wanglab/gogpt-training-data huggingface dataset:
Protein: DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) (Q9UPW6)
Organism: Homo sapiens (Human)
Function: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
Subcellular location: Nucleus matrix {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374, ECO:0000269|PubMed:14701874}.
Interaction partners:
- T-box brain protein 1
- Runt-related transcription factor 2
- B-cell lymphoma/leukemia 11B
- DNA-binding protein SATB1
- Homeobox protein cut-like 1
- Fez family zinc finger protein 2
- Histone deacetylase 1
- Forkhead box protein G1
- Paired box protein Pax-6
- Forkhead box P1
Sequence:
MERRSESPCLRDSPDRRSGSPDVKGPPPVKVARLEQNGSPMGARGRPNGAVAKAVGGLMIPVFCVVEQLDGSLEYDNREEHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAPDATVADMLQDVYHVVTLKIQLQSCSKLEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIKVERVERENLSDYCVLGQRPMHLPNMNQLASLGKTNEQSPHSQIHHSTPIRNQVPALQPIMSPGLLSPQLSPQLVRQQIAMAHLINQQIAVSRLLAHQHPQAINQQFLNHPPIPRAVKPEPTNSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKEEDPRTASQSLLVNLRAMQNFLNLPEVERDRIYQDERERSMNPNVSMVSSASSSPSSSRTPQAKTSTPTTDLPIKVDGANINITAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRWKENPSPENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREEAPPPPPPTEDSCAKKPRSRTKISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEEMYKVEAEEENADKSKAAPAEIDQR
Protein: C2H2-type domain-containing protein (Q384I6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRVGGYMGTSEEDGNTELSVNGSLDGEKSMGFRCLKCVGEISTWTKLTKHLDTSWHYSAACVECGKKHSYFGSSQPHRHEMSTKHRGFLGIFHERNDYKIDHPMVLTRDQYRCHCGTSFLCVLHLAIHLRDEHHNQYIPKTVKCLTCQEEGMLDEMAEHWTTKKSENRKGRGLRSKRGTGPCDEGGVPKDCEFEVEGFGVDQFLVPFPKRPPRSPNGSQYVILYQCPTCRLLFDEWADIRQHIEESNHVHGLPPALLRRRIERRVGLIEQGSTGYGQVDYRTAGNRSAVRYLKELLEVFADINNPAVRELLYRYAPTNKNVDPDDEEVFGYQCPLEECSQAFLTYGEFRSHMKSTKHQTECNIDPVTGKPWLPSWESNPYAFEVTFTMRQLVEVFGYRKCGECNRPYRPGEEHYHYQMHHFTEKIDFRILESTL
Protein: Putative holocytochrome-c1 synthase (EC 4.4.1.17) (Cytochrome c1 heme lyase) (CC1HL) (O13962)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C1 apoprotein to produce the mature functional cytochrome.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q00873}.
Interaction partners:
- Protoheme IX farnesyltransferase, mitochondrial
- Putative holocytochrome-c synthase
- Ferrochelatase, mitochondrial
- Uncharacterized FAD-binding protein C17H9.12c
- Cytochrome c1, heme protein, mitochondrial
- Probable mannosyl-oligosaccharide glucosidase
- RNA exonuclease 4
- Glutamate/glycine mitochondrial carrier ymc1
Sequence:
MQPEQLNQEEESKCPVPPEVRDAWLKSHGGKKPSEVHDTPHPTMLPTEREISTIPKVVTESDSGKEEKWIYPSQQMFFDAMKRKNWNPHPEDMKTIVPIHNAVNERAWQDILQWEQGWGSEKCGGPKLERFDGNVKKLTPKARILNLLGYNKPFDRHDWLVNRCGRKVAYVIDFYNGPTVNGTPSIYLDVRPKLSVHGAWMRVYRWTNEHFSQNSK
Protein: Ca2+-channel-protein-beta-subunit, isoform L (M9PD84)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Voltage-dependent calcium channel type D subunit alpha-1
- Voltage-dependent calcium channel type A subunit alpha-1
- Straightjacket, isoform C
- Stolid, isoform H
- Ca[2+] channel Muscle-specific alpha2/delta subunit, isoform A
- GH12419p1
- Sodium channel protein 60E
- Ca[2+]-channel protein alpha[[1]] subunit T, isoform F
- Sodium leak channel NALCN
- Rab3 interacting molecule, isoform F
Sequence:
MVQRASSSDAPSVQGGQHRESRFGLGYPSYQSGYNKLFTQGSADSNYSQPSSDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDNIRMQNQTRPSRLYGTKGSSSGNLGAGGQAGAEPSRGSTPPTPGDESDSMGPGRHGKTPAAAANKEKRKPFFKKQETASPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKRAIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKVLQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATHPDIRAVPPIARPLPQEASPSADPARLGPTPPVDGEEFVDEQDPRMGMSGGDREGSRERDRDSRERERERERERDYWDREFNRDRSSKDRERDLEWERERAREWERERERDWDREFDWDQGGTSYQHSRRQPTSVRHQERGGGVGAGGGGGGVGGGYERDRERERYERRERDLMHYDLNSDELLDERNFEYPAMRSGPSGASHHGHLSRGGRLLEDPDFEREEAQMRMSSSRYGPSTRIDDPRDLPRGATVVDRDEYSPHRGGGSSRRMLNAMSRPLGLPRQSSLPSNRAPVSYLPRQSSLGTHWLSSSSQSNLDQGPQSRRELYPLLHQPQSYSQPRSQYTSHSYTSAPQHTSQSRSQSQSHSQSHSQYRYSVQDTSFAHPPRSLREEFLSPTMSKVEAVTHAIRNKIIVEEDEEDILSTDRFY
Protein: Casein kinase I homolog hhp1 (EC 2.7.11.1) (P40235)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in DNA repair. Has a probable role in repairing alkylated DNA and may regulate the activity of protein(s) involved in double strand break repair caused by gamma rays.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Casein kinase I homolog hhp2
- Protein LTV1
- Spindle pole body protein ppc89
- Uncharacterized protein C13G1.09
- Serine/threonine-protein kinase rio2
- Ribosome biogenesis protein tsr1
- 20S-pre-rRNA D-site endonuclease nob1
- Small ribosomal subunit protein uS3
- Pre-rRNA-processing protein pno1
- Small ribosomal subunit protein uS5
Sequence:
MALDLRIGNKYRIGRKIGSGSFGDIYLGTNVVSGEEVAIKLESTRAKHPQLEYEYRVYRILSGGVGIPFVRWFGVECDYNAMVMDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEFIHSKSFLHRDIKPDNFLMGIGKRGNQVNIIDFGLAKKYRDHKTHLHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLVYFCRGSLPWQGLKATTKKQKYEKIMEKKISTPTEVLCRGFPQEFSIYLNYTRSLRFDDKPDYAYLRKLFRDLFCRQSYEFDYMFDWTLKRKTQQDQQHQQQLQQQLSATPQAINPPPERSSFRNYQKQNFDEKGGDINTTVPVINDPSATGAQYINRPN
Protein: COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3) (P10589)
Organism: Homo sapiens (Human)
Function: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- B-cell lymphoma/leukemia 11B
- Nuclear receptor corepressor 1
- BCL11 transcription factor A
- Estrogen receptor
- Insulin gene enhancer protein ISL-1
- Transcription initiation factor IIB
Sequence:
MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS
Protein: Maintenance of telomere capping protein 6 (P38849)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in telomere capping.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Defect at low temperature protein 1
- Maintenance of telomere capping protein 4
- Putative uncharacterized protein YDL172C
- Maintenance of telomere capping protein 2
- Protein CSF1
- Ergosteryl-beta-glucosidase
Sequence:
MWILIYLFIIWSSLRTWVTAVDSTTTVGDDLNETVSASVWPTMSPQMTVAFRSQRDVMGNLTIDQLPYVGLNLRRVLLNNETSMVNEGNNTRLLTLFKSMLSSEANAFVLDLEQYNNDLRVVDTTLLFSDVLTALQSFIFSTQNNLYANIIVLLLNISAPELDSTEYRHQNQTLNTTYILDKNLGNSFIYKPTDLQSDRAKNNTWNIYGKSSIDGWPTLGSVLYEQKKRLVIGELTDFFNETTAPYIFPHDVFHYEQGNSTLDCPSTVEGLTDLSSIHWRFLDSLFNSVDIKEYISCGLSPIISNSAYVNNVTQLADIIHEGSVWSWDSDQPSVTQSTSKSGSSSGTLEAYNCVLLYYFANNETVTWRVGNCYNSNIGLCRYENMAFRWLVRSNKATYFDFDSYQGSKCPDQYSFNIPRSPLEQRSFIAYMRNSSFSDTQIWIDLNSISVSNCWVSGGPYASCPYEKVISRRNFVTMMVPASVCSFALLCIVVYLSVLRVPIYDNRKNWRRVINKISKSELEGVPS
Protein: Propanediol dehydratase-reactivating factor small subunit (DDR small subunit) (Propanediol utilization protein PduH) (Q8ZNR6)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Small subunit of the propanediol dehydratase-reactivating factor (DDR), which reactivates suicidally inhibited adenosylcobalamin-dependent propanediol dehydratase (diol dehydratase, DDH) found in the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. Reactivates inactivated DDH in the presence of ATP, Mg(2+) and free adenosylcobalamin (AdoCbl), by mediating the exchange of the tightly bound damaged cofactor AdoCbl for a free intact one.
Subcellular location: Bacterial microcompartment {ECO:0000269|PubMed:12923081}.
Interaction partners:
- Propanediol dehydratase-reactivating factor large subunit
- Propanediol dehydratase small subunit
- Propanediol dehydratase medium subunit
- Propanediol dehydratase large subunit
- Bacterial microcompartment shell protein PduB
- Bacterial microcompartment shell vertex protein PduN
- Propanal dehydrogenase
- Corrinoid adenosyltransferase PduO
- Bacterial microcompartment shell protein PduK
- Bacterial microcompartment assembly protein PduM
Sequence:
MDSNHSAPAIVITVINDCASLWHEVLLGIEEEGIPFLLQHHPAGDIVDSAWQAARSSPLLVGIACDRHSLVVHYKNLPASAPLFTLMHHQDSQAQRNTGNNAARLVKGIPFRDLHA
Protein: Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14) (P02533)
Organism: Homo sapiens (Human)
Function: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11724817, ECO:0000269|PubMed:31995743, ECO:0000269|PubMed:32179842}. Nucleus {ECO:0000269|PubMed:11724817}. Note=Expressed in both as a filamentous pattern. {ECO:0000269|PubMed:11724817}.
Interaction partners:
- Keratin, type II cytoskeletal 5
- Keratin, type I cytoskeletal 16
- Plectin
- Collagen alpha-1
- Keratin, type II cytoskeletal 6B
- Keratin, type I cytoskeletal 17
- Tumor protein 63
- Loricrin
- Desmoglein-3
- Plakophilin-1
Sequence:
MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSSRFSSGGACGLGGGYGGGFSSSSSSFGSGFGGGYGGGLGAGLGGGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTIEDLRNKILTATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSGSQSSRDVTSSSRQIRTKVMDVHDGKVVSTHEQVLRTKN
Protein: Fibrinogen silencer binding protein (F1LYB7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- DNA repair and recombination protein RAD54-like
- Breast cancer type 1 susceptibility protein homolog
- DNA repair protein RAD51 homolog
- DNA repair protein RAD52 homolog
- Transcriptional regulator ATRX
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- RAD51 paralog B
- DNA repair protein
- RNA helicase
Sequence:
MRRSAAPSQVRGNSSKKARFVPPGRSTTGVSKEISMSPEAKLVQGAHQSQGDAGVCSSNPWLTEGSPVEMGDGARVDPLSPVHLASKEIIESKAQEEEASSLLKYFSVVWCKASKKKHKKWEGDAILIVKGRSFILKDMEGKDIGRGIGYKFKELENVEEGQTLMLGGKEIEILGTVSAEDFNSGKCFQAGSGSPAVPSSQAARKCFSNPFKSVCQSTQARRDRGNDWQNCKPRYDPYTPNALVMPRPDKSHQWAFNRSCLPTVDVVIDPHLVRHLRPHQKDGVAFLYECVMGMRAVGKCGAILADEMGLGKTLQCISLIWTLQCQGPYGGKPIVKRTLIVTPGSLVNNWRKEFQKWLGSERIKIFTVDQDHKVEEFINSAFHSVLIISYEMLLRSLDRIKTITFGLLICDEGHRLKNSGIKTTAALSSLSCEKRVILTGTPVQNDLQEFFALVDFVNPGILGSLSSYRRIYEEPIVMSREPSASKEERELGERRTTELTRLTGCFILRRTQEVINKYLPPKIENVVFCRPGALQIELYRKLLSSQSVRFCLQGLLGNSAHLICIGALKKLCNHPRLLFSFVKGKEFNSSRDENEERSLCQGLLTVFPAGYNLLQLSESESGKLQVLVKLLAAISELRPTEKVILVSNYRQTLNLLEEVCKCHGYACARLDGQTPVSQRQQIVDNFNSKYSTDFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMARVWRDGQKHPVHVYRLLTTGTIEEKIYQRQISKQGLSGAVVDLTRSSEQIQFSVEELKNLFTLHENSHCVTHDLLDCECTGEKDHSDDASENPVTSRQCQLGPQKSSSSRPLSMSQLKQWKHFSGDHLNLPDPFLERIRENVSFFFQNITNQAPAI
Protein: Tubulin beta chain (B1PBW6)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MREILHIQGGQCGNQIGAKFWEVVCAEHGIDSTGKYHGDSDLQLERINVYYNEASCGRYVPRAVLMDLEPGTMDGVRSGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMLNVQNKNSSYFVEWIPNNVKSTVCDIPPNGLKMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADDEEEYEEEEEEYQD
Protein: Complex I assembly factor TIMMDC1, mitochondrial (Translocase of inner mitochondrial membrane domain-containing protein 1) (C9JU35)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEVPPPAPRSFLCRALCLFPRVFAAEAVTADSEVLEERQKRLPYVPEPYYPESGWDRLRELFGKDTPVGGLLMAFQKYSGETVQERKQKDRKALHELKLEEWKGRLQVTEHLPEKIESSLQEDEPENDAKKIEALLNLPRNPSVIDKQDKD
Protein: Iron-sulfur cluster assembly SufBD family protein Rv1462 (P9WFP5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible nitrogen fixation related protein
- Probable conserved ATP-binding protein ABC transporter
- Probable cysteine desulfurase
- Conserved protein
- Iron-sulfur cluster assembly SufBD family protein Rv1461
- Probable hercynylcysteine sulfoxide lyase
- Probable transcriptional regulatory protein
- Uncharacterized protein Rv3778c
- Alpha-
- Probable unidentified antibiotic-transport integral membrane ABC transporter
Sequence:
MTAPGLTAAVEGIAHNKGELFASFDVDAFEVPHGRDEIWRFTPLRRLRGLHDGSARATGSATITVSERPGVYTQTVRRGDPRLGEGGVPTDRVAAQAFSSFNSATLVTVERDTQVVEPVGITVTGPGEGAVAYGHLQVRIEELGEAVVVIDHRGGGTYADNVEFVVDDAARLTAVWIADWADNTVHLSAHHARIGKDAVLRHVTVMLGGDVVRMSAGVRFCGAGGDAELLGLYFADDGQHLESRLLVDHAHPDCKSNVLYKGALQGDPASSLPDAHTVWVGDVLIRAQATGTDTFEVNRNLVLTDGARADSVPNLEIETGEIVGAGHASATGRFDDEQLFYLRSRGIPEAQARRLVVRGFFGEIIAKIAVPEVRERLTAAIEHELEITESTEKTTVS
Protein: U-box domain-containing protein 32 (EC 2.3.2.27) (Plant U-box protein 32) (RING-type E3 ubiquitin transferase PUB32) (Q94A51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as an E3 ubiquitin ligase.
Interaction partners:
- Probable elongation factor 1-gamma 2
- Large ribosomal subunit protein uL18y
- Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta 2
- Fructose-bisphosphate aldolase 5, cytosolic
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS1z
- Elongation factor 1-delta, putative
- Elongation factor 1-delta 1
- Elongation factor 1-delta 2
- Elongation factor 1-beta 2
Sequence:
MGEIGGEELVLDVDETIFVAVAEDVERSKTTVLWAARNFSGKKICLLYVHRTARAASWTHKKLVGGSFKKHDVKVIERVEKPKVDELMNSYLQLLSETEIQTDKLCIAGQNIEECIVELIARHKIKWLVMGAASDKHYSWKMTDLKSKKAIFVCKKAPDSCHIWFLCKGYLIFTRASNDDSNNRQTMPPLVQLDSDNETRKSEKLESSYMRRRLRYWRSLLEQDGEKDTGQLEREKVEPRAPPLFSSGSSSSFGEPVGPEPVSPELVDSDTLNTSNVEEKEREGDVARKVHRYDKAMHDIGQSDRTVYGEAGKKWEEDASTTEALCKAKALEGLCIKESSQRKRLEELLEKEKLEVKMVIEQNNGFMKELQMVQGRNLKLESQMRKLQDLEKEHGEKFDTAMELLKSFRQKRDEIRIDHENAVKEVNALRRLVKGETGESSGSEMLDYSFMEINEATNEFDPSWKLGEGKYGSVYKGNLQHLQVAVKMLPSYGSLNHFEFERRVEILSRVRHPNLVTLMGACPESRSLIYQYIPNGSLEDCFSSENNVPALSWESRIRIASEICSALLFLHSNIPCIIHGNLKPSKILLDSNLVTKINDYGISQLIPIDGLDKSDPHVDPHYFVSREMTLESDIYAFGIILLQLLTRRPVSGILRDVKCALENDNISAVLDNSAGDWPVARGKKLANVAIRCCKKNPMNRPDLAVVLRFIDRMKAPEVPSSETSSYANQNVPRRPPSHYLCPIFQEVMKDPLIAADGFTYEAEAIREWLANGHDTSPMTNLKMEDCNLIPNHALHLAIQDWQNQW
Protein: Multiphosphoryl transfer protein 1 (MTP 1) (Triphosphoryl transfer protein 1) (TTP 1) [Includes: Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (Phosphotransferase system enzyme I); Phosphocarrier protein HPr (Protein H); PTS system fructose-like EIIA component (EC 2.7.1.202) (Fructose-like phosphotransferase enzyme IIA component)] (P77439)
Organism: Escherichia coli (strain K12)
Function: Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Multiphosphoryl transfer protein
- PTS system glucose-specific EIIA component
- PTS system N-acetylglucosamine-specific EIICBA component
- PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM
- Multiphosphoryl transfer protein 2
- PTS system beta-glucoside-specific EIIBCA component
- Phosphocarrier protein HPr
- PTS system 2-O-alpha-mannosyl-D-glycerate-specific EIIABC component
- 1-phosphofructokinase
- ATP-dependent 6-phosphofructokinase isozyme 2
Sequence:
MLTIQFLCPLPNGLHARPAWELKEQCSQWQSEITFINHRQNAKADAKSSLALIGTGTLFNDSCSLNISGSDEEQARRVLEEYIQVRFIDSDSVQPTQAELTAHPLPRSLSRLNPDLLYGNVLASGVGVGTLTLLQSDSLDSYRAIPASAQDSTRLEHSLATLAEQLNQQLRERDGESKTILSAHLSLIQDDEFAGNIRRLMTEQHQGLGAAIISNMEQVCAKLSASASDYLRERVSDIRDISEQLLHITWPELKPRNKLVLEKPTILVAEDLTPSQFLSLDLKNLAGMILEKTGRTSHTLILARASAIPVLSGLPLDAIARYAGQPAVLDAQCGVLAINPNDAVSGYYQVAQTLADKRQKQQAQAAAQLAYSRDNKRIDIAANIGTALEAPGAFANGAEGVGLFRTEMLYMDRDSAPDEQEQFEAYQQVLLAAGDKPIIFRTMDIGGDKSIPYLNIPQEENPFLGYRAVRIYPEFAGLFRTQLRAILRAASFGNAQLMIPMVHSLDQILWVKGEIQKAIVELKRDGLRHAETITLGIMVEVPSVCYIIDHFCDEVDFFSIGSNDMTQYLYAVDRNNPRVSPLYNPITPSFLRMLQQIVTTAHQRGKWVGICGELGGESRYLPLLLGLGLDELSMSSPRIPAVKSQLRQLDSEACRELARQACECRSAQEIEALLTAFTPEEDVRPLLALENIFVDQDFSNKEQAIQFLCGNLGVNGRTEHPFELEEDVWQREEIVTTGVGFGVAIPHTKSQWIRHSSISIARLAKPIGWQSEMGEVELVIMLTLGANEGMNHVKVFSQLARKLVNKNFRQSLFAAQDAQSILTLLETELTF
Protein: Kruppel-like factor 1 (Q9TZ64)
Organism: Caenorhabditis elegans
Function: Transcription factor which modulates genes involved in lipid metabolism and the phase I detoxification pathway, including cytochrome P450 oxidases. Required for diet restriction- and mitochondrial dysfunction-mediated lifespan extension, perhaps acting in a ubiquitination-dependent manner. Involved in the response to oxidative stress. Plays a role in cell death.
Subcellular location: Nucleus {ECO:0000269|PubMed:31346165}. Cytoplasm {ECO:0000269|PubMed:31346165}. Note=Localized to nucleus at the larval L4 stage, becoming cytoplasmic during early adulthood. Translocation to the nucleus dependent, in some circumstances, on oxidative stress. {ECO:0000269|PubMed:31346165}.
Interaction partners:
- AAA+ ATPase domain-containing protein
- E3 ubiquitin-protein ligase wwp-1
- CYtochrome P450 family
Sequence:
MTSSSINATSSREPLIHIPNKPSLSIDPLARADRSVHLSPSFFQPGLSSISSENDDAEQRIHEATRSFNQFGHQFYESIRELSESTSAYERLKANALRRKLENTFGNDSGAATSSSSSSVFERQSDFSAFAPYKNSHFDSTQSLFQPTTSFNDRLEQIKSDFIAEHQKSMSSFSGFNTPTTALGAAFQGMQVKKSAFAPVLLRENLDTRRPGGHLISDILNRDPLPQSRNLNLNMARNVPIRLIHSTSNFDIASSSSGDSGHQDHESIVVEDADMDSPTSPCVKRSAMNFDLRDEPLTVNVESVSSTSDLPSSVSSSVNSFVYQNFDPLEFKRKIDELTASACLAVMPDANGQVDPMAIKTQLDAIKKQMEEHQTHMAEASQRLHVDSSLEDSNCEPSPSSSYDASEPSVKRLHHCTHPNCGKVYTKSSHLKAHFRTHTGEKPYECSWDGCDWRFARSDELTRHYRKHTGDRPFKCSQCSRAFSRSDHLSLHMKRHF
Protein: AGAMOUS-like 89 (At5g27580) (MADS-box family protein) (MADS-box protein AGL89) (Q7XJL1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Tropinone reductase homolog At2g29320
- Tropinone reductase homolog At5g06060
- Tropinone reductase homolog At2g29150
- Tropinone reductase homolog At1g07450
- Tropinone reductase homolog At2g29340
- Tropinone reductase homolog At1g07440
- Tropinone reductase homolog At2g29310
- Tropinone reductase homolog At2g29370
- Tropinone reductase homolog At2g29360
- Tropinone reductase homolog At2g29260, chloroplastic
Sequence:
MDSSMSTKKKTKLSVRNQTCFKKSSLSSSSTAKKTTNLSMREETMFKKALELSTLCDIEVCVIYYGRDGELIKTWPEDQSKVRDMAERFSKLHERERRKKRTNLSLFLRKKILDDNKLSEKVLEMKDSLESGLRVLQDKLLLLQPENQTELGQSRAVSSTTNPLSSPEDHHHQQWTEPLVTGVSNTEQDLSTSPLSNHQSKYSVFVYNHDSGSFYQVPDSICF
Protein: Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) (P28290)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14673706}. Note=Located near the plasma membrane. Associated with actin filaments. May also exist as a membrane-bound form with extracellular regions.
Interaction partners:
- Protein cordon-bleu
Sequence:
MDRPLSSSAEAEEELEWQVASRRRKAWAKCRSSWQASETEDLSTEATTQDEEEDEEEDLPGAQLPAAGGRGNVPNEKIAIWLKDCRTPLGASLDEQSSSTLKGVLVRNGGSFEDDLSLGAEANHLHESDAQIENCNNILAKERRLQFHQKGRSMNSTGSGKSSGTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKVFLSAQMQRMEVENPNYALTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSMSSVTSNKETDPPPPLTRSNTANRLMKTLSKLNLCVDKTEKGESSSPSPSAEKGKILNVSVIEESGNKNDQKSQKIMKKKESSSMLATVKEEVSGSSAAVTENADSDRISDEANSNFNQGTENEQSKETQSHESKLGEESGIVESKLDSDFNISSHSELENSSELKSVHISTPEKEPCAPLTIPSIRNIMTQQKDSFEMEEVQSTEGEAPHVPATYQLGLTKSKRDHLLRTASQHSDSSGFAEDSTDCLSLNHLQVQESLQAMGSSADSCDSETTVTSLGEDLATPTAQDQPYFNESEEESLVPLQKGLEKAAAVADKRKSGSQDFPQCNTIENTGTKQSTCSPGDHIIEITEVEEDLFPAETVELLREASAESDVGKSSESEFTQYTTHHILKSLASIEAKCSDMSSENTTGPPSSMDRVNTALQRAQMKVCSLSNQRMGRSLLKSKDLLKQRYLFAKAGYPLRRSQSLPTTLLSPVRVVSSVNVRLSPGKETRCSPPSFTYKYTPEEEQELEKRVMEHDGQSLVKSTIFISPSSVKKEEAPQSEAPRVEECHHGRTPTCSRLAPPPMSQSTCSLHSIHSEWQERPLCEHTRTLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRVCSVNPPSAIEMQLRRVLHDIRNSLQNLSQYPMMRGPDPAAAPYSTQKSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELAMLRQQTMVYHHMTEEERFEVDQLQGLRNSVRMELQDLELQLEERLLGLEEQLRAVRMPSPFRSSALMGMCGSRSADNLSCPSPLNVMEPVTELMQEQSYLKSELGLGLGEMGFEIPPGESSESVFSQATSESSSVCSGPSHANRRTGVPSTASVGKSKTPLVARKKVFRASVALTPTAPSRTGSVQTPPDLESSEEVDAAEGAPEVVGPKSEVEEGHGKLPSMPAAEEMHKNVEQDELQQVIREIKESIVGEIRREIVSGLLAAVSSSKASNSKQDYH
Protein: Transmembrane glycoprotein, putative (AFU_orthologue AFUA_1G09270) (C8VRX0)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Uncharacterized protein
Sequence:
MAHRLFIILSFLLSAASAAVLANYPVNAQLPPVARISKPFHFVFSQSTFSGSGPQTVYSLSNAPSWLSVDNTSRTLSGTPQKEDAGSPEFDLIATDPSGSASMQVTLVVTGDDGPKVGKPIVPQLQAIGPTSSPSNVIVHSSASFSISFDQETFSNTRPSTVYYGTSYPDNAPLPSWIRFDQSNLRFYGTAPNIGPQTFSLNLVASDVTGFSAATISFELTVSPHILSFKQSAQTMFVTGVKALKSPQFLNSLTLDGNIPTSDVLTETVIDAPDWLEVDKQTLSFKGDPPADGKNSNVTISVKDIYQNVAKLVVSLQYSEFFQEGFRDECDAIIGQYFFFTFNSTALTDESAELDVDLDKQLSWLHYNRDNKTLYGEVPSDLLPNTYKVRLTAHKGTAEGHKTLMINTVTEDDLNEDGASSADSNGYHAGKAGIIVMAIFIPLGCTGIALLLLYCRRRRQRWTKDEGGPGFEEKSLAPNPFGPGLSHCQPFEKTTPGNPPAIRTAPLPESKPPKLELEPWWNVSSEIRNGDPPTASGKENTFSSSTIDWDFVPLRGPEGDENKPPEEPAPKTHRLSLQSSPPVRRGTSNRSGRREPLRQIQPRRSTKRNSAVSSRSKRWSKRSSGISSISAGLPVRLSGAGHGAGGFGPPGHGFVKLPWQNTQTSLQSEESSLGNLAPLFPRPPARTGDSQDPTKRMSVHTVDRDSSTLSDSDSLEAFVQGRARSRHSSNPFIAGPISRRVSSKTRALQRARSNASRADTVNTAMDNDDYQRRERPWSLAMSGSVYTDDYRHSAYLSSLSEESPRTQPLNALPSQSSLAQHYSKIISPLPRYFSELSLNNIRHDETGGAYVPADQQNLSGTRRWSRSSPSLQNWRRFQKSPSASSFPYDARTRRVSLMQTADQDSNSQRGFQREPTGSVLSDIAFV