wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized ABC transporter permease protein Rv0987 (O53900)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Probably part of an ABC transporter complex involved in host cell binding either through secretion of an adherence factor or through maintaining the architecture and integrity of the mycobacterial cell envelope. Could be required for host endothelial-cell invasion and/or intracellular survival.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Possible conserved exported protein
- Uncharacterized ABC transporter ATP-binding protein Rv0986
- Chaperone protein ClpB
Sequence:
MNDQAPVAYAPLWRTAWRRLRQRPFQYILLVLGIALGVAMIVAIDVSSNSAQRAFDLSAAAITGKSTHRLVSGPAGVDQQLYVDLRRHGYDFSAPVIEGYVLARGLGNRAMQFMGTDPFAESAFRSPLWSNQNIAELGGFLTRPNGVVLSRQVAQKYGLAVGDRIALQVKGAPTTVTLVGLLTPADEVSNQKLSDLIIADISTAQELFHMPGRLSHIDLIIKDEATATRIQQRLPAGVRMETSDTQRDTVKQMTDAFTVNLTALSLIALLVGIFLIYNTVTFNVVQRRPFFAILRCLGVTREQLFWLIMTESLVAGLIGTGLGLLIGIWLGEGLIGLVTQTINDFYFVINVRNVSVSAESLLKGLIIGIFAAMLATLPPAIEAMRTVPASTLRRSSLESKITKLMPWLWVAWFGLGSFGVLMLWLPGNNLVVAFVGLFSVLIALALIAPPLTRFVMLRLAPGLGRLLGPIGRMAPRNIVRSLSRTSIAIAALMMAVSLMVGVSISVGSFRQTLANWLEVTLKSDVYVSPPTLTSGRPSGNLPVDAVRNISKWPGVRDAVMARYSSVFAPDWGREVELMAVSGDISDGKRPYRWIDGNKDTLWPRFLAGKGVMLSEPMVSRQHLQMPPRPITLMTDSGPQTFPVLAVFSDYTSDQGVILMDRASYRAHWQDDDVTTMFLFLASGANSGALIDQLQAAFAGREDIVIQSTHSVREASMFIFDRSFTITIALQLVATVVAFIGVLSALMSLELDRAHELGVFRAIGMTTRQLWKLMFIETGLMGGMAGLMALPTGCILAWILVRIINVRSFGWTLQMHFESAHFLRALLVAVVAALAAGMYPAWRLGRMTIRTAIREE
Protein: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase subunit beta) (Acetyl-CoA carboxylase carboxyltransferase subunit beta) (EC 2.1.3.15) (Q0PC10)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|HAMAP-Rule:MF_01395}.
Interaction partners:
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
- Biotin carboxyl carrier protein of acetyl-CoA carboxylase
- Biotin carboxylase
- Pyruvate carboxylase B subunit
- Biotin carboxylase
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Malonyl CoA-acyl carrier protein transacylase
- Beta-ketoacyl-[acyl-carrier-protein] synthase III
- Putative 3-oxoacyl-[acyl-carrier-protein] synthase 3
Sequence:
MNFADIFSKIRRQQPSVKEAPNHWVKCQSCHALMYYKEIESCFNVCPKCNYHMRISADERIKLLSDEGSFIEYDANLEAIDPLKFVDSKSYKKRLSEGESKTGRKSSVISGECEINGLKTQLVVFDFSFMGGSLGSVEGEKIVRAIQRAITSKTSLVIVSASGGARMQESTYSLMQMSKTSAALKLLSKEKLPYISILTDPTMGGVSASFAWLGDLIIAEPEALVGFAGARVIKQTIGADLPEGFQKAEFLLEHGLIDAIVERGEQKQYLSDVLKFFSGK
Protein: MICOS complex subunit MIC10 (Q9W1B2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU363011}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU363011}.
Interaction partners:
- MICOS complex subunit Mic60
Sequence:
MSHEPQKPAKSAVKEPPVVSEETRTTDKCLADFCLKGGSGLIIGSAVTLFFTRPQTYPIWLGLGVGMGVAYDCCQARWNQQ
Protein: Noelin-3 (Olfactomedin-3) (Optimedin) (P63056)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000269|PubMed:22632720}. Synapse {ECO:0000305|PubMed:22632720}. Note=Isoform 2 is secreted more efficiently than isoform 1.
Interaction partners:
- Glutamate receptor 1
- Glutamate receptor 2
- Glutamate receptor 4
- Leucine-rich repeat transmembrane neuronal protein 4
- Noelin
- Neuritin
- von Willebrand factor C domain-containing protein 2-like
- Glutamate receptor 3
- Protein shisa-9
- Voltage-dependent calcium channel gamma-3 subunit
Sequence:
MSAPLLKLGAVLSTMAMISNWMSQTLPSLVGLNTTRLSAPDTLTQISPKEGWQVYSSAQDPDGRCICTVVAPEQNLCSRDAKSRQLRQLLEKVQNMSQSIEVLNLRTQRDFQYVLKMETQMKGLKAKFRQIEDDRKTLMTKHFQELKEKMDELLPLIPVLEQYKTDAKLITQFKEEIRNLSSVLTGIQEEIGAYDYEELHQRVLSLETRLRDCMKKLTCGKLMKITGPITVKTSGTRFGAWMTDPLASEKNNRVWYMDSYTNNKIVREYKSIADFVSGAESRTYNLPFKWAGTNHVVYNGSLYFNKYQSNIIIKYSFDLGRVLAQRSLEYAGFHNVYPYTWGGFSDIDLMADEIGLWAVYATNQNAGNIVISQLNQDTLEVMKSWSTGYPKRSAGESFMICGTLYVTNSHLTGAKVYYSYSTKTSTYEYTDIPFHNQYFHISMLDYNARDRALYAWNNGHQVLFNVTLFHIIKTEDDT
Protein: Serine protease 57 (EC 3.4.21.-) (Neutrophil serine protease 4) (NSP4) (Serine protease 1-like protein 1) (Q6UWY2)
Organism: Homo sapiens (Human)
Function: Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues.
Subcellular location: Cytoplasmic granule lumen {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. Secreted {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. Note=Stored in cytoplasmic granules and secreted as active enzyme in response to stimulation of neutrophils. {ECO:0000269|PubMed:22474388}.
Interaction partners:
- SH2 domain-containing protein 3C
- SH2 domain-containing protein 3A
- Cytospin-B
- Myeloperoxidase
Sequence:
MGLGLRGWGRPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRPPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVRRSSPQPGPLPGTTRPPGEAA
Protein: Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2) (O43374)
Organism: Homo sapiens (Human)
Function: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:11448776}. Cell membrane {ECO:0000269|PubMed:11448776}; Peripheral membrane protein {ECO:0000269|PubMed:11448776}. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
Interaction partners:
- RAS guanyl-releasing protein 1
- GTPase HRas
- GTPase NRas
- GTPase KRas
- Ras-related protein R-Ras
- Ras-related protein M-Ras
Sequence:
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
Protein: FI17948p1 (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform B) (Uncharacterized protein, isoform C) (Uncharacterized protein, isoform D) (Q9VY15)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase
Sequence:
MATGGGGSGHGGAGSAGNADHHKRNTFTSYVAPLPGDLRATADTNEWCLPSDLRDVHLAKPRLLHGEQIVASAPAYMYSPIDPMDSSGGSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFVPLHEKRNQAITAPLIDLYQENTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKLEPFKQQNISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMRHDLSFAYAHREPYYSTLGASGTSMYATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAGKYTVPPHFVIPKSCSVDRFLDLSRAFCDSRAAFWVYSYGSSAALVRLAELQPAAQQDTKSENVMLELVRKCDAGRQLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRSGVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDWGEQFSDKDKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATASSVPQDRYLQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDYQNFDDLPDAYYEFAGESRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATPTSGLTSVTGNLQLSTLSSFFPFGNPIAGDAPLQLYDILSSSSELLMETSSFLDKSSIV
Protein: ABC transporter domain-containing protein (Q19585)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Protein kinase domain-containing protein
- Tyrosine-protein phosphatase domain-containing protein
- Putative tyrosine-protein phosphatase B0280.11
- Phospholipid/glycerol acyltransferase domain-containing protein
- Tyrosine-protein kinase
- Protein kinase domain-containing protein
- Elongation of very long chain fatty acids protein
- HotDog ACOT-type domain-containing protein
- Histone H2A/H2B/H3 domain-containing protein
- DeHydrogenases, Short chain
Sequence:
MDSKSEEAEPLLKPKNVEDEGLITSLDVDPTQKSRSPTPKPTPIPVLINDTPVASEIEQVEKELAHSSERFRKPKTLSVTNDTESARIPSQVKTNAKKLVFQNIQAVVLKKKGVRQEILKKIDGVARPGELTFIMGSSGAGKTTLLNILTGRNLKNIETDGDIMINGRNMISNEMKKLSAYVQQDDVFIGTLTVRETLRFAAKLRSPSALGATELDSIVDELLVMMSLKKCENTKVGTMTEKSLSRGERKRLAFACEILTDPPILFCDEPTSGLDSFMSHQVIKALRQLTIEGKTVICTIHQPSTSVYHMADQLILLSQGHVAYAGPAKQVDAFFGRCGYPIPKFVSSPDHFMRVISHKSFETEDDYNKRIEKIVLEHDIMKKEQSTHSTLSSSRREHPETAPFTFPRTWTAQFFFIFQRSSIQLWRERSVLLVKLIQTLIMSIMIGSTYYGLEIDKKSLPSFKGFAFVSVQMMHMLFMMPAMTVFWKDYPVVVREFQANMYSPSAYYLAKTTADSIQYLVFPVIFSGILLGMTSLPYSVVIITNYLIINILLSLNACSVGQSFAAMCGHLATGMTVLPIVCVPLMVFGGFMITYEAIPWYFLPFAWVSWYKYGFEAITIVYFNHNSTISGCESNSSVATLKMSIDSNCTTGIEFIKAQAFEETHLWLDYTVILAVILFWKILGALLFTWRIRRA
Protein: Ureide permease 2 (AtUPS2) (Q9ZQ89)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Proton-coupled transporter that transports a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds, including allantoin, uric acid and xanthine, but not adenine. Mediates high affinity transport of uracil and 5-fluorouracil (a toxic uracil analog). Mediates transport of free pyrimidines and may function during early seedling development in salvage pathways, by the utilization of pyrimidines from seed storage tissue.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dihydropyrimidine dehydrogenase
- Dirigent protein 21
- Uracil phosphoribosyltransferase, chloroplastic
- Equilibrative nucleotide transporter 1
- Aspartate carbamoyltransferase, chloroplastic
- Uridine nucleosidase 1
- GDSL esterase/lipase At5g55050
- Beta-ureidopropionase
- Thymidine kinase b
Sequence:
MYLVESKGGAIACMLLALLSLGTWPAVLTLLERRGRLPQHTYLDYSITNLLAAIIIAFTFGQIGSTKPDSPNFITQLAQDNWPSVMFAMAGGIVLSLGNLSTQYAWALVGLSVTEVITSSITVVIGSTLNYFLDDKINKAEILFPGVACFLIAVCLGSAVHRSNADDNKAKLRDFETAKQEASGPSTEIGTNSSKDLETNVTTKPKEGTARFLIELENTRAIKVFGKRKIIGLAITFFAGLCFSLFSPAFNLATNDQWNRLKQGVPKLVVYTAFFYFSVSCFIIALILNVVFLYYPVLGLPKSSFKAYLNDWNGRYWAFLAGFLCGFGNGLQFMGGQAAGYAAADSVQALPLVSTFWGVVLFGEYRRSSRKTYLLLFCMLFMFISAVAVLMASSGHRK
Protein: Zinc finger CCCH domain-containing protein 8 (Q8N5P1)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
Subcellular location: Nucleus {ECO:0000269|PubMed:23932780}. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Interaction partners:
- Little elongation complex subunit 1
- Little elongation complex subunit 2
- RNA polymerase II elongation factor ELL
- AF4/FMR2 family member 4
- RNA polymerase II elongation factor ELL3
- Negative elongation factor B
- Negative elongation factor E
- RNA polymerase II elongation factor ELL2
- Parafibromin
- Transcription elongation factor SPT5
Sequence:
MDFENLFSKPPNPALGKTATDSDERIDDEIDTEVEETQEEKIKLECEQIPKKFRHSAISPKSSLHRKSRSKDYDVYSDNDICSQESEDNFAKELQQYIQAREMANAAQPEESTKKEGVKDTPQAAKQKNKNLKAGHKNGKQKKMKRKWPGPGNKGSNALLRNSGSQEEDGKPKEKQQHLSQAFINQHTVERKGKQICKYFLERKCIKGDQCKFDHDAEIEKKKEMCKFYVQGYCTRGENCLYLHNEYPCKFYHTGTKCYQGEYCKFSHAPLTPETQELLAKVLDTEKKSCK
Protein: Envelope glycoprotein L (gL) (P03212)
Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Function: The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. The heterodimer gH/gL targets also host EPHA2 to promote viral entry.
Subcellular location: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04034}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_04034}; Extracellular side {ECO:0000255|HAMAP-Rule:MF_04034}. Host cell membrane {ECO:0000250, ECO:0000255|HAMAP-Rule:MF_04034, ECO:0000269|PubMed:15534216, ECO:0000269|PubMed:7539502}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_04034}; Extracellular side {ECO:0000255|HAMAP-Rule:MF_04034}. Host Golgi apparatus, host trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04034}. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs. {ECO:0000255|HAMAP-Rule:MF_04034}.
Interaction partners:
Sequence:
MRAVGVFLAICLVTIFVLPTWGNWAYPCCHVTQLRAQHLLALENISDIYLVSNQTCDGFSLASLNSPKNGSNQLVISRCANGLNVVSFFISILKRSSSALTGHLRELLTTLETLYGSFSVEDLFGANLNRYAWHRGG
Protein: 2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase) (P09151)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01025}.
Interaction partners:
- 3-isopropylmalate dehydratase small subunit
- 3-isopropylmalate dehydrogenase
- Branched-chain-amino-acid aminotransferase
- 3-isopropylmalate dehydratase large subunit
- Dihydroxy-acid dehydratase
- Acetolactate synthase isozyme 1 large subunit
- Acetolactate synthase isozyme 3 large subunit
- Acetolactate synthase isozyme 3 small subunit
- Ketol-acid reductoisomerase
- Acetaldehyde dehydrogenase
Sequence:
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
Protein: T-complex protein 1 subunit theta (O96220)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit eta
- CCT-beta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit epsilon
- Phosducin-like protein 1, putative
- Heat shock protein 60
- 60 kDa chaperonin
Sequence:
MFSNKLGVNSILKDGYRIMKNNEDTILKNIEACKEICNILQTSLGPKCMNKLIINHIHKKIVSSDCITILNDMEINHPVVNILKKLSETINYEYGDFTNYAFTITCEILDKASFLIQQGFNINDILNGFVLGYKEIEKVLEEMIVWKVPNFYEEKELIKVLKSVMLTKNISNNYNFLIQLLAKCISTLMPEKIEDFDVDNIRVSKLNGGNIIDSEFLMGMVIAREANGIIKKKENANVIVLNCGLEGPTTETKGTVLLHNAEELINYTKGEELQMKKYIDNFKKANVDVIIVNGAISDIAQHFCDTNNIMTLKITSKFETLRICKLLNISSLIKLSTPQPEDIGKVSSIYVSEIASKKVTIINSKNKKVGTIILRGATFNLLDEVERCIHDGINSIKNAIKGNAFLHGGGCVEIQLCLALKKYANQLKGVDNYCVKIFAEAFYIIPKILARNAGYNTTDVLNELINEHNKGNTHSCININKDSHITSAQNNHIYDNYNCKKYAIHLAMEAVQTILKIDQIIMSKPAGGPKPRDKNPDYDEAF
Protein: Zinc finger protein 440 (Q8IYI8)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MDPVAFKDVAVNFTQEEWALLDISQRKLYREVMLETFRNLTSLGKRWKDQNIEYEHQNPRRNFRSLIEEKVNEIKDDSHCGETFTPVPDDRLNFQEKKASPEVKSCESFVCGEVGLGNSSFNMNIRGDIGHKAYEYQEYGPKPCKCQQPKKAFRYRPSFRTQERDHTGEKPNACKVCGKTFISHSSVRRHMVMHSGDGPYKCKFCGKAFHCLRLYLIHERIHTGEKPCECKQCGKSFSYSATHRIHKRTHTGEKPYEYQECGKAFHSPRSYRRHERIHMGEKAYQCKECGKAFTCPRYVRIHERTHSRKNLYECKQCGKALSSLTSFQTHVRLHSGERPYECKICGKDFCSVNSFQRHEKIHSGEKPYKCKQCGKAFPHSSSLRYHERTHTGEKPYECKQCGKAFRSASHLRVHGRTHTGEKPYECKECGKAFRYVNNLQSHERTQTHIRIHSGERRYKCKICGKGFYCPKSFQRHEKTHTGEKLYECKQRSVVPSVVPVPFDIMKGLTLERSPINASNVGKPSELCQSFECMVGLTLKRNPMSVSNDGKPSDLPHTFEYVVGHTMERSPMHVRNVGNPSDLPRTFEFMKGHKHT
Protein: Epsin-like protein (Q9NH51)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWKVRELADKVTNVVMNYTETEGKVREATNDDPWGPTGPLMQELAYSTFSYETFPEVMSMLWKRMLQDNKTNWRRTYKSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYTFTDEGGKDQGINVRHKVRELIDFIQDDDRLREERKKAKKNKDKYIGMSSDAMGMRSGGYSGYSGGSGGGGGGSGGYNDGDYRSSRGDNWYSDKSADKDRYEDDDTHYDGEREGSDSDSPSPRRNYRYNDRASPAEVASEAKPSSLNMNIRSKTVSSPVSKQPTSTASAKPALSQKKIDLGAAANFGKPAPGGAAGIHSPTHRDTPTSVDLMGGASPSPSTSKANNNTQSNNNDLLDDLFKTCSPPPGQEKTLNSAAVIVDDDDDFNPRASDASQQEFGDFASAFGQPSAGSTISEPPSTGLVPAANDEFADFAAFQGSTTSTSALDGNLLKTATPANDSFDLFNSAPTSTAAATTATDLLAGLGDLSIHQSMPMDNMMPPIPAVTGNNLLQPMSVTNNNNNTNGGAVPAAASVQSTAVGATWSGDLKGGKMNIDLDNLLMSKSGKPSAPAPSMNALKTNSPAKAPLNVQTGGGFPGLSPMTSPNIFGAPAPQQSIPQNQSAFANFGAFQQQQQNHSNNNNNSSSAFDLFQ
Protein: D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase (EC 3.1.3.82) (D,D-heptose 1,7-bisphosphate phosphatase) (HBP phosphatase) (P63228)
Organism: Escherichia coli (strain K12)
Function: Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Phosphoheptose isomerase
- Bifunctional protein HldE
- Lipopolysaccharide heptosyltransferase 2
- DnaA initiator-associating protein DiaA
- ADP-L-glycero-D-manno-heptose-6-epimerase
- Lipopolysaccharide heptosyltransferase 1
- UDP-glucose 4-epimerase
- Lipopolysaccharide heptosyltransferase 3
- Lipopolysaccharide glucosyltransferase WaaG
Sequence:
MAKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMDWSLADRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSARDYLHIDMAASYMVGDKLEDMQAAVAANVGTKVLVRTGKPITPEAENAADWVLNSLADLPQAIKKQQKPAQ
Protein: Apyrase GS52 (Q9FVC2)
Organism: Glycine soja (Wild soybean)
Interaction partners:
Sequence:
MVLVLWSRGTKNMDFLTLFTLLLLLFIHTALSSTQYHDGNILLTHRKIFPKQEAITSYAVIFDAGSTGSRVHVFHFDQNLDLLRIGNELEFYDKVTPGLSAYADNPQQAAESLIPLLEEAESVVPEDLYPTTPVKLGATAGLRLLEGDASERILQAVRDLLKNRSTLNAQPDAVAIIDGTQEGSYLWVTINYLLGKLGKRFSKTVGVVDLGGGSVQMAYAISRNTAKNAPKPPDGEEPYIKKLVLKGKEYDLYVHSYLHYGREASRAEILKVTDGSANPCILAGYDGTYTYSGADYKAFAPISGSSYDECREVVLQALKLNESCPHQNCTFGGIWDGGRGSGQKILFGTSSFYYLPTEIGIIDLNKPNSKIHPVDLEIEAKRACETKLEDAKSTYPNPAEDRLPYVCLDIAYQYALYTDGFSLDPWQEITVANEIEYQDALVEAAWPLGTAIEAISSLPKFDRLMYFI
Protein: Zinc finger MYND domain-containing protein 11 (Q8R5C8)
Organism: Mus musculus (Mouse)
Function: Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (By similarity). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q15326}. Chromosome {ECO:0000250|UniProtKB:Q15326}. Note=Associates with chromatin and mitotic chromosomes. {ECO:0000250|UniProtKB:Q15326}.
Interaction partners:
- Histone H3.3
- Histone H3.2
- Histone H3.1
- Histone-lysine N-methyltransferase SETD2
- La-related protein 4B
- Dip2c protein
Sequence:
MARLTKRRQADTKAIQHLWAAIEIIRNQKQIANIDRITKYMSRVHGMHPKETTRQLSLAVKDGLIVETLTVGCKGSKAGIEQEGYWLPGDEIDWETETHDWYCFECHLPGEVLICDLCFRVYHSKCLSDEFRLRDSSSHWQCPVCRSIKKKHSNKQEMGTYLRFIVSRMKERAIDLNKKGKDSKHPMYRRLVHSAVDVPTIQEKVNEGKYRSYEEFKADAQLLLHNTVIFYGADSEQADIARMLYKDTCHELDELQLCKNCFYLSNARPDNWFCYPCIPNHELVWAKMKGFGFWPAKVMQKEDNQVDVRFFGHHHQRAWIPSENIQDITVNVHRLHVKRSMGWKKACDELELHQRFLREGRFWKSKNEDRGEEEAESSISSTSNEQLKVTQEPRAKKGRRNQSVEPKKEEPEPETEAVSSSQEIPTMPQPIERVSVSTQTKKLSASSPRMLHRSTQTTSDGVCQSMCHDKYTKIFNDFKDRMKSDHKRETERVVREALEKLRSEMEEEKRQAVNKAVASLQGDMDRKGKQLKEKCKEEFVEEIKKLAAQHKQLISQTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQEHWHAEHKRTCRRKR
Protein: Armadillo repeat containing 4 (Outer dynein arm-docking complex subunit 2 isoform X1) (E7FB07)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Coiled-coil domain containing 151
- Coiled-coil domain-containing 114.
- Outer dynein arm-docking complex subunit 4
- Calaxin
- Dynein, axonemal, heavy chain 5.
- Zinc finger MYND domain-containing protein 10
- Coiled-coil domain-containing protein 39
- Dynein regulatory complex subunit 2
- Dynein axonemal assembly factor 11
- IQ motif and ubiquitin domain-containing
Sequence:
MGVTLSRAIQWSSDGNKLENSLLNNDILTEIMLFTEYFSESHPEEARLTFSEPLQWKTSLEVSDFTSEIYDVREGSVMSQERDDNRRPLLLLNPPDITVHSFYHLSNILQLNKNKNRKEVQACLEANKEVLKKIFGPNTPSINEDHLFNILCQLDEKLLDIAVKPINREGRLSPAAVNTEVDLLKTFCGTGEMRLLKSVRYTSDYVFSNGCRSPPWRQMDGEICSLIIETCDTEPTLFITCNTNGVFLDEGLKRRGGGGEKSYNAVESYNSPVINEVFKDLVTLLKNKSSHFAEVADEEGFAIQDVPSAKKILHVESVDAEKTGQTLKPYNSEEKNVLKKARQQPVQNKLGNRKKKLEPSLKWKNLGLTSPYDEGEVKARKIRESKKIFEYGTKSPTSESKKKTNISGSSLPGLQSSQKIKTPGGAEDFSESSSEEEEDEEQHERRAETATDLPSEYWQIQKLVKYLKGANQTATVIVLCSLRDFNLVQDTCQLAIRDVGGLEVLINLLDTDEIRCKIGSLKILKEISCNSQIRRTIANLGGLQTMVSILDSPDKELKCLAAETIANVAKFRRARRMVRQHGGIQRLVELLDCVPAGESLSLEQQRDVEVARCGALALWSCSKSTWNKEAIRRAGGIPMLGRLLKSPQKNMLIPVVGTLQECASEKSYRIAIQAEGMIEDLVKNLSCDNQELQMHCASAIFKCAEDKHTRDLVRQYDGLKPLVTLLNEAENKQLLAATTGAIWKCSISMENVAKFQEYKVVEILVRLLTNQPEEVLVNVVGALGECGQISENLATIRRSSGIQPLVNLLTGTNQALLVNVTKAVGACATDPENMMIIDRLDGVRLLWSLLKNPNPEVQASAAWAICPCIENAKDAGEMVRSFVGGLELIVNLLKSQNKDVLASVCAAIAKIAKDVENLAVITDHGVVPMLASLTNTEEDKLRRYLAEAIACCCTWGSNCVSFGEAGAVAPLVRYLYSKDPSVHQATARALFELSKDPNNCITMHENGVVKLLLVMIGSTDEILQEAAASCVANIRRLALANDKAKYG
Protein: LIM domain binding 1 (F2Z5G6)
Organism: Sus scrofa (Pig)
Interaction partners:
- Rhombotin-2
- TAL bHLH transcription factor 1, erythroid differentiation factor
- Erythroid transcription factor
- LIM homeobox 2
- LIM domain only 1.
- GATA binding protein 2.
- Transcription factor E2-alpha
- Insulin gene enhancer protein ISL-1
- Single stranded DNA binding protein 3
- LIM/homeobox protein Lhx3
Sequence:
MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ
Protein: Uncharacterized protein YDL009C (Q12210)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative uncharacterized protein YDL057W
- Monothiol glutaredoxin-6
Sequence:
MKALSVLCFHNPFKRCLGQKSFFVGDSFFIPTPKRLVLGKLRLSNYTAFHDLIIHDLFIYIFILNFFFFPFCNNFNYWKVFHVAQPRIYHHSRLVMILKVSLECAVS