wanglab/gogpt-training-data huggingface dataset:
Protein: Autophagy-related protein 21 (Cytoplasm to vacuole transport protein 21) (Homologous with SVP1 protein 1) (Maturation of proaminopeptidase I protein 1) (Q02887)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage. Essential for maturation of proaminopeptidase I.
Subcellular location: Cytoplasm. Vacuole. Note=And perivacuolar punctate structures.
Interaction partners:
- Autophagy protein 16
- Autophagy-related protein 9
- Autophagy-related protein 2
- Autophagy-related protein 18
- Ubiquitin-like protein ATG12
- Autophagy-related protein 8
- Vacuolar protein sorting-associated protein 30
- Sorting nexin-4
- Autophagy-related protein 19
- Ubiquitin-like modifier-activating enzyme ATG7
Sequence:
MKVLQFNQDATCCVVAASSHQISIFNCDPFGKCFEIDTKNSKKKTSNNNGSASNSESRNNEESILITNGSRDRTDAEEEEDNEDNALVTGNILKEGEFVIEMLFSTSLIAIADRGQGLNKGKKLKIVNTKRKCTICEIVFPHEIVDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYKRSQANSFSNASNTGTLEGDSANLNRVATNLLANATQKSVNGSNPSVRTRRNSLRSKIRPRMVLSNDDRSILCFTAYSSPKKNKPNSEALYDVVIYDTLNVTPVNYLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRGTRLCNLYQLAFDKSMTMIGCVGDTDTIHLFKLDDASNSLPGDNSSNGHWNEEEYILASNSNPSMGTPKEIPLSKPRIANYFSKKIKSSIPNQNLSRNFAYITVNESNRSCLGFPDEFPNQVYIASDDGTFSIYSIPSKPGECVLTKNNKFT
Protein: Protein CDV3 homolog (Q9UKY7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MAETEERSLDNFFAKRDKKKKKERSNRAASAAGAAGSAGGSSGAAGAAGGGAGAGTRPGDGGTASAGAAGPGAATKAVTKDEDEWKELEQKEVDYSGLRVQAMQISSEKEEDDNEKRQDPGDNWEEGGGGGGGMEKSSGPWNKTAPVQAPPAPVIVTETPEPAMTSGVYRPPGARLTTTRKTPQGPPEIYSDTQFPSLQSTAKHVESRKDKEMEKSFEVVRHKNRGRDEVSKNQALKLQLDNQYAVLENQKSSHSQYN
Protein: Probable diguanylate cyclase CdgI (DGC) (EC 2.7.7.65) (P76236)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable diguanylate cyclase DgcI
- Probable cyclic di-GMP phosphodiesterase PdeG
- Probable cyclic di-GMP phosphodiesterase PdeK
- Cyclic di-GMP phosphodiesterase PdeH
- Probable cyclic di-GMP phosphodiesterase PdeN
- Cyclic di-GMP phosphodiesterase PdeF
- Probable cyclic di-GMP phosphodiesterase PdeI
- Diguanylate cyclase DgcP
- Cyclic di-GMP phosphodiesterase PdeL
- Probable cyclic di-GMP phosphodiesterase PdeC
Sequence:
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFIFSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILPTLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFCYGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGINYTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRGIEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCVMLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQAKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKSEGGNKVIIHHI
Protein: Protein TIFY 11c (OsTIFY11c) (Jasmonate ZIM domain-containing protein 11) (OsJAZ11) (OsJAZ2) (Q8GRS2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Repressor of jasmonate responses.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Transcription factor MYC2
- Os10g0506950 protein
- Coronatine-insensitive protein homolog 1a
- Coronatine-insensitive protein homolog 1b
- Coronatine-insensitive protein homolog 2
- Protein TIFY 9
Sequence:
MAGSSEQQLVANAAATTVAGNGSRFAVTCGLLRQYMKEHSGSNGGGGFLPAVTAMSLMTGGADAEEEAPEVRKTMELFPQQAGTLKDTQERKEITEKAQLTIFYGGSVVVFDDFPAEKAGELMKLAGSRDSTAAAAVSDAGAAAGQPCLPDMPIARKVSLQRFLEKRKNRIVVAEPLPESEKKEAESSKRAKKDDGGASWLQVNPTLSL
Protein: ELYS-like domain-containing protein (Q5B4D4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nuclear pore complex protein An-Nup133
- Nuclear pore complex protein
- Protein transport protein sec13
- WD40 protein related to S. cerevisiae SEH1
- Nuclear pore complex protein An-Nup170
- Nuclear pore complex protein An-Nic96
- Nuclear pore complex protein AN-Nup192
- Peptidase S59 domain-containing protein
- Nuclear pore complex protein An-Nup49
- Nucleoporin NSP1
Sequence:
MASWEEFDAIFYFNKNFTYDGKVIEQILSNRRALDNRLFADRLLELLGVQAVTKLYPPISNSDLRTLIRHIVSSELDAHQKQSLIYYILKDCRAPSDVAAQFARRCHLPEKYRLFIEGLWNLDRLEFKRAIEYLSEPSIIPTFPDEILYALTLSHLPRHDDSLVMAYYLTVNPPLTSEKAQRAFMETLCRASITEAFYFTRKHHEALRQAYLTQLIEFVHRTDAGQMRSRRAMELIGLPFDDQEEQWFEDALLRGSAKTLHGAKDTVMARRLATGKVAGLSAELESLDGKKIDGLNWDLLKQSMKPPLNSADRGQSQ
Protein: Nuclear receptor subfamily 2, group F, member 1 (A0A8I6A7N1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MAMVVSSWRDPQDDVQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS
Protein: L-2,3-butanediol dehydrogenase (L-BDH) (EC 1.1.1.76) ((S,S)-butanediol dehydrogenase) (Diacetyl reductase [(S)-acetoin forming]) (EC 1.1.1.304) (Q9ZNN8)
Organism: Corynebacterium glutamicum (Brevibacterium saccharolyticum)
Function: Catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol (L-BD) in the presence of NADH. To a lesser extent, can also catalyze the irreversible reduction of diacetyl to (S)-acetoin. Cannot oxidize meso-BD, D-BD, 2-butanol, 1,2-propanediol, ethanol, acetol, 1,2-butanediol, 1,3-butanediol, n-butanol, and n-propanol. Cannot reduce (R)-acetoin, acetol, dihydroxyacetone and 2,4-pentanedione.
Interaction partners:
Sequence:
MSKVAMVTGGAQGIGRGISEKLAADGFDIAVADLPQQEEQAAETIKLIEAADQKAVFVGLDVTDKANFDSAIDEAAEKLGGFDVLVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGIQAASRKFDELGVKGKIINAASIAAIQGFPILSAYSTTKFAVRGLTQAAAQELAPKGHTVNAYAPGIVGTGMWEQIDAELSKINGKPIGENFKEYSSSIALGRPSVPEDVAGLVSFLASENSNYVTGQVMLVDGGMLYN
Protein: Complement C8 gamma chain (D3ZPI8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Complement C8 alpha chain
- Complement component C8 beta chain
- Complement component C6
- Complement component C9
- Complement C7.
- Complement C5
- ADP/ATP translocase 2
- Lipocln_cytosolic_FA-bd_dom domain-containing protein
- ADP/ATP translocase
- ADP/ATP translocase 1
Sequence:
MLQGPERHFAGTWLLVAVGSACRFLQEQGHRAEATTLHIAPQGAAMAASTFRKLDGICWQVRQLYGITGVPGRFLLQAPRARGPVHVVVAETDYQSFAILYLEQARRLSVKLYTRTLPVSDSALNAFEERVRGANLTEDQIFFFPKYGFCETADQFHILNEMPK
Protein: F7A19.25 protein (RNA-binding KH domain-containing protein) (Q9XI71)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g14430
- Nuclear cap-binding protein subunit 2
- non-specific serine/threonine protein kinase
- Nuclear cap-binding protein subunit 1
- U6 snRNA phosphodiesterase
- RGG repeats nuclear RNA binding protein A
- Probable protein phosphatase 2C 51
- Sm-like protein LSM3B
Sequence:
MASTLRNIHGKRSNLQSEFTGNGGSKRRNLHDETDQNVIASEDTVYRYLCPVKKTGSIIGKGGEIAKQIRSETKSNMRINEALPGCEERVVTMYSTNEELNHFGDDGELVCPALDALFKVHDMVVADADQDDGTDDDNDLGEKQTVTVRMLVPSDQIGCVIGKGGQVIQNLRNDTNAQIRVIKDHLPACALTLSHDELLLIIGEPLVVREALYQVASLLHDNPSRFQHLLLSSSSSSMHQPGAMLMSAALTSSHRNYAVRRDIADAREFCVCFICPAENVGGVIGKGGGFINQIRQETGATIRVNTSETDDDDCIIFISSKEFYEDQSPAVNAAIRLQQRCSEKVGKDANDLAISTRLLVSSSQIGCLIGKGGAVISEMRSVTRANIRILQKEDVPKIAREDEEMVQITGSPDAAMKALTQVILRLRANSFDMDHGLVLLPTSFPYIPQVTESSSKSKYAKRDDHSKLNSNSKRRNHVS
Protein: Protein STRICTOSIDINE SYNTHASE-LIKE 7 (AtSSL7) (Q9SD04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Vacuole {ECO:0000250}.
Interaction partners:
- Farnesoic acid carboxyl-O-methyltransferase
- AT2G01100 protein
- Pathogenesis-related thaumatin superfamily protein
- Protein DETOXIFICATION 18
- Nudix hydrolase 8
- Methylesterase 3
Sequence:
MPVLFSSRSLILSIIVPLLISIALYKLDTFDPAIVPSDAFTSSATSLPPLINDEFLTGAEFIGVGLLNIPEDIAYHKESNLIYTGCVDGWVKRVKVADSVNDSVVEDWVNTGGRPLGIAFGIHGEVIVADVHKGLLNISGDGKKTELLTDEADGVKFKLTDAVTVADNGVLYFTDASYKYTLNQLSLDMLEGKPFGRLLSFDPTTRVTKVLLKDLYFANGITISPDQTHLIFCETPMKRCSKYYISEERVEVFTQSLPGYPDNIRYDGDGHYWIALPSGVTTLWNISLKYPFLRKLTAMVAKYGVDLMFMENAGVLQVDLDGNPIAYYHDPKLSHIATCDKIGKYLYCGSLSQSHILRLDLLKYPAQNKKL
Protein: Heat shock protein 25 (Q6BDR9)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MLCRMHLAPFASSSLATRLGTVRTLWPHAETIFSELQQEMEKARQFMSSFEQLLSSHGPIAAEQAPSSSAAPAQGSGEGFSVCQDVKNFAPEQLSVKVVGRKVVLVGQKETQNTDEKGSFSYKYEVLKREWDVPEEVDAEALTCSPVPGGSCASRPPGWPCRLLLRGVCPSR
Protein: Transferrin-a (Q6P3G0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MPVERAVSEFFSSSCVPGVSKPKYPNLCKACQGDCSCSHNEKYFGDDGAFQCLKNDNGQVAFVCHHAIPESERQNYELLCMDGSRKSVEDYKTCNFAREPARTVIARTDTDLQYVYDVLKQIPASDLFSSQAFGGKDLIFSDSATELMLLPKRTDSLLYLKEEYYEAMQAFKDGNPSAPTSQTKLAMCTIGHAEKNKCDSLDHVKKSCILEASVDDCIEKIKRKEADFLAVDGGQVYIAGKCGLVPVMAEQSNSQSCSSGSGGTASYYAVAVVRKGSGLTWNNLEGKKSCHTGLGRSAGWKIPESAICGEKDKCTLDKFFSEGCAPGADPTSNMCKLCKGSGKPVGDESKCKPSAEEQYYGYDGAFRCLAEKAGDVAFIKHTVVGDYTDGKGKDWAKDLKSEDFELICPNTPDTTMKYTDFEKCNLAQVPVHAVITREDARSAVVSFLSDIQSKNNDLFTSKDGKNLLFTDGTKCLQEIKGSVDDFLTKKYIDMIERTYKTSQNVPDLVKACTFGNCISS
Protein: UBX domain-containing protein 4 (Erasin) (P34631)
Organism: Caenorhabditis elegans
Function: Probably acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. May play a role in the ER-associated protein degradation pathway (ERAD) possibly acting as a platform to recruit both ubql-1 and cdc-48.1 and/or cdc-48.2 to the ER during ERAD.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92575}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q92575}. Note=Both the N- and the C-terminus face the cytosol. {ECO:0000250|UniProtKB:Q92575}.
Interaction partners:
- UBX domain-containing protein 6
- UBX domain-containing protein 2
- Transitional endoplasmic reticulum ATPase homolog 2
- Transitional endoplasmic reticulum ATPase homolog 1
- ATPase family protein 2 homolog
- UBX domain-containing protein 1
- TUG ubiquitin-like domain-containing protein
- Ubiquitin conjugation factor E4 ufd-2
- UBX domain-containing protein 5
- Ubiquilin
Sequence:
MQWFGGNVATAIQISRKNKALLIVYITTDSEDGQIFDGFWQHIDSSNLLCAVVGIKLKAGETSAQQFADIYPTPILPAAYLIDQNGKPLEVITPLVGKTYDQFRAKFDKATAQFVNGMPTAAANQLSTPSPSPAPVQVPASTDAPIPAPTPVTAPIQSSSTSQEMTRELAEKVARAKALLEQKKQKDAEKKREADKHVKEEMTKAREAKQERDAEALVKAAKQRKMEKLAAESDKKRILAQIKADREAAQKKFGKLVNTENASENTEKKQETTVGKAVPSDRCRLQVRLPDGSTFVEEFPSNDVLNSLVEIIRQKPSIAGTTFEIQQPYPRRIFTNDDYSKTFLENQLTPSTALVVIQKSSGSSSNYGSFSLSTQTVSFVTWVLYPLTAFWNIFCGMIGWNSTGKQQDSKSKKNDGPSTSGQSGSQPQRRGMPRSAEVRRRGNVAGLENPNEDDPEERASFNGNSTQFM
Protein: Angiopoietin-1 (ANG-1) (O35460)
Organism: Rattus norvegicus (Rat)
Function: Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
Subcellular location: Secreted {ECO:0000250|UniProtKB:O08538}.
Interaction partners:
- Angiopoietin-1 receptor
- Tyrosine-protein kinase receptor Tie-1
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 1
- Angiopoietin-2
- Platelet-derived growth factor receptor beta
- Angiopoietin 4
- Vascular endothelial growth factor receptor 3
- High affinity nerve growth factor receptor
- Macrophage colony-stimulating factor 1 receptor
Sequence:
MTVFLSFAFFAAILTHIGCSNQRRSPENGGRRYNRIQHGQCAYTFILPEHDGNCRESATEQYNTNALQRDAPHVETDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYELEKQLLQQTNEILKIQEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTFIIQELEKQLSRATSNNSVLQKQQLELMDTVHNLVSLCTKEVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYFNNMPEPKKVFCNMDVNEGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNQKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF
Protein: Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2) (P55937)
Organism: Mus musculus (Mouse)
Function: Plays an important role in spermatogenesis and/or testis development. Probably identical with the serologically detectable male antigen (SDM). Probably involved in maintaining Golgi structure.
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Golgi-associated PDZ and coiled-coil motif-containing protein
- Golgi resident protein GCP60
- Golgi reassembly-stacking protein 1
- Golgin subfamily A member 7
- Golgin B1
- Thyroid hormone receptor interactor 11
Sequence:
MDGASAKQDGLWESKSSSDVSSCPEASLETVGSLARLPDQQDTAQDASVEVNRGFKEEGSPDRSSQVAICQNGQIPDLQLSLDPTTSPVGPDASTGVDGFHDNLRNSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTASSLPLEKEEQVRLQARKRLEEQLMQYRVKRHRERSSQPATKMKLFSTLDPELMLNPENLPRASTVAVTKEYSFLRTSVPRGPKVGSLGLLAHSKEKKNSKSSKIRSLADYRTEDPSDSGGLGSTADAVGSSLKQSRSSTSVVSEVSPSSETDNRVESASMTGDSVSEADGNESDSSSHSSLSARGACGVLGNVGMPGTAYMVDGQEISAEALGQFPSIKDVLQAAAAQHQDQNQEANGEVRSRRDSICSSVSMESSLAEPQDELLQILKDKRRLEGQVEALSLEASQALQEKAELQAQLAALSTRLQAQVEHSHSSQQKQDSLSSEVDTLKQSCWDLGRAMTDLQSMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRNILSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLQASQAEITSLQHARQWYQQQLTLAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSHQLTETQHRSIKEKERIAVQLQSIEADMLDQEAAFVQIREAKTMVEEDLQRRLEEFEGEREQLQKVADAAASLEQQLEQVKLTLFQRDQQLAALQQEHLDVIKQLTSTQEALQAKGQSLDDLHTRYDELQARLEELQREADSREDAIHFLQNEKIVLEVALQSAKSDKEELDRGARRLEEDTEETSGLLEQLRQDLAVKSNQVEHLQQETATLRKQMQKVKEQFVQQKVMVEAYRRDATSKDQLINELKATKKRLDSEMKELRQELIKLQGEKKTVEVEHSRLQKDMSLVHQQMAELEGHLQSVQKERDEMEIHLQSLKFDKEQMIALTEANETLKKQIEELQQEAKKAITEQKQKMKRLGSDLTSAQKEMKTKHKAYENAVSILSRRLQEALASKEATDAELNQLRAQSTGGSSDPVLHEKIRALEVELQNVGQSKILLEKELQEVITMTSQELEESREKVLELEDELQESRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVQALQVSLEKEKMEVNSLKEQMAAARIEAGHNRRHFKAATLELSEVKKELQAKEHLVQTLQAEVDELQIQDGKHSQEIAQFQTELAEARTQLQLLQKKLDEQMSQQPTGSQEMEDLKWELDQKEREIQSLKQQLDLTEQQGKKELEGTQQTLQTIKSELEMVQEDLSETQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKKKEPKGESNSSSPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNNCLQQLKQEMDSLQRQMEEHTITVHESLSSWAQVEAAPAEHAHPRGDTKLHNQNSVPRDGLGQ
Protein: Regulator of G-protein signaling 18 (Zgc:153888) (Q08BE2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Solute carrier family 43 member 3b
- SH3-domain-binding protein 5b
- trypsin
- Tumor necrosis factor, alpha-induced protein 8-like protein 2 B
Sequence:
MRSEDEQLACRMKETHLRSKDKKGRLSLLLARSGSHENVSPDKKPQAKSNHIPPDVAMKWSDSFEDLLSHSDGVEVFTRFLRTEFSEENIEFWLACEDFKTTESSTKLQTKAKQIHAIFIDKEAPKEINIDHSTKAAIEKNILQPTNSCFDAAQHKIYGLMKRDCYPRFLASDIYLTLTKRSGPPTMTRRRSRSFVFNERPEGTAAWL
Protein: Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) (Q9Y696)
Organism: Homo sapiens (Human)
Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14569596}. Cytoplasmic vesicle membrane {ECO:0000305|PubMed:17636002}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000305|PubMed:17636002}. Cell membrane {ECO:0000269|PubMed:18302930}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250|UniProtKB:Q9Z0W7}. Cell junction {ECO:0000269|PubMed:14569596}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z0W7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Z0W7}. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:14569596}.
Interaction partners:
- Transcription factor HIVEP2
- Taperin
- Chloride intracellular channel protein 5
- Chloride intracellular channel protein 2
- Chloride intracellular channel protein 6
- Histamine H3 receptor
- Protein phosphatase 1A
- Ezrin
- Mothers against decapentaplegic homolog 3
Sequence:
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK
Protein: Reticulon-3 (Q6RJR6)
Organism: Rattus norvegicus (Rat)
Function: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O95197}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O95197}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Beta-secretase 1
- Reticulon-4
- Beta-secretase 2
- Atlastin-3
- Translocation protein SEC62
- Cell cycle progression 1
- Atlastin-1
- Reticulophagy regulator 1
- Testis expressed gene 264 homolog
Sequence:
MAESSAATQSPSVSSSSSGAEPSTLGGGGGSPGACPALGAKSCGSSCAVGLSSLCSDEPPSKIMTSSFLSSSEIYNPDPTTPLGSETLGSHLVAKDGKDPLVLLDKKTLDSPQGTNKDRVDTPVSLAADIPCSHPSIPDSFPEQPTFLSKETDPTEEWVVKNQEPKNPSEVPSGEDRSALDLGQRKAEHICTHSLSPSEPAVASVEKDSPESPFEVIIDKATFDREFKDLYKESTDDLGGWAAHGDRESPADLLEMNDKVFPLRNKEAGRYPSSALLGRQFSHTTAALEEVSRCVNDMHNFTNEILTWDLDPQAKQQADKSPCTTESTGLDRSEHRSEIPVINLKTSPQQKMPVCSFNGSTPITRSTGDWTETFTEGKPVKGYLSSTKEAGGKGVPDSSQPISGSGAATVEVTLPDLRGTWPNSVLGEVTEVDSSGESDDTVIEDTTENPSVKNNKVLPEKSDSLPSAAVKTSERENKETTSHETVRSEMYENSEQQQAHAETPTQRSLEGQMSPQVPNMLNEVIPENLAMTDTTRVCSAAPPSVLSETGFSLTVPASAKSESLLGKNVEDTDGSSPEDLMAALTGTEEKGTVDKEKGDVLEAVLEKIANVKNTLPVELLHENKLSSSETKNTKSKYSEHSRETNGGAPKVSSDLEQEQLTIRAIKELGAKQVQAERMSPGGKLKRTFDPQSGPQNSSDILEHTDITTGSDLGIPKKPTIIKDTRIDSISSLTKTETVNKHVLARLLSDFPVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRVYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHSYMNAAMVHVNKALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLVFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE
Protein: Secretoglobin family 3A member 1 (Cytokine HIN-1) (High in normal 1) (Pneumo secretory protein 2) (PnSP-2) (Uteroglobin-related protein 2) (Q96QR1)
Organism: Homo sapiens (Human)
Function: Secreted cytokine-like protein. Inhibits cell growth in vitro.
Subcellular location: Secreted {ECO:0000269|PubMed:11481438}.
Interaction partners:
- Uteroglobin
- BPI fold-containing family B member 1
Sequence:
MKLAALLGLCVALSCSSAAAFLVGSAKPVAQPVAALESAAEAGAGTLANPLGTLNPLKLLLSSLGIPVNHLIEGSQKCVAELGPQAVGAVKALKALLGALTVFG
Protein: Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) (Q7K579)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Phosphatidate cytidylyltransferase, photoreceptor-specific
- Phospholipase
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- GM01519p
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
- FI05338p
- GH11618p
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
- O-acyltransferase
Sequence:
MDIGTIELSVEALIGSLLALSILFAFCRSLLSEDFVSTFKTRHSWKSIKVLEQACFCNVCEILLTPSAGLFCDCCGLCTHATPPCQRRADREYRCKDKWLRNESSVRHLWVHGNLPMGVHCADCNEEVDHHVSTDPGLYGWRCAWCQRCYHNDCYTRADSMEACDLGEFKDMIFPPYSFVAARTRDSMRLHLASITPPDIENWEPLIVIANTKSGSSTGANVLSLLRGYLHPLQVMELGSRGPQDALQWAAKASPRPCRILVAGGDGTIGWVLNTIYTLNIKPQPSVAIMPLGTGNDLSRVLGWGAEPPSVLDPVKILRSIRRARSVNLDRFDLQIEKLHYRLPIQRHPTKTIHVYNYFSVGVDAYITYNFHKTRESRFYLLSSRIFNKLLYFTFGTQQVMQPGCEHIEEKLTLYLDNKPVQLPELQALVFLNIDSWGAGCKLCELSNANGEVRIVNSISDGMMEVFGIVSSFHIAQLQCNISKPVRIGQAKQIRLQVKETVPMQADGEPWMQSPADIRLSSRSQARVLKLAAT
Protein: Glypican-3 [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit] (Q8CFZ4)
Organism: Mus musculus (Mouse)
Function: Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity). Positively regulates the non-canonical Wnt signaling pathway. Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression. Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4. Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis. Required for coronary vascular development. Plays a role in regulating cell movements during gastrulation (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P13265}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P13265}; Extracellular side {ECO:0000250|UniProtKB:P13265}.
Interaction partners:
- Protein Wnt-3a
- Insulin-like growth factor 2
- Protein Wnt-5a
- Protein Wnt-2
- Sonic hedgehog protein
- Indian hedgehog protein
- Protein Wnt-7b
- Protein Wnt-4
- Netrin receptor UNC5D
- Proto-oncogene Wnt-3
Sequence:
MAGTVRTACLLVAMLLGLGCLGQAQPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQMMNPGLPESVLDINECLRGARRDLKVFGSFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNGGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKILKVAHVEHEETLSSRRRELIQKLKSFINFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSVPKGKVLDKSLDEEGLESGDCGDDEDECIGSSGDGMVKVKNQLRFLAELAYDLDVDDAPGNKQHGNQKDNEITTSHSVGNMPSPLKILISVAIYVACFFFLVH