wanglab/gogpt-training-data huggingface dataset:
Protein: Protein Sxy (Competence activator Sxy) (P75869)
Organism: Escherichia coli (strain K12)
Function: Induces low levels of natural DNA uptake by inducing transcription of the competence genes (the CRP-S regulon) required for DNA transformation. Induction of the CRP-S regulon also requires Sxy-activated promoter (CRP-S), cAMP receptor protein (CRP) and cAMP. Induces CRP-S site-containing genes which are involved in genome maintenance and transcription or encoding transposases and toxin-antitoxin pairs.
Interaction partners:
- DNA-binding transcriptional dual regulator CRP
- NAD-dependent protein deacylase
- Prepilin peptidase-dependent protein D
- Outer membrane protein assembly factor BamC
- HTH-type transcriptional repressor CytR
- UPF0149 protein YgfB
Sequence:
MKSLSYKRIYKSQEYLATLGTIEYRSLFGSYSLTVDDTVFAMVSDGELYLRACEQSAQYCVKHPPVWLTYKKCGRSVTLNYYRVDESLWRNQLKLVRLSKYSLDAALKEKSTRNTRERLKDLPNMSFHLEAILGEVGIKDVRALRILGAKMCWLRLRQQNSLVTEKILFMLEGAIIGIHEAALPVARRQELAEWADSLTPKQEFPAELE
Protein: ATP binding cassette subfamily D member 3 (A0A3B3ITW3)
Organism: Homo sapiens (Human)
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004585}.
Interaction partners:
Sequence:
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIISRNKALFKKPFFKFIAATPMISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS
Protein: PITH domain-containing protein At3g04780 (Q9SQZ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 2Fe-2S ferredoxin-like superfamily protein
- K
- 26S proteasome non-ATPase regulatory subunit 14 homolog
- At1g80210/F18B13_28
- JAB1/Mov34/MPN/PAD-1 ubiquitin protease
- Mov34/MPN/PAD-1 family protein
- F-actin-capping protein subunit alpha
Sequence:
MSAESASQIPKGQVDLLDFIDWSGVECLNQSSSHSLPNALKQGYREDEGLNLESDADEQLLIYIPFNQVIKLHSFAIKGPEEEGPKTVKFFSNKEHMCFSNVNDFPPSDTAELTEENLKGKPVVLKYVKFQNVRSLTIFIEANQSGSEVTKVQKIALYGSTVETTDMKGLKKIEDH
Protein: Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein) (Pallidin) (Syntaxin 13-interacting protein) (Q9R0C0)
Organism: Mus musculus (Mouse)
Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UL45}. Membrane {ECO:0000250|UniProtKB:Q9UL45}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UL45}. Note=It can exist as a soluble protein as well as a peripheral membrane protein. {ECO:0000250|UniProtKB:Q9UL45}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- SNARE-associated protein Snapin
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Dysbindin
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- Syntaxin-12
- BLOC-2 complex member HPS6
- BLOC-2 complex member HPS5
Sequence:
MSVPEPPPPDGVLTGPSDSLEAGEPTPGLSDTSPDEGLIEDFPVDDRAVEHLVGGLLSHYLPDLQRSKRALQELTQNQVVLLDTLEQEISKFKECHSMLDINALFTEAKHYHAKLVTIRKEMLLLHEKTSKLKKRALKLQQKRQREELEREQQREKEFEREKQLTAKPAKRT
Protein: Solute carrier family 37 (glucose-6-phosphate transporter), member 4 (A0A1L1SUI3)
Organism: Mus musculus (Mouse)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MAAQGYGYYRTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPKDAFWTPALHPLAELTGFTEHEIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNIRTKMGRVSKKGE
Protein: Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5) (Q68EI3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09M02}. Nucleus {ECO:0000250|UniProtKB:Q09M02}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8NDL9}. Midbody {ECO:0000250|UniProtKB:Q8NDL9}.
Interaction partners:
- Tubulin tyrosine ligase-like family, member 1.
- ATP/GTP-binding protein-like 4.
- Tubulin polyglutamylase ttll6
Sequence:
MEIRVGSAVFSSRFDSGNLARVERVEASEAAGESSRSASVPQPDYEFNVWTRPDCASTEFENGNRSWFYFSVRGLLPGKLLKINMMNMNKQSKLYTQGMAPFVRTLPVKTRWERVRDRPTFEMSDSQFILSFVHRLLDVRGVTTYFSFCYPFSYAECQDMMLQLDHKFLSSTSTHTACSPPESIYYHRELLCHSLDGHRVDLITVSSCHGLLEEREPRLDKLFPDLSTARSHRFTGKRVFFVSSRVHPGETPSSFVFNGFLNFILSQEDPRAQTLRRMFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYVNPSPDLHPSIYGAKSLLLYHHIHNRLGHASGSALKTSNQSNTSPPVATPTERERCMNLRNEAERGEGPTFDLSEIPMQLEESWEKSGVQREAEHSDENESAQSRGETNSAPSEQVPPQESGVAYYIDLHGHASKRGCFMYGNNLTEESQQVENMLYAKLISLNCAHFDFLGCNFSEKNMYARDKRDGQSKEGSGRVAIHKAIGLVHSYTLECNYNTGRSVNTIPPACHDNGRATPPPPPAFPPKYTPEVYEQVGRAVAVAALDMAECNPWPRLVLSEHSSLLNLRASILKHVRNSTGLTSNNRRNTHCKTSSSPPKPVSLSTSASENSLNRTRSTTNVQGSRQTPQLKSSPSFTFGTTAHRPSHRSLGPVRECKAQEKRRPPPPPLPHHHHQQHQRLSVRLSAPVRAPLSPSSSSSSSSSSPSSSSSAPGPGSISLAGNSCPEFRPANQIKELRGGRGKGGRSGPAYCHSSQQRTALTTKEPLQDSLDILTSIEYSRCELQPRPSRIPVRRELQSSVIPLSSTETPTMRVWKLIKPGLKKHLAGVSGKDRLSTKALLKNSSRQTDQHIHRSLPT
Protein: NKD inhibitor of WNT-signaling pathway 3 (E7F1Y9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSLFTSVFRQLSACFTPSWGRRLSPQIADIGAEAGESKAMSTQKHRKVKSHHGHRPGKEGEGLKDQAEEEKQALSAENIQSTEREGGNGEPGGKKRKRRKLKNKKTLPLPVEVKPLPAPACFSSSSPPVGDQPEHPDVLALPAAGLKPLLKDKESLPRLVEVKPLPASACFSSLTPVGDQPEHPEVLVLPASHLKALSPLSNPASRPQSPVEETDEVLPSSVIQVAPCVSPEPVLLPLQSSSEVASLCSIPSFSEPSLLQSPPETLPIPPIFAFDKVVSLVKPQASECSPSSGLMLFDFEDEELEFMEYTEEDIEAFYESEMKPRRMAAWLEQEEVTEVQIDGGKGASQVIQNPLNEVSRDEAFEELLIQAFCTGPPVYTEIKSRKKPKRNGPLVLFSLMEEKVKKKQEKKLRKEEERNERNLLRERYRNDPKLKHLCINKHNPNFCWS
Protein: Sperm-associated microtubule inner protein 10 (Testis-expressed protein 43) (Q9D9I1)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37989994}. Note=Localizes at the ribbon and inner junction (IJ) between A- and B-tubules of the DMTs. {ECO:0000269|PubMed:37295417}.
Interaction partners:
- Testis-expressed protein 35
- Leucine-rich repeat-containing protein 43
- Spermatogenesis-associated protein 45
Sequence:
MASEKDDGPALPKLDDDNQTAENTCKPAEEQPQQLRWDDIHLPRFSLKQGMIPTRYVMPWKENMKFRNVNLQQAEACGIYAGPLEDSLFWGYSERLCHGEDRKAVLKKGLPEIKITDMPLHSPLSRYQSTVISHGFRRRLI
Protein: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein (Q9JJC9)
Organism: Mus musculus (Mouse)
Function: Could be involved in the unfolded protein response (UPR) pathway.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDQSGMEIPVTLIIKAPNQKYSDQTISCFLNWTVGKLKTHLSNVYPSKPLTKDQRLVYSGRLLPDHLQLKDILRKQDEYHMVHLVCASRSPPSSPKSSTDRGSHEALASSTSSNSDHSDSTTPSPSQESLSLVTGSSEGLRQRTLSQAQTDPAQSHQFPYVIQGNVDHQFPGQGVPPAFPVYPALSPLQMLWWQQMYAHQYYMQYQAAVSAQATSSAGSAQRAASSPLNLAHVPGEEPPPAPNLVAQENGPMNENVQMNAQGGPVLNEEDLNRDWLDWVYTFSRAAVLLSIVYFYSSFSRFIMVMGAMLLVYLHQAGWFPFRQEGGQQQAPNNVDANNDGHNANNLELEEMERLMDDGLEDESGEDAGEDASAAQRPGLMASAWSFITTFFTSLIPEGPPQVAN
Protein: Large ribosomal subunit protein eL27A (60S ribosomal protein L27-A) (P0C2H6)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL8B
- Large ribosomal subunit protein eL14B
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL6B
- Large ribosomal subunit protein eL36B
- Small ribosomal subunit protein eS24A
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein uS7
Sequence:
MAKFLKAGKVAVVVRGRYAGKKVVIVKPHDEGSKSHPFGHALVAGIERYPLKVTKKHGAKKVAKRTKIKPFIKVVNYNHLLPTRYTLDVEAFKSVVSTETFEQPSQREEAKKVVKKAFEERHQAGKNQWFFSKLRF
Protein: NH(3)-dependent NAD(+) synthetase (EC 6.3.1.5) (Nicotinamide adenine dinucleotide synthetase) (NADS) (Nitrogen regulatory protein) (P18843)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
Interaction partners:
- Nicotinate-nucleotide adenylyltransferase
- Trifunctional NAD biosynthesis/regulator protein NadR
- Nicotinate phosphoribosyltransferase
- NAD kinase
- Nicotinamide-nucleotide amidohydrolase PncC
- NAD-dependent protein deacylase
- NAD
- NAD
- NAD-capped RNA hydrolase NudC
- Nicotinamidase
Sequence:
MTLQQQIIKALGAKPQINAEEEIRRSVDFLKSYLQTYPFIKSLVLGISGGQDSTLAGKLCQMAINELRLETGNESLQFIAVRLPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAVLASEQALREAGIELSDFVRGNEKARERMKAQYSIAGMTSGVVVGTDHAAEAITGFFTKYGDGGTDINPLYRLNKRQGKQLLAALACPEHLYKKAPTADLEDDRPSLPDEVALGVTYDNIDDYLEGKNVPQQVARTIENWYLKTEHKRRPPITVFDDFWKK
Protein: p53 and DNA damage-regulated protein 1 (Q9NUG6)
Organism: Homo sapiens (Human)
Function: May play a role in chaperone-mediated protein folding.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Prefoldin subunit 6
- Prefoldin subunit 2
- Protein UXT
- Dynein axonemal assembly factor 10
- RNA polymerase II-associated protein 3
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- PIH1 domain-containing protein 1
- Unconventional prefoldin RPB5 interactor 1
- RuvB-like 1
- RuvB-like 2
Sequence:
MLSPEAERVLRYLVEVEELAEEVLADKRQIVDLDTKRNQNREGLRALQKDLSLSEDVMVCFGNMFIKMPHPETKEMIEKDQDHLDKEIEKLRKQLKVKVNRLFEAQGKPELKGFNLNPLNQDELKALKVILKG
Protein: NADH-dependent fumarate reductase, putative (Q57W39)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Succinate dehydrogenase, putative
- Electron transfer protein, putative
- Reiske iron-sulfur protein, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Succinate dehydrogenase assembly factor 2, mitochondrial
- Uncharacterized protein
- Uncharacterized protein
- Citrate synthase
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
Sequence:
MCHTRVWASMRLHGCLLSPLTSVSMCHPFWLQFFVCSFHLFLDTVARVSFTGLKSLTHRNRLVGVAMFSGPAEVYYTKSIQNNHRQLRRNVGGAQPGRGIYYSLLAVLLVVTFIKTASAMLERVRVGIDMIRSREMAMVESENPRVIVVGGGLAGLSAAIEAAGCGAQVVLMEKEAKLGGNSAKATSGINGWGTRAQAKASIVDGGKYFERDTYKSGIGGNTDPALVKTLSMKSADAIGWLTSLGVPLTVLSQLGGHSRKRTHRAPDKKDGTPLPIGFTIMKTLEDHVRGNLSGRITIMENCSVTSLLSETKERPDGTKQIRVTGVEFTQAGSGKTTILADAVILATGGFSNDKTADSLLREHAPHLVNFPTTNGPWATGDGVKLAQRLGAQLVDMDKVQLHPTGLINPKDPANPTKFLGPEALRGSGGVLLNKQGKRFVNELDLRSVVSKAIMEQGAEYPGSGGSMFAYCVLNAAAQKLFGVSSHEFYWKKMGLFVKADTMRDLAALIGCPVESVQQTLEEYERLSTSQRSCPITRKSVYPCVLGTKGPYYVAFVTPSIHYTMGGCLISPSAEIQMKNTSSRAPLSHSNPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGASAANAKYHNETHLWNNRWAKMVVESVLDDTNGYQWLYFRLPSTLQRSGVGPLQAVVLREMEGEGRLDVRIPFTVPGDVGVVGIMVYSNDENSSMGWLTALLPGGMVEMKAGVQVDANYERILALPRKVIIATRDGVAPMVQMIRAALHEAKDEPALQIIYIAERVATIPQREKLEQLQRDHPNKFKFTFVVHDPPPLWTGGVNIMEEISKSVFPDASLGVFLFASATESASLQVQLLELGHNKSNIVTL
Protein: IGF-like family receptor 1 (Transmembrane protein 149) (U2 small nuclear RNA auxiliary factor 1-like 4) (Q9H665)
Organism: Homo sapiens (Human)
Function: Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21454693}; Single-pass type I membrane protein {ECO:0000269|PubMed:21454693}.
Interaction partners:
- Insulin growth factor-like family member 1
- Insulin growth factor-like family member 3
Sequence:
MGPGRCLLTALLLLALAPPPEASQYCGRLEYWNPDNKCCSSCLQRFGPPPCPDYEFRENCGLNDHGDFVTPPFRKCSSGQCNPDGAELCSPCGGGAVTPTPAAGGGRTPWRCRERPVPAKGHCPLTPGNPGAPSSQERSSPASSIAWRTPEPVPQQAWPNFLPLVVLVLLLTLAVIAILLFILLWHLCWPKEKADPYPYPGLVCGVPNTHTPSSSHLSSPGALETGDTWKEASLLPLLSRELSSLASQPLSRLLDELEVLEELIVLLDPEPGPGGGMAHGTTRHLAARYGLPAAWSTFAYSLRPSRSPLRALIEMVVAREPSASLGQLGTHLAQLGRADALRVLSKLGSSGVCWA
Protein: Nuclear receptor interacting protein 1 (G3V672)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Estrogen receptor
- Estrogen-related receptor gamma
- Hepatocyte nuclear factor 3-alpha
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- GATA-binding protein 3.
- Transducin-like enhancer protein 3
- RAR-related orphan receptor C
- Nuclear receptor corepressor 1
- Retinoic acid receptor, alpha
- Estrogen receptor beta
Sequence:
MTHGEELGSDVHPDSIVLTYLEGLLMHQAAGGSGTAVDKKSAGHSEEDQNFNLSGSAFPTCQSNGPTLSTQTYQGSGMLHLKKARLLQSSEDWNAAQRKRLSDSIVNLNVKKEALLVGMVDSVPKGKQDSTVLASLLQSFSSRLQTVALSQQIRQSLKEQGYALSHESLKVEKDLRCYGVASSHLKTLLKKSKTKDQKSGTTLPDVTPNLIRDSFVESSPHHVGQSGTKVMSEPLSCAARLQAVASMVEKRASPAASPKPSVACSQLALLLSSEAHLQQYSREHALKTQSAHQAASERLAAMARLQENGQKDMSSFQLSKGVSGHLDGQARTLPQSSKLAASKNNAAVFQNPMCGVPSSPKNTSYKNSLERNNIKQAANNSLLLHLLKSQTIPTPMNGHSQHERGSSFESSTPTTIDEYSDNNPSFTDDSSGDESSYSNCVPIDLSCKHRTEKPETERPVSLENLTQSLLNTWDPKVPGVDIKEDQDTSTNSKLNSHQKVTLLQLLLGHKTEESVERNASPQEVHSDVTKFSPQNYTRTSVIESPSTNRTTPVSTPPLHTSSQGESPINLSQHSLVIKWNSPPYACSTPASKLTNTVTGHLMDLTKGKESQAEKPAPSEGAQNSATFSASKLLQNLAQCGMQSSVPGEEQRPSKQLLSGHTDKPLGLIDRLNSPLLSNKANAAEENKAFSSQPAGPEPGLPGCEIENLLERRTVLQLLLGNSNKGKSEKKERAPALDEARQEHSERPGNEQILMVKIKSEPCDDFQTHNTNVHLNHDAKSTPFLGGTPTIQRSSAALPVSEDLKSEPASPQDFSFSKNGLLSRLLRQNQESYPADDQDKSHRNSELTPLESKNFCMVPKKRKLYTEPLENPFKKMKNSAVDNANNHGGPEVLYGSLLNQEELKFSRNDLDYKYSAGHSSASDGEHRSWARESKSFNVLKQLLLSENCVRDLSPHRSNSVTDNKKKGHKNNVPNSKPEFSISSLNGLMYGSPQPGSCVDHRTFSYPGMVKTPLSSPFPEHLGCVGSRPEPGLLNGCSVPVPGEKGPIKWVITDVEKNEYEKDSPRLTKTNPILYYMLQKGGNSVTTQETQDKDIWGEPSSAESLSQVTVKEEMLPAAETKAAFFNLRSPYNSHMGNNASRPHSTNGEAYGPLGNVLTIKKECE
Protein: cGMP-dependent protein kinase (EC 2.7.11.12) (A0A8I6B3H1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDYSDTDSDSTLGYSDDEDSSDDVERVSEEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF
Protein: dihydrofolate reductase (EC 1.5.1.3) (C9JJ68)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIW
Protein: Nuclear transcription factor Y subunit C-1 (AtNF-YC-1) (Transcriptional activator HAP5A) (Q9SMP0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Nuclear transcription factor Y subunit B-3
- Nuclear transcription factor Y subunit B-1
- Nuclear transcription factor Y subunit B-2
- Nuclear transcription factor Y subunit A-1
- Nuclear transcription factor Y subunit B-8
- Nuclear transcription factor Y subunit B-7
- Nuclear transcription factor Y subunit B-6
- Nuclear transcription factor Y subunit A-2
- Nuclear transcription factor Y subunit B-4
- Nuclear transcription factor Y subunit B-5
Sequence:
MDTNNQQPPPSAAGIPPPPPGTTISAAGGGASYHHLLQQQQQQLQLFWTYQRQEIEQVNDFKNHQLPLARIKKIMKADEDVRMISAEAPILFAKACELFILELTIRSWLHAEENKRRTLQKNDIAAAITRTDIFDFLVDIVPRDEIKDEAAVLGGGMVVAPTASGVPYYYPPMGQPAGPGGMMIGRPAMDPNGVYVQPPSQAWQSVWQTSTGTGDDVSYGSGGSSGQGNLDGQG
Protein: Nucleobindin-2 (DNA-binding protein NEFA) (Prepronesfatin) [Cleaved into: Nesfatin-1] (Q9JI85)
Organism: Rattus norvegicus (Rat)
Function: Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.
Subcellular location: Golgi apparatus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus envelope {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: [Nesfatin-1]: Secreted.
Interaction partners:
- Appetite-regulating hormone
Sequence:
MRWRTIQARYCFLLVPCVLTALEAVPIDVDKTKVHNVEPVESARIEPPDTGLYYDEYLKQVIEVLETDPHFREKLQKADIEEIRSGRLSQELDLVSHKVRTRLDELKRQEVGRLRMLIKAKLDALQDTGMNHHLLLKQFEHLNHQNPDTFESKDLDMLIKAATADLEQYDRTRHEEFKKYEMMKEHERREYLKTLSEEKRKEEEAKFAEMKRKHEDHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNNDGFLDEQELEALFTKELDKVYNPQNAEDDMIEMEEERLRMREHVMNEIDNNKDRLVTLEEFLRATEKKEFLEPDSWETLDQQQLFTEEELKEYESIIAIQESELKKKADELQKQKEELQRQHDHLEAQKQEYQQAVQQLEQKKFQQGIAPSGPAGELKFEPHT
Protein: Glutathione S-transferase Z1 (AtGSTZ1) (EC 2.5.1.18) (GST class-zeta member 1) (Glutathione S-transferase 18) (Maleylacetone isomerase) (MAI) (EC 5.2.1.-) (Q9ZVQ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts a maleylacetone isomerase. Also catalyzes the glutathione-dependent dehalogenation of dichloroacetic acid to glyoxylic acid. In vitro, possesses glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}.
Interaction partners:
- Homogentisate 1,2-dioxygenase
- Fumarylacetoacetase
- Glutathione S-transferase Z2
- Probable elongation factor 1-gamma 2
- Glutathione S-transferase U19
- Glutathione S-transferase L1
- Glutathione S-transferase family protein
- Glutathione S-transferase L2, chloroplastic
- Probable elongation factor 1-gamma 1
- AT5g45020/K21C13_21
Sequence:
MANSGEEKLKLYSYWRSSCAHRVRIALALKGLDYEYIPVNLLKGDQFDSDFKKINPMGTVPALVDGDVVINDSFAIIMYLDEKYPEPPLLPRDLHKRAVNYQAMSIVLSGIQPHQNLAVIRYIEEKINVEEKTAWVNNAITKGFTALEKLLVNCAGKHATGDEIYLADLFLAPQIHGAINRFQINMEPYPTLAKCYESYNELPAFQNALPEKQPDAPSSTI
Protein: Lipopolysaccharide heptosyltransferase 3 (EC 2.4.99.25) (ADP-heptose:lipopolysaccharide heptosyltransferase III) (ADP-heptose:LPS heptosyltransferase III) (Heptosyltransferase III) (P25742)
Organism: Escherichia coli (strain K12)
Function: Catalyzes heptose transfer to the lipopolysaccharide core. It transfers a heptose, called heptose(III), to the heptose(II) of the inner core (By similarity).
Interaction partners:
- Lipopolysaccharide glucosyltransferase WaaG
- Lipopolysaccharide core heptose
- Lipopolysaccharide 1,6-galactosyltransferase
- Lipopolysaccharide heptosyltransferase 1
- Lipopolysaccharide glucosyltransferase WaaO
- Bifunctional protein HldE
- Lipopolysaccharide core biosynthesis protein WaaS
- 3-deoxy-D-manno-octulosonic acid transferase
- Lipopolysaccharide core heptose
- ADP-L-glycero-D-manno-heptose-6-epimerase
Sequence:
MRYHGDMLLTTPVISTLKQNYPDAKIDMLLYQDTIPILSENPEINALYGISNKGAGTFDKIKNVLSLIKTLRANNYDLVINLTDQWMVALLVRCLPARMKISQLYGHRQHGIWKKSFTHLAPIHGTHIVERNLSVLEPLGITDFYTDTTMSYAEDCWKKMRRELDALGVKDHYVVIQPTARQIFKCWDNDKFSKVIDALQQRGYQVVLTCGPSADDLACVDEIARGCETKPITGLAGKTRFPELGALIDHAVLFIGVDSAPGHIAAAVKTPVISLFGATDHVFWRPWTENIIQFWAGNYQKMPTRHELDRNKKYLSVIPAEDVIAATEKLLPEDAPSADRNAQL
Protein: Neutral ceramidase B (N-CDase B) (NCDase B) (EC 3.5.1.23) (Acylsphingosine deacylase 2B) (N-acylsphingosine amidohydrolase 2B) (Q55G11)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Sphingosine kinase B
- Sphingosine kinase A
- Glucosylceramidase
- Putative alkaline ceramidase dcd3B
- Putative alkaline ceramidase dcd3A
- 3-ketodihydrosphingosine reductase
- sphingolipid 4-desaturase
- Sphingomyelin phosphodiesterase A
- Probable sphingosine-1-phosphate phosphatase
- Sphingomyelin phosphodiesterase B
Sequence:
MINSFKKLIILISLVIILLSSNNIFIDSFKIPVNQKNVKSSGDSSYQIGAGIYDITGASAEVNLMGYANPLQVGAGIHFRQRARAFVFVDSNGNRAVYVSTDSCMIFQEVKIHVVELLQDIFGPNVYTEANVLLSGTHTHSGPAGFSQYALYGITSLGFYKKNFDTICNGIVQAIVKAHKSVQPANMFTETGELWNTNINRSPFAYDNNPEEEKAMYDSNVDKNMTVLRIEDMNGNPFAAISFFAVHCTSMNNTNHLISGDNKGYASYLWEKQVNGPGTAGKGPFVAAFGQSNEGDVSPNTRGPTCRDGSPCDYKTSTCNGRNEECWSLGPGKDGDMFESTQIIGGNQFNKALELFNNASIQVSGPVQYRHSWVQFTNVSVEPPYNSGVDNATTCRGAMGYSFAAGTTDGPGAFNFVQSDNNTSGNPFWNFIGDFIAKPTPDQIRCQSPKPILLDVGMVEPIPWVPDVMPIQIVTIGQIVLVAVPGEFTTMSGRRLRNSVREIIGESIENPIVLIAGLSNTYSGYIATFEEYQVQRYEGASTVFGPHTLGSYMQEFGKLAQSIVDGTTVPAGPTPRNLTGHTLFFLPPVIVDAAPDFDDFGEVSIDVNLNYSVNETVSCVFYGGNPRNDFMIESSFLSVDLLTGTDQWTTVLDDGDWDTKFKWKMHDLGFSLITIEWVIAPDTTPGTYRITHSGFAKKNPFSSNLTPYQGISRNFVVQ
Protein: Antitermination NusB domain-containing protein (At4g26370) (Q93XY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEGTFSPLCLRSSSNLCYFSSNVSPDSHRSIGFTLVDSLRPTNLVSLRTGNKRSSSSSLRLFLSPTRSALRTPTISAEEVKDVPMPKIDKSGRLSSPRAARELALVILYAACLEGSDPIRLFEKRINARREPGYEFDKSSLLEYNHMSFGGPPVKTETKEEEDELVRHDEKESKIEAEVLSAPPKLVYSKLVLRFAKKLLAAVVDKWDSHVVIIEKISPPDWKSAPAGRILEFSILHLAMSEVAVLETRHPIVINEAVDLAKRFCDGSAPRIINGCLRTFVKDRATTSTPQALELKQEVSV