wanglab/gogpt-training-data huggingface dataset:
Protein: DENN domain containing 4C (A0A0A0MRX3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPSRTHKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKMWVAVASAYSYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPRYQRVQRPLYVVINGVPL
Protein: EF-hand calcium-binding domain-containing protein 11 (Q9BUY7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFFSEARARSRTWEASPSEHRKWVEVFKACDEDHKGYLSREDFKTAVVMLFGYKPSKIEVDSVMSSINPNTSGILLEGFLNIVRKKKEAQRYRNEVRHIFTAFDTYYRGFLTLEDFKKAFRQVAPKLPERTVLEVFREVDRDSDGHVSFRDFEYALNYGQKEA
Protein: Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (SET domain bifurcated 2) (A0A087WYZ9)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGKKPSDAKTFWMELEDDGKVDFIFEQVQNVLQSLKQKIKDGSATNKEYIQAMILVNEATIINSSTSIKGASQKEVNAQSSDPMPVTQKEQENKSNAFPSTSCENSFPEDCTFLTTENKEILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKMPLNLKGENPLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDENTMKNIFSKKRKLEVACSDCEVEVLPLGLETHPRTAKTEKCPPKFSNNPKELTVETKYDNISRIQYHSVIRDPESKTAIFQHNGKKMEFVSSESVTPEDNDGFKPPREHLNSKTKGAQKDSSSNHVDEFEDNLLIESDVIDITKYREETPPRSRCNQATTLDNQNIKKAIEVQIQKPQEGRSTACQRQQVFCDEELLSETKNTSSDSLTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL
Protein: Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) (P63097)
Organism: Bos taurus (Bovine)
Function: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (By similarity). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P10824}. Cytoplasm {ECO:0000250|UniProtKB:P10824}. Cell membrane {ECO:0000250|UniProtKB:P10824}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10824}; Cytoplasmic side {ECO:0000250|UniProtKB:P10824}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P10824}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P63096}. Membrane {ECO:0000250|UniProtKB:P10824}; Lipid-anchor {ECO:0000250|UniProtKB:P10824}. Note=Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane. {ECO:0000250|UniProtKB:P10824}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Rhodopsin
- Lysophosphatidic acid receptor 1
- Guanine nucleotide-binding protein G
- D
- Mu-type opioid receptor
- S1PR3 protein
- Prostaglandin E2 receptor EP3 subtype
- Sphingosine 1-phosphate receptor 5
- Mitogen-activated protein kinase
Sequence:
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Protein: Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Q9D2N4)
Organism: Mus musculus (Mouse)
Function: Involved in synapse maturation and required for normal muscle function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14623885}. Synapse {ECO:0000269|PubMed:14623885}. Cell membrane {ECO:0000269|PubMed:14623885}. Note=In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane.
Interaction partners:
- Dystrophin
- Dystroglycan 1
- Sarcospan
- Alpha-1-syntrophin
- Alpha-sarcoglycan
- Beta-1-syntrophin
- Gamma-sarcoglycan
- Delta-sarcoglycan
- Beta-sarcoglycan
- Utrophin
Sequence:
MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNIELNVARLEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSHSNQHQMKEYTSWKSPAKKLTNALSKSLSCASSREPLHPMFPDQPEKPLNLAHIVPPRPVTSMNDTLFSHSVPSSGSPFITRSSPPKDSEVEQNKMLARAAPAFLKGRGIQYSLNVADRLADEHVLIGLYVNMLRNDPPCMLESSNRLDEEHRLIARYAARLAAESSSSQPTQQRSAPDISFTIDANKQQRQLIAELENKNREILQEIQRLRVEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKEEELKQGTQGASSPRSSPSHTISRPIPMPIRSASACPTPTHTPQDSLTGVGGDVQEAFAQSSRRNLRSDLLVAADSITNTMSSLVKELNSEVASETESTVDSEFSRPQFEDLAPSPTSEKAFLAQIHSRKPGYIHGGAASTTHGDMVPEDGDPYTQPEDGNYENESVRQLENELQLEEYLKQKLQDEAYQVSLQG
Protein: Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] (O15240)
Organism: Homo sapiens (Human)
Function: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity).
Subcellular location: [Neurosecretory protein VGF]: Secreted {ECO:0000269|PubMed:19194657}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:19194657}. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
Interaction partners:
- Early growth response protein 1
- Neurotrophic factor BDNF precursor form
- RE1-silencing transcription factor
- Secretogranin-2
- Beta-nerve growth factor
Sequence:
MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENYIEHVLLRRP
Protein: Apoptosis-inducing factor 1 (EC 1.-.-.-) (Q10499)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Putative FAD-dependent oxidoreductase involved in the resistance to cercosporin and other singlet oxygen-generating photosensitizers. Translocates from mitochondria to the nucleus under apoptotic conditions, where it degrades DNA and induces apoptosis (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates from mitochondrion to the nucleus upon apoptosis induction. {ECO:0000250}.
Interaction partners:
- Heme A synthase-mitochondrial ferredoxin fusion protein
- Cytochrome c oxidase subunit 7
- Small ribosomal subunit protein uS13m
- ATP phosphoribosyltransferase
- Glutathione reductase
- Small ribosomal subunit protein uS5m
- Putative glycine dehydrogenase
Sequence:
MLLRFFINQPRFIQFTFLRNKKDRILGLQLGKQPFRMSSSSGLKQQGLAQKKKFQLEFDPSSVSKNGTKTEAKVVGTEFGVLLVRARNTYFATAGKCSHYGAPLAKGVVTSDGHIVCPWHGACFNAATGDVEDTPAIAALRTFPVTEEGDGSLWIEVEDKNDNGASVLQPEGCWRNKATEVYNKGSVETEVTAPHVCIIGGGKGASVAAEYLREKNFKGKITIFTREDEVPYDRPKLSKSLLHDISKLALRSKEYYDDLDISFHFNTDVTKIDLAEKKIYCGSDEKPTESYTKLILATGGEPNKLPIPGLDSKNVYLLRSIADASKLAAVTTEAGDKKNIVIIGSSFIGLELAVVLKDHNVSVIGMESIPFEKVMGKEVGTALKALHEQNGIAFYLENSIKEVKTSSNDSSKAEHIVLKDGQSIPADVVILAAGVKPNLRYLGNAVSLEKDGGVKVDEHCRVLGAEDVYAVGDIAHAPFAGLPSSGEKSHTRIEHWDVAGNLGRVAADHILFGNKAGYTTKSFTPYFWSAQGKQLRYCGNNAAEGFDDVVIQGSLSDYKFACFFTKGEKVVGVCSIMKDPVVSQCARLFIKDAMPSKSQLKENFDVLSIPL
Protein: Uncharacterized protein (Q38AI8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGQGLTGGAMAGAALSITALPLRLTLADHLGICGAATACGLALDFASDCCSKEGRVIIHRDVLLKAQDPLRHLSTFYTTCESNRMARLFRQKHEWVVLESHGQQYYVVQKNPATGDVLMDVRNSLRAANDVGLQVAGKPMHTGEIRQHRMETEFDLPSDLQVAYVIAWLRKEDPRWAFSTENSRQFTARVRYALMDF
Protein: Protein FRIABLE 1 (EC 2.4.1.-) (O-fucosyltransferase 33) (O-FucT-33) (O-fucosyltransferase family protein) (Q9LFC6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glycosyltransferase required for normal cell adhesion and cell wall integrity.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:22916179}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Galacturonosyltransferase 8
- Fucosyltransferase
- Protein FAR1-RELATED SEQUENCE 12
- Probable pectin methyltransferase QUA2
- Protein FAR1-RELATED SEQUENCE 7
- Protein FAR1-RELATED SEQUENCE 9
- Formin-like protein 20
- Protein FAR1-RELATED SEQUENCE 8
- Probable pectin methylesterase CGR2
- AT-hook motif nuclear-localized protein 14
Sequence:
MSVGVPVNPSSSSQLPAAPTTTTRRRVADSQEDHSHVNTVGGGNAVVYVPDEEETATSCCGGGGGGGSLSCCPSGSHHNYLVGFLSLRKFRLVWMLMVENKSKWTAGIARNMRSTTNLGRFILTLLSILVVTFFLIVALSGGVGRRRKHVEKHEFVVSIHPRPTIEKIIREDESSNSFQVLVPKTTSIPEIWNQPEVGNYQKCVARPKNQRPIKQTNGYLLVHANGGLNQMRTGICDMVAIAKIMNATLVLPFLDHSSFWSDPSSFKDIFDWKHFIKVLAEDVNIVEYLPQEFASIKPLEKNPVSWSKSSYYRNSISKLLKKHKVIVFNHTDSRLANNSPPPSIQRLRCRANYEALRYSEDIENLSNVLSSRLRENNEPYLALHLRYEKDMLAFTGCNHSLSNEESIDLEKMRFSIPHWKEKVINGTERRLEGNCPMTPREAAVFLKAMGFPSTTNIYIVAGKIYGQNSMTAFHEEFPNVFFHNTLATEEELSTIKPYQNRLAALDYNLALESDIFAYTYDGNMAKAVQGHRRFEGFRKTINPDRQRFVRLIDRLDAGLISWEDFSSKVKKMHQHRIGAPYLRQPGKAGMSPKLEENFYANPLPGCVCDTSEEQTGLNRFERPSLRAQSLR
Protein: Non-reducing end alpha-L-arabinofuranosidase BoGH43B (EC 3.2.1.55) (Glycosyl hydrolase family protein 43B) (BoGH43B) (A7LXU0)
Organism: Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153)
Function: Alpha-L-arabinofuranosidase involved in xyloglucan degradation by mediating the cleavage of terminal non-reducing alpha-L-arabinofuranoside residues in xyloglucan branches, converting the 'S' units to 'X' units.
Subcellular location: Periplasm {ECO:0000305}. Note=Periplasmic localization is predicted by analogy with the archetypal sus locus. {ECO:0000269|PubMed:24463512}.
Interaction partners:
Sequence:
MMKNSCRLLLILIGLWMANVSLAQKTFRNPIITGMNPDPSICRVGDDFYLVTSTFEYFPGLPVYHSKDLVHWKLIGHALSRPENNPLMGCNASTGGQYAPTLRYHDGTFYVIGTNYGGKGSQGVFYVTAKNPAGPWSDPVWVGNWYVDPSIEFIDGKMYFLSPDNQGSFLLGVMDPETGTFVEALRKVASGLGGSSPEGPHFYKIGDYYYIMSAEGGTGYEHREVIQRSKSPWGPYEPSPVNPVLSNMNCPDHPFQAIGHADLVQLKDGSWWAVCLGIRPVNGKYQHLGRETFLAPVTWDADGWPKVGKDGVVQETYLFPNLPSHVWMEQPVRDDFDQETLGLDWTFIRNPAHSFWSLTEKPGSLRLKGTAINFTTNDSPSFIGRRQAAFNLTASAKVNFIPKVENEEAGLVVRADDKNHYDLLITERNGQRVAMIRKTLKDKVVDTTCKELPATGEVILSITATETTYTFEIKAAHVSAILGTASTRDVSNEVVGGFTGVFIGMYASGNGQANTNPADFDWFDFRCLD
Protein: Origin recognition complex subunit 4 (C9JGH7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDK
Protein: Response regulator mcs4 (Mitotic catastrophe suppressor 4) (P87323)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Response regulator that coordinately controls the stress activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell cycle.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Multistep phosphorelay regulator 1
- MAP kinase kinase kinase wis4
- MAP kinase kinase kinase win1
- Protein kinase wis1
- Mitogen-activated protein kinase sty1
- Glyceraldehyde-3-phosphate dehydrogenase 1
- Peroxide stress-activated histidine kinase mak3
- Protein kinase byr1
- Protein kinase byr2
- Transcription factor prr1
Sequence:
MRIWFKKVPDGITSSVILSEDHLVDDLKDAIARKFPIRISQYYDAPELSIRVVAPPNASSELQSRELSPNESILFVMETYYPHGQDFNDALLVASPDTSVALRYRSSQLSSSTFESTPPVFSEYPPNIIPTPANETVPRIKQPSIALDSLESPVSAPSRHQSTYSYKGGPLNYNLRNASRTRSHQTLPSSNVNKTGVLLLPRSSRQQTLASRPSLPDLTSADKSQPSDEAESITRKNSIGMSTRSDESTAEKLAKAEVATPTNSRSISHSSLYTKQSGTAGVLPAVNADIDAANRMNPDISSQFPIADNKDPLNADTQAHLGFPSNQIDGIVGTSPVNVLTSPGIGAKAPFASLLEGVIPPINVLIVEDNIINQKILETFMKKRNISSEVAKDGLEALEKWKKKSFHLILMDIQLPTMSGIEVTQEIRRLERLNAIGVGAPKLTQPIPEKDQLNENKFQSPVIIVALTASSLMADRNEALAAGCNDFLTKPVSLVWLEKKITEWGCMQALIDWNGWCRFRGR
Protein: Geraniol dehydrogenase (GeDH) (EC 1.1.1.347) (Geraniol oxidation pathway protein A) (Perillyl-alcohol dehydrogenase) (EC 1.1.1.144) (H1ZV38)
Organism: Castellaniella defragrans (strain DSM 12143 / CCUG 39792 / 65Phen) (Alcaligenes defragrans)
Function: Catalyzes the NAD(+)-dependent oxidation of geraniol to geranial. Is involved in the anaerobic degradation of the monoterpene beta-myrcene. Can also catalyze the oxidation of (S)-perillyl alcohol to perillyl aldehyde, and to a lesser extent, the oxidation of nerol, citronellol, cumic alcohol, and benzyl alcohol. Cannot use NADP(+) instead of NAD(+) as cosubstrate.
Interaction partners:
Sequence:
MNDTQDFISAQAAVLRQVGGPLAVEPVRISMPKGDEVLIRIAGVGVCHTDLVCRDGFPVPLPIVLGHEGSGTVEAVGEQVRTLKPGDRVVLSFNSCGHCGNCHDGHPSNCLQMLPLNFGGAQRVDGGQVLDGAGHPVQSMFFGQSSFGTHAVAREINAVKVGDDLPLELLGPLGCGIQTGAGAAINSLGIGPGQSLAIFGGGGVGLSALLGARAVGADRVVVIEPNAARRALALELGASHALDPHAEGDLVAAIKAATGGGATHSLDTTGLPPVIGSAIACTLPGGTVGMVGLPAPDAPVPATLLDLLSKSVTLRPITEGDADPQRFIPRMLDFHRAGKFPFDRLITRYRFDQINEALHATEKGEAIKPVLVF
Protein: Probable oxalyl-CoA decarboxylase OxcA (O53639)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Putative acetolactate synthase small subunit
- Probable fatty-acid-CoA ligase FadD7
- Ketol-acid reductoisomerase
- Dihydroxy-acid dehydratase
- 2-isopropylmalate synthase
Sequence:
MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARAAQASGIRYIGFRHEASAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTNCFPMIQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTATSGRPGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQRPLLVLSKGAAYAQADNVIREFVEHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARADVVLLVGARLNWLLGNGESPQWSADAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSALLEAAADRSSVASAAWTGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVNEGANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAIEGDSAFGFSGMEFETICRYRLPVTVVILNNGGVYRGDEATIFRSAAPVWRHDPAPTVLNAHARHELIAEAFGGKGYHVSTPTELESALTDALASNGPSLIDCELDPADGVESGHLAKLNTTSAATPAISGDG
Protein: Proteasome subunit beta type-7 (Macropain subunit PRE4) (Multicatalytic endopeptidase complex subunit PRE4) (Proteasome component PRE4) (Proteinase YSCE subunit PRE4) (P30657)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. PRE3 and PRE4 are necessary for the peptidyl-glutamyl-peptide-hydrolyzing activity.
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809, ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 26S proteasome regulatory subunit RPN8
- Proteasome subunit alpha type-4
- 26S proteasome subunit RPT4
- Proteasome activator BLM10
- Proteasome subunit beta type-4
- 26S proteasome regulatory subunit RPN5
- 26S proteasome regulatory subunit RPN3
- Proteasome subunit beta type-6
- 26S proteasome regulatory subunit RPN12
- 26S proteasome regulatory subunit RPN6
Sequence:
MNHDPFSWGRPADSTYGAYNTQIANAGASPMVNTQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAIIDKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI
Protein: Uncharacterized protein (Q9AAH3)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- Uncharacterized protein
Sequence:
MGLGMSANAAPSARYPTSKWPVRADLITLRVCADLDWRVTVRCPHCGIARQLFGPELAARKLADVPLYKLFERGAFKCRKAQYGCNGVPASEISVDAMDVGQLQNVACWSR
Protein: Ketol-acid reductoisomerase, chloroplastic (EC 1.1.1.86) (Acetohydroxy-acid reductoisomerase) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Q01292)
Organism: Spinacia oleracea (Spinach)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:1713446}.
Interaction partners:
Sequence:
MAATAATTFSLSSSSSTSAAASKALKQSPKPSALNLGFLGSSSTIKACRSLKAARVLPSGANGGGSALSAQMVSAPSINTPSATTFDFDSSVFKKEKVTLSGHDEYIVRGGRNLFPLLPDAFKGIKQIGVIGWGSQAPAQAQNLKDSLTEAKSDVVVKIGLRKGSNSFAEARAAGFSEENGTLGDMWETISGSDLVLLLISDSAQADNYEKVFSHMKPNSILGLSHGFLLGHLQSLGQDFPKNISVIAVCPKGMGPSVRRLYVQGKEVNGAGINSSFAVHQDVDGRATDVALGWSIALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVECLFRRYTESGMSEDLAYKNTVECITGVISKTISTKGMLALYNSLSEEGKKDFQAAYSASYYPSMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGKIDQTRMWKVGEKVRSVRPAGDLGPLYPFTAGVYVALMMAQIEILRKKGHSYSEIINESVIEAVDSLNPFMHARGVSFMVDNCSTTARLGSRKWAPRFDYILSQQALVAVDNGAPINQDLISNFLSDPVHEAIGVCAQLRPSVDISVTADADFVRPELRQA
Protein: MAGUK p55 scaffold protein 7 (U5GXS2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVA
Protein: Protein Wnt-5b (Q92050)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. Regulates convergent extension movements and hypaxial myogenesis during gastrulation via activation of non-canonical Wnt signaling.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P41221}. Secreted {ECO:0000250|UniProtKB:P41221}.
Interaction partners:
- Frizzled class receptor 2
- Tyrosine-protein kinase RYK
- Frizzled-5
- Receptor tyrosine kinase-like orphan receptor 2
- Frizzled-4
- Frizzled-3
- Catenin beta-1
- Low density lipoprotein receptor-related protein 5
- Secreted frizzled-related protein 5.
- Frizzled class receptor 7a
Sequence:
MDVRMNQGHLLLAVTLIVCNSQLLVVANSWWSLAMNPIQRPEMYIIGAQPLCSQLTGLSQGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVDNTSVFGRVMHIGSRETAFTYAVSAAGVVNAVSRACREGELSTCGCSRAARPRDLPRDWLWGGCGDNVNYGYRFAREFVDAREREKNYPRGSVEHARTLMNLQNNEAGRMAVYNLANVACKCHGVSGSCSLKTCWLQLADFRRVGEFLKEKYDSAAAMRINRRGKLELVNNRFNPPTGEDLVYIDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTYKHERCHCKFHWCCYVKCKRCTSLVDQFVCK
Protein: Flap endonuclease GEN (EC 3.1.-.-) (Flap structure-specific endonuclease GEN) (Xpg-like endonuclease) (DmGEN) (Q9VRJ0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded. Also possesses weak 5'- to 3'-exonuclease activity on nicked but not gapped double-stranded DNA. Does not cleave bubble-like or Holliday junction substrates.
Subcellular location: Nucleus {ECO:0000269|PubMed:17614965}.
Interaction partners:
- DNA polymerase delta catalytic subunit
- Exonuclease 1
- Proliferating cell nuclear antigen
- Proliferating cell nuclear antigen 2
- Crossover junction endonuclease MUS81
- DNA ligase 1
- DNA replication ATP-dependent helicase/nuclease
- Tumor necrosis factor receptor superfamily member wgn
- RecQ-like DNA helicase Blm
- Double-strand break repair protein
Sequence:
MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWVCESLNVVDYFVHPRHHLKNLFFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQGAQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETEILDRMRSWRGETDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWKEQRLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQIGHLLQWPEIYCFQKFFPILTRWQVQQSKQEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQIAEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKENEPNSKPKRVVRKIKAQPEENQPLLHQFLGRKKEGTPVKAPAPQRQQCSTPITKFLPSDLESDCDAEEFDMSDIVKGIISNPNAKPALTNHDGHQLHYEPMAEDLSLRLAQMSLGNVNESPKVETKRDLSQVDQLPQSKRFSLEDSFDLLVKGDLQKLARTPVERFKMQHRISEKIPTPVKPLDNISYFFNQSSDNADVFEELMNSSLVPQDQEDNAEDEEEDDLVVISD
Protein: Smad nuclear interacting protein 1 (cDNA, FLJ96650, Homo sapiens Smad nuclear interacting protein (SNIP1), mRNA) (B1AK66)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKAVKSERERGSRRRHRDGDVVLPAGVVVKQERLSPEVAPPAHRRPDHSGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHSTVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEEEREFYNARRREHRQRNDVGGGGSESQELVPRPGGNNKEKEVPAKEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSEIDRKDDEDEEEEEEVSDS
Protein: Hyaluronan and proteoglycan link protein 3 (Q96S86)
Organism: Homo sapiens (Human)
Function: May function in hyaluronic acid binding.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
Sequence:
MGLLLLVPLLLLPGSYGLPFYNGFYYSNSANDQNLGNGHGKDLLNGVKLVVETPEETLFTYQGASVILPCRYRYEPALVSPRRVRVKWWKLSENGAPEKDVLVAIGLRHRSFGDYQGRVHLRQDKEHDVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVFPYQSPNGRYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGGPGLAPGVRSYGPRHRRLHRYDVFCFATALKGRVYYLEHPEKLTLTEAREACQEDDATIAKVGQLFAAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSFGFPDPQSRLYGVYCYRQH
Protein: Myosin regulatory light chain MRCL3 variant (Q53HL1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSSKRTKTKTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRNGFIDKEDLHDMLASLGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
Protein: Ribosome biogenesis regulatory protein (Q5B6T5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364132}.
Interaction partners:
- Ribosome production factor 2 homolog
- Ribosomal biogenesis protein Gar2
- rRNA processing protein
- rRNA-processing protein cgrA
- Nucleolar GTP-binding protein 1
- Ribosome assembly factor mrt4
- Nucleolar GTP-binding protein 2
- Ribosomal protein L1
- 60S ribosome subunit biogenesis protein NIP7
- Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein
Sequence:
MANSETEAKSTIKPKPERLPITVSKPTPYTFDLGHLLANDPNPLELPKSEPLNASLKATARDGVQSLLNQLLTTCPITSSQQGVLLTLPAPSTILPRHKPLPTPKPPTKWELFARKKGIGKYSNKPGAALADKERRKKLVYDEESGEWVPRWGYKGKNKDDDQWLVEVKEKDWKKEEEAAAKGSSIRGMSRAERKERIRRNERKMRANERNSRKSGGK