wanglab/gogpt-training-data huggingface dataset:
Protein: Menin (Q7KXY9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MALNGVIDASLFPLKSTADVINLFRRALTSGIEPDLTLLSIVVGYIELSLTTGEAAAQAAQAAAAAVAAGDISQATTGGNDIIMGNSVPFPVVTHELIAGLYKKFQTILSVVEKPKPHRQATREVIKKVSDVIWNSLIRSSYKDRAHLQNLYSYLSGNKLDCFGVALAVVAGCQLLGYKDVRLAISEDHAWVVFGQKRVETIEVTWHGKGSEDKRGQDIRPGIESGSWLYLGGLAVVCERGMEVAAICAALNISLTSNSDCVEVAELQQQLLWLLYDLGHLKRYPMALGTLGELEEIHRTHPSISCEQLYREAIESARTHYRNHHVYPYTYQGNYYNRLLKYRDAFAAWANAADVIRLYTYQCRDDEEIYKELLDIANELIPYVMKTESSGHSARSILRDSEVFANLLRFYDGICQWEEDSLTPILHIGWAKPLVNNITKFDYDIRSQVVIKLPEDLEAEQAKAELARAEQEAKEAKESKEAAGSEAMEGNNNRMATKEEKSKNSELPTTLADLTAACGEKILNPDFLLQGGGQPFADQKQQPSGGESDNPELHNNNNNSNSNNNNNNHNADKKEAAATTTNATTTSNGSGTSVQLPVSSEANNAGQAQSQVQINDQLGKPQHKEAKKEETSDDYDPFEIMLKRPVITLYSQKMKGLKDLLLAEKLNTHAISLQVTAQSVASRKVRGVEKHSATISATITAISSSSGDSVLSGVGGGGGSGSAVTGGASLASSSLGGDSIAASRPKRTRRE
Protein: Enolase A (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase A) (2-phosphoglycerate dehydratase A) (Q54RK5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Pyruvate kinase
- Probable phosphoglycerate mutase
- Glucose-6-phosphate isomerase
- Phosphoenolpyruvate carboxykinase, mitochondrial
- Phosphoglycerate kinase
- Fructose-bisphosphate aldolase
- Transketolase
- Phosphoenolpyruvate carboxykinase
- Cleavage stimulation factor subunit 3
- Triosephosphate isomerase
Sequence:
MSVIKSIKAREILNSRGNPTVEVDLYTEKDGVVSSFRAAVPSGASTGIYEAVELRDGDKSRYLGKGVLKAIKNILEVIQPAVIGKSVSDQAAIDKLMIDLDGTPNKGKLGANAILAVSLAVCRAGAADRNLPLYKYISEIAGTKMRLPVPAFNVINGGSHAGNKLAMQEFMILPVGAKDFNEAYRMGSEVYHNLKNVISGRYGQDAINVGDEGGFAPPIQSNKEGLELLKLAIEKAGYTGLVKIGMDCAASEFKVENGYDLDFKTKNNDGSAVISGEKLGDLYREFIKEYPIISIEDPFDQDDWESYTKLTASVDIQIVGDDLLVTNPERIKTGIEKKACNALLLKVNQIGSVTESIRAALDSKNASWGVMVSHRSGETEDTFIADLVVGLGTGQIKTGAPCRSERLAKYNQLVRINEELGENHNYAGLTFRKF
Protein: Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein homolog) (P21565)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. srp54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. srp54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, srp54 and srp101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, srp54 and srp101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P20424}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P20424}.
Interaction partners:
- Signal recognition particle subunit srp72
- Signal recognition particle sec65 subunit
- Signal recognition particle subunit srp14
- Signal recognition particle subunit srp68
- Uncharacterized protein C17H9.07
- Signal recognition particle receptor subunit alpha homolog
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein bL19m
- Signal recognition particle receptor subunit beta
Sequence:
MVFADLGRRLNSALGDFSKATSVNEELVDTLLKNICTALLETDVNVRLVQELRSNIKKKINVSTLPQGINGKRIVQKAVFDELCSLVDPKVDAFTPKKGRPSVIMMVGLQGSGKTTTCSKLALHYQRRGLKSCLVAADTFRAGAFDQLKQNAIKARVPYFGSYTETDPVVIAKEGVDKFKNDRFDVIIVDTSGRHQQEQELFAEMVEISDAIRPDQTIMILDASIGQAAESQSKAFKETADFGAVIITKLDGHAKGGGALSAVAATKTPIVFIGTGEHINDLERFSPRSFISKLLGLGDLEGLMEHVQSLDFDKKNMVKNLEQGKFTVRDFRDQLGNIMKLGPLSKMASMIPGMSNMMNGMNDEEGSLRMKRMLYIVDSMTEQELDSDGLLFVEQPSRVLRVARGSGTSVLEVEETISQVRVFAQMAKKIGGKDGILGKLGGNPAAALKKDPRQLAAMQKRMQAMGMGGGMPGLNPGSMNFGDISKMANMLMGGGGPGGAGGMDFSGMLNQFQNMQKPPRRR
Protein: ETHYLENE INSENSITIVE 3-like 3 protein (O23116)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that may be involved in the ethylene response pathway.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ethylene-insensitive protein 2
- EIN3-binding F-box protein 1
- Ethylene-responsive transcription factor 1B
- EIN3-binding F-box protein 2
- Ethylene-responsive transcription factor 2
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 6
- Sulfate transporter 1.2
- Serine/threonine-protein kinase CTR1
Sequence:
MGDLAMSVADIRMENEPDDLASDNVAEIDVSDEEIDADDLERRMWKDRVRLKRIKERQKAGSQGAQTKETPKKISDQAQRKKMSRAQDGILKYMLKLMEVCKVRGFVYGIIPEKGKPVSGSSDNIRAWWKEKVKFDKNGPAAIAKYEEECLAFGKSDGNRNSQFVLQDLQDATLGSLLSSLMQHCDPPQRKYPLEKGTPPPWWPTGNEEWWVKLGLPKSQSPPYRKPHDLKKMWKVGVLTAVINHMLPDIAKIKRHVRQSKCLQDKMTAKESAIWLAVLNQEESLIQQPSSDNGNSNVTETHRRGNNADRRKPVVNSDSDYDVDGTEEASGSVSSKDSRRNQIQKEQPTAISHSVRDQDKAEKHRRRKRPRIRSGTVNRQEEEQPEAQQRNILPDMNHVDAPLLEYNINGTHQEDDVVDPNIALGPEDNGLELVVPEFNNNYTYLPLVNEQTMMPVDERPMLYGPNPNQELQFGSGYNFYNPSAVFVHNQEDDILHTQIEMNTQAPPHNSGFEEAPGGVLQPLGLLGNEDGVTGSELPQYQSGILSPLTDLDFDYGGFGDDFSWFGA
Protein: Tetrahydromethanopterin S-methyltransferase subunit H (EC 7.2.1.4) (N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H) (P80187)
Organism: Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
Interaction partners:
- Tetrahydromethanopterin S-methyltransferase subunit G
- Tetrahydromethanopterin S-methyltransferase subunit C
- Tetrahydromethanopterin S-methyltransferase subunit A 2
- Tetrahydromethanopterin S-methyltransferase subunit E
- Tetrahydromethanopterin S-methyltransferase subunit B
- Tetrahydromethanopterin S-methyltransferase subunit D
- Tetrahydromethanopterin S-methyltransferase subunit A 1
- Tetrahydromethanopterin S-methyltransferase subunit F
- Methyl-coenzyme M reductase I subunit alpha
- Methyl-coenzyme M reductase I operon protein C
Sequence:
MFRFDKEQIVLDIAGTKIGGQPGEYPTVLAGTIFYGGHSIIEDEKAGVFDKDKAEALIKTQEEMSDVTGNPHIVQTFGQTPEAIVKYLEFVGDITDAPFFIDSTSGEARIAGAEYASEVGLEDRAIYNSVNMAADESELEALKNTKLSASIVLGFNPMDPTVEGKIGIWEDGAGTIDKGLLEMAADCGIDKYLMDVAVTPLGQGAGVAVRTSFAVKSKWGYPVGSGIHNVPSAWDWLREYKKEHKEAWPVCDVGSNLIQQMAGGDFVLYGPIENARMAFPACAMADIFISEAAKDIGTEAVEDHPFFKLL
Protein: ABC transporter B family member 19 (ABC transporter ABCB.19) (AtABCB19) (Multidrug resistance protein 11) (P-glycoprotein 19) (Q9LJX0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin efflux transporter that acts as a negative regulator of light signaling to promote hypocotyl elongation. Mediates the accumulation of chlorophyll and anthocyanin, as well as the expression of genes in response to light. Participates in auxin efflux and thus regulates the polar auxin basipetal transport (from auxin-producing leaves to auxin-sensitive tissues, and from root tips to root elongating zone). Involved in diverse auxin-mediated responses including gravitropism, phototropism and lateral root formation.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase FKBP42
- Auxin efflux carrier component 2
- Auxin efflux carrier component 1
- Auxin efflux carrier component 3
- Auxin efflux carrier component 7
- Auxin transporter protein 1
- Auxin transporter-like protein 3
- Phototropin-2
- Auxin efflux carrier component 4
- Phototropin-1
Sequence:
MSETNTTDAKTVPAEAEKKKEQSLPFFKLFSFADKFDYLLMFVGSLGAIVHGSSMPVFFLLFGQMVNGFGKNQMDLHQMVHEVSRYSLYFVYLGLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDARTGDIVFSVSTDTLLVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFAGGLYAYTLTGITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAKGLGLGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIFSAIVGGMSLGQSFSNLGAFSKGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDVMIFRNFNIFFPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVNQEPALFATTILENILYGKPDATMVEVEAAASAANAHSFITLLPKGYDTQVGERGVQLSGGQKQRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRVMVGRTTVVVAHRLCTIRNVDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEMVGTRDFSNPSTRRTRSTRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAETDRKTRAPENYFYRLLKLNSPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDYDSMERKTKEYVFIYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEHNSSLIAARLATDAADVKSAIAERISVILQNMTSLLTSFIVAFIVEWRVSLLILGTFPLLVLANFAQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELRVPQKRSLYRSQTSGFLFGLSQLALYGSEALILWYGAHLVSKGVSTFSKVIKVFVVLVITANSVAETVSLAPEIIRGGEAVGSVFSVLDRQTRIDPDDADADPVETIRGDIEFRHVDFAYPSRPDVMVFRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDPLAGKVMIDGKDIRRLNLKSLRLKIGLVQQEPALFAATIFDNIAYGKDGATESEVIDAARAANAHGFISGLPEGYKTPVGERGVQLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVAHRLSTIRGVDCIGVIQDGRIVEQGSHSELVSRPEGAYSRLLQLQTHRI
Protein: Probable polyamine transporter At3g13620 (Q9LHN7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable cell membrane polyamine/proton symporter involved in the polyamine uptake in cells.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein C2-DOMAIN ABA-RELATED 4
- Cationic amino acid transporter 7
- Staphylococcal-like nuclease CAN1
- Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1
- Amino acid permease 2
- Amino acid permease 1
- Cationic amino acid transporter 5
- Auxilin-related protein 2
Sequence:
MAISEASKSSHELPVTTAESSGKKATAKKLTLIPLVFLIYFEVAGGPFGEEPAVQAAGPLLAILGFLIFPFIWSIPEALITAELSTAFPGNGGFVIWAHRAFGSFVGSMMGSLKFLSGVINVASFPVLCVTYLDKLFPVLESGWPRNVCIFASTVVLSFLNYTGLAIVGYAAVVLGLVSLSPFLVMSAMAIPKIKPHRWGSLGTKKKDWNLYFNTLFWNLNFWDNVSTLAGEVDEPQKTFPLALLIAVIFTCVAYLIPLFAVTGAVSVDQSRWENGFHAEAAEMIAGKWLKIWIEIGAVLSSIGLFEAQLSSSAYQLEGMAELGFLPKFFGVRSKWFNTPWVGILISALMSLGLSYMNFTDIISSANFLYTLGMFLEFASFIWLRRKLPQLKRPYRVPLKIPGLVVMCLIPSAFLVLILVFATKIVYLICGVMTIGAIGWYFLINYFRKTKIFEFNEVIDDLDNNVNGEHPKVDDHNS
Protein: Rhodopsin kinase GRK1 (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1) (P28327)
Organism: Bos taurus (Bovine)
Function: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).
Subcellular location: Membrane {ECO:0000269|PubMed:14561760, ECO:0000269|PubMed:1527025, ECO:0000305|PubMed:1730692}; Lipid-anchor {ECO:0000269|PubMed:14561760, ECO:0000305|PubMed:1730692}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9WVL4}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000250|UniProtKB:Q9WVL4}.
Interaction partners:
- Recoverin
- Rhodopsin
- Beta-arrestin-2
- Beta-arrestin-1
- Rhodopsin kinase GRK7
- Neuronal calcium sensor 1
- Guanylyl cyclase-activating protein 1
- GIT ArfGAP 1
- Guanylyl cyclase-activating protein 2
- Retinal guanylyl cyclase 1
Sequence:
MDFGSLETVVANSAFIAARGSFDASSGPASRDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNIQDVGAFSTVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRPDGQMPDDMKGVSGQEAAPSSKSGMCVLS
Protein: Tpcn2 protein (B2RYH7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAAEAQPLLGRDRGGGQAHSGADQELCIDQAVVFIEDAIKYRSIYHRLDAGSLWLYRWYYSNVCQRVLGFTIFLILALAFVEVPSSFTRTADVRYRSQPWQPPCGLTETIEALCLLVFLADLSVKGYLVGQAQLQQNLWLLAYFVVLVVSVVDWIVSLSLNCEESLRVRRLLRPFFLLQNSSMMKKTLKSIRWSLPEMASVGLLLTIHLCLFTVIGMLLFTIAEKDEAQNKERLTYFRNLPEALTSLLVLLTTSNNPDVMIPAYTQNRAYALFFIIFTLIGSLFLMNLLTAIIYNQFRGYLMKSLQTSLFRRRLGARAAYEVLTLQAGPNGTTSELVGVNPENFLRVLQKTQLNKIHKQAIIQKVHSYEGRPILADEFQKLFDEVDKGIVKERPPKPQYQSPFLQTAQFIFSHRYFDYLGNLIALGNLLSICVFLVLDSNLLPGERNDFVLGILNYIFILYYLLELLFKVFALGLRGYLFYHSNVFDGLLTIILLVLEISTLAVYRLPHPGWYVIAENLGTQPGQ
Protein: Protein LSO2 (Late-annotated small open reading frame 2) (Q3E772)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Ribosome-associated protein required for translational recovery after starvation from stationary phase. May facilitate rapid translation reactivation by stabilizing the recycling-competent state of inactive ribosomes.
Subcellular location: Nucleus {ECO:0000269|PubMed:26450372}. Cytoplasm {ECO:0000269|PubMed:26450372}. Note=Under iron-replete conditions, enriched in the nucleus. Under iron-depleted conditions, expressed in both nucleus and cytoplasm. {ECO:0000269|PubMed:26450372}.
Interaction partners:
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein uL5A
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein eS27A
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL20A
Sequence:
MGKRFSESAAKKAAGLARKRDQAHAKQRAQMEQLEAEEASKWEQGSRKENAKKLEEEQKRQEKARAKKERDALLTAEEEQLGKGGKGKRKMK
Protein: SUMO-conjugating enzyme UBC9-A (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9-A) (SUMO-protein ligase A) (Ubiquitin carrier protein 9-A) (Ubiquitin carrier protein I-A) (Ubiquitin-conjugating enzyme E2 I-A) (Ubiquitin-protein ligase I-A) (Q9W6H5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Small ubiquitin-related modifier 1
- Small ubiquitin-related modifier
- SUMO-activating enzyme subunit 2
- SUMO-activating enzyme subunit 1
- Si:ch1073-55a19.2.
- Small ubiquitin-related modifier 2
- Small ubiquitin-related modifier 3-like
- Small ubiquitin-related modifier
- Ran GTPase-activating protein 1
- E3 SUMO-protein ligase PIAS4-A
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPMKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFSPS
Protein: Transcription factor bHLH153 (BHLH transcription factor alpha) (bHLH alpha) (Basic helix-loop-helix protein 153) (AtbHLH153) (bHLH 153) (bHLH transcription factor bHLH153) (Q7XJU2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor bHLH137
- Transcription factor bHLH155
- Neutral ceramidase 3
- Transcription factor RAX2
- Transcription factor bHLH36
- Neutral ceramidase 1
Sequence:
MEFSRDAGMMMENKRNVCSLGESSIKRHKSDLSFSSKERKDKVGERISALQQIVSPYGKTDTASVLLDAMHYIEFLHEQVKVLSAPYLQTVPDATQEELEQYSLRNRGLCLVPMENTVGVAQSNGADIWAPVKTPLSPAFSVTSQSPFR
Protein: Mitogen-activated protein kinase (EC 2.7.11.24) (Q0H1F4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MASNKMDETNNSHTAGEASEGDSRRESNIEKVQQRGVTEGPAQPSNDTSTVTDDTTVADKNLALLKAHSLDVKFEVGDEYDIIETIGTGAYGVVSSARRRDNGQQVAIKKIPNAFEVVTNAKRTLRELKILKHFKHDNIIAIKDILQPVVPHSAFKSVYVVLDLMESDLHQIIHSRQPLTPEHTRYFLYQLLRGLKYIHSANVIHRDLKPSNLLVNENCELKIGDFGMARGLSAVYSEESRSFMTEYVATRWYRAPELMLSLHHYSLAIDLWSVGCIFGEMLGRRQMFPGKNYVHQLQLILSVLGTPPESIVGSIGSDRVRSYVRSLPSKAPEPLAALYPQAEPSALNLLAAMLRFDPRERISACQALEHPYLSKYHDPDDEPVCVPAFNFEFDRQPMGKEQIKEAILTEIQDFHKKKQGVRKKIQFKPLHSSGSALSVSCQDVDMPSANSDGQPETIDLTTPTDKDTSFTEPAIDCRKDKSVLSNYTAPSRSVSQTPPTSLPQSVPSLSLSQSQVQSLSQNLSRSLGKGGKPTAAEGTKKEGAISEDTKAALKAALQKSALRQKARDEGTAALGIDLVRGASVGLSSSISSSNSCPEQRRPITAQERQREREEKRKKRQERAMERKRKLKEKEKKEGKHGESLGGVLLSDNDKMLLQRWVRMMDKPADKSQGIETSNAKTSDSNMAQIQPATGNNIIKTNSNGGESVLPKQPNKAQVFKPPQLVSQMGQQPPGAAVQPCLSLTDTGQSSNSIPDIHTVTQQLSKSQVEDILPPVFSVTPKGSGAGYGVGFDLDDLLTQSLTELQHSDLRESHNDLAPLSASLLSDWLEVHRMTPADMESLQQELQLGSPMILSDNSTLPDT
Protein: ZZ-type domain-containing protein (Q17746)
Organism: Caenorhabditis elegans
Interaction partners:
- Probable voltage-dependent anion-selective channel
- Transmembrane GTPase fzo-1
- Glutaminyl-peptide cyclotransferase
- Transcription termination factor 3
- Protein lgg-2
Sequence:
MIPLCREHNKTCRVKVNYHWRVYNEDINKNAVLELSCQCQVLDQLRKTFVELGSSTIHSAADFEFSCITKDGPVVLSSGYEIYNNIRPELSFYHSQLPQLFLHVRILDVSVIAKLDDLGRTVNECKATMKSDKAWRVMKDTEIAEGQLSLQELLDKQQLEIKSLQKDISEMKLENQCRKKEDKNSFKNKEVHEASCDKCQDLIIGHRFKCAICYNYDLCETCEAAGVHAQHALIRLVSENTLFPEHLIVKNPEEVKDQNGQVQAIASSRDRAIQVPLRRLGITPQAIATKNNVSRYLNAQSDRNIIEDPWYAQHMSSRKPQTYERMHPKLKDTTDGKKVQKVSFRDRFYKKAESSLDKHEKQLRFDLSASRQEFIREKEKFRVEKETLMKQKEQIEEMMKQETINFETNRAFFSDRFEPIFNKVKDGKKSEDDTTRKVEFEVETAESNYPGSIFSDEDSLSDLAEILKDIEEYECSSESSDDQEKDDFDVVEEEAKQS
Protein: Uncharacterized protein, isoform A (M9PEK7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Interaction partners:
Sequence:
MNKKDVSPSGSTVPATSVRTGFLRRRNVVEAGSEPSTSQQAEIAIASGKVKKRGILLARKDVEIESGVEVLEDMIPSTAVHIDHSKDVANKRAEEVTDAGADADSRASLTLPVAPGFSTLASSYVEKESGVRDTRSRISFFSNLSMLSVSQWREKHQGATAFALPVLLSVLLILLMILPVPDFLRGVFATLLFFTVMDCCGGHLRALLEDFMLTTHPERVAFAIPNYKFMPICEIPAVEEHKTIKTYAGWMNEINSYDPNTFSFSLTRAVYVRLDGSILKMSGTNARIPKRRMWNEPPIDRHKIPFTDHRSYDLRDCRIELLPLGLANKRFFNRKYPIQLIIKSNRDVPDEQSSVESQSEATVKTDAKEAKAASSSGTTPPGGEEEKLVDFAGTVMQADLQQLRNTVNPDKELNDITVPCGDEVRLLLFSRCDREKEDWYRRFTNASRGLVHEQDLQVPMARFVEDSDLQAAAARQALLLVTGMGKAGVKSEDEISAGKGNDETDQQTPDGQFETITEEDLLDTPKEESFDGMIMSANVARNSPDYVRFMAVYQSRRAKRQEDELWKGIDQSLFLGPSGSIVWANVLLGRCLYSWLHDAMLHEKLKEVLQKKLNSIKLPSFMEEVIITNIYLGESPLLCHRVSQPMLDERGVWIDADVTYEGLAHITVTTKLNLLRIRSKTKSPMATDNVPTTSMLPEQSQDLRSLSEVNSENVIYDSDAESSGGSSTESESPPPGNAPENAAGTEFFQNSPGNARRIFKIVDRIAASNLFQYATELPYVQRAMENMNANITLRVDLKGLVARGTLNVPPPPSDRVWVSFRGPPRLWISTKPQVGDKSVDWSIVTNVIESKLCEAVNKFLVYPNMVDFSIPFLSNPNFDEDQGNAAN
Protein: DNA-binding response regulator (A7MXJ7)
Organism: Vibrio campbellii (strain ATCC BAA-1116)
Interaction partners:
Sequence:
MDSTYTIIIADDHPLFRNALFQSVHMAVSGANLLEADTLDALLALLEKEEEPDLVLLDLKMPGANGMSGLIHLRAEYPDIPVVVVSASEESSVVTQVKSHGAFGFIPKSSDMRELVNALNQVLNGDPYFPEGLITNNAACNDLAEKIAALTPQQYKVLGMLSDGLLNKQIAYELNVSEATIKAHMTAIFRKLGVKNRTQAVILLQQMEPEQ
Protein: Neurexin-3-beta (E9P876)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MVTGPAWRTNKSLTTTATTEASSTKSNRKTTTTTTTSATTTIRIQQRPNYDIDNEVTALITSSLAPQKTRPKSTPHFTVYPVRPTTPMGDTITTTMQAATVTDFPRTPLIMCSSLAVIIAIAAVVFFVFKCRQNPPNSEHYTMAMKSQSGYTAIAPELSPPMNHDRSNDSCTQPLLAKPHINGNGYEPLKGAVIANGNGATATMMRNGNGNGVAKKKDFKEWYV
Protein: Insulin-degrading enzyme (EC 3.4.24.56) (Insulin protease) (Insulinase) (Insulysin) (P22817)
Organism: Drosophila melanogaster (Fruit fly)
Function: Can cleave insulin and TGF-alpha.
Interaction partners:
- FI12805p
- GH26575p
- Neprilysin-4
- Neprilysin-like 20
- Neprilysin-1
- Neprilysin-2
- Neprilysin-3
- Presenilin homolog
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MTIAESSQKSATRKPDSMEPILRLNNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFIPTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYKLLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVEITNMERHKPISDIVTFKSCKELYPIALPFLDIKAKGARSKL
Protein: Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form] (Q9ESE2)
Organism: Rattus norvegicus (Rat)
Function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted {ECO:0000250}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 11B
- TNF receptor superfamily member 11A
- TNF receptor-associated factor 6
- Sclerostin
- Macrophage colony-stimulating factor 1 receptor
- Cathepsin K
- Osteocalcin
- Nuclear factor of activated T-cells 1
- Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a.
- Runt-related transcription factor 2
Sequence:
MRRANRDYGKYLRGSEEMGSCPGVPHEGPLHPAPSAPAPAPPPAASRFMFLALLGLGLGQVVCSIALFLYFRAQMDPNRISEDSTRCFYRILRLRENTGLQDSTLESEDTEALPDSCRRMKQAFQGAVQRELQHIVGPQRFSGVPAMMEGSWLDVARRGKPEAQPFAHLTINAADIPSGSHKVSLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSVPADYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSINVGGFFKLRAGEEISVQVSNPSLLDPDQDATYFGAFKVQDID
Protein: Heat shock protein DNAJ homologue Pfj4 (Q7KQK3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Heat shock protein 110
- Endoplasmic reticulum chaperone GRP170
- Heat shock 70 kDa protein
- Heat shock 70 kDa protein
- Endoplasmic reticulum chaperone BIP
- Heat shock protein 70
- Thioredoxin-like protein
- Glideosome-associated connector
- Ras-related protein Rab-2
Sequence:
MSRRVNYYEVLGVPQDADLTVIKKSYRTLAMKWHPDKNPNNKAEATERFKQISEAYEVLSDPKRRRKYDLYGTDENYMADENDEFSNFHKNFGFNDAQRIFEMFFGDSSPFGNDSFFSDVMGSSFVDKRRGRVPRSNDPFDNFFGSSFNVSFGSSFDNFMDGGSCFTSVETSTSNGGKFKNRVVKTSTSKSTSIINGKRVTRIETVKTLPNGTVERTVTEREEDDRGNINIRQLPAHELRRNKR