wanglab/gogpt-training-data huggingface dataset:
Protein: Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) (Q14116)
Organism: Homo sapiens (Human)
Function: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:9334240}. Secreted {ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:37993712, ECO:0000269|PubMed:37993714}. Note=The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744, PubMed:37993712, PubMed:37993714). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744, PubMed:37993714). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1, CASP4 or CASP5 during maturation (PubMed:33883744, PubMed:37993714). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:37993712, ECO:0000269|PubMed:37993714}.
Interaction partners:
- Interleukin-18 receptor 1
- Interleukin-18 receptor accessory protein
- Interleukin-18-binding protein
- Caspase-1
- Interleukin-1 alpha
- Apoptosis-associated speck-like protein containing a CARD
- Interleukin-1 beta
- Nuclear factor NF-kappa-B p105 subunit
- Interleukin-6
- Caspase-4
Sequence:
MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED
Protein: Endonuclease III homolog 2 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2) (DNA glycosylase/AP lyase 2) (Endonuclease III-like glycosylase 2) (Redoxyendonuclease 2) (Q08214)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines, but also purine-derived lesions, alkylation damage as well as abasic sites. Can also repair the oxidation products of 8-oxoguanine.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:10207101, ECO:0000269|PubMed:10471279, ECO:0000269|PubMed:19029246}. Note=Exclusively nuclear and not responsive to changes in either nuclear or mitochondrial oxidative stress.
Interaction partners:
- Apurinic-apyrimidinic endonuclease 1
- DNA-
- Endonuclease III homolog 1 lyase 1)
- N-glycosylase/DNA lyase
- DNA mismatch repair protein MLH1
- Uracil-DNA glycosylase
- DNA polymerase zeta catalytic subunit
- DNA repair protein RAD14
- DNA repair protein RAD1
- Flap endonuclease 1
Sequence:
MREESRSRKRKHIPVDIEEVEVRSKYFKKNERTVELVKENKINKDLQNYGGVNIDWIKALKPIEYFEWIESRTCDDPRTWGRPITKEEMINDSGAKVPESFLPIYNRVRLMRSKVKTPVDAMGCSMIPVLVSNKCGIPSEKVDPKNFRLQFLIGTMLSAQTRDERMAQAALNITEYCLNTLKIAEGITLDGLLKIDEPVLANLIRCVSFYTRKANFIKRTAQLLVDNFDSDIPYDIEGILSLPGVGPKMGYLTLQKGWGLIAGICVDVHVHRLCKMWNWVDPIKCKTAEHTRKELQVWLPHSLWYEINTVLVGFGQLICMARGKRCDLCLANDVCNARNEKLIESSKFHQLEDKEDIEKVYSHWLDTVTNGITTERHKKK
Protein: Slowpoke 2, isoform O (A0A0B4KEJ9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSRLIQPRYRFRDLLLGDFSFNDDGERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYGCEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATASENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQDTSNADTSHVSNSPVERWGPFSAFSRHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLADEARDNHAQQIERAEIANLVRSRMESLNLPTIDYDDVSEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQKTFERHNSRRKSNISFCSNINLGATCGPQMPQMNMNMANTAVGAGSRRGSGIAGLNPMQMQSVQTLAGYGSSSQRCSPPMQQIKSNSLSLPDSPTVVGNQRGRSNSLRIDNDILLRRSSSLRQGLPSVGVSHGRRKSSLEEIGISHFTTLMQATNHSNPIKISLNGSIGMENQISLQVTPPEEPTPMLGVPCMLGGGGGGGINPSGAGSSTGGMLGGGSSLAINTADLGPGPSTSSGASGSLQAQDSLGQQSSQVSSPQHLQGTIVXYNLMWGRRLRSSMSKNKWI
Protein: Polyprenyl synthetase (A3MSH1)
Organism: Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)
Interaction partners:
- Isopentenyl phosphate kinase
- Tritrans,polycis-undecaprenyl-diphosphate synthase
- Isopentenyl-diphosphate delta-isomerase
Sequence:
MDVVSRLHQKYGAEVEKALVRYLSIGLAEDFREAVLYQVKTGGKRLRPLLTLAAAEAVSGQWRPALPAAAIVELIHNYSLIYDDIIDRGDVRRGLPTVRKAFGDNAAILVGIWYREAIEEAVLDTPKPTLFAKEVAEVIKAIDEGERLDILFEAAGRSDPYFVQARWREVTLDDYIKMVSLKTGALIAAAAKWGVLSVSDDRGLAEAAWNFGMAAGVAFQIIDDVLDIYGDPKKFGKEIGKDIKEHKRGNAVVAVALSHLGEGERRRLLEILAREVVEEADVREAVALLDSVGAREEALRLAARYREEAERHLAKIPNNGTLKELLDFIVAREY
Protein: Ethylene-responsive transcription factor ERF070 (Q9C995)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Histidine-containing phosphotransfer protein 5
- Alcohol dehydrogenase transcription factor Myb/SANT-like family protein
- WAT1-related protein At2g37450
- WAT1-related protein At3g02690
Sequence:
MKRIIRISFTDAEATDSSSDEDTEERGGASQTRRRGKRLVKEIVIDPSDSADKLDVCKTRFKIRIPAEFLKTAKTEKKYRGVRQRPWGKWVAEIRCGRGACKGRRDRLWLGTFNTAEEAALAYDNASIKLIGPHAPTNFGLPAENQEDKTVIGASEVARGA
Protein: Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NADH-ubiquinone oxidoreductase 17.0 kDa subunit) (Q9N2W7)
Organism: Caenorhabditis elegans
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase iron-sulfur protein 4
- NADH-ubiquinone oxidoreductase 75 kDa subunit
- NADH dehydrogenase iron-sulfur protein 5
- Acyl carrier protein
- NADH dehydrogenase 1 alpha subcomplex subunit 7
- Complex I-49kD
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MSLKAWLGIDKIQKFGQMVKEIGGVKAVLKKRYLMDATRVGTLVGSDNFGNRYYENNAYFVPRNRWVEFPDKVWLDYDATQVPPEWHSWLHHITDDAPSVKPPPTQDWVLEHKENTSIYADKKYVPYSTTRTKIQGWQPGEKPQFD
Protein: Senescence-specific cysteine protease SAG39 (EC 3.4.22.-) (Cysteine proteinase SAG39) (Protein SENESCENCE-ASSOCIATED GENE 39) (Q7XWK5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Cysteine protease that may have a developmental senescence specific cell death function during apoptosis, heavy metal detoxification, and hypersensitive response.
Subcellular location: Vacuole {ECO:0000250|UniProtKB:Q9FJ47}. Note=Localized in senescence-associated vacuoles (SAVs) with intense proteolytic activity that develop in the peripheral cytoplasm of mesophyll and guard cells. {ECO:0000250|UniProtKB:Q9FJ47}.
Interaction partners:
- Os07g0295200 protein
Sequence:
MAMAKALLFAILGCLCLCSAVLAARELSDDAAMAARHERWMAQYGRVYRDDAEKARRFEVFKANVAFIESFNAGNHNFWLGVNQFADLTNDEFRWMKTNKGFIPSTTRVPTGFRYENVNIDALPATVDWRTKGAVTPIKDQGQCGCCWAFSAVAAMEGIVKLSTGKLISLSEQELVDCDVHGEDQGCEGGLMDDAFKFIIKNGGLTTESNYPYAAADDKCKSVSNSVASIKGYEDVPANNEAALMKAVANQPVSVAVDGGDMTFQFYKGGVMTGSCGTDLDHGIVAIGYGKASDGTKYWLLKNSWGTTWGENGFLRMEKDISDKRGMCGLAMEPSYPTA
Protein: Cyclin-A2-2 (Cyc3b-At) (Cyclin-3b) (G2/mitotic-specific cyclin-A2-2) (CycA2;2) (Q147G5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinase B2-2
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinase A-1
- Cell division control protein 6 homolog
- Wee1-like protein kinase
- Cyclin-dependent kinases regulatory subunit 1
- Transcription factor E2FC
- Anaphase-promoting complex subunit 10
Sequence:
MYCSSSMHPNANKENISTSDVQESFVRITRSRAKKAMGRGVSIPPTKPSFKQQKRRAVLKDVSNTSADIIYSELRKGGNIKANRKCLKEPKKAAKEGANSAMDILVDMHTEKSKLAEDLSKIRMAEAQDVSLSNFKDEEITEQQEDGSGVMELLQVVDIDSNVEDPQCCSLYAADIYDNIHVAELQQRPLANYMELVQRDIDPDMRKILIDWLVEVSDDYKLVPDTLYLTVNLIDRFLSNSYIERQRLQLLGVSCMLIASKYEELSAPGVEEFCFITANTYTRPEVLSMEIQILNFVHFRLSVPTTKTFLRRFIKAAQASYKVPFIELEYLANYLAELTLVEYSFLRFLPSLIAASAVFLARWTLDQTDHPWNPTLQHYTRYEVAELKNTVLAMEDLQLNTSGCTLAATREKYNQPKFKSVAKLTSPKRVTSLFSR
Protein: FHA domain-containing protein DDL (Protein DAWDLE) (Q8W4D8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. May facilitate DCL1 to access or recognize primary miRNAs. Binds RNA non-specifically.
Subcellular location: Nucleus {ECO:0000269|PubMed:16679419}.
Interaction partners:
- At1g31870
- Transmembrane protein
- Zinc finger CCCH domain-containing protein 42
- Nuclear protein-like
- Nuclear cap-binding protein subunit 1
- SNW/SKI-interacting protein
- Splicing factor SF3a60 homolog
- Peptidyl-prolyl cis-trans isomerase CYP57
- At2g32600/T26B15.16
- Cell division cycle 5-like protein
Sequence:
MAPSSRSPSPRTKRLRRARGEKEIGRSREREDDGREREKRNSRERDRDIGRDRDRERKGEGERDREVGDKRRRSGREDTEKRRRTRTDDERYSRGRHERSTSPSDRSHRSSRRSPERAIASRHDEGSNARGGSEEPNVEEDSVARMRAVEEALAAKKKEEPSFELSGKLAEETNRYRGITLLFNEPPEARKPSERWRLYVFKDGEPLNEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQHAVIQYREMEKEKPDGMMGKQVKPYIMDLGSTNKTYINESPIEPQRYYELFEKDTIKFGNSSREYVLLHENSAE
Protein: Histone-like protein Hns (L7N5I3)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MPDPQDRPDSEPSDASTPPAKKLPAKKAAKKAPARKTPAKKAPAKKTPAKGAKSAPPKPAEAPVSLQQRIETNGQLAAAAKDAAAQAKSTVEGANDALARNASVPAPSHSPVPLIVAVTLSLLALLLIRQLRRR
Protein: Uncharacterized protein C19G7.18c (Q7Z995)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Mitochondrion {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized protein C16C6.03c
Sequence:
MDFFWERMLNDPQNHFSDDQKEFLNHAKYRVKRNTIFGMLVGFSLPLYLARNKKVTPIRLYATSIIGGLAGNGVAQITTLAYNLSAIRQRDDGFEILRKIQDSLIRQRTTMRQGRFPSSSSEFPPKNSKYQLPGSMPNTGASSSQDPFTNSQSTEKEDAMYSKDNGFEDRSKPASAWEAIRNRNRNTGNNSFPFYEEDSSVKSTDSAFSGQENSEAFPSRTSNLGSEQLDEPISHEQEAFDQLIWNDSSSSK
Protein: Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel) (Transient receptor protein 6) (TRP-6) (Q61143)
Organism: Mus musculus (Mouse)
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9Y210}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Podocin
- Nephrin
- Protein orai-2
- Transient receptor potential cation channel subfamily V member 4
- Short transient receptor potential channel 3
- Stromal interaction molecule 1
- Bone morphogenetic protein receptor type-2
- cGMP-dependent protein kinase 1
- cGMP-dependent protein kinase 2
- Transient receptor potential cation channel subfamily M member 4
Sequence:
MSQSPRFVTRRGGSLKAAPGAGTRRNESQDYLLMDELGDDGYPQLPLPPYGYYPSFRGNENRLTHRRQTILREKGRRLANRGPAYMFNDHSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAILNGDAETRQPGDFGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMCELIQGQKQGFQEDAEMNKRNEEKKFGISGSHEDLSKFSLDKNQLAHNKQSSTRSSEDYHLNSFSNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRKLGERLSLEPKLEESRR
Protein: LD30158p (Q95T03)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVVLGMAHEYRHGYQHMLQKSDVLIKCMQGTQVVWLQNSAGYARWGPNEIRVEALREAFRPQRDRERERAAAAAAAAGVTSSQQSPSTPPSAASTAPTTNSCTISGVNSNSSSTATTTSTSSSPSLTTTSSSMSPLSPHTPTGNPPPQFPMTISNTSSSSNLVAASPTMSVQSDCSSPSSSTMSLSPAPASGGYPDGVTSATAAAVSITATTTTSAAGAGSAFGQANSISSSASTQAVINSAV
Protein: Leucine rich repeat containing 7 (A0A075B6E9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQCLEMTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFVAEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSNPNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYPPMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPTDRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV
Protein: Tetratricopeptide repeat (Q585Z1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Large ribosomal subunit protein uL29m
- KOW domain-containing protein
- 39S ribosomal protein L28
- LIM zinc-binding domain-containing protein
- Large ribosomal subunit protein mL43
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Large ribosomal subunit protein mL46
Sequence:
MSRNAFSSRGALLFSSAPLQCQRRWVTRLYTSYYTGVLYPNQLVQPKQRLPADVSVSAILQKRSELEAAAKRGSNKGNKVDVSKGEKTPGVSWDDADSTDVMRVDNTQQLKEAPQVERPYVPLGEVAKLELQGDYYMEGGMFQEALEHYGVVAKAYNYAYPENHAQRIGIRIKLSAAFRQTGRLESSLANIEEVLRMLDASTRPSLELICEALLELGITREALGMKREATEAYEEALEVVNSFHNWGESHRMLRLLPRLGRRFNYNFEEKFVYFSPFDYDRTFALVDQCLERAETTFNEIGDVEGAIRVLQQRKEMIDKKFFNMRDFAGRIHTMRGHWKRRAQHLTNAPTPDELLRYSPTIHQVHRDFKFELTAPIGREKEVMPGVNRLVLDMGNPYRRRGRLSNKMLKDADHKFANYVRQKEYNE
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q7JWT4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Axin
- Armadillo segment polarity protein
- Protein smoothened
- Transcriptional activator cubitus interruptus
- Kinesin-like protein costa
- MIP21552p
Sequence:
MAEREKGRAKDDRRWQGRSDVHQSKPQIRKERRHPPQPNHPHEKDQRQDRRFSEEKQSLPEIIVAGKYRLLKRIGNGSFGELFQAEGLKYHEKVAIKLESSTVKHPLLPREARIYGILQGGLGIPHVKHYATEGAYNVMVMDLLGPTLEDLLNLCSRSFSMKTTLMLADQILARVELLHRRCFIHRDIKPDNFLMGLNRHQTQVYMIDFGLAKKFYSLRTQKHIGYTENRDLVGTARYASVRAHYAEQSRRDDLESVGYLLLYFQRGRLPWQGIRAQSQAQKYEKIAEYKANIPLQQLCSGLPVEFFMYLKYCRKLHFAEKPDYVYLQQLFKVLFRNQYKVCDFLFDWVVLKRESPEQQSQQKGRERDRGGKRNVVVQKERHRNKDRDSDTQRCRIKNGGDLLEIEENESTTGEDPNEDKPQKKHGKACSCSYHLQKKRLQDRDRRAPLMTERRILSGEQEQELELELRGSPQMPCL
Protein: U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) (Q05900)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. YHC1/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-processing factor 39
- U2 small nuclear ribonucleoprotein A'
- Small nuclear ribonucleoprotein Sm D3
- Protein LUC7
- U1 small nuclear ribonucleoprotein A
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
- Pre-mRNA-splicing factor PRP9
- Small nuclear ribonucleoprotein F
- U2 small nuclear ribonucleoprotein B''
Sequence:
MTRYYCEYCHSYLTHDTLSVRKSHLVGKNHLRITADYYRNKARDIINKHNHKRRHIGKRGRKERENSSQNETLKVTCLSNKEKRHIMHVKKMNQKELAQTSIDTLKLLYDGSPGYSKVFVDANRFDIGDLVKASKLPQRANEKSAHHSFKQTSRSRDETCESNPFPRLNNPKKLEPPKILSQWSNTIPKTSIFYSVDILQTTIKESKKRMHSDGIRKPSSANGYKRRRYGN
Protein: Cbx4 protein (Q05BI5)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSADNRAKLELGTQGKGQGHQYELNSKKHHQYQPHSKERSGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGTKSHPPDKWAHGAAAKGYLGAVKPLGGGAGAPGKGSEKGPPNGMTPAPKEAVTGNGIGGKMKIVKKKKK
Protein: PLEKHA5 protein (A0JP02)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV
Protein: H(2):CoB-CoM heterodisulfide,ferredoxin reductase subunit C (EC 1.8.98.5) (CoB--CoM heterodisulfide reductase iron-sulfur subunit C) (Q50754)
Organism: Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
Interaction partners:
- H
- F420-non-reducing hydrogenase subunit G
- H
- F420-non-reducing hydrogenase iron-sulfur subunit D
- F420-non-reducing hydrogenase subunit A
- Polyferredoxin protein MvhB
- Energy-converting hydrogenase A, subunit Q
- Methyl viologen-reducing hydrogenase, subunit D-related protein
- formate dehydrogenase
- Molybdenum-containing formylmethanofuran dehydrogenase 1 subunit C
Sequence:
MTLLQREENIIRKGNIDKEFSEKIKAAGGDSLEYCFQCGTCTGSCPSGRRTPYRVRQIIRKANVGLKDEIISDPTLWMCTTCYSCQERCPRKVKIVDVVKLARNEAAKAGFMAPAHKAVGSFVIKTGHGVPINDATMELRKAVGLGELPPTTHQFPEALEEVQKIIKATGFDQLIGYNWETGELE
Protein: Prion-like-(Q/N-rich)-domain-bearing protein (Q21344)
Organism: Caenorhabditis elegans
Interaction partners:
- Apple domain-containing protein
- SUppressor of Pkc-3
- Fungal lipase-like domain-containing protein
- Secreted protein
- Apple domain-containing protein
- Titin
- MliC domain-containing protein
- Non-specific serine/threonine protein kinase
- MSP domain-containing protein
- Uncharacterized protein
Sequence:
MRRLLIHLVVLLVLLLEGHNVLGFASAPGTYPEEETRAGNDMEVPKNPYESTWTGYDFYYEKEPKKVPPSAGSGKMPAFQSIASISTDRESPEDPGNSGYLASGAESGPKKTTSKPATTPTPEPTTTPVEEEKVKVSPSSSTKDPSKLHKTTKTPVTITNIISTTTAPPAPSRAPENDPESGSDQSESTDNLDLLYGGGSSATATGEDKKDPPKLHDPPPPHPSAPQNLLTQLIQKKKDAPNKGSSEKSSKWSDDHASGYPEGSAPSAEPSENQYEQDGSIPSSNDYKELTDVPGTKPSSSASRGSNMAGNPTAPLTTTQHTFAPNSTETSRSSTSRGKAPGTEPKSEARYSSQNPYSDNSSTQKPEYESGYPAVSGANSRAQIPNITDYTKPSAVSIEYASSSKERSDPPFSTPLTSNSQHVLTQPRPRDYEDGPQETTRTKASGTKSPNSLQAPQQTAAHLMKNARAPGPEPSLHSTTTHHVQTPIITIAPKFSEPSPYAENIMLTPKQAPGTEPRSNSQNPQTDRLASQSGYESGGPGRPQNVSIRHRENPKGSDAISRTAITPSKIDYFAPSSPTGPIGYERQVPSFKEGPDHQYTKYSTLNSPPAPSPQESSTITHHVSTSPDFLEPSSESSVLLPKQAPGTNPSTSNSPPGYSELIGPSGPGNGLPEAPSHAAQNIPRAHTFSESQGYEPMGNNGPSIFEGPGTESGYSEPKALSTASQKTKPDDKPYEIPRSIEPSNSKPYPSDSSWSDHDNAPGSEPSYIPDVLDYGARANNHAGKMMNMSHATSPSTGSPSNSNNAISARDPYDHFGTITAPSDIPRANSNFEEYPDDGGYDGTNDVAIVPLRTQHGTNPSTITTTNTQVRAQISEIDRIAESFENSAREPVEYEQRITSESSKGITAVTGKDFMKKLGRKSPTCCSCCDEKQSVSRNIETQADPLHVQHAVDPSRQLVESEPVQNFVPLQNTVGGNAYIQPQPVAQQQTIYQQPFQQYQPQYPQSYQQPSCGCQPQPQNCCAPPAPCCLPTIPCCPPIPCCPQPKICCQPAPVCLPPPTCCSINFKLPTIPICGRACPSCPCRRRMHKSRRLKRHSINSNCHQCSSAGEPWRSVLHHREKRAAPGCTSGFSTMSQNSCGTCGASNLRSPRVKRMGCLPCLGRKKRDTDENSHIRVKRMGCLPCLGRKKRSTLSQSGCSQCNSMGHLFNRYKRSLFGGCSPCAPQQPCGCGRKKRSVTMKLVKRAPMQCDSTCCDFSRCPYRQKKEALVPFM