wanglab/gogpt-training-data huggingface dataset:
Protein: Pyruvate dehydrogenase E1 component subunit beta (EC 1.2.4.1) (C9J634)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGISKKLVLEYSQAIVNIMYLNTYRIKRLKARSGQTTSTLNLSCVQFPGCSCCSCHWC
Protein: Phosphatidylinositol-4-phosphate 5-kinase (Q384V3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell projection, cilium, flagellum {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000256|ARBA:ARBA00004430}.
Interaction partners:
Sequence:
MTTKEAVVQIYRYLKAVCTDRVSSNTVPTTAVRKYVGEVDDDNLFHGHGALVSAMGFIYEGTFVHGCMEGHGRISWANGVSYEGSFHNNAPHGIGVLTKANGDRYAGEVYKGVYHGYGESTTATGVYNGQWRYGKRHGKGRQTYANGGSYYEGEWAENMRHGSGKLLYPNGDLYDGMWVNGKRHGHGSMGWKSGTAYYVEVYEGEWYEGVPQGFGRSTYVHYIDPSRATPDTEGPATFAHPSCAVINVYEGEFANGKRNGFGTFYYADGSTYEGTWRDGNKFGRGKCITNAGSSYYGTFDCNEMDLPPGDMSSDPLPSVTLTDLVNVSDGSTEHAASSIRLLVLRFNNPLKDIFTDYCGKQRGIKFVTTHTEWWRHRLPGHLCIPQFLRLLNDARIINGYITIGVAVDCVVTTLEEEEKKDHSEPVDQRSGRLRKLRSEVLRLDGCINYRQFVESLVRLSAKTCIGPNFAELSRQFTTIVERLLDKKHIAEEPLCPVTREYEAILTKDIVHRLEHLYFQLAEDAVPDLRGTAAVLTAHNFILFFHDKLDSCNIGLVEAVNVVLPFDRFKIPGTVPSGMCQPRNAMGHSLYEKSSGPGGEFLATLVASERRLTFVEFVEAVLVTMRLAGALKPDEMCGKLLELVGTEESSHDGV
Protein: DNA-binding enhancer protein-like protein (Q9C901)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- N-terminal acetyltransferase A complex auxiliary subunit NAA15
- N-terminal acetyltransferase A complex catalytic subunit NAA10
- Acyl-CoA N-acyltransferases
- Histone acetyltransferase MCC1
- N-alpha-acetyltransferase 60
- B-box domain protein 30
- B-box domain protein 31
- Lysine-specific demethylase JMJ14
Sequence:
MEGAEEAGAEIAVDSKDLQQQSKAFDKLTDRVEDRQLDSSRVQSAMASIAASREADLNAKRLREKELASVKINPADVEFIVNELEIEKNVAERTLREHKGDAVAATRQLLSRYPL
Protein: Predicted gene 43302 (L7N1X8)
Organism: Mus musculus (Mouse)
Interaction partners:
- Predicted gene 43638
Sequence:
MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKDALLNGFSTVLFHYLVRYLKHL
Protein: RH64870p (Uncoupling protein 4A, isoform A) (Uncoupling protein 4A, isoform B) (Q9VX14)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Mitochondrial uncoupling protein Bmcp
Sequence:
MAAKTDESSPAVASSTSSNPAPSSGRHQLRPVKFDYADSFACTYIVSVVAASIAELATYPLDLTKTRLQIQGEGAAHSAGKSNMQYRGMVATAFGIAREEGALKLWQGVTPALYRHVVYSGVRICSYDLMRKEFTQNGTQALPVWKSALCGVTAGAVAQWLASPADLVKVQIQMEGRRRLMGEPPRVHSAGHAFRQIVQRGGIKGLWKGSIPNVQRAALVNLGDLTTYDTIKHLIMNRLQMPDCHTVHVLASVCAGFVAAIMGTPADVVKTRIMNQPTDENGRGLLYRGSVDCLRQTVSKEGFVALYKGFLPCWIRMAPWSLTFWLSFEQIRKMIGASGY
Protein: Endoplasmic reticulum vesicle protein 25 (Q5A302)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Recycles between endoplasmic reticulum and Golgi. {ECO:0000250}.
Interaction partners:
- Emp24p
- Erp5p
- GPI inositol-deacylase
- GPI ethanolamine phosphate transferase 2
- GOLD domain-containing protein
- Mitochondrial 37S ribosomal protein MRPS35
- Coatomer subunit delta
- Succinate dehydrogenase assembly factor 2, mitochondrial
- Small ribosomal subunit protein RACK1
- Small COPII coat GTPase SAR1
Sequence:
MQSLITYIALVFSLFVSSAIGLHLEVPALPNPQPVCIRDFVQENQMVVVNIKTDGSKGDGQRLDLKVTDSLGNEYRNKKDVVGHANVAFTSQHNAAIDICLTNYLDNKWSKHQQTVRSVELDIESGAAARDWNALQASEKLKPVEVELKRIESITEEIVEELRYLKAREERMRDTNESTNSRVKWFSIVVIASLVGFGVWQIQYLRHYFKVKHII
Protein: Zinc finger protein GIS2 (Protein GLABROUS INFLORESCENCE STEMS 2) (Q9FG05)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin. Is not involved in the regulation of trichome branching. Is functionally equivalent to ZFP8.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9SLB8}.
Interaction partners:
- Transcription factor GLABRA 3
- Transcription factor MYB23
- MYB-like transcription factor TCL1
- Homeobox-leucine zipper protein GLABRA 2
- MYB-like transcription factor TCL2
- Transcription factor EGL1
- MYB-like transcription factor ETC2
- MYB-like transcription factor ETC1
- Transcription factor TRY
- MYB-like transcription factor ETC3
Sequence:
MKTYDFMNVNSFSPKERPIRLFGFEFGASHEESESKDNYNENNESIKDDNKEKRFKCHYCFRNFPTSQALGGHQNAHKRERQQTKRFNLHSNAAAFFHRQQNHIAASRLYEDRYSLEAVQINDARLGLCRMYNSSASFNRDRSSYYNRYIPWFIGDHQTRPTYVGGGSSSHGLFYESKKNVPDHVSLDLRL
Protein: Protein CURLY FLAG LEAF 1 (OsCFL1) (Q0E0W7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Regulates negatively the cuticle development probably by interacting with the HD-ZIP IV transcription factor HDG1.
Interaction partners:
Sequence:
MTAPNIEMIASSLRNCSLNGGGGGGGGRRRGRRAAAAEGSDDSEGVTVELNSEVALPYHWEQCLDIRTGQVYYINWEDGTRTTIDPRSSSAYSPSPASRSASSSSRRCSRARGRGGGGGAAAAASTTTSSGYTSVSSVGAVTAAAAAWRSHDSSGHGYGYGYGYGSYGYGYGYDGRDGDDEESSSSSSSSSSSSSSASSSRGSAVSSTLSSFSPTDESASGAGSGYAVGDNGAHVLVAAGCRACFMYFMVPKTADVCPKCGSSGLLHLSRNGYV
Protein: AP2-like ethylene-responsive transcription factor CRL5 (Protein CROWN ROOTLESS 5) (Protein PLETHORA 8) (OsPLT8) (Q84Z02)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Acts as positive regulator of adventitious (crown) root formation by promoting its initiation. Promotes adventitious root initiation through repression of cytokinin signaling by positively regulating the two-component response regulator RR1. Regulated by the auxin response factor and transcriptional activator ARF23/ARF1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366}.
Interaction partners:
Sequence:
MTNSNNGNGGTNAAASGWLGFSLSPHMASSTMDEHHHVHHHQQQQQQQQQQQHHQQQQHGLFFPSVTTAAAAAAYGLAGDVVAATNGYYSQLASMPLKSDGSLCIMEALRRTDQDHHGPKLEDFLGAAQPAMALSLDNTSSFYYGGGGAAAAGHGQHGYLQACDLYGGPAAPSLVTAADEEAAAAAAAMASWVAARGAATAYATGAADANAAENVLPSATAAQHLHHPLALSMSSGSLSSCITAGEYGMAAVAAADGGRKRGGAGGGGQKQPVHHRKSIDTFGQRTSQYRGVTRHRWTGRYEAHLWDNSCKKEGQTRKGRQGGYDMEEKAARAYDLAALKYWGPSTHINFPLEDYQEELEEMKNMTRQEYVAHLRRKSSGFSRGASMYRGVTRHHQHGRWQARIGRVSGNKDLYLGTFSTQEEAAEAYDVAAIKFRGLNAVTNFDITRYDVDKIMASNTLLPADLARRNAATTTSKDDHSAAGAGAIVSVHSAADIAVADTLWKATTAPRQQQQHHDDVVLSGADQAAFSVLHDLVAVDAAAAHQQQQQQQHMSMSAASSLVTSLSNSREGSPDRGGGLSMLFAKPSPAVAASAQQQASTKLMAAPLPLGSWVSSPPASARPPAVSIAHMPLFAAWTDA
Protein: Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) (Q13033)
Organism: Homo sapiens (Human)
Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:18782753}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Striatin-interacting protein 2
- Programmed cell death protein 10
- Striatin-interacting protein 1
- Striatin-4
- Striatin
- MOB-like protein phocein
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- CTTNBP2 N-terminal-like protein
- Suppressor of IKBKE 1
Sequence:
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRSSGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV
Protein: Secreted frizzled-related protein 3 (Frizzled-related protein 1) (FrzB-1) (Q32N13)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSTTRNKDTFQLLVIPWLVLLLLPSAFCASCEPVRIPMCKSMPWNMTKMPNHLHHSTQANAILAIEQFEGLLTTECSQDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGCEPILIKYRHTWPESLACEELPLYDRGVCISPEAIITVEQGTDSMPDFSMDSNKGNCGSTAGEHCKCKPMKASQKTYLKNNYNYVIRAKVKEVKVKCHDATAIVEVKEILKSSLVNIPKDTVTLYTNSGCLCPQLVANEEYIIMGYEDKERTRLLLVEGSLAEKWRDRLAKKVKRWDQKLRRPRKSKDPVASNTNKNSNSRQAHS
Protein: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.21.10) (Holliday junction nuclease RuvC) (Holliday junction resolvase RuvC) (O25544)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00034}.
Interaction partners:
- Holliday junction branch migration complex subunit RuvA
- Holliday junction branch migration complex subunit RuvB
Sequence:
MRILGIDPGSRKCGYAIISHASNKLSLITAGFINITTTRLQEQILDLIEALDCLLDRYEVNEVAIEDIFFGYNPKSVIKLAQFRGALSLKILERIGNFSEYTPLQVKKALTGNGKAAKEQVAFMVKRLLNITSEIKPLDISDAIAVAITHAQRLKLH
Protein: Dynein axonemal assembly factor 3 (Q8N9W5)
Organism: Homo sapiens (Human)
Function: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.
Subcellular location: Cytoplasm {ECO:0000250}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q32NQ7}.
Interaction partners:
- Dynein axonemal assembly factor 4
- Dynein axonemal assembly factor 1
- Dynein axonemal assembly factor 5
- Zinc finger MYND domain-containing protein 10
- Dynein axonemal assembly factor 11
- Dynein axonemal intermediate chain 2
- Dynein axonemal assembly factor 6
- Dynein axonemal assembly factor 19
- Coiled-coil domain-containing protein 39
- Cilia- and flagella-associated protein 298
Sequence:
MTTPAGSGSGFGSVSWWGLSPALDLQAESPPVDPDSQADTVHSNPELDVLLLGSVDGRHLLRTLSRAKFWPRRRFNFFVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLEVWGNALLRPPVAAFVRAQADLLAHLVPEPDRLEEQLPWLSLRALKFRERDALEAVFRFWAGGEKGPQAFPMSRLWDSRLRHYLGSRYDARRGVSDWDLRMKLHDRGAQVIHPQEFRRWRDTGVAFELRDSSAYHVPNRTLASGRLLSYRGERVAARGYWGDIATGPFVAFGIEADDESLLRTSNGQPVKTAGEITQHNVTELLRDVAAWGRARATGGDLEEQQHAEGSPEPGTPAAPTPESFTVHFLPLNSAQTLHHKSCYNGRFQLLYVACGMVHLLIPELGACVAPGGNLIVELARYLVDVRQEQLQGFNTRVRELAQAAGFAPQTGARPSETFARFCKSQESALGNTVPAVEPGTPPLDILAQPLEASNPALEGLTQPLQGGTPHCEPCQLPSESPGSLSEVLAQPQGALAPPNCESDSKTGV
Protein: Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) (O46043)
Organism: Drosophila melanogaster (Fruit fly)
Function: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism is required for maintenance of the normal function of neuronal cells.
Interaction partners:
- Poly [ADP-ribose] polymerase
- FI04011p
- Blue cheese
- ADP-ribose glycohydrolase OARD1
- Proliferating cell nuclear antigen
- Proliferating cell nuclear antigen 2
Sequence:
MSKSPDGGISEIETEEEPENLANSLDDSWRGVSMEAIHRNRQPFELENLPPVTAGNLHRVMYQLPIRETPPRPYKSPGKWDSEHVRLPCAPESKYPRENPDGSTTIDFRWEMIERALLQPIKTCEELQAAIISYNTTYRDQWHFRALHQLLDEELDESETRVFFEDLLPRIIRLALRLPDLIQSPVPLLKHHKNASLSLSQQQISCLLANAFLCTFPRRNTLKRKSEYSTFPDINFNRLYQSTGPAVLEKLKCIMHYFRRVCPTERDASNVPTGVVTFVRRSGLPEHLIDWSQSAAPLGDVPLHVDAEGTIEDEGIGLLQVDFANKYLGGGVLGHGCVQEEIRFVICPELLVGKLFTECLRPFEALVMLGAERYSNYTGYAGSFEWSGNFEDSTPRDSSGRRQTAIVAIDALHFAQSHHQYREDLMERELNKAYIGFVHWMVTPPPGVATGNWGCGAFGGDSYLKALLQLMVCAQLGRPLAYYTFGNVEFRDDFHEMWLLFRNDGTTVQQLWSILRSYSRLIKEKSSKEPRENKASKKKLYDFIKEELKKVRDVPGEGASAEAGSSRVAGLGEGKSETSAKSSPELNKQPARPQITITQQSTDLLPAQLSQDNSNSSEDQALLMLSDDEEANAMMEAASLEAKSSVEISNSSTTSKTSSTATKSMGSGGRQLSLLEMLDTHYEKGSASKRPRKSPNCSKAEGSAKSRKEIDVTDKDEKDDIVD
Protein: Ly6/PLAUR domain-containing protein 4 (Q6UWN0)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
Sequence:
MGPQHLRLVQLFCLLGAISTLPRAGALLCYEATASRFRAVAFHNWKWLLMRNMVCKLQEGCEETLVFIETGTARGVVGFKGCSSSSSYPAQISYLVSPPGVSIASYSRVCRSYLCNNLTNLEPFVKLKASTPKSITSASCSCPTCVGEHMKDCLPNFVTTNSCPLAASTCYSSTLKFQAGFLNTTFLLMGCAREHNQLLADFHHIGSIKVTEVLNILEKSQIVGAASSRQDPAWGVVLGLLFAFRD
Protein: Voltage-gated inwardly rectifying potassium channel KCNH7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (Potassium voltage-gated channel subfamily H member 7) (Voltage-gated potassium channel subunit Kv11.3) (O54852)
Organism: Rattus norvegicus (Rat)
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q12809}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12809}.
Interaction partners:
- Voltage-gated potassium channel subunit beta-3
Sequence:
MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFEYVTDEDNAASPERVNPILPVKSVNRKLFGFKFPGLRVLTYRKQSLPQEDPDVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSQCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLTHSRSRESLCSIRRASSVHDIEGFNVHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSDVKTEKKNTSPPSSDKTIIAPKVKERTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAVHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGTQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLRHESAKSQSINDSEGDTCKLRRRRLSFESEGDKDFSKENSANDADDSTDTIRRYQSSKKHFEEKKSRSSSFISSIDDEQKPLFLGTVDSTPRMVKASRHHGEEAAPPSGRIHTDKRSHSCKDITDTHSWEREHARAQPEECSPSGLQRAAWGISETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQAILQLLQKQTTVVPPAYSMVTAGAEYQRPILRLLRTSHPRASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGKRLNTASEDNLTSLLKQDSDASSELDPRQRKSYLHPIRHPSLPDSSLSTVGILGLHRHVSDPGLPGK
Protein: Protein BCK2 (Bypass of kinase C protein) (P33306)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Dosage dependent suppressor of PKC1 deletion and MPK1 deletion. Involved in cell lysis.
Interaction partners:
- G1/S-specific cyclin CLN3
- Regulatory protein SWI4
- Transcription factor MBP1
- G1/S-specific cyclin CLN1
- G1/S-specific cyclin CLN2
- Zinc finger protein RME1
- APC/C activator protein CDH1
- G1-specific transcriptional repressor WHI5
- Cyclin-dependent kinase 1
- Regulatory protein SWI6
Sequence:
MPKNSHHHRSSSVNSTKSRSTESTNKWKIPHYYRRSASGSTQASPDRNSSTGSCSTPVLPTMNVMSSPKKVLLEDPRDNHTKAKKSSRKKSGEMVFVNYTVQDTANENDTDLQTQPVSVPAPKAKLKKKSSKRRMLKIFGSSKNEHIEDIVEEQPMVLQMDSESKPLSGTPISESGIDASSLTTKRSYNSFLKHNRLNGKTPFSGNLSFPSLNMMGNTTDLPIDNNDFCSEKEVVPKSTHDPSLAKPPSRFTESETNSTPNLSSIPLMNTKNTRLKYNKVAPQSSDRQKSQESGLYHSTESFNFKDQNYSNNKSSLSLNSDLSTPHFAKHSPDSPRTSRSFNCGDSQSKVKLPEENDASIAFSKMFTRKRANTGGSTCSLASPTIAQTIQQSNIKVNKLPTQRTTSVGSLSSMSNRYSPIRVASPGRARSATRGSSLYRLSRDLNSLPSVTDLPEMDSTTPVNEIFLDGQPQHKSGSVKGGHRKKQESISDAQRIQHSNSYITTPSSSLVTPPYYMTGYTLPSSASASSTPNVLETHNMNFVPSTSTVTSYRPSSNFSSFDKEYSNENDASGEFSAFNTPMENIPALKGIPRSTLEENEEEDVLVQDIPNTAHFQRRDIMGMDTHRKDDSLDFNSLMPHGSTTSSSIVDSVMTNSISTTTSNATGNYFQDQDKYTLVNTGLGLSDANLDHFIRSQWKHASRSESNNNTGNRVSYSGSTPNNVDTTKTNLQVYTEFDFENPESFFHEQSKLLGEMGHSNNNSNSAINMNEPKSADTYIGNISPDTSATVSLGDLMGSNVSNNSERNFYDGHTFVPQYQANSSVENSNNQNAAPIANNDIDNNLQSFYFDNSN
Protein: Probable M18 family aminopeptidase 2 (EC 3.4.11.-) (O51572)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
Sequence:
MVXXKTLEPKFFQSLLDNSPTPYHLVNYIEEKLINYFNAQQLKLNEKWKIKTGSYYIKKEGTSLIAFNIDVKKKYEPFLIAAAHTDSPGLKLKIDATEKVSGVFYNHIEVYGSPIISTWIDRDLSLAGIVYFKKNENIESKLINIENIGIIPNLAIHLNRQINEGFKYNAHDNLTVISSTKKAIKDNILEQLGIECENFLSCDLIFTESQPSKIIGTEGEFLASKNLDNKSGCHAIMNSYVHTSNDKNKIAVFFDNEEVGSLTSRGADSNFLSEVLERIDIALDLTREEHLIKTNKSFNISIDSVHGIHPGYTSKHDPNYQANLGKGVVVKNSANFRYATTSTGFAKLKNLAIKNNIKIQEIIMKANVPSGTTIGPISNARTGIETIDIGTPMWAMHSLRETVSIADHIEAIKLLRAFFEKGI
Protein: Candida glabrata strain CBS138 chromosome A complete sequence (Q6FY13)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004393}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004393}.
Interaction partners:
- Small COPII coat GTPase SAR1
- Clathrin heavy chain
- Candida glabrata strain CBS138 chromosome D complete sequence
Sequence:
MIYSLIFLCALASLSCAFTPNATSFNATESESVAVFSNSSSLLRYNSSSVLFSNNYGKNWTVLLNNTATPQRHNGSNRTFNYFDFLNSEYFDDMESYYEPEVIIDPLYSESRAFYGFKNVFYVFDAQGRNETSGPISNLTNSSMLFDVSTNVHNKSLIISNFIEVLDTKHYRGRSFISVNNGTSFREIKPSIPNLNDSVVDKFLCHFLASTPTTKFKNSSDLVCFFTSTNRGFNNTVFFSGDFGVTLQAVNLSSGIYPLDVQITDSYVIMQTANTTAANWLFNLGDDNGNSDDDSDDSDDLPPTPTVSDFPGISNFPGIPGISGFPSISGIPGISDIPHLSGIPGISGIPGIPGMPGIPGASGIPGTSGIPGASGVPGVDGVDGVPGVDGVDGIPGVDGIPGIDGISGIDGIDGAIGDLFSQISELFRTVDLYVSKDGKDFNRANIPAITYNVFSVSEIMGGKLIFSNGFSPFTLGFTEVTNSTASNSSTNVSSVFISDSTGLNFTSANISYSDSLFSQLYTFGDLNGTIIMAPLGIWNSTSKISTDNGATWNDLKVNSSSVKGNYSCIAHNNCTLQLSAILGYSKTGIMVAQGNINLTPQDFNRTFNITNLDDLYDDYNLTDIETDSDDYFDNFYLLTTTFLSKDGGMTWEQILDYSKAVALGNFGNIIVAEDNGLRNTTGFVYSLNMGATWDRLPTSVPLFSNDVISTTPDSSGLQFILTGESRRGFRNVAEVVDFSSLFNGKLCSSSSDLEQFKLNNGTCLNGSRYEINRRAPSAQCLLNINNTRWDISSC
Protein: Uncharacterized ATP-dependent helicase C582.10c (EC 3.6.4.-) (Q10332)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889}.
Interaction partners:
- ATP-dependent helicase rhp16
- DNA repair protein rad16
- DNA repair protein rdl1
- RNA polymerase II transcription factor B subunit 3
- DNA excision repair protein ckn1
- DNA damage-binding protein 1
- DNA repair protein rhp7
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH subunit tfb1
Sequence:
MEKASKNKESGVKKANNSFLQNFGVNTAGKENESTSLPRLPKSEDESIPKQSIKSKNKKKTQHFLSDAFESLKRQEIDTNEKEVIVSAPITSKPAQVFYSKKLERKDEGIRKWEKDPFAPISVKSGAWKKPYTKVPEVSINKATSKRTDLINDKPIVIPIPRASTSTLYFGKHNKPTSENRKGPIGIPTEEILTSQNTQAMLHKLFENNVLDNVKDDSMQRQSSFIPGMHIRLLDHQVQGLTWLKSRETVSKSSASGGILADDMGLGKTIQMIALILSHPLPKKKHSIKSTLVVAPLSLIKQWESEVQTKSKLTAIVYHGASRYKLLKVIHEYDVVITTYQILVSEWVSHNTTGTDGKSPTEAKSYEKKKPSLFAFYWWRIILDEAHTIKNKSSKSALACCALQGINRWCLTGTPLQNNVDELYSLVKFLHINPFNDQSVWKDQISLPLCQGEENLVFKRLRMLLSVIMLRRTKTLLEANAGKDGTGGALKLSKRLVYKVICKFEESERDFYSNLARNMERTMSNFVNSGKLGKNYTNILCLLLRLRQACNHPQSLNFQFEQDVDAFNALDGAANTNKLASDQDVDDLANLLETVEIGSRKKSFCTICMAELPPDFHEKKCKDCSRNFKELDKGIQDPNDKTLYKSSKIREILKILSLDEQEEDDTVRGLRKTIIFSQFTTFLDIIDLHLRKAGIGFVRYDGRMNNRAREKSLDLLRSDSGTQVLLCSLKCGALGLNLTCASRVILCDVWWNPAIEEQAIDRVHRIGQRRDVLVYKLVVENTIEEKIVELQNLKRDLAKQALGDGKKSVFTSKKLTLNDLLFLFNKRAAA
Protein: N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) (Synaptotagmin-interacting protein 2) (Stip-2) (Q7Z6G3)
Organism: Homo sapiens (Human)
Function: May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:F1LQY6, ECO:0000250|UniProtKB:Q91ZP9}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1LQY6}. Cell projection, axon {ECO:0000250|UniProtKB:F1LQY6}. Cell membrane {ECO:0000269|PubMed:17689978, ECO:0000269|PubMed:19694902}. Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity). {ECO:0000250|UniProtKB:F1LQY6, ECO:0000269|PubMed:17689978, ECO:0000269|PubMed:19694902, ECO:0000269|PubMed:26843217}.
Interaction partners:
- N-terminal EF-hand calcium-binding protein 3
- N-terminal EF-hand calcium-binding protein 1
- Adenosine receptor A2a
Sequence:
MCERAARLCRAGAHRLLREPPQQGRALGGLLRWVGARMGEPRESLAPAAPADPGPASPRGGTAVILDIFRRADKNDDGKLSLEEFQLFFADGVLNEKELEDLFHTIDSDNTNHVDTKELCDYFVDHMGDYEDVLASLETLNHSVLKAMGYTKKVYEGGSNVDQFVTRFLLKETANQIQSLLSSVESAVEAIEEQTSQLRQNHIKPSHSAAQTWCGSPTPASAPNHKLMAMEQGKTLPSATEDAKEEGLEAQISRLAELIGRLESKALWFDLQQRLSDEDGTNMHLQLVRQEMAVCPEQLSEFLDSLRQYLRGTTGVRNCFHITAVRLSDGFTFVIYEFWETEEAWKRHLQSPLCKAFRHVKVDTLSQPEALSRILVPAAWCTVGRD
Protein: Uncharacterized protein Rv0088 (P9WM73)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized HTH-type transcriptional regulator Rv0081
Sequence:
MSVYKHAPSRVRLRQTRSTVVKGRSGSLSWRRVRTGDLGLAVWGGREEYRAVKPGTPGIQPKGDMMTVTVVDAGPGRVSRSVEVAAPAAELFAIVADPRRHRELDGSGTVRGNIKVPAKLVVGSKFSTKMKLFGLPYRITSRVTALKPNELVEWSHPLGHRWRWEFESLSPTLTRVTETFDYHAAGAIKNGLKFYEMTGFAKSNAAGIEATLAKLSDQYARGRA
Protein: Transmembrane protein (A0A0H3LH57)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MTILTGRRMTDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVANRFYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAAAAAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPASAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPTGLTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF