Protein: E3 ubiquitin-protein ligase hecd-1 (EC 2.3.2.26) (V6CLA2)
Organism: Caenorhabditis elegans
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the ubiquitination and proteasomal-mediated degradation of cytoplasmic and mitochondrial proteins. Positively regulates lin-12 activity in the anchor cell (AC)/vulval precursor (VU) cell fate decision. Negatively regulates glp-1 activity in germline proliferation. May play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci.
Interaction partners:
Sequence:
MDGIDPETLLEWLQTGIGDERDLQLMALEQLCMLLLMADNIDRCFESCPPRTFIPALCKIFIDETAPDNVLEVTARAITYYLDVSNECTRRITQVDGAVKAICTRLAAADISDRSSKDLAEQCVKLLEHVCQRETMAVYDAGGINAMLTLVRVHGTQVHKDTMHSAMSVVTRLCGKMEPTDPELGKCAESLGALLEHEDPKVSESALRCFAALTDRFVRKMMDPAELAMHSNLVEHLISIMVASNDENSPTTASANILSIVLSLIGNLCRGSSLITEKVLTSPNMITGLKATLTNKEERVVTDGLRFCDLLLVLLCEGRSALPLTSVVSGDYAAGSGAERVHRQLIDAIRQKDLTALVDAIESGQVDVNFADDVGQSLTNWASAFGSIEMVQYLCDKGSDVNKGHKSSSLHYAACFGRPDVVKLLLQRGANPDLRDEDGKTALDKARERSDDDHNQVANILESPSAFMRNKEDPKVKASTSKQPGTSTKPELPNPNLVRKVLHQLLPIFCEIFQKSLNGSVRRTSLSLMRKIVENIGDLRQSAVGDGNAPAAQSARKMSTDVSAGAESLVAVVVSVMDQEDDHEGHEQVLLILESLLEKDAELWVIELVRLGVFERVEAMAKEPPKGLEEVLNAIHLEGRSRVTPMEIDFENQPSSSTAVPTANDIMDTTVPSSSGGADAESNSNPSTIEMADPESSTPSSSTQQSISKPKATASSTASSAILQVVSKLSSVASLDKSAAAVDKKPTKTVLSQGTPYRWKEWRIVRGTTSLFIWSDVLLIELPFQSNGWFRYLADNDSHVQFVTGTASVDQQMTEEEKDNFQKTERREMVSRWNAVKGVFDDDWSSVPIAVLGIPSNAKKVSQKLEVPAWELWSSKSSELQIKSISSSAPTGQANTMLTTIKDDAGGFLFETGTGRKTNVMPEHALPSDFHTGWSSHGVSTRKMKFRQDIQKRKVQELAWKLWNDHLKEAHAKPREALVRLENAARTIESTIRHVKAQSNFKHRNVKQPRIERVQEYCAAISTLHESIVDDRRLSTFEFSVSGIVPALFGLLSMMEKFPDSFPSRIFKEQFSKGEALSYLALKIVAVLEANEKFPQHLYDSPGGSSFGLQLLSRRVRTKLEMLPRADGKENNDENLVNKTGKIVKCEPLASVGAIRAYLHRMVTRQWHDRERANYRYVKEIQELKTKGKSIELRHVSDFDENGVIYWIGTNGRAAPLWTNPATVKAVKITCSDTRQPFGKPEDLLSRDQNPINCHTSDDKNAHFTIDLGLFVVPTSYSLRHSRGYGRSALRNWMLQGSVDAKRWENVIVHTDDKGLGEPGSTATWHVGEKGTTAFRFFRIAQNGKNSSGQTHYLSCSGFEIYGDIVDVVTEAICEDPPKKDSPAGTSSTPGSSSSAALPPLTKEQVLEMLPARENNNRLKSGLSLETVTSMLQRSRHRSRGSYKISESKSKVVRGKDWRWEDQDGGEGKFGRITSPPESGWVDVTWDNGNANSYRFGANGNFDIERVTSTGHRYSTPSLASHVPTSVMEAVRRNRAFYTPKTTGGPPSSSVFGTSSSAGSSRGAASALSRFASVKNTTPAGTPSSGGSSGGAIGKKSMSTTNLVDERQKTSGPSVASTGQAASAESLQHQTPSLENLLARAMPHAFGRIAENQEPEDEPMGGEESDSAASMRSAASSNSQMSMGSSSQQQQQQDSDMTPRDSAGTPSTPRDDKNQTLSVSAPDLAAARQRQASAETDGDADADETNSEDKTVGADDAMEEDDEEEETMEDEEDDDDDDDDESSNENQEKLVELLGGERGLFDKLKEVITGESLSDASSSAKDATTNEAQKKGGKKPKKWFKKMSSYTDVLKGLMQNRYPVALLDPAAAGIEMDEMMDDDDYYDFSEDGPDDGDSVEDEVAAHLGMPVDSFASMVAARTPITWRQFSELMSGSNRERAAMARAVASSRGSPWEDDATVKCTFEALIPAFDPRPGRSNVNQTLEVELPTVVKDFGSTKASSSKIDKDDQMRFFLRGPNMSGVDNVTIEMNDDSASLFRYMQIINNSVNWATKSDRSRRIWEPTYSICYCSADQTNVEVSKIPDEESSTPCQVNQCLETIGLLSRIQQAMPEAEITPNVFISDKLTLKVTQVLSDALVVAARSLPEWCSRLVYKYPCLFTVETRNMYMQATAFGVSRTIVWLQQRRDAAVERARGSAQAGNSSAARQHDRYHEYRVGRLRHERVKVTRAEETLLDQAIRLMKFHADRKAVLEIEYTNEEGTGLGPTLEFYALVAAELQRKSLALWVCDDDDTHASKSGEEREVDLGEGKKPIGYYVRRVGGLFPAPLPPGTDETKRAADMFRVLGVFLAKVLLDGRLVDLPLSRPFLKLLVHPQIGDDARGPNLHKILSLDDFEEVNPVKGSFLKELRALAQRKRLIENDTSIDSNSKRRKIAELKLHIKGSTCRVEDLALNFTVNPPSKVFQYAEMELVDGGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFRDGFDRVFPLRTLRAYSPEEVQRLLSGEQCPEWSRDDILNYTEPKLGYTRESPGFLRFVDVMEALTAQERKNFLQFATGCSSLPPGGLANLHPRLTIVRKVESGDGSYPSVNTCVHYLKLPEYSSSAILRERLLTAINEKGFHLN