wanglab/gogpt-training-data huggingface dataset:
Protein: LD24482p (Q86NK7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSEGVPASPVAIGELKYEDVSQLNFSKLYSPKMKSVYWRYFGFPSNDNNEVITKQNVVCIKCHKVLTNHGNTTNLRAHLQHRHKDLFKELCQEHDIHAPPRKTPRNVSHPPLSKRNVSSRRVKLEFINNRNHDNASDDELDEAAVATAAMQAEEDASSQTMLYETMVPFTYDEAENLVEEEERLVMEPKYGRKRKVATPSSALMHGRVIKHEEGGYAAVANIANLAEALTDIVIKDLRNVDSLYDAGFGEFLRQVLGNSAAMPEPHKIDSLINEMHASKFLEIGEITRDFTSEKPFSLAFEMWVNVEQRRFLSIFHHFLDEETHSVRGMLYATVEYNDYIVFDDLLTDFYLANCTLAIINYDEEEDLLHTYLREKNIPISLCYVSVIDKCLRRVFEIEEVATLLEQVKDLMQRHSTEIASKVSEVPMPTYNEHFPWTLYETLKFFAESISWSEDMDHLVISAKTVTEALSALVIALDTLRGEDIPLCSMLSPITSKILIKKLGIAEQDDPLMMNLKRTISSVLQAHVISNDNLTAAALLDPRFHRLTTIDNLERTVRMLTHKYNINFGGVGEGESNEVAATSSVVAIKSEPRVVDGSAPKKLGLKLLFDSNEIPNPPKRDADSSVESDLKRYRNEVVVQLDESPIEWWLKMGHIYGTLRDLASLYHSVPGVVTLSFKKALRDQIYDFNKRFMLTGSHIDAILFLHHHNN
Protein: Proto-oncogene Mas (P30554)
Organism: Mus musculus (Mouse)
Function: Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (By similarity). Receptor for angiotensin 1-7.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Angiotensinogen
- Angiotensin-converting enzyme 2
- Renin-1
- Angiotensin-converting enzyme
- Type-1 angiotensin II receptor-associated protein
- Renin receptor
- Kininogen-1
Sequence:
MDQSNMTSLAEEKAMNTSSRNASLGSSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHHYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSRSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSAFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV
Protein: Catabolite activator protein (Catabolite gene activator) (cAMP receptor protein) (cAMP regulatory protein) (E0SJP4)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Interaction partners:
- RNA polymerase sigma factor RpoD
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit omega
- Adenylate cyclase
Sequence:
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEDGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMARRLQVTSQKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR
Protein: Reticulon (A0A0R4IF59)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU210713}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU210713}.
Interaction partners:
Sequence:
MEDTDRASSAALGSAPHEESGNEASAAGQTRADEPLLDAEETRDEQVTEVTSTQQITEVNTAPQTAEVTSAEQITEVTSAEQTSLTPTTEVNTAQQTAEVTLTNVSAEQITKADPQITEQTDISLTQTTVVTSPEQVTEVTSTSPEHVTEVKADPHITEVTQITEDTSLTLPTEATSPEQVTEVRVDPQITEVTSSTQVTEETSLTQITEVTSPEQVSELKPDPQISEETSLTQTAGVTSVSPEPITEITSAEQTSEETSLTQISEDVTEETSVPPVSGPPPPPPHHPAAAAPPPDRSPAPCNARPPEPCGEPHSELPPAGEPEVSVSVFQTLPSVLQLLYWRDVRASALVLGSLLLLLLFLSCCSVISVLSYSALCLLTLTLSTRVFTAVLQAMRKTEDGHPFRQYLERDVLLSADAVHTHSEALLRRINTALVELRRLFLVEDLVDSLKLAVGLWLLTYVGSWFNGLTLLIIALIGAFSGPIAYERHQSEIDQFISMINTQMREALGKVLAMVPGGKKKSD
Protein: Histone H2B (Q389S5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000451}.
Interaction partners:
- Histone H2A
- Histone H3 variant
- Histone H3, putative
- Histone H4
- Histone H4
- Histone H2A
- Cell division control protein 73 C-terminal domain-containing protein
- SET domain-containing protein
- Plastid-encoded RNA polymerase subunit alpha
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
Sequence:
MATPKSTPAKTRKEAKKTRRQRKRTWNVYVSRSLRSINNQMSMTSRTMKIVNSFVNDLFERIAAEAATIVRVNRKRTLGARELQTAVRLVLPADLAKHAMAEGTKAVSHASS
Protein: hyaluronan synthase (EC 2.4.1.212) (Q8CH93)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Hyaluronidase-1
- UDP-glucose 6-dehydrogenase
- Hyaluronidase-2
Sequence:
MRQDMPKPSEAARCCSGLARRVLTITFALLILGLMTWAYAAGVPLASDPYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVTVAARRAFAKGPLDAATARSVALTISAYQEDPTYLRQCLTSARALLYPRTRLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAEAAGAVGEGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRKKLAANYVPVLPLALWALLLLGGLIRSVAQEVRADWSGPSRAAEAYHLAAGASAYVAYWVIMLTIYWVGVRRLCRRRSGGYRVQV
Protein: Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (A0) (L10e) (P05317)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein eS6A
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS2B
- Large ribosomal subunit protein uL11A
- Elongation factor 2
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL4A
- Large ribosomal subunit protein uL22A
- Large ribosomal subunit protein uL13A
Sequence:
MGGIREKKAEYFAKLREYLEEYKSLFVVGVDNVSSQQMHEVRKELRGRAVVLMGKNTMVRRAIRGFLSDLPDFEKLLPFVKGNVGFVFTNEPLTEIKNVIVSNRVAAPARAGAVAPEDIWVRAVNTGMEPGKTSFFQALGVPTKIARGTIEIVSDVKVVDAGNKVGQSEASLLNLLNISPFTFGLTVVQVYDNGQVFPSSILDITDEELVSHFVSAVSTIASISLAIGYPTLPSVGHTLINNYKDLLAVAIAASYHYPEIEDLVDRIENPEKYAAAAPAATSAASGDAAPAEEAAAEEEEESDDDMGFGLFD
Protein: Aminoaldehyde dehydrogenase 2 (ZmAMADH2) (EC 1.2.1.-) (4-trimethylammoniobutyraldehyde dehydrogenase AMADH2) (EC 1.2.1.47) (Aminobutyraldehyde dehydrogenase AMADH2) (EC 1.2.1.19) (Gamma-guanidinobutyraldehyde dehydrogenase AMADH2) (EC 1.2.1.54) (C6KEM4)
Organism: Zea mays (Maize)
Function: Dehydrogenase that catalyzes the oxidation of several aminoaldehydes. Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively. Catalyzes the oxidation of 4-(trimethylamino)butanal and 4-guanidinobutanal to 4-trimethylammoniobutanoate and 4-guanidinobutanoate, respectively.
Interaction partners:
Sequence:
MAPPQTIPRRGLFIGGAWREPCLGRRLPVVNPATEATIGDIPAGTAEDVEIAVAAARDAFSRDGGRHWSRAPGAVRANFLRAIAAKIKDRKSELALLETLDSGKPLDEASGDMDDVAACFEYYADLAEALDGKQQSPISLPMENFKSYVLKEPIGVVGLITPWNYPLLMATWKVAPALAAGCTTILKPSELASVSCLELGAICMEIGLPPGVLNIITGLGPEAGAPLSSHSHVDKVAFTGSTETGKRIMISAAQMVKPVSLELGGKSPLIVFDDIGDIDKAVEWTMFGIFANAGQVCSATSRLLLHEKIAKKFLDRLVAWAKNIKVSDPLEEGCRLGSVISEGQYEKIKKFISTARSEGATILYGGGRPQHLRRGFFLEPTIITDVSTSMQIWQEEVFGPVICVKEFRTESEAVELANDTHYGLAGAVISNDQERCERISKALHSGIIWINCSQPCFVQAPWGGNKRSGFGRELGEWGLDNYLTVKQVTKYCSDEPWGWYQPPSKL
Protein: Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) (P05202)
Organism: Mus musculus (Mouse)
Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
Subcellular location: Mitochondrion matrix. Cell membrane {ECO:0000269|PubMed:7878064}.
Interaction partners:
- Malate dehydrogenase, mitochondrial
- Glutamate dehydrogenase 1, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Alanine aminotransferase 2
- Malate dehydrogenase, cytoplasmic
- Alanine aminotransferase 1
- L-lactate dehydrogenase B chain
- Kynurenine--oxoglutarate transaminase 1
- Kynurenine--oxoglutarate transaminase 3
- Putative aspartate aminotransferase, cytoplasmic 2
Sequence:
MALLHSSRILSGMAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVTK
Protein: Chromobox protein homolog 2 (M33) (Modifier 3 protein) (P30658)
Organism: Mus musculus (Mouse)
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression (By similarity).
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:9312051}. Chromosome {ECO:0000269|PubMed:16537902}. Note=Localizes to the inactivated X chromosome in females. {ECO:0000269|PubMed:16537902}.
Interaction partners:
- E3 ubiquitin-protein ligase RING2
- Polycomb group RING finger protein 2
- Polycomb complex protein BMI-1
- E3 ubiquitin-protein ligase RING1
- Chromobox protein homolog 8
- Polyhomeotic-like protein 3
- Polycomb group RING finger protein 1
- Chromobox protein homolog 7
- Polycomb group RING finger protein 6
- E3 SUMO-protein ligase CBX4
Sequence:
MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDPRLLLAFQKKEHEKEVQNRKRGKRPRGRPRKHTVTSSCSRRSKLKEPDAPSKSKSSSSSSSSTSSSSSSDEEEDDSDLDSKRGPRGRETHPVPQKKAQILVAKPELKDPIRKKRGRKPLPPEQKAARRPVSLAKVLKTTRKDLGTSAAKLPPPLSAPVAGLAALKAHTKEACGGPSTMATPENLASLMKGMAGSPSRGGIWQSSIVHYMNRMSQSQVQAASRLALKAQATNKCGLGLDLKVRTQKGGELGGSPAGGKVPKAPGGGAAEQQRGNHSGSPGAQLAPTQELSLQVLDLQSVKNGVPGVGLLARHAPAKAIPATNPATGKGPGSGPTGANMTNAPTDNNKGEKLTCKATALPAPSVKRDTVKSVAASGGQEGHTAPGEGRKPPALSELSTGEENSSSDSDPDSTSLPSAAQNLSVAIQTSQDWKPTRSLIEHVFVTDVTANLITVTVKESPTSVGFFNLRHY
Protein: Peroxisomal multifunctional enzyme type 2 (DmMFE-2) [Includes: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.119)] (Q9VXJ0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids.
Subcellular location: Peroxisome {ECO:0000250|UniProtKB:P51659}.
Interaction partners:
- Sterol carrier protein 2
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase 1
- propanoyl-CoA C-acyltransferase
- GEO07753p1
- Catalase
Sequence:
MSSSDGKLRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEAVADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARNNVLCNVIVPTAASRMTEGILPDILFNELKPKLIAPVVAYLCHESCEDNGSYIESAAGWATKLHMVRGKGAVLRPSLDDPVTIEYVKDVWSNVTDMSKAKHLGAIAEASGTLLEVLEKLKEGGGDAIEDAFEFNSKELITYALGIGASVKNAKDMRFLYENDADFAAIPTFFVLPGLLLQMSTDKLLSKALPNSQVDFSNILHGEQYLEIVDDLPTSGTLLTNGKVFDVMDKGSGAVVVTNSESFDESGRLLVRNQSTTFIVGAGKFGGKKDPIAGVVPLQPAPNRQPDATVQYTTSEDQAALYRLSGDKNPLHIDPQMALLAGFKTPILHGLCTLGFSVRAVLAQFADNNPALFKAVKVRFSGPVIPGQTLRVDLWKQGTRINFRTVVVETGKEVISGAYVDLKSSQAKL
Protein: Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) (Q9TUP7)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11282968}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Hypocretin neuropeptide precursor
- Hypocretin receptor 1
Sequence:
MSGTKLEDSPPCRNWSSAPELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALVGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTMLPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPASQPRGPGQQTKSRISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNVSKLSEQVVLTSISTLPAANGAGPLQNW
Protein: ATPase family AAA domain-containing protein 3A homolog (Belphegor protein) (Q9VEX6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required to maintain the proper number of mitochondria in neurons and muscles.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9NVI7}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q9NVI7}.
Interaction partners:
- Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
- Complex I intermediate-associated protein 30, mitochondrial
Sequence:
MSWLLGRNRQQPQPDQTAGFSEGGGAADPEGRTAGEKSGDSQLSRAERKAMEAYRFDSSALERAADAAKTLERSKHAREALELSKMQEATRQTEYNTKVKEYEAHIEQAKVEQKRIDHEERRKTLIEETKQQQQRAQYQDQLSRKRYEDQLLQQQRVQEENLRKQEESVQRQEAMRRQTIEHEIEMKEKNRLKLLEHELRAKARVDRENRDINLEKIRLKAQEHRTTVLEGIKTAGTVIGAGAEAMLTDWDKVLTAAGGLSLLALGVYTAKGATGVVSRYVEARIGKPTLVGETSRFAFLDALKNPLHYLKRLRAKPTDALQGVVLNPKLEERLRDIAIATKNTRINKGMYRNVLMHGPPGTGKTMFAKKLAEHSGMDFAIMTGGDVAPMGKEGVTAIHKVFDWSHTSRRGLLLFVDEADAFLRKRSSEKISEDLRAALNAFLYRTSEQNPKFMLVLASNTPEQFDYAINDRLDEMVEFTLPGLEERERLLRLYFDKYVLQPAAAGAKRFKLDTFDYGKTCSKMAALCEGMSGREISKLGVSWQAAVYASEDGLLTEKMVLDRCYSAAQQHKQKMAWLSDQERADHKSITGTAAPPLTLTAKKL
Protein: Short stature homeobox 2 (Short stature homeobox protein 2) (Q7SZN8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4.
- T-box transcription factor 18.
- T-box transcription factor 3a
- Insulin gene enhancer protein isl-1
- T-box transcription factor TBX5-A
Sequence:
MEELTAFVSKSFDQKVKEKKEVITYREVLETGSVRNRESLSADPNREEISSITRSGVRSSPVREADMLASERSRDSSSPKLTDGNTDMKERKEDCKPLEDETQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNVPPFSFQVQAQLQLDSAVAHAHHHLHSHLAAHAPYMMFPAPPFGLPLATLAAESASAASVVAAAAAAKTTNKNSSIADLRLKAKKHAAALGL
Protein: Spindle-defective protein 5 (P91349)
Organism: Caenorhabditis elegans
Function: Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12431374, ECO:0000269|PubMed:17115027}. Note=Component of the centrosome. First expressed at two different foci in early postmeiotic one-cell stage embryos, prior to pronuclear migration but after the sperm-donated centriole duplication. These two foci greatly increase in size prior to and during mitosis. In metaphase, it is localized throughout centrosomes. In late anaphase or telophase, it surrounds a central core devoid of microtubules. Its localization is independent of microtubules and other centrosomal proteins (PubMed:12431374). Recruitment to the centrosome during prophase of the 1-cell embryo is regulated by the cye-1/cdk-2 complex (PubMed:17115027). {ECO:0000269|PubMed:12431374, ECO:0000269|PubMed:17115027}.
Interaction partners:
- Spindle-defective protein 2
- Zygote defective protein 9
- Serine/threonine-protein kinase plk-1
- TPX2 domain-containing protein
- Regulator of spindle assembly protein 2
- Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1
- Spindle assembly abnormal protein 4
- PeriCentriolar MatriX Deficient
- Aurora kinase
- Tubulin gamma chain
Sequence:
MEDNSVLNEDSNLEHVEGQPRRSMSQPVLNVEGDKRTSSTSATQQQVLSGAFSSADVRSIPIIQTWEENKALKTKITILRGELQMYQRRYSEAKEASQKRVKEVMDDYVDLKLGQENVQEKMEQYKLMEEDLLAMQSRIETSEDNFARQMKEFEAQKHAMEERIKELELSATDANNTTVGSFRGTLDDILKKNDPDFTLTSGYEERKINDLEAKLLSEIDKVAELEDHIQQLRQELDDQSARLADSENVRAQLEAATGQGILGAAGNAMVPNSTFMIGNGRESQTRDQLNYIDDLETKLADAKKENDKARQALVEYMNKCSKLEHEIRTMVKNSTFDSSSMLLGGQTSDELKIQIGKVNGELNVLRAENRELRIRCDQLTGGDGNLSISLGQSRLMAGIATNDVDSIGQGNETGGTSMRILPRESQLDDLEESKLPLMDTSSAVRNQQQFASMWEDFESVKDSLQNNHNDTLEGSFNSSMPPPGRDATQSFLSQKSFKNSPIVMQKPKSLHLHLKSHQSEGAGEQIQNNSFSTKTASPHVSQSHIPILHDMQQILDSSAMFLEGQHDVAVNVEQMQEKMSQIREALARLFERLKSSAALFEEILERMGSSDPNADKIKKMKLAFETSINDKLNVSAILEAAEKDLHNMSLNFSILEKSIVSQAAEASRRFTIAPDAEDVASSSLLNASYSPLFKFTSNSDIVEKLQNEVSELKNELEMARTRDMRSPLNGSSGRLSDVQINTNRMFEDLEVSEATLQKAKEENSTLKSQFAELEANLHQVNSKLGEVRCELNEALARVDGEQETRVKAENALEEARQLISSLKHEENELKKTITDMGMRLNEAKKSDEFLKSELSTALEEEKKSQNLADELSEELNGWRMRTKEAENKVEHASSEKSEMLERIVHLETEMEKLSTSEIAADYCSTKMTERKKEIELAKYREDFENAAIVGLERISKEISELTKKTLKAKIIPSNISSIQLVCDELCRRLSREREQQHEYAKVMRDVNEKIEKLQLEKDALEHELKMMSSNNENVPPVGTSVSGMPTKTSNQKCAQPHYTSPTRQLLHESTMAVDAIVQKLKKTHNMSGMGPELKETIGNVINESRVLRDFLHQKLILFKGIDMSNWKNETVDQLITDLGQLHQDNLMLEEQIKKYKKELKLTKSAIPTLGVEFQDRIKTEIGKIATDMGGAVKEIRKK
Protein: Protein MFI (Mitochondrial fission factor interactor) (Protein C11orf65 homolog) (Q9D4W2)
Organism: Mus musculus (Mouse)
Function: Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:30059978}. Mitochondrion outer membrane {ECO:0000269|PubMed:30059978}. Note=Predominantly localizes to the cytosol, with a minor fraction at the outer mitochondrial membrane. {ECO:0000269|PubMed:30059978}.
Interaction partners:
Sequence:
MSVKHIQDNSNQEIAARIIQRAWKTFLNVSVYQHFKSLIDLRRQGEPRQIVRYINPKEAQLLDAAAGVQVRFRLGGVRFPPEIYYKIFTHRHIEDLCANSPRDYTKLPARYTSHNKDDPPQVEDNSGWYRRVENNGWRPVSYRFWMPLESGVVDSTKESEFHFSKLKRKQDLEKKRKIKKIDWMRQMYYMGSLEAKATDNETLGLIHKATKGLIKSIEDGGVDSVMEWEVDEVLNWTNTLNFDEYIASWRETATSNSSANLKDVKLQRIQKSLQSNIYGDEAKQAEESLYDDSTYYENAYTKQFTRLTPDSMFGM
Protein: Gcp-like domain-containing protein (Q9RWB3)
Organism: Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
Interaction partners:
- biotin--[biotin carboxyl-carrier protein] ligase
- tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
Sequence:
MTVSAAPVTPLSVTLALDTATPFLTLAVSWPGGELERVQEVGRASAERLADETRALFGAAGLPFQAQTIVIGTGPGSYTGVRVGASYALGLARVWGAEVRGVSTLESLVRGDGPQAVSLDARKGNVYSAVYEVSAGTVTDTVQPVARRPLAEFEAELSGLPHWRDPAPSGLALLRAGLAHGAKDWELAYL
Protein: Transcription factor bHLH150 (ATBS1 interacting factor 1) (Basic helix-loop-helix protein 150) (AtbHLH150) (bHLH 150) (Transcription factor EN 145) (bHLH transcription factor bHLH150) (Q9M9L6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Atypical bHLH transcription factor probably unable to bind DNA. Negatively regulates brassinosteroid signaling.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:20023194}.
Interaction partners:
- Transcription factor PRE3
- Transcription factor IBH1
- Transcription factor PRE1
- Transcription factor PRE2
- Shaggy-related protein kinase eta
- Transcription factor bHLH49
- Transcription factor HBI1
- Transcription factor PRE6
- Transcription factor PAR1
- Transcription factor PRE4
Sequence:
MSSEQGNGSNPSTSPEVEGTKTIPFRRRLQRGQRVFAPKLMEALRRSRVSSEEAPVRHLSRRWRATTAQKVYSLKLYDALQRSRRSATVRDTADKVLATTARGATRWSRAILVSRFGTSLRRRRNTKPASALAAAIRGSGGSGRRRKLSAVGNRVRVLGGLVPGCRRTALPELLDETADYIAALEMQVRAMTALSKILSELQPSTNLGSAL
Protein: Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM3 (EC 2.7.11.1) (Protein BARELY ANY MERISTEM 3) (O65440)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Necessary for male gametophyte development, as well as ovule specification and function. Required for the development of high-ordered vascular strands within the leaf and a correlated control of leaf shape, size and symmetry. LRR-rich receptor-like kinase (LRR-RLK) involved in the perception of CLE45 peptide ligand which mediates root growth inhibition by repressing protophloem differentiation; this mechanism requires CRN. BRX, BAM3, and CLE45 act together to regulate the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem. Necessary for CLE45 peptide-triggered accumulation of MAKR5 in developing sieve elements.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28607033}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:28607033}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Toll-Interleukin-Resistance
- Vesicle-associated protein 4-2
- Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 4
- Membrane-associated kinase regulator 5
- CLAVATA3/ESR
- Mitochondrial import receptor subunit TOM5 homolog
- RmlC-like jelly roll fold protein
Sequence:
MADKIFTFFLILSSISPLLCSSLISPLNLSLIRQANVLISLKQSFDSYDPSLDSWNIPNFNSLCSWTGVSCDNLNQSITRLDLSNLNISGTISPEISRLSPSLVFLDISSNSFSGELPKEIYELSGLEVLNISSNVFEGELETRGFSQMTQLVTLDAYDNSFNGSLPLSLTTLTRLEHLDLGGNYFDGEIPRSYGSFLSLKFLSLSGNDLRGRIPNELANITTLVQLYLGYYNDYRGGIPADFGRLINLVHLDLANCSLKGSIPAELGNLKNLEVLFLQTNELTGSVPRELGNMTSLKTLDLSNNFLEGEIPLELSGLQKLQLFNLFFNRLHGEIPEFVSELPDLQILKLWHNNFTGKIPSKLGSNGNLIEIDLSTNKLTGLIPESLCFGRRLKILILFNNFLFGPLPEDLGQCEPLWRFRLGQNFLTSKLPKGLIYLPNLSLLELQNNFLTGEIPEEEAGNAQFSSLTQINLSNNRLSGPIPGSIRNLRSLQILLLGANRLSGQIPGEIGSLKSLLKIDMSRNNFSGKFPPEFGDCMSLTYLDLSHNQISGQIPVQISQIRILNYLNVSWNSFNQSLPNELGYMKSLTSADFSHNNFSGSVPTSGQFSYFNNTSFLGNPFLCGFSSNPCNGSQNQSQSQLLNQNNARSRGEISAKFKLFFGLGLLGFFLVFVVLAVVKNRRMRKNNPNLWKLIGFQKLGFRSEHILECVKENHVIGKGGRGIVYKGVMPNGEEVAVKKLLTITKGSSHDNGLAAEIQTLGRIRHRNIVRLLAFCSNKDVNLLVYEYMPNGSLGEVLHGKAGVFLKWETRLQIALEAAKGLCYLHHDCSPLIIHRDVKSNNILLGPEFEAHVADFGLAKFMMQDNGASECMSSIAGSYGYIAPEYAYTLRIDEKSDVYSFGVVLLELITGRKPVDNFGEEGIDIVQWSKIQTNCNRQGVVKIIDQRLSNIPLAEAMELFFVAMLCVQEHSVERPTMREVVQMISQAKQPNTF
Protein: Lactation elevated protein 1 homolog B (Q5TYS0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAAYASRWRTDCLLRLVFKKTRLSKQVCCEVCKASRGCSTTSTGHTSTSAPWPVYGRLVTHYDSLVHFGSLRKDPQQRTALLQLEELTRVLTDYTNIPILLPQPKDCLQNQPTSELQDKVGSRETVNICRPDENVSNEKEDQQEESSKPHPPQGYYIYGNVGTGKTMLMDLFYSFVENRRKKRVHFNGFMLDVHRRIHKLKQSLPKRRIGKMTMYDPIFPVAMEIAEETCLICFDEFQVVDIADAMILKQLFEGLFKCGVVVVATSNRPPEELYKNGLQRAAFVPFIGVLKEYCRIVSLDTGIDFRTREMKPAGRLYYISSEPDAENAVNALFEELAFRQNDVTRPRVLNVQGREVTLSRTCGTIADCSFQELCEQPLGAGDYLEIARCFDTVIIRNVPYLQLGMKDQARRFTTLIDNFYDQKVRVVMLADAPLDRLLDQGQMTGEEARDRLMLDELGLTDEASKRITLFTADEEIFAFQRTVSRLAEMQTEQYWISGDRSQS