wanglab/gogpt-training-data huggingface dataset:
Protein: Leukosialin (B-cell differentiation antigen LP-3) (Leukocyte sialoglycoprotein) (Lymphocyte antigen 48) (Ly-48) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] (P15702)
Organism: Mus musculus (Mouse)
Function: Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (By similarity). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P13838}. Cell projection, uropodium {ECO:0000269|PubMed:21289089}. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). {ECO:0000250|UniProtKB:P13838, ECO:0000269|PubMed:21289089}.; SUBCELLULAR LOCATION: [CD43 cytoplasmic tail]: Nucleus {ECO:0000269|PubMed:19696198}. Nucleus, PML body {ECO:0000269|PubMed:19696198}. Note=The sumoylated form localizes to the PML body. {ECO:0000269|PubMed:19696198}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase C
- E-selectin
- Sialoadhesin
- Radixin
- Ezrin
- Intercellular adhesion molecule 1
- Moesin
- B-lymphocyte antigen CD19
- T-cell surface glycoprotein CD5
- Galectin-3
Sequence:
MALHLLLLFGACWVQVASPDSLQRTTMLPSTPHITAPSTSEAQNASPSVSVGSGTVDSKETISPWGQTTIPVSLTPLETTELSSLETSAGASMSTPVPEPTASQEVSSKTSALLPEPSNVASDPPVTAANPVTDGPAANPVTDGTAASTSISKGTSAPPTTVTTSSNETSGPSVATTVSSKTSGPPVTTATGSLGPSSEMHGLPATTATSSVESSSVARGTSVSSRKTSTTSTQDPITTRSPSQESSGMLLVPMLIALVVVLALVALLLLWRQRQKRRTGALTLSGGGKRNGVVDAWAGPARVPDEEATTTSGAGGNKGSEVLETEGSGQRPTLTTFFSRRKSRQGSLVLEELKPGSGPNLKGEEEPLVGSEDEAVETPTSDGPQAKDEAAPQSL
Protein: Serine proteinase-like BMK-CBP (P0C8M2)
Organism: Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Function: Binds in a dose-dependent manner to the breast cancer cell line MCF-7.
Subcellular location: Secreted {ECO:0000269|PubMed:18625260}.
Interaction partners:
Sequence:
IFGGTFAKNGEYPWMVVIDLPEFACGGVLISKKFVLTAAH
Protein: Interferon regulatory factor 3 (IRF-3) (Q14653)
Organism: Homo sapiens (Human)
Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis. Key transcription factor regulating the IFN response during SARS-CoV-2 infection.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:35922005, ECO:0000269|PubMed:36603579, ECO:0000305|PubMed:25636800}. Nucleus {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:35922005, ECO:0000269|PubMed:36603579, ECO:0000305|PubMed:25636800}. Mitochondrion {ECO:0000269|PubMed:25609812}. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757, PubMed:35922005). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:35922005}.
Interaction partners:
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon
- Serine/threonine-protein kinase TBK1
- Interferon regulatory factor 7
- CREB-binding protein
- Histone acetyltransferase p300
- Mitochondrial antiviral-signaling protein
- Transcription factor Jun
- Stimulator of interferon genes protein
- TIR domain-containing adapter molecule 1
- Ubiquitin-like protein ISG15
Sequence:
MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES
Protein: Splicing factor U2AF 59 kDa subunit (U2 auxiliary factor 59 kDa subunit) (U2AF59) (U2 snRNP auxiliary factor large subunit) (P36629)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Necessary for the splicing of pre-mRNA. The SF1-U2AF59-U2AF23 complex has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Splicing factor U2AF 23 kDa subunit
- Branchpoint-bridging protein
- U2 snRNP component prp10
- Pre-mRNA-splicing factor cdc5
- Spliceosome-associated protein 49
- Pre-mRNA-splicing factor prp12
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor sap145
- U1 snRNP-associated protein usp107
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MDLSSRLSSGSSRIPKRHRDYRDEEPRRERGSGGIGREDPRGHYGSERPRRRRRDESDFRRHRESRERSYREDERPRRERRYDDYEPRSLRYSSVGRSRSPPPSRERSVRSIEQELEQLRDVTPINQWKRKRSLWDIKPPGYELVTADQAKMSGVFPLPGAPRAAVTDPEKLLEFARSAEGSIIAPPPPLQPGASRQARRLVVTGIPNEFVEDAFVSFIEDLFISTTYHKPETKHFSSVNVCKEENFAILEVATPEDATFLWGLQSESYSNDVFLKFQRIQNYIVPQITPEVSQKRSDDYAKNDVLDSKDKIYISNLPLNLGEDQVVELLKPFGDLLSFQLIKNIADGSSKGFCFCEFKNPSDAEVAISGLDGKDTYGNKLHAQFACVGLNQAMIDKSNGMAILTELAKASSQSIPTRVLQLHNLITGDEIMDVQEYEDIYESVKTQFSNYGPLIDIKIPRSIGTRNSGLGTGKVFVRYSDIRSAEVAMEEMKGCKFNDRTIVIAFYGEDCYKANAW
Protein: Interferon gamma (B3F594)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
KGGPLFSEILKNWKEESDKKIIQSQIVSFYFKLFENLKDNQVIQRSMDIIKQDMFQKFLNGSSEKLEDFKRLIQIP
Protein: AKT1 substrate 1 (A0A8I5ZRQ9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSIWLCVLGVADGARMASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIAQAHRAATATRPPGPPPAPQPPSPAPSSPPRPALAREEDEEDEDEPTETETSGERLGGSDNGGLFMMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPAYPKLPATALPTQQYAKSLPVSVPVWAFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDNQVFGDLPRPRLNTSDFQKLKRKY
Protein: Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Paip1 protein) (Poly(A)-binding protein-interacting protein 1) (XlPaip1) (Q7ZYB4)
Organism: Xenopus laevis (African clawed frog)
Function: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9H074, ECO:0000305}.
Interaction partners:
Sequence:
MSDGFERAPGVGRGRGRGRGIETAEGGKTPGFSGASGAGDEPGRAKAAGSQQQEPLRPPRTGPPGGGGDAGAAQTSHKRTSPAAQLPAHTYTMAVSKAQPADRGRLLSNLSANAAEFYPSGYSVEANNCVEENGCYPVLPEGTLTEYVQDFLNHLTEQPGSFEAEVFPFSDVLNNCVTTDESLQELVELIYQQAISVPNFSYTGARLCNYLSNNLHINPQNQNFRQLLLKRCQTEFEKRDQAAKGDGAARKQFHAFVLFLGELYLNLEIKGAKGQVTRAEILQSGLQELLNSLFSNPVDDNLMCAVKLLKLTGSVLEDAWKEKALSCMEEVMLRMKNVVLDANCSRDVKQMLLKLVELRSSNWGRVHAASTFKEATPENDPNYFMNEPTFYTSEGVPFTAADPDYQEKYQELLDREDFFRDYDENGTDGGDSYFEDDDDNEMDPEMEEAYEKFCLESEHKKKQ
Protein: Meiotic coiled-coil protein 2 (O74438)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Rsm22-cox11 tandem protein 1
- Meiotically up-regulated gene 60 protein
- Meiotic coiled-coil protein 1
- Microtubule-associated protein ssm4
- Probable prefoldin subunit 6
- Meiotic expression up-regulated protein 18
- Meiotic expression up-regulated protein 23
Sequence:
MQSIDLRLPSTSANHSISESLEHSKSELNELSNVSESESYFDITKKLHALSTVVQRQQREIDNQKRDLCTKTKHIEELQTLLSNANIMSDGASSQNDAFAHNPSTSVSVELVRPVVGTKKHAVYATSAPKSMSLQDSLSVPSATALADVSSSLNYSRKLSSNSIKSTNAPVFGTAVKNVTGENILSASSSEENLNSNRNGDPKFRFSVSPWISSSNFNPYEASLANFQSDNCKLKSHNSLPSIRTNVRYSNSKPSTPLSPEDVDLGTYTVKNRDSWSNEVNLSASTNNLSTNTSGTLKPYSLSSSRSSSYSKGVNSAASLQSIWETMNNSNPSVIPESTSSREPAARYRKISERNAVYDWNVIIDKIIVSNDQQSSIFLQQKLKISSYDMKQNIVDSIISQIHPLMLNRFGNFLVQRCFEHGTAPQIRQMGSAMLGNMLKLATDPFGCHVVQKAIDNVTEDIKLAMMDELFLTIDVTIMHHYACHVWQKLFETQWYEYPVNVMNRVNNALRGKWHEVAVGENGSLVVQNMFENCVEKDKRECIEEIIFHLDGIARGQWGNWVVQHMVENGQGEDLKRVIDALLNRAVEFSIDQFASKVIEKAIKSGPKNFISLYLKQITNARVDRTRQPLIDIASDQYGNYLIQQIIQLGQPAEKNLVITHIKKHMVSLRGSKYGQKVAYLVEKWNSQKQVSSVINYNCNTDL
Protein: sphingomyelin phosphodiesterase (EC 3.1.4.12) (B1B5D9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Sphingomyelin phosphodiesterase 4
- Sphingomyelin phosphodiesterase 2
- Sphingomyelin phosphodiesterase
- Galactosylceramidase b.
- sphingomyelin phosphodiesterase
- Ceramide kinase
- Ceramide synthase 6
- Galactocerebrosidase
- Ceramide kinase family protein
- UDP-glucose ceramide glucosyltransferase.
Sequence:
MVLHTSPYPSAFLSFLSGLSWAFVFPCYWLLDRLLASCVATSLEKRRRSQDPCSFLALGVLISTPLYLVLLLASLPFAFIGFLLWAPLQSIRKPYIYSHQKPDKHGVEQGSAAGTGAALAEWRPQGRSFCFGSANVCLLPDSLARFNNLADTQRRAREVGKRIRNGASRPQIKIYIDSPTNTSISAVSFCSLSTQGFRRTSSLDHRPDPVVTTENETEALTECPIHTSGGTSSDCPIHSTGVQNSSECPLHPNEEEHAPDCAMHQSSDSECPVHSNIMQNSEDCPLHPSGVQISITSPDSEPAEAEKGNHQTGDGDTGSLDSRTASRESLVRFHAADGGISPNNTLSQHRTSVFKRPIGRKRRHGDDGFDHEISAFFPANLDFLCLQEVFDRRAADRLRRQLHRYFPFVLSDVGRYGWKGCCSRFKFLNSGLLLASRYPILDAHYECFPNGRSEDALAAKGVLFAKVQVGSSAQDQRVVGYITCTHLHAIEGDAAVRCEQLDMLLEWGAEFRRVTSCPADEEKVLEDQVAFDVILGDLNFDNCSSEDKLEQQHSLFTHYKDPCRLGPGEDKPWALGTYLDTSGIYDEEVSSPESLQKVMENEEGRKEYLVFPTSKNHCPSQKGRKIPLKGNGRRIDYILYKEEGLHQDWKVDIEEFSFITQLAGLTDHLSVAARLVVSTGEEET
Protein: ALBINO3-like protein 3, mitochondrial (Q0WUC5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably required for the insertion of integral membrane proteins into the mitochondrial inner membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:25732537}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 6
- Intermediate cleaving peptidase 55, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 5
- Large ribosomal subunit protein mL45
- Mitochondrial intermediate peptidase, mitochondrial
- AT2G34250 protein
- F9K20.24 protein
- SecY protein transport family protein
Sequence:
MAFRRVLLSHLRRSHHTCSSLSPHHVSATTQPSIALALFQSRFFSTPSDLDSELTRFRDDSIAGVGSNDHGLEFDDSIASLGSNGHGLEFGDSIGSLGSNGYGLEFGDLSQDLSNYDYLTQPVISLLDSYHDITGLPWWVVIATSTVAFRTALLPILILQRKQTKRISQFLPKLPHFWPPQGSGRSVLDQLKLFRKERKDIGCPSFLWVPAYFSIQISCFFLWITSIRRMSLDHHPGFDSGGALWFQNLTEIPNGLYGPLFPFLIAGLHYTNTQITFTASSVHKVDKFTELAKAYKTFLNLLTCALYFLSFQMPQGSLLYWATNLSFSIAQQSILNHPVVSAKLGLQANDSVQKEAGNPILTNINEGKLTDPSSKGRLISVHNLTPKELVALSAKYLSGGHKDKSIPLLRLALEKDPEYLQAMIILGQALYQKDQFAEAAKCLEQAASKLLDTSPTEVEEVDLLIVASQWAGVSNIRQGKTSEGITHLERVANMKEPDDPKSKAHYLDALVLYSSAIFNEGRREEAAKYLRRVVAYDPSFSELLKQCEEDDTIPTSSSSNSTSKTS
Protein: Outer membrane protein 41 (Omp41) (PG32) (Q9S3R9)
Organism: Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Function: May have porin activity and function in peptidoglycan binding.
Subcellular location: Cell outer membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Outer membrane protein 40
- Lipoprotein, putative
- 60 kDa protein
- Lipoprotein, putative
Sequence:
MKVKYLMLTLVGAIALNASAQENTVPATGQLPAKNVAFARNKAGSNWFVTLQGGVAAQFLNDNNNKDLMDRLGAIGSLSVGKYHSPFFATRLQINGGQAHTFLGKNGEQEINTNFGAAHFDFMFDVVNYFAPYRENRFFHLIPWVGVGYQHKFIGSEWSKDNVESLTANVGVMMAFRLGKRVDFVIEAQAAHSNLNLSRAYNAKKTPVFEDPAGRYYNGFQGMATAGLNFRLGAVGFNAIEPMDYALINDLNGQINRLRSEVEELSKRPVSCPECPEVTPVTKTENILTEKAVLFRFDSHVVDKDQLINLYDVAQFVKETNEPITVVGYADPTGNTQYNEKLSERRAKAVVDVLTGKYGVPSELISVEWKGDSTQPFSKKAWNRVVIVRSK
Protein: Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (ENR) (EC 1.3.1.9) (NADH-dependent enoyl-ACP reductase) (Q9ZFE4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity).
Interaction partners:
- 3-oxoacyl-[acyl-carrier-protein] synthase 1
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
- Enoyl-[acyl-carrier-protein] reductase
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Malonyl CoA-acyl carrier protein transacylase
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Beta-ketoacyl-[acyl-carrier-protein] synthase III
- 3-oxoacyl-ACP synthase
- Probable biotin biosynthesis protein bioH
Sequence:
MGFLTGKRALIVGVASKLSIASGIAAAMHREGAELAFTYQNDKLRGRVEEFASGWGSRPELCFPCDVADDSQIEAVFAALGKHWDGLDIIVHSVGFAPGDQLDGDFTAVTTREGFRIAHDISAYSFIALAKAGREMMKGRNGSLLTLSYLGAERTMPNYNVMGMAKASLEAGVRYLAGSLGAEGTRVNAVSAGPIRTLAASGIKSFRKMLAANERQTPLRRNVTIEEVGNAGAFLCSDLASGISGEILYVDGGFNTTAMGPLDDD
Protein: RE26528p (Q8SWS3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO07425p1
- Cuticular protein 64Ad
- RE49895p
- RE15373p
- Cuticular protein 65Ea
Sequence:
MFAKIVLVALCVASAQAGLLPFHAPAPLAAPLAPAFAAPLAAPVATAGVVAPYASSFNAHRINHAVAYPVAPAPAPVAFAAPLPAPLPVPVAAPAPVAFAAPAPLPVAAAPAPVAFAAPAKVAFAAPAPVAAPLGFAPAPAPVAFAAPAKFGFGPFAAPLAAPVPAPLAVAPKFAPAPYFF
Protein: FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) (P52734)
Organism: Mus musculus (Mouse)
Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12913069}. Cell projection, lamellipodium {ECO:0000269|PubMed:12913069}. Cell projection, ruffle {ECO:0000269|PubMed:12913069}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12913069}. Note=Associated with membrane ruffles and lamellipodia.
Interaction partners:
- Cell division control protein 42 homolog
- FYVE, RhoGEF and PH domain-containing protein 3
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Src substrate cortactin
Sequence:
MHGHRVPGGPGPSDPERSAANTPGAAPLACADSDPGALEPGLPVSRGSGTALGGPLDPQFVGPSDASLGAPPSSRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPGQSLEPHPEGPQRLRSDPGPPTEIPGPRPSPLKRAPGPKPQVPPKPSYLQMPRVLPPPEPIPPPPSRPLPADPRVAKGLVPRAEASTSSAAVSSLIEKFEREPVIVASDRPAPGPCPVPPEPAMLPQPPPQPTGSQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPIHSLCPGPPALASMPVALADPHRPGSQEVDSDLEEEEEEEEEEKEREIPVPPMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNMPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNRDDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLIYDNNRSNRVCTDCYVALHGAPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDKEMEETPVAASGATAEPPEASQTRDKT
Protein: Mucin-1 (A0A0C4DGW3)
Organism: Homo sapiens (Human)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004247}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004247}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTPGTQSPFFLLLLLTVLTVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAVSMTSSVLSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTSVPVTRPALGSTTPPAHDVTSAPDNKPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDNRPALGSTAPPVHNVTSASGSASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSDTPTTLASHSTKTDASSTHHSTVPPLTSSNHSTSPQLSTGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQIYKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVSVSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPARDTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAATSANL
Protein: STAGA complex 65 subunit gamma (Adenocarcinoma antigen ART1) (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like) (O94864)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:11564863}.
Interaction partners:
- Transcription initiation factor TFIID subunit 10
- Transcriptional adapter 1
- Transcription initiation factor TFIID subunit 9
- Transformation/transcription domain-associated protein
- Transcription initiation protein SPT3 homolog
- Transcription factor SPT20 homolog
- TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
- TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
- Transcription initiation factor TFIID subunit 12
- Histone acetyltransferase KAT2A
Sequence:
MNLQRYWGEIPISSSQTNRSSFDLLPREFRLVEVHDPPLHQPSANKPKPPTMLDIPSEPCSLTIHTIQLIQHNRRLRNLIATAQAQNQQQTEGVKTEESEPLPSCPGSPPLPDDLLPLDCKNPNAPFQIRHSDPESDFYRGKGEPVTELSWHSCRQLLYQAVATILAHAGFDCANESVLETLTDVAHEYCLKFTKLLRFAVDREARLGQTPFPDVMEQVFHEVGIGSVLSLQKFWQHRIKDYHSYMLQISKQLSEEYERIVNPEKATEDAKPVKIKEEPVSDITFPVSEELEADLASGDQSLPMGVLGAQSERFPSNLEVEASPQASSAEVNASPLWNLAHVKMEPQESEEGNVSGHGVLGSDVFEEPMSGMSEAGIPQSPDDSDSSYGSHSTDSLMGSSPVFNQRCKKRMRKI
Protein: GPI-anchored protein LORELEI (B3GS44)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Female gametophyte-specific component of the signaling pathway required for fertilization. Required for reception of the pollen tube by the female gametophyte. Acts specifically at the synergid cell surface for pollen tube reception. Plays a role in double fertilization and early seed development. Component of the FER-regulated Rho GTPase signaling complex. Acts as a chaperone and coreceptor for FER. Required for localization of FER to the plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27081182}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:27081182}. Note=Localized to the filiform apparatus of the synergid cell. {ECO:0000269|PubMed:27081182}.
Interaction partners:
- Receptor-like protein kinase ANXUR1
- Protein RALF-like 1
- Rapid alkalinization factor 23
- Receptor-like protein kinase HERK 1
- Receptor-like protein kinase ANXUR2
- MLO-like protein 7
- Receptor-like protein kinase THESEUS 1
- Ferritin-4, chloroplastic
- Receptor-like protein kinase FERONIA
- Transcription factor MYB97
Sequence:
MELILLFFFLMALLVSLSSSSSISDGVFESQTSVSGRNLRHAKKKCEVNFEYMDYKVLTKRCKGPAFPAKECCSAFKEFACPYVSQINDMNSDCAQTMFSYMNIYGNYPTGLFANECRERKDGLVCPLPPLYSHNLNASTADSTPRFISLLISAATAVFALLVLT
Protein: Taraxerol synthase (KdTAS) (EC 5.4.99.35) (E2IUA6)
Organism: Kalanchoe daigremontiana (Devil's backbone) (Bryophyllum daigremontianum)
Function: Oxidosqualene cyclase that generates taraxerol, a triterpenoid product. Taraxerol is probably required to coat the leaf exterior as a defense compound against pathogens or herbivores.
Interaction partners:
Sequence:
MSFVWVEESKECSEQRKGSMWKLKIAQGGKDPYLYSTNNYVGRQTWEFDPEAGTPEERAEVEAARLNFYNNRYRVKPSADLLYRMQFLKEKNFKQTIPPVKVEDGEEITYETATTALKRAVHFYSALQASDGHWPAENSGPLFFLPPLVMCLYITGHLNTVFPAEHQREILRYIYYHQNEDGGWGLHIEGHSTMFCTALSYICMRILGEGPDGGLDNAVARGRKWILDHGTVTAMPSWGKTWLSIMGLFDWSGSNPMPPEFWLLPSFLPMYPAKMWCYCRMVYMPMSYLYGKRFVGPITPLILQLREELYDQPYEQVNWKQVRHECAKEDIYYPHPKIQDLLWDTLYIAIEPLLTRWPFNKLVRERALQRTMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLARVPDYIWVAEDGMKMQSFGSQQWDTGFAIQALLASNMSDEIGETLAKGHDFVKKSQVKDNPSGDFKSMHRHISKGSWTFSDQDHGWQVSDCTAEGLKCCLLFSLMPPELVGEKMEPERLYDSVNILLSLQSKNGGLAAWEPAGAPEWLELLNPTEFFADIVIEHEYVECTASAIQALVLFKKLYPGHRKKDIETFIKGAAQYIEDRQMPDGSWYGSWGVCFTYGTWFALGGLAAAGKNYDNCAAIRKGTEFLLNTQCENGGWGESYRSCPEKRYVPLEENKSNLVHTAWALMGLIHSRQAERDITPLHRAAKLLINSQLENGDFPQQEITGVFMKNCMQHYAAYRNIYPLWGIAEYRKQIPLPLR
Protein: Serine/threonine-protein kinase WNK2 (AtWNK2) (EC 2.7.11.1) (Protein kinase with no lysine 2) (Q8S8Y9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates flowering time by modulating the photoperiod pathway. Possesses kinase activity in vitro.
Interaction partners:
- Phosphatidate cytidylyltransferase, mitochondrial
- Two-component response regulator-like APRR3
- RNase H domain-containing protein
Sequence:
MNGEESFVEDCSVFVEIDPSGRYGRYDEILGKGASKTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAVRCVGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNMDGFVMRPIDYYNGYDETGVFLRHPLIDDPLYHDQFESSQICEIDLFANDDEDHVDISIKGKRNGDDGIFLRLRISDAEGRIRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWKNDTESSQNVNNNKNNNTAGFCGECASNGYIQETVSSGEKSHHNHHEFDSSEDKSCSSVHGRFADMWGLRESYSDDGEKQSSRKVRSGRWSENEMRRELRWLKARHKIQLMKMRGQTICETPIEISLTPGTSVSLPLLYRAISLPVDAVDM
Protein: CG1740 protein (Q6WAR9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU369002}. Nucleus {ECO:0000256|RuleBase:RU369002}.
Interaction partners:
Sequence:
MSLNPQYEDIGKGFVQQYYAIFDDPANRANVVNFYSATDSFMTFEGHQIQGAPKILEKVQSLSFQKITRVITTVDSQPTFDGGVLINVLGRLQ
Protein: Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP) (Q99541)
Organism: Homo sapiens (Human)
Function: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
Subcellular location: Membrane {ECO:0000250|UniProtKB:P43883}; Peripheral membrane protein {ECO:0000250|UniProtKB:P43883}. Lipid droplet {ECO:0000269|PubMed:34077757, ECO:0000305|PubMed:26357594}.
Interaction partners:
- Butyrophilin subfamily 1 member A1
- Heat shock cognate 71 kDa protein
- Butyrophilin subfamily 2 member A2
- Butyrophilin subfamily 2 member A1
- Butyrophilin-like protein 9
- Erythroid membrane-associated protein
- Butyrophilin-like protein 3
- Butyrophilin subfamily 3 member A3
- Butyrophilin-like protein 8
- Butyrophilin subfamily 3 member A2
Sequence:
MASVAVDPQPSVVTRVVNLPLVSSTYDLMSSAYLSTKDQYPYLKSVCEMAENGVKTITSVAMTSALPIIQKLEPQIAVANTYACKGLDRIEERLPILNQPSTQIVANAKGAVTGAKDAVTTTVTGAKDSVASTITGVMDKTKGAVTGSVEKTKSVVSGSINTVLGSRMMQLVSSGVENALTKSELLVEQYLPLTEEELEKEAKKVEGFDLVQKPSYYVRLGSLSTKLHSRAYQQALSRVKEAKQKSQQTISQLHSTVHLIEFARKNVYSANQKIQDAQDKLYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLLSNIQGVPQNIQDQAKHMGVMAGDIYSVFRNAASFKEVSDSLLTSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQNAQDQGAEMDKSSQETQRSEHKTH