wanglab/gogpt-training-data huggingface dataset:
Protein: Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic (PHGPx) (EC 1.11.1.12) (P52032)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Glutathione reductase, chloroplastic
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase DHAR2
- Glutathione synthetase, chloroplastic
- L-ascorbate peroxidase 3
- Monodehydroascorbate reductase 3
- Glutathione S-transferase F6
- Peroxiredoxin Q, chloroplastic
- Glutathione S-transferase F9
- Glutathione S-transferase T1
Sequence:
MVSMTTSSSSYGTFSTVVNSSRPNSSATFLVPSLKFSTGISNFANLSNGFSLKSPINPGFLFKSRPFTVQARAAAEKTVHDFTVKDIDGKDVALNKFKGKVMLIVNVASRCGLTSSNYSELSHLYEKYKTQGFEILAFPCNQFGFQEPGSNSEIKQFACTRFKAEFPIFDKVDVNGPSTAPIYEFLKSNAGGFLGGLIKWNFEKFLIDKKGKVVERYPPTTSPFQIEKDIQKLLAA
Protein: Protein kinase domain-containing protein (Q9NAP8)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein kinase domain-containing protein
Sequence:
MDTMEQHQELEQEAIGPALPPPSAAQKSELFEEHNVEYELINGIPCYQPDHVVDGQVQIFERIGYDDKVGGTFLGLSADGKELVVRVAPIDALTHVVRAEAAFLCKVEAELQDWRLFSQVHKIFLTDDAWHMSLYFRGGPTLEQCFAMRNKFTLGTAGRLAEDVLNVIRCAHKHGYLVRNMDLNSFHYDAASRHLFMADISSLVKNISGDDGAPIASYAGCLDYAPCSDDGLVGARQDLETWFYQLVHLVLGELPWGSLSREEAGVKKAEFQKSKEFAELPEVFHKIAEVVIAKEYSVVEEEEYVKLAGLTEQIYKELGGVTDHEENMDFEREPTPDELPRFVACRADEIPTIAEEEEPAVEEENSE
Protein: Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) (Q9BQL6)
Organism: Homo sapiens (Human)
Function: Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.
Subcellular location: Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.
Interaction partners:
- Scaffold protein ILK
- Fermitin family homolog 3
- Filamin-binding LIM protein 1
- Pleckstrin-2
- Pleckstrin
- Fermitin family homolog 2
- Vinculin
Sequence:
MLSSTDFTFASWELVVRVDHPNEEQQKDVTLRVSGDLHVGGVMLKLVEQINISQDWSDFALWWEQKHCWLLKTHWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKILNIRRSEELSLLKPSGDYFKKKKKKDKNNKEPIIEDILNLESSPTASGSSVSPGLYSKTMTPIYDPINGTPASSTMTWFSDSPLTEQNCSILAFSQPPQSPEALADMYQPRSLVDKAKLNAGWLDSSRSLMEQGIQEDEQLLLRFKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDCTEEEMLIFAALQYHISKLSLSAETQDFAGESEVDEIEAALSNLEVTLEGGKADSLLEDITDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNKELEQGEPLEKLNLRGCEVVPDVNVAGRKFGIKLLIPVADGMNEMYLRCDHENQYAQWMAACMLASKGKTMADSSYQPEVLNILSFLRMKNRNSASQVASSLENMDMNPECFVSPRCAKRHKSKQLAARILEAHQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGIPVTTWRFTNIKQWNVNWETRQVVIEFDQNVFTAFTCLSADCKIVHEYIGGYIFLSTRSKDQNETLDEDLFHKLTGGQD
Protein: Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (p190) (P78357)
Organism: Homo sapiens (Human)
Function: Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:O54991}.
Interaction partners:
- Contactin-1
- Neurofascin
- Contactin-2
- Potassium voltage-gated channel subfamily A member 2
- Protein 4.1
- Receptor-type tyrosine-protein phosphatase zeta
- Band 4.1-like protein 5
- Potassium voltage-gated channel subfamily A member 1
- Myelin basic protein
- Nucleoredoxin
Sequence:
MMHLRLFCILLAAVSGAEGWGYYGCDEELVGPLYARSLGASSYYSLLTAPRFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLLYGDRVDSWTPFYQRGHNSTFFGNVNESAVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGLYGCPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETCHTPLYKESCEAYRLSGKTSGNFTIDPDGSGPLKPFVVYCDIRENRAWTVVRHDRLWTTRVTGSSMERPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSTSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSINITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDEGWVAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKAAHEYHPGSKPPLPTSGPAQVPTPTAAPNQAPASAPAPAPTPAPAPGPRDQNLPQILEESRSE
Protein: 5-methylcytosine G/T mismatch-specific DNA glycosylase (Q9I9F1)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKLRSQRALTERCRPAGRAAGGGAGGTAAPDGSRAAPRDLPVRDGGEGGARSSQQRHGTAVRCERPSARGGKAERCATKAEAGGRARRSSARSDAGSERGKRRRAARGDREAAGVQNEAPCEEAARVRHGQAVAELRAPPAAAGTQCVPAGQRPEPQPGAAADRLQGRPQSAAGGGERTGAGTAPAVLGEEESSGWKTGEETEPGDPGTRDSAADGDVSWPSDKKSFTAVQAPRGTEESAPRTQVDRRKTSPYFSSKYSKEALSPPRRKAFRKWTPPRSPFNLVQETLFHDPWKLLIATIFLNKTSGKMAIPVLWEFLRKYPSPEVARTADWKEMSELLRPLGLYALRAKTIIKFSDEYLNKQWKYPIELHGIGKYGNDSYRIFCVNEWKEVQPQDHKLNIYHAWLWENHEKLSVD
Protein: DNA translocase FtsK (P9WNA3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Located at the septum. {ECO:0000250}.
Interaction partners:
- Cell division protein FtsQ
- Cell division protein FtsZ
- Penicillin-binding protein PbpB
- Probable chromosome-partitioning protein ParB
- Probable peptidoglycan glycosyltransferase FtsW
- ESAT-6-like protein EsxU
- ESAT-6-like protein EsxB
- Tyrosine recombinase XerC
- ESAT-6-like protein EsxT
- Aconitate hydratase A
Sequence:
MSSKTVARSGTRTSRSKATSRGASRSARSAVPRKRSRPVKGVGRPSRRHHRSLLVSTGLACGRAMRAVWMMAAKGTGGAARSIGRARDIEPGHRRDGIALVLLGLAVVVAASSWFDAARPLGAWVDALLRTFIGSAVVMLPLVAAAVAVVLMRTSPNPDSRPRLILGASLIGLSFLGLCHLWAGSPEAPESRLRAAGFIGFAIGGPLSDGLTAWIAAPLLFIGALFGLLLLAGITIREVPDAMRAMFGTRLLPREYADDFEDFADFDGDDADTVEVARQDFSDGYYDEVPLCSDDGPPAWPSAEVPQDDTATIPEASAGRGSGRRGRRKDTQVLDRIVEGPYTLPSLDLLISGDPPKKRSAANTHMAGAIGEVLTQFKVDAAVTGCTRGPTVTRYEVELGPGVKVEKITALQRNIAYAVATESVRMLAPIPGKSAVGIEVPNTDREMVRLADVLTARETRRDHHPLVIGLGKDIEGDFISANLAKMPHLLVAGSTGSGKSSFVNSMLVSLLTRATPEEVRMILIDPKMVELTPYEGIPHLITPIITQPKKAAAALAWLVDEMEQRYQDMQASRVRHIDDFNDKVRSGAITAPLGSQREYRPYPYVVAIVDELADLMMTAPRDVEDAIVRITQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQAGAEKLIGMGDGLFLPMGASKPLRLQGAYVSDEEIHAVVTACKEQAEPEYTEGVTTAKPTAERTDVDPDIGDDMDVFLQAVELVVSSQFGSTSMLQRKLRVGFAKAGRLMDLMETRGIVGPSEGSKAREVLVKPDELAGTLAAIRGDGGE
Protein: Methylcobamide:CoM methyltransferase MtbA (EC 2.1.1.247) (MT2-A) (Methylcobamide:CoM methyltransferase II isozyme A) ([Methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M) (O30640)
Organism: Methanosarcina barkeri
Function: Methyltransferase involved in methanogenesis from methylamines methanol pathway. Catalyzes the transfer of the methyl group from the methylated corrinoid protein MtmC (MtmC1 or MtmC2) or MtbC to coenzyme M, forming the substrate for coenzyme-B sulfoethylthiotransferase.
Interaction partners:
Sequence:
MAEYTPKERLYRALRKQQVDRMPAVCFTQTATVEQMEACGAYWPEAHSDAEKMATLAEAAHTVVGFEAVRVPFDITAEAEFFGCGIKAGDLKQQPSVIKPSVKNLEDLEKLKNYNLKEGRIAVVLEAVKILSEKYGKELPIIGSMIGPFSLAQHINGDAWFGNLFTGEEVVPALLDFCSDFNVAYAKAMVENGADTIAIIDPTASYELIGGEFYEKYALPYQKKIVDAMKELDVATVLHICGNTTNGLGIMDKTGVNGISVDQKVDIKTATGSVKNAIIVGNLDPVAVLWNGTPEEIAEASKKALDAGVGLLTVGCGTVSMTPTVNLQKMIECAKSHTY
Protein: C-C motif chemokine receptor 4 (G3V7C3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- C-C motif chemokine
- C-C motif chemokine
- C-C motif chemokine 5
- Guanine nucleotide-binding protein G
- C-C motif chemokine ligand 27
- Stromal cell-derived factor 1
- C-C motif chemokine 2
- C-C motif chemokine ligand 9
- C-C motif chemokine 6
- C-C motif chemokine 3
Sequence:
MNATDVTDTTQDEAAYNSYYFDESLPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIISWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLRARTLTYGVITSLITWSVAVFASLPGLLFSTCDTENNHTYCKTQYSVNSTTWKVLSSLEINVLGLVIPLGIMLFCYSMIIRTLRHCKNEKKNRAVRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYIAQLFRTCRGPLVLCQHCDFLQISSADTSSSSYTQSTVDHDFRDAL
Protein: Protein P9 (Protein IX) (Q9XJR9)
Organism: Pseudoalteromonas phage PM2 (Bacteriophage PM2)
Subcellular location: Virion membrane {ECO:0000305|PubMed:12134022}. Note=Part of the capsid inner membrane. {ECO:0000305}.
Interaction partners:
Sequence:
MRTTTKKQIERTDPTLPNVHHLVVGATGSGKSAFIRDQVDFKGARVLAWDVDEDYRLPRVRSIKQFEKLVKKSGFGAIRCALTVEPTEENFERFCQLVFAISHAGAPMVVIVEELADVARIGKASPHWGQLSRKGRKYGVQLYVATQSPQEIDKTIVRQCNFKFCGALNSASAWRSMADNLDLSTREIKQLENIPKKQVQYWLKDGTRPTEKKTLTFK
Protein: Heat shock 70 kDa protein 17 (Heat shock protein 70-17) (AtHsp70-17) (F4JMJ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Heat shock 70 kDa protein BIP1
- Heat shock 70 kDa protein BIP3
- Heat shock 70 kDa protein BIP2
- Endoplasmin homolog
- ARM repeat superfamily protein
- Fes1B
- Fes1A
- Fes1C
- Chaperone protein dnaJ 20, chloroplastic
- Chaperone protein dnaJ 3
Sequence:
MGKIFSWLVVLLSLISLVPVPSESAVLSVDLGSEWVKVAVVNLKRGQSPISVAINEMSKRKSPALVAFQSGDRLLGEEAAGITARYPNKVYSQLRDMVGKPFKHVKDFIDSVYLPFDIVEDSRGAVGIKIDDGSTVYSVEELLAMILGYASNLAEFHAKIPVKDMVVSVPPYFGQAERRGLIQASQLAGVNVLSLVNEHSGAALQYGIDKDFANGSRHVIFYDMGSSSTYAALVYYSAYSEKEYGKTVSVNQFQVKDVRWDLGLGGQSMEMRLVEHFADEFNKQLGNGVDVRKFPKAMAKLKKQVKRTKEILSANTAAPISVESLHDDRDFRSTITREKFEELCKDLWERSLTPLKDVLKHSGLKIDDISAVELIGGATRVPKLQSTIQEFIGKQQLDKHLDADEAIVLGSALHAANLSDGIKLKRRLGIVDGSPYGFLVELEGPNVKKDESTKQQLVPRMKKLPSKMFRSFVLDKDFDVSLAYESEGILPPGTTSPVFAQYSVSGLADASEKYSSRNLSAPIKANLHFSLSRSGILSLDRGDAVIEITEWVDVPKKNVTIDSNTTTSTGNATDENSQENKEDLQTDAENSTASNTTAEEPAVASLGTEKKLKKRTFRIPLKVVEKTVGPGAPFSKESLAEAKIKLEALDKKDRERRRTAELKNNLESYIYATKEKLETPEFEKISTQEERKAFVEKLDEVQDWLYMDGEDANATEFEKRLDSLKAIGSPISFRSEELTARPVAIEYARKYLTELKEIIKEWETNKTWLPKEKIDEVSKEAEKVKSWLDKNVAEQEKTSLWSKPVFTSTEVYAKVFTLQDKVTKVNKIPKPKPKIEKVTKTENTTKEEEQSKSSDEAAKEEESHDEL
Protein: ASW (Histidine triad nucleotide binding protein W) (Wpkci) (Q9I870)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MAGGIVRSPAAWRGGAALLGKVARQEFSANVIREEEPLWTRSALRSMIFHRKLLRFFLAAPQKAVVGLSGAEDCGAPLLGRLMIVGEKCAASLGLTDGFRMAVRYPPSVPSDYRARLCILGGRQLGQPPG
Protein: MIPC synthase subunit (SurA), putative (Q4WDG6)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MRRGVLIFLIVNLLIISFLVRSVFTLLSLLVEDASADAIRHAELPSPNSSLIEQRPQIIPKIIHQTYKNETIPEVWREAQQSCKDLHPDYEYILWTNEKSREFIKNEYPWFLDTFDGYKYPIQRADTIRYFVLAHFGGTYIDLDDGCNRRLDPLLSYPAWVRRTVPTGISNDAMGSVPQHPFFLRVIELLKSYDRSWLLPYITVMYSTGPLFLSVIWKEYMQDKPSEAARVRILMQDEYNKYSWSFFTHHVGNSWHGKDARLIFWMGQHWMFLTVLGFILASVVGFCLWWVYGRMILLSSKYRYRYSKLPGLGRLSSPTRRSRGVMPTLLRRVSFKEDEESAHVTETSFELYSRRD
Protein: Magnesium chelatase subunit I (B2CPV1)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
FGDPYNSDPEDPESMGIEVREKVVNGEELTITMTKINMVDLPLGATEDRVCGTIDIEKALTEGVKAFEPGLLAKANRGILYVDEVNLLDDHLVDVLLDSAASGWNTVEREGISISHPARFILIGSGNPEEGELRPQLLDRFGMHAQVGTVRDAELRVKIVEERARFD
Protein: Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) (Q8NHM5)
Organism: Homo sapiens (Human)
Function: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:17994099}. Nucleus {ECO:0000269|PubMed:26237645}. Chromosome {ECO:0000269|PubMed:26237645}.
Interaction partners:
- S-phase kinase-associated protein 1
- E3 ubiquitin-protein ligase RING2
- RING1 and YY1-binding protein
- Polycomb group RING finger protein 1
- E3 ubiquitin-protein ligase RING1
- YY1-associated factor 2
- BCL-6 corepressor-like protein 1
- BCL-6 corepressor
- Chromobox protein homolog 8
- Histone-lysine N-methyltransferase EZH2
Sequence:
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS
Protein: FHA domain-containing protein FHA1 (Protein FORKHEAD-ASSOCIATED DOMAIN 1) (AtFHA1) (Q9SFV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in the control of plant organ development (By similarity). Does not show transactivation activity in yeast.
Subcellular location: Nucleus {ECO:0000269|PubMed:23192389, ECO:0000269|Ref.3}. Note=Detected at discrete loci in the nucleus. {ECO:0000269|PubMed:23192389}.
Interaction partners:
- FHA domain-containing protein At4g14490
- Insulin-induced protein
- Cryptochrome-2
- Cryptochrome-1
- Histone H4
Sequence:
MATAVGSGSDVEVGFAKLQGEDFEYYMQSYSIILGRNSKKSTVDVDLSSLGGGMNISRNHARIFYDFTRRRFSLEVLGKNGCFVEGVLHLPGNPNVKLDSQDLLQIGDKEFYFLLPVWSILGGPLGPRHHVLGKATVVPYHNYHSGPGSGSGKNGVRSRELYEYDDEDDDEEEDIRGSGKKTWRDGHEGVYASGEKKREGRSKADREADDQQFLQLMHGSGWSVTDIKGVWKRMASQSSKKIPITRRLGYP
Protein: Lipoprotein MALP-404 (Macrophage activating lipoprotein-404) (Q9R3N6)
Organism: Mycoplasmopsis fermentans (Mycoplasma fermentans)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}.
Interaction partners:
Sequence:
MKKSKKILLGLSPIAAVLPAVAVSCGNNDESNISFKEKDISKYTTTNANGKQVVKNAELLKLKPVLITDEGKIDDKSFNQSAFEALKAINKQTGIEINSVEPSSNFESAYNSALSAGHKIWVLNGFKHQQSIKQYIDAHREELERNQIKIIGIDFDIETEYKWFYSLQFNIKESAFTTGYAIASWLSEQDESKRVVASFGVGAFPGVTTFNEGFAKGILYYNQKHKSSKIYHTSPVKLDSGFTAGEKMNTVINNVLSSTPADVKYNPHVILSVAGPATFETVRLANKGQYVIGVDSDQGMIQDKDRILTSVLKHIKQAVYETLLDLILEKEEGYKPYVVKDKKADKKWSHFGTQKEKWIGVAENHFSNTEEQAKINNKIKEAIKMFKELPEDFVKYINSDKALKDGNKIDNVSERLEAIISAINKAAK
Protein: Mediator of RNA polymerase II transcription subunit 25 (A0A3Q7JC00)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Plays a positive role in wound-induced activation of jasmonate-responsive genes whose promoters are targeted by MYC2.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 21
Sequence:
MVDKLIVAVEGTAVLGPYWKIIVSDYLDKIIRCFFGVDSTSQKSSAADVEVSMVMFNTHGPYSACLVQRSGWTKDMDTFLQWLSAIPFSGGGFNDAAVAEGLAEALVMFSVPNGNQTQQKMEGKKHCILISGSNPYPLPTPVYRPQMQKLEQNENIEAQTDSRLADAETVAKTFPQCSISLSVICPKKLPKLRAIYDAGKHNPRAADPPIDTAKNPNFLVLISENFIEARAAFSRSGLTNLASNHSPVKMDVSSVLPVSGTQSISNSAANVSVISRPPISAGNIPPATVKIEPNTVTPMTGPGFSHIPSVRPALQPVPSLQASSPLSVSQEMVSHTENVQEMKPIVSGMTQSLRPVAAAAANVKILNGVAQAHQVLGGGTSIGLQSMGGTPMLSSMISSGMASSVPASQAVLSSGQSGVTTMTGAVPLAGSAQNTQNSAPSSFTSTAPSMSGQTVPAMSQGNIPGTQMMPSGTGMNQNMLTGLGATGLPSGTGTMMPTPGMSQQGQPGMQPVGVNSTSANMPLSQQQTSGALPSAQSKYVKVWEGNLSGQRQGQPVFITRLEGYRSASASESLAANWPPTMQIVRLISQDHMNNKQYVGKADFLVFRAMNQHGFLSQLQEKKLCAVIQLPSQTLLLSVSDKACRLIGMLFPGDMVVFKPQIPSQQQQQQQQQQLQAQHPQLQQQQQQQQQHLTQLQQQPLQQLQQQQQQQPLMQLQQQQQIPLQQSQVPQMQQQQIHQMQQQQQIPQMQQQQQIPQMQQQQQQQPMVGTGMNQTYMQGPARSQLMSQSQGSSQGLPITPGGGFMN
Protein: BTB and MATH domain-containing protein 40 (Q9NF14)
Organism: Caenorhabditis elegans
Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Interaction partners:
- Cullin-3
- AB hydrolase-1 domain-containing protein
- Uncharacterized protein
- Serine/threonine-protein kinase RIO2
- DUF1014-domain-containing protein
- Uncharacterized protein
- ANK_REP_REGION domain-containing protein
Sequence:
MSDRHLYGSDHSYLSSKPSCSSCRRQSSTSQKNECMTNPGSIVLTQRWTVCNFESLLKLSRPGSCLRSTVFKDDAVPDACWQLCLYPGGKREENANNVSLFLKMSATSPSKEVVLKAEYRFYFLDDNDEPKFSNVNVGEFHAKPPKGGHSWGLRNIPTQKVQNSIRQDKSLVISCHIELIPDASKVPCKRVPITPSIEMPFAQIPRAHVESELEMLASGDGTDMTIVAGPLDGEREQFRVHAYKLRAHSDVFQMMLSHTEMRENQEKRIEILDFSPTSVRAMVEFIYAGVIKSDIDVYQAVDVMQIAEKYQILALKMTCEQHLLDRLNVNNVLECITHAERYNTDVLYDACVDFAIHNRQHVMALTSWRNFISDEPVLASNLLEKMVKSNDNSSPPVKKPRV
Protein: PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac domain-related protein 5) (PiggyBac transposase 5) (Q8N414)
Organism: Homo sapiens (Human)
Function: Transposase that mediates sequence-specific genomic rearrangements. Can induce genomic rearrangements that inactivate the HPRT1 gene.
Subcellular location: Nucleus {ECO:0000269|PubMed:24180413}.
Interaction partners:
- DNA transposase THAP9
Sequence:
MAEGGGGARRRAPALLEAARARYESLHISDDVFGESGPDSGGNPFYSTSAASRSSSAASSDDEREPPGPPGAAPPPPRAPDAQEPEEDEAGAGWSAALRDRPPPRFEDTGGPTRKMPPSASAVDFFQLFVPDNVLKNMVVQTNMYAKKFQERFGSDGAWVEVTLTEMKAFLGYMISTSISHCESVLSIWSGGFYSNRSLALVMSQARFEKILKYFHVVAFRSSQTTHGLYKVQPFLDSLQNSFDSAFRPSQTQVLHEPLIDEDPVFIATCTERELRKRKKRKFSLWVRQCSSTGFIIQIYVHLKEGGGPDGLDALKNKPQLHSMVARSLCRNAAGKNYIIFTGPSITSLTLFEEFEKQGIYCCGLLRARKSDCTGLPLSMLTNPATPPARGQYQIKMKGNMSLICWYNKGHFRFLTNAYSPVQQGVIIKRKSGEIPCPLAVEAFAAHLSYICRYDDKYSKYFISHKPNKTWQQVFWFAISIAINNAYILYKMSDAYHVKRYSRAQFGERLVRELLGLEDASPTH
Protein: Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) (P54116)
Organism: Mus musculus (Mouse)
Function: Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P27105}; Peripheral membrane protein {ECO:0000250|UniProtKB:P27105}; Cytoplasmic side {ECO:0000250|UniProtKB:P27105}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P27105}. Cell membrane {ECO:0000250|UniProtKB:P27105}; Lipid-anchor {ECO:0000250|UniProtKB:P27105}; Cytoplasmic side {ECO:0000250|UniProtKB:P27105}. Membrane raft {ECO:0000250|UniProtKB:P27105}. Melanosome {ECO:0000250|UniProtKB:P27105}. Cytoplasmic vesicle {ECO:0000269|PubMed:10383825}. Note=Localizes to juxtanuclear structure probably derived from the Golgi apparatus. Colocalizes with cortical actin microfilaments at small plasma membrane protrusions. Associates with alpha-granular lipid rafts. Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:P27105}.
Interaction partners:
- Prohibitin 1
- Flotillin-1
- Acid-sensing ion channel 3
- Band 3 anion transport protein
- Flotillin-2
- Acid-sensing ion channel 1
- Prohibitin-2
Sequence:
MSDKRQSSHVQSQRIPESFRENSKTELGACGWILVAASFFFVIITFPISIWICIKIVKEYERVIIFRLGRILQGGAKGPGLFFILPCTDSLIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQLQRAMAAEAEAAREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPVDMLQGIMGSNH
Protein: WASH complex subunit 2C (A0A0A0MT65)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMNRTTPDQELVPASEPVWERPWSVEEIRRSSQSWSLAADAGRVYDEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDNEQNQHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAMGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSD
Protein: Putative caspase recruitment domain-containing protein 17P (Caspase-1 inhibitor INCA) (Inhibitory caspase recruitment domain protein) (Q5XLA6)
Organism: Homo sapiens (Human)
Function: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Caspase-1
- Caspase recruitment domain-containing protein 18
- Caspase recruitment domain-containing protein 16
Sequence:
MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDSVIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS