wanglab/gogpt-training-data huggingface dataset:
Protein: RuvB-like helicase (EC 3.6.4.12) (J7HDV0)
Organism: Plasmodium falciparum (malaria parasite P. falciparum)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
NIIESSREKERISLHSHISGLGLDADGYVTDFLFEENIKKRDMYSEPTNKIENNDIKNGTILDPDKVDNICNSYKLENNGNYENNKICYNNISDDEDEVVKNFYKCKGMVGQKKAREAAGIFINLIKEKNICKCLLLAGPSGSGKTAIAIAISKEISDESIPFCIFNASQVYSCEVKKTEILTQYIRKSIGVKIKEIKEVFEGEVVQIEPFFDNTYDEQKISYVHITLKTLKEQKKIKIHSSIYDNLLKEKIQEKDIIYIESHSGNVKRVGKCSLYQDMFDIETDTFVDLPKGNVHKKKNIIQNITLYDLDVSNVQPKDNILDFLQNNKSKKTEITDKLRNEINKIVYKYVDQGIAQIIPGVLFIDEVHMLDIECFTYLNRTLESNLAPVVILATNRGICNIKGTNIISAHGIPVDLLDRIIIVKTMLYNKEEILQVLKLRCKFERIKIDSEALDYLSDIGIKCSLRYAIQLLTPAKILSKKKGKKKIDKNIIEIVSSIFFDTKRSTQLLLN
Protein: Metacaspase-5 (EC 3.4.22.-) (TbMCA5) (Q8IEW1)
Organism: Trypanosoma brucei brucei
Function: Cysteine protease that cleaves specifically after arginine or lysine residues.
Subcellular location: Recycling endosome {ECO:0000269|PubMed:16507595}. Note=Localizes to RAB11-positive recycling endosomes. {ECO:0000269|PubMed:16507595}.
Interaction partners:
Sequence:
MDAALALLFGQVATAVLPYVVNSIGRVPRPKRVDVKKAMGEAHQCRPVVPYRAPRPYTEGRVKALFIGINYTGSSAQLGGCVNDVMHMLQTLQRIEFPISECCILVDDRRFPNFTAMPTRENIIKYMAWLVYDVRPGDVLFFHFSGHGAETKGGRDSNEKMDQCLVPLDYDKAGAILDDDLFELMIKGLPAGVRMTAVFDCCHSASLLDLPFAFVAGRNVSSNQRHEMRMVRKDNYSRGDVVMFSGCEDSGTSADVTNTSSFGNGTVAAGGAATQAFTWALLNTTGYSYIDIFMKTREVLRQKGYKQVPQLSSSKPVDLYKQFSLFGPLTMNASLVQHLPQEYVQPWAPHPAYQQPHEATLPASVSQPHSQPVMGIPVASTSNGKSNPGVSDGGRASGEVYPPTQYPSSHPAPQQQAYYQPPQQAYYQPPQQAYYQPPQQAYYQPPQQAYYQPPQQAYYQPEPHHQPAPPPPPKKENKPARPGYPMSYCMKFSQGKPGRK
Protein: Alpha-mannosidase D (EC 3.2.1.24) (Q54YC4)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- phosphatidylinositol N-acetylglucosaminyltransferase
Sequence:
MESSKFVKIIWVFGIWILVFTFLIIYNNYDYKSTFGINKFEKRSLKTINQINNKENGDDKKLSVFLIPHSHCDGGWLQDYDGYYYNIVQYILSGVVNELNLDKEKKFNWVEIGFFSRWWNDQNEIQKEIVRNLINNKQLSFISGGWVQNDEATATIDDVITQMTQGHQWLKDTLNYTVEYAWQIDPFGYSSSTPTIFSSMGIKGLVINRVSNDVKSYMKSVKEMEFIWKGSESLGEQSQMLVSTLNIHYDYPKHIDPKKDFSLNDRIKGFTKYLNDLSKTRESNILMIPLGDDFRYSNAKTEFSVSKEWVKALQDNKEYYNIKEIKYATLDEYFIALEDSFLRNNKFGKSRKQNVYTETFSDGDDEVSALSLYNKDFFPYSTGNLEYWTGYYTTRPLLKRLIRESSLLQKSSDILYTLAIGENSNNQIDINNLQTLSNQLNENRNTIALVQHHDIVTGTSRSFVLNDNFQRLQKSRISNYNIISNSLEYLLNKSNNKTNNNNNNNNKNNNNNNNNNNNNNNNLKNTNSISTTGSSSSSGSGSSNNNNNTVNKSEPFNFENAIDLSNESNNQYSLVFHNTLGWEVNQHVSFRIKVNKNDNQLLESIQLVEAISNKTIQIQIIPIQDDSNCQSIENNYIVFAIINLPPLGLNTYYLSIANSEDSKSNFTYLSKPKLLKKGNEINFNNNRFKVEFESNGLISKITDKNSNEIKTIEQTFHQYSTKKSGPYIFNVKGGKKHGFLENPDKFIYHDGPLVSQLTMLYGVDDYCNVTSIVVQRIYKNNNEINNSNSKSLITENYIETGYSINGDMNRETTINYKVKDLENDDIFYTDNGLESRKRIYNHDRSVNQNYYPVLGYIKLKETSENNNHQYTVYVDRSVGATSPSDGEMEIMIHRTMDTDDWKGVNWPSKDIGRSDAKLYFNMDLVNNQLQNEKRISLHITNQPIMFVKKHNNQTGYLLKYSPLSNQLPSNIHLQSLLTLKNNTVGLRLFNIHEVDSNTQSTTDTDKSTLFNELEISNFIETGLSFLKLTKNNLIDKFSTRINKKFPIKCGESEYSFINEKPSSIIFSNNGTNNIIDGENKGENNKTIETIQIKPHEIKSFTFNFNFQLDQIIPNNNNNNNKYAINKELNNEYIEQSIENQRYEYDFSFFPIKPTFYDDRGKYNRPNHLALILSLSIGIPAGILIIVIALVVTYKKRKNRKTLTSSNSSSNLIQQEDQTDYSP
Protein: Protein-lysine N-methyltransferase At1g66680 (EC 2.1.1.-) (Q9C9M1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03188}.
Interaction partners:
- Signal transducer, putative
- Translation initiation factor eIF2 assembly protein
- At3g03150
- PPR superfamily protein
- Pentatricopeptide repeat-containing protein At3g20730
- Pentatricopeptide repeat-containing protein At4g31070
- U-box domain-containing protein 8
- AT4g21620/F17L22_80
- Uncharacterized protein F28B23.5
- Transmembrane protein
Sequence:
MAGIRLLPEEPETTPQQQARAAAAVTTTTTDSLASDDDRSIAADSWSIKSEYGSTLDDDQRHADAAEALSSANFRVSSDYSSDKEEPDADGGGQSMLGLQSYWDAAYSDELTNFREHGHAGEVWFGDDVMEIVTSWTKDLCVEISQRNMSVSENDVTTEVNDQADKYLSSWNVLDLGTGNGLLLHQLAKEGFSDLTGTDYSDGAVELAQHLSQRDGFPNIRFMVDDILDTKLEQQFKLVMDKGTLDAIGLHPDGPVKRVMYWDSVSKLVAPGGILVITSCNHTKDELVEEVENFNIRKSNLCRGDGNDANNVLSSGSEAASRIDQPPFEYLSHVRTYPTFMFSGSVGSRVATVAFLRK
Protein: Bone morphogenetic protein receptor, type IBb (EC 2.7.11.30) (Zgc:172219 protein) (A8WG63)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MELRVRTGNEKFWTLILLGVLWIYSSAHANVLDTMLQRSSGKVTAGRKETNGGSATSVIPERMLLCHCYHHCPEDSTNNTCRTDGYCFTMAEEEEGGSPVLTSGCLSLVGSEFQCRDTGNARLRRILECCTDQDYCNQDLHPTLPPLKTPG
Protein: Actin cytoskeleton-regulatory complex protein END3 (Endocytosis protein 3) (P39013)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. END3 regulates PAN1 function by preventing phosphorylation of PAN1 by PKR1 and is also involved in the correct localization of SLA1 to the cell cortex, in the bipolar budding of diploid cells and the correct distribution of chitin at the cell surface.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Interaction partners:
- Actin cytoskeleton-regulatory complex protein PAN1
- Actin cytoskeleton-regulatory complex protein SLA1
- Protein SLA2
- Proline-rich protein LAS17
- Epsin-1
- Epsin-2
- Clathrin heavy chain
- Clathrin light chain
- Clathrin coat assembly protein AP180A
- Actin
Sequence:
MPKLEQFEIKKYWQIFSGLKPIENKVNHDQVLPILYNSKLDSSVLNKIWFLADIDDDDNLDFEEFVICMRLIFDMVNKNISSVPDELPDWLIPGSKVNLIKERKKRKQIENADLPPKKEIKVDWYMSPDDLNQYEKIYNSCAKLTDGTITFNELSTKLSTKFFNISKTDLNKVWSLINPQNLPSIDRDPTFYFIHCLRQRNDLGAEIPASLPNSLAEVCNKKQLSYDLRSSQPPTKRKEEANEVDNLRDNGQNSSSDSSGSNVLSNEDSIKQKYASLTDDQVANMREQLEGLLNYKKSEKTQGGSKLSKRINIRSITDDLDNIEQQVEVLENYLNNKRHELQALQAEIN
Protein: Amino acid transporter, putative (Q57WK4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MTNQSSGGNDRGRRDTDPFAHAGDVKLSSDAIALDVTQKGQDDVVKEVKPSLFTVLLEKFIPHGGLWSCALNLASATLGAGICSLPTGFNLSGIVMSCIYLVCVAVGTVYSLNLLAKVAVKTGSRNYGEAARMVMGPLAGYYAAALMIAMCFGGNVAYIIIIGIILRALFSRDGVPEYLKSESGNRLMTSMVWLVIILPMCIPKQVNSLRHLSFVGVMFIVYFSCVVIGHSINKIINEGVADGIVYMRTGNSALDGLSLFLFSFICQSNAFEIFREMKHRSPQRFTIYGTVGMSMCAVLYFLVGLFGYLEFGGDAIDTVLSLYDPGENVAVAIAYIGVAAKVCVAFALHIIPMRDALYHCTGWHVDTVPYWKHSLIVTSITLAALLVGLFIPKASTVFGLVGAFCGGHIGLVLPPLFYMYSGGFTREKVGNIDFFGTYLLLFVGVVAVVLGTGSAVYYAV
Protein: Probable sigma-70 factor, ECF subfamily (Q9HUR7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable transmembrane sensor
- Sigma factor regulator, FemR
- Secretin/TonB short N-terminal domain-containing protein
- Probable transmembrane sensor
- Probable transmembrane sensor
- Probable transmembrane sensor
- Probable transmembrane sensor
- Probable sigma-70 factor, ECF subfamily
- Ferric-mycobactin receptor, FemA
- Sensor protein PfeS
Sequence:
MNAPSSCLSADRDGVATLYRENHAWLRNWLAYRLRSWGRGVADDLAHDTFLRILASRDGGQREAIRQPRAYLTRIANCVLVSWRRRQSLELAWLEALATLPEPLQPSPEQQSVIVETLHEIDALLDTLRPRVKQAFLMATLDGMKQKDIAQALGVALPTVKKFIHQAYVTCLSLMPDE
Protein: NAD(+) kinase (EC 2.7.1.23) (Q5FVF8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEMEQEKMNLSKELNPDSASYNCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTIMHIQDPASQRLTWNKSPKSVLVIKKIRDASLLQPFKELCIYLMEENNMIVYVEKKVLEDPAIVGDENFGPVKKKFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQPGDATWSPHPQGSVPPVMAFHLGSLGFLTPFNFENFQSQVNQVIEGNAAVILRSRLKVRVVKEPRDKKTAIHNGLSENGLDTEGGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMVHPNVPAIMVTPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVCDPVSDWFESLAQCLHWNVRKKQAHFPEDEEDQDEEDS
Protein: Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma) (P28705)
Organism: Mus musculus (Mouse)
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P48443}. Cytoplasm {ECO:0000250|UniProtKB:P48443}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma
- Retinoic acid receptor beta
- Retinoic acid receptor alpha
- Retinoic acid receptor gamma
- Retinoic acid receptor RXR-beta
- Nuclear receptor coactivator 2
- Nuclear receptor coactivator 1
- Retinoic acid receptor RXR-alpha
- Paired box protein Pax-8
- Peroxisome proliferator-activated receptor delta
Sequence:
MYGNYSHFMKFPTGFGGSPGHTGSTSMSPSVALPTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECASSSHEDMPVERILEAELAVEPKTESYGDMNVENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDSFLMEMLETPLQIT
Protein: Nuclear pore complex protein An-Pom152 (Eurofung) (C8VHB2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Nuclear pore complex protein An-Ndc1
- Nuclear pore complex protein An-Nup188
- Nuclear pore complex protein An-Nic96
- Nuclear pore complex protein An-Nup170
Sequence:
MSDTPRLRSAFPSTPQTTQKTRDYNRSPSRPIPRNAPRSKVVSQAPSADQDASSSLVPSSIIDPPTQRLYVAAAYVALNAWRFYEAWTASDDLDSTWLFLKWASIDGVFLFGLQALRIPWLEWAFPTTLALLLVHVAFNIFLMFRIPIPVGIWLSGMMRLAYDRELSISGQSIKPGDIINNASLILGKQIINILPEGSAVLNPELAPLCLDAQKTAVELPIRVNQTDPILIELLRLDFNNGDSEIVTIQSKQLKQLKRQSDKRRSQLSSELHRDLLLPIRKTGIYRLQRVVDESKLEVRVRASDSIVTACPRALIKNSHTHKCRGELSNLVLAVEGTPPLKIKYSRQVNDHDRGFSFQNIQPDHLRTPLLGHRSLGRLFDGREPDITWAKSQIIEIPLNESLNIGGDWLYMIEEVHDGSGNVANYSMVLEDLDRQSVKSLAQWHHFSVHEIPKLSLSGCNDQQFLEVARGESHPLPVKFHSTDHGYENDGPFSLIYSFGTDGQGSVDDSARTVRQLSLKSVDQKPMIKEPGWYSLKYVSSQFCSGEILEPSSCYLHNPPEPEISVRSEKIFDKCANNPVGLLVDLDLTGSPPFRLRYTIETSKGVETKHQIIDGLRAQLDFTPLEAGHYRYRFLDISDSVYGPRPLENKVAVLEQDVKPPASANFVGTPEVRKACFGEPISVDVAFHGEAPWTLQYELVHNGKKTRHVLESETARSTIITDNLVSGGGYNLVLTSVKDRSKCKRNLNEILKVDARSKPPHVSFGLVEKSRKYSALQGSKVDIPIRLSGERPWTLQYKNLDADASISTKTFWHENSFLTVSQEGRYELLGVTDSSCPGSVDDAAKVFEISWIPRPQITAVDNTPVGPDGLVAKNDICQGQGDSLELRLTGNPPYTIQCEQQRKGSRGSTAVRIRSLKTALHSLSMELETSEPGDYTYRFKEVGDNLYNNDPRGNQVVVTQKVNPLPSARFDAPGRIYGFCREDDSGDELIPLTMEGVPPFFLEISIKHYAKAKPEIVSIPNIKSNRHNLPIPRRHLDLGQHVVSIHKVRDARGCEKTYHTDPASVRVAVSDVPTIVPLESKTDYCVGERLSFSLSGHSPFEVFYTFNGVARRASSQTNHFRRIAEKPGVFTITAVSDGASGKCKAHKDIVKTIHPMPSVRISNGQVSIVDIHEGGEAKLEFEFWGTPPFEFTYIRSTNARKGKKAEIIDIKHDISYEHHKIIKTSDEGTYEVVAIKDKYCSFSTQPSMEKNEKLLTNS
Protein: Type VI secretion system tip protein VgrG (A0A0H2VBP9)
Organism: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Interaction partners:
- ImpA N-terminal domain-containing protein
- Type VI secretion protein VasK
- Type VI secretion system baseplate subunit TssF
- IraD/Gp25-like domain-containing protein
- Type VI secretion lipoprotein
- PAAR domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- ClpB protein
- Type VI secretion protein
Sequence:
MEALMNVQFFDHAHHKLKIRGLQSPVDVLTFEGREQLSTPFRYDIQFTSSDKAIAPESVLMQDGAFSLTAPPVQGMPVQTALRTLHGVITGFKHLSSSQDEARYEVRLEPRMALLTRSRQNAIYQNQTVPQIVEKILRERHQMRGQDFVFNLKSEYPAREQVMQYGEDDLTFVSRLLSEVGIWFRFATDARLKIEVIEFYDDQSGYERGLTLPLRHPSGLFDGETEAVWGLNTAYSVVEKSVSTRDYNYREATAEMTTGQHDATGGDNTTYGEAYHYADNFLQQGDKEAAESGAFYARIRHERYLNEQAILKGQSTSSLLMPGLEIKVQGDDAPAVFRKGVLITGVTTSAARDRSYELTFTAIPYSERYGYRPALIPRPVMAGTLPARVTSTVKNDIYAHIDKDGRYRVNLDFDRDTWKPGYESLWVRQSRPYAGDTYGLHLPLLAGTEVSIAFEEGNPDRPYIAGVKHDSAHTDHVTIQNYKRNVLRTPANNKIRLDDERGKEHIKVSTEYGGKSQLNLGHLVDAGKEQRGEGFELRTDLWGAVRAKKGIFISADAQDKAQGQVLEMQPALARLSAALVTMESLAASAQQAQALAADVSRQQTLLQQKIEQLQQEVLLGSAPKGVALVSGEDMQLSASDNLTLTAGKQLDIGVQKDFTLAAGKQLSLYSRAGAKLFSSHNDIDIQAQGGNLTTWSTQDTYISSGKKLVVTAQDELTLICGGGYIKIKSGNVEIGGPGKLLVKNAGIKKAGSGSMQGVMKSFEPESFDENFIISNPASGKPIANQKYEIHMPDGSVIAGITDAMGYSSLVASKASDDLKIILKK
Protein: Brevinin-1Ecb (P86150)
Organism: Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
FLPLLAGLAANFFPKIFCKITRKC
Protein: Secreted chorismate mutase (CM) (EC 5.4.99.5) (A0QU81)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P9WIB9}.
Interaction partners:
- Chorismate synthase
- Prephenate dehydrogenase
- Intracellular chorismate mutase
- Prephenate dehydratase
- Cyclohexadienyl dehydratase
- Anthranilate synthase component 1
- isochorismate synthase
- Anthranilate synthase component 2
- Anthranilate synthase component I
- Phospho-2-dehydro-3-deoxyheptonate aldolase AroG
Sequence:
MLASVALAALAGVGTPHATADDASPLVPLVDAAAQRLQTADPVAASKFRSGGAIDDPDREQQVIAAVTGDATRHNIDPGYVHDVFRNQIDATSSVEHTRFAQWKLDPAAAPSSAPDLSESRQKIDTLNRTMVDEIARQWPVLHSPVCRPDLDRALDAVATARGFDPVYRHALEYATHSYCR
Protein: Metabotropic glutamate receptor 1 (mGluR1) (P97772)
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q13255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13255}. Postsynaptic cell membrane {ECO:0000269|PubMed:27276689}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:33488348}. Note=Located in dendrioles, small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell. {ECO:0000269|PubMed:33488348}.
Interaction partners:
- Metabotropic glutamate receptor 5
- Homer protein homolog 1
- Guanine nucleotide-binding protein G
- Homer protein homolog 2
- Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- Spectrin beta chain
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Guanine nucleotide-binding protein subunit alpha-11
- Gamma-aminobutyric acid type B receptor subunit 1
- Guanine nucleotide-binding protein G
Sequence:
MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGYVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPITIRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSTHFSPPSSPSMVVHRRGPPVATTPPLPPHLSAEETPLFLADSVIPKGLPPPLPQQQQQPPPQPPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNGLRSLYPPPPPPQHLQMLPLQLSTFREEPISPPGEDDDDDSSERFKLLQEFVYEREGNTEEDDLEEEEDLPAASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL
Protein: Protein Isd11 (PfIsd11) (Q8IEK7)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24086138}.
Interaction partners:
- Cysteine desulfurase IscS
- Iron-sulfur cluster assembly protein IscU
Sequence:
MNGNQIKQLKKLYRHILNEASKFENINYNVYFSNKAKEKFREFCSDTNFESEKLKTFQNECWDYLNMLKRQTIIHNLYHVDKPLVNK
Protein: Protein LTV1 homolog (Q96GA3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:34999892}. Note=The protein is expressed in a diffuse cytoplasmic pattern with granular perinuclear accentuation within the basal keratinocytes. {ECO:0000269|PubMed:34999892}.
Interaction partners:
- Bystin
- Small ribosomal subunit protein uS5
- Serine/threonine-protein kinase RIO1
- RNA-binding protein NOB1
- Serine/threonine-protein kinase RIO2
- Small ribosomal subunit protein uS3
- Pre-rRNA-processing protein TSR1 homolog
- RNA-binding protein PNO1
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS19
Sequence:
MPHRKKKPFIEKKKAVSFHLVHRSQRDPLAADESAPQRVLLPTQKIDNEERRAEQRKYGVFFDDDYDYLQHLKEPSGPSELIPSSTFSAHNRREEKEETLVIPSTGIKLPSSVFASEFEEDVGLLNKAAPVSGPRLDFDPDIVAALDDDFDFDDPDNLLEDDFILQANKATGEEEGMDIQKSENEDDSEWEDVDDEKGDSNDDYDSAGLLSDEDCMSVPGKTHRAIADHLFWSEETKSRFTEYSMTSSVMRRNEQLTLHDERFEKFYEQYDDDEIGALDNAELEGSIQVDSNRLQEVLNDYYKEKAENCVKLNTLEPLEDQDLPMNELDESEEEEMITVVLEEAKEKWDCESICSTYSNLYNHPQLIKYQPKPKQIRISSKTGIPLNVLPKKGLTAKQTERIQMINGSDLPKVSTQPRSKNESKEDKRARKQAIKEERKERRVEKKANKLAFKLEKRRQEKELLNLKKNVEGLKL
Protein: Nodulation receptor kinase (EC 2.7.11.1) (Does not make infections protein 2) (MtSYMRK) (Symbiosis receptor-like kinase) (Q8L4H4)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Involved in the perception of symbiotic fungi and bacteria. Part of the perception/transduction system leading to nodulation or mycorrhizal infection. Phosphorylates PUB1.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MMELQVIRIFRLVVAFVLCLCIFIRSASSATKGFESIACCADSNYTDPKTTLTYTTDHIWFSDKRSCRQIPEILFSHRSNKNVRKFEIYEGKRCYNLPTVKDQVYLIRGIFPFDSLNSSFYVSIGVTELGELRSSRLEDLEIEGVFRATKDYIDFCLLKEDVNPFISQIELRPLPEEYLHGFGTSVLKLISRNNLGDTNDDIRFPDDQNDRIWKRKETSTPTSALPLSFNVSNVDLKDSVTPPLQVLQTALTHPERLEFVHDGLETDDYEYSVFLHFLELNGTVRAGQRVFDIYLNNEIKKEKFDVLAGGSKNSYTALNISANGSLNITLVKASGSEFGPLLNAYEILQARSWIEETNQKDLEVIQKMREELLLHNQENEALESWSGDPCMIFPWKGITCDDSTGSSIITKLDLSSNNLKGAIPSIVTKMTNLQILNLSHNQFDMLFPSFPPSSLLISLDLSYNDLSGWLPESIISLPHLKSLYFGCNPSMSDEDTTKLNSSLINTDYGRCKAKKPKFGQVFVIGAITSGSLLITLAVGILFFCRYRHKSITLEGFGKTYPMATNIIFSLPSKDDFFIKSVSVKPFTLEYIEQATEQYKTLIGEGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGREPLNIKRPRIEWSLVEWAKPYIRASKVDEIVDPGIKGGYHAEALWRVVEVALQCLEPYSTYRPCMVDIVRELEDALIIENNASEYMKSIDSLGGSNRYSIVMDKRALPSTTSTAESTITTQTLSHPQPR
Protein: Rrp41p homologue (Q95Z13)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MPVIKEYINPAGLRLDGRRQNEPRRLALEFGKISGCDGCCTVVSGLSHVCATVYGPREVSNRLDGKYNEVTITCDVVVAAFAGERRREQQRYSRLSEDISASVLDVARSVVLLSQYPNSQIHICIEVLKQDGSDKAACINAACLALIDASIAMRDVVYTQTVGLIEGFDVVDLTTEEIHSQCPSICITVQGHDPTNIVWMESNSRLAPEVITRLVKVAQKASTDVFETALRGPLEEHAATVLRLQANLGNIE
Protein: Sodium channel neurotoxin MeuNaTxalpha-1 (P86408)
Organism: Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Function: Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin inhibits inactivation of Nav1.6/SCN8A (EC(50)=3.1 uM) and drosophila DmNav1 (EC(50)=1.17 uM). It also shows a weak inhibition of inactivation on Nav1.2/SCN2A Nav1.3/SCN3A, and Nav1.7/SCN9A. The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels. The toxin has also been shown to dose-dependently stimulates intracellular signaling in DRG neurons through activation of two kinases (type II protein kinase A (PKA-II) and MAP kinases 1/3 (MAPK1/MAPK3)). Nav1.2/SCN2A is strongly suggested to be the target channel predominantly involved in this activation. In vivo, the toxin induces a dose-dependent thermal hyperalgesia lasting 30-45 minutes.
Subcellular location: Secreted {ECO:0000269|PubMed:21969612}.
Interaction partners:
Sequence:
MNSLVMISLALLVMTGVESVRDGYIADDKNCAYFCGRNAYCDEECKKKGAESGYCQWAGQYGNACWCYKLPDKVPIKVSGKCNGR
Protein: Uncharacterized transporter C11D3.18C (Q10097)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative hydro-lyase C5H10.01
- Probable peptide transporter ptr2
- Uncharacterized protein C11D3.15
Sequence:
MSDQSEYKISKDDEHSIYASEINKEKLQNTASPDVDYGDTASLKIDPKVEKKLLLKMDLVISPIIGFLYLMAFLDRSNIGNAAVAGMTEALSLYGERLNVAVSIFYVLYILVETPSVVLVKRIKASRMLAFISFAWSMTVLFSGFMSSYGGLIATRLILGLLEGCLFPALNLYLTTHYTRKEQCQRLSYLFASAGLAGAFGGLFAYALEQVHAGNKEGWQWIYIVEGLVSFIGVPLCLFALPDKMENAWFLTREEREVAIIRRDINARYHGEQHFEWSEVRKAFKDPKVYVSATSQFCADMVLYGFSSFLPVIIKGLGFVGLQTNYMTIPVYIAGVISFLFVAWLSDRTQLRAVYLISASTVVAVGYIIMLASDSNAAKYTATYIIAIGCYIGPGLNLGWLNNNVAGHYKRATAIGIQQTLANSSGIVAGQIYRSKNAPKYILGNAFTLGCVIVGGLAYVVMFFSLRYVNKKRDERCARGEFDPSAIGDFADDFRYYL
Protein: Lipase (Q9VKT8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSLSSSSKFLIWTFFLGLFQLEANAFFNPFQLAIPSSVLEDAHLNTIQLISKYGYPAENYTVQSDDGYLLGLFRIARPGALPVLLVHGLMDSSDTWVMMGPSSSLGYMLYEQGYDVWMANVRGNTYTKRHVRYSAEDSDFWNFSFHEMGIFDLPAIIDYILMQSGFGQLHYIGHSQGSTIFWILASERPEYMEKIVMMQALAPVAFLSHCRSPIVNLLASQDTAVASFLSAAGYNEFLPSNSVIDQFKRYACRDIISSSVCQSLFFILFGFNGQQVNQTMLPIVVGHTPAGASIRQMHHYGQLRNSGKFQQFDYGLLNFLHYGSLSPPPYELEKVKAKVAIYYAKNDWIAPPEDVDMLFNRLPNVVEKYLVPNENFNHFDLVWGRDAKRILWNRMLGVMQSVVPYSSYNDGDSITTVFVNRF
Protein: Putative pentatricopeptide repeat-containing protein At3g05240 (Q9MA95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Phosphoglycerate mutase family protein
Sequence:
MMKKHYKPILSQLENCRSLVELNQLHGLMIKSSVIRNVIPLSRLIDFCTTCPETMNLSYARSVFESIDCPSVYIWNSMIRGYSNSPNPDKALIFYQEMLRKGYSPDYFTFPYVLKACSGLRDIQFGSCVHGFVVKTGFEVNMYVSTCLLHMYMCCGEVNYGLRVFEDIPQWNVVAWGSLISGFVNNNRFSDAIEAFREMQSNGVKANETIMVDLLVACGRCKDIVTGKWFHGFLQGLGFDPYFQSKVGFNVILATSLIDMYAKCGDLRTARYLFDGMPERTLVSWNSIITGYSQNGDAEEALCMFLDMLDLGIAPDKVTFLSVIRASMIQGCSQLGQSIHAYVSKTGFVKDAAIVCALVNMYAKTGDAESAKKAFEDLEKKDTIAWTVVIIGLASHGHGNEALSIFQRMQEKGNATPDGITYLGVLYACSHIGLVEEGQRYFAEMRDLHGLEPTVEHYGCMVDILSRAGRFEEAERLVKTMPVKPNVNIWGALLNGCDIHENLELTDRIRSMVAEPEELGSGIYVLLSNIYAKAGRWADVKLIRESMKSKRVDKVLGHSSVETMF
Protein: C-X-C chemokine receptor type 4b (Chemokine (C-X-C motif), receptor 4b) (Chemokine receptor CXCR4) (Cxcr4B) (Q9PTF7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early endosome {ECO:0000256|ARBA:ARBA00004412}.
Interaction partners:
- Stromal cell-derived factor 1
- Stromal cell-derived factor 1
- G-protein alpha 12 alpha 12) alpha 12a)
- Guanine nucleotide-binding protein
- G-protein alpha 13a, alpha 13a)
- Chemokine
- Macrophage migration inhibitory factor
- Beta-arrestin-1
- Arrb2b protein
- Arrestin, beta 2a.
Sequence:
MEFYDSIILDNSSDSGSGDYDGEELCDLSVSNDFQKIFLPTVYGIIFVLGIIGNGLVVLVMGFQKKSKNMTDKYRLHLSIADLLFVLTLPFWAVDAVSGWHFGGFLCVTVNMIYTLNLYSSVLILAFISLDRYLAVVRATNSQNLRKLLAGRVIYIGVWLPATFFTIPDLVFAKIHNSSMGTICELTYPQEANVIWKAVFRFQHIIIGFLLPGLIILTCYCIIISKLSKNSKGQTLKRKALKTTVILILCFFICWLPYCAGILVDALTMLNVISHSCFLEQGLEKWIFFTEALAYFHCCLNPILYAFLGVRFSKSARNALSISSRSSHKMLTKKRGPISSVSTESESSSALTS