wanglab/gogpt-training-data huggingface dataset:
Protein: BK channel (H7BRC9)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGEIYSPSQSKGFNQPYGYPMNCNLSRVFMEMTEEDRKCLEERKYWCFLLSSITTFCASMILVVIWRVVTHLCCQRREKEFVEPIPAPEAVQINMNGSKHAPSETDPFLKQQEEKHLGWMTEAKDWAGELISGQSLTGRFLVLLVFILSIGSLIIYFYDASFQNFQVETCIPWQDSPSQQIDLGFNIFFLVYFFIRFIAASDKVWFLLEMYSWIDFFTIPPSFVAIYLQRNWLGFRFLRALRLMTVPDILQYLNILKTSSSIRLTQLVTIFVAVCLTGAGLVHLLENSGDFFKGFINPHRITYADSVYFVLVTMSTVGYGDIYCTTLCGRLFMIFFILFGLAMFASYVPEIADLIGNRQKYGGEYKGEHGKKHIVVCGHITYDSVSHFLQDFLHEDRDDVDVEVVFLHRVVPDLELEGLFKRHFTKVEFFTGTVMDSLDLSRVKIGDADACLVLANKYSTNPDAEDAANIMRVISIKNYSSDIRVIVQLMQYHNKAYLLNIPSWDWKRGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSPHTPLWLNDYLRGAGMEMYTESLSPSFANMSFPEAANLLFNRLGLLLLAIELKDEENKECNIAINPGPHIVIQPQTQGFFIAQSADEVKRAFFWCKQCHDDIKDVSLIKKCKCKNLALFRRNTKHSTAAREKNAKISDYSDFDALFYQNDARATDVLQQFQPQAPAGPMGHLGQQVQLRMINQQSSTSDTHLNTKSLRFAYEIKKLMPSSGGRRNSMSIPPDGRGVDFSKDFEQQFQDMKYDSTGMFHWCPSRNLEDCVLERHQAAMTVLNGHVVVCLFADQDSPLIGLRNFIMPLRSSNFHYHELKHVVIVGDLEYLRKEWKTLYNLPKISILNGSPLSRADLRAVNINLCDMCVIISARVPNTEDTTLADKEAILASLNIKAMQFDDTLGFFPMRHQTGDRSPLGSPISMQKKGAKFGTNVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRGGYSTPETLSNRDRCRIAQISLQDNPYDGVVHNTTYGAMFTIALRRYGQLCIGLYRLHDQDNPDSMKRYVITNPPAELRIKNTDYVYVLEQFDPGLEYEPGKRHF
Protein: Protein ecdysoneless homolog (Suppressor of GCR two) (sgt1) (Q9US49)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the regulation of carbohydrate metabolism. May act as a transcription factor.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- A1 cistron-splicing factor aar2
- Pre-mRNA-splicing factor brr2
- Probable methionine--tRNA ligase, cytoplasmic
- Glucose-insensitive transcription protein 7
- Pre-mRNA-splicing factor spp42
- Adenylate cyclase activation protein git1
Sequence:
MSNLGNNITERIESDCISQNECRIDVYFSEKEKESTEASINMFLAELERLQLEYGKEHIWQNEELNLQRVEYQGKDCILGITNFGDCIDDEWYIVWLLREASKAVKSAFVRIIDEDGEFLLIEAALSLPKWIDEDNSDYRVWIHNGEVIILRPEDEFLKKMNRCPPLTREQAIFQISSGSNLYTSREVNDSISQRLKKFPKAANVKLRAICTVPRKIVHVLQKNKNLISSAVNAFYYRDPIDENYCDRMSKFNQNDLVTTTITFTPLLYAQLYQQRCKTFRPFHLPSDVHSLDYERAILGMKLSCGFEILYNSKENVEKRTEIDEYLQIQPLPTDEDIKKIPLIEDDTSFMNVNPDELEELLEKKLNSFCDDFGDDERSGFDNTDHDNTLVGEEEMVPGNHGGKSINEEITKNKQKQNFNESDLKNMASRIETFINDEASNNHREDFYGVKNSDTDTDSDSLADSDDEIFLNRNQGIDEVEFDETKFYDLLKGKDGKYQNQDVDEFSSGNEDEMDIPGDANMEEYMRAMDEELYGGLRGRDEGLEGIDDKDIDLNLMKNIIEGIEANPDLYGGPISTLLNSLKIQIPREK
Protein: F25A4.19 protein (Homeodomain-like superfamily protein) (MYB transcription factor) (Putative MYB family transcription factor; 86049-87165) (Putative myb-related transcription activator) (Q9S7N6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Lysine-specific demethylase JMJ21
- Protein DETOXIFICATION 37
- Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 8
- At1g26580
- Protein REVEILLE 7-like
- Kelch repeat-containing protein At3g27220
- Probable WRKY transcription factor 67
- Protein REVEILLE 5
- Receptor-like protein 54
- Telomere repeat-binding factor 3
Sequence:
MADGSTSSSESTTACAGSGTRREIMLFGVRVVLDPMRKCVSLNNLSDYEQTAETPKIDGEDRDEQDMNKTPAGYASADEALPMSSSNGKIERKRGVPWTEEEHKLFLLGLQRVGKGDWKGISRNFVKTRTSTQVASHAQKYFLRRSNLNRRRRRSSLFDMTTDTVIPMEEDHQVLIQENTSQSSSPVPEINNFSIHPVMQVFPEFPVPTGNQSYGQLTSSNLINLVPLTFQSSPAPLSLNLSLASSNLNEPSPSMHPAFNTIGVA
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit) (E7EWP0)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004298}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004298}; Matrix side {ECO:0000256|ARBA:ARBA00004298}.
Interaction partners:
Sequence:
MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPGNHHSAVFMILTTLFLIFYIALTGIPVAIFITLVNVFIGQAELAEIPEGYVPEHWEYYKHPISRWIARNFYDSPEKIYERTMAVLQIEAEKAELRVKELEVRKLMHVRGDGPWYYYETIDKELIDHSPKATPDN
Protein: LD27322p (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform B) (Q9VE12)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Early endosome {ECO:0000256|ARBA:ARBA00004412}. Late endosome {ECO:0000256|ARBA:ARBA00004603}.
Interaction partners:
- GH12955p
Sequence:
MAQVAFLDNLLREYLVFRGFSSTLKALDLEQRTEKDQHFRAERILEQFNNAVQASDLQALRSLWFHLDNNIFSKLEHTYAVAVKKLENSLLKYYLVTAYSSNRPEKVSEFFNKLAGDLQQQSEWKDWFYFPFCKNAEESPTFALFFTKQWQDTLLLSLRNFLTTVYQCLPQPTFVRAEQEAAHMQRLSEDNAGLRTRVLNLQQELNQMTQQQSGTAAASGSSLGGGVDNGARRRSVYRQQQSLSDILPFDISPPGHIVDDFCIIASEANSVSQASDAQARSLKQLIRNIGSGSSPVMGRKDQTASSLGEKSTKRRSGSLGRSWI
Protein: BTB/POZ domain-containing protein 2 (Q9BX70)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12878161}. Note=Localizes to punctate or elongated cytoplasmic bodies. {ECO:0000269|PubMed:12878161}.
Interaction partners:
- Tripartite motif-containing protein 5
- DNA topoisomerase 1
- Cullin-3
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 8
- BTB/POZ domain-containing protein 1
Sequence:
MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPPAPPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT
Protein: MADS-box transcription factor 18 (FDRMADS7) (MADS-box protein 2) (MADS-box protein 28) (OsMADS18) (OsMADS2) (OsMADS28) (Q0D4T4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor that may promote floral transition phase and differentiation program of the vegetative shoot.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGRGPVQLRRIENKINRQVTFSKRRNGLLKKAHEISVLCDADVALIVFSTKGKLYEFSSHSSMEGILERYQRYSFDERAVLEPNTEDQENWGDEYGILKSKLDALQKSQRQLLGEQLDTLTIKELQQLEHQLEYSLKHIRSKKNQLLFESISELQKKEKSLKNQNNVLQKLMETEKEKNNAIINTNREEQNGATPSTSSPTPVTAPDPIPTTNNSQSQPRGSGESEAQPSPAQAGNSKLPPWMLRTSHT
Protein: Probable 2-dehydropantoate 2-reductase (EC 1.1.1.169) (Ketopantoate reductase) (KPA reductase) (KPR) (Q9HDU6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Interaction partners:
- Pantoate--beta-alanine ligase
- Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase
- Meiotically up-regulated gene 72 protein
- Uncharacterized protein PB2B2.11
- Cytochrome b translation regulator cbp7
- Diphosphomevalonate decarboxylase
- UPF0643 protein PB2B2.08
Sequence:
MNNTIYILGAGSIGSLLAYELASLKSINNRVILLLRDKSRVNSFKDKNSTLKIDRLFEENVPHLCCQVTASEPSQLNVQSIENMIVTTKAGQTENALSKYLPYLSKNSNILFVQNGMGAVENVCGKLWPEEQNKPSIYQGVISHGCFQTAPFHFSHAGLGDLKISKVPKNPKKILPDEAAETPCEMIKSLGKSELLRLRYMNYPELLVNQCEKLVINACINPTTATLDCVNGELYNDESAKELFRCIIKECVDIFFKCIPLFKNNEEAEKILNVNRLLDRVMFVGTKVNGANSSSTRQDCLLLRETEIDAINGYVVKLAENNGFQATVNKTMMLLTKSRLGLNRCRAHAR
Protein: Plasma membrane ATPase (EC 7.1.2.1) (Proton pump) (Q7M290)
Organism: Avena sativa (Oat)
Function: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16665938}; Multi-pass membrane protein {ECO:0000269|PubMed:16665938}.
Interaction partners:
Sequence:
WGEQEASILVPGDIVSIKLGDIVPADARIDQSGLTGESLPVTKNPGDEVFSGSTCKTGTLTLNKGIVGMTGDGVNDAPALKTLHGLQAPESTSLNLPNDKELSEIAEQAK
Protein: Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) (Proteasome subunit alpha-2) (alpha-2) (P25787)
Organism: Homo sapiens (Human)
Function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951). Colocalizes with TRIM5 in cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:P49722, ECO:0000269|PubMed:34711951}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 7
- Proteasome subunit beta type-1
- 26S proteasome non-ATPase regulatory subunit 12
- Proteasome subunit alpha type-6
- 26S proteasome non-ATPase regulatory subunit 13
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-4
- 26S proteasome non-ATPase regulatory subunit 2
- 26S proteasome non-ATPase regulatory subunit 1
- Proteasome subunit beta type-8
Sequence:
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
Protein: Alcohol dehydrogenase 1 (EC 1.1.1.1) (P48814)
Organism: Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Interaction partners:
Sequence:
MSLAGKNVVFVGGLGFIAYEACKYLMNNDLASLFVFDVLDKPEAIKALQEINPKTKVYYTKFDITNKESIKQSLADVISKVQHIDALINGAGILTDPNVELTMNINLIGLINTTLEALPLMDKNKHGRGGVIVNIASVLGLEPCPPAAVYCASKFGVVGFSRSLGDPFYYEHTGVAVVTFCPGLTDTPLKNNIGSKYTFDYSKEIGEKLNSSKTQKPEVCGAHLAQAIELMDNGAIYISNQGTLTKVKPSVYWEPTY
Protein: CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) (Phosphatidylserine synthase) (O94584)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Phosphatidylserine synthase involved in the regulation of processes such as cell morphology, cytokinesis, actin cytoskeleton, and cell wall remodeling and integrity. Also plays a role in the physiological adaptations required for stationary-phase survival.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=During log-phase growth, concentrates at the cell and nuclear peripheries as well endoplasmic reticulum membranes, while in stationary-phase cells, is redistributed to unusual cytoplasmic structures of unknown origin.
Interaction partners:
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Phosphatidylserine decarboxylase proenzyme 3
- Putative phosphatidate cytidylyltransferase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- Phosphatidylserine decarboxylase proenzyme 2, mitochondrial
- Tryptophan synthase
- Probable phosphoserine phosphatase
- Lysophospholipid acyltransferase
Sequence:
MVRSRVSPGLKLQSDASNQSNDKENKLLAYVNDNRHFSLIRALHLADLITLMNGFCGVMSIFSSLRYCLSGQQSAFHLWNAMYFMPFALFFDFLDGKVARWRGKSSLMGQELDSLADLISFGVSPAVFAFCCGFQTFLDTVILSLFVLCGLTRLARFNVSVNSIPKDGSGKSQFFEGTPIPTTLSLVTVCGVCILKGKTHENLPWGEWCGNTPFAFHPLVVLFVLSGIAMTSKKLKVPKI
Protein: Zinc finger protein GLIS1 (GLI-similar 1) (Gli homologous protein 1) (GliH1) (Q8K1M4)
Organism: Mus musculus (Mouse)
Function: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'. By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells. Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast.
Subcellular location: Nucleus {ECO:0000269|PubMed:12042312}.
Interaction partners:
- Protein L-Myc
Sequence:
MHCEVAEALSDKRPKEAPGAPGQGRGPVSLGAHMAFRIAVSGGGCGDGNPLDLLPRLPVPPPRAHDLLRPRSPRDYGVSKTGSGKVNGSYGHSSEKSLLDLDLAEGPSPSCHQGLFLPAGTPPPRGHPPVCEKLLHFPHPNRSPRPQATFVNGSLPAAQHIKQEALPDYQAMVSAHTPLPTHCRAPSSMGLPSDLDFPDRGLTNPAPSCYLLGNEPISDLGPQPEAHLPEGSLKRCCLLGLPPTSSASSSPCASSDINPVIHSSQTALVSCVNGLRSPPLPGDLGGPPKRSRPGPASSDGQEGSLQLEACRKSGFLKQEPMDEFSELFAPHHQGLPPPYPLPQLPTGPGLGGLGLGLAGRMVAGRQACRWVDCCAAYEQQEELVRHIEKSHIDQRKGEDFTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHTGADPEADVLSECLSLQQLQASTLLPASRGKGSQTLSQELLPGVYPGSVTPQNGLASGILSPSHDVPSRHHPLEVPTGSHHHLSPLPTAESTRDGLGPSLLSPMVSPLKGLGPPPLPPASQSQSPGGQSFSTVPSKPTYPSFQSPPPLPSPQGYQGSFHSIQNCFPYADCYRATEPAASRDGLVGDAHGFNPLRPSTYSSLSTPLSAPGYETLAETPCPPALQPQPAEDLVPSGPEDCGFFPNGAFDHCLSHIPSIYTDT
Protein: Ermin (Juxtanodin) (JN) (Q8TAM6)
Organism: Homo sapiens (Human)
Function: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Opalin
- Myelin-associated oligodendrocyte basic protein
- Myelin basic protein
- Hyaluronan and proteoglycan link protein 2
Sequence:
MTDVPATFTQAECNGDKPPENGQQTITKISEELTDVDSPLPHYRVEPSLEGALTKGSQEERRKLQGNMLLNSSMEDKMLKENPEEKLFIVHKAITDLSLQETSADEMTFREGHQWEKIPLSGSNQEIRRQKERITEQPLKEEEDEDRKNKGHQAAEIEWLGFRKPSQADMLHSKHDEEQKVWDEEIDDDDDDNCNNDEDEVRVIEFKKKHEEVSQFKEEGDASEDSPLSSASSQAVTPDEQPTLGKKSDISRNAYSRYNTISYRKIRKGNTKQRIDEFESMMHL
Protein: SH3 domain-containing protein (Q21430)
Organism: Caenorhabditis elegans
Interaction partners:
- Serine/threonine-protein kinase pak-1
- Arf-GAP domain-containing protein
- Paralyzed arrest at two-fold protein 6
- Serine/threonine-protein kinase max-2
- Cell division control protein 42 homolog
- Protein shank
- DH domain-containing protein
- Ras-related protein ced-10
- Protein ECT2
- E3 ubiquitin-protein ligase CBL
Sequence:
MEPGSGSPLSARAKFQFEGSNNDELSFDKDDIITITQQQEGGWWEGTHEGVTGWFPCAYVTLITEKDKLQRSRSVPNATAKEVVSVGAQPDYRDLVLKSYIESEKEYMQSLLKTLQSLLIPIGASKILTAPEYCTLVGNFEVIYTLKRDLFEQLEREQNEELPKMRVGGMFMNAALELRTALMSYADNHPDAVEVLKKKQKELEKVVKSQDREYKELVLGLSEPLRHVERYYNLLQELERIVPANHPDRGDLQRGSAVFRETKDLCETLRKQKEAQLDFLFVSKVDKVVSASERGSILYVGVANVEYKKADAVDRFVALFTKYIMFFEVTKDMTYDIKEKFTVSGFIVRKKEATEISFDRPNTGEFTLTMVSTGGEVERFLVALAKAENVAIITPTTTILRRPSKNANDTMNQSQTQGAETPLVAKPPLHPPGNSDQQYSMMNKRKSSKNFDDSLNLGNMKFDHELGMVLPEGFELPTSSRNSRNTADNLQFSQFPSFFLSGNAGKRGDRNIRLRKDAARDEEIEFETLRILEGYCVETGGGQSDFHANESYQQPHLIVAEDEKILMEEMIGDEVVLQEKSIVDAVYAIKDQLSFLQTEFQKLAKVVESEQKARRRLEHNLPKMSGVISPDGSSSTPRKEINSFDL
Protein: Interleukin-13 (IL-13) (Q95J68)
Organism: Sus scrofa (Pig)
Function: Cytokine that plays important roles in allergic inflammation and immune response to parasite infection. Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6. Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Interleukin-4 receptor subunit alpha
- Interleukin-13 receptor subunit alpha-2
- Interleukin-13 receptor subunit alpha-1
- Interleukin-5
- Interleukin-4
- Interferon gamma
- Interleukin-10
- Signal transducer and activator of transcription
- Interleukin-17A
- Granulocyte-macrophage colony-stimulating factor
Sequence:
MALWLTLVIALTCFGGLASPGPVPPHSTALKELIEELVNITQNQKTPLCNGSMVWSVNLTTSMQYCAALESLINISDCSAIQKTQRMLSALCSHKPPSEQVPGKHIRDTKIEVAQFVKDLLKHLRMIFRHG
Protein: Zinc finger protein 319 (Q9P2F9)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MSESWQQPPQTQPQQPQPPQPQHHAEPPPALAEHTLPPGTAENPLGCAVYGILLQPDPGLQPPQHAPLQAAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHSSHSGLVKCSICEKTYKPAEAAEPATTAAPSLPAAPAPSTVTPAEQADKPYSCPICQKPFKHLSELSRHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRHMYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEEPFKCGLCEKGFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPGAAERPFKCPVCNKAYKRASALQKHQLAHCAAAEKPLRCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCEKRFKYASDLQRHRRVHTGEKPYKCPNCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSAAAAAAEGAYQVAACLP
Protein: vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.17.4.4) (A0A0S2Z5X7)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
Sequence:
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRLPADTLGLCPDAAELPGVSRWFCLPGLDPVLRAL
Protein: Amyloid beta A4-like protein 1 (Q1P9T9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
SGLLIMGAGGGSLIVLSLLLLRKKKPYGTISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
Protein: Retinoic acid receptor beta (Nuclear receptor subfamily 1 group B member 2) (A0A8I6AIB6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MYPCTSAKDRQPSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPNSSGNTAEHSPSVSPSSVETSGVSQSPLLQ
Protein: Homeobox A11 (H0YIA6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
XIRFKEAAAVENHVKLGYCGEPKVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAGVPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDYPGDKSAEKGPPAATATSAAAAAAATGAPATSSSDSGGGGGCRETAAAAEEKERRRRPESSSSPESSSGHTEDKAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSANPLL
Protein: Proliferating cell nuclear antigen (B9EMQ6)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU000641}.
Interaction partners:
Sequence:
MFEARLVQGSILKKVLEALKDLITEACWDVSSSGISLQSMDSSHVSLVQLTLRSDGFDSYRCDRNLAMGVNLSSMSKILKCAGNEDIITLRAEDNADTLALVFETLNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVRMPSGEFARICRDLSQIGDAVMISCAKDGVKFSATGELGTGNVKLSQTSNVDKEEEAVSIEMNEPVQLIFALNYLNFFTKATPLSKTVILSMSADIPLVVEYKIADMDHVKYYLAPKIDEEAS
Protein: Eb1, isoform F (FI12926p) (A1Z6P3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Restin homolog
- Short stop, isoform H
- Protein mini spindles
- Protein claret segregational
Sequence:
MAVNVYSTNVTSENLSRHDMLAWVNDCLQSQFSKIEELCTGAAYCQFMDMLFPNSVPVKRVKFRTNLEHEYIQNFKILQAGFKKMSVDKIIPVDKLIKGRFQDNFEFLQWFKKFFDANYDGREYDPVAQRGGVKLGNGNGHGSNGGSGVGSSNNDLHLMHRRPLQAPASGGRMPARVIASTAVSKVLPRTNNAAPASRINACANSTGTVKKNDVSNSVNNQQIEEMSNQVMDMRINLEGLEKERDFYFSKLRDIEILCQEADDAEAHPIIQKILDILYATEDGFAPPDDAPPEDEEY
Protein: Agmatine coumaroyltransferase (EC 2.3.1.64) (Q9FNP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biosynthesis of hydroxycinnamic acid amides, which play a role in defense against pathogens. Agmatine is the preferred acyl acceptor, lower activity is observed towards putrescine. The preferred acyl donor is p-coumaroyl-CoA, lower activity is seen towards feruloyl-CoA.
Interaction partners:
- Probable polyamine oxidase 4
- Spermine synthase
- Spermidine synthase 1
- Agmatine deiminase
- Arginine decarboxylase 1, chloroplastic
- N-carbamoylputrescine amidase
- Polyamine oxidase 3
- Polyamine oxidase 2
- Arginine decarboxylase 2
- Spermidine synthase 2
Sequence:
MALKVIKISRVSPATASVDPLIVPLSFFDLQWLKLNPTEQVFFYKLTESSSSRDVFYSSILPKLERSLSLILTHFRLFTGHLKWDSQDPKPHLVVLSGDTLSLTVAETDADFSRISGRGLRPELELRPLIPELPIYSDSGAVVSLQVTLFPKQGFCIGTTAHHVVLDGKTAEKFNKAWAHTCKHGTIPKILPTVLDRSVVNVPAGLEQKMLELLPYLTEDDKENGRTLKLPPVKEINAKDNVLRITIEISPENIEKLKERAKKESTRAELHLSTFVVTFAHVWTCMVKARSGDPNRPVRFMYAADFRNRLEPPVPVTYFGTCVLAMDFYKYKAKEFMGEDGFVNTVEILSDSVKRLASQGVESTWKVYEEGTKTMKWGTQLLVVNGSNQIGMYETDFGWGRPIHTETMSIYKNDEFSMSKRRDGIGGVEIGISLKKLEMDTFLSLFYKWIGN
Protein: Mini-chromosome maintenance complex-binding protein (A0A0S2Z5P5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPCGEDWLSHPLGIVQGFFAQNGVNPDWEKKVIEYFKEKLKENNAPKWVPSLNEVPLHYLKPNSFVKFRCMIQDMFDPEFYMGVYETVNQNTKAHVLHFGKYRDVAECGPQQELDLNSPRNTTLERQTFYCVPVPGESTWVKEAYVNANQARVSPSTSYTPSRHKRSYEDDDDMDLQPNKQKDQHAGARQAGSVGGLQWCGEPKRLETEASTGQQLNSLNLSSPFDLNFPLPGEKGPACLVKVYEDWDCFKVNDILELYGILSVDPVLSILNNDERDASALLDPMECTDTAEEQRVHSPPASLVPRIHVILAQKLQHINPLLPACLNKEESKTFVSSFMSELSPVRAELLGFLTHALLGDSLAAEYLILHLISTVYTRRDVLPLGKFTVNLSGCPRNSTFTEHLYRIIQHLVPASFRLQMTIENMNHLKFIPHKDYTANRLVSGLLQLPSNTSLVIDETLLEQGQLDTPGVHNVTALSNLITWQKVDYDFSYHQMEFPCNINVFITSEGRSLLPADCQIHLQPQLIPPNMEEYMNSLLSAVLPSVLNKFRIYLTLLRFLEYSISDEITKAVEDDFVEMRKNDPQSITADDLHQLLVVARCLSLSAGQTTLSRERWLRAKQLESLRRTRLQQQKCVNGNEL
Protein: Beta-glucuronidase (EC 3.2.1.31) (A1ZBH0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSLSIFSLVTGLYVLHFSIALILVNKEVPQTRGMLYPRESETREVRSLDGIWNFVRSDQANPTQGVRDEWYAKELSKSRPTIPMPVPASYNDITTDNLRDHVGTVWYDRKFFVPRSWSKDQRIWLRFGSVHYEAYVWINGQKVVKHEMGHLPFEAEVTDLLSYGAENRITVMCDNALIQTTVPQGRITEVPNDGGMTIVQSYTFDFFNYAGIHRSVHLYTTPRTFIEEVEVTTNLSKDATVGEVFYSVSVNGSAANEADNVLQIQANLYDKDGILVANATSDQKLGGKLQVNPVKPWWPYLMHSEPGYLYQLEIKLLATNDELLDVYRLKVGIRTLSWNSQQFLINGKPVYFRGFGRHEDSDIRGKGLDNALMVRDFNLLKWIGANAYRTSHYPYSEESMQFADEHGIMIIDECPSVDTENFSQELLGKHKSSLEQLIHRDRNHPSVVMWSIANEPRTGSVSADSYFELVANFTRSLDKTRPITAAIAVSNTQDKAGRSLDIISFNRYNAWYSNAGRLDMITQNVIDEAIAWNKRYNKPIIMSEYGADTLEGLHMQPAYVWSEEFQTEVFSRHFKAFDELRKKGWFIGEFVWNFADFKTAQSYTRVGGNKKGVFTRARQPKAAAHLLRKRYFALGRDLDQCSFPEDLFTYIADLIS