wanglab/gogpt-training-data huggingface dataset:
Protein: Protein phosphatase PTC7 homolog (EC 3.1.3.16) (T-cell activation protein phosphatase 2C) (TA-PP2C) (T-cell activation protein phosphatase 2C-like) (Q8NI37)
Organism: Homo sapiens (Human)
Function: Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:30267671}.
Interaction partners:
- [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
- Protein phosphatase 1A
Sequence:
MFSVLSYGRLVARAVLGGLSQTDPRAGGGGGGDYGLVTAGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPIGILTTSYCELLQNKVPLLGSSTACIVVLDRTSHRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDVQLGDIILTATDGLFDNMPDYMILQELKKLKNSNYESIQQTARSIAEQAHELAYDPNYMSPFAQFACDNGLNVRGGKPDDITVLLSIVAEYTD
Protein: SH3 domain-binding protein 2 (3BP-2) (P78314)
Organism: Homo sapiens (Human)
Function: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
Interaction partners:
- Proto-oncogene vav
- Poly [ADP-ribose] polymerase tankyrase-2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Guanine nucleotide exchange factor VAV2
- Guanine nucleotide exchange factor VAV3
- Tyrosine-protein kinase SYK
- Tyrosine-protein kinase ABL1
- Poly [ADP-ribose] polymerase tankyrase-1
- E3 ubiquitin-protein ligase RNF146
Sequence:
MAAEEMHWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLLKWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHISKKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDSSSDTDSFYGAVERPVDISLSPYPTDNEDYEHDDEDDSYLEPDSPEPGRLEDALMHPPAYPPPPVPTPRKPAFSDMPRAHSFTSKGPGPLLPPPPPKHGLPDVGLAAEDSKRDPLCPRRAEPCPRVPATPRRMSDPPLSTMPTAPGLRKPPCFRESASPSPEPWTPGHGACSTSSAAIMATATSRNCDKLKSFHLSPRGPPTSEPPPVPANKPKFLKIAEEDPPREAAMPGLFVPPVAPRPPALKLPVPEAMARPAVLPRPEKPQLPHLQRSPPDGQSFRSFSFEKPRQPSQADTGGDDSDEDYEKVPLPNSVFVNTTESCEVERLFKATSPRGEPQDGLYCIRNSSTKSGKVLVVWDETSNKVRNYRIFEKDSKFYLEGEVLFVSVGSMVEHYHTHVLPSHQSLLLRHPYGYTGPR
Protein: UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (P76373)
Organism: Escherichia coli (strain K12)
Interaction partners:
- UTP--glucose-1-phosphate uridylyltransferase
- Bifunctional polymyxin resistance protein ArnA
- UTP--glucose-1-phosphate uridylyltransferase
- UDP-glucose 4-epimerase
- dTDP-4-dehydrorhamnose 3,5-epimerase
- UDP-galactopyranose mutase
- Lipopolysaccharide biosynthesis protein WzxC
- Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
- Putative O-antigen transporter
- Glucose-1-phosphate thymidylyltransferase 1
Sequence:
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAERFAALLQEGAIKQNIPMLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNSRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD
Protein: Alpha-1,2-galactosyltransferase gmh3 (EC 2.4.1.-) (Q10359)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the galactosylation of the N-linked core oligosaccharide Man(9)GlcNAc(2).
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein C4C3.09
- Meiotically up-regulated gene 136 protein
- Uncharacterized protein C5H10.12c
- GTP-binding protein ypt5
Sequence:
MAVLQWKLSRVIFVLLIIGISSFLIYFQFGNSFSASPALERLQDVFSKPSVQEYDYLVPLDEDMQGLSTTYHQATINEDDPQEPKSHEIVILLASDGRSSGNMAPETFNQCIENRINYAKHHNYGFEYVNVSQMNIPPVWAKMPAIIQTMNKHPHAKWIWWLDQDALILNTELSIQEHILSPDVLVEKLMKNEPMISPFSADLERLTPSSYTVDSARSLGLLISQDLNGLNAGSFFVRRSPMMALFLDLWGDKSFRENKVADHEQALLGYFVRYHPEIAAIIGILPQTLINSYPVGQPEMGWKEGHLVIHFAGCWVENRCQVLWDEYRERVH
Protein: Allatostatin A receptor 2, isoform B (MIP19959p) (D6W4V7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MENTTMLANISLNATRNEENITSFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMIMRLWRQGTGVRMSKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKGLQSNRLGMWTTTHQDVSSEKTTY
Protein: Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase) (Q14117)
Organism: Homo sapiens (Human)
Function: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
Interaction partners:
- Dihydropyrimidine dehydrogenase [NADP
- Beta-ureidopropionase
- Uridine 5'-monophosphate synthase
- Dihydroorotate dehydrogenase
- Dihydropyrimidinase-related protein 5
- Dihydropyrimidinase-related protein 3
- Dihydropyrimidinase-related protein 2
- Multifunctional protein CAD
Sequence:
MAAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVLPGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSWADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHHQAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRDRTCTPTPVERAPYKGEVATLKSRVTKEDATAGTRKQAHP
Protein: Large ribosomal subunit protein mL45 (39S ribosomal protein L45, mitochondrial) (A0A087WU62)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MAAPIPQGFSCLSRFLGWWSRQPVLVTQSAAIVPVRTKKRFTPPIYQPKFKTEKEFMQHARKAGLVIPPEKSDRSIHLACTAGIFDAYVPPEGDARISSLSKEGLIERTERMKKTMASQVSIRRIKDYDANFKIKDFPEKAKDIFIEAHLCLNNSDHDRLHTLVTEHCFPTLAIYDRFGRLMYGQEDVPKDVLEYVVFEKQLTNPYGSWRMHTKIVPPWAPPKQPILKTVMIPGPQLKPEEEYEEAQGEAQKPQLA
Protein: Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1) (O00337)
Organism: Homo sapiens (Human)
Function: Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs. Transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21998139}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q62674}. Apical cell membrane {ECO:0000269|PubMed:21998139}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q62674}.
Interaction partners:
- Equilibrative nucleoside transporter 2
- Equilibrative nucleoside transporter 1
- Solute carrier family 22 member 1
- Equilibrative nucleoside transporter 3
- Equilibrative nucleoside transporter 4
- Cytidine deaminase
Sequence:
MENDPSRRRESISLTPVAKGLENMGADFLESLEEGQLPRSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRARSFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLLLWFKRGLALAAFLGLVLWLSLDTSQRPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGILYMPRGAEVDCMSLLNTTLSSSSFEIYQCCREAFQSVNPEFSPEALDNCCRFYNHTICAQ
Protein: Hexose transporter HXT11 (Low-affinity glucose transporter LGT3) (P54862)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable glucose transporter.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Carbon catabolite-derepressing protein kinase
- Transcription factor PDR3
- ATP-dependent permease PDR10
- ATP-dependent permease PDR15
- Protein SNQ2
- Transcription factor PDR1
- Pleiotropic ABC efflux transporter of multiple drugs
- Oligomycin resistance ATP-dependent permease YOR1
- Inositolphosphotransferase 1
- DNA damage-inducible protein 1
Sequence:
MSGVNNTSANELSTTMSNSNSAVGAPSVKTEHGDSKNSLNLDANEPPIDLPQKPLSAYTTVAILCLMIAFGGFIFGWDTGTISGFVNLSDFIRRFGQKNDKGTYYLSKVRMGLIVSIFNIGCAIGGIVLSKVGDIYGRRIGLITVTAIYVVGILIQITSINKWYQYFIGRIISGLGVGGIAVLSPMLISEVAPKHIRGTLVQLYQLMGTMGIFLGYCTNYGTKNYHNATQWRVGLGLCFAWATFMVSGMMFVPESPRYLIEVGKDEEAKRSLSKSNKVSVDDPALLVEYDTIKAGIELEKLAGNASWSELLSTKTKVFQRVLMGVMIQSLQQLTGDNYFFYYGTTIFKSVGLKDSFQTSIIIGVVNFFSSFIAVYTIERFGRRTCLLWGAASMLCCFAVFASVGVTKLWPQGSSHQDITSQGAGNCMIVFTMFFIFSFATTWAGGCYVIVSETFPLRVKSRGMAIATAANWMWGFLISFFTPFITGAINFYYGYVFLGCLVFAYFYVFFFVPETKGLTLEEVNTMWLEGVPAWKSASWVPPERRTADYDADAIDHDNRPIYKRFFSS
Protein: Ornithine racemase (OR) (EC 5.1.1.12) (C1FW08)
Organism: Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / CCUG 9281 / NCIMB 10654 / HF) (Clostridium sticklandii)
Function: Involved in the ornithine fermentation pathway. Catalyzes the conversion of L-ornithine to D-ornithine. OR could also racemize basic amino acids such as lysine and arginine. Serine, asparagine and alanine could be also converted by OR, but at a lower rate.
Interaction partners:
- D-ornithine 4,5-aminomutase subunit beta
- D-ornithine 4,5-aminomutase subunit alpha
- Putative component of D-ornithine aminomutase
- 2-amino-4-ketopentanoate thiolase beta subunit
- 2-amino-4-ketopentanoate thiolase alpha subunit
- Alanine racemase domain protein
- 2,4-diaminopentanoate dehydrogenase
- Ornithine carbamoyltransferase
- Arginine deiminase
- Argininosuccinate lyase
Sequence:
MYPKITIDINKLRDNATFIKNLCEKGGCKTALVVKSMCANHDIVKELDSVEVDYFADSRIQNLKKLKDLKTKKMLLRIPMLCEVEDVVKYADISMNSELDTLKALNKAAKTLNKVHSVIIMVDLGDLREGYFEAEDLKENIKEIIKLENIEIKGIGVNLTCYGAVIPKNDNLSRLCDIADELRTEFNLELPIVSGGNSSSIYLIDKGELPEGITNLRVGESMLLGRETAYGEDIIGMNNDVFELKCQIVELKEKPSLPIGEIGVDAFGNKPYYEDKGIRKRAILAIGQQDTDISSLMPIDDKLEILGASSDHLIVDVSDSNTSYKVGDIITFRMGYGALLKGFTSEYIEKELL
Protein: N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2) (P15882)
Organism: Homo sapiens (Human)
Function: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Interaction partners:
- Homeobox protein Hox-A1
- Cytoplasmic protein NCK2
- Roundabout homolog 3
- Sal-like protein 4
- Cell division control protein 42 homolog
- Ephrin type-A receptor 4
- Ras GTPase-activating protein 1
Sequence:
MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF
Protein: Uncharacterized protein (Q38F77)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MMSKASYMMQDHLRRNFALITDIHNPNVFLVRGTLPFPQGLAVLTALFRGKLAADVYSHPYFIEKQSDPSQPSPQLHLTEECQSVMKIIKGMHFMNDTTSRLDNTVVFVSDYDVQVKATVLTYASEEDEDALLREQKRLEGESDEEWQGRLLRQRWQRSAAGRRKSGGNTGSSSFEASLRPFTRQSHHSNDGPDELGKAKRLVEREGAHTVLYNPIDVDPKTFVATINKLNDENRVVKTIVVPTRQAWGSVHAWAEAFPDAEILCSGEKPIPSGAQNRQQEVVRPTGGCMNMGNGLTGLSFPEVDEAEVAVGSAVDNDTEVAMVADDINNICRLCSSQPDSVSWRVADEEVRCSSRVQPLGTLIQKQITPNIELLRVAGDDLTNEYVMYDRNSASLACTDLFHGEYGDLDPVNSWLCRVWFKFMKQGNYKRVDRVPEFKWLQVKNHGDLKAVRESVDIITSMFPMKFLLYAHGTPPLAENPANALRLQWGMPPLS
Protein: AT4g00090/F6N15_8 (Transducin/WD40 repeat-like superfamily protein) (Q93ZN5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transcription initiation factor TFIID subunit 9
- Mitotic spindle checkpoint protein MAD2
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 2
- Anaphase-promoting complex subunit 6
- Protein ANTHESIS POMOTING FACTOR 1
Sequence:
MDSVLVVGIASVILGALIAVLFFGSYFRKRTSEVQSMAKAEPQDPIRNPKSNHPAPKKNHPKSQASDKNQNKRHHPLDLNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDASSKSFKFLRINLPAGGHPTAVAFADDASSIVVACHHMSGSSLYMYGEDKQKDQQGKLPLPSIKWDHHHIHEKRSVLTISGATATYGTADGSVVIASCSEGTDIVLWHGKTGRNLGHVDTNQLKNHMAAVSPNGRFLAAAAFTADVKVWEIVYQKDGSVKEVSRVMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWNINVRYHLDEDPKTLKVFPIPLCDSGGNPLHYDRLSLCPEGKILAASHGSTLQWLCAETGNVLDTAEKAHEGDITCISWAPKAITVGERHAMVLGTSGDDKKVKLWEAPKSQSL
Protein: Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8) (Q9VKH0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for normal Golgi function.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 7
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 4
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 2
- Conserved oligomeric Golgi complex subunit 5
- Vacuolar protein sorting-associated protein 53 homolog
- Vacuolar protein sorting-associated protein 52 homolog
- Syntaxin-5
Sequence:
MDFPDKMDLENERVLKLIFPDGVPDNLRGNPELDNYLAKLGTCKVEQLKKEQTRLAEEARTILEQTQDLAISNYRTFITTAENSRSIFSEFLRSEQQLDTLVSKLPDLSVQCERFLQDSAELNEQRRLNSITLQKNAQLLEVLELPQLMERCIREGRYEEALELAAYATRLGQHQGHIPVVTSIVRSVEALWHNMLVQLVAQLRTDLQLPKCLQIVGYLRRMQAFGDNELRLKFLQARDAWLTSCLEAIPTADAQQHLSKTIEITRINLFNIITQYRAIFPEDEGTLKTQSSLRPLQGVSCNGDRLFQAWLHNKISDFLQTLERDLQLGVGSVETVLGQCMYFGLSFSRVGADFRALMAPIFVGVIRRRFESSVEQVDEQFERELERFTLINKVALHSHARKQVDPEQESYAPPEALLDFYPLAALCNGYLSALNELRLCAPLALATDVTRCLQHSLQQAAQRVLAFYRQEQQAFAGSEREAFVRLCSCLAYDLVPYIQRCIHGVFPPQSLTVHLGISLLQLEQQQLTYLQQTRILEPLKHLLPTKALVQPQDKVMEAKPSAGVPVTAEG
Protein: Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Glucokinase-associated dual specificity phosphatase) (GKAP) (Q9JIM4)
Organism: Rattus norvegicus (Rat)
Function: Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9UNI6}. Cytoplasm {ECO:0000269|PubMed:10913113}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9UNI6}. Note=Primarily nuclear. Detected in a mesh-like pattern in the cytosol. {ECO:0000250|UniProtKB:Q9UNI6}.
Interaction partners:
Sequence:
MLEVQSSNHGCERQAPTTSPASSAGHAVEVRPGLYLGGAAAVAGPDYLREAGITAVLTVDSEPAFPAGAGFEGLQSLFVPALDKPETDLLSHLDRCVAFIGQARSEGRAVLVHCHAGVSRSVAVVTAFIMKTEQLTFEKAYENLQTIKPEAKMNEGFEWQLKLYEAMGHEVHTSSAVYKQYRLQKVTEKYPELRNLPRELFAVDPTTVSQGLKDDILYKCRKCRRSLFRRSSILDHSEGSGPVAFAHKRTGLSSVLTTGNQAQCTSYFIEPVQWMESALLGVMDGQLLCPKCSAKLGSFNWYGEQCSCGRWITPAFQIHKNRVDEVKTLPALGSQTKKP
Protein: Selenoprotein S (SelS) (Minor histocompatibility antigen H47) (Q9BCZ4)
Organism: Mus musculus (Mouse)
Function: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Transitional endoplasmic reticulum ATPase
- Selenoprotein K
- Derlin-1
- Selenoprotein F
- Thioredoxin reductase-like selenoprotein T
- Protein adenylyltransferase SelO, mitochondrial
- E3 ubiquitin-protein ligase synoviolin
- Selenoprotein M
- Selenoprotein N
- Derlin-2
Sequence:
MDRDEEPLSARPALETESLRFLHVTVGSLLASYGWYILFSCILLYIVIQRLSLRLRALRQRQLDQAETVLEPDVVVKRQEALAAARLRMQEDLNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGRSYKRNSGRPQEEDGPGPSTSSVIPKGKSDKKPLRGGGYNPLTGEGGGTCSWRPGRRGPSSGGUN
Protein: Uncharacterized protein (Q8BLZ1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLLVPMDSPGITVIRPLSVFGLEDPPGGFAEVQFKDVRVPKENIILGPGRAFEIAQGRLGRARIHNSMRLIGYSERALALMKTRVSPPVPTLTQTHCCWLRNSNHWSPLRTELTGQCPCLESASLFCMYFTWLQLASRVGWAPLCLGGQKPRAGFMVAEGKVLNPRGLWQPGTICSQHI
Protein: Polynucleotidyl transferase, ribonuclease H fold protein with HRDC domain-containing protein (F4HWX0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MRFDDPMDEFKRNRKMEEDSKKVIDVKVAESDKGFAKFGKAEVPFHIPTLTKPQEEYKILVDNANNPFEHVLLEKSEDGLRFIHPLEELSVMDFVDRNLSEMRPVKPLPLEETPFKLVEEVKDLEDLAAALQSVEEFAVDLEHNQYRTFQGLTCLMQISTRTEDYIVDIFKLWDHIGPYLRELFKDPKKKKVIHGADRDIIWLQRDFGIYVCNLFDTGQASRVLKLERNSLEFLLKHYCGVAANKEYQKADWRIRPLPDVMKRYAREDTHYLLYIYDVMRMELHTMAKEDEQSDSPLVEVYKRSYDVCMQLYEKELWTRDSYLHVYGVQTGNLNAVQLSIVAGLCEWRDRIARADDESTGYVLPNKTLFDIAKEMPIVVAQLRRLLKSKLPYLERNFDAVISVIRRSMQNAAAFEPVVQSLKDRRPETVVEMNIEPKIEKTDTGASASSLSLEKVCVDDSKKQSSGFGVLPLKRKLESDKTVVEKNIEPKIEKTGTEASASSLSSKKVCVDDSKKQSSGFGVLLSKRKFESDNKLQVKEEVKVSKSKPDKVIIVVDDDDDDDDDESYEQSTKAADALDRVSETPSKGSPSLTQKPKTCNTEVIVLDDDDDSESREDEDMRRRSEKHRRFMNMKRGFLNI
Protein: BRANCHED1A isoform 1 (L0AR29)
Organism: Chrysanthemum morifolium (Florist's daisy) (Dendranthema grandiflorum)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHPSFSSFRLYNPHYNPLEDPLIAHELFDTQRQQSFTNDHNYHCTFMVAQENSALSNTNVHSTMNNSSCKNGKFIALDGGNRGLTDNRSFKKDRHSKINTARGPRDRRMRLSLDVAKKFFKLQDMLGFDKASNTIEWLIMKSKPSIRDLLTEHLYQSCSLMGVSNSASSASECEVLSGLNDDQSTDKTVEDQGIAVNKEKKKRDKVVRRCVYVDHSIAKETREKARVRARKRTAEKRKIKLGNASCLDHVMLQNMSRLGSWIPFGEHQVQTIDQAEYASSYFQFKQGINVGDTSSATSSNWNPSLFNHQQNIGISHEHQFSDFQIPGRPWECMSK
Protein: Probable bifunctional chitinase/lysozyme [Includes: Chitinase (EC 3.2.1.14); Lysozyme (EC 3.2.1.17)] (P13656)
Organism: Escherichia coli (strain K12)
Function: Bifunctional enzyme with lysozyme/chitinase activity.
Subcellular location: Periplasm {ECO:0000269|PubMed:10760150}. Note=Secreted via the Gsp type II secretion machinery under conditions of derepressed gsp gene expression.
Interaction partners:
- N-acetyl-D-glucosamine kinase
- Beta-hexosaminidase
Sequence:
MKLNIFTKSMIGMGLVCSALPALAMEAWNNQQGGNKYQVIFDGKIYENAWWVSSTNCPGKAKANDATNPWRLKRTATAAEISQFGNTLSCEKSGSSSSSNSNTPASNTPANGGSATPAQGTVPSNSSVVAWNKQQGGQTWYVVFNGAVYKNAWWVASSNCPGDAKSNDASNPWRYVRAATATEISETSNPQSCTSAPQPSPDVKPAPDVKPAPDVQPAPADKSNDNYAVVAWKGQEGSSTWYVIYNGGIYKNAWWVGAANCPGDAKENDASNPWRYVRAATATEISQYGNPGSCSVKPDNNGGAVTPVDPTPETPVTPTPDNSEPSTPADSVNDYSLQAWSGQEGSEIYHVIFNGNVYKNAWWVGSKDCPRGTSAENSNNPWRLERTATAAELSQYGNPTTCEIDNGGVIVADGFQASKAYSADSIVDYNDAHYKTSVDQDAWGFVPGGDNPWKKYEPAKAWSASTVYVKGDRVVVDGQAYEALFWTQSDNPALVANQNATGSNSRPWKPLGKAQSYSNEELNNAPQFNPETLYASDTLIRFNGVNYISQSKVQKVSPSDSNPWRVFVDWTGTKERVGTPKKAWPKHVYAPYVDFTLNTIPDLAALAKNHNVNHFTLAFVVSKDANTCLPTWGTAYGMQNYAQYSKIKALREAGGDVMLSIGGANNAPLAASCKNVDDLMQHYYDIVDNLNLKVLDFDIEGTWVADQASIERRNLAVKKVQDKWKSEGKDIAIWYTLPILPTGLTPEGMNVLSDAKAKGVELAGVNVMTMDYGNAICQSANTEGQNIHGKCATSAIANLHSQLKGLHPNKSDAEIDAMMGTTPMVGVNDVQGEVFYLSDARLVMQDAQKRNLGMVGIWSIARDLPGGTNLSPEFHGLTKEQAPKYAFSEIFAPFTKQ
Protein: Phospholamban (PLB) (P61014)
Organism: Mus musculus (Mouse)
Function: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26816378, ECO:0000269|PubMed:27923914, ECO:0000269|PubMed:30733280}; Single-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P26678}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:A4IFH6}; Single-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:20890288}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with HAX1 at the endoplasmic reticulum. Colocalizes with DMPK at the sarcoplasmic reticulum. {ECO:0000250|UniProtKB:P26678}.
Interaction partners:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- cAMP-dependent protein kinase catalytic subunit alpha
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
- cGMP-dependent protein kinase 1
- cAMP-dependent protein kinase catalytic subunit beta
- cGMP-dependent protein kinase 2
- Plasma membrane calcium-transporting ATPase 4
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Sequence:
MEKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLILICLLLICIIVMLL
Protein: m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) (Q96C86)
Organism: Homo sapiens (Human)
Function: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.
Interaction partners:
- NADPH-dependent diflavin oxidoreductase 1
- m7GpppN-mRNA hydrolase
- 5'-3' exoribonuclease 1
- Eukaryotic translation initiation factor 4E
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS