wanglab/gogpt-training-data huggingface dataset:
Protein: Trafficking kinesin protein 1 (A0A8I6A6Q8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MCALGPDGSSGQVAKGSPKDSPLGQCFRFGVTSTMSLRDVGGEEECFEYNCQDEETAATPEQHGTLDILAATQEQGDPVDILEDVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEACQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKSCAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEPESPDITHQKRVFETVRNVNQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDVSHVVLDNKTNSILLETEAADLGNEEHNKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLRELAEKGELHSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLAGLATSTTIQHMETSGERSRAHVTVSGSRSYSSQPQASPEEMHQPPEQAGLEEEEEEEEEEGSGEGTSISPVNLTPLPEAELWAMLISVPGTTRSNSVSVASARLCG
Protein: Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21) (Q9BY50)
Organism: Homo sapiens (Human)
Function: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13679}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P13679}.
Interaction partners:
- Signal peptidase complex subunit 2
- Signal peptidase complex subunit 3
- Signal peptidase complex subunit 1
- Signal peptidase complex catalytic subunit SEC11
- Alkaline phosphatase, tissue-nonspecific isozyme
- DNA-directed RNA polymerase II subunit RPB7
- Protein transport protein Sec61 subunit gamma
- Protein transport protein Sec61 subunit alpha isoform 1
- Protein transport protein Sec61 subunit beta
- Large ribosomal subunit protein uL24
Sequence:
MVRAGAVGAHLPASGLDIFGDLKKMNKRQLYYQVLNFAMIVSSALMIWKGLIVLTGSESPIVVVLSGSMEPAFHRGDLLFLTNFREDPIRAGEIVVFKVEGRDIPIVHRVIKVHEKDNGDIKFLTKGDNNEVDDRGLYKEGQNWLEKKDVVGRARGFLPYVGMVTIIMNDYPKFKYALLAVMGAYVLLKRES
Protein: AT17006p (Q5U0U1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MCSIFRNRINYRGTGGTRSGSGERERDRDRDRDRDRDRERDRDTLLAKELDADSNNNGTEPQMEAEAVPESDTERETAEERGEEQEPENSNEALDLSLISSGGRESLPGSGHVSLEALQHTKVAVAQFAATAMAGNHQSADLAMVQSTIFNVQRQHLMQLQLIQHLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQDQESRREENSKTDKRGTEDRKAEPEGYQSMMCDISSSLASSIITNHDPPPAPNEPNCLEMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRPHCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMRPGPNSGQGHPGSSAEQEFMQRRPELFFPYLPPFFNGLPPKPGELSPGAFPNIPPPPFANGGKYPYPPGLLGFPGFLAQHPYGLERRSSSKSPTPEPAQSPALREEEGSGNIWHPLSRIKVENNQNESMGGFNEQEDHAETDATGGDNDESESRDAEK
Protein: GH21228p (Q95T55)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MCSMYAFPLIMFIYCYGAIYLEIYRKSQRVLKDVIAERFRRSNDDVLSRAKKRTLKMTITIVIVFIICWTPYYTISMWYWLDKHSAGKINPLLRKALFIFASTNSCMNPLVYGLYNIRGRMNNNNPSVNNRHTSLSNRLDSSNQLMQKQLTNNSLLNGRGQVMAAAVSATTKLANVVSLKGTANGNGSAAAAGTVPITPPLTVTIAPLATDDEANDDSCLSAVTIRCQDQSPIRQK
Protein: VASt domain-containing protein (A0A1D8PE20)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Calcium-channel protein CCH1
- Ino2p
Sequence:
MALKLLGKKSSKVKEEEGDNSIDTTESTQSKSPSKHHRRSFNIFQYQNHRNSQGSSDNSFEFRGMVNALNRSHSTSKKTRPLSLSPQKSNSLIVSSSNSSKVKKPKLSTADTSYEDRRYNLPENQETQTDIDQSSHDKMNSMEDRIALRQDQNDPAISFDVKLASAQGSELLLNPPTKDTTDRSSTTSSFKQPFPHSPSKSQLSNQETGTSPQPQPPKSESNGFLSSLLNAAANKMISSTPPSPPPEDKKKDHSFSSKLDTLLRGVKHEGSKSSLVDGAATASADVDSLENKQITNSTELKSIHSLTHDVQFEPVRESPLNTLGNGDLSLADFDNKFAREELGMGSRRPSFRSADSITKRATTPELMPNSGSLNGGDTRRLLSRSLNRSNSSLISIPQRPSSLGKSPVADSRMAKSSDDPNRNSTITENGRVDDNDSGVLPGNFDTENIEDIVDYTKKIKHASKKRNKEFHQNFKKLPTKEKLIDDFSCAVSKDILVQGKMYLSDHYVCFNSNILGWVTNLVIPLQEVIQIEKKSTAVLFPNGIVIRTLHQKYVFATFLSRDSTFDLITNVWHRVLLENSDIDPKKLQAQINKGKRRARAGSRVSNFSSTSRDDDTNSLDISDSDGLGGSDEDNDNSSFDEDEDANDSGHDASLESDDFESDGKPSDASESKDGDVAATSGSGNTFKGLPIVGPLTHAPTETGYSKESSETFISEDTIKAPPGAVYLIMFGTDTSKYIRILKDQKNFDISESKIKALTKENKERSYTYTKPLSGPIGPKQTKCNIEDKLIEYQPEKFYEVEQTTQTPDVPSGNSFKVKTKIFLSWAANNETKVYVVTSIEWSGKSWIKGAIEKGTIEGQKDSMKSMISTINSIVSQGSDKKEGANGKRKSRSRKGTLKKEQEEEEVIKVEQSETPKSISEQFMTLVDTIGGLIPIPFLSNTVVGFIIVLIGFLTTVSVFNRLTSTSPKQYIELIPNDYLYASRIQIRDNKYLLLPTVETSFKNERLKRQEELSLWSWLNNRSEGRLNLNYKAPSLDELDDSDLKSKYGEQELKEIVRLTRIKLDKLSEKLDDL
Protein: Transcription factor 25 (Q38EB2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- E3 ubiquitin-protein ligase listerin
- Translation-associated element 2
Sequence:
MSTRQIRRLQNIVKASTGADADDEDYHPPTMKLPKSVGKSKAQRKAPAGAAGDNQPQEQQPKKAAETSTTGASPRSLECDGTNDEDRQGLVKQKPTRKTTVRPKSEYDNAMEVEGKDLSFNATSQQQQIVQREQCKKKRQNKRKKARRREEELEEELLLEAALREREKDTANNAFRRNGAGDAEGSEDLLGLLSLCNPQMLNSRSERIRRFGAAAVEDLGDGRTPTRRPESRPTSQLFEEHMHNLPRFRSSVLSTPNRYCWPRYDGLGTKLVLRKPGMDDHDDIAGNGSNRTKVYYLDVSAPESQRADADLAECEKLVDAVDGLMGCLGKTPYHIPTLIVVSNVFETMGNVPRALEVIDLALYHLGVLLQSFPLRQTARQRCVPFSIPSNKQLFQVLRCGIHHALRKAAVRTAWETCKLLYSLDPKDPFGSLFLLDYLALRSKGWAWLVHVYYLLIRESCRIPNSRTLPPTAECVNSGCSNLSNHELALSLSTLPGFFFSAALAKLFLEREEATHTQKGGKLSRVIRDISPAELHAFHDTPPSGVMLADAIGRFPSAAVLLVEKVGSQAQPSVAPAAWKEVVKGHMNNNGGQRLRVATLWVARNAEMWNAAEPSGFLRRVITEESGVYLKSLSVSAANPCADVPTPWEHEMLREEDLMGTVMAAIPAHLLDPNEVTAEDAREEAWRVGQRALTPSEQDMLLRFRALYGELPPTVGTPVEQLALYEMMFETDGRELQMVQQQNHIALFLRTFLPWNNTRDMALREALRAAGIDDPVAGRNRQRRLEEIESDEPSDTSEWVTDSSWNTEESSFSLEDAIDGDDEWFWRTRGSQ
Protein: Uncharacterized protein (Q38D42)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQCNMKTWIILVTLSFFSLVVTRAVVADCIPEKRSTLTSQCPSLPLVHHFHYRLARRMLPSSLFCSALCQKPWSSFDEQSLRLEMEQWIRANRTVGMFPEAHNFVMDEVLRLTNNLEGIANDTEDVRTVYAKRVKETYQNMPWLMVKPGIIAQATEYYAWNVRGRHIVRAINLEEQDSEPEQIAHYVQAVREWWLEAQAAVARDRHVGPPYIPWVDLERLIGPHIEPPVLFSSSNSTGTHNQSGKSNIGLPREFFRRRSYPYLPPPLVTPPALVYYYSDNCKRCRDYNIMFDLLPFLYRRLCEHGHMSVVSCSPVLMLFRAKAPRSQLLVPRIRFYGVPCRLEVIHIAPTVKVFASELPGRRFCDPLESVEITIGSQKDIESMLVSLFIQLIRLDVINMRVVTKDALDDMKREEEEEERNDKQRERLTKGGNLSNGTKEKGNNTNSKRQRKASFMTLRDGIRELLRSHVNETWGGGADILRAADEVTWMQVYPMWFNISVMGLVGLWAVLLLWRSYVEPS
Protein: GDP-mannose transporter (GMT) (Q5A477)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Involved in hyphal formation.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:11741841}; Multi-pass membrane protein {ECO:0000269|PubMed:11741841}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:11741841}; Multi-pass membrane protein {ECO:0000269|PubMed:11741841}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11741841}; Multi-pass membrane protein {ECO:0000269|PubMed:11741841}.
Interaction partners:
- GDP-Man:Man
- Mannan polymerase complex subunit MNN9
- Ubiquitin-like modifier HUB1
- Yea4p
- Dolichol-phosphate mannosyltransferase subunit 1
- Alpha-1,6-mannosyltransferase
- Kre5p
- Van1p
Sequence:
MGVISFYLIGQLLYLIRKKYTTTYRQQQQHQYNMDSKHSTSSSSSGSLATRISNSGPISIAAYCLSSILMTVTNKYVLSGFSFNLNFFLLAVQSIVCIVTIGSLKSLNIITYRQFNKDEAKKWSPIAFLLVAMIYTSSKALQYLSIPVYTIFKNLTIILIAYGEVIWFGGKVTTMALSSFLLMVLSSVIAYYGDNAAVKSHDDAFALYLGYFWMLTNCFASAAFVLIMRKRIKLTNFKDFDTMYYNNLLSIPILLICSFIFEDWSSANVSLNFPADNRVTTITAMILSGASSVGISYCSAWCVRVTSSTTYSMVGALNKLPIALSGLIFFEAAVNFWSVSSIFVGFGAGLVYAVAKQKQQKEQSQQLPTTK
Protein: Protein brambleberry (I6V1W0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for nuclear membrane fusion during karyogamy.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:22863006}; Multi-pass membrane protein {ECO:0000269|PubMed:22863006}. Note=During metaphase, localizes near the mitotic spindle region, and its localization shifts to the chromosomes as they reach the end of the spindle. During karyomere fusion, detected in prominent puncta, mainly at karyomere-karyomere interfaces corresponding to putative fusion sites.
Interaction partners:
- Bloodthirsty-related gene family, member 26.
Sequence:
MALWFVLLWVSSLQYAEVEAFFDWLKKADPAPTPPPAESIVPILLHGEAPAFEMSVVDEKFLAEAKQMELSPLDSCHFRVVAQLKATCSGLSEEQLAKLGVALFNCQSEVEGRRTYPCTEEMSIKECTADMDSDTWNAYHIVSNRARSVCYATRQQHFRKRAELTVNALISTATSQLDAMKDLKEGQKELRDMTAASLDKLLEGHGALQIQQGALKEGQEQLDASISENLQRLAQEKALISTGQQLVAQLIQGITQRMENVSGQLKDQTAEVQEGHQAILEDLAVVRGSAQDIYEKMELNLNGFLQQQNTTAHFYTELMRKLELMNGTLGYMLTYLDNMQTRLEDRLHMIQGYLGWAGLSLRALWTCVMHAGYFLLCAVLLSFLQCTTFSRVTLLLSVPINAIAEINQQAALDLISLTLLLFTLSLGRWFVLQLLWALSKIKGRTCSRPPHLSIYPPKEKTPEKQHEFGEKCPASSSTPVQSDPVCDLEVESFMMGDPCVLGVSPSRCPPKFSHHHLGGTPNHSTPRLKSRHSIAATELDNIPQRNLGVFLETVNRSRSSSPNQSLASSSSFSGRSLCSGITRLGQPCKKRAVVGQDYCRVHEGGHTSYSRL
Protein: Tetratrico peptide repeat group 5 domain-containing protein (O33193)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- D-glycerol 3-phosphate phosphatase
- NAD kinase
- Uncharacterized protein
- DNA repair protein RecN
- 16S/23S rRNA
- Chaperone protein HtpG
- Alanine--tRNA ligase
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit omega
- Pre-mycofactocin glycosyltransferase
Sequence:
MVDDRQGRRGGRRPRSAAADNRPAFRDGPAIPPGIHARQLAPEIRRELSTLDRATADAVACHLVAAGELIDDDPEAALRHARAARVRASRIAAVREAVGIAAYRCGDWAQALAELRAARRMGSKSPLLALIADCERGLGRPQRAIELARGSEAVELSGDAADELRIVAAGARADLGQLEQALTVLSTPQLDPGRTGSTAARLFYAYAEILLALGRGDEALQWFLRSAAADIDGVTDAEDRVDELGAREQK
Protein: Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) (Q9UM22)
Organism: Homo sapiens (Human)
Function: Binds anionic lipids and gangliosides at acidic pH.
Subcellular location: Lysosome lumen {ECO:0000269|PubMed:30729188}. Secreted {ECO:0000269|PubMed:30729188}. Note=Lysosomal and also secreted. {ECO:0000269|PubMed:30729188}.
Interaction partners:
Sequence:
MPGRAPLRTVPGALGAWLLGGLWAWTLCGLCSLGAVGAPRPCQAPQQWEGRQVMYQQSSGRNSRALLSYDGLNQRVRVLDERKALIPCKRLFEYILLYKDGVMFQIDQATKQCSKMTLTQPWDPLDIPQNSTFEDQYSIGGPQEQITVQEWSDRKSARSYETWIGIYTVKDCYPVQETFTINYSVILSTRFFDIQLGIKDPSVFTPPSTCQMAQLEKMSEDCSW
Protein: Euchromatic histone lysine methyltransferase 1 (A0A0D9SFG7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQ
Protein: Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] (Q8BJQ2)
Organism: Mus musculus (Mouse)
Function: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O94782}.
Interaction partners:
- WD repeat-containing protein 48
- Fanconi anemia group D2 protein homolog
- Fanconi anemia group I protein homolog
- E3 ubiquitin-protein ligase FANCL
- E3 ubiquitin-protein ligase RAD18
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-B
- Proliferating cell nuclear antigen
- Polyubiquitin-C
- RAD51-associated protein 1
Sequence:
MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKTSEYRGSEIDQVVPAAQSSPVSCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKTGVKHLFNIISRKKEALKDDSNQKDKGSCKEESLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGFLQHDAQEVLQCILGNIQETCQLLKKEEIKNLAELSGKVEEQSLQKEETGGITSTEIDSMRNTEDVKEQLPKGNWKRKSDSESSNVKKKVKLSRESQPLEENQRQTRSKRKAIGDTLEAAPKIIPKCVSESESAKPSQKKSKVKINWLKPSTKQPSILSKFCSLGKITTNQRSKGQPKEKEGDVEEDLEKYGSDHTANGGPESPGSSVTPVDSSEAKSGNKGAEQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDEGNFVVDQMCELGKPEPLTEEQARGTAGNYDDEVSIRVGGNAQPSKVLNKKNVEGIGLLGGQKSKADYELYNKASNPDKVVGTPFTDNRNSETNDTTNGTHESDRNKESSDQTGVNMNGLENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL
Protein: Uncharacterized protein, isoform B (M9PCM0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKTSKTLIFIIAIFLISHLSLSKKRNSQFNQVQHEHYIKTSECHIPYINKPLENEKGNIKKQHTICSKDESLINLRFDEKSHQYLLYVNDHVAQLKLRSMKKKSPNLIGYNCSYRELKRLNRDYIVDAPVVLGEEVKFWNGYIVPPSVEGMRATCRNELAEDLQSDTFVLVQPPKTYAPLISWHRIPNVLLIGFDGISQINFRRNFPLVFNQLKMQDWFRMDGYTGIGENTQSNLMASLTGYSPHTLMNLKCDSSVIGCLKTVPLIWKHFKKKGFITAYGEGISNLFDSEKYGIFEGTIDFYARHKNLQSCIDRRFNIKHNYDYCEEFLKRHANTNRPFFGVFFGNGITNRSYDNARIQTELLDKVKKFKKMGILTQSIVVLFSYPVSSVKEKKTNFSQEDLPILYIWLPPWFKAFRPEIVQALRINSKRLTSPYDLHLTLQHLLELGERWPRAVDKLVDCPTCQTLFAPVPENRTCSDAGIGESQCPCDSYKLLSSNQMKQLSVGKQIVRSINEFLNHHNLHELCHNLTLKSVKMVLQRKDRKLSSGSTYRAYFSANPNNAEFSTTIRYANNRQELEYINVESINRLNNYQNDSSCMRRLRGRKFCICKSQILENHSTSEVTKLIPNKNKIDDKLYELPDMRENDQNIETLNIEVISV
Protein: Beta-hexosaminidase (EC 3.2.1.52) (A0A1D8PNR7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Ngs1p
- Chitinase 1
- Chitinase 3
- Chitinase 2
- Chitinase 4
- N-acetylglucosamine-6-phosphate deacetylase
- beta-mannosidase
- Glucosamine-6-phosphate isomerase
Sequence:
MVLDKMIIFHLLLWLCNVVVHAAKVEILPAPQSVTWENDTAIIINPRLLQANTSCPLLEDAFVRTVSAIEKSKWHPFPIDDFNTANGKNIKTSLVHIQVDDATVDLQLGVNESYTLKINTDGINIHAATTWGALHGLVSLQQLIIHTSEDKYVVPSSVTISDFPNFKHRGLMIDSGRNFLTVDSILEQIDIMALSKMNSLHWHLADSQSWPVALESYPHMIKDAYSNDEVYSKNDLKYIVDYARARGVRVIPEIDMPGHARAGWKQVDPTIVECADAFWTDAAVEPPPGQLNIESEKTYEVISNVYNELSDIFIDDVFHVGNDELQEKCYSAQLSPNNTVTDLLKRYLKKALPIFNKVNHRKLTMWDDVLLSDVSADKIPSNITLQVWHEISGVKNLTSRGYDVVVSSSDFLYLDCGNAGWVTNDPRYVETPENVDFNTGQGGSWCGPYKSYQRIYNFDFTANLTETEKNHVLGAEAALWSEQVDSTVLTTKIWPRTAALAELTWSGNKDSNGHHRGYEFTQRILNFREYLVKLGYGVSPLVPKYCLLNPHACDLYKNPPVY
Protein: Mini-agrin (Q5EBX5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVRPRLSFPAPLLPLLLLLAAAAPAVPGASGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDVVAQESLLDGGNKVVIGGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGIHFTAAPSMPPDVCRGMLCGFGAVCEPSVEDPGRASCVCKKNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCPPKSCDSQPCLHGGTCQDLDSGKGFSCSCTAGRAGTVCEKVQLPSVPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGESPSGTDGLNLDTKLYVGGLPEEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRAVVQSSGVGECGDHPCSPNPCHGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRGGAKCACPLGRSGSFCETVLENAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLARGPSGLLLYNGQKTDGKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPVPHTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQAVDNPCLNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETLAFDGRTYIEYLNAVTESEKALQSNHFELSLRTEATQGLVLWIGKVGERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQKLPVGQALPKAYGTGFVGCLRDVVVGHRQLHLLEDAVTKPELRPCPTL
Protein: Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (mDkk-3) (Q9QUN9)
Organism: Mus musculus (Mouse)
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
- Dickkopf-related protein 2
- Dickkopf-related protein 1
- Kremen protein 1
- Dickkopf-related protein 4
- Secreted frizzled-related protein 1
- Kremen protein 2
- Secreted frizzled-related protein 2
- Wnt inhibitory factor 1
- Secreted frizzled-related sequence protein 4
Sequence:
MQRLGGILLCTLLAAAVPTAPAPSPTVTWTPAEPGPALNYPQEEATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAAKTSSEVNLASLPPNYHNETSTETRVGNNTVHVHQEVHKITNNQSGQVVFSETVITSVGDEEGKRSHECIIDEDCGPTRYCQFSSFKYTCQPCRDQQMLCTRDSECCGDQLCAWGHCTQKATKGGNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPTSQLLDLITWELEPEGALDRCPCASGLLCQPHSHSLVYMCKPAFVGSHDHSEESQLPREAPDEYEDVGFIGEVRQELEDLERSLAQEMAFEGPAPVESLGGEEEI
Protein: Pyrethroid hydrolase Ces2e (EC 3.1.1.88) (Carboxylic ester hydrolase) (EC 3.1.1.-) (carboxylesterase 2E) (Q8BK48)
Organism: Mus musculus (Mouse)
Function: Carboxylesterase that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes trans-permethrin at a rate about 22-fold higher than cis-permethrin. Also hydrolyzes trans-cypermethrin. Hydrolyzes retinyl esters (By similarity).
Subcellular location: Microsome {ECO:0000269|PubMed:15123619}.
Interaction partners:
- Cytidine deaminase
- Beta-glucuronidase
- UDP-glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase 2A3
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase 2B17
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
Sequence:
MPLYKLLGWLNAVACGVLLLVLHVQGQDSASPIRNTHTGQVRGSLVHVKDTDIAVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLMGSEDLKMMNLILPPISMSEDCLYLNIYVPAHAHEGSNLPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVAIQYRLGVLGFFSTGDQHAKGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAVLPDLISSSSEMVHRIVANLSGCAAVNSETLMCCLRGKNEAEMLAINKVFKIIPGVVDGEFLPKHPQELMASKDFHPVPSIIGINNDEYGWILPTIMDPAQKIEEITRKTLPAVLKSTALKMMLPPECGDLLMEEYMGDTEDPETLQAQFREMKGDFMFVIPALQVAHFQRSHAPVYFYEFQHRPSFFKDFRPPYVKADHGDEIFLVFGYQFGNIKLPYTEEEEQLSRRIMKYWANFARHGNPNSEGLPYWPVMDHDEQYLQLDIQPSVGRALKARRLQFWTKTLPQKIQELKGSQERHKEL
Protein: Stress-associated endoplasmic reticulum protein 1 (Ribosome-attached membrane protein 4) (Q9Z1W5)
Organism: Mus musculus (Mouse)
Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9R2C1}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R2C1}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9R2C1}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R2C1}.
Interaction partners:
Sequence:
MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM
Protein: Transmembrane ascorbate-dependent reductase CYB561 (EC 7.2.1.-) (Cytochrome b-561) (Cytochrome b561) (P49447)
Organism: Homo sapiens (Human)
Function: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P10897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Note=Secretory vesicle containing catecholamines and amidated peptides. {ECO:0000250|UniProtKB:P10897}.
Interaction partners:
- Ferric-chelate reductase 1
- Peptidyl-glycine alpha-amidating monooxygenase
- Dopamine beta-hydroxylase
Sequence:
MEGGAAAATPTALPYYVAFSQLLGLTLVAMTGAWLGLYRGGIAWESDLQFNAHPLCMVIGLIFLQGNALLVYRVFRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALLFNLGGKYSAFEPEGVLANVLGLLLACFGGAVLYILTRADWKRPSQAEEQALSMDFKTLTEGDSPGSQ
Protein: Elongation factor G (EF-G) (Q2G0N1)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00054}.
Interaction partners:
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS17
Sequence:
MAREFSLEKTRNIGIMAHIDAGKTTTTERILYYTGRIHKIGETHEGASQMDWMEQEQDRGITITSAATTAAWEGHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKLGANFEYSVSTLHDRLQANAAPIQLPIGAEDEFEAIIDLVEMKCFKYTNDLGTEIEEIEIPEDHLDRAEEARASLIEAVAETSDELMEKYLGDEEISVSELKEAIRQATTNVEFYPVLCGTAFKNKGVQLMLDAVIDYLPSPLDVKPIIGHRASNPEEEVIAKADDSAEFAALAFKVMTDPYVGKLTFFRVYSGTMTSGSYVKNSTKGKRERVGRLLQMHANSRQEIDTVYSGDIAAAVGLKDTGTGDTLCGEKNDIILESMEFPEPVIHLSVEPKSKADQDKMTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMKKEFNVECNVGAPMVSYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFEFENAIVGGVVPREYIPSVEAGLKDAMENGVLAGYPLIDVKAKLYDGSYHDVDSSEMAFKIAASLALKEAAKKCDPVILEPMMKVTIEMPEEYMGDIMGDVTSRRGRVDGMEPRGNAQVVNAYVPLSEMFGYATSLRSNTQGRGTYTMYFDHYAEVPKSIAEDIIKKNKGE
Protein: Dynein light chain (Q84VW0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU365010}.
Interaction partners:
- Kinesin-like protein KIN-14P
- Kinesin-like protein KIN-14S
- Kinesin-like protein KIN-14K
- Kinesin-like protein KIN-14L
- Kinesin-like protein KIN-14J
- Kinesin-like protein KIN-14H
- Kinesin-like protein KIN-14O
- Kinesin-like protein KIN-14I
- Kinesin-like protein KIN-14Q
- Kinesin-like protein KIN-14R
Sequence:
MSDGRRKKSVNGGAPAQTILDDRRSSLPEVEASPPAGKRAVIKSADMKDDMQKEAIEIAISAFEKYSVEKDIAENIKKEFDKKHGATWHCIVGRNFGSYVTHETNHFVYFYLDQKAVLLFKSG
Protein: Cathelicidin 1 (Q49TP2)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MKMKVQVRSLILLAVAVLQVRSQNQTETRYEDIILVALPQLLPGEEQAFRPILNQLQVKTLNTEDVDQSEVSVRLTFPIQETFCSKSQGQPGKPCPLKKNGKLMMCSMKVRHPILEASNNLNTDLSTFVCEYMDAEDALQQKIRTRRSKVRICSRGKNCVSRPGVGSIIGRPGGGSLIGRPGGGSVIGRPGGGSPPGGGSFNDEFIRDHSDGNRFA