wanglab/gogpt-training-data huggingface dataset:
Protein: Voltage-dependent L-type calcium channel subunit beta-4b isoform X2 (Voltage-dependent calcium channel beta 4 subunit) (T2B3N4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MYDNLYLHGFEDSEAGSADSYTSRPSDSDVSLEEERPEGGSQGRQEREQQAQLQLERAKAKAVAFAVKTNVSYCGALDEDVPVPGTAISFDAKDFLHIKEKFNNDWWIGRLVKEGCEIGFIPSPLKLENIRAQLEQKKSRVQGKQKQKVTEHVAPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRITITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLMKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHTSSSTPLNPLLGRNLGPAALAPYTTSAISGLQNQQGQKTRHANHTGDHSTPNERRNLMTSDENYHNERAHKGRNRGSSGSQHGGSGRDHHYMEEQQGYQDPYQDTYKPHRNRSSPGSYSQDSRHRL
Protein: Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) (P36590)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of dTMP to dTDP.
Interaction partners:
- Probable thymidylate synthase
- Deoxycytidylate deaminase
- Nucleoside diphosphate kinase
- Ribonucleoside-diphosphate reductase large chain
- Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
- Dihydrofolate reductase
- Ribonucleoside-diphosphate reductase small chain
- Adenylate kinase
- Golgi apyrase
- Putative cytidine deaminase
Sequence:
MSKQNRGRLIVIEGLDRSGKSTQCQLLVDKLISQHEKAELFKFPDRTTAIGKKIDDYLKESVQLNDQVIHLLFSANRWETIQYIYEQINKGVTCILDRYAFSGIAFSAAKGLDWEWCKSPDRGLPRPDLVIFLNVDPRIAATRGQYGEERYEKIEMQEKVLKNFQRLQKEFREEGLEFITLDASSSLEDVHSQIVDLVSNVNIHETLDVL
Protein: Bax inhibitor 1 (AtBI-1) (BI-1) (Q9LD45)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Suppressor of apoptosis. Modulator of endoplasmic reticulum stress-mediated programmed cell death. Involved in methyl jasmonate-induced leaf senescence through regulating cytoplasmic calcium level.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19054355}; Multi-pass membrane protein {ECO:0000269|PubMed:19054355}.
Interaction partners:
- Dihydroceramide fatty acyl 2-hydroxylase FAH1
- Cytochrome b5 isoform B
- Cytochrome b5 isoform E
- Cytochrome B5 isoform D
- Cytochrome B5 isoform C
- Cytochrome b5 isoform A
- Dihydroceramide fatty acyl 2-hydroxylase FAH2
- BI1-like protein
- bZIP transcription factor 28
- bZIP transcription factor 60
Sequence:
MDAFSSFFDSQPGSRSWSYDSLKNFRQISPAVQNHLKRVYLTLCCALVASAFGAYLHVLWNIGGILTTIGCIGTMIWLLSCPPYEHQKRLSLLFVSAVLEGASVGPLIKVAIDVDPSILITAFVGTAIAFVCFSAAAMLARRREYLYLGGLLSSGLSMLMWLQFASSIFGGSASIFKFELYFGLLIFVGYMVVDTQEIIEKAHLGDMDYVKHSLTLFTDFVAVFVRILIIMLKNSADKEEKKKKRRN
Protein: Centrosomal protein 170 (E7EMW0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPTSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREEVGDLHGEMHKLVDRVFDESLNFRKIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESKLRAESEVPIVKTSSMEISSILQELKRVEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHPAAVSAAAEFENAESEADFSIHFNRFNPDGEEEDVTVQE
Protein: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane phosphoprotein Cbp) (Q9JM80)
Organism: Rattus norvegicus (Rat)
Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10801129, ECO:0000269|PubMed:11859092}; Single-pass type III membrane protein {ECO:0000269|PubMed:10801129, ECO:0000269|PubMed:11859092}. Note=Present in lipid rafts.
Interaction partners:
- Tyrosine-protein kinase CSK
- Proto-oncogene tyrosine-protein kinase Src
- Proto-oncogene tyrosine-protein kinase LCK
- Tyrosine-protein kinase Fyn
- Tyrosine-protein kinase Lyn
- Megakaryocyte-associated tyrosine-protein kinase
Sequence:
MGPAGSALSSGQMQMQMVLWGSLAAVAMFFLITFLILLCSSCDRDKKPRQHSGDHESLMNVPSDKEMFSHSATSLTTDALASSEQNGVLTNGDILSEDSTMTCMQHYEEVQTSASDLLDSQDSTGKAKCHQSRELPRIPPENAVDAMLTARAADGDSGPGVEGPYEVLKDSSSQENMVEDCLYETVKEIKEVADKSQGGKSKSTSALKELQGAHAEGKADFAEYASVDRNKKCRHSTNAESILGTSSDLDEETPPPVPVKLLDENANLPEKGEHGAEEQAPEAPSGHSKRFSSLSYKSREEDPTLTEEEISAMYSSVNKPGQSAHKPGPESTCQCPQGPPQRSSSSCNDLYATVKDFEKTPNSISMLPPARRPGEEPEPDYEAIQTLNREDDKVPLGTNGHLVPKENDYESIGDLQQGRDVTRL
Protein: Macrophage immunometabolism regulator (B3DHS1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play a role in immune regulation through regulation of the macrophage function (By similarity). Involved in the recruitment of macrophages in response to injury. May also play a role in trafficking of proteins via its interaction with unc119 family cargo adapters (By similarity). May play a role in ciliary membrane localization.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96GV9}. Cell projection, cilium {ECO:0000250|UniProtKB:Q96GV9}.
Interaction partners:
Sequence:
MEMDASGASRAPISVLPAAEVKSTLKPEADKPRCSSTPCSPIKSTVSGYQILHMNSNYLVGFTTGEELLKLAQKWSSPDSSNTEALPSPIKKPVDLGLHRASRIYKAKSRYYQPYDIPAVNGRRRRRMPSSGDSCLKSIVSGEPSKALHGPLPLCLLKGKRVYSKSLDYLNLDKMSLREPVDTEVLQYQLQHLNLRGERVFTRNKT
Protein: COP9 signalosome subunit 7A (F5H4U8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNV
Protein: Mitochondrial import inner membrane translocase subunit TIM17-3 (Q9LYG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential component of the TIM17:23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Links the inner and outer membranes (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM23-1
- Mitochondrial import inner membrane translocase subunit TIM23-2
- Mitochondrial import inner membrane translocase subunit TIM23-3
- Mitochondrial import inner membrane translocase subunit TIM50
- Probable mitochondrial import inner membrane translocase subunit TIM21
- Mitochondrial import inner membrane translocase subunit TIM44-1
- Mitochondrial import inner membrane translocase subunit TIM44-2
- Mitochondrial import inner membrane translocase subunit TIM22-1
- Mitochondrial import inner membrane translocase subunit TIM22-4
- Mitochondrial import inner membrane translocase subunit PAM16 like 2
Sequence:
MDTKKKSKEHGLYRIVNAIGYAFGAGAVGGSVYHFVRGAYNSPIGARYVGGTQAASMNAPRLGGTFAVFGGLLSTFDYALVRIRKKEDPWNSIVAGAATGGVLSIRKGVVAASTSAVMFGFFLAVLNPPFGSK
Protein: FERM domain-containing protein (A0A8C0RSL8)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}.
Interaction partners:
Sequence:
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPIPAPLPPDISSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGTSSKHNTIKKVPSLLSRVIRLLFFMHT
Protein: Leucine-rich repeat protein (LRRP), putative (Q9N946)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKVRITDHNTFWHAPQLLPYNTSPPRLIHRLVLLLKKKKHFLNTQHLKESETGTTMSGNQGRKRQRSSSPEQSEALKEPSTTEQNKLTTITITEETRDASNDETVVSLLNEHKKLIKQTTRLESSVKALRCFMSNLTAMSGERQGGVCDDTECIHRVTLYNAADNAFSDEGLYEGALSSLCGRIQAKKLTIALSKDENFDLQGVSKLKQLEELRIEYPHGKLVNMISLNNLDMLKRLRLRSNNIDNNDARHLFSVGTLEELAITDTMQLTNIREISRLTNLKCLELNSTNIDDSCVEEISACVKLSKLSVSECNNVTDATPISQLAALEELNLSNCHITKGIGTLGMLLRLRILDLSGVPVEDNCLKDLCDCGSLERLNISYCIQLTDINPLSNATAIEELNLNGCRRITRGIGVVWALPRLRILHMKDVHLSEPSLDSVGTGGLLVKVSLDNCAGFGDMTLLSSIVTLEELNIQKCADIISGVGCLGTLPYLRVLNVKEVHISSLDFIGIGASKSLLQLTLESFTGLSNVEALANILTLEKLSLHGCTGIDAGIGCLGNLPQLKMLDLSGTNTDNESLRSLCLSQTVVSLNLSHCWKMTNVSHISSLEALNELNLSNCIRINAGWEAIEKLQQLHVAILSNTHITDRDISHFSKCKNLVTLDLSFCNKLLDVTTLSNITTLEELNLDSCSNIRKGLSVLGELPRLCVLNIKGVQLEDSVIGSLGNGNSFVRLSLENCKGFGGVTPLSNLVTLEELNLHYCDKVTSGMGTLGRLLQLRVLDLGRTQVDDNSLENICTCSSPLVSLNLSHCKKITSISAIASLTALEELNIDNCCNVTSGWNVFGTLHQLRVATLSNTRINDENIQHVSECKSLNTLNLAFCKDITDVTALSTITMLEELNLDCCHNIRKGIETLGKLPKVRILSMKECYMGDSDAQQCSILGNSKSLVKLNLERSMGFISVKALSNIATLEELVLDSVCGIYDVLSFSCLPRLRVLNLKYTDINDDVTKNISESKSLQSLNLSHCKWVTDISVLSSLSTLEELNVNFCNGIRKGWESLGKLPLLRVAILSDTNITAKDIACLSSCKKLVKLQFFRCEKLSDVTVVYEIQSLEELIVRKYSDGLKGLNALGTLSRLRFLHLRNARGSDISVESIGTSKSLVRLNIETREELTDATPLSNITSLEELSLRDCGDTLEGAWTLGKLPRLRSLDLGLSDISDNTLDEICLSRFITSLNLRYNFKLTDISSISNLTALEELNLSGCHRITSGWEALSELPRLRVLNLESTSVTTRDGGYYISRCKSLVTLNLESCDMTDASCLANIKTLEELHIGECDELTQGFSALFTLPRLRILNLMDSLITDEDLREIQPPHTIEELNLSYCKNLNDITPLGRIKSIKKLHLSQSHDVRRLREGFRSLLELPCLSWVDLRNVYGWFDVYVELRKKRVHIR
Protein: VWFA domain-containing protein (G4SNP7)
Organism: Caenorhabditis elegans
Interaction partners:
- UNC-45
Sequence:
MRRRRSPTIPILILGLVLPVLVSSQTYDAVPIGRPFLRPPPSPRQEEAPAPTLARGYQPPPRPSNFQPPRSYPSFRQPSLNLDNRQFPGNHQRAGQNFNWQMQQLQQQDPQRFGFRQQQRTIPQTPPSFQPPHNHFRAGAPGQIPHQGRQVAHFQRPHIQIPTSSILQRQTEVSPADIRNGPQQLDPVNNIIIHLYLNAKDRMPSHTEIKTPVRGLFGIGTSHGGPGTHSDPIVITKDFDRDTLEFVDEGQVQKPGASNIIEVKATVSTPNRQLENTVNNAVNKELNRAIPKVMDRMRGSTMTMDNGMRKELEEALVDELAKNLGETIDNTDITEEDLEKLIEEGFDEVRKIDQETTTTTTTKAPPTTRTPPTTRTPPTTSQPAEFNIDDDDYESSEDISESHTTPPTQTPPTQTPPTTTTTRRVTVVVTSPTTTTPRRTITTRIWTTTTTQAPPTEAPPTEAPPTTQTTPTSWTRPTDGRVHVMPGIRVTETPPTIQTPPPTTQTPPTTQTSSTTQTPRTKQTWAPWTPPTTTTRQTPPTTQAPPITPPPYRPPTSVVTYGPESEEIQHAEHAENGQISAIPTRKPTLIEVSPSTHHHHGIVNLESNEEDYESTVTSKPVIMFTTESTVVHNLPTKPSSAPTLHPSTFSPPLVTSSENPFTFTLDTTPTSTVTPMTSPPSTVTETTPTSTVTPRRYTVDEIVKIEVAPHTIYTEEPFFSTSSIEWNPITSAEDYSSPTVPTTTVTPEVVREDEDYDYTNEFAIPNEPIVTTTTTAIASTTNSETSKPRHQSSSSEEIQPNFVIPSGACPTPNRPEIDRNRTDILFLLDSSDNFTEQKFQRAIKLIGETVGQFSNFGADGVQVSLVQYNDEPYLEFSLRKHNCKKHLLADIADTEFMTGGSQLNKALEKVSQFAFTKKRGDRPDAENILIIVTDGQSDARIQEPTRLVKDHNVTVLVISTLEADKNFIINLSAENLYDSDNFGKDLAWKLAKRISDSSPKYSVKNPENSKILTPVLPDLNENLAESPEVLVTTRPENAETAENSGIIDLECVGDGFKVQVNPPAGFRGVAVVKGYQDDARCKATASSSLPLNLFISNNECGVTQVKSSDPNGLNSSLVLHLLHDDELNTAEDRAYLLQCFIGAQNQDAVVSTNLNVVRSELAIAETISLSTLPPTCTYSIRKEGPEGPIVSRAVVGQTVWHRWECDGTNDTNQAYGIQVHSCYASDDVERKFAFVDPRGCSSDLALLTDLTYADDSLTAWAASHVFNVHDAESLKFVCKLSLCTRDGDGCEGVTPPACGNTNKTGLLLTKRLAKGINSVDEALTSALSTNVKLTSGSSDGLEDLLKSATSSYLFWVVALVAVAAIVAISILSRNMAENSDTATTCSDPTTMSESQDFGGSIRSISSPPPPNRQLADFMRSFDRNRYV
Protein: Abl interactor 2 (E7EP65)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSADKQRALEETKAYTTQSLASVAYLINTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANLERPVRYIRKPIDYTILDDIGHGVKWLLRFKVSTQNMKMGGLPRTTPPTQKPPSPPMSGKGTLGRHSPYRTLEPVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHPVQFYSMNRPASRHTPPTIGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPVSDTPPPPPPVEEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDD
Protein: Eb1, isoform A (Eb1, isoform B) (Eb1, isoform D) (Eb1, isoform G) (RE41364p) (Q7JZD3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAVNVYSTNVTSENLSRHDMLAWVNDCLQSQFSKIEELCTGAAYCQFMDMLFPNSVPVKRVKFRTNLEHEYIQNFKILQAGFKKMSVDKIIPIDKLVKGRFQDNFEFLQWFKKFFDANYDGRDYDASAVREGAPMGFGSGAVKSLPGTAASGVSSSYRRGPSATTRPAMTSAVKPTVSKVLPRTNNAAPASRINACANSTGTVKKNDVSNSVNNQQIEEMSNQVMDMRINLEGLEKERDFYFSKLRDIEILCQEADDAEAHPIIQKILDILYATEDGFAPPDDAPPEDEEY
Protein: Cytosol aminopeptidase (EC 3.4.13.23) (Cysteinylglycine-S-conjugate dipeptidase) (Leucine aminopeptidase 3) (Proline aminopeptidase) (Prolyl aminopeptidase) (A1Z9G3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RE13973p
- Gamma-glutamyl transpeptidase, isoform A
- Uncharacterized protein, isoform C
- glutathione-specific gamma-glutamylcyclotransferase
- GCS light chain
- Pyrroline-5-carboxylate reductase
- glutathione-specific gamma-glutamylcyclotransferase
- Pyrroline-5-carboxylate reductase
- Glutamate--cysteine ligase
- Proline dehydrogenase 1, mitochondrial
Sequence:
MASTRMISAFTRNPRLYQQVTAPWKSYNLFGTPLFNHRLQPADSQIWRGLADKCDNKTVIKGVVVGVYSKEGDGKEVKMTSSGEKFDDRTQGKVSELLRETGIKGELGKGKVFMNVDAEFRAVAVVGLGQEGAGFNDLENIDEGMENARVAAGVGARALQLQGCTEVFVDSMEYPEQAAEGSALAIWRYNSNKRKQDRTQVPKLDLYDSPDVDAWTRGLFKAESQNLARRLSDSPANQMTPTIFAQSAVDALCPCGVSVEVRSMDWIEMNHLNSFLMIAKGSCEPPVVLEVSYCGTAPEDRPILLLGKGLTYNSGGLCLRPKDCLHMYRGCMAGAAVCVAAVRAAAALSLPVNITAVLPLCENMPSGMAVKPGDVVTLLNGKTMGIVDVSKAGTVVLADPLLFAQTTYKPRLVVDLATVGYGVCAGLGESAAGLFTNSNFIAKQFEKAGGLTGDRLWRLPLWRYFKQLVTPNLTFDISNRGIGPASSCIAAAVLHELVPCADWAHIDIRNVGMLTRHNPLPYLLKDRMTGRPTRTIVQFLYQMACPESK
Protein: 30S ribosomal protein S1 (C3TGB2)
Organism: Escherichia coli
Interaction partners:
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein bL19
- 30S ribosomal protein S5
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS3
Sequence:
MTESFAQLFEESLKEIETRPGSIVRGVVVAIDKDVVLVDAGLKSESAIPAEQFKNAQGELEIQVGDEVDVALDAVEDGFGETLLSREKAKRHEAWITLEKAYEDAETVTGVINGKVKGGFTVELNGIRAFLPGSLVDVRPVRDTLHLEGKELEFKVIKLDQKRNNVVVSRRAVIESENSAERDQLLENLQEGMEVKGIVKNLTDYGAFVDLGGVDGLLHITDMAWKRVKHPSEIVNVGDEITVKVLKFDRERTRVSLGLKQLGEDPWVAIAKRYPEGTKLTGRVTNLTDYGCFVEIEEGVEGLVHVSEMDWTNKNIHPSKVVNVGDVVEVMVLDIDEERRRISLGLKQCKANPWQQFAETHNKGDRVEGKIKSITDFGIFIGLDGGIDGLVHLSDISWNVAGEEAVREYKKGDEIAAVVLQVDAERERISLGVKQLAEDPFNNWVALNKKGAIVTGKVTAVDAKGATVELADGVEGYLRASEASRDRVEDATLVLSVGDEVEAKFTGVDRKNRAISLSVRAKDEADEKDAIATVNKQEDANFSNNAMAEAFKAAKGE
Protein: Siderophore iron transporter mirB (Major facilitator iron-regulated transporter B) (Triacetylfusarinine C permease) (Q870L2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- GATA-type transcription factor sreA
Sequence:
MTIGSKFSLLAGTRKTDGPTEISASSPPDVETPSAEKTATASAGNKEVGINDNSSDEALPSQHVQTGVQKIQAVTLVWSKWSLVAVFCLLWLVTLANGFRQSILYSLTPYATSSFQSHSLLTVINIVSSAMVSALYIPVAKVVDVWGRAEGWLVMVGLSTLGLIMMAASKNLETYCAADVFYSVGFAGMNYILCVLAADITNLRNRGIAFAFTSSPYMITAFAGSKAAEKFLVNVNWRWGFGAFAIIFPFVASPVYFVLKVGLNRAEKQGIIQPRLRSGRTLSQNFKYYFFAFDIPGVILLAGGLTVFLLPFTLATRAPNGWKSDYIIAMIVTGFVVMVLFVLYQAYWAPQPFLKYEFLTNRTVLGACLIDATYQMSYYCWNSYFNSFLQVVCNLPVAEAGYVGSTFQVVSGVLLFMVGFAIRKTGYFRWLLFIGVPLYIFAQGLMIHFRQPNQYIGYIVMCEIFISIGGSIFVLLQQLAVLVAVDHQYVAAALAVLFISGGIGGAVGNAISGAIWTNTFLPALMRNLPESAKANAVAIYGDLRVQLSYPVNSPERIAIQESYGYAQARMLAAGTGLMALMFIWMFMVKNYNVKNMSQTKGMVF
Protein: Sirtuin 3 (A0A8I5XWT5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRSPDLAPQPISQSLTDGEAANTRHKPTLRHIGLTFRGLAWEPITGGRRPISLSVGASGGFGCGGHSEKKLSLQDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFTLAKELYPGHYRPNVAHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGSFVSATCTVCRRSFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHVADFALADLLLILGTSLEVEPFASLSESVQKSVPRLLINRDLVGSFALSPRRKDVVQLGDVVQGVERLVDLLGWTQELQDLIQRENGKLDGQDG
Protein: Xylanase inhibitor protein 1 (XIP-1) (XIP-I) (Class III chitinase homolog) (Q8L5C6)
Organism: Triticum aestivum (Wheat)
Function: Fungal xylanase inhibitor. Possesses competitive inhibiting activity against fungal endo-1,4-beta-D-xylanases belonging to glycoside hydrolase family 10 (GH10) and family 11 (GH11). Possesses also inhibitory activity towards barley alpha-amylases. Binding to xylanases or amylases is necessary for inhibition activity. May function in plant defense against secreted fungal pathogen xylanases. Is similar to class III chitinases, but does not exhibit chitinase activity.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Beta-hexosaminidase
- Beta-hexosaminidase
- Beta-hexosaminidase
- Beta-hexosaminidase
- Beta-hexosaminidase
- Beta-hexosaminidase
- Beta-hexosaminidase
- Beta-hexosaminidase
- Beta-hexosaminidase
- Beta-hexosaminidase
Sequence:
MAPLAARRPACLLALLSVAAALFLTPTALAAGGKTGQVTVFWGRNKAEGSLREACDSGMYTMVTMSFLDVFGANGKYHLDLSGHDLSSVGADIKHCQSKGVPVSLSIGGYGTGYSLPSNRSALDLFDHLWNSYFGGSKPSVPRPFGDAWLDGVDLFLEHGTPADRYDVLALELAKHNIRGGPGKPLHLTATVRCGYPPAAHVGRALATGIFERVHVRTYESDKWCNQNLGWEGSWDKWTAAYPATRFYVGLTADDKSHQWVHPKNVYYGVAPVAQKKDNYGGIMLWDRYFDKQTNYSSLIKYYA
Protein: Cadherin-1 (Epithelial cadherin) (E-cadherin) (Liver cell adhesion molecule) (L-CAM) (P08641)
Organism: Gallus gallus (Chicken)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha-E/beta-7.
Subcellular location: Cell junction, adherens junction {ECO:0000250|UniProtKB:P09803}. Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Endosome {ECO:0000250|UniProtKB:P12830}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P12830}. Cytoplasm {ECO:0000250|UniProtKB:P09803}. Cell junction, desmosome {ECO:0000250|UniProtKB:P12830}.
Interaction partners:
- Catenin beta 1
- Plakoglobin
- Actin, cytoplasmic 1
- Caspase-3
- Cadherin-2
- Zinc finger E-box-binding homeobox 1
- Disintegrin and metalloproteinase domain-containing protein 10
- Cadherin-5
- Uncharacterized protein.
- Epidermal growth factor receptor
Sequence:
MGRRWGSPALQRFPVLVLLLLLQVCGRRCDEAAPCQPGFAAETFSFSVPQDSVAAGRELGRVSFAACSGRPWAVYVPTDTRFKVNGDGVVSTKRPLTLYGRKISFTIYAQDAMGKRHSARVTVGRHRHRRHHHNHHLQDTTPAVLTFPKHDPGFLRRQKRDWVIPPISCLENHRGPYPMRLVQIKSNKDKESKVYYSITGQGADSPPVGIFIIERETGWLEVTEQLDREKIDRYTLLSHAVSASGQPVEDPMEIIITVMDQNDNKPVFIKEVFVGYIEENAKPGTSVMTVNATDADDAVNTDNGIVSYSIVSQQPPRPHPQMFTIDPAKGIISVLGTGLDRETTPNYTLIVQATDQEGKGLSNTATAIIEVTDANDNIPIFNPTMYEGVVEENKPGTEVARLTVTDQDAPGSPAWQAVYHIKSGNLDGAFSIITDPSTNNGILKTAKGLDYETKSRYDLVVTVENKVPLSVPITLSTASVLVTVLDVNEPPVFVPPIKRVGVPEDLPVGQQVTSYTAQDPDRDMRQKITYRMGSDPAGWLYIHPENGIVTATQPLDRESVHAINSTYKAIILAVDNGIPDTTGTGTLLLLLQDVNDNGPTPEPRSFEICSRQPEKQILSIVDKDLPPHTYPFKAALEHGSSNNWTVEIRGQDELAMGLKKELEPGEYNIFVKLTDSQGKAQVTQVKAQVCECEGTAKNCERRSYIVGGLGVPAILGILGGILALLILLLLLLLFARRRKVEKEPLLPPEDDMRDNVYNYDEEGGGEEDQDYDLSQLHRGLDARPEVIRNDVAPPLMAAPQYRPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGGGSEATSLSSLNSSASDQDQDYDYLNEWGNRFKKLAELYGGGEDDE
Protein: Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (D3DMF6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVYIIPFFSHNDPPDMIITKEKSMACLQDEFGHLGIAATDLPFKSSDLDSPPRLQHHNNYAEITDSSAENTCQQRWPPHVGGAGAAFGHPDKPIGWMYGLLGCMKPVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAERERKLPGSGYKPNRRFGNTIRKMQHYRRRLNPAPAAIQQQSTTPDPETTPESPVKCMLYAQLDSNCQPKSYLANIIPSSGLGAPMPNKNKKVFRHRRNASGSFGAPPKYSPTRDRRYQSEPENRKVQLVERQTQTDAMDVSETDISPSAEAPRSQPIDVPVPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVNPACPSNGNSLSTSELTYQDACSSPDQLIDDVMNSNERLDMTECCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADNGNGGASPLELRESGNSPCLSRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQDSWSDEEGETTDYKYALRRRSIGRQPIARGMRPRRSYKAPLSQKIAIHKRNVVIVSDEEENTSEYSHSPSSQHSTLESNTDIADMKKTQATSTSSNSYSEPEDDSSDSSDEEQGNRPTEAKAEGPALPMGAVRSSDIISIPTFEADGAVNMV
Protein: PrnA protein (Q5BCK1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- NADH-quinone oxidoreductase subunit D domain-containing protein
Sequence:
MDEAPSTPAVGNQKRPRVSEENRKRAVRACDGCRRVKEKCEGGVPCRRCTRYRRQCVFTHPDQADRLSRSSSISLLERTAARSRHDMLESERIRCMERILQHYVPNISFDIQSLRKTAEELKSKHRGSDSDGGPSVVFDNEDMEDLAIEDEDFTIKALPDNTTQYSGEFSYLNFSMKIKKKIDEWMKAESPEASTEAEPFEERWRATQLQSGAVVAASVTSLPPRFVADFLVQMFFKYAQTNNFYVEEDWLKDKLNTCYVNPGSLGCNDAGAVCSILMVLAIGTQFAHMESATPVNHLTSEADHFSEDEVGLTFYQFASKLLPDIIASASIRSVQACLLIGTYLLPLDTSGLCYTYFGLALKMAIQNGMHRKYSGEGLPPHVIEIRNRVFWTAYTIEKRVSILHGRPVSLSDTDVDAAMPVDFPGLMPHGQVSNHTNMVTLIKLTLKLGEVSNEICALRKCRKNQQQDCLERLLTLRKHLVDWWNTLPEETDCRDLNPNGPLFRANVHLKLDYCLTRIFLGRPFLFSSMKGFSSATFQISPVKAPMSSGVSKNRSTLVTDCVEAALEIIDLCRLLRDETGLARASFTEFSSCRAALLVILAQSLTKRTERLREALQKGMGLIKIMSMGVGSARSAVSVIEALERAISRLEEYSASQGAGQSGSHESAYDRFKNWEMLWKTGPVSPDAHTLTNANTHTNIFQSQGQGQDGYQSGGSGVQPHLASLTPTSSLMNSQSQLHNENAAVPHHDITSPSDFLTPHAFSQMPHIGLDHFVSNLPQELGEFTAIPCFETEGQTGPSSGAGPGLPGELDMKEGWMTF
Protein: Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1) (Q9H3M7)
Organism: Homo sapiens (Human)
Function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8BG60}.
Interaction partners:
- NACHT, LRR and PYD domains-containing protein 3
- Thioredoxin, mitochondrial
- Thioredoxin
- DNA damage-inducible transcript 4 protein
- E3 ubiquitin-protein ligase Itchy homolog
- Tyrosine-protein phosphatase non-receptor type 11
- Guanine nucleotide exchange factor VAV2
- Caspase-1
- Heme oxygenase 1
- Cellular tumor antigen p53
Sequence:
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
Protein: Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein) (Q6RW13)
Organism: Homo sapiens (Human)
Function: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein {ECO:0000269|PubMed:12960423}. Golgi apparatus membrane {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein {ECO:0000269|PubMed:12960423}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12960423}; Multi-pass membrane protein {ECO:0000269|PubMed:12960423}. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Interaction partners:
- Type-1 angiotensin II receptor
- Angiotensinogen
- Guided entry of tail-anchored proteins factor CAMLG
- Cytoplasmic phosphatidylinositol transfer protein 1
- H
- Muscarinic acetylcholine receptor M3
Sequence:
MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY