wanglab/gogpt-training-data huggingface dataset:
Protein: AP-2 complex subunit sigma (Adaptin small chain) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin) (Q00381)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular location: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of the plasma membrane coated vesicles.
Interaction partners:
- AP-2 complex subunit alpha
- AP-2 complex subunit mu
- AP-2 complex subunit beta
- AP-1 complex subunit beta-1
- AP-1 complex subunit gamma-1
- Clathrin heavy chain
- Clathrin light chain
- AP-1 complex subunit mu-1-I
- AP-3 complex subunit delta
- AP-1 complex subunit sigma-1
Sequence:
MAVQFILCFNKQGVVRLVRWFDVHSSDPQRSQDAIAQIYRLISSRDHKHQSNFVEFSDSTKLIYRRYAGLYFVMGVDLLDDEPIYLCHIHLFVEVLDAFFGNVCELDIVFNFYKVYMIMDEMFIGGEIQEISKDMLLERLSILDRLD
Protein: Probable cysteine protease RDL5 (EC 3.4.22.-) (Cysteine protease 2) (AtCP2) (Probable cysteine proteinase At4g11320) (RD21A-like protease 5) (Q9SUS9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses protease activity in vitro.
Interaction partners:
- UPF0235 protein At5g63440
- CDPK-related kinase 4
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
- AT1G10660 protein
- Uncharacterized protein
Sequence:
MGYAKSAMLIFLLALVIASCATAMDMSVVSSNDNHHVTAGPGRRQGIFDAEATLMFESWMVKHGKVYDSVAEKERRLTIFEDNLRFITNRNAENLSYRLGLNRFADLSLHEYGEICHGADPRPPRNHVFMTSSNRYKTSDGDVLPKSVDWRNEGAVTEVKDQGLCRSCWAFSTVGAVEGLNKIVTGELVTLSEQDLINCNKENNGCGGGKVETAYEFIMNNGGLGTDNDYPYKALNGVCEGRLKEDNKNVMIDGYENLPANDEAALMKAVAHQPVTAVVDSSSREFQLYESGVFDGTCGTNLNHGVVVVGYGTENGRDYWIVKNSRGDTWGEAGYMKMARNIANPRGLCGIAMRASYPLKNSFSTDKVSVA
Protein: Protein phosphatase 1 regulatory subunit 15B (Constitutive repressor of eIF2alpha phosphorylation) (CReP) (Q8BFW3)
Organism: Mus musculus (Mouse)
Function: Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Protein phosphatase 1 regulatory subunit 15A
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- SH2/SH3 adapter protein Nck1
- Protein phosphatase 1 regulatory subunit 3B
- Leucine-rich repeat protein SHOC-2
Sequence:
METGTHRARKRPGPRLGSWFRLPFLRRSHACSSEFPPPSSRQNPGNSALPERRTRYWTKLLSQLLALLPSLFQKLLLWSQLFGGLIPTRWLDFAASYSALRALRGREESAAPTVQKSLSSLRLDSSEDLVVSSLDWLEEGLQWQCSSSDLELKLKAQERALDSAAPTFLLEQQLWGVELLPSSLQAGLVSHRELDSSSSGPLSVQSLGNFKVVSYLLNPSYLDYLPQLGLRCQSSAGGGQFVGFRTLTPESCYLSEDGCHPQPLRAEMSATAWRRCPPLSTEGLPEIHHLRMKRLEFLQANKGQELPTPDQDNGYHSLEEEHNLLRMDPQHCTDNPAQAVSPAADRPEPTEKKPELVIQEVSQSPQGSSLFCELPVEKECEEDHTNATDLSDRGESLPVSTRPVCSNKLIDYILGGAPSDLEASSDSESEDWGEEPEDDGFDSDGSLSESDVEQDSEGLHLWNSFHSVDPYNPQNFTATIQTAARIAPRDPSDSGTSWSGSCGVGSCQEGPLPETPDHSSGEEDDWEPSADEAENLKLWNSFCHSEDPYNLLNFKAPFQPSGKNWKGRQDSKASSEATVAFSGHHTLLSCKAQLLESQEDNCPGCGLGEALAGERYTHIKRKKVTFLEEVTEYYISGDEDRKGPWEEFARDGCRFQKRIQETEVAIGYCLAFEHREKMFNRLRIESKDLLLYSNVKK
Protein: Fibroblast growth factor 16 (FGF-16) (O54769)
Organism: Rattus norvegicus (Rat)
Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.
Subcellular location: Secreted {ECO:0000269|PubMed:9473496}.
Interaction partners:
- Fibroblast growth factor receptor
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor
- Fibroblast growth factor receptor 4
- Klotho
- Pro-epidermal growth factor
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 3
- Fibroblast growth factor 23
- Platelet-derived growth factor receptor alpha
Sequence:
MAEVGGVFASLDWDLQGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELFGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFRYR
Protein: Ncapg protein (B2RQA7)
Organism: Mus musculus (Mouse)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
Sequence:
MVLHDIVVAHVCYVKCSSSDLHLLYSVCFSYIQGFPVVNEEQKGDFTFIGDLMKREFIGQQLILIMKSLDTSEEGGRKRLLAILQETLILPTTPISLVSLIVERLLHIIRDDNERIQIVTEIISEIRAPIVNVVVDPSDTRKKELKMAEIKVKLIEAKEALENCIAVQDFDQASKLKEEIKILEDAKINLLKETEQLEIKEVHTEKNDAETLQKCLVLCYELLKQMSTSTGITATMNGIIESLILPGIISVHPIVRNLAVLCLGCCGLQNRDFASKHFMLFLQVLQIDDVTIKISALKAIIDQLMMFGIEPFKTQKVKGVQCEGEEINCHDKQEENDAGETDPAKSVLKLLSDFLDSEVSELRTGAAEGLAKLMFSGLLVSSRILSRLILLWYNPVTEEDVRLRHCLGVFFPMFAYANRTNQECFEEAFIPTVQTLANAPASSPLAEVDVTNVVELLVDLTRPSRLNPKAKNSQDYQALTVHDNLAIKICNEILTSPCSPENRVYTKALSLVELSSNVTKDLLLLLDEILEHVTDRTCLRALEKIKSQLGKGGKESDPGVVTQDVNTTTAVLQNENEYMTPVRDGKGTQTSKSTQGKSKRGCRKAPVSSKTNRRRQIAGPDSESDHEPPSEMKMRLPRRAKTAALQKSKLNLAEFLNEDTS
Protein: Delta(14)-sterol reductase TM7SF2 (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2) (Q8WMV1)
Organism: Bos taurus (Bovine)
Function: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Subcellular location: Microsome membrane {ECO:0000250|UniProtKB:Q71KT5}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11784322}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sterol-C5-desaturase
- Lanosterol 14-alpha demethylase
- Squalene monooxygenase
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Methylsterol monooxygenase 1
- Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
- Chromosome 14 open reading frame 1 ortholog
- Hydroxymethylglutaryl-CoA synthase
- Sigma non-opioid intracellular receptor 1
- Isopentenyl-diphosphate Delta-isomerase 1
Sequence:
MAPPQGSRAPLEFGGPLGAAALMLLLPVTMFHLLLVARSGPARLLGPPPYLPGPEELWSPWALLLCLTWLGLQAALYLLPARKVAEGQELKDKSRLRYPTNGFQALVLTALLVGLGVSAGLPLSALPEMLLPLAFAATLTAFIFSLLLYLKALLAPASALAPGGNSGNLIYDFFLGRELNPRICSFDFKYFCELRPGLIGWVLINLALLIQEAELRGSPSLAMWLVNGFQLLYVGDALWYEEAVLTTMDIIHDGFGFMLAFGDLAWVPFTYSLQAQFLLYHPQPLGWPLASFICLINAVGYYIFRGANSQKNTFRKNPSDPRVADLETISTATGRRLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVFHLLPYFYFLYFTALLVHREDRDERQCRQKYGLAWHEYCRRVPYRIVPYVY
Protein: T-cell receptor-associated transmembrane adapter 1 (T-cell receptor-interacting molecule) (TRIM) (pp29/30) (Q6PIZ9)
Organism: Homo sapiens (Human)
Function: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9687533}; Single-pass type III membrane protein {ECO:0000269|PubMed:9687533}.
Interaction partners:
- T-cell surface glycoprotein CD3 zeta chain
- Gamma-butyrobetaine dioxygenase
- T-cell surface glycoprotein CD3 delta chain
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface glycoprotein CD3 gamma chain
- E3 ubiquitin-protein ligase TRIM22
- Tyrosine-protein kinase ZAP-70
- T-cell surface glycoprotein CD8 alpha chain
- Tripartite motif-containing protein 5
- Lymphocyte transmembrane adapter 1
Sequence:
MSGISGCPFFLWGLLALLGLALVISLIFNISHYVEKQRQDKMYSYSSDHTRVDEYYIEDTPIYGNLDDMISEPMDENCYEQMKARPEKSVNKMQEATPSAQATNETQMCYASLDHSVKGKRRKPRKQNTHFSDKDGDEQLHAIDASVSKTTLVDSFSPESQAVEENIHDDPIRLFGLIRAKREPIN
Protein: Alpha-L-iduronidase (EC 3.2.1.76) (D-idua) (Q9VKJ8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential lysosomal hydrolase responsible for the degradation of the glycosaminoglycans (GAG) heparan sulfate and dermatan sulfate (Probable). Required for lysosome function and autophagy. Consequently, has an essential role in the development, maintenance and function of various cells, tissues, and organs, including the muscles and the central nervous system (CNS).
Subcellular location: Lysosome {ECO:0000250|UniProtKB:P35475}.
Interaction partners:
- N-sulfoglucosamine sulfohydrolase
- Sulfatase N-terminal domain-containing protein
- RE14504p
- Iduronate 2-sulfatase
Sequence:
MLSLLLVLTTLARIHAHYTSGDVVYHTMPHFWTGVGFCPAGRIDHEGISAALGDPALRLNLRLIAALPVGAVTHIRIHWLLELIQFWQYDPSGIPIYDFSKFDDFIDFLHEELRLSPVLEWMGNLGGVFSENPMQQSFYWEHLVKTTINHQIARHGSSRLVNWRYETWNEPDLRGYNKQNFTAHTFLDYVQAVRRGLSKAGNLDNQDGKVPLPMYRSLRGPAGLFKDSNHPLCWNLLELCSQRVVYCPIDILTFHRKGIEGTATEIVNGSLSLMAKIYEEYPNLKQLPVANDEADPVAGWSTSRDFQADVRYGITLISTVMQFWHAKLAGGPLSRLESISHDNAFLSYHPHEFTQRTLLAHFRMNETKPPHSQLVQKPVYAALGMLAKLGTRAADVEMVNMDTKHSVQVLRTVSGGLGGPGQYMATIFLSPEEAGPKMTAFHHKYTLNMSIANESAFVTELLVPKETDPYYIWQQAGSPAYPNATLREAMRRAQAPRLYKTGPIWQYNSELVINSASIPLPWAMLLRVCSASWPKLRRPQQLSIAEVTQREVFISWMEHPKSTQCLLSYEVWFKERDNLGRSADWMLISQGWHLPYPSFQYAPGDKGSVNGFYKVRGVDVFNETSPYSQIVEYLEL
Protein: T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (P80314)
Organism: Mus musculus (Mouse)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P78371}.
Interaction partners:
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit zeta-2
- Chaperonin containing TCP1 subunit 8-like 1
- Protein FAM161B
Sequence:
MASLSLAPVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDAALMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIISGWREATKAAREALLSSAVDHGSDEARFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDPRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESFAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGHITAGLDMKEGTIGDMAVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC
Protein: Zinc finger protein 540 (Q8NDQ6)
Organism: Homo sapiens (Human)
Function: May act as a transcriptional repressor.
Subcellular location: Nucleus {ECO:0000269|PubMed:16815308}. Cytoplasm {ECO:0000269|PubMed:16815308}.
Interaction partners:
Sequence:
MAHALVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCVVARDVTGRQCPGLLSRHKTKKLSSEKDIHEISLSKESIIEKSKTLRLKGSIFRNEWQNKSEFEGQQGLKERSISQKKIVSKKMSTDRKRPSFTLNQRIHNSEKSCDSHLVQHGKIDSDVKHDCKECGSTFNNVYQLTLHQKIHTGEKSCKCEKCGKVFSHSYQLTLHQRFHTGEKPYECQECGKTFTLYPQLNRHQKIHTGKKPYMCKKCDKGFFSRLELTQHKRIHTGKKSYECKECGKVFQLIFYFKEHERIHTGKKPYECKECGKAFSVCGQLTRHQKIHTGVKPYECKECGKTFRLSFYLTEHRRTHAGKKPYECKECGKSFNVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLRVHSRIHTGEKPYECKECGKAFMLRSVLTEHQRLHTGVKPYECKECGKTFRVRSQISLHKKIHTDVKPYKCVRCGKTFRFGFYLTEHQRIHTGEKPYKCKECGKAFIRRGNLKEHLKIHSGLKPYDCKECGKSFSRRGQFTEHQKIHTGVKPYKCKECGKAFSRSVDLRIHQRIHTGEKPYECKQCGKAFRLNSHLTEHQRIHTGEKPYECKVCRKAFRQYSHLYQHQKTHNVI
Protein: CurH (Q6DNE5)
Organism: Lyngbya majuscula
Interaction partners:
Sequence:
MLNKFTKKEQILSEKQQIKQLSPLQRAALALKKLETKLNNTLHEPIAIIGMSCRFPGGASSPEKFWQLLQGGSSARSQIPRERWNIEAYYDPDPDAPGKMLTCHGHFVDNVDQFDPEFFGISPREATAMDPQHRLLLEVSWEALEQGGQVLERLEEAAVGVFIGNDGRDYEQLLQQHLQQEPESPLVTYAGTGNALSNAAGRLAYTFGFTGPTVTIDTACSSSLVAIHQACNSLRLGECQMALAGGVKLHLTPNSYIDASKARMICADGQCKTFDISADGFGRGEGCGMVLLKRLSDAQADGDQIVAVIRGSAVNQDGPSSGLTVPNGQSQQRLIKQALAQAQVKPSEISYLEAHGTGTSLGDPIEVNAVVAVLGEDRTPEYPLWMASVKTNIGHLEAAAGVSGLIKVVLSLQHRLLPAHLNLHQPNPKIDWQPWLQVPKQLTPWEVSGHRLAGVSSFGFTGTNAHVVIEEAPSSQKSPQVERERPWNILALSAKNQEALLQLVQSYSQHLERAPEQELVDICFTANTGRLSYIHRLSLVAATKAELQERLKAFGTEEEVTGLVSGVVSGGESPKVAMLFTGQGSQYVGMGRQLYETQPTFRKALEQCAEILQPYLDRHLLEVLYSLEAEESVLEQTAYTQPALFALEYALFQLWQSWGIKPDVVMGHSVGEYVAATVAGVWSLEDGLKLIAARGRLMQQLPSGGEMFSVMASESKVRETLKEMALGEQVAIAAINGPQSIVISGESEAVRAIATNLESETIKTKQLQVSHAFHSPLMEPMLVEWEALANQIAYNQPKIPIISNVTGTTADSSITTAQYWVNHVRQPVRFAQSMEALDKLGSEVFLEVGPKPILLGMGRQCLPEGVGVWLPSLRPGVDAWQQMLLSLGQLYVQGVKVDWLGFDRDYARQKVTLPTYPFQRERYWVEAPKTVVLSGQQVHRLLGNKLELASTGQTIYHQDINLNNHPWIGDHRVYDTPVIPGVSYIAMTLAAVGVPAAVEDINFQQPLFLAESNTTRETQLMLHTADNVGKQFVEVFSRDGAKQEEWQQHASMSVSENPPPPPTLSVDIPALCEQLRPLDTDTLTEIYASISLVYGPMLQAVRQAWIGEETSLLEIEVPKALAFQLAGEPIHPVLIDACTRLTPDLFDFSSDSGVFWAPWRVKEMTLSHPTPSRFYAYVEEPSRVNEQLQTRSYDIQLLDETGQAFGRINGFTVKRAPSQLFLKSLQPDVSNWLYQLQWQPSEVKETVPLATSRMWLLFVPEGVWAEQLTSSLAQLDQQYVVVSPGDDFRYLSEYHYQVCPTQKESFQQLLQKIVEKGVTLQGVVHLWSLLSDSQQLNQAQELVCGSTLHLIQALGEVFDSQVPPLWLVTQGAQCIAAQTTIHVQQSPLWGLGRVIALEHPEFKCHRVDLDPDNASIAEGVEMLLQELLAPDAEDQVAYRQGERHVARLERFVPQSSGEYPQQLRLRAYGTLDNLVLQPQQRRQPERGEVEIQVRAVGLNFRDVLTALGMMQEYTQHLFDSAEQVVFGGECAGVVVAVGSDVEHLQVGDEVVLALAIGCLAHYMTIPADLALPKPQHLSFEAAATLPTAFITAHYGLNYLANLQPGERVLIHSAAGGVGQAAVQLVQNRGAEVFATASPPKWKFLQQQGVEQIMNSRTLEFAEQVQAATEDMGVDVVLNSFNEEYIPQSFQALAHGGRFIEIGKINIWSQSKAQEYRPDVKYEVFDLVEMVREQPELVAQLWSELGTELKTGKLQPLPHQVFELGQVHEAFRYLQQAKHIGKVVVAIPPLREQKKEIQAQGSYLVTGGLGALGLEVSKWLVDKGARHLVLMGRRSPSAEAQIKIAQLEDMGVKVSVQLADVSCSQQVSQMMERIERELPSLRGVIHAAGVLDDGVLQNMSWQQFVKVMLPKVQGTWHLHQLTKDLPLDFFVCFSSMSSLLGNLGQGNYAAANEFMDAVAHYRRSMGLPGLSINWGAWASSGMAASLAGQHQQRLETIGIRAIEPQQGMQALGSLLSQTPSQVGVLPINWSKFVSTLPGGQKMPFLEALISTEPSLTQKSAFREQLEAAAVSERQELLTNHIRSAIAKALGWRDGQKIGMRQPLFDLGLDSLMAVELKNRLESSLETNLSSTLLFDYPTVEALVEYLANDVIPIEFSSNLDEIENLEQEEIDNTFRFQEMSEDEMANILARKLESLEGKKS
Protein: Probable DNA replication complex GINS protein PSF2 (GINS complex subunit 2) (Q9VQY9)
Organism: Drosophila melanogaster (Fruit fly)
Function: The GINS complex plays an essential role in the initiation of DNA replication.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA replication licensing factor Mcm7
- DNA replication licensing factor Mcm5
- DNA replication licensing factor Mcm3
- CDC45L
- DNA replication licensing factor Mcm6
- DNA replication complex GINS protein PSF3
- DNA replication complex GINS protein PSF1
- DNA replication licensing factor MCM4
- DNA replication licensing factor Mcm2
- DNA replication complex GINS protein SLD5
Sequence:
MDPSIIEFIGEKCMISIIPNFSNEPLHLIYGPVGPFRAGFPVFVPLWMATHLRKQQKCRIVPPEWMDMDILEEIKEEEKRSKFFTKMPCEHYMVVAQLVMSTAPDDVPRCEELRTVIKDIFDIRESKLRTSIDAFIKGEGTYAKLDNLTLLEIHSVRPILPYSLDHIARYQRTATASQRDTSMLSASMAGSSSGPNSNSLFSQ
Protein: Homeodomain-like superfamily protein (F4IB54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTESIDLNRLESESDNNTDDVTPIFAIDDSAKGYFSLNRRNDVQCQHRWLKVLDPSLQKGAWKKEEDKLLSELVKNYICNYVYIFLSILFNYNKKSNINSYFFGTSKRIKFIIFLFYK
Protein: Leucine-rich repeats and immunoglobulin-like domains protein sma-10 (Q965M2)
Organism: Caenorhabditis elegans
Function: Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20502686}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000305|PubMed:20502686}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:20502686}.
Interaction partners:
- Cell surface receptor daf-4
- Serine/threonine-protein kinase receptor sma-6
- SMAll.
- Repulsive guidance molecule B homolog drag-1
- Protein dbl-1
- Cell surface receptor daf-1
- Protein lon-1
Sequence:
MIVYSLLLLILYDFLPKVVTFDTVCIGLCHCVGNVVDCSSLDLSEIPTTIPNNTRILLLSDNEIESIDKSRLKGFYFLQTLDISNNIIRHIDFEFFYNLPNLKILNIRKNRLARIPRGSHELGHLEKLDLRSNLISTVTSEELSYLAAVRSVDLSRNLISYLPKPTTSAKVNIEKLDLASNSITDIGTDHFSSFNTLVTLKLARNHITTLNQFSFSRLRKLESLDLTRNMIREVRFLAFNQLPSLQNVSLARNDVYRLDDGMFYACEGLKHLNLSTNRVQAVTEGWMFGLTSLEVLDLSYNQIQSFHISSWSHTPKLKWLSLHSNRIQSLPSGSFRVLRQLEELILSANSIDSLHKFALVGMSSLHKLDLSSNTLAVCVEDGAVLYNTSMPFLRSLRFTNNQLRVIPKRAFERFPALEELDLTDNPIATIHPEAFEPLELKRLVMNSSSILCDCQISWLASWIYRLKLDKSSIIAKCSYPPPLADLYVVAIDTANLTCHNDSPRAKIVRQPVEVSTLIGEKARFTCNVYGASPLSIEWRVMENGQPRVLVQDSATFLSINRTAVVNGTFDERELAAAELLLDNVAMTDNSEYQCVARNRFGSDFSTHVKLQVYQAPKFTYTPEDMPLLVGQTAKFLCAATGTPRPEIKWAFEQIPFPAAEARRLYVTPNDDHIYIMNVTKEDQGAYTCHATNVAGQTQASANLIVFENFFHYPESPDLSPMLIKKRDALKIDCSCDLISSRQRMVWKRQQQVILFLKKAKFSDNDQILTLTQTTFSDSGEYSCELWVDDTILMRKITMVKVVNEDEFVSSEATLTQRVQRIRAMASKLVDNIKSTGNGIYLMASCSAFGLMILGVITSICICIAKCSCNQNHVFNVLPVQV
Protein: Autophagy-related protein 8i (Autophagy-related ubiquitin-like modifier ATG8i) (AtAPG8i) (Protein autophagy 8i) (Q9LRP7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.
Subcellular location: Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P38182}; Lipid-anchor {ECO:0000250|UniProtKB:P38182}. Vacuole membrane {ECO:0000250|UniProtKB:P38182}; Lipid-anchor {ECO:0000250|UniProtKB:P38182}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8LEM4}.
Interaction partners:
- Protein NBR1 homolog
- Autophagy-related protein 3
- Ubiquitin-like modifier-activating enzyme atg7
- Cysteine protease ATG4b
- Cysteine protease ATG4a
- Autophagy-related protein 18b
- Serine/threonine-protein kinase ATG1c
- Serine/threonine-protein kinase ATG1b
- Ubiquitin-like protein ATG12A
- Ubiquitin-like protein ATG12B
Sequence:
MKSFKEQYTLDERLAESREIIAKYPTRIPVIAEKYCKTDLPAIEKKKFLVPRDMSVGQFIYILSARLHLSPGKALFVFVNNTLPQTAALMDSVYESYKDDDGFVYMCYSSEKTFG
Protein: T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (P42943)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit gamma
- Phosducin-like protein 2
- Prefoldin subunit 4
- Actin
Sequence:
MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQGAGRGRGMPM
Protein: PTPRF interacting protein alpha 1 (A0A1B0GWM2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MMCEVMPTISEAEGPPGGGGSHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQMVLLMHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNSQKKALTEGMLDGNHEQENAPSTNGKRSSDGSLSHEDLAKVLELQEVIDRQAREQSQMKERLASLSSHAAELEEDLDTARKDLIKSEEMNTKLQREVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKSGPLSSGSSAAKEAKLLELTSKLRKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVENAKKQLEETQHDKDQLVLNIEALKAELEQMRLRGSSLHHGRPHLGSVPDFRFSVADGHVDAYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDVDVSDGEDDRDTLLSSVDLLSPSGQADAQTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLAGSSPPGSGRSTPRRVPHSPAREVDRLGVMTLPSDLRKHRRQLPASREEVRDDKTTIKCETSPPSSPRPLRLDRLHKGALHTVSHEDIRDLRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGPLGKESPGQAGVSETENSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTTGNVWLTHEEMETLTATPQTEDEEGSWAQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQNETRDVLVWSNDRVIRWILSIGLKEFANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVTGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLASGSAETLPANFRVTSSMSSPSMQPKKVQMDGSVSGAQRLDSATVRTYSC
Protein: Protein serin-threonin phosphatase (Q8DGS1)
Organism: Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)
Interaction partners:
- Serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase B
- non-specific serine/threonine protein kinase
- Serine/threonine protein kinase
- Serine/threonine protein kinase
- Serine/threonine protein kinase
- Serine/threonine protein kinase
- non-specific serine/threonine protein kinase
Sequence:
MDVAGLTDCGLIRKSNQDAFYIDEKHQRFFIVADGMGGHAGGEEASRLAVDHIRQYLETHLEDLQHDPVTLLRQAFLAANHAIVEQQRQNSARADMGTTAVVILLDEKGDRAWCAHVGDSRIYRWRKDQLQQITSDHTWIAQAVQLGSLTIEQARQHPWRHVLSQCLGREDLSQIDIQPIDLEPGDRLLLCSDGLTEELTDDVISIYLSEPNVQKAAAALVDAAKTHGGRDNVTVVVISV
Protein: Disabled homolog 1 (mDab1) (P97318)
Organism: Mus musculus (Mouse)
Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9338785}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 8
- Very low-density lipoprotein receptor
- Amyloid-beta precursor protein
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Reelin
- Tyrosine-protein kinase Fyn
- Crk-like protein
- SH3 domain-containing kinase-binding protein 1
- Phosphatidylinositol 3-kinase regulatory subunit gamma
- Phosphatidylinositol 3-kinase regulatory subunit beta
Sequence:
MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPNSQPLEDFESRFAAATPNRNLSMDFDELLEATKVSAVTQLELFGDMSTPPDITSPPTPATPGDAFLPSSSQTLPGSADVFGSMSFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQIAMGAQPPVAQVIPGAQPIAWGQPGLFPATQQAWPTVAGQFPPAAFMPTQTVMPLAAAMFQGPLTPLATVPGTNDSARSSPQSDKPRQKMGKESFKDFQMVQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHVSDPTADDIFEEGFESPSKSEEQEAPDGSQASSTSDPFGEPSGEPSGDNISPQDGS
Protein: Ankyrin 1 (A0A8I6GAS7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MAERPRRSGSDPAADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTSMVKLLLENDASPNLATTAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVQLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVSDKHRMSYPETVDEILDVSEDEGDELVGSKAERRDSRDVGEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIRSEDQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHKSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLRSKLVPLVQATFPENAVTKKVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVHFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAIPVKVRDSSREPGGFLSFLRKPMKYEDAQHILCHLNVTMPPCTKGSGAEDRRRTLTPLTLRYSILSESRLGFTSDTDRVEMKMAVIREHLGLSWAELARELQFSVEDINRIRVENPNSLLDQSTALLTLWVDREGENAKMENLYTALRNIDRSEIVNMLEGSGRQSRNLKPDRRHGDREYSLSPSQVNGYSSLQDELLSPASLHYALPSPLCADQYWNEVAVIDAIPLAATEHDTMLEMSDMQVWSSGLTPSLVTAEDSSLECSKAEDSDAIPEWKLEGAHSEDTQGPELGSQDLVEDDTVDSDATNGLADLLGQEEGQRSEKKSQEVSGTEQDTETEVSLVSGQQRVHARITDSPSVRQVLDRSQARTVDWYKQGSAASYPQEAAQSSWQEEVTQGPQSFQRRITTIQGPEPGTLQEYEQVVVSTREHVQRGPPESDSPKAGKDPSLWASESAFSQEVQGDELQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQVDSSGAIDTQQHEEVELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ