wanglab/gogpt-training-data huggingface dataset:
Protein: Pituitary homeobox 2 (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (rPtx2) (Q9R0W1)
Organism: Rattus norvegicus (Rat)
Function: Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach (By similarity).
Subcellular location: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:P97474}.
Interaction partners:
- Catenin beta-1
- Forkhead box C1.
Sequence:
MNCMKGPLPLEHRAAGTKLSAASSPFCHHTQALAMASVLAPGQPRSLDASKHRLEVHTISDTSSPEVAEKDKGQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
Protein: E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1) (RING-type E3 ubiquitin transferase COP1) (P43254)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways. Mediates the ubiquitination-dependent degradation of HY5 in the darkness during seedling development (e.g. hypocotyl growth). Represses CIP7 in darkness.
Subcellular location: Nucleus {ECO:0000269|PubMed:10072396, ECO:0000269|PubMed:10480941, ECO:0000269|PubMed:26474641}. Cytoplasm {ECO:0000269|PubMed:10072396, ECO:0000269|PubMed:10480941}. Note=Localizes to the nucleus in darkness but is gradually relocated to the cytoplasm upon illumination. Localizes to subnuclear foci (speckle) and in dispersed nuclear localization in the dark. {ECO:0000269|PubMed:10072396, ECO:0000269|PubMed:10480941}.
Interaction partners:
- Cryptochrome-1
- Transcription factor HY5
- Protein SUPPRESSOR OF PHYA-105 1
- Cryptochrome-2
- Cullin-4
- Light-mediated development protein DET1
- Transcription factor HY5-like
- Ultraviolet-B receptor UVR8
- Protein EARLY FLOWERING 3
- Protein SPA1-RELATED 4
Sequence:
MEEISTDPVVPAVKPDPRTSSVGEGANRHENDDGGSGGSEIGAPDLDKDLLCPICMQIIKDAFLTACGHSFCYMCIITHLRNKSDCPCCSQHLTNNQLYPNFLLDKLLKKTSARHVSKTASPLDQFREALQRGCDVSIKEVDNLLTLLAERKRKMEQEEAERNMQILLDFLHCLRKQKVDELNEVQTDLQYIKEDINAVERHRIDLYRARDRYSVKLRMLGDDPSTRNAWPHEKNQIGFNSNSLSIRGGNFVGNYQNKKVEGKAQGSSHGLPKKDALSGSDSQSLNQSTVSMARKKRIHAQFNDLQECYLQKRRQLADQPNSKQENDKSVVRREGYSNGLADFQSVLTTFTRYSRLRVIAEIRHGDIFHSANIVSSIEFDRDDELFATAGVSRCIKVFDFSSVVNEPADMQCPIVEMSTRSKLSCLSWNKHEKNHIASSDYEGIVTVWDVTTRQSLMEYEEHEKRAWSVDFSRTEPSMLVSGSDDCKVKVWCTRQEASVINIDMKANICCVKYNPGSSNYIAVGSADHHIHYYDLRNISQPLHVFSGHKKAVSYVKFLSNNELASASTDSTLRLWDVKDNLPVRTFRGHTNEKNFVGLTVNSEYLACGSETNEVYVYHKEITRPVTSHRFGSPDMDDAEEEAGSYFISAVCWKSDSPTMLTANSQGTIKVLVLAA
Protein: Fibroblast growth factor 16 (FGF16) (Q2HXK8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a crucial role in pectoral fin bud outgrowth.
Subcellular location: Secreted {ECO:0000250|UniProtKB:O54769}.
Interaction partners:
- Fibroblast growth factor receptor 3
- Fibroblast growth factor receptor 1-A
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor.
- receptor protein-tyrosine kinase
- Fibroblast growth factor 23
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor receptor, beta polypeptide
- receptor protein-tyrosine kinase
Sequence:
MAEVAGFLGSIDLDLQAFPALGNVPLSDGLNERLGLIEGRLQRGSLTDFGHLKGILRRRQLYCRTGFQLEIFPNGTVHGTRQDHSRFGILEFISLAVGLVSIRGVDAGLYLGMNEKGELYGSKKLTAECVFREQFEENWYNTYASTLFKHADTGRYYYVALNKDGSPREGSRTKKHQKLTHFLPRPVEIEKIPQAYRELFQHR
Protein: Anon1A3 (Q9TW87)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
GVENLPSVAEAKQNHVDEVKPISEEPGNSSEEVPKAEEPLKSSGETSENGAATETAAAPKEPASVMDVDEDETLVENTPSANKEKALDDEKEPEQKSEEHAAAVLESKEQNEPAKEPTPEPMEVDGSSKGSSDTAQVDTPAIENVSAAPETEAAAKTTESSNDVVEVATEGKETVLEVPAAEPKEAESTVESAEELTETSTVVVTEPKEAASCEEEPSKVVDSAEPKEAESNTDESATPVPIDVSTAPASNDVSKPLEIDTTLVKTADSPAKEPQEICEVKKAEINVNGEPKIVNSSAEVGENAAPKVCN
Protein: EP1-like glycoprotein 1 (Q9ZVA1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:18796151}.
Interaction partners:
- Serine carboxypeptidase-like 43
- Eukaryotic aspartyl protease family protein
- Uncharacterized protein
- F3F9.4
- Non-specific lipid-transfer protein 9
- Non-specific lipid transfer protein GPI-anchored 1
- Probable pectinesterase/pectinesterase inhibitor 41
- At5g38980
- SKU5-similar 6
- Early nodulin-like protein 19
Sequence:
MLRFDYLLITALAISTVSVVMAQVPPEKQFRVLNEPGYAPYITEYDASYRFLNSPNQNFFTIPFQLMFYNTTPSAYVLALRVGTRRDMSFTRWIWDANRNNPVGDNSTLSFGRNGNLVLAELNGQVKWQTNTANKGVTGFQILPNGNMVLHDKHGKFVWQSFDHPTDTLLVGQSLKVNGVNKLVSRTSDMNGSDGPYSMVLDNKGLTMYVNKTGTPLVYGGWTDHDFRGTVTFAVTREFDNLTEPSAYELLLEPAPQPATNPGNNRRLLQVRPIGSGGGTLNLNKINYNGTISYLRLGSDGSLKAFSYFPAATYLEWEETFAFFSNYFVRQCGLPTFCGDYGYCDRGMCVGCPTPKGLLAWSDKCAPPKTTQFCSGGKGKAVNYYKIVGVEHFTGPYVNDGQGPTSVNDCKAKCDRDCKCLGYFYKEKDKKCLLAPLLGTLIKDANTSSVAYIKY
Protein: Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 56) (Q9D0R4)
Organism: Mus musculus (Mouse)
Function: Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization. Plays an essential role in maintaining nucleolar integrity in planarian stem cells. Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex. Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3. Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5. May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:32703285}.
Interaction partners:
- Ribosome production factor 2 homolog
- CCAAT/enhancer-binding protein zeta
- WD repeat-containing protein 74
- Suppressor of SWI4 1 homolog
- Pescadillo homolog
- RNA-binding protein 34
- ATP-dependent RNA helicase DDX24
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- RNA-binding protein 28
- Protein AATF
Sequence:
MEDQEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQSLLHKKATGPVMEQAVRGLVLVPTKELARQAQAMIQQLAAYCARDVRVANVSAAEDSASQRAVLMEKPDVVVGTPSRVLSHLQQNTLKLRDSLELLVVDEADLLFSFGFEDELKSLLCHLPRIYQAFLMSATFNEDVQTLKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKALLFVNTLERGYRLRLFLEQFSIPSCVLNGELPLRSRCHIISQFNQGLYDCVIATDAEILGPQVKGKRRGRGSKGNKASDPESGVARGIDFHHVSAVLNFDLPPTAEAYVHRAGRTARANNPGIVLTFVLPAEQPFLGKIEDLLSGEGEAPILLPYQFQMEEIESFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPAALRGLVHPRKKRRKVPFSRKAKKVKAQNPLRDFKHRGKKPKPAAKPS
Protein: Tom22p (Q59LZ9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004572}.
Interaction partners:
- Tom7p
- Translocase of outer membrane 40 kDa subunit
- Mitochondrial import receptor subunit TOM20
- Protein channel
- Tom6p
- Mitochondrial import inner membrane translocase subunit TIM8
- Mitochondrial import inner membrane translocase subunit TIM9
- Mitochondrial import inner membrane translocase subunit TIM23
- Mitochondrial distribution and morphology protein 10
- SAM complex subunit
Sequence:
MVKLTQIDDETQQQFENQSVAKNNHIIDEASSEEESDDDDESDLDDFDFENETLLERIVALKDIVPPEQRESIYNLSSTIGDLFKSSVQNGGKFLWTLTSSSLLLGVPLALAILSETQLQEMERGMSLEKSAQDVLAPGSEAAFGNENKK
Protein: Zinc finger CCCH-type with G patch domain-containing protein (A0A0S2Z6H0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAVEAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPCPFFLEGKCRFKENCRFSHGQVVSLDELRPFQDPDLSSLQAGSACLAKHQDGLWHAARITDVDNGYYTVKFDSLLLREAVVEGDGILPPLRTEATESDSDSDGTGDSSYARGMAAAAEPRSQEVVGSDAVDSGTCSSAFAGWEVHTRGIGSRLLTKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLDQCVETLQKQTRVGKAGTNKPPRCRGRGARPGGRPAPRNVFDFLNEKLQGQAPGALEAGAAPAGRRSKDMYHASKSAKRALSLRLFQTEEKIERTQRDIRSIQEALARNAGRHSVASAQLQEKLAGAQRQLGQLRAQEAGLQQEQRKADTHKKMTEF
Protein: Mediator of RNA polymerase II transcription subunit 6 (F4IXJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 10a
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 10b
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 7a
- Mediator of RNA polymerase II transcription subunit 31
- Cyclin-dependent kinase E-1
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 22a
Sequence:
MDSSLLSAATADTFNGNAADQIPPPLQPPGTDMTGISFRDQLWINSYPLDRNYIFDYFALSPFYDTTCNNEILRRRSIHPLDLSHLSKMTGLEYMLTDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGSIYQAPQLCSVFAARVSRTIYNISKAFTDAASKLETIRQDLQVCLVAIVLSLSVNLGSYFLLIFKLMANGEQVYGFNKFLFDTENQNEPAESKPASETVDLKEMKRVDVILTSLYRKLAPPPPPPPFPEGYVSQEALGEKEELGTQGGESQPPQVDPIIDQGPAKRMKF
Protein: Z band alternatively spliced PDZ-motif protein 67, isoform D (M9PF54)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVLDIKMCRFDNVPWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVFYFGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGLPVENLYLPDLPDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPLPTDSEVPNLEQLPETELPDEQPEKSDAPKEVCEPEVVIQTEPGSPDGNEASDGPAGATPPAEPITPVPVKSEEELALERQLADVQRQLAALSSLPSTIQSTLDAVTKQLADLLPTIKLQQQEKQLPQIDENSGNEEQVEEGVTTATNTINTAGETEDAGKDISISGSDNPPVGPCESNEDRCDANDREVAEISRSTDDNRLAKDKKKDLDQEQKQQQQQQQEPLSEEQNFKKQKHNVRFQT
Protein: Autocrine proliferation repressor protein A (PhoPQ-activated pathogenicity-related protein) (Q5XM24)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Inhibitor that slows proliferation of secreting cells (also known as chalone). May function by binding to cell surface receptors. Requires cfaD for activity. Overexpression slows proliferation.
Subcellular location: Secreted {ECO:0000269|PubMed:18550798, ECO:0000269|PubMed:19187549}.
Interaction partners:
- Counting factor associated protein D
- Rho GTPase-activating protein gacA
- Guanine nucleotide-binding protein alpha-8 subunit
- Metabotropic glutamate receptor-like protein H
- Serine/threonine-protein kinase pakD
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN
- Probable basic-leucine zipper transcription factor N
Sequence:
MSKLLILLLLSLVASIFSTPLDDYVNAPDDTYKWTLNNTIEYETFTGYILELTSQTWMAEKSDWPVWKHWVSICVPKGVTTTTTFIYVDGGSNDNWKVPGSMDQTIEIVCLSSGSVSVGLTQIPNQPIIFNNDGVQRFEDDLVAYTWRQFLGNTSEPLWLARLPMTKAVVKCMDAVQEFGKTIGYNSENFVIAGASKRGWTTWLAGVVDPRIIAIVPIVMPILNMIPNMGHQFYAYGEWSFALNDYTGQGVMDYLNGPQMVELAAIVDPFSYRDRYTMPIYAIASSDDEFFLPDSPQFFWNNLTATPEKHLRIVPNAEHSLMGHQIDIILSIVTFVRLLITNQPRPTFTWDITYSEDLNSGTIVLTVPEGGIIPYKVKVWTAVTESTTRRDFRIITCMDITKCIQFIIWDPSDITPTSTGVYSITLSKPDAGWRAFFLEAEYLYAKNSIDDEYTLKFTSEVAIVPNTLPFGSCSEYNACGDGSQGDSASSTATL
Protein: Natural killer cell receptor NKG2A (Q9WU31)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MSNERVTYAELKVAKNSRNQHRKPRGPRSSISVIEQEIIYSDFSFQNPSQEHPWICRNCPCKGFPSPPEKLIAGTLGLICFVLIVAVVVITTVATPYNEANAQINSSMTRTHRDINYTLSSAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLVSCISKNCSLLHIDSEEEQDFLQSLSLVSWTGILRKGRGQPWVWKKDSIFKPKIAEILHDECNCAMMSASGLTADSCTTLHPYLCKCKFPI
Protein: Selenoprotein F/M domain-containing protein (Q387A8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSASCYLPFVACFLSRFARFPPHLFNLLCCWTPFTILRIISHNNKKEDMMCNSFVALLVSLALSRGSFADVDVGDSKGRPADECRLLGFDKPSVRCRHCTLLKQHTTNFTLYEECLACCVDEKVPQLLWYATARLVVKSKSRDEPDREVDKFLAKYRNKFGNRLQVVNSAIGQPTHLIMVGERGTRDAQWVVEDWSVSSLHDYLVRAFNMETEELL
Protein: Guanine nucleotide exchange factor VAV2 (VAV-2) (P52735)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Interaction partners:
- Lymphocyte cytosolic protein 2
- Tyrosine-protein kinase SYK
- Cell division control protein 42 homolog
- Catenin delta-1
- Transforming protein RhoA
- CD44 antigen
- B-cell linker protein
- Ras-related C3 botulinum toxin substrate 2
- SH3 domain-binding protein 2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Sequence:
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
Protein: Parathyroid hormone 2 receptor (PTH2 receptor) (P70555)
Organism: Rattus norvegicus (Rat)
Function: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Tuberoinfundibular peptide of 39 residues
- Parathyroid hormone
- Parathyroid hormone/parathyroid hormone-related peptide receptor
- Guanine nucleotide-binding protein G
Sequence:
MPWLEALPYICGWLILRSCLLVGAQLDSDGTITIEEQIVLVMKAKMQCELNITAQFQEGEGNCFPEWDGLICWPRGTAGKTSAMPCPSYVYDFNHKGVAFRHCTPNGTWDFIHGSNKTWANYSDCFLQPDINIGKQEFFENLYILYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHLHLFVSFMLRAXSIFVKDRVAQAHLGVEALQSLVMQGDLQNFIGGPSVDKSQYVGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVSFFSDTKYLWGFILIGWGFPAVFVVAWAVARATLADTRCWELSAGDRWIYXXPILAAIGLNFILFLNTVRVLATKIWETNAVGHDMRKQYRKLAKSTLVLVLVFGVHYIVFICQPHSFSGLWWEIRMHCELFFNSFQGFFVSIVYCYCNGEVQAEVKKTWTRWNLSIDWKKAPPCGGHRYGSVLTTVTHSTSSQSQMGPSTRLVLISSKPAKTACRQIDSHVTLPGYVWSSSEQDCQPQSTPEETKKGHGRQEDDSPVGESSRPVAFTIDTEGCKGESHPI
Protein: Large ribosomal subunit protein eL37A (60S ribosomal protein L37-A) (L43) (YL35) (YP55) (P49166)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein eL34A
- Ribosome biogenesis protein NOP53
- Small ribosomal subunit protein eS21B
- Eukaryotic translation initiation factor 6
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein uL22A
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL38
Sequence:
MGKGTPSFGKRHNKSHTLCNRCGRRSFHVQKKTCSSCGYPAAKTRSYNWGAKAKRRHTTGTGRMRYLKHVSRRFKNGFQTGSASKASA
Protein: Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (p70 ribosomal S6 kinase beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (Q9Z1M4)
Organism: Mus musculus (Mouse)
Function: Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase mTOR
- Regulatory-associated protein of mTOR
- Small ribosomal subunit protein eS6
- 3-phosphoinositide-dependent protein kinase 1
- Proline-rich AKT1 substrate 1
- Target of rapamycin complex subunit LST8
- Ribosomal protein S6 kinase beta-1
- Eukaryotic translation initiation factor 4B
- RAC-beta serine/threonine-protein kinase
- RAC-gamma serine/threonine-protein kinase
Sequence:
MAAVFDLDLETEEGSEGEGEPEFSPADVCPLGELRAAGLETVGHYEEVELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRHINWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRTPISPLKFSPFEGFRPSPGPPEPMEPSLPPLLPSPPSPPPTSTAPLPIRPPSGTKKSKKGRGRSGR
Protein: High mobility group-T protein (HMG-T) (HMG-T1) (HMG-1) (P07746)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Binds preferentially single-stranded DNA and unwinds double-stranded DNA.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
Sequence:
MGKDPRKPRGKMSSYAYFVQTRREEHKKKHPEASVNFSEFSKKCSERWKTMSAKEKGKFEDLAKLDKVRYEREMRSYIPPKGEKKKRFKDPNAPKRPSSAFFIFCADFRPQVKGETPGLSIGDVAKKLGEKWNNLTAEDKVPYEKKASRLKEKYEKDITAYRNKGKVPVSMPAKAAAPAKDDDDDDDDDDDDEDDDDDDDEDDE
Protein: Zinc finger protein 763 (Q0D2J5)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MDPVACEDVAVNFTQEEWALLDISQRKLYREVMLETFRNLTSIGKKWKDQNIEYEYQNPRRNFRSLIEGNVNEIKEDSHCGETFTQVPDDRLNFQEKKASPEAKSCDNFVCGEVGIGNSSFNMNIRGDIGHKAYEYQDYAPKPYKCQQPKKAFRYHPSFRTQERNHTGEKPYACKECGKTFISHSGIRRRMVMHSGDGPYKCKFCGKAVHCLRLYLIHERTHTGEKPYECKQCVKSFSYSATHRIHERTHTGEKPYECQQCGKAFHSSSSFQAHKRTHTGGKPYECKQCGKSFSWCHSFQIHERTHTGEKPCECSKCNKAFRSYRSYLRHKRSHTGEKPYQCKECRKAFTYPSSLRRHERTHSAKKPYECKQCGKALSYKFSNTPKNALWRKTL
Protein: Delta-A kinase anchor protein 200 (Q9U7E6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGKAQSKRSIDITTDPKKVGEGDEVAGKVEKIDVDQKTDAPAVNGDAATPKEGGDEAAAVEKKETEEHSENDKDLTTEKSAAVAEGDDAVAETAKGEEGSPKEAAAGEDITPLADESIKSKSKKDKVKKKWSFRSISFGKKDKQKPAKSEEATSPTSGTTSPTTAEAEAAPAGDAAVAEPSVATNGEAEKPAETATATSEPASKDEKPAENGSATEQEKQANGETEKAAPAPSTVEEAAKPKPAEEPATVTATESNTTATEEVPVKESQPEPEVVTNGHGAGEALTNGSSNGLAESPVTETAPVADNIPSNVDDEPPHQNGTNGTTTPPPTPVATEIEKGQQIEVDLAKDLKEKNAAAADVTTQEQLPVTCE
Protein: C2H2-type domain-containing protein (Q57XZ4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MASNSSAGKDEWLVGLQQFINTRLRTIPFAAAARVRPQVSVPLPLPNTQYLIDGLMWSVRDCAAWAADAWLCAQSHLHACTQRYAKLNETLTYNAQQRQGGRESKQGEDSAAERERMYDCHALIQDIYIAFCLVDAFLRHMSEVSKSVKELVEKELPRLVADHMPLWEPVHNHYAEEAVEDHRLLFLDLLRSWTVTGLLRPDTQRRIEEYVRHKLKTVREAIADSSRRSNDGQVAVSSRRERQIRAISSGLRAFLYNTAEQKQQQQLSVPLPSEGKSGERTNAVDAVRLTMASFVSAIFPSSRTEAGRYRCAHCGLVLKNASAKTSHYRYHFCSRSYNTELKIVRLPFPALEDYISHEVDCGETGSFVRVTHDMLDVFRSPQNRTVRVRERISREKPK
Protein: AP-3 complex subunit delta (Adaptor-related protein complex 3 subunit delta) (Delta-adaptin 3) (Delta-adaptin) (Q08951)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:10559961, ECO:0000269|PubMed:14562095}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:10559961}; Peripheral membrane protein {ECO:0000305|PubMed:10559961}; Cytoplasmic side {ECO:0000305|PubMed:10559961}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000269|PubMed:10559961}.
Interaction partners:
- AP-3 complex subunit mu
- AP-3 complex subunit beta
- AP-3 complex subunit sigma
- AP-1 complex subunit sigma-1
- AP-2 complex subunit beta
- AP-1 complex subunit beta-1
- Vacuolar protein sorting-associated protein 41
- AP-2 complex subunit sigma
- AP-2 complex subunit mu
- AP-1 complex subunit mu-1-I
Sequence:
MTSLYAPGAEDIRQRLRPFGFFFEKSLKDLIKGIRSHNETPEKLDQFFKQVLSECREEVNSPDLNSKTNAVLKLTYLEMYGFDMAWCNFHILEVMSSNKLQQKRVGYLAASQSFYKDSDILMLATNLLKKDLKYDGNNDVVKVGIALSGLSTIITPSLARDIADDLFTMLNSTRPYIRKKAITALFKVFLQYPEALRDNFDKFVSKLDDDDISVVSAAVSVICELSKKNPQPFIQLSPLLYEILVTIDNNWIIIRLLKLFTNLSQVEPKLRAKLLPKILELMESTVATSVIYESVNCIVKGNMLEEDDFETAMACLERLHTFCDSQDPNLRYISCILFYKIGKINTDFISRFDQLIIRLLSDVDVSIRSKAIELVEGIVDEDNLKAIVQTLMKQFVDEDVVILQTGSIVYEKSKRIPIIIPENYKIKMVNVIISICSADNYSSVNDFEWYNAVIMDLAMLCQDISDKSLGSKIGEQFRNLMIKVPSMREVTIANIIKLISNDNINKQLPTVLRECIWCLGEFSTLVENGNDLIKIMTENISYYSHSVQEVLILALVKVFSNWCNNFQEDKRFEIKMVLKELIEFFENLSYSSTFEVQERSVEVLEFLRLSLEALEEDTEGLPMLLSEVLPSFFNAYELAPIARGTQLKLAVDENLDLETPFLTKEAADELLDEQKSDAISDLMSDISMDEQVELKFVDDSDTSYEEKEKLDDFENPFEIEREKERMSNPYYLGEEDEERTKNSKDLLDLNEEESSDKKPETIRLNRTDNSLNSLSLSTTEISRKKKKGKKKNRVQVLSDEPVIEAAPKRKDAFQKPHDNHSTQNPLKKDKINLRMHSQLENFDFSNFGQSSNAGRGSQEEGNLRKEDELELSRLEANLIVKDEKDNLSDTEEVIVIKKKKKGKKSKSKNKLKTKAKNSPEPNEFLRDQSTDI