wanglab/gogpt-training-data huggingface dataset:
Protein: Tumor necrosis factor receptor superfamily member 23 (Decoy TRAIL receptor 1) (TNF receptor family member SOB) (TNF receptor homolog 1) (Tumor necrosis factor receptor p60 homolog 1) (Q9ER63)
Organism: Mus musculus (Mouse)
Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis through ligand competition. Cannot induce the NF-kappa-B pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12466268}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12466268}.
Interaction partners:
- Caspase-8
Sequence:
MVTFSHVSSLSHWFLLLLLLNLFLPVIFAMPESYSFNCPDGEYQSNDVCCKTCPSGTFVKAPCKIPHTQGQCEKCHPGTFTGKDNGLHDCELCSTCDKDQNMVADCSATSDRKCECQIGLYYYDPKFPESCRPCTKCPQGIPVLQECNSTANTVCSSSVSNPRNWLFLLMLIVFCI
Protein: RNA binding motif protein Y-linked family 1 member F (J3KQ82)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGTSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSSGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNHRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREAYGSSSYVASIVDGGESRSEKGDSSRY
Protein: Phenylalanine ammonia-lyase 2 (EC 4.3.1.24) (P45728)
Organism: Petroselinum crispum (Parsley) (Petroselinum hortense)
Function: This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MENGNGAITNGHVNGNGMDFCMKTEDPLYWGIAAEAMTGSHLDEVKKMVAEYRKPVVKLGGETLTISQVAAISARDGSGVTVELSEAARAGVKASSDWVMDSMNKGTDSYGVTTGFGATSHRRTKQGGALQKELIRFLNAGIFGNGSDNTLPHSATRAAMLVRINTLLQGYSGIRFEILEAITKFLNQNITPCLPLRGTITASGDLVPLSYIAGLLTGRPNSKAVGPTGVILSPEEAFKLAGVEGGFFELQPKEGLALVNGTAVGSGMASMVLFEANILAVLAEVMSAIFAEVMQGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSAYVKAAQKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRSSTKMIEREINSVNDNPLIDVSRNKAIHGGNFQGTPIGMSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSGGRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISSRKTSEAVEILKLMSTTFLVGLCQAIDLRHLEENLKSTVKNTVSSVAKRVLTMGVNGELHPSRFCEKDLLRFVDREYIFAYIDDPCSATYPLMQKLRQTLVEHALKNGDNERNMNTSIFQKIATFEDELKALLPKEVESARAALESGNPAIPNRIEECRSYPLYKFVRKELGIEYLTGEKVTSPGEEFDKVFIAMSKGEIIDPLLECLESWNGAPLPIC
Protein: Trypanosoma Tc-38 (p38) protein domain-containing protein (Q381H4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRGVFYLTGVLLKRKRLSTVHTEVSVLSSVTNAPFSPSCQAALRSVAKERHYVKRHWLTLAQSRRSCNAVVLPGEAPTIIHLNVKSVIPFSSVPKSVQKRIMDEHPPFFGSGVGILSTRMKWKSVTGDRLRRFLNEEESDRVLYIDTDIASELGVQVNRKDVIDIRKQSSVSVYSAEQLDDPYKGEPQRGITLNAATGKRLGQPAHDILLAVGILRGYTSPMWVAEKQLKHLNLEVNKGCENEGVLAPNMTGFVVSLSSIPKEAQKELLKELQEDHPDAFGYDLYFIYGVNGWEVMRSRVLVKSMAAVNDPRYPYHFVNVRDFGLQKPKYSAFAEACDHKVQLLRGKSVRKPPEPHDEDAKNHKLDASSIVRSFSITVGASRSPVPIRGFLAEDATLRRYYNAVCLTEPHLAVPAIRSIAVLNGKLVGRRDEAKLRAFALKHKLSSPIWVTPLGAKRMGVGIEKKHINNYVLIGSASIEEYDDDSGGGTNEEFYNIDDLVNPDEVLSIFPKSSKSAHFMLDSKWRPVLGKQRQAFLTSLKRRSPLWVTVSECLMSGFQALPEVKPISFPVAKKGGGVEGGHKLYNSQFTTDPVRVIGLATIYTRPQGTTL
Protein: Chromosome partitioning protein ParA (B8GW31)
Organism: Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Function: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication.
Interaction partners:
Sequence:
MSANPLRVLAIANQKGGVGKTTTAINLGTALAACGERVLLIDADPQGNCSTGLGIGRTQRRTTLYDVLMGEAPVVDAAVKTELPGLDVIPADADLSGVEIELGQTARRSYRLRDALEAIRANGPYTYVLIDCPPSLNVLTVNAMTAADAVFVPLQCEFFALEGLTQLMRTIERVRGSLNPRLEIQGVVLTMYDRRNSLSEQVAKDVRAHFGDKVYDAVIPRNVRVSEAPSFGKPVLLYDLKCAGSQAYLKLAREVISRERDRQAKAA
Protein: G2-specific protein kinase fin1 (EC 2.7.11.1) (O13839)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Promotes chromosome condensation and nuclear envelope dynamics during mitosis. Activity appears at metaphase-anaphase transition.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:11927555}.
Interaction partners:
- Anaphase-promoting complex subunit 3
- Spindle assembly checkpoint serine/threonine-protein kinase bub1
- Mitotic spindle checkpoint component mad2
Sequence:
MEKYKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQEKQYIADEVNILRNLKHPNIVQYCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYRCHYGENAPACDSQWPREIFHPKQSVLHRDIKPANIFLDENNSVKLGDFGLSKLLDNTRVFTQSYVGTPYYMSPEIIRSSPYSAKSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQGNLSCWDHHYSDDVFLLIRHCLEVNSDLRPTTYQLLRSPILSDIRSKLESERVVLEQSDLLHKKHQMLIQLENDLQFREQRLSARESELENVIASRLAQREEILRRELEKQLRDMDARYQRHMQTVVNSMQKMRVTSPVDHNEQPESSTAEMFVDCTIEASQSPLLHIPKLGISKPLQTLSCPGFTLTTQQPILKRPTLRKELSSRALHTTATLMKYRANASSLRTTPIDKDGQITSLQQKNGTSNQVADCMNKLLHTSLDGKKLSPSELCNKFSDGEGLPNRKVSKLSVESDETAVSASSGESVPTDSTLTDTKSKSVFVHPPSPQSLYVEKLEKLNIRSDEVSKPSKASKTLHGYALPSLASPYDVHAEEKIARENEMDGNFKTMKINQHPDEYVLRTPKKIQLLEGQKRSPVKQLGRLGYNKLRRSAMDNAGLELRKAASTSNYTSLQSRTLPGSWRDDEEEIPRPFLRKMLDARMMRA
Protein: Zinc finger protein 230 (Zinc finger protein FDZF2) (Q9UIE0)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Fructose-bisphosphate aldolase
- Fructose-bisphosphate aldolase A
Sequence:
MTTFKEAVTFKDVAVFFTEEELGLLDPAQRKLYQDVMLENFTNLLSVGHQPFHPFHFLREEKFWMMETATQREGNSGGKTIAEAGPHEDCPCQQIWEQTASDLTQSQDSIINNSHFFEQGDVPSQVEAGLSIIHTGQKPSQNGKCKQSFSDVAIFDPPQQFHSGEKSHTCNECGKSFCYISALRIHQRVHLREKLSKCDMRGKEFSQSSCLQTRERVHTGEKPFKCEQCGKGFRCRAILQVHCKLHTGEKPYICEKCGRAFIHDFQLQKHQIIHTGEKPFKCEICGKSFCLRSSLNRHCMVHTAEKLYKSEECGKGFTDSLDLHKHQIIHTGQKPYNCKECGKSFRWSSYLLIHQRIHSGEKPYRCEECGKGYISKSGLNLHQRVHTGERPYNCKECGKSFSRASSILNHKKLHCRKKPFKCEDCGKRLVHRSFCKDQQGDHNGENSSKCEDCGKRYKRRLNLDIILSLFLNDM
Protein: Regulatory protein SWI4 (Cell-cycle box factor subunit SWI4) (Protein ART1) (P25302)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).
Interaction partners:
- G1/S-specific cyclin CLN1
- Regulatory protein SWI6
- G1/S-specific cyclin CLN3
- Transcription factor MBP1
- Protein BCK2
- G1/S-specific cyclin CLN2
- S-phase entry cyclin-5
- G1-specific transcriptional repressor WHI5
- Cyclin-dependent kinase 1
- Zinc finger protein RME1
Sequence:
MPFDVLISNQKDNTNHQNITPISKSVLLAPHSNHPVIEIATYSETDVYECYIRGFETKIVMRRTKDDWINITQVFKIAQFSKTKRTKILEKESNDMQHEKVQGGYGRFQGTWIPLDSAKFLVNKYEIIDPVVNSILTFQFDPNNPPPKRSKNSILRKTSPGTKITSPSSYNKTPRKKNSSSSTSATTTAANKKGKKNASINQPNPSPLQNLVFQTPQQFQVNSSMNIMNNNDNHTTMNFNNDTRHNLINNISNNSNQSTIIQQQKSIHENSFNNNYSATQKPLQFFPIPTNLQNKNVALNNPNNNDSNSYSHNIDNVINSSNNNNNGNNNNLIIVPDGPMQSQQQQQHHHEYLTNNFNHSMMDSITNGNSKKRRKKLNQSNEQQFYNQQEKIQRHFKLMKQPLLWQSFQNPNDHHNEYCDSNGSNNNNNTVASNGSSIEVFSSNENDNSMNMSSRSMTPFSAGNTSSQNKLENKMTDQEYKQTILTILSSERSSDVDQALLATLYPAPKNFNINFEIDDQGHTPLHWATAMANIPLIKMLITLNANALQCNKLGFNCITKSIFYNNCYKENAFDEIISILKICLITPDVNGRLPFHYLIELSVNKSKNPMIIKSYMDSIILSLGQQDYNLLKICLNYQDNIGNTPLHLSALNLNFEVYNRLVYLGASTDILNLDNESPASIMNKFNTPAGGSNSRNNNTKADRKLARNLPQKNYYQQQQQQQQPQNNVKIPKIIKTQHPDKEDSTADVNIAKTDSEVNESQYLHSNQPNSTNMNTIMEDLSNINSFVTSSVIKDIKSTPSKILENSPILYRRRSQSISDEKEKAKDNENQVEKKKDPLNSVKTAMPSLESPSSLLPIQMSPLGKYSKPLSQQINKLNTKVSSLQRIMGEEIKNLDNEVVETESSISNNKKRLITIAHQIEDAFDSVSNKTPINSISDLQSRIKETSSKLNSEKQNFIQSLEKSQALKLATIVQDEESKVDMNTNSSSHPEKQEDEEPIPKSTSETSSPKNTKADAKFSNTVQESYDVNETLRLATELTILQFKRRMTTLKISEAKSKINSSVKLDKYRNLIGITIENIDSKLDDIEKDLRANA
Protein: Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (Antigen CD42b-alpha) (CD antigen CD42b) [Cleaved into: Glycocalicin] (P07359)
Organism: Homo sapiens (Human)
Function: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- von Willebrand factor
- Platelet glycoprotein IX
- Filamin-A
- Platelet glycoprotein Ib beta chain
- P-selectin
- Prothrombin
- Integrin alpha-M
- Platelet glycoprotein V
- 14-3-3 protein zeta/delta
- Integrin beta-2
Sequence:
MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL
Protein: Cold shock-like protein CspB (CSP-B) (P36995)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Cold shock-like protein CspG
- Cold shock-like protein CspF
- Uncharacterized protein YnaE
- Cold shock-like protein CspI
- Prophage lysis protein S homolog EssQ
- 30S ribosome-binding factor
Sequence:
MSNKMTGLVKWFNADKGFGFISPVDGSKDVFVHFSAIQNDNYRTLFEGQKVTFSIESGAKGPAAANVIITD
Protein: Paired mesoderm homeobox protein 1b (Paired-related homeobox 1b) (Q6P295)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MTSSYAHVMDRQATISSRLESPITANLENLQAKKNFSVSHLLDLEEAREMVGSQVDESVGETGRTMLESPGLTSGSDTTQQENEQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLASKNASLLKSYSGDVTAVEQPIVPRPAPRPNDYLSWGSAAPYSTMATYPPTCANTTSTQGMNMANSIANLRLKAKEYNLNQVPTVN
Protein: Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC 1.17.4.2) (Gp50) (Q05262)
Organism: Mycobacterium phage L5 (Mycobacteriophage L5)
Interaction partners:
Sequence:
MTDEIPWGPTGELVYNRTYARTKPDGSKETWPETVERVVDGNLALVDRRHMLEGEREDLVRLMTKFKVLPAGRHLWASGVKNAQHLFNCWVAGWPEKISDHFQFTFMRLMEGGGVGANYSNHYLEGYPEVVNPLRVEIVCDPEHVDYQAMKDVGILSEHYSHDWAGAYAIEDSREGWAAALVDLIDTHYRPGTVHYQRVYDVSRIRPQGAKLKTFGGVASGPLPFAVMLQKVANIFSEYAGITLDGIAAMEVDHAIAQCVVAGGVRRSARMSMMHWDDYQIDKFINIKASTGEHWTTNISVEVDDEFWRLAKEGYGSFAVAREDMPKQKRAHRVLKALSEGAVRNGEPGMWDSSLSNVGEPNRVVCTNPCGEITLEPWEPCNLGHINLAAFVTPAGKTDYLDLIRAHRLMTRFLIRATFSEVADPKSREVLDRNRRIGVGHLGVASYLALTGSRYSEAPGDKRFTQFLREMAAEVDSEAERFAHDLRIPVPVKKRTIAPTGTVAKMPGVSEGIHPIFSRYFIRRVRFNLNSDMAELRRLAAEGYEIEKDLFAPNTEVVSIPTKDTLVQAVEELGWDEEIVESADELTLHQLLAFQALYQMCWADNAVSFTANVHPDAYEAEDVAADLKRFAGLIKGSTIFPESSFPQAPYERITKQQYESAAAKAVEDGVDEECANGACPIK
Protein: Interleukin (Q6UG49)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MCKVLIFGCISVATLMTTAYGASLSSAKRKPLQTLIKDLEILENIKNKIHLELYTPTETQECTQQTLQCYLGEVVTLKKETEDDTEIKEEFVTAIQNIEKNLKSLTGLNHTGSECKICEANNKKKFPDFLHELTNFVRYLQK
Protein: Nedd8-activating enzyme E1 regulatory subunit (Beta-amyloid precursor binding protein 1) (dAPP-BP1) (Q9VTE9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulatory subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Appl and APP-BP1 interact antagonistically during development.
Interaction partners:
- Nedd8-activating enzyme E1 catalytic subunit
- Ubiquitin-like protein NEDD8
- Nedd8-conjugating enzyme UbcE2M
- Cullin homolog 1
- Cullin 3, isoform F
- Large ribosomal subunit protein uL1
- Deneddylase 1, isoform C
- COP9 signalosome complex subunit 5
- Amyloid-beta-like protein
- Molybdopterin synthase catalytic subunit
Sequence:
MSSPAPKSPELSDKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKEEDLGNNFFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASNLNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTEVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPDMTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRIAEEYEKSSRLLPLVEDNELQGNLTAYNFALRAYERFLSECGNIPGECIVEQDIGRLKSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDNTFIYNAITTESVTLKL
Protein: Single-strand selective monofunctional uracil DNA glycosylase (EC 3.2.2.-) (Q53HV7)
Organism: Homo sapiens (Human)
Function: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.
Subcellular location: Nucleus {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:12161446}.
Interaction partners:
- Uracil-DNA glycosylase
- G/T mismatch-specific thymine DNA glycosylase
- Thymidylate synthase
- Methyl-CpG-binding domain protein 4
- DNA repair nuclease/redox regulator APEX1
- Probable inactive tRNA-specific adenosine deaminase-like protein 3
- N-glycosylase/DNA lyase
- DNA polymerase lambda
- Endonuclease 8-like 1 lyase Neil1)
- Uracil phosphoribosyltransferase homolog
Sequence:
MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVSMVRDWLGIVGPVLTPPQEHPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFHHCFVHNLCPLLFLAPSGRNLTPAELPAKQREQLLGICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLMPEVQVEGLLHPSPRNPQANKGWEAVAKERLNELGLLPLLLK
Protein: Transcription factor TCP22 (Q9C7G4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- WD repeat-containing protein LWD1
- WD repeat-containing protein LWD2
- Suppressor of RPS4-RLD 1
- Transcription factor TCP5
- Protein CCA1
- Transcription factor TCP4
- Ubiquitin carboxyl-terminal hydrolase 15
- Transcription factor TCP24
- Transcription factor TCP12
- Transcription factor TCP13
Sequence:
MNQNSSVAEATLQLNSGEKPSPGSIPFISSGQHGNISTSATSSTSTSSGSALAVVKSAVKKPTKDRHTKVDGRGRRIRMPAMCAARVFQLTRELGHKSDGETIEWLLQQAEPAIIASTGTGTIPANFSTLNASLRSGGGSTLFSQASKSSSSPLSFHSTGMSLYEDNNGTNGSSVDPSRKLLNSAANAAVFGFHHQMYPPIMSTERNPNTLVKPYREDYFKEPSSAAEPSESSQKASQFQEQELAQGRGTANVVPQPMWAVAPGTTNGGSAFWMLPMSGSGGREQMQQQPGHQMWAFNPGNYPVGTGRVVTAPMGSMMLGGQQLGLGVAEGNMAAAMRGSRGDGLAMTLDQHQHQLQHQEPNQSQASENGGDDKK
Protein: SLIT-ROBO Rho GTPase activating protein 2 (A0A075B7E9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
ECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINNNLHLDNTKPVTTKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPA
Protein: Fiber protein (SPIKE) (Protein IV) (P11818)
Organism: Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Function: Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host coxsackievirus and adenovirus receptor CXADR located at the cell tight junctions to provide virion initial attachment to target cell. The fiber protein binds to CXADR with a higher affinity than CXADR binds to itself, thereby blocking the cell-cell adhesion function of CXADR dimers and leading to local disruption of the tight junction. Fiber protein present on neo-synthesized particles may thus disrupt the junctional integrity in order to facilitate further neighboring cells infection. Fiber proteins are shed during virus entry, when virus is still at the cell surface. Fiber shedding is dependent on viral CXADR drifting motion and subsequent binding to immobile integrins. Heparan sulfate might also play a role in virus binding (By similarity).
Subcellular location: Virion {ECO:0000250}. Host nucleus {ECO:0000250}. Note=Anchored to the pentons, protrudes from the virion surface. Present in 36 copies per virion (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MKRARPSEDTFNPVYPYDTETGPPTVPFLTPPFVSPNGFQESPPGVLSLRLSEPLVTSNGMLALKMGNGLSLDEAGNLTSQNVTTVSPPLKKTKSNINLEISAPLTVTSEALTVAAAAPLMVAGNTLTMQSQAPLTVHDSKLSIATQGPLTVSEGKLALQTSGPLTTTDSSTLTITASPPLTTATGSLGIDLKEPIYTQNGKLGLKYGAPLHVTDDLNTLTVATGPGVTINNTSLQTKVTGALGFDSQGNMQLNVAGGLRIDSQNRRLILDVSYPFDAQNQLNLRLGQGPLFINSAHNLDINYNKGLYLFTASNNSKKLEVNLSTAKGLMFDATAIAINAGDGLEFGSPNAPNTNPLKTKIGHGLEFDSNKAMVPKLGTGLSFDSTGAITVGNKNNDKLTLWTTPAPSPNCRLNAEKDAKLTLVLTKCGSQILATVSVLAVKGSLAPISGTVQSAHLIIRFDENGVLLNNSFLDPEYWNFRNGDLTEGTAYTNAVGFMPNLSAYPKSHGKTAKSNIVSQVYLNGDKTKPVTLTITLNGTQETGDTTPSAYSMSFSWDWSGHNYINEIFATSSYTFSYIAQE
Protein: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BTB/POZ domain-containing protein TNFAIP1) (Tumor necrosis factor-induced protein 1) (Q7TNY1)
Organism: Rattus norvegicus (Rat)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis (By similarity). May enhance the PCNA-dependent DNA polymerase delta activity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endosome {ECO:0000250}. Note=Colocalizes with RHOB in endosomes. {ECO:0000250}.
Interaction partners:
- UBX domain-containing protein 1
- FAS-associated factor 1
- Cullin-3
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
- Potassium channel tetramerization domain-containing 13.
- Rho family GTPase 2
- UBX domain-containing protein 7
- UBX domain-containing protein 7
- E3 ubiquitin-protein ligase RBX1
- Potassium channel tetramerization domain containing 17
Sequence:
MSGDTCLCPASGAKPKISGFKGGGLGNKYVQLNVGGSLHYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMAEAKYYLIQGLVSLCQAALQDKKDSYQPVCNIPIITSLREEDRLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEDTFELRDRVRRIHVKRYSTYDDRQLGHQSAHRD
Protein: Low-affinity glucose transporter HXT3 (P32466)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Low-affinity glucose transporter.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Low-affinity glucose transporter HXT1
- Low-affinity glucose transporter HXT4
- High-affinity glucose transporter HXT2
- High-affinity hexose transporter HXT6
- Probable glucose transporter HXT5
- High-affinity hexose transporter HXT7
- Carbon catabolite-derepressing protein kinase
- Protein STD1
- Glucose transport transcription regulator RGT1
Sequence:
MNSTPDLISPQKSSENSNADLPSNSSQVMNMPEEKGVQDDFQAEADQVLTNPNTGKGAYVTVSICCVMVAFGGFVFGWDTGTISGFVAQTDFLRRFGMKHKDGSYYLSKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVAPKEMRGTLVSCYQLMITLGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGGMTFVPESPRYLVEAGQIDEARASLSKVNKVAPDHPFIQQELEVIEASVEEARAAGSASWGELFTGKPAMFKRTMMGIMIQSLQQLTGDNYFFYYGTTVFNAVGMSDSFETSIVFGVVNFFSTCCSLYTVDRFGRRNCLLYGAIGMVCCYVVYASVGVTRLWPNGEGNGSSKGAGNCMIVFACFYIFCFATTWAPIAYVVISETFPLRVKSKAMSIATAANWLWGFLIGFFTPFITGAINFYYGYVFMGCMVFAYFYVFFFVPETKGLTLEEVNDMYAEGVLPWKSASWVPTSQRGANYDADALMHDDQPFYKKMFGKK
Protein: Probable transport protein MmpL1 (P9WJV9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable transport accessory protein MmpS1
- Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0726c
Sequence:
MRSQRLAGHLSAAARTIHALSLPIILFWVALTIVVNVVAPQLQSVARTHSVALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYDVLVTKLSQDTTHVQHIENFWGDPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQRIVDSVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQEARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASLTLAPAIIAVASRFGLFDPKRATTKRRWRRIGTVVVRWPGPVLAATLLIALIGLLALPKYQTNYNERYYIPSAAPSNIGYLASDRHFPQARMEPEVLMVEADHDLRNPTDMLILDRIAKTVFHTPGIARVQSITRPLGAPIDHSSIPFQLGMQSTMTIENLQNLKDRVADLSTLTDQLQRMIDITQRTQELTRQLTDATHDMNAHTRQMRDNANELRDRIADFDDFWRPLRSFTYWERHCFDIPICWSMRSLLNSMDNVDKLTEDLANLTDDTERMDTTQRQLLAQLDPTIATMQTVKDLAQTLTSAFSGLVTQMEDMTRNATVMGRTFDAANNDDSFYLPPEAFQNPDFQRGLKLFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTPLQAASIYLAGTSSTYKDIHEGTLYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVLIWQHILHMPLHWLVLPMAIIVMLAVGSDYNLLLIARFQEEIGAGLKTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSYMTPALATLLGRWFWWPRRVDRLARQPQVLGPRRTTALSAERAALLQ
Protein: Large ribosomal subunit protein eL37x (60S ribosomal protein L37-3) (Q8LEM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to the 23S rRNA.
Interaction partners:
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL24y
- Large ribosomal subunit protein uL24z
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein eL29z
- At1g43860
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL29y
Sequence:
MGKGTGSFGKRRNKSHTLCVRCGRRSFHIQKSRCSACAYPAARKRTYNWSVKAIRRKTTGTGRMRYLRNVPRRFKTGFREGTEAKPRSKASASSA
Protein: Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) (F7FH41)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369118}.
Interaction partners:
Sequence:
VSSASSSSLFAAAAAAAPLPAGGCRCRCRCRHHRLWGPRAERRPPRSTNPAVPPAAEGPGPAWPAPPAPPARASVRPPAPAGPAWRGRPPPPRSSSCSGGPRPAASRACRPALRAAPPPPSAPRGAPRSRPPCPARPRAVGPGSTPSNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDDLYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCAENTVLSSGLTAAR