wanglab/gogpt-training-data huggingface dataset:
Protein: AtfA (C8VJ72)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Mitogen-activated protein kinase hog1
- CPCA
- Transcription factor
- Mitogen-activated protein kinase mpkC
- AP-1-like transcription factor napA
Sequence:
MSAAVASAVSTTLPSNPTAHSSPMDAKKNSVKMDNEASSETKEQKTDGEPQTSLAPPSRPNPSAATDTPDYFNSVHNPFALEPNPFEQSFGGGSGETPGKSILPPVASITSPALPGTSSAGGAYNWSNSLRSGPLSPAMLAGPAGGSDYFDSIGRGFPTPNESSLRTGLTPGGGGSMFPAPSPNSQALLNQLQNGGATPSTIEFHRTALNVKKNGIAPTSNPTGEGDQVPQNITTTMDIKPAQPATVDFGPHDAADAANGLFMLAKGGQSTANQFAAVSNQTAIPPQTLQTSEILQDQNAARRQSVNVNGVANTREPSGDGSEQSEQAKPARGRGKRNTSTKASSTGNRRKTDDSTQGSNKRTKLNNGAASTESPSEGESEEEEQQPAQKKKAGDTKKMTDEEKRKNFLERNRVAALKCRQRKKQWLANLQAKVELFTSENDALTTTVTQLREEIVNLKTLLLAHKDCPVSQAQGLIWNPNPPYT
Protein: S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) (Q9V813)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03155}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03155}.
Interaction partners:
- Spermidine synthase, isoform A
- Methylthioribose-1-phosphate isomerase
- Purine nucleoside phosphorylase
- Adenine phosphoribosyltransferase
- Nucleolar protein 58
- Adenosylhomocysteinase-like 2
- Serine/threonine-protein kinase RIO1
- Deoxyhypusine hydroxylase
- Spermine synthase, isoform D
- Adenosylhomocysteinase
Sequence:
MITIKCKDTNLDPLPVKIGIIGGSGLDDPDILEQRQERVVETPYGEPSDALIEGEINGVQCVLLARHGRKHDIMPSNVNYRANIWALRDVGCTHLIVSTACGSLREEIKPGNLVVPHDFIDRTTKRLQTFYDGKAQSPRGVCHLPMFPAFSERTRNILLQAAKELEIPAHDKATIVTIEGPRFSSRSESHMFRQWGGDLINMTTCPEVVLAKEAGLLYGSVAIATDYDCWRMGCEGVNVQDVLRTFAENVIKVKKILVNAVGRIAKEDWSEDILNAKQCVCNNTMSGAM
Protein: Mx2 protein (Myxovirus resistance 2) (Q98991)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MNNTLNQHYEEKVRPCIDLIDSLRSLGVEKDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLELKMKRKKEGEEWHGKISYQDHEEEIEDPSDVEKKIREAQDEMAGVGVGISDDLISLEIGSPDVPDLTLIDLPGIARVAVKGQPENIGEQIKRLIRKFITKQETINLVVVPCNVDIATTEALKMAQEVDPEGERTLGILTKPDLVDKGTEETVVDIVHNEVIHLTKGYMIVKCRGQKEIMERVSLSEATEREKAFFKEHAHLSTLYDEGHATIPKLAEKLTLELVHHIEKSLPRLEEQIEAKLAETHAELERYGTGPPEDSAERMYFLIDKVTAFTHDAINLSTGEELKSGVRLNVFSTLRKEFGKWKLHLDHSGENFNQRIEGEVADYEKTSRGRELPGFINYKTFEVMVKDQIKQLEEPAVKKLNQISDAVREVFLLLAQSSFIGFPNLLKSAKTKIEAIKQVNESTAESMLRTQFKMEMIVYTQDSTYSHSLSERKREEEDDRPLPTIKIRSTIFSTDNHATLQEMMLHLKSYYRISSQRLADQIPMVIRYLVLQEFASQLQREMLQTLQEKDNIEQLLKEDFDIGSKRAALQNKLKRLMKARSYLVEF
Protein: Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC 1.1.1.8) (A7LPE5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSPKKVTIIGSGNWGSAIARIVGSTTKSFPDEFDPTVRMWVFEEIVNGEKLSEVINNRHENIKYLPGKVLPNNVGVSTEKRGGLKLISEEIKEILKIEVSVLMGANLAPEVANDNFCEATIGCKRKAEDGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVEHYYPGSNLQTFFESCGIADLITTCYGGRNRKVCEAFVKTGKSMAEVEKELLNGQSAQGPLTAEEVYLMMHKTGLDAKFPLFTAVHKICAGEMKPAELVDCLRNHPEHM
Protein: Regulator of Vps4 activity in the MVB pathway protein (Unknown protein) (Q9FX63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At2g44240/F4I1.5
- Large ribosomal subunit protein P2z
- DNA polymerase V family
- At2g10940/F15K19.1
- At4g14145
- Protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5
- NADP-dependent alkenal double bond reductase P2
Sequence:
MGKKLDALLGRSFKTNKFKSLITLALTRLSILKNQRQARLSQAISDVTELLKLGQHEHAYHRVDQVVKDQNTLDVLFFIHGYFTLCLDRIHLFEHNRDCPEELLEAVSGLLFAASRIGEFPELQEIRNVLISRFGKDLAARSIELRSNCGVDPKIIQKLSTRPPPKEVRMKALKEIAAENNIVLKLDQASTSTEGTTNMQGTSDVSKTKLTSKDGRGEGYGLSDSVKRGKKKYKDVADAAQAAFESAAHAAEAAQAAVELSQFSPRGHDSPGNIGGENSFHGSENKESEQEQEGNDDSSEGEGDVMSESKRSMSDSEDIIDVPVMSFREDPVKLLEKDTIIYDSEEETQPSVETITISKSKDEQNRMVGSNRADTRHVDHMVRSIEDPIMRKAGLKGPVSVRTRQVRGY
Protein: Telomerase-associated protein of 50 kDa (p50) (D2CVN8)
Organism: Tetrahymena thermophila (strain SB210)
Function: Tethering component of the holoenzyme telomerase ribonucleoprotein (RNP) complex. Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER. In the telomerase holoenzyme complex, acts as a hub that anchors the two heterotrimeric subcomplexes with the catalytic core.
Subcellular location: Chromosome, telomere {ECO:0000305}.
Interaction partners:
Sequence:
MKLLLQNQNIFQKLKNTLNGCIKKFYDTYQDLEQMQKFEMIVEDKLLFRYSCSQSEMFSAQIQAHYLEKRVLQLTDGNVKYIVNFRDKGVLDKANFFDTPNNSLVIIRQWSYEIYYTKNTFQINLVIDEMRCIDIITTIFYCKLELDFTQGIKGISKSSSFSNQIYEYSAQYYKAIQLLKKLLINDSYISELYNSTKSKQQPRLFIFQSFKPKMNLAEQNLSRQFEQCQQDDFGDGCLLQIVNYTHQSLKQIENKNNSNQIVNGQNEISKKKRVLKSNEDLYKISLQKQLKIFQEEEIELHSQSTIRNQTNQQLETFESDTSKRNSEKILHSINELNTSKQKVNQMNSSQHQIQKLENNNLNKNILNQINENDIKNELEERQQQHLTQSFNSKAQLKKIITLKKNQDILLFKPQEQEGSKKY
Protein: Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) (Q05175)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Associated with the membranes of growth cones that form the tips of elongating axons.
Interaction partners:
- Myristoylated alanine-rich C-kinase substrate
Sequence:
MGSKLSKKKKGYNVNDEKAKDKDKKAEGAGTEEEGTQKESEPQAAADATEVKESAEEKPKDAADGEAKAEEKEADKAAAKEEAPKAEPEKSEGAAEEQPEPAPAPEQEAAAPGPAAGGEAPKAGEASAESTGAADGAPQEEGEAKKTEAPAAGPEAKSDAAPAASDSKPSTEPAPSSKETPAASEAPSSAAKAPAPAAPAAEPQAEAPVASSEQSVAVKE
Protein: Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2) (Q12891)
Organism: Homo sapiens (Human)
Function: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11296287}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11296287}.
Interaction partners:
- CD44 antigen
- Beta-glucuronidase
- Alpha-L-iduronidase
- Arylsulfatase B
- Macrophage-stimulating protein receptor
- Hyaluronan mediated motility receptor
- C-Jun-amino-terminal kinase-interacting protein 4
- Hyaluronan synthase 2
- WW domain-containing oxidoreductase
- Transforming growth factor beta-1 proprotein
Sequence:
MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
Protein: Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) (P16610)
Organism: Rattus norvegicus (Rat)
Function: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Protachykinin-1
- Tachykinin-3
- Tachykinin-4
Sequence:
MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMTGDMTHSEATNGQVGSPQDGEPAGPICKAQA
Protein: Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) (Q3U0M1)
Organism: Mus musculus (Mouse)
Function: Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000305|PubMed:15951441}. Note=Processes and cell bodies of neurons.
Interaction partners:
- Trafficking protein particle complex subunit 10
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 1
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit 2
- Trafficking protein particle complex subunit 3
- Trafficking protein particle complex subunit 4
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit 6A
- Trafficking protein particle complex 8
Sequence:
MSVPDYMQCAEDHQTLLVVVQAVGIVSEENFFRIYKRICSVSQLSVRDTQRALFIRYRHHYPPENNEWGDFQTHRKVVGLITITDCFSPKDWPQTFEKFHVQKEIYGSTLYDSRLFVFGLQGDVAEQPRPDVAFYPNYDDCDSVEKRIEDFIESLFIVLESKRLDRATDKSGDKIPLLCVPFEKKDFVGLDTDSRHYKKRCQGRMRKHVGDLCLQAGMLQDALVHYHMSVELLRSVNDFLWLGAALEGLCSASVIYHYPGGTGGKTGARRLQGSSLPSEAANRHRPGAQEVLIDPGALTTNGINPDTSTEIGRAKNCLSPEDIIDKYKEAISYYSKYKNAGVIELEACVKAVRVLAIQKRGMEASEFLQNAVYINLRQLSEEEKIQRYSILSELYELIGFHRKSAFFKRVAAMQCVAPSIAEPGWRACYKLLLETLPGYSLSLDPKDFSKGTHRGWAAVQMRLLHELVYASRRMGNPALSVRHLSFLLQTMLDFLSDQEKKDVTQSLENYTAKCPGTMEPITLPDGLTLPPVPFTKLPIVRCVKLLSLPTSLRPHKVKSLLGQSMSTKSPFIYSPIIAHNRGEERNKKIDFQWVQGDVCEVQLMVYNPMPFELRVENMGLLTSGVEFESLPAALSLPAESGLYPVTLVGVPQTTGMITVNGYHTTVFGVFSDCLLDNLPGLKTGGSTVEVIPALPRLQISTSLPRSARSLQPSAGDEIATNVSVQLYNGETQQLAVTLENIGLEPLEQLEVTSKLLTTKEKLYGDFLSWKLEETLAQFPLQPGKVATFTINIKAKLDFSCQENLLQDLSDDGISVSGFPLSSPFRQVVRPRVESRPTNPSEGSKTGDLGHVKTLEAVLNFKYSGGPGHVEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVCARNNSELVLHASECQRMAIQVDKFNFESVPESPGEKGHFANLKQLEEERQEARGLEISSKLDIRWRIPSLKRSGEASVEGLLNQLILEHLQLAPLQWDVLVDGQPCDCEVAAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDVISFVGSSTFYLDTVQPSGQSTCLGALLFLYTGDFFLNIRFHEDCKSKELPPSWVCLPSVHVRALGAQA
Protein: Helicase loader (Lambda P helicase loader) (Replication protein P) (P03689)
Organism: Escherichia phage lambda (Bacteriophage lambda)
Function: Replication protein P is necessary for the bidirectional replication of lambda DNA. It interacts with the ori (origin of replication) region of the genome during the initiation of replication.
Interaction partners:
Sequence:
MKNIAAQMVNFDREQMRRIANNMPEQYDEKPQVQQVAQIINGVFSQLLATFPASLANRDQNEVNEIRRQWVLAFRENGITTMEQVNAGMRVARRQNRPFLPSPGQFVAWCREEASVTAGLPNVSELVDMVYEYCRKRGLYPDAESYPWKSNAHYWLVTNLYQNMRANALTDAELRRKAADELVHMTARINRGEAIPEPVKQLPVMGGRPLNRAQALAKIAEIKAKFGLKGASV
Protein: L-threonine 3-dehydrogenase (TDH) (EC 1.1.1.103) (L-threonine dehydrogenase) (P07913)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate. To a lesser extent, also catalyzes the oxidation of D-allo-threonine and L-threonine amide, but not that of D-threonine and L-allothreonine. Cannot utilize NADP(+) instead of NAD(+).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00627}.
Interaction partners:
- 2-amino-3-ketobutyrate coenzyme A ligase
- Low specificity L-threonine aldolase
- L-threonine dehydratase biosynthetic IlvA
- L-threonine dehydratase catabolic TdcB
- Threonine synthase
- NADP-dependent 3-hydroxy acid dehydrogenase YdfG
Sequence:
MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLAAIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAAAVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMSGAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDDFQKGFDAMRSGQSGKVILSWD
Protein: Sef2p (A0A1D8PN80)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTIPVKNRLKLIIPQPPKGGRILKTCTRCRRHKTKCDAQDTNPYPCSHCFKRNLDCTLETISKTGGKITSLDVVERLSVQVTDLKEVLDNIINRRNQMVELLIQRGKSLENFDDDINSTTTSIPEPPKLDSPKVYTPPVAEIQSCISTPALSPEVFPSKADFESPASNSKFIIACNKQFKAVTLTHKQALKHFTNYENNFNHYLPIFPHEFFTSLDLVAFHKENELLFWCIMLTSLLNQKQMYHEYQCLAEHVKYLVVKKCWLNTPRSVYVISSLLILTTWPLPNYKNNIEDNISVKFISTMKSLSYQFGLHKLEFINEFSHKTKMNLSQEINSNNLIRERIYKFVNVVSNYWMINLGISNNNYNGFTQDYIINKASNIDIYKMDEFDEPDQYINCMLKISMIQSKLNENMNNLIGDSNESILLLPNQANTSKLINFNMFEIIINDLNKLKLENIDSIHKDLIDISIYYSKLQLFIYSMSYSEISFTEYQIYLSKLLKVCFQIIELIDSIPNFNLQQMPIFYKFPIELTILTLLRIFKSPVLNTVEDYKIIKNNGFAKLFKLLFKDNNWKFVNIKIWKIIEKFNQLDNMFILGNQGNSFFLIDKMKNYLVGSLNYELIWLIYKNQRNSTQTLENQQYQEPNLSFYNPHVIEYLKSNESIF
Protein: Beat IIIc (Q95UI2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
EFYRYVPRDMPPAQTFLLPGVNVDLHNSSDAIVTLRNVNLQSAGRFRCEVSGEAPSFQTVTEHGDMIVAYLPDEGSPKISGGRPRYQIGDYVRVNCT
Protein: Origin recognition complex subunit 6 (ACS-associated protein 1) (Origin recognition complex 50 kDa subunit) (P38826)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
Subcellular location: Nucleus.
Interaction partners:
- Cell division control protein 6
- Origin recognition complex subunit 4
- Origin recognition complex subunit 2
- Origin recognition complex subunit 5
- Cell division cycle protein CDT1
- Origin recognition complex subunit 1
- Origin recognition complex subunit 3
- DNA replication licensing factor MCM2
- Nucleolar complex-associated protein 3
- Meiosis induction protein kinase IME2/SME1
Sequence:
MSMQQVQHCVAEVLRLDPQEKPDWSSGYLKKLTNATSILYNTSLNKVMLKQDEEVARCHICAYIASQKMNEKHMPDLCYYIDSIPLEPKKAKHLMNLFRQSLSNSSPMKQFAWTPSPKKNKRSPVKNGGRFTSSDPKELRNQLFGTPTKVRKSQNNDSFVIPELPPMQTNESPSITRRKLAFEEDEDEDEEEPGNDGLSLKSHSNKSITGTRNVDSDEYENHESDPTSEEEPLGVQESRSGRTKQNKAVGKPQSELKTAKALRKRGRIPNSLLVKKYCKMTTEEIIRLCNDFELPREVAYKIVDEYNINASRLVCPWQLVCGLVLNCTFIVFNERRRKDPRIDHFIVSKMCSLMLTSKVDDVIECVKLVKELIIGEKWFRDLQIRYDDFDGIRYDEIIFRKLGSMLQTTNILVTDDQYNIWKKRIEMDLALTEPL
Protein: CD209f antigen (G3UVT9)
Organism: Mus musculus (Mouse)
Interaction partners:
- Lymphocyte-specific protein 1
- CD209g antigen
Sequence:
MAGEPEFHQSKNHEEEVTSGEQGFAEHDPEGLICSSKSLQGHLTQVPWLLLLLISLGLFLLMLATLVQVSRIRAYSQGQTQDQQGSSSLDKVAVPREQTHSGLEQIQQIQQQLTQFNASLAGLCRPCPWDWELFQGSCYLFSRTLGSWETSASSCEDLGAHLVIVNSVSEQRFMKYWNVRKNQRSWIGLSDHIHEGSWQWVDGSALKFSFWKEGEPNNDGDEDCVELFMDDWNDNKCTEQNFWVCEQPSAPCPHH
Protein: Aquaporin PIP2-2 (Plasma membrane intrinsic protein 2-2) (AtPIP2;2) (Plasma membrane intrinsic protein 2b) (PIP2b) (TMP2b) (P43287)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Water channel required to facilitate the transport of water across cell membrane. Plays an predominant role in root water uptake process in conditions of reduced transpiration, and in osmotic fluid transport. Its function is impaired by Hg(2+). Inhibited by cytosolic acidosis which occurs during anoxia in roots.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12566588}; Multi-pass membrane protein {ECO:0000269|PubMed:12566588}.
Interaction partners:
- PAMP-induced secreted peptide 1
- Aquaporin SIP1-1
- Probable aquaporin SIP1-2
- Aquaporin PIP2-1
- RPA-interacting protein A
- Calcium-dependent lipid-binding
- Probable aquaporin SIP2-1
- RING-type E3 ubiquitin transferase
- Probable inactive receptor kinase At5g16590
Sequence:
MAKDVEGPEGFQTRDYEDPPPTPFFDADELTKWSLYRAVIAEFVATLLFLYITVLTVIGYKIQSDTKAGGVDCGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSLIRAVLYMVAQCLGAICGVGFVKAFQSSYYDRYGGGANSLADGYNTGTGLAAEIIGTFVLVYTVFSATDPKRNARDSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSKPWDDHWIFWVGPFIGAAIAAFYHQFVLRASGSKSLGSFRSAANV
Protein: Argonaute (J9VW13)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Interaction partners:
Sequence:
MAPKLAPQGDVTSAFSKLSFGELPRGMQETLDGCPPRPGYGSSGKGITVNANMFMARFRKQGLSVNHYDIEINPVIKTKDAKKPRPLLQKIWNQMVADATGPVKEALEAAAYDQQKSFYTPHTLPMEGGKLEIIVGLVEDGIVPTDDRRRFRAVIQPAENMKIDLDTIMDYCRGDTQTEQARDTMLRAVMAMNVLFRQDPAQRFTMSGAAGRKFFTDEEGTPLSNGAVLYKGFQQSFRWTSAGFPAVQIDTAYSAFVEPGMLVDVAPKVLGLAPSGGFGGFGGRGGRGGRGGPRGGFMGAAPGPARPIQELNPAQTKRLNDILRGAKFTVTHRKTERVFSIIKLTSQPADNIKFTLNGKDGQPDRTVSVAQYFQEQYNVRVTRPRLPCVQYGKNFIPMEFVKLEPFNSIPMMRITPDQTAEIIKDAAKPPPMRQSAIAAWRQKLNYSNLPKLKAWQVEVNTNMMAVPARVLPAPSVIYEGNKTIRANFGGWNMKGVRFTKAGKPLVSWAVVSFDERCTVPDLQKFVTYFVNVLGQYNCPVQNKRPVCFQYNPNAGGPNMGIKPALQQAAKNAYMETKANPQIIFCILPKKDPSIYQAIKACAAEQLFKPVVTQCLQSLKIKSDRGIEQYCGNVAMKVHAKLGGLTHQVSHQLERTTMMVGADTGHPPAKGGALPPSIAVTVAAVNGENNRFVSGVRLQEGRVEIIQDLENMMATHIQTFEKNTGAKPLSILFFRDGVSEGQYAHCVNQELKSIKRAAARFGNYNPKVTFVICAKRHSMRFFASSDADKDRTGNLPPGTVVDSLVTSPIIHDFYLQAHAGLQGTARPTHYVVVADENKYSADKLQGLVNVLCYSYARATRSVSLVPVAYYADIVAEKAREWIYNDDSETATVPSTASGSRVEQMSFDALRISKRFESNPEFNSVAWFM
Protein: Protostome-specific GEF, isoform F (Q9W4Z0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPTMTRMHRHSSSSAVVEESRGRRRGVGVPGVGDANKENFGVHFMSSPFGNASLIALQDLSNVHGKSPQRRSFSEGSGPRQATPQLAALRCLPRTTGGAVALEDSQLSSSRMGDTTLDRMLDAIIESARKEVRCTKTLPGAGATTSTTILADNAEWSETSVHEMEVRTPTHLKRQRVVRRKNPHKTTTINQTQSHQAKKLEPLQLVPSTKRCLSFSSSSASSDLDEDEQQVAKRSSLASPTTTPPSHCTTTTSSISSSSSSNGGADMEASQRGSIDVSIAFDAKEQQLNVHVIRCRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGSMSSGYQRTAVHRHSGRPYFDQRFNFQISSGEETAGQYLQLAVWHRDRHLKRSEFLGCSTFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISIDSMGKEDPLLPQQPQQPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQATGSQSSASKANESNANHLNNGTSGGRRQSTMPNSGGSSVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWTHPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIFRRSGAGATTITSTDLGQNNVHISTRLGAAVGLGSEEHTLATTATGTTTVMSLQRTTSTRIQPLANSMSRPATACSGTTSSIEAAKRRLHLPQVTFSKESIVPVTDNRRRFLLQLISREQNFTAALHFGVDRFVQPLGERKDLISPNDHRTLFQNIDELLRIAEDILEQLCSSDQQDQEPQMNFASRVYLSKTTAICAAYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAVPRKRPDLTMFIHRPLQHFREILKLMQLLAGNCHVDTEEHKNFSTVINELQAAYREITVSSGLMEPLGEGRPLLTLQDLESRMVFTKCKPFTLAVQGRQWIFGGDLSRVEGRSVKPYWTLLFSDIIVFAKVSRDRVLFITEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAPDLTRTPKRGARRKSLILRAPSLELKAVWQNLLQRQIFLVNAALGSTPLSSPLDSPDVLNTLVPLSDIGLTTASMGSMKLPSLDSIHLKQQQKQQRTNNSHGHVHSATGVATDRTADRSHGHNHGIHGGHVEQIELLIDEKCRILNKTGTPKSSALHLANWMKGQLDKQQQQARLAAIARSQENVSAEDEQLIFNSDSEQDERITYWTRQQLEKRTKELNLAKENGGLSARPNFGGKRLSGVEELSMSATSDIYSTSEAEGVTSVISQSHSTTSDSQITVRSSPIVLDKLAVCRHCHKNCQQSGPGGARPGGGGGVNNSSSTPVLLCNSLKVQHSQSSPNRCCKLSNGIAGATEMANPKNSNRTGTGTGSVTSMSSSTITGELSSKVVASSSRRETGDTESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSLPNGHCSAGVGGGSPKPLPPPRRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGGSPAKYAACHCRCTPEDFTHAQLSPDKMEHQTCKLLESPKQTTTTLEQKQEDEQLSLMLIGLAQLAPAATLCGQERIPKEENSTPTIAVVPPTPDSVLTKTSTHVWDNSGCSSNGGGTSTTSTATTTTKQPRQAIIENIPEDSCDESPLDEEPPYRPMSSALRRFGTMSSLEKLPSDDRMDEADELDDDLDSFKPNGHDGNSPQNEEDDEDADSERALVQNDLGASSSSGVIVNGEGLASGAWTNRAGAYVSDKMSFFEESRAFIDKYLGRWNAGDAQQQHQQGTASETDEQMDECTSGATSGEEVWGTPTSGGDNDDQDLQLINSENTHSSPTKSSTSLNDDDDTELMMDELLMAPPMTASTIRGLLPRRRLEPLFEEETESDEEKTQQDSDDIKKGEATTNGHYLEDSAGSSSDSESVPPAPPLVPRPVVPDREEDPSAEGQQENLAMEDQEDLHSSVERLLPNLATSAMGPRPLLTTRLLPTTAIDPQPPAVLVASSCEYLLDQRPSSVPGRDLAGGSIGTTTMTSSRPTPLSPAKAAATPIGMNATMTTKTTTTTMMTPSRAPSSTISTISSASDTTSSGGRASGRPPRFVPPPPPPRRLLLTQTDLIAGQAKTELPRKKSGATADSGCSVAVGDAASASDPTAIGSRTMPSTPSTSSLASAVAPKRPSSTIIETCLLGAPRPASATSSATASRMAKPIRQSPPTQHQSQPRGQSCPAAVPAPSTAAPDAPTVPMPHAGCGLSPRLEMRLALNHDILGDEDLICYEPGPDLTTILGHDLSTFHRLTGRDLLSRSATNRVQPKEAVISYSQQRNSKMDTPTVNRRPRPLSAGALGGSTSNSNPNNSRSSSSHGNSPLGGGLTRAGVEPVGQQQLVVQAGGGSAGRVGGGSGSAGGNSTACSSNRGGSKLGDLEILARREKIYSMSQSRSGCRVRETTSTTTLMAMATEMRSGMDSEKRDSSWPKRAAAAASLTRTRSSTSMDGAGAISTTTTTTTTMTEEAFLETEVGRSKRLINFIKRRNSEITASSTSSTPNFSDGAIGEQPQPSHSQSSLLLQKLPPGQSQAQDSVEMAQMSPRKDNDKPSLNRRLWKQITKRRRTNSVSQIVAG
Protein: Uncharacterized protein (Q584C7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHSVNPYLSAMSFKSTDSRFEVTLPPSHCEALQGINRQEKPKTTTVPQTNHPLPLSDYAQPIVRKAGLVKASTSSVVSQFRAEGSVMEPVHALHTCIRHFLSHPEVYGSDVRAMLDRELMYVMRVKASESALLTSTTVPVSSVSLPSIANTVPENNKVGTSFLGKCSNWVVTPRSVDAAVNLDAAFGPNGMFGLGSAKLVDGSTGLFSLLERNRNLLTIQERQLPMEDGEEKGSPSTMSPLNDWEEKSVKTDGGRYREKSRVHFSVNTQSGPDVSSEYGAKLLIDGAGYEISFLRSQLHQVEAAYNAKCIRLHELQQESNRFATELESLEERNRQQNAKINELSQQVDGLTREAERWKRRANEININEKAHGGRGPTDQTRRMQASQYVELKREYTHMSQLWRETEKSLQETRRSLESAEKENRVSHRYLTDAFSFIERLERRIKRRDDFIEKLKLRQDSMEERYEKILWCLNELQTLRGQHSYVDYLLSENNVWSMFLFSRLQCRLASVGHVDEVAYDTSIPLYFRRTAAGGKLADAYSPQLVYRLITEHVQGKRRGLPVANDTFPFAVPCWRGMHSISYFSATGGNRTPNTSIMLSGELTHDRPRRSLPLLTLATVLLPPQNGAAPGEVIVDEDIPNSGQYDQLTLRYLIYCFWGERLTQYKRETERRREEYIAAREKAAALDISVDVDIESGANDMDESIKFPTFLAALVEYVRRLCPYKAPKGEEESAPKLVGPVFVRGVVLNLEGAPANPRMCLPFIFQKEENGSETPVPLSPQARELLFALYYYAEEYKDVDSDFRLFHLVAHQQLPELVAINFYASMEAMRTECDNVICESLRGTRNAPEDKTCDGAEQQCPDEATTELLFTDSPAETLRKVAVMVDEAPLAEEDTCMEADSDGEGYGVILPGAVGENEGNKEKQEAGQEPTPCYLTKLKHDILACLNRNTEKPEASATNTSVRSPKADDTTETSDALSVPKQWKRIDEKLQHMLAPFSSLLHAFKKYKERRSLGGRRCDRHKARCRLDMLPGSRSLIAIETFIAILHKHCFATYALSCSGSVRSSLLDAAMKGGHGGNDANDVGPFTRVGQLPPMNKHIRRLRFAIAMDQPSSLLRYTDLFTVDSRFGTPSHFHNEYLRLTIDTYLEQQEAYMNIILGSCVVRDGRTIPTPVVDSDGILPFPALRAGFEAVLRKLSFAPKESNIVAKHFLNYCDLLRHEDDIRQEQYVDAPLVICAEVVSKKDFARESALLREHSWSVEDEAASCSLLHLSFAARMMYIVWGLNSSSKGRLAISMLPGAARSFVNAGCTIGGQLVPSESSDSAEGLCPLREDLEPLFRFEVEEECRDALNRAKVGYGRRNELRQLLMETEDVPTTKATESSAAITDVREVEGMDPWELLVDIGCFCPLFGARLRPGTHSLHGEATSVCSRKTRTSKRVSPRPSSCDTDAPAGAIHLSGGASLLRFFGARRAAKTKGDKRKSKNRRNSQELPGAVFAQVLRSEVAPVHYQSILENLAAVSSEANASVKCVVDLANATSLLRNPHVSSPHSASLQQQTEVSNSTIPESPASRRSRAAKGRDGHASFLDGSEQRAYSPLAMSSSDKSELEGGDLAPSSLARQLHVASAVLSLL
Protein: Uncharacterized protein YDL129W (Q07555)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YIL092W
- Putative uncharacterized protein YOR200W
- Regulator of phospholipase D SRF1
- Required for respiratory growth protein 9
Sequence:
MELRSRRSAEAYLVTPEEPAKNKSERSIESNERVGTREAKSENTSVFSPAYSDTATTDSSKKVDDNEYYNFTSHFMPSLKNTRELENTILNLIQRIKEGDDETLVSEKDLILSVLNRSLASTSHWKLQAQLSELRATSEGRYAVETNLLKKEVEFLKNKTPKTNESASSAELRPLLERPLKRKLSLPGLAQRPLSTGARLEGGYGGVSPNSWKTKVPKLPLPASRPSLNLSPQKVPTGTDKVEEDTKIDTLELVENNKPHPRMRRRSDNPATNEYVRVFHLEKKEPKSRKK
Protein: Mitotic spindle organizing protein 2B (B8ZZ87)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}.
Interaction partners:
- Mitotic-spindle organizing protein 1
- Protein NEDD1
- Gamma-tubulin complex component 4
- Gamma-tubulin complex component 5
- Gamma-tubulin complex component 6
- Tubulin gamma-1 chain
- Gamma-tubulin complex component 2
- Gamma-tubulin complex component 3
- Nucleoside diphosphate kinase homolog 7
- Centrosomal P4.1-associated protein
Sequence:
MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQDPAAVSLPTSSVPETREASFLSARNSSPPARPSFSSSPQPAASPVLLHSPAATHSPLSPGPPGSLRLSCCLFSPFAGRNKGSAALGGALALAERSSREGSSQRMPRQPSATRLPKGGGPGKSPTRGST