wanglab/gogpt-training-data huggingface dataset:
Protein: Sister chromatid cohesion protein PDS5 homolog A (Precocious dissociation of sisters protein 5-A) (AtPDS5A) (PDS5) (B6EUB3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cohesin cofactor dispensable during the meiotic division but playing an important role in DNA repair by homologous recombination (HR) probably by helping SMC5/SMC6 complex. Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication (By similarity). Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
Sequence:
MAQKPEEQLKELGSKLDLAPVSKDSLLKLLKEAAVCLSELEQSPPPAVLKSIQPFLDAVIKPEILNHQDKDVKLLVASCVSEITRITAPEAPYSDNIMKDIFQLIVSAFAGLNDVSGPSFGRRVLILETVAKYRSCVVMLDLECDDLVKEVFTTFLDVARDDHPEIVFSSMQNIMIVLLEESEDVQEHLLLILLSKLGRNRSDVRDAARRLAMKVIEHCAPKVESDIKQFLISSMSGDSRFSSSQIDYHEVIYDLYRCAPQALSGVAPYLTGELLADKLETRLKVVGLVGELFSLPGRVISEEFDSIFLEFLKRLTDRVVEVRMAILDHIKDCLLSDPLRAEASQIISALCDRLLDYDENIRKQVVAVICDVSVSALTSIPVDTMKLVAERLRDKAILVKTYTMERLTELFRVYCLRCADGKVDTGDFNWIPGKILRCLYDKDFRSDTIEYILCSSLFPSDFSVRDKVKHWIQIFSGFDKVETKAFEKILEQRQRIQQEMQRYLSIKQTQQTADAPEIQKKILFGFRVMSRAFSDPPKTEQNFLILDQLKDANIWKILTNLLDPNTSITQASRIRDDMLKILSEKHSLYDFLSTLSIKCSYLLFSKEYVKEILAEVSVRKSSKNTLGIQPCMDFLGLLACFCPSLFDGAEEELISFLKDDDEMMKEGTLKILAKAGGTIRENLIVLASSVDLLLERICVEGNRKQAKYAVHALASITKDDGLKSLSVLYKRLVDMLEDKRYQPAVLQCLGCIAQIAMPVYETRESEVVEFIRSKILKLKSETVDDKKLSWDDKSEICQLKIYGIKTLVKSYLPFKDAQLRAGVDDLLGILKNILSFGEVSEDLESSSVDKAHLRLAAAKAVLRLSRHWDDKIPIEIFHLTLKTPEIPFPTAKKIFLGKVHQYVKDRVLEMKYACSFLFDITGSNVLESEEDKHNLADIIQHSYQTKVRKISAQTDANSVTLYPHHILPYLVHALAHHSCPDVEKCKDVKEYEMIYRQLYLIISMLLHKEEDGKTEDIDKEREYVPTIILIFHSIKQSEDVTDATKSKNSHAICELGLSIINHLTQKEPDLQGEITPVSLPPTLYKPSEKVEGDKSQVGEEKLWLADETVLLHFRALKLESHADASVIPQTSENEVMIDGESDGNEIPLGKIVERLRAQGTKTRKGKKNKSVPAEDENGKNDVDVLKMVREINLDHLQMLDKFESSNGHKHSPSERAEICQRDQKGNKRNVGDATSVVSVPKRRRSSSGHSPYKFSNSGPKVQLKASEDELHLESDMDKNVSLDSHDENSDQEKMLESISPRKRKKSLSSKLKITESDWALTDVERSRSAGGGDSKLKSASGSMKKRKNVSGLAKCSTKENKLVNDELIGCRIEVWWPMDKRFYEGTVKSYDSTKQRHVILYEDGDVEVLNLKKEQWELIDTGGKTAKKSRTSKGNSKKKRSSGSKPKNPDGVQRDEDPVTTTPKGKRTPKKNLKQLHPKDTPKSLSLEHEKVESRNKKRRSSALPKTEYSGEAGEEKSESEGKSLKEGEDDEEVVNKEEDLQEAKTESSGDAEGKEAEHDDSDTEGKQENNEMEREAEENAETSDNETLGAWKSKVGKSISRTAI
Protein: Uncharacterized protein (G5EAZ5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Psi-producing oxygenase A
- Lysophospholipase
- Patatin-like phospholipase domain-containing protein
Sequence:
MLRRFSTFRKSKGDKTEKADRDSKANGSNANSAAAASNSSKRQSKVPPPRRPSSDSGSSAESEDVPAVFEKYAQVLHASSRPIPHQGGEAAYLEKEHPSGLFNDLKSLGFKDFASLKDVIKTKINGELTDDKTMIMERIIQIVSSLPSNSKMRVDLTNMFLDELWGSLPHPPLSYMGNDYQYRSADGSNNNPTLPWLGAANTAYARSIEPLTVQPGGLPDAGLVFDTLFARQKFTPHPNKVSSLFFDWASLIIHDIFQTDYRDYNKNKTSAYLDLAILYGDVQEEQDLVRTHKDGKLKPDSFSEPRLQAFPAACCVLLVMLNRFHNYVVEELAAINENGRFTKPSPDLPEEQAKKAWAKYDEDLFQTGRLITCGLFINITLYDYLRTIVNLNRVNSTWCLDPRAQMEGSATPAGLGNQCSVEFNLAYRWHSAISANDEKWTEKVYEELIGKPGSEISTQELLMGLGKYGASLPKDPSQRTFAGLKRQEDGTFKDEELVNILTSAIEDVAGSFGARNVPKVLKAVEVLGIEQGRKWNVGSLNEFRKFFGLKNYETFEEINSDPEVAESLRALYGHPDYVELYPGIVSEEAKEPMIPGVGIAPTYTISRAVLSDAVALVRGDRHYTVDYNPRNLTNWGYNEVRYDLNINQGCVFYKLATRAFPNWFKPDSIYAHYPMTIPSENKVIMKNLGREADYSWDRPQYQAPRASLTSYSNVKLILDQQKDFRVVWGDCTPLHSGKGGEDFWSKTLSDPQFKKSIKEFYEKTTLELFADKSVNLAGRKQIDIVKDVGNIVPARFASKLLSLPLRSKENSKGVFTDHEIFMALAVIYNAIFFDVDTTKSFPLRKAADAVSKELGKHVESHVKSVSSPGFLSRVIDNFRDDHNALKDLGDQLIKRLAEGGLSVSDITYGQILPTAVELVHGQAQMFTRVVEYYLNEGKQHLPELSLLAKQDSAETDAKLTRYALEAIRLNAGSGAYRKAETNFYFKEGDADINLKPGDEIFISSTQANRDPTAFPDPDEVRLDRPDESYLNYGIGSQIGLGKDATLTAVTAMVRAAFSLEGLRPAPGVQGVLKKVVRPEGYTLYMREDHGAFSPFPTTFRVHFDGEVVTPKKQIDSA
Protein: Protein lin-7 homolog (Q9VBY7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cell membrane {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}.
Interaction partners:
Sequence:
MADNAEPLTLSRDVKRSIELLEKLQASGDFPTTKLAALQKVLNSDFMTSVREVYEHVYETVDIQGSHDVRASATAKATVAAFAASEGHAHPRVVELPKTEEGLGFNVMGGKEQNSPIYISRIIPGGVADRHGGLKRGDQLLSVNGVSVEGENHEKAVELLKQAVGSVKLVVRYTPKVLEEMEMRFDKQRNTRRRQ
Protein: Fibroblast growth factor (FGF) (Q9DFC9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Fibroblast growth factor receptor 1-A
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor 3
- Platelet-derived growth factor receptor alpha
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor kdr-like
- Angiopoietin-1 receptor
- Mast/stem cell growth factor receptor kita
- Platelet-derived growth factor receptor, beta polypeptide
Sequence:
MSVQSALLPILVLGLMTSSVRCAPLPGGHSGPVERRWETLYSRSLARIPGEKRDISRDSDYLTGIKRLRRLYCNVGIGFHLQVLPGGKITGVHNENRYSLLEISPVERGVVTLFGVRSGLFVAMNSKGKLYGSEQFTNECKFREKLLANNYNAYESLAHPGMYIGLSKAGKTKKGNRVSTSMTMTHFLPRI
Protein: Cation diffusion facilitator family protein 1 (Q95QW4)
Organism: Caenorhabditis elegans
Function: Involved in the regulation of Pn.p cell fate determination. Involved in zinc metabolism and the decrease of the cytosolic zinc concentration which is thought to modulate Ras signaling. Involved in zinc transport from the intestinal lumen to the pseudocoelum.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:12015965, ECO:0000269|PubMed:23717214}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- SUppressor of activated let-60 Ras
- Histidine ammonia-lyase
- Zinc transporter ZIP3
- Zinc transporter ZIP8
Sequence:
MEVTMEDRSVKADKADRDDNNTTSTELLGKMRQTKVISTNQNNNHLIDRMVSIYEMEMIKSQSTETISDVSDVLEFTVIDNCSHGTHTLEHDLRLKGEPIGKSESVKGVSRSLIIQIGMTVIFCALEFITGVVCSSIAMLADSYHMAADVMALIVAFTCIKIATRPSTRLGYGWVRAETLGGFFNGIFMCTVCVLVFQEAVGRIINVHMITHPLQVLVIGFIGLLINLFGMFNLSGHGHSHGGGSHGHSHGGSHGHSHNNKKTKKNDGHGHSHANGHGHSHDGKSDCNGEEEPDHTRLNGKFRSASAMANSDANVRLLDNDDNSNDIIERRLSGVNSQNTIIATVDRQMTPYGTHMASEVLNVSSNNLDKSAQKTEQKKDKNVNIHGVWLHLLSDAFGSVIVMISAGFVYFLPTWKIAAYLDPILSISLASIMGFTAVVLVKTSGEKLLKQTPEGLDLEKVKKDLCSIVGVSKVEKLSVWTLCGQRIIAAAHVNICHPAVFPEAAYKIKNYFHDLGVHSTTIEPTFEDTCMQSMRIMVKKVVDGKSIEEPVSVSTENEITE
Protein: Shaven, isoform F (Q59DN8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLIMDIQTSTHHIHGLGTHELQHRILHPHILHSTQEETLNTSTGQLEHDSQHLQQHHLTHHQQQDVSPTLHNLQNTRTGDSLSTTINTNQNQHGHQHLSGSNMYTSSQMEDKSKANKYDEYSSRTLSNISDANTTPSANNFITQSQGIEWITAMNDIQNGAEDSHSSQGSISGDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSINRIVRNKAAEKAKHVHHHQQHHVSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSANSVNTNVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGIQHGHHSHNNNNNSSVNNNNNTESSCKRKRIEAHDENHDTNIHSDNDDGKRQRMSTYSGDQLYTNIWSGKWCIKDDHKLLAELGNLTASTGNCPATYYEASNGFSTTPISGSGATASGNDTSMLYDSITTISQTQSSIYTPAIGPSIGTGSLTPLVPISMHEMKLSANSIQEQTVPPFYTALAFDGNYTSMTSLENCSSLVGQEHIVMPESSDSNTLCPISTRIVPDITETNSTRVKEPLTNSDGCSEDNNKEPEKSNSSQSSDHIASPHLHHIGEEQLRGNRRSNLNASTHPSSLIPLQPSGGSSLLNINPSENRSDVELNLSNNVGLYSTPTVLPSFNHYSAGCSSVVPGSDYAYNPAYTQYGGAYGSYGYGTGSGLISN
Protein: Anti-sigma-K factor RskA (Regulator of SigK) (Sigma-K anti-sigma factor RskA) (P9WGX5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- ECF RNA polymerase sigma factor SigK
- Amine oxidase domain-containing protein
- Cell surface glycolipoprotein MPT83
- Immunogenic protein MPT70
Sequence:
MTEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAFNDEVRAVRETMAVVSAATTAEPPAHLRTAILDATKPEVRRQSRWRTAAFASAAAIAVGLGAFGLGVLTRPSPPPTVAEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNVAPPSRGTVYQMWLLGGAKGPRSAGTMGTAAVTPSTTATLTDLGASTALAFTVEPGTGSPQPTGTILAELPLG
Protein: proton-translocating NAD(P)(+) transhydrogenase (EC 7.1.1.1) (Q5BJZ3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- NAD kinase
- NAD kinase 2, mitochondrial
- Nicotinamide-nucleotide adenylyltransferase
- NAD-dependent protein deacetylase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- NAD-dependent protein deacetylase sirtuin-1
- NAD-dependent protein deacylase sirtuin-5, mitochondrial
- NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Sequence:
MAHLLKTVVTGCLCPSVSNLGSCKVLPGKKDFLRTFRTHQALWCKSPAKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQALVKQGFNVVVESGAGEASKFPDDLYRAAGAQIQGTKEVLASDLVVKVRAPMVNPTLGAHEADFLKPSGTLISFIYPAQNPDLLNKLSERKTTVLAMDQVPRVTIAQGYDALSSMANISGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAVVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFSKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYVHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFHFEVKDDFDFGTMSHVIRGTVVMKDGNVIFPAPTPKNIPKEAPAKQKTVAELEAEKAGTVSMYTKTLRTASVYSAGLTGMLGLGIVAPNLAFSQMVTTFGLAGIIGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLALMGGHFYPSTTSQSLAALATFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLLPGGTFVGGYLAALYGGYNIEEIMYLGSGLCCVGALGGLSTQGTARLGNALGMIGVAGGLAATLGGLKPDPQLLAQMSGAMAMGGTIGLAIAKRIQISDLPQLVAAFHSLVGLAAVLTCMAEYIVEYPHFAMDATSNFTKIVAYIGTYIGGVTFSGSLVAYGKLQGILKSAPLLLPGRHALNAGLLAASVGGIIPFMADPSFTTGIMCLGSVSALSTLMGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAVEMIREANSIVITPGYGLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINSDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK
Protein: Bidirectional sugar transporter SWEET2b (OsSWEET2b) (Q5N8J1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8L9J7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
Interaction partners:
Sequence:
MDSLYDISCFAAGLAGNIFALALFLSPVTTFKRILKAKSTERFDGLPYLFSLLNCLICLWYGLPWVADGRLLVATVNGIGAVFQLAYICLFIFYADSRKTRMKIIGLLVLVVCGFALVSHASVFFFDQPLRQQFVGAVSMASLISMFASPLAVMGVVIRSESVEFMPFYLSLSTFLMSASFALYGLLLRDFFIYFPNGLGLILGAMQLALYAYYSRKWRGQDSSAPLLLA
Protein: Huntingtin-interacting protein M (Histone H2A.P) (Huntingtin yeast partner M) (O75409)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSEKKNCKNSSTNNNQTQDPSRNELQVPRSFVDRVVQDERDVQSQSSSTINTLLTLLDCLADYIMERVGLEASNNGSMRNTSQDREREVDNNREPHSAESDVTRFLFDEMPKSRKND
Protein: Ubiquitin/ribosomal protein S27a, putative (Q38B98)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Polyubiquitin, putative
- 40S ribosomal protein S15, putative
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S25
- 40S ribosomal protein S13, putative
- 60S ribosomal protein L19, putative
- 40S ribosomal protein S33, putative
- 40S ribosomal protein S24
- 40S ribosomal protein S17, putative
- 40S ribosomal protein S5, putative
Sequence:
MLVFVKLAGGKTTAVQTAADDTVASVRAKAGLGENDLLFYGGECLCDGALLCDYALKRESTIQAMLPVEGGKGKKKKKKVFTKPKKPIHRHKLEKMRALKYFKVTENDDGSFKVERTRDECPNPNCGAGVFMAQHKGRKYCGKCHLTYTMK
Protein: Pygopus homolog 1 (Q9Y3Y4)
Organism: Homo sapiens (Human)
Function: Involved in signal transduction through the Wnt pathway.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- B-cell CLL/lymphoma 9 protein
- Histone H3.1t
- Histone H3.3
- Histone H3.1
- Histone H3.2
- Histone H3-7
- Histone H3.3C
- Catenin beta-1
- B-cell CLL/lymphoma 9-like protein
- Lymphoid enhancer-binding factor 1
Sequence:
MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNPAENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQDFTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPANGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA
Protein: Polynucleotide kinase 3'-phosphatase (A0A0D9SFL2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEETRTPESQPDTPPGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITTRSGKVFPTGPSDWRILYPEIPRKLRELEAEGYKVLVATHAGLYRKPVTGMWDHLQEQANDGTPISIGDSIFVGDAAGRPANWAPGRKKKDFSCADRLFALNLGLPFATPEEFFLKWPAAGFELPAFDPRTVSRSGPLCLPESRALLSASPEVVVAVGFPGAGKSTFLKKHLVSAGYVHVNRDTLGSWQRCVTTCETALKQGKRVAIDNTNPDAASRARYVQCARAAGVPCRCFLFTATLEQARHNNRFREMTDSSHIPVSDMVMYGYRKQFEAPTLAEGFSAILEIPFRLWVEPRLGRLYCQFSEG
Protein: M6, isoform F (M9PGC0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFCSNAERGPLSWCHWHPAFGIWSKACGPKPRWQSTLELHSVWHRHRGTSALCSMPGKGNNRDRIRDPREEILLETNFEDDGGVLTRAYNGNPYNPTIQNRRRNSYRSDHSLDRYTERGGEGECCQSCMARIPYATLIATLMCLLGVGIFCFTMYRGASLTVIMVDQVFHLRLIWIEAVQMIFVIIGAGMAALGFMILFVGFLATGATRYKVYRAWRSRVGGRISCAVLMGITYLLNFVWSLILCFLVVVTFIYTMFWNMCTSVEHSQSCIDLTQFHFMFPPNTKLEDMKVCEKYEIKAFCKDGVENAEVMFILATLSTLLVLLSLVHYLMCLSANYAHIRDHEKFQELQEIQNLNELEYSATSKDRF
Protein: Appetite-regulating hormone isoform X1 (Preproghrelin-1) (B3IYK1)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLLKRNTGLMILMLCTLALWAKSVSGGSSFLSPSQKPQVRQGKGKPPRVGRRDIESFAELFEGPLHQEDKHNTIKAPFEMGITMSEEEFQEYGAVLQKILQDVLGDTATAE
Protein: Protein costars (Q558Y7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Modulates actin dynamics and cell motility.
Interaction partners:
- RING-type domain-containing protein
Sequence:
MDVDHEVKELVKFIKKLGTKGADGKYSVKYGVLFNDDDVANFFEALVGTLKAAKKRGIITFQGEILLQRVHDNVDVILLKDE
Protein: Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) (P35439)
Organism: Rattus norvegicus (Rat)
Function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1350383, ECO:0000269|PubMed:1388270, ECO:0000269|PubMed:15996549, ECO:0000269|PubMed:18177891, ECO:0000269|PubMed:1834949, ECO:0000269|PubMed:21389213, ECO:0000269|PubMed:24876489, ECO:0000269|PubMed:27135925, ECO:0000269|PubMed:27618671, ECO:0000269|PubMed:28384476, ECO:0000269|PubMed:28468946, ECO:0000269|PubMed:8428958}; Multi-pass membrane protein {ECO:0000269|PubMed:24876489, ECO:0000269|PubMed:27135925}. Postsynaptic cell membrane {ECO:0000269|PubMed:26041915}. Synaptic cell membrane {ECO:0000269|PubMed:15312654}. Postsynaptic density membrane {ECO:0000269|PubMed:26041915}. Note=Synaptic cell membrane targeting is dependent of GRIN2B/GluN2B subunit (By similarity). Association with GRIN3A occurs in the endoplasmic reticulum (PubMed:11160393). {ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:11160393}.
Interaction partners:
- Disks large homolog 4
- Glutamate receptor ionotropic, NMDA 3A
- Glutamate receptor ionotropic, NMDA 2D
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor ionotropic, NMDA 3B
- Calmodulin-like protein 3
- Calmodulin-like protein 4
- Calmodulin-1
Sequence:
MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
Protein: Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) (Q8HYE4)
Organism: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Function: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P00352}. Cell projection, axon {ECO:0000250|UniProtKB:P24549}.
Interaction partners:
- Aldehyde oxidase 2
- Uncharacterized protein.
- Aldehyde oxidase 1
- NADP-retinol dehydrogenase
- Uncharacterized protein.
- Alcohol dehydrogenase 4
- Retinol dehydrogenase 10
- Aldehyde dehydrogenase 1 family member A3
- Cytochrome P450 family 26 subfamily B member 1
- NADP-retinol dehydrogenase
Sequence:
MSSSGTSDLPVLPTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGATQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTNDIDKAVTISSALQAGTVWVNCYGVVTAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS
Protein: Solute carrier family 13 member 1 (NaSi-1) (Renal sodium/sulfate cotransporter) (Na(+)/sulfate cotransporter) (Q9JHI4)
Organism: Mus musculus (Mouse)
Function: Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine. Can also mediate the transport of selenate and thiosulfate (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q07782}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sulfate transporter
- Sulfate anion transporter 1
Sequence:
MKLLNYALVYRRFLLVVFTILVFLPLPLIIRTKEAQCAYILFVIAIFWITEALPLSITALLPGLMFPMFGIMRSSQVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALRMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIVEAVAQQIISAEAEAEATQMTYFNESAAHGLDIDETVIGQETNEKKEKTKPAPGSSHDKGKVSRKMETEKNAVTGAKYRSRKDHMMCKLMCLSVAYSSTIGGLTTITGTSTNLIFSEHFNTRYPDCRCLNFGSWFLFSFPVALILLLLSWIWLQWLYLGFDFKMFKCGKTKTLKEKACAKVIKQEYEKLGPMRYQEIVTLVIFIVMALLWFSRDPGFVTGWSVLFSEYPGYVTDSTVALVAGILFFLIPAKKVTKMTSAGEIIAFDYTPLITWKEFQSFMPWDIAILVGGGFALADGCQVSGLSNWIGSKLSPLGSLPVWLIILISSLIVTSLTEVASNPATITILFPILSPLAEAIQVNPLQILLPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNILGVAVVMLGMFTWIEPMFNLHEYPSWASNFVNQTMP
Protein: Sensor histidine kinase component HK1 (EC 2.7.13.3) (O07778)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Member of the three-protein two-component system HK1/HK2/TcrA. Kinase that binds ATP and catalyzes the transfer of a phosphoryl group from ATP to HK2.
Interaction partners:
- Transcriptional regulatory protein TcrA
- Sensor histidine kinase component HK2
- Transcriptional regulatory protein PrrA
- Transcriptional regulatory protein TrcR
- DNA-binding response regulator MtrA
- Probable transcriptional regulatory protein TcrX
- Sensory transduction protein RegX3
- Response regulator MprA
- Possible two component system response transcriptional positive regulator PhoP
- Transcriptional regulatory protein KdpE
Sequence:
MPITPLLHESVARFAATGADITTRAEPDLFVSIDPDHLRRILTAVLDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRFTRADTARGGRGSGLGLAIVAALTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRITSSDTKDPNREHDTSDQ
Protein: Ent-kaurene oxidase, chloroplastic (AtKO1) (EC 1.14.14.86) (Cytochrome P450 701A3) (Q93ZB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes three successive oxidations of the 4-methyl group of ent-kaurene giving kaurenoic acid, a key step in gibberellins (GAs) biosynthesis. GAs, which are involved many processes, including stem elongation, play a central role in plant development.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000269|PubMed:11722763}; Single-pass membrane protein {ECO:0000269|PubMed:11722763}.
Interaction partners:
- Ent-kaur-16-ene synthase, chloroplastic
- Ent-kaurenoic acid oxidase 2
- Ent-kaurenoic acid oxidase 1
- Ent-copalyl diphosphate synthase, chloroplastic
- Gibberellin 3-beta-dioxygenase 1
- Gibberellin 20 oxidase 1
- Gibberellin 2-beta-dioxygenase 2
- Gibberellin 3-beta-dioxygenase 2
- Gibberellin 2-beta-dioxygenase 1
- Gibberellin 20 oxidase 3
Sequence:
MAFFSMISILLGFVISSFIFIFFFKKLLSFSRKNMSEVSTLPSVPVVPGFPVIGNLLQLKEKKPHKTFTRWSEIYGPIYSIKMGSSSLIVLNSTETAKEAMVTRFSSISTRKLSNALTVLTCDKSMVATSDYDDFHKLVKRCLLNGLLGANAQKRKRHYRDALIENVSSKLHAHARDHPQEPVNFRAIFEHELFGVALKQAFGKDVESIYVKELGVTLSKDEIFKVLVHDMMEGAIDVDWRDFFPYLKWIPNKSFEARIQQKHKRRLAVMNALIQDRLKQNGSESDDDCYLNFLMSEAKTLTKEQIAILVWETIIETADTTLVTTEWAIYELAKHPSVQDRLCKEIQNVCGGEKFKEEQLSQVPYLNGVFHETLRKYSPAPLVPIRYAHEDTQIGGYHVPAGSEIAINIYGCNMDKKRWERPEDWWPERFLDDGKYETSDLHKTMAFGAGKRVCAGALQASLMAGIAIGRLVQEFEWKLRDGEEENVDTYGLTSQKLYPLMAIINPRRS