wanglab/gogpt-training-data huggingface dataset:
Protein: Transmembrane protein 181 (Q9P2C4)
Organism: Homo sapiens (Human)
Function: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEPLAPMRLYTLSKRHFVLVFVVFFICFGLTIFVGIRGPKVIQTSAANFSLNNSKKLKPIQILSNPLSTYNQQLWLTCVVELDQSKETSIKTSFPMTVKVDGVAQDGTTMYIHNKVHNRTRTLTCAGKCAEIIVAHLGYLNYTQYTVIVGFEHLKLPIKGMNFTWKTYNPAFSRLEIWFRFFFVVLTFIVTCLFAHSLRKFSMRDWGIEQKWMSVLLPLLLLYNDPFFPLSFLVNSWLPGMLDDLFQSMFLCALLLFWLCVYHGIRVQGERKCLTFYLPKFFIVGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGMKVFFMVVAAVYILYLLFLIVRACSELRHMPYVDLRLKFLTALTFVVLVISIAILYLRFGAQVLQDNFVAELSTHYQNSAEFLSFYGLLNFYLYTLAFVYSPSKNALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQAIRAKYKEESDSD
Protein: Emb|CAB71880.1 (Endonuclease or glycosyl hydrolase) (Q9FGG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MQFGSSKTLFFRVAGFSSTSVFKPRRAISVPVGNFSSSSSISAHYTSLKRSQYEEDSRSVRVPVWWDFENCHLPSGANVFKLAQTITSAVRICGIKGPITITAYGDMIQLSRTNQEALFATGINLTHVPQGGKNSTDRSLITEIMCWVSQNPPPAHLFLISSDSDFANVLHRLRMRNYNILLACYEETTLGVLCSAASIMWDWDALVRGQNPTAKHFNQPPDGPYHSWYGHYTTPLLDPFATSTNNKQISSTSVKTVELLELGSSKSRRPIPNKVVKQIGLILRWYPKGAAITELREQLRKRKVLLDRDFYGYKSFSRFLLSMRNILQVVPLGDGMFSIHAVTQGMDNKALLPKVSCENHAVVSVEKMCQNMKQNDKDVKEESHQLQESSQEFVQVMKLMDVKAKEEPVKANQLAITAVDDVSSFEEKDGFLKKLNRLLFGSPEMELEHLQERKHISGNGVLGEGKVVDKDLESQIASSTSSESAEEVKVDNAVGNGKSKSPGLTCRLLKRFKFSWGRYTELSNAAATGPQVDDVFVKDSFWNDVESFINSPRGFVAVSHSRSRETMAKNLKEEGPSSLKPLDVPKMLDLISMLISEKKWIQENPSDALPFRVTRFTEESSCRSNPRTTDGLRAIFVNMSESLCDGANGDKNSTNVGMSQKPKERSRSKVIADCHKLIKKITEENAGGYSITKFKKAFLEKFGYRLEYRKFGFSKLQSLIEMMPEARIESGHIVTSSTPVPCESDSSFEDLGPVSKKIHENESSVSEGEDYDSEMEEKASSKQSGGERKKKEDETESDLLQILGSWDTDKKPAKTFGEDKLVEGILMSLRKKPSGDSRIQD
Protein: Adducin 3 (gamma) a (A0A2R8QBF8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
Interaction partners:
Sequence:
MSGEPRQEVVTTPPPPSVGKREGYFDRVNENDPEYLRARNMSPDLRQDFNMMEQKKRVTQILQSPAFKDELEGMIQEQMNKGNNPTGLLALRQIADFFMSSSVAGFSTSPLSLGMVTPINDMFSVESSTMVKGEKQTRCKLASLYRIVDLFSWAHFASCYITVRVSKEQDHILIIPRGLSFAEASASNLVKVNILGDVIDQGSTNLRIDAAGFSPHAAIYSIRPDVRCIVHISTPATAAVSSMKCGLLPISQEALILGDIAYYNYQGSLDEQEERVELQKALGPTAKVLVLRNHGIVALGETIEEAFHYIYGAQYACEIQVNAFSCAGGMENLIVLDLEKFKARTQGVAQVGVNMGSQQKWRLGELEFESLMRMLDNLGYRTGYTYRHPIVREKPRHKSEVEIPATVTAFMFDEDDAPRFPLKLLQQRQQREKTRWLNSPNCYMKVNVADGASEENRRTKTTWMKSDDGGNASGTPIRIEDPNQFVPLNTNPSEVLQKRNKIREQNRFDVMTAGPQSQKLAGIVVERPPPYMGNDEEETGALPPNPFSELNEKEEHQRRLRIDDEEQLTSDDASTLSQSVSPQHTPAKEENHTGVMLNGKDDHGDEDELIKRVSQLTTSLESMEISVRSGEKIEEALTPESSPSKSPNKKKKKFRTPSFLKKNKKKEKVEA
Protein: (Z)-gamma-bisabolene synthase 1 (EC 4.2.3.40) (Terpenoid synthase 12) (AtTPS12) (Q9T0J9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in sesquiterpene (C15) biosynthesis. The major product is (Z)-gamma-bisabolene with minor amounts of (E)-nerolidol and alpha-bisabolol.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Alpha-humulene/
- Probable alpha,alpha-trehalose-phosphate synthase 9
- (Z)-gamma-bisabolene synthase 2 (Terpenoid synthase 13) (AtTPS13)
- Alpha-barbatene synthase
- Inactive squalene synthase 2
- Squalene synthase 1
- Probable alpha,alpha-trehalose-phosphate synthase 7
- Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 2
- Dehydrodolichyl diphosphate synthase 1
- Dehydrodolichyl diphosphate synthase 4
Sequence:
MESQTTFKYESLAFTKLSHCQWTDYFLSVPIDESELDVITREIDILKPEVMELLSSQGDDETSKRKVLLIQLLLSLGLAFHFENEIKNILEHAFRKIDDITGDEKDLSTISIMFRVFRTYGHNLPSSVFKRFTGDDGKFQQSLTEDAKGILSLYEAAHLGTTTDYILDEALKFTSSHLKSLLAGGTCRPHILRLIRNTLYLPQRWNMEAVIAREYISFYEQEEDHDKMLLRLAKLNFKLLQLHYIKELKSFIKWWMELGLTSKWPSQFRERIVEAWLAGLMMYFEPQFSGGRVIAAKFNYLLTILDDACDHYFSIHELTRLVACVERWSPDGIDTLEDISRSVFKLMLDVFDDIGKGVRSEGSSYHLKEMLEELNTLVRANLDLVKWARGIQVPSFEEHVEVGGIALTSYATLMYSFVGMGETAGKEAYEWVRSRPRLIKSLAAKGRLMDDITDFDSDMSNGFAANAINYYMKQFVVTKEEAILECQRMIVDINKTINEELLKTTSVPGRVLKQALNFGRLLELLYTKSDDIYNCSEGKLKEYIVTLLIDPIRL
Protein: Heat shock factor-binding protein 1 (Q556J3)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- WASH complex subunit 3
- Heat shock factor-type DNA-binding domain-containing protein
Sequence:
MSTNNNNTNSTNPQPQQPQQPQNNGDVLIGNVVQNLLEQMQSRFEKVSESILTRIDEMGQRIDELDKSISDLMLQAQQQKQIQQQQQSQQESSDQNNENQSN
Protein: Tail tube protein (H9C1A3)
Organism: Pectobacterium phage ZF40 (Bacteriophage ZF40)
Interaction partners:
Sequence:
MTMKRYGADGANLTVFGIPIDDFGDTDPPITIEDLESRATLKRGIGKTSVRLDSQTRPKRLTINLIPGSDQVRQILAVEKTGVDATFTFFQTGTEETVMGFDGVLVNRGSMTRGGKTSVSDEQFIFEFADSEET
Protein: Rho GTPase activating protein 30 (A0A0A0MRJ9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGTPQPPQPEEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLLSSQRRSYAFETQANPGKGEGL
Protein: ADP-ribosylation factor-like protein 5A (Q9Y689)
Organism: Homo sapiens (Human)
Function: Lacks ADP-ribosylation enhancing activity.
Interaction partners:
Sequence:
MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR
Protein: Zinc finger protein 593 (A9J4F5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRSRRTGAHRAHSLARQMKAKRRRPDLDEIHRELRPQGSARPQPDPNAEFDPDLPGGGLHRCLACARYFIDSTNLKTHFRSKDHKKRYEGVRRGLMDGCSADRALTWSAPNSCFSFSQAEAAERRALQSGRGGEGSGYGILCAPQAAGSAHGSVH
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (X2JCK2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MDCATRKQQQLRAHHQQQQIQIQTHGRKRQQLQKQRHNHHHYYQNSQQQQKHFVWLVVGILTIFLAQHANAADLVINVPNASSNANAFYRIDYSPPFGFPEPNTTIPASDIGKDIKFSRALPGTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEERQPQTKMGTLPIRASLAMAEKLDADLMTNKDEDEDQEQQQQQQLQLATEVKPKGSNDDEEDEEDDDDDDDDQQPLNNETTATLSSASCSSSTHDVHVVLQEAIEKPKQEQERICAGTQSHADTESDNTDSDDDDEDGDGKVAKDGAVADEDGWWY
Protein: Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2) (Q7LBR1)
Organism: Homo sapiens (Human)
Function: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.
Subcellular location: Cytoplasm, cytosol. Endosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body.
Interaction partners:
- Vacuolar protein sorting-associated protein VTA1 homolog
- Spastin
- Charged multivesicular body protein 3
- Vacuolar protein sorting-associated protein 4A
- IST1 homolog
- Charged multivesicular body protein 2a
- Vacuolar protein sorting-associated protein 4B
- RNF103-CHMP3 readthrough
- Charged multivesicular body protein 4b
- Charged multivesicular body protein 2b
Sequence:
MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
Protein: Ranatuerin-2SEa (P85057)
Organism: Lithobates sevosus (Dusky gopher frog) (Rana sevosa)
Function: Mast cell degranulating peptide. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity against the Gram-negative bacterium E.coli K12 and Gram-positive bacterium M.luteus NCT C2665.
Subcellular location: Secreted {ECO:0000269|PubMed:16386333}.
Interaction partners:
Sequence:
GFISTVKNLATNVAGTVIDTIKCKVTGGC
Protein: Large ribosomal subunit protein uL18 (60S ribosomal protein L5) (P09895)
Organism: Rattus norvegicus (Rat)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P46777}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P46777}. Note=Although RP5 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL5 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. {ECO:0000250|UniProtKB:P46777}.
Interaction partners:
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL24
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS15
Sequence:
MGFVKVVKNKAYFKRYQVRFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVNGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Protein: Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Inositol polyphosphate 4-phosphatase-1) (4-Ptase-1) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) (Q9EPW0)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate. Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current.
Subcellular location: Early endosome membrane {ECO:0000250|UniProtKB:Q96PE3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q96PE3}. Cell membrane {ECO:0000250|UniProtKB:Q96PE3}. Nucleus {ECO:0000250|UniProtKB:Q96PE3}. Cytoplasm {ECO:0000250|UniProtKB:Q96PE3}. Postsynaptic density {ECO:0000269|PubMed:20463662}. Note=Translocates to the plasma membrane upon EGF stimulation (By similarity). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (By similarity). {ECO:0000250|UniProtKB:Q96PE3}.
Interaction partners:
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- Inositol polyphosphate 5-phosphatase OCRL
- Synaptojanin-1
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
- Phosphatidylinositol polyphosphate 5-phosphatase type IV
- Myotubularin
- Synaptojanin-2
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Sequence:
MTAREHSPRHGARARAMQRASTIDVAADMVGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQIKLSVYDVKDRSQGTMYLLGSGTFVVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQQPPVTRFLDTVNGRMVLPVDESLTEALGIRSKYAFLRKDSLLKAVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYKGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDVVTIGAPAAHCQGFKSGGLRKKLHKFEEAKKHSFEECCTSSSGQSIIYIPQDITRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWAGRSSRSSLQVDWHEEEWQKVWLNVDKSLECIIQRVDKLLQKDRLHGEGCEDAFPCSSTCSSKKDCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKAAMVFLLMQDSAPTIASYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDGGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSNASSDMLPVITGNRDGFNVRIPLPGPLVDSFPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEGINGESLVRVNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEVCRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
Protein: Transmembrane protein (O45515)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTAVKRLFFSALNLLGGICILIGVGTPAWLTDDGGSVGIVPFYSTEVGWFAAASWMMFISLSLAVVVSLFTAMLFRDVRRHGYSYTQRSRFFLLAMFALMVTILTVVAVILIGVNLPSFNDYWYDDATLGYSAWVSVAGAVCFFVESGLALSFAFVECNCY
Protein: Glutaredoxin 3 (Q5XJ54)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Together with bola2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O76003}.
Interaction partners:
- Uncharacterized protein LOC553698
- BolA family member 1
- Anamorsin
- Iron-sulfur cluster assembly factor IBA57, mitochondrial
- NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
- Lipoyl synthase, mitochondrial
- LYR motif-containing protein 4
- Frataxin.
- Iron-sulfur clusters transporter ABCB7, mitochondrial
- MMS19 nucleotide excision repair protein homolog
Sequence:
MANFTDAASLQQFDELLKNNSKSLTVVHFHAPWAPQCSQMNDVMAELAKEHKHTMFVKLEAEAVPEVSEKYEITSVPTFLFFKGGEKIDRLDGAHAPELTNKVQRLGSGGGGAVGAGDVPKEDLNQRLKRLINAAPCMLFMKGSPQEPRCGFSRQIIQILKDHNVQYSSFDILSDEEVRQGLKTYSNWPTYPQVYVSGELIGGLDIVKELVESGELENTFPKTVSLENRLKSLINKSPVMLFMKGNKEAAKCGFSRQILEIMNNTGVEYDTFDILEDEEVRQGLKTYSNWPTFPQLYVKGDLIGGLDIVKELLEGGELVSVLKGEN
Protein: Musculin (Myogenic repressor) (O88940)
Organism: Mus musculus (Mouse)
Function: Transcription repressor that blocks myogenesis and activation of E-box dependent muscle genes.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MSTGSVSDPEDSEMRGLQRVYPAPASKRPPLLRMERGYGSPSDISSAEEEDGEEEPGSLGAAGGCKRKRLRGADAGGAGGRAGGAGKKPLPPKGSAAECKQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYEDSYVHPVNLTWPFVVSGRPDSDSKDVSAANRLCGTSA
Protein: Probable thymidylate synthase (TS) (TSase) (EC 2.1.1.45) (Q9UTI7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for both nuclear and mitochondrial DNA synthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Dihydrofolate reductase
- Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
- Thymidylate kinase
- Deoxycytidylate deaminase
- Methylenetetrahydrofolate dehydrogenase [NAD
- Serine hydroxymethyltransferase, mitochondrial
- Probable serine hydroxymethyltransferase, cytosolic
- Probable aminomethyltransferase, mitochondrial
- C-1-tetrahydrofolate synthase, mitochondrial
- C-1-tetrahydrofolate synthase, cytoplasmic
Sequence:
MSQPLHARFATRAVKNPMILEKERQLTDSKYHILVAATGSVAAIKLTLIVKSLLTYKGVDVQVVLTDPARNFVEKEDLTALGVNVYNNADDWKNWDGLECPITHIELRRWAHLLLIAPLSANTMAKMANGLCDNLLTSLIRAWAPLKPILLAPAMNTLMWTNPITQEHLSAISRIYKNSEFIMPIEKVLACGDIGMGGMAEWRNIVGRVADKLQLEQKSVLPNAVKNIDGQDDDSSEQTAAFEEYDDDDDDDVDDNEQSNSMIETSANADITPKASLLPSTTESSISKDHETSQAPLGSESVDTQASENVTTKPEPPVPFTSSEYRNTEEEQYLNLIRYILENGQSRPDRTGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFLRGVLEELLWFIHGDTNANHLSEKGIHIWDGNGSREFLDSRGLTDRKVGDLGPIYGFQWRHFGAQYVDCDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAWNPLAIPEMALPPCHIFCQFYVSEPCKPGGKPQLSSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHVMGDCHIYNDHLEALQTQLERVPKAFPKLFFKRDAKDIGSIDSFSVDDFAVEGYNPYGPIKMKMSV
Protein: LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2) (P50458)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- LIM domain-binding protein 1
- LIM domain-binding protein 2
- Transcription factor COE1
- Cbp/p300-interacting transactivator 2
- Roundabout homolog 2
- Roundabout homolog 1
- LIM/homeobox protein Lhx9
- Homeobox protein MSX-1
- Neurogenin-2
- Homeobox protein SIX3
Sequence:
MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTNLF
Protein: Putative oxidoreductase (A6KWY2)
Organism: Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154) (Bacteroides vulgatus)
Interaction partners:
- Amidohydrolase-related domain-containing protein
- Sorbitol dehydrogenase
Sequence:
MNYNEIGKTGMRVSNLSFGASSLGGVFHDIREAEGIKAVYTAVENGMNFIDVSPYYGHYKAETVLGKALKEIPRDKYYLSTKVGRYGKDGVNTWDYSGKRATESVYESLDRLHIEYIDLINVHDVEFSDMNQVVNETLPALVELKKKGIVGHVGITDLQLENLKWIIDHSEPGTVESVLNFCHYCLNDEKLTDYLDYFESKNIGIINASPLSMGLLSQRGVPAWHPAPQSLVEACRKAVQHCLSKNYPIEKLAIQYSVSNPRIATTLFSSANPDNVLKNITYAEEPIDWNLVKEVQEIIGKQMRISWANS
Protein: ZNF264 protein (Zinc finger protein 264) (Q14C61)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAAVLTDRAQVSVTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLGCPVPKAELICHLEHGQEPWTRKEDLSQDTCPGDKGKPKTTEPTTCEPALSEGISLQGQVTQGNSVDSQLGQAEDQDGLSEMQEGHFRPGIDPQEKSPGKMSPECDGLGTADGVCSRIGQEQVSPGDTVHSHNSCESGKDPMIQEEENNFKCSECGKVFNKKHLLAGHEKIHSGVKPYECTECGKTFIKSTHLLQHHMIHTGERPYECMECGKAFNRKSYLTQHQRIHSGEKPYKCNECGKAFTHRSNFVLHNRRHTGEKSFVCTECGQVFRHRPGFLRHYVVHSGENPYECLECGKVFKHRSYLMWHQQTHTGEKPYECSECGKVFLESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPFVCSECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNRKDLIRHFSIHTGEKPYECVECGKAFTRMSGLTRHKRIHSGEKPYECVECGKSFCWSTNLIRHAIIHTGEKPYKCSECGKAFSRSSSLTQHQRMHTGKNPISVTDVGRPFTSGQTSVTLRELLLGKDFLNVTTEANILPEETSSSASDQPYQRETPQVSSL