wanglab/gogpt-training-data huggingface dataset:
Protein: Betacellulin (Q9JJM4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Receptor protein-tyrosine kinase
- Receptor tyrosine-protein kinase erbB-4
- Receptor tyrosine-protein kinase erbB-3
- Pro-epidermal growth factor
- Pro-epidermal growth factor
- Epigen
- Proepiregulin
- Pro-neuregulin-1, membrane-bound isoform
- Amphiregulin
- Receptor tyrosine-protein kinase erbB-2
Sequence:
MDSTAPGSGVSSLPLLLALVLGLVILQCVVADGNTTRTPETNGSLCGAPGENCTGTTPRQKSKTHFSRCPKQYKHYCIHGRCRFVMDEQTPSCICEKGYFGARCEQVDLFYLQQDRGQILVVCLIGVMVLFIILVIGVCTCCHPLRKHRKKKKEEKMETLSKDKTPISEDIQETNIA
Protein: EPIDERMAL PATTERNING FACTOR-like protein 9 (EPF-like protein 9) [Cleaved into: Stomagen] (Q9SV72)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Positively regulates stomatal density and patterning. Acts by competing with EPF2 (AC Q8LC53) for the same receptors, ERECTA (AC Q42371) and TMM (AC Q9SSD1). Not cleaved by the protease CRSP (AC Q9LNU1).
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:20007289, ECO:0000269|PubMed:20010603}. Secreted {ECO:0000269|PubMed:20007289, ECO:0000269|PubMed:20010603}.
Interaction partners:
- Protein EPIDERMAL PATTERNING FACTOR 2
- Protein EPIDERMAL PATTERNING FACTOR 1
- Transcription factor MUTE
- Transcription factor SPEECHLESS
- LRR receptor-like serine/threonine-protein kinase ERL1
- EPIDERMAL PATTERNING FACTOR-like protein 6
- EPIDERMAL PATTERNING FACTOR-like protein 4
- LRR receptor-like serine/threonine-protein kinase ERL2
- Transcription factor FAMA
- Subtilisin-like protease SBT1.2
Sequence:
MKHEMMNIKPRCITIFFLLFALLLGNYVVQASRPRSIENTVSLLPQVHLLNSRRRHMIGSTAPTCTYNECRGCRYKCRAEQVPVEGNDPINSAYHYRCVCHR
Protein: Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript protein) (Transmembrane BAX inhibitor motif-containing protein 6) (P55061)
Organism: Homo sapiens (Human)
Function: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21068390, ECO:0000269|PubMed:21075086, ECO:0000269|PubMed:22128171}; Multi-pass membrane protein {ECO:0000269|PubMed:21075086, ECO:0000269|PubMed:22128171}.
Interaction partners:
- Desumoylating isopeptidase 1
- Apoptosis regulator BAX
- Bcl-2-like protein 1
- Apoptosis regulator Bcl-2
- Bcl-2 homologous antagonist/killer
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Beclin-1
- Presenilin-1
- Protein lifeguard 1
Sequence:
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMGTAMIFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSLGNVFFGSIWLFQANLYVGLVVMCGFVLFDTQLIIEKAEHGDQDYIWHCIDLFLDFITVFRKLMMILAMNEKDKKKEKK
Protein: ER-derived vesicles protein ERV15 (P38312)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Spore membrane assembly protein 2
- Protein ERP2
Sequence:
MSGTGLSLFVTGLILNCLNSICQIYFTILYGDLEADYINSIELCKRVNRLSVPEAILQAFISALFLFNGYWFVFLLNVPVLAYNASKVYKKTHLLDATDIFRKLGRCKIECFLKLGFYLLIFFFYFYRMVTALLENDANLIS
Protein: Transcription termination factor 3, mitochondrial (Mitochondrial transcription termination factor 3) (mTERF3) (mTERF domain-containing protein 1, mitochondrial) (Q96E29)
Organism: Homo sapiens (Human)
Function: Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:17662942, ECO:0000269|PubMed:23300484}.
Interaction partners:
- FAST kinase domain-containing protein 2
- Probable ATP-dependent RNA helicase DDX28
- Transcription termination factor 1, mitochondrial
- Pseudouridylate synthase TRUB2, mitochondrial
- Transcription termination factor 2, mitochondrial
- Non-selective voltage-gated ion channel VDAC1
- Mitofusin-1
- Mitofusin-2
- Pentatricopeptide repeat-containing protein 1
- Sequestosome-1
Sequence:
MALSAQQIPRWFNSVKLRSLINAAQLTKRFTRPARTLLHGFSAQPQISSDNCFLQWGFKTYRTSSLWNSSQSTSSSSQENNSAQSSLLPSMNEQSQKTQNISSFDSELFLEELDELPPLSPMQPISEEEAIQIIADPPLPPASFTLRDYVDHSETLQKLVLLGVDLSKIEKHPEAANLLLRLDFEKDIKQMLLFLKDVGIEDNQLGAFLTKNHAIFSEDLENLKTRVAYLHSKNFSKADVAQMVRKAPFLLNFSVERLDNRLGFFQKELELSVKKTRDLVVRLPRLLTGSLEPVKENMKVYRLELGFKHNEIQHMITRIPKMLTANKMKLTETFDFVHNVMSIPHHIIVKFPQVFNTRLFKVKERHLFLTYLGRAQYDPAKPNYISLDKLVSIPDEIFCEEIAKASVQDFEKFLKTL
Protein: phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Q8SZB2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MWLLREAFFFGLLAMAWAFGDEAIFEDEDIYNQALPPVPHTGITVPGTKWCGPGNTAANFEDLGRERETDKCCRAHDHCDEIIESHGALHGLPTNTDWFPM
Protein: 3-oxo-5-alpha-steroid 4-dehydrogenase (DUF1295) (F4HRY1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGTVLDSHFLALTAIVTVIYQFIFFVITALFKFDQVTDFAGSTNFVILAVLTLVLKASWHFRQIVLTLLVVVWGLRLGIFLLMRILQWGEDRRFDEQRGNIVRLIIFWTLQAVWVWTVSLPLTLVNASDGGGSLKPADVIGWTMWVFGFLIEAAADQQKLSFKNSPENRGKWCDVGVWKYSRHPNYFGEMLLWWGIFVAASPVLEGAEYLVIFGPLFLTLLLLFVSGIPLLEASADKKHGNSGAYRSYKKTTSPLILFPRGVYGNLPGWFKTVFLFEFPFYSRNLPQEGRLQNSKEKEVKDD
Protein: Uncharacterized transporter C36.01c (O59698)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000269|PubMed:10759889}; Multi-pass membrane protein {ECO:0000269|PubMed:10759889}.
Interaction partners:
Sequence:
MSESSVNADTPKNTNDVLNGAYQSATTEPEGQYRSATDNPSLYQVPTHGSLYRNLSNSASAYYPANGNMNSREPANELSDISSLAEKGELEPPMAKLLSDPDFQGKQFPTVEAPELFIFELAPDSPSIALNWTFWRKMKTTSIYAYASLTIAWGSSVLSPASATLAKKYHIGMTTSLLNVSLFMLGYCLGPICWAPMSEITGRKTPLYIGLFLFSVFQIAVATAQDIQTIMICRFFGGYGACVPLCVVAAAFADMYPNRYRGTAITIFAAVIFVGPLVAPIVGGFLTKSYLGWRWTEYITSFMGFLSIILIYLFCEETYLKTITENKVQEYREITGNQLVHARSEEESLSARDIIMNYLLIPLKMLATEPIVFLVSLYCSFVYAIIYLLLEAYPVIFQEGRHFPLGVSALPYIGILVGVFIGCGINCLFEPWYFRQVIKAGNKPAPEARLPPMMIGSFLFPAGIFWLAWSGYYTYVHWIVPTLSGLLTGAGILLIFLQCLNYLLDAYLFRAASVFAANVIMRSAVAGGFPLFAVQMFHNMGVGWAGSLLGFIATALIPMPFAFFFFGKKIRAKSKMTAQF
Protein: Uncharacterized protein (Q583K2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RRM domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MSSFNMQAYPAVGSTAVASFGSPLMDCTNAISNSDNIINGAPRPATMKSSASNVFRGHLRPISTVVEEPVASTRHTHDPYCRTSNDGLPCVPRSPFTAEMSFIMSHSDEGNSHFSNSANSSFSTVPQATNRPLYHQPASRGTTAAAYPTVTINNNNGASSSSSTTTRTGVKQGGFRRAAGGNTAGFGVTPSRAAPAVVSTPVPAAPVVAAAAGGTSVMRVPCKRVYVNGRPVIVSVNEEGQTS
Protein: Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) (Q99KX1)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- ADP-ribosylation factor GTPase-activating protein 2
- Rootletin
- Double C2-like domain-containing protein alpha
Sequence:
MFRFMRDVEPEDPMFLMDPFAIHRQHMSRMLSGGFGYSPFLSITDGNMPATRPASRRMQAGAVSPFGMLGMSGGFMDMFGMMNDMIGNMEHMAAGGNCQTFSSSTVISYSNTGDGAPKVYQETSEMRSAPGGIRETRRTVRDSDSGLEQMSIGHHIRDRAHILQRSRNHRTGDQEERQDYINLDESEAAAFDDEWRRETSRYRQQRPLEFRRHEASVGGGRRAEGPPRLAIQGPEDSPSRQSRRYDW
Protein: Methyltransferase domain-containing protein (Q17539)
Organism: Caenorhabditis elegans
Interaction partners:
- Alpha-tubulin N-acetyltransferase 2
- Regulator of G-protein signaling rgs-5
- SWI/SNF complex subunit SMARCC2
Sequence:
MSAPNEPQSFTDPAYWKNFFAKRKSPFEWYGDYNSLSNVIDKYLKPKDTFLQLGCGNSELATQLYDNGFHCIHSIDVEPSVIATQIRKNKERLGMTFETGDAANLSMADEAHTIVIDKGTLDALLPPSASESDEALVTKMFEEVHRVLASGGRYIIVTLAQPHITEFWINHFYPLKQYILRVQKVENKASGFPMPVFCFIATKMRAPMPNPLPLEVLRSSSIRTDRIDSTDELKDSIRGEQELSQFIYLCSKKLDSEVSIDFHGADPSLGPRYRICVVDNPEAKKIDTFAAFVVPIGRDSEWLFASPKGRKALRVQCGRERLAIVFLNRNQKYEKGMDGVKSDIGHFVGMLDVRQDNTGNYEILSIGGVDVKRTVSTGRSDINGGWSVEEVTVEGNQTRRLVFLNTMNLVQSEAYLKTGKKKQTVIDLDQLACDFHRMMIGSLAISPQQPLAKNDAQCKMAVLGLGGGLLTAYLVRHFKKAHVTAVELDPEVLKIANSHFSFPHSDARIDVVIQDALIHLQETAKKPEEEKYDVIFVDVSGSQNAALQCPPSAFLTPEALGNMKNSVKEQGMISLNLVTRDSEFGKSIKKNIAEYFPTLYTVLSFEDVNEIIIGLKTPKNTIKPVVPQKLINTVRKDIGSYDEVVGAISNIRMVDY
Protein: Cdc42-interacting protein 4, isoform D (M9ND44)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLKKKLAQITKKKTVADLEAECVHSAIAFTCVRVCAKLLASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIFNIFGSNKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSSSSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEITLYA
Protein: Maternal embryonic leucine zipper kinase (MELK) (EC 2.7.11.1) (U4PR86)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants. Plays a role in neural fate specification in several dopaminergic linages, acting in concert with ham-1. Involved in phosphorylation of multiple proteins associated with key developmental processes, including the cell cycle, apoptosis, endocytosis, and asymmetric cell division. Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface. May act downstream of par-4/strd-1/mop-25 to regulate cell shedding.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16774992}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23267054}. Note=Cytoplasmic in undividing cells and co-localizes with centrosome in dividing cells. {ECO:0000269|PubMed:23267054}.
Interaction partners:
- Kinetochore protein ndc-80
- Kinesin-like protein
- Exonuclease 1
- Mitotic spindle assembly checkpoint protein MAD2A
- Kinesin-like protein
- Uncharacterized protein C30G12.6
- Protein ECT2
- Putative pachytene checkpoint protein 2
- Protein regulator of cytokinesis 1
- Forkhead box protein pes-1
Sequence:
MSKYEVLQGFYAVHDELGSGGFGKVRLATHLLTNQKVAIKIIDKKQLGHDLPRVQTEMDALRNLSHQNICRLYHYIETEDKFFIVMEYCSGGEMFDYIVRKERLEESEARHFFRQLVSAIAFVHSQGYAHRDLKPENLLLTEDLHLKLIDFGLCAKTEKGRIDKHNLDTCCGSPAYAAPELIQGLQYKGNEADVWSMGILLYTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDWLNHKYTQPVKWNTIYDKNFIDRDVARVMSKYYGFESTDKMIEKIKEWNFDYMTSTYYALLHRKRNGMEIILPMVRNSTNTAPPNVQNILCSPTIHASLENNLDKSGLEDDDSDPSSISSSSDISARLKKNCVVSDESSSSRFVKPMSPAAEKDKKMSYVNAMLTMPSQFTGRSPLRIPESPMSVRSSDSASLGSAATPSRGGVKDNDKENASTGKNYRMGASTCKSRGPLKITGVEEGTMKSVYTTPNTRPTLRGLFSPGNAEHKKRQRARSSDRASIGMPPGSPVSIGSAHSANNELLADGRTPRSRIKTNRLPQRVFTSLERKKEKLITLLTPRKMQRDSPQVLKDVKNMVNVSMTASQDPEEVRNLLKKVFDDERMRYELNGWKFLATQETVHGWMTVELEIVRLQMFDKVGIRRKRLKGDAFMYKKVCEKILQMAKIE
Protein: DNA polymerase kappa (Q8AWW1)
Organism: Gallus gallus (Chicken)
Interaction partners:
- DNA repair protein REV1
- Proliferating cell nuclear antigen
- Mitotic spindle assembly checkpoint protein MAD2B
- REV3 like, DNA directed polymerase zeta catalytic subunit.
- Uncharacterized protein.
- DNA repair protein RAD51 homolog 1
- DNA polymerase epsilon catalytic subunit
- DNA polymerase eta
- RECA_2 domain-containing protein.
- DNA repair protein complementing XP-A cells homolog
Sequence:
MDNVKNVDKSSYNGGALLRMGLNDNKAGMQGLDKEKINKIIMEASKGSKFYENELKKDQQVNQRIEKMMQLKEKITQQQLLKAQLQVDKLVLELERSRNLSCTIVHIDMDAFYAAVEMRDNPELKEKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKKLCPHLTIVPLNFEKYRKVSKEVKEILAEYDPHFMPMGLDEAYLNVTEHLEERLNWPEDKRRYFLNTENTTEKNKEDINIPGTVNIDGYSSSPELFEDGTSVMDDDSGQRDQSLKNVVVFGTSAEEAVKEIRFRIEQKTQLTASAGIAPNTMLAKMCSDRNKPNGQCRISPERQAVLDFIKDLPIRKVPGIGKVTEKMLKALGIVTCSELYQQRALLSLLFSEASWRSFLDISLGLGSTHLEKDGERKSMSTERTFSEISKAEDQYSLCQELCRELAQDLQKEGLKGKTVTLKLKNVNFEVKTRASTVLSSVSTEDEIFAVAKMLLGTEIDSVAPHPLRIRLMGVRVSGFLSEEEKKYQQKSIKSFLKSGKELDFSRLQPGRSNQENLTKNSEASSRGSFFDKKRAARQLNSNNLFPNESVGKQHFHGVKSSANFVEEANKVTDLQKSNVCEIFTCPVCFEEQSSSNLEEINRHVDECLAGSLVEDTVEISKNDLSRENTFNFLSHCKNENIDDCKENVTDQLAGTGQSASTSENSSGNSRDKKFTQIVSEKPHREKQPGDLIDIPRNASIKQCLSPKRNSQENAVQFGRMDHTEETSSSCSFEAREDSVLVCPVCNLEQKTTSLMSFNRHVDVCLNKGLIQELTEKDDCSAKTSDTENSIRVGGLSRGQKCTKPLQGTKRSGLTTSQSASKKAKSIDSKRTIEMFFK
Protein: Dickkopf-like protein 1 (Protein soggy-1) (SGY-1) (Q9QZL9)
Organism: Mus musculus (Mouse)
Function: Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Subcellular location: Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15892050, ECO:0000269|PubMed:19176879}. Note=Localized specifically to the crescent shaped acrosome at the apex of the sperm head. {ECO:0000269|PubMed:15892050}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
Sequence:
MCRLRVLLLLLPLAFVSSSALPIHDVDSQQNTSGFLGLQRLLQSFSRLFLKNDLLRDLDNFFSSPMDFRDLPRNFHQEENQEHRMGNHTLSSHLQIDKVTDNQTGEVLISEKVEASIEPERNPEGDWKVPKVEAKEPPVPVQKVTDSLHPEPRQVAFWIMKMPRRRTQPDVQDGGRWLIEKRHRMQAIRDGLRGGAREDSLEDGVHIPQHAKLPVRKTHFLYILRPSQQL
Protein: GH07456p (RNA polymerase II p33 subunit) (RNA polymerase II subunit C (EC 2.7.7.6)) (O97183)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Transcription elongation factor SPT4
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase II subunit RPB7
Sequence:
MPYANQPSVQITELTDDNVKFVLEDTELSVANSLRRVFIAETPTLAIDWVQLEANSTVLSDEFLAHRIGLIPLISDDVVERLQYTRDCICLDFCPECSVEFTLDVKCSEEQTRHVTTADLKSSNAKVLPVTSRNQGEEDNEYGESNDEILIIKLRKGQELKLRAYAKKGFGKEHAKWNPTAGVCFEYDPDNSMRHTLYPKPDEWPKSEHTELEDDQYEAPYNWEAKPNKFFFNVESAGALKPENIVVMGVQVLKNKLSNLQTQLSHESQNDALAV
Protein: Protein NDNF (F1QPX0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus. Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling (By similarity). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q8C119}.
Interaction partners:
Sequence:
MTWRCGCYGLVLLVLGVMGQKLPTRDEGLFQMQIRDKAQFHDSSVMPDGAEISGYLFRDTPKRYYFVVEEDNTPLLVTVTPCDAPLEWRLTLQELPEDRSGEGSGEPEPLEQQKQQVTANEGTELFTYKGNDVESFISSSSPSGLYQLEIISTEKDSNFKIYSTTTPESDQPYPELPYDPRVDVTALGRTTVTLAWKPTPTGSVMGQPIQYCVVINKEHNFKSLCAAEAKMSLDDAFMIAPKPGRDFSPFDFAYFGFVPSENDFHKDRFLTTNRALSNKMSRAYIPKPKVADIQKICIGNKNIFTITDLKPDTQYYFDVFAVNTGTNMSTAYVGTFARTKEEAKQKTVELKDGKVTDVFVKRKGSKFLRFAPVSSHQRVTLFVHACLDAVQVQVRRDGKLVLSQNVEGVRQFQLRGKPKAKYLIRLRGSRKGASTLKVLASTRAGGKQPFPALPEDTRIKAFDKLRTCSSVTVAWLGTQERNKYCVYRREVSESYGEEHRRREQNQCSGPESRRKSEKVLCKYFYSANLQKAVTTETITGLEAGKSYLLDVYVVGHSGHSVKYQSKLVKTRKYC
Protein: Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) (Q13163)
Organism: Homo sapiens (Human)
Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
Interaction partners:
- Mitogen-activated protein kinase kinase kinase 2
- Mitogen-activated protein kinase kinase kinase 3
- Mitogen-activated protein kinase 7
- BTB/POZ domain-containing protein 9
- Protein kinase C zeta type
- Sequestosome-1
Sequence:
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP
Protein: Phorbol-12-myristate-13-acetate-induced protein 1 (Protein Noxa) (Q5U777)
Organism: Rattus norvegicus (Rat)
Function: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q13794}.
Interaction partners:
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- Bcl-2-like protein 2
- Bcl-2-like protein 11
- Bcl-2-related protein A1
- Bcl2-interacting killer, isoform CRA_a.
- BH3-interacting domain death agonist
- Glycosylated lysosomal membrane protein
- Cellular tumor antigen p53
- BCL2-antagonist/killer 1, isoform CRA_b.
Sequence:
MPGRKARRNAPLNPTRAELPPEFAAQLRKIGDKVYCTWSAPDITAVLAQMPGKKSRKSTMRRSPSPTRVPADLKDECDQLRRIGDKVNLRQKLLNFISKLFNLIT
Protein: 5-hydroxytryptamine receptor 5A (5-HT-5A) (5-HT5A) (REC17) (Serotonin receptor 5A) (P35364)
Organism: Rattus norvegicus (Rat)
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P47898}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- 5-hydroxytryptamine receptor 5B
- Guanine nucleotide-binding protein G
- Basigin
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- 5-hydroxytryptamine receptor 3A
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MDLPINLTSFSLSTPSTLEPNRSLDTEALRTSQSFLSAFRVLVLTLLGFLAAATFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRARKRVSNVMILLTWALSAVISLAPLLFGWGETYSELSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYKAAKFRMGSRKTNSVSPIPEAVEVKDASQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
Protein: Large ribosomal subunit protein bL31B (50S ribosomal protein L31 type B) (P0A7N1)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Large ribosomal subunit protein bL36B
- Metal-binding protein ZinT
- Large ribosomal subunit protein bL28
- Small ribosomal subunit protein bS16
- Large ribosomal subunit protein bL19
- Large ribosomal subunit protein bL21
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein bL27
- Small ribosomal subunit protein bS20
- Large ribosomal subunit protein bL20
Sequence:
MKPNIHPEYRTVVFHDTSVDEYFKIGSTIKTDREIELDGVTYPYVTIDVSSKSHPFYTGKLRTVASEGNVARFTQRFGRFVSTKKGA
Protein: Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] (P03157)
Organism: Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)
Function: Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid. Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein. Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA). The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
Interaction partners:
Sequence:
MPLSYQHFRKLLLLDDEAGPLEEELPRLADEGLNRRVAEDLNLGNLNVSIPWTHKVGNFTGLYSSTVPVFNPEWQTPSFPHIHLQEDIINRCQQYVGPLTVNEKRRLKLIMPARFYPNLTKYLPLDKGIKPYYPEHAVNHYFKTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELQHGRLVFQTSTRHGDESFCSQSSGILSRSPVGPCVRSQLKQSRLGLQPQQGSMARGKSGRSGSIRARVHPTTRRSFGVEPSGSGHIDNSASSTSSCLHQSAVRKTAYSHLSTSKRQSSSGHAVEFHNIPPSSARSQSEGPIFSCWWLQFRNSKPCSDYCLTHIVNLLEDWGPCTEHGEHNIRIPRTPARVTGGVFLVDKNPHNTTESRLVVDFSQFSRGSTHVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHIPLHPAAMPHLLVGSSGLPRYVARLSSTSRNINHQHGAMQDLHDSCSRNLYVSLLLLYKTFGRKLHLYSHPIILGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLFTSITNFLLSLGIHLNPNKTKRWGYSLNFMGYVIGSWGTLPQEHIVLKLKQCFRKLPVNSPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQSKQAFTFSPTYKAFLCKQYLNLYPVARQRSGLCQVFADATPTGWGLAIGHRRMRGTFVAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGLYRPLLLLPFRPTTGRTSLYAVSPSVPSHLPDRVHFASPLHVAWRPP
Protein: HORMA domain-containing protein (Q95XC8)
Organism: Caenorhabditis elegans
Interaction partners:
- HORMA domain-containing protein
- HORMA domain-containing protein
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Synaptonemal complex protein 3
- Long arms of the bivalent protein 1
- HORMA domain-containing protein
- Meiotic recombination protein rec-8
Sequence:
MAPLENNYNESLNKSKDAIDDKTWSKLFPSIVSDPDRSSNFMIRAIYVVFSAVLRQRNILEKEYFSKNYITENLSCMTLSFKNLRAHQIAQLLRAAGDATKDGFLKEISLVVTEHDGDVEAIEVFSMKFIYFENGGVVARLSTDNNDQEDPHFAELAQLRYEGAESVRDQMVTIVRSVQFLCTKVLEPLPAEFTANFRLKYTNDAPSNFRIDGFDDSSTFYTLPDGIQSVTIGHLRPGHHAAHMQCWSKSMSDSYAAELTLKGHLDKVSDMYAFNPVNVLYKSFNSEDTDPGLSQDTTESANDQGGNVTSPVDNITDSLEKTQMSPIKMRPTTRRGADDSKTRSSPYSRSRK