wanglab/gogpt-training-data huggingface dataset:
Protein: ATP-dependent Clp protease proteolytic subunit (O97252)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- ATP-dependent protease subunit ClpQ
- ATP-dependent protease ATPase subunit ClpY
- Heat shock protein 101
- Chaperone protein ClpB1
- Clp
- ATP-dependent Clp protease regulatory subunit ClpC
Sequence:
MIYLFLFLFLILLKNKKIQTKKSIKNSNILTFIPLSKKNEIVKENIGKLLTYNLQYDQGYTNYNKKVRKINVHNSSSEFANNINLDIEKQNNERAILKKEDLNFQIKNDCISKDNINKKKIKNMHNKDQGMIQHTNTNDNIDYTNSNYNNYLNYDVKKKKNKKRKYSKVQQQIITNNDDIKDMKKDVKLFFFKKRIIYLTDEINKKTADELISQLLYLDNINHNDIKIYINSPGGSINEGLAILDIFNYIKSDIQTISFGLVASMASVILASGKKGKRKSLPNCRIMIHQPLGNAFGHPQDIEIQTKEILYLKKLLYHYLSSFTNQTVETIEKDSDRDYYMNALEAKQYGIIDEVIETKLPHPYFNKVEK
Protein: VWFD domain-containing protein (Q8C5Q6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
ARGPADMGSPWKWWALWAGATLLWALLTPAEASCQGIQCASGQRCQMVSGKARCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCSYTMAELCGSDETLPAFSVEAKNEHRGSRQVSYVGLVTVYAYSHSVSLVRGEIGFVRIDNQRSRLPASLSEGRLRVHKSGTRGVIEMDFGLVVTYDWDGQLTLSLPKRFQDQVCGLCGNYNGDPADDFLTPDLDQAPDALEFANSWKLDDGDYLCDDGCHNSCPSCTPGQTQHYKGDRLCGMLTLSTGPFSACHEFLDPKPFLDDCVFDLCVTGGERLSLCRSLSAYAQACVELGVTLENWRLPASCRK
Protein: Neurotrophic tyrosine kinase receptor type 3a (G9JKB3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MDLFSIPPRVCLWRILFLLSIFQDYMSSMLDCPPTCTCSTTDIFCNKSYQGNFFPLLALQDTVSDGNTTNSLPDLFENISTIHIENWSLQTLKDLDMELYTGLQRLNIVNCNLRTIQSRAFAKNPHLRYINLSRNPLTTLSWQLFQNLQLLELKLEGVVFNCSCNIRWIQLWQQRGEAGLHNQQLFCFNGYSKIPLQLMNISQCDFPEISVSHSNLTVTEGDRVMITCNGSGIPVPEVDWTVGGLHSINTHQANQYPPNVHSINLTLVNVSRDDNGFMLTCIAENIVGMTNASIQLSVQFPPAIINFEEPQKRHDTCMMFTVRANPLPTLHWSFKGEEIKATEYVHPEMEVYQDNLEGCLLFKNPTQHNNGNYTLEARNYLGVAVKTVYAHFLHPPFEDYPDYVSPTPTAIPTTTHRPEEDTFGVSIAVGLAGFACVLLVVMFVLINKYGRRSKFGMKGPVAVIGGEEDSASPLHHVNHGIITPCTLDAGPDAVVIGMTRIPVIENPQYFRHGHNCNKPATYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKTLKDPTLAARK
Protein: Phenazine N-monooxygenase PhzNO1 (EC 1.14.-.-) (Baeyer-Villiger-like flavin enzyme) (Cyclohexanone monooxygenase) (NADPH-dependent flavin-containing N-monooxygenase) (A0A172J1R7)
Organism: Lysobacter antibioticus
Function: Involved in the biosynthesis of phenazine natural products including myxin, an N(5),N(10)-dioxide phenazine antiobiotic, which has antimicrobial activity. Catalyzes the aromatic N-oxidations of phenazines, such as 1,6-dihydroxyphenazine (DHP), 1,6-dihydroxyphenazine N(5)-oxide (DHPO) and 1-hydroxy-6-methoxyphenazine to produce DHPO, iodinin (1,6-dihydroxyphenazine N(5),N(10)-dioxide) and 1-hydroxy-6-methoxyphenazine N(10)-oxide, respectively. Catalyzes also the N-oxidation of 8-hydroxyquinoline, but not 6-hydroxyquinoline (6-HQ), quinoline, quinoxaline, quinine and 2-phenylpyridine.
Interaction partners:
Sequence:
MIDNDKTHFDAIVIGTGFAGIYMLHKLRNELGLKVRAFDKASGVGGTWYWNKYPGARADTESFVYRYSFDKETSEGWDWRNRYVDQPEMLGYLQAVVDRHGLAKDIQLKTGIDSAVFDEIHHIWTLTTSTGELFTARYLVNAVGVLSKIVIPQIPGRDKFQGQIVHTGAWPADLSLEGKRVGVIGTGSTGVQFICAASKLARHLTVFQRSAQFCVPAGSRQVSEAYVAEYKNNFEQIWDGIRNSRIACGFEESGVSAMSVSEEERQKVFEHHWEIGNGFRFMFGTFSDIAVDPAANQAASDFIRAKIRQIVKDPETARKLCPTDLYAKRPVCTNDYYETYNLPNVSLVSLPENPIKELTANGVLTEDGVEHKLDLLVFATGFETVEGSYNQMEIRGRGGETLQHHWKDAPSSYLGVATAGFPNMFMVLGPNSAFSNLPPSIESQVEWIGELIGWAEGESTPVIETTREAEEAWTATCKEIAAYTLFPKVKSWIFGENIDGRSSRVLFYFGGLAGYRAKLREVADADYEGFILHSDPSSMVA
Protein: Protocadherin-8 (Activity-regulated cadherin-like protein) (Arcadlin) (D3ZE55)
Organism: Rattus norvegicus (Rat)
Function: Calcium-dependent cell-adhesion protein. May play a role in activity-induced synaptic reorganization underlying long term memory. Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:10383464}. Presynaptic cell membrane {ECO:0000269|PubMed:10383464}. Postsynaptic cell membrane {ECO:0000269|PubMed:10383464}. Note=Also expressed in the cell bodies of neurons of the hippocampus and cortex. Localized to excitatory, but not with inhibitory, synapses.
Interaction partners:
Sequence:
MSPVKRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQSPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQASYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFGARTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGPGPRTATCKVIVRIRDVNDNAPDISITPLAAPGAPATSPFAAAAAAAALGGADAASSAGSGTQETGVTSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTKPVYEVSVRENNPPGAYLATVAARDPDLGRNGQVTYRLVEAEVGRSGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQASDGGSPQLSSNALVQVRVLDQNDHSPVLVHPAPANGSLEVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIVLTGDLSQEPPGRVFKALLVISDGGRPPLTTTATVSFVVTAGGGSAVPASAGSPEHFRPPGSRLAPSGPSLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPDETARGTGPRPNMFDVLTFPGSGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYSASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCAGPNTHPPPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYESPPGGRYVSPKKGTNENV
Protein: Protein MIZU-KUSSEI 1 (O22227)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in lateral root development by maintaining auxin levels. This function requires GNOM (GN/MIZ2) activity. Negatively regulates cytokinin sensitivity on root development. Positively regulates hydrotropism in roots.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22285304}. Note=Soluble protein associated with the ER.
Interaction partners:
- E3 SUMO-protein ligase SIZ1
- E3 SUMO-protein ligase MMS21
- E4 SUMO-protein ligase PIAL1
- ARF guanine-nucleotide exchange factor GNOM
- Small ubiquitin-related modifier 1
- SUMO-conjugating enzyme SCE1
- Small ubiquitin-related modifier 2
- DNA ligase 6
- E4 SUMO-protein ligase PIAL2
- Small ubiquitin-related modifier 5
Sequence:
MVPYQELTLQRSFSYNSRKINPVTSPARSSHVRSPSSSALIPSIPEHELFLVPCRRCSYVPLSSSSSASHNIGKFHLKFSLLLRSFINIINIPACKMLSLPSPPSSSSSVSNQLISLVTGGSSSLGRRVTGTLYGHKRGHVTFSVQYNQRSDPVLLLDLAMSTATLVKEMSSGLVRIALECEKRHRSGTKLFQEPKWTMYCNGRKCGYAVSRGGACTDTDWRVLNTVSRVTVGAGVIPTPKTIDDVSGVGSGTELGELLYMRGKFERVVGSRDSEAFYMMNPDKNGGPELSIFLLRI
Protein: Probable NAD-dependent epimerase/dehydratase WbpK (Q9HZ81)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Glycosyltransferase WbpL
- Probable glycosyl transferase WbpJ
- Nucleotide sugar epimerase/dehydratase WbpM
- UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronate 2-epimerase
- UDP-N-acetyl-D-glucosamine 6-dehydrogenase
- Probable glycosyltransferase WbpH
- UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase
- LPS biosynthesis protein WbpG
- UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase
- UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase
Sequence:
MVTGASGFVGSALCCELARTGYAVIAVVRRVVERIPSVTYIEADLTDPATFAGEFPTVDCIIHLAGRAHILTDKVADPLAAFREVNRDATVRLATRALEAGVKRFVFVSSIGVNGNSTRQQAFNEDSPAGPHAPYAISKYEAEQELGTLLRGKGMELVVVRPPLIYANDAPGNFGRLLKLVASGLPLPLDGVRNARSLVSRRNIVGFLSLCAEHPDAAGELFLVADGEDVSIAQMIEALSRGMGRRPALFTFPAVLLKLVMCLLGKASMHEQLCGSLQVDASKARRLLGWVPVETIGAGLQAAGREYILRQRERRK
Protein: Rifin (Q8I3E2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKIHYTNILLFPLKLNILVNTHKKPHTTARHTQKIPTTRSLSECELYAPVNYYSDPQMKEVMDNFNKQTQQRFHEYDERMKTTRQKCKDRCDKEIQKIILKDKLEKELTEKFATLQTDIQSDAIPTCICEKSLADKVEKGCLRCAQNLGGVAPGWGLLSGFDYVTWSQYISGIAAKAAADAGLKAGVKVGLVNVVKIVRNTLGSAGEVPPMDWEKLIIFGNFSDGVTLHAIFKNLDNMMNGYLDSRKYSQFSMVVQKFAGNFKPITAKYSKEVAEVTKAVADAKTGVLTKAGNATSSLSTGITASIIAIVVIVLIMVIIYLVLRYRRKKKMKKKLQYIKLLEE
Protein: Spi-1 proto-oncogene (F5H3K6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLQACKMEGFPLVPPPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVHSEFESFAENNFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHPSLGHQVSYLPRMCLQYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGETGGAPGPPPWPRPWPCLCPAPTQPGQLTQQPRHRVACVCVCMFASVCVLWGCLWLSLCVCICCVVHTGISMKCARCVCLSVP
Protein: T-cell surface glycoprotein CD8 alpha chain (CD8 antigen 32 kDa chain) (OX-8 membrane antigen) (CD antigen CD8a) (P07725)
Organism: Rattus norvegicus (Rat)
Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P01732}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01732}. Note=CD8A localizes to lipid rafts only when associated with its partner CD8B. {ECO:0000250|UniProtKB:P01732}.
Interaction partners:
- T-cell surface glycoprotein CD8 beta chain
- Beta-2-microglobulin
- T-cell surface glycoprotein CD4
- Proto-oncogene tyrosine-protein kinase LCK
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface glycoprotein CD3 zeta chain
- Tyrosine-protein kinase
- T-cell surface glycoprotein CD3 delta chain
- RT1 class Ia, locus A1
- RT1 class I histocompatibility antigen, AA alpha chain
Sequence:
MASRVICFLSLNLLLLDVITRLQVSGQLQLSPKKVDAEIGQEVKLTCEVLRDTSQGCSWLFRNSSSELLQPTFIIYVSSSRSKLNDILDPNLFSARKENNKYILTLSKFSTKNQGYYFCSITSNSVMYFSPLVPVFQKVNSIITKPVTRAPTPVPPPTGTPRPLRPEACRPGASGSVEGMGLGFACDIYIWAPLAGICAVLLLSLVITLICCHRNRRRVCKCPRPLVKPRPSEKFV
Protein: Desmocollin-1 (Desmosomal glycoprotein 2/3) (DG2/DG3) (Q01107)
Organism: Bos taurus (Bovine)
Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q08554}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, desmosome {ECO:0000250|UniProtKB:P55849}.
Interaction partners:
- Desmoglein-1
- Corneodesmosin
- Junction plakoglobin
- Plakophilin-1
- Desmoplakin
- Plakophilin-3
- Plakophilin 2.
- Desmoglein 3
Sequence:
MAVASAAPGSIFWKQLLFSLLVLILFCDACQKISLQVPSHLRAEALVGKVNLKECLQSASLILSSDPDFRILEDGSIYTTHDLVLSSGKSFSILLSDSQGQGQKEIEIILEAGGKKVPKRHMKDAVLRRTKRRWAPIPCSLMENSLGPFPQHVQQVQSDAAQNYTIFYSISGPGVDKEPFNLFFIEKDTGDIFCTRSIDREQYQEFPIYAYATTADGYAPEYPLPLVFKVEDDNDNAPYFENKLTVFTVPENCRTGTSVGKVTAIDLDEPDTLHTRLKYKILQQIPNNPRHFTVHPDTGVITTTTPLLDREKCDTYKLIMEVRDMGGQPFGLFNTGTITISLEDENDNAPYFTETSYTVEVEENRIDVEILRMAVHDHDLPNTPHSRAVYQILQGNENGTFKISTDPNTNEAVLCVVKPLNYEVNRQVVLQIGVLNEAQFAKAVNSKTTTTMCTTVVTVKVKDHDEGPECQPPVKVIQSEDCLPTGTELLGYKAVDPERGTGEGLRYKKIQDEDNWFEINEYTGDLKTVKVLDRESTFVKNNQYNVSVIAFDADGRSCTGTLVVFLEDKNDHPPQIKQEELTICRHDKDYVVLEPTDQDGPDNGPPFQFILDNSASKLWTVETRDGKTAILRGRQDLDYDYYTVPIQIKDRHGASATHILPVRVCDCTIPSECRMPSKLSREAALANVFLGKWAILAMVLGSVLLLCILFTCFCVTVKKTVKKCFPEDVAQQNLIVSNTEGPGEEVMDANIRLPTQTSNVCDTSISVGTLGGQGVKTQQSFEMVKGGYTLDANKGGGHQTLESVKGVTDTGRYTYSDWHNFTQPRLGEKVYLCGQDEEHKLCEDYVRSYSYEGKGSVAGSVGCCSDRQEEEGLDFLDHLEPKFRTLAKTCVKK
Protein: Golgin family A protein (F4JPI4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Aminotransferase-like, plant mobile domain family protein
- Aminotransferase-like, plant mobile domain family protein
- Aminotransferase-like, plant mobile domain family protein
- Aminotransferase-like, plant mobile domain family protein
- Aminotransferase-like, mobile domain protein
- Aminotransferase-like, plant mobile domain family protein
- Serine/threonine-protein phosphatase 7 long form-like protein
- Plant mobile domain protein family
Sequence:
MAFFKLLLFLFLVTLQIASFTGNGEASSSSSENNGCNGDQNHLLNELKSTVSALQSIIKEKNQELLSKEEKIRGLELYIREKPYLFESEIDFSQFENPVKHASEVEEKVYELQKQVFGLKREVETQRKRRLEVEAELADKKVAQLSSKLENIDGWFLSKLGLNPTESQAYLMTLWHQHLSPTLHTTLQMVSMKIEQVQKWSEPHIETLNSQWIPSIKDACVTITIYLEPKVQYITDKSIELLYTSKQALTPHLIQGFDASYYYLEVIRTHTHPYTTRIMTLTKPHLERVQVALEPYTENVRHGFQKLVNSTKIYHQQAQEMLKNNEITKPVATMDLAWVGATALIGFPLIFIIKLLSAVSNPKGKKRHNHKKEPTTGYRRAKRRHPHQ
Protein: Solute carrier family 22 member 12 (Renal-specific transporter) (RST) (Urate anion exchanger 1) (URAT1) (Urate:anion antiporter SLC22A12) (Q8CFZ5)
Organism: Mus musculus (Mouse)
Function: Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (By similarity). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:14747372}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Solute carrier family 2, facilitated glucose transporter member 9
- Sodium-dependent phosphate transport protein 1
- Solute carrier family 17
- Uricase
- Broad substrate specificity ATP-binding cassette transporter ABCG2
Sequence:
MAFPELLDRVGGLGRFQLFQTVALVTPILWVTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIPGDLGPDVLLAVSIPPGPDQQPHQCLRFRQPQWQLTESNATATNWSDAATEPCEDGWVYDHSTFRSTIVTTWDLVCNSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTAAAFMPTFPLYCLFRFLLASAVAGVMMNTASLLMEWTSAQGSPLVMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGKLDQGLQELQRVAAVNRRKAEGDTLTMEVLRSAMEEEPSRDKAGASLGTLLHTPGLRHRTIISMLCWFAFGFTFYGLALDLQALGSNIFLLQALIGIVDFPVKTGSLLLISRLGRRFCQVSFLVLPGLCILSNILVPHGMGVLRSALAVLGLGCLGGAFTCITIFSSELFPTVIRMTAVGLCQVAARGGAMLGPLVRLLGVYGSWMPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQDIQKQSVKKVTHDTPDGSILMSTRL
Protein: TPR_REGION domain-containing protein (Q18426)
Organism: Caenorhabditis elegans
Interaction partners:
- Peroxisomal membrane protein PEX14
- Peroxisomal membrane protein PEX13
- Peroxisome assembly protein 12
- Peroxisomal ATPase PEX1
- Peroxisomal biogenesis factor 3
- Peroxisomal ATPase PEX1
- 2-hydroxyacyl-CoA lyase
- Peroxisomal biogenesis factor 11
- Non-specific lipid-transfer protein-like 2
- Putative peroxisomal biogenesis factor 19
Sequence:
MKGVVEGQCGQQNALVGLANTFGTSNQRVAPSNAAASLLPSSSMGEQMANEFLRQQARTMAPTSFSMKSMQNNLPQASASSSLAANWTKEFQPRQNQLASQWSQQYTSSAPSMESAWRQVQAPSMTSTSSHQPITDAGMWSSEYLDTVDTSLTKSSGTQNWADDFMEQQDNYGMENTWKDAQAFEQRWEEIKRDMEKDESLQSPENYVYQEANPFTTMSDPLMEGDNLMRNGDIGNAMLAYEAAVQKDPQDARAWCKLGLAHAENEKDQLAMQAFQKCLQIDAGNKEALLGLSVSQANEGMENEALHQLDKWMSSYLGSNSTQVTTTPPLYSSFLDSDTFNRVEARFLDAARQQGATPDPDLQNALGVLYNLNRNFARAVDSLKLAISKNPTDARLWNRLGATLANGDHTAEAISAYREALKLYPTYVRARYNLGISCMQLSSYDEALKHFLSALELQKGGNDASGIWTTMRSAAIRTSNVPDNLLRAVERRDLAAVKASLV
Protein: Ribosome assembly protein METTL17, mitochondrial (False p73 target gene protein) (Methyltransferase 11 domain-containing protein 1) (Methyltransferase-like protein 17) (Protein RSM22 homolog, mitochondrial) (Q9H7H0)
Organism: Homo sapiens (Human)
Function: Probable S-adenosyl-L-methionine-dependent RNA methyltransferase required to stabilize the mitochondrial small ribosomal subunit (mt-SSU). Required for protein translation in mitochondria.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q3U2U7}.
Interaction partners:
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS9m
Sequence:
MAAALKCLLTLGRWCPGLGVAPQARALAALVPGVTQVDNKSGFLQKRPHRQHPGILKLPHVRLPQALANGAQLLLLGSAGPTMENQVQTLTSYLWSRHLPVEPEELQRRARHLEKKFLENPDLSQTEEKLRGAVLHALRKTTYHWQELSYTEGLSLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGQSLREYMCVDRSAAMLVLAEKLLKGGSESGEPYIPGVFFRQFLPVSPKVQFDVVVSAFSLSELPSKADRTEVVQTLWRKTGHFLVLVENGTKAGHSLLMDARDLVLKGKEKSPLDPRPGFVFAPCPHELPCPQLTNLACSFSQAYHPIPFSWNKKPKEEKFSMVILARGSPEEAHRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVLTARRHGRDLYRCARVSSWGDLLPVLTPSAFPPSTAQDPSES
Protein: NAD(P)-binding Rossmann-fold superfamily protein (F4IKL5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDKRWSLQGMTALVTGAASGIGYAIVEELAGFGARIHVCDISETLLNQSLREWEKKGFQVSGSVCDVTSRPEREKLMQTVSSLFDGKLNILVNNVGVLRAKPTTEYVADDFTFHISTNLEAAYHFCQLSHPLLKTSGYGSIVFLSSVSGVVSITDCGSLYGLTKGALNQLARNLACEWAKDGIRANAVAPNVVKTAQSQFFLQDVSKKEGLFSRTPLGRSGEPNEVASLVVFLCLPAASYITGQTICIDGGLTYYFICLVKLSFSNYCNLCVYIWINVISTRWNQR
Protein: MICOS complex subunit MIC60 (Altered inheritance of mitochondria protein 28) (Formation of crista junctions protein 1) (Found in mitochondrial proteome protein 13) (Mitofilin) (P36112)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:19528297, ECO:0000269|PubMed:21944719, ECO:0000269|PubMed:21987634}; Single-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:19528297, ECO:0000269|PubMed:21944719, ECO:0000269|PubMed:21987634}. Note=Enriched at crista junctions.
Interaction partners:
- MICOS complex subunit MIC12
- MICOS complex subunit MIC19
- MICOS complex subunit MIC10
- MICOS complex subunit MIC27
- MICOS subunit MIC26
- Sorting assembly machinery 50 kDa subunit
- Mitochondrial import receptor subunit TOM40
- Mitochondrial import receptor subunit TOM22
- Mitochondrial import receptor subunit TOM20
- Mitochondrial import receptor subunit TOM70
Sequence:
MMLRTTASRKIVLRRGLASINTGTTVASKKASHKFRNTLWTIALSATAFYAGGIIYSQKNDKFGDFFSNNVPFAEDLLETYEHYHDRPTLFLEDSWDGLKAKSNDLLSGLTGSSQTRRSNRENIEVKKILSLEPLNIETENSDPQLKEIIGSLNDLINSLNDSNLSIPESEFNSIKKSNQNMLTNLSQLNETLKEALSNYMIQRTSEVITELNTQYENSKREFEKNLQKNLLQEVDEFKENLTKQKDKELEEKLKANEELLQAKHANEVGLLSITQVKEFNKIIKDKIEKERNGRLAHLEEINSEVNDLSKSIDRSSKILSKNEALVQLTFQVDEIKSRINNNNLPDVNIDKELSRLKLLSNLLSTFNKKSCCDDGDCCSCKKGNKNEGKEGKISCKCKPKTNPPSLLSVALDELESTCSGKKILSNEQIYNRWNLLADDFKTASLLPPNSGILGQLTAKVFSLFLFTKTGNPSNATDFDSVYARVGDNLRVSNLNDAVEEVVSLKGWPHKVCESWIEDARRKLEVQRLVEILDCEIRTL
Protein: Choline O-acetyltransferase (EC 2.3.1.6) (F1P393)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MPDLEKDMQKKEKDSRSKDEPAVPKLPVPPLQQTLQMYLQCMKHLVPEEQFRKTKSIVEQFGVAGGLGESLQLILEERREKTTNWVFNYWLDDMYLNNRLALPVNSSPAIIFARQNFKDVNDQLRFAANLISGVQDYKALLDSHALPVDFARGQLSGQPLCMKQYYGLFSSYRLPGHTKDTLVAQKSCVMPEPEHIIVACNNQFFVLDVVINFRRLSEGDLFTQLRKIAKMAENEEEMLPPIGLLTTDGRTEWAEARTILMKDSTNRDSLDMIERCICLVCLDGTSGVELNDTNMALQLLHGGGYHKNGANRWYDKPMQFVVGRDGVCGTVCEHSPFDGIVLVQCTEHLLKHMKESSKKLLRADSVSELPAPRRLRWKCSPEIQAHLASSAEKLQRIVKNLDFIAYKFVNYGKEFIKKQKTSPDAYIQVALQLAFYRCHRRLVPTYESASIRRFDEGRVDNIRSATAEAFAFVKAMIDDKPALSDSEKMQRFKDAIAAQTNYTILAITGMAIDNHLLGLREVAREHFKELPEIFTDETYLTSNRFILSTSQVPTTMEMFCCYGPVVPNGYGACYNPQPEHILFCISSFKDCKETSSDMLAKAVEESLLEIRDLCNKCSSSTAKSLAKQEEATQLRSDHKL
Protein: D(1A) dopamine receptor (Dopamine D1 receptor) (Q7LZ75)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell projection, cilium membrane {ECO:0000256|ARBA:ARBA00004272}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004272}.
Interaction partners:
Sequence:
MTWNDTTMDGEGLLVERDSSFRILTGCFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVSEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFIMISVAWTLSVLISFIPVQLNWHKATTTSFLDLNASLQGISMDNCDSSLNRMYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQNTSGNRSSMDCQQPESNFKMSFKRETKVLKTLSVIMGVFVCCWLPFFVLNCMIPFCEPTQPSKGAEAFCINSTTFDVFIWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPMSGNAIETVSINNNGAVFSSQHEPKGSSPKESNLVYLIPHAIICPEEEPLKKEEEGELSKTLEKMSPALSGMLDYEADVSLEKITPITQNGQHKT
Protein: Alkaline protease secretion ATP-binding protein AprD (Q03024)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Involved in the secretion of alkaline protease.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Alkaline protease secretion protein AprE
- Alkaline protease secretion protein AprF
- Serralysin
- Uncharacterized protein
- Proteinase inhibitor
- Transport protein HasD
- Membrane fusion protein
- Methionine import ATP-binding protein MetN 2
Sequence:
MARLGSSVTNEIKQALAASRGALRSVAAFSGVINLLMLVPSLYMLQVYDRVLSSANEVTLLMLTLMALGVFVFMGALEALRSFVLVRVSERFDGQLHGRIYAAAFERNLRAGGQEASQALHDLTTLRQFITGQALFAFFDAPWFPVYLLVIFLFDPWLGLLSLVGALALMALAWFNERATRAPLAKAGELSIKSGQLASNNLRNAEVIEAMGMLGSMRGRWERLHQAFLDQQSLASERAARINALSKYLRIALQSLVLGLGAWLAVEGRITPGMMIAGSILMGRALGPIDQLIGVWKQWGAARDAYRRLSGLLDEFPARERRMELPEPRGHLLLESLDAAPPGSEARTLRGLTLAIPAGSVVGVIGPSGSGKSSLARVVLGIWPTLHGSVRLDGAEIRQYERETLGPRIGYLPQDIELFAGTVAENIARFGEVQADKVVEAARLAGVHELVLRLPQGYDTVLGVGGAGLSGGQRQRIALARALYGAPTLVVLDEPNSNLDDSGEQALLAAIQALKARGCTVLLITHRAGVLGCADRLLALNAGQLHLYGERDQVLAALNNQRAASASQQRADYRVAGYGAPQVVAAPRQGGVE
Protein: Receptor expression-enhancing protein 6 (Polyposis locus protein 1-like 1) (TB2 protein-like 1) (Q9JM62)
Organism: Mus musculus (Mouse)
Function: Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24098485, ECO:0000269|PubMed:28475715}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:28369466}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sorting nexin-15
Sequence:
MDGLRQRFERFLEQKNVATEALGALEARTGVEKRYLAAGALALLGLYLLFGYGASLLCNVIGFVYPAYASVKAIESPSKEDDTVWLTYWVVYALFGLVEFFSDLLLFWFPFYYAGKCAFLLFCMTPGPWNGALLLYHRVIRPLFLKHHMALDSAASQLSGRALDLAAGITRDVLQALARGRALVTPASTSEPPAALELDPK