wanglab/gogpt-training-data huggingface dataset:
Protein: CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) (P51948)
Organism: Homo sapiens (Human)
Function: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Subcellular location: Nucleus.
Interaction partners:
- General transcription factor IIH subunit 1
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIH subunit 2
- General transcription factor IIH subunit 4
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- Cyclin-dependent kinase 7
- Cyclin-H
- General transcription factor IIH subunit 3
- Transcription initiation factor IIE subunit beta
- General transcription factor IIE subunit 1
Sequence:
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS
Protein: Apoptosis-associated speck-like protein containing a CARD (PYD and CARD domain-containing protein) (Q9I9N6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa-dependent apoptosis. Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines. Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death (By similarity). The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Clustered PYCARD nucleates the formation of caspase-1 filaments through the interaction of their respective CARD domains, acting as a platform for of caspase-1 polymerization (By similarity). Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12464617, ECO:0000269|PubMed:30150286}. Inflammasome {ECO:0000269|PubMed:29791979, ECO:0000269|PubMed:30150286}. Note=Co-localizes with nlrp1, caspa and caspb in the cytoplasm (PubMed:30150286). Co-localizes with caspa and caspb independently at large cytoplasmic aggregates, known as specks (PubMed:12464617, PubMed:29791979, PubMed:30150286). {ECO:0000269|PubMed:12464617, ECO:0000269|PubMed:29791979, ECO:0000269|PubMed:30150286}.
Interaction partners:
- Caspase a
- Caspase b,-like
- Caspase b
- Caspase 8, apoptosis-related cysteine peptidase
- Caspase 22, apoptosis-related cysteine peptidase
- NACHT, LRR and PYD domains-containing protein 1 homolog
- Si:ch211-196h16.4.
- NACHT domain-containing protein.
- Interleukin-1.
- CARD- and ANK-domain containing inflammasome adapter protein
Sequence:
MAESFKEHLQEAFEDLGADNLRKFKSKLGDRRQEPRVTKSAIEKLKDEIDLADLMVGVFTSKDAVSVTVEILRAIKCNAVADDLLRNTGQSESKGALSDESKCASSKAVSKVAFSKVNFIDEHWKELIDRVNNVDPILDILRQKKVITNEDYCTIRNKETPQKKMRELLTGPITCAGNKGKEVLYDALRESNKFLMDDLEDAE
Protein: (S)-3,5-dihydroxyphenylglycine transaminase (EC 2.6.1.103) (p-hydroxyphenylglycine transaminase) (O52815)
Organism: Amycolatopsis orientalis (Nocardia orientalis)
Function: Catalyzes the transamination of p-hydroxybenzoylformate to L-p-hydroxyphenylglycine as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin, a member of the vancomycin group of antibiotics.
Interaction partners:
- 4-hydroxymandelate oxidase
- 4-hydroxymandelate synthase
- 
- Aminotransferase
- 4-hydroxyphenylpyruvate dioxygenase
- Protein mbtH
- Antibiotic synthesis protein MbtH
- Protein mbtH
- Protein mbtH
- GntR family transcriptional regulator
Sequence:
MEILVFMDSYGLSTQLSMETLHGSLTDPAISSMNLLNELIDEYPVAISMAAGRPYEEFFDVRLIHEYIDAYCDHLRHDRKLAEAVVTRTLFQYGTTKGIIADLIARNLAEDENIDAAAESVVVTVGAQEAMFLILRTLRADERDVLLAPAPTYVGLTGAALLTDTPVWPVQSTANGVDPEDLVLQLKRADEQGKRVRACYVTPNFANPTGTSMDLPARHRLLEVAEANGILLLEDNAYGLFGSERLPSLKSLDRSGNVVYIGSFAKTGMPGARVGYVVADQRVAGGGLLADQLSKLKGMLTVNTSPIAQAVIAGKLLLNDFSLTKANAREIAIYQRNLQLTLSELERTLGGLPEVGWNTPTGGFFVTVTVPFVVDDELLAHAARDHGVLFTPMHHFYGGKDGFNQLRLSISLLTPELIKEGVTRLAALITARLRWPRA
Protein: RRM domain-containing protein (Q55GV1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MNNNQNMNRNYNNNQNNSNNNTNNNGNSNQNNMGMNMNMNMNMNMNMNNNNNMNGMGGGNNMMMNNGMNNFNNSSNSFMYNNNNTNMNGMNNMNMNNFNGYNNNNNNNNNYNGSNNMNGGNNNNNNNNMNNHNNNNINNNNNYNNNNNNNNNKKVILPKNFTNHDGPILIKDNNGKVIGEKEKLGRTLFVRNVAYSIKEVDIPAIFAKIGEIKKTFSLLESRGIAFISYYDLRDAERAKNEIQGTTLDGRSIDIHFSIPKEESGLEDNAGFIHVKNRDVPLNEVRIFFSSYGDIKDVTEFNRDQVLVEFYDLRACEKALAEANGVKLGDQTLDLDYYTPKEIPAIIDAYEGRKQNNNNSNNSNNNNRGGMNNRNNYNRRDNNNNNNNNNNNDDSDNRKRNNMGGNFNNNNRGMDFNKSGPIRNVYQTDRNPDYRRRDDNNYNNSNSNNNNSRKYTDSGDKSYKSNQNNYSNSVNNYNNNNNNNNSNNNNNNNNNSHNNMNQNSYYNDNSGGGIYNNMNSNFNSNNNNNNNNSGSNSNTNGGWNNNNSNSNNMNNMNMNNNMNNNMNNNMNNNMNNNMNNNMNNMNKNMNNNNNNMNNNNNNNNMNNSNNMGYGNSNNSNYNFNYNNISNPSNNFNNNNYNNSFINYSEPSFPNDGASPEILANISQLAQTLKIPFQWNANNISSNVQNK
Protein: Wall-associated receptor kinase-like 10 (EC 2.7.11.-) (Q8VYA3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Guanylyl cyclase 1
- At3g48450 family protein)
- Defensin-like protein 259
Sequence:
MSSNCSCSLLSLFSLLLIIDLTVASSCPKTCGGIDIPYPFGIGTGCYLEKWYEIICVNNSVPFLSIINREVVSISFSDMYRRFFNVGYGSIRIRNPIASKGCSSGGQEFGSLLNMTGYPFYLGDNNMLIAVGCNNTASLTNVEPSIVGCESTCSTNQDIPINDYLGVLYCNARYGDSEYCKNISIMNDTSCNGIGCCKASLPARYQQIIGVEIDDSNTESKGCKVAFITDEEYFLSNGSDPERLHANGYDTVDLRWFIHTANHSFIGSLGCKSIDEYTILRRDNREYGIGCLCDYNSTTTGYATCSCASGFEGNPYIPGECKDINECVRGIDGNPVCTAGKCVNLLGGYTCEYTNHRPLVIGLSTSFSTLVFIGGIYWLYKFIRRQRRLNQKKKFFKRNGGLLLQQQLTTTEGNVDSTRVFNSRELEKATENFSLTRILGEGGQGTVYKGMLVDGRIVAVKKSKVVDEDKLEEFINEVVILSQINHRNIVKLLGCCLETDVPILVYEFIPNGNLFEHLHDDSDDYTMTTWEVRLRIAVDIAGALSYLHSAASSPIYHRDIKSTNIMLDEKHRAKVSDFGTSRTVTVDHTHLTTVVSGTVGYMDPEYFQSSQFTDKSDVYSFGVVLAELITGEKSVSFLRSQEYRTLATYFTLAMKENRLSDIIDARIRDGCKLNQVTAAAKIARKCLNMKGRKRPSMRQVSMELEKIRSYSEDMQPYEYASENEEEKKETLVDVNVESRNYVSVTAASSQYSIATTSSSRSDVEPLFPR
Protein: Kinase D-interacting substrate 220 (A0A1Y7VMH7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MIAAEQGNVEIVKELIKNGANCNLEDLDNWTALISASKEGHIHIVEELLKCGANLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHIEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGARVSAVDKKGDTPLHVAIRGRSRRLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLILLLCGGLGLVFAFTVDTNLAIAVSLSFLALLYIFFIVIYFGGRQEGESWNWAWALSTRLARHIGYLELLFKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKTEDSQGKKKWKKTCCLPSFIIFLFIVGCIIAGITLLAIFRVDPKHLTVNAILISIASIVGLAFVLNCRTWWQVLDSLLNSQRKRLHSAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDISCSEATGVQEDADRRVSQNSLGEMTKLGSKTALNRRDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQITFNWDRLASWINLTEQWPYRTSWLILYLGETEGIPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKTFLPCTVNLDPKLREIIADVRAAREQINIGGLAYPPLPLHEAPPRPPSGYSQPASVCSSSASFNGPFPGGVVSPQPHSSYYSGLSGPQHPFYNRASVPATGTSLLLSSMTVDIVCEKLRQIEGLDQGMLPQYCTTIKKANINGRVLAQCNIDELKKEMAMNFGDWHLFRSMVLEMRSVENQVVPEDPRFLNENSSAPVAHGESARRTSHSELPHTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGTGSSTISGRSSPHSTYYIGQSSSGGSIHSNLEQERGKENELKQEEGRKSFLMKRGDVLDYSSSGVSTNEASPLDPITEEDEKSDQSGSKLLPGKKSSERPSLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDKKAEGKAERVAKSPEHSVEPIRTFIKAKEYLSDALLDKKDSSDSGVRSNESSPNHSLHNEAADDSQLEKANLIELEDEGHSGKRGMPHSLSGLQDPVIARMSICSEDKKSPSECSLIASSPEESWPSCQKAYNLNRTPSTVTLNNNTAPTNRANQNFDEIEGVRETSQVILRPGPSPNPTAVQNENLKSMAHKRSQRSSYTRLSKDASELHAASSDSTGFGEERESIL
Protein: Transketolase, chloroplastic (TK) (EC 2.2.1.1) (Q7SIC9)
Organism: Zea mays (Maize)
Function: Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}.
Interaction partners:
- Aldolase-type TIM barrel family protein
- Aldolase-type TIM barrel family protein
- Ketose-bisphosphate aldolase class-II family protein
- transaldolase
- Aldolase superfamily protein
- Ribulose-phosphate 3-epimerase
- Photosystem II stability/assembly factor
- ribulose-phosphate 3-epimerase
- ribulose-phosphate 3-epimerase
- Carbamoyl phosphate synthase arginine-specific large chain, chloroplastic
Sequence:
GAVETLQGKAATGELLEKSVNTIRFLAIDAVEKANSGHPGLPMGCAPMGHVLYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLQYALLHLAGYDSVKEEDLKQFRQWGSRTPGHPENFETPGVEVTTGPLGQGIANAVGLALAEKHLAARFNKPDSEIVDHYTYVILGDGCQMEGIANEACSLAGHWGLGKLIAFYDDNHISIDGDTEIAFTEDVSTRFEALGWHTIWVKNGNTGYDDIRAAIKEAKAVTDKPTLIKVTTTIGFGSPNKANSYSVHGSALGAKEVEATRQNLGWPYDTFFVPEDVKSHWSRHTPEGAALEADWNAKFAEYEKKYADDAATLKSIITGELPTGWVDALPKYTPESPGDATRNLSQQCLNALANVVPGLIGGSADLASSNMTLLKMFGDFQKDTAEERNVRFGVREHGMGAICNGIALHSPGFVPYCATFFVFTDYMRGAMRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEHLVSFRAMPNILMLRPADGNETAGAYKVAVLNRKRPSILALSRQKLPHLPGTSIEGVEKGGYTISDNSTGNKPDLIVMGTGSELEIAAKAADELRKEGKTVRVVSFVSWELFDEQSDEYKESVLPAAVTARISIEAGSTLGWQKYVGAQGKAIGIDKFGASAPAGTIYKEYGITVESIIAAAKSF
Protein: RhCG1-b (Rhcg1-a) (A8QJ81)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ammonium transporter AmtB-like domain-containing protein
Sequence:
MGCIQSFRQCCDRPKNTYVRISLPAVCFVWQIAMIILFGIFIRYNEESDAHWIEHKTFNNISSNIENDFYFRYPSFQDVHVMIFVGFGFLMTFLKRYSFGAVGFNFLIAGFGLQWALLMQGWFHSLDPMDGKIKIGVESMINADFCVASCLIAYGAVLGKVSPVQLMVMTLFGVTLYAVEEYIILSLIHARDAGGSMVIHTFGAYYGLSISWMLYRPNLDQSKHRIGSVYHSDVFAMIGTLFLWMFWPSFNSAISDHGDGQHRAAINTYLSLAATVLTSIAISSLSQKTGKLDMVHIQNATLAGGVAVGTAAEFMLMPYGSLIVGFCCGIISTLGYIYITPFMEKHLKIHDTCGIHNLHAMPGVIGGIVGAITAAAASKGVYGKEGLTNTFDFDGKWKDMLPTQQGGHQAAGLCVALCFGIGGGIIVGCILRLPIWGDAPDNSCFDDDIYWELPEDEENNPPTVEYNNHMRNKAVTESNISLERRQN
Protein: Protein inhibitor of activated STAT, 4 (B5DFF9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus, nuclear body {ECO:0000256|ARBA:ARBA00034306}.
Interaction partners:
- Small ubiquitin-related modifier 1
- Small ubiquitin-related modifier 3
- Small ubiquitin-related modifier
- Small ubiquitin-related modifier 2
- Cellular tumor antigen p53
- Protein kinase C zeta type
- NF-kappa-B essential modulator
- Serine-protein kinase ATM
- SUMO-conjugating enzyme UBC9
- Signal transducer and activator of transcription 3
Sequence:
MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKSAEPGPQAPRPLDPLALHSMPRTPLSGPTVDYPVLYGKYLNGLGRLPTKALKPEVRLVKLPFFNMLDELLKPTELVPQSAEKLQESPCIFALTPRQVEMIRNSRELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMYLSSATNRITVTWGNYGKSYSVALYLVRQLTSSDLLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLIIDGLLSKILSECEDADEIEFLAEGSWRPIRAEKEPSCSPQGPILVLGTSDANGLAPASSTPGMGSGLSGPGGAGGGAGAAGGLENGKTGADVVDLTLDSSSSSEDEDEDEDDDEDDDEGPRPKRRCPFQKGLVPAC
Protein: Plasma membrane proteolipid 3 (P87284)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in the regulation of membrane potential. Could mediate a proton leak.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein SNA2
- Protein SNA4
- Protein HOR7
- Plasma membrane ATPase proteolipid 2
- Plasma membrane ATPase proteolipid 1
- Cytochrome c oxidase subunit 9, mitochondrial
- Protein SNA3
- Mitochondrial import receptor subunit TOM5
- Putative uncharacterized protein YDR193W
- ATP synthase subunit J, mitochondrial
Sequence:
MDSAKIINIILSLFLPPVAVFLARGWGTDCIVDIILTILAWFPGMLYALYIVLQD
Protein: Est1p (A0A1D8PP89)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- UPF3 domain-containing protein
- Telomerase reverse transcriptase
- Telomere replication protein EST3
- Cdc13p
- ATP-dependent RNA helicase
- ATP-dependent DNA helicase II subunit 2
- C2H2-type domain-containing protein
- 5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein
- Nuclear cap-binding protein complex subunit 1
- Nuclear cap-binding protein subunit 2
Sequence:
MFAGSVCVIYKSVTTKKNFFLFLFTNSYALAMAYTDEIQLYKTKLDDILAKKYIDQSLLVGFTASLQAKFYGWIVADLDRYHHNLGLPFRTIDLFETLWADFHSPIIKFFQHQHAVVFEEINNNLKECQREGKPGSFKVKPVEMRKINDSFIKFIKDVFGFYSKLLKYFVTHYRNSYLPKKFMESFNFTVEKSAVYCADDNFQANVLYLVHRCCLSLGDIHRHRTFIETSFVTPASSNREYFRIRSSTDKTFLFPAYSKALQYYHLCIMLLPALNEPYNHIGVIYNLVDEKFTAVYWFLRSQFTRIPDYKLGLANLTKLLQKHWFTTALVDIVKSTPERRFSNTRIMNVYLVCLIGYIYCPEKYKSGPNIVKKISFSKIETDFFKMLDKNFEEEVVLQQLVVAFSFLKLDGQEKLVKFTFRFVERVLGCLKTQESLVILRFLLNVLRENQEFLKVFQSRKKCVVYLCAVLNKYYQEVSHRPTRAYYFWEDVHFRDFSLIKYQFKDFRDDGIFEANDIDVLVGDYAGDRSNENDLRAKAVLVLGKKILGGAEGYEVKEADKLSIKRRDQAVVVPQSLEEIQSLISNQAKELCMDIDQGMQNMVDKLVEDDPIW
Protein: DNA-packaging protein FI (P03709)
Organism: Escherichia phage lambda (Bacteriophage lambda)
Function: Stimulates the interaction of procapsid with the terminase-DNA complex, thereby increasing the overall rate of DNA packaging. Before packaging, it likely coats the surface of the procapsid through binding mediated by C-terminal domain. FI presumably dissociates from the capsid once it inflates upon DNA packaging, and is not present in the mature virion.
Subcellular location: Host cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MTKDELIARLRSLGEQLNRDVSLTGTKEELALRVAELKEELDDTDETAGQDTPLSRENVLTGHENEVGSAQPDTVILDTSELVTVVALVKLHTDALHATRDEPVAFVLPGTAFRVSAGVAAEMTERGLARMQ
Protein: Diphthamide biosynthesis protein 3 (CSL-type zinc finger-containing protein 2) (DelGEF-interacting protein 1) (DelGIP1) (Q96FX2)
Organism: Homo sapiens (Human)
Function: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14980502}. Nucleus {ECO:0000269|PubMed:14980502}.
Interaction partners:
- Secretion-regulating guanine nucleotide exchange factor
- 2-
- 2-
- Elongation factor 2
- Elongator complex protein 3
- DnaJ homolog subfamily C member 24
- Diphthine methyl ester synthase
- Diphthine methyltransferase
- Diphthine--ammonia ligase
- Protein KTI12 homolog
Sequence:
MAVFHDEVEIEDFQYDEDSETYFYPCPCGDNFSITKEDLENGEDVATCPSCSLIIKVIYDKDQFVCGETVPAPSANKELVKC
Protein: Protein tilB (Touch insensitive larva B protein) (Q9VR52)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cilium-specific protein required for cilia structures in Johnston's sensory organ. Plays a role in motility of cilia and flagella.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20215474}. Cell projection, dendrite {ECO:0000269|PubMed:20215474}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:20215474}. Note=Detected in the inner and outer dendritic segment and basal body.
Interaction partners:
- Zinc finger MYND domain-containing protein 10 homolog
- Dynein heavy chain
- Dynein axonemal assembly factor 3 homolog
- Dynein axonemal assembly factor 5
- Uncharacterized protein, isoform B
- Putative inner dynein arm light chain, axonemal
Sequence:
MVLITEELVRKKSEHNERLISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERVENLEGCESLSKLDLTLNFIRELTSVESLCGNYNLRELVLIGNPCVDYPHYRDYVVATLPQLNSLDCVEITPSERLRALRELSKNRSIIVQKQVEQDIERDEQRIRVAKQQSALAEHCAGIEDEEERIKAFWQAKSEHCPEIRTEIARQHRLGRERHETKSPLDPLKPQRNLFAPCGRPYNLNQAKLPFKFRDEADHYLLQLEVYRHLDTSLIDVDVQTTYTRVTVKKKIFQIAYSEEVKPDESTVQRSQITGHLVVNLKKLKVNELLIAKKSPTKSPAAPFDAGKKDGKPEEAFHGGVVDISNICAPEDLPDLI
Protein: Glucan 1,4-alpha-glucosidase SusB (EC 3.2.1.3) (Alpha-glucosidase SusB) (Glucoamylase SusB) (Starch-utilization system protein B) (G8JZS4)
Organism: Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
Function: Glucoamylase that hydrolyzes alpha-1,4-glucosidic linkages, alpha-1,6-, alpha-1,3- and alpha-1,2-glucosidic linkages during starch degradation.
Subcellular location: Periplasm {ECO:0000305|PubMed:8955399}.
Interaction partners:
- Alpha-amylase SusG
- Pullulanase
- Retaining alpha-galactosidase
- Neopullulanase SusA
- Alpha-glucosidase
- Alpha-glucosidase
- Alpha-glucosidase, putative
- Starch-binding protein SusD
- Alpha-glucosidase, putative
- Alpha-glucosidase
Sequence:
MKKRKILSLIAFLCISFIANAQQKLTSPDNNLVMTFQVDSKGAPTYELTYKNKVVIKPSTLGLELKKEDNTRTDFDWVDRRDLTKLDSKTNLYDGFEVKDTQTATFDETWQPVWGEEKEIRNHYNELAVTLYQPMNDRSIVIRFRLFNDGLGFRYEFPQQKSLNYFVIKEEHSQFGMNGDHIAFWIPGDYDTQEYDYTISRLSEIRGLMKEAITPNSSQTPFSQTGVQTALMMKTDDGLYINLHEAALVDYSCMHLNLDDKNMVFESWLTPDAKGDKGYMQTPCNTPWRTIIVSDDARNILASRITLNLNEPCKIADAASWVKPVKYIGVWWDMITGKGSWAYTDELTSVKLGETDYSKTKPNGKHSANTANVKRYIDFAAAHGFDAVLVEGWNEGWEDWFGNSKDYVFDFVTPYPDFDVKEIHRYAARKGIKMMMHHETSASVRNYERHMDKAYQFMADNGYNSVKSGYVGNIIPRGEHHYGQWMNNHYLYAVKKAADYKIMVNAHEATRPTGICRTYPNLIGNESARGTEYESFGGNKVYHTTILPFTRLVGGPMDYTPGIFETHCNKMNPANNSQVRSTIARQLALYVTMYSPLQMAADIPENYERFMDAFQFIKDVALDWDETNYLEAEPGEYITIARKAKDTDDWYVGCTAGENGHTSKLVFDFLTPGKQYIATVYADAKDADWKENPQAYTIKKGILTNKSKLNLHAANGGGYAISIKEVKDKSEAKGLKRL
Protein: Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4) (Protein FAM77A) (Q9JMG4)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGFCSGRCTLLALCALQLVTALERQVFDFLGYQWAPILANFTHIIVVILGLFGTIQYRPRYIVVYVVWAAVWVTWNVFIICFYLEVGGLSKDSELLTFNLSGHRSWWEEHGPGCLHEEEATAGLGALHGQSLVVGAGCAMVHSYVEALHSGLQILLALLGFVYGCYVVSVLTEEEDSFDFIGGFDPFPLYHVNEKPSSLLSKQAYLPA
Protein: Galactose/methyl galactoside import ATP-binding protein MglA (EC 7.5.2.11) (P0AAG8)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable).
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01717, ECO:0000305|PubMed:6294056}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01717, ECO:0000305|PubMed:6294056}.
Interaction partners:
- D-galactose/methyl-galactoside binding periplasmic protein MglB
- Galactose/methyl galactoside import permease protein MglC
- Probable ABC transporter permease protein YphD
- Ribose import permease protein RbsC
- L-arabinose transport system permease protein AraH
- Autoinducer 2 import system permease protein LsrC
- D-allose transport system permease protein AlsC
- HTH-type transcriptional regulator GalS
- Autoinducer 2 import system permease protein LsrD
- Xylose transport system permease protein XylH
Sequence:
MVSSTTPSSGEYLLEMSGINKSFPGVKALDNVNLKVRPHSIHALMGENGAGKSTLLKCLFGIYQKDSGTILFQGKEIDFHSAKEALENGISMVHQELNLVLQRSVMDNMWLGRYPTKGMFVDQDKMYRETKAIFDELDIDIDPRARVGTLSVSQMQMIEIAKAFSYNAKIVIMDEPTSSLTEKEVNHLFTIIRKLKERGCGIVYISHKMEEIFQLCDEVTVLRDGQWIATEPLAGLTMDKIIAMMVGRSLNQRFPDKENKPGEVILEVRNLTSLRQPSIRDVSFDLHKGEILGIAGLVGAKRTDIVETLFGIREKSAGTITLHGKQINNHNANEAINHGFALVTEERRSTGIYAYLDIGFNSLISNIRNYKNKVGLLDNSRMKSDTQWVIDSMRVKTPGHRTQIGSLSGGNQQKVIIGRWLLTQPEILMLDEPTRGIDVGAKFEIYQLIAELAKKGKGIIIISSEMPELLGITDRILVMSNGLVSGIVDTKTTTQNEILRLASLHL
Protein: Cyclin-dependent kinase 7 (EC 2.7.11.23) (Cell division protein kinase 7) (C9K505)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MAVDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDFVTFKSFPGIPLQHIFIAAGDDLLDLIQGLFLFNPCTRITATQALKTKYFSNRPGPTPGCQLPRPNCPVEALKEQSNPAVATKRKRTEALEQGGLPKKLIF
Protein: GTPase-activating protein gyp1 (GAP for ypt1) (O59737)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Stimulates specifically the GTPase activity of ypt1. Functions on the Golgi as a negative regulator of ypt1 (By similarity).
Subcellular location: Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q08484}. Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- GTP-binding protein ypt1
- GTPase-activating protein gyp3
- Small ribosomal subunit protein bS6m
- GTPase-activating protein gyp2
- Pre-mRNA-processing protein 45
Sequence:
MESQSKKSSALKTLSSLWNGSSSATSDPVTVLDRSRTHHHRGRSTSSKAQPFRLDDSVYSDQPPKDHISLARSITRPESASESKIYAPSARSSLSLEAVVGKKVSAKFAKYLSQTDDDWGVSNIKASKSLPRMARSTTPNSSSRSLFPQNGVDTTTSRQKLHSSGRFPLPAKLAHRSVEVEVAESNALVSRIKKFSRILDAPIVDLNALRTLAWNGIPSEHRPIVWKYLLGYLPCNASRREVTLKRKRDEYNAAKDSCFNTNTEPPPLDQTIWRQIVLDVPRTNPSILLYQNPLTQRMLERILYVWASRHPASGYVQGISDLVTPFIQVFLSEYIGDKDPMTYDIALLDETNRNDIEADAYWCLSKLLDGIQDNYIHAQPGIRRQVNNLRELTLRIDEPLVKHLQMEGVDFLQFSFRWMNCLLMRELSISNIIRMWDTYMAEGVQGFSEFHLYVCAAFLVKWSSELQKMEFQDILIFLQSIPTKDWSTKDIEILLSEAFLWKSLYSGAGAHLKR
Protein: Kallikrein related-peptidase 13 (A0A0U1RNY1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MWPLVATIACLTLALSEGISRDYPKILNGTNGTSGFLPGGYTCLPHSQPWQAALLIRGRLLCGGVLVHPKWVLTAAHCRKDGYTVHLGKHALGRV
Protein: Regulator of chromosome condensation 1 (C9JRH2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM
Protein: CAP, isoform U (A0A0B4K7W2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
Interaction partners:
Sequence:
MGQAFERSSSNSELQRPFVRRQLSDASRPAYRPNEVIYKVKHEYMSEPETGSDRPRKMAQLGRRQYDGIGPVTNDGMPIILRSEVKEPHQHEWYKRLYQTIHKQKNGDDFVIRYKCPRARPSYKSNGYVSEPEPNYDSDYSTVRYRTQNPHRVQSVSSAVNVRNLNQDEKLYGTMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKEWWDEVMDIFNGNLEQSKLSPLYTEGNLSRALAKESGYTSDSNLVFRKKEVPVSSPLSPVEQKQAYKSLQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVKGLSSYDFPYSTDTVDGSDVNIHFKTPIRHEQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSKRPSEGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKIANRKGIFPCSYVEVLTDIGAEDIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKTDALHVDTSSEPLAYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVERA