wanglab/gogpt-training-data huggingface dataset:
Protein: Kallikrein 1-related peptidase b21 (EC 3.4.21.35) (Glandular kallikrein K21) (mGK-21) (Tissue kallikrein 21) (Q61759)
Organism: Mus musculus (Mouse)
Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Displays trypsin-like substrate specificity and shows activity towards casein, gelatin, fibronectin and IGFBP3.
Interaction partners:
- Kallikrein 1-related peptidase b24
Sequence:
MRFLILFLALSLGEIDAAPPVQSRIVGGFNCEKNSQPWHVAVFRYNKYICGGVLLNPNWVLTAAHCYGNQYNVWLGKNKLFQHESSAQHRLVSKSFPHPDYNMSLMNDHTPHPEDDYSNDLMLLRLSKPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKWQIPNDLQCGFIKPLPNENCAKAYIHKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGVLQGITSWGSIPCAKPNAPAIYTKLIKFTSWIKDTMAKNP
Protein: Adenylate kinase (EC 2.7.4.3) (ATP-AMP transphosphorylase) (ATP:AMP phosphotransferase) (Adenylate kinase cytosolic and mitochondrial) (Adenylate monophosphate kinase) (Lethal protein 754) (P34346)
Organism: Caenorhabditis elegans
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
Subcellular location: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03168}. Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03168}. Note=Predominantly mitochondrial. {ECO:0000255|HAMAP-Rule:MF_03168}.
Interaction partners:
- Adenylosuccinate lyase
- Adenosine kinase
- Ribonucleoside-diphosphate reductase large subunit
- Adenine phosphoribosyltransferase
- Nucleoside diphosphate kinase
- Uroporphyrinogen-III synthase
- AMP deaminase
- Ribonucleoside-diphosphate reductase small chain
- Adenylate kinase isoenzyme 6 homolog
- Probable 3',5'-cyclic-AMP phosphodiesterase pde-4
Sequence:
MGVPKTQQSAQPATQSAGPTETLARGIRAIFIGPPGSGKGTQAPAFAQKYFSCHLATGDLLRAEVASGSEFGKELKATMDAGKLVSDEVVCKLIEQKLEKPECKYGFILDGFPRTSGQAEKLDEILERRKTPLDTVVEFNIADDLLVRRITGRLFHIASGRSYHLEFKPPKVPMKDDLTGEPLIRRSDDNEETLRKRLVQYHQMTVPLVDYYKKHGVHVAVDAAKPMTDVKAHIDQVFAKFTQKKERVSFV
Protein: Disco-interacting protein 2 homolog B (DIP2 homolog B) (Q9P265)
Organism: Homo sapiens (Human)
Function: Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin.
Subcellular location: Cell projection, dendrite {ECO:0000250|UniProtKB:Q3UH60}. Cell projection, axon {ECO:0000250|UniProtKB:Q3UH60}. Perikaryon {ECO:0000250|UniProtKB:Q3UH60}.
Interaction partners:
- DNA methyltransferase 1-associated protein 1
- Hydroxysteroid dehydrogenase-like protein 2
- Beta-alanine-activating enzyme
- Ral GTPase-activating protein subunit beta
Sequence:
MAERGLEPSPAAVAALPPEVRAQLAELELELSEGDITQKGYEKKRSKLLSPYSPQTQETDSAVQKELRNQTPAPSAAQTSAPSKYHRTRSGGARDERYRSDIHTEAVQAALAKHKEQKMALPMPTKRRSTFVQSPADACTPPDTSSASEDEGSLRRQAALSAALQQSLQNAESWINRSIQGSSTSSSASSTLSHGEVKGTSGSLADVFANTRIENFSAPPDVTTTTSSSSSSSSIRPANIDLPPSGIVKGMHKGSNRSSLMDTADGVPVSSRVSTKIQQLLNTLKRPKRPPLKEFFVDDSEEIVEVPQPDPNQPKPEGRQMTPVKGEPLGVICNWPPALESALQRWGTTQAKCSCLTALDMTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTKNEPVLKPGDRVALVYPNNDPVMFMVAFYGCLLAEVIPVPIEVPLTRKDAGGQQIGFLLGSCGIALALTSEVCLKGLPKTQNGEIVQFKGWPRLKWVVTDSKYLSKPPKDWQPHISPAGTEPAYIEYKTSKEGSVMGVTVSRLAMLSHCQALSQACNYSEGETIVNVLDFKKDAGLWHGMFANVMNKMHTISVPYSVMKTCPLSWVQRVHAHKAKVALVKCRDLHWAMMAHRDQRDVSLSSLRMLIVTDGANPWSVSSCDAFLSLFQSHGLKPEAICPCATSAEAMTVAIRRPGVPGAPLPGRAILSMNGLSYGVIRVNTEDKNSALTVQDVGHVMPGGMMCIVKPDGPPQLCKTDEIGEICVSSRTGGMMYFGLAGVTKNTFEVIPVNSAGSPVGDVPFIRSGLLGFVGPGSLVFVVGKMDGLLMVSGRRHNADDIVATGLAVESIKTVYRGRIAVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHISQTKQLFLEGSLHPCNILMCPHTCVTNLPKPRQKQPGVGPASVMVGNLVAGKRIAQAAGRDLGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAACILTSQTLMRLLRSREAAAAVDVKTWPTIIDTDDLPRKRLPQLYKPPTPEMLAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLIPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCVRTCVVVAEERPRVALQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFLADQLDPIYVAYNM
Protein: MARVEL domain-containing protein 2 (Tricellulin) (Q8N4S9)
Organism: Homo sapiens (Human)
Function: Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28661558}; Multi-pass membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000269|PubMed:28661558}. Note=Located at tricellular contacts. {ECO:0000269|PubMed:28661558}.
Interaction partners:
- Tight junction protein 1
- Tight junction protein 2
- Tight junction protein ZO-3
- Occludin
- Cingulin
- Claudin-7
- Lipolysis-stimulated lipoprotein receptor
- Junctional adhesion molecule A
- MARVEL domain containing 3
- Claudin-3
Sequence:
MSNDGRSRNRDRRYDEVPSDLPYQDTTIRTHPTLHDSERAVSADPLPPPPLPLQPPFGPDFYSSDTEEPAIAPDLKPVRRFVPDSWKNFFRGKKKDPEWDKPVSDIRYISDGVECSPPASPARPNHRSPLNSCKDPYGGSEGTFSSRKEADAVFPRDPYGSLDRHTQTVRTYSEKVEEYNLRYSYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDSEWYNLFGYSQPYGMGGVGGLGSMYGGYYYTGPKTPFVLVVAGLAWITTIIILVLGMSMYYRTILLDSNWWPLTEFGINVALFILYMAAAIVYVNDTNRGGLCYYPLFNTPVNAVFCRVEGGQIAAMIFLFVTMIVYLISALVCLKLWRHEAARRHREYMEQQEINEPSLSSKRKMCEMATSGDRQRDSEVNFKELRTAKMKPELLSGHIPPGHIPKPIVMPDYVAKYPVIQTDDERERYKAVFQDQFSEYKELSAEVQAVLRKFDELDAVMSRLPHHSESRQEHERISRIHEEFKKKKNDPTFLEKKERCDYLKNKLSHIKQRIQEYDKVMNWDVQGYS
Protein: Disease resistance protein (TIR-NBS class) (Disease resistance protein, putative) (Putative disease resistance protein) (Q9C515)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RING/U-box superfamily protein
- Putative FBD-associated F-box protein At5g44940
- At4g27652
- Probable LRR receptor-like serine/threonine-protein kinase At4g37250
- AT5g23340/MKD15_20
- Probable disease resistance protein At5g45490
- Expressed protein
- At1g66080
- At4g27654
- Uncharacterized calcium-binding protein At1g02270
Sequence:
MAASTSSSSSSSSSSLSSPSPCTWRYMTFTSFHGPDVRNTFLSHLRKQFNTNGITMFDDQRMERSQTLAPTLTQAIRESKIYIVLLSKNYASSSWCLDELLEILNCKEKRGQRVMTIFYGVNPSDVRKQTGEFGIAFNETCARKTEEERRKWSHALTCVGNITGVHVQDRDDEANMIEKIATDVSEKLNATESKDFDEMVGIKAHLTKIESLLSLDYDKVKIVGISGPAGIGKSTIARALHNLLSSSFHLSCFMENLISQSNPHSSLEYSSKLSLQEQLLSQVLNEKDIRIRHLGAIQERLHDQRVLIILDDVTSLEQLEVLANIKWYGPGSRIIVITKKKDILVQHGICDIYHVGFPTDADALKIFCLSAYRQTSPPDGSMKIHECEMFIKICGNLPLHLHVLGSALRGRSYGRVQSLCNLVSLADFV
Protein: Armadillo repeat protein involved in nucleocytoplasmic transport Syo2 (Q9P7W7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ribosome production factor 2 homolog
- Brix domain-containing protein C1B9.03c
- mRNA export factor rsm1
- Large ribosomal subunit protein uL18B
- Large ribosomal subunit protein uL18A
- Periodic tryptophan protein 2 homolog
- Pumilio homology domain family member 6
- Protein sda1
- Probable nucleolar GTP-binding protein 1
- 25S rRNA
Sequence:
MGRANGKRRNHRKNRMNPIQKKGFLEQEIPLNNSEAALPLLSRLDNPEIKERSWACSAISNIIASCTEGRLYLLKNGLVSKLIDRISDDSVEVVVEATGALRNLAIEEGYSICMDMYRKNVLAPLQIWQTKIVQTLDEATEGKNVLETYEDRSTFSCLCAIAENISSLLVNLGETTSQVIKVLNQKNTLVFLSRLLIPEAKIPQSVQEMALQAFFTLTDDNDDGIITWIQNSSDFALKTINQIYLYFSYPSCLVRVYSIGIIYNIYQSGFVNKKMESVVKGISLFDSFIPEALPILSDLLPSEENYRNLVRQVYDKDTYFKTKKDDLTLSSELLVIPATLELISSMTSLLQSLADGTDELEEQEDSLMEDEDLSYMDDMSNVVNEDENLIIDEIPSNTPQKGNFKLVEYMLDHVLPKVITYCVVAFEFSSEEIPSNLSNYFQEVGDRTIECLNNISWSCNSVFVESSEAFTRWKLSAGKILQWIFQTIFLRLGLGVWPFSSEGFTTACSLLWSVSKPFPAEIQVLSVDDISTLILFSSTHGSLEAQSRLLGAFGSLGRCGNIQINQLLGQTLMSCVIASDPNPLLAVEALNAIFDVYGDKSYPYDAPVFKGSGYLSQLSEALPRLKNMVKKIDRRREKHLRFRAEEALENLESFIDYKHAEYAS
Protein: ATP-dependent RNA helicase glh-3 (EC 3.6.4.13) (Germline helicase 3) (O01836)
Organism: Caenorhabditis elegans
Function: Probable ATP-binding RNA helicase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21402787}.
Interaction partners:
- Guanyl-specific ribonuclease pgl-3
- Guanyl-specific ribonuclease pgl-1
- Enlarged germline granules protein 1
- P-granule-associated protein deps-1
Sequence:
MDKSPTKTSIRTKFARHQPISDVDTTEQSSSCIKKDDRGLSSFGVQSSVFSRRSCRMSELEAKPTIISEDQRIAVRSEIGGSFSGFDDKVDNVFHSNNNLHGSPSTTELECPGIMNPRFLVGRSLNSRSRAVTRGSKRTSNVKENEGSIHRSDDQVSTENCSAKDEERDRDSGGVSSYGNKRSDEFCGTSPILEAKGFGISNTCFNCKKYGHRATECSAPQRECANCGDPNHRANECASWSKNGVQEPTKVTYVPVVDKMEEVFSMLKINAGDFFDKFFDASVQLVSRGQPVTIQPCKSFSDSDIPQSMRRNVERAGYTRTTPIQQYTLPLVADGKDILACAQTGSGKTAAFLLPIMSRLILEKDLNYGAEGGCYPRCIILTPTRELADQIYNEGRKFSYQSVMEIKPVYGGINVGYNKSQIMKGCTIIVGTIGRVKHFCEDGAIKLDKCRYLVLDEADRMIDSMGFGPEIEQIINYKNMPKNDKRQTMMFSATFPSSVQEAARKLLREDYTMITIDKIGAANKCVIQEFELCDRTSKVDKLLKLLGIDIDTYTTEKNSDVFVKKTIVFVAQQKMADTLASIMSAAQVPAITIHGAREQKERSAALKLFRSGAKPVLIATAVVERGLDIKGVDHVINYDMPNNIDDYIHRIGRTGRVGNSGRATSFISLADDVQILPQLVRTLADAEQVVPSWMKEAAGGTSNPNKFEKSIDTEEPEEAW
Protein: Truncated MHC class I antigen splice variant Bl.2 (Q4VCN4)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAQRTLFLLLAAALTMIETRAGPHSMRYFETAVFRPGLGEPRFISVGYVDNTQFVSFDSDAENPRSEPRAPWMEQEGPEYWERETQIAKDNEQSFGWSLRNLIHYYNQSKGDPPKAHVTHHPRPAGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPLGKEQNYTCHVYHEGLPEPLTLRWEPPPSTGSNMVNIAVLVVLGAVIIIEAMVAFVLKSSRKIAILPGPAGTKGSSAS
Protein: Eukaryotic translation initiation factor 5B (Translation initiation factor IF-2) (Q4WK23)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- 40S ribosomal protein S3
- 40S ribosomal protein S15, putative
- Eukaryotic translation initiation factor 1A
- 60S ribosomal protein L23
- Small ribosomal subunit protein uS5
- 60S ribosomal protein L8, putative
- 60S ribosomal protein L5, putative
- 40S ribosomal protein S5, putative
- TeaA receptor TeaR
- 40S ribosomal protein S9
Sequence:
MAPKKKGNRKQDDDWEAELGESIAPVSEQPKDATPADAAPEEDDMGGGLLAALRKNKNKKAKKGKPVNDFVEGEDATEQANGDVDFSSKQPEEGTVDQEDVFAGKKKQKPAKATPPAPASVEGDGEIRVKTKKEKEREKKEREKQRKREQALKKKATAPEPKAEPAKAEKKEQAAPAAAAAPTPPAAAPEAPGKKKKLPAHLAAIQRQQEALRRQREEEERRLAEEKAAEEERLRREAEEEKKREEARQRRKEKEREKKEQLRREGKLLTKAQKEAKERNELRLKQMLAAGVGKVAGLEEPGIEKKKPVYDNRKRKGLKKQEEDLEAAAARARAQREAEEERRRKEEEEKKAKAEAEAAAAAAAAGDEESEVDDWEKAAEAEEEVKDSWDAPSEDEGEKPATNGVAKPAAAPQQKAEVHESESEDDSEDDSESESEDEEKSAAQKAIAQRKAEAAERRKKQHEEALAARSKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVDALRQKTAVVNKDGKFEFKIPGLLVIDTPGHESFSNLRSRGSSLCNIAILVVDIMHGLEPQTLESMRLLRERKTPFIVALNKIDRLYGWKKIDNNGFQDSLAMQSKGVQNEFRTRLEHTKLLFAEQGFNAELYYENKSMARNVSLVPTSAHTGEGIPDMLKLLTTLTQERMTNSLMYLSEVECTVLEVKVIEGLGTTIDVVLSNGILREGDRIVLCGLNGPIATNIRALLTPAPLKELRLKSQYVHNKEVKAALGVKIAANDLEHAIAGSRLMVVGPDDDEEDIEEEVMSDLENLLSKVSRDQRGVSVQASTLGSLEALLEFLRVSKIPVANISIGPVYKRDVMMCGTMLEKAKEYAVMLCFDVKVDKEAAAYAEEVGVKIFTADIIYHLFDDFTKHMAELTEKRKEESKLLAVFPCVLRPVAVFNKKDPIVIGLDVIEGSLRMHTPISAVKTNPTTGAKEIIDLGRVVSIERDHKPIQVCKKGQPSVAVKIEGANQPMYGRQLEEKDTLYSHISRASIDTLKEFYRSDVSMEEWALIKKLKPVFDIP
Protein: Penicillin acylase family protein (Q9I6I6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
Interaction partners:
Sequence:
MKRTLTVIAVAVAAAAAGGAWYLHAKQPLRNGSLALAHLQAPVDVRYDERGVPHLYAQNQTDLYRALGYVHAQDRLFQMEMLRRLARGELAEVLGPKLVDTDRLFRTLRIRDHAAEYSARQDKQSQPWKVLEAYLDGVNQFQENNPAPLEFDLLGIPRRPFTPEDTLSIAGYMAYSFAAAFRTEPVLTYIRDELGSDYLRIFDLDWHPQGVLTPSGALGAGDWKDLGALARLSQQALEDAGLPQFEGSNAWVVAGSRTASGKPLLAGDPHIRFAAPAVWYEAQLSAPGFELYGHHQALNPFASLGHNRAFGWSLTMFQNDDLDLVAEKVNPDNPNQVWYQGEWVDLQSEEQEIAVKGAAPVKLTLRRSPHGPIVNDALGASSGKTPIAMWWAFLETENPVLDAFYQLNRADTLAKARAAASKIHSPGLNLVWANAAGDIGWWASAALPKRPEGVNPSFILDGSKGEADKSGFYPFADNPQEENPARGYIVSANFQPVPANGRPIPGYYNLADRGQWLDTQLADRGTKWNLDNSRALQLGNRTGYAPRLLAPLLPVLREVVDDAEGKRLVEQLAAWNGDYPVDSTAATLFNQLLFQIAEGALHDELGDAFFDSLIATRAIDSALPRLAGDADSPWWDDRRTERRETRADIVRTAWNASLAHLRGTLGNDPSGWLWGKAHTLTHEHALGQQALLRRLLNVGPFAAPGTHEVPNNLSAKIGPAPWAVTYGPSTRRLVDFADPTHSLGINPVGQSGVPFDGHYDDQAEAYIEGHYLPQHYEENEVKANSKGVLVLEPKR
Protein: Zinc finger protein GLI4 (Krueppel-related zinc finger protein 4) (Protein HKR4) (P10075)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGSPGSSPKVLSQPSDLDLQDVEEVEIGRDTFWPDSEPKPEQAPRSPGSQAPDEGAGGALRSLLRSLPRRARCSAGFGPESSAERPAGQPPGAVPCAQPRGAWRVTLVQQAAAGPEGAPERAAELGVNFGRSRQGSARGAKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE
Protein: Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) (Q9NRR4)
Organism: Homo sapiens (Human)
Function: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.
Subcellular location: Nucleus {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:22118463}. Nucleus, nucleolus {ECO:0000269|PubMed:10948199}. Cytoplasm {ECO:0000250|UniProtKB:Q5HZJ0}. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:22118463}.
Interaction partners:
- Probable ATP-dependent RNA helicase DDX5
- Microprocessor complex subunit DGCR8
- Probable ATP-dependent RNA helicase DDX17
- Cellular tumor antigen p53
- Protein argonaute-2
- TAR DNA-binding protein 43
- RNA-binding protein FUS
- Endoribonuclease Dicer
- RISC-loading complex subunit TARBP2
- Protein argonaute-1
Sequence:
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYDRGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDETEDIKK
Protein: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp) (P0C312)
Organism: Oryza sativa (Rice)
Function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Subcellular location: Plastid, chloroplast stroma {ECO:0000255|HAMAP-Rule:MF_00444}.
Interaction partners:
Sequence:
MPIGVPKVPYRIPGDEEATWVDLYNVMYRERTLFLGQEIRCEVTNHITGLMVYLSIEDGISDIFLFINSPGGWLISGMAIFDTMQTVTPDIYTICLGIAASMASFILLGGEPTKRIAFPHARIMLHQPASAYYRARTPEFLLEVEELHKVREMITRVYALRTGKPFWVVSEDMERDVFMSADEAKAYGLVDIVGDEMLDEHCDTDPVWFPEMFKDW
Protein: Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) (Preimplantation protein 4) (Q8C0L9)
Organism: Mus musculus (Mouse)
Function: May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:20576599}.
Interaction partners:
- Acyl-protein thioesterase 1
- Choline kinase alpha
- Choline/ethanolamine kinase
- Acyl-protein thioesterase 2
- Patatin-like phospholipase domain-containing protein 7
- Patatin-like phospholipase domain-containing protein 6
- Choline O-acetyltransferase
- Phospholipase B1, membrane-associated
- Ethanolamine kinase 1
- Acetylcholinesterase
Sequence:
MTPSQVTFEIRGTLLPGEVFAICGSCDALGNWNPQNAVALINENETGDSVLWKAVIALNRGVSVKYRYFRGCFLEPKTIGGPCQVIVHKWETHLQPRSITPLESEIIIDDGQFGIHNGVETLDSGWLTCQTEIRLRLHFSEKPPVSISKKKFKKSRFRVKLTLEGLEEDEDDDDDKVSPTVLHKMSNSLEISLISDNEFKCRHSQPECGYGLQPDRWTEYSIQTMEPDNLELIFDFFEEDLSEHVVQGDVLPGHVGTACLLSSTIAESGRSAGILTLPIMSRNSRKTIGKVRVDFIIIKPLPGYSCSMQSSFSKYWKPRIPLDVGHRGAGNSTTTAKLAKVQENTIASLRNAASHGAAFVEFDVHLSKDFVPVVYHDLTCCLTMKRKYEADPVELFEIPVKELTFDQLQLLKLSHVTALKTKDRKQSLYEEENFFSENQPFPSLKMVLESLPENVGFNIEIKWICQHRDGVWDGNLSTYFDMNVFLDIILKTVLENSGKRRIVFSSFDADICTMVRQKQNKYPILFLTQGKSDIYPELMDLRSRTTPIAMSFAQFENILGINAHTEDLLRNPSYVQEAKAKGLVIFCWGDDTNDPENRRKLKEFGVNGLIYDRIYDWMPEQPNIFQVEQLERLKQELPELKNCLCPTVSHFIPSSFCVEPDIHVDANGIDSVENA
Protein: DNA topoisomerase I mitochondrial (E5RJ95)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLDHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRA
Protein: H1 histone family, member X (H1.10 linker histone) (Q80ZM5)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU003894}.
Interaction partners:
- Histone H1.8
- Testis-specific H1 histone
- Histone H1.9
Sequence:
MSVELEEALPPTSADGTARKTAKAGGSAAPTQPKRRKNRKKNQPGKYSQLVVETIRKLGERGGSSLARIYAEARKVAWFDQQNGRTYLKYSIRALVQNDTLLQVKGTGANGSFKLNRKKLEGGAERRGASAASSPAPKARTAAADRTPARPQPERRAHKSKKAAAAASAKKVKKAAKPSVPKVPKGRK
Protein: TU4 isoform B (B2M0R5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MKCGTELMQKSQEMLQRLSHLGRENMEKLKASEVRLGEHLRSLQTMITDLEKNCGESAVALLQNAECYLKRNESILLQSLEPAQITDLSSCQIIETSRVLLRLQRHITLDPGTAHPSLVLSEDLRSVGFRETPKTGPGTTRRLDFGASVLGAESFTTGRHYWEVAVGQATQWQVGICDCTERKGNIPGASGDKVLLMGSMMGTDCTLWVFPPLRKVCLRNQMYKVGVFLDCECGQVSFYNVTEQSLIYSFSDLTFRGAVKPIFSLRIPNGGMSSDSLTVCLSQTHP
Protein: Clu domain-containing protein (Q381V9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVRLPPIVQGSQADGIQRRQSVATAPAARSAARRGSIRFKKSLIYWKLFGASAPLYCGPLGEVVGEVEEGTVIRETRRYRDPFGNWWVASRSVDDSLLWLLFSSPPSSDGEVGQWRRVYDQQDQDIPSSPRTEEVAVLGSYSIPPEVSTKELPSLDDVHQFIRVLGKSWRAMTSNPAAHTRDWNTQYQQLVEQNLFAEREASTSARDQLRCFMEEFKAAAEEAALGVVAELVLPAELRSGRGVTGERNYFARNGLLVRVMLDDCDDEENKGSEQAWQVATQFFLAQQVLSLEAPKQLFHTLPTALVTFCGVRVCVFAIAPIELQNVVYLPIQELERGNLETPNFVQRRLGELGAAISLKGHVLKGAEGKSVDVAMSADVALIKGYDKRLYIIGSGRLLPELALLGNEENMKDPTKCNLWDDTLTTLRFRPEFLLRWSAPLNPDAFVESTATPEDNATIVEATEYIRAKLIPTVAAMVGLHEPIDIPRQDAVECTLCGNTLTNELRFVVCRSNEKCCHICSHCYARRLSEQGDSTRDIFCDAVKCGAGFRGPKGLLMQPSLSSIFHANGLNMRFLPFVYHAIPAGAKPVVGHYCEIEMVARAAVRVFRNKLRSTSQVIDEVRQISQDLFLGLLQSSGHVPERFWADEIGPTIEKMYGPLEPFNTEKMDVELLYHRVADLSGIVLSSSSVESLYGEERPFLQLESVEPVVKVVVPPYVADEEAQEELRRGLYDSLGETLLFWIGAFTDGVEGSTSGGKLPHEPFYLTEQPI
Protein: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Q2I823)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MAEERNYIIKVEEGKAATDERPSIGPVYRSCFAENGFPAPIPGMESCWDIFRMSVEKYPNHHMLGHRQIVDGKAGKYVWQTYKQVYDIVMKVGNSIRSCGVEEGGKCGIYGANCPEWIMTMEACNAHGLSCVPLYDTLGADAVEFIICHAEVSIAFVEEKKIAELFKTFPNSTKYLRTIISFGKVTPEQKAEAEKQGLAIFTWEEFLQLGENKQYDLPIKKKTDICTIMYTSGTTGDPKGVLISNESIITLLAAVDCLLGRVNEELTMNDVYISYLPLAHIFDRVIEELFISHGASIGFWRGDVKLLLEDIGELKPSVFCAVPRVLDRIYSGLQQKISEGGLLKKTLFNVAYSFKFYNMRNGSKHAEASPFSDRIVFSQVKERLGGNLRIILSGAAPLSSHVEEFLRVVACCHVMQGYGLTETCAGTFVSLPHELSMLGTVGPPVPNVDVRLESVPEMGYDALASTPRGEICLKGTTLFSGYFKREDLTKEVMIDGWFHTGDIGEWQPNGSMKVIDRKKNIFKLSQGEYVAVENLENVYGCVSDIESIWVYGNSFESYLVAVVNPNKQALERWAADNGVSGDFETICKDPKAKEYILGELTRTGKEKQLKGFEFIKAVHLDHVPFDMDRDLLTPTFKKKRPQLLKYYQSVIDDMYNSINKPNA
Protein: Mitochondrial import receptor subunit TOM22 (Mitochondrial 17 kDa assembly protein) (Mitochondrial 22 kDa outer membrane protein) (Protein MAS17) (Translocase of outer membrane 22 kDa subunit) (P49334)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating.
Subcellular location: Mitochondrion outer membrane; Single-pass type II membrane protein.
Interaction partners:
- Mitochondrial import receptor subunit TOM6
- Mitochondrial import receptor subunit TOM20
- Sorting assembly machinery 37 kDa subunit
- Mitochondrial import receptor subunit TOM40
- Sorting assembly machinery 50 kDa subunit
- Mitochondrial import receptor subunit TOM70
- Mitochondrial import receptor subunit TOM5
- Mitochondrial import receptor subunit TOM7
- Sorting assembly machinery 35 kDa subunit
- Mitochondrial import inner membrane translocase subunit TIM21
Sequence:
MVELTEIKDDVVQLDEPQFSRNQAIVEEKASATNNDVVDDEDDSDSDFEDEFDENETLLDRIVALKDIVPPGKRQTISNFFGFTSSFVRNAFTKSGNLAWTLTTTALLLGVPLSLSILAEQQLIEMEKTFDLQSDANNILAQGEKDAAATAN