wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) (P48766)
Organism: Cavia porcellus (Guinea pig)
Function: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:7986817}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Solute carrier family 8 member A2
- cAMP-dependent protein kinase
- cGMP-dependent protein kinase
- cAMP-dependent protein kinase catalytic subunit alpha
- Solute carrier family 8 member A3
- Solute carrier family 24 member 4
- cGMP-dependent protein kinase
- Fraser extracellular matrix complex subunit 1
Sequence:
MLRLSLSPTYSLGFHLLAMMTLLISHVDHITAETEMVEEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVAENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHISTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKHLYGQPVLRKVHARDHPIPSTVITIADEYDDKQPLTSKEEEERRIAELGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
Protein: FI20012p1 (Tropomodulin, isoform G) (A8JRH3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSDIEDVFGGSAEETKPEPDAQSKTSVVTEHTEEVIPGETEKMVTETIDEDGDVVEETTEVTRKTVKRTMKITETSATTKTTTLTTPAKLYGKDLSEYDDVDVESLLAQLSPEEITILAKEVDPDDNFLPPDQRNSYECTKEATGPLNRKQLIEHINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEEIIDLAAILGFHSMMNQDQYHASLLNKGQPVGLGWDGITKSTQQKLFPMDPPNNTDVEESIKRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGLHLEFNDARHRVAAHLQRNIDRIFRVQKLKPNLPKLILPGNMEIERDLVAYNRSATPSPSPSPQPPVDYEVEEDPDNMVIRGGGDAFDPDVDPDNMVVPGSRSVTPNYDDEGVYQAHTN
Protein: Muc3 protein (Q8R0K3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
QCTSLFYGPRCEELVESVEIEPTVAASVEVSVTVTSQEYSEKLQDRKSEEFSNFNKTFTKQMALIYAGIPEYEGVIIKNLSKGSIVVDYDVILKAKYTPGFENTLDTVVKNLETKIKNATEVQVQDVNNNCSALLCFNSTATKVQNSATVSVNPEETCKKEAGEDFAKFVTLGQKGDKWFCITPCSAGYSTSKNCSYGKCQLQRSGPQCLCLITDTHWYSGENCDWGIQKSLVYGLGGAGVAVLLVILVILLVFSIRFRKDAQRQRSRVSEMYKWGEEEGRASPGTFHNFGFDHNEERENYMPLDSVYNTFQPSLNHINPERKIQIQRPQVVMTSL
Protein: NLR family CARD domain-containing protein 3 (CARD15-like protein) (Caterpiller protein 16.2) (CLR16.2) (NACHT, LRR and CARD domains-containing protein 3) (Nucleotide-binding oligomerization domain protein 3) (Q7RTR2)
Organism: Homo sapiens (Human)
Function: Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination. Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation. Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15705585, ECO:0000269|PubMed:24560620, ECO:0000269|PubMed:25277106}.
Interaction partners:
- TNF receptor-associated factor 6
- Caspase-1
Sequence:
MRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQALDRTPDAPLGPCSNDSRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQLREHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLNTHEKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM
Protein: Alpha-1-antitrypsin 1-2 (AAT) (Alpha-1 protease inhibitor 2) (Alpha-1-antiproteinase) (Serine protease inhibitor 1-2) (Serine protease inhibitor A1b) (Serpin A1b) (P22599)
Organism: Mus musculus (Mouse)
Function: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
Subcellular location: Secreted {ECO:0000269|PubMed:11961105, ECO:0000269|PubMed:8619829}.
Interaction partners:
- Albumin
- Neutrophil elastase
- Alpha-1-antitrypsin 1-4
- Alpha-1-antitrypsin 1-1
- Alpha-1-antitrypsin 1-3
- Vitamin K-dependent protein C
- Alpha-2-HS-glycoprotein
- Fibrinogen alpha chain
- Haptoglobin
- Alpha-1-antitrypsin 1-5
Sequence:
MTPSISWGLLLLAGLCCMVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIVEAVKELDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDKSTTVKVPMMMLSGMLDVHHCSILSSWVLLMDYAGNASAVFLLPEDGKMQHLEQTLNKELISKILLNRRRRLVQIHIPRLSISGDYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSKAVHKAVLTIDETGTEAAAATVFEAVPMSMPPILRFDHPFLFIIFEEHTQSPIFVGKVVDPTHK
Protein: Small ribosomal subunit protein mS78 (rPPR3a) (Pentatricopeptide repeat-containing protein At1g55890, mitochondrial) (Q9LG23)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14671022, ECO:0000303|PubMed:36423343}.
Interaction partners:
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS11m
- Large ribosomal subunit protein uL24y
- Small polypeptide DEVIL 11
- Dentin sialophosphoprotein-like protein
- CLAVATA3/ESR
- Small polypeptide DEVIL 4
- Alpha/beta-Hydrolases superfamily protein
- Pentatricopeptide repeat-containing protein At1g26460
- Heavy metal-associated isoprenylated plant protein 6
Sequence:
MSSLSRVLRGTFNTCPIRRFSSAATVVSEPTAVTAAISPPQKSLTSLVNGERNPKRIVEKFKKACESERFRTNIAVYDRTVRRLVAAKRLHYVEEILEEQKKYRDMSKEGFAARIISLYGKAGMFENAQKVFEEMPNRDCKRSVLSFNALLSAYRLSKKFDVVEELFNELPGKLSIKPDIVSYNTLIKALCEKDSLPEAVALLDEIENKGLKPDIVTFNTLLLSSYLKGQFELGEEIWAKMVEKNVAIDIRTYNARLLGLANEAKSKELVNLFGELKASGLKPDVFSFNAMIRGSINEGKMDEAEAWYKEIVKHGYRPDKATFALLLPAMCKAGDFESAIELFKETFSKRYLVGQTTLQQLVDELVKGSKREEAEEIVKIAKTNDFLKLKLNLPSQEE
Protein: Two-component response regulator ORR33 (OsRRA19) (Q6ZC03)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. May directly activate some type-A response regulators in response to cytokinins.
Subcellular location: Nucleus {ECO:0000269|PubMed:22383541}.
Interaction partners:
Sequence:
MDQARISFFPDGLRVMIIDDDAKAVRRATATLSQLQYAVVATHSTASAGLRALSGDNVVEIQAILCDVHKVVSSGFDFRRVVESELRIPVIYLLSKMEEEDMVAGEDAEFLNHLLLTATYIVRKPLNPTVMARLWRVVAWRMYCLEERIQANVAANAGAGGEDDDDDDDVVIVEEPQVHFKVVRRTSGGSRKRQLTINVVDDGNRGSGSGGGGGGGADANPTRILQHITSNLQEFRTKHQKKDMAIERPLISSDSMFLKAILPTLKISPCNPLTLTGGIGSSSVAAEAFAGGSSSAAPLQIPVFQQQSTGNGNTVISFSNNASPMAMRAPTDNTMISFNNVSAAPVANAVISFSNISRSAAMQAPAARGQHLSGDVQQLDFPQQKLYFGPFSYQGPPPPSMHNHINLLPPTSSPVTCSMDKGKVPIIELPYGMPVDDFLVSQTTYGGAGPSIGATDAAAAAYPYTDAPSNNVATGCLMVPPMGPAFSITEPTVVAQGEGTGTGVDAGTSEKNAIVEAPNNPAPLMVLDQVAADAAMDVQEDIMFSLESLLGPDYDLLPMEDVSAPDTAAAGDAAGGSLDGEEGGMDIGWDLDLDDILVENVNDFAFLDNLAGSE
Protein: FXYD domain-containing ion transport regulator 5 (Dysadherin) (Q96DB9)
Organism: Homo sapiens (Human)
Function: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11756660}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97808}. Basolateral cell membrane {ECO:0000250|UniProtKB:P97808}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97808}. Note=In kidneys localizes to the basolateral membrane of the connecting tubule. {ECO:0000250|UniProtKB:P97808}.
Interaction partners:
- FXYD domain-containing ion transport regulator 3
- FXYD domain-containing ion transport regulator 6
- Cytochrome c oxidase subunit 7A1, mitochondrial
- FXYD domain-containing ion transport regulator 4
- FXYD domain-containing ion transport regulator
Sequence:
MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKAAHPTDDTTTLSERPSPSTDVQTDPQTLKPSGFHEDDPFFYDEHTLRKRGLLVAAVLFITGIIILTSGKCRQLSRLCRNRCR
Protein: Forked, isoform G (Q86B48)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MILRTRHTWRSSTDTEDYMQIQIAQQQSHPHQHQHHPHPHPHPHHPHQLHGMGEQPPLPPPPPPLPHGMLPPQPPMGPPMGVAGGQDATMSGKSHKPKKPHGSAPNSQDTATRKQHQPLSAISIQDLNSVQLRRTDTQKVPKPYQMPARSLSMQCLTSSTETYLKSDLIAELKISKDIPGIKKMKVEQQMASRMDSEHYMEITKQFSGNNYVDQIYLQIPERDQAGNAIPDWKRQMMAKKAAERAKKDFEERMAQEAESRRLSQIPQWKRDLLARREETENKLKAAIYTPKVEENNRVADTWRLKNRAMSIDNININLAGMEQHYQQIQFQQKQQQLQLGNKENHVDPKGADQDQEHGVGIGSGVGNANSGVIGGQELIDPSEGSQGRAEEEEDNIIPWRAQLRKTNSRLSLI
Protein: Packaging protein UL32 (P88958)
Organism: Human herpesvirus 8 type M
Subcellular location: Host cytoplasm {ECO:0000256|RuleBase:RU364029}. Host nucleus {ECO:0000256|RuleBase:RU364029}.
Interaction partners:
Sequence:
MSRGRSWSDAYSMLGSTGRGTHAPRHDGAHRERSKQLIQIFDSAASRFAEWSPALLHTHPRVSSNSQLTIQGNHRPVAMFVPWQLGTITRHRDELQKLLAASLLPEHPEESLGNPIMTQIHQSLQPSSPCRVCQLLFSLVRDSSTPMGFFEDYACLCFFCLYAPHCWTSTMAAAADLCEIMHLHFPEEEATYGLFGPGRLMGIDLQLHFFVQKCFKTTAAEKILGISNLQFLKSEFIRGMLTGTITCNFCFKTSWPRTDKEEATGPTPCCQITDTTTAPASGIPELARATFCGASRPTKPSLLPALIDIWSTSSELLDEPRPRLIASDMSELKSVVASHDPFFSPPLQADTSQGPCLMHPTLGLRYKNGTASVCLLCECLAAHPEAPKALQTLQCEVMGHIENNVKLVDRIAFVLDNPFAMPYVSDPLLRELIRGCTPQEIHKHLFCDPLCALNAKVVSEDVLFRLPREQEYKKLRASAAAGQLLDANTLFDCEVVQTLVFLFKGLQNARVGKTTSLDIIRELTAQLKRHRLDLAHPSQTSHLYA
Protein: Carboxylic ester hydrolase (EC 3.1.1.-) (Q24201)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
TIEHKVQQYRQSTNETVVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWEGVRDCSQPKDKAVQVQFVFDKVEGSEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFRFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRMGRGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLYDDNKDLLF
Protein: Tetratricopeptide repeat protein 9C (TPR repeat protein 9C) (Q8N5M4)
Organism: Homo sapiens (Human)
Interaction partners:
- Heat shock protein HSP 90-alpha
Sequence:
MEKRLQEAQLYKEEGNQRYREGKYRDAVSRYHRALLQLRGLDPSLPSPLPNLGPQGPALTPEQENILHTTQTDCYNNLAACLLQMEPVNYERVREYSQKVLERQPDNAKALYRAGVAFFHLQDYDQARHYLLAAVNRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFG
Protein: Empty spiracles homeobox 1 (F8W1B5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MNHPALTVHPAHQLGASPLQPPHSFFGAQHRDPLHFYPWVLRNRFFGHRFQASDVPQDGLLLHGPFARKPKRIRTAFSPSQLLRLERAFEKNHYVVGAERKQLAGSLSLSETQVRRVGVGLSDPQPSCCPGGGFQSLRAGRLPELRE
Protein: Rabaptin, RAB GTPase binding effector protein 2 (H3BT64)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
PAIEGVGPVTALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDT
Protein: NAC (No Apical Meristem) domain transcriptional regulator superfamily protein (NAM (No apical meristem) protein-like) (Q9LSI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Expansin-A2
- RING-H2 finger protein ATL73
Sequence:
MEETEKNKGSISMVEANLPPGFRFHPRDDELVCDYLMRRTVRSLYQPVVLIDVDLNKCEPWDIPQTARVGGKEWYFYSQKDRKYATGYRTNRATATGYWKATGKDRAIQRNGGLVGMRKTLVFYRGRSPKGRKTDWVMHEFRLQGKLLHHSPNSLEEEWVLCRVFHKNSNGADIDDITRSCSDATASAFMDSYINFDHHHIINQHVPCFSNNLSHNQTNQSGLISKNSSPLFNASPDQMILRTLLSQLTKKVEESQSRGDGSSESQLTDIGIPSHAWNY
Protein: Protein HGH1 (HMG1/2 protein homolog) (P48362)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Hsp70/Hsp90 co-chaperone CNS1
- Putative uncharacterized protein YJR018W
- Elongation factor 2
- Protein-lysine N-methyltransferase EFM2
- U3 small nucleolar RNA-associated protein 5
- Altered inheritance rate of mitochondria protein 29
- MIOREX complex component 12
- Regulator of rDNA transcription protein 14
- Uncharacterized protein YCR016W
- 25S rRNA
Sequence:
MTSQLNELVEFLHSPQPAVRQIAIDNLVGFSAGPTSKVFKNDSYRPIKDIIKMIMDPEHGTRVIIQQGVTILVNLSEDKLVRNIILSDDKKFLKFLVWKIVDLTNPNADIMCILLSNLAKDDGILAVLNIKRNSSGEEVDDGLKLAALNKEVFKSLRAMDCLMDCFVKGYDKKLTKYASFNYLAFFFADISRFKLGRMYFIEEQEYDGVVPISKLLVFTEKYDAKVRREGVASTIKNSLFDSETHERLLKDEKINLLPYILLPIASAKDSEIDEEDMFNLPDELQLLPEDKERDPIPAIICCHLESILLLCTTHAGREYLRDKSVYPLVRELHKNVENEDIGELCYRIVNMLMRGEPGAGAVEEMPSKNAEEEEEEESEEEEDDDEEDEIVEVA
Protein: Rab-like protein 2B (Q9UNT1)
Organism: Homo sapiens (Human)
Function: Small GTPase required for ciliation. Activated in a guanine nucleotide exchange factor (GEF)-independent manner via its intrinsic GDP for GTP nucleotide exchange ability. Involved in ciliary assembly by binding the intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28428259}. Cytoplasm {ECO:0000269|PubMed:28625565}. Note=Localizes on the mother centriole. Localizes slightly apical to the subdistal appendage, but below the distal appendage. {ECO:0000269|PubMed:28625565}.
Interaction partners:
- SH3 and multiple ankyrin repeat domains protein 3
- Centrosomal protein of 19 kDa
- DCC-interacting protein 13-beta
- Dol-P-Man:Man
- Centrosomal protein 43
- Centrosome-associated protein 350
Sequence:
MAEDKTKPSELDQGKYDADDNVKIICLGDSAVGKSKLMERFLMDGFQPQQLSTYALTLYKHTATVDGRTILVDFWDTAGQERFQSMHASYYHKAHACIMVFDVQRKVTYRNLSTWYTELREFRPEIPCIVVANKIDDINVTQKSFNFAKKFSLPLYFVSAADGTNVVKLFNDAIRLAVSYKQNSQDFMDEIFQELENFSLEQEEEDVPDQEQSSSIETPSEEAASPHS
Protein: E3 ubiquitin-protein ligase E3D (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase E3D) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein) (Q7Z6J8)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:39032490}.
Interaction partners:
- E3 ubiquitin-protein ligase RBBP6
- Ubiquitin-conjugating enzyme E2 C
- Cleavage and polyadenylation specificity factor subunit 3
Sequence:
MAASAAETRVFLEVRGQLQSALLILGEPKEGGMPMNISIMPSSLQMKTPEGCTEIQLPAEVRLVPSSCRGLQFVVGDGLHLRLQTQAKLGTKLISMFNQSSQTQECCTFYCQSCGEVIIKDRKLLRVLPLPSENWGALVGEWCCHPDPFANKSLHPQENDCFIGDSFFLVNLRTSLWQQRPELSPVEMCCVSSDNHCKLEPKANTKVICKRCKVMLGETVSSETTKFYMTEIIIQSSERSFPIIPRSWFVQSVIAQCLVQLSSARSTFRFTIQGQDDKVYILLWLLNSDSLVIESLRNSKYIKKFPLLENTFKADSSSAWSAVKVLYQPCIKSRNEKLVSLWESDISVHPLTLPSATCLELLLILSKSNANLPSSLRRVNSFQVAFLKM
Protein: Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) (Q8NBJ4)
Organism: Homo sapiens (Human)
Function: Unknown. Cellular response protein to viral infection.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12191016}; Single-pass type II membrane protein {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12191016}. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
Interaction partners:
- Golgi phosphoprotein 3
- Glypican-3
- Alpha-fetoprotein
Sequence:
MMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIMELEGRVRRAAAERGAVELKKNEFQGELEKQREQLDKIQSSHNFQLESVNKLYQDEKAVLVNNITTGERLIRVLQDQLKTLQRNYGRLQQDVLQFQKNQTNLERKFSYDLSQCINQMKEVKEQCEERIEEVTKKGNEAVASRDLSENNDQRQQLQALSEPQPRLQAAGLPHTEVPQGKGNVLGNSKSQTPAPSSEVVLDSKRQVEKEETNEIQVVNEEPQRDRLPQEPGREQVVEDRPVGGRGFGGAGELGQTPQVQAALSVSQENPEMEGPERDQLVIPDGQEEEQEAAGEGRNQQKLRGEDDYNMDENEAESETDKQAALAGNDRNIDVFNVEDQKRDTINLLDQREKRNHTL
Protein: Alpha-toxin To2 (Alpha-toxin Tc48a) (Alpha-toxin To48a) (PT-alpha' NaTx11.1) (P60212)
Organism: Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Function: Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Affects the tetrodotoxin-sensitive sodium current permeability of F-11 rat neuroblastoma cells. Produces a dose dependent increase in amplitude and duration of the current.
Subcellular location: Secreted {ECO:0000269|PubMed:11821128, ECO:0000269|PubMed:15025998}.
Interaction partners:
Sequence:
MIRFVLFISCFFLIGTVVECNKDGYLMEGDGCKMGCLTRKASYCVDQCKEVGGKDGYCYAWLSCYCYNMPDSVEIWDSKNNKCGKGK
Protein: Complement factor H (H factor 1) (P08603)
Organism: Homo sapiens (Human)
Function: Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.
Subcellular location: Secreted.; SUBCELLULAR LOCATION: Note=(Microbial infection) In the mosquito midgut, localizes to P.falciparum (NF54 strain) macrogamete and young zygote cell membranes. {ECO:0000269|PubMed:23332154}.
Interaction partners:
- Complement C3
- Complement factor I
- C-reactive protein
- Complement C4-A
- Complement factor B
- Apolipoprotein E
- Age-related maculopathy susceptibility protein 2
- Complement C4-B
- Endogenous retrovirus group 3 member 1 Env polyprotein
- Syncytin-2
Sequence:
MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Protein: Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) (Q6PBX1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSDDEKLPSGWEKRMSRSSGRVYYFNHITNASQWERPSGSGADGAGDVEKVRCSHLLVKHSQSRRPSSWREENITRSKDEALQLIQKYIEQIKSGEEEFESLASQFSDCSSARNGGDLGLFGRGQMQKPFEDASFALKVGDMSGPVFTDSGVHIILRTG
Protein: 4 protein (Complement control protein) (Complement regulatory protein) (O41927)
Organism: Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Interaction partners:
Sequence:
MANFHFFCAVLVGIVGVNGDNMCHHLPQMPTLTSPKFTPPVKSGTTLQLRCRPGFTPGAGGRKTVTCLGDNMWTTVTPCNRKRCPHVTFPTNGGANYHFKDNDTSPSYGTEAVFYCDPGYNLLGESKLFCELQDNNKVGWSGESPICDIKKCAPPEVKSPAYILRAKDVYNTREVTRFSCPINLKLYGPTHAVCEGPGWTPSTSPFCLEIPCGQPTIPHATIQSKPGAPPGSRELVVNCDPGYMPLDGTTLTCEGRGVWKLPLPECVASKPGNDGHSYVTPGISEAPEVPTSSDMSTTTWSTRKLTSNTPPDPEVQTLGSYEYEPDEPVYPTSPQTASTASPVTQTVPPPKKSSLMMVFKLLGLLLIIPLLIVSVAVLGFLITRCCRL
Protein: RNA-binding protein with serine-rich domain 1 (H3BTC0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHRSRSSSN