wanglab/gogpt-training-data huggingface dataset:
Protein: C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) (P30993)
Organism: Mus musculus (Mouse)
Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P21730}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21730}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P21730}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000250|UniProtKB:P21730}.
Interaction partners:
- Complement C5
- Small ribosomal subunit protein eS19
- C3a anaphylatoxin chemotactic receptor
- Complement C3
- Integrin alpha-M
- C-C chemokine receptor type 5
- Toll-like receptor 2
Sequence:
MDPIDNSSFEINYDHYGTMDPNIPADGIHLPKRQPGDVAALIIYSVVFLVGVPGNALVVWVTAFEARRAVNAIWFLNLAVADLLSCLALPVLFTTVLNHNYWYFDATACIVLPSLILLNMYASILLLATISADRFLLVFKPIWCQKVRGTGLAWMACGVAWVLALLLTIPSFVYREAYKDFYSEHTVCGINYGGGSFPKEKAVAILRLMVGFVLPLLTLNICYTFLLLRTWSRKATRSTKTLKVVMAVVICFFIFWLPYQVTGVMIAWLPPSSPTLKRVEKLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLLRSLPSIIRNALSEDSVGRDSKTFTPSTTDTSTRKSQAV
Protein: Flavohemoprotein (EC 1.14.12.17) (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (Q2UDH4)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
Sequence:
MLAKTMFLSRVVPRLTPKALLLTRPFTTTTPKNKLTPQQIQIVKSTIPALQDHGVAITTLFYQRLLQQHPQLKNIFNTAHQATGEQPAALAHAVWAYATNIEHPEALKTAISRIGHKHASLGITADQYPIVGEGLLAAIKEVLGDAANDQVLDAWKAAYGELAGYFIDFESGLYRQAEATPGGWKGWRKFFISKKVHEGEEIISFYLTPVDKGALPAYKPGQFVSVKCFVPELGVYQPRQYSLSDVPNGEYFQISVKREFGLGQKPAGRISNVLHEGLPVGAELDVSMPFGDFVLDVNATTPVVLISGGVGLTPMMSMLKTIVDQGGSRRVVFIHAVRNGRVHAMKDRLAKIISENPQVQRAVFYEEVSKKDKQGVDYDFKGRADLHKIKDQVVLPDADYYICGPKLFMNAQSNSLKDMGVKEDRIHMEVFGSPAE
Protein: Homeobox protein YOX1 (P34161)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional repressor required to restrict transcription of ECB-dependent genes to the G1/M phase by repressing their transcription during the interval from late G1 to M phases. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. In vitro, is capable of binding to the DNA of the leucine tRNA gene.
Subcellular location: Nucleus.
Interaction partners:
- Pheromone receptor transcription factor
- Homeobox protein YHP1
- Forkhead transcription factor HCM1
- Fork head protein homolog 1
- Cyclin-dependent kinase 1
- Fork head protein homolog 2
- G1-specific transcriptional repressor WHI5
- Regulatory protein SWI4
- Transcription factor NRM1
- Transcription factor MBP1
Sequence:
MSQETKMLPSLSSLLSGTEISSSPVSPSFTNPRTSFHLDDRGTIKLPPLNTSINRPRSVESALRHTVTSLHENSSAYGDDMLKHTQSDSALSSQLNSSQETVDESHENLLLTPLNSKKRDYSVSSKKNDILTPLSAAKSIIIPSASKEKRRAFAFITHSQETFPKKEPKIDNAPLARRKRRRTSSQELSILQAEFEKCPAPSKEKRIELAESCHMTEKAVQIWFQNKRQAVKRQRIATSKSTTIIQTVSPPSPPLDVHATPLASRVKADILRDGSSCSRSSSSSPLENTPPRPHHSLNRRSSTPSIKRSQALTFHLNPQKKTLTPVKTSPNSRVNKLINSIDHSPSKAKRPVSNPSGSPKRKRKFGFKIVDQQPLKDLDPNAFRG
Protein: Proton-coupled folate transporter (Solute carrier family 46 member 1) (F1NJ67)
Organism: Gallus gallus (Chicken)
Function: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force. Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus. Functions at acidic pH via alternate outward- and inward-open conformation states. Protonation of residues in the outward open state primes the protein for transport. Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate. Also able to transport antifolate drugs, such as methotrexate and pemetrexed. Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000269|PubMed:34040256}. Apical cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000269|PubMed:34040256}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q6PEM8}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity). Localizes to the basolateral membrane of choroid plexus (By similarity). {ECO:0000250|UniProtKB:Q6PEM8}.
Interaction partners:
- Reduced folate transporter
- Dihydrofolate reductase
- MFS domain-containing protein.
- Major facilitator superfamily domain containing 9.
Sequence:
MAAPSDPPTAATPPAPPPPARRCLLAPSVEPLLFLATLALGLQVPLATQYLWDRLGAERGYVGPNASSPHGCGNGSGAVDPLREEVEALVAHWNLCINLGGFFVGLFSVTLFGPWSDSVGRRPVLVLPAVGMAVQAAVYLLVMYLRLHVAYLLLGRIISGLLGDYNLILAGCFASVADSSNQRTRTFRVAILEACLGVAGMVASVGGGQWRKAEGYINPFWLVLAASLAAALYAALCLQETVKQRRAAKLLTLQHYKAVYKLYTAPEDLSSRRKLALYSLAFFLLVTVHFGTKDLYVLYELGSPLCWASDLIGYGSAASYLAYLSSLGGLRLLQLCLEDTWVAEIGLISNIAGLVVISLATTTPLMFTGYGIMFLSMAATPVIRAKLSKLVGETEQGALFASVACVEGLCSLVATGVFNSLYPSTLHFMRGFPFLFGAILLLIPAAIMGWIEIQDSNLQYSHFSDASSSPADG
Protein: DEAD-box ATP-dependent RNA helicase 26 (EC 3.6.4.13) (Q9FNM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- Pescadillo homolog
- Ribosome biogenesis protein WDR12 homolog
- AT5g04600/T32M21_200
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH3
- Probable rRNA-processing protein EBP2 homolog
- Transducin/WD40 repeat-like superfamily protein
- Ribosome assembly factor mrt4
- KRR1 small subunit processome component
Sequence:
MSSKFPLGVRFITHSLPCTRLASMNSGALIYSFRSVPVLSKAFPFRLKYIGLGSRVNFSTRPERSQPEFARRSGAGGEIRASKSLIEDEAELSDWVSDLRTSSLRGKFTSDEDNADPEVVRRNVDRDTSRGPRRGREGQSDRFGGAKRGKEGEMDRFGSPNRRRTSGEPADSFGNKRLGDREGSRNGRVQGKSSESSFRGRSDRNVDSGSSFRGRSDKNVDSGSSFRGRNDRNVDSGSSFRGRSDRNVDSGSSFRGRSDRNVDSGSSFRGRNDRNVDSGSSFRGRNDRNVESGFRREPGSENNRGLGKQTRGLSLEEEDSSDDDENRVGLGNIDDLPSEDSSDEDDENDEPLIKKAASAKAVQTDKPTGEHVKTSDSYLSKTRFDQFPLSPLSLKAIKDAGFETMTVVQEATLPIILQGKDVLAKAKTGTGKTVAFLLPAIEAVIKSPPASRDSRQPPIIVLVVCPTRELASQAAAEANTLLKYHPSIGVQVVIGGTKLPTEQRRMQTNPCQILVATPGRLKDHIENTSGFATRLMGVKVLVLDEADHLLDMGFRRDIERIIAAVPKQRQTFLFSATVPEEVRQICHVALKRDHEFINCVQEGSGETHQKVTQMYMIASLDRHFSLLHVLLKEHIADNVDYKVIIFCTTAMVTRLVADLLSQLSLNVREIHSRKPQSYRTRVSDEFRKSKAIILVTSDVSARGVDYPDVSLVVQMGLPSDREQYIHRLGRTGRKGKEGEGVLLLAPWEEYFMSSVKDLPITKSPLPPIDPEAVKRVQKGLSQVEMKNKEAAYQAWLGYYKSQKMIARDTTRLVELANEFSRSMGLDSPPAIPKNVLGKMGLKNVPGLRTK
Protein: Telomere length regulator protein rif1 (Q96UP3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Negatively regulates telomere length. Appears to play no role in transcriptional silencing of telomeric loci.
Subcellular location: Nucleus {ECO:0000269|PubMed:11676925}. Chromosome, telomere {ECO:0000269|PubMed:11676925}. Note=Localized to telomeres. This interaction may be increased by perturbation of telomere structure, for instance by loss of the rap1 protein.
Interaction partners:
- Telomere length regulator taz1
- Cell cycle serine/threonine-protein kinase hsk1
Sequence:
MTKEIAVKEASNMLLQEPSTPSSQAVGLSSSPSSSIRKKKVNFSSELENSPGGNRPSFGLPKRGILKTSTPLSSIKQPNFQSFEGNESEKETSLQELQSSFCSGIENLQHVEKSARIETYSKLSSFLKIYTPSLPEDPIFPLLNQLCNFLLSDRCSNNSEGSPDFQLNTQANKLLSILLWHPTISSHIQPETATVFIEQSLNFLEGPKLTKALAAQHLHLLSCQKCPLSIHPLCNRILDVCFNISFPSLVIGQERLAVLTKILSQFPLEFSRRVVDWAPYLLACLVDASRPIREKALLLALDLSKHLYHDKLVARTILANFRSDIKGTAFVLIMTEQFEKLVIEEDDGVYVAHAWAAIISVLGGARISSWEYFNTWLKIIQLCFNSMNPLTKCAAQTSWIRLIHEFSLSETLTQATKRLTLLCQPISMVLGSRNLPTVKNAAMTTLIALIYACLRPGISDAMLSLLWDSVIVNILEKCALKNEVTIFESSNILLALFNTLSNGVWKDDRLVCRESVEAKELPKLNPVWVRANCSRTIEPVKTLLLLAKPDHTVKTTTPARKQHIRGLSYEQSSSVWSTYIKCLASAGQKEIKRSVETGRAICCICSSLHKFLYSKSIRKDELYVERVSRFALMVKSAIEAFGINTFVEASYLVSDNQLVLIDQTKAIDSYDHVPISPLIYLLHSLALLTNGTLFSTVHAAYSSILSSIEEYHLRFGLKLMLLWDCVSPLSDDGTLVLARVLVSHEVSRLTSEALLSELKSRNGNNSVEEGFSEEERSILLKLLSWNVKFCSISDAGSVNNLLQQYFTAIYKFEGCGSVFPFVVDPFTTILDDVLSFEANKVYSFAISLMKVSTFESCTKELPPVTLPENIRQHLDSYNHMVELYNTLLQRLSSSDQVDLQCRYLHELSEFIKKIPKEFIFHTICKLSKGLIPCFLMNAFPQLEKSTTLQKSCTNFCILILQLLLNSTATASNILESLSPLLTSGLKSISKEVVLAAIKFWNQVFGKFESEEYPIELQKTISYLSKTYIILLPFQSLCPGGKQANHQSSEKMSDILKGVDELRSVSKNGPYASSQDKGEKTTEFSGPGKPNNDNYIQIASVQELDDSSKGKAGKMPASKKNKRQKGDVKKIDETKNEATDMEESLTTPSGKVNKEVIVDDTSLRDEAIVPDKAIDVADNSNALLKENISSQSNRKADNNGTPSVNNSFTTANNDECSKENSQIEPEGQTASREGVLSTPRSTRKKRKLGRKSQSSNVNKEVAISEVSATLENVEVIERHGISEQGQNLDESACVLTNESSLSQTEIPEEKTENETTAVNGFENSKKRQFSSLLSGSIDTNNESNKVSSVEFDKSGPQDIIQSMTEATFEIEKNIQDLKSEEVQKLSDLLMRLQRAILSRIA
Protein: Lipocalin Cav p 3.0101 (allergen Cav p 3.0101) (F0UZ12)
Organism: Cavia porcellus (Guinea pig)
Subcellular location: Secreted {ECO:0000305|PubMed:21518038}.
Interaction partners:
Sequence:
MQILLLALTIGLAYAHQTLDPSEINGQWHTISIAADNVEKIGEGGPLRGYFHNLHCYDGCKNIGLTFYVKLDGNCQRFDVLGAKQEDSDVYVAQYSGTNHFEVIGKKEDAIAFYNHNTDETGKETKMIVVVARRDSLTEEEQQKLQEVAGEKGIPKDNIRYFRERDTCAQ
Protein: Large ribosomal subunit protein uL3B (60S ribosomal protein L3-B) (SP-L1) (P36584)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein uL4B
- Large ribosomal subunit protein uL18A
- Elongation factor 3
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL8
- mRNA export factor elf1
- Large ribosomal subunit protein eL14
Sequence:
MSHCKFEQPRHGSLGFLPRKRASRQRGKVKAFPKDDASKPVHLTAFLGYKAGMTHIVRDLDRPGSKMHKREILEAVTIIETPPMVVVGVVGYVETPRGLRSLTTVWAEHLSEEVKRRFYKNWFKSKKKAFTKYAKKYAESTQSINRELERIKKYCSVVRVLAHTQIRKTPLAQKKAHLMEIQVNGGSVADKVEWAREHFEKTVDIKSTFEQNEMIDVIGVTRGKGNEGTTARWGTKRLPRKTHRGLRKVACIGAWHPANVQWTVARAGNAGYMHRTQLNSKIYRIGAGDDAKNASTDFDATEKRITPMGGFVRYGVVENDFVMLNGATPGPVKRVLTLRKSLLTHTSRKALEPVSLKWIDTASKFGHGRFQTPAEAKQFLGTLKKDVA
Protein: Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) (P24821)
Organism: Homo sapiens (Human)
Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Syndecan-4
- Integrin alpha-9
- Integrin alpha-V
- Integrin beta-1
- Integrin beta-3
- Syndecan-1
- Integrin alpha-8
- Integrin beta-6
- CD40 ligand
- Aggrecan core protein
Sequence:
MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA
Protein: Bifunctional IPC transferase and DIPP synthase [Includes: 1L-myo-inositol-1-phosphate cytidylyltransferase (IPCT) (EC 2.7.7.74); CDP-L-myo-inositol myo-inositolphosphotransferase (DIPP synthase) (EC 2.7.8.34) (Di-myo-inositol-1,3'-phosphate-1'-phosphate synthase)] (Q8U1Z6)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments. Catalyzes the condensation of CTP and L-myo-inositol-1-phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di-myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Myo-inositol-1-phosphate synthase
- Fructose-1,6-bisphosphatase
- Methyltransferase domain-containing protein
Sequence:
MNILGGEEVKGVILAAGYGSRMGEKPKGLLKIAGREILYRTIKNLEKNGIKEFIIVTNERYLQKFEEFVKENNLQNVKLAVNRFPEKGNGYSLYVAKDFVKGKFVLVMSDHIYEEKFYELALRGEGLIVDRNPKFVDIDEATKVKIENDRVVDIGKEIPSWDGVDTGFFILDDSIFSVIEDILKEKEVVELKDVVKRARLKVSYVDGLYWMDVDTPGDLKKARKLIVYSSVKGVGDGFISRYINRKISTRISALLVDHITPNKLTIVTFLFGIFSGLMNLISVPLAAILYQISSIFDGVDGEIARARMQTSKFGGFFDSILDRYVDFTYLLTLAYVTIREPIWWVIAGIAIFSSAMVSYSTERFRGAYCADAYKVVPALRKIPGKRDERIFVTMIFALLGLIKPLFALLAAWSTLRVIITIYLVWRDVNG
Protein: Zinc finger CCCH domain-containing protein 20 (AtC3H20) (O82199)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370
- At5g05790
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
Sequence:
MMIGESHRGFNPTVHIPPWPLSEDLTVSDIYGSPDGGSSMMEALAELQRYLPSNEPDPDSDPDLSGPDSPIDAYTCDHFRMYEFKVRRCARGRSHDWTECPYAHPGEKARRRDPRKFHYSGTACPEFRKGCCKRGDACEFSHGVFECWLHPARYRTQPCKDGGNCRRRVCFFAHSPDQIRVLPNQSPDRVDSFDVLSPTIRRAFQFSISPSSNSPPVSPRGDSDSSCSLLSRSLGSNLGNDVVASLRNLQLNKVKSSLSSSYNNQIGGYGSGFGSPRGSVLGPGFRSLPTTPTRPGFMNIWENGLEEEPAMERVESGRELRAQLFEKLSKENCMGRIEPDPDQGAGDTPDVGWVSDLVM
Protein: Protein ABERRANT PANICLE ORGANIZATION 1 (F-box protein 321) (OsFbox321) (Protein STRONG CULM 2) (B8B183)
Organism: Oryza sativa subsp. indica (Rice)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Together with FL/APO2, involved in the temporal regulation of meristem identity during both vegetative and reproductive developments in an APO2-dependent manner (By similarity). Promotes spikelet formation by suppressing the precocious conversion of inflorescence meristems to spikelet meristems, probably via a positive regulation of class-C floral homeotic genes, but not of class-B genes, and through the control of cell proliferation in meristems. Mediates culm development and strength/diameter enhancement at internodes. Required for the regulation of the plastochron, floral organ identity, and floral determinacy (By similarity). Controls the number of primary rachis branches (PRBs). May trigger the formation of vascular bundle systems which, consequently, promote carbohydrate translocation to panicles. Involved in ozone-induced grain yield regulation.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MMNPRRLPPLPSSTSSASAADDMDPRVWRRLPQPLVDRVLACLPTPSFLRLRAACRRFYHLLFSSPFLHSHLLLSPHLPFFAFVVPAAGHLLLLDPTATASWSRLPLPLPPVAGGPAAFSPAAASAGLLAFLSDASGHKTLLLANPITRLLAALPISPTPRLSPTVGLAAGPTSIIAVVAGDDLVSPFAVKNISADTFVADAASVPPSGFWAPSSLLPRLSSLDPGAGMAFASGRFYCMSSSPFAVLVFDVAENVWSKVQPPMRRFLRSPALVELGGGREGAARVALVSAVEKSRLSVPRSVRLWTLRGGGGGGGGGAWTEVARMPPEVHAQFAAAEGGRGFECAAHGDYVVLAPRGPVAQAPTSALVFDSRRDEWRWAPPCPYVVVAHHGGAGAAGFRVFAYEPRLATPAIGLLDATAPVALHGMHDG
Protein: RE68961p (Q8IGL4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLGEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPACSTTFMDYEDSDAPHPDGSNNGERNAHTPQNTYGSGSPHYPGTASNMQFHTSYGMSGCNNCDSEMDIKPYIPAEHHSFQIPAIRSEELVNPNCPWSRMQERFRRTPPASFTDDERNANDMRHKLKKAQKECLFSTAAKVFHHHIEGRLRKLTSAAT
Protein: B3 domain-containing protein VP1 (OsVP1) (Protein viviparous homolog) (P37398)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor that may participate in abscisic acid-regulated gene expression during seed development. May be required for seed maturation and dormancy induction.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00326, ECO:0000269|PubMed:11917085}.
Interaction partners:
- bZIP transcription factor ABI5 homolog
- bZIP transcription factor TRAB1
- Ethylene-responsive transcription factor ABI4
Sequence:
MDASAGSSAPHSHGNPGKQGGGGGGGGGRGKAPAAEIRGEAARDDVFFADDTFPLLPDFPCLSSPSSSTFSSSSSSNSSSAFTTAAGGGCGGEPSEPASAADGFGELADIDQLLDLASLSVPWEAEQPLFPDDVGMMIEDAMSGQPHQADDCTGDGDTKAVMEAAGGGDDAGDACMEGSDAPDDLPAFFMEWLTSNREYISADDLRSIRLRRSTIEAAAARLGGGRQGTMQLLKLILTWVQNHHLQKKRPRTAIDDGAASSDPQLPSPGANPGYEFPSGGQEMGSAAATSWMPYQAFTPPAAYGGDAMYPGAAGPFPFQQSCSKSSVVVSSQPFSPPTAAAAGDMHASGGGNMAWPQQFAPFPVSSTSSYTMPSVVPPPFTAGFPGQYSGGHAMCSPRLAGVEPSSTKEARKKRMARQRRLSCLQQQRSQQLNLSQIHISGHPQEPSPRAAHSAPVTPSSAGCRSWGIWPPAAQIIQNPLSNKPNPPPATSKQPKPSPEKPKPKPQAAATAGAESLQRSTASEKRQAKTDKNLRFLLQKVLKQSDVGSLGRIVLPKEAEVHLPELKTRDGVSIPMEDIGTSQVWNMRYRFWPNNKSRMYLLENTGDFVRSNELQEGDFIVIYSDIKSGKYLIRGVKVRRAAQEQGNSSGAVGKHKHGSPEKPGVSSNTKAAGAEDGTGGDDSAEAAAAAAAGKADGGGCKGKSPHGVRRSRQEAAAAASMSQMAVSI
Protein: NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) (NADH dehydrogenase subunit 5) (P03920)
Organism: Bos taurus (Bovine)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:17060615}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase 1 beta subcomplex subunit 6
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- Cytochrome c oxidase subunit 2
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 8
Sequence:
MNMFSSLSLVTLLLLTMPIMMMSFNTYKPSNYPLYVKTAISYAFITSMIPTMMFIHSGQELIISNWHWLTIQTLKLSLSFKMDYFSMMFIPVALFVTWSIMEFSMWYMYSDPNINKFFKYLLLFLITMLILVTANNLFQLFIGWEGVGIMSFLLIGWWYGRADANTAALQAILYNRIGDIGFILAMAWFLTNLNTWDLQQIFMLNPSDSNMPLIGLALAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFYPLTENNKYIQSITLCLGAITTLFTAMCALTQNDIKKIIAFSTSSQLGLMMVTIGINQPYLAFLHICTHAFFKAMLFMCSGSIIHSLNDEQDIRKMGGLFKAMPFTTTALIVGSLALTGMPFLTGFYSKDLIIEAANTSYTNAWALLMTLIATSFTAIYSTRIIFFALLGQPRFPTLVNINENNPLLINSIKRLLIGSLFAGYIISNNIPPTTIPQMTMPYYLKTTALIVTILGFILALEISNMTKNLKYHYPSNAFKFSTLLGYFPTIMHRLAPYMNLSMSQKSASSLLDLIWLEAILPKTISLAQMKASTLVTNQKGLIKLYFLSFLITILISMILFNFHE
Protein: Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (IMPDH-II) (P24547)
Organism: Mus musculus (Mouse)
Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P12268}. Nucleus {ECO:0000250|UniProtKB:P12268}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P12268}. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion. {ECO:0000250|UniProtKB:P12268}.
Interaction partners:
- GMP synthase
- Adenylosuccinate synthetase isozyme 2
- Adenylosuccinate synthetase isozyme 1
- Bifunctional purine biosynthesis protein ATIC
- Inosine-5'-monophosphate dehydrogenase 1
- AMP deaminase 2
- AMP deaminase 3
- AMP deaminase 1
- Hypoxanthine-guanine phosphoribosyltransferase
- Inosine triphosphate pyrophosphatase
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
Protein: Zinc finger protein 488 (Q5HZG9)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury.
Subcellular location: Nucleus {ECO:0000269|PubMed:16908628}.
Interaction partners:
- Olfactory receptor family 51 subfamily AB member 3
- Oligodendrocyte transcription factor 2
Sequence:
MAAGTSTLLSLSGPADHMAEGKGAPLRPSVEKRWKLMEPKQTQAGMFKKMSLVDSDTAAGKGSQDEAYTELSLPTAPNKPRLDRPRACKAYTEQRHNTFTELSCLQERPGDIQAQTRKLENPEGQLGPQQLPSSFLRASGDGTVCSAWPGAPRSEQKSAFSKPAKRPAEKPKRSPMLLAGGSAEGSWELSGLITTVDIPYWAHLSTFKFMGDFWKLHTLSQNILLCNAFQGAPTPWLEHTQVQAPTSSAPSSTASRALLPPTLSSLGLSTQNWCAKCNLAFRLTADLVFHMRSHHKREHVGPDPHSKKRREEVLTCPVCHEYFRERHHLSRHMASHS