wanglab/gogpt-training-data huggingface dataset:
Protein: Diaminopimelate decarboxylase 1, chloroplastic (DAP decarboxylase 1) (DAPDC 1) (EC 4.1.1.20) (Q949X7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Diaminopimelate epimerase, chloroplastic
- Alpha-aminoadipic semialdehyde synthase
- aspartate-semialdehyde dehydrogenase
- Diaminopimelate decarboxylase 2, chloroplastic
- LL-diaminopimelate aminotransferase, chloroplastic
- 4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic
- 4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic
- Arginase 2, chloroplastic/mitochondrial
- Aspartokinase 2, chloroplastic
- Aspartokinase 1, chloroplastic
Sequence:
MAAATQFLSQPSSLNPHQLKNQTSQRSRSIPVLSLKSTLKPLKRLSVKAAVVSQNSSKTVTKFDHCFKKSSDGFLYCEGTKVEDIMESVERRPFYLYSKPQITRNLEAYKEALEGVSSVIGYAIKANNNLKILEHLRSLGCGAVLVSGNELRLALRAGFDPTKCIFNGNGKSLEDLVLAAQEGVFVNVDSEFDLNNIVEASRISGKQVNVLLRINPDVDPQVHPYVATGNKNSKFGIRNEKLQWFLDQVKAHPKELKLVGAHCHLGSTITKVDIFRDAAVLMIEYIDEIRRQGFEVSYLNIGGGLGIDYYHAGAVLPTPMDLINTVRELVLSRDLNLIIEPGRSLIANTCCFVNHVTGVKTNGTKNFIVIDGSMAELIRPSLYDAYQHIELVSPPPAEAEVTKFDVVGPVCESADFLGKDRELPTPPQGAGLVVHDAGAYCMSMASTYNLKMRPPEYWVEEDGSITKIRHAETFDDHLRFFEGL
Protein: Pom152p (A0A1D8PG44)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Utp8p
- FG-nucleoporin
- Nucleoporin NDC1
- Uncharacterized protein
- Nuclear pore protein
- Nucleoporin NUP188
- Cysteine synthase 1
- Uncharacterized protein
- Purine nucleoside permease
Sequence:
MDSTDTEIRRKRNRESSSQPLIPTSVLDQASQRLFIVSIFILIQSWKIYDLVLLKSEIPATGEVLTSLSNFTFVLKYSVLDGLFLWLLPVLNIQYLSFSPLKTLLLTITLYGFSIFLVSAMALPLLSNVFLPIWRFLLQKKELNIIGESIDRSQVIDMDSHFKGQLTIHYLPDSSAKMNPFHFDQTCLGLDNNHLINMPVEFNTTSGIGYLQVQHTTPDNEIQYLNYTGHFLRRLFKKDYTHLSQYKDYKKSDKRIFYLEYPITKPGMYRIKNVLDNKGNSIRTYKSEFVISDCPSAKFFYPPNFESSNGFKCVTTLEDDSFPLPWVEVSSTTPSSVKLNVKVNGKEFRMMNLTIGQETDHKVSRTDFSWLKTVRLVRNSLQEKILDSKSTFNWGDTSILEFQLLQVKDSFGNVHRYEPLSKDKDVWYKLELRKSPSIGIYDKEKTQELLVGGQKVLYFSNLENFNDDDFPIDVKVKYIGQEEQNITRTFETKADLRNGLTITKPGKYVLSSAKDKYCPCEADKTPVEVELASIPSLDIVADPVSDRCLGTIGYNFDFNFTEGRPPFRVQYRIYSNTSGILKPVYSDTGKLNRELKSFEKSHSFKFKPPNEGSYTIMFTNLKDANYFKDPIALDENKYSYSTYFRQLSQVGFQVHQRTIHTCYGHTTKVPIFFNGNGPFSFEYDFLDVNSRKKLVDTVRVSNVENYAIDTPKELIGKTYDLKLSNAKDRFGCDAIIVDANSPVRVVSRSDIPEVEFSRAGQKLQVVEGSYVDIPLSIKSKIAVNGNDKIEVKYLGPTSKEPTIRRAQLVGSSIRLSDEGTYWLHSFESNGCAGRIGKADQFVTIGYYAKPSLAISASNEMLQHTDDSTIHLKPVCNGCSNEITLKLTGEAPFVVDYEINLPSGKMETHSMNIDTHDITIKLPTRSNGRFEHQFKRVYDRLYTKTRGKPTSLHVPKVIYDINPLPTAQFLPDDHFTQVCENKLSEDSVIAHVPIQFSGAYPFDVLLTLTNEKTGKMHDIRYRNVEDNYITLKTLNFLGLGDYSLKFAKVSDANGCTTHQFKTNDRYLISITEPPTIYKADPATKHYCVGDHVAYNLSGVFPITIFYEYNDKVRRVESYSRFERLASRPGVLNIHGLKDSGINSCAVNYTFDTTKLDELRLEVHEIPTVEVNKGDYLIEDLHEGDQTELIFTFLGEPPFQLTYIRTIDIRKGKKTFRKLVEKETIKDIWQHELVVMASLEGTYEAIEIQDKYCRAVKKVDYIE
Protein: Probable oxidoreductase (O65936)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- GFO/IDH/MocA-like oxidoreductase domain-containing protein
Sequence:
MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMGETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTTMRLLDELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLHQPYPYVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEGPGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPREGDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEFRRDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTAVTQAVQRVLHRRLLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFVGVGVRPEHAPAFARRGPGNRKGP
Protein: TM2 domain-containing protein 1 (Amyloid-beta-binding protein) (hBBP) (Q9BX74)
Organism: Homo sapiens (Human)
Function: May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.
Subcellular location: Membrane {ECO:0000269|PubMed:11278849}; Multi-pass membrane protein {ECO:0000269|PubMed:11278849}.
Interaction partners:
- TM2 domain-containing protein 2
Sequence:
MAAAWPSGPSAPEAVTARLVGVLWFVSVTTGPWGAVATSAGGEESLKCEDLKVGQYICKDPKINDATQEPVNCTNYTAHVSCFPAPNITCKDSSGNETHFTGNEVGFFKPISCRNVNGYSYKVAVALSLFLGWLGADRFYLGYPALGLLKFCTVGFCGIGSLIDFILISMQIVGPSDGSSYIIDYYGTRLTRLSITNETFRKTQLYP
Protein: Thyroid peroxidase (TPO) (EC 1.11.1.8) (P07202)
Organism: Homo sapiens (Human)
Function: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Subcellular location: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell surface.
Interaction partners:
- Thyroglobulin
- Thyrotropin receptor
- Tyrosinase
- Sodium/iodide cotransporter
- Tyrosine 3-monooxygenase
- Aromatic-L-amino-acid decarboxylase
- F-box-like/WD repeat-containing protein TBL1X
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Putative aspartate aminotransferase, cytoplasmic 2
Sequence:
MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQAVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
Protein: ENA (A0A384KR51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAVNACLSPPEMMAVRPGEGVPNSKSTQGKTRLYLTKPSWIVRTQSGAKTCMKSKAKGRCVICHGSGRVDCFNCCGKGRTNCVDVEMLPRGEWPKWCKSCGGSGLSDCSRCLGTGEYRYIMGFRFLNQNDDADPQ
Protein: FI22161p1 (Q9V3I9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cyclin-K
- RE70879p
- Not1, isoform H
- poly
- CCR4-NOT transcription complex subunit 3
- Regulator of gene activity
- CCR4-NOT transcription complex subunit 4
- CCR4-NOT transcription complex subunit 11
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 9
Sequence:
MKRHYYNTGDDQQEVESSPSPPPPPPFQSPLSSPESLQTPDGYPILYVDVVKNKPKQELPPSASPSQPLAPEFSIFREDFPALPGSLPSALPTALPTTSSPVVPDDWTAMMSNSEQVELAKFRNTVIRNSSDPCVNANGNEVLRQPTHAPEKRQNMELLPHMYGYLGNPFRLNLSMIFTKQFLLEGVRQRAINAAHKRAALAKPAIQPPPGFENCKIFARLITNSDGMPLGGVTFELGSPTNETTSNVEAKPSGSTIQGAFGMLGLAKKLRSINQNPLLFGNNVAHNIGGAADSIFTGPIQEARLTPQEMSYKLPLNYLFNVNMSLQEPKIEEMHDELLFFFFYTYAGDMMQMLAAAELAERGWRYHKYEHFWVIRQADNPNYLYHGFREFGEYNYFNMWQWKILPRHFYLDPEILERTLSKEELYVTYGYHPQMSGI
Protein: Protein FRA10AC1 (Q70Z53)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:15203205, ECO:0000269|PubMed:34694367}.
Interaction partners:
- Zinc finger protein 32
- Spliceosome-associated protein CWC27 homolog
- Splicing factor ESS-2 homolog
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
- Calcium homeostasis endoplasmic reticulum protein
- Leucine-rich glioma-inactivated protein 1
- Splicing factor 3B subunit 2
- Protein Red
Sequence:
MHGHGGYDSDFSDDERCGESSKRKKRTVEDDLLLQKPFQKEKHGKVAHKQVAAELLDREEARNRRFHLIAMDAYQRHTKFVNDYILYYGGKKEDFKRLGENDKTDLDVIRENHRFLWNEEDEMDMTWEKRLAKKYYDKLFKEYCIADLSKYKENKFGFRWRVEKEVISGKGQFFCGNKYCDKKEGLKSWEVNFGYIEHGEKRNALVKLRLCQECSIKLNFHHRRKEIKSKKRKDKTKKDCEESSHKKSRLSSAEEASKKKDKGHSSSKKSEDSLLRNSDEEESASESELWKGPLPETDEKSQEEEFDEYFQDLFL
Protein: Putative zinc finger protein 702 (Q9H963)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MREKSFQCNESGKAFNCSSLLKKCQIIHLGEKKYKCDICGKVFNQKRYLAYHHRCHTGEKPYKCNQCGKTFSYKSSLVIHKAIHTGEKPHKCNECGKVFNQKAYLASHHRLHTGEKPYKCEECDKVFSR
Protein: Uncharacterized protein (Q585C7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Mitochondrial RNA binding protein
- Guide RNA binding protein
- HTH OST-type domain-containing protein
- Treble clef zinc finger domain-containing protein
Sequence:
MRRCATRLLSFQQLLCGSEFVPDDAAAVQKVASAFREKYPVAPLPVPIAAGLGRSYLLQREPRRVVALLSSHPSAREVGTQLMQLLSSKNGIEAKTLLQLADALRPVSVGMCCELLCALAEKVAKTDYAREVKQMLMREIREVPHLSGTLINSLCLLSDHTLAEDRQNVVDAFNIALRKSFVSPRDYGAVLLFLARGGDHRKVLTLWLWMSHSSARWDQTAASAVIISASLTRKMNTAIDAIHCLAEANLDPTVEAQRRFIRFLAYRVPPLAAYAEQLVTHWHTPQQLWTTDARLVGVELLYTHYHAKNYEHLQGCLQVADASIEEAGRMAERSDNKESTDELRHKILRITGMPYILRHFSLDIADEPWLQNFYRSGMRMKDLGDYPLLLGVMASFARHMKEEEKFLEDIRNIKMSPENFEVTSTFIAEDKCFRNAEDTLHFVNCMGDVFSMEVPKGVVNWLELLSEK
Protein: MotA/TolQ/ExbB proton channel family protein (B7JA62)
Organism: Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270))
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU004057}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU004057}.
Interaction partners:
- Biopolymer transport protein, ExbD/TolR family
- TonB family protein
- Biopolymer transport protein, ExbD/TolR family
- Biopolymer transport protein, ExbD/TolR family
- Biopolymer transport protein, ExbD/TolR family
- Biopolymer transport protein, ExbD/TolR family
- Biopolymer transport protein, ExbD/TolR family
- Uncharacterized protein
- Iron compound ABC transporter, ATP-binding protein, putative
- Iron compound ABC transporter, periplasmic iron-binding protein, putative
Sequence:
MEILLHLAAVSGGILYLMPLLLLVVLFVALERGWALAMIRRKGDDLLRDLQDRKGRESLETELAKTPSCPQQAVFAAVLASHDLASGEAYAEEAMLTQATLLDRGLWILDTAVTLAPLLGLLGTIIGMFNAFQILGNPDTAPTAITGHVAEALVATATGLAIAIVGLVLFNGLQQRVRLVLHQMERIKVSTLNRLYRQPPSIRGDASVSLLARRGEI
Protein: Phosphatidylinositol 4-kinase gamma 3 (AtPI4Kgamma3) (PI-4Kgamma3) (PI4K gamma 3) (EC 2.7.1.67) (Q9FNF8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Interaction partners:
- E3 ubiquitin-protein ligase UPL4
- Protein NBR1 homolog
- E3 ubiquitin-protein ligase PRT1
- E3 ubiquitin-protein ligase UPL3
- Transmembrane protein
- E3 ubiquitin-protein ligase UPL5
- Eukaryotic aspartyl protease family protein
- 1-phosphatidylinositol 4-kinase
- Expressed protein
- Transmembrane protein
Sequence:
MSVASVALSPALEELVNFPGIIGRFGFNLDDPILVFLTIAGSVIPKRVMESDSIASVKLRIQSIKGFFVKKQKLLYDGREVSRNDSQIRDYGLADGKLLHLVIRLSDLQAISVRTVDGKEFELVVERSRNVGYVKQQIASKEKELGIPRDHELTLDGEELDDQRLITDLCQNGDNVIHLLISKSAKVRAKPVGKDFEVFIEDVNHKHNVDGRRGKNISSEAKPKEFFVEPFIVNPEIKLPILLKELISSTLEGLEKGNGPIRSSDGSGGAYFMQDPSGHKYVSVFKPIDEEPMAVNNPHGQPVSVDGEGLKKGTQVGEGAIREVAAYILDYPMTGPRTFPHDQTGFAGVPPTTMVKCLHKDFNHPNGYSFSPENTKIGSLQMFVSNVGSCEDMGYRVFPVDQVHKISVLDIRLANADRHAGNILVSRDGKDGQMVLTPIDHGYCFPNKFEDCTFEWLYWPQAKEPYSSETLEYIKSLDPEKDIELLRFHGWEIPPSCTRVLRISTMLLKKGSAKGLTPFTIGSIMCRETLKEESVIEQIIHDAEAIVPTETTEDEFISTVSAIMDNRLDQYAWN
Protein: Protein phosphatase 2C homolog C10F6.17c (EC 3.1.3.16) (Pyruvate dehydrogenase (Lipoamide) phosphatase C10F6.17c) (O14189)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in regulation of pyruvate dehydrogenase activity.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MNFFTSAVGSKVFKRNNFKYVAIAASSIGLAAYHIRKDAIALDIPNSTYQHVSKNRVPPTDGDGITKRLKEFERTVTVNKDGIFRYDFNQVASNDPCEDDHVEVIDRNIDEGNWYFWGIFDGHSGWNTSLFLRQHLVPAVVRELQKCTASYYHQNACPSSLALDKSISEAFAKVDHQIVHEHVSHVFNNPESLQVAASLLLPALSGSCALLTSYSAKSKSLQVACTGDSRAVLGECTPDGSWEAIPLSRDQTGMNPDEASRLEVEHPGEEVLRNNRILGRLMPSRAFGDARYKWSQEISERLHREYFSASPIPVKTPPYVTAVPEIESITVNPKKHRFLIMASDGLWDTMSSEQAVQLVGEWADTVLGKTTNEKNTTQDDKQSWSLFKKTSKVIDDNAATHLIRHSLGGSDQRISALLTLTYPISRRYRDDITVTVIFFDEKTL
Protein: Transcriptional regulatory protein HprR (Hydrogen peroxide response regulator) (P76340)
Organism: Escherichia coli (strain K12)
Function: Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Sensor histidine kinase HprS
- Sensor histidine kinase CusS
- 5-hydroxyisourate hydrolase
- Sensor protein BasS
- Signal transduction histidine-protein kinase BaeS
- Sensor histidine kinase CpxA
- Transcriptional regulatory protein BtsR
Sequence:
MKILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAKQTPVICLTARDSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALNSTLEISGLRMDSVSHSVSRDNISITLTRKEFQLLWLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVDDPFPEKLIATIRGMGYSFVAVKK
Protein: Isopentenyl phosphate kinase (AtIPK) (IPK) (EC 2.7.4.26) (Q8H1F7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the formation of isopentenyl diphosphate (IPP), the universal five-carbon isoprenoid building block of all natural isoprenoids. Acts in parallel with the mevalonate (MVA) pathway and plays an important role in regulating the formation of both MVA and methylerythritol phosphate (MEP) pathway-derived terpenoid compounds by controlling the ratio of isopentenyl phosphate (IP) and dimethylallyl phosphate (DMAP) to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Controls the levels of IP and DMAP that are competitive inhibitors of the farnesyl diphosphate synthase. Regulates the production of farnesyl diphosphate-derived terpenoids in the cytosol, and geranyl diphosphate-derived compounds in plastids.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:26216978}.
Interaction partners:
- Isopentenyl-diphosphate Delta-isomerase I, chloroplastic
- Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial)
- Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 1, chloroplastic
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- Diphosphomevalonate decarboxylase MVD2, peroxisomal
- Diphosphomevalonate decarboxylase MVD1, peroxisomal
- Farnesyl pyrophosphate synthase 2
- Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 2
- Isopentenyl-diphosphate Delta-isomerase II, chloroplastic
- Farnesyl pyrophosphate synthase 1, mitochondrial
Sequence:
MELNISESRSRSIRCIVKLGGAAITCKNELEKIHDENLEVVACQLRQAMLEGSAPSKVIGMDWSKRPGSSEISCDVDDIGDQKSSEFSKFVVVHGAGSFGHFQASRSGVHKGGLEKPIVKAGFVATRISVTNLNLEIVRALAREGIPTIGMSPFSCGWSTSKRDVASADLATVAKTIDSGFVPVLHGDAVLDNILGCTILSGDVIIRHLADHLKPEYVVFLTDVLGVYDRPPSPSEPDAVLLKEIAVGEDGSWKVVNPLLEHTDKKVDYSVAAHDTTGGMETKISEAAMIAKLGVDVYIVKAATTHSQRALNGDLRDSVPEDWLGTIIRFSK
Protein: Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) (Q9Z2D6)
Organism: Mus musculus (Mouse)
Function: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Subcellular location: Nucleus {ECO:0000269|PubMed:15034150, ECO:0000269|PubMed:17296936}. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. {ECO:0000250|UniProtKB:P51608}.
Interaction partners:
- Paired amphipathic helix protein Sin3a
- Histone deacetylase 1
- Histone deacetylase 2
- Cyclic AMP-responsive element-binding protein 1
- DNA
- Nuclear receptor corepressor 1
- Delta
- Histone-lysine N-methyltransferase SUV39H1
- Nuclear receptor corepressor 2
- REST corepressor 2
Sequence:
MVAGMLGLREEKSEDQDLQGLRDKPLKFKKAKKDKKEDKEGKHEPLQPSAHHSAEPAEAGKAETSESSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTGRPKAAASEGVQVKRVLEKSPGKLVVKMPFQASPGGKGEGGGATTSAQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVHETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHSESTKAPMPLLPSPPPPEPESSEDPISPPEPQDLSSSICKEEKMPRGGSLESDGCPKEPAKTQPMVATTTTVAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS
Protein: Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Q18965)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Interaction partners:
- Transmembrane GTPase fzo-1
- FIS1-related protein fis-1
- Serine/threonine-protein kinase pink-1, mitochondrial
- FIS1-related protein fis-2
- E3 ubiquitin-protein ligase parkin
- Mitoferrin
- MICOS complex subunit MIC60-1
- Mitochondrial fission factor
- MICOS complex subunit MIC60-2
- Mitochondrial fission factor
Sequence:
MRIATRRRFISNNLHKFSRISASTSATLAAYSNGNQHQNRQFGTNALFSKKGGLLQKRQTVINLQSERAFIGIAASAARHLLKLRYFIATGVIGGSVAARTWYEEWKSNLPDLSLPEWFDSNGSWNEFSQKMKGIKDGFGADGQNKWAEWMAKFEQFKQQKEDQNGNSGGGGGGEGNVPVKEPVILASLMSAFSSKKDEPEEKKDNVSAEERIQKLQEEMLKTQSQYQRELERLEKENKVLKQRLLLSDDKAAIRLKRLKRSLIDMYSEVLDLLNEYDSSYNTSDNLPRVVVVGDQSAGKTSVLEMVAQARIFPRGSGEMMTRAPVKVTLSEGPYHVAQFRDSSREFDLTKETDLQQLRNETEVRMRNSVRDGKTVSNEVISLTVKGPNLPRMVLVDLPGVISTVTADMARETKDDIIRMSKAHMENPNAIILCIQDGSVDAERSNVTDLVSSIDPSGKRTILVLTKVDMAEKNLANPDRIKKILEGKLFPMKALGYFGVVTGRGNSSDSIDEIRKYEENFFSTSQLLRDGVLKPSQMTTRNMSLAVSDCFWRMVRDSIESQTDAFRAAKFNLEAEWKNHFLRIRQLNRDELYDKARGEILDEIVNLSLIGVEEWEKLLQDKLWSGISSHVFDQILMPAYASSSSGSFNTTVDIKLKHFADKQLAQKSIETGWDTLKEVFFRQINQDARTKKDHDPVFDALKEAVIEEAMLTHGWDDKAMDYLRVIQLNAMEDRAVQDKRSWDAACNFLHKAASERLAAVKKQLTDDRGPGWASKWLMWKTPTADNHYSCVIQDELYSILGADPEHKQALTDDDITVIRRNIETKGVLEVPTESIRKQWKLVFKKHFLERIINSSKDCLSMYQMYRQGMIEGQDIDCQTIVLFYRIQKMVNLTCNALRQQITNTEHRRLEKEIKEVLDDWSQEPDIKKKYLTGRRVDLAEEIQQVRRIQEKLEEFMAQLQREKI
Protein: Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC) (Q9P3T8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Tubulin-folding protein; involved in the final step of the tubulin folding pathway.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Cell polarity protein alp21
- Tubulin-folding cofactor D
- Cell polarity protein alp11
- ADP-ribosylation factor-like protein alp41
- Small ribosomal subunit protein mS38
Sequence:
MSEKFVELRKEFLTKLYKSTPSEQTSRSEKETWLEEKSKYLGEMTRELNEVQDQIAPYDRRVCMEQLVDLTRRLQQIRHDILPRQPFRFQRALHVKSSQKPVKNITVNAEAPEVYFENDTLYLANLKNQNIGDNVIPYPNNKAVKVSAKSLRSCNISISNCSSVNLHNATKCNFTFPTIQGSIHLSDINDSTICVSCHQFRLHHSTNLRVHLRCKTSPVIEESKEISFSYKDEHPILDFTWARSDPSPHFRITSDLFDA
Protein: Olfactory receptor class A-like protein 1 (Vomeronasal type-1 receptor-like protein) (A0A0R4IM31)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable pheromone receptor. Shows high specificity for 4-hydroxyphenylacetic acid. Activation of the receptor stimulates intracellular calcium release.
Subcellular location: Cell membrane {ECO:0000255|RuleBase:RU364061, ECO:0000269|PubMed:24831010}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU364061}.
Interaction partners:
- Olfactory receptor class A-like protein 4
- Taste receptor type 2
- Olfactory receptor class A-related 5.
- General transcription factor IIF subunit 2
- Uncharacterized protein.
- Olfactory receptor C family, r1.
Sequence:
MDLCVTIKGVSFLLQAGLGILANALVLLAYAHIRLAEARLQPVDAILCHLALVDLLLLLTRGVPQTMTVFGMRNLLDDTGCKVVIYTYRIARALSVCITCMLSVFQAVTVAPAAGPLLSGVKARLPQLLAPTFAALWFINMAVCIAAPFFSVAPRNGTVPPFTLNLGFCHVDFHDNLSYVLNGVAVSVRDFAFVGAMLASSGFILLLLHRHRRQVRAVRRSQGSTMETRAARTVLMLVILYSVFFGIDNVIWIYMLTVAQVPPVVADMRVFFSSCYASLSPFLIISSNRKLKARMVCATSEQERQAEDGKNSSGKN
Protein: Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5) (Q16352)
Organism: Homo sapiens (Human)
Function: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity).
Interaction partners:
- Neurofilament medium polypeptide
- Neurofilament heavy polypeptide
- Neurofilament light polypeptide
- Gigaxonin
- Protein TANC1
- Vimentin
- Glial fibrillary acidic protein
- Nestin
- Disks large-associated protein 1
Sequence:
MSFGSEHYLCSSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESFEEILEETVISTKKTEKSNIEETTISSQKI
Protein: NADP-specific glutamate dehydrogenase 1 (NADP-GDH 1) (EC 1.4.1.4) (NADP-dependent glutamate dehydrogenase 1) (P07262)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the incorporation of an ammonium ion into alpha-ketoglutarate to form L-glutamate, the major route of assimilation of ammonia into an organic form in yeast.
Interaction partners:
- Glutamate synthase
- Glutamine synthetase
- NADP-specific glutamate dehydrogenase 2
- NAD-specific glutamate dehydrogenase
- Magnesium-activated aldehyde dehydrogenase, cytosolic
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Glutamate decarboxylase
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Alanine aminotransferase, mitochondrial
Sequence:
MSEPEFQQAYEEVVSSLEDSTLFEQHPEYRKVLPIVSVPERIIQFRVTWENDKGEQEVAQGYRVQYNSAKGPYKGGLRFHPSVNLSILKFLGFEQIFKNSLTGLDMGGGKGGLCVDLKGRSNNEIRRICYAFMRELSRHIGQDTDVPAGDIGVGGREIGYLFGAYRSYKNSWEGVLTGKGLNWGGSLIRPEATGYGLVYYTQAMIDYATNGKESFEGKRVTISGSGNVAQYAALKVIELGGTVVSLSDSKGCIISETGITSEQVADISSAKVNFKSLEQIVNEYSTFSENKVQYIAGARPWTHVQKVDIALPCATQNEVSGEEAKALVAQGVKFIAEGSNMGSTPEAIAVFETARSTATGPSEAVWYGPPKAANLGGVAVSGLEMAQNSQRITWTSERVDQELKRIMINCFNECIDYAKKYTKDGKVLPSLVKGANIASFIKVSDAMFDQGDVF