wanglab/gogpt-training-data huggingface dataset:
Protein: P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor) (P49654)
Organism: Rattus norvegicus (Rat)
Function: Receptor for ATP that acts as a ligand-gated cation channel. Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:7566119, ECO:0000269|PubMed:7566120}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=Localizes to neuronal cell body of sensory neurons. {ECO:0000269|PubMed:9721930}.
Interaction partners:
- P2X purinoceptor 2
- P2X purinoceptor 6
- P2X purinoceptor 1
- P2X purinoceptor 4
- P2X purinoceptor 5
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2A
- Transient receptor potential cation channel subfamily V member 1
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor ionotropic, NMDA 2D
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDSQCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEEVTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH
Protein: DNA mismatch repair protein MutL (P23367)
Organism: Escherichia coli (strain K12)
Function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA.
Interaction partners:
- DNA mismatch repair protein MutH
- DNA helicase II
- DNA mismatch repair protein MutS
- Beta sliding clamp
- DNA mismatch endonuclease Vsr
- DNA polymerase I
- ATP-dependent DNA helicase RecQ
- Protein RecA
- tRNA dimethylallyltransferase
- UvrABC system protein B
Sequence:
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGRNHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKLKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVCAQPLLIPLRLKVSAEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE
Protein: Histone H2B (Q384T0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000451}.
Interaction partners:
- Histone H2A
- Histone H3 variant
- Histone H3, putative
- Histone H4
- Histone H4
- Histone H2A
- Cell division control protein 73 C-terminal domain-containing protein
- SET domain-containing protein
- Plastid-encoded RNA polymerase subunit alpha
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
Sequence:
MPPTKGGKRPLPLGGKGKGKRPPGQTTKSSSSRKKSGARRGKKQQRWDLYIHRTLRQVYKRGTLSKAAVRVLSSFIEDMYGKIQAEAVHVACINNVKTLTAREIQTSARLLLPPELAKHAMSEGTKAVAKYNASREEAYSKVL
Protein: [F-actin]-monooxygenase mical2b (EC 1.14.13.225) (Molecule interacting with CasL protein 2B) (MICAL-2) (F1RA39)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrtf-a presence in the nucleus and promote srf:mkl1/mrtf-a-dependent gene transcription.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O94851}. Cytoplasm {ECO:0000250|UniProtKB:Q8BML1}.
Interaction partners:
- Kin of IRRE-like protein 3
Sequence:
MGETEEERTSQAGQLFENFIQATTCKGTLQAFSVLCRQLELNPSDHRGFYSSLKTAVTFWKAKGLWGKLDKRAGHKEYSKGRACADTRCLIIGGGPCGFRTAIELALLGAKVVVIEKRDTFSRNNVLHLWPYTIHDLRNLGAKKFYGKFCAGSIDHISIRQLQLMLLKIALIVGVEVHVNVEFVKLLEPPEDQSTDGQGWRAEIRPADNPVSDYEFDVIIGADGRRSTLDGFRRKEFRGKLAIAITANFVNRNTTAEAKVEEISGVAFIFNQKFFLELKEETGIDLENIVYYKDNTHYFVMTAKKQSLLDKGVIINDYIETERLLAFDNVNQEALLSYAREAADFGTNYQLPSLDYAINHYGQPDVAMFDFTCMYASENAALVREKSHRQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMIKGWAQGKEPLDLLSERESIYRLLPQTTAENISKNFEQYTIDPATRYPNLNSSCVRPHQVRHLFISGEQDLSSLERSGQTRRSVSISRRESEVRPGRLLLWCQNQTQDYRGVNVTDLNTSWRSGLALCALIHRQRPELIDFDSLNEADCAKNNQLAFDVAEREFGIQPVTTGKEMDAERGPDKLIMVLYLSKFYEMFHKSTQSVTGLPKEIDANNGDCSSKTANSLYNSINHARKRIPKLDKKLEESDVNRKRKKASSHHEELMSCQTAPPAGEREEQKENKVRSMATQLLARFEENAPSCALRRQSDSESDSDADRPVSLDLTENPRFARPKIEPTHPSTTPDKAKWQPSPYLRLLESNTRSETLHTEHYVESQSSHRLTEIQSECQYSSVSSAYKSSERRPRSPLIPFTPTLSPMMHCLQQLEEQVIQQRKREPLNRKSIKERAQKLSSLFTGNPAQPQTDESSPAVSPSSPPQTIPESSTLSCLLSPAPSLTHKQCSEASETHLKADKHTEIRRVERLDPSKQRTVGKVSSAIGVKAATLAILYETDHRPNNPITLSLTEARRCAESGLVSVRKEFSASLGGSDTCVFCQKRVYIMERLSAEGFFFHRECFRCHICGCSLRLGAHTFDSQQGTFYCKMHFSQRKTSTRHRRGEIQDGGIRSSSITISNHTSTDGTRGQPSGGEFDSSTQQDLQTLPDSKEIISVSEVKDSSKKADPADSAPACPDSPLQKVKRSTAKGEITNKNILWKKKIRSTLPLVLMKKFHRGKPEDKTEVLAEEDGNSDFEEIHESLSSKKPSNPSTDSNCLPTKDNSSTPLDEIPKIPLYRTHVLPEYPKPSSSSPEPIVTSISSDPISFSPKKKLTLSLSEKEKLLNWDLTNPGKSGAEEQQQQHVKPSISLQHDHPEPTHPQPEPAPPLFGFQQWANNLRKSFSKGSNPVVLRRNRPMKARPLSEGSFNVGAVFQDEERCGSLVDEGEARPRTESEIASLLEQVALGSKTSRGTKDDMASLPPRKLNFFSSLRIKRVEGAEQSRGEGQKDILSILSRFRNKASAQQQQQQKSNSSSEDEQEPKLTHSGALQKKKEKIAIRQTKSDELKRLHRAQVIQRQLEEVEEKQRSLEEKGVALEKVLRGENGDDGSTDEAALLQTWFKLVLEKNKLSRYESELMIFAQELELEDTQSRLQQDLRRRMATEDCEKSASELVEEQNILVEIMKVVEKRDKLVSLLEEQRLKEKAEDRDLESLILSRGYQFHWT
Protein: Importin N-terminal domain-containing protein (G5EAZ4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Importin subunit alpha
- Nucleoporin NSP1
- GTP-binding nuclear protein
- Ribosomal RNA-processing protein 8
- H/ACA ribonucleoprotein complex subunit CBF5
- Nonsense-mediated mRNA decay protein
- Peptidase S59 domain-containing protein
- Importin beta-3 subunit, putative
- Nuclear cap-binding protein subunit 2
- mRNA export factor MEX67
Sequence:
MDVTQVLANTISSDANTRSNAEQQLLHAAEVDFAGYLVTLGQELANENSASHIRTAAGLALKNAFTFRDRERLNEVQQKWRQQITPDIKAQVKELALKTLASKDGRAGQSAAQFIVSIAAIELPQNEWPDLMQILVQNVASGSDQMKQASLVTIGFICESQEMELRESLAAHSNAILTAVVQGARREEQNMDIRFAAIKALSDSVDFVRSNMENEGERNYIMQVVCEATQAEDLRVQAGAFGCLNRIMGAYYDKMSFYMEKALFGLSIMGMKSEEEDVAKLAIEFWCTVCEEEIAIEDDNAAAQAEGLTDVRPMYGFARIACREVVPVLLQAMCKQDEDAGDDEYNISRAAYQALQLYAQCVQADVIQPVLAFVEENIRSEDWRRRDAAVAAFGAIMDGPDPKVLEPLVKQALHVLVSMMEDSSIQVRDSAAYALGRVCDFCSETLDPDVHLQPLISCLFNGLASSPKIASSCCWALMNVADRFAGDVGAQTNPISKYFEESVKSLLALTERSDADNQLRTAGYEVLNSFVTNAANDSLPTVAHLSDVVLQRLERTIPMQQQVVSVEDRIMLEEMQTGITSVVLAIVQRLEAEIKPQADRIMQILLQVLSTVPPKSSVPDVVFATVGAIANALEEEFVKYMESFSPFLNGALGNQEEPGLCAMAIGLVSDISRALNEKVLPYCDTFMNHLMNNLSSATNQLKPAILETFGDIAQAIGEHFDKYLTVVGQVLKQASLVTASNDVTIEMLDYIISLREGIMDAWGGILLAYKGKPQAQALKEFIDPIFELLRLISQDPASRSEGLMRASMGVLGDLAETYPDGSISAYFRNEWVTSLVRETRTNREYGQRTIDTARWAREQVKNQINMQGGGMS
Protein: Metallophosphoesterase (A3DJ38)
Organism: Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)
Interaction partners:
- Small RNA 2'-O-methyltransferase
- TROVE domain-containing protein
- RNA 2',3'-cyclic phosphodiesterase
- Nucleotidyltransferase
Sequence:
MKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLVSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQLKKSIKGLQREGFRYVYILNSPEEVEEVVFERQPLWNNKKDEHGPFDIIGDIHGCYDELKMLLEKLGYLIEEVEGGVGSGKYRVTHPEGRKVLFLGDLVDRGPKITEVLKLVMGMVKSGIALCVPGNHDVKLLRKLNGRDVQITHGLDRTLEQLAKEPQEFIEEVKAFIDGLVSHYVLDDGKLVVAHAGMKEEFQGRGSGKVREFALYGETTGETDEYGLPVRYDWASDYRGKALVVYGHTPQAEVLKVNNTINIDTGCVFGGKLTAYRYPEREIVDVKALKTYYEPAKPFLPKEDMAERFEARTDNDILDINDVLGKKIITTRLMSSITIHEENSIAALEVMSRFAADPHWLIYLPPTMSPCETSKKEGMLEHPIEAFEYFRTRGVGKVVCEQKHMGSRAVVIVCKDSQVAEKRFGVLDGTAGICYTRTGRHFFDDMQLEAELIDRVRKVLDKSGFWGDFNTDWVCLDCELMPWSAKAQKLLEEQYSAVGISGRVVLDEAVKLLKQASLNKTVSFDVSRQTSGKNADINELLQRFTERSEMMQKYVEAYRKYCWPVNSIDDLKLAPFHILATEGKVHSDKNHIWHMDTIAKYCTQDDSLIMATNHILVDVTDAESVDKGIKWWEDLTASGGEGMVVKPYDFIVKNGRELLQPAVKCRGREYLRIIYGPEYTMDENIERLRNRAVGKKRSLALREFSLGMEALERFVRNEPLYRVHECVFGVLALESEPVDPRL
Protein: Nucleosome assembly protein 1;3 (AtNAP1;3) (Nucleosome/chromatin assembly factor group A3) (Q94K07)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May modulate chromatin structure by regulation of nucleosome assembly/disassembly (By similarity). May function in nucleotide excision repair (NER). Involved in somatic homologous recombination. Could be involved in response to abscisic acid (ABA) and to salt stress.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19228338}. Note=Predominantly located in cytoplasm.
Interaction partners:
- Small ribosomal subunit protein eS6y
- Protein NAP1
- Histone H2B.6
- Large ribosomal subunit protein eL39z/eL39x
- Large ribosomal subunit protein eL39y
- ARM repeat superfamily protein
- Histone chaperone ASF1B
- Transcription factor GTE2
- Nodulin-related protein 1
- Telomerase reverse transcriptase
Sequence:
MSNDKDSFNVSDLTSALKDEDRAGLVNALKNKLQNLAGQHSDVLENLTPKIRRRVEVLREIQGKHDEIETKFREERAALEAKYQKLYQPLYNKRYEIVNGATEVEGAPEDAKMDQGDEKTAEEKGVPSFWLTALKNNDVISEEITERDEGALIYLKDIKWCKIEEPKGFKLEFFFDQNPYFKNTLLTKAYHMIDEDEPLLEKAIGTEIDWYPGKCLTQKILKKKPKKGAKNAKPITKTEDCESFFNFFNPPQVPDDDEDIDEERAEELQNLMEQDYDIGSTIREKIIPHAVSWFTGEAIEGEEFEIDNDDEDDIDEDEDEDEEDEDEDEEEDDEDEEEEVSKTKKKPSVLHKKGGRPQVTDDQQGERPPECKQQ
Protein: Uncharacterized protein At5g64816 (Q8L8Q8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 187-kDa microtubule-associated protein AIR9
- AT5g04550/T32M21_140)
Sequence:
MVEVWWSLIGAAVPALIAGQAWRIKKRHGEEERIKSARGREKSSDEIFVCERVCTSKRMLKKVGAFSKDPIPDTCVTVCGVSELDACSDACARTVCVNQHQVANWNDICLRRCQSECLKLSSSSSSSRYS
Protein: Monocarboxylate transporter 2 (Solute carrier family 16 member 7) (F8W0N3)
Organism: Homo sapiens (Human)
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKE
Protein: Histone H2A (B4UMZ4)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003767}.
Interaction partners:
- Helicase SWR1
- Histone H4
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome F complete sequence
- Candida glabrata strain CBS138 chromosome G complete sequence
- Candida glabrata strain CBS138 chromosome L complete sequence
- Histone H2A.Z-specific chaperone CHZ1
- RuvB-like helicase 1
- Histone H3
- Histone H3-like centromeric protein CSE4
Sequence:
MSGKMHGGKGKSGAKDGMRAQSSSARAGLQFPVGRIKRYLKRSASGKARVGSKAAIYLTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDDELDSLIRATIASGGVLPHINKALLLKVEMGKKNRN
Protein: Rab3 GTPase-activating protein catalytic subunit (Q9VQ26)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of Rab3-GAP and Rab3GAP1, which has both GTPase-activating protein (GAP) activity towards Rab3, and guanine nucleotide exchange factor (GEF) activity towards Rab18 (Probable). As part of the Rab3GAP complex, required for the rapid induction and sustained expression of synaptic homeostasis at the neuromuscular junction (NMJ) (Probable). Also participates in the regulation of autophagy in tissues such as larval fat cells and adult muscles (Probable). The Rab3GAP complex, acts as a GAP for Rab3 by converting active Rab3-GTP to the inactive form Rab3-GDP (By similarity). At the neuromuscular junction (NMJ), forms a presynaptic signaling mechanism with Rab3 that regulates progression of synaptic homeostasis at a late stage of vesicle release (Probable). Within this mechanism Rab3-GTP acts, directly or indirectly, to inhibit the progression of synaptic homeostasis, and Rab3-GAP functions to inactivate this action of Rab3-GTP (Probable). The Rab3GAP complex, acts as a GEF for Rab18 by promoting the conversion of inactive Rab18-GDP to the active form Rab18-GTP (By similarity). Regulates autophagy as part of a Rab3GAP-Rab18 module. Once Rab18 is activated by the GEF Rab3GAP complex, the Rab3GAP-Rab18 module localizes to autophagosomes, and regulates autolysosome formation and maturation together with the Rab18 interacting effector, the PI3K/Vps34 Complex I.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Rab3 GTPase-activating protein non-catalytic subunit
- GH11193p
- LP24076p
Sequence:
MAEEIDDNEFYRENFSADSDWEVFNAQLGEILQKWDVSSDSETRNLKSEEIFSCNWKVEREKLDMLRNGIEVEYHQAILEDEELVRAEAKEITCLQRTSCHHDLMSTGNSFGPPIRSSQELHILARIYGLRRFIVLHPVNPTLNYMRSTSEFNFFLSAVAVVSAEVQSLVPIFVQIYDPKWNYYTGVALAPALRTNFRLIGLEKAPPECRFLMGLLTLFREKVPTSYTQAAMISVCTTYALDTMRIRMPMYVPFDHGLSSEDIVVDGEVSHLEVQQFCALPHGYKPESRTEIYLVYTWPELSEHVAFDSEQRSDFVPAKAPLGKIYLSVEASSYLSCCLRDYQSVAEVTRSLESFVGRNFSGTSSGAEAASNPLDRITEHKLTKRRERSFELPSQAGLTKRLPGPMTESELSELLAYLFPDMHPEMALFPYAKKNFTDKFDPMRIKSAVPDSLVCRLSCLLATCHAHLGSVEGMAQVWAAFTRQLRLLWDNSLMVPGISAGFPDTRTCLLHQKLQMLNVCVERRVQREANSKRKSEGMVGKASSEEEEDEDDDEGEFFDCDDLTAGAGSPTKAVLSLKPEGRLRRLNNERLLEEPDEYLYIPDTQEPVPKTEDQLQDDAEVMLKLGPGSGLTTQMMCTSLLSDMEAFKAANPRGIMEDFIRWYSPKDWEEVTDELGQVKHQLSIRMTTEGNTWQKVWEQAQAVPVSRQKRLFDDTNEALKVLHYLETRKMHEIYNLTVIPLLHSAILKLADILSNAELEDLFSSQIEKLLSDLCRLSRSHSDELPSIKPLLDDLAELERRFYQFKCFERLSGYPKRSSLQQVKLQFEEILRNDNCCTIVNRRLTAAGDGTLYDILIPKLEEDMADRLISKDYIIRLDGDTKTTEKGLYLGPQFMRAIVTGEKLRLCGAFTESTAFV
Protein: Xyloglucan endotransglucosylase protein 8 (XET protein 8) (EC 2.4.1.207) (DkXTH8) (Xyloglucan endotransglucosylase/hydrolase protein 8) (XTH protein 8) (A0A067YMX8)
Organism: Diospyros kaki (Kaki persimmon) (Diospyros chinensis)
Function: Catalyzes xyloglucan endotransglycosylation (XET). Cleaves and religates xyloglucan polymers. Does not catalyze xyloglucan endohydrolysis (XEH). Overexpression in Arabidopsis transgenic plants causes accelerated dark-induced leaf senescence and higher lipid peroxidation of the leaf cells. Overexpression in transgenic tomato plants promotes fruit ripening and softening. Probably involved in cell wall restructuring during postharvest fruit softening.
Subcellular location: Secreted, cell wall {ECO:0000255|RuleBase:RU361120, ECO:0000269|PubMed:27966647}. Secreted, extracellular space, apoplast {ECO:0000255|RuleBase:RU361120}.
Interaction partners:
Sequence:
MAASPYSIFAVQLLLLASWMLSSSSSNFNQDFNIAWGGGRARILNNGELVTLSLDKASGSGFRSKNLYLFGKIDMQLKLVPGNSAGTVTTYYLSSEGSVRDEIDFEFLGNLTGEPYTLHTNVYSHGKGEREQQFRLWFDPAADFHTYSILWNSKTIVFYVDQTPVREFKNMESIGVPYLRQPMRLFSSIWNADEWATRGGLIKTDWTQAPFTTSYRNFRADNACVWAAKASSCGLAAGGNAWLSVELDAKSRGRLRWVRRNQMIYDYCVDGKRFPRGVPPECKLNLHI
Protein: T cell leukemia homeobox 2 (T-cell leukemia homeobox protein 2) (Tlx3a protein) (A1A5U3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- DEAQ box RNA-dependent ATPase 1.
- Lipid droplet-regulating VLDL assembly factor AUP1
Sequence:
MEHTGIEEVNQTHQQHETISFGIDQILNGSDQSSSCMLPSRTGDPDYALTPNVYNGYNSMYPACSMAAGLAGSYNVNMNMNVSMNMNVNVNSGNAGGVIRVPAHRPMPPAPHQPTAGHPPSIAAGIPTMPTVPSMGSPHSFTFPWMESSRRFAKDRLTAALSPFSVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERATLAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMLQLQQEAFQKTLSQPLQQDPLCLHNSSLYALQNLQPWAEDNKLPI
Protein: GH07093p (Q8MRP9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSLRRGGLMSYNQRRIARWYFGGLASSMAAMVTHPIDLIKVLIQTQAEKLSVFQTTRKIVKEQGPLAMYNGISASMLRQYTYTLARFGIYSVGSGAMDTSTMAGKTCLAAIAGGIGGFVGAPADLINVRLQNDVKLPPEKRRNYKHAIDGLVRITREDDGKISSMAPR
Protein: Putative pentatricopeptide repeat-containing protein At3g16890, mitochondrial (Protein PENTATRICOPEPTIDE REPEAT 40) (Q9LSQ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the ubiquinol-cytochrome c oxidoreductase activity of mitochondrial complex III.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:18305213}.
Interaction partners:
- Transmembrane 9 superfamily member 7
- Transmembrane 9 superfamily member 6
- NADH dehydrogenase subunit 2.
- NADH-ubiquinone oxidoreductase chain 2
- NADH-ubiquinone oxidoreductase chain 4
- Cytochrome b-c1 complex subunit 8-1, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4
- At4g39040
Sequence:
MRGFASSASRIATAAAASKSLNASTSVNPKLSKTLNSSGKPTNPLNQRYISQVIERKDWFLILNQEFTTHRIGLNTRFVISVLQNQDNPLHSLRFYLWVSNFDPVYAKDQSLKSVLGNALFRKGPLLLSMELLKEIRDSGYRISDELMCVLIGSWGRLGLAKYCNDVFAQISFLGMKPSTRLYNAVIDALVKSNSLDLAYLKFQQMRSDGCKPDRFTYNILIHGVCKKGVVDEAIRLVKQMEQEGNRPNVFTYTILIDGFLIAGRVDEALKQLEMMRVRKLNPNEATIRTFVHGIFRCLPPCKAFEVLVGFMEKDSNLQRVGYDAVLYCLSNNSMAKETGQFLRKIGERGYIPDSSTFNAAMSCLLKGHDLVETCRIFDGFVSRGVKPGFNGYLVLVQALLNAQRFSEGDRYLKQMGVDGLLSSVYSYNAVIDCLCKARRIENAAMFLTEMQDRGISPNLVTFNTFLSGYSVRGDVKKVHGVLEKLLVHGFKPDVITFSLIINCLCRAKEIKDAFDCFKEMLEWGIEPNEITYNILIRSCCSTGDTDRSVKLFAKMKENGLSPDLYAYNATIQSFCKMRKVKKAEELLKTMLRIGLKPDNFTYSTLIKALSESGRESEAREMFSSIERHGCVPDSYTKRLVEELDLRKSGLSRETVSAS
Protein: CD40 ligand (B9ENV6)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 5-like
- Tumor necrosis factor receptor superfamily member 5
- Tumor necrosis factor receptor superfamily member 5-like
- Tumor necrosis factor ligand superfamily member 13B-like
- Tenascin-like isoform X1
- Tenascin isoform X1
- Tenascin-like isoform X1
- Tenascin-like
- Tumor necrosis factor ligand superfamily member 13B
- Tenascin-like isoform X1
Sequence:
MINMYQTNLPPPPIPPRLGSVKSAPGPGHNKPLLGFLIGMIVLQMLLLLGGFAYLYHKENKYDKDFEHKYLDDMIVLRRLGECEKDSQSVLDCEKLVEKYKNIMEKVSQVEGKAVKLTGGVPTYGAMARMIVKQPVVGALPSSNYLEWNIGHSVLRNVQYFKSSWLKVLQPGDYDIYSQVAFSKWHPKAPLASRVKLRKGETGEEKNLMTAYCSLGDQNRTDVCTAFQGGVFSLEPKDQISVWVTDPSLVNYEEGTTTFGLYKL
Protein: Coronin-A (Coronin) (p55) (P27133)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Required for normal motility. Participates in cytokinesis.
Subcellular location: Cell surface. Note=On crown-like cell surface projections.
Interaction partners:
- dihydrofolate reductase
- Putative folylpolyglutamate synthase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
- GTP cyclohydrolase 1
- Molybdenum cofactor biosynthesis protein 1
- Actin-related protein 2
- Phosphomannomutase 1
- Phosphomannomutase 2
- Folic acid synthesis protein FOL1
- AB hydrolase-1 domain-containing protein
Sequence:
MSKVVRSSKYRHVFAAQPKKEECYQNLKVTKSAWDSNYVAANTRYFGVIWDAAGGGSFAVIPHEASGKTTSVPLFNGHKSAVLDIAFHPFNENLVGSVSEDCNICIWGIPEGGLTDSISTPLQTLSGHKRKVGTISFNPVADNVAVTSSGDFLVKTWDVEQGKNLTTVEGHSDMITSCEWNHNGSQIVTTCKDKKARVFDPRTNSIVNEVVCHQGVKNSRAIFAKDKVITVGFSKTSERELHIYDPRAFTTPLSAQVVDSASGLLMPFYDADNSILYLAGKGDGNIRYYELVDESPYIHFLSEFKSATPQRGLCFLPKRCLNTSECEIARGLKVTPFTVEPISFRVPRKSDIFQDDIYPDTYAGEPSLTAEQWVSGTNAEPKTVSLAGGFVKKASAVEFKPVVQVQEGPKNEKELREEYEKLKIRVAYLESEIVKKDAKIKELTN
Protein: Myosin IF heavy chain (P54695)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.
Interaction partners:
Sequence:
MEPLPLENEDNQLNSNKSTTVSSKNFSNIFHNNIHNKDVVGLTDMCFLENVEENELMNNLQNRFNKDHIYTYIGEQVISVNPFSNKANIYTEQVLKSYQNMYMYEVSPHIYALAQDTYKKLLLSKESQCVIITGESGSGKTEASKIFLNYISKVCSGNLENIQGIMRLIIESNIVLESFGNAKTLRNDNSSRFGKFIEIEFDGKGSPISGKISQFLLEKSRVHSRAIGERSFHVFYQFLTDKRITSKLGLSNDPTQYKYLKDSMCFSISSINDSKDFQKVLESLKQLAWTEQEMESIWRVLGAILLIGNIEFSNDVEKSNVDAVYISTPETLKKVSQLLQCSEDSLEKSLISRSLTLGAGKRQSSIKVLLNQTQAKETRDAFSKVLYDRLFTSIIDKINSTISSKSNNGSNYIIESTIGILDIYGFEIFENNSFEQFIINYSNEKLQQLFINLVLRQEQEEYLKEGIEWKTIDNYFDNTPIIDLIEGQPVGLLKLLEEACLIGQSTPELLIQKFNQFFSKNKHFESFETSNNLSIESQSFTLKHYASPVTYNLDSFIYKNKDPLYQDLIFTMESSKDKFILSLFNKDFQKNSLGVKKIPITAATQFKNAINDLIGKLNTCQPHYIRCIKSNEDKRSNHFDYEAVRHQVRYLNMLETIRVRKAGYCHKQHYTRFLGRYKMISKETWPFWNGTPKDGVMAIVRAASAIQNSTSECQFGKKKLFIKSASTLFHFEELRQKILPSIVITIQRVWRGYKVRKWYKQELQRLREEKEEIQKQIKRKNSANLIQTYYLRYKVLTYIKKLKPWSVGPHYNKGHIMPTLWLRRTPIDSLMQSIHIIWWAKVKVTSLSMEARSLVRQKILALDLFGMGYSRKKEWDCRRKFQADYLSDDSNPKKSQFSESVQAMFQKGGDKEILFADNVIKINKRGKSQLRSLIITDQHIYKYDTKKYTQKKVGLKLHSIVALSTSNKKDTFLAIHFKQPIRDLYIDLGCDFVEKVSEVCTNLVQQVYKLTGTTIPLVFRDPLTFNNSRDSRNNGTDFVVSFSQYPKGKEQRQSTFVKGKGNTAIVYYNLD
Protein: Decorin (Bone proteoglycan II) (PG-S2) (PG40) (P07585)
Organism: Homo sapiens (Human)
Function: May affect the rate of fibrils formation.
Subcellular location: Secreted, extracellular space, extracellular matrix. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}.
Interaction partners:
- Epidermal growth factor receptor
- Transforming growth factor beta-1 proprotein
- Fibronectin
- Elastin
- Y-box-binding protein 3
- Toll-like receptor 2
- Biglycan
- Y-box-binding protein 1
- Insulin-like growth factor 1
- Toll-like receptor 4
Sequence:
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
Protein: Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A) (Q3US41)
Organism: Mus musculus (Mouse)
Function: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Grainyhead-like protein 2 homolog
- Protein enabled homolog
Sequence:
MTASPDYLVVLFGITAGATGAKLGSDEKELILLLWKVVDLANKKVGQLHEVLVRPDQLELTEDCKEETKIDAENLSSAPQLDQALRQFNQSVSNELNIGVGTSFCLCTDGQLHIRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVAAMTESLNFEKSDSVSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCKMELIDDSTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKELLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFSTDIRTHGVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQKYHKKTMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPTAVIPTEAAIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANLSSVPPQPGTVVRMQGLAYNTGVKEILNFFQGYQYATEDGLVHTNDQARTLPKEWVCI