wanglab/gogpt-training-data huggingface dataset:
Protein: Small muscular protein (Stretch-responsive skeletal muscle protein) (Chisel protein) (Q9DC77)
Organism: Mus musculus (Mouse)
Function: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.
Interaction partners:
- Cysteine and glycine-rich protein 3
- Integrin beta-1-binding protein 2
- Myomesin 2
- Myozenin-2
- Creatine kinase S-type, mitochondrial
Sequence:
MSKQPISNVRAIQANINIPMGAFRPGAGQPPRRKESTPETEEGAPTTSEEKKPIPGMKKFPGPVVNLSEIQNVKSELKFVPKGEQ
Protein: LP04345p (Q960I9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASISKSRASSCSSRKRLHLQPGSLLCVIVFCLLASCSAQPIESTSLPAEVDDVEGTTILPIQLEESSPTPEPIIKNETATALPVVELKVAESNPVDPVEATDNFVSVYGGNLEQDIKNDVNSEVEDAPSPVEPIIEEVQKVAEAELENHEIKLAVQSALEPKSLDAEEESKTIDEDRLENQDKAETVTDNIAVSSEQMESHIRPLPNVTSDLVSVILNEDKAITEQPITKTNLLALEQEHEKFEEIDESTTVPVYEEPKHQVTKKQGVEDPSTVEIPPEVSDEQHFDPSEEPQTVRDERNLEEHDDNQNEINENIIEGEEAPAKTSTTAGPLVTVEPTKSITEPNEEIEKKAEAEAKAEMEEQVEVNTPSVDATVVAADPDEAQDEVIVAETTVEAITEAAKIVVEEEPKEDVSVQQEHLKEQRVQTVSESNRQASPTEEPIKEVIFPKGDDESPVEGDSSESDEKPTERAIVDDDSSEEQNEDVVDEGKSSSDDSTATPLVSYPPHDAGQTFDSNSADEHSAQLSGATNYRSTLIIALCSGTAVIFIVASLVIFVVSFQRQHGTLDIEMQEQRLGKDIQEEDNVQMKLLDVDLSSPVILPMGNEETDECL
Protein: Kinesin motor domain-containing protein (Kinesin-like protein-18) (G5EBX0)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Calponin-homology
- Kinesin-like protein
- MEiotic SPindle
- Protein regulator of cytokinesis 1
- Uncharacterized protein C30G12.6
- Meiotic spindle formation protein mei-1
- Kinetochore protein ndc-80
- Kinesin-like protein klp-19
- Kinesin-like protein
- Kinetochore protein Nuf2 homolog
Sequence:
MSQYIKCYGRVRPSARLGAPSESLFVGGRVVTIETDNGSKRYELHHIFDSSSSQEDVFGTVAKKIVEDCVEGYNGTVFAYGQTGSGKTHTMLGPCDSWTDQELMGLIPRSVEHVFQHLDTKAKECQKLTFSVSVEFVELYNEVIYDLLNAKNKVQLRDSGKDIQLVGALSKNVDNPLDLMHLVQKGWQERSTGSTAMNAESSRSHALLIIRIKTQERTGELVKERSSILNLVDLAGSERQTHTKSSGDRLKEATNINSSLTVLGRCIRLLADPSKAKGHVPYRDSHLTHILKNSLGGNSKTAVIVNMHPDRDFAQESNSTLMFAQSCTMIMNIATRNEVMTGDQESSYKKAIQELRQEVDETREKVRTEFASQLDEAEVEQLRLKTENNSLRLENVDLRAKYDFALLKYTIGSENEQIVNEFKKIISEFSAANSSSPFECIALKNQTLQLEIEASEKRYQELQKETSALRNRYQENLDATILMQTPSAKERRSSSRPKRRETQYRPSPARMALFAEVETSEDAVLDLQCQNEKLSCELSSLKDKHEEATSKSIETERLLQGEIVALQKEVSIVSESLRKSEAVAEGYKEKVTANNLTLDKLLLHIDASRKRIAELELSSKESENRSSEELEEQRLYYVSMIEDLERKASDEYAALREELNQKTLSSNLLQVQVDELQLSNATIKKLNADLSTKAGLIRSLEDSIEKKSQMITRLEEQAVLDSSELSSTKRQLEHSRLEAIQWRKISEETTSAMQTQLKDHQKDIDQCRHKKKLEIQSMQLSLDNANARVKESEAMMKKLQNDEKQKFDMKMSEIENTFKEKLSVSLKKQEDTIRRQSLAENQGKLEVMENKNRVLSETIESLQSQHSQDTEVINAGLRTRGDRVGYVDKLRVEKKALEETISQLRSENDKLKKIMRGESANKPVLRSQTTKP
Protein: E3 ubiquitin-protein ligase ORTHRUS 2 (EC 2.3.2.27) (Protein VARIANT IN METHYLATION 1) (RING-type E3 ubiquitin transferase ORTHRUS 2) (Q8VYZ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Associates with methylated DNA, and can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate. Probably acts at the DNA methylation?histone interface to maintain centromeric heterochromatin.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00358, ECO:0000269|PubMed:17242155, ECO:0000269|PubMed:18643997, ECO:0000269|PubMed:18704160}. Note=Broadly distributed in the nucleus and enriched in the heterochromatic chromocenters.
Interaction partners:
- DNA
- Histone H3-like centromeric protein CENH3
- DNA
- DNA
- ATP-dependent DNA helicase DDM1
- DNA
- DNA
- Tetratricopeptide repeat
- Reverse transcriptase-like protein
- Boron transporter 4
Sequence:
MARDIQLPCDGDGVCMRCKSNPPPEESLTCGTCVTPWHVSCLSSPPKTLASTLQWHCPDCSGEIDPLPVSGGATGFESAGSDLVAAIRAIEADESLSTEEKAKMRQRLLSGKGVEEDDEEEKRKKKGKGKNPNLDVLSALGDNLMCSFCMQLPERPVTKPCGHNACLKCFEKWMGQGKRTCGKCRSIIPEKMAKNPRINSSLVAAIRLAKVSKSAAATTSKVFHFISNQDRPDKAFTTERAKKTGKANAASGKIYVTIPPDHFGPIPAENDPVRNQGLLVGESWEDRLECRQWGAHFPHVAGIAGQSTYGAQSVALSGGYKDDEDHGEWFLYTGSGGRDLSGNKRTNKEQSFDQKFEKSNAALKLSCKLGYPVRVVRSHKEKRSAYAPEEGVRYDGVYRIEKCWRKVGVQGSFKVCRYLFVRCDNEPAPWTSDENGDRPRPIPNIPELNMATDLFERKETPSWDFDEGEGCWKWMKPPPASKKSVNVLAPEERKNLRKAIKAAHSNTMRARLLKEFKCQICQQVLTLPVTTPCAHNFCKACLEAKFAGKTLVRERSTGGRTLRSRKNVLNCPCCPTDISDFLQNPQVNREVAEVIEKLKTQEEDTAELEDEDEGECSGTTPEEDSEQPKKRIKLDTDATVSATIR
Protein: Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) (P07910)
Organism: Homo sapiens (Human)
Function: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:37599448}. Note=Component of ribonucleosomes.
Interaction partners:
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Heterogeneous nuclear ribonucleoprotein A1
- CUGBP Elav-like family member 1
- Polypyrimidine tract-binding protein 1
- Heterogeneous nuclear ribonucleoprotein U
- ATP-dependent RNA helicase A
- Heterogeneous nuclear ribonucleoprotein M
- Heterogeneous nuclear ribonucleoprotein L
- RNA-binding motif protein, X chromosome
- Interleukin enhancer-binding factor 2
Sequence:
MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAAEMYGSVTEHPSPSPLLSSSFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGFNSKSGQRGSSKSGKLKGDDLQAIKKELTQIKQKVDSLLENLEKIEKEQSKQAVEMKNDKSEEEQSSSSVKKDETNVKMESEGGADDSAEEGDLLDDDDNEDRGDDQLELIKDDEKEAEEGEDDRDSANGEDDS
Protein: WD repeat protein mio zinc-ribbon like domain-containing protein (Q4GZ31)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Vacuolar membrane-associated protein Iml1 N-terminal domain-containing protein
- Small GTPase, putative
- WD repeat protein mio zinc-ribbon like domain-containing protein
- WD repeat protein mio zinc-ribbon like domain-containing protein
- Protein transport protein Sec13, putative
- Protein transport protein sec13, putative
- Ras-family member, GTP-binding protein, putative
- Mitochondrial inner membrane signal peptidase, putative
Sequence:
MNESHMCHQRPVCLNAFTKQPASSLALAPTAAVTHKVNSMKVQPTADALKSKITLNEGLTCIDFQPGRHLLAIGCTKVVHILEVKQLAEGNQSFTPTRSDSGKRGGAESEAFQSSHLPHSSGHMGLRQCGTFCNISKVEAVAWYPDTGEDVLAFVQRNRNITILFDTISVKSNRRVTKQWIHKASDRCLISSMEAGSSLSSTAVVNALNATCTPIFGGSAPEVPHPTFHAKRDREGRGMVEVIIPTGHNHVERIAWDPHNAYTLALAADATHFELWHIPVVDDHVHMPRLILRPPAHDERSTTRSVAFSPSNPNLIVVAVQLTNAGKVMIYDRRHVEVPRCVTTMGPCFAASFHPVYCDLLAVCCRKTKAKTDSRVQFFRVMDEMRPVGVLKLPAPASVDSGATTFHSTGANSAWPVTEQNILPPIDTVDPLNRLRWRPAVKGSQGTAVDVTVDSAEAIIDKISSQLWFATTSINGQEVSVWDASNVFCPIFSIKSISNRRNVSQRERTLREPTDCVWVNALTLVCVFKDGEVELISLFDEATESNETLFRCASETTTTSDPSSDTTINKMVDPGTFSLAAVLPTAAIVPDFFGQCLVVRNSSSALREYYANAIRADKGKILELMLLEYGAEWGSSISGDGITSSSAASFPISGTSSSTGLGAVSRGLRGTTRIAPVAQTPADRSQSSQINATFRHSHTRPLLPNSGSSVDRSRSPFVLGAETPGVATAGVASAAGRRHESLFPFLISLALQAQTTSTPRDNLPTTSAPAASSGDVLELAPDREKQQEEPHRTTASHVITAPPRRSNSTSHNGCADICYEKSPDGNARTVGMRPSHNAFLRQERQQMPAMSPSTPKIPCADILELVLPAVLCPNSASIISPLSLMGSGSDYSRCMLPNAGVAPGSCKSSEVLNSPLSDLPYTRGVPYSFREYGASGRSTSPRSSAVASPTGLPKHSLAQPLLLGVKSHVNPVIEHHIISSDMPNLTYVERLSEHDAFVRYAREWDVGYDVARKMISDRYSVRCSTDNTEYEERKEGQYLANKRHVDRRFARLMAHNAKVCFIHERTMRLKVGAYSREGIANSSCETEERGLCNDLNSFAGQSADIRGSLWASAKEIWRNHNVPYIASHVALLLDYASLTGDVQFCTVLYLLFCLWWEQRHGSMLSHPCPFLPSANANAREGHNRKSSQSAVTTSEVGGCSPQRWRLRALQWVEQYASRLYAMKLYVPINELLLVVPHVLGDSNSGLPRSEEIAQKLFTYLYCGVCRKTEIVPHHTMREKLGYLPSSLSEQLSLGRSGGEDDRQAKTDHSSDECTETCDSSGDSTPLSSMRSSSSSLSALDGKDTLGSVVGSEVIASERMKPTSAASYAGNEPSICGPVTYRNAVCRSCTSNSLMTCMICEEEVEGMYMWLRCCGHGGHVQHIEEWLSISNECPLCGVPIMMKE
Protein: Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) (Q9Y210)
Organism: Homo sapiens (Human)
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Podocin
- Nephrin
- Protein orai-2
- Stromal interaction molecule 1
- Short transient receptor potential channel 3
- cGMP-dependent protein kinase 1
- Transient receptor potential cation channel subfamily V member 4
- Short transient receptor potential channel 1
- Bone morphogenetic protein receptor type-2
- cGMP-dependent protein kinase 2
Sequence:
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR
Protein: Transcription initiation factor TFIID subunit 1 (TAFII250-A) (TBP-associated factor 1) (AtTAF1) (Transcription initiation factor TFIID subunit 1-A) (Q8LRK9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Core scaffold of the TFIID complex (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 6b
Sequence:
MAESNGKGSHNETSSDDDDEYEDNSRGFNLGFIFGNVDNSGDLDADYLDEDAKEHLSALADKLGSSLPDINLLAKSERTASDPAEQDYDRKAEDAVDYEDIDEEYDGPEVQVVSEEDHLLPKKEYFSTAVALGSLKSRASVFDDEDYDEEEEQEEEQAPVEKSLETEKREPVVLKEDKALEYEEEASILDKEDHMDTEDVQEEEVDELLEGTLDDKGATPLPTLYVEDGMVILQFSEIFAIHEPPQKRDRRENRYVTCRDKYKSMDISELVEDDEEVLLKSHGRIDTHVEQADLIQLDVPFPIREGLQLVKASTIGGITPESREFTKLGRDSCIMGELLKQDFIDDNSSLCQSQLSMQVFPLDQHEWERRIIWEHSPEISGNSGEIFEPGLEPEGMLVKGTNSETEQESLNVVNSRVQVQADNNMFVPFSANLLESFGSRGSQSTNESTNKSRHHPQLLRLESQWDENHLSGNDEAGVKKIKRLEKDALGRFSRLVLRERDLGDEAWLDSIIWDSEKELSRSKLIFDLQDEQMVFEIFDNEESKNLQLHAGAMIVSRSSKSKDETFQEGCESNSGWQFNLSNDKFYMNGKSSQQLQANTNKSSVHSLRVFHSVPAIKLQTMKSKLSNKDIANFHRPKALWYPHDNELAIKQQGKLPTRGSMKIIVKSLGGKGSKLHVGIEESVSSLRAKASRKLDFKETEAVKMFYKGKELDDEKSLAAQNVQPNSLVHLIRTKVHLWPWAQKLPGENKSLRPPGAFKKKSDLSTKDGHVFLMEYCEERPLMLSNAGMGANLCTYYQKSSPEDQRGNLLRNQSDTLGNVMILEPGDKSPFLGEIHAGCSQSSVETNMYKAPIFPQRLQSTDYLLVRSPKGKLSLRRIDKIVVVGQQEPRMEVMSPGSKNLQTYLVNRMLVYVYREFFKRGGGEHPIAADELSFLFSNLTDAIIKKNMKIIACWKRDKNGQSYWTKKDSLLEPPESELKKLVAPEHVCSYESMLAGLYRLKHLGITRFTLPASISNALAQLPDEAIALAAASHIERELQITPWNLSSNFVACTNQDRANIERLEITGVGDPSGRGLGFSYVRAAPKAPAAAGHMKKKAAAGRGAPTVTGTDADLRRLSMEAAREVLIKFNVPDEIIAKQTRWHRIAMIRKLSSEQAASGVKVDPTTIGKYARGQRMSFLQMQQQAREKCQEIWDRQLLSLSAFDGDENESENEANSDLDSFAGDLENLLDAEEGGEGEESNISKNDKLDGVKGLKMRRRPSQVETDEEIEDEATEYAELCRLLMQDEDQKKKKKKMKGVGEGMGSYPPPRPNIALQSGEPVRKANAMDKKPIAIQPDASFLVNESTIKDNRNVDSIIKTPKGKQVKENSNSLGQLKKVKILNENLKVFKEKKSARENFVCGACGQHGHMRTNKHCPRYRENTESQPEGIDMDKSAGKPSSSEPSGLPKLKPIKNSKAAPKSAMKTSVDEALKGDKLSSKTGGLPLKFRYGIPAGDLSDKPVSEAPGSSEQAVVSDIDTGIKSTSKISKLKISSKAKPKESKGESERRSHSLMPTFSRERGESESHKPSVSGQPLSSTERNQAASSRHTISIPRPSLSMDTDQAESRRPHLVIRPPTEREQPQKKLVIKRSKEMNDHDMSSLEESPRFESRKTKRMAELAGFQRQQSFRLSENSLERRPKEDRVWWEEEEISTGRHREVRARRDYDDMSVSEEPNEIAEIRRYEEVIRSEREEEERQKAKKKKKKKKLQPEIVEGYLEDYPPRKNDRRLSERGRNVRSRYVSDFERDGAEYAPQPKRRKKGEVGLANILERIVDTLRLKEEVSRLFLKPVSKKEAPDYLDIVENPMDLSTIRDKVRKIEYRNREQFRHDVWQIKYNAHLYNDGRNPGIPPLADQLLEICDYLLDDYEDQLKEAEKGIDPND
Protein: Transmembrane 9 superfamily member 4 (Endomembrane protein 10) (Transmembrane nine protein 4) (AtTMN4) (Q9FHT4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:P32802}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q940G0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Pentatricopeptide repeat-containing protein At1g74900, mitochondrial
- Pentatricopeptide repeat-containing protein At1g51965
- NADH dehydrogenase subunit 2.
- NADH-ubiquinone oxidoreductase chain 2
- Pentatricopeptide repeat-containing protein At3g22670
- NADH-ubiquinone oxidoreductase chain 5
- NADH-ubiquinone oxidoreductase chain 1
- DEAD-box ATP-dependent RNA helicase 53, mitochondrial
- Nuclear intron maturase 1, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
Sequence:
MVLLPSMTSLLLVFLFLYGVSPVISDGSDHRYKVGDDVPLYANKVGPFHNPSETYRYFDLPFCSSAPVKEKKEALGEVLNGDRLVSAPYKLEFLGEKNSEVACRKRLSREDVAKFRDVIAKDYYFQMYYDDLPIWGFLGKVVKEGKTDPSEYKYYLFNHLQFEIFYNKDRVIEIIVRTDQNFLVDLTEDKEVQVDFTYTVRWKETEIPFEKRMEKYSLASSMPHHLEIHWFSIINSCVTVLLLTGFLATILMRVLKNDFVKYAHDEEAVDDQEETGWKLIHGDVFRFPKHKSLLAAALGSGTQLFTLAVFIFMLALVGVFYPYNRGALFTALVVIYALTSGIAGYTAASFYCQLEGTNWVRNVILTGSLFCGPLLITFSFLNTVAIAYQATAALPFGTIVVIFLIWALVTSPLLILGGIAGKNRKSEFQAPCRTTKYPREIPPMRWYRRTLPQMAMAGFLPFSAIYIELYYIFASVWGHRIYTIYSILSIVFLILVIVTAFITVALTYFQLAAEDHEWWWRSLLCGGSTGLFIYAYCLYYYYARSDMSGFMQTSFFFGYMACICYGFFLMLGTIGFCASLLFVRHIYRSIKCE
Protein: PPARG related coactivator 1 (E7EVG6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAARRGRRDGVAPPPSGGPGPDPGGGARGSGWGSRSQAPYGTLGAVSGGEQVLLHEEAGDSGFVSLSRLGPSLRDKDLEMEELMLQDETLLGTMQSYMDASLISLIEDFGSLGESRLSLEDQNEVSLLTALTEILDNADSENLSPFDSIPDSELLVSPREGSSLHKLLTLSRTPPERDLITPVDPLGPSTGSSRGSGVEMSLPDPSWDFSPPSFLETSSPKLPSWRPPRSRPRWGQSPPPQQRSDGEEEEEVASFSGQILAGELDNCVSSIPDFPMHLACPEEEDKATAAEMAVPAAGDESISSLSELVRAMHPYCLPNLTHLASLEDELQEQPDDLTLPEGCVVLEIVGQAATAGDDLEIPVVVRQVSPGPRPVLLDDSLETSSALQLLMPTLESETEAAVPKVTLCSEKEGLSLNSEEKLDSACLLKPREVVEPVVPKEPQNPPANAAPGSQRARKGRKKKSKEQPAACVEGYARRLRSSSRGQSTVGTEVTSQVDNLQKQPQEELQKESGPLQGKGKPRAWARAWAAALENSSPKNLERSAGQSSPAKEGPLDLYPKLADTIQTNPIPTHLSLVDSAQASPMPVDSVEADPTAVGPVLAGPVPVDPGLVDLASTSSELVEPLPAEPVLINPVLADSAAVDPAVVPISDNLPPVDAVPSGPAPVDLALVDPVPNDLTPVDPVLVKSRPTDPRRGAVSSALGGSAPQLLVESESLDPPKTIIPEVKEVVDSLKIESGTSATTHEARPRPLSLSEYRRRRQQRQAETEERSPQPPTGKWPSLPETPTGLADIPCLVIPPAPAKKTALQRSPETPLEICLVPVGPSPASPSPEPPVSKPVASSPTEQVPSQEMPLLARPSPPVQSVSPAVPTPPSMSAALPFPAGGLGMPPSLPPPPLQPPSLPLSMGPVLPDPFTHYAPLPSWPCYPHVSPSGYPCLPPPPTVPLVSGTPGAYAVPPTCSVPWAPPPAPVSPYSSTCTYGPLGWGPGPQHAPFWSTVPPPPLPPASIGRAVPQPKMESRGTPAGPPENVLPLSMAPPLSLGLPGHGAPQTEPTKVEVKPVPASPHPKHKVSALVQSPQMKALACVSAEGVTVEEPASERLKPETQETRPREKPPLPATKAVPTPRQSTVPKLPAVHPARLRKLSFLPTPRTQGSEDVVQAFISEIGIEASDLSSLLEQFEKSEAKKECPPPAPADSLAVGNSGSSCSSSGRSRRCSSSSSSSSSSSSSSSSSSSSRSRSRSPSPRRRSDRRRRYSSYRSHDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR
Protein: Transcription initiation factor TFIID subunit 14 (SWI/SNF chromatin-remodeling complex subunit tfg3) (SWI/SNF complex subunit tfg3) (TBP-associated factor 14) (TBP-associated factor 30 kDa) (Transcription factor G 30 kDa subunit) (Transcription initiation factor TFIIF 30 kDa subunit) (O94436)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a component of the DNA-binding general transcription factor complex TFIID, and the RNA polymerase II associated general transcription factor complex TFIIF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, facilitation of DNA opening and initiation of transcription. TFIIF is essential for the initiation of transcription by RNA polymerase II. TFIIF functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. The TAF14 subunit has stimulatory activity. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:15616156, ECO:0000269|PubMed:16823372}.
Interaction partners:
- TATA-box-binding protein
- Transcription initiation factor IIF subunit beta
- SWI/SNF chromatin-remodeling complex subunit snf5
- Transcription initiation factor IIF subunit alpha
- RuvB-like helicase 1
- SWI/SNF chromatin-remodeling complex subunit snf22
- SWI/SNF chromatin-remodeling complex subunit snf30
- SAGA complex/transcription factor TFIID complex subunit Taf6
- SWI/SNF and RSC complexes subunit arp42
- Transcription initiation factor TFIID subunit 7
Sequence:
MTTVKRTVRLITDQNVLPGGEAAVLNDQSFPVREWSIKLVCLNPQGEETDASFVDRVTYKLHPTFQNPTRTIRKPPFQIKEQGWGEFEMEIIIYYADKGGEHRFLHYLHFQQEHYHEDIELNINATRPGLLKALTATGEVPGYSDEGEEARKDKRKNESEVGAGKKKAKAKPVDMDKLAEGLQKLQEDDLLQVVQMVNENKTPDMYVRNDIEGGEFHIDLYTLPDNLLLLLYSFCAKRVTM
Protein: Accessory gland protein Acp62F (O46202)
Organism: Drosophila melanogaster (Fruit fly)
Function: Responsible for physiological and behavioral changes in mated female flies. May contribute to the toxicity of seminal fluid and the decreased life-span of mated females. May also affect neuromuscular events after mating concerning sperm storage and egg release.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Accessory gland protein Acp36DE
- Accessory gland protein Acp29AB
- Accessory gland-specific peptide 70A
- Accessory gland-specific peptide 26Aa
- Accessory gland protein Acp76A
- Accessory gland protein Acp53Ea
- glutaminyl-peptide cyclotransferase
- Serpin 28F
- Accessory gland protein Acp63F
- Accessory gland-specific peptide 26Ab
Sequence:
MTDMWSLKICACLGLLLLFKPIDSMGWQGPKVDCTANGTQTECPVACPETCEYSGNGPCVKMCGAPCVCKPGYVINERIPACVLRSDCPKDVVRKEDMLLGVSNFKCFSRNYNCS
Protein: NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial (EC 1.14.13.253) (3-demethoxyubiquinone 3-hydroxylase (NADH)) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7) (Q99807)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis (By similarity). Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity). Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03194}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03194}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03194}. Mitochondrion {ECO:0000269|PubMed:25961505}. Nucleus {ECO:0000269|PubMed:25961505}. Chromosome {ECO:0000269|PubMed:25961505}.
Interaction partners:
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Ubiquinone biosynthesis protein COQ9
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- Atypical kinase COQ8A, mitochondrial
- Atypical kinase COQ8B, mitochondrial
- Dual specificity protein kinase CLK3
- All trans-polyprenyl-diphosphate synthase PDSS1
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
Sequence:
MSCAGAAAAPRLWRLRPGARRSLSAYGRRTSVRFRSSGMTLDNISRAAVDRIIRVDHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKDHLKKFNELMVTFRVRPTVLMPLWNVLGFALGAGTALLGKEGAMACTVAVEESIAHHYNNQIRTLMEEDPEKYEELLQLIKKFRDEELEHHDIGLDHDAELAPAYAVLKSIIQAGCRVAIYLSERL
Protein: Patched domain-containing protein 3 (Patched-related protein) (Q3KNS1)
Organism: Homo sapiens (Human)
Function: May play a role in sperm development or sperm function. However, does not appear to have an essential role in spermatogenesis or male fertility.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:17904097}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21439084}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the midpiece of the sperm tail. {ECO:0000269|PubMed:17904097}.
Interaction partners:
Sequence:
MPWVEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQDAPLPEGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEPTAICRHRHRCHTDCLEGLLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKAERRFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQDLRVAREKGSQIQYQQVCARYRALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGFFGGYILGGSLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILALKKIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVISAFLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKREVVCLCWLKKADPKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYLKGNSQDPNEKNTFMNNIPDFLSNFPNFQHDINISSSNEIISSRGFIQTTDVSSSAKKKILLFQLRRIAEDCQIPLMVYNQAFIYFDQYAAILEDTVRNVLVASAAMFIVSLLLIPYPLCSLWVTFAIGSVIVGVTGFMAFWKVNLDSISMINLVICIGFSFDFSVHISYAFVSSSQPSVNQKSVEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMIFGAAHGLIFIPVFLTFFGRFI