wanglab/gogpt-training-data huggingface dataset:
Protein: Arginase 1, mitochondrial (EC 3.5.3.1) (Arginine amidohydrolase 1) (B8AU84)
Organism: Oryza sativa subsp. indica (Rice)
Function: Catalyzes the hydrolysis of L-arginine to urea and L-ornithine. The latter can be utilized in the urea cycle or as a precursor for the synthesis of both polyamines and proline.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- ornithine carbamoyltransferase
- Acetylornithine deacetylase
- Arginine biosynthesis bifunctional protein ArgJ
- N-acyl-aliphatic-L-amino acid amidohydrolase
- N-acyl-aliphatic-L-amino acid amidohydrolase
- alanine--glyoxylate transaminase
- Ornithine aminotransferase
- Ornithine aminotransferase
- urease
- Delta-1-pyrroline-5-carboxylate synthase
Sequence:
MGGVAAGTRWIHHVRRLSAAKVSTDALERGQSRVIDASLTLIRERAKLKAELLRALGGVKASACLLGVPLGHNSSFLQGPAFAPPRIREAIWCGSTNSSTEEGKELNDPRVLTDVGDVPIQEIRDCGVEDDRLMNVVSESVKTVMEEDPLRPLVLGGDHSISYPVVRAVSEKLGGPVDILHLDAHPDIYDAFEGNIYSHASSFARIMEGGYARRLLQVGIRSITKEGREQGKRFGVEQYEMRTFSKDREKLESLKLGEGVKGVYISVDVDCLDPAFAPGVSHIEPGGLSFRDVLNILHNLQGDVVAGDVVEFNPQRDTVDGMTAMVAAKLVRELTAKISK
Protein: Single-minded homolog 2 (SIM transcription factor) (mSIM) (Q61079)
Organism: Mus musculus (Mouse)
Function: Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00632, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Aryl hydrocarbon receptor nuclear translocator 2
- Aryl hydrocarbon receptor nuclear translocator
Sequence:
MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVTTKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLDQVSTSKSQESWRTTLSTSQETRKSAKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECSQVGNWRTSPPTNAVAPPEQQLHSEASDLLYGPPYSLPFSYHYGHFPLDSHVFSSKKPGLPAKFGQPQGSPCEVARFFLSTLPASSECQWHCANSLVPSSSSPAKNLSEPSPVNAARHGLVPNYEAPSAAARRFCEDPAPPSFPSCGHYREEPALGPAKAPRQASRDAARLALARAPPECCAPPAPEPQAPAQLPFVLLNYHRVLARRGPLGSAAPGAPEAAGSLRPRHPGPVAASAPGAPRPHYLGASVIITNGR
Protein: Aspartyl aminopeptidase (EC 3.4.11.21) (E7EMB6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTRNSSTIIAFAVGGQYVPGNGFSLIGAHTDSPCLRVKRRSRRSQVGFQQVGVETYGGGIWSTWFDRDLTLAGRVIVKCPTSGRLEQQLVHVERPILRIPHLAIHLQRNINENFGPNTEMHLVPILATAIQEELEKGTPEPGPLNAVDERHHSVLMSLLCAHLGLSPKDIVEMELCLADTQPAVLGGAYDEFIFAPRLDNLHSCFCALQALIDSCAGPGSLATEPHVRMVTLYDNEEVGSESAQGAQSLLTELVLRRISASCQHPTAFEEAIPKSFMISADMAHAVHPNYLDKHEENHRPLFHKGPVIKVNSKQRYASNAVSEALIREVANKVKVPLQDLMVRNDTPCGTTIGPILASRLGLRVLDLGSPQLAMHSIREMACTTGVLQTLTLFKGFFELFPSLSHNLLVD
Protein: Cysteine-rich protein 3 (CRP-3) (Chromosome 6 LIM domain only protein) (h6LIMo) (Q6Q6R5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MSWTCPRCQQPVFFAEKVSSLGKNWHRFCLKCERCHSILSPGGHAEHNGRPYCHKPCYGALFGPRGVNIGGVGSYLYNPPTPSPGCTTPLSPSSFSPPRPRTGLPQGKKSPPHMKTFTGETSLCPGCGEPVYFAEKVMSLGRNWHRPCLRCQRCHKTLTAGSHAEHDGVPYCHVPCYGYLFGPKGGQPHPRHWDGMYMPEVWHVHGLWVCVDNFPCG
Protein: Endophilin-A3 (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) (SH3p13) (O35180)
Organism: Rattus norvegicus (Rat)
Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17088211, ECO:0000269|PubMed:9238017}. Early endosome membrane {ECO:0000269|PubMed:17088211}; Peripheral membrane protein {ECO:0000305|PubMed:17088211}. Note=Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons. {ECO:0000269|PubMed:17088211}.
Interaction partners:
- Activity-regulated cytoskeleton-associated protein
- Dynamin-2
- Synaptojanin-1
- E3 ubiquitin-protein ligase CBL
- Synaptojanin-2
- Huntingtin
- Endophilin-A2
- Endophilin-A1
- Dynamin-3
- E3 ubiquitin-protein ligase CBL-B
Sequence:
MSVAGLKKQFHKASQLFSEKISGAEGTKLDEEFLDMEKKIDITSKAVAEILSKATEYLQPNPAYRAKLGMLNTMSKLRGQVKATGYPQTEGLLGDCMLKYGRELGEDSAFGNSLVEVGEALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKKRVGKIPEEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQNKLELRIALASQVPRRDYMPKPVNTSSTNANGVEPSSSSKLTGTDIPSDQPCCRGLYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLRGESGFFPINYVEVIVPLPR
Protein: Girdin, isoform A (Q9VZT7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Intraflagellar transport protein 122 homolog
- G protein alpha i subunit subunit alpha 65A)
Sequence:
MAGTATATPMEIDEFVNSSIISWLESCLPRAELLAGYTSLLDGHIIHSVWLQIDPEPQNNPSELNDLNGKSLSIARAKNFECVVRNLKSFFEEELGQTILVLPDAFTLGHHPESKNGLEQMKTLLTLLLGAAVQCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLVLTEDSLERLTPQSMYTHILRLTKERDVMYLKWIDLACVETEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLAVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAISLESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVARNLNSTMDLDKSFSENEDDCNSGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESSFHESTSKMLELEKEKKKLSLKIEQMQENINRLTQQNVELEGVFKNALEENKKLQDAVDNRQKSYDRQSLEREADRQKLSDAEQHVETLNKEKQRIQTLNESIQRRADDLERLAESKTKELEQYLEKSRQYELTKQKLYEIEARVSTYERENASLLKEVSKLKEGSEQKSVQLDDSINRLDVQSKELQKLGKALEDSEQVHQKLVELEKQNQELASQRIIDQEMISTLRNDLVTGTLVTKKVRNNLEKLGLADEEPGELNVEHVVEKLVRNPETFKTVREIMLNVTREQLEEEEREGGVKSDMCVLCHRQEIFTVEKNIELAATPAPAPAQPSSQELRFEHKVRLSPARESAELTRIKDSNTQLQTENARLSVDVAALGSQITSLNTQHVALQLANSQLAAEKDSLLKEIDSLQQEHKHALQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELRDTREQQSALEQRIEELTIQNSNMKTCSEDLSILRTEHSKLTDDFRNLFATSDRFKNEYKNIQEQYKMVRMEHSSLKLQNTELSGELNAKSDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMDNVSQLLSQYQELLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKKPFASMLVRRVKKASSDLMNKVPSRNRRSWVDDARTNSQFVIGSESGGNESDNSNEEPLSIASDTHLLQRNVPLRQSLQRDLLDNSIQRGGAVRSSLQAQKRTDLNNSRRNSVHGSLEAPDVTGSSLTLGTAGSRRTVYLIDEHQKLPDGSTPGATQSQSVGGSGSVNAAPPTPAEPQTPQKSTENNAPVGPATFLMYNRINTTIGGASNSGDQSPLLQASGSVSGTTMQDDKSARKRTEDKSNSIWYEYGCV
Protein: Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) (Q9N0E7)
Organism: Bos taurus (Bovine)
Function: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
Interaction partners:
- Iron-sulfur cluster assembly enzyme ISCU
- Iron-sulfur cluster assembly enzyme ISCU
- Selenocysteine lyase
- Cysteine desulfurase
- Betaine--homocysteine S-methyltransferase 2
- Selenide, water dikinase 1
- NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
- Frataxin, mitochondrial
- Thiosulfate sulfurtransferase
- aldehyde oxidase
Sequence:
MAGGAAHPGAELLPFARFLDSSLQPLVYGYGRGTLHELRAREFGRLAGTVYLDHAGTTLFPQSQITSFMKDLMENVYGNPHSQNISSKLTHDTVEQVRFRILAHFHTSPEDYTVIFTSGSTAALKLVAEAFPWVSPGPEGSGSCFCYLTDSHTSVVGMRKITAAMNVSSIPVRPEDMWSAERQDAAAAGDPAGQPPHLFCYPAQSNFSGTRYPLSWIGEVKSGRRRPASRPGKWFVLLDAAAFVGTSPLDLSVHQADFVPISFYKIFGFPTGLGALLVNNRLAALLRKTYFGGGTAAAYLAGDDFYVPRESVAERFEDGTISFLDVIALKHGFDALERLTGGMESIRQHTFTLAQYTYTALSSLRYPNGAPVVQIYSDSDFSSPEVQGPVISFNVLDDHGNVVGYSQVDKMASLHNIHVRTGCFCNTGACQRHLGISDEMVKKHLQAGHVCGDDVDLIDGQPTGSVRISFGYMSTLEDAQAFLRFIIATRLHSSHGQPLPLATPGEAGAPPEDSEAQNAVPAARARGSSSPQEDTSPHSGVWNNSPTAVDAEGLCPPLLEATGTQQTTSEKAADVPDGDLRSHVITNLFLYPIKSCAAFEVIRWPLGSQGLLYDRSWMVVNHNGICLSQKQEPRLCLIQPFIDLQRRIMVIKAQGMEPIEVPLEENSEQVQICQSKVCADRVNTYDCGEKISNWLSKFFGRPYHLIKQSSDFQRNAKKKHGKDQSAHTTATLSLVNEAQYLLINRSSILELQQQLSTSCENGKEELFPMNNLISRFRANIITNGTRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQDVFQKLSERRERKVKFGVYLMHTSLDLSSPCYLSVGSQVLPLLKENMEHHDIPATE
Protein: Stress-activated protein kinase JNK (EC 2.7.11.24) (A3KBF5)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU368052}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMILISGIKLLNSSEHLVLNS
Protein: Calcipressin-1 (Down syndrome critical region protein 1 homolog) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1) (Q9JHG6)
Organism: Mus musculus (Mouse)
Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Interaction partners:
- Protein phosphatase 3 catalytic subunit alpha
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
- Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
- Calcineurin subunit B type 1
Sequence:
MEDGVAGPRLGEVAEAVEARAPRRVTLRPFAPFSAAAEGDGGGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDTTFQYFKSFKRVRINFSNPLSAADARLRLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQENEEEEEEMERMKRPKPKIIQTRRPEYTPIHLS
Protein: 3-ketosteroid-9-alpha-monooxygenase, oxygenase component (3-ketosteroid-9-alpha-hydroxylase, oxygenase component) (KSH) (Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase) (EC 1.14.15.30) (Rieske-type oxygenase) (RO) (P71875)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. KSH is also able to use 4-androstene-3,17-dione (AD), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4-BNC), 3-oxo-23,24-bisnorcholesta-4-en-22-oyl-coenzyme A thioester (4-BNC-CoA) and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA) as substrates.
Interaction partners:
- 3-oxosteroid 1-dehydrogenase
- 3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component
- Uncharacterized protein
- Iron-dependent extradiol dioxygenase
- Flavin-dependent monooxygenase, oxygenase subunit HsaA-triene-9,17-dione 4-hydroxylase, oxygenase subunit)-triene-9,17-dione monooxygenase)
- 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1
- HTH-type transcriptional repressor KstR
- (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA hydrolase (HIEC-CoA hydrolase)
- Acyl-CoA dehydrogenase IpdE1
- HTH-type transcriptional repressor KstR2
Sequence:
MSTDTSGVGVREIDAGALPTRYARGWHCLGVAKDYLEGKPHGVEAFGTKLVVFADSHGDLKVLDGYCRHMGGDLSEGTVKGDEVACPFHDWRWGGDGRCKLVPYARRTPRMARTRSWTTDVRSGLLFVWHDHEGNPPDPAVRIPEIPEAASDEWTDWRWNRILIEGSNCRDIIDNVTDMAHFFYIHFGLPTYFKNVFEGHIASQYLHNVGRPDVDDLGTSYGEAHLDSEASYFGPSFMINWLHNRYGNYKSESILINCHYPVTQNSFVLQWGVIVEKPKGMSEEMTDKLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQLRRWYEQFYVDVADIKPEMVERFEIEVDTKRANEFWNAEVEKNLKSREVSDDVPAEQH
Protein: Ankyrin repeat and BTB/POZ domain-containing protein 2 (Q7TQI7)
Organism: Mus musculus (Mouse)
Function: May be involved in the initiation of hepatocyte growth.
Interaction partners:
Sequence:
MAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYSGSMNSRHNSWDTVNTVLPEDPEVADLFSRCPRLPELEEFPWTEGDVARVLRKSVGGRRLPSFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVLASQSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGTSPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSPTVDSGDIRQAARLLLPGLDCEPRQLKPECCFSSFRRLDARAATERFNQDLGFRMLNCGRTDLISQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSHSPRHPSVHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNSGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEANGMASSLHEEMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDTSSQGSSEGPVRLSRTRTKALQEAMYYSAEHGYLDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLKDFSSIKEEEYNEELVTEGLQLMFDILKTSKNDSVLQQLATIFTHCYGTSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDIKYHIFQMLMQYLYYGGTESMEIPTADILQLLSAANLFQLDALQRHCEILCSQTLSVESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDLQSTLAERVHSVYVTSRV
Protein: NAD(P)H-quinone oxidoreductase subunit S, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit S) (NDH subunit S) (NADH-plastoquinone oxidoreductase subunit S) (Protein CHLORORESPIRATORY REDUCTION 31) (Q9T0A4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable). Required for the efficient operation of ferredoxin-dependent plastoquinone reduction. Forms the electron donor-binding subcomplex in association with the NDHT and NDHU subunits.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:21505067}; Peripheral membrane protein {ECO:0000269|PubMed:21505067}; Stromal side {ECO:0000269|PubMed:21505067}.
Interaction partners:
- NAD
- Photosynthetic NDH subunit of subcomplex B 2, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 1, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 3, chloroplastic
- NAD
- NAD
- NAD
- Photosynthetic NDH subunit of subcomplex B 4, chloroplastic
- NAD
- NAD
Sequence:
MATSSITIPTIRTPIHRSKFLGQTHQFSTVNRSVFPPPKQQSKLYQVKAMGKFNLWEVMGGRGLCNGEKGIEKELQRNIEDEQETSKAENNETERESDDSNLSFKVPEDGFEKEMMGLTGGFPGGEKGLKTFIEKNPPPPPPPPPAKQGSDASAVATDKKPKAPKLPLLMPGMIAIVKNQNSPYHMYCGIVQRITDGKAGVLFEGGNWDRLITFRLEELERREKGPPGKNPKSCILEPLIEQMQKEEAAP
Protein: Uncharacterized transcriptional regulatory protein C1773.12 (O94569)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus membrane {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized transcriptional regulatory protein C965.10
Sequence:
MVPIKKISTACDLCRQRKLRCNGELPKCQNCVVYSETCKYNKRKRVKKPNVDKDDPHIVVGQPPVKKSTAGITREYTEMIELRNHIITLSKRSVNMESRIDDMLNLLNYDLSEKRETSNEIPSLVQQIQNCGFLIDEKMRRYPGIFQIHPKDYTMNDLFPQSFPTWISVYRNVPEKAWANRCVEWYFRYINSCWPLFDLENFMDLFDNFYSDKEKTKGAWVVSFYAIMALAVSRSKRKDKEKISKSLFSTSWFLVQKPGFFLTARLDKIQALTIMIQFCAHLSLYNLCKVLCGQMCLMVKDLDLHKEATNPNVDIEVDELNRRVFWTCYIFETTTSLIFGTPPELGDLEIDCQLPSMDVLPRFTESSQGGIVFCSEIQLTIIKNEIRKKIYKCLASASEEVYKEAVLSIRGKLIVWERNLPDELKQYYDVIKLNGTIPKNVDFENQHIFTACVEIYLSYCITQLYFYDPLTNYETCLEIARKAADAIRSYFMVIEPIFKKICYLWLFLYCPFTPFQILFSNILKMEKGTSDEKIEDLDRMYSLYRFFVEMKEINGEFADKLSRVALDCIDAAEHYLELKSSVGSNIFELESLLV
Protein: Growth factor-independent 1B transcription repressor (Zinc finger protein Gfi-1b isoform X1) (E7FBX7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Rhombotin-2
- Endothelial transcription factor GATA-2a
- LIM domain-binding protein 1-A.
Sequence:
MPRSFLVKSKKSYNVHRPNDTEQAPQKLPEPEPKTIPALVPLEPKECKSPERPQVDPVTRPSHRDPYDFIKCEREPDCPIPSLPELPTATRRPFYISEPQLAEFPPYYKSSFGWDHGPASYQEFRHMGFSPSLLHHASSLYGAHLKQSAEPQPLDCSTHYSPSSNTYHCITCDKVFSTPHGLEVHVRRSHSGTRPFECSICRKSFGHAVSLEQHMNVHSQERSFECKMCGKTFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCEICSKGFQRKVDLRRHHESQHSLK
Protein: Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) (P09972)
Organism: Homo sapiens (Human)
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Fructose-bisphosphate aldolase A
- Triosephosphate isomerase
- ATP-dependent 6-phosphofructokinase, liver type
- ATP-dependent 6-phosphofructokinase, platelet type
- Glucose-6-phosphate isomerase
- ATP-dependent 6-phosphofructokinase, muscle type
- Fructose-1,6-bisphosphatase 1
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
- Fructose-1,6-bisphosphatase isozyme 2
Sequence:
MPHSYPALSAEQKKELSDIALRIVAPGKGILAADESVGSMAKRLSQIGVENTEENRRLYRQVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKGIVVGIKVDKGVVPLAGTDGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKISERTPSALAILENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACPIKYTPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASFNLNAINRCPLPRPWALTFSYGRALQASALNAWRGQRDNAGAATEEFIKRAEVNGLAAQGKYEGSGEDGGAAAQSLYIANHAY
Protein: Leucine-rich repeat-containing protein 39 (Myosin-interacting M-band-associated stress-responsive protein) (Myomasp) (Q96DD0)
Organism: Homo sapiens (Human)
Function: Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.
Subcellular location: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:D3ZXS4}.
Interaction partners:
- Myosin-7
Sequence:
MTENVVCTGAVNAVKEVWEKRIKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQESRRRADHQVNGSTTLPISINTDG
Protein: Arginine deiminase (ADI) (EC 3.5.3.6) (Arginine dihydrolase) (AD) (P13981)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Carbamate kinase
- Ornithine carbamoyltransferase, catabolic
- Arginine/ornithine antiporter
- Ornithine carbamoyltransferase, anabolic
- Argininosuccinate lyase
- N
- Argininosuccinate synthase
- Acetylornithine deacetylase
- Probable peptidic bond hydrolase
- Agmatine deiminase
Sequence:
MSTEKTKLGVHSEAGKLRKVMVCSPGLAHQRLTPSNCDELLFDDVIWVNQAKRDHFDFVTKMRERGIDVLEMHNLLTETIQNPEALKWILDRKITADSVGLGLTSELRSWLESLEPRKLAEYLIGGVAADDLPASEGANILKMYREYLGHSSFLLPPLPNTQFTRDTTCWIYGGVTLNPMYWPARRQETLLTTAIYKFHPEFANAEFEIWYGDPDKDHGSSTLEGGDVMPIGNGVVLIGMGERSSRQAIGQVAQSLFAKGAAERVIVAGLPKSRAAMHLDTVFSFCDRDLVTVFPEVVKEIVPFSLRPDPSSPYGMNIRREEKTFLEVVAESLGLKKLRVVETGGNSFAAEREQWDDGNNVVCLEPGVVVGYDRNTYTNTLLRKAGVEVITISASELGRGRGGGHCMTCPIVRDPIDY
Protein: Metabotropic GABA-B receptor subtype 2, isoform A (Q8IN24)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MFRPSWFPFASLLFLLLWSTACGRTAKRSDVYIAGFFPYGDGVENSYTGRGVMPSVKLALGHVNEHGKILANYRLHMWWNDTQCNAAVGVKSFFDMMHSGPNKVMLFGAACTHVTDPIAKASKHWHLTQLSYADTHPMFTKDAFPNFFRVVPSENAFNAPRLALLKEFNWTRVGTVYQNEPRYSLPHNHMVADLDAMEVEVVETQSFVNDVAESLKKLREKDVRIILGNFNEHFARKAFCEAYKLDMYGRAYQWLIMATYSTDWWNVTQDSECSVEEIATALEGAILVDLLPLSTSGDITVAGITADEYLVEYDRLRGTEYSRFHGYTYDGIWAAALAIQYVAEKREDLLTHFDYRVKDWESVFLEALRNTSFEGVTGPVRFYNNERKANILINQFQLGQMEKIGEYHSQKSHLDLSLGKPVKWVGKTPPKDRTLIYIEHSQVNPTIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSPHLNNLIIVGCMMTYLSIIFLGLDTTLSSVAAFPYICTARAWILMAGFSLSFGAMFSKTWRVHSIFTDLKLNKKVIKDYQLFMVVGVLLAIDIAIITTWQIADPFYRETKQLEPLHHENIDDVLVIPENEYCQSEHMTIFVSIIYAYKGLLLVFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAAISLVLSDRKDLVFVLLSFFIIFCTTATLCLVFVPKLVELKRNPQGVVDKRVRATLRPMSKNGRRDSSVCELEQRLRDVKNTNCRFRKALMEKENELQALIRKLGPEARKWIDGVTCTGGSNVGSELEPILNDDIVRLSAPPVRREMPSTTVTEMTSVDSVTSTHVEMDNSFVSVQSTVMAPSLPPKKKKQSIVEHHSHAPAPTMMQPIQQQLQQHLQQHQQMQQQHLQQQQHQQMQQQQQQQQHHHRHLEKRNSVSAQTDDNIGSITSTAGKRSGGDCSSMRERRQSTASRHYDSGSQTPTARPKYSSSHRNSSTNISTSQSELSNMCPHSKPSTPAVIKTPTASDHRRTSMGSALKSNFVVSQSDLWDTHTLSHAKQRQSPRNYASPQRCAEHHGGHGMTYDPNTTSPIQRSVSEKNRNKHRPKPQKGTVCQSETDSERERDPPPNSQPCVQPRKVSRSSNIQHAAHHHSSPNVAPDKQRSRQRGKQDSSIYGASSETELLEGETAILPIFRKLLTEKSPNYRGRSAVGQSCPNISIKCDIVEYL
Protein: ECF sigma factor, VreI (Q9I5P9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- VreA
- Sigma factor regulator, VreR
- Porin
- Energy transducer TonB
- ECF sigma factor FoxI
- Anti-sigma factor FoxR
- FpvR
- DNA repair protein
- Transport protein ExbB2
- Probable transmembrane sensor
Sequence:
MSDSRQSAMVKLFLASYDDFKARLKRRLGSEDLACDVLHETYLRVDRLDDALEVKKPQAYLFRIALNIAADRREGDARLLTGEEVAELLQVADEGLDPERIVGGHAEIRRLLEALCELPARRRQILIASRLEETPHAEISRRFGISTRTVEKELKAALWFCAERLERKVIQRFGPGAGKPS
Protein: RE21922p (Sandman) (Q7JZM1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- FI03418p
Sequence:
MSSRRSSFRRREKPAFERFKDHCRHFTAFMFSNVGIILLVTFYIIGGAFIFQSIEIFEYERLKSEKPHRFIARNFSGECLSRIWELTAENISFFDHHAYRRRVNDVLLDYQRAIVKKQLKGPDVEQWSFSGAFLYSLTVITTIGYGNITPHSECGKLVTILYAIIGMPLFLLYLSNIGDVLAKSFKWIYSKVCLCRICPGVAKRRIIRERRKMRQLARALQMHDMENARGSSSYTSTSSTTSSNSSSSEYTRSSRQSSSLVDIQYTESDSDIEREIRGSTDEITVPVTVCVFVMVGYILWGALLFGRWEDWNYLDGSYFCLISLSSIGFGDLVPGDRVITADRDKVEVSFILCAIYLLLGMAVIAMCFNLMQEQVVHNIRAIKRGFKACFRCRTS
Protein: Mangetout, isoform F (A1Z7F5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MKTFCDESKWSVQICLLLLLVVLSTCHILQTESQVVGDIEQADDGVASSHRRSRSHSASHQAHVGNGNNPGCKHLHHRQHRGKSHARKHRQSHYEMLELEQRQQRMGKHWRQWMSHLQSPDYANDDPLPDGRRSSPANADLTYDHFELEDYQRYANIDLASPRSGRHRGRHLPLNNMNLMLPLSSADGSGKYLRSLPDSVSFQNDRLYATQPQRHWPVKREAIVEGDVILGGLMMVHSREDSITCGPIMPQGGIQALEAMLFTIDRINREQLLPNITLGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCEMATQTISSIITSLDINAYNQIPYADQYVPNNATTATTTPTDKGSGNGNSNSNSNTNGSSNSNSNSNGDGDVATEQVVANNNKINQRQHGQPAVAFAITSTNNHISGPAATITTTAATGETTTEALVATITTPLATVDGSETMSVAPNNGHGNNGSQRPPVLQTNL
Protein: Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (P62068)
Organism: Homo sapiens (Human)
Function: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:30466959}. Note=USP46/WDR48/WDR20 complex is predominantly cytoplasmic. {ECO:0000269|PubMed:30466959}.
Interaction partners:
- WD repeat-containing protein 48
- WD repeat-containing protein 20
- Polyubiquitin-B
- Ubiquitin-ribosomal protein eL40 fusion protein
- PH domain leucine-rich repeat-containing protein phosphatase 2
- Polyubiquitin-C
- PH domain leucine-rich repeat-containing protein phosphatase 1
- Dystrophia myotonica WD repeat-containing protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- RAD51-associated protein 1
Sequence:
MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE