wanglab/gogpt-training-data huggingface dataset:
Protein: Eukaryotic translation initiation factor 4E (D6RBW1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKKKQNKKERKKMRAEDGENDAIKKQAESLRESQETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
Protein: MARVEL domain-containing protein (Q27GU4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTTTSFGSLISQNETSFPAGYSQRNSMATSERMGAFGEMRHTPSPGTQKLRVDMSSSGSTPVSKVETPILPSSSMSQHPPNNPFPRGSQSYNSSGSTPLRVNTSNRSSANSQRPLLPPQDRPVRFQTNGHLQPSVYMPTTHSQADSSESRRKHDKLSDVYSQSGDTVEFAKNLSDYINEKIPYQISIAVLSCFSLLAFLLIIFGLLNAPFCAIQPMIPIWLIVEGVLFIISATFRIYFLIPTPRRTAYRRQQRQLGASLLCKGLEILFALANIVWLILGCVWVYGSKAFVHFNEGMFERHYCDPTIYWSAFFACTAFLIFYCVIIFLVICLLIVGSVKESSSQDQNLD
Protein: Small nuclear ribonucleoprotein SmD3a (SmD3-a) (snRNP core protein D3-a) (Q9S7E6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). May play a minor role in the splicing of cellular pre-mRNAs.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62318}. Nucleus {ECO:0000250|UniProtKB:P62318}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000250|UniProtKB:P62318}.
Interaction partners:
- Probable small nuclear ribonucleoprotein G
- Probable small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein Sm D2
- U2 small nuclear ribonucleoprotein A'
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein E
- U1 small nuclear ribonucleoprotein C
- Sm-like protein LSM8
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein SmD1a
Sequence:
MSRSLGIPVKLLHESSGHIVSVEMKSGELYRGSMIECEDNWNCQLENITYTAKDGKVSQLEHVFIRGSLVRFLVIPDMLKNAPMFKDVRGKGKSASLGVGRGRGAAMRAKGTGRGTGGGRGAVPPVRR
Protein: Gamma-soluble NSF attachment protein (N-ethylmaleimide-sensitive factor attachment protein gamma) (Q9U6R9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
- Alpha-soluble NSF attachment protein
- Vesicle-fusing ATPase 2
- Syntaxin 8
- Golgi SNAP receptor complex member 1
- LD03592p
- LD27967p
- HL02043p
- Syntaxin 16
- LD27581p
- Syntaxin-5
Sequence:
MSGIAAKKIAEAEDLVKQAEKSLKLSMLKWVPDYDSAADEYSKAATAYRIAKSYDKSKECFLKAIDAYKNNKSWFHAAKAYEQIILLSKDADKLHEVEEYANKSASLYQQHGSPEAAASALDKAAKLTESKHPDMALRFYQHALEVIMIEDSVRQAAEYASKVSRILVKLRRYDEATNALKKEISLNQQTESYGQIGRLVVALVMVQLARGDSVEAEKTFREWGNCCEPEEVSTLQTLLQAFDDEDPELAARMLASPFIRHMDVEYAILSKNIPLPQGIQMEKKAGDTAAETNDAEDEGGLC
Protein: AT4G31170 protein (AT4g31170/F6E21_90) (Protein kinase superfamily protein) (Protein kinase-like protein) (Q9M085)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MLENPKFDLHAVGNHNNDNNYYAFTQDFYQKLGEEGTNMSVDSMQTSNAGGSVSMSVDNSSVGSSDALIGHPGLKPMRHPYSLSDGQSVFRPGKVTHALNDDALAQALMDSKYPTEGLVNYEEWTIDLRKLHMGPAFAQGAFGKLYRGTYNGEDVAIKLLERSDSNPEKAQALEQQFQQEVSMLAFLKHPNIVRFIGACIKPMVWCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVMQALDVARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPEVRPCFAEIVNLLEAAETEIMTNVRKARFRCCMTQPMTVD
Protein: Uncharacterized protein YhdP (P46474)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Probable phospholipid transport protein YdbH
- Rod shape-determining protein MreD
- AsmA family protein YicH
- dTTP/UTP pyrophosphatase
- AsmA family protein YhjG
- Protein AsmA
- Regulator of RpoS
- Protein RseC
- Lipid A palmitoyltransferase PagP
Sequence:
MRRLPGILLLTGAALVVIAALLVSGLRIALPHLDAWRPEILNKIESATGMPVEASQLSASWQNFGPTLEAHDIRAELKDGGEFSVKRVTLALDVWQSLLHMRWQFRDLTFWQLRFRTNTPITSGGSDDSLEASHISDLFLRQFDHFDLRDSEVSFLTPSGQRAELAIPQLTWLNDPRRHRAEGLVSLSSLTGQHGVMQVRMDLRDDEGLLSNGRVWLQADDIDLKPWLGKWMQDNIALETAQFSLEGWMTIDKGDVTGGDVWLKQGGASWLGEKQTHTLSVDNLTAHITRENPGWQFSIPDTRITMDGKPWPSGALTLAWIPEQDVGGKDNKRSDELRIRASNLELAGLEGIRPLAAKLSPALGDVWRSTQPSGKINTLALDIPLQAADKTRFQASWSDLAWKQWKLLPGAEHFSGTLSGSVENGLLTASMKQAKMPYETVFRAPLEIADGQATISWLNNNKGFQLDGRNIDVKAKAVHARGGFRYLQPANDEPWLGILAGISTDDGSQAWRYFPENLMGKDLVDYLSGAIQGGEADNATLVYGGNPQLFPYKHNEGQFEVLVPLRNAKFAFQPDWPALTNLDIELDFINDGLWMKTDGVNLGGVRASNLTAVIPDYSKEKLLIDADIKGPGKAVGPYFDETPLKDSLGATLQELQLDGDVNARLHLDIPLNGELVTAKGEVTLRNNSLFIKPLDSTLKNLSGKFSFINSDLQSEPLTASWFNQPLNVDFSTKEGAKAYQVAVNLNGNWQPAKTGVLPEAVNEALSGSVAWDGKVGIDLPYHAGATYNIELNGDLKNVSSHLPSPLAKPAGEPLAVNVKVDGNLNSFELTGQAGADNHFNSRWLLGQKLTLDRAIWAADSKTLPPLPEQSGVELNMPPMNGAEWLALFQKGAAESVGGAASFPQHITLRTPMLSLGNQQWNNLSIVSQPTANGTLVEAQGREINATLAMRNNAPWLANIKYLYYNPSVAKTRGDSTPSSPFPTTERINFRGWPDAQIRCTECWFWGQKFGRIDSDITISGDTLTLTNGLIDTGFSRLTADGEWVNNPGNERTSLKGKLRGQKIDAAAEFFGVTTPIRQSSFNVDYDLHWRKAPWQPDEATLNGIIHTQLGKGEITEINTGHAGQLLRLLSVDALMRKLRFDFRDTFGEGFYFDSIRSTAWIKDGVMHTDDTLVDGLEADIAMKGSVNLVRRDLNMEAVVAPEISATVGVAAAFAVNPIVGAAVFAASKVLGPLWSKVSILRYHISGPLDDPQINEVLRQPRKEKAQ
Protein: Probable dihydrofolate synthetase (DHFS) (EC 6.3.2.12) (Q9UTD0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Glutamate-adding enzyme which catalyzes the binding of the first glutamyl side chain to dihydropteroate. Leads to the de nove synthesis of tetrahydrofolate. de novo (By similarity).
Interaction partners:
- Folic acid synthesis protein fol1
- Dihydrofolate reductase
- Probable thymidylate synthase
- Putative aminodeoxychorismate synthase
- Probable folylpolyglutamate synthase
- Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase
- Probable GTP cyclohydrolase-2
- Methylenetetrahydrofolate dehydrogenase [NAD
- Branched-chain-amino-acid aminotransferase, mitochondrial
- 6,7-dimethyl-8-ribityllumazine synthase
Sequence:
MPIQLGLQRMLQLLKHLGNPQESFCAVQIAGTNGKGSICSYIYTSLLQAAIKTGRYTSPHFLEPRDTISINGQIASEEIFNTCWKQVIEVDRRFRTKATEFELLTATAFQCFHHSGVRVAVIETGMGGRLDATNVFEEPVLSIISRICLDHQAFLGNTLEAIAKEKAGIFKKNVPCVVDGLNEVNVLNQLKLSAEETRAHPFYLAKGKSGENKNEWIINTPNWGTNTFSTPLKGDYQGQNLACAVTALDILSSSFSIMLPHVQNGVKNTSWPGRLDIRSVPSLGDILFDGAHNKEAAIELAKFVNSQRREHNKSVSWVVAFTNTKDVTGIMKILLRKGDTVIATNFSSVSGMPWIKSMEPEVIKNSISSESSVECYTADNLTISEILRLAKEKNSSVIVCGSLYLLGDMYRYLKLDV
Protein: DUF1471 domain-containing protein (Multiple stress resistance protein BhsA) (Putative outer membrane protein) (A0A0F7J832)
Organism: Salmonella typhimurium
Interaction partners:
Sequence:
MKNVKTLIAAAVLSSLSFASFAAVEVQATPEGQQKFGTISANGGTNLGSLEDQLAQKAQEMGAKSFRITSVTGPNTLHGTAVIYK
Protein: Accumulates dyads protein 3 (Q07732)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the pathway that organizes the prospore membrane (PSM) during sporulation. Mediates the assembly of the DON1 ring structure at the leading edge of PSM during meiosis II. May constitute a physical link between SSP1-containing PSM precursors and the spindle pole body (SPB) and may facilitate the recruitment of other factors that are required to promote spore wall formation.
Subcellular location: Prospore membrane. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes to the leading edge, which cover the ring-shape opening of the PSMs during meiosis II. Colocalizes with DON1 to dots in the cytoplasm and at the SPB. Its localization to the PSMs but not to the SPBs depends on SSP1.
Interaction partners:
- Donuts protein 1
- Sporulation-specific protein 1
- Sporulation-specific protein 21
- Uncharacterized protein IRC10
- Meiotic plaque component protein 54
Sequence:
MNHWLAFLNKPESLKEQNSDCDQQGEMRHVTDGTLTKSPESKPFRERRSQTWIDSEVPTSTEKSNVQESISSDIISKLSNRRSRRNRSESWAGSEASSPSGNISTLENATEKNTLKSPNKFLQRGGLPTVGIGSQALSPAGKPSTLGNVSPGKFTTYKVHNSIEVNRFSSTPTKLLTNPHKVAAISNDEHYVVSNESLEENIEVAHLENVFRSSKTPDEEQSEYMKLGEIRLSSSSYGGSISKENSLPKVLDELQSQNEEIKALRQKLEEKDDRIQELEELNSMNDAKLQRIEDLQKEFHNERKAASKRLNIVQDRFRKEIKKIREEKITDFQNKNASKKEKNEVTSAKTKCKAFSQRNILVSELYRKQKQILNLQQENDKFLKDINESNNSIVKLRSEVEILKSNLQLSQDENKKLHDNGSFYEKRLNDVYSYMQNLSLFEKDLGKFILEEMKCGHSPSMFQNGFAKLYPDFQDIKNLENMEQYKQLKGKIELLEKNDRIRLEKIISVFKLINERLHFMQQQHSHKIKYLQKEALTKEQQFRLEKRRWHDILNLKEENFQKLKSELKEKLILSEKIQKNAEDKLNDYMNEHQEIVEKLQNQALIASRWSTQIQESENTHKKITDELAGKQSEILKLEETILSLKEDVFQEKLNLKKLYGDPSTELNFETVGKSFPHITKEKYDSLGLDILTDLTYVQSQNLIKNLLIVLDIPLKTFLKIVPTIVIQLRCELTLLTKFANDLNLKVFGKQLDFKSRRKVAMNEFLNNHDIAEVKHPLEYDLQALFKYFFS
Protein: Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) (O43829)
Organism: Homo sapiens (Human)
Function: Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.
Subcellular location: Nucleus {ECO:0000269|PubMed:15629158}. Note=Colocalizes with ZBTB21 in nucleus in HEK293 cells.
Interaction partners:
- Cell cycle checkpoint protein RAD1
- Checkpoint protein HUS1
- Checkpoint protein HUS1B
- Activity-dependent neuroprotector homeobox protein
Sequence:
MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDENNGQSKSKYCLKINRPIGDAADTQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS
Protein: Fibronectin type III and SPRY domain-containing protein 2 (SPRY domain-containing protein 1) (A1L4K1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:H0UZ81}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:H0UZ81}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:H0UZ81}. Note=In skeletal muscles and striated muscles flanks Z-disks. Partially colocalizes with RYR2 in the sarcoplasmic reticulum. {ECO:0000250|UniProtKB:H0UZ81}.
Interaction partners:
Sequence:
MEEESGEELGLDRSTPKDFHFYHMDLYDSEDRLHLFPEENTRMRKVVQAEMANESRGAGDGKAQRDLQEEVDELVHLYGLEDDHELGDEFVDENIPRTGVSEYPPYMMKRRDPAREQRDWRLSGEAAEAEDLGFGGWGSAGQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQIIEMENFANHLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDVEISAQPEFEDQTLDFSDVEQLMGSINTIPAPSAPVINPQVPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSPGTDQAEFTVTVKETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSERAVYMTAPSPPIIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVGIPTCESVVQLQPGRSYIIYVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISEDGLTAVRSERRTPARELSPSDTHFTRCVAVMGNLIPVRGHHYWEVEVDEHLDYRVGVAFADVRKQEDLGANCLSWCMRHTFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHEFVHPCFSLEKPGCLKVHNGISMPKHVTFY
Protein: Soluble lytic transglycosylase B (Q9HX24)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Peptidoglycan D,D-transpeptidase MrdA
- Endolytic peptidoglycan transglycosylase RlpA
- Membrane-bound lytic murein transglycosylase D
- Membrane-bound lytic murein transglycosylase F
- Endolytic peptidoglycan transglycosylase RlpA
- Peptidoglycan glycosyltransferase MrdB
- Endolytic murein transglycosylase
- serine-type D-Ala-D-Ala carboxypeptidase
- N-acetylmuramoyl-L-alanine amidase
- N-acetylmuramoyl-L-alanine amidase
Sequence:
MKNAMQVLRTWAARGVQWVGVAGVIGLSGAAQAGDYDGSPQVAEFVSEMTRDYGFAGEQLMGLFRDVNRKQSILDAISRPAERVKQWKEYRPIFISDARISRGVDFWNKHAEDLARAEKEYGVPAEIIVSIIGVETFFGRNTGSYRVMDALSTLGFDYPPRADFFRKELREFLLLAREQQVDPLSLTGSYAGAMGLPQFMPSSFRAYAVDFDGDGHINIWSDPTDAIGSVASYFKQHGWVTGEPVVSVAEINDESAESAVTRGVDPTMSLGELRARGWRTHDALRDDQKVTAMRFVGDKGIEYWVGLPNFYVITRYNRSAMYAMAVYQLAGEIARARGAH
Protein: Adenylate kinase (EC 2.7.4.3) (ATP-AMP transphosphorylase) (ATP:AMP phosphotransferase) (Adenylate kinase cytosolic and mitochondrial) (Adenylate monophosphate kinase) (P07170)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
Subcellular location: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:12045196, ECO:0000269|PubMed:2850178}. Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:12045196, ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:22984289, ECO:0000269|PubMed:2850178}. Note=90% cytoplasmic, 10% mitochondrial. {ECO:0000269|PubMed:2850178}.
Interaction partners:
- Adenosine kinase
- Adenylosuccinate lyase
- Adenine phosphoribosyltransferase 1
- Nucleoside diphosphate kinase
- Adenine phosphoribosyltransferase 2
- AMP deaminase
- Ribonucleoside-diphosphate reductase large chain 1
- Ribonucleoside-diphosphate reductase large chain 2
- Ribonucleoside-diphosphate reductase small chain 2
- Ribonucleoside-diphosphate reductase small chain 1
Sequence:
MSSSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGKD
Protein: T cell receptor beta variable 7-9 (P04435)
Organism: Homo sapiens (Human)
Function: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular location: Cell membrane {ECO:0000303|PubMed:20452950}.
Interaction partners:
Sequence:
MGTSLLCWMALCLLGADHADTGVSQNPRHKITKRGQNVTFRCDPISEHNRLYWYRQTLGQGPEFLTYFQNEAQLEKSRLLSDRFSAERPKGSFSTLEIQRTEQGDSAMYLCASSL
Protein: Embryonic ectoderm development (E9PJK2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSASCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
Protein: GH07506p (Q9W1I7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
Interaction partners:
Sequence:
MHSTSYFVAATCAALLLLAATAQSTAAAQSGLQPGGKLIELDEDNWHLMLQGEWMIEFFAPWCPACKNLAPTWERFARVAKDVQVQVAKIDVTTSPSLSGRFFVTALPTIYHVKDGEFRQYRGARDGDALLYFVKKQQWQSIEPLSAWKKPDTTHMSVLSYFFKLSHTLKDFNGRLQEEYGLPTWGSYALFAIATIFVGAALGLLLVCLVDFVYPPKKSQRQSFSESQDNLTEGLEDLATEEIEDDGDAEENDDEQRDSDEEEQEDDDEEEEDSEEQVGDLATKEKEADSEPEKEEKPEPKQAGDAAPEKTEQVRKRKPRKGD
Protein: Calcium-binding protein J (Q55C62)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Probable serine/threonine-protein kinase roco11
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase qkgA
Sequence:
MGAGNTKLSKEEINELIKKTNYTKDQIDKLSKDYNEYSSKDKKSGFTESEFIDFFYCRFRDWDKDLLIQLFKLFDTDCNGILDFKEFVTSLYIMTKAPVVEKLSLLFDLFDKDQSGHLEVDEVEKLIGVAVACGTSLGMDYSGVTNYVFSICSAENMSNKKKGMNKEEFIKAASNSDKFCKMICFYDSMGQMLY
Protein: Cathepsin L1 (EC 3.4.22.15) (Cysteine proteinase 1) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] (Q95029)
Organism: Drosophila melanogaster (Fruit fly)
Function: Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion.
Subcellular location: Lysosome {ECO:0000269|PubMed:9099581}.
Interaction partners:
- Cathepsin D
- cathepsin L
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- LP12231p
- RE02351p
- MIP16848p
- Peptidase A1 domain-containing protein
Sequence:
MNHLGVFETRFRPRTRHKSQRAQLIPEQITMRTAVLLPLLALLAVAQAVSFADVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV
Protein: Small ribosomal subunit protein eS30A (40S ribosomal protein S30-A) (P0CT62)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein eS27
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS28A
- mRNA export factor elf1
- Elongation factor 3
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL6
Sequence:
MGKVHGSLARAGKVKSQTPKVEKQEKPKQPKGRAYKRLLYVRRFVNVTNMVGGKRRMNPSS
Protein: Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2) (C6K2K4)
Organism: Rattus norvegicus (Rat)
Function: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Glutamate receptor ionotropic, kainate 2
- Lysine--tRNA ligase
- Solute carrier family 12 member 5
Sequence:
MALEQLCAVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHVPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDERYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGMKSPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSAIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLFTSFVEPPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGLFEQITKTHGTIIGVTSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLREKEISADLADLSEELDNYQKLRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQTHDCPEQALEDRVMEEIPCEIYVRGRDDSAQASISIDF
Protein: Alpha-ketoglutarate-dependent dioxygenase FTO (EC 1.14.11.53) (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (mRNA N(6)-methyladenosine demethylase FTO) (tRNA N1-methyl adenine demethylase FTO) (A0A1B0GVH5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELREYQSTINTVLPGGISCFKFASQICCRVKSHYVAQAGLEFLASNSWPQAILLPQPPKALGLQV
Protein: 60S ribosomal protein L9, putative (Q38CD0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 60S ribosomal protein L17, putative
- 60S ribosomal protein L35, putative
- 60S ribosomal protein L19, putative
- 60S ribosomal protein L5, putative
- 60S ribosomal subunit protein L31, putative
- 60S ribosomal protein L6, putative
- 60S ribosomal protein L13a, putative
- 60S ribosomal protein L27a
- 60S ribosomal protein L7a
Sequence:
MKIKSHDQITFPEDVTVSVKDRIVTVKGKRGTLTKDLRHLQLDFRVNKKLRTFTAVRWFGNKINNSTINTALSHVRNMITGVTKGFRFKVRFAYAHFPISVTVENQLVEIRNFLGEKRVRRQVVADDVKVYRTDAALVKDELVLEGNDLEQVSREAAVMHQLCLVKKKDIRKFLDGIYVQTKTNIEVDE
Protein: Probable coatomer subunit zeta (Zeta-coat protein) (Zeta-COP) (O17901)
Organism: Caenorhabditis elegans
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Interaction partners:
- Probable coatomer subunit gamma
- Coatomer subunit epsilon
- Probable coatomer subunit delta
- Probable coatomer subunit beta'
- Coatomer subunit beta
- Coatomer subunit alpha
- Beta'-coat protein
- ADP-ribosylation factor 1-like 2
- Coatomer WD associated region domain-containing protein
- Uncharacterized protein F07F6.4
Sequence:
MADFDTNPTSLYSIKGIVILDQDGNRVLAKYYDRTTFGTVKEQKAFEKSLFSKTSRNTSADILLLDGVTCLYRSNVDLYFYVLGSTRENELFLDATLTCLYDAVSVVLRKNVEKKALIDSMDTIMLIIDEICDEGIIMETDAQAVVQRTALKSDEVSFSDQSVSQIGFSFMKSANEQFKWSLLK