wanglab/gogpt-training-data huggingface dataset:
Protein: C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369) (Q9BXN2)
Organism: Homo sapiens (Human)
Function: Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:16870151, ECO:0000269|PubMed:17182550, ECO:0000269|PubMed:17230442}; Single-pass type II membrane protein {ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:16870151, ECO:0000269|PubMed:17230442}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000305}.
Interaction partners:
- Tyrosine-protein kinase SYK
- Toll-like receptor 2
- Galectin-3
- Low affinity immunoglobulin gamma Fc region receptor II-b
- Galectin-9
- Galectin-9B
- Galectin-9C
- Toll-like receptor 4
- Caspase recruitment domain-containing protein 9
- Leukocyte antigen CD37
Sequence:
MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWRLIAVILGILCLVILVIAVVLGTMAIWRSNSGSNTLENGYFLSRNKENHSQPTQSSLEDSVTPTKAVKTTGVLSSPCPPNWIIYEKSCYLFSMSLNSWDGSKRQCWQLGSNLLKIDSSNELGFIVKQVSSQPDNSFWIGLSRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVSVIYDQLCSVPSYSICEKKFSM
Protein: Histone H2A.Z-specific chaperone CHZ1 (Q6FWW0)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Histone H2A
- Histone chaperone ASF1
- FK506-binding protein 4
- FK506-binding protein 3
- FACT complex subunit SPT16
Sequence:
MSEEKEVKPVVAENAEVPAKVEKKKRRRRNYDDYDAEVTESEKKKSKPSEASGKAGAAAAGDSDSESDIDDAKLDRLESNEDEEEDDLAEIDTSNIITTGRRTRGKIIDYKKTAKELDASEQKTDSAATEAAPGAADDEEDDDADFKE
Protein: Proteasome subunit alpha type-7 (Proteasome component DD5) (P34120)
Organism: Dictyostelium discoideum (Social amoeba)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-3
- Proteasome subunit beta type-5
- Proteasome subunit beta type-7
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-4
- Proteasome subunit beta type-2
- Proteasome subunit beta type-6
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-4
Sequence:
MSSARYDRAITVFSPDGHLFQVEYAMEAVRKGTVAVGVRGKDVIVLGVEKKATAKLQDARSIRKIVKLDDHICLTFAGLTADSRVLISKALMECQSYRLTVEDSPSVEYISKFIAGIQQRYTQSGGVRPFGISTLIVGFDTDGTPNLYQTDPSGSYSSWKAAAIGRSSKSVGEFLEKNYTDVSEEESIKLAVRALLEIVESGNKNIEIAVIRNKQPIVLLDEQEIDKLVAVVEAEKEIQKEQEKSEKQQK
Protein: ISWI chromatin-remodeling complex ATPase CHR11 (EC 3.6.4.-) (ISW2-like) (Protein CHROMATIN REMODELING 11) (Sucrose nonfermenting protein 2 homolog) (Q8RWY3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses intrinsic ATP-dependent nucleosome-remodeling activity. Constitutes the catalytic subunit of several complexes capable of forming ordered nucleosome arrays on chromatin (By similarity). Involved in the formation of nucleosome distribution patterns. Involved in nuclear proliferation during megagametogenesis and cell expansion in the sporophyte. Required for the maintenance of the plant vegetative phase. In association with RLT1 or RLT2 may prevent the early activation of the vegetative-to-reproductive transition by regulating key genes that contribute to flower timing, such as FT, SEP1, SEP3, AGL8/FUL, SOC1 and FLC. Necessary to acquire heat stress (HS) memory.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:22694359}.
Interaction partners:
- Homeobox-DDT domain protein RLT1
- Histone H4
- Protein FORGETTER 1
- DDT domain-containing protein
- Probable F-box protein At4g22060
- DNA polymerase II subunit B4
- Chromatin structure-remodeling complex protein SYD
- Homeobox-DDT domain protein RLT2
- Protein CHROMATIN REMODELING 20
- Methyl-CpG-binding domain-containing protein 9
Sequence:
MARNSNSDEAFSSEEEEERVKDNEEEDEEELEAVARSSGSDDDEVAAADESPVSDGEAAPVEDDYEDEEDEEKAEISKREKARLKEMQKLKKQKIQEMLESQNASIDADMNNKGKGRLKYLLQQTELFAHFAKSDGSSSQKKAKGRGRHASKITEEEEDEEYLKEEEDGLTGSGNTRLLTQPSCIQGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLAYLHEYRGINGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFLGNPEERRHIREDLLVAGKFDICVTSFEMAIKEKTALRRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLEAVNAGGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPYTTGDHLITNAGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYLYCRIDGNTGGDERDASIEAYNKPGSEKFVFLLSTRAGGLGINLATADVVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTESAIEEKVIERAYKKLALDALVIQQGRLAEQKTVNKDELLQMVRYGAEMVFSSKDSTITDEDIDRIIAKGEEATAELDAKMKKFTEDAIQFKMDDSADFYDFDDDNKDENKLDFKKIVSDNWNDPPKRERKRNYSESEYFKQTLRQGAPAKPKEPRIPRMPQLHDFQFFNIQRLTELYEKEVRYLMQTHQKNQLKDTIDVEEPEEGGDPLTTEEVEEKEGLLEEGFSTWSRRDFNTFLRACEKYGRNDIKSIASEMEGKTEEEVERYAKVFKERYKELNDYDRIIKNIERGEARISRKDEIMKAIGKKLDRYRNPWLELKIQYGQNKGKLYNEECDRFMICMIHKLGYGNWDELKAAFRTSSVFRFDWFVKSRTSQELARRCDTLIRLIEKENQEFDERERQARKEKKLAKSATPSKRPLGRQASESPSSTKKRKHLSMR
Protein: Synaptotagmin-2 (Inositol polyphosphate-binding protein) (IP4-binding protein) (IP4BP) (Synaptotagmin II) (SytII) (P46097)
Organism: Mus musculus (Mouse)
Function: Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P29101}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P29101}. Cytoplasm {ECO:0000250|UniProtKB:P29101}.
Interaction partners:
- Synaptosomal-associated protein 25
- Vesicle-associated membrane protein 2
- Stonin-2
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 1
- Synaptic vesicle glycoprotein 2A
- Complexin-1
- Synapsin-1
- Syntaxin-1A
- Synaptotagmin-1
Sequence:
MRNIFKRNQEPNVAPATTTATMPLAPVAPADNSTESTGPGESQEDMFAKLKEKFFNEINKIPLPPWALIAMAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELAGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK
Protein: Epididymis luminal protein 177 (Epididymis secretory sperm binding protein Li 181mP) (V9HVY4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAGPNQLCIRRWTTKHVAVWLKDEGFFEYVDILCNKHRLDGITLLTLTEYDLRSPPLEIKVLGDIKRLMLSVRKLQKIHIDVLEEMGYNSDSPMGSMTPFISALQSTDWLCNGELSHDCDGPITDLNSDQYQYMNGKNKHSVRRLDPEYWKTILSCIYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDSVPRIPWAFAMTEVCGMILCYIWLLVLLLHKHRSILLRRLCSLMGTVFLLRCFTMFVTSLSVPGQHLQCTGKIYGSVWEKLHRAFAIWSGFGMTLTGVHTCGDYMFSGHTVVLTMLNFFVTECKYLFSASMRIR
Protein: NAC domain containing protein 63 (NAM (No apical meristem)-like protein) (Q9M3C9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- non-specific serine/threonine protein kinase
- Glutaredoxin family protein
- Putative pectinesterase
- non-specific serine/threonine protein kinase
- UDP-glycosyltransferase 79B5
- At1g60280
Sequence:
MSPPSTIAYVLPPGFKFVPNDEEVIHCYLKPYSDGNTNVLLHVPIHLVNIYESNPQTLSEEFQKGNDKEWFIITERNKVDQGLSQTKRVGYGAKRQKRVDTNGGYWHATVAAQKINAGDGVVRNKRPLAYYVGKPSEGVKTDWLMQEYSLDHSSHNNDKDYTLCKIYLTPQATKMNKEVGEEKKKQKKGEAVVSVAPVEALEEQLPCNVEYHQPLAPLDSCQPQPHDLAYQQQQFCPGPLDSYQPQPHDMENQQPHNEKLKKEEDVEQLDLHQPDQGKGC
Protein: histidine kinase (EC 2.7.13.3) (Q72EN7)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Sigma-54 dependent DNA-binding response regulator
- histidine kinase
- histidine kinase
- histidine kinase
- Phosphate regulon transcriptional regulatory protein PhoB
- Response regulator
- Response regulator
- Chemotaxis protein CheY
- Response regulator/anti-anti-sigma factor
- Response regulator
Sequence:
MPSAPPENGHRRHKPYSLQIRFMLGLMGILVTMGLFFAASLYMHLNQLVSAEARSKASLILSHAESVQSYVRNTLRPAMYRDLPADRFIIEAMSTSFVTRHVMSDPAHGNEAFEYRRVAIDARNPSFEAASLERGLIERFKADPTLTRIEETENGERGERFITARPVRFEEACMKCHGAPEDAPPQLIALYGPVRGFGRSPGELAGIDLVSIAIDESLSSAKEAITSFATLFAVGMVILFAIIHTFFTRLVVYNLRRMGAAMQRQLGFDANGSMLDRLRRDEEIEDVINTMEGFTRQLAQARQQLKDYASNLESMVATRTADLQAEADARSADVGLFVELLAGLNRSQGKHDLLGTSLELIARRFNAASAAYACLLSGTESFSWPADAAPPQLPEDMGVLLGDGLPRLTPRAWYIPVQTTETSRGLLCLFWREDRPHGPRTPELAQALGRQLGIALDNIDVLDNLLRQNTLLDSIFEGISDPLLLLDGHGAIVFANGSAERMAKAIPGGLPRLLDDAGLPDAVAEPAQMEIALEDGRSFVINVYPLAQTHGRNRSVVYLRETTREKRMFDQMRQQEKLASVGRLAAGLAHEINNPLGVIMCYAELLQTQVGDSQARHDLDIILRHTLQAQRVVRDLLDFARPKDTRCEACDINDVLSDIVEIFMPKARKSGVNVSLDLEPDLPRVYADRDSLGQVFSNLLLNALDAVPERTGTIAISTCGKGYGVTVTIRDNGPGIPEAHRDRIFDPFYTTKETGRGTGLGLAVVYGIMRDLNGNIDVSTDDGATFILHFPADGDPRDHANDM
Protein: 11-beta-hydroxysteroid dehydrogenase type 2 (Corticosteroid 11-beta-dehydrogenase isozyme 2) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) (Q7SZK9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MEDYLDWIYMGVMSAFVGGAMKKVLASHVSAAPTVVAWLGVTLLVERLWFFCVPAVLVLAALCLACCLYSVRTAPAPTLPVQGKAVFITGCDTGFGKAAARRLDAQGFEVFATVLDLCGEGAKELQKTCSPHLTLLQVDITQPQQVQQALLDTKAKLGLRGLWGLVNNAGVCVNFGDAELSLMSNYRGCMEVNFFGTLNVTKTFLPLLRQAKGRIVTISSPAGEQPFPCLAAYGASKAALNLFINTLRHEMEPWGVKVSTILPSSYKTGQSGNQEYWENQYKSLIHNLSTGLLEEYGEDYTHETKELFQHFAQSANEDLSPVINTISEALLSPRPLVRYYAGPGVGLMNFVYSYFPLSLSDKFLQRLFVQKKIIPRALRKENNNNNNINNNVEKIKK
Protein: Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase) (Inositol-triphosphate 5/6-kinase) (Ins(1,3,4)P(3) 5/6-kinase) (EC 2.7.1.159) (Q8BYN3)
Organism: Mus musculus (Mouse)
Function: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis.
Interaction partners:
- Inositol polyphosphate multikinase
- Inositol-pentakisphosphate 2-kinase
- Multiple inositol polyphosphate phosphatase 1
- Inositol-trisphosphate 3-kinase A
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
- Kinase
- Inositol-trisphosphate 3-kinase C
- Inositol polyphosphate-4-phosphatase type I A
- Inositol polyphosphate 1-phosphatase
- Inositol polyphosphate 5-phosphatase K
Sequence:
MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGEDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCGSMKGQDTPWKTETEAGNMGAGASAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ
Protein: Uncharacterized protein IRC10 (Increased recombination centers protein 10) (Q08118)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Accumulates dyads protein 3
- Transmembrane 9 superfamily member 2
Sequence:
MFIEYSRLPGFESINISFSRGMLRLAKFTNFATYKQKLEYFRLLAGSNKYIQRISVADFERHPDEINYIYIILISILQMEECMPVLVLCPTVYWVRFHWPGKCSVNSLNFTNETLKSAFHAVFTPYFALMKKVLGRIKNNMLLFAEPHANLNNLFVKHFHDLIYKSVKDEKTGEAILYLRTNVNVPNVFIDDKRAVFHGDGMKIGKFTGKFLCFSFKRTIRWSKLDSVDSFAVTTVNYRVSVNWEKTPRKTFLSLDSDTKNLHYISKKILNKKGKNATTSKTTKSSCTSENVCDDKTFSVEFPLTTSAKTEYLLRSNFSLEKINESNNPTLQELTLNRTHRLYRSNFRNEQSTTQRKFEKIGRTVSTDSGNKLLTFPEQKATRDSNPFSIELTHATVISSDESALKDTTNQAIAEMQRITPAIAKTISRRTANWVCSNPAPDPYGEPSTWSRILTPNLKIISESSPYYPVHLASPNSTFSRDQSVRSVVMRRSSVCVEKQNSFFRNYEHFKNILSRRTIKVKTSCPRLSVDVSDNKRENLSQEHLILPNKSREKVNRFKNCLHRVAEALRAAKENWDQHNPRNSIH
Protein: Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75) (P55259)
Organism: Homo sapiens (Human)
Function: Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.
Subcellular location: Zymogen granule membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Secreted {ECO:0000269|PubMed:10760606}. Cell membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D733}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Membrane raft {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Endosome {ECO:0000250|UniProtKB:Q9D733}. Note=Secreted, after cleavage, in the pancreatic juice. {ECO:0000305|PubMed:10760606}.
Interaction partners:
- GTP-binding protein 1
- Platelet glycoprotein 4
- Scavenger receptor cysteine-rich type 1 protein M130
- NPC intracellular cholesterol transporter 1
- Platelet glycoprotein V
- Synaptic vesicle glycoprotein 2C
- Synaptic vesicle glycoprotein 2B
- Synaptic vesicle glycoprotein 2A
- Platelet glycoprotein VI
- Pancreatic polypeptide prohormone
Sequence:
MPHLMERMVGSGLLWLALVSCILTQASAVQRGYGNPIEASSYGLDLDCGAPGTPEAHVCFDPCQNYTLLDEPFRSTENSAGSQGCDKNMSGWYRFVGEGGVRMSETCVQVHRCQTDAPMWLNGTHPALGDGITNHTACAHWSGNCCFWKTEVLVKACPGGYHVYRLEGTPWCNLRYCTVPRDPSTVEDKCEKACRPEEECLALNSTWGCFCRQDLNSSDVHSLQPQLDCGPREIKVKVDKCLLGGLGLGEEVIAYLRDPNCSSILQTEERNWVSVTSPVQASACRNILERNQTHAIYKNTLSLVNDFIIRDTILNINFQCAYPLDMKVSLQAALQPIVSSLNVSVDGNGEFIVRMALFQDQNYTNPYEGDAVELSVESVLYVGAILEQGDTSRFNLVLRNCYATPTEDKADLVKYFIIRNSCSNQRDSTIHVEENGQSSESRFSVQMFMFAGHYDLVFLHCEIHLCDSLNEQCQPSCSRSQVRSEVPAIDLARVLDLGPITRRGAQSPGVMNGTPSTAGFLVAWPMVLLTVLLAWLF
Protein: 25.3 kDa vesicle transport protein SEC22-1 (AtSEC22) (Q94AU2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: V-SNARE involved in vesicle trafficking from the ER to the Golgi complex and required for early secretion. Involved in endoplasmic reticulum (ER) biogenesis and functions as well as for Golgi-stack integrity. Essential for gametophytes development. Involved in cesium Cs(+) accumulation, a non-essential cation.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:P22214}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P22214}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21205036}; Single-pass type IV membrane protein {ECO:0000269|PubMed:21205036}.
Interaction partners:
- At3g24315
- Bet1-like SNARE 1-1
- Syntaxin-81
- Membrin-11
- Bet1-like SNARE 1-2
- Syntaxin-31
- Syntaxin-32
- Membrin-12
- At3g55600
- Membrane fusion protein Use1
Sequence:
MVKMTLIARVTDGLPLAEGLDDGRDLPDSDMYKQQVKALFKNLSRGQNDASRMSVETGPYVFHYIIEGRVCYLTMCDRSYPKKLAFQYLEDLKNEFERVNGPNIETAARPYAFIKFDTFIQKTKKLYQDTRTQRNIAKLNDELYEVHQIMTRNVQEVLGVGEKLDQVSEMSSRLTSESRIYADKAKDLNRQALIRKWAPVAIVFGVVFLLFWVKNKLW
Protein: Stress-response A/B barrel domain-containing protein (Q387B9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- FAD/NAD
- Aminomethyltransferase
- Nonspecific lipid-transfer protein, putative
- propanoyl-CoA C-acyltransferase
- Peroxisome targeting signal 1 receptor
Sequence:
MSAKMCHVVMFALDATKFAANLPGSELQRHLKLLRETVPGLLEINMGPTGTDLFPGYVDCSGGFTHCLVSKHTDVKALQEYVAHPNHVTFAELLKASYSKPPIRVDFELKE
Protein: Tyrosinase (Epidermis tyrosinase) (Monophenol monooxygenase) (Skin tyrosinase) (EC 1.14.18.1) (Q0MVP0)
Organism: Pelophylax lessonae (Pool frog) (Rana lessonae)
Function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone.
Subcellular location: Melanosome membrane {ECO:0000269|PubMed:18950728, ECO:0000269|PubMed:19101648}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MESTTVLLAASTLLLVLHASYGQFPRACSTAQVLLSKECCPVWPGDNSSCGEVSGRGVCQDVVPSNSPVGAQFPFSGIDDRENWPIVFYNRTCQCQGNFMGYNCGECRFGYTGPNCTVRRNMIRKEIFRMTTAEKDKFIAYLNLAKRTISQDYVISTGTYEQMNNGSNPMFADINVYDLFVWLHYYASRDAFLEDGSVWANIDFAHEAPGFPPWHRFFLLLWEREIQKVAADDNFTIPFWDWRDAQQCDLCTDEFFGGTHPTSNNLLSPASFFSSWQVICSQPEEYNRLRIICNGTNEGPLLRSPGRHDRNRTPRLPTSADVEACLSLTDYETGAMDRFANFSFRNTLEGYAVPASGIANRSQSNMHNSLHVFMNGSMSNVQGSANDPIFVLHHAFVDSLFEQWLRRHQPSLDVYPEANAPVGHNREYNMVPFIPLFTNGEFFVQSRDLGYDYDYLAESGSIEDFLLPYLEQARQIWQWLLGAAVVGGLVTAVIATIISLTCRRKRRTKTSEETRPLLMEAEDYHATYQSNL
Protein: Large ribosomal subunit protein uL22m (54S ribosomal protein L22, mitochondrial) (O74464)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein bL17m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein uS14m
- Large ribosomal subunit protein bL36m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL2m
Sequence:
MKYINQFMKISKGFLVPSSTIGLNSKTYHYKFPLLSFVREFSNGSYLRESAQNPANLGSQKGSDIFSMLANQKDDSNRQQKEERVKERPRSRISFKKQETMDPSYTLQSMVLRSSLKKVGALCRQIAHKPFYHALLQMKMSDKKISKYIATALVSARENAVREAGLDESTLYVDQIWVGKAKYLKKLITMGRGGRAIERSPRVRVTVVLRDERALLRDLQRRQQRLERKKVWTPLPNRPIYLKSNFFTC
Protein: Histone deacetylase complex subunit SAP30 (30 kDa Sin3-associated polypeptide) (Sin3 corepressor complex subunit SAP30) (Sin3-associated polypeptide p30) (O88574)
Organism: Mus musculus (Mouse)
Function: Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.
Subcellular location: Nucleus.
Interaction partners:
- Histone-binding protein RBBP4
- Histone deacetylase 2
- Histone deacetylase 1
- Paired amphipathic helix protein Sin3a
- Histone deacetylase complex subunit SAP18
- Sin3 histone deacetylase corepressor complex component SDS3
- Histone-binding protein RBBP7
- Paired amphipathic helix protein Sin3b
- AT-rich interactive domain-containing protein 4B
- Nuclear receptor corepressor 2
Sequence:
MNGFTPEEMSRGGDAAAAVAAVVAAAAAAASAGNGNAAGGGAEVPGAGAVSASGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFKSIPVNEKDTLTCFIYSVRNDKNKSDLKADSGVH
Protein: Ubiquitin-like protein atg-12 (Autophagy-related protein 12) (Q10931)
Organism: Caenorhabditis elegans
Function: Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin-like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzyme promoting atg-3-mediated lgg-1 lipidation (Probable). Involved in the degradation of P-granules by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. Involved in the elimination of paternal mitochondria in fertilized eggs. Involved in xenophagy, the autophagy-mediated degradation of pathogens and pathogen products, such as toxins. Also plays a role in membrane-pore repair.
Subcellular location: Preautophagosomal structure membrane {ECO:0000269|PubMed:24185444}; Peripheral membrane protein {ECO:0000269|PubMed:24185444}. Note=Recruited to the membrane of autophagic vesicles. {ECO:0000269|PubMed:24185444}.
Interaction partners:
- Ubiquitin-like-conjugating enzyme ATG10
- Autophagy-related protein 5
- Ubiquitin-like modifier-activating enzyme ATG7
- Ubiquitin-like-conjugating enzyme ATG3
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Autophagic-related protein 16.2
- Autophagy-related protein 18
- Autophagic-related protein 16.1
- Serine/threonine-protein kinase unc-51
- Autophagy-related protein 9
Sequence:
METETATTPTGNTEPTAAASAEPPKSDKVTVRLRNIADAPVLKNKKMVVNPTDTVASFILKLRKLLNIQANNSLFLYIDNTFAPSPDTTFETLSRCYSVKITDKEILELQYSITPAYG
Protein: Ubiquinol-cytochrome c reductase core protein 2 (H3BRG4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKLLTRAGSFSRFYSLKVAPKVKATAAPAGAPPQPQDLEFTKLPNGLVIASLENYSPVSRIGLFIKAGSRYEDFSNLGTTHLLRLTSSLTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQPQLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNMRGGLGLSGAKANYRGGEIREQNGDSLVHAAFVAESAVAGSAEANAFSVLQHVLGAGPHVKRGSNTTSHLHQAVAKATQQPFDVSAFNASYSDSGLFGIYTISQATAAGDVIKAAYNQVKTIAQGNLSNTDVQAAKRQRSLFLARSQWQQVEIWDIHLLLMSCNTDAHITGES