Protein: Dynein heavy chain domain-containing protein 1 (Coiled-coil domain-containing protein 35) (Dynein heavy chain domain 1-like protein) (D3Z2X2)
Organism: Mus musculus (Mouse)
Function: Essential for the normal function of sperm flagella axonemes.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:34932939}. Note=Predominantly concentrated in the mid-piece of the sperm flagella. {ECO:0000269|PubMed:34932939}.
Interaction partners:
- Dynein axonemal intermediate chain 1
- Dynein axonemal light chain 1
- Dynein axonemal intermediate chain 2
- Dynein axonemal intermediate chain 3
Sequence:
MKPHSQTSPPSLPMPSTSCRPGQTQKPKAWNWHLDPELWARSVRQQLNTCLHFILEEKKNPWFYTLQSGLVGCSCSGQEHSWDCQMKQEDLKAVVESEQRTLLKLLLSELQSLFSAVMQDGSCEAWRYLHAVLGLLPPYREMLAGQLELLPFLEQLYCWAPKVQARLELDLLDAIDKAFPPDSSLLHSSSHVDCGLWMKRFHRGPPCSACPFVKAQWDRQQKKELATWLRPLTLPELQHCLGIVGAEVALEETPWLDSLSLLPLALATDIPVQYESSDTEQAEGEPAGRKLQVASEAPEEKALKKKSSRTPVLRSQVKSLLERDWTQKKIHFLYLNVVSDRHFNPYKLVAVPPDKVNPEHYIFSPFGILHIHPVEGSEAMTLGTWHRDCALWRELQRIPFFKNCLLRKALTCWKKNVRLCGLHRIQTFLKTHLLSAIPHFGAGMLHINRLLQEFRSVSWLPKEPDRSYELVDLQKAIAKENHKALRVLCHFLNLCTSILQLIHEDTYQMQQGLQERVQNWNRIRKGQGSIYLQRTLCRHLEKKLKQAETWLLKLGKFARLIDYMICQNLVSILEDEISSFIANTLQAPRQNPFLLSQLVFDDNGQLSPMPRVESIIQGLIKSLQSIKTSALKVLQSTDLRTSRDLLYSEDNKDQDSNAEFLMPKFHGKASDAVRLFCGPNVGYVWPWKSHAITDVLEVRGHKLRGQFLHPNYDHVQEDLDKNAGIQQALAVQQSLLEDMRQEVQEFCNKHKWVEGIYEFLKAWSSQKLEDLRGSPINNYVNLVIQLKKWQERVSNMSVELLTKGKLLFLSGHDVQEELGSKLNNMRKNILEQAQNECWSRNQQLMTELTEFLRVFQTISSDIHAIAQCSQKLSEANEQYCQLEERVEYVRSLHDLIRNHCALFIAENETLDIALLDLWEAFQFERSQVSEFLLSKQHAIVPRLQQLMAAALAELEGLLAKALSGPFMDPSQEQRSTEQQLGALEHQFLNILNNFNALCNAYCTFTGYKKPMSPPASGNRPIVLQQRIWRLYRIISENLGEWKCVAFSKFNLSMAREKTDAWLTEAVRLSTALGLQSPVLQRCMRMLEEFRAYLPLLIKLGNLQLQDLNTQSLLRALGLGSLRSLDLLTLGQMLNYPLLEFAERINQVWQYDKERIHAQEILQQMQQYWEGRQLRLLNFILHVPYKPPTSERSKRPALRSPQWELVGKDSGTFLLSDYSSLQDAIQNSLQALFKILAIQKSGQLHKIALEWVAIMYGLGALLEVWVAFQQKWIFLNKVLHEMKIEFPAPELNARFKAMDDQYRTLMRISVADPMVLSLILPNTKRSPYFQGQHLQQMLKAGSGELEAIIMALEDVLYGVCANFPRLFFLSDSELVALLAAPLDTREAQLWAQRCFPHIKAVNFRSKSTKKKINQDSSSSTESAETIAVLAAGGEEVKLQEPLPLHTDLPKWLASLEKCLRFIIVNLLQSCVATRLAQGPSLIKALKAMPQQRQMPMQVYVQHWLDAVQVFPWQCILVAEEVVWRAEMEEALLESRTMHMRSVHVHNLEVLVQFIRSQRSSQDGKSLPSVRQTSLFSTLLVKAVTHRDIAQLLEKNQVSDLTDFHWVRQLKYHLGSSHLNLKSPVQCLTTIASTEPSVSPAACWIDVLGRSFMYNYEYMGPKLGPLPSLMHERQVFILLMALDEVAYGAILGRDGLGKAETVNSLAWTLGRQLVIMPCLPQIEFQCLRNYLNGALQSGAWLLLENVNQLPSSLLSALGQRLDELHYLYAPLYQKASKNISTINPTKPLLLGGGFFEKHQVSMRLGFGCFLTLHSLGPDIPANLHLLLRPVALALPDLQRVAELNLLGAGVQDASQMASRLSKLFSLERELVSGNLPCRLPLLKQVLEHTIQTLNTSQEKKSQQPYDPAASEEAALLRALLHSPLFSILDGLRLQKLQELLCGIFPNASHVLAEPVSHRLIKSVVVEELQQLGLFPASNTVTSLEQLSQALSRASGILLLGPAGSGKSTCWRSLFKIQNRLAAMEHTSTKGFQSVEIVHLYPSVLNSKEYLGWSEGPSWHYGIFPKLLHAAPYCKSVGSEEPSEKFTGIQQWIICDGAPNHAWTDSVTCLLRDPPQLSLPNGQQIARPLGTFFLIEVAEAAGMSPTVLGRCALVWCSGEQTWHSMLSVLMASLPHEYHLQQETITEFNYLAEVLVPSVLRFLTRIGASSQLQVHGHQAVCPGVAEVTSLVRILRALLDPLLHLFEEEKSYTKEDFSGSDLVTQNFKSSKTRVQSDRVNVNKKQRRHLLAISSFLFAIIWSFGAHLPSRHWPLFDDFMKKSISSLPNYPEPPPSALVFDLHVNFEDGTLVPFTGQYLSTHVKGNLGSFQPSSQTEQLLYVVDLLLSNGQPVLLAGEIATGKSAFVEVLVKPNYPVIHSPIHPALNSTHLRHLLSRGVHGQTQASSIPGHHQDSKGSILFLMEDLHLATFDPEKNCQPVLETLRQAMEGTIYAHNTLELQTLQTTVNFLATATVPGYSERPLCPRLYRLFTVLALNSMTQDTLLSRHVPSIQAWLERFPSVEREHTLARALVRASVEAWEAVCKCFMPSPLRPHYRFSPHSVSHILGSLQLLPTRMGSRGFAETFHHQEYLRRVSGLRGTRLTIMMSMRVMVRLWLHEAQRTFCDRLDSDRERSHCAKLLLEVAQNVFCGGPGSESLAKDCEEEEVEEEKVPEVESEEEIAQWETLSNSDSGSEEEEDPYGLQATTGSFLSENSLAPFPRKSVNKENTENVSQMAEQEEDIRDSSSKLQSKTPKHEWQMAPQMDLSLPLLLPVLLFYPQESPSDLVFSLELTLGSNFESPNLYLERQWENLEKQLVATAVRLKMNSGFSQCPVMVQHVAHLVRVLARPQQHALLLSEFRGTGRYTAIILASSICQAHLHYLSVESEEAIFQCLRDASWHAGLLNQPVALLVPEGVNVAIFCRLLALATSGSFPDQYTEADLDNIEEHFPKENIANKHAIKRDTILNRFYQQVCNNLHMFFMVGDNQAQNQLAPTLFLNLLQLTIASVERYEPWDQASLVRIAQFCLENDHSLPLDDGSLKYPDFKHLIPNVANIMARIHVSSACYHKHMCPALPLVTPKTFQDFLDMFLQQQQQMVLQMRMRASRIQTALKTLRLMVERHSTQTSLLTDLEAQLKGSYKSVGICQGQLEQSKIMYRQKMIECQHQESLIENLVRQHDALKAQQEVFLEQMGKAFVGPLSQLRVADFEEIRSYRAPPESVVKVTDALCDLFHQETGWSSAKQLLCTEDFYQELVFFPKEKLTDSELVKLNEALRAPGMSDAALRSVSIPAANLAVWLWAVLRYGLAQRRGLPTGLLLRQVDATLAREQARLGQFQFQAHDLLEQTRSLTKKLEDAQVSHNHVMETLNQAQCGNFQKWPMESALLTPMHMWTTQLQKLQEQAKTVFGDALLCSAAIIYLGPFPPQRRQELLEKWLSLCQGSEEALDPDDVARALRQKSVGVPKNPLLPTRTPFSILTLLSYGSELHQWDRDLKPQAKSARLLGLLLRSHIHFSSSRWPLLIDPSNQAIMWLNPLPPKQNRSLEPSPKESKEKFHVTKQDSGDNTEDELEDENNEEEDEANEQRKEQKAEENKIQGENEQEVQETEKENEPESSGSHSSLPSETQSLPSCLTVLSGTDPELGPQLLEAAANGLPVLLTNVELSLGCQELQWLLSKKNLSPPSVQPGFCLFLSTTFPIHALSRVLGFEMLKGLNVLDLGLNMEILEEQMLHEILCRERPELETRWQDLKIRAADTYEAMKADEEQLLVTLLRQNQKRQKPSKFLRKMVRTQAKICQLNAQMEELEDQKQEVVALWAPYRPVAYHGMAMVEALSPLQNLLPSFCMTSENWLAVIRRAIDSMKSYDSYRGEDLPSHLLRLKIHLARQLLTNTVVALGLIQTPLVGAFGALAMLQVTTKTPKLERLALWPGLSASPSSGHNMQIPGVIRPAWLSSKAWEECGALELLPPFAGLCESLAGHSGVWQDYLSLSSTVLGPAPGPNSEPLSLFQKLILWRVLRPDCLAGALADLTTSLLGRPLDENLGAPTMIFEHIQPTQPILILLPPPGHPTATLHPVTVIRKLAANHEKPQHLHVIALGSEDWDPVSTVVNTLCQAMLQGHWLVLDNCHLMPFWPRELLQPLQGLLDRARVVSDSELLAEPESRSVVTVHRDFRLWLIVPTEASTSLPGMLTQSSMPVFWNQSLELGRILIDSLDSQQGLCTQPLTQTLPLFFLHGLLLHRQLYGLKLQAHRGRWSQVTLTRALQIQEQLWASLGNPSAALLELTASVLYGGSLGDLEDREALVSLTRTCLNPRNMNWDQPHTPQYLLATLMPSPELGELDARTDCKAQMHLLPTPPEPRTCGLNEAPQAWLMRRQSRVLLNALQKCSSTWVPTVCGGIAQRKERQLQQRLAQAKKRLVALQALLTNNRIRSGQCVTPWAVLGPNARRPLEGFLETEVLELKHLVGTLLCDLDCLLQQLKGGTPCTSSRCAKVAQALWAGHLPQPWRSHALAGSQLPWLWLRQLSRRGHLLIRYLDSGMSENANKPERIFHLSAFRHPGRLLLALRWEAVLENSVHNPNLPGHQDSISGSLPPKWQELSNHPLHIWVENGPNPKVPKMGLLLTGLQLQHAEWDQTDGALQDSFSSQPCPLPPVSISTQARRGKDAPVSAGLGMYSCPVYMTGPFGTTKLHSKNILMHLPLPTRLSPDTCIQRRVHVCSPTLT