wanglab/gogpt-training-data huggingface dataset:
Protein: Small ribosomal subunit protein uS7m (37S ribosomal protein S7, mitochondrial) (O13744)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein bL17m
- Elongation factor 3
Sequence:
MLRLIKQPLFRCASSGHLMKESLVFIHQTRTFQVGKFTSNEKYNEKIEDINERSNPQWDNAGLENLLNQLQDSVEQSASDDFMGELEKKIEVENEEPPLMGTNLWPSPSSSIVGLIDRPFQVDSTVQHLVNLIMRDGKKAKAEKIVATALSIIQKETGENPIDVLKQAIAEISPLMKLVSAKRFNKSVEFPMPLKERQRRRIALQWILGECKSSSPKRLSDRIVKEIIAIRSKTSNCFKKKDHLHRMCLVNRGNAPVRI
Protein: BCL-6 corepressor (A0A5F9ZGX7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLNINGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKAL
Protein: Bromodomain PHD finger transcription factor (F5GXF5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAPGRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEFPKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDFCAALVSQEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENKIKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQKNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQLAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNKARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEEPTEVGDKGNSVSANLGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASELPQDVPVGDFKSEKSNGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGKEVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEGKYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKVLTISTLRLTITQLENNIPSSFLHPNWASHRANWIKAVQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYRVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNINKIIPENDIKSLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAEGNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTVITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENCAKSTVTTTTTTVTKLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVTSMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGTTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEEELELWEIRAFAERVEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTISPAQKVMVAPISGSVTTGTKMVLTTKVGSPATVTFQQNKNFHQTFATWVKQGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVTIRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLGKAIIRTPVMVQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSATSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPLATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQ
Protein: Fibroblast growth factor (FGF) (Q1XG76)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 1-A
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor 3
- Fibroblast growth factor receptor.
- Fibroblast growth factor 23
- receptor protein-tyrosine kinase
- Fibroblast growth factor 17
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor receptor, beta polypeptide
Sequence:
MCKWTPTTAGLHFAGSAPPSYPATLVCLSLLSLACSALGGCPPALGHDPLHALAQGTNCSWTLERHTRSYNHLEGDVRLRRLYSANKFFLCIDKTGKVDGTRRKNYADSLMEIRSVSVGVVAIKSVSTGLYLAMSKKGTLFGSARYNPSCKFKERIEENGYNTYASLRWKHRGRQMFVSLNGRGKPRRGHKARRRHPSTHFLPMLPT
Protein: DnaJ homolog subfamily A member 4 (Q8WW22)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Heat shock 70 kDa protein 1A
- DnaJ homolog subfamily A member 1
- Heat shock cognate 71 kDa protein
- Heat shock 70 kDa protein 1-like
- DnaJ homolog subfamily A member 2
- Heat shock 70 kDa protein 6
- DnaJ homolog subfamily B member 1
- Heat shock-related 70 kDa protein 2
- Endoplasmic reticulum chaperone BiP
- Heat shock protein HSP 90-alpha
Sequence:
MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQQIGPGMVQQIQTVCIECKGQGERINPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRILVITSKAGEVIKHGDLRCVRDEGMPIYKAPLEKGILIIQFLVIFPEKHWLSLEKLPQLEALLPPRQKVRITDDMDQVELKEFCPNEQNWRQHREAYEEDEDGPQAGVQCQTA
Protein: Trace amine-associated receptor 1 (Q5QNN3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDIRINISHNGIWDKPFLCYEFSNRSCQKFVYPLETRIFLYILFSASSIITIIGNLLVIITVVHFRQLHTPTNYLILSLAVADLLVGGVVMPPSMLRSIETCWYLGDLFCKIHSSLDVTLCTASILNLCIISLDRYYAICHPFQYHSKMTSLATLVMIIICWTVSAVLGFGMIFMELNILGVEDFYYENVDCNGRCLVFQSREVAVFMSLACFYIPAFVMLCVYLKILHEAQRQVQAIQSVNSELKKEGKATKTLAIIVGVFLTFWIPFFLCNLIDPFIGYSVPPLLFDLFLWVGYYNSTCNPIVYAFFYSWFRHAFRVILSGGIFQSNSSRTILL
Protein: von Willebrand factor A domain-containing protein 1 (O88493)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
Interaction partners:
Sequence:
MRKHRHLPLVAVFSLLFSGIAMTRAQQHGVMEVNKRDIVFLVDGSSSLGPSNFNAIRDFVTRVIQRLEIGQDLVQVSVAQYADTVSPEFYLNSYTNKRDAVTAVRKMRALNGSALYTGSSLDFVRNNLFTSSAGHRAAEGVPKLLVLITGGKSLDEVSQPARELKRGSIMALAVGSKAADEDELKEIAFDSSLVFIPAEFRPAPLQNMLPSLMAPLRTLTGTTEGSKRDILFLFDGSVNVLGQFPAVRDFLYRFIEELDVKPDGTRVAIAQFSDDVRLESRFSEHQTKAEILNLVKKMKLKTGKALNLGYALDYALRNIFVRSAGSRIEDNVQQFLVLLVAGRSSDAVAGPASSLKQRGVVPFIFQAKNANPSELEQIVLSPAFILAAESLPKIGDLQSQIVSLLKAEQGSGPVSGEKDVVFLIDGSEGVRSGFPLLKDFVQRVVESLDVGPDRVRVALVQYSDRTRPEFYLNSHMDQQGVISAIRRLTLLGGTTPNTGAALEFVLRNILTSSTGSRIAEGVPQLLIVLTAEPSGDDVRGPSVVLKQGGAVPIGIGIGNADISEMQTISFIPDFAVAIPTFRELGTIQRVISERVIQLNREELSSLKPILTPSTGAGVGSKKDVVFLIDGSRNAGPEFQYIRTQIERIVEYLDIGFDTTRVAVIQFSEDSKMEFPLNAHFSKDEVQNTVRRLRPKGGSQVYIGNALEYVLKNIFQRPLGSRIEEGVPQFLVLISSGKYDDEVDDSAVELKQFGVAPLTIARHTDQEELVKISLSPEYVYSVSTFRELPRLEQKLLTPITTLTSQQIHQILASTRYPPSVVESDAADIVFLIDSSDAVKPDGIAHIRDFVSRIVRRLNIGPSKVRIGVVQFSNDVFPEFYLKTHKSQSSVLEAIRRLRFKGGSPLNTGRALEFVARNLFVKSAGSRIEDGVPQHLVLFLGGKSQDDVARHAQVISSSGIVSLGIGDRNIDRTDLQTITNDPRLVFTVREFRELPNIEERVMLSFGPSGATPQPPGVDLPSPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFASVIVDTVYEDGDSIRVGLVQYNSDPTDEFFLRDFSTKRQIIDAINKVVYKGGRHANTRVGIEHLLRNHFVPEAGSRLDVRVPQIAFVITGGKSVEDAQDVSLALTQKGVKVFAVGVRNIDSEEVGKIASNSATAFRVGSVQELSELSETVLETLHDAMHETLCPGVTDVSKACNLEVILGFDGSRDQNVFVSQKGLESKVDIILNRTSQIQRISCSGNQLPTVRVSVMANTPSGPVEAFDFAEYQPELFEKFRNMRSQRPYVLTADTLKLYQNKFRQSSPDTVKVVIHFTDGADGDMADLYRASEELRQAGAQALILVGLERVANLERLMHLEFGRGFMYDRPLRLNLLDLDYELAEQLDNIAEKACCGVPCKCSGERGDRGPIGSIGPKGISGEDGYRGYPGDEGDPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGELGEIGLDGLDGEEGDKGLPGSSGEKGSPGRRGDKGPKGDKGERGDVGIRGDPGDSGRDSQQRGPKGETGDIGPMGLPGRDGIPGSPGDPGKDGGSGRRGPAGAKGNRGGPGQPGFEGEQGTRGSQGPPGPIGPPGLIGEQGFPGPRGGGGTAGAPGERGRTGPLGRKGEPGEPGPKGSIGNRGPRGETGDDGRDGVGSEGRRGKKGERGFPGYPGPKGTPGEPGADGPPGPKGIRGRRGNSGPPGATGQKGDPGYPGPSGHKGNRGDSVDQCALIQSIRDKCPCCYGPLECPVLPTELAFALDTSEGVTQDTFSRMREVLLGIVGDLTIAESNCPRGARVAVVTYNNEVTTEIRFASSKKKSALLDSIQNLQVALTSKQQSLETAMSFVARNTFKRVRSGFPMRKVAVFFSNKPTRASPQLREAVLKLSDAGITPLFLTSQEDRQLINALQINNTAVGHALVLPARRDLTDFLKNVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDLAFILDSSEATTLFQFNEMKKYIGYVIRQLDLSPDPKASQHFARVAVVQQSTYESVDNASVPPVKVEFSLTDYGAKEKLLDFLSRRMTQLQGTMGLGNAIEYTIENIFESAPNPRDLKIMVLMLTGDMQRQQLEEAQRAILQAKCKGYFLVVLGIGRKVNIKEVYSFASEPNDVFFKFVDKSTELNEEPLMRFGRLLPSFVSSENAFYLPPDFRKQCDWFQGDQPVKNGVKFGHKQINPPHTANSSLTSKVVTTIKPSNSSKPTAIVNLTPAKPAPARPAPAQPVLAKPDPAKPAQARPAPAKPASAKLVPPQPVHVQPAPAQTASVRPAPAKPAPPQPAAAKPVPAKPAVPAQPAPPQPAAAKPVPAKPAVPAQPAAAQPMPAQPVLTKSAAVKPASANKPVAAKPVATNTATATARPALAAKPAAAKPAATRDPLAAAVRPVATKPEAPRQQAKPAATKPATTKPLARVSREVQVSEVTENSARLHWERPEPSSSFFYDLTVTSAHDQSLVLRQNLTVTDRVIGGLLAGQLYHVVVVSYLQSQVRAIYQGSFNTKKTQPPPLQAAHRASSSTINLMVNTEPLFLTKTDICKLSRDAGTCVDFKLLWHYDLESKSCKRFWYGGCGGNENRFHSQEECEKMCSPELTV
Protein: Eukaryotic translation initiation factor 2 subunit alpha (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) (P56286)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Eukaryotic translation initiation factor 2 subunit gamma
- Probable eukaryotic translation initiation factor 2 subunit beta
- Probable eukaryotic translation initiation factor 5
- Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit alpha
- eIF-2-alpha kinase GCN2
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit epsilon
- Translation initiation factor eIF2B subunit gamma
- Eukaryotic translation initiation factor 3 subunit A
Sequence:
MSTTSCRMYENRFPEVDELVVVNVRQIQEMGAYVKLLEYDNIEGMVLLSELSRRRIRSVQKHIRVGRNEVVVVLRVDKEKGYIDLSKRRVSPEDVVKCEERFNKSKAVHSIMRHIAEKHNVPLETMYTTIGWPLYRKYGHAYDAFKLAISNPDHVFEGLEPPKSGVINDLLAQISRRLTPQPIKIRADVEVTCFGYEGINAIKAALKAAEDVHTEEVPIKVKLVAPPLYVLLTNALDKSLGLKKLEEAIGAIEKSITASNGTCTVKMKPKAVSETDELELADLMKKFEKENAEISGDEEDDQSGSE
Protein: Kinase (EC 2.7.-.-) (C9JNA8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQEQVLWPWALH
Protein: Protein Hook homolog 3 (h-hook3) (hHK3) (Q86VS8)
Organism: Homo sapiens (Human)
Function: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11238449}. Golgi apparatus {ECO:0000269|PubMed:11238449}. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase (PubMed:11238449). Localizes to the manchette in elongating spermatids (By similarity). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449}.
Interaction partners:
- FHF complex subunit HOOK-interacting protein 1B
- AKT-interacting protein
- Protein Hook homolog 1
- Cytoplasmic dynein 1 light intermediate chain 1
- Protein Hook homolog 2
- FHF complex subunit HOOK-interacting protein 1A
- Protein bicaudal D homolog 2
- Kinesin-like protein KIF1C
- BICD family-like cargo adapter 1
- FHF complex subunit HOOK interacting protein 2A
Sequence:
MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR
Protein: Vitellogenin [Cleaved into: Vitellin] (Q6RG02)
Organism: Penaeus merguiensis (Banana prawn) (Fenneropenaeus merguiensis)
Function: Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.
Interaction partners:
Sequence:
MTTSTLLFVLAFVAGGLAAPWGADVPRCSTECPVTGSPKLAYQPDKTYAYAYSGKSTVQLKGVDNGDTETEWTAGVDLTWISPCDMAISFRNTKMDGARGPTAARTLERYPLVVAVVDGRVQHVCAHPEDEAWAINLKKGVASAFQNSIPSLSAVSSGITVTETDVVGKCPTKYEIETEGEKVIVVKEKNHRHCQERYPTPAALPAPWLKAPLPIEESKSQCRQEIANGIYTAITCQDKNIVRPAIGIYKYVEASQYSTLRFISESSDTSAISGIPSGELNIESLLYNHETMKDPQLAPELDELMKEICDKTKDTVEAEAGALVAKALHVLRRIPDTVVVETAQKVRQGHYCSDSARLESIFLDAVAFIHESGAVKVMVNEIENGRATGGRLALYTAALYLIPRPNIEAVKALTPLFESPRPMPSLLLAAATMVNHYCRHTPACYEKAPVARIAEILANRVQTHCSPSAGVEDNEVALAIFKTIGNMGVATPAVTRAAVHCIEVEGLETSVRVAAAEAFRQANCFRPAVEKLVDIAVRPAFETEVRIASYLAAVRCAEQEHLETIIEKISKEENTQVRGFVLGHLINIQESTCPAKENLRYLLANVIPTDFERDFRKFSRNIDVAYHAPAFGMGAGLESNIIYAPGSFVPRAVNLKMKADVDETHMDIAEIGARFVGIESIIEEPLGPQGYLRTATFGKIMEDITGFAGEKGYKVMEQLKHTLRTRRSIDSSVIADFFGKLYGKSRSHTHAELFARFMGHEITYADVAGSLKGVTADTLIETFFSFFENSLEHMKDLNLNTARTAQLSMDYSLPTIQGTPLRLRLAGTAVAGLKMEGNVNIAQILSDLGNSQTGVKFFPGLSVHATGFVGFDWLLARVGIEMQNTISSATGAAIKIRTTENKKIEMELEVPEKMELLNIKAETYLVKAVGKKMTEISPSSMRDVRIQRNSCIGALEPVFGLKVCYDMNIPDVFRANALPLGEPAIAKLYVEKADPSMRGYLVTAAIKNKRGNKVIKMNVEAAGASTPRRAEMTLSYTKEEGSHIVSAKLDSSSIAAGVWTTLTNEQGHKAMETYVNFNYGQIAISRGIKLEAIAREASVGEEFQVNVFSSGTRSFPSESHIVEARFIKKTSGPEFNVDVICRTKNALAELFDLNIEVGADFMKFSPKNLYPARYIPKTRIVLPVNLRKMEINAATAAWKLISYIRAGSQSGGSREFISALKLAKGRKDFISVQATHTIEGTFPQNIIIKNVATAEVGRSSYKAMYDLFYHSEKMGASLEVLQAAGNEKVAHLEAIYELSGSKYCTKFLAEIPGYIQPVKVEAGIEQGAEGRYTLESAITYGQRTVLEASGPIMARFSSKIAKLQANIKVRAMASEPYIIGANVAFGSKKQMIAMEIKGRSEAVIGLEWKMVRESSEKTTVGIVFVLPALIENKIDAEITDGLIHVSFNNLVLPKTSSRRRVKGFADVHIAEKKANVEFSWDADNAPEKKLVLDASLISSSANPGHAEIHGNIVIAGEPFHAKLVLTAANLVEHMEGENGFKLILTTPSQKTIVLGASCDVQVAGATTKVISTVEYKNMKDRKYKYASVIAYEKLGGPFDYAVEAKVTYKQPGTAEIKLGTAVKHHWTPEEHVVAVRVEADAPILKTPATIEFSIHNAPNAFVGFCKIERNAPATVFEWNVQITPEGGIEAVEAGVDMKAIIEVLKIVHAAATLQEESYETYGPHTSQYQYRFTRPSPTSYTMQMRTPTRTMEGRAKLSPRESGIKFYPNKGKTESKYEIGYKANHEGRWGGHASKLEVRMNHPVLPKPIMAAVQYTVAEETTKGTIELDIFPEEANKITGSLETQRISENAIRAEAFLTSRMLKVNPKAIITAAYAPETVAFDVVFHKTPSAAPIFAIAAKYDKTAAHNAAATFTVKMEERPVFEITAVTEPEEAATCNGIRMRAVAYAATFGKYNVISKMCRPAFIEVTAMRPGGAKEYIAKLGLRYPDAAEAGVYVASGRAGETHGVAVAAVKLASPTMLKVEMAYEPQEAEAIINEMTEEFEKIAASFTSVEMEVVEFLKQEAAAKGIQFPSSQLVNLLGVAKEEIAEIYRDIVSEAIIFDTEILGDILGSPVVSFISRVYFGVWSEIIHLQHHLSVSLIQTIERFQQELGSISEILMEVVMTAARMAETGEVPGVVFDALEEIKATKVFRIVRREVDAILEEYPEEYEAVKHIVHNVVAILKRDVGIVRERLMEIPAVLKIIDYTMYHFHSERAFAAEAEKLVSLMLNELLFVSMEREGNGVAVRIPLHRPLYSLTQVAQEAVPNPVTMLENLIFAYVDYIPIPVSDAIWAFYNLVPRYITDVLPPYPRTATVVGGSEILTFSGLVVRAPRSPCKVVLAAHGSHRLMMSHPQASAPAQFELKTPAATVMIKPDFEVVVNGQPLAGSQQTIGNVRIVNTAEHIEVGCPLMKVVVAKAGEAVAVEASGWVFGRVAGLLGPNNGEIAHDRLMPSGAAASNPRDLVAAWQEDRQCSTPEVPRAETTVARLIQCEALLGIRSRCNPVVHPQPFIKMCHAAHKACDAAQAYRTVCSLRGVGEVFPLGC
Protein: GTP exchange factor for ARFs 1 (P34512)
Organism: Caenorhabditis elegans
Function: Promotes guanine-nucleotide exchange on ARF. Promotes the activation of ARF through replacement of GDP with GTP (By similarity). Plays a role in cell shedding during embryogenesis, probably by promoting the endocytosis of cell adhesion molecules.
Interaction partners:
- ADP-ribosylation factor 6
- E3 ubiquitin-protein ligase arc-1
- C2H2-type domain-containing protein
- ADP-ribosylation factor 1-like 2
- Exchange factor for Arf-6
- Guanine nucleotide-binding protein alpha-5 subunit
Sequence:
MSSRYSERNGLSETEKMTLPKVRKRKAQLVDEIEALKNEVREVDEELDQVYYTHPKSKEYHKIVVNGRKKFNQDPWKALDWLASRNVVAKDPQALALWMKAGEGLSKSAIGEILGDNRPFALETLDRFTKEHKLHDVPIVPALRQYLFSFRLPGESQKINRILEKFAEVYANQNPSYGNADQAHTVAYSCIMVNTLLHNPNVKDKPSLEKYIEMNEQLLEKGAITIEQLTEVYESVSVTQFKIPDEVSTSGKGTVNDILLHAEREGWLFKQSSNPLFSGALSWKKRWFVLSENCLYYFDQMTDKEPKGIITLANVGIRKVEAPSRPFMFEIFSLSDGQIKACKTEQDGRLVEGRHSIYKICAVNDEDMRSWINAISRMMAPQQHLLARPKSTH
Protein: Claudin-18 (P56857)
Organism: Mus musculus (Mouse)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier. Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency.
Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:11585919, ECO:0000269|PubMed:29400695}. Cell membrane {ECO:0000269|PubMed:11585919, ECO:0000269|PubMed:29400695}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to tight junctions in epithelial cells. {ECO:0000269|PubMed:11585919}.; SUBCELLULAR LOCATION: [Isoform A1.1]: Cell junction, tight junction {ECO:0000269|PubMed:22079592}.; SUBCELLULAR LOCATION: [Isoform A2.1]: Cell junction, tight junction {ECO:0000269|PubMed:22079592}. Lateral cell membrane {ECO:0000269|PubMed:22079592}.
Interaction partners:
- Pulmonary surfactant-associated protein A
- Surfactant protein C
- Secretoglobin family 3A member 2
- Advanced glycosylation end product-specific receptor
- Pulmonary surfactant-associated protein D
Sequence:
MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVTAVFQYEGLWRSCVQQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGVIGILVSIFALKCIRIGSMDDSAKAKMTLTSGILFIISGICAIIGVSVFANMLVTNFWMSTANMYSGMGGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLTPDDSNFKAVSYHASGQNVAYRPGGFKASTGFGSNTRNKKIYDGGARTEDDEQSHPTKYDYV
Protein: Uncharacterized RNA-binding protein C23E6.01c (O60176)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Pre-mRNA-processing factor 39
- U1 small nuclear ribonucleoprotein C
- U1 snRNP-associated protein usp107
- U2 small nuclear ribonucleoprotein A'
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- U1 snRNP-associated protein usp106
- U2 snRNP component prp10
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein E
- Splicing factor U2AF 59 kDa subunit
Sequence:
MSSSPTESEILPKESHNSIDEQSQQPANTDTLVKDNSFNEQDDQEVDNDYKSNDEPVQSQDPISPNMASNESGNSENTSNYGSSRDENVYQKTTLWMGELEPWVTEAFIQQVWNTLGKAVKVKLIRNRYTGMNAGYCFVEFASPHEASSAMSMNNKPIPGTNHLFKLNWASGGGLREKSISKASEYSIFVGDLSPNVNEFDVYSLFASRYNSCKSAKIMTDPQTNVSRGYGFVRFTDENDQKSALAEMQGQICGDRPIRVGLATPKSKAHVFSPVNVVPVSMPPVGFYSAAQPVPQFADTANSTVFVGGLSKFVSEEELKYLFQNFGEIVYVKIPPGKGCGFVQFVNRQSAEIAINQLQGYPLGNSRIRLSWGRNQNPIAAPALNYQSQVSQTTIPATSLFPAMSLPPQAQFSPYPAVAPSPLALQTRGAPIGMEISIGSPALVPDQMHIPENGNSDTMPVPNTQGKHLSAEE
Protein: Mekk1, isoform B (EC 2.7.11.25) (SD09178p) (Q8MSQ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- mitogen-activated protein kinase kinase
- Dual specificity mitogen-activated protein kinase kinase dSOR1
- [Pyruvate dehydrogenase
- Mitogen-activated protein kinase p38b
- Peroxiredoxin 2
- Activating transcription factor-2
- FI09246p
Sequence:
MSNRRRVRTIDYLALQQSLRLQKTPAATTNAEEQVAREEENGNGHHSTVTAETPPTPPIPPIPPIRLRREQSVEEDVARVEYRVKQTPSRPVQMTRNRIGALEEDMPPEDELAAHYEAFGTTPPRTRLKIKNRDWERKQKVVNVTASADLPASVGGTPKKTRTARSRVLRRNTMDCALLNEMFVNDESKRTDKRLQSLLRDSEREMKNSLATTAVAAPRGNSFHETAHPLESLDQIMPLNSEAMAPIPLRIASKVVESCNRYRCVSSRPIGYRSSAPPLAFAAQLPAGMLRSDGRATPGLGKRKDFHETFANLIKLGSVDRQDAKLSQEEHTWQTELKDLIWLELQAWQADRTVEQQDKYLFEARQGVSDLLTHIINYKFQPRYRREPSLISLDSGTHSDSNSNASSPLPSKMCQGCMSLYCKDCMDHQELALREVEGMLTRLEAAEALYPSSQAMGALHPIYKSQSFVGRIKSMCLWYNITKQNKLKLSILGKILARLQDEKFSWPVCTSSYIATDSGSSSASGVENDDSAVNSMDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQWSSECSHSHMRKGSMHDINIFSVEPLGTCSSNGTGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVALYKAHIALEKPGAEDFDYESDAESIEEDVPRLDPEISREQVVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEFLRMRLETRPVRPNPLSLEQLMKELREGLTLALTHRERYQRHITTALVENEAELGSYISILNHYDATVRKTFELYLEYIDQLVLVAVPEGNQKSVLEKEWMFTKLISPMIKGMHTLASQKFCGIISKLLRSISERLVKRTVELDQQIDGTADTDDNEEVKWQLLTICRETQSLLTVERERSIKVLFFAKTFCRDVETTDFHREHYEHDVANQQHDFICSDVKAAFKLLQQDVLQVRNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEYHKDVIRLFEQKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVLNPNTPPLQSPPYNKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDECSSEQLQMQVRGSFRRNVATSSS
Protein: Vacuolar protein sorting-associated protein 16 homolog (Protein maroon) (Q9VHG1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Late endosome membrane {ECO:0000255|PIRNR:PIRNR007949}; Peripheral membrane protein {ECO:0000255|PIRNR:PIRNR007949}; Cytoplasmic side {ECO:0000255|PIRNR:PIRNR007949}. Lysosome membrane {ECO:0000255|PIRNR:PIRNR007949, ECO:0000269|PubMed:24554766}; Peripheral membrane protein {ECO:0000255|PIRNR:PIRNR007949}; Cytoplasmic side {ECO:0000255|PIRNR:PIRNR007949}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24554766}. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes (By similarity). Autophagosome localization is dependent on Syx17 (PubMed:24554766). {ECO:0000255|PIRNR:PIRNR007949, ECO:0000269|PubMed:24554766}.
Interaction partners:
- Vacuolar protein sorting-associated protein 8 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting 33B
- Vacuolar protein sorting-associated protein 39 homolog
- Vacuolar protein sorting-associated protein 33A
- Ras-related protein Rab7
- Vacuolar protein sorting-associated protein 16B
- Vacuolar fusion protein CCZ1 homolog
Sequence:
MPIMYNTGEWFKVRPDYYRKVELATPDWPLDLDLEYMWVEVAPYGGPLAVTRDPTKLVPVKGNARPMIRIFDTTGREMGHILWNHGKLIAMGWSDMEELICIQENATVFVYDMFGREKESYSIGDEASVTKIVEGKVFQSSAGTGVAVMTTSGRVFLKQNSSKTERKLPDIPNSSMNCSCWEIVTEGRNSYCLLGRDREVIKLFPGETVGTITANLFEKPHERIIKISVSYNHQHLALYTNTGLLWLGSVDMRQKYCEFDTGRKDMPLQMEWIMNSDNSEADAVVISYPSYLLIVNRNADRSDFPYDPVMFLVAEMDGVRIITQSSHEIIQRLPKCVENIFAVNSQEPASYLFEAQKKFEEKSYKSDEYLSMCREKIDLAVSECIEAASYEFCPETQKSLLRTAYFGKGFIRNHNPDEYMRIMRILRVLNTLRHERIAMPITFKQFSHLNTEVILSRLVFRKHYAIAIQVAKHLNLPESWILEHWAYHKVMNDPNDTEVARKITEKFKNPSVEGISFCNIASKAHQAGRDDLAIKLLELESRASLHVPLLLKMRKFDRAVGSATQSGDTELITQVLLEMKMHMMLSNLHMTIRDHPLALNIYKKIMRESNRAGLYGIYNTEDDQKAIAEYHFQNAIETEGLESNLSMIGNAYAQGRCTLEAELCADTSRLIKLQKTLSTKYNVSLNGLSIHETIQELLLIGELKEAERIRSEFKVPDRRFWWLRILTLSSQHKWEELEKLAKSKKSPIGYDPFVEVCLKQDNVMEARKYIPRCRDNRRVVWYMRANLFNEAIDSAFEQRDVHSLFELQKNQAIVNNGTLLSKVCDCIAMLEGK