wanglab/gogpt-training-data huggingface dataset:
Protein: RNA polymerase I-specific transcription initiation factor RRN10 (P38204)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- RNA polymerase I-specific transcription initiation factor RRN9
- Upstream activation factor subunit UAF30
- RNA polymerase I-specific transcription initiation factor RRN5
- RNA polymerase I-specific transcription initiation factor RRN6
- RNA polymerase I-specific transcription initiation factor RRN7
- Histone H3
- RNA polymerase I-specific transcription initiation factor RRN11
- TATA-box-binding protein
- Histone H4
- RNA polymerase I-specific transcription initiation factor RRN3
Sequence:
MDRNVYEACSNIIKEFGTHVVSADEVLAEKIDNAVPIPFKTREEIDADVEKDRNEGVFEGNIIPDIDLRVVHYYATQLCLNKYPHLINAFDETSLITLGLLIEKWVKDYLTSIQTEQGRQSKVIGKGPCEFISKHIDYRHAPGNI
Protein: Regulatory protein E2 (D7GMV3)
Organism: Human papillomavirus 11
Subcellular location: Host nucleus {ECO:0000256|ARBA:ARBA00004147, ECO:0000256|HAMAP-Rule:MF_04001}.
Interaction partners:
Sequence:
MEAIAKRLDACQDQLLELYEENSIDIHKHIMHWKCIRLESVLLHKAKQMGLSHIGLQVVPPLTVSETKGHNAIEMQMHLESLAKTQYGVEPWTLQDTSYEMWLTPPKRCFKKQGNTVEVKFDGCEDNVMEYVVWTHIYLQDNDSWVKVTSSVDAKGIYYTCGQFKTYYVNFNKEAQKYGSTNHWEVCYGSTVICSPASVSSTVREVSIAEPTTYTPAQTTAPTVSACTTEDGVSAPPRKRARGPSTNNTLCVANIRSVDSTINNIVTDNYNKHQRRNNCHSAATPIVQLQGDSNCLKCFRYRLNDKYRHLFELASSTWHWASPEAPHKNAIVTLTYSSEEQRQQFLNSVKIPPTIRHKVGFMSLHLL
Protein: Nephrin (Renal glomerulus-specific cell adhesion receptor) (Q9R044)
Organism: Rattus norvegicus (Rat)
Function: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Located at podocyte slit diaphragm between podocyte foot processes. {ECO:0000269|PubMed:10792613}.
Interaction partners:
- Podocin
- CD2-associated protein
- Kin of IRRE-like protein 1
- Kirre like nephrin family adhesion molecule 3
- Transient receptor potential Ca2+ channel 6A
- Alpha-actinin-4
- Kin of IRRE-like protein 2
- NCK adaptor protein 1.
- Tight junction protein ZO-1
- Peripheral plasma membrane protein CASK
Sequence:
MGAKRVTVRGARTSPIHRMSSLTPLLLMGMLTSGLAESPVPTSAPRGFWALSENLTAVEGTTVKLWCGVRAPGSVVQWAKDGLLLGPNPKMPGFPRYSLEGDRAKGEFHLLIEACDLSDDAEYECQVGRSELGPELVSPKVILSILVSPKVLLLTPEAGSTVTWVAGQEYVVTCVSGDAKPAPDITFIQSGRTILDVSSNVNEGSEEKLCITEAEARVIPQSSDNGQLLVCEGSNPALDTPIKASFTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCTARGGNPPATLQWLKNGKPVSTAWGTEHAQAVAHSVLVMTVRPEDHGARLSCQSYNSVSAGTQERSITLQVTFPPSAITILGSVSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDETVMDGLHGGHISMSNLTFLVRREDNGLPLTCEAFSDAFSKETFKKSLTLNVKYPAQKLWIEGPPEGQYIRTGTRVRLVCLAIGGNPDPSLIWFKDSRPVSEPRQPQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNRAKFSCKAGQLSASTQLVVQFPPTNLTILANSSALRPGDALNLTCVSISSNPPVNLSWDKEGERLEDVAAKPQSAPFKGSAASRSVFLRVSSRDHGQRVTCRAHSEALRETVSSFYRFNVLYPPEFLGEQVRAVTVVEQGQVLLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSEGTAEALLKLDVHYAPTIRALRDPTEVNVGGSVDIVCTVDANPILPEMFSWERLGEEEEDLNLDDMEKVSKGSTGRLRIRQAKLSQAGAYQCIVDNGVAPAARGLVRLVVRFAPQVDQPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHRYHQGVVHSSLLTIANVSAAQDYALFKCTATNALGSDHTNIQLVSISRPDPPLGLKVVSISPHSVGLEWKPGFDGGLPQRFQIRYEALETPGFLHVDVLPTQATTFTLTGLKPSTRYRIWLLASNALGDSGLTDKGIQVSVTTPGPDQAPEDTDHQLPTELPPGPPRLPLLPVLFAVGGLLLLSNASCVGGLLWRRRLRRLAEEISEKTEAGSEDRIRNEYEESQWTGDRDTRSSTVSTAEVDPNYYSMRDFSPQLPPTLEEVLYHQGAEGEDMAFPGHLHDEVERAYGPPGAWGPLYDEVRMDPYDLRWPEVQCEDPRGIYDQVAADMDAVEASSLPFELRGHLV
Protein: Small ribosomal subunit protein eS8 (40S ribosomal protein S8) (P62242)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}. Membrane {ECO:0000250|UniProtKB:P62241}; Lipid-anchor {ECO:0000250|UniProtKB:P62241}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62241}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250|UniProtKB:P62241}.
Interaction partners:
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein eL37
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL6
Sequence:
MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKGK
Protein: Nucleoside diphosphate kinase homolog 7 (NDK 7) (NDP kinase homolog 7) (3'-5' exonuclease NME7) (EC 3.1.-.-) (Protein kinase NME7) (EC 2.7.-.-) (nm23-H7) (Q9QXL8)
Organism: Mus musculus (Mouse)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y5B8}. Nucleus {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9Y5B8}. Note=Localizes to centrosomes through its assembly into gamma-tubulin ring complex. The centrosomal content of NME7 varies during the cell cycle, being highest in mitosis and lowest in early G1. {ECO:0000250|UniProtKB:Q9Y5B8}.
Interaction partners:
- Mitotic-spindle organizing protein 1
- Gamma-tubulin complex component 5
- Mitotic-spindle organizing protein 2
- Gamma-tubulin complex component 4
- Inosine triphosphate pyrophosphatase
- Thymidylate kinase
- Protein NEDD1
- Adenylate kinase 9
- CTP synthase 1
- U8 snoRNA-decapping enzyme
Sequence:
MRACQQGRSSSLVSPYMAPKNQSERFAFIAEWYDPNASLLRRYELLFYPTDGSVEMHDVKNRRTFLKRTKYEDLRLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICEWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSSGGCGPANTAKFTNCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSEYNDMVTELCSGPCVAIEIQQSNPTKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFKILDN
Protein: Potassium transporter (F4JU14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU321113}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU321113}.
Interaction partners:
Sequence:
MAERVEASSVPEGENTIEEREVGAMWELEQKLDQPMDEEANKLNNMYREKGLSMLMLLRLSFQSLGIVYGDLGTSPLYVFYNTFPDGIDDSEDVIGALSLIIYSLLLIPLIKYVFIVCKANDNGQGGTLAIYSLLCRHAKVKLIPNQHRSDEDLTTYSRTVSAEGSFAAKTKKWLEGKEWRKRALLVVVLLGTCMMIGDGILTPAISVLSATGGIKVNNPKMSGDIVVLVAIVILIGLFSMQHYGTDKVGWLFAPIVLIWFLFIGATGMYNICKYDTSVLKAFSPTYIYLYFKRRGRDGWISLGGILLSITGTEALYADIAYFPLLAIQLAFTFFVFPCLLLAYCGQAAYLVIHKEHYQDAFYASIPDSVYWPMFIVATGAAIVGSQATISGTYSIVKQAVAHGCFPRVKIVHTSKKFLGQIYCPDINWILMLGCIAVTASFKKQSQIGNAYGKMTTTSKYKKNYFSQWTAVVLVMLVTTLLMVLIMLLVWHCHWILVLIFTFLSFFVELSYFSAVIFKIDEGGWVPLIIAAISLLVMSVWHYATVKKYEFEMHSKVSMSWILGLGPSLGLVRVPGIGLVYTELASGVPHIFSHFITNLPAIHSVVVFVCVKYLPVYTVPEEERFLVKRIGPKTFRMFRCVARYGYKDLHKKDDDFENKLLTKLSSFIRIETMMEPTSNSSTYSSTYSVNHTQDSTVDLIHNNNNHNHNNNMDMFSSMVDYTVSTLDTIVSAESLHNTVSFSQDNTVEEEETDELEFLKTCKESGVVHIMGNTVVKARTGSWLPKKIAIDYVYAFLAKICRANSVILHVPHETLLNVGQVFYV
Protein: Uncharacterized protein C1259.08 (O94708)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Protein transport protein sec31
- Protein transport protein sec24
- Membrane glycoprotein spo14
- Protein transport protein sec23-1
- Protein transport protein sec23-2
- Sad1-interacting factor 1
Sequence:
MTGLLSILLHYKGNGDLATTDIPSHEKIPSAKRTAVQFCIGPTHEQSPRMSTVSQGRVTFAVLPTKPKDEVTSMKANGSRQSSCIVSNARKRQSVHCLSRSPIPSTRLKENDSRLCSPLASPTGGLKRPAKVSFALANTPSRKGNLVPQSPRRTIATTCKGVLEDVLKKDNELKFNDSDEEDEVDDEEIESFNSFSRKMQTISNSRYRGSPKPNIEKQSCSSESDRVSQISDDEEDEEGSADEEDEEDSDVELSESSLSDDEDSPLRCPSTPVQTAAAPNESQIPDDTDFVPGTFDEDQPACLAFACSLTHANSKRSIMLPQDIDPTFPDSEPEDDGHASSTVGSLSKEEARFKAKAKWNYKSSFSAHVSSEVLRNSKSPPLDIARKAVGAHRV
Protein: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (F2Z3X7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDRLTQSLDSDKPKEPVKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQVTEPKVPQKLPAGRHTSKHGTLRGPSSSSNRTTKPSHANYSLDDITAQLEQASLSMDEAAQQSLVEDPKPLVTNQHRRTASAGTVSDAEARSISNSSRSSIT
Protein: Mannan polymerase complexes subunit MNN9 (M-pol I subunit MNN9) (M-Pol II subunit MNN9) (P39107)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The M-Pol I and M-Pol II complexes possess alpha-1,6-mannosyltransferase activity and are probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins. May also provide alpha-1,2-mannosyltransferase activity to the M-Pol I complex.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11095735}; Single-pass type II membrane protein {ECO:0000305|PubMed:9434768}. Golgi apparatus membrane {ECO:0000269|PubMed:9434768}; Single-pass type II membrane protein {ECO:0000305|PubMed:9434768}. Note=Cis-Golgi (PubMed:9430634). Recycles between endoplasmic reticulum and Golgi (PubMed:11095735). {ECO:0000269|PubMed:11095735, ECO:0000269|PubMed:9430634}.
Interaction partners:
- Putative glycosyltransferase HOC1
- Probable alpha-1,6-mannosyltransferase MNN10
- Probable alpha-1,6-mannosyltransferase MNN11
- Mannan polymerase II complex ANP1 subunit
- Mannan polymerase I complex VAN1 subunit
- Alpha-1,2-mannosyltransferase MNN2
- Initiation-specific alpha-1,6-mannosyltransferase
- Dolichyl-phosphate-mannose--protein mannosyltransferase 2
- Dolichyl-phosphate-mannose--protein mannosyltransferase 5
- Dolichyl-phosphate-mannose--protein mannosyltransferase 3
Sequence:
MSLSLVSYRLRKNPWVNIFLPVLAIFLIYIIFFQRDQSLLGLNGQSISQHKWAHEKENTFYFPFTKKYKMPKYSYKKKSGWLFNDHVEDIIPEGHIAHYDLNKLHSTSEAAVNKEHILILTPMQTFHQQYWDNLLQLNYPRELIELGFITPRTATGDLALKKLENAIKKVQTDKKTQRFSKITILRQNSQSFDKLMEKERHALDVQKERRAAMALARNELLFSTIGPHTSWVLWLDADIIETPPSLIQDMTKHNKAILAANIYQRFYDEEKKQPSIRPYDFNNWQESDTGLEIASQMGDDEIIVEGYAEIATYRPLMAHFYDANGVPGEEMALDGVGGGCTLVKAEVHRDGAMFPNFPFYHLIETEGFAKMAKRLNYDVFGLPNYLVYHIEEENH
Protein: Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (H0ZLY1)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR002527}.
Interaction partners:
Sequence:
MATACWEQCGLPAADLTVDSESRYVPCSLPLVLTMTLHTKTSGVTLLHQIQGTELETLSRPQLKIPLERSLSDMYVETNKTGVFNYPEGATYDFGTTAPVYSSTTLSYAPTSESFGSSSLAGFHSLNSVPPSPVVFLQTAPQLSPFIHHHSQQVPYYLENDQGSFGMREAAPPAFYRPNSDNRRHSIRERMSSANEKGSLSMESTKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRVMKQKRQREEQDSRNGEASSTELRAPTLWASPLVVKHNKKNSPALSLTAEQMVSALLEAEPPLVYSEYDPNRPFNEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATAARFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDYIHRVLDKITDTLIHLMAKSGLSLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPAARSAAPMEEENRSQLTTASASSHSLQSFYINSKEEENMQNTL
Protein: Ribonuclease K6 (RNase K6) (EC 3.1.27.-) (Q9D244)
Organism: Mus musculus (Mouse)
Function: Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:25075772}. Lysosome {ECO:0000305|PubMed:25075772}. Cytoplasmic granule {ECO:0000269|PubMed:25075772}.
Interaction partners:
Sequence:
MVVDLPRYLPLLLLLELWEPMYLLCSQPKGLSRAHWFEIQHIQTSRQPCNTAMRGVNNYTQHCKQINTFLHESFQNVAATCSLHNITCKNGRKNCHESAEPVKMTDCSHTGGAYPNCRYSSDKQYKFFIVACEHPKKEDPPYQLVPVHLDKIV
Protein: Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin) (P60568)
Organism: Homo sapiens (Human)
Function: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
Subcellular location: Secreted.
Interaction partners:
- Interleukin-2 receptor subunit beta
- Interleukin-4
- Interleukin-6
- Interleukin-1 beta
- Interleukin-2 receptor subunit alpha
- Cytokine receptor common subunit gamma
- Tyrosine-protein kinase JAK3
- Interleukin-5
- Interleukin-3
- Interleukin-7
Sequence:
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Protein: Hydrogenase-2 operon protein HybE (P0AAN1)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Hydrogenase-2 small chain
- Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit
- Hydrogenase maturation factor HybF
- Hydrogenase 2 maturation protease
- Hydrogenase-2 large chain
- Hydrogenase-2 operon protein HybA
- Hydrogenase maturation factor HybG
- Hydrogenase-1 operon protein HyaE
- Chaperone protein YcdY
- Hydrogenase 1 maturation protease
Sequence:
MTEEIAGFQTSPKAQVQAAFEEIARRSMHDLSFLHPSMPVYVSDFTLFEGQWTGCVITPWMLSAVIFPGPDQLWPLRKVSEKIGLQLPYGTMTFTVGELDGVSQYLSCSLMSPLSHSMSIEEGQRLTDDCARMILSLPVTNPDVPHAGRRALLFGRRSGENA
Protein: Aminopeptidase (EC 3.4.11.-) (B2R8K9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISIDLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGRVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
Protein: Protein phosphatase 6 regulatory subunit 3 (E9PQP7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQDVLNKSVMKTTWGVLDPPVGNTRLNVIRLISSLLQTNTSSINGDLMELNSIGVILNMFFKYTWNNFLHTQVEICIALILASPFENTENATITDQDSTGDNLLLKHLFQKCQLIERILEAWEMNEKKQAEGGRRHGYMGHLTRIANCIVHSTDKGPNSALVQQLIKDLPDEVRERWETFCTSSLGETNKRNTVDLVTTCHIHSSSDDEIDFKETGFSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALFEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNWSANFDVPMETTHGAPLDSVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGEEDAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKSEEGKLSTSQDAACKDAEECPETAEAKCAAPRPPSSSPEQRTGQPSAPGDTSVNGPV
Protein: Coiled-coil domain-containing protein 124 (Q96CT7)
Organism: Homo sapiens (Human)
Function: Required for proper progression of late cytokinetic stages.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23894443}. Midbody {ECO:0000269|PubMed:23894443}. Note=Colocalizes with gamma-tubulin at interphase, prophase, metaphase, and anaphase. Relocates from centrosome to midbody at telophase.
Interaction partners:
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein eS7
Sequence:
MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRAVPFNAPK
Protein: Mitochondrial dynamics protein MID49 (Mitochondrial dynamics protein of 49 kDa homolog) (Mitochondrial elongation factor 2) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog) (Q5NCS9)
Organism: Mus musculus (Mouse)
Function: Mitochondrial outer membrane protein which regulates mitochondrial organization. It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:24508339}; Single-pass membrane protein {ECO:0000269|PubMed:24508339}. Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria.
Interaction partners:
- Dynamin-1-like protein
- Mitochondrial fission factor
- Mitochondrial fission 1 protein
- Mitofusin-2
- Dynamin-like GTPase OPA1, mitochondrial
- Mitofusin-1
- Dynamin-1
- Dynamin-2
Sequence:
MAEFSQKQRKQSGSEGLGSVVDFLLANARLVLGVGGAAVLGIATLAVKRLIDRATSPPDEDDTKGDSWKELSLLRATSPQKPQPPPAAFSQPLATGSPSPSVPVEPTPIHSPTTPKFSTIAPLCLTFQERLLAFERKHVITPEAHVTLAKQLAGDIALELQAYLRSKFPELPFGALVPGGPLYDGLQAGTAEHVRLLAPLELEPGLWSLVPGVDTVAREPRCWAVRRTQLEFHPRGCSPWDRFLVGGYLSSRVLLELLRKALSASVNWPAIGSLLGCLIWPDVASEELLLKVQHECLEFTLAVLMVVPGASTDDRLLLAWPLEGLASNLWLQDLYPVETARLRALDDQDAGTRRRLLLLLCGICRGHPALVRLGWSHLTQVVLHLGEEEVAWTEEALGERFLQALEFLVGSLEQASLPCHFNPSVNLLGNFREEEIDDIGYVLYSGLQVPESLF
Protein: Zinc finger protein 14 (Zfp-14) (Zinc finger protein Krox-9) (P10755)
Organism: Mus musculus (Mouse)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MALAQGLVTFGDVAVDFSQEEWEFLDPAQKNLYRDVMWETYSNFISLDLESRFKTDTSSSDKGICEVYSLQWELIEKIKNLSPQGSGLSDDQECKHKTGLQKEPQEGYFGQLKITSEKVTYEKHSFLSEYQRVQNGEKFYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQPFRQRAHLIRHHKLHTGEKPYECKDCGKAFTVLQELTQHQRLHTGEKPYECKECGKAFRVHQQLARHQRIHTGEKPYECKECGKTFRQCTHLTRHQRLHTSEKLYECKECGKAFVCGPDLRVHQKIHFGEKPYACKDCGKSFRICQQLTVHQSIHTGEKPYECKECGKTFRLRQQLVRHQRIHTHERPYECLECWKTFSSYSQLISHQSIHVGERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECQECRKPFRLLSQLTQHRSIHTGEKPYECKDCGKAFRLYSFLSQHQRIHTGEKPYKCKECKKAFRQHSHLTQHQKIHSGT
Protein: Hippocalcin-like protein 4 (Neural visinin-like protein 2) (NVL-2) (NVP-2) (Visinin-like protein 2) (VILIP-2) (P35332)
Organism: Rattus norvegicus (Rat)
Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
Interaction partners:
Sequence:
MGKNNSKLAPEELEDLVQNTEFSEQELKQWYKGFLKDCPSGILNLEEFQQLYIKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSVTSRGSFEQKLNWAFEMYDLDGDGRITRLEMLEIIEAIYKMVGTVIMMRMNQDGLTPQQRVDKIFKKMDQDKDDQITLEEFKEAAKSDPSIVLLLQCDMQK
Protein: Peroxisomal ATPase PEX1 (Peroxin-1) (A0A1D8PR43)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Peroxisomal ATPase PEX6
- Peroxisomal membrane protein PEX13
- Peroxisomal targeting signal receptor
- Pex19p
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX14
- RING-type E3 ubiquitin transferase
- Peroxin-7
- Ubiquitin-conjugating enzyme E2-21 kDa
- Peroxin-3
Sequence:
MDNHKARISYKTLKSNLVNLPSSLTNLLFTANIQVQDVIIEMVTTTSNGNKKNSTTTKHYAGWSGMSSSDISNLEIDPVFAQSLNLIDKTPIIVNLKLGNYESTNINLEPLTSSDWELVELHAQSIEDKLLSQTRCVALNQVLVVYPSATTSAKLLVTDLGSTDHTFAKISPYCEIAIAPKVREKEQKNNKTASSSKSIASSKSTKRTTSSSSEDYSDLPSVLKRGISLPHKLYNVNEAVAGYFVYVDIDDELPQGFNSEYVAVSVIPGPNDKTSTKALQATEDDNNNNNSNNNNKNLKENKRIIAKLVDYKSGPSGNIGLSRNLAIALNIENQIGNIISLKPAIKNLPKRPTTFTIHPYIIHTKKKEITISSNKKENKLAQQLTEIMYPGIASIPITNFTKIPIIANILPYGGLLRFRKNDEYNAWIKPYNLDSKKPIKFEIGDEILRPSSFIEQEIDKPTTNDTEEQEAIGLDNTVEDIVDSFITSDNTGTLVYGNSGSGKTLLLKLVAQQLNQQHGYFTKYISCDTIMNENFQNLSKNHFFKWIQTCAWNKPSVLILDNIDKLMSVEMENMDATKSNQLTEFFISNLTKIHHQLNSNLSILLSANSKDNINKLLLGSHLIENFHHLNPPDKSLRFEILDKYLTNKLGLKIKVDLMDLVSETEGYLPNDLKILSDRIYHEVLFNSTETETETETEATTNAAVTSEHIEKALAGYTPSNLRGVKLQKSSINWSDIGGLKEAKNILLETLEWPTKYAPIFANCPLRLRSGILLYGYPGCGKTLLASAIAGQCGLNFISIKGPEILNKYIGASEQSVRELFERAQAAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQMLTQMDGAEGLDGVYVLAATSRPDLIDSALLRPGRLDKSVICDMPNYEDRLDILQSITTKMDLSDDVNLHEIAEKTTGFSGADMQGLGYNAYLKAVHVTLEELSQREQDEANNEDGNNNFEKNSIEFFQVGNSEKKLKTNEKIQLLHQIQQFMNPNKDNSDSERKAGQDAMNKSKVLITHENFLESLKETKPSISHSEKIKLTKIYKEFVNDRDGNMPDGTPSNEIGGRTTLM
Protein: Transcription initiation factor IIE subunit beta (E1JIC9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR016398}.
Interaction partners:
Sequence:
MRPPNAPRLDATTYKTMSGSSQYRFGVLAKIVKFMRTRHQDGDDHPLTIDEILDETNQLDIGQSVKNWLASEALHNNPKVEASPCGTKFSFKPVYKIKDGKTLMRLLKQHDLKGLGGILLDDVQESLPHCEKVLKNRSAEILFVVRPIDKKKILFYNDRTANFSVDDEFQKLWRSATVDAMDDAKIDEYLEKQGIRSMQDHGLKKAIPKRKKAANKKRQFKKPRDNEHLADVLEVYEDNTLTLKGVNPT