Protein: Helicase ssl-1 (EC 3.6.4.-) (Swi/snf2-like protein 1) (Q9NEL2)
Organism: Caenorhabditis elegans
Function: Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549}.
Interaction partners:
- RuvB-like 2
- Histone H2A.V
- RuvB-like 1
- DNA methyltransferase 1-associated protein 1
- HIT-type domain-containing protein
- Actin-like protein C08B11.6
- Actin-related protein 4
- Vacuolar protein sorting-associated protein 72 homolog
- Craniofacial development protein 1
- Mortality factor related protein 1
Sequence:
MPATPVRASSTRISRRTSSRSVADDQPSTSSAVAPPPSPIAIETDEDAVVEEEKKKKKTSDDLEIITPRTPVDRRIPYICSILLTENRSIRDKLVLSSGPVRQEDHEEQIARAQRIQPVVDQIQRVEQIILNGSVEDILKDPRFAVMADLTKEPPPTPAPPPPIQKTMQPIEVKIEDSEGSNTAQPSVLPSCGGGETNVERAAKREAHVLARIAELRKNGLWSNSRLPKCVEPERNKTHWDYLLEEVKWMAVDFRTETNTKRKIAKVIAHAIAKQHRDKQIEIERAAEREIKEKRKMCAGIAKMVRDFWSSTDKVVDIRAKEVLESRLRKARNKHLMFVIGQVDEMSNIVQEGLVSSSKSPSIASDRDDKDEEFKAPGSDSESDDEQTIANAEKSQKKEDVRQEVDALQNEATVDMDDFLYTLPPEYLKAYGLTQEDLEEMKREKLEEQKARKEACGDNEEKMEIDESPSSDAQKPSTSSSDLTAEQLQDPTAEDGNGDGHGVLENVDYVKLNSQDSDERQQELANIAEEALKFQPKGYTLETTQVKTPVPFLIRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCSLSKRQRYLYDDFMSRRSTKENLKSGNMMSVLNIVMQLRKCCNHPNLFEPRPVVAPFVVEKLQLDVPARLFEISQQDPSSSSASQIPEIFNLSKIGYQSSVRSAKPLIEELEAMSTYPEPRAPEVGGFRFNRTAFVAKNPHTEESEDEGVMRSRVLPKPINGTAQPLQNGNSIPQNAPNRPQTSCIRSKTVVNTVPLTISTDRSGFHFNMANVGRGVVRLDDSARMSPPLKRQKLTGTATNWSDYVPRHVVEKMEESRKNQLEIVRRRFEMIRAPIIPLEMVALVREEIIAEFPRLAVEEDEVVQERLLEYCELLVQRFGMYVEPVLTDAWQCRPSSSGLPSYIRNNLSNIELNSRSLLLNTSTNFDTRMSISRALQFPELRLIEYDCGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADPKVFCFILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERTIEENILRKATQKRRLGELAIDEAGFTPEFFKQSDSIRDLFDGENVEVTAVADVATTMSEKEMEVAMAKCEDEADVNAAKIAVAEANVDNAEFDEKSLPPMSNLQGDEEADEKYMELIQQLKPIERYAINFLETQYKPEFEEECKEAEALIDQKREEWDKNLNDTAVIDLDDSDSLLLNDPSTSADFYQSSSLLDEIKFYDELDDIMPIWLPPSPPDSDADFDLRMEDDCLDLMYEIEQMNEARLPQVCHEMRRPLAEKQQKQNTLNAFNDILSAKEKESVYDAVNKCLQMPQSEAITAESAASPAYTEHSSFSMDDTSQDAKIEPSLTENQQPTTTATTTTTVPQQQQQQQQQKSSKKKRNDNRTAQNRTAENGVKRATTPPPSWREEPDYDGAEWNIVEDYALLQAVQVEFANAHLVEKSANEGMVLNWEFVSNAVNKQTRFFRSARQCSIRYQMFVRPKELGQLVASDPISKKTMKVDLSHTELSHLRKGRMTTESQYAHDYGILTDKKHVNRFKSVRVAATRRPVQFWRGPKALESRNLQSLNGGMPPRHESRLAEFDVKTNIRLDAEDIVTMSDESIVAYEASKKKLLASRQTKPSPRQDVRFHTLVLRPYTVPVTTEYSAAPSRREMRIAVPPLQPSALSTISSVAAAATSGPLPSIQHLQSSSTGLGSQQNLQNSHNSEQRNNVQNMHQNQYNSSQNPPIPIRQIGAASSHQHDQGSQGPGGKPQAYHLVQQGSQQQQQQQQQATLQRRNAAAAAGSNVQFIQQQQQQQQSGKNCGQGQSFVVMGSQSSSNDGQGGASTVGGGGGGSQQPHQQQQQQPQQRIQYIPQVTGSGNNGGGGGRGGYGSTLVMPRGGRVVRPAGTLPGGGRLYVDHNRHPYPMSSNVVPVRVLPATQQGQQRMMTGQRRPAPAPGTVAAMVLPNRGAGGIPQMRSLQRGSYTGGGGQQRINVMVQPQQMRSNNGGGVGGQGGLQGGPGGPQGIRRPLVGRPLQRGVDNQAPTVAQVVVAPPQGMQQASQGPPVLHMQRAVSMQMPTSHHHQGQQQAPPQSSQQASQQAPTSDSGTSAPPRQAPPPQN