wanglab/gogpt-training-data huggingface dataset:
Protein: Large ribosomal subunit protein uL13 (60S ribosomal protein L13a) (Transplantation antigen P198) (Tum-P198 antigen) (P19253)
Organism: Mus musculus (Mouse)
Function: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). Involved in methylation of rRNA (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}.
Interaction partners:
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL19
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL14
Sequence:
MAEGQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALERLKVLDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKMHYRKKKQILRLRKQAEKNVEKKICKFTEVLKTNGLLV
Protein: Testis-specific Plus3 domain b (Q8IME7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Ctr9, isoform A
- RNA polymerase II-associated factor 1 homolog
- Transcription elongation factor SPT5
- Transcription elongation factor SPT6
- FACT complex subunit spt16
- FACT complex subunit Ssrp1
- Transcription elongation factor SPT4
- Hyrax
- Uncharacterized protein
- FI06213p
Sequence:
MDERLRTRRKIANKLESGGKTAHAFERLLAIRTIKLSKGKCSEDSAEQTKSSDDCKAQTRKDVNIEVKETYSGDSSPNSESENTAQNDPQMNVESEERVSNLEQLSRAVLKRNDIKNLLGKPIFAEAVIGSFVRLNVGKVYSIYETIALHQDSKDYRVDGKRTNLILVLRCGSEKRYSRIDVVSNQPITQKEFLLWLETNLRNRCTLPTLNDIAKKQVQVKNACKYSYTETDVEKLIQDKKEAGIKQNAAYRKISLIIERDMAAGMNDVEKVQVLEKKILEIDEEPRPQIEKTGQHRYQVLSSTRGVHVPTIYRHELGVPSGGKSSFVKRTAKPEQHELEKYMRRKYKKSAVVSRSRFKKAFEDCVDSSAMVNDIHMESQQKEGDVETETETEKGTEKDLHSQRLHTFNIELDTTGLVPFHEIFPNVKFNSPWDEIMKG
Protein: Protein HMF1 (High dosage growth inhibitor) (Homologous mitochondrial matrix factor 1) (P40037)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm. Nucleus. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}.
Interaction partners:
- Diphthine--ammonia ligase
- Diphthine methyl ester synthase
Sequence:
MVTTLTPVICESAPAAAASYSHAMKVNNLIFLSGQIPVTPDNKLVEGSIADKAEQVIQNIKNVLEASNSSLDRVVKVNIFLADINHFAEFNSVYAKYFNTHKPARSCVAVAALPLGVDMEMEAIAAERD
Protein: Elongation factor 1-delta 2 (EF-1-delta 2) (Elongation factor 1B-beta 2) (eEF-1B beta 2) (Q9SI20)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
Interaction partners:
- Probable elongation factor 1-gamma 2
- Probable elongation factor 1-gamma 1
- Phenylalanine--tRNA ligase beta subunit, cytoplasmic
- Elongation factor 1-alpha 1
- Translationally-controlled tumor protein 1
- Translationally controlled tumor protein 2
- Elongation factor 1-beta 2
- Elongation factor 1-beta 1
- Large ribosomal subunit protein uL11x
- 60S acidic ribosomal protein family
Sequence:
MAAFPNLNSGSGLKKLDEHLLTRSYITGYQASKDDITVFTALSKPPTSEFVNVSRWFNHIDALLRISGVSAEGSGVIVEGSSPITEEAVATPPAADSKDTAAEEEDDDDVDLFGEETEEEKKAAEERAASVKASTKKKESGKSSVLMDIKPWDDETDMKKLEEAVRSIQMEGLFWGASKLVPVGYGIKKLHIMCTIVDDLVSIDTMIEEQLTVEPINEYVQSCDIVAFNKI
Protein: G protein signaling modulator 1 (A0A0A0MSK4)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAGPAPPAADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRVHVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEPQQQCQPGAS
Protein: Pheromone-regulated membrane protein 8 (DUP240 protein PRM8) (Protein DUP1) (P53174)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in endoplasmic reticulum exit trafficking of proteins.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:12101299, ECO:0000269|PubMed:12925749}.
Interaction partners:
- Putative uncharacterized protein YGL052W
Sequence:
MQTPSENTNAKSDSLDEPGAYLIEENVALPKDIFHSYLSYWIYEAAHCTPVMLLSLVIGVLISIIILFHDNENCVGVSVGFLLIFSGILVIVLILRFGPQISDEDFKCKLLMEIITRKPTVKGKEWRTITYKMNQYLFDNDLWNTPYYFYRDEDCHRYFLSLIKGRTFKKQKESSASNVKDAQSNDETAGTPNEAAESSSFSAGPNFIKLLTKAAEIEQQFQKEYWRQEYPGVDEFF
Protein: Pickpocket 23, isoform D (M9PHF4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPQEKRHPPESRTQRFLETLVIFRRSLIYQTKEFFQNSTLHGVRYIAESGRPIGEKFMWFCFTSIGAVTALVIIMSLWEKFQTNPTITGLDTDFHNQNVVFPTTVVCPEAAFDHDKTYEKVYNTLANYDEAQAQMYTPFLRILTSLNFENVRDAKVLSQSIPQNLLDAHTIREWAFEGHIDCKNVFVSCKYRDEDIPCCDHFEPIYTEHGFCYAFNSRFKSTPTEDVKTGAPHDLYETDKKWALFFIPNSTSRIFIFSNEEYFGSDFNAQIDWSEPQLVEVRISKKNTYTTDDARQLSIGQRKCIFSDEVKLNYFPDAYTFSSCMKQCRMNKAIKLCKCNPPFYKPIPNVPMCSIKDFDCLDEFKSNITNIKDCLQCELSCSKTVFNIDKLIKMSDRPESLGVLVEFLTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEIIYYFTLRACCMVYKNRQELYEIEEKIRQEPPPKIDLKLSLKSHNPRIGDTPTSAVLKVKPAEESAGPNPLGGYQRKHEKDYSLNTKNYYKTPKVVPDYGYTSKTKNSWTTYDHSQYMP
Protein: Stevor (Q9U5M0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKMYNLKMLLFTFLINTLALPHYDNYQNSHYNINLIQYRAQRTTINSRLLAQTKNHNPHYHNDPELKEIIDKMNEEAIKKYQQTHDPYKQLKDVVEKNGTKYTGGKDAEPMSTLEKELLETYEEMFGNESDMLKSGMSPNVDEKSSTCECTDINGVKLAKTKGRDKYLKHLKHRCIGGICSCSVGSFLLTMFGLHAAKVAAVAAVLSTYGKTSTCSSVLSITNMFNPATLQSVLCATNGCTIGASDVVLPATSAAMGTFQPCGIAALVLLILAVVLIILYIWLYRRRKNSWKHECKKHLCK
Protein: Uncharacterized protein (A0A1S4H521)
Organism: Anopheles gambiae (African malaria mosquito)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MCHPLVVMPWYVRILVVISLLGSSWGVLVVGPKFVRSNQEYALVISNFNSGSSKVNLMLHMEGFSKNQTSVFAIRKPVDVRRFMSRIVSFDIPNIASPVDIKLTMVGQRGFSFHEEEHLVHRSKSISGLIQIDKPVFRPGDLVKFRAIVLDTELKPPARIKSVNVTIQDPHQNKIRGWPAAKLYAGVFENDLQLAPAPLLGVWNITVQVGEEQLVFKTFEVKEYVLTSYDVQVMPSVMPLVEHQTLNLTIVANYHFGKPVQGVAKVELYLVDDTLDQKKELTMYGMGQVELRFNELLELYEDQQDVRVKLTFTEQHTNRTVVKEQAITVYKHPYRAQLTKESPQFRPGTPFKCTLTLIYHDGRPAGHVPFFVNVEGEDVDHQQTYTTGRDGTIKLLMRPTELTETIDITVSEDNSEFTYTERIEKVHADTNVFLKLELKSPIKLGKLIRLMVTCNERMTFFIYYVISKGNIVDAGFVRPNRQTKFMFQLTASEKMIPKAYIFVATVSQDVVVWDSLEIDLKQFSNHLDIIIDEKELKPGQEIELLLKGRPSAYVGLAAYDKGLLAYSKQHDLFWEDVMQVFDTFHATDQNEFDVFNSMGLFARLSGGNRIGASPTTTERFGSAASRPISRLVAYRTNFLESWLWQNVSIGRTGSRTVHEVLPDTTTSWYLTGFSIDPVYGLGIIKKPIEFITVKPFYIVDSLPYSIKRGEAAVLQFTLFNNLEAEYIADVTLYNVANQTEFIERPDKDLSYTKSVSVPPKVGVPISFGVKARKLGEMVVRIKASIMTGKETDAMEKVIRVIPENIMFEKTETRFFSMDEYGKQEFNMQLDIPKNISTVQIKCRISSNLLSPVIHNLDSLLDVPSASGAPSMINFIPPLVVLDYLKAVSSTTTHLIEKATGLLRNGYQLELKYRQRDGSFGNWRDSKGSVFVTALVGTSLEAASKHITEVDLTLVDRLFEWLAAKQHSSGRFDEEQPITYYSLQGGSRNGIALTSFVLIAFLQNTKASAQHRSIIEKGIQYVANQLESIADVYDLSLATYALMLADHRQKSSALNKLIELGIATNETRYWPRDTASIETTAYALLSLVHAKRYADGLMVMHWLVNQQSATGSFPRTQDTFVGIRALAALSEAIAPQKNDYTAIVLHGKARKVYKVAASEADQEYHDVLPGDSKLVRFSANGRGFGMFTVAFQYGIDVRNIEHGFSLRLVDQFSNEAYTLQLQVCTSFSPQLMHTRSNLALVEVNFPSGYVVSRKSLVDETRRNPFKDVEVRYGQTSLVIYYETLGPEENCFSVTANRLFRVAFHRQAYVMVHDTYDEKFRAIKFYQVPHDGADIQSYLD
Protein: Oxidation resistance protein 1 (Q7KTR8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MWFAISLFAILAVCGLAGRRWGRYLYLHYGRHLLPRSLLSAKNRAPTPPLSPTKDDQSLEALLDESGEMHETVLSMSTDEYRKTSLFATGSFDLDFPIPDLIGKTEILTEEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIVIEDTEHNVFGALTSCSLHVSDHFYGTGESLLYKFNPSFKVFHWTGENMYFIKGNMESLSIGAGDGRFGLWLDGDLNQGRSQQCSTYGNEPLAPQEDFVIKTLECWAFV
Protein: Candida glabrata strain CBS138 chromosome K complete sequence (Q6FMR2)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome H complete sequence
- Candida glabrata strain CBS138 chromosome I complete sequence
- Candida glabrata strain CBS138 chromosome I complete sequence
- Candida glabrata strain CBS138 chromosome I complete sequence
- ATP synthase subunit beta
- Candida glabrata strain CBS138 chromosome G complete sequence
- T-complex protein 1 subunit alpha
- GrpE protein homolog
- Endoplasmic reticulum chaperone BiP
- CCT-theta
Sequence:
MLRAVARSQVRSLRNARLYSSFKELKFGVEGRAALLRGVETLADAVSATLGPKGRNVLIEQPFGAPKITKDGVTVARSITLEDKFENMGAKLLQEVASKTNEAAGDGTTSATVLGRAIFTESVKNVAAGCNPMDLRRGSQAAVEKVIQFLTENKKEITTSEEIAQVATISANGDAHVGKLLASAMEKVGKEGVITIREGRTLEDELEVTEGMRFDRGFISPYFITDAKSGKVEFEKPLLLLSEKKISSIQDILPALELSNQSRRPLLIIAEDVDGEALAACILNKLRGQVKVCAVKAPGFGDNRKNILGDVAILTGSTVFTEELDLKPEQATMEHLGSCDSITITKEDTVILNGNGSKDSIQERIEQIKNSIDVTTTNSYEKEKLQERLAKLSGGVAVIRVGGASEVEVGEKKDRYDDALNATRAAVEEGILPGGGTALVKASRVLDEVKTENFDQKLGVDIIRKAITRPAKQIIENAGEEGSVIVGKLVDEFGEDFAKGYDSAKGEFTDMLAAGIIDPFKVVRSGLVDASGVASLLATTEVAIVDAPEPAPAAGAPGGGMPGMPGMM
Protein: Meru, isoform A (Meru, isoform C) (Q9VUU9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- FI07216p
- Zinc finger protein 706
- GH01133p
Sequence:
MAPQQQNSTFIDDNLDSCPSLLNLPESPILPPRRCQNQDTNNNNNNNKQAAFEERLVDESPSVGEPPLAPPIPLAIPMAPAPPHRQACKNKHGRENGNAGQASRRHRSISLYGVNSTVEQGHKEIPIWMDDGEARYVSGVTNKTTCDDIIKALIDDELRNGNGFYCGNNPKDGGQRKTAAASRDYSDYIITESWGGIERCYDGNMAILPVWRAWSRVHNELRISLKHRDSFRDPLAMQLVPHSQSATGFSMYKWLKKLLHLKKGKKTPPKPTKTPPKVPNKLKEKRVHGQKQTMTNDLVLVIMPDQLYRGTENTAKSKLYKLAENRVSKQRHRRRSRHEITKASVETFRTAIPSECNNNNYNVNNCIRRRKDKPLRNSVRYKLASLHADMNVRYEKEHALTRQLSEMCRLYRLQNERYKGPEMELSVGQLQQNIEAYAEDIIKTEHELLELKNEIKHDISLINNLKRLTLEESEADAACKKGAAKITHPLQENENTPQVAKNTQEMQFVDNIYEFCDNNASMLV
Protein: Serine/arginine-rich splicing factor 2 (Protein PR264) (Putative myelin regulatory factor 1) (MRF-1) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) (Q62093)
Organism: Mus musculus (Mouse)
Function: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA (By similarity). Can bind to the myelin basic protein (MBP) gene MB3 regulatory region and increase transcription of the mbp promoter in cells derived from the CNS. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear speckle to nucleoplasm. {ECO:0000250}.
Interaction partners:
- Serine/arginine-rich splicing factor 1
- Serine/arginine-rich splicing factor 3
- Splicing factor U2AF 35 kDa subunit
- Splicing factor U2AF 65 kDa subunit
- Serine/arginine-rich splicing factor 9
- SRSF protein kinase 1
- Serine/arginine-rich splicing factor 7
- Transformer-2 protein homolog beta
- Heterogeneous nuclear ribonucleoprotein H
- U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
Sequence:
MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSRRGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRSTSKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRSKSPPKSPEEEGAVSS
Protein: At2g44010 (O80571)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT4g26130/F20B18_240
- At5g11810
- F19P19.27 protein
- ARM repeat superfamily protein
- At5g26800
- non-specific serine/threonine protein kinase
Sequence:
MDGLIPMALKAVKKNLTRRRYERLSYSATTRESYDFASDIEMNVDGRHHRRGWSVGDFSSLSSRETKRNGGVAPEKSLTPPREGQLVRFKSHRLFSCISGQ
Protein: Protein polybromo-1 (BRG1-associated factor 180) (BAF180) (Q8BSQ9)
Organism: Mus musculus (Mouse)
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- Bromodomain-containing protein 7
- AT-rich interactive domain-containing protein 1A
- PHD finger protein 10
- AT-rich interactive domain-containing protein 2
- SWI/SNF complex subunit SMARCC2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- AT-rich interactive domain-containing protein 1B
- SWI/SNF complex subunit SMARCC1
Sequence:
MGSKRRRATSPSSSVSGDFDDGHHSVPTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKAYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTLADGSSPGYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMTKSSLRIRTASNLAAARLTGPSHNKSSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFHQLYDTVRSCRNHQGQLIAEPFFHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMMEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKDKRKELGPLPDDDDMASPKLKLSRKSGVSPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNSPNKPPLTFDIIRKNVESNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIRIRDELCKNGEILLSPALSYTTKHLHNDVEKEKKEKLPKEIEEDKLKREEEKREAEKSEDSSGTTGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSDDNRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLRYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMSCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIIPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEAPSLPQLQTPLANELDLMPYTPPQSTPKSAKGSAKKESSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQAYNLENV
Protein: Replication factor A protein 3 (RF-A) (Replication protein A 13 kDa subunit) (P26755)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism (By similarity). Stimulates the activity of a cognate strand exchange protein (SEP1).
Subcellular location: Nucleus.
Interaction partners:
- Replication factor A protein 1
- Replication factor A protein 2
- DNA polymerase alpha subunit B
- DNA primase large subunit
- DNA primase small subunit
- DNA polymerase alpha catalytic subunit A
- DNA repair and recombination protein RAD52
- DNA polymerase delta catalytic subunit
- DNA polymerase delta subunit 3
- DNA polymerase delta small subunit
Sequence:
MASETPRVDPTEISNVNAPVFRIIAQIKSQPTESQLILQSPTISSKNGSEVEMITLNNIRVSMNKTFEIDSWYEFVCRNNDDGELGFLILDAVLCKFKENEDLSLNGVVALQRLCKKYPEIY
Protein: Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) (O14964)
Organism: Homo sapiens (Human)
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9JJ50}. Early endosome membrane {ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q9JJ50}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ50}. Note=Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments. {ECO:0000269|PubMed:16159959}.
Interaction partners:
- Signal transducing adapter molecule 1
- Tumor susceptibility gene 101 protein
- Signal transducing adapter molecule 2
- Heparanase
- Polyubiquitin-C
- Epidermal growth factor receptor substrate 15
- Vacuolar protein-sorting-associated protein 36
- Vacuolar protein-sorting-associated protein 25
- Vacuolar protein sorting-associated protein 28 homolog
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVEGSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPSQDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
Protein: AP-2 complex subunit alpha (Alpha-adaptin) (P91926)
Organism: Drosophila melanogaster (Fruit fly)
Function: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP-2alpha is a subunit of the plasma membrane adapter.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9118220, ECO:0000269|PubMed:9285813}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Membrane, coated pit {ECO:0000269|PubMed:9118220}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000269|PubMed:9118220}.
Interaction partners:
- AP complex subunit sigma
- Adaptor protein complex 2, mu subunit, isoform A
- Protein numb
- AP complex subunit beta
- Epidermal growth factor receptor pathway substrate clone 15, isoform A
- Clathrin heavy chain
- Carmine, isoform A
- Adaptor protein complex 1, mu subunit
- Clathrin light chain
- AP complex subunit sigma
Sequence:
MAPVRGDGMRGLAVFISDIRNCKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTPPSNNIGSGSNSNSTLIDVLGDMYGSNSNNNSSAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRYNGTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKVFKAAQPLDLPGARNKLMGFGMQLLDQVDPNPDNMVCAGIIHTQSQQVGCLMRLEPNKQAQMFRLTVRASKETVTREICDLLTDQF
Protein: NADPH-dependent FMN reductase ArsH (EC 1.-.-.-) (Arsenical resistance operon protein ArsH) (Q7UC03)
Organism: Shigella flexneri
Function: Has NADPH-dependent FMN reductase activity and very low azoreductase activity. No activity with NADH.
Interaction partners:
Sequence:
MRLRHLSDPDSLPALDKSFAIERPALGLAPDAPPVRILLLYGSLRARSFSRLAVEEAARLLQFFGAETRIFDPSDLPLPDQVQSDDHPAVKELRALSEWSEGQVWCSPERHGQITSVMKAQIDHLPLEMAGIRPTQGRTLAVMQVSGGSQSFNAVNTLRLLGRWMRMFTIPNQSSIAKAFQEFDAAGRMKPSPYYDRIADVMEELVRFTALVRPHREALTDRYSERKAAGHVIDEATDLSSIAIAPQPLPESETS
Protein: ARM REPEAT PROTEIN INTERACTING WITH ABF2 (ARIA) (B9DHT4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. Negative regulator of seed germination and young seedling growth.
Subcellular location: Nucleus {ECO:0000269|PubMed:15516505}.
Interaction partners:
- Cell division related protein-like
- Signal peptide peptidase-like 2
- Glutathione S-transferase 3, mitochondrial
- RING-H2 finger protein ATL43
Sequence:
MDQQPERREGRSFPERKGQKRKLEEGAAAVEDREISAVSTDGGQALLSEVAAQVSVLNSAFSWQESDRAAAKRATQVLAELAKNEDLVNVIVDGGAVPALMTHLQAPPYNDGDLAEKPYEHEVEKGSAFALGLLAIKPEYQKLIVDKGALPHLVNLLKRNKDGSSSRAVNSVIRRAADAITNLAHENSSIKTRVRVEGGIPPLVELLEFSDSKVQRAAAGALRTLAFKNDDNKNQIVECNALPTLILMLGSEDAAIHYEAVGVIGNLVHSSPHIKKEVLTAGALQPVIGLLSSCCPESQREAALLLGQFASTDSDCKVHIVQRGAVRPLIEMLQSPDVQLKEMSAFALGRLAQDAHNQAGIAHSGGLGPLLKLLDSRNGSLQHNAAFALYGLADNEDNVSDFIRVGGIQKLQDGEFIVQATKDCVSKTLKRLEEKIHGRVLRHLLYLMRISEKSIQRRVALALAHLCSPEDQRTIFIDDNGLELLLGLLGSLNTKQQLDGAAALYKLANKSMALSPVDAAPPSPTQRVYLGEQYVNNATLSDVTFLVEGRTFYAHRICLLASSDAFRAMFDGGYREKDARDIEIPNIKWEVFELMMRFIYTGSVDITNEISKDLLRAADQYLLEGLKRLCEYTIAQDITLESIGDMYELSEAFHAMSLRQACIMFILEHFDKLSSMPWQNELVQRTIPEIREYFCRALTKSTTNLQSLRL
Protein: Dual specificity phosphatase 6 (F8VZA4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGL