wanglab/gogpt-training-data huggingface dataset:
Protein: Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (Q86XP1)
Organism: Homo sapiens (Human)
Function: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016}. Cell membrane {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016}. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli (PubMed:12810723). Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association (PubMed:12810723). Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS (PubMed:19710016).
Interaction partners:
- Lipoprotein lipase
- Dihydroxyacetone phosphate acyltransferase
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
- Membrane-bound glycerophospholipid O-acyltransferase 1
- Membrane-bound glycerophospholipid O-acyltransferase 2
- Phosphatidate cytidylyltransferase 2
- 1-acyl-sn-glycerol-3-phosphate acyltransferase delta
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
- Lysocardiolipin acyltransferase 1
Sequence:
MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQIRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEASEEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVADAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLGDDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTETDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQELAHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEERVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQKQKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGHVKRILQGIKELGRSTPQSEV
Protein: Fibroblast growth factor (FGF) (Q38PL0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Fibroblast growth factor receptor 1-A
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 3
- Fibroblast growth factor receptor.
- Fibroblast growth factor receptor 4
- receptor protein-tyrosine kinase
- Homeobox protein MSH-B
- Platelet-derived growth factor receptor, beta polypeptide
- receptor protein-tyrosine kinase
- Platelet-derived growth factor receptor alpha
Sequence:
MGAVGELVGSFSHGLESFAHGSHFVLTPPGDSGALMNEHLVSAERLSRSTSPDLTHLKGILRRRQLYCRTGYHLEILPDGSVQGTRKDHSRFGILEFISLAVGMVSIRGVDSGLYLGMNSKGELYGSEKLSAECVFREQFEENWYNTYSSNLYRHGERGSHYYVALNKDGTSRDGARSRRHQRFTHFLPRPVDPERVPELYKDVLGHS
Protein: Protein 4.2 (P4.2) (Erythrocyte membrane protein band 4.2) (Erythrocyte protein 4.2) (P16452)
Organism: Homo sapiens (Human)
Function: Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic surface of erythrocyte membranes.
Interaction partners:
- Alpha-hemoglobin-stabilizing protein
- Band 3 anion transport protein
- Ankyrin-1
- Glycophorin-B
- Ammonium transporter Rh type A
- Glycophorin-A
- Dematin
- 5-aminolevulinate synthase, erythroid-specific, mitochondrial
- Krueppel-like factor 1
- Spectrin alpha chain, erythrocytic 1
Sequence:
MGQALGIKSCDFQAARNNEEHHTKALSSRRLFVRRGQPFTIILYFRAPVRAFLPALKKVALTAQTGEQPSKINRTQATFPISSLGDRKWWSAVVEERDAQSWTISVTTPADAVIGHYSLLLQVSGRKQLLLGQFTLLFNPWNREDAVFLKNEAQRMEYLLNQNGLIYLGTADCIQAESWDFGQFEGDVIDLSLRLLSKDKQVEKWSQPVHVARVLGALLHFLKEQRVLPTPQTQATQEGALLNKRRGSVPILRQWLTGRGRPVYDGQAWVLAAVACTVLRCLGIPARVVTTFASAQGTGGRLLIDEYYNEEGLQNGEGQRGRIWIFQTSTECWMTRPALPQGYDGWQILHPSAPNGGGVLGSCDLVPVRAVKEGTLGLTPAVSDLFAAINASCVVWKCCEDGTLELTDSNTKYVGNNISTKGVGSDRCEDITQNYKYPEGSLQEKEVLERVEKEKMEREKDNGIRPPSLETASPLYLLLKAPSSLPLRGDAQISVTLVNHSEQEKAVQLAIGVQAVHYNGVLAAKLWRKKLHLTLSANLEKIITIGLFFSNFERNPPENTFLRLTAMATHSESNLSCFAQEDIAICRPHLAIKMPEKAEQYQPLTASVSLQNSLDAPMEDCVISILGRGLIHRERSYRFRSVWPENTMCAKFQFTPTHVGLQRLTVEVDCNMFQNLTNYKSVTVVAPELSA
Protein: Uncharacterized protein orf284 (Q2F959)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MTRDRMRQSIKGRALCRAFSSRSAGGVIFKVVLKSLQERKKRISSEISSTIYFYMLCIPYLIFFLKISILVFLVFYRIVLPIVQMFSLLTCCSFLITLPPEVQDPQALAHLEGLNFYLSLYEQDPEWVAFIQQELNHNTPLEDIPGRLRLFLMEERTSNVRMDLIQEFLALYARNGAVLPVEPYLLEGALRSYLDSIRATDDFSILQAAYQDLRDHEEGSFFFRDVVSHNRDFLEAQSAKRTWIEVERNSLYSKIERAQARLERTEFQHTLLIFQLEDRKRGGE
Protein: Hermansky-Pudlak syndrome 5 protein homolog (F6NLH0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|PIRNR:PIRNR037475}.
Interaction partners:
- HPS3 biogenesis of lysosomal organelles complex 2 subunit 1.
- Dystrobrevin-binding protein 1b.
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Biogenesis of lysosomal organelles complex-1, subunit 2
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- SNARE-associated protein Snapin
- HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.
- Dysbindin-A
- AP-3 complex subunit delta-1
Sequence:
MIPVVPVESCTHVLAEFDCLDPLLSALRLDSGRIKCTCLSVSRKWLALGTSAGGLHLIQRDGWKQKLILTHKEGSITQVSCCPHDEDFIAVATSQGLVVVWELHLERRGRPERASVSWEHRGVTVTSLCWDTVALRVFAGDMGGKVSCVRAGSSKLGKGSAFVIFPVQTVTTVDSRVVQLGYTDGHLVISSLSRCYLCDTEREKFWRVGNKERDGEFGACFLTQGLAGQRGQLVGCPAPLLFCARPGSRIWEASFSGEVLSTHQFKQLLAVPPLPLVSCKNEPHFNPTQTNPQSLAFPRLLQFGDQNLLTWTDSAIYIFTPHSGQVLLWTEVKDVLEISVFRNDLFCLHGDGHLSHMSLVSPDRCVERLMKRENWTIAATVCCMFQHAITTSKARKSLSIDRLEHLKAQLNSTSQQQLIGQLEEVISKLEPLDSACSSRRSSISSHESFNVLDCGIYRVISRRGSQSDDDASSLANQSMLEEERLKEFSFTEEEQVDNDSASVRGEGDRSDLGLQFLPLPFRSKPPRVALQAVRDSVSSFMKKTTEKINTLQMNADLWPRPDLREGVQGEVASTASPISEESEQELNTEESSSESELLELRAATKKAISQIQDPMVLLDPLCLSDVLQEWAPVLERALGPEDQILPVETTNPEEKTLEEEELVSSMSCCVVVQPEISTSPAADPDESATHTEEEDFRESTPCSIAPVRAQFPPLANHVELIQLFSPKPLPPDLQADLSLLACLYLEMGCPGRGGMESVCVFLRRFFFLLDQERVRRMCMLRYRENREVLKAYIAGMLEFTQASKVVEVIQKGDLLKSLRSLRELQPWNAPLLLSHLYRLYEKHGEVAVRAYPQFYPTILPSDIMAMALPSHFLPYLDNLVQSRAEQQRLSFLGSLLQPETLRQDWLELALSHDAPQREDTLTHDGQPRWHSHFFSWGYGRLLSLLIRLPADLASKQKMLDMCKAHGYWMGYLYLCRELQRRAEAFSAICRLDDMTLLEGDDGIVPQSLDEWVLLLQLSQQISASDESSLTSTKNSNGSCLDDANSNGDCSSGLSNGSTDWSIQVSPENIILRLVRVFGPDRALTALQEHGIPVDHSSRSTLVCDLLRMAEKRQRALIQSMLERCDRFLWSQHA
Protein: Uncharacterized protein C6G9.01c (Q92346)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MEIDDIFASKKANPANEKSNDSKSEAKAPKKGAKTKSTPSRPKPTNNQDDLFLDPKGASGRKRTEEGFLVYDEEELNIGQGGGTPDCPFDCQCCF
Protein: 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) (Q385D6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Glucose-6-phosphate 1-dehydrogenase
Sequence:
MSFKPTISVHATPQELSAAGCRKIVEIIETSGSQQWPLSIALAGGSTPKMTYARLHDEHLNLLREKRALRFFMGDERMVPADSTDSNYNMAREVLLHDIPDDLVFPFDTSAVTPSAEATSADAMRVAEAYGKQLASLLPLKSVGEAGAKVPVFDVVLLGLGSDGHTASIFPGSQAEKETDGKVVVSVGFPSETMKPKVWRVTLSPATIMQARNVIVLATGAEKKWVVDGILADTAHKAPVARFLRGCEGNVSFLLDKEIAENLAKF
Protein: Surfeit locus protein 4 (Q64310)
Organism: Mus musculus (Mouse)
Function: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins. Promotes the secretion of PCSK9. Also mediates the efficient secretion of erythropoietin (EPO). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein {ECO:0000255}. Note=Active at endoplasmic reticulum exit sites (ERES) where it is incorporated together with its lipoprotein cargos into COPII-coated vesicles. From the Golgi it is recycled back to the endoplasmic reticulum. {ECO:0000250|UniProtKB:O15260}.
Interaction partners:
- Golgi SNAP receptor complex member 1
- Surfeit locus protein 2
- Transmembrane emp24 domain-containing protein 2
- Protein ERGIC-53
- Vesicular integral-membrane protein VIP36
- Surfeit locus protein 1
- Golgi reassembly-stacking protein 2
- Protein RER1
- Transmembrane emp24 domain-containing protein 9
- Transmembrane emp24 domain-containing protein 10
Sequence:
MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWSCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIIQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW
Protein: Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20) (Heat shock protein family B member 6) (O14558)
Organism: Homo sapiens (Human)
Function: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus {ECO:0000269|PubMed:19464326}. Secreted {ECO:0000269|PubMed:22427880}. Note=Translocates to nuclear foci during heat shock. {ECO:0000269|PubMed:19464326}.
Interaction partners:
- BAG family molecular chaperone regulator 3
- 14-3-3 protein sigma
- Heat shock protein beta-1
- Heat shock 70 kDa protein 4
- 14-3-3 protein gamma
- 60 kDa heat shock protein, mitochondrial
- Heat shock protein beta-8
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- DnaJ homolog subfamily B member 1
Sequence:
MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPTTLAPYYLRAPSVALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK
Protein: Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1) (Q9JJZ1)
Organism: Rattus norvegicus (Rat)
Function: Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10671487}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10671487}; Multi-pass membrane protein {ECO:0000255}. Note=Principally intracellular (PubMed:10671487). May move between intracellular vesicles and the plasma membrane (PubMed:10671487). The dileucine internalization motif is critical for intracellular sequestration (PubMed:10671487). {ECO:0000269|PubMed:10671487}.
Interaction partners:
Sequence:
MSPEDPQETQPLLRSPGARAPGGRRVFLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDTAASWFGAVVTLGAAAGGVLGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLAMLRRPGVHKPLIIGICLMVFQQLSGVNAIMFYANTIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRKLLLALSGVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCILSVLFTLTFVPETKGRTLEQITAHFEGR
Protein: Kinesin-like protein KIF22 (Q3V300)
Organism: Mus musculus (Mouse)
Function: Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q14807}. Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Chromosome-associated kinesin KIF4
- Kinesin-like protein KIF2C
- Transforming acidic coiled-coil-containing protein 3
- Serine/threonine-protein kinase PLK1
- Rac GTPase-activating protein 1
- Protein regulator of cytokinesis 1
- Cell division cycle protein 20 homolog
- Aurora kinase A
- Cell division cycle-associated protein 3
- Kinesin-like protein KIF20A
Sequence:
MSLRAKTCPQRREMASATSGPGRCVSKGGLGRRPPLARVRVAVRLRPFMDGETEAKELPCVRAIDSCSLEVANWKKYQETLKYQFDAFYGEKSTQQEVYVGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLAREESAEGRPWDVSVAMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLTQKPITSFSDFEQHFLPASRNRAVGATRLNQRSSRSHAVLLVKVDQRERLTPFRQREGKLYLIDLAGSEDNRRTGNQGIRLKESGAINTSLFVLGKVVDALNQGLPRIPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALNFTARSKEVINRPFTNESLQPHALAPVKLSQKELLGPSEAKKAKGPEEESTGSPESTAAPASASQKLSLLQKLSNMDPAMLENLLSMERLLGSQGSQGTPLLNTPKRERMVLMKTVEEKNLEIERLKMKQKELEAKVLAQEAPDPREKENTPTILQPPASYSGTVAKPLKKAVVMPLQRIQKQRESSNQIQLLKKGPKRKLEPSPESEAVEKDEDYWEVQISPELLAHGRKKLLDLLNEGSARELRSLQRIGQKKAQLIVGWRELHGPFSEVEDLEQVEGISGKQVESFLKANLLSLAASQHSGPS
Protein: Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC) (P14173)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.
Interaction partners:
- Tyrosine 3-monooxygenase
- Dopamine beta-hydroxylase
- Tryptophan 5-hydroxylase 1
- Amine oxidase [flavin-containing] B
- Amine oxidase [flavin-containing] A
- Transmembrane O-methyltransferase homolog
- Catechol O-methyltransferase
- Tryptophan 5-hydroxylase 2
- Serotonin N-acetyltransferase
- Phenylalanine-4-hydroxylase
Sequence:
MDSREFRRRGKEMVDYIADYLDGIEGRPVYPDVEPGYLRALIPTTAPQEPETYEDIIRDIEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPEAFLAGRAGEGGGVIQGSASEATLVALLAARTKMIRQLQAASPELTQAALMEKLVAYTSDQAHSSVERAGLIGGVKIKAIPSDGNYSMRAAALREALERDKAAGLIPFFVVVTLGTTSCCSFDNLLEVGPICNQEGVWLHIDAAYAGSAFICPEFRYLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTEAFNMDPVYLRHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVKLSHEFESLVRQDPRFEICTEVILGLVCFRLKGSNQLNETLLQRINSAKKIHLVPCRLRDKFVLRFAVCSRTVESAHVQLAWEHIRDLASSVLRAEKE
Protein: Probable insulin-like peptide beta-type 5 (P56174)
Organism: Caenorhabditis elegans
Function: Probable insulin-like peptide which negatively regulates synapse development at the neuromuscular junctions. Probably acts as a daf-2/InsR agonist ligand to prevent dauer formation under optimal environmental conditions. Acts on AWC sensory neurons to regulate high salt chemotaxis responses.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Insulin-like peptide INSL5
- Ceinsulin-1
- INSulin related
- Insulin-like receptor
- Insulin-like peptide 17
- Dauer larva development regulatory growth factor daf-7
Sequence:
MNSVFTIIFVLCALQVAASFRQSFGPSMSEESASMQLLRELQHNMMESAHRPMPRARRVPAPGETRACGRKLISLVMAVCGDLCNPQEGKDIATECCGNQCSDDYIRSACCP
Protein: Proton:oligopeptide symporter POT family (Q8EHE6)
Organism: Shewanella oneidensis (strain ATCC 700550 / JCM 31522 / CIP 106686 / LMG 19005 / NCIMB 14063 / MR-1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Proton:peptide symporter POT family
Sequence:
MTLGTNQVSKTHSFMTVSLIELWERFGYYGMQALIVYFMVQRLGFDDSRANLVWSACAALIYVSPAIGGWVGDKILGTKRTMLLGAGILSVGYALMTVPTENTWFMFSALGVIVVGNGLFKPNAGNLVRKIYEGDDSKIDSAFTIYYMAVNVGSTFSMLLTPWIKDYVNAQYGNEFGWHAAFAVCCVGILVGLGNYALMHKSLANYGSEPDTRPVNKKSLAIVLALAALSVVASAIILEYEDVARVFVYAAGVAVLGIFFHLIRTSEPSERAGLIAALILTVQTVFFFIFYQQMSTSLALFALRNVDWDFQVFGTHLWTWSPAQFQALNPIWIMVLSPVLAWSYSWAGRNNKDFSIAAKFALGFAVVAIGFFIYGFAGQFAVNGKTSSWVMIWGYASYSLGELLVSGLGLAMIARYVPARMGGFMMGAYFVASGISQYLGGVVANFASVPQDLVDPLQTLPVYTNLFNKLGVAAVVCTIIALAVLPLMRRLTESHHAHSSIENNAAASLRDVKAEQ
Protein: cAMP-dependent protein kinase type II-alpha regulatory subunit (Q08BH1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSIEIPVGLTELLQGYTVEVLRQRPPDLVEFAVQYFTRLRDTRSQDGSGAAAKTGGKGVMFDGEPMQTESNGDEDDEDDDSDFEPPPPSRFNRRVSVCAEAFNPDDDEEDSEPRVVHPKTDEQRCRLQEACKDILLFKALDQEQFSEVLDAMFEVLVQPQDHVIDQGDDGDNFYVIERGVYDIVVQKDGVGCYVGQYNNKGSFGELALMYNTPRAATIIAKDEGALWGLDRATFRRLIVKNNAKKRRMYECFIESIPLLKSLELSERMKIVDVLGVKTFQDGERIIMQGDKADCFYIVESGEVKIMMKSKTKADRQDNAEVEIARCSRGQYFGELALVTNKPRAASAYAIGDVKCLVIDIQAFERLLGPCKEIMKRNIAHYEEQLVALFGSSVDLRD
Protein: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.59) (NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase) (P10618)
Organism: Methanothermus fervidus
Function: Exhibits a dual-cofactor specificity, with a marked preference for NADP(+) over NAD(+).
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MKAVAINGYGTVGKRVADAIAQQDDMKVIGVSKTRPDFEARMALKKGYDLYVAIPERVKLFEKAGIEVAGTVDDMLDEADIVIDCTPEGIGAKNLKMYKEKGIKAIFQGGEKHEDIGLSFNSLSNYEESYGKDYTRVVSCNTTGLCRTLKPLHDSFGIKKVRAVIVRRGADPAQVSKGPINAIIPNPPKLPSHHGPDVKTVLDINIDTMAVIVPTTLMHQHNVMVEVEETPTVDDIIDVFEDTPRVILISAEDGLTSTAEIMEYAKELGRSRNDLFEIPVWRESITVVDNEIYYMQAVHQESDIVPENVDAVRAILEMEEDKYKSINKTNKAMNILQ
Protein: Solute carrier family 52, riboflavin transporter, member 1 (Porcine endogenous retrovirus A receptor 2) (PERV-A receptor 2) (huPAR-2) (Protein GPR172B) (Riboflavin transporter 1) (hRFT1) (Q9NWF4)
Organism: Homo sapiens (Human)
Function: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12740431, ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- FAD synthase
Sequence:
MAAPTLGRLVLTHLLVALFGMGSWAAVNGIWVELPVVVKDLPEGWSLPSYLSVVVALGNLGLLVVTLWRQLAPGKGEQVPIQVVQVLSVVGTALLAPLWHHVAPVAGQLHSVAFLTLALVLAMACCTSNVTFLPFLSHLPPPFLRSFFLGQGLSALLPCVLALVQGVGRLECPPAPTNGTSGPPLDFPERFPASTFFWALTALLVTSAAAFRGLLLLLPSLPSVTTGGSGPELQLGSPGAEEEEKEEEEALPLQEPPSQAAGTIPGPDPEAHQLFSAHGAFLLGLMAFTSAVTNGVLPSVQSFSCLPYGRLAYHLAVVLGSAANPLACFLAMGVLCRSLAGLVGLSLLGMLFGAYLMALAILSPCPPLVGTTAGVVLVVLSWVLCLCVFSYVKVAASSLLHGGGRPALLAAGVAIQVGSLLGAGAMFPPTSIYHVFQSRKDCVDPCGP
Protein: Contig An16c0020, genomic contig (EC 1.11.-.-) (A2R6R3)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Interaction partners:
Sequence:
MALKPGDSFPSDVVFQYIPWSEDKGEITACGIPINYNASKEWADKKVVLFSVPGAFTPTCSINHVPGYIQNLPQLKEKGVQVVAVIASNDPFVMSAWGKANNVKGDDILFLTDPDARFSNNLGWASGGRTGRFAIVIDHGKVTYAQIETEKGAVKVSGADAILANL
Protein: 6-hydroxynicotinate reductase (EC 1.3.7.1) (Q0QLF7)
Organism: Eubacterium barkeri (Clostridium barkeri)
Function: Catalyzes the reversible reduction of 6-hydroxynicotinate to 6-oxo-1,4,5,6-tetrahydronicotinate.
Interaction partners:
- Enamidase
- Uncharacterized protein
- Pyruvate:ferredoxin oxidoreductase
- Pyruvate:ferredoxin oxidoreductase
- Nicotinate dehydrogenase medium molybdopterin subunit
- Nicotinate dehydrogenase large molybdopterin subunit
- Nicotinate dehydrogenase FAD-subunit
- Nicotinate dehydrogenase small FeS subunit
- Amino acid synthesis
- NAD
Sequence:
MFKIDEEKCKKCRMCVKECPVHAVYYEKKDKGAIVEITEKCVECGICKRVCKFGAIENDAPLESVITCSSCPIQCKVPLGETGACTRYRNVGGKLVRDRELVVEALEQKEAADNIKKPIITAVGAGTNYPCSKPAPHIVSECRDGVDVVTVVTEAPLSYSGLVIKLDTNTYIGEEGDPVYRDGKVVGMVNTEEYGSKMIAIGGANRLTGDNGFATARTIVELANGEEVELKVNKKIVLKLKAGVAPVIDGVEESIMRIGCGSATVGLFAKRMKDAVDECIVIDHHVIGLCSEHLAGEAVGMTWSGIIPNATKSSRGRYFGGHGSGIGGTSLETPRDAIKGADMSIAKAGMQVMVVNTTGEIYALFELKADGSFDEIPMTEAALGVALAIQDNCQRSMTSILYTGGTGGSARGGVCTHPVKITEAVHEQKAVLTIGGAPAFVYPGGGINFMVDTQKVVNKAFTWVPTPATVAPVEYTMTVADYEAMGGHMDQIKDVSEYK
Protein: Hypothetical proline-rich protein (O05780)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible conserved transmembrane protein
- Peptide chain release factor 2
- DUF732 domain-containing protein
- NADPH-ferredoxin reductase FprA
- SsrA-binding protein
Sequence:
MKLSNQKRHWPGYLFGRIRTSTLVLIAAFLAVWWIYETYRPQAPGPGDSPPTQVVPPGFVPDPDYTWVPRTRVQPPTVKATPTTTSSTPPVSPPETTTDSAVPPPFELPPPFGPGTTTPTPPAPLPQPGPGPTAGTYPKSEPPTR
Protein: SWR1 complex subunit 6 (Protein SERRATED LEAVES AND EARLY FLOWERING) (Q9FHW2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Coodinates SWR1-C, FRI-C (FLC transcription activator complex), histone methyltransferase and general transcription factors. Represses flowering by positively regulating FLC and MAF4. Binds to the promoter region of FLC chromatin.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:17470967}. Nucleus {ECO:0000269|PubMed:17470967}. Note=Relocates to the nuclear periphery when interacting with ARP6.
Interaction partners:
- SWR1-complex protein 4
- RuvB-like protein 1
- Actin-related protein 6
- SWR1 complex subunit 2
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- Actin-related protein 4
- RuvB-like helicase
- Transcription initiation factor TFIID subunit 14b
- Probable histone H2A variant 3
- RuvB-like helicase
Sequence:
MEEEMSNRRVSNRTRKVATKMAAALTSNDNRTQAAIARLEALENDNGAIEVIDLNDDEEASLDEDDDLGYLQKKQHKGSKRKTRQAKALEARKAPKSFLELLQEANLESLPSHVPTYLKAAVGPPSSSSRRYFCSVCGYIAGYNCCLCGMRFCSIRCQNIHKDTRCQKFVA
Protein: Chondroadherin-like protein (Q6NUI6)
Organism: Homo sapiens (Human)
Function: Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.
Subcellular location: Secreted {ECO:0000269|PubMed:25451920}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:E9Q7T7}.
Interaction partners:
Sequence:
MEGPRSSTHVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGATCATPPNARGQRVKAAAAVFEDCPGWAARKAKRTPASRPSARRTPIKGRQCGADKVGKEKGRL