wanglab/gogpt-training-data huggingface dataset:
Protein: Unconventional myosin-XVI (Myosin heavy chain myr 8) (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) (Q9ERC1)
Organism: Rattus norvegicus (Rat)
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11588169}. Note=Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells. {ECO:0000269|PubMed:11588169}.
Interaction partners:
Sequence:
MEIDQCLLESLPLGQRQRLVRRMRCEQIKAYYEREKVFQKQEGLLKRIKPGKSQKVRFGLADMIQDAIIHHHDKEVLQLLKEGADPHTLVSSGGSLLHLCARYDNVFIAEVLIDRGVNVNHQDEDFWAPMHIACACDNPDIVLLLILAGANVLLQDVNGNIPLDYAVEGTESSAILLAYLDENGVDLNSLRQIKLQRPLSMLTDVRHFLSSGGDVNEKNDDGVTLLHMACASGYKEVVLLLLEHGGDLNGMDDGYWTPLHLAAKYGQTTLVKLLLAHQANPHLVNCNGEKPSDIAASESIEEMLLKAEIAWEERMKESPSVPSLAQEELYEEILHDLPELSSKLSPLVLPIAKQDSLLEKDIMFKDTTKGLCNQESQDGPPETSMVSSSSKPEQVQLTPPAPSDDLATLSELNDSSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTVVSQMYLSPTGQRSPSLPPHLFSCAERAFHRLFQERRPQNIILSGERGSGKTQASKQIMKHLTSRASSSCTMFDSRFKHAICILEAFGHAKTTLNNVSSCLIQYWELQFCQRRKHVTGARISTYMLEKPRLVAQPPGQGSFLIFSWLMDGLSAEEKCGLHLSNFCAHRYVSQGMREDVSTAERSLNKERLADLKHALNVIGFSALEVENLFAILSAILHIGDIQFTALTEADSAFVSDLQLLEQVADMLQVSTDELASALTTDIQYFKGDVIIRRHTTQIAAFYRDLLAKSLYSRLFGFLINTVNCCLQSQDEYKSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGVAMETACSPGNQAGVLDFFFQKPSGFFSLLDEESQAIWSVEPNLPRKLQGLLESSNTNAVYSPMKDGNGNVAFKGQGAAFTVMHYAGRVTYEIRGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSPTGSLISSYPSFKFGGHKSSLLSKRIASSMVGVNKNYLELSKLLKKKGTCTFLQRLERGDPATTASQLTKSLADITAKLQKGSPHFILCVKPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRYGYPVRPSFEDFLSRYEPLASVLLGEKKGQPAEERCRLVLQRCKLQGWQMGVHKVFLKYWQVDQLGDLWLQMQRKIVTCQKVIRGFLARQHLLQRMSIKQQEVTSIKSFLQSTEDMALKTYDALVIQNASDIAREHDRLRKEVHAAYHRNRQEEGTKRAEDQGGCRHAHSNSVPVPMAVDSLAQALAGPSSRSPSLHSVFSMDDSTGLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSATKDAASEALTRPRPHSDDYSTMKKIPPRKPKRSPHTKLSGSYEEIWGPRPSGTMGQVGKHHAPGTLGVQWASPDSMPQCTPQLPLHLPLPQGDYDDDGEPVYIEMVGNAARAGGSETDSPDQGESVYEEMKYVLPEEGCGPGMLTFLPASPPLFLETRKAIILEAGEGSCQPLKDTCDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQSEGSSPLSPQYSKAQKGENDQLTSPGFPVFNGPSRISPPATPPPPPGPPPAPCGPPSAPCGPPPAPCGPPPVPCGPPPAPCGPPPAPCGAAPAPCRPPTHFAFPPDSVLVTAAKALTNSDLPRTQPKPSSAPVLGPCSPFVKAPYSPGRTARADLRKASSTFSPPSPYSPPNSRPLSSPLDELASLFNSGRSVLRRSAVGRRIREAEGFETNMNLSSRDEPSSSEMASETQDRNANNHGTQLSSSLSSVVAAENGNPVTNGLAEDDGCSRLCLSGMGTSSFQRHRESHTTQVIHQLRLSENESVALQELLDWRRKLCESREGWQEAMQHPEPRAPPPPPCKKPTLLKKPEGGSCTRLSSQLWDSSI
Protein: Arylsulfatase L (A0A5F9ZHX8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLHLHHSWTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDDPQ
Protein: Retrotransposon hot spot (RHS) protein, putative (Q57UU5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSRANSPAAPQGNNANPQVPNNIEGPMRRPRDENVAPPPAQPPQMPQRYKRFSDWKMNSTVRDFLLEEYATLPKMNLHDFLNQCFSNTYNTVNVSMETFVKNPEDYIKDAEILEDIQDTDEFQLLRADIYLSEEKIFTISDWVNGATPEVKNSISPVARGRLNAVQHAVTESEVWFLPRVSVKSCRDVYDSFYNAKWSYVMSGYDAEPLGMKVFDGRPQRIWTEAELNITPKTADFDARVKEGSNGLEIFVLTSEKGWPYNRFVLGYTERCKTICKHVYIRREIMRVWYIIQRGLKAWWMEATAEGPPIHIIIGTSGIGKTCGLGSFLFYSLLHFNEGMLDVVAYFLEDAAFLIYNREGEERGTVDEYERWESAVAAINKMKFENRGHIIMDTRYAMEKLYTQLPSDVWSVTFLTFPKSAHFDEWSANKGGHQIIMNCDDVRDMKAFMAWKKLSIHTGEKVSNRRRYELKREIEDEWKIVEGRINLIGPLPRYIFGLGCYEWHLKRVYDALRAMKKSDKYCYNDIIEHTADWRNDEVMNKLVKIVRVKGNVGGVESYKCQALSLMIRNMMMN
Protein: H/ACA ribonucleoprotein complex subunit gar1 (snoRNP protein GAR1) (Q06975)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P28007}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit nhp2
- H/ACA ribonucleoprotein complex subunit nop10
- H/ACA ribonucleoprotein complex subunit cbf5
- rRNA 2'-O-methyltransferase fibrillarin
- Protein gar2
- Nucleolar protein 58
- 13 kDa ribonucleoprotein-associated protein
- Nucleolar protein 56
- tRNA pseudouridine synthase 4
- Protein shq1
Sequence:
MSFRGGRGGGFRGGRGGSRPFTPSGPPDQVIELGLFMHDCEGEMVCQSTNVKIPYFNAPIYLENKSQIGKIDEVFGPMNQVYFTVKPSEGIVSSSFKVGDKVYLSGDKLIPLDRFLPKPKTVGPKKPKGARNGPAGRGGRGGFRGGRGGSRGGFGGNSRGGFGGGSRGGFGGGSRGGSRGGFRGGSRGGFRGRF
Protein: Pentatricopeptide repeat-containing protein At5g04810, chloroplastic (Maize PPR4 homolog) (AtPPR4) (Q0WMY5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in the plastid ribosome biogenesis.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18431481}.
Interaction partners:
- Protein THYLAKOID ASSEMBLY 8, chloroplastic
- CRS2-associated factor 2, chloroplastic
- Proteinaceous RNase P 1, chloroplastic/mitochondrial
- Small ribosomal subunit protein uS12cz/uS12cy
- Small ribosomal subunit protein uS12m
- Ribonuclease III domain-containing protein RNC1, chloroplastic
- Ribosomal protein S12
- CRM-domain containing factor CFM2, chloroplastic
- Cytosolic sulfotransferase 5
- Photosystem I assembly protein Ycf3
Sequence:
MDNGGSVLSLSAPHFPYSATILRRHSPVASISFSLKQPPPQPPEPPESPPDLRRPEKSIGSSSSSSSPSPIPSPKTPLKINPLKGLTNRSSVSPLVQSEVSSKVSSFGSSLASKLRLSSKLSPPPPPPPPPPVEETTQFRDEFRSDTKPPEEETRNPQQEFRQEGKIFVGNLPTWIKKPEFEEFFRQFGPIENVILIKGHHEVEKNAGFGFIIYAAEKSAMKAVEFDGVEFHGRILTVKLDDGKRLKTKAEQRVRWVEEGEEDTKMSNKSSWHQEREGSRKSLQRILDTNGDNWQAVISAFEKISKPSRTEFGLMVKFYGRRGDMHRARETFERMRARGITPTSRIYTSLIHAYAVGRDMDEALSCVRKMKEEGIEMSLVTYSVIVGGFSKAGHAEAADYWFDEAKRIHKTLNASIYGKIIYAHCQTCNMERAEALVREMEEEGIDAPIAIYHTMMDGYTMVADEKKGLVVFKRLKECGFTPTVVTYGCLINLYTKVGKISKALEVSRVMKEEGVKHNLKTYSMMINGFVKLKDWANAFAVFEDMVKEGMKPDVILYNNIISAFCGMGNMDRAIQTVKEMQKLRHRPTTRTFMPIIHGYAKSGDMRRSLEVFDMMRRCGCVPTVHTFNGLINGLVEKRQMEKAVEILDEMTLAGVSANEHTYTKIMQGYASVGDTGKAFEYFTRLQNEGLDVDIFTYEALLKACCKSGRMQSALAVTKEMSARNIPRNSFVYNILIDGWARRGDVWEAADLIQQMKKEGVKPDIHTYTSFISACSKAGDMNRATQTIEEMEALGVKPNIKTYTTLIKGWARASLPEKALSCYEEMKAMGIKPDKAVYHCLLTSLLSRASIAEAYIYSGVMTICKEMVEAGLIVDMGTAVHWSKCLCKIEASGGELTETLQKTFPPDWSSHHHHHGFLDQVSDVDSDEDDVDGEDGEDDEDVNSVSDLLSPYK
Protein: Large ribosomal subunit protein mL38 (39S ribosomal protein L38, mitochondrial) (L38mt) (MRP-L38) (Q8K2M0)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q96DV4}.
Interaction partners:
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein mL37
- Large ribosomal subunit protein mL52
- 39S ribosomal protein L40
- Large ribosomal subunit protein uL4m
- Small ribosomal subunit protein uS10m
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein mL62
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein mS27
Sequence:
MAAPWWRAAFFGIGRCRGFSTSAFLSRRTPPLGPMPNEDIDVSNLERLEKYRSFERYRRRAEQEARAPHWWRTYREHFVKETDPKDKIDIGLPPPRVSRTQKLLERKHFLRELRANVEEERAARLRTASIPLEAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPWVPLHVAYAVGEEDLIPVYHGNEVTPTEASRAPEVTYEADKDSLWTLLFINLDGHLLEPDAEYVHWLLTNIPSNRVAEGQETCPYLPPFPARGSGFHRFAFLLFKQDKPINFSEDTRPSPCYQLAQRTFRTFDFYKRHQEAMTPAGLAFFQCRWDDSVTHTFHQLLDMREPVFEFVRPPPYHPKQKRFPHEQPLRYLDRYRDSHEPTYGIY
Protein: Wax ester synthase/diacylglycerol acyltransferase 6 (WS/DGAT 6) (Diacylglycerol O-acyltransferase WSD6) (EC 2.3.1.20) (Long-chain-alcohol O-fatty-acyltransferase WSD6) (EC 2.3.1.75) (Q9M3B1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional wax ester synthase/diacylglycerol acyltransferase that uses acyl-CoAs with 16, 18 and 20 carbons as substrates, preferably in combination with 16:0ol alcohol. Involved in cuticular wax biosynthesis (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5KS41}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30729606}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:30729606}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Diacylglycerol kinase 6
- Protein DETOXIFICATION 51
- Cytochrome P450, family 96, subfamily A, polypeptide 1
Sequence:
MEIKTRRDTSETSVRKDDEEEVEEEQPLSPAARVFHAPEFNCYVISVIGIKKKIDPDVIIEGLKQTLIRHPRFSSKMVSTSVGNKKRQTQSWVRTNVVVTDHVIVSDIQTQNIENGNADAFLETYVSNLTTVPLDISKPLWQLHLLDLKTSDAENVAVLKFHHSLGDGMSLMALVLACMRKTSNPDELPSLPNQNRSSSRSSRLMAGSRGDSRFLWLVMVIWSAIMLVLNTVCDALEFIATTMFLKDTETPIKGDFRFSKSKRMCLVHRTVSLDDIKLIKNTMKMTVNDVVLGVSQAGLSQYLDRRYGEKKKKVGEDQDSKRKATDMPKRIRLRSALLVNLRPNTGIQDLADMMAKGSTCRWGNWIGYIVFPFSIGLRDDPLQHLRRAKRIIDRKKNSLEAALTFVAGKFILKTFGVQVAAKIINRALSNTTMSFSNLIGPIEEISFYGHPITYMAPSVYGHPHALTMHFQSYMNQMTISLTVDPTVISDPHRLLDDWEKSLQSIKAAVQERDSRSLD
Protein: Aromatic dipeptide epimerase (EC 5.1.1.-) (A9B055)
Organism: Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785 / 114-95)
Function: Has epimerase activity with a variety of hydrophobic dipeptides (in vitro). Enzyme activity is highest with L-Phe-L-Tyr, but is still relatively low, suggesting that L-Phe-L-Tyr is not the physiological substrate.
Interaction partners:
Sequence:
MPTTIQAISAEAINLPLTEPFAIASGAQAVAANVLVKVQLADGTLGLGEAAPFPAVSGETQTGTSAAIERLQSHLLGADVRGWRKLAAMLDHAEHEAAAARCGLEMAMLDALTRHYHMPLHVFFGGVSKQLETDMTITAGDEVHAAASAKAILARGIKSIKVKTAGVDVAYDLARLRAIHQAAPTAPLIVDGNCGYDVERALAFCAACKAESIPMVLFEQPLPREDWAGMAQVTAQSGFAVAADESARSAHDVLRIAREGTASVINIKLMKAGVAEGLKMIAIAQAAGLGLMIGGMVESILAMSFSANLAAGNGGFDFIDLDTPLFIAEHPFIGGFAQTGGTLQLADVAGHGVNLA
Protein: Melanopsin (Opsin-4) (amphi-MOP) (Q4R1I4)
Organism: Branchiostoma belcheri (Amphioxus)
Function: Photoreceptor implicated in non-image-forming responses to light. Photoisomerizes covalently bound all-trans retinal back to 11-cis retinal. Most likely coupled to the G(q) signaling cascade.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9QXZ9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MTEIPSFQPPINATEVEEENAVFPTALTEWFSEVGNQVGEVALKLLSGEGDGMEVTPTPGCTGNGSVCNGTDSGGVVWDIPPLAHYIVGTAVFCIGCCGMFGNAVVVYSFIKSKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDFACELYGFAGGLFGCLSINTLMAISMDRYLVITKPFLVMRIVTKQRVMFAILLLWIWSLVWALPPLFGWSAYVSEGFGTSCTFDYMTPKLSYHIFTYIIFFTMYFIPGGVMIYCYYNIFATVKSGDKQFGKAVKEMAHEDVKNKAQQERQRKNEIKTAKIAFIVISLFMSAWTPYAVVSALGTLGYQDLVTPYLQSIPAMFAKSSAVYSPIVYAITYPKFREAVKKHIPCLSGCLPASEEETKTKTRGQSSASASMSMTQTTAPVHDPQASVDSGSSVSVDDSSGVSRQDTMMVKVEVDKRMEKAGGGAADAAPQEGASVSTVSAQIEVRPSGKVTTKADVISTPQTAHGLSASPVPKVAELGSSATLESAAIPGKIPTPLPSQPIAAPIERHMAAMADEPPPKPRGVATTVNVRRTESGYDRSQDSQRKKVVGDTHRSRSFNTTKDHFASEQPAALIQPKELYSDDTTKKMARQSSEKHEYDNPAFDEGITEVDTDSENETEGSYDMLSVRFQAMAEEPPVETYRKASDLAINLGKASLMLSEAHDETVL
Protein: Probable xyloglucan endotransglucosylase/hydrolase protein 28 (At-XTH28) (XTH-28) (EC 2.4.1.207) (Q38909)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity).
Subcellular location: Secreted, cell wall {ECO:0000305}. Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
Sequence:
MGFITRFLVFMSLFTSLVSGFALQKLPLIQFDEGYTQLFGDQNLIVHRDGKSVRLTLDERTGSGFVSNDIYLHGFFSSSIKLPADYSAGVVIAFYLSNGDLYEKNHDEIDFEFLGNIRGREWRIQTNIYGNGSTHLGREERYNLWFDPTEDFHQYSILWSLSHIIFYVDNVPIREVKRTASMGGDFPAKPMSLYSTIWDGSKWATDGGKYGVNYKYAPYVSQFTDLILHGCAVDPTEKFPSCKDEAVQNLRLASEITESQRNKMEIFRQKHMTYSYCYDHMRYKVVLSECVVNPAEAKRLRVYDPVTFGGIPHGHRRGKHRSRSRLARTESI
Protein: Hypothetical membrane protein (Q8NTB5)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- Hypothetical membrane protein
- ABC-type transporter, periplasmic component
- ABC-type transporter, ATPase component
- Peptidase S1 domain-containing protein
- ABC-type transporter, permease components
- ABC-type Fe3+-siderophores transport systems, periplasmic components
- ABC-type transporter, permease components
- ABC-type transporter, ATPase component
- HTH-type transcriptional regulator RipA
- DUF732 domain-containing protein
Sequence:
MNKLATRALVALTGSAIAMTGLTVVSANAAEKTGKCRVVTTTGTADWSVRESFNNYLEGPIANGAAYKYHGGIEVRDGVETTGTKSAREFTWPVLGSEEGAVKLGGGVHWTGHNHYSGDDESQAPDNFILDLDFSNPTVKFDGNEGTLLVDFKSREFVDTKTVADFLTGTQAELATITFDEPIDLTQENVTVTGQTKLTATGVDVMGTFYPEGEALAPITLNLTNEVVCDEPETPVEPEVPVEPETPVDPETSVDPETPVDPETSVDPEKPGDDNKDDGSNSSSNGDILGILGILAALGGVGALVYNFLVASGFLAAFK
Protein: Glutaminyl-peptide cyclotransferase-like protein (EC 2.3.2.5) (Golgi-resident glutaminyl-peptide cyclotransferase) (isoQC) (gQC) (Q9NXS2)
Organism: Homo sapiens (Human)
Function: Responsible for the biosynthesis of pyroglutamyl peptides.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18486145}; Single-pass type I membrane protein {ECO:0000269|PubMed:18486145}.
Interaction partners:
- Gastric inhibitory polypeptide receptor
Sequence:
MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTEELPLGRELRVPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYLGL
Protein: Methylmalonyl-CoA mutase small subunit (EC 5.4.99.2) (MCB-beta) (P11652)
Organism: Propionibacterium freudenreichii subsp. shermanii
Function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.
Interaction partners:
Sequence:
MSSTDQGTNPADTDDLTPTTLSLAGDFPKATEEQWEREVEKVLNRGRPPEKQLTFAECLKRLTVHTVDGIDIVPMYRPKDAPKKLGYPGVAPFTRGTTVRNGDMDAWDVRALHEDPDEKFTRKAILEGLERGVTSLLLRVDPDAIAPEHLDEVLSDVLLEMTKVEVFSRYDQGAAAEALVSVYERSDKPAKDLALNLGLDPIAFAALQGTEPDLTVLGDWVRRLAKFSPDSRAVTIDANIYHNAGAGDVAELAWALATGAEYVRALVEQGFTATEAFDTINFRVTATHDQFLTIARLRALREAWARIGEVFGVDEDKRGARQNAITSWRDVTREDPYVNILRGSIATFSASVGGAESITTLPFTQALGLPEDDFPLRIARNTGIVLAEEVNIGRVNDPAGGSYYVESLTRSLADAAWKEFQEVEKLGGMSKAVMTEHVTKVLDACNAERAKRLANRKQPITAVSEFPMIGARSIETKPFPAAPARKGLAWHRDSEVFEQLMDRSTSVSERPKVFLACLGTRRDFGGREGFSSPVWHIAGIDTPQVEGGTTAEIVEAFKKSGAQVADLCSSAKVYAQQGLEVAKALKAAGAKALYLSGAFKEFGDDAAEAEKLIDGRLFMGMDVVDTLSSTLDILGVAK
Protein: Enoyl-CoA hydratase/isomerase domain-containing protein (Q383R4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Mitochondrial ribosomal protein S18
- Small ribosomal subunit protein uS5 C-terminal domain-containing protein
- Treble clef zinc finger domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- 30S Ribosomal protein S17, putative
- Uncharacterized protein
- Uncharacterized protein
- Trans-sialidase
Sequence:
MERRRLLHDGRWFTPPVLYGSARRGLKTLDVREYRPLAMPIEFRFYQRYANHPNRQSGIQFLTHYNTHQRFRVNKDYIDYMHWGKEQGQARLPHRHQRVAFDFNDQLHPTRIGTPEDGGNANHCYPEDGEDGSYAWFASQDPTFGHHPDLSSSFDPNYRVFSHPEHWNKMFTKRRPGEGDIDLSVLPSRSLLGPLMAHSDTKGIPYFKVDNRGHSNGRVPGVNAPFFGEFDQKMMQAMSRPLNANRTITGNDGRFSKTIMINEPQCNQALSAKTASELSKEIDKATNAVYSKLSVLEAAQSGLTDYFCGGLNFEIVGFELHMAAMLRERAAAILERSGAGGLPSASSATLSSSSTTRRCAMLLEKADEREVNKLLRDASRYEDRVDDALRQHASLIWRVYTAPRPLMTLTNGKCRGTGCGLSLFAKYCALKDSSEFIFDGPNVGITPYGGMTRLLARPETSLKYPGLAEFVVLTGASLFAGDALRLGWTDLFTTIPDMTYHIKEWFDTTEHMHNDAVAWQLGHLLETCFKMKESHSSAMERAAITPTRARWVEDAFADQPSVNDIMRTLTEIEQLPFQSTHNTSDESHITPYTLGSVAAGVQRLGEHRLRYTLSPWDITPPEDSVVLKHTSEMFRAYVLERRGATDVVTHRDAERAAAWSQQRQREYDAYCSLKEAPHPRHVYARLEGCEGKIVSFEFVFEISCRRSGPQGTDEVLQATTISRLKSRILDALGMPRDRNIDLGWYLPTLDTCPIHSDEELMQVLHTDPGIEDPKEKLRYPPIYFIVKRCTLYFSEWAYAVKHQLLLQSPFALRAAFGLLQEVRGDGAAENVMPLAETLGTEFKYFTRLMRRPDFYRVGVHTDKSVEKWEEIKEERRHNIHHTHRPTRPLPDFEEVFERDVEIDGHRFVLRPRWNPRTLQDVDDSDILRLRAPLTYDMDSTAALHVPTHCGKASRLAGMLQDAGGVQVLDGLGEVDDKGEPKVPPLQSNASVPTNVSFYEMARHPWEDRASSWRRDGFTEGSLEYFESQYRSAERAVYDEEGRGVRNYWPSRDAVEGIAQEEENDAQLLQERLFNTLETAGTSVEPWARNLRLNATTGKFGYKTEIATQEEKIYDDEYYRWFIQPGRHPNPSGLTLNGRKGQFEEGHSRDEELERMWRKVVADGNNDFAATTSGMPVYDGDAKNAEDSYAAGDDVDVVTTDANVPVDGDDSS
Protein: Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase) (P33261)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position. Catalyzes the epoxidation of double bonds of PUFA. Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol. Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 2C9
- Cytochrome P450 3A4)
- Cytochrome P450 3A5
- Peptidyl-prolyl cis-trans isomerase G
- Cytochrome P450 4A11
- Cytochrome P450 4F2
- Polyunsaturated fatty acid 5-lipoxygenase
- Epoxide hydrolase 1
- Cytochrome P450 1A2
- Cytochrome P450 4F3
Sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
Protein: Protein NSP-INTERACTING KINASE 1 (AtNIK1) (EC 2.7.11.1) (LRR receptor-like serine/threonine-protein kinase NIK1) (Q9LFS4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in defense response to geminivirus and begomovirus infection via regulation of the nuclear trafficking of RPL10A. Phosphorylates RPL10A in vitro. Activation of NIK1 down-regulates cytosolic translation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15489295}; Single-pass type I membrane protein {ECO:0000269|PubMed:15489295}.
Interaction partners:
- Large ribosomal subunit protein uL16z
- L10-interacting MYB domain-containing protein
- Large ribosomal subunit protein uL10c
- Transmembrane receptor
- Presenilin-like protein At2g29900
- Membrane-associated kinase regulator 5
- Large ribosomal subunit protein uL16y
- Receptor protein kinase-like protein At4g34220
Sequence:
MESTIVMMMMITRSFFCFLGFLCLLCSSVHGLLSPKGVNFEVQALMDIKASLHDPHGVLDNWDRDAVDPCSWTMVTCSSENFVIGLGTPSQNLSGTLSPSITNLTNLRIVLLQNNNIKGKIPAEIGRLTRLETLDLSDNFFHGEIPFSVGYLQSLQYLRLNNNSLSGVFPLSLSNMTQLAFLDLSYNNLSGPVPRFAAKTFSIVGNPLICPTGTEPDCNGTTLIPMSMNLNQTGVPLYAGGSRNHKMAIAVGSSVGTVSLIFIAVGLFLWWRQRHNQNTFFDVKDGNHHEEVSLGNLRRFGFRELQIATNNFSSKNLLGKGGYGNVYKGILGDSTVVAVKRLKDGGALGGEIQFQTEVEMISLAVHRNLLRLYGFCITQTEKLLVYPYMSNGSVASRMKAKPVLDWSIRKRIAIGAARGLVYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHQDSHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELVTGQRAFEFGKAANQKGVMLDWVKKIHQEKKLELLVDKELLKKKSYDEIELDEMVRVALLCTQYLPGHRPKMSEVVRMLEGDGLAEKWEASQRSDSVSKCSNRINELMSSSDRYSDLTDDSSLLVQAMELSGPR
Protein: Photosystem II CP43 reaction center protein (PSII 43 kDa protein) (Protein CP-43) (P09193)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation (By similarity). Required for correct assembly of PSII.
Subcellular location: Cellular thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01496, ECO:0000269|PubMed:12069591, ECO:0000269|PubMed:34937700, ECO:0000269|PubMed:9512353}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01496, ECO:0000269|PubMed:34937700, ECO:0000269|PubMed:9512353}. Note=PsbQ binds to the large lumenal domain of this protein between PsbO and PsbV. {ECO:0000269|PubMed:34937700}.
Interaction partners:
- Photosystem II protein D1 2
- Photosystem II extrinsic protein U
- Photosystem II reaction center protein K
- Photosystem II reaction center protein Z
- Photosystem II CP47 reaction center protein
- Photosystem II extrinsic protein O
- Cytochrome b559 subunit alpha
- Photosystem II reaction center protein H
- Photosystem II reaction center protein L
- Photosystem II reaction center protein I
Sequence:
MVTLSNTSMVGGRDLPSTGFAWWSGNARLINLSGKLLGAHVAHAGLIVFWAGAMTLFEVAHFIPEKPMYEQGLILLPHIATLGWGVGPAGEVTDIFPFFVVGVLHLISSAVLGLGGIYHALRGPEVLEEYSSFFGYDWKDKNQMTNIIGYHLILLGCGALLLVFKAMFFGGVYDTWAPGGGDVRVITNPTLNPAIIFGYLLKAPFGGEGWIISVNNMEDIIGGHIWIGLICISGGIWHILTKPFGWARRALIWSGEAYLSYSLGALSLMGFIASVFVWFNNTAYPSEFYGPTGMEASQSQAFTFLVRDQRLGANIASAQGPTGLGKYLMRSPSGEIIFGGETMRFWDFRGPWLEPLRGPNGLDLDKLRNDIQPWQVRRAAEYMTHAPLGSLNSVGGVITDVNSFNYVSPRAWLATSHFVLGFFFLVGHLWHAGRARAAAAGFEKGIDRETEPTLFMPDLD
Protein: Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3) (O35492)
Organism: Mus musculus (Mouse)
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Subcellular location: Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome.
Interaction partners:
Sequence:
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERAPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR