Protein: Polycystin-2 (CePc2) (Polycystic kidney disease 2 protein homolog) (Q9U1S7)
Organism: Caenorhabditis elegans
Function: Functions as a calcium permeable cation channel. Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as lov-1 and atp-2 in response behavior.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11553327, ECO:0000269|PubMed:12411744, ECO:0000269|PubMed:15563610, ECO:0000269|PubMed:15753033, ECO:0000269|PubMed:16481400, ECO:0000269|PubMed:16943275, ECO:0000269|PubMed:17581863, ECO:0000269|PubMed:18037411}; Multi-pass membrane protein {ECO:0000269|PubMed:11553327, ECO:0000269|PubMed:12411744, ECO:0000269|PubMed:15563610, ECO:0000269|PubMed:15753033, ECO:0000269|PubMed:16481400, ECO:0000269|PubMed:16943275, ECO:0000269|PubMed:17581863, ECO:0000269|PubMed:18037411}. Cell projection, cilium membrane {ECO:0000269|PubMed:11553327, ECO:0000269|PubMed:12411744, ECO:0000269|PubMed:15563610, ECO:0000269|PubMed:15753033, ECO:0000269|PubMed:16481400, ECO:0000269|PubMed:16943275, ECO:0000269|PubMed:17581863, ECO:0000269|PubMed:18037411}. Cell projection, cilium {ECO:0000269|PubMed:11553327, ECO:0000269|PubMed:12411744, ECO:0000269|PubMed:15563610, ECO:0000269|PubMed:15753033, ECO:0000269|PubMed:16481400, ECO:0000269|PubMed:16943275, ECO:0000269|PubMed:17581863, ECO:0000269|PubMed:18037411, ECO:0000269|PubMed:26150102, ECO:0000269|PubMed:28745435}. Cell projection, axon {ECO:0000269|PubMed:11553327, ECO:0000269|PubMed:12411744, ECO:0000269|PubMed:15563610, ECO:0000269|PubMed:15753033, ECO:0000269|PubMed:16481400, ECO:0000269|PubMed:16943275, ECO:0000269|PubMed:17581863, ECO:0000269|PubMed:18037411}. Cell projection, dendrite {ECO:0000269|PubMed:11553327, ECO:0000269|PubMed:12411744, ECO:0000269|PubMed:15563610, ECO:0000269|PubMed:15753033, ECO:0000269|PubMed:16481400, ECO:0000269|PubMed:16943275, ECO:0000269|PubMed:17581863, ECO:0000269|PubMed:18037411}. Perikaryon {ECO:0000269|PubMed:11553327, ECO:0000269|PubMed:12411744, ECO:0000269|PubMed:15563610, ECO:0000269|PubMed:15753033, ECO:0000269|PubMed:16481400, ECO:0000269|PubMed:16943275, ECO:0000269|PubMed:17581863, ECO:0000269|PubMed:18037411}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11553327, ECO:0000269|PubMed:12411744, ECO:0000269|PubMed:15563610, ECO:0000269|PubMed:15753033, ECO:0000269|PubMed:16481400, ECO:0000269|PubMed:16943275, ECO:0000269|PubMed:17581863, ECO:0000269|PubMed:18037411}. Note=Synthesized in the endoplasmic reticulum, and then packaged into vesicles that are transported to the ciliary base and inserted into the ciliary membrane. Localizes to both the ciliary base and cilium proper. {ECO:0000269|PubMed:11553327, ECO:0000269|PubMed:12411744, ECO:0000269|PubMed:15563610, ECO:0000269|PubMed:15753033, ECO:0000269|PubMed:16481400, ECO:0000269|PubMed:16943275, ECO:0000269|PubMed:17581863, ECO:0000269|PubMed:18037411}.
Interaction partners:
- Location of vulva defective 1
- Intraflagellar transport protein 20 homolog
- Exocyst complex component 5
- Kinesin-like protein
- Nephrocystin-1-like protein
- NePHronoPhthisis
- BBSome complex member bbs-5
- Rab8
- Tetratricopeptide repeat protein 21 homolog
- CILiary localization
Sequence:
MNYGAADERWANPPQPVAAAEHGPSFDHSMVSEEYEHDKKKNPAQKEGISFSQALLASGHEKSDGKIKLTARSFMEVGGYAVFLIVLVYVAFAQNSIQSYYYSKVMSDLFVASTGASGAPAFGSCTSMDNIWDWLSQVLIPGIYWTETSNSTDNENMIYYENRLLGEPRIRMLKVTNDSCTVMKSFQREIKECFANYEEKLEDKTMVGDGSVDAFIYATAKELENLKTVGTIASYGGGGFVQRLPVAGSTEAQSAIATLKANRWIDRGSRAIIVDFALYNANINLFCVVKLLFELPASGGVITTPKLMTYDLLTYQTSGGTRMMIFEGIFCGFILYFIFEELFAIGRHRLHYLTQFWNLVDVVLLGFSVATIILSVNRTKTGVNRVNSVIENGLTNAPFDDVTSSENSYLNIKACVVFVAWVKVFKFISVNKTMSQLSSTLTRSAKDIGGFAVMFAVFFFAFAQFGYLCFGTQIADYSNLYNSAFALLRLILGDFNFSALESCNRFFGPAFFIAYVFFVSFILLNMFLAIINDSYVEVKAELARKKDGEGILDWFMNKVRGLTKRGKRPDAPGEDATYEDYKLMLYRAGYAEKDINEAFTRFNVTSMTEHVPEKVAEDIADEVARMTEQKRNYMENHRDYANLNRRVDQMQESVFSIVDRIEGVNATLQTIEKQRVQQQDGGNLMDLSALLTNQVRNRESAARRPTITSIADKKEE