wanglab/gogpt-training-data huggingface dataset:
Protein: Pentatricopeptide repeat-containing protein At3g04760, chloroplastic (Q9SR00)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- At3g22970
- Transmembrane protein
- Alpha-crystallin domain 32.1
- Probable transcription factor At4g00130
- AGAMOUS-like 57
- Probable protein phosphatase 2C 49
- Protein FAR1-RELATED SEQUENCE 6
- Elongation factor 1-beta 1
- Probable inactive histone-lysine N-methyltransferase SUVR2
- Heat stress transcription factor A-7b
Sequence:
MTPLSSELVGFTIPFYSKTQKPYSNSSHGLLLSHNRSSLLTFSNSNPNNDNGRSFSSSGARNLQTTTTTDATLPTERRQQHSQSLGFRDTQMLKIFHRSCRSGNYIESLHLLETMVRKGYNPDVILCTKLIKGFFTLRNIPKAVRVMEILEKFGQPDVFAYNALINGFCKMNRIDDATRVLDRMRSKDFSPDTVTYNIMIGSLCSRGKLDLALKVLNQLLSDNCQPTVITYTILIEATMLEGGVDEALKLMDEMLSRGLKPDMFTYNTIIRGMCKEGMVDRAFEMVRNLELKGCEPDVISYNILLRALLNQGKWEEGEKLMTKMFSEKCDPNVVTYSILITTLCRDGKIEEAMNLLKLMKEKGLTPDAYSYDPLIAAFCREGRLDVAIEFLETMISDGCLPDIVNYNTVLATLCKNGKADQALEIFGKLGEVGCSPNSSSYNTMFSALWSSGDKIRALHMILEMMSNGIDPDEITYNSMISCLCREGMVDEAFELLVDMRSCEFHPSVVTYNIVLLGFCKAHRIEDAINVLESMVGNGCRPNETTYTVLIEGIGFAGYRAEAMELANDLVRIDAISEYSFKRLHRTFPLLNVLQRSSQTFGY
Protein: At5g05510 (Mad3/BUB1 homology region 1) (Q9FFG4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mitotic spindle checkpoint protein MAD2
- Anaphase-promoting complex subunit 8
- Kinetochore protein NDC80 homolog
- Anaphase-promoting complex subunit 6
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 4
- Mitotic spindle checkpoint protein MAD1
- Anaphase-promoting complex subunit 2
Sequence:
MAKNENGYENLLASLIVDIKSYSGKDHLLPWIRGVKKMKESLPSQILNEKLPRFLQKCAESFESDKRYKNDSRYIRVWLQLMDFVDDPRALLRTMEAKSIGTKRSLFYQAYALHYEKMKRFEDAEKMYRLGVQNLAEPMDELQKSYLQFVTRMERHKKKKTQRQEQKLSGKHHKVDERQQHEPVLNFVDKAIVGKPEAENACHHGLVDPTINMKEAMNTINNMFKEPIETAPLQRRSRQRSQNKENQGCNNSFEVFLDENLECETGTSGKAKTSTTQCGSQPNQESFEIFIDDENTDETADENDEAGKAFVFLLPRDHSPESSEEADRNTPPRARFREDTVVRRFVGSTISDEPEAVENACHHGLVDPTVNLKEAMEDINNMFGEPINFVRPNRSKNKGKAVVETKPNPAAGFSILEDDDEEEAEQEHQGKSQPTQRLPSKSDERELFEPTVCTKVALDEINKLFAMPMDF
Protein: Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphatase, erythrocyte isozyme) (Acylphosphatase, organ-common type isozyme) (Acylphosphate phosphohydrolase 1) (P07311)
Organism: Homo sapiens (Human)
Interaction partners:
- Acetyl-coenzyme A thioesterase
- 4-trimethylaminobutyraldehyde dehydrogenase
- Acylphosphatase-2
- Aldehyde dehydrogenase X, mitochondrial
- Aldehyde dehydrogenase family 3 member A2
- Acetyl-coenzyme A synthetase, cytoplasmic
- Alpha-aminoadipic semialdehyde dehydrogenase
- Acetyl-coenzyme A synthetase 2-like, mitochondrial
- Aldehyde dehydrogenase, mitochondrial
Sequence:
MAEGNTLISVDYEIFGKVQGVFFRKHTQAEGKKLGLVGWVQNTDRGTVQGQLQGPISKVRHMQEWLETRGSPKSHIDKANFNNEKVILKLDYSDFQIVK
Protein: Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2) (Q6GN29)
Organism: Xenopus laevis (African clawed frog)
Function: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27619977}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NHH9}. Note=Localizes at endoplasmic reticulum (ER) three-way tubular junctions (PubMed:27619977). {ECO:0000269|PubMed:27619977}.
Interaction partners:
Sequence:
MAEGGSLRNRTRFGSRSNEAMNHVDYPDENFVEEIQLNSDTEVMEKPRPIQIVLAHEDDHNFELDETALESILMQDHIRDLNVVVLSVAGAFRKGKSFLLDFMLRFMYSQSSSWIGGNYEPLTGFTWRGGCERETTGIQIWSEVFVVEKPDGSKVAVILMDTQGAFDSQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAMEEIYKKPFQTLMFLIRDWSYPYEHSYGLEGGNKFLEKRLQVKQNQHEELQNVRKHIHSCFTNIGCFLLPHPGLKVATNPYFDGRLVEIDDEFKKELRELVPLLLAPENLVEKEISGSKVTCRDLLEYFKAYIKIYQGEELPHPKSMLQATAEANNMAAVAGAKDTYSRSMEQVCGGDKPYIAPSDLERKHLDLKETCIKQFRSVKKMGGEEFCRRYQEQLEAEIEETYANFLKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGMNSIATICNLIMGLTLLSFCTWAYVKYSGEFRELGTLIDQIAEIIWEQLLKPLSDNLMEDNIRQTVRNSIKAGLTDQVSGRLKTN
Protein: GTPase ArgK (EC 3.6.5.-) (G-protein chaperone) (P27254)
Organism: Escherichia coli (strain K12)
Function: Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis.
Interaction partners:
- Methylmalonyl-CoA mutase
- Methylmalonyl-CoA decarboxylase
- Propanoyl-CoA:succinate CoA transferase
- Zinc chaperone YjiA
- 3'
- Hydrogenase maturation factor HypB
- Zinc chaperone YeiR
Sequence:
MINEATLAESIRRLRQGERATLAQAMTLVESRHPRHQALSTQLLDAIMPYCGNTLRLGVTGTPGAGKSTFLEAFGMLLIREGLKVAVIAVDPSSPVTGGSILGDKTRMNDLARAEAAFIRPVPSSGHLGGASQRARELMLLCEAAGYDVVIVETVGVGQSETEVARMVDCFISLQIAGGGDDLQGIKKGLMEVADLIVINKDDGDNHTNVAIARHMYESALHILRRKYDEWQPRVLTCSALEKRGIDEIWHAIIDFKTALTASGRLQQVRQQQSVEWLRKQTEEEVLNHLFANEDFDRYYRQTLLAVKNNTLSPRTGLRQLSEFIQTQYFD
Protein: Alpha-endosulfine (ARPP-19e) (O43768)
Organism: Homo sapiens (Human)
Function: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase greatwall
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
- Misshapen-like kinase 1
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- ATP-binding cassette sub-family C member 8
- Cyclin-dependent kinase 1
Sequence:
MSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE
Protein: LD46723p (Limpet) (Limpet, isoform G) (Limpet, isoform M) (RE64941p) (Q9VVB5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTPSPTKELMSATPTISRRPREEFAEKGAIIREVEDGVRCEQCKSDCPGFAAHDWRKTCQSCKCPREAHAIYQQQTTNVHERLGFKLVSPADSGVEARDLGFTWVPPGVRASSRINRYFEQLPDEMVPRLGSEGACSRERQISYQLPKQDLSLEHCKHLEVQHEASFEDFVTARNEIALDIAYIKDAPYDEHCAHCDNEIAAGELVVAAPKFVESVMWHPKCFTCSTCNSLLVDLTYCVHDDKVYCERHYAEMLKPRCAGCDELIFSGEYTKAMDKDWHSGHFCCWQCDESLTGQRYVIRDDHPYCIKCYENVFANTCEECNKIIGIDSKDLSYKDKHWHEACFLCFKCHLSLVDKQFGAKADKIYCGNCYDAQFASRCDGCGEVFRAGTKKMEYKTRQWHENCFCCCVCKTAIGTKSFIPREQEIYCAGCYEEKFATRCIKCNKVITSGGVTYKNEPWHRECFTCTHCNITLAGQRFTSRDEKPYCAECFGELFAKRCTACVKPITGIGGTRFISFEDRHWHHDCFVCASCKASLVGRGFITDGPDILCPDCAKQKLM
Protein: Serine/arginine repetitive matrix 2 (I3L182)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSG
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit) (Neuronal protein 17.3) (Np17.3) (p17.3) (Q9NX14)
Organism: Homo sapiens (Human)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:31206022, ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000305}. Note=The interaction with BCAP31 mediates mitochondria localization. {ECO:0000269|PubMed:31206022}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 4
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 1
- NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 5
- NADH dehydrogenase 1 alpha subcomplex subunit 8
Sequence:
MAAGLFGLSARRLLAAAATRGLPAARVRWESSFSRTVVAPSAVAGKRPPEPTTPWQEDPEPEDENLYEKNPDSHGYDKDPVLDVWNMRLVFFFGVSIILVLGSTFVAYLPDYRMKEWSRREAERLVKYREANGLPIMESNCFDPSKIQLPEDE
Protein: Protein RETARDED ROOT GROWTH, mitochondrial (Q9C565)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the maintenance of mitochondrial structure. Positive regulator of cell division and endoreduplication but negative regulator of cell expansion in the postembryonic root meristem, thus leading to the promotion of root growth.
Subcellular location: Mitochondrion membrane {ECO:0000305|PubMed:21984726}; Single-pass membrane protein {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:21984726}.
Interaction partners:
- Ribosome biogenesis protein WDR12 homolog
- Homeobox-leucine zipper protein ATHB-21
Sequence:
MGKWRAVAALLLRNQLLNSSKRLNLSSSPCVSKHPTIGLASRFLNFRHFSAFPSPISIYNNDSDSGSNDAYQNYEFGTEAEEALGKIPIKAYFLSTSIDLKAMQAENLCNVVPPTSRSTNYIALKFSDFTPSGIYSLDERESVSNCKFMVVFQYGSAILFNVDDNDVDRYLDIVRRHASGLLTEMRKDDYAVKEKPLLIEEMKGGPDYIVLKTLDTNSIRIIGSVLGQSIALDYSVSQVNKLVEEFADINRSMAKTGTFTMTRKKLFQLVGKANSNIADVILKVGLFERSEIAWREARYAQIYEYLREEYEISQRFGDLDYKLKFIEHNIHFLQEVMQNRQSDLLEWCIIFLLAIENAIGIYEIVRESAGASL
Protein: Ceroid-lipofuscinosis neuronal protein 6 (Protein CLN6) (Q9NWW5)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15265688}; Multi-pass membrane protein {ECO:0000269|PubMed:15265688}. Endoplasmic reticulum {ECO:0000269|PubMed:19941651}.
Interaction partners:
- Bis
- Protein CLN8
- Battenin
- Palmitoyl-protein thioesterase 1
- Major facilitator superfamily domain-containing protein 8
- DnaJ homolog subfamily C member 5
- BTB/POZ domain-containing protein KCTD7
- Tripeptidyl-peptidase 1
- Cathepsin D
- Calmodulin-like protein 4
Sequence:
MEATRRRQHLGATGGPGAQLGASFLQARHGSVSADEAARTAPFHLDLWFYFTLQNWVLDFGRPIAMLVFPLEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSPRTLPRSITYVSIIIFIMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCMWYIPFFLILFMYFSGCFTASKAESLIPGPALLLVAPSGLYYWYLVTEGQIFILFIFTFFAMLALVLHQKRKRLFLDSNGLFLFSSFALTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPWAFYTLHVSSRH
Protein: [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) (A0A3B3ITA8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRAMNIKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVNELRQFVTQLYALPCVLSQTPLLKDLLNRVEDFQQHSQKLLSEETPSAAELQDLLDVSFEFDVELPQLAEMRIRLEQARWLEEVQQACLDPSSLTLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSLLKARPRHSLNSLATAVKEIEEIPAYLPNGAALKDSVQRARDWLQDVEGLQAGGRVPVLDTLIELVTRGRSIPVHLNSLPRLETLVAEVQAWKECAVNTFLTENSPYSLLEVLCPRCDIGLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETASAMATLGEARLREMEALQSLRLANEGKLLSPLQDVDIKICLCQKAPAAPMIQCELCRDAFHTSCVAVPSISQGLRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKFVQDRVGSGLLYSRWQASAGQVSDTNKVSQPPGTTSFSLPDDWDNRTSYLHSPFSTGRSCIPLHGVSPEVNELLMEAQLLQVSLPEIQELYQTLLAKPSPAQQTDRSSPVRPSSEKNDCCRGKRDGINSLERKLKRRLEREGLSSERWERVKKMRTPKKKKIKLSHPKDMNNFKLERERSYELVRSAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTVKDAPSRK
Protein: Complex I intermediate-associated protein 30, mitochondrial (NADH:ubiquinone oxidoreductase complex assembly factor 1) (Q9VAI1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9Y375}.
Interaction partners:
- Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex assembly factor 3
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- Complex I assembly factor TIMMDC1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- GH23780p
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH-ubiquinone oxidoreductase chain 2
Sequence:
MNSLLRQGLRLGCCLPAVQQQIHTTAVHRTFWEREKKSGYKTKLPEPSKKQMIMDGLRDLKEEMKLWRQEVKEQFESDPILVFRPGETDVVFDFKAPDVLDKWTVTTDADHGEGKSTATLELSAAGAGLFHGQVNSDHTKDGIIKRTGYANIRTKRVRKSFKRETTYDWTQYNMLVMKVRGDGRSYLINLHTEGYFDLMWNDIYHYVLYTRGGPHWQIAKIPFSKFFLSSKGRVQDRQGAIPLNRVTHFGFSVAAKKGMDGPFGLEIDYVGLEYDPSHREEFAYEMYQTPKYIVAT
Protein: MUTator (Q22061)
Organism: Caenorhabditis elegans
Interaction partners:
- MUTator
- RNA helicase
- PAP-associated domain-containing protein
- Exonuclease mut-7
- Zc3h12a-like Ribonuclease NYN domain-containing protein
- Zc3h12a-like Ribonuclease NYN domain-containing protein
- RNase NYN domain-containing protein
- RNA-directed RNA polymerase
- SH2 domain-containing protein
Sequence:
MDNSNGIGICSMGVVNAFDLDGLGNARRSCFSVKEARAHNPEWGPAASREEVAYVRSSETGSLQITRKLMKFSISGRRGYSPWRTLQDALYCSLGRFHNGEHLFCIHSGPNHEFYYGQPILHSIDRFRSHRKPFPRCIIITTDGKRSKSVMRGLLNKRRSSNSTRPNTHITNLDTTELSNEFMTSNRSRVFIGSFKKIKEYIDKLKNEMEQLDDFISVLRFVIINNAEKLKGNSEFADSLGRLAQTFESSLTRFIFAYHFSSSVASLTETLEFCKGKMERPVLIEADNPRVRDVFSNIECKLVRPISEIASLLPTQESTLENNNISPAIVSQYLTESTQKLKILTMLIKKERDARAADNGRSGRRDKPRRERILVITRTTETCIRVMMYLRLKMQTLAVNLRYNIHKITTCDSEEDVEKRNFEFRTGNLDVLVIDWRSIRAVHRGAVDTIVMFDSPHPLYFQTIMETELQNLASIIGVKLKLYMIIDQNKDFRLVREYLKFLECNKTRAPTWFRDLYQKYLADRQSRTTAAVATATSAVPV
Protein: Homeobox protein notochord (Q5TIS6)
Organism: Mus musculus (Mouse)
Function: Transcription factor that controls node morphogenesis. Acts downstream of both FOXA2 and Brachyury (T) during notochord development. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Hepatocyte nuclear factor 3-beta
- T-box transcription factor T
- Hepatocyte nuclear factor 3-alpha
- Transcriptional enhancer factor TEF-4
- Transcriptional coactivator YAP1
Sequence:
MSSPAPSGTQVQPGSLRPCPGAVSPVVPRRLARGRLESSFSVEAILARPKTRELAATSLPLSTCTSLNLLGAVSQYGVLPWVCSTGSWLPAYLSVGVYPLCSMSCVPGLNVTHHQQGLRLTGSELPYCLGPLKWAPTVDLRDHGTERHTKRVRTTFNLQQLQELEKVFAKQHNLVGKERAQLAARLHLTENQVRIWFQNRRVKYQKQQKLKLPSSSVMEEPSSSSDGNIQSEDAELGIGS
Protein: Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (F1D8S3)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ
Protein: Putative flavin-containing monooxygenase (Q83XK4)
Organism: Methylophaga aminisulfidivorans
Interaction partners:
Sequence:
MATRIAILGAGPSGMAQLRAFQSAQEKGAEIPELVCFEKQADWGGQWNYTWRTGLDENGEPVHSSMYRYLWSNGPKECLEFADYTFDEHFGKPIASYPPREVLWDYIKGRVEKAGVRKYIRFNTAVRHVEFNEDSQTFTVTVQDHTTDTIYSEEFDYVVCCTGHFSTPYVPEFEGFEKFGGRILHAHDFRDALEFKDKTVLLVGSSYSAEDIGSQCYKYGAKKLISCYRTAPMGYKWPENWDERPNLVRVDTENAYFADGSSEKVDAIILCTGYIHHFPFLNDDLRLVTNNRLWPLNLYKGVVWEDNPKFFYIGMQDQWYSFNMFDAQAWYARDVIMGRLPLPSKEEMKADSMAWREKELTLVTAEEMYTYQGDYIQNLIDMTDYPSFDIPATNKTFLEWKHHKKENIMTFRDHSYRSLMTGTMAPKHHTPWIDALDDSLEAYLSDKSEIPVAKEA
Protein: Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9) (Q9WV56)
Organism: Mus musculus (Mouse)
Function: Potent circulating inhibitor of angiogenesis (By similarity). Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9UK05}.
Interaction partners:
- Bone morphogenetic protein receptor type-2
- Activin receptor type-1-like
- Activin receptor type-2B
- Activin receptor type-1
- Endoglin
- Activin receptor type-2A
- TGF-beta receptor type-1
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein 10
- Bone morphogenetic protein receptor type-1B
Sequence:
MSPGAFRVALLPLFLLVCVTQQKPLQNWEQASPGENAHSSLGLSGAGEEGVFDLQMFLENMKVDFLRSLNLSGIPSQDKTRAEPPQYMIDLYNRYTTDKSSTPASNIVRSFSVEDAISTAATEDFPFQKHILIFNISIPRHEQITRAELRLYVSCQNDVDSTHGLEGSMVVYDVLEDSETWDQATGTKTFLVSQDIRDEGWETLEVSSAVKRWVRADSTTNKNKLEVTVQSHRESCDTLDISVPPGSKNLPFFVVFSNDRSNGTKETRLELKEMIGHEQETMLVKTAKNAYQVAGESQEEEGLDGYTAVGPLLARRKRSTGASSHCQKTSLRVNFEDIGWDSWIIAPKEYDAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISILYKDDMGVPTLKYHYEGMSVAECGCR
Protein: Peroxisomal biogenesis factor 39 (Q5I0X4)
Organism: Homo sapiens (Human)
Subcellular location: Peroxisome {ECO:0000305|PubMed:37160800}.
Interaction partners:
- Peroxisomal targeting signal 2 receptor
- 3-ketoacyl-CoA thiolase, peroxisomal
Sequence:
MERPRSPQCSAPASASASVTLAQLLQLVQQGQELPGLEKRHIAAIHGEPTASRLPRRPKPWEAAALAESLPPPTLRIGTAPAEPGLVEAATAPSSWHTVGP
Protein: Paraflagellar rod component (Q385U3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAKKGKKNSAPQLVAPEPVADELEVDILWDAVKEVDDKPPFMDGTHLDATRALFKLEKTGRGAPDVPHNFFQLRERNLSVVRARDRFVLAEQRLKERMEVDEGLQDDDQCFLSLKQSEGEEYLRERRAAMENIAGVKSALVEDQLGLITRMEEAAEDFFRGWNDLLEEVTALATGDSKVSAAFEEKRTLTKTFREAEEQYFHDHGEHVVGIREMRRETKRQQDEMLQSMVTRLGAGVVEMARLSVEELEDKAAQQEETTRLISELMKVQGKSTVLEKQTIAINEHRATLQRLIDLEVQKQEFCILRQKQIESDLKTLSETVKHNNEQLLLLSSNATPCQEYKKLLPMIPTSPNTISNLTNVQDKSLLLLTVEAKRQLEGLDAELKTLKDELATLRRRHIVHLSGKYKPTATDGPLSAMKKTAELGIETTSAIRSAVLNSLEQVCRCLGCTEDAEAPGDSLERLFSITDVEERKAVQLYVSRCISKLFSSECPTALPVPFPRSSKGIQWDMLPSH
Protein: ATP phosphoribosyltransferase (ATP-PRT) (ATP-PRTase) (EC 2.4.2.17) (P46586)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Histidine biosynthesis trifunctional protein
- histidinol-phosphate transaminase
- Imidazole glycerol phosphate synthase hisHF
- Imidazoleglycerol-phosphate dehydratase
- 1-
- DNA repair protein
- Multifunctional tryptophan biosynthesis protein
- Tryptophan synthase
- ribose-phosphate diphosphokinase
- Ribose-phosphate pyrophosphokinase 1
Sequence:
MDLVNHLPDRLLFAVPKKGRLYEKCCNLLSGADIQFRRSNRLDIALSTNLPIALIFLPAADIPVFVGEGNCDLGITGLDQIKEAEQFDNIEDLLDLKFGSCKLQIQVPADGEYEKPEQLVGKKIVSSFTKLSTDYFKQLSDKPTNIRYVGGSVEASCALGVADAIVDLVESGETMKAAGLKAIETILETSAHLISSKKSKFPEMVNIIVQRLQGVLAAQEYVLCNYNAPKSIQAKCLTITPGRRAATVSTLDKHSDDEEDWVAISSMVNRKEIGNVMDELKKAGATDILVLEISNCRV
Protein: Ventral anterior homeobox 2 (Q9UIW0)
Organism: Homo sapiens (Human)
Function: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGDGGAERDRGPARRAESGGGGGRCGDRSGAGDLRADGGGHSPTEVAGTSASSPAGSRESGADSDGQPGPGEADHCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQSRDLEKRASSSASEAFATSNILRLLEQGRLLSVPRAPSLLALTPSLPGLPASHRGTSLGDPRNSSPRLNPLSSASASPPLPPPLPAVCFSSAPLLDLPAGYELGSSAFEPYSWLERKVGSASSCKKANT
Protein: Signiferin-1 (P86123)
Organism: Crinia deserticola (Desert froglet)
Function: Induces mouse splenocyte proliferation and guinea pig smooth muscle contraction through binding to CCK-BR.
Subcellular location: Secreted {ECO:0000269|PubMed:18601958}.
Interaction partners:
Sequence:
RLCIPYIIPC