wanglab/gogpt-training-data huggingface dataset:
Protein: Testis-expressed protein 19.1 (mTex19.1) (Testis-expressed protein 19A) (Q99MV2)
Organism: Mus musculus (Mouse)
Function: Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and preventing their mobilization. With its paralog, Tex19.2, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent meiotic recombination. Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18802469}. Note=Was initially reported to localize in the nucleus (PubMed:18096721). However, it was later shown to localize in cytoplasm only (PubMed:18802469). Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:18802469). {ECO:0000269|PubMed:18096721, ECO:0000269|PubMed:18802469}.
Interaction partners:
- Deleted in azoospermia-like
- E3 ubiquitin-protein ligase UBR2
Sequence:
MCPPVSVRHGARGMSCLYEAWLYHLVHGEQTKICFACFKAAFLLNKLYLEMGDWQEEEEEEEEEDADLLEYLSESESESEQEPGPEQDAWRGLGSLYVPQSVSEGSGVLLPTPVWTQGILFSIFVPTELFPQEAVPLDLGPEDAEWTQALPWRLDGLFPCSHQLIPPLTWWDIFDVMPSPGQPVLLELRCHWPLDQTVAQSWLQDQKFVLLLDSVQSRCHLLSMRVRWVVRTQVQHWQVLLDPGEMWVAHFRKEVGQHGLYHQSLNPWRLSILTASELGMELLPATCYLWNKGFWVGSFLPWHINMPETWSWEPGERLFITDATICGTDYHLAQSFLDSHPTPHPLLTLTP
Protein: Tear acid lipase-like protein (TALLP) (Q3YBN2)
Organism: Mesocricetus auratus (Golden hamster)
Function: Female-specific protein which lacks detectable lipase activity against a range of substrates. Binds the hydrophobic lipid 1-aminoanthracene with high affinity.
Subcellular location: Secreted {ECO:0000269|PubMed:17141562}. Note=Secreted by the female lacrimal gland into tears. {ECO:0000269|PubMed:17141562}.
Interaction partners:
- Acylglycerol transacylase
- Acyl carrier protein
- Partner and localizer of BRCA2
- Patatin-like phospholipase domain-containing protein 2
- Hepatic triacylglycerol lipase
- Endothelial lipase
- Monoglyceride lipase
- Hydroxysteroid dehydrogenase-like protein 2
- long-chain-fatty-acid--CoA ligase
- Triacylglycerol lipase
Sequence:
MSWLLSTMCLVHVCGNIFCLFETTTNPEAYMKVSKIVNHWGYTSEEYEAVTEDGYILPLNRIPHGKNNINSTAPKKVVLCQHGLFSTAGVWVSNPPSNSLAFILADAGFDVWMGNSRGSTWAKKHLYLDPNSKEFWAFSFDEMIKYDLPATINFILKKTGQKQIYYIGHSQGALIALGAFSTNQKLAEKIKLCFLLAPIATLKHVEGIVSLLPYFYPTAFKVVFSEKEFLSAVAFSKLHGYSCNAKVINDGCVAIFLSMTGYVPQHLNKSRVDVYIRHSLAGTSVQTLLHYRQAIKKGVFEAYDWGSQSLNMLHYNQTTPPLYNVEDMKIPTAMWSGGKDSLADTKDVAHLVPKISNLIYHKITADFSHLDFTVGKNAYYVSNDILKLLDKSETENLH
Protein: adenylate cyclase (EC 4.6.1.1) (Q9VK53)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ras-like protein 1
- cAMP-dependent protein kinase catalytic subunit 1
- cAMP-dependent protein kinase catalytic subunit 2
- IP06402p
- Bis
- Inosine triphosphate pyrophosphatase
- LD28489p
- Molybdenum cofactor biosynthesis protein 1
- GTP cyclohydrolase 1
- 3',5'-cyclic-AMP phosphodiesterase, isoform I
Sequence:
MSFPRTNSRKSPLKRKRLRPCHLDYANERLWEHSYLREKCKELNLEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKNDWPLNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQYIHTYLLTGQVARESFITSIGGVRSSSVLEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVCWWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYIESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKHELYYENYRMVSVMFAMLINFPMNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFVGIDENLKFMSAKLVNRSLSRRFSVMSSLDPDSLRKSSSSDQESGE
Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (A0A1D8PJN3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Membrane {ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362033}.
Interaction partners:
Sequence:
MSESKDQSTDSTGSPGLQSRGEPQPPSFKEKIHRFFFLKGLADRPPYLQEIYDNTPRTVFYNYDLPDYMIDSQGRPITQYPRNKIRTTKYTPITFLPKNLLLQFTNVANSYFLLIVILGAFQIFGVPSPGLAAVPLIVIVCITAIKDAVEDYSRAASDAELNNSPIHLLTGVHNPNVLVDQVGPWRRFKKACSRGTARVFKFIKKCCIFICGSKRVKQEYAREQVQEDNLALHRVSTVVSDYTYRSQEPRYSVSSPRRSMNTNRRSIQSSHHRPTVALPNSLLNPILKKENAQNPSSIRANFKNRCWKDVNIGDIIRIRANEEVPADVIIISTSDSEGNCYIETKNLDGESNLKTRTALKCGGNNNLKHSDDLSDTKFWVECDAPNANLYSFKGTIHYENFDSKGNLVNEDEKEAITPENVLLRGCTLRNTKWVIGFCIYTGPETKIMLNSGITPTKTSRISRELNLSVIINFILLFVLCFVSGLINGLFYRNENNSRVFFDFHPYGKTPAINGVIAFWVALIIYQSLVPISLYISIEIIKTIQAYFIYADVKMYYDRLDFPCIAKAWNISDDLGQIEYVFSDKTGTLTQNVMEFRKCTINGKSYGLAYTEAQQGLDKRAGIDVIENANKWKNKIAADKEVMMDDLTKYSNNDQLREENITFVSSQYVRDTFLGDSGDDQKQANERFMFALALCHTVMTEESESDSTLRDFKAESPDEAALVSVARDMGIVFKKRLRSSLLLEIYGEEQEFHLLDIIPFTSARKRMSCVIKTPDNKIILYTKGADSVIFQRLNPRENPNELVSKTALYLEDYANEGLRTLCIASKVLDPQVYDNWNKRYREASSSISDDREVLMGQLEEEIEQDLVLLGGTAIEDRLQHGVPQSISILSEAGIKLWVLTGDRVETAINIGFSCNLLENDMKLLVVRPESNDTQDCEQIDDLITKYLQEEFHIDASSPSLVADAIKQARKDHSIPQAKVALVIDGAALSLIFQDLKDCPNDTIRVLQDKFLLLGKQCRSVLCCRVSPSQKAQVVKLVRTGLQVMTLAIGDGANDVAMIQAANVGVGIAGEEGRQAVMSSDYAIGQFRFLTRLLLVHGRWSYKRLAEMIPCFFYKNVVFTLTCFWYGIYNNFDGSYLYEYTYLMFYNLAFTSLPVIVLAVFDQDVSDTISLLVPQLYTSGILGKDWSQYKFVWYMFDGLYQSVISFFFPYLLFYLAFQNPQGMTIDHRFYMGVVAACIAVTACDIYVLMQQYRWDWLSVLIDCISILLVYFWTGVWSVNATYSGEFYRAGAQTLGTLGVWCCIFIGVIGCLLPRFTFDFFTSNFKPADVDIIRERVRQGAYDDYPLGYDPTDAEDVERHRLLTEIINKDPQLFEKMENEYKEEEHDKETPLERTFKSIKRRTTISRSKKGTAQRLRRDTINDQFQKHIPLDELRQQMIKEGEYTSARYSLDRINTTHEIPGVTQADTLLKYHTRNSVALNP
Protein: Uncharacterized protein (Q38DV1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEQQQQQPEEKKEGGEWYKYLITIAVYIGLTALWIVGCLIHKRSVARRQAAGVAQSAKGRTESNDNGNTSNEHKKEEAANNNPSNNQQTSQYPTYDFSSNQNREYGTDAYYSNSYDTNNNASNENRRDYRM
Protein: Homeobox protein Meis3 (Homeobox transcription factor Meis3) (Myeloid ecotropic viral integration site 3) (Q90ZE3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Homeobox protein Hox-B1b
- Homeobox protein Hox-B1a
- Homeobox protein Hox-B2a
- Homeobox protein Hox-B5b
Sequence:
MDKRYEELVQYPGSDAMPVGGYRDTMRSLPPPHYGHTVPDSLKHHRDQIYGHPLFPLLALVFEKCELATCSPRDSTSMSNPAHLPGMTNHSDVCSSDSFNDDIAAFAKQIRSEKPIFSSNPELDNLMIQAIQVLRFHLLELEKVHDLCDNFCHRYITCLKGKMPTDLVLEDREGGSKSDMEDFTGSCTSLSEQNQSWLRDPDDCVSTPSGTPSASCGLNSHSVENCSDAGDGLDGSVASPSTGEEDESDRDRRNNKKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLSQDTGLTILQVNNWFINARRRIVQPMIDQTNRSGQSAPYSPEGAALGGYGLDAQSHLGLRTAGLQGLPSLPTDYPGALLPQPGYSHAGPSLHPYPGPHTAMLLHPPPHSHPSETLIGQGLDIHAH
Protein: Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C) (EF-2) (P70180)
Organism: Mus musculus (Mouse)
Function: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P17342}; Single-pass type I membrane protein.
Interaction partners:
- Natriuretic peptides A
- Natriuretic peptides B
- C-type natriuretic peptide
- Neuronal pentraxin receptor
- Osteocrin
Sequence:
MRSLLLFTFSACVLLARVLLAGGASSGAGDTRPGSRRRAREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWRRGDKHDSEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFQMRSNVKYPWGPLKLRLDETRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNQQEESNIGKHRELREDSIRSHFSVA
Protein: Y' element ATP-dependent helicase protein 1 copy 1 (EC 3.6.4.12) (P0CX20)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Interaction partners:
- Putative UPF0479 protein YDR545C-A
- Putative UPF0320 protein YDR543C
- Putative uncharacterized protein YDR544C
Sequence:
MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVISVMVGKNVQKFLTFVEDEPDFQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEIASARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDTNGVAMWKWIKILYHEVAQETTLKDSYRITLVPSSDGISVCGKLFNREYVRGFYFACKAQFDNLWGELNNCFYMPTVVDIASLILRNREVLFREPKRGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMVHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHDQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIIALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSAITTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE
Protein: Ran GTPase activating protein, isoform B (M9PBD9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTFNFASMAAQLGQEQGISFENKVLSWNTAADVQDVVDALNKQTTVHYLNLDGNTLGVEAAKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAFQTLKTFEEIVLEQNSIYIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEINSDGGLVLVNAMGNKPKLRILNLDGNSFGEEGSEKIISEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEEEEEVHEHANDTTEEADEDSEGDEDDEEDEGDEEYSNVAEETAYVTTNAYTTKLFNDTTNSMASETFAVANKTISQKCTPEKFCLSQKPCSQEDFDSLDMDNKLEALQSIVNQFTGDNHLLLLVFTTLKCAHLSQSSKAALDLAVSLYQATFDYAIKTKQETRVLNYVLMQLRLLPCKEVFHSDYDVKNCRFALREALKQPTFANDNIKNSFKTFLEGAES
Protein: Pre-mRNA-splicing factor dre4 (DNA replication protein 4) (Hyphal growth protein 1) (Q09685)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the spliceosome involved in mRNA processing.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- U2 small nuclear ribonucleoprotein A'
- U2 snRNP component prp10
- Pre-mRNA-splicing factor sap114
- Uncharacterized protein C1782.03
- Spliceosome-associated protein 49
- Pre-mRNA-processing ATP-dependent RNA helicase prp11
- Pre-mRNA-splicing factor cwf2
- Small nuclear ribonucleoprotein Sm D1
- WW domain-containing protein C2F3.14c
- Pre-mRNA-splicing factor prp12
Sequence:
MSQPLPPGWTEHKAPSGIPYYWNAELKKSTYQRPSFIEKNHSSSVTASQASLAFNTSEKLFVNENAEERKNSRDLRKQLPDRPKFKKRIPNNDSWVVVFTKKNRYFFHNLKSHESYWEPPLEISKDLKILRLPIRKQISKDSSQSQNVDSGKTNHEEIHESRHLQTEIEEPSGLEESSEESVLYSEEFYEKSDEEEDEEKSHSAEELEFGEEDIMYQLQQLDDETVSYDIQEQATNLSTDDARRVFTELLKDKNIGAYQPWELVYPKLLDDDRFYVLDSGERRKEVFEEYCKSVVSTKKITRRKNTLSDFWTLLHSLPSTLLWPQFKRKYRKSSTLQIPGYSERDFEKLFREFQILRKQPMQDKLLNFKKLCKSKTVDPKNPDEFTESILNDTRYAVLTREELDSLACSSN
Protein: Homeobox-leucine zipper protein REVOLUTA (HD-ZIP protein REV) (Homeodomain transcription factor REV) (Protein AMPHIVASAL VASCULAR BUNDLE 1) (Protein INTERFASCICULAR FIBERLESS 1) (Q9SE43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in the regulation of interfascicular fiber (cortical cells) and secondary xylem differentiation in the inflorescence stems. Required for lateral shoot meristems (LSMs) and flower meristems (FMs) initiation. May be involved in the determination of vascular patterning and organ polarity. Directly regulates the expression of AGO10, ZPR1, ZPR2, ZPR3 and ZPR4. Required to regulate adaxial-abaxial polarity and leaf axial patterning.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10559440}.
Interaction partners:
- Protein LITTLE ZIPPER 3
- Pentatricopeptide repeat-containing protein At5g25630
Sequence:
MEMAVANHRERSSDSMNRHLDSSGKYVRYTAEQVEALERVYAECPKPSSLRRQQLIRECSILANIEPKQIKVWFQNRRCRDKQRKEASRLQSVNRKLSAMNKLLMEENDRLQKQVSQLVCENGYMKQQLTTVVNDPSCESVVTTPQHSLRDANSPAGLLSIAEETLAEFLSKATGTAVDWVQMPGMKPGPDSVGIFAISQRCNGVAARACGLVSLEPMKIAEILKDRPSWFRDCRSLEVFTMFPAGNGGTIELVYMQTYAPTTLAPARDFWTLRYTTSLDNGSFVVCERSLSGSGAGPNAASASQFVRAEMLSSGYLIRPCDGGGSIIHIVDHLNLEAWSVPDVLRPLYESSKVVAQKMTISALRYIRQLAQESNGEVVYGLGRQPAVLRTFSQRLSRGFNDAVNGFGDDGWSTMHCDGAEDIIVAINSTKHLNNISNSLSFLGGVLCAKASMLLQNVPPAVLIRFLREHRSEWADFNVDAYSAATLKAGSFAYPGMRPTRFTGSQIIMPLGHTIEHEEMLEVVRLEGHSLAQEDAFMSRDVHLLQICTGIDENAVGACSELIFAPINEMFPDDAPLVPSGFRVIPVDAKTGDVQDLLTANHRTLDLTSSLEVGPSPENASGNSFSSSSSRCILTIAFQFPFENNLQENVAGMACQYVRSVISSVQRVAMAISPSGISPSLGSKLSPGSPEAVTLAQWISQSYSHHLGSELLTIDSLGSDDSVLKLLWDHQDAILCCSLKPQPVFMFANQAGLDMLETTLVALQDITLEKIFDESGRKAICSDFAKLMQQGFACLPSGICVSTMGRHVSYEQAVAWKVFAASEENNNNLHCLAFSFVNWSFV
Protein: Capsid protein VP10 (A0A1W6I162)
Organism: Sulfolobus polyhedral virus 1 (SPV1)
Function: VP10 self-assembles, together with capsid protein VP4, to form an icosahedral caspid of 87 nm in diameter, with a T=43 symmetry and composed of 420 hexamers and 12 pentamers. VP4 proteins arrange into hexons, while VP10 proteins form the pentameric densities located at the 5-fold axes in the virion. The stoichiometry of VP4:VP10 is 42:1.
Subcellular location: Virion {ECO:0000269|PubMed:31636205}.
Interaction partners:
Sequence:
MLSLDNYSYVHNITTQTNIDLSSQQTIHLASINGKGYIIFLRFFCEGSSACFTNVKFSVKANGLVLYSFRYIQLLELGQAIATAIPSSSQGFSTLLSNYNVLISSPIGTLPQLTLYDSYDNRYGAMLQPAFPLPFVNTLSLDVDILPVSQSSYDPIPYSLNDNQISTNAPTGKGNISIEYLLYNCLV
Protein: Protostome-specific GEF, isoform H (M9PGV0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPTMTRMHRHSSSSAVVEESRGRRRGVGVPGVGDANKENFGVHFMSSPFGNASLIALQDLSNVHGKSPQRRSFSEGSGPRQATPQLAALRCLPRTTGGAVALEDSQLSSSRMGDTTLDRMLDAIIESARKEVRCTKTLPGAGATTSTTILADNAEWSETSVHEMEVRTPTHLKRQRVVRRKNPHKTTTINQTQSHQAKKLEPLQLVPSTKRCLSFSSSSASSDLDEDEQQVAKRSSLASPTTTPPSHCTTTTSSISSSSSSNGGADMEASQRGSIDVSIAFDAKEQQLNVHVIRCRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGSMSSGYQRTAVHRHSGRPYFDQRFNFQISSGEETAGQYLQLAVWHRDRHLKRSEFLGCSTFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISIDSMGKEDPLLPQQPQQPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQATGSQSSASKANESNANHLNNGTSGGRRQSTMPNSGGSSVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWTHPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIFRRSGAGATTITSTDLGQNNVHISTRLGAAVGLGSEEHTLATTATGTTTVMSLQRTTSTRIQPLANSMSRPATACSGTTSSIEAAKRRLHLPQVTFSKESIVPVTDNRRRFLLQLISREQNFTAALHFGVDRFVQPLGERKDLISPNDHRTLFQNIDELLRIAEDILEQLCSSDQQDQEPQMNFASRVYLSKTTAICAAYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAVPRKRPDLTMFIHRPLQHFREILKLMQLLAGNCHVDTEEHKNFSTVINELQAAYREITVSSGLMEPLGEGRPLLTLQDLESRMVFTKCKPFTLAVQGRQWIFGGDLSRVEGRSVKPYWTLLFSDIIVFAKVSRDRVLFITEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAESPTGYCAPDLTRTPKRGARRKSLILRAPSLELKAVWQNLLQRQIFLVNAALGSTPLSSPLDSPDVLNTLVPLSDIGLTTASMGSMKLPSLDSIHLKQQQKQQRTNNSHGHVHSATGVATDRTADRSHGHNHGIHGGHVEQIELLIDEKCRILNKTGTPKSSALHLANWMKGQLDKQQQQARLAAIARSQENVSAEDEQLIFNSDSEQDERITYWTRQQLEKRTKELNLAKENGGLSARPNFGGKRLSGVEELSMSATSDIYSTSEAEGVTSVISQSHSTTSDSQITVRSSPIVLDKLAVCRHCHKNCQQSGPGGARPGGGGGVNNSSSTPVLLCNSLKVQHSQSSPNRCCKLSNGIAGATEMANPKNSNRTGTGTGSVTSMSSSTITGELSSKVVASSSRRETGDTESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSLPNGHCSAGVGGGSPKPLPPPRRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGGSPAKYAACHCRCTPEDFTHAQLSPDKMEHQTCKLLESPKQTTTTLEQKQEDEQLSLMLIGLAQLAPAATLCGQERIPKEENSTPTIAVVPPTPDSVLTKTSTHVWDNSGCSSNGGGTSTTSTATTTTKQPRQAIIENIPEDSCDESPLDEEPPYRPMSSALRRFGTMSSLEKLPSDDRMDEADELDDDLDSFKPNGHDGNSPQNEEDDEDADSERALVQNDLGASSSSGVIVNGEGLASGAWTNRAGAYVSDKMSFFEESRAFIDKYLGRWNAGDAQQQHQQGTASETDEQMDECTSGATSGEEVWGTPTSGGDNDDQDLQLINSENTHSSPTKSSTSLNDDDDTELMMDELLMAPPMTASTIRGLLPRGKQRPMATT
Protein: Glucose-6-phosphate 1-dehydrogenase X (G6PD) (EC 1.1.1.49) (Q00612)
Organism: Mus musculus (Mouse)
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P11413}. Membrane {ECO:0000250|UniProtKB:P11413}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11413}.
Interaction partners:
- 6-phosphogluconate dehydrogenase, decarboxylating
- 6-phosphogluconolactonase
- Glucose-6-phosphate isomerase
- GDH/6PGL endoplasmic bifunctional protein
- Cellular tumor antigen p53
- Hexokinase-3
- Hexokinase-2
- Pyruvate kinase PKM
- Glucose-6-phosphatase 3
- Hexokinase-4
Sequence:
MAEQVALSRTQVCGILREELYQGDAFHQADTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPEDTFIVGYARSRLTVDDIRKQSEPFFKATPEERPKLEEFFARNSYVAGQYDDAASYKHLNSHMNALHQGMQANRLFYLALPPTVYEAVTKNIQETCMSQTGWNRIIVEKPFGRDLQSSNQLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPATTGSDDVRDEKVKVLKCISEVETDNVVLGQYVGNPNGEGEAANGYLDDPTVPHGSTTATFAAAVLYVENERWDGVPFILRCGKALNERKAEVRLQFRDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHKIDREKPQPIPYVYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
Protein: RNA-binding protein, putative (Q387J8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEPECESFPVGEAAPASTSSPFISTQMPPPMTSAPQLPSNEAEAPEGSKQHLSGGLTPRAAPFAAPRPSFSMEPEPLRNLIVNYLPPMMDEDRLFQLFAQFGPIESVKIIYDKVTRESRGYGFVKYMYFFSATYAVQWLNGYPIAGKRLKVAFANAEAAMESYKAMSASAMMFTMQQQAAMQNIFQRQMFLAQQQQQQQN
Protein: Glutaredoxin-1 (Thioltransferase-1) (TTase-1) (Q9ESH6)
Organism: Rattus norvegicus (Rat)
Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular location: Cytoplasm.
Interaction partners:
- Thioredoxin
- Ribonucleoside-diphosphate reductase
- Glutathione reductase
- Thioredoxin reductase 1, cytoplasmic
- Thioredoxin reductase 2, mitochondrial
- Glutathione peroxidase 1
- Glutathione peroxidase 3
- ribonucleoside-diphosphate reductase
- Ribonucleotide reductase M2 polypeptide.
- Glutathione peroxidase 2
Sequence:
MAQEFVNCKIQSGKVVVFIKPTCPYCRKTQEILSQLPFKRGLLEFVDITATNNTNAIQDYLQQLTGARTVPRVFIGKDCIGGCSDLLSMQQNGELTARLKQIGALQL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (G3V9Q4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- MOB kinase activator 1A
- Cell division cycle 14B
- Dual specificity protein phosphatase CDC14A
Sequence:
MWAGRRRARAVPLPGKRRRRVAHAQCRPQRPLSPQSEGVTGEPWPLRAAVFSGSWGSSCCPLPSRLGSRAPSASPARRGRSRAARSSRLCRLCRRRPRASLPPGSVFSGSFSLCSPGCPGCPGTPPPGLVELFAMAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVRMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPVSEKAKGLILRFCCEWEHRIGAPGVEEIKSNPFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVTTSNHPETDYKSKDWVFINYTYKRFEGLTARGAIPSYMKAAK
Protein: Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) (P58197)
Organism: Rattus norvegicus (Rat)
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and c-Myc. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- BTB/POZ domain-containing protein KCTD1
- Protein DEK
- Transcription factor AP-2 beta
- Nucleophosmin
- Cellular tumor antigen p53
Sequence:
MLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHGLGSGLGDLPIHSLPHAIEDVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSSPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVARKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSAKSSDKEEKHRK
Protein: Heat shock protein 90 homolog (P46598)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Co-chaperone
- Hsp90 cochaperone
- Hsp90 co-chaperone Cdc37
- Transcription factor SKN7
- Hsp90 cochaperone
- Heat shock protein HSP70
- Heat shock transcription factor
- Aha1p
- Chaperone ATPase
- Peptidyl-prolyl cis-trans isomerase D
Sequence:
MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKEVPETEEEDKAAEEDDKKPKLEEVKDEEDEKKEKKTKTVKEEVTETEELNKTKPLWTRNPSDITQDEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDDAEELIPEWLSFIKGVVDSEDLPLNLSREMLQQNKILKVIRKNIVKKMIETFNEISEDQEQFNQFYTAFSKNIKLGIHEDAQNRQSLAKLLRFYSTKSSEEMTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKNFEVLFMVDPIDEYAMTQLKEFEDKKLVDITKDFELEESDEEKAAREKEIKEYEPLTKALKDILGDQVEKVVVSYKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPSSPIIKELKKKVETDGAEDKTVKDLTTLLFDTALLTSGFTLDEPSNFAHRINRLIALGLNIDDDSEETAVEPEATTTASTDEPAGESAMEEVD