wanglab/gogpt-training-data huggingface dataset:
Protein: WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) (P61964)
Organism: Homo sapiens (Human)
Function: Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.
Subcellular location: Nucleus {ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:34850113}.
Interaction partners:
- Histone H3.1
- Histone H3.2
- Protein dpy-30 homolog
- KAT8 regulatory NSL complex subunit 1
- Retinoblastoma-binding protein 5
- Histone H3.3
- Histone H3.1t
- Histone H3-7
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Histone-lysine N-methyltransferase 2C
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Protein: Carboxylesterase B (EC 3.1.1.-) (P9WHR5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Glutamine synthetase
- Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
- Probable carboxylesterase Culp3
- Phospholipase Culp4
Sequence:
MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCREFIADTSEIRTARCATVSVPVDYDQPGGTQAKLAVIRVPATGQRFGALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDAEFDAYRRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDMVRQALGDDQINYLGYSYGTELGTAYLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQWVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINALYSPQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADPAAWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPLITFDGTQHTAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP
Protein: Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (Q9VRQ9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a glutaminyl-peptide cyclotransferase. Responsible for the biosynthesis of pyroglutamyl peptides (By similarity). Might be more efficient in the conversion of tri and tetrapeptides in vitro. Might have a relative preference for substrates containing hydrophobic amino acids in vitro.
Subcellular location: Secreted {ECO:0000269|PubMed:17722885}.
Interaction partners:
Sequence:
MAIGSVVFAAAGLLLLLLPPSHQQATAGNIGSQWRDDEVHFNRTLDSILVPRVVGSRGHQQVREYLVQSLNGLGFQTEVDEFKQRVPVFGELTFANVVGTINPQAQNFLALACHYDSKYFPNDPGFVGATDSAVPCAILLNTAKTLGAYLQKEFRNRSDVGLMLIFFDGEEAFKEWTDADSVYGSKHLAAKLASKRSGSQAQLAPRNIDRIEVLVLLDLIGARNPKFSSFYENTDGLHSSLVQIEKSLRTAGQLEGNNNMFLSRVSGGLVDDDHRPFLDENVPVLHLVATPFPDVWHTPRDNAANLHWPSIRNFNRVFRNFVYQYLKRHTSPVNLRFYRT
Protein: Trigger factor (TF) (EC 5.2.1.8) (PPIase) (P9WG55)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00303}. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm. {ECO:0000255|HAMAP-Rule:MF_00303}.
Interaction partners:
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL4
Sequence:
MKSTVEQLSPTRVRINVEVPFAELEPDFQRAYKELAKQVRLPGFRPGKAPAKLLEARIGREAMLDQIVNDALPSRYGQAVAESDVQPLGRPNIEVTKKEYGQDLQFTAEVDIRPKISPPDLSALTVSVDPIEIGEDDVDAELQSLRTRFGTLTAVDRPVAVGDVVSIDLSATVDGEDIPNAAAEGLSHEVGSGRLIAGLDDAVVGLSADESRVFTAKLAAGEHAGQEAQVTVTVRSVKERELPEPDDEFAQLASEFDSIDELRASLSDQVRQAKRAQQAEQIRNATIDALLEQVDVPLPESYVQAQFDSVLHSALSGLNHDEARFNELLVEQGSSRAAFDAEARTASEKDVKRQLLLDALADELQVQVGQDDLTERLVTTSRQYGIEPQQLFGYLQERNQLPTMFADVRRELAIRAAVEAATVTDSDGNTIDTSEFFGKRVSAGEAEEAEPADEGAARAASDEATT
Protein: Pectinesterase 5 (PE 5) (EC 3.1.1.11) (Pectin methylesterase 5) (AtPME5) (Pectin methylesterase 67) (AtPME67) (Protein VANGUARD 1) (Q5MFV8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in the modification of cell walls via demethylesterification of cell wall pectin. Plays an important role in growth of pollen tubes in female floral tissues, possibly via enhancing the interaction between the pollen tube and female floral tissues by modification of the cell walls. May be regulated by MYB80 during anther development and play a role in tapetum and pollen development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15659637}. Secreted, cell wall {ECO:0000269|PubMed:15659637}. Golgi apparatus membrane {ECO:0000269|PubMed:19144003}. Note=Distributed in the whole pollen tube, including the plasma membrane and pollen tube wall (PubMed:15659637). Cleaved in the Golgi apparatus by SBT6.1 (S1P) after the Arg-Arg-Leu-Leu (RRLL) and Arg-Lys-Leu-Met (RKLM) motifs. This processing is required for extracellular targeting (PubMed:19144003). {ECO:0000269|PubMed:15659637, ECO:0000269|PubMed:19144003}.
Interaction partners:
- Pectinesterase inhibitor 3
- Pectinesterase inhibitor 1
- Pectinesterase inhibitor 5
- Pectinesterase inhibitor 2
- Probable galacturonosyltransferase 13
- Expansin-B5
- Aldehyde oxidase GLOX1
- Sialyltransferase-like protein 1
- Cellulose synthase-like protein D1
- Probable galacturonosyltransferase 14
Sequence:
MIGKVVVSVASILLIVGVAIGVVAYINKNGDANLSPQMKAVRGICEATSDKASCVKTLEPVKSDDPNKLIKAFMLATRDAITQSSNFTGKTEGNLGSGISPNNKAVLDYCKKVFMYALEDLSTIVEEMGEDLNQIGSKIDQLKQWLTGVYNYQTDCLDDIEEDDLRKTIGEGIASSKILTSNAIDIFHTVVSAMAKLNLKVEDFKNMTGGIFAPSDKGAAPVNKGTPPVADDSPVADPDGPARRLLEDIDETGIPTWVSGADRKLMTKAGRGSNDGGARIRATFVVAKDGSGQFKTVQQAVNACPEKNPGRCIIHIKAGIYREQVIIPKKKNNIFMFGDGARKTVISYNRSVKLSPGTTTSLSGTVQVESEGFMAKWIGFKNTAGPMGHQAVAIRVNGDRAVIFNCRFDGYQDTLYVNNGRQFYRNIVVSGTVDFIFGKSATVIQNSLIVVRKGNKGQFNTVTADGNEKGLAMKIGIVLQNCRIVPDKKLAAERLIVESYLGRPWKKFSTTVIINSEIGDVIRPEGWKIWDGESFHKSCRYVEYNNRGPGAITNRRVNWVKIARSAAEVNDFTVANWLGPINWIQEANVPVTLGL
Protein: Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3) (P21266)
Organism: Homo sapiens (Human)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
Subcellular location: Cytoplasm.
Interaction partners:
- Glutathione S-transferase Mu 2
- Glutathione S-transferase Mu 4
- Epoxide hydrolase 1
- Glutathione S-transferase Mu 5
- Cytochrome P450 1A1
- Cytochrome P450 2E1
- Cytochrome P450 1B1
- Peroxiredoxin-6
- Cytochrome P450 1A2
- Cytochrome P450 2C9
Sequence:
MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLDFPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCYSSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLDEFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC
Protein: DNA beta-glucosyltransferase (BGT) (Beta-GT) (EC 2.4.1.27) (P04547)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Catalyzes the transfer of glucose from uridine diphosphoglucose to 5-hydroxymethyl cytosine of T4 DNA to yield glucosyl 5-hydroxymethyl cytosine (glc-HMC). This DNA process seems to occur immediately after DNA synthesis since the DNA alpha-glucosyltransferase interacts with the clamp protein gp45. The glc-HMC modification protects the phage genome against its own nucleases and the host restriction endonuclease system. The glc-HMC modification also protects against the host CRISPR-Cas9 defense system.
Interaction partners:
Sequence:
MKIAIINMGNNVINFKTVPSSETIYLFKVISEMGLNVDIISLKNGVYTKSFDEVDVNDYDRLIVVNSSINFFGGKPNLAILSAQKFMAKYKSKIYYLFTDIRLPFSQSWPNVKNRPWAYLYTEEELLIKSPIKVISQGINLDIAKAAHKKVDNVIEFEYFPIEQYKIHMNDFQLSKPTKKTLDVIYGGSFRSGQRESKMVEFLFDTGLNIEFFGNAREKQFKNPKYPWTKAPVFTGKIPMNMVSEKNSQAIAALIIGDKNYNDNFITLRVWETMASDAVMLIDEEFDTKHRIINDARFYVNNRAELIDRVNELKHSDVLRKEMLSIQHDILNKTRAKKAEWQDAFKKAIDL
Protein: Myocyte-specific enhancer factor 2B (O55087)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Calcineurin-binding protein cabin-1
- Nuclear factor of activated T-cells, cytoplasmic 3
- Nuclear factor of activated T-cells, cytoplasmic 2
- Nuclear factor of activated T-cells, cytoplasmic 1
- Nuclear factor of activated T-cells, cytoplasmic 4
- Homeobox protein Nkx-2.5
- Myocyte-specific enhancer factor 2A
- Myogenin
- Histone deacetylase 9
- Myocyte-specific enhancer factor 2D
Sequence:
MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCDIALIIFNSAQRLFQYASSDMDRVLLKYTEYSEPHESRTNADILQTLKRRGVGLDGPELDMEEGPEGPGEKLLRTLGGDRGSASPRPRIYPVAPAMSVSELSYRVPPATPGCDPGGLGEVPSVHSRPAYFRPPGLGHPIFSPSHLASKTPPPLYLATDGRRPDLPPGLVGARGGLGTSRSLYSGLQSPGAPGPALGSFAFLPSGSTDCSPGDAAQGPLQPSPWPPTRDAVDPARPVARSLCKEGPPSRGASPPTPPVSIKSERLSPVTGTSGDFPRSFPYPLLLARPLAEPLRPSASLHRLTPDSWPR
Protein: Protein kinase D, isoform H (EC 2.7.11.1, EC 2.7.11.17) (Protein kinase D, isoform I) (A0A0B4KGF0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MEGPEVTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNVLHIINSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQGLKCDGCGQNYHKRCVVKIPNNCNRSNDATSRRSFTLQAPRSPSGSSQQSLVSTEDSTGRNDSSSSLVKRMSDLMNDIIKH
Protein: GEO11133p1 (IP20249p) (IP20549p) (SRA stem-loop interacting RNA binding protein 2) (Q9VHP3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- EG:BACN32G11.3 protein
- Leucine-rich PPR motif-containing protein
- LD31543p
Sequence:
MSSGFVRSSYKLFVGNLPWTIGSKELRTYFSKYGHVANAEVVFDRQLGLSKHYGFVVFSQRDAFNSASNQNTHFLDGRVLTVQRANESPQS
Protein: Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) (Q04736)
Organism: Mus musculus (Mouse)
Function: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis (By similarity). Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity.
Subcellular location: Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell junction {ECO:0000250|UniProtKB:Q28923}. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. Localized to small puncta throughout the cytoplasm and cell membrane when in the presence of SNAIL1 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q28923}.
Interaction partners:
- Tyrosine-protein kinase Fyn
- SHC-transforming protein 1
- Catenin delta-1
- Tyrosine-protein kinase Fer
- Epidermal growth factor receptor
- Tyrosine-protein phosphatase non-receptor type 11
- GRB2-related adaptor protein 2
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Proto-oncogene tyrosine-protein kinase Src
Sequence:
MGCIKSKENKSPAIKYTPENLTEPVSPSASHYGVEHATVAPTSSTKGASVNFNSLSMTPFGGSSGVTPFGGASSSFSVVSSSYPTGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNYVVPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
Protein: Heparin-binding hemagglutinin (Adhesin) (P9WIP9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Required for extrapulmonary dissemination. Mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at the surface of these cells; binds heparin, dextran sulfate, fucoidan and chondroitin sulfate. Promotes hemagglutination of erythrocytes of certain host species. Induces mycobacterial aggregation.
Subcellular location: Cell surface.
Interaction partners:
- Chaperone protein DnaK
- Uncharacterized protein Rv0477
- Diacylglycerol acyltransferase/mycolyltransferase Ag85B
- Chaperonin GroEL 1
- Uncharacterized protein Rv0476
- Possible conserved secreted protein
- Conserved protein
- Probable conserved transmembrane protein
- Uncharacterized protein Rv1109c
- Peroxynitrite isomerase 2
Sequence:
MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKLQEDLPEQLTELREKFTAEELRKAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPKKAAPAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK
Protein: SERTA domain-containing protein 3 (Replication protein-binding trans-activator) (RPA-binding trans-activator) (Q9UJW9)
Organism: Homo sapiens (Human)
Function: Strong transcriptional coactivator.
Subcellular location: Nucleus {ECO:0000269|PubMed:10982866}.
Interaction partners:
- Replication protein A 32 kDa subunit
- CST complex subunit STN1
Sequence:
MVGGLKRKHSDLEEEEERWEWSPAGLQSYQQALLRISLDKVQRSLGPRAPSLRRHVLIHNTLQQLQAALRLAPAPALPPEPLFLGEEDFSLSATIGSILRELDTSMDGTEPPQNPVTPLGLQNEVPPQPDPVFLEALSSRYLGDSGLDDFFLDIDTSAVEKEPARAPPEPPHNLFCAPGSWEWNELDHIMEIILGS
Protein: FinTRIM family, member 82 (Si:dkey-252h13.6) (Q08CC1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAEQMSPDYFNCPLCTELLRDPVAIPCGHSFCMDCISGYWNEADYTGIYICPQCRITFTQRPVLRPNATLTKVAEKIKKTGLNLTPPSNGSCAGPGDVPCDFCTGQKLKAVKSCLNCLASYCEKHLKPHYESATFKRHKLVDELGNLDRKICPQHQKSLELFCRTDQMCICAICTVSEHKGHDIVSAEAERGEKQKLLGVSQAEIKQKCQQRTKELEELKTAVDSLKGSAQRAMAESKKMFDEMITSIERMRSEVTKMININERAAFSQAEGLMERLEQEIDELKKKETGLKQLYSTEDHIHFLQNFNYLCTPTDDGFIPRVTLNPDFSFSSARKAVAEIKERLEELGRDELRKISKSVNEVPVYTVENRTKEKTARAKEIHTVDSSPPVEPKTRSEFLKYYCQLKLDSHTAHKELYLSEGGKKVIRTRDLQPYSDNQDRFDSFARVLCREGLSGGRYYWEVEWSGEFSIGVAYRGISRKGKGSLCLLGYNDKSWSLLCSDTGYSAWHNRADKAVSGPHSSRIGVFLDHSAGVLSFYSIGDTMTRLYRFETTFTEPLYPGFGVGTSVKICQLK
Protein: DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC 2.7.7.6) (RNA polymerase subunit beta') (Transcriptase subunit beta') (P37871)
Organism: Bacillus subtilis (strain 168)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit omega
- DNA-directed RNA polymerase subunit alpha
- RNA polymerase sigma factor SigA
- Small ribosomal subunit protein uS7
- Elongation factor G
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL11
Sequence:
MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVSHIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLDKYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRNSGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIERVQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADFDGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAGAVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLVFNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKIIAEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDNVMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASNFTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPETGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVEVGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATITEIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSIDPKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDVLPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVLTDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A1P8ASI5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MLRLRRSLFLLLTVWFLCCSGLVHVMVRAQNRTRPTTHPDDARALNSIFAAWKIRAPREWNISGELCSGVAIDASVLDSNHAYNPLIKCDCSFQNSTICRINNIKVYAIDVVGPIPPELWTLTYLTNLNLGQNYLTGSLSPAIGNLTRMQWMTFGINALSGPIPKEIGLLTDLRLLGISSNNFSGSLPAEIGSCTKLQQMYIDSSGLSGGIPLSFANFVELEVAWIMDVELTGRIPDFIGFWTKLTTLRILGTGLSGPIPSSFSNLIALTELRLGDISNGSSSLDFIKDMKSLSVLVLRNNNLTGTIPSTIGGYTSLQQVDLSFNKLHGPIPASLFNLSRLTHLFLGNNTLNGSLPTLKGQSLSNLDVSYNDLSGSLPSWVSLPDLKLNLVANNFTLEGLDNRVLSGLHCLQKNFPCNRGEGIYYNFSINCGGPEIRSVSGALFEKEDADLGPASFVVSAAKRWAASSVGNFAGSSNNIYIATSLAQFINTMDSELFQSARLSASSLRYYGLGLENGGYTVTLQFAEVQIEGSNSWKGIGRRRFNIYVQGRLVEKDFDIRRTAGGSSVRAVQREYKTNVSENHLEVHLFWAGKGTCCIPIQGAYGPLIAAVSATPDFTPTVANRPPSKGKSRTGTIVGVIVGVGLLSIFAGVVILVIRKRRKPYTDDEEILSMDVKPYTFTYSELKNATQDFDLSNKLGEGGFGAVYKGNLNDGREVAVKQLSIGSRQGKGQFVAEIIAISSVLHRNLVKLYGCCFEGDHRLLVYEYLPNGSLDQALFGDKSLHLDWSTRYEICLGVARGLVYLHEEASVRIIHRDVKASNILLDSELVPKVSDFGLAKLYDDKKTHISTRVAGTIGYLAPEYAMRGHLTEKTDVYAFGVVALELVSGRKNSDENLEEGKKYLLEWAWNLHEKNRDVELIDDELSEYNMEEVKRMIGIALLCTQSSYALRPPMSRVVAMLSGDAEVNDATSKPGYLTDCTFDDTTSSSFSNFQTKDTSFSTSFIAPGPEMPLRDGESKPMVGFKIKEGR
Protein: Chaperone protein DnaJ (Q9U0J2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Endoplasmic reticulum chaperone GRP170
- Heat shock protein 70
- Thioredoxin-like protein
- Endoplasmic reticulum chaperone BIP
Sequence:
MLALRILRRKVCSEHFLFERSFFTQSIKGKNGCLVTRYDKNKLLFYYKRNINTSRKCLNQDPYTVLGLSRNATTNDIKKQFRLLAKKYHPDINPSPDAKQKMASITAAYELLSDPKKKEFYDKTGMTDDSNYQNHSSNFEGAFSGFGDASFMFTDFAEMFTNMAGGNKNTSTRGEDIQSEITLKFMEAIKGCEKNIRLNVKVSCNNCNGSGKKPGTNLTICKVCNGSGIQRMERGPIIIGVPCRNCSGNGQIINNPCKHCSGSGVKFQTKNITLDIPPGIKKGMQMRIPNQGHCGYRGGKSGHLFVTINIEPHKIFKWVDDNIYVDVPLTIKQCLLGGLVTVPTLNGDMDLLIKPKTYPNSEKILKGKGPCKVDSHNNGDLIIKFSLKIPEKLTPRQVELIEEFNTIELNLPNPQTNVKQKKNIYETKGNINENIFSMNNTYNNMKGPEGETSNTQAKSMKNQNWNNEKSVNNKGTISKDEKKLNMKNNHINEKSNLKNSSHMDTNKNEENMSDDEKKKIKKIIPEPPMPHTHKIVNNLESKNSCNIPIPPPPPKSSSKPISENQNISNREHNGVTNNSAKLDNNINMNYSCDPYKNVTQNDLNNNDNIKNKIYKDNTNISNHHIFKNDNINQQQFHCADNSSENNNESDMNTTSTFSFAKKWISDKLKPKN
Protein: ER degradation-enhancing alpha-mannosidase-like protein 2 (Q8BJT9)
Organism: Mus musculus (Mouse)
Function: Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (By similarity). Seems to recognize and bind to exposed hydrophobic regions in target proteins.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15579471}.
Interaction partners:
- ER degradation-enhancing alpha-mannosidase-like protein 3
- ER degradation-enhancing alpha-mannosidase-like protein 1
- Thioredoxin domain-containing protein 11
- Protein OS-9
- Alpha-mannosidase 2C1
- Protein sel-1 homolog 1
- UDP-glucose:glycoprotein glucosyltransferase 1
- Short transient receptor potential channel 4-associated protein
Sequence:
MPFRLLIPLGLVCVLLPLHHGAPGPDGTAPDPAHYRERVKAMFYHAYDSYLENAFPYDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNTSEFQRVVEVLQDNVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTHFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFHPNNFIHNNGSTFDSVMTPHGECILGAGGYIFNTEAHPIDPAALHCCRRLKEEQWEVEDLIKEFYSLKQSRPKRAQRKTVRSGPWEPQSGPATLSSPANQPREKQPAQQRTPLLSCPSQPFTSKLALLGQVFLDSS
Protein: RhoA (O35791)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
VGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRG
Protein: Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (A52) (P47963)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}.
Interaction partners:
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein eL30
- Small ribosomal subunit protein eS8
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein eS21
Sequence:
MAPSRNGMILKPHFHKDWQQRVDTWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPIRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVEKKK
Protein: Pygopus 2 (Q3V113)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKSPEKKRRKSNTQGPAYSHLTEFAPPPTPMVDHLVASNPFEDDFGAPKVGGAGPPFLGSPVPFGGFRVQGGMAGQVPPGYGTGGGGGPQPLRRQPPPFPPNPMGPAFNMPPQGPGYPPPGNMNFPSQPFNQSLGQNFSPPGGQVMPGPVGGFGPMISPTMGQPPRGELGPPPLPQRFTQPGAPFGPSLQRPGQGLPSLPPNTSPFPGPDPGFPGPGGEDGGKPLNPPAPTAFPQEPHSGSPAAAVNGNQPSFPPSSSGRGGGTPDANSLAPPGKAGGGSGPQPPPGLVYPCGACRSEVNDDQDAILCEASCQKWFHRECTGMTESAYGLLTTEASAVWACDLCLKTKEIQSVYIREGMGQLVAANDG