wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase PP2A-5 catalytic subunit (EC 3.1.3.16) (Protein phosphatase 2A isoform 5) (O04951)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Associates with the serine/threonine-protein phosphatase PP2A regulatory subunits A and B' to positively regulates beta-oxidation of fatty acids and protoauxins in peroxisomes by dephosphorylating peroxisomal beta-oxidation-related proteins. Involved in the positive regulation of salt stress responses. May function by increasing chloride channel activities on vacuolar membranes.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:25489022}. Peroxisome {ECO:0000269|PubMed:25489022}. Note=Interacts with B'THETA in the cytosol and peroxisomal import occurs by a piggybacking transport. {ECO:0000269|PubMed:25489022}.
Interaction partners:
- PP2A regulatory subunit TAP46
- Serine/threonine-protein phosphatase 2A activator
- Protein phosphatase methylesterase 1
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Leucine carboxyl methyltransferase 1 homolog
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Anaphase-promoting complex subunit 1
Sequence:
MPPATGDIDRQIEQLMECKALSETEVKMLCEHAKTILVEEYNVQPVKCPVTVCGDIHGQFYDLIELFRIGGSSPDTNYLFMGDYVDRGYYSVETVSLLVALKVRYRDRLTILRGNHESRQITQVYGFYDECLRKYGNANVWKHFTDLFDYLPLTALIESQVFCLHGGLSPSLDTLDNIRSLDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDIATQFNHTNGLSLISRAHQLVMEGFNWCQEKNVVTVFSAPNYCYRCGNMAAILEIGENMDQNFLQFDPAPRQVEPETTRKTPDYFL
Protein: 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.159, EC 1.1.1.178, EC 1.1.1.201, EC 1.1.1.239, EC 1.1.1.35, EC 1.1.1.36, EC 1.1.1.62, EC 1.1.1.63) (E3TDR7)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Interaction partners:
- Enoyl-CoA hydratase, mitochondrial
- tRNA methyltransferase 10 homolog C
- Mitochondrial ribonuclease P catalytic subunit
- 3-ketoacyl-CoA thiolase, mitochondrial isoform X1
- Trifunctional enzyme subunit beta, mitochondrial
- 3-ketoacyl-CoA thiolase, peroxisomal
- Peroxisomal bifunctional enzyme
- Trifunctional enzyme subunit alpha, mitochondrial
- Trifunctional enzyme subunit alpha, mitochondrial
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Sequence:
MANIRKLKGMVGLVTGGASGLGRATVERLVNHGASAVILDLPSSDGHNVAAALGERCAFAPADVTSESDVRSAVDLAKEKFGRLDLAVNCAGIAVAVKTYNFKKDIPHSLEDFSRVINVNIAGSFNVIRLAAGMMGKNEPDADGHRGCIVNTASVAAFDGQVGQAAYSASKGGIVGMTLPIARDLAPMGIRVVTIAPGLFSTPLLAGLPEKVQSFLARQVPFPSRLGDPAEFAHLVTAIAENPMINGEVIRLDGAIRMQP
Protein: E3 ubiquitin-protein ligase KEG (EC 2.3.2.27) (EC 2.7.11.1) (Protein KEEP ON GOING) (RING finger protein KEG) (RING-type E3 ubiquitin transferase KEG) (Q9FY48)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates E2-dependent protein ubiquitination. Acts as a negative regulator of abscisic acid signaling. Required for ABI5 degradation, by mediating its ubiquitination. Together with EDR1, may regulate endocytic trafficking and/or the formation of signaling complexes on trans-Golgi network (TGN)/ early endosome (EE) vesicles during stress responses.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:21343429}. Early endosome {ECO:0000269|PubMed:21343429}.
Interaction partners:
- Protein ABSCISIC ACID-INSENSITIVE 5
- Ubiquitin-ribosomal protein eS31y fusion protein
- Ubiquitin-ribosomal protein eS31z fusion protein
- Ubiquitin-ribosomal protein eS31x fusion protein
- Ubiquitin-ribosomal protein eL40z fusion protein
- Ubiquitin-ribosomal protein eL40y fusion protein
- Protein TIME FOR COFFEE
- TIC-like protein
- Protein TIFY 3B
- Histone-lysine N-methyltransferase SUVR5
Sequence:
MVGRVKVPCCSVCHTRYNEDERVPLLLQCGHGFCKDCLSKMFSTSSDTTLTCPRCRHVSVVGNSVQGLRKNYAMLALIHAASGGANFDCDYTDDEDDDDEEDGSDEDGARAARGFHASSSINSLCGPVIEVGAHPEMKLVRQIGEESSSGGFGGVEMWDATVAGGGGRCKHRVAVKKMTLTEDMDVEWMQGQLESLRRASMWCRNVCTFHGVVKMDGSLCLLMDRCFGSVQSEMQRNEGRLTLEQILRYGADVARGVAELHAAGVICMNIKPSNLLLDASGNAVVSDYGLAPILKKPTCQKTRPEFDSSKVTLYTDCVTLSPHYTAPEAWGPVKKLFWEDASGVSPESDAWSFGCTLVEMCTGSTPWDGLSREEIFQAVVKARKVPPQYERIVGVGIPRELWKMIGECLQFKPSKRPTFNAMLATFLRHLQEIPRSPSASPDNGIAKICEVNIVQAPRATNIGVFQDNPNNLHRVVLEGDFEGVRNILAKAAAGGGGSSVRSLLEAQNADGQSALHLACRRGSAELVEAILEYGEANVDIVDKDGDPPLVFALAAGSPQCVHVLIKKGANVRSRLREGSGPSVAHVCSYHGQPDCMRELLVAGADPNAVDDEGETVLHRAVAKKYTDCAIVILENGGSRSMTVSNAKCLTPLHMCVATWNVAVIKRWVEVSSPEEISQAINIPSPVGTALCMAASIRKDHEKEGRELVQILLAAGADPTAQDAQHGRTALHTAAMANNVELVRVILDAGVNANIRNVHNTIPLHMALARGANSCVSLLLESGSDCNIQDDEGDNAFHIAADAAKMIRENLDWLIVMLRSPDAAVDVRNHSGKTVRDFLEALPREWISEDLMEALLKRGVHLSPTIYEVGDWVKFKRGITTPLHGWQGAKPKSVGFVQTILEKEDMIIAFCSGEARVLANEVVKLIPLDRGQHVRLRADVKEPRFGWRGQSRDSVGTVLCVDEDGILRVGFPGASRGWKADPAEMERVEEFKVGDWVRIRQNLTSAKHGFGSVVPGSMGIVYCVRPDSSLLVELSYLPNPWHCEPEEVEPVAPFRIGDRVCVKRSVAEPRYAWGGETHHSVGKISEIENDGLLIIEIPNRPIPWQADPSDMEKIDDFKVGDWVRVKASVSSPKYGWEDITRNSIGVMHSLDEDGDVGIAFCFRSKPFSCSVTDVEKVTPFHVGQEIHMTPSITQPRLGWSNETPATIGKVMRIDMDGTLSAQVTGRQTLWRVSPGDAELLSGFEVGDWVRSKPSLGNRPSYDWSNVGRESIAVVHSIQETGYLELACCFRKGRWSTHYTDLEKIPALKVGQFVHFQKGITEPRWGWRAAKPDSRGIITTVHADGEVRVAFFGLPGLWRGDPADLEVEPMFEVGEWVRLREGVSCWKSVGPGSVGVVHGVGYEGDEWDGTTSVSFCGEQERWAGPTSHLEKAKKLVVGQKTRVKLAVKQPRFGWSGHSHGSVGTISAIDADGKLRIYTPAGSKTWMLDPSEVETIEEEELKIGDWVRVKASITTPTYQWGEVNPSSTGVVHRMEDGDLCVSFCFLDRLWLCKAGELERIRPFRIGDRVKIKDGLVTPRWGWGMETHASKGHVVGVDANGKLRIKFLWREGRPWIGDPADIVLDETSG
Protein: Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (InsP6K2) (EC 2.7.4.-) (P(i)-uptake stimulator) (PiUS) (Q9UHH9)
Organism: Homo sapiens (Human)
Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).
Subcellular location: Nucleus {ECO:0000269|PubMed:11502751}.
Interaction partners:
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
- Inositol-pentakisphosphate 2-kinase
- Inositol hexakisphosphate kinase 1
- Inositol hexakisphosphate kinase 3
- DNA-directed RNA polymerase I subunit RPA43
- Dual specificity protein phosphatase 16
Sequence:
MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRKFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVDNSDCEPKSKLLRWTTNKKHHVLETEKTPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYTVEKKGNISSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKERPEVVLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDTVVHEGQDAGYIFGLQSLIDIVTEISEESGE
Protein: Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1) (Q9BU89)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity).
Interaction partners:
- Deoxyhypusine synthase
- Eukaryotic translation initiation factor 5A-1
- Eukaryotic translation initiation factor 5A-2
- Eukaryotic translation initiation factor 5A-1-like
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
- Fumarate hydratase, mitochondrial
- Bifunctional purine biosynthesis protein ATIC
- Adenylosuccinate synthetase isozyme 2
- Adenylosuccinate synthetase isozyme 1
Sequence:
MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGAPS
Protein: G-protein coupled receptor 146 (Q99LE2)
Organism: Mus musculus (Mouse)
Function: Orphan receptor.
Subcellular location: Cell membrane {ECO:0000305|PubMed:38503280}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MWSCGPLNSTAWAEEPLCRNLRLGLWVLSLLYLGAGVPVSLGYNALLVLANLASKNTMTMPDVYFVNMAVAGLVLTALAPAYLLGPAHSRWALWSLSSEAHVTLLILFNVASLVTMYSTALLSLDYYIERALPRTYMASVYNTRHVCGFVWGGAVLTSFSSLLFYICSHVSSRIAECARMQNTEAADAILVLIGYVVPGLAVLYALALISRIGKEDTPLDQDTSRLDPSVHRLLVATVCTQFGLWTPYYLSLGHTVLTSRGRTVEGHYLGILQVAKDLAKFLAFSSSSVTPLLYRYINKAFPGKLRRLMKKMHCGRRHCSPDPSGIQQVMAQA
Protein: Plasma membrane calcium-transporting ATPase mca-1 (EC 7.2.2.10) (Membrane calcium ATPase-1) (G5EFR6)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P23634}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361146}.
Interaction partners:
- Calcium-transporting ATPase
- Calcium-transporting ATPase
- Amidophosphoribosyltransferase
- Calcium-transporting ATPase
- Calcium-transporting ATPase
Sequence:
MQKSQNVTAVTETNGVAAALGGHHTSPDTNAGKTKDAKEFGCSLGDLRGLMEARGAEAIVRLSTEHEGVEGLCKKLKTDSLVGLNGEQADLDRRRHVYGANTIPPAKSKGFVRLVLDACKDPTLVILVLSGFINLALSFYEPTSAAEDATQHLVNATTAAILANGTFMSTTEAPSEGHGTAWIEGVAILLCVIVVVLVTAVNDYSKERQFRSLQEKIETGQKFSVIRNGEAIDVPVSDLVVGDIARVKYGDLLPADGFLIQSNDLKIDESSLTGESDHIKKSIESDPVLLSGTYAMEGSGKMLITAVGVNSQTGIIMTLLGAGKAGIGDDDSTSTSSSSSSSSSSSGSSSNGSSDSSKSGDDDLTAKSVLQAKLSKLALQIIYCGTTIAIIALIVLVTRFCLDHYVFEKNEFSLVDIQMFVKFFIIAVTILVISIPEGLPLAIALALTYSVRKMMHDNNLVRHLDACETMGNATSICSDKTGTLTTNRMTVVQSYINGNHYTSQEAQPHGANLPGSTGPILMEAISVNCAYNSMIVEPTKAGEQIQQLGNKTECGLLGFVNRLGGDYAAIRKKFPEHDLTKVYTFNSSRKCMMTVVPYAENGQNIGYRVYCKGASEIVLGRCTYLIGSDGKPHQLTGDRLKEITSTIIHEMANSGLRTICVAYKTIIKKGTRDVEKTEIEFAEDSDIDWDDEDAMYQNFTGIAICGIQDPVRPEVPVAISKCKKAGITVRMVTGDNIMTARAIAMSCKILEPGEDFLALEGKEFNERIRDENGKVSQAKLDEIWPRLRVLARAQPADKYTLVKGIIDSKATPQREIVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVITAFVGAVTVSDSPLKAVHMLWINLIMDTLASLALATEQPTDELLERKPYGRKKSLISRTMVKNILCHALYQLIIIFVIFFYGDTIFGIKTGLYAPLFAPPSQHFTLVFNAFVMMTVFNEINARKVHGERNVFKGLASNRVFCVIWVTTFIAQIIIVQFGGAWFSTAPLTLQQWIVCLVLGFSTLIWGQIVATIPSKKLPKAWKVGKGEVQPANLHINGDYNVRARSRAVTLRRSGKSLWVRGMFIIGNHLRVLRAFGMEKSEKAAFGRTAPAMTAEAAERWRASYRKYRHQKHQEKKATAETAESVKSADWAKEQKEKKKTFKQIKQVARGKSLDKDSKKHHKKRKDQTNVDMEDIELN
Protein: GDSL-like Lipase/Acylhydrolase superfamily protein (F4I0R0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MLVLALFSIYFLSIEAVRNESFPALLAFGDSMVDTGNNNYLLTLMKGNYWPYGWNFDSKIPTGRFGNGRVFSDVVGIILKSSLQCFFVISAEGLGIKRIVPAYRKLYIAPSDLKTGVSFASGGAGVDPVTSKLLRVLSPADQVKDFKGYKRKLKGVVGRSKAKKIVANSVILVSEGNNDIGITYAIHDAGMRLMTPKVYTSKLVGWNKKFIKDLYDHGARKFAVMGVIPLGCLPMSRLIFGGFFVWCNFLANTISEDYNKKLKSGIKSWRGASDFRGARFVYVDMYNSLMDVINNHRKYGFTHEKNGCCCMLTAIVPCSNPDKYVFYDFAHPSEKAYKTIAKKLVEDIKTGLA
Protein: Transducin/WD40 repeat-like superfamily protein (WD repeat protein-like) (Q8RXD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Flowering time control protein FY
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Cleavage and polyadenylation specificity factor subunit 2
- Protein TRAUCO
- 30-kDa cleavage and polyadenylation specificity factor 30
- Cleavage and polyadenylation specificity factor subunit 3-I
- Protein RBL
- Cleavage stimulating factor 64
- Zinc finger CCCH domain-containing protein 65
- Ribonuclease J
Sequence:
MVEFTEREDRVSLELSEEIIQSMEPGAVFRDYNCRISSIDFHKTSTCMVTASDDDSIRLYDVASATCLKTINSKKYGVDLVCFTSHPTTVIYSSRNGWDDSLRLLSLHDNKYLRYFKGHHDRVVSLSLCSGGECFISGSLDRTVLLWDQRVEKCQGLLRVQGRPAAAYDDQGLIFAIAFGGYIRMFDARMYEKGPFEIFSVGGDLSEANVVKFSNDGRLMLLTTMDGFIHVLDSFRGTLLSTFSVKPVAGESTLDAAFSPEGMFVVSGSGDGSTHAWGVRSGKQVHSWMGLGSEPPVIKWGPGSPMFVTGSSELAFVIPDLSKLPAYAIRK
Protein: LD42595p (Pasiflora 2, isoform A) (Pasiflora 2, isoform B) (Pasiflora 2, isoform C) (Q9VHF5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Pasiflora 1, isoform A
- Kune-kune
- UPAR/Ly6 domain-containing protein cold
- Transferrin 2
Sequence:
MMNYGRKTPSTYRSNPSVYSHATGRSSTNLHSKMSRSTRSVRIPWYQRPLLKNNQYIDIQKGAMLVGLFAIFLSLFTIATSIFDIYCYAMAAPGSTHYGYYIISYEFVYVGNKHVRNMLIVFALFSLIMALINFVTSVLLCVALRKEYERKVMPWLWSFAIFTVWRALALIFFAIVNDLYFAYNVIMVLLWTIFCVLSIYGWAVVYSLFLELVDLTKLEDLAHLRMGTMASLHASTANSLAGSRPTTPHSTVSTMPVG
Protein: F-box protein At3g44326 (Q2V3R1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Nodulin-like / Major Facilitator Superfamily protein
Sequence:
MLSSSSSSTVEQPSRGGSPGINAVSSDVLRSNILTRLDGSSLAALSCTCSNLNSFCSDESLWRQQCSATWPSTSDTRVQSIISTFPDGHRTFFSDSFPFLEHDVGINLPPSVDTSELISAVDIFYKDDVIFSRVHVTETVSGWFLCSPMRVDLVEPKELIPTRVLVTDQCKDDTWKSDLEENLSLSWILIDPTCKRAADVSTRKPVSVHRHWLTGEVHVKFSSIFVVGNKKRSEQVEFTVTVVLAVFNRREEETAVMQIREVSLVAEDKDGRNLGGKVSLEILVAAMGMKRRFRAGGEEEGKEKYIEYMERKTAKAEMKWRRGKETAMETAACWIAVLLLGFLLCFYLFMHKNLVAIMKKLIK
Protein: Sigma factor regulator, VreR (Transmembrane sensor) (O69006)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
Sequence:
MTASDSAADETGDLRHEAHAWVISLTSGRVTQGDARAFRQWCARSPQHLRAFVEARDLWQALGSAAALPLEPPAVAQIAPRRFGRRWFVGGALAASVALFVLRPSLLDHGLGGADYVTAVGEQRQVQVSGETRIEMNTRTRLNVRRNQEQQETIELLGGEAEIIASHPPQSSLRVMAGSAWLSASRARFNVRSSGDVCVVTCLEGSVRLEHLGQRLDLQAGQQLTFDERRNGPPVPFDVAEVMAWRERMLVFNDVPLATVIDEINRYRPGMLLLLDKALGRRRVQARFSLDQLADVATLIRDAYGIEVTRLPGGVVLLG
Protein: THO complex subunit tho7 (Q9P7J4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- THO complex subunit tho5
- Uncharacterized protein P25A2.03
- THO complex subunit Tho3
- ATP-dependent RNA helicase uap56
- Pre-mRNA-splicing factor cwf28
- THO complex subunit 2
- mRNA export protein mlo3
- Uncharacterized RNA-binding protein C106.12c
- PCI domain-containing protein C1105.07c
- SAGA complex subunit Sus1
Sequence:
MEETAIRSRLTVEERPLKRLISRCLGFAAQNVDEANLRDLEIEFSALSAFWLRLQMQLDMNAKEVDVYEGELKKTQTFCEAEKTEISQLEQDLLVAQEELRKREQYDELAKPIMSKGLRSRTEQQESIGKLQDAIRELEEENANYVKAWNLRKDIFDETLKQMNHLQSILHPPSNPESDSEEGIASEGENPSSSSSTQYKAK
Protein: Calcium-dependent protein kinase 6 (EC 2.7.11.1) (Calcium-dependent protein kinase isoform CDPK3) (AtCDPK3) (Calmodulin-domain protein kinase CDPK isoform 6) (Q38872)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger. Functions in abscisic acid (ABA) regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure. Phosphorylates FD.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19029837}; Lipid-anchor {ECO:0000269|PubMed:19029837}. Nucleus {ECO:0000269|PubMed:25661797}.
Interaction partners:
- Guard cell S-type anion channel SLAC1
- Respiratory burst oxidase homolog protein D
- Respiratory burst oxidase homolog protein F
- Respiratory burst oxidase homolog protein B
- Calcium-binding protein CP1
- S-type anion channel SLAH3
- LRR receptor-like serine/threonine-protein kinase GHR1
- Protein phosphatase 2C 56
- Aluminum-activated malate transporter 12
- Oxysterol-binding protein-related protein 2A
Sequence:
MGNSCRGSFKDKIYEGNHSRPEENSKSTTTTVSSVHSPTTDQDFSKQNTNPALVIPVKEPIMRRNVDNQSYYVLGHKTPNIRDLYTLSRKLGQGQFGTTYLCTDIATGVDYACKSISKRKLISKEDVEDVRREIQIMHHLAGHKNIVTIKGAYEDPLYVHIVMELCAGGELFDRIIHRGHYSERKAAELTKIIVGVVEACHSLGVMHRDLKPENFLLVNKDDDFSLKAIDFGLSVFFKPGQIFKDVVGSPYYVAPEVLLKHYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGYIDFDTDPWPVISDSAKDLIRKMLCSSPSERLTAHEVLRHPWICENGVAPDRALDPAVLSRLKQFSAMNKLKKMALKVIAESLSEEEIAGLRAMFEAMDTDNSGAITFDELKAGLRRYGSTLKDTEIRDLMEAADVDNSGTIDYSEFIAATIHLNKLEREEHLVSAFQYFDKDGSGYITIDELQQSCIEHGMTDVFLEDIIKEVDQDNDGRIDYEEFVAMMQKGNAGVGRRTMKNSLNISMRDV
Protein: Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST 13-13) (GST class-kappa) (GSTK1-1) (hGSTK1) (Glutathione S-transferase subunit 13) (Q9Y2Q3)
Organism: Homo sapiens (Human)
Function: Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds. Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).
Subcellular location: Peroxisome {ECO:0000269|PubMed:14742434}.
Interaction partners:
- Hematopoietic prostaglandin D synthase
- Peroxisomal targeting signal 1 receptor
- Glutathione S-transferase omega-2
- Glutathione S-transferase P
- Glutathione S-transferase theta-2B
- Glutathione S-transferase omega-1
Sequence:
MGPLPRTVELFYDVLSPYSWLGFEILCRYQNIWNINLQLRPSLITGIMKDSGNKPPGLLPRKGLYMANDLKLLRHHLQIPIHFPKDFLSVMLEKGSLSAMRFLTAVNLEHPEMLEKASRELWMRVWSRNEDITEPQSILAAAEKAGMSAEQAQGLLEKIATPKVKNQLKETTEAACRYGAFGLPITVAHVDGQTHMLFGSDRMELLAHLLGEKWMGPIPPAVNARL
Protein: Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) (Q14103)
Organism: Homo sapiens (Human)
Function: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.
Subcellular location: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein A3
- Eukaryotic translation initiation factor 4 gamma 1
- Heat shock cognate 71 kDa protein
- Heterogeneous nuclear ribonucleoprotein Q
- Polyadenylate-binding protein-interacting protein 1
- Heterogeneous nuclear ribonucleoprotein U
- Nucleolin
- ELAV-like protein 1
- DNA
- Transportin-1
Sequence:
MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGSAESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQNSYKPY
Protein: Tumor necrosis factor ligand superfamily member 18 (A9Y5K7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSLSAEHCRDTSGDRGGGGGFNGALIHQRTLIRGLIIWVTLLTLGLAASISLHFIPKESPAPSKQQGSETTSNNVYPGKKIDLMTFTPNWENTDVELLQWNTVEERFIKGEGQLTVTQGGAYFLYLQVTLDSRKKENHTITVQTQKQNVILKGYINGSNLSSGFLATGIYLDDDDTFNVTCKPKAKIQNSHIETYMGVIKLG
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q9VZI9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MNWAIYLLLALISLGRATPVPNRQYSCMSYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRRTCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSICSQSECTSSAPTSKTSSLYYCCCSGGVCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAVQYCRTAKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPTAEQGINIIATTTTAAAVHHQMSSDTTGLIQPPPNQQIPLAALEREKNHLSYPQQQLQPYQGRNPCQERNLAPLTMRTPPVLVERSKKHSFQTQPQENSLSCLEHDVSVEELIASHQHQQQKNTIVSTGGNGNSCLGQGFPKQQNTDQKLRGWHGVRALIHKKLFRKEHAEELCRQLQLGEEKSNLVTALRRPNNLDLNPRLDKPPPDQLRSAEQRMGTPAHIVPRSLSSSLIKHINGTTNNNSIQSHGSELQTLTRPASKRRPGHLRTNSLMATTGQGPPTEQQMRRQHSLEVFREVFSGRGSSERLRDPSERVKTPGDVPPSVRKARASKTLSLYDDRMMDSSLLNIL
Protein: Chorion protein c at 7F (IP19624p) (Q9W3E7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Chorion protein S36
- Chorion protein b at 7F, isoform A
- Chorion protein S38
- Chorion protein a at 7F, isoform A
- Uncharacterized protein
- Chorion protein S19
- RE05851p
- Vitelline membrane protein Vm32E
- Uncharacterized protein
- Follicle cell protein 3C-1
Sequence:
MAADGSWPILLLLVSTQAIIHAENLSESTPGPDEEYNVSTTPGAPLEETTNRLAARVEPYDKGDREQYDVIDVATATGTVMGKPRSGQTTRIYTTGEVDESFWLKHLGDDFKHAIHLQVGGTNEEYNRLINRTQNGVHEEVHHEYLPGAERPGSAVQPPSPLPAPHQSRPAYRQGFDNRAMAMKQQYLIHQQTQQSHPAQQRYNYAQQHAQHYAPQPQLQPQPQPQPQYPQHTPHRNTYAMPQNYGQQNYKPQSYIINSSEDQLHAEQSNPSPMKSAGEDRQHHEEEFDSFGGQLNFKSPFNDYGSRPARDLTYLLYKRGL
Protein: Polynucleotide kinase 3'-phosphatase (A0A0G2JUH4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA repair protein XRCC1
- DNA polymerase beta
- Tyrosyl-DNA phosphodiesterase 1
- Endonuclease 8-like 2 lyase Neil2)
- Transcription termination factor 2
- Nei endonuclease VIII-like 1
- Aprataxin and PNK-like factor
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- Non-homologous end-joining factor 1
- Endonuclease III-like protein 1 lyase)
Sequence:
MSELGSRGRLWLQSPTGGPPPIFLPSDGQALVLGRGPLTQVMDRKCSRNQVELIADPETRTVAVKQLGVNPSTVGVQELKPGVSGSLSVGDVLYLVNGLYPLTLRWEEISTPGSPPDTPPGNPVDPEEGKDTEPQKKRMRKSSPGWESFKQLLVFTASGVKPRGKVAAFDLDGTLITTRSGKVFPTSPSDWRILYPEIPKKLQELAAEGYKLVILTNQMGIGRGKLPAEVFKAKVEAVLEKLGVPFQVLVATHAGLNRKPVSGMWDHLQEKGNEGIPISIGDSVFVGGKRAPSQLGPREEEKGFLLCRPPGKPGFALNVGLPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSFLLSPNPEVVVAVGFPGAGKSTFIQKHLVSAGYVHVNRDTLGSWQRCVNSCQAALRQGKQVVIDNTNPDIQSRARYIQCAKDAGVPCRCFSFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEGFLEILQVPFRLQEHLDPALQRLYCQFSEG