wanglab/gogpt-training-data huggingface dataset:
Protein: Semaphorin-5A (Semaphorin-F) (Sema F) (D3ZTD8)
Organism: Rattus norvegicus (Rat)
Function: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Plexin-B3
- Semaphorin 5B
- Plexin-A1
- Plexin-A3
- Plexin-A2
- Plexin-A4
- Plexin-B1
Sequence:
MKGACILAWLFSSLGVWRLARPETQDPAKCQRAEHPVVSYKEIGPWLREFRAENAVDFSRLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVQWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTIRSLSNLTEIHDQISGMARCPYSPQHNSTALLTASGELYAATAMDFPGRDPAIYRSLGTLPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGRDTLVHIIYLATDYGTIKKVRAPLSQSSGSCLLEEIELFPERKSEPIRSLKILHSQSVLFVGLQEHVVKIPLKRCHFHQTRGACIGAQDPYCGWDAVMKKCTSLEESLSMTQWDQSVPTCPTRNLTVDGSFGPWSPWTPCTHTDGTAVGSCLCRSRSCDSPAPQCGGWQCEGPRMEITNCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCENGPDCAGCNVEYQPCNTNACPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEFQECNILPCPVDGVWSCWSSWSKCSATCGGGHYMRTRSCTNPAPAYGGDICLGLHTEEALCNTQTCPENWSEWSEWSVCDASGTQVRTRQCILLFPVGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMMAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAALNSSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY
Protein: Glycophorin C (Gerbich blood group) (Glycophorin-C) (Q6XFR2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Protein 4.1
- Anion exchange protein
Sequence:
MDNQNAQTANRDSTRGPYFEAIVGVVITAVVLVLLLLLAIILRYMYQHKGTYHTNEAKGTEFAETADAALRRDPALQDAVDESKKEYFI
Protein: Complement factor properdin isoform 2 (A0A0S2Z515)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCAPACHPAQWLGAGGLGAL
Protein: Transcription factor MYB14 (Myb-related protein 14) (AtMYB14) (MYB14At) (Q9SJX8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that regulates freezing tolerance by affecting expression of CBF genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:24415840}.
Interaction partners:
- Transcription repressor MYB5
Sequence:
MGRAPCCEKMGVKRGPWTPEEDQILINYIHLYGHSNWRALPKHAGLLRCGKSCRLRWINYLRPDIKRGNFTPQEEQTIINLHESLGNRWSAIAAKLPGRTDNEIKNVWHTHLKKRLSKNLNNGGDTKDVNGINETTNEDKGSVIVDTASLQQFSNSITTFDISNDNKDDIMSYEDISALIDDSFWSDVISVDNSNKNEKKIEDWEGLIDRNSKKCSYSNSKLYNDDMEFWFDVFTSNRRIEEFSDIPEF
Protein: DOCK-like protein 1 (Q06409)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Forms a transiant heterodimeric complex with LMO1, that acts as a guanine nucleotide exchange factor exchange factor (GEF) for the small GTPase RHO5. DCK1, LMO1 and RHO5 relocate to mitochondria upon oxidative stress and trigger cell death. The DCK1/LMO1/RHO5 signaling module mediates mitochondrial turnover under nitrogen starvation conditions via mitophagy. The DCK1/LMO1/RHO5 signaling module plays also a function in cell wall integrity signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Mitochondrion {ECO:0000269|PubMed:25598154}. Note=Quickly relocates to mitochondria under oxidative stress. {ECO:0000269|PubMed:25598154}.
Interaction partners:
- ELMO family protein LMO1
- GTP-binding protein RHO5
- Cell division control protein 42
- GTP-binding protein RHO4
- GTP-binding protein RHO1
- GTP-binding protein RHO2
Sequence:
MSQQDSQRWLPTDRLIYGVLVKSFLPLQRYPELVYENSNYANVYVGAEVYVFEESVDKKWCRAYQCLRPFPEEFISNMNSANDVLPDVKPKVVIFPRKYVHFEAEKAVSTMPFFKAPSAEDFKPLISKECESRSFCDSLYVSSTDDISTGKPRKTPRPPFPFFRYQKRSFKDEMGPILSLISSHVYSMYSIGEFSIYRKMIKLYYDLDTIRFRLSMNLTTEAEKINLIRAATSLRTKIAKFLSSTYRKNKLIANSTPRNPDPYGFEGIFARDIDTGELLSYEIDKLRTLVSSSMLCGLTNNFPTVPVVESDDESSSNGLFGTVRSSILVNLKDLAWDPSISDPKYQDLSICVYLRTKDEVLTESFTMTKSSNMESALDEIPAMLFKNILETIVHKNKVYLVVVLKETIAITTETAPEISSYNISTEESSSHSPFSPFNSSTENKIDHVKKGLAAGVINISPVFKFYNGLSVANKAQRFNLYLYSSDSSDSQNFNSSKDADLGWGGLINKIIKDSSEGVSVNPRAVSLSVTVKEIIGKQEAEKVLSTSLVPIRSIPTYFYDTMFSQAERIYLNLGRVSLYGLPAADTNIENVTVQISCRNKAVKFCKNKLEERSGDWKFVSVRPNESIGESIRIEGVENMNEDETLRVLVYLNGFLMAKSNIHIKKKNEIIEYRKGTVFQIMSSKSVPLIHLELEASYFGRRYNINPAITNFLVLQTKNVEFDQQLKEHYSVTLKQLNNVSFKDLLKHFDTILAHYLLLLESVNEATDKKGPSSSLPNIVFSEFVKFLNLMLTHQENSRYWFNRLYKKVMSKELECPNVAPILIKHMTTIFDRSHSSWTRTGTAICRTILYIIVLAIGSSHSDEMPNFSHFFRSLHKFLMLADEPIMADQILLIESIPSMLETMTNHCKVEDLVRFAIGLFECCQEKEMNQKMYSRPLSVREEEYLNTKFNCLLKLINKKVLQNYLTNTESVDKLRLQFLSKTLEWLLTPYTPGDDKCFHVESLRLVNSVFITIIEDYKFDMLQRNLIRLLPYLCKSFVHLRRYCKKARLMRPRRVFTMLFPREIPCNYIPVDSIVNDEVVVEVLLELAIIICEITKIASSRFPSYQSFSEIINLCDKDTLFQSNFYSRQITNENVYTITKTVFLFFKQDWFPGMKWLGVSALLGRSSLILLSLCKDYIIENNSPSPSKESEKRVDMRLWAEYVKVILLVSNHKSASLTKLAITPRKAVYLISGDLKKISAYILNECWDALATGHYNITYAKKYGLGALSDCQFELFVHNQFLIREIFIFAFHRHIDATRICCKILWGLGLNFWRIFGSLQPAVNACIPELFSAYQIGKLRLNDYELERFVSCLFFMMHVPDSDTFFPACMDFLRDLLGFLHIVNEIYKIPNQEEFDDDRTARHIEMFEYLLEANRPELFHKMIYDLFIHFIQKKDFVQAALSLELLAGTYAWDSNDTLEAISFPPLPEQSSFERKEYLLKESARNFSRGQKPEKALAVYKDLIKAYDEINYDLNGLAFVHDQIAGIYTRLQSIDRLVPTYFKVSFMGFGFPKSLRNKSFVFEGLPFEHITSMHDRLLRSYHGSNIVHSQEEVDMLLMNPPMGKYIHVASVEPCLSISDNYNSSDKKSSINNKVRMYIENRDLRTFSNSRRLPGAKGVTDLWVEEYTYHTMNTFPTLMNRSEIVKVTKSKLSPLENAIRSLQVKIQELYGLENMCNKTLKDHGDVNDLFTELSTNITGTISAPVNGGISQYKAFLEPSTSKQFSTDDLGRLTLAFDELVAVLGRCLTLHAELLPSKDLKPSHDLLVRLFEENFAEEIERYSRTLSEANRSRNNMITARIISHKNPNKKASFSGRDHHTSGSNHSQFVLEHSDSFGPNSLLFGKYLTRTLSHSSTTSSLDKSGIVSGTSSTFLAGSQPNTNTDSQHKHDYSHSG
Protein: Probable LRR receptor-like serine/threonine-protein kinase At2g28960 (EC 2.7.11.1) (C0LGL4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Pentatricopeptide repeat-containing protein At5g06540
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- General transcription and DNA repair factor IIH subunit TFB2
- Putative disease resistance protein At4g19050
- Pentatricopeptide repeat-containing protein At5g42310, chloroplastic
Sequence:
MEGRRQRLLVFIFGALAITHLVQAQPPDQRGFISLDCGLPVNESPYTDPRTGLTFSSDADFILSGLRGEAGDDNTYIYRQYKDLRYFPDGIRNCYNLKVEQGINYLIRAGFGYGNYDGLNVYPKFDLHVGPNMWIAVDLEFGKDREIIYMTTSNLLQICLVKTGSTIPMISTLELRPLRNDSYLTQFGPLDLIYRRAYSSNSTGFIRYPDDIFDRKWDRYNEFETDVNTTLNVRSSSPFQVPEAVSRMGITPENASLPLRFYVSLDDDSDKVNVYFHFAEIQALRGNETREFDIELEEDIIQSAYSPTMLQSDTKYNLSPHKCSSGLCYLKLVRTPRSTLPPLISAIEAFKVVDFPYAETNPNDVAAMKDIEAFYGLKMISWQGDPCVPELLKWEDLKCSYTNKSTPPRIISLDLSSRGLKGVIAPAFQNLTELRKLDLSNNSFTGGVPEFLASMKSLSIINLNWNDLTGPLPKLLLDREKNGLKLTIQGNPKLCNDASCKNNNNQTYIVPVVASVASVLIIIAVLILILVFKKRRPTQVDSLPTVQHGLPNRPSIFTQTKRFTYSEVEALTDNFERVLGEGGFGVVYHGILNGTQPIAVKLLSQSSVQGYKEFKAEVELLLRVHHVNLVSLVGYCDEESNLALLYEYAPNGDLKQHLSGERGGSPLKWSSRLKIVVETAQGLEYLHTGCKPPMVHRDVKTTNILLDEHFQAKLADFGLSRSFPVGGETHVSTAVAGTPGYLDPEYYRTNRLNEKSDVYSFGIVLLEIITSRPVIQQTREKPHIAAWVGYMLTKGDIENVVDPRLNRDYEPTSVWKALEIAMSCVNPSSEKRPTMSQVTNELKQCLTLENSKRGVREDMGSRSSVEMSTSFTTEINPKAR
Protein: Doublecortin domain-containing protein 2 (Protein RU2S) (Q9UHG0)
Organism: Homo sapiens (Human)
Function: Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:27319779}. Cell projection, kinocilium {ECO:0000250|UniProtKB:D3ZR10}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:D3ZR10}. Note=Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner. {ECO:0000269|PubMed:25557784}.
Interaction partners:
- Dyslexia-associated protein KIAA0319
- Dynein axonemal assembly factor 4
- Acyl-coenzyme A thioesterase 13
- Kidney-associated antigen 1
- Tyrosyl-DNA phosphodiesterase 2
- Intron Large complex component GCFC2
- Calcium-transporting ATPase type 2C member 2
- Roundabout homolog 1
- Large ribosomal subunit protein bL19m
Sequence:
MSGSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA
Protein: Peptidyl-prolyl cis-trans isomerase CYP21-1 (PPIase CYP21-1) (EC 5.2.1.8) (Cyclophilin of 21 kDa 1) (Cyclophilin-21-1) (O49605)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase CYP21-3, mitochondrial
- Peptidyl-prolyl cis-trans isomerase CYP21-4
- UPF0235 protein At5g63440
- AT4g38690/F20M13_250
- Probable magnesium transporter NIPA6
- At4g34930
- AT4g34920/F11I11_160
- Dirigent protein 15
- Protein MANNAN SYNTHESIS-RELATED 1
- PEARLI 4 protein family protein)
Sequence:
MRREISFLLQPRCLLLLVALTIFLVFALFNTGKDEEKQVIEDHEITNRVFLDVDIDGQRLGRIVIGLYGTVVPKTVENFRALCTGEKGKTSSGKPLHYKGTPFHRIISGFVIQGGDIIHGDGKSSDSIYGGTFPDENFKIQHSHAGMVAMANTGPDSNGSQFFITTVKASWLEGEHVVLGKVIQGMDNVFAIEGGAGTYSGKPRKKVVIADSGEIPKDKWDEER
Protein: Uncharacterized protein C12B10.10 (Q10443)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Rho guanine nucleotide exchange factor gef2
- Mitosis inducer protein blt1
- Kinesin-like protein 8
- Anillin-related medial ring protein mid1
- Cell division control protein 15
- Rho1 guanine nucleotide exchange factor 3
Sequence:
MEKPLPNPPIQESLRKQSPQDAVYDDLVFGLKRYEAAFSIKDSIEDVLANFSKDEEKEMVCLSTSIAENPYQSLSLESVPSKILFGSFLFYVKDRIPEKAGYIIEEQFCKRLQQIDYDAYSFSPKECNEKLKNIFSEFSQMKLKMLSVFFSIVQILLPKLSGDYQEHVQFFASISAVVAPRGYVFEIYHAVEHLSLEAREVFQLHHPPSPKQTRRVVSEGPLNGVNYKQNTTNNRVSSFQNSQYSTLNNFQNNSNQSPNSNDLQPLQAEAFHSAHNGYSSSTLNLNSELNVMKDHDLQAPIPRALKQHKLPPIPVPEVQTTNIGYQTDLPLQNPNDNLVSLAIYEALYEKFLKACKDLEEVSKSYEESREEIEALHETFTEEVTSFQSTKRLKEEKIIQEKSRVDKMIDEYRQKLSEST
Protein: Cytochrome c oxidase assembly protein (Q57ZC2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Mitochondrial membrane-anchored protein domain-containing protein
- Ubiquinol-cytochrome c reductase complex 14 kDa protein
Sequence:
MAETRKEEWSEPEVPGGRSEVVAGIKRRREKLELYQSASHKMKALMMNSAGIRSGLGANNELPVNPIWMKFPTRCVKPIHSVEEMREKLHYFSHSDDVMVVRYHQENCTACNALDKTFEFLCHQSADRYPNLKFYEVSKDATPQLTRNLVRYPQVKGFSGGHWTDLEFKPPAEFREELYSGVEREVTRRKREGQPVTALEAEEMYYSSAGPAMAQVLEESVVKFYCKAQARLHNYWKQVSVRRAWFFRKFVEPKVDDQVRDEWRLKSVFGEKLSYGPEPQMEEF
Protein: Electron transporter, putative (DUF179) (Q8W467)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alanine-tRNA ligase, putative
- At1g32160/F3C3_6
- At4g33110
- At5g52960
- Pentatricopeptide repeat
- At1g63610
- ARM repeat superfamily protein
- Uncharacterized protein At3g49140
- UV-B-induced protein At3g17800
- MAR-binding filament-like protein
Sequence:
MDLWTLQLKDVTIRNPIFSSSIPEKSSSFSRKLCELEFRFLNRKVSASPYRSLVVRATSKKSNDDSSSPGDASQENKPSNGNKSGDSAAPKSFGLNTDWREFRANLFMKEQEEKAEAEGHESEPIGLKWAHPIPFPETGCVLVATEKLDGYRTFARTVVLLLRAGTRHPQEGPFGVVINRPLHKNIKHMKSTKTELATTFSECSLYFGGPLEASMFLLKTGDKTKIPGFEEVMPGLNFGTRNSLDEAAVLVKKGVLKPQEFRFFVGYAGWQLDQLREEIESDYWHVAACSSDLICGASSENLWEEILQLMGGQYSELSRKPKLDI
Protein: ECF RNA polymerase sigma factor SigJ (ECF sigma factor SigJ) (Alternative RNA polymerase sigma factor SigJ) (RNA polymerase sigma-J factor) (Sigma-J factor) (L0TCG5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity). Regulates the promoter of SigI, may not be autoregulated.
Interaction partners:
- HTH-type transcriptional regulator Rv1931c
- HTH hxlR-type domain-containing protein
- Probable transcriptional regulatory protein
- Probable ECF RNA polymerase sigma factor SigI
- Manganese transport regulator
- Transcriptional regulatory protein
- Uncharacterized HTH-type transcriptional regulator Rv0377
- Probable transcriptional regulatory protein
- Probable transcriptional regulatory protein
- RNA polymerase sigma factor SigF
Sequence:
MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAWLRWDSPDTVIADPRAWLTTVVSRLGLDKLRSAAHRRETYTGTWLPEPVVTGLDATDPLAAVVAAEDARFAAMVVLERLRPDQRVAFVLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALISGDPDPAHNEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKVVRFILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVRDGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
Protein: FI01029p (Q9W279)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein roadkill
Sequence:
MSISAVDRKEPGSVSSGLGRRYGQLLRGAKYTDCVFHVCEEQVKCHKLILSSASPVFEAMFFGPMQNNEPEPEIEIHDISSAIFKVLVEYIYTGVVDYNGLELVACIELYYAAEKYLLEELIADTLMVITRKLRFANILPALELSVCMGLDGLLEVCMTFFMRCCVNNGQYMSHLKEHYVHVSKECVKAIIAACKEPHKLLIWYVYEWTRQECEQLGLGPSDADLVVHDLGGKTSDWPAASGASDLESPALTPVVLVERCYYKACRPFTVDAETPLFRLRLKCSRFISLMGLVLNSRLTPNLLGHVQQLEYRESLRLDLCEVPAESEGPATSPVWSHVVQSQNTKYNCNLHLGWRREEACVLNPELTYELQIRWDSSAYGAEYPCSLQSCQADGIRFTDEDSFSGSLVKGLRYANLV
Protein: Zinc finger protein 45 (BRC1744) (Zinc finger protein 13) (Zinc finger protein KOX5) (Q02386)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus.
Interaction partners:
- Transcription intermediary factor 1-beta
- Zinc finger protein 17
- Zinc finger protein 227
Sequence:
MTKSKEAVTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNVVSVGHQSTPDGLPQLEREEKLWMMKMATQRDNSSGAKNLKEMETLQEVGLRYLPHEELFCSQIWQQITRELIKYQDSVVNIQRTGCQLEKRDDLHYKDEGFSNQSSHLQVHRVHTGEKPYKGEHCVKSFSWSSHLQINQRAHAGEKPYKCEKCDNAFRRFSSLQAHQRVHSRAKSYTNDASYRSFSQRSHLPHHQRVPTGENPYKYEECGRNVGKSSHCQAPLIVHTGEKPYKCEECGVGFSQRSYLQVHLKVHTGKKPYKCEECGKSFSWRSRLQAHERIHTGEKPYKCNACGKSFSYSSHLNIHCRIHTGEKPYKCEECGKGFSVGSHLQAHQISHTGEKPYKCEECGKGFCRASNLLDHQRGHTGEKPYQCDACGKGFSRSSDFNIHFRVHTGEKPYKCEECGKGFSQASNLLAHQRGHTGEKPYKCGTCGKGFSRSSDLNVHCRIHTGEKPYKCERCGKAFSQFSSLQVHQRVHTGEKPYQCAECGKGFSVGSQLQAHQRCHTGEKPYQCEECGKGFCRASNFLAHRGVHTGEKPYRCDVCGKRFRQRSYLQAHQRVHTGERPYKCEECGKVFSWSSYLQAHQRVHTGEKPYKCEECGKGFSWSSSLIIHQRVHADDEGDKDFPSSEDSHRKTR
Protein: DOMON related domain-containing protein (Q54RB8)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL3m
Sequence:
MKLLILIISLLISLSSCHIKQIILDEDTNFVVSWDYSNSNITFELEGDFKGWFAFGYRCTNCPANSMAMQMGHPDLVAVTFDSNGVPTVYDMIESMDYDPMQQKDIDIGGQSNILTFGGYQGSHHSLMYYTRKLVTGDTVGDYDIDLNADFSVTWYIGKDNKIDFDNPLELGTNNFNLVSGEVVEGGTGGHVHGAEELADPLFAWHAALMSIAFGVLIPFGIFSARYLKSYQWGFYLHIVIQSTALAFIIVGFVIILVKHDGVIETENPHSILGVILAAMVFAVGAFGVFCYFWKPKGDDGGSKQSNFSPSRIHGYAGKIIALLSVATIITGLRQYLAPVAFIIVYSILILTYFIIGGALEIHKRFYGSTPGGNVKMENFN
Protein: At1g56080 (Interactor of constitutive active ROPs protein) (Q0IGM5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g23760
- Nicotianamine synthase 3
Sequence:
MSQSGGDFNLSDEILAVIPTDPYDQLDLARKITSMAIASRVSNLESQVSGLRQKLLEKDRLVHELEDRVSSFERLYHEADSSLKNVVDENMKLTQERDSLAITAKKLGRDYAKLEAFKRQLMQSLNDDNPSQTETADVRMVPRGKDENSNGSYSNNEGLSEARQRQSMTPQFSPAFTPSGTPKILSTAASPRSYSAASSPKLFSGAASPTSSHYDIRMWSSTSQQSSVANSPPRSHSVSARHPRIDGKEFFRQARSRLSYEQFSAFLANIKELNARKQGREETLQKAEEIFGKENNDLYISFKGLLTSGR
Protein: ATP synthase subunit 5, mitochondrial (ATP synthase chain 5) (Oligomycin sensitivity conferral protein) (OSCP) (O74479)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
Subcellular location: Mitochondrion. Mitochondrion inner membrane.
Interaction partners:
- ATP synthase subunit gamma, mitochondrial
- ATP synthase subunit g, mitochondrial
- Putative ATP synthase subunit epsilon, mitochondrial
- ATP synthase subunit alpha
- ATP synthase subunit a
- ATP synthase subunit d
- ATP synthase subunit delta, mitochondrial
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit 4
- ATP synthase subunit 9, mitochondrial
Sequence:
MNHIFRRSIPITARLPSLGIRSLATATASAHPPVQLYGLDGSYASSLYTAAVKESKLDNVEKALNKLSGVLQQRPEFEQYISSPWLTREDKKILVSSLTQMTGNEPLLKNFYNVLLDNHRLYLLTRIQKQFSTLMRAKRGEIEVKITSATPLDSKILSRLESRIAKSKYGKGKLLVSNKVTPSIIGGLIVEIGDNILDVSVGSRLNNLNKLLSEPI
Protein: Acyl dehydratase (P96398)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MASGYGGIRVGGPYFDDLSKGQVFDWAPGVTLSLGLAAAHQSIVGNRLRLALDSDLCAAVTGMPGPLAHPGLVCDVAIGQSTLATQRVKANLFYRGLRFHRFPAVGDTLYTRTEVVGLRANSPKPGRAPTGLAGLRMTTIDRTDRLVLDFYRCAMLPASPDWKPGAVPGDDLSRIGADAPAPAADPTAHWDGAVFRKRVPGPHFDAGIAGAVLHSTADLVSGAPELARLTLNIAATHHDWRVSGRRLVYGGHTIGLALAQATRLLPNLATVLDWESCDHTAPVHEGDTLYSELHIESAQAHADGGVLGLRSLVYAVSDSASEPDRQVLDWRFSALQF
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (O24435)
Organism: Oryza sativa (Rice)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MISLPLLLFVLFFSALLLFPSSSDDDGGGDAAGDELALLSFKSSLLYQGGQSLASWNTSGHGQHCTWVGVVCGRRHPHRVVKLRLRSSNLAGIISPSLGNLSFLRTLQLSDNHLSGKIPQELSRLSRLQQLVLNFNSLSGEIPAALGNLTSLSVLELTNNTLSGAIPSSLGKLTGLTDLALAENTLSGSIPSSFGQLRRLSFLSLAFNNLSGAIPDPIWNISSLTIFEVISNKLSGTLPTNAFSNLPSLQEVYMYYNQFHGRIPASIGNASNISIFTIGLNSFSGVVPPEIGRMRNLQRLELPETLSEAEETNDWKFMTALTNCSNLQEVELGGCKFGGVLPDSVSNLSSSLVSLSIRDNKISGSLPRDIGNLVNLQYLSLANNSLTGSLPSSFSKLKNLRRLTVDNNKLIGSLPLTIGNLTQLTNMEVQFNAFGGTIPSTLGNLTKLFQINLGHNNFIGQIPIEIFSIPALSEILDVSHNNLEGSIPKEIGKLKNIVEFHADSNKLSGENPSTIGECQLLQHLFLQNNFLNGSIPIALTQLKGLDTLDLSGNNLSGQIPMSLGDMPLLHSLNLSFNSFHGEVPTNGVFANASEIYIQGNAHICGGIPELHLPTCSLKSRKKKKHQILLLVVVICLVSTLAVFSLLYMLLTCHKRRKKEVPATTSMQGHPMITYKQLVKATDGFSSSHLLGSGSFGSVYKGEFDSQDGEITSLVAVRVLKLETPKALKSFTAECETLRNTRHRNLVKIVTICSSIDNRGNDFKAIVYDFMPNGSLEDWLHPETNDQAEQRHLTLHQRVSRRNFYPKFQTLTCV
Protein: Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] (P54886)
Organism: Homo sapiens (Human)
Function: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:26297558, ECO:0000269|PubMed:26320891}. Mitochondrion matrix {ECO:0000269|PubMed:32770108}. Note=Exhibits puncta-like structures inside mitochondria under nutrient stress (PubMed:32770108). When cellular dependence on oxidative phosphorylation increases, forms filaments, which may increase its activity, and is sequestered in a subset of atypical mitochondria that lack cristae and ATP synthase (PubMed:39506109). {ECO:0000269|PubMed:32770108, ECO:0000269|PubMed:39506109}.
Interaction partners:
- Ornithine aminotransferase, mitochondrial
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Glutamate dehydrogenase 1, mitochondrial
- Pyrroline-5-carboxylate reductase 1, mitochondrial
- Glutamate dehydrogenase 2, mitochondrial
- Glutaminase kidney isoform, mitochondrial
- Glutaminase liver isoform, mitochondrial
- Glutamine synthetase
- Pyrroline-5-carboxylate reductase 3
- Asparagine synthetase
Sequence:
MLSQVYRCGFQPFNQHLLPWVKCTTVFRSHCIQPSVIRHVRSWSNIPFITVPLSRTHGKSFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNQLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGMGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEILLANKKDLEEAEGRLAAPLLKRLSLSTSKLNSLAIGLRQIAASSQDSVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAVQLVNTREEVEDLCRLDKMIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLELCIEVVDNVQDAIDHIHKYGSSHTDVIVTEDENTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGKDHVVSDFSEHGSLKYLHENLPIPQRNTN
Protein: Cystein proteinase inhibitor protein salarin (Cathepsin M) (Q70SU8)
Organism: Salmo salar (Atlantic salmon)
Function: Inhibits papain and ficin (cysteine proteinases) but not trypsin (a serine proteinase).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12397376}. Vacuole {ECO:0000269|PubMed:12397376}.
Interaction partners:
Sequence:
MKSLVLLLLVAVTVSSVVSKPLPEDSEAEVHKEFETWKVKYGKSYPSTEEEAKRKEMWLATRKKVMEHNTRAGNGLESYTMAVNHLADLTTEEVPKGLLPMPRPEEEEVDKEFEMWKTHNGKTYNSTEEEAKRKEIWLATRARVMEHNKRAENGSESFTMGINYFSDMTFEEIPKARLMVVFPTRDGGEEAEVDKEFETWKVQHGKNYGSTEEEAKRKGIWLATRTRVMEHNKRAETGSESFTMGMNHLSDKTTAEVTGRRLQDGEEAEVHKEFETWKVKYGKTYPSTVEEAKRKEIWLATRKMVMEHNKRAENGLESFTMGVNHFADLTAEEVPRGLFPME
Protein: Transcriptional regulator CtsR (Q2G0P8)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region.
Interaction partners:
- Protein-arginine kinase activator protein
- Protein-arginine kinase
- ATP-dependent Clp protease ATP-binding subunit ClpC
- Chaperone protein ClpB
- Heat-inducible transcription repressor HrcA
Sequence:
MHNMSDIIEQYIKRLFEESNEDVVEIQRANIAQRFDCVPSQLNYVIKTRFTNEHGYEIESKRGGGGYIRITKIENKDATGYINHLLQLIGPSISQQQAYYIIDGLLDKMLINEREAKMIQAVIDRETLSMDMVSRDIIRANILKRLLPVINYY
Protein: 45 kDa calcium-binding protein (Stromal cell-derived factor 4) (A0A5F9UJX7)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus lumen {ECO:0000256|ARBA:ARBA00023769}.
Interaction partners:
Sequence:
MASRWGPLIGLAPCCLWLLGAVLLMDASARPANHSSTRERVANREENEILPPDHLNGVKLEMDGHLNRGFHQEVFLGKDLGGFDEDAEPRRSRRKLMVIFSKVDVNTDRKISAKEMQRWIMEKTAEHFQEAMEESKTHFRAVDPDGDGHVSWDEYKVKFLASKGHSEKEVADAIRLNEELKVDEETQEVLENLKDRWYQADSPPADLLLTEEEFLSFLHPEHSRGMLRFMVKEIVRDLDQDGDKQLSVPEFISLPVGTVENQQGQDIDDNWVKDRKKEFEELIDSNHDGIVTAEELENVPTLPLQPIGTLNSHFVRLAAELGGGKATLTCAPLARRATWTP