wanglab/gogpt-training-data huggingface dataset:
Protein: Myocardial zonula adherens protein (GRINL1A upstream protein) (Gup) (P0CAP1)
Organism: Homo sapiens (Human)
Function: Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5EB94}. Cell membrane {ECO:0000250|UniProtKB:Q5EB94}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q5EB94}; Cytoplasmic side {ECO:0000250|UniProtKB:Q5EB94}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:Q5EB94}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q5EB94}. Cell junction {ECO:0000269|PubMed:18849881, ECO:0000269|PubMed:21240187}. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin. {ECO:0000250|UniProtKB:Q5EB94}.
Interaction partners:
- DNA-directed RNA polymerase II subunit GRINL1A
Sequence:
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT
Protein: Cyclin-dependent kinase 6 (F1MA87)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- G1/S-specific cyclin-D1
- G1/S-specific cyclin-D2
- Cyclin-dependent kinase 4 inhibitor B
- Cyclin-dependent kinase inhibitor 1B
- G1/S-specific cyclin-E1
- Cyclin-A2
- G1/S-specific cyclin-D3
- Cyclin-dependent kinase 4 inhibitor C
- Cyclin-dependent kinase inhibitor 1
- Tumor suppressor ARF
Sequence:
MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAELFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLHSHLSSSQSTSELNTA
Protein: Spectrin beta chain (A0A140UHX6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Spectrin alpha chain, erythrocytic 1
- Spectrin alpha chain, non-erythrocytic 1
- Ankyrin 2
- Ankyrin 1
- Ankyrin-3
Sequence:
MTSATEFENVGNQPPYSRINARWDAPDDELDNDSSSARLFERSRIKALADEREVVQKKTFTKWVNSHLARVSCRISDLYKDLRDGRMLIKLLEVLSGEMLPRPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPQVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFDVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTISVLNSRKFANSLSGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYQRELALRSELIRQEKLEQLARRFDRKAAMRETWLNENQRLVTQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVKALEDLAQELEKENYHDQKRISARKNNILRLWSYLQELLRSRRQRLEATLALQKLFQDMLHSIDWMDEIKAHILSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKTITAATLQFTEGKGYQPCDPQVIQDRVSHLEQCFSELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLKQIFQEAEDMVAQKQFGHPQIETRVKEVSAQWDHLKELAAFRKKDLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKEFLEELEESRGVMEHLENQAQGFPEEFRDSPDVTNRLQALRKLYQQVMAQAELRGHKLQEALDLYTVFGESDACELWMTEKGKWLDQMDIPNTLEDLEVVQHRFDILDQEMKTLMAQIDGVNLAANNLVESGHPRSGEVKQYQDRLNKRWQAFQAVVSEQREAVDSALRVNNYCVDCEETSKWIVDKTKVVESTKDLGQDLAGVIAIQRKLSGLERDVLAIRDRVSALERESQYLMESHPDQKEDIGQRQADVEKMWKGLQDALQGQELSLGEASKLQAFLQDLDDFKAWLSMAQKAVASEDMPESLPEAEQLLQQHAAIKEEIDAHKDDYHRVKASGEKVIEGQTDPDYQLLGQRLEGLDTDWDALWRMWESRGNTLTQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLAAAEAGIRKFEDFLVSMENNRDKVLSPVDSGNMLVSEGNLYSNKIKEKVQLIEDRHMKNNEKAQEVTALLKDNLELQNFLQNCKELTLWINDKLLTSPDISYDEARNLHNKWMKHQAFMAELASHQGWLENIVAEGRQLMAEKPQFTDVVSERLEALHKLWDELQTTTKAKTEQLSAARSSDLRLQTHADLSKWISAMEDQLRSDDLGKDLTTVNRMLVKLKRVEEQVNLRKEELEELFAEAPPLGAEAGDTDMSIEKRFLDLLEPLGRRKKQLELSKAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHAPRVEDVLHRGQELVKAAEIDCQDIEERLGHLQSSWDTLREAAAGRLQRLREAHEAQQYYLDAGEAEAWISEQELYVFSDEPPKDEEGAIVMLKRHLRQQRTVEEYGRNIKQLAGRAQSLLSAGHPEGEQIIRLQGQVDKQYAGLKDMAEERRRKLENMYHLFQLKREADDLEQWITEKEMVASSQEMGQDFDHVTMLRDKFRDFARETGAIGQERVDNVNSIIERLIDAGHSEAATIAEWKDGLNDMWADLLELIDTRMQLLAASYDLHRYFYTGTEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKADAIQSKEQEVSAAWQALLDACAGRRAQLVDTADKFRFFSMVRDLLSWMESIIRQIETQERPRDVSSVELLLKYHQGIKAEINTRAKNFSTCLELGESLLQRQHQASDEIREKLQQVISRRQEMNDKWEARSDRLHMLLEVCQFSRDASVAEAWLIAQEPYLASRDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQTPDRPTEEPGPQEEEGETAGEAPQVHHAATERTSPDA
Protein: Programmed cell death protein 4 (Protein I11/6) (Q98TX3)
Organism: Gallus gallus (Chicken)
Function: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:11313950}. Cytoplasm {ECO:0000269|PubMed:11313950}. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions.
Interaction partners:
- Eukaryotic initiation factor 4A-II
- Phosphatase and tensin homolog
Sequence:
MEIEKQHVYISTVEVENLSDALFSGDEENGGSEERKTEINGNWIPATSITEAKINAKAKRRLRKNSSRDSGRGDSVSENGETQKAGLVVPTSPKGKVLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDIKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVSEMLKDLNLGEMKYSVPVLAVSLALEGKASHREMTSKLISDLCGTVVSKTDVEKSFDKLLKDLPDLVLDSPRAPQLVGQFIARAVGDGILSSTYIDGYKGTVDSIQARAALDRATVLLSVTKGGKRIDNVWGSGGGQQSVKHLVKEIDMLLKEYLLSGDLLEAERCLQELEVPHFHHELVYEAIVMVLESTGEKTFKMMLDLLKSLSRSSVITMDQMKRGYERVYCEIPDINLDVPHSYSVLERFVEECFQAGIISKPLRDLCPSRGRKRFVSEGDGGRLKPESY
Protein: Tachykinin-4 (Preprotachykinin-C) (PPT-C) [Cleaved into: Endokinin-A (EKA); Endokinin-A/B (EKA/B); Endokinin-C (EKC)] (Q86UU9)
Organism: Homo sapiens (Human)
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Substance-P receptor
- Protachykinin-1
- Substance-K receptor
- Choline/ethanolamine kinase
- Tachykinin-3
- Neuromedin-K receptor
Sequence:
MLPCLALLLLMELSVCTVAGDGGEEQTLSTEAETWVIVALEEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKAYQLEHTFQGLLGKRSLFTEGREDEAQGSE
Protein: Testican-1 (Protein SPOCK) (Q62288)
Organism: Mus musculus (Mouse)
Function: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- SPARC
Sequence:
MPAIAVLAAAAAAWCFLQVDSRHLDALAGGAALNNANFLDNDQWLSTVSQYDRDKYWNRFRDGIQDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKGNVAHKHWLGPSNLVKCKPCPVAQSAMVCGSDGHTYTSKCKLEFHACSTGKSLNSLCDGPCPCLPEPEPLKPKAEKSACTDKELRNLASRLKDWFGALHEDANRVIKPTSSDPAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDHSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPAGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGTVSCEEEQETSGDFGSGGSVVLLDDLEDERELGPKDKEGKLRVRTRAVREDDEDEDDDKEDEVGYIW
Protein: Toxic shock syndrome toxin-1 (TSST-1) (P06886)
Organism: Staphylococcus aureus
Function: Responsible for the symptoms of toxic shock syndrome.
Subcellular location: Secreted {ECO:0000269|PubMed:6226876}.
Interaction partners:
Sequence:
MNKKLLMNFFIVSPLLLATTATDFTPVPLSSNQIIKTAKASTNDNIKDLLDWYSSGSDTFTNSEVLDNSLGSMRIKNTDGSISLIIFPSPYYSPAFTKGEKVDLNTKRTKKSQHTSEGTYIHFQISGVTNTEKLPTPIELPLKVKVHGKDSPLKYGPKFDKKQLAISTLDFEIRHQLTQIHGLYRSSDKTGGYWKITMNDGSTYQSDLSKKFEYNTEKPPINIDEIKTIEAEIN
Protein: Nitrogen regulatory protein P-II (PII signal transducing protein) (Q55247)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme (By similarity).
Interaction partners:
- Acetylglutamate kinase
- Putative ammonium transporter sll0108
- Putative ammonium transporter sll1017
- Putative ammonium transporter sll0537
- Global nitrogen regulator
- Glutamine synthetase
- Ferredoxin-dependent glutamate synthase 2
- Glutamate--ammonia ligase
- Ferredoxin-dependent glutamate synthase 1
- Probable RNA polymerase sigma-C factor
Sequence:
MKKVEAIIRPFKLDEVKIALVNAGIVGMTVSEVRGFGRQKGQTERYRGSEYTVEFLQKLKIEIVVDEGQVDMVVDKLVSAARTGEIGDGKIFISPVDSVVRIRTGEKDTEAI
Protein: Disabled homolog 1 (O75553)
Organism: Homo sapiens (Human)
Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P97318}.
Interaction partners:
- Very low-density lipoprotein receptor
- Reelin
- SH3 domain-containing kinase-binding protein 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 3-kinase regulatory subunit gamma
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Low-density lipoprotein receptor-related protein 8
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Sequence:
MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSNGYSFEDFEERFAAATPNRNLPTDFDEIFEATKAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQAGS
Protein: Cytokinin dehydrogenase 5 (EC 1.5.99.12) (Cytokinin oxidase 5) (OsCKX5) (Q5ZAY9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group.
Subcellular location: Secreted, extracellular space {ECO:0000250}.
Interaction partners:
- Nitrate reductase
- Nitrate reductase
- Nitrate reductase 1
- Malate synthase
- Succinate dehydrogenase iron-sulfur subunit 1, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 2, mitochondrial
- NADP-dependent glyceraldehyde-3-phosphate dehydrogenase])
- Cytochrome c oxidase subunit 3
Sequence:
MAWCLVFMVFLIYCLISTVGLPVAPADEAAMQLGGVGGGRLSVEPSDVMEASLDFGRLTSAEPLAVFHPRGAGDVAALVKAAYGSASGIRVSARGHGHSISGQAQAAGGVVVDMSHGWRAEAAERTLPVYSPALGGHYIDVWGGELWIDVLNWTLAHGGLAPRSWTDYLYLSVGGTLSNAGISGQAFHHGPQISNVYELDVVTGKGEVVTCSESNNPDLFFGALGGLGQLGIITRARIALEPAPHRVRWIRALYSNFTEFTADQERLISLQHGGRRFDYVEGFVVAAEGLINNWRSSFFSPQNPVKLSSLKHHSGVLYCLEVTKNYDDSTAVTVDQDVEALLGELNFIPGTVFTTDLPYVDFLDRVHKAELKLRGKGMWEVPHPWLNLFVPASRIADFDRGVFRGVLGSRTAGGPILIYPMNRHKWDPRSSVVTPEEDVFYLVAFLRSAVPGSTDPAQSLEALERQNREILEFCDEAGIGAKQYLPNHKAQREWEAHFGARWARFARLKAEFDPRAMLATGQGIFDSPPLLAES
Protein: Thioredoxin-like fold domain-containing protein (Q4GYY9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MRCCSTALRTGRRGPGGWTEPRLQQATSTDFMRDSTGTGGDNNNNNNNDGGKGPSSALKRHFNVNDFSMIERQQMTLTKLMRITMDATFKPKDPDSRTYGGDGATQRAALREELKTMDSRIVPFAHEEILNDYLKNIVELSGPSGQRYDREMLRGRLVGLLFFTETDRSLAFMRLLREFHQRHRRDFVVVAISLGGKEMMDITRQHGFYHCSHRDGATWVQRDTGLMVRPWTPLPRLIVVNGTSGEEITSSGVTAVKAHPNTCFEKWKNGEEGCDWWDYIKTFYM
Protein: Nuclear pore complex protein Nup75 (Nucleoporin Nup85) (A1YK07)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000256|ARBA:ARBA00004567, ECO:0000256|RuleBase:RU365073}.
Interaction partners:
Sequence:
MSDSGVFAFELGDDLATRCGNTLTGVFVPGSRIALSAYRHVTHSSRDEPTENAGQVPVLIYMAQESTLFDEPVLRSVLAEANATFATLQQLGSRATRAEYVNISRAYRSIVRSCLEKLEQAKKSPEVQTDEARLQRLCDAIVVFYAAECLWHLFEILYIQSNQLVVPQLLDWARFHSPHAEDRATDLLLMGEEASESDDYWSIVKSLIMLGEIDVTRAVLSQNRKAGQTSFKAAEQILKSMPVYQEGYALQKFHSQWEFWHVDTERKIQSGLFATEPELEQLIRLVAGDSEQWDAGIKESQDFYEYLPGYLLFTKPTCKPFELKIAAAKWLNRWCLLRPEREQCSMNRMVSQLMDHDLRLFIYDAQKLNDTHWFSTHLIDLIHHCGQLKSYFDQNNIDLPALRHSMIYEYGSYLMTSHNMWQLGIDYLDCCKQEGQAAIELLLPRITLRSERQATKLINLARQRGLISVEREICKVLSKRSYDNERYGNALEWAIRSKDVLLVTAVADFILKHYSKTGCMLCPDTIANVGGRMFXSPRLVFLSKYFEFYEFYRTRDFLSASELLVNLLESKITPDYFWPSLLIDSMPLLESKDPKIFAKETVAILHHIETDLVPIIERDVSKYGKHHTETVFKDYRVENVDEIMNLLRLACARNLARALIIENTLPVV
Protein: CSC1-like protein At1g11960 (B5TYT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as an osmosensitive calcium-permeable cation channel.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Serine/threonine-protein kinase BIK1
Sequence:
MATLGDIGVAAAINILTAIIFLLAFAILRIQPFNDRVYFPKWYLKGIRSSPLHSGALVSKFVNVNLGSYLRFLNWMPAALKMPEPELIDHAGLDSAVYLRIYLIGLKIFVPIALLAWSILVPVNWTSHGLQLAKLRNVTSSDIDKLSISNIENGSDRFWTHLVMAYAFTFWTCYVLMKEYEKVAAMRLAFLQNEQRRPDQFTVLVRNVPADPDESISDSVEHFFLVNHPDHYLTHQVVYNANDLAALVEQKKSTQNWLDYYQLKYTRNQEHKPRIKTGFLGLWGKKVDAIDHYIAEIEKLNEQIMEERKKVKKDDTSVMPAAFVSFKTRWGAAVSAQTQQSSDPTEWLTEWAPEAREVFWSNLAIPYVSLTVRRLIMHIAFFFLTFFFMIPIAFVQSLASIEGIEKNAPFLKSIIENDLFKSVIQGFLPGIVLKLFLIFLPSILMVMSKFEGFVSLSSLERRAAFRYYIFNLINVFLGSVITGSAFEQLDSFLKQSAKEIPKTVGVAIPIKATFFITYIMVDGWAGIAGEILRLKPLIFFHIKNSLLVKTEKDREEAMNPGQINYHATEPRIQLYFLLGLVYAPVTPVLLPFIIIFFALAYLVFRHQIINVYNQEYESAARFWPDVHGRIISALIIAQILLMGLLSTKGAAQSTPFLLFLPIITFFFHRYCKGRYEPAFLRHPLKEAMVKDTLERAREPNFNLKPYLQKAYIHPVFKDNDYEDSRFDEISGYCIEDSDEECVTVPTKRQSRINTPAVSHASRGSSRSPPSK
Protein: V-type proton ATPase subunit F (V-ATPase subunit F) (Vacuolar proton pump subunit F) (O43046)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
Subcellular location: Vacuole membrane {ECO:0000250|UniProtKB:P39111}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- V-type proton ATPase subunit G
- V-type proton ATPase subunit D
- V-type proton ATPase subunit C
- Probable V-type proton ATPase 20 kDa proteolipid subunit
- V-type proton ATPase subunit H
- V-type proton ATPase subunit a
- V-type proton ATPase subunit B
- V-type proton ATPase subunit d
- V-type proton ATPase subunit E
- V-type proton ATPase subunit c'
Sequence:
MSSQSYRERTLVSVIGDDDTVTGMLLAGTGQVNENGDKNFFIITQKTTDEQIAEAFDDYTTKRKDIAIVLINQFAAERIRDRIENHVQAFPAVLEIPSKDDPYDPEKDSILRRVRKIIGE
Protein: Pleckstrin (Platelet 47 kDa protein) (p47) (P08567)
Organism: Homo sapiens (Human)
Function: Major protein kinase C substrate of platelets.
Interaction partners:
- Proto-oncogene DBL
- Tyrosine-protein kinase BTK
- Cytohesin-1
- Oxysterol-binding protein 1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
- Proto-oncogene tyrosine-protein kinase Src
- RAC-alpha serine/threonine-protein kinase
- Guanine nucleotide exchange factor MSS4
- Cell division control protein 42 homolog
- Transforming protein RhoA
Sequence:
MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQDFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRLPETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMIASSLLNEGYLQPAGDMSKSAVDGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVILKEEFRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK
Protein: Opsin (Q401Q1)
Organism: Pieris rapae (Small white butterfly) (Artogeia rapae)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MELNYTAGDPIAFPFKMVSGEVQQHMLGWNIPAEHQGLVHEHWRQFPAVDKFSHYLLALIYFILMIFSVTGNSLVIWIFSTSKSLRSASNMFIVNLAIFDLTMMLEMPHLIVNSFYQTIIGNQMGCDIYAVFGALSGIGGAITNAVIAYDRYKTISCPIDGRINKVQASILIAVTWMWALPFTILPWTRVWGQYTTEGFLTTCSFDFLSEDQDTKAFVACIFCWSYVIPMTLICTFYSKLFVAVRHHERMLKEQAKKMNVKSLASNKEDAGKSVEIRIAKVAFTIFFLFICSWTPYGVVTMIGAFGDRSLLTPVVTMIPAVFCKAVSCIDPWVYAINHPRFRAELERRVPWMGVREPDPDATSTNASTSTTPADA
Protein: Homeobox protein prospero homolog 1 (Homeobox protein ceh-26) (P34522)
Organism: Caenorhabditis elegans
Function: Transcription factor involved in developmental processes (By similarity). Controls the transcription of genes required for excretory canal formation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- RanBD1 domain-containing protein
Sequence:
MSSGLPSIAATAQPSANGFSFNNGFPPFGIYYSQLPPVNSNGSTPNSSNRFKVKRHRQRVDAGEPRNTYQGASTSVSSNSSSSSSTSNTNSTPSSSSTSSKKSTEGMTETETMTASIEQEKVIQNEESEAGKDGMEEHDDGMNDFEIIDDTNDEVEESEERESPESNSSSASKRKSFQPQKIGEELGIEFGDETEQINVTVGGTEEAEETTDEAEGRELSALQAQLQNGHIAEQQRRFYAAFLDQQRKQVAAAQILHNGKINIERLVSSVKGDLVTNFMKDLEKVIRDWAADEVLKQEAAAPPQIPQPPPQFHPIFPANPLFHMAPPHHPVAGGGIFPPNFNAFNAFNALRRNLQDVDTSSEMKKKRTKVEIKKEDAMSSRASPLSASASPPLSRFFPAPTMVGHYGGMNFGDREDSPTNSDELSECGYEGGGSSSMLTPMHLRKAKLMFFYTRYPNSNLLKSYFPDIRFNKNNTAQLVKWFSNFREFYYNQMEKFARQALAEGITDRNDIFVSKDSELFKVLNTHYNRNNHIKAPDRLVFVVQETLREFHDAIKQGKDIEPSWKKTIYKVINRLEDQIPDFFKEPNFLERLET
Protein: Protein UL31 (P16848)
Organism: Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Function: Plays a role in the inhibition of host innate immune system by targeting host CGAS and promoting dissociation of DNA from CGAS, thereby inhibiting the enzymatic activity of CGAS.
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:29937271}. Host nucleus {ECO:0000269|PubMed:29937271}.
Interaction partners:
Sequence:
MGDKPTLVTLLTVAVSSPPPSSPLPLVSFTELLLPPPSVAAAAVAATATSEVGEKTAEQEVAAADPETGNERRENRENEGGETRTTGTTAVKRSHDGIPRQLAERLRLCRHMDPEQDYRLPAQDVVTSWIEALRDADRDNYGRCVRHAKIHRSASHLTAYESYLVSITEQYNTASNVTEKASYVQGCIFLSFPVIYNNTQGCGYKYDWSNVVTPKAAYAELFFLLCSTSESSVVLQPLITKGGLCSSMAVYDEETMRQSQAVQIGFLHTQLVMVPFVPHACPHYAVPFTTPGKPGCGGAPSGVAGLEEAAPFGRVSVTRHGATLLCRVDHLTWISKRVTTYGHKKITRYLAQFRGTMDDDEAALPGEDEAWIASKNVQYEFMGLIFTVNVDSLCVDAEQRQLLGTVATSFCHRVSDKITARNMPRAFSFYLLTSAQRGYDLRFSRNPSLFFSGDALNCPLLNEPNVFSLTVHAPYDIHFGVQPRQTVELDLRYVQITDRCFLVANLPHEDAFYTGLSVWRGGEPLKVTLWTRTRSIVIPQGTPIATLYQITEGDGNVYSYNHHTVFRQMHAAGTTTFFLGDMQLPADNFLTSPHP
Protein: Enriched in surface-labeled proteome protein 13 (Q57UQ6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTVKVSFSLTTAAMLLLIPMPTLSKNCFATPRDNNSTDEEQLGTSKHVITFSGDKWGGVYTGGERKLKTALLLDIYAQILRRHAFDTTADINDVNTRGKHMSVTVTITQVLINGTPSEKMQHTWNPSEISSLLMQGTYKHTNNLYNEYGGNSETGSNGAVRLLSVKNPTISEKLHRCGEGCAALRTFSGVILFFMALVSAICVFLIFKWRRDAEKEEDEEEEEEDIPTPNKHAVNVLNVDDARMETESNEGISDSNSADNNPK
Protein: Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) (P42892)
Organism: Homo sapiens (Human)
Function: Converts big endothelin-1 to endothelin-1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:37835445}; Single-pass type II membrane protein.
Interaction partners:
- Endothelin-1
- Endothelin-3
- Endothelin-1 receptor
- Endothelin receptor type B
- Endothelin-2
- Insulin-degrading enzyme
- Amyloid-beta precursor protein
Sequence:
MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
Protein: Elongation factor 1-beta (EF-1-beta) (Eukaryotic elongation factor 1Balpha) (eEF1Balpha) (Translation elongation factor 1B alpha) (P32471)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A. The 30-fold higher concentration of GTP compared to GDP in cells favors the formation of eEF1A-GTP, which rapidly forms a ternary complex with aminoacyl-tRNA that in turn displaces eEF1B from the complex.
Interaction partners:
- Elongation factor 1-gamma 2
- Elongation factor 1-gamma 1
- Elongation factor 1-alpha
- Translationally-controlled tumor protein homolog
- Small ribosomal subunit protein RACK1
- Putative elongation factor 1 gamma homolog
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS19
Sequence:
MASTDFSKIETLKQLNASLADKSYIEGTAVSQADVTVFKAFQSAYPEFSRWFNHIASKADEFDSFPAASAAAAEEEEDDDVDLFGSDDEEADAEAEKLKAERIAAYNAKKAAKPAKPAAKSIVTLDVKPWDDETNLEEMVANVKAIEMEGLTWGAHQFIPIGFGIKKLQINCVVEDDKVSLDDLQQSIEEDEDHVQSTDIAAMQKL
Protein: Probable proteasome subunit beta type-6 (Q9UQY2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809, ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable proteasome subunit alpha type-5
- Probable proteasome subunit beta type-3
- Probable proteasome subunit beta type-4
- Probable proteasome subunit beta type-2
- Probable proteasome subunit beta type-1
- Probable proteasome subunit alpha type-3
- Probable proteasome subunit beta type-7
- Probable proteasome subunit beta type-5
- Probable proteasome subunit alpha type-4
- 26S proteasome regulatory subunit rpn11
Sequence:
MSQSQFDPYVQNGGTTVAIAGDGFAILAGDTRSVNGYNINTRFQPRVHEVGDDLVIGASGFEADALALVKRIQQRIDLYHDNHERKMSAQSCACMVRTLLYGKRFFPYYVYTTVAGIDKEGKGEIYSFDPVGSYEREWCRAGGSAANFITPFLDNQVNLHNQYVPGSHGKERKPRRLLKLEEAMKITTDAFTSAGERHIEVGDSVLVKIITKEGVETRIIPLKKD