wanglab/gogpt-training-data huggingface dataset:
Protein: Protein CBFA2T3 (Eight twenty one protein 2) (MTG8-related protein 2) (Protein ETO-2) (O54972)
Organism: Mus musculus (Mouse)
Function: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (By similarity). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10022820}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10022820}. Golgi apparatus membrane {ECO:0000250}.
Interaction partners:
- LIM domain-binding protein 1
- T-cell acute lymphocytic leukemia protein 1 homolog
- Erythroid transcription factor
- Runt-related transcription factor 1
- Transcription factor PU.1
- Zinc finger protein GLIS2
- Rhombotin-2
- Nuclear receptor corepressor 2
- Nuclear receptor corepressor 1
Sequence:
MSQASTTTLESGALLSGPRGLQYGSPAHRKEKAAAMPDSPAEVKTQPRSTPPSMPPPPPTSSQGATRPPSFTPHTHGEDGPATSLPHGRFHGCLKWSMVCLLMNGSSHSPTAIHGAPSTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHAKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASATSPVDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPDHLSKRSCTLSPAQRCSPSNGLPHPTPPPPPHYRLEDMAMAHHFRDSYRHPDPRELRERHRPLAIPGSRQEEVIDHRLTEREWAEEWKHLNSLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWIRCYSDSEEGKKGPTPISARSLNSCSGPEGSQLDVHRDFTPRTLSGYMPEEIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHKDWEKHHHVCGQSLQGPAAAVADPLPGQPDATASPSEAGSAGPSRPCSPGPPGPLDAAVPR
Protein: Lymphotoxin-alpha (TNF-alpha) (TNF-beta) (Tumor necrosis factor) (Tumor necrosis factor ligand superfamily member 1) (Q4W898)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- Tumor necrosis factor receptor superfamily, member 1a.
- Tumor necrosis factor receptor superfamily member 1B precursor
- Interleukin-1.
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Receptor
- Interleukin family protein
- Tumor necrosis factor, alpha-induced protein 3.
- Receptor-interacting serine-threonine kinase 3.
- Mitogen-activated protein kinase kinase kinase 7.
- TGF-beta-activated kinase 1/MAP3K7-binding protein 1.
Sequence:
MVRYETTLVDMEAGVGGVYQTTVAPVPVNSSRSWIWKTLAAVAFVGLCVVAAFFFTWHVMKPNEEGQKPNREHLKQQITTPSASSDHGKVLKQIAQSTKAAIHLHGDPSGQSLKWVGGVDQAFQQGGLRLENNEIIIPKDGLYFVYSQVSYETLCVEDVEGDGQKYLSHTINRYTDAVREKMPLQNSANSVCQSLDGKTSYSTIYLGAVFDLFGDDRLSTHTTRVGDIENNYAKTFFGVFAL
Protein: Ubiquitin carboxyl-terminal hydrolase 12/46 homolog (EC 3.4.19.12) (Ubiquitin-specific protease 12/46) (Q9VCT9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- WD repeat-containing protein 48 homolog
- WD repeat-containing protein 20 homolog
- Protein phosphatase PHLPP-like protein
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin carboxyl-terminal hydrolase 30 homolog
Sequence:
MGANVSQLEREIGSDLFPPNEHYFGLVNFGNTCYSNSVLQALYFCKPFREKVLEYKAKNKRPKETLLSCLADLFYSIATQKKKVGSIAPKKFITRLRKEKEEFDNYMQQDAHEFLNFLINHINEIILAERNAGPSNGNPKATNQGGSTSAMASSIASKSSSTSNSNSNSNSTTNSNGNSSNSTGSLNANTSVLDASGSLTATTTPIISGNGTGTNGANSEPTWVHEIFQGILTSETRCLNCETVSSKDENFFDLQVDVDQNTSITHCLRCFSNTETLCSDNKFKCDNCCSYQEAQKRMRVKKLPMILALHLKRFKYMEQFNRHIKVSHRVVFPLELRLFNTSDDAVNPDRLYDLTAVVIHCGSGPNRGHYISIVKSHGLWLLFDDDMVDKIEASTIEDFYGLTSDIHKSSETGYILFYQSRDCA
Protein: MsrB domain-containing protein (Q586K2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHSHLQNTFRRTVQLAVKYRAVSKCRRIHTGPIPQSMLWLAGARERHIKRGADTSSLTNDVCHTPQGSECARQQQQQREQHHKRLPCAKGSGPPTLADVPPLVLDPPFTPVGGETAVMERLHRMPVNGTDAERYVVSYNCRECSSTLFSSNDFTVASTLGSHKDGWPCFTAPASAKALQLRGLLQRSAVGRGRGAMAADSNRGDLSSSREFISSPLTATLAARGLPIEGEMTRTTRSGRCELLKPKTWRETCLRDVNKRSDPALLEGCCSTCGNAVCRVVTTRGGAVKYVVNPTAVTAELIGEEEEPLSRQRN
Protein: LIM domain kinase 1, isoform F (EC 2.7.11.1) (LIM-kinase 1 isoform F) (E1JJM8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAEQCCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFCAQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEKENMVIKPQDIPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEERRNLTPDTESKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVRDLNTYSDVDSSCDTSLNYHDVNNLPAAQEDENTVKPGKEELLEESTNKPSNQESQHHRLAIDDMRTRLNQCRSKFEHLEEASRRNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRTQRINQTPIFGRKNPPVAIVGQKLQHAESLEDLASSGVAKQLATPAPKRSKATATTKGGQSSNPPLFLPPSLNISVALNSNGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPSAQQQRTSSNHRLPMCNNKGKTLKPLPSRTGSQGIPASNCVSPTRSSRPGSPTKHLAQRHTAATAQRLTNAAATHQQQHQQQSSKTTRLNILSPEKVHRLGARLTDQKQKMREEAAATASSVGGAGCAAGTAAGSLNGHRTIGSSGTPNSAVGERRRRAAPSPPVRTHFNTRC
Protein: E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) (Q8WVD3)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
Subcellular location: Chromosome {ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}. Note=Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057). {ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 K
- Citrate synthase, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- Serine/threonine-protein kinase NLK
Sequence:
MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
Protein: 60S ribosome subunit biogenesis protein NOP8 (Nucleolar protein 8) (Q08287)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for 60S ribosomal subunit synthesis. May be involved in assembly reactions occurring within late pre-ribosomal particles.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:9891085}.
Interaction partners:
- Nucleolar pre-ribosomal-associated protein 1
- Nucleolar pre-ribosomal-associated protein 2
- Ribosome assembly protein 3
- ATP-dependent RNA helicase DBP6
- 60S ribosome subunit biogenesis protein NIP7
- ATP-dependent RNA helicase DBP9
- ATP-dependent RNA helicase DBP7
- Nucleolar protein 58
- Ribosome biogenesis protein MAK21
- H/ACA ribonucleoprotein complex subunit CBF5
Sequence:
MDSVIQKRIFVGNIFHNADDCYSELLDRFGKFGDCQDFQFEKHNHFAFIDIRFNDEADFNKLRKSFNNVKFKGNILKVDEAKPNWESTWAVQHAKDLKEDIILNAKMKKKNWQHYKKMENVAKSWKDHKEVIAGRMREAPRKRSQLRNITFRINVNGSLKVYKCYKTKLWGYERNKELNDLVYKFTNNFWKNGYNHIVDRLDYSRAVKTVRFKNGLKQLTVSKDENVCSGEMDSDENMSEEEKEKNNVILNDLLKDFDFDKPMTLNDSDEELLTEQRKGEEEEEEEEEKEVNAPEYENVNKTKDQSTLPQEKPEERKEQDEGDGQEDNEFIPTFTKEIGQGTISNTETLRNLFNPNEAEPVSQFKLIEDSDNDIDHAKDVDVNQLEEEVSKSSDTLGLTSAPVPHVSRDKDNKNFLFFPHLQSPFLVGQTQLSKVRAPGRETMLSNWDEEFWANRGNWTRDMRRKMKDALKHRKRKQSKSGLLL
Protein: COP9 signalosome complex subunit 4 (Dch4) (Signalosome subunit 4) (Q9V345)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:10531038}. Nucleus {ECO:0000305|PubMed:10531038}.
Interaction partners:
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 7
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 8
- COP9 signalosome subunit 1a
- COP9 signalosome complex subunit 1b
- Ubiquitin-like protein NEDD8
- Cullin-4A
Sequence:
MAANYGISTAALRSQLMGLINFTGTHKDQADKYRQLLKTVLTNTGQELIDGLRLFVEAIVNEHVSLVISRQILNDVGSELSKLPDDLSKMLSHFTLEKVNPRVISFEEQVAGIRFHLANIYERNQQWRDAATVLVGIPLETGQKQYSVECKLGTYLKIARLYLEDNDSVQAELFINRASLLQAETNSEELQVLYKVCYARVLDYRRKFIEAAQRYNELSYRKIVDQGERMTALKKALICTVLASAGQQRSRMLATLFKDERCQHLPAYGILEKMYLERIIRRSELQEFEALLQDHQKAATSDGSSILDRAVFEHNLLSASKLYNNITFEELGALLDIPAVKAEKIASQMITEGRMNGHIDQISAIVHFENRELLPQWDRQIQSLCYQVNSIIEKISVAEPDWMDNLN
Protein: Glycoprotein UL18 (P08560)
Organism: Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Function: Plays a role in the protection against host NK cell cytotoxicity by interacting with and modulating the activity of the host inhibitory leukocyte Ig-like receptor 1/LILRB1, which is expressed on monocytes, dendritic cells, as well as subsets of T and NK cells. UL18 exerts an inhibitory effect on LIR-1+ NK cells, while it stimulates LIR-1- NK cell. These modulations prevent lysis of the infected cells by NK cells.
Subcellular location: Host membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MMTMWCLTLFVLWMLRVVGMHVLRYGYTGIFDDTSHMTLTVVGIFDGQHFFTYHVNSSDKASSRANGTISWMANVSAAYPTYLDGERAKGDLIFNQTEQNLLELEIALGYRSQSVLTWTHECNTTENGSFVAGYEGFGWDGETLMELKDNLTLWTGPNYEISWLKQNKTYIDGKIKNISEGDTTIQRNYLKGNCTQWSVIYSGFQPPVTHPVVKGGVRNQNDNRAEAFCTSYGFFPGEINITFIHYGDKVPEDSEPQCNPLLPTLDGTFHQGCYVAIFCNQNYTCRVTHGNWTVEIPISVTSPDDSSSGEVPDHPTANKRYNTMTISSVLLALLLCALLFAFLHYFTTLKQYLRNLAFAWRYRKVRSS
Protein: CVg1 protein (Growth differentiation factor 3) (Q98950)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Activin receptor type-2B
- Activin receptor type-2A
- Receptor protein serine/threonine kinase
- Cryptic protein
- Left-right determination factor.
Sequence:
MWWPLPACASFGAGLAWALLTVALGMDLSLQESLLLKSLGLSAKPSPKIPIPVPSVLWRIFQKRRSPPATNRDPVDGCRVEEFNVPGNIIRVFADQGRFIHSTQPHPLLCLQKRLYFNLSVLEEDERLTMAQLEIKFSHNSYHSPGRGGGFELRLYRSCPVPLRGTPSLERGRKLLLEQSFARLHKSLLFNLSDVAKDWTTHSRNLGLVLEIAVSGDGASAPGSTGPQSPCAGIDSFMDTSLLVVTLSQQQCRASRRRRSAYNVPVTPSNLCKPRRLYISFSDVGWENWIIAPQGYMANYCLGECPFPLTAELNSTNHAILQTMVHSLDPEGTPQPCCVPVRLSPISILYYDNSDNVVLRHYEDMVVDECGCR
Protein: Putative purine permease C1399.01c (Q9HE12)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- SRP-independent targeting protein 3 homolog
- Protein transport protein got1
- DNA polymerase subunit delta-2
- Dihydroorotate dehydrogenase
- Orotate phosphoribosyltransferase
- Orotidine 5'-phosphate decarboxylase
- Uricase
- Adenine phosphoribosyltransferase
Sequence:
MSESIQDQDHEKTTIIEKTRRFVLSIFTKDFWIGDYDYSFLLPAIPFTKQKPKSPPFFSLNAKVPVLLALLLGFQHALAMVGGVTSPPRIIAASANLTTEQTNYLVSAGLISSGIMTLIQIARVHIPKTKYYIGTGMLSVLGISFTSVSVAPKVLSQMYENGYCPKDENGTKLPCPDGYGAFLATACVCSLLEIFMSFIPPRILKRLFPPIVTGPVVLLIGTSLISSGLNDWAGGEGSCTGRPTEAEAPGYSLCPSDTSPHALGWGSAQFIGLGFSVFATIIIIERFGPPLMKTTSVVLGLVVGMIISAATGYWDHSIIDAAPVVTFNWVHTFRLRIYGPAVLPMLALYIVNMMEAIGDIGATSDVSMLEVDGPAFDARVQGGILGDGLASLIASLMTTTPLTTFAQNNGVISLTKCANRRAGFFCAVILFFMGLFAKFAAVFVAIPSPVLGGMTTFLFSSVAVSGIAIISQIPFNRRNRFILTASMTLGMGAILVPDWFTYFFEYSGPNKALVGFLDAITLVMENGFAIGAFISIFLNLILPYEFDPDLTNDSPGLSTTNGVNNGIVEVRGIDPNDSLSNTDTEYANENKKDEVDVDKVV
Protein: Phosphatidylinositol 4-kinase gamma 2 (AtPI4Kgamma2) (PI-4Kgamma2) (PI4K gamma 2) (EC 2.7.1.67) (Q9SGW8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Subcellular location: Membrane {ECO:0000269|PubMed:23323832}; Peripheral membrane protein {ECO:0000269|PubMed:23323832}; Cytoplasmic side {ECO:0000269|PubMed:23323832}.
Interaction partners:
- E3 ubiquitin-protein ligase UPL4
- Protein NBR1 homolog
- E3 ubiquitin-protein ligase PRT1
- E3 ubiquitin-protein ligase UPL3
- E3 ubiquitin-protein ligase MIEL1
- E3 ubiquitin-protein ligase UPL5
- E3 ubiquitin-protein ligase RHA2B
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- Large ribosomal subunit protein eL42z/eL42y
Sequence:
MSVADVALSPIHRGSAFAVGGFGQSTTTHYSVKSVLVFLSVSGSTMPMLILESDSIAEVKLRIQTCNGFRVRRQKLVFSGRELARNASRVKDYGVTGGSVLHLVLKLYDPLLVTVITTCGKVFQFHVDRRRNVGYLKKRISKEGKGFPEVDDQEILFKGEKLDDNRIIDGICKDGNSVIHLLVKKSVEDTVKREEDTATGKDSLLEPVVLNPDVKLPEVLEDMIDRTVDGLNKGSPPVRSAEGTGGTYLMQDSSGLNYVSVFKPMDEEPMAVNNPQQLPVSSDGQGLKRGTRVGEGATREVAAYLLDHPKSGLRSVSKEVMGFAGVPPTAMVRSSHKVYNYPNGFSSCATKDAKVGSLQMFMKNNGSCEDIGPGAFPVEEVHKICVFDIRMANADRHAGNILTGKSEEGKTLLIPIDHGYCLPENFEDCTFEWLYWPQAKLPFSADTIDYINSLDSEQDIALLQLHGWNVPEAVSRTLRISTMLLKKGVERNLTPYQIGSVMCRETVNKDSAIEEIVREAHNSVLPASSEATFLEAVSVAMDRRLDELTK
Protein: Fluoroquinolones export permease protein Rv2686c (P9WJB3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Fluoroquinolones export ATP-binding protein Rv2688c
- Fluoroquinolones export permease protein Rv2687c
- Multidrug efflux pump Tap
- Conserved protein
- Transmembrane protein
- Anti-sigma-M factor RsmA
Sequence:
MRAISSLAGPRALAAFGRNDIRGTYRDPLLVMLVIAPVIWTTGVALLTPLFTEMLARRYGFDLVGYYPLILTAFLLLTSIIVAGALAAFLVLDDVDAGTMTALRVTPVPLSVFFGYRAATVMVVTTIYVVATMSCSGILEPGLVSSLIPIGLVAGLSAVVTLLLILAVANNKIQGLAMVRALGMLIAGLPCLPWFISSNWNLAFGVLPPYWAAKAFWVASDHGTWWPYLVGGAVYNLAIVWVLFRRFRAKHA
Protein: Protein HdeD (P0AET5)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Acid stress chaperone HdeB
- Acid stress chaperone HdeA
- Glutamate decarboxylase alpha
- Glutamate/gamma-aminobutyrate antiporter
- Glutamate decarboxylase beta
- Outer membrane protein Slp
- Transcriptional regulator GadE
- Putative magnesium transporter YhiD
- HTH-type transcriptional regulator GadX
- HTH-type transcriptional regulator DctR
Sequence:
MLYIDKATILKFDLEMLKKHRRAIQFIAVLLFIVGLLCISFPFVSGDILSTVVGALLICSGIALIVGLFSNRSHNFWPVLSGFLVAVAYLLIGYFFIRAPELGIFAIAAFIAGLFCVAGVIRLMSWYRQRSMKGSWLQLVIGVLDIVIAWIFLGATPMVSVTLVSTLVGIELIFSAASLFSFASLFVKQQ
Protein: Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1) (Q9R1J8)
Organism: Rattus norvegicus (Rat)
Function: Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:10455179}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10455179}. Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG). {ECO:0000269|PubMed:10455179}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase B
- Cartilage associated protein
- Cartilage associated protein
- Collagen alpha-1
- Collagen alpha-2
- Serpin H1
- peptidylprolyl isomerase
- Trimeric intracellular cation channel type B
- Collagen alpha-1
- Protein disulfide-isomerase
Sequence:
MVAVAAAAASRATAESEPEWNVAAPDLLYAEGTAAYARGDWPGVVLNMERALRSRAALRALRLRCRTRCATELPWAPDLDLGPASSLNHDPGAAALHDLRFFGALLRRAACLRRCLGPPSAHLLSEELDLEFNKRSPYNYLQVAYFKINKLEKAVAAAHTFFVGNPEHMEMRQNLDYYQTMSGVKEEDFKDLEAKPHMHEFRLGVRLYSEEKPLEAVPHLEAALQEYFVADEECRALCEGPYDYDGYNYLDYSADLFQAITDHYVQVLSCKQNCVTELASHPSREKPFEDFLPSHYNYLQFAYYNIGNYTQAIECAKTYLLFFPNDEVMSQNLAYYTAVLGEEEASSISPRENAQEYRHRSLLEKELLFFAYDIFGIPFVDPDSWTPEEVIPKRLQEKQKSERETAVRISQEIGNLMKEIETLVEEKTKESLDVSRLTREGGPLLYEGINLTMNSKVLNGSQRVVMDGVISDDECQELQRLTNAAATSGDGYRGQTSPHTPNEKFYGVTVLKALKLGQEGKVPLQSAHMYYNVTEKVRRVMESYFRLDTPLYFSYSHLVCRTAIEESQAERKDSSHPVHVDNCILNAESLVCIKEPPAYTFRDYSAILYLNGDFDGGNFYFTELDAKTVTAEVQPQCGRAVGFSSGTENPHGVKAVTRGQRCAIALWFTLDPRHSERDRVQADDLVKMLFSPEEVDLPQEQPLPDQQGSPKPGEESLSDRESQPKDEL
Protein: T-complex protein 1 subunit theta (CCT-theta) (A0A0R4IJT8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- T-complex protein 1 subunit epsilon
- Tcp1 protein.
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit gamma.
- Chaperonin-containing TCP1, subunit 6A
- T-complex protein 1 subunit eta
- Chaperonin-containing TCP1, subunit 2
- Chaperonin-containing TCP1, subunit 2
- Protein FAM161A
- MKKS centrosomal shuttling protein
Sequence:
MALHVPKAPGFAQMLKDGAKHYSGLEEAVFRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRMGLSVSEVIEGYEMACKKALEILPDCVCSSAKNLHDLEEATAMIRSAVMSKQYGNEDFLANLIAQACVSIFPESGSFNVDNVRVCKILGCGLNSSTMLHGMVFKKEAEGDVTSVKDAKIAVFSCPFDCTVTETKGTVLIKNADELMNFSKGEEDLMEAQVKAIADSGASVVVTGGKVADMALHYANKYKLMVVRLNSKWDLRRLCKTVGATALPRLTSPTPEEMGRCDSVYLSEVGDTQVVVFKHDKEDGAISTLVIRGSTDNLMDDIERAIDDGVNTFKVLVRDARLCPGAGATEIELAKHITSYGESCPGLEQYAIKKYAEAFEALPRALAENSGVKGNELISKLYATHHEGNKNSGFDIEGEGPAVRDMMEAGILDPYLVKYWGIKLATNAAITVLRVDQIIMAKPAGGPKAPKQQGHWDKDGWDDEPDKFDAHH
Protein: Protein MGARP (Corneal endothelium-specific protein 1) (CESP-1) (Hypoxia up-regulated mitochondrial movement regulator protein) (Mitochondria-localized glutamic acid-rich protein) (Ovary-specific acidic protein) (Q8VI64)
Organism: Mus musculus (Mouse)
Function: Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology. Plays an inhibitory role during neocortex development by regulating mitochondrial morphology, distribution and motility in neocortical neurons.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19325000, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20107910, ECO:0000269|PubMed:24323429}. Mitochondrion outer membrane {ECO:0000269|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000305|PubMed:19528298}; Cytoplasmic side {ECO:0000305|PubMed:19528298}. Mitochondrion inner membrane {ECO:0000269|PubMed:31202457}; Single-pass type IV membrane protein {ECO:0000305|PubMed:31202457}; Cytoplasmic side {ECO:0000305|PubMed:31202457}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion. {ECO:0000269|PubMed:19528298}.
Interaction partners:
Sequence:
MYLRRAVSKTLALPRRAPPGPAPLGKDASLRRMSSRKFPGTSGSNMIYYLVVGVTVSAGGYYTYKALTSKQVRRTEHVAEPKEQTKAELQPLPGEKEEHVAEAEQVCSEPGDTAVTEAESVDAEEVPEAAVVLPEESQASAPSEVPAEAAVVEASLSSSEPELKITEASLVETTESVPESTQEVESAAPDQDDVCNEGADTSQEGADTSQEGADTSQEGADTTKEEADNSKEAEGTTTEDPRSISEESAELEESPPLGSEPPAQPESQEEETQVTEETASPQG
Protein: Heat shock protein HSP 90 (Eukaryotic peptide initiation factor 2 kinase, alpha-chain-associated phosphopeptide) (P11500)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MPEEVQTQDQPMETFAVQTFAFQAEIAQLMSLIYESLTDPSKLDSGK
Protein: Spermidine/spermine N(1)-acetyltransferase (SSAT) (Protease synthase and sporulation negative regulatory protein PAI 1) (Spermidine N(1)-acetyltransferase) (SAT) (EC 2.3.1.57) (P21340)
Organism: Bacillus subtilis (strain 168)
Function: Involved in the protection against polyamine toxicity by regulating their concentration. Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It possesses N1-acetyltransferase activity toward polyamine substrates including spermidine, spermine, aminopropylcadaverine, norspermidine, homospermidine, N(8)-acetylspermidine, diaminopropane and agmatine.
Interaction partners:
- Protease synthase and sporulation protein PAI 2
- Uncharacterized HTH-type transcriptional regulator YybA
- Uncharacterized N-acetyltransferase YjcF
Sequence:
MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESAFNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSFQKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDEEQTDLIMAKTLI
Protein: Dof zinc finger protein MNB1A (P38564)
Organism: Zea mays (Maize)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence at the MNF1-binding site.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA-binding protein MNB1B
Sequence:
MQEASSAAAAGAEPGRRAAQHQFAGVDLRRPKGYAAPAPAPAVGEGDPCPRCASRDTKFCYYNNYNTSQPRHFCKGCRRYWTKGGTLRNVPVGGGTRKKPSSSSSSSSYVAAADADRQPKKKPASKKRRVVAPAPELATAADPGKTATTTTTTSEITTETGALEDSDSLAHLLLQPGTEDAEAVALGLGLSDFPSAGKAVLDDEDSFVWPAASFDMGACWAGAGFADPDPACIFLNLP