Protein: Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) (E1C2U2)
Organism: Gallus gallus (Chicken)
Function: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM-phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6PR54}. Chromosome {ECO:0000250|UniProtKB:Q6PR54}. Chromosome, telomere {ECO:0000250|UniProtKB:Q6PR54}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q5UIP0}. Note=Following interaction with TP53BP1, recruited to sites of DNA damage, such as double-strand DNA breaks (DSBs). {ECO:0000250|UniProtKB:Q5UIP0, ECO:0000250|UniProtKB:Q6PR54}.
Interaction partners:
- PAX interacting protein 1.
- Shieldin complex subunit 2.
- Tumor protein p53 binding protein 1.
- Uncharacterized protein.
- Non-specific serine/threonine protein kinase.
- Uncharacterized protein.
- Shieldin complex subunit 1.
- Uncharacterized protein.
- Shieldin complex subunit 3
- E3 ubiquitin-protein ligase RNF168
Sequence:
MSGTVSAAAGLRPLLETLQDPAAPAGDLTDAHLSLVNRLSGEEGREFVAAVRKHFPRLCKVFKAHISSENSELSNAALQALGFCVFNSKITSELSASEVEDLLSTLNSIAVKTSDKNTRTRALWVISKQTFPSEIIKKEVSSLISTLETILTKGDVQSMIVEYEALNVVIRLMEQAPAQMGEEAVRWAKLIIPLVVHSAHKVQLRGATALEIGMPLLLQKQQEVAAVTEHLMTTKLISELQKLFSTKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELGFRSGSPVVKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTEALALTKLEVWWYLLMRLGPQLPANFEQVCIPLIQSTLSVDSAAALQGTPSRVPSNPNSANPPQKPGPYPFASPATPRMNLNSSTAGLVAIPSIQLLGIEMLLHFLMGPEVLEFAKRNKLVLSLEPLQHPLISSPSFFCKHASTFINAVQDGFIAVGKEVPESMLNSIWKDINGHVKAAIESGNKKEKQGSEVLTMLLQALKNIVRSNSLPVQKILSLIDITVKELPPKVLGSPAYQIADMDLLNGTPALFLVQLPFHNNLLEWCVTDERFFIILETLMRYVLSGPTSLLAFSESVLCVINQNAKQVENKEHLWRMWSIVVNPLTDWINRTNEVNQGDALEHNFNAVYNALLLPVSHIFPVQEFPQPTMKSLLRAWSDLYRAFARCAALVATAEENLCCEELCAKIISGLEGETPVMSAMLDGLTHVVAVMVDCINFAPYGTKYQPKNRSPQTPTDWSKKKREPLGKLSSLFKLLVMLLDSFHALSSEETCPEPLASVGHSLIAVLHNIISHVSLPSMIGTMFAVFSKPLAVFYEKTKLADVPKAYSNLNSKLEKLLAEIILCLQSHCMGCYDSELLEQLSPLLCVIFQHKSKQMRKQCANFWNTTFAKAASLTYPEELKPVLSQAKQKMPLLLPGFESIEIADEQSGPFSDEAENSQWDAKLSGMEVNLGQKRDSILAQTGELKNEVKDKSDNVQVTSAKLKLEFSASKPKSDVLLEEEKSVDFVFIPPETKARILTEHQKEVLRSKRVGIPAMYNNLDSSQDTTLFSQYTQSQEDSLEKSPLENAKEDFKNNPQEENGKSESCIADSDGNTGDCKVDNPLEDVKEKSAYHIEKNSNSEEESSRGDRTGIIGEESSVGEALEKSGTETASKESLVGNENTSAISCSSTSSDVICGTPQPASRRQSFITLEKFDSSESRPFSPSALNSVSEVSQSAPVPDKQGNINVCKTGRKPGKSGEESRKSSQSEQISAAKRRLTRRQSKMEQQGNQQAKLVTNSEQEKGAQESFVSNSVENSPESPCSMEDTERVLTAQPQPVSSPEPDIKKAEAVMAEIEKVRAFEMDSKENTPPKTAVSSEQVMGDGSQGPHASLSQKTLRRSSRRRSENAEMAAGSQDKEDGYQKKDKRKEDEKALQKKVPQTKEDASQKQKAVCGKASEHAIKKESSLPERSAAEDLGSKEPPAAKGADEEANRSAGKPEDTLKSDSEGQDCSSDTVSEKKRERPRYHTRRSSQGLLSSIENAEADGSETKKESLKKKSGKTKNKSDSLEGKRKDVQPESQSHGVSSQVDESKNLSGMNESELSSEVSTDAALMSAPSDVKNQVLLAGADEAEGSASSRTSPSTQNVSVEQSKAGVLPESFSDPRVSDEVLKGDENKCIEKQSSVEQHSSVQPENVQGANTSGSDLSSLQMQDCQHKRSKRVRKAKSCDCCSKRVKQQTSLSESKSEDPRELIEPQATPVQMAVSTAEVSGSSNLEESLSITPCAMSTPLPPAKESGMLSLERERTGEDNLQGNSGVMKEEAENPAHTAGEVSDPVVEIKVKEEVDGNDRAEQCVSVSECASDEPSDSSVAAGDQSEEKAAVEKEEESQHGEMEEVPEADGSKPETKQMDELEGNRDGKEEAENALEEVCITPDNEMREELLEAEITVPENVAVGNKDVVVENKSADSPQKPEGLDSFTSVNGSPSGVQARCTWSPSASPSTSILKRGVKRHHEDDSLSPANKIRRVSFANPIYQEGLADDIDRRSPVIRSHSSPSSRSLKILSNIQTKHITTPTKGFLSPGSRNPKFKSSKKCLMTEMVKESLPSPTECVYPALAGCKAPVDVILPQITSNICARGLGQLIRAKNIKTVGDLSALTASEIKTLPIRSPKVSNVKKALRGYHEQQVKSRGCEEIGALEDGERTVNSAEDKSPPVDEEKLATDLGEAIALSSSSPPPADLLSQMDLLAAQLTSEDLRSYPGSRLFEMQEKLASMSDCIMKTLRSRWRSPPHDSAE