wanglab/gogpt-training-data huggingface dataset:
Protein: 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) (B2KTE2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAADDKASSSSSVMDWSSEPPPSPTSPSHLTHFKPLTPEQDEPPLRSAYSSFVSLFRFNKEEGRPPSVTEKSQSASSSPQGPRRNWSSPSHSIHGSETHRKHPELLRRTSAASEGRRKSEAPLGSHDPRTAVQLRTALKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCNEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSSSIGEDLSALSDSPCSVCVLEPTEPRTPVGGRKASRNIFLEEDLAWQRKNSIGMRKNHQESQNSGLNSRLTVVQEDIGKSPARKRSASVTNLSLDRSGSSMVPAYESSVSPQNSRALPKTDHSEEERKILLDSFQLKDIWKKICHNTTGMEFQDHRYWLRTYPNCIVGKELVNWLLRNGTISTRAQAIAIGQALVDGRWLDCVTHHDQIFRDEYALYRPLQSTEFSETPSPDSDSVNSLEGHSEPSWFKDIKFDDSDTEQLADENDYVTPSSSSPSKRTSVSSFHSAVDSDSAASISLNMEQDNVNFHIKKQAKYPHVPPYPAEQKMEVLLSEDGGQHISISDAFIKESLFNRRVEEKAKEMLFTPLGWHHSSLDQLREENGEKKAMERLLSANHSHMMALLQQLLYSESLSLSWRDIIVPVVRQVVQTVRPDVRSCDDDMDIRQFVHIKKIPGGKKFDSAVVNGFVCTKNIAHKKMNSYIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPNLVLVEKTVSRIAQDMLLEHGIAIVINVKPQVLDRVSRMTQGDLVISMDQLLTKPRLGTCHKFYLHSFQLPNSEVKTLMFFEGCPPQLGCTIKLRGASEYELARVKEIIIFMVCVAYHSQLEISFLMDEFAMPPSLAESSSFPCLLESTTLREEDETSGERESQDNDESTLGDDNLTLVPGDDFETGFTGTIKAHSREPSTSESSHKDGESPRINKNASITSFSGGEEENIKTSTPLSSFSSTFPQPVTPPFLISDVKEMSQEVVKGSGEGEKNKYLESTLVHQDSTSSETSLPPTRLFRDPLQDDTGLFVTEHVASSDDRLKSISALFKQELKDIILCISPFITFREPFLLTPAGLRCPSRDYFPEQVYLSPLLNKDSKELDGRRKRQLLKESSPGSGSLTNGSVSHQRAIQILPCHKLTSARIAEQVGSSQQLARMLADYRAQGGRIRQREGTQFREAPPPKAPIKADSEEDKGAGVIDMTWSTKLDCLNPINHQRLCVLFSSSSAQSNNAPNPCVSPWIVTMEFYGKNDLTLGVFLERYCFRPSYQCPSMYCETPMVHHIRRFVHGKGCVQIVLKELDSPVPGYQHTILNYSWCRICKQVTPVVPLSNDSWSMSFAKYLELRFYGHQYTRRANAEPCGHSIHKDYHQYFSYNQMVASFSYIPVRLLEICLPPPKIIIRNQGPSKSSLQQDLKDFSQKVAQVYLAIDDRLTSLKTDTFSKTREEKMEDMFAQKDMEESELRGWIEKLQVRLQTSVIDSSQQLQAVLESVVVKKQGLCETLQSWNNRLQELFQQEKGRKRLSVPPSPGRHRQPTTDESKTSALESSPRNPSPVVPNGDKEDRHLNTFPSSSGSSSLLQLPSPAEQPSDVITSGPSFPDQDSVSNPEDMFDGHLLGSNDSQVKEKSTMKTILANLLPGNSYNPIPFPFDPDKHYLMYEHERVPIAVCEREPSSIIAFALSCKEYKTALEELTKTTAKTGGDDTSQTISAGESRVKNSPAKPSDNSMSQLSRSSVDADPLKEPESADKQKKQTGNPHIELQFSDANAKFYCRIYYAEEFHKMREEIMESTEDDFVRSLSHCVNWQARGGKSGAVFYATEDDRFILKQMPRLEVQSFLDFAPHYFTYITGAVHLKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNRNVKTDQGKESCEVVLLDENLLKLVHDNPLYIRSHCKAILRAAIHSDALFLSSHLIIDYSLLVGRDDSTDELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPDHWSGLGLNC
Protein: E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) (Syntaxin-1-interacting RING finger protein) (Protein staring) (Q8CJB9)
Organism: Rattus norvegicus (Rat)
Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O75150}.
Interaction partners:
- E3 ubiquitin protein ligase
- Ubiquitin-conjugating enzyme E2 B
- WW domain-containing adapter protein with coiled-coil
- RNA polymerase II-associated factor 1 homolog
- E2 ubiquitin-conjugating enzyme
- Parafibromin
- RNA polymerase-associated protein CTR9 homolog
- Tuftelin-interacting protein 11
- Ubiquitin conjugating enzyme E2 U
- Ubiquitin-conjugating enzyme E2 N
Sequence:
MSGLSNKRAAGDGGSGPPEKKLNREEKTTTTLIEPIRLGGISSTEEMDSKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLQCYENQRELSSSGTEVPGCQEGLTRDVIPRTDPGTSDLREPLPMQFRAPLSEPALAFVVALGASSCEEVELQLQGRMEFSKAAVSRVVEASDRLQRQVEELCQRVYSRGDSEAPGEVARARTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSTETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSTGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLASKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSSHCGPNLSHPDDSGLNALAPGKEDSGPGPGGTPDSKKELALVAGATSVASSVKKEELVSSEDDAQALAPGTQGLPSRGREPEARPKRELREREGPSLGPPPAASTLSRADREKAKAEEARRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRDLEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRVYIS
Protein: SNF2 DNA repair protein, putative (Q384V0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proliferating cell nuclear antigen
Sequence:
MEQLLRRGQEYCFDCCSQRLFRISRFGCVFECRCPDGILNVQSVLRDYVAELNEGERFIEFVPVISGRISTHNCKIAQVEIDFTNRCVRLGFMNMTTSASLQIMKELPLSLSESTMIQEGCFRYSIDSLDLLLHELRMLSGESGNRLHVNEPSRVCREAISTVKENKAVHLPDLLPPKLMAALHRHQVDGICKALSFGGRAMFADEMGVGKTLQAIGTLAALNAFPALIVCPAALRHMWADELEKWLMDVLNMDDIRVITSSSDFLSRSDEPKVVVTSFHMVSLLANHMKSRQWSSLVVDESHILHTSVDASCDAHYTTLLCELGRRTKYCLLLTGTPSLSTPFDLFNQVDTVCPGLLGSSRFEFALRYCRIEFSPYFRTFECTRSTELHSLLNATCMIRRLKSETLVDLPTKQRVILRIPTDAIRGQKNKSLFQKVYSDNWIESREKILDIVDLLLCKHGKIVLFAHHLNLLDCLTTYVNDKKVTWIRIDGGTPMNSRVELLSRFNDGDVSVALVGITACAVGVRLTGASCALFAELPPDIGWMQQAEDRLHRPGQKNHVILYYIISTGSFFDGAQFSRLSRSFQAVRRITDGVKLSLDASYLSGTAPVHNALLEEEATPSAGHPAPSFLDISGLSAPLLFRISHNTGRIHVVHEGKHLTSLSTQEAQQYWRHDGEFPRQLRDYLSHVDMLSPVERRRLRTAAAWLPSNFTWRPVRAPRKTVVRYAKSDILLGRVFFWKVVKRNFPERTYGALLVPLETHFLPVCLECDSTLVASEFISPGSVVRIDDDTRMFCSGACRGVFFIKRSSSAARRGVQEVDKGICSVCQVDCELLYSLAVAATSRSEREDILDRLHPQLRQHPVLFNRIVEHPTPGSIWNADHILAVSQGGGSSDLDNLQTLCVACHADKTVSEARVGYKAVAEKVPRTTVNLASLHFLSRGVRRVTSACPTV
Protein: Zinc finger protein, FOG family member 2 (E7ET52)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYSKGGQLWCTTTKAISEGEELIAFVVDFDSRLQAASQMTLTEGMYPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNLQAHLMYYCSGRQREAAPVSEENEDSAHQISSLCPFPQCTKSFSNARALEMHLNSHSGVKMEEFLPPGASLKCTVCSYTADSVINFHQHLFSHLTQAAFRCNHCHFGFQTQRELLQHQELHVPSGKLPRESDMEHSPSATEDSLQPATDLLTRSELPQSQKAMQTKDASSDTELDKCEKKTQLFLTNQRPEIQPTTNKQSFSYTKIKSEPSSPRLASSPVQPNIGPSFPVGPFLSQFSFPQDITMVPQASEILAKMSELVHRRLRHGSSSYPPVIYSPLMPKGATCFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKMPEALSPNTGQTSINLLNPAAHSADPENPLLQTSCINSSTVLDLIGPNGKGHDKDFSTQTKKLSTSSNNDDKINGKPVDVKNPSVPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYCATRHDPPLKRSASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVANLNNPCTSTQEPTEGLGECYHPRCDIFPGIVSKHLETSLTINKCVPVSKCDTTHSSVSCLEMDVPIDLSKKCLSQSERTTTSPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPESERNSPDVSYERSIIKCEKNGNLKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENRHLFLPQCLYPGAIKKAKGADQLSPYYGIKPSDYISGSLVIHNTDIEQSRNAENESPKGQASSNGCAALKKDSLPLLPKNRGMVIVNGGLKQDERPAANPQQENISQNPQHEDDHKSPSWISENPLAANENVSPGIPSAEEQLSSIAKGVNGSSQAPTSGKYCRLCDIQFNNLSNFITHKKFYCSSHAAEHVK
Protein: Alpha-(1,3)-fucosyltransferase fut-6 (EC 2.4.1.-) (G5EEE1)
Organism: Caenorhabditis elegans
Function: Involved in the fucosylation of N-glycans. Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the distal GlcNAc residue in N-glycans. Catalyzes the transfer of fucose to Gal-beta-1-4-GlcNAc-alpha-pNP (LN-pNP) and Gal-beta-1-4-GlcNAc-beta-1-3-Gal-beta-1-4-Glc (LNnT). Unlike alpha-(1,3)-fucosyltransferase fut-1, does not transfer fucose to Man-alpha-1-3-(Man-alpha-1-6)-Man-beta-1-4-GlcNAc-beta-1-4-GlcNAc-beta-1-Asn (M3), Man-alpha-1-3-(Man-alpha-1-6)-Man-beta-1-4-GlcNAc-beta-1-4-(Fuc-alpha-1-6)-GlcNAc-beta-1-Asn (M3F6) and GlcNAc-beta-1-2-Man-alpha-1-3-(GlcNAc-beta-1-2-Man-alpha-1-6)-Man-beta-1-4-GlcNAc-beta-1-4(Fuc-alpha-1-6)-GlcNAc-beta-1-Asn (GnM3F6).
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000255|RuleBase:RU003832}; Single-pass type II membrane protein {ECO:0000255|RuleBase:RU003832}.
Interaction partners:
- Alpha-
- beta-N-acetylhexosaminidase
- beta-N-acetylhexosaminidase
- Beta-1,4-galactosyltransferase galt-1
- Alpha-galactosidase
- GDP-L-fucose synthase
- beta-N-acetylhexosaminidase
- GDP-mannose 4,6 dehydratase 1
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Sequence:
MSQIGGATCTWRYLGRFVTLGIYASVALFVWYTLVPTRSKHKDSIAINNNNADPATALIPVHTKNVVIYAATKFFGHPITTERFLATCPDVQNYCRITQEESEFDNADAVLFHNADYRGSTDKFKKMKSQRKPGVPYVLWSLESPTNDMFRPDSHMINWTMTYRTDSDVWAPYGTIVKLKNPVEVDLNAIWEGKTKTATWLASNCITQNHRFDLIKKIIDNGFEIDIWGNCGKQVSQCAGVDNQESPCVLELIKPYKFYISMENSNCKDYVTEKFWKALNDRMTIPIVLARKYYKDLGVPDSAYIAVDDYATLDEFLAHVKKVNKEKDLFLSYHQWRKEWKVIIGSGFSGWCTLCNKLQDKDYILKNPKSYKDVAWWHSFEMCNNQIASKYL
Protein: Uncharacterized protein (Q385P8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDKSKTMEILRSMKFMQRKEEAKRRELFEADQKRRMEERLRKPSAAGSGTSGAGDGSFVTPAINGPSADTGRKTATIFYDVNFPRELYSHSRLSFAAKALATASSSSVAGAGAEEAREFQQREKEEEDCGSRHGGGAEHSSDDGEYWEDINEKDATAVEFGNKKKRFCVKSNAPKLPKDLERKVSGVKRKRRGGRGE
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q66HY1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MKSTFTIIVFGVLVAAVLLSPLAEGGQNPDYMLHGTGVKPGSDPRRAQAGDGSTVAPEDAARFLSCYCSGHCPEDATNNTCETNGHCFAIIEEDEHGEAMLTSGCMKYEGSHFQCKDSPNAQTRRTIECCSTDFCNRDLQPTLPPPIPGKPPFWNAHLLAFLISVTVCCFTLVAITIVCYYRFKLQTGRRHYQRDLGPIEAFIPAGESLKDLISQSSTGSGSGLPLLVQRTIAKHIQMVRQIGKGRYGEVWLGRWRGENVAVKVFFTREEASWFRETEIYQTVLMRHENILGFIAADIKGTGTFTQLFLITDYHENGSLCDYLKYTTLDTQALLRLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGTCCIADLGLAVKYNSDTNEVDVPLSTRMGTRRYMAPEVLDETLNKNQFQAYIMADIYSYGLIVWEMARRCVTGGIVEEYQLPYWDMVPSEPSYEDMREVVCVKSMRPVVSNRWNSDECLRVMLKLMSECWAHNPASRLTALRVKKSLAKMVESQDIKI
Protein: Beclin-1-like protein A (Autophagy-related protein 6A) (Q55CC5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in autophagy. May be required to recruit the atg8-phosphatidylinositol conjugate and the atg12-atg5 conjugate to the pre-autophagosomal structure (By similarity). Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.
Subcellular location: Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Probable serine/threonine-protein kinase vps15
- Serine/threonine-protein kinase atg1
- Phosphatidylinositol 3-kinase VPS34-like
- Ubiquitin-like modifier-activating enzyme atg7
- Autophagy-related protein 9
- Autophagy protein 5
- Autophagy-related protein 18
- Autophagy-related protein 8
- Probable serine/threonine-protein kinase DDB_G0291918
- Ubiquitin-like protein atg12
Sequence:
MKKSDSSSSLVFSGIQIEINNNYGSGSGSNNNNNNNNNNNNINNNNNPNNNPNNNGPPLRPSSEWVLLSSSQPTIATTTNLTTNAPLSDSMIMNYVGNDNLNTPITPSTSSPYLKRNNSNLNSIIENSNNSSPSNAITRNNSFNMDPNNNNNNNNNNNNNNNNNNNNGEYMNSSIVFDNNVNNNNNNPNNNPNNNVHSNSHNTNNSITHSGSITSSNSNNNNSNNNNNNNSNNNNNINNSVNSVNSLMMNSDKNCNHQFPSDDVLISNEHDIIDLALNKEFLNQYRIQTNSIFINSQHVINQDVQSYQDYESLLSSYNTILNQLLLITSSNKNNNNNNNPNNNNNNVTSPNSLLSPPSTSQLQQQQQQQQQSPSPPLNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNYYLMSTSTMSSTTTNLSTSTNSNINTNIPTNYNMSTSITATTTTTTATNTIAIGTTTTAAITTAATNSTNSNNLNLSSTNLGLDNNFLYQRILPEILSLLEKLTVFSRNNDTEIFNRLGNNVKLIFDHLNLIKNDILEANFSHLSGIFTIYNHTIISSDKTTKQFVFRFLHSLAPMTVPPAIVVTPELKKVVQKIHFSKPTFTPLCIEWKEICKYIDVLKSVSLFIAQVGQYCFLNQSIIINDELLFIPSIYVLFDNIQNLSMKEERFHIEYILHNLKFIVSKIPKQTREFTKTEIERLYSYIRGNPSYVKEILPKLLKNIYIDPYFYHLWNNHCIHLLNNNINNNNNNNTNNSSNNSNNNNNTNINIGKDIGNDLTLLLVSNKNSFLLSFDERHFSIFYSSISNSTTTTITPTITSPNNNSNRINNNNNNNNNNNNNNNNNNNINVNNNVNNNNVNNNNNNNNNNSNQYIVNYFDNTTSLLNFIESNQFKYIILSNKEVETIKFFKSVLPVTLPLPQPSSRQAILQQQQQQNYKPRILCGPCLSRFKTILDEFDNEESIENQIYSNYLNNINNNENIDPNLIDGNENKINGNDNNNNHDDDEKTNNNNNNNNNNNNNNNNNIYNNNNIEDYNNNNDNNYNFENEINDKENEFRELEKEINEIEKEEQELIKEYLELENRNQINLDIKQKLEDILKEIKLEEKTHYDLVNNYYQEYFDLKQEDEIYTNQINAIRDQLERVSQIDINKITFKIELPNTGVNGGIVGYNESSNTTISSINGFRLGTLSNLKVDWEEINSAWGETSLLLYVLASQLEFNFQNYKLIPMSSKSIIQSKNDKMSYTLYGGDNIQFSRSFLWFGASDQRFDSGMEAFLSCVNDIATFVQSKKPSINFNYRISKDKIGDSNRLLSIKIAGNSELNWTMALRFMLSNLKKILDNLDSIVESKQKQQQLQRQQSLNNL
Protein: 26S proteasome regulatory subunit rpn1 (19S regulatory cap region of 26S protease subunit 2) (Proteasome non-ATPase subunit mts4) (P87048)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- Probable 26S proteasome subunit rpt4
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit rpn11
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit rpn8
- 26S proteasome regulatory subunit rpn7
- 26S proteasome regulatory subunit 4 homolog
- Probable 26S proteasome regulatory subunit rpn3
- 26S proteasome regulatory subunit rpn2
Sequence:
MSSKDISSKSPSGNDALNDKKGTKTSETNDRNSTNNTKERDELEDLSEEDLQLKNDLELLVQAVQDATPELVGSSLTQLKEIIRTSTSSMTAVPKPLKFLRPHYFTLVKIYDSWPQSPQKTQLADILSVLGMSYSNTSKHESLKYRLQGVTTDPSLWGHEYVRHLASEIEEEFASRQEEEAPTDDLMELALTIVPFFLTHNAEADAIDLLQELGAIEKVVPFVELDNASRVCLYITSCVNLLPFPEDVAMLRTAHAIYRKFDQLTQALNVAIRLDDMSLIKEDCEAATDPLLKKQMSYMLARQQIPMDMGDEELNDALNNTHLSDHFHYLGKELNLMDPKVPEDIFKTHLEVARTGLGASGVYSAKQNLANTFVNALVNAGYSNDRLILVDDEKTSWIYKNKESGLISATASIGLLQLWNVDMGLSLLDKYLYSSEENTKAGALLGIGVTNVAVRNEADPAMAILSEYLETGSVKLRASAILGLGLAYSGANREDLLDMLSPIVTDTDCPMQLSCLAALSLGLIFVGTCNGDVASTILQTLMEREESAQNDQWGRFMALGLALLFNGKQDLADATVETLKAIEGKIARQAEILVDICSYAGTGNVLHIQKLLHICSEPPSDDAKESETTIQTFAALGVATIAMGEDIGAEMVLRHFDHMMHYGEPSIRKAIPLALGLLSASNPQMRIFDTLSRYSHDNDLDVAYNAIFAMGLVGAGTSNARLAQLLRQLASYYHKESNALFMVRIAQGLLYLGKGTMTLNPYHTERQILGQTAFAGLMTVVLAMLDANTFVLDTSHWLLYAITLAIRPRMLITLGEDGQYLPVSVRVGQAVDVVGQAGRPKVITGWVTHTTPVLLHHNERAELATEAYTPLTSLEGIVILKKNTEDIEMTA
Protein: Crimpy, isoform C (Crimpy, isoform D) (MIP30551p) (A8JNW3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Protein 60A
Sequence:
MGGSARGVGRRGVVLEQDVRTRSSQGERKRGLAGKQQHNNAKLPLRMRSNGSYFGRLNVSALLIYLWCYLLLVMAASGGSNHVVNGLKCYCNPKECDVIRSPDCPGKGLMLWDPCKCCRICAKTLGESCGGPGGFSGQCEPPLQCVTKLPISSGLGVCMDLQHLTALTYSQHDNCSDSDSIVLEPGCEITNKRCQCWPTMRTCLSELTSDGGSPDDSRWHFKNLEDCQLNLQNLIKLEQEFDEDYKISPSKFTYKKLRRKRKSLKKRIIILKD
Protein: Calcium-dependent protein kinase 23 (EC 2.7.11.1) (Q9M101)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger. Could act as a calcium sensor involved in drought- and salt stress-induced calcium signaling cascades. Mediates the phosphorylation and activation of the S-type anion efflux channel SLAC1.
Subcellular location: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Guard cell S-type anion channel SLAC1
- Respiratory burst oxidase homolog protein F
- S-type anion channel SLAH3
- LRR receptor-like serine/threonine-protein kinase GHR1
- Respiratory burst oxidase homolog protein D
- Calcineurin B-like protein 1
- Aluminum-activated malate transporter 12
- Calcineurin B-like protein 9
- Protein phosphatase 2C 56
- S-type anion channel SLAH4
Sequence:
MGCFSSKHRKTQNDGGGERSIPIIPVQTHIVDQVPDHRKPQIPSPSIPISVRDPETILGKPFEDIRKFYSLGRELGRGGLGITYMCKEIGTGNIYACKSILKRKLISELGREDVKTEIQIMQHLSGQPNVVEIKGSYEDRHSVHLVMELCAGGELFDRIIAQGHYSERAAAGTIKSIVDVVQICHLNGVIHRDLKPENFLFSSKEENAMLKVTDFGLSAFIEEGKIYKDVVGSPYYVAPEVLRQSYGKEIDIWSAGVILYILLCGVPPFWADNEEGVFVEILKCKIDFVREPWPSISDSAKDLVEKMLTEDPKRRITAAQVLEHPWIKGGEAPEKPIDSTVLSRMKQFRAMNKLKKLALKVSAVSLSEEEIKGLKTLFANMDTNRSGTITYEQLQTGLSRLRSRLSETEVQQLVEASDVDGNGTIDYYEFISATMHRYKLHHDEHVHKAFQHLDKDKNGHITRDELESAMKEYGMGDEASIKEVISEVDTDNDGKINFEEFRAMMRCGTTQPKGKQYPFH
Protein: Heat shock protein 90 (Abnormal dauer formation protein 21) (Q18688)
Organism: Caenorhabditis elegans
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. In response to cellular stress, up-regulated in distal tissues in a pqm-1-dependent manner, preventing protein misfolding and maintaining proteostasis. By stabilizing the receptor-type guanylate cyclase daf-11 or another signal transduction component that regulates cGMP levels, plays a role in dauer formation and chemotaxis to non-volatile and volatile attractants detected by AWC sensory neurons. Participates in the control of cell cycle progression at the prophase/metaphase transition in oocyte development by ensuring the activity of wee-1.3 kinase, which negatively regulates cdk-1 through its phosphorylation. Regulates yap-1 nuclear export after heat shock treatment.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12950278}. Note=Perinuclear region of somatic cells.
Interaction partners:
- Probable Hsp90 co-chaperone cdc37
- Heat shock protein 70
- Stress-induced-phosphoprotein 1
- Co-chaperone protein daf-41
- Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein
- Serine/threonine-protein phosphatase 5
- UNC-45
- peptidylprolyl isomerase
- Heat shock protein hsp-1
- Heat shock transcription factor hsf-1
Sequence:
MSENAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASDALDKIRYQALTEPSELDTGKELFIKITPNKEEKTLTIMDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAFLVADKVVVTSKNNDDDSYQWESSAGGSFVVRPFNDPEVTRGTKIVMHIKEDQIDFLEERKIKEIVKKHSQFIGYPIKLVVEKEREKEVEDEEAVEAKDEEKKEGEVENVADDADKKKTKKIKEKYFEDEELNKTKPIWTRNPDDISNEEYAEFYKSLSNDWEDHLAVKHFSVEGQLEFRALLFVPQRAPFDLFENKKSKNSIKLYVRRVFIMENCEELMPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCMELIDEVAEDKDNFKKFYEQFGKNLKLGIHEDSTNRKKLSDFLRYSTSAGDEPTSLKEYVSRMKENQTQIYYITGESKDVVAASAFVERVKSRGFEVLYMCDPIDEYCVQQLKEYDGKKLVSVTKEGLELPETEEEKKKFEEDKVAYENLCKVIKDILEKKVEKVGVSNRLVSSPCCIVTSEYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHAIMKTLRDRVEVDKNDKTVKDLVVLLFETALLASGFSLEEPQSHASRIYRMIKLGLDIGDDEIEDSAVPSSCTAEAKIEGAEEDASRMEEVD
Protein: Prolactin-induced protein (E9PX96)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MYANPYSMASLQKFYQPGAVIYLLIVFLLQETAGFWYHGLHNEPRNYTLTLNMKITPSTSITNKKGNEFRVQLTVKNNVKQCQEVEINTEHERYIKFLSGPSTFETCICTISDFFWDIYVSESTYLTLSASILPYKNKCPDSDEPLLYGDSYQMYNITDKINVTP
Protein: Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] (Q9VT65)
Organism: Drosophila melanogaster (Fruit fly)
Function: Calcium-regulated non-lysosomal thiol-protease.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14614768}. Membrane {ECO:0000269|PubMed:14614768}. Note=Translocates to intracellular membranes when calcium levels are increased.
Interaction partners:
Sequence:
MYGIDNYPKNYHASGIGLVNLAALGYSKNEVSGGNEGGGAPKPKAGLYPSLPYPSSESVGGMPYVVKQTSHAQNASYAGPTMGMGMPVPEAPSAPAPYPSATPYPGSGLYPSLPSANVSSLPYPTAPMAPYPTGMPYPTGMPQPNLPYPAAPLAPYPSAMPGLPGMPMPYAPMPTSPAPQHNIGFPALPYPTAPPPESAPTQEEEPSVGVAELSFTSVKVPENQNMFWMGRKATSARQNSVSKGDFQSLRDSCLANGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKAAERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSMRDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLDDWLERTIYS
Protein: Submandibular gland protein C (A0A8I6AQ67)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKLILLYLAVVLCTVCKADRPNAYSGNSFSGELERIFDSNPTKASVSGDSNKVSGPSSSAVVSTDSGDDGNLEDKQVPRFNGDERDGENNSDFFGAGSLDTGNTSDSGSHNLSSGSGSSVRSNVSIGAGPSDQNESADLGGSGRVTCAGKTVSGASSVA
Protein: Transducin-like 2 isoform 3 (A0A0S2Z5C1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MELSQMSELMGLSVLLGLLALMATAAVARGWLRAGEERSGRPACQKANGFPPDKSSGSKKQKQYQRIRKEKPQQHNFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRCEGLGSLLWKEGGVPGGGASLRTKGPLRGCALVCFLQRLTEDGFCLQGWYMETVGHRCGIQEEAGPLLAEDRPL
Protein: Translationally controlled tumor protein 2 (AtTCTP2) (Q9M9V9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates proliferation. Induces whole plant regeneration when expressed in heterologous systems. Involved in root growth and lateral root development, with a probable role in cell reprogramming. The long-distance transport of TCTP RNA and/or protein in plants may have an important role in regulation of growth and development (Probable).
Subcellular location: Nucleus {ECO:0000269|PubMed:25566280, ECO:0000269|PubMed:26191065, ECO:0000269|PubMed:26237533}. Cytoplasm {ECO:0000269|PubMed:25566280}.
Interaction partners:
- Probable elongation factor 1-gamma 2
- Large ribosomal subunit protein uL18y
- Elongation factor 1-delta 1
- Elongation factor 1-beta 2
- Elongation factor 1-delta 2
- Elongation factor 1-beta 1
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Polypyrimidine tract-binding protein homolog 3
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS6z
Sequence:
MLVYQDILTGDELLSDSFPYKEIENGMLWEVEGKNPSGEEGGEDEGVDDQAVKVVDIIDTFRLQEQPSFDKKQFVMFMKRYIKQLSPKLDSENQELFKKHIESATKFLMSKLKDFQFFVGESMEGEEGSLVFAYYREGATDPTFLYLAYGLKEIKC
Protein: Actin domain-containing protein (Q54PQ2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Actin-interacting protein 1
- Profilin-3
- Profilin-1
- Alpha-actinin A
- Protovillin
- Actin-related protein 2/3 complex subunit 1
Sequence:
MTGFSIPNMSMLLKLANSRLVLHKNKNFEQSNVHKKEIAELLQLGKEEQARVRTVSVINEDYHTEVLGILIIYCETLANRIRGIEGVKVCPPDLKEACCSIIFASPYLDKQVELYKIRKRLIEKFGKKFPEECIDCCCINPKIVHRLSNKPPEESLVNYYLSNIAKKHNVAWDTPALPPLVDLQQSIPDFTLTSLAEQFPSAPSNGSGGGGNDDLLMDFPSVPKESTATIDQFPSPPTSNISTTSTTTTTTKLEFPNINNIPSIGIAEASQCKVSGDGLKKGIVGRECSFIIQAYDAKGNKHTKGGETFNVLIQGQYGDQLYGKVVDQQNGTYNVTYTPPKAGGYAIAIYLQNTPIGDQQPHISNIDEAPTISVGALDLVDPLKCEAYGPGLETGSPGVLSTFTIVARTSKGNPIEAGKLPPGQRFYVFVQGPPGIQIHGDIKNNNDGTFTATYTPTVAGGYGVMVYYENQPIRSEAWTFFILEKEKAPPKFPSIINVPLQQQVASTESEEDEMDKLWKQTSDLSFNPPVKSTAVIENYADAKAANIPEPPSFAKYQESIKAKSSRAEFFQKITEKTLVIDNGSGMVKAGFAGEDAPRCVFPSIIGYPMFNSVMHGMGKDKYIGDEAQAKRGILNIKYPIEHGIITNWNDMEALWEYTFTNELRVDASKHPVLLTEPPLNPKANRERMVETMFEYFNTPAVYIAIQAVLSLYASGRTTGTVLDCGDGVCHTVPIYEGYSIPHAIKRIDIGGRDITEYLMRLLTERGYAFTTTAEREIVRDIKEKTSFVSQDFYASMNAPEDNNILKDYTMPDKQVLTIGKERFRCYEAFFDPSVLGKDQNGIHHLLNETITSCDIDIRRDLYKNIVVSGGSTMATGFEKRLQKEMELLVSNPQVQIKINAPPNRDISVWCGGSVLGDLKTFSDQWITKQEYDEVGRGIVHRKCF