wanglab/gogpt-training-data huggingface dataset:
Protein: Dual specificity protein phosphatase 13A (DUSP13A) (EC 3.1.3.16) (EC 3.1.3.48) (Branching-enzyme interacting DSP) (Muscle-restricted DSP) (MDSP) (Q6B8I1)
Organism: Homo sapiens (Human)
Function: Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15252030}.
Interaction partners:
Sequence:
MAETSLPELGGEDKATPCPSILELEELLRAGKSSCSRVDEVWPNLFIGDAATANNRFELWKLGITHVLNAAHKGLYCQGGPDFYGSSVSYLGVPAHDLPDFDISAYFSSAADFIHRALNTPGAKVLVHCVVGVSRSATLVLAYLMLHQRLSLRQAVITVRQHRWVFPNRGFLHQLCRLDQQLRGAGQS
Protein: Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (P27881)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P52789}; Peripheral membrane protein {ECO:0000250|UniProtKB:P52789}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P52789}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane. The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein. Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis. {ECO:0000250|UniProtKB:P52789}.
Interaction partners:
- Glucose-6-phosphate isomerase
- RCG30218, isoform CRA_b
- Non-selective voltage-gated ion channel VDAC1
- Uncharacterized protein.
- Glucose-6-phosphatase catalytic subunit 1
- Glucose-6-phosphatase 3
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
- ATP-dependent 6-phosphofructokinase, liver type
- Phosphoglucomutase-1
- ATP-dependent 6-phosphofructokinase, muscle type
Sequence:
MIASHMIACLFTELNQNQVQKVDQFLYHMRLSDETLLEISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVSDIEEDKDGIEKAYQILMRLGLNPLQEDCVATHRICQIVSTRSASLCAATLAAVLWRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLESLKLSHEQLLEVKRRMKVEMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLDDLRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDKIRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR
Protein: Z-DNA binding protein 1 (A2APF7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAEAPVDLSTGDNLEQKILQVLSDDGGPVKIGQLVKKCQVPKKTLNQVLYRLKKEDRVSSPEPATWSIGGAASGDGAPAIPENSSAQPSLDERILRFLEANGPHRALHIAKALGMTTAKEVNPLLYSMRNKHLLSYDGQTWKIYHSRQEGQDIAHSGVTQESPAIICQHNPVNMICQQGANSHISIANSNAIQIGHGNVIVREKACGEPGPRTSHPLPLAWDASAQDMPPVAHGAQYIYMDKSLLQQVQLGHHNEMSLVGDAGKHPSYSFSDSPPEVSTTTADPGASFNMQTSEPGPHPEGDTVQTVHIKSCFLEDATIGNGNKMTIHLRSKGEVMESGDSEEPKKEDTGTSSEATPPRSCQHTPSDSMLPTSELRAMALGDSSPQTTEPVLREHEVQDIESSQDTGLSKQ
Protein: F17H15.1/F17H15.1 (KH domain-containing protein) (O82762)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RNA-binding
- RNA polymerase II C-terminal domain phosphatase-like 1
- Putative defensin-like protein 145
- tRNA
- GPN-loop GTPase 3
- Glycine-rich RNA-binding protein RZ1A
- V-type proton ATPase subunit d2
- Neutral ceramidase 3
- 30-kDa cleavage and polyadenylation specificity factor 30
Sequence:
MADESQYSSDTYSNKRKYEEPTAPPPSTRRPTGFSSGPIPSASVDPTAPTGLPPSSYNSVPPPMDEIQIAKQKAQEIAARLLNSADAKRPRVDNGASYDYGDNKGFSSYPSEGKQMSGTVPSSIPVSYGSFQGTTKKIDIPNMRVGVIIGKGGETIKYLQLQSGAKIQVTRDMDADPNCATRTVDLTGTPDQISKAEQLITDVLQEAEAGNTAGSGGGGGRRMGGQAGADQFVMKIPNNKVGLIIGKGGETIKSMQAKTGARIQVIPLHLPPGDPTPERTLQIDGITEQIEHAKQLVNEIISGENRMRNSAMGGGYPQQGGYQARPPSSWAPPGGPPAQPGYGGYMQPGAYPGPPQYGQSPYGSYPQQTSAGYYDQSSVPPSQQSAQGEYDYYGQQQSQQPSSGGSSAPPTDTTGYNYYQHASGYGQAGQGYQQDGYGAYNASQQSGYGQAAGYDQQGGYGSTTNPSQEEDASQAAPPSSAQSGQAGYGTTGQQPPAQGSTGQAGYGAPPTSQAGYSSQPAAAYNSGYGAPPPASKPPTYGQSQQSPGAPGSYGSQSGYAQPAASGYGQPPAYGYGQAPQGYGSYGGYTQPAAGGGYSSDGSAGATAGGGGGTPASQSAAPPAGPPKASPKS
Protein: Mevalonate kinase (MK) (EC 2.7.1.36) (Q03426)
Organism: Homo sapiens (Human)
Function: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14730012}. Peroxisome {ECO:0000250|UniProtKB:P17256}.
Interaction partners:
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Diphosphomevalonate decarboxylase
- Phosphomevalonate kinase
- Immunoglobulin heavy constant delta
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Farnesyl pyrophosphate synthase
- Cystathionine gamma-lyase
- Squalene synthase
- Acetyl-CoA acetyltransferase, mitochondrial
- Acetyl-CoA acetyltransferase, cytosolic
Sequence:
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Protein: Cytochrome c oxidase subunit 7A2 like (H0YBD2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
FSGFTQKLAGAWASEAYSPQGLKPVVSTEAPPIIFATPTKLTSDSTVYDYAGKNKVPELQKFFQETYLQTILFLWLLETPVVGILDKGTFPAGLQ
Protein: 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (Q54UB5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmD11 is required for proteasome assembly (By similarity).
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome regulatory subunit 6A homolog
- Probable 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome regulatory subunit 7
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 6
- 26S proteasome regulatory subunit 10B
Sequence:
MNWKEQLEEIGNCQDSNKAIQDYNKILTIQESPDDIKEEAILRLAKLFVKIGKGDQLPTLLRSVRPFFDKISKPKTDKIVRNFIDIFSTVPDNLTTLIEFVKENIQWCKDTNRIYLRQRLETKLFTLMFEAKDYANALSGLTTLLTEIKRLDDKPLLVEIQLVESRIQHALKNIPKARAALTSARTNANTIYCPPKLQAEIDMQSGILHSEEKDYKTAFSYFFESYETYDSLEDPFAMKALKYMLLCKIMTNQTDDVHALVNGKIGLKYHNNRSIEAITQISKSHAKRSLHMFQEVTKEFSDQLSDDPIIHSHLTELYSNLLEQNLCRIIEPFSRVEISHIAKLIDLPVDVVERKLSLMILDKKYNGILDQGTGTLIVFEEQKEDKLFNCSLETIGALSRVVDLLYEKTNKLS
Protein: Chlorophyll a-b binding protein 3, chloroplastic (Chlorophyll a-b protein 180) (CAB-180) (LHCII type I CAB-3) (Q8VZ87)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular location: Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Interaction partners:
- Chlorophyll a-b binding protein CP26, chloroplastic
- Chlorophyll a-b binding protein CP29.1, chloroplastic
- Photosystem II CP43 reaction center protein
- Chlorophyll a-b binding protein
- Photosystem II CP47 reaction center protein
- Photosystem II D2 protein
- Chlorophyll a-b binding protein 2, chloroplastic
- Photosystem II protein D1
- Oxygen-evolving enhancer protein 1-1, chloroplastic
- Chlorophyll a-b binding protein 3, chloroplastic
Sequence:
MAASTMALSSPAFAGKAVNLSPAASEVLGSGRVTMRKTVAKPKGPSGSPWYGSDRVKYLGPFSGESPSYLTGEFPGDYGWDTAGLSADPETFARNRELEVIHSRWAMLGALGCVFPELLARNGVKFGEAVWFKAGSQIFSDGGLDYLGNPSLVHAQSILAIWATQVILMGAVEGYRVAGNGPLGEAEDLLYPGGSFDPLGLATDPEAFAELKVKELKNGRLAMFSMFGFFVQAIVTGKGPIENLADHLADPVNNNAWAFATNFVPGK
Protein: Sesquiterpene synthase Cop (Alpha-copaene synthase) (EtCop) (EC 4.2.3.133) (H9L9E5)
Organism: Eleutherococcus trifoliatus (Climbing ginseng) (Zanthoxylum trifoliatum)
Function: Sesquiterpene synthase involved in the biosynthesis of volatile compounds (Ref.1). Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into alpha-copaene (Ref.1). Not active with geranyl diphosphate (GPP) as substrate (Ref.1).
Interaction partners:
Sequence:
MATYLQASSGPCSTIVPEITRRSANYHPNIWGDQFLKYNSFDLSKTDANTKEHFRQLKEEVKKMLVDAGPNQQLNLIDDIQRLGVAYQFEAEIDAALQRMNVIFQGNDDDLHTISLRFRLLRQHGYNVSSDVFRKFMDNNGKFKECLISDLRGVLSLYEATHFRVHGEDILEDALEFTTSHLERLKSHLKNPLAAQVIRALKCPIHKGLNRLEAKHYISIYQQEDDSHNKVLLNFAKLDFNLLQKMHQGELSHITRWWKELNFAKKLPFARDRVVECYFWILGVYFEPQYLIARRFLTKIIAMASVADDIYDVYGTLEELVILTDAIERWDMGALDQIPECMRVYHRALLDVYTEMEEEMAKTGRPSYRVHYAKEAYKELVRQYLAEAKWFQEDYDPTLEEYLPVALISGGYKMLATHSFVGMGDLATKEAFDWVSNNPLIVKASSVICRLSDDMVGHEVEHERGDVASAVECYMKQYGVTKQEVYIEFQKQISNAWKDMNQECLHPTTVTMPLLTVIFNMTRVINLLYDEEDGYTNSNTRTKDFITSVLIDPVQI
Protein: PAN2-PAN3 deadenylation complex catalytic subunit Pan2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) (Q8BGF7)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation (By similarity).
Subcellular location: Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:18625844}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03182}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000255|HAMAP-Rule:MF_03182}.
Interaction partners:
- PAN2-PAN3 deadenylation complex subunit Pan3
- Polyadenylate-binding protein 1
- Polyadenylate-binding protein 5
- Polyadenylate-binding protein
- Polyadenylate-binding protein 1-like
- Polyadenylate-binding protein
- Polyadenylate-binding protein
- Polyadenylate-binding protein 5
- Trinucleotide repeat-containing gene 6C protein
- Ubiquitin carboxyl-terminal hydrolase 54
Sequence:
MNFEGLDPGLAEFSPAMHSTLDPVLDAHLNPSLLQNVELDPEGVALEALPVQESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQVNGGDDIRQIQSLENGILFLTKNNLKYMARGGLIIFDYLLDENEDMHSVLLTDNSTLLVGGLQNHVLEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRSFKVEHEFDAFSGSLSDFDVHGNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCEPTGLANPADIFHVNPVGPLLMTFDVSASKQALAFGDSEGCVHLWTDSPEPSFNPYSRETEFALPCLVDSLPPLDWSQDLLPLSLIPVPLTTDALLSDWPAANSAPAPRRAPPVDAEILRTMKKVGFIGYAPNPRTRLRNQIPYRLKESDHEFDNFSQVTESPTGREEEPLHTVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASALGLILADSDEASGKGSLARLIQRWNRFILTQLHQDMQELEVPQAYRGAGGSFCSSGDSIIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPEDKTGKNYDFAQVLKRSICLEQNTQAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFWRLQAEVAFKIAVKKYGGEMKSKEFALADRKELRSPEGFLCSSIEELKNVWLPFSIRMKMTKNKGLDVCNWADEHELSSLGAPSQWGPARAEEELGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKYEAVQFDMNWKVPAILYYVKRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQVGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPESQTSPKNAAVFSVLAL
Protein: Prostate and testis expressed 1 (E9Q658)
Organism: Mus musculus (Mouse)
Interaction partners:
- Prostate and testis expressed protein 3
- Prostate and testis expressed protein 2
- Cysteine-rich secretory protein 2
Sequence:
MCKSQLLRCLIFLCYLKVFSGSLPGDANKPGKVLVHENNNVVEIVQCRMCHLKFPGENCTRGRGICTATAEEACMAGKVFKRDGTIWLNFMGCLKNCANVKKIKWGPYLVDFRCCRGQDMCNENF
Protein: Serine hydroxymethyltransferase 2 (SHM2) (SHMT 2) (Serine methylase 2) (EC 2.1.2.1) (P9WGI7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00051, ECO:0000305|PubMed:12913008}.
Interaction partners:
- L-serine dehydratase
- Probable glycine dehydrogenase
- Aminomethyltransferase
- Bifunctional purine biosynthesis protein PurH
- Bifunctional protein FolD
- Phosphoribosylglycinamide formyltransferase
- Glycine cleavage system H protein
- Phosphoserine phosphatase SerB2
- Probable cystathionine beta-synthase Rv1077
- Formyltetrahydrofolate deformylase
Sequence:
MNTLNDSLTAFDPDIAALIDGELRRQESGLEMIASENYAPLAVMQAQGSVLTNKYAEGYPGRRYYGGCEFVDGVEQLAIDRVKALFGAEYANVQPHSGATANAATMHALLNPGDTILGLSLAHGGHLTHGMRINFSGKLYHATAYEVSKEDYLVDMDAVAEAARTHRPKMIIAGWSAYPRQLDFARFRAIADEVDAVLMVDMAHFAGLVAAGVHPSPVPHAHVVTSTTHKTLGGPRGGIILCNDPAIAKKINSAVFPGQQGGPLEHVIAAKATAFKMAAQPEFAQRQQRCLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDGQQAEDRLAAVDITVNRNAVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADLIAAALTATNDDQLGPLRAQVQRLAARYPLYPELHRT
Protein: Carbonic anhydrase (EC 4.2.1.1) (Q2TWF5)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein
- Ribosome production factor 2 homolog
- Uncharacterized protein
- Ribosomal protein L5
- Brix domain-containing protein
- Nucleolar GTP-binding protein 1
- Small-subunit processome Utp12 domain-containing protein
- Ribosomal RNA-processing protein 12-like conserved domain-containing protein
- Small-subunit processome Utp21 domain-containing protein
- Ribosome assembly protein Noc2
Sequence:
MKFATTLLPLLAGASAFCIHSPVMRRAAGGLDDANKFNYTGLGGPLNWYGLDEANEACAKGKHQSPIVIDSAAIDYAASGSLKLDLPLADGSKLENLGFGLQVTLTNGSLTANSKTYTLAQFHFHTPSEHHVNEEHFPMEVHFVFQTAAKETAVVGFFFQLSEVGDSVPLFDSVFAPIDNIPDAGTSTTTGQLDFGGLLDHFNRHGVYQYTGSLTTPPCTEEVMWNLSTEPLPLTVQGYNKVKKIIKYNARYTQNALGQDNLLEVAAQKLNSIR
Protein: Class E vacuolar protein-sorting machinery protein HSE1 (P38753)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:12055639, ECO:0000269|PubMed:14562095}; Peripheral membrane protein {ECO:0000269|PubMed:12055639, ECO:0000269|PubMed:14562095}; Cytoplasmic side {ECO:0000269|PubMed:12055639, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Vacuolar protein sorting-associated protein 27
- Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease
- Polyubiquitin
- Vacuolar protein-sorting-associated protein 36
- Vacuolar protein sorting-associated protein 28
- Vacuolar protein-sorting-associated protein 25
- Vacuolar protein sorting-associated protein 20
- Multivesicular body sorting factor 12
- Vacuolar protein-sorting-associated protein 24
- DOA4-independent degradation protein 4
Sequence:
MSSSAIKIRNALLKATDPKLRSDNWQYILDVCDLVKEDPEDNGQEVMSLIEKRLEQQDANVILRTLSLTVSLAENCGSRLRQEISSKNFTSLLYALIESHSVHITLKKAVTDVVKQLSDSFKDDPSLRAMGDLYDKIKRKAPYLVQPNVPEKHNMSTQADNSDDEELQKALKMSLFEYEKQKKLQEQEKESAEVLPQQQQQHQQQNQAPAHKIPAQTVVRRVRALYDLTTNEPDELSFRKGDVITVLEQVYRDWWKGALRGNMGIFPLNYVTPIVEPSKEEIEKEKNKEAIVFSQKTTIDQLHNSLNAASKTGNSNEVLQDPHIGDMYGSVTPLRPQVTRMLGKYAKEKEDMLSLRQVLANAERSYNQLMDRAANAHISPPVPGPALYAGMTHANNTPVMPPQRQSYQSNEYSPYPSNLPIQHPTNSANNTPQYGYDLGYSVVSQPPPGYEQ
Protein: Protein NRT1/ PTR FAMILY 3.1 (AtNPF3.1) (Q9SX20)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as an efflux-type nitrite transporter. Not regulated by the PII protein involved in the regulation of nitrite uptake into higher plant chloroplasts.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MEEQSKNKISEEEKQLHGRPNRPKGGLITMPFIFANEICEKLAVVGFHANMISYLTTQLHLPLTKAANTLTNFAGTSSLTPLLGAFIADSFAGRFWTITFASIIYQIGMTLLTISAIIPTLRPPPCKGEEVCVVADTAQLSILYVALLLGALGSGGIRPCVVAFGADQFDESDPNQTTKTWNYFNWYYFCMGAAVLLAVTVLVWIQDNVGWGLGLGIPTVAMFLSVIAFVGGFQLYRHLVPAGSPFTRLIQVGVAAFRKRKLRMVSDPSLLYFNDEIDAPISLGGKLTHTKHMSFLDKAAIVTEEDNLKPGQIPNHWRLSTVHRVEELKSVIRMGPIGASGILLITAYAQQGTFSLQQAKTMNRHLTNSFQIPAGSMSVFTTVAMLTTIIFYDRVFVKVARKFTGLERGITFLHRMGIGFVISIIATLVAGFVEVKRKSVAIEHGLLDKPHTIVPISFLWLIPQYGLHGVAEAFMSIGHLEFFYDQAPESMRSTATALFWMAISIGNYVSTLLVTLVHKFSAKPDGSNWLPDNNLNRGRLEYFYWLITVLQAVNLVYYLWCAKIYTYKPVQVHHSKEDSSPVKEELQLSNRSLVDE
Protein: LD23303p (Twister, isoform A (EC 3.6.4.13)) (Twister, isoform B) (Q9VCH8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- LP07472p
- Uncharacterized protein
- Csl4
- 5'-3' exoribonuclease 1
- Exosome complex component 10 homolog
- Ribosomal RNA-processing protein 42
- Protein HBS1
- Exosome complex component RRP45
- FI07225p
- FI06805p
Sequence:
MNEIRGEDNLERLRNYILRPELSLHNPLPDVLPRKFDPMRLLHAPRCPGSTKLAPRRDQSGHILEFVELDLEAVGANANNSMSMQREPGLLEDATRGSHSNFPFWPGGFDEQRQQIAALDVSNFQFGDKLLTVPPGFSSGYDFFQSQSVTLPPVVADPSNVDLLENLEQDLDVQEWMKLTRSEETSSTGTPKSPKQSNVQLPSEEFRDVDDHIMKADLKPVLNISTTTKNFKSDWAEMVDISQPINNFKEQIPCPAMDFPFELDVFQKQAILKLEQRQYVFVAAHTSAGKTVVAEYAIALSKRDLTRTIYTSPIKALSNQKYRDFRKTFKDVGLITGDLQIEPTASCLIMTTEILRSMLYCGSDVTRDLEWVIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPNTLELADWVGSTKKRKVYVISTLKRPVPLTHFLYTGAGGKSRDDIFLLVDAQGKYLQGNYEKAVERKKEMQGKAKGGGGGPRNHLNAKQEQYTWIGLIDFLRRSNMMPVVAFTLSRNRCDSNLAALQSVDLNTEKEKGAVQKFFLQCLAKLKPPDRTIPQVLVLKDALERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATETFAMGVNMPARTVVFDSCKKFDGLEMRNLKPGEYIQMAGRAGRRGHDETGTAIIMCKGSVPPSMELRPMILGLPEKLQSQFILRYAVILTCLRIESIKVEDIMKFSFKEFNLKLQLPTQQKQLRLAEDKFAMLPTLGEHLQPLVNFYDKAVEYWKEKHRIMKFVVTQPKIQKELKAGRVIVITQGKHYNKLAILLNTKSVPGKDTIYKVLVLDHQFKAKDSNSLQQGELYYKILSLTPRNMTFQPVGIGGHTVLDIKAIDIISITKSTLKVDADAIIRNWEQRQLERFKDSPPSGSVVKAVTELNQLNESYIDNPDNIKYVNLSKEIIVNADSEVAMLNYVDHLLRKVGEFLPHTNIAGFEQEFAKVYERRMLEIHIEELRFKNSARNLTLYPDYCNKLKVLRALKYIDELDEVTLKGKVACEMGQNELLITELILCNMFNDLEPAEIAALLSGLVFQAKMQDKPVIPEALKECVAAFEQINDTILAEEQRFQAAIETDNRLNFGLLEVVYEWARNKPFAEIMKLTTVQEGIIVRCIQQLNETLRDVKTAAIRIGNPGLQSKMEEASAAIKRDIVFTASLYTEL
Protein: UPF0540 protein At1g62000 (Q39168)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MNATKFVVLLVIGILCAIVTARQVKDLSTETKLGASLPKTTTKGIGAQLSATGTTYSTSSVVSYANGFNNPKGPGANSFESANTFTSGQVTAKGRKARVSSTSASAAEGDAAAAVTRKAAAARANGKVASASRVKGSSEKKKGKGKKD
Protein: Glutathione S-transferase alpha-3 (EC 2.5.1.18) (GST 2-2) (GST A3-3) (GST AA) (Glutathione S-transferase Yc-1) (GST Yc1) (P04904)
Organism: Rattus norvegicus (Rat)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively (By similarity). Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Glutathione S-transferase theta-1
- Glutathione S-transferase Mu 7
- Glutathione S-transferase omega-1
- Glutathione S-transferase theta-2
- Microsomal glutathione S-transferase 1
- Cytochrome P450 1A1
- Epoxide hydrolase 1
- Glutathione peroxidase 1
- Glutathione S-transferase Mu 4
- Glutathione S-transferase omega-2
Sequence:
MPGKPVLHYFDGRGRMEPIRWLLAAAGVEFEEQFLKTRDDLARLRNDGSLMFQQVPMVEIDGMKLVQTRAILNYIATKYNLYGKDMKERALIDMYAEGVADLDEIVLHYPYIPPGEKEASLAKIKDKARNRYFPAFEKVLKSHGQDYLVGNRLSRADVYLVQVLYHVEELDPSALANFPLLKALRTRVSNLPTVKKFLQPGSQRKPLEDEKCVESAVKIFS
Protein: Lectin 5 (MtLec5) (Agglutinin LEC5) (A0A396HQY2)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: May be involved in arbuscular mycorrhizal (AM) symbiosis with AM fungi.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MHHTQHNTMANSIPKLLATQNPFSVSLSIFFFLLLLINNVKSDSLSFNFPKFDTDALNIVIDGDAKTTGGVLQLTKKDQFGNPSPHSVGFSAFFGAIQLSDKQSGKVADFTTEFSFVVNPKGSQLHGDGFAFYIASLDYDFPEKSSDGGFLGLFDKETAFNTSKNSIVAVEFDSFANEWDPNSPHIGIDINTIESSISVPWPIDRQPQGTIGKARISYNTASKDLSVFVTYPNSPAKVDVIVSYPIDFASVLSEWVYVGFSGATGQVAETHDILSWSFVSNL
Protein: RNA helicase (EC 3.6.4.13) (F5H658)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPECPKHFLPVVAVAVSLEQCLSKFEDLNKELGLVTC
Protein: Uncharacterized protein (Q3TRL8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MKEHILERNLIYVICVIKPIHTRNISKYMKKHILVRNPINVISVIKALHSSGTFEHMKEHILKRKPTNVINVVKPLHSSPIFEYMKEDIVERNPTNVMNVIKPFYSSSIFDYMKEDIVERNPMNVINVVKPFYIPAIFECMKEHILERNLTNVMNVIKPSYIPAILECMKEDIVERNPMNVINVVKPFCNPTIFECMKEHILERNPMNVINVVKPFYISAIFECMKEDIVERNPMNVINVVKRFYIPAIFECMKEHIVERNPMNVINVVKPFYIPAIFKCMKEHIVERNPMNVINVVKPFHIPAIFKCMKEHILERNPMNVINVVKPFCNPTIFENMKKHILERNLTNEINVVRPLHKAVILKPIK
Protein: Protein NUCLEAR FUSION DEFECTIVE 6, mitochondrial (Q93ZJ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q6NNL9}.
Interaction partners:
Sequence:
MATSAVLSGARSMLRAASSRSAAASTGRFASQAKSAPPLFRATARRSPLLSPLRNPVELSFCVESLLPYHSATASALMTSKLSISGQTYGWLSDACNDDV