wanglab/gogpt-training-data huggingface dataset:
Protein: Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial (EC 2.1.1.320) (Mitochondrial dysfunction gene A) (NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 homolog) (Q54S83)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts as an arginine methyltransferase and probably acts by mediating arginine methylation of ndufs2 (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16507593}.
Interaction partners:
- NADH-ubiquinone oxidoreductase 49 kDa subunit
- ATP synthase F
- NADH-ubiquinone oxidoreductase 23 kDa subunit
Sequence:
MFRSITQRVIRNNCYKQSTKSITSSTSFINNSLSYTTTSNENDIKDKNEEHDHRAKGKGRELLLSFDKSGLAQFPKQVFKNRKYPITDFEKYLQDITKVRGPMSIDTFIKEVLTNPKYGYYMNKDVFGKGGDFITAPEVSQLFGEMIGIWCVATWEAMGKPKKLQIVEMGPGRGTLMKDILRSTKVFKEFYDSISVHLVEASPANKKTQKQNLLYFKDKAINFDHKTIGETPNGIKVTWVGKLEEVPTDIPTLFLAQEFFDALPIHVFRFSREKNDWCEVLVDEDITEHGEYYLRFVQSKGPTLMTTAVKHLLPEFGLDGYQVELGLAGLAISQQIANRIDKSGGAALIIDYGYDKIVKSSLQAIRDHEFVDILDKPGTADLSVWVDFQTIRKTVKLLKNKSTAIGPVDQGIFLKEMGIEHRLAQIGRKLDSNEKFEELVMGYKKLVDPKEMGTNYKVITICDKNITPIGFSTSKTYDDEDLMI
Protein: Receptor-like protein kinase FERONIA (EC 2.7.11.1) (Protein SIRENE) (Q9SCZ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor-like protein kinase that mediates the female control of male gamete delivery during fertilization, including growth cessation of compatible pollen tubes ensuring a reproductive isolation barriers, by regulating MLO7 subcellular polarization upon pollen tube perception in the female gametophyte synergids. Required for cell elongation during vegetative growth, mostly in a brassinosteroids- (BR-) independent manner. Acts as an upstream regulator for the Rac/Rop-signaling pathway that controls ROS-mediated root hair development. Seems to regulate a cross-talk between brassinosteroids and ethylene signaling pathways during hypocotyl elongation. Negative regulator of brassinosteroid response in light-grown hypocotyls, but required for brassinosteroid response in etiolated seedlings. Mediates sensitivity to powdery mildew (e.g. Golovinomyces orontii). Positive regulator of auxin-promoted growth that represses the abscisic acid (ABA) signaling via the activation of ABI2 phosphatase. Required for RALF1-mediated extracellular alkalinization in a signaling pathway preventing cell expansion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17673660, ECO:0000269|PubMed:21071669, ECO:0000269|PubMed:24458638, ECO:0000305|PubMed:17644812}; Single-pass type I membrane protein {ECO:0000269|PubMed:17673660, ECO:0000269|PubMed:21071669, ECO:0000269|PubMed:24458638, ECO:0000305|PubMed:17644812}. Note=Accumulates asymmetrically in the female gametophyte synergid membrane at the filiform apparatus.
Interaction partners:
- GPI-anchored protein LLG2
- Rapid alkalinization factor 23
- Probable methyltransferase PMT19
- GPI-anchored protein LORELEI
- Protein RALF-like 1
- AT4g00280 protein
- Pollen-specific leucine-rich repeat extensin-like protein 4
- Ferritin-4, chloroplastic
- Kunitz trypsin inhibitor 3
- Interleukin-1 receptor-associated kinase 4 protein
Sequence:
MKITEGRFRLSLLLLLLLISAATLISAADYSPTEKILLNCGGGASNLTDTDNRIWISDVKSKFLSSSSEDSKTSPALTQDPSVPEVPYMTARVFRSPFTYTFPVASGRKFVRLYFYPNSYDGLNATNSLFSVSFGPYTLLKNFSASQTAEALTYAFIIKEFVVNVEGGTLNMTFTPESAPSNAYAFVNGIEVTSMPDMYSSTDGTLTMVGSSGSVTIDNSTALENVYRLNVGGNDISPSADTGLYRSWYDDQPYIFGAGLGIPETADPNMTIKYPTGTPTYVAPVDVYSTARSMGPTAQINLNYNLTWIFSIDSGFTYLVRLHFCEVSSNITKINQRVFTIYLNNQTAEPEADVIAWTSSNGVPFHKDYVVNPPEGNGQQDLWLALHPNPVNKPEYYDSLLNGVEIFKMNTSDGNLAGTNPIPGPQVTADPSKVLRPTTRKSKSNTAIIAGAASGAVVLALIIGFCVFGAYRRRKRGDYQPASDATSGWLPLSLYGNSHSAGSAKTNTTGSYASSLPSNLCRHFSFAEIKAATKNFDESRVLGVGGFGKVYRGEIDGGTTKVAIKRGNPMSEQGVHEFQTEIEMLSKLRHRHLVSLIGYCEENCEMILVYDYMAHGTMREHLYKTQNPSLPWKQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPTLDHTHVSTVVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEALCARPALNPTLAKEQVSLAEWAPYCYKKGMLDQIVDPYLKGKITPECFKKFAETAMKCVLDQGIERPSMGDVLWNLEFALQLQESAEENGKGVCGDMDMDEIKYDDGNCKGKNDKSSDVYEGNVTDSRSSGIDMSIGGRSLASEDSDGLTPSAVFSQIMNPKGR
Protein: Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (O74864)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL29
Sequence:
MAISKESKAQYFEKLRSLFEKYNSLFVVNIDNVSSQQMHTVRKQLRGTAELIMGKNTMIRRAMRGIINDMPELERLLPVVRGNVGFVFTNADLKEVRETIIANVIAAPARPNAIAPLDVFVPAGNTGMEPGKTSFFQALGIPTKITRGTIEITSDVHLVSKDAKVGPSEATLLNMLNISPFTYGMDVLTIYDQGNVFSPEILDVSEEDLIGHLLSAASIITAISLGANYPTILSVMHSVVNAYKNLVAVSLATEYTFEGTEQTKAFLADPSAFVVAAAPAAAAGGEAEAPAAEAAAEEEEESDEDMGFGLFD
Protein: GrpE protein homolog (Q8IIB6)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Mitochondrion matrix {ECO:0000256|RuleBase:RU000640}.
Interaction partners:
- Heat shock protein 70
- Cytochrome c oxidase subunit 5B, putative
- Mitochondrial import inner membrane translocase subunit TIM44, putative
- Endoplasmic reticulum chaperone GRP170
- ATP-dependent protease, putative
- Heat shock 70 kDa protein
- Heat shock 70 kDa protein
- Endoplasmic reticulum chaperone BIP
- Heat shock protein 110
- 20 kDa chaperonin
Sequence:
MRYSTNIIKKGILSRYCSNIYGMQYIPRARYFLTFCKNEKCNTMLKKYHPFSTSKMSDNAHYKGEDMNKMKNKENKTNKTNKTNEANKANETNETNETIENSASSPTEGKKKKNSLNESEEANEKKEDINYEDFNKIDLINEIKKTKRDMEEKMVDNKVLKEKYLSVLAENENLRNRYMKEIETSKLYCISNFAKSLLDVADNLSLAIKNINEESLKTNEEINNIYKGIEMTETILHNIFNKYGIDKYNPINEKFNPQLHEAIFEINDSTKEKGTVATVIQHGYKIKDRILRAAKVGVVKN
Protein: mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (A0A8I6AEL0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGTEAGEGITFSVPPILSAGFCPIPEGGSCRRGGGAATAAEGEPSLQPLLMPPPPPPPGSFWNVESAAAPGTSCPTTAPGSSATRGRGNSGSGGGRRTTVAYVINEASQGQLVVAESEALQSLREACEAVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTVCTGNYTFIPYMVTPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFVQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEEQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHLRVIQASEKLFRLKTPAWYLKSIVETILIYKHFVKLTTEQPTAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFNASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKRFFEMVNTITEEKGRGAEEGDCEGDSLEYDYEHDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSGMWLHGEEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKADPFSFKTRAKSCGEKDGKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESLAQGPEEPKLKWEHITTLISSLREFVRSTDRKIIATTLSRLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLDVDDEHEESPSNQTARRPQPVAEDAVATSGVSTLSSTVSHDSQNAHRSLNVQLGRMKMETNRLLEELVRKEKELQALLHQAIEEKDQEIKHLRLKSQPIDTPGFPVCHLNAPGTAIEDSELTGWLRENGADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKGA
Protein: AT08919p (Q8T492)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTPNFLLSNGKNMPMLGLGTWRSPPEVVTQAVKDAIDIGYRHFDCAHIYGNEAQVGAALREKMDEGVVTRDELFITSKLWNTHHKPDLVRPACETSIRNLGVKYLNLYLMHWPMAYKSGSDNLYPTCPDTNKAAFEDIDYVDTWRAMENLVDEGLCQAIGVSNFNEQQMNRLLSVAKLKPVVLQIECHPYLSQKPLITLCYDNAIAVTAYSCLGSGHTPYEKPGAYPLLQHPTILAIAEKYERTAAQVLLRYQTQSGIIVIPRSVSKQHMLDNFKRIWDFELAVDDIQAINELDCNGRFMTMKAAYGHPHHPFEPKAKVDN
Protein: Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2 (AS) (EC 4.1.3.27) (Anthranilate synthase, glutamine amidotransferase component); Indole-3-glycerol phosphate synthase (IGPS) (EC 4.1.1.48); N-(5'-phosphoribosyl)anthranilate isomerase (PRAI) (EC 5.3.1.24)] (Q92370)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.
Interaction partners:
- Putative aminodeoxychorismate synthase
- Anthranilate phosphoribosyltransferase
- Probable anthranilate synthase component 1
- Tryptophan synthase
- Chorismate synthase
- Chorismate mutase
- Histidinol-phosphate aminotransferase
- Dihydroorotate dehydrogenase
- 3-isopropylmalate dehydratase
- Adenylosuccinate synthetase
Sequence:
MSEKVDVGESVKGDASENAVKEVAERPIVMIDNYDSFTWNVVQYLSNLEKRYPIMVFRNDEITVDELEKLNPLKLVLSPGPGHPARDGGICNEAISRFAGKIPILGVCMGLQCIFETMGGKVDSAGEIIHGKVSKINHDGLGFYQGIPQNISVTRYHSLAGKISSLPDCLDVTSWTENGVIMGARHKKYAIEGVQYHPESILSEYGKEYIQNFLNLTAGTWEENGIVMPTKNNAFNAAMRENSNSVSSTKIRKQESILEKIHAQRLIDIAESKRKPGLSVGDLQTYLNLNIAPPCINFYERLKQSKPALMAEVKRASPSKGDIKLDANAAIQALTYAQVGASVISVLTEPKWFKGSLNDLFVARKAVEHVANRPAILRKDFIIDPYQIMEARLNGADSVLLIVAMLSREQLESLYKFSKSLGMEPLVEVNCAEEMKTAIELGAKVIGVNNRNLHSFEVDLSTTSKLAEMVPDDVILAALSGISSPADVAHYSSQGVSAVLVGESLMRASDPAAFARELLNLSSSEISNGKKTSTPLVKVCGTRSLLAAKTIVESGGDLIGLIFVEKSKRKVDLSVAKEISHFVHTTNRKHISPKKAVTGQSWFDHQYENLASSPHPLLVGVFQNQPLEYIRSIIAEVNLDIVQLHGQEPFEWIHMLDRPVIKVFPLNSSEISRPNYHIVPLIDAYVGGESGGLGKKVDWEAASFIPVSYVLAGGLTPKNVQDAISVSRPAVVDVSSGVETDGKQDLEKIKAFINAVKEL
Protein: Putative MacA (Q2EHL9)
Organism: Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Subcellular location: Cell envelope {ECO:0000256|ARBA:ARBA00004196}.
Interaction partners:
Sequence:
MKKKPLIITAIAAAVITGGYFFVRDSSAQTTYLTEEVKRGNIEKNVVATGSIESINTVDVGAQVSGKVTKLYVKLGQQVKKGDLIAEIDSTTQINTLNTRKAALASYQAQLVARKTAYDVALSNYNRLSKLYGQKATSLDTLNTAKATLNNAKAEMDVVQENIKQAEIEVNTAETNVGYTKITSPIDGTVISTPVSEGQTVNSNQTTPTIIKVADLSKMRIKPEISEGDITKVKAGQDVTFTILSDNKTVYHAKIDSVDPATTTISDNSSSNSSSSGSSSSSGSSSSAVYYYANIIVENPEHVLRIGMTTENNIKIADVQNVLFIPNLAVQKQQDKYVVNVLNGNTTQEREIEIGVQNDFQTEVKSGLTEGEKVVISQVAAGETFGDPDAPIIF
Protein: Sodium vitamin C co-transporter 2 (Solute carrier family 23 member 2) (B9VMA9)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Trifunctional purine biosynthetic protein adenosine-3
- OMPdecase domain-containing protein.
- Chromosome 18 open reading frame 21.
Sequence:
MQVHDILETMGIGKNTTSKSVEAGGSTEGKYEDESKHPTFFTLPVVINGGATSSGDQDTEDTELMAIYTTENGIAEKSSLAETLDSTGSLDAQRTDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGFDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLEKWKCNNTDITVTNGTTELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLRYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYRLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSSKYGFYARTDARRGVLLVAPWFKVPYPFQWGLPTISAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFIEGLSCVLDGVFGTGNGSTSSSPNIGVLGITKVGSRRVIQYGAAFMLLLGMVGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLKQNPLVTGIAGIDQVLNVLLTTAMFVGGCVAFILDNTIPGSPEERGIRKWKKGVGKGSKSLEGMETYDLPFGMNFIKKYRCFSFLPISPTFMGYTWKGFRKSSNCRSSDEDSEATV
Protein: Protein Wnt-16 (Q9UBV4)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Protein-serine O-palmitoleoyltransferase porcupine
- Wnt inhibitory factor 1
- Palmitoleoyl-protein carboxylesterase NOTUM
- Frizzled-6
- Low-density lipoprotein receptor-related protein 5
- Glypican-3
- Frizzled-4
- Frizzled-1
- Secreted frizzled-related protein 1
- Frizzled-2
Sequence:
MDRAALLGLARLCALWAALLVLFPYGAQGNWMWLGIASFGVPEKLGCANLPLNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTAPMGASPLFGYELSSGTKETAFIYAVMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIGNTTGKENKVLLAMNLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIHKDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK
Protein: DNA excision repair protein ERCC-1 (AtERCC1) (AtRAD10) (EC 3.1.-.-) (Ultraviolet hypersensitive 7) (Q9MA98)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5' to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA-damage sensitive cell-cycle checkpoint during the G2 phase.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA repair endonuclease UVH1
- Crossover junction endonuclease MUS81
- AT5G65740 protein
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB1
- DEAD-box ATP-dependent RNA helicase FANCM
- Crossover junction endonuclease MUS81
- DNA repair protein UVH3
- DNA mismatch repair protein MSH2
- General transcription factor IIH subunit 2
Sequence:
MANEDDDGEKSRSLHQQIARKPKTQIVIGVPSYQEVLESSQTKSTPPSLFKPSQSFSQAFAFVKSSDVYSPPPPSSAAASSSQPSGASQVPHSSSQTHQTDGASSSSTPVATGSVPSNTTQNRNAILVSHRQKGNPLLKHIRNVKWVFSDIIPDYVLGQNSCALYLSLRYHLLHPDYLYFRIRELQKNFKLSVVLCHVDVEDTVKPLLEVTKTALLHDCTLLCAWSMTECARYLETIKVYENKPADLIQGQMDTDYLSRLNHSLTSIRHVNKSDVVTLGSTFGSLAHIIDASMEDLARCPGIGERKVKRLYDTFHEPFKRATSSYPSVVEPPIPEAPVEKDVNSEEPVEEDEDFVEDSRKRKKKEPEPEKTVKTALSAVFARYSDRLSKKKEKQKEKDTTTASDAETHQN
Protein: Origin recognition complex subunit 1 (Q7ZYW6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365058}.
Interaction partners:
Sequence:
MSRYITRLSMRRTYKWNGRPVGEDRKLRRQYYGSMSISVDGRTEDVTVSLGQYILIEGENDDNPYVAQLLKLYTDGKMKTAVVQWFVRICEVPQYKRKLLGRDPHPQEVFFYQDSSCDNEVDGESILAPVQIMYIAPEHPFPEGKSKDMLFVKHSWDTKSFQAVDPELIEPPPSPKSPPPSSRGPQARPLPTPDPSIMKRAITGAITRGSMSTGKMSSTEAESLHSASKLSAAKALSAKRRSRASSGPHVRKKLELCSPSKNMSRDDVLGEILDKHIDTDKTLMSKINSSPSGRISISIRLTPVKCNEEQQILPLSSHSPDKPTLTAYGSDSATSVFLGVPALGDDDSESLNNTGRTPRKREATPRRASVRGLKARTPSRRKDSASLKEPALTALAEEEHEDSPAQTAATPRSKRKSAQLVSSRIRKQLNLIANKFDLQSDGEDGDEDDCFVPSKIDLQSSSDEELEAKVDSEDELVVKKRRGSRTPRATDKSCVSARTPCKTPSKKAAPSTPRTPRHATPSIPSRTAPARKPGNVLEEARARLHVSAVPESLPCREQELQDIYNFVESKVIDGTGGCMYISGVPGTGKTATVHEVIRSLQQSAEQDEIPHFNFIEINGMKMTDPHQAYVQILQKLTDQKATSDHAAALLEKRFSAPAPKKETTVLLVDELDLLWTRKQNVMYNLFDWPTRRNARLVVLTIANTMDLPERIMINRVASRLGLTRMSFQPYTFKQLQQIITSRLNRVKAFEEDALQLVSRKVAALSGDARRCLDICRRATEICEHSGNQQKGSGLVGMSHVMEALDEMFSSSYIAAIRSASVQGQLLLRAVIAEFRRLGLEEATFQQVFVQHQALCRVEGLQPVSVSEGLLVCQRLGSCRLLLLEGSRLDLFLRIRLNVSQDDVLYALKAD
Protein: Recoverin (p26) (P21457)
Organism: Bos taurus (Bovine)
Function: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin. Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity).
Subcellular location: Photoreceptor inner segment {ECO:0000269|PubMed:1672047}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:1454850, ECO:0000269|PubMed:1672047, ECO:0000269|PubMed:1672637, ECO:0000269|PubMed:17015448}. Photoreceptor outer segment membrane {ECO:0000269|PubMed:1454850}; Lipid-anchor {ECO:0000269|PubMed:1454850}; Cytoplasmic side {ECO:0000269|PubMed:1454850}. Perikaryon {ECO:0000250|UniProtKB:P34057}. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (PubMed:17015448). {ECO:0000250|UniProtKB:P34057, ECO:0000269|PubMed:17015448}.
Interaction partners:
- Rhodopsin kinase GRK1
- Rhodopsin
- Rhodopsin kinase GRK7
- Cone-rod homeobox protein
- Visual system homeobox 2
- Photoreceptor-specific nuclear receptor
- Paired box protein Pax-6
- Calbindin
- Arrestin-C
- Orthodenticle homeobox 2
Sequence:
MGNSKSGALSKEILEELQLNTKFTEEELSSWYQSFLKECPSGRITRQEFQTIYSKFFPEADPKAYAQHVFRSFDANSDGTLDFKEYVIALHMTSAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVTAIFKMISPEDTKHLPEDENTPEKRAEKIWGFFGKKDDDKLTEKEFIEGTLANKEILRLIQFEPQKVKEKLKEKKL
Protein: Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) (P10632)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form. Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1). Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol).
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 3A4)
- Bifunctional epoxide hydrolase 2
- Cytochrome P450 3A7
- Cytochrome P450 4A11
- Peptidyl-prolyl cis-trans isomerase G
- Cytochrome P450 3A5
- Cytochrome P450 1A1
- Cytochrome P450 4F2
- Cytochrome P450 2E1
- Aldehyde oxidase
Sequence:
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
Protein: Glycerol-1-phosphate phosphohydrolase 2 (EC 3.1.3.21) ((DL)-glycerol-3-phosphatase 2) (Hyperosmolarity-responsive protein 2) (P40106)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Glycerol-1-phosphate phosphohydrolase involved in glycerol biosynthesis. Plays a role in osmoadaptation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein YIG1
- Glycerol-1-phosphate phosphohydrolase 1
- Glycerol kinase
- Glycerol 2-dehydrogenase
- NADP-dependent alcohol dehydrogenase 6
- Glycerol-3-phosphate O-acyltransferase 1
- Monoglyceride lipase
- Glycerol-3-phosphate O-acyltransferase 2
- NADP-dependent alcohol dehydrogenase 7
- Dihydroxyacetone kinase 1
Sequence:
MGLTTKPLSLKVNAALFDVDGTIIISQPAIAAFWRDFGKDKPYFDAEHVIQVSHGWRTFDAIAKFAPDFANEEYVNKLEAEIPVKYGEKSIEVPGAVKLCNALNALPKEKWAVATSGTRDMAQKWFEHLGIRRPKYFITANDVKQGKPHPEPYLKGRNGLGYPINEQDPSKSKVVVFEDAPAGIAAGKAAGCKIIGIATTFDLDFLKEKGCDIIVKNHESIRVGGYNAETDEVEFIFDDYLYAKDDLLKW
Protein: ASI1-immunoprecipitated protein 1 (Protein ENHANCED DOWNY MILDEW 3) (Q9LNE8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: [Isoform 1]: Nucleus {ECO:0000269|PubMed:30407670}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:30407670}.
Interaction partners:
- Protein RECOGNITION OF PERONOSPORA PARASITICA 7
- Protein ENHANCED DOWNY MILDEW 2
- Zinc finger protein CONSTANS-LIKE 5
- Protein SGT1 homolog B
Sequence:
MATPEEVAYEKFLERVRRTVYVDELTPLATAPVISSAFNQFGTVKKVSFIPNYLGPKELPMGVLVEMENEEMTQAVISTVSQLPFMVAGMPRPVRACAAEPNMFVDKPKKPGRTVRFRWIKPNDPDFDKARRVKRLARKHSAENSFMLKKQLEEAEKLSKQQAETAVTHHKKFEMMDKLLYDGVAQKLAGRYDLKGFPYR
Protein: PTS system mannose-specific EIIAB component (EC 2.7.1.191) (EIIAB-Man) (EIII-Man) [Includes: Mannose-specific phosphotransferase enzyme IIA component (PTS system mannose-specific EIIA component); Mannose-specific phosphotransferase enzyme IIB component (PTS system mannose-specific EIIB component)] (P69797)
Organism: Escherichia coli (strain K12)
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:2951378, ECO:0000269|PubMed:2999119}. Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:2999119}; Peripheral membrane protein {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:2999119}.
Interaction partners:
- PTS system mannose-specific EIIC component
- PTS system mannose-specific EIID component
- Phosphocarrier protein HPr
- Mannose-6-phosphate isomerase
- Phosphomannomutase
- PTS system glucose-specific EIICB component
- N-acetylgalactosamine permease IIC component 1
- N-acetylgalactosamine permease IID component
- Fructokinase
- Putative phosphotransferase enzyme IIA component YadI
Sequence:
MTIAIVIGTHGWAAEQLLKTAEMLLGEQENVGWIDFVPGENAETLIEKYNAQLAKLDTTKGVLFLVDTWGGSPFNAASRIVVDKEHYEVIAGVNIPMLVETLMARDDDPSFDELVALAVETGREGVKALKAKPVEKAAPAPAAAAPKAAPTPAKPMGPNDYMVIGLARIDDRLIHGQVATRWTKETNVSRIIVVSDEVAADTVRKTLLTQVAPPGVTAHVVDVAKMIRVYNNPKYAGERVMLLFTNPTDVERLVEGGVKITSVNVGGMAFRQGKTQVNNAVSVDEKDIEAFKKLNARGIELEVRKVSTDPKLKMMDLISKIDK