wanglab/gogpt-training-data huggingface dataset:
Protein: WASH complex subunit 2 (Q6PGL7)
Organism: Mus musculus (Mouse)
Function: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L.
Subcellular location: Early endosome membrane {ECO:0000250|UniProtKB:Q9Y4E1}. Cell membrane {ECO:0000250|UniProtKB:Q9Y4E1}.
Interaction partners:
- WASH complex subunit 1
- WASH complex subunit 5
- WASH complex subunit 3
- WASH complex subunit 4
- Vacuolar protein sorting-associated protein 35
- Sorting nexin-27
- TBC1 domain family member 23
- DnaJ heat shock protein family
- Coiled-coil domain-containing protein 93
- Vacuolar protein sorting-associated protein 29
Sequence:
MNRTSPDSERPPASEPVWERPWSVEEIRRSSQNWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIQETKATHCRLHNVFNDFLMLSNTQFIENRVYDEEVEEQVLKAEAEKAEQEKTREQKEIDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANERVDLILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDSEDEKEEEESDEDFASHSDNDQNQHTTQISDEEEDDDGDLFADSEKEGDDIEDIEESAKSKRPTSFADELAARIKGDISNQRKEGQTDGKPQKTVKEKKERRTPADDEEDILFPPPTLTDEDFSPFGSRGGLFSNGQGLFDDEDESDLFKEAPRARPAQAPVSEELPPSPKPGKKIPAGAVSVLLGHPDVSGSTSAPSLKELQKHGQPTPGKSSHLPTPAGLFDDDDNDNDEDDNNFFMPSSSKPSKTDKVKSTAIIFDDDEGDLFKEKAEALPAASVSQTHESKTRADKTIALPSSKNLKLVSETKTQKGLFSDEEDSEDLFSSQSSSKPKSASLPSSQPPTSVSLFGDEDEEDSLFGSAAAKKQTSSLQPQSQEKAKPSEQPSKKTSALLFSSDEEDQWNIADSHTKLASDNKSKGELWDSGATQGQEAKAVKKTNLFEDDDDDEVDLFAIAKDSQKKTQRTSLLFEDDAESGSSLFGLPPTSVPSATTKKESVPKVPLLFSDEEDSEVPSGVKPEDLKVDNARVSPEVGSADVASIAQKEGLLPASDQEAGGPSDIFSSSSPLDKGAKGRTRTVLSLFDEDEDKVEDESSTCAPQDGREKGLKTDSRPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKIRSSVPSGGSLFGDDEDDDLFSSAKTQPVVPEKKGTLKKDHPVSLKNQDPLDSTQGSKEKSTWKTEPAQDSSGLTPFKSREPSSRIGKIQANLAINPAALLPTVALQIPGTKPVSSELAFPSSEPGRSHILESVPTLPGSVEAGVSFDLPAQADTLHSANKSRVKVRGKRRPQTRAARRLAAQESSEAEDVTVDRGPVAQLSSSPVLPNGHQPLLQPRMASGQTSSETATAPPWEGGPVLSAADRSFFVKSRPQTGNEADLFDSGDIFPKSRGSQSVEGAGVMAGEPPSHSSGGRKEKSLAFPDLSEGSSTEDLFQSVKPRAAKNRNPFPLLEDEEDLFADPRGKKNERKPDSHQDSVSKTHDIFEDDIFATEAIKPFPKKREKGRTLEPNLFDDNIDIFADLTVKPKEKSKKKVAAKSMFDDDTDDIFSSGLQAKASKPKSQSAEAASEQRSEHKVASIFDDPLNAFGSQ
Protein: BTB/POZ domain and ankyrin repeat-containing protein COCH (Protein COCHLEATA) (G8GTN7)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Involved in the promotion of leaf and floral meristem fate and determinacy. Promotes normal stipule growth and development. Down-regulates UNI expression in primordia of leaves and secondary inflorescences, and thereby controls their sizes and/or structures. Involved in the coordination of the symbiotic nodule developmental program. Necessary for the robust maintenance of nodule identity throughout the nodule developmental program.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:G3LSH3}. Cytoplasm {ECO:0000250|UniProtKB:G3LSH3}. Cell membrane {ECO:0000250|UniProtKB:G3LSH3}; Peripheral membrane protein {ECO:0000250|UniProtKB:G3LSH3}; Cytoplasmic side {ECO:0000250|UniProtKB:G3LSH3}.
Interaction partners:
Sequence:
MSLEDSLRSLSLDYLNLLINGQAFSDVVFSVEGRLVHAHRCILAARSLFFRKFFCGPDPPSGLDPSGNRVNSSTRSGVIPVNSVGYEVFLLMLQFLYSGQVSIVPQKHEPRPNCGDRGCWHTHCTSAVDLALDTLSAARYFGVEQLALLTQKQLASMVEKASIEDVMKVLLASRKQDMHQLWTTCSHLVAKSGLPPEVLAKHLPIDIIAKIEELRMKSSLSRRSLIPHHHHNPHHHHDHLTAAADLEDQKIRRMRRALDSSDVELVKLMVMGEGLNLDEALALPYAVESCSREVVKALLELGAADVNFPAGPTGKTPLHIAAEMVSPDMVAVLLDHHADPNVRTVDGVTPLDILRTLTSDFLFKGAVPGLTHIEPNKLRLCLELVQSAALVMSREEGNNNNNANNNNTGSSATNMYPHNHMNEEHHSHHNNNSNMDSRLVYLNLGANTQMSTSRLDSGDDDHNSNQREAMNPSMYHHHHSHDY
Protein: Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Damage-induced neuronal endopeptidase) (Xce protein) (Q9JHL3)
Organism: Rattus norvegicus (Rat)
Function: May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. Cleaves the synthetic substrate Z-Gly-Gly-Leu-pNA and releases pNA. May protect against C2-ceramide-induced apoptosis.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
Sequence:
MEAPYSMTAHYDEFQEVKYESRCGTGGARGTSLPPGFPRSSGRSASGARSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPGAAGTGGACPEGCPERKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEGSEKVLAAYKVFMERLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRDVSSVYNKVTLGQLQKITPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSPPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVDKEYEFEVHEKTYLKNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLHKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYYAYQKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW
Protein: cAMP-dependent protein kinase type II-alpha regulatory subunit (P13861)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit gamma
- cAMP-dependent protein kinase type II-beta regulatory subunit
- A-kinase anchor protein 1, mitochondrial
- A-kinase anchor protein 4
- A-kinase anchor protein 7 isoform gamma
- A-kinase anchor protein 10, mitochondrial
- A-kinase anchor protein 14
- cAMP-dependent protein kinase type I-beta regulatory subunit
Sequence:
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ
Protein: Insulator binding factor 1, isoform A (LD32555p) (Q9VHG5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Insulator binding factor 2
- Centrosome-associated zinc finger protein Cp190
- Zinc finger protein ZIPIC
- Boundary element associated factor
- Zinc finger protein su
- Modifier of mdg4
- CTCF
Sequence:
MPRKKSEDFYRTHGFTANLENGKYSATCHFCEKVLQNTALSRLSLHRQTCDARRSRSAVVYTSADEKDHDEAPRIKIQKISGDDDGGLDNANEGKEIIVKIQQILDDADEAEAPKEQPRVKREIRKRKLTKTEESGEQNLEFEISNVEIKNPEYSEYLDESKEHYILQQNPDDLANGSATIIEARPRNGLAALRAEKARAEISQFQSKTKFLKTETDNLKVERTLTLLKIQKLRLEIDALRD
Protein: REH2-associated factor 1 (Q585P3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Plays an important role in mitochondrial mRNA editing by promoting the assembly of the mRNA editosome. Facilitates the recruitment of mRNA to the REH2C complex and promotes the interaction between various editing complexes including REH2C, GRBC, REMC and RECC complexes.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:26769962, ECO:0000269|PubMed:31034523}.
Interaction partners:
- RNA editing associated helicase 2
- REH2-associated factor 2
- RNA-binding protein, putative
- Mitochondrial RNA binding complex 1 subunit
- Guide RNA associated protein, GAP2
- Pentacotripeptide-repeat region of PRORP domain-containing protein
- RNA editing 3' exouridylylase MP99
- RNA editing complex protein MP63
- RNA-editing ligase 1, mitochondrial
- RNA-editing ligase 2, mitochondrial
Sequence:
MRRWLVASMAPQLHQLLQPVRRCHHPLRIPSVQLAAPRSHTHEDIAYASCPACSRVVHMCDMLTHLITAHRELDQTHCRKMCTERLALYERVIGVPLKKSELTSSGRRVLDFLPTVLPTGYMCNWCDRRSDVYATRDKFLKHVADVHTDIDLEEVEPHVPLPPRGVVVEKSNGDGGPQPTRRLNGVVAVAEKSEPINAVPRILGISLPRGVDRPLKATAQFSDTEFPCELCNRTFNSEIDLLQHLETRHPDGTAEGPAGVDSAAIADVAQFSAKEATTGGDQRVHVICDLCVSSSKVYKMPSALFSHIRFKHPNEDAAFHVERLIREQKTVSSFVCTVCQKAFASAAALDGHFNSKHAEQGEAQNVVGRVTANNCWWCHDCEKGFSSAKGLHGHMQNKHGLSSQTHPCPACKRVFADIYSLEEHLSLQHKTIRLSDIGLLTHVKCSTCERFFLSHEDLHRHAVKHHKKDPRAPAQPFEAPTSASHVAASTSAAVPSEVEATASPQGPRKVKKRKKTTEVSEVTS
Protein: tRNA (pseudouridine(54)-N(1))-methyltransferase (EC 2.1.1.257) (D4GTL8)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00587}.
Interaction partners:
- tRNA pseudouridine synthase Pus10
- Purine-binding taxis protein CheW
- Protein-glutamate methylesterase/protein-glutamine glutaminase
Sequence:
MRQFIVTGHDAPTTPDFSLDDIAGGAGRLDVLCRCVNSAFFLSHDIREDVRVHLVLGDEYTVRFEGSELRRLNPDERSTAALIRKALEKREEAIGHMPAESSPGVSIRRMGFETTLEEAASDATVVELHEDGDPVVQVEPPENPLFVLSDHHDFTDEEAELLAAAADERVRLGPEILHADHSITVAHNYLDTAGYSRY
Protein: B3 domain-containing protein At5g24050 (Q9FLV7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00326}.
Interaction partners:
Sequence:
MTSIYHDDDDHLTASGKDLWSNFCVLVDAAVMLYEEEEEEQRRKIVSEEEEEFQKRIFCLFPRKTRSSLVKRQQNLIRVSTSSSLIDLNQFPTDSEIEDPQNHLQGLSSSCFIAANSETKTLQNPSSEPCSSLGLFGHKTAEYQKTETKDPPNPNFPCTMSLCLMENTSRKRRAVEQRKRSGGVKKANVAPFSQTARETPEWLVKVMTNMKEAKDAKLIFEKTLFVTDVNPTKNRLSMPFNNLLRNDFLTSVESIIINEDINNNNKIGVGAILVDQRCKKWGVMLKRWEMKKESGKGSWSYNLICGWNDIVEANRLKEGDNITLWSFRCCGILCFAMEQSSSSLALCLC
Protein: Monofunctional chorismate mutase (EC 5.4.99.5) (Q93LJ4)
Organism: Salmonella typhimurium
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate.
Subcellular location: Periplasm {ECO:0000269|PubMed:11532214}.
Interaction partners:
Sequence:
MIRHIAIFLCSLLMCSTTFADSVTSVSLGALLTALNERMLLMKDVAAYKMKHHLPIEDFTREQNVFAEAEEEAKNNGLDPHSITPFIRSLMDASKAIQYRYLAQWRTGSEPSFPIQTLSVTRQRIRQLDNQMLIIISQRLMVGAFSHDDMVWLRAQFNAPNLNESDISNVLAALSLVRRAR
Protein: Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1) (Q9H0J9)
Organism: Homo sapiens (Human)
Function: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Poly [ADP-ribose] polymerase 1
- Probable ATP-dependent RNA helicase DDX60
- 2'-5'-oligoadenylate synthase 3
- Ubiquitin-like protein ISG15
- Interferon-induced helicase C domain-containing protein 1
- Probable E3 ubiquitin-protein ligase HERC6
- Antiviral innate immune response receptor RIG-I
- Protein mono-ADP-ribosyltransferase PARP9
- Interferon-induced protein 44
- Protein mono-ADP-ribosyltransferase PARP14
Sequence:
MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAAAPERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTTEHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHICQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAPSRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYRWQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLSTASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGSDGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSIFVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
Protein: Probable carboxylesterase 17 (AtCXE17) (EC 3.1.1.1) (Q9LFR7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carboxylesterase acting on esters with varying acyl chain length.
Interaction partners:
- Protein ELF4-LIKE 2
- Gibberellin-regulated protein 10
- Protein ELF4-LIKE 3
- At2g14110 superfamily protein)
- Protein ELF4-LIKE 4
Sequence:
MATISFSHNHQSSDNRRGGSHHHRHGPVVEEIEGLIKVFNDGCVERPPIVPIVSPTIHPSSKATAFDIKLSNDTWTRVYIPDAAAASPSVTLPLLVYFHGGGFCVGSAAWSCYHDFLTSLAVKARCVIVSVNYRLAPEHRLPAAYDDGVNVVSWLVKQQISTGGGYPSWLSKCNLSNVFLAGDSAGANIAYQVAVRIMASGKYANTLHLKGIILIHPFFGGESRTSSEKQQHHTKSSALTLSASDAYWRLALPRGASRDHPWCNPLMSSAGAKLPTTMVFMAEFDILKERNLEMCKVMRSHGKRVEGIVHGGVGHAFHILDNSSVSRDRIHDMMCRLHNFIHPS
Protein: Rho-related protein rac1B (P34145)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Overexpression promotes the formation of filopodia and membrane ruffles.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
- Rac guanine nucleotide exchange factor B
- Ras guanine nucleotide exchange factor S
- GTPase activating protein homolog 1
- Putative rho GDP-dissociation inhibitor 1
- Serine/threonine-protein kinase pakB
- Cofilin-1A
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPASFENVNGKWHPEICHHAPNVPIILVGTKLDMREDRDTQDRLKEKKLYPVSYEQGLSKMKEINAVKYLECSALTQKGLKTVFDEAIRSVINPTLKKKPKSSKGCIIM
Protein: ATP-dependent DNA helicase Q4 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ4) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4) (O94761)
Organism: Homo sapiens (Human)
Function: DNA-dependent ATPase. May modulate chromosome segregation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15317757}. Nucleus {ECO:0000269|PubMed:10552928}.
Interaction partners:
- Fanconi anemia group M protein
- Protein MCM10 homolog
- Cell division control protein 45 homolog
- DNA repair protein RAD51 homolog 1
- Exonuclease 1
- Flap endonuclease 1
- Treslin
- DNA topoisomerase 3-alpha
- Chromosome transmission fidelity protein 18 homolog
- DNA topoisomerase 2-binding protein 1
Sequence:
MERLRDVRERLQAWERAFRRQRGRRPSQDDVEAAPEETRALYREYRTLKRTTGQAGGGLRSSESLPAAAEEAPEPRCWGPHLNRAATKSPQSTPGRSRQGSVPDYGQRLKANLKGTLQAGPALGRRPWPLGRASSKASTPKPPGTGPVPSFAEKVSDEPPQLPEPQPRPGRLQHLQASLSQRLGSLDPGWLQRCHSEVPDFLGAPKACRPDLGSEESQLLIPGESAVLGPGAGSQGPEASAFQEVSIRVGSPQPSSSGGEKRRWNEEPWESPAQVQQESSQAGPPSEGAGAVAVEEDPPGEPVQAQPPQPCSSPSNPRYHGLSPSSQARAGKAEGTAPLHIFPRLARHDRGNYVRLNMKQKHYVRGRALRSRLLRKQAWKQKWRKKGECFGGGGATVTTKESCFLNEQFDHWAAQCPRPASEEDTDAVGPEPLVPSPQPVPEVPSLDPTVLPLYSLGPSGQLAETPAEVFQALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLYSRRSPCLTLVVSPLLSLMDDQVSGLPPCLKAACIHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPPVAFACIDEAHCLSQWSHNFRPCYLRVCKVLRERMGVHCFLGLTATATRRTASDVAQHLAVAEEPDLHGPAPVPTNLHLSVSMDRDTDQALLTLLQGKRFQNLDSIIIYCNRREDTERIAALLRTCLHAAWVPGSGGRAPKTTAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPQGEDLRELRRHVHADSTDFLAVKRLVQRVFPACTCTCTRPPSEQEGAVGGERPVPKYPPQEAEQLSHQAAPGPRRVCMGHERALPIQLTVQALDMPEEAIETLLCYLELHPHHWLELLATTYTHCRLNCPGGPAQLQALAHRCPPLAVCLAQQLPEDPGQGSSSVEFDMVKLVDSMGWELASVRRALCQLQWDHEPRTGVRRGTGVLVEFSELAFHLRSPGDLTAEEKDQICDFLYGRVQARERQALARLRRTFQAFHSVAFPSCGPCLEQQDEERSTRLKDLLGRYFEEEEGQEPGGMEDAQGPEPGQARLQDWEDQVRCDIRQFLSLRPEEKFSSRAVARIFHGIGSPCYPAQVYGQDRRFWRKYLHLSFHALVGLATEELLQVAR
Protein: Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S) (Q9BZA7)
Organism: Homo sapiens (Human)
Function: Potential calcium-dependent cell-adhesion protein.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Homeobox protein TGIF2LY
- Putative serine/threonine-protein kinase PRKY
- Homeobox protein TGIF2LX
- Amelogenin, Y isoform
- Testis-specific Y-encoded protein 1
- Amelogenin, X isoform
- F-box-like/WD repeat-containing protein TBL1Y
- Polyadenylate-binding protein 5
Sequence:
MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNKQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLNSKHHIIQELPLDNTFVACDSISKCSSSSSDPYSVSDCGYPVTTFEVPVSVHTRPPMKEVVRSCTPMKESTTMEIWIHPQPQRKSEGKVAGKSQRRVTFHLPEGSQESSSDGGLGDHDAGSLTSTSHGLPLGYPQEEYFDRATPSNRTEGDGNSDPESTFIPGLKKAAEITVQPTVEEASDNCTQECLIYGHSDACWMPASLDHSSSSQAQASALCHSPPLSQASTQHHSPRVTQTIALCHSPPVTQTIALCHSPPPIQVSALHHSPPLVQATALHHSPPSAQASALCYSPPLAQAAAISHSSPLPQVIALHRSQAQSSVSLQQGWVQGADGLCSVDQGVQGSATSQFYTMSERLHPSDDSIKVIPLTTFTPRQQARPSRGDSPIMEEHPL
Protein: Protein BTG1 (Anti-proliferative factor) (B-cell translocation gene 1 protein) (Q63073)
Organism: Rattus norvegicus (Rat)
Function: Anti-proliferative protein.
Interaction partners:
- CCR4-NOT transcription complex, subunit 7.
Sequence:
MHPFYTRAATMIGEIAAAVSFISKFLRTKGLTSERQLQTFSQSLQELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFRLLPSELTLWVDPYEVSYRIGEDGSICVLYEASPAGGSSQNSTNVQMVDSRISCKEELLLGRTSPSKNYNMMTVSG
Protein: Myozenin-2 (Calsarcin-1) (FATZ-related protein 2) (Q9NPC6)
Organism: Homo sapiens (Human)
Function: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. {ECO:0000250}.
Interaction partners:
- Telethonin
- Alpha-actinin-2
- Cysteine and glycine-rich protein 3
- Myotilin
- LIM domain-binding protein 3
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Leiomodin-2
- Filamin-C
- Myosin light chain 3
- Myosin-7
Sequence:
MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTEPTDDTTVPESEDL
Protein: Small ribosomal subunit protein uS11 (40S ribosomal protein S14) (P62264)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62263}.
Interaction partners:
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein eS21
- Ubiquitin-ribosomal protein eS31 fusion protein
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein eL15
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL15
Sequence:
MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL
Protein: Uncharacterized protein YfdK (P77656)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YfdS
- Uncharacterized protein YgeI
- Uncharacterized protein YfdP
- Uncharacterized protein YfdT
- Uncharacterized protein YmfQ
- Hydrogenase-4 component J
Sequence:
MNYIYSATTNSFYPLEMKEDYTQAGSWPDDAVEVDEQVYIEFSGLPPKGKIRIAGENGFPAWSEIPPPTHEEQIAAAELKKQQLINQANDYMNSKQWAGKAAIGRLKGEELAQYNLWLDYLDALELVDTSSAPDIEWPTPPAVQAR
Protein: Type 2 DNA topoisomerase 6 subunit B (EC 5.6.2.2) (Type II DNA topoisomerase VI subunit B) (TopoVI-B) (Q8PUB8)
Organism: Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Interaction partners:
Sequence:
METPIAEELAKKQKSISVAEFFEKNRQILGFDSAPRSLITTVKEAVDNALDACEEAGILPDILVQVERTGPDYVTVIIEDNGPGIVREQIPKVFAKLLYGSRFHALKQSRGQQGIGISAAVLYAQMTAGRHTKILSKTSPTAPAHYYELMINTSTNEPDILVDEVRDWFRPHGTQIELEMRAAYVKGRRQSIYEYLKATAIVNPHARITLIDPDGNEEVFERATDKMPEPAEEILPHPEGIELGTLMKMLHYTERQKLAPFLRYSFCKIGLLTAEEICKAAGLDPEIDPHALGRHEARKLIEAFEKVKIMAPPTDCLSPIGEDLIYRGLEKETTVDFIATSTRKPAVYSGNPFVVEVGMAYGGNLPKEEKISIMRFANRVPLLYQQGGCVTTHAVEDIKWKQYGLNQPGGGIPVGPVILLIHVASINVPFTSESKDAIADIPVIKEEIDLAIKEVARKLKHYLSKQSNLKKRREKEIIITKVLPKLAAKVAHVLEKDVPDINPVVAKIMGNLLVHRVIKNNGDGTVDVAIKVKNFGTSAYSFRVHEMLPCKVSGAKPEPKVVTMGNDYDYVWDISASAGSSKVLSYKIESASEEELQKLPQLIVEGIEEELVTGAKAFKGV
Protein: LD23619p (Q961C4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIKCHMPSSWRRLRKISRILALTGSRQILTQVLATKGAAMAEGDSKFGFKDMEKALETLKLLESHDMQYRKLTVRGLLGRAKRVLTMTKAEEKLKNINAAIGVFEKWLEENGGGASSKNAKTESEDKVETVPGLGFKDKAAAEATLSILAERDPDYQRLAIKGLIGSSKRVLSGTKNEDKITAIKEGVQVLEDFLEKFEAENRIKDNRAYLPLAVVTKLPDPKDELAKEFLEAYGGSKAKGNYKHLRTMFPKTDEKTSWDIVRNRQLSKLLEQIKSEEAKLFDAETGAPTDLHLQLIHWAYSPQPDKLKQYIEKLAKKTPEKRKQESSSSASDSSATSQDSDGEDKPKRKKKREE
Protein: Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (OsNek3) (Q6ZEZ5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May be involved in plant development processes (Probable). May function downstream of DCW11 in retrograde signaling from the mitochondria to the nucleus. Seems to be involved in the mechanism of cytoplasmic male sterility (CMS) occurrence.
Interaction partners:
Sequence:
MEQYEVLEQIGKGSFGSALLVRHKVEKKRYVLKKIRLARQTDRCRRSAHQEMELIAKVRNPYIVEYKDSWVEKGCYVCIVIGYCEGGDMSEAIKKANSNYFSEERLCMWLVQLLMALDYLHVNHILHRDVKCSNIFLTKDQNIRLGDFGLAKVLTSDDLTSSVVGTPSYMCPELLADIPYGSKSDIWSLGCCLYEMTALKPAFKAFDMQTLINKISKSVLAPLPTIYSGAFRGLIKSMLRKSPDHRPSAAELLKHPHLQPFVLELQLKSSPARNLFPDTNKASCSDDENNWKAKYSKSHSFKVDRIVKVDKVAANNGHPSSTGTAKDYQELLKQPMDELLGQLTEKVVDEVIHGNHSRVTKSPAPTPRRASSTPRIRLEPSKTFHARAAETPPSKCSLERASQPTRRASTPVNMLQTPEKRQGADILTRLKSPDVSVNSPRIDRIAEFPIPSFDDEQLHPTTKLKLYPPSITDQSITKDKCTFQVLRSDSSKNHTGDSSDPSILGTDSNPLITSSSDWMKQRRFDTTSYRQRAEALEGLLEFSAQLLQQERFEELGILLKPFGPGKASPRETAIWLSKSFKGTGL
Protein: Hemagglutinin component of the neurotoxin complex (A5HZZ4)
Organism: Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Interaction partners:
Sequence:
MNSSIKKIYNDIQEKVINYSDTIDLADGNYVVRRGDGWILSRQNQILGGSVISNGSTGIVGDLRVNDNAIPYYYPTPSFNEEYIKNNIQTVFTNFTEANQIPIGFEFSKTAPSNKNLYMYLQYTYIRYEIIKVLQHEIIERAVLYVPSLGYVKSIEFNPGEKINKDFYFLTNDKCILNEQFLYKKILETTKNIPTNNIFNSKVSSTQRVLPYSNGLYVINKGDGYIRTNDKDLIGTLLIEAGSSGSIIQPRLRNTTRPLFTTSNDTKFSQQYTEERLKDAFNVQLFNTSTSLFKFVEEAPSDKNICIKAYNTYEKYELIDYQNGSIVNKAEYYLPSLGYCEVTNAPSPESEVVKMQVAEDGFIQNGPEEEIVVGVIDPSENIQEINTAISDNYTYNIPGIVNNNPFYILFTVNTTGIYKINAQNNLPSLKIYEAIGSGNRNFQSGNLCDDDIKAINYITGFDSPNAKSYLVVLLNKDKNYYIRVPQTSSNIENQIQFKREEGDLRNLMNSSVNIIDNLNSTGAHYYTRQSPDVHDYISYEFTIPGNFNNKDTSNIRLYTSYNQGIGTLFRVTETIDGYNLINIQQNLHLLNNTNSIRLLNGAIYILKVEVTELNNYNIRLHIDITN