wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) (O15381)
Organism: Homo sapiens (Human)
Function: Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity.
Subcellular location: [Isoform 2]: Nucleus, nucleoplasm {ECO:0000269|PubMed:15469983}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:9286697}. Nucleus, nucleoplasm {ECO:0000269|PubMed:15469983}. Note=Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus. {ECO:0000269|PubMed:16782053}.
Interaction partners:
- Exosome RNA helicase MTR4
- Telomerase reverse transcriptase
- Guanine nucleotide-binding protein-like 3-like protein
- H/ACA ribonucleoprotein complex subunit DKC1
- H/ACA ribonucleoprotein complex subunit 2
- H/ACA ribonucleoprotein complex subunit 1
- H/ACA ribonucleoprotein complex subunit 3
- Telomerase protein component 1
- Nucleolar MIF4G domain-containing protein 1
- Telomerase Cajal body protein 1
Sequence:
MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR
Protein: Sperm-egg fusion protein LLCFC1 (LLLL and CFNLAS motif-containing protein 1) (MSSP-binding protein CTM-1) (Sperm-oocyte fusion required protein 1) (Q9D9P8)
Organism: Mus musculus (Mouse)
Function: Sperm protein required for fusion of sperm with the egg membrane during fertilization.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Fertilization-influencing membrane protein
Sequence:
MTSLGSQLHRATFLTALLLLLLLQVKGVKTLIVSASLDGDKSQKDKVSSEDQGEEEYEEHFEASSEGEQWQEIDMVQQEDTISQAITLQDHLLDLAFCFNLASIMFFL
Protein: Myosin, light chain 13 (A0A060VX90)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Myosin tail domain-containing protein
- Myosin motor domain-containing protein
- Myosin tail domain-containing protein
- Myosin motor domain-containing protein
- Myosin motor domain-containing protein
- Myosin motor domain-containing protein
- Myosin motor domain-containing protein
Sequence:
MAPKKKEEPKEAPKPKAPEPEPVKIPEFNPTEVVLEFTPEQIEDFKDAFQLFDRTPLNEMKITYGQCGDVIRALGQNPTNAEITYVLGKPKAEEMATKMLDFDSFLPIHQHICKAKDRGTYEDFVEGLRVFDKLGDGTVMGAELRHVLASLGEKMKEDEVEQLMTNQEDANGCVNYEDFVKHVMAS
Protein: mitogen-activated protein kinase (EC 2.7.11.24) (B4E0K5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Protein: Endo-1,4-beta-xylanase A (Xylanase A) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase A) (22 kDa xylanase) (Xylanase X22) (P55332)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular location: Secreted {ECO:0000269|PubMed:25043916, ECO:0000269|PubMed:8787417}.
Interaction partners:
- Endo-1,4-beta-xylanase C
- Xylanolytic transcriptional activator xlnR
- Exo-1,4-beta-xylosidase xlnD
- Alpha-L-arabinofuranosidase B
- DNA-binding protein creA
- Alpha-glucuronidase A
- endo-1,4-beta-xylanase
Sequence:
MVSFKSLLVLCCAALGAFATPVGSEDLAAREASLLERSTPSSTGWSNGYYYSFWTDGGGDVTYTNGAGGSYTVQWSNVGNFVGGKGWNPGSTRTINYGGSFNPSGNGYLAVYGWTQNPLIEYYIVESYGTYNPGSGGQHRGTVYSDGATYDIYTATRYNAPSIEGTATFEQFWSVRQSKRTGGTVTTANHFNAWAALGMRLGTHNYQIVATEGYQSSGSASITVY
Protein: ER export of PMA1 protein 1 (Q07541)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Specific cargo receptor protein for the plasma membrane ATPase PMA1 that acts with PSG1 to promote the transport and maturation of PMA1. EXP1 and PSG1 probably act sequentially to promote PMA1 sorting between the ER and the Golgi, with EXP1 promoting PMA1 export from the ER to the Golgi while PSG1 has a role in PMA1 maturation or quality control in the Golgi.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28727280}; Single-pass type I membrane protein {ECO:0000305|PubMed:28727280}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:28727280}; Single-pass type I membrane protein {ECO:0000305|PubMed:28727280}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:28727280}; Single-pass type I membrane protein {ECO:0000305|PubMed:28727280}. Golgi apparatus membrane {ECO:0000269|PubMed:28727280}; Single-pass type I membrane protein {ECO:0000305|PubMed:28727280}. Note=Cycles between the ER and the Golgi apparatus. {ECO:0000269|PubMed:28727280}.
Interaction partners:
- Uncharacterized protein YBL086C
Sequence:
MNLYGYFLLLIIVIAFIALLPLFSGIGTFKLTKPKSSATAQSATGKLGKREYLKKKLDHTNVLKFDLKDTEESLGHDSASASSASRKFEIDSKTGLKRRVIGQYNKDPNDFDFDIDDLINEDELDERREEEKKLKKYNGKKNEAYEGFV
Protein: GTPase-activating protein (A0A1D8PNF8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha
- G protein subunit beta
- Guanine nucleotide-binding protein subunit alpha
- Alpha-factor pheromone receptor
- Chitin synthase export chaperone
- Protein kinase domain-containing protein
- Serine/threonine/tyrosine protein kinase
- Glycogen synthase kinase 1
- Fus1p
- Cyclin-dependent protein serine/threonine kinase inhibiting protein
Sequence:
MDSIITINMPRDNMELDYDCQKHTKGSILLASITPQNTKLLTELGCSPSKTSILHEATHHKFSRTSSGRIFEKDIKDIFSLLIISLRLERDGLTNYLFNSPPIIKLHKPLRKSYPYSFSLESAIEKMKDLQLDVESVNTVTCISYSFKSEVSLALIEQFYKARLLHSPADRTRSGAKSNVALQPTPKGIAIVQEFCERIGMEREEFPEVLLAHDFNTMELFNFDRDTRSDRILYSEYLLYLLFNLMMGPEPNVWTPSNTQDALPSLNFSDSESFDKLYKVFSNSQDAKNAKQNNDDSSDVEGFSFTSYRHFSKTHQSSETHSVTDSKEMATSPFHHRYFTNPESDAHSQYYVSSVGVRLLKDKIVLVGPNKSVTVDYCISGKAIYQWILDCTDIINPNHAHEIARLLVKHNLIKPVSFSSSLSFSRDAFYQLSTLGLALSSWDFFDRNLQDSSSLQPGTKILRLASNVTLQNILNDPGMRLQFRKHLIKDHCVENLEAYIQLMQFEETYKAWEDLSDIIDNQNHSCIPVKSSDVNIHLKDLQVTCMSFAFQIFHTYLSIDSPKIVNIDFRLRSKITTLMIGDSGARDNGDNESIIYLQTPTEDFALGSSVSEEAGGSTPRCHDHDELSAPANNFRKIANSLLQIKLQIYHLMEVDSIPKFLETLGVTSNRIITTF
Protein: Sodium-dependent neutral amino acid transporter B(0)AT3 (Renal osmotic stress-induced Na-Cl organic solute cotransporter) (ROSIT) (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3) (Q62687)
Organism: Rattus norvegicus (Rat)
Function: Symporter that transports one amino acid molecule together with two sodium and one chloride ions in kidneys and plays a role in the neutral amino acids reabsorption. Preferentially transports neutral amino acids such as L-glycine and L-alanine but also other neutral amino acids. Required CLTRN for cell surface expression and for its amino acid transporter activity. The transport mechanism is pH-independent.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:O88576}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O88576}; Multi-pass membrane protein {ECO:0000255}. Note=In kidneys localizes to the apical membrane in distal segments of the proximal tubule. Cell membrane expression is CLTRN-dependent. {ECO:0000250|UniProtKB:O88576}.
Interaction partners:
- Collectrin
- Angiotensin-converting enzyme 2
- Proton-coupled amino acid transporter 2
- Transmembrane protein 174
Sequence:
MAQASGMDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFEGIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTILLWVLWFFLNSFQHPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTIQWKLFLCLVACWTTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLTYLFTPNMKILQNSRVWLDAATQIFFSLSLAFGGHIAFASYNQPRNNCEKDAVTIALVNSMTSLYASITIFSIMGFKASNDYGRCLDRNILSLINEFDFPELSISRDEYPSVLMYLNATQPERVARLPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITPLFDMGILPKGVPKETMTGVVCFICFLSAICFTLQSGSYWLEIFDSFAASLNLIIFAFMEVVGVIHVYGIKRFCDDIEWMTGRRPSLYWQVTWRVVSPMLLFGIFLSYIVLLAQSSPSYKAWNPQYEHFPSREEKLYPGWVQVTCVLLSFLPSLWVPGIALAQLLFQYRQRWKNTHLESALKPQESRGC
Protein: (-)-alpha-pinene synthase 1, chloroplastic (EC 4.2.3.119) ((-)-beta-pinene synthase 1) (EC 4.2.3.120) (Terpene synthase TPS-Pin) (PsTPS-Pin) (F2XFA8)
Organism: Picea sitchensis (Sitka spruce) (Pinus sitchensis)
Function: Terpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (1S,5S)-beta-pinene.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MALVSIAPLASKSCLHKSLSSSAHELKTICRTIPTLGMSRRGKSATPSMSMSLTTTVSDDGVQRRMGDFHSNLWNDDFIQSLSTSYGEPSYRERAERLIGEVKKMFNSMSSEDGELISPHNDLIQRVWMVDSVERLGIERHFKNEIKSALDYVYSYWSEKGIGCGRESVVADLNSTALGFRTLRLHGYAVSADVLNLFKDQNGQFACSPSQTEEEIRSVLNLYRASLIAFPGEKVMEEAEIFSAKYLEESLQKISVSSLSQEIRDVLEYGWHTYLPRMEARNHIDVFGQDTQNSKSCINTEKLLELAKLEFNIFHSLQKRELEYLVRWWKDSGSPQMTFCRHRHVEYYTLASCIAFEPQHSGFRLGFAKACHIITILDDMYDTFGTVDELELFTAAMKRWDPSAADCLPEYMKGVYLILYDTVNEMSREAEKAQGRDTLDYARRAWDDYLDSYMQEAKWIATGYLPTFAEYYENGKVSSGHRTSALQPILTMDIPFPPHILKEVDFPSKLNDLACAILRLRGDTRCYKADRARGEEASSISCYMKDNPGATEEDALDHINAMISDVIRGLNWELLNPNSSVPISSKKHVFDISRAFHYGYKYRDGYSVANIETKSLVKRTVIDPVTL
Protein: Eukaryotic translation initiation factor 6 (eIF-6) (Q551M2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}. Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-Rule:MF_03132}.
Interaction partners:
- Large ribosomal subunit protein uL3
- Probable ribosome biogenesis protein RLP24
- Large ribosomal subunit protein eL31
- 60S ribosomal export protein NMD3
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein eL20
- Ribosome assembly factor mrt4
- Large ribosomal subunit protein uL16
Sequence:
MATRLQYENSCDVGVFLKLTNKYCLVGQCGSKQFLHTVENRLADHIPVVETSIAGTRIVGRLSAGNKNGLLLPNTCTDQELQQIRNSLPDDVVVQRIEEKFSALGNCIATNDYVALVHPDIDRETEEIIADVLGVEVFRQTVSGNVLVGTYCALTNQGALVHPMTSIADQDELSSLLQVPLVAGTVNRGNECVAAGCVVNDWTAIVGADTTATEISVIESIFALQGSKPSNIINNIRNSIVDNV
Protein: Myosin, essential light chain (Myosin light chain alkali) (P53014)
Organism: Caenorhabditis elegans
Interaction partners:
- Myosin regulatory light chain 1
- Myosin regulatory light chain 2
- Troponin T
- Tropomyosin isoforms a/b/d/f
- Myosin-4
- Myosin-3
- Myosin regulatory light chain
- Myosin-1
- Paramyosin
- Troponin I 2
Sequence:
MAPPSQDVLKEIFNLYDEELDGKIDGTQVGDVARAAGLKPTQAMVTKAAGQEFKRKGEKRLTFEEWLPMYEQLAKEKEQGTYADFYEGLKVFDKEETGKILAAELRHILLALGERLSADEADELLKGVEDGEGMVKYEDFIKKVLAGPFPDQD
Protein: Basic helix-loop-helix protein 004 (AtbHLH004) (bHLH 004) (bHLH transcription factor bHLH004) (Q336V8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q10S44, ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm {ECO:0000250|UniProtKB:Q10S44}. Note=Localizes mainly in the nucleus. {ECO:0000250|UniProtKB:Q10S44}.
Interaction partners:
Sequence:
MELMDDDGSSSLLEELMAPLRRGTPTTTPEDLWLQAYPMMMSPMCGDGVMLGDLLVGGGNARNTLASPPPPSFPLPVPLTTTTPCPPLHEVSFEFDSIDCLGEVCNPYKRSGGAVRATAAAQVMVAAMDPRREAASSAVAVAAVEEEERCKARRGAGGGGDSGELAPMFVFGGGGGAAASVRPRSCRPPQPGAPSKNLMAERRRRKRLNDRLSMLRSVVPRISKMDRTSILGDTIGYVKELMDRIKNLQVEAATGDSSSSSTENLSMLKLNTLKPPPSSSSGEETPLIRNSTRFEVERRENGSTRIEMACAAIPELLPSTLAALEALGVEIEQCVISCFDDFAMQASCLQDDKKREMTRDTEEIKQTLFRSAGYGDGCLI
Protein: GM01970p (Q95TW1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNLPAKMDVEKDKLRQMHCEFNPLSRCDGSVMYSQGATGLIGAVLGPIEVKTQNLSIDGSYLECNYRPKAGLPQVTDRIREAAIRDVLELALLSEAHPRSKMSVQIQELEDRGSIDACAVNCACLAMLIGGLPLKYSFAAVHAIINEQGEYVLDPDQSETLHQRASFTFAFDSVEGNLLLIQTKGSFKIAQFNDIECLCRAASAEIFQFYRNQVAKYHGRSEATAKKEDVNET
Protein: Neuromedin U receptor homolog nmur-2 (Pyrokinin receptor homolog) (CAPA-PK receptor) (PK receptor homolog) (PK-R) (O17239)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Nematocin receptor 1
- Neuropeptide precursor capa-1
- G-protein coupled receptors family 1 profile domain-containing protein
Sequence:
MSQCTVEYNVSEITEYVLSTLGERCQSAGIVIPTVIIYGTIFLLGLFGNICTCIVIAANKSMHNPTNYYLFSLAVSDIIALILGLPMEFYQSLDYSYPYRFSEGICKARAFLIEFTSYASIMIICCFSFERWLAICHPLRSKIFSTLWRANVLIILAWTISFVCALPIAFIVQINKLPLPEDAKYQPWTNKVSTDGIFVLHTEFCAMNQSRPDQQKMIIIFAFTVFFVIPAIAIVIMYAHIAVQLESSEIDLKGDKMVKKRRNKSNRTVLKMLLSVVITFFICWLPFHIQRLLSVYTTWSETTTISPPVQFLSMIVFYISGFCYYSNSAANPILYNILSQKYRSAFCRTILGDHIANFVFKGHQRPGQSKRCSSSTEAEQRTLMTRGSVRVDKPHRKLEVHNY
Protein: Interleukin-2 (C1LZ14)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
RLLAGIDYLEENITCPDSVFYTPTDVEDSCIVAALACSIKELDTVKVECLDKAVHLESMQHHISMTATALQKTIDKENSTTDTSECICEDKR
Protein: Protein slt1 (O13791)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MATLFHLIDVHGNEYQNVQDHSLQMALEELNQQIEVIQRQEEQLALRKKAIEDARQEVLQQIQHRKFRQYLHEREQEARLQEYYLEQLQERRAFENVVRTIIRKRFEDEERERAHRREKAARKLLRRILVSDSPNMQLVVPNNFQQMFIHHPVVDTIYSPEESSESQAEVADQQTGPYSTSEYAGAQQSQPFRIFIQNDNAPEQQSGPDVAELNTLPNRSKTSSQASVSDEELSRTELAELNDYLLAAQRRSNKRGNARKHIDLTARESPSTSFAQMSKGALNPDPEVIEPEDEPTTFRNPLEALLSTGQYSVVSSDEDVESVRDPDDGTLPIHSTQTVEEPIDTKAGEKLTDSSKQPSPPVAEHFSNETFSASPKGAETDVKSEGSNNHEQGSFNEPKSNVDSNDSASPKRPSSQASLRHNVTVEEVPDEDA
Protein: SD10846p (Vacuolar protein sorting 45) (Q9VHB5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD29542p
- Syntaxin 16
- LD27967p
- HL02043p
- LD23667p
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 39 homolog
- GH24245p
- Endoplasmic reticulum-Golgi intermediate compartment protein 3
- Vacuolar protein sorting-associated protein 8 homolog
Sequence:
MNLISGIKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLKYLKCIVFIRPTKQNIQLLANELRNPKYSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADYLCVNPNLFSLGIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYEQITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVPKDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQRKANDHKKVESIADMKNFIESYPQFKKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQLQRIKKLIADERVSIDDALKLVALYALRYERHANCDTSGLLQIIKTRGGRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKLTRNLIKGLKGVENVFTQHTPLLKETLEDVFKGRELDPLFPAINSELVPFRRPPQEVVVFIIGGATYEEALAVHQLNNAGYKVILGGTTIHNSQSFIQEVVAATSGIQFKHTKSMIKYCSTDNI
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q38CP6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MTQTSKRRPVLYQMLLAILSLISTSAPTMGTQEALKAKGFDDSCKIANELMKYGSYAETITKTLTSHLFEVETILHDIKKLMKSGTLARNDDNINLLMHTRTTVDEAKAAVRTHLAAAIDAGNEGAFVAGAILETTHLFFAANNGGSNYCMSNDGAGGRAAINDIPDCKDRDAVRRTFKKEAVATLTGAQHALTNFGTGGDGSKGVDATKSCRLSATDGTNGVMGAGGGTAPTIYLMAGLLKLTGSVPAATSWSTGHPLETNNPITKVKALKPTCTASLDAATAALGQLTTLGSADPNPTFKAITTTEAKLGLGDTEQTVEISVPTLKAAHKAIKKLRGDAVTASGKSTETTKRAQLTQEITPPPPPTECNPITTEGGCNEIKIEADCNATAACSFNKTETDENKKCKLDTEKAKKKSVSVTQAQTGGPETTTEKCKDNKSEAVCKDGCKWEGTECKDSSILVNKKIALIVSSFVGFVEF
Protein: Butyrophilin subfamily 1 member A1 (BT) (Q62556)
Organism: Mus musculus (Mouse)
Function: May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.
Subcellular location: Membrane; Single-pass type I membrane protein. Note=Secreted in association with the milk-fat-globule membrane during lactation.
Interaction partners:
- Xanthine dehydrogenase/oxidase
- Periplakin
- Perilipin-2
- Beta-casein
- Alpha-lactalbumin
Sequence:
MAVPTNSCLLVCLLTLTVLQLPTLDSAAPFDVTAPQEPVLALVGSDAELTCGFSPNASSEYMELLWFRQTRSTAVLLYRDGQEQEGQQMTEYRGRATLATAGLLDGRATLLIRDVRVSDQGEYRCLFKDNDDFEEAAVYLKVAAVGSDPQISMTVQENGEMELECTSSGWYPEPQVQWRTGNREMLPSTSESKKHNEEGLFTVAVSMMIRDSSIKNMSCCIQNILLGQGKEVEISLPAPFVPRLTPWIVAVAIILLALGFLTIGSIFFTWKLYKERSSLRKKEFGSKERLLEELRCKKTVLHEVDVTLDPDTAHPHLFLYEDSKSVRLEDSRQILPDRPERFDSWPCVLGRETFTSGRHYWEVEVGDRTDWAIGVCRENVVKKGFDPMTPDNGFWAVELYGNGYWALTPLRTSLRLAGPPRRVGVFLDYDAGDISFYNMSNGSLIYTFPSISFSGPLRPFFCLWSCGKKPLTICSTANGPEKVTVIANVQDDIPLSPLGEGCTSGDKDTLHSKLIPFSPSQAAP
Protein: SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (Q9NP31)
Organism: Homo sapiens (Human)
Function: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
Subcellular location: Cytoplasm.
Interaction partners:
- Vascular endothelial growth factor receptor 2
- Proto-oncogene tyrosine-protein kinase Src
- Tyrosine-protein kinase Lck
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Tyrosine-protein kinase ITK/TSK
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- DNA repair and recombination protein RAD54B
Sequence:
MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
Protein: RNA-binding protein 39 (Coactivator of activating protein 1 and estrogen receptors) (Coactivator of AP-1 and ERs) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Q8VH51)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing (By similarity). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DDB1- and CUL4-associated factor 15
- Protein SON
- RNA-binding protein 25
- RNA-binding protein 5
- Probable ATP-dependent RNA helicase DDX5
- Splicing factor U2AF 65 kDa subunit
- Luc7-like protein 3
- Serine and arginine-rich splicing factor 11
- Serine/arginine repetitive matrix protein 1
- Splicing factor 3B subunit 1
Sequence:
MADDIDIEAMLEAPYKKDENKLNSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLLVPSRR
Protein: C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) (O88680)
Organism: Cavia porcellus (Guinea pig)
Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Complement C3
- Complement C5
- Anaphylatoxin-like domain-containing protein.
- NTR domain-containing protein
- C5a anaphylatoxin chemotactic receptor 2
- Complement C1q subcomponent subunit A
- C5a anaphylatoxin chemotactic receptor 1
- Pro-opiomelanocortin
Sequence:
MESSSAETNSTGLHLEPQYQPETILAMAILGLTFVLGLPGNGLVLWVAGLKMRRTVNTVWFLHLTVADFVCCLSLPFSMAHLALRGYWPYGEILCKFIPTVIIFNMFASVFLLTAISLDRCLMVLKPIWCQNHRNVRTACIICGCIWLVAFVLCIPVFVYRETFTLENHTICTYNFSPGSFDYLDYAYDRDAWGYGTPDPIVQLPGEMEHRSDPSSFQTQDGPWSVTTTLYSQTSQRPSEDSFHMDSAKLSGQGKYVDVVLPTNLCGLPMEENRTNTLHNAAFLSSDLDVSNATQKCLSTPEPPQDFWDDLSPFTHEYRTPRLLKVITFTRLVVGFLLPMIIMVACYTLIIFRMRRVRVVKSWNKALHLAMVVVTIFLICWAPYHVFGVLILFINPESRVGAALLSWDHVSIALASANSCFNPFLYALLGRDLRKRVRQSMKGILEAAFSEDISKSTSFIQAKAFSEKHSLSTNV
Protein: Nuclear transcription factor Y subunit B-4 (AtNF-YB-4) (Transcriptional activator HAP3D) (O04027)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the NF-Y/HAP transcription factor complex. The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Nuclear transcription factor Y subunit C-1
- Nuclear transcription factor Y subunit C-7
- Nuclear transcription factor Y subunit C-8
- Nuclear transcription factor Y subunit C-9
- Nuclear transcription factor Y subunit C-2
- Nuclear transcription factor Y subunit C-6
- Nuclear transcription factor Y subunit C-4
- Nuclear transcription factor Y subunit C-10
- Nuclear transcription factor Y subunit C-5
- Nuclear transcription factor Y subunit C-3
Sequence:
MTDEDRLLPIANVGRLMKQILPSNAKISKEAKQTVQECATEFISFVTCEASEKCHRENRKTVNGDDIWWALSTLGLDNYADAVGRHLHKYREAERERTEHNKGSNDSGNEKETNTRSDVQNQSTKFIRVVEKGSSSSAR
Protein: Nucleoplasmin (Nucleoplasmin-2b) (B2CQD3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSKTEKPLSTLWGCELNESNKEESFKTDDTNHQHQLALRTMCLGHTAKDEFNIVELVTGEGNSNAKAVPIATLHAKSMPTVNLSGLDLHPPVTFRLKHGSGPVFVGAEHVALEEYSDEEELDEEMDEEVEEEEEDIEESPVKKVTKNSAGKRKKPEKGEDEEASDGENPPKKGKGRGRKAKA
Protein: Fibrinogen-like protein 2 (Q8MIP7)
Organism: Sus scrofa (Pig)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKLKLSNWCWLSSAVLAAYGFLVVANNETEEIKDEAAKDACPVRLESRGKCEEVGGCPYQVNLPPLTLQLPKQFGRIEEVFKEVQNLKEIVNSLKKTCQDCRLQADDNRDPGRNGLLSPGTGAPGEADDSRVRELENEVNKLSSDLKNAKEEIDGLQGRLEKLSLVNMNNIENYVDNKVANLTFAVNSLDGKCSSRCPSQEQIQSRPVQHLIYKDCSEYYTIGKRSSEIYRVTPDPKNSSFEVYCDMETMGGGWTVLQARLDGSTNFTRTWRDYKVGFGNLRREFWLGNDKIHLLTKSKDMILRIDLEDFNGIKLYALYDHFYVANEFLKYRLHIGNYNGTAGDALRFSKHYNHDMKYFTTPDRDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYNQKYRGVRNGIFWGTWPGISEAQPGGYRSSFKEAKMMIRPKYFKP