wanglab/gogpt-training-data huggingface dataset:
Protein: Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) (Q5T2W1)
Organism: Homo sapiens (Human)
Function: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9JJ40}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ40}. Cell membrane {ECO:0000250|UniProtKB:Q9JIL4}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes. {ECO:0000250|UniProtKB:Q9JJ40}.
Interaction partners:
- Cystic fibrosis transmembrane conductance regulator
- PDZK1-interacting protein 1
- Sodium/hydrogen exchanger 3
- A-kinase anchor protein 10, mitochondrial
- Scavenger receptor class B member 1
- Solute carrier family 22 member 12
- Chloride anion exchanger
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- Sodium-dependent phosphate transport protein 1
- Solute carrier family 2, facilitated glucose transporter member 9
Sequence:
MTSTFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTEM
Protein: Uncharacterized protein (P96911)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MAGDRGADPGPANVTPGADDHAQHASPTVLCPQGHVNAWDYRFCERCGSPIGVVPWPSEESGTRQTAPARSFVPLVVLAATLLVVAVVVTAVGYAVTRPARNDREEPSSARGAATTGVPFAQAEAASCPDDPVLEAESIDLTSDGLAVSAAFMSACAGGDVESNSALEVTVADGRRDVAAGSFDFSADPLRIEPGVPARRTLVFPPGMYWRTPDMLSGAPALAATRKGRSDRSAARGGSARTTMVAAASAAPAYGSINAVAGAVLVELRDSDFPYVRVGIANRWVPQVSSKRVGLVAAGKTWTSADILRDHLALRQRFGGARLVWSGHWTTFSGPDFWVTVVGPAQPTAAEANR
Protein: Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1) (Q9JME2)
Organism: Mus musculus (Mouse)
Function: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Carbohydrate sulfotransferase 12
- Carbohydrate sulfotransferase
- Carbohydrate sulfotransferase 15
- Carbohydrate sulfotransferase 3
- Chondroitin sulfate N-acetylgalactosaminyltransferase 2
- Chondroitin sulfate N-acetylgalactosaminyltransferase 1
- Carbohydrate sulfotransferase 7
Sequence:
MKPALLEVMRMNRICRMVLATCFGSFILVIFYFQSMLHPVMRRNPFGVDICCRKGSRSPLQELYNPIQLELSNTAILHQMRRDQVTDTCRANSAMSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLSGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYNTSFHKRYGTKIIRRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVSGYLKFPTYAKSTRTTDEMTTEFFQNISAEHQTQLYEVYKLDFLMFNYSVPNYLKLD
Protein: Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (Solute carrier family 35 member B3) (Q922Q5)
Organism: Mus musculus (Mouse)
Function: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9H1N7}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- GDP-fucose transporter 1
- Solute carrier family 35 member C2
Sequence:
MDLKFNNSRKYVSISVPSKTQAMSPHIKSVEDVVVLGVNLSKFSKLTQFLICVAGVFVFYLIYGYLQELIFSVEGFKPYGWYLTLVQFAFYSVFGLIELQLTQDRRRRIPGKTYMLIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNLADVSAAVCMSLGLIWFTLADSTIAPNFNLTGVMLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLSCTSGLGPAVAFCSKNPVGTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTVVLSFLFFAKPFTFQYIWSGLLVVLGIFLNVYSKNMDKIRLPSVYNMIKKAMDMKKSRTLAQTV
Protein: DNA repair protein UVH3 (EC 3.1.-.-) (ERCC5 homolog) (RAD2 homolog) (AtRAD2) (AtUVH3) (AtXPG) (UV hypersensitive protein 3) (XPG homolog) (Q9ATY5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative single-stranded DNA endonuclease involved in nucleotide excision repair (NER) of UV- and oxidative damaged DNA. May make the 3'-incision step in NER. Seems to play a role in senescence program.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- General transcription and DNA repair factor IIH helicase subunit XPD
- DNA repair endonuclease UVH1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB1
- Crossover junction endonuclease MUS81
- General transcription factor IIH subunit 2
- DNA excision repair protein ERCC-1
- General transcription and DNA repair factor IIH subunit TFB1-1
- General transcription and DNA repair factor IIH subunit TFB1-3
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB2
- Protein CHROMATIN REMODELING 8
Sequence:
MGVQGLWELLAPVGRRVSVETLANKRLAIDASIWMVQFIKAMRDEKGDMVQNAHLIGFFRRICKLLFLRTKPIFVFDGATPALKRRTVIARRRQRENAQTKIRKTAEKLLLNRLKDIRLKEQAKDIKNQRLKQDDSDRVKKRVSSDSVEDNLRVPVEEDDVGASFFQEEKLDEVSQASLVGETGVDDVVKESVKDDPKGKGVLLDGDDLDNLVQDSSVQGKDYQEKLDEMLAASLAAEEERNFTSKASTSAAAIPSEEDEEEDSDGDEEILLPVMDGNIDPAVLASLPPSMQLDLLAQMREKLMAENRQKYQKVKKAPEKFSELQIEAYLKTVAFRREINEVQRSAGGRAVGGVQTSRIASEANREFIFSSSFAGDKEVLASAREGRNDENQKKTSQQSLPVSVKNASPLKKSDATIELDRDEPKNPDENIEVYIDERGRFRIRNRHMGIQMTRDIQRNLHLMKEKERTASGSMAKNDETFSAWENFPTEDQFLEKSPVEKDVVDLEIQNDDSMLHPPSSIEISFDHDGGGKDLNDEDDMFLQLAAGGPVTISSTENDPKEDTSPWASDSDWEEVPVEQNTSVSKLEANLSNQHIPKDISIAEGVAWEEYSCKNANNSVENDTVTKITKGYLEEEADLQEAIKKSLLELHDKESGDVLEENQSVRVNLVVDKPSEDSLCSRETVGEAEEERFLDEITILKTSGAISEQSNTSVAGNADGQKGITKQFGTHPSSGSNNVSHAVSNKLSKVKSVISPEKALNVASQNRMLSTMAKQHNEEGSESFGGESVKVSAMPIADEEITGFLDEKDNADGESSIMMDDKRDYSRRKIQSLVTESRDPSRNVVRSRIGILHDTDSQNERREENNSNEHTFNIDSSTDFEEKGVPVEFSEANIEEEIRVLDQEFVSLGDEQRKLERNAESVSSEMFAECQELLQIFGIPYIIAPMEAEAQCAFMEQSNLVDGIVTDDSDVFLFGARSVYKNIFDDRKYVETYFMKDIEKELGLSRDKIIRMAMLLGSDYTEGISGIGIVNAIEVVTAFPEEDGLQKFREWVESPDPTILGKTDAKTGSKVKKRGSASVDNKGIISGASTDDTEEIKQIFMDQHRKVSKNWHIPLTFPSEAVISAYLNPQVDLSTEKFSWGKPDLSVLRKLCWEKFNWNGKKTDELLLPVLKEYEKRETQLRIEAFYSFNERFAKIRSKRINKAVKGIGGGLSSDVADHTLQEGPRKRNKKKVAPHETEDNNTSDKDSPIANEKVKNKRKRLEKPSSSRGRGRAQKRGRGRGRVQKDLLELSDGSSDDDDDDDKVVELEAKPANLQKSTRSRNPVMYSAKEDDELDESRSNEGSPSENFEEVDEGRIGNDDSVDASINDCPSEDYIQTGGGFCADEADEIGDAHLEDKATDDYRVIGGGFCVDEDETAEENTMDDDAEILKMESEEQRKKGKRRNEEDASLDENVDIHFGNSSAGGLSAMPFLKRKKRKN
Protein: EG:114D9.2 protein (Q9W5A4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGCNGAVSPPPAPPMLKAIPPPPPPMAPSMMPPPPPPCPGAPPPPPSMAQTMAPAPPKVDLPKKNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGMIHCPFAKHSITQTTSIPPGNYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREESGRERERTVRRQ
Protein: Kinesin-like protein KIN-13A (AtKINESIN-13A) (AtKIN13A) (Q940B8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Internal motor kinesin involved in trichome morphogenesis. Participates in regulating the formation of Golgi-associated vesicles. Plays a central role in microtubule disassembly via the active ARAC10-ICR5 cascade, which establishes the secondary cell wall pattern in metaxylem vessel cells. Acts redundantly with KIN13B to modulate cell wall synthesis and cell expansion via the THE1 pathway.
Subcellular location: Golgi apparatus, Golgi stack {ECO:0000269|PubMed:15574882, ECO:0000269|PubMed:19939242}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20832900, ECO:0000269|PubMed:24280391}. Note=Localized to cortical microtubules in secondary wall pits when associated with ICR5. The N-terminal region of the protein is required for its localization at microtubules, but the truncated protein can be recruited to microtubules upon interaction with ICR5. {ECO:0000269|PubMed:20832900, ECO:0000269|PubMed:24280391}.
Interaction partners:
- Interactor of constitutive active ROPs 5
- Rac-like GTP-binding protein ARAC10
- Rho GTPase-activating protein 3
- Rop guanine nucleotide exchange factor 4
- Protein IQ-DOMAIN 13
- Protein SHI RELATED SEQUENCE 3
- CLIP-associated protein
- Plasma membrane-associated cation-binding protein 2
- Rac-like GTP-binding protein ARAC4
- Gamma-tubulin complex component 3
Sequence:
MGGQMQQNNAAAATALYDGALPTNDAGDAVMARWLQSAGLQHLASPVASTGNDQRHLPNLLMQGYGAQTAEEKQRLFQLMRNLNFNGESTSESYTPTAHTSAAMPSSEGFFSPEFRGDFGAGLLDLHAMDDTELLSEHVITEPFEPSPFMPSVNKEFEEDYNLAANRQQRQQTEAEPLGLLPKSDKENNSVAKIKVVVRKRPLNKKETAKKEEDVVTVSDNSLTVHEPRVKVDLTAYVEKHEFCFDAVLDEDVSNDEVYRATIEPIIPIIFQRTKATCFAYGQTGSGKTFTMKPLPIRAVEDLMRLLRQPVYSNQRFKLWLSYFEIYGGKLFDLLSERKKLCMREDGRQQVCIVGLQEYEVSDVQIVKDFIEKGNAERSTGSTGANEESSRSHAILQLVVKKHVEVKDTRRRNNDSNELPGKVVGKISFIDLAGSERGADTTDNDRQTRIEGAEINKSLLALKECIRALDNDQLHIPFRGSKLTEVLRDSFVGNSRTVMISCISPNAGSCEHTLNTLRYADRVKSLSKSGNSKKDQTANSMPPVNKDPLLGPNDVEDVFEPPQEVNVPETRRRVVEKDSNSSTSGIDFRQPTNYREESGIPSFSMDKGRSEPNSSFAGSTSQRNNISSYPQETSDREEKVKKVSPPRGKGLREEKPDRPQNWSKRDVSSSDIPTLTNFRQNASETASRQYETASRQYETDPSLDENLDALLEEEEALIAAHRKEIEDTMEIVREEMKLLAEVDQPGSMIENYVTQLSFVLSRKAAGLVSLQARLARFQHRLKEQEILSRKRVPR
Protein: Homeobox protein Hox-C5 (Homeobox protein CP11) (Homeobox protein Hox-3D) (Q00444)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-C4
- Homeobox protein Hox-C6
- Homeobox protein Hox-B6
- Homeobox protein Hox-D4
- Homeobox protein Hox-A7
- Homeobox protein Hox-B5
- Homeobox protein Hox-B4
- Homeobox protein Hox-A6
- Homeobox protein Hox-B7
- Homeobox protein Hox-A5
Sequence:
MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPPPAPSNSLHGVDMAANPRAHPDRPACSAAAAPGHAPGRDEAAPLNPGMYSQKAARPALEERAKSSGEIKEEQAQTGQPAGLSQPPAPPQIYPWMTKLHMSHETDGKRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL
Protein: Non-structural glycoprotein 4 (NSP4) (NCVP5) (NS28) (P04512)
Organism: Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both))
Function: Plays an essential role in the virus replication cycle by acting as a viroporin. Creates a pore in the host reticulum endoplasmic and as a consequence releases Ca(2+) in the cytoplasm of infected cell. In turn, high levels of cytoplasmic calcium trigger membrane trafficking and transport of viral ER-associated proteins to viroplasms, sites of viral genome replication and immature particle assembly.
Subcellular location: Host rough endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P08434, ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Host membrane, host caveola {ECO:0000255|HAMAP-Rule:MF_04091, ECO:0000269|PubMed:17376898}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Secreted {ECO:0000255|HAMAP-Rule:MF_04091, ECO:0000269|PubMed:17035333}. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain. {ECO:0000255|HAMAP-Rule:MF_04091}.
Interaction partners:
Sequence:
MEKLTDLNYTLSVITLMNNTLHTILEDPGMAYFPYIASVLTGLFALNKASIPTMKIALKTSKCSYKVVKYCIVTIFNTLLKLAGYKEQITTKDEIEKQMDRVVKEMRRQLEMIDKLTTREIEQVELLKRIYDKLTVQTTGEIDMTKEINQKNVRTLEEWESGKNPYEPREVTAAM
Protein: TRAF6 (Q9UAC4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MQRVQADQKPARMHQHAHTHSHAHSLQHAEEKEHNSNEMTTNLSSTGRIAAGSSATPSAQREGGASGDPTPPKSLALNQNHHYAPGSDTSGEQEEELLDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCPMDNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPSCPYRRQQEPQEEKCPFAKIKCDFVGRPETNQLEEHLKADMPHHMQLMLQAFQQTAIATWQPHKPSTSGAAVENGHGQQQLPPPPPYANGVDEQIVQTMYQRIVVLEQRTREQETRLENMQKQLRLARQQAPVDSRYSNGTIVWRIEQLGALVARLRANANNQVYSHECYTSPHGYKFCARLNIQPRKPHVLSLHVHLMQSENDYHLDWPFKGRIKLCMVHPADATLSQHDTIMTKPEILAFHKPREAISTRGFGFLEYANISNIIQLGFCADDRLLIKIEINIV
Protein: Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor) (O75901)
Organism: Homo sapiens (Human)
Function: May play a role in regulating vesicuar trafficking in cells.
Subcellular location: Endosome. Note=Accumulates on perinuclear endosomes. {ECO:0000250}.
Interaction partners:
- Peptidyl-glycine alpha-amidating monooxygenase
- Ras association domain-containing protein 7
- Ras-related protein Rab-11A
Sequence:
MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEHEATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAFLPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSHDRDNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSFSEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCIDINEDAEGEAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELLAKEFNSLHISNKDGCQLKENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHSQDSETTVGDVVLLST
Protein: Gibberellin 20 oxidase 2 (OsGA20ox2) (EC 1.14.11.-) (GA 20-oxidase 2) (Gibberellin C-20 oxidase 2) (Os20ox2) (Protein semidwarf-1) (Q0JH50)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Key oxidase enzyme in the biosynthesis of gibberellin that catalyzes the conversion of GA53 to GA20 via a three-step oxidation at C-20 of the GA skeleton. Catalyzes the conversion of GA12 to GA9 via a three-step oxidation at C-20 of the GA skeleton. Contributes to the promotion of internode elongation in response to submergence via ethylene and gibberellin signalings.
Interaction partners:
- DELLA protein SLR1
Sequence:
MVAEHPTPPQPHQPPPMDSTAGSGIAAPAAAAVCDLRMEPKIPEPFVWPNGDARPASAAELDMPVVDVGVLRDGDAEGLRRAAAQVAAACATHGFFQVSEHGVDAALARAALDGASDFFRLPLAEKRRARRVPGTVSGYTSAHADRFASKLPWKETLSFGFHDRAAAPVVADYFSSTLGPDFAPMGRVYQKYCEEMKELSLTIMELLELSLGVERGYYREFFADSSSIMRCNYYPPCPEPERTLGTGPHCDPTALTILLQDDVGGLEVLVDGEWRPVSPVPGAMVINIGDTFMALSNGRYKSCLHRAVVNQRRERRSLAFFLCPREDRVVRPPPSAATPQHYPDFTWADLMRFTQRHYRADTRTLDAFTRWLAPPAADAAATAQVEAAS
Protein: Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) (P02112)
Organism: Gallus gallus (Chicken)
Function: Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D.
Interaction partners:
- Hemoglobin subunit alpha-A
- Hemoglobin subunit alpha-D
- Hemoglobin subunit pi
- Beta-H globin
- BCL11 transcription factor A
- HBS1 like translational GTPase.
Sequence:
MVHWTAEEKQLITGLWGKVNVAECGAEALARLLIVYPWTQRFFASFGNLSSPTAILGNPMVRAHGKKVLTSFGDAVKNLDNIKNTFSQLSELHCDKLHVDPENFRLLGDILIIVLAAHFSKDFTPECQAAWQKLVRVVAHALARKYH
Protein: DNA replication licensing factor MCM7 (EC 3.6.4.12) (Cell division control protein 47) (Minichromosome maintenance protein 7) (P38132)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Cell division cycle protein CDT1
- Origin recognition complex subunit 2
- DNA replication complex GINS protein PSF2
- DNA polymerase alpha-binding protein
- DNA replication licensing factor MCM4
- Cell division control protein 6
- Chromosome segregation in meiosis protein 3
- Cell division control protein 45
- Cell division control protein 7
- DNA replication licensing factor MCM6
Sequence:
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKGPKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAIDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDALREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLSNCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDIDLQDA
Protein: Probable calcium-binding protein CML28 (Calmodulin-like protein 28) (Q9SRP7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- Probable calcium-binding protein CML32
- Probable calcium-binding protein CML33
- Probable calcium-binding protein CML34
- Probable calcium-binding protein CML48
- Proton pump-interactor 2
- Probable calcium-binding protein CML14
- Serine/threonine-protein phosphatase PP1 isozyme 3
- Probable calcium-binding protein CML13
- Peptide methionine sulfoxide reductase B4
- Probable calcium-binding protein CML35
Sequence:
MADATEKAEHDRIFKKFDANGDGKISAAELGDALKNLGSVTHEDIKRMMAEIDTDGDGYISYQEFIDFASANRGLMKDVAKIF
Protein: ADP-ribosylation factor 2 (P51823)
Organism: Oryza sativa subsp. japonica (Rice)
Function: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Subcellular location: Golgi apparatus.
Interaction partners:
- Os05g0392000 protein
- Os05g0392050 protein
- Expressed protein
- Os10g0372500 protein
- Kinesin-like protein KIN-14I
- ARF GAP-like zinc finger-containing protein ZIGA2, putative, expressed
- Os11g0209700 protein
- Coatomer subunit gamma-2
- Coatomer subunit gamma-1
- Os05g0210600 protein
Sequence:
MGLTFTKLFSRLFAKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIANKA
Protein: AIP3 domain-containing protein (B3WFT8)
Organism: Caenorhabditis elegans
Interaction partners:
- Transthyretin-like family protein
Sequence:
MSRYPPLVTKKEIIYRRFIDDHNERFDNIVRNPTSYPPRAPKPERPQNLVVSHNYHSDVEAEYQLSKINKKLDRIIEILRSPSTKKTSQEPPIIDVARQEQTRQYKDICDRLDKLEAELTGKTQFVAPLQNEISLLTNKVHELAQIQEGLRVKLVSSNIAGEDIDELLKVINETRRDMEEKIGNIKQLSDGNYIHLEDKLDGYLRNQHGIQLQVDHLMQLLTHSSRPASAIGSRPGSAAEKMSSVSRSSSKSSNLKANLVMPTRRSPPPKTPSEASYASTRPKTERSSSHKSASTVTSSATITTLDSAKRKPLAKNASPKPPRSPVLEVLERTKSIETMNEIHTSQKLDELAIETSSSGSYIAPLPINGRRDSQPANILLTQKY
Protein: Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (A0A1D8PCX8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:35613268}.
Interaction partners:
- Small ribosomal subunit protein uS14
- Elongation factor 2
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL24
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL39
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein uL14
Sequence:
MSQVAPKWYQSEDVPAPKQTRKTARPQKLRASLVPGTVLILLAGRFRGKRVVYLKNLEDNTLLVSGPFKVNGVPLRRVNARYVIATSTKVNVSGVDVSKFNVEYFAREKSSKSKKSEAEFFNESQPKKEIKAERVADQKSVDAALLSEIKKTPLLKQYLAASFSLKNGDRPHLLKF
Protein: Nuclear receptor coactivator 4 (B1H215)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Ferritin heavy chain
- Ferritin light chain 1
- Coiled-coil domain containing 6
- Proto-oncogene tyrosine-protein kinase receptor Ret
Sequence:
MNTSLEQSGCCSSRETLLRCSDARRELELAIGGVLRAEQQMKDNLREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLYWLMGQFNCLIHQLEITQNKDLANQVALCLERLGSLTLKPEDSTVLLFEADASALRQTITTFGSLKTIQIPEHLMAHPSSSSVRPFLEKRGYTQVPEQKSASSGTAVSLSEWLLVSKPAIGPQAPYVPSTNPQDWLTPKQTLENSQTSARICSDAWGNLKGLENWLLNSHQQEIPGKPSSSKCNSHCSTSSFSTEDEKVEDVEVLDQDELDLSDWLVTPQEPRDLEKPVNGRSDTSDKFKLLFQVFREPYNVNDWLVKPDSCTNCQGNQPRGVEIENLGNLKCLNDHLEAKKSLPVPGVITEGWLVQNHQDTCKVEEVCKANEPCTSFAECVCDDSCEKEAMHKWLLKKEGKDKNGMPMGPKSESEKHRESLSLWLCPSRNELTEHAKTPKTTAPARIADSFHIIRNSSLSEWLIGPTCKGGGPKEVPNMEERASKEMLKSPMATYWRPFNTADWVLPGKKVGNLSQFSSGEDKWLLRKKAQEVFLNSPLQEERNFRSDCYGLPAVCDLFACMQLKVDKDKWLYRAPLQM