wanglab/gogpt-training-data huggingface dataset:
Protein: Fatty acyl-CoA reductase 1 (Far1) (EC 1.2.1.84) (Q922J9)
Organism: Mus musculus (Mouse)
Function: Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (By similarity). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:15220348}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8WVX9}.
Interaction partners:
- Dihydroxyacetone phosphate acyltransferase
- Alkyldihydroxyacetonephosphate synthase, peroxisomal
Sequence:
MVSIPEYYEGKNILLTGATGFLGKVLLEKLLRSCPRVNSVYVLVRQKAGQTPQERVEEILSSKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEIIIDSTNVIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTMRASNNALADLVPVDVVVNTSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVEYHVISTFKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTITRLHKAMVFLEYFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCMGTKKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSYFRASSTMRY
Protein: Putative cyclin-A3-1 (G2/mitotic-specific cyclin-A3-1) (CycA3;1) (Q9FMH5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cyclin-dependent kinase A-1
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinase B2-2
- Cyclin-dependent kinases regulatory subunit 2
- Cell division control protein 6 homolog
- Wee1-like protein kinase
- Transcription factor E2FC
- Cyclin-dependent kinases regulatory subunit 1
Sequence:
MADEKENCVRMTRAATKRKASMEAAIDKERINKKRVVLGELPNLSNIKKSRKATTKQKKKSVSIPTIETLNSDIDTRSDDPQMCGPYVTSIFEYLRQLEVKSRPLVDYIEKIQKDVTSNMRGVLVDWLVEVAEEYKLLSDTLYLAVSYIDRFLSLKTVNKQRLQLLGVTSMLIASKYEEITPPNVDDFCYITDNTYTKQEIVKMEADILLALQFELGNPTSNTFLRRFTRVAQEDFEMSHLQMEFLCSYLSELSMLDYQSVKFLPSTVAASAVFLARFIIRPKQHPWNVMLEEYTRYKAGDLKECVAMIHDLYLSRKCGALEAIREKYKQHKFKCVATMPVSPELPLTVFEDVNI
Protein: Glutathione synthetase (GSH-S) (EC 6.3.2.3) (Q7XB40)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
MSAAMPPAMDPAAAGEMAREAAAWCSLHGLVVGDRADQRSATVPGVGLVHAPFSLLPAHFPESFWRQACELAPVFNELVDRVSMDGNFLQNALSKTRQVDDFTSRLLEIHRKMMEINKEENIRLGLHRSDYMLDSETSSLLQIELNTISASFPGLGSLVSDLHRSLIKQYGTSLSLEHKRVPANAASTQFSEALAQAWSEFNIDSAVIMMIVQPEERNMYDQYWLSKHLQDSHGITTIRKTLSQVEAEGQVLPDGTLLVGGQKVAVVYFRAGYAPNDYPSEAEWSARLMMEQSSAVKCPSISYHLVGTKKIQQELAKPNVLERFLKSEEIDKVRKCFAGLWSLDDEYIIKTAVEKPELFVLKPQREGGGNNIYGLDLRETLVRLQKEGGDALAAYILMQRIFPKASPAYLVRGGVCHEGLAISELGIYGAYLRNKDKVVINEQCGYLMRTKVSSSDEGGVAAGFAVLDSLYLTGK
Protein: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (Q8IJH3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- orotate phosphoribosyltransferase
- Dihydroorotate dehydrogenase
- UMP-CMP kinase, putative
- NADH-cytochrome b5 reductase, putative
- indole-3-glycerol-phosphate synthase
- carbamoyl-phosphate synthase
- aspartate carbamoyltransferase
- GMP synthase
Sequence:
MGFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNNIKKNLKEKYINNVSIKKDILLKAPDNIIREEKSEEFFYFFNHFCFYIINETNKYALTFKMNFAFYIPYGSVGIDVLKNVFDYLYELNIPTILDMKINDIGNTVKNYRKFIFEYLKSDSCTVNIYMGTNMLKDICYDEEKNKYYSAFVLVKTTNPDSAIFQKNLSLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFVVGANSYDEMNYIRTYFPNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIGRAITKNPYPQKAAQMYYDQINAILKQNMES
Protein: Glucose-dependent insulinotropic receptor (G-protein coupled receptor 119) (Q8TDV5)
Organism: Homo sapiens (Human)
Function: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Pro-glucagon
- Gastric inhibitory polypeptide
- Pro-opiomelanocortin
- G-protein coupled receptor 55
- VIP peptides
- Pituitary adenylate cyclase-activating polypeptide
- Follitropin subunit beta
- Natriuretic peptides A
- Thyrotropin subunit beta
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
Protein: Polysialic acid O-acetyltransferase (EC 2.3.1.-) (Polysialyltransferase) (PST) (Q93S40)
Organism: Neisseria meningitidis
Function: Catalyzes the O-acetylation of capsular polymeric sialic acid consisting of polymers of (2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl residues. Shows high substrate specificity toward polymers of sialic acid that contains a large number of residues.
Interaction partners:
Sequence:
MGTHMYSEQGINNTINISTTSLTNATQLTVIGNNNSVYIGNNCKIVSSNIRLKGNNITLFIADDVENMGLVCSLHSDCSLQIQAKTTMGNGEITIAEKGKISIGKDCMLAHGYEIRNTDMHPIYSLENGERINHGKDVIIGNHVWLGRNVTILKGVCIPNNVVVGSHTVLYKSFKEPNCVIAGSPAKIVKENIVWGRKMYHSTMYDDPTLNEFYK
Protein: Rho GTPase activating protein at 71E, isoform D (B7Z058)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Rho GTPase-activating protein 92B
- Ras-like GTP-binding protein Rho1
- Rho GTPase-activating protein 39
- FI17823p1
- Rho guanine nucleotide exchange factor 2, isoform D
- Rho GTPase activating protein at 16F, isoform E
Sequence:
MSSWAERVHRRAADLGNVVTSCGHPATAPAYPYRLEKVKFGVPLEEVCKHNNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGRLVNVDNYSVFTIASVLKKFLRKIPNGIFGRSGEMELFAINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNAAHASTGMTSEALGVSVAPSFFQSCVSDGKTARMEDVLKFKVSTKIMQNIIDKFATHDIFGRDNYEYYARVTGRILKVQDEWICSFQYPPPPRGKLAQQKYALQHSLEAEKTWLQCQCERWGLLAQEESRSTPALLTSSSSALENSVLSLGVSPEHSFIESCARLSVSLEGPGIYAMTSSPLPAKRNGNGNGNATDYDYDDYADDDEDNDELDGVHDFGAELEISSIAPPQGSRGIYRHKQRAQQQPHHYQQQQQQQQVPPQHQRDYDEDDDDDEDEMTFIKRRYRQNKKKPAPPSSSHHQRRLRTGTKSLDGGGERRTGSGAAGGSGGGASGSAVGNPTPPKLKQRTCSRCNRGIRHSSSCSSNSAGATGSNSGGGGNGGSGAGNGGGAEGGMTMEELRAVNRYAESTKSLSYLPQVHERQTARMRTRSEWFLGPRDAVVTLQLPADTCSNCCLAAAAGYLGGGSTRDMRQAQTEGERNQAALLYHFYRRQQQQQQQQQEQHYDDMMDTEDSYGQQKEQQHQQQQQQEQQQQHIHSKGLLRPPPMQHQHQQQQQQRRLLLDVNSGSYNAGLTTLTTNNTHFGDDLANYLHEPLSNTCYYSSSQCLNRLPPVVVVREDQQLTEVTDSDGDGDSLDGGVLHTLQAHELQHHVEPRQAAMLLLRHSTPQQQHRSSMASSLYQSFDVTSADLSHGNDHNRSGHNNSNNNHHHNNNFATVIFNVLDFFWQHPFE
Protein: Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) (P17444)
Organism: Escherichia coli (strain K12)
Function: Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:3512525}; Peripheral membrane protein {ECO:0000269|PubMed:3512525}.
Interaction partners:
- Betaine aldehyde dehydrogenase
- HTH-type transcriptional regulator BetI
- High-affinity choline transport protein
- Putative ankyrin repeat protein YahD
- Phospholipase A1
- Bifunctional protein Aas--phospholipid O-acyltransferase); Acyl-[acyl-carrier-protein] synthetase
- Phosphatidylserine decarboxylase proenzyme
- Glycine betaine/proline betaine transport system permease protein ProW
Sequence:
MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDMGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEGDSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKMGYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALPRSTAGYFVANGMPVRAKK
Protein: Zinc finger protein 639 (J3KR59)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNEYPKKRKRKTLHPSRYSDSSGISRIADGFNGIFSDHCYSVCSMRQPDLKYFDNKDDDSDTETSNDLPKFADGIKARNRNQNYLVPSPVLRILDHTAFSTEKSADIVICDEECDSPESVNQQTQEESPIEVHTAEDVPIAVEVHAISEDYDIETENNSSESLQDQTDEEPPAKLCKILDKSQALNVTAQQKWPLLRANSSGLYKCELCEFNSKYF
Protein: RNA binding protein, mRNA processing factor (E5RJ31)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAFTYPASLHAQVIDTHRPGLHSLHHQSFQTWFPRAHHTTNTYPANRSTLKRLMIPSKSS
Protein: Antitoxin HigA-2 (Q9KMA5)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system that counteracts the effect of the HigB-2 toxin. Binds to its own promoter and regulates transcription of the higB-2/higA-2 operon.
Interaction partners:
- Toxin HigB-2
- Antitoxin HigA-1
- Toxin HigB-1
Sequence:
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVPNGQAVTLLKLVQRHPETLSHIAEL
Protein: Skp1-related protein (G5EE98)
Organism: Caenorhabditis elegans
Interaction partners:
- Cullin-1
- Cullin-6
- F-box/WD repeat-containing protein lin-23
- RING-box protein 1
Sequence:
MTTPRSAPLYKLKSEDGQIFNVERGPMKFCAFINQKFIDHGVNDRNCERADPILVPFHSSIVQAVIEWLYHYQDNPLARRDSKIRYHDFSEWDKQFFNVESGVLFALLNASHALGVEDLMNMGCAAAAELIRGKSTEEIRKIYGIRSDEEQMEEALANGGEGTSAMTFTTDSD
Protein: Cop9 signalosome complex subunit 11 (Proteasome-COP9 signalosome-eIF3 domain protein 8) (P40512)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response. PCI8 may also be involved in transcriptional and translational control.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:14562095}. Nucleus {ECO:0000305|PubMed:14562095}.
Interaction partners:
- Cop9 signalosome-interactor 1
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 10
- COP9 signalosome complex subunit 9
- 26S proteasome regulatory subunit RPN5
- Cop9 signalosome complex subunit 12
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit A
Sequence:
MFHGAKGPLLIERIGHLLSINYGEKEERKRWAMQGISYLQEVQCTSTPYLEILVEESGLRPVSLLNSQLVGKPHFSLLGGFDENIARDIISHNFQNAIFQMESEEVPLTKRYQHLEKITQISLLCKNFKGIEEIEYNVKNIIQGRKNFDMLNSMEKDRISHEVVQDDSFSLLRIQMLLCVSYFLQERYFDCCTKFFTMMTSEPLTLKVLSEHLDCMNFISKEEFIMMVNISVLISIPLDNYDDFIYLSDLKQFFQMTPLLVNCLELLINTNFNKFFKIWHGEINKICMESLFLEPSWSSSAAVIMRCKIYFFYLRISKKLQFSYLSSTLGIDLEDIKEELTKLIISGQLNFEIDGDVIHFEDSSILQSIVNEISRNGTMINEVIDKLKNENTDLKDIIQGNPLMYSGGNNTATIINNESSDDMDIDEVNDRSDISDSEGGLFEC
Protein: Small nuclear ribonucleoprotein SmD1b (AtSmD1-b) (Q9SY09)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:26842463}. Nucleus, nucleolus {ECO:0000269|PubMed:26842463}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- Sm protein F
- Probable small nuclear ribonucleoprotein G
- Probable small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein SmD3b
- Small nuclear ribonucleoprotein SmD3a
- Pre-mRNA-processing-splicing factor 8A
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein E
Sequence:
MKLVRFLMKLNNETVSIELKNGTIVHGTITGVDVSMNTHLKAVKLTLKGKNPVTLDHLSVRGNNIRYYILPDSLNLETLLVEDTPRIKPKKPTAGKIPAGRGRGRGRGRGRGRGGR
Protein: Uncharacterized protein YJL144W (P47009)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Heat shock protein 42
- Protein OPI10
- Protein SIP18
- ATPase-stabilizing factor 15 kDa protein
- Protein GRE1
Sequence:
MLRRETSTIYRTHKKSNSSILRSQRDQTRVDSLVEESPMGDFGINNQPTQPGVIYYFVELTNLGIQENTSSNNNNNNNHGDDENGSRYGHGSSLGGDVHSRRCS
Protein: Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) (P10160)
Organism: Oryctolagus cuniculus (Rabbit)
Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P63241}. Nucleus {ECO:0000250|UniProtKB:P63241}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P63241}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63241}; Cytoplasmic side {ECO:0000250|UniProtKB:P63241}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. Nuclear export of hypusinated protein is mediated by XPO4. {ECO:0000250|UniProtKB:P63241}.
Interaction partners:
- Deoxyhypusine synthase
- Uncharacterized protein
- Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
- Uncharacterized protein
- Uncharacterized protein
- Small ribosomal subunit protein uS19
- U3 small nucleolar ribonucleoprotein protein IMP3
- Eukaryotic translation initiation factor 1A
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL13
Sequence:
MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDSGEEILITVLSAMTEEAAVAIKAMAK
Protein: DNA primase large subunit (Q5ZM06)
Organism: Gallus gallus (Chicken)
Interaction partners:
- DNA primase
- DNA polymerase.
- Pol_alpha_B_N domain-containing protein.
- DNA_pol_E_B domain-containing protein.
- DNA polymerase epsilon catalytic subunit
- DNA helicase
- Replication factor C subunit 3
- DNA replication licensing factor MCM3
- Cell division cycle 45.
- Proliferating cell nuclear antigen
Sequence:
MEFSSRARQRHLKLAGDRREPYPHSLQFYQEPPTESISLAEFESFAVDRLRLLKVVENLGVSYVKSGDAYKTKLEAELRKLKFPYRALAEDDYDARRKDHISHFILRLAYCQSEELRRWFLQQEMDLFRYRFHELTDSLRQKFLDHVNLSFEAISEDLKNELSNELYMSTPGLSMSKVKEQMFYKVGLSDAVDLFRARRVFIKDGFAFVPLKDIDAIVLNNYRKSLSKALALTARSLPSIQSDERLQPLLNHLSHSYVGPDYSVQKNTGKISLEHIDALSVKSFPLCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLEQALEFWKKEFIKGKVDADKFDKGYAYSIRHNYGKEGKRTDYTPYSCMKIIMSNPPSQGDYHGCPFRHSDPELLKQKLQSYKVPPSGVTQILELVKGMHYQLACQKYFELTHDVDDIGFSLNHPNQYFAESQRILSGGREVKKEPNHLGNSQQKNNSQESVNSNSAPTSSNTTTDAELEGLEAYFTED
Protein: Engulfment ABC transporter in the ovary, isoform B (Q0E8Q7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ced-12
Sequence:
MAGTFTPLFFVFLRKNLLYLQRNLLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRELYFPGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRGSCFAIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVNDEEIYHQIDDDDYIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMPNMEVISMDSHRLTYFGTLCSILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLMIFVLVVAYLYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLIIPYAFSFVRSWATSLAFVCFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEYTTTPRGTHAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCSERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVDTPDGSRNDAPLLAHYKRLQDHPPHRGLFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFLEQVIGIIDMYGGGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSRLEYYAVIVPIGMFFFMFYFISLPFREYANGFKQLQTMSRFTYWFAHFTFDMLILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPDFNLNHQFRIINENFITRRHPALIKGLISQDTFFAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEKRVTDLIKDPLNDHSLIVHNLRKRYGDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRLSGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQSTSRQTSVQRRPECSYV
Protein: DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) (Q9ESZ0)
Organism: Rattus norvegicus (Rat)
Function: Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P18887}. Chromosome {ECO:0000250|UniProtKB:P18887}. Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage. Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains. {ECO:0000250|UniProtKB:P18887}.
Interaction partners:
- DNA polymerase beta
- Bifunctional polynucleotide phosphatase/kinase
- Aprataxin
- Poly [ADP-ribose] polymerase 1
- X-ray repair cross-complementing protein 6
- DNA ligase
- DNA ligase 1
- Poly
- Aprataxin and PNK-like factor
- Nei endonuclease VIII-like 1
Sequence:
MPEISLRHVVSCSSQDSTHRAENLLKADTYRKWRSAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGATAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRIFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPYGLSFVKFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDDSANSLRPGALFFNRINKAASASASDPAGPSYAAATLQASSAASSASPVPKVGGSSSKLQEPPKGKRKLDLGLEDKKPPSKPSAGPPAPKRPKLPVPSRTPAATPASTPAQKAVPGKPRGEGTEPRGARAGPQELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTPDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCYRMRRRLPSRRYLMAGLGSSSEDEGDSHSESGEDEAPKLPRKRPQPKAKTQAAGPSSPPRPPTPEETKAPSPGPQDNSDTDGEQSEGRDNGAEDSGDTEDELRRVAKQREQRQPPAPEENGEDPYAGSTDENTDSEAPSEADLPIPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDYMSDRVQFVITAQEWDPNFEEALMENPSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA
Protein: T-complex protein 10A homolog 1 (T-complex protein 10A-1) (TCP10A-1) (TCP10-like) (Q8TDR4)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:14586771, ECO:0000269|PubMed:15910542}.
Interaction partners:
Sequence:
MLAGQLEARDPKEGTHPEDPCPGAGAVMEKTAVAAEVLTEDCNTGEMPPLQQQIIRLHQELGRQKSLWADVHGKLRSHIDALREQNMELREKLRALQLQRWKARKKSAASPHAGQESHTLALEPAFGKISPLSADEETIPKYAGHKNQSATLLGQRSSSNNSAPPKPMSLKIERISSWKTPPQENRDKNLSRRRQDRRATPTGRPTPCAERRGGV
Protein: Iroquois-class homeodomain protein IRX-3 (Homeodomain protein IRXB1) (Iroquois homeobox protein 3) (P78415)
Organism: Homo sapiens (Human)
Function: Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Iroquois-class homeodomain protein IRX-5
- Alpha-ketoglutarate-dependent dioxygenase FTO-)-demethylase FTO)
- Homeobox protein Nkx-2.2
- A-kinase anchor protein 11
- Oligodendrocyte transcription factor 2
- Homeobox protein SIX3
Sequence:
MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPDNPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
Protein: NAC transcription factor 56 (AtNAC056) (NAC domain-containing protein 2) (AtNAC2) (Protein NAC-REGULATED SEED MORPHOLOGY 1) (Q9LD44)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor of the NAC family (Probable). Together with NAC018/NARS2, regulates embryogenesis by regulating the development and degeneration of ovule integuments, a process required for intertissue communication between the embryo and the maternal integument.
Subcellular location: Nucleus {ECO:0000269|PubMed:18849494}.
Interaction partners:
- glucan endo-1,3-beta-D-glucosidase
- Kunitz trypsin inhibitor 3
Sequence:
MESTDSSGGPPPPQPNLPPGFRFHPTDEELVVHYLKRKAASAPLPVAIIAEVDLYKFDPWELPAKASFGEQEWYFFSPRDRKYPNGARPNRAATSGYWKATGTDKPVLASDGNQKVGVKKALVFYSGKPPKGVKSDWIMHEYRLIENKPNNRPPGCDFGNKKNSLRLDDWVLCRIYKKNNASRHVDNDKDHDMIDYIFRKIPPSLSMAAASTGLHQHHHNVSRSMNFFPGKFSGGGYGIFSDGGNTSIYDGGGMINNIGTDSVDHDNNADVVGLNHASSSGPMMMANLKRTLPVPYWPVADEEQDASPSKRFHGVGGGGGDCSNMSSSMMEETPPLMQQQGGVLGDGLFRTTSYQLPGLNWYSS
Protein: Beta-defensin 131A (Beta-defensin 31) (DEFB-31) (Defensin, beta 131) (P59861)
Organism: Homo sapiens (Human)
Function: Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Beta-defensin 127
- Defensin beta 118
- Beta-defensin 121
- Beta-defensin 134
- Beta-defensin 128
- Beta-defensin 129
- Beta-defensin 110
- Beta-defensin 126
- Beta-defensin 130A
- Beta-defensin 123
Sequence:
MRVLFFVFGVLSLMFTVPPARSFISNDECPSEYYHCRLKCNADEHAIRYCADFSICCKLKIIEIDGQKKW
Protein: Stem-loop-binding protein 2 (Zgc:158856) (A1L2F4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Lymphocyte cytosolic protein 2a.
- 3'-5' exoribonuclease 1
- WD repeat-containing protein 55
- Histone H2A
Sequence:
MTTRIESLLQSPFESRLGLPLHLWPTDVAQDFSSKTLSLPCSPEPWLLPGCSSVYDSLVSCSKTPLSASQNGEKPSAVQKPRRSSILERCILRMSTASVAVGTEDLDGVKRSPSRGKWYPHNADPSHFEINEAVLKRRQKQIQYGKNTCGYQNYVQQVPKRLRVPGIHPSTPNKYRKYSRRSWDMQVRLWRRALHAWDLPSASQNDTEGQDPVDQLQSLLEKMNTELSDGGEKEDMKWEMAPDSMTSIISQPSEISTDGPWLASNALQIGASSHLNQSSQHGLGYTFSNQQTAQENVLGWLRFLLETDHNQTQAPLLPEEPFWRIA