Protein: Chromosome condensation protein dpy-27 (Protein dumpy-27) (P48996)
Organism: Caenorhabditis elegans
Function: Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase. Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome. Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on dosage compensated X chromosomes. As a member of the dosage compensation complex, also binds to regulatory regions of the autosomal her-1 gene, required for male development, possibly contributing to its repression in hermaphrodites. Also plays a role in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:14660541, ECO:0000269|PubMed:19119011, ECO:0000269|PubMed:23028348, ECO:0000269|PubMed:7954812, ECO:0000269|PubMed:8939870}. Chromosome {ECO:0000269|PubMed:19119011, ECO:0000269|PubMed:23028348, ECO:0000269|PubMed:7954812, ECO:0000269|PubMed:8939870}. Note=In interphase cells, diffusely distributed in nuclei before the onset of dosage compensation (PubMed:19119011). Associates with chromatin after the 30-cell stage when dosage compensation is initiated (PubMed:19119011, PubMed:23028348, PubMed:7954812). Specifically localizes to the X chromosomes of hermaphrodite (XX) embryos, but remains diffusely distributed throughout the nuclei of male (XO) embryos (PubMed:23028348, PubMed:7954812). dpy-26 is required for its X chromosome specific association (PubMed:8939870). {ECO:0000269|PubMed:14660541, ECO:0000269|PubMed:19119011, ECO:0000269|PubMed:23028348, ECO:0000269|PubMed:7954812, ECO:0000269|PubMed:8939870}.
Interaction partners:
- Condensin complex subunit dpy-26
- Condensin complex subunit 1
- Mitotic chromosome and X-chromosome-associated protein mix-1
- Condensin complex subunit capg-1
- Uncharacterized protein C30G12.6
- Lysine-specific demethylase 9
- Condensin-2 complex subunit kle-2
- Zinc finger protein sdc-3
- Condensin-2 complex subunit hcp-6
- CAP-G condensin subunit
Sequence:
MQPFKRRALTSDDDRPYADTDSMPEVDLDVDRRRQYMEQLNIFDDVSSGAYMLELEAAENGVKYDEKEDLLNVQIPPKYEDQISDPDGNRMIILNIYVENFKSYAGKHILGPFHKNLTMILGPNGSGKSNVIDALLFVFGFKAGKIRTKKLSALINSGGNYESCSVTIMFQMVKDMPVENYDKYEVLTDNCVCITRTINRENNSKYRIDDKDASQKDVQELLLRAGIDMTHNRFLILQGEVEAIALMKPTSKNPNEEGMLEYIEDIVGTNRFVAPISKLMHRVSLLEHKSSQYGASVRRHEGHLKVFEKAMVIGMAYLNTFNNLNYLRGIRVKHNLCRYAETMRDAKMSLVTRTGELEENKDIMLEAKDEVRKKETHERSLNSIVTELENKRIDWQSKKNDWHARDAKRKQGLKSCTQDLGKLMKERDEARREKFEIETAPENARISKQNMQLEWDQLKEQENVCQRTATENLIKYDQKSSADRAKHDDLEKKLSDELLQSMRAKAELDVSESELKDMTIMMEQGQKRVDELKGTLQTMMAENIRDNTELNAVTTELQDRKLKFDKAVEKLPHLKSTEQLLRSKKYELDQEVIEASNTQEVTYRHQATAKLHELKEAGLFPGFKGRLGDLASIPIKFDTAISTVFFAQLDYHVVQTSDECRIGIGFCHEYKLPRTTFVFLDHLKDTDTSGMDSTMKFPAERLFDKIHCVNPEIRREFYFLIHDILVVDSLEEATRIDKKYPGRHRYCTLNGSILNRSGALTGGGKPTTGRIRNDNNPNMSGVKKVDLSKLRAAQEKHNHALEAHLKLQLKQEEIRADNGPIIKQLEIRKRELIMSTKEQKTRIAELKSSIAAHERRMVNYREVTVEDLDEKRAQIADLKRQVEESQKSSAKIKQQIEQYKRKMDRMFMELVQKNKDSIEQAKDRMGQLEQDIARQTAIIENNPSHLEQAEKKLSELEHMCLEKRSEADALAQLEVGEDVKGIDIINAQLQTSTASIDAQRARYTEAVAARREADAAYQTTVDNYNMVKQTYDELMRIIDDLENKTMADNAELDIIESAWMQPEKLYPPGKFVRYNDPDIAAKMTDGHVVLPYECISMIEPHREAYEEHEARMLEDDVFEDTANKICKLEKDVDKFRREFDNKGVRDYAMIVSLLMNEVTSAKKFSDKLKAHREKLNELRMARFNEFSEALAFLGTTTQMLYQLITNGGDASLKFVEEGKSTDPFDGGIKFSVRPAKKSWKLIENLSGGEKTLASLCFVFAMHHYRPTPLYVMDEIDAALDLNNVSLIANYIKHSERTRNAQFIIISLRNQMFEVGNRLLGIYKIDGKTYNIMVDPIAVEIKNRPILKIFEEEIKRREKLRRAEIEPEIDLSNGLSNVVIAPKRKQRRLEMLKLSDFGLDDDSDLPEFNRFPPATRRELSVEDSDEDDEPVRRRPRRQVEEEDEEDELIEEATPSPPPIVVQRRVRRSRH