wanglab/gogpt-training-data huggingface dataset:
Protein: Lysine-specific demethylase JMJ706 (EC 1.14.11.66) (Jumonji domain-containing protein 706) (Lysine-specific histone demethylase JMJ706) (Protein JUMONJI 706) ([histone H3]-trimethyl-L-lysine(9) demethylase JMJ706) (Q336N8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me3 and H3K9me2. No activity on H3K4me3, H3K9me1, H3K27me2 and H3K36me3/2. Involved in the control of floral organ development by demethylating H3K9me3 and H3K9me2 in the promoter regions of DH1 and MADS47. The 'Lys-9' demethylation of these two genes is required for induction of their expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:18765808}. Note=Localizes mainly in heterochromatin foci.
Interaction partners:
- ATP synthase subunit b, chloroplastic
- ATP synthase subunit alpha, chloroplastic
- ATP synthase subunit alpha
- ATP synthase subunit a
- F-ATPase protein 6
- ATP synthase subunit a, chloroplastic
- ATP synthase subunit d
- Os06g0646500 protein
- Os06g0714700 protein
- ATP synthase F1, delta subunit family protein, expressed
Sequence:
MQQVEGRNCLPAEVRIGLETLKRRRLERMRLTAQNNAGDGPPVPARSGGDALRTPANCGVRLHANNGTALPSRTTQNKDPFAKRRVDKFDMSSLEWIDKIEECPVYYPTKEEFEDPIGYIQKIAPVASKYGICKIVSPVSASVPAGVVLMKEQPGFKFMTRVQPLRLAKWAEDDTVTFFMSERKYTFRDYEKMANKVFAKKYSSASCLPAKYVEEEFWREIAFGKMDFVEYACDVDGSAFSSSPHDQLGKSNWNLKNFSRLSNSVLRLLQTPIPGVTDPMLYIGMLFSMFAWHVEDHYLYSINYHHCGAFKTWYGIPGDAAPGFEKVASQFVYNKDILVGEGEDAAFDVLLGKTTMFPPNVLLDHNVPVYKAVQKPGEFVITFPRSYHAGFSHGFNCGEAVNFAISDWFPLGSVASRRYALLNRTPLLAHEELLCRSAVLLSHKLLNSDPKSLNKSEHPHSQRCLKSCFVQLMRFQRNTRGLLAKMGSQIHYKPKTYPNLSCSMCRRDCYITHVLCGCNFDPVCLHHEQELRSCPCKSNQVVYVREDIQELEALSRKFEKDICLDKEISGFDSYKQAEKNEPFFEITRNLRNTEVNLIEDAFSGATAADAAKSSPATSTLTSFAQHDVPVLAEAIVCANQADQLYSTTEQTISSPLVKGTDAVGANSSSMADANNGTGSCNASAVEYSGNSDSESEIFRVKRRSGVSVKPASDAKTSNLSDQQVLRRLKKVRPEIQQHNKRPEDYGHCSVPSGRMSMKNLNSSSSCGEEHWRMKRRQLETQQDESSYSAKQKSYSYPSTSYSFRGEFVEMSRDAAAEVRPKRLKIRLPSSSTNRVVEQGSSGQRFTRDDKSLGCWPAI
Protein: Aflatoxin cluster transcriptional coactivator aflS (Aflatoxin biosynthesis protein S) (O42716)
Organism: Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
Function: Transcription coactivator involved in regulation of the aflatoxin biosynthesis gene cluster with aflR. The ratio of the expression data between aflS:aflR plays a crucial role in the regulation of aflatoxins production. A high ratio, produced at a range between 17 and 30 degrees Celsius, corresponds with the production profile of aflatoxin G1 biosynthesis. A low ratio, produced over 30 degrees Celsius, is related to aflatoxin B1 biosynthesis. AflJ may act in aflR transport to or from the nucleus, thus controlling the availability of aflR for transcriptional activation of aflatoxin biosynthesis cluster genes. AflJ may also assist in directing endosomes to the cytoplasmic membrane for aflatoxin export.
Subcellular location: Nucleus {ECO:0000269|PubMed:23342682}. Endosome {ECO:0000269|PubMed:23342682}.
Interaction partners:
- Aflatoxin biosynthesis regulatory protein
Sequence:
MTLTDLETCAEEIATAARTLARDGHSGGYSAGLPDHLRAVQRTLIANASQVLALASQPADLVRQLALYNQLLACLRWLGEFQVLACIPLDESVPFEDVADIAGVPECRLRRLVRPLFTIGFLCEPSPGHVAHSVLSKQFVTQPALLDAILFMSETLAPSASAMGTQTRRFGASEQAGDSAWNMAVGSDSPFAACLQQRPKVKRQLGAYLSYVSSAIDAGVEDTLTRMNWQNLGMATVVHVGAQSPSLVVALAPQFPSLRFLVQTEAKAESGGHQPCLDNHGIPALKLASIPLHLRARITWGTRLSTATQPVLDAAVYLISIPFPSPQSPAMEITMRVAQALKAHVEVLRNNSDARLILTLPMSSATRSMDAAARAAVSLSDLSLLQLTNGGSLNMGEIRDLLRSRSDGLVVMREVRSPTNAVIAFEIQYRVDNDDNRY
Protein: 14-3-3 family protein (14-3-3 protein (Grf15), putative) (Q9SHV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable protein phosphatase 2C 22
- ATP synthase subunit epsilon, mitochondrial
- Dual specificity phosphatase Cdc25
- Tobamovirus multiplication protein 2B
Sequence:
MCCYFATRIVYGLQPEALMMLDALGDELYKDSTLIMKILRDNLTFWTSDMTDEAGDEIKEAEPKVLCKCHSCFTVLSEPKHS
Protein: Beta-barrel assembly-enhancing protease (EC 3.4.-.-) (P66948)
Organism: Escherichia coli (strain K12)
Function: Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state. Promotes disulfide rearrangement of LptD during its biogenesis, and proteolytic degradation of LptD and BamA when their proper assembly is compromised. May facilitate membrane attachment of LoiP under unfavorable conditions.
Subcellular location: Periplasm {ECO:0000255|HAMAP-Rule:MF_00997, ECO:0000269|PubMed:22491786, ECO:0000269|PubMed:24003122}. Note=A significant amount of BepA is membrane-associated. This localization could result from interaction with the BAM complex.
Interaction partners:
- Uncharacterized protein YfgD
- Metalloprotease YcaL
- LPS-assembly protein LptD
- Chaperone SurA
- Periplasmic serine endoprotease DegP
Sequence:
MFRQLKKNLVATLIAAMTIGQVAPAFADSADTLPDMGTSAGSTLSIGQEMQMGDYYVRQLRGSAPLINDPLLTQYINSLGMRLVSHANSVKTPFHFFLINNDEINAFAFFGGNVVLHSALFRYSDNESQLASVMAHEISHVTQRHLARAMEDQQRSAPLTWVGALGSILLAMASPQAGMAALTGTLAGTRQGMISFTQQNEQEADRIGIQVLQRSGFDPQAMPTFLEKLLDQARYSSRPPEILLTHPLPESRLADARNRANQMRPMVVQSSEDFYLAKARTLGMYNSGRNQLTSDLLDEWAKGNVRQQRAAQYGRALQAMEANKYDEARKTLQPLLAAEPGNAWYLDLATDIDLGQNKANEAINRLKNARDLRTNPVLQLNLANAYLQGGQPQEAANILNRYTFNNKDDSNGWDLLAQAEAALNNRDQELAARAEGYALAGRLDQAISLLSSASSQVKLGSLQQARYDARIDQLRQLQERFKPYTKM
Protein: Peroxisomal membrane protein pex13 (Peroxin-13) (O14136)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:P80667}; Single-pass membrane protein {ECO:0000250|UniProtKB:P80667}.
Interaction partners:
- Peroxisomal membrane protein pex14
- Uncharacterized protein C17C9.14
- Peroxisomal targeting signal receptor
- Peroxisomal targeting signal 2 receptor
- Peroxisomal biogenesis factor 11
- Peroxisome assembly protein 12
- Peroxisomal ATPase pex6
- Peroxisome biogenesis factor 10
- Uncharacterized protein C29A4.14c
- Peroxisomal ATPase pex1
Sequence:
METNQNEKGPSLPSYPAGGIMSVSNSNADTNQGVTQHPLANRIVNPNYYNMGFNPYSGFNSFIPSFNPFVPLETNLPGNGPISSLQVIESIVGAVGSIAQVLESTLMAAHMSYNTFVSVSENLNKLKSSIGAIFGIVSLLSRLKRLVLKFFKHSKIDEMNSQEYDVFEKEEGNHKNSIYSIVSSLAIILGLVGLPYAIIRLFKNIYEKEKQIQQAKIRKKIDSLEFCKADYEFMSRDPGVEMSLKKGDIIAILSKTDTQGNPCEWWQGRKRSGETGWFPSNYCSIISR
Protein: Interferon inducible GTPase 1C (Interferon-gamma-inducible GTPase Ifgga2 protein) (Predicted gene, EG240327) (Q3UED7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGQLFSSRRSEDQDLSSSFIEYLKECEKGINIIPHEIITSIEINMKKGNIQEVNSTVRDMLREIDNTPLNVALTGETGSGKSSFINTLRGIGHEEGGAAHTGVTDKTKERHPYEHPKMPNVVFWDLPGTGSEDFQPKTYLEKMKFYEYDFFIIISATRFKKNDIDLAKAIGIMKKEFYFVRTQVDSDLRNEEDFKPQTFDREKVLQDIRLNCVNTFRENGIAEPPIFLISNKNVCHYDFPVLMDKLISDLPVFKRQNFMFSLPNITDSVIEKKRNFLRWKTWLEGFADGLLSFFLESDLETLEKSMKFYRTVFGVDDASLQRLARAWEIDQVDQVRAMIKSPAVFTPTDEETIQERLSRYNQEFCLANGYLLPKNHCREILYLKLYFLDMVTEDAKTLLKEICLRN
Protein: Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) (Q9BYV8)
Organism: Homo sapiens (Human)
Function: Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes mainly to the cilium basal body and in primary cilia.
Interaction partners:
- Mesoderm-specific transcript homolog protein
- Tubulin polyglutamylase TTLL6
- Serine/threonine-protein kinase PLK1
- Transmembrane protein 237
- Multivesicular body subunit 12A
Sequence:
MSLRRHIGNPEYLMKRIPQNPRYQHIKSRLDTGNSMTKYTEKLEEIKKNYRYKKDELFKRLKVTTFAQLIIQVASLSDQTLEVTAEEIQRLEDNDSAASDPDAETTARTNGKGNPGEQSPSPEQFINNAGAGDSSRSTLQSVISGVGELDLDKGPVKKAEPHTKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKNAHGKIIILYDDDERLASQAATTMCERGFENLFMLSGGLKVLAQKFPEGLITGSLPASCQQALPPGSARKRSSPKGPPLPAENKWRFTPEDLKKIEYYLEEEQGPADHPSRLNQANSSGRESKVPGARSAQNLPGGGPASHSNPRSLSSGHLQGKPWK
Protein: Prophage integrase IntD (Prophage DLP12 integrase) (Prophage QSR' integrase) (P24218)
Organism: Escherichia coli (strain K12)
Function: Integrase from the cryptic lambdoid prophage DLP12. Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
Interaction partners:
- Prophage integrase IntA
- Prophage integrase IntF
- Prophage integrase IntE
- Prophage integrase IntS
Sequence:
MSLFRRNEIWYASYSLPGGKRIKESLGTKDKRQAQELHDKRKAELWRVEKLGDLPDVTFEEACLRWLEEKADKKSLDSDKSRIEFWLEHFEGIRLKDISEAKIYSAVSRMHNRKTKEIWKQKVQAAIRKGKELPVYEPKPVSTQTKAKHLAMIKAILRAAERDWKWLEKAPVIKIPAVRNKRVRWLEKEEAKRLIDECPEPLKSVVKFALATGLRKSNIINLEWQQIDMQRRVAWVNPEESKSNRAIGVALNDTACKVLRDQIGKHHKWVFVHTKAAKRADGTSTPAVRKMRIDSKTSWLSACRRAGIEDFRFHDLRHTWASWLIQSGVPLSVLQEMGGWESIEMVRRYAHLAPNHLTEHARKIDDIFGDNVPNMSHSEIMEDIKKA
Protein: Aldehyde oxidase 3 (EC 1.2.3.1) (Aldehyde oxidase homolog 1) (Azaheterocycle hydroxylase 3) (EC 1.17.3.-) (G3X982)
Organism: Mus musculus (Mouse)
Function: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11562361, ECO:0000269|PubMed:15383531}.
Interaction partners:
- Nicotinamide N-methyltransferase
- Aldehyde dehydrogenase, mitochondrial
- Amine oxidase [flavin-containing] B
- Aldehyde dehydrogenase 1A1
- Amine oxidase [flavin-containing] A
- Cytochrome P450 1A2
- Aldehyde dehydrogenase, cytosolic 1
- All-trans-retinol dehydrogenase [NAD
- Alcohol dehydrogenase 1
- Retinaldehyde dehydrogenase 3
Sequence:
MSPSKESDELIFFVNGKKVTERNADPEVNLLFYLRKVIRLTGTKYGCGGGDCGACTVMISRYDPISKRISHFSATACLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLLRNHPEPSTEQIMETLGGNLCRCTGYRPIVESAKSFCPSSTCCQMNGEGKCCLDEEKNEPERKNSVCTKLYEKKEFQPLDPTQELIFPPELMRMAEESQNTVLTFRGERTTWIAPGTLNDLLELKMKHPSAPLVIGNTYLGLHMKFTDVSYPIIISPARILELFVVTNTKQGLTLGAGLSLTQVKNVLSDVVSRLPKEKTQIYCALLKQLKTLAGQQIRNVASLGGHIISRLPTSDLNPILGIGNCILNVASTEGIQQIPLNDHFLAGVPDAILKPEQVLISVFVPRSSKWEFVSAFRQAPRQQNAFATVNAGMKVVFKEDTNTITDLGILYGGIGATVISADKSCRQLIGRCWDEEMLDDAGKMICEEVSLLMAAPGGMEEYRKTLAISFLFMFYLDVLKQLKTRDPHKYPDISQKLLHILEDFPLTMPYGMQSFQDVDFQQPLQDPIGRPIMHQSGIKHATGEAVFCDDMSVLPGELFLAVVTSSKSHAKIISLDASEALASLGVVDVVTARDVPGDNGREEESLYAQDEVICVGQIVCAVAADSYAHAQQAAKKVKIVYQDIEPMIVTVQDALQYESFIGPERKLEQGNVEEAFQCADQILEGEVHLGGQEHFYMETQSVRVVPKGEDKEMDIYVSSQDAAFTQEMVARTLGIPKNRINCHVKRVGGAFGGKASKPGLLASVAAVAAQKTGRPIRFILERRDDMLITGGRHPLLGKYKIGFMNNGKIKAADIQLYINGGCTPDDSELVIEYALLKLENAYKIPNLRVRGRVCKTNLPSNTAFRGFGFPQGAFVTETCMSAVAAKCRLPPEKVRELNMYRTIDRTIHNQEFDPTNLLQCWEACVENSSYYNRKKAVDEFNQQRFWKKRGIAIIPMKFSVGFPKTFYYQAAALVQIYTDGSVLVAHGGVELGQGINTKMIQVASRELKIPMSYIHLDEMSTVTVPNTVTTGASTGADVNGRAVQNACQILMKRLEPIIKQNPSGTWEEWVKEAFVQSISLSATGYFRGYQADMDWEKGEGDIFPYFVFGAACSEVEIDCLTGAHKNIRTDIVMDGSFSINPAVDIGQIEGAFVQGLGLYTLEELKYSPEGVLYTRGPHQYKIASVTDIPEEFHVSLLTPTPNPKAIYSSKGLGEAGTFLGCSVFFAIAAAVAAAREERGLSPIWAINSPATAEVIRMACEDQFTNLVPQTDSKCCKPWSIPVA
Protein: Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) (P13807)
Organism: Homo sapiens (Human)
Function: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Interaction partners:
- Glycogenin-2
- Glycogenin-1
- 1,4-alpha-glucan-branching enzyme
- Protein phosphatase 1 regulatory subunit 3C
- Transcription factor SOX-12
- Glycogen synthase kinase-3 beta
- Protein phosphatase 1 regulatory subunit 3B
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- UTP--glucose-1-phosphate uridylyltransferase
- 5'-AMP-activated protein kinase subunit beta-2
Sequence:
MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN
Protein: Helix-loop-helix protein 2 (HEN-2) (Nescient helix loop helix 2) (NSCL-2) (Q64221)
Organism: Mus musculus (Mouse)
Function: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis. Acts as a transcriptional activator of target genes, including Ndn, Pcsk1, Mc4r. Is also a transcriptional activator of KISS1 (By similarity). May act centrally to regulate function of both white and brown adipose tissue. Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei. Also, in concert with Nhlh1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Neuroendocrine convertase 1
Sequence:
MMLSPDQAADSDHPSSTHSDPESLGGADTKVLGSVSDLEPVEEADGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (B5LY74)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAGDALEVRDLTAEDSSPVNELSFSLQNLQCQDGLSPKCSTPRKLVLTPECMSSSLNTLSREKETPTVRRRRARSLSPESTSNTPRCPWRNNQDFPANKENERAIKRLRVRLSSRFSSSNATETAGRNRRQYRSDPEEDATPSRETEAVDPMAAVRFRQLMSQLQAPPTPVTQVAVADLTLIGDFSKQHLLPVESAGHQEHHCVSAQTVASLIRGQFGSAVEDFLIVDCRYPYEYQGGHIKGAVNLYTEHQVQQVLHQASAQVSVSPSWPCGRSASDSLPEDEESPSRKLIIFHCEFSSERGPHLCQYLRRLDRCVNVYPSLHYPELYLLLGGYKHFHASYPDLCDPCGYVSMRQREYREQLNSFLRRRQTRQRRRRPIRRHPRTKR
Protein: Serine/threonine-protein kinase D6PKL2 (EC 2.7.11.1) (D6 protein kinase-like 2) (Serine/threonine-protein kinase AtPK5) (Q39183)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein kinase that regulates the auxin transport activity of PIN auxin efflux facilitators by direct phosphorylation. D6PK-mediated PIN phosphorylation promotes auxin transport in the hypocotyl and this is a prerequisite for PHOT1-dependent hypocotyl bending.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with PIN1 to the basal (lower) membrane of root cells. {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase-like protein At5g23170
Sequence:
MASTRKPSGHGAEVEAQKRSSSNSSTKSAKAETFEPMQLQRSVTNPRAVGIPESKRLPESFRKRSSDPAVCKPDFSSLSTVLEHVDSLTIDEKKTSGFGSVKTSSASAKLSDGTSSLGKTSGSAKLSGRLDFMESGKSSICRGSTSSDVSDESSCSSFSSTVNKPHKANDLRWEAIQAVRVRDGLLGLSHFRLLKRLGCGDIGSVYLSELSGTKCYFAMKVMDKTSLASRKKLLRAQTEREILQSLDHPFLPTLYTHFETEKFSCLVMEFCPGGDLHTLRQRQPGKHFSEQAVKFYIAESLLALEYLHMLGIVYRDLKPENVLVREDGHIMLSDFDLSLRCLVSPTLVKSAAIESDPLRKNVYCVQPACIEPSCIQPSCTVPTTCFSPRLFSSKSKKDRKPKNDTANQVRPLPELVAEPTDARSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGRTPFKGSGNRQTLFNVVGQPLRFPETPVVSFAARDLIRGLLMKEPQQRLGFKRGATEVKQHPFFEGVNWALIRCATPPEIPKPVELEKGAVSVAEAPSSQKTAAGLVLNAQKGSDNYLEFDFF
Protein: Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (GCS) (Gamma-glutamylcysteine synthetase) (P32477)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine (gamma-GC), the first and rate-limiting step in the production of glutathione (GSH).
Interaction partners:
- Glutathione synthetase GSH2
- Glutathione reductase
- Glutathione hydrolase proenzyme
- Cystathionine gamma-lyase
- 5-oxoprolinase
- Cys-Gly metallodipeptidase DUG1
- Catalase T
- Cystathionine beta-lyase
- Branched-chain-amino-acid aminotransferase, cytosolic
- Homocysteine/cysteine synthase
Sequence:
MGLLALGTPLQWFESRTYNEHIRDEGIEQLLYIFQAAGKRDNDPLFWGDELEYMVVDFDDKERNSMLDVCHDKILTELNMEDSSLCEANDVSFHPEYGRYMLEATPASPYLNYVGSYVEVNMQKRRAIAEYKLSEYARQDSKNNLHVGSRSVPLTLTVFPRMGCPDFINIKDPWNHKNAASRSLFLPDEVINRHVRFPNLTASIRTRRGEKVCMNVPMYKDIATPETDDSIYDRDWFLPEDKEAKLASKPGFIYMDSMGFGMGCSCLQVTFQAPNINKARYLYDALVNFAPIMLAFSAAAPAFKGWLADQDVRWNVISGAVDDRTPKERGVAPLLPKYNKNGFGGIAKDVQDKVLEIPKSRYSSVDLFLGGSKFFNRTYNDTNVPINEKVLGRLLENDKAPLDYDLAKHFAHLYIRDPVSTFEELLNQDNKTSSNHFENIQSTNWQTLRFKPPTQQATPDKKDSPGWRVEFRPFEVQLLDFENAAYSVLIYLIVDSILTFSDNINAYIHMSKVWENMKIAHHRDAILFEKFHWKKSFRNDTDVETEDYSISEIFHNPENGIFPQFVTPILCQKGFVTKDWKELKHSSKHERLYYYLKLISDRASGELPTTAKFFRNFVLQHPDYKHDSKISKSINYDLLSTCDRLTHLDDSKGELTSFLGAEIAEYVKKNKPSIESKC
Protein: At2g17990 (Polyamine-modulated factor 1-binding protein) (Q9SL47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAGKEETDVSAQGSLTREATEIWRSELESRRFQVDSLEAELVDVKAYLEFGSEEDARKELGVLSGRVRSTATMLRYLRSKARVLAIPDDLANVSCGVEQIEELKGLNLVEKDGGSSSSDGARNTNPETRRYSGSLGVEDGAYTNEMLQSIEMVTDVLDSLVRRVTVAESESAVQKERALLGEEEISRKTIQIENLSVKLEEMERFAYGTNSVLNEMRERIEELVEETMRQREKAVENEEELCRVKREFESLKSYVSTFTNVRETLLSSERQFKTIEELFERLVTKTTQLEGEKAQKEVEVQKLMEENVKLTALLDKKEAQLLALNEQCKVMALSASNI
Protein: GH19226p (Q961K2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGGYEPNPILLEPVPKDFHFGLYELDWSVFETHVEGAQKLCPSYAKYGVKSTVCGPESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFGGGCGEQTALWVIQGQPDLPMFGFDLRRFTQEQGKAIQWIREKSHESYVKNYSMVFKYDQPLAGRDFQKDPLHDEMMKAGAVMEEKQGWERPGFFLPTGSKKAVVQPYDWYGSYVHQRHKDSEYERVLDGDLHYSRFSEYHDLIGSEALACRNNAVVFNMSYFAKLLLDGPQAQEAADWLFSANTNRDPSKTVYTCALNDAGGVEADVTISRLAPGSGEVYNPKINGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASLKDLTAELGVISIQGPNSRKILQPLIDCDLSDEHVAPNSTRLAKFGDVGLRLLRVSFVGELGYELHVPKKDCAAVYRSLMKAGAGEDLRNAGYRSLYSLSSEKGYHLWSFDLRPDDTPLEAGLGFTCRKTGADYRGKAAIENQRAEGLKKRLVYLTLRDQVPIWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQTYVSRPDGKIIDADYIRNGEYEVDILGKKYRADCHLRSPFDPTGQRVLGNYASESKSNK
Protein: Probable periplasmic serine endoprotease DegP-like (EC 3.4.21.107) (Protease Do) (G3XD20)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
Interaction partners:
- Sigma factor AlgU negative regulatory protein
- Positive regulator for alginate biosynthesis MucC
- Sigma factor AlgU regulatory protein MucB
- RNA polymerase sigma-H factor
- Peptidyl-prolyl cis-trans isomerase
- Alginate biosynthesis transcriptional regulatory protein AlgB
- Alginate biosynthesis protein AlgX
- Phosphomannomutase/phosphoglucomutase
- GDP-mannose 6-dehydrogenase
- Alginate biosynthesis protein AlgK
Sequence:
MHTLKRCMAAMVALLALSLAMTARAELPDFTPLVEQASPAVVNISTRQKLPDRAMARGQLSIPDLEGLPPMFRDFLERSIPQVPRNPRGQQREAQSLGSGFIISNDGYILTNNHVVADADEILVRLSDRSEHKAKLIGADPRSDVAVLKIEAKNLPTLKLGDSNKLKVGEWVLAIGSPFGFDHSVTAGIVSAKGRSLPNESYVPFIQTDVAINPGNSGGPLLNLQGEVVGINSQIFTRSGGFMGLSFAIPIDVALNVADQLKKAGKVSRGWLGVVIQEVNKDLAESFGLDKPSGALVAQLVEDGPAAKGGLQVGDVILSLNGQSINESADLPHLVGNMKPGDKINLDVIRNGQRKSLSMAVGSLPDDDEEIASMGAPGAERSSNRLGVTVADLTAEQRKSLDIQGGVVIKEVQDGPAAVIGLRPGDVITHLDNKAVTSTKVFADVAKALPKNRSVSMRVLRQGRASFITFKLAE
Protein: Histone-lysine N-methyltransferase set9 (EC 2.1.1.372) (Lysine N-methyltransferase 5) (SET domain protein 9) (Q9USK2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form H4K20me3. H4 'Lys-20' methylation is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response by giving a 'histone mark' required for the recruitment of the checkpoint protein Crb2 to sites of DNA damage.
Subcellular location: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Interaction partners:
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- Histone-lysine N-methyltransferase, H3 lysine-9 specific
- Histone H4
- SET domain and MYND-type zinc finger protein 6
- PWWP domain-containing protein 1
- DNA repair protein crb2
- PWWP domain-containing protein2
Sequence:
MRQTNTHLETFSLFDDVCTCLLVDKVFYWSQIHKVRKLVDRSIERMESCSIINIITKYIIEQTDLDQAAKNILQFRELDPLLRRLSSTSLLAFTRHLKYYLSLYLPSCKFEICSTNQYFSSSKPEACVIARESINAGEDITDLCGTIIKLSPKEERNIGIGKDFSILHSSRLDSMCLFLGPARFVNHDCNANCRFNTSGKRIWLRCVRDIKPGEEITTFYSSNYFGLENCECLCVSCERMGINGFKKLFHTSATSTSCSSKSSSDVSDLSSLPQSNRYVISEEDRSFLNIWDSGGELSDASSSDLDEEFSLFIPRHKKRVWSREKRLLSEMAITNHSPLLNVDDYRKFREDLWKKRHGKRKVYQCSNCSQTFINEDIQNSSAFCPKCIRHSKLFSLPWPCRHKVNRELKLEKEKEINTKRNLVTSSHSMSLRHKKAVDYQS
Protein: High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (EC 3.1.4.53) (Rolipram-insensitive phosphodiesterase type 7) (cAMP-specific phosphodiesterase 7A) (O08593)
Organism: Rattus norvegicus (Rat)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q13946}.
Interaction partners:
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenosine kinase
- Adenine phosphoribosyltransferase
- GTP:AMP phosphotransferase AK3, mitochondrial
- Deoxycytidine kinase
- Adenylosuccinate lyase
- 5'-nucleotidase
- Adenylate cyclase type 9
- Adenylate cyclase type 5
Sequence:
DQTALYIRMLGDVRVRSRAGFETERRGSHPYIDFRIFHAQSEIEASVSARNIRRLLSFQRYLRSSRFFRGATVCRSLNILDEDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMVKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRHEMEAQIGALILATDISRQNEYLSLFRSHLDKGDLHLDDGRHRHLVLQMALKCADICNPCRNWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIGFMTYLQEPLFTEWARFSDTRLSQTMLGHVGLNKASWKGLQRQQPSSEDASAAFELNSQLLTQENRLS