wanglab/gogpt-training-data huggingface dataset:
Protein: Prolactin-2 (Prolactin II) (PRL-II) (P09584)
Organism: Oncorhynchus keta (Chum salmon) (Salmo keta)
Subcellular location: Secreted.
Interaction partners:
Sequence:
MARRSQGTKLHLAVLCLVVSCHAIGLSDLMERASQRSDKLHSLSTSLNKDLDSHFPPMGRVMMPRPSMCHTSSLQIPKDKEQALRVSENELISLARSLLLAWNDPLLLLSSEAPTLPHPSNGDISSKIRELQDYSKSLGDGLDILVNKMGPSSQYISSIPFKGGDLGNDKTSRLINFHFLMSCFRRDSHKIDSFLKVLRCRATKMRPETC
Protein: At1g78260 (RNA recognition motif-containing protein SEB-4) (RNA-binding (RRM/RBD/RNP motifs) family protein) (Q8LF90)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSQTSYYRSPFGDTTYTKVFVGGLAWETPTDEMRRYFEQFGEILEAVIITDKNTGKSKGYGFVTFRESDSATRAVADPNPVIDGRKANCNIASFGRPRPSPPRGRGQTGSPSQYQSGGPSTYTGMAAPLPPAAAPQLMYPSYGYTYNPDQFGYHQALYNTQLQQAQYYQQQQQLYGGGATSPSSSGATIMPSPYYYGYSLQAPRVPYQHHHHLPQPYNPQQHHHQRFSSPSFLVYPSNSSFAPPLQGVLSSSTESEAVPQQVPAAEGEATTTAPEITTSNTKEPISS
Protein: Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] (O35567)
Organism: Rattus norvegicus (Rat)
Function: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP (By similarity). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54113}.
Interaction partners:
- Adenylosuccinate lyase
- Trifunctional purine biosynthetic protein adenosine-3
- Adenylosuccinate synthetase isozyme 2
- Amidophosphoribosyltransferase
- Serine hydroxymethyltransferase
- Adenylosuccinate synthetase isozyme 1
- Serine hydroxymethyltransferase
- C-1-tetrahydrofolate synthase, cytoplasmic
- Adenine phosphoribosyltransferase
- Monofunctional C1-tetrahydrofolate synthase, mitochondrial
Sequence:
MASSQLALFSVSDKTGLVEFARNLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLIRVVVCNLYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYGAVAAEMQGSGNKDTSLETRRHLALKAFTHTAQYDEAISDYFRRQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLAIAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGSYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEGEDLVKWKALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH
Protein: Mast cell protease 1 (mMCP-1) (EC 3.4.21.-) (P11034)
Organism: Mus musculus (Mouse)
Function: Has a chymotrypsin-like activity.
Subcellular location: Secreted. Cytoplasmic granule. Note=Secretory granules.
Interaction partners:
- Mast cell protease 2
Sequence:
MQALLFLMALLLPSGAGAEEIIGGVEARPHSRPYMAHLKIITDRGSEDRCGGFLIAPQFVLTAAHCKGREITVTLGAHDVSKSESTQQRIKVEKQIIHKNYNVSFNLYDIMLLKLEEKAELTPTVDVIPLPGPSDFIDPGKMCWTAGWGKTGEKEPTSETLREVELRIMDKEACKMYKHYDYNFQVCVGSSTKLKTAYMGDSGGPLLCAGVAHGIVSYGDSHGKPPAVFTRISAYVPWIKTVINGK
Protein: Lon protease homolog, mitochondrial (EC 3.4.21.53) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) (K7EKE6)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|HAMAP-Rule:MF_03120}.
Interaction partners:
Sequence:
MTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER
Protein: Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) (P21279)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNA11, required for heart development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19001095}; Lipid-anchor {ECO:0000269|PubMed:19001095}. Golgi apparatus {ECO:0000250|UniProtKB:P50148}. Nucleus {ECO:0000269|PubMed:18802028}. Nucleus membrane {ECO:0000269|PubMed:18802028}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000269|PubMed:18802028}.
Interaction partners:
- Sphingosine 1-phosphate receptor 2
- Beta-adrenergic receptor kinase 1
- Sphingosine 1-phosphate receptor 3
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- 5-hydroxytryptamine receptor 2C
- Histamine H1 receptor
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
- Lysophosphatidic acid receptor 1
- Chaperone Ric-8A
- 5-hydroxytryptamine receptor 2B
Sequence:
MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
Protein: Spindle assembly checkpoint component MAD1 (Q54BH4)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MPRRATDNRRSQKQRIDQTVHKNFTEDENNLENNNINNNNSYIENNNDIENNNNNNNNINNNNITTNSNINVNNNKNNNLNNNNNNNLNNDDNNNNNLNNLNLFKRKYYELKDKVNEIKKIRFTETEQLFEDFKIRAEQRDTESRKVINKLKRELDNVNTSNRVLMESLKEGHGFNCEEIRKDILLKSKDDHEFTINQLKLFYEGRIEQLETDNQRVSNDFDSYRNQVIETQNKQNKERSEKEERDRILFENLTPSSERIQERRQQEAQLQRNLNEENDLMKLKEFIENLKVKYENEQRSNLEKHQDLVKKTQEKLKESSELLNRLENEKSDFANKYQQLSIKYQDKSNSYKELLSKIDDIKQSVLQDHEQLTQSKNKEIQQLQLTIKEKQLNYDQLQTSSKQIIDSLQKEIEEITIVNDKLLFDQLELKNAEIEELEKKHLSEIEEYEEKLLSSTDDSLKSIQKILNQFEQSKIDLNNSNLLNKTNENHLEIYKLLTGTNISIISENKFEVICQNPKYDAKVHGYITINEDDIYYDPISIDNCRNENEFLGTRLEFPKDEGMAFIVKLIEAVFR
Protein: Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) (Phospholipid-hydroperoxide glutathione peroxidase GPX1) (EC 1.11.1.12) (P00435)
Organism: Bos taurus (Bovine)
Function: Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P11352}. Mitochondrion {ECO:0000250|UniProtKB:P11352}.
Interaction partners:
- Glutathione reductase
- Peroxiredoxin-6
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Phospholipid hydroperoxide glutathione peroxidase
- Superoxide dismutase, mitochondrial
- Glutathione synthetase
- Uncharacterized protein.
- Glutathione peroxidase 7
- Probable glutathione peroxidase 8
- Polyunsaturated fatty acid lipoxygenase ALOX15
Sequence:
MCAAQRSAAALAAAAPRTVYAFSARPLAGGEPFNLSSLRGKVLLIENVASLUGTTVRDYTQMNDLQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNCLKYVRPGGGFEPNFMLFEKCEVNGEKAHPLFAFLREVLPTPSDDATALMTDPKFITWSPVCRNDVSWNFEKFLVGPDGVPVRRYSRRFLTIDIEPDIETLLSQGASA
Protein: Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine] (P78423)
Organism: Homo sapiens (Human)
Function: Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9024663}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Processed fractalkine]: Secreted {ECO:0000269|PubMed:9024663}.
Interaction partners:
- CX3C chemokine receptor 1
- C-C chemokine receptor type 2
- C-X-C chemokine receptor type 4
- C-X-C chemokine receptor type 1
- Eotaxin
- C-X-C chemokine receptor type 3
- C-C chemokine receptor type 5
- C-C motif chemokine 5
- Fibroblast growth factor 2
- Cell surface glycoprotein CD200 receptor 1
Sequence:
MAPISLSWLLRLATFCHLTVLLAGQHHGVTKCNITCSKMTSKIPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNGGTFEKQIGEVKPRTTPAAGGMDESVVLEPEATGESSSLEPTPSSQEAQRALGTSPELPTGVTGSSGTRLPPTPKAQDGGPVGTELFRVPPVSTAATWQSSAPHQPGPSLWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRVWGQGQSPRPENSLEREEMGPVPAHTDAFQDWGPGSMAHVSVVPVSSEGTPSREPVASGSWTPKAEEPIHATMDPQRLGVLITPVPDAQAATRRQAVGLLAFLGLLFCLGVAMFTYQSLQGCPRKMAGEMAEGLRYIPRSCGSNSYVLVPV
Protein: Kinesin-like protein KIF3A (Q9WV62)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
EEGELGEDGEKRKKRRDQAGKKKVSPDKMMEMQAKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKERDP
Protein: Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos) (P00539)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P00540}.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase 2
- Dual specificity mitogen-activated protein kinase kinase 1
- GTPase NRas
- GTPase HRas
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
- Heat shock protein HSP 90-beta
- Heat shock protein HSP 90-alpha
- Ras-related protein M-Ras
- RAS related 2
- Ras-related protein R-Ras
Sequence:
MPSPLILCRYLPRELSPTVDSRSCSSPLVASRAGKFLGATPPRAPRLSRRLAWCFIDWGQVCLLHRLGSGGFGSVYKATYHGVPVAIKQVNKCTRTLRASQRNFWAELNIARLHHDNIIRVVAASTRTPEGSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDIVNGLLFLHSQSILHLDLKPANILISEKDVCKISDFGCSQKLQDLRCRPSLHHIGGTYTHQAPELLKGEIATPKADIYSFGITLWQMTTREVPYSGEPQYVQYAVVAYNLRPHWQAVFTASLTGKTLQNNVQSCWEARALQRPGAELLQKDLKAFRGALG
Protein: Leu/Val/Ile amino-acid permease (Branched-chain amino-acid permease 2) (P38084)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 3-isopropylmalate dehydrogenase
- SPS-sensor component PTR3
- Regulatory protein LEU3
- 2-isopropylmalate synthase
- 3-isopropylmalate dehydratase
- Acetolactate synthase catalytic subunit, mitochondrial
- Ketol-acid reductoisomerase, mitochondrial
- Peptide transporter PTR2
- Vacuolar amino acid transporter 5
Sequence:
MLSSEDFGSSGKKETSPDSISIRSFSAGNNFQSSSSEKTYSKQKSGSDKLIHRFADSFKRAEGSTTRTKQINENTSDLEDGVESITSDSKLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLHYGGPAALIIGYILVSFVTYFMIQAAGEMAVTYPTLPANFNAYSSIFISKSFGFATVWLYCFQWLTVLPLELITASMTIQFWNDKINPDIYILIFYVFLVFIHFFGVKAYGETEFIFNCCKILMIAGFIILSIVINCGGAGNDGYIGATYWHNPGAFAGDTSIGRFKNVCYILVTAYFSFGGMELFALSVQEQSNPRKSTPVAAKRSIYRIVVIYLLTMILIGFNVPYNDDQLMGAGGSATHASPYVLAASIHGVKIVPHIINAVILISVVSVANSSLYAGPRLICSLAQQGYAPKFLDYVDREGRPLRALIVCCVFGVIAFVAASSKEEIVFTWLAAIAGLSELFTWTSIMLSHLRFRQAMKVQGRSLDELGYKATTGIWGSIYGVFFNILVFVAQFWVALAPLGNGGKCDAESFFQNYLAFPIWLAFYFGYMVYNRDFTLLNPLDKIDLDFHRRIYDPELMRQEDEENKEKLRNMSLMRKAYHFWC
Protein: 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (Heat shock protein 60) (E7ESH4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITDGKTLNDELEIIEGMKFDRGYISPYFINTSK
Protein: Kinesin-like protein KIN-14G (Kinesin-like protein KatD) (O81635)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Microtubule-binding motor protein.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Probable serine/threonine-protein kinase CST
- At5g20110
- Pentatricopeptide repeat-containing protein At1g03540
- Kinesin-like protein KIN-10A
- Kinesin-like protein KIN-5A
- Cytochrome b561 and DOMON domain-containing protein At4g12980
- Kinesin-like protein KIN-5C
- Kinesin-like protein KIN-5B
- Protein SHI RELATED SEQUENCE 3
Sequence:
MATTSEINNDLSFSVVSIVEDVLQQHSSRSSDVGLVSRKVEESSLRRYEAAGWLRDMIGVSNGKDFPGEPSEEEFRLGLRSGIVLCNVLNKVNPGSVSKVVEAPDDVADGAALSAFQYFENIRNFLVAIEEMGLPSFEASDMEKGGKSIRIVNCILALKSYSEWKLKGENGPWRYGSNMKHNFGSRKLFLRKSSEPFVSSISRTQSTDMLSTDQPLSSDGDSRSINGLVRSFIADRKHEDIPNVVESVLNKVMEEVQQRLSIHNEMMKSSSKPIPEDDSSCETVVRSQLCDARQHEEAEENSPPQVVEKKFQRTNFEHHEEQKILLNQQKHIQELKQTLYTTKAGMKLLQMKYQEDFFHLGKHLNGLAYAATGYKRVLEENRKLYNLVQDLKGNIRVYCRVRPFLPGQESGGLSAVEDIDEGTITIRVPSKYGKAGQKPFMFNKVFGPSATQEEVFSDMQPLVRSVLDGYNVCIFAYGQTGSGKTFTMTGPKELTEESLGVNYRALADLFLLSNQRKDTTSYEISVQMLEIYNEQVRDLLAQDGQTKRLEIRNNSHNGINVPEASLVPVSSTDDVIQLMDLGHMNRAVSSTAMNDRSSRSHSCVTVHVQGRDLTSGSILHGSMHLVDLAGSERVDKSEVTGDRLKEAQHINKSLSALGDVISSLSQKTSHVPYRNSKLTQLLQDSLGGSAKTLMFVHISPEPDTLGETISTLKFAERVGSVELGAARVNKDNSEVKELKEQIANLKMALVRKGNGNDVQPTAIPINRERISRRRSLETPTIRPKLPTMGNTSNNSRPQIMDLSGPEAFNDSTASSRRHSLDIHELMKSSSPAWPRQPLNGKDEDRESKSGEWIDKHEELIQNQNPNSPEQFYQSMVPQQQSLYGGKQDFEVQSITDNESDEAATSDCSDSDLLWRLSVQVNVPKVSNIQNSANPKPKKIQPRTAKLSETRSLIPSLIPAPSKRPPNTVNSQPQRPTRDGKRRLSLGT
Protein: CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (CD antigen CD151) (O35566)
Organism: Mus musculus (Mouse)
Function: Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P48509}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48509}. Note=Relocalizes to the immune synapse in T-cells upon activation. {ECO:0000250|UniProtKB:P48509}.
Interaction partners:
- Integrin alpha-3
- Collagen alpha-1
- Gamma-aminobutyric acid receptor subunit alpha-6
- Dystonin
- Plectin
- Neuronal acetylcholine receptor subunit alpha-3
- Platelet glycoprotein V
- CD63 antigen
- Integrin beta-1
- CD81 antigen
Sequence:
MGEFNEKKATCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASSTYLATAYILVVAGVVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMVKRYHQSGHEGVSSAVDKLQQEFHCCGSNNSQDWQDSEWIRSGEADSRVVPDSCCKTMVAGCGKRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY
Protein: Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) (P9WFV5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Valine--tRNA ligase
- Threonine--tRNA ligase
- Arginine--tRNA ligase
- Uncharacterized protein Rv2581c
- Aspartate--tRNA
- ATP phosphoribosyltransferase
- Cysteine--tRNA ligase
- Tyrosine--tRNA ligase
- GMP synthase
- Glutamate--tRNA ligase
Sequence:
MTEFSSFSAPKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIELPIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGFRSLGLDGFRLEITSLGDESCRPQYRELLQEFLFGLDLDEDTRRRAGINPLRVLDDKRPELRAMTASAPVLLDHLSDVAKQHFDTVLAHLDALGVPYVINPRMVRGLDYYTKTAFEFVHDGLGAQSGIGGGGRYDGLMHQLGGQDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVPLGEAAKLRLAVLAGRLRAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTVAVKDLTTGEQVSVSMDSVVAEVISRLAG
Protein: Oxidized low density lipoprotein receptor 1 (F5H001)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYL
Protein: Protein kinase, putative (Q387N8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNRYTILGQLGDGSFGVVSKAQNTSTGEVVAVKKMKQRFSNWEECLQLREVQFLRKVHHPNIVKLREVVRENNELFLIFEYMEMNLFGIQRMRSEQMGGVQSIFNDREIRSIMCQTLLAVQAMHKNGFMHRDLKPENLLTKGDVVKVADFGLAKEIRSRPPFTEYVSTRWYRAPEIILRSTHYNSPVDIWACGVIFAELYLNRPLFPGSSGNDQLFKICSILGAPTTAEWDEGYQLLRRLNMRFPTVAPTPLRQLLAGAPPNAIDLMEQMLKFNPSDRLTATQCLRHPYFTGTGSAAEAGGTATAMYAGIATGQPHNPFHAAGAARRLSVSTTSFGGCEGASSAATLGRDRASSSTTLFFGGGPPGSDSAGSQLPPKPGLDDEAFNF
Protein: Inwardly rectifying K+ channel protein (Inwardly rectifying potassium channel 1, isoform D) (Q9VCQ0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
Interaction partners:
Sequence:
MYILLFRFRYRQTRFSSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDVDTPLCSAKQLDELKSEYSKSAKCVNAPFADRTLSASLFQRIASAASVDHLDPASDESLDSGRLQIRSHSIPNGVLASELEPLNNNKHGASFTMGGLTITTTAPSIPNLSSINEKTNSGNSINSSNYSNNNSLSTLTGGGSAASGPGGGITIVAGSGNHGGAGGGGGGGGRHKSNPRRLSIKQDQLPIDSIC
Protein: Insulin-degrading enzyme (EC 3.4.24.56) (Insulin protease) (Insulinase) (Insulysin) (P35559)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (By similarity). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia. Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (By similarity). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (By similarity). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10684867, ECO:0000269|PubMed:1836994}. Cell membrane {ECO:0000269|PubMed:10684867}. Secreted {ECO:0000269|PubMed:10684867}.
Interaction partners:
- Insulin-2
- Amyloid-beta precursor protein
- Islet amyloid polypeptide
- Insulin-1
- Membrane metallo-endopeptidase-like 1
- Neprilysin
- 26S proteasome regulatory subunit 6B
- Pro-glucagon
- Ubiquitin carboxyl-terminal hydrolase
- 26S proteasome regulatory subunit 8
Sequence:
MRNGLVWLLHPALPSTLHSILGARPPPVKRLCGFPKQIYSTMNNPAIQRIEDHIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILALEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQRRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL
Protein: Kallikrein 1-related peptidase-like b4 (7S nerve growth factor alpha chain) (Alpha-NGF) (P00757)
Organism: Mus musculus (Mouse)
Interaction partners:
- Beta-nerve growth factor
- Kallikrein 1-related peptidase b3
- High affinity nerve growth factor receptor
- Tumor necrosis factor receptor superfamily member 16
- Enamelin
- Amelogenin, X isoform
- Ameloblastin
- Amelotin
- Matrix metalloproteinase-20
- Hepatocyte growth factor receptor
Sequence:
MWFLILFLALSLGGIDAAPPVQSQVDCENSQPWHVAVYRFNKYQCGGVLLDRNWVLTAAHCYNDKYQVWLGKNNFLEDEPSDQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLSKPADITDVVKPITLPTEEPKLGSTCLASGWGSTTPIKFKYPDDLQCVNLKLLPNEDCDKAHEMKVTDAMLCAGEMDGGSYTCEHDSGGPLICDGILQGITSWGPEPCGEPTEPSVYTKLIKFSSWIRETMANNP