wanglab/gogpt-training-data huggingface dataset:
Protein: Probable serine/threonine-protein kinase zyg-1 (EC 2.7.11.1) (Zygote defective protein 1) (Q9GT24)
Organism: Caenorhabditis elegans
Function: Protein kinase that plays a central role in centrosome duplication, control of centrosome size, spindle formation and nuclear envelope breakdown during cell divisions. Paternal copy is required to regulate synthesis of daughter centrioles prior to fertilization. Maternal copy regulates centrosome duplication during later cell cycles. Functions upstream of sas-5 and sas-6, and is required for their localization to the centrosome. Its role in nuclear envelope breakdown is mediated by the spindly-like protein spdl-1 and the RZZ complex, which in turn recruits the spindle checkpoint proteins mdf-1 and mdf-2, dynein and dynactin to unattached kinetochores.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11371350, ECO:0000269|PubMed:19081077, ECO:0000269|PubMed:22623721, ECO:0000269|PubMed:27689799}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:11371350, ECO:0000269|PubMed:19081077}. Note=Component of the centrosome (PubMed:11371350). Present at centrioles only immediately before their duplication (PubMed:11371350). Expression at centrosomes increases from prophase to anaphase during mitosis (PubMed:22623721).
Interaction partners:
- Spindle assembly abnormal protein 5
- Spindle assembly abnormal protein 4
- Spindle-defective protein 2
- Spindle assembly abnormal protein 6
- Suppressor of zyg-1 protein 20
- Spindle assembly abnormal protein 7
- Spindle-defective protein 5
- Tubulin gamma chain
- MAD related
Sequence:
MSGGKSGSRLSAYSHLKEIGKGGFGVVYAAQRENGEKVAIKRIDKKVPKNRVWTEIQTMKELKKSKYVVEFYEDFVEDGYTYIVMELCEGGSLQAYVREHGALDDATAVHVLRQLISAVSFMHRVNVIHRDLSAGNVFIKDSKKKKMTVKLGDFGLATTLGRGETTCTIVGTPGFIAPQVYDQEYTQSADVYSLGAVLYTMLTARNPPPKGLPPTCGMSPNAARLVEQMMDTDAKKRIPLTQIVLSEFMYENTNENAVIFSREHSRDGRRQRSREPVRSSRDDRSRDGRALIRSSSQPAHSGRAPLSNRPIHDRMPSTSSRGFDSERGRERDRDSGRGTVPPSREDRNRSQLWPIRMDRLEGQRVCTAGGRYIVELDTRCRFEVAAQGNFVKRILIVEVDEMVQTVYVHRIPDRTVRGRNGEEELITLTNNPFVYTSYSQMPKEVQNDYMRLQKMVAVTISGRVAKVTFRRPSQFPDAQAQLMENGDLRIKLPRSVIVRKMDNGEIFNCIDGIATQKQAVSGITLTKVNEVYKYLIRFEQCLNGMDRGMVCFPIVFSAGTNMVGSSPSSLMPSGSSQTSRFPFSNLSNNQPSLVPHSAPFLTKPTSSQRASSANVQRRVSTDENSSPSVAPSKYKIKIDPTTQKVRSIQATDGRVLRCSTSKADQFIFTDPAIRPDDQRFMRTDRVPDRASEMLHTLCERMRKLHQ
Protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Scavenger receptor cysteine-rich domain-containing protein LOC284297 homolog) (Q8BV57)
Organism: Mus musculus (Mouse)
Function: Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.
Subcellular location: Secreted {ECO:0000269|PubMed:21217009}. Cytoplasm {ECO:0000269|PubMed:21217009}.
Interaction partners:
Sequence:
MRGLACLLAMLVGIQAIERLRLADGPHGCAGRLEVWHSGRWGTVCDDGWDLRDAEVACRVLGCGGALAAPGGAFFGEGTGPVWLSELNCRGNEGQLGICPHRGWKAHICSHEEDAGVVCVGQRAANSREDSMSLLDGDPWLALSGELSPSSEEPPITHAPQPAASSQNGPRKKNPRPPKQTKSTRAPVLTNGAPHQERLRLVSGPHGCAGRLEVWHGGRWGTVCDDGWDLRDAAVACRELGCGGALAAPGGARFGPGEGPVWMDDVGCGGGEEALRDCPRSPWGRSNCDHTEDAGLVCTGPAPRIRLADGPHGCAGRLEVWHGGRWGSVCDDAWDLRDAAVACKELGCGGALAAPGGAFFGEGTGPIILDDLRCRGNETALRFCPARPWGQHDCHHREDAGAVCDGMPLGAVQPTVPAVDSNSTAHRLLSTSVGQMPGPAGPWPPSASPTAPPEPGPEAGSPQLRLVAGPSRCSGRLEVWHDGRWGTVCDDSWDMRDSAVVCRELGCGRPRQPDPAAGRFGWGAGPIWLDDVGCMGTEASLSECPAASWGKHNCAHNEDVGVTCTGTPGLDTISDPFSWSWLPGLGRDQDAWLPGELTTKPSASLTSSVPQKPTKVPGKAPKSTKKWVTKNARRPTTQPPGMPTTKHSRAPGTPTSLHPTARTSELPKRLTTEAPHRQTSHTTVRLTPRVPWEWTSEPVVSQSTQGPQEVTSEATTTENPQTSLEPSGENTEGSLESSQDPATTPTAGVPVPSGPFRVRLADGPNRCAGRLEVWHAGLWGTVCDDSWDIRDATVACWELGCGKVRPRVGKTHYGPGTGPIWLDDMGCKGSEMSLSDCPSGAWGKHNCDHEEDVVLTCTGYTGDDDYPSWTWDPTSGEDLTKGTTVAARPGHTLSWATTTNTEVPSPATQNLPDTDDQGGYESSWTWDTPSGRGLFKGTPTTTKPGSTVTTSTSKSPGHPFPAPRARAGSPRKPTPERRPLPTSATTSSPASSSSPEPSGSRQTSGSWPQLIPDSKQEGTSSSPKPSLLTPGLPSPATFALSTPNTSLLPTRSPELSGSPTPTSPEGLTSASSMLSEVSRLSPTSELTPGPDTTPAPEIIPESSDSSDLPMNTRTPTQPFTASHPTSIPQLNTTSYPTIAPQPTTNPQQPRSPHPATSPQPPTNTHPSSTPATPTESLPSSRKTELSSPTKPRLNSELTFEEAPSTDASQTQNLELFLASESGPSSPSPASNLDPLPTDAFKPPRSQTLHSASDHLTQGPTPNHNPDPFGPCVSPLPPVRVMACEPPALVELVGAVREVGDQLQRLTWVLEQDRQERQVLALGLAQLVEAAQGLGQLSETVKRLAEVAWPPSTPVPMTTTTEEEERPLRGDV
Protein: At3g49930 (C2H2 and C2HC zinc fingers superfamily protein) (Zinc-finger-like protein) (Q9SN24)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- B3 domain-containing protein At5g18090
- AT4g05070 protein
- Transmembrane protein
- At3g13845
- At1g67860/T23K23_29
- Small polypeptide DEVIL 6
- Protein RALF-like 24
- Succinate dehydrogenase assembly factor 4
- Secreted transmembrane peptide 5
- Transmembrane protein
Sequence:
MALDTLNSPTSTTTTTAPPPFLRCLDETEPENLESWTKRKRTKRHRIDQPNPPPSEEEYLALCLLMLARGSSDHHSPPSDHHSLSPLSDHQKDYKCSVCGKSFPSYQALGGHKTSHRKPVSVDVNNSNGTVTNNGNISNGLVGQSGKTHNCSICFKSFPSGQALGGHKRCHYDGGNGNSNGDNSHKFDLNLPADQVSDETIGKSQLSGEETKSVL
Protein: Solute carrier organic anion transporter family member 74D (Ecdysone Importer) (EcI) (Organic anion transporting polypeptide 74D) (Q9VVH9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transporter that mediates the cellular uptake of ecdysteroids, including ecdysone, from the hemolymph.
Subcellular location: Cell membrane {ECO:0000255|RuleBase:RU362056, ECO:0000269|PubMed:30293839}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU362056, ECO:0000269|PubMed:30293839}.
Interaction partners:
Sequence:
MTKSNGDVEAAAQVQSLGGKPSNGHGQLNGNGYHQNGGRRDSSQAFTPLLSQHNNGTTNGEVTTPPPSTVLYESTPSNNNEWKAPEDLGHLKNGLGNILSSNNNGTGNGHSLSEKYAHEQAPLTGGYKLPPRSSESEESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPVEPEEKPKLKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGNSPALIEPTCSAALNCTCDKENFAPICADGKMYISACHAGCSSSSLRPSDNRTLYSDCACIPDAPEAVNGYCDNNCKNFIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQYFLGITAGIMFLAFLMDLVVWRKAHRIDIAPEDPQEGGPASNGRTLEVSESKQPITPAPDTTV
Protein: tRNase Z TRZ1 (EC 3.1.26.11) (Nuclear ribonuclease Z) (Nuclear RNase Z) (Short tRNase Z 1) (Zinc phosphodiesterase NUZ) (tRNA 3 endonuclease) (tRNase ZS1) (AthTRZS1) (Q8LGU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Zinc phosphodiesterase, which displays tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Can use bis-(p-nitophenyl) phosphate (bpNPP) as substrate. Involved in the processing of small nucleolar RNAs (snoRNAs).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19411372}.
Interaction partners:
- tRNAse Z TRZ4, mitochondrial
- tRNase Z TRZ3, mitochondrial
- tRNase Z TRZ2, chloroplastic
- DExH-box ATP-dependent RNA helicase DExH16, mitochondrial
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Dynamin
Sequence:
MEKKKAMQIEGYPIEGLSIGGHETCIIFPSLRIAFDIGRCPHRAISQDFLFISHSHMDHIGGLPMYVATRGLYKMKPPTIIVPASIKETVESLFEVHRKLDSSELKHNLVGLDIGEEFIIRKDLKVKAFKTFHVIQSQGYVVYSTKYKLKKEYIGLSGNEIKNLKVSGVEITDSIITPEVAFTGDTTSDFVVDETNADALKAKVLVMESTFLDDSVSVEHARDYGHIHISEIVNHAEKFENKAILLIHFSARYTVKEIEDAVSALPPPLEGRVFALTQGF
Protein: Proteasome subunit beta (H0YKT8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU004203}. Nucleus {ECO:0000256|RuleBase:RU004203}.
Interaction partners:
Sequence:
MEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSK
Protein: DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58) (Q27968)
Organism: Bos taurus (Bovine)
Function: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250}.
Interaction partners:
- Interferon-induced, double-stranded RNA-activated protein kinase
- Endoplasmic reticulum chaperone BiP
- Endoplasmin
- DnaJ homolog subfamily B member 1
- Protein disulfide-isomerase A6
- X-box-binding protein 1
- alpha-1,2-Mannosidase
- Hypoxia up-regulated protein 1
- Endoplasmic reticulum resident protein 44
- Activating transcription factor 6
Sequence:
MVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIELKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLVKSDEMQRLRSQALDAFESSDFTAAITFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKASSKLKNDNTEAFYKISTLYYELGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIKEGRYTDAISKYESVMKTEPGVHEYTIRSKERICHCFSKDEKPVEAIRVCSEVLQVEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQRRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFSPFSSGGPFRFKFHFN
Protein: RH01747p (Snustorr snarlik, isoform A) (Snustorr snarlik, isoform B) (Snustorr snarlik, isoform C) (Snustorr snarlik, isoform D) (Q9VR45)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Oskyddad, isoform A
- RE40518p
Sequence:
MMSWPKQWGFASLWLPVLIGLLHTQNASAFIVPRELPSILSIVYSNIPPIKKGTDSRLGFGFRLGEHADFQVMVELGPQKETRPIGEPNQDDQSFNKRQVSQSDQKALARQLYRQQVMEEAERLMTSTERNGASWLQAWSNGMKPQKPKSKDQAKKPVKESSSSNYQNAQATDPTSAMKQLQLLYKMATSSSTTTTTTVPPVFTGGSLNLGGPSGFKLPPPALSQDTNTLSNPDPLKSKSEITKELMDVSLETDT
Protein: [Val1,Thr6]-bradykinin [Cleaved into: Des-Arg9-[Val1,Thr6]-bradykinin] (C0HKA9)
Organism: Physalaemus nattereri (Cuyaba dwarf frog) (Eupemphix nattereri)
Function: Induces contraction of rat ileum smooth muscle but has no activity towards rat smooth muscle from tail artery, urinary bladder or uterus. Binds to both bradykinin receptor B1 (BDKRB1) and B2 (BDKRB2); the effect via BDKRB1 is stronger.
Subcellular location: Secreted {ECO:0000269|PubMed:26443407}.
Interaction partners:
Sequence:
VPPGFTPFR
Protein: Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (Hepatic lectin 2) (HL-2) (mHL-2) (P24721)
Organism: Mus musculus (Mouse)
Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- Asialoglycoprotein receptor 1
- Thyroglobulin
Sequence:
MEKDCQDIQQLDSEENDHQLSGDDEHGSHVQDPRIENPHWKGQPLSRPFPQRLCSTFRLSLLALAFNILLLVVICVVSSQSIQLQEEFRTLKETFSNFSSSTLMEFGALDTLGGSTNAILTSWLAQLEEKQQQLKADHSTLLFHLKHFPMDLRTLTCQLAYFQSNGTECCPVNWVEFGGSCYWFSRDGLTWAEADQYCQLENAHLLVINSREEQDFVVKHRSQFHIWIGLTDRDGSWKWVDGTDYRSNYRNWAFTQPDNWQGHEQGGGEDCAEILSDGHWNDNFCQQVNRWVCEKRRNITH
Protein: Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Protein SALT OVERLY SENSITIVE 1) (Q9LKW9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in electroneutral exchange of protons for cations such as Na(+) or Li(+) across plasma membrane. Involved in Na(+) and K(+) homeostasis. Required for cytoplasmic Na(+) and Li(+) detoxification by secreting them from the cytoplasm to the extracellular space. Regulates Na(+) content of the xylem sap.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11884687, ECO:0000269|PubMed:12805632}; Multi-pass membrane protein {ECO:0000269|PubMed:11884687, ECO:0000269|PubMed:12805632}.
Interaction partners:
- CBL-interacting serine/threonine-protein kinase 24
- Calcineurin B-like protein 4
- Sodium transporter HKT1
- Inactive poly [ADP-ribose] polymerase RCD1
- Calcineurin B-like protein 10
- Potassium channel AKT1
- Delta-1-pyrroline-5-carboxylate synthase A
- Calcineurin B-like protein 1
- Pyrophosphate-energized vacuolar membrane proton pump 1
- Pyridoxal kinase
Sequence:
MTTVIDATMAYRFLEEATDSSSSSSSSKLESSPVDAVLFVGMSLVLGIASRHLLRGTRVPYTVALLVIGIALGSLEYGAKHNLGKIGHGIRIWNEIDPELLLAVFLPALLFESSFSMEVHQIKRCLGQMVLLAVPGVLISTACLGSLVKVTFPYEWDWKTSLLLGGLLSATDPVAVVALLKELGASKKLSTIIEGESLMNDGTAIVVFQLFLKMAMGQNSDWSSIIKFLLKVALGAVGIGLAFGIASVIWLKFIFNDTVIEITLTIAVSYFAYYTAQEWAGASGVLTVMTLGMFYAAFARTAFKGDSQKSLHHFWEMVAYIANTLIFILSGVVIAEGILDSDKIAYQGNSWRFLFLLYVYIQLSRVVVVGVLYPLLCRFGYGLDWKESIILVWSGLRGAVALALSLSVKQSSGNSHISKETGTLFLFFTGGIVFLTLIVNGSTTQFVLRLLRMDILPAPKKRILEYTKYEMLNKALRAFQDLGDDEELGPADWPTVESYISSLKGSEGELVHHPHNGSKIGSLDPKSLKDIRMRFLNGVQATYWEMLDEGRISEVTANILMQSVDEALDQVSTTLCDWRGLKPHVNFPNYYNFLHSKVVPRKLVTYFAVERLESACYISAAFLRAHTIARQQLYDFLGESNIGSIVINESEKEGEEAKKFLEKVRSSFPQVLRVVKTKQVTYSVLNHLLGYIENLEKVGLLEEKEIAHLHDAVQTGLKKLLRNPPIVKLPKLSDMITSHPLSVALPPAFCEPLKHSKKEPMKLRGVTLYKEGSKPTGVWLIFDGIVKWKSKILSNNHSLHPTFSHGSTLGLYEVLTGKPYLCDLITDSMVLCFFIDSEKILSLQSDSTIDDFLWQESALVLLKLLRPQIFESVAMQELRALVSTESSKLTTYVTGESIEIDCNSIGLLLEGFVKPVGIKEELISSPAALSPSNGNQSFHNSSEASGIMRVSFSQQATQYIVETRARAIIFNIGAFGADRTLHRRPSSLTPPRSSSSDQLQRSFRKEHRGLMSWPENIYAKQQQEINKTTLSLSERAMQLSIFGSMVNVYRRSVSFGGIYNNKLQDNLLYKKLPLNPAQGLVSAKSESSIVTKKQLETRKHACQLPLKGESSTRQNTMVESSDEEDEDEGIVVRIDSPSKIVFRNDL
Protein: Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3) (P02656)
Organism: Homo sapiens (Human)
Function: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
Subcellular location: Secreted {ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}.
Interaction partners:
- Apolipoprotein C-I
- Apolipoprotein C-II
- Apolipoprotein E
- Apolipoprotein B-100
- Apolipoprotein A-II
- Apolipoprotein A-IV
- Apolipoprotein A-I
- Apolipoprotein A-V
- Beta-2-glycoprotein 1
- Lipoprotein lipase
Sequence:
MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA
Protein: Large ribosomal subunit protein eL27 (60S ribosomal protein L27) (P61353)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:A1XQU5}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:A1XQU5, ECO:0000269|PubMed:25957688}.
Interaction partners:
- Small ribosomal subunit protein eS24
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein eS10
Sequence:
MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF
Protein: Zwei Ig domain protein zig-5 (2 Ig domain protein zig-5) (Q9XXD7)
Organism: Caenorhabditis elegans
Function: Together with zig-8, required postembryonically to maintain the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP and HSN neurons by preventing their displacement that could occur during body growth and movement. May act by reducing L1CAM-like protein sax-7 (long isoform) adhesion.
Subcellular location: Secreted {ECO:0000255}.
Interaction partners:
- Zwei Ig domain protein zig-8
- Zwei Ig domain protein zig-7
- Potassium channel domain-containing protein
Sequence:
MPSPLNHHLSCFVLSVILLGSHVSTSKIPIAPQSVCEGLIEPSVLSIDKPLENIKANRGDSLVLRCAFYASPQPTIVWYHRGKRVDSHPAAHFETLLSATNLGQSVVESALRIDCLDERTAGEYFCEATSPCTQPVVTSSTVTINKAPKSITGTCKSIRQPLESPPIVSDFTLSRIELPGGVAQLACRVRGVPTPKTKWFKIEEDESLSTIDGQPNYMHLSNGDLLIVGDEETISESFRCVASNPLGSVHQDASVIYMMA
Protein: Anamorsin homolog (Fe-S cluster assembly protein DRE2 homolog) (Q8L7Z3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via FAD- and FMN-containing diflavin oxidoreductase TAH18/ATR3. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Required for embryo development.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03115}. Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03115}.
Interaction partners:
- NADPH-dependent diflavin oxidoreductase 1
- Protein BOLA2
- NADPH-dependent diflavin oxidoreductase
- Monothiol glutaredoxin-S17
- Protein BOLA1
- Monothiol glutaredoxin-S15, mitochondrial
- Cytosolic Fe-S cluster assembly factor NBP35
- Monothiol glutaredoxin-S14, chloroplastic
- Bifunctional monothiol glutaredoxin-S16, chloroplastic
- MMS19 nucleotide excision repair protein homolog
Sequence:
MDSMMNQKTVLAVTDDVVLPVSSVLAIMKELGKEVIESFDPLIITQASTINQFPLDASSVEAVLAISKTSDFPSDKICGEFSRILKPGGTVSVCKVLEGETGEIQQTIQRRVTLAGFLEPQCLDLKSIKLSTFSLSFGIKAKKPSWKIGSSFALKKPVTNLFKIDLDDDVDLIDEDSLLTEEDLMKPQLPVASGCETTKKACKNCVCGRAEIEEKAVKLGLTEDQIENPQSSCGSCGLGDAFRCGTCPYKGLPPFKLGEKVTLSQNFLEADI
Protein: Low-density lipoprotein receptor (LDL receptor) (P01131)
Organism: Bos taurus (Bovine)
Function: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
Subcellular location: Cell membrane {ECO:0000269|PubMed:6313699}; Single-pass type I membrane protein {ECO:0000269|PubMed:6313699}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:P01130}. Golgi apparatus {ECO:0000250|UniProtKB:P01130}. Early endosome {ECO:0000250|UniProtKB:P01130}. Late endosome {ECO:0000250|UniProtKB:P01130}. Lysosome {ECO:0000250|UniProtKB:P01130}. Note=Rapidly endocytosed upon ligand binding. {ECO:0000250|UniProtKB:P01130}.
Interaction partners:
- Low density lipoprotein receptor adapter protein 1
- E3 ubiquitin-protein ligase MYLIP
- Apolipoprotein B
- DAB adaptor protein 2
- Hydroxymethylglutaryl-CoA synthase
Sequence:
MRLAGWGLRWAIALLIAVGEAAVEDNCGRNEFQCQDGKCISYKWVCDGTAECQDGSDESQETCKSVTCKMGDFSCGGRVNRCISGSWRCDGQVDCENGSDEEGCSPKTCSQDEFRCNDGKCIAPKFVCDLDLDCLDGSDEASCPMPTCGPANFQCNSSMCIPQLWACDGDPDCDDGSDEWPKHCGTPHPSGPLQDNNPCSALEFHCGSGECIHSSWHCDHDPDCKDKSDEENCAVATCRPDEFQCSDGTCIHGSRQCDREPDCKDLSDELGCVNVTLCEGPNKFKCQSGECISLDKVCNSVRDCRDWSDEPLKDCGTNECLDNKGGCSHICNDLKIGYECLCPEGFQLVGKHRCEDIDECQNPDTCSQLCVNLEGSYKCECEEGFRLEPLTKACKAVGTIAYLFFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVASNRIYWSDLSQRKIYSAQIDGAPGFSSYDTVIGEDLQAPDGLAVDWIHSNIYWTDSILGTVSVADTKGVKRKTLFQEEGSKPRAIVVDPVHGFMYWTDWGAPAEIKKGGLNGVDVYSLVTEDIQWPNGITLDLSGGRLYWVDSKLHSISSIDVNGGNRKTVLEDKKKLAHPFSLAIFEDKVFWTDVINEAIFSANRLTGSDISLMAENLLSPEDIVLFHNLTQPRGVNWCERTALRNGGCQYLCLPAPQINPRSPKFTCACPDGMLLAKDMRSCLTESESAVTTRGPSTVSSTAVGPKRTASPELTTAESVTMSQQGQGDIASQADTERPGSVGALYIVLPIALLILLAFGTFLLWKNWRLKSINSINFDNPVYQKTTEDEVHICRSQDGYTYPSRQMVSLEDDVA
Protein: Upstream activation factor subunit spp27 (Upstream activation factor 27 KDa subunit) (p27) (Upstream activation factor 30 KDa subunit) (p30) (Upstream activation factor subunit uaf30) (O74503)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. UAF seems to stimulate basal transcription to a fully activated level.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- RNA polymerase I-specific transcription initiation factor rrn10
- RNA polymerase I-specific transcription initiation factor rrn5
- RNA polymerase I-specific transcription initiation factor rrn11
- Uncharacterized protein C3B8.11
- RNA polymerase I-specific transcription initiation factor rrn7
- Chromatin structure-remodeling complex subunit sfh1
- TATA-box-binding protein
- RNA polymerase I-specific transcription initiation factor RRN9 homolog
- RNA polymerase I-specific transcription initiation factor rrn3
- DNA topoisomerase 1
Sequence:
MEEYETDIKQILGTVDRQTVSAKQVRQLLEERRKVDLSAHKKDLNALILKCFDETAAPSEKESLEKQAPARKTKGKRATENGTEEGKKPAKRTRKRKEDGEEGGKRKRNQDPANNPLNKPMKLSPKLAEFLGLEQLSRPQTVKKLWEYIKAHDLQDPNDKRTILCDDKLKSVFEVDTLHMFTMNKYLTNLMTKIPDDQLPKPQPKNEEPAAPNDLPKQEEKELVEPPTAESTA
Protein: Ubiquitin-like protein activating enzyme N subunit (Q7KJV5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVVDMDTSETAVELTEAENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFDVVVVNGATNEELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVANSEKKKKYETVSIPTQRDVDYPGYSAWLDFDVTEPSYLRKLKRNGPGVLLLSVLQKFRTTHKRDPSYKTREADLELLRGIRDELLPNSILGNEALGLIFAQISPAVAVVGGVVAQEVIKVVTKLEAPHRNLFVFDPETCAGYVEAIGAK