wanglab/gogpt-training-data huggingface dataset:
Protein: TNF receptor associated factor 7 (A0A8I5ZSA7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGPAHTNSIAGRLPPLAPLPIRHGMRRTACPPSTLLAALTQPSLSAPCTPSPACPCAPRSRCLRRKRSRSLVLSWVSVPVNSPGRVNVQAAWEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNAKLTVVVNNIAVAEQIGELFIHCRHGCRAAGTGKPGVFEVDPRGCPFTIKLSARKDHESSCDYRPVRCPNNPSCPPLLKMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIKVNTIRAHDNPVCTLVSSHNMLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC
Protein: Peptidyl-prolyl cis-trans isomerase cyp6 (PPIase cyp6) (EC 5.2.1.8) (Rotamase cyp6) (Q9UUE4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16134115}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase 9
Sequence:
MSVLIETTVGDLVIDLFVKEAPKTCENFLKLCKLKYYNFCPFYNIQHNYTCQTGDPLGPTGDGGRCVWNVLNKGTRFFKAEFNPSLVHNKMGLVSMSTATISSRDDKLLVCGSQFIITLSDNLEGLDERYPIYGQVAEGFDTLLKINDAICDEEGQPYRDIRIKHTIILDDPFEDPPDLVEPLRSPSPTPEQLATVRIGENEQIESETSEDKLQREKEMEAEAEAVTLEMIGDLPFAHVAPPENVLFVCKLNPVTQDEDLELIFSRFGKIISCQVIRDKETGDSLQYAFIEFDNKESVEKAYFKMQNVLIDDSRIHVDFSQSVARYRQYYNSNRDRKRSSSRSDDREYHRRSDGRYDRSNYRDDYRHRRKERDHRDDQSSFRNERFSNYYGDDRSYHKRRNTGNKNCDDHLRDKSPERRYRYDRRYRDDRYR
Protein: Na(+)/H(+) exchange regulatory cofactor NHE-RF (G3GTH2)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Endomembrane system {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866}.
Interaction partners:
- Moesin
- Radixin
- Ezrin
- Sodium-dependent phosphate transport protein 2A
- Cystic fibrosis transmembrane conductance regulator
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Sodium-dependent phosphate transport protein 2C
- Protein kinase C beta type
- Protein kinase C alpha type
Sequence:
MSADAAAGEPLPRLCCLEKGPNGYGFHLHGEKGKVGQFIRLVEPGSPAEKSGLLAGDRLVEVNGENVEKETHQQVVSRIRGALNAVRLLVVDPETDEHLKKLGVPIREDLLRSQKSEQAEPPAAADAQATDQNEAEKSHLERRELRPRLCTMKKGPNGYGFNLHSDKSKPGQFIRAVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIKAGGDEAKLLVVDKETDEFFKKCKVIPSQEHLDGPLPEPFTNGEIQKESSREALVEAASESPRPALVRSASSDTSEELNSQDSPKRQESTEPSSTSSSSDPILDFNISLAVAKERAHQKRSSKRAPQMDWSKKNELFSNL
Protein: Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (A0A0C4DG89)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, Cajal body {ECO:0000256|ARBA:ARBA00004408}.
Interaction partners:
Sequence:
MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSYQPTNKGRYKVL
Protein: Nudix hydrolase 3 (AtNUDT3) (EC 3.6.1.-) (Q8L831)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Interaction partners:
- Small ribosomal subunit protein uS9x
- Large ribosomal subunit protein bL27c
- Nudix hydrolase 25
- 50S ribosomal protein L27
- Nudix hydrolase 11
- Nudix hydrolase 10
- Nudix hydrolase 4
- Jacalin-related lectin 36
- Nudix hydrolase 5
- Nudix hydrolase 9
Sequence:
MAEEHFDVLTKSGEKTGVSKPRGEVHRDGDYHRAVHVWIFVETTQQLLLQLRSDDKDSWPGQWDISSAGHISAGDTSLLSAQRELEEELGVKLPKDAFEKIFVFLQECVTNDGKFINNEFNDVYLVTILHPIPLEAFTLQKEEVSAVKYVPYEEYRNFLSKEDPAYVPYDVNGEYGKLFDIIRQRCQVNTEARSLSLQKQLQRYSPVTLEAKLTELSEADQKALGLIVKAAKIMDDIFYEQVWNSNPALRDWLKDHANASKLDKLKWDYFTINKSPWSSLDENEAFLSTADSAVKLLPGATKAIAGWKGLEYRAAFPVTKPPGANFYPPDMDKMEFTLWLNGLTEEQKHAATGFFSVIKRRSEANLDASDHLASSTKKLPDSNSDLYSIPYSEIYRPFLKKASEFLQKAGDLVSSPSLKKLLHSKAEAFLSNEYYESDIAWMDLDSKLDITIGPYETYEDEIFGYKATFETFIGIRDDKATADLKLFGDNLKLLEDNLPLESVYKSTDVSAAPIRVIQLIYNSGDVKGPQTVAYNLPNDEKIVKDRGTSMVMLKNVQEAKFEHILKPIAEITISKEQRGLVDFDSFFTHTICHECCHGIGPHTITLPGGQTSTVRKELQEVHSAMEEAKADIVGLWALKFLITKGLLSKSMVESMYVSFLAGCFRSIRFGLTEAHGKGQALQFNYLYEKGAFVFHEDSTFSVDFAKIEGAVESLSHEILTIQGKGDKNAATLLLNKYCTITGPLKTALENLERVKVPVDISPTFPLAEALMN
Protein: Thymidine kinase (EC 2.7.1.21) (F5HB62)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
Interaction partners:
Sequence:
MAEGGFGADSVGRGGEKASVTRGGRWDLGSSDDESSTSTTSTDMDDLPEERKPLTGKSVKTSYIYDVPTVPTSKPWHLMHDNSLYATPRFPPRPLIRHPSEKGSIFASRLSATDDDSGDYAPMDRFAFQSPRVCGRPPLPPPNHPPPATRPADASMGDVGWADLQGLKRTPKGFLKTSTKGGSLKARGRDVGDRLRDGGFAFSPRGVKSAIGQNIKSWLGIGESSATAVPVTTQLMVPVHLIRTPVTVDYRNVYLLYLEGVMGVGKSTLVNAVCGILPQERVTSFPEPMVYWTRAFTDCYKEISHLMKSGKAGDPLTSAKIYSCQNKFSLPFRTNATAILRMMQPWNVGGGSGRGTHWCVFDRHLLSPAVVFPLMHLKHGRLSFDHFFQLLSIFRATEGDVVAILTLSSAESLRRVRARGRKNDGTVEQNYIRELAWAYHAVYCSWIMLQYITVEQMVQLCVQTTNIPEICFRSVRLAHKEETLKNLHEQSMLPMITGVLDPVRHHPVVIELCFCFFTELRKLQFIVADADKFHDDVCGLWTEIYRQILSNPAIKPRAINWPALESQSKAVNHLEETCRV
Protein: Short-chain reductase protein NovJ (EC 1.1.1.-) (Novobiocin biosynthesis protein J) (Q9L9F8)
Organism: Streptomyces niveus (Streptomyces spheroides)
Function: Catalytic subunit of the NovJ(2)K(2) heterotetramer that catalyzes the NADPH-dependent reduction of the tyrosyl moiety of L-beta-OH-Tyr-S-NovH intermediate to yield the tethered beta-ketotyrosyl-S-NovH in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases.
Interaction partners:
Sequence:
MTSPADATTEVAVSQESVAMVTGAGRGIGAATAERLAAEGMAVIVVDRTEQDTRATVAAIRTAGGRARGIGCDVAVAQAVTAAVATAVEEFGRIDVLVNCAGINRDRLLLTMGDQEWDTVLDVNLGGTMRCSFAVGRHMRRQGHGRIINFSSVAARGNAGQTNYATAKGAIAGFTRTLAAELGPHGVTVNAIAPGFVATPMVDELAERLGGDRDSVMSEAAKSSAVGRIGTPEEIAATVVFVARPESGYLTGETVHVDGGRP
Protein: Large ribosomal subunit protein mL48 (39S ribosomal protein L48, mitochondrial) (L48mt) (MRP-L48) (Q96GC5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Interaction partners:
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein mL65
- Large ribosomal subunit protein mL51
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein mL39
- Large ribosomal subunit protein uL13m
- Mitochondrial ribosomal protein L40
- Large ribosomal subunit protein mL64
- Large ribosomal subunit protein mL50
Sequence:
MSGTLEKVLCLRNNTIFKQAFSLLRFRTSGEKPIYSVGGILLSISRPYKTKPTHGIGKYKHLIKAEEPKKKKGKVEVRAINLGTDYEYGVLNIHLTAYDMTLAESYAQYVHNLCNSLSIKVEESYAMPTKTIEVLQLQDQGSKMLLDSVLTTHERVVQISGLSATFAEIFLEIIQSSLPEGVRLSVKEHTEEDFKGRFKARPELEELLAKLK
Protein: Actin-related protein 2/3 complex subunit (Q7T372)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Arp2/3 complex 34 kDa subunit
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2-A
- Actin-related protein 3
Sequence:
MAYHSFLLEPISCHAWNKDRTQIALCPNNHEVHIYNKAGNNWNKIHVLKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGDAWKPTLVILRINRAARCVKWSPKENKFAVGSGSRLISVCYFEQDNDWWVCKHIKKPIRSTILCLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEEKPAPTAWGSKMPFGEVMFESTGTSGWVHGVCFSDSGNRVAWASHDSTVAVAEGGKTAVCTSLTSETLPLLCVTFITENSLVAAGHDCYPVLFVYDSNNAALSFGGKLDVPKQSAQKGMTARERFQNLDKKATTESKEAVLESLHKNSISQISLLDGGKAKCSKFCTTGMDGGMTIWDVKTLESAMKDLKIV
Protein: Protein FAM72A (Dpr4-related protein) (A1KXW8)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}.
Interaction partners:
- Zinc-regulated GTPase metalloprotein activator 1
Sequence:
MSTNNCTFKDRCVSILCCKFCKQVLSSRGMKAVLLADTDIDLYSTDIPPTNTVDFIGRCYFTGIHKCKLKDIACLKCGNIVGYHVIVPCSSCLLSCNNGHFWMFHSQAVYGINRLDSTGVNFLLWGNLPETEECTDEEMLEISAEEYIR
Protein: Carboxypeptidase A2 (EC 3.4.17.15) (P19222)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9UI42}.
Interaction partners:
- Carboxypeptidase A1
- Chymotrypsin like elastase 3B
- Mast cell carboxypeptidase A
- Chymotrypsin-C
- Chymotrypsin-like elastase family member 2A
- Latexin
- Chymotrypsinogen B
- Chymotrypsin-like elastase family member 1
Sequence:
MRLTLLLAALLGYIYCQETFVGDQVLEIIPSHEEQIRTLLQLEAEEHLELDFWKSPTIPGETVHVRVPFASIQAVKVFLESQGIDYSIMIEDVQVLLDQEREEMLFNQQRERGGNFNFEAYHTLEEIYQEMDNLVAENPGLVSKVNLGSSFENRPMNVLKFSTGGDKPAIWLDAGIHAREWVTQATALWTANKIASDYGTDPAITSLLNTLDIFLLPVTNPDGYVFSQTTNRMWRKTRSKRSGSGCVGVDPNRNWDANFGGPGASSSPCSDSYHGPKPNSEVEVKSIVDFIKSHGKVKAFITLHSYSQLLMFPYGYKCTKPDDFNELDEVAQKAAQALKRLHGTSYKVGPICSVIYQASGGSIDWAYDLGIKYSFAFELRDTAFYGFLLPAKQILPTAEETWLGLKTIMEHVRDHPY
Protein: Carbamoyl phosphate synthase small chain (EC 6.3.5.5) (Carbamoyl phosphate synthetase glutamine chain) (P38098)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Carbamoyl phosphate synthase large chain
- Aspartate carbamoyltransferase catalytic subunit
- Ornithine carbamoyltransferase, anabolic
- Dihydroorotase-like protein
- Amidophosphoribosyltransferase
- Dihydroorotase
- Uncharacterized membrane protein PA4757
- Orotate phosphoribosyltransferase
- Phosphoribosylformylglycinamidine synthase
- Argininosuccinate synthase
Sequence:
MTKPAILALADGSIFRGEAIGADGQTVGEVVFNTAMTGYQEILTDPSYAQQIVTLTYPHIGNTGTTPEDAEANRVWAAGLIIRDLPLIASNWRSKQSLPDYLKANGTVAIAGIDTRRLTRILREKGSQNGCILAGADATEERALELARAFPGLKGMDLAKEVTTAERYEWRSSVWNLESDSHPEIPAGELPYHVVAYDYGVKLNILRMLVARGCRLTVVPAQTPASEVLALNPDGIFLSNGPGDPEPCDYAIQAIREFLDTEIPVFGICLGHQLLALASGAKTLKMGHGHHGANHPVQDLDSGVVMITSQNHGFAVDESTLPDNLRATHKSLFDGTLQGIERTDKVAFSFQGHPEASPGPHDVAPLFDRFISAMAERR
Protein: NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) (Q6A037)
Organism: Mus musculus (Mouse)
Function: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines. Acts as a restriction factor against some viruses: restricts viral replication by binding to mRNA viruses and mediating their degradation via its ribonuclease activity (By similarity). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:32971525}. Nucleus {ECO:0000269|PubMed:11717310}. Nucleus, nucleolus {ECO:0000269|PubMed:20233849}. Nucleus, PML body {ECO:0000269|PubMed:20233849}. Note=Primarily localizes to the nucleolus (PubMed:20233849). Also localizes to the PML nuclear bodies, when desumoylated (PubMed:20233849). {ECO:0000269|PubMed:20233849}.
Interaction partners:
- NF-kappa-B essential modulator
- Caspase-8
- E3 ubiquitin-protein ligase NEDD4
Sequence:
MAARVVLDEFTAPAEKAALLERSRGRIEALFGVGLAVLGALGAEEPLPARIWLQLRGAQEAVHSAKEYIKGICEPELEEKECYPKAMHCIFVGAQSLFLKSLIQDTCADLCVLDTGLLGIRGSAEAVVMARSHIQQFVKLFESNENLPSNQRESEIKREFRQFVEAHADSYTMDLLILPTSLKKELLSLTQGEESLFETDDDVITVGDVRPPEYTQSAATGPSSARDEVVVQEDSRNKARTPVSELTKHMDTVFSSSPDVLFVPVNGLSPDEDALSKDRVCHKRRSSDTEERHTKKQFSLENVPEGELLPDGKGSAGNEVIDLSDPASNSTNLSPDGKDTTEEMEYNILVNFFKTMGYSQEIVEKVIREYGPSTEPLLLLEEIEKENKRLQEDRDFPPCTVYPDASQSRNAGVGSTTNELTADSTPKKAQSHTEQSMVERFSQLPFKDSKHCTSNCKVNSFRTVPVGQKQEIWGSKQNSSCTVDLETDGHSASAASASPKDISFVSRGASGHQQRNPAFPENGFQQQTEPLLPNNTKPACEKRSGSCSSPQPKPNYPPLSPPLPLPQLLPSVTEARLGGSSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRADLKHIVIDGSNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNITEQHFLTQLQELGILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVTESVSWREIITKRLLQYTFVGDIFMVPDDPLGRNGPRLEEFLRKEAFLRHMQPLLNALPSVGTFDPGFRSPSTQVANNSHQPPPRIQTSSSPWLPQQSHFTALATLPSMQQNPPLPAQRSSAETSELREALLKIFPDSEQKLKIDQILAAHPYMKDLNALSALVLD
Protein: Tubulin alpha 1b (F8VVB9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQL
Protein: Arachidonate 15-lipoxygenase type B (I3L1D5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI
Protein: Protein RADIALIS-like 4 (AtRL4) (Protein RAD-like 4) (Q1G3C4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
Interaction partners:
- DNA repair protein RAD4
- At3g16350
- Probable mitochondrial import inner membrane translocase subunit TIM21
- DNA repair protein UVH3
- DNA repair protein RAD5A
Sequence:
MASSSMSTSSWTAREDKQFEMALAKFDKDTPDRWQKIARAVGGKSTEEVKRHYELLLRDVNDIESGRYPQPRYRNTN
Protein: Septation ring formation regulator EzrA (O34894)
Organism: Bacillus subtilis (strain 168)
Function: Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22882210, ECO:0000269|PubMed:24222488, ECO:0000305|PubMed:10449747}; Single-pass membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:22882210, ECO:0000269|PubMed:24222488}; Single-pass membrane protein {ECO:0000255}. Note=Cell membrane associated, also colocalizes with FtsZ to the nascent septal site (PubMed:10449747). Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion (PubMed:22882210, PubMed:24222488). {ECO:0000269|PubMed:10449747, ECO:0000269|PubMed:22882210, ECO:0000269|PubMed:24222488}.
Interaction partners:
- Cell division protein FtsA
- Cell division protein FtsZ
- Cell division protein SepF
- Cell division protein ZapA
- Cell cycle protein GpsB
- Cell division protein DivIB
- Penicillin-binding protein 1A/1B
- Penicillin-binding protein 2B
- Cell division protein DivIC
- Cell division protein FtsL
Sequence:
MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSIVEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKANQVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHLYGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKLLADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDIDEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETELVKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIEEVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLENAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFGNRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA
Protein: Lamin-B2 (B3DFN3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}.
Interaction partners:
- Emerin
- Lamin B receptor.
- Caspase 6, apoptosis-related cysteine peptidase a
- Caspase 6b.1, apoptosis-related cysteine peptidase
- SUN domain-containing protein 1
- trypsin
- Granzyme 3, tandem duplicate 3
- Granzyme 3, tandem duplicate 4
- Granzyme 3, tandem duplicate 2.
- Barrier-to-autointegration factor-like protein
Sequence:
MATATPSRASAAQTPLSPARISRLQEKEELRALNDRLAVYIDRVRALELENDRLQFKVSEKEEVTTREVSGIKSLYEAELADARRVLDETARERAKLQIELGKVNSELEEVTRNYKKKDGDLAAALVRIKDLEAQYNKNEAALNTALSENASLSAELADLKAQLAKAEDAHGVAKKQLEVETLMRVDLENRCQSLTEELEFRKSMFDEEVRETRRRHEKRMVEVDSGMQQDYEFKLSQALQDLRKQHEEQVQIYKEELQHTFKAKLDNAKVSSDLNDKAVLTAREELQEAHVRIEGLSYQLSALQKQASAAEERIRELEGLLSSDRDKYRRQLDAKEREMAEMRECMQQQLNEYQELLDVKLALDMEINAYRKLLEGEEDRLKLSPSPSSRVTVSRTTASSTSASSRSSRAKRKRVELEESSTAGPKVQISQQAEASGSVSIEEIDLEGKSVTLRNNSDKDQSLGSWRLKRQIGDGEEIVYKFSPKFVLKAGQTVTVWSADAGMSHSPPSDLLWKSQSSWGTGENILTLLVNSSGEDVAKRTVTKSVIEMENGDDEEGDFGDEDLFHQQGDPKTQRARECAVM
Protein: Cdr3p (A0A1D8PLV0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Op4p
- ATP-binding cassette transporter
Sequence:
MLGVIGAAPGTQANQDYFETWRNSPEYRAVQNELHRLEEMPGLASGEKEPDTNQAYAASFWKQYIFVVHRLFQQYWRTPSYIYSKFAMAVLCSLFNGFTYYKSQNSMQGLKNQMLSIFSMFVVLTTLAQQYVPLFVTQRDLYEARERPSKTFSWLAFIAAQITAEIPYQVLAATISFFSWYYPVGLYRNAVYSGAVTHRGVLMWLIMTLMFIYSSTLAQFCISWNQLADYAANWISLLLTISMIFCGVIATKDSMPKFWVFLYRCTPLTYLTSAMMSIGLGDSFVKCAPTEILTFPPQTPGVQKCQDYMGAYISIAGGYLLNPEATDNCKFCIMDKTNQFLDFMNISIHNFGRDTGIFIVFIVFNMAATVFSYWLFRVPKGNREKGSFFDKLPFLNGGGDTNHENV
Protein: Poly(A) RNA polymerase GLD2 (mGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Q91YI6)
Organism: Mus musculus (Mouse)
Function: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16325797}. Nucleus {ECO:0000269|PubMed:16325797}.
Interaction partners:
- Symplekin
- Cytoplasmic polyadenylation element-binding protein 1
- Poly
- Poly
- Poly
- Poly
- Poly
- Neuroguidin
- 5'-3' exoribonuclease 2
- Polyadenylate-binding protein 1-like
Sequence:
MFPNSILGRPPFTPTHQQHNNFFALSPTLYSHQQLIDAQFNFQNVDLSRAVSLQPLTYGTVSPIQTSTSPLFRGRKRISDEKAFPLDGKRQRFHSPHQEPTIINQLVPLSGDRRYSMPPLFHTHYIPDIVRCVPPLREIPLLEPREITLPEAKDKLSQQILELFETCQQQASDLKKKELCRAQLQREIQLLFPQSRLFLVGSSLNGFGARSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNTVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHDINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSTSVQLHLVHHAPCNVPPYLSKNESSLGDLLLGFLKYYATEFDWNTQMISVREAKAIPRPDDMEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWQRLKNKRDLNSVLPLRAATLKR
Protein: DNA polymerase IV (Pol IV) (EC 2.7.7.7) (Q72MY7)
Organism: Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01113}.
Interaction partners:
Sequence:
METRKIIHVDMDAFYASVEQRDFPEYKGKPLIVGGPPNSRSVVSAASYEARKFGVRSAMPCSKAAQLAPQAIFVFPRFEVYKEVSKQIREIFLEYTDLVEMLSLDEGYLDVTFNKKNIPFAVTIAKEIRTEIFKRTELTASAGVGNSKFISKLASEKNKPNGLTVVLPDDVISFIDPLPVSSFHGVGKVTARKMKELGIYTGKDLRTKSIDELVQHFGKMGIYYYKISRGEDERMVQSSRERKSLGAESTFDRDKLDYDDLLKQLKDVAVVVERRLEKKDFAGKTLTLKIKFYDFSLKTRSKTLSEPIFKADELYSTAIELFEEFFEIKYGKKSAIKAIRLLGISLSHPNSENEDPNLFLNL
Protein: Proteasomal ubiquitin receptor ADRM1 homolog (Q556N5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme uchl5 at the 26S proteasome and promotes its activity (By similarity). Plays a role in the transition from growth to differentiation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q16186}. Nucleus {ECO:0000250|UniProtKB:Q16186}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 1
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 2
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome non-ATPase regulatory subunit 3
- 26S proteasome regulatory subunit 10B
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome non-ATPase regulatory subunit 11
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome regulatory subunit 7
Sequence:
MNRPPQDVEFKAGKAKLTGTTVTSDSRKGYLKFGVTPEGLTCVQWRPRDSSAYEDEFYFAPGESKFIKVPACKTGRMYYLNFSGSDQKEFYWLQEANVEGDAKIEKALKVIESYIPDDDDDEEMVVDTPPPTTTIKQEPPKNPTINEVSLSQPKPTTTPPPSATNLDFIKDLFSNLPTQPKQPQITLGKILTAENLIPFLRENPEIKKDLIQYLPEEYQKDENMINEVLHSAQFLQSIETLDYAIHEGHGPEIVSLLGYEPSIASQRGVEGFLTNIQEGTNKKKNNK
Protein: RK2 (Q26441)
Organism: Drosophila sp. (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MEHDSFDDPIFGEFGGGPLNPLGAKPLMPTTTAMHPVMLGSVHELCSQQQQQQQQQRLPDCNTILPNGGGGGAGSGGAGGSPNYVTKLDFVNKMGCYSPSQKYEYISAPQKLVEQQQQQQHHHQHHQHYTATPPPSHNGILLHKQSSQQQQQQQQQLVGILDYHPLNGKLDYSSSPKDQYEPQQLQHLYGGSPHHLDHLDHGSDGLLQDSSPVMINGGSAGGKLKKPDEMCSQLEAGGAGVTPPSSSSTVVNGTTNGTGNANSSSSAGVGIQGAAGTAGGVAAPAAKKDGSSSKKKGDPNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFAREELAIKLNLSESRVQVWFQNRRAKWRKHEPPRKTGYIKTSTPPTATLNPGTLAPPFTSYPQTTTVTPPGSMDSWTSYQTPYELTPQFSLLSPAASPYGTYSGQYGAYVHESQLFPMRHYEYGSPTRMEMGATTGSVAGNGDESVANGGSYQTAELQTAQQQQLADGTLVTVHAHQQQQQQQQQLNGKYLSAEEAKYVHLQCHQSGGGLELSPGASCHLVEAQGQHYVTTATGGAASAGGTSSDDNDSGGMQTVIKSEEVSQQQQQQQGQSYVLPPFLH