Protein: DmX-like protein 2 (Rabconnectin-3) (Q8BPN8)
Organism: Mus musculus (Mouse)
Function: May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles of neuronal and endocrine homeostatic processes (By similarity). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8TDJ6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8TDJ6}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000269|PubMed:25248098}. Note=The external layer of the inferior boundary for the hypothalamus part of the human brain (the so called median eminence (ME)) displayed a punctate pattern of expression; expression also observed in the cell bodies lining the third ventricle, in the long processes extending from these cell bodies toward the external layer of the ME, in small clear vesicles, and in large dense core vesicles. {ECO:0000269|PubMed:25248098}.
Interaction partners:
- WD repeat-containing protein 7
- Protein rogdi homolog
- Rab3 GTPase-activating protein catalytic subunit
- V-type proton ATPase subunit B, kidney isoform
- S-phase kinase-associated protein 1
Sequence:
MHLHQVLTGAVNPGDNCYSVGSVGDVPFTAYGSGCDIVILASDFECVQIIPGAKHGNIQVSCVECSNQHGRVAASYGNAVCIFEPLGVNSHKRNSQLKCQWLKTGQFFLSSVTYNLAWDPQDNRLLTATDSIQLWAPPGGDILEEEEDVDNRAPPVLNDWKCIWQCKTSVSVHLMEWSPDGEYFATAGKDDCLLKVWYPMTGWKSSIIPQDPHEVKRRRASTQFSFVYLAHPRAVTGFSWRKTSKYMPRGSVCNVLLTSCHDGVCRLWAETLLPEDCLLGEQICETTTSSVASNLSSAGKHKDRIQHALETIHHLKNLRKGQRRSSVLVTHAELMPDKTATHEVHRHISHHANALCHFHIAASINPTTDIPNVLVGTAFNIDDINGGFVVHWLNNKEFHFTSSTEIFMHQLRKLSEKQLDHESDDADREDEERSQDERERGLRMKLDHELSLDRESEAGTGSSEHEDGEREGSPRTHPRPSISMPLPTVLLDRKIETLLTEWNKNPDMLFTIHPVDGTFLVWHVKYLDEYNPGIFRQVQVSFSSRIPVAFPSGDANSLSKNIMMYACVNATKDSYNPSQQEMMSVDSPHGSQLHSPSHSTDMNILAPTVMMVSKHIDGSLNQWAVTFADKSAFTTVLTVSHKFRYCGHRFHLNDLACHSVLPLLLTSSHHNALLTPESDCQWDSDSKVNRLIDPVKHTKASSKQPLRNAATRTFHDPNAIYSELILWRVDPIGPLSYTGGVSELARINSLHTSAFSNVAWLPTLIPSYCLGTYCNSASACFVASDGKNLRLYQAVVDARKLLDELSDPEASKLIGEVFNIVSQQSTARPGCIIELDAITDQCGSNTQLLHVFQEDFIIGYKPHKEDMEKKEKESEIFFQPSQGYRPPPFSEKFFLVVIEKDGNNNSILHMWHLHLKSVQACLAKAAEGISSDSLLSVPGQKNLDSSPETSSSMSSVPHSSSIANLQTASKLILSSRLVYSQPLDLPEAVEVIRATPSAGHLSSSSIYPVCLAPYLVVTTCSDNKVRFWKCCMETNSLGNTSDESETYHWRRWPLMNDEGEDNSSTVSIVGRPVAVSCSYTGRLAVAYKQPIHHNGFISKEFSMHVCIFECESTGGSEWVLEQTIHLDDLVKVGSVLDSRVSVDSNLFVYSKSDAFLSKDRYLIPNIKHLVHLDWVSKEDGSHILTVGVGANIFMYGRLSGIVSDQTNSKDGVAVITLPLGGSIKQGVKSRWVLLRSIDLVSSVDGTPSLPVSLSWVRDGILVVGMDCEMHVYAQWKHSVKFGNVDADSPVEETIQDHSALKSSMLARKSIVEGAAIPDDVFCSPTVVQDGGLFEAAHALSPTLPQYHPTQLLELMDLGKVRRAKAILSHLVKCIAGEVAIVRDPDAGEGTKRHLSRTISVSGSTAKDTVTIGKDGTRDYTEIDSIPPLPLHALLAADQDTSYRISEDSTKKPQSYEDHIESQSEDQYSELFQVQEITTDDIDLEPEKRENKSKVINLSQYGPACFGQEHARVLSSHLMHSSLPGLTRLEQMFLVALADTVATTSTELDENRDKNYSGRDTLDECGLRYLLAMRLHTCLLTSLPPLYRVQLLHQGVSTCHFAWAFHSEAEEELINMIPAIQRGDPQWSELRAMGIGWWVRNVNTLRRCIEKVAKAAFQRNNEALDAALFYLSMKKKAVVWGLFRSQHDEKMTTFFSHNFNEDRWRKAALKNAFSLLGKQRFEQSAAFFLLAGSLKDAIEVCLEKMEDIQLAMVIARLFESEFETSSTYISILNQKILGCQKDGTGFDCKRLHPDPFLRSLAYWVVKDYTRALDTLLEQTPKEDDEQQVIIKSCNPVVFSFYNYLRTHPLLIRRNLASPEGTLATLGLKTEKNIADKINLIERKLFFTTANAHFKVGCPVLALEVLSKIPKVTKISSLTAKKDQLDSVSGRMENGPSESKPVSRSDGGSGADWSAVTSSQFDWSQPMVTVDEEPLRLDWGDDHDGALEEDDGGGLVMKTTDAKKAGQEQSASDPRALLTPQDEECADGDTEVDVIAEQLKFRACLKILMTELRTLATGYEVDGGKLRFQLYNWLEKEIAALHEICNHESVIKEYSSKAHSTVETERLDQEEMVDKPDIGSYERHQIERRRLQAKREHAERRKLWLQKNQDLLRVFLSYCSLHGAQGGGLASVRMELKFLLQESQQETTVKQLQSPLPLPTTLPLLSASIASTKTVIANPVLYLNNHIHDILYTIVQMKTPPHPSVEDVKVHTLHSLAASLSASIYQALCDSHSYSQSEGNQFTGMAYQGLLLSDRRRLRTESIEEHATPNSAPAQWPGVSSLINLLSSAQDEDQPKLNVLLCEAVVAVYLSLLIHALATNSSNELFRLAAHPLNNRMWAAVFGGGVKLVVKPRRQSESIAAPPVASEDMDKHRRRFNMRMLVPGRPVKDATPPPVPAERPSYKEKFIPPELSMWDYFVAKPFLPLSDSGVIYDSDESVHSDDEEDDAFFSDTQIQEHQDPNSYSWALLHLTMVKLALHNIKNFFPIAGLEFSELPVTSPLGIAVIKNLENWEQILQEKMDHFEGPPPNYVNTYPTDLSVGAGPAILRNKAMLEPENTPFKSRDSSALPVKRLWHFLVKQEVLQETFIRYIFTKKRKQSEVEADLGYPGGKAKVIHKESDMIMAFSINKANCNEIVLASTHDVQELDVTSLLACQSYIWIGEEYDRESKSSDDIDYRGSTTTLYQPGAASHSSSQPHPPPSLPWLGSGQTSTGATVLMKRNLHNVKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVNQTASNPKPYMSWQCHSKATSDFAFITSSSLVATSGHSNDNRNVCLWDTLISPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGYICIFDIRQRQLIHTFQAHDSAIKALALDSCEEYFTTGSAEGNIKVWRLTGHGLIHSFKSEHAKQSIFRNIGAGVMQIAISQDNRLFSCGADGTLKTRVLPSAFNIPNRILDIL