wanglab/gogpt-training-data huggingface dataset:
Protein: 12-alpha,13-alpha-dihydroxyfumitremorgin C prenyltransferase (EC 2.5.1.110) (Fumitremorgin biosynthesis protein H) (B9WZX7)
Organism: Aspergillus fumigatus (Neosartorya fumigata)
Function: 12-alpha,13-alpha-dihydroxyfumitremorgin C prenyltransferase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities. The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA. Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B. The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively. The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable). FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B. Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties. In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
Interaction partners:
Sequence:
MTIPTEISCPEEDAFQLLDKFSWFPSDDQRRWWEYTGPYLLKLLRDAKYPQKDQVPCLYLLQQLLVPYLGTFPVVGQAPLPWWSNVTTYGVPFELSWNLLHNIVRIGFEPLSHLAESGVDAFNKTAPEECVSRLACLDNTIDLARFRHFQHHLLVTPEEETWLLREKAPLPKSGRGQQTLAVEFQNGGISAKAYFFPGMKSLATGLSPGKLILDSIERLALPGLKEPVHHLRSTLGLQDDGHPTDTAIAPFLLGVDLCTPERSRLKFYVTDQVVSWDRVADMWTLRGKRLEDPQCADGLALLRKLWDLLAIPEGYRSNIRPDFAFGTPPPEDYRPVMMANWTLSPKKKFPDPQIYLLTVGMNDAVVMDALVAFYEVLGWTDLASTYKDKVASYFPGPDFTKTNYIHSGVSFSYRHSKPYLSVYYSPF
Protein: Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) (Q96K83)
Organism: Homo sapiens (Human)
Function: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Zinc finger protein 219
- Methyl-CpG-binding domain protein 3-like 1
- Metastasis-associated protein MTA1
- Histone deacetylase 3
- Transcription factor COE1
- Histone-binding protein RBBP7
- Runt-related transcription factor 2
- Histone deacetylase 1
Sequence:
MSRRKQAKPRSLKDPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCDSCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHSS
Protein: MKIAA1400 protein (Q80TE2)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
NEAKGIKILIQPQEPPPHAAHFYLYFLDYYYSFCGGGWGAVIGVAGWLQGSCFLFLLEMIVLLFFALLWMVDGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARRFQTVANSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFRVEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGGGEGGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAKLTYSILECQIQGMSVFTYVSINSDNGYLYALRSFDYEQIKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRLDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVDGAVEPQGGGGDRGGGSGEHLRPSRSGGGETSLDLTLILIIALGSVSFIFLLAMIVLAVRCQKEKKLNIYTCLASDCCLCCCCCGNGSSTCCGRQARARKKKLSKSDIMLVQSANVPSNPAQVPVEESGGFGSHHHNQNYCYQVCLTPESAKTDLMFLKPCSPSRSTDAEHNPCGAIVTGYSDQQPDIISNGSILSNENKHQRAELSYLVDRPRRVNSSAFQEADIVSSKDSGHGDSEQGDSDHDVTNRGQSAGMDLFSNCTEECKALGHSDRCWMPSFVPSDGRQAADYRSNLHVPGMDSVPDTEVFEPPEVQPGAERSFSTFGKEKALHGTLERKELDGLLSNTRAPYKPPYLTRKRIC
Protein: Cilia- and flagella-associated protein 43 (Q580P9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Flagellar protein involved in flagellum axoneme organization and function.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:29449551}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:29449551}. Note=Closely associated to the axoneme along the paraflagellar rod. {ECO:0000269|PubMed:29449551}.
Interaction partners:
- Cilia- and flagella-associated protein 44
Sequence:
MATNARILGFNSPSALVAAGDDFLLGAGGGIVIRRKEESSQWIPCEGRYAIGALAFSPSAGLLCVTEVKLDVSLHVFRFPERHHLQCIDNVATVDVQHMLFSSDGEMLALLTCIPTTCVTFYSAARGNRLVKCASTELGGVFCKHLTFPLHRHDCIAVLEPHGVRIACNMDSATFVPSILTLSSKGHYFHSCVWGTEGLYCGAGRGQVVLLDELRTDMKNYINCETPHNVTALLQNGTLLFIGTECGDVFTYNIDQKAQRLLVRLGRSVVRLLTLPDVNDVLVATSTDVTKISVDTAQSVFVRRRSASDTVKLLVLGGLVVIVCLDGSLVTYDQDTNTAGHTPVRFPEKVVDACVVGSVAVVVYDSGFVRSFTVENTVSVVSQMKVSDCPLTACTSDGVSLLAVCDKNVVHFIEVADGLLETAASSDIFACAVTNLRWAVNGGRSVLAACNNGEVHNLRFTGKCDSASAGVTVDMTWRLDFPVNDFLPLYGDGDVINIFVHSVDKDTKMYALERQRVKESKPLRPYFLMRDHECGGNVLQRLGGDSIISAGGDGRVVVRDISHYLMKLPPVPPTKEKKHPLKEFLLRPFGRGGITCLSVWNAAGGFVCGGNDSVVHLVPVGKSPIHYSWSEPFWHQRAISTSPSRASSPSDAETLSAERSRCRIISALADLRMEVEKLLQERTPTVRAEDFLLPEQRQAFNEECEMEIHKAREDDYYSLVHNEFVQHTIKTECWDVMEVQRSKIVSMTDPETEVHNFHLRKPCAQRAKIQKKIKLMRAIQIKTEECFTLSSLVKRAKEGNLCTEQQVCGPPSDVDELLYDTLDVYTGPRATIQLILLECKILHEKKSFNIRFDTLRERKSRELNLIAERNGRCVRIMQQLGEHTCPPNVLFTPVFDIEEDPQTVFEVFDSEIDPELLKLAVKSDDGELVVSPSDEAALKTWMDGLEKVTEVLRVNVPIPPFADNSLEQYVPPEERSDEQQRIFEEYEKEVAEQTVLINEKKELLRGEVAALVKANMTSAKAIDDEIDVLRTDRMLVAQLVDELELHQVNALCLFLLKKTIRNKFLGVKREEEDLLCRLRQLDSLYEYRLKLYLASEARVQDCIEEEKNMITDMRCLPPFTDPDWGERLNRRFTTWRSKYEDGLAKVPEPTRSGVVPIPLWEQYCQCCRAVVEARDKIIHLRGEADALNDEVVEVETEKKKAQFALDDKEKAEEACRKEVIEKVLDIQNLYTLQQGQVQDENAMVSDDFTDFSIRWVKNITDYNDLIFASFDEIRSLMSRSSQLRQSMKTCSWETERLLYCIGTLEMELRQLHTLRVTRQMQETIHTGAVTSLEREINKMDARIEAVRSVMSKKVEERNRVISKLKMQINDRRAENQYLNNQVQALTNSVEDKKAVWGMLGEHNNDKDRLRERMRELYENSELEELARCQQEELVRLKNEVDRLREATFPSFAVVTRRTAR
Protein: Mitochondrial translational initiation factor 2 (H7C213)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XPIILAVNKCDKAEADPEKVKKELLAYDVVCEDYGGDVQAVPVSALTGDNLMALAEATVALAEMLELKADPNGPVEGTVIESFTDKGRGLVTTAIIQRGTLRKGSVLVAGKCWAKPRAREVVDWRKYEQEQEKGQEDLKIIEEKRKEHKEAHQKAREKYGHLLWKKRSILRFLERKEQIPLKPKEKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDASHECELELVHFGVGDVSANDVNLAETFDGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIYRLVEDLQEELSSRLPCAVEEHPV
Protein: Plant Late Embryo Abundant (LEA) related (H2FLL1)
Organism: Caenorhabditis elegans
Interaction partners:
- Bifunctional glyoxylate cycle protein
- Alpha,alpha-trehalose-phosphate synthase 2
- Trehalose-phosphatase
- Alpha,alpha-trehalose-phosphate synthase 1
- THaumatiN family
Sequence:
MSRSPSPPTITLQQDEMSESADHLLDELSKKLVDEVIPVAQGQVGNQHFDEPKSQKTPPSSLNDSYAEELLEAKLINTDESSNTTHNKMSFMDKVKDTANSAYESVENTAVGAKDGVVGAFNTVGEKIGGAYDSTKQYASDKVSAAGDYASEAGKKVGDAEDSMIQGAYDAKDSAKESASNAGNKISNAFTSLKDSITGDNAHKTGEALNDNYESVKESASEAADRLKEPAQNTADNAKDLANQTGEEMSDAFESVKQLTSDTAENAKENAHDAADTAKSYKDKAGEKASGILDSFKAHASDAKDSVENKASDAYNSAKDKAGDAWDSTKDAAGDAKDKTKSFTEKVGDKISGAYDSVKEKASDVADSFKAHSTDSKDNVENKAADAYNTAKDKASDAWDKTKDKAGEAKDKMGDAWDTTKDKAGDAWDTTKDKAGDGKGKAGDAWDTTKDKASDAWDTTKDKAGEAKDKMGEAWDHTKDKAGEAKDKASDAADDAQGKSKSMTEKIGDSISGAWESTKDTAVSAKDKTAEAAGKVGDSISGAYDTVKEKASDIADSFKAHSTDSKDNVENKAADAYNSAKDKASDAWDKTKDKAGDAKDKAADAWDTTKDKAGDAWDSTKDHAADAKDKASDAAGDAKDKSKSLTEKAGDAISGAYDSVKEKASDIADSFKAHSTNSKDNVENKASDAYNSAKDKASDAWDKTKDKAGEAKDKAGDAWDNTKDKAGNAWDSTKDKASDAWDTTKDKASDAKESAGDAADSAKDKSKSITETIGDKISGAYDSVKEKASDVADSFKAHSSDAQDTVESSASDTLESAKHHASDAADAAQDAFDSVKEKTTDMWDSAKHQTSDAGDSAEKHFDDAVDAAKDAYDSAKDKTSDTLDSVKKEGQEASDSTKSLTSDAGDAILGAYDAAKEKASDAWESTKEMVSEAYEQAEKHADDGADSAKDYVEDAKDKASDVWDSAKDKTSDVFDSLKEHGEDASDSAKDLANDAEDAIKDTYDSAKEKASDAFDSAKEHGEDAQESAKEYFEQAKEKASDALDSAQKHGDDAKESAQGYFEQAKDKSSEIWDSAKKHGEEASDSAKDYFEQAKDKASDAVESAKKQGEETSDAAKEHADHAKGKIADAWDATKDKADDVKDTAGETFENIHHSATTAVDEARENAAAAKDNASESAESTKYSIVDTAKGIAHSAEEKLEGAASVVGDAVQYVNDSATSAVSTVADSVSSAVHTVGEKLHDAEEAASNYMHGAHKSASEAAHDTKEAVTSKAAEVENVVKSSLGQRAAALHEKKREFFYSTPEKTSTVPVFVEDLNEQTLDDVPDKVEDIVAEVEKSAADAAKNTADEAKKTAEHVEQKVDENLKTGTLPSPKSGNTDTLRSTRSEGTPNKRRCTIL
Protein: Pyruvate, phosphate dikinase regulatory protein 1, chloroplastic (EC 2.7.11.32) (EC 2.7.4.27) (Bifunctional dikinase regulatory protein 1) (AtRP1) (BFRP1) (Pyruvate, Pi dikinase regulatory protein 1) (PPDK RP1) (PPDK regulatory protein 1) (O49562)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional serine/threonine kinase and phosphorylase involved in the dark/light-mediated regulation of PPDK by catalyzing its phosphorylation/dephosphorylation. Dark/light-induced changes in stromal concentrations of the competing ADP and Pi substrates govern the direction of the reaction. In the dark, phosphorylates the catalytic intermediate of PPDK (PPDK-HisP), inactivating it. Light exposure induces the phosphorolysis reaction that reactivates PPDK. Unlike the kinase function which can utilize either Thr or Ser as target, the phosphorylase function has a strict substrate requirement for threonyl phosphate.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:17996018}.
Interaction partners:
- Pyruvate, phosphate dikinase 1, chloroplastic
- non-specific serine/threonine protein kinase
- Malate dehydrogenase, chloroplastic
- Probable serine/threonine-protein kinase At1g01540
- Phosphoenolpyruvate carboxylase kinase 1
- Sodium/proton antiporter 2
- Sodium/pyruvate cotransporter BASS2, chloroplastic
- Nucleotide-sugar transporter family protein
- Probable sodium/metabolite cotransporter BASS4, chloroplastic
- Sodium/proton antiporter 1
Sequence:
MALLSAMKLQGRPPPISSNLNPNSKPAGSDSVSLNASEPGSERKPRKFSSQLNRWNRARTLRSGAKLDSTITNGSNNTTGPMRPIESSSRTDVSTLDSDVSSSSNGVSEADMTAAKSIYIVSDGTGWTAEHAVNAALGQFDYCLVDRGCPVNTHLFSGIEDGEKLMEIIKQAAREGAMVIYTLADPSMAEATMRACKLWKIPSLDILGPITESISSHLGTNPSGLSRGITNSSLNEDYFKRIEAIEFTIKHDDGALPENLEKADIVLVGVSRTGKTPLSTYLAQKGYKVSNVPIVNGVDLPKTLFEIDPRKVFGLMINPLVLQGIREARAKSLGLGSSFKTKYSELGSVKEELELAKKIFAENPTWPVIEVTESAIEETAAVVLRLYDERQSNRAMPRISKSY
Protein: Coiled-coil domain-containing protein 7 (Protein BIOT2) (Q96M83)
Organism: Homo sapiens (Human)
Function: May play a role in tumorigenesis.
Interaction partners:
Sequence:
MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGESILRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQITAQSGRLIEKSSEKKRSSPAISDLSQILKSQDESAFLESSNEVSVAENQSYKSPSETHDKSLTTVSSSKEVQDSLSVGTLAQKNETVISPFILPPVLTESKKADVSEEQLQKMTEEQTYQAAEKSQADSEVPDENLMVENKDSVTKVQIEQMKQRTSSMERHEETLTTPQLPEDMVLVSRIQSETKNLKATRNESFHSHNDVPEENLMLEQDTKSKTEVEVKKQKSFQDNQLSTHNEVPNERLVVEHQESLSKTKLQIKKQETSTEQPLTTPDKEPNENLILRHQDSMSKSEMQVKEQRTLKGQRIITHDEEPGKNLVLEHQDSVSKLEMQIEKTKKLPREKRHSTHDEESGENPMLKHQDSVSKIQVQLEIQETSEGEGRSIPDKNSMFVHQDSVSKLQMQEKKKITPGRERRNTRIVVPNENVISVHQDSKSKLQMQEKKQINSGVERHKTFPLEIKKKDISLEHLLPEEKVLLSRSESQTKKLQAKVTSRKIKNEAASELPDTAENLPAMYPSISDLIIQFDLNKVVETDIESLRGALGRRLLNDEFKTQSKSFPGPDIEQLTDAFGRDILKDEFKTRSKSLPETDERLHSTTERGTINDAIKTQLKRKSYPETVLKHLKGVNGKDIIKHLINIQSKSHGETDKEHLADDTGRGIIKGSINAQLKGHQKTDKNFFAYATGRGLMKESTTTQLKSHPETDKEFLADAIGRGIIIGPITTQLKSHRETDKELLKDAIGRDIIKGPISAQLKSHQETDVEPLTNAIGSSKTIGEIKTQLRTHYDVNLFKNKDMSVQRQEGIFTRSITPSKFPTKVINLSPFENKEETYEYSSPYVTAPSKAIYRTYRAGPSFSKDIHLPLLNQLPSGHSKVVTLSQKTIEFTLPTVTNTVGKPTYKVLHAAARKSVPHPYF
Protein: Distracted, isoform B (Distracted, isoform C) (Q9VB20)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- RING-type E3 ubiquitin transferase
Sequence:
MCLAAEPPQKQPNRSSTSPTFNAKYRRKCLLLLTLLLFHGCFSGLHRAAAFNCTAHGGRCQNDGQCQEDGQCLCADGWQGPECQFCGGKVRMYHPMGTIHDGWGNYSVSVKCSWLIDARHPHWNRRHNTNPSRTANIRIHLREFATECGWDHLYIYDGDSVDSPLLAVFSGLMYRGNFSIRRVPQVIATSGTALVHFFSDDAYNMSGFNLTYKMNSCPSDSDEVECSGHGKCRDGDCICDPMYRGEACNIAACPNNCFESKNQGHCRLDQERCSCYEGFAGDDCSQISAHGAWSTVHPKHSPAPAGSASHGATIWRDTLHIVGGESYGRGKLMSTYDFNGNVWETVHPEDGSEVPDKRYGASTVMYGDKIFMYGGVVKGHGISNELWAFDVSARTWANISVRADPSCNATGGTTAMCGPLHVVGHTATLVPGYGDKNNYQYMVVIFGHSPNYGYLNTVQEFNFASREWRIVPTTGYVVKGGYGHSAAYDFLTEKVYVYGGIVSESESSQVLSSRLYAYEPATRVWSLLSAAPSARLLHTANFVNQGLMMVFGGNTHNDTSQSYGAKCYSQDLLVYDVYCDSWHYHPMPGHLQADLARFGHSSVVFEESLYIYGGFNGQLLNDMLRYQPGYCSYYTKQEKCTAARPGVKCIWDVQKMRCIAITQVQRSAIYGREQYDYVACPSKSRLTLTSELLHDVHRCQELASCQSCVSTAFGCTYCGNGVCSKERCRETTSMASVFFESSTQMAVSTASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLACRWDSEHNRCKSYTSYGGLALNRTQDEVACSPSCASLTNCQNCTEDECIWCQNEQRCVDRNAYTASFPYGQCREWTTFTAKCRSAPIQSTALAVGSTTALSSAQCGYYNSCQMCLDDPACGWCDNGSNTGLGRCVVGGALAPYDDTECALKHWFFTSCPRCNCNGHSYCNDQQHCEQPCNNLTTGAHCEKCRTGYWGNPINGGKCQRCDCNGQGVYCHPDTGKCFCTTKGIVGDHCEKCDSQNHYHGDPLKGSCYYELTIDYQFTFNLSKKEDRHFTQINFRNSPGKPEIDADFTITCSVPAKMDISVKRAGSPDMLILVGVNCSTFRHRFPKTDYQFGHSPDDNSSLTTFYVFVHDFQPPIWIQIAFSQYPKLNLQQFFITFSSCFLLLLLMAAVLWKIKQKYDMFRRRQRLFVEMEQMASRPFSQVLVDIENRESIDLSLTLEGIGHLSKKRKKECPSPIALEPCSGNRAAVLSLLVRLPTGGLSQAPSGQSAGLAVASALVTLGNPRRPSIDQHPKEPKSKRKQSQHPDSCT
Protein: Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1 (EC 2.7.1.49) (EC 2.7.4.7) (Hydroxymethylpyrimidine kinase 1) (HMP kinase 1) (Hydroxymethylpyrimidine phosphate kinase 1) (HMP-P kinase 1) (HMP-phosphate kinase 1) (HMPP kinase 1) (O94265)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable thiamine biosynthetic bifunctional enzyme
- Thiamine-repressible acid phosphatase pho4
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c
- Acid phosphatase
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2
- Probable acid phosphatase SPBC4.06
- Alkaline phosphatase
- Low molecular weight phosphotyrosine protein phosphatase
- Thiamine-repressible acid phosphatase SPBC21H7.03c
Sequence:
MISTCITVAGSDCSGGAGVQADLKVFTAHSVYGMSAVTAITSQNTIGVNGVHLIPASYVEQQISACLLDVHCEVMKTGMLFNQQILKVIVESIDRFKIKKVVVDPLIATRKGALLVMPDYLELFVKELIPRAEVLIPNIAEALIILKHMTNEFVEIHHLEDVKAVGKKLIKAGCKNVVIRCDDIPFASDFFCSRETNMPPTWYLYVLCTSEGEVLLPQKWLASKTARGTSCALSSAVASNLAIGLDLVTATQNAVSYTQRALEMSFHLGRGANSLDYASALTRLPYEKGEFINFVRYHPSITPKWLSIVNHPFVEQLKAGTLSRLPFQKYLVLKYHMLINNAQAAGMMAFSSSSISAIEHSAKIIQAIKEENVTHLRICEQYGLSASQITKSKPEIVKSHSLFIHDTAQQDGLRGIQIAMLPFVFMIQEVVSQISASDGYPYVAWVEHCKDKSATSHIETLLESLETNSQIISLSKVQHLLGILEKSLDFERLVLDTSSSNESSVF
Protein: Aftiphilin, isoform B (Aftiphilin, isoform C) (Aftiphilin, isoform D) (RE49017p) (Q9VFK5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVNVPPLLCSTPPPIDFGEEDDDSGLQSTIHLDEGDEYSDFGLVSSSKEPPPPPDPVEEFREKPPDLLEDKQTVEAFNYQVKQKMDYDVFEETAPPTPPPLSLELDDEELEEHVPSLKLDSLSLYSTESVSAASTLSPVAETSAVAPPAMQTTKAHILSHQVTLEDVSDDSDEECSPKKPKELFIREGAVDFFAIEVLATPTLPYGEGFSEENVDTGKGEYVENTSQPEESFRSLEAQEESSNTLEKPMENQSRGLSNPPNQEESPHQWGEPANSDTYSFTNLDATPKDLVHKEIVPEMQEQEDDDDFGDFADFSAAEPQLEITENSTSAFETPSLAINSRTESQPLEVKTAPSTEESSKLPPAETDDGFDDFQEFATPANGNHGQSEDDDDFGDFAAPVVTPVSVPPPPPPAAVHLSIDERVKPVLDMMFPQPTELDSKSMDNRRPLAQCQRFNFGAIEHAQALDYQWSSSEMRHALVRSLGIDSRNILFGDKWNSSMPRFAANLSFDPLKPLKPQSTGAASSLEPISNSTSYQGLENAAATTASQTETRTGPSHGEGSTGSCSASNSDGEERPSHSHQPTAVPSPESNHIESTAAASAAAVAAAAATLPTTLSADSPAHKLNGGEQLHQQRSEPEQFDLRTTPPAAAPAQEEIVGSSMASYSVPLKETHIYTPSKSDTAVAKTTTLAPIDFDYEMAATGIIIDETVVKKEYRDVEYKPPFGLDSPSKLSGNGAASSFQLPPQTTEDDDFSDFQSMPAPRSRIDTPTFGEQMILSPAILLPQAIPLAKKPAATIEWGDNALSSINAEEMARIEELFSSQAKPLTISASVAKKPAPSTPAQSQPQEDDEWSDFVSVPVTQQQPHHQQNAIANNNNIVNSNARKPAAPKEDDWSDFVSSTPPARPAPQFNSGAWQSANFYNNPLSLYQAQQQLQQQPHSNLVPKGSTSSSNNNNVPAIPQQIHIMHDFSTAPVSGGLGVGATYQQQHQRQQFQIGNAKVAPRISLIPDLSFVAPALPTNAGAFMGALPKPTFGGKK
Protein: Leucine-rich repeat (LRR) family protein (F4JNB0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein
- At3g05070
- Probable disease resistance protein At5g43740
- Phosphatidylinositol 4-kinase gamma 3
- PR5-like receptor kinase
Sequence:
MEDSDLEKLWNGTQLLGSLKKMILRNSKYLKEIPDLSLATNLERLDLCKCEVLESFPTPLNSESLEYLNLLRCPKLRNFPEIIMHSFRGEIDIEVADCLWNKNLPGLGYLDCLRRCNPSKFRPEHLKDLTVRCNNKLEKLWEGVQVIHTYIIY
Protein: CG11156 (Q2XXV4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
DETICAYFVNNLKPGDGGVQEADTLQQFDAARELLGQQLAETQIRQIKPSEGYPLIAAGNLTKKDVFVLTQFEGEFFEQLQQTRALILGPPCLITCLRRNEPIPEGSSAIYSTAMRDLQVSATGITPQKKEELSRLINWMGGIYFQSFGHRTTHLISNTIKSSKYEQATLNGVPVMHVDWVQYVWDQSRRSQREGIMATDPDFDKYRLPIFFGANITCSGLDVARKDQVMRLVNDNGGIYHRAFRSQVVDIVITEQTKTDTEKYKAAIRYKKDVLLPEWIFDSCNRGYALPTKDYEVRPGKTSSTPTKTTRPGAAPGADQTHLSDLSRISFVSGSRRMCSDLSTVNESVSSVGSISPAKQLLKQATNSGRNYQQVLAEIEPRQAKKAGAFLDGCCVYLSGFRSEEREKLNRVLNTGGATRYDEANEGISHIIVGQLDDAEYRQWQRDGLMGSVHVVRLDWLLESIRAGRVVSELVHRVSMPQNREPDVASPASKRTLRSMNHSFKQPTLPIKKKLFDQEPDPVQEQEHEEPDHTLLDQYSQDQGAVAQLPPADVSLLQPAASSTQMDIRQRVSVANPKPPADGLQLPDLSASTLSIDFDKLDYFAGVSVYVHRECFNEEFFNQMLTECEAAQGLLVPSSFSDEVDFAIVSFEVAFDVKQLPVKARHVVTELFLESCMKKNQLLPIEYYHKHVPATALRQPLKGMTIVVSIYAGLERDFINATAELLGASVNKTFIKKEKPLLVCPSAEGSKYEGAIKWNYPVVTSDWLVQCARTGQKLPFVGYLVGKSPEDFPISPRLRESNSRIARKPNESTLVAQPDVTMEEAENQPAGSVTPVTAGSPGAPELTPLRNKRVSELAGIPGGSARHRGSNSTSSPDSPCTPLSQVGAQQYNLDFLEQFVQRLDTEEGKDCVREIIREMRENQTPELERIRRQACTPVSRKHQRPAPGIPDFCLTPEFQQRMADDFERRWRLPTMKIKPDTPLAVIRQRVMRITCETLGIEYEESNAKTPTLSESPSTVKKKPPTRTTQATKLNFDRSPKTPKLSLGKKTPLRVSMGSPRSGTQSPFVPNTQSPIEAAPPRRSDGPTLSEEGQSTINFDKISFEESAVPVMAPDVPTVAPDVKQITDYLKNCESRRNSLKRSHDNDMDCGESEVQYVQPFESEGFALGTEDMVDWRDPAEFNAAKRRSSGGSPKMQYAGIPCFSISCGDDDEKRAELIARITQLGGKVCENLVNYDDSCTHLLCERPNRGEKMLACIAAGKWILNIQYIEQSHARGDFLDETLYEWGNPKAINLPTLAPEEEPIAAAVHRWRTELSACGGGAFSDHRVILSMNERSGAPIRNVLRAGGACILEPTTPFSKDPVAKSASHCFVDVKKAPLSTQDMEYLHKCGVQVLSQIAINAYLMNGRDADL
Protein: 5-hydroxytryptamine receptor 5B (5-HT-5B) (5-HT5B) (MR22) (Serotonin receptor 5B) (P35365)
Organism: Rattus norvegicus (Rat)
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P47898}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- 5-hydroxytryptamine receptor 5A
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MEVSNLSGATPGIAFPPGPESCSDSPSSGRSMGSTPGGLILSGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASALMIAITWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYVPLAVVLFVYWKIYKAAKFRFGRRRRAVVPLPATTQAKEAPQESETVFTARCRATVAFQTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELVSPLCACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR
Protein: UDP-2,3-diacylglucosamine pyrophosphatase LpxI (A0A0H3C8Q1)
Organism: Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Interaction partners:
Sequence:
MRKLGLIAGGGALPVELASHCEAAGRAFAVMRLRSFADPSLDRYPGADVGIGEFGKIFKALRAEGCDVVCFAGNVSRPDFSALMPDARGLKVLPSLIVAARKGDDALLRRVLDEFEKEGFEIEGAHEVMGEMTLPRGRLGKVSPAPEHMADIDKALDVAREIGRLDIGQGAVVCEGLVLAVEAQEGTDAMLRRVADLPEAIRGRAERRLGVLAKAPKPIQETRVDLPTIGVATIHRAARAGLAGIVGEAGRLLVVDREAVIAAADDLGLFVLGVDPQERP
Protein: Symplekin (Q7ZYV9)
Organism: Xenopus laevis (African clawed frog)
Function: Involved in histone mRNA 3'-end processing (By similarity). Involved in the cytoplasmic polyadenylation element (CPE)-mediated polyadenylation of maternal mRNAs in maturing oocytes. Serves as a scaffold upon which cytoplasmic polyadenylation regulatory factors are assembled.
Subcellular location: Nucleus {ECO:0000269|PubMed:12006661}. Cytoplasm {ECO:0000269|PubMed:12006661}. Note=Cajal bodies (CBs).
Interaction partners:
Sequence:
MAVSMASQFFSQEEGTSEVVSTSERVVELLNMAALATNDTKITMLKQVQELIINKDPTLLDNFLDEIIAFQADKSVEVRKIVVNFIEEACKLDNELLIKLIANLHMLLKDENVNVVKKSILTMTQLYKVALQWVARSRPPSEQQESCWDLVTEMAADILLLLESDNDGMRTHAVKFVESLIVTLSPRTADSEVPKRQDGDISLEQIPPDHQFLKYNTLRDLGKQAVKELLKFMAHPAISSINLTAALGSLASIARQRPMFMAEVIQAYETLHANLPPTLAKSQVSSVRKNLKLQLLSVLRHPSSYEYQGPISTLLLDLGTSQGEITRHLPPPRDSNRKRAREDGEGGQKKSRTDIPLPDDDDDKDTMQLPTIPAPAPSTQSATDITADFVRPLLSPENVANLVLISMVYLPDSMPASFQSTYTPVESAGTDSQIRHLARLMATQMSAAGIGPGVEQSKDIPVDVVEEENIKPEGLVIKRRISALTKGQAISVLGCQSEKTKEEEEEEDDAPLAKKRPEPILPATQIRPSGVGGRKKVFRLKEVTEPLTDVQIKSLKLGAVRRILQAERSVGSSGASQMRVKVLARLVTQLDISVKAEVLSHFLNDPRMRLDLALAWLYQEYCEYQSGAGEEGYQECLIGILTGLQERPDQRDGVFTKVVLEAPLLTDSALDVLRKYCEDEGRSYLGMSTLRDLILTRPARQFQYLHLLLDLSSHEKDKIRQQSLHFIKRMYEKESLRPYIEKFALNYLQLLVHPNPPSVLFGADKDTEVAAPWTEDTVKQCLYLYLALLPQNHKLIHELASVYTEATADIKRTVLRVIETPIRGMGMNSPELLLLVENCPKGAETLVTRCLHILTDKVPPSPELVKRVRELYHKRLPDVRFLIPVLNGLDKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEVSSSLSPLTPGDLLVALHNIDSSKCDMKSVIKATNLCFSARSVYTSEVLAVVLQQLMDTTPLPMLLMRTVIQALGMYPRLGGFIMNILTRLIYKQVWKYPKVWEGFIKCCQRTKPQSFSVLLQLPPPQLLSVLQTSPDLRDPLLAHVRAFTPHQLAHVPHSIMAILEAESRTDAGAEEAAQVEEEQETPAQDIIARRLAQEKSLKKQIEEQKGRNNQEMEEVAEVDPPAIFIAEEEEEESLKSQGKEEPQEDSSSNATTAEKSPVADEPMEEEPVEKKD