wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome P450, family 706, subfamily A, polypeptide 4 (Flavonoid 3', 5'-hydroxylase-like protein) (Putative cytochrome p450) (Putative flavonoid 3',5'-hydroxylase) (Q9STI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- NAD
- Putative ion channel POLLUX-like 2
- 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 3
- UDP-glycosyltransferase 91B1
- NAD
- Aldo-keto reductase family 4 member C11
Sequence:
MSPISNLFPDNTINLTPYAIVILTTVFSILWYIFKRSPQPSLPPGPRGLPIVGNLPFLDPDLHTYFANLAQSHGPIFKLNLGSKLTIVVNSPSLAREILKDQDINFSNRDVPLTGRAATYGGIDIVWTPYGAEWRQLRKICVLKLLSRKTLDSFYELRRKEVRERTRYLYEQGRKQSPVKVGDQLFLTMMNLTMNMLWGGSVKAEEMESVGTEFKGVISEITRLLSEPNVSDFFPWLARFDLQGLVKRMGVCARELDAVLDRAIEQMKPLRGRDDDEVKDFLQYLMKLKDQEGDSEVPITINHVKALLTDMVVGGTDTSTNTIEFAMAELMSNPELIKRAQEELDEVVGKDNIVEESHITRLPYILAIMKETLRLHPTLPLLVPHRPAENTVVGGYTIPKDTKIFVNVWSIQRDPNVWENPTEFRPERFLDNNSCDFTGANYSYFPFGSGRRICAGVALAERMVLYTLATLLHSFDWKIPEGHVLDLKEKFGIVLKLKIPLVALPIPRFSDSNLYL
Protein: Xanthine dehydrogenase 1 (AtXDH1) (EC 1.17.1.4) (Q8GUQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Key enzyme involved in purine catabolism. Catalyzes the oxidation of hypoxanthine to xanthine and the oxidation of xanthine to urate. Regulates the level of ureides and plays an important role during plant growth and development, senescence and response to stresses. Possesses NADH oxidase activity and may contribute to the generation of superoxide anions in planta.
Interaction partners:
- Uricase
- Xanthine dehydrogenase 2
- Hypoxanthine phosphoribosyltransferase
- Allantoinase
- Molybdenum cofactor sulfurase
- Allantoate deiminase
- Sorbitol dehydrogenase
- Monothiol glutaredoxin-S17
- Cyclic pyranopterin monophosphate synthase, mitochondrial
Sequence:
MGSLKKDGEIGDEFTEALLYVNGVRRVLPDGLAHMTLLEYLRDLGLTGTKLGCGEGGCGACTVMVSSYDRKSKTSVHYAVNACLAPLYSVEGMHVISIEGLGHRKLGLHPVQESLASSHGSQCGFCTPGFIMSMYSLLRSSKNSPSEEEIEECLAGNLCRCTGYRPIVDAFRVFAKSDDALYCGVSSLSLQDGSTICPSTGKPCSCGSKTTNEVASCNEDRFQSISYSDIDGAKYTDKELIFPPELLLRKLTPLKLRGNGGITWYRPVCLQNLLELKANYPDAKLLVGNTEVGIEMRLKRLQYQVLISVAQVPELNALNVNDNGIEVGSALRLSELLRLFRKIVKERPAHETSACKAFIEQLKWFAGTQIRNVACIGGNICTASPISDLNPLWMASRAEFRITNCNGDVRSIPAKDFFLGYRKVDMGSNEILLSVFLPWTRPLEYVKEFKQAHRRDDDIAIVNGGMRVFLEDKGQQLFVSDASIAYGGVAPLSLCARKTEEFLIGKNWNKDLLQDALKVIQSDVVIKEDAPGGMVEFRKSLTLSFFFKFFLWVSHNVNNANSAIETFPPSHMSAVQPVPRLSRIGKQDYETVKQGTSVGSSEVHLSARMQVTGEAEYTDDTPVPPNTLHAAFVLSKVPHARILSIDDSAAKSSSGFVGLFLAKDIPGDNMIGPIVPDEELFATDVVTCVGQVIGVVVADTHENAKTAAGKVDVRYEELPAILSIKEAINAKSFHPNTEKRLRKGDVELCFQSGQCDRVIEGEVQMGGQEHFYLEPNGSLVWTVDGGSEVHMISSTQAPQKHQKYVSHVLGLPMSKVVCKTKRIGGGFGGKETRSAFIAAAASVPSYLLNRPVKLILDRDVDMMITGHRHSFLGKYKVGFTNEGKILALDLEIYNNGGNSLDLSLSVLERAMFHSDNVYEIPHVRIVGNVCFTNFPSNTAFRGFGGPQGMLITENWIQRIAAELNKSPEEIKEMNFQVEGSVTHYCQTLQHCTLHQLWKELKVSCNFLKARREADEFNSHNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVYTDGTVLVTHGGVEMGQGLHTKVAQVAASAFNIPLSSVFVSETSTDKVPNASPTAASASSDMYGAAVLDACEQIIARMEPVASKHNFNTFTELVSACYFQRIDLSAHGFHIVPDLGFDWISGKGNAFRYYTYGAAFAEVEIDTLTGDFHTRAADIMLDLGYSLNPAIDVGQIEGAFVQGLGWVALEELKWGDAAHKWIKPGSLLTCGPGNYKIPSINDMPFNLNVSLLKGNPNTKAIHSSKAVGEPPFFLASSVFFAIKEAIKAARTEVGLTDWFPLESPATPERIRMACFDEFSAPFVNSDFYPNLSV
Protein: FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4) (Q969Z0)
Organism: Homo sapiens (Human)
Function: Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:28335001}.
Interaction partners:
- Probable ATP-dependent RNA helicase DDX56
Sequence:
MAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTSSATSPISHLPGSLMEPVEKERASTPYIEKQVDHLIKKATRPEELLELLGGSHDLDSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKCLELVEHFGPNELRKVLVMLAAQSRRSVPLLRAISYHLVQKPFSLTKDVLLDVAYAYGKLSFHQTQVSQRLATDLLSLMPSLTSGEVAHCAKSFALLKWLSLPLFEAFAQHVLNRAQDITLPHLCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQKDQNTFQKLLHINATALLEYPEYSGPLLPASAVAPGPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKAVAEELAK
Protein: Epithelial membrane protein 1 (EMP-1) (Tumor-associated membrane protein) (P54848)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MLVLLAGLFVVHIATAIMLFVSTIANVWMVADGIDSSIGLWKNCTSGSCDGSLSYGNDDAIKAVQAFMILSIIFSIISLVVFVFQLFTMEKGNRFFLSGSTMLVCWLCILIGVSIYTHHYAHSEGNFFPSSHQGYCFILTWICFCFSFIIGILYMVLRKK
Protein: Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (P17764)
Organism: Rattus norvegicus (Rat)
Function: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P24752}.
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
- Trifunctional enzyme subunit alpha, mitochondrial
- Hydroxymethylglutaryl-CoA lyase, mitochondrial
- Peroxisomal bifunctional enzyme
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Acetoacetyl-CoA synthetase
- Citrate synthase, mitochondrial
Sequence:
MAALAVLHGVVRRPLLRGLLQEVRCLGRSYASKPTLNDVVIVSATRTPIGSFLGSLASQPATKLGTIAIQGAIEKAGIPKEEVKEVYMGNVIQGGEGQAPTRQATLGAGLPIATPCTTVNKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMSRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKLSISREEQDKYAIGSYTRSKEAWDAGKFANEITPITISVKGKPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAAVVLMTAEAAQRLKVKPLARIAAFADAAVDPIDFPLAPAYAVPKVLKYAGLKKEDIAMWEVNEAFSVVVLANIKMLEIDPQKVNVHGGAVSLGHPIGMSGARIVVHLAHALKQGEFGLASICNGGGGASAVLIEKL
Protein: Conjugal transfer protein (A1YBN2)
Organism: Aeromonas veronii
Interaction partners:
Sequence:
MKQIKQTPLKKGRTEPVMRMYPDYQFHVSDNVVFTADKKALASIAIEGMPFESISDGVLESDFDSIKNFLVNMGKDGDVYLWTHLVKEKVSLDEEYHFKSDFLNRFSNQYTELFRGSNFFKSTYYLTFGIKYSNISEAIERLDEVIHQAKAVLGKYGAHVLTVDQNRVSGVADYLHLLLNKSHAEIPLSINPISSSIADSEWYFGYDSLELRNNEAEEKKFATNYVVKDFPMFTELGQWDFLLRLPYEFIITQSFIYEAPTKTLKEIDAQLNKMGSAGDAAENQQDELVLGKEVVTSGITLFGSYHCVLTVFGRTADEARKNGIKVSSEFVSAGKGFRFIRTNSAGAHCYFSHMPMNKIRPLATRRTITNLACTFSLHNYSHGKKRGNPIGDGTAIMPLKTVADGLYWFNTHYSEPGRDVRGQKIAGHAMILGATGAGKTTFEGAAAGFLQRFDPYMFVVDFNRSTELFVRAYGGSYFTLKEGEYTGLNPFQICDLDDELAPRLVQFLKSYVKTLAYDQSGKPCSDAQAEELAKAVDATMLLPREMRRLSTLLSRISDPELKIRLAKWCGAGQYAWAVDSPRNTFNPMDFKKVGFDTTVILEKTKDGVHPACEPLLAILFFYKSLMQREGQLMLSIIEEFWMPANFPLTQAMIKSALKAGRMKGEMMWLTSQSPEDAIYCEIFPALVQQTATKILLPNPDADLEGYKKIGLTVKEFDRLKKLGKESRTMLIKQSGSSCFAKMDLYGFDDFLPIISGSMEGITLCEKVRAELGTDNPDIWIPEFLKQLREE
Protein: VCAN protein (Versican) (Q86W61)
Organism: Homo sapiens (Human)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRKCLIPF
Protein: Insulin-induced gene 1 protein (INSIG-1) (Q8BGI3)
Organism: Mus musculus (Mouse)
Function: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (By similarity). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (By similarity). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O15503}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15503}.
Interaction partners:
- Sterol regulatory element-binding protein cleavage-activating protein
- E3 ubiquitin-protein ligase AMFR
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Sterol regulatory element-binding protein 2
- Isopentenyl-diphosphate Delta-isomerase 1
- Lanosterol 14-alpha demethylase
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Insulin-induced gene 2 protein
- Lanosterol synthase
- Membrane-associated progesterone receptor component 1
Sequence:
MPRLHDHVWNYPSAGAARPYSLPRGMIAAAACPQGPGVPEPEHAPRGQRAGTTGCSARPGSWHHDLVQRSLVLFSFGVVLALVLNLLQIQRNVTLFPDEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGVPEKPHSD
Protein: Killer cell lectin-like receptor 5 (Lymphocyte antigen 49e) (Ly-49e) (T-cell surface glycoprotein Ly-49E) (Q60652)
Organism: Mus musculus (Mouse)
Function: Receptor on natural killer (NK) cells for class I MHC.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
Sequence:
MSEPEVTYSTVRLHKSSGLQRLVSHEEIQGPGEAGYRKCSVPWQLTVRSLGIFCFLLLVTVAVLAVKIFQYSQHKQEIHETLNHNHNCSNMQSDIKLKEEMLRNKSIDCSPGEELLESLNREQNRWYSETKTDLDSSQDTGTGVKHWFCYGTKCFYFIMSKNTWSGCKQTCQHYSLPLVKIEDEDELKFLQFQVISDSYWIGLSYDKKKKQWAWIDNGPSKLDMKTRKMNFKPGGCIFLSKTRLEDTNCNNSYFCICGKKLDHFPG
Protein: Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4) (P19013)
Organism: Homo sapiens (Human)
Interaction partners:
- Keratin, type I cytoskeletal 13
- Cornulin
Sequence:
MIARQQCVRGGPRGFSCGSAIVGGGKRGAFSSVSMSGGAGRCSSGGFGSRSLYNLRGNKSISMSVAGSRQGACFGGAGGFGTGGFGGGFGGSFSGKGGPGFPVCPAGGIQEVTINQSLLTPLHVEIDPEIQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSGFGLSSGFGSGSGSGFGFGGSVSGSSSSKIISTTTLNKRR
Protein: ARM-repeat/Tetratricopeptide repeat (TPR)-like protein (Q0WMT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein SOSEKI 2
- PHD finger-like domain-containing protein 5A
- Putative F-box protein At5g51000
- Uncharacterized protein
- Probable protein phosphatase 2C 25
- Protein trichome birefringence-like 45
Sequence:
MDKASSQECPYPGCFFCVMKEGNPSKRRSCILKFFRDLPSQDDDGQVLPISGLWNTAMAHPNDPEFIELGIFECMSALIWKGLKNRRWLSHDQNIYIPYYAAHIIGSYTMNMEEFAERAVEAGVIPPLVELLRGRLTWVEQRVAVRALGHLATYPSTFPAVADHGEILELAIQLAMSSLEIVYSHFYQYPDRRLSYHCDLLTRGMGGVEMESRKAEEWASQLQCWSLQLINCFAFKPEFLPTLCKPEFLVNLPVMWGGLVNENSPAGIGLLRTICQHKLGRGPVSACAGMIEALCNIARSSDDWQYMAIECLLWLLQDPNTSHKVIDKAVPTLVDLAEITNLGDHKKLGDSIVSVLQECSSMGNRSRELIEETVNSRQRLKWEKSMPKEDLHIKQAAALVVKLEGNSLFSSGDIAGAAEKYSEALSLCPMRSKKERVVLYSNRAQCHLLLQQPLVAISDATRALCLHNPVNRHAKSLWRRAQAYDMLGLAKESLLDAILFINECSQSNDPDLSMRQNKVPDYAERLVKKQMRAAWLFKEAALKHGGVHRKGEEREVYGNETDDSEWETASESDIGDDGRDHMGLDDEEEEEEDEGHGEKWKNRDKSSEKNEKTSAKGMRHGYSIKLAEDEI
Protein: Uncharacterized protein (Q5A1M5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MQGSYNNNGLPRPYYMKPSKKKSSPYSNLKEPIVYFNNPKRKLVGYIIMFSLIGILMWWISQDFKGRPEVEYELVKNEKSGEKNTPMDLKNSANLDKIVNAVGSKADKESENLDLAENLSEGSKGQKGIGVAEAPKGGIANEAPVVGNDEEELVGTGKGGQKQQKADGNPKGKGYKASIGKTGDKDSVPAGAGAPAGVDSPKGKAEPVPDVEDAAAAARLSNEDTVQQIIEDTA
Protein: Defensin-like protein 2 (Low-molecular-weight cysteine-rich protein 69) (Protein LCR69) (Plant defensin 2.2) (Q39182)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Confers broad-spectrum resistance to pathogens.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Defensin-like protein 19
- Defensin-like protein 18
- Defensin-like protein 13
- Defensin-like protein 249
- Defensin-like protein 14
- Defensin-like protein 17
- Defensin-like protein 182
- NDR1/HIN1-like protein 1
Sequence:
MKLSMRLISAVLIMFMIFVATGMGPVTVEARTCESQSHRFKGTCVSASNCANVCHNEGFVGGNCRGFRRRCFCTRHC
Protein: Gasdermin-A3 (Gasdermin-3) [Cleaved into: Gasdermin-A3, N-terminal (GSDMA3-NT); Gasdermin-A3, C-terminal (GSDMA3-CT)] (Q5Y4Y6)
Organism: Mus musculus (Mouse)
Function: Precursor of a pore-forming protein involved in the transition from catagen to telogen at the end of hair follicle morphogenesis. This form constitutes the precursor of the pore: upon cleavage, the released N-terminal moiety (Gasdermin-A3, N-terminal) binds to membranes and forms pores, triggering cell death. This form acts as a sensor of infection: activation is triggered by cleavage by some bacterial effector protein, which releases the N-terminal moiety (Gasdermin-A3, N-terminal) (By similarity).
Subcellular location: [Gasdermin-A3]: Cytoplasm, cytosol {ECO:0000269|PubMed:27281216}.; SUBCELLULAR LOCATION: [Gasdermin-A3, N-terminal]: Cell membrane {ECO:0000269|PubMed:27281216}; Multi-pass membrane protein {ECO:0000269|PubMed:29695864}. Mitochondrion membrane {ECO:0000305|PubMed:26100518}; Multi-pass membrane protein {ECO:0000269|PubMed:29695864}.
Interaction partners:
- Gasdermin-E
Sequence:
MPVFEDVTRALVRELNPRGDLTPLDSLIDFKHFRPFCLVLRKRKSTLFWGARYVRTDYTLLDLLEPGSSPSDLTDSGNFSFKNMLDVQVQGLVEVPKTVKVKGTAGLSQSSTLEVQTLSVAPSALENLKKERKLSADHSFLNEMRYHEKNLYVVMEAVEAKQEVTVEQTGNANAIFSLPSLALLGLQGSLNNNKAVTIPKGCVLAYRVRLLRVFLFNLWDIPYICNDSMQTFPKIRRVPCSAFISPTQMISEEPEEEKLIGEMHEDFKTLKEEVQRETQEVEKLSPVGRSSLLTSLSHLLGKKKELQDLEQKLEGALDKGQKVTLEALPKDVLLSKDAMDAILYFLGALTELTEEQLKILVKSLEKKILPVQLKLVESTLEQNFLQDKEGVFPLQPDLLSSLGEEELTLTEALVGLSGLEVQRSGPQYAWDPDTRHNLCALYAGLSLLHLLSRKSNALTYCALS
Protein: TACC2 protein (B2RWP4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECRATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEIREAAHPTDVSISKTALYSRIGTTEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS
Protein: Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (B0UXP9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P12268}. Nucleus {ECO:0000250|UniProtKB:P12268}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P12268}. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion. {ECO:0000250|UniProtKB:P12268}.
Interaction partners:
- GMP synthase
- 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.
- Adenylosuccinate synthetase isozyme 2
- Adenylosuccinate synthetase
- Adenylosuccinate synthetase isozyme 1
- AMP deaminase
- AMP deaminase
- AMP deaminase
- AMP deaminase
- Inosine triphosphate pyrophosphatase
Sequence:
MADYLISGQTGYVPDDGLTGQQLFNSGDGLTYNDFLILPGYIDFTADQVDLTSALTKQITMKTPLISSPMDTVTESGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKRYEQGFITDPVVMSPNERVRDVFQAKARHGFCGIPITDNGQMGGRLVGIISSRDIDFLKESEHDLPLSEVMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNEEGCLVAIIARTDLKKNRDFPLASKDSRKQLLCGAAIGTHNDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKEKYPNVQVIGGNVVTAAQAKNLIDAGADALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQTVGHIAKALALGASTVMMGSLLAATSEAPGEYFFSDGIRLKKYRGMGSLDAMDKNLGSQTRYFSESDKIKVAQGVSGAVQDKGSIHKFVPYLLVGIQHSCQDIGAKSLTQLRAMMYSGELRFEKRTMSAQMEGGVHSLHSYEKRLF
Protein: Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) (Q6DT37)
Organism: Homo sapiens (Human)
Function: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15194684}. Note=Concentrates at the leading edge of cells.
Interaction partners:
Sequence:
MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGGDADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP
Protein: Forkhead box protein I1 (Forkhead transcription factor i1) (Q804B2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MFLEGERIMNAFGQQPSSQQTSPLQQQDILDMTVYCDSNFSMYQQNLHHHHHHHHHQRPPAHPSSYGLGEYSSPSTNPYLWMNSPGITSTPYLSSPNGGSYIQSGFGSNQRQFLPPPTGFGSADLGWLSISSQQELFKMVRPPYSYSALIAMAIQNAQDKKLTLSQIYQYVADNFPFYKKSKAGWQNSIRHNLSLNDCFKKVARDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRRADGNAMSVKSEDALKLADTSSLMSASQPSLQNSPTSSDPKSSPSPSAEHSPCFSNFIGNMNSIMSGNAVRSRDGSSAHLGDFTQHGMSGHEISPPSEPGHLNTNRLNYYSASHNNSGLINSISNHFSVNNLIYHRDGSEV
Protein: Intersectin 1 (F8W7U0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQ