wanglab/gogpt-training-data huggingface dataset:
Protein: Insulin (I3WAC9)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU000406}.
Interaction partners:
Sequence:
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
Protein: Motor neuron and pancreas homeobox 2b (A2CEW5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MEKSKNFRIDALLAEEPHRGSREVSPGLSSDSPTGSPVSCRRGDTPSPRGTPGAIHLQPGIIPKPGLLNLPHPGLTSIPGMYTTPMYPISALGGQHPALAYTGFTQLTQPYPEQLKAAAMAGSLPLEHWIRAGIMVPRLPDYTSAPQSGLMGKCRRPRTAFTSQQLLELENQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSRKAKEQAAQVEVERQRGGTKPSGRDSRRAPAAPSVEEQEEEEEEEEEIDEDEEDEEDGQHKFINNSLSVSRSTDFLHHTAALYHPDSPFSEDDIEELHGGERKIRAGL
Protein: ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 (U6A022)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MNFQAGGGQSPQQQQSLAAPGGGGSGGGGAGGGGQFGGAGPGAGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSRKGADPDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPSTAPGTSPRGANGLALERSNTQLGGTTETEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQSTALAVQTVRTARGNSFCVDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGNNPSAELHRSPSIL
Protein: GTP-binding protein, putative (Q38AM0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein bL21m
- 50S ribosomal protein L17, putative
- 60S ribosomal protein L17, putative
- Ribosomal protein
- 60S ribosomal protein L12, putative
- 60S ribosomal protein L12, putative
- Ribosomal protein L11, putative
- 60S ribosomal protein L2, putative
- 50S ribosomal protein L2, putative
Sequence:
MLQPCLRRMSKCSSHPFVDAVKVLISSGAGGDGASVMSHEHGNEFAGPGGGNGGRGGNVMLKGSKKVNDLSHIKAMGTQISAAPGSVGFARTAHGKKGKDLLLELPVGTTVVDVDTNEVVYDVDEDGVELLLLQGGQGGKGNAAFANKWHHSPTESTRGLPGNTMLAQLELKSLADVGLVGYPNAGKSSILSAISSSKPTIAPYAFTTKRPYVGFIYDLYGNTCRVADLPGLIEGAFENRGLGHRFLRHAERTQSLAYVIDMAESYNPSSSTKPLEPWEAVETLRRELEYYLPGLSSRAMMIFANKMDMYKDTKGNFLKEKAEELQRRVQLPVFPVSAALGIALGAEHPQAGFKCAVELMCKVVFQKKQRCKDMREAQRRLETFTLDKTFCDKNIGVFIPSGDTEQRKGDTSLVDQQFEPCGFSGLGEEFSAYQQATAARGRLHDFRDLTMKGRYWSLTRRNGERVTSEKWQ
Protein: Mitochondria-eating protein (Spermatogenesis-associated protein 18) (A0A140VKF4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
Interaction partners:
Sequence:
MAENLKRLVSNETLRTLQEKLDFWLKEYNTNTCDQNLNHCLELIEQVAKVQGQLFGILTAAAQEGGRNDGVETIKSRLLPWLEASFTAASLGKSVDSKVPSLQDTFDRERHKDPSPRDRDMQQLDSNLNSTRSQCNQVQDDLVETEKNLEESKNRSAISLLAAEEEINQLKKQLKSLQAQEDARHRNTDQRSSENRRSEPWSLEERKREQWNSLKQNADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQGRSSRSRSPSPAPRSRSCSRSRSASPSTAVKVRRPSPNRSKLSNVARKAALLSRFSDSYSQARLDAQCLLRRCIDKAETVQRIIYIATVEAFHVAKMAFRHFKIHVRKSLTPSYVGSNDFENAVLDYVICHLDLYDSQSSVNDVIRAMNVNPKISFPPVVDFCLLSDFIQEICCIAFAMQALEPPLDIAYGADGEVFNDCKYRRSYDSDFTAPLVLYHVWPALMENDCVIMKGEAVTRRGAFWNSVRSVSRCRSRSLSPICPRSQIGLNTMSRSRSPSPIRCGLPRF
Protein: Nanog (Nanog homeobox) (Nanog protein) (Ovary-expressed homeobox protein) (Zgc:193933) (A5JNG8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- POU domain, class 5, transcription factor 1
- Transcription factor Sox-2
- T-box transcription factor T-A
- T-box transcription factor Tb.
- Biklf
- Kruppel-like factor 4.
- Mesp-related bHLH transcription factor mesp-a.
- Transcription factor Sox-19b
- Mix-type homeobox gene 2
- Transcriptional regulator Myc-A
Sequence:
MADWKMPVSYNFNPSYHAYAYGLMYPQVSEHGVPNLSWPDAAYTHSGGVTAGYFTAQTAQSPPWSPENGGASSTYSQYPGHSQNGRLFLSYNKTEPDQKAKDAEQTSSDTPSDSEAHTPDSWSSASSREGVPLTNLNLPSWRDRDYETDSGSPDSGERNLTSTAGEEPVNLNLGVDTQPPLPALTASPVRPPTLPRKTRAAFSEEQMNALVNRFNVQRYLTPAEMKTLAGATGLTYKQVKTWFQNRRMKLKRHQRDSSWMTERYVVNAVPNTPASQSQFQSEPPGANQDHYINPQVREPVFKRSPPKTPFYPSYPQPRSPTQATSRPPGTWPLPPAVTHYEFPNPISYMPARDGSNAVNKESSPSPLATSPTAGLWATKGITLL
Protein: GH21114p (Highroad (EC 3.4.16.-)) (Q9W0N8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Zinc carboxypeptidase A 1
- RE65433p
- GH20109p
- Trypsin theta
- CG4734 protein
- Uncharacterized protein, isoform A
- Uncharacterized protein
- Trypsin epsilon
- trypsin
- trypsin
Sequence:
MAGRAIIALLALLGFAGLASVDARKGYGPGDQDWGFVDVRTGAHMFYWLYYTTANVSSYTERPLAIWLQGGPGASSTGYGNFEELGPLKLDGSYRDWTWVKDMNVMFIDNPVGSGFSYVDGSSYYTTNNKQIALDLVELMKGFYTNHPEFKTVPLHIFCESYGGKMAPEFALELDYAIKRGEIESNFVSVALGDPWTSPIDSVLSWAPFLLQLGIVDQDGHDKIEASALKTKDYVDREKWTQATLQWSSTQSVVLRESKGVDFYNVETPTLGDQYRLMSRAAMTPEEVMYRTLVKFDVDEDRDKLLEDLMLGPVTEALGINTGVKWGAQSGTTFTKLMGDFMKPAVDVVGELLNNTTVKVGVFSGGLDLICATPGAVNWIEAMEWSAKPSYQVSPRVGITVDRVLEGYEKTYGNFSMFWVNRAGHMVPADNPAAMSHILRHFTKFG
Protein: ADP-ribosylation factor-like protein 2 (Q06849)
Organism: Drosophila melanogaster (Fruit fly)
Function: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Interaction partners:
- Tubulin-specific chaperone D
- Protein unc-119 homolog
- Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta
- Tubulin-specific chaperone E
- Tubulin-binding cofactor B
- Protein Mabiki
- Protein Mabiki
- RT10714p
- LD34582p
- Tubulin beta chain
Sequence:
MGFLTVLKKMRQKEREMRILLLGLDNAGKTTILKRFNGEPIDTISPTLGFNIKTLEHNGYTLNMWDVGGQKSLRSYWRNYFESTDGLVWVVDSADRMRLESCGQELQVLLQEERLAGATLLVLCNKQDLPGALSSNEIKEILHLEDITTHHWLVAGVSAVTGEKLLSSMDWLIADIAKRIFTLD
Protein: Neurotensin receptor type 2 (NT-R-2) (NTR2) (Low-affinity levocabastine-sensitive neurotensin receptor) (NTRL) (P70310)
Organism: Mus musculus (Mouse)
Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Neurotensin/neuromedin N
- Neurotensin receptor type 1
- Neuromedin-U
- Sortilin
- BDNF/NT-3 growth factors receptor
Sequence:
METSSLWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFALGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLISVPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEMERADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFVLPLALTAFLNGITVNHLVALYSQVPSASAQVNSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTDELYDFYHYFYMVTNTLFYVSSAVTPVLYNAVSSSFRKLFLESLSSLCGEQRSVVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV
Protein: Taste receptor type 2 member 41 (T2R41) (T2R12) (Taste receptor type 2 member 126) (Q9JKE7)
Organism: Rattus norvegicus (Rat)
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MLSTVSVFFMSIFVLLCFLGILANGFIVLMLSREWLWRGRLLPSDMILLSLGTSRFCQQCVGLVNSFYYSLHLVEYSRSLARQLISLHMDFLNSATFWFGTWLSVLFCIKIANFSHPAFLWLKWRFPALVPWLLLGSILVSFIVTLMFFWGNHTVYQAFLRRKFSGNTTFKEWNRRLEIDYFMPLKLVTTSIPCSLFLVSILLLINSLRRHSQRMQHNAHSLQDPNTQAHSRALKSLISFLVLYALSYVSMVIDATVVISSDNVWYWPWQIILYLCMSVHPFILITNNLKFRGTFRQLLLLARGFWVT
Protein: Inter-alpha-trypsin inhibitor heavy chain 4 (D3ZFC6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKSPAPAHMWNIVLVLLSLLAVLPITTTEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRADTVQEATFQVELPRKAFITNFSMIIDGVTYPGVVKEKAEAQKQYTAAVGRGESAGLVKTTGRKTEQFEVSVNVAPGSKTTFELIYQELLQRRLGMYELLLKVRPEQLVKHLQMDIYIFEPQGISTLETESTFMTQELANALTTSQNKTKAHIQFKPTLSQQRKSQNEQDTVLDGDFTVRYDVDRSSTGGTIQIENGYFVHHFAPEDLPTMAKNVLFVIDKSGSMAGKKIQQTREALIKILKDLSTQDQFNIIVFSGEANQWEQLLVQATEENLNRAVDYASKIPAQGGTNINKAVLSAVELLDKSNQAELLPSKSVSLIILLTDGEPTVGETNPKIIQKNTQEAINGRYSLFCLGFGFDVNYPFLEKLALDNGGLARRIYEDSDSALQLQDFYQEVANPLLSSVTFEYPSNAVEDVTRYNFQHHFKGSEMVVAGKLRDQGPDVLLAKVSGQMHLQNITFQTEASIAQQEKEFQGPKYIFHNFMERLWALLTIQQQLEQRISASGAELEALEAQVLNLSLKYNFVTPLTHMVVTKPEDQEQFQVAEKPTEVDGGVWSILSAVQRHFKTPTTGSKLLTSRLRGNRFQTLSRLGDGLVGSRQYMPPPGLPGPPGLPGPPGPPGHPHFASSIDYGRQPSLGRVLDLPSLSSQDPAGPSLAMLPKVVEQGTAASDHPRAPTIILPLPGSGVDQLCVDILHSEKPMKLFVDINQGLEVVGKYEKNIGFSWIEVTILKPHLQVHATPERLVVTRGRKNSEYKWKKTLFSVLPGLKMTMDKTGLLQLSGPDKVTISLLSLDDPQRGLMLLLNDTHHFSNDITGELGQFYQDIIWDDTKQTVRVLGIDYPATRELKLSYQDGFPGTEISCWTVKI
Protein: 4-hydroxyphenylpyruvate 3-dimethylallyltransferase (EC 2.5.1.111) (4HPP 3-dimethylallyltransferase) (Aromatic prenyltransferase CloQ) (Clorobiocin biosynthesis protein Q) (Q8GHB2)
Organism: Streptomyces roseochromogenus subsp. oscitans
Function: Magnesium-independent aromatic prenyltransferase that catalyzes the irreversible transfer of a dimethylallyl group to 4-hydroxyphenylpyruvate to produce the ring A structure in the clorobiocin biosynthesis pathway. Clorobiocin is an aminocoumarin family antibiotic.
Interaction partners:
Sequence:
MPALPIDQEFDCERFRADIRATAAAIGAPIAHRLTDTVLEAFRDNFAQGATLWKTTSQPGDQLSYRFFSRLKMDTVSRAIDAGLLDAAHPTLAVVDAWSSLYGGAPVQSGDFDAGRGMAKTWLYFGGLRPAEDILTVPALPASVQARLKDFLALGLAHVRFAAVDWRHHSANVYFRGKGPLDTVQFARIHALSGSTPPAAHVVEEVLAYMPEDYCVAITLDLHSGDIERVCFYALKVPKNALPRIPTRIARFLEVAPSHDVEECNVIGWSFGRSGDYVKAERSYTGNMAEILAGWNCFFHGEEGRDHDLRALHQHTESTMGGAR
Protein: Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) (Q2TBE6)
Organism: Mus musculus (Mouse)
Function: Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9BTU6}; Lipid-anchor {ECO:0000250|UniProtKB:Q9BTU6}. Membrane raft {ECO:0000250|UniProtKB:Q9BTU6}. Endosome {ECO:0000250|UniProtKB:Q99M64}. Endosome membrane {ECO:0000250|UniProtKB:Q9BTU6}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q99M64}. Cell projection, dendrite {ECO:0000269|PubMed:21998198}. Presynaptic cell membrane {ECO:0000269|PubMed:21998198}. Synapse, synaptosome {ECO:0000269|PubMed:21998198}. Mitochondrion {ECO:0000269|PubMed:21998198}. Membrane {ECO:0000269|PubMed:19581584}; Lipid-anchor {ECO:0000250|UniProtKB:Q9BTU6}. Cell membrane {ECO:0000250|UniProtKB:Q9BTU6}. Perikaryon {ECO:0000269|PubMed:21998198}. Cell projection, neuron projection {ECO:0000269|PubMed:21998198}. Note=Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. Transported from neuronal cell body to neuron projections and neurite tips in a BLOC-1- and AP-3-complexes-dependent manner (PubMed:21998198). {ECO:0000269|PubMed:21998198}.
Interaction partners:
- Phosphatidylinositol 4-kinase alpha
- Phosphatidylinositol 4-kinase beta
- Phosphatidylinositol-3-phosphatase SAC1
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
- Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Sequence:
MDETSPLVSPERAQPPEYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPCSPGHDRERQPLLDRARGAAAQGQTHTVAVQAQALAAQAAVAAHAVQTHRERNDFPEDPEFEVVVRQAEVAIECSIYPERIYQGSSGSYFVKDSQGRIVAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDCPMDNSSCRDTDWVMVREPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFIKDLEEDLYELFKRDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSASESYTQSFQSRKPFFSWW
Protein: Homeobox-leucine zipper protein HDG2 (HD-ZIP protein HDG2) (Homeodomain GLABRA 2-like protein 2) (Homeodomain transcription factor HDG2) (Protein HOMEODOMAIN GLABROUS 2) (Q94C37)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor (By similarity). Involved, together with PDF2, in the regulation of flower organs development by promoting the expression of APETALA 3 (AP3) in the epidermis and internal cell layers of developing flowers.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein BRANCHLESS TRICHOME
- Transcription factor MUTE
- At4g14500
- Pleckstrin homology
- Transcription factor SPEECHLESS
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
- Protein EPIDERMAL PATTERNING FACTOR 1
- ENHANCED DISEASE RESISTANCE protein
- At1g56580/F25P12_18
- At3g13062
Sequence:
MFEPNMLLAAMNNADSNNHNYNHEDNNNEGFLRDDEFDSPNTKSGSENQEGGSGNDQDPLHPNKKKRYHRHTQLQIQEMEAFFKECPHPDDKQRKQLSRELNLEPLQVKFWFQNKRTQMKNHHERHENSHLRAENEKLRNDNLRYREALANASCPNCGGPTAIGEMSFDEHQLRLENARLREEIDRISAIAAKYVGKPVSNYPLMSPPPLPPRPLELAMGNIGGEAYGNNPNDLLKSITAPTESDKPVIIDLSVAAMEELMRMVQVDEPLWKSLVLDEEEYARTFPRGIGPRPAGYRSEASRESAVVIMNHVNIVEILMDVNQWSTIFAGMVSRAMTLAVLSTGVAGNYNGALQVMSAEFQVPSPLVPTRETYFARYCKQQGDGSWAVVDISLDSLQPNPPARCRRRASGCLIQELPNGYSKVTWVEHVEVDDRGVHNLYKHMVSTGHAFGAKRWVAILDRQCERLASVMATNISSGEVGVITNQEGRRSMLKLAERMVISFCAGVSASTAHTWTTLSGTGAEDVRVMTRKSVDDPGRPPGIVLSAATSFWIPVPPKRVFDFLRDENSRNEWDILSNGGVVQEMAHIANGRDTGNCVSLLRVNSANSSQSNMLILQESCTDPTASFVIYAPVDIVAMNIVLNGGDPDYVALLPSGFAILPDGNANSGAPGGDGGSLLTVAFQILVDSVPTAKLSLGSVATVNNLIACTVERIKASMSCETA
Protein: Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) (O35609)
Organism: Mus musculus (Mouse)
Function: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MAQSRDTGNPFPDSGELDNPFQDPAVIQHRPSQQYATLDVYNPFENREPPPAYEPPAPAPAPLPPPSAPSVQSSRKLSPTEPRNYGSYSTQASAAAATAELLKKQEELNRKAEELDRRERELQHVALGGAGTRQNNWPPLPSFCPVKPCFFQDISMEIPQEFQKTVSTMYYLWMCSTLALLLNFFACLARFCVDTGSGSGFGLSMLWLLLFTPCSFVCWYRPMYKAFRSDSSFNFFVFFFIFFVQDVFFVLQAIGIPGWGFSGWVTALVVVGSKPAVAVLMLLVALLFTGIAVLGIVMLKRIHSLYRQTGASFQKAQQEFAAGVFSNPAVRTAAANAAAGAAENAFRAP
Protein: RNA-binding protein, putative (Q57Y27)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- BRCT domain-containing protein
- Transcription elongation factor S-II, putative
- Serine/threonine-protein kinase, putative
Sequence:
MGRRMRHAATALEKGANAHAVVDTASTGGRNGHVFADHITSPPGRSFRVDSAPPPADVTRNCFTYCGPDAGSDPQKRLHQQFKALPKEERQRIAAQSAEETDAIARTVHLRFLPTGMLQSELAALCAQCGEYLRVRICGNSTNTQNWIYGFVEFADRSGAAAMMRQSGLELPNGPGKPPLRLKCNAAKQPIVDRVFHDASPEGNVTCIFGSGNFANRTLKEAVDSYYNLKRKEGNMGAAQARMNNSSHSNNGNGSSGWSSKHNNNDNHHNHNHDHHHKNHHNNNNGGDGKDQRASLPPIITETHNWVEYTAPTSSLIDQGSPCNSVLGAESPPIASQQQPSPGCVDVPPVNDAKWPSSGSYLFDSPVYFLPCPSPVSNFGHGAYDVEFAGCKGKFSSLLGFAPKHNEFGPTPQLPQYANLQQLVDRARTLVLTAMGYAQVFVVTRERSHDAVGALRRLYELTAPCVTPQALNDFRKASSTASDEGMEMLQQRLLQLRLLACLLLSLLYSIKGDCEEMLQAVRNAVACCNVIPTVPLCRKGASVDAKRVETPAAPGDWFNVVGSREGGPSNSDNGNENENDEEETKSVVGFGQAPKEDTVPVFNPLAHVLDLFGDVSIGPEAGAEGRPPASAIGSATGVETAYHRCMRFHSYVLNVFLTIGFAMEDTQPVVARCVYVLVHRRAKELFGEAPPELERALQEGGIHHLRPVFLPELRHDTFVETFFTNFDVNSAGAAGEGMWFYLPPEHMVRTFGVDR
Protein: Runt-related transcription factor (E1BAD4)
Organism: Bos taurus (Bovine)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR009374}.
Interaction partners:
- ETS proto-onco 1, transcription factor
- Core-binding factor subunit beta
- RUNX1 partner transcriptional co-repressor 1
- Histone deacetylase 1
- Interleukin-3
- Tyrosine-protein phosphatase non-receptor type
- Macrophage colony-stimulating factor 1 receptor
- MDS1 and EVI1 complex locus
- GATA binding protein 1
- Histone deacetylase
Sequence:
MASDSMFESFPSYPQCFMRECVHGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVDVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTASDLTAFGDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMSSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVSGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPAARLEEAVWRPY
Protein: Albumin-2 (PA2) (PA2-like protein) (P86782)
Organism: Lens culinaris (Lentil) (Cicer lens)
Function: Binds hemin and thiamine.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P08688}.
Interaction partners:
Sequence:
TLTGYIANFSVLNXEAYLFINDKYVLLDYAPGTXNDK
Protein: GH12331p (Q95T89)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MHSPHAEDWTLRIRYAQRKDSGIYECQISTTPPIGHSVYLNIVEPVTDIIGGPELHINRGSTINLTCIVKFAPEPPPTVIWSHNREIINFDSPRGGISLVTEKGVLTTSRLLVQKAITQDSGLYTCTPSNANPTSVRVHIVDGEHPAAMHTGNNGNSTASQPPVLLPLVLLTCSTLMLLQLVASCSTLVPATPPGCRTVQQASTFAEEKAMGQRSNRNCQDLQELEESQDLRRRGVERSAVPGT
Protein: Serotonin N-acetyltransferase (Serotonin acetylase) (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) (AA-NAT) (Q29495)
Organism: Ovis aries (Sheep)
Function: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q16613}.
Interaction partners:
- Aromatic-L-amino-acid decarboxylase
- Amine oxidase [flavin-containing] A
- Amine oxidase
- Indoleamine 2,3-dioxygenase 2
- Indoleamine 2,3-dioxygenase 1
- N-acetyltransferase ESCO1
- N-acetyltransferase ESCO2
- Uncharacterized protein
- Amino acid transporter
Sequence:
MSTPSVHCLKPSPLHLPSGIPGSPGRQRRHTLPANEFRCLTPEDAAGVFEIEREAFISVSGNCPLNLDEVQHFLTLCPELSLGWFVEGRLVAFIIGSLWDEERLTQESLALHRPRGHSAHLHALAVHRSFRQQGKGSVLLWRYLHHVGAQPAVRRAVLMCEDALVPFYQRFGFHPAGPCAIVVGSLTFTEMHCSLRGHAALRRNSDR
Protein: ATP-dependent DNA helicase Q-like 1 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ1) (RecQ-like protein 1) (AtRecQ1) (AtRecQl1) (Q9FT74)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: 3'-5' DNA helicase that may play a role in the repair of DNA.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA mismatch repair protein MLH1
- AT5G19950 protein
- Flap endonuclease 1
- Serine/threonine-protein kinase ATR
- Exonuclease 1
- DNA repair endonuclease UVH1
- DNA replication ATP-dependent helicase/nuclease JHS1
- DNA topoisomerase 3-alpha
- DNA repair protein XRCC3 homolog
- Crossover junction endonuclease MUS81
Sequence:
MKDQDLELEKVRLISLATKLGFDEDSAKKCLDRFVDLYGDDGRDFITVELCGDDFLAALADFEEGTEEWDDIQAIESEAQGNLAEMFDKSTNPSDNGFDTDDDDDDSRVEVHVIEDSPEPKKKPEIVELDSSSDLEDVETRFKVPRRSQTCSRSMDYSMEDSVSTISGRKPSVQISNKDHETPSYEELQALDDLEFANLVIFGNKVFRPLQHQACRASMERKDCFVLMPTGGGKSLCYQLPATLKAGVTIVISPLLSLIQDQIVALNLKFGIPATFLNSQQTSSQAAAVLQELRRDNPSCKLLYVTPEKIAGSSSFLETLRCLDRKGLLAGFVVDEAHCVSQWGHDFRPDYRELGCLKQNFPRVPVMALTATATESVCQDVLKSLRIPRAPVLKMSFDRINLKYEVIVKTKEPLKQLQELLRDRFKDQSGIVYCLSKSECVDVAKFLNEKCKVKTVYYHAGVPAKQRVDVQRKWQTGEVRIVCATIAFGMGIDKADVRFVIHNTLSKAVESYYQESGRAGRDGLQAQCICLYQKKDFSRVVCMLRNGQGRNMDRFKSAMAQAKKMQQYCELKTECRRQMLLEYFGESFDRMICKSSLNPCDNCERS
Protein: DeHydrogenases, Short chain (O61709)
Organism: Caenorhabditis elegans
Interaction partners:
- Fatty acid synthase
Sequence:
MSCALVIGATSTLGKAVVRRLAFTGYKVAAAADCPNSVGKVAEDNIKVGGDVTAFSLDVANAEHRKELITKVAEKLGGLDTLIIVPPQNEVLGEIIETSGEDFDKLFANNLTTPFRLSQAAMSTLAKSQNGSIIYLTSCFGFTPSIDMGLYSVASSSVLSLTKSVAQSAAKQGVRVNSVVSGMIEGDGTGAVWDHASGEEARQIKQHLESMIPLGRLGRPSDVASYVEFLASTKARYITGENCIVGGGVSYRL
Protein: Ethylene-responsive transcription factor LEP (Protein LEAFY PETIOLE) (Q9M644)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cell division-promoting factor involved in leaf blade differentiation, inflorescence branching, as well as in carpel and silique shape. Promotes the number of xylem cells. Regulates positively the gibberellin signaling pathway leading to germination, hypocotyl elongation, and leaf expansion. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- CRS1 / YhbY
- ATP-dependent DNA helicase At3g02060, chloroplastic
Sequence:
MNTTSSKSKKKQDDQVGTRFLGVRRRPWGRYAAEIRDPTTKERHWLGTFDTAEEAALAYDRAARSMRGTRARTNFVYSDMPPSSSVTSIVSPDDPPPPPPPPAPPSNDPVDYMMMFNQYSSTDSPMLQPHCDQVDSYMFGGSQSSNSYCYSNDSSNELPPLPSDLSNSCYSQPQWTWTGDDYSSEYVHSPMFSRMPPVSDSFPQGFNYFGS
Protein: Protein ECM34 (Extracellular mutant protein 34) (P38728)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in cell wall organization and biogenesis.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Sulfite efflux pump SSU1
- Putative uncharacterized protein YHL042W
- Uncharacterized protein YHL041W
- DUP240 protein DFP4
Sequence:
MEGRKSEDEKNEAALACDVFESSNAKLPKNVFRSSFTWYCYEVINRSAFHIWLLLCLTLIVGWKVFSGIGGRRPSDSNMDGPQTKHKRNPGFLRRHSTIVILVISLAVSFSWEAFKMYRERTFGKQITQFAKEIIKSAPSTDMESWDRVAADFNSYMYENKLWNTEYFFC
Protein: Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] (P55084)
Organism: Homo sapiens (Human)
Function: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21527675}. Mitochondrion inner membrane {ECO:0000269|PubMed:21527675}. Mitochondrion outer membrane {ECO:0000269|PubMed:21527675}. Endoplasmic reticulum {ECO:0000269|PubMed:21527675}. Note=Protein stability and association with membranes require HADHA. {ECO:0000269|PubMed:29915090}.
Interaction partners:
- Peroxisomal bifunctional enzyme
- Trifunctional enzyme subunit alpha, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 1
- Enoyl-CoA hydratase, mitochondrial
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Peroxisomal acyl-coenzyme A oxidase 3
- Enoyl-CoA delta isomerase 2
Sequence:
MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDGVRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK