wanglab/gogpt-training-data huggingface dataset:
Protein: Meteorin-like protein (Subfatin) (Q641Q3)
Organism: Homo sapiens (Human)
Function: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MRGAARAAWGRAGQPWPRPPAPGPPPPPLPLLLLLLAGLLGGAGAQYSSDRCSWKGSGLTHEAHRKEVEQVYLRCAAGAVEWMYPTGALIVNLRPNTFSPARHLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGRVQCFGLEQGGLFVEATPQQDIGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGSIQQVTHEPERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMHFGEARLGCAPRFKDFQRMYRDAQERGLNPCEVGTD
Protein: 2,4-dinitroanisole O-demethylase subunit alpha (DNAN hydrolase subunit alpha) (DNHA) (EC 3.3.2.14) (A0A096ZEC9)
Organism: Nocardioides sp. (strain JS1661)
Function: Involved in the degradation of 2,4-dinitroanisole (DNAN), an insensitive munition ingredient used in explosive formulations as a replacement for 2,4,6-trinitrotoluene (TNT). Catalyzes the removal of the methyl group from 2,4-dinitroanisole (DNAN) to yield 2,4-dinitrophenol (2,4-DNP) and methanol.
Interaction partners:
Sequence:
MSVTSQTSSSGSAAVSDCHRGIIDISGPVPGYEWEPSMTTEPVRGRVWTITDGVFRTLAIEGDTGVIAVDTFWSPGSARQYRRALQSHFPRKPVHTIIYTHDHLDHTGFGADFAPDADQILAHELTAEVIARRSSDGQLPATRTWSGERLEVSIDGAEFELIYPGPTHGTGNTALYFPNERFLYMADTVFTGPTYNIVPDFLWTSWIPNTRRLLGLDWDLYVPGHFWRLSRREFEADFELWDATAACALDALRAGVDIDNFADVKKFTYERMDEPFGSRTFRFDEFAAINVLTHMVHYQTGGWGLRDYEPYSNEPFKTTLPQRLGSPL
Protein: DEAD-box ATP-dependent RNA helicase 7 (EC 3.6.4.13) (Q39189)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ribosome production factor 2 homolog
- Ribosome biogenesis regulatory protein homolog
- Pumilio homolog 24
- Large ribosomal subunit protein uL3m
- Pescadillo homolog
- Expressed protein
- Cold shock domain-containing protein 3
- Eukaryotic translation initiation factor 5B
- Eukaryotic translation initiation factor 5B
- Eukaryotic translation initiation factor 5B
Sequence:
MPSLMLSDKKEEKKMKKKMALDTPELDSKKGKKEQKLKLSDSDEEESEKKKSKKKDKKRKASEEEDEVKSDSSSEKKKSSKKVKLGVEDVEVDNPNAVSKFRISAPLREKLKANGIEALFPIQASTFDMVLDGADLVGRARTGQGKTLAFVLPILESLVNGPAKSKRKMGYGRSPSVLVLLPTRELAKQVAADFDAYGGSLGLSSCCLYGGDSYPVQEGKLKRGVDIVVGTPGRIKDHIERQNLDFSYLQFRVLDEADEMLRMGFVEDVELILGKVEDSTKVQTLLFSATLPSWVKNISNRFLKRDQKTIDLVGNDKMKASNSVRHIAIPCNKAAMARLIPDIISCYSSGGQTIIFAETKVQVSELSGLLDGSRALHGEIPQSQREVTLAGFRNGKFATLVATNVAARGLDINDVQLIIQCEPPREVEAYIHRSGRTGRAGNTGVAVTLYDSRKSSVSRIEKEAGIKFEHLAAPQPDEIARSGGMEAAEKVKQVCDSVVPAFLEAAKELLETSGLSAEVLLAKALAKTAGFTEIKKRSLLTSMENYVTLHLEAGKPIYSPSFVYGLLRRVLPDDKVEMIEGLSLTADKTGAVFDVKQSDLDLFIAGAQKSAGSMSLEVVKVMPKLQEREPLPQKRFGGGGRGNRFGGGGGNRFGGGGGRGRGGSGGRGQRY
Protein: Collagen alpha-1(XIII) chain (COLXIIIA1) (Q5TAT6)
Organism: Homo sapiens (Human)
Function: Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11013208}; Single-pass type II membrane protein {ECO:0000269|PubMed:11013208}. Postsynaptic cell membrane {ECO:0000269|PubMed:26626625}.
Interaction partners:
- Prolyl 4-hydroxylase subunit alpha-1
- Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
- Procollagen galactosyltransferase 2
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-3
Sequence:
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLLAHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCPPGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLDGKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGSPGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGEKGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK
Protein: Heterokaryon incompatibility protein s (Small s protein) (Vegetative incompatibility protein s) (Q03689)
Organism: Podospora anserina (Pleurage anserina)
Function: Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MSEPFGIVAGALNVAGLFNNCVDCFEYVQLGRPFGRDYERCQLRLDIAKARLSRWGEAVKINDDPRFHSDAPTDKSVQLAKSIVEEILLLFESAQKTSKRYELVADQQDLVVFEDKDMKPIGRALHRRLNDLVSRRQKQTSLAKKTAWALYDGKSLEKIVDQVARFVDELEKAFPIEAVCHKLAEIEIEEVEDEASLTILKDAAGGIDAAMSDAAAQKIDAIVGRNSAKDIRTEERARVQLGNVVTAAALHGGIRISDQTTNSVETVVGKGESRVLIGNEYGGKGFWDN
Protein: 1-deoxyxylulose-5-phosphate synthase YajO (EC 1.1.-.-) (P77735)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the conversion of ribulose 5-phosphate (Ru5P) to 1-deoxy-D-xylulose 5-phosphate (DXP), providing a direct route from pentoses to terpenes. May play a role in biosynthesis of DXP under conditions of thiamine starvation.
Interaction partners:
- 1-deoxy-D-xylulose-5-phosphate synthase
- Methylglyoxal reductase DkgA
Sequence:
MQYNPLGKTDLRVSRLCLGCMTFGEPDRGNHAWTLPEESSRPIIKRALEGGINFFDTANSYSDGSSEEIVGRALRDFARREDVVVATKVFHRVGDLPEGLSRAQILRSIDDSLRRLGMDYVDILQIHRWDYNTPIEETLEALNDVVKAGKARYIGASSMHASQFAQALELQKQHGWAQFVSMQDHYNLIYREEEREMLPLCYQEGVAVIPWSPLARGRLTRPWGETTARLVSDEVGKNLYKESDENDAQIAERLTGVSEELGATRAQVALAWLLSKPGIAAPIIGTSREEQLDELLNAVDITLKPEQIAELETPYKPHPVVGFK
Protein: DM13 domain-containing protein (Q9XTR0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MRNSEFFLIFIISYSGVIRAIEYNGVSLGEFSESDVEGEVFLVNSTHLQIVNFRTTKTNLPPIPFAFISSNNQKSTPKIYRHFSSQNGEWLSKLVSLSHEQHQIDTRLIVKMTGSAAQWKQFAVVDSNGNTLASVNMNQKPSAPFCCFESEADMGLFGEYGIISDPIEVIDSRTLKIPKFSYKASQTPDGYFFAGAGSEIDQKSGKKAAILRSDQTLNYCPMLKDITDQDIIIRLDQSQTIYDIEWISVFCYKYSHDFGHLDMGLVENEEQVPPYIPDISISEPHVISQNC
Protein: Proteasome 26S non-ATPase subunit 9, putative (Q57X08)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proteasome regulatory ATPase subunit 5
- Protease regulatory ATPase subunit 4
- Proteasome regulatory ATPase subunit 6
- Proteasome regulatory ATPase subunit 3
- Katanin p60 ATPase-containing subunit A-like 2
- Proteasome regulatory non-ATP-ase subunit 2
- Proteasome regulatory ATPase subunit 1
- Proteasome regulatory non-ATP-ase subunit 5
- Probable 26S proteasome regulatory subunit rpn-6.2
- Nonspecific lipid-transfer protein, putative
Sequence:
MSGTLLKEELLQLDNKRRSIMRDIEEAMTFLNSTPVGLRGSLVDSEGFPRDDCDLYAVRRARHTVNCGHNDLKSIEATIHEKLSQLHEECRGEAEEQMQRDKMKKKSEDDQRRRDEQKQVMSSKEPFVRVVDVATGSPAEEGGLICGHLIVQYGDVDAEKVLEGGFGEMARVTSSYEGQMLRVWVRSPSDDDCGGARELFIVPQRWRGEGLLGCTFEPMKLN
Protein: Epoxide hydrolase (EC 3.3.2.9) (Q7K1W4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|PIRNR:PIRNR001112}. Microsome membrane {ECO:0000256|ARBA:ARBA00004111}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004111}.
Interaction partners:
- Carboxylic ester hydrolase
- Juvenile hormone acid O-methyltransferase
- Epoxide hydrolase
- Epoxide hydrolase
- Carboxylic ester hydrolase
- Lipid droplet-associated hydrolase
Sequence:
MKCLIVFGLIVALFGAFVGYGYVVFTELTKPLPKPEFKDDTYWGPGDAKDFVPDEKIYEFKLQVPQSEIDDLRKELNRTLRLTEPLDGIAFEYGFNTYALEQFVDYWRDNYLTKWDERQELFNSFKQYKTEIQGLNIHYIHEKVSEEAKEKKHVYPLLLLHGWPGSVREFFDFIPMLTKHSNITDYAFEVVAPSLVGYGWSDAATRPGFNAAEMATVMRNLMLRLGHKKFFIQGGDWGSIIGSNLATLYPENVIGYHSNMCVLHTPLAILKGIYGSFFPEKYLPSRFFVDHHFPVWEKWLELLEESGYFHIQATKPDTIGAALTSSPVGLASYILEKFQTCTNPGLKQDFGAIVTVFGLEAVLDNLMVYYLTNSATTAARFYLENVSKTYRDLQLDRVQSPVPMGCARFRFDLASVTDWQLRDKFPNLTHSMYFQQGSHFAALEMPAMLFNDFTAFVGKIGLHGEKRK
Protein: Spliceosome-associated protein CWC27 homolog (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (Q9XXI7)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Cell division cycle 5-like protein
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor CWC22 homolog
- Probable E3 ubiquitin-protein ligase rnf113
- BUD13 homolog
- RRM domain-containing protein
- Matrin-type domain-containing protein
- Tr-type G domain-containing protein
- Pre-mRNA-splicing factor 8 homolog
Sequence:
MSNQYINEPITTGKVTLETTAGDIEIELWTKEAPLACRNFIQLCMENYYKGTVFHRLVKNFILQGGDPTATGTGGESIYGKPFKDEIHQRLKFNRRGIVGMANAGRDDNGSQFFFTIGDRGAPELDKKHTIFGKVTGPTLFNMLKITEVETEGDRPVTFYKITGARIDNNPFDDLKPREKRKKEKSERRKEPKVVETKKTNLLSFGDEVEEDEQELAVFNKKTANKPKSAHDAHDNDTVGLSKQAAVTRDEMSNYCPEDDDTVKDESSISSIREKLMKKSQKRKLEEKAGGEDEDYEKMIEDERNAKERETIDKMNSELKDMQKEYMKALRPVKEKKKAVKDETLSEAMQSYHDLKMRFKSKTKDVVKQKDAQREGQTMNMLERFKNRLGASNQKAILFDKKIEIKEPILRNEGEEGEEKKFGTMDLDAEDIQGTSWMSHRFKAEDVVLSSKAKDANMREESEDWYHITDPRNKMAKRRRGEE
Protein: Aquaporin-6 (AQP-6) (Aquaporin-2-like) (Kidney-specific aquaporin) (hKID) (Q13520)
Organism: Homo sapiens (Human)
Function: Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9WTY0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Aquaporin-10
- Aquaporin-11
- Putative aquaporin-12A
Sequence:
MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV
Protein: Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Q9V9W3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein P1
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS12
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein eL22
- Large ribosomal subunit protein uL16
- Ribosomal protein S30, isoform A
Sequence:
MAPIEKAKKVAKSAKKGKKHPVNSYLKGGILRYSKAQMYKRRALYRLKDKKSPVVEKAKVPIKKVKKIGGPKNGGERTVFLKKSKASYPTKTFVKKRPSKANFSEHKRNTRRNLTPGTVLILLAGRHQGKRVVLLKVLASGLLLVTGPFALNSCPLRRVSQRYVIGTSSKVDLGAFKVPEHLNDAYFRRLKAKKDKKTGEADIFAAKKERFVPNEQRKKDQKEVDAALLKVIKAHPEGKFFAKYLQNMFALHSSQYPHRMRF
Protein: Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) (Q9H8M2)
Organism: Homo sapiens (Human)
Function: Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR).
Subcellular location: Nucleus {ECO:0000269|PubMed:25593309}.
Interaction partners:
- BRD4-interacting chromatin-remodeling complex-associated protein-like
- BRD4-interacting chromatin-remodeling complex-associated protein
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- SWI/SNF complex subunit SMARCC1
- Actin-like protein 6A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
- AT-rich interactive domain-containing protein 1A
- SWI/SNF complex subunit SMARCC2
- B-cell CLL/lymphoma 7 protein family member A
Sequence:
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLGKVKKELDPDDSHLNLDETTKLLQDLHEAQAERGGSRPSSNLSSLSNASERDQHHLGSPSRLSVGEQPDVTHDPYEFLQSPEPAASAKT
Protein: Outer envelope pore protein 21B, chloroplastic (Chloroplastic outer envelope pore protein of 21 kDa B) (Q9FPG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Voltage-dependent rectifying anion channel that facilitates the translocation between chloroplast and cytoplasm of phosphorylated carbohydrates such as triosephosphate, 3-phosphoglycerate and inorganic phosphate (Pi) depending of ATP to triosephosphate ratio in the plastidial intermembrane space; in high triosephosphate/ATP conditions (e.g. photosynthesis), export of triosphosphate from chloroplast (outward rectifying channels), but in high ATP/triosephosphate conditions (e.g. dark phase), import of phosphosolutes (inward rectifying channels) (By similarity).
Subcellular location: Plastid, etioplast membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Plastid, chloroplast outer membrane; Multi-pass membrane protein. Note=Present in non-green root plastids. {ECO:0000250}.
Interaction partners:
- Rhodanese-like domain-containing protein 11, chloroplastic
- Zinc finger/BTB domain protein
- YlmG homolog protein 2, chloroplastic
- 6,7-dimethyl-8-ribityllumazine synthase
- Myb/SANT-like DNA-binding domain protein
- Mitochondrial import receptor subunit TOM40-1
- Outer envelope pore protein 24A, chloroplastic
Sequence:
METSMRYTSNSKSMKIHAKEKVPVNSKTHLQLHGELDTGTGAPSYFCAMIRHFFPEASTGLGVGLHYDKRQKLRCLVRGKKEFPVRADKRVTFNIKGRCDIDQDLNQKNPKGAAEFAWNIMDFKEDQDVRIKVGYEMFDKVPYMQIRENNWTLNANMKGKWNLRYDL
Protein: Probable metabolite transport protein YBR241C (P38142)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- GTP cyclohydrolase-2
- Vacuolar protein sorting-associated protein 73
- Uncharacterized membrane protein YCR061W
Sequence:
MAETERLMPNGGSRETKPLITGHLILGTIVACLGSIQYGYHIAELNAPQEFLSCSRFEAPDENISYDDTWVGQHGLKQCIALTDSQYGAITSIFSIGGLFGSYYAGNWANRYGRKYVSMGASAMCMVSSLLLFFSNSYLQLLFGRFLVGMSCGTAIVITPLFINEIAPVEWRGAMGSMNQVSINLGILLTQTLALKYADSYNWRWLLFSGSVIAVANILAWLKVDESPRWLVSHGFVSEAETALFKLRPGTYQQAKQEIQDWQRSHGHNRDPESSEETHSGPTLWQYVTDPSYKKPRTVILAILSCQQFCGINSIIFYGVKVIGKILPDYSIQVNFAISILNVVVTLAASAIIDHVGRRPLLLASTTVMTAMSLLISVGLTLSVSFLLVTATFVYIAAFAIGLGPIPFLIIGELSYPQDAATAQSFGTVCNWLATFIVGYLFPIGHGLMGGYVFAIFAAIAAMFATYVYKRVPETKGKTTYSEVWAGY
Protein: Superoxide-generating NADPH oxidase heavy chain subunit A (EC 1.-.-.-) (NADPH oxidase A) (Superoxide-generating NADPH oxidase flavocytochrome A) (Q9XYS3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Critical component of the membrane-bound oxidase that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Peroxinectin A
- Culmination specific protein 37D
- Superoxide-generating NADPH oxidase light chain subunit
- Putative D-lactate dehydrogenase
- Eukaryotic translation initiation factor 2A
Sequence:
MRLPTKEEIQRYWVNEGNKLILVILYTLGNIAAFVYTFVHYYNSPAFEVVGYGVCFARGCAQLLKLNCALILVPVLRNLLSFLRGTFLNNYVPFDKNIVFHKLIAWVICFATFGHVMAHFNNFRLYQDITPQEYKRILGIDYPNLTPIKYAFATLAGWTGHVVCIVMVLMYTSAVESIRRPMFEGFWYTHHLFVVFFGLLVVHGLHSILEPTSFWKWVIGPCALYIVERLIRLLRSKKTTMLIQARIHPSRVIEVRMKTERFKYKPGQYLFLNCPTIAQNEWHPFTITSAPEEDFVSCHINVVGNWTGKLSTLLNPDKKMGIVQENVLKSPDGKPILRIDGPFGAASEEVFKYKQVILVGAGIGVTPFASILKHIKYQMARTYNTTPLIDKVHFYWICRDRNSFEWFSGLIGELEMENHNNFLEIHPYLTGALSAQEIRDVMYGDEEKDLITGFTTPTQFGRPKWDEIFADHALRYAEKDVGVFFCGPKLLSKSLYKASTHYTKTTTCRFHYNKENF
Protein: Frizzled-6 (Fz-6) (Q8WMU5)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:Q61089}. Apical cell membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with FZD3 at the apical face of cells (By similarity). Localizes to the endoplasmic reticulum membrane in the presence of LMBR1L (By similarity). {ECO:0000250|UniProtKB:Q61089}.
Interaction partners:
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Low-density lipoprotein receptor-related protein
- Low-density lipoprotein receptor-related protein
- Protein Wnt
- Protein Wnt
- Receptor like tyrosine kinase.
- Ring finger protein 43.
- Protein Wnt
Sequence:
MEMFTFLLTCVFLPFVRGHSLFTCEPITVPRCMKMAYNMTFFPNLMRHYDQSTAAVKMEPFLPLANLECSPNIETFLCKAFVPACTDQINVVPPCRKFCEKVYSDCKKLIDTFGMRWPEELECDRLQYCDETVPVTFDPHTQFLGPQKNTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDRTACNKADEKLELGDTVVLGSQNKACTVLFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGIPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKTETRPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITNHDYLGQETLTEIQTSPETSVREVRADGASTPRSREQDCGEPASPAASSSRLCEEQADRKGRAGNGTDKISISESTRSEGRVTPKSDVTETGPMQSSSLQVPGSSEPGSLKGSTSLLVHSASGGRKEHGTGSHSDT
Protein: Calreticulin (Q43712)
Organism: Zea mays (Maize)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319, ECO:0000256|PIRNR:PIRNR002356}.
Interaction partners:
Sequence:
MAIRKGSSYAVAALLALASVAAVAGEVFFQEKFEDGWESRWVKSEWKKDENMAGEWNHTSGKWNGDAEDKGIQTSEDYRFYAISAEYPEFSNKDKTLVLQFSVKHEQKLDCGGGYVKLLGGDVDQKKFGGDTSYSIMFGPDICGYSTKKVHTILTKDGKNHLIKKDVPCETDQLTHVYTLIIRPDATYSILIDNEEKQTGSIYEHWDILPPKKIKDPEAKKPEDWDDKEYIPDPEDKKPEGYDDIPKEIPDPDAKKPEDWDDEEDGEWTAPTIPNPEYKGPWKQKKIKNPNYQGKWKAPMIDNPDFKDDPYIYAFDSLKYIGIELWQVKSGTLFDNIIITDDPALAKTFAEETWGKHKEAEKAAFDEAEKKKEEEDAAKGGDDEDDDLEDEEDDEKADEDKADSDAEDSKDSDDEKQHDEL
Protein: Tripartite motif-containing protein 75 (A6NK02)
Organism: Homo sapiens (Human)
Function: May play a role in female meiosis.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q3UWZ0}.
Interaction partners:
Sequence:
MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQCQEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSELSELELLSQIKIFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTPLLLEVKARAIGIFLDYEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYVGPDSQPLRICTGTVCE
Protein: Myelin and lymphocyte protein (T-lymphocyte maturation-associated protein) (P21145)
Organism: Homo sapiens (Human)
Function: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:35217805}. Note=Found in lipid rafts. {ECO:0000250|UniProtKB:O09198}.
Interaction partners:
- Inverted formin-2
- Occludin
Sequence:
MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFIFGGLVWILVASSLVPWPLVQGWVMFVSVFCFVATTTLIILYIIGAHGGETSWVTLDAAYHCTAALFYLSASVLEALATITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS
Protein: Zinc finger protein 343 (Q6P1L6)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MMLPYPSALGDQYWEEILLPKNGENVETMKKLTQNHKAKGLPSNDTDCPQKKEGKAQIVVPVTFRDVTVIFTEAEWKRLSPEQRNLYKEVMLENYRNLLSLAEPKPEIYTCSSCLLAFSCQQFLSQHVLQIFLGLCAENHFHPGNSSPGHWKQQGQQYSHVSCWFENAEGQERGGGSKPWSARTEERETSRAFPSPLQRQSASPRKGNMVVETEPSSAQRPNPVQLDKGLKELETLRFGAINCREYEPDHNLESNFITNPRTLLGKKPYICSDCGRSFKDRSTLIRHHRIHSMEKPYVCSECGRGFSQKSNLSRHQRTHSEEKPYLCRECGQSFRSKSILNRHQWTHSEEKPYVCSECGRGFSEKSSFIRHQRTHSGEKPYVCLECGRSFCDKSTLRKHQRIHSGEKPYVCRECGRGFSQNSDLIKHQRTHLDEKPYVCRECGRGFCDKSTLIIHERTHSGEKPYVCGECGRGFSRKSLLLVHQRTHSGEKHYVCRECRRGFSQKSNLIRHQRTHSNEKPYICRECGRGFCDKSTLIVHERTHSGEKPYVCSECGRGFSRKSLLLVHQRTHSGEKHYVCRECGRGFSHKSNLIRHQRTH
Protein: Melanocortin receptor 4 (MC4-R) (B0V1P1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Pro-opiomelanocortin protein
- Agouti-related neuropeptide.
- Proopiomelanocortin b.
- Melanocortin 2 receptor accessory protein.
- Melanocortin-2 receptor accessory protein 2B
- FTO alpha-ketoglutarate-dependent dioxygenase.
- Melanocortin-2 receptor accessory protein 2A
- Leptin receptor.
- Leptin
- Appetite-regulating hormone isoform X1
Sequence:
MNTSHHHGLHHSFRNHSQGALPVGKPSHGDRGSASGCYEQLLISTEIFLTLGLVSLLENILVIAAIVKNKNLHSPMYFFICSLAVADLLVSVSNASETVVMALITGGNLTNRESIIKNMDNVFDSMICSSLLASIWSLLAIAVDRYITIFYALRYHNIMTQRRAGTIITCIWTFCTVSGVLFIVYSESTTVLICLISMFFTMLALMASLYVHMFLLARLHMKRIAALPGNGPIWQAANMKGAITITILLGVFVVCWAPFFLHLILMISCPRNPYCVCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEICCCWYGLASLCV