Protein: Sex determination and dosage compensation protein sdc-2 (G5EBL3)
Organism: Caenorhabditis elegans
Function: Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reduction of X-linked gene transcription and an equalization of X-linked gene expression between the sexes. May confer protection against toxicity induced by heavy metals such as arsenite.
Subcellular location: Chromosome {ECO:0000269|PubMed:10364546}. Note=Localizes specifically to X chromosomes in hermaphrodite (XX) embryos. {ECO:0000269|PubMed:10364546}.
Interaction partners:
- Zinc finger protein sdc-3
- Zinc finger protein sdc-1
- Dosage compensation protein dpy-30
- Lysine-specific demethylase 9
- Chromosome condensation protein dpy-27
- Mitotic chromosome and X-chromosome-associated protein mix-1
- Condensin complex subunit dpy-26
- Condensin complex subunit 1
- XO lethal protein 1
- Condensin complex subunit capg-1
Sequence:
MSDESELGNQSEMESFNESDSPDEADPDVVIIHDIVHLRASTTGDYSQSEIGKLPEQNTFFLPGRVKRNISSNDSDVIIDEDEIPDGAIRITSDTHFIGSSRGTSELGDFEMDEQEFLNITIEENGNEQELEEHLRNAYRHEEEECFEEEDDIIELPPLPVKPAVKKPRRKLPKHLSIESGSTAKTSKLVAEVVHDHPRPVNYRMKPAVTDDGKVVEQKRTRVTRNIMSHTIPQYHLEGEETEFGRVKESTLSKTIEQYLQAGKLVSPKCDQFREQIVATAVEYDGSVKMLQFENALKKHSGKQKRLKYQTGWWKASKSHYERAVNGYVAMPKTPVLSISDDPVLYKHHSLFPKNQSSELEKINVQLRIRLNSKRQNNDVIPDSSYFVREFLMQKHSISLRMNRSSDLPELFVPPTLECGYFPQDAVTVQQQEHYLMMRFEEAQDEYHNITYRSIAPPVEFQVGTISAKELHKFHRIGRHIHGFFVVWENKFPEYDESGICCPRKRYLVDMFNLICFPLYTEYEQWESRLRVAFDKTIVYNLHLSEILRCNRPVFDFLSKNKSMLQPITLKEIVYLIEQSNMDAKSFAVKFGLRTFYDHGRATSNKDYLSAFLIITGGAKVVTEEIDSERLRVFNSDYMESGVLTSSGDVYTFEFDKIPNNYQISIGCNADGVAEMEQEDVRHELSECSSRITRIIGDSKKPEKIIARPLVKTNQNDGMKFFTRKDLLNYRIKLYDPSYVVPRAKKQIVNEPAKKKPGRKSKTRYDAAMQQNNFEIEGVPSDVDSEFEGYLSDSENVFQKPSKLMRSTSSDSVFIDYQYREKMFLDVSWFHQQKMIDRSLPPLKKRKRKMNRIYHKHSVRYTMLQANGCAFTEMYRCYDKILPCGTKEIARTKNAIRFPHRFRTYNIPQVYGPGDKQLITEVFGVVKDVITRATGFESASIRTANDIAQAVYDANIARRELLENLEPSDNGILPSPAYLAIEMLSHQKMSGRLCLESARKDVQNNVDKMYNDYMDLDPLDKELHFEISQSIRQSKLNESLEEYERNRERQLAKTLKTVPMDKRSQAALARREEKRRESRRKLADKYAEQRRMMASTRRLEKRTTQKQVDPETIQRLRREDEVRKRKRFEEEDRRGMIRRREERVALQEKVDRMLEEGLRLEKVREAERIRQQQEEERIEMETILISRRVREEEEEKMRLERLRKAEREREQERLKREEEEERKRLEQLREAEKLKAEIEKENERKLQEERTRKALELERKIEEIKRVSTLKDMFGPLPIAKENEQTEKDFQILLDDHELTLLTISRDPLNEKYQEARTEFERLDIKSMLLRKAEKLIDVLTIHYDVPIEQTCRYFTSSIESNENRMAVNEQLNKLFENMANCFTFNIQDGENGLQSKRKWDFQFKKCAVFDGVSQSTVNFIEEKMRENTKKKHLATPKTVISIDTSLLKQSLLRSHARFDPDISLYAQNHTANSIGDVTLKMSNYSLDFATQSIHDKELAEKATPKKGPTVRRHIKNLFGSEKVIVRRSLAAGKPASLNSEDSDSEDSREGSPVAEFLPTNPVCSFWKLVVKIENSTTDKEKTELCEDLDKLILRKDDLFSKSLKWMFPLLATFYVLLSNAVLNENEEIISDKNQTGVTKDEILKSTINDLMIIAAYFEEGSRERSNLRKMISMNGFSVVFNRVILFAKKTCTLAKELESNSRSLSGYVIEDLFESLLAEIERTMRQELGSSVRKTGKLERDFEEIVKLIQNEKKLALSHKSHKNDENRRFRLNTVVKWYDAIICHCKEELTQAIVDAFPLNAITKNKETSHVAMENGDDEAMLSDTSDNQMSTTDYQMPKNICRNSEIFPEDAFAKAYAVVRIPSKKERAQMLSVYRKKNAQSGCVENKGLSRMPKFEEPFVDSVWRTIEKRINNMTHSEEKQIKRFIPVSRSHKLNEKVKFYAMVMIQERDSRDTRLFNSKFQDDNLWHCYSKSSLNHEKMESRILQHIEHTVLSKSNFNQMKWSVQCVNGNKKDAIHYFTDLYKYRSESEFRSALSCGKLKFNFKVYTHLWFMGNLLPTSYNPDSHDDKLFVPCSGCTSGDVIIIHKCTCAYHNDTFSDKFIYANTSLPVGIDKVTRLVGRFVCEHGPSSFLILEHCSANVDANIPFESENVEFSAELRIVKRKTMHSQLVKTFAEEHTHLRDASRHRAISTVTLDSSGSGRSTRCEIFEDSPSEDENDENQLDTTRIGRKIDPIIVDSDKAYLIAEGERMALRIKRLLDPELQKFRSKNFVSRSKSVDAPKTSKQKTVIRRSQSVCDLNDVNEYAQKKVRNTKDSFATLFRDHEYSTRRTYEEQLNNELLDVVTTFGGASNVSADKKYNILASILAFEKEVQLVNDKNGELFKTVSNLVQRNSLQHVKGVILAEDNQTLRSTDNTSEVFPESKAVNEYLKFEIYKRKMMVNAKLMADTVKDLKLKHAEYRPFAKLIATYDSIFKFNVYLFEHFLNCISKHVFNPYAIYCEETRPTGTELSKFQLTLKLIETSMPTVLSMLFNTEPLRRQLSELSEIHKKVRSEDLACTIASLCRYAIERIRIPQTADKRLCDFSWLNSAEDHRETVSFIRLTLEHTLPDMKTENEQTRFVEFLKEAEGFHFSYKFVEAQCKTFVRNHGDSKQAFFTAFYNQNEAFYGSLQKFMSNGTIDPKMKLYYQHQAFLRLHNIVKKRSHIITSDDYHRSSDVCKAMLLSEIVSNPKIAQEAYISGSVLDRMYTSLCKIKAKMPLISPSYIGTSLTCFEDELLFSAVREAKVHTDTRVVFRSKSCMRPNEKAGDANFKTCKVTLLVNLETALLSMVFKSRDQSEIDKDDRLDIDILDEEVIKPIIDWNRIFETFIQPTYNTLFSRMEKRERVSILPENPLGRLENYAFTNPNQDKDCQAVLEYIDVASDTDAEESIEDPLDIVEMTLKRALPRSMSPSSKRRRMR