wanglab/gogpt-training-data huggingface dataset:
Protein: Probable mannosyltransferase KTR5 (EC 2.4.1.-) (P53966)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLLIRRTINAFLGCIHCNLTATCILIAFVITMYVVLVSEPASVDGTMGNFLPFSKMDLATKRDRPFYSNCVNTQDYLLNPSYIKQNASFVMLTRNGELEDVIKTINSIEEHFNQWFHYPYVFLNDQPFEEDFKAKVRDVTVGALVEFGTIDEISWNFPSDVKDTFEFYNAIEDQGDRSILYGNLESYHKMCRFYSGLFYKHPLVQKYEWYWRLEPDVEFFCDITYDPFLEMLRTNKKYGFTIIIPELYWTVPNLFRHTKSFISQKGVTLGSLWKLFTKDYDIFESDDPELRDWINYDFQAKAKISEKIAIEQLLKKGDDFQQINDDKEGIMNLIHKARSRKHIVEDKFFNEEYNLCHFWSNFEIARLSVFDNDIYNSFFQYLEKSGGFWKERWGDAPVHSIGLSLTLDLDDVHYFRDIGYRHSTIQHCPHNAMGNEEFSYLASDSKFKRKNAAYDEGREFGCGCRCRCPKKKREIEDSMGFCVNIWVNLLNQQRGHERHVEALNGNEMEEHIREDYLRQFGN
Protein: CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) (P17676)
Organism: Homo sapiens (Human)
Function: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation. Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:20829347}. Cytoplasm {ECO:0000269|PubMed:9374525}. Note=Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). {ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:9374525}.
Interaction partners:
- Cyclic AMP-dependent transcription factor ATF-4
- Histone acetyltransferase p300
- Histone-lysine N-methyltransferase PRDM16
- CCAAT/enhancer-binding protein delta
- DNA damage-inducible transcript 3 protein
- Histone deacetylase 1
- CCAAT/enhancer-binding protein alpha
- Peroxisome proliferator-activated receptor gamma
- Signal transducer and activator of transcription 3
- Transcriptional activator Myb
Sequence:
MQRLVAWDPACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGPRPPAGELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAPPAPAPAPASSGQHHDFLSDLFSDDYGGKNCKKPAEYGYVSLGRLGAAKGALHPGCFAPLHPPPPPPPPPAELKAEPGFEPADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPSPADAKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASSGHC
Protein: PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog) (Q8BLG0)
Organism: Mus musculus (Mouse)
Function: Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage (By similarity). Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.
Subcellular location: Nucleus {ECO:0000269|PubMed:22072714}.
Interaction partners:
- KAT8 regulatory NSL complex subunit 2
- KAT8 regulatory NSL complex subunit 1
- KAT8 regulatory NSL complex subunit 3
- WD repeat-containing protein 5
- Microspherule protein 1
- Histone acetyltransferase KAT8
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
- Host cell factor 1
- Mortality factor 4-like protein 1
- Retinoblastoma-binding protein 5
Sequence:
MTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGRVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHDEDGSSEFQINQQVLACWSDCRFYPARVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPEKREKFKEQRKVTVNVKKDKVEKALKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENEREYSGDAQVEKKPEKDLVKNPQENLKEPKRKRGRPPSITPTAVDSNSQTLQPITLELRRRKISKRSDTPLKRPRLDKNSPQEQSKKRSENSDKDLSRRRSSRLSTNGTREILDPDSIVPDLVHTVDTNPLPDKSPSAKDSAEGQLKSPLEAGQVSSALTCHPIGDGLGAADLELNCKSMGENTMKTEPVSPLAEVQEVSTVEVPNTLKKVDDSVTLNVPAVDLDHKFRCKVLDCLKFFRKAKLLHYHMKYFHGMEKSPEPEEGPGKTHVQTRGSAVPDKTSQESLTRKRVSASSPTAKEKEKTKEKKFKELVRVKPKKKKKKKKKTKPECPCSEDISDTSQEPSPPKTFAVTRCGSSHKPGVHMSPQLHGSDNGNHKGKLKTCEEDNLSESSSESFLWSDEEYGQDVDVTTNPDEELEGDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLDQNYSHQNARKIVATHQLLGDVQRVIQVLHGLQLKMSILQSREHPDLQLWCQPWKQHSGEGRAHPRHIHITDARSEESPSYRTLNGAVEKPSPLPRSVEESYITSEHCYQKPRAYYPAVEQRLVVETRGSALDAAVSPLCENGDDSLSPRLGWPIDQDRSRGDIDPKPSSPKVREYISKNVLPEETPARKLLDRGGEGLVSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLPQLKHCIKQLLTDLGKVQQIALCCST
Protein: Probable xyloglucan endotransglucosylase/hydrolase protein 32 (At-XTH32) (XTH-32) (EC 2.4.1.207) (Q9SJL9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity).
Subcellular location: Secreted, cell wall {ECO:0000305}. Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Protein SODIUM POTASSIUM ROOT DEFECTIVE 3
Sequence:
MGNSLISLLSIFHLLVLWGSSVNAYWPPSPGYWPSSKVGSLNFYKGFRNLWGPQHQRMDQNALTIWLDRTSGSGFKSVKPFRSGYFGANIKLQPGYTAGVITSLYLSNNEAHPGFHDEVDIEFLGTTFGKPYTLQTNVYIRGSGDGKIIGREMKFRLWFDPTKDFHHYAILWSPREIIFLVDDIPIRRYPKKSASTFPLRPMWLYGSIWDASSWATEDGKYKADYKYQPFTAKYTNFKALGCTAYSSARCYPLSASPYRSGGLTRQQHQAMRWVQTHSMVYNYCKDYKRDHSLTPECWR
Protein: Polyubiquitin [Cleaved into: Ubiquitin] (P0CG63)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250|UniProtKB:Q15843}.
Interaction partners:
- E3 ubiquitin-protein ligase RSP5
- Ubiquitin-conjugating enzyme E2 1
- Ubiquitin carboxyl-terminal hydrolase 6
- Ubiquitin-activating enzyme E1 1
- 26S proteasome regulatory subunit RPN3
- Ubiquitin-ribosomal protein eL40A fusion protein
- Proteasome subunit beta type-4
- Ubiquitin-conjugating enzyme E2 13
- Ubiquitin-ribosomal protein eS31 fusion protein
- 26S proteasome regulatory subunit RPN10
Sequence:
MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGN
Protein: PE-PGRS family protein PE25 (I6X486)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: The PE25/PPE41 dimer induces both a strong humoral and cellular immune response. PE25 protein alone induces low response. The dimer induces necrosis, but not apoptosis, in mouse macrophage cells. It also induces activation and maturation of mouse dendritic cells and drives Th2-biased immune responses.
Subcellular location: Secreted {ECO:0000305}. Note=Secreted via the ESX-5 / type VII secretion system (T7SS). {ECO:0000305}.
Interaction partners:
- PPE family protein PPE41
- ESX-5 secretion-associated protein EspG5
- Esterase PE16
- Triacylglycerol lipase
Sequence:
MSFVITNPEALTVAATEVRRIRDRAIQSDAQVAPMTTAVRPPAADLVSEKAATFLVEYARKYRQTIAAAAVVLEEFAHALTTGADKYATAEADNIKTFS
Protein: NF-X1-type zinc finger protein NFXL2 (AtNFXL2) (EC 2.3.2.-) (Protein EARLY BIRD) (Q9FFK8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcriptional regulator. May mediate E2- or E3-dependent ubiquitination. Required to gate light sensitivity during the night. Regulates the speed of the clock by acting in the feedback loop between CCA1, LHY and APRR1/TOC1. Promotes the expression of CCA1 at night but not by days. This activational effect is enhanced by interaction with ADO1/ZTL. Association with ADO1/ZTL is not leading to the degradation of NFXL2. Confers sensitivity to osmotic stress such as high salinity. Prevents H(2)O(2) production and abscisic acid accumulation. Part of a regulatory network that integrates the biosynthesis and action of abscisic acid, reactive oxygen species and cuticle components.
Subcellular location: Nucleus {ECO:0000269|PubMed:22073231}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 12 homolog A
- Protein CDC73 homolog
- Peptidyl-prolyl cis-trans isomerase FKBP12
- Cytidine deaminase 1
- Puromycin-sensitive aminopeptidase
- Large ribosomal subunit protein uL18y
- At4g13350
- Small ribosomal subunit protein eS12y
- Small ribosomal subunit protein eS12z
Sequence:
MTNMAGTATTEFRWKSPPQPPSQEQPISDSDSDSGSDSENHQHRHNDLSNSIFEAYLDCHSSSSPSSIDLAKIQSFLASSSSGAVSCLICLERIKRTDPTWSCTSSCFAVFHLFCIQSWARQCLDLQAARAVTRPSSNPTEPEAVWNCPKCRSSYQKSKIPRRYLCYCGKEEDPPADNPWILPHSCGEVCERPLSNNCGHCCLLLCHPGPCASCPKLVKAKCFCGGVEDVRRCGHKQFSCGDVCERVLDCNIHNCREICHDGECPPCRERAVYKCSCGKVKEEKDCCERVFRCEASCENMLNCGKHVCERGCHAGECGLCPYQGKRSCPCGKRFYQGLSCDVVAPLCGGTCDKVLGCGYHRCPERCHRGPCLETCRIVVTKSCRCGVTKKQVPCHQELACERKCQRVRDCARHACRRRCCDGECPPCSEICGKKLRCRNHKCQSPCHQGPCAPCPIMVTISCACGETHFEVPCGTETNQKPPRCRKLCHITPLCRHGQNQKPHKCHYGACPPCRLLCDEEYPCGHKCKLRCHGPRPPPNREFILKPTKKMLHIQAESTPGSPCPRCPEPVWRPCVGHHLAAEKRMICSDRTQFACDNLCGNPLPCGNHYCSYFCHALDIRSSSLDKRSESCEKCDLRCQKERTPRCQHPCPRRCHPEDCPPCKTLVKRSCHCGAMVHAFECIYYNTMSEKDQMKARSCRGPCHRKLPNCTHLCPEICHPGQCPLPEKCGKKVVVRCKCLTLKKEWVCQDVQAAHRATGSDPKEVPKNQFGVGLLPCDSNCKSKLQVAESVLTQRNVKEIEEKEEPSGKNASKRRKRRGRGQDIQETTRLQKLAVTTKRILMVVMLVAMLAAVSYYGYKGLLWLSDWMNEVEEQRQKSRRYPRI
Protein: Putative cation exchanger C3A12.06c (P87122)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Putative cation exchanger.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized Na
- Na
Sequence:
MSKTSCFLKKYRLILLWCILGIAYILFWTHRISKAFASVSSTSDSTVHLFERGNTLNDSNDQILLTCNDIKNITPANQCRFAKAYCKGEASGFFDYVEFYFCTINSLRFPVLSIIVGWLIFLFITIGISASDFFSTNLVTISWLLQLPDSVVGVTFLALGNGSPDILSTFAAVRVNSGGMAIGELLGSAFFIVAIVAGSVCLIKPFKIPRRHFLRDVAFLTGTILLVIMFVLHDGSLSIWQSLVMILYYLLYVLFVFFSGSSGVSVVITDENYLPVSLPVYSPVLNSFDDSDSYSSTDSELSEEAFLLPAQASRKTQKIHYINDNDPSNSYSSYQHSHVHDFIHKNNTHSNRVLSQSSGPIVRPSLLAALDFRSSNEEQHPGLRSLDPLNIQDGDLTMHPMHIRHSQSDFYPSGINTPVSGINYPNLGFSANNSVQSLVSEIFRHPTHTDEDFPLPSPSLSSLLFPTLRNFAKKSWYEKLMDVLAVPSVLIFTLALPVYQCPRLAVDPIYHMDVSNCNPSKPTWSRKLRLLQCVFVPFAFVTFSITGGNRLYIYAASSVFSILCITALYYYTDEEKPPKFLPWVSFIGFVLGIIWISTIANEVVGILRALGVIFNLNESILGLTVFAAGNSLSDLIADIMIARSGFPEMAMGGVFGGPTLNILIGIGISSFYSSISNHGNDSVIEIPHSLSITAYFLLACLLLLLIYVPLNRFRVNRVLGLLLFILYIVGTSTNIVVELLKDK
Protein: Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (A0A1B0GWJ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVSF
Protein: Vinexin (SH3 domain-containing protein SH3P3) (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3) (Q9R1Z8)
Organism: Mus musculus (Mouse)
Function: Promotes up-regulation of actin stress fiber formation.
Subcellular location: Cell junction, focal adhesion. Cell junction. Cytoplasm, cytoskeleton. Note=Localized at focal adhesion sites, cell-cell junctions and cell-extracellular matrix junctions.
Interaction partners:
- Vinculin
- Talin-1
- Paxillin
- Integrin alpha-1
- Integrin beta-5
- Talin-2
- GTP cyclohydrolase 1
- Vacuolar protein sorting-associated protein VTA1 homolog
Sequence:
MARILGVGRSSASSLNNKEDNESDVALLSPKDPNRVHTKEQLAHPASSNLDPSMQGLPAGLSLDDFIPGHLRTHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGCPPPRRDGSLNPDPAWYQTWPGPGSRPSMSPKPPASQHAQNWSATWTKDSKRQDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFQQIHRKMPDLQLDWTLEDPPKVVSARASSAEPRHLGTLQRPASRPGTTETSSGRNWNHSEETSRNTFNYNFRPSSSGLHPPNQVPRHREKVENVWTEDSWNQFLHELETGHKPKKPLVDDPVEKPAQPIEVLLERELAKLSAELDKDLRAIETRLPSPKNSQAPRRPLEQPGLEQQPSARLSSAWRPNSPHAPYFSSSRPLSPHRMADGGGSPFLGRRDFVYPSSAREPSASERGSSPSRKEEKKRKAARLKFDFQAQSPKELSLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGDAVAQYTFKGDLEVELSFRKGERICLIRKVNEHWYEGRITGTGRQGIFPASYVQINREPRLRLCDDGPQLPASPNPTTTAHLSSHSHPSSIPVDPTDWGGRTSPRRSAFPFPITLQEPRSQTQSLNTPGPTLSHPRATSRPINLGPSSPNTEIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV
Protein: Exosome RNA helicase MTR4 (EC 3.6.4.13) (Superkiller viralicidic activity 2-like 2) (Q6P7X6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADAFGDDLFSVFDEEQAGSSKKAAPKSAANAGKTPDKAGKPQGDSASLRKRDADDDGPDEMLLGKRQKLETVSAEEINLSELMPKVKSEQVETVEGCTHEVVLPANEEYTPLKPRVGKAAKEYPFILDPFQREAILCIDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHHVFLSATVPNARQFAEWICHLHKQPCHVVYTDYRPTPLQHYIFPAGGDGLHLVVDENGEFREDNFNTAMQVLRDAGDTGGNTGAKWDPKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKECEAYALQVSKLDFNTDEEKKLVEEVFNNATDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLLKALFATETFAMGINMPARTVLFTSARKFDGKDFRWISSGEYIQMSGRAGRRGMDERGIVIFMVDEKMSPAVGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAVPGVVDRMKKLEEEYNAIRIPKEESVVTYYKIRQQLAKLGKEIEEFIHKPRYCLPFLQPGRLVKVKKEDLDFGWGVVVNFQKKSNVKAGGDLDPLFVVEVLVHCSKDSVKNAATESARPAGPAEKGEMQVVPVILHLITSISSVRLYIPKDLRPYDNRQSMLKSIQEVQKRFPDGIPLLDPIDDMGIKDPALKKVIQKVEAFEHRMYTHPLHSDPNLEAVYKLCEKKALIAGDIKAAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACETSSGDELLLTEMMFNGLFNDLTAEQATALLSCFVFQENANEMPKLTEQLGGPLRQMQECAKRIAKVSAEAKLEVDEDSYLNQFRPHLMDVVYTWANGSSFSQICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFATGITKIKRDIVFAASLYL
Protein: ATP-binding cassette sub-family G member 5 (EC 7.6.2.-) (Sterolin-1) (Q9H222)
Organism: Homo sapiens (Human)
Function: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity.
Subcellular location: Cell membrane {ECO:0000305|PubMed:16893193, ECO:0000305|PubMed:27144356}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}. Apical cell membrane {ECO:0000269|PubMed:14504269}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}.
Interaction partners:
- ATP-binding cassette sub-family G member 8
- Lysosomal cobalamin transporter ABCD4
- ATP-binding cassette sub-family B member 6
- ATP-binding cassette sub-family A member 2
- Sterol regulatory element-binding protein 2
- Solute carrier family 53 member 1
- Oxysterols receptor LXR-alpha
- Cytochrome P450 7A1
- NPC1-like intracellular cholesterol transporter 1
- Oxysterols receptor LXR-beta
Sequence:
MGDLSSLTPGGSMGLQVNRGSQSSLEGAPATAPEPHSLGILHASYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSAICHKTLKNIERMKHLKTLPMVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLISR
Protein: Melanoma-associated antigen B3 (MAGE-B3 antigen) (O15480)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPRGQKSTLHAREKRQQTRGQTQDHQGAQITATNKKKVSFSSPLILGATIQKKSAGRSRSALKKPQRALSTTTSVDVSYKKSYKGANSKIEKKQSFSQGLSSTVQSRTDPLIMKTNMLVQFLMEMYKMKKPIMKADMLKIVQKSHKNCFPEILKKASFNMEVVFGVDLKKVDSTKDSYVLVSKMDLPNNGTVTRGRGFPKTGLLLNLLGVIFMKGNCATEEKIWEFLNKMRIYDGKKHFIFGEPRKLITQDLVKLKYLEYRQVPNSNPARYEFLWGPRAHAETSKMKVLEFWAKVNKTVPSAFQFWYEEALRDEEERVQAAAMLNDGSSAMGRKCSKAKASSSSHA
Protein: Annexin (Q5T0G8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAANMSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDIYEIKEAIKGVGTDEACLIEILASRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLAQRDAQELYAAGENRLGTDESKFNAVLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEEGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKSLYHDISGDTSGDYRKILLKICGGND
Protein: Protein hemingway (Q9VE87)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in assembly and/or maintenance of motile cilia. Required during spermatogenesis for axoneme elongation. Necessary for optimal function of the chordotonal (hearing) organs.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:24554765}. Perikaryon {ECO:0000269|PubMed:24554765}. Cytoplasm {ECO:0000269|PubMed:24554765}.
Interaction partners:
- Uncharacterized protein, isoform C
- FI21813p1
- GH27720p
- Uncharacterized protein, isoform A
Sequence:
MSGAGEHSDEESYGEESFEEDSESEVEVEEEEIEYIEPEESKPSDALLLGESDTQSESDVKEEFLSGNPHARRYLGARVVSYLSSSSDDESQVVITKTVAEVNQLSLRVDTPPEDETPSVRTLMPGSAHSRVKDEDEAEDEDDDEGDGENDNDNEDENDDEDAEVEEIEEEEEEIPGDEDDAQSDGSMGRQSADDSDEEEGTDVEVEQLEEDEPIVTAVCKKTVQKELPPPQKDIVSLVDASDNSSEHSVVTMCASGDETDNTLVKYPRLRKQQPLTAKDSQSLKEQEEPEEPEQPEENQTEEHMPTSQPDLARVRYLEQQMTQMSELIMKSFQINGGAPNSQAFEQLAMATEMLQQRSDRRGDTESEMSSMTETTMTSARSLGGGIPPLTMRMERSQEALLTTRSSKLPRPKCRCPSESDLIEHEQKLDMGHELPHDLAANFGLGEGYLVDECGQGDGLMRHPQQRKPMELNRRAVSGTPSTFNSDGCEYQINVSRSRCSNDKINYKNLGRKSFSFTNPQVREIERQNQILLRKMMTVKPTATIKASTSSIKINGPEKRQTPPAPRLSSAAVNRKKNQRQIDLDNDLLKRKLEAIGTRRPQFK
Protein: RE59052p (Q8IGN3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MFLAVNQSLQNTSKKKRKRRTAEDDPQEDSGEGTPPVRPLEPSASSDQLVGVGNGATCRVCKCPGRQSLTLVYIYLGALTLILASLSIVFYTHTQDVESLSQVEDNYSSKSFRVQFQAELMRSEEELRRLVNRIIEEEQELVGSTTASSTTQSRDPLKNERKFTDNLISHTTRPTGKRMRRDIASSAPASMHADPLIEFFNPNHRKVLEEQDTEIRKRTGQKGAAPGGDEWIYLNTYCRVPEKIITGFCKGTQDYCPPAPQGPTGEVGPKGPPGNPGLPGIPGPKGNRGDVGLPGAPGVDGVGHLGPAGPRGPKGDAGATGRAGLDGRDGVPGEPGLDGVPGRAGADGKNGLPGRDGKDGLHGKDGKDGLSITGPKGAQGPPGERGLKGIAGPRGRPGKPGTNGIPGVPGINAWKLQYPNGSSSNDLLIPPSITDIQVPDFQRTVIVEEGRSLNLSCTATGTPTPQVEWRREDGRTVNVNGVEMASISGQFLRFTNITRHQMAAYTCFANNGIAPVANATYLVEVQFAPMISVYRQMIYAEYQSSATLECLVEAFPEAIRYWERAYDGKILDPSDKYGIESYPEGFKTTMRLTISNLRKDDFGYYHCVARNELNATMVNFEIAPQDPNSETPYVGNNMKVYGQRPPESECPVCDQCPDPSLYQCKDSILNNFEIQATGNLSYPGLPKRPKTCYLYAVGKPVFHKVVNEKFGSWLRDPSPDSDREKTFVTNENDPYNLFEFTTRIQYRMNSIPRRKYEIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDLTSLKKITTQLPYAGVAAANRLYTTDYNYMDFNVDEVGLWVIYSTYNSNNTLVAKLDAETLKMQYNFNITLDHHQFGAMFIVCGNLYAIDSGTDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPIRYNEQRLISDNS
Protein: Ras-like GTP-binding protein rhoA (Q22038)
Organism: Caenorhabditis elegans
Function: Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Association with the oxidase bli-3 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:7798239}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23064028, ECO:0000269|PubMed:24016757, ECO:0000269|PubMed:7798239}. Cytoplasm, cell cortex {ECO:0000269|PubMed:23064028}. Note=Associated with the membrane and the cytoskeleton throughout development (PubMed:7798239). Enriched at the anterior cortex in embryos; localization to the anterior cortex requires kin-18 (PubMed:23064028). {ECO:0000269|PubMed:23064028, ECO:0000269|PubMed:7798239}.
Interaction partners:
- Probable rho GDP-dissociation inhibitor
- Rho-associated protein kinase let-502
- FH2 domain-containing protein
- Guanine nucleotide exchange factor
- Protein ECT2
- Actin
- WAPL domain-containing protein
- DH domain-containing protein
- Rho-GAP domain-containing protein
- Serine/threonine-protein kinase mrck-1
Sequence:
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPDVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVRHFCPNVPIILVGNKRDLRSDPQTVRELAKMKQEPVKPEQGRAIAEQIGAFAYLECSAKTKDGIREVFEKATQAALQQKKKKKSKCMIL