wanglab/gogpt-training-data huggingface dataset:
Protein: Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) (Q9D898)
Organism: Mus musculus (Mouse)
Function: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 1A
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2
- Actin, cytoplasmic 2
- Actin nucleation-promoting factor WASL
- Actin nucleation-promoting factor WAS
- Actin-related protein 3
Sequence:
MARNTLSSRFRRVDIDEFDENKFVDEHEEAAAAAGEPGPDPCEVDGLLRQGDMLRAFHAALRNSPINTKNQAVKERAQGVVLKVLTNFKSSEIEQAVQSLDRNGIDLLMKYIYKGFEKPTENSSAVLLQWHEKALAVGGLGSIIRVLTARKTV
Protein: Uncharacterized protein (Q583Y9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
Sequence:
MEIEGHETEAMPTATKYDPTECGRTEGSHITQINVTVQGRGRPPTVPEGASVEKPKSILKNTTGTSTTSAEASRKRTVRFGGSDTFEAAPYFSTPESNSEEGSVDSRGGGDNIGAAAAPRAGKERHDDDDDQLETGSNTSEPTSPRLGAIGWVPLAVQRPPAGEHRKGKQGNKPTEGKRNEMASWEMPSTHQGGKGKGEGSLLDVSVSESTLSPGSEKSLIAAADDENNIEKHRKDVKAVDLVAKSRTSGKPPRGEVLTVTGLSLDKIPIQESRGTDYKENSTDDLPRLFYPTPRPQKDFNNAEEEKPPLRHRDSHTDGDDGDKPGTVSAELLDHLQRKSGVGDLLNPEGGVDPQHLMFDDNLAPPARRKGSVASHTNHDDYDRLIHPSIRLFPDLPPPIAASDSEPSVIVEVMAIEQANADNAEVGISRSGNHQQAGWMSSSVKATFEGPNTISPIGTGYVFNSSGAGVDTCVSNTENGWSAVLNATPLKIGGGSKNVVHRKNSNTGFDLKSDFLMSSVQTESETIRGEHRPNVAKPVDVQTVSCATEMWREVLNNDEEYTMQSSKAGRYLPGDFFEGVQASMGNDATNKGIRKGSASKSASLLPIRGMEIVRPTKPQGESTRKTSVYRKSRSVERRKTEKEQPKVLAVEVVAGAESRSALDESTNPREPQAAARATTSSKERSLCVVQPCGGKVSASELSALASTQLMSKDTSLSEDCASRLRKKWGVTPKKAEKEDDEEERIRRAERFERINLALLKLEVCRKNNHSSHDTRGWASPTSDLDSRYETKPWTQAYSPSGATTDTLDNGYTSSIDPPRSKYWDREMAGGTSKRHNSRPRSLFPPPHSPVKTSADPPVDGLIYTPAKTASARSASWMFERSPDEDRYNSYFMDANSRLQELRVCDSMAAKNFARDLSSLASAVRGSELFSMIS
Protein: Cyclin-dependent kinase inhibitor domain-containing protein (Q22198)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAATTAGDGKRKAARCLFGKPDPEEVSRQLNSSLEEMYKKDSRKFNFDFSGGVPIVGSRGDYEFESISASEVPSFYREKIVRPRKIIARRNSTPVSDTVEMPSESPPVVESNETPLLIASTSTEVTVYEKPVTRSSAAKQSIEQQETYNLKQTKLTNYMPVRKRRSETCLVTAAVSMSRSVSIDSSMESCKEKRGSKIVHNNKGAPKRPLRFVASNVPKSAQSSTSDTVLVSSPRSPPAKKMTTSTRRSRRPIEAGDF
Protein: PslJ (Q9I1M9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- PslF
- PslI
- PslH
- PslE
- PslG
- PslL
- PslD
- PslA
- dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase
- Alginate biosynthesis protein AlgA
Sequence:
MSLGNLVAVVFGLAFGGALLMLSPAKAGAAMVGLAAAVTILRFPFWGLLLFALVATFMPYSTVNVGIRSTVSEAILALTWGAVLWHIFLSRLPPAPALRYRSTERMLLWLMLFTVLPFVVGQVSIKAEASGLSNWLRWLLNLSIVFLAGRLLVERKNRETLVIALLLGTLAMLLMSIAVFIRYRSASGMAPILAMFNYANLDTLKFGLEALSSRMGSPWMHPNATGGIMALLLPLAFCYGVANQGWRRGLGLAVAVLGAAAILLASSRGAMLSLAVVLFWMSLRKVPYTGRLLLLGVGLVVVLVLSYPPLQERLATIFSPQNASTEVRFDEYRMFPKAVARYPLGIGFKVDPPVPGTDLLGISNLWLNFMYKVGLGGMLLFIAVTWRWWREARPEKGPIRLTRDNAIWLGSTGGILAALVSGLFDHYFSFAVVMIGLFWLLVGINLLEARRLFPERQPQPRAVGYRKLKRQLERGAEA
Protein: UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (Q6FLP1)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- phosphoglucomutase
- phosphoglucomutase
- Alpha-1,4 glucan phosphorylase
- Glycogen [starch] synthase
- Glycogen [starch] synthase
- phosphopentomutase
- Trehalose-6-phosphate synthase
- Candida glabrata strain CBS138 chromosome G complete sequence
- glycogenin glucosyltransferase
- Glycogen debranching enzyme
Sequence:
MSTAKKHTKTHSTYAFESNTNSVAASQMRNALNKLADSIGSEHGDDARTRFENELDSFFTLFRRYLVEKSSSNTLEWDKIKSPNPEEVVRYDTINSQAENVSSLSKLAVLKLNGGLGTSMGCVGPKSVIEVREGNSFLDLSVRQIEHLNRQYDSDVPLLLMNSFNTDKDTEHLIKKYSANRIRIRSFNQSRFPRVYKDSMLPVPETYNDPKDAWYPPGHGDLFESLHASGELDALIAQGREILFVSNGDNLGATVDLKILNHMIETGAEYIMELTDKTRADVKGGTLISYDGQVRLLEVAQVPKEHIDEFKNIRKFTNFNTNNLWINLKAVKRLVESSALEMEIIPNQKTITRGGQEINVLQLETACGAAIRHFSGAHGVVVPRSRFLPVKTCSDLLLVKSDLFYLQHGALKLDPSRFGPNPLIKLGSHFKKVSDFSARIPHIPKLVELDHLTITGNVFLGKGVTLRGTVIIVCSDGQKIDIPNGSVLENVVITGNLQILEH
Protein: Target of rapamycin complex 2 subunit sin1 (TORC2 subunit sin1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (Q9P7Y9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases.
Interaction partners:
- Target of rapamycin complex 2 subunit ste20
- Serine/threonine-protein kinase tor1
- Target of rapamycin complex subunit wat1
- Serine/threonine-protein kinase tor2
- Target of rapamycin complex 2 subunit bit61
- Serine/threonine-protein kinase gad8
- Target of rapamycin complex 1 subunit mip1
- Target of rapamycin complex 1 subunit tco89
- Target of rapamycin complex 1 subunit toc1
- Mitogen-activated protein kinase sty1
Sequence:
MELTREKVLLLTFLRMQYSHILPDSIENRVISTEAPEWELDKSLQDLLIHDYDYSKTSFSSSPPIVANDTVSNVRKPSDTKQVNGAGGQVNHSRAEDSDYATSDLSESSDVGDDDNSCIFSFSKVPMQKDVASIKEEERLDPKISTLNNIDAIANLKLTNMVESSQAVNLTSSKQSSINQQSSVSTDYDDLRSISEESFHLSQGEIPLTFPMNSSLTDTEADAVVAVDALFPGKQRGTHNTVNKARSVSNAKAPTSALRALLEHKENSSQNGPLAENFATFSGHAESNALRLNIYFPSSESPSKPLFVELRKNVLVSEAIGYILLQYVNQQLVPPIEDEAQNPNYWNLRIVEDDGELDEDFPALDRVGPLSKFGFDAFALVKATPAQIKENQAAYPFKSKHPTSIPEANNKTHIRHTSSTSSQSQKQAQDVKDTLNTSHVVQVRLPPYGDNARFCNIEISKTTRLAMVLNQVCWMKQLERFKYTLRVAGSDTVLPLDKTFSSLDGNPTLELVKKKVRDKKGSTQQLPTSSPQNSVYGSIKKDAQSSTYNATDIMSSNTYQEFLVWKRQPVSFMGRHERLLAIDGEYVHIMPSESKNIFETPKTSSIHAGSIILCKQSKKSPCNFKMIVSKNRETKRYDFEVLSALEAAIIVSRIRALMNTVKKIN
Protein: Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) (Q9UUC6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62318}.
Interaction partners:
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein-associated protein B
- Small nuclear ribonucleoprotein Sm D1
- Pre-mRNA-splicing factor cwf2
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing factor prp1
Sequence:
MSLCIKLLHETQGHIVTMELENGSTYRGKLIEAEDNMNCQMRDISVTARDGRVSHLDQVYIRGSHIRFLIVPDMLRNAPMFKVGPGRSVPLPTRGRR
Protein: Tryptophan synthase beta chain (EC 4.2.1.20) (P0A879)
Organism: Escherichia coli (strain K12)
Function: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Interaction partners:
- Bifunctional protein TrpGD
- Tryptophan synthase alpha chain
- Anthranilate synthase component 1
- Tryptophan biosynthesis protein TrpCF
- Aminodeoxychorismate synthase component 1
- L-threonine dehydratase catabolic TdcB
- Serine hydroxymethyltransferase
- L-threonine dehydratase biosynthetic IlvA
- Tryptophanase
- Phosphoserine phosphatase
Sequence:
MTTLLNPYFGEFGGMYVPQILMPALRQLEEAFVSAQKDPEFQAQFNDLLKNYAGRPTALTKCQNITAGTNTTLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILEREGRLPDAVIACVGGGSNAIGMFADFINETNVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTEDGQIEESYSISAGLDFPSVGPQHAYLNSTGRADYVSITDDEALEAFKTLCLHEGIIPALESSHALAHALKMMRENPDKEQLLVVNLSGRGDKDIFTVHDILKARGEI
Protein: Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (E9PIM9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC
Protein: Protein LEO1 homolog (Protein VERNALIZATION INDEPENDENCE 4) (Q9FNQ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3). Involved in regulation of flowering time. Required for the expression of the flowering repressor and MADS box gene FLC. Involved in the control of seed dormancy and germination.
Subcellular location: Nucleus {ECO:0000269|PubMed:20363855}.
Interaction partners:
- FACT complex subunit SSRP1
- Protein PAF1 homolog
- Protein RTF1 homolog
- Protein CDC73 homolog
- Protein CTR9 homolog
- FACT complex subunit SPT16
- WD repeat-containing protein VIP3
- FACT complex subunit
- Transcription elongation factor SPT4 homolog 2
- Transcription elongation factor SPT6 homolog
Sequence:
MVKGEKRSEMMLNLFGDNSEEEEIESEHECNRRQPNYASDEAEGGVEPEGEGEAEVEVHGEAEAESDGEQGDVELDPGESEGEREQSSQEADPQEESEARDSDSDNKEEEHGGRVAKKRRQEVVESGSERSGEKHYESEDEEVDQTRSPRSPSEEKEEVQVAQSDVNIRNVFGSSDDEDAEEYVRNDVEQDEHRSPIEDEEGSEKDLRPDDMVLDDIIPEEDPQYESEAEHVEARYRERPVGPPLEVEVPFRPPPGDPVKMNMIKVSNIMGIDPKPFDAKTFVEEDTFMTDEPGAKNRIRLDNNIVRHRFVKSRDGKTYSESNARFVRWSDGSLQLLIGNEVLNITEQDAKEDQNHLFIKHEKGILQSQGRILKKMRFTPSSLTSNSHRLLTAIVESRQKKAFKVKNCVTDIDPEREKEKREKAESQNLKASTKLSQAREKIKRKYPLPVERRQLSTGYLEDALDEDDEDYRSNRGYEEDLEAEAQRERRILNAKKSHKGIPGRSSMTSARPSRRQMEYSESEREESEYETEEEEEEKSPARGRGKDSEDEYEEDAEEDEEERGKSNRYSDEDEEEEEVAGGRAEKDHRGSGRKRKGIESDEEESPPRKAPTHRRKAVIDDSDED
Protein: Odorant receptor 10a (Q9VYZ1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to esters, and specifically to ethyl hexanoate, benzaldehyde, and acetophenone.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Odorant receptor 42b
- Odorant receptor 85a
- Odorant receptor 22a
- Gustatory receptor 10a
- Odorant receptor 67a
- Odorant receptor 43a
Sequence:
MSEWLRFLKRDQQLDVYFFAVPRLSLDIMGYWPGKTGDTWPWRSLIHFAILAIGVATELHAGMCFLDRQQITLALETLCPAGTSAVTLLKMFLMLRFRQDLSIMWNRLRGLLFDPNWERPEQRDIRLKHSAMAARINFWPLSAGFFTCTTYNLKPILIAMILYLQNRYEDFVWFTPFNMTMPKVLLNYPFFPLTYIFIAYTGYVTIFMFGGCDGFYFEFCAHLSALFEVLQAEIESMFRPYTDHLELSPVQLYILEQKMRSVIIRHNAIIDLTRFFRDRYTIITLAHFVSAAMVIGFSMVNLLTLGNNGLGAMLYVAYTVAALSQLLVYCYGGTLVAESSTGLCRAMFSCPWQLFKPKQRRLVQLLILRSQRPVSMAVPFFSPSLATFAAILQTSGSIIALVKSFQ
Protein: Mitochondrial uncoupling protein 1 (AtPUMP1) (O81845)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: PUMPS are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. This leads to a decrease in the efficiency of oxidative phosphorylation and an increase in heat production. Is involved in protecting plant cells against oxidative stress damage and maintaining the redox balance of the mitochondrial electron transport chain to facilitate photosynthetic metabolism. May play a regulatory role during photorespiration.
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Ubiquinol oxidase 1a, mitochondrial
- External alternative NAD
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Ubiquinol oxidase 1c, mitochondrial
- Internal alternative NAD
- At2g18890
- Cytochrome b-c1 complex subunit 8-1, mitochondrial
- Ubiquinol oxidase 1b, mitochondrial
Sequence:
MVAAGKSDLSLPKTFACSAFAACVGEVCTIPLDTAKVRLQLQKSALAGDVTLPKYRGLLGTVGTIAREEGLRSLWKGVVPGLHRQCLFGGLRIGMYEPVKNLYVGKDFVGDVPLSKKILAGLTTGALGIMVANPTDLVKVRLQAEGKLAAGAPRRYSGALNAYSTIVRQEGVRALWTGLGPNVARNAIINAAELASYDQVKETILKIPGFTDNVVTHILSGLGAGFFAVCIGSPVDVVKSRMMGDSGAYKGTIDCFVKTLKSDGPMAFYKGFIPNFGRLGSWNVIMFLTLEQAKKYVRELDASKRN
Protein: Large ribosomal subunit protein eL8B (60S ribosomal protein L8-B) (L4) (L4-1) (RP6) (YL5) (P29453)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein uL6B
- Large ribosomal subunit protein eL14B
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS12
- Large ribosomal subunit protein eL36B
- Large ribosomal subunit protein eL13B
Sequence:
MAPGKKVAPAPFGAKSTKSNKAKNPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRLQRQKKILSIRLKVPPTIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAIAEGKSKQDASPKPYAVKYGLNHVVSLIENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIIKGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFADKYDEVKKHWGGGILGNKAQAKMDKRAKTSDSA
Protein: Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (P43593)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Predominant proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Has proteasome-inhibitory activity and delays the degradation of ubiquitinated proteins to provide a time window allowing gradual deubiquitination of the substrate. Stabilizes the association of HUL5 with proteasomes and works in opposition to polyubiquitin elongation activity of HUL5.
Interaction partners:
- Polyubiquitin
- 26S proteasome regulatory subunit RPN13
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit RPN9
- 26S proteasome regulatory subunit RPN7
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit RPN2
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit 6A
Sequence:
MSGETFEFNIRHSGKVYPITLSTDATSADLKSKAEELTQVPSARQKYMVKGGLSGEESIKIYPLIKPGSTVMLLGTPDANLISKPAKKNNFIEDLAPEQQVQQFAQLPVGFKNMGNTCYLNATLQALYRVNDLRDMILNYNPSQGVSNSGAQDEEIHKQIVIEMKRCFENLQNKSFKSVLPIVLLNTLRKCYPQFAERDSQGGFYKQQDAEELFTQLFHSMSIVFGDKFSEDFRIQFKTTIKDTANDNDITVKENESDSKLQCHISGTTNFMRNGLLEGLNEKIEKRSDLTGANSIYSVEKKISRLPKFLTVQYVRFFWKRSTNKKSKILRKVVFPFQLDVADMLTPEYAAEKVKVRDELRKVEKEKNEKEREIKRRKFDPSSSENVMTPREQYETQVALNESEKDQWLEEYKKHFPPNLEKGENPSCVYNLIGVITHQGANSESGHYQAFIRDELDENKWYKFNDDKVSVVEKEKIESLAGGGESDSALILMYKGFGL
Protein: Bifunctional helicase and thymine dioxygenase JBP2 (J-binding protein 2) (LtJBP2) [Includes: Probable DNA helicase JBP2 (EC 3.6.4.12); Thymine dioxygenase JBP2 (EC 1.14.11.6)] (B6EU02)
Organism: Leishmania tarentolae (Sauroleishmania tarentolae)
Function: Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, however it binds chromatin.
Subcellular location: Nucleus {ECO:0000269|PubMed:19114062}.
Interaction partners:
Sequence:
MLNGLTRVSTSSELESILDIVQSSGEIAVVFISPSIGDLETITSETQRRQLRIAGIPRGGYTILPAIPLYDDELLQMCERYTAANDYEKAQIRDSLFMREYPLFAYSVRNHKALFHPADYVSRILQFCSYYVQAPDADVLSLLDRSPFLHISPIKEICTHIRLIARGTPLAPEDSESPAPEQLRFHAESDAEKLAAERAGAMSIATSSGGASETEQLSLFSGVVPSALFQKDAVEEVDKDTEETMVDLTGEETVDAVHSFQAEYLTLDGLELVTKAAIFYDREGEGQRIVAVYIPGGVPEDTCRAAAAVLEPAATKKNLRALTNGGLPPDTGLVGYYDYLTNPTRHKCRETEFSRRNWGLLAQSEPLLKHLDKLYSQLAPMHHHLQKVAIPSQYQLCGTVFSTITVNRNFRTAVHTDKGDFRSGLGVLSVINGEFEGCHLAIKKLKKAFQLKVGDVLLFDTSLEHGNTEVINPEIHWQRTSIVCYLRTGLMSSVCEMERRKHLNRLILQQLRNTEVLNTTVNINGADSSLPPLFVPTRLASHLAPVQLAALGFIVERTEKQSGCVVAMTMGLGKTLVALTLCFSQLHLAPQADILILTPKPIISHWVDEKNKWAMHGLHFPHFVASDGLNSLEFEQQLLEYERQKNNEKPKLGHVFVINGEYLAGFLRRFKRFTPLLIIVDEGHRVAAKGNKLTESLDRLRCNLRIVLSGTPLQNDASELYRLVGWVNKGVGRVLPPKRFQELANDINQFVEGDDGAFYNAVMAQEYIQDWMRGFVFREMENDLPPLHDYLLICGSSDVQREYEEKLGLTETTMTALKATEHRPHHLSTHPACYLAFISDSYQSMVSGWTVRAQANTSRMRVSQLEEIDTMRLEHYVQMVENEQLDTFIDLSGKMRVLVDIVLRVQARKEKLIIFSLYVGSQDLIHRTLTALRVCTFTVRGRDSQDRRRRAMQEFSENKDLIVLVLSTKIAAYGLDFTAANHVVLFDSWWNPQVDAQAIARAYRRNQRKPVTVYRLISATENKFVLSSQTRKIALFKCILHERTSRQALPDELEDCAANEKDEERRSFWAKLKTTLLAGGTRALLNVYRYQESVRESE
Protein: Packaging protein UL32 (Q77CD0)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Subcellular location: Host cytoplasm {ECO:0000256|RuleBase:RU364029}. Host nucleus {ECO:0000256|RuleBase:RU364029}.
Interaction partners:
Sequence:
MSSRSRMFARADDGAGGGDGARSWAEGAFRAPYVAFDPALLKENGQLLEELVFAAHLMEVPSPRDDGDEDGGGDRDGAAAEGGGSADVVPFVEEAAAALAIDRPCAVCRTIDAYRREFGLAPPWVADYAMLCAKSLAAPPCAVAIVVAAFEFVYLMDRHFLAAHRATLVGAFATRVLTLVDVHKHFFLHVCFRTDGGVPGNNAGNAAGGARRAAEKVRYSNYSFLIQSATRALLARRRRRPEAPAVPADGAGPRALRPQSLATALLSWKECARLVDCSAPLPGGGGGARAARRPGGTCCDAARARAAEYEARAAVLPSPRGGDADEASAASAADGAPADRWAYADLALLLLAGVATRGDGAVAERAIASRRAAVDRYWAARAGFLAANTAPRFARFAAGDARPSVALGPVLATALKHITGRGRTTGECVLCNLLLTPAHWRALRALRADVVAHSANNAGLFDCILPVLDARAGAPVEGDGGRFFAALALLEPEAVYKHLFCDPMCAACELQADPEVLFAFSDGDARDADELDLYKARVASENSFEGRVCAGLWALAYAFKTYQRFPPKPTACAAFVRDAGQLLRRHGVALVSLEHTLCHYV
Protein: Complement component C9 (F1SMJ6)
Organism: Sus scrofa (Pig)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}. Target cell membrane {ECO:0000256|ARBA:ARBA00004276}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004276}.
Interaction partners:
- Complement C5a anaphylatoxin
- Complement component C6
- Complement C8 alpha chain
- Complement component C7
- Complement C8 gamma chain
- CD59 glycoprotein
- Vitronectin
- Complement component C8 beta chain
- Complement C3
- Complement C3
Sequence:
MRVRRRFTFAVCILEISILSAGPTPSYHPKPVDCNGTPSPIDCRMSPWGEWSRCDPCLKQMFRSRSIETFGQFNGQKCVDAVGDRRQCVPTEPCEDLEEDCGSDFQCGTGRCIKRRLLCNGDNDCGDFSDEDDCDSDPRPPCRERVVEESELARTAGYGINILGMDPLTTPFDNEYYNGLCDRVRDGNTLTYYRKPWNVAALIYETKVDKNFRTEYHERQIQVLKTIIEEKKSNFNADLTIKFTPTEAIEQLKSKNVELANEENSNPMNNKAHFRFTYSKTETYKLLLSYSSKKEKIFLHVKGVIHLGRFVMRKRDVMLTKTFLDDVKYLPSTYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKATMTEKGIELRDVHRCLGFNLDLSLNFGVEIKGKIDSENCLKRGDGKTENIMNDDFIDDVISFIRGGTRKYATELKEKLLKGAKMINVTDFVNWASSLNDAPVLINQKLSPIYDLIPVKLNDAHLKRQNLERAIEDYINEFNVKMPTVPEWRDSDSAGWTVFVFLPKQISGNCL
Protein: Shugoshin 1 (Zgc:158297) (A1L1S4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome, centromere {ECO:0000256|ARBA:ARBA00004584}.
Interaction partners:
Sequence:
MVQKKSFQQSLEDIKEKMKEKRNRRLSAAASARRSVQLRGAAVVKPLVLKSVQANNKALAVALQAEREKVRQAQGVILQLKKERQTLLFHLLMLKRTLRERPAHITPQEVSPPEETSPPRPAQPVSPRPVDVCDDVQQLPSAEARLSADTRSVSLPPTVGMRRKRCSGMKRRRSSRFYSNPEQMEESAAQPRVEDLHQHQQAEEARVQPVEPDVQLCTAEAPARKKRSAQPKAERGRKADRAPLKKPWENHRPRARSKSRERPQSRAGATLTPVDRLNSSLGGNDTFDFDCEEAVHLTPFRDKHKHTETKPEPEPHAAAADGMENSSPMEEQDEEKEEEEETPYIPNRRIRRACSPAARRARSKRRSNNMQTHSTGKTSSPMEVEEEEEEQEEEEETPYIPNRRIRRACSPAARRARSKRRSNNKQTHSTGSCSAAAVMEEQDTADLLFTSPVCDAEERRRASDLQSGPPQLSSSPAESLVSMMSPAEPELLLLQSPVFEFQQNQENQQPQPARRRTGGLVLRSFLGLALSDVSNVVCPAARQTSSSAGHTPQSCRRQRRAASAVNYKEPSINTKLRRGDKFTDTRFLRSPIFKQKSSSRRSSFKKMEIYNEAFVGCR
Protein: starch synthase (EC 2.4.1.21) (F4IAG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEVCWQIQRPASLRPGFQEKGRVKINTFSVGFFPRSISSIASLESQYKSNGFLHQITASADFSRKKQGRMAASGPKSSGPRGFGRRTTVGSAQKRTQKKNGEKDSNATSTATNEVSGISKLPAAKVDVQKQSSVVLNERNVLDRSDIEDGSDRLDKKTTDDDDLLEQKLKLERENLRRKEIETLAAENLARGDRMFVYPVIVKPDEDIEVFLNRNLSTLNNEPDVLIMGAFNEWRWKSFTRRLEKTWIHEDWLSCLLHIPKEAYKMDFVFFNGQSVYDNNDSKDFCVEIKGGMDKVDFENFLLEEKLREQEKLAKEEAERERQKEEKRRIEAQKAAIEADRAQAKAETQKRRELLQPAIKKAVVSAENVWYIEPSDFKAEDTVKLYYNKRSGPLTNSKELWLHGGFNNWVDGLSIVVKLVNAELKDVDPKSGNWWFAEVVVPGGALVIDWVFADGPPKGAFLYDNNGYQDFHALVPQKLPEELYWLEEENMIFRKLQEDRRLKEEVMRAKMEKTARLKAETKERTLKKFLLSQKDVVYTEPLEIQAGNPVTVLYNPANTVLNGKPEVWFRGSFNRWTHRLGPLPPQKMEATDDESSHVKTTAKVPLDAYMMDFVFSEKEDGGIFDNKNGLDYHLPVVGGISKEPPLHIVHIAVEMAPIAKVGGLGDVVTSLSRAVQELNHNVDIVFPKYDCIKHNFVKDLQFNRSYHWGGTEIKVWHGKVEGLSVYFLDPQNGLFQRGCVYGCADDAGRFGFFCHAALEFLLQGGFHPDILHCHDWSSAPVSWLFKDHYTQYGLIKTRIVFTIHNLEFGANAIGKAMTFADKATTVSPTYAKEVAGNSVISAHLYKFHGIINGIDPDIWDPYNDNFIPVPYTSENVVEGKRAAKEELQNRLGLKSADFPVVGIITRLTHQKGIHLIKHAIWRTLERNGQVVLLGSAPDPRIQNDFVNLANQLHSSHGDRARLVLTYDEPLSHLIYAGADFILVPSIFEPCGLTQLIAMRYGAVPVVRKTGGLFDTVFDVDHDKERAQAQVLEPNGFSFDGADAPGVDYALNRAISAWYDGREWFNSLCKTVMEQDWSWNRPALEYLELYHSARK
Protein: Cytoplasmic polyadenylation element binding protein 1 (A4PES2)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MASPLEEEAGKIKDCWDNQEAPALSTCSNANIFRRINTILDNSLDFSRVCTTPINRGIHDHLPDFQDSEETVTSRMLFPTSAQDSSRGLPDANDLCLGLQSLSLIGWDRPWSTQDSDSSAQSGTHSVLSMLHNPLGNVLGKPPLSFLPLDPLGSDLVDKFPAPSVRRSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSLTGGGPRDPLKMGVGSRMDQEQAALAAVTPSPTSASKRWPGASVWPSWDLLEAPKDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGNTPKGYVYLVFELEKSVRALLQACSRDSLNPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVRSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVSAAFVEIKTTKFTKKVQIDPYLEDSLCHICSSQPGPFFCRDQVCFKYFCRSCWHWRHSVEGLRHHSPLMRNQKNRDAS