Protein: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) (P04191)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12585965}; Multi-pass membrane protein {ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:12167852, ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:15448704, ECO:0000269|PubMed:15618517, ECO:0000269|PubMed:16710301, ECO:0000269|PubMed:18075584, ECO:0000269|PubMed:23455422, ECO:0000269|PubMed:23455424, ECO:0000269|PubMed:23996003, ECO:0000269|PubMed:24270570, ECO:0000269|PubMed:26175901, ECO:0000269|PubMed:28467821, ECO:0000269|PubMed:30482857}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:11438520, ECO:0000269|PubMed:15189864, ECO:0000269|PubMed:18075584, ECO:0000269|PubMed:23455422, ECO:0000269|PubMed:23996003, ECO:0000269|PubMed:29081402, ECO:0000269|PubMed:8117720}; Multi-pass membrane protein {ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:12167852, ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:15448704, ECO:0000269|PubMed:15618517, ECO:0000269|PubMed:16710301, ECO:0000269|PubMed:18075584, ECO:0000269|PubMed:23455422, ECO:0000269|PubMed:23455424, ECO:0000269|PubMed:23996003, ECO:0000269|PubMed:24270570, ECO:0000269|PubMed:26175901, ECO:0000269|PubMed:28467821, ECO:0000269|PubMed:30482857}.
Interaction partners:
- Sarcolipin
- Phospholamban
- Ryanodine receptor 1
- Myosin regulatory light chain 11
- Sarcalumenin
- Calsequestrin-1
- Troponin T, fast skeletal muscle
- Chloride channel protein 1
- Muscleblind like splicing regulator 1
- F-actin cross-linking protein
Sequence:
MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDKPIRSGQFDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRNLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGPVKEKILSVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGMLDPPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFMYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTMALSVLVTIEMCNALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLKALDLTQWLMVLKISLPVIGLDEILKFIARNYLEDPEDERRK