wanglab/gogpt-training-data huggingface dataset:
Protein: Probable histone H2A variant 3 (H2A.F/Z 3) (HTA9) (Q9C944)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. May replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- SWR1 complex subunit 6
- SWR1 complex subunit 2
- Histone H4
- SWR1-complex protein 4
- Actin-related protein 4
- RuvB-like protein 1
- Histone H2B.6
- Actin-related protein 6
- Transcription initiation factor TFIID subunit 14b
Sequence:
MSGKGAKGLIMGKPSGSDKDKDKKKPITRSSRAGLQFPVGRVHRLLKTRSTAHGRVGATAAVYTAAILEYLTAEVLELAGNASKDLKVKRISPRHLQLAIRGDEELDTLIKGTIAGGGVIPHIHKSLINKSAKE
Protein: Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1 (ARS consensus-binding protein ACBP-60) (Poly uridylate-binding protein) (Poly(U)-binding protein) (P32588)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be associated with hnRNA within the nucleus and remains associated during nucleocytoplasmic mRNA transport, once the proteins are in the cytoplasm, disassembly of PUB1-RNA complexes may occur prior to PAB1 binding and formation of a translationally competent RNP complex. Binds to polyadenylated RNA; prefers to bind poly(rU); binds to T-rich single-stranded DNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23222640, ECO:0000269|PubMed:8413212}. Nucleus {ECO:0000269|PubMed:8413212, ECO:0000269|PubMed:8413213}. Cytoplasm, P-body {ECO:0000269|PubMed:23222640}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23222640}.
Interaction partners:
- Polyadenylate-binding protein, cytoplasmic and nuclear
- Eukaryotic initiation factor 4F subunit p130
- Eukaryotic initiation factor 4F subunit p150
- Eukaryotic translation initiation factor 4E
- PAB1-binding protein 1
- RNA-binding protein SGN1
- Eukaryotic peptide chain release factor GTP-binding subunit
- Serine/arginine
- Heterogeneous nuclear rnp K-like protein 2
- Nuclear polyadenylated RNA-binding protein 3
Sequence:
MSENNEEQHQQQQQQQPVAVETPSAVEAPASADPSSEQSVAVEGNSEQAEDNQGENDPSVVPANAITGGRETSDRVLYVGNLDKAITEDILKQYFQVGGPIANIKIMIDKNNKNVNYAFVEYHQSHDANIALQTLNGKQIENNIVKINWAFQSQQSSSDDTFNLFVGDLNVNVDDETLRNAFKDFPSYLSGHVMWDMQTGSSRGYGFVSFTSQDDAQNAMDSMQGQDLNGRPLRINWAAKRDNNNNNNYQQRRNYGNNNRGGFRQYNSNNNNNMNMGMNMNMNMNMNNSRGMPPSSMGMPIGAMPLPSQGQPQQSQTIGLPPQVNPQAVDHIIRSAPPRVTTAYIGNIPHFATEADLIPLFQNFGFILDFKHYPEKGCCFIKYDTHEQAAVCIVALANFPFQGRNLRTGWGKERSNFMPQQQQQGGQPLIMNDQQQPVMSEQQQQQQQQQQQQ
Protein: Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT) (Q9NRA2)
Organism: Homo sapiens (Human)
Function: Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport. Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (By similarity). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva. Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (By similarity).
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:22778404}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:21781115}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:15510212, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:22778404}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
- Monocarboxylate transporter 4
- Lysosome-associated membrane glycoprotein 1
- Monocarboxylate transporter 3
- Monocarboxylate transporter 2
Sequence:
MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHHGHRH
Protein: CD83 antigen (mCD83) (CD antigen CD83) (O88324)
Organism: Mus musculus (Mouse)
Function: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- T-lymphocyte activation antigen CD86
- Tumor necrosis factor receptor superfamily member 5
- T-lymphocyte activation antigen CD80
- Antigen-presenting glycoprotein CD1d1
- C-C chemokine receptor type 7
- Tumor necrosis factor
- Integrin alpha-X
- B-lymphocyte antigen CD19
- Interleukin-4
- Interleukin-6
Sequence:
MSQGLQLLFLGCACSLAPAMAMREVTVACSETADLPCTAPWDPQLSYAVSWAKVSESGTESVELPESKQNSSFEAPRRRAYSLTIQNTTICSSGTYRCALQELGGQRNLSGTVVLKVTGCPKEATESTFRKYRAEAVLLFSLVVFYLTLIIFTCKFARLQSIFPDISKPGTEQAFLPVTSPSKHLGPVTLPKTETV
Protein: Transcription factor tau 91 kDa subunit (TFIIIC 91 kDa subunit) (Transcription factor C subunit 6) (Q06339)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with TFC3 in DNA binding.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transcription factor tau 131 kDa subunit
- Transcription factor tau 55 kDa subunit
- Transcription factor tau 60 kDa subunit
- Transcription factor tau 138 kDa subunit
- Transcription factor tau 95 kDa subunit
- Transcription factor IIIB 70 kDa subunit
- Transcription factor TFIIIB component B''
- TATA-box-binding protein
- DNA-directed RNA polymerase III subunit RPC1
- DNA-directed RNA polymerase III subunit RPC3
Sequence:
MAVIPAKKRGRPRKSVVAEVPYDSLASPVSENSGSKRPRRNASKKAVANFAQLVHAGRDDVINTTQVNNVDDTDDDDFVLNDEGDGEESDNVEIEFENELESTKNEVADLNSSGSGASVRPSGRRNTVQKLRLKKNSTKNMKSSSPGSSLGQKGRPIRLLKDLSSARDKIERIYGLNKEKLLLLAKVKEGFETSVFDFPFKNIQPDSPYFVCLDPPCKKESAYNKVIGDKNRTVYHEINKTEFENMIKLRTKRLKLLIGEVDAEVSTGDKIEFPVLANGKRRGFIYNVGGLVTDIAWLNIEENTDIGKDIQYLAVAVSQYMDEPLNEHLEMFDKEKHSSCIQIFKMNTSTLHCVKVQTIVHSFGEVWDLKWHEGCHAPHLVGCLSFVSQEGTINFLEIIDNATDVHVFKMCEKPSLTLSLADSLITTFDFLSPTTVVCGFKNGFVAEFDLTDPEVPSFYDQVHDSYILSVSTAYSDFEDTVVSTVAVDGYFYIFNPKDIATTKTTVSRFRGSNLVPVVYCPQIYSYIYSDGASSLRAVPSRAAFAVHPLVSRETTITAIGVSRLHPMVLAGSADGSLIITNAARRLLHGIKNSSATQKSLRLWKWDYSIKDDKYRIDSSYEVYPLTVNDVSKAKIDAHGINITCTKWNETSAGGKCYAFSNSAGLLTLEYLS
Protein: Cytosolic Fe-S cluster assembly factor nbp35 (Nucleotide-binding protein 35) (O94442)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nbp35-cfd1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03038}.
Interaction partners:
- Fe-S cluster assembly protein dre2
- Cytosolic Fe-S cluster assembly factor NAR1 homolog
- NADPH-dependent diflavin oxidoreductase 1
- DNA repair/transcription protein mms19
- Probable cysteine desulfurase, mitochondrial
- Putative 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- Iron-sulfur clusters transporter atm1, mitochondrial
- Iron sulfur cluster assembly protein 1, mitochondrial
- MIP18 family protein C144.16
- Protein isd11
Sequence:
MQIQETVPLDAPEHCPGPSSENAGTASACEGCPNQQICASAPRGEDPDLPLVVERLKEIKHKILVLSGKGGVGKSTFSSQLAWGLSLEEDKQIGLMDVDICGPSIPRIMGVEKEEAHQSSKGWSPIYVCPNLAVMSIGFLLPSEDSSVIWRGPKKNGLIKQFIKDVNWENLDYLIVDTPPGTSDEHLSLVQFFKNSGIDGAVVVTTPQEVALQDVRKEIDFCRKASIPILGLVENMSGFVCPSCKGKSNIFTITTGGGEALAKEMGLPFLGKIPLDPLIARSCDFGKSFIDECPESPASEIIIDIINKIDESLQKRQ
Protein: Gastrin-releasing peptide (GRP) [Cleaved into: Neuromedin-C (GRP-10) (GRP18-27)] (P24393)
Organism: Rattus norvegicus (Rat)
Function: Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake. Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons. Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P07492}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q863C3}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8R1I2}. Note=In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. {ECO:0000250|UniProtKB:Q8R1I2}.
Interaction partners:
- Gastrin-releasing peptide receptor
- Neuromedin B
- Bombesin receptor subtype-3
- Somatostatin
- Pro-glucagon
- Protachykinin-1
- Neurotensin/neuromedin N
- Signal peptidase complex subunit 2
- Neuromedin-B receptor
- Cholecystokinin
Sequence:
MRGSELSLLLLALVLCQAPRGPAAPVSTGAGGGTVLAKMYPRGSHWAVGHLMGKKSTDELPPLYAADRDGLKEQLRGYIRWEEAARNLLGLLEAAGNRSHQPPQDQPLGSLQPTWDPEDGSYFSDAQNAKLVDSLLQVLKGKEGTAS
Protein: 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) (4-hydroxy-2-keto-pentanoic acid aldolase) (4-hydroxy-2-oxopentanoate aldolase) (4-hydroxy-2-oxovalerate aldolase) (HOA) (EC 4.1.3.39) (P9WMK5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in cholesterol degradation. Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxohexanoate (HOHA) to pyruvate and propanal. Can also catalyze the cleavage of 4-hydroxy-2-oxopentanoate (HOPA) to pyruvate and acetaldehyde. The aldehydes produced by this reaction are directly channeled to the dehydrogenase HsaG.
Interaction partners:
- Probable hydratase
- Propanal dehydrogenase
- 3-oxosteroid 1-dehydrogenase
- Oxaloacetate decarboxylase
- Enoyl-CoA hydratase ChsH3
- Flavin-dependent monooxygenase, oxygenase subunit HsaA-triene-9,17-dione 4-hydroxylase, oxygenase subunit)-triene-9,17-dione monooxygenase)
- 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1
- Iron-dependent extradiol dioxygenase
- 3-isopropylmalate dehydrogenase
- 3-isopropylmalate dehydratase large subunit
Sequence:
MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVTH
Protein: Homeobox protein Hox-A4 (Homeobox protein Hox-1.4) (Homeobox protein Hox-1D) (Q00056)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-A3
- Homeobox protein Hox-A5
- Phosphoglycerate mutase 2
- Dynein axonemal light chain 4
Sequence:
MTMSSFLINSNYIEPKFPPFEEYAQHSGSGGADGGPGGGPGYQQPPAPPTQHLPLQQPQLPHAGGGREPTASYYAPRTAREPAYPAAALYPAHGAADTAYPYGYRGGASPGRPPQPEQPPAQAKGPAHGLHASHVLQPQLPPPLQPRAVPPAAPRRCEAAPATPGVPAGGSAPACPLLLADKSPLGLKGKEPVVYPWMKKIHVSAVNPSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNSASASAGPPGKAQTQSPHLHPHPHPSTSTPVPSSI
Protein: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Zgc:158838 protein) (A2VD51)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MASACPPDTGLSAPPGSSGVRKMTITEGPGSSQSMKKTIGHRGVDPTGETTYKKTTSSALKGAIQLGIAHTVGSLSQKAERDVLMQDFYVVESIFFPSEGSNLTPAHHHGDFRFKTYAPIAFRYFRELFGIRPDDYLYSLCNDPLIELPNPGASGSIFYVTSDDEFIIKTVMHKEAEFLQKLLPGYFMNLNQNKRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVPMHLKYDLKGSTYKRRASPKERDKSVPTYKDLDFIQDMPEGIQLEPDNYNALCKTIQRDCLLLQSFKIMDYSLLVGVHNTDLASRERAGVVEGGGSEGTVTPDHRRPQIQKALYSTAMESIQGEAKGKGTLETEDQWGGIPARNSRGERILVYIGIIDILQSYRFIKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKTLKSSPSKKSRSGCSSVVRRLPMGSTASAPGSQTLADARLVYRTHLNQPDLEGESGMPSDRPDLLPQTDPLAGSSSEFAATNVSCSSPGSTRMTSSSPPQRSVGVEVHKSAVTEPDNSTLHSTGAECLDEQLSNEDAISLKDIIPETDICF
Protein: Transcription factor GATA-4 (GATA-binding factor 4) (xGATA-4) (Q91677)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3'. Associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Activates the expression of cardiac MHC-alpha in vivo.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P43694}.
Interaction partners:
Sequence:
MYQSIAMATNHGPSGYEGTGSFMHSATAATSPVYVPTTRVSSMIHSLPYLQTSGSSQQGSPVSGHNMWAQAGVESSAYNPGTSHPPVSPRFTFSSSPPITAPSSREVSYSSPLGISANGREQYSRGLGATYASPYPAYMSPDMGAAWTASPFDSSMLHNLQNRAVTSRHPNIEFFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNLSKSKTLTGQSGSDSLTPSTSSTNSMGEEMRPIKIEPGLSPPYDHSNSISQASALSTITSHGSSYYPMPSLKLSPQNHHSTFNPSPQANSKHDSWNNLVLA
Protein: Endothelin-converting enzyme 1 (EC 3.4.24.71) (A0JMP1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MSTYKRATLEEEELLDTGSDGIYHTSSMQVGVQRGLGLRCWAEKNHSERKLVVLVCALSVALFICIVSLGLHYKESHPGLCLSEPCVSVASAVLGSLDRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEHNMAVMKNLLENTSMKSLSRAEQKAQWYYQACMNESKIEELGAKPLQDLINQTGGWGLKGPWEKDNFQEVLRIVSANFRTSPFFTVFVSTDSKSSNSNIIQVDQSGLGLPSREYYLNKTANEKYLNAYLNFLVELGVLLGGSQDTSQKMMEEIIEFETTLANITVPQVERRDEEKIYYKIQAKELATLAPAIDWMPFLSSVFAPVELNNSEPVVVYAKEYLQKVSELISNTNKSVLNNYMIMKVVRKMVSILDQKFQDAEQRFLEVMYGTKKSCMPRWKLCVSDTDSALGFALGALFVKATFSEDSKAFVEDMVSEIKWAFEDSLKTVSWMDPETKKAAKEKADAIYNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYYNFSARVTADQLRKAPNRDQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSINNEPLNGKHTLGENIADNGGLNAAYKAYVNWIKKNGEEASLPALGMNNHQLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKCELW
Protein: Transmembrane protein 69 (Q5SWH9)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Vasculin-like protein 1
Sequence:
MLRFIQKFSQASSKILKYSFPVGLRTSRTDILSLKMSLQQNFSPCPRPWLSSSFPAYMSKTQCYHTSPCSFKKQQKQALLARPSSTITYLTDSPKPALCVTLAGLIPFVAPPLVMLMTKTYIPILAFTQMAYGASFLSFLGGIRWGFALPEGSPAKPDYLNLASSAAPLFFSWFAFLISERLSEAIVTVIMGMGVAFHLELFLLPHYPNWFKALRIVVTLLATFSFIITLVVKSSFPEKGHKRPGQV
Protein: E3 ubiquitin-protein ligase RHF1A (EC 2.3.2.27) (RING-H2 finger F1a) (RING-H2 zinc finger protein RHF1a) (RING-type E3 ubiquitin transferase RHF1A) (Q4TU14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase involved in the positive regulation of the gametogenesis progression. Mediates the proteasomal degradation of KRP6, a cyclin-dependent kinase inhibitor which accumulates during meiosis and blocks the progression of subsequent mitoses during gametophyte development. Functions in association with RHF2A. Possesses E3 ubiquitin-protein ligase activity when associated with the E2 enzyme UBC8 in vitro.
Interaction partners:
- Cyclin-dependent kinase inhibitor 6
- F-box/LRR-repeat protein 17
- Cyclin-dependent kinase inhibitor 7
- Cyclin family protein
- Homeodomain-like superfamily protein
- Protein AE7-like 2
- Protein AE7-like 1
- Origin of replication complex subunit 6
- E3 ubiquitin-protein ligase APD4
- E3 ubiquitin-protein ligase APD3
Sequence:
MSNFTYTSAFNLSDNSPFNPAIGSSSSSSSALVVASDDDNNTDDACSICLEPFTLQDPSTVTSCKHEYHLQCIIEWSQRSKECPICWQLFVLRDPASQELLAAVEKERLLKTRNISSSSPISIHHSHDDFHSEEEESQFSSFDEQFLRHLTEAAHRRCLLRRRDGQISSSLVSSSDPTTIHPTDLVNLYRLSAISHVEHQNSNPCPSPGSMTPSPVSGHSSIPADSNNGSRISPGPSPSRSSQSPKSPEASSLPEAIKSKLAAASAKYKESISKSKQGLKEKLLARNNSVKELSKGVQREMNAGIAGVARMIERMDFSSKRFGGSAHVSTSTATASGFNFSFKGKRVEANSKSNNNGDKTEPQKLQGGETC
Protein: Probable histone-arginine methyltransferase 1.3 (AtPRMT13) (EC 2.1.1.319) (Coactivator-associated methyltransferase 1A) (Protein arginine N-methyltransferase 4B) (AtPRMT4B) (Q84W92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability (By similarity). Recruited to promoters upon gene activation, methylates histone H3 and activates transcription via chromatin remodeling. Positive regulator in the oxidative stress tolerance that promotes the expression of enzymes preventing oxidative stress such as APX1 and GPX1 by histone methylation (H3R17me2a). Confers tolerance to cadmium CdCl(2) and salt NaCl stresses.
Subcellular location: Nucleus {ECO:0000269|PubMed:27676073}. Cytoplasm {ECO:0000250}.
Interaction partners:
- E3 ubiquitin ligase PARAQUAT TOLERANCE 3
- FRIGIDA-like protein 4a
- Histone H3.1
- Histone H3-like centromeric protein CENH3
- Histone H4
- Histone H3-like 4
- Histone H3-like 3
- Histone H3-like 2
- Histone H3-like 1
- Histone H3-like 5
Sequence:
MEVSSVKKLEQLEYSLESVTDLSSSSVSSSSPAVATFSYVDGVTELRFLQSDSTHCFNFDLASAQLFKLGPVHFICVSDGSSSSEEKSFSKGVNIKFKNEKDSKDFCESFEEWRNDSVVQGSSLQNGTVSANKSKFDNKIEASSAKMYFHYYGQLLHQQNMLQDYVRTGTYYAAVMENHSDFAGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASEMAEYARKLIAGNPLFADRITVIKGKVEDIELPEKADILISEPMGTLLVNERMLESYVIARDRFMTPKGKMFPTVGRIHMAPFSDEFLFIEMANKAMFWQQQNYYGVDLTPLYGSAHQGYFSQPVVDAFDPRLLVASPMFHMIDFTQMKEEDFYEIDIPLKFTASMCTRMHGLACWFDVLFDGSTVQRWLTTAPGAPTTHWYQIRCVLSQPIYVMAGQEITGRLHLIAHSAQSYTIDLTLSAKMWGPGASQGGILQSSTCKFDLKEPYYRMSQPQAYPVAQEPPLQPQPELSTQQDIQTPNDELEEELLQQLPQNPSAQL
Protein: F-box/WD repeat-containing protein 12 (F-box and WD-40 domain-containing protein 12) (F-box only protein 35) (Q6X9E4)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Interaction partners:
- CDK-activating kinase assembly factor MAT1
- S-phase kinase-associated protein 1
- Cyclin-H
- General transcription factor IIH subunit 3
- Transcription initiation factor IIE subunit beta
- General transcription factor IIE subunit 1
- Cullin-1
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MEIRLPDLALKRIFSFLDLFGLLQVSQVNKHWNRIADSDYLWRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSILVMYSLNT
Protein: Secreted frizzled-related protein 2 (sFRP-2) (Q863H1)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
Subcellular location: Secreted.
Interaction partners:
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
Sequence:
MPRGPGSLLLLVLASHCCLGSARGLFFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASSDHLLPATEEAPKVCEACKNKNEDDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKSKTIYKLNGVSERDLKKSVLWLKDSLQCTCEEMNDINAPYLVMGQKLGGELVITSVKRWQKGQREFKRISRSIRKLQC
Protein: Paternally expressed 10 (A0A087WUL4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGPDCPPPPPPPPPNNNNNNNSKHTGHKSACVPNMTERRRDELSEEINNLREKVMKQSEENNNLQSQVQKLTEENTTLREQVEPTPEDEDDDIELRGAAAAAAPPPPIEEECPEDLPEKFDGNPDMLAPFMAQCQIFMEKSTRDFSVDRVRVCFVTSMMTGRAARWASAKLERSHYLMHNYPAFMMEMKHVFEDPQRREVAKRKIRRLRQGMGSVIDYSNAFQMIAQDLDWNEPALIDQYHEGLSDHIQEELSHLEVAKSLSALIGQCIHIERRLARAAAARKPRSPPRALVLPHIASHHQVDPTEPVGGARMRLTQEEKERRRKLNLCLYCGTGGHYADNCPAKASKSSPGKLPGPAVEGPSATGPEIIRSPQDDASSPHLQVMLQIHLPGRHTLFVRAMIDSGASGNFIDHEYVAQNGIPLRIKDWPILVEAIDGRPIASGPVVHETHDLIVDLGDHREVLSFDVTQSPFFPVVLGVRWLSTHDPNITWSTRSIVFDSEYCRYHCRMYSPIPPSLPPPAPQPPLYYPVDGYRVYQPVRYYYVQNVYTPVDEHVYPDHRLVDPHIEMIPGAHSIPSGHVYSLSEPEMAALRDFVARNVKDGLITPTIAPNGAQVLQVKRGWKLQVSYDCRAPNNFTIQNQYPRLSIPNLEDQAHLATYTEFVPQIPGYQTYPTYAAYPTYPVGFAWYPVGRDGQGRSLYVPVMITWNPHWYRQPPVPQYPPPQPPPPPPPPPPPPSYSTL
Protein: PII-like nitrogen regulatory protein (Q9ZA65)
Organism: Klebsiella pneumoniae
Interaction partners:
Sequence:
MKLVTVVIKPFKLEDVRERLSSMGIQGLTVTEVKGFGRQKGHAELYRGAEYSVNFLPKVKIDVAIADDQLDEVVDVISKAAYTGKIGDGKIFVAELQRVIRIRTGESDEAAL
Protein: Tom20p (Q5AIA0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004572}.
Interaction partners:
- Protein channel
- Tom22p
- Translocase of outer membrane 40 kDa subunit
- Tom7p
- Mitochondrial outer membrane protein porin
- Mitochondrial Rho GTPase 1
- SAM complex subunit
- SAM complex subunit
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM17
Sequence:
MNKGLTITAIAAAAIAGYAVYFDYQRRNSADFRKSLKKREVKQKKLKAKKEAESKQNKLEAVKKALLEDLAQNPIPTDLTEREAFFMEQVAVGEQKAKVDAIEAAICFYKALAVYPNPTDILGIYQKTVPEEVYELVVMMIAVYPPASVSSILNKGAPTVKDLKPTEEDLD