Protein: Glutamate receptor 1 (P34299)
Organism: Caenorhabditis elegans
Function: Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes omega turns, a movement that frequently follows backwards locomotion or 'reversals' in response to environmental cues while possibly playing an inhibitory role in alternative neurons to inhibit omega turns.
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:12123612, ECO:0000269|PubMed:24356955}; Multi-pass membrane protein {ECO:0000269|PubMed:12123612, ECO:0000269|PubMed:24356955}. Endoplasmic reticulum {ECO:0000269|PubMed:24094107}. Synapse {ECO:0000269|PubMed:17671168}. Cell membrane {ECO:0000269|PubMed:17671168, ECO:0000269|PubMed:22252129}. Recycling endosome {ECO:0000269|PubMed:17671168, ECO:0000269|PubMed:22252129}. Cell projection, dendrite {ECO:0000269|PubMed:22213799}. Perikaryon {ECO:0000269|PubMed:22213799}. Note=Partially co-localizes with lin-10 at synapses (PubMed:17671168). Trafficking between the plasma membrane and recycling endosomes in the ventral nerve cord is regulated by lin-10 (PubMed:17671168, PubMed:22252129). During hypoxia, accumulates in enlarged endosome-like compartments (PubMed:22252129). Co-localizes with rab-6.2 at or near punctate structures in the neuron cell body and along the ventral cord dendrites (PubMed:22213799). {ECO:0000269|PubMed:17671168, ECO:0000269|PubMed:22213799, ECO:0000269|PubMed:22252129}.
Interaction partners:
- Protein cornichon homolog 1
- Suppressor of lurcher protein 1
- STarGazin
- Glutamate receptor 2
- CUB domain-containing protein
- Ubiquitin carboxyl-terminal hydrolase 46
- Probable vesicular glutamate transporter eat-4
- Protein lin-10
- STarGazin
- GLutamate Receptor family
Sequence:
MFSSFSFLNMFGVLFTVFNLTVVQPYPSHIIIKSFGNNEEVSRVALKAMEYTSDHINSRDDVPFKLAFDHRVVEEGAAVSWNMVNAVCDELKEGAMALLSSVDGKGREGIRGVSDALEMPLVSLTALSNDDHQQQQFGNLFEVSVRPPISELLADFIVHKGWGEVLVLIDPVHASLHLPSLWRHLRTRTNTSVKASMFDLPADEKQFEAYLMQFNMMRNNETNRILIDCASPKRLKKLLINIRSAQFNQANYHYVLANYDFLPYDQEMFQNGNINISGFNIINKDGREYWSLKKHLKTSSSLGGGDDVSVEAAVGHDAMLVTWHGFAKCLQANDSLFHGTFRHRRFFNRGFPGIYCDPLSDRSHPNRPFSSFEHGKTIGVAFRNMKIGHKEGTLTGNIEFDRFGNRKNFDVSIVDLVSNTKATFNSKEVLAWRQGVGFFSNRTVAQHSRKSQNDHKDNQVIVLTNLVAPFVMIKRECLEMANLTECQGNNKFEGFCIDLLKLLADKIEEFNYEIKLGTKAGSKQADGSWDGMIGELLSGRAHAVVASLTINQERERVVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPYEWRVEETSRGGFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSSYTANLAAFLTLEKMQAPIESVEDLAKQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPPVFVASYAEGIERVRSHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGSDWKDHINLAILALQERGELKKLENKWWYDRGQCDAGITVDGSSASLNLSKVAGIFYILMGGMVISMLAALGEFLYRSRIEARKSNSNSMVANFAKNLKSALSSQLRLSVEGGAVAQPGSQSHNAIRRQQVAAFLPANEKEAFNNVDRPANTLYNTAV