wanglab/gogpt-training-data huggingface dataset:
Protein: Intraflagellar transport protein 172 (Q5DM57)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Required for the maintenance and formation of cilia and participates in the control of flagellar assembly/disassembly at the tip. Involved in regulating the transition between anterograde and retrograde intraflagellar transport at the tip.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17326139, ECO:0000269|PubMed:9585417}.
Interaction partners:
Sequence:
MQLRYFKSILPPADQYQKITSLTWAPNNSRLAAVSTDKVVYLFDENGEKRDKFKTKAAEANNPNTYIIRAMAFSPDSTKLAIAQSDNIVFIYRLVDPDTGAEKKSICNKFPQACAVTSLVWPKDRPNEVVFGLADGKVRLGMLKNNKSYTCYAHPENSYVVALASSLNGQNVISGHMDGAIWKFNFPAEEGGTPTSSQLVVHSCVPYSLGWGSCIAAAGNDNRVVFYDLNGREIRSFDYSNNDEVREFTTCAFNPSGDTVVFGTYNRFYMYTFNIQRNDWEEAGHKQIDNFYAVSAASWKPDGSKMTVGSMTGAVDMYDACVKRHMYKGKFEFTYVSKSAVIVKTLKTGMRIVLKSVYGYEIEKINIYHDRYLIARTTYTLLMGDLDTCKLSEIPWDSDGSEKFHFENERVCMVHYAGELHIVEYGRNDVLGTCRTEHMNPYLISAVVQEARGIASESKKLAYLIDLQTVRIQDLMAPVGSTLATVNHDTKVDWLELNQRGTHLLFRDKKRHLHLFSLSGQERTTLLNYCQYVQWVPGSDVIVAQSRNNLCVWYSVNKPDNVTMFPIKGEVVDIERHNHRTEVIVDEGINTVSYALDEALIYFGAALEDQDYERAVQTLEPLELTPETEAQWMQLAEQALATNQLVIAERCYAALGDIAKSRFLHKVVKKAQQAAKEFGGDGTDAWSVRAMMAQLNKQWPVSESLLLAQGKVDDAITLYQDNHRWEDAIRVADSTHHANAAALKQQYLTWLLETGQEEQAGAVKEREGDYLAAIGLYLKGGLPGRAAQVVMSVHNVNWDPALLDSILASLAKAGLYERAGELYEHMSRSSEAMQSYRRGHAYRKAIDLARREFPAEVIIIEEEWGDWLVTQKQMDAAINHFIESGATLKAIKAAIDCRQFAKAAGIIEVLDPREAMPYFRRIAQHYETTGALEEAERYYIRADMARDAVEMYSRAGKWEAAQRVARGYLTESEMRAFYRAKAAEFEAAHKLKEAEKAYLAAGGDDVDKAIAMYKRNKMYDQMIRLVTQYRKEKVPEAHTLIAQQLEVEGNLREAEKHFVEAKDWKSAVQMYRQVNQWEDALRVAKVYGGVNASKQVAYAWALTLGGDDGAQLLKKMGLLDHAIEYAVESGAFAQAFEMTRAGAKHKLPEVHLKYAMFLEDEGRFAEAEAEFISAGKPKEACDMYMHNQDWDAAMRIAERYDPTMVSEILVSQARVAVERKQWLPAEGLFIKAKRPEAALKMYRDARMWNDALRVAEQYLPTKVAEVQMELLSGQGAGGGSGGASADAVINKARGFERNNDYARAIETYLSLTAQDTSNQDQLEHCWGQAAQLAINYQRHRMKDVVNTVSERLQEIGRHQAAGELHESIDDAQGAIRAYCAGRLWDKARTLAGTNPTFSRYIEDQYNNYLLQNQQADELASRGGQHAQQAIEMYVARDEWAKVHELAAQQGPEVASNYALKHAERRFKQGDYAQAAQVFAQHGITAQPQYFELYKSIAQGVLHASQGDRNPVAEKSLRDMMYRLVNVLRSGGGAGKYKVDTDAFQNYYLAAHYLTCAAAAKEQGLKDIAAMNLTSVLRYVGPTIPADRAFYEAGLAWYEAGRKNMAFVMLNRFLDLSDAMDEPDSSAAVIENADFSDTDIPYDFTIPERAYCTESQREDVRNLVLEISMDRSSDQSLALKACEHCGKPTYEANLTCHFCKKKYDPCVVTGYPIQSYDRVVFKNNGPELNAIRDMWNKWVEAFGTDPVTGMQAAPMY
Protein: Probable carboxylesterase 1 (AtCXE1) (EC 3.1.1.1) (Q9LMA7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carboxylesterase acting on esters with varying acyl chain length.
Interaction partners:
- Probable carboxylesterase SOBER1-like
- LanC-like protein GCL2
- Methylesterase 18
- Methylesterase 4
Sequence:
MDSEIAFDYSPRFRIFKNGGIERLVPETFVPPSLNPENGVVSKDAVYSPEKNLSLRIYLPQNSVYETGEKKIPLLVYFHGGGFIMETAFSPIYHTFLTSAVSATDCIAVSVEYRRAPEHPIPTLYEDSWDAIQWIFTHITRSGPEDWLNKHADFSKVFLAGDSAGANIAHHMAIRVDKEKLPPENFKISGMILFHPYFLSKALIEEMEVEAMRYYERLWRIASPDSGNGVEDPWINVVGSDLTGLGCRRVLVMVAGNDVLARGGWSYVAELEKSGWIGKVKVMETKEEGHVFHLRDPDSENARRVLRNFAEFLKEETF
Protein: Bromodomain-containing protein 2 (H0Y6K2)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XNGGGGSATARGGEYRLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
Protein: Eukaryotic translation initiation factor 4E allele Eva1 (eIF4E-Eva1) (eIF-4F 25 kDa subunit) (eIF-4F p26 subunit) (eIF4E-1 variant 1) (mRNA cap-binding protein) (R4HYA4)
Organism: Solanum etuberosum (Wild potato)
Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity). Key component of recessive resistance to potyviruses.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:K0P2S0}. Cytoplasm {ECO:0000250|UniProtKB:K0P2S0}.
Interaction partners:
Sequence:
MAAAEMERTTSFDAAEKLKAADAGGGEVDDELEEGEIVEESNDAASYLGKEITVKHPLEHSWTFWFDNPTARSRQIDWGSSLRNVYTFSTVEDFWGAYNNIHHPSKLVMGADFHCFKHKIEPKWEDPICSNGGTWKMSFSKGKSDTSWLYTLLAMIGHQFDHGDEICGAVVNVRVKGEKIALWTKNAANETAQVSIGKQWKQFLDYSDSVGFIFHDDAKRLDRNAKNRYTV
Protein: Utp8p (A0A1D8PIX3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Utp4p
- SnoRNA-binding rRNA-processing protein
- Utp18p
- SnoRNA-binding rRNA-processing protein
- rRNA 2'-O-methyltransferase fibrillarin
- Utp9p
- Utp13p
- Utp5p
- rRNA-processing protein
- Nan1p
Sequence:
MSKPELYDQYMITTLPRTPDLELSDKVVVSTIKSIDTSIIDIGVSKSTISSHITKPTPKLLWSYSLNPTTIVECMDVLAKEDKKYYVCGLSDRKKFRLLLVETTRSITEDGNANYTTTNELELKLDRKPIGIKFMSPEIITVLYVNGSVEEVGFSENILQFSGVKYTGTKSKDTVVYSAFVNDLEDNLLLTVSTNSKSTIYRLIAINSKNSILEVNSHSVPGVSNTKFCYFTGSLYQYANKAIETLSITNFKITNTVSVDGIINDEEITSIVAPAPDRVLIGNSNMIYLINVKFASLLSSFKSSSSSSHPIPDKVFLNQVVPVKGNSTNSYISMAVYLNLKNKDNNVYLNVIDINVGMNKLSECLGKSLNKQKPGFHEIPELFNIQDALPSSDEIQEVYSYLKDAKEAQDLNKWESILIPYLKNKKTWAEIKSLSRASKKDKVYEFKEFDVDNDRVIDIGFIDSVLQLIFTEDPLAFANEQFVPEYTLMYLLTNPLFPIRFTSGLIELFSVTGNTTLLRQAINTCPNIPCRDLLDQLVNEENKETLLDLINRIIGEFSRKEITNTFKQLIQGNAVDVVELISKLIGLPGNNNWYLVEILVDVNGLFNWDMGDIKALDEIISQKVEALTVNSYNLTLSHQVLLHNKRLSKKAKEKGSTSHLDNLLTLTSHSTSAKFDDTPEEANLKVPVYSVERVNF
Protein: TSC complex subunit 1 (A0A2R8YFV7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHILTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADTQNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPTSPGNVPPDLSHPYSKVFGTTGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPRKEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELNKLPLPSKSVDWTHFGDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQRLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKTPRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHPSPPTPDSVGQLHIMDYNETHHEHS
Protein: Peptide chain release factor RF1 (RF-1) (P0A7I0)
Organism: Escherichia coli (strain K12)
Function: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
Subcellular location: Cytoplasm.
Interaction partners:
- Release factor glutamine methyltransferase
- Ribosome-recycling factor
- Large ribosomal subunit protein bL27
- Large ribosomal subunit protein bL20
- Peptide chain release factor RF3
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein bL17
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL3
Sequence:
MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE
Protein: HIT-type domain-containing protein (Q386M1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTGMLRCIICAGNSAHYRCRQCRSMYCSLNCFKEHRDGSGVGSCSYEQQQLKEPKDGGGEDVVAKKPKLDSSRDGYITVCTEPTTGNSSTMEEQKELDCSAGARRSDDYSVYGRRDEDGSLVVLGEAHLAALARDAKLRNQLRSAELQRLLRIVNISRSRVDALEAALANVPEFKGFCENVLEVLGRVDVNFNS
Protein: Atypical chemokine receptor 1 (Duffy antigen receptor for chemokines) (Duffy antigen/chemokine receptor) (Duffy blood group antigen) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234) (Q16570)
Organism: Homo sapiens (Human)
Function: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Subcellular location: Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Interaction partners:
- Interleukin-8
- Tumor necrosis factor receptor superfamily member 14
- Nectin-1
- C-C motif chemokine 2
- C-C motif chemokine 5
- Growth-regulated alpha protein
- Nectin-2
- CD82 antigen
- C-X-C motif chemokine 5
- Tumor necrosis factor ligand superfamily member 14
Sequence:
MGNCLHRAELSPSTENSSQLDFEDVWNSSYGVNDSFPDGDYGANLEAAAPCHSCNLLDDSALPFFILTSVLGILASSTVLFMLFRPLFRWQLCPGWPVLAQLAVGSALFSIVVPVLAPGLGSTRSSALCSLGYCVWYGSAFAQALLLGCHASLGHRLGAGQVPGLTLGLTVGIWGVAALLTLPVTLASGASGGLCTLIYSTELKALQATHTVACLAIFVLLPLGLFGAKGLKKALGMGPGPWMNILWAWFIFWWPHGVVLGLDFLVRSKLLLLSTCLAQQALDLLLNLAEALAILHCVATPLLLALFCHQATRTLLPSLPLPEGWSSHLDTLGSKS
Protein: T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta-1) (P80317)
Organism: Mus musculus (Mouse)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P40227}.
Interaction partners:
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit theta
- Heat shock 70 kDa protein 1B
- Chaperonin containing TCP1 subunit 8-like 1
- Heat shock 70 kDa protein 1-like
Sequence:
MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIRKKDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGIALNSFDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLVKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVALAEALIKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLSTGEPMVAAEMGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG
Protein: Beta tectorin (Beta-tectorin precursor) (Tectorin beta) (Zgc:101843) (Q5PR99)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Otogelin.
- Otogelin-like.
- Otolith matrix protein 1
Sequence:
MAAVGLFFILLPVTWACAPQKADYVMVSCFPNAIIANVPECPYGWEIGQLSLGGVCYTGINTPGFYRFTIPDLTPKNHSYCGTLSEYVGGKDPRYIFYNSIVSNDSSLTVRNQPVNYTFSCTYKAAYLVNNAVFSQRVATVYVNNGSLGSFKSQLSMNVFTNSKFLYAKDAPYVIDTSEIGSEVFIGIEAKGLSNRFKVVITNCWATPTPYSTDRKRWTLIQNSCSLDNTVTIFENAKDSRSMFKFNSFRFQRLEKVSTVWLHCEVQVCDGEKLFCQPTPCTSRSTEFEPDPNGGILTMEFQVRAQHSSSYIHPAGPFLCLLSILLLNEFLGYFTF
Protein: AT4G17730 protein (Syntaxin of plants 23) (A8MS65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSFQDLEAGRGRSLASSRNINGGGSRQDTTQDVASGIFQINTSVSTFHRLVNTLGTPKDTPELREKLHKTRLYIGQLVKDTSAKLKEASETDHQRGVNQKKKIVDAKLAKDFQAVLKEFQKAQRLAAERETVYAPLVHKPSLPSSYTSSEIDVNGDKHPEQRALLVESKRQELVLLDNEIAFNEAVIEEREQGIQEIQQQIGEVHEIFKDLAVLVHDQGNMIDDIGTHIDNSYAATAQGKSHLVRHQRHKDQILLCLISPSS
Protein: Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2) (Q8NC67)
Organism: Homo sapiens (Human)
Function: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Glutamate receptor ionotropic, kainate 2
- Lysine--tRNA ligase
- Solute carrier family 12 member 5
- Glutamate receptor ionotropic, kainate 1
Sequence:
MALERLCSVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGIGVIRMWADEGSRLSRFRMLFTSFVEPPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGVFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLRDKEISADLADLSEELDNYQKMRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQGHECPEQALEDRVMEEIPCEIYVRGREDSAQASISIDF
Protein: Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) (Q9P227)
Organism: Homo sapiens (Human)
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Interaction partners:
Sequence:
MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSFSSHHLMPCDTLARRRLARGRPDGEGAGRGGPRAPEPPGSASSSSQESLRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQPPRRSAASRLHQCL
Protein: Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2)) (O70469)
Organism: Mus musculus (Mouse)
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.
Interaction partners:
- Ras GTPase-activating protein 1
- Cell surface glycoprotein CD200 receptor 1
- Angiopoietin-1 receptor
- Tyrosine-protein kinase HCK
- SH2/SH3 adapter protein Nck1
- Growth factor receptor-bound protein 2
- Tyrosine-protein kinase CSK
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Sequence:
MVRMEEPAVKQGFLHLQQQQTFGKKWRRFAAVLYGESGCALARLELQDVPEKTRRGEATRKVVRLSDCLRVAEVGSEASSPRDTSAFILETKERLYLLAAPSAERSDWIQAICLLAFPGQRKGSPGLEEKSGSPCMEENELYSSSTTGLCKEYMVTIRPTEASERCRLRGSYTLRTGVSALELWGGPEPGTQLYDWPYRFLRRFGRDKATFSFEAGRRCLSGEGNFEFETRHGNEIFQALEKVIAVQKNATPSGPPSLPATGPMMPTVLPRPESPYSRPHDSLPSPSPGTLVPGMRPGAPEGEYAVPFDTVAHSLRKSFRGLLTGPPPHLPDPLYDSIQEDPGAPLPDHIYDEPEGVAALSLYDRTQRPSGETWREQATADGGPSSLQQDSSVPDWPQATEYDNVILKKGPK
Protein: Alpha-2,8-sialyltransferase 8F (EC 2.4.99.-) (Sialyltransferase 8F) (SIAT8-F) (Sialyltransferase St8Sia VI) (ST8SiaVI) (Q8K4T1)
Organism: Mus musculus (Mouse)
Function: Alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRSGGTLFALIGSLMLLLLLRMLWCPADAPARSRLLMEGSREDTSGTSAALKTLWSPTTPVPRTRNSTYLDEKTTQITEKCKDLQYSLNSLSNKTRRYSEDDYLQTITNIQRCPWNRQAEEYDNFRAKLASCCDAIQDFVVSQNNTPVGTNMSYEVESKKHIPIRENIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGAEIDKSDFVFRCNLPPITGSASKDVGSKTNLVTVNPSIITLKYQNLKEKKAQFLEDISTYGDAFLLLPAFSYRANTGISFKVYQTLKESKMRQKVLFFHPRYLRHLALFWRTKGVTAYRLSTGLMIASVAVELCENVKLYGFWPFSKTIEDTPLSHHYYDNMLPKHGFHQMPKEYSQMLQLHMRGILKLQFSKCETA
Protein: Endomucin, isoform CRA_a (cDNA, FLJ94060, Homo sapiens endomucin (EMCN), mRNA) (Q4W5J1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MELLQVTILFLLPSICSSNSTGVLEAANNSLVVTTTKPSITTPNTESLQKNVVTPTTGTTPKGTITNELLKMSLMSTATFLTSKDEGLKATTTDVRKNDSIISNVTVTSVTLPNAVSTLQSSKPKTETQSSIKTTEIPGSVLQPDASPSKTGTLTSIPVTIPENTSQSQVIGTEGGKNASTSATSRSYSSIILPVVIALIVITLSVFVLVGLYRMCWKADPGTPENGNDQPQSDKESVKLLTVKTISHESGEHSAQGKTKN
Protein: Alkyltransferase-like protein 1 (Q9UTN9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts. The DNA is bent, the damaged base is rotated out of the DNA duplex into a hydrophobic binding pocket (nucleotide flipping), with Arg-39 donating a hydrogen bond to the orphaned cytosine to stabilize the extrahelical DNA conformation. This structural change in DNA presents the lesion to the nucleotide excision repair (NER) pathway. The affinity for O(6)-alkylguanine adducts increases with the size of the alkyl group. Low affinity small O(6)-alkylguanines are directed to the global genome repair pathway of NER via rhp7-rhp16 and rhp41-rhp23, while strong binding to bulky O(6)-alkylguanines stalls the transcription machinery and diverts the damage to the transcription-coupled repair pathway of NER via rhp26.
Interaction partners:
- DNA repair protein rhp26
- DNA repair protein rhp7
- ATP-dependent helicase rhp16
- DNA repair protein rad14
Sequence:
MRMDEFYTKVYDAVCEIPYGKVSTYGEIARYVGMPSYARQVGQAMKHLHPETHVPWHRVINSRGTISKRDISAGEQRQKDRLEEEGVEIYQTSLGEYKLNLPEYMWKP
Protein: 6-phospho-beta-glucosidase AscB (EC 3.2.1.86) (P24240)
Organism: Escherichia coli (strain K12)
Function: Can hydrolyze salicin, cellobiose, and probably arbutin.
Interaction partners:
- PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component
- 6-phospho-beta-glucosidase
- PTS system N,N'-diacetylchitobiose-specific EIIB component
- PTS system N,N'-diacetylchitobiose-specific EIIA component
- Periplasmic beta-glucosidase
- PTS system N,N'-diacetylchitobiose-specific EIIC component
- HTH-type transcriptional regulator AscG
- PTS system beta-glucoside-specific EIIBCA component
- Glucose-6-phosphate isomerase
- PTS system glucose-specific EIIA component
Sequence:
MSVFPESFLWGGALAANQSEGAFREGDKGLTTVDMIPHGEHRMAVKLGLEKRFQLRDDEFYPSHEATDFYHRYKEDIALMAEMGFKVFRTSIAWSRLFPQGDEITPNQQGIAFYRSVFEECKKYGIEPLVTLCHFDVPMHLVTEYGSWRNRKLVEFFSRYARTCFEAFDGLVKYWLTFNEINIMLHSPFSGAGLVFEEGENQDQVKYQAAHHQLVASALATKIAHEVNPQNQVGCMLAGGNFYPYSCKPEDVWAALEKDRENLFFIDVQARGTYPAYSARVFREKGVTINKAPGDDEILKNTVDFVSFSYYASRCASAEMNANNSSAANVVKSLRNPYLQVSDWGWGIDPLGLRITMNMMYDRYQKPLFLVENGLGAKDEFAANGEINDDYRISYLREHIRAMGEAIADGIPLMGYTTWGCIDLVSASTGEMSKRYGFVFVDRDDAGNGTLTRTRKKSFWWYKKVIASNGEDLE
Protein: Vesicle-fusing ATPase (EC 3.6.4.6) (B5X134)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU367045}.
Interaction partners:
Sequence:
MAARTMQAARCPTDDLSLTNCAVVSEKDLQSGQHVTVKTTPTHKFVFTTKTHHAIVPGTIAFSLPQRKWAGLSIGQEVEVANYNFDKSQQCIGAMTIEIDFLQKKSTDTSPYDSDKMASEFIQQFNNQAFSVTQQMVFSFCDKLFGLVIKDIEAMDASILKGEPASGKKQKIDIGLLVGNSQVVFEKAESSSLTLVGKAKTKEQRQTIINPDWNFERMGIGGLDKEFSDIFRRAFASRVFPPDIVEQMGCKHVKGILLFGPPGCGKTLMARQIGKMLNSREPKIVNGPEILNKFVGESEANIRKLFADAEEEQKRLGANSGLHIIIFDELDAICKQRGTGQGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDDALMRPGRFEVKMEIGLPDEKGRVQILNIHTNKMRDFGLLAPDVDVKELAAGTKNYSGAELEGLVRAAQSTAMNRHIKATATVEVDTERAEKLQVTRSDFMGSLNNDIKPAFGSNQEDYASYIMNGIIKWGDPVTCVLDDGELLVQQTKNSDRTPLVAVLLEGPPHSGKTALAAQISESSEFPFIKICSPDKMIGFSENSKCLAIKKIFEDAYKSQLSCVVVDDIERLLDYVPIGPRFSNMVLQALLVLLKKTPPKGRKLLIIGTTSRKEVLQEMEMLDAFSTTIHVPNISTGEHLVEALELLGSFTDAERVTIGQHVKGKRVWIGIKKLLMLIEMSLQMDVEYRVTKFLQLLRDEGAERTDRNDRSYKLD
Protein: Interleukin (O73883)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Interleukin-4
- Ig-like domain-containing protein.
- Ig-like domain-containing protein.
- Uncharacterized protein.
- Interleukin-10
- Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
- Interleukin-6
- Interferon gamma
- Interleukin-5
- Interleukin-2 receptor subunit beta
Sequence:
MMCKVLIFGCISVAMLMTTAYGASLSSAKRKPLQTLIKDLEILENIKNKIHLELYTPTETQECTQQTLQCYLGEVVTLKKETEDDTEIKEEFVTAIQNIEKNLKSLTGLNHTGSECKICEANNKKKFPDFLHELTNFVRYLQK