wanglab/gogpt-training-data huggingface dataset:
Protein: Histocompatibility 2, T region locus 13 (V9GXR0)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAQRTLFLLLAAALTMIETRAGPHSMRYFETAVFRPGLGEPRFISVGYVDNTQFVSFDSDAENPRSEPRAPWMEQEGPEYWERETQIAKDNEQSFGWSLRNLIHYYNQSKGGFHTFQRLSGCDMGLDGRLLRGYLQFAYDGRDYITLNEDLKTWMAADLVALITRRKWEQAGAAELYKFYLEAECVEWLRRYLQLGKETLLRTEPPPSTGSNMVNIAVLVVLGAVIIIEAMVAFVLKSSRKIAILPGPAGTKGSSAS
Protein: Beta-1,3-glucan-binding protein 1 (BGBP-1) (Beta-1,3-glucan recognition protein 1) (BetaGRP-1) (Q9NJ98)
Organism: Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Function: Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade. Causes aggregation of invading microorganisms.
Subcellular location: Secreted {ECO:0000269|PubMed:10713054}.
Interaction partners:
Sequence:
MLKSVFVLFLVNYLNSVRCLEVPDAKLEAIYPKGLRVSIPDDGYTLFAFHGKLNEEMEGLEAGHWSRDITKAKNGRWIFRDRNAKLKIGDKIYFWTYILKDGLGYRQDNGEWTVTGYVNEDGEPLDANFEPRSTASTAAPPQAGAGQAPGPSYPCELSVSEVSVPGFVCKGQMLFEDNFNKPLADGRIWTPEIMFPGEPDYPFNVYMKETDNLHVGNGNLVIKPMPLVTAFGEDAIWKTLDLSDRCTGLLGTAQCKRDPSDAIIVPPIVTAKINTKKTFAFKYGRVEISAKMPRGDWLVPLIQLEPVNKNYGIRNYVSGLLRVACVKGNTEYIKTLVGGPIMSEAEPYRTANLKEFISNEPWTNEFHNYTLEWSPDAITMAVDGIVYGRVTAPAGGFYKEANEQNVEAAARWIQGSNIAPFDDMFYISLGMDVGGVHEFPDEAINKPWKNTATKAMVNFWNARSQWNPTWLESEKALLVDYVRVYAL
Protein: Eugenol O-methyltransferase (EC 2.1.1.146) (O-methyltransferase 1) (SbOMT1) (A8QW52)
Organism: Sorghum bicolor (Sorghum) (Sorghum vulgare)
Function: O-methyltransferase. Substrate preference is eugenol >> orcinol monomethyl ether > resorcinol monomethyl ether.
Interaction partners:
Sequence:
MASYTSTSGQFAVGKVAAANQDDETCMHALKLLGGLAVPFTIKAVIELGIMDLLLAADRAMTAEALTAALLCPAPAPAAAAAMVDRMLRFLASHGVVRCATESEELGSDDGKSCRRYAAAPVCKWFARGGGVESVVPMGFWMTSTTNMETWHNIKDGVLAGETPFDKAYGMPVFEYLGANGTMNTLFNEAMASHSMIITKRLLEVFRGFENYSVLVDVGGGNGTTMQMIRSQYENISGINYDLPHVIAQASPIEGVEHVAGNMFDNIPRGDAIILKWILHNWGDKECVKILKNCYTALPVNGTVIILEYILPETPEETLASQLAFDFDLGMMLFFGASGKERTEKELLELAREAGFSGDYTATYIFANVWAHEFTK
Protein: Homeobox protein Rhox5 (Homeobox protein Pem) (Placenta and embryonic expression protein) (Reproductive homeobox on chromosome X 5) (P52651)
Organism: Mus musculus (Mouse)
Function: Transcription factor required for differentiation of embryonic stem cells (ESCs) into primordial germ cells.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Eppin
Sequence:
MEAEGSSRKVTRLLRLGVKEDSEEQHDVKAEAFFQAGEGRDEQGAQGQPGVGAVGTEGEGEELNGGKGHFGPGAPGPMGDGDKDSGTRAGGVEQEQNEPVAEGTESQENGNPGGRQMPLQGSRFAQHRLRELESILQRTNSFDVPREDLDRLMDACVSRVQNWFKIRRAAARRTRRRATPVPEHFRGTFECPACRGVRWGERCPFATPRF
Protein: Uncharacterized protein (Q57UI5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQHHFHLNRSFDMQLSPVAASIIDWAPAGRTGTVGNSHTPACSLPTVGVNGSHTHAVDSTSLSGAAKLKPAENLSGMRVLHRCTRQLLANSCVLVPIFSRGTFNVNAGLLASLGLTGGWNDACSRPSGFHANDVLQLEATWGKRQWAGIFNLVCFSWMSTTLPLFEFITVSPRTDSSLQVDRLMFNWSGFWRVFVSGDGSRRNSLISMDSPAERFVADVPVAPTGKLPDESKLGGVTGVDKKHDGLSTTPPITSNGDDTRRGGAISTGKKVKVGNTSGNTTSMNGDSGSGTAGVCMKKREEVAEPVSGSSSELCAETQKVGRWWRIRELRCGVGVALKNDIVSAANAYFGYSFHLGRALTFSSHVDVLRRGCYSVTCSTDRFDLATRLRVNHITSHFTEMDAGIGWRPLRHVPGFTCRLSYSMGRTSMGFTARDVTTHWGLAAHRTETPVQATAVLPPPLSSLPVPVAVESRGALLQLWDASVDWGLSAAHLVLGTLLPSLTGSAAAGRRVVKEGEEVEVPEHKPRQWNRLSRAFLAGVSYCKASVTQAKFDLTMGVATQQPRQSRPLRFFFVVSAY
Protein: Kis1p (Q59X47)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- 5'-AMP-activated protein kinase subunit gamma
- Carbon catabolite-derepressing protein kinase
- Protein SDS23
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Protein phosphatase regulator
- non-specific serine/threonine protein kinase
- Kis2p
Sequence:
MLSPKSTNQEAPATAPLDDINTTKDVSMVDVSKAEGENQQPPRRKSTIILTDEIDLDRMNIDNKESDKSNEQGDKMHIDRSLSNLNQQQHSQSSQSEPSQPEQQQQQQQQQQQQQQQPVAPDANIAVPVDIKWVQGGQKVYVTGSFTGWRKMIGLVKQPDDNFMITLGLPVGTHRFRFVVDNELRFSDFLPTATDQMGNFVNYIEITPENVQQHLLQEKEESNNESQQQELEKQQAKTGDKTSSQQASRRSSVSRSRSNSMWGLTNDDDDMGDGYSRYHDDESNALDEKTYQYIKDIPPIFTDPKVMEQYYVAIDKQSRNNNGQQQAWLHPPQLPPHLESVILNNFNNTENNSGALPIPNHVVLNHLATTSIKHNTLAVASIVRYKRKYLTQVLYAPLQQASSSSTTQEQQS
Protein: Antitoxin VapB40 (P9WFC3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC40. Upon expression in E.coli partially counteracts the ribonuclease activity of non-cognate toxins MazF6 and MazF9.
Interaction partners:
- Ribonuclease VapC40
Sequence:
MRTTIDVAGRLVIPKRIRERLGLRGNDQVEITERDGRIEIEPAPTGVELVREGSVLVARPERPLPPLTDEIVRETLDRTRR
Protein: Fucosyltransferase (EC 2.4.1.-) (Q9P1W6)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}. Golgi apparatus, Golgi stack membrane {ECO:0000256|RuleBase:RU003832}; Single-pass type II membrane protein {ECO:0000256|RuleBase:RU003832}.
Interaction partners:
Sequence:
MDPLGAAKPQWPWRRCLAARLFQLLVAVCFFSYLRVSRDDATGSPRAPSGSSRQDTTPTRPTLLILLWTWPFHIPVALSRCSEMVPGTADCHITADRKVYPQADTVIVHHWDIMSNPKSRLPPSPRPQGQRWIWFNLEPPPNCQHLEALDRYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAWFT
Protein: Exosome complex component rrp42 (Ribosomal RNA-processing protein 42) (O60124)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. ski6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Exosome complex component rrp43
- Exosome complex exonuclease dis3
- Exosome complex component rrp40
- Exosome complex component ski6
- Exosome complex component csl4
- Exosome complex component mtr3
- Exosome complex component rrp46
- Exosome complex component rrp45
- Exosome complex component rrp4
- Exosome complex protein C1739.07
Sequence:
MQLSLPELSYTHKSITEFEPAIRNDGRSIDQLRPLSGQVDVLPGTNGSARVKWASSVEIVIGVKAEVGDATPEGGKYVASVEISPSVSIQNRETDEIPSFLTSALQDLLNALAVDYLKFTPSKAWIIHVDAVVILSSSPYENILSALSLAAYLALQTTRLPKISTPNVTDITIGSTKYEPSEEYDVDSEWENALPLQGLELMSVIILVSSIDQVIIVDPTIEESSVAQVTYAIGVQASGAISYTRVVGTGGGYASTGRAITVERYIELLETASTVGTKLLNASSDILSFKGLGFFDILP
Protein: Oligopeptide transport ATP-binding protein OppF (EC 7.4.2.6) (P77737)
Organism: Escherichia coli (strain K12)
Function: Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:P08007}; Peripheral membrane protein {ECO:0000250|UniProtKB:P08007}.
Interaction partners:
- Periplasmic oligopeptide-binding protein OppA
- Oligopeptide transport ATP-binding protein OppD
- Oligopeptide transport system permease protein OppB
- Oligopeptide transport system permease protein OppC
- Dipeptide transport system permease protein DppC
- Probable D,D-dipeptide transport system permease protein DdpC
- Nickel transport system permease protein NikC
- Glutathione transport system permease protein GsiD
- Periplasmic murein peptide-binding protein MppA
- Putrescine export system permease protein SapC
Sequence:
MNAVTEGRKVLLEIADLKVHFEIKDGKQWFWQPPKTLKAVDGVTLRLYEGETLGVVGESGCGKSTFARAIIGLVKATDGHVAWLGKELLGMKPDEWRAVRSDIQMIFQDPLASLNPRMTIGEIIAEPLRTYHPKMSRQEVRERVKAMMLKVGLLPNLINRYPHEFSGGQCQRIGIARALILEPKLIICDEPVSALDVSIQAQVVNLLQQLQREMGLSLIFIAHDLAVVKHISDRVLVMYLGHAVELGTYDEVYHNPLHPYTRALMSAVPIPDPDLEKNKTIQLLEGELPSPINPPSGCVFRTRCPIAGPECAKTRPVLEGSFRHSVSCLKVDPL
Protein: Glycoprotein (J7H5L9)
Organism: CAS virus
Subcellular location: Host cell membrane {ECO:0000256|ARBA:ARBA00004165}.
Interaction partners:
Sequence:
MHYPWLHSRGRTKCEAHTAKALIIILLTANCKALIAEMLQAAAGNDSSICHGMMFTEPVGSFLGINPNTTDDPFELHALSLNQNVTDKIMIFQNGLKLFGSETRNYSITSGPGLLVGFFGHSRSGVYKNLTFTNNTTFKICVSCKSRFNITLVVYNKFTKKASTTICPDEFVRKKRSDVIVSYNLTCVILHNKNMITHHKTALNAEFSPRGLQQLSTKNDVEPGCDSNVGIFGHSSGTDAGWGIAGFFTLGITNSLQISEIEHVTDAIACKIIKTANYTTNALFLLNKEESEIRDHVVEHELALNYLLAHQGGLCNVVKGPMCCSDIDDFSKNVSDMIDKVHEEMKKFYHEPDPFGGLGSIGFFGTLFGHILQWIPIILLTIFMCFICSWVKK
Protein: Sulfite reductase [NADPH] subunit beta (EC 1.8.1.2) (Extracellular mutant protein 17) (P47169)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Adenylyl-sulfate kinase
- Phosphoadenosine phosphosulfate reductase
- Sulfite reductase flavoprotein component
- Sulfate adenylyltransferase
- Uroporphyrinogen-III C-methyltransferase
- Homocysteine/cysteine synthase
- Putative mitochondrial cysteine synthase
- Cystathionine gamma-synthase
- Thiosulfate sulfurtransferase TUM1
- Homocysteine/cysteine synthase
Sequence:
MTASDLLTLPQLLAQYSSSAPQNKVFYTTSTKNSHSSFKGLESVATDATHLLNNQDPLNTIKDQLSKDILTTVFTDETTLVKSIHHLYSLPNKLPLVITVDLNLQDYSAIPALKDLSFPILISSDLQTAISNADSSYKIATSSLTPVFHFLNLEKIGTSTAIEQDIDFPTLEIANEETKVALSEATDSLTNFELVKGKESITTVIVNLSPYDAEFSSVLPSNVGLIKIRVYRPWNFSKFLEILPSSVTKIAVLQGVSKKSQSNEFQPFLLDFFGNFNELVSRNIEQVVLTNIGNVNDYGNVINTVISNINKKEPDNNLFLGESNEKAEEQAEVTQLISSVKKVVNLEDAYIKVLKQLFSSNLQILNQFSSETIEPSNPEFGFGRFLKQEAQREELISLAKTSLDPSLYLSEDANKIVQLLSKWLSFNGRDLDEAQLQEANATGLEIFQLLQSNQDSSTVLKFLKIAPTSDSFIFKSSWLIGSDAWSYDLGHSGIQQVLSSRKNINVLLIDSEPYDHRKQNQDRKKDVGLYAMNYYSAYVASVAVYASYTQLLTAIIEASKYNGPSIVLAYLPYNSENDTPLEVLKETKNAVESGYWPLYRFNPVYDDPSTDKEAFSLDSSVIRKQLQDFLDRENKLTLLTRKDPSLSRNLKQSAGDALTRKQEKRSKAAFDQLLEGLSGPPLHVYYASDGGNAANLAKRLAARASARGLKATVLSMDDIILEELPGEENVVFITSTAGQGEFPQDGKSFWEALKNDTDLDLASLNVAVFGLGDSEYWPRKEDKHYFNKPSQDLFKRLELLSAKALIPLGLGDDQDADGFQTAYSEWEPKLWEALGVSGAAVDDEPKPVTNEDIKRESNFLRGTISENLKDTSSGGVTHANEQLMKFHGIYTQDDRDIREIRKSQGLEPYYMFMARARLPGGKTTPQQWLALDHLSDTSGNGTLKLTTRATFQIHGVLKKNLKHTLRGMNAVLMDTLAAAGDVNRNVMVSALPTNAKVHQQIADMGKLISDHFLPKTTAYHEVWLEGPEEQDDDPSWPSIFENRKDGPRKKKTLVSGNALVDIEPIYGPTYLPRKFKFNIAVPPYNDVDVLSIDVGLVAIVNPETQIVEGYNVFVGGGMGTTHNNKKTYPRLGSCLGFVKTEDIIPPLEGIVIVQRDHGDRKDRKHARLKYTVDDMGVEGFKQKVEEYWGKKFEPERPFEFKSNIDYFGWIKDETGLNHFTAFIENGRVEDTPDLPQKTGIRKVAEYMLKTNSGHFRLTGNQHLVISNITDEHVAGIKSILKTYKLDNTDFSGLRLSSSSCVGLPTCGLAFAESERFLPDIITQLEDCLEEYGLRHDSIIMRMTGCPNGCSRPWLGELALVGKAPHTYNLMLGGGYLGQRLNKLYKANVKDEEIVDYIKPLFKRYALEREEGEHFGDFCIRVGIIKPTTEGKYFHEDVSEDAY
Protein: Ribosome biogenesis protein RPF2 (P36160)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for biogenesis of the 60S ribosomal subunit.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12702244}.
Interaction partners:
- rRNA-processing protein CGR1
- Ribosome assembly factor MRT4
- Ribosome biogenesis protein ERB1
- Ribosome biogenesis protein NSA2
- Probable metalloprotease ARX1
- Nucleolar complex-associated protein 3
- Nucleolar GTP-binding protein 2
- Nuclear GTP-binding protein NUG1
- Ribosome biogenesis protein RLP24
- Ribosome biogenesis protein YTM1
Sequence:
MIRTVKPKNARAKRALVKREAKLVENVKQALFIPGQSCNKNLHDIMVDLSALKKPDMKRFNRKNDIHPFEDMSPLEFFSEKNDCSLMVLMTSSKKRKNNMTFIRTFGYKIYDMIELMVADNFKLLSDFKKLTFTVGLKPMFTFQGAAFDTHPVYKQIKSLFLDFFRGESTDLQDVAGLQHVISMTIQGDFQDGEPLPNVLFRVYKLKSYKSDQGGKRLPRIELVEIGPRLDFKIGRIHTPSPDMVTEAHKKPKQLEMKTKKNVELDIMGDKLGRIHMGKQDLGKLQTRKMKGLKSKFDQGTEEGDGEVDEDYEDEASYSDDGQEYEEEFVSATDIEPSAKRQKK
Protein: Aflatoxin B1 aldehyde reductase member 4 (EC 1.-.-.-) (AFB1 aldehyde reductase 3) (AFB1-AR 3) (Aldoketoreductase 7-like) (Q8NHP1)
Organism: Homo sapiens (Human)
Function: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).
Interaction partners:
Sequence:
MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYRNHFWKEHHFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLFAHECPNYFI
Protein: Nicotinamide N-methyltransferase (EC 2.1.1.1) (O55239)
Organism: Mus musculus (Mouse)
Function: Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases (By similarity). Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (By similarity). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway. Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase. Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Aldehyde oxidase 4
- Aldehyde oxidase 2
- Aldehyde oxidase 3
- Aldehyde oxidase 1
- Nicotinamide phosphoribosyltransferase
- NAD-dependent protein deacetylase sirtuin-1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- NAD-dependent protein deacetylase sirtuin-3
- NAD-dependent protein deacylase sirtuin-6
Sequence:
MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAVKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGAFDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVSLPPADCLLSTLCLDAACPDLPAYRTALRNLGSLLKPGGFLVMVDALKSSYYMIGEQKFSSLPLGWETVRDAVEEAGYTIEQFEVISQNYSSTTSNNEGLFSLVGRKPGRSE
Protein: Enoyl-CoA hydratase EchA19 (EC 4.2.1.-) (O53561)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Degradation of the cholesterol side chain involves 3 multistep beta-oxidation cycles, this may be involved in the second cycle (Probable). Hydrates 3-OCDO-CoA ((22E)-3-oxo-chol-4,22-dien-24-oyl-CoA) to make (22R)-HOCO-CoA (3-oxo-chol-4-ene-(22R)-hydroxy-24-oyl-CoA). Also acts on octenoyl-CoA. Not active on (E)-3-OCDS-CoA ((E)-3-oxocholest-4,24-dien-26-oyl-CoA) or 3-OPDC-CoA (3-oxo-4,17-pregnadiene-20-carboxyl-CoA). Hydrates the same substrate as ChsH3, but the 2 enzymes make different stereoisomers of the product.
Interaction partners:
- Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3
- Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4
- Steroid 3-ketoacyl-CoA thiolase
- Medium/long-chain-fatty-acid--CoA/3-oxocholest-4-en-26-oate--CoA ligase
- Cullin, a subunit of E3 ubiquitin ligase
- Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3
- Acyl-CoA dehydrogenase FadE26
- ChsH2 C-terminal OB-fold domain-containing protein
- 3-hydroxybutyryl-CoA dehydrogenase
- Acyl-CoA dehydrogenase FadE27
Sequence:
MATVESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPDIRCCILTGAGGYFCAGMDLKAATQKPPGDSFKDGSYGPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMGLIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPENEAFKIDTQIGIKVFLSDDAKEGPRAFAEKRAPNFQNR
Protein: Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50) (P50995)
Organism: Homo sapiens (Human)
Function: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28469040}. Melanosome. Nucleus envelope. Nucleus, nucleoplasm {ECO:0000269|PubMed:28469040}. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. {ECO:0000250}.
Interaction partners:
- Protein S100-A6
- Annexin A7
- Programmed cell death protein 6
- Butyrophilin-like protein 2
- Protein TFG
Sequence:
MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAANMSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDIYEIKEAIKGVGTDEACLIEILASRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLAQRDAQELYAAGENRLGTDESKFNAVLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEEGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKSLYHDISGDTSGDYRKILLKICGGND
Protein: Transcription factor LG2 (Protein LIGULELESS 2) (Protein TGACG (TGA) motif-binding protein LG2) (O49067)
Organism: Zea mays (Maize)
Function: Required for the formation of the blade-sheath boundary in leaves. Promotes flowering.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- Protein LIGULELESS 1
- Homeobox protein liguleless 3
- Protein LIGULELESS 1
- Homeobox protein liguleless 3
- Homeotic protein knotted-1
- BTB/POZ domain and ankyrin repeat-containing protein NPR1
Sequence:
MVQGEESSWRMERAALPLNQALAYGVQAHAAAAAAPPTCFLDFQPAAASAAYFGFGELEEALIHGGGAASAGGGVDPGVIIKNDVAQAKSAAGYLAGAGTGRPPTLEIFPSWPMRHQQQLHSGNSQSVGSTGTDSSSAQNTMSQMELVSPASSAPRQEVMMVTTDDYSYKPGLAAAPAAAAPPSFQQHHPLPLQLHGGEGGGDHDKRKHGSTRKDGKLVDAKTERRLAQNREAARKSRLRKKAYVQQLETSRIRLQQVEHELQRARSQGLFVGGCSAAGDMSSGAAMFDMEYARWLDDDTKRLAELRGGLQAHLLDGNLGLIVEECMQHYDELFQLKAALARSDVFHLLTGSWATPAERCFFWMGGFRPSELLKILIPQLDPLTEQQLLGICNLQQSSEQAEEALAQGLHQLHQSLADTVAAGTLNDGAAAPNYMNIMAVALEKLASLENFYQQADNLRHQTLHQMRRILTTRQAARCFLSIGEYYSRLRALSNLWASRPRDNFIGTESLSPTATELQALHHQQQNQFAGF
Protein: Farnesoic acid carboxyl-O-methyltransferase (EC 2.1.1.325) (SABATH methyltransferase FAMT) (Q9FYC4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May catalyze the production of the insect juvenile hormone methyl farnesoate (MeFA) to trigger defense against insect herbivory.
Interaction partners:
- Protein STRICTOSIDINE SYNTHASE-LIKE 7
- Eukaryotic aspartyl protease family protein
- RNA-binding
- Hydroxyproline-rich glycoprotein family protein
- Putative pectinesterase
- Glutaredoxin family protein
- Peptide methionine sulfoxide reductase B7
Sequence:
MSTSFTMIGGEGPNSYREHSKYQGALVIAAKEKINEAISTKLDIDFTSNLVNIADFGCSSGPNTFTAVQTLIDAVENKYKKESNIEGIEFQVFFNDSSNNDFNTLFKTLPPARLYFASGVPGSFFGRVLPKNSLHVGVSSYSLHFVSKVPKEIKDRDSLVWNKDIHCSGSSKEVVKLYLGQYKIDVGSFLTARAQELVSGGLLLLLGSCRPTGVQMFETVEGMMIDFIGSSLNEIANQGLIDQQKLDTFKLPIYAPNVDELKQIIEDNKCFTIEAFEKISHAKGEYPLDPEYLTSAFKVTVGGSVASLFGQDGMEKTYELVKEKTQEMLPQIAKAKPGMQYLIVLRRN
Protein: Growth arrest-specific protein 7 (GAS-7) (O60861)
Organism: Homo sapiens (Human)
Function: May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Calcium load-activated calcium channel
Sequence:
MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLEKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGSHRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI
Protein: Epoxide hydrolase 4 (EC 3.3.-.-) (Abhydrolase domain-containing protein 7) (Epoxide hydrolase-related protein) (Q8IUS5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MARLRDCLPRLMLTLRSLLFWSLVYCYCGLCASIHLLKLLWSLGKGPAQTFRRPAREHPPACLSDPSLGTHCYVRIKDSGLRFHYVAAGERGKPLMLLLHGFPEFWYSWRYQLREFKSEYRVVALDLRGYGETDAPIHRQNYKLDCLITDIKDILDSLGYSKCVLIGHDWGGMIAWLIAICYPEMVMKLIVINFPHPNVFTEYILRHPAQLLKSSYYYFFQIPWFPEFMFSINDFKVLKHLFTSHSTGIGRKGCQLTTEDLEAYIYVFSQPGALSGPINHYRNIFSCLPLKHHMVTTPTLLLWGENDAFMEVEMAEVTKIYVKNYFRLTILSEASHWLQQDQPDIVNKLIWTFLKEETRKKD
Protein: Protein translocase subunit SecE (Q8KZP4)
Organism: Thermus thermophilus
Subcellular location: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00422}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00422}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MFARLIRYFQEARAELARVTWPTREQVVEGTQAILLFTLAFMVILGLYDTVFRFLIGLLR
Protein: Chromosome transmission fidelity protein 18 (P49956)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Replication factor C subunit 2
- Chromosome transmission fidelity protein 8
- Replication factor C subunit 5
- Sister chromatid cohesion protein DCC1
- Replication factor C subunit 3
- DNA polymerase epsilon catalytic subunit A
- Checkpoint protein RAD24
- Telomere length regulation protein ELG1
- Replication factor C subunit 4
- DNA polymerase alpha-binding protein
Sequence:
MVDTAPYIGSLGRSSLFDTGDIEQAPGNNAIGINEEDIHAFVSSTGETVQLKKKPAKLATGNISLYTNPDTVWRSDDTYGININYLLDKIEASGDDRTNAQKTSPITGKIGSDTLWVEKWRPKKFLDLVGNEKTNRRMLGWLRQWTPAVFKEQLPKLPTEKEVSDMELDPLKRPPKKILLLHGPPGIGKTSVAHVIAKQSGFSVSEINASDERAGPMVKEKIYNLLFNHTFDTNPVCLVADEIDGSIESGFIRILVDIMQSDIKATNKLLYGQPDKKDKKRKKKRSKLLTRPIICICNNLYAPSLEKLKPFCEIIAVKRPSDTTLLERLNLICHKENMNIPIKAINDLIDLAQGDVRNCINNLQFLASNVDSRDSSASDKPACAKNTWASSNKDSPISWFKIVNQLFRKDPHRDIKEQFYELLNQVELNGNSDRILQGCFNIFPYVKYSDNGIRKPANISDWLFFHDLMYQSMYAHNGELLRYSALVPLVFFQTFGDIANKDDIRMKNSEYEQRELKRANSDIVSLIMRHISVQSPLMASFTDRKSLIFEILPYLDSMISSDFNKIRNLKLKQAIMEELVQLLKSFQLNLIQNRSEGFDVRGGLTIDPPIDEVVLLNPKHINEVQHKRANNLSSLLAKIEENRAKKRHIDQVTEDRLQSQEMHSKKVKTGLNSSSSTIDFFKNQYGLLKQTQELEETQKTIGSDETNQADDCNQTVKIWVKYNEGFSNAVRKNVTWNNLWE