wanglab/gogpt-training-data huggingface dataset:
Protein: Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP) (Q02556)
Organism: Homo sapiens (Human)
Function: Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:25122610}. Cytoplasm {ECO:0000269|PubMed:25122610}. Note=In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction. {ECO:0000269|PubMed:25122610}.
Interaction partners:
- Transcription factor PU.1
- Interferon regulatory factor 1
- Signal transducer and activator of transcription 1-alpha/beta
- Interferon gamma
- Transcription factor Spi-B
- Signal transducer and activator of transcription 2
- TNF receptor-associated factor 6
- E3 ubiquitin-protein ligase TRIM21
- Basic leucine zipper transcriptional factor ATF-like 3
- Runt-related transcription factor 1
Sequence:
MCDRNGGRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKLGVATAGCVNEVTEMECGRSEIDELIKEPSVDDYMGMIKRSPSPPEACRSQLLPDWWAQQPSTGVPLVTGYTTYDAHHSAFSQMVISFYYGGKLVGQATTTCPEGCRLSLSQPGLPGTKLYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERGVLLHSSRQGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQFYNSQGRLPDGRVVLCFGEEFPDMAPLRSKLILVQIEQLYVRQLAEEAGKSCGAGSVMQAPEEPPPDQVFRMFPDICASHQRSFFRENQQITV
Protein: Zinc finger protein 133 (Zinc finger protein 150) (P52736)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation as a repressor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription intermediary factor 1-beta
Sequence:
MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETWREEKKCSPATCPADPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNGLRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL
Protein: Chorionic somatomammotropin hormone 1 (Choriomammotropin) (Lactogen) (Placental lactogen) (PL) (P0DML2)
Organism: Homo sapiens (Human)
Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.
Subcellular location: Secreted.
Interaction partners:
- Chorionic somatomammotropin hormone 2
- Growth hormone receptor
- Somatotropin
- Prolactin receptor
- Prolactin
- Erythropoietin
- Leptin
- Chorionic somatomammotropin hormone 1
- Granulocyte colony-stimulating factor
- Thrombopoietin
Sequence:
MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF
Protein: Putative acyl-CoA dehydrogenase FadE17 (EC 1.3.99.-) (P95280)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Putative enoyl-CoA hydratase EchA13
- Probable acyl-CoA dehydrogenase FadE18
- Acyl-CoA dehydrogenase IpdE2
- Probable acyl-CoA dehydrogenase FadE32
- Acyl-CoA dehydrogenase FadE27
- Mce-family protein Mce3A
- Probable fatty oxidation protein FadB
- Conserved hypothetical integral membrane protein YrbE3B
- Mce-family protein Mce3C
- Electron transfer flavoprotein subunit beta
Sequence:
MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPPHEREEFARHWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLLGIDLLGNTLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVRTRGVLDGDEWVINGHKIWTSAGTTANWIFLLARTDPSAAKHRGLSFLLVPMDQPGVVVRPIVNAAGHSSFSEVFLTDARTSAGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGLHTDPRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSEYFRRYTDLAVEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLYARAATIYAGSSQIQRNVIGERLLGLPKEPRPEVLC
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (A8JNX2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}. Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004326}.
Interaction partners:
Sequence:
MSKTPKPLTSKRRTSPASPGSTVLIESPTTSSGVRNRRSKIKGVDSKPNPQRTISHVKDSRAVPQNVKPGKVADMKDCKEPDEDNVDQTGLTLTPEMLLSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTLLGQPTEGALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKKWFERTMERKMYSTRSELDFV
Protein: HLA-A26 protein (O19633)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAVMAPRTLVLLLSGALALTQTWAGSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDRNTRNVKAHSQTDRANLGTLRGYYNQSEDGSHTIQRMYGCDVGPDGRFLRGYQQDAYDGKDYIALNEDLRSWTAADMAAQITQRKWETPPMRRSSGEPTWRAGAWSGSADTWRTGRRRCSARTPPRRI
Protein: Gamma-glutamylethanolamide synthetase GlnA4 (EC 6.3.1.-) (O88070)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Function: Involved in the catabolism of monoamine ethanolamine. Catalyzes the ATP-dependent gamma-glutamylation of ethanolamine. No activity with polyamines. No complementation of the L-glutamine auxotrophy of an E.coli glnA mutant. Enables survival of S.coelicolor under high local environmental ethanolamine conditions. May play a role during starvation conditions to limit intracellular ethanolamine concentration, which in excess is toxic to the cells.
Interaction partners:
- Glutamate synthase large subunit
- Dehydrogenase
- Glutamate dehydrogenase
- Uncharacterized protein
- Transcriptional regulator
- Gamma-glutamyl-gamma-aminobutyrate hydrolase family protein
- assimilatory sulfite reductase
- Gamma-glutamylpolyamine synthetase GlnA3
- Gamma-glutamylpolyamine synthetase GlnA2
- Glutamine synthetase
Sequence:
MSPGQKEALPVADRTPPLGVEELHALVAAGDIDTVVLAFPDMQGRLQGKRFAARFFLDEVLEHGTEGCNYLLAVDADMNTVDGYAMSSWDRGYGDFAMRADPATLRRLPWNEGTAMAVADLAWEDGSPVLAAPRQILRRQLERLAGHGYTAQVGTELEFIVFRDTYEHAWDANYRGLTPANQYNVDYSVLGTGRVEPLLRRIRNEMAGAGLTVESAKGECNPGQHEIAFRYDEALVTCDQHAVYKTGAKEIAAQEGMSLTFMAKYNELEGNSCHIHLSLADADGRNAMAEGGGMSDVMRHFLAGQLVALREFSLLYAPHINSYKRFQPGSFAPTAVAWGHDNRTCALRVVGHGRSLRFENRLPGGDVNPYLAVAGLVAAGLHGIEQRLELPEPCPGNAYTADFAHVPTTLREAAELWENSTLAKAAFGDEVVAHYRNMARVELDAFDAAVTDWELRRSFERM
Protein: Protein FANTASTIC FOUR 2 (Q8GXU9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates the size of the shoot meristem by modulating the CLV3-WUS feedback loop. Can repress WUS but is under negative control by CLV3.
Interaction partners:
- Zinc finger CCCH domain-containing protein 52
Sequence:
MSLVVCQPQINESFYQKDDMGGLSFLQSMSDITSIAQTKEDKAYVHPMEKRSVSKLNEKSLEMCTESLGTETGSESGDELSLLAFEATTTPRAPPRQLKPQEDTNLPDKTPPMSRNNSFPPPIKFVEDSKYNRMVRWLGEDGRIVVQAIRVSSPPSCFVSERGEGRLRLILTSESSLLSHNHEEEEEEETEEGIDEETSENLEGKSGNKKFSRFSRRCKENGREPKPMLTWKQQQFWVAT
Protein: Cell division cycle 34, ubiqiutin conjugating enzyme (D4A453)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- E3 ubiquitin-protein ligase RBX1
- E2 ubiquitin-conjugating enzyme
- Ubiquitin-ribosomal protein eL40 fusion protein
- Polyubiquitin-C
- S-phase kinase-associated protein 1
- Ubiquitin-like modifier-activating enzyme 1
- Cullin-1
- Ubiquitin conjugating enzyme E2 V1 like 1
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-like modifier-activating enzyme 6
Sequence:
MARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKVPTTLAEYCVKTKAPAPDEGSDLFYDDYYEDGEVEEADSCFGDEEDDSGTEES
Protein: BOS complex subunit NOMO2 (Nodal modulator 2) (pM5 protein 2) (Q5JPE7)
Organism: Homo sapiens (Human)
Function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15257293, ECO:0000269|PubMed:17261586, ECO:0000269|PubMed:36261522}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- BOS complex subunit NCLN
- BOS complex subunit TMEM147
- Xylosyltransferase 1
- Density-regulated protein
- rRNA-processing protein FCF1 homolog
- ATP-binding cassette sub-family C member 6
Sequence:
MLVGQGAGLLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGFSVCGRISIIRFPDTVKQMNKYKVVLSSQDKDKSLVTVETDAHGSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTFPLTVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKVNAMTFTFDNVLPGKYKISIMHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGRENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQEREKNGNEEGEERMTKPPVQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSMEAVVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVTSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGLFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSENLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKHITLIFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVGALGQAASDNSGPEDAKRQAKKQKTRRTLRLQEEFQLMWCLVPWRGTLGIHLFSSLPFASEILLETTATCIHY
Protein: Chemokine binding protein (Q2F862)
Organism: Orf virus (strain NZ2) (OV NZ-2)
Interaction partners:
Sequence:
MKAVLLLALLGAFTNAAPLLESQRSNSEEKANFCSTHNDEVYARFRLQMRVGVRHSPLYTPSNMCMLDIEDSVEDIEESTEKEYASTATGEAAGVNVSVALVGEGVSIPFSYIGLGFNPSLEDSYLYVNVSSRAPWVKQTSDLSANGGWGIKQVLEKELLAIQIGCDNQKFPEEPTTTPPSPVTTTLSSTTPDLNEENTENTPTTTGASVDRKRNPADIDFSLLVDPRCVTSVDLHVELRDACIDYKQESPLSLKGKYGDGELVKKEIKDVGKNHNMCSLNLNPGN
Protein: Negative regulator of flagellin synthesis (Anti-sigma-28 factor) (G3XCL4)
Organism: Pseudomonas aeruginosa
Interaction partners:
Sequence:
MVIDFNRLNPGSTPATTGRTGSTAAGRPDATGADKAGQAATSAPKSGESVQISETAQNMQKVTDQLQTLPVVDNDKVARIKQAIADGTYQVDSERVASKLLDFESQR
Protein: Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin) (Q15884)
Organism: Homo sapiens (Human)
Function: Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched in endosomes compared to the cell membrane. {ECO:0000269|PubMed:34927784}.
Interaction partners:
- Tight junction protein 2
- Translocator protein
- Transmembrane channel-like protein 1
Sequence:
MILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAALRYLQIFATRRSCIDESQISAEEAEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQMDQEQGSSFQMSEGSEAAVIPLDLGCTQVTQDGDIPNIPAEENASTSTPSSTLVRPIRSRRALPPLRTRSKSDPVLHPSEERAAPVLSCEAATQTERRLDLAAVTLRRGLRSRASRCRPRSLIDYKSYMDTKLLVARFLEQSSCTMTPDIHELVENIKSVLKSDEEHMEEAITSASFLEQIMAPLQPSTSRAHKLPSRRQPGLLHLQSCGDLHTFTPAGRPRAERRPRRVEAERPHSLIGVIRETVL
Protein: RNA polymerase II-associated protein RBA50 (RNA polymerase II-associated protein of 50 kDa) (Q04418)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14690591}.
Interaction partners:
- GPN-loop GTPase 1
- GPN-loop GTPase 2
- GPN-loop GTPase 3
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MDLLGDIVEKDTSDSVESNDNGTLSTNNCGTGFPELYKPKKISSWKERLREKRAQKKKTSGKDAEKQQTSTDAPLSEAKSIHNENIKVLQGMSDEQIVQEREDLYNSLDPKLIAKLLKNINKRAKDENNTPLFAEIEGASGTWVGGNKQGIYDLPPLDDEDVDVALEIRPMLGKDAKHVQFEEAGKEKDVEEEAKTNDDVDDIAPLDFQMAQCIDHMKNEELFKDVHFIKEESQNEINLEKLDINDPNFNDKLHEKYFPDLPKEVDKLKWMQPVQQKTDKNYIIEDVSECRFDFNGDLVPPTRQIDSTIHSGLHHHSDSPELAGYTIVELEHLARSTFPSQRCIAIQTLGRILYKLGQKSYYQLVPEIDADTYKEDGSISNVMDKIYSMFWDLIKDGKVIESLEISSDEKFTRNLSVRNYAIDALWLWKQGGGDFRTKK
Protein: Testis-specific chromodomain protein Y 2 (EC 2.3.1.48) (Q9Y6F7)
Organism: Homo sapiens (Human)
Function: May have histone acetyltransferase activity.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Testis-specific basic protein Y 2
- Deleted in azoospermia protein 1
- Testis-specific basic protein Y 1
- Histone H3-7
- Histone H3.3
- Histone H3.1t
- Histone H3.3C
- Histone H3.2
- Histone H3.1
- Deleted in azoospermia protein 2
Sequence:
MASQEFEVEAIVDKRQDKNGNTQYLVRWKGYDKQDDTWEPEQHLMNCEKCVHDFNRRQTEKQKKLTWTTTSRIFSNNARRRTSRSTKANYSKNSPKTPVTDKHHRSKNCKLFAASKNVRRKAASTLSDTKNMEIINSTIETLAPDSPFDHKKTVSGFQKLEKLDPIAADQQDTVVFKVTEGKLLRDPLSHPGAEQTGIQNKTQMHPLMSQMSGSVTASMATGSATRKGIVVLIDPLAANGTTDMHTSVPRVKGGQRNITDDSRGQPFIKKMHFTIRLTESAITYRDIVVKKEDGFTQIVLSTRSTEKNALNTEVIKEMVNALNSAAADDSKLVLFSAAGSVFCCGLDFGYFVRHLRNDRNTASLEMVDTIKNFVNTFIQFKKPIVVSVNGPAIGLGASILPLCDLVWANEKAWFQTPYTTFGQSPDGCSSITFPKMMGKASANEMLIAGRKLTAREACAKGLVSQVFLTGTFTQEVMIQIKELASYNAIVLEECKALVRCNIKLELEQANERECEVLRKIWSSAQGIESMLKYVENKIDEF
Protein: DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (Q584D9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA-
- DNA-
- Protein artemis
Sequence:
MQRVLPFALHCYFNLGSAMRDWHALAPSAAIHLPMTLCGGQCFRWRRTPRGTWVGVVRHTAYELCDPLKMSIAKPEQKKARKTASFLSPLSLAATAAPPFISSADVSATGQPSADLLWFRCLNCDLRSESDAREQTLFLRHYLALDVDLQKMWLRWTADNPMKSHPLVKCLTPCGSTDLPVSIRHLRQDLHETLLGFLCSQNNNVPRITSLMERLSISYGDYLCDYNVVTGDVRHAAHCGNVKGNPSEQNDGGGWIALHALPSMDQLAAATEESLRALGFGYRSRYLTECAAIISKSGATRVQKEVKDKKMKKKEVGKPAGPLAAVQPYKWYEELASNRLTLQERREKLLALPGVGRKVADCILLFALGHHELVPVDTHMAQVAAEYLACPPAVVVAAKKQRESEASERLKRRRGSNHEELANAVDSGDSVLSSLSWENTLVEWYRNGRGKKAKFPALLLKHHDAIQYGFKLLFGDYCGWAHSILFYARMRSSGNKEATA
Protein: Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (Lysosomal membrane glycoprotein A) (LGP-A) (CD antigen CD107a) (P49129)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity). Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis (By similarity).
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:P11279}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:P11279}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:P11279}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P11279}; Single-pass type I membrane protein {ECO:0000255}. Cytolytic granule membrane {ECO:0000250|UniProtKB:P11279}; Single-pass type I membrane protein {ECO:0000255}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (By similarity). {ECO:0000250|UniProtKB:P05300, ECO:0000250|UniProtKB:P11279}.
Interaction partners:
Sequence:
MAAPGAPRSLLLLLLAGLAHGASALFVVKDSNGTACIMANFSASFFTIYETGHGSKNSTFELPSSAEVLNSNSSCGRENVSEPILTIAFGSGYLLTLNFTRNATRYSVQDMYFAYNLSDTQHFLNASNKGIHSVDSSTDIKADINKTYRCLSAIQVHMGNVTVTLSDATIQAYLLNSNFSKEETRCTQDGPSPTTVPPSPSPPLVPTNPTVIKYNVTGENGTCLLASMALQMNITYMKKDNMTVTRALNISPNDTASGSCSPHVVTLTVESKNSILDLKFGMNGSSSLFFLQEVRLNMTLPDANVSSLMASNQSLRALQATVGNSYKCNTEEHIFVTKEFSLNVFSVQVQAFKVESDRFGSVEECMQDGNNMLIPIAVGGALAGLVLIVLIAYLIGRKRSHAGYQTI
Protein: Ethylene-responsive transcription factor WRI1 (Protein ACTIVATOR OF SPORAMIN::LUC 1) (Protein WRINKLED 1) (Q6X5Y6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Transcriptional activator involved in the activation of a subset of sugar-responsive genes and the control of carbon flow from sucrose import to oil accumulation in developing seeds. Binds to the GCC-box pathogenesis-related promoter element. Promotes sugar uptake and seed oil accumulation by glycolysis. Required for embryo development, seed germination and, indirectly, for seedling establishment. Negative regulator of the ABA-mediated germination inhibition.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic
- B3 domain-containing transcription factor FUS3
- Diacylglycerol O-acyltransferase 1
- B3 domain-containing transcription factor LEC2
- Nuclear transcription factor Y subunit B-9
- Phospholipid:diacylglycerol acyltransferase 1
- Diacylglycerol O-acyltransferase 3
- Oleoyl-acyl carrier protein thioesterase 1, chloroplastic
- B3 domain-containing transcription factor ABI3
- Delta
Sequence:
MKKRLTTSTCSSSPSSSVSSSTTTSSPIQSEAPRPKRAKRAKKSSPSGDKSHNPTSPASTRRSSIYRGVTRHRWTGRFEAHLWDKSSWNSIQNKKGKQVYLGAYDSEEAAAHTYDLAALKYWGPDTILNFPAETYTKELEEMQRVTKEEYLASLRRQSSGFSRGVSKYRGVARHHHNGRWEARIGRVFGNKYLYLGTYNTQEEAAAAYDMAAIEYRGANAVTNFDISNYIDRLKKKGVFPFPVNQANHQEGILVEAKQEVETREAKEEPREEVKQQYVEEPPQEEEEKEEEKAEQQEAEIVGYSEEAAVVNCCIDSSTIMEMDRCGDNNELAWNFCMMDTGFSPFLTDQNLANENPIEYPELFNELAFEDNIDFMFDDGKHECLNLENLDCCVVGRESPPSSSSPLSCLSTDSASSTTTTTTSVSCNYLV
Protein: Small ribosomal subunit protein eS4 (40S ribosomal protein S4, X isoform) (Q642H9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62701}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62701}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250|UniProtKB:P62701}.
Interaction partners:
- Small ribosomal subunit protein uS15
- Ribosomal protein L18
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein uL10
- 40S ribosomal protein S24
Sequence:
MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPTGFMDVVSIEKTGENFRLIYDVKGRFTVHRITNEEAKYKLCKVRKILIGTKGIPHLVTHDARTIRYPDPLIKVNDTIRIDLDTGKITDFIKFETGNMCMVTGGANLGRIGVITNREKHPGSFDVVHVKDSIGNSFATRLSNIFVIGKGNKPWVSLPRGKGVRLTIAEERDKRLAAKQSSS
Protein: MKIAA1348 protein (Q5DTY5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
PPATCFRMSSTVSYWIFNSARNRIALLRGGRRLYSRAATSRNLLKWRPFSPALASSALKCGSPPGGFALRKAYRHTSTEEEDFHLQLSPEQVSDLLRAGESSHKVLDFNNGVPNSVLRFESNQLAANSPVEDRQGVATCVQTNGMMFGIFDGHGGHACAQAVSERLFYYMAVSLMSHQTLEQMEEATENMKPLLPILRWLKHPGDSIYKDVTSVHLDHLRVYWQELLDLHMEMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGATACMAHVNGVHLHVANAGDCRAILGVQEENGAWSCLPLTCDHNAWNEAELSRLKREHPESEDRTLIIDDRLLGVLMPCRAFGDVQLKWSKELQRNVLARGFDTEALNIYQFTPPHYYTPPYLTAKPEVTYHRLRRQDKFLVLASDGLWDMLGNEDVVRLVVGHLSKVGRHKPDLDQRPANLGLMQSLLLQRKASGLHAADQNTATHLIRHAIGSNEYGEMEPERLAAMLTLPEDVARMYRDDITVMVVFFNSDSIDTYCKEG
Protein: Beta-casein (W5RWE1)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKVLILACLVALALARETIESLSSSEESITEYKQKVEKVKHEDQQQGEDEHQDKIYPSFQPQPLIYPFVEPIPYGFLPQNILPLAQPAVVLPVPQPEIMEVPKAKDTVYTKGRVMPVLKSPTIPFFDPQIPKLTDLENLHLPLPLLQPLMQQVPQPIPQTLALPPQPLWSVPQPKVLPIPQQVVPYPQRAVPVQALLLNQELLLNPTHQIYPVTQPLAPVHNPISV
Protein: Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Spacer peptide 2 (SP2) (p1); p6-gag] (P04591)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
Function: Mediates, with Gag-Pol polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi).
Subcellular location: [Gag polyprotein]: Host cell membrane; Lipid-anchor. Host endosome, host multivesicular body {ECO:0000250|UniProtKB:P12493}. Note=These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly. {ECO:0000250|UniProtKB:P12493}.; SUBCELLULAR LOCATION: [Matrix protein p17]: Virion membrane; Lipid-anchor {ECO:0000305}. Host nucleus {ECO:0000250}. Host cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Capsid protein p24]: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion {ECO:0000305}.
Interaction partners:
Sequence:
MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSNQVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPGHKARVLAEAMSQVTNSATIMMQRGNFRNQRKIVKCFNCGKEGHTARNCRAPRKKGCWKCGKEGHQMKDCTERQANFLGKIWPSYKGRPGNFLQSRPEPTAPPEESFRSGVETTTPPQKQEPIDKELYPLTSLRSLFGNDPSSQ