes consecutive E-type condensation of two isopentenyl pyrophosphate (IPP) molecules with an allylic substrate such as geranylgeranyl diphosphate (GGPP), farnesyl diphosphate (FPP) or geranyl diphosphate (GPP) to yield the medium-chain product trans-C30-hexaprenyl pyrophosphate (HexPP). GGPP is the physiological substrate.
Interaction partners:
- Tritrans,polycis-undecaprenyl-diphosphate synthase
- Phytoene synthetase
- Geranylgeranyl diphosphate synthase
- 4-hydroxybenzoate octaprenyltransferase
- Uncharacterized protein
- S-methyl-5'-thioadenosine phosphorylase
Sequence:
MSIIEFWLEAKATIDRLIEQFLNSNRDWDLVDISSYILKDGKRFRGTLNMFFTVALGGDIKDSYGGALAIEILHSASLALDDIVDLDATRRGDKAAWVVYGNRKVIFITNYLIPTALRIIQTSYGDDALNTSIELWKDTSVGALRDMYDNSDYIRTIELKTGSLFKLSTVLSAYASKHYNTKQQMLDVGKYLGIIYQVIDDFVDYKTKKVEEIDGSAKQLFKYYREGKLEEYVRSVYLEYKQKYDELISNIPFQSKYLSEIRSLPEFLANGLLKEANIDKI
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit) (Q561S0)
Organism: Rattus norvegicus (Rat)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:O95299}.
Interaction partners:
- NADH dehydrogenase 1 subunit C2
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
Sequence:
MALRLLRLVPASASARGLAAGAQRVGRIHTSVHCKLRYGLLASILGDKTTKKLHEYSRVITVDGNICSGKNKLARDIAEQLGMKHYPEAGIQYSSSTTGDGRPLDIEFSGSCSLEKFYDNPKSNDGNSYRLQSWLYASRLLQYSDALEHLLSTGQGVVLERSIYSDFVFLEAMYNQGFIRKQCVDHYNEIKRLTLPEYLPPHAVIYIDVPVSEIQSRIQKKGDPHEMKVTSAYLQDIEDAYKKTFLPKMSEICEVLVYSSWEAEDSTKVVEDIEYLNYNKGPWLKQDDRTFHNLRMLVQDKREVLNYTTVPVYLPEITIGAHQGSRIYDSFRELPGRKYAPGYNADVGDKWIWLK
Protein: Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) (Q9Y2Z0)
Organism: Homo sapiens (Human)
Function: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21864708}. Nucleus {ECO:0000269|PubMed:21864708}. Note=Translocates to the nucleus upon heat shock, requiring S100A6.
Interaction partners:
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- S-phase kinase-associated protein 1
- Nucleotide-binding oligomerization domain-containing protein 1
- NACHT, LRR and PYD domains-containing protein 3
- PH domain leucine-rich repeat-containing protein phosphatase 1
- Endoplasmin
- DnaJ homolog subfamily C member 7
- Cysteine and histidine-rich domain-containing protein 1
- S-phase kinase-associated protein 1
Sequence:
MAAAAAGTATSQRFFQSFSDALIDEDPQAALEELTKALEQKPDDAQYYCQRAYCHILLGNYCVAVADAKKSLELNPNNSTAMLRKGICEYHEKNYAAALETFTEGQKLDIETGFHRVGQAGLQLLTSSDPPALDSQSAGITGADANFSVWIKRCQEAQNGSESEVWTHQSKIKYDWYQTESQVVITLMIKNVQKNDVNVEFSEKELSALVKLPSGEDYNLKLELLHPIIPEQSTFKVLSTKIEIKLKKPEAVRWEKLEGQGDVPTPKQFVADVKNLYPSSSPYTRNWDKLVGEIKEEEKNEKLEGDAALNRLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKKY
Protein: Papillary renal cell carcinoma isoform 3 (A0A0S2Z470)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLVAYASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPAPKGPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGFPPPPGVSPAEAAGVGEGLGLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDSDSEEDEPTKKKTILQGSSEGTGLSALLPQPKNLTVKETNRLLLPHAFSRKPSDGSPDTKPSRLASKTKTSSLAPVVGTTTTTPSPSAIKAAAKSAALQVTKQITQEEDDSDEEVAPENFFSLPEKAEPPGVEPYPYPIPTVPEELPPGTEPEPAFQDDAANAPLEFKMAAGSSGAPWMPKPGDDYSYNQFSTYGDANAAGAYYQFKRLQGKRNRGREEINFVEIKGDDQLSGAQQWMTKSLTEEKTMKSFSKKKGEQPTGQQRRKHQITYLIHQAKERELELKNTWSENKLSRRQTQAKYGF
Protein: F-box only protein 11 (Q7TSL3)
Organism: Rattus norvegicus (Rat)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53LOG.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q86XK2}. Chromosome {ECO:0000250|UniProtKB:Q86XK2}.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
- MDS1 and EVI1 complex locus
- E3 ubiquitin-protein ligase RBX1
Sequence:
MVAEESGPGAQNSPYQLRRKTLLPKRTACPTKNSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN