wanglab/gogpt-training-data huggingface dataset:
Protein: F-box protein AUF1 (F-box protein At1g78100) (Protein AUXIN UP-REGULATED F-BOX PROTEIN 1) (Q9C9S2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the control of basipetal and acropetal auxin transport by promoting the distribution and expression of the auxin transporter PIN2. Promotes cytokinin-mediated cell expansion in the root elongation and differentiation zone, without affecting root cell division.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8LEA8}.
Interaction partners:
- F12K8.23 protein
- At4g17350)
- Probable indole-3-pyruvate monooxygenase YUCCA8
- F-box only protein 13
- Probable protein S-acyltransferase 19
Sequence:
MDAFDAIPDPVVIDILNRVGDVKTLIRCRSVSKRFNSLATQSESLLLQLDQILGATESDSEIDSPIASFFRSLFKSIHGLLPPIFSKPANSDEILTRSPKTPAQILSGFERIRNLEVELYGGDVKLEKGAAVKWKAEFGKTLKSCVIVAFRSATVNTSAATEAAAVVDGVVESDSEFVCGLKTRVVWTISALMAASTRHYLMRDLVKDHKEMEKLIVRDSDGEGTVVMDAAGMKEYRETEVRGDNKESERVGERTVVPSVRMSMRHAPSLMLKSGICLEAATLVVVRPTGVASDDNDVELVTEAFAGDGDDCMYGEAVTALLKRRRNVLEMNSF
Protein: (+)-3-carene synthase 1, chloroplastic (EC 4.2.3.107) (Terpene synthase (+)3car1) (PcTPS-(+)3car1) (Terpinolene synthase (+)3car1, chloroplastic) (EC 4.2.3.113) (R9QMW8)
Organism: Pinus contorta (Shore pine) (Lodgepole pine)
Function: Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (+)-car-3-ene and, to a lower extent, to terpinolene.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MSLISAVPLASSCVSKSLISSVREHTALRRAIATLQMSRRGKSVAASIRMSSATAGSDDGVKRRIGDYHSNLWDDNFIQSLSSPYGASSYGEHADRLIGEVKEIFNSFSIADGELISPVNDLLQQLWMVDNVERLGIDRHFQTEIKVALDYVYRYWSEEGIGCGRDSAFTDLNTTALAFRIFRLHGYTVSSDVFEHFKDQKGQFAASANDTELQTRSVFNLFRASLIAFPEEKVLEEAEKFAAAYLKAALQTLPVSGLSREIQYVFDYRWHSNLPRLEARSYIDILADNTISGTPDANTKKLLELAKLEFNIFHSVQQKELQCLWRWWKEWGCPELTFIRHRYVEFYTLVSGIDMVPEHATFRLSCVKTCHLITILDDMYDTFGTIDELRLFTAAVKRWDPSATECLPEYMKGVYMVLYETVNEMAKEAQKSQRRDTLGYVRQALEDYIGSYLKEAQWIATGYVPTFQEYFENGKLSSGHRIATLQPILTLSIPFPHHILQEIDFPSKFNDYAASILRLRGDTRCYKADSARGEEASCISCYMKDNPGSTQEDALNHINGMIEDMIKKLNWEFLRPDNNAPISSKKHAFNISRGLHHFYNYRDGYSVASKETKDLVIKTVLEPVLM
Protein: Fructose-bisphosphate aldolase class 2 (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase) (Fructose-bisphosphate aldolase class II) (Sedoheptulose bisphosphate aldolase) (P0AB71)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. In addition, is involved in the utilization of D-sedoheptulose 7-phosphate, an intermediate of the pentose phosphate pathway, via the sedoheptulose bisphospate bypass pathway. Catalyzes the cleavage of D-sedoheptulose 1,7-bisphosphate to glyceraldehyde 3-phosphate and erythrose 4-phosphate.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase A
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Enolase
- ATP-dependent 6-phosphofructokinase isozyme 1
- Transketolase 1
- Glucose-6-phosphate isomerase
- Fructose-bisphosphate aldolase class 1
- Fructose-1,6-bisphosphatase class 1
- Transaldolase B
Sequence:
MSKIFDFVKPGVITGDDVQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFIAGKGVKSDVPQGAAILGAISGAHHVHQMAEHYGVPVILHTDHCAKKLLPWIDGLLDAGEKHFAATGKPLFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGCTGGEEDGVDNSHMDASALYTQPEDVDYAYTELSKISPRFTIAASFGNVHGVYKPGNVVLTPTILRDSQEYVSKKHNLPHNSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEAYLQGQLGNPKGEDQPNKKYYDPRVWLRAGQTSMIARLEKAFQELNAIDVL
Protein: Type-3 glutamine synthetase (EC 6.3.1.2) (Type-3 glutamate--ammonia ligase) (Type-3 GS) (Q54WR9)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Multifunctional protein pyr1-3
- Amidophosphoribosyltransferase
- Glutamine--fructose-6-phosphate aminotransferase
- Glutamate dehydrogenase 2
- Glutamate dehydrogenase, mitochondrial
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Glutamate decarboxylase B
- Glutamate decarboxylase A
- Type-1 glutamine synthetase 2
- Type-1 glutamine synthetase 1
Sequence:
MSNRRREFIEYIDSREPVEADIDISDKADRLTDIYDSDTYGLNAMRETLPSHCYKKIREVMQTGSALDPEIADMVANGMKEWAIKQGATHYCHWFLPLNGLAAEKHDSFISIFPGDDKVLLEFSGMQLIKGEPDASSFPSGGIRSTWEARGYTVWDATSPAFIRREKNGAILCIPTAFCSWTGEALDQKTPLLRSMEYVSNESIITLSSLFNEKHKRISPTLGIEQEFFLIDRKFYLARPDLVNCGRTLIGAKPPKGQEMEDHYFGTMNSRIISCIQEVEWKMWRLGMPLKTRHNEVAPGQYEVAPIFERANIAADHNMMLMDILKNVSTKHGLVCLFHEKPFAGVNGSGKHNNWSLSTDGGSNLLEPGHTPSQNARFILFLTAIIRAVDIHADLLRASVAVPGNEHRLGANEAPPAIISIYLGKELDTVINNIINNTDIQAPGSDDMDLGVVGFPPLPKDSTDRNRTSPFAFTGNKFEFRAVGSSQVVNFPCIVLNTIVAESLRFIREEILREMKVSSRQTAFNKIIKDTLIQHVRVVFNGDGYSGDWKELAKSRGLANLPSTPEALTNINSEKNIKLFSESNILSPVELESRQEILFEIYNKSIKIEANSLYDLVSTLVLPACFAHQKNIAESVNSIMPFIQSQKSFSQPNHQYSHLSEVVESVNLLIEANQKLLALIKQTKDFNSEHSLATFLNQSVIPQMNEVRKFSDHLEGIVEDKSWPVPKYSEILFLR
Protein: Chromosome instability protein 1 (P40987)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for microtubule stability. Interacts with CIN4.
Interaction partners:
- Protein PAC2
- GTP-binding protein CIN4
- Tubulin-specific chaperone C
- Tubulin-specific chaperone A
- Tubulin-specific chaperone B
- Tubulin beta chain
- Tubulin alpha-3 chain
- Prefoldin subunit 4
- Carbonic anhydrase
- Nuclear fusion protein BIK1
Sequence:
MNNIRALLDSIQSGVQTVSPEKHQQTIAAINKFQDDPALLDTILPRCVPLLTKSFFCMSQRDQKLVAELFYNLDKISHSKVLKSLDTSIFRLNEILNYLQDRASPSSFSDVLCVYLNLSWLSVILLSPYAFKDKFNKTLQVSSRFENYPICIPPINKIKAVLYFKNFTDAFDQLPEREQANVPFLNQFLKLFIQSSEKANYYFSNENLRHLQQVALSNDGIKLLPKLFQISFNHGSHDILDAIVEFFHDHLSSNSTDTRFQLAHSFAKIAKFLHQADPASFIELIDYTIENTVSLLQAPCDSIDSNELHTSLLIIAEVALAKILPIDLVDRVLTLIIPKTCHFQKSHFQIIKGHHIRDSTNFIIWSVIRSNRSNSLSPQVLQSLLSHLLINAFFDPELIIRYSSFAALQELLGRSNKSLALNQNDIALILQANWKDLPRSFEENSGLIRRLFNPENTSKSAVCVWKVFRDWSFNWNLLENLHLTTMKLNIDYNLVPLIKSKLSSPALLQEVLNKAGSSVTQNCQILYLYLKLFENDVNCPKISEICIDIYQKKIKFQLTTQAKRQFNDNSPELFQIFVILKYWQLTGQNDFNQELFWKFVDIVSPQKKLNLYNEFIPIIQQIISQCVSLNYTRIVQLIKSDNELTCRSICHMPDQEKMCSLFFSQFPLLSPQSRSLLIGELDHHWDVRISLLPSNSYRKFRNIIINCLDDYTITQQGDVGRLVRIQALKLMQSHPDFLSGDCDSINPKLTRLLAEPVPEIRKLSYQLLASATSQITVLSDSSILNFRHKQGLSEEFWKGYAVSAGAIHFTDSQLTSSIDSFIVYYRSLSPSQQLELCHDLIRIIPSAKQIAESRIRDRNKDPLTGGMRFDTIKFTIHCVKFWTRIMESGLVVLHPNFNFQGVFAKFYNLHLLDCTTLRVSVIKFFPFLAISCYHTMRENADQKNLSNIILKRLLVLVKREYAATKSKFMTDQNVALQGMFQIFLELGVTRQLQALQVACQKHELANILESDITL
Protein: Probable glycerol-3-phosphate acyltransferase 8 (EC 2.3.1.15) (Q5XF03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Glycerol-3-phosphate acyltransferase, chloroplastic
- Glycerol-3-phosphate acyltransferase 9
- Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial
- Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 4
- 1-acyl-sn-glycerol-3-phosphate acyltransferase LPAT1, chloroplastic
- 1-acyl-sn-glycerol-3-phosphate acyltransferase 3
- Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 5
- Glycerol kinase
- Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
- Non-specific phospholipase C3
Sequence:
MSPEKKSQNFPPITECRDGEYDSIAADLDGTLLLSRSSFPYFMLVAVEAGSLLRGLILLLSLPFVIISYLFVSESLGIQILIFISFAGLKIRDIELVSRAVLPRFYAADVRKDSFEVFDKCKRKVVVTANPIVMVEAFVKDYLGGDKVLGTEIEVNPKTNRATGFVKKPGVLVGDLKRLAILKEFGNESPDLGLGDRTSDHDFMSLCKKGYMVHATKSATTIPKERLKNRIVFHDGRLAQRPTPLNAIITYLWLPFGFILSIIRVYFNLPLPERFVRYTYEMLGIHLTIRGHRPPPPSPGTLGNLYVLNHRTALDPIIVAIALGRKICCVTYSVSRLSLMLSPIPAVALTRDRATDAANMRKLLEKGDLVICPEGTTCREEYLLRFSALFAELSDRIVPVAMNCKQGMFNGTTVRGVKFWDPYFFFMNPRPSYEATFLDRLPEEMTVNGGGKTPIEVANYVQKVIGAVLGFECTELTRKDKYLLLGGNDGKVESINNTKK
Protein: Homeodomain-interacting protein kinase 3a (F6NWN5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Cellular tumor antigen p53
- Ras association domain-containing protein 5 isoform X1
- DDB1- and CUL4-associated factor 7
Sequence:
MASQVTVCPPHVYQPQTSAFCRAKKIDPSSCVYHEKIPRTYVVGVNLGIAHPTDIIPLLRFEALTSEKPCPARNFSKQTESAPQELLRRASSPYNRVASEGKLQYFSKAEVGVEEKSGDSGQNSQGSSRSSGGAPEGVRRKERSGGLNSDEGTQKCGFKCKGQEIENSKSIMQIVEEHSTLPAMLPTNVGSTTAVGVAPPEQKGTGTGAVNGTGDGDYQLVQHEVLCSMKHTYEVLEFLGRGTFGQVVKCWKRGTNEIVAVKILKNHPSYARQGQIEVSILARLSGENAEEHNLVRAFECFQHRSHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPFRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKTARFFCKESDSPYTAWRLKTTEEHEAETGLKSKEARKYIFSCLDDIGHVNLMLNMEGCDQLAEKADRREFVDLLKMMLMIDADQRIAPSDALTHPFVTMQHLMDFPHCNHVQSCFHIMDVCHLRTSIFDTLNRNKAPPLMKPVTLPSAPNITVAFNKMPSVHSQTLPPSAPPVVHPGIPIQTGSAQFGCNESFQQALILCPPAMQGIPSNPNQPAGYSVRMENTIPLVTQAPAIQPLPMRPGVIAQQPWSNRTPQILVPAWQQVPPPATSLASDTVVGAQRRGDWGKVRPHSSHYSSVMPQPIVPNQMAVSAHQPINIGIAHVVWPQPASNKRNKPSQNRSMNVSHFTDTQPSVCPSPKMPEMLPSVEPQTSSPERAVQAQVKQEPKQTEEEESCCKTTVPNKQRESIIIRESPSPAVSVISISSGTDEEEEQAQRCSLNKCKGSPECEACTGSLNMERVCSLSSPDSSLSTSSSASAQSSPSPCKRPSSISEDDGHESGCETVDGSPPSDSSLGPHESPFPERRFLRNQNQNQEPRARRGHPNNTGLNKPAVRTVVVPPMRVLNNNHHPNNEHLAISTVFESSCQSRSRCGPGRLSHLSTPTLPRQQKLSSSFQPQPLGFGQVQHYGSCHKEWNGNYRQPRRPQAFIPPTVHGPTFPLPHGSPTHSAGHPPPPALLSYPPSAPVAHLLPSPCPPPAPRPVLQPAYSLVHHQGISMGINHRLLPSPTLLPQGQFKALFPPHSYVASPAYAGFPLSPSKLSQYPYI
Protein: ATP synthase protein MI25 (ORF25) (Q00058)
Organism: Oryza sativa subsp. indica (Rice)
Function: This is one of the chains of the nonenzymatic component (CF(0) subunit) of the mitochondrial ATPase complex.
Subcellular location: Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MGLSSTDKKDRRNMLFAAIPSICASSPKKISIYNEEMIVARCFIGFLIFSRKSLGKTFKETLDGRIESIQEELQQFFNPKQVIPGESNEQQRLLRISLRICSAVVESLPTAACAPKCEKTVQALLCRNLNVKSATLLNATSSRRIRLQDDIVTGFHFSVSERFVSGSTFKASTVEQIREAFVPIDLIREGLIVLRKV
Protein: 20 kDa chaperonin (Q8IDZ8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Heat shock protein 60
- 60 kDa chaperonin
- GrpE protein homolog
- Endoplasmic reticulum chaperone GRP170
- Heat shock protein 70
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit gamma
Sequence:
MKIIFLLNIVILFLTNVLTKKHVISNTLNFINVNPKQFNNSTKRLKATEYKIDNKVIRGPLTPLNEYILIQKDEAGDTTDSGVFIGDTLKKNQYIGKVLSVGAGAINTKNGERIPIDIQVGDVVIFNPNDGNKVKYNDKECLLISNEEVLGKINDSNEINPLNITPLYDRVLIKLINPNVNSDSLIIIPESKNNDKVTDGQVVAIGNGIYDENNQKVPIDLRIDDYIKFSPFSNESCEFTYQNAKYTFVKARYVMAKY
Protein: Cell division control protein 6 homolog (AtCDC6) (AtCDC6A) (Cdc6At) (Cell division control protein 6 homolog A) (O82387)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the initiation of DNA replication. May play a role in endoreduplication. Could act as one of the factors that contributes to maintain endoreduplication competence.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- CDT1-like protein a, chloroplastic
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM3
- Origin of replication complex subunit 3
- Origin of replication complex subunit 5
- Origin of replication complex subunit 2
- CDT1-like protein b
- Minichromosome maintenance 10
Sequence:
MPAIAGPSSSPQKHVVGSRSESIGGVRSAEVNTSRKRKLISDSAAEVSATVVLPVNSISTPMKWKSPRRCAVSIPKTSDEEIKEDSNEKLENPVISVCLEVKSKWNPKDDEQMKAVKEALHVSKAPSTVVCREDEQRRVFEFVKGCMEQKKAGSLYICGCPGTGKSLSMEKVRLQAEEWAKQAGLHCPETVSVNCTSLTKSTDIFSKILGNYESGKKANGSFSPLQQLQRLFSQKQQQSRSKMMLIIADEMDYLITRDRGVLHELFMLTTLPLSRCILIGTVFCVINVHFLKSVSYGQTSFKFKVRICPPGVANAIDLADRFLPKLKSLNCKPLVVTFRAYSKDQILRILQERLVALPFVAFQSNALEICARKVSAASGDMRKALCVCRSALEILEIEVRGSIDQEPKGPVPECQVVKMDHMIAALSKTFKSPIVDTIQSLPQHQQIIVCSAAKAFRGSKKDRTIAELNKLYLEICKSSMITPAGITEFSNMCTVLNDQGILKLSLARDDKLKRVSLRVDEADITFALKEIRFFRNCLL
Protein: Peroxidase 1 (EC 1.11.1.7) (ATP11a) (Atperox P1) (P0DI10)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular location: Secreted {ECO:0000255|PROSITE-ProRule:PRU00297}.
Interaction partners:
- Monolignol oxidoreductase AtBBE-like 13
- Pollen Ole e 1 allergen and extensin family protein
- Serpin-Z10
Sequence:
MAIKNILALVVLLSVVGVSVAIPQLLDLDYYRSKCPKAEEIVRGVTVQYVSRQKTLAAKLLRMHFHDCFVRGCDGSVLLKSAKNDAERDAVPNLTLKGYEVVDAAKTALERKCPNLISCADVLALVARDAVAVIGGPWWPVPLGRRDGRISKLNDALLNLPSPFADIKTLKKNFANKGLNAKDLVVLSGGHTIGISSCALVNSRLYNFTGKGDSDPSMNPSYVRELKRKCPPTDFRTSLNMDPGSALTFDTHYFKVVAQKKGLFTSDSTLLDDIETKNYVQTQAILPPVFSSFNKDFSDSMVKLGFVQILTGKNGEIRKRCAFPN
Protein: Zinc finger protein ZIC 3 (Zinc finger protein 203) (Zinc finger protein of the cerebellum 3) (O60481)
Organism: Homo sapiens (Human)
Function: Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
Subcellular location: Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6. {ECO:0000250}.
Interaction partners:
- Homeobox protein NANOG
- Nodal homolog
- Left-right determination factor 2
- Activin receptor type-2B
- Cryptic protein
- POU domain, class 5, transcription factor 1
- Transcription factor SOX-2
- 12-
- Protein Cripto
- Transcriptional activator GLI3
Sequence:
MTMLLDGGPQFPGLGVGSFGAPRHHEMPNREPAGMGLNPFGDSTHAAAAAAAAAAFKLSPAAAHDLSSGQSSAFTPQGSGYANALGHHHHHHHHHHHTSQVPSYGGAASAAFNSTREFLFRQRSSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTDPYAAGAQFPNYSPMNMNMGVNVAAHHGPGAFFRYMRQPIKQELSCKWIDEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESSTPPAIASANSKDTTKTPSAVQTSTSHNPGLPPNFNEWYV
Protein: Tribbles homolog 3 (Zgc:76966) (Q6NY44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSMNLSTPTPPLRLKRVDFEDSHSNDTFKCKRRRLSQPPSPGLAPCLRPLSQSLEQPGSEKHHVSRIGPYILLEATEVAQTFRAVHQVTEQEYTCKVFSMKKYHEFIAPYTRLLPHSNICKISEVVLGENNVYIFFERNYGDMHSYVRTCKRLQEDEAVRLFTQMASAVAHCHENGVILRDLKLRKFVFTDQQRTKLVLQNLEDSCLLNGNDDSLTDKHGCPAYVGPEILNSRHSYSGKAADIWSLGVVLYTMLVGRYPFQDVEPTALFSKIRRGAFTVPETLSPRAKSLVYCMLRKCPSERLEAGDILLHPWLHCNNSTSLSQHSSSRHSTDQVVPDFQPSQTEDCQ
Protein: Flotillin-1 (Reggie-2) (REG-2) (Q9Z1E1)
Organism: Rattus norvegicus (Rat)
Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O75955}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75955}. Endosome {ECO:0000250|UniProtKB:O75955}. Membrane, caveola {ECO:0000250|UniProtKB:O08917}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08917}. Melanosome {ECO:0000250|UniProtKB:O75955}. Membrane raft {ECO:0000250|UniProtKB:O75955}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Membrane-associated protein of caveola. {ECO:0000250|UniProtKB:O08917, ECO:0000250|UniProtKB:O75955}.
Interaction partners:
- Flotillin-2
- CD63 antigen
- Sorbin and SH3 domain-containing protein 1
- CD81 antigen
- Stomatin
- Tumor susceptibility gene 101 protein
- CD9 antigen
- Caveolin-1
- Myocilin
- E3 ubiquitin-protein ligase CBL
Sequence:
MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQCLSEIEMAKAQRDYELKKATYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYRLERLAEAEKAQLIMQAEAEAESVRMRGEAEAFAVGARARAEAEQMAKKAEAFQMYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILSRLPESVERLTGVSISQVNHNKPLRTA
Protein: Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) (P85299)
Organism: Homo sapiens (Human)
Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
Interaction partners:
- Rapamycin-insensitive companion of mTOR
- TELO2-interacting protein 1 homolog
- Target of rapamycin complex 2 subunit MAPKAP1
- Serine/threonine-protein kinase mTOR
- Target of rapamycin complex subunit LST8
- DEP domain-containing mTOR-interacting protein
- Proline-rich protein 5-like
- Regulatory-associated protein of mTOR
- Telomere length regulation protein TEL2 homolog
- Rho GTPase-activating protein 8
Sequence:
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGRGRGSGMSDLEGSGGRQSVV
Protein: Probable transcriptional regulatory protein (P71672)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv1403c
- Uncharacterized protein Rv1405c
- HTH-type transcriptional repressor Rv2887
- Uncharacterized protein
- HTH-type transcriptional regulator LrpA
- HTH-type transcriptional regulator Rv0880
- 2-heptyl-1-hydroxyquinolin-4
Sequence:
MMPTEYPATAEESVDVITDALLTASRLLVAISAHSIAQVDENITIPQFRTLVILSNHGPINLATLATLLGVQPSATGRMVDRLVGAELIDRLPHPTSRRELLAALTKRGRDVVRQVTEHRRTEIARIVEQMAPAERHGLVRALTAFTEAGGEPDARYEIE
Protein: KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) (A0A0B4LHU7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Protein will die slowly
- Reduction in Cnn dots 1, isoform E
- GH01794p
- Non-specific lethal 1, isoform M
- Protein MBD-R2
- Histone acetyltransferase MOF
- Protein male-specific lethal-3
- Protein male-specific lethal-1
- DNA methyltransferase 1-associated protein 1
- Dosage compensation regulator mle
Sequence:
MSSFSPNQLRQCARFTGTPCTPDKEHQLREQIHSELVKIKYCANPTYECSLMRIEGYEYCIRHILRDPRSNFRQCSHVYSNGRKCINAVAKYDNKKELILTTLCFEHNRQTQLQKTHMNVGRIRSRVETNETLLHSLSSHINVEDIKPEVKKIERDDDEIDVVSPHVTPFVTQDHRNSIGHVVESSRKRRRILDYASDSSSNDADPPCLRNTAQDIEFYESDHESIDSEDDDPLKHAGVFTRAEAVKIAETKLIKLQGLYREQISYLQNVLRQRRRKYLHDIRRERELYCSIHDQLKDTPHERKLYEQLKALNSYHRRQGVEAVLYKKLKEKRARDALYAAKSSSNPKCVFTEGGVKCGERTLPCCKHCRKHILEDKRQVLFRACGVERSGVVCQEPVASILEDSSCVLHLTVAPAKRQYIQKFYEVPSTPPVESIFAAGRGLDNFVGEDPRNEPQPEGDDLLDFANGIFDFDLDGVDDLANSLDDDYSMFLDMDSDLGLAIEDDGVESDPVDLGLEEEGDGGSNDSVGPAESQAQDNLIADNFELEEPSVQDNNELNFDIDESESNVNEVLRLLEGIEHMPWFDALMN
Protein: RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1) (Q5EP37)
Organism: Influenza A virus (strain A/Vietnam/1203/2004 H5N1)
Subcellular location: Host nucleus {ECO:0000256|HAMAP-Rule:MF_04065}. Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04065}.
Interaction partners:
Sequence:
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEIFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKKSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNELTKKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
Protein: Protein KRI1 (KRR1-interacting protein 1) (P42846)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11027267, ECO:0000269|PubMed:14562095}.
Interaction partners:
- KRR1 small subunit processome component
- Nucleolar protein 6
- Multiple RNA-binding domain-containing protein 1
- U3 small nucleolar RNA-associated protein 21
- Nucleolar complex protein 2
- Ribosome biogenesis protein MAK21
- Nucleolar complex protein 14
- U3 small nucleolar RNA-associated protein MPP10
- Ribosomal RNA-processing protein 7
- H/ACA ribonucleoprotein complex subunit CBF5
Sequence:
MPRKKSAAKRAREQAKKEAAVPATDTATIKTSETSATTVKPAIEASKSYVPSEDEEEDEEEEEEEDDYGELITDEVENGINQVLDAIKNNKTDKLLDPKVKFFEDPESAAAKLANREGKHKPIYLKDYHRMNILSGDALKEDDEEYEHATVDGKQSFVSQQREEKTQLLNEIKSAFSDEENEESSGDEDDGFLKKKEPSTKKEGKNLPDPTVNEENFLEEFVNQQAWIPKKGDKVISLDLNNNEEDDEEFEDAAEKFENAYNFRYEDPNAAEIISYARSQATLRRSDDSSRRRKREEKRKIKEQIKAEKETALQKKKTKKLNKLTDILEQLTKEYGAEINADMVKKITDTLLKNDFKEEEWDNVVAELFNEEFYQQEGKPTWNEDDEIMGDFYADADGDDQTEEGEVEKEQKEEDEEEGPKRKKSKKEEKLQKKKEKRKVNELVENALEQNKLALIEEVEKEEEERKSRSRTKEEQDLKFRYREVSPESFGLTAREIFAADDTDLNEFIGLKKFAPYRSKELRAKDKRKVMKARRLREWRKKTFKNENGLAPVEAEAGEKDEDTILIPVEKASKSKHKRGHSHKHKGHQKK
Protein: D-amino acid dehydrogenase 1 (EC 1.4.99.-) (D-alanine dehydrogenase 1) (Q9HTQ0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the oxidative deamination of D-amino acids. Has very broad substrate specificity; all the D-amino acids tested can be used as the substrate except D-Glu and D-Gln. Participates in the utilization of several D-amino acids as the sole source of nitrogen, i.e. D-alanine, D-histidine, D-phenylalanine, D-serine, D-threonine, and D-valine.
Interaction partners:
- Alanine racemase, catabolic
- RidA family protein
- Histidinol-phosphate aminotransferase 1
- 3-dehydroshikimate dehydratase
- D-amino acid dehydrogenase 2
- 4-hydroxyphenylpyruvate dioxygenase
- Aromatic-amino-acid aminotransferase
- Aspartate aminotransferase
- Probable aminotransferase
- Histidinol-phosphate aminotransferase 2
Sequence:
MRVLVLGSGVIGTASAYYLARAGFEVVVVDRQDGPALETSFANAGQVSPGYASPWAAPGIPLKAMKWLLEKHAPLAIKLTSDPSQYAWMLQMLRNCTAERYAVNKERMVRLSEYSRDCLDELRAETGIAYEGRTLGTTQLFRTQAQLDAAGKDIAVLERSGVPYEVLDRDGIARVEPALAKVADKLVGALRLPNDQTGDCQLFTTRLAEMAKGLGVEFRFGQNIERLDFAGDRINGVLVNGELLTADHYVLALGSYSPQLLKPLGIKAPVYPLKGYSLTVPITNPEMAPTSTILDETYKVAITRFDQRIRVGGMAEIAGFDLSLNPRRRETLEMITTDLYPEGGDISQATFWTGLRPATPDGTPIVGATRYRNLFLNTGHGTLGWTMACGSGRYLADLMAKKRPQISTEGLDISRYSNSPENAKNAHPAPAH
Protein: Inner membrane protein YbhL (P0AAC4)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MDRFPRSDSIVQPRAGLQTYMAQVYGWMTVGLLLTAFVAWYAANSAAVMELLFTNRVFLIGLIIAQLALVIVLSAMIQKLSAGVTTMLFMLYSALTGLTLSSIFIVYTAASIASTFVVTAGMFGAMSLYGYTTKRDLSGFGNMLFMALIGIVLASLVNFWLKSEALMWAVTYIGVIVFVGLTAYDTQKLKNMGEQIDTRDTSNLRKYSILGALTLYLDFINLFLMLLRIFGNRR