wanglab/gogpt-training-data huggingface dataset:
Protein: WW domain-containing protein (Q383B5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGEPGVVIPKVGERFVGEDGSVSVVLADTVDEDYVPTQEEIEGFAEWMGMNLPEDNEFLHIAVEGLKAPLPKNWRPCRTEDDEVYYFNFKTGESTWCHPMDEVHRERFRKAKEQKQNLGVGGTTSRDRSANIVSGTSTTAQRGAMGNAVGSALATPTNLQGGRLEKLSPALGTKYAPLRSPPLSGGATTSSFLSSNITTGGTAAGGPLDRGSESGGTGGGKRRFVSETEEALEKRIRQEREEAFLEEQKKAEATIQERRMNMQRSHEEEVKKLRAETEAKLAELRANRPNNGAEAVKKKEMEALWTERLDEVKREGEGLEKKLASLREENEQRIAAEVKKIEAKASADLEAKVKRIEADGAAALEKAKREAQAALSAKKNELQKKAREELEKLKKEVEKQHSDDMAALERKFSSDGHQSQVKSAASTAAPSHATDVESRIAAIREKEKQEVSAIQKRSEEEKAALRRSMDEAIGALRREIHDIQQAAASEAVPAARNSGPSSVELEEVRRRWRAEEARRMQLLAEDRRAKVLAQEKSLETSSSLPKSSAAQEVTADQSLKMRAILTAKEKEHQETEALLRSTLQEELTRTSLSLDAQLEAAVADAFKVFVRSTEVSRRFEKEDFERRRASNSVAQVAKEGKGMDSKPKVSEGASFDAEELLQKKVEEAVGEALQNMRADHENALRRLRQRYEEERRMLIASVDEEVSTMEEKERQQIDQKLKGQTRDYEPGAGNATTRTAGGTSTSIGVPLGLLQQRLTSIEAAYSNQIQDLEADLMSLNSAIRMMDELPNFLGQRASKNQETDFTRCGSHMEPGNSFRYVPSTGKHALPTGKGGASPSTMFSSEARLFLAGQFRDFSARRDALQAAREEWYANAMEAAAPVPAVGSGPLADTAGLSDVHTHMISLIGSLGGRLERIMRRVNALQAYTEGKRLSPPRQRRRMRHGSAARHDKKTKSTHKKHRHAKAPTGHPHGSLIQKWSRILSELSSPPVTGGELSAFLRHLGRD
Protein: Cyclic dipeptide prenyltransferase (CdpNPT) (EC 2.5.1.-) (Tryptophan aminopeptidase CdpNPT) (EC 3.4.11.17) (Q4WB07)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Prenyltransferase that catalyzes reverse prenylation at position N-1 of tryptophan-containing cyclic dipeptides. Accepts only dimethylallyl diphosphate (DMAPP) as the prenyl donor but shows broad substrate specificities toward its aromatic substrates. Shows also tryptophan aminopeptidase activity with preference for linear peptides containing a tryptophanyl moiety at the N-terminus.
Interaction partners:
Sequence:
MDGEMTASPPDISACDTSAVDEQTGQSGQSQAPIPKDIAYHTLTKALLFPDIDQYQHWHHVAPMLAKMLVDGKYSIHQQYEYLCLFAQLVAPVLGPYPSPGRDVYRCTLGGNMTVELSQNFQRSGSTTRIAFEPVRYQASVGHDRFNRTSVNAFFSQLQLLVKSVNIELHHLLSEHLTLTAKDERNLNEEQLTKYLTNFQVKTQYVVALDLRKTGIVAKEYFFPGIKCAATGQTGSNACFGAIRAVDKDGHLDSLCQLIEAHFQQSKIDAAFLCCDLVDPAHTRFKVYIADPLVTLARAEEHWTLGGRLTDEDTAVGLEIIRGLWSELGIIQGPLEPSAMMEKGLLPIMLNYEMKAGQRLPKPKLYMPLTGIPETKIARIMTAFFQRHDMPEQAEVFMENLQAYYEGKNLEEATRYQAWLSFAYTKEKGPYLSIYYFWPE
Protein: Probable acyl carrier protein PigG (Peptidyl carrier protein) (PCP) (Q5W265)
Organism: Serratia sp. (strain ATCC 39006) (Prodigiosinella confusarubida)
Function: Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Carrier of the L-prolyl group transferred from L-prolyl-AMP by PigI.
Interaction partners:
- NADH-quinone oxidoreductase subunit C/D
- Non-ribosomal peptide synthetase
- L-proline--[L-prolyl-carrier protein] ligase
- Non-ribosomal peptide synthetase
- Non-ribosomal peptide synthetase
- Pyruvate-flavodoxin oxidoreductase
- isochorismatase
- Beta-ketoacyl synthase PigJ
- 4-hydroxy-2,2'-bipyrrole-5-methanol synthase PigH
- S-adenosyl-L-methionine-dependent methyl transferase PigF
Sequence:
MLESKLINHIATQFLDGEKDGLDSQTPLFELNIVDSAAIFDLVDFLRQESKVSIGMQEIHPANFATVQSMVALVQRLKAHPEQGGAA
Protein: dihydropyrimidinase (EC 3.5.2.2) (Q9VND9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTSPKPVKKVPIHLQSAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLAK
Protein: TIA1 cytotoxic granule-associated RNA binding protein (A0A8I6AS00)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVSQSSPGNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFIRQTQSSAPWMGPNYSVPPPQGQNGGMLPNQPAGYRVAGYETQ
Protein: Cytoplasmic envelopment protein 2 (F5HAC7)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating (By similarity). Additionally, antagonizes the viral DNA-triggered antiviral immune response by targeting host STING1 and preventing its dimerization and trafficking.
Subcellular location: Virion tegument {ECO:0000255|HAMAP-Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
Interaction partners:
Sequence:
MAWRSGLCETDSRTLKQFLQEECMWKLVGKSRKHREYRAVACRSTIFSPEDDGSCILCQLLLFYRDGEWILCLCCNGRYQGHYGVGHVHRRRRRICHLPTLYQLSFGGPLGPASIDFLPSFSQVTSSMTCDGITPDVIYEVCMLVPQDEAKRILVKGHGAMDLTCQKAVTLGGAGAWLLPRPEGYTLFFYILCYDLFTSCGNRCDIPSMTRLMAAATACGQAGCSFCTDHEGHVDPTGNYVGCTPDMGRCLCYVPCGPMTQSLIHNEEPATFFCESDDAKYLCAVGSKTAAQVTLGDGLDYHIGVKDSEGRWLPVKTDVWDLVKVEEPVSRMIVCSCPVLKNLVH
Protein: SUZ domain-containing protein (B2D6L4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSKENVSLVVADSWDDADADPVKELMDKVEKVKLLQRKEEKKEAFFEKVKAEESSGVVSKLQTEEGLGPSAEEPKRVFLRRPKDGFAASENVIEASPPTSADTEEQPVTNVRSRSHHKLNQKEKQPAPTYEERQAAYQAARNRILGTEYKPDNQEIKEIKFIDRSKSPETLKMTQQNMVEHYGEELSRELMEQPAEIVPPERQYTPDFTLQQPPPSVSESGGVYNGPPGFQQKQPNFQPTLQQQSLHQQQYLDNQYMMQMNVQIPIQYHNQTQHQFVPHEASAISTTSQNSNGDGQNDQAIYYYQAPTQQPMNYIPYNLPNMAYPPPNFQPQGQLHHQMNAGQLHQIQQQQQQCQQIQHQPPQQHQQVINGQVMNQQNQRNQVNSYPQQNGAGRGQNRQPMMYQMPCNSGPTAKPPPLMNQMQNRCMTNNGQNYQNRNMQQQGQQRSYSSQPQNGQFYQNGNSNQNNPNNGRKQQHQPQQQQNKSGKFGQNRNDMQKNNYQPNLQQPPMSQNPIPFGCPPRNVNAIREQHANNGSPNTGAGILGPHPMMSASQWPALQQNRPQ
Protein: Mud protein (Q9NCW7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDTRSWRKVLLQWIGECHFIESNYITLEQSDLDSFFSVFIQKIQETENVKGKNELQDQPTEQSPLVQEFLAHNYPEFIAQQDDKEVDLPLDCLYVYTLLLHYSCVKKPSLFFHNICNKLPELTQTCIASFFRETVDRLLTREYLSQAIANVAVVYRQGVSTSVSPCLPSSSLSPDSRSDDAPCPSTPSSSSSQPSSSTPQLRNHREQLRLNGCEMPPPSTPKTELLEQRTKELRGIRTQLEVVRYEKALLEEQQMEKDELIKVLNKEKMMAKMELEKLRNVKLTEEHHDNESHHIMPYEFEHMKGCLLKEIGLKESLIAEITDKLHDLRVENSELSEKLNLAGKRLLEYTDRIRFLESRVDDLTRIVSSRDVMISSLESDKQELDKCLKEARDDLHNRIEVLNASSDLLDCSLSPNTTPENLASSVIDKQLREKEHENAELKEKLLNLNNSQRELCQALSSFLQKHNIDHEFPVEWTSSSLLSTISAIESKFVNTLEKSTQMKKECDVQSVCVEKLLEKCKLLSVSLGCQPKELDGFEATIPEAMESGFESSRECEPILSCCHMKVVDIASKNNDLELDNERLNDKCAELKSIIDRGDQHLADINLQLIEKEKQIKDVGAEIQELRKRNINLENMLSQIADKEASAASHAQHLKQCGELLRAKYEVCRNELIAKNAAQDELVRMMMVPDGETLNGRVRQLIDLEMMHDEHNKMYAQMLRQLNELSAKHDNMTHSHLDFVKRTEIELETKNAQIMAFDEHNNHFDRFLTRIFTLLRSRNCPKSTTMGSATNFLESMHIEKRFENIEMLIEGQLLSADDLKRELDDLRSKNEELAKQNINGIIKRNKFITSLEVNTEKVKQYITDLEEEAFKRKQKVVQLENTLSKEQSNAKEMAQRLDIAQQEIKDYHVEAIRFINTIRDRLQQDFNGVNTPQQLGTCMTEFLKMYDQMEVRYEESSSLVEKLTESQAKLEMQVAELQVELENKDTNQHSGALIKQLNDTIQNLEKVNAKLSEDNTVSHTVHSKLNESLLKAQKELDLRAKIIENLEASERNLSMKLCELKDLKNKLKSSDEKIAQIKETYEEQIKALQAKCDMEAKKNEHLERNQNQSLTQLKEDALENCVLMSTKLEELQAKLQEGQQLVDSQKLELDMNRKELALVKSAYEAQTKLSDDLQRQKESGQQLVDNLKVELEKERKELAHVNSAIGAQTKLSDDLECQKESGQQLVDNLKVELEKERKELAQVKSVIEAQTKLSDDLQREKESAQQLVDNLKVELDKERKELAQVNSAFEAQTKLSDDLQRQKESAQQLVDNLKVELEKERKELAKVNSAFEAQTKLSDDLQLEKDLAQQLVDTLKVELDKERKELAQVNSPFEAQTKLSDDLQRQKESAQQLVDNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLEMELDKERKELAQVKSAIGAQTKLSDDLECQKESVQQLVDNLKVELEKERKELAKVNSAFEAQTKLSDDLKLQKEDAQREVFLVKERLVKEKREFEVKLATLEDIIETLEMRCTQMEEERATAYEQINKLENRCQEKDNVKSSQLQVETFKVECLHHQLKSEMATHNSLVEDLNRKLAEKVSKLDFVQSRLMTEIAEHNQVKDQLAQITDIPKVVELQHRLEAETAEREEAQNKLAVVTGRLDEITRELDNARLEHGAQILRMEETAREVGNKNAELCELIEFYRNRVEALERLLLASNQELEELNSIQSNQAEGVRDLGDTYSAAEGRQTESDQDKERYQKLALDCKILQAKYRDAKDEIKRCEKKIKDQRLEMEGKLEKMKNKMRSLYTAEVTRMKEKQERDAAKSASELEALTAQNAKYEEHTRKLSNQIVRLNEKILEQQKQHAIISTNLRHLQMQPISETKPSSTTLTVSSSSSAPNDDWQPFKRPNVPSSNLAMEDEEGEVFNNTYLTDLKLGRVPADMTAEELIYRNSLQPPHLKSTYAAQYDLGSQDEDLKDGPHSLDDSMSALLSSSSTGTRKKSMGTHYKRPGPPTPSKNGGRLSFGSSEPPREILREFGDHNNTSKTPARFKFLTQRFSVGSSGLPRDELPRRKRPNLLTGIHRRRLRHAVDIFCTSTPRKSRSYYDQQRMIGASDADKSEAVETEDEVIEVEPDAVPELEPLEDADQQGTPHLSTAALLALTKGNTRRLTGTTKSKKGRVSLSLHGNIFAKSRPASFVAGKRVQLRRKLRRDRIMGRFDEARHLDQMRLSHSAQAAKSPENNNYSLHNRNEEEHLPSENNVMGKTVVLVGKRRLSPVVSTTFNVEERSETSLLQQQFEHENCVTWAMHGGESVMMEETQNDWYFEQLCKETESTAPFQLQPLDYKPLDEEQVEPKFTQLVAASCSNITTTSCATNMTGASSCTVYSIGSVHMQPLPQINITYVQQPSDLQQRRPTRHRSLMAQCRRFLRHLSLGQRLVMGFALLVMVGLSLHLADKLVLVITGILSGMGLVFLTYSCPGRN
Protein: Putative P2Y purinoceptor 10 (P2Y10) (P2Y-like receptor) (O00398)
Organism: Homo sapiens (Human)
Function: Putative receptor for purines coupled to G-proteins.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MANLDKYTETFKMGSNSTSTAEIYCNVTNVKFQYSLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSKESGSSMIG
Protein: Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) (Q9P244)
Organism: Homo sapiens (Human)
Function: Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Postsynaptic density membrane {ECO:0000250}. Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane. {ECO:0000250}.
Interaction partners:
- Disks large homolog 4
- Receptor-type tyrosine-protein phosphatase delta
- Disks large homolog 1
- Receptor-type tyrosine-protein phosphatase S
Sequence:
MAPGPFSSALLSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGANDSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYKVYGDGDSRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALPAQDHYEALREVESQAAPAVAVEAKAMEAETASAEPEVVLGRSLGGSATSLCLLPSEETSGEESRAAVGPRRSRSGALEPPTSAPPTLALVPGGAAARPRPQQRYSFDGDYGALFQSHSYPRRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARACLAFTSTEWMLESTV
Protein: Cholinergic receptor nicotinic delta subunit (C9JJV8)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDA
Protein: START domain-containing protein (Q20442)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MQNGHRSMKPRVQSMNILSIPLEPEFKSLPQNVPENIPVLRRRKYTKQQRKSLVIEPDISLILAAGQNQSSSSDDDDTKVQIDSNTLPQNRRKYAGRRNMKKRFYSTSNLKGNEDENDENSSKQIGTKSLSVRDLNGDNIDFNNRDSVKKWTSQIFAELESIPSSRRGSMEVTRAMTNPPPELMINLAPTLAPPSPMKRKRFPVFDEQEAGFQPIAPVPSPRRQQEDVVGPTFLRDLLTASCSRSPCSESNYSDRLATSDTATTQKASRASSFEWLENSGHGKYEQCSSDEADREVASIEMVKQTEVLQRKKTIEDLEESVNELQSLGNGSWFPHPPPPPAEARDQIYESLPASFRNRKSENRKNAVGSVYDNAAISSKPSSSETTSFSQQKPIIDRKPFSLENLPMVQRLTELSAAKKNADSKNEVAKRSNTFSLQLAERDAVDACSWLRKAGFSKYADQFEEGKLPIVASKDPTLLEADLRALNRRIDVLNRCHTMKVDSVPMRRRINNEFPRLDPMKIDDNSGYSSDSWRYGSVGGSHHSNTWSRPSGSDHHVYGGSLARMPNSTSSAWHHQMADPTRDSRKVLRTDWYDAQNTPPRGRNNDVLETASSAACVNELNSKLQRSQSERIKDRARAIMKKMDLRSTNKRPKETRGRPAPMNIGDPVLVSYDTPKNSIRSHHIDRPSILPEIKTALPRHHNILTTVKPENLKVNTEKIDIISSSDEPIGRTALTKRSDSGLGSSLSRSPSGPHTQRIRQSLLPYSNATSSSASAYSCCSWGSSTKLLDEQQPFFTDMVELARSIDSLNLIEMTRLRKTAFLRLSSILERNIEGKGVGLVDPDQEELPSKHVWSVQRLIKRMKINDGQKREKDVDGDGAVFGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNTDVFVGENLLDSTQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQLGASRLDKVTPGNRRHKTVGATGLPSEKEMKEARACQLCLTMLIEYVQTVFMVPDGLDDSMDAEDDNPNLTELGLKGPRSFLVDRVIDLIRDHSDQWKNWTIEGSFRGIEISSKRPSDSHPLKTFRVWLNVPAGPKSVMMRLLKERYTWDSSVINWRHLEYVSAPDTDIHQYVVNETIGHPTKDCHVARFHSSGLTEIRGACAIAERSVKCTEDQLLGGVSATIFDQRFLIEPVSGGQSRVNYIARVDLKGRSLQWYNKSFGSIMCRHLDRLRESFHLGDKGGPETNV
Protein: MLP-like protein 43 (Q9SSK5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable inactive purple acid phosphatase 29
Sequence:
MAEASSLVGKLETEVEIKASAKKFHHMFTERPHHVSKATPDKIHGCELHEGDWGKVGSIVIWKYVHDGKLTVGKNKIEAVDPEKNLITFKVLEGDLMNEYKSFAFTLQVTPKQGESGSIAHWHLEYEKISEEVAHPETLLQFCVEISKEIDEHLLAEE
Protein: Probable eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 30 kDa subunit) (eIF-3 30 kDa) (P87128)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit C
Sequence:
MDSWEDFLVEDPAKPAEFDFPLGKDSQSSSKPKKRFDDEEDEDEEENKESLQNDSHSVSQKSSSSSQNDQGSNKMTRIQQKIQERNFEKAIKASEAAAKEESLESSKEAMRQAEIDSDLANAMDLFDIVDKNSASANRSKQADQRQLKTKADYAAFQADILKKVKNCQTTAEYNNFVQDLIPLLLTGLNATNLKAVQKSVNKLVVNKEQQEKTQSKRGAAAPAAKPVSTAAPSKKGGKPTVNVNSKKTVADKSAYEDYIEDEYDDYADDFDDFM
Protein: Protein transport protein SEC23 F (AtSEC23F) (Protein transport protein SEC23 B) (AtSEC23B) (Protein transport protein SEC23 D) (Q8VXX0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:P15303}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15303}; Cytoplasmic side {ECO:0000250|UniProtKB:P15303}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P15303}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15303}; Cytoplasmic side {ECO:0000250|UniProtKB:P15303}. Membrane {ECO:0000250|UniProtKB:P15303}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15303}; Cytoplasmic side {ECO:0000250|UniProtKB:P15303}.
Interaction partners:
Sequence:
MAEMADKAKVEEMDWEGIDGVRMTWNLWPRTKVEASKCVIPLAASISPIRRHPLILDLPYAPLDCKTCKALLNAFARVDFAAMNWVCPFCYHRNHFPSHYHSISEINLPGELYPQYTTVEYTLPPDPSRVPPPPVFVFVLDTCMIEEELGYAKSALKQAIGLLPENALVGFVSFGTQAHVHELGFSEMSKVFVFKGNKEVTKDQILDQLGLGSSSRRAPTSGFSKGAQNGFQSSGVDRFLLPASECEYTLDLLLDELQSDQWPVQPGHRPQRCTGVALSVAAGLLGACLPGTGARIVALVGGPCTEGPGTIISKDLSDPVRSHKDLDKDAAPYYKKAVKFYDSIAKQLVAQGHVLDLFASALDQVGVAEMKVAVESTGGLVVLSESFGHSVFKDSFKRMFEDGEHSLGLCFNGTLEINCSKDIKIQGVIGPCSSLEKKGPNVADTVIGEGNTSAWKLCGLDKSTCLTVFFDLSSTGSTAPGALNQQLYLQFITRYQNSEGKSLARVTTLTRQWVDTAVSTENLVQGFDQETAAVVMARLTSLKMETEEGFDATRWLDRTLIRLCSKFGEYRKDDPTSFTLKPYLTLFPQFMFNLRRSQFVQVFNNSPDETAYFRMLLNRENISNAIVMIQPSLTSYSFNSGPQAALLDVASIAADKILLLDAYFSVVVFHGMTISQWRNMGYHHQPEHEAFAQLLQAPQEDSQMLVRERFPVPRLVVCDQHGSQARFLLAKLNPSATYNNANEMSAGSDIIFTDDVSLQVFIEHLQKLAVQS
Protein: E protein transcript A (Q9N2Q1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYENFFQDNQVNYFGVIGVGKDDQVEITSNAFSHNKGGFPNIEIRNVLRVFLREKFLTGADYKLLVEDVTQLSVFSNALQKTNLDCSLKRIKELNLMKNAFNPGVAKYGINLRIEDSNINQLGIFGVSMGKVSLLRCHIDMIMSNAFDVTSIKELIIEGCNIEVIESQALTNKLHSDKVAIVDTVIGTIEGQAISQSGITTMIMFGNTITKIRSNAIQIVAISLFIRNNSMSHVEPNWLSVSQADQVEIANNRFEDYGRCELNIGSSNCSFRNNILQNPQSGSLNFTCRVHQVRVGTECSCNKSWLSELTDHDLESEIMCQVAKRDANCFNATNTDVRRYVNEACGSNVTRYCMGGQWVTKAVSDHSSDSSKLTIGMIALEIVILTLLLVAIVCVLAKNCGSGSCAPAGGQSTDNCLIEEDIRNSLRQLALHSESNKTRKAILKLINGHLSKGECNDRILFIVDNMPQNQAIESLLFRHISQSHMEPSDSEAYASTALTANATAPPLPPSTDSSEPIYQELDQQRLIIDDKYSLPLNSDEDPPYSEPSNMMSEYGNDYNYNGTNESYTSEQSNPSPNRPLLPIPNRL
Protein: Inactive cysteine S-methyltransferase OspZ (Protein ORF212) (Q2TH00)
Organism: Shigella flexneri
Function: Inactive effector protein: in contrast to other members of the family, does not have the ability to inhibit host cell NF-kappa-B activation. Probably lacks cysteine S-methyltransferase activity due to its inability to bind S-adenosyl-L-methionine at the C-terminus (Probable).
Subcellular location: Secreted {ECO:0000269|PubMed:17984206}. Host cytoplasm {ECO:0000269|PubMed:17984206}. Host nucleus {ECO:0000269|PubMed:17984206}. Note=Secreted via the type III secretion system (T3SS) (PubMed:17984206). Mainly localizes in the cytoplasm of the infected cells, and occasionaly in the host nucleus (PubMed:17984206). {ECO:0000269|PubMed:17984206}.
Interaction partners:
Sequence:
MISPIKNIKNVFPINTANTEYIVRNIYPRVEHGYFNESPNIYDKKYISGITRSMAQLKIEEFINEKSRRLNYMKTMYSPCPEDFQPISRAEASTPEGSWLTVISGKRPMGQFSVDSLYHPDLHALCELPEISCKIFSKENSDFLYIIVVFRNDSPQGELRANRFIELYDIKREIMQVLRDESPEIKVY
Protein: NFS1 cysteine desulfurase (NFS1 nitrogen fixation 1 homolog (S. cerevisiae)) (Q8WV90)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAPEVGPVLRPLYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGATESNNIAIKTESHSVIQAGVQWHDLDSLQAPPPGFTPFSCLSLLSSWDYRRPPPHPANFLYF
Protein: CorA-like Mg2+ transporter protein (Q57V77)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MIPNGGEAAGASREHTQGQNAGSCALNVGTNGKWEPYGYNYREREQSHLNSSRGAPLQVRVVVQLPNGTVREWKDFAQLQALPQILREVYTTTPDQGRSSAGSLSPLKFFWIDMSGMPQREDLSALFELLHVCKHTERRWRAMAAAPPGVGLGGFPLNNGTCEEGAERSHYDEDDYYDNATELDYLRAFVAEQYVQISLTVLESPNVTVYGLPMEKDTEREMGTEKHQRQREGSRPNLLDACESGTLASVQVLCFVNGVVTWRPQPAVEGWEYIPHGLERRLSNSTNIGDGRAVGDGNEGPRGALTTSLLVLTILDELYMAFLPDTTIVLSEVDTIDSMLPLVRQRMSDQADILRRIQMLRRSLSVHRRVLMSKVSVLELLSRPTVRVLLPFMNPITDAVNEKEREHCREPFDPRVYQPRHRHGELHYDQSEAMARRAPSSGQQSDTYADIACRILHVLSKLEDARRILTNSIIIHSSGVAAVNNYNSNQSDTLSITLGYVALMSLPPTIVASQWGMNVYVPWVDTNSTVPFWGIVGAVTAYAALVLSYPIFCWIRGRPDKLVF
Protein: Allergen Asp F4 (AFU_orthologue AFUA_2G03830) (Q5B6M6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MQLKNSLVLLTALTAGSSVARLHGHERRHAHHEKRDVGDLVTAIIDGKVVSWVNEYAGGAAATATATESTSTSLSETVAASTTASTETPSASAVSSASGTCANWDDESDEYSTAGFGSRTVSNNAKYVAYVGNVGNPWGSNIIEVDADKACKYKNVVKFSGSETDDWTIVFWNKIGPDGLLTGWYGNSALKLTISPGETKYVAFDDDSQGAWGAAKGDSLPTDEFGGYSCTWGEFDFGSSGNNDWSGWDVSAIQAQAANQDVQGMKICNNKGEKCSWISNLATAMENAYSKAEEGVDGIGGNQAPGAVRLVVDIDYTHSS
Protein: DNA replication complex GINS protein PSF3 (Q9W2V7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367161}.
Interaction partners:
- DNA replication licensing factor Mcm5
- DNA replication licensing factor Mcm3
- Probable DNA replication complex GINS protein PSF2
- CDC45L
- DNA replication licensing factor Mcm2
- DNA replication licensing factor MCM4
- DNA replication licensing factor Mcm7
- DNA replication licensing factor Mcm6
- DNA replication complex GINS protein SLD5
- DNA replication complex GINS protein PSF1
Sequence:
MNGMNYFPNYYSIEDIFVTQEKVECRVNTKLQRMGFLDSGAESDDLEPGRTVNLPLWYIKELKVNNAYFTVAVPDIYRNVHKAVCEAETTHIELGRLHPYFYEFGRYLTPYDRNHVIGRIIFETLRQRVRHLLDISKSDGQAAKAEHRLDNIEAKLHEAGVRTNSQYIEWLQMTGNKIRTSELVEEHQKKRRRADRSDDEGDALPNSKRATL
Protein: Histidine biosynthesis bifunctional protein his7 [Includes: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19); Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)] (O59667)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Histidinol dehydrogenase
- ATP phosphoribosyltransferase
- 1-
- Imidazole glycerol phosphate synthase hisHF
- Imidazoleglycerol-phosphate dehydratase
- Histidinol-phosphate aminotransferase
- Tryptophan synthase
- ATP-dependent helicase rhp16
- Multifunctional tryptophan biosynthesis protein
- Probable histidinol-phosphatase
Sequence:
MALLPFFDLTNFESDASEELGWLKYVGRVQTRVFPQHFKDNLEKVRKISETIDVIVDTTAELGPEACVNLLNAGALAILVNEEMLNELADISPNRLVLKTDTTDIGKIEKLSQVAGSIQWIGSAENYPPDFFERASKIIHKAVMPEGGGRTLYLEFPEQPSMEVLKSFSVHSVVPVLSSSFLTVKPAEEPKKLSLADLILISANTDREDGLFSTLVVNELGIALGLVYSSKESVAESLKTGTGVYQSRKRGLWYKGASSGAVQHLIHIDVDCDEDCLRFVVYQTGKGFCHLDTLHCFGQASGLCQLEKTLIDRKNNAPEGSYTARLFSDPKLLRAKIMEEAEELCDATTKENVIWEMADLMYFAITRCVGSGVSLNDISRHLDLKHRKVTRRKGDAKVAWQEKLKDKGGVANTSYTA
Protein: Polyadenylate-binding protein (PABP) (Q9U302)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU362004}.
Interaction partners:
- ATP-dependent RNA helicase cgh-1
- Prion-like-
- Protein LSM14 homolog car-1
- Ataxin-2 homolog
- Eukaryotic initiation factor 4A
- Eukaryotic peptide chain release factor GTP-binding subunit
- Polyadenylate-binding protein
- PAN2-PAN3 deadenylation complex subunit PAN3
- MIF4G domain-containing protein
- Nuclear cap-binding protein subunit 2
Sequence:
MEMNVAAPAAAVAGAAAPQPGQNQTGSSYTMASLYVGDLHPDVNESILFEKFSAAGPVLSIRVCRDNATRLSLGYAYVNFQQPADAERAMDTMNFEALHGKPMRIMWSQRDPAMRRSGAGNIFIKNLDKVIDNKSIYDTFSLFGNILSCKVAIDEDGFSKGYGFVHFETEEAAQNAIQKVNGMLLAGKKVFVGKFQPRAQRNRELGETAKQFTNVYVKNFGDHYNKETLEKLFAKFGNITSCEVMTVEGKSKGFGFVAFANPEEAETAVQALHDSTIEGTDLKLHVCRAQKKSERHAELKKKHEQHKAERMQKYQGVNLYVKNLDETVDDDGLKKQFESYGNITSAKVMTDENGRSKGFGFVCFEKPEEATSAVTEMNSKMVCSKPLYVAIAQRKEDRRAQLASQYMQRLASMRMHGNVPGAAMYNPTQPGPGYYVANPMQQQRNFAGGQQMVRPGGRWGMQNQYPVQNQYMMAQGPGVYQNRMGRPQNQQGGPRGPPQQYNQVAQGGVRMQGPPRTQNPGVQQQNVPRPPQQQQQQRPAPTGPKAPPQPYQAYQQRPQGIVIGGQEPLTSAMLAAAAPQEQKQLLGERIYALIEKLYPGHKDAGKITGMMLEIDNSELIMMLQDSELFRSKVDEAASVLVSAQKQ