wanglab/gogpt-training-data huggingface dataset:
Protein: Protein OXIDATIVE STRESS 3 LIKE 1 (AtO3L1) (Q9C593)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes slightly the tolerance to zinc (Zn) and to oxidizing chemicals (e.g. diamide).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9LVB9}.
Interaction partners:
- Heavy metal-associated isoprenylated plant protein 39
- Homeobox-DDT domain protein RLT2
- Cation/calcium exchanger 1
- Ethylene-responsive transcription factor 8
- Homeobox-DDT domain protein RLT1
- Non-specific lipid-transfer protein 4
Sequence:
MDCVESYLSGDNSDESPVMHTWFSPSPSPSDSSSSPSSSASSSIGRNSDDGEKSSEDGGDDAGENEVESPYKGPLEMMESLEQVLPVRKGISKYYSGKSKSFTNLTAEAASALTSSSSMKDLAKPENPYSRRRRNLLCHQIWENNKTTPRGGISKKHVMSSSRSALTLAMAVAAGVMTGEGSSSGGDSSPGSSPTTSGSPPRQLHHHQHQMKKLPPLYPRSQGSFGNLTSSQSSLGFCAWRSFSVADFPRCFPATASGIGFNDS
Protein: Kinetoplast polyadenylation/uridylation factor 1 (Q587F7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 30S Ribosomal protein S17, putative
- Large ribosomal subunit protein uL3m
- Kinetoplast polyadenylation/uridylation factor 2
Sequence:
MFQRRLVLCSRLVFAASDCCLNRATSFQPFSQRDEEDLIRVVKTKPRHVLKHVRQQVWRSRKRELHFRNTVTHLMIVLQEFLRKQMIDPANASQIMEGIMEECVKYSQHDMAHLLFRAFLRFRKYGCVITVDALRHLFESYKENDSSDLMLQLANEMRGDPALRALCVAAYLFANHLEEAETLQEGLAFSDLTRDDIIALIEGYDKLNKTEKIMDVLKNVTEITKNDGGAKSVRLEPDDLDAIFRSFFRVFHRRDDDTAFTEVFQAAFRGSVKLDSQTFAIILRQRMRHVTCMEEITAVEQELQEFGYTPDVTGNSILISAYARLVHFGDRGSEELMLAKVDTLLSSIESRLRQGDPDMDVSAAHIRAVIRGYGAAGRPESIKSAWARMQCKGLSDDIRVYNELFKWFALMGSVKDVMGLKEEMDAAGLHADSQTYTWILRALGKYYPRHVEKLYDEMTTRHVRPDTQLYTTLIGIFGDVGDMARVEAITQEMMRREEAGTLQLTPVTFAVLIRVHAADLAKAEEIYRESKKRAMNDHPHVQTSMLHVYANHGEGSEGLDSFLKEIPTWTTDVYNVLLNKYGKACDREKVEELVRQMKEKDVAMNDVTFGTLITAYARWGNGEKVREMIQLLKEHEGEVSATFYSVLASSLSRMGDMEGVSNAWDDLIASKLFPDTEVYNQFLLLYSRQHNAGKMQAVLNNMMKHVPPNPVTATTILDMLGKSGRVAEMESLFEDMKSSADTMPTAVTYHQMMNTYAKTGDIVKMEKLHAEYVEKGHNNNAVTYNILADGYGRARRLEQMEEVFQQRRKAEVPMDDLGYCIMVAAYGRLRVKKEVLRLYADVSSTANSHLFTRKVTWAFIDAFCRCSAPEEMEKCVEVLKKSNEGNVLSGGDILALIPYYCRLGDMNRVEKLRLQAEELKAEMSYSALNAMARGYAKNGQFEKTVETLHLLRDRNWVPDASTALFLSGAFLKAGLHEQAQQIVQWRRQYAKHAGEEMAAGADV
Protein: Thrombospondin, isoform G (Thrombospondin, isoform H) (B7Z030)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGHEVNGTSCRDMNECLLYDPCDELATCTNLSPGFQCSPCPVGFDGTHAHGYFADYYSVDYRRQTCLDVDECRTGFFRCPEHSTCINEIGSYRCQCHEGYVTNGTYSCLDRSSVFMCPDGTVCDRNAVCLRMDNIRHKCHCNVGWAGNGLICGRDTDVDGWPDQAIGCPELRCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNSQDNCWLAYNTEQLDSDGDKVGDVCDNCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQSDVDNDGVGDACDNCPNLPNPDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPMVSNSDQLDTDGDGTGDECDDDMDGDGIPNYKDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDGVPNGMDNCPNNSMIHHTDFRTLQTIPLDPKGLSQADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGTFYINDDTDDDYAGFVFSYQSSYKYYVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGNTDGEARLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSGNVFDSTLKGGRLGVFCFSQRMIIWSNLQYKCNNRVKPLIYNDLSDYLKTKVELQD
Protein: Delta(5) fatty acid desaturase fat-4 (FAT-4) (EC 1.14.19.37) (EC 1.14.19.44) (FAT-4 Delta(5) desaturase) (Fatty acid desaturase 4) (G5EG11)
Organism: Caenorhabditis elegans
Function: Can function as a Delta(5) fatty acid desaturase and behaves as a (8-3) desaturase. Introduces a double bond in the fatty acid chain 5 carbons away from carboxy terminal to biosynthesize polyunsaturated fatty acids (PUFAs) endogenously (PUFAs are essential for membrane structure and many cellular and physiological processes). Acts on a variety of substrates such as dihomo-gamma-linoleoyl-CoA ((8Z,11Z,14Z)-eicosatrienoyl-CoA, 20:3n-6) to generate arachidonoyl-CoA ((5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA, 20:4n-6). Also acts on a number of other substrates, including fatty acids that do not contain a double bond at the 8 position like (11Z,14Z,17Z)-eicosatrienoyl-CoA (20:3n-3) to produce (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA (20:4n-3). Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Omega-3 fatty acid desaturase fat-1
- Delta
- Delta
- 2Fe-2S ferredoxin-type domain-containing protein
- Long chain fatty acid elongase 1
- Long chain fatty acid elongase 2
- Delta
- Delta
- Fatty acid synthase
- Alkylglycerol monooxygenase
Sequence:
MVLREQEHEPFFIKIDGKWCQIDDAVLRSHPGGSAITTYKNMDATTVFHTFHTGSKEAYQWLTELKKECPTQEPEIPDIKDDPIKGIDDVNMGTFNISEKRSAQINKSFTDLRMRVRAEGLMDGSPLFYIRKILETIFTILFAFYLQYHTYYLPSAILMGVAWQQLGWLIHEFAHHQLFKNRYYNDLASYFVGNFLQGFSSGGWKEQHNVHHAATNVVGRDGDLDLVPFYATVAEHLNNYSQDSWVMTLFRWQHVHWTFMLPFLRLSWLLQSIIFVSQMPTHYYDYYRNTAIYEQVGLSLHWAWSLGQLYFLPDWSTRIMFFLVSHLVGGFLLSHVVTFNHYSVEKFALSSNIMSNYACLQIMTTRNMRPGRFIDWLWGGLNYQIEHHLFPTMPRHNLNTVMPLVKEFAAANGLPYMVDDYFTGFWLEIEQFRNIANVAAKLTKKIA
Protein: Exosome component 5 (M0R102)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPAGVSGWQSGLAFFPLESSIIPAGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALDSDGTLVLDPTSKQEKEARAVLTFALDSVERKLLMSSTKGLYSDTELQQCLAAAQAASQHVFRFYRESLQRRYSKS
Protein: dTMP kinase (EC 2.7.4.9) (A0A8I6AFQ3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
NFHVTRARKTLVGRIGPFRELQTEVPGVGVRSSAGWGPRLRHVRKRFPAVFSAPLPAGRERSTEIGKLLSSYLEKKTELEDHSVHLLFSANRWEQVPLIKAKLNQGVTLVLDRYAFSGVAFTSAKENFSLDWCKQPDVGLPKPDLILFLQLQLLDAASRGEFGLERYETGTFQEQVLLCFQQLMSEKNLNWKVVDASKSIEDVHEEIRALSEDAIQNAAQRPLEELWK
Protein: Protein EPIDERMAL PATTERNING FACTOR 2 [Cleaved into: MEPF2] (Q8LC53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Controls stomatal patterning. Regulates the number of cells that enter, and remain in, the stomatal lineage by inhibiting protodermal cells from adopting the meristemoid mother cell (MMC) fate in a non-cell-autonomous manner. Mediates stomatal development inhibition. MEPF2: mobile signal controlling stomatal development in a non-cell-autonomous manner. Uses ERECTA as major receptor. Inactivated by cleavage by CRSP (AC Q9LNU1). May act by competing with somatogen (AC Q9SV72) for the same receptor, TMM (AC Q9SSD1).
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- LRR receptor-like serine/threonine-protein kinase ERL1
- LRR receptor-like serine/threonine-protein kinase ERL2
- Protein TOO MANY MOUTHS
- EPIDERMAL PATTERNING FACTOR-like protein 9
- Transcription factor SPEECHLESS
- LRR receptor-like serine/threonine-protein kinase ERECTA
- Transcription factor MUTE
- EPIDERMAL PATTERNING FACTOR-like protein 4
- EPIDERMAL PATTERNING FACTOR-like protein 6
- Protein BREAKING OF ASYMMETRY IN THE STOMATAL LINEAGE
Sequence:
MTKFVRKYMFCLVLVFAACSLVVNSIRTPPLKNTVNGGEKKNADIEQAQTHHKKEISKNGGVEMEMYPTGSSLPDCSYACGACSPCKRVMISFECSVAESCSVIYRCTCRGRYYHVPSRA
Protein: Small ribosomal subunit protein uS10 (40S ribosomal protein S20) (A1XQU9)
Organism: Sus scrofa (Pig)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P60866}.
Interaction partners:
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS13
- Small ribosomal subunit protein uS7
- 40S ribosomal protein S30
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS21
Sequence:
MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIPKRLIDLHSPSEIVKQITSISIEPGVEVEVTIADA
Protein: Transcriptional adapter 2B (dADA2b) (Q8I8V0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:12482983, ECO:0000269|PubMed:12697829}.
Interaction partners:
- SAGA complex subunit Spt3
- Transcription initiation factor TFIID subunit 12
- SAGA-associated factor 11 homolog
- Enhancer of yellow 2 transcription factor
- SAGA complex subunit Spt7
- Transcription initiation factor TFIID subunit 9
- SAGA factor-like TAF6
- Transcriptional adapter 1-2
- SAGA-associated factor 29kDa
- Transcription initiation factor TFIID subunit 10b
Sequence:
MTTIADLFTKYNCTNCQDDIQGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTSILSVFRGKGAWTAREEIRLLDAIEQYGFGNWEDISKHIETKSAEDAKEEYVNKFVNGTIGRATWTPAQSQRPRLIDHTGDDDAGPLGTNALSTLPPLEINSDEAMQLGYMPNRDSFEREYDPTAEQLISNISLSSEDTEVDVMLKLAHVDIYTRRLRERARRKRMVRDYQLVSNFFRNRNYAQQQGLTKEQREFRDRFRVYAQFYTCNEYERLLGSLEREKELRIRQSELYRYRYNGLTKIAECTHFEQHAATATHRSTGPYGHGKTDHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAPRNTLHIADPTCSGALLPSKNYLDSCRGSSAATMLQTTGMVMGVTVDSGATTGVTSTATTMANLPTNSAKGSQQHLQPLQQHPQLLQSGNQHKMQNEAAGGGSDQVPSMSLKLRTQLEELKHLPQPPGSELLSHNELDLCKKHNITPTTYLSVKTVCLSGAPSLGSPMETSLRKFFIKCGWLSH
Protein: Opsin-1, short-wave-sensitive 2 (Blue cone photoreceptor pigment) (Blue-sensitive opsin) (Opsin SWS-2) (Q9W6A8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Cone transducin alpha subunit, alpha transducing activity polypeptide 2) subunit alpha-2)
- Clusterin
- Arrestin-C
- Gnb3 protein, beta polypeptide 3), beta polypeptide 3b)/G
- ZPR1 zinc finger.
Sequence:
MKQQQQTPELFEDFHMPITLDVSNISAYSPFLVPQDHLGHSGVFMGMSAFMLFLFIAGTAINVLTIVCTIQYKKLRSHLNYILVNLAISNLWVSVFGSSVAFYAFYKKYFVFGPIGCKIEGFTSTIGGMVSLWSLAVVALERWLVICKPLGNFTFKTPHAIAGCILPWCMALAAGLPPLLGWSRYIPEGLQCSCGPDWYTTNNKFNNESYVMFLFCFCFAVPFSTIVFCYGQLLITLKLAAKAQADSASTQKAEREVTKMVVVMVFGFLICWGPYAIFAIWVVSNRGAPFDLRLATIPSCLCKASTVYNPVIYVLMNKQFRSCMMKMVFNKNIEEDEASSSSQVTQVSSVAPEK
Protein: sn-1-specific diacylglycerol lipase (EC 3.1.1.116) (B7Z151)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MPGLVVFRRRWSVGSDDLVVPGAFLLTIHFICFVIVSVSLVIFEYNTRILSVKLLFYHLIGYLLILFFSICVEIGICVISMRGSILDAEARTSINIWIYLKSLVILFDIAWLAVGSVWLGHYYTTAPIDDPKKVYIAIIICNWALVVITLITIWCTFDAAGRSWVKMKKYQRSMRETESRFNYKRSNSMNRNWRQRKVMRAYQDSWDHRCRLLFCCMGSSERNRNSFTDIARLLSDFFRELDVVPSDVVAGLVLLRKFQRLEREAIVRQRKNGTYEFLSGVPITERTQFLALNDAKNYDFFQTVIHYMYFAQGAYGWPMYVIINRSKMWHLVPELKCFGCCCGTSDDTEVIQDNCCLCNYAALKKTLQLGDIDIVYATYHVDVGETPFFVAIDYTHRAVVISIRGTLSMKDILTDLNAEGEVLPLQPPRDDWLGHKGMVQAAIYIRNKLQEENLIERALQRNPDRQTHTFDLVLVGHSLGAGTAAILAILLKPEHPTLQCFSYSPPGGLLSMPAVEYSKSFITSVVLGKDVVPRIGLNQMEALRADLINAIQRSVDPKWKTISCSVICCGCGPEPTSVVNMSGQDTHINQYQEERGTARSTSAHPTDSSIALTLHQPLYPPGRIIHIVRHHPKPDEQKYDSGWRNVLKNREPVYQAIWADSTDFDEVLISPVMLQDHMPDKVLAALKKVVSCRDRTVKACTTRRRNDNTTITTTTTVTTTTTTTQNTDTSSHPPSNHTSPQRTIEPLAILPTSYSLNFDVTVLSHSTSLANCICYCLFPLSLICETVHTCIPLSLATSTRLFLHLYVTTSCEDQD
Protein: Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE) (Q9USZ3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- U1 small nuclear ribonucleoprotein C
- Pre-mRNA-splicing factor cwf4
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor cwf14
- Small nuclear ribonucleoprotein F
- Pre-mRNA-splicing factor spp42
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein-associated protein B
Sequence:
MSGRVQKVMIPPINFIFKLLQQHTPVSIWLFEQTDIRLQGQIRGFDEFMNIVLDDAVQVDAKNNKRELGRILLKGDNITLIQAI
Protein: Jonah 65Aiv (EC 3.4.21.-) (LP10918p) (Q9VRS6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Trypsin beta
- trypsin
- GH01508p
- Trypsin alpha
- Uncharacterized protein
- Trypsin epsilon
- Zinc carboxypeptidase A 1
- Jonah 25Bii, isoform A
- Jonah 25Biii
- Jonah 99Fii
Sequence:
MKFLIILALAVAASAFPEPELRHRSREMPVVGDIGGRITGGSNAAVGQFPYQVGLSLKLSALSSAWCGGSLIGSTWVLTAAHCTDGVQSVTVYLGATVRTSAEITHTVSSSDIIIHSGWNSANLRNDISLIKIPATSSSSRISAVKLPSISNSYSTFVGDVAVASGWGRTSDTSSGVATNLQYVDLTVITNTKCAQTYGTSVVTDSTLCVATTDAKSTCNGDSGGPLVLKSSSEQIGLTSFGASAGCEKGYPAAFTRVTSYLDWIKTNTGI
Protein: EF-hand domain containing 1.1 (Q9VXP5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000256|ARBA:ARBA00004430}.
Interaction partners:
- GH16267p
- Parkin coregulated gene protein homolog
- Cilia- and flagella-associated protein 52
Sequence:
MLRIPGMPLLPGTLFRDVSKGHYPKPQSLANVQGLSMLSDRQQPAPVESGSVTVDISCPPVGASSIYPPRSGPRMPPWLAYDKKVLCFHAYFKQTLQEVYHAPYLVRKVKIYYYLEDGTLEIYEPRVDNSGIVQGCVVHRQRVQKAPPCDNEFMSLIDLNVDQTVQIFDRQYHITDCDPFTRTFLNKRGITVPDPVKSPCDPTEEQRKRENQPRSGNLIPKNHPFAQFLKYDRQILKFQAYWDDRTEFGDVRKLELCYYLSDDTIEIKEQHIRNSGRDGPTVFLKRGRLAREFEGLQLPGQMTPMTLLNVLGTNMRNVRYCVDPLNTGNKEIHYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRYGIQDFTPLPIPARSDDCADHRSERQLPPYNGWGSYEDSVGNCISVEPKPPKSDFKKFIKYDRYVLRFGAKMLSTIKANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQERFSCKQPQYYMPWNFFVGSTMSLKDFIFHIVSADEYTLMYMEHHPEIFPHANVGVIMEKVKSALQNRMAEFVGSCVPDCTDLEKKRDVFVSFESFKGALISIMGNQISDHEIISLCRHFSAEKSQPNACDRSTVRAAAHLELKRTLWNARDDLMEHFHHINPTNQPFLPEVKVRSALRGCRLPFSLELIDNILSILNRNECDDIEVCDLMNFIDVSCGKGCDMLPVNHAFELCPKIPFLNKGRVVNFTCFLRELNLPLNLPAGGEKNNDAIAEGGRIMPPSAMPDTDAHKANEDDAQHMA
Protein: DELLA protein RGL1 (GRAS family protein 9) (AtGRAS-9) (RGA-like protein 1) (RGA-like protein) (Q9C8Y3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. No effect of the BOI proteins on its stability. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes. Has overlapping but distinct roles in GA signaling compared to RGA and GAI. Regulates the floral development. May also participate in seed germination and in ovule and anther development. Its activity is probably regulated by other phytohormones such as auxin and ethylene.
Subcellular location: Nucleus {ECO:0000269|PubMed:11826301}.
Interaction partners:
- Gibberellin receptor GID1A
- Gibberellin receptor GID1B
- Gibberellin receptor GID1C
- F-box protein GID2
- Transcription factor PIF3
- Transcription factor PIF4
- Transcription factor PIF5
- Transcription factor MYC2
- Protein BRASSINAZOLE-RESISTANT 1
- Gibberellin 3-beta-dioxygenase 1
Sequence:
MKREHNHRESSAGEGGSSSMTTVIKEEAAGVDELLVVLGYKVRSSDMADVAHKLEQLEMVLGDGISNLSDETVHYNPSDLSGWVESMLSDLDPTRIQEKPDSEYDLRAIPGSAVYPRDEHVTRRSKRTRIESELSSTRSVVVLDSQETGVRLVHALLACAEAVQQNNLKLADALVKHVGLLASSQAGAMRKVATYFAEGLARRIYRIYPRDDVALSSFSDTLQIHFYESCPYLKFAHFTANQAILEVFATAEKVHVIDLGLNHGLQWPALIQALALRPNGPPDFRLTGIGYSLTDIQEVGWKLGQLASTIGVNFEFKSIALNNLSDLKPEMLDIRPGLESVAVNSVFELHRLLAHPGSIDKFLSTIKSIRPDIMTVVEQEANHNGTVFLDRFTESLHYYSSLFDSLEGPPSQDRVMSELFLGRQILNLVACEGEDRVERHETLNQWRNRFGLGGFKPVSIGSNAYKQASMLLALYAGADGYNVEENEGCLLLGWQTRPLIATSAWRINRVE
Protein: Large ribosomal subunit protein uL10m (54S ribosomal protein L11, mitochondrial) (YmL11) (P36521)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:9162110}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein mL54
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein mL44
- Large ribosomal subunit protein mL49
Sequence:
MLQLRFMPGWVPRNGFFGLKETIGTVHKRFYALASEQPSRKTVKPLDSRKTFLIDTYKHLMENSSMIFFVHYNNLSKTEDHHFRFKIKQTGGKLTKVRNNLFEVYLRNSHLPDPCGFVKRKEQNWKHPLLPLLKGPTATITYEDTNPQQVAKLLKVLQSAQDKLMVIGAKVENEVLNVEKINTFKTLPTKPEMQSQLVSVLQMLSGLGLVRTLENSSNALYLTLKSHNDNQKPKEDVESTTDAESKGSK
Protein: Dihydroxyacetone kinase 1 (DHA kinase 1) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase 1) (Triokinase 1) (Triose kinase 1) (P54838)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.
Interaction partners:
- Glycerol 2-dehydrogenase
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Triosephosphate isomerase
- Fructose-bisphosphate aldolase
- Dihydroxyacetone kinase 2
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol kinase
- S-formylglutathione hydrolase
- Glycerol-3-phosphate O-acyltransferase 2
Sequence:
MSAKSFEVTDPVNSSLKGFALANPSITLVPEEKILFRKTDSDKIALISGGGSGHEPTHAGFIGKGMLSGAVVGEIFASPSTKQILNAIRLVNENASGVLLIVKNYTGDVLHFGLSAERARALGINCRVAVIGDDVAVGREKGGMVGRRALAGTVLVHKIVGAFAEEYSSKYGLDGTAKVAKIINDNLVTIGSSLDHCKVPGRKFESELNEKQMELGMGIHNEPGVKVLDPIPSTEDLISKYMLPKLLDPNDKDRAFVKFDEDDEVVLLVNNLGGVSNFVISSITSKTTDFLKENYNITPVQTIAGTLMTSFNGNGFSITLLNATKATKALQSDFEEIKSVLDLLNAFTNAPGWPIADFEKTSAPSVNDDLLHNEVTAKAVGTYDFDKFAEWMKSGAEQVIKSEPHITELDNQVGDGDCGYTLVAGVKGITENLDKLSKDSLSQAVAQISDFIEGSMGGTSGGLYSILLSGFSHGLIQVCKSKDEPVTKEIVAKSLGIALDTLYKYTKARKGSSTMIDALEPFVKEFTASKDFNKAVKAAEEGAKSTATFEAKFGRASYVGDSSQVEDPGAVGLCEFLKGVQSAL
Protein: Single-stranded DNA-binding protein WHY2, mitochondrial (Protein WHIRLY 2) (StWHY2) (D9J034)
Organism: Solanum tuberosum (Potato)
Function: Single-stranded DNA-binding protein that may be involved in the maintenance of mitochondrial genome stability by preventing break-induced DNA rearrangements.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
Sequence:
MLKVSRLLHPRNQLLHKKLPGECVKGSIWQHAINTFAGFSTVRQNVVADAGKREGRVFAPYSVFKGKAALSAEPRLPTFNRLDSGGVKLNRRGVIMLTFWPSVGERKYDWEKRQLFALSATEVGSLISMGTRDSSEFFHDPSMLSSNAGQVRKSLSIKPNADGSGYFISLSVVNNNLKTNDRFTVPVTTAEFAVMRTAFSFALPHIMGWDRFTNRPSESISQSPSKVVPQLMEAEWDR
Protein: Mitochondrial distribution and morphology protein 10 (Mitochondrial inheritance component MDM10) (P18409)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
Subcellular location: Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03102, ECO:0000269|PubMed:13679517, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16407407, ECO:0000269|PubMed:19556461, ECO:0000269|PubMed:8089171}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03102, ECO:0000269|PubMed:13679517, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16407407, ECO:0000269|PubMed:19556461, ECO:0000269|PubMed:8089171}. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Interaction partners:
- Sorting assembly machinery 35 kDa subunit
- Maintenance of mitochondrial morphology protein 1
- Mitochondrial distribution and morphology protein 12
- Sorting assembly machinery 50 kDa subunit
- Mitochondrial distribution and morphology protein 34
- Sorting assembly machinery 37 kDa subunit
- Mitochondrial Rho GTPase 1
- Mitochondrial import receptor subunit TOM40
- Mitochondrial import receptor subunit TOM7
- Mitochondrial import receptor subunit TOM22
Sequence:
MLPYMDQVLRAFYQSTHWSTQNSYEDITATSRTLLDFRIPSAIHLQISNKSTPNTFNSLDFSTRSRINGSLSYLYSDAQQLEKFMRNSTDIPLQDATETYRQLQPNLNFSVSSANTLSSDNTTVDNDKKLLHDSKFVKKSLYYGRMYYPSSDLEAMIIKRLSPQTQFMLKGVSSFKESLNVLTCYFQRDSHRNLQEWIFSTSDLLCGYRVLHNFLTTPSKFNTSLYNNSSLSLGAEFWLGLVSLSPGCSTTLRYYTHSTNTGRPLTLTLSWNPLFGHISSTYSAKTGTNSTFCAKYDFNLYSIESNLSFGCEFWQKKHHLLETNKNNNDKLEPISDELVDINPNSRATKLLHENVPDLNSAVNDIPSTLDIPVHKQKLLNDLTYAFSSSLRKIDEERSTIEKFDNKINSSIFTSVWKLSTSLRDKTLKLLWEGKWRGFLISAGTELVFTRGFQESLSDDEKNDNAISISATDTENGNIPVFPAKFGIQFQYST
Protein: Peptidoglycan-N-acetylglucosamine deacetylase PgdA (Peptidoglycan GlcNAc deacetylase) (EC 3.5.1.104) (N-acetylglucosamine de-N-acetylase PgdA) (Peptidoglycan N-deacetylase) (PG N-deacetylase) (Petptidoglycan deacetylase) (PG deacetylase) (A0A3Q0NBH7)
Organism: Listeria monocytogenes serotype 1/2a (strain EGD / Mackaness)
Function: Catalyzes the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan (PG). Deacetylates also N-acetylated PG. Does not deacetylate N-acetylmuramic acid. Confers host lysozyme resistance. Critical for virulence and escape from innate immune response of the host. Required for intracellular survival of bacteria in macrophages of the host. Required for successful host colonization (By similarity). Controls the production of inflammatory mediators in the bone marrow derived macrophages (BMMs) of the infected mouse (By similarity). Suppresses Toll-like receptor 2 (TLR2)-dependent secretion of interleukin 6 (IL-6) and interferon-beta (IFN-beta) in the macrophages of the infected mouse. May decrease accessibility of pattern recognition receptors (PRRs) such as nucleotide-binding oligomerization domain protein (NOD) 1 of the host to the bacterial cell wall components (By similarity). Protects cells from autolysis induced by lysozyme or by other autolysis-inducing agents.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8Y9V5}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8Y9V5, ECO:0000255}; Extracellular side {ECO:0000250|UniProtKB:Q8Y9V5}. Secreted, cell wall {ECO:0000305|PubMed:19809250}.
Interaction partners:
Sequence:
MKIRWIRLSLVAILIIAVVFIGVIGFQKYQFSKSRNKVIMQMDRLMKDQDGGNFRRLDKKENGVEIISYIPKTTEKKDNEIIQKEIGKATDAEVKKLNRDKETQGIIFYTYQKHRMAEQAISYKAVQSEYVKEGRTKFVLKDKKDICKNIVTDAETGALLTLGEVLIKSNQTKLNLKTAVEEELIKTGDFSLKDVGNLGKIKSLVKWNQTDFEITNSEIILPVKIPGAPEPKKVKVKLADIASSVNKRYLPSSVKVPEVPKAKTNKRIALTFDDGPSSSVTPGVLDTLKRHNVKATFFVLGSSVIQNPGLVKRELEEGHQVGSHSWDHPQLTKQSTQEVYNQILKTQKAVFDQTGYFPTTMRPPYGAVNKQVAEEIGLPIIQWSVDTEDWKYRNAGIVTKKVLAGATDGAIVLMHDIHKTTAASLDTTLTKLKSQGYEFVTIDELYGEKLQIGKQYFDKTDSRMVK