wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor MYB115 (Myb-related protein 115) (AtMYB115) (Q1PDP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that recognizes the motif 5'-TAACGG-3' in the promoter of target genes. Promotes vegetative-to-embryonic transition and the formation of somatic embryos from root explants in a WUS-independent manner. Together with MYB118, activates the transcription of S-ACP-DES2/AAD2 and S-ACP-DES3/AAD3 thus promoting the biosynthesis of omega-7 monounsaturated fatty acid in seed endosperm.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:27681170}.
Interaction partners:
- Germin-like protein subfamily T member 3
- Stearoyl-[acyl-carrier-protein] 9-desaturase 2, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 3, chloroplastic
- At3g10595
- Homeodomain-like superfamily protein
Sequence:
MYHQNLISSTPNQNSNPHDWDIQNPLFSIHPSAEIPSKYPFMGITSCPNTNVFEEFQYKITNDQNFPTTYNTPFPVISEGISYNMHDVQENTMCGYTAHNQGLIIGCHEPVLVHAVVESQQFNVPQSEDINLVSQSERVTEDKVMFKTDHKKKDIIGKGQWTPTEDELLVRMVKSKGTKNWTSIAKMFQGRVGKQCRERWHNHLRPNIKKNDWSEEEDQILIEVHKIVGNKWTEIAKRLPGRSENIVKNHWNATKRRLHSVRTKRSDAFSPRNNALENYIRSITINNNALMNREVDSITANSEIDSTRCENIVDEVMNLNLHATTSVYVPEQAVLTWGYDFTKCYEPMDDTWMLMNGWN
Protein: Glucan endo-1,6-beta-glucosidase B (EC 3.2.1.75) (Beta-1,6-glucanase B) (Endo-1,6-beta-D-glucanase B) (Endo-1,6-beta-glucanase B) (Q5B6Q3)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MKFILPLFTSLPVALAWLPGIDKDIYSAAGTNIFNVTSASSKRWLPASKKIRGVNLGSHFVIEPWMASMAWSNMGCSGQRSEFDCVMALGQETADQAFADHWGSWITQDDINQMVQYGLNTIRIPVGYWLKEDLVYADSEHFPKGGIGYLEDVCGWASDAGMYIIIDLHGAPGAQQPKQPFTGQYAPNPGFYQDYQYDRALEFLEWMTTSIHQNNKFRNVGMLEIVNEPVQNADQASSMINSYYPSAFTRIRNTESSLGITSNNYLHIQMMNEKWGSGDPTQSLTDNYFAAYDDHRYVKWDSSVAVDKESYISASCVDDRGGNWPTIVGEWSLSVPDNVEHTADWEPSSNTDFYARWFAAQAIAYEKQEGWVFWSWKAQLGDYRWSYKDAVDAGVIPKDLDSIYDYSPC
Protein: F-box only protein 7 (F-box protein 7) (Q4V8X6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MKLRVRISRQTCRLELQGEEPSLAELRARVRESLLTRFGLRSDLDFRLSLNGKEDLLDTGQSLSSCGVVSGDLISVILPASSLEETQTSSAAAHQTHTDQQAGGSHVSSSSSVMEQHVQERVDQDLLERVDQQQECVDLQQDCMDQQQQQEQECVCAAAPPLLCCEAEDGLLPLALERLLDSSTCRSPSDCLMLALHLLLLETGFIPQGGAVSSGEMPIGWQAAGGVFRLQYVHPLLENSLVSVVAVPMGQTLVINAVLKMETSLENSRKLLLKPDEYVTAEWTGGSSGVVYRDLRRLSRLVRDQLVYPLMATARQALGLPLLFGLPVLPPELLLRLLRLLDVRSLVSLSAVCRHLNTATHDASLWRHLLHRDFRVSFPAGHQHRDTDWRELYKQKYRQRKEAARRGRHWFYPPPISPLIPFPSSPAPLPLYPPGIIGGDYDQMPVILPRPRFHPIGPLPGMSAPVGRRSLRPAGSGAADVRRAFI
Protein: SoxX (Q1W3E5)
Organism: Allochromatium vinosum (Chromatium vinosum)
Interaction partners:
Sequence:
MPLNVSHRSRLTALLFGLSALSSGSLPAADLPDDLALDGDAVAGREVATDRAKGNCVACHVMAGAESPGTIGPVLVSMQTRFPSKRDLAAQIWDATAKNPEAVMPPFGKHEILTRQEFVDVVEYIWSL
Protein: Tubulin alpha chain (Q6DC49)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Tight junction protein 1a
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
Sequence:
MRECISMHVGQAGAQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAIFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRTRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRKNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVADITNACFEPSNQMVKCDPRHGKYMACCLLYRGDVVPKDVNSAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGTDSMGEEDEEGEEY
Protein: Wiskott-Aldrich syndrome protein family member (WASP family protein member) (M9PCP4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367034}.
Interaction partners:
Sequence:
MPLPKRSIEPVHVARSVYQQDELQSVELETVTNTTLTNIIRQLSSLSKHAEDVFGELARDVGNIGDRANSLQARIDRLAIKVTQLDSTVEEVPLTDITRKKAFKSAKVFDQQIFSRATMPAPMMDTYAQCDKPPPLDKLNVYRDDGKDGLKFYTDPNYFFELWRQEMLKDTERVMHDKGKKLNRPRQDGGAGGAAGRGNKKQKTKIRVPHNTREQQRQRALVHGETLMPNNVIYRTPNSMVNEEAGYGNMGVYDTRPPRPNSIELNRSYQSEQIDGSTYEQLPPQMGNQYAATFGNGMGGPQQMHMQHQQMYDAGMYQSHALYGQTGQGVMSPEPIYGPGTPSRNKPRPSQPPPAPPSNGSGGGTPTASNANTPTRGRSMSTSRDALPPPPPVPDVISPMSGMNGVNSGHMAAKLLGRANSSSGAGSPNSVQNANDMVMTQLSNTFHSIGMTGNQLNSLSDLPPPPPVPDQHSPKMSPPNAAPPPPPPPPPVEEGMGSGNQHTLRPHQILPKSLANGEMQQPGQQNGVPHIVAPKKMLPPFHDPRNDLMKAIRDGITLRKVEKSEQKEIERNAAPLDVASILARRVAIELSESEDSDSEDDSEGWMEPNETSAXSLINSLKPDIILKNKKKK
Protein: Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin] (Q08431)
Organism: Homo sapiens (Human)
Function: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.
Subcellular location: Membrane {ECO:0000269|PubMed:19204935}; Peripheral membrane protein {ECO:0000269|PubMed:19204935}. Secreted {ECO:0000269|PubMed:19204935}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P79385}; Peripheral membrane protein {ECO:0000250|UniProtKB:P79385}. Note=Located in the acrosomal region of zona-pellucida bound sperm. {ECO:0000250|UniProtKB:P79385}.
Interaction partners:
- Integrin alpha-V
- Growth arrest-specific protein 6
- Integrin beta-5
- Lactotransferrin
- Pro-epidermal growth factor
- Tyrosine-protein kinase Mer
- Ubiquitin-like protein FUBI
- Intercellular adhesion molecule 1
- Butyrophilin subfamily 2 member A2
- Erythroid membrane-associated protein
Sequence:
MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC
Protein: Tubulin beta-3 chain (Beta-tubulin class-IV) (P09206)
Organism: Gallus gallus (Chicken)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a role in dorsal root ganglion axon projection towards the spinal cord.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Tubulin alpha chain
- Tubulin alpha-5 chain
- Gap junction alpha-1 protein
- Dynein heavy chain
- Tubulin alpha chain
- Tubulin alpha chain
- Tubulin alpha-2 chain
- Serine/threonine-protein kinase PLK
- Tubulin alpha chain
- Tubulin alpha chain
Sequence:
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFRQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPDLTQQMFDAKNMMAACEPGHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEAE
Protein: Brain mitochondrial carrier protein 1 (BMCP-1) (Mitochondrial uncoupling protein 5) (UCP 5) (Solute carrier family 25 member 14) (Q9Z2B2)
Organism: Mus musculus (Mouse)
Function: Participates in the mitochondrial proton leak measured in brain mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:11701769}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGIFPGIILIFLRVKFATAAVIVSGHQKSSTLSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDVRFKEIKYRGMFHALFRIYKEEGILALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLIVSGMLGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTLDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRLQI
Protein: Protein-serine/threonine kinase (EC 2.7.11.-) (D6RHG2)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|RuleBase:RU366032}.
Interaction partners:
Sequence:
MKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDP
Protein: Multiprotein-bridging factor 1c (Q9LV58)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators. Involved in the tolerance to heat and osmotic stress by partially activating the ethylene-response signal transduction pathway.
Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=PubMed:16283071 shows a localization restricted to the nucleus and not altered by heat or ABA treatment, while PubMed:18201973 describes a transport from the cytoplasm to the nucleus induced by heat stress.
Interaction partners:
- Heat stress transcription factor A-2
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Chaperone protein ClpB1
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Heat shock 70 kDa protein 4
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL38z/eL38y
- Alpha,alpha-trehalose-phosphate synthase 5
- Heat stress transcription factor B-2b
- Large ribosomal subunit protein eL42z/eL42y
Sequence:
MPSRYPGAVTQDWEPVVLHKSKQKSQDLRDPKAVNAALRNGVAVQTVKKFDAGSNKKGKSTAVPVINTKKLEEETEPAAMDRVKAEVRLMIQKARLEKKMSQADLAKQINERTQVVQEYENGKAVPNQAVLAKMEKVLGVKLRGKIGK
Protein: Vacuolar-sorting receptor 1 (AtVSR1) (BP80-like protein b) (AtBP80b) (Epidermal growth factor receptor-like protein 1) (AtELP) (AtELP1) (Spot 3 protein) (P93026)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Vacuolar-sorting receptor (VSR) involved in clathrin-coated vesicles sorting from Golgi apparatus to vacuoles. Required for the sorting of 12S globulin, 2S albumin and maybe other seed storage proteins to protein storage vacuoles (PSVs) in seeds. May also be implicated in targeting N-terminal propeptide containing proteins to lytic vacuoles.
Subcellular location: Membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass type I membrane protein. Prevacuolar compartment membrane; Single-pass type I membrane protein. Note=Associated to the Golgi apparatus, mostly on the trans-side, to clathrin-coated vesicles (CCVs) and to prevacuolar compartments (PVCs). May also be associated with the plasma membrane.
Interaction partners:
- Vesicle transport v-SNARE 11
- Vacuolar protein sorting-associated protein 45 homolog
- Receptor homology region, transmembrane domain- and RING domain-containing protein 1
- Protein KTI12 homolog
- Vacuolar protein sorting-associated protein 29
- Clathrin interactor EPSIN 1
- Syntaxin-21
- Thiol protease aleurain
- Elongator complex protein 3
- Elongator complex protein 2
Sequence:
MKLGLFTLSFLLILNLAMGRFVVEKNNLKVTSPDSIKGIYECAIGNFGVPQYGGTLVGTVVYPKSNQKACKSYSDFDISFKSKPGRLPTFVLIDRGDCYFTLKAWIAQQAGAAAILVADSKAEPLITMDTPEEDKSDADYLQNITIPSALITKTLGDSIKSALSGGDMVNMKLDWTESVPHPDERVEYELWTNSNDECGKKCDTQIEFLKNFKGAAQILEKGGHTQFTPHYITWYCPEAFTLSKQCKSQCINHGRYCAPDPEQDFTKGYDGKDVVVQNLRQACVYRVMNDTGKPWVWWDYVTDFAIRCPMKEKKYTKECADGIIKSLGIDLKKVDKCIGDPEADVENPVLKAEQESQIGKGSRGDVTILPTLVVNNRQYRGKLEKGAVLKAMCSGFQESTEPAICLTEDLETNECLENNGGCWQDKAANITACRDTFRGRLCECPTVQGVKFVGDGYTHCKASGALHCGINNGGCWRESRGGFTYSACVDDHSKDCKCPLGFKGDGVKNCEDVDECKEKTVCQCPECKCKNTWGSYECSCSNGLLYMREHDTCIGSGKVGTTKLSWSFLWILIIGVGVAGLSGYAVYKYRIRSYMDAEIRGIMAQYMPLESQPPNTSGHHMDI
Protein: Succinate dehydrogenase subunit (Q57X18)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRFPPAVGVSLRQLRLVASPAVVRNVPPVKSFAPFGAAATNEDVARAFNVPPALLENSCRPAECLFAKMDLARSRFAPLIATIGSEDVTKIAAEVRVAKMGKSVSTSAVAPPSRTIPPVAGAKEKFKTNVWKSVRELVTFYEEVMLPVRVKNEEFKFHELNNFHIKDDLKRGLSAFKQDYLDNQKVKLVEVQKQMEACQKFIRDIGASSFDTNIFNDIANILRICGERNPYALRLSLQVLEDMSLVGVPFDDITTKILNAAVFNDGPLDDSALLFTLLEYPERGEVSVATKPVEKIADETLEVISRRHRTPLDNGKLLRQSDTHPCLQRSPE
Protein: High mobility group B protein 2 (High mobility group protein B 1) (AtHMGbeta1) (HMG beta 1) (Nucleosome/chromatin assembly factor group D 02) (Nucleosome/chromatin assembly factor group D 2) (O49596)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds preferentially double-stranded DNA. Confers sensitivity to salt and drought stresses.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:20123078}. Cytoplasm, cytosol {ECO:0000269|PubMed:20123078}.
Interaction partners:
- Putative high mobility group B protein 11
- General transcription factor IIH subunit 2
- High mobility group B protein 12
- L-type lectin-domain containing receptor kinase I.9
- Actin-related protein 9
- RuvB-like protein 1
Sequence:
MKGAKSKTETRSSKLSVTKKPAKGAGRGKAAAKDPNKPKRPASAFFVFMEDFRETFKKENPKNKSVATVGKAAGDKWKSLSDSEKAPYVAKAEKRKVEYEKNIKAYNKKLEEGPKEDEESDKSVSEVNDEDDAEDGSEEEEDDD
Protein: Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] (P05164)
Organism: Homo sapiens (Human)
Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage.
Subcellular location: Lysosome.
Interaction partners:
- Azurocidin
- Myeloblastin
- Neutrophil elastase
- Cathepsin G
- Lactotransferrin
- Bactericidal permeability-increasing protein
- Cathelicidin antimicrobial peptide
- Matrix metalloproteinase-9
- Ceruloplasmin
- Cathepsin S
Sequence:
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS
Protein: Ubiquitin-conjugating enzyme E2 3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 3) (Ubiquitin carrier protein 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase 3) (P42746)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Interaction partners:
- E3 ubiquitin-protein ligase PRT6
- E3 ubiquitin-protein ligase BRE1-like 2
- E3 ubiquitin-protein ligase BRE1-like 1
- Ubiquitin-activating enzyme E1 2
- Ubiquitin-activating enzyme E1 1
- Ubiquitin-conjugating enzyme E2 1
- Ubiquitin-conjugating enzyme E2 2
- E3 ubiquitin-protein ligase UPL4
- Ubiquitin-ribosomal protein eS31x fusion protein
- Ubiquitin-ribosomal protein eS31y fusion protein
Sequence:
MTTPAKKRLMWDFKRLQKDPPVGISGAPQDNNIMHWNALIFGPEDTPWDGGTFKLTLHFTEDYPNKPPIVRFVSRMFHPNIYADGSICLDILQNQWSPIYDVAAVLTSIQSLLCDPNPDSPANAEAARLFSENKREYNRKVIEIVEQSYV
Protein: Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) (Q9BWW4)
Organism: Homo sapiens (Human)
Function: May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- LIM domain-binding protein 1
- Single-stranded DNA-binding protein 2
- LIM/homeobox protein Lhx1
- LIM domain-binding protein 2
- Insulin gene enhancer protein ISL-1
- Insulin gene enhancer protein ISL-2
- LIM domain transcription factor LMO4
- Single-stranded DNA-binding protein 4
- LIM/homeobox protein Lhx9
- LIM homeobox transcription factor 1-beta
Sequence:
MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFHDYSAAAAPSPVLGNIPPNDGMPGGPIPPGFFQGPPGSQPSPHAQPPPHNPSSMMGPHSQPFMSPRYAGGPRPPIRMGNQPPGGVPGTQPLLPNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQNYGSGMRPPPNSLGPAMPGINMGPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGPPGTPIMPSPADSTNSSDNIYTMINPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNGSLGSGDIDGLPKNSPNNISGISNPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV
Protein: Cytokine-inducible SH2-containing protein (Q08BW5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Cullin-5
- Cullin-5
- Erythropoietin receptor.
- Suppressor of cytokine signaling 9 isoform X1
- Uncharacterized protein.
- Elongin-B
- Suppressor of cytokine signaling 5
- Suppressor of cytokine signaling 5-like
Sequence:
MILCVEGPSPRALLPFSSPRRIDEPFLTIEDASKDYRALTLNFSYLDASGWYWGGISASEAHSVLKGASEGTFLIRDSSHPDYMLTLSVKTVRGPTNVRIEYRQCRFSLDSSSPARSHLQSFPDVHSLVQHYVGSKSEKNEEKMEEAHHVISSAPKECSVLLKLKKPIHCPQGFPSLKHLTRLVINKHTSSTEMLPLPNPLLYYLQNYPFQL
Protein: Microsomal triglyceride transfer protein large subunit (D4A1W8)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:P55157}. Golgi apparatus {ECO:0000250|UniProtKB:P55157}. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum. {ECO:0000250|UniProtKB:P55157}.
Interaction partners:
- Apolipoprotein B-100
- Protein disulfide-isomerase
- Diacylglycerol O-acyltransferase 1
- Apolipoprotein E
- Apolipoprotein A-II
- Sterol regulatory element-binding protein 1
- Hepatocyte nuclear factor 4-alpha
- Apolipoprotein C-III
- Apolipoprotein A-IV
- Fatty acid-binding protein, liver
Sequence:
MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGKLQDSVGYRISSDVDVVLLWRNPDGDDDQLIQVTITAVNVENAGQQRGEKSIFKGKSTPKIVGKDNLEALRRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLTSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVTSKATSVTTYKIEDSFVTAVVAEETRAFALNFLQTVAGKIVSKQKLELKTTEAGPRMVPGKQVAGVIKAIDSKYKAIPIVGQVLQSVCKGCPSLAEHWQSIRKHLEPENLSNAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPASLEAILDFLDFKSDSSIILQERFLYACGFASHPDEELLQALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDASFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNNPSYMDVKNILLSIGELPKEMNKYMLTIVQDILHFEMPASKMIRRVLKEMIVHNYDRFSKSGSSSAYTGYVERSPHAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMDIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDITVDSSFVKAGLESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVPGCELPLHQENSEMCNVVFPPQPESGNSGGGWF
Protein: Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (FK506-binding protein 5) (FKBP-5) (Rotamase) (Q64378)
Organism: Mus musculus (Mouse)
Function: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11751894}. Nucleus {ECO:0000269|PubMed:11751894}.
Interaction partners:
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- Glucocorticoid receptor
- Heat shock 70 kDa protein 1B
- PH domain leucine-rich repeat-containing protein phosphatase 1
- Prostaglandin E synthase 3
- Peptidyl-prolyl cis-trans isomerase FKBP4
- Progesterone receptor
- DnaJ homolog subfamily B member 1
- RAC-alpha serine/threonine-protein kinase
Sequence:
MTTDEGTSNNGENPAATMTEQGEDITTKKDRGVLKIVKRVGTSDEAPMFGDKVYVHYKGMLSDGKKFDSSHDRKKPFAFSLGQGQVIKAWDIGVSTMKKGEICHLLCKPEYAYGSAGHLQKIPSNATLFFEIELLDFKGEDLFEDSGVIRRIKRKGEGYSNPNEGATVKVHLEGCCGGRTFDCRDVVFVVGEGEDHDIPIGIDKALVKMQREEQCILYLGPRYGFGEAGKPKFGIDPNAELMYEVTLKSFEKAKESWEMDTKEKLTQAAIVKEKGTVYFKGGKYTQAVIQYRKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYNKAVECCDKALGLDSANEKGLYRRGEAQLLMNDFESAKGDFEKVLAVNPQNRAARLQISMCQRKAKEHNERDRRVYANMFKKFAERDAKEEASKAGSKKAVEGAAGKQHESQAMEEGKAKGHV
Protein: Regulator of G protein Signaling 21 variant 2 (A0A5S9EHU3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPVKSPTTETLAWSENMDSLLANQAGLDAFRTFLKSEYSEENVEFWLACEDFKKTECREKIATKAKTIYSEFIVADAPKEINIDFSTRDLISRNIAEPTPKCFDEAQKLIYSLMAKDSFPRFLKSEIYKKLVNSQQVGNHKRWLPFL
Protein: Bowman-Birk type proteinase inhibitor A6 (HOSPI-A6) (C0HLS7)
Organism: Hyacinthus orientalis (Common hyacinth)
Function: Serine protease inhibitor. Strongly inhibits trypsin (Ki = 4 nM) and elastase (Ki = 4.8 nM). Also inhibits chymotrypsin with a Ki of 22 nM. Does not inhibit bacterial subtilisin.
Interaction partners:
Sequence:
WPPVEDRPCCERCTACTLMLPDEANTCVCGDIVPKCHQGCSLCERVDTPSGYQCKSFEYYNCGTKCP
Protein: Gonadotropin I beta subunit (Q9W6Q8)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU004069}.
Interaction partners:
Sequence:
VMAMLWVTPVRAGTDCRYGCRLNSMTITVEREDCHGSITITTCAGLCETTDMNYQSTWLPRSQGACNFKDWSYEKVYLEGCPSGVDPFFIPVAKSCDCIKCETDNTDCDRISMATPSCIVNPL