wanglab/gogpt-training-data huggingface dataset:
Protein: Catenin beta 1 (A0A2R8Y7Z0)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}.
Interaction partners:
Sequence:
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL
Protein: Cation transporter HKT1;5 (OsHKT1;5) (Cation transporter HKT8) (OsHKT8) (Q0JNB6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Sodium transporter that under salt stress mediates sodium exclusion in the phloem to prevent sodium transfer to young leaf blades and reproductive tissues.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28488420}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the plasma membrane. {ECO:0000269|PubMed:28488420}.
Interaction partners:
- Os04g0643100 protein
- Probable V-type proton ATPase subunit d
- V-type proton ATPase subunit F
- Vacuolar proton pump subunit B
- Vacuolar proton pump subunit B
Sequence:
MSSLDATTPRYDEFKRIYHLFLFHAHPFWLQLLYFLFISLLGFLMLKALPMKTSMVPRPMDLDLIFTSVSATTVSSMVAVEMESFSNSQLLLITLLMLLGGEVFTSILGLYFTNAKYSSKMIATLPDDDDHGGSGKPPPPTTSPSSTLVELELAPPMDVVVVNPTTTATTHDEVELGLGRRNKRGCTCTTTHTSSSSSASKTTTTRLLMFVVMGYHAVVHVAGYTAIVVYLSAVGGAGAVVAGKGISAHTFAIFTVVSTFANCGFVPTNEGMVSFRSFPGLLLLVMPHVLLGNTLFPVFLRLAIAALERVTGWPELGELLIRRRRGGGEGYHHLLPSSRTRFLALTVAVLVVAQLALFCAMEWGSDGLRGLTAGQKLVGALFMAVNSRHSGEMVLDLSTVSSAVVVLYVVMMYLPPYTTFVPVQDKHQQTGAQSGQEGSSSSSIWQKLLMSPLSCLAIFIVVICITERRQIADDPINYSVLNIVVEVISAYGNVGFSTGYSCARQVRPDGSCRDLWVGFSGKWSKQGKLTLMAVMFYGRLKKFSLHGGQAWKIE
Protein: Anthracycline acyl carrier protein DpsG (Q9ZAU0)
Organism: Streptomyces peucetius
Function: Involved in the biosynthesis of aklanonate which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers.
Interaction partners:
Sequence:
MAELSLAELREIMRQSLGEDEVPDLADADTVTFEDLGLDSLAVLETVNHIERTYGVKLPEEELAEVRTPHSMLIFVNERLRAAA
Protein: ATP-dependent Clp protease ATP-binding subunit ClpX (P9WPB9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-D factor RsdA when present in a complex with ClpP1 and ClpP2. Does not seem to act on anti-sigma-L factor RslA.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit 1
- ATP-dependent Clp protease proteolytic subunit 2
- Uncharacterized MFS-type transporter Rv2456c
- ATP-dependent zinc metalloprotease FtsH
- ATP-dependent Clp protease ATP-binding subunit ClpC1
- Cell division protein FtsZ
- LexA repressor
- Co-chaperonin GroES
- ATP synthase subunit beta
- Probable molybdenum cofactor guanylyltransferase
Sequence:
MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELADADDVKLDELPKPAEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGEKGRDSRCEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVAGAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFADVMPEDLIKFGLIPEFIGRLPVVASVTNLDKESLVKILSEPKNALVKQYIRLFEMDGVELEFTDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTKETVQDNVLPTIVPRKPSRSERRDKSA
Protein: Vacuolar protein-sorting-associated protein 60 (Charged multivesicular body protein 5) (Q03390)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has a role in a late stage of multivesicular body (MVB) formation. Can stimulate VPS4 ATPase activity via VTA1.
Subcellular location: Endosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Interaction partners:
- Vacuolar protein sorting-associated protein VTA1
- Vacuolar protein sorting-associated protein IST1
- Vacuolar protein-sorting-associated protein 46
- Vacuolar-sorting protein SNF7
- DOA4-independent degradation protein 4
- Vacuolar protein-sorting-associated protein 24
- Vacuolar protein sorting-associated protein 20
- Vacuolar protein sorting-associated protein 4
- Uncharacterized protein YJL049W
- Vacuolar protein-sorting-associated protein 25
Sequence:
MNRIFGYGNKKSHDQLLQESNQSMNQAQQSLSNRISQLDTQIAQLNFQLQNIQKNLQRSNNKQPSLRKQALKILNKRKQLENMKDSLDSQSWSMTQAQLTNDNLQNTMITINALKQTNNAMKAQYGKINIDKLQDMQDEMLDLIEQGDELQEVLAMNNNSGELDDISDAELDAELDALAQEDFTLPTSENSLGNDMPSYLLGANAPPAFIDEEPNLDTEDKNKALESAQ
Protein: Alkylglycerone-phosphate synthase (Alkyl-DHAP synthase) (EC 2.5.1.26) (B7Z3Q4)
Organism: Homo sapiens (Human)
Subcellular location: Peroxisome {ECO:0000256|RuleBase:RU363113}.
Interaction partners:
Sequence:
MKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSDTPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNIYGNIEDLVVHIKMVTPRGIIEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIKIRPVPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNKQFQFGHALKPQVSSIFTSFLDGLKKFYITKFKGFDPNQLSVATLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGYLLTYVIAYIRDLALEYYVLGESFETSAPWDRVVDLCRNVKERITRECKEKGVQFAPFSTCRVTQTYDAGACIYFYFAFNYRGISDPLTVFEQTEAAAREEILANGGSLSHHHGVGKLRKQWLKESISDVGFGMLKSVKEYVDPNNIFGNRNLL
Protein: Kinesin-like protein (A0A0G2JW74)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSGTEEDLCHHMKVVVRVRPENTKEKAVQFHKVVHVVDKHILVFDPKQEEISFFHRKKTTNFDITKRQNKDLKFVFDAVFDETSTQMEVFEHTTKPILHSFLNGYNCTVFAYGATGSGKTHTMLGSTAEPGVMYLTMLDLFKCMDEVKDEKECSTAVSYLEVYNEQIRDLLTNSGPLAVREDAQKGVVVQGLTLHQPKSSEEILQLLDNGNKNRTQHPTDMNAASSRSHAVFQIYLRQQDKTASINQNVHIAKMSLIDLAGSERASISGTKGTRFVEGTNINKSLLALGNVINALADTKRRNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSLFYDDTYNTLKYANRAKDIKSSQLKSNVVNLSSHISQYVKICNMQKAEILMLKEKLKAYEGQKALTDRNDCAKLVHSNVEDKEIERFQEILNCLFQNREGMRQEYLKVEMLLKENELKSSYHQQCHKQIEMMCSEDKLEKATCRRDHRLEKLKSNRCVLEKKKEEMLKQFDENTNWLHRVESEMRLLGQNGDIPEGLNKDLHCHHLHLQNKDLKTQMGHMMTLAALQEQQHGQTEAVLNALLPVLRKQYWRLKETGLSNAAFDSDFKDIEHLVERKKVVAWADQTAEHSNQSDVPGTSLLMTFPQLGPIQSIPCCSSMSDPSILKITPQRRTKRKLIPSPLKVKHTQKSALSERTQLNDSFSKELQPIVYTPEDSRRTVQDLSPPLARASSHSANGMNDNSLKALCRTESPLSRTECKEGLYSTSAICDGIKSLKNNLPEPLPSSKSTLHRVESSSFPTKDSRSVSTSVPSYMAMTTAAKRKWKFMSSTSDASLKSDESCGLAKRIRQDNSSVKLIRENRLRVGYKKTTNKTNSNMLRKFRRNTSKENVQ
Protein: Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase] (P09172)
Organism: Homo sapiens (Human)
Function: Conversion of dopamine to noradrenaline.
Subcellular location: [Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000269|PubMed:7961964}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000269|PubMed:7961964}. Secreted {ECO:0000269|PubMed:7961964, ECO:0000269|PubMed:8546710}.; SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:7961964}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000269|PubMed:7961964}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Phenylethanolamine N-methyltransferase
- Amine oxidase [flavin-containing] A
- Amine oxidase [flavin-containing] B
- Aromatic-L-amino-acid decarboxylase
- Catechol O-methyltransferase
- Tyrosine 3-monooxygenase
- Transmembrane O-methyltransferase
- Amine oxidase [copper-containing] 3
- Amine oxidase [copper-containing] 2
- Paired mesoderm homeobox protein 2A
Sequence:
MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQGRSPAGPTVVSIGGGKG
Protein: Outer-membrane lipoprotein carrier protein (Q9I0M4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
Subcellular location: Periplasm {ECO:0000255|HAMAP-Rule:MF_00240}.
Interaction partners:
- Lipoprotein-releasing system ATP-binding protein LolD
- Outer-membrane lipoprotein LolB
- Outer membrane protein assembly factor BamD
- Lipoprotein signal peptidase
- Outer membrane protein assembly factor BamA
- LPS-assembly protein LptD
- Lipoprotein-releasing ABC transporter permease subunit
- Apolipoprotein N-acyltransferase
- Lipoprotein-releasing ABC transporter permease subunit
- Replication-associated recombination protein A
Sequence:
MRLIRTLFVAALAMGASLAHADDSAAVQRLTGLLNKAQTLTARFSQLTLDGSGTRLQETAGQLSLKRPGLFRWHTDAPNEQLLISNGEKVWLYDPDLEQVTIQKLDQRLTQTPALLLSGDISKISESFAITYKEGGNVVDFVLKPKTKDTLFDTLRLSFRSGKVNDMQMIDGVGQRTNILFFDVKMNEALDAKQFTFDVPPGVDVIQE
Protein: Serine/threonine-protein kinase Haspin homolog ALK1 (EC 2.7.11.1) (DNA damage-responsive protein ALK1) (P43633)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Serine/threonine haspin-like protein kinase involved in cell cycle regulation.
Interaction partners:
Sequence:
MLLHFDIVIQLLSSHTLKSHQVEPPMDFETSFEEFVEDKRFIALEVSDNDDDCDTDLTADTADELESSAILKMRESDASLNVTTGNNTSRKTTSNSKKRWSLLSNHSAVSSSKSKKRWSVLSSSFTSESHKDRESRNVLQQKRKSLQSYSSLDTVASNSSISASSSLKRSSTGLSLRQLFTKIGINDDISQPGIGIPQGKENLPPTMGKKNSSIASTSSENRLRTPLKPLVNHSKRPTSQPQQQQPLYNASLSSRRSSISSTVSSSSSSKWRFWKRNKNQTPALLQPDHHSLKTFPAVNRRDSMTPVEPRNMVKHKTSFSDFHKTIFSSNTYSESSDTISSMEITLKNKASSSSLSLNVLKKRNSQSSLKHKSSHASLQKFKRNKGKSSMIAPSTATNSSNDDSCSYSSKNSTLSHRISLPVPDQVSRDKIQNKLRYSTSLLSLNSKSSLPMNKNDHDETLLRQILLNCDIKRILNPAKGDVLPLINDVNHLSSIQLTSNVWQIGEVICKKVSLGTIDDITWDRKFLSLQELEKLKIMQQKFDGIPQLLKSFVVKEANGGLYLYLLFKDHGTPISLISLKNWKQILKIFWSCAGIIHGLEKNLKFEHRNLTLDNILIDGNGNITIIDFKCSRLQTPQDDVLYLRLDHPLFFLNGKDKSKINEYQYQFEFEIYQSMRILLNMDASAFEPMTNLYWLYYLSRVLLKFGDRKLGKNDANRDKMARVINHLEMNLAVHKRGGQLFKRLETEDIKNTGDLLKLYK
Protein: cellulase (EC 3.2.1.4) (Endo-beta-1,4-mannanase F) (Q4X1L7)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Probable endo-beta-1,4-glucanase celB
- Glucanase
- Probable 1,4-beta-D-glucan cellobiohydrolase C
- cellulase
- cellulase
- Extracellular endoglucanase, putative
- Endoglucanase, putative
- beta-glucosidase
- Probable 1,4-beta-D-glucan cellobiohydrolase A
- Probable beta-glucosidase A
Sequence:
MRISSLIMAASAAGLVSALPVREMTKKRSSGFTWVGINESGAEFGSNIPGKLGTDYTWPDTSKIQTLRDAGMNIFRVPFLMERLVPSSITGNLDATYLSDLKKTVEFITGSGAYAVLDPHNYGRYSGSIISSTSDFQEFWKTVASEFASNDKVIFDTNNEYHDMDQTLVLNLNQAAINGIRAAGATTQYIFVEGNHYSGAWTWADNNDNLKGLKDPEDKIVFEMHQYLDSDGSGTSESCVSSTIGQERVESATQWLKDNSLKGFLGEFAGGVNSQCETAVEGLLSYMSENSDVWLGAEWWSAGPMWGNYMYSLEPSTGPAYSSYLPILKNYFVSGTSSSSSSSSSITSSTTSVNNPTTSATTQAQVVNTSSSSPTPSPTSVPAAEAPAPTPTEAAKTSSAASTTPTTAAASTTASACRAPEPADETTLPSATPTTSASASGIAKHWYQCGGINWTGPTTCESGYTCVEQNPYYHQCV
Protein: Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (P56432)
Organism: Sus scrofa (Pig)
Function: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity). Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter (By similarity). Interacts with FOSB to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 site of FASLG/CD95L, and activating its transcription in T cells upon stimulation by TCR/CD3 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P05412}.
Interaction partners:
Sequence:
MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGNLKPHLRAQDSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVSGAGLVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQQPPQPPHHLPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Protein: Defective proboscis extension response 13, isoform C (A0A0B4LFL9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPASSGLYRIKNGRVLDRLQKPAALIFIIAYIAACGICDHTASASPGGGKTVAATMTTPASEPSVRHINQNLIMSQSKEGEPVPVPQPYAQSAASAGGSSITSFDSTNVIDGQSQPTPTHLQEAVLQTHSHSRIQAKDTAGPYPIPVHRPEPVENHLEANNGIEGGMESLFGTPMYFGTENSTVVTTQIGATAHVPCTVHHIGEGVVSWIRKKDYHLLTVGLTTYSSDERFSATHLKHSEDWTLQIKFVQLRDAGVYECQVSTHPPTSIFLHLSVVARAEITGPPIRYLTPGSTLRLQCRVVQNTEASEYIFWYHDNRMINYDIDRGINVSTEPDFQSSELTIQRTRREHSGNFTCVASNTQPASVLVHIFKGDNPAAMYHGHVGGSTKTTQSQLHMIMIIIASGYRIFHTSVYMKIV
Protein: Ras-related protein Rab-5A (Q86JP3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Required for the fusion of plasma membranes and early endosomes.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Interaction partners:
- Phosphatidylinositol 3-kinase VPS34-like
- 7-fold repeat in clathrin and VPS proteins repeat-containing protein
Sequence:
MNNNNKIFQFKLVLLGEAAVGKSSLVLRFVRGHFLDYQESTIGAAFLAQTVCLNDTTVKFEIWDTAGQERYHTLAPMYYRGAQAAIVVYDIRSEDSFERAIKWVKELQRQGSPNIVIALAGNKLDLAAKRKVETAEAQQYAEENGLLFMETSAKTSQNVNELFVEIAKKLPKTPTTRPGSGRVAIAPIDNGNTGKKNKCCN
Protein: Core gene UL23 family protein (ORF 21) (ORF21) (Thymidine kinase) (Q98143)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MAEGGFGADSVGRGGEKASVTRGGRWDLGSSDDESSTSTTSTDMDDLPEERKPLTGKSVKTSYIYDVPTVPTSKPWHLMHDNSLYATPRFPPRPLIRHPSEKGSIFASRLSATDDDSGDYAPMDRFAFQSPRVCGRPPLPPPNHPPPATRPADASMGDVGWADLQGLKRTPKGFLKTSTKGGSLKARGRDVGDRLRDGGFAFSPRGVKSAIGQNIKSWLGIGESSATAVPVTTQLMVPVHLIRTPVTVDYRNVYLLYLEGVMGVGKSTLVNAVCGILPQERVTSFPEPMVYWTRAFTDCYKEISHLMKSGKAGDPLTSAKIYSCQNKFSLPFRTNATAILRMMQPWNVGGGSGRGTHWCVFDRHLLSPAVVFPLMHLKHGRLSFDHFFQLLSIFRATEGDVVAILTLSSAESLRRVRARGRKNDGTVEQNYIRELAWAYHAVYCSWIMLQYITVEQMVQLCVQTTNIPEICFRSVRLAHKEETLKNLHEQSMLPMITGVLDPVRHHPVVIELCFCFFTELRKLQFIVADADKFHDDVCGLWTEIYRQILSNPAIKPRAINWPALESQSKAVNHLEETCRV
Protein: Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha) (Q9UJU2)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Note=Found in nuclear bodies upon PIASG binding. {ECO:0000250}.
Interaction partners:
- Hepatocyte nuclear factor 4-alpha
- Mothers against decapentaplegic homolog 4
- Catenin beta-1
- Serine/threonine-protein kinase NLK
- Four and a half LIM domains protein 2
- Histone acetyltransferase p300
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 3
- Junction plakoglobin
- Histone deacetylase 1
Sequence:
MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNMNNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWQGQPVYPITGGFRQPYPSSLSVDTSMSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI
Protein: Fras1-like extracellular matrix protein 1a (D7PS89)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MTVKTSKCVCFFLLGLIQLIRGSLVKTNAVLKVKRGQSVFLQEDDLQFRIPRVKDSCKLEVVLNEPITQRVGSLTPQVFDCHFMADEVKYTHNGCPILKEDTVKLRLYRFTETETYSELFSLRVEILEPECNVIQFGSQQLVVPEFYGLSNVLDGNVVSFNYEHRHNIECTIRVTGLETHLPVHGQLVTGEPEKADGPRGDEPDSFVSLRRQLDNKARAHCKTDDCLKGLKLLKITKVPCNDFLMMGIRYQHTDPPSPHTDYISIRLDLTDTRSRSIIQSEQAWIPVTITGALPNQPPKPAFMSMFILEVDQFILTPLSTATVDAEDDETPKQRLVFNITKPPSEGFITHLSDHTKPVSSFSWTDLNGMLISFQPPNSSATHRRNYEVEFEVHDFYFEKSQPVTVHVSIRTADTNAPRVSWNMGLSLLEGQSRPITWDQLQIVDNDNLKAVKIITVDGLQHGRLTVRGGKGFMFTVNDIKSGVVHYHHDDSDTTKDYIVFRITDGLHQTRHKFPINILPKDDSPPFLITNMLLELSEGQTALLRGSILQACDMDSSDDYIMFNVTRAPQAGEIMKMPGPGITGYPVNRFLQKDLFHSIIYYRHSGREVFDDSFEVVLSDFHDPPNLSEPQVIVIQIQPVPDQPPQEAPGVSRHLVINETDVVYLTKQQLHFVDLESPDSELTYTVTTPPFYTTTYGGSDAGRLFLVDSIPKFSKDSSAPMLRLFTQHAVNYMKVAYMPPIPDIGPYPQHIQFVLSVTNQQGSTTTGICFNVTVLPVDNQAPEVQVKLLVVDEGGEIWVTEDHMHLSDRDSLQDSIHVELKTAPQHGSVYLDGKLMVPGQTFTVRDLKSLKVRYRHDSSETERDEIKFIATDGTNTADFILRIKVTLVNDEVPVLVAGLKPMLWCAEGQEVFITIEYICATDPDSDDRSLMYMIARQPYHGVVQRNGIIVDRFIQADLNAGFISYRHTGQEIGLRPRHDVVTFVISDGETEPISPCCSERDTLFNPQNSLPVYDLNITVYPVNNQPPSIATGEVFMVDEGGSASITVTHLTXVDQDSAPEDLQLILVSPPHFGYIENILPSPGFEKSNVGISIASFTYRDVLDGHINYVQSRHQRMEPTTDQLMLQVSDGKQQSSPVPLYIIISPTNDEIPDFQTQNITVFEGDRTELNSSVISAVDLDVPQERLMFSIVQNPQHGSIISLPHRNQVSHYKRGAEEPVQHFCMDDLKSGMTLMYVHDDSESEQDEFILQLSDGKHKLQKHVQVKILPVNDEEPQIIRNTGIEMEAGESRLISSAVLSAHDEDTPPDHILYVFESLPTHGAIQMKVGSDWLSVSAGVNCSQKVLDMNLLRYLHTAHPGEPTADFFVFHLFDGKNRSPPQHFHITVKQLEKGDIALFLKPVRVSRGDRVVFTTDVLLXVDGADQPEELLYVITAPPAHGHVELIKHSGVQIQSFSQLDIAANLVCYVHDNRATAPRESLQFMVSNGISTRNGTLEILVDLTDKVLPTLVHNSGLRVPQGSTVVLSTAVLSLSDPDSPASTLSYRLIQTPQYGQLLLKGQALVAGAHFTQQDLQDLDVTYKHSGGASQIDRFTFTASDSTDRGFLLDGRVQTEPVFFTLQIEALDSSAPQVAVLETLWKVELLKDGRYGIFISSRELKAEDTNTADADLTFHILRAPYIGYLENHTSGEFVRQRFSQMDLNRRNILYVINSALDALSDSLEFAVSDALGNTGLSHKLNFSWAGVELTRTQYTVCESQGSVSLTIQRKGNMQDSSYVTVQVKELTASAGKDFIPASSLIQFDPGVASRVWKVEIVQDSLEEADEKFEVSLASPVAAVLKDNSRATISIKDSNGQCVERQITAGSSLQGREVRPGPYPQHGSIQLETLPLSPEGVIRGDGDTTDQAPAAPKKRLRVTGNGKVVQPSETIRRGSELIYKYHGLVSMAVEEDESASRTDRQAEVQVNSRGQQQRLLTVQTKPQQTSRHTSSRLLQRTHTQTSSKRCSPDLSGLLHYNQSSGRLFRCNGDSWRPWTPTNETVKAQRCPQGWTYHSNNCYLLSSERKASWSTAARACRERFSGHLVSVQSKAHMAWLWDFSQRKPFWIGLHDGESRGRWEWMDGQSVTYTNWRRNPPKNQKKKETRRCVLVWKKSRWQIRDCQRGKGHRYVCYTQLH
Protein: Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (Malonate-semialdehyde dehydrogenase [acylating]) (Q7JMI1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLSRLARVQPKCQQLAHFSTSKSAAAAPTVKLWIDGQAVESKTTDFVELTNPATNEVIAMVPNATQAEMQAAVDSAKNAFNTWKNTSFQIPTDPSTMHVQTSSLDQERHEEAR
Protein: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Q12983)
Organism: Homo sapiens (Human)
Function: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Subcellular location: Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
Interaction partners:
- Apoptosis regulator Bcl-2
- Gamma-aminobutyric acid receptor-associated protein
- Bcl-2-like protein 1
- GTP-binding protein Rheb
- Gamma-aminobutyric acid receptor-associated protein-like 2
- GABA type A receptor associated protein like 1
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
- Beclin-1
- Peptidyl-prolyl cis-trans isomerase D
- FUN14 domain-containing protein 1
Sequence:
MSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF
Protein: GH26867p (Q95T36)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIASLDSLKL
Protein: C-8 sterol isomerase, putative (Q582S0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Interaction partners:
- Lanosterol 14-alpha-demethylase
- Squalene monooxygenase
- NAD
- Lathosterol oxidase, putative
- Methyltransferase
- Delta
- C-5 sterol desaturase, putative
Sequence:
MGLCKTLFVFLLTVTLAGFVHLVNRPENWVFDPKELQTIVKQSISNARSKYGDNPSADAVIAEVIEGVLATYPAHTTNSSRWMWNNAGGAMGSMKLLHASFSEYIIIFGTAVGTEGHTGRYHLAEDFFTIIHGEQWAALPNSTVPEVYKPGDQHYLPKHTAKQYKMPGPCFALEYARGVIPSMFFFGFADMFSSTLDMVTLYHTVVESTKQMIPNALRGKI