wanglab/gogpt-training-data huggingface dataset:
Protein: GAS2-like protein 3 (Growth arrest-specific 2-like 3) (Q1L8E6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- PDZ and LIM domain protein 7
- Si:dkey-58f6.2.
- Insulin-like growth factor-binding protein 2-B
Sequence:
MMAVQAGLQAWYGEKFDVPLQSPRGPRSPRPGPGLTDVFQYDQWLAVRHEATLVPMQEDLAIWLSGMLGEQLSAERFMEELDNGVRLCRLVGILQSKIPEDSETPMPSKKIQFKKNASPGSFFARDNTANFLSWCRHIGVDETYLFESEGLVLHKEPRQVCLCLLEIGRIVSRYGIEPPVLVKLEKEIELEESMMMTDHSSPVKTFTVCCQHGAMYHADRADQDEPPCNCTQKFSIEYLSEGRYRLGDKILFIRMLHGKHVMVRVGGGWDTLKGFLLKYDPDRVLQFTTLEQKILAYQKGPSSSGSTHSSQTAQPPTMDPIAAVNLLPESSSSSSSSSTTSVYKPSTPRSVTQSPASTPLIARKAAAPKKIFNTPTSSPKTTPLSSPVPKRSPLPQSTLSGVSQKAVPKTKLRPRGSPSQPRSPVCPEPTCKQPKSSAPSAQKPPAGPVRTRIAQRRPPSPALDSKKPCSGSPRAPIPLTKPSQGKSVEQSTTASNKTTTRKPLVSSNPPVQVAAVTKPAPINTKYSTRTKASKRDEPYFEMNSKRRGKN
Protein: Meiotic driver SPOK4 (Spore killer 4) (A0A516F183)
Organism: Podospora anserina (Pleurage anserina)
Function: Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system, leading to poisoning of progeny that do not inherit the allele. Can suppress meiotic drive by the P.comata SPOK1 protein.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:B2AFA8}. Nucleus {ECO:0000250|UniProtKB:B2AFA8}.
Interaction partners:
Sequence:
MSDKDRITQLLRKLEEAKAREEEAKAREAQERCEKERLQLEHRKTTFLEYLRNCHRHLYNALRLTDTSRSSTGYTKVVGKYYPKRLRPWTNFTNVLHPRYFDLVQKICGQRQLFEPASTTKNLGTIISDHLAGNEKAIDRFEVDAVERPVQGILKVLATHEEAGKAYRCPEFRFSANLRELTQEDDRSSGADDNTSDGSLERRQQAGPNKRPTSKRKYICSNRQPDGVGIRMQPGGGQTQAFIYDYKAAHKVAIEHVRSATAKEHLFHEVVARINDDKLSRDEEVQRREQAEAFIAMALTQVFDYMITYGVSYGYVAAGRCLLLLYVDRDDWQTLYCHPCLPADDVGEPTNDWTDRLSHTAVAQLVSFCLSSFQSEALEGQSLETALSVAKATLKTWSESYADVAYLGLEPPELSSAASSQNTENSEYTSEAKPTGRKVALRSQSSCKPAAVLPQGNEHDEHDEDHSEPGASRSRLAANKRKRGPSSGGEDEDIAMADPEPTRQYCTQACLLGLKRGKDLDENCPNVSLHRFDGSSRHPVNAHRFTDMVKQQLLLSPYKGCRMVDFWDKRGAMGWLFKLELFPYGYTFVGKGTLEDRLSRLEHEGRVYARLDHLQGDVVPVHLGLVRLDRGYILPGLEFVVYMMLMSWAGQTPSASMADAETLKRESLTAIWSEGVDHGDDNRANYLWNAERCRIMIIDFDRAHLFPPLKARAVSRLSKPKRKRETPNSYLTEITGREARYVFKQMDRSPRATPSHGG
Protein: Alpha-1,4 glucan phosphorylase (EC 2.4.1.1) (E7EXT3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Phosphoglucomutase 1
- Glycogen debranching enzyme
- Glucan
- Glucan
- Glucose 1,6-bisphosphate synthase
- Phosphoglucomutase-2
- UTP--glucose-1-phosphate uridylyltransferase
- UTP--glucose-1-phosphate uridylyltransferase
- Alpha-amylase
- Alpha-amylase.
Sequence:
MSKPLTDQEKRKQISVRGLAGVENVADLKTNFNRHLHFTLVKDRNVATKRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRVYYLSLEFYMGRTLQNTMVNLALENACDEAIYQLGLDMEELQDIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVKGWQVEEADDWLRYGNPWEKARPEYMRPVHFYGRVEHHPDGVKWVDTQVVLALPYDTPVPGYRNNIVNTMRLWSAKAPCEFHLKDFNVGGYIQAVLDKNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTEIVRMDLSTLPDKVAIQLNDTHPAMAIPELMRILVDDEKLTWDVAWDITVRTCAYTNHTVLPEALERWPVDLFQNLLPRHLEIIYEINRRHMERISALYPGDFDRLRRMSLIEEGGQKKINMAHLCIVGSHAVNGVAQIHSDIIKDTVFKDFYDVDPQKFQNKTNGITPRRWLVMCNPGLAEVIAERIGEDYIRDLSQLKKLLKFVDDDALIRDIAKVKQENKMKFAVHLEEQYKVKINPNSMFDVHVKRIHEYKRQLLNCLHIITLYNRIKKEPNKAWTPRTIMIGGKAAPGYHTAKMIIKLITSIGDVVNNDIVVGDRLKVIFLENYRVTLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRVKDVEAMDKKGYDAMEYYNRIPELKQAMDQISGGYFSPADPDQFKDIVNMLMHHDRFKVFADYEDYIQCQDKVSALYKNTKEWTKMVIHNIAGCGKFSSDRTISQYAREIWGMEPSLEKIAAPDDSR
Protein: Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4) (P52798)
Organism: Homo sapiens (Human)
Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
Subcellular location: [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Interaction partners:
- Ephrin type-A receptor 4
- Ephrin type-A receptor 1
- Ephrin type-A receptor 2
- Ephrin type-A receptor 10
- Ephrin type-A receptor 3
- Ephrin type-B receptor 1
- Ephrin type-A receptor 7
- Tyrosine-protein kinase Fyn
- Ephrin type-A receptor 5
- Ephrin type-A receptor 8
Sequence:
MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPHYEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDTPSPLCLLLLLLLLILRLLRIL
Protein: Osmotically inducible family protein (Q55E30)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MSISNKIIGSAKSIWGKGGFFKGTGTVSSTSSKAFSVGLETPASAKNFILNSPNKYTDNENNTNPEELLCASHSACLAITFSSILGKHKYEATHIEADAKCTMEITPSGFVVTNIDLTLNATIPNIENEKFQELALIAKDACPISKLMNGNVKVSLKSTLNN
Protein: Zgc:162324 protein (A4IG75)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MKNEPADFTDGEIRTGPKEEIPRSCQFPCEVQHVSQLVNMKTLGQTDGKSGSSNGETEDTSGIKASITKGPTPRDSSHIAFGSKVIGPPPLTARKSSTSANTKEERFKSELSLNIPSGRSEKVQPRPPLEKPSADRTSSRRPQRIHNTKREKSCTDKEGGKISLNPEGSELQGKNAVSSLQTLGLDLTVKDKLTDPILQERVLTADDADLCDTETELSLSDEEYGEEVFTFSSCPHSARRNQASGNPVEDLTFGLKGHKLLTEGQRKDARLEDDFMGSESEEDEMHTEFLKRCAVHSITTPPPLSSIQKHTAQPKFSSEPIKTRASAVQHVSEGPKRHEPMRIAPTRCLSPSSSRQGSRLDRSEADRALPDGDTRISINRTSVREISLKNSGLQKVSVDGRVQPLGSSRCDLRSQDEEDEEDELRMLACLKREQEEEGDISSPGLSASQVHHCDISLSASSDDTSTWTQCIPLPVDQGQHYQKEMNPLLHSNPRDWMDVLSPPIVHPNQQMADGKGDHKVSTRGSKFHDNSEEEEFLNLMYDSCLNCYFDPQSGKYYELL
Protein: Actin-related protein 8 (Q9VX09)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16618800}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16618800}.
Interaction partners:
- Actin-related protein 5
- Brahma associated protein 55kD
- RuvB-like helicase 2
- Chromatin-remodeling ATPase INO80
- RuvB-like helicase 1
- LD10749p
- Actin-5C
- Polycomb protein PHO
- BcDNA.LD23876
- GEO10739p1
Sequence:
MQRSRASSTSSGRHPAPPPIGLPQPQAQPLEAPKIIVIHPGSQHLRIGRAADLNPLTLLHAVAYRRRPGASDRPHHDPLLPPLDNVNSNSGLMVEFEEQRLVVSRILQHCVVDNKNRLRVATPPQQLAHFNRSSQAEKVPAPSGQMADEPWLDREAPVLFDDRILRLGAVDARNYDIHFPIQRGELNVHNEKGGSLQASMQHLERIWSYALEERLKIPLRKLGTHCAVLVVNDVYVRRHLREFVTLLLRRLGFRRCFLVQDSVASTFGAGIGYGCVVDIGAQKTSIACIEDGISQLDARVRLSYGGGDLDQVLLLLLRKCGFPYRECNVQESYVDAHLLDELKEKFCHLNASVCGAQEKHFNLRKHNGQWLRYTIQVGDEALMAPLALFHTELLNITGRTKAVFTQQAVQDQYDCEDCFDAEYLKETGRKNGVRGGDILQLSTSAGYQPRPQLPVTADDEELIVVDQDETISNCQSQLGAQTAGGQMNSNGCYHNGQGLVLPLDQAIIQSINRLSSYETKRKMFGSILLVGSSAKLPGLAAWLEQRISQQVQSEVNVLIKGMDAGMVAWKGAAIMSVLESARELWISQNDWQRHGLRVLRERSPFLW
Protein: Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF)] (Q06186)
Organism: Mus musculus (Mouse)
Function: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Subcellular location: [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; SUBCELLULAR LOCATION: [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Epidermal growth factor receptor
- Receptor tyrosine-protein kinase erbB-4
- Pro-epidermal growth factor
- Receptor tyrosine-protein kinase erbB-3
- Proepiregulin
- CD44 antigen
- Matrix metalloproteinase-9
- Glypican-1
- Matrix metalloproteinase-14
- Matrix metalloproteinase-17
Sequence:
MKLLPSVMLKLFLAAVLSALVTGESLERLRRGLAAATSNPDPPTGSTNQLLPTGGDRAQGVQDLEGTDLNLFKVAFSSKPQGLATPSKERNGKKKKKGKGLGKKRDPCLRKYKDYCIHGECRYLQEFRTPSCKCLPGYHGHRCHGLTLPVENPLYTYDHTTVLAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDLESEEKVKLGVASSH
Protein: Tegument protein BLRF2 (P0C717)
Organism: Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Function: Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA. Acts by inhibiting CGAS-DNA phase separation: directly binds double-stranded DNA (dsDNA) in a length dependent but sequence independent manner and is able to form DNA-induced phase separation in infected cells. DNA phase separation of ORF52 mediates disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity (By similarity).
Subcellular location: Virion tegument {ECO:0000250|UniProtKB:P03197}. Host cytoplasm {ECO:0000269|PubMed:26320998}.
Interaction partners:
Sequence:
MSAPRKVRLPSVKAVDMSMEDMAARLARLESENKALKQQVLRGGACASSTSVPSAPVPPPEPLTARQREVMITQATGRLASQAMKKIEDKVRKSVDGVTTRNEMENILQNLTLRIQVSMLGAKGQPSPGEGTRPRESNDPNATRRARSRSRGREAKKVQISD
Protein: Chloride channel protein (Q8MQK2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004337}. Membrane {ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361221}.
Interaction partners:
Sequence:
LARSGHTDGSQINYSHTKSNGHTNGAGGDGDLDGTFRDHPLAQHTKLTTSLTAAGTDDEDMIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNHHNQRTMHQHVPTHSAFGDPMDGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSVLFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVLFVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLFTSSQPIQNLGPQPLKLKKILDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQMDNEDPNTVLFN
Protein: Pappalysin (A0A096MK86)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRLWSWVLRLGLLSAALGCGLAERPRRARRDPRAVRPPRPAAGPATCATRAARGRRASPPPPPGGAWEAVRVPRRRQQRAARGAEEPSPPSRALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQKSPAVITGLYDKCSYTSRDRGWVMGIHTISDQGNRDPRYFFSLKTDRARKVTTIDAHRSYLPGQWVHLAATYDGRLMKLYMNGAQVATSAEQVGGIFSPLTQKCKVLMLGGSALNHNFRGHIEHFSLWKVARTQREILSDMETRGLHTPLPQLLLQENWDNVKRTWSPMKDGHSPQVEFSNAHGFLLDTNLEPPLCGQTLCDNTEVISSYNQLPSFRQSKVVRYRVVNIYDDHHENPTVSWQQIDFQHQQLAEAFQHYNISWELDVLDINSSSLRHRLILANCDISKIGDEKCDPECNHTLTGHDGGDCRQLRYPAFMKKQQNGACDMDCNYERFNFDGGECCDPDITDVTKTCFDPDSPHRAYLDVNELKNILKLDGSTHLNIFFANSSEEELAGVATWPWDKEALMHLGGIVLNPSFYGIPGHTHTMIHEIGHSLGLYHIFRGISEIQSCSDPCMETEPSFETGDLCNDTNPAPKHKFCGDPGPGNDTCGFHGFFDTPYNNFMSYADDDCTDSFTPNQVSRMHCYLDLVYQSWQPSRKPAPVALAPQIVGHTTDSVMLEWFPPIDGHFFERELGSACDLCLEGRILVQYAFNASSPMPCGPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQGCYLELEFRYPLVPESLTIWVTFVSSDWDSSGAVNDIKLLTVSGKNISLGPQNVFCDIPLTIRLRDVSEEVYGIQIYTLDEHLEIDAAMLTSAVDSPLCLQCKPLQYKVLRDPPLLDDVGSLLHLNRRFMDMDLKLGNVYQYRIITISGNEESEPSPAAIYTHGSGYCGDGVIQKDQGEECDDMNKVNGDGCSLFCKQEVSFNCIDEPSRCYFHDGDGMCEEFEQKTSIKDCGVYTPQGFLDQWASNASVSHQDQQCPGWVVIGQPAASQVCRTKVIDLSEGISQHAWYPCTINYPYYQLPQTTFWLQTYFSQPMVAAAVIIHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCRNNPLIIPVVHDLSQPFYHSQAVHVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYSPAEQSCVHFACEATDCPELTVENASLNCSSSHRYHGAQCTVSCQTGYVLQIQRDDELIKSQVGPSVTVTCTEGKWNKQVACEPVDCGIPDHHHVYAASFSCPEGTTFGRRCSFQCRHPAQLKGNNSFLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSLCKYKCKPGYHVPGSSRKSKKRAFKTQCTQDGSWQEGTCVPVTCDPPPPKFHGLYQCTNGFQFNSECRIKCEDSDASQGRGSNTIHCRKDGTWSGSFHVCREMQGQCSAPNQLNSHLKLQCPDGYAIGSECATSCLDHNSESIILPVNLTVRDIPHWMNPTRVQRIVCTAGLQWYPHPARIHCVKGCESERKKDRKKGRKKAKEEEEEEEEEEEEEEEEEEEEKREREHCFNFHTTANKIYFSASSYSSKEKYGT
Protein: Chromatin modification-related protein EAF1 A (ESA1-associated factor 1 A) (F4J7T3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.
Subcellular location: Nucleus {ECO:0000269|Ref.3}.
Interaction partners:
- SWR1-complex protein 4
- Phosphotransferases/inositol or phosphatidylinositol kinase
- Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein
- Transcription initiation factor TFIID subunit 14
- Enhancer of polycomb-like protein
- Transcription initiation factor TFIID subunit 14b
- Enhancer of polycomb-like protein
- Histone acetyltransferase of the MYST family 1
- Actin-related protein 4
- Chromatin modification-related protein EAF1 B
Sequence:
MHGSVSGYLLVNAEVDSMGGVIDSGGGIGVKTSPRRTAIEKAQAELRQEYDVREERRRELEFLEKGGNPLDFKFGIATSHSVQSTSLTDQQAEHFVNSEVKDSFALTASPHGDSVESSGRPGVPTISEPNTADNLLLFDSENKSVEGERNLRHPNRQNRTSESERSSKAHTNQNTKETEDSAIFRPYARRNRSKISRDPARSSSTDLVQNRGGLATSISIRRGSVEGKGCIPEAANQKDMHTTSVSCPVFANSNGNIVPKNRVSSNSLNTKVDGEPVVRESTAGSKTSLLKDEADISYSKSSAYLPVGESGLAGEKAQLVSTGGSPKAATIAGQKNSSTQLNGLRDSTVEEESLTNRGATGTNGLESESSHANNVEVNVDNERDLYKVDKLDSDEISMQKTLRVEGLLDQTVGEMTKTKIEDETGQSTTIISECIPECEMQMKSVKIENQSHRSTAEMQTKEKSSETEKRLQDGLVVLENDSKVGSILSENPSSTLCSGIPQASVDTSSCTVGNSLLSGTDIEALKHQPSSDAVMLDTVKEDAILEEARIIQAKKKRIAELSCGTAPVEVREKSQWDFVLEEMAWLANDFAQERLWKMTAAAQICHRVALTCQLRFEERNQHRKLKKIASVLSNAILQFWSSVEAEVPGELEETSLGIVKETCQESNCLNGRRCLAAGVKEYASRFLKYNNSSISYHSAAPSTPDNMCDPEILDISMVDQLTEASLFYSVPSGAMEVYLKSIESHLTRCEKSGSSMQEEVDTSAYDTAGDIGYNVTAFDEDEGETSTYYLPGAFESSRSFNISHKKRKNLMKSHSARSYDLGDDLPYVNNTGGSNSSSLMAKRPDSNINAGSVPTRRVRTASRQRVVSPFGCATTGNLPVPSKTDASSGDTSSFQDEYSSLHGGSAVQKGTEVESSVNFEKLLPYDMAETSGRPKKKKKTHQGSAYDQTWHLDPSVHVEQKDHWKKRPENNFDMNGLYGPHSAKKQKTTKQLVENNFDMAIPHTGSIPSPAASQMSNMSNPNKSIKFIGGRDRGRKIKGLKISPGQHGSGNPWSLFEDQALVVLVHDMGPNWELISDAMNSTLKIKCIYRNPTECKDRHKILMDKTAGDGADSAEDSGNSQSYPSTLPGIPKGSARQLFQRLQGPMEEDTLKSHFEKICLIGKKLHYRKTQSVIGVSVVSFVHGIQFSSCTGAGISQSLDIPGLHVSKYSCKSWLGFPENDGRDSKQIVPVHNSQVMALSQVFPNNLNGGVLTPLDVCDASTSGQDVFSLENPGLPMLNQGTPVLPTSGAHPSTPGSSGVVLSNNLPTTSGLQSASVRDGRFNVPRGSLPLDEQHRLQQFNQTLSGRNLQQPSLSTPAAVSGSDRGHRMVPGGNAMGVSGMNRNTPMSRPGFQGMASSAMPNTGSMLSSGMVEIPNTGNIHSGGGASQGNSMIRPREAVQHMMRMQAAQGNSPGIPAFSNLSSGFTNQTTPVQAYPGHLSQQHQMSPQSHVLGNSHHPHLQSPSQATGAQQEAFAIRQRQIHQRYLQQQQQQQQFPASGSMMPHVQQPQGSSVSSSPQNSPQTQPPVSPQPLSMPPVSPSPNINAMAQQKPQKSQLALHGLGRSPQSGTSGVNNQAGKQRQRQLQQSARQHPHQRQPTQGQQLNKQLKGMGRGNMIHQNITVDQSHLNGLTMPQGNQATEKGEIAVPVRPDQQSSVGTTTSTNLQSKPFVSPLSSNHSQQLPKSFPGALPPSPQQQMQLHSDNSIQGQSSPATPCNILSTSSPSIAPAVAPSNHQHLLIHQKQRNQVQSTAQRVVQHNHLGNSELSKKSQAERMPRVPQSVTNTTQTVSMGTTKGMPQASNDLKNIKAVGSTAVPALEPPSCVASVQITASKVVNSSNTDSAGNDPVSTPNQGLAQKHGIKGVTQRQQQSLPSEEKRPKLPEKPTVQNQKHLASEEQPHLEEAQELSSSKPPDTKVE
Protein: LD39664p (Q960Q9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTTMSPPSPMDALCRVCHTASPRCLPLFKPLDDPISGKPATLASILSYCSGLEILEAELFLPHHICPDCVAKLRLSLEFKRSVHRMDRILRQSHADFCRSKKISAVNTRARLSTEIPEDFVLVLDDQEVTEYPAETIRDEEQLLVVESDEAESRLEAPIVQEERLDIALEQHEDDLCEIVDDPDPEQRRSRLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKIRQEDNDHCIEECLQVEPVLQAKAGEDVYEIVEKSAQTSATQKTLPSGSRPWKPLNPSLQCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSHKAGRQRRRAEHEVGVQLEEQDENVET
Protein: CEA cell adhesion molecule 1 (CEA-related cell adhesion molecule 1, isoform 1/2L) (Q3LFS9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MELASAHLHKGQVPWGGLLLTASLLASWSPATTAEVTIEAVPPQVAEDNNVLLLVHNLPLALGAFAWYKGNTTAIDKEIARFVPNSNMNFTGQAYSGREIIYSNGSLLFQMITMKDMGVYTLDMTDENYRRTQATVRFHVHQPVTQPFLQVTNTTVKELDSVTLTCLSNDIGANIQWLFNSQSLQLTERMTLSQNNSILRIDPIKREDAGEYQCEISNPVSVRRSNSIKLDIIFDPTQGGLSDGAIAGIVIGVVAGVALIAGLAYFLYSRKSGGGSDQRDLTEHKPSASNHNLAPSDNSPNKVDDVAYTVLNFNSQQPNRPTSAPSSPRATETVYSEVKKK
Protein: Ectodysplasin (B0YIF1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLIDLHAAMEPKREPAKLEERERTQAACECQSQCNNCKIFLSLFILSLSLHLVTLFCYLDLRSELKREISQKNKDEVSSTGPVPHYEATEPVLQSPDTDHPTIGDQSRWRDEHTRGLERVIHRTKRSETNGKKKGERKKGKKGPPGAPGPPGPPGPQGPPGIPGIPGIPGSNAMGPSGPPGPPGPQGPPGPQGPPGPQGPSGGEKGKHREAQPAVVHLQGQETTIQVKEDLSEGVLKNWRMISIHQRVFKMHSRSGELEVLLDGTYFIYSQVEVYYLNFTDIASYEVMVDKTPFLRCTRSIETGQRKFNTCYTAGVCLLRARQRISIRMVYEDTSISMSNHTTFLGSIRLGDAPSAGHT
Protein: Protein STPG4 (Gonad-specific expression gene protein) (GSE) (Sperm-tail PG-rich repeat-containing protein 4) (Q9DAG5)
Organism: Mus musculus (Mouse)
Function: Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16571911}. Nucleus {ECO:0000269|PubMed:16571911, ECO:0000269|PubMed:23560077}. Note=Localizes in female and male zygote pronucleus (PubMed:16571911, PubMed:23560077). Associates preferentially with the paternal chromatin during zygote development (PubMed:23560077). {ECO:0000269|PubMed:23560077}.
Interaction partners:
Sequence:
MAEPTVVIAPTTVPREDLGHGEPLLMTAKQVKKTPGLEREGWWRLTITDTPIPGTYHFRTFTEEALLNPVKITYNFKNEGRKKLPLVLRNDPVPTDLPQYSPPDFLELLKKQTASYSFKDKPRADPSTLVDKDESLHLCPGQYEVLPAPVPKSPARSFVFRSSVQRFPPNYFTPHEGPGPGDYELKASPKGSITSCFRSKVPRFLPVSSKTPGPGAYTSSRQFPKQSSTIAKMGREHSLFFNNTIGF
Protein: Protein Tob1 (Transducer of erbB-2 1) (Q61471)
Organism: Mus musculus (Mouse)
Function: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15235587}. Nucleus {ECO:0000269|PubMed:15235587}. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.
Interaction partners:
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 8
- Cytoplasmic polyadenylation element-binding protein 3
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex subunit 2
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 6-like
- CCR4-NOT transcription complex subunit 6
- CCR4-NOT transcription complex subunit 11
Sequence:
MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHVGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDSSETGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSSKVARTSPINLGLTVNVNDLLKQKAISSSVHSLYGLGLGSQQQPQPQPQQQQQQQPSSSQPPPPLPQQQQQQPQQQQQQQQQTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN
Protein: Chromodomain helicase DNA binding protein 8 (A0A2R8Y808)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKGRGGESQYPPSPSLPRPWRSTLHYFPKMADPIMDLFDDPNLFGLDSLTDDSFNQVTQDPIEEALGLPSSLDSLDQMNQDGGGGDVGNSSASELVPPPEETAPTELSKESTAPAPESITLHDYTTQPASQEQPAQPVLQTSTPTSGLLQVSKSQEILSQGNPFMGVSATAVSSSSAGGQPPQSAPKIVILKAPPSSSVTGAHVAQIQAQGITSTAQPLVAGTANGGKVTFTKVLTGTPLRPGVSIVSGNTVLAAKVPGNQAAVQRIVQPSRPVKQLVLQPVKGSAPAGNPGATGPPLKPAVTLTSTPTQGESKRITLVLQQPQSGGPQGHRHVVLGSLPGKIVLQGNQLAALTQAKNAQGQPAKVVTIQLQVQQPQQKIQIVPQPPSSQPQPQQPPSTQPVTLSSVQQAQIMGPGQSPGQRLSVPVKVVLQPQAGSSQGASSGLSVVKVLSASEVAALSSPASSAPHSGGKTGMEENRRLEHQKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVRPEEEGEKKRRKKSAGERLKEEKPKKSKTSGASKTKGKSKLNTITPVVGKKRKRNTSSDNSDVEV
Protein: Mitotic spindle assembly checkpoint protein MAD2A (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1) (Q9Z1B5)
Organism: Mus musculus (Mouse)
Function: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (By similarity). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, and recruits an open conformation of MAD2L1 (O-MAD2) which then promotes the conversion of O-MAD2 to C-MAD2 (By similarity). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13257}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm {ECO:0000250|UniProtKB:Q13257}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Recruited by MAD1L1 to unattached kinetochores (By similarity). Recruited to the nuclear pore complex by TPR during interphase (By similarity). Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2 (By similarity). {ECO:0000250}.
Interaction partners:
- Mitotic spindle assembly checkpoint protein MAD1
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Cell division cycle protein 20 homolog
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Mitotic checkpoint protein BUB3
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 10
- Cell division cycle protein 16 homolog
- Serine/threonine-protein kinase Nek2
Sequence:
MAQQLAREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLTTTDPELIKYLNNVVEQLKEWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKEEGVRREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNCEEVRLRSFTTTIHKVNSMVAYKTPVND
Protein: Protein maph-9 (Q18452)
Organism: Caenorhabditis elegans
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:27930654}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:27930654}. Note=Localizes to the base of the cilium. {ECO:0000269|PubMed:27930654}.
Interaction partners:
- Protein rpi-1
- Protein KATNIP homolog
- Protein fam-161
- Doublecortin domain-containing protein
- Doublecortin domain-containing protein
- WD Repeat protein
- Cilia- and flagella-associated protein 36
- Echinoderm microtubule-associated protein-like elp-1
- F59G1.4
Sequence:
MGEYQLHQSRNLSVNQTLDEILGISRKSETTTTSSGSSGAEKNALNSPIRPPTRHGRESSGSNEENKDPIQLENGNGSTLSFLTSSSSATSSTAARRNSDDDFIKKLNDIRRRSLISTMDATSTPTTSVPIHFDSPRRESRPCLEIHVEESPEELSTHAVEITEFHRDLSENSLGTSTDHEDPSLTFRVDKELEQSESKKTTKRPASGVKKTLKASISIDAPKPKPRPRPQTSANLSTKTIKDKDQEMMQMSMFGSKLNKPSDAHHKEWLQKKEREIREKKAKEKAAAEQKAATEKERRENSAKLYQRWVQDHDKKAKELKSKKTQQERKKSENEKTTQDQKLKEAEKNYEMWKRERSKSVTDIRKKLEQEEDKKRKKEEEAKNEKIKEAQAAFLAWKRKKEELLNEEAEKLKKEQVQKQLEESEKMTRLSLANEAYETWIELKESEREFIADFVLIEAPPIPWLPPSNLIPRQFVRSSNGNRLRARSQSAKSIAKRSRSRPGTTTSLRPFR
Protein: Uncharacterized protein (Q9FG25)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKLRQNPSRFTSVLKWVSQLSLETQLKPSISGTGFLLRCAQTPRSFATVTGNEVCSEKSKVKRTRNGFKITPNVRKLAEEAMLDYFYSTRGLQYMVAESMSKNSPIFIDNLLKKVDCVTASDINQSITRYLRFHPVNEFEPFLESSGLNPSEYNHLVPCDKVFLDEEGFLLENHHVLCYSGVDPKRIGKIFKEAREVFSYETGVLASKIKAYEDLGFSRLFLSKLIVCSPRVLMGHTNIELVQVVKTLQSLGFEFEWVMENLSDEGPDWSSVHRVLSLLREICFDEEKLYGLIRNCPSLLFENSGKWTGILVGFETKLGASRSELCSLFQKFPLIQVEKCVSNLRQCFLFLKEIEMEDDEIHKVFRSHSWWLGSCKLKKTSSLLVFLKAGKTRVCQVIQENPEEMKKWTMGSKIQPLPATNVDIESKSMKTQFLLDLGYKENSEEMETAMKNFRGKGSELRERFNVLVSLGFTKKDVKDMVKACPTMLSQTCDILESKVNYLIKELGYPLSTLVDFPSCLKFTLQRMKLRFAMFSWLQARGKVDRKIKVSTMLACSDKIFVMSFMRNPRFKSLLLNWVSQAFAETPLKPQLSRNPRFFATQRALVDAEVSGEKWGLRTRNEIRKVAQVAMFDYFYQTRGLQFLVAESMSKNAPVFNDNLLKKLNGCDVDVDDDDDIVKAITRFLWFHPVNEFEPFLESLGLKPSEFSHLIPCDKMFLNEDAFLLENYHVFWNYGIGREKMGKIFKEAREVFGYETGVLASKIKSYEDLGFSKLFLSKLIVCSPSILIGDMNVGLAKVMEMLKAIGFGVDWVTENLSEEVSYDWSSMHRCLSFLRDLYVDENELCELIRKMPRLIFEDSGEWTLILAGFEAKLGSSRSELSSLFQKFPQCQSLGKFVLNLRHCFLFLKDIEMDDDEIGKIFRLHSLWIGVSRLKQTSTLLINLKGGKGRLCQVIQENPEEMKKWIMGLRVQPLPATGYKVNTKSKTMKTQFLLDLGYKENSEEMERALKNFRGKGSELRERFNVLVSFGLTEKDVKDMVKACPSILTQACDILESKVNYLVKELGYPLSTLVTFPTCLKYTLQRMKLRFSMFSWLQDRGKADPKLQVSTILVCSDKFFATRFVNRHPDGPKHLEDLKKLLVC