wanglab/gogpt-training-data huggingface dataset:
Protein: Na(+)/H(+) exchanger protein 2 (Na(+)/H(+) antiporter nhx-2) (Q8T5S1)
Organism: Caenorhabditis elegans
Function: Na(+)/H(+) antiporter that promotes normal di- or tripeptide transporter function, recovery following the peptide-induced acidification of the intestinal cytoplasm and maintenance of the peptide-dependent intestinal pH homeostasis. Regulator of free fatty acid uptake from the diet together with the dipeptide transporter pept-1. May play a timekeeper role in defecation cycle but is not necessary for pbo-4-dependent proton release. May play a role in the regulation of lifespan independent of the stress response pathway.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:12021279, ECO:0000269|PubMed:12939266}; Multi-pass membrane protein {ECO:0000269|PubMed:12021279, ECO:0000269|PubMed:12939266}; Lumenal side {ECO:0000269|PubMed:12021279, ECO:0000269|PubMed:12939266}. Note=Colocalizes with pept-1 along the apical membrane of the intestinal cells. {ECO:0000269|PubMed:12021279, ECO:0000269|PubMed:12939266}.
Interaction partners:
- Peptide transporter family 1
- EF-hand domain-containing protein
- V-type proton ATPase 116 kDa subunit a 3
Sequence:
MSLLRRPWVLVVGLLLIMSYVGAECEEEEKEYPSRYPIAYFEWENVKIPMTICLWLIGASIAKIIFNLIPHLNELFPDSALLIMIGLIIGIIFKLIGVNKNAFFLESEVFMLYLLPPLVFDAGYFMPARQFFDNFGSILCFAMIGTSFNIVAIALSLWAISLTGLFSVETPLMHMLLFGSVAADVDPVAVIVIFEELKVNEVLFIAVFGESLLNDGVAVVLYRMFLTFSEIGTENLITSDYINGGVSFLVVAFGGIGIGLLFAFLTSLVTRFARDEEVKVLNSVFILILPYTCYLCGELFGLSSIMAIVFCGAAMRQYCRENVDPDTVKATESFIKVLSLASETVIFVFLGLSTVSSNHHWDTSFIVLTVVFCLIYRTLGVVVMCYFLNKYRLNKYTKVDQFIMAYGGLRGAIAYGLVVAIPDFIPGKNMFVTSCIIVIYFTVFLQGITLKPIAEFLQVEKKNVHSKNMIEHIYSELIDTTMAGMEDIAGFKGHHWIRDSWNALNNNYLRPILVNKNNMKEMDKTKLVRKYKHLVDEDAKKIARGDLNSNMVFTKALIEHTRSRTNTMIDGVSSTSKIDFTKHMKENFGVTVYDDHSTVPMTPTHLFQETTEVEYSVRSEINDNDGFENDGYESDESGSFHERV
Protein: Putative glutamine amidotransferase YLR126C (EC 2.4.2.-) (Q12288)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May have a role in copper and iron homeostasis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Putative uncharacterized protein YLR124W
- Glutamyl-tRNA
- Glutamine synthetase
- Dihydroorotate dehydrogenase
- 1-
- Protein MAM3
- Uncharacterized protein YPL034W
- Aspartate--tRNA ligase, mitochondrial
- Glutamate synthase
- Protein transport protein GOT1
Sequence:
MTVKKIAILYTDEDNEWSKPWGNFVDMAIKLLEQTRKLECIAEDVEYEVFHVQKNVFPQLSDLQKDEYLGIYITGSKYDSFDNEIEWIMKLRSFLNEMLTSKTEYPPVAGICFGHQVIAAALGSSVGRNPKGFEGGVVSLKLNSVGQKLFGAQELNLSEVHSDCVFDVPEGYQNWASSEKCQNQGFYRQNRVLTFQGHPEFNSDVAQKGLLKSQDKLTLEEFNRYERQCQELDNNGIQAARNIWRLFLQKI
Protein: Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1) (Q8R1K1)
Organism: Mus musculus (Mouse)
Function: Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8NBM4}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- FAS-associated factor 2
- Nuclear protein localization protein 4 homolog
- Ubiquitin recognition factor in ER-associated degradation protein 1
- UBX domain-containing protein 8
- E3 ubiquitin-protein ligase AMFR
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 1
- FAS-associated factor 1
Sequence:
MFTSTGSSGLYKAPLSKSLLLVPSALSLLLTLLLPHCQKFFVYDLHAVKHDLQIWRLICGRIICLDLKDAFCSGLLIYNFRIFERRYGSRKFASFLLGSWVLSALFDFILVEAVQYSLGVTVASNLPSGFLAPVFALFVPFHCSIPRVQVAQILGPLSITNKTLIYILGLQLFTSGSYIWIVAMSGLISGMCYDRKVLQVHQVLRIPGRMAEFFSWALEPIFSSSEPTSEARVGMGATVDIQRQQRMEQLDRQLMLSQFAQVRRQRQQQGGMINWNRLFPPLRQRRNINYQDGPRSEQRASPPLEVSEEQVARLMEMGFSRGDALEALRASNNDLNVATNFLLQH
Protein: Suppressor protein of bem1/bed5 double mutants (EC 3.6.4.6) (Q09803)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Involved in multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex (By similarity). Plays a role in regulating nuclear envelope (NE) morphology and nuclear integrity, particularly during spindle pole body (SPB) extrusion or insertion through the NE, and perhaps during karyokinesis.
Subcellular location: Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting-associated protein vts1
- Vacuolar protein-sorting-associated protein 46
- Vacuolar-sorting protein snf7
- Vacuolar protein sorting-associated protein 20
- ESCRT-III complex subunit did4
- Vacuolar protein sorting-associated protein ist1
- Uncharacterized protein C162.06c
- Vacuolar protein sorting-associated protein 24
- Vacuolar protein-sorting protein bro1
- Vacuolar protein sorting-associated protein 27
Sequence:
MSNPDCLSKAISLVKTAIDNDNAEQYPDAYKYYQSALDYFMMALKYEKNEKSKEIIRSKVIEYLDRAEKLKVYLQEKNNQISSKSRVSNGNVEGSNSPTANEALDSDAKKLRSALTSAILVEKPNVRWDDIAGLENAKEALKETVLLPIKLPQLFSHGRKPWSGILLYGPPGTGKSYLAKAVATEAGSTFFSISSSDLVSKWMGESERLVRQLFEMAREQKPSIIFIDEIDSLCGSRSEGESESSRRIKTEFLVQMNGVGKDESGVLVLGATNIPWTLDSAIRRRFEKRIYIPLPNAHARARMFELNVGKIPSELTSQDFKELAKMTDGYSGSDISIVVRDAIMEPVRRIHTATHFKEVYDNKSNRTLVTPCSPGDPDAFESSWLEVNPEDIMEPKLTVRDFYSAVRKVKPTLNAGDIEKHTQFTKDFGAEG
Protein: Cyclin-dependent kinase 2 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 cognate) (P23573)
Organism: Drosophila melanogaster (Fruit fly)
Function: Like Cdk1, could play a key role in the control of the eukaryotic cell cycle.
Interaction partners:
- G1/S-specific cyclin-E
- G2/mitotic-specific cyclin-A
- Dacapo
- Cyclin D, isoform D
- Cell division control protein
- Wee1-like protein kinase
- S-phase kinase-associated protein 2
- Transcription factor E2f1
- CDC45L
- Double parked, isoform A
Sequence:
MTTILDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNMPQPITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVDHVALPVDPNAGSASRLTRLV
Protein: Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2) (P80202)
Organism: Rattus norvegicus (Rat)
Function: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2 (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Activin receptor type-2B
- Growth/differentiation factor 8
- Activin receptor type-2A
- Inhibin beta A chain
- Growth/differentiation factor 11
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 3
- Activin receptor type-1C
- Inhibin beta B chain
- Activin receptor type-1
Sequence:
MAESAGASSFFPLVVLLLAGSGGSGPRGIQALLCACTSCLQTNYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYIDFCNKIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
Protein: REST corepressor 3 (Q9P2K3)
Organism: Homo sapiens (Human)
Function: May act as a component of a corepressor complex that represses transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Interaction partners:
- Lysine-specific histone demethylase 1A FAD-dependent demethylase 1A)
- High mobility group protein 20A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
- Histone deacetylase 2
- Genetic suppressor element 1
- Histone deacetylase 1
- Zinc finger protein SNAI1
- PHD finger protein 21B
- REST corepressor 1
- C-terminal-binding protein 1
Sequence:
MRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEVLQEWEAEQGTQASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPPSLIGIQTDSQSSLH
Protein: Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h) (P23881)
Organism: Mus musculus (Mouse)
Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Transcription elongation factor SPT5
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB4
- Transcription elongation factor SPT4-A
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
Sequence:
MGLEEELLRIAKKLEKMVSRKKTEGALDLLKKLNSCQMSIQLLQTTRIGVAVNGVRKHCSDKEVVSLAKVLIKNWKRLLDSPRTTKGEREEREKAKKEKGLGCSDWKPEAGLSPPRKKGGGEPKTRRDSVDSRSSTTSSPKRPSLERSNSSKSKVETPTTPSSPSTPTFAPAVCLLAPCYLTGDSVRDKCVEMLSAALKAEDNFKDYGVNCDKLASEIEDHIYQELKSTDMKYRNRVRSRISNLKDPRNPGLRRNVLSGAISPELIAKMTAEEMASDELRELRNAMTQEAIREHQMAKTGGTTTDLLRCSKCKKKNCTYNQVQTRSADEPMTTFVLCNECGNRWKFC
Protein: Prohibitin (A8K401)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU366048}.
Interaction partners:
Sequence:
MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ
Protein: DnaJ heat shock protein family (Hsp40) member A3 (A0A0G2K5E4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Stress-70 protein, mitochondrial
- Endoplasmic reticulum chaperone BiP
- Mitochondrial disaggregase
- Heat shock 70 kDa protein 1A
- GrpE protein homolog
- Heat shock cognate 71 kDa protein
- Heat shock cognate 71 kDa protein
- Mitochondrial import inner membrane translocase subunit TIM44
- Heat shock 70 kDa protein 4
- GrpE protein homolog 1, mitochondrial
Sequence:
MAARCSPRWFRVAVGTPRLPAAAGRGVQQPQGGVVAASLCRKLCVSAFGLSMGAHGPRALLTLRPGVRLTGTKSFPFVCTASFHTSASLAKDDYYQILGVPRNASQKDIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASSSGQGYWRGGPSVDPEELFRKIFGEFSSSPFGDFQNVFDQPQEYIMELTFNQAAKGVNKEFTVNIMDTCERCDGKGNEPGTKVQHCHYCSGSGMETINTGPFVMRSTCRRCGGRGSIITNPCVVCRGAGQAKQKKRVTVPVPAGVEDGQTVRMPVGKREIFVTFRVQKSPVFRRDGADIHSDLFISIAQAILGGTAKAQGLYETINVTIPAGIQTDQKIRLTGKGIPRINSYGYGDHYIHIKIRVPKRLSSRQQNLILSYAEDETDVEGTVNGVTHTSTGGRTMDSSTGSKDRREAGEDNEGFLSKLKKIFTS
Protein: DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) (P33993)
Organism: Homo sapiens (Human)
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
Subcellular location: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}.
Interaction partners:
- DNA replication licensing factor MCM2
- TIMELESS-interacting protein
- DNA replication licensing factor MCM6
- DNA replication factor Cdt1
- DNA replication complex GINS protein PSF3
- Cell division control protein 45 homolog
- Origin recognition complex subunit 6
- DNA replication complex GINS protein PSF2
- Cell division control protein 6 homolog
- DNA replication licensing factor MCM3
Sequence:
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
Protein: Serine/threonine-protein phosphatase PP-Y (EC 3.1.3.16) (P11612)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- LD24014p
- FI19335p1
- WD repeat-containing protein 82
- Cleavage and polyadenylation specificity factor 73
- Cleavage and polyadenylation specificity factor subunit 1
- Probable cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 4
- Factor interacting with poly
- non-specific serine/threonine protein kinase
Sequence:
MAVLTTHEIDCIIKELTSLNGSECTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPCHKYKMIATDANQMPTNEEE
Protein: Germin-like protein subfamily 3 member 1 (At-GERM1) (AtGER1) (AtGLP1) (P94040)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000250}.
Interaction partners:
Sequence:
MLRTIFLLSLLFALSNASVQDFCVANLKRAETPAGYPCIRPIHVKATDFVFSGLGTPGNTTNIINAAVTPAFAAQFPGLNGLGLSTARLDLAPKGVIPMHTHPGASEVLFVLTGSITAGFVSSANAVYVQTLKPGQVMVFPQGLLHFQINAGKSSASAVVTFNSANPGLQILDFALFANSLPTELVVGTTFLDATTVKKLKGVLGGTG
Protein: Cell division control protein 6 homolog (CDC6-related protein) (p62(cdc6)) (O89033)
Organism: Mus musculus (Mouse)
Function: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q99741}. Cytoplasm {ECO:0000250|UniProtKB:Q99741}. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells. {ECO:0000250|UniProtKB:Q99741}.
Interaction partners:
- DNA replication licensing factor MCM7
- Cyclin-A2
- Origin recognition complex subunit 1
- DNA replication licensing factor MCM2
- DNA replication factor Cdt1
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM5
- Origin recognition complex subunit 2
- DNA replication licensing factor MCM3
Sequence:
MPQTRSQTQATIGFPKKKLSNTLKKPNSRDCEVKLRNVQPVPTTPCVDVKLLPLSPRKRLGDDNLCNTPRLSPCSPPKLGKKENGPPRSHTWKGCRLVFDDEPTFKASPPKEQDRVRQHQIRSSSAQRSPESKADPEQKCPPEKESVCIRLFKQEGTCYQQAKLVLNTAVPDRLPAREQEMGVIRNFLKEHICGKKAGSLYLSGAPGTGKTACLSRILQDFKKEVKGFKSILLNCMSLRSAQAVFPAIAQEIGREELCRPAGKDLMRKLEKHLTAEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLEARENCKPQLLNFPPYTRNQIAAILQDRLSQVSKDQVLDSAAIQFCARKVSAVSGDIRKALDVCRRAIEIVESDVRSQTVLKPLSECKSPSESPVPKRVGLAHISQVISEVDGNRVTLSQENTQDSLPLQQKILVCSLLLLTRRLKIKEVTLGKLYEAYSSICRKQQVTAVDQSECLSLSGLLESRGLVGLKKNKESRLTKVSLKIEEKEIEHVLNGKAFTGNILAAGLP
Protein: At4g39040 (RNA-binding CRS1 / YhbY (CRM) domain protein) (Q9SVI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- U11/U12 small nuclear ribonucleoprotein 31 kDa protein
- DEAD-box ATP-dependent RNA helicase 3, chloroplastic
- CRM-domain containing factor CFM2, chloroplastic
- CRM-domain containing factor CFM3B, chloroplastic
- Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic
- Protein REGULATOR OF FATTY ACID COMPOSITION 3
- CRM-domain containing factor CFM9, mitochondrial
- CRM-domain containing factor CFM3A, chloroplastic/mitochondrial
- Putative pentatricopeptide repeat-containing protein At3g16890, mitochondrial
Sequence:
MERVTASASCSSTHLIHNLLRHPKPPSPVCLFLRPFCFSASVSQSNHRNKPRFQSFSSKPLPCHSASLVVKSFSSIDEPDLEEDEESEDEDFSAEEYEYEDEEEEDEQDSGVVVSERGIEDSEASEEVSEIGDKEEKTENTKKKKSRGSALKLSIKEKKELASYAHSLGDKLKCQLVGKSGVTDSVVFSFLETLEKNELLKVKIRKTSPDELEDAVQHLEEATGSVAVGQIGRTVILYRPSPTKMKAEAKKKEVERMSITRRQKYANTRPTKPFRREYSERPDGRGRRGGSRVPTA
Protein: Scavenger receptor class B member 1 (SR-BI) (F5H5E8)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane, caveola {ECO:0000256|ARBA:ARBA00004189}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004189}.
Interaction partners:
Sequence:
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLVRLP
Protein: Probable carboxylesterase 6 (AtCXE6) (EC 3.1.1.1) (Q9SX25)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carboxylesterase acting on esters with varying acyl chain length.
Interaction partners:
- Protease inhibitor/seed storage/lipid transfer protein
- ACD11 homolog protein
- Protein PELPK1
- Cysteine-rich repeat secretory protein 55
Sequence:
MGGTKLTHVTTTNPNNSNIHGPVVDEVEGLIKVYKDGHVERSQLLPCVDPSLPLELGVTCSDVVIDKLTNVWARLYVPMTTTKSSVSKLPLIVYFHGGGFCVGSASWLCYHEFLARLSARSRCLVMSVNYRLAPENPLPAAYEDGVNAILWLNKARNDNLWAKQCDFGRIFLAGDSAGGNIAQQVAARLASPEDLALKIEGTILIQPFYSGEERTESERRVGNDKTAVLTLASSDAWWRMSLPRGANREHPYCKPVKMIIKSSTVTRTLVCVAEMDLLMDSNMEMCDGNEDVIKRVLHKGVGHAFHILGKSQLAHTTTLEMLCQIDAFIHHYDPLN
Protein: Transmembrane protein 185A (Erythropoietin-induced EST 3) (Protein FAM11A) (A2AF53)
Organism: Mus musculus (Mouse)
Subcellular location: Cell projection, dendrite {ECO:0000269|PubMed:15525354}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD
Protein: Uncharacterized N-acetyltransferase C1271.07c (EC 2.3.1.-) (O94340)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Carbonic anhydrase
- N-alpha-acetyltransferase 35, NatC auxiliary subunit
- Small nuclear ribonucleoprotein E
Sequence:
MMKPSNISISAVKLPQDLDDFKMLVQEYLQEFGMDLTFQNVDDELANPMRKYGPPHGIMLVARDEHGTALGCVAVHPFGGPGCCEMKRLYVRPESRGLKLGVLLVKEIIQYSEKLGYSSMVLDTLDTLLPAVRLYKSFGFKTTEPYYHNPIPNVVYMRLEMSK
Protein: Immune-associated nucleotide-binding protein 8 (AtIAN8) (Protein AIG1) (P54120)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Retroelement pol polyprotein-like family protein)
- Germin-like protein subfamily 1 member 4
- Lectin-like protein
- Probable flavin-containing monooxygenase 1
- Nudix hydrolase 6
- Protein AIG2 A
Sequence:
MANDQKNSESFPAKEDHKKDDAAAPAEVDHKDEFSASQPHPVENIVLVGRTGNGKSATGNSIVRSKVFKSKTKSSGVTMECHAVKAVTPEGPILNVIDTPGLFDLSVSAEFIGKEIVKCLTLADGGLHAVLLVLSVRTRISQEEEMVLSTLQVLFGSKIVDYLIVVFTGGDVLEDDGMTLEDYLGDNMPDFLKRVLILCGQRMILFDNKTKDDEKKTKQVHELLKLIDLVRKQNNNIPYTDEMYHMIKEENERHKKEQEELESKGHSEEQLAALMKELQIMNERNLKAMAEMMEKNMKIAMEAQEKLFEQREKAQEMSYQQKMEMQEKLKQMEGRMRAEMEAQMLSRQQCSIL
Protein: anthranilate synthase (EC 4.1.3.27) (F4K0T5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSSSMNVATMQALTFSRRLLPSVASRYLSSSSVTVTGYSGRSSAYAPSFRSIKCVSVSPEASIVSDTKKLADASKSTNLIPIYRCIFSDQLTPVLAYRCLVKEDDREAPSFLFESVEPGSQMSSVGRYSVVGAQPAMEIVAKENKVIVMDHNNETMTEEFVEDPMEIPRKISEKWNPDPQLVQDLPDAFCGGWVGFFSYDTVRYVEKRKLPFSKAPEDDRNLPDMHLGLYDDVVVFDHVEKKAYVIHWIRLDGSLPYEKAYSNGMQHLENLVAKLHDIEPPKLAAGNVNLQTRQFGPSLDNSNVTCEEYKEAVVKAKEHILAGDIFQIVLSQRFERRTFADPFEVYRALRVVNPSPYMGYLQVGDGENISQQLCILYLWINHQCCFRSVIQARGCILVASSPEILTKVKQNKIVNRPLAGTSKRGKNEVEDKRLEKELLENEKQCAEHIMLVDLGRNDVGKVTKYGSVKVEKLMNIERYSHVMHISSTVTGELQDGLTCWDVLRAALPVGTVSGAPKVKAMELIDELEPTRRGPYSGGFGGVSFTGDMDIALSLRTIVFPTACQYNTMYSYKDANKRREWVAYLQAGAGVVADSDPQDEHCECQNKAAGLARAIDLAESAFVKK