Protein: Erythronolide synthase EryA3 (EC 2.3.1.94) (6-deoxyerythronolide B synthase III) (6-deoxyerythronolide-B synthase EryA3, modules 5 and 6) (DEBS 3) (ORF C) (Q03133)
Organism: Saccharopolyspora erythraea (Streptomyces erythraeus)
Function: Involved in the biosynthesis of antibiotic erythromycin via the biosynthesis of its aglycone precursor, 6-deoxyerythronolide B (6-dEB).
Interaction partners:
Sequence:
MSGDNGMTEEKLRRYLKRTVTELDSVTARLREVEHRAGEPIAIVGMACRFPGDVDSPESFWEFVSGGGDAIAEAPADRGWEPDPDARLGGMLAAAGDFDAGFFGISPREALAMDPQQRIMLEISWEALERAGHDPVSLRGSATGVFTGVGTVDYGPRPDEAPDEVLGYVGTGTASSVASGRVAYCLGLEGPAMTVDTACSSGLTALHLAMESLRRDECGLALAGGVTVMSSPGAFTEFRSQGGLAADGRCKPFSKAADGFGLAEGAGVLVLQRLSAARREGRPVLAVLAGSAVNQDGASNGLTAPSGPAQQRVIRRALENAGVRAGDVDYVEAHGTGTRLGDPIEVHALLSTYGAERDPDDPLWIGSVKSNIGHTQAAAGVAGVMKAVLALRHGEMPRTLHFDEPSPQIEWDLGAVSVVSQARSWPAGERPRRAGVSSFGISGTNAHVIVEEAPEADEPEPAPDSGPVPLVLSGRDEQAMRAQAGRLADHLAPEPRNSLRDTGFTLATRASAMEHRAVVVGDRDEALAGLRAVADRRIADRTATGQGPNSPRRVAMVFPGQGAQWQGMARDLLRESQVFADSIRDCERALAPHVDWSLTDLLSGARPLDRVDVVQPALFAVMVSLAALWRSHGVEPAAVVGHSQGEIAAAHVAGALTLEDAAKLVAVRSRVLRRLGGQGGMASFGLGTEQAAERIGRFAGALSIASVNGPRSVVVVAGESGPLDELIAECEAEAHKARRIPVDYASHSPQVESLREELLTELAGISPVSADVALYSTTTGQPIDTATMDTAYWYANLREQVRFQDATRQLAEAGFDAFVEVSPHPVLTVGIEATLDSALPADAGACVVGTLRRDRGGLADFHTALGEAYAQGVEVDWSPAFADARPVELPVYPFQRYWLPIPTGGRARDEDDDWRYQVVWREAEWESASLAGRVLLVTGPGVPSELSDAIRSGLEQSGATVLTCDVESRSTIGTALEAADTDALSTVGVAAVPHGEAVDPSLDALALVQALGAAGVEAPLWVLTRNAVQVADGELVDPAQAMVGGLGRVVGIEQPGRWGGLVDLVDADAASIRSLAAVLADPRGEEQVAIRADGIKVARLVPAPARARTHPLEPLAGTVLVTGGTGGIGAHLARWLARSGAEHLVLLGRRGADAPGASELREELTALGTGVTIAACDVADRARLEAVLAAEAAAEGRTVSAVMHAAGVSTSTPLDDLTEAEFTEIADVKVRGTVNLDELCPDLDAFVLFSSNAGVWGSPGLASYAAANAFLDGFARAARSEGAPVTSIAWGLWAGQNMAGDEGGEYLRSQGLRAMDPDRAVEELHITLDHGQTSVSVVDMDRRRFVELFTAARHRPLFDEIAGARAEARQSEEGPALAQRLAALLCDGREREHLAHLIRAEVAAVLGHGDDAAIDRDRAFRDLGFDSMTAVDLRNRLAAVTGVREAATVVFDHPTITRLADHYLERLVGAAEAEQAPALVREVPPKDADDPIAIVGMACRFPGGVHNPGELWEFIVGGGDAVTEMPTDRGWDLDALFDPDPQRHGTSYSRHGAFLDGAADFDAAFFGISPREALAMDPQQRQVLETTWELFENAGIDPHSVRGSDTGVFLGAAYQGYGQDAVVPEDSEGYLLTGNSSAVVSGRVAYVLGLEGPAVTVDTACSSSLVALHSACGSLRDGDCGLAVAGGVSVMAGPEVFTEFSRQGGLAVDGRCKAFSAEADGFGLPEGVAVVQLQRLSDGPAEGGRQVLGVVAGSAINQDGATNGLAAPSGVAQQRVIRKAWARAGITGADVAVVEAHGTGTRLGDPVEASALLATYGKSRGSSGPVLLGSVKSNIGHAQAAAGVAGVIKVVLGLNRGLVPPMLCRGERSPLIEWSSGGVELAEAVSPWPPAADGVRRAGVSAFGVSGTNAHVIIAEPPEPEPLPEPGPVGVLAAANSVPVLLSARTETALAAQARLLESAVDDSVPLTALASALATGRAHLPRRAALLAGDHEQLRGQLRAVAEGVAAPGATTGTASAGGVVFVFPGQGAQWEGMARGLLSVPVFAESIAECDAVLSEVAGFSASEVLEQRPDAPSLERVDVVQPVLFSVMVSLARLWGACGVSPSAVIGHSQGEIAAAVVAGVLSLEDGVRVVALRAKALRALAGKGGMVSLAAPGERARALIAPWEDRISVAAVNSPSSVVVSGDPEALAELVARCEDEGVRAKTLPVDYASHSRHVEEIRETILADLDGISARRAAIPLYSTLHGERRDMGPRYWYDNLRSQVRFDEAVSAQSPDGHATFVEMSPHPVLTAAVQEIAADAVAIGSLHRDTAEEHLIAELARAHVHGVAVDWRNVFPAAPPVALPNYPFEPQRYWLAPEVSDQLADSRYRVDWRPLATTPVDLEGGFLVHGSAPESLTSAVEKAGGVVPVASADREALAAALREVPGEVAGVLSVHTGAANALALHQSLGEAGVRAPLWLVTSRAVALGESEPVDPEQAMVWGLGRVMGLETPERWGGLVDLPAEPAPGDGEAFVACLGADGHEDQVAIRDHARYGRRLVRAPLGTRESSWEPAGTALVTGGTGALGGHVARHLARCGVEDLVLVSRRGVDAPAAAELEAELVALGPKTTITACDVADREQLSKLLEELRGQGRPVRTVVHTAGVPESRPLHEIGELESVCAAKVTGARLLDELCPDAETFVLFSSGAGVWGSANLGAYSAANAYLDALAHRRRAEGRAATSVAWGAWAGEGMATGDLEGLTRRGLRPMAPDRAIRALHQALDNGDTCVSIADVDWEAFAVGFTAARPRPLLDELVTPAVGAVPAVQAAPAREMTSQELLEFTHSHVAAILGHSSPDAVGQDQPFTELGFDSLTAVGLRNQLQQATGLALPATLVFEHPTVRRLADHIGQQLDSGTPAREASSALRDGYRQAGVSGRVRSYLDLLAGLSDFREHFDGSDGFSLDLVDMADGPGEVTVICCAGTAAISGPHEFTRLAGALRGIAPVRAVPQPGYEEGEPLPSSMAAVAAVQADAVIRTQGDKPFVVAGHSAGALMAYALATELLDRGHPPRGVVLIDVYPPGHQDAMNAWLEELTATLFDRETVRMDDTRLTALGAYDRLTGQWRPRETGLPTLLVSAGEPMGPWPDDSWKPTWPFEHDTVAVPGDHFTMVQEHADAIARHIDAWLGGGNS