wanglab/gogpt-training-data huggingface dataset:
Protein: ELAV-like protein 3 (Hu-antigen C) (HuC) (Paraneoplastic cerebellar degeneration-associated antigen) (Paraneoplastic limbic encephalitis antigen 21) (Q14576)
Organism: Homo sapiens (Human)
Function: RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity).
Interaction partners:
- RNA binding protein fox-1 homolog 3
- ELAV-like protein 2
Sequence:
MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA
Protein: Paraflagellar rod protein (Q580U4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Telomerase-associated protein, putative
Sequence:
MDGYLPNLTRESLNIPTRGISGQNQWRTVRRVCNTASSHDGYKKMLEGVRRQFLEPAYQVPVSRLPDVPVPCRPPPSSSSPGRFSRNLQYTVKDRKIVKKEEEDICSPSLEALEENGRQHIIVNEVWERQVLKQMMIVRYVTFVLRDEIRDLELVEREQRGTIAFEEEKERYWLQHESDASVQLREYKLALSAKREKQKRLQENEALYRARSSSSPFPMNEFKMEPDAQKILQEYLKMKHLADDGEGQPQECPHPPLRRSPQQQRSAERYRRLIGKVSSHNNPPVVRVQPLSNVCNTLGIAAYMGLLEKDSESRKMIEEREEEEYKRIMEHFEEQSSLLLTWKHKRLHLERLIYWKAQSEERRQKEQLRIEMEVLRPRKQMAMPHEELAAQEEEFRNMLGAEEGTRRGDLLQLHNEYFMRTKAKALGNEEMNLRAHILQEDIGVRKLLVQGLEIILRQGICKEWEQNVVMLVPEQIQALAKLNREWIEHEKQILTIQRAVRSFRAGRLGWRITHSEIGRIIQKKRDIAKIDRGKKSLCEYKNYLASEFAAVEEEVRTLHANERNKLFDVEYNSRTIVYTEEEWNRGVLRRTERQDLYDSVIVPLVTNCFSAELDARREIDVEEEFVRGRMCNFFNRLSNIIRTKTYVLGREVEGRAAIEKDENNFFFSILCMELDDRDLVRIMMKEIQAQKEEELFAQALVLLESRKEEEMYMYARLTRLHYEFKREKLEIEALDPNPRALIAHTFLNTALCFFCDESVKFLENYGSLLVEQHSEIVYLCCVAITEEREEEARHLLERLESRAWPEITDCAHREMSSKLRKELRNIGAASRIKIFYRKYRNGDVGRSGMRKHLREAFRVMREKAELKEVFDRQRIDVQECRHNLRDAVAIQSYYTYRRIALELSVVENRAEPRGRSELEGQEEMMFKMILNYFEPPAVPMVDAVTILLHSESHGRIRIKKEWQKAIENDFTRRKEWFEKDVLAIITLRKWQKFAAVKRKRTFIKAELEKLVLSELTQRHELELNETNERFIDIVKPMEYTTHHQAYLDQDVPRFLNEMCFDIGFHLGIKEEEWQNRMLLLWRMRNSYHEKELETEEFATRAALQQSSFYDGVDLIEVVCDESILRAALCDERRYFLMRILARLERASRGDIIHSYDIHSLWMHEYTCRKELYVEYIYSLHHIAPEKNTIQHTKCLLIDAEISHTTEAEESYEKSTNHQPLNDNAEDNNITSSANIVDQTNATPQGPIVDQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKEIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVILEKQIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKEIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKQIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKEIPDTEAAAEQPAEDLTKAGELDEPVADTEVAEKEPTDSEVIPEKEIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVILEKEIPDAEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVILEKEIPDTEAAAEQPAEDLTKAEELDEPAADTEVAEKEPTDSEVIPEKQIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKEIPDTEAAAEQPAEDLTKAEELDEPVADTEVAGKEPTDSEVIPEKEIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKEIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKQIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKEIPDTEAAAEQPAEDLTKAEELDEPAADTEVAGKEPTDSEVIPEKEIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKEIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVILEKEIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKQIPDTEAAAEQPAEDLTKAEELDEPVADTEVAEKEPTDSEVIPEKQIPDTEAAAEQPAEDLTKAEELDEPAADAEVAEM
Protein: Fructose-bisphosphate aldolase 5, cytosolic (AtFBA5) (EC 4.1.2.13) (O65581)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Fructose-bisphosphate aldolase that plays a key role in glycolysis and gluconeogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9SJQ9}.
Interaction partners:
- Triosephosphate isomerase, chloroplastic
- Sedoheptulose-1,7-bisphosphatase, chloroplastic
- Triosephosphate isomerase, cytosolic
- Transketolase-1, chloroplastic
- Transketolase-2, chloroplastic
- Phosphoglycerate kinase 2, chloroplastic
- Glucose-6-phosphate isomerase, cytosolic
- Aldolase-type TIM barrel family protein
- transaldolase
- Fructose-1,6-bisphosphatase 1, chloroplastic
Sequence:
MSAFVGKYADELIKTAKYIATPGKGILAADESTGTIGKRFASINVENIESNRQALRELLFTSPGTFPCLSGVILFEETLYQKTTDGKPFVELLMENGVIPGIKVDKGVVDLAGTNGETTTQGLDSLGARCQEYYKAGARFAKWRAVLKIGATEPSELSIQENAKGLARYAIICQENGLVPIVEPEVLTDGSHDIKKCAAVTETVLAAVYKALNDHHVLLEGTLLKPNMVTPGSDSPKVAPEVIAEYTVTALRRTVPPAVPGIVFLSGGQSEEEATLNLNAMNKLDVLKPWTLTFSFGRALQQSTLKAWAGKTENVAKAQATFLTRCKGNSDATLGKYTGGASGDSAASESLYEEGYKY
Protein: Transcriptional regulatory protein DegU (Protease production enhancer protein) (P13800)
Organism: Bacillus subtilis (strain 168)
Function: Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation, biofilm formation, and competence for DNA uptake. Positively or negatively regulates expression of many different genes. The phosphorylated form is required for synthesis of degradative enzymes, flagellum formation and biofilm formation. The unphosphorylated form is required for expression of genetic competence, via induction of comK.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Signal transduction histidine-protein kinase/phosphatase DegS
- Response regulator aspartate phosphatase H
- Regulatory protein RapG
- Sensor histidine kinase YhcY
- Sensor histidine kinase LiaS
- Sensor histidine kinase LnrJ
- Sensor histidine kinase ComP
- Sensor histidine kinase YxjM
- Sensor histidine kinase YdfH
- Sensor histidine kinase YvfT
Sequence:
MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARIVEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARGYLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIRRPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVVVAIKNGWVEMR
Protein: Putative apoptosis-inducing factor 1, mitochondrial (DmAIF) (EC 1.6.99.-) (Q9VQ79)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable NADH oxidoreductase (By similarity). Mitochondrial effector of cell death that plays roles in developmentally regulated cell death and normal mitochondrial function.
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:18309327}.
Interaction partners:
- Sulfite oxidase, mitochondrial
Sequence:
MSIWGVRCLTQRFIRQAYILANRRLLGPVPQRSPPAYAPLRPAHSSLYQMVKKRTLEARTKLQANKYPNHQVCVTKPSTTPPVEEYETAVEGAGVPAYANAQFQAHSQSEPLFKVGFADVKSVCSAKDVLKSDSAKLSTSQPVLDSCKATSPCEEFKRKRKETTCQPCDEDGTAPGGGDGGDEECECRMKDLRLKCLLGALAALLAGGFLAWFMTRDTDDSEAKKAEAEEEERKRRLVAGLATSPPSSEDLPKHVPYLIIGGGTAAFSAFRAIKSNDATAKVLMISNEFRKPYMRPPLSKELWYTPNPNEDPIKDYRFKQWTGSERSLFFEPDEFFIDPEDLDDNANGGIAVAQGFSVKKVDAQKRIVTLNDGYEISYDECLIATGCAPKNLPMLRDAPPSVLEKVMVYRTPDDFDRLRKLAAEKRSITIVGNGFIGSELACSLAHYSRENNGGKVYQVFQENANMSKVLPNYLSRWTTAKMEAQGVCVIPNASIRSAVRDETNLKLELNNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSLGGFVVNAELEARRNLYVAGDASCFFDPLLGRRRVEHHDHSVVSGRLAGENMTGAKKPYQHQSMFWSDLGPEIGYEGIGLVDSSLPTVGVFALPSESATRVDQLSESSDSDVPETSTSSSQSSKSDAGASQDGVTCDPDEAGNYGKGVIFYLKNDKIVGILLWNLFNRIGLARTIINQNKKYDDLNEVAKLFEIHA
Protein: Kappa-theraphotoxin-Scg1a (Kappa-TRTX-Scg1a) (SGTx1) (SGTx) (SgTx-I) (P56855)
Organism: Stromatopelma calceatum griseipes (Feather leg baboon tarantula) (Scodra griseipes)
Function: Reversibly inhibits potassium currents in oocytes expressing Kv2.1/KCNB1 channels (Kd=2.7 uM). Acts by shifting activation of the channel to more depolarized voltages. The toxin may bind to the S3b-S4 helices of the voltage sensor paddle. One, two, three or four toxin molecules may bind the Kv2.1/KCNB1 channel. It shows low to moderate affinity for lipid bilayers. It partitions into the bilayer membrane, where it stabilizes at the water/membrane interface.
Subcellular location: Secreted {ECO:0000269|PubMed:10504388}.
Interaction partners:
Sequence:
TCRYLFGGCKTTADCCKHLACRSDGKYCAWDGTF
Protein: Keratin, type I cytoskeletal 24 (Cytokeratin-24) (CK-24) (Keratin-24) (K24) (Type I keratin-24) (Q2M2I5)
Organism: Homo sapiens (Human)
Interaction partners:
- Homeobox protein MOX-1
Sequence:
MSCSSRASSSRAGGSSSARVSAGGSSFSSGSRCGLGGSSAQGFRGGASSCSLSGGSSGAFGGSFGGGFGSCSVGGGFGGASGSGTGFGGGSSFGGVSGFGRGSGFCGSSRFSSGATGGFYSYGGGMGGGVGDGGLFSGGEKQTMQNLNDRLANYLDKVRALEEANTDLENKIKEWYDKYGPGSGDGGSGRDYSKYYSIIEDLRNQIIAATVENAGIILHIDNARLAADDFRLKYENELCLRQSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNHEEEMKNMQGSSGGEVTVEMNAAPGTDLTKLLNDMRAQYEELAEQNRREAEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQLAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLDGEGGGSSFAEFGGRNSGSVNMGSRDLVSGDSRSGSCSGQGRDSSKTRVTKTIVEELVDGKVVSSQVSSISEVKVK
Protein: Pleckstrin homology domain containing, family A member 5 (E9Q6H8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAADLNLEWICSLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNDQTVATMTSEDKKERPISMINEASNYNMASDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIAMLTAEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITTDSASTKETNNIPNHRVLIRPEVQNHQKNKEISKIEEKRALEAERYGFQKDGQDRPLTKINSVKLNSLLSEYESGPDCPPQNVHYRPINVNSSDGKAVNVSLADVRGGSHPNAGPLATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRAQILARCPEGYRTLPRNSKTRPESICSVTSSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPRHGCLSSPKAMVQVSDQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEVTSPIQRGDVTIDRRHRPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRTPEELTLLLIKLRRQQAELSSVREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKNKISLYCLSQDECRGTLYKYRPEEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRDQMQGQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETGLAGSKPFSSVKYKSEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEDKKIHQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSETEAPVVKGSHFPVGVPLRTKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLERIRRHQQACLREKKKGLSVLGASDPSDVRDSPLRLTQTLRRDDNVKELDTVHRENDVKPDYETPAAQCAHLEDAEPQNADIGRKLKRSEMLYTPEPNGMASEEVTEKERQKEQVHADGSCSPQEETAMTEHQMEGPPEEAESLHEEEETLASCEPAPEIPRENQTTVRSLSPSPDSSTAADPPTPPQLREGSHFMCV
Protein: YY1 transcription factor (F1NHV6)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone deacetylase 1
- Enhancer of zeste 2 polycomb repressive complex 2 subunit.
- INO80 complex subunit C
- RuvB-like helicase
- Actin-related protein 8
- Uncharacterized protein.
- Actin-related protein 5
- Uncharacterized protein.
- NFRKB_winged domain-containing protein.
- Lethal
Sequence:
MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGGEEDEEEEDEDECCEDCGPHHPPHHYHHHQPMIALQPLVSDGDPSGAGGGAAGGGGGQLHLHHHHQEVILVQTREEVVGGDDSDGLRADDGFEDQILIPVPAPAGEDEYIEQTLVTVAAAGSKSGGGGSSSAGGGGRVKKGGSGKKSSKKSYLSGGGGGGAEGGGGRKWEQKQVQIKTLEGEFSVTMWASDDKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ
Protein: ER membrane protein complex subunit 8/9 homolog (Q9W1Y1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized multi-pass membrane proteins like rhodopsins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:31263175}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43402}; Cytoplasmic side {ECO:0000250|UniProtKB:O43402}.
Interaction partners:
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 7
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 6
- Membrane magnesium transporter
- arginine kinase
Sequence:
MCDYKVSERAYAKLIFHAAKYPHQAVNGLLLAEKTSKGSQVEIVDAIPLFHQCLYVTPMAEVALMLIDAHAEREGLVIAGYYAAPENFYDNQVDKTPAAKIADKIQENFKNACFVVVDNKLMTLQHDRAAIQVFNCPGDSGARWSKAKFTLSQASDTLEGVSLLLKRGAMRDLVDFDNHLDNPDKNWTNDFLNQPLNDLQKLY
Protein: Chromosome-partitioning protein ParB (P0CAV8)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Function: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.
Interaction partners:
- Chromosome partitioning protein ParA
- MipZ
- PopZ
- Chromosomal replication initiator protein DnaA
- Cell division protein FtsZ
- Ribosomal RNA small subunit methyltransferase G
- DNA translocase FtsK
- ParA family protein
- Chromosome partition protein Smc
Sequence:
MESVVVGEPGMSEGRRGLGRGLSALLGEVDAAPAQAPGEQLGGSREAPIEILQRNPDQPRRTFREEDLEDLSNSIREKGVLQPILVRPSPDTAGEYQIVAGERRWRAAQRAGLKTVPIMVRELDDLAVLEIGIIENVQRADLNVLEEALSYKVLMEKFERTQENIAQTIGKSRSHVANTMRLLALPDEVQSYLVSGELTAGHARAIAAAADPVALAKQIIEGGLSVRETEALARKAPNLSAGKSKGGRPPRVKDTDTQALESDLSSVLGLDVSIDHRGSTGTLTITYATLEQLDDLCNRLTRGI
Protein: WD repeat-containing protein srw1 (Suppressor of rad/wee1) (O13286)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in cell differentiation and cell cycling by negatively regulating cig2 and cdc12-associated cdc2. Down-regulates the level of cdc13, particularly in a nitrogen deprived environment. Regulator of cell cycle G1 phase progression. Prevents onset of mitosis during the pre-Start G1 period. Required for degradation of cdc13 mitotic cyclin B during G1 arrest but not during mitotic exit.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- G2/mitotic-specific cyclin cdc13
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin cig2
- Serine/threonine-protein kinase plo1
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit cut9
- Anaphase-promoting complex subunit 3
- Cyclin-dependent kinase inhibitor rum1
- Tyrosine-protein phosphatase CDC14 homolog
Sequence:
MDEFDGFTRPTSSNSSANRNSNNSMNRVENNNSNSDSANTVDSRGDAHTRMRQGFEKSFPSSPNKKRPRTNEGDRFIPSRDASTELWTGFTKVEGPLTPVKKKQSVADRNFTTLLRSELFGSNDETFNNSPIATPNTTIGVSTPRTDSGIDDIELTQRTPPSSSHTSSSILQNTPVTPSRKIFHYLSPRDRNKSSYGKKAQYQDNPNRTIYSLSPVRSITKDLISASRLEGRELPSIPYRVLDAPGLAGDFYLNLLDWGQCNMLAVALASRVYLWSGISSEVTVMHNFYPTDTVTSLRWVQRGTHLAVGTHNGSVEIWDAATCKKTRTMSGHTERVGALSWNDHVLSSGGRDNHILHRDVRAPEHYFRVLTAHRQEVCGLEWNSNENLLASGGNDNALMVWDKFEEKPLYSFHNHIAAVKAITWSPHQRGILASGGGTADRTIKLWNTQRGSMLHNIDTGSQVCNLLWSKQTNEFISTHGFMENEVALWNYPSVSRVGTLKGHTDRVLYLAMSPNGENIVTGAADETLRFWKLFDSKSKHSASTMSSPFDPTMKIR
Protein: Glutathione synthetase large chain (GSH synthetase large chain) (GSH-S) (EC 6.3.2.3) (Glutathione synthase large chain) (Phytochelatin synthetase) (P35669)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Glutamate--cysteine ligase
- Putative glutamate--cysteine ligase regulatory subunit
- Glutathione hydrolase proenzyme 1
- Cys-Gly metallodipeptidase dug1
- Glutathione reductase
- Glutathione hydrolase proenzyme 2
- Putative aminopeptidase C13A11.05
- Glutathione S-transferase 1
- Glutathione S-transferase 2
- Glutathione S-transferase 3
Sequence:
MEIEKYTPEQIEELGKGARDFAFAHGVVFTELSVSKEGRNIATQIPITLFPSVIPHGAFVEAVSVQKAYNKLYAKIANDYEFLRLHLQSITKYDEFMNKLWNLYQKHREAVAHLKENQFQPLSLGVFRSDYMVHQDDSFIGCKQVEFNTISVSFGGVSKAVSNLHAYCSQSGLYRKPLTTNYLTVNTSVSGICTGISNAVDAYRDYVKNITSKMNIASDNTKPIVLFVVKGGERNITDQRTLEYELLNRFHVISKRIDIAELNSLIHDKSSNKLYMKTSFTTYEVAVVYYRVGYALDDYPSQEAWDMRLTIENTLAIKCPSISTHLAGSKKIQQVLAESNALERFLEGDELQAVRSTFADMYPLDDTPRGKEGIKLAFEKPEDFVLKPQREGGGNNTYGKDIPGLLSKMPQEEWDSYILMRYINAVPSQNYILKGERPEKFDVVDEIGILGTIVWNIKTDEVVQNGQSGFICRTKPKKTNEGGVATGYASLSSIELSE
Protein: Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36 (NURP36); Neuromedin precursor-related peptide 33 (NURP33); Neuromedin-U-25 (NmU-25)] (P48645)
Organism: Homo sapiens (Human)
Function: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
Subcellular location: Secreted.
Interaction partners:
- Neuromedin-U receptor 1
- Neuromedin-U receptor 2
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Galanin peptides
- Growth hormone secretagogue receptor type 1
- Neurotensin/neuromedin N
- Neurotensin receptor type 1
- Pro-neuropeptide Y
- Appetite-regulating hormone
Sequence:
MLRTESCRPRSPAGQVAAASPLLLLLLLLAWCAGACRGAPILPQGLQPEQQLQLWNEIDDTCSSFLSIDSQPQASNALEELCFMIMGMLPKPQEQDEKDNTKRFLFHYSKTQKLGKSNVVSSVVHPLLQLVPHLHERRMKRFRVDEEFQSPFASQSRGYFLFRPRNGRRSAGFI
Protein: D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) (P21917)
Organism: Homo sapiens (Human)
Function: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:1319557, ECO:0000269|PubMed:16423344, ECO:0000269|PubMed:1840645, ECO:0000269|PubMed:20100572, ECO:0000269|PubMed:27659709, ECO:0000269|PubMed:29051383, ECO:0000269|PubMed:7512953, ECO:0000269|PubMed:7643093, ECO:0000269|PubMed:8078498, ECO:0000269|PubMed:9003072}; Multi-pass membrane protein {ECO:0000269|PubMed:20100572, ECO:0000269|PubMed:29051383}.
Interaction partners:
- Sodium-dependent serotonin transporter
- Sodium-dependent dopamine transporter
- D
- Catechol O-methyltransferase
- Amine oxidase [flavin-containing] A
- Guanine nucleotide-binding protein G
- Kelch-like protein 12
- Neurotrophic factor BDNF precursor form
- D
- Guanine nucleotide-binding protein G
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
Protein: Short transmembrane mitochondrial protein 1 (E0CX11)
Organism: Homo sapiens (Human)
Function: Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly. Required for the formation of mitochondrial supercomplexes (SCs). Also required for the activation of the NLRP3 inflammasome (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:35450818}; Single-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P0DP99}; Single-pass membrane protein {ECO:0000255}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P0DP99}.
Interaction partners:
Sequence:
MLQFLLGFTLGNVVGMYLAQNYDIPNLAKKLEEIKKDLDAKKKPPSA
Protein: Transportin-1 (AtTRN1) (Importin beta-2) (Karyopherin beta-2) (Q8H0U4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the glycine-rich RNA-binding RBG7 and mediates its nuclear import.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000269|PubMed:14756317}. Note=Shuttles continuously between the nucleus and the cytoplasm.
Interaction partners:
- Importin beta-like SAD2
- RNA binding
- ARM repeat superfamily protein
- GTP-binding nuclear protein Ran-1
- Glycine-rich RNA-binding protein 7
- Heterogeneous nuclear ribonucleoprotein 1
- GTP-binding nuclear protein Ran-2
- GTP-binding nuclear protein Ran-3
- GTP-binding nuclear protein Ran-4
- Transportin MOS14
Sequence:
MAATAVVWQPRDDGLAEICSLLEQQISPSSVVDKSQIWKQLQHFSQFPDFNNYLVFILVRAEGKSVEVRQAAGLLLKNNLRGAYPSMTQENQKYIKSELLPCLGAADRNIRTTVGTIISVIVNIEGVSGWHELLPALVTCLDSNDLNHMDGAMDALSKICEDIPHVLDTEVPGLAERPINIFLPRLLQFFQSPHASLRKLALGSVNQYIIIMPAALYNSLDKYLQGLFVLANDPVPEVRKLVCAAFVHLTEVLPSSIEPHLRNVMEYMLQVNRDPDEEVSLEACEFWSAYCDAQLPPENLKEFLPRLIPVLLENMAYADDDESLLDAEEDESQPDRDQDLKPRFHTSRLHGSEDFDDDDDDSFNVWNLRKCSAAAIDVLSNVFGDEILPALMPLIQKNLSASGDEAWKQREAAVLALGAIAEGCMNGLYPHLSEIVAFLLPLLDDKFPLIRSISCWTLSRFGKYLIQESGNPKGYEQFEKVLMGLLRRLLDTNKRVQEAACSAFATVEEDAAEELVPHLGVILQHLMCAFGKYQRRNLRIVYDAIGTLADSVREELNKPAYLEILMPPLVAKWQQLSNSDKDLFPLLECFTSISQALGVGFAPFAQPVFQRCMDIIQLQQLAKVNPASAGAQYDREFIVCSLDLLSGLAEGLGSGIESLVQQSNLRDLLLNCCIDEAADVRQSAFALMGDLARVFPVYLQPRLLDFLEIASQQLSANLNRENLSVANNACWAIGELAVKVRQEVSPIVAKVVSSLGLILQHGEGVNKALVENSAITLGRLAWIRPDLVAPHMDHFMKPWCMALSMVRDDIEKEDAFRGLCAVVKVNPSGGVSSLVFICQAIASWHEIRSEDVQTEVSQVLNGYKHMLGNSWAECLSALDPPVKERLARYQV
Protein: [histone H3]-dimethyl-L-lysine(36) demethylase (EC 1.14.11.27) (F6P9Q3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- S-phase kinase-associated protein 1
- E3 ubiquitin-protein ligase RING2
- Histone H3.2
- Histone H3
- Zinc finger protein 1007.
Sequence:
MEACAESGRKLRSICRRMYDENEDLSDVEEITNVRGFSLEDKLDSASYNSQLVQFMEGKDFTYEYVQREALRTPLVFKAKDGLGIRMPDPEFTVSEIKGLVGSRRPVDVMDVSTQKGSEMSMAQFVRYYETPEDERDKLFNVISLEFSHTKLENLIKRPTVVDLVDWVDNMWPRHLKQKQTEATNVMSEMKYPKVQRYCLMSVKGCFTDFHIDFGGTSVWYHVFKGQKVFWLIPPNAHNLSLYEDWVLSGKQSDIFLGDRADGCQRVELKQGYTFFIPSGWIHAVYTPEDTLVFGGNILHSFNIPMQLTVYEIENRTKVHSKFRYPFFYEMCWYVLERYVSCLTKRSHLSLEFRNHTAEPKPVTESLMSATRLDMEEDSCGTEGTILSSFSIPPCQTFKPSANDSEDSSKSLPSECPKTPSGSPGMDHSGKWSHLTEFELNGLKALVEKLESLPENKKCVPEGIEDPQALLDDVKVVLKEHADDNPKLAISGSPIVCWPKKTFKPRPLNRPKPKMGSSPCAAPGSTAGGMKLSSGRGSSSARRRRTRCRKCEACTRKECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCVVCGEAGKEDTVEGEDDKFSMMLMECSICSEIIHPACLKDKDAGGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQRTLIKEEPDMSTETTAVSPITKRKTEHEDNPTCKSEDALKKRSPKLEDNPLRKKRKLFEKDSDSNSIIRKKKKRTNPDDLSTSLILGHIKKEREDDEEYEEQNQPERSFVPSEEEDGDDERDEEEEEKALSSRKENGKVSHKTLESDQSQGGLTQAGPSSTDAQSKSQRKPKRKPRLPNKELSKELSKQLNQEIQKTEDRLAHQNGRTVKTEPSSDGEDRKPLNNGSSHLRDWLGPKWELNGSLREQTPVSLIRTTTPAPVFRPTPCRSPPKCVQMERHVIRPPPISPPPDRLPLDDGKNHVLRREVWMGVFSHLIHKDLCVCMSVCKTWNRWCCDKRLWTKIDLNRCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRVLLLAGCSWAAVSALCTSSCPLLRNLDVQWVEGLKDNQIRDLLSPPTDNRPGQLDCRSKLRNVEDLCLAGLDITDTSLKLIIKHMPLLSQLDLSYCNHITDQSVNILTAAGTTTRDSLTHINLSVCNRVTDLSLTYFKRCGNICQIDLRYCKQVTKEGCEQFIAEMSVSVQFRLMEEKLLSKLS