wanglab/gogpt-training-data huggingface dataset:
Protein: Histamine-gated chloride channel alpha1 subunit (Histamine-gated chloride channel subunit 1) (Histamine-gated chloride channel subunit 2) (Histamine-gated chloride channel subunit A) (IP02838p) (Ora transientless) (Q9VDU9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Histamine-gated chloride channel subunit 1
- Histidine decarboxylase
Sequence:
MVFQIIILVICTICMKHYAKGEFQQSLAITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVFYEYL
Protein: Putative monooxygenase YdhR (EC 1.-.-.-) (P0ACX3)
Organism: Escherichia coli (strain K12)
Function: May function as monooxygenase and play a role in the metabolism of aromatic compounds.
Interaction partners:
- Probable quinol monooxygenase YgiN
Sequence:
MATLLQLHFAFNGPFGDAMAEQLKPLAESINQEPGFLWKVWTESEKNHEAGGIYLFTDEKSALAYLEKHTARLKNLGVEEVVAKVFDVNEPLSQINQAKLA
Protein: Large ribosomal subunit protein bL33m (39S ribosomal protein L33, mitochondrial) (L33mt) (MRP-L33) (Q9CQP0)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:O75394}.
Interaction partners:
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein bL12m
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL17m
Sequence:
MLLSAVSFAKSKSKTILVKLVSQAGTGFSFNHKRSRLREKLSLLHYDPIVNKKVLFVEQKKIRSL
Protein: Spire type actin nucleation factor 1 (J3KNG6)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004180}.
Interaction partners:
Sequence:
METELCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKSAKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIEYQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSSKSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYMSSPGPSEYCPSERTISEI
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 (H7C051)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
EEMPTACPGHSPRSQMALTGISPPLAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQETPAHSSGQPPRDAKLEAKTAKASPSGQNISYIHSSSESVTPRTEGRLQQKSGSSVQKGVNSQKGKCVRNGDRFQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPLEWAYGSSESPSTSSEGQAGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYVAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSNLMPFQRAG
Protein: Cold sensitive U2 snRNA suppressor 1 (Q02554)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential splicing protein required for U2 snRNP binding to pre-mRNA during spliceosome assembly.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- U2 small nuclear ribonucleoprotein A'
- Small nuclear ribonucleoprotein Sm D3
- Protein HSH49
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor CLF1
- RDS3 complex subunit 10
- U1 small nuclear ribonucleoprotein A
- Pre-mRNA-processing factor 19
- Small nuclear ribonucleoprotein Sm D2
- Pre-mRNA-splicing factor RDS3
Sequence:
MARTKSRKRSGNNQNKNASVVNNKAEIAAMIDARRLEQKKKGGVTNSKGKTNKVVDAKLEKEFKDVLQRFQVQENDTPKEITKDEKNNHVVIVEKNPVMNRKHTAEDELEDTPSDGIEEHLSARKRRKTEKPSLSQLKSQVPYPQIIEWYDCDARYPGLLASIKCTKNVIPVPSHWQSKKEYLSGRSLLGKRPFELPDIIKKTNIEQMRSTLPQSGLDGQDEKSLKEASRARVQPKMGALDLDYKKLHDVFFKIGANWKPDHLLCFGDVYYENRNLFEETNWKRMVDHKRPGRISQELRAIMNLPEGQLPPWCMKMKDIGLPTGYPDLKIAGLNWDITNLKGDVYGKIIPNHHSRSKKQGRNYFGALISFETPEFENSKEDTQANAENGRQDDKIDDEVEHKLDHFQEDISEVTSAEEKLERNEEESEKQLYTVLK
Protein: Beta-lactamase HcpB (EC 3.5.2.6) (Cysteine-rich protein B) (O25103)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
Interaction partners:
- beta-lactamase
- Uncharacterized protein
Sequence:
MVGGGTVKKDLKKAIQYYVKACELNEMFGCLSLVSNSQINKQKLFQYLSKACELNSGNGCRFLGDFYENGKYVKKDLRKAAQYYSKACGLNDQDGCLILGYKQYAGKGVVKNEKQAVKTFEKACRLGSEDACGILNNY
Protein: Exocyst complex component SEC15 (A0A1D8PM29)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Exocyst complex component SEC5
- SNARE-binding exocyst subunit
- Exocyst complex protein EXO70
- Exocyst complex component Sec8
- Exocyst subunit
- Exocyst complex component EXO84
- Ras-related protein SEC4
- GTP-Rho binding exocyst subunit
- Rcy1p
- Rab guanine nucleotide exchange factor SEC2
Sequence:
MPSTQIRNSKTRTSLNGKYSKQVQNKSNGPVVDSLQLENLLLRDEDIFQTTLNSEDYLESLAPIMKDAIKSNGLSELLVKLNEIVKSKDEELNQASMESMDEINTCINTIDNIHKEANELNKQFIQVSSSLNKSAYELMSKKKNYVKYKDVCERINETQVVLNECIQVLELMNKILELIRQTKYFSALKLIDEIINIHIQKVEDFSFAKKIVDSIPHLTKMVKDESFENLCKWLSINLERKLQDIASGLYNNLDELQNNWSKIKKENGPTFLPYKINSPVELALRDPELNYNVFEDVSLQINLNAVYDAVLVYQTLQELDTLSSAYHKEWMSKYSRVIYPITTASVSKKDVVFDNNELYEYLRKIAAFFVTDKQLNLITKFQLRSNTQADELWLSYMTKLKPVLIQLLKHHNFTNIQELGSFKTIVGEFLQIMDNHDYDISELYEVMMMIFKEYYAPLTIQTFRKQFVASIQSDRYRPLTVTDEADYTAIMQNVWYKDDASFAPAYVKSFPVTFPFSEDYVHYCIQVRRLLKDVLRFIGDYYNYEIGELTNTIVNNIIEVVLSDEKGYGIAYEIEEFITRNENNKEITAQTYTNLEYYLFSLYEIGKLVNRELRKHTGMGVHNIDANDTFTLRAVETFNKLKKHAEETVFKMVDNKINELLDMVEYDEYLPVEKNDEANFAIKDFALFLENLFTSIFNNLPSQLRTLGLFRTYDFVSEYFLNVLKDANVYNRIFVANFDLDIQYLETSLRNLHGFKEDGDEANGNGGNVALESTFTELRQCIDLLNLEDYEEFINDSSFRMRRFDRVKYEDGINLIKKMQDNESKQQTSVSAMSERGTIGGVIPNSSSTRSFVNMLSNLSTDDAGNTSSGSIESTSTTSKLAQFTTRFKQNK
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4 (Oligosaccharyl transferase subunit OST4) (Oligosaccharyl transferase 4 kDa subunit) (OTase 4 kDa subunit) (Q99380)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Single-pass type III membrane protein {ECO:0000269|PubMed:29301962}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Protein transport protein SEC61
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1
- Protein transport protein SSS1
Sequence:
MISDEQLNSLAITFGIVMMTLIVIYHAVDSTMSPKN
Protein: Prolyl 3-hydroxylase 2 (C9J313)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYR
Protein: RCC1 domain-containing protein RUG3, mitochondrial (RCC1/UVR8/GEF-like protein 3, mitochondrial) (Q9FJG9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates DNA damage response (DDR) synergistically with ATM. Together with ATM, involved in the splicing of the ND2/NAD2 mRNA. Required for the accumulation of mitochondrial respiratory chain complex I. Negative regulator of plant responses to abscisic acid (ABA). May have a pivotal role in vegetative growth and the phase transition from vegetative to reproductive growth.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21623974, ECO:0000269|PubMed:28262819}.
Interaction partners:
- Transcription termination factor MTERF15, mitochondrial
- Nuclear intron maturase 2, mitochondrial
- Nuclear intron maturase 1, mitochondrial
- Protein WHAT'S THIS FACTOR 9
- Pentatricopeptide repeat-containing protein At1g74900, mitochondrial
- Nuclear intron maturase 4, mitochondrial
- Pentatricopeptide repeat-containing protein At3g48250
- Pentatricopeptide repeat-containing protein At1g51965
- DEAD-box ATP-dependent RNA helicase 53, mitochondrial
- NADH dehydrogenase subunit 2.
Sequence:
MAALSHRLRSFTRRFSSTRTTQRSGGGANTKVPILYTSPDIDSDPVTLQLFSWGRGASGQLGGGIEEIRMYPSPVANLLFRSDQSFSLAQTPGRIDADSSSFRIGISCGLFHSGLTIDGDLWIWGKGDGGRLGFGQENSVFVPNLNPLFEEHSIRCIALGGLHSVALTHQGDVFTWGYGGFGALGHKVYTRELVPRRVDDSWDCKISAIATSGTHTAAITESGELYMWGREEGDGRLGLGPGRGPNEGGGLSVPSKVKALTVPVASVSCGGFFTMALTKEGQLWNWGANSNYELGRGDNLGGWEPMPVPSLEGVRITQIACGGYHSLALTEEGKVLSWGHGGHGQLGSSSLRNQKVPTEIEALADKKIVFIASGGSSSAAITDGGELWMWGNAKDFQLGVPGLPEIQTTPVEVNFLTEEDECQPHKVISISIGASHALCLVSRSP
Protein: Uncharacterized WD repeat-containing protein C1A6.02 (O13856)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Nucleoporin seh1
- Uncharacterized WD repeat-containing protein C4F10.18
- Nucleoporin nup107
- Nucleoporin nup85
- Nucleoporin nup120
- Nucleoporin nup131
- Nucleoporin nup189
- Protein transport protein sec13
- Ribosome biogenesis protein ytm1
Sequence:
MGGTINAAIKQKFENEIFDLACFGENQVLLGFSNGRVSSYQYDVAQISLVEQWSTKRHKKSCRNISVNESGTEFISVGSDGVLKIADTSTGRVSSKWIVDKNKEISPYSVVQWIENDMVFATGDDNGCVSVWDKRTEGGIIHTHNDHIDYISSISPFEERYFVATSGDGVLSVIDARNFKKPILSEEQDEEMTCGAFTRDQHSKKKFAVGTASGVITLFTKGDWGDHTDRILSPIRSHDFSIETITRADSDSLYVGGSDGCIRLLHILPNKYERIIGQHSSRSTVDAVDVTTEGNFLVSCSGTELAFWPVDQKEGDESSSSDNLDSDEDSSSDSEFSSPKKKKKVGNQGKKPLGTDFFDGL
Protein: Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20 (EC 2.7.1.49) (EC 2.7.4.7) (EC 3.5.99.2) (Hydroxymethylpyrimidine kinase) (HMP kinase) (Hydroxymethylpyrimidine phosphate kinase) (HMP-P kinase) (HMP-phosphate kinase) (HMPP kinase) (Q08224)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probably that of HMP to HMP-P.
Interaction partners:
- Thiamine biosynthetic bifunctional enzyme
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5
- Thiamine pyrophosphokinase
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI13
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI11
- Thiamine thiazole synthase
- Constitutive acid phosphatase
- Protein PET18
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI12
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21
Sequence:
MTYSTVSINTPPPYLTLACNEKLPTVLSIAGTDPSGGAGIEADVKTITAHRCYAMTCITALNAQTPVKVYSINNTPKEVVFQTLESNLKDMKCNVIKTGMLTAAAIEVLHEKLLQLGENRPKLVVDPVLVATSGSSLAGKDIVSLITEKVAPFADILTPNIPECYKLLGEERKVNGLQDIFQIAKDLAKITKCSNILVKGGHIPWNDEKEKYITDVLFLGAEQKFIIFKGNFVNTTHTHGTGCTLASAIASNLARGYSLPQSVYGGIEYVQNAVAIGCDVTKETVKDNGPINHVYAVEIPLEKMLSDECFTASDVIPKKPLKSAADKIPGGNFYEYLINHPKVKPHWDSYINHEFVKKVADGTLERKKFQFFIEQDYAYLVDYARVHCIAGSKAPCLEDMEKELVIVGGVRTEMGQHEKRLKEVFGVKDPDYFQKIKRGPALRAYSRYFNDVSRRGNWQELVASLTPCLMGYGEALTKMKGKVTAPEGSVYHEWCETYASSWYREAMDEGEKLLNHILETYPPEQLDTLVTIYAEVCELETNFWTAALEYE
Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (Q9VGD4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
Interaction partners:
- LD14822p
- Cell division cycle 50, isoform A
- Odorant receptor 67d
Sequence:
MIGGRRCSEAARRLRRRPDTLELSVLGGQPIETELQEDNERTPTKGAGNVDEPGIEAPEASCSAPSKRTRWFQFARSSKNRRKRLHCNEDEDVKQPERRNSDLEGSPRACLAQPEGMNIGSSTQTIATPLMIGDSFYSLAPGGGNPPPNKSDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHKLPQDFAFPLGLGTKKTQVLHNNLNSADGPNSKGNNVTGHHMVNNNTNMRHNQNQNHSSMADITADGRGNGGDDGRGSGGSDDMSPRAPCQDLDTINL
Protein: Photoactivated adenylate cyclase subunit alpha-like protein FB (P84737)
Organism: Euglena gracilis
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:16121285}. Note=Paraxonemal body. And paraxonemal bodies (PABs).
Interaction partners:
Sequence:
MYILVWKEGQQIRTFQDLEECGQFQTASNITDGQIFSINVTPTMSKGGETGETQLRRLMYLSASTEPEKCYAEYLADMAHVATLRNKQIGVSGFLLYSSPFFFEVIEGTDEELDFLFAKISADPRHVRCIVLANGPCTGRLYGEWHMKDSHIDNITKHPAIKTILFQIARSFSCMWSYLPKNAANMLLLGKNPNKQAPEPMSVVVTFIYLVEFSSILAHPGQTEQCADILAAFVDACVRNVEGTGAQVAKFITGICIAYWPINRAEDALIGLQQLSEDLAELRSQQRPGSALSLIYSRCGVHYGRALLCNAGFRKADFTLLGDCINTASRITSLSVKLKVPLLLSFEVRCVLGDEMREVLETSGLHKVKGRDQPVQVYQFNARELDSAMVRAKIEQLNPGSYRALCPVKPYESLLPAQRPPIFDDTPRENQPKLSQVQRRDSLVDRLSLIAKLAFPTSMMAGGEGQLITLTYISQAAHPMTRLDLASIQRIAFARNESSNITGSLLHVSGLFVQTLEGPKGAVVSLYLKIRQDKRHKDVVADFMAPSEGREYGSPLDMTSATEEMLTSFPPLQELLTHLAKPFISLETYVPTTVVRYLTAGNNPRNLQPVSVEVVLLATDICSFTPLSEKCSLTEVWTICKTIFVAFIRAIFNEGGEVIKLIGDCVTAYFPPTGADKAVHACQEIVTFCAQLGDAFHDVLDCRSVVACGVGLDFGQVIMAQCGSLGMTEFVVAGEVSARVMEVVALTREAGRAIVITEPLPDRLAPKLRDTGIIPCQEGVDGVPCYGNLGPEWELDVATIKKNIYGFHDARALAAMKKVDVGTNAPGRGAPAGGIPSSPKVRPPGRTNSVSSYTPDPNEALDPPMAESVFLDMCHQRGDTANNSIAVKLRQAANDDRLDLGRMLQGPHELMPVMQAIKHLTNLRMLNMSDNFVVDNNVGELVESCIPMRSLQVLDLSNNPGLTKVIALKRLIKHNTQVREFLLNGTRIAPTEQRKLQSSMNVNRLCASTDLKGSHKYEH
Protein: T-box transcription factor tbx-8 (Q22292)
Organism: Caenorhabditis elegans
Function: Transcription factor (By similarity). Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle. Involved in regulating expression of vab-7. Appears to have partially redundant function to tbx-9.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:15066124, ECO:0000269|PubMed:15102704}.
Interaction partners:
- Homeobox protein vab-7
- C2H2-type domain-containing protein
- Zinc finger protein ztf-2
- Homeobox protein nob-1
- Homeobox protein pal-1
- Serum response factor homolog
- Hand transcription factor 1
- Nuclear hormone receptor family member nhr-25
- Transcription factor elt-1
- Grainyhead-like protein 1 homolog
Sequence:
MTDQVYVTLREDQDKLWNLFHYHKNEMIVTKSGRKMFPKLEYVVRGLTPNKLYAMMLHIEPSDDHRYKFSSGEWVKSGKAEKHREPKKLWHADGVRSGKEWMTNPVCFDRVKITNCAESTNASMIFLHSMHKYTPVMSIYESPSESPFSVPQPSTRLVTSVRLTYTEFIAVTAYQNDAVIKLKIKFNPFAKGFREGSQSDRKRNSPSADDSTTDESSSQVSSPQPKKSRTVSVSPPLMPRILPTMIPPPPAINPLFYSLPYFSHLAATGNFPPVPFQFPFGLPCFSPMSFPTPPPSLKNVKKEEQEDIEQEINVV
Protein: CheC-like family protein (O51614)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
- CheY
- Purine-binding chemotaxis protein
- CheY
- Chemotaxis response regulator
- Chemotaxis protein CheA
- RNA-binding protein KhpB N-terminal domain-containing protein
- DNA polymerase I
Sequence:
MRIDYIEPFLDAASSVLRDMLLVENIEMGKPGLKSINQKIKGVSVIVGLAGSVEGSIIIDMDIETALFVASKLNFEEYDDFDDEETKEMVAATLTEVGNIIAGNFVTTLHAKGFVFDITPPAFIYGENMKISNKGSEALIVPFSLPDGKIIEVNIAIRERV
Protein: Enhancer of zeste 2 polycomb repressive complex 2 subunit (A0A8I6A8A9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTREAIHLLSLYDFP
Protein: LMBR1 domain containing 1 (A0A494C126)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XIVLHTSYMIYSLAPQYVMYGSQNYLIETNITSDNHKGNSTLSVPKRCDADAPEDQCTVTRTYLFLHKFWFFSAAYYFGNWAFLGVFLIGLIVSCCKGKKSVIEGVDEDSDISDDEPSVYSA
Protein: TPM domain-containing protein (Q9XXJ4)
Organism: Caenorhabditis elegans
Interaction partners:
- G-protein coupled receptors family 1 profile domain-containing protein
- EF-hand domain-containing protein
- Neurotransmitter-gated ion-channel ligand-binding domain-containing protein
- Serpentine Receptor, class Z
- G-protein coupled receptors family 1 profile domain-containing protein
- Neurotransmitter-gated ion-channel ligand-binding domain-containing protein
- EF-hand domain-containing protein
- Serpentine receptor class r-10
- Serpentine receptor class r-10
- Dipeptidyl peptidase family member 6
Sequence:
MLRAIILSLATVFVLCTESDYTVETYPNPKRGGYKECGLRSSGLVCDPYETLSESERYRINNQLINFVTKTEEGGNTFCSKKGTDAMFVIMNKASQEFADNLRKHWSTIDTQCGRFGLLVLSLDDRQIFGSFDERSPINMAQLQAIIATEENHIKTGAYTTAVTNILKEVAASMTPQKGVTTTTPASSTKYSPAQLSVCSFLAALLYFF
Protein: Ubiquitin-like modifier-activating enzyme atg7 (ATG12-activating enzyme E1 atg7) (Autophagy-related protein 7) (O43069)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity). Plays a role in meiosis and sporulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Autophagy-related protein 8
- Autophagy-related protein 3
- Ubiquitin-like protein ATG12
- Putative lipase atg15
- Autophagy protein 5
- Probable cysteine protease atg4
- Autophagy-related protein 9
- Serine/threonine-protein kinase atg1
- Vacuolar protein sorting-associated protein atg6
- Autophagy-related protein 101
Sequence:
MFVGKALQFQSFHSSIDATFWHQLSNYKVEKQKLDASPLTIHGKFNTYSRGNISIVFGEAPSNSNIKDCLAEGTLLNANTPQEFTNADVKKIREEIGEVLLNSIKNGVVSERPNELLRFLIFSYADIKAYKYHYWCLFPSFKETPHWIVKDLSPAESLIPSGPILSQIREFLSTADYYQRPFFLLIKSTLDEWTIAPLKELSHCVDKSLQFYLVAEDSVQLAEYPSWPVRNILAFAFIKFKLKVINLFLYRDGINSDTLSKSILIKVEADKDMILEAPLSIVGWERNGKGVLGPRVVNLSTVLDPFVLSESASTLNLSLMRWRLVPQLDLDRIQNSKCLLLGAGTLGCGVARNLLSWGVRHVTFVDYSTVSYSNPVRQSLFTFEDCKRKLPKAECAAQRLKEIYPNMFSTGYNISIPMLGHPIYEAGIEKTMHDYETLENLISTHDAIFLLTDTRESRWLPTVISTAMDKLLINSALGFDSWLVMRHGSVLQKENRLGCYFCNDIFAPSNSLVDRTLDQTCTVTRSGCANIATAIAVELFVSLLQHPNGHAAPVLNEDQTVLGELPHQIRGFLHNFSLMKISGMAYPQCSACSECIINEWNREKWMFVLRAINEPDYVEELCGLREVQALGEIAGTMEEWISDKESVIL
Protein: Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase) (P08524)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Farnesyl pyrophosphate synthase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Interaction partners:
- Diphosphomevalonate decarboxylase
- Isopentenyl-diphosphate delta-isomerase
- Squalene synthase ERG9
- Geranylgeranyl pyrophosphate synthase BTS1
- Dehydrodolichyl diphosphate synthase complex subunit RER2
- Dehydrodolichyl diphosphate synthase complex subunit SRT1-farnesyl diphosphate specific))
- Hexaprenyl pyrophosphate synthase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase
- Mevalonate kinase
- Phosphomevalonate kinase
Sequence:
MASEKEIRRERFLNVFPKLVEELNASLLAYGMPKEACDWYAHSLNYNTPGGKLNRGLSVVDTYAILSNKTVEQLGQEEYEKVAILGWCIELLQAYFLVADDMMDKSITRRGQPCWYKVPEVGEIAINDAFMLEAAIYKLLKSHFRNEKYYIDITELFHEVTFQTELGQLMDLITAPEDKVDLSKFSLKKHSFIVTFKTAYYSFYLPVALAMYVAGITDEKDLKQARDVLIPLGEYFQIQDDYLDCFGTPEQIGKIGTDIQDNKCSWVINKALELASAEQRKTLDENYGKKDSVAEAKCKKIFNDLKIEQLYHEYEESIAKDLKAKISQVDESRGFKADVLTAFLNKVYKRSK