wanglab/gogpt-training-data huggingface dataset:
Protein: Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (mMad3) (SMAD family member 3) (SMAD 3) (Smad3) (Q8BUN5)
Organism: Mus musculus (Mouse)
Function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:22781750}. Nucleus {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:22781750}. Note=Cytoplasmic and nuclear in the absence of TGF-beta (PubMed:21145499). On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:21145499). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (By similarity). Co-localizes with LEMD3 at the nucleus inner membrane (By similarity). MAPK-mediated phosphorylation appears to have no effect on nuclear import. PDPK1 prevents its nuclear translocation in response to TGF-beta (By similarity). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (PubMed:21145499). {ECO:0000250|UniProtKB:P84022, ECO:0000269|PubMed:21145499}.
Interaction partners:
- Mothers against decapentaplegic homolog 4
- TGF-beta receptor type-1
- Mothers against decapentaplegic homolog 2
- Transcription factor E2F4
- Zinc finger FYVE domain-containing protein
- E3 ubiquitin-protein ligase TRIM33
- Forkhead box protein H1
- Zinc finger protein SNAI1
- TGF-beta receptor type-2
- Histone lysine acetyltransferase CREBBP
Sequence:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
Protein: Homeobox protein EMX2 (Empty spiracles homolog 2) (Empty spiracles-like protein 2) (Q04744)
Organism: Mus musculus (Mouse)
Function: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
Subcellular location: Nucleus {ECO:0000269|PubMed:15247416}. Cell projection, axon {ECO:0000269|PubMed:15247416}. Note=Detected in axons within the olfactory mucosa and glomeruli in the olfactory bulb. {ECO:0000269|PubMed:15247416}.
Interaction partners:
- Forkhead box protein G1
- Transcription factor Sp8
Sequence:
MFQPAPKRCFTIESLVAKDSPLPASRSEDPIRPAALSYANSSPINPFLNGFHSAAAAAAAGRGVYSNPDLVFAEAVSHPPNPAVPVHPVPPPHALAAHPLPSSHSPHPLFASQQRDPSTFYPWLIHRYRYLGHRFQGNDTSPESFLLHNALARKPKRIRTAFSPSQLLRLEHAFEKNHYVVGAERKQLAHSLSLTETQVKVWFQNRRTKFKRQKLEEEGSDSQQKKKGTHHINRWRIATKQASPEEIDVTSDD
Protein: Major sperm protein (Q22622)
Organism: Caenorhabditis elegans
Interaction partners:
- Serpentine Receptor, class D
Sequence:
MSKATSACSQKKTSLLDPSPKKSSVIETTTKKTSGIESKLLPNELPSTGTTGTSGVKNGASSPKTSPAKTTTTTTTVVTQKVSNQPTAPISTLPPRKPTAQKSRELSPPKAKKSPSPSRTGSGDSGSRKESSASRKDSSKTEKLVKDLENVKLEKGDSRESATLPTPKQYPASDDEEDTKERKSLRFGTTTEWQSDNLEEFYREHEKFPNAEAVKKFGQMYSMTELIAETWLETRRQQTYQKYVEKGLQTDPSVIQFYCESLKIAEGLRLENPSIQTKSFFSLNGVNALEQKKEEEEKMQPVISVSSNKVFISPKKEQKCQLTIKNDGEVNVVYQISIMNAANYVMSPICAILLPKEELTLNITRKPGKLLEEEFFRIDYGVAPEGIIDARDSSDRAEFTNREIIEVVEIDEKEMKIVR
Protein: Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] (P22985)
Organism: Rattus norvegicus (Rat)
Function: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
Subcellular location: Peroxisome {ECO:0000269|PubMed:11993848}. Cytoplasm {ECO:0000269|PubMed:11993848}. Secreted {ECO:0000250}.
Interaction partners:
- Butyrophilin, subfamily 1, member A1
- Purine nucleoside phosphorylase
- Uricase
- Guanine deaminase
- Thiopurine S-methyltransferase
- Hypoxanthine-guanine phosphoribosyltransferase
- Cytochrome P450 1A2
- Arylamine N-acetyltransferase 2
- Butyrophilin-like 9
- arylamine N-acetyltransferase
Sequence:
MTADELVFFVNGKKVVEKNADPETTLLVYLRRKLGLCGTKLGCGEGGCGACTVMISKYDRLQNKIVHFSVNACLAPICSLHHVAVTTVEGIGNTQKLHPVQERIARSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGSGNNPNCCMNQTKDQTVSLSPSLFNPEDFKPLDPTQEPIFPPELLRLKDTPQKKLRFEGERVTWIQASTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPLIVCPAWIPELNSVVHGPEGISFGASCPLSLVESVLAEEIAKLPEQKTEVFRGVMEQLRWFAGKQVKSVASIGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVRMDHTFFPGYRKTLLRPEEILLSIEIPYSKEGEFFSAFKQASRREDDIAKVTSGMRVLFKPGTIEVQELSLCFGGMADRTISALKTTPKQLSKSWNEELLQSVCAGLAEELQLAPDAPGGMVEFRRTLTLSFFFKFYLTVLQKLGRADLEDMCGKLDPTFASATLLFQKDPPANVQLFQEVPKDQSEEDMVGRPLPHLAANMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKITSIDTSEAKKVPGFVCFLTAEDVPNSNATGLFNDETVFAKDEVTCVGHIIGAVVADTPEHAQRAARGVKITYEDLPAIITIQDAINNNSFYGSEIKIEKGDLKKGFSEADNVVSGELYIGGQEHFYLETNCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPDNRIVVRVKRMGGGFGGKETRSTVVSTALALAAHKTGRPVRCMLDRDEDMLITGGRHPFLAKYKVGFMKTGTVVALEVAHFSNGGNTEDLSRSIMERALFHMDNAYKIPNIRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSEVAITCGLPAEEVRRKNMYKEGDLTHFNQKLEGFTLPRCWDECIASSQYLARKREVEKFNRENCWKKRGLCIIPTKFGISFTLPFLNQGGALVHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHISETSTNTVPNTSPTAASASADLNGQGVYEACQTILKRLEPFKKKKPTGPWEAWVMDAYTSAVSLSATGFYKTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTMEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKRAIYASKAVGEPPLFLASSIFFAIKDAIRAARAQHGDNAKQLFQLDSPATPEKIRNACVDQFTTLCVTGVPENCKSWSVRI
Protein: Numa1 protein (Q4G051)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
KYVQELAAVRTDAETHLAEMRQEAQSTSRELEVMTAKYESAKVKVLEERQRFQEERQKLTAQVEQLEVFHREQTKQVEELNKKLTESEQASRVQQQKLKAFQAQGGESQQEVQCLQTQLSELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELREQLQDLEQLQKDNKELRSETERLGRELQQAGLKTKEAEQACRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQVKPQLDLSIDSLDLSLEEGTPCSVASKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARGQAPLETSLDSLGDAFPDSGRKTRSARRRTTQIINITMTKKLELEEPDSANSSFYSTQSAPASQANLRATSSTQSLARLGSPDDSNSALLSLPGYRPTTRSSARRSQTRTSSGAPHGRNSFYMGTCQDEPEQVDDWNRIAELQQRNRVCPPHLKTCYPLESRPALSLATITDEEMKTGDPRETLRRASMQPAQIAEGAGITTRQQRKRVSSETHQGPGTPESKKATSCFPRPMTPRDRHEGRKQNSTADAQKKAAPVLKQSDRRQSMAFSILNTPKKLGNSLLRRGTSKKTPAKVSPNPRSGTRRSPRIATTTAGAATAATTPRAKGKAKH
Protein: Stathmin-1 (Q9GQR6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVNNTVDTEATEIRCQEKSRGGLSYEVILAEPAPNVAVPKRPVTPGKNVSVEEIEQKLKAAEERRISLEAKKMADISTKLAKVEEATRKKDEITNEFITQTKEQLESKMELHVEKREAIISDMKEKLKIHAQDIEKTRETLEQQKANEQKAIEEKLKIAQSLRDENIKKMLDRLKEHNTIKIAEIKSQNDQLECQKIEEKARIYENKLFAAEQKREKELQKKLKKFKNSNVAPS
Protein: Costunolide synthase (LsCOS) (EC 1.14.14.150) (Cytochrome P450 71BL2) (F8S1I0)
Organism: Lactuca sativa (Garden lettuce)
Function: Involved in the biosynthesis of germacrene-derived sesquiterpene lactones. Component of the parthenolide biosynthetic pathway; parthenolide and conjugates are promising anti-cancer drugs highly active against colon cancer cells. Hydroxylates germacrene A acid to 6-alpha-hydroxy-germacrne A acid, a precursor of sesquiterpene lactones that spontaneously undergoes a lactonization which yields costunolide.
Subcellular location: Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEPLTIVSLAVASFLLFAFWALSPKTSKNLPPGPPKLPIIGNIHQLKSPTPHRVLRNLAKKYGPIMHLQLGQVSTVVVSTPRLAREIMKTNDISFADRPTTTTSQIFFYKAQDIGWAPYGEYWRQMKKICTLELLSAKKVRSFSSIREEELRRISKVLESKAGTPVNFTEMTVEMVNNVICKATLGDSCKDQATLIEVLYDVLKTLSAFNLASYYPGLQFLNVILGKKAKWLKMQKQLDDILEDVLKEHRSKGRNKSDQEDLVDVLLRVKDTGGLDFTVTDEHVKAVVLDMLTAGTDTSSATLEWAMTELMRNPHMMKRAQEEVRSVVKGDTITETDLQSLHYLKLIVKETLRLHAPTPLLVPRECRQACNVDGYDIPAKTKILVNAWACGTDPDSWKDAESFIPERFENCPINYMGADFEFIPFGAGRRICPGLTFGLSMVEYPLANFLYHFDWKLPNGLKPHELDITEITGISTSLKHQLKIVPILKS
Protein: GDP-mannose 4,6-dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (Q72EX0)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- GDP-L-fucose synthase
- mannose-1-phosphate guanylyltransferase
- Large ribosomal subunit protein uL4
- Exopolysaccharide biosynthesis protein, putative
- Exopolysaccharide biosynthesis protein, putative
Sequence:
MKRALITGITGQDGAYLAEFLLAKGYEVHGIKRRASLFNTDRIDHLYQDPHEKRRRFILHYGDMTDASNLIRIVQEVQPDEVYNLAAQSHVKVSFELPEYTANVDALGPLRLLEAIRILGLEKSTRFYQASTSELFGLVQEVPQTERTPFYPRSPYACAKLYAYWIAVNYREAYGMYACNGILFNHESPVRGETFVTRKITRALARTVLGLTNGLHLGNLNALRDWGHARDYVEMQWLMLQQDKPEDFVIATGHQYSVRDFVATAAGELGLALEWHGEGVDEKGVVTSVDAKALERLTGAAGASCPVKPGDVLVQVDPRYFRPTEVETLLGDPTRAHERLGWKPRTTFADMVAEMVREDVNLARRDAVCKVAGFRAFSYNE
Protein: Ecdysone-induced protein 75B, isoform B (E75-C) (Nuclear receptor subfamily 1 group D member 3, isoform B) (P13055)
Organism: Drosophila melanogaster (Fruit fly)
Function: Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Taiman, isoform G
- Ecdysone receptor
- Smrter, isoform G
- Protein ultraspiracle
- Ecdysone-induced protein 74EF isoform B
- Nuclear hormone receptor HR96
- GH23983p
- Probable nuclear hormone receptor HR3
- Hormone receptor 51
- Mediator of RNA polymerase II transcription subunit 1
Sequence:
MEAVQAAAAATSSGGSSGSVPGSGSGSASKLIKTEPIDFEMLHLEENERQQDIEREPSSSNSNSNSNSLTPQRYTHVQVQTVPPRQPTGLTTPGGTQKVILTPRVEYVQQRATSSTGGGMKHVYSQQQGTAASRSAPPETTALLTTTSGTPQIIITRTLPSNQHLSRRHSASPSALHHYQQQQPQRQQSPPPLHHQQQQQQQHVRVIRDGRLYDEATVVVAARRHSVSPPPLHHHSRSAPVSPVIARRGGAAAYMDQQYQQRQTPPLAPPPPPPPPPPPPPPPQQQQQQYISTGVPPPTAAARKFVVSTSTRHVNVIASNHFQQQQQQHQAQQHQQQHQQHQQHQQHVIASVSSSSSSSAIGSGGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPPPPPPPKVKHASSSSSGNSSSSNTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTEHKELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALASSAPLLAATLSGGCPLRNRANSGSSGDSGAAEMDIVGSHAHLTQNGLTITPIVRHQQQQQQQQQIGILNNAHSRNLNGGHAMCQQQQQHPQLHHHLTAGAARYRKLDSPTDSGIESGNEKNECKAVSSGGSSSCSSPRSSVDDALDCSDAAANHNQVVQHPQLSVVSVSPVRSPQPSTSSHLKRQIVEDMPVLKRVLQAPPLYDTNSLMDEAYKPHKKFRALRHREFETAEADASSSTSGSNSLSAGSPRQSPVPNSVATPPPSAASAAAGNPAQSQLHMHLTRSSPKASMASSHSVLAKSLMAEPRMTPEQMKRSDIIQNYLKRENSTAASSTTNGVGNRSPSSSSTPPPSAVQNQQRWGSSSVITTTCQQRQQSVSPHSNGSSSSSSSSSSSSSSSSSTSSNCSSSSASSCQYFQSPHSTSNGTSAPASSSSGSNSATPLLELQVDIADSAQPLNLSKKSPTPPPSKLHALVAAANAVQRYPTLSADVTVTASNGGPPSAAASPAPSSSPPASVGSPNPGLSAAVHKVMLEA
Protein: Rho guanine nucleotide exchange factor (GEF) 5 (A0A090N7S2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGGFSRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESYLQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPREELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQA
Protein: Transcriptional regulator, PpsR (Q3J179)
Organism: Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides)
Interaction partners:
- AppA, antirepressor of ppsR, sensor of blue light
- Regulatory protein, PpaA
- Reaction center protein H chain
- 2-vinyl bacteriochlorophyllide hydratase
- tRNA-dihydrouridine synthase
- tRNA-dihydrouridine
- Light-harvesting 1
- Light-independent protochlorophyllide reductase subunit N
- Bacteriochlorophyll synthase 33 kDa chain
- Geranylgeranyl diphosphate reductase
Sequence:
MLAGGSLPSLAPDLVRDLIATAADISLLVSQEGVVREVMANPHHPSFGQLSEWEGRPLEEVLTAESVAKFRLRSEGLEPGRGSVAVELNHIDPRSFEFPIRYILHRLPADRSILMLGRDLRPIAEVQQQLVAAQLAMERDYETQREMETRYRVVLDVSRDPMVLVSMSTGRIVDLNSAAGLLLGGVRQDLLGAAIAQEFEGRRRGEFMETMTNLAATESAAPVEVLARRSQKRLLVVPRVFRAAGERLLLCQIDPADATQPVGDELSENLARLYHEGVDGIVFSDADGTIRGANEAFLNMTDSSSLAAIRGRSIADFLARGSVDLRVLIDSVRRTGQLRLYATRLTTDFAGQIAAEISATWLDDRERPLLVLVVRDTSRADTMRRPVPATGVIDEPARNVMELVGNSTLKDIVAETTDVVEKMCIETALELTRNNRVAAAEMLSLSRQSLYVKLRKFGLLNKDE
Protein: Zinc finger protein 606 (Zinc finger protein 328) (Q8WXB4)
Organism: Homo sapiens (Human)
Function: May act as a transcriptional repressor.
Subcellular location: Nucleus {ECO:0000269|PubMed:15964554}.
Interaction partners:
Sequence:
MAAINPWASWGALTDQSWGMTAVDPWASWALCPQYPAWHVEGSLEEGRRATGLPAAQVQEPVTFKDVAVDFTQEEWGQLDLVQRTLYRDVMLETYGHLLSVGNQIAKPEVISLLEQGEEPWSVEQACPQRTCPEWVRNLESKALIPAQSIFEEEQSHGMKLERYIWDDPWFSRLEVLGCKDQLEMYHMNQSTAMRQMVFMQKQVLSQRSSEFCGLGAEFSQNLNFVPSQRVSQIEHFYKPDTHAQSWRCDSAIMYADKVTCENNDYDKTVYQSIQPIYPARIQTGDNLFKCTDAVKSFNHIIHFGDHKGIHTGEKLYEYKECHQIFNQSPSFNEHPRLHVGENQYNYKEYENIFYFSSFMEHQKIGTVEKAYKYNEWEKVFGYDSFLTQHTSTYTAEKPYDYNECGTSFIWSSYLIQHKKTHTGEKPYECDKCGKVFRNRSALTKHERTHTGIKPYECNKCGKAFSWNSHLIVHKRIHTGEKPYVCNECGKSFNWNSHLIGHQRTHTGEKPFECTECGKSFSWSSHLIAHMRMHTGEKPFKCDECEKAFRDYSALSKHERTHSGAKPYKCTECGKSFSWSSHLIAHQRTHTGEKPYNCQECGKAFRERSALTKHEIIHSGIKPYECNKCGKSCSQMAHLVRHQRTHTGEKPYECNKCGKSFSQSCHLVAHRRIHTGEKPYKCNQCERSFNCSSHLIAHRRTHTGEKPYRCNECGKAFNESSSLIVHLRNHTGEKPYKCNHCEKAFCKNSSLIIHQRMHSGEKRFICSECGKAFSGHSALLQHQRNHSEEKLN
Protein: Elongator complex protein 3 (AtELP3) (EC 2.3.1.311) (Elongator component 3) (Protein ELONGATA 3) (Protein ENHANCER-OF-ASYMMETRIC-LEAVES-TWO1) (tRNA uridine(34) acetyltransferase) (Q93ZR1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Promotes organ development by modulating cell division rate. Required for auxin distribution or signaling. Required for meristem cell cycle activation at the time of germination. Mediates the establishment of leaf polarity independently of AS2 and the ta-siRNA-related pathway. Indirectly involved in negatively regulating the expression of genes that participate in UV-B responses, such as DNA repair enzymes and enzymes that participate in sunscreen pigment biosynthesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:20080602, ECO:0000269|PubMed:22026817, ECO:0000269|PubMed:22404109}. Cytoplasm {ECO:0000269|PubMed:22404109}. Note=Localized in euchromatin during interphase. {ECO:0000269|PubMed:20080602}.
Interaction partners:
- Elongator complex protein 2
- Elongator complex protein 4
- Elongator complex protein 1
- Protein KTI12 homolog
- Elongator complex protein 6
- Elongator complex protein 5
- Histone acetyltransferase GCN5
- Histone acetyltransferase of the MYST family 1
- Histone acetyltransferase of the MYST family 2
- Vacuolar-sorting receptor 1
Sequence:
MATAVVMNGELKKQPRPGKGGYQGRGLTEEEARVRAISEIVSTMIERSHRNENVDLNAIKTAACRKYGLARAPKLVEMIAALPDSERETLLPKLRAKPVRTASGIAVVAVMSKPHRCPHIATTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYNPYVQARSRIDQLKRLGHSVDKVEFILMGGTFMSLPAEYRDFFIRNLHDALSGHTSANVEEAVAYSEHSATKCIGMTIETRPDYCLGPHLRQMLIYGCTRLEIGVQSTYEDVARDTNRGHTVAAVADCFCLAKDAGFKVVAHMMPDLPNVGVERDMESFKEFFESPSFRADGLKIYPTLVIRGTGLYELWKTGRYRNYPPEQLVDIVARILSMVPPWTRVYRVQRDIPMPLVTSGVEKGNLRELALARMDDLGLKCRDVRTREAGIQDIHHKIKPEQVELVRRDYTANEGWETFLSYEDTRQDILVGLLRLRKCGKNVTCPELMGKCSVVRELHVYGTAVPVHGRDADKLQHQGYGTLLMEEAERIARREHRSNKIGVISGVGTRHYYRKLGYELEGPYMVKHLL
Protein: Ras-related GTP-binding protein B (Rag B) (RagB) (EC 3.6.5.-) (Q63487)
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q5VZM2}. Lysosome membrane {ECO:0000250|UniProtKB:Q5VZM2}. Note=Recruited to the lysosome surface by the Ragulator complex. {ECO:0000250|UniProtKB:Q5VZM2}.
Interaction partners:
- Ras-related GTP-binding protein
- Ras-related GTP-binding protein
- Serine/threonine-protein kinase mTOR
- NPR2-like, GATOR1 complex subunit
- DEP domain containing 5, GATOR1 subcomplex subunit
- Folliculin
- GATOR complex protein NPRL3
- Regulatory-associated protein of mTOR
- Folliculin interacting protein 2
- Folliculin interacting protein 1
Sequence:
MEESDSEKKTEKENVGPKVEPPLGEPEGSLGWAMPNAAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPEAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKQCLLMR
Protein: Cruzioseptin-1 (CZS-1) (A0A193H395)
Organism: Cruziohyla calcarifer (Splendid leaf frog) (Agalychnis calcarifer)
Function: Has antimicrobial activity against Gram-negative bacterium E.coli (MIC=15.11 uM), aginst Gram-positive bacterium S.aureus (MIC=3.77 uM) and against fungus C.albicans (MIC=3.77 uM). At higher concentrations also has a bactericidal and fungicidal effect. Has hemagglutinating activity against horse erythrocytes.
Subcellular location: Secreted {ECO:0000269|PubMed:27321580}.
Interaction partners:
Sequence:
MAFLKKSLFLVLFLGLVSLSICEEEKREENEEEQDDDEQSEEKRGFLDIVKGVGKVALGAVSKLFGQEER
Protein: Uncharacterized calcium-binding protein C1687.14c (O94455)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- UV excision repair protein rhp23
- DNA repair protein rhp41
Sequence:
MSVSTKRLEMDEEAEEAFDLFDVTHKGYIDFEDLRRSCAQLGENLTKEQLQLMLDLAGTNGKVSREEFAELWIHIS
Protein: SH3GL2 protein (Q8IZ09)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKERQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSH
Protein: Dystrophin-related protein 2 (DRP-2) (Q05AA6)
Organism: Mus musculus (Mouse)
Function: Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.
Subcellular location: Postsynaptic density {ECO:0000250|UniProtKB:Q9EPA0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9EPA0}. Perikaryon {ECO:0000250|UniProtKB:Q9EPA0}. Cell membrane {ECO:0000269|PubMed:11430802, ECO:0000269|PubMed:22764250, ECO:0000269|PubMed:23152929}; Peripheral membrane protein {ECO:0000269|PubMed:22764250}. Note=Detected in Schwann cells at periaxonal myelin membranes. {ECO:0000269|PubMed:22764250}.
Interaction partners:
- Periaxin
- Dystroglycan 1
Sequence:
MQPLVMQGCPYTLPRCHEWHAADRFHHSSSLRNTCPQPQVRAAVTIPAPPWDGAGDPCLSPKLLNGTVGATGPLEPSAMNLCWNEIKKKSHNLRARLEAFSDLSGKLQLPLREIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSKGPYISSVLESAQAFLSQHPFEELEESQSESKDTSPRQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIEHTLEHLLEIQGAMEELSSTLTQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPVKDGVKLVNDLAHQLAISDVHLSMENSRALEQINIRWKQLQVSVAERLKQLQDAHRDFGPGSQHFLSTSVQVPWERAISPNKVPYYINHQAQTTCWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQASEHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKTGIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGALLHEAIQVPRQLGEVAAFGGSNVEPSVRSCFRFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQCPIKGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFRSKQYFSKHPQRGYLPVQSVLESDCSETPASSPMLPHADTHSRIEHFASRLAEMESQNCSFFNDSLSPDDSIDEDQYLLRHSSPITDREPAFGQQAPCSMATESKGELEKILAHLEDENRILQGELRRLKWQHEEAAEAPTLVEGSAEATPDHRNEELLAEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPSESDGNGSAGSSLASSPRQSEGSHPREKGQTTPDTEVADDVGSKSQDVSLCLEDIMEKLRHAFPSVRSSDVTANTLLAS
Protein: IP14417p1 (Testis-specifically expressed bromodomain containing protein-1, isoform A) (Testis-specifically expressed bromodomain containing protein-1, isoform B) (Q9VCG6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Transcription initiation factor TFIID subunit 8
- Protein mitoshell
- IP14655p
- Uncharacterized protein
- Gustatory receptor-like 36a
- Tenecin-3-like
- BPTI/Kunitz inhibitor domain-containing protein
- CG42827-PC, CG42827-PD
- Carbonic anhydrase
- Transcription initiation factor TFIID subunit 7
Sequence:
MNELQSNSNQPPPRNEPYLQPVNGIVQPPVIPPPNRPGRRTNILEELKSVLNCLWRNRFSYHFRHPVDSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGKLLMEAFYMRMESIDLSTEVELKPKSEKRKRKATESLDQASTSFSAPRASNNYSRQWLSSSSSWLCPPPMPGGVSSFNPSFRNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIFKNNWETNEAMDPPPSEPISYRPLDSLAAPLPSPPMEPMTLPWPTPAPVESPASSPPPAPNPPIIICYKSLDRMIEKSHSDHLLKSMVKRKRKQVTWAFNQADYWRRYSQNPDYDHDREEKLDWKILQERLDSDNFESFDGFVSSVRKMFQNALRCFPEDGLVKVSVKKTNEIFEKRLPKYRELIATAKEKGRQLVASREQDFRDSQNLLIKQENANKNFKGWVPKPFIIKTESLFVQEQRVYKMEPQDVQEFSPGTEPLDDQTYDSD
Protein: RNA helicase (EC 3.6.4.13) (D3ZD97)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Splicing factor 45
- Small nuclear ribonucleoprotein polypeptide A'
- Tuftelin-interacting protein 11
- Something about silencing protein 10
- 116 kDa U5 small nuclear ribonucleoprotein component
- Small nuclear ribonucleoprotein F
- Nucleolar protein 58
- PIN2/TERF1-interacting telomerase inhibitor 1
- Cell division cycle 5-like protein
- Pre-mRNA-processing-splicing factor 8
Sequence:
MSKRHRLDLGEDYPSGKKRAGTDGKDRERDRDREDRSKDRDRERDRGDREREREKEKEKELRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHTGHAGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQLDRIIAKLQSKEYSQY