wanglab/gogpt-training-data huggingface dataset:
Protein: Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) (O95997)
Organism: Homo sapiens (Human)
Function: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Separin
- Cell division cycle protein 20 homolog
- Fizzy-related protein homolog
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-B1
- Ubiquitin-conjugating enzyme E2 C
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Cell division cycle protein 27 homolog
- G2/mitotic-specific cyclin-B2
- Aurora kinase A
Sequence:
MATLIYVDKENGEPGTRVVAKDGLKLGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNRATEKSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMILDEERELEKLFQLGPPSPVKMPSPPWESNLLQSPSSILSTLDVELPPVCCDIDI
Protein: Brain-derived neurotrophic factor (proBDNF) (Q4JHT7)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU364086}.
Interaction partners:
- Tyrosine-protein kinase receptor
- Neurotrophin-3
- Tyrosine-protein kinase receptor
- Vascular endothelial growth factor receptor 2
- Parvalbumin
- Glial cell derived neurotrophic factor.
- Doublecortin
- Tyrosine-protein kinase receptor
- Ciliary neurotrophic factor
- Alpha-synuclein
Sequence:
MTILFFTMVISYFTCMKAAPMKEASLRGQGSLAYPGLRTHGTIESINGPSASSRGLTSLADTFEHVIEELLDEEQDIQPSEGNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCNPKGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDNKKRVGWRFIRIDTSCVCTLTIKRGR
Protein: Delta 6 desaturase (I3NL78)
Organism: Sparus aurata (Gilthead sea bream)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGGGGQLTEPGEPGSRRAGGVYTWEEVQSHSSRDDQWLVIDRKVYNVTKWAKRHPGGFRVINHYAGEDATEAFTAFHPDLKFVRKFLKPLLIGELAATEPSQDRNKNAAVIRDFHTLRVQAESDGLFRAQPLFFCLHLGHILLLEALAWLIIWLWGTSWTLTFLISIILATAQAQAGWLQHDFGHLSVFKKSSWNHILHKFVIGHLKGASANWWNHRHFQHHAKPNIFSKDPDVNMLHIFVLGDTQPVEYGIKKIKYLPYHHQHQYFLLVGPPLLIPVYFHIQIIRTMISRHDWVDLAWSMSYYLRYLCCYVPLYGLFGSVALISFVRFLESHWFVWVTQMNHLPMDIDHEKHHDWLTMQLQATCNIEKSVFNDWFSGHLNFQIEHHLFPTMPRHNYHLVAPLVHALCEKHGIPYQVKTMWQGIVDVIRSLKNSGDLWLDAYLHK
Protein: Chitin-binding protein 3 (Mo-CBP3) (P86528)
Organism: Moringa oleifera (Horseradish tree) (Moringa pterygosperma)
Function: Chitin-binding protein. Has antifungal activity against F.solani, F.oxysporum, C.musae and C.gloesporoides but not against P.oligandrum. Depending on concentration the antifungal activity can be fungistatic or fungicidal. Inhibits both spore germination and mycelial growth in F.solani at a concentration of 0.1 mg/ml. Has antifungal activity against C.krusei, C.albicans, C.tropicalis and C.parapsilosis. Has no chitinase, beta-glucanase or hemagglutinating activity. Acts as a flocculent.
Interaction partners:
Sequence:
CPAIQRCCQQLRNIQPPCRCCQ
Protein: Nicotinamide mononucleotide adenylyltransferase (NMN adenylyltransferase) (NMNAT) (EC 2.7.7.1) (NMN-specific adenylyltransferase) (Promoter of filamentation protein 1) (P25576)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Involved in the salvage pathway for NAD(+) biosynthesis via NMN. Involved in the filamentation pathway. Suppresses the filamentation defect of a KSS1 deletion.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24759102}. Nucleus {ECO:0000269|PubMed:24759102}.
Interaction partners:
- Glutamine-dependent NAD
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- IMP-specific 5'-nucleotidase 1
- Suppressor of disruption of TFIIS
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Nicotinate phosphoribosyltransferase
- NAD-dependent histone deacetylase SIR2
- NAD-capped RNA hydrolase NPY1
- NAD
Sequence:
MKKTFEQFRKSNLLFQVLKGPQHLECQKLFVLDSSFNPPHLAHFQLLSQTIKNFKLKDTRSHVLLLLAVNNADKLPKPASFPTRLEMMCLFADYLQEKLPQSVVSVGLTVFSKFIDKDKILHEQFVKGCSADIGYLVGFDTIARIFDEKYYHPLKISDVMESFMSGSQLYCLARGDCHLSAESQLRYASDILEGKFEPVIPREWGARIHVMQNDYPALRNVSSSEIRNKLKNGQVESLKDELPLCIYDYLINNKTIFD
Protein: Niemann Pick type C1 (Q7TMD4)
Organism: Mus musculus (Mouse)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MGAHHPALGLLLLLLCPAQVFSQSCVWYGECGIATGDKRYNCKYSGPPKPLPKDGYDLVQELCPGLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPKTQENKTNVKELEYFVGQSFANAMYNACRDVEAPSSNEKALGLLCGRDARACNATNWIEYMFNKDNGQAPFTIIPVFSDLSILGMEPMRNATKGCNESVDEVTGPCSCQDCSIVCGPKPQPPPPPMPWRIWGLDAMYVIMWVTYVAFLFVFFGALLAVWCHRRRYFVSEYTPIDSNIAFSVNSSDKGEASCCDPLGAAFDDCLRRMFTKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNTSVHIYEPYPAGADVPFGPPLNKEILHQVLDLQIAIESITASYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDSQVGDDFYIYADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTERLQRAWAWEKEFISFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLALGHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRGADDGQGSHASESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIDYFKSLAQYLHSGPPVYFVLEEGYNYSSRKGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWIDDYFDWVSPQSSCCRLYNVTHQFCNASVMDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVGDDTYIGATYFMTYHTILKTSADYTDAMKKARLIASNITETMRSKGSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKRHTTYERYRGTERKRLLNF
Protein: ATP synthase subunit a (F-ATPase protein 6) (P00852)
Organism: Emericella nidulans (Aspergillus nidulans)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MYQFNFILSPLDQFEIRDLFSLNANVLGNIHLSITNIGLYLSIGLLLTLGYHLLAANNKIIPNNWSISQEAIYATVHSIVINQLNPTKGQLYFPFIYALFIFILVNNLIGMVPYSFASTSHFILTFSMSFTIVLGATFLGLQRHGLKFFSLFVPSGCPLGLLPLLVLIEFISYLSRNVSLGLRLAANILSGHMLLSILSGFTYNIMTSGILFFFLGLIPLAFIIAFSGLELAIAFIQAQVFVVLTCSYIKDGLDLH
Protein: Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B) (O95972)
Organism: Homo sapiens (Human)
Function: May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Subcellular location: Secreted.
Interaction partners:
- Bone morphogenetic protein receptor type-1B
- Bone morphogenetic protein receptor type-2
- Growth/differentiation factor 9
- Factor in the germline alpha
- Homeobox protein NOBOX
- Follicle-stimulating hormone receptor
- Follistatin
- Forkhead box protein L2
- Protein POF1B
- Bone morphogenetic protein receptor type-1A
Sequence:
MVLLSILRILFLCELVLFMEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKPRLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTNVARPHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR
Protein: Inner membrane protein YohC (P0AD17)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Inner membrane protein YohD
- Uncharacterized protein YcgB
- UPF0339 protein YegP
- Regulator of sigma D
- Universal stress protein B
Sequence:
MSHVWGLFSHPDREMQVINRENETISHHYTHHVLLMAAIPVICAFIGTTQIGWNFGDGTILKLSWFTGLALAVLFYGVMLAGVAVMGRVIWWMARNYPQRPSLAHCMVFAGYVATPLFLSGLVALYPLVWLCALVGTVALFYTGYLLYLGIPSFLNINKEEGLSFSSSTLAIGVLVLEVLLALTVILWGYGYRLF
Protein: Protein INAPERTURATE POLLEN1 (Q9SUV9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the formation of pollen surface apertures, which arise by restriction of exine deposition at specific sites. The aperture length depends on the INP1 dosage. Does not play a role in specifying the number or position of apertures. Acts in a sporophytic manner.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23136373}. Note=Located at 3 equidistant spots close to the pollen equator. 3-D reconstruction demonstrates that INP1 is restricted not to just 3 spots, but to 3 long and narrow regions underlying the position of future apertures. {ECO:0000269|PubMed:23136373}.
Interaction partners:
- Serine/threonine-protein kinase D6PKL3
- Peroxisome biogenesis protein 3-2
- Protein GIGAS CELL1
- Peroxisome biogenesis protein 3-1
- La-related protein 6C
- Peroxisome biogenesis protein 16
- Dynamin-related protein 3A
- Inactive RHOMBOID-like protein 8
- Adenine phosphoribosyltransferase 3
- Peroxisome biogenesis protein 5
Sequence:
MPFSFFSRKKPSRRFNDFYEDWSKTLTENCLPLLRQSLSSAASASVLSSNVDLVLRHLVLYYETLDLAADHNTIPYLLFPSWRNSLETPFLFLGDIHPYLLTNLLRSFIDRENQDSDDEDEETSLDLVNQPLKMTMAWKDPSDELVKRIDQIECTMRLMVPGLMDRMRKTQRSFVARVSESWVSSYQVGKKKKLTATVATASTSVDEAAKIEMEELVSIFVDANRLRKSVIMDIVGATSEHQAALFLEGLCQFLAGFKDQILLQDFEILSLPN
Protein: Psi-producing oxygenase A (Fatty acid oxygenase ppoA) [Includes: Linoleate 8R-lipoxygenase (EC 1.13.11.60); 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase (EC 5.4.4.5)] (G5EB19)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Bifunctional heme-containing enzyme that oxidizes linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (within the N-terminal heme peroxidase domain), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (within the C-terminal P450 heme thiolate domain). Oxidized unsaturated fatty acids, so-called oxylipins, derived from endogenous fatty acids, influence the development of the asexual conidiophores and sexual cleistothecia and regulate the secondary metabolism. These substances were collectively named psi factors and are primarily a mixture of hydroxylated oleic, linoleic and alpha-linolenic acids. They are termed psi-beta, psi-alpha, and psi-gamma, respectively (By similarity).
Interaction partners:
- Uncharacterized protein
- Lysophospholipase
- Patatin-like phospholipase domain-containing protein
Sequence:
MGEDKETNILAGLGNTISQVENVVAASLRPLPTATGDGTYVAESTQTGLAKDLSHVDLKDVRTLAEVVKSAATGEPVDDKQYIMERVIQLAAGLPSTSRNAAELTKSFLNMLWNDLEHPPVSYLGADSMHRKADGSGNNRFWPQLGAAGSAYARSVRPKTMQSPSLPDPETIFDCLLRRKEYREHPNKISSVLFYLASIIIHDLFQTDPKDNSVSKTSSYLDLSPLYGNNQDEQNLVRTFKDGKLKPDCFATKRVLGFPPGVGVLLIMFNRFHNYVVDQLAAINECGRFTKPDESNVDEYAKYDNNLFQTGRLVTCGLYANIILKDYVRTILNINRTDSTWSLDPRMEMKDGLLGEAAAMATGNQVSAEFNVVYRWHACISKRDEKWTEDFHREIMPGVDPSTLSMQDFVAGLGRWQAGLPQEPLERPFSGLQRKPDGAFNDDDLVNLFEKSVEDCAGAFGASHVPAIFKSVEALGIMQARRWNLGTLNEFRQYFNLAPHKTFEDINSDPYIADQLKRLYDHPDLVEIYPGVVVEEAKDSMVPGSGLCTNFTISRAILSDAVALVRGDRFYTVDYTPKHLTNWAYNEIQPNNAVDQGQVFYKLVLRAFPNHFDGNSIYAHFPLVVPSENEKILKSLGVAEKYSWEKPSRISHPIFISSHAACMSILENQETFKVTWGRKIEFLMQRDKHQYGKDFMLSGDRPPNAASRKMMGSALYRDEWEAEVKNFYEQTTLKLLHKNSYKLAGVNQVDIVRDVANLAQVHFCSSVFSLPLKTDSNPRGIFAESELYKIMAAVFTAIFYDADIGKSFELNQAARTVTQQLGQLTMANVEIIAKTGLIANLVNRLHRRDVLSEYGIHMIQRLLDSGLPATEIVWTHILPTAGGMVANQAQLFSQCLDYYLSEEGSGHLPEINRLAKENTPEADELLTRYFMEGARLRSSVALPRVAAQPTVVEDNGEKLTIKAGQVVMCNLVSACMDPTAFPDPEKVKLDRDMNLYAHFGFGPHKCLGLDLCKTGLSTMLKVLGRLDNLRRAPGAQGQLKKLSGPGGIAKYMNEDQSGFTPFPSTMKIQWDGELPQLKEDF
Protein: Autoinducer 2 import system permease protein LsrC (AI-2 import system permease protein LsrC) (P77672)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable).
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Autoinducer 2 import system permease protein LsrD
- Autoinducer 2 import ATP-binding protein LsrA
- Autoinducer 2-binding protein LsrB
- 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
- (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase (Autoinducer 2-degrading protein LsrG) (AI-2-degrading protein LsrG) (Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase) (Phospho-AI-2 isomerase)
- Transcriptional regulator LsrR
- Autoinducer-2 kinase
- Ribose import binding protein RbsB
- Ribose import ATP-binding protein RbsA
- D-allose import ATP-binding protein AlsA
Sequence:
MLKFIQNNREITALLAVVLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLTRNIDVSVGSITGMCAVLLGMLLNAGYSLPVACVATLLLGLLAGFFNGVLVAWLKIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLLGVSAIGWLTIILVAFMAWLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGLEMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAVLVFDGRLRCALERNLRRQKYARFMTPPPSVKPASSGKKREAA
Protein: Protein sarah (Protein nebula) (Q9XZL8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for elongation of meiosis I spindle. Critical for ovulation, meiotic progression in oocytes and female courtship behavior, including their postmating changes. Regulates female meiosis by controlling calcineurin activity in the germline. Has a role in calcium signaling during egg activation; bcd mRNA polyadenylation and translation in the oocyte.
Interaction partners:
- Serine/threonine-protein phosphatase 2B catalytic subunit 2
- Calcineurin subunit B type 1
- Serine/threonine-protein phosphatase 2B catalytic subunit 3
- Serine/threonine-protein phosphatase 2B catalytic subunit 1
Sequence:
MSDAAKSNNNASADAPDPTTPDATGEADAANAATPTTPRGNHNNNNSANGRSKNKLKSTQNSSGGGSIDKLSPDQDIFINAADGLPNQHPSLPKEGDVDSDTEPEVDADSFDDLPTSIIVTNIHSEVFANPELKHAMEELFRTFSESATFQWLRSFRRLRVNYDNAIAAANARIKLHQYEFNKKTVITCYFAQPVTPVSNKNLQPPAPVKQFLISPPASPPAGWEPREEGEPLVNHDLLAALASLTPGESHELHPQSEDQPAIIVHTAMLAETGPGLQVKAPIVQTKCPERA
Protein: Epididymis-specific CRES-like protein (Q2PDL1)
Organism: Macaca mulatta (Rhesus macaque)
Interaction partners:
Sequence:
MMAEPWQALRLLLAILLTLMTLTYQARKKTFLSVQEVTAIENYAKDTLQWITDQYNKESDDKYHFRIFRVLKVEKRITDHLEYRLNVEMQRTTCQKPETTNCAPQEGELHKQVNCFFSVFAIPWFEQYKILNKTCSSD
Protein: Polyamine export protein (P0AE45)
Organism: Escherichia coli (strain K12)
Function: Involved in cadaverine and putrescine tolerance in stationary phase. May facilitate the efflux of both cadaverine and putrescine from the cytoplasm, reducing potentially toxic levels under certain stress conditions.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MLNSILVILCLIAVSAFFSMSEISLAASRKIKLKLLADEGNINAQRVLNMQENPGMFFTVVQIGLNAVAILGGIVGDAAFSPAFHSLFSRYMSAELSEQLSFILSFSLVTGMFILFADLTPKRIGMIAPEAVALRIINPMRFCLYVCTPLVWFFNGLANIIFRIFKLPMVRKDDITSDDIYAVVEAGALAGVLRKQEHELIENVFELESRTVPSSMTPRENVIWFDLHEDEQSLKNKVAEHPHSKFLVCNEDIDHIIGYVDSKDLLNRVLANQSLALNSGVQIRNTLIVPDTLTLSEALESFKTAGEDFAVIMNEYALVVGIITLNDVMTTLMGDLVGQGLEEQIVARDENSWLIDGGTPIDDVMRVLDIDEFPQSGNYETIGGFMMFMLRKIPKRTDSVKFAGYKFEVVDIDNYRIDQLLVTRIDSKATALSPKLPDAKDKEESVA
Protein: Probable transcriptional regulatory protein DVU_2259 (P62035)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00693}.
Interaction partners:
- Aspartate--tRNA
- Methionine--tRNA ligase
- Large ribosomal subunit protein bL19
- Crossover junction endodeoxyribonuclease RuvC
- Ribosomal RNA large subunit methyltransferase E
- Tyrosine--tRNA ligase
Sequence:
MAGHSKWANIQHRKGRQDAKRGKMFTKAAKEIIIAAKAGGDPVGNSRLRAAIAAAKAINLPKDKIENAIKKGTGELAGGDILEMAYEGYGPGGVALIVEVATDNKNRTVAEVRHILSKHGGSMGESGCVAWMFDRKGVITLEKDKYTEEQLMEVALEAGAEDVTDEGESWEVVTAAADFNAVREALEAAGVEMQSAEFTMVPQNEIEVDAETGRKLMRLVDALEDNDDVQNVHANFDLPDELLAELG
Protein: Probable protein phosphatase 2C 17 (AtPP2C17) (EC 3.1.3.16) (Q8L7I4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MPKICCSRSATQVVVAQKSNSGKGRNGEGGIKYGFSLIKGKSNHSMEDYHVAKFTNFNGNELGLFAIFDGHKGDHVAAYLQKHLFSNILKDGEFLVDPRRAIAKAYENTDQKILADNRTDLESGGSTAVTAILINGKALWIANVGDSRAIVSSRGKAKQMSVDHDPDDDTERSMIESKGGFVTNRPGDVPRVNGLLAVSRVFGDKNLKAYLNSEPEIKDVTIDSHTDFLILASDGISKVMSNQEAVDVAKKLKDPKEAARQVVAEALKRNSKDDISCIVVRFR
Protein: BEN domain-containing protein 6 (Q5SZJ8)
Organism: Homo sapiens (Human)
Function: Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6PFX2}.
Interaction partners:
- E3 SUMO-protein ligase ZNF451
Sequence:
MQKIVQTDEITNTQAFRKGKRKRTETMDSENANSDMDKGQRDPYSGNAFLPGESSSEDEEPLAELSKEELCAKIKSLKEKLTNTRKENSRLRQSLVMLQVLPQAVTQFEELVGMAEALLKGGGTMSTSASTLWRATNNSSPDSFASTCSNSNSNSSSPVSLKPEEEHQTDEKQFQIEKWQIARCNKSKPQKFINDLMQVLYTNEYMATHSLTGAKSSTSRDKAVKPAMNQNEVQEIIGVTKQLFPNTDDVSIRRMIGQKLNNCTKKPNLSKNLNSQDIK
Protein: Golgin-45 (Basic leucine zipper nuclear factor 1) (Q6AYB8)
Organism: Rattus norvegicus (Rat)
Function: Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:11739401}.
Interaction partners:
- Golgi reassembly-stacking protein 2
- Ras-related protein Rab-2A
- Golgi reassembly-stacking protein 1
- Golgi reassembly stacking protein 2
- Golgi resident protein GCP60
- Golgin subfamily A member 5
- General vesicular transport factor p115
Sequence:
MEKMTTLKSFESKGILTSTPIRGAGDGMETEEPPKSVEVTHGVQPINQHVLPSPRKKVPSDSPGVLQLGKILNEKTVEVEAVRIFVPKAAITHDIPTKSAKVKSLGHHREELHNQSEVVTDPRKELSEVKKVLEKLKNSERRLLQDKEGLSNQLRVQTEVNRELKKLLVASVGDDPQYHFERLAREKNQLILENEALGRNTAQLSEQLERMSIQCDVWRSKFLASRVMADELTNFRVVLQHQNRDAQSAIQDLLSEREQFRQEMISTQKFLEELLVSLQWGREQTYSPNTQPHSTADLALTNHRLAEAVHAHLLGNVGISHPKRTPATAEVCSTPAEKMAEKVLRILDPVACTESSPDNAFAESTLLTTKKNIGRFHPYTRYENITFNCCSHCQGELLAL
Protein: Integrator complex subunit 13 (F8VRX9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRSKKE
Protein: Transmembrane GTPase fzo (EC 3.6.5.-) (Protein fuzzy onions) (O18412)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis. In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Essential for fertility.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:9230308}; Multi-pass membrane protein {ECO:0000269|PubMed:9230308}.
Interaction partners:
- E3 ubiquitin-protein ligase parkin
- Serine/threonine-protein kinase Pink1, mitochondrial
- Transmembrane GTPase Marf
- Dynamin
- Mitochondrial fission 1 protein
- Cell death protein rpr
- Mitochondrial Rho GTPase
- Voltage-dependent anion-selective channel
- Dynamin-like GTPase OPA1, mitochondrial
- dynamin GTPase
Sequence:
MAESDSGESTSSVSSFISSSSSSRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETVLLKDRQMLEHLCAFSSRVEAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQEDEHMELSALSQLASAHSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLLVDELGVYSTAQEAWERIYHVSALEALHIRNGQITNPSGQTQQRYQEFLRFENDFSNCLAVSALKTKFGPHLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEELTEMTQRVGRCVLNDQIKTLIPSSVLSFSQPFHPEFPAQIGQYQRSLCAHLDKLLEDRVLQCLSIPLQRKILDIEKEIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNLPLHASPFRIQKLQNGHKKCSPLPPLVNGNHWQMLESLVKSKGSLGTVLLSAMAIRSFNWPIVLILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLATVRNCWEAQSNETLNDLNVRTAELTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYLTKS
Protein: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2-2) (OGDC-E2-2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2) (E2K-2) (Q8H107)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14671022, ECO:0000305|PubMed:25732537}.
Interaction partners:
- 2-oxoglutarate dehydrogenase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Dihydrolipoyl dehydrogenase 2, mitochondrial
- Dihydrolipoyl dehydrogenase 2, chloroplastic
- Succinate--CoA ligase subunit alpha-1, mitochondrial
- Dihydrolipoyl dehydrogenase 1, mitochondrial
- Dihydrolipoyl dehydrogenase 1, chloroplastic
- Succinate--CoA ligase subunit alpha-2, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- Putative 2-dehydropantoate 2-reductase
Sequence:
MMMRAVIRRAASNGSSPSLFAKSLQSSRVAASSPSLLSGSETGAYLHRGNHAHSFHNLALPAGNSGISRSASLVSSTLQRWVRPFSAETGDTVEAVVPHMGESITDGTLATFLKKPGERVQADEAIAQIETDKVTIDIASPASGVIQEFLVNEGDTVEPGTKVAIISKSEDTASQVTPSQKIPETTDTKPSPPAEDKQKPRVESAPVAEKPKAPSSPPPPKQSAKEPQLPPKERERRVPMTRLRKRVATRLKDSQNTFALLTTFNEVDMTNLMKLRSQYKDAFYEKHGVKLGLMSGFIKAAVSALQHQPVVNAVIDGDDIIYRDYVDISIAVGTSKGLVVPVIRGADKMNFAEIEKTINSLAKKANEGTISIDEMAGGSFTVSNGGVYGSLISTPIINPPQSAILGMHSIVSRPMVVGGSVVPRPMMYVALTYDHRLIDGREAVYFLRRVKDVVEDPQRLLLDI