wanglab/gogpt-training-data huggingface dataset:
Protein: Conserved hypothetical threonine and proline rich protein (O05857)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
- N-acetylmuramoyl-L-alanine amidase Rv3717
- Probable peptidoglycan glycosyltransferase FtsW
- 1,4-beta-xylanase
- Tyrosine recombinase XerC
- Possible oxidoreductase
- Conserved protein TB9.4
Sequence:
MALGAVATAVIINSGDSTSTKAIVGAPAPRTVISTSPRPTAPTSTSPHPSPSTLRPQLPPETVTTVAPPGTGPTTVPTRTPTAAPPQTAVPPPAPLNPRTVVYRVTGTKQLFDLVNVVYTDARGFPVTDFNVSLPWTKMVVLNPGVQTESVVATSLYSRLNCSIVNTGAQTVVASTNNAIIATCTR
Protein: Ammonia regulation of amino acid uptake protein (P32450)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in ammonia regulation of the GAP1 permease.
Interaction partners:
- WW domain-containing protein WWM1
- Antisense of depressing factor protein 1
- Vacuolar morphogenesis protein 10
- Putative uncharacterized protein HUR1
Sequence:
MDRSLQVYICMYPYLDGSKQYRFDELISFYRPCPKSLDNIKSHYRQIHHQIRRRTHQHHQIRRRTHQHHHRSNCSRQRQCLVRHSCGRQMRVLA
Protein: Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (CPEB-3) (Q28CH2)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). Does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). Inhibits differentiation of intermediate mesoderm from an early stage to inhibit pronephric differentiation but induce neural differentiation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q7TN99}. Nucleus {ECO:0000250|UniProtKB:Q7TN99}. Synapse {ECO:0000250|UniProtKB:Q7TN99}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TN99}. Postsynaptic density {ECO:0000250|UniProtKB:Q7TN99}. Note=Predominantly cytoplasmic in unstimulated neurons but translocates to the nucleus following neuronal stimulation. {ECO:0000250|UniProtKB:Q7TN99}.
Interaction partners:
- Serine/threonine-protein kinase PLK1
- non-specific serine/threonine protein kinase
- Cdc2-prov protein
- Uncharacterized protein
- Cyclin N-terminal domain-containing protein
- Lysyl oxidase homolog 2
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 1
- VPS8, CORVET complex subunit.
Sequence:
MQDDLLMDKSKAQQRQQPQQPPSSQTQQQQKEAASVAEPPSSRESSPPTHKDKMQMESPLLPGLSFQQEPPTTPSLSPSFGSTWSTGGSNSAVDDSFFPGITPVNGTMLFQNFPHHHHVNPVFGGTFSPQMGLAHQTQQQQRRSPASPNNHTAYTQRNAYSHQPILTNKPSSSPNSSSPSPSNWNNQQNAAWNTPSNPWGAMQPGRDPRRAVGVGVGVGVGVPSPLNPISPLKKTFSSNVIAPPKFSRASPLTPKSWVEDNAFRTDNGNTLLPLQDRNRPYDSFNLHTLENSLMDMIRTDHEPLKARMGLNFHHPGTDNIMALNTRSYGRRRGRSSLFPFEDGFLGDGHGDQSLSSGLSSPTHCQNGERIERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRHVPFHWS
Protein: Protein PsbN (P0C418)
Organism: Oryza sativa (Rice)
Function: May play a role in photosystem I and II biogenesis.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00293}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00293}.
Interaction partners:
Sequence:
METATLVAISISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
Protein: Sickle tail protein (Enhancer trap locus 4) (A2AQ25)
Organism: Mus musculus (Mouse)
Function: Required for normal development of intervertebral disks.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5T5P2}. Cytoplasm {ECO:0000269|PubMed:16204209}.
Interaction partners:
Sequence:
MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETRERMQAMEKQIASLTGLVQSALFKGPITSSSKEASSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKNLEFYHEDVRKSDVECENGPQVESQKVTAGALRPSGPPKWERVMVDSISDTSRTSECRADTFTEENATPNKSLFRDSRNYSQKNVPKVSFSSSGLNSLEGEINKGPNVSGLQCAIPDLENQKLNFGKTKEIGQQGQENADKSHIPLPTRSAEFSIHDVKTQDQDVPVTGYGQVVLRSKVGRHANMNMNEDGESTPSSPSEEHTATDNIAFMITKTAVQVLSSGEVHDIVSQKGQDVQTVNIDGRKETASQHEGTEGEEPVVCLDKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMLTEEKIEEEEEDENEDSGVRTSSQMSCEQVDSRSDRMGQKAETQSQPHVLSAELLTPGVQGVRKAEQRKLSSADSPDSGNKCGMVDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEEDGTLKQHKEAKRFEITRSQPEDALKTMARRQEQLSPEGTLPASRTDEIRKSTYRTLDSLEQTIKQLENTISEMSPRALVDTSCSSNRDCGASLPHMAQEVSPRSLLVLDEVPPAPEPPTSISPASRKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS
Protein: Uncharacterized MFS-type transporter C330.07c (Q12519)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Barrier septum. Cell tip. {ECO:0000255, ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MEPSQRSGSFSSISRRRSRVDSRPTYFKVTSKDLGFVDQVSEEYEFYTYPKKASEVESVTETFQSNRSSLVPTYPVDENANKLPPKVSIAFILINSLMSDMSLAVALPTSASYTQSLGGTNAFSGLVIGIPTLISLIFLYPMLCFANPKSANGYTLYFRPMVVSSFAHIFGHLLYCMAYRANWIYLILIGRMLNGIGFTTFLYHKKYTTDKLLVGQNRRTFLATMNILAQTLGFMAGPFLGGILAKATIHSKNAVWNQYTVASWVMLFMWFFYMLTIIFFFKEVTADKSEKVSQQKENDDEDRPKLSWKHKFLLFFLAEVAFIAYFTVNGYQASISIYTGKLYNYDAFQSGNFIALSALIVAPFILASSFLSRWLEDRHIMLGGLFLGILAVAIHLVLDAVHKLPMQVYFFLYSLMIYGYSIGSAPLISLSSKQLHPRHHNTASIVVQVGVSLSNTFGSICGGAIYNITTVGFISLCLGLAAVVYMQLIFMWGSLKCKTH
Protein: Vitellogenin 3, phosvitinless (F1QQQ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MWRLCLCLLVALAASEMANYEPFLNSKKTYEYKYEGLVQVGRELPHLVESALKLRCTFKIIGESPHTFVLQVSNVDFEDFNGIPGKSVFSPSKNITKHLSAEISQPIIFEYSKGQITDIRTAPGVSNTVVNIVRGILGFLQVTVKTTQSFYELIELGIHGLCQSSYTVDEDSNAKELIVTRIVDITNCQQPASLYRGMALAPEDKLSKQRGESVVSTVKHTYTVKSTADGGQITKAFAQERQYFSPFNVKGGNFRMLALRDIELLKVSDTTDKVVTGQVQSRGNLMYKTNKDLKPIPVVMLNLNDPVPKILDLIKRLAQANIYHVDSETSTEILDLIQLMRVTTLDNLEHLWKQVSGNDEHRRWFLDLVVEVTDERILKFLEARYKAGDITANEAGQALVVAFNHLSAEPVSVALAQEFLTIPFSKSHPLLWNTVVLAYGSLVHRYCVYTDPCPITVVQPLLNMAASSLSKNSEDEMVLALKSLGNAAHLSSFKTLLKFLPGYSNGAEKLSTRVQGAAVQAFRLLASRASHSVQDIVLNLFVQKHLPAEIRMLACIVLLETKPSTALISVVSEVLLEEADLQVASFSYSLLKGFAKSRTPDNQHLSIACNIAMKILTRKLGHLSYRYSKNLHFDWFHDDFLFGTSADVYMLQNESPIPTKLMLKGKFHFIGRILQFLEFGIRADGLKDLFAGKIPELTKDLGISDLASILKILSNWQSLPKDKPLLTAYARVFGQEAFLMDVSRDSVQSIIKSFSPSAGKESKVWERIQDVQKGTSWHWTKPHLVYEARFIQPTCLGLPVEISKYYSVVNAVTMKAKAEINPPPKEHLGELLSSDISMQTDGFIGVTKDHFLFHGINTDLFQCGTELKSKVSMGLPWAFDLKINPKEQTYEMNLTPSKSVTELFSVSSNVYAVLRNIEDPTSSKITPMMPETGESWQGVPLRMLPPLRDEQTKKSGMKFRQCAEAKIYGTALCIEAEAKRAHYLHEYPLYYLLGDTHFSYSLEPAKDAKPIEKIQIQVSASRQHPSVMSGMVNLNQRVFKETRDENTSCEERKTSSSLPVTQDLDVTPDPVVTVKALSLSPQAKPLGYEGVAFYLPTAQKDDIEMIVSEVGEEANWKMCANAHFDKTHTSAKAHLRWGAECQTYDVSMRVSAACQPESKPSISTKINWGTLPSVFTTVGQIVQEYVPGVSYIMGFYQKKEENPERQASVIVVASSPETFDLKVKIPERTIYKKKIPSPIELLGIEAANLTMST
Protein: Peptidoglycan-recognition protein SC1b (EC 3.5.1.28) (C0HK99)
Organism: Drosophila melanogaster (Fruit fly)
Function: N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MVSKVALLLAVLVCSQYMAQGVYVVSKAEWGGRGAKWTVGLGNYLSYAIIHHTAGSYCETRAQCNAVLQSVQNYHMDSLGWPDIGYNFLIGGDGNVYEGRGWNNMGAHAAEWNPYSIGISFLGNYNWDTLEPNMISAAQQLLNDAVNRGQLSSGYILYGHRQVSATECPGTHIWNEIRGWSHWSG
Protein: Phosphoethanolamine transferase EptC (EC 2.7.-.-) (P0CB39)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}.
Interaction partners:
- Lipopolysaccharide export system protein LptA
- Lipopolysaccharide core heptose
- Phosphoenolpyruvate carboxylase
- Lipopolysaccharide glucosyltransferase WaaG
- Lipopolysaccharide glucosyltransferase WaaO
- Uncharacterized protein YjiK
Sequence:
MHSTEVQAKPLFSWKALGWALLYFWFFSTLLQAIIYISGYSGTNGIRDSLLFSSLWLIPVFLFPKRIKIIAAVIGVVLWAASLAALCYYVIYGQEFSQSVLFVMFETNTNEASEYLSQYFSLKIVLIALAYTAVAVLLWTRLRPVYIPKPWRYVVSFALLYGLILHPIAMNTFIKNKPFEKTLDNLASRMEPAAPWQFLTGYYQYRQQLNSLTKLLNENNALPPLANFKDESGNEPRTLVLVIGESTQRGRMSLYGYPRETTPELDALHKTDPNLTVFNNVVTSRPYTIEILQQALTFANEKNPDLYLTQPSLMNMMKQAGYKTFWITNQQTMTARNTMLTVFSRQTDKQYYMNQQRTQSAREYDTNVLKPFQEVLNDPAPKKLIIVHLLGTHIKYKYRYPENQGKFDGNTDHVPPGLNAEELESYNDYDNANLYNDHVVASLIKDFKAANPNGFLVYFSDHGEEVYDTPPHKTQGRNEDNPTRHMYTIPFLLWTSEKWQATHPRDFSQDVDRKYSLAELIHTWSDLAGLSYDGYDPTRSVVNPQFKETTRWIGNPYKKNALIDYDTLPYGDQVGNQ
Protein: Putative cargo-transport protein ypp1 (O94441)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in endocytosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Note=Found at the cell tip and the barrier septum.
Interaction partners:
- Phosphatidylinositol 4-kinase stt4
- Protein efr3
- Phosphatidylinositol 4-kinase pik1
- Pleckstrin homology domain protein opy1
- Protein sfk1
Sequence:
MFSAKAKTYELKLEQTRCNGDWQAIPEVARKLHKHNSSKSFVCELAKIEASLKSALTAELKNIANVLEPKLIDNQYSLIPALPSARTDPLLSQLNSLNIQNATEDEKLQETSIRLLLYIVQRKFPEAVDLDWSPQGIPWTETSTGICILQATVLSSLAQYAQANDEVAYQYVRSAIGLIQNANIGKKPLPELTRWCDLAYSLYAQMSVSACSSQLERANILTTCLSYFTEHKSVNLLYKLVTSRQAIKYLEHILRTNTNGSKIFTKSPVKNLYLNWPQLVLDYGSLLCNFTSFPKAGDQNMFAVEFIELATSIWINTEKSYDITVSLIRMLYQLTGKCFQAQQIFRSLVFFLRHIEEFEEASEAFEIYKFLCVKSHERLARKNSDVAGSFSDIKPVFVDEPKSIIEVCSVMMTVYAQYLRNLKKVSEILDYITKIASDYDLLKRDDIAPLIYHTEGVAYSFMYYQANNPSLRERYHQKSVQSYQKCLEKQPTNTNALFHLAMQYSERRAITDAMQIVRRLLEVNPKYSIVSWHLLVLCVSCSEQYAAGIKLIDSVFETWGINHVNEDGTIEISLTNLTFNDRCALVDLLITKLALFEAEKGVEATLDIQDEIFTLFASIFDLNEYRISKEGSSDELSTLLERSTIQSIKSSKKISKDVENEKGSILGFSRKSSLKRSTVLSKKSHSSYKENFQLRRGKTVSYLNQKLWLTAASLFLKSGNDDQARSALLEAKKIDHECAWVYYLNGLSLLQQGKEVEGYEQLDVAHYLDPEDPLISTALAKCLLQGGYGPMHSRRNRADAILSSCTLQYGWDLPEAWYYTAEIFRQLGDLKQAAFSYDYCIQLADTNPVRRWSNLQPRFMNV
Protein: Heterogeneous nuclear ribonucleoprotein A1 (F8VZ49)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRDSLLVAKFLGTQDLCLFLNLALSPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGG
Protein: Cyclin-J-like protein (Q8IV13)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMDEPWWEGRVASDVHCTLREKELKLPTFRAHSPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKQLYTVAVSCLLLANGVSLLSPRLKCSGMISAHCNLHLPGSSNSPASAPHPPPTPPQVAETTGKFEDREDHVPKLEQINSTRILSSQNFTLTKKELLSTELLLLEAFSWNLCLPTPAHFLDYYLLASVSQKDHHCHTWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISSYSLEHLSTCIEILLVVYDNVLKDAVAVKSQALAMVPGTPPTPTQVLFQPPAYPALGQPATTLAQFQTPVQDLCLAYRDSLQAHRSGSLLSGSTGSSLHTPYQPLQPLDMCPVPVPASLSMHMAIAAEPRHCLATTYGSSYFSGSHMFPTGCFDR
Protein: THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) (Q96J01)
Organism: Homo sapiens (Human)
Function: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Subcellular location: Nucleus {ECO:0000305}. Nucleus speckle {ECO:0000305}.
Interaction partners:
- THO complex subunit 2
- THO complex subunit 5
- THO complex subunit 4
- THO complex subunit 1
- THO complex subunit 7
- Spliceosome RNA helicase DDX39B
- THO complex subunit 6
- Ubiquitin carboxyl-terminal hydrolase CYLD
- Zinc finger protein GLI2
- SAP domain-containing ribonucleoprotein
Sequence:
MAVPAAAMGPSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDDKDGKYDSSREAGTVKLFGLPNDS
Protein: GD (Glycoprotein D) (US6) (G3G922)
Organism: Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MLLAALLAALVARTTLGADVDAVPAPTFPPPAYPYTESWQLTLTTVPSPFVGPADVYHTRPLEDPCGVVALISDPQVDRLLNEAVAHRRPTYRAHVAWYRIADGCAHLLYFIEYADCDPRQIFGRCRRRTTPMWWTPSADYMFPTEDELGLLMVAPGRFNEGQYRRLVSVDGVNILTDFMVALPEGQECPFARVDQHRTYKFGACWNDESFRRGVDVMRFLTPFYQQPPHREVVNYWYRKNGRTLPRAYAAATPYAIDPARPSAGSPRPRPRPRPRPKPEPAPVTPAPPGRLPEPATRDHAAGGHPTPRPPRPETPHRPFAPPAVVPSGWPQPAEPFQPRTPAAPGVSRHRSVIVGTGTAMGALLVGVCVYIFFRLRGAKGYRLLGGPADTDELKAQPGP
Protein: Bidirectional sugar transporter SWEET4 (AtSWEET4) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 4) (Q944M5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24027245}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- AT3g18370/MYF24_8
Sequence:
MVNATVARNIAGICGNVISLFLFLSPIPTFITIYKKKKVEEYKADPYLATVLNCALWVFYGLPMVQPDSLLVITINGTGLAIELVYLAIFFFFSPTSRKVKVGLWLIGEMVFVGIVATCTLLLFHTHNQRSSFVGIFCVIFVSLMYIAPLTIMSKVIKTKSVKYMPFSLSLANFLNGVVWVIYALIKFDLFILIGNGLGTVSGAVQLILYACYYKTTPKDDEDEEDEENLSKVNSQLQLSGNSGQAKRVSA
Protein: Plasma membrane ATPase (EC 7.1.2.1) (Q4WWZ4)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362083}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362083}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- inorganic diphosphatase
- Inorganic pyrophosphatase
- Plasma membrane ATPase
- Plasma membrane ATPase
Sequence:
MAERRISYAPDVENGDHSRHAENEGNLDEYTALNRYISTARDGRRGSTSSAGARSLQQKKKPWYAFWRKDAETGGAFVCPDEWLETDLRTGLASSQIETRRKKGGWNELTTEKTNFFVQFIGYFRGPILYVMELAVFLAAGLRDWIDLGVICGILLLNAVVGWYQEKQAADVVASLKGDIAMKAVVIRDGQEQEILARELVTGDIIVVEEGTVIPADIRLICDYDKPEMFETYKEYLATANDDTLKEKDDDDEDGGIEARVGVSLIAVDQSAITGESLAVDKYMADTCYYTTGCKRGKAYAIVTATAKQSFVGKTAALVQGAKDQGHFKAVMDNIGTTLLVLVMFWILAAWIGGFYRHLKIATPEHEDNNLLHYTLILLIIGVPVGLPVVTTTTLAVGAAYLAEQKAIVQKLTAIESLAGVDILCSDKTGTLTANQLSIREPYVNEGVDVNWMMAVAAIASNHNVKNLDPIDKVTILTLRRYPKAREILSRNWVTEKYTPFDPVSKRITTVCTCDGVRYVCAKGAPKAILNMSQCSEEEAAKFREKAAEFARRGFRSLGVAVQKEGEPWQLLGMYPMFDPPREDTAHTIAEAQHLGLSVKMLTGDALAIAKETCKMLALSTKVYDSERLIHGGLAGSAQHDLVEKADGFAEVFPEHKYQVVEMLQQRGHLTAMTGDGVNDAPSLKKADCGIAVEGSTEAAQAAADIVFLAPGLSTIVDAIKLARQIFQRMKAYIQYRIALCLHLEIYLVTSMIIIDETLRSDLVVFIALFADLATIAVAYDNAHYEMRPVEWQLPKIWVISIVLGVLLAGATWIMRASLFLNDGGLIQNFGSPQEMIFLEVALTENWLIFVTRGGKTWPSWQLVGAIFVVDVLATLFCVFGWLSGDYRQTSPPSHAEFSVNGDVDIVTVVVIWGYSIGVTIIIAVVYYILTIIPALDNLGRKTRSKADTKIENMIAHLSKLAIEHETDNNGKSYYTLGARAEVEEDDE
Protein: Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3) (Q8TAT5)
Organism: Homo sapiens (Human)
Function: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues.
Subcellular location: Nucleus {ECO:0000269|PubMed:12433996}. Chromosome {ECO:0000250|UniProtKB:A0A1L8HU22}. Note=Recruited to replication stress sites via interaction with ubiquitinated CMG helicase. {ECO:0000250|UniProtKB:A0A1L8HU22}.
Interaction partners:
- Endonuclease 8-like 1 lyase Neil1)
- Endonuclease III-like protein 1
- N-glycosylase/DNA lyase
- DNA topoisomerase 2-alpha
- Exonuclease 1
- Flap endonuclease 1
- Adenine DNA glycosylase
- DNA repair nuclease/redox regulator APEX1
- DNA polymerase theta
- Chromosome-associated kinesin KIF4A
Sequence:
MVEGPGCTLNGEKIRARVLPGQAVTGVRGSALRSLQGRALRLAASTVVVSPQAAALNNDSSQNVLSLFNGYVYSGVETLGKELFMYFGPKALRIHFGMKGFIMINPLEYKYKNGASPVLEVQLTKDLICFFDSSVELRNSMESQQRIRMMKELDVCSPEFSFLRAESEVKKQKGRMLGDVLMDQNVLPGVGNIIKNEALFDSGLHPAVKVCQLTDEQIHHLMKMIRDFSILFYRCRKAGLALSKHYKVYKRPNCGQCHCRITVCRFGDNNRMTYFCPHCQKENPQHVDICKLPTRNTIISWTSSRVDHVMDSVARKSEEHWTCVVCTLINKPSSKACDACLTSRPIDSVLKSEENSTVFSHLMKYPCNTFGKPHTEVKINRKTAFGTTTLVLTDFSNKSSTLERKTKQNQILDEEFQNSPPASVCLNDIQHPSKKTTNDITQPSSKVNISPTISSESKLFSPAHKKPKTAQYSSPELKSCNPGYSNSELQINMTDGPRTLNPDSPRCSKHNRLCILRVVGKDGENKGRQFYACPLPREAQCGFFEWADLSFPFCNHGKRSTMKTVLKIGPNNGKNFFVCPLGKEKQCNFFQWAENGPGIKIIPGC
Protein: Sol1, isoform C (A8JQY3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein amnionless
- GH12419p1
Sequence:
MESSFTVSHWPLTMPAASLALGLTVVLLATGNGQSQQAVTNSKQSHFWLDCSCLHLSERNATQWGRLAINASHSLGAKNNCLMIFIAGMDDELVAFQLEQLQLRAGCLDSVDIFPYLREPVIENATLAADTFCQHSRERSATPIYSAGRLLGLRLRFQQPPTDLASWNLTLNASYRFLKRENFRTDGRLVPHSFCDFYFFASLSGEEANMGQGYFHSPQFPAHYPAHIKCAYKFIGRPDTHVEILFEELQLPPVVSGGCQLDALTLFDAESAHMNSVIDVICSSRPTRRLVSTGPDLLLEFNASSNRTAKGFRGKYKFVSNDLGVPNASVPPPAVLEAASVVVKQEKLQQEQASAAKENSLMSDVELSKPGRSFEQCKQTFDSRVNKSGIFDSNQLLLAKHALGGVVIGGSRVLQCRYEFEAQAPERVQIRFHDFNVPTEHENSTGCQPGDALHVVTELRGRYETQELLCGAFLPKPLMSSGQQLHLQFVGKYPPTMTNKVQYYGFRAEYRFLTNFGIMSGIQKEGCSFVYNSSERISGLFHSPNFPGYYLENVVCNYYFYGASDERVVLHFTYFDIEGIGSCDHQTASDYIEFSNFMSTDRKFSRYCGKLPDFEMRSDGRFFRVTLHSNDRFVAIGFRALYTFETVSVNNSITDLRDNASMQSFVSTASTQPVANVNKLIACILCTYKAYQSYV
Protein: BTB/POZ domain-containing protein 9 (Q96Q07)
Organism: Homo sapiens (Human)
Interaction partners:
- UBX domain-containing protein 7
- UBX domain-containing protein 1
- FAS-associated factor 1
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL23m
- Dual specificity mitogen-activated protein kinase kinase 5
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL4m
Sequence:
MSNSHPLRPFTAVGEIDHVHILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKHNSKENHAEIMQAVRLPLMSLTELLNVVRPSGLLSPDAILDAIKVRSESRDMDLNYRGMLIPEENIATMKYGAQVVKGELKSALLDGDTQNYDLDHGFSRHPIDDDCRSGIEIKLGQPSIINHIRILLWDRDSRSYSYFIEVSMDELDWVRVIDHSQYLCRSWQKLYFPARVCRYIRIVGTHNTVNKIFHIVAFECMFTNKTFTLEKGLIVPMENVATIADCASVIEGVSRSRNALLNGDTKNYDWDSGYTCHQLGSGAIVVQLAQPYMIGSIRLLLWDCDDRSYSYYVEVSTNQQQWTMVADRTKVSCKSWQSVTFERQPASFIRIVGTHNTANEVFHCVHFECPEQQSSQKEENSEESGTGDTSLAGQQLDSHALRAPSGSSLPSSPGSNSRSPNRQHQ
Protein: Nucleoid-associated protein Lsr2 (P9WIP7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Binds in the minor groove of AT-rich DNA. Represses expression of multiple genes involved in a broad range of cellular processes, including major virulence factors or antibiotic-induced genes, such as iniBAC or efpA, and genes important for adaptation of changing O(2) levels. May also activate expression of some gene. May coordinate global gene regulation and virulence. Also protects mycobacteria against reactive oxygen intermediates during macrophage infection by acting as a physical barrier to DNA degradation; the physical protection has been questioned. A strain overexpressing this protein consumes O(2) more slowly than wild-type.
Subcellular location: Cytoplasm, nucleoid {ECO:0000269|PubMed:18187505, ECO:0000269|PubMed:20133735}.
Interaction partners:
- DNA-binding protein HupB
- Integration host factor
- DNA-directed RNA polymerase subunit omega
- L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
- Phosphoglucosamine mutase
- ATP-dependent Clp protease ATP-binding subunit ClpC1
- Aspartate 1-decarboxylase
- Pantothenate synthetase
- Type III pantothenate kinase
- Conserved hypothetical alanine and leucine rich protein
Sequence:
MAKKVTVTLVDDFDGSGAADETVEFGLDGVTYEIDLSTKNATKLRGDLKQWVAAGRRVGGRRRGRSGSGRGRGAIDREQSAAIREWARRNGHNVSTRGRIPADVIDAYHAAT
Protein: Meiotic recombination protein SPO11-1 (AtSPO11-1) (EC 5.6.2.2) (Q9M4A2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
Subcellular location: Nucleus {ECO:0000269|PubMed:17785529}.
Interaction partners:
- Type 2 DNA topoisomerase 6 subunit B-like
- DNA topoisomerase 6 subunit B
- Protein PUTATIVE RECOMBINATION INITIATION DEFECT 1
- Meiotic recombination protein DMC1 homolog
- DNA mismatch repair protein MSH4
- DNA repair protein RAD51 homolog 1
- Crossover junction endonuclease MUS81
- DNA repair protein RAD51 homolog 3
- Meiosis-specific protein ASY1
- Protein MULTIPOLAR SPINDLE 1
Sequence:
MEGKFAISESTNLLQRIKDFTQSVVVDLAEGRSPKISINQFRNYCMNPEADCLCSSDKPKGQEIFTLKKEPQTYRIDMLLRVLLIVQQLLQENRHASKRDIYYMHPSAFKAQSIVDRAIGDICILFQCSRYNLNVVSVGNGLVMGWLKFREAGRKFDCLNSLNTAYPVPVLVEEVEDIVSLAEYILVVEKETVFQRLANDMFCKTNRCIVITGRGYPDVSTRRFLRLLMEKLHLPVHCLVDCDPYGFEILATYRFGSMQMAYDIESLRAPDMKWLGAFPSDSEVYSVPKQCLLPLTEEDKKRTEAMLLRCYLKREMPQWRLELETMLKRGVKFEIEALSVHSLSFLSEVYIPSKIRREVSSP