wanglab/gogpt-training-data huggingface dataset:
Protein: Metabotropic glutamate receptor 2 (mGluR2) (P31421)
Organism: Rattus norvegicus (Rat)
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Subcellular location: Cell membrane; Multi-pass membrane protein. Synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- 5-hydroxytryptamine receptor 2A
- Metabotropic glutamate receptor 3
- Aromatase
- Metabotropic glutamate receptor 7
- Metabotropic glutamate receptor 8
- Glutamate receptor ionotropic, NMDA 2B
- Metabotropic glutamate receptor 6
Sequence:
MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
Protein: Competence protein E (Q4QNB0)
Organism: Haemophilus influenzae (strain 86-028NP)
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004442, ECO:0000256|RuleBase:RU004004}.
Interaction partners:
Sequence:
MKKYFLKCGYFLVCFCLPLIVFANPKTDNECFFIRLSQAPLAQTLEQLAFQQDVNLVMGERLEGNISLKLNNIDMPRLLKIIAKSKHLTLNKDDGVYYLNGSQSGKGQVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSSAGSITFDDRSNLLVIQDEPRFVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLTGNSFENIADNLNVNFATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYIVSNTRNDTQSVEFREAVLGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDIPVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKK
Protein: Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) (P42694)
Organism: Homo sapiens (Human)
Function: May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Histone-lysine N-methyltransferase SMYD3
- CCR4-NOT transcription complex subunit 1
- Homeobox protein Nkx-2.8
- Roquin-2
- PHD finger protein 3
- Roquin-1
Sequence:
MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESLLYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLTGESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSAPYPHHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
Protein: Mitochondrial import inner membrane translocase subunit TIM50 (Q3ZCQ8)
Organism: Homo sapiens (Human)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:15044455}; Single-pass membrane protein {ECO:0000269|PubMed:15044455}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus speckle {ECO:0000269|PubMed:16008839}. Note=Nuclear and enriched in speckles with snRNPs. {ECO:0000269|PubMed:16008839}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim17-A
- Mitochondrial import inner membrane translocase subunit Tim21
- Mitochondrial import inner membrane translocase subunit Tim23
- Mitochondrial import inner membrane translocase subunit Tim17-B
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import receptor subunit TOM40 homolog
- Mitochondrial import inner membrane translocase subunit Tim10
- Mitochondrial import receptor subunit TOM22 homolog
Sequence:
MAASAAVFSRLRSGLRLGSRGLCTRLATPPRRAPDQAAEIGSRGSTKAQGPQQQPGSEGPSYAKKVALWLAGLLGAGGTVSVVYIFGNNPVDENGAKIPDEFDNDPILVQQLRRTYKYFKDYRQMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLGSLTSRLWPRSKQP
Protein: methylmalonate-semialdehyde dehydrogenase (CoA acylating) (EC 1.2.1.27) (O53816)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable 3-hydroxyisobutyrate dehydrogenase
- Probable acyl-CoA dehydrogenase FadE9
- Acetyl-coenzyme A synthetase
- 4-aminobutyrate aminotransferase
- Aldehyde dehydrogenase
- Probable aldehyde dehydrogenase NAD dependent AldA
- Steroid 3-ketoacyl-CoA thiolase
- Phosphate acetyltransferase
- Probable fatty oxidation protein FadB
- Probable aldehyde dehydrogenase
Sequence:
MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQFYTKVKTVTSRWPSGIKDGAEFVIPTMS
Protein: Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) (Q9MYV3)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
Subcellular location: Secreted {ECO:0000250}. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin. {ECO:0000250}.
Interaction partners:
- Vascular endothelial growth factor receptor 2
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L3
- Fms related tyrosine kinase 1
- Insulin-like growth factor 1
- Matrix metalloproteinase-9
- Hepatocyte growth factor
- Matrix metallopeptidase 2.
- Pro-epidermal growth factor
Sequence:
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAGGEHKPHEVVKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEEFNITMQIMRIKPHQGQHIGEMSFLQHSKCECRPKKDRARQEKKSIRGKGKGQKRKRKKSRYKPWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Protein: Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha) (mt-Fem) (Q9Z2G0)
Organism: Mus musculus (Mouse)
Function: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation (By similarity). Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity (By similarity). Promotes ubiquitination and degradation of ANKRD37. Promotes ubiquitination and degradation of SLBP (By similarity). Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (By similarity). Also involved in glucose homeostasis in pancreatic islet. May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15601915, ECO:0000269|PubMed:21723927}. Nucleus {ECO:0000250|UniProtKB:Q9UK73}. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin. {ECO:0000250|UniProtKB:Q9UK73}.
Interaction partners:
- Cullin-2
- Folliculin-interacting protein 1
- E3 ubiquitin-protein ligase RBX1
- Amyloid protein-binding protein 2
- Elongin-B
- Ankyrin repeat domain-containing protein 37
- Kelch domain-containing protein 10
- Protein zer-1 homolog
- Kelch domain-containing protein 3
- Kelch domain-containing protein 2
Sequence:
MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIMKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELEAIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNEAVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHSAMDNYECNLYTFLYLVCISTKTQCSEEDQCRINKQIYNLIHLDPRTREGFSLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH
Protein: G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) (P32298)
Organism: Homo sapiens (Human)
Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Subcellular location: Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.
Interaction partners:
- ARF GTPase-activating protein GIT1
- ARF GTPase-activating protein GIT2
- Beta-arrestin-1
- Beta-arrestin-2
- Mu-type opioid receptor
- Rho guanine nucleotide exchange factor 6
- Rhodopsin
- Paxillin
- C-X-C chemokine receptor type 4
- S-arrestin
Sequence:
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
Protein: Uncharacterized protein (Q57X27)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVFFVRVTGKDLSGNTQNIRLLFPSKPTLYDLTCAIERYFTTAAEKEQKEEPSQETPYMLELLLLLDEYRSRWVELYSSGQLTTDCLVHAFSKQTVKALRGKKGVMSRYGSSTSGIVTSATTVTPSNAAPSAAQGNSANITQDVGLHNSTSVVHYNNAM
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q7Y236)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MMPSVNPDQSDKDSEPFVEADPTGRYGRYTELLGSGAVKKVYRAFDQEEGIEVAWNQVKLRNFSDDPAMIDRLYSEVRLLRSLTNNNIISLYSFWRDEEHNTLNFITEVCTSGNLREYRKKHRQVSMKALKKWSKQILKGLNYLHSHEPCIIHRDLNCSNVFVNGNTGQVKIGDLGLAAIVGKNHSAHSILGTPEFMAPELYDEHYTELIDIYSFGMCVLEIVTLEIPYSECDNVAKIYKKVSSGVKPQALDKVRDADMRAFIERCIAQPGERPSAAELLKDPFYDEVDDYDENV
Protein: Regulator protein (Transcriptional regulatory protein EmbR2) (O53145)
Organism: Mycobacterium tuberculosis
Interaction partners:
Sequence:
MARNELRFGILGPLEISAGFRSLPLGTPKQRAVLATLIIHRNRPVGIDSLIDAAWEQDRPEGSRATVYTYVSNLRRLVSTTGADSHSILASAPPGYRLAVADNQYDVARFISQRSAGLRAAAAGSFEQASDHLSAALAEWRGPVLDDLREFSFVTRLANSLVEDKIIAHTALAEAEIACGRADSVISELEELILEHPYHEALWRQLIAAYYVSERQSDALDAYRRLKTSLAEDLGVDPGPKVRTLYEQVLRQQALDTRVVVQAAAGDIIRALEHSPGMTDRSPRAAIRDAAGHRSPLGRLPLRIGRSKSNDMVLPDGKVSPYHAVIVNTGESFMITDLRSVNGVYVRGRRIATTATLNDGDHIRIGDHELTFEVIPHESGR
Protein: DNA-directed DNA polymerase (EC 2.7.7.7) (E7DN81)
Organism: Pneumococcus phage Dp-1 (Bacteriophage Dp-1)
Interaction partners:
Sequence:
MNLASKYRPQTFEEVVAQEYVKEILLNQLQNGAIKHGYLFCGGAGTGKTTTARIFAKDVNKGLGSPIEIDAASNNGVENVRNIIEDSRYKSMDSEFKVYIIDEVHMLSTGAFNALLKTLEEPSSGTVFILCTTDPQKIPDTILSRVQRFDFTRIDNDDIVNQLQFIIESENEEGAGYSYERDALSFIGKLANGGMRDSITRLEKVLDYSHHVDMEAVSNALGVPDYETFASLVEAIANYDGSKCLEIVNDFHYSGKDLKLVTRNFTDFLLEVCKYWLVRDISITQLPAHFESKLEQFCEAFQYPTLLWMLEEMNELAGVVKWEPNAKPIIETKLLLMSKEE
Protein: Fibroblast growth factor-binding protein 2b (Zgc:162825 protein) (A3KP08)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MCTLLNDPFVGLVFIKPDCTSNTSSVHYTFAMRSICSCAFLLVCFIWSTDAQNSSNHIEITQHSRPQPQPKANLWDEPIRFNTKAKDTCTMVISSQTNSTKLRVSCKSKGKSYWCDFLGKPNLCKSYNNNPRHYFTQIMWDLRKLHNACQGSKVYKPQMCRSASDEVQMVFHNSWPKNSVPKPTQSSQNQQKHQQQVKPSVPPTKPPTKQQLKPQQPAKAASKPAKTAASKPASPRKPVKAITVRPTVAEESQSVKMAEEYCWKSLQGVCAYFISWFQS
Protein: Telomere-binding protein subunit alpha (TEBP alpha) (Telomere-binding protein 56 kDa subunit) (P29549)
Organism: Sterkiella nova (Ciliate) (Oxytricha nova)
Function: May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.
Subcellular location: Nucleus. Chromosome, telomere.
Interaction partners:
Sequence:
MSTAAKQNRSTSRVSKKKTAAPKEGAAKKSDKGHKYEYVELAKASLTSAQPQHFYAVVIDATFPYKTNQERYICSLKIVDPTLYLKQQKGAGDASDYATLVLYAKRFEDLPIIHRAGDIIRVHRATLRLYNGQRQFNANVFYSSSWALFSTDKRSVTQEINNQDAVSDTTPFSFSSKHATIEKNEISILQNLRKWANQYFSSYSVISSDMYTALNKAQAQKGDFDVVAKILQVHELDEYTNELKLKDASGQVFYTLSLKLKFPHVRTGEVVRIRSATYDETSTQKKVLILSHYSNIITFIQSSKLAKELRAKIQDDHSVEVASLKKNVSLNAVVLTEVDKKHAALPSTSLQDLFHHADSDKELQAQDTFRTQFYVTKIEPSDVKEWVKGYDRKTKKSSSLKGASGKGDNIFQVQFLVKDASTQLNNNTYRVLLYTQDGLGANFFNVKADNLHKNADARKKLEDSAELLTKFNSYVDAVVERRNGFYLIKDTKLIY
Protein: Meiotically up-regulated gene 134 protein (O42654)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MNYNANVVKFHSTILHKFALKISKFLILCMRRNKRQLACMKCQCENPMAAITYADIEYPHNTHFLLLDSISWIPCTCKILKLKEFELPDRFDIPNLFYDGWLSYVFHTFSGVYLKIGYEMDESGFCLPDQVYHLIDNHSCIQTAVSHLLRNHQALFKYLCDYLRSGEFPLTVLIHHVMLYQYYPKSLQEALWAAVEHYVNNSGEAYSTVQKLAVQKKIGNIRMYLVNPRDIFALGSTCNCIVVSSSNFQSYVQLRKPLLENNLPYEIDGFDKILQCANSEADIGWIAMIHCIGSNGYAFPIHLYLNMKKNIFLGKLPESTLLLYNSDGAIFKNPPSSKKECDFYNQLLLDLCKCRQFNAEMECNMKKLFNNPTGLHSLPNLPNFSEAGSAKSSNFCSSKDNCLTNRLTLNCLDTPSDENGEDIAIQLIIPAE
Protein: Putative transcriptional regulator encoded by LINC00473 (A8K010)
Organism: Homo sapiens (Human)
Function: May play a role in cAMP-mediated gene transcription.
Interaction partners:
Sequence:
MELSAAAGRRRQAPWREFTGRHRTERSQERGSTPRKERSMGSRQPRKREREPRDCTPTCTNAASVSRSGARRAPGCAGRCITMKNCARAWRELSERACCFQAVPPSNMKQSWLIFLDTTLCSAWLLASSCPRLYAPLISFHCMCFNTVLLFPRLFGPTLSAKIQFNTDLSLRAIAWKCTKDTTTYC
Protein: 2-oxoglutarate dehydrogenase complex component E1 (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) (E9PCR7)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLDLAVFKERLRMLTVGGFYGLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPRSMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEHKNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDVFKNFS
Protein: Pentatricopeptide repeat-containing protein At2g15690, mitochondrial (Q9ZQE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000305|PubMed:25732537}.
Interaction partners:
- Chaperonin CPN60, mitochondrial
Sequence:
MSSLMAIRCARTQNIVTIGSLLQLRSSFPRLSSQFHFSGTLNSIPIKHLSTSAAANDYHQNPQSGSPSQHQRPYPPQSFDSQNQTNTNQRVPQSPNQWSTQHGGQIPQYGGQNPQHGGQRPPYGGQNPQQGGQMSQYGGHNPQHGGHRPQYGGQRPQYGGPGNNYQNQNVQQSNQSQYYTPQQQQQPQPPRSSNQSPNQMNEVAPPPSVEEVMRLCQRRLYKDAIELLDKGAMPDRECFVLLFESCANLKSLEHSKKVHDHFLQSKFRGDPKLNNMVISMFGECSSITDAKRVFDHMVDKDMDSWHLMMCAYSDNGMGDDALHLFEEMTKHGLKPNEETFLTVFLACATVGGIEEAFLHFDSMKNEHGISPKTEHYLGVLGVLGKCGHLVEAEQYIRDLPFEPTADFWEAMRNYARLHGDIDLEDYMEELMVDVDPSKAVINKIPTPPPKSFKETNMVTSKSRILEFRNLTFYKDEAKEMAAKKGVVYVPDTRFVLHDIDQEAKEQALLYHSERLAIAYGIICTPPRKTLTIIKNLRVCGDCHNFIKIMSKIIGRVLIVRDNKRFHHFKDGKCSCGDYW
Protein: Thyroid peroxidase (TPO) (EC 1.11.1.8) (P35419)
Organism: Mus musculus (Mouse)
Function: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Thyroglobulin
- Tyrosine 3-monooxygenase
- Aromatic-L-amino-acid decarboxylase
- Tyrosinase
- Aspartate aminotransferase, cytoplasmic
- Putative aspartate aminotransferase, cytoplasmic 2
- Aspartate aminotransferase, mitochondrial
- Thyrotropin receptor
- L-amino-acid oxidase
- Amine oxidase
Sequence:
MRTLGAMAIMLVVMGTVIFLSFILRSRDILCGKTMKSHVISAVETSQLMVDHAVYNTMKRNLKKREVLSPAQLLSFFKLPESTSGAISRAAEIMETSIQVMKREQSQFSTDALSADILGTIANLSGCLPFMLPPRCPDTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPKGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSSGTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDAGRAYLPFATAACAPEPGTPRTNRTPCFLAGDGRASEVPALAAVHTLWLREHNRLASAFKAINKHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVNPTVSNIFSTAAFRFGHATVHPLVRRLNTDFQEHTELPRLQLRDVFFRPWRLIQEGGLDPIVRGLLARAAKLQVQGQLMNEELTERLFVLSNVGTLDLASLNLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSMVNKIMDLYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENTNVFTDAQRQELEKHSLPRVICDNTGLTRVPVDAFRIGKFPQDFESCEDIPSMDLELWRETFPQDDKCVFPEEVDNGNFVHCEESGKLVLVYSCFHGYKLQGQEQVTCTQKGWDSEPPVCKDVNECADLTHPPCHPSAQCKNTKGSFQCVCTDPYVLGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLTWIVICRWTHADKKATLPITERVTTQSGCRKSQGRGISPHKAAAQDTGQEPASGSRVLLCE
Protein: Checkpoint kinase 2 (A0A3B3ITA7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVG
Protein: AT3G11560 protein (LETM1-like protein) (Q8H0W4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAARLQRPGLVSSSSTSKPCLPRMSIVTFISCKRTVHLEYLSNCLSNPRSQLFVRYGFLERSNKKKSQRLVLASAEDGVAINGSPQPRSSSNLEDMRTSFTGSLQDENNSNGLNQSLHDAARSIELAVKEKITPSRFSWFPSTWLGADKYAWVKTLSYQASLYSLLQAVNEISSRGNYRDEDINVFVQRSLSRQAAPLENMMRENLSSKHPKAYEWFWSEQVPSVVTSFVNYLEGDQRFVAATSVYAKGKSAAASNEIEVSLLMLVLNCIAAITKVGPAKFSCPPFFSMIPDTTGRLMEKLVDFVPLPQAYHSIKSIGLQREFLTHFGPRAAVCRVNGDIDTDEVIFWVDLIQKQLQRAIDREKIWSKLTTSESIEVLERDLAIFGFFIALGRSTQSILAANGFDSLENPLEDLVRHLIGGSVLYYPQLSAISSYQLYVEVVCEELEWIPFYPNNTGTQPPNQSHGHKTKPEGPPNYEVIPQLLDVCSYWLQSFIKYSKWPENPSNVKAAKFLSKGHKTLVRCKEELGILKNASSIVRESNSFDKALESVDEALVRLESLLQELYVSNSSSGKEQIKAACSDLEKIRKLKKEAEFLEATFRAKAASLQQGGDKNDSQESYEVQKRYFKGKDTKNANSSEDQGKSISRGFWGFFVRPSRKKLDPELSGDEYIGKSSGNLLSIDSEPIEISRFEILRNELIELEKRVKRSTDQSVDEEELISEDTPQSSSRTESVQLVQTPKKENMMEKTLQKLREATTDVWQGTQLLAIDSAAAVQLLRRSLIGDELTGKEKKALRRTMTDLASVIPIGILMLLPVTAVGHAAMLAGIQRYVPGLIPSTYGSERLNLLRQLEKIKELQTNETESEEGVEEIAL