wanglab/gogpt-training-data huggingface dataset:
Protein: Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1) (Q9HA47)
Organism: Homo sapiens (Human)
Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Interaction partners:
- Uracil phosphoribosyltransferase homolog
- Uridine phosphorylase 2
- Uridine 5'-monophosphate synthase
- Uridine-cytidine kinase 2
- Uridine phosphorylase 1
- Cytidine deaminase
- Uridine-cytidine kinase-like 1
- Soluble calcium-activated nucleotidase 1
- Ectonucleoside triphosphate diphosphohydrolase 8
- UMP-CMP kinase 2, mitochondrial
Sequence:
MASAGGEDCESPAPEADRPHQRPFLIGVSGGTASGKSTVCEKIMELLGQNEVEQRQRKVVILSQDRFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVRRGRDLEQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDICKWHRGGSNGRSYKRTFSEPGDHPGMLTSGKRSHLESSSRPH
Protein: Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (A4IFW2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Catenin beta-1
- Catenin, beta 2.
- Leucine-rich repeat-containing 4Ba.
- Leucine-rich repeat-containing 4Bb.
- Tyrosine-protein kinase receptor.
- Tyrosine-protein kinase receptor
- Insulin receptor substrate 1
- Insulin receptor substrate 2a.
- Insulin receptor substrate 2
- Insulin receptor substrate 2-B
Sequence:
MVPNTCTSVPLLPVGLPLLLLLSCIQFSSQADSLPNFVRSPEDQTGISGGVASFVCQAAGEPKPRITWMKKGKKVSSQRFEVIEFDDGSGSVLRIQPLRTHRDEAIYECTATNSLGEINTSAKLTVLEENQIPHGFPTIDMGPQLKVVERTRTTTMLCAASGNPDPEITWFKDFLPVDINGNGRIKQLRSGALQIENSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEVMPGGSVNLTCVAVGAPMPYVKWMTGEVELTKDEEMPVGRNVLELTNIRQSTNYTCVAISSLGMIEATAQVSVKALPKPPTSLTVTETTATSVTLTWDSGNPEPVSYYIIQYRAKTSDTNFQEVDGVATTRYSIGGLSPYSEYEFRVMAVNNIGRGPPSEPVETRTGEQAPSSPPLHVQARMLSASTMLVQWEPPEEPNGQIRGYRIYYTSDLDAPLSAWQKHNTDDSRLTTISSLTTGITYSLRVLGFTSVGDGPPSDVLQVKTQQGVPAQPSSFEAEAELDTRILLTWLWPVQDPIIKYELQYWEADSDNKIHVTFDPAGSYAVEGLKPDTLYKFSLAARSEMGQGVFTHPIEARTAQSAPSAPPQDVHLLSLSSTSIKVSWVAPPAASRHGAIVRYTVSYQAVNGEDTERHEVPDIGADASSCVLEGLEKWTEYQVWVRAHTDVGPGPESTAVRIRTNEDVPGAPPRKLEVEALNSTAIRVTWKPPLSGKQHGQIRGYQVIYSRLENGEPRGHPNIMDVALPEAQWKIEESTEYEAVIAGLASETSYSVTVAAYTTKGDGARSKAKVVTTTGAVPGKPTMIISTTVGNTALIQWQPPKDMVGELMGYRLRYKRLEEENYEIREFSRTDDHHTVTDLHKGATYSFHLSARNRAGLGEEYVKDIGTPEDVPSGFPLNLQVVGLTTSTTRLTWEPPALSERNGRIIHYIVVYRDINSKQNSTNRTSDTQMTIQGLRPDTTYDIRVQAFTSKGGGPISPSIQSRTMSTSPAFATSFGVKAVMKTSVLLTWEVPENYKSQVPFKILYNQQSVEVQGNLKRKLITRLQPDTDYSFVLMSRGNSAGGLQQQVSIRTAPDLFKTKPVLYTADQTNNGKLTINLPKVPTSAPVRCYYIVVVPVSQTSSRQWINPDEMELDELLESSEGAHLRRRRRHTDTVRPYIAAKLSTLPETFTLGDELDYSGFINRPLPNNQHFQCFVMAELKDQYPVTANEKQRTFSASPYSDPIIVQGENQMQRSVDQPEMLWVMGPVLAVVLIIIIVIAILLFKRKRASPLPKDDHSGGVKDCLLASSSDPVEMRRLNYQTPGMREHPPISVSELADHIERLKANDALRFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVVLTPVDGVPGSDYINSNYIDGYRKQNAYIATQGPLPETLSDFWRMIWEQRASTIVMMTRLEEKSRVKCDQYWPIRGTETYGMIQVTMLDAVELATYSVRTFALYKNGSSEKREVRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYIFIHEALLEAATCGNTEVPARNLYAHIQKLTQPSAGETVTAMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPFESTRVCLQPIRGVEGSDYINASCIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDLFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q8T8Y2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAKQEATNGKVRNASLHLEKLLIGGKYRLVKPIGSGSFGDIYLGLSITDGSEVAIKVEKNDAKYPQLIYEAKVYEQLARCPGFPTLLHYGCEKNYNAMVMDLLGPSLEELFNLCKRRFSLKTVLMLTDQLLMRIECVHERGFIHRDIKPDNFLMGLDRHCNKLYLIDFGLSKRYKDIESEIHIPYRTDRNLTGTVRYASINAQIGVEQSRRDDMESMSYCLMYFNLGKLPWQGITAANKKQKYEKILEKKTSVTIAQLCKGFPSEFCLLMTYVRNLGFKEPPDHTYLRQIFRILFRSLNHHYDYIYDWTALQQQKDQICRSREQILESEREEVRKRDGERGCDPQRDKERHKDLELDRLHKTSTQQAKCSNGHLTNRYDRIGDGGISKRK
Protein: Embigin (O88775)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates (By similarity). Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20695846, ECO:0000269|PubMed:9169423}; Single-pass type I membrane protein {ECO:0000305|PubMed:19473976, ECO:0000305|PubMed:9169423}. Synapse {ECO:0000250|UniProtKB:P21995}. Note=Localizes to the neuromuscular junctions. {ECO:0000250|UniProtKB:P21995}.
Interaction partners:
- Monocarboxylate transporter 2
- Monocarboxylate transporter 1
- Monocarboxylate transporter 4
Sequence:
MRSHTGLRALVAPGCSLLLLYLLAATRPDRAVGDPADSAFTSLPVREEMMAKYANLSLETYNISLTEQTRVSEQNITLERPSHLELECTFTATEDVMSMNVTWKKDDALLETTDGFNTTKMGDTLYSQYRFTVFNSKQMGKYSCFLGEELRGTFNIRVPKVHGKNKPLITYVGDSTVLKCECQNCLPLNWTWYMSNGTAQVPIDVHVNDKFDINGSYANETKLKVKHLLEEDGGSYWCRAAFPLGESEEHIKLVVLSFMVPLKPFLAIIAEVILLVAIILLCEVYTQKKKNDPDDGKEFEQIEQLKSDDSNGIENNVPRYRKTDSGDQ
Protein: Stress-activated protein kinase JNK (EC 2.7.11.24) (A4QP40)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU368052}.
Interaction partners:
Sequence:
MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHGRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDCLFPADSEHNKLKASQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHSIDEWKELIYKEVMNFEERTKNGVVKGQPSPSAQVQP
Protein: Forkhead box protein F2 (Protein LUN) (O54743)
Organism: Mus musculus (Mouse)
Function: Probable transcription activator for a number of lung-specific genes. Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q12947}.
Interaction partners:
Sequence:
MSTEGGPPPPPPRPPPAPLRRACSPAPGALQAALMSPPPAATLESTSSSSSSSSASCASSSSNSVSASAGACKSAASSGGAGAGSGGTKKATSGLRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHGQGGYGGLDMMPAGYDTGAGAPGHAHPHHLHHHHVPHMSPNPGSTYMASCPVPAGPAGVGAAAGGGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHPSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM
Protein: Cytochrome P450 monooxygenase patH (EC 1.-.-.-) (Patulin synthesis protein H) (m-cresol hydrolase) (A1CFL5)
Organism: Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria. PatH catalyzes the conversion of m-cresol into m-hydroxybenzyl alcohol. The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A075TRL5}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEPMLLLILVAAVVLLFVRWAFVYGHRTSNMPKGPPTLPFIGNIHQIPTQYTHIKFTEWAAKYGGLYMLKVGNGNMAVVTDRRLVKEVVDRKSGIYSHRPHSFVSHELITKGNHLLVMHYGDQWRTFRRLIHQHLMESMVDSQHVKIVNAEAIQLVRDYLVDPEHHMAHPKRFSNSITNSIVFGIRTADRNGSNMKRLYKLMEEWSEIMETGATPPVDLFPWMKMLPQWMFSNYVNRAKAIGVQMETLYTDILNKVIKRRNGGQNLGTFMDRVLDGQEKNDLPWHQLAFIGGVLMEGGSDTSSSLTIAIVQALILNPAVQKKAHAEIDAVVGSDRSPVWEDLEKLPYINMIIKEGHRWRPILPLCFPHALGEDDWVDGKLLPKGTVVVINTWGMHMDPSQPDDPAAFIPERYANHPQLAPEYAAGKWENRDHYGYGVGRRICPGIHLAERNMFLAIAKLLWAFEFQRGEGKIDSDPVTGYHNGFLYCAKDYPCRPVVRNKTIRATIEREFATATKEVFSQFTEG
Protein: Dynactin subunit 1 (E7EX90)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}.
Interaction partners:
Sequence:
MSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS
Protein: Candida glabrata strain CBS138 chromosome K complete sequence (B4UN36)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Ubiquitin-like modifier HUB1
Sequence:
MSGRQGGKAKPLKQKKKQQQDLDPEDQAFKEKQKADAAAKKAMMANVKSGKPLVGGGIKKSGKK
Protein: Sog2p (Q59WC1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Hym1p
- non-specific serine/threonine protein kinase
- CBK1 kinase activator protein MOB2
- Serine/threonine-protein kinase CBK1
- Cas4p
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Ubiquitin-binding ESCRT-I subunit protein
Sequence:
MSRSQIVALLKEQLDTIKQKKSIKLNSLPSTTKPSELIDTIYEFLTSFDPSLELEKLAIQNSQLIELPSNFHKIASSIKYLDLHQNSISYIPQDFFYGFDSLEILDLASNDLEFLPDSLSSVTTLKVISIKDNSFKYISPQLGELPNLNLIEVSGNPSLLPSNDIIRAFQQQKPDLDWVGELKNYLVANRMLINSKIQEAMEKSSQKRQQVPKDSTPETSQTTSDPVIARSKSGSISTSFSSKASRRMGLIIKKSDENSDGSSKEDANNSLISGAVPDHVTTEGIPHVDSPTDISFQLPKSPPTSTPGTTTPSTQAAPATTSTNKNLGVTSTSSARGRSNTFKEIDRMLEKSESVDTERKSNAYFKRLSTLQELPGDELSEYSQPKKPAAEGKQASGNVSKSNNTAASENSPAKPQQQSKLHTNPVIIRVSRKILFSFSELHSSIRRFTSFCSDKKVTMKMVSYLYSTKSNIDSLVENLEIMEESGDNSEQIVQALHNCIGSFKSIMKLLHENIQSFVGNIEVCFIRMVYLSVFGSLNELQNAYLLLCPKASAKSSSTEMKQKLSINTTTDADEKLYSTIESATSSTQTIFSELNKTINKGATASANGGVVHPTVASKIKELAKVCAASLDIIKRLNTKLITIRNNPSVTTKKLFAEDINQFIKTVVQTLAAVKAIVKDIPILDDIRASMSNLTKTAKEVTYFLEVSSYKSLLPDSSSTGVSQQPQLISVPSVSNLFTPVAAHAPSLPTSGGQAASNGPTPIRNPSTNSSITTTTLVLPPLNLQESAPLTAPVQSSGQMFAKHGLNPFDGLIMARNNDNQG
Protein: Sperm acrosome membrane-associated protein 3 (Q05C28)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000256|ARBA:ARBA00004312}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004312}.
Interaction partners:
Sequence:
MTSGWTDTGDTAWLTAYALPYAGVCLAYFTSGFNAAALDYEADGSTNNGIFQINSRRWCSNLTPNVPNVCRMYCSDLLNPNLKDTVICAMKITQEPQGLGYWEAWRHHCQGKDLTEWVDGCDF
Protein: Large ribosomal subunit protein uL16m (39S ribosomal protein L16, mitochondrial) (Q9W547)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ribosomal protein
- Mitochondrial ribosomal protein S11
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein bS16m
- Mitochondrial ribosomal protein L2
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS12m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL19m
Sequence:
MLSLKLVSQLFKQSLASGNMAIVNTAGLKYFAPPIKYQNVEQPERPKLRVIERQPQLPPNIRPPKMQKRLRYMRGPEMVHNTLLHKQYAIVATGGGRLRWGHYEMMRLTIGRKMNVNTMFATWRVPAPWQPITKKGQGQRMGGGKGAIDHYVTPIKAGRVIVEIAGKCEFVEVKQFLQQVANQLPFQATVVSQEMLDEQRVAEEEQTRQNENPFTMKYVIQNNLSGCHRWLSPVDHKWFGKHL
Protein: Protein RCC2 homolog (Q6NYE2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (By similarity). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9P258}. Nucleus {ECO:0000250|UniProtKB:Q9P258}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9P258}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9P258}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9P258}. Chromosome {ECO:0000250|UniProtKB:Q9P258}. Midbody {ECO:0000250|UniProtKB:Q9P258}. Cell membrane {ECO:0000250|UniProtKB:Q9P258}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9P258}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9P258}.
Interaction partners:
- Cell division cycle 20 homolog
- Serine/threonine-protein kinase PLK
- NudC nuclear distribution protein.
- Uncharacterized protein.
Sequence:
MPRKKVTDVSGNGGLKRKRGGGKKKEREFSSDDEFDDYEQENTKKPGKPAAKAGLQPVTVADDVKEKIKLEVPKVKGQLLIFGATNWDLIGRKEVPKQQAAFRNLGQNLWGPHRYGCLSDVQVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQYNGQPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVAIFIEKTKDGQVLPVPNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYCGYQCSFALSEMGGLFFWGVTNTSRESTMYPKAVQDLCGWKIRSLACGKSSIIVAADDSTISWGPSPTFGELGYGDNKPKSSTTAQEVKTLDGVYSEQVVMGYSHSLVIARQDTEQEKEKLKKLPEYNPRTL
Protein: Serine protease inhibitor A3K (Serpin A3K) (Contrapsin) (SPI-2) (P07759)
Organism: Mus musculus (Mouse)
Function: Contrapsin inhibits trypsin-like proteases.
Subcellular location: Secreted.
Interaction partners:
- Murinoglobulin-1
- Major urinary protein 3
- Transcription factor PU.1
- Carboxylesterase 3B
- Carboxylesterase 3A
- Murinoglobulin-2
- Estradiol 17 beta-dehydrogenase 5
- Cytochrome P450 2C50
- UDP-glucuronosyltransferase
- Major urinary protein 2
Sequence:
MAFIVAMGMILMAGICPAVLCFPDGTKEMDIVFHEHQDNGTQDDSLTLASVNTDFAFSLYKKLALKNPDTNIVFSPLSISAALALVSLGAKGKTMEEILEGLKFNLTETPEADIHQGFGNLLQSLSQPEDQDQINIGNAMFIEKDLQILAEFHEKTRALYQTEAFTADFQQPTEAKNLINDYVSNQTQGMIKELISELDERTLMVLVNYIYFKGKWKISFDPQDTFESEFYLDEKRSVKVPMMKMKLLTTRHFRDEELSCSVLELKYTGNASALLILPDQGRMQQVEASLQPETLRKWRKTLFPSQIEELNLPKFSIASNYRLEEDVLPEMGIKEVFTEQADLSGITETKKLSVSQVVHKAVLDVAETGTEAAAATGVIGGIRKAILPAVHFNRPFLFVIYHTSAQSILFMAKVNNPK
Protein: inositol-3-phosphate synthase (EC 5.5.1.4) (Q38AQ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Inositol-1-monophosphatase
- Inositol-1-monophosphatase
Sequence:
MPAVRTKSGHGVEYTDEAITATYSYNTTRVEKEANGDVTVQPIQLHLKFRTQRKVQRTGVMLIGWGGNNGTTVTAALMAHKHGVSWRTKTGTKQPDYLGSITQSSTMSVGLTSEMEEVFVPMKALVPMINPAELVIGGWDCSGMNIADAMRRAQVLDVTLQDALYNYLKDMHPLPAAFDLDFVAENQLSRADNIMQTKNKWESVEQLRADIRNFREKNSLEEVIVLWTANTERFSEHITGVHDTADHLIDAIRRNENEIAPSVLYATAAIMEGCSYINGAPQNTLCTGLIELARRHGVFVVGDDFKSGQTKVKSGLVEFFMDAGIKPECIASYNHLGNNDGYNLAAPKQFRSKEVTKGGVLDDMVSSNSILYPPGSRGPDHCIVIKYLPYVGDSKRALDEYNFSIFMGGEQTVVLHNTCQDSLLAAPLIIDLVVLTELMHRVTVTQCDGEGCCDKKEKMTSYTHMETVLSLLSYLLKAPRVPEGTPVVNGLNRQGQAIKNVLRALVGLPPDNNMQLECRLPFLRGVGS
Protein: Beta-1,2-xylosyltransferase (AtXYLT) (EC 2.4.2.38) (Q9LDH0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glycosyltransferase involved in the xylosylation of N-glycans. Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the core beta-linked mannose of N-glycans. Involved in the biosynthesis of glycoprotein bound N-glycans. Does not require metal ions for its activity.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:12175019, ECO:0000269|PubMed:12943552}; Single-pass type II membrane protein {ECO:0000269|PubMed:12175019, ECO:0000269|PubMed:12943552}. Note=Localizes in medial cisternae of Golgi apparatus. {ECO:0000269|PubMed:12943552}.
Interaction partners:
- Glycoprotein 3-alpha-L-fucosyltransferase A
- Putative fucosyltransferase-like protein
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Alpha-mannosidase 2
- Alpha-
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Beta-1,3-galactosyltransferase GALT1
- Probable beta-1,4-xylosyltransferase IRX9H
- Probable beta-1,4-xylosyltransferase IRX10
- Beta-1,4-xylosyltransferase IRX9
Sequence:
MSKRNPKILKIFLYMLLLNSLFLIIYFVFHSSSFSPEQSQPPHIYHVSVNNQSAIQKPWPILPSYLPWTPPQRNLPTGSCEGYFGNGFTKRVDFLKPRIGGGGEGSWFRCFYSETLQSSICEGRNLRMVPDRIVMSRGGEKLEEVMGRKEEEELPAFRQGAFEVAEEVSSRLGFKRHRRFGGGEGGSAVSRRLVNDEMLNEYMQEGGIDRHTMRDLVASIRAVDTNDFVCEEWVEEPTLLVTRFEYANLFHTVTDWYSAYVSSRVTGLPNRPHVVFVDGHCTTQLEETWTALFSGIRYAKNFTKPVCFRHAILSPLGYETALFKGLSGEIDCKGDSAHNLWQNPDDKRTARISEFGEMIRAAFGLPVNRHRSLEKPLSSSSSSASVYNVLFVRREDYLAHPRHGGKVQSRLINEEEVFDSLHHWVATGSTGLTKCGINLVNGLLAHMSMKDQVRAIQDASVIIGAHGAGLTHIVSATPNTTIFEIISVEFQRPHFELIAKWKGLEYHAMHLANSRAEPTAVIEKLTEIMKSLGC
Protein: Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 7.1.1.8) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Rieske protein UQCRFS1) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 9 (Su9) (Subunit 9) (8 kDa subunit 9) (Complex III subunit IX) (Cytochrome b-c1 complex subunit 11) (UQCRFS1 mitochondrial targeting sequence) (UQCRFS1 MTS) (Ubiquinol-cytochrome c reductase 8 kDa protein)] (P47985)
Organism: Homo sapiens (Human)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:31883641}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q5ZLR5}.
Interaction partners:
- Cytochrome b
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome c oxidase subunit 1
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Cytochrome b-c1 complex subunit 7
Sequence:
MLSVASRSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLDLKRPFLSRESLSGQAVRRPLVASVGLNVPASVCYSHTDIKVPDFSEYRRLEVLDSTKSSRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG
Protein: Recombination protein RecR (P0CB76)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
Interaction partners:
Sequence:
MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSADDVNEFAKNLLSAKRELTYCSICGRLTDDDPCSICTDPTRDQTTILVLEDSRDVAAMENIQEYHGLYHVLHGLISPMNGISPDDINLKSLMTRLMDSEVSEVIVATNATADGEATSMYLSRLLKPAGIKVTRLARGLAVGADIEYADEVTLLRAIENRTEL
Protein: D-arabinose dehydrogenase [NAD(P)+] heavy chain (EC 1.1.1.117) (AKR3C) (P38115)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the oxidation of D-arabinose, L-xylose, L-fucose and L-galactose in the presence of NADP(+).
Subcellular location: Cytoplasm.
Interaction partners:
- D-arabinose 1-dehydrogenase
- NADPH-dependent aldose reductase GRE3
Sequence:
MSSSVASTENIVENMLHPKTTEIYFSLNNGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWPVLWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKGISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFASLTKDELQELNDFGEKYPVRFIDEPFAAILPEFTGNGPNLDNLKY