wanglab/gogpt-training-data huggingface dataset:
Protein: Spectrin beta chain (Q6XD99)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAESYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLLLSQDYGKHLLGVEDLLQKHALVEADIAIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERISYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSNDVGHDEYSTQSLVKKHKDVAEEISNYRPTIDTLHEQAGALPQAHAESPDVKGRLAGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIRAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNREAASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTTSAQNKVLDGASVFLLMYSCPPRCWRIRWKRGRAQMRVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIITDSSSLNAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHKAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHMADDLINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACEGRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTACIELGKALLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSAKVSEEAESQQWDTSKGDQVSQNGLPAEQGSPRMAGTMETSEMVNGAAEQRTSSKESSPVPSPTSDRKAKSALPAQSAATLPARTLETPAAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKSAASGVPYHSEVPVSLKEAICEVALDYKKKKHVFKLRLSDGNEYLFQAKDDDEMNTWIQAITSAISSDKHDTSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKKK
Protein: Trans-2-decenoyl-[acyl-carrier-protein] isomerase (EC 5.3.3.14) (Q8DR19)
Organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Function: Catalyzes the isomerization of trans-2-decenoyl-ACP to cis-3-decenoyl-ACP. Most active with 10-carbon enoyl-ACP. Can also use 12-carbon enoyl-ACP as substrate, but not 14- and 16-carbon enoyl-ACP.
Interaction partners:
- Probable nitronate monooxygenase
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- HTH marR-type domain-containing protein
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Malonyl CoA-acyl carrier protein transacylase
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein uS2
- Beta-ketoacyl-[acyl-carrier-protein] synthase III
- Large ribosomal subunit protein uL3
Sequence:
MEHIIYQLEEDLAILTLNRPEVANGFHIPMCEEILEALTLAEENPAVHFILINANGKVFSVGGDLVEMKRAVDEDDIPSLTKIAELVNTISYKIKQIAKPVLMEVDGAVAGAAANMAVAADFCLATDKAKFIQAFVGVGLAPDAGGIHLLSRSIGVTRAAQLAMTGEALTAEKALEWGLVYRVSEAEKLEKTREQLLKKLRRASSNSYAAIKKLVWESQFKDWQGYATLELNLQKSLAQTEDFKEGVRAHSERRRPKFIGK
Protein: Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Adenosine 5'-monophosphoramidase FHIT) (EC 3.9.1.-) (Adenylylsulfatase) (EC 3.6.2.1) (Adenylylsulfate-ammonia adenylyltransferase) (EC 2.7.7.51) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein) (Q9JIX3)
Organism: Rattus norvegicus (Rat)
Function: Possesses dinucleoside triphosphate hydrolase activity (By similarity). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (By similarity). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (By similarity). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (By similarity). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (By similarity). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (By similarity). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (By similarity). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (By similarity). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (By similarity). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity) Functions as tumor suppressor (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P49789}. Nucleus {ECO:0000250|UniProtKB:P49789}. Mitochondrion {ECO:0000250|UniProtKB:P49789}.
Interaction partners:
Sequence:
MSFKFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLMCPLRPVERFRDLRPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQTVKHVHVHILPRKSGDFRRNDNIYDELQKHDREEEDSPAFWRSEEEMAAEAEVLRAYFQA
Protein: DUF6787 domain-containing protein (Q387Y9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYRLMVPHKTAKWASASAPRAFRNAFRRCSTQEGEAAAASRTGKSTVGDTSAGCQQTGPQRKDWRTGKEVVYVKGVPVKGPLRKLPRKEQILVCVIFSITGSAAVYFVRPVIRNCVTNGFLGLPEDSSWSNGPWLYRLLYVSIMYPSYSFLLFVIGSLFGRRVWFSFMIHKMWSRFLPKKAAKRLKHMLDLQHY
Protein: Protein PHYTOCHROME KINASE SUBSTRATE 3 (Q8GXS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably involved in the phytochrome signaling pathway.
Interaction partners:
- Root phototropism protein 3
- Auxin transporter-like protein 1
- Protein PHYTOCHROME KINASE SUBSTRATE 4
Sequence:
MDAEKKSAHFRQISSYKPQLLVLSSIQENPSSKISEKANIKADNDAEIGVFGAEKYFSMKLDHVDSTADITKQHEKENTHDHPNANPNPNPNPHPHPHPQLTKTTSSRSKTSRHGTPSVRSESSCNSQTFLMRINNHNENKQRKMNDTSISFGGFRCYGPCSGVKTVHTDPKNSCKSRNSDRDFVAYDARKHNDKPRLHFEAKKADFHAQEKISLPIQRSDIAMNLERKLSLLTWDAIPNQLSTKNNNHNNNGNNSSMSSNTQEEETASVASSDLFEIENITSSVYEPSEASIGWSVVTGSMADQSVISDFDMMKRVTRNGPVVKTKPVIGEKVRSAGFLSGCKSHKAVSVVDSSRKVKETAKVDHHEMSHQKKFKTEIRIQDLSFL
Protein: Transcription factor AmrZ (G8Q5R9)
Organism: Pseudomonas ogarae (strain DSM 112162 / CECT 30235 / F113)
Function: Functions as both a transcriptional activator and repressor of multiple genes encoding virulence factors as well as genes involved in environmental adaptation. Represses genes involved in iron homeostasis. Modulates intracellular levels of c-di-GMP which in turn regulates swimming motility and biofilm formation.
Interaction partners:
Sequence:
MRPLKQAIYSSRTADKFVVRLPDGMRERIAEVARNHHRSMNSEIIARLEQSLIQEGALGEELSMRLDSPELSLHERELLQRFRQLSHRQQNALVSLIAHDAEMAADAT
Protein: Notochord granular surface (Zgc:194470) (B3DI58)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Lactosylceramide alpha-2,3-sialyltransferase
Sequence:
MNECEDTITRFCFRTTGINMSYSPERMSSYRRHFEGGLAASSTLQVRVSSPSPTRGATRHRSASYSRSTGRRALSGTRKSRMTSSVSMGTLCLGMGFGGAGGAVDLDAAAAENQAFLSTRTSERKEMIALNDRLAVYIEKVRSLEQSNKLLETEIDAIKGHHVKPSGLRLLYEEQLREMKKIADQMKIQRDLAVAAKDAMAGQLEMLKVKYEEALEARKKAELEIEAFRPDVDAATSARIALEKRLENLEVELEFLQRIHKKEIEELMAQIYGSVAKVDVAFSLPDLASALKQIQAQYDSIAAQNLQDMDAWYKGKFQDLNNVSSRHMETARSAREEIMGYKKEMQNKQRELDALKNRNEALLLMIKEAQENYRKEEEELHTRIETLKEELRSIKGKIALLLREYQDLLNVKMSLEIEITTYRKLIEGEDSRLSSMVGGLSLMGGSVSSGLVSSVSAYSSAAAAAAAVSSAASEKMISSNSTLNHNHHESVEEFTHEQAVEMTERKTVLIRTVKTDEDTIQKDTEERTITISGAADEDE
Protein: Uncharacterized protein C8E11.05c (O42882)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MASPPILSRESPVLGLEEEKKSDGGNSEVNIDPSASSSLKEDVDGEEGADTKIDPHLLEEDDLNPVEDYDSKNQKVVEASKLDLDATSTVWAESLSINREASISQSGIVDNEMEKKVEEEEEFDEFDDFGEFEHDIPICTFMGDWQDDFQDAVNSVFGLPETPKTIEESSLDPDRILSLWQKLIEMPVLQRPDWLRSSIRHIFLVTMGLPVDLDELLPTPSTQGSFNSSRTIELSSVTLPKSEDEPYLDYSAARRLCSINKDALTHRSHESLQQHIELLESTLQQAVEVARYWTDKRDSALSDKLLYETVVDDLVQHSKRLRNSGRKFLSRRSTSSHK
Protein: Uncharacterized protein Rv3633 (P9WI89)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible conserved membrane protein
- Possible transferase
- Uncharacterized protein Rv3630
- Probable conserved integral membrane protein
- Conserved protein
Sequence:
MTQSSSVERLVGEIDEFGYTVVEDVLDADSVAAYLADTRRLERELPTVIANSTTVVKGLARPGHVPVDRVDHDWVRIDNLLLHGTRYEALPVHPKLLPVIEGVLGRDCLLSWCMTSNQLPGAVAQRLHCDDEMYPLPRPHQPLLCNALIALCDFTADNGATQVVPGSHRWPERPSPPYPEGKPVEINAGDALIWNGSLWHTAAANRTDAPRPALTINFCVGFVRQQVNQQLSIPRELVRCFEPRLQELIGYGLYAGKMGRIDWRPPADYLDADRHPFLDAVADRLQTSVRL
Protein: Zinc finger CCCH domain-containing protein 56 (AtC3H56) (Q9LXV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Zinc finger CCCH domain-containing protein 46
- Zinc finger CCCH domain-containing protein 62
- Zinc finger CCCH domain-containing protein 28
- Zinc finger CCCH domain-containing protein 51
- Zinc finger CCCH domain-containing protein 55
- Zinc finger CCCH domain-containing protein 59
- Zinc finger CCCH domain-containing protein 1
- Zinc finger CCCH domain-containing protein 12
- Zinc finger CCCH domain-containing protein 15
- Splicing factor U2af small subunit B
Sequence:
MCGLAKKLDIEDTLTSLSDQENESLAKPMNDAAEWEHSFSALLEFAADNDVEGFRRQLSDVSCINQMGLWYRRQRFVRRMVLEQRTPLMVASLYGSLDVVKFILSFPEAELNLSCGPDKSTALHCAASGASVNSLDVVKLLLSVGADPNIPDAHGNRPVDVLVVSPHAPGLRTILEEILKKDEIISEDLHASSSSLGSSFRSLSSSPDNGSSLLSLDSVSSPTKPHGTDVTFASEKKEYPIDPSLPDIKSGIYSTDEFRMFSFKIRPCSRAYSHDWTECPFAHPGENARRRDPRKFHYTCVPCPDFKKGSCKQGDMCEYAHGVFECWLHPAQYRTRLCKDGMGCNRRVCFFAHANEELRPLYPSTGSGLPSPRASSAVSASTMDMASVLNMLPGSPSAAQHSFTPPISPSGNGSMPHSSMGWPQQNIPALNLPGSNIQLSRLRSSLNARDIPSEQLSMLHEFEMQRQLAGDMHSPRFMNHSARPKTLNPSNLEELFSAEVASPRFSDQLAVSSVLSPSHKSALLNQLQNNKQSMLSPIKTNLMSSPKNVEQHSLLQQASSPRGGEPISPMNARMKQQLHSRSLSSRDFGSSLPRDLMPTDSGSPLSPWSSWDQTHGSKVDWSVQSDELGRLRKSHSLANNPNREADVSWAQQMLKDSSSPRNGNRVVNMNGARPLTQGGSSVNPHNSDTRESDILDAWLEQLHLDR
Protein: Patellin-3 (Q56Z59)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carrier protein that may be involved in membrane-trafficking events associated with cell plate formation during cytokinesis. Binds to some hydrophobic molecules such as phosphoinositides and promotes their transfer between the different cellular sites (By similarity).
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Mainly membrane-associated. Also cytoplasmic (By similarity). {ECO:0000250}.
Interaction partners:
- Ankyrin repeat-containing protein At5g02620
- AT1G14820 protein
- UNC93-like protein 1
- Protein PLASTID MOVEMENT IMPAIRED 1
- SEC14 cytosolic factor family protein / phosphoglyceride transfer family protein
- AT3g10210/F14P13_19
- Transmembrane protein
- Defensin-like protein 199
- MD-2-related lipid recognition domain-containing protein / ML domain-containing protein
- Sec14p-like phosphatidylinositol transfer family protein
Sequence:
MAEEPTTTTLVTPEKLPSPSLTPSEVSESTQDALPTETETLEKVTETNPPETADTTTKPEEETAAEHHPPTVTETETASTEKQEVKDEASQKEVAEEKKSMIPQNLGSFKEESSKLSDLSNSEKKSLDELKHLVREALDNHQFTNTPEEVKIWGIPLLEDDRSDVVLLKFLRAREFKVKDSFAMLKNTIKWRKEFKIDELVEEDLVDDLDKVVFMHGHDREGHPVCYNVYGEFQNKELYNKTFSDEEKRKHFLRTRIQFLERSIRKLDFSSGGVSTIFQVNDMKNSPGLGKKELRSATKQAVELLQDNYPEFVFKQAFINVPWWYLVFYTVIGPFMTPRSKSKLVFAGPSRSAETLFKYISPEQVPVQYGGLSVDPCDCNPDFSLEDSASEITVKPGTKQTVEIIIYEKCELVWEIRVTGWEVSYKAEFVPEEKDAYTVVIQKPRKMRPSDEPVLTHSFKVNELGKVLLTVDNPTSKKKKLVYRFNVKPL
Protein: ABC transporter F family member 5 (ABC transporter ABCF.5) (AtABCF5) (GCN20-type ATP-binding cassette protein GCN5) (Q9LV93)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 50S ribosomal protein L33
- Large ribosomal subunit protein bL31c
- Large ribosomal subunit protein bL28c
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- ABC transporter E family member 3
- 50S ribosomal protein L20
- Large ribosomal subunit protein bL20c
- Large ribosomal subunit protein bL27c
- AT5g15220/F8M21_110
- Large ribosomal subunit protein bL21c
Sequence:
MGLSTNLHSLDLRSTFFTGLRTSPIPSNFIKISSISNPRRDISTIRAQVSTISLETSVKQRQDEIESLFSKQPSQQDSDRKRNGKSSKNGASGISSGVKLENIRKSYKGVTVLKDVTWEVKRGEKVGLVGVNGAGKTTQLRIITGQEEPDSGNVIKAKPNMKVAFLSQEFEVSMSKTVREEFMTAFKEEMEITEKLEKVQKAIEGSVDDLDLMGRLLDEFDLLQRRAQAVNLDSVDAKISKLMPELGFAPEDADRLVASFSGGWQMRMSLGKILLQDPDLLLLDEPTNHLDLDTIEWLEGYLQKQDVPMVIISHDRAFLDQLCTKIVETEMGVSRTFEGNYSQYVISKAEWIETQNAAWEKQQKDIDSTKDLIARLGAGANSGRASTAEKKLEKLQEQELIEKPFQRKQMKIRFPERGTSGRSVVNVKNIDFGFEDKMLFKKANLSIERGEKIAILGPNGCGKSTLLKLIMGLEKPVKGEVILGEHNVLPNYFEQNQAEVLDLDKTVLETVCEAAEDWRSDDIKGLLGRCNFKADMLDRKVSLLSGGEKARLAFCKFMVTPSTLLVLDEPTNHLDIPSKEMLEEAINEYQGTVIAVSHDRYFIKQIVNRVIEVEDGCLEDYAGDYNYYLEKNLDARTKELEREAELEEKAPKVKAKSKMSKAEKEARKKQKMQAFQQAKQKSKASKNSKRWN
Protein: Endoglucanase (EC 3.2.1.4) (Carboxymethylcellulase) (CMCase) (Cellulase) (Endo-1,4-beta-glucanase) (P37651)
Organism: Escherichia coli (strain K12)
Function: Hydrolyzes carboxymethylcellulose.
Subcellular location: Secreted.
Interaction partners:
- Cellulose synthase catalytic subunit
- Cyclic di-GMP-binding protein
- Cellulose synthase operon protein C
- Periplasmic beta-glucosidase
- Cyclic di-GMP binding protein BcsE
- Cellulose biosynthesis protein BcsG
- HTH-type transcriptional regulator ChbR
- Cellulose biosynthesis protein BcsF
- PTS system N,N'-diacetylchitobiose-specific EIIA component
- PTS system N,N'-diacetylchitobiose-specific EIIC component
Sequence:
MNVLRSGIVTMLLLAAFSVQAACTWPAWEQFKKDYISQEGRVIDPSDARKITTSEGQSYGMFSALAANDRAAFDNILDWTQNNLAQGSLKERLPAWLWGKKENSKWEVLDSNSASDGDVWMAWSLLEAGRLWKEQRYTDIGSALLKRIAREEVVTVPGLGSMLLPGKVGFAEDNSWRFNPSYLPPTLAQYFTRFGAPWTTLRETNQRLLLETAPKGFSPDWVRYEKDKGWQLKAEKTLISSYDAIRVYMWVGMMPDSDPQKARMLNRFKPMATFTEKNGYPPEKVDVATGKAQGKGPVGFSAAMLPFLQNRDAQAVQRQRVADNFPGSDAYYNYVLTLFGQGWDQHRFRFSTKGELLPDWGQECANSH
Protein: Soluble N-ethylmaleimide sensitive factor (NSF) attachment protein (Q381H8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Vesicle transport v-SNARE N-terminal domain-containing protein
- Syntaxin 5
- t-SNARE coiled-coil homology domain-containing protein
- Target SNARE, putative
- Gamma-soluble NSF attachment protein
- Golgi SNARE protein-like
- SNARE protein, putative
- Vesicle-associated membrane protein, putative
- Vesicle-fusing ATPase
- Sec1 family transport protein, putative
Sequence:
MSKPPEQLVAEAEKLLHKGWLSFLGSGSNYEKAHEKLVSAGTQYKAAGDFANAARVFERAAELCKKDKNEVDFIVDLEEAARCHAKAGDVKAATRLYEQIVDTYDRKRQNVKAAKACLSLSELLGSNERAVEWLDRATKYYEAQGSHTMAADVLKSMAEQMIKGGNYEGALMMYDRLARKALDDRAARLGARNLFFMALLSQLSTLTSENVSVGVESVRERFTEYQELDPQFNEYTREHMLITAIIEAMECESPEKLKEAIDDYSTVCTVNDIKEQIFARAVKLLEGRSESIM
Protein: NAC-alpha domain-containing protein 1 (O15069)
Organism: Homo sapiens (Human)
Function: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor BTF3
- Transcription factor BTF3 homolog 4
- Elongation factor 1-gamma
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein eS8
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL20
Sequence:
MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM
Protein: Lipid A 4'-phosphatase (EC 3.1.-.-) (Q9ZJ31)
Organism: Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Function: Removes the 4'-phosphate group from tetra- and hexaacylated lipid A species, has no 1-phosphatase or Kdo hydrolase activity. Absence of the 4'-phosphate group renders the bacteria resistant to host-derived cationic antimicrobial peptides (CAMP), allowing it to camouflage itself from the host innate immune response, and plays a critical role in the long-term colonization of the host's stomach.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:A0Q4N6}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKKLKGLFLSLLLWVYPLKSEPINEGAYILEEIGDVLRFLPIFVGTVSLAMRDYRGLGELAVGTLVTQGVIYGLKGAFSTAHKDGARVGFAKRPCCNSWRGMPSGHAGGAFSAAGFVYYRYGWKPALPVIALAILTDTSRVVAGQHTILQVTIGSLIAWGFAYLFTSRYKPKRWMLYPEISSDFKGSSRYGVGFSYQW
Protein: Elongator complex protein 4 (A0A1W2PNY5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAVATCGSVAASTGSAVATASKSNVTSFQRRGPRASVTNDSGPRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQNKAIIARVTTLSDVVVGLESFIGSERETNPLYKDYHGLIHIRQIPRLNNLICDESDVKDLAFKLKRKLFTIEVDFIS
Protein: E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (KChAP) (Potassium channel-associated protein) (Protein inhibitor of activated STAT protein 3) (O70260)
Organism: Rattus norvegicus (Rat)
Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1. Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O54714}. Nucleus {ECO:0000269|PubMed:9565597}. Nucleus speckle {ECO:0000250|UniProtKB:O54714}. Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. {ECO:0000250|UniProtKB:O54714}.
Interaction partners:
- Signal transducer and activator of transcription 3
- Signal transducer and activator of transcription 1
- Small ubiquitin-related modifier 1
- SUMO-conjugating enzyme UBC9
- Small ubiquitin-related modifier
- Small ubiquitin-related modifier
- Signal transducer and activator of transcription 5A
- Signal transducer and activator of transcription
- Signal transducer and activator of transcription
- Transcription factor p65
Sequence:
MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPSPLASIPPTLLTPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQEGNQSENKKRVEVIDLTIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMGTLGSDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYSPSVITSLDEQDTLGHFFQFRGTPPHFLGPLAPTLGSSHRSATPAPAPGRVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDVISLD
Protein: Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) (P25208)
Organism: Homo sapiens (Human)
Function: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Subcellular location: Nucleus.
Interaction partners:
- Nuclear transcription factor Y subunit alpha
- Nuclear transcription factor Y subunit gamma
- DNA-binding protein REPIN1
- MHC class II transactivator
- Chromatin accessibility complex protein 1
- Inhibitor of growth protein 2
- Histone acetyltransferase p300
- CCAAT/enhancer-binding protein zeta
- Huntingtin-associated protein 1
- Speedy protein C
Sequence:
MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQISGVQQIQFS
Protein: Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (P27889)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Pterin-4-alpha-carbinolamine dehydratase
- Hepatocyte nuclear factor 6
- Histone lysine acetyltransferase CREBBP
- Hepatocyte nuclear factor 4-alpha
- Hepatocyte nuclear factor 3-beta
Sequence:
MVSKLTSLQQELLSALLSSGVTKEVLIQALEELLPSPNFGVKLETLPLSPGSGADLDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQNQGPGQSEDTCSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHNLNPLLTHGSPHHQPSSSPPNKMSGVRYNQPGNNEVTSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHSLLSPDSKMQITVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQGVPVINSVASSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSINTLTSMSSSKQCPLQAW