wanglab/gogpt-training-data huggingface dataset:
Protein: Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22) (Q5ZM44)
Organism: Gallus gallus (Chicken)
Function: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription. Acts as a negative regulator of the calcineurin/NFAT signaling pathway.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P61023}. Cytoplasm {ECO:0000250|UniProtKB:P61023}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P61023}. Endomembrane system {ECO:0000250|UniProtKB:P61023}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:P61023}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P61023}. Cell membrane {ECO:0000250|UniProtKB:P61023}. Membrane {ECO:0000250|UniProtKB:Q99653}; Lipid-anchor {ECO:0000250|UniProtKB:Q99653}.
Interaction partners:
- Sodium/hydrogen exchanger
- Calcium/calmodulin dependent protein kinase I
- Uncharacterized protein.
- Coronin
Sequence:
MGSRASTLLRDEEIEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFSEGEDQVNFRGFMRTLAHFRPIEDNEKSKDQNGPEPLNSRSNKLHFAFRLYDLDKDDKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDCAISFAEFVKVLEKVDVEQKMSIRFLH
Protein: Carabin (TBC1 domain family member 10C) (Q8IV04)
Organism: Homo sapiens (Human)
Function: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.
Interaction partners:
- RAS protein activator like-3
- Rho GTPase-activating protein 9
- Ras-related protein Rab-35
- TRAF3-interacting JNK-activating modulator
Sequence:
MAQALGEDLVQPPELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF
Protein: F-box domain-containing protein (Q4GYB5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFLKEGNSEMRLSGATFLKGAVDDFNACESPVLSSGSSLVLTSPALSTSDTCRSAMRETIPSVCAGAGLSSRCSTDCTVLKCVNPLHVKFQEPSGLSGADSVDSFDSLGDLSELHEEHQHVSSVASEKPLTLHDVPESVLYGAIPYLSLPDVIALSRTCKKFHKLVQGYFAVNEHGVMSIPAFDTRSFMQYRPERKPPVTKASSMEPATKASDVKPIRLFFGQQRRDPHPSALRRLLRFIAPDLVIAHMEAHTNPVNGRGKGCAWVFALSQLDAERLLRLSGRIFLDINSNGEEVYLFAPPNCREWLNEHAECAVASAVRPSHLPRQPMVVEAPRKSSAKVEKGLEQCVRPHPQHRGVTEQQAPVAAAQQMPDSVEPLVRVGSPQDEGLQQQERPSEAWTTSNHLQGDSTHGRRRSGEALQSGESTPERLQARRRPWLVAADASATQRARELRFCSNSSTSLHHEMWGFHPGARLGSGVGGDRFIACPETTTRTVPHNVYTSTIWTGPRRFRHDPYVYGPLCVLAAS
Protein: RFX-like DNA-binding protein RFX2 (Q5AMQ6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
Interaction partners:
- Serine/threonine-protein kinase MEC1
- Transcriptional regulator of filamentous growth FLO8
- Transcription factor ROB1
- Galactose-responsive transcription factor
- Transcriptional regulatory protein UME6
- Biofilm regulator 1
- Hypha-specific G1 cyclin-related protein 1
Sequence:
MSNNPHRTHKRQKSSVSNPGYYFTPETKSEIQQQQPQQQESQQQQQQQQQQHSQTHNIYDNDNYMNYNFPPTSNRPRASTTTGTTSTTHPGSELSHESHSVHTSPLKRTASSELDQPIPAMAPSSPLVSSAPYYYQQPSQQQNLSYHDHHHQQQQQQSTPQGQQLSQQTQSNSQSGVPPPLYGTSSSIPPGSTMQPSTSFAFHTSHSTYNPSFDSSNLYNSAFRLPEYPTTSSSSLLSTTGGKQFQQSSALLPSGTLPPSILGTSSSSHVSALRQHQKNNLSISSHLTLFSLSGNNSSQLQSQGSSFQQSETGVDDTKRSSKESTTIFNDLLFHLTSVDGSNINTFLLSILRKINSPFTLDDFYNLLYNDRQRTLLDNSNYQNRIDKTIVSPSDTDMTVSIINQLLNFFKTPSMLVDYFPNMEDKDNKLANINYHELLRTFLAIKILHDILIQLPISEDDDPQNYTIPRLSIYKTYYIICQKLIASYPSASNTRNEQQKLILGQSKLGKLIKLVYPNLLIKRLGSRGESKYNYLGVMWNANIVQEEIKQLCDEHELNDLNEIFNSDNNNPFASIAPSGSATTGSTPRRGLSHKRTSSKQKIKTEPVAGNPFLQPLQTSHHHHHSHHHHHEEQSQEESLSQQMGEHITAPRLSFLRANSKYPTDVNLSVLDDDNWFVRLSYECYARQPALNRDLIQQIFLKNEFLLNNSSLLQNLMDSIIKPLVMQETYSNVDLVLYLAILLEILPYLLLVKSSTNINLLKNLRLNLLHLINNFNNELKKLDSPKFPIERSTIFLVLVKKLINLNDLLITFIKLINRDNCKTTMSSDIENFLKINSQTVKLDDDDNSFFFNLNTTSMGEVNFNFKNEILSNDLIYTLIGYNFDPTTNSELKSSISMNFINEEINVIDEFFKNDLLNFLSTDFHAGLDDDNGEEDDDEEAGPGSTHPMGATGSQGSLSPEPVSTGNPSVPPTRNTSISEVNAENKRGNEAVLTPKETAKLNSLISLIDKRLLSSQFKSKYPILMYNNCISYILNDILKHIFLKQQQQQLQSSSSQLHDTQPLTQQDTAQGIGSSSSNANNTNSSFGNWWVFNSFIQEYMSLIGELVGLHDNLV
Protein: Mitochondrial import inner membrane translocase subunit tim21 (O94618)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit tim50
- Mitochondrial import inner membrane translocase subunit tim23
- Mitochondrial import inner membrane translocase subunit tim17
- Mitochondrial import inner membrane translocase subunit tim14
- Mitochondrial import inner membrane translocase subunit tim44
- Mitochondrial import inner membrane translocase subunit tim16
- Protein mgr2
- Mitochondrial import inner membrane translocase subunit tim9
- Presequence translocated-associated motor subunit pam17
- GrpE protein homolog
Sequence:
MIRTIQRQSATRFSSALVQRRLYSLASDSLNKQRKPQEEGRLARIFKDPSNKAWKDLTAPQKAYRTSANIGNFSIVIFGGGVFGLIIYALVTSIWKGEAHYGDEAFELLKANEECRYVFGDHMKALGEATHPLRRTHGILTSRVWDHHGVEHLVLQFHLIGNERKGHVFGRLVNVQGDYKWEYLFVDVANYGKIIIFDHTNSVRQQHKNFGLWGSLKNITWGN
Protein: Telomere repeat-binding factor 3 (AtTRB3) (MYB transcription factor) (Telomere-binding protein 2) (AtTBP2) (Q9M2X3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds preferentially double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:19947985}. Nucleus, nucleolus {ECO:0000269|PubMed:19947985}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:19947985}. Note=Localized to the nucleolus during interphase.
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL18y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS1z
Sequence:
MGAPKLKWTPEEETALKAGVLKHGTGKWRTILSDPVYSTILKSRSNVDLKDKWRNISVTALWGSRKKAKLALKRTPLSGSRQDDNATAITIVSLANGDVGGQQIDAPSPPAGSCEPPRPSTSVDKIILEAITSLKRPFGPDGKSILMYIEENFKMQPDMKRLVTSRLKYLTNVGTLVKKKHKYRISQNYMAEGEGQRSPQLLLEGNKENTPKPEENGVKNLTKSQVGGEVMIMGMTEKEAAAAAARAVAEAEFAMAEAEEAAREADKAEAEAEAAHIFAKAAMKAVKYRMHSQTR
Protein: Zinc finger BED domain-containing protein 6 (P86452)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity). Positively regulates the cell cycle and survival of pancreatic beta cells. Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity). May also play a role in embryonic beta cell differentiation (By similarity). May play a role in insulin sensitivity and glucose clearance (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:24043816}. Nucleus, nucleolus {ECO:0000250|UniProtKB:D2EAC2}. Cytoplasm {ECO:0000269|PubMed:24043816}. Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus (By similarity). Mainly cytoplasmic in insulin- and glucagon-positive islet pancreatic cells, however nuclear localization is evidence in some pancreatic endocrine cells (PubMed:24043816). {ECO:0000250|UniProtKB:D2EAC2, ECO:0000269|PubMed:24043816}.
Interaction partners:
- Zinc finger CCCH domain-containing protein 11A
- Insulin-like growth factor 2
Sequence:
MSVCTLSVPVSSLSPGRRCNTFSDSGILGCVPINSNTDEEDVVEEKMVAEGVNKEAKQPAKKKRKKGLRIKGKRRRKKLILAKKFSKDLGSGRPVADAPALLASNDPEQDEESLFESNIEKQIYLPSTRAKTSIVWHFFHVDPQYTWRAICNLCEKSVSRGKPGSHLGTSTLQRHLQARHSPHWTRANKFGVASGEEDFTLDVSLSPSSGSNGSFEYIPTDPLDDNRMGKKHDKSASDALRAERGRFLIKSNIVKHALIPGTRAKTSAVWNFFYTDPQHISRAVCNICKRSVSRGRPGSHLGTSTLQRHLQATHPIHWAVANKDSGAVANGLDEAETERSDLLSDTLHGEKSTGSQDLTAEDLSDSDSDEPMLEVENRSESPIPVAEQGTLMRAQERETTCCGNPVSSHISQAIIQMIVEDMHPYNYFSTPAFQRFMQIVAPDYRLPSETYFFTKAVPQLYDCVREKIFLTLENVQSQKIHLTVDIWTHDPSTDYFIVTVHWVSLETASFLNNGRIPDFRKWAVLCVTGLAKDCLITNILQELNDQIGLWLSPNFLIPSFIVSDNSSNVVHAIKDGGFTHVPCFLHCLNMVIQDFFCEHKSIENMLVAARKTCHHFSHSVKARQILQEFQNDHQLPWKNLKQDETGHWISTFYMLKWLLEHCYSVHHSLGRASGVVLTSLQWTLMTYVCDILKPFEEATQKVSVKTAGLNQVLPLIHHLLLSLQKLREDFQVRGITQALNLVDSLSLKLETDTLLSAMLKSKPCILATLLDPCFKNSLEDFFPQGADLETYKQFLAEEVCNYMESSPEICQIPTSEASCPSVTVGADSFTSSLKEGTSSSGSVDSSAVDNVALGSKSFMFPSAVAVVDEYFKEKYSEFSGGDDPLIYWQRKISIWPALTQVAIQYLSCPMCSWQSECIFTKNSHFHPKQIMSLDFDNIEQLMFLKMNLKNVNYDYSTLVLSWDPEQNEVVQSSEKEILP
Protein: Endoribonuclease ysh1 (EC 3.1.27.-) (mRNA 3'-end-processing protein ysh1) (O13794)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA polyadenylation factor fip1
- mRNA cleavage and polyadenylation specificity factor complex subunit pta1
- mRNA 3'-end-processing protein yth1
- Uncharacterized RING finger protein P8B7.15c
- RNA polymerase II subunit A C-terminal domain phosphatase ssu72
- Polyadenylation factor subunit 2
- Protein cft1
- Cleavage factor two protein 2
- Uncharacterized protein C4G9.04c
- Poly
Sequence:
MSKRKEFDEDAPVDPSDLLEFINLGAGNEVGRSCHVIQYKGKTVMLDAGVHPAYTGLSALPFFDEFDLSTVDVLLISHFHLDHVASLPYVMQKTNFRGRVFMTHPTKAVCKWLLSDYVKVSNVGMEDQLYDEKDLLAAFDRIEAVDYHSTIEVEGIKFTPYHAGHVLGACMYFVEMAGVNILFTGDYSREEDRHLHVAEVPPKRPDVLITESTYGTASHQPRLEKEARLLNIIHSTIRNGGRVLMPVFALGRAQELLLILDEYWNNHLDLRSVPIYYASSLARKCMAIFQTYVNMMNDNIRKIFAERNPFIFRFVKSLRNLEKFDDIGPSVILASPGMLQNGVSRTLLERWAPDPRNTLLLTGYSVEGTMAKQITNEPIEIVSLSGQKIPRRMAVEELSFAAHVDYLQNSEFIDLVNADHIILVHGEQTNMGRLKSALASKFHNRKVDVKVYTPRNCVPLYLPFKGERLVRALGKVAVHKPKEGDIMSGILIQKDANYKLMSAEDLRDFSDLTTTVLTQKQVIPFFSSMELANFHLKQMFGYVKQSKTKAGQPQYTVMDAITLTLIQEHKLALEWVGNIMNDTIADSVITILLGIESSPASVKLTSHKCNHLHSHLDKPPKVSKEEDRIKKLMMFLDNQFGESMTKTEKGVEIKFEKYEASIDFSTMKVECSNEALRSRVVHVLSRAINTILPFSEASQNDVSEDDFENEESDDDKIFEQQTKIEDDVKNENKTEPVEEQKSEEKNEQPNLKKEELS
Protein: Uncharacterized protein (Q57XQ7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 50S ribosomal protein L7Ae, putative
- Telomerase-associated protein, putative
- H/ACA ribonucleoprotein complex subunit
Sequence:
MSGSFAQHGSKGGTSGGPRRNVKPSAKMGKATNVKKEAKRYHKEKYAREQVERRGHHAQQHTAVGNHEGRSHQRSARTKDIDIHLAAKVSSELRSDLSSFKTRLNATNIFGADLSEIFKFVPPPFIQQHLPEDVRSLRSYLSKFERGAPNSVQAFIVWYEWAEYELNKGKGRGGGTKKHYDNKAQGLTSGDEEEEAAAASDQKDGEQVETHGKVSRSRAVLAKNVKEREHVRALLQMCLRHNSTRRKEGQHSLINHLKAKLVDGVDCRSLKSMRDTAHHALPYALSRMLLGMVTEDMAMIVLHAHILFLALRETDITPSIVLSLIGEEIALDARLKVTKARLEARAARRDTQGEQQKEDQGDWDDFDPDTINDPTRGERNQRIVAAVFAMGAVVANRGKMRVEDARHAAQYLCFAYVEQKATRVMTAALLLITLQKFPKLWEDESVMEWISYAFFLYPKLEYFRPEGVQLLLRLMAMETKPPAIKKFLPTTVQKYAAMDPLEPTTVEQIANALFRKEQVIAVYPMVHPVWDDWFDLLVQRCAAGESLQEHLSTMMHNAIAPYRRGNSDIPRRALFQQLVARLGQLVVKNDDADQRQEMLKIASQAVGYGRKIVAKASDPNELRMMPLEMLDAKVRDLIKQYFCIRDSDPSAHANRTWVLRELRACLSVPLREGVTCTYVDEAVRALLRFGFYPTPKSSDEKCMNRAIYLFSDVFSFTYTAALSRPKCTLSALSVIRDYLAAEEKGITRYTTGATERNFRKARNCIVEALESSSTRSVLFYEERDIHVLLVLLFLILSTDDPSNEEAKNLANSTVPDLCQFFRTGTLETLDLFYDVLMALVMRPSSALHVLPLMVCVRRIATGYLLRFARYVRERPTLDLVLAPLREAYHTDDRELIRQAKAKGVAAEAEDSSADEEEGDEEDENNEGTQVDEKDEDEEDEGGDVPSEDEADKTETETETEADESEEPTEEDEATEPEEGADEEQLNPDVEDEESDTGDEEEEEAPTQQYIDALKGMIGNVDLQFVYPTDTANKEKGDVVRAIQVATRVGVAMRSPLTVHIFQVLLAVCRENVKAADDVIFNSTVSSLQMLMMTKNRYFGRFLVAESLFQLLSDIQSYCRKLDRVLVNKESRSARHALVVRRRMTRLKDVALRVFHFIAFLAHKNHAGEDVRVTLMEFYKSIFCDRGWDGKKRMPSVKRDMHHYRHGFAWALLPAALEKFSEVEVLEGPQRVRVFQGCCQMVEAVLPRLSGLGATLRASAASAISSFLQSVTPTSVYNMKYTLLYDYLHCLKMVLKYNSRVQLDTAWASNIVKEVVDDDSLMTSAATIRLLAAMENLLNLTPRARETKAPSPVSVLYKQYEKSGRKEKAAFYRRAKRVRKKVVRALAAHRNGELTDEEKAAKRRRRETLRINDRLERQMIRTERSQILTKEEREEKRKRIMVAKQERIAKNRERKRRLHEQREKAFQRWREQKLAAAAVADE
Protein: Transporter (B5X4N9)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Collectrin
- Y+L amino acid transporter 2-like
- Angiotensin-converting enzyme
- Collectrin-like isoform X3
- Angiotensin-converting enzyme
Sequence:
MRFPKLPNPGLDDRIPSHQELERMEKEEAGDRPKWDNKTQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLHLEFAIGQRLRSGSVGVWTAINPYLTGVGIASLLVSFLVGMYYNTIIAWVMWYFFNSFQNPLPWSQCPVNANLTGLVSECARSSPVDYFWYRDTLNTSTSIGDSGGLQWWMVLCLLCAWLLLYVCCLRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGSLDGIKFLFTPDLNELMNPSTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEQDAVIISIINGFTSVYAATVIYSIIGFRATERFDDCLEGNILALLNAVNLPEGNITEGNYAESLQNLNGTFPEIIQSLDLKTCDLQTFLSQGVEGTGLAFIVFTEAITKMPISPLWSILFFIMLFCLGLSTMFGSIEGTVVPLQDLNIFPKWWPKEAITGIVCLVSFIIALIFAQSSGNYWLALFDSFAGSIPLLVIAFCEMIAVVYIYGIDRFNKDIEFMIGHKPNLFWQVTWRFVSPLIVLVIFVFYFVTKVSSNVTYIAWNPSSDDFPTLEVLEYPAWIYVIIFILAGIPSLVVPGTALFKLIQRCCCDKNVYGAEVDTVSAKVQMFTTKMS
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (Q8IRS0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MDCATRKQQQLRAHHQQQQIQIQTHGRKRQQLQKQRHNHHHYYQNSQQQQKHFVWLVVGILTIFLAQHANAADLVINVPNASSNANAFYRIDYSPPFGFPEPNTTIPASDIGKDIKFSRALPGTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVL
Protein: Transcription factor nrm1 (Negative regulator of MBF targets 1) (O42913)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Negative regulatory component of the MBF complex involved in cell-cycle-dependent transcription.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Cell division cycle-related protein res2/pct1
- MBF complex negative regulatory component yox1
- Start control protein cdc10
- Transcriptional activator protein rep2
- Cell division control protein 18
- Cell division cycle-related protein res1/sct1
- Ribonucleoside-diphosphate reductase large chain
- G2/mitotic-specific cyclin cig2
Sequence:
MDRSMEPLTPSRLNTLGERPTNEVYEYGKGKNVQHLFPITPMQRPLGKENAAPGTISPIAVRSRNVRAVEIADENACEEPVLKIKSVSSTESEEEKESSTEIGEKQEKETHLEPKTPVQTNTNNNHLDDIQCCAKNLRLRLELAMYKVQVNQTFSPLQDLPIVAKTKLHNCPNSEPVTSIWNQRSLSSGKPPSLHLSGNRRLSMGSPTKSIYDQNGLTTPRPIGSDDLTHMYDPYTSPLRTPSRTLSRSSSHYLWVRHGKLTRSVSLLQHKTPRRIRPKSLSKSNSTPLKHLSAQKPNSNYYTGPPTPVSISNTPENIHPSSSEVRRIASHSKQFSDYGLIR
Protein: Histone deacetylase (EC 3.5.1.98) (Q8T6T6)
Organism: Trypanosoma brucei
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR037913}.
Interaction partners:
Sequence:
MNEDGDCRRVALIDTSCYSADCTLSALVPQHAMKPYRLLVTMELIASLGLKRFCRTVVPPPIGIKELLTYHAEDYVLNLGLHSNRSWLWNTEVSKVTFSGDCPPVEGIVEYSLSTVSGSLMAAVLLNSGAVDTAIHWGGGMHHAKCGECSGFCYVNDIVIAIIELLKCHDRVLYVDLDMHHGDGVDEAFCRSRRVFTLSLHKFGESFFPGTGHPRDVGIGNGRHYTMNLALWDGVDDFYYTTVFERALRSIVRRFNPNVVVLQCGADSLAGDRLGHFNLSSWGHGKCVEEVKKLGLPMLVVGGGGYTLRNVAKLWAYETSILCGKRLPLNTVIPLHRMPLSGWLFEESPQLLVSQDEENKPLPGVNVQRSFRVIIEQIDKHCPNIMTV
Protein: Carboxyl-terminal protease (P73458)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Glutaminase
Sequence:
MLKQKRSLILGTTALLLTTVAVTGVGLRLARSQGYLQDNPKELVDEVWQIVNRTYVDGTFNGEDWVAVRQDYLTRDYKNQEEAYTAIREMLEKLNDPYTRFMSPDEFQSMRIDTSGELTGVGIQITQDQDTKKIVVVAPIEDTPAYNAGILSKDVITKIDGKSTDGMEVDDAVKLIRGKPGTSVVLTIEREGQAIEYPLTRTLIEIHPVRAQVEDINGARVGYIRLNQFSAQASEEMRQAVQKLEKENVVGYIFDLRSNPGGLLYSSVDIARIWLDEGGIVSTVDRRGEVEQQSANKRQLSNRPLVVLVDGGSASASEIVSGALQDNQRAVIVGTKTFGKGLVQSVRELGDGSGMAVTIAKYLTPNGRDINKHGIDPDVEVELTDAQRKELQQNREKVGTLEDPQFARAYEVLMQQVNKTASK
Protein: Pyruvate decarboxylase (EC 4.1.1.1) (P83779)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15378761}.
Interaction partners:
- Fructose-bisphosphate aldolase
- Pyruvate kinase
- alcohol dehydrogenase
- Enolase 1
- Alcohol dehydrogenase 2
- Glucose-6-phosphate isomerase
- Phosphoglycerate kinase
- Transketolase
- Aldehyde dehydrogenase
- Transaldolase
Sequence:
MSEITLGRFFFERLHQLKVDTVFGLPGDFNLALLDKIYEVEGMRWAGNANELNAGYAADGYARVNPNGLSALVSTFGVGELSLTNAIAGSYSEHVGVINLVGVPSSSAQAKQLLLHHTLGNGDFTVFHRMFKNISQTSAFIADINSAPAEIDRCIRDAYVYQRPVYIGLPSNLVDMKVPKSLLDKKIDLSLHPNDPESQTEVIETVEKLISEASNPVILVDACAIRHNCKPEVAKLIEETQFPVFTTPMGKSSVDESNPRFGGVYVGSLSKPEVKESVESADLILSIGALLSDFNTGSFSYGYKTRNIVEFHSDYTKIRQATFPGVQMKEALQKLLTTVKKSINPNYTPVPVPETKLINTPAAPSTPLTQEYLWTKVSSWFREGDIIITETGTSAFGIVQSRFPKNSIGISQVLWGSIGYTVGATCGAAMAAQELDPKRRVILFVGDGSLQLTVQEISTMCKWECNNTYLFVLNNDGYTIERLIHGEKAQYNDIQPWNNLQLLPLFNAKDYETKRISTVGELNDLFADKAFAVPDKIRMVEVMLPTMDAPANLVAQAKLSEKTNAEQ
Protein: Protein RALF-like 1 (Rapid alkalinization factor 1) (AtRALF1) (Q9SRY3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases. Mostly active in roots. Prevents plant growth (e.g. root and leaf length). Suppresses cell elongation of the primary root by activating the cell surface receptor FER and triggering phosphorylation of AHA2 and subsequent extracellular alkalinization.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- GPI-anchored protein LLG1
- Serine/threonine-protein kinase RIPK
- GPI-anchored protein LORELEI
- Receptor-like protein kinase ANXUR1
- Ferritin-4, chloroplastic
- Receptor-like protein kinase THESEUS 1
- Leucine-rich repeat extensin-like protein 1
- Leucine-rich repeat extensin-like protein 5
- Leucine-rich repeat extensin-like protein 4
- Receptor-like protein kinase ANXUR2
Sequence:
MDKSFTLFLTLTILVVFIISSPPVQAGFANDLGGVAWATTGDNGSGCHGSIAECIGAEEEEMDSEINRRILATTKYISYQSLKRNSVPCSRRGASYYNCQNGAQANPYSRGCSKIARCRS
Protein: Megsin (Q920J5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MASLAAANAEFGFDLFREMDSSQGNGNVFFSSLSIFTALSLIRLGARGDCARQIDKALHFISPSRQGNSSNSQLGLQYQLKRVLADINSSHKDYELSIANGVFAEKVFDFHKSYMECAENLYNAKVERVDFTNDIQETRFKINKWIENETHGKIKKVLGDSSLSSSAVMVLVNAVYFKGKWKSAFTKSDTLSCHFRSPSGPGKAVNMMHQERRFNLSTIQEPPMQILELQYHGGISMYIMLPEDDLSEIESKLSFQNLMDWTNSRKMKSQYVNVFLPQFKIEKDYEMRSHLKSVGLEDIFVESRADLSGIASGGRLYVSKLMHKSLIEVSEEGTEATAATESNIVEKLLPESTVFRADRPFLFVIRKNGIILFTGKVSCP
Protein: Arf guanine nucleotide exchange factor sec74 (Q10491)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Guanine nucleotide exchange factor for Arf GTPases, stimulating the nucleotide exchange from the GDP-bound to the GTP-bound form. Involved in vesicular transport (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Cell tip {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized calcium-binding protein C800.10c
- Actin cytoskeleton-regulatory complex protein end3
Sequence:
MDESSRIASSSALHGLDEMVSAHKPSPPLPSRRKGKSALRSALEKKNRKSKSKPKVTITSDTPKVSSQHSPVSSAYTGDSTTDLDSKSGHSSSQKLSNKVSSALKLTIPKRWRSSKSSSSQCSSPFLPTSSSNGHGDDASLNLPDKKSRPSSQSSIFLSNWSTIFSSNASPTDSQLSPTHTSTIAELAASTLSIFPSGSYAGSTFGSPSRSSIDSSTYLPRSKSVNSLSSNFSARTPASNQSSVSEDFGAAPNCDHKHNSVTLSDFALPDIDQHDTVETILEKVEFTIPKQFTPAILSQGTSSLLKLCLRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYDSSDECYILTFSLMILHTDFFNIHNRQKMTRAEFISNTNLPTILPEILECFYDNITYTPFVHVEHIGCVVTSPSNEKPSLSQRLGDSQFRLTKRNTFATESDHQALQEQLTGFRINLDSILDLKKIDSVRTSIESPTRTADDLYKEFARAPFLQIVSHRSQPQAFSYHFEPSAESESTNPAIINVKVFKLGILIQNEKVRKDRLLSNREVGVILTSSQLMFFKNVYWISGLLDQLEDFKRSHSFSPCYFSPHLTSLSADYIIPLSDLVAYGDGSRIENELYSFSVKQKNQRTHVFSVTNVDELNDWLVKINFVSTFATAGLAPRERLPCVESSDKSIKASVSVLPDIYEDSDAMSKASKETRSEVLECSKVRVYIVQNRIYKLEEALRQGESKMTVQRRNAANILHLEPIQSRTRIRLARCSNTLKKNMLAQMIEIQKFKISIKFLKEDLEMDSHLQDYLRSVFPSSVMGKENASEDTILESNFRNHSNPSVRRSNLRVGKTVESVQNTKLKSVENDSGKAETETVGKNPEVVRKSPAKLPNIANIMTVNGHRYSVVELPDDFLRE