wanglab/gogpt-training-data huggingface dataset:
Protein: Glucuronokinase 1 (AtGlcAK1) (EC 2.7.1.43) (Q93ZC9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sugar-1-kinase with a strict substrate specificity for D-glucuronic acid and ATP. Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in a salvage pathway for glucuronic acid.
Interaction partners:
- UDP-sugar pyrophosphorylase
- Galacturonokinase
- Inositol oxygenase 4
- Inositol oxygenase 1
- Inositol oxygenase 5
- Inositol oxygenase 2
- L-arabinokinase
- Probable glucuronokinase 2
- Aldo-keto reductase family 4 member C10
- Mevalonate/galactokinase family protein
Sequence:
MDPNSTVSGDGQATAAIEHRSFARIGFLGNPSDVYFGRTISLTIGNFWASVKLEPSEHLVIKPHPFHDLVQFTSLDHLLNRLQNEGYYGGVRLLMAICKVFRNYCKENDIQLHQANFSLSYDTNIPRQTGLSGSSAIVSAALNCLLDFYNVRHLIKVQVRPNIVLSAEKELGIVAGLQDRVAQVYGGLVHMDFSKEHMDKLGHGIYTPMDISLLPPLHLIYAENPSDSGKVHSMVRQRWLDGDEFIISSMKEVGSLAEEGRTALLNKDHSKLVELMNLNFDIRRRMFGDECLGAMNIEMVEVARRVGAASKFTGSGGAVVVFCPEGPSQVKLLEEECRKAGFTLQPVKIAPSCLNDSDIQTL
Protein: Caerin 2.1 (P86485)
Organism: Litoria peronii (Emerald spotted tree frog) (Hyla peronii)
Function: Antibacterial peptide with narrow spectrum of activity. Active against the Gram-negative bacterium P.multocida (MIC=25 ug/ml). Inhibits the formation of NO by neuronal nitric oxide synthase with an IC(50) of 9 ug/ml.
Subcellular location: Secreted {ECO:0000269|PubMed:19642086}.
Interaction partners:
Sequence:
GLVSSIGRALGGLLADVVKSKGQPA
Protein: Signal transduction histidine-protein kinase ArlS (EC 2.7.13.3) (Q9KJN3)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR. ArlS/ArlR affects expression of the multidrug resistance transporter norA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (serine protease), spa (surface protein A) and hla (alpha-hemolysin). Could inhibit biofilm development by a mechanism independent of the presence of the poly-N-acetylglucosamine (PNAG). Also, Arl proteins are required for the efficient activity of DNA gyrase inhibitors and high osmolarity on spa expression.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Response regulator ArlR
- Heme response regulator HssR
- Transcriptional regulatory protein WalR
- Response regulator SaeR
- Transcriptional regulatory protein SrrA
- Two-component response regulator, putative
- Transcriptional regulatory protein KdpE
- Response regulator protein GraR
- DNA-binding response regulator, putative
- 2-oxoglutarate dehydrogenase E1 component
Sequence:
MTKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKPVKDISALDLNASLGNFQEIIIYDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGIEYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALAFGVIATIITATISYVFSTQITKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDASHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMNRIIKLVEELLELTKGDVNDISSEAQTVHINDEIRSRIHSLKQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAIKYDVKNKKIKVKTRLKNKQKIIEITDHGIGIPEEDQDFIFDRFYRVDKSRSRSQGGNGLGLSIAQKIIQLNGGSIKIKSEINKGTTFKIIF
Protein: Zinc finger protein weckle (Q9VIS9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAAQVEMHAAPAAPHVDRNPSSDWRQWCRLCAKDDVQGNLNVFLKNEDSGEAASMELATAIGKYFWVNITRGEELPETICSECLSLVTSLVNFSERITRVQKLYCILQSTPSQERPNLHELRSKFGLLDEETQTEVHYVDKKPKLDEQLEFLPEESPYELANPLTPEEKQESVDQEQDQPTEEPDEQDADYEPNEDRVLMSLCDVYGIQEDNSSAGSLDGSSPSTEKAGEDAADSEKRHQCNECLRSYATSKTLQRHLRQDHGQTEPTTEQLQCPDCPKKFRLHYQLERHMKWHVPLPKRKQYACSSCDKKFATSASAQQHEQYMHLDERPRPVICEQCGVGVHSMSALKEHVLKHTDYAPFECEVCKKCFKSANRLKHHKETHDPHKYICPECGMQLNSRTTLNRHRLVHTDQMQHKCDYCGREFKRAKALKNHLILHTGLKPYSCDFCDRTFANGSNCRTHKKKSHPEELAAQEAAGGGRSHNRNIPKLEALKAFTKNKDNLSPVATKQSGCFAFGKKPRPATKDTPASNPAVIQDAQPEPAPDPGGENATQADTPAAAIPTLDNIYNHIMIDYR
Protein: Doublesex- and mab-3-related transcription factor A2 (Doublesex- and mab-3-related transcription factor 5) (A2A9A2)
Organism: Mus musculus (Mouse)
Function: May be involved in sexual development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
Sequence:
MELRSELPSVPGAATAAATATGPPVASVASVAAAAAAAASLPVSVAGGLLRAPPLLLRAAEKYPRTPKCARCRNHGVVSALKGHKRYCRWKDCLCAKCTLIAERQRVMAAQVALRRQQAQEENEARELQLLYGTAEGLALAAANGIIPPRPAYEVFGSVCATDGGGPGAGAPAGSAGGAGGAEAKLQKFDLFPKTLLQAGRPDSPQPPPGKPLSPDGADSGPRTSSPEVRPGSGSENGDGESFSGSPLARASKEAGGSCPGSAGAGGGGEEDSPGSSSPLGSESGSEADKEEAEAAPTPGLGGGPGPRQRTPLDILTRVFPGHRRGVLELVLQGCGGDVVQAIEQVLNHHRGGLAAGLGPAAPLEKAAVSAAVEDAWPGRVEAAAAGGAGLPAPLQTGPTAPPHHRPLLAGAMTPGALGSLSSRSAFSPLQPNASHFGADAGAYPLGAPLGLSPLRLAYSAAAAHSRGLAFMAPYSTAGLVPTLGFRPPMDYAFSDLMRDRSAAAAAAVHKEPGYGGGLYGPMVNGTPEKQ
Protein: Inner kinetochore subunit cnl2 (Centromere-localized protein 2) (Constitutive centromere-associated network protein cnl2) (O13952)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular location: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localized at the central region, but not at the outer repeats, of the centromere and remains at the centromere during mitosis and meiosis.
Interaction partners:
- Inner kinetochore subunit fta7
- Inner kinetochore subunit fta4
- Inner kinetochore subunit fta6
- Inner kinetochore subunit mal2
- Kinetochore protein mis13
- Inner kinetochore subunit fta2
- Inner kinetochore subunit mis6
- Inner kinetochore subunit mis17
- Inner kinetochore subunit fta1
- Inner kinetochore subunit fta3
Sequence:
MNMEEQILNDYLLSQGRLQSIISLEQWRQLFPQRYREDPLIERLYEYCTQQRQKRLAKLRANIHLESQVIGKSRIDRMLATNVEKLQTVSHASTLHDVEEFYTSHSAKPLDISEINERLSEAVQSAYTKLNEEKERCTQLTLKMNSQIASLSDFQWSKEPNVDESIHLVESLIESLEKAAPSAIEELD
Protein: LD30467p (Motif 1 binding protein) (Q9VHM3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Boundary element associated factor
- TATA box-binding protein-like 1
- Homeobox protein abdominal-A
Sequence:
MSKSALKHLKSTCRVCAKYASNKRSPKLFERSNTKMIDNIEALTGLRLENYGCLPDQICECCSMELASAVKLRERCIAAQRELLLGLTEEQRQGISAFYRAAVMGEDIVQTVKTPDDDEVYATYQEIVLEEPKEEIDDTKVEYDNTYYEVAEGHAGEDDAASLIEEADYDSIMAEDEEQQQTLELDEDTELIVGDVNDAYVYDSDDEVAVLDNVLDDEYEHENIVVKKCSLPPKPKVRSDDARRRGTGGVYICEQCGNHIKGRMAFELHCRRHRGDKQFGCELCQSRFCTTSELKRHMRKHTGERPFACKYCGRCFTDYTTRVKHERTHTNERPYVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLSTHFRSGVHKRHLEKAEMKQVLEQEQKRELKEEEEDSLHI
Protein: At1g44890 (Inner membrane OXA1-like protein) (Q6ICW9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein mL45
- F9K20.24 protein
- AT2G34250 protein
- SecY protein transport family protein
Sequence:
MSLVRCLSLRSVLNPQRYRSSYSFLIHLQNPREEEEPTHKTRSYHSIIHQNSLIGASSTAFSRYRSVFQSPATISSDRFISTFNFSGSGDAVIDWLLQSVVSRSYELHNVADVLVSLNHLLALLNSFTFSQWWVFIIVASLLIRGITVPVMVDMLNNIAKFFKSLRSNQGEVLDKVSFLNKSRGVMYTMLEKEFFGVKGSVIGQGIQVPIFWFSMGELKQNMVEILMSRLRGKILSAELIKNGVLSRGRLVVVVGDGFGIEIQMFDLDFSLILRRRQVSQS
Protein: PPE family protein PPE10 (P9WI41)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Plays a major role in the integrity and stability of the capsule.
Subcellular location: Secreted {ECO:0000269|PubMed:19602152}. Note=Secreted via the ESX-5 / type VII secretion system (T7SS). {ECO:0000269|PubMed:19602152}.
Interaction partners:
- Uncharacterized protein Rv0441c
- Methyltransferase type 12 domain-containing protein
- PE-PGRS family protein PE_PGRS30
- PE-PGRS family protein PE_PGRS28
- Uncharacterized protein Rv2209
- Probable membrane protein
- Uncharacterized protein Rv2082
- PE-PGRS family protein PE_PGRS15
- PE-PGRS family protein PE_PGRS43
- ESX-1 secretion-associated protein EspE
Sequence:
MTSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEELLASIASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAAAQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVEAAYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINLGFGNTGSGNIGNNNIGNNNIGSGNTGTGNIGSGNTGSGNLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSGTGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAGMQNAALGSAAGSEAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHGLANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGSGSAAAGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAVREPSTPGSGIPKSNFYPSPDRESAYASPRIGQPVGSE
Protein: 2'-5' oligoadenylate synthetase 1E (A0A0J9YV76)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MARELFRTPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMGGSYDEHNALKGRSEANMVVFFNDLTSFEDQLKWQQVFIEEIRKHLLQLQQEKPCKLKFEVQSSEEPNTRSLTFKLCSPERQQEVEFDVQPAYDALYEGGYCKSFESINYNKVYAQLIHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEFGVQDSFGLHAAQCFRTVLELVTKYKCLLIYWTWFYDFRPEISDYLHGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWIHSNFFRNCDMSLVNGWEVSLPTVFSGSQAVMDREERKLDFHLSTCWEVLSNSG
Protein: IP05687p (IP05787p) (Q4V653)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Phenoloxidase-activating factor 2
- Peptidase S1 domain-containing protein
Sequence:
MTPAIVLLTFLVILTLGSYGYSQLLDSKCIALFRIRVIGGQNARRTPWMAYLIRDNRFACGGSLIAYRFVLTAAHCTKINDNLFVRLGEYDSSRTTDGQTRSYRVVSIYRHKNYIDFRNHDIAVLKLDRQVVYDAYIRPICILLNSGLQSLANSIQNFTLTGWGQMAHYYKMPTTLQEMSLRRVRNEYCGVPSLSICCWNPVQYACFGDSGGPLGSLVKYGHKTIYVQFGVTNSVTGNCDGYSSYLDLMSYMPWLYQTLLRNWV
Protein: Modulator protein MzrA (P42615)
Organism: Escherichia coli (strain K12)
Function: Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00904, ECO:0000269|PubMed:19432797, ECO:0000269|PubMed:20889743}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00904, ECO:0000269|PubMed:19432797, ECO:0000269|PubMed:20889743}.
Interaction partners:
- Inner membrane protein YqjA
- Sensor histidine kinase EnvZ
Sequence:
MQIPRMSLRQLAWSGAVLLLVGTLLLAWSAVRQQESTLAIRAVHQGTTMPDGFSIWHHLDAHGIPFKSITPKNDTLLITFDSSDQSAAAKAVLDRTLPHGYIIAQQDNNSQAMQWLTRLRDNSHRFG
Protein: Large ribosomal subunit protein eL30z (Putative 60S ribosomal protein L30-1) (Q9C8F7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL21z/eL21y
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein eL42z/eL42y
- Small ribosomal subunit protein uS12y
- At1g43860
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein uS9x
- Small ribosomal subunit protein uS14z/uS14y/uS14x
Sequence:
MVAAKKTKKSHEGINSRLALVMKSGKYTLGYKSVLKSLRSSKGKLILISSNCPPLRRSEIEYYAMLAKVGVHHYNRNNVDLGTACGKYFRVSCLSIVDPGDSDIIKSLPGDQ
Protein: Geranyl-CoA carboxylase, alpha-subunit (Biotin-containing) (Q9HZV6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Geranyl-CoA carboxylase, beta-subunit
- Citronellyl-CoA dehydrogenase involved in catabolism of citronellol
- Isohexenylglutaconyl-CoA hydratase
- Probable pyruvate carboxylase
- Probable transcarboxylase subunit
- Short chain dehydrogenase involved in catabolism of citronellol
- Methylcrotonyl-CoA carboxylase, beta-subunit
- Expressed protein with apparent function in citronellol catabolism
- Peroxisomal trans-2-enoyl-CoA reductase
- Very-long chain acyl-CoA synthetase
Sequence:
MPSFNKILVANRGEIACRVLRTAHELGYRSVAVYSEADADTRHVQLADEAVCIGPAAVAQSYLNLEAILDAARRSGAEAIHPGYGFLSENAEFARACEAAGIVFIGPDAEAIHLMGSKRLSKIAMLAAGVPCIPGYEGAEQDDATLRREAERIGYPLMIKASAGGGGRGMRLVEEPGQLLEQLRTARSEALGAFGSAELILERAVLRPRHVEIQVFGDRHGNLLYLGERDCSVQRRHQKVIEEAPCPVLDADLRRAMGEAAVKAAASVNYVGAGTVEFLLGEDGRFYFLEMNTRLQVEHPVTELVTGQDLVAWQIRIAEGHPLPLRQEQVELRGHAIEVRLYAEDAGRGFLPQTGTVLRWDPELLPGVRIDHGLVEGQAVTPFYDPMLAKLIAYGATRDEARRKLIRALERCVLLGVDGNQRFLANLLAHPDFAAGEATTAFIGERFAEDPSLQPRQPGAEELALAAALLYQAGAEASAHQPGLAGWRSAAGAPWKIVLKHAEQRLEIGLEVLESGRRPRLLARLERREIAVRLLDCDGRWASAELDGIRRRHAYHLDGGRLWLYGHGGNLELLDVTHAGASAQVGASSGTLKAPMDGAIVEVLVGEGERVGKGQLLLVLEAMKMEHPLKAGVDGVVRRVQVGRGEQVRNRQVLVEVEADA
Protein: SCP-containing protein A (Q9VGQ3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- LD21421p
Sequence:
MAFTKVLQLILLAVVAISSAVDYCALPTCLDKHVACNNKGNFSENCPKDVREVKIEPHHKLILNLFNELRNNVAGGKIEGLPKAVRMAKMSWCEELSHLALLNVKTCESLPDKCRSTERFAYAGQNNALFQYSGAETEYTDAEIIKEEIENWFAERSNASPEILASFPEELPNKAVTKFTIAVAEKNTHVGCAAVRFSRDFYNHFVLTCNFATSNIVGQPVYTPGEKATTGCKNRYGAAYDYPNLCYAKEIYDNEKVIENTQTM
Protein: Disease resistance protein RPP5 (EC 3.2.2.6) (Protein RECOGNITION OF PERONOSPORA PARASITICA 5) (F4JNB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TIR-NB-LRR receptor-like protein that confers resistance to the pathogen Hyaloperonospora arabidopsis isolate Noco2 (downy mildew disease). Confers resistance to H.arabidopsis isolates Emoy2, Emwa1 and Noco2.
Interaction partners:
- Disease resistance protein RPP8
- Disease resistance protein RPP13
- RuvB-like protein 1
- Disease resistance protein RPM1
- Protein EDS1
- Beta-1,3-N-Acetylglucosaminyltransferase family protein
- Negative regulator of systemic acquired resistance SNI1
- Aspartate--tRNA ligase 1, cytoplasmic
- Cysteine and histidine-rich domain-containing protein RAR1
- Protein SGT1 homolog B
Sequence:
MAASSSSGRRRYDVFPSFSGVDVRKTFLSHLIEALDGKSINTFIDHGIERSRTIAPELISAIREARISIVIFSKNYASSTWCLNELVEIHKCFNDLGQMVIPVFYDVDPSEVRKQTGEFGKVFEKTCEVSKDKQPGDQKQRWVQALTDIANIAGEDLLNGPNEAHMVEKISNDVSNKLITRSKCFDDFVGIEAHIEAIKSVLCLESKEARMVGIWGQSGIGKSTIGRALFSQLSIQFPLRAFLTYKSTSGSDVSGMKLSWEKELLSEILGQKDIKIEHFGVVEQRLKHKKVLILLDDVDNLEFLKTLVGKAEWFGSGSRIIVITQDRQFLKAHDIDLVYEVKLPSQGLALTMLCRSAFGKDSPPDDFKELAFEVAKLAGHLPLGLNVLGSSLRRRGKKEWMEMMPRLRNGLNGDIMKTLRVSYDRLHQKDQDMFLCIACLFNGFEVSYVKDLLEDNVGLTMLSEKSLIRITPDGHIEMHNLLEKLGREIDRAKSKGNPGKRQFLTNFEDIHEVVTEKTGTETLLGIRLPFEEYFSTRPLLIDKESFKGMRNLQYLKIGDWSDGGQPQSLVYLPLKLRLLDWDDCPLKSLPSTFKAEYLVNLIMKYSKLEKLWEGTLPLGSLKKMNLLCSKNLKEIPDLSNARNLEELDLEGCESLVTLPSSIQNAIKLRKLHCSGVILIDLKSLEGMCNLEYLSVDCSRVEGTQGIVYFPSKLRLLLWNNCPLKRLHSNFKVEYLVKLRMENSDLEKLWDGTQPLGRLKQMFLRGSKYLKEIPDLSLAINLEEVDICKCESLVTFPSSMQNAIKLIYLDISDCKKLESFPTDLNLESLEYLNLTGCPNLRNFPAIKMGCSDVDFPEGRNEIVVEDCFWNKNLPAGLDYLDCLMRCMPCEFRPEYLVFLNVRCYKHEKLWEGIQSLGSLEEMDLSESENLTEIPDLSKATNLKHLYLNNCKSLVTLPSTIGNLQKLVRLEMKECTGLEVLPTDVNLSSLETLDLSGCSSLRTFPLISKSIKWLYLENTAIEEILDLSKATKLESLILNNCKSLVTLPSTIGNLQNLRRLYMKRCTGLEVLPTDVNLSSLGILDLSGCSSLRTFPLISTNIVWLYLENTAIGEVPCCIEDFTRLRVLLMYCCQRLKNISPNIFRLRSLMFADFTDCRGVIKALSDATVVATMEDSVSCVPLSENIEYTCERFWGELYGDGDWDLGTEYFSFRNCFKLDRDARELILRSCFKPVALPGGEIPKYFTYRAYGDSLTVTLPRSSLSQSFLRFKACLVVDPLSEGKGFYRYLEVNFGFNGKQYQKSFLEDEELEFCKTDHLFFCSFKFESEMTFNDVEFKFCCSNRIKECGVRLMYVSQETEYNQQTTRSKKRMRMTSGTSEEYINLAGDQIVADTGLAALNMELSLGEGEASSSTSLEGEALSVDYMITKEQDEDIPFLDPVSDGTWRSFYSAE
Protein: Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] (Q15078)
Organism: Homo sapiens (Human)
Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.
Subcellular location: [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane {ECO:0000305|PubMed:17671990}; Lipid-anchor {ECO:0000269|PubMed:18507738}; Cytoplasmic side {ECO:0000305}. Cell projection, neuron projection {ECO:0000269|PubMed:10604467}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. {ECO:0000269|PubMed:10604467}.; SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus {ECO:0000269|PubMed:18507738}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10604467}. Perikaryon {ECO:0000269|PubMed:10604467}. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions (PubMed:18507738). In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites (PubMed:18507738). {ECO:0000269|PubMed:18507738}.
Interaction partners:
- Cyclin-dependent kinase 5
- Microtubule-associated protein tau
- Calpain-1 catalytic subunit
- Calpain-2 catalytic subunit
- CDK5 regulatory subunit-associated protein 2
- M-phase inducer phosphatase 2
- CDK5 regulatory subunit-associated protein 3
- Cellular tumor antigen p53
- Early growth response protein 1
- Transcription factor Jun
Sequence:
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
Protein: Hsp70 family ATPase (Q5A397)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Endoplasmic reticulum chaperone BIP
- Heat shock protein SSA2
- Heat shock protein HSP70
- Small ribosomal subunit protein uS19
- Fgr32p
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL3
- Zuotin
- Hsp90 cochaperone
- 60S acidic ribosomal protein P0
Sequence:
MADGVFQGAIGIDLGTTYSCVATYDSAVEIIANEQGNRVTPSFVAFTSEERLIGDAAKNQAALNPKNTVFDAKRLIGRAFDDESVQKDIKSWPFKVVESNGQPLIEVEYLDETKTFSPQEISSMVLTKMKEIAEAKIGKKVEKAVVTVPAYFNDAQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLGAGKSEKERHVLIFDLGGGTFDVSLLNITGGVFTVKATAGDTHLGGQDFDTNLLEHFKKEFQKKTGNDISGDARALRRLRTACERAKRSLSSGTQTTVEIDSLFDGEDFSANITRARFEDINSALFKSTLEPVEQVLKDAKISKSQVDEVVLVGGSTRIPKVQKLLSDFFDGKQLEKSINPDEAVAYGAAVQGAILTGQSTNDDTKDLLLLDVIPLSLGVAMQGNVFAPVVPRNTTVPTIKRRTFTTVADHQTTVQFPVYQGERVNCTENTLLGEFDLKNIPPMQAGEPVLEAIFEVDANGILKVTAVEKSTGRSANITISNSIGRLSTEEIEKMISDAEKFKSSDDAFAKRHEQKQKLEAYVASVESTVTDPVLSAKLKKSAKDKIEAALSDALQTLEIEESSADDYRKAELALKRAVTKGMATR
Protein: Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase) (Q9BYC5)
Organism: Homo sapiens (Human)
Function: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.
Interaction partners:
- Alpha-mannosidase 2
- Alpha-mannosidase 2x
- Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- Beta-1,4-galactosyltransferase 1
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
- Beta-1,4-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 3
- Beta-1,4-N-acetylgalactosaminyltransferase 3
Sequence:
MRPWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHPDHSSRELSKILAKLERLKQQNEDLRRMAESLRIPEGPIDQGPAIGRVRVLEEQLVKAKEQIENYKKQTRNGLGKDHEILRRRIENGAKELWFFLQSELKKLKNLEGNELQRHADEFLLDLGHHERSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKAKKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESQNWRYATGGWETVFRPVSETCTDRSGISTGHWSGEVKDKNVQVVELPIVDSLHPRPPYLPLAVPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKHPVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLATDDPSLLKEAKTKYPNYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQTLHPDASANFHSLDDIYYFGGQNAHNQIAIYAHQPRTADEIPMEPGDIIGVAGNHWDGYSKGVNRKLGRTGLYPSYKVREKIETVKYPTYPEAEK
Protein: Histone-lysine N-methyltransferase (A4LBC2)
Organism: Caenorhabditis elegans
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein
- DNA-directed RNA polymerase II subunit RPB2
- Histone-lysine N-methyltransferase Suv4-20
- E3 ubiquitin-protein ligase bre-1
- RRM domain-containing protein
- Probable histone-lysine N-methyltransferase lin-59
Sequence:
MFQRKVVLPKKRTEMVQTRRKTAAAVQDGGAVKENKAKPPAPQTPTKRAKRGRPPKIKTDANTLNTPSTSSNLVDDKLLIESESQDSILTNEADSFLEKEVEEIEDSSDILPDKINSPEKPSVLVKRRSSTRLKVKTDEDEKDVPVNIEVAVLEEKSIQIEPTSPAHPEDPQPSTSSLPLVEPIEDIVEPNEPTSSADPPVSNIKDEDIKEEEPLIKKPASDESESMDIANSESGNDSDSSEADPRTIPSFSIPLPDTPPPNFAKRGEIHVDVDQKNSKQSGESQSPWERAREKSASNPLSSPTMSRPRIHFLHPAYQSFTNDSVSPLPPPPPEPAPAREKVENGGPTTFKMTFKKAANIPILKTSAFEQPSSPPPSSSVSSSISLSEVNSSTSIASESSPAKRSSNFDLTASNELPPPQMVELPKLSFFNMPPAVRSAEDDSAMTSEEPILLLRSPNSATPDDDALFLTTPPPPKMTESEIQALKVATEKVNQVIARREDSEKDVRHREDRDDYDRRRDDRDRRSRKTDSERNDQRGRQREDDERRAREREREVTKRHDREREEMRLQKQKDEERRKKDEEERIQKENDEKKQKEDEAKMEEEKKKIKEEEMKIPEFELISESKYLTRNANKKKTESLTCECHRTGGNCSDNTCVNRAMLTECPSSCQVKCKNQRFAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKTKYAADKKHKHHYLCDTGVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIKAGEEITFDYQFVNYGRDAQQCFCGSASCSGWIGQKPEEFSSDEDDDIVTTRHINMDEEEEEKLEGLDHLGNHERNEVIKDMLDDLVIRNKKHARKVITIASAMTDYSQRVDVIQEIFSSDTSVTVQKFYAKEGMATLMAEWLSEDDYSLDNLKLVQAILKALHTELFDSCAKNDRLLRDSTSRWVNAKMDEYVDIQVIADSLIACVEDPVQEYKDVCKVIEKGLVENFTRAKEMAYRLNQYWFNRSVSFKIPKKIRDPVPKDVPVRQEDATTSSQSHDNSSRTVSPNHRHHSSSYSNSCYQEREPSHIRFFNNGNDVHQYRFGGYHGNNYNDNYFSRRPNKDSYRDRRRFNGRRSRSRSRSVSPQNYKRRKLDEHDNNHRQRSPIRDRHTSPGGEKTPSSNNSGERNYKRLDIRGARIKTIKEDLEAAAAAAAAAAVPSEVQAYPHEHTAVHQSVYQMPGYESYGVYDPVNGVYMYPHPGAGYYPPAYPQQPIMLTMDTLPPNDRLGELYEKASIEQLAQRDAIVRQELELIRIQIERKTAQKEAIKAACRRANEEEAKRQEALAKTKYVWAIAKSEAGETYYYNKITKETQWTAPTPVQGLLEPACGASPDTTVVIADEITEEEQQAEVLEKPRVVKEEVIEPGSQSETQKESPEKVRVVVPKVEVERSPSPKSSRDREKDREKSREKDRERDRDRREGSKHRDSYHGHRNGSSSVSERRMREFKHELERSTRSAVRSRLQHQRDASSDKTTWLIKLIYREIFKRESAQSGFDYRFSENTDKKVKNYVKSYIDRKLESNDLWKEYSRP