wanglab/gogpt-training-data huggingface dataset:
Protein: Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7) (O95373)
Organism: Homo sapiens (Human)
Function: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9EPL8}. Nucleus {ECO:0000250|UniProtKB:Q9EPL8}. Note=Localizes to the nucleus in the presence of BMP4. {ECO:0000250|UniProtKB:Q9EPL8}.
Interaction partners:
- Importin subunit beta-1
- Transportin-1
- Ubiquitin-like protein FUBI
- GTP-binding nuclear protein Ran
- Importin-9
- Importin-5
- Nuclear pore complex protein Nup153
- Transportin-2
- Exportin-T
- Exportin-1
Sequence:
MDPNTIIEALRGTMDPALREAAERQLNEAHKSLNFVSTLLQITMSEQLDLPVRQAGVIYLKNMITQYWPDRETAPGDISPYTIPEEDRHCIRENIVEAIIHSPELIRVQLTTCIHHIIKHDYPSRWTAIVDKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLVAAMQHFLPVLKDRFIQLLSDQSDQSVLIQKQIFKIFYALVQYTLPLELINQQNLTEWIEILKTVVNRDVPNETLQVEEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNEFAEVFLKAFAVGVQQVLLKVLYQYKEKQYMAPRVLQQTLNYINQGVSHALTWKNLKPHIQGIIQDVIFPLMCYTDADEELWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTACSKRKEVLQKTMGFCYQILTEPNADPRKKDGALHMIGSLAEILLKKKIYKDQMEYMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKSDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYITPFIRPVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAHSLTCQQVSPQMWQLLPLVFEVFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYSMCKKVLTGVAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVEAALERLTREVKTSELRTMCLQVAIAALYYNPHLLLNTLENLRFPNNVEPVTNHFITQWLNDVDCFLGLHDRKMCVLGLCALIDMEQIPQVLNQVSGQILPAFILLFNGLKRAYACHAEHENDSDDDDEAEDDDETEELGSDEDDIDEDGQEYLEILAKQAGEDGDDEDWEEDDAEETALEGYSTIIDDEDNPVDEYQIFKAIFQTIQNRNPVWYQALTHGLNEEQRKQLQDIATLADQRRAAHESKMIEKHGGYKFSAPVVPSSFNFGGPAPGMN
Protein: Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform) (P48320)
Organism: Mus musculus (Mouse)
Function: Catalyzes the production of GABA.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters (By similarity). {ECO:0000250}.
Interaction partners:
- Vesicular inhibitory amino acid transporter
- Glutamate decarboxylase 1
- 4-aminobutyrate aminotransferase, mitochondrial
- Glutamine synthetase
- Glutaminase liver isoform, mitochondrial
- Glutaminase kidney isoform, mitochondrial
- Glutamate dehydrogenase 1, mitochondrial
- Vesicular glutamate transporter 1
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Alpha-aminoadipic semialdehyde dehydrogenase
Sequence:
MASPGSGFWSFGSEDGSADPENPGTARAWCQVAQKFTGGIGNKLCALLYGDSGKPAEGGGSVTSRAATGKVACTCDQKPCNCPKGDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILTHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMLIARYKMFPEVKEKGMAAVPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEVKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQSCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCLELAEYLYTIIKNREGYEMVFDGKPQHTNVCFWFVPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL
Protein: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9) (Glyceraldehyde-3-phosphate dehydrogenase [NADP(+)]) (Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase) (Triosephosphate dehydrogenase) (F4INS6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAGTGLFAEILDGEVYKYYADGEWKTSSSGKSVAIMNPATRKTQYKVQACTQEEVNAVMELAKSAQKSWAKTPLWKRAELLHKAAAILKDNKAPMAESLVKEIAKPAKDSVTEVVRSGDLISYCAEEGVRILGEGKFLLSDSFPGNDRTKYCLTSKIPLGVVLAIPPFNYPVNLAVSKIAPALIAGNSLVLKPPTQGAVSCLHMVHCFHLAGFPKGLISCITGKGSEIGDFLTMHPAVNCISFTGGDTGISISKKAGMIPLQMELGGKDACIVLDDADLDLVASNIIKGGFSYSGQRCTAVKVVLVMESVADELVEKVKAKVAKLTVGPPEENSDITAVVSESSANFIEGLVMDAKEKGATFCQEYKREGNLIWPLLLDNVRPDMRIAWEEPFGPVVPVLRINSVEEGINHCNASNFGLQGCVFTKDINKAILISDAMETGTVQINSAPARGPDHFPFQGLKDSGIGSQGVTNSINLMTKVKTTVINLPTPSYSMGDGFISRL
Protein: Dynein light chain Tctex-type 1 (T-complex testis-specific protein 1 homolog) (P63171)
Organism: Bos taurus (Bovine)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein (By similarity).
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:9677391}. Cytoplasm {ECO:0000269|PubMed:9677391}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9677391}. Note=Localizes to mitotic spindles.
Interaction partners:
- Cytoplasmic dynein 1 intermediate chain 1
- Dynein light chain roadblock-type 1
- Dynein light chain 1, cytoplasmic
- Dynein light chain roadblock-type 2
- Cytoplasmic dynein 1 heavy chain 1
- Dynein light chain 2
- Dynein light intermediate chain
- Cytoplasmic dynein 1 intermediate chain 2
- Dynein light intermediate chain
- Cytoplasmic dynein 2 intermediate chain 2
Sequence:
MEDYQAAEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKPFKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTMYCIVSAFGLSI
Protein: Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] (P11214)
Organism: Mus musculus (Mouse)
Function: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity).
Subcellular location: Secreted, extracellular space.
Interaction partners:
- Plasminogen activator inhibitor 1
- Plasminogen
- Annexin A2
- Glia-derived nexin
- Protein S100-A10
- Prolow-density lipoprotein receptor-related protein 1
- Plasminogen activator inhibitor 2, macrophage
- Vitronectin
- Alpha-2-antiplasmin
- von Willebrand factor
Sequence:
MKRELLCVLLLCGLAFPLPDQGIHGRFRRGARSYRATCRDEPTQTTYQQHQSWLRPMLRSSRVEYCRCNSGLVQCHSVPVRSCSEPRCFNGGTCQQALYFSDFVCQCPDGFVGKRCDIDTRATCFEEQGITYRGTWSTAESGAECINWNSSVLSLKPYNARRPNAIKLGLGNHNYCRNPDRDLKPWCYVFKAGKYTTEFCSTPACPKGKSEDCYVGKGVTYRGTHSLTTSQASCLPWNSIVLMGKSYTAWRTNSQALGLGRHNYCRNPDGDARPWCHVMKDRKLTWEYCDMSPCSTCGLRQYKRPQFRIKGGLYTDITSHPWQAAIFVKNKRSPGERFLCGGVLISSCWVLSAAHCFLERFPPNHLKVVLGRTYRVVPGEEEQTFEIEKYIVHEEFDDDTYDNDIALLQLRSQSKQCAQESSSVGTACLPDPNLQLPDWTECELSGYGKHEASSPFFSDRLKEAHVRLYPSSRCTSQHLFNKTVTNNMLCAGDTRSGGNQDLHDACQGDSGGPLVCMINKQMTLTGIISWGLGCGQKDVPGVYTKVTNYLDWIHDNMKQ
Protein: Killer cell lectin-like receptor 3 (5E6) (Lymphocyte antigen 49c) (Ly-49c) (Nk2.1) (T-cell surface glycoprotein Ly-49C) (Q64329)
Organism: Mus musculus (Mouse)
Function: Receptor on natural killer (NK) cells for class I MHC.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- H-2 class I histocompatibility antigen, K-B alpha chain
- H-2 class I histocompatibility antigen, D-B alpha chain
- H-2 class I histocompatibility antigen, Q10 alpha chain
- Beta-2-microglobulin
- Killer cell lectin-like receptor subfamily B member 1C
- NKG2-D type II integral membrane protein
- Natural cytotoxicity triggering receptor 1
- Natural killer cells antigen CD94
Sequence:
MSEPEVTYSTVRLHKSSGLQKLVRHEETQGPREVGNRKCSAPWQLIVKALGILCFLLLVTVAVLAVKIFQYNQHKQEINETLNHHHNCSNMQRAFNLKEEMLTNKSIDCRPSNETLEYIKREQDRWDSKTKTVLDSSRDTGRGVKYWFCYSTKCYYFIMNKTTWSGCKANCQHYSVPILKIEDEDELKFLQRHVIPENYWIGLSYDKKKKEWAWIDNGPSKLDMKIRKMNFKSRGCVFLSKARIEDIDCNIPYYCICGKKLDKFPD
Protein: Error-prone DNA polymerase (EC 2.7.7.7) (Q6M7C6)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Function: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
Interaction partners:
- DNA polymerase IV
- UmuC domain-containing protein
- Uncharacterized protein
- DNA polymerase III subunit delta
- Protein RecA
- LexA repressor
- Uncharacterized ACR
- Predicted membrane protein
- Beta sliding clamp
- DNA polymerase III subunit gamma/tau
Sequence:
MYPIIMEWNGGGSFNGRPLSWSKLERILSGKKVESLRPVLHEPDAQAPSSAMQGEASVPFAELHATSSYNFLTGASDPSDVVVQAKKLGLVALSVMDRDGFYGAVRFAEAAAEAGMHTVYGAELSLQEGVLTVLCKNPEGYKKLSHLISDAKMATGEKGEVRYPPLPMVAEHAAGDWVVLAGFQWLDKIDYVIDCFKPENIVLEFGSTMTPEDADRNEYLRRTQAKFQLRGILSTNPESAARGSVRLAGAKQALARKMPLADAESELHPMGTTWMRSGDTLLKAHPDYADLIATTVELAAECAFTLDLVAPNLPKWDTPGEHTEMSWLAHLVSTRIDTRYVGRSADIKARAATQIDYELGVIEKLGFPGYFLVVNDLVEFCRDSNILCQGRGSAANSAVCFVLGITNAEPISAGLLFERFLSPDRDGPPDIDIDIESGRREEVIQYVYEKYGRDNAAQVANVITYRTKGAMRDAARALGYPQGAADAWAKGTSEPPDDVLELAAQFKGQPRHLGIHSGGMVICDRPIADVVPVEWARMDNRSVVQWDKDDCATAGLVKFDLLGLGMLEAIHHMLDLVAEHRGKKINLWELDLAEPEVYDMLCKADAVGVFQVESRAQLSTLPRLKPRTFFDLVVEVALIRPGPIQGGSVHPYLRRRAGEEAITYDHPVLEKSLGKTLGIPLFQEQLMQVAVDAAGFSGGEADSLRRAMGSKRSPERMAALRSRFFQGLKDTNGIVGETAEKLWNKIVAFAAYGFPESHSQSFASLVYFSAWFKYHYPAEFCVGLLRAQPMGFYSPQSLISDARRHGVSILPITVNDSGVEADAPNGAIRLGLNLVKGLGHDAAQRIEDNAPFDSIPDLSRRADLNVAQVEALARAGAVDCLGVGRRQALWQAGVAATEKPGMLPGLSVIEAPALPGMSAFELMATNISATGVTADYQPMALIRERMEELGIVPADRLLEVEDGTRLRIAGIVTHRQRPQTASGLTFLGMEDETGLMNVMVSVGLWQRQRVLARNAKALIIRGIVQNAQGVATVVADRLEPLDMGEFLSRGSRDFR
Protein: Actin-related protein 8 (Q8R2S9)
Organism: Mus musculus (Mouse)
Function: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Specifically localizes to mitotic chromosomes. {ECO:0000250}.
Interaction partners:
- Actin-related protein 5
- INO80 complex subunit C
- RuvB-like 1
- RuvB-like 2
- Actin-like protein 6A
- Nuclear factor related to kappa-B-binding protein
- INO80 complex subunit E
- TCF3 fusion partner homolog
- Chromatin-remodeling ATPase INO80
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
Sequence:
MTQAEKGDAENGKEKGGEKEKEQRGVKRPIVPALVPESLQEQIQSNFIVVIHPGSTTLRLGRATDTLPVSVPHVIARRHKQQGQPLYKDNWLLREGLNKPESNEQRQNGLKMVDQAIWSKKMSNGTRRIPVSPEQTRSYNKQMRPAILDHCSGNKWTNTSQQPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHPGPGGSLTAVLADIEVIWSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVHMILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPMALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQSSDLPERLHSQEVDLASSQGDCLMAGNESEEALTALMSRKTAISLFEGKALGLDKAILHSVDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRERAAFVW
Protein: Echinoid, isoform A (Echinoid, isoform B) (Q9VQW7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Canoe, isoform E
- Actin-5C
- Bazooka, isoform B
- Epidermal growth factor receptor
- Transcriptional coactivator yorkie
- Protein crumbs
- Friend of echinoid, isoform H
- DE-cadherin
- Neurogenic locus protein delta
Sequence:
MRRKTTTKGTAIVNSRSARRAATTICNFFLIALVALSSTTLADESIDTRENADLTLKCRFNDKYEANDFSFFWTRWTANPAQFDNVAIGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAKGTGADVHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNEVNSANSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKALNPKSDSPYSSEIMVTTKVSRIPPPLQVTYEPNTRTLGIDVGATCLNLVAVVESMVNADSPMAAWEVVTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGRALGHTISEDEDDNGLNSLALEDENSPTVRVKLCLRTNPEHCGDYTDAEIGRPYIAEANALATPTLIAIIVSCVVFALFAGLILMFCRCKRNQSKKSAAAKDYEMDSVRPSIVAAQQNQAPPPYYPASGLDNKALEHSMDLALSMEDQKTALYATQNGYSYHPGSGVVGVGMGGGVVGVGVGGSVVSGMGGGVGGIGGSGVGVNGIPGLSAHTMPGNEWVNMGYMENNYSNSNNGGSVNSQDSLWQVKMSAAAVGNQQGMVQAPMNQYVEQQPAYGYDPLTHGGYGAVDDYAPYPHLTATPSQVGDEYHNLRNSQNPSRQDYCSDPYASVQKPKKRVDQHLDSPYHDVSGLPNPYNMEHLEQDEVLPPQQHMSLSYDDSFEGEYSTTPNARNRRVIREIIV
Protein: GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) (Q9R1S3)
Organism: Mus musculus (Mouse)
Function: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. May act as suppressor of replication stress and chromosome missegregation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10574991}; Multi-pass membrane protein {ECO:0000269|PubMed:10574991}.
Interaction partners:
- GPI alpha-1,2-mannosyltransferase 3
- GPI alpha-1,6-mannosyltransferase 2
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
- FYVE, RhoGEF and PH domain-containing protein 4
- GPI alpha-1,4-mannosyltransferase I, catalytic subunit
- N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
- GPI-anchor transamidase
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
- GPI ethanolamine phosphate transferase 3, catalytic subunit
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
Sequence:
MLLFFALGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTLYELDEDGNSRAPFIRNVIIHEGSWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPSSREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTWGAGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGILPVGYLNNTGLFKAESMFTNAVQILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLDILRKARSYIKQEKFDEVVSLCEELIDLALRGLSYYHTYDRLFLGINVAVGFVGWMSYTSLLIIKSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMIQACPWTYYVYCLLPVPIWYAVLREHEVIQDLVESLLTFPRSHFVAYLLVFTLGIEVLVLSFFYRYMLTAGLIVFAGWPFLTQLWTRAKITFLSWAFFSLLLAVFPLMPVVGRKPNLSLVMGAGFLVLLLSLAVVTTLGKRNIKLVKGELLVLLLQMLSTVLSMYVVYSTHHSLLKKEGLPLMNQIVSWATLASSLVAPLLSSTALSQRLASILLSLMSTYLLLSTGYEALFPLVLSCLMFVWIQVEQETLQQPGVSCKQKLTSIQFTCDTDIAQFRQLCPDDIRRAFFLVFFLLTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQITTQLSSKGLFLVVLIISDIMALHFFFLVKDSGSWLDIGTSISHYVIVMSMTIFLVFLNGLAQLLTTKKLQLCGKPKSHLM
Protein: High mobility group protein B2 (High mobility group protein 2) (HMG-2) (P17741)
Organism: Sus scrofa (Pig)
Function: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity. May play a role in germ cell differentiation. Involved in modulation of neurogenesis probably by regulation of neural stem proliferation. Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P26583, ECO:0000255|PROSITE-ProRule:PRU00267}. Chromosome {ECO:0000250|UniProtKB:P26583}. Cytoplasm {ECO:0000250|UniProtKB:P26583, ECO:0000250|UniProtKB:P30681}. Secreted {ECO:0000250|UniProtKB:P26583}.
Interaction partners:
- Membrane progestin receptor alpha
Sequence:
MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKGEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEDEDEEEEDEDEE
Protein: Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (B3DHM6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early endosome {ECO:0000256|ARBA:ARBA00004412}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Uncharacterized protein.
- Adrenoceptor beta 3a
- Adrenoceptor beta 2, surface a.
Sequence:
MGDGLPSVNYSNDSKRATVDLNVSEQWLVGMGILMGLIVFVIVVGNILVIVAIARNQRLQTLTNVFIVSLACADLIMGLLVVPFGAALEVRGAWMYGSFFCEFWISLDVLCVTASIETLCVIAIDRYIAIISPFRYQSLLTKARAKVVVCAVWAISALVSFPPILMHWSQDSEETSCYENPECCDFVTNRAYAISSSIISFYIPLIVMIFVYARVYREAKQQLNKINKCEGRFYNNHGTNCKPTRKRTTKILALKEQKALKTLGIIMGTFTLCWLPFFIVNVVRVFCAQVVDKELFVFLNWLGYVNSAFNPIIYCRSPDFRKAFKRLLCCPRQADRRLHVSSCDLSRCTGGFGNSMEQSMLGTWSDCNGADSSDCSLERNGRMSHSESQL
Protein: Protein FMP49, mitochondrial (Found in mitochondrial proteome protein 49) (A0A023PZB3)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14576278}.
Interaction partners:
Sequence:
MYYFSRVAARTFCCCIFFCLATAYSRPDRNPRKIEKKDKKFFGASKNTNPANAMGNLFKAPTIEYVVEEVTRTHQPEQYDIPTDMSPLMTIAASESADKFTDKFFVDQSSIMKEKTSSKGNARTLL
Protein: Transmembrane ascorbate ferrireductase 2 (EC 7.2.1.3) (Cytochrome b561-1) (Artb561-2) (AtCytb561) (Protein b561A.tha4) (Q9SWS1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Two-heme-containing cytochrome. Catalyzes ascorbate-dependent transmembrane ferric-chelate reduction (Probable).
Subcellular location: Membrane {ECO:0000305|PubMed:24449903}; Multi-pass membrane protein {ECO:0000305|PubMed:24449903}.
Interaction partners:
- Cytochrome b561 and DOMON domain-containing protein At3g07570
- Actin cross-linking protein
- NADH-cytochrome b5 reductase-like protein
- Electron carrier/ protein disulfide oxidoreductase
- At1g80480
- Mitotic-spindle organizing protein 1A
Sequence:
MAVPVLGGFPIFMVVRVLGFIIAALVLTWTVHYRGGLALSSDNKDHIFNVHPVMMVIGLILFNGEAMLAYKSVQGTKNLKKLVHLTLQLTAFILSLIGVWAALKFHIDKGIENFYSLHSWLGLACLFLFAFQWAAGFVTYWYPGGSRNSRASLMPWHVFLGISIYALALVTATTGILEKVTFLQVNQVITRYSTEAMLVNTMGVLILILGGFVILGVVTPVSGKDQVLTQ
Protein: Cyclase-associated protein (Q8I288)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Cofilin/actin-depolymerizing factor homolog 2
- Cofilin/actin-depolymerizing factor homolog 1
- Oocyst capsule protein
- Actin-like protein, putative
Sequence:
MTSEGSIQLKDDQWDVINYKDGKIVKLSQVELNNAVNIYNCENTTFVIENNKFKSLQIEKCVKCNVVLNNLISSIEIINSKKVKIQVLGKSSSISIDKCTGVEFYLSKENVECEFTTALSSEMNIHIQGQDEEWTEITIPEQFQHHLENGKLTTRVSDLYKF
Protein: Major prion protein (PrP) (Major scrapie-associated fibril protein 1) (CD antigen CD230) (P10279)
Organism: Bos taurus (Bovine)
Function: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P04156}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P04156}. Golgi apparatus {ECO:0000250|UniProtKB:P04925}. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis. {ECO:0000250|UniProtKB:P04156}.
Interaction partners:
- Amyloid-beta precursor protein
- Alpha-synuclein
- Presenilin-1
- Islet amyloid polypeptide
- Prion-like protein doppel
- Small ribosomal subunit protein uS2
- Huntingtin
- Microtubule-associated protein
- Tyrosine-protein kinase Fyn
- Pancreatic trypsin inhibitor
Sequence:
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
Protein: H-2 class I histocompatibility antigen, D-37 alpha chain (P06339)
Organism: Mus musculus (Mouse)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Natural killer cells antigen CD94
- Killer cell lectin-like receptor subfamily C, member 1
- Beta-2-microglobulin
- Tapasin
- H-2 class II histocompatibility antigen, A-B alpha chain
- H-2 class I histocompatibility antigen, K-B alpha chain
- Class II histocompatibility antigen, M alpha chain
- Histocompatibility 2, M region locus 3
- H-2 class II histocompatibility antigen gamma chain
- Antigen peptide transporter 1
Sequence:
MLLFAHLLQLLVSATVPTQSSPHSLRYFTTAVSRPGLGEPRFIIVGYVDDTQFVRFDSDAENPRMEPRARWIEQEGPEYWERETWKARDMGRNFRVNLRTLLGYYNQSNDESHTLQWMYGCDVGPDGRLLRGYCQEAYDGQDYISLNEDLRSWTANDIASQISKHKSEAVDEAHQQRAYLQGPCVEWLHRYLRLGNETLQRSDPPKAHVTHHPRSEDEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPLGKEQYYTCHVYHEGLPEPLTLRWEPPPSTVSNMVIIAVLVVLGAVIILGAVVAFVMKRRRHIGVKGCYAHVLGSKSFQTSDWPQKA