wanglab/gogpt-training-data huggingface dataset:
Protein: Myopic (Q9VUH6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endosome {ECO:0000256|ARBA:ARBA00004177}.
Interaction partners:
- Charged multivesicular body protein 4
- Jak pathway signal transduction adaptor molecule
- Growth factor receptor-bound protein 2
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- Transcriptional coactivator yorkie
- FI02822p
- Ras-related protein Rab5
- E3 ubiquitin-protein ligase Su
- Zinc finger FYVE domain-containing protein
- Vacuolar protein sorting-associated protein 28 homolog
Sequence:
MEAVPRLHMLWFALKSSPEGTSFAALKKYIAEFYHEDPEAYSKEVHALETLRNQAMHTTKDGAPVMKRYYCQLHALQNRFPQLADRGIFTFKWKDLYHSAVHEVTDLRFERAAVLFNIAALHTQSGASVTRGDVDGMKMACTHFQAAAWAYGELRERYANVNGGGDFMTPELLVFQQQVCFAQAQECILEKSLIDNRKPHIVAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVYKLWKKYVRFKINYLTCILYLYQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINESLSFTADVVEAKRKNAKNENEFIYHEAVPELSTIAAVQGANLVNGIGFQVSDEEHAGPDIFARLVPMKAHEASSLYSEEKAKLLRKYGALLEEKDTQLESYMSSLTLDNLNINEEQANKLPQGIVDRCAALNANKTAISDLVEAMSQLAEITADVETNLGEISSMLEAEAKAEREFQSATGVQRTPNAHITELSREFQKYSEAHARAGESNNTLRKAMSLHVNNLKILARPLPEIQQLMPKLSSELNTTEIFRDVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVIAHGGQEGLQALFATELGKHDKITELLDQNMVAQGNILQALTENYAKAAPVLKTLQDVKQKREHFYSSLAASYDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFRSARDVQSEERQQRMQSVKAATTPVVSKPIAETTPVPAVSSTPKLRDYLKAKAAMADASNPAYVPTVRPVPVGSENPTQAACSYATAPPNEPPPPYSLTQQQYFDPSAAGYTNPMYQQQQQHIAPPAYKAQASPNSQTLHGALGQMNLQGQSQDNNQAGMAYNYGYPSGSVPPLAYAPPGTVPASSASQGLNIQQPLYVATSGNPVSVSNPSELPSTLQAPFVVNPMSNPYQTAAGYSGQAYQQVNAQAQQVTYPTAPSGSSTGQSAQQPLGYAPSQGPQQQAGGYPQSQTPQQQVGAYQQQPLSGYAQQLTPQQQTGYSQSQAPQLQAPSYAQNQQSTGQAQQQQTGYPQTPQQHLAGYAQSQQQATGYPQSQTSQQQTTGYSQSQTPQQPLAYQQQPSGYPQQQQQQSLAPQQPSLYPSQAVQASPQPIPGQQATPPNAGQPLPYPQQYTDPNAAPAPAPGVSSVPSPVPVPTPAPTSSQAQVPTSPHPSATYTSYSNHPGYSFNPQTGKYEYSSGYQQDTSSLKGSQASQSYQFSQSGKQQSVGTTDSEIASRSNTATGFDSPIVSHTKVNMAAKDSTSAIEGNESSNYYSTPYGYLGSVNPQQQPTPAPPSNSTASIYMQSGASSTAETQTTSSGVPYASSAALTKVEPKPEALPPKVTSNVDLLSDLDIDCSVAVPPPMLPQPVLQPQVVATPTPPASQVSVPVKVESVAEHAAPATAEIPVAATEGTAQTPVTIPSGPKCASLDNLSNCSDLSSLENFDWDSVSVTHSVSEKQTKASATANGHSSSFAFQSETFTDEKTTKYFQKEVESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIGVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRGIMTSYQMKMAPQVTAKEQQENKDPLNELDALWKLK
Protein: RNA polymerase-associated protein LEO1 (Q6NYV9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development.
Subcellular location: Nucleus {ECO:0000269|PubMed:20178782}.
Interaction partners:
- FACT complex subunit
- Transcription elongation factor SPT5
- Transcription elongation factor SPT6
- RNA polymerase-associated protein CTR9 homolog
- RNA polymerase II-associated factor 1 homolog
- RTF1 homolog, Paf1/RNA polymerase II complex component.
- Parafibromin
- Transcription elongation factor SPT4
- FACT complex subunit SSRP1
- FACT complex subunit SSRP1
Sequence:
MADMDELFGSDGDSDNEQRDSGSGSGSDSDHERPRSASNASGSESAQSDRDHDDDEDEDGGKPSNKELFGDDSEDEHGSQHSGSQHSGSRHSGSRHSGSRHSGSRHSGSQHSGSQSERSGNQSDATMHSDNEHSMSEAHRGEQDDEDDDDRGHRSDVGSPASGAGSRRSDRGSGSPGSEAGSPRSEAGSGHSDPGTPHTDGEGSGKDAHSGDEKWGGDGKSDQSEDEDKQQNSDDERERSDEEGERQKSESIKGSDSEDDFTRKKKKKIASDSDSDSDAETQGGKKPAANDLFGEADDISSDSDAEKPLTPGQPLDADDGMEGDQPEEEPAPETRIEVEIPKVSTDLGSDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRSRRDEEGNEVKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPESQRNEMIKKEEERLRASIRRESQQRRMREKQHQRGLNAGYLEPDRYDEDEEGEESISLAAIKSKYKGGGGLREERARIYSSDSDEGSDEDKAQRLMKAKRLDSDEEGENSGKRKAEEDEESASKKPKKYVISDEEDEDGDGERDGDRERGGDMDGDGDGDMEGDGDVDRDGDMDGDGEGDGEGDGEEDE
Protein: CLAVATA3/ESR (CLE)-related protein 26 [Cleaved into: CLE26p] (O04547)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular location: [CLE26p]: Secreted, extracellular space {ECO:0000250|UniProtKB:O49519}.
Interaction partners:
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
Sequence:
MRNNHSLRLQLWFRTLFTVGVVTLLMIDAFVLQNNKEDDKTKEITTAVNMNNSDAKEIQQELEDGSRNDDLSYVASKRKVPRGPDPIHNRFLLLSRFILSLLTNPYPYLHICVLDVSV
Protein: Zinc finger protein 200 (P98182)
Organism: Homo sapiens (Human)
Function: Could have a role in spermatogenesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:39513743}.
Interaction partners:
- Olfactory receptor 1F1
Sequence:
MMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQLVLEHFLTFLPKPSLVQPSQKVKETLVIMKDVSSSLQNRVHPRPLVKLLPKGVQKEQETVSLYLKANPEELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLAVNGSNPEGEDPEREPVENEDYREKSSDDDEMDSSLVSQQPPDNQEKERLNTSIPQKRKMRNLLVTIENDTPLEELSKYVDISIIALTRNRRTRRWYTCPLCGKQFNESSYLISHQRTHTGEKPYDCNHCGKSFNHKTNLNKHERIHTGEKPYSCSQCGKNFRQNSHRSRHEGIHIREKIFKCPECGKTFPKNEEFVLHLQSHEAERPYGCKKCGRRFGRLSNCTRHEKTHSACKTRKQK
Protein: Large ribosomal subunit protein bL21m (39S ribosomal protein L21, mitochondrial) (L21mt) (MRP-L21) (Q9D1N9)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q7Z2W9}.
Interaction partners:
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein bL32m
- Large ribosomal subunit protein bL19m
- Elongation factor Tu, mitochondrial
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL18
Sequence:
MAAAIAASALPGAFGRLVSVCSRSILASQGSGSASLWSASRRFNSQSASYPQGYVPKTSLSSPPWQEVVLPDPVEETRHHAEVVKRVNELIATGQYGRLFAVVHFASHQWKVTAEDLILIENELDIKCGERIRLEKVLLVGADNFTLLGKPLLRKELVRVEATVIEKTESWPKINMKFRKRKNFRKKKIIVNPQTILRINTIEIAPRLL
Protein: Type II restriction enzyme AplI (R.AplI) (EC 3.1.21.4) (Endonuclease AplI) (Type-2 restriction enzyme AplI) (D4ZX34)
Organism: Arthrospira platensis (strain NIES-39 / UTEX 3086 / IAM M-135) (Spirulina platensis)
Function: A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-CTGCAG-3' and cleaves after A-5.
Interaction partners:
Sequence:
MSSNNPTPNLEQLMLEARQLMKDLGLPDKMQGDTPIFVLLVMLDMKPAKSWSEANNQKWGITPLMNKMRELGFKNLAPNTRENIRDDCVGQLVDAELATENPDKPRPKNSPKYCYQINQEVLYLVKKIGSADYPIALNNFLSNYQTIKHKYQAKRQSQRLNVKIAHNFSVSIAPGGQGVLIKSVLQDFCKYFNIDKVLYIDNTVDTARGYSPFIDENLINYLGIDIDKFKNSYDKPDIVLYKSDNKYLIIIEAVKTGGAINVERRDRLLSLFENVDVKLSFVNAFESFKELKRLTKEITRETHAWIMEFPDHMIHFNGDQYLFH
Protein: FYVE, RhoGEF and PH domain-containing protein 2 (Q8BY35)
Organism: Mus musculus (Mouse)
Function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.
Subcellular location: Cytoplasm {ECO:0000269|Ref.2}. Nucleus {ECO:0000269|Ref.2}. Early endosome {ECO:0000269|Ref.2}. Early endosome membrane {ECO:0000269|Ref.2}. Cell projection, ruffle membrane {ECO:0000269|Ref.2}. Cytoplasm, cytoskeleton {ECO:0000305|Ref.2}. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides.
Interaction partners:
Sequence:
MERACEKQDSVCNLVAVFENNRTPGEAPGSHSLEDQPHSPEHQLSLSPEPWEAPPVKEALKSEFRPVSRTYLSSLKNKLSSGAWRRSCQPGVSPGPETQEPEEKRVVRELLETEQAYVARLHLLDQVFFQELLREAGRSKAFPEDVVKLIFSNISSIYRFHAQFFLPELQRRVDDWAATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWMDKSQPFQEVVTRIQCSEASSSLTLQHHMLEPVQRIPRYELLLKEYVQKLPAQAPDLEDAQRALDMIFSAAQHSNAAIAEMERLQGLWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSDPMERYLVLFNNMLLYCVPRVLQVGAQFQVRTRIDVAGMKVRELTDAEFPHSFLVSGKQRTLELQARSRDEMVSWMQACQAAIDQVEKRSETFKAAVQGPQGDTQEPKPQVEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCAKCSDYRAELKYDSNRPNRVCLTCYTFLTGNVLPQGKEDKRRGILEKEASAAPEQSLVCSFLQLIGDKCSRSLPRSWCVIPRDDPLVLYVYAAPQDTKAHTSIPLLGYQVISGPQGDPRVFQLQQSGQQYTFKAESVELQGRWVTAIKRAASGRTPEGPDEEDVSD
Protein: Thioredoxin (Trx) (ATL-derived factor) (ADF) (P10639)
Organism: Mus musculus (Mouse)
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P10599}. Cytoplasm {ECO:0000250|UniProtKB:P10599}. Secreted {ECO:0000250|UniProtKB:P10599}. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Secreted by a leaderless secretory pathway. {ECO:0000250|UniProtKB:P10599}.
Interaction partners:
- Thioredoxin-interacting protein
- Mitogen-activated protein kinase kinase kinase 5
- Peroxiredoxin-2
- Thioredoxin reductase 1, cytoplasmic
- Thioredoxin, mitochondrial
- Peroxiredoxin-5, mitochondrial
- Peroxiredoxin-1
- Mitochondrial peptide methionine sulfoxide reductase
- Glutathione reductase, mitochondrial
- Glutathione peroxidase 1
Sequence:
MVKLIESKEAFQEALAAAGDKLVVVDFSATWCGPCKMIKPFFHSLCDKYSNVVFLEVDVDDCQDVAADCEVKCMPTFQFYKKGQKVGEFSGANKEKLEASITEYA
Protein: Phosphodiesterase (EC 3.1.4.-) (B5BM35)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MMIVGDTFGFYQLVLRKHSCRLRYILHQLNSGQLPLEDLKRNIEYAALVLETAYMDETRRICDEDDDLAEVTPETVPDEVREWLAATFTRQNAGKKRDKPKFKSVANAIRTGIFFEKLFRKQQVVQCPIPPEIAELMKEVCTWSFSPFQLNEVSEGHALKYVGFELFNRYGFMDRFKVPLTALENYLSALEVGYSKHNNPYHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTNNFHIQSQSQFAMLYNDRSVLENHHVSSCFRLMKEDDKNILTHLTRDEYKELRNMVIEIVLATDMSTHFMQIKTMKSMLSLPEGIDKNKALCLIVHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHTVHVADSQIGFIDFIVEPTMVVCGELLVKMVEPLVSLPPTDSLFPPSVDGGDDKSPSNALSPLPDLRNSSTSPSSIRRIPLNYAGKLDIPTPWMKFLHENKAHWKERAAKEEEERKIKEAAEAEAAAKQVEENKENGVTTN
Protein: Tachykinin-like peptide-VI (P.nigriventer tachykinin peptides VI) (PnTkP-VI) (U29-ctenitoxin-Pn1f) (U29-CNTX-Pn1f) (P86303)
Organism: Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Subcellular location: Secreted {ECO:0000269|PubMed:15573368}.
Interaction partners:
Sequence:
QKKDRFLGLM
Protein: Transcription factor Sp8 (Specificity protein 8) (Q8IXZ3)
Organism: Homo sapiens (Human)
Function: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Calretinin
- Dynein axonemal heavy chain 11
- Homeobox protein EMX2
Sequence:
MLAATCNKIGSPSPSPSSLSDSSSSFGKGFHPWKRSSSSSSASCNVVGSSLSSFGVSGASRNGGSSSAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGGSSAHSQDGSHQPVFISKVHTSVDGLQGIYPRVGMAHPYESWFKPSHPGLGAAGEVGSAGASSWWDVGAGWIDVQNPNSAAALPGSLHPAAGGLQTSLHSPLGGYNSDYSGLSHSAFSSGASSHLLSPAGQHLMDGFKPVLPGSYPDSAPSPLAGAGGSMLSAGPSAPLGGSPRSSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTHSGGGGGGGSAGSGSGGKKGSDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE
Protein: Histone deacetylase 4 (HD4) (EC 3.5.1.98) (Q6NZM9)
Organism: Mus musculus (Mouse)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
Subcellular location: Nucleus {ECO:0000269|PubMed:22318228}. Cytoplasm {ECO:0000269|PubMed:22318228}. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-245, Ser-465 and Ser-629 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation (By similarity). Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (PubMed:22318228). {ECO:0000250, ECO:0000269|PubMed:22318228}.
Interaction partners:
- Nuclear receptor corepressor 2
- Nuclear receptor corepressor 1
- Runt-related transcription factor 2
- Histone deacetylase 5
- Ankyrin repeat family A protein 2
- Paired amphipathic helix protein Sin3a
- Myocyte-specific enhancer factor 2C
- Heat shock protein HSP 90-alpha
- B-cell lymphoma 6 protein homolog
- Calcium/calmodulin-dependent protein kinase type IV
Sequence:
MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPTAVPMDLRLDHQFSLPLEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSASYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVATALKKRPLDVTDSACSSAPGSGPSSPNSSSGNVSTENGIAPTVPSAPAETSLAHRLVTREGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQDAERLALPALQQRILFPGTHLTPYLSTSPLERDGAAAHNPLLQHMVLLEQPPTQTPLVTGLGALPLHSQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLHLSKIISKPSEPPRQPESHPEETEEELREHQALLDEPYLDRLPGQKEPSLAGVQVKQEPIESEEEEAEATRETEPGQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGSHRPLSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSSLTSVFVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLEPPMGDAEYLAAFRTVVMPIANEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRLVLALEGGHDLTAICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMDIHSKYWRCLQRLSSTVGHSLIEAQKCEKEEAETVTAMASLSVGVKPAEKRSEEEPMEEEPPL
Protein: RRM domain-containing protein (Q38BL8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWKQDIGQWVERKGRKGWTKQPQVSPPQPCTYTSGPQRLPVRVGFVPEGFEEKGEHPAVFSTASAASHADQAAATPSYAGQQWVTVYGVLPTSILDVRESLDVMFGRTLMHKLPTRAAVPSGGLTSTSVVGHSSQQNWFYVKFEDPVAAARAVYQSPLIVSAPSTNNLYSSAVCGTESKVQDGRVNGASREEAVGIAWCTDELFLQEQLKQERLIKSLEGRREGSENNYCGETLLEEGGEGVLNTVGATPCGADRLQKASLTPFVEEGRPGLRSAASSRGLGSLIREALCSPWSARWTASPAHTHDRSDADTSGCGNTNTRGSSSPSSTTSTANTQVFHENGSDGLGGTVCKGASSESNRNGGVSPLTEATIPSCLLARGRRYHHDAEHQIRNAQPTLPLPGNYSVLCAFKADVTERGLFKRVIRGILYIPCRVKQLLVKGDERTINNNANFTESGEARFLLDVVSQGRKRRAMIRNRHYGAASRLHSVDDHSSGQVSTPVLAEWAPTRWHESSSLYSLFVILLLIIISRNVNYADMRHTFTRGRGEDVLQSSKKIVDRRDNPTGSSQQPFNEVVPNVLLIDRVHGSDKYRAKTL
Protein: B-lymphocyte antigen CD20 (B-cell differentiation antigen Ly-44) (Lymphocyte antigen 44) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) (P19437)
Organism: Mus musculus (Mouse)
Function: B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P11836}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P11836}. Cell membrane {ECO:0000250|UniProtKB:P11836}; Lipid-anchor {ECO:0000250|UniProtKB:P11836}. Note=Constitutively associated with membrane rafts. {ECO:0000250|UniProtKB:P11836}.
Interaction partners:
- B-lymphocyte antigen CD19
- B-cell receptor CD22
- B-cell antigen receptor complex-associated protein beta chain
- B-cell antigen receptor complex-associated protein alpha chain
- POU domain class 2-associating factor 1
- Complement receptor type 2
- Fc receptor-like A
- Marginal zone B- and B1-cell-specific protein
- B-cell scaffold protein with ankyrin repeats
- Monocyte differentiation antigen CD14
Sequence:
MSGPFPAEPTKGPLAMQPAPKVNLKRTSSLVGPTQSFFMRESKALGAVQIMNGLFHITLGGLLMIPTGVFAPICLSVWYPLWGGIMYIISGSLLAAAAEKTSRKSLVKAKVIMSSLSLFAAISGIILSIMDILNMTLSHFLKMRRLELIQTSKPYVDIYDCEPSNSSEKNSPSTQYCNSIQSVFLGILSAMLISAFFQKLVTAGIVENEWKRMCTRSKSNVVLLSAGEKNEQTIKMKEEIIELSGVSSQPKNEEEIEIIPVQEEEEEEAEINFPAPPQEQESLPVENEIAP
Protein: Uncharacterized protein HI_1546 (P44249)
Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Interaction partners:
- Protein RecA
Sequence:
MNNQTLATQYEMDFSYNPLPFFSDIEDNLKFNKKLDLNLYCIKRPKQTCFIHITNPNMLAWGIESGDMLVVEKNDDLYSGDLVVLEENNEFHVYEFMAHSGNYLFMALDSTTQNINTKRLVKFTYYRHRDQYDSSNETSR
Protein: High-affinity potassium transport protein (P12685)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: This protein is required for high-affinity potassium transport.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Outward-rectifier potassium channel TOK1 channel YORK)
- Na
- Low-affinity potassium transport protein
- Serine/threonine-protein phosphatase PP-Z1
- K
- Serine/threonine-protein kinase HAL5
- Sodium/potassium exporting P-type ATPase 1
- Serine/threonine-protein kinase HAL4/SAT4
- Phosphopantothenoylcysteine decarboxylase subunit SIS2
- Serine/threonine-protein phosphatase PP-Z2
Sequence:
MHFRRTMSRVPTLASLEIRYKKSFGHKFRDFIALCGHYFAPVKKYIFPSFIAVHYFYTISLTLITSILLYPIKNTRYIDTLFLAAGAVTQGGLNTVDINNLSLYQQIVLYIVCCISTPIAVHSCLAFVRLYWFERYFDGIRDSSRRNFKMRRTKTILERELTARTMTKNRTGTQRTSYPRKQAKTDDFQEKLFSGEMVNRDEQDSVHSDQNSHDISRDSSNNNTNHNGSSGSLDDFVKEDETDDNGEYQENNSYSTVGSSSNTVADESLNQKPKPSSLRFDEPHSKQRPARVPSEKFAKRRGSRDISPADMYRSIMMLQGKHEATAEDEGPPLVIGSPADGTRYKSNVNKLKKATGINGNKIKIRDKGNESNTDQNSVSSEANSTASVSDESSLHTNFGNKVPSLRTNTHRSNSGPIAITDNAETDKKHGPSIQFDITKPPRKISKRVSTFDDLNPKSSVLYRKKASKKYLMKHFPKARRIRQQIKRRLSTGSIEKNSSNNVSDRKPITDMDDDDDDDDNDGDNNEEYFADNESGDEDERVQQSEPHSDSELKSHQQQQEKHQLQQNLHRMYKTKSFDDNRSRAVPMERSRTIDMAEAKDLNELARTPDFQKMVYQNWKAHHRKKPNFRKRGWNNKIFEHGPYASDSDRNYPDNSNTGNSILHYAESILHHDGSHKNGSEEASSDSNENIYSTNGGSDHNGLNNYPTYNDDEEGYYGLHFDTDYDLDPRHDLSKGSGKTYLSWQPTIGRNSNFLGLTRAQKDELGGVEYRAIKLLCTILVVYYVGWHIVAFVMLVPWIILKKHYSEVVRDDGVSPTWWGFWTAMSAFNDLGLTLTPNSMMSFNKAVYPLIVMIWFIIIGNTGFPILLRCIIWIMFKISPDLSQMRESLGFLLDHPRRCFTLLFPKAATWWLLLTLAGLNITDWILFIILDFGSTVVKSLSKGYRVLVGLFQSVSTRTAGFSVVDLSQLHPSIQVSYMLMMYVSVLPLAISIRRTNVYEEQSLGLYGDMGGEPEDTDTEDDGNDEDDDEENESHEGQSSQRSSSNNNNNNNRKKKKKKKTENPNEISTKSFIGAHLRKQLSFDLWFLFLGLFIICICEGDKIKDVQEPNFNIFAILFEIVSAYGTVGLSLGYPDTNQSFSRQFTTLSKLVIIAMLIRGKNRGLPYSLDRAIILPSDRLEHIDHLEGMKLKRQARTNTEDPMTEHFKRSFTDVKHRWGALKRKTTHSRNPKRSSTTL
Protein: Type 3 secretion system chaperone PscE (Pseudomonas secretion protein E) (Type III export protein PscE) (Q9I317)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Chaperone of the type III secretion (T3S) injectisome that translocates effector toxins into host cells, facilitating the establishment and dissemination of infection. Prevents premature polymerization of PscF, along with PscG, within the cytoplasm. Required for type III secretion needle assembly. Also required for cytotoxicity by influencing PscF levels.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16115870}.
Interaction partners:
- Type 3 secretion system needle filament protein
- Type 3 secretion system chaperone PscG
- Type III inner-rod protein PscI
- Translocator outer membrane protein PopD
- Regulatory protein PcrH
- Type III export protein PscH
- Translocator protein PopB
- Type 3 secretion system secretin
- Lipoprotein
- Type III export apparatus protein
Sequence:
MMTALETRLSVADGTHAAALRQRLQAALAECRRELARGACPEHFQFLQQQARALEGGLGILSQLTED
Protein: CCHC-type domain-containing protein (Q582S3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRDMEVERQWNDEKSASIDWKDPDDVLCNHWTFLRIVDFHPLLAQYATTHLEDKEHWKAIFTNPARTDEQKEALQFWLQNGLLTLREKRWCRECRKEGHTKRQCTEAKVPKGGGVLEKFAAHRAEIERYRLMQERQWENDPVTLLAIKKGGAQVRDGRGGTRDVKVGGPHVWVQNNNERRDLEPFVEERRRGTIGRVDTEHNIGFVRVPDMGEVKFFVDRVDYGVREVAVGDAVTLKIDVSRDYPIAVDIRLETPHVTSEDVYKFIRRCKNATQPITVIKAVMTHTFEWPDMLRLLRDMPPAAFVDGVHTLVELTTFVGNREPIHIPLLQSFLVLLQRESKDGTIPAFFPSMVQSALEIGREILNEGDMATAVERWLEVANLIVLLRQHAPVAGDGVASVQTTLISLLNEGVKATRGSAGELPGSVLAVRKRKVDATLGRMQNMEGSRSTDILIPSASDFSIPPPHELSPFSPCNLPVNGSKVYDTTESFITDHCRMLQADTFEAVSRILPAACFNFPDYKPTEETVSDVQHARLYHSVRFMGRVVTKDRDIACCTSYILQVQPKSPKAQAPVNIPVGTTLCITTGLNRTVMEDDEIFWCSVTSLNKPLLSGNMVVVSPCDSSASFELLAEKLHRNESLNKMDCSLMLVTEVFMMGYKSIMKALHAFVGPLAMPLPMLSSLVSPEAAAHASANGITCKAKKPGELVAYIPPHCEFAFQSLIADVCDRFTLDKGQEEALRLFPSSDILLVQGPPGTGKSFIGCRLVEVYVRYKQLVSSGDILSTIDVEQLHSTSPQHMLPSIVGPVVVITYKNHALDEFLIDLLQSGLWDDERPRIAQHLVNEMGATKADLFPCGKRVVRIGGQSKEAALDAYNLNALLRTKTDKAMLNSLKERIYLMNQRLERLIKEIHYLESGRVPKSLFERWLTEEQRKHIKYEDRDEWLQGKQYVGKSERTANRTLYLQLLKTRVESALEEAQRSPRERTEGKPEDEKEGEEDGAAQLSVFQEMRRQEENRKFNDSLHTTYLSSEAMELAKNPPTCPEGVPEELLSLWSLDPVLRHEYYAYLIRKCISVKARDCLLIMDAISNVVTIRDHVVSELKLELLQGADVVGLTTTGCASNQNLLRSLRPTILIVEEAAEVLESQLLACMTDSLQQVVLIGDHFQLRPKVETFLYEKFNRLNMSLFERLSSRMRPICLREQRRMHPLISRLVRPFYGPNMLLDNKDLYKRPFVCTKGVLHTDAVPGLARRVFFWRHSQPESEAPGSRSKVNLLEAEMVLKLVAHLTTEGVHQKSITVITPYLAQLRLLRTTLRLHAFSDVCVSTVDLFQGDENDVVILSLVRTERLTEFLKMRNRMIVCCSRARFAMVMIGNDGLLEQSTHWKQVLDTLRDDQCVGDKLPVTRFLSPGEEVMMSAD
Protein: Proteasome subunit alpha type-6 (Q54XM7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- Proteasome subunit beta type-2
- Proteasome subunit beta type-6
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-5
- Proteasome subunit beta type-4
- Proteasome subunit beta type-3
- Proteasome subunit alpha type-7
- Proteasome subunit beta type-1
Sequence:
MSRSGTAGYDMSIIFSPQGKLYQIEYAFKAIKTGGLTSVGIRGKDCVVVATQKKIPDKLIDPKSVTSLYKLTDYIGCVQTGIVPDSKSQASRAIQECATFHHKFGYQIPPNVLAKRMADIAQLSTQHASARPLGVAMILIGIDDELGPQLFKVDPAGVFTGYKATAAGEKEQESTNFLEKKFKSNPQLSKDETIQVSLIVMAISTLQSVLGADLKSSDLEIGICTMDNRKFVIMTDEDIDSQLTKLAERD
Protein: SPEE_NEUCR Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)Spermidine synthase (G5EAU1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- S-adenosylmethionine decarboxylase
- Ornithine decarboxylase
- agmatinase
- agmatinase
- Hypothetical arginase family protein
- Arginase
- Saccharopine dehydrogenase [NADP
- Hypothetical arginase family protein
- S-adenosylmethionine synthase
- Amine oxidase
Sequence:
MSEITHPTIKDGWFSEQSEMWPGQAMNLRVNQILHHEKSKYQDVLVFESSDYGTVLVLDNVIQCTERDEFSYQEMITHLAMNSHPNPKKVLVIGGGDGGVLREVVKHETVEEAILCDIDEAVIRVSKKYLPGMSIGFQHPNVKVHVGDGFEFLKQRQNEFDVIITDSSDPEGPAESLFQKPYFELLRDALRDGGVITTQAENQWLHLPLIADLKKACNEVFPVAEYAYTTIPTYPSGQIGFMVCCKDANRNVKEPVRTWSREEEERLCRYYNQDIHRASFVLPNFARKALGN