wanglab/gogpt-training-data huggingface dataset:
Protein: FERM domain-containing protein (Q95XN3)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MGVLSLTVSSAEKGIKKTMQFEPSTLIYDAAKLIREKFAMHDVNANEYGIFRLDENPSKSLWMDNGRTFEHYLVRNKDEIEYKRKIRLLKVRMLDGAVKTISVDESQPVSQLMMTVCNKIGISNYEEYSLVRDDILMQNGGGGGGGGGQNGGSTWNLKEKESRSKSSDRGGGGIYGTMRKKNEQKLEELRKKLHTDEELPWLDHTKTLREQGITEEETLILRRKYFFSDSNVDSRDPVQLNLLYVQCRDGILRGLHPVEKETAFQLAALQSHIQYGDFPYDKPKFHLDGRDVLPKEYAKNKENEKKVVAMYKELSGTSELDAKSKYVHLCRGLKTYGVTFFVVKEKLPGKNKLVPRLLGVNKESVMRVDENSKQILKEWPLEQVRRWVPSAKCFSLDFGDYQDGYYSVQTTDGEKIAQLIQGYVDIILKKKRTQDHQGIEGDEGSTMLEDMVAPAKATLVAHGQIGSGQHATDGLVAVRGVLRTPQGGQGYGINGAQYGAVSGEITSQELARAQRLRYQDMYQHPQRALIGTIEATIRAVEDAEIELEAEPQIDIPRFNDDYSQNRWMEEQQAVNKENVNERLAAMGAATAQVVQWTAVEEYDDRVGTAIATIGSNLPDVSRNVRDLGAFMEHRERGDLLDATKKLCGAFGKFLNTVNPETEARRNEVFRTAGHVGETSQHLINVMEAPNEGQQKFDERLVQSAKNVATSTAQLVLCAKTISAECDEPQVQERVIQSATKCAFATSQLVACARVVAPTIDNNACQQQLSTAATEVTQSVNNLLHDAEHAVYQQSSLTDIHEAARQVTSALDSLLEHAKCSPKTQTTRREEEEMYNEVLRRTNRMVVHQGPSEDLTREARKVVRHSQLLTEQFQHEAHQRPEHRERLLDAAAKVAHATSEMILATEQAESQPRQVETEYALRTAAERLGQVTNETTQEQQEQHIMQRLEQAAKQTAYDATQTISAANSAKKKQQEHKRTETTEQLLVDDSHTILRIR
Protein: DNA replication complex GINS protein PSF3 (A0A0S2Z5P2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367161}.
Interaction partners:
Sequence:
MSEAYFRVESGALGPEENFLSLDDILMSHEKLPVRTETAMPRLGAFFLERSAGAETDNAVPQGFALLPRLECSGVIWLTAALTSQAPEILPPQPPMWLVLQGSKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADPNVVDLHKMGPHFYGFGSQLLHFDSPENADISQSLLQTFIGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQTGQKGLNDFQCWEKGQASQITASNLVQNYKKRKFTDMED
Protein: Glutamate receptor 3.7 (Ionotropic glutamate receptor GLR5) (Ligand-gated ion channel 3.7) (Q9SDQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glutamate-gated receptor that probably acts as non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized membrane protein At3g27390
- Putative cyclic nucleotide-gated ion channel 7
- non-specific serine/threonine protein kinase
- DEAD-box ATP-dependent RNA helicase 36
- Protein DEHYDRATION-INDUCED 19 homolog 2
- F-box protein SKIP5
- Calcium-dependent protein kinase 16
- Probable cyclic nucleotide-gated ion channel 3
- Cyclic nucleotide-gated ion channel 18
- Calcium-dependent protein kinase 19
Sequence:
MGLGIDPSVAITALIVVILVVPMDCQRPQLVNIGAVFAFDSVIGRAAKVALEAAVSDVNNDKSFLKETELRLLMEDSACNVFRGSFGAFELLEKEVVAMIGPISSSVAHTISDIAKGLHFPLVSFAATDPTLSALQFPFFLRTTPNDAHQMSALVDLINFYGWKEVISVYSDDELGRNGVSALDDELYKKRSRISYKVPLSVHSDEKFLTNALNKSKSIGPRVYILHFGPDPLLRIFDIAQKLQMMTHEYVWLATDWLSVTLDSLSDKGTLKRLEGVVGLRQHIPESVKMEHFTHKLQSNRSMNAYALHAYDTVWMIAHGIEELLNEGINITFSYSEKLLHARGTKLHLEKIKFFNSGELLLEKLLKVNFTGIAGQVQFGSGRNVIGCDYEIINVNKTDVHTVGFWSKNGGFSVVAPKTRHSQKKTSFVSDEKLGDITWPGGGREKPRGWVIADSADPLKIVVPRRVSFVEFVTEEKNSSHRIQGFCIDVFIEALKFVPYSVPYIFEPFGNGHSSPNYNHLIQMVTDGVYDAAVGDIAIVPSRSKLVDFSQPYASTGLVVVIPANDDNATWIFLRPFTSRLWCVVLVSFLVIAVVIWILEHRINEDFRGPPRRQLSTMLLFSFSTLFKRNQEDTISNLARLVMIVWLFLLMVLTASYTANLTSILTVQQLPSAITGIDSLRASEVPIGYQAGTFTLEYLTYSLGMARSRLVPLDSTEEYEKALKLGPTNWGGVAAIVDELPYIELFLAERTGFKIVGEPFMHRGWGFAFKRDSPLAIDMSTAILKLSETRKLQEIRKKWLCKTNCAGKSNWNPEPNQLHLKSFKGLYLVCIAITVSAFLVFVLRMIRQFVRYRRMERTSSMPRASWSASPTLRLRELVFDFVEFVDEKEEAIKRMFRRSDDSNNNPSHVGEVQADTEVPRN
Protein: Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) (Q14699)
Organism: Homo sapiens (Human)
Function: Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling. May play a pivotal role in the formation and/or maintenance of lipid rafts.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}; Lipid-anchor {ECO:0000269|PubMed:12805216}. Cytoplasm {ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. Membrane raft {ECO:0000269|PubMed:12805216}. Endosome {ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. Early endosome {ECO:0000269|PubMed:21266579}. Note=Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3 (PubMed:21266579). Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195). {ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.
Interaction partners:
Sequence:
MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNEGYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVGVIPQYHSSVNSAGSSAPVSTANSTEDARDAKNARGDHASLENEKPGTGDVCSAPAGRNQSPEPSSGPRGEVPLAKQPSSPSGEGDGGELSPQGVSKTLDGPESNPLEVHEEPLSGKMEIFTLFNKPKSHQKCRQYYPVTIPLHVSKNGQTVSGLDANWLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLTDGVFIFEAVSTEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVVKTTSEGSVSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKSKGKLSARDKQQAEENEKNLEDQSSKAGDMGNCVSGQQQEGGVSEEMKGPVQEDKGEQLSPGGLLCGVGVEGEAVQNGPASHSRALVGICTGHSNPGEDARDGDAEEVRELGTVEEN
Protein: Hermansky-Pudlak syndrome 4, isoform A (A1ZAX8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH27401p
- Uncharacterized protein, isoform A
- BLOC-2 complex member HPS5 homolog
- Dysbindin protein homolog
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Vacuolar fusion protein CCZ1 homolog
- Rab32, isoform B
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- Biogenesis of lysosome-related organelles complex 1 subunit 2
Sequence:
MFRDWRKTKHKRWQKVQQKQQTSILTERETMIVFVYDTECLTDEADDPISAVLYFHPSWVSDSQKVALCGQLMGTSYFLKDCFFNPRILALQNGKFVLKEFGRFILAIGTDRNIGDQLLEHRADLLSSLLKFFHRDVQTLYAQYAAPPALNRRNLSEKLYHIFETYLPMLQRNGNTFQNVPRLRMPKTASHIFLEAIQTLQSCQQTKGILGGAILYHNKVVASQLSDMVTKHLVLTDPLHIRTAAEQVTNHPEFHIPNGVQMLVVYLEHMQYRQLAGEAQRAQNLQMNTAQLTQNGMPFQYAKRKIKRDKSLIFTHIPEEEHAPEQQGAVEQLPPARPKSMRPTHLPLRIKSMQSKELPESGIASINFDETDSYPQFIGRTSVCNTPMTENKVLPVANVMSICANPEDEGKEEDIHNSNGKTHSRRNSLKVDVEKFFQNFISNPNKQLTRRKSSADLQDALRAISKKLNNFTHGLKTDVNRNGSGNGDVSSDSPDFIEDDDKITSRTISDPTYPVFNTNGQQISRSLFQQFLDQYRKLWGVASEQAHEDAELAALVAEFQEFNAEIQKLDEHMRQQAAEASSADRNLNVSAAKTPLDKRSMTLPLKSAGESTFGERASGRSGAGGVPLTPLMAKLSVLALSETTPIEIQTPLTTSKVFPRRSSLKCEDAVDALAALTTAPAQPPGPIQPDGLQRTELYICGQQNMTLLLLMEEGTCQQQQVVQKMFDICVAKFPHMESQLNQTLNVNVEGDNRDGSNYSFMCVDSKWDVLQRNGPWNPLELNILESMHSIHSSGHHLTDLILRSNDSVYYGHKNGRTEFFYKEPTHQINGIPPPSDPIGNIQSRAKSRLERDHSYMLF
Protein: Uncharacterized protein (Q38D45)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIPAAMLVANVFLLAACLDSVAAVLLPFPPSFYVTTGTTIPFISSPPVAQSGNIYASNESKRLRVDNFFMGFQYSFVADGKLGRGFVFESIEPITTTTASGNNNNNNNNNNNNNNSSEKKSGRGGEERISCRSFALNRGLTGFGVPDEFVRHAESSLVRGVKVWRYTGYSRSGVGPLQEVDYFIRNGTFHAVPWRVQIRRRQTALKELTGSPMTLPNWRYFGGLFFDEVAVPEGPYEDKLERLMQDTTVTLDFYNFVPAEPHPSVFSVPDNCKEVSARFTGNDVDISLAQRFLVDLSLYTPVGREMLREELNSA
Protein: MKIAA0198 protein (Q6ZQG6)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
ITWPFAISLAMTTFFTSVPPWIQDAKQEEEVGWKLVPRPRGREAESQVKCQCEISGTPFSNGEKLRPHSLPHPEQRPYSCPQLHCGKAFASKYKLYRHMATHSAQKPHQCMYCDKMFHRKDHLRNHLQTHDPNKEALHCSECGKNYNTKLGYRRHLAMHAASSGDLSCKVCLQTFESTQALLEHLKAHSRRVAGGAKEKKHPCDHCDRRFYTRKDVRRHLVVHTGRKDFLCQYCAQRFGRKDHLTRHVKKSHSQELLKIKTEPVDMLGLLSCSSTVSVKEELSPVLCMASRDVMGAKAFPGMLPMGMYGAHIPTMPSAGMPHSLVHNTLPMGMSYPLESSPISSSAQLPPKYQLGSTSYLPDKLPKVEVDSFLAELPGSLSLSSAEPQPASPQPAAAAALLDEALLAKSPANLSEALCAANVDFSHLLGFLPLNLPPCNPPGATGGLVMGYSQAEAQPLLTTLQAQPQDSAGAGGPLNFGPLHSLPPVFTSGLSTTTLPRFHQAFQ
Protein: Protein CYTOKININ-RESPONSIVE GATA TRANSCRIPTION FACTOR 1 (OsCGA1) (Q6YW48)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters (By similarity). Influences the expression of nuclear encoded chloroplast-targeted genes. Regulates chloroplast development and promotes chlorophyll accumulation. Modulates plant architecture (e.g. height, length and width of leaf blades, and flowering tillers production) and represses tillering, probably by modulating number of cells. Promotes senescence. Involved in grain filling, panicle development and starch production.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SZI6, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
Sequence:
MSTIYMSQLPATLPLMEGDQDQGLYPAFHRAKDPPILFPFMIDSAVEHQGQIYGDQGLRRQQVLGESNQQFNDHMMMGGSDVFLTPSPFRPTIQSIGSDMIQRSSYDPYDIESNNKQHANGSTSKWMSTPPMKMRIIRKGAATDPEGGAVRKPRRRAQAHQDESQQQLQQALGVVRVCSDCNTTKTPLWRSGPCGPKSLCNACGIRQRKARRAMAAAANGGAAVAPAKSVAAAPVNNKPAAKKEKRAADVDRSLPFKKRCKMVDHVAAAVAATKPTAAGEVVAAAPKDQDHVIVVGGENAAATSMPAQNPISKAAATAAAAAASPAFFHGLPRDEITDAAMLLMTLSCGLVHS
Protein: Karyopherin beta (Q8I3M5)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nucleoporin NUP221, putative
- Histone H4
- GTP-binding nuclear protein
- Transportin
- Importin subunit alpha
- Importin-7, putative
- Importin subunit beta, putative
- Sentrin-specific protease 1
- RNA and export factor binding protein, putative
- Histone H3
Sequence:
MDKIVEVIEGLSSSESHIRNECENTLNYYKKNDLNNTVLSILKLLKTHKDSQVRLQCAILIRNIFRVYIKSTHVDVEEKEKNENSIGNAEEENYWVLLPDNLKNIVKSELISNIGTETDKMVRSNICNNIIDLSSKLLLHNQWPELLSVTFEFCNSNNVDVLISGYKILGGILSCIPDELDGKQEIISSICMKGLNSSNVQVRGECINLISCIVEDNSSSLVKSVHGCIPLILQSLSLMAKNSSSDIAVLEECEKVLQSIGKMIDYNAKFFTKHITSLCDILFSICMKDENELNYDFDNSLKSLSIEALVTIPERRPKMALSVPHFVDKIIHLSMLFMLDINNDCFNEWMNSIKEGKDDSQELYDIGEESLDRVGKAFSELEEAEFIHILFNKVSEFLMKNTWEHKYVGIMAIAQTIEYLPEDEIEEQLEHVIKMLLQILVDQDVRVRYAACQAIGQISLDHQPYVQKEFFSEILSALINTMNDVHLRVQSHATAAFVNYAEELDKMALLPYADIIIDILLQKLNSSNYLLVREQAVTAIAVIAGVIEEDFLKYYSTVVPMMKDIIQKAVSEEERTCRGKAIECISIIGLSVGKDIFIEDAKECMNALLQISSTKMDPDDTVKEYIQEAIGRICRALGNDFYPYLSSIVPTILSVLSVLPKPLTDDEEDLTITMVSNGQYVGLKTSLLEDQEKALDLLIIIIEVLKENYKDYIQATATAVLPMLNYELSDEIKQKALTAVSELIESARILSEKTDNDKSMLLAILTAAAEKVLKSLLETKLDDNYEYILDVMIIESHGLYMCLQKAGSNVLPENTLKLFFNQIFALLQYSTDRRVVYNQKKNNDDVDEDELLIIDREEELEQNYRTNLLDILGVLIKYHPTQFLNTCCELCIGFINNYMNSPNSEDVALALYVCDDLLEFLQEKSVNLWDFFMNPLLLNINHADDKVKQAACYGVIQATKIEAFGKYANIAVEYLLKLVHESTSNKKPKEYISAIDNAIAALGDVVLMHTSKFNNAEDLIKVWLNHLPIKEDDAEGRRVHKNLIDLVSQNHPLLFGKDNSNTAKIIEIFLTIYETDFSDTDCNKKISTLINSLDKSYLNNLASSTLSHKQAKKLNNILNPNRK
Protein: MKIAA0327 protein (Q5DTQ9)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
TMAASKNQHRHGRLVLLCTLMGTLCKISVGQIRYSVPEETDKGTVVGNISKDLGLEPRELAERGVRIVSRGRSQLFSLNPRGGSLVTAGRIDREELCAQSTPCLVNINILVEEKGKLFGVEIEITDINDNNPKFHVGDLEVKINEIAAPGARYPLPEAVDPDVGINSLQSYQLSPNRHFSLHLQTGDDGTINPELVLERTLDREEEPTHHLVLTASDGGEPRRSSTALIQITVLDTNDNAPVFDQPVYRVKVLENVAPGTLLLTVRASDPDEGVNGKVTYKFRKINEKQSLLFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDVGALLGRSKVIIMVEDVNDNRPEVTITSLFNPVLENSLPGTVIAFLNVHDQDSGKNGQVVCYTHDNLPFKLEKSIDNYYRLVTWKYLDREKVSTYNITVIASDLGAPPLSTETYIALTVADTNDNPPRFSHTSYTAYLPENNLRGASIFSLTAHDPDSQENAQVTYSVSEDTIQGVPLSSYISINSDTGILYALQSFDFEKIQDLQLLVIATDSGSPPLSSNVSLSLFVLDQNDNAPEILYPSFPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQNLVMAVQDHGQPPLSATVTLTVAVANSIPEVLADLSSIMTPEVPEDSDLTLHLVVAVAVVSCVFLVFVIVLLALRLQRWQKSRQLQGSRSGLAPAPPSHFVGIDGVQAFLQTYSHEVSLTSGSQTSHIIFPQPNYADMLINQESCEKNDSLLTSIDFHENKDEDACAPQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Protein: 40-kDa huntingtin-associated protein (HAP40) (CpG island protein) (Factor VIII intron 22 protein) (P23610)
Organism: Homo sapiens (Human)
Function: RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16476778}. Nucleus {ECO:0000269|PubMed:16476778}. Early endosome {ECO:0000269|PubMed:16476778}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q00558}. Note=Diffuse presence in the cytoplasm and accumulation in the nucleus (PubMed:16476778). In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (By similarity). Colocalized with HTT in endosomes (PubMed:16476778). In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (By similarity). {ECO:0000250|UniProtKB:Q00558, ECO:0000269|PubMed:16476778}.
Interaction partners:
- Huntingtin
- Ras-related protein Rab-5A
Sequence:
MAAAAAGLGGGGAGPGPEAGDFLARYRLVSNKLKKRFLRKPNVAEAGEQFGQLGRELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEAARLFLRQERDARQRLVCPAAYGEPLQAAASALGAAVRLHLELGQPAAAAALCLELAAALRDLGQPAAAAGHFQRAAQLQLPQLPLAALQALGEAASCQLLARDYTGALAVFTRMQRLAREHGSHPVQSLPPPPPPAPQPGPGATPALPAALLPPNSGSAAPSPAALGAFSDVLVRCEVSRVLLLLLLQPPPAKLLPEHAQTLEKYSWEAFDSHGQESSGQLPEELFLLLQSLVMATHEKDTEAIKSLQVEMWPLLTAEQNHLLHLVLQETISPSGQGV
Protein: Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase Acsl3) (EC 6.2.1.15) (Brain acyl-CoA synthetase II) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) (Q63151)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity.
Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Interaction partners:
- Fatty acid synthase
- Carnitine O-palmitoyltransferase 1, liver isoform
- Lipoprotein lipase
- Lysosomal thioesterase PPT2
- Palmitoyl-protein thioesterase 1
- Palmitoyl thioesterase CPT1C
- Long-chain-fatty-acid--CoA ligase 1
- Beta-alanine-activating enzyme
- Carnitine O-palmitoyltransferase 1, muscle isoform
- Peroxisomal acyl-coenzyme A oxidase 1
Sequence:
MNNHVSSTPSTMKLKQTIHPILLYFIHFIISLYTILTYIPFYFLCESKQEKPNHIKAKPVSSKPDSAYRSVNSMDGLASVLYPGCDTLDKVFMYAKNKFKDKRLLGTREILNEEDEIQPNGKVFKKVILGHYNWLSYEDVFIRALDFGNGLQMLGQKPKANIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHGLNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGVIVHTMAAVQALGVKADVDKKAHSKPLPSDIAVIMYTSGSTGIPKGVMISHSNIIASITGMARRIPRLGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSVLKPTLMAAVPEIMDRIYKNVMNKVNEMSAFQRNLFILAYNYKMEQISKGCSTPLCDRFVFRNVRRLLGGNIRVLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESTGAGTITEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQNVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFDPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLIDNICAYANSYHSYVIGFVVPNQKELTELARTKGFNGTWEELCNSSEMENEVLKVLSEAAISASLEKFEIPLKIRLSPDPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
Protein: Protocadherin 9 (B2RY69)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDEDAGENKAVTLSILNDNENFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDIDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKALHTLVLVFLYVNDTAGNTSYIYDLIRRTMETPLDRNIGDSGQPYQNEDYLTIMIAIVAGAMVVIVVIFVTVLVRCRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAELEEQGIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSYSKNDNIPVTHQKCPGSTSFHIRENEESHSESQRRVTFHLPDGSQESYSDSGLGDHEPVGSGTLISHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSDNCWMPPGLGPYQHPKSPLSTFAPQKEWIKKDKLVNGHTLTRAWKEDTNRNQFNDRKQYGSNEGHFNNGGHMADIPLANLKSYKQAGGTIESPKEHQL
Protein: ADAM metallopeptidase with thrombospondin type 1 motif, 13 (D4A0T9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- von Willebrand factor
- Coagulation factor VIII
Sequence:
MSQLCLWLPCQPFLAASIRGILTGAIFILGCWGLSDFQKSFLQDLEPKDLSSSFSRHTAPLTGHPSSHLQRLRQRRTSEDILHLELLVAVGPDVYQAHQEDTERYVLTNLNIGSELLRNPSLGAQLQVHLVKLIILSDSENTPNITTNITSSLMSVCEWSQTINPHDDRDPSHADLIIYITRFDLELPDGNQQVRGVTQQGGACSPSWSCLITEDTGFDLGVTIAHEIGHSFGLDHDGAPGSGSTCEARGHVMASDGAVPAGGALEWSTCSQRQLQHLLSTGQMHCLWDPPGLQSGLTWHQLVAQPGLFYSADDQCRVAFGAGAVACTFSREGLDVCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKARCRSLAELAPVAVVHGHWSSWGPHSPCSRSCGGGVITRRRWCNNPRPAFGGRACVGEDLQAKMCNTQACEKTQLEFMSEQCAQTDRHPLQLSQGSASFYHWDAAVQYSQGDTLCRHMCWAVGESFIVSRGDSFLDGTRCVPNGPREDGTVSLCLLGSCRTFGCDGKMDSQQVWDACQVCGGDNSTCTSQNGSFTAGRAREYVTFLIVTPNMTSAHVINHRPLFTHLAVRIQDHYIVSGKSSMSPNVTYPSLLEDYRVEYRVTLTEDQLPRLEEIHIRGPVRDDIEIQVYRRYGGEYGGLTHPDITFTYFQRKQQAAWVWAAKRGPCSVSCGAGLRWVTYSCQDQAQNKWVRNAQCQGSPQPPAWQEPCVSAPCPPHWVADDFGPCSVSCGGGLRERSLRCVEAHNGFLKTLPPAPCRAVAQQPAGEVENCNSQPCPTGWEVSDPSPCVSSACEPGLESGSGTCVPRVGDSEKPAMAGPCRPDDMSPVPEPCVRTTCSPGSGPVDTMSLGEEASSPVGSGKPSSQAEHVWTPLVGLCSISCGKGLKELYFLCMDSVLKMPVQEELCGLASKPPSRWEVCRARPCPARWETRVLAPCPVTCGGGRVPLAIHCVQLDHGRPVSVPHSKCWPAPRPGSFEDCSPEPCPARWKVLPLGPCSASCGLGTATQMVACVQLDQGHDNEVDETFCKALVRPPASVPCLIADCAYRWHISTWTECSVSCGDGIQRRHGTCLGPQAQVPVPANFCQHLPKPVTVRGCWAGPCAGQKISSSLPHKEATLPSQTLAAVTAASLQWSQPQAQAHSLFPDSQSLGLQETLEEPGACGRQYLEPTGTIDMRGQGQLDCVVAIGRPLGEVVTLQILESSLKCRAGELLLLWGKFTWRKMCWKMSGRTFSTKANTVVVRQHRVLPGGGVLLLYRSQPAPGTFYKECDRQLFGPRGEITSPSLSPDGRKAGTCRVFVSVAPQARIAIRALASDMGTASEGTSANYVSIRDIHGLKTTTFWGQQVLYWESEGSEAELEFSHGFLEAHASFQGQYWTIPPRTPEQVNSVALS
Protein: UDP-glucuronosyltransferase 2B7 (UDPGT 2B7) (UGT2B7) (EC 2.4.1.17) (3,4-catechol estrogen-specific UDPGT) (UDP-glucuronosyltransferase 2B9) (UDPGT 2B9) (UDPGTh-2) (P16662)
Organism: Homo sapiens (Human)
Function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10702251}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 3A4)
- Cytochrome P450 2D6
- Cytochrome P450 3A5
- Cytochrome P450 2A6
- UDP-galactose translocator
- Cytochrome P450 2E1
- Cytochrome P450 1A1
- Sulfotransferase 1E1
- Beta-glucuronidase
- Cytochrome P450 1B1
Sequence:
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND
Protein: Probable trafficking protein particle complex subunit 13 homolog (Q95TN1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RE19263p
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 11
- Trafficking protein particle complex subunit 5
- FI18195p1
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit 10
- Trafficking protein particle complex subunit 6B
- Probable trafficking protein particle complex subunit 2
- Protein brunelleschi
Sequence:
MEMVEPDAHLVALKVMRLMRPTLVGLGPVVTCEPTDLVQRFSSSQESDGMSGACAETLAAGQVLLLPQSFGSIYLGETFASYICVHNTTPNPVECVTVKADLQSNTSRINLSMHENAKSPVVLPPGGTIDDVIRYEVKEIGTHILVCEVNYSTPAGYAQSLRKFFKFQVLKPLDVKTKFYNAEIDEIYLEAQIQNVTTSPFCLEKVELDGSEDYSVTPLNTLPNGESVFTVKHMLQPNNSCQFLYCIKPKGDIAKNVDTLRQFNNVGKLDIVWRSNLGEKGRLQTSQLQRLPFECKTLRLEVLDAKNTIKIGTIFTFNCRVTNTSEHPMKLNVRLAAKFSPDSQYTGCADFMLNLLQSGESAEFPLSVCPSKLGLVKITPLVLTNTLQNEQFTIENVVDVFVVNSDYDNDTTTHQNKLIRYESAASCLTQKQVQLQVV