wanglab/gogpt-training-data huggingface dataset:
Protein: F-box DNA helicase 1 (hFBH1) (EC 5.6.2.4) (DNA 3'-5' helicase 1) (F-box only protein 18) (Q8NFZ0)
Organism: Homo sapiens (Human)
Function: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location.
Subcellular location: Nucleus {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23677613}. Chromosome {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23319600, ECO:0000269|PubMed:23677613}. Note=Accumulates at sites of DNA damage or replication stress (PubMed:19736316, PubMed:23677613). PCNA is required for localization to DNA damage sites (PubMed:23677613). Localizes to the nucleoplasm in absence of DNA damage (PubMed:23677613). {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23677613}.
Interaction partners:
- S-phase kinase-associated protein 1
- Fanconi anemia group M protein
- Cullin-1
- DNA repair protein RAD51 homolog 1
- ATP-dependent DNA helicase Q5
- Proliferating cell nuclear antigen
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- E3 ubiquitin-protein ligase RBX1
- DNA repair protein RAD52 homolog
- DNA repair protein XRCC3
Sequence:
MRRFKRKHLTAIDCQHLARSHLAVTQPFGQRWTNRDPNHGLYPKPRTKRGSRGQGSQRCIPEFFLAGKQPCTNDMAKSNSVGQDSCQDSEGDMIFPAESSCALPQEGSAGPGSPGSAPPSRKRSWSSEEESNQATGTSRWDGVSKKAPRHHLSVPCTRPREARQEAEDSTSRLSAESGETDQDAGDVGPDPIPDSYYGLLGTLPCQEALSHICSLPSEVLRHVFAFLPVEDLYWNLSLVCHLWREIISDPLFIPWKKLYHRYLMNEEQAVSKVDGILSNCGIEKESDLCVLNLIRYTATTKCSPSVDPERVLWSLRDHPLLPEAEACVRQHLPDLYAAAGGVNIWALVAAVVLLSSSVNDIQRLLFCLRRPSSTVTMPDVTETLYCIAVLLYAMREKGINISNRIHYNIFYCLYLQENSCTQATKVKEEPSVWPGKKTIQLTHEQQLILNHKMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSRFLYVTFNKSIAKQAERVFPSNVICKTFHSMAYGHIGRKYQSKKKLNLFKLTPFMVNSVLAEGKGGFIRAKLVCKTLENFFASADEELTIDHVPIWCKNSQGQRVMVEQSEKLNGVLEASRLWDNMRKLGECTEEAHQMTHDGYLKLWQLSKPSLASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQQIYTFRGAVNALFTVPHTHVFYLTQSFRFGVEIAYVGATILDVCKRVRKKTLVGGNHQSGIRGDAKGQVALLSRTNANVFDEAVRVTEGEFPSRIHLIGGIKSFGLDRIIDIWILLQPEEERRKQNLVIKDKFIRRWVHKEGFSGFKRYVTAAEDKELEAKIAVVEKYNIRIPELVQRIEKCHIEDLDFAEYILGTVHKAKGLEFDTVHVLDDFVKVPCARHNLPQLPHFRVESFSEDEWNLLYVAVTRAKKRLIMTKSLENILTLAGEYFLQAELTSNVLKTGVVRCCVGQCNNAIPVDTVLTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAMERTVENIVLPRHEALLFLVF
Protein: Spermatogenesis associated glutamate (E)-rich protein 4D (L7N216)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MWMALRQTSSPVPVISKKQFEKEEKKLIKEIQLTTKETNELRDRLIYVTEESMNKRPYHRQNPLYEKLKLKEKEIMTFLHNLEMENMEAQENKQELKKETHFYRNLHSRLLMEENLIKKKLMTLQQESKEVQADWAIIHQCLVELNLSGKDEQEENSNLETPEYQVSETARELGLATAEEDSILQNELPGQEAPAEHHLQHLQSSSDESSSI
Protein: Protein Turandot X (Q8IN41)
Organism: Drosophila melanogaster (Fruit fly)
Function: A humoral factor that may play a role in stress tolerance.
Subcellular location: Secreted {ECO:0000269|PubMed:11409894, ECO:0000305}.
Interaction partners:
- Protein Turandot C
- Protein Turandot M
- Protein Turandot A
Sequence:
MGLSIGSLLICVFLGIVPFATANTNSSSYEEHRNYLLNIFHNPFVNDSIKEKNIPQLIAFYQRYPTDVPLSDADRQQFERFIHDYREYRAVLVDGAPPQGGSFGNIFGHFLGRVGTRYISSLFNKKREERKSNHAYIIEDYN
Protein: UDP-glucuronic acid decarboxylase 2 (EC 4.1.1.35) (UDP-XYL synthase 2) (UDP-glucuronate decarboxylase 2) (UGD) (UXS-2) (dTDP-glucose 4-6-dehydratase homolog D18) (Q9LZI2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:15655675}; Single-pass type II membrane protein {ECO:0000269|PubMed:15655675}.
Interaction partners:
- UDP-D-apiose/UDP-D-xylose synthase 1
- UDP-glucose 6-dehydrogenase 3
- UDP-glucose 6-dehydrogenase 4
- UDP-D-apiose/UDP-D-xylose synthase 2
- UDP-glucose 6-dehydrogenase 2
- UDP-sugar pyrophosphorylase
- Cellulose synthase-like protein D5
- UDP-glucose 6-dehydrogenase 1
- Putative UDP-glucose 6-dehydrogenase
- UDP-glucuronate 4-epimerase 6
Sequence:
MASELINRRHETDQPTADAYYPKPIKPWFTVTRPMRYMLREQRLIFVLVGIAIATLVFTIFPRSTQSTPYSDPFSGYGIRPDESYVPAIQAQRKPSLEYLNRIGATGGKIPLGLKRKGLRVVVTGGAGFVGSHLVDRLMARGDTVIVVDNFFTGRKENVMHHFSNPNFEMIRHDVVEPILLEVDQIYHLACPASPVHYKFNPVKTIKTNVVGTLNMLGLAKRVGARFLLTSTSEVYGDPLQHPQVETYWGNVNPIGVRSCYDEGKRTAETLTMDYHRGANVEVRIARIFNTYGPRMCIDDGRVVSNFVAQALRKEPLTVYGDGKQTRSFQFVSDLVEGLMRLMEGEHVGPFNLGNPGEFTMLELAKVVQETIDPNANIEFRPNTEDDPHKRKPDITKAKELLGWEPKVSLRQGLPLMVKDFRQRVFGDQKEGSSAAATTTKTTSA
Protein: Epididymis secretory sperm binding protein (A0A384NKJ3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARRFGSQRVLVEPDAGAGVAVMKFKNPPVNSLSLEFLTELVISLEKLENDKSFRGVILTSDRPGVFSAGLDLTEMCGRSPAHYAGYWKAVQELWLRLYQSNLVLVSAINGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYLERLKEEKG
Protein: Transcription factor SOX-6 (P35712)
Organism: Homo sapiens (Human)
Function: Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:16442531}. Cytoplasm {ECO:0000250|UniProtKB:P40645}.
Interaction partners:
- Transcription factor SOX-5
- Transcription factor SOX-9
- Histone deacetylase 1
- BCL11 transcription factor A
- Erythroid transcription factor
- Catenin beta-1
- Transcriptional regulator protein Pur-beta
- Myosin-7B
- Collagen alpha-1
- Krueppel-like factor 1
Sequence:
MSSKQATSPFACAADGEDAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINQRLKGLSDRFGRNLDTFEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNTAGTVSPTGIKNEKRGTSPVTQVKDEAAAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQQPHGVDGKLSSINNMGLNSCRNEKERTRFENLGPQLTGKSNEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKTDGGSLAGNEMINGEDEMEMYDDYEDDPKSDYSSENEAPEAVSAN
Protein: Kynureninase (EC 3.7.1.3) (Biosynthesis of nicotinic acid protein 5) (L-kynurenine hydrolase) (Q05979)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Kynurenine 3-monooxygenase
- 3-hydroxyanthranilate 3,4-dioxygenase
- Indoleamine 2,3-dioxygenase
- Kynurenine formamidase
- Probable kynurenine--oxoglutarate transaminase BNA3
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Catalase T
- Peroxisomal catalase A
- Nicotinate phosphoribosyltransferase
- Glutamine-dependent NAD
Sequence:
MEKALELDGEYPESLRDEFNIPTFKSMGLSSDDKPVTYLCGNSLGLMPKSTRNSINAELDAWSDCAVESHFKHPEEARGKVPWVSIDLPILPLLAPIVGAQENEVAVMNSLTANLNSLLITFYKPTEKRFKILFEKGSFPSDYYAFYNQCKIHGISEPENVFIQIEPREGETYIRTQDILDTIEVNQDELALVCLSGVQYYTGQYFDIGRITSFAHQFPDILVGWDLAHAVGNVPLQLHDWGVDFACWCSYKYLNAGPGGIGGLFVHSKHTKPDPAKESLPRLAGWWGNDPAKRFQMLEVFEPIPGALGFRQSNPSVIDTVALRSSLELFAKFNGINEVRKRSLLLTNYMTELLEASKYYKHPLRIEKLPCFFTILTPTSTDEEHGAQLSLYFDSDTGKEDIMPKVFQYLHDHGVIGDARRPNVIRLAPAPLYNTFSDVYIAVNALNEAMDKL
Protein: Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) (P43006)
Organism: Mus musculus (Mouse)
Function: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:7557442, ECO:0000269|PubMed:7698742, ECO:0000269|PubMed:9373176}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43004}.
Interaction partners:
- Aquaporin-4
- Excitatory amino acid transporter 1
- Excitatory amino acid transporter 5
- Alpha-synuclein
- Glutamine synthetase
- Glial fibrillary acidic protein
- ATP-sensitive inward rectifier potassium channel 10
- Huntingtin
- Cytosolic 10-formyltetrahydrofolate dehydrogenase
- Glutamate receptor ionotropic, NMDA 1
Sequence:
MASTEGANNMPKQVEVRMHDSHLSSDEPKHRNLGMRMCDKLGKNLLLSLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISMLNETMNEAPEETKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRMQEDIEMTKTQSIYDDKNHRESNSNQCVYAAHNSVVIDECKVTLAANGKSADCSVEEEPWKREK
Protein: Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264) (Q9UBN6)
Organism: Homo sapiens (Human)
Function: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 10
- Tumor necrosis factor receptor superfamily member 10B
- Tumor necrosis factor receptor superfamily member 10C
- Tumor necrosis factor receptor superfamily member 10A
- Cellular tumor antigen p53
- Dedicator of cytokinesis protein 5
- CASP8 and FADD-like apoptosis regulator
Sequence:
MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQELAELTGVTVELPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL
Protein: Large ribosomal subunit protein uL30 (60S ribosomal protein L7) (P18124)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}.
Interaction partners:
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS3
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein eL22
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS4
Sequence:
MEGVEEKKKEVPAVPETLKKKRRNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN
Protein: ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1) (Q8IYB8)
Organism: Homo sapiens (Human)
Function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:17352692}. Mitochondrion matrix {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:19864255}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.
Interaction partners:
- Polyribonucleotide nucleotidyltransferase 1, mitochondrial
- Exosome complex exonuclease RRP44
- DIS3-like exonuclease 1
- Putative protein SEM1, isoform 2
- Exosome complex component RRP42
- Exosome complex component 10
- Exosome complex component RRP46
- Exosome complex component RRP43
- Exosome complex component RRP4
- Exosome complex component RRP40
Sequence:
MSFSRALLWARLPAGRQAGHRAAICSALRPHFGPFPGVLGQVSVLATASSSASGGSKIPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKVLDKFYKRKEIQKLGADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIVLNDICFGAAHADDLFPFFLRHAKQIFPVLDCKDDLRKISDLRIPPNWYPDARAMQRKIIFHSGPTNSGKTYHAIQKYFSAKSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERVTVQPNGKQASHVSCTVEMCSVTTPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGEPAAIDLVMELMYTTGEEVEVRDYKRLTPISVLDHALESLDNLRPGDCIVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSINEKGERELEPITTSQALQIAGRAGRFSSRFKEGEVTTMNHEDLSLLKEILKRPVDPIRAAGLHPTAEQIEMFAYHLPDATLSNLIDIFVDFSQVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVLDLYLWLSYRFMDMFPDASLIRDLQKELDGIIQDGVHNITKLIKMSETHKLLNLEGFPSGSQSRLSGTLKSQARRTRGTKALGSKATEPPSPDAGELSLASRLVQQGLLTPDMLKQLEKEWMTQQTEHNKEKTESGTHPKGTRRKKKEPDSD
Protein: tRNA-specific adenosine deaminase (EC 3.5.4.33) (A0A0H2UMZ1)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MYYTLEEKEVFMREALREAEIALEHDEIPIGCVIVKDGEIIGRGHNAREELQRAVMHAEIMAIEDANLSEESWRLLDCTLFVTIEPCVMCSGAIGLARIPNVVYGAKNQKFGAAGSLYNILTDERLNHRVEVEIGILEDECAAIMQDFFRNRRKK
Protein: Ubiquitin-like protein ATG12 (C1IDX9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTSREHQVSLCNCVPLLRRLLCDAPWRKARPLHALSRYFRSRVSPSKMAEEPQSVLQLPTSIAAGGEGLTDVSPETTTPEPPSSAAVSPGTEEPAGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTIQGLIDFIKKFLKLVASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG
Protein: Probable heat shock protein ssa2 (O59855)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Mitochondrial protein import protein mas5
- Heat shock protein 60, mitochondrial
- Heat shock protein 104
- Protein psi1
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor cwf10
- Heat shock protein 90 homolog
- Heat shock factor protein
- Heat shock protein sti1 homolog
- Pre-mRNA-splicing factor brr2
Sequence:
MSKSIGIDLGTTYSCVGHFSNNRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTIFDAKRLIGRKFDDPEVQSDMKHWPFKVISKDGKPVLQVEYKGETKTFTPEEISSMVLMKMRETAEAYLGGKVTDAVVTVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDRSNQGESNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDSRLVNHFIQEFKRKNKKDITGNARAVRRLRTACERAKRTLSSSAQASIEIDSLFEGIDFYTSITRARFEELCADLFRKTMEPVERVLRDSKVDKASVNEIVLVGGSTRIPRVQKLVSDFFNGKEPCKSINPDEAVAYGAAVQAAVLTGDTSEKTQDLLLLDVAPLSMGIETAGGVMTPLIKRNTTIPTKKSEIFSTYSDNQPGVLIQVFEGERARTKDCNLLGKFELSGIPPAPRGVPQIEVTFDVDANGILNVSALEKGTGKTQKITITNDKGRLSKEEIDRMVAEAEKYKAEDEAESGRIQAKNHLESYAYSLRNSLDDPNLKDKVDASDKETVDKAVKETIEWLDSNTTAAKDEFEAKQKELESVANPIMAKIYQAGGAPGGMPGAAPGAAPGAAPGAAPGGDNGPEVEEVD
Protein: E3 ubiquitin-protein ligase SPL1 (EC 2.3.2.27) (DIAP1-like protein 2) (RING-type E3 ubiquitin transferase SPL1) (SP1-like protein 1) (Q94HV7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses E3 ubiquitin-protein ligase activity.
Subcellular location: Plastid, chloroplast outer membrane {ECO:0000269|PubMed:23118188}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Triglyceride lipase
- F20H23.8 protein
- Chloroplastic import inner membrane translocase subunit HP30-1
- Mitochondrial import inner membrane translocase subunit TIM22-3
- YlmG homolog protein 1-1, chloroplastic
- Argininosuccinate lyase
- Chloroplastic import inner membrane translocase subunit TIM22-2
- 3-oxo-5-alpha-steroid 4-dehydrogenase family protein
- Chloroplastic import inner membrane translocase subunit HP30-2
- Subtilisin-like protease SBT2.5
Sequence:
MIHLAGFTCCLGGVALYLLTRSTGRDIKSITRVYQLKDLEQLVEVESKVVPLIIAVSGDVGSETPIKCEHSYVLGVFLKRTAEQQVLRRNWRFSWVRNSTLMQPMTKEVPWYLDDGTGRVNVDVSQGELGLALTVGSDVFEKAEPVSLVQGALGYLKGFKILGVRHVERVVPIGTPLTVVGEAVRDGMGNVRIQKPEQGPFYVTYIPLDQLISKLGDLSRRFKYASMGLTVLGVILISKPVIEYILKRIEDTLERRRRQFALKRVVDAAARRAKPVTGGGTSRDGDTPDLCVVCLDQKYNTAFVECGHMCCCTPCSLQLRTCPLCRERIQQVLKIYRH
Protein: Low-specificity L-threonine aldolase 1 (EC 4.1.2.48) (Threonine aldolase 1) (Q8RXU4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Threonine aldolase involved in threonine degradation to glycine. May play a role in the removal of L-allo-threonine.
Interaction partners:
- Threonine dehydratase biosynthetic, chloroplastic
- Serine--glyoxylate aminotransferase
- Glycine dehydrogenase
- Glycine dehydrogenase
- Threonine synthase 1, chloroplastic
- Probable sarcosine oxidase
- Threonine synthase 2, chloroplastic
- Serine hydroxymethyltransferase 7
- Serine hydroxymethyltransferase 6
- Serine hydroxymethyltransferase 5
Sequence:
MVMRSVDLRSDTVTRPTDAMREAMCNAEVDDDVLGYDPTARRLEEEMAKMMGKEAALFVPSGTMGNLISVMVHCDVRGSEVILGDNCHIHVYENGGISTIGGVHPKTVKNEEDGTMDLEAIEAAIRDPKGSTFYPSTRLICLENTHANSGGRCLSVEYTEKVGEIAKRHGVKLHIDGARLFNASIALGVPVHKLVKAADSVQVCLSKGLGAPVGSVIVGSQSFIEKAKTVRKTLGGGMRQIGVLCAAALVALQENLPKLQHDHKKAKLLAEGLNQMKGIRVNVAAVETNMIFMDMEDGSRLTAEKLRKNLEENGILLIRGNSSRIRIVIHHQITTSDVHYTLSCFQQAMLTMQEPSRT
Protein: Transcription factor Dp family member 3 (Cancer/testis antigen 30) (CT30) (Hepatocellular carcinoma-associated antigen 661) (Q5H9I0)
Organism: Homo sapiens (Human)
Function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.
Subcellular location: Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members.
Interaction partners:
- Transcription factor E2F4
- Activator of apoptosis harakiri
- Transcription factor E2F5
- Transcription factor E2F8
- Transcription factor E2F7
- Transcription factor E2F6
- Transcription factor E2F3
- Adenomatous polyposis coli protein
- Dipeptidyl peptidase 8
- Transcription factor E2F1
Sequence:
MAKYVSLTEANEELKVLMDENQTSRPVAVHTSTVNPLGKQLLPKTFGQSSVNIDQQVVIGMPQRPAASNIPVVGSPNPPSTHFASQNQHSYSSPPWAGQHNRKGEKNGMGLCRLSMKVWETVQRKGTTSCQEVVGELVAKFRAASNHASPNESAYDVKNIKRRTYDALNVLMAMNIISREKKKIKWIGLTTNSAQNCQNLRVERQKRLERIKQKQSELQQLILQQIAFKNLVLRNQYVEEQVSQRPLPNSVIHVPFIIISSSKKTVINCSISDDKSEYLFKFNSSFEIHDDTEVLMWMGMTFGLESGSCSAEDLKMARNLVPKALEPYVTEMAQGTFGGVFTTAGSRSNGTWLSASDLTNIAIGMLATSSGGSQYSGSRVETPAVEEEEEEDNNDDDLSENDEDD
Protein: Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1) (Q62674)
Organism: Rattus norvegicus (Rat)
Function: Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11375981, ECO:0000269|PubMed:8027026, ECO:0000269|PubMed:8967974}; Multi-pass membrane protein {ECO:0000269|PubMed:11375981}. Apical cell membrane {ECO:0000250|UniProtKB:O00337}; Multi-pass membrane protein {ECO:0000269|PubMed:11375981}.
Interaction partners:
- Equilibrative nucleoside transporter 2
- Equilibrative nucleoside transporter 1
- Equilibrative nucleoside transporter 3
Sequence:
MADNTQRQRESISLTPMAHGLENMGAEFLESMEEGRLPHSHSSLPEGEGGLNKAERKAFSRWRSLQPTVQARSFCREHRQLFGWICKGLLSTACLGFLMVACLLDLQRALALLIITCVVLVFLAYDLLKRLLGSKLRRCVKFQGHSCLSLWLKRGLALAAGVGLILWLSLDTAQRPEQLVSFAGICVFLVLLFAGSKHHRAVSWRAVSWGLGLQFVLGLFVIRTEPGFIAFQWLGDQIQVFLSYTEAGSSFVFGEALVKDVFAFQVLPIIIFFSCVMSVLYYLGLMQWVILKIAWLMQVTMGTSATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDAASLIAASVMAAPCALALSKLVYPEVEESKFRSENGVKLTYGDAQNLLEAASAGAAISVKVVANIAANLIAFLAVLAFVNAALSWLGDMVDIQGLSFQLICSYVLRPVAFLMGVAWEDCPVVAELLGIKFFLNEFVAYQELSQYKQRRLAGAEEWLGDKKQWISVRAEILTTYALCGFANFSSIGIMLGGLTSLVPQRRSDFSQIVLRALITGAFVSLLNACVAGILYVPRGVEVDCVSLLNQTVSSSSFEVYLCCRQVFQSTSSEFSQVALDNCCRFYNHTVCT