wanglab/gogpt-training-data huggingface dataset:
Protein: Glycine receptor subunit alpha-3 (O75311)
Organism: Homo sapiens (Human)
Function: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P24524}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:P24524}. Cell projection, dendrite {ECO:0000250|UniProtKB:P24524}. Synapse {ECO:0000250|UniProtKB:P24524}. Cell membrane {ECO:0000269|PubMed:26416729, ECO:0000269|PubMed:9677400}; Multi-pass membrane protein {ECO:0000269|PubMed:26416729}. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. {ECO:0000250|UniProtKB:P24524}.
Interaction partners:
- Glycine receptor subunit beta
- Glycine--tRNA ligase
Sequence:
MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
Protein: Hydroxyacylglutathione hydrolase GloC (EC 3.1.2.6) (Accessory type II glyoxalase) (Glyoxalase II 2) (GlxII-2) (P75849)
Organism: Escherichia coli (strain K12)
Function: Type II glyoxalase, isozyme of GloB, that hydrolyzes (R)-S-lactoylglutathione to (R)-lactate and glutathione. Plays a minor contribution to methylglyoxal (MG) detoxification in E.coli, compared to GloB. The two isoenzymes have additive effects and ensure maximal MG degradation.
Interaction partners:
- Lactoylglutathione lyase
- Peptidoglycan L,D-endopeptidase MepK
- Hydroxyacylglutathione hydrolase GloB
- D-lactate dehydrogenase
- Protein/nucleic acid deglycase 1
- Quinone-dependent D-lactate dehydrogenase
- 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD
Sequence:
MNYRIIPVTAFSQNCSLIWCEQTRLAALVDPGGDAEKIKQEVDDSGLTLMQILLTHGHLDHVGAAAELAQHYGVPVFGPEKEDEFWLQGLPAQSRMFGLEECQPLTPDRWLNEGDTISIGNVTLQVLHCPGHTPGHVVFFDDRAKLLISGDVIFKGGVGRSDFPRGDHNQLISSIKDKLLPLGDDVIFIPGHGPLSTLGYERLHNPFLQDEMPVW
Protein: Ubiquinol-cytochrome c reductase core protein 2 (H3BP04)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKLLTRAGSFSFTKLPNGLVIASLENYSPVSRIGLFIKAGSRYEDFSNLGTTHLLRLTSSLTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQPQLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEE
Protein: Replication factor C, subunit 3, putative (Q38DH5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Proliferating cell nuclear antigen
- Replication factor C, subunit 2, putative
- Replication factor C, subunit 4, putative
- Replication factor C, subunit 5, putative
- Chromosome transmission fidelity protein 18 homolog
- Checkpoint protein HUS1
- Replication factor C, subunit 1, putative
- DNA polymerase eta
- BRCT domain-containing protein
- AAA+ ATPase domain-containing protein
Sequence:
MTGEGTLSNGQPAKNSTLPWVEKYRPTTLDDVVAHEEILDTTRRLMNSGSMPHLLFYGPPGTGKTTTIKACAHHLFGKERLRANVLEMNASDDRGIDVVRQQVREFASTSSIFFQNNPGNQTVTNFKLVILDEADQMSSDAQAALRRIIEKFTKNVRFCILCNHINKIIPALQSRCTRFRFSPVKKSAMLPRLKLIAREEGVPFTDEGLISAFRLSDGDMRRCLNTMQASSMSAGEITEESVYRTTGNPTPTDVRVMVGDMLSHNYATSWEKVQQLVVDKGVSTADLVREVHLIVMAMDLPQDCKCFLLIKLADVEYYAAGGTREMINIGGVLGAFQLVKEALTQNKPIFELAGGLC
Protein: proton-translocating NAD(P)(+) transhydrogenase (EC 7.1.1.1) (A0A8I6A0P0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRSELPCLLLVSRPWSSRVLTLLWNQEQAKLPNSQMISTEQQGPRSKERRKFWLLIWWSKAPMVNPTLGAHEADFLKPSGTLISFIYPAQNPDLLNKLSERKTTVLAMDQVPRVTIAQGYDALSSMANISGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAVVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFSKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYVHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFHFEVKDDFDFGTMSHVIRGTVVMKDGNVIFPAPTPKNIPKEAPAKQKTVAELEAEKAGTVSMYTKTLRTASVYSAGLTGMLGLGIVAPNLAFSQMVTTFGLAGIIGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLALMGGHFYPSTTSQSLAALATFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLLPGGTFVGGYLAALYGGYNIEEIMYLGSGLCCVGALGGLSTQGTARLGNALGMIGVAGGLAATLGGLKPDPQLLAQMSGAMAMGGTIGLAIAKRIQISDLPQLVAAFHSLVGLAAVLTCMAEYIVEYPHFAMDATSNFTKIVAYIGTYIGGVTFSGSLVAYGKLQGILKSAPLLLPGRHALNAGLLAASVGGIIPFMADPSFTTGIMCLGSVSALSTLMGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAVEMIREANSIVITPGYGLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINSDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK
Protein: Deacetylase sirtuin-type domain-containing protein (D3YT50)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHITQETDISDAPETNTDSSRQRTESTTSVSSESWQNNDEMMSNLRRAQRLLDDGATPLQIIQQIFPDFNASRIATMSENAHFAILSDLLERAPVRQKLTNYNSLADAVELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIKRVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRESLPHYNADIELLGNCDDIIRDICFSLGGSFTELITSYDSIMEQQGKTKSQKPSQNKRQLISQEDFLNICMKEKRNDDSSDEPTLKKPRMSVADDSMDSEKNNFQEIQKHKSEDDDDTRNSDDILKKIKHPRLLSITEMLHDNKCVAISAHQTVFPGAECSFDLETLKLVRDVHHETHCESSCGSSCSSNADSEANQLSRAQSLDDFVLSDEDRKNTIHLDLQRADSCDGDFQYELSETIDPETFSHLCEEMRI
Protein: MX dynamin like GTPase 1 (F8W8T1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQFPG
Protein: Orexin/Hypocretin receptor type 1 (Hypocretin receptor type 1) (Orexin receptor type 1) (Ox-1-R) (Ox1-R) (Ox1R) (P56718)
Organism: Rattus norvegicus (Rat)
Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O43613}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O43613}.
Interaction partners:
- Hypocretin neuropeptide precursor
- Orexin receptor type 2
- Oxidation resistance protein 1
- Corticotropin-releasing factor receptor 1
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
Protein: Polyamine-modulated factor 1 (PMF-1) (Q6P1K2)
Organism: Homo sapiens (Human)
Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.
Subcellular location: Nucleus {ECO:0000269|PubMed:16585270}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16585270}. Note=Associated with the kinetochore.
Interaction partners:
- Kinetochore-associated protein DSN1 homolog
- Kinetochore-associated protein NSL1 homolog
- Protein MIS12 homolog
- Outer kinetochore KNL1 complex subunit ZWINT
- Outer kinetochore KNL1 complex subunit KNL1
- Centromere protein C
- Kinetochore protein Spc24
- Kinetochore protein Nuf2
- Nuclear factor erythroid 2-related factor 2
- Diamine acetyltransferase 1
Sequence:
MAEASSANLGSGCEEKRHEGSSSESVPPGTTISRVKLLDTMVDTFLQKLVAAGSYQRFTDCYKCFYQLQPAMTQQIYDKFIAQLQTSIREEISDIKEEGNLEAVLNALDKIVEEGKVRKEPAWRPSGIPEKDLHSVMAPYFLQQRDTLRRHVQKQEAENQQLADAVLAGRRQVEELQLQVQAQQQAWQALHREQRELVAVLREPE
Protein: Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein) (P35123)
Organism: Mus musculus (Mouse)
Function: Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. Deubiquitinates HAS2. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15494318}. Nucleus {ECO:0000269|PubMed:15494318}. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. {ECO:0000269|PubMed:15494318}.
Interaction partners:
- Spliceosome associated factor 3, U4/U6 recycling protein
- DNA endonuclease RBBP8
- TNF receptor-associated factor 6
- E3 ubiquitin-protein ligase TRIM21
- Ubiquitin carboxyl-terminal hydrolase 14
- Polyubiquitin-C
- TNF receptor-associated factor 2
- Ubiquitin carboxyl-terminal hydrolase 15
- Zinc finger-containing ubiquitin peptidase 1
- TOX high mobility group box family member 4
Sequence:
MAEGRGSRERPDVETQKTELGALMGTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPAEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTIQDAGLYQGQVLVIEPQNEDGTWPRQSLQSKSSTAPSRNFTTSSKPSASPYCSVSASLIANGDSTNSSGMHSSGVSRGGSGFSASYNCQEPPSPHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTEYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDTHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFILDGLHEDLNRVKKKPYLEPKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRIMEVFLVPADPQCRPIQYRVTVPLMGAISDLCEALSKLSGIAAENMVVTDVYNHRFHKIFQMDEGLSHITPRDDIFVYEVCNTSMDGSECITLPVYFREKKSRPSSASSGAVLYGQPLLVSVPKHKLTLESLYQAVCDRISRYIKQPLPDEFLSSPLEPGACNGSRSSYEGDEEEEMDHQEEGKEQLSEVEGSGEDDQGDDHSESAQKVKGQPRHKRLFTFSLVNSCGTADINSLATDGKLLKLNSRSTLAIDWDSETRSLYFDEQESEACEKHLSMSQPQKKKKAAVALRECIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPVRALNMSEFVCDRSARPYVYDLIAVSNHYGAMGVGHYTAYAKNRLNGKWYYFDDSSVSLASEDQIVTKAAYVLFYQRRDDECSSTSSLGSFPGSDGGVKLSSSHQGMGDEEAYNMDTN
Protein: Chitinase (EC 3.2.1.14) (EfChi18A) (Q838S2)
Organism: Enterococcus faecalis (strain ATCC 700802 / V583)
Function: Involved in chitin degradation. Catalyzes the cleavage of glycosidic linkages in chitooligosaccharides and in alpha- and beta-chitin. Its activity on chitooligosaccharides increases considerably with degrees of polymerization (the initial rate of hydrolysis for GlcNAc5 is about 130-fold higher than that for GlcNAc3). Its activity is greatly stimulated in the presence of the lytic chitin monooxygenase EfCBM33A, which attacks the crystalline structure of chitin and makes the polymer more accessible to the chitinase; combining the two enzymes leads to rapid and complete depolymerization of crystalline chitin, especially with beta-chitin as a substrate. Is likely involved in a chitin degradation pathway that allows E.faecalis V583 to grow on chitin as a carbon source.
Subcellular location: Secreted {ECO:0000305|PubMed:22210154}.
Interaction partners:
- Lytic chitin monooxygenase
Sequence:
MKLKKIIPAFPLLSTVAVGLWLTPTQASADAADTMVDISGKKVLVGYWHNWASKGRDGYKQGTSASLNLSEVNQAYNVVPVSFMKSDGTTRIPTFKPYNQTDTAFRQEVAQLNSQGRAVLLALGGADAHIQLVKGDEQAFANEIIRQVETYGFDGLDIDLEQLAITAGDNQTVIPATLKIVKDHYRAQGKNFIITMAPEFPYLKPGAAYETYITSLNGYYDYIAPQLYNQGGDGVWVDEIMTWVAQSNDALKYEFLYYMSDSLIHGTRGYLQIPNDKLVLGLPANRDAAGSGYVVEATPVAKTFDQLAKDGNPIRGLMTWSANWDVGQDVNGKSYNNEFATRYSNLVK
Protein: Probable pectin methylesterase CGR2 (EC 2.1.1.-) (Cotton Golgi-related 2) (Q9M2Y6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with CGR3, required for homogalacturonan pectins (HG) methylesterification in the Golgi apparatus prior to integration into cell walls, essential for general growth and development. Promotes rosette growth. Impacts carbon (C) partitioning, photosynthesis and respiration efficiency by influencing leaf mesophyll cell walls morphology and physiology; pectin methylesterification modulates both expansion and positioning of cells in leaves, probably by changing cell walls plasticity.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:25704846}; Single-pass membrane protein {ECO:0000269|PubMed:25704846}.
Interaction partners:
- Probable pectin methyltransferase QUA2
- Probable pectin methyltransferase QUA3
- Protein ROOT HAIR DEFECTIVE 3 homolog 2
- Galacturonosyltransferase 8
- Ergosterol biosynthetic protein 28
- Protein trichome birefringence-like 10
- Protein FRIABLE 1
- Galactan beta-1,4-galactosyltransferase GALS2
- Galactan beta-1,4-galactosyltransferase GALS3
Sequence:
MARRQVGSTRRVGDGGSFPFAGALHSKSRSSPLLSICLVLVGACLLIGYAYSGPGIFKSIKEVSKVTGDYSCTAEVQRAIPVLKKAYGDGMRKVLHVGPDTCSVVSSLLKEEETEAWGVEPYDIEDADSHCKSFVSKGLVRVADIKFPLPYRAKSFSLVIVSDALDYLSPKYLNKTVPELARVASDGVVLFAGLPGQQRAKVAELSKFGRPAKMRSASWWNRFFVQTNLEENDAPSKKFEQAVSKGLYKPACQVFHLKPLH
Protein: Ras-like GTpase (A0A0P0ZF19)
Organism: Plasmodium falciparum (malaria parasite P. falciparum)
Interaction partners:
Sequence:
MKNVLKKEFVRSFCYKICIAGACNSGKSSFNNDLLDRLNVSHKKSVISNVDNYCINNNENIFKLHKKKCSVTDTIGLNERMISKLEKWKLEGYNMDMENNNILKNYYNLIMDSNLIFLCIKHTEIRQCDILSYNIIKDMYKNLDNIYTIVYNNIKDGTNTQHTHIQSYNFLDIYEDFTNIIFYPYDINEDLTNVIKEKIINFYEIKKVTSQQNDDQFKDHHELKNDISQDNDNILKNCHINKNLLNTLNKKEEEKEEELLFNNNQMYDIIDESVRIFHPSMSSETRNYFYKFVNLKKKDKSNMKLFNDYFSERILNRTPRKIGQVEFDEKKNKIINNENNENVKNNENVKNNGNSDNNGNSDNNGNSDNNGNSDNSDNNGNSDNNDNSDNNDNNVITMNNVKNTEETGKDNKTKENVMNTNLYPMDTQTVDNTMYQYNDNYDKFIKKKQTSIYETPKNKEEDDNDDTNKFREYFFRKIQNNYNFEERKKDIQALKNKRIRILKNILNKKEHANPYDLININKKKYDDKDIQENHTNDVPLFYCTTNDIINEGNKHIDIVNKKDVKDKDLEQINHRKVDENMHRDINIEMDSTALHNCVDDDDNNNNNNNNKININSYRNKIMMNDENMCNNKDIKVCVLGEKNCGKTSLIESILKNNIINENDIYELFGKRKYINNDMSFYYKNKKIEILDTCRLSKQHKFKNEDLLFDENNRVYTNIRKSDICIYIKEIKNNNINLNKVDKKMIFYLLKEKKNIIFIVNKIDLILTNFEKKRNDFLQEFSNLFNDIPIIFLNTKNNTHINTLLNKIIHIHKMNNVIISTSLLNLFLMQFLKLFPIPWLKKKKCHFKYIKQINTNPITFLIFTNLYRKVPNNYLTFFKKKLKHEFDLRYINIQFIFKTTCDNKEKVKGRIK
Protein: Transcription factor Sox-5 (xSox-5) (SRY (sex determining region Y)-box 5) (P40647)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: sox5 and sox6 cooperatively bind with sox9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate sox9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P35710}.
Interaction partners:
Sequence:
MLTEPELPPDINRMSSKRPASPYGEADGEVAMATSRQKMEDEGSDGLPAFHLPLHVGFPSKPHSEEFQAVSLLTQESCDRRSPSYQLNSMELDCNKMSAFALHNVATSPMKAEEVGRQSGDSLSNSMLGTPERRKGSLADVVDTLKQRKMEELIKSEPEETPTIEKLLSKDWKDKLLAMGSGNLADVKGTPESLAEKERQLMTMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAAAQQGFLIPPGFSYKPGCSDPYPLQLIPTTMAAAAAATPGLAPLQLQQLYAAQLAAMQVSPGAKLPGVPQNNLSNSISPSSVHTDKSTSSPPPKSKDDVAQPLNLSAKPKGSDSRSSSSPTSPHIQRLSSGSTHKPISSTSASTPIRLNSIDILSSLTSPGYLNDHDAVTKAIHEARQMKEQLRREQQALDGKVVNSLGLNNCRTEKDKSSLDALTQQLTGKPNEDKFSHAMMDFNLSGDSDGSAGISESRIYREARGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRSRRQGQQTQIPISTAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGIKQEELHIKEEIRGDNINGEMYDEYDEEDDPDIDYGSDSENPSATQAN
Protein: F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57) (Q9UK97)
Organism: Homo sapiens (Human)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23263282}.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
- S-phase kinase-associated protein 1
Sequence:
MPDIIWVFPPQAEAEEDCHSDTVRADDDEENESPAETDLQAQLQMFRAQWMFELAPGVSSSNLENRPCRAARGSLQKTSADTKGKQEQAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKPLDYKYRYFRRVPVQEADQSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKSTGETAVSAFEIDKMYTPLFFARVRSYTAFSERPL
Protein: Syntabulin (A0A8I6A508)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
LRPYLPVQSLRPPAPVPTCSEAPGAAALAPEAKRPRGPERAGGCRTTCANPAGAGGAGRGWLLQPQRKPVATRRVAGRRPSPTQASRAFRHTVWTAQWTRSAKETVPPPGRRRRRGEPAGNDEMGPLRESKKEQRVQHQEKEFSRSRIPRLILRPHLPQQQQQQQNKVSPASESPFSEEESREFNPSSSGRSARTISSNSFCSDDTGCPSSQSVSPVKTPSDTGHSPIGFCPGSDEDFTRKKCRIGMVGEGNIQSARYKKESKGGIIKPGSEADFSSSSSTGSISAPEVHMSTTGNKRASFSRNRGPHGRSNGAPSHKSGSSPPSPREKDLVSMLCRNPLSPSNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLRTKLKESERRLHERESEIMELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHNSSLRDELCLDFSFDSPEKSLPLSSTYDKMADGLSLEEQITEEGADSELLVGDSMAEGTDLLDEIVTATTTESGDLEFVHSTPGPQALKPLPLVSQEEGIVVVEQAVQTDVVPFSPAISELLQSVLKLQDSCPTSSASPDESGADSMESFSESISALMVDLTPRSPNSAILLSPVEIPFSKAATEARANRLMRELDFAACTEERLDSILSLSQGGVVRQYWSSSFLVDLLAVAAPVVPTVLWVFSTQRGGTDPVYNIGALLRGCCVVALHSLRRTAFHMKT
Protein: Tight junction protein 1 (G3V1L9)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
Interaction partners:
Sequence:
MRRLEGLCLRRRRRRRGPARERSGDKMKYQKYLTVLQMAIGVTPSNRGSLLPLKRKLWVTPSSENPNGATSSVSQGKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
Protein: Prolyl 4-hydroxylase subunit alpha-1 (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) (Q5VSQ6)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319}.
Interaction partners:
Sequence:
MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
Protein: UV radiation resistance associated protein (UV radiation resistance-associated gene protein) (Q7ZV88)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MNSIAGRDLSVSAGSVSGNPGATSSRVLHVELTSQQRRLRHLRSIAARNIVNKNGSPLLDTYFTLHLCQDDQISRDFYKSEVIRDSLNPTWRSLDFAMLPDLLDTSVSCFVVRIWGGREEHYQLLIEWKVNLDGLRFTGQQIRSRNPNEIIFGLNDGYYAAEFDQKESSDRRKNSLLQVTVQKIGKEIEEKLRTTASCTEKKKERECMQLRIGILRCELERQKKALTREMDVMQKERAQLVKKEEASSTKQQDLESERTTLTDLQKECTAKRELFLKSKAQLTFRCRQLISELSYIYPIDVNNQNDYVICGVKLPNSEDFQAKDDGSIAVALGNTAHLVLMISCFLQIPLRYPVIHKGSRSTIKDTITDKLTEKEREFPLYPRGERFQFEYGVYLLNKNIAQLRYQHGLSTPDLRQTLPNLKNFLEHGLLVRCDRHHASMSIPVPLKSHLSVSTASEVGFPALSSSPEQDVRRRAASDADKQKCRTPPPSYNTAMAQPDPMTTPELQSEPSVEVLEVGKAVETLEDGETVSEEHPEKPLDVPTDIVSTLPSDSIPQHPGAMNGSAVPTSGGVGLGVASGGEVCCSVEQAEEIMGTEATGLGLGLGGGARLDDYPCIPVEHAVAVECDEQVLGEFDAAGIEEVSRRIYALENMSSFRRPRKNSEK