wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphoenolpyruvate carboxylase 2 (PEPC 2) (PEPCase 2) (ppcC) (EC 4.1.1.31) (Q9FV65)
Organism: Flaveria trinervia (Clustered yellowtops) (Oedera trinervia)
Function: Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P27154}.
Interaction partners:
Sequence:
MANRNLEKLASIDAQLRLLVPGKVSEDDKLIEYDALLLDKFLDILQDLHGEGLKETVQECYELSAEYEGKHDPKKLEELGNVLTSLDPGDSIVIAKAFSHMLNLANLAEEVQIAYRRRIKLKKGDFADEASATTESDIEETFKKLVHKLKKSPEEVFDALKNQTVDLVFTAHPTQSVRRSLLQKHGRIRDCLAQLYAKDITPDDKQELDEALHREIQAAFRTDEIRRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGINERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAANMYFSQIEDLMFEMSMWRCSDELRVRAEELHRSSSKRDVKHYIEFWKQVPPTEPYRVILGDVRDKLYNTRERARHLLAHDVSDIPEESVYTNVEQFLEPLELCYRSLCACGDRVIADGSLLDFLRQVSTFGLSLVRLDIRQESDRHTDVLDAITQHLEIGSYREWSEEKRQEWLLSELSGKRPLFGPDLPKTEEIADVLDTFHVLAELPADCFGAYIISMATSPSDVLAVELLQRECHVKQPLRVVPLFEKLADLEAAPAAVARLFSIEWYKNRIDGKQEVMIGYSDSGKDAGRLSAAWQLYKAQEELINVAKKFGVKLTMFHGRGGTVGRGGGPTHLAILSQPPETIHGSLRVTVQGEVIEQSFGEEHLCFRTLQRFCAATLEHGMNPPISPRPEWRALMDEMAVYATEQYREIVFKEPRFVEYFRLATPELEYGRMNIGSRPSKRKPSGGIESLRAIPWIFAWTQTRFHLPVWLGFGAAFKYAIEKDIKNLHMLQEMYKTWPFFRVTIDLVEMVFAKGDPGIAALNDKLLVSEDLWSFGESLRANYEETKNLLLKIAGHKDLLEGDPYLRQRLRLRDSYITTLNVCQAYTLKRIRDPNYHVTFRPHISKEYSEPSSKPADEYIKLNPKSEYAPGLEDTLILTMKGIAAGMQNTG
Protein: CG12780 protein (A0ZWY4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGYQVPLARVTSSERRGFEVSIDDEPGISLFGFHGRLNEPIVDLGNQTWAADIIGKDKDGRWTYTNRDVELKDGDVLYYWTTVRYNGRDYHRMNQSAGF
Protein: Interleukin-1 (F4ZWC1)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Lysosome {ECO:0000256|ARBA:ARBA00004371}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
Interaction partners:
Sequence:
MAFVPDLDVLESSSLSEETFYGPSCLCLQKKPRLDSEHTTVDVQVTVRKGRGARSFRRAAVLVVAMTKLLRRPRSRDFADSDLSALLEEVFEPVTFQRLESSYAGAPAFRYTRSQSFDIFDINQKCFVLESPTQLVALHLQGPPSSQKVRLNIALCRPRGPRGSAGTGQMPVALGIKGYKLYMSCVMSGTEPTLQLEEADVMRDIDSVELTRFIFYRLDSPTEGTTRFESAAFPGWFICTSLQPRQPVGITNQPDQVNIATYKLSGR
Protein: ATP-dependent RNA helicase DBP8 (EC 3.6.4.13) (DEAD box protein 8) (P38719)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11222764, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Probable ATP-dependent RNA helicase DHR2
- Something about silencing protein 10
- U3 small nucleolar RNA-associated protein 22
- Pre-rRNA-processing protein ESF2
- Essential nuclear protein 1
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- Probable ATP-dependent RNA helicase DHR1
- Ribosome biogenesis protein ENP2
- Protein BFR2
- Ribosome biogenesis protein BMS1
Sequence:
MADFKSLGLSKWLTESLRAMKITQPTAIQKACIPKILEGRDCIGGAKTGSGKTIAFAGPMLTKWSEDPSGMFGVVLTPTRELAMQIAEQFTALGSSMNIRVSVIVGGESIVQQALDLQRKPHFIIATPGRLAHHIMSSGDDTVGGLMRAKYLVLDEADILLTSTFADHLATCISALPPKDKRQTLLFTATITDQVKSLQNAPVQKGKPPLFAYQVESVDNVAIPSTLKIEYILVPEHVKEAYLYQLLTCEEYENKTAIIFVNRTMTAEILRRTLKQLEVRVASLHSQMPQQERTNSLHRFRANAARILIATDVASRGLDIPTVELVVNYDIPSDPDVFIHRSGRTARAGRIGDAISFVTQRDVSRIQAIEDRINKKMTETNKVHDTAVIRKALTKVTKAKRESLMAMQKENFGERKRQQKKKQNDGKSLRS
Protein: Ventral anterior homeobox 1 (Q5SQQ9)
Organism: Homo sapiens (Human)
Function: Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Zinc finger protein 462
- Putative Polycomb group protein ASXL2
- Interferon regulatory factor 6
Sequence:
MFGKPDKMDVRCHSDAEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDCNKSKSNSAADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQGKDSELRSVVSETAATCSVLRLLEQGRLLSPPGLPALLPPCATGALGSALRGPSLPALGAGAAAGSAAAAAAAAPGPAGAASPHPPAVGGAPGPGPAGPGGLHAGAPAAGHSLFSLPVPSLLGSVASRLSSAPLTMAGSLAGNLQELSARYLSSSAFEPYSRTNNKEGAEKKALD
Protein: Secreted frizzled-related protein 3 (sFRP-3) (Frezzled) (Fritz) (Frizzled-related protein 1) (FrzB-1) (Q92765)
Organism: Homo sapiens (Human)
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Matrilin-3
- Asporin
- Wnt inhibitory factor 1
- Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
- Dickkopf-related protein 1
- Dickkopf-related protein 2
- Dickkopf-related protein 4
- Catenin beta-1
- Low-density lipoprotein receptor-related protein 5
- Proto-oncogene Wnt-1
Sequence:
MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARN
Protein: Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) (P62881)
Organism: Mus musculus (Mouse)
Function: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).
Subcellular location: Membrane {ECO:0000269|PubMed:8071339, ECO:0000269|PubMed:8910430}.
Interaction partners:
- Regulator of G-protein signaling 7
- Regulator of G-protein signaling 9
- Regulator of G-protein signaling 6
- Regulator of G-protein signaling 9-binding protein
- Regulator of G-protein signaling 11
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Regulator of G-protein signaling 7-binding protein
Sequence:
MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLNYCSTCAEIMATDGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
Protein: Putative fatty-acid--CoA ligase fadD25 (EC 6.2.1.-) (Acyl-CoA synthetase) (P9WQ45)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Peptide synthetase MbtE
- Uncharacterized protein Rv1509
- Peptide synthetase MbtF
- Uncharacterized protein Rv1510
- Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15
- Isonitrile lipopeptide synthase
- GDP-mannose 4,6-dehydratase
- Probable antitoxin MazE4
- Phenyloxazoline synthase MbtB
- Phenolphthiocerol/phthiocerol polyketide synthase subunit B
Sequence:
MSVVESSLPGVLRERASFQPNDKALTFIDYERSWDGVEETLTWSQLYRRTLNLAAQLREHGSTGDRALILAPQSLDYVVSFIASLQAGIVAVPLSIPQGGAHDERTVSVFADTAPAIVLTASSVVDNVVEYVQPQPGQNAPAVIEVDRLDLDARPSSGSRSAAHGHPDILYLQYTSGSTRTPAGVMVSNKNLFANFEQIMTSYYGVYGKVAPPGSTVVSWLPFYHDMGFVLGLILPILAGIPAVLTSPIGFLQRPARWIQMLASNTLAFTAAPNFAFDLASRKTKDEDMEGLDLGGVHGILNGSERVQPVTLKRFIDRFAPFNLDPKAIRPSYGMAEATVYVATRKAGQPPKIVQFDPQKLPDGQAERTESDGGTPLVSYGIVDTQLVRIVDPDTGIERPAGTIGEIWVHGDNVAIGYWQKPEATERTFSATIVNPSEGTPAGPWLRTGDSGFLSEGELFIMGRIKDLLIVYGRNHSPDDIEATIQTISPGRCAAIAVSEHGAEKLVAIIELKKKDESDDEAAERLGFVKREVTSAISKSHGLSVADLVLVSPGSIPITTSGKIRRAQCVELYRQDEFTRLDA
Protein: Dimethyl sulfoxide reductase transcriptional activator (DMSO reductase transcriptional activator) (DMSO-responsive regulator DmsR) (DNA-binding protein DmsR) (D4GQ08)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: Involved in activating dmsEABCD gene expression related to dimethyl sulfoxide (DMSO) reductase. Required for anaerobic respiration on dimethyl sulfoxide (DMSO).
Interaction partners:
Sequence:
MADSTSGVAEAKADTLREQHLQLLLEIEPAKRCSCPLAGPDSAVEDVHTQLDGDVCHAEVTVGDGDASKVVHATTSVGDDCLCRAFAEFECVPRIRRADGECIVVETYLSDRAVITDLVERLDELTERVCLRRLTSDGRGDSTESKTATIDLSSLTAKQREAALIAVHHGYYETPRRTELATLAEALGISKSALSQRLNAVEAKLATAVFDSE
Protein: RQC trigger complex helicase rqt2 (EC 3.6.4.13) (Meiotically up-regulated gene 81 protein) (O60072)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (By similarity). Drives the splitting of stalled ribosomes that are polyubiquitinated, as part of the ribosome quality control trigger (RQT) complex (By similarity). Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- RQC trigger complex subunit RQT4 homolog
- Pre-mRNA-splicing factor spp42
- Pre-mRNA-splicing factor prp1
- U2 snRNP component prp10
- Pre-mRNA-processing factor 31
- Pre-mRNA-processing protein 45
- U4/U6.U5 tri-snRNP-associated protein snu66
- U4/U5/U6 small nuclear ribonucleoprotein prp3
- Uncharacterized protein C15D4.13c
- Uncharacterized WD repeat-containing protein C227.12
Sequence:
MEVELNYVVNHLEKLGPASFCDTPYSFSLSDSNAELGALSLKVDEILKTNYNLINPEDVTDSDNNEFALKDLTWLQNCCNEISQSSSTELDASVLFEAVIMSLKATEDQCAIQEDLLNLVGLDHIDLISDIVANSSNLIEEYMNQNDTSIAAQLSDGYTSEAGSSATHGQGLLDSLKSRPRRFSRSRDNRGPLFTGQQVFEVEKYPHVYGDKRLGNTISVIGKKFALPAGSEREDYQKYEEIIVPHAQRAPQMQGEKLLEISSMDILCRKTFLSYQTLNRIQSLVYPIAYKTNENMLICAPTGAGKTDVALLAMLQTISNYVESMNLMDESEPLDVHRDDFKIVYIAPMKALAAEVVEKMGKRLAWLGLKTRELTGDMQLTKTEIAETQILVTTPEKWDVVTRKSVGDTQLAEKVRLVIIDEVHMLHDERGAVIESLVARTQRLVETSQQMIRIVGLSATLPNYLDVADFLGVNRYKGLFYFSSAFRPCPIEQHFIGAKGSPKIVNSNIDEACFDKVLKLIQEGHQVMIFVHSRKETINSAKKLREQFFHEGEADLLDNSQHEKYSLAQRDVSKSKNKELKELFKYSMGIHNAGMLRSDRHLTERLFSMGILKILCCTATLAWGVNLPAYAVLIKGTQLYDPQKGSFVDLGVLDVLQIFGRAGRPQFESSAVAYIITTHDKLSHYISVVTQQSPIESRFTDRLVDNLNAEVSLGTVTNIDEAVSWLGYTYLYIRMRRNPLVYGIAYDELVEDPLLGSKRRELVSVAAGRLADNQMIVYNKKNGYLIPKDLGRIASNYYINYQTVSTLNNLLKSKMSEADIIALLSQCSEFSQIKSRENEHRELESLMENSSPCQLRDSISNTSGKVNVILQSYISRAHVEDFTLTSDTNYVAQNAGRITRALFEIAMSRTWASAFTILSLNKSIDRRQWSFEHPLLQFDLPHDLAVKVENQCGSLSLEELSDMSTGELGDLIHNRKMGPTVKKFISKLPLLNINVDLLPLTKNVLRLVLNITPNFNWDMRYHGNSQMFWIFVEDSNGLEILHHEQLLLNKRNVSTSHLLSFTIPVSNPLPSQLYIIAVSDKWLGAETVTPVSLSNVVFHDDSNPITELLDLQPLPITALHDPVLEGICAKRFSFFNAVQTQFFHTIYHTDTNIFVGAPTGSGKTMAAELATWRALHNYPKSKVVYIAPMKALVKERVKDWGHRLVEPMGISMIELTGDTNPDVKAVTNANIIITTPEKWDGITRSWKSRKYVQDVSLIILDEIHLLGSDRGPVLEMIVSRMNYVASQTNKKVRVLGLSTAVANANDLANWLNIRDGLFNFRHSVRPVPLEIYIDGFPGRAYCPRMMSMNKPAFQAIKTHSPTQPVLIFVSSRRQTRLTAKDLIAFCGLEDNPRRFLYMDEEELEMIVSEVEDKSLKLALPFGIALHHAGLTENDRKISEELFVNNKVQILIATSTLAWGVNTPAHLVIVKGTEYYDAKIGGYKDMDLTDVLQMLGRAGRPQFDNSGVARIFVQDIKKSFYKHFLHSGFPVESYLHKVLDNHLNAEIATGTIDCIQGAMDFLTCTYFYRRVHQNPVYYGADGDDQKSIDTYLSKLVVTAFNELEKSACIYRVNEETYAPTTLGRIVSYYYLFHTTIRNFVQKITENAEFDLALQLLAEASEFDDLAIRHNEDLINIEINKSLKYSAACLNLPMVDAHVKAFILTQAHMARLKLPVDDYVTDTSTVLDQVIRIIQSYIDVSAELGYSHVCLQYISLMQCLKQACYPSEIYRASLPGLNASSEKEARDYLNKFAGNKTDELYQMLCNDPNVFDIESLVNSLISYPKMNIEVSQSSSDKLLLYLRRLNQPLNPDFYIFAPLFPKPQSEGFFVLIIDSETQELFAIRRASFAGRRNDDSIRLSLRISMDIPPTCRNRNVKVMVVCDGYPLIYEHKIVLMI
Protein: Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Q4Q253)
Organism: Leishmania major
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03011}.
Interaction partners:
- Uncharacterized protein
- Putative eukaryotic translation initiation factor 3 subunit 8
- CSN8/PSMD8/EIF3K domain-containing protein
- Eukaryotic translation initiation factor 3 subunit 7-like protein
- Eukaryotic translation initiation factor 3 subunit E
- Putative translation initiation factor
- Eukaryotic translation initiation factor 3 subunit I
- RRM domain-containing protein
- Putative elongation initiation factor 2 alpha subunit
- 40S ribosomal protein S3
Sequence:
MGLYQHHRCPPPQLLPPQKHGCAVIHSYPPYTPSFPVYQVCLCVHLLLVIVSDCAIFIFLLASESSLSRPLSSPKTRTTQRTLTHVFAKMATNPDIETDIPRDVYQFFRGLNRAVERRDAAAMHDLYESQFDALTKNYYMAGHGQFRSWPALRLEQVSSCFRGNHMAELVYSFLFYKHLFMDNRSVRAPDAEGAWKTYSELLPMLKSYELPNWMLWDIFDEFLYQMTVVYQKVFVTEGIWAVPEVSRLLNEVIDNSRLLELVKQPDFLEDIHRGPNTGALSGFYAIVTKSKLNVLLGDYYSALTDLEPLDVYNKGRAVLTRVSPCAVSVFYHIGFSYLMIHRFEDASNAFRRCVTVKLNGRRFSERVQQDAAYMYVCARVLGGMPINNLTSYLDSRKVAAFEDDRESLRTGDEERFRDVFDRCSPKFLTVPPSDGSPVKGSEGRELQARMFRRAVQQQQDIIKLRGYFKVYQNTKMNLLETLLEVDDGYAPLFALKMRSRQLVHDGVTADLLQGVFTSSSEFDCIVQDDNVEVVPSMTFGGIEQKLLNKIKNTQRDIEVAKRKFNQTRNRDEGGNKRKDQRDQKRRPNQQQLHGGVGNNAGSANRSSNNVNRHPRQKMAAQPMTSNLFNRNDN
Protein: Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) (Q5R3F8)
Organism: Homo sapiens (Human)
Function: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLRLGLCAAALLCVCRPGAVRADCWLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLLVPRPYHSLNAITVLQAKCRNGSLPARPVSHPTPYSTDAQREPDENSGFNPDEILSVEPPASSTTDASAGPAIKLHHVTFTSATLVVIIPHPYSKMYILVQYNNSYFSDVMTLKNKKEIVTLDKLRAHTEYTFCVTSLRNSRRFNHTCLTFTTRDPVPGDLAPSTSTTTHYIMTILGCLFGMVIVLGAVYYCLRKRRMQEEKQKSVNVKKTILEMRYGADVDAGSIVHAAQKLGEPPVLPVSRMASIPSMIGEKLPTAKGLEAGLDTPKVATKGNYIEVRTGAGGDGLARPEDDLPDLENGQGSAAEISTIAKEVDKVNQIINNCIDALKLDSASFLGGGSSSGDPELAFECQSLPAAAAASSATGPGALERPSFLSPPYKESSHHPLQRQLSADAAVTRKTCSVSSSGSIKSAKVFSLDVPDHPAATGLAKGDSKYIEKGSPLNSPLDRLPLVPAGSGGGSGGGGGIHHLEVKPAYHCSEHRHSFPALYYEEGADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGYSSSPEYSSESTHKIWERFRPYKKHHREEVYMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQQKL
Protein: DNA-directed RNA polymerase II subunit RPB11 (RNA polymerase II subunit B11) (B13.6) (DNA-directed RNA polymerase II 13.6 kDa polypeptide) (P38902)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft. Seems to be involved transcript termination.
Subcellular location: Nucleus.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
Sequence:
MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDHTLGNLIRAELLNDRKVLFAAYKVEHPFFARFKLRIQTTEGYDPKDALKNACNSIINKLGALKTNFETEWNLQTLAADDAF
Protein: ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) (O88335)
Organism: Mus musculus (Mouse)
Function: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P48048}; Multi-pass membrane protein {ECO:0000255}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000250|UniProtKB:P48048}.
Interaction partners:
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Serine/threonine-protein kinase Sgk1
- Serine/threonine-protein kinase WNK4
- Solute carrier family 12 member 3
- Barttin
- Chloride channel protein ClC-Kb
- Epithelial sodium channel subunit alpha
- Serine/threonine-protein kinase WNK1
- Cystic fibrosis transmembrane conductance regulator
- Extracellular calcium-sensing receptor
Sequence:
MFKHLRRWFVTHIFGRSRQRARLVSKDGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYIPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM
Protein: Thioredoxin-like fold domain-containing protein (Q582F0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLERRALMNANVHIQADLCCRRSDLGRCVIQCFVTPKRLCSTRSRSNTTSGTRDIRITAGDDTANASATLGIQRGDKDAATRESYDARVQYSHHQGADKRVMSRKESSTAFGVNGTAKATSRVSYSLDRNHMGNKFLRKLTDLETAGLSRPSATSQVARRHNRAAEQKVLGERKKMLVFRDVGMDLDKPILSRDVFLVLKYFRYGIEYAVDNELERMLRYFNEHALNELKIIQNSKLMRGPAALSQKKVRTVCESLGFDTVPFFPTLKAARVSQYCSLNEEAEKRLCILMKQKTFFNNTAELTEESLGKLYLNRSFDETDTQQLTEISRVMFRRPAVVIYSQLGQKLGAQADLEWRRLAYSVLNPKLLSYLPKENAKGEGHVNSEEAQHGRGLRRCRNETLACPVDRNMPISVLSLRSMDVYKYRWVHKLYVRRFAGSLFPTATGAESSDDRSLLNGFITSSSTFVGSKLLVPFYKSVGLRNYLSPHVILVDHEGVIRWVSGGCPDDYEKESFPTLLRQLEDEYRLAAR
Protein: Meiotically up-regulated gene 70 protein (O13965)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm. Nucleus membrane; Multi-pass membrane protein.
Interaction partners:
- Small ribosomal subunit protein uS2m
- 5'-AMP-activated protein kinase subunit beta
- Multifunctional tryptophan biosynthesis protein
Sequence:
MTVGTLSVVSSTASDTASHVSDTRKRQYQRDEALRKKIISELGKKSGNFESPVRKIRRNGEPGTVDSAALDPALTVHMQSLVTETAQLMAAKRQNCVLVVDDDEQLAGIVTATDIATRCVGAGLNARQTLIADIMSTSPLCITSDTRFDDALLLMIEHKFRHLPVVSDGGPDGSAGDEGDVIGIINMRACLREPLNRIARQQEAAQKLVEALEGAQEEIENKSVSGNTNSSSVSGNHAAEFLEYVESLKKKASGLEIMSLIDSSEEPFLVGTRTTVAEATESMARSGVSAVLVMDNGAVSGVFTAHDVVLRVLAAGLDPYRSSVIRVMTPHPDCALASLRVSTALERMIEGKFSNLPVVDESDAIIGMLSLFHLATAIEQTPEEEEEVFDQAENDAGIEPSNGFEDQQQQLLGNSNEVVENYDVNPPLPLNPLPSNTQQSESTYEYSARQLPKPPVQAWQNENLSSNNKPQEYVGVENDYNFSNNPPTAMSEQSFHPSVSQKPMDTPENGSNSFAASPYLQPYNSASQLAPSYVGSLPQYHGNPSFVEQALQDLVQPTDSASQIFPLNPQSPSQFTIKYRSIAGRVHRLRLDGINSVSDLRTAVEEREKEQLVTLTYIDDEGDVVELVSDSDLREAILLARRRGLPRLEVRGVAAFTNHLESSHPPISTVDSSIGSASVVEKGVANSIVDIHQPTAKADKGNSKKPIYIGIVSSSIVILAVSMWYLRRKR
Protein: Wilms tumor protein 1-interacting protein (WT1-interacting protein) (A6NIX2)
Organism: Homo sapiens (Human)
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).
Subcellular location: Cell junction, adherens junction. Nucleus {ECO:0000250}. Cytoplasm, P-body. Note=Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell-cell contacts into the cytosol and nucleus. The shift from cell contacts to intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3 hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By similarity). {ECO:0000250}.
Interaction partners:
- Protein salvador homolog 1
- Serine/threonine-protein kinase LATS1
- Serine/threonine-protein kinase LATS2
- LIM domain-containing protein ajuba
- LIM domain-containing protein 1
- Rab effector Noc2
- Rabphilin-3A
Sequence:
MQRSRAGADEAALLLAGLALRELEPGCGSPGRGRRGPRPGPGDEAAPALGRRGKGSGGPEAGADGLSRGERGPRRAAVPELSAQPAGSPRASLAGSDGGGGGGSARSSGISLGYDQRHGSPRSGRSDPRPGPGPPSVGSARSSVSSLGSRGSAGAYADFLPPGACPAPARSPEPAGPAPFPLPALPLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVACYHCEDCGLQLSGEEGRRCYPLAGHLLCRRCHLRRLQPGPLPSPTVHVTEL
Protein: UPF3 regulator of nonsense transcripts homolog B (yeast) (F6Q8N5)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XEYHAIVEFAPFQKAAKKKIKKRDTKVGTIEDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKRTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIERIPEREKIRDEPKIKVHRFLLQAVNQKNLLRKPEKGDEKELDKRDKTKRLDKENLNEERASGHSYTLPRRSDVELKDEKPKRLDDEGVRDYRDRDRDYERDQERMIRERERLKRQEEERRRQQQKERYEK