wanglab/gogpt-training-data huggingface dataset:
Protein: Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E) (Q66JT1)
Organism: Mus musculus (Mouse)
Function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (By similarity). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q6NSJ5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6NSJ5}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6NSJ5}. Lysosome membrane {ECO:0000250|UniProtKB:Q6NSJ5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6NSJ5}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6NSJ5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6NSJ5}. Note=In the absence of LRRC8A, resides primarily in the endoplasmic reticulum. Requires LRRC8A for localization at the cell membrane or lysosome membrane. {ECO:0000250|UniProtKB:Q6NSJ5}.
Interaction partners:
- Volume-regulated anion channel subunit LRRC8A
Sequence:
MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENISGAPCQQLLPQGISEQMGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENHKGPASGRAMVTTVTTTGAGSGKVGEGEKEKVLIEPEKVVSEPPVVTLLDKKEGEQAKALFEKVKKFRVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLIYVEKISFLVACRVETSEITGYASFCCNHTKAHLFSKLAFCYISFVCVYGITCLYTLYWLFHRPLKEYSFRSVREETGMNDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNMRGRLELSLCMLPGLPDTVFELSEVEALRLEAICDISFPPGLSQLVNLQELSLLHSPARLPFSSQIFLRDRLKVICVKFEELREVPLWVFGLRGLEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETLPTQLGQCFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQLSPDVAALQALSRLELKGNRLETLPEELGDCKGLKKSGLLVEDTLYEGLPAEVREKMEEE
Protein: Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) (Q02080)
Organism: Homo sapiens (Human)
Function: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Subcellular location: Nucleus.
Interaction partners:
- Calcineurin-binding protein cabin-1
- Myocyte-specific enhancer factor 2A
- Histone deacetylase 9
- Myocyte-specific enhancer factor 2D
- Homeobox protein Nkx-2.5
- Nuclear factor of activated T-cells, cytoplasmic 1
- Nuclear factor of activated T-cells, cytoplasmic 3
- Nuclear factor of activated T-cells, cytoplasmic 4
- Nuclear factor of activated T-cells, cytoplasmic 2
- Myogenin
Sequence:
MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVLLKYTEYSEPHESRTNTDILETLKRRGIGLDGPELEPDEGPEEPGEKFRRLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEALPAQSRPSPFRPAAPKAGPPGLVHPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTATPGPPLGSFPFLPGGPPVGAEAWARRVPQPAAPPRRPPQSASSLSASLRPPGAPATFLRPSPIPCSSPGPWQSLCGLGPPCAGCPWPTAGPGRRSPGGTSPERSPGTARARGDPTSLQASSEKTQQ
Protein: Phosphoglycan beta 1,2 arabinosyltransferase (E9AC97)
Organism: Leishmania major
Interaction partners:
- Phosphoglycan beta 1,3 galactosyltransferase
- Phosphoglycan beta 1,3 galactosyltransferase
- Putative phosphoglycan beta 1,3 galactosyltransferase
- Phosphoglycan beta 1,3 galactosyltransferase
- Phosphoglycan beta 1,3 galactosyltransferase
- Phosphoglycan beta 1,3 galactosyltransferase 4
- Phosphoglycan beta 1,3 galactosyltransferase 7
- Phosphoglycan beta 1,3 galactosyltransferase 1
Sequence:
MLHSRARTKPKLQQTESSAGAEARRGRDRGACVHGRRCLRGPLPFSCCPVLPTPTSFSRADTLLFSRLPLAVRHAGSFQWPDLRHSHDFQRSVLRCCCIFLVQRREHTTSMRGDITASFGLTARTFETHSCAEGRNQTGTQATRLSHAHRRPFFPRRHHCCAILVSCITIMYLLSTLHFLVMEPDVSRENAAVSGNETSTNISSPGIRLLTNELELPPIRVMAADHTCAMCTNGVVYTQTGEEGGPAAAASRPENVTAMVCRKVSKEEVDVLTSAEECVARLHRLGMLHAVAAREEDVNASCVRVMVPAIVGRMSGGSDSCPAFLAEIRPGIDKHAKLQVWFPRMPSWPLPGSRALPYVGTAAVRDTDIDRDVAPPVSVEITSDGSTIVLQFGRDATSTVPEAFELRCPTHFFSVLVGRWGRQHNQLQELLHSLAFARASNRTYVLPSFTPDTNLPYVRYSASNLYGFNAIRREGQYCLVTNAEVKPIFAQLQAMGVVMDMRRVDYMGVVKPHLSPQQMAQEIVRRWWVLPPVRDGVRKYNLESWFADSRSFSPPLRSVADYRADSVLFRESVEPLMGDDLFRTPTEAEQYSSWDRIKMFASRMLEVLGGDHVGDDAAGGAAQVRMAVISGKVAYFFHPQLEEVTRLFGLLRPSAHVSAEVDRMYSKSAAALGWPTTGSTKDADGQLVMRDTLRLANFKGVIGIHARLRERTCRAEAMRLWDTNLALTVDRYTVDSTDPNWAGVKSMVSSIESDCSWTAESAVELYLQYAHWLRSTMPGTFGHDYVPTTYVAYDDQSGPMADDMERIIQLLPEEVVVKDIGNLTAQYPRRFVASYDGRIKTSLKAVYNAARAKAVEQLEVHASSPNYYALLQKALLNMLYEPGLREMQAMSLDYIVLTNTEVFRGNIISSVATNVMLRRWGRGLPAHGLLAGYLESFYTGLY
Protein: Exported protein family 1 (Q8IC50)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MIIIVPFIFFNLIFTSDMMYEYIENTKVPIFVKLFFGKSIFIEDIFYYVGMIMKEMMEGQNIREEEVAELLKDRLDLYIDNEDEWEKLMENEISMLLKSSFSNFILESIGWTYENVSNIFLEEKANSGINKKDIYLKEANERMIRNSIVLRQCKSRFISIITNYYPFKEQNNPFIKQAQYVSSSNYVLDDIINNIDYSIDNIHRAIDNLYYEHILNLLEEEKNEILEEILRNILKIILCDVETTVRRSAQKVLQNAEGDTNLMLKRAKGLQSLGRMILQKVN
Protein: Paired amphipathic helix protein Sin3-like 3 (Histone deacetylase complex subunit Sin3) (AtSin3) (Transcriptional corepressor Sin3) (O48686)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a transcriptional repressor. Interacts with ERF7 to repress genes in abscisic acid and drought stress responses. The heterodimer represses transcription by tethering SNL3 to DNA.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810}.
Interaction partners:
- Histone deacetylase 19
- Histone deacetylase 6
- Zinc finger CCCH domain protein
- Ethylene-responsive transcription factor 7
- Paired amphipathic helix protein Sin3-like 1
- Paired amphipathic helix protein Sin3-like 2
- Histone deacetylase 7
- Protein ALWAYS EARLY 2
- Histone deacetylase complex subunit SAP18
- Putative histone deacetylase 10
Sequence:
MVGGGSAQKLTTNDALAYLKAVKDKFQDQRGKYDEFLEVMKNFKSQRVDTAGVITRVKELFKGHQELILGFNTFLPKGFEITLQPEDGQPPLKKRVEFEEAISFVNKIKTRFQGDDRVYKSFLDILNMYRRDSKSITEVYQEVAILFRDHSDLLVEFTHFLPDTSATASIPSVKTSVRERGVSLADKKDRIITPHPDHDYGTEHIDQDRERPIKKENKEHMRGTNKENEHRDARDFEPHSKKEQFLNKKQKLHIRGDDPAEISNQSKLSGAVPSSSTYDEKGAMKSYSQDLAIVDRVKEKLNASEYQEFLRCLNLFSKEIISRPELQSLVGNLIGVYPDLMDSFIEFLVQCEKNEGLLSGILTKSKSTYLLQGEGKYPQPSLDNDRDQEHKRDDGLRDRDHEKERLEKAAANLKWAKPISELDLSNCEQCTPSYRLLPKNYPISIASQKTEIGKLVLNDHWVSVTSGSEDYSFSHMRKNQYEESLFKCEDDRFELDMLLESVNSTTKHVEELLTKINSNELKTNSPIRVEDHLTALNLRCIERLYGDHGLDVMDVLKKNVSLALPVILTRLKQKQEEWARCRSDFDKVWAEIYAKNYYKSLDHRSFYFKQQDSKKLSMKALLAEIKEITEKKREDDSLLAFAAGNRLSISPDLEFDYPDHDLHEDLYQLIKYSCAEMCSTEQLDKVMKIWTTFVEQIFGVPSRPQGAEDQEDVVKSMNQNVKSGSSSAGESEGSPHNYASVADSRRSKSSRKANEHSQLGQTSNSERDGAAGRTSDALCETAQHEKMLKNVVTSDEKPESKQAVSIERAHDSTALAVDGLLDQSNGGSSIVHMTGHCNNNLKPVTCGTELELKMNDGNGPKLEVGNKKLLTNGIAVEITSDQEMAGTSKVEREEGELSPNGDFEEDNFAVYAKTDFETFSKANDSTGNNISGDRSREGEPSCLETRAENDAEGDENAARSSEDSRNEYENGDVSGTESGGGEDPEDDLDNNNKGESEGEAECMADAHDAEENGSALPVSARFLLHVKPLVKYVPSAIALHDKDKDSLKNSQVFYGNDSFYVLFRLHRILYERILSAKVNSSSPEGKWRTSNTKNPTDSYARFMTALYNLLDGTSDNAKFEDDCRAIIGTQSYILFTLDKLIHKFIKHLQVVVADEMDNKLLQLYFYEKSRRPETIFDAVYYDNTRVLLPDENIYRIECRLSTPAKLSIQLMCNGLDKPDVTSVSIDPTFAAYLHNDFLSIQPNAREDRRIYLNRNKRKVCREDEQLYSTDEVKIKNGLECKIACGSSKVSYVLETEDLLVRVKKRRKTLCHNQDSWVRQMRLQYYKNNFL
Protein: Lectin-related NK cell receptor LY49L4 (Natural killer cell receptor Ly-49L4) (Q9JIP9)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSEQEVTFSAVRFHKSSGLQNRVRLEETGKPQKAGLRVPWQLIVIALGILISLRLVIVSVLVTNIFQNSQQNHELQETLNCHDKCSTTTQSDINLKDELLSSTSIECRPGNDLLESLHKEQNRWYSETKTFSDSSQHTGRGFEKYWFCYGIKCYYFVMDRKTWSGCKQTCQISSLSLLKIDNEDELKFLKLLVPSDSCWIGLSYDNKKKDWAWINNGPSKLALNTMKYNIRDGGCMLLSKTRLDNDNCDKSFICICGKRLDKFPH
Protein: Maltase-glucoamylase (EC 3.2.1.20, EC 3.2.1.3) (Q6XK23)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MRNKAIGAETTGTPDTTVTRTTLNSPNCPVLSELERINCIPDQSSNKGTCDERGCCWDPQGSISVPCYYSRNHGYKMESDVVNTNAGFTATLKNLPSAPVFGNSIENILLTAEYQTSNRFHFKLTDQTKKRYEVPHEHVQPFSGNAPSSLNYKVEVSKEPFSIKVTRKSNNRVLFDSSIGPLLFSDQFLQFSTHLPSANVYGLGEHVHQQYRHNMNWKTWPMFSRDTTPNEDGTNLYGVQTFFLCLEDNSGLSFGVFLMNSNAMEVTLQPTPAITYRTTGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWTLG
Protein: Sugar phosphate transporter domain-containing protein (Q585Z4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Lipophosphoglycan biosynthetic protein 2, putative
Sequence:
MTRHENVEHGVVLKWMRGGNLKVLFSLLLNIVSSVGVIIVNKRLVYNEAGFHFVTLLTVMHFIASFFGCLMLSLFGFFEIKRLHIAQVLTISAAFCGYVVFNNFSLLANTVSVYQTSKILCTPLIVLIEYAAYNKQETKETLLAIFITCLGSGITVCADTRLTVEGTIWALLAILANSLYTIWGNTKQKDLGVNAAQLLIYQAPVSSLMLLFAVPIDGLTELRSYEVTPTSVWTIALSCILAFGVNLSFFLLVGQTSPLTTNIVGYLKTVLVFIGGFVFISSEADTKTLLGVTVTLVGLGCYTATKVRALSSPSSAKESRLT
Protein: GTPase activating protein 1 (OsGAP1) (G-protein binding protein 1) (OsGPBP1) (Q6YWF1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (By similarity). Stimulates the GTPase/ATPase activities of YCHF1, and regulates its subcellular localization. Binds phospholipids in a Ca(2+)-independent manner. Promotes tolerance towards salinity stress by limiting the accumulation of reactive oxygen species (ROS). Promotes resistance to bacterial pathogens, such as Xanthomonas oryzae pv. oryzae and Pseudomonas syringae pv. tomato strain DC3000. Binding to YCHF1 is required for its role in stimulating defense responses and the ability to alleviate salt stress.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20876569, ECO:0000269|PubMed:23550829}. Nucleus {ECO:0000250|UniProtKB:Q9LVH4}. Cytoplasm, cytosol {ECO:0000269|PubMed:20876569, ECO:0000269|PubMed:23550829}. Note=Localized mainly in the cytosol under NaCl treatment, but translocates to the plasma membrane upon wounding. {ECO:0000269|PubMed:20876569, ECO:0000269|PubMed:23550829}.
Interaction partners:
Sequence:
MLGHLVGLVKVRVVRGVNLAVRDLRSSDPYVIVRMGKQKLKTRVIKKTTNPEWNDELTLSIEDPAVPVRLEVYDKDTFIDDAMGNAELDIRPLVEVVKMKIEGVADNTVVKKVVPNRQNCLAEESTIYISEGKVKQDVVLRLRDVECGEIELQLQWVDIPGSKGV
Protein: F-box domain-containing protein (Q4GYB3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- PAB1-binding protein 1
- Post-transcriptional regulator MKT1
Sequence:
MSLEEGSSEMRLSGAAFLKGAVDDFHAGKSSALSSGSSPALTVSVFSTPAFGCSTFGNSSPVCGGHEANYEAVALRDAPLSSRGIVAWDRMKCESSLFVKLQASSGLSGTDSEDIANPLVDLSDACGTDALSELREEHQHISSVASEKPLTLHDVPESVLYGAIPYLSLPDVIALSRTCKKFHKLVQGYFAVNEHGVMSIPAFDTRSFMQYRPERKPPVTKVTAAGPAPKIPGVKPIRLFFGQQRRDVYPSALRRLLRFIAPDLVITHMEAHVNEATGRGKGCAWVIVPSVLEAKRLLRLSGRIFLDINSNGEEVYLFAPPNCREWLSEYADYVVSSTTRASHLPYLPMVVGVPKKECIYVRELLAPYIYDPNRGDCPPYADAVSEFKGLLEDHALLPVSSAVSGIIPPFASVPPMVQTCMFSSSFDRREYFEAPNVYTSTVWTGFSRYRHDPYVFDPLREPTNMLPLHEVDYAEM
Protein: Glutamate--tRNA ligase, cytoplasmic (EC 6.1.1.17) (GluRSAt) (Glutamyl-tRNA synthetase) (GluRS) (O82462)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:16251277, ECO:0000305|PubMed:16297076}.
Interaction partners:
- Methionine--tRNA ligase, cytoplasmic
- Leucine--tRNA ligase, cytoplasmic
- Isoleucine--tRNA ligase, cytoplasmic
- Glutamyl-tRNA reductase 1, chloroplastic
- Proline--tRNA ligase, chloroplastic/mitochondrial
- Proline--tRNA ligase, cytoplasmic
- Glutamyl-tRNA reductase 2, chloroplastic
- Probable glutamyl-tRNA reductase 3, chloroplastic
- Arginine--tRNA ligase, cytoplasmic
- Arginine--tRNA ligase, chloroplastic/mitochondrial
Sequence:
MDGMKLSFPPESPPLSVIVALSLSASPVTIDSSAAATTVPSFVFSDGRKLNGATVLLRYVGRSAKKLPDFYGNNAFDSSQIDEWVDYASVFSSGSEFENACGRVDKYLESSTFLVGHSLSIADVAIWSALAGTGQRWESLRKSKKYQSLVRWFNSILDEYSEVLNKVLATYVKKGSGKPVAAPKSKDSQQAVKGDGQDKGKPEVDLPEAEIGKVKLRFAPEPSGYLHIGHAKAALLNKYFAERYQGEVIVRFDDTNPAKESNEFVDNLVKDIGTLGIKYEKVTYTSDYFPELMDMAEKLMREGKAYVDDTPREQMQKERMDGIDSKCRNHSVEENLKLWKEMIAGSERGLQCCVRGKFNMQDPNKAMRDPVYYRCNPMSHHRIGDKYKIYPTYDFACPFVDSLEGITHALRSSEYHDRNAQYFKVLEDMGLRQVQLYEFSRLNLVFTLLSKRKLLWFVQTGLVDGWDDPRFPTVQGIVRRGLKIEALIQFILEQGASKNLNLMEWDKLWSINKRIIDPVCPRHTAVVAERRVLFTLTDGPDEPFVRMIPKHKKFEGAGEKATTFTKSIWLEEADASAISVGEEVTLMDWGNAIVKEITKDEEGRVTALSGVLNLQGSVKTTKLKLTWLPDTNELVNLTLTEFDYLITKKKLEDDDEVADFVNPNTKKETLALGDSNMRNLKCGDVIQLERKGYFRCDVPFVKSSKPIVLFSIPDGRAAK
Protein: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (Q9JK42)
Organism: Mus musculus (Mouse)
Function: Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:21190881}.
Interaction partners:
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- [Pyruvate dehydrogenase
- Pyruvate dehydrogenase protein X component, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
- [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
- RAC-alpha serine/threonine-protein kinase
- Rapamycin-insensitive companion of mTOR
Sequence:
MRWVRALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLGTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNATNANQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLTLPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
Protein: glycogenin glucosyltransferase (EC 2.4.1.186) (A0A0B4LG72)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSKFAWVTLTTNDTYSLGALVLAHSLKRAKTAHQLAVLVTPNVSQAMRDRLKEVYNVVQEVNVLDSQDAANLALLSRPELGVTFTKLHCWRLVQFEKCVFLDADTLVLQNCDELFEREELSAAPDVSWPDCFNSGVFVFKPSVDTFAQITEFAVKNGSFDGGDQGLLNQFFADWSTADIKKHLPFVYNVTAYASYCYLPAFKQFRDKIKILHFAGKLKPWLIQFNSETKVASVSSEYAHAQDLIQLWWNIFCENVIQSLSTEMAGLAGALSQLRIGQQRTPEQEAYENQMRRQCWESGQIDYTGADSFENIWKKISQTLERKTDKESEETVVYF
Protein: Corticoliberin (Corticotropin-releasing factor) (Corticotropin-releasing hormone) (G8F161)
Organism: Macaca mulatta (Rhesus macaque)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQYPQPLDFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGANFFRVLLQQLLLPRRSLDSPAALAERGAENALGGHQEATEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
Protein: ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (P41971)
Organism: Mus musculus (Mouse)
Function: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MESAITLWQFLLHLLLDQKHEHLICWTSNDGEFKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDKNIIKKVIGQKFVYKFVSFPDILKMDPHAVEISRESLLLQDGDCKVSPEGREVHRHGLSSLKSASRNEYLHSGLYSSFTINSLQNAPEAFKAIKTEKLEEPCDDSPPVEEVRTVIRFVTNKTDKHITRPVVSLPSTSETAAAAASAFLASSVSAKISSLMLPNAASISSASPSSSRSPSLSPDSPLPSEHRSLFLEAACHDSDSLEPLNLSSGSKTKSPSLPPKGKKPKGLEISAPQLLLSGTDIGSIALNSPALPSGSLTPAFFTAQTPSGLFLASSPLLPSIHFWSSLSPVAPLSPARLQGPNTLFQFPTLLNGHMPVPLPSLDRAPSPVLLSPSSQKS
Protein: Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (ATP diphosphohydrolase) (Ecto-ATP diphosphohydrolase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) (Q6DC46)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane, caveola {ECO:0000256|ARBA:ARBA00004345}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEVKVKNPWHRPVVIFLMAVVAVGIVIMVSISVVQHKPLPQKYKYGIVLDAGSSHTSVFIYKWPAEKENNTGMVQQHHTCNVKGKGISSYFDKPHGAGASLEECMKEAKEKIPAHRHSETPVYLGATAGMRLLKMEDEMASEKVLTSVAHSLKTYPFSYQGARILSGQEEGAFGWITVNYLSENLRKPAGTLGALDLGGASTQITFVPQQIIESSDNSIDFRLYGNDYHLYTHSFLCYGKDQALKLAMAEKLRSTPDKTDAILLRDPCFHPGYNTTKTLESVNTPCMKPLKMPKEQFSHVGLGNWSQCQESIRKVFNTSHCPYSGCSFNGVFQPTVEGKFGAFSAFFFVMDFLNLKNDSLDKTKQRLAMYCSTPWQKIVQDHPKVKEKYLSEYCFSATYILTLLEHGYNFTSDNWNDIKFIKKIGDSDAGWTLGYMLNLTNMIPAEDPDKPLMPHGGYVTFMILFSLLILVLIIMAYIYFRRFTKTAQKDII
Protein: G protein subunit beta 5 (A0A3S5ZPL0)
Organism: Bos taurus (Bovine)
Interaction partners:
- Guanine nucleotide-binding protein G
- Regulator of G-protein signaling 7
- Guanine nucleotide-binding protein G
- Phosducin-like protein
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Regulator of G-protein signaling 9
Sequence:
MGTTFLRAGRLCANISVAGGTERGRGGAEVALFLRPAEREEDRPPQPGSQRRRTRRRAGRARGGDWSCAGGGWAPASRPGHRRLLTRIPASLPPRPRAKMAADGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRLVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
Protein: M-phase inducer phosphatase (EC 3.1.3.48) (D4ADT2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase PLK1
- 14-3-3 protein epsilon
- CHK2 checkpoint homolog
- 14-3-3 protein zeta/delta
- Cyclin-dependent kinase 2
- G2/mitotic-specific cyclin-B1
- 14-3-3 protein beta/alpha
- Mitogen-activated protein kinase 14
- 14-3-3 protein theta
Sequence:
MSTVPFPAASEEGSYVSAPSFRFKQRKMLHLLLERHASFTVGSDFPESPGDKLHDSANLSLLSGGTPKCCLDLSSLSNGEVSASHLSTSADIEENGSLDSSGPQDIHLTGKDFHQDLMKGIPAQLLCSTPNALDHGHRRKDAKCSTSANKENINTSFKTLEWEAPRTPRLQKKPGDPLASPLCELENGILLESEMKNLGSPITTVPKLSKNLKLEDQEGISEDPMECSLEDQDAKGLSLKKTVPLCGMDAIELEEEDSDSEHLTGDFSKACVLPTVPGKHQDLKYISPDTVAALLSGKFQSVIERFYIIDCRYPYEYLGGHILGALNLYSQKELYEFFLKKPVVPEDTQKRVIIVFLCEFSSERGPRMCRSLREKDRALNQYPALYYPELYILRGGYRDFFPEYMELCEPQGYCPMLHQDHQAELLSWRSQSKAQEGERQLREQIALLVKNVSPQ
Protein: Synaptophysin-like 1 (A0A0G2KA82)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- General transcription factor IIF subunit 1
Sequence:
PVVREPPRSKAAGRRWRPASSLRCRRLLPAAPSRGGVGARSLFSQASLRSAKEDRTSCCGPTDYGPPGGPRLPRARLDLGCVLRWRRFASIFAFATCGGFKGKTEIQVNCLSAPGENKTITATFGYPFRLNQASFHSAPNVNVCKVNWEKHVLIGDYSSSAQFYVTFAVLVFLYCIAALLLYVGYTNLYRDSRKLPMIDFIVTLVATFLWLVSSSAWAKALTDIKVATGHRIVEELDPCKSEVSCYFVSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKETSLHSPSNTSASHGQGGVPPTSGM
Protein: Protein PTHB1 (Bardet-Biedl syndrome 9 protein homolog) (Parathyroid hormone-responsive B1 gene protein homolog) (Q811G0)
Organism: Mus musculus (Mouse)
Function: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization (By similarity).
Subcellular location: Cell projection, cilium membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250}.
Interaction partners:
- BBSome complex member BBS1
- BBSome complex member BBS5
- BBSome complex member BBS2
- BBSome complex member BBS7
- BBSome complex member BBS4
- Tetratricopeptide repeat protein 8
- BBSome interacting protein 1
- Leucine zipper transcription factor-like protein 1
- BBSome complex assembly protein BBS10
- Chaperonin-containing T-complex member BBS12
Sequence:
MSLFKARDWWSTVLGEKEEFDQGCLCLADVDNSGNGHDKIIVGSFMGYLRIFSPHSVKAGGGPQAEDLLLEVHLRDPVLQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQYQIKLMYEHHLQRTACNMTYGPFGGVKGRDLICIQSLDGMLMVFEQESYAFGRFLPGFLLPGPLAYSPRTDSFITVSSCRQVESYKYQVLAFATDADKKQEMEQQKLGSGKRLVVDWTLNIGEQALDICIFPLNQSASSVFVLGERNFFCLKDNGQIRFMKKLGYNPSCFLPYCSVSEGTINTLIGNHNHMLHIYQDVTLKWATQLPHVPVAVRVGCFHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDVELKELQKIIKDVKLQGVWPLTEQEDDLKVSASVSSTLDSVSQATNVEPGADSVPSITVKITLQNRVVLQKVKLSIYVQPPLQLTCDQFTFDFTVPDMTSSVAFSVYLKRNYTPSELEGNAVVSYSRPTDRNPDGIPRVVQCKFRLPLKLICLPGQPSKTASHKLTIDTNKSPVSLLGLFPDFANPSDDDQVNVMGFRLLGGARVTLLASRTSQRYRIQSEQFEDLWLITNELILRLQEHFEKQGTKDFSCSFSGCVPLQEYFELIDHHFELRINGKKLEELLSERAVQFRAIQRRLLTRFRDKTPAPLQHLDTLLDGTYKQVIALADAIEENQDRLLQSFSGLKSATHLLILLIRLWQRLSADQTAILEAAFLPLQEDTQELGWEETVDAAIAYLLKTCLSKSSKEQALNLSSQLNIPKDTSRLKKHITLLCDRLAKGGRLCVSTDAAAPQAMVVPGGCTPIPESDLEERSLDDSTELFTNHKHLMTEPPMPEVSARQGVLE
Protein: CKLF-like MARVEL transmembrane domain-containing protein 2 (Chemokine-like factor superfamily member 2) (Q8TAZ6)
Organism: Homo sapiens (Human)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Chemokine-like factor
- CKLF-like MARVEL transmembrane domain-containing protein 3
- CKLF-like MARVEL transmembrane domain-containing protein 4
- CKLF-like MARVEL transmembrane domain-containing protein 7
- CKLF-like MARVEL transmembrane domain-containing protein 5
- CKLF-like MARVEL transmembrane domain-containing protein 6
- CKLF-like MARVEL transmembrane domain-containing protein 8
Sequence:
MAPKAAKGAKPEPAPAPPPPGAKPEEDKKDGKEPSDKPQKAVQDHKEPSDKPQKAVQPKHEVGTRRGCRRYRWELKDSNKEFWLLGHAEIKIRSLGCLIAAMILLSSLTVHPILRLIITMEISFFSFFILLYSFAIHRYIPFILWPISDLFNDLIACAFLVGAVVFAVRSRRSMNLHYLLAVILIGAAGVFAFIDVCLQRNHFRGKKAKKHMLVPPPGKEKGPQQGKGPEPAKPPEPGKPPGPAKGKK