wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99) (Q9H8W5)
Organism: Homo sapiens (Human)
Function: May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15351693, ECO:0000269|PubMed:36681779}. Nucleus {ECO:0000269|PubMed:15351693}.
Interaction partners:
- SH3 and cysteine-rich domain-containing protein
- Sorbin and SH3 domain-containing protein 1
- F-BAR and double SH3 domains protein 2
- Spartin
- Killer cell immunoglobulin-like receptor 2DL1
- T-cell receptor-associated transmembrane adapter 1
- Killer cell immunoglobulin-like receptor 2DL4
- E3 ubiquitin-protein ligase TRIM41
- Killer cell immunoglobulin-like receptor 3DL1
- Killer cell immunoglobulin-like receptor 3DL3
Sequence:
MSENRKPLLGFVSKLTSGTALGNSGKTHCPLCLGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGDSDTSSEGSIFQELKPRSLQSQIGILCPVCDAQVDLPMGGVKALTIDHLAVNDVMLESLRGEGQGLVCDLCNDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSRIGKPILCPVHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWELLKGTQPHVEALEEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQLEDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNKVQYSTRPGVNDKIRFCPQEKAGQCRGYEIYGTINTKEVDPAKCVLQGEDLHRAREKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMVQDNKDGTYYISYTPKEPGVYTVWVCIKEQHVQGSPFTVMVRRKHRPHSGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGHPHWSCCGKFNEKSECTWTGGQSAPRSLLRTVAL
Protein: Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (A0A8I6A6L8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000933}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQEVFRRVSIADPAALGFIISPWSLLLLPSGSVSFTDENVCSQDLRAFTAPEVLQSHSLTSLSDVEKVHIYSLGMTLYWGADHEVPQSQPIKLGDHLNSILLGMCEDVLYARVSVRTVLDACSAHIRNSNCAPSFSYVKQLVKLVLGNISGTDPLSHSSEEKPDRSQAIRDRLRGKGLPIGRSSTSDALDTHKAPLSQQTFLNKGLSKSMGFLSVRDTQEEEDYSKEIPSDNNSRHEDSEPFSSPYQFKTSSPHIDVLSKKKTWASSMDLLCAADRDLSGEIGRYQHCDPETGTGRTSITSRKKEGRYSDGSIALDVFGPQKAEPVIHSRELPASSAVSSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHSDLFSTSSESPSIISSDSDFRQVRKSEASKRFESSSGLPGVDDTVQSRPSRQYETSLEGSLINQEMMLRRQEEEMMQLQARMALRQSRLSLYPGDTIKTSMLDISRDPLREMALETAMTQRKLRNFFGPEFVKTTVEPFASLDLPRSILLQTKKGKSEEQRKKVNIMLLSGQRLELTCDTKTVCRDVFDMVVAHIGLVEHHLFALATLKENEYFFVDPDLKLTKVAPEGWKEEPKRKGKAAVDFTLFFRIKFFMDDVSLIQHSLTCHQYYLQLRKDLLEERIHCDDEASLLLASLALQAEYGDYQPEVHGLSYFRLEHYLPARVMEKLDMSYIKEELPKLHNTYAGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRALVLRFPWRETKKISFSKKKITLQNTSDGIKHAFQTDSSKACQYLLQLCSSQHKFQLQMRARQSNQDAQDLDSLHKRWSTVSSPEREITLVNLKKDLKHGLGFQIVGGGKMGRLDLGVFISAVTPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAVDILQNAPEDVTLVISQPKEKPTKVPSTPVHFANGMKNYTKKPSSMQDSAMDPSEDQPWPRGPLRHVPESPFGLSSGLREGSLSSQDSRTESASLSQSHVNGFFTSHLGDRGWQEPQHSSPSPPVTSKITEKTFSDSYRSPARRQGTCDVTELPGCADSDIDDPTYSSSQDRQAPKQEPSSPLKASDKMSFAAFPGPSPEPGDAFEVELAKTDGSLGISVTGGVNTSVRHGGIYVKAVIPNGAAETDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSRERDPASPRCPTPDQDAQSQAPEKMEKQTAHVKDYSFVTEDNTFEVKLFKNSSGLGFSFSREDNLTPELINGSIVRVKKLFPGQPAAESGKINVGDVILKVNGAPLKGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEVNTALLTPLHSPAHAFLNSRKEHSQPSPLSVEQCASSDENGLSGQSKRQCKPPSRRESYSDHSDSGEEESVRAAAKMPNVIPLSAFAPEALRSQGEPASTMFYLPRKIPGKPESESSRLPHPLDVSPGQIRQPPAECAPSDSPGKHLTHLASQLHKEENMTALKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGCYVHDVIQDPAKGDGRLRPGDRLVKVNDADVTNMTHTDAVNLLRAAPKTVRLVIGRILELPRMPVFPHLLPDITVTCHGEELGFSLSGGRGSPHGVVYISDINPRSAAAVDCSLQLLDIIHYVNGVSTHGMTLEEANRALDLSLPSVVLKVTRDGCPVVPCSTRSAISALRPLEANGLSSMEPYGQPALTPKKSFSKVNGDGASGAMCPGGKGLSSPRKKSADLMEARESDSRDDDVYDDPQEAEVIQSLLDVVDEEAQNLLNQTKASRRACSPDPLRTNGEASEDGEDTDCDGSPLPEDVPESVNGGGGKACFASLIQASQEEKPVKEEATQESRESTTETTDREDSSKDPLFLTNEELAALPVVRVPPSGKYTGTQLQATIRTLQGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDTTRVPLGDEGGYINASFIRIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSILGTTTMANERLRLALLRMQQLKGFVVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSHPEDLLTFISYMRHIRRSGPVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEGQYVFCYQVVLYVLTHLQAEEQKAQPGLPQ
Protein: Peptide Im-4 (Im4) (C0HL59)
Organism: Isometrus maculatus (Lesser brown scorpion) (Scorpio maculatus)
Function: Probably forms pores in target membranes. Has antibacterial activity against Gram-positive bacteria S.aureus NBRC 13276 (MIC=5-10 uM) and B.subtilis NBRC 3009 (MIC=2.5-5 uM) but not against Gram-negative bacterium E.coli NBRC 3972.
Subcellular location: Secreted {ECO:0000269|PubMed:28941793}. Target cell membrane {ECO:0000305|PubMed:28941793}.
Interaction partners:
Sequence:
MKFQYLLAIFMIVLVVTDHCQAFIGMIPGLIGGLISAIKGRRRRQLEARYEPQQRNFRKREIDFEKLFANMPDY
Protein: Transmembrane protein (Q57VR0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGWWRRGSSSSNGMQRVVETHFWSLTRYRIGRRFLGLDYADNVIFFPAYRSKRRGGWAAVTLGVTSSSNYFTNDTSAVNVLEDGYPLHWRANSRLKEFVAEEKKLWQARVKEEVAQLAAEKVSASRTGDPNGGAAKEPGDLMGDINCEHRFRDTLAIKCTSPGFAQRHLRLSRLWTSLYKFLYFYLWGIGISLVVQAYLLFRSWLNPPARQGLKNIEAHVLHIPKLIFGFCVSCVVWAAHHLQPVVSPVLEALEGVFPQVNWSAASPEALATKAQQLAGHDVSGGKHGSGQLDQLNVKKTTETMAGNWAVFFSGNFTSIMQGLVFLLAVLLFLL
Protein: tRNA nucleotidyltransferase, putative (EC 2.7.7.72) (Q38E99)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTARTVSVIRVNPELSKHIETATVCVYDTPIEFCALRHDEYTRSDSRIPVVRPATTVEDALRRDYTVNALFYNLHTKEVEDYTTGLEDLDRRILRCPLDPKETLTDDPLRLLRGVRFVGQLGELGFVLDESIFRCVDKELLKKVTLKVSRERVGKELVKMLSGPFAEKCIETLHELNLLREVILVELHLKSSKKGCVTAEVERTEHLAYNGEAGSTGLECLLSLNRTLVPLFSRSGSKVQLSPDSPDKLIAMIFISCLGFYRGVSQSQIEDRLYALCVNGLKLPVSSYNTVRRMIECYNTLKREGLNVCEISDGEVTTAAKLAIFKGLNDLNDKKTIPSAFNIVFAAFILIEHRCDLLAGGDVEGSGCVVDRLLLALEQVPGLLDAFSRPLPLRGNELAKLVPLEPPQIGPALLALRQYLMLHPQASKDDMIHWLRQGGSS
Protein: C3H1-type domain-containing protein (Q57XW7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nuclear cap binding complex subunit CBP110
- Nuclear cap binding complex subunit CBP30
- Nuclear cap-binding protein subunit 2
Sequence:
MPPRRSFVFITNIPDYLLQPLAVGNNNHHNKLRASRDPRYERLRSFLSTHTSGVMHVMHLETRGYALALYASEEEALAACKTTITPKYRQCEYPPMVLRILERPRPAPLQSVYTPTVTIEGETILKEELANTRGLELVYRGRAIARWCPNTLSQQDCPFGASCNWIHKCAYQQTVRKRPRLDPVSQQQQQKQPMSSEELTRLRHVTHNTKCGEEQLVPTDMKFDFSVYVPVAYKEAVALVDSEGTGGSNRLVDDVIKRVEAACSAYSGPYFVKFAFCGGAPWDWSLHNTSLGLSALRKRAPFPTNGAPTPLERDIFTQQLLYHMNQMNRFDTIALAVHALAKSPKVRRALQRELEYDQSLTSCNDKGDKDAVSLHLCVRPWLFLPTVGVEATVFLEGGGEVLRGIVQRKGAVRLMISHALLRQQEEKQGMDFSRFAVLGSGQDLEAESYLESEIQRMSLLVKRSAQRLQQYIRQQRDRFPPGAAWCVHIAVSPPPLVPFRPQQYGSGVEQQKGECKQEESEERVTSKCVVLSLQEYQPAYEEHVALHGELRAGEVMWNTRKHGYVALIPREMLERLRLESQVEEKE
Protein: Protein IQ-DOMAIN 13 (AtIQD13) (Q9M199)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). Regulates the formation of oval xylem secondary cell-wall deposition pits through microtubule-dependent lateral inhibition of Rho GTPase domains, thus confining the area of active ROP domains within the lattice of the cortical microtubules. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:28115582, ECO:0000269|PubMed:28803875}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:28115582, ECO:0000269|PubMed:28803875}. Note=Recruits calmodulin (CaM2) to microtubules (PubMed:28115582). Associates with cortical microtubules and the plasma membrane to laterally restrict the localization of ROP GTPase domains (PubMed:28803875). {ECO:0000269|PubMed:28115582, ECO:0000269|PubMed:28803875}.
Interaction partners:
- Rac-like GTP-binding protein ARAC10
- Kinesin-like protein KIN-13A
- Interactor of constitutive active ROPs 5
- Rho GTPase-activating protein 3
- At5g19870)
- Transmembrane E3 ubiquitin-protein ligase FLY2
- Rop guanine nucleotide exchange factor 4
- F-box protein PP2-A12
- Filament-like plant protein 3
Sequence:
MGKKGSWFSAIKRVFTPHSKEKQLSNNNQEPEIKSENKEKKKKGFGKKLRNGETNSFLPIFRQPSSIEKILSEAEREHNLVFRPPTPTDRANSSSTSVASPLVRPASPKVPSQRYVSSPKPISPRVAYPQVHYPKPPSPKPPSPRAVSPRIVQRREFVHRPEPSLLVKNAYAIKIQAAFRGYMARRSFRALKGLVRLQGVVRGHSVKRQTMNAMKYMQLLVRVQTQVQSRRIQMLENRARNDKDDTKLVSSRMSDDWDDSVLTKEEKDVRLHRKIDAMIKRERSMAYAYSHQLWKNSPKSAQDIRTSGFPLWWNWVDRQKNQNQPFRLTPTRPSLSPQPQSSNQNHFRLNNSFDTSTPNSSKSTFVTPSRPIHTPQPYSSSVSRYSRGGGRATQDSPFKDDDSLTSCPPFSAPSYMAPTVSAKAKLRANSNPKERMDRTPVSTNEKRRSSFPLGSFKWNKGSLFMSNNSNNKGPGSSSSGAVVLEKHKTLKSVGNLSIDSTVSMPATIGRRAFNRFA
Protein: Protein transport protein SEC23 (Q9NFN9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|RuleBase:RU365030}; Peripheral membrane protein {ECO:0000256|RuleBase:RU365030}; Cytoplasmic side {ECO:0000256|RuleBase:RU365030}. Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU365030}; Peripheral membrane protein {ECO:0000256|RuleBase:RU365030}; Cytoplasmic side {ECO:0000256|RuleBase:RU365030}.
Interaction partners:
Sequence:
MTTYEEFIQQNEDRDGVRLTWNVWPSSRIEASRLVVPLACLYQPLKERPDLPPIQYEPVLCTRSNCRAILNPLCQVDYRAKLWVCNFCFQRNQFPPQYAAISEQHQPAELIPGFSTIEYTITRAPTMPPVFIFLVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVFRGTKDLTAKQVQDMLGIGRRAAPGPQQQQHLPGQPAGAAAPVRFLQPIGQCDAALGDLLSELQRDPWPVPQGKRYLRSTGAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPIRSHHDIHKDNVRFMKKAIKHYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMGDSFNSSLFKQTFQRVFARDGRNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVEIGMGNTVQWKLCTLNPSSTVAYFFEVVNQHAAPIPQGGRGCIQFITQYQHPSGQRRIRVTTLARSWADATSNVHHISAGFDQEAAAVLMARMVVYRAETDEGPDILRWVDRQLIRLCQKFGEYSKDDPNSFRLSQNFSLFPQFMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFNGPPEPVLLDTASIQADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYENFKQLLQAPVDDAQEILQTRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAYGQDGGAPVLTDDVSLQLFMEHLKKLAVSTTT
Protein: Small ribosomal subunit protein uS17 (40S ribosomal protein S11) (P62282)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62280}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62280}.
Interaction partners:
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein uS9
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein eS1
Sequence:
MADIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVTKAAGTKKQFQKF
Protein: Coatomer subunit alpha (Q6DRK5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR003354}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR003354}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR003354}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004347}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004347}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004347}.
Interaction partners:
Sequence:
MLTKFETKSARVKGLSFHPKRPWILASLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRIWNWQSRTCVCVLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDISGLRKKNLSPGAVDTEVRGISGVDLFGASDAVVKHVLEGHDRGVNWAAFHPSMPLIVSGADDRQVKIWRMNESKAWELDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLGAHPNLNLFAAGHDSGMLVFKLERERPAYAVYGNMLYYVKDRFLRQLDFNSSKDTAVMQLRSGSKFPVFSMSYNPAENAVLLCTRATNLENSTYDLYSIPRESDSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEIVKKVQVPSCEEIFYAGTGSLLLRDAEGVTLFDVQQKRSLATVKIAKVKYVVWSSDANHVALLAKHAIMICNKKLESLCNIHENIRVKSGAWAENEVFIYTTSNHIKYALTSGDHGIIRTLDLPIYVTRVRGNSVYCLDRECRPRVLNIDPTEYRFKLALVNRKYEEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEVALEAAKALDERSCWERLGEAALLQGHHQVVEMCYQRTKNFDKLTFLYLITGNLTKLRKMMKIAEIRKDMSGHYQGALYLGDVSERVRILKNCGQKSLAYLTAATHGMDEEAEALKETFDLEKEMVPEVDPNAQLLQPPPPINPLDTNWPLLTVSKGFFEGAIAAKGRAGQMVADLDMDAPGGEGWGEDAELHLDEDGFMDAQEGLGDEGAIGKDDGGGWDVEEDLDLPPELDVPSVGGGGAEGEGFFVPPTKGTSPTQMWCNNSQLSVDHILAGSFETAMRLLHDQVGVVQFGPYKQLFMQTLSRGRTCYLGLPSLPCLHSFPLRNWKDSGPKGGLPAVGLRLADLISRLQQCYQLTTSGRFEDAVERFRAILLSVPLLVVDNKQEIAEAQQLITICKEYIIGLTMETERKKLPKDSLDEQKRICEMAAYFTHCSLQPVHMVLVLRTALNLFFKLRNFKTAAGFARRLLELGPKPEVAQQTRKILAACEKSLTDAHQLNYDPHNPFDICAASYTPLYRGRPVEKCPLSGACYCPKYKGEVCRVTQVTEIGKDVIGLRVSPLQFR
Protein: Potassium voltage-gated channel unc-103 (Ether-a-go-go-related gene potassium channel homolog) (ERG homolog) (Eag-related protein homolog) (Ether-a-go-go-related protein homolog) (Uncoordinated protein 103) (G5EFJ9)
Organism: Caenorhabditis elegans
Function: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly (By similarity). Regulates the movements of the male's copulatory spicules before and during male mating behavior.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q12809}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Voltage-dependent L-type calcium channel subunit alpha
- Calcium/calmodulin-dependent protein kinase type II
Sequence:
MKTAVFGRDSGEPGSPCGAPPSLTFTPPATLVPPTHHHSRSTNRGGVSGTGGGGSGGLQGAPGAGGPRASHSSRRTSRLHNNVSALGVLSLGADVLPEYKLQPTRIHHCTIVHYSPFKAVWDWIILLLVIYTAVFTPYVAAFLLRELQDTAKKSRFTEPLEIVDLIVDIMFIVDIIINFRTTYVNENDEACQVVSDPGKIATHYFKGWFIIDMVAAVPFDLLLVSTNSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLLLLMATFALIAHWLACIWYAIGSAELSHKEYTWLHQLSKQLAQPYTSTNGTIPTGGPTLKSRYVTSLYFTLSTITSIGFGNVSATTDSEKIFTIIMMILGSLMYASVFGNVSAIIQRLYSGTARYHTEMSRLREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNLVLKGFPDCLQADICLHLNRNLLSGCAAFAGSTPGCLRALSMRFRTTHSPPGDTLVHRGDILTGLYFIARGSVEILNDDNTVMGILGKDDIFGENPLLYDEVGKSSCNVRALTYCDLHKILRDDLLDVLDMYPEFAETFCKNLTITYNLRDDAQSLRKKFDRHKLLRMSSSMNKDRYTTPPDGDHGNAAVRRSAESVSRCDSNPIDRRQSAGSRSSSRCSPPHAALTATRSEATPLLRRSTNHHEEDDALFDDIRAFARGNTVTMSPTVAGNSVSPTTAIHNDGIHSQQLSDRSDDYEERRANMFGRRLESIESQMERMQNKFNSDMETLIKLVKEQSIIRNNGSSNEEPNARYRPNNYISSAIRLPNGGGGGVVDEMRVSRLSSHEPPTPTQETDTIL
Protein: Protein phosphatase 2C homolog 2 (PP2C-2) (EC 3.1.3.16) (P39966)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28.
Subcellular location: Nucleus {ECO:0000269|PubMed:12477803}. Cytoplasm, cytosol {ECO:0000269|PubMed:12477803}.
Interaction partners:
- Polyamine N-acetyltransferase 1
- Serine/threonine-protein phosphatase 4 catalytic subunit
- Tyrosine-protein phosphatase 3
- Serine/threonine-protein kinase RAD53
- Mitogen-activated protein kinase HOG1
- Protein phosphatase 2C homolog 1
- Protein phosphatase 2C homolog 3
- Phosphatase DCR2
- Protein phosphatase 2C homolog 7, mitochondrial
- NAP1-binding protein 2
Sequence:
MGQILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSKSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEGTGIGCDNMSIVVVALLKEGEDVAQWSDRMKSKAHRTSVRSFADKRRRVFSYYDFSKCNDEQVFAITTKKPQDKFTRDHEAAVASVTAADNDDPMDIDDTDADTDAENLDPSSQSKSKTSGPIDLASLEALLGATGGVKTDSNGNKVTYTLPQSALAQLLQTMGHDPASSHPENDSNTDHKAGRSHLQ
Protein: Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II) (P29803)
Organism: Homo sapiens (Human)
Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Pyruvate dehydrogenase protein X component, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- L-lactate dehydrogenase C chain
- Pyruvate kinase PKM
- Pyruvate kinase PKLR
- L-lactate dehydrogenase A chain
- Pyruvate carboxylase, mitochondrial
Sequence:
MLAAFISRVLRRVAQKSARRVLVASRNSSNDATFEIKKCDLYLLEEGPPVTTVLTRAEGLKYYRMMLTVRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHGVCYTRGLSVRSILAELTGRRGGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACKYKGNDEICLTLYGDGAANQGQIAEAFNMAALWKLPCVFICENNLYGMGTSTERAAASPDYYKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQFATTDPEPHLEELGHHIYSSDSSFEVRGANPWIKFKSVS
Protein: Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (Activin receptor-like kinase 6) (ALK-6) (RPK-1) (Serine/threonine-protein kinase receptor R6) (SKR6) (Q05438)
Organism: Gallus gallus (Chicken)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcription (By similarity). Positively regulates chondrocyte differentiation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P36898}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Bone morphogenetic protein 4
- Bone morphogenetic protein 7.
- Growth/differentiation factor 5
- Bone morphogenetic protein 6.
- Bone morphogenetic protein 2
- Growth differentiation factor 6
- Mothers against decapentaplegic homolog 5
- Mothers against decapentaplegic homolog.
- TGF_BETA_2 domain-containing protein.
- BMP5
Sequence:
MPLLSSSKLSMESRKEDSEGTAPAPPQKKLSCQCHHHCPEDSVNSTCSTDGYCFTIIEEDDSGGHLVTKGCLGLEGSDFQCRDTPIPHQRRSIECCTGQDYCNKHLHPTLPPLKNRDFAEGNIHHKALLISVTVCSILLVLIIIFCYFRYKRQEARPRYSIGLEQDETYIPPGESLKDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKGMLKLAYSSVSGLCHLHTGIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKRLRPSFPNRWSSDECLRQMGKLMMECWAHNPASRLTALRVKKTLAKMSESQDIKL
Protein: PHD finger-containing protein 1 (B3H578)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSLHVKGPVCQTCGDIGFEEALVFCDSCMFESIHRYCLGITPIPFTEYITWICEDCDNSESDSDCNEVDQTVKKKKKSRNQPLVVLAEDNVLQEPLEGSKREESSCSRKPHELTCLDGNGESVLEAADSSSVPDHSSCTSKRKEVDQTANLGHILERSEKKKKKKKKKKSINHSPPVLAVEDHELQGTTNVVEPVEVSSSSPTKETMESKRQESSDSRKPHELTCLVGDSETANSSSVPEHNSCAVKKRKLSSGNKQIQLADGSSSCRVAESNMPLTLTSRNYRAQPIKIPIWRGLMSVKGGNSCTMDGIVAHVSSLACPKVHETASSLKGRLSAEILPRLEVWPKTFLKNGGPKDESVALFFFPSSESNDEKVFDSLVDKMKKNDSAMRCVLNDAELLLFTSYMLPKDSWTFNSKYYLWGVFKPRQTSRY
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Q9U3H4)
Organism: Caenorhabditis elegans
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 alpha subcomplex subunit 7
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase iron-sulfur protein 5
- NADH dehydrogenase 1 beta subcomplex subunit 4
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- Probable NADH dehydrogenase 1 beta subcomplex subunit 2
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase iron-sulfur protein 4
- Probable NADH dehydrogenase flavoprotein 2, mitochondrial
Sequence:
MWFEQFYSGVITTAFVAGACYMSYPFNKWDVGRAFRRNYCTPQRVELSKRDHRLTGNQYRIAGLDAFPEK
Protein: Lectin-domain containing receptor kinase VI.3 (LecRK-VI.3) (EC 2.7.11.1) (Lectin receptor kinase A4.2) (Q9M020)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in negative regulation of abscisic acid response in seed germination.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLVLFLLLTIPTRAQRTTTETPKTEFIFRGFSGNQSNIVTTGAATIKLDGLLRLTDRNSNVTGTSFYHKPVRLLETNTSSTNSTIRSFSTSFVFVIIPTSSSNGGFGFTFTLSPTPDRTGAESAQYLGLLNKANDGNSTNHVFAVEFDTVQGFKDGADRTGNHIGLNFNSLTSDVQEPVVYYDNEDPNRKEDFPLQSGDPIRAILDYDGPTQTLNLTVYPANLKSRPVRPLISRPVPKLSQIVQEEMYVGFTAATGRDQSSAHYVMGWSFSSGGDLLTEDTLDLLELPRPPPNTAKKRGYNSQVLALIVALSGVTVILLALLFFFVMYKKRLQQGEVLEDWEINHPHRLRYKDLYAATDGFKENRIVGTGGFGTVFRGNLSSPSSDQIAVKKITPNSMQGVREFIAEIESLGRLRHKNLVNLQGWCKQKNDLLLIYDYIPNGSLDSLLYSRPRQSGVVLSWNARFKIAKGIASGLLYLHEEWEKVVIHRDIKPSNVLIEDDMNPRLGDFGLARLYERGSQSNTTVVVGTIGYMAPELARNGKSSSASDVFAFGVLLLEIVSGRRPTDSGTFFLADWVMELHARGEILHAVDPRLGFGYDGVEARLALVVGLLCCHQRPTSRPSMRTVLRYLNGDDDVPEIDNDWGYSDSSRSDLGSNFEGYVSSDRASSSVPSFSVTRVSSSSVISGR
Protein: Uncharacterized protein (Q97Z82)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Interaction partners:
- Single-stranded DNA exonuclease
- DNA primase small subunit PriS
- DNA polymerase sliding clamp 2
- Large ribosomal subunit protein eL42
- Ribosome biogenesis protein Nop10
- Small ribosomal subunit protein eS27
- Translation initiation factor 2 subunit alpha
- GINS subunit domain-containing protein
- GTPase
Sequence:
MLDELVKKELSEEEITEIKLEEIIKYITLIKKSKTFVSSEIRKEELKFLSELAESLFELRLSKVLEGKVGKGFDEFIFDIFKILKQFYVDLLTGRYIIYNDKIYCIVQKPLIYNDHRVNEGDVLVLPMREALPLIIASYLTPYKIDIEEQL
Protein: Leukocyte immunoglobulin-like receptor subfamily B member 4 (B4) (CD85 antigen-like family member K) (Immunoglobulin-like transcript 3) (ILT-3) (Leukocyte immunoglobulin-like receptor 5) (LIR-5) (Monocyte inhibitory receptor HM18) (CD antigen CD85k) (Q8NHJ6)
Organism: Homo sapiens (Human)
Function: Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance. Receptor for FN1. Receptor for apolipoprotein APOE. Receptor for ALCAM/CD166. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production. This inhibition of monocyte activation occurs at least in part via binding to FN1. Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells. Induces up-regulation of CD86 on dendritic cells. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19833736, ECO:0000269|PubMed:9151699}; Single-pass type I membrane protein {ECO:0000269|PubMed:9151699}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment. {ECO:0000269|PubMed:9151699}.
Interaction partners:
- Tyrosine-protein phosphatase non-receptor type 6
- HLA class I histocompatibility antigen, alpha chain G
- Tyrosine-protein kinase SYK
- Probable non-functional immunoglobulin heavy variable 3-16
- Apolipoprotein E
- CD166 antigen
- T-lymphocyte activation antigen CD86
- HLA class I histocompatibility antigen, alpha chain E
- CMRF35-like molecule 6
- HLA class I histocompatibility antigen, alpha chain F
Sequence:
MIPTFTALLCLGLSLGPRTHMQAGPLPKPTLWAEPGSVISWGNSVTIWCQGTLEAREYRLDKEESPAPWDRQNPLEPKNKARFSIPSMTEDYAGRYRCYYRSPVGWSQPSDPLELVMTGAYSKPTLSALPSPLVTSGKSVTLLCQSRSPMDTFLLIKERAAHPLLHLRSEHGAQQHQAEFPMSPVTSVHGGTYRCFSSHGFSHYLLSHPSDPLELIVSGSLEDPRPSPTRSVSTAAGPEDQPLMPTGSVPHSGLRRHWEVLIGVLVVSILLLSLLLFLLLQHWRQGKHRTLAQRQADFQRPPGAAEPEPKDGGLQRRSSPAADVQGENFCAAVKNTQPEDGVEMDTRQSPHDEDPQAVTYAKVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMDTEAAASEAPQDVTYAQLHSFTLRQKATEPPPSQEGASPAEPSVYATLAIH
Protein: FAS1 domain-containing protein mug57 (Meiotically up-regulated gene 57 protein) (Q9Y801)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in sporulation.
Subcellular location: Cytoplasm. Nucleus. Membrane; Peripheral membrane protein. Note=Membrane-associated.
Interaction partners:
- Transcriptional regulatory protein sds3
- Histone deacetylase clr6
Sequence:
MMKLFCLNIFRFLYTTSFISAVLSFNQRPINMQEVREPRLFELLAETRDCNIFSELIMQFPDYVHLFQQKDQHITVLVPNDAAFQQCKVKPWAIEYKNGVAVKSTDIVHITEQQAQDNILKFVERHIITSSPIEWNNEYKTIDGTDVHVIKKEEEIYINESIHVLCRKKASNGEMWVLNATLSTPSIRE