wanglab/gogpt-training-data huggingface dataset:
Protein: WEB family protein At3g02930, chloroplastic (Q9M8T5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
Sequence:
MASKIKNGLSDTTLRKSSSTSLRVPRLTRIVTKPDSNSPSPTQQQSRLSFERPSSNSKPSTDKRSPKAPTPPEKTQIRAVRVSESQPQSVQIKEDLKKANELIASLENEKAKALDQLKEARKEAEEASEKLDEALEAQKKSLENFEIEKFEVVEAGIEAVQRKEEELKKELENVKNQHASESATLLLVTQELENVNQELANAKDAKSKALCRADDASKMAAIHAEKVEILSSELIRLKALLDSTREKEIISKNEIALKLGAEIVDLKRDLENARSLEAKVKELEMIIEQLNVDLEAAKMAESYAHGFADEWQNKAKELEKRLEEANKLEKCASVSLVSVTKQLEVSNSRLHDMESEITDLKEKIELLEMTVASQKVDLEKSEQKLGIAEEESSKSEKEAEKLKNELETVNEEKTQALKKEQDATSSVQRLLEEKKKILSELESSKEEEEKSKKAMESLASALHEVSSESRELKEKLLSRGDQNYETQIEDLKLVIKATNNKYENMLDEARHEIDVLVNAVEQTKKQFESAMVDWEMREAGLVNHVKEFDEEVSSMGKEMNRLGNLVKRTKEEADASWEKESQMRDCLKEVEDEVIYLQETLREAKAETLKLKGKMLDKETEFQSIVHENDELRVKQDDSLKKIKELSELLEEALAKKHIEENGELSESEKDYDLLPKVVEFSEENGYRSAEEKSSKVETLDGMNMKLEEDTEKKEKKERSPEDETVEVEFKMWESCQIEKKEVFHKESAKEEEEDLNVVDQSQKTSPVNGLTGEDELLKEKEKKKKKTLFGKVGNLLKKKGPVNQK
Protein: Tubulin gamma-1 chain (Gamma-1-tubulin) (P38557)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000305|PubMed:22144887}. Cytoplasm {ECO:0000269|PubMed:22144887}. Nucleus {ECO:0000269|PubMed:22144887}. Cytoplasm, cell cortex {ECO:0000269|PubMed:22144887}. Note=Present in discrete dots in the cytoplasm and cell cortex.
Interaction partners:
- Gamma-tubulin complex component 2
- Gamma-tubulin complex component 4
- Gamma-tubulin complex component 3
- Gamma-tubulin complex component
- Gamma-tubulin complex component
- Spc97 / Spc98 family of spindle pole body
- Protein NEDD1
- Spindle pole body component
- Mitotic-spindle organizing protein 1B
- Protein MOR1
Sequence:
MPREIITLQVGQCGNQIGMEFWKQLCLEHGISKDGILEDFATQGGDRKDVFFYQADDQHYIPRALLIDLEPRVINGIQNGDYRNLYNHENIFVADHGGGAGNNWASGYHQGKGVEEEIMDMIDREADGSDSLEGFVLCHSIAGGTGSGMGSYLLETLNDRYSKKLVQTYSVFPNQMETSDVVVQPYNSLLTLKRLTLNADCVVVLDNTALGRIAVERLHLTNPTFAQTNSLVSTVMSASTTTLRYPGYMNNDLVGLLASLIPTPRCHFLMTGYTPLTVERQANVIRKTTVLDVMRRLLQTKNIMVSSYARNKEASQAKYISILNIIQGEVDPTQVHESLQRIRERKLVNFIEWGPASIQVALSKKSPYVQTAHRVSGLMLASHTSIRHLFSKCLSQYDKLRKKQAFLDNYRKFPMFADNDLSEFDESRDIIESLVDEYKACESPDYIKWGMEDPEQLMTGEGNASGVVDPKLAF
Protein: DEAD/DEAH box RNA helicase family protein (F4HYE4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGSRVPIETIEEDGEFDWEAAVKEIDLACLKTTNASSSSSSHFTPLANPPITANLTKPPAKRQSTLDKFIGRTEHKPENHQVVSECGVNDNDNSPLVGIDPEAAKTWIYPGFVPLRDYQFAITKTALFSNTLVALPTGLGKTLIAAVVMYNYFRWFPQGKIVFAAPSRPLVMQQIEACHNIVGIPQEWTIDLTGQTCPSKRAFLWKSKRVFFVTPQVLEKDIQSGTCLTNYLVCLVIDEAHRALGNYSYCVVVRELMAVPIQLRILALTATPGSKTQAIQGIIDNLQISTLEYRNESDHDVCPYVHDRKLEVIEVPLGQDADDVSKRLFHVIRPYAVRLKNFGVNLNRDIQTLSPHEVLMARDKFRQAPLPGLPHVNHGDVESCFAALITLYHIRKLLSSHGIRPAYEMLEEKLKEGPFARLMSKNEDIRMTKLLMQQRLSHGAPSPKLSKMLEILVDHFKVKDPKTSRVIIFSNFRGSVRDIMNALSNIGDMVKATEFIGQSSGKTLKGQSQKIQQAVLEKFRAGGFNVIVATSIGEEGLDIMEVDLVICFDANVSPLRMIQRMGRTGRKNNGRPLLVLACEGSEKNSYMRKQASGRAIKKHMRNGGTNSFNFHPSPRMIPHVYKPEVQHVEFSIKQFVPRGKKLQEEYATETPAFQKKLTPAETHMLAKYYNNPDEEKLRVSLIAFPHFQTLPSKVHKVMHSRQTGMLIDAMQHLQEPTFSEQSKSFFTEFRAPLGEREELDTGLRVTNDPKDLHSVRDLEVNTSQRKAKQVESPTSTLETTEKDYEESSPTHRYLFSSECASVDTLGNVFVMPVPLLFFPNVLESDNTPLPKTEKQHSCRNTSHIDLVPVDTSEKHRQDNISCKLKERFSPDGASETLETHSLVKRNSTRVGEDDVANSVGEIVLSSDEDDCEGLELSPRLTNFIKSGIVPESPVYDQGEANREEDLEFPQLSSPMRFSNELAGESSFPERKVQHKCNDYNIVSTTTELRTPQKEVGLANGTECLAVSPIPEDWRTPLANLTNTNSSARKDWRVSSGEKLETLRQPRKLKRLRRLGDCSSAVKENYPGITEADHIRSRSRGKKHIRVKWKSAESWFTLSSVAFALVTKKKKMIMDDDVQVFIDEEAEVSSGAEMSADENEDVTGDSFEDSFIDDGTMPTANTQAESGKVDMMAVYRYIQPKISFFYCEVNELIKNHKVSFHRRSLLSQSPLPARFRDLAASSLSPYSAGPLTRINESRSDSDKSLSSLRTPKTTNSESNQDAMMIGNLSVVQISSDSRKRKFSLCNSANAPVINLESKFAAHAQATEKESHEGVRSNAGALEYNDDDDDAFFATLDFDAMEAQATLLLSKQRSEAKEKEDATVIPNPGMQRSDGMEKDAPSFDLGLW
Protein: Serine/threonine-protein phosphatase 4 catalytic subunit B (PP4C-B) (EC 3.1.3.16) (A9JRC7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Protein phosphatase that regulates many processes such as microtubule organization at centrosomes.
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein phosphatase 4 regulatory subunit 2-B
- Immunoglobulin
- Serine/threonine-protein phosphatase 2A activator
- Serine/threonine-protein phosphatase 4 regulatory subunit 3
- Serine/threonine-protein phosphatase 4 regulatory subunit 2-A
- Protein phosphatase 4, regulatory subunit 3B.
- Transcription elongation factor SPT5
- Replication protein A 70 kDa DNA-binding subunit
- Aspartate beta-hydroxylase domain-containing protein 2
- Protein yippee-like 3
Sequence:
MGDMSDLDRQIDQLRRCELIKENEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKEFIIFEAAPQETRGIPSKKPVADYFL
Protein: Protein NDRG2 (Antidepressant-related protein ADRG123) (N-myc downstream-regulated gene 2 protein) (NDRG1-related protein) (Q8VBU2)
Organism: Rattus norvegicus (Rat)
Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor (By similarity). May be involved in dendritic cell and neuron differentiation.
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone.
Interaction partners:
- N-myc proto-oncogene protein
Sequence:
MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSQDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRSLITHAPNLENIELYWNSYNNRRDLNFERGGEMTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFVQGMGYMASSCMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC
Protein: Uncharacterized PPE family protein PPE13 (P9WI35)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein Rv2082
- PE-PGRS family protein PE_PGRS28
- PE-PGRS family protein PE_PGRS2
- Probable membrane protein
- PE-PGRS family protein PE_PGRS15
- PE-PGRS family protein PE_PGRS30
- PE-PGRS family protein PE_PGRS48
- Uncharacterized protein Rv2209
- PE-PGRS family protein PE_PGRS43
- PE-PGRS family protein PE_PGRS23
Sequence:
MNFMVLPPEVNSARIYAGAGPAPMLAAAVAWDGLAAELGMAAASFSLLISGLTAGPGSAWQGPAAAAMAAAAAPYLSWLNAATARAEGAAAGAKAAAAVYEAARAATAHPALVAANRNQLLSLVLSNLFGQNLPAIAATEASYEQLWAQDVAAMVGYHGGASTVASQLTPWQQLLSVLPPVVTAAPAGAVGVPAALAIPALGVENIGVGNFLGIGNIGNNNVGSGNTGDYNFGIGNIGNANLGNGNIGNANLGSGNAGFFNFGNGNDGNTNFGSGNAGFLNIGSGNEGSGNLGFGNAGDDNTGWGNSGDTNTGGFNSGDLNTGIGSPVTQGVANSGFGNTGTGHSGFFNSGNSGSGFQNLGNGSSGFGNASDTSSGFQNAGTALTRASSTWADSPRAWPIRAPSRLQVWRTRATTARECSIRVIISRVSSTGAPPQKKVGNSG
Protein: Aquaglyceroporin (Small solute channel), putative (Q388I6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MQSQPDNVAYPMELQAVNKDGTVEVRVQGNDDSSNRKHEVAEAQEEVPGGINFWAPRELRLNYRDYMGELLGTFVLLFMGNGVVATVIIDGKLGFLSITLGWGIAVTMALYVSLGISSGHLNPAVTVGNAVFGDFPWRKVPGYIAAQMLGAFLGAACAYGVFADLLKAHGGGELIAFGEKGTAGVFSTYPRDSNGLFSCIFGEFICTAMLLFCVCGIFDPNNSPAKGHEPLAVGALVFAIGNNIGYSTGYAINPARDFGPRVFSSFLYGGKVFSHANYYFWVPLVIPLFGGIFGLFLYKYFVPH
Protein: SrfA-induced gene F protein (Q6TMK2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Peptidase C1A papain C-terminal domain-containing protein
- Prespore-specific protein E
- Peptidase A1 domain-containing protein
- Heat shock protein DDB_G0280215
- Putative uncharacterized protein DDB_G0290419
- Putative uncharacterized protein DDB_G0284619
Sequence:
MVEINDIIKLYTVHPNLDLIDKNFAEDCEFEAFNIPSFKVKGIEAIHEIFKAIGFYAKDIKISKYNYTHSSHCIVLNTQQEITFNILPFVKFNYRMIINIHKNKENKITKFEEITDLESVIQNIPLANYGYFNIIKPALGYLMVKAGSYNRGFQNNGPNKIQATMERLSDNFVEKKEVNYSEPLIKLSKNFNGVTHQDKIDNMDEELFNSKKIDIKDGSNNAWKKPLNLHQ
Protein: Rap1 GTPase-activating protein (A0A8I6AU92)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAQPRPPAPQGRPRRGSLPAGAGWQNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGMESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDAVKSGDPACPEIKIQLETSEQHTPQMGC
Protein: Procyclin associated gene 3 (Q581G1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFRKSSELEGKCSSSPFVRLDSHTEASTKQAATLLLTFWFILFPYFSVGVFLLPPLGIGHSHMKALASAAKGGSVWYFLWRHLSSFPFRPPLFPWRKASGTVLPDDLCPVRSIMNNSYKSVCRYGGGYFPNRFGCFYYFAGRFKVGNSVHFQKNCDSYIWFYMEGGRAENVYVLAWMSRKINSSFRVFSVHYVIYGLAFRFV
Protein: Glutathione S-transferase D2 (EC 2.5.1.18) (Q9VG98)
Organism: Drosophila melanogaster (Fruit fly)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May be involved in detoxification.
Interaction partners:
- Glutathione S transferase D10, isoform A
- Glutathione S transferase D8
- Glutathione S-transferase D5
- Glutathione S-transferase D1
- Glutathione S-transferase D4
- Glutathione S-transferase D7
- FI01423p
- Glutathione S transferase D9, isoform A
- Bifunctional glutamate/proline--tRNA ligase
- Glutathione S transferase E7
Sequence:
MDFYYMPGGGGCRTVIMVAKALGLELNKKLLNTMEGEQLKPEFVKLNPQHTIPTLVDNGFSIWESRAIAVYLVEKYGKDDYLLPNDPKKRAVINQRLYFDMGTLYESFAKYYYPLFRTGKPGSDEDLKRIETAFGFLDTFLEGQEYVAGDQLTVADIAILSTVSTFEVSEFDFSKYSNVSRWYDNAKKVTPGWDENWEGLMAMKALFDARKLAAK
Protein: Spore germination protein 270-11 (P22698)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Endoglucanase
- Spore germination protein 2
- Spore germination protein 1
- Stalk-specific protein A
- Spore germination protein 3
Sequence:
MKNIYSLFLLFALISATFANNAFIVHWNSDSISKKLTGQIGDTISFYTSDGNSHDVKSSDGSVSSSVFSGSLTNPGIFKVTLTKEGNIEFTSSYDEGLSATIVVSSGGQIPITTTSSTTTDGSSTPSTPTSTTSASTTTSGGSATTTTGEPITDGSNGGASSTTGNSGTTGSATTTTSSSSDNSDGSVGTSTTTSPAITTSSGSIIDPTSPPTTDSSSNSGGYGSSSSIENGVECLLTITQDAFDSWTYDNIIYTVYQVNLTNIGTLSVESVILTPNDNSLIYHTWELVYDGTSLTLPTYRKAGPINPEETIIFGYISRNSTDVTFALSPTCSDSSSPTPTPTETPTETPTETPTETPTETPTETPTETPTETETPTPTPSSSSSDVDSGSSSEIETPTPTETDTPTPTPSSSSSEGSGSSSETQPPITPPPTTGTSCLAQVQQKVINSWINGEVDHYIQVEATIVNQGSTPISSFNFYSDAEQIWSVEKTGTNTYKLPSWFSTIPVGGSHTFGYIVKSAELSDLEGVQYTC
Protein: Neuropeptide-Like Protein (Q22739)
Organism: Caenorhabditis elegans
Interaction partners:
- Neuropeptide-Like Protein
- Neuropeptide-Like Protein
- Neuropeptide-Like Protein
- Neuropeptide-Like Protein
- Neuropeptide-Like Protein
- Serpentine Receptor, class T
- Neuropeptide-Like Protein
- Neuropeptide-Like Protein
Sequence:
MRATLVLFALLCAVYSEAVPLQVYRPDESSAVDVVVLENSPELYDSEDEDEWKQEEEFTEGAMGKRSIALGRSGFRPGKRSMDNFHTVDVSDLIMKRSMAMGRLGLRPGKRSMAYGRQGFRPGKRSMAYGRQGFRPGKRSMAYGRQGFRPGKRSNDMKEVFPQHVPEIYII
Protein: Interleukin 34 (Interleukin-34 isoform X1) (Interleukin-34 precursor) (Si:ch211-239j19.3 protein) (B3DLJ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Macrophage colony-stimulating factor 1 receptor
- Colony-stimulating factor 1b
- Colony-stimulating factor 1 receptor, b
- Colony-stimulating factor 1a
- Protein tyrosine phosphatase receptor type Z1b.
- Mast/stem cell growth factor receptor kita
- Si:zfos-1069f5.1.
- Mast/stem cell growth factor receptor
Sequence:
MVQSECWLLRGLLGFICLLPVCSSAAPDLCGPLKTVQDSLNATLRRRYMKMHFPINYTVQVRYEEVFRLRNISRLVNTSNEEEPVLPRDLQDLWLYVSQQGIKKVLRVLPERHPTRRKYLSDLENLFKKFETVFKEGNHEDQENVRERPESLQTIWDHLTEQDYKGWKSVTPKSILDNCYRTMLCLFKECFTKEDDNYDYCEVYNRRKERKTT
Protein: Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) (P56818)
Organism: Mus musculus (Mouse)
Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P56817}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19074428}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P56817}. Endosome {ECO:0000269|PubMed:19074428}. Late endosome {ECO:0000269|PubMed:25592972}. Early endosome {ECO:0000269|PubMed:25592972}. Cell surface {ECO:0000269|PubMed:26467158}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P56817}. Membrane raft {ECO:0000269|PubMed:19074428}. Lysosome {ECO:0000269|PubMed:25592972}. Recycling endosome {ECO:0000269|PubMed:23931995}. Cell projection, axon {ECO:0000269|PubMed:29325091}. Cell projection, dendrite {ECO:0000269|PubMed:29325091}. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine which blocks targeting to late endosomes and lysosomes (PubMed:25592972). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (By similarity). {ECO:0000250|UniProtKB:P56817, ECO:0000269|PubMed:25592972}.
Interaction partners:
- Amyloid-beta precursor protein
- Reticulon-4
- Reticulon-3
- Presenilin-1
- Beta-secretase 2
- ADP-ribosylation factor-binding protein GGA1
- Nicastrin
- Disintegrin and metalloproteinase domain-containing protein 10
- Cyclin-dependent kinase 5
- Gamma-secretase subunit PEN-2
Sequence:
MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK
Protein: Lipoxygenase 2, chloroplastic (AtLOX2) (EC 1.13.11.12) (P38418)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: 13S-lipoxygenase that can use linolenic acid as substrates. Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. Required for the wound-induced synthesis of jasmonic acid (JA) in leaves.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18431481}. Cytoplasm. Note=The unprocessed form is cytoplasmic whereas the cleaved form is chloroplastic.
Interaction partners:
- Allene oxide synthase, chloroplastic
- Probable inactive linolenate hydroperoxide lyase
- Alpha-dioxygenase 1
- Alpha-dioxygenase 2
- Phospholipase A
- Allene oxide cyclase 1, chloroplastic
- Allene oxide cyclase 2, chloroplastic
- Allene oxide cyclase 4, chloroplastic
- Allene oxide cyclase 3, chloroplastic
- 12-oxophytodienoate reductase 3
Sequence:
MYCRESLSSLQTLNVAKSLSSLFPKQSALINPISAGRRNNLPRPNLRRRCKVTASRANIEQEGNTVKEPIQNIKVKGYITAQEEFLEGITWSRGLDDIADIRGRSLLVELISAKTDQRITVEDYAQRVWAEAPDEKYECEFEMPEDFGPVGAIKIQNQYHRQLFLKGVELKLPGGSITFTCESWVAPKSVDPTKRIFFSDKSYLPSQTPEPLKKYRKEELETLQGKNREEVGEFTKFERIYDYDVYNDVGDPDNDPELARPVIGGLTHPYPRRCKTGRKPCETDPSSEQRYGGEFYVPRDEEFSTAKGTSFTGKAVLAALPSIFPQIESVLLSPQEPFPHFKAIQNLFEEGIQLPKDAGLLPLLPRIIKALGEAQDDILQFDAPVLINRDRFSWLRDDEFARQTLAGLNPYSIQLVEEWPLISKLDPAVYGDPTSLITWEIVEREVKGNMTVDEALKNKRLFVLDYHDLLLPYVNKVRELNNTTLYASRTLFFLSDDSTLRPVAIELTCPPNINKPQWKQVFTPGYDATSCWLWNLAKTHAISHDAGYHQLISHWLRTHACTEPYIIAANRQLSAMHPIYRLLHPHFRYTMEINARARQSLVNGGGIIETCFWPGKYALELSSAVYGKLWRFDQEGLPADLIKRGLAEEDKTAEHGVRLTIPDYPFANDGLILWDAIKEWVTDYVKHYYPDEELITSDEELQGWWSEVRNIGHGDKKDEPWWPVLKTQDDLIGVVTTIAWVTSGHHAAVNFGQYGYGGYFPNRPTTTRIRMPTEDPTDEALKEFYESPEKVLLKTYPSQKQATLVMVTLDLLSTHSPDEEYIGEQQEASWANEPVINAAFERFKGKLQYLEGVIDERNVNITLKNRAGAGVVKYELLKPTSEHGVTGMGVPYSISI
Protein: Pebble, isoform B (Q8IQ97)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Kinesin-like protein
- Rac GTPase-activating protein 1
- Ras-like GTP-binding protein Rho1
- Anillin
- Cdc42 homolog
- Rho-type guanine nucleotide exchange factor, isoform F
- GTPase-activating protein RacGAP84C
- Chromosome associated protein G, isoform F
- Protein diaphanous
- RE25723p
Sequence:
MEMETIEEQSKCEMSITTLPTRICLVGGVGQDADTLQAAESFGLPIVTSDTGLDILGESSDWRTFYVLDDFEGASFEAIHKQKECILGPPALKYAAEMKQTLGQNSRPIYNYAMRGVVTCFTGIRKKDELTKLVNLIHSMGGCIKKDLNTKTTHLICNHSGGEKYQYAKTFRLTVVRPAWVFAAWADRNSLEFDATQENFTKTHRLKAFEGQKICFFGFPVEEHQHMVDVLLENGGVCAELDDPECSHVVMPNTGAVFTSTSTSTDTNPSTLINPPESQVPGSSSASQAGEEEQRKAEHLEQAEIKKMEYSHAETDNGMSLDIDQEQKENQGIEDEDDIHFDERLFVEAADIINHGEDQLPESDEEDLEEEQKPKVEEVLKEQEVEEDVQASTPKTSKIRTSLKAATPLSSPEMDGIALDFESTTQNISPILKAIDECDLETDDLPPSENDLKRKRESFDNVSLMSVDSFALPASTKKPKLIRTGSISRTLRRSVSFVAEPLMKTLRPRRSSVADASSFVGSEAADNSICSLASSINLTLNDSIRKPVKEKLRSFCGRITRSSSRRHDRGVDGTPECTTLLDSGFKTPKAPKLRSTATPKTAKRLFGPVSGVVSALTLTNPSTPTPNPNPNTNCTATLDVNDTSIHTFAFCAAAVTPAMPPSSSSSSSSPILSTSIAVHSSVQVIKSPEESTTRRNSPAPIEEPMAMVVDEHTTLTKPEPKNNHTHILKSDWFWYTIQNGYANEMDYLFGDYLDSITNTPNTDRRDSLPISFNKRKRKRFSQRIQLEGTPLGSGKRRSSVSDAGLLSVSNSLFDCTTSPDKLESDKLLHAEPEASDATPAKKSMRFNHFMDFYTTESNYVGILDTILNLFKNKLEELAETNDPLLNKSEIKTIFGNFLPIHEVHQSMLEHLRKLHANWREDCLIGDIIIQHRDELIKAYPPYVNFFEQMKEQLQYCDREYPRFHAFLKINQTKPECGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHGRLEEALKAIKQVTLHINEDKRRTESRMAIFDIFNDIEGCPAHLVSSNRSFILKCEVNELSDSLSGRGDSLVLYLFSDSIELCKRRSKGFNTAKSPSTAKTHKHLKLISLNTIRLVIDISDSPRAFGLLLRGDKEKLYTFTISDEETDKSVYVKKLCNQIAAHTCRTDADKLLICRTSQELEVDISDVNVSTLSKAFKLAAKTRLKVGRAFSFNKTPNKLKRAVSTMMTSPFGSTNSLTPASQLAQMRLASCTNINEVDDEDCASMRSSSPSTQSEMLVVPPLSVQPTRKNKAVVGRI
Protein: Uncharacterized protein At2g34160 (O22969)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alba DNA/RNA-binding protein
- AT3g07170/T1B9_17
- DEAD-box ATP-dependent RNA helicase 46
- Alba DNA/RNA-binding protein
- Putative RRM-containing protein family protein)
- Pre-mRNA cleavage factor Im 25 kDa subunit 2
- Alba DNA/RNA-binding protein
- THO complex subunit 4C
- At5g12410
- 26S proteasome non-ATPase regulatory subunit 7 homolog B
Sequence:
MEEITDGVNNMNLATDSQKKNRIQVSNTKKPLFFYVNLAKRYMQQYNDVELSALGMAIATVVTVTEILKNNGFAVEKKIMTSTVDIKDDARGRPVQKAKIEITLVKSEKFDELMAAANEEKEDAEAQVQN
Protein: Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7) (Q29450)
Organism: Bos taurus (Bovine)
Function: Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors. Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (By similarity). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (By similarity). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Rap guanine nucleotide exchange factor 4
- Protein kinase C delta type
- Guanine nucleotide-binding protein G
- Rap guanine nucleotide exchange factor 3
- apyrase
- Cancer-related nucleoside-triphosphatase homolog
- Cannabinoid receptor 1
- Bis
Sequence:
MPAKGRYFLNEGEEGPDQDALYEKYRLTSQHGPLLLMLLLVAIAACTTLIVITFSYGDPSRHRAVLGTAFFTLAMFVLLYALVYVECLDRRGLRISALLIWGCLVTLGYVLVFDFDSPRKDTLCLWGRCPSSSFVVFVVYTLLPFSMWGAVTAGLVSSISHLLVLAMHQEDFTSPVGLKLLATAVVFVCGNLTGAFHKHHMQDASHDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKERGDRRYLPDNNFHNLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPNHARNCVKMGLDMCEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPQPSQHNSKNKGNATLKMRASVRMTRYLESWGAARPFAHLNQRESVSSSETLVSHGRRPKAVPLRRHRTPDRSASPKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFSTFGSIFLEKGFEREYRLAPIPRVRYYFACASLVFVCILLIHVLLLYSMKTLGVSFGLVACVLGLVLGLCFADVFLRCCPALGKLRAIAESVETQPLLRVSLAILTIGSLLVIAVVNLPLMPFRDRGLTAGNETGLRAVSGWEMSPCYLLPYYTCSCILAFIACSVFLRMSLELKVVLLTVALVAYLVLFNVYPSWQWDCCGHSLGNLTGTNGTLSSSSCSWHLKTMTNFYLVLFYTTLIMLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVPSGPENQDLERQHAHIGIMVEFSTALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLIDVKGKGELRTYFVCTDTAKFQGLGLN
Protein: Ectonucleoside triphosphate diphosphohydrolase 6 (Q5QPI9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYGGSHLEREGTCLIPSVSDPGDTAAEQPLLMHGPHLRQPATPGVRLSQEQSAEAHSEN