wanglab/gogpt-training-data huggingface dataset:
Protein: Cadherin-9 (Q9ULB4)
Organism: Homo sapiens (Human)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Catenin beta-1
- Taste receptor type 2 member 1
- Cadherin-12
- Semaphorin-5A
- Neuroligin-4, X-linked
- Catenin alpha-1
- Cadherin-13
- Contactin-4
- Cadherin-18
- Cadherin-2
Sequence:
MRTYHYIPLFIWTYMFHTVDTILLQEKPNSYLSSKKIAGLTKDDGKMLRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGRIKANDPDVGENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDASNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYDPDARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFEPVPEFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVCACDNQGNMQSCTAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKKEPLIISKDDVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIRRTVPLWENIDVQDFIHRRLKENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADCNQDYDYLSDWGPRFKKLADMYGGDDSDRD
Protein: Inner kinetochore subunit cnp20 (CENP-T homolog) (Centromere protein 20) (Constitutive centromere-associated network protein cnp20) (Q9HGK9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H3-like centromeric protein cnp1
- Inner kinetochore subunit mhf2
- Inner kinetochore subunit mhf1
- Inner kinetochore subunit wip1
- Inner kinetochore subunit cnp3
- Inner kinetochore subunit fta1
- Putative nucleosome assembly protein C36B7.08c
- Histone acetyltransferase type B subunit 2
Sequence:
MASHNYETPLKSSSFQHLVGTLSQRRHFTPSRSRYTPRSAQRTVTPHKRRALARRNSLARRRSNVFSATTPRDILRMLSRALAKNPVPSPAESESSERRHTPQTNSQKSQKTPRLSSNKRRTLKNDAKQRNSQSPGTDTSDANLTIQSIEAPRRAPQRLSDFFTPDGRRVSNIRDSLISEKRLENNIDQVQESALSTASSNRLIDLKNDEVPIFRIPLSDYETDDMDDGTPLQRHVATLNQYQSPIFNLGPDILEDEPSYSSRASRSRQSSLSSRLSELPSKRASLEILRRENTFPADPIQEFGEKAYNERELMEEISNFEPLLDDNLLENANEAVNSPVVDAPMDADSALEIPNDEDNGEILNKLKDSPFKKPKRRYSKSSTLVLPETNIRKLANSYSQKKIAGSVIEELTTASELFFKQIANDLSAFADHAHRKTIDTQDVVLLMKRQRKISEKKSLSSLMQQYLSREIAPPAIKRT
Protein: Plasmodium RESA N-terminal domain-containing protein (Q8I206)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Uncharacterized protein
- Secreted ookinete protein, putative
- Clustered-asparagine-rich protein
- Uncharacterized protein
- Homeobox-containing protein
Sequence:
MCNKLSRGSNMNKSELGDRSTKMKGKICSSYVKYICLTICVIGMLCIKLRDKYEGYAASGIQNNNVYLRNLSELQKGNQPCLRHTNRTDNSKMNKVKNNNQTENNDNKKKLGNKEDNQGKNKNNNNKEKQNDINKRGTQNTETKKSNKKLSQDYNDVNKKFTKEQMKNLVNSLDEIPPRNDMEKIWNHAVKTANSGTSRIKKKLKEYEQKYGRCYEERPNRFGSYEQVLISQPHEFNERLKVHENDYTVFFYELLDKDPTLDEIKNYITSFLEGFQNLIDFLFNKYKIIFLQTTTEIPIDGTIYDTSKKDMKKNKNKKQNIKQGGKKEEVKQEGKKEEVKQEGKKEEVKQEGKKEEVKQEGKKEEVKQGGKKEEVKQGGKKEEVKQGGKKEEVKQGGKKEEVKQGGKKEEVKQGGKKEEVKKELKKNN
Protein: Utrophin (A0A1W2P6L4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLCQGEMEETSVATDGASRESQADEHNDVQKKTFTKWINARFSKSGKPPISDMFSDLKDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVDLVNIGGTDIVDGNPKLTLGLLWSIILHWQVKDVMKDIMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVL
Protein: HTH-type transcriptional regulator VirS (Virulence-regulating protein VirS) (P9WMJ3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Regulates the expression of the mymA operon (Rv3083-Rv3089).
Interaction partners:
- Putative FAD-containing monooxygenase MymA
- HTH-type transcriptional regulator Rv1931c
- Probable transcriptional regulatory protein
- AB hydrolase-1 domain-containing protein
- Transcriptional regulatory protein EmbR
- Probable transcriptional regulatory protein
- Transcriptional regulatory protein
- Uncharacterized protein Rv1359
- Probable ECF RNA polymerase sigma factor SigI
- Transcriptional regulatory protein
Sequence:
MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQEDAFMSLAGFVRMLEASAAELDCPDFGLRLARWQGLGILGPVAVIARNAATLFGGLEAIGRYLYVHSPALTLTVSSTTARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGPQARARVFSFRHAQLGTDAAYREALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRIATKYLESQYLPSDATLSERVVGLARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGLRCHDLIERERRAQAARYLAQPGLYLSQIAVLLGYSEQSALNRSCRRWFGMTPRQYRAYGGVSGR
Protein: Interleukin 15 receptor subunit alpha (A0A8I6G839)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MASPQLRGCGVHALPMLLPLLLLLLLLLPLRVTPGITCPTPISIEHADIRVKNYSVNSRERYVCNSGFKRKAGTSTLTECVINKNTNVAHWTTPNLKCIRDPSLAHYSPVPTVVTPKVTSQPESLSPPEKEISPHSSEMTKVAIPTSVLLVAAGIGLVFLTRYIKSRQASQPRRVEVETMETVPMTVRARSKEDEDHTTSETQGDQPTRGV
Protein: Nuclear factor 1 (A0A1B0GW37)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
Sequence:
MDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQSWYLG
Protein: YAP1-binding protein 2 (YBP1 homolog protein 1) (P53169)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in oxidative stress response and redox homeostasis. Required for hydrogen peroxide-induced activation of YAP1. Acts in a parallele pathway to YBP1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15075262}.
Interaction partners:
- Kinetochore protein NUF2
- Outer kinetochore KNL1 complex subunit SPC105
Sequence:
MYNEQVNSGKSIKEKERYLDALLKILKDNPVTLKEIGWDLPKGLLQFFSRKNINVNIHLVFSPLVSSVMECFNELAINGNPKECLLTACELVSTLHIVLTETGDSDEENEDLNDSNRNDASNITDELSVITPEIGHYMAKNTVEFIPNLKIYVLFEFMSLLLKRVDTLYPSKFLAMVTSAIIKYVTTNVQAMDDPHFILRIVYNFCTNYSPAQPSASLTDGISTNDLEKIHDDESALQKKLLANLSVFVISNCLKNHPGNIDKIYFKTLMHKKTDENEIDASVLQICHQYYEYVTSLDVHMKELLEKCLVESRSIYNSLLMNPAASTPEFKEEINQLVYEVSYAYQIKKLADEKNLELDQYGVVILSAIHYSKNGTHLLPQIDIQSAIYLYLRCTTASLFSEIYENKFLESSVRYWLWVSTTETSTEKIKCALQELPGHITTAFLQMLLMKTCNESNNDTKLTEITLLRRLLYLMPESTSFTFIFETLLHCPYITAKIAVLDILRDMMIRSPEAANRDETVGLIEQQNPGNTANSVPIMPTLPPRPYITINEDRMASIHSIALICFSAAKQKKRTQGDLLLVLTYMKFFVSLRNKWDLGLLTLINKEISESFQGEGEPELAFINISNNTLGEYIEEMNIRS
Protein: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) (P13286)
Organism: Rattus norvegicus (Rat)
Function: Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity).
Interaction partners:
- Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
- Phosphorylase b kinase regulatory subunit
- Phosphorylase b kinase regulatory subunit
- Calmodulin-1
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
- Calmodulin-like protein 3
- Calmodulin-like protein 4
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Glycogen phosphorylase, muscle form
Sequence:
MTRDEALPDSHSAQNFYENYEPKEILGRGVSSVVRRCIHKPTCQEYAVKIIDITGGGSFSSEEVQELREATLKEVDILQKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLTEKETRKIMRALLEVVCTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLQPGEKLREVCGTPSYLAPEIIQCSMDEGHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYSDTVKDLVSRFLVVQPQDRCSAEEALAHPFFQEYVVEEVRHFSPRGKFKVICLTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEEEDF
Protein: Uncharacterized protein At5g49945 (Q94CC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Nicalin
- BOS complex subunit TMEM147
- Calcium load-activated calcium channel
- Calcium load-activated calcium channel
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL18y
- Protein Asterix
- F9K20.24 protein
- SecY protein transport family protein
- AT2G34250 protein
Sequence:
MSRYFSFFFLALFLHYRIIVASPFEGFDAEEDDVTDDSSHLLHHSLPPPLLTQSHSSLSDPDPEPEPSSAECKSDLITESDLEHQSDSKTPSSTPFEYWDEDEFEGLPVEIETLESPLITENGTHADPKTPDLKTSSEAQGDTNDQTKKKKSYAVEIACVCFLIALAINYFVGKRENESLALAWAAKFASKDTIFQKNFSMLGVSELEDSPLLLKEALNVFKFYASGRRYCHGLLATMELKSRHDLISRVFNLVVPCKDEITFEVYMNEETMDHVVFAMTKKKAAKTMQKEMRDLQRFAGIVSPPAGRKWVSEEFALISESKEVAADLITDTVLDQVFGDKAVDKYGKNFMSMHISDQHPGKHKKMMLFKFSLPDAKHMDDIVRLVALIPYYIDLVGRYRLSSQARNKTESGRQKAAEEAYKELHNARQEALQKKKAEKKKMMEEAEAKMSAEVIRKKEAKERARQVKKAVPKMKMSRSH
Protein: Predicted gene 4924 (Q3UF22)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
SGQKPCEYNQSGKAFAQNSHLFHHEIDHTQEKSYGCSQCGKAFAYNSQLQRHERSHTGEKPYGCNKCGKAFAQKNNLHSHERSHTGEKPYECKKCGKAFSQNSHLHKHERSHTGEKPYGRKQCDKAFAQNSHLFHHEINCTQEKSYGCSQCGKAFGRYSNLQRHERSHTGEKPYECNKCGKAFSQNSHLHKHERSHTGEKPYECNQCLKAFACKSNLYRHERRHT
Protein: RNA-binding protein 8A (Protein tsunagi) (Q9V535)
Organism: Drosophila melanogaster (Fruit fly)
Function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte.
Subcellular location: Nucleus {ECO:0000269|PubMed:12730685}. Cytoplasm {ECO:0000269|PubMed:12730685}. Note=Part of the EJC assembled on mRNAs in the nucleus and remains part of the complex when mRNA moves into the cytoplasm.
Interaction partners:
- Partner of Y14 and mago
- Protein CASC3
- Eukaryotic initiation factor 4A-III
- Protein mago nashi
- LD23870p
- RE04053p
- FI21285p1
- Nuclear cap-binding protein subunit 2
- ATP-dependent RNA helicase WM6
- LD40489p
Sequence:
MADVLDIDNAEEFEVDEDGDQGIVRLKEKAKHRKGRGFGSDSNTREAIHSYERVRNEDDDELEPGPQRSVEGWILFVTSIHEEAQEDEIQEKFCDYGEIKNIHLNLDRRTGFSKGYALVEYETHKQALAAKEALNGAEIMGQTIQVDWCFVKGPKRVKKSEKRRR
Protein: Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial (CPS) (CPSase) (EC 6.3.4.16) (EC 6.3.5.5) (Ammonium-dependent carbamoyl phosphate synthetase) (Arginine-specific carbamoyl phosphate synthetase, ammonia chain) (Glutamine-dependent carbamoyl phosphate synthetase) (O94313)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:200419}.
Interaction partners:
- Carbamoyl phosphate synthase arginine-specific small chain
- Argininosuccinate synthase
- Ornithine carbamoyltransferase, mitochondrial
- Dihydroorotate dehydrogenase
- Amidophosphoribosyltransferase
- Glutamate synthase
- Glutamine synthetase
- Protein arg11
- Probable glutamine--fructose-6-phosphate aminotransferase
- Multifunctional protein ura1
Sequence:
MALWATSMRRAIPGISKAFLGSNRVLETAGVSQLSKHLLPQWSGVPHRKISASATNFNDKVKESNTPDANAYIRSGHIKAAEHEKVKKVVVVGSGGLSIGQAGEFDYSGAQAIKALRESSVHTILINPNIATIQSSHSLADEIYFLPVTAEYLTHLIERENPDGILLTFGGQTALNVGIQLDDMGVFARNHVKVLGTPISTLKTSEDRDLFAKALNEINIPIAESVAVSTVDEALQAAEKVSYPVIIRSAYSLGGLGSGFANNKEELQSMAAKSLSLTPQILVEKSLKGWKEVEYEVVRDAANNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEEYHMLRTAAIKIIRHLGVVGECNVQYALSPNSLEYRVIEVNARLSRSSALASKATGYPLAYTAAKIALGHTLPELPNAVTKTTTANFEPSLDYVVTKIPRWDLSKFQYVNREIGSSMKSVGEVMAVGRTFEESLQKALRQVDPSFLGFMAMPFKDLDNALSVPTDRRFFAVVEAMLNQGYSIDKIHDLTKIDKWFLSKLANMAKVYKELEEIGSLYGLNKEIMLRAKKTGFSDLQISKLVGASELDVRARRKRLDVHPWVKKIDTLAAEFPAHTNYLYTSYNASSHDIDFNEHGTMVLGSGVYRIGSSVEFDWCGVSCARTLRKLGHSTIMVNYNPETVSTDFDECERLYFEELSYERVMDIYEMETASGIVVSVGGQLPQNIALKLQETGAKVLGTDPLMIDSAEDRHKFSQILDKIGVDQPAWKELTSVAEASKFANAVGYPVLVRPSYVLSGAAMSVIRDESSLKDKLENASAVSPDHPVVITKFIEGARELDVDAVASKGKLLVHAVSEHVENAGVHSGDATIALPPYSLSEDILSRCKEIAEKVCKAFQITGPYNMQIILAQNPDKPDTPDLKVIECNLRASRSFPFVSKTLGVNFIDVATRSIIDQEVPAARDLMAVHRDYVCVKVPQFSWTRLAGADPYLGVEMSSTGEVACFGKDVKEAYWAALQSTQNFKIPLPGQGILLGGDRPELAGIAADLSKLGYKLYVANKDAAKLLQPTSAEVVEFPVKDKRALRAIFEKYNIRSVFNLASARGKNVLDQDYVMRRNAVDFNVTLINDVNCAKLFVESLKEKLPSVLSEKKEMPSEVKRWSEWIGSHDL
Protein: HTH-type transcriptional regulator cbl (Q47083)
Organism: Escherichia coli (strain K12)
Function: May be an accessory regulatory protein within the cys regulon.
Interaction partners:
- Nitrogen assimilation regulatory protein nac
Sequence:
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVAFPWFRWHHSLLVPHDHPLTQISPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGIGLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMESSEEEIDYQI
Protein: ADP-ribosylation factor GTPase activating protein 1, isoform A (RE63354p) (Q9VTX5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- ADP-ribosylation factor 1
- Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
- ADP-ribosylation factor GTPase activating protein 3, isoform H
- Mannosyl-oligosaccharide glucosidase
- Coatomer subunit beta'
- ADP-ribosylation factor-like protein 1
- ADP-ribosylation factor 6
- Coatomer subunit gamma
- Secretory 22, isoform B
- BET1 homolog
Sequence:
MASPRTRRVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDKWKDIELEKMKAGGNRNAREFLEDQEDWNERAPITQRYNSKAAALYRDKIATLAQGKSWDLKEAQGRVGSNNSFSSGGSSNSSYQSRPSATGYGGNGGYQNGGGAEPGGYQQYQTQEFKDQKEEFFSRRQVENASRPENLPPSQGGKYAGFGFTREPPPKTQSQELFDSTLSTLASGWSLFSTNASKLASTAKEKAVTTVNLASTKIKEGTLLDSVQCGVTDVASKVTDMGKRGWNNLAGSNISSPQGGYNDPNFEDSSAYQRSNSVGGNLAGGLGQQSGVSDSDWGGWQDNGNSKSHMTSSSSYHNQLSSSSGGGTASAGLTRDADWSGFEATNYQSSETSYQNASSGGSTARRNMKLQDTSQKLSEGFESLDVKSVKPKTATASSANKGTAEDDAWNLLMN
Protein: Butyrophilin-like protein 2 (O70355)
Organism: Mus musculus (Mouse)
Function: Negative regulator of T-cell proliferation.
Subcellular location: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MVDCPRYSLSGVAASFLFVLLTIKHPDDFRVVGPNLPILAKVGEDALLTCQLLPKRTTAHMEVRWYRSDPDMPVIMYRDGAEVTGLPMEGYGGRAEWMEDSTEEGSVALKIRQVQPSDDGQYWCRFQEGDYWRETSVLLQVAALGSSPNIHVEGLGEGEVQLVCTSRGWFPEPEVHWEGIWGEKLMSFSENHVPGEDGLFYVEDTLMVRNDSVETISCFIYSHGLRETQEATIALSERLQTELASVSVIGHSQPSPVQVGENIELTCHLSPQTDAQNLEVRWLRSRYYPAVHVYANGTHVAGEQMVEYKGRTSLVTDAIHEGKLTLQIHNARTSDEGQYRCLFGKDGVYQEARVDVQVMAVGSTPRITREVLKDGGMQLRCTSDGWFPRPHVQWRDRDGKTMPSFSEAFQQGSQELFQVETLLLVTNGSMVNVTCSISLPLGQEKTARFPLSGW
Protein: Methylesterase 18 (AtMES18) (EC 3.1.1.-) (Q9LVL9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methylesterase shown to have methyl indole-3-acetic acid (MeIAA) esterase activity in vitro.
Interaction partners:
- Cytochrome P450 71B8
- Probable carboxylesterase 1
- Cytochrome P450 710A3
Sequence:
MSEHHFVFVHGAGHGGWCWYKLANSLRDNGHKATCIDLKGAGINPTDPNTVSSLDDYDEPLYAFLSQLPNDQKVILVSHSVGGGSMTAAMCLFPSKVSLAVYVAAAMVKPGTLIPERLKNVMKICSGLIEEETEKIWDFTFGNGPQNLPTSIMMKPEYVRDKFYNESPMEDYTLATTLLRPAPVMAFIGIMDIPGAPETDKIPRVYVKTGKDHLFEPVLQEVMLALWPPAHTFLLPDSDHSAFFSQPQELYQFLLQAASSLSP
Protein: Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Yolk sac permease-like molecule 3) (Q9Z2J0)
Organism: Mus musculus (Mouse)
Function: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:36749388}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UHI7}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Uridine 5'-monophosphate synthase
Sequence:
MKTPEDPGSPKQHEVVDSAGTSTRDRQAPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKSILALERWKCPSEEEIYGNWSMPLNTSHIWHPRIREVQGAIMVSSMVEVVIGLMGLPGALLSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLRNLTFLLPVYRWGKGLTLFRVQIFKMFPIVLAIMTVWLLCYVLTLTDVLPADPTVYGFQARTDARGDIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGIPEVDQILTVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSETSASLKSYDFPFGMGMVKRTTFFRYIPICPVFRGFSKKTQNQPPVLEDTPDNIETGSVCTKV
Protein: Capsular polysaccharide biosynthesis protein Cps4G (A0A0H2UNE9)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MRVLFILSDNIYLTPYFNFYKELLKKLSISYDVIYWDKNINEIITKQNYYRISFSGKGKLSKILGYVKFRKEIKKKLKENDYDMILPLHSIVSFILVDFLLFSFKNRYIYDIRDYSYEKFLVYRLVQKQLVKNSLMNIVSSDGYKFFLPMGEYFTTHNLPNMIELNEVKQLKNNSTFPIQLSYIGLIRFQEQNKKIIDFFANDSRFQLNFIGTNAGELREFCQEKNISNVNLVDTFQPKDTMSFYKNTDVVLNLYGNHTPLLDYALSNKLYFAALLYKPILVCEDTYMEKVSIENGFGFVLPMKDESEKDCLALYIQNLDRKQLIKNCDNFMDRISLEKQKTEIELEKRILSLRKKND
Protein: D-galactonate dehydratase family member VME_00770 (D0X4R4)
Organism: Vibrio harveyi (strain 1DA3)
Function: Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
Interaction partners:
Sequence:
MNKNTISNIECVITKPDRHNLITVIVETESGVTGYGCATFQQRPLAVKTMVDEYLKPLLIGKDANNIEDLWQMMMVNAYWRNGPVINNAISGVDMALWDIKAKIANMPLHQLFGGKSRDAIQVYTHATSDTMEGLYEQVDKYLEQGYQHIRCQLGFYGGVPENIQTAQNPTQGSYYDQDQYIENTVEMFKNLREKYGKQFHILHDVHERLFPNQAIQFAKQIEQYNPFFIEDILPPSQTEWLDNIRNQSSVSLALGELFNNPEEWKALIINRRVDFIRCHVSQIGGITPALKLGHFCESFGVRIAWHCPPDMTPIGAAVNTHLNVHLHNAAIQEHVEYKANTQRVFPNAAEPINGYLYASEIAGIGVEMDREAAQDFPVEYRPHEWTQSRLPDGSIHTP
Protein: Ras and Rab interactor-like protein (Q80UW3)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members.
Subcellular location: Cell projection, ruffle {ECO:0000269|PubMed:21419809}. Cytoplasmic vesicle {ECO:0000269|PubMed:21419809}.
Interaction partners:
- Rab5 GDP/GTP exchange factor
Sequence:
MRLAQPDMVSAAPTEVDRLVWPLADGADKSPLGVLSTTEPLLRLQRTQRVWEVPELDAQYAKAFLELWPLGSFLVIGHEPGQVLMLKAGPSSGDINTYQIQRFPGGVSLESSNLCMPDCPHLLAFLSASRDVLPRTLLLPTPTVGAGDNHSDPHRLGCIQVDTSGRVLSVVNQLYLETHGGWGTETPQQTEPETGQKYSLAPRKPTPHRVSWVEDPLRPEAHHTGQEVHHPGADAHSLGSEVHFSCPALEEEEVNNDCYKDEDEEGCEDMLTAHIRALARTRSSYVARQYRCLRARLISDSGNPYSPGDPATELLQDVRQLLTDLQNYLAKDPDVRAVFGNRGPSILREEDLGPAVEVALCRAVLEPLKPALWTKLRTLRAQELRRLRRRQIALRVGAGPEGQSPALRNRNRIHARLAHLHAACAPRRKVALLLAVCSDVYAGLGGGENKEPLGADAFLPALTEELIWSPHIGETQLDVEFLMELLDPGELRGEAGYYLTTWFGALYHIAHYQPDTGRAPQGLSSEARASLRQWHRRRTLHQQAQPTAQANQPFEEPWAIGDP
Protein: Histone acetyltransferase RTT109 (EC 2.3.1.48) (Regulator of Ty1 transposition protein 109) (Q07794)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Histone chaperone-dependent acetylase that modifies 'Lys-9', 'Lys-14', 'Lys-23', 'Lys-27', and 'Lys-56' on histone H3 (H3K9Ac, H3K14Ac and H3K23Ac, H3K27Ac, and H3K56Ac) to promote nucleosome assembly, genomic stability, DNA repair and transcriptional regulation during mitotic S-phase. Its residue selectivity is influenced by the acetylation status of histone H3, and also the presence of histone chaperone ASF1 that shifts selectivity to 'Lys-56' when H3K14Ac is already present. H3K56 acetylation weakens the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly. Autoacetylates. Independently of acetyltransferase activity, stimulates histone deposition by VPS75. Involved in regulation of Ty1 transposition.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15282802}.
Interaction partners:
- Histone chaperone ASF1
- Histone H3
- Vacuolar protein sorting-associated protein 75
- Histone H4
- Histone acetyltransferase GCN5
- NAD-dependent histone deacetylase HST3
- NAD-dependent histone deacetylase HST4
- Histone chaperone RTT106
- DNA repair and recombination protein RAD52
- E3 ubiquitin-protein ligase substrate receptor MMS22
Sequence:
MSLNDFLSSVLPVSEQFEYLSLQSIPLETHAVVTPNKDDKRVPKSTIKTQHFFSLFHQGKVFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNTRVSVRDITKIILEFILSIDPNYYLQKVKPAIRSYKKISPELISAASTPARTLRILARRLKQSGSTVLKEIESPRFQQDLYLSFTCPREILTKICLFTRPASQYLFPDSSKNSKKHILNGEELMKWWGFILDRLLIECFQNDTQAKLRIPGEDPARVRSYLRGMKYPLWQVGDIFTSKENSLAVYNIPLFPDDPKARFIHQLAEEDRLLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLATPSLFPSSADVIVPKSRKQFRAIKKYITGEEYDTEEGAIEAFTNIRDFLLLRMATNLQSLTGKREHRERNQPVPASNINTLAITMLKPRKKAKALPKT
Protein: Myoblast determination protein 1 homolog (MyoD protein 1) (Helix-loop-helix protein 1) (P22980)
Organism: Caenorhabditis elegans
Function: Involved in myogenesis, in cooperation with transcription factors unc-120 and hnd-1. Acts redundantly with fozi-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2.
Subcellular location: Nucleus {ECO:0000269|PubMed:2175254}.
Interaction partners:
- Helix-loop-helix protein hlh-2
Sequence:
MNTETSTQSAPSDTYDTSIYYNSSPRVTANDITTLTSFAAPAPQVLDYANTQYDIYRNQPAYYLPSYAPTAPTTFYSDFANFNVTRSQDFASVPAVANSSDVKPIIIKQEKSTPNATELIIQSRVDSQHEDTTTSTAGGAGVGGPRRTKFVLSVDRRKAATMRERRRLRKVNEAFEVVKQRTCPNPNQRLPKVEILRSAIDYINNLERMLQQAGKMTKIMEQNQHLQMTQQINGAPPHDYVTSSHFASSSYNPENMFDDDDLTDSDDDRDHHKLGNAVDLRRRNSLDRLSRIVASIPNEEAMTDEQLLQPANDVIDGEKKLEML
Protein: Tyrosine recombinase XerC (P0A8P6)
Organism: Escherichia coli (strain K12)
Function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids at ColE1 xer (or cer) and pSC101 (or psi) sites. In the complex XerC specifically exchanges the top DNA strands (By similarity).
Subcellular location: Cytoplasm. Note=Associated with DNA.
Interaction partners:
- Tyrosine recombinase XerD
- DNA translocase FtsK
- Diaminopimelate epimerase
- Uncharacterized protein YigA
- 5-amino-6-
- Crossover junction endodeoxyribonuclease RuvC
- Holliday junction branch migration complex subunit RuvB
- Holliday junction branch migration complex subunit RuvA
- Arginine repressor
- Prophage integrase IntR
Sequence:
MTDLHTDVERYLRYLSVERQLSPITLLNYQRQLEAIINFASENGLQSWQQCDVTMVRNFAVRSRRKGLGAASLALRLSALRSFFDWLVSQNELKANPAKGVSAPKAPRHLPKNIDVDDMNRLLDIDINDPLAVRDRAMLEVMYGAGLRLSELVGLDIKHLDLESGEVWVMGKGSKERRLPIGRNAVAWIEHWLDLRDLFGSEDDALFLSKLGKRISARNVQKRFAEWGIKQGLNNHVHPHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK