wanglab/gogpt-training-data huggingface dataset:
Protein: Syntenin-1 (Syndecan-binding protein 1) (Q9JI92)
Organism: Rattus norvegicus (Rat)
Function: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Subcellular location: Cell junction, focal adhesion {ECO:0000250|UniProtKB:O00560}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O00560}. Cell membrane {ECO:0000250|UniProtKB:O00560}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00560}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00560}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00560}. Nucleus {ECO:0000250|UniProtKB:O00560}. Melanosome {ECO:0000250|UniProtKB:O00560}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O00560}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O00560}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:O00560}. Membrane raft {ECO:0000250|UniProtKB:O00560}. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (By similarity). {ECO:0000250|UniProtKB:O00560}.
Interaction partners:
- Programmed cell death 6-interacting protein
- CD63 antigen
- Neurofascin
- Syndecan-4
- CD81 antigen
- CD9 antigen
- Tumor susceptibility gene 101 protein
- Syndecan-1
- Ephrin-B1
- Receptor protein-tyrosine kinase
Sequence:
MSLYPSLEDLKVDKVIQAQTASSANPASQAFFLNVVDSAAFPPGGNLYPKLYPELSQYMGLSLSEAEICENMPVVSGAPTQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKDQDGKIGLRLKSVDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEINGQNVIGLKDAQIADILSTAGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV
Protein: Indole-3-acetic acid-amido synthetase GH3.2 (EC 6.3.2.-) (Auxin-responsive GH3-like protein 2) (AtGH3-2) (Protein YADOKARI 1) (Q9SZT9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin. Strongly reactive with Glu, Gln, Trp, Asp, Ala, Leu, Phe, Gly, Tyr, Met, Ile and Val. Little or no product formation with His, Ser, Thr, Arg, Lys, or Cys. Also active on pyruvic and butyric acid analogs of IAA, PAA and the synthetic auxin naphthaleneacetic acid (NAA). The two chlorinated synthetic auxin herbicides 2,4-D and 3,6-dichloro-o-anisic acid (dicamba) cannot be used as substrates.
Interaction partners:
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
- CF9 protein
- Receptor-like protein 30
- Auxin transporter protein 1
- Receptor-like protein 42
- Probably inactive leucine-rich repeat receptor-like protein kinase At5g48380
- U-box domain-containing protein 20
- Receptor like protein 23
Sequence:
MAVDSPLQSRMVSATTSEKDVKALKFIEEMTRNPDSVQEKVLGEILTRNSNTEYLKRFDLDGVVDRKTFKSKVPVVTYEDLKPEIQRISNGDCSPILSSHPITEFLTSSGTSAGERKLMPTIEEDLDRRQLLYSLLMPVMNLYVPGLDKGKGLYFLFVKSESKTSGGLPARPVLTSYYKSDHFKRRPYDPYNVYTSPNEAILCSDSSQSMYAQMLCGLLMRHEVLRLGAVFASGLLRAISFLQNNWKELARDISTGTLSSRIFDPAIKNRMSKILTKPDQELAEFLVGVCSQENWEGIITKIWPNTKYLDVIVTGAMAQYIPTLEYYSGGLPMACTMYASSESYFGINLKPMCKPSEVSYTIMPNMAYFEFLPHNHDGDGAAEASLDETSLVELANVEVGKEYELVITTYAGLYRYRVGDILRVTGFHNSAPQFKFIRRKNVLLSVESDKTDEAELQKAVENASRLFAEQGTRVIEYTSYAETKTIPGHYVIYWELLGRDQSNALMSEEVMAKCCLEMEESLNSVYRQSRVADKSIGPLGDTCGTERYV
Protein: Ornithine carbamoyltransferase subunit F (OTCase-2) (EC 2.1.3.3) (P06960)
Organism: Escherichia coli (strain K12)
Function: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- N-acetyl-gamma-glutamyl-phosphate reductase
- Argininosuccinate synthase
- Acetylornithine deacetylase
- Amino-acid acetyltransferase
- Carbamate kinase-like protein YqeA
- Acetylglutamate kinase
- Carbamoyl phosphate synthase large chain
- Carbamate kinase
- Carbamate kinase-like protein YahI
- Argininosuccinate lyase
Sequence:
MSDLYKKHFLKLLDFTPAQFTSLLTLAAQLKADKKNGKEVQKLTGKNIALIFEKDSTRTRCSFEVAAFDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAQYAGVPVWNGLTNEFHPTQLLADLMTMQEHLPGKAFNEMTLVYAGDARNNMGNSMLEAAALTGLDLRLLAPKACWPEESLVAECSALAEKHGGKITLTEDVAAGVKGADFIYTDVWVSMGEAKEKWAERIALLRGYQVNAQMMALTDNPNVKFLHCLPAFHDDQTTLGKQMAKEFDLHGGMEVTDEVFESAASIVFDQAENRMHTIKAVMMATLGE
Protein: ELAV-like protein (Q6GQM6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
METQLSNGPSCTSSNGPNSVSNTCTSPVEMPNGSEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYMEPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQFGRIITSRILVDQVTGVSRGVGFIRFDRRVEAEEAIKGLNGQKPPGATEPITVKFANNPSQKSSQALLSHLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKSRFSPMTIDGVTSLAGINLPAHAGTGWCIFVYNLAPDADENVLWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAVAIASLNGYRLGDRVLQVSFKTNKTHKA
Protein: E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (xNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) (Q1L721)
Organism: Xenopus laevis (African clawed frog)
Function: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (By similarity). Together with nlk.2, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with ube2k. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
Subcellular location: Chromosome {ECO:0000250|UniProtKB:Q8WVD3}. Note=Recruited at DNA damage sites. Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers. {ECO:0000250|UniProtKB:Q8WVD3}.
Interaction partners:
Sequence:
MAEAMSCSSEITEEFLCPVCQEILQTPVRTQTCRHVFCRKCFMLAMKSGGAYCPLCRGPVNKSERSAPVRATDIDLEMRMLSGGCMYCGKMMKLHYMKLHYKSCRKYQEEYGLSPKNVTIQTGQNSTKCQEPKYKCPLCSEHNLNQRSLLEHCNNVHYYEEVEMVCPICATLPWGDPIQTTGNVIAHLNARHQFNYQEFMNINIDEEAQFQIAVANSYKISR
Protein: Superoxide dismutase (EC 1.15.1.1) (A0A384NL29)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
Protein: MAT2 proteinMating type HMG-box protein (C8VAU1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Alpha box domain-containing protein
Sequence:
MAAVSIAMKSPTQSPDSITELLWKDALRHLGSTNDEVLLPTNVVDIIGQDNVEKIKSRLSALLGAPVVSFVDESINALRVLRTPTFSGSSISVASPSRALDSWPSEPPNKPRPASMKPAKIPRPPNAFILYRQHHYPKVKEARPDLSNNEISVIIGKKWRAEPEEGKLHFKNLAEEFKKKHAEEYPDYQYTPRKPSEKKRRAASRISPKNSKRTVALENPGSMTAPSSNVFTPQMYPGIQNGQLAGAGYIGYLDGLNSMVNTGGLTDEPTNFGTNAFNSLFQQPQSDYGRTALFPQLEFAGPSLGDSLEFPEFAADYF
Protein: Multiple C2 domain and transmembrane region protein 11 (O49435)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29259105}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Indole-3-glycerol phosphate synthase, chloroplastic
- NC domain-containing protein-like protein
- N-
- Wall-associated receptor kinase-like protein
- N-
- indole-3-glycerol-phosphate synthase
- AT4g00920 protein
- N-
- Uncharacterized protein At4g00950
- ATPase, F1 complex, OSCP/delta subunit protein
Sequence:
MAVNGTGNGTGDGDFSLKETSPNIGNGGVNGGEKLTSSFDLVEAMHFLYARIVRARALPVNDSFVAVKIGSYKGRTKQILNSNPNPEFHETFAFTKTRLQGDILEVVVRNRDNPNEDDIVGKCKFDVAEIPTRVPPDSPLAPQWYRLEDRNGVKIGGEIMVSVWIGTQADEVFSEAWHSDSASVTGENVVNTRSKVYLSPRLWYLRVNVIEAQDLVLLHPNRINPEILIKGFLGNVVVRSRISQTKSVSPVWNEDMMFVAVEPFDDSLILSVEDKVGPREECLGRCEIKLSQVERRVLPGPVPSLWYNVEHIGETGEGRRFAGRIHLRVSLDGGYHVLDESIQYSSDYRASAKLLWTPPIGVLELGVLNATGLMPMKSRGGRGTTDAYCVAKYGTKWVRTRTIVDTFDPKWNEQYTWEVYDPYTVITIGVFDNLKLFGAGNENRLINDSRIGKIRIRLSTLVTSKIYTHSYPLMVLKPDGVKKMGEIQLAVRFTATSMMDMLQKYTEPLLPEMHYISPLSIYQLDSLRHQATHILCINLGRNEPALGRDVVEYMLDVGSNIWSLRRGRANFERLVSFFDGWIDAWKWFDEICKWKSPVTSVLVHIVCLFVVFLPKYCVFSMLLYCFVFGLYRFGLRPRHPPHMDIKLSKADSALPDELDEEFDVFPSSKSGDVLKRRYDRLRGIAGRMMIVLGDLATQGERVKSLLSWRDPRATSLFLTFCFVSCGVICFVSMKLLLTFLAFYVMRHPRVRVFDIPSIPQNFFRRLPSRADSIL
Protein: Synaptotagmin-like protein 5 (Q8TDW5)
Organism: Homo sapiens (Human)
Function: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Ras-related protein Rab-27A
- Ras-related protein Rab-27B
- Ras-related protein Rab-3A
Sequence:
MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETEESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLRSSMGKCRL
Protein: CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (F6NXI9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q96Q11}. Cytoplasm {ECO:0000250|UniProtKB:Q96Q11}. Nucleus {ECO:0000250|UniProtKB:Q96Q11}.
Interaction partners:
- Adipocyte plasma membrane-associated protein
- Uncharacterized protein LOC570908
- Holocarboxylase synthetase) ligase).
- Bifunctional glutamate/proline--tRNA ligase
- Oligoribonuclease, mitochondrial
- Pseudouridylate synthase 1 homolog
- Vacuolar protein sorting-associated protein 29
- Tyrosine--tRNA ligase, cytoplasmic
- ATP synthase F1 subunit delta.
Sequence:
MWAKLFLRPSFVNRVHLTWSCRALLTMQLKTKEFESLFTDGLVGLAEIFQKNQFELRIAGGAVRDLLSGKRPEDVDFATTATPEEMKSMFQTAGVRMINNKGEKHGTITARLHEENFEVTTLRVDVQTDGRHAEVEFTTDWQKDAERRDLTINSMFLGLDGTLYDYFQGYEDLKNRKVRFVGSASLRIQEDYLRILRYFRFYGRVAAEPGQHEPETLEAIRENARGLAGISGERIWVELKKMLVGNHAGHLLELVYELGLAQYTGLPADGDVEEMKQVWQRAHVSSPKPMTVLAALFRKQADVENLDQRLKVSREEKNLGLFLVKYRRDLVKGHDEHDTMKPYTDFITDSREPDTQSKVLELLKYQGENKLLDELRRWSIPRFPVSGHDLRKLGYTSGKEIGTILQELRDMWKKSRYQMSKDELLSTLSQS
Protein: Protein PES4 (DNA polymerase epsilon suppressor 4) (P39684)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Eukaryotic initiation factor 4F subunit p130
- Eukaryotic initiation factor 4F subunit p150
- RNA-binding protein MIP6
- PAB1-binding protein 1
- ATP-dependent helicase NAM7
Sequence:
MYSISNKKPSILSMVPLNILKNQDLKVKKDQEKKISFNPVVTPIRPDDYHEKTSRSSSSSHSDSPEFLRINNNKSGHKNGKLKSFESKKLVPLFIGDLHETVTEETLKGIFKKYPSFVSAKVCLDSVTKKSLGHGYLNFEDKEEAEKAMEELNYTKVNGKEIRIMPSLRNTTFRKNFGTNVFFSNLPLNNPLLTTRVFYDTFSRYGKILSCKLDSRKDIGFVYFEDEKTARNVIKMYNNTSFFGKKILCGIHFDKEVRSVPNFETQKSRLDAETIIEKEQSLNEKHSKGNDKESKNIYSSSQNSIFIKNLPTITTRDDILNFFSEVGPIKSIYLSNATKVKYLWAFVTYKNSSDSEKAIKRYNNFYFRGKKLLVTRAQDKEERAKFIESQKISTLFLENLSAVCNKEFLKYLCHQENIRPFKIQIDGYDENSSTYSGFIKFRNFEDATRIFNFLNNRLVGGSIVTTSWERQNNAPKYHDGYGMRNIHTSSHPQITPYYQYSHANSLNSPHMRDLSSMNSSTRSLIKNKNFNKKVLETFEKQVRRGIDFMRFPSATRDENVHGIAEYIFDTYWNRDVLILDKFLSLLNSSPYHEGVLQKQIEEAASSLGFKR
Protein: Protein U90 (Q77PU6)
Organism: Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Interaction partners:
Sequence:
MESAKDTTSTSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSYSSNVEEGASDEFKTLVAQSVGNCIQSIGASVKAAMKQEQSNMEDNLINSAGLLTLHRSMLERLVLEQLGQLININLLSSASSQFVSCYAKMLSGKNLDFFNWCEPRFIVFACDKFDGLVKKIASESRDLLMDLKANMNNQFITALKNIFSKAYVALDSGKLNMVATSLLLMAHNKEMSNPEISNKEFCKQVNLLKQELLESRNEIIENHVKNMKMFQEFANKQMNQIFMDNCDKTFLKIHINCKNLITAAKNIGIAVLQSIVLCSNEFSWQYLKPRRHQFKITMMNMITHACECIETIYDDTGLIKPLTSSDIMEGYIAINKNRESSICDLNIDPSESILLELADFDEHGKYSEESSIESIHEDDDNVDYLKYMEVQSPTDNNIPTPSKNNESPTRQKLTNIHEKDVGKMYPDTPSPDVPGKSKEAKTFIEYSRQIGKEQTSPNCVCTASVTDLGGPDNFKSITGLESGKHFLIKKLLETQPDSVVVETGSGQQDILAYSPDKRSQTKEWIQEKGSNSKCTETLPGMTFTNSATPVKSHGAIQDTLNPESKLDKEMEAVESLVNLCDGFHDNPLISEMITFGYETDHSAPYESESDNNDETDYIADCDSTVRTNNIHMNNTNENTPFSKSLYSPPEVTPSKEDHKTEKIVAVSQKCKSKKRTAKRKNVPIKPSKSKKIKLDRLPETTNVIVISSESEDEEDGNNIIDKSMLEKTIKSEPNSESSSESDDCTSEDNYLHLSDYDKVINNGHCQSKGFPSPVFTIPIRSMPGTHDIRNKFVPKKHWLWFMRKTHKVDNCVIHSSAKMNVKNDSDVTEANHCFINHFVPIKTDDEEYEKENVSYTYSKIQDSKTDLEDITPTKKLITEMVMENFMDLTDIIKHGIAKHCQDLSSKYTVITHTACEKNLNVANSQNLVTAETQIFDPQGTGNNSPILNIINDTTCQNDENRCTEGTSNDNEKCTIRSDCNSDKMEVFKLDGYPSDYDPFEENAQIY
Protein: Inner membrane protein YcfZ (P75961)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Inner membrane protein YmfA
- Putative oxidoreductase YceM
Sequence:
MKKFIILLSLLILLPLTAASKPLIPIMKTLFTDVTGTVPDAEEIAHKAELFRQQTGIAPFIVVLPDINNEASLRQNGKAMLAHASSSLSDVKGSVLLLFTTREPRLIMITNGQVESGLDDKHLGLLIENHTLAYLNADLWYQGINNALAVLQAQILKQSTPPLTYYPHPGQQHENAPPGSTNTLGFIAWAATFILFSRIFYYTTRFIYALKFAVAMTIANMGYQALCLYIDNSFAITRISPLWAGLIGVCTFIAALLLTSKR
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q57Y75)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MLGDRKTQTTRLLIAILVLLTALPQWVVPAAHMGLLKATWQPLCALTKELDEVPGEALQEVMAILSKASELEKEAMMLKIYSALTESESEAKKATTVAAHMRRLAHSQRQYFMTIDAQKFLAASKASAYAKGRLDEFLQVAGSMKDSSNRGCLLAGSNQNGLKLTDGALDGVQCKNSASQVAATTRATKTITAAGISGPIHGQESSNRIQHSANECRLFGKTHANGLGHTAALENPKLVWAGGYITIDTSSGDDGKVTLTQLTPAGTQTRPEAKPWQDCIEAVGAMPTAGSPAYTNDTAVLATSESAADLFGRVQKNIEDGTLSNTKTEITAMFGDQPEVQVNKLLSNAANYQLKEKIGGKNKGTKLNEIGTAAELEAVLAAVDIKLIETRSKLIKQLNEEKQKKGGDDTTKTSETDETCQAKGTGDKCTSPCKEVEEGGKKKCTLDKEAKQTAEGAAKQEGKDGKTVDCSKLYTQEKCEKANEGQATKVCGWKGENTDGSDKSGYKCRNGSFLVKKQFALSVVSAAFVGFIEFKSSKDNTNFRLIF
Protein: Dynein light chain roadblock-type 2 (Dynein light chain 2B, cytoplasmic) (Q9DAJ5)
Organism: Mus musculus (Mouse)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Dynein light chain 2, cytoplasmic
- Cytoplasmic dynein 1 intermediate chain 1
- Dynein light chain Tctex-type 3
- Dynein light chain Tctex-type 1
- Cytoplasmic dynein 2 intermediate chain 2
- Dynein light chain Tctex-type protein 2B
- Dynein light chain Tctex-type protein 2
- Dynein light chain Tctex-type 2A1
- Dynein light chain 1, cytoplasmic
- Cytoplasmic dynein 2 light intermediate chain 1
Sequence:
MTEVEETLKRIQSHKGVIGTMVVNAEGIPIRTTLDNSTTVQYAGLLHQLTMKAKSTVRDIDPQNDLTFLRIRSKKHEIMVAPDKEYLLIVIQNPCE
Protein: Catabolite control protein A (Q03AX7)
Organism: Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441) (Lactobacillus paracasei)
Interaction partners:
- Phosphocarrier protein HPr
- PTS system sucrose-specific EIIBCA component
- PTS system sucrose-specific EIIBCA component
- PTS system sucrose-specific EIIBCA component
- PTS system beta-glucoside-specific IIC component, Glc family / PTS system beta-glucoside-specific IIA component, Glc family / PTS system beta-glucoside-specific IIB component, Glc family
- Glutamate synthase large subunit
- Xaa-Pro aminopeptidase, Metallo peptidase, MEROPS family M24B
- Pyruvate kinase
- Sucrose-6-phosphate hydrolase
Sequence:
MEKQTITIYDVAREANVSMATVSRVVNGNPNVKPATRKKVLEVIERLDYRPNAVARGLASKKTTTVGVIIPDVTNMFFSSLARGIDDVATMYKYNIILANSDENNQKEVTVLNTLLAKQVDGLIFMGHELTDSIRAEFSRSKTPVVLAGSIDPDEQVGSVNIDYVAAVEEATRQLLESGNKRVALATGSLTHPINGQFRLKGYKQALEKAGVAYDESLIFENEPSYQAGLALFDKLQKVGATAVIAGDDELAVGLLDGAIDKGVKVPDDFEIITSNNTKLTEMTRPQLTSIDQPLYDIGAVAMRLLTKMMNKEEIEEKTVMLGFDILKRGSTK
Protein: Zinc finger protein CONSTANS-LIKE 9 (Q9SSE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00357}.
Interaction partners:
- Two-component response regulator-like APRR1
- B-box zinc finger protein 32
- MADS-box protein SOC1
- Protein EARLY FLOWERING 4
- Adagio protein 3
- Protein LHY
- Protein EARLY FLOWERING 3
- B-box domain protein 31
Sequence:
MGYMCDFCGEQRSMVYCRSDAACLCLSCDRSVHSANALSKRHSRTLVCERCNAQPATVRCVEERVSLCQNCDWSGHNNSNNNNSSSSSTSPQQHKRQTISCYSGCPSSSELASIWSFCLDLAGQSICEQELGMMNIDDDGPTDKKTCNEDKKDVLVGSSSIPETSSVPQGKSSSAKDVGMCEDDFYGNLGMDEVDMALENYEELFGTAFNPSEELFGHGGIDSLFHKHQTAPEGGNSVQPAGSNDSFMSSKTEPIICFASKPAHSNISFSGVTGESSAGDFQECGASSSIQLSGEPPWYPPTLQDNNACSHSVTRNNAVMRYKEKKKARKFDKRVRYASRKARADVRRRVKGRFVKAGEAYDYDPLTPTRSY
Protein: Photoactivated adenylate cyclase subunit alpha-like protein ST- (P84739)
Organism: Euglena gracilis
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:16121285}.
Interaction partners:
Sequence:
MYNRVYKERQEIRTIQGLEASGQFQTASNITDIQIYSINVTPTMSKGGETGETQLRRLMYLSASTEPEKCNAEYLADMAHVATLRNKAIGVIRFLLYSSPFFFQVIEGTDEDLDFLFAKISADPRHERCIVLANGPCTGRMYGEWHMKDSHIDNITNNPAIKTILFQIARSFTSMWSYLPKNAANMLLLGKNPNKQGPEPRSVVLTFIYLVEFSSILAHPGLTEQCADILAAFVEASVRNCEGTWGLVAKFITGTCVAYWPINRAEDALVGLQQLSEDLAVLRSYQPPGSALSRIYSRRGVHYGRALLCNAGFRKADFTLLGDCINTASRITSLSVKLKVPLLLSFEVRCLLGDEMREELERSALHKVKGRDKPVQVYQFNAPELDSALVRAKIEQFNPGRYRALCPVKPYESLHPAQRPPIFDDTPRENQPKLSQVQRRDSLVDRLSLIAKLAFPSSMMAGGEGQLITLTYISQAAHPMSRFDLASIQRIAFARNESSNITGSLLYVSGLFVQTLDDPKGAVESLYLKIRQDKRHKDVVAVFMAPIDERVYGTPLDMTSATEEMLATFPPLQDVLSQLAKSFISLETYVPSTVVRYLTAGNNPRNLQPVSVEVVMLATDICSFTPLSEKCSLTEVWTICNTFIDACTSAICNEGGEVIKLIGDCVTAYFAPTGADNAVHACQEIVSFSAQLRDAFHDVLDCRSVVACGVGLDFGQVIMAQCGSLRLTEFVVAGEVSARVMAVEALTREAGRAIVITEPVSDRLSAKLRDTGIVPCQEGLHAVLLWYPGPRMGIGCANHQEDHLRVPRRPGPGRHEEGGRRHQRPGPGRPRRGHPFLPQGSTTRPHQFSVQLHPLPKLGTGSSDGGIGVSLHVYSAGRYRQQLHRRQIAAGGQRRSVGPGQDVARATRAHACDAGHQAPDQPANAQYERQFRGGQQRWRTCGIVHSNAFVTGVGLVQQPWLDEGHRPEAPHQSLHPGPGDPSEQHPHRPNRATEPGLLVARQPAVCLHRPEGFAQICTF
Protein: Large ribosomal subunit protein eL31 (60S ribosomal protein L31) (Q9URX6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein eL8
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein eL38A
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL22
Sequence:
MANTKKSAINQVVTRDYTIHMHKRLYGVSFKKRAPRAIKEIVAFAQKHMQTKEVRVDPSLNKEVWKRGIRNVPHRLRLRLSRKRSDEDDKALYTYVQAVDVANPKMETTVVEE
Protein: Spliceosome-associated protein CWC15 homolog (Q9P013)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
Interaction partners:
- Pre-mRNA-splicing factor SPF27
- Protein BUD31 homolog
- SNW domain-containing protein 1
- Beta-catenin-like protein 1
- Pre-mRNA-splicing factor RBM22
- Cell division cycle 5-like protein
- U2 small nuclear ribonucleoprotein A'
- Crooked neck-like protein 1
- Pre-mRNA-processing-splicing factor 8
- 116 kDa U5 small nuclear ribonucleoprotein component
Sequence:
MTTAARPTFEPARGGRGKGEGDLSQLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRNRDFRRELEERERAAAREKNRDRPTREHTTSSSVSKKPRLDQIPAANLDADDPLTDEEDEDFEEESDDDDTAALLAELEKIKKERAEEQARKEQEQKAEEERIRMENILSGNPLLNLTGPSQPQANFKVKRRWDDDVVFKNCAKGVDDQKKDKRFVNDTLRSEFHKKFMEKYIK
Protein: Hsp90 co-chaperone AHA1 (Activator of Hsp90 ATPase protein 1) (Q12449)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity. Binding to HSP82 promotes a conformational switch in the catalytic loop of HSP82, facilitating the interaction of the catalytic 'Arg-380' with ATP in the N-terminal nucleotide-binding domain. Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase CPR6
- ATP-dependent molecular chaperone HSC82
- ATP-dependent molecular chaperone HSP82
- Heat shock protein STI1
- Hsp90 co-chaperone HCH1
- Co-chaperone protein SBA1
- Hsp90 co-chaperone Cdc37
- Peptidyl-prolyl cis-trans isomerase CYP7
- Protein SIS1
- Mitochondrial protein import protein MAS5
Sequence:
MVVNNPNNWHWVDKNCIGWAKEYFKQKLVGVEAGSVKDKKYAKIKSVSSIEGDCEVNQRKGKVISLFDLKITVLIEGHVDSKDGSALPFEGSINVPEVAFDSEASSYQFDISIFKETSELSEAKPLIRSELLPKLRQIFQQFGKDLLATHGNDIQVPESQVKSNYTRGNQKSSFTEIKDSASKPKKNALPSSTSTSAPVSSTNKVPQNGSGNSTSIYLEPTFNVPSSELYETFLDKQRILAWTRSAQFFNSGPKLETKEKFELFGGNVISELVSCEKDKKLVFHWKLKDWSAPFNSTIEMTFHESQEFHETKLQVKWTGIPVGEEDRVRANFEEYYVRSIKLTFGFGAVL
Protein: Fibroblast growth factor (FGF) (Q8VI81)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Klotho beta
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor
- Fibroblast growth factor receptor
- Klotho
- Fibroblast growth factor receptor 1
- Pro-epidermal growth factor
- Vascular endothelial growth factor receptor 2
- Albumin
- Vascular endothelial growth factor receptor 3
Sequence:
MARKWSGRIVARALVLATLWLAVSGRPLVQQSQSVSDEGPLFLYGWGKITRLQYLYSAGPYVSNCFLRIRSDGSVDCEEDQNERNLLEFRAVALKTIAIKDVSSVRYLCMSADGKIYGLIRYSEEDCTFREEMDCLGYNQYRSMKHHLHIIFIKAKPREQLQGQKPSNFIPIFHRSFFESTDQLRSKMFSLPLESDSMDPFRMVEDVDHLVKSPSFQK