wanglab/gogpt-training-data huggingface dataset:
Protein: nicotinamidase (EC 3.5.1.19) (Nicotinamide deamidase) (Q50575)
Organism: Mycobacterium tuberculosis
Interaction partners:
- Nucleoside hydrolase
- Small ribosomal subunit protein uS12
- Nucleoside hydrolase
- DNA topoisomerase
- Indolylacetylinositol arabinosyltransferase
- DNA gyrase subunit A
- Catalase-peroxidase
- DNA-directed RNA polymerase subunit beta
- Aspartate 1-decarboxylase
- Cytotoxin / haemolysin homologue TlyA
Sequence:
MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAEAADYHHVVATKDFHIDPGDHFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSAIEAVFYKGAYTGAYSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCVRQTAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASVELVCSS
Protein: FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) (P98174)
Organism: Homo sapiens (Human)
Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
Subcellular location: Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with membrane ruffles and lamellipodia. {ECO:0000250}.
Interaction partners:
- Cell division control protein 42 homolog
- FYVE, RhoGEF and PH domain-containing protein 3
- Guanine nucleotide-binding protein G
- Src substrate cortactin
- Drebrin-like protein
Sequence:
MHGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQFVGPSDTSLGAAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPGQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDKT
Protein: Protein RRP5 homolog (Apoptosis-linked gene 4 protein) (Programmed cell death protein 11) (Q6NS46)
Organism: Mus musculus (Mouse)
Function: Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- WD repeat-containing protein 46
- Periodic tryptophan protein 2 homolog
- HEAT repeat-containing protein 1
- BMS1 homolog, ribosome assembly protein
- KRR1 small subunit processome component homolog
- U3 small nucleolar RNA-associated protein 4 homolog
- Nucleolar protein 14
- Nucleolar complex protein 4 homolog
- Small ribosomal subunit protein uS17
- Bystin
Sequence:
MANLEESFPRGGTRKLHKSEKSSQQVVEQDNLFDVSTEEGPIKRKKSQKGPAKTKKLKIEKRKSIKSIKEKFEILSLESLCEGMRILGCVKEVSELELVVSLPNGLQGFVQVTEVCDAYTQKLNEQVAQEEPLEDLLRLPELFSPGMLVRCVVSSLDVTESGKKSVKLSVNPKRVNKVLSADALRPGMLLTGTVSSLEDHGYLVDIGVGGTRAFLSLKKAQEYIRQKNKGAKFKVGQYLTCVVEEVKSNGGVVSLSVEHSEVSSAFATEEQSWNLNNLLPGLLVKAQVQKVTQFGLQLNFLTFFKGLVDFMHLEPKKMGSYSSNQTVKACILCVHPRTRVVRLSLRPIFLHPGRPLTRISYQQLGAVLDDVPVQGFFKNAGAIFRLKDGVLAYARVSHLSDSKKAFNAEAFKPGSTHKCRIIDYSQMDELALLSLRKSIIAAPFLRYHDIKIGTVVKGTVLAIKPFGILVKVGEQIKGLVPSMHLADIMMKNPEKKYSPGDEVKCRVLLCDPEAKKLIMTLKKTLVTSKLSLITCYEGAKPGLQTHGVIIRVKDYGCIVKFYNDVQGLVPKHELSTQHIPDPETVFYTGQVVKVAVLSCEPSKERMLLSFRLLSDSRPKDPGVESSQKKTGAVRIGQLVDVKVLEKTKTGLEVAILPHNTPAFLPTPHLSDHAANGPLLHHWLQTGDTLHRVLCLSQSERHILLCRKPALVSTVEGGQDPKSLSEIQPGMLLIGFVKCIKEYGVFVQFPSGLSGLSPKTIMSDKFVTTPSEHFVEGQTVVAKVTNVDESKQRMLLSLRLSDCSLGDSASTSFLLLCQCLEELQGIRSLMSNQDSVLIQTLADMTPGMVLDAVVHEVLEDGSVVFSSDPVPDLVLRASRYHRAGQEVEPGQKKKVVVLHVDMLKLEVHVSLHQDLVNRKTRKLRKSSRHQGIVQHLEESFAVASLVETGHLVAFSLISHLNDTFHFDSEKLRVGQGVCLTLKTTEPGVTGLILAVEGPASKRTRMPVQRDSETVDDKGEEKEEEEEEEEKEEENLTVKSKKRHSLAIGDKVTGTIKAVKATHVVVTLADGFVGCIHASRILDDVPVGTSPTTTLKAGKKVTARVIGGRDVKTSKFLPISHPRFVLTILELSVRPSELKGSYSALNTHSESPVEKIRQYQAGQTVTCFFKKYNVMKKWLEVDIGPDIRGRIPLLLTSLSFKVLKHPDKKFQVGQAIEATVVDPDVPRAFLCLSLIGPYRLEEGEVAMGRVMKVVPNRGLTVSFPFGKIGKVSMFHLSDSYSEAPLEDFCPQKIVRCYILSTAHRVLALSLRSSRTNRETKNRIEDPEINSIEDVKEGQLLRGYVKCVLPSSVIIGLGPSVLGLAKYSHVSECVPPEKELYNGCLPEGKLVTAKVLRVNPMKNLIELSLLPSDTGRPDVFSPAPEPKQEERSGGAEEGQKRKEKNQKRREEKEEPQKSQRGGRGKRERQESESEQELVNKRPKKSGAAEEDDSGVEVYYREGEDEVGEPKLPPRGKQTKSTEVPRLHLSSGFLWDVGLDSLTPALPLREESSDSEDEQPHQAKKKKGKKERELEKQKAEKELSRIEEALMDPGRQPESADDFDRLVLSSPNSSILWLQYMAFHLQATEIEKARAVAERALKTISFREEQEKLNVWVALLNLENMYGSQESLTKVFERAVQYNEPLKVFLHLADIYTKSEKYKEAGELYNRMLKRFRQEKAVWIKYGAFVLGRSQAGASHRVLQRALECLPAKEHVDVIVKFAQLEFQLGDVERAKAIFENTLSTYPKRTDVWSVYIDMTIKHGSQTAVRDIFERVIHLSLAPKRMKFFFKRYLDYEKQHGTEKDVQAVKAKALEYVEAKSSALED
Protein: CRISPR system Cmr subunit Cmr5 (CRISPR type III-B/RAMP module-associated protein Cmr5) (Q8U1T0)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), formerly called psiRNA (prokaryotic silencing) in this organism. Part of the Cmr ribonucleoprotein complex which has divalent cation-dependent endoribonuclease activity specific for ssRNA complementary to the crRNA (target NRA), generating 5' hydroxy- and 3' phosphate or 2'-3' cyclic phosphate termini. Cmr4 is probably the subunit that cleaves target RNA. Cmr complex does not cleave ssDNA complementary to the crRNA. Cleavage of invading RNA is guided by the crRNA; substrate cleavage occurs a fixed distance (14 nt) from the 3' end of the crRNA. In vitro reconstitution shows Cmr1-2 and Cmr5 are not absolutely necessary for target cleavage.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19945378}.
Interaction partners:
- CRISPR system Cmr subunit Cmr2
- CRISPR system Cmr endoribonuclease Cmr4
- CRISPR system Cmr subunit Cmr6
- CRISPR system Cmr subunit Cmr1-1
- CRISPR system Cmr subunit Cmr3
- CRISPR system Cmr subunit Cmr1-2
- CRISPR-associated endonuclease Cas1
- TIGR01897 family CRISPR-associated protein
- Type I-B CRISPR-associated protein Cas7/Cst2/DevR
- CRISPR-associated helicase Cas3
Sequence:
MEVHMLSKDNKKSIRKTLEQRRGEYAYYVIKEVADLNDKQLEEKYASLVKKAPVMILSNGLLQTLAFLLAKAETSPEKANQILSRVNEYPPRFIEKLGNDKDEHLLLYLHIVYWLRENVDRNIDVKTLLSQDYSKVLWATKEAIALLNWMRRFAVAMLKEEGKENEGSS
Protein: Noelin (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) (Pancortin) (Q9IAK4)
Organism: Gallus gallus (Chicken)
Function: Contributes to the regulation of axonal growth (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube.
Subcellular location: Secreted {ECO:0000269|PubMed:10783240}. Synapse {ECO:0000250|UniProtKB:O88998}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O88998}. Cell projection, axon {ECO:0000250|UniProtKB:O88998}. Perikaryon {ECO:0000250|UniProtKB:O88998}.
Interaction partners:
- Uncharacterized protein.
- Kinase D interacting substrate 220.
Sequence:
MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLTAASGGTLDRSTGVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMRGLESKFKQVEESHKQHLARQFKAIKAKMEELRPLIPVLEEYKADAKLVLQFKEEVQNLTSVLNELQEEIGAYDYEELQNRVSNLEERLRACMQKLACGKLTGISDPITIKTSGSRFGSWMTDPLAPEGENKVWYMDSYHNNRFVREYKSMADFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKYQSHIIIRFDLKTETILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDENGLWAVYATNQNAGNIVISKLDPNTLQSLQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQILYNVTLFHVIRSDEL
Protein: Anti-sigma factor antagonist (Q9RD40)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Interaction partners:
- Regulatory protein
- protein-serine/threonine phosphatase
- protein-serine/threonine phosphatase
- protein-serine/threonine phosphatase
- protein-serine/threonine phosphatase
- Regulatory protein
- Regulatory protein
- protein-serine/threonine phosphatase
- PPM-type phosphatase domain-containing protein
Sequence:
MSVEAEVTVTVVDDVRIVRVAGDYDAVGAETLAHALALPAETGTSGTVVDLAKVTFADSSFLHTLLAAQYRHQTSGIPLVLAEVTPVLQRLLDLTDVTRAFTVAQTVPTATETVHARKSSTRRQ
Protein: Slr0924 protein (Q55386)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Tic20 family protein
- Sll1891 protein
- Slr0841 protein
- Sll0044 protein
- Slr1747 protein
- Slr1855 protein
- Slr1485 protein
- Slr0872 protein
- Sll0827 protein
Sequence:
MPWLQTFSFRRSPFSLARRHLKNKIFVKIKSIFLLSLLFEATATMKSLLRIGATLGLIGTTAIGTWLGTTLQALALPTEEVVKILQGVPVFTIVDAQGAPLVAVGNDNEKVTGVFISQQEANGFLQELKKQKPDVGSQVSVQPVSLGEVVKIAQANANQTDPLGFAYVPIPAQVQAAQQMPNSEYQGGVPLFVARGGEDQGYLTIQQENEQIIPFFLEASQIQQMVERFKQEQPAMADSIVIDVIAMENVISTLQTSDDAMLKQIRIVPTQEAIQFIRSLSAQQPK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (D4A6T9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Tubulin gamma-1 chain
- Gamma-tubulin complex component 6
- Biogenesis of lysosome-related organelles complex-1 subunit 2
- 3',5'-cyclic-AMP phosphodiesterase 4B
- Gamma-tubulin complex component
- Retroelement silencing factor 1
- E3 ubiquitin-protein ligase Topors
Sequence:
MSSRTALAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGSSHNKGQRTSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGDTELKEERLPGRKASCSAAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGSERQSLLPNGKENSSGTSRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGSGGGVQNGPPASPTLAHEAAPLPSGRPRPTTNLFTKLTSKLTRRVTDEPERIGGPEVTSCHLPWDKAETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
Protein: Regulator of RpoS (P0AEV1)
Organism: Escherichia coli (strain K12)
Function: Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation. In stationary phase, could also act as an anti-sigma factor and reduce the ability of RpoS to activate gene expression. Is also involved in the regulation of the mRNA polyadenylation pathway during stationary phase, probably by maintaining the association of PcnB with the degradosome.
Interaction partners:
- Anti-adapter protein IraD
- Anti-adapter protein IraP
- RNA polymerase sigma factor RpoS
- Anti-adapter protein IraM
- NTE family protein RssA
- NAD
- Fosmidomycin resistance protein
- ATP-dependent Clp protease ATP-binding subunit ClpX
- Aerobic respiration control sensor protein ArcB
- Stringent starvation protein B
Sequence:
MTQPLVGKQILIVEDEQVFRSLLDSWFSSLGATTVLAADGVDALELLGGFTPDLMICDIAMPRMNGLKLLEHIRNRGDQTPVLVISATENMADIAKALRLGVEDVLLKPVKDLNRLREMVFACLYPSMFNSRVEEEERLFRDWDAMVDNPAAAAKLLQELQPPVQQVISHCRVNYRQLVAADKPGLVLDIAALSENDLAFYCLDVTRAGHNGVLAALLLRALFNGLLQEQLAHQNQRLPELGALLKQVNHLLRQANLPGQFPLLVGYYHRELKNLILVSAGLNATLNTGEHQVQISNGVPLGTLGNAYLNQLSQRCDAWQCQIWGTGGRLRLMLSAE
Protein: Chitin deacetylase 3 (EC 3.5.1.41) (P82476)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Function: Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitosan is required to anchor melanin to the cell wall, for maintenance of cell wall integrity, and for proper cytokinesis. Chitosan offers an advantage during infection as it is less readily detected than chitin by host immunosurveillance mechanisms.
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.
Interaction partners:
Sequence:
MYGHLSLSALSLFAVVAAAPFRESWLQPRDSPVSQLFRRTAPDPNSNDYMSYYPGPGSTPNVSTIPQAWLDKLATVNLPNVPVATPDGGRPTYPNNEDDGDSTICSFTDQCRVEDDLYSPPGEKIWALSFDDGPTDVSPALYDYLAQNNISSSATHFMIGGNVITSPQSVLVAVKAGGHLAVHTWSHPYMTTLTNEQVVGELGWTMQALSDLNGGRIPMYWRPPYGDVDNRVRAIAKEVFGLVTVLWDSDTNDWAITDEPGQYSVASVEAYFDTLVTGNRTQGLLLLEHELDNNTVEVFETEYPKAVGNGWTVKNVADAFNMEWYLNSGKGNNDVVTTMSVAGTLTTATPTNTSTYVASSTAASSASVTDSAGVSIASAASSEASSSWAIANRPSHFVIAIACGLALAAIMV
Protein: Rhodopsin (P51489)
Organism: Rattus norvegicus (Rat)
Function: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P02699}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P02699}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P02699}. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia. {ECO:0000250|UniProtKB:P08100}.
Interaction partners:
- G protein subunit alpha transducin 1
- Rhodopsin kinase GRK1
- S-arrestin
- G protein subunit alpha transducin 2
- Guanine nucleotide-binding protein G
- Recoverin
- Guanine nucleotide-binding protein subunit gamma
- Arrestin-C
- G protein-coupled receptor kinase 4
- Guanine nucleotide-binding protein subunit beta-4
Sequence:
MNGTEGPNFYVPFSNITGVVRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWLPYASVAMYIFTHQGSNFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSLCCGKNPLGDDEASATASKTETSQVAPA
Protein: SWI/SNF complex subunit SMARCC2 (SWI3-like protein) (G5EF87)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKKGASKRRRDDDDGDVSMTGDDDDSRSGAAVKVEVPKGKEKDAEFSAPKGQKLTDLDEEGVQSTKEAPQLAEGNVIEQTHYIVVPSYAGWFDYNAIHQIEKRAMPEFFNGKNKSKTPDVYVAYRNFMVDTYRLNPFEYVSATACRRNLAGDVCSIVRLHSFLEQWGLLNYQVDSDARPAPVAPPPTSHFMVLADTPTGIQPMNPPGKESAGASGEPPKEEIKTEIESISTPGLKIDQYQKQAIAMRTKGAPPGRDWTEQETCLLLEALEMFKDDWNKVCDHVGTRTQHECVLKFLQLPIQDPYLTENLSSDKAEAAPGGAAKEVLGPLAFQPVPFSQSGNPVMSTVAFLASVVDPQVAAAATKAAMEEFGKLKEEIPPLVAEAHEKNVAAMAEKTGQVDGAVGLTKSGLKPAEEAAGDSDEKMDTNTNDDVPSTTEAKSAIDKGVQAAAASCLAAAAVKAKHLAQIEERRIKSLVAQLVETQMKKLEMKLRHFDELEQIMDKERESLEYQRHQLILERQAFHMDQLKYLENRAKHEAHSRMTSSGALPAGLPPGFEVTGPPQPTPQVQISAQEAAIPEKMDTSEAATAARPPSTPQAPQAPPVQAAPAPVQAPQAPQAPPQAYQGYGGPGGPPQQAYRYPPQQGQQYSPYPPPQQQQQHQAQQAQSQAHYGPPGGGQGPPPPPQGQQYYGGPPPPGQPYGPPGGYPPQQQRPPYQAQPYPGPPPPQQQRGYGYPPPPQPGHPYQQPYGQMPPPPHGQYQPQQQQGGPMGPPGGHHEGGDGGDSQQKQE
Protein: Pleckstrin homology domain-containing family G member 5 isoform X2 (Pleckstrin homology domain-containing, family G (with RhoGef domain) member 5b) (A0A0G2L933)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MVPNKWIMHPALHKSPPRSWLGIRLRLHEKSSQDEECVLCQHPDCPKRRHASKVCHHPDCQELNGKSPLHLCESCDSRCHLDESDSMHFDRHPRFDVQPQGSILARNVSTRSCPPRTSPPSDLEEDEEASTERGERKAGGLKLKAREGNKPRRHHTDNPRRECFSLKFDLNIDIDTEIVPAVKKKTLREVLGPIFERKGIELFRVDLFLDQSNTPLSLDFEAFRFGGRYLKVKARPGDELKVEQSVKDLRSLSLPNIKPSVGGSVYILTPATDKPEHSSLPRRDSVDILGQARRTKDMKQFLGDASIPSMDTLALLGGSLPTAAPGGSLTAGPNNCKNRPPNRFSIFFGAGAEKEVDRVQLLNTKLQAYSQFGLPKLPPQLAFHQDSWEEEEEEPNLTLEDSWRTLLDDPESLSRRQFQQQEAIWELIQTEATYIKKLRVITDLFLCGLLNLQDNSLLGEVEPTRLFSNIQDIVRLHCTLWVQVMFPALEKARGSRSLIEPTDLQEGFSTFASRFQPYIRYCMEEESCMEYMRSLLRDNELFKIYITWAETNKQCNRLKLADMLVKPHQRLTKYPLLLKTILKKTEDQASRDALNNMVACVEGFINGVDSQMRQRQEQQKLAATSARVESYEAVEGASEEVEKALKEFSRIDLTAPMIGTSPEETRQLHLEGALRMKEGKDSRMDAYCFLFTDLLLITKPVKRLEKVKVVRQPLLLHNVVCRELKDPGSFVLIYLNEFKSAVAAYTFQANSAAQGKSWTDAICNVQNQLQRLRSEEARRQKACLKKRLLDNQEDEDSCNSTNSSPHLRHKDQSNSQSDGSTETLSVMDMDESGLSLDPSVLHSDLGGHSDPDSAILQQNPELEPHLNSQDASDLDPQYRSMSMDSAYGTLSPESMLETQNPAAPVQEEEKEEEDKESTETTGDEEGDDEEDKISVGSQNSITLSFNKLRRQAPVQRRLPFLERLVGKSRSEDNLLSTVHQDIPKKKIKSRHTWEQRVKHTEPALSRSLTELKAAESDESLPTEESHRLTCSLPSAVLMDTLKRAKMARETGTGQIPNSSASDGELSPPAGVEGTGNRRQKTQQHKKLTLAQLYKIRTTLVLNSTLTASEV
Protein: NuA3 HAT complex component NTO1 (Q12311)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Chromatin modification-related protein EAF6
- Protein YNG1
- Histone acetyltransferase SAS3
- Transcription initiation factor TFIID subunit 14
- NuA3 HAT complex component PDP3
- Histone H3
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- Histone acetyltransferase ESA1
- Histone acetyltransferase SAS2
- Chromatin modification-related protein YNG2
Sequence:
MNRGSLDDGPKLREEKHFQDFYPDLNADTLLPFIVPLVETKDNSTDTDSDDISNRNNREIGSVKSVQTKELIFKGRVTTEPLVLKKNEVEFQKCKITTNELKGKKNPYCVRFNESFISRYYHINKVRNRKSYKQQQKEFDGVEAPYFTKFSSKEAPNITISTSTKSAIQKFASISPNLVNFKPQYDMDEQDELYLHYLNKRYFKDQMSHEIFEILMTTLETEWFHIEKHIPSTNSLIARHNILRDCKNYELYGSDDGTGLSMDQACAVCLGTDSDNLNTIVFCDGCDIAVHQECYGIIFIPEGKWLCRRCMISKNNFATCLMCPSHTGAFKQTDTGSWVHNICALWLPELYFSNLHYMEPIEGVQNVSVSRWKLNCYICKKKMGACIQCFQRNCFTAYHVTCARRAGLYMSKGKCTIQELASNQFSQKYSVESFCHKHAPRGWQTSIEGINKARKYFSLLSTLQTETPQHNEANDRTNSKFNKTIWKTPNQTPVAPHVFAEILQKVVDFFGLANPPAGAFDICKYWSMKRELTGGTPLTACFENNSLGSLTEEQVQTRIDFANDQLEDLYRLKELTTLVKKRTQASNSLSRSRKKVFDIVKSPQKYLLKINVLDIFIKSEQFKALERLVTEPKLLVILEKCKHCDFDTVQIFKEEIMHFFEVLETLPGASRILQTVSSKAKEQVTNLIGLIEHVDIKKLLSRDFIINDDKIEERPWSGPVIMEEEGLSDAEELSAGEHRMLKLILNSG
Protein: Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog) (Q9JJC8)
Organism: Mus musculus (Mouse)
Function: Acts as a selective Mg(2+) transporter.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18667602}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:18667602}. Note=Recruited to the cell membrane in response to low extracellular magnesium.
Interaction partners:
- Gamma-tubulin complex component 5
- Cytoplasmic FMR1-interacting protein 1
Sequence:
MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATFVVIVALIFIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELLAGKPVLQHPLAWILLFSLVVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVSFRKDEKAMNGNLSSMYEVLNNNEDDLPCGIEHTGENISRRNGNLPSF
Protein: Histone-binding protein MSI1 (CAF-1 p48 homolog) (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Protein MULTICOPY SUPPRESSOR OF IRA 1) (AtMSI1) (Protein medicis) (WD-40 repeat-containing protein MSI1) (O22467)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair, and the fertilization independent seed (FIS) complex, a polycomb group protein complex which is required to maintain the transcriptionally repressive state of homeotic genes throughout development. Required for several aspects of plant development including normal leaf expansion, correct development of flowers, normal endosperm development, repression of parthenogenetic seed development and repression of floral homeotic genes in leaf tissue. Also required for the recruitment of chromosomal DNA into heterochromatic chromocenters. Also involved in regulation of imprinted genes. Acts together with RBR1 to repress the expression of MET1 during female gametogenesis. This in turn activates expression of the imprinted genes FIS2 and FWA.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Histone-lysine N-methyltransferase CLF
- Chromatin assembly factor 1 subunit FAS2
- Polycomb group protein VERNALIZATION 2
- Chromatin assembly factor 1 subunit FAS1
- Histone-lysine N-methyltransferase MEDEA
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
- Histone-lysine N-methyltransferase EZA1
- Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM
- Retinoblastoma-related protein 1
- Polycomb group protein EMBRYONIC FLOWER 2
Sequence:
MGKDEEEMRGEIEERLINEEYKIWKKNTPFLYDLVITHALEWPSLTVEWLPDREEPSGKDYSVQKMILGTHTSESEPNYLMLAQVQLPLDDTESEARQYDDDRSEFGGFGCATGKVQIIQQINHDGEVNRARYMPQNPFIIATKTVNAEVYVFDYSKHPSKPPLDGACNPDLKLRGHSSEGYGLSWSKFKQGHLLSGSDDAQICLWDINATPKNKSLDAQQIFKAHEGVVEDVAWHLRHEYLFGSVGDDQYLLIWDLRSPSASKPVQSVVAHSMEVNCLAFNPFNEWVVATGSTDKTVKLFDLRKLSTALHTFDSHKEEVFQVGWNPKNETILASCCLGRRLMVWDLSRIDEEQTVEDAEDGPPELLFIHGGHTSKISDFSWNPCEDWVISSVAEDNILQIWQMAENIYHDEDDAPGEEPSKAS
Protein: E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) (Q6ZQF7)
Organism: Mus musculus (Mouse)
Function: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (By similarity). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A. Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis.
Interaction partners:
- Histone acetyltransferase KAT7
- Inhibitor of growth protein 4
- Chromatin modification-related protein MEAF6
- Inhibitor of growth protein 5
- Protein Jade-3
Sequence:
MEEKRRKYSISSDNSDTTDGHVTSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRLLPPLKGPPTQMSPDSPTLGEGAHPDWPGGSRYDLDEIDAYWLELLNSELKEMEKPELDELTLERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCITAFHVTCAFDRGLEMRTILADNDEVKFKSLCQEHSDGGPRSEPTSEPVEPSQAVEDLEKVTLRKQRLQQLEENFYELVEPAEVAERLDLAEALVDFIYQYWKLKRRANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHTICKLQEQIFHLQMKLIEQDLCREPSGRRSKGKKNDSKRKGREGPKGSSPEKKEKVKAGPESVLGQLGLSTSFPIDGTFFNSWLAQSVQITAEDMAMSEWSLNSGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPSPLQDGPSARTTPDKQPKKAWAQDGKGTQGPPMRKPPRRTSSHLPSSPAAGDCPVPATLESPPPLASEILDKTAPMASDLNVQVPGPTVSPKPLGRLRPPREMKVSRKSPGARSDAGTGLPSAVAERPKVSLHFDTEADGYFSDEEMSDSEVEAEDSGVQRASREAGAEEVVRMGVLAS