Protein: Tetraspanin-14 (H2L006)
Organism: Caenorhabditis elegans
Function: Together with tsp-12, regulates cell fate specification in the postembryonic mesodermal M lineage, body size and male development, probably by positively modulating BMP-like Sma/Mab signaling. Together with tsp-12, probably acts by modulating the activation of glp-1, Notch-like receptor, to regulate germline maturation.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:31988138}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Endosome membrane {ECO:0000269|PubMed:31988138}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Early endosome membrane {ECO:0000269|PubMed:31988138}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Late endosome membrane {ECO:0000269|PubMed:31988138}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Recycling endosome membrane {ECO:0000269|PubMed:31988138}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Note=Often in close juxtaposition to the retromer but not part of it, suggesting separate microdomains of the same endosome. {ECO:0000303|PubMed:31988138}.; SUBCELLULAR LOCATION: [Isoform a]: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:35089916}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Endosome membrane {ECO:0000269|PubMed:35089916}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Early endosome membrane {ECO:0000269|PubMed:35089916}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Late endosome membrane {ECO:0000269|PubMed:35089916}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Apical cell membrane {ECO:0000269|PubMed:35089916}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Note=Primarily localised to intracellular vesicles. {ECO:0000269|PubMed:35089916}.; SUBCELLULAR LOCATION: [Isoform b]: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:35089916}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Endosome membrane {ECO:0000269|PubMed:35089916}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Recycling endosome membrane {ECO:0000303|PubMed:35089916}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Basolateral cell membrane {ECO:0000269|PubMed:35089916}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Note=Primarily localised to the cell surface. {ECO:0000269|PubMed:35089916}.
Interaction partners:
- Disintegrin and metalloproteinase domain-containing protein 10 homolog
- Tetraspanin-15
- Tetraspanin
- Tetraspanin
- Tetraspanin
- Tetraspanin
- Tetraspanin
- Serine/threonine-protein kinase receptor sma-6
- Tetraspanin
- Tetraspanin
Sequence:
MPHRAPRRFMKTAPGACDWEQCLLMGSGEPTRARAVVSSSHKQRKPRQEISACLKWLVFLLNSIVFLVGVGILALGVYLFIKDFREVKLVDIILNPAILISIFGFSICVVSFFGFMGALRDNIFLLKCFAACVFLSYILVVAVTLVFFTLFYTDTTEGLSANWLLLYAVKNYHTNRNLAEIMDALQENLECCGVSSIAQGYRDWNMSYQFNCTNSNPQPEKCGVPFSCCRKSVISEAAGSSNPLLPAMRSLECWQNALTKRPGDLEHDIYTRGCLQPLRTLFESHAVHVGAFVALLIVPVCISVCLTNILAKQVDHQRYLLEREARRNDRRRKRDHNRRDQLNSLDLLEEGKFNNASANATRPRPPDIPPPLPPIEHVPRKKSRNASSSPTRKPKSAGVENAAARRKRTATTTRTPPAAAGPAPTPQATTTNRTHQWVLQQTDLVPQKSKS