wanglab/gogpt-training-data huggingface dataset:
Protein: NADH-quinone oxidoreductase subunit A 2 (EC 7.1.1.-) (NADH dehydrogenase I subunit A 2) (NDH-1 subunit A 2) (NUO1 2) (Q9I0K1)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01394}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01394}.
Interaction partners:
- NADH-quinone oxidoreductase subunit E
- NADH-quinone oxidoreductase subunit M
- NADH-quinone oxidoreductase subunit N
- NADH-quinone oxidoreductase subunit K
- NADH-quinone oxidoreductase subunit H
- NADH-quinone oxidoreductase subunit C/D
- NADH-quinone oxidoreductase subunit B
- NADH-quinone oxidoreductase subunit J
- NADH-quinone oxidoreductase subunit F
- NADH-quinone oxidoreductase subunit I
Sequence:
MPNPAELAAHHWGFAAFLLGVVGLLAFMLGVSSLLGSKAFGRSKNEPFESGIVPTGGARLRLSAKFYLVAMLFVIFDVEALFLFAWSVSVRESGWAGLIEATIFIAILLAGLVYLWRIGALDWAPESRRKRQAKLKQ
Protein: Cytoplasmic protein (B2RZ33)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR037874}. Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874}.
Interaction partners:
Sequence:
MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDTASPADDSFVDPGERLYDLNMPAFVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQIGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKHLS
Protein: Transmembrane protein (P71599)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv0030
- Uncharacterized protein Rv0028
Sequence:
MAIFGRWSARQRLRRATRESLTIPTFSSSLDCTTRVIGGLWPAELSSNTAETATLAEHLKADLHRIVGSANDELMVIWRAGMADSTRRAEEDRVIDRARASAMRRVESAMRELRQITGRVPVEIPRMRGAGGSDLDTTRLMPAVTVVQPADQACTDWPVAAAEDDEARLQRLLAFVARQEPRLNWAVGVHADGTTVLVTDVAHGWIPPGIALPEGVRLLAPARRAGRAPELVGITTCCKTYTPGDSLRRAVDSTAPTSSVQPRALPAIAGLSVELGIATQRHDGLPKIVHAMATAAGNGAAAEEVDLLRVHVDTALHHVLAQYPRVDPALLLNCMLLAATERSVTGDPIAANYHFAWFRELDSRR
Protein: Sorting nexin-4 (O95219)
Organism: Homo sapiens (Human)
Function: Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:17994011, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:33468622}; Peripheral membrane protein {ECO:0000269|PubMed:17994011}; Cytoplasmic side {ECO:0000269|PubMed:17994011}. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC). {ECO:0000269|PubMed:17994011}.
Interaction partners:
- Sorting nexin-7
- Sorting nexin-1
- Sorting nexin-30
- Sorting nexin-6
- Syntaxin-16
- Vesicle-associated membrane protein 2
- Syntaxin-12
- Cytoplasmic dynein 1 light intermediate chain 1
- Vesicle-associated membrane protein 7
- Vesicle-associated membrane protein 8
Sequence:
MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM
Protein: E3 ubiquitin-protein ligase Arkadia isoform X3 (Ring finger protein 111) (F1QWE1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
Interaction partners:
Sequence:
MKSEISADARQKQEPLKGPLANPEPMETAKSFPAEMEVIGKAGSDFTSPLCAETRHRPSRDAGGRRDCERGLSGRKKRKSQQPGPSYCSLKEAPMSEATLTPPRHRPMLLETRSEDERNPESSLSDCASSPSSSLRFGDSDTLSSDEDGMPMTVRQQLKAHGAASTGSTGSSTGTAVGIRPLLARTRASRSHKWARLEPDSNHVKRPCLGSRRPLHRKRFVKGGAGGVTQRTPKQKERLLLQRKKREVIARKKYALLHSTSSSSEEMTSDDSSPSSTEAEHELYVDVNSSSSQASTAAVASGVLDEDVVVIEATPAPAVPASEEINVTSTDSEVEIVTVGDAFRPRSVGGHGRMHWGPSCSQSRAQEGRGRHRLSTVIQPLRQSAGEVVDLTVDEDDLSVVPTTSDSTHPQPVSSSSSSSSRNACTSASPQEGPGPSSSCSAAAPDSTLAAQSHGGVPRSGTTNTTATEDESRRSLLGENGGVAMPRLPSCCPQHSPCSGPSSGHLSMGHTHSGCMQSGATQQSGPPQPGSQHSHTHSHHFHHHHHTAPVPSSLAYQESSCPLERPTAMPAPCGGVSNQYHDQQTLPVDLSSSAVRSSGSSSTGFHGTSAFDPCCPGSASRPPVYVSQAAPGPSQQTVADSFSPTIVAQPQPQPPQLSSCRHYMHPTYGSLSRPLHHQSSSSCPHSHSNAPPPQQPPPQGDYVIPHPVLPFHTPLPTHAPGHTVPTAPPPSLPSHHLPGSSAPLPQHLPPEHQALQHHLPVLGPNSVQRLHHHDLLQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSLPRQSDQRTTWELGIEAGVTVAPYPSGHLHPHLPHYHPPPRLHHFPIQLMHTGSMPEVTYPHIRYISSRMTFGRTYEDLLHLEERLGTVNRGASQGTIERCTYPHKYKKRKLHGKQEEEEGAEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQLCVDQWLLTNKKCPICRVDIEAQLSSES
Protein: TLC domain-containing 3Ba (X1WH51)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLSILAAGSIFFPGLFLLSKRFLKHAPGLKWSEKDAVIVSSRLVSSVQAIMASSAGYIIACSCKDIIEDQHWLTTSYILFAVPYFVYDIYAMFLCYWYKLQVKDHEEESETKPMRSAIRGYLHREFLMVLHHVVMVTVCFPVSVFWRQGKGDYFQGVMFLAELSTPSVCLGKILIQIRVHPLLHGAAVCSLAV
Protein: Transcription factor bHLH60 (Basic helix-loop-helix protein 60) (AtbHLH60) (bHLH 60) (Transcription factor EN 91) (bHLH transcription factor bHLH060) (Q3EAI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MDLTGGFGARSGGVGPCREPIGLESLHLGDEFRQLVTTLPPENPGGSFTALLELPPTQAVELLHFTDSSSSQQAAVTGIGGEIPPPLHSFGGTLAFPSNSVLMERAARFSVIATEQQNGNISGETPTSSVPSNSSANLDRVKTEPAETDSSQRLISDSAIENQIPCPNQNNRNGKRKDFEKKGKSSTKKNKSSEENEKLPYVHVRARRGQATDSHSLAERARREKINARMKLLQELVPGCDKGTDFGGKIKIKVCFGVHLLMISGKKVAIFLWKVSCEDLIDCSFSPPRIQGTALVLDEIINHVQSLQRQVEMLSMRLAAVNPRIDFNLDTILASENGSLMDGSFNAAPMQLAWPQQAIETEQSFHHRQLQQPPTQQWPFDGLNQPVWGREEDQAHGNDNSNLMAVSENVMVASANLHPNQVKMEL
Protein: TFIIH basal transcription factor subunit (Q4GZB0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- TFIIH basal transcription factor subunit
- TFIIH basal transcription factor subunit
- TFIIH basal transcription factor subunit
- TFIIH basal transcription factor subunit
Sequence:
MSQLSELLNTSQLTKYYALIQFLSSHTNTEYTLAQLDYLLPRGASLQRFPASWIEFMEEGLCNNQNVELYRRPVAGGEAAGENISSLVQEEREEIVLICRRPVINDLKDLARLLQSPATVPDVEGCVALHTDQITLNENLLRASQTQGLLYYFPDNYTKSREHRSAKSRRSSSQSEIVSNLMRNEDIEGLLNEESKDGKLDLPAGVTAQFMLYNRRGVPVRGRNSFPMRYNVGDRAMVIVERSVPPDADHVPAKPPLVTTTLGRPVGMSSVGGSDGSTPVEIRVKVSANSVGSQRTCISIKAQVKGRVVLSLFVDSRETIIPLEVLDESVGMPGVIVGREQQPLLPVPDDIRINDPAIWGSGNGDEQAGRGGVSGIDRDSGSCGNSALSWWLNPSPAILEVRDLTLPDSETFAAASRAVWNVHRADESAMKAVRKALKDQRNSETTRKKRNKRSRPRDLRNSHMIHYGFDASIPFGTQRSFPKDA
Protein: Engulfment and cell motility protein 3 (Q96BJ8)
Organism: Homo sapiens (Human)
Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Dedicator of cytokinesis protein 1
- WD repeat-containing protein 35
- Engulfment and cell motility protein 1
- Engulfment and cell motility protein 2
- Adapter molecule crk
- Rho-related GTP-binding protein RhoG
- Dedicator of cytokinesis protein 3
- PTB domain-containing engulfment adapter protein 1
- Dedicator of cytokinesis protein 4
- Dedicator of cytokinesis protein 5
Sequence:
MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADGHRRYITENNRAEIKNGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREVISRNGLQILGTIIEDGDDLGEVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVPPLALGLLESVTLSSPALGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRSLCAREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEPCSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFRKISSRRRQDKLWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMRALLTGKDCPHVREKGSGKQNKDLYELAFSISYDRGEEEAYLNFIAPSKREFYLWTDGLSALLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPPPVPPPPTNFNFCYDCSIAEP
Protein: Raftlin (Raft-linking protein) (Q6A0D4)
Organism: Mus musculus (Mouse)
Function: Involved in protein trafficking via association with clathrin and AP2 complex (By similarity). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion. May regulate B-cell antigen receptor-mediated signaling (By similarity). May play a pivotal role in the formation and/or maintenance of lipid rafts (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19414744}; Lipid-anchor {ECO:0000250|UniProtKB:Q14699}. Cytoplasm {ECO:0000250|UniProtKB:Q14699}. Membrane raft {ECO:0000250|UniProtKB:Q14699}. Endosome {ECO:0000250|UniProtKB:Q14699}. Early endosome {ECO:0000250|UniProtKB:Q14699}. Note=Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3. Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195). {ECO:0000250|UniProtKB:Q14699}.
Interaction partners:
Sequence:
MGCSLNKLEKREEKRPGNIYSTLKRPQVETKVDVTYEYCFLEFTTLTAAELPRSSATRLASLRDLPDQLLELYQQGFSLAALHPFVQPTRRQEKILLEHIFRAILVKKTNRSQKAELHDEGYTLELDYCSSLEHLADQKLIPEFIKKVQEAASQGLKFVSVVPQYQPSVSSAGSRRLKPVANSVEDARDVKCTLGDRSSLENDTPKAAETDAATAGVNRRPETKPGSTGDVPSAQQPGIPSPSAENEAGEFPLRGLQPALDRSEGDPSNGPEELPSRKMEIFAFFNRPKSQQKCRQYYPVTIPLQVSKNGQTVSSLDASWLEHMSDHFRKGGVLVNAVFQLGMANDSFYGLTDGVFIFEAVSTEDNRTTQGYDAIVVEQWTVLEGTEVQTDYMPLLNSLAAYGWQLTCVLPTPILKTTREGNVSTKQIVFLQRPCLPQKTKKRESKFQWRFSRNEIHGRQTRKSKGKLSASNKQQAEENEKNLEDQFSKAGDVGNCVLGAPQWGRASEVREQRQGSAAVQNGPAGHNRDSVALRHSNPRAEAELAAGPTPTEAN
Protein: Max-binding protein MNT (Myc antagonist MNT) (Protein ROX) (O08789)
Organism: Mus musculus (Mouse)
Function: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Subcellular location: Nucleus.
Interaction partners:
- Protein max
- Max-like protein X
Sequence:
MSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREREQEQKRASNLARLAHALPVEEPRIEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQSLPPPPPLPPAAQPLPLAPRQPALVSTPGLSIKEPVTLPTRPQVPTPAPLLPDAKTTVAPTGSPKPLQPLPAPILTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEAKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNVDEEMEGDRAGLGPPKLNHRPQPELLKSALPTPSTAPAPLPTHPHPHPHPVALSPAHLPVQQQQPPQQKTPLPAPPPPPATPTQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA
Protein: HP1 and insulator partner protein 1, isoform C (M9PG20)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEQVSDSAVTTLESTQAEEPPPGVEKVETLELKTAALETLSESAGPTDLENELANLNGSEEGPGLDELSTLEREIAKLHNIRPPDAASEVKDSDTPIALADNGGLEPRQAPDEAKCRTPIIEEGNAASGNGQSSESPLEEVDLIALLKGTDTSHDQPTGEEKCTLEKALSELDGVGEDGDVGVTIEGEGQFEIMEIDDDEGESSSRKASPKVPASKPIKSNSLPSISKHKLSPEQARAVALEQMAGLKPKSRRKEPPAPPSVVAPIDIVSSLNDDWDDYDSEEDKSASALVTEVITLPSAHVVTKKPPLPVKKLSSPVKHSPNSAILLNNKISGVKVMLKTVSQKQLAASTGAAAEKTKPTVVVSPPKETEEHTTGFKRMRVIKRKIIWDPDVPETKKSFAQYASTKAACPAPTTPKTTVKSISPTTTTKKEVAPKKRSATPTARSTKAGTPVGGTERGPSPVKRRAQTPNTGLANGGTQKKKKVSEIDRLMGDEGAANMIHAVEHEQRELSGGEVSNKPLMRKRAMTITGRNQAARVAVEPTPPKKESAQSAAKRTPADSVFTKATANTSARKPRASDSWDYVYKQRASEESMIMRRRSNSSYSSNASVSRNSLDNRPGAANLSDDAGEGSDPSFKFVKPVSKSSQRGGEDTSSHTLANDMKANNGSELVCLHKVNKVAHLVIHTERGNFGHTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRKDSASQLAVALKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEHSRLFLMGERLFATELLESNSFVDKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGEQWVTADCLANFKRYLNDVDF
Protein: Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16) (Q6KF10)
Organism: Homo sapiens (Human)
Function: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:23307924}.
Interaction partners:
- Bone morphogenetic protein receptor type-1B
- Bone morphogenetic protein receptor type-1A
- Noggin
- Bone morphogenetic protein receptor type-2
- Activin receptor type-2A
- Activin receptor type-2B
- Chordin
- Neuroblastoma suppressor of tumorigenicity 1
- Glycodelin
- Anti-Muellerian hormone type-2 receptor
Sequence:
MDTPRVLLSAVFLISFLWDLPGFQQASISSSSSSAELGSTKGMRSRKEGKMQRAPRDSDAGREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCLSPLLLDARTLDPQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR
Protein: threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) (Q5XIZ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MADESVTDQLKELKMEEKKNTKDGGKKKNKNAAGDAGGKTELSPPPQYIDERLSIYNKLKEEHDALLAEKAAKESKPIKITLPDGKVVDGESWKTTPYQVACGISQGLADNTVISKANNGVWDLDRPLEEDCSLVFLKFDDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLDNEGVSSNDFPCLENLCKKIIKEKQPFERLEVKKETLLEMFKYNKFKCRILNEKVTTPTTTVYRCGPLIDLCRGPHVRHTGKIKAMKIHKNSSTYWEGKADMESLQRIYGISFPDPKMLKEIFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCSMDQIESEIKGCLDFLRTVYDVFGFTFKLNLSTRPEKFLGEPEVWDQAEKQLENSLNDFGEKWVLNPGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTFVSHDGDDKKRPVIIHRAILGSVERMIAILTENYGGKWPLWLSPRQVMVVPIGPTCDEYAQRVQKEFHKVGLMTDVDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKSSDTVNVRTRDNKVHGERSLTDCMERLKQLKASRTRNAEEEF
Protein: Anti-Mullerian hormone (Muellerian-inhibiting factor isoform X1) (A8E7B8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Aromatase
- Doublesex- and mab-3-related transcription factor 1
- Forkhead box protein L2
- Gonadal soma derived factor variant 1
- receptor protein serine/threonine kinase
- receptor protein serine/threonine kinase
- Receptor protein serine/threonine kinase
- Chordin
- Neuroblastoma suppressor of tumorigenicity 1
- Bone morphogenetic protein 15.
Sequence:
MLFQARFGLMLMMTVAIGSYCATVRHEEQDNNPKVNPLSELNGDQLEVRDLACVHRQQPTDQYATEDTPFNKEQKTLNEFLSALKSAGELGKMDFVGTCSPETQSSQVSHLVQSVLQKQSGLKGVHATEDIWDADNEGGITLTLTFPKHSLPAGPASVMLLFSVNPVKGDSLRVQFNSQSIHPNTQTVCISESTRFLIVTGGWSHGHIHLKLKTMVETSMDDNRPKLSVSELKEVLMRKVDSSSTMIKPVLLFLSDLEEPRLKHHRIPQDERLPSRTYLFLCELQKFLRDILPQSKSTTPQDDPSAVSLDTLHSLPPLRLGVSSTESLLSGLVNSSTPTVFVFPQRQQGLQTHRVEVTLDSPLLSVLRMRLDEAMAQVKQQEAGRKMIDRLQKLTELSALSPDGEDSEAATKDHKEAQYRSVLLLKALQMVLSNWESERAQRAARADEDGPSASNQCHLQSLSVSLRKFFLEPSRANINNCEGTCGFPLNNANNHAVLLNSHIQSGQPVNRSLCCVPVEYDDLCVIELESETTNISYKTNVVATKCECR
Protein: Prodigiosin synthesizing transferase PigC (EC 6.4.-.-) (Prodigiosin synthetase PigC) (Q5W252)
Organism: Serratia marcescens
Function: Involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the transfer of 2-methyl-3-n-amyl-pyrrole (MAP) to 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC) to yield prodigiosin. It is able to use substrates with a variety of monocyclic rings in place of the pyrrolic ring A of its natural substrate.
Interaction partners:
Sequence:
MNPTLVVELSGDKTLEPHRLGGKAHSLNHLIHAGLPVPPAFCITAQAYRQFIEFAVPGALLDTGAPGNVRDMILSAAIPAPLDLAIRHACKQLGDGASLAVRSSALEEDGLTHSFAGQYDTYLHVRGDDEVVRKVQSCWASLWAERAAQYSRTSAAQSDIAVVLQIMVDADAAGVMFTQDPLTGDANHIVIDSCWGLGEGVVSGQVTTDSFILDKASGEIRERQIRHKPHYCQRDPQGRVTLLQTPEARRDAPSLTPEQLQQLARLARQTRMIYGAELDIEWAVKDDRVWLLQARPITTQAKPVQMLYANPWESDPTIKERAFFSRMDTGEIVTGLMTPLGLSFCQFYQKHIHGPAIKTMGLADIGDWQIYMGYLQGYVYLNISGSAYMLRQCPPTRDEMKFTTRYATADIDFSGYKNPYGPGVQGWAYLKSAWHWLKQQRHNLRSAGATVDAMIALRQRETRRFLALDLTTMTHQELERELSRIDGYFLDSCAAYMPFFLQSFALYDALALTCERYLKGRGNGLQNRIKASMNNLRTIEVTLGILSLVETVNRQPALKALFERHSAQELVTVLPTDPESRAFWQSDFSAFLFEFGARGRQEFELSLPRWNDDPSYLLQVMKMYLQHPVDLHTKLRETERLRHEDSAALLKAMPWFGRMKLKFITKLYGVMAERREATRPTFVTETWFYRRIMLEVLRRLEAQGLVKSADLPYVDFERFRAFMAGEQSAQEAFAADLIERNRHQHLLNLHAEEPPMAIVGGYQPRMKAPTAENAAGMLSGLAASPGKVVAKARVITDLLAQAGELQPNEILVARFTDASWTPLFALAAGIVTDIGSALSHSCIVAREFGIPAAVNLKNATQLINSGDTLILDGDSGTVIIQRGERADG
Protein: BTB domain-containing protein (Q384L1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRERKPIRKMKRSRVSDQIIRVEEPDAEEGEASPAKATPVPHFSDRRICINVGGEYITTLASTLCSEPSKFSEWVENNFQGLPRDSMGNPFIDRDPENFRQIISYLRGYELPTATEKIVFLAEDAEYYHIDRLLALINPPAEWRFVSGPGVSSSRKEFSTENILATCGNEPLPQVGKSVFLLRIDKCELVSIGLVGTESPDHDEPLERQTNAIAYRSTGELIRSLNSSSTFFSGNGYKGRDTVMVQVLFKPEGAAQIEFFCNDVKTHETEWLSPVPPLRFAVSLHGVSAVVIERCVAGVKDEDM
Protein: Netrin-4 (Beta-netrin) (Q9JI33)
Organism: Mus musculus (Mouse)
Function: May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
Interaction partners:
- Netrin receptor UNC5A
- Neogenin
- Netrin receptor DCC
- Netrin receptor UNC5B
- Laminin subunit gamma-1
- Netrin receptor UNC5C
Sequence:
MGSCARLLLLWGCSAVAAGLNGVAGANSRCEKACNPRMGNLALGRKLRADTMCGQNATELFCFYSENADLTCRQPKCDKCNAAHSHLAHPPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIMVFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSRYSNPFPCTGGEVIFRALSPPYDIENPYSAKVQEQLKITNLRVRLLKRQSCPCQINDLNAKPHHFMHYAVYDFIVKGSCFCNGHADQCLPVEGFRPIKAPGAFHVVHGRCMCKHNTAGSHCQHCAPLYNDRPWEAADGRTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCNNCQHNTEGQHCQRCKPGFYRDLRRPFSAPDACKACSCHPVGSAILPFSSVTFCDPSNGDCPCKPGVAGPHCDRCMVGYWGFGDYGCRPCDCAGSCDPLTGDCISSNADVDWYHEVPAFHSMHNKSEPSWEWEDEQGFSALRHSGKCECKEQVLGNPKAFCGMKYSYVLKIKILSAHDKGSHAEVNVKIKKVLKSTKLKILRGKRTLYPESWTNRGCTCPILNPGLEYLVAGHEDVRTGKLIVNMKSFVQHWKPALGRRVMHILKRDCV
Protein: Enoyl-[acyl-carrier-protein] reductase [NADH] (ENR) (EC 1.3.1.9) (Trans-2-enoyl-CoA reductase) (TER) (EC 1.3.1.44) (Q9HZP8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It can use both crotonyl-CoA and trans-2-decenoyl-ACP. It is able to convert trans-2-enoyl-ACP of different length (C2 to C16) to the corresponding acyl-ACP.
Interaction partners:
- Enoyl-[acyl-carrier-protein] reductase FabI
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
- 3-oxoacyl-[acyl-carrier-protein] synthase 1
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Probable enoyl-CoA hydratase/isomerase
- Probable enoyl CoA-hydratase/isomerase
- Probable enoyl-CoA hydratase/isomerase
- Probable enoyl-CoA hydratase/isomerase
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
Sequence:
MIIKPRVRGFICVTTHPAGCEANVKQQIDYVEAKGPVVNGPKKVLVIGSSTGYGLAARITAAFGSGADTLGVFFERPGSESKPGTAGWYNSAAFEKFAHEKGLYARSINGDAFSDEVKRLTIETIKRDLGKVDLVVYSLAAPRRTHPKSGEVFSSTLKPIGKSVSFRGLDTDKEVIKDVVLEAASDQEVADTVAVMGGEDWQMWIDALLEADVLADGAKTTAFTYLGEKITHDIYWNGSIGAAKKDLDQKVLGIRDKLAPLGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKEQGTHEGCIEQVDGLYRESLYGAEPRLDEEGRLRADYKELQPEVQSRVEELWDKVTNENLYELTDFAGYKSEFLNLFGFEVAGVDYEQDVNPDVQIANLIQA
Protein: Signal transducer and activator of transcription 5B (P42232)
Organism: Mus musculus (Mouse)
Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20639532}. Nucleus {ECO:0000269|PubMed:20639532}. Note=Translocated into the nucleus in response to phosphorylation.
Interaction partners:
- Tyrosine-protein kinase JAK2
- Signal transducer and activator of transcription
- Tyrosine-protein kinase JAK3
- Non-receptor tyrosine-protein kinase TYK2
- Epidermal growth factor receptor
- Signal transducer and activator of transcription 3
- Cytokine-inducible SH2-containing protein
- Receptor tyrosine-protein kinase erbB-4
- Interleukin-2 receptor subunit alpha
- Tyrosine-protein kinase JAK1
Sequence:
MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWDSIDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQSTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFDSQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCEPATAKAADGYVKPQIKQVVPEFANASTDAGSGATYMDQAPSPVVCPQAHYNMYPPNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS