wanglab/gogpt-training-data huggingface dataset:
Protein: Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A) (Q9ER38)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm. Endoplasmic reticulum lumen {ECO:0000250}.
Interaction partners:
- Torsin-1A-interacting protein 2
- Torsin-1A-interacting protein 1
- Man
Sequence:
MFLGALWLLLLLPLRPPGAQGQEADEPTPWPSVKGLKEQLRKAGALSKRYWELFSCTLWPDHCEDQETPVPPLGWSLPLWGRRSLDVLTAWLCRFQDCCSGGGDCRISNNLTGLESDLRVRLHGQHLASKLVLRAVKGYLEMPQVGKALALSFHGWSGTGKNFLARILMDNLYRDGMRSDCVKMFISTFHFPHPKYVDTYKEELQRQMQETQWRCHQSTFVFDEAEKLHPGLLELLEPYLEPRSPEARGVEAPRAIFLFLSNLGGSVINEVVLSLLKAGWSREEITTQHLEVPLQAEIMEAADSSFGSSGLLKKHLIDHFIPFLPLEYCHVRLCVRDAFLGQDLPYTEETLDEIAKMMTYVPEEERLFSSQGCKSISQRINLFLP
Protein: Peptide methionine sulfoxide reductase (EC 1.8.4.11) (Ecdysone-induced protein 28/29 kDa) (Methionine-S-sulfoxide reductase) (Peptide-methionine (S)-S-oxide reductase) (P08761)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reduction of methionine sulfoxide in proteins to methionine. Does not catalyze the reverse reaction involving the oxidation of methionine residues.
Interaction partners:
- Methionine-R-sulfoxide reductase B1
- cystathionine gamma-lyase
- EG:132E8.3 protein
- GEO01508p1
- AT22380p
- Thioredoxin-1
- Thioredoxin-T
- Thioredoxin-2
Sequence:
MSLTITSSVTHPELKDLSTVRNEQKELNISPVHDVNVTKATATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPTYRKMGDHTEVLEIDYDPTVISFKELLDLFWNNHEYGLTTPIKRQYASLILYHDEEQKQVAHASKLEEQERRAPEIITTEIASKENFYPAEAYHQKYRLQGHKDLASSLNLSPKLLQTSYVATKLNGYLAGVGGIEQFKAEAETMGLTPTQRQYCYYHVEQNEGQGLYC
Protein: AT15149p (Q8IHC0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
GILFLSLNRLFKRTIENLIEYLFSEMPNFLLHEITRCIESRDQAKMEESPNDTLTADAITSDMLENLSIHDTQESEMLRLLNAELNDLLDLHNKQEFQTIEIRRKRVSCFIEKLVSEREDTLKKLESIRSHLTILQSDLDQSCLISVDPESGPCDLDADAQMLEALRRRLLNLSQLNRELHGKYQRLDTESKKLEARIESESSVLQRNSVVLREIAELICSLGSKEFSYNEIYDESSKENPFCTTIADIFARKFEEEQNQVAINGQLSCQIKGLQENLKDRDNQISQLQSMINSYSDFSENNRLKEEMHVLKQKNCDLSRQLRELPSLLKNQENQSVELCTKYESLMASFEDQCQELKDAKRKAQSLQTRLDQVEQLQDELKTERKILREEVVALKEKEAVSSGRERALQEQQKSAQLEMEKMRTLVRKMQSHLQLDDIRHRESIQRMNETTESLREELRTISENCQQMQIRLNQQTEVNQQQEQIIDSFRKWKDAQVRADEAMRLCAKRAEEHIHMLLDENRTLAEDYRNLFRDYKLLETEIKRVKHAVNCASSSAISCPPPKSGGLTNTEAGNDMARRLQNLTSTSQRIFNQNQTMNDQYCNSLISGSPAGIGQPVAQSILRRSRSSQDQS
Protein: mevalonate kinase (EC 2.7.1.36) (F5GXC0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKD
Protein: Protein MGARP (Corneal endothelium-specific protein 1) (CESP-1) (Hypoxia up-regulated mitochondrial movement regulator protein) (Mitochondria-localized glutamic acid-rich protein) (Ovary-specific acidic protein) (Q8TDB4)
Organism: Homo sapiens (Human)
Function: Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). Plays an inhibitory role during neocortex development by regulating mitochondrial morphology, distribution and motility in neocortical neurons (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16565373, ECO:0000269|PubMed:21447634}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8VI64}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8VI64}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion. {ECO:0000250|UniProtKB:Q8VI64}.
Interaction partners:
Sequence:
MYLRRAVSKTLALPLRAPPNPAPLGKDASLRRMSSNRFPGSSGSNMIYYLVVGVTVSAGGYYAYKTVTSDQAKHTEHKTNLKEKTKAEIHPFQGEKENVAETEKASSEAPEELIVEAEVVDAEESPSATVVVIKEASACPGHVEAAPETTAVSAETGPEVTDAAARETTEVNPETTPEVTNAALDEAVTIDNDKDTTKNETSDEYAELEEENSPAESESSAGDDLQEEASVGSEAASAQG
Protein: Triacylglycerol lipase 4 (EC 3.1.1.3) (Lipase 4) (P36165)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Lipid particle-localized triacylglycerol (TAG) lipase. The lipid droplet/particle is a lipid storage compartment which serves as a depot of energy and building blocks for membrane lipid biosynthesis. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs, releasing and supplying specific fatty acids to the appropriate metabolic pathways. Also has steryl ester (SE) hydrolase and phospholipase A(2) (PLA(2)) activities, and catalyzes the acylation of lysophosphatidic acid (LPA). Contributes to early bud formation in late G1 phase of the cell cycle upon phosphorylation and activation by cyclin-dependent kinase 1 (Cdk1/CDC28).
Subcellular location: Lipid droplet {ECO:0000269|PubMed:16135509, ECO:0000269|PubMed:16267052, ECO:0000269|PubMed:19150427, ECO:0000269|PubMed:21820081, ECO:0000269|PubMed:24868093, ECO:0000269|PubMed:27170177}. Note=Partially retained in the endoplasmic reticulum in cells lacking triacylglycerols. {ECO:0000269|PubMed:27170177}.
Interaction partners:
- Triacylglycerol lipase 5
- Putative lipase ATG15
- Diacylglycerol O-acyltransferase 1
- Sterol esterase TGL1
- Monoglyceride lipase
- Triacylglycerol lipase 2
- Phospholipid:diacylglycerol acyltransferase
- Phosphatidic acid phosphohydrolase 1
- Lysophospholipid acyltransferase
- Triacylglycerol lipase 3
Sequence:
MSSKISDLTSTQNKPLLVTQQLIEKYYEQILGTSQNIIPILNPKNKFIRPSKDNSDVERVEEDAGKRLQTGKNKTTNKVNFNLDTGNEDKLDDDQETVTENENNDIEMVETDEGEDERQGSSLASKCKSFLYNVFVGNYERDILIDKVCSQKQHAMSFEEWCSAGARLDDLTGKTEWKQKLESPLYDYKLIKDLTSRMREERLNRNYAQLLYIIRTNWVRNLGNMGNVNLYRHSHVGTKYLIDEYMMESRLALESLMESDLDDSYLLGILQQTRRNIGRTALVLSGGGTFGLFHIGVLGTLFELDLLPRVISGSSAGAIVASILSVHHKEEIPVLLNHILDKEFNIFKDDKQKSESENLLIKISRFFKNGTWFDNKHLVNTMIEFLGDLTFREAYNRTGKILNITVSPASLFEQPRLLNNLTAPNVLIWSAVCASCSLPGIFPSSPLYEKDPKTGERKPWTGSSSVKFVDGSVDNDLPISRLSEMFNVDHIIACQVNIHVFPFLKLSLSCVGGEIEDEFSARLKQNLSSIYNFMANEAIHILEIGSEMGIAKNALTKLRSVLSQQYSGDITILPDMCMLFRIKELLSNPTKEFLLREITNGAKATWPKVSIIQNHCGQEFALDKAISYIKGRMIVTSSLKTPFQFADSVIGLIKAPEQTSDESKNPENSTLLTRTPTKGDNHISNVLDDNLLESESTNSLLLLRENASTYGRSPSGFRPRYSITSASLNPRHQRRKSDTISTSRRPAKSFSFSVASPTSRMLRQSSKINGHPPPILQKKTSMGRLMFPMDAKTYDPESHELIPHSASIETPAMVDKKLHFGRKSRYLRHMNKKWVSSSNILYTDSDKEDHPTLRLISNFDSDAMIHSDLAGNFRRHSIDGRPPSQATKSSPFRSRPSSSTQHKSTTSFTQ
Protein: CTD nuclear envelope phosphatase 1B (EC 3.1.3.16) (Dullard-like protein) (Serine/threonine-protein phosphatase dullard-B) (Q5U3T3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Nuclear envelope phosphatase-regulatory subunit 1
- CTD nuclear envelope phosphatase 1A
Sequence:
MLKTRQCLLGVRTFHGVTSRIWSFFLYILRKHIRTIIQYQTVRYDILSLSPISRNRLNNVKRKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNNKAILKRRYYRQHCTLDSGSYIKDLSVVHDDLSSVVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFPADVRSVLSRNLHQHRLW
Protein: Uncharacterized protein avahiru (Q6F3E8)
Organism: Amblyomma variegatum (Tropical bont tick)
Interaction partners:
Sequence:
MLKNIVLLLAAGLSGPAVLAKPKWSPLFEEATNALEARSGGHQTAVPKVSKQGLGGDFEEIPSDEIIKRALEDRSGGHQTAVPKISKQGLGGDFEEIPSDEIIERALEARSDGHQTAVPKMSKQGLGGDIEEIPSDEIIERALEARSGGHQTAVPKMSKQGLGGDSEEIPSNEIIERALEARSGGHETAVPKMSKQGLGGDFEEIPSDEIIERALQARG
Protein: Uncharacterized protein (Q384H0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVADVVFVLVVEVFVCCWIESDNGSLLMVSFIYSCVSSRLMFASVKRAVGQYSCFHVICSPRFHSNYVVGVNKAPSWIASPTERRRKFGEECLAEGKERDGDMDVELVPVDVKKLALPLHLTDSIPQDIVDNIVARDRTLVFAPNMKILDLHRRLSRMKYRISVQPLGKVLHFRFFRLCKLSSGMPGDVTVETFRSIQQKLSEYTRFLVMDERWPLELSLEITPIIEHQRKAML
Protein: Homeobox protein SIX1 (Sine oculis homeobox homolog 1) (Q62231)
Organism: Mus musculus (Mouse)
Function: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation (By similarity). Mediates nuclear translocation of EYA1 and EYA2 (By similarity). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (By similarity). Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2. Regulates the expression of CCNA1 (By similarity). Promotes brown adipocyte differentiation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q15475}. Cytoplasm {ECO:0000250|UniProtKB:Q15475}.
Interaction partners:
- Protein phosphatase EYA1
- Protein phosphatase EYA2
- Dachshund homolog 1
- Protein phosphatase EYA4
- Protein phosphatase EYA3
- Paired box protein Pax-2
- Paired box protein Pax-3
- Transcription factor SOX-2
- Histone acetyltransferase KAT7
- Nuclear receptor coactivator 3
Sequence:
MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQSNMGHARSSNYSLPGLTASQPSHGLQAHQHQLQDSLLGPLTSSLVDLGS
Protein: Immunoglobulin-like and fibronectin type III domain-containing protein 1 (EEF1A2-binding protein 1) (KY-interacting protein 1) (Q86VF2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
Interaction partners:
Sequence:
MAGKLRKSHIPGVSIWQLVEEIPEGCSTPDFEQKPVTSALPEGKNAVFRAVVCGEPRPEVRWQNSKGDLSDSSKYKISSSPGSKEHVLQINKLTGEDTDLYRCTAVNAYGEAACSVRLTVIEVGFRKNRKRHREPQEDLRKELMDFRKLLKKRAPPAPKKKMDLEQIWQLLMTADRKDYEKICLKYGIVDYRGMLRRLQEMKKEQEDKMAQYINTISSLRHIRVTKDGNAKFDLELDLKDSQSKIYLYKDGEMIPYGFNNQTKHCLRRLGKRYEFQIQDLRPEDSGIYQVKVEDAVVFSTELEASAIPPRVVVPLAETHCEEQGDAVFECTLSSPCPSAAWHFRHRLLHPSDKYEVYVSPDGLTHRLVVRGARFSDMGPYSLGTGLYTSSAWLVVEAGKDKDLQSTSADHKLQSRRSGKDGRLDIYGERRDATRSSTSRYKPGTGSFSKDAQGPMGHFSQGLADMEVQPGEAATLSCTLTSDLGPGTWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQAGRYTFVAGDQQSEATLTVQDSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQAAWRKDGAEVVGSSDREAQVDLGDGYTRLCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQVIDKPDPPQGPMEVQDCHRAGVCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPADSTTFTDAHVEPGRKYTFRVRAVTSEGAGEALESEEILVAPEALPKAPSAPAILSASSQGITLTWTAPRGPGSAHILGYLIERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRVTAVAPSGPGEPGPPSDAVFARDPMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQGYVVELCSSDSLQWLPCHVGTVPVTTYTAKGLRPGEGYFVRVTAVNEGGQSQPSALDTLVQAMPVTVCPKFLVDSSTKDLLTVKVGDTVRVPVSFEAMPMPEVTWLKDGLPLPKRSVTVTKDGLTQLLIPVAGLSDSGLYTVVLRTLQGKEVAHSFRIRVAACPQAPGPIHLQENVPGTVTAEWEPSPDEAQDVPLHYAVFTRSSAHGPWHEAADRIHTNRFTLLGILPGHEYHFRVVAKNELGASKPSDTSQPWCIPRQRDRFTVKAPCYREPDLSQKPRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSLEGNPAVYSTDLLGVCSLTIPSVSPKDSGEYKAVAENTLGQAVSTATLIVIEPST
Protein: rRNA methyltransferase 1, mitochondrial (Q8W497)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Large ribosomal subunit protein uL29m
- Protein Iojap-related
- Large ribosomal subunit protein mL43
- Pseudouridine synthase family protein
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL21c
- Short integuments 2, mitochondrial
Sequence:
MYCNLTRSQGFPMAIRVSLQQTTIKSCLQFSKSSYLPVKFHLNPKGSTFAHVSTGLVSSRLNSMKIRMLRNPEGVREFSSFDSQRFGKRSSSNSSRGKSGLGSKAYRDKRSGGSGRSSGDSIWVKSDEKPVEERFQRGDRPSWEKRDGRNDSGSDRRSRSRGYGETRNRDSFRGRRDDRISEVEEESKKGGGNSIWVANDDKPAKEQSPRVNNRSSWDDRTRNQNSFSARGDDRITEEAEEETMNHAPEDGDGIVEEEPDNTRWSEIKNRFNRYDVRDQGRDDAAYRNWNRQESWGRKTWQEATESSVPRLEGEVVYGVSPVLAALSVGRREFYALYVQEGLDLSSNNRKKKDKKGFERVLKISEKLGLNIKETSKHDLNMVADNRPHQGLVLDASPLELVKVKELDPISSEEEKYSLWVALDEVTDPQNLGAIIRSAYFFGATGVVVCAKNSAPLSAVVSKASAGSLEVMELRYCKNMMQFLEASAENGWRVVGGSVSPKAVALNEVLPGSPTILVLGNEGTGLRPLVERSCTDLVRISGNMPNEVAVTESDDAEGEGFRSFLAVESLNVSVAAGLFLHHLIGNKASA
Protein: Nuclear receptor coactivator 4 (A0A2I3BRC7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MNTSLEQSGCYSNRETLLRCSDARRELELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLYWTGQFGPEA
Protein: Spermatogenesis-associated serine-rich protein 1 (Q496A3)
Organism: Homo sapiens (Human)
Interaction partners:
- Spermatogenesis-associated protein 3
Sequence:
MSPSMLTGNSPRGCRLPSISSTTCGRQLEKVPEKRDSGMTEVERTYSANCSDFLESKGCFANTTPSGKSVSSSSSVETGPSVSEPPGLPRVSAYVDTTADLDRKLSFSHSDHSSEMSLPEVQKDKYPEEFSLLKLQTKDGHRPEWTFYPRFSSNIHTYHVGKQCFFNGVFLGNKRSLSERTVDKCFGRKKYDIDPRNGIPKLTPGDNPYMYPEQSKGFHKAGSMLPPVNFSIVPYEKKFDTFIPLEPLPQIPNLPFWVKEKANSLKNEIQEVEELDNWQPAVPLMHMLHLSGALDFPRQS
Protein: Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) (A0A0G2QC45)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEIIRSNFKINLPKVYQAIEEADFFAIDGEFSGISDGPSVTALTSGFDTPEERYQKLKKHSMDFLLFQFGLCAFKYDHANSKHVTKSFNFYVFPKPFSRSSPDVKFVCQSSSIDFLASQGFDFNKVFCSGIPYLNQEEERQLREQFDEKRSQANGAGALTKCPVTIPEDQKKFIDQVIEKIEGFLQREEKRTLELNPCTGFQRKLIYQTLSWKYPKGIHVETLETDKKERHIVISKVDEEERKRREQEKYAKEQEELNDAVGFSRVIHAIANSGKLVVGHNMLLDVMHTIHQFYCPLPVDLNEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFDPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSLLSPPKTCVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVQIAVNTSKYAESYRIQTYAEYVGKKQESKQVKRKWTEDSWKEVDRKRPHVPGPCYHTNSFTAAGIVGKRTLSPDPREAGVVDRESEGISDPELEQTDYCADPLPEGRKKAKKLKRMKKEFSLAGSASDSPAVLFEVPDTW
Protein: SCY1-like protein 2 B (Inactive protein kinase SCYL2B) (Q9C9H8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably inactive kinase. Component of the AP2-containing clathrin coat that regulates clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. Together with SCYL2B, required for cell growth, plant growth and development. Essential for polarized root hair development probably by mediating the root hair tip localization of cellulose synthase-like D3 (CSLD3).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:28751315}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:28751315}. Prevacuolar compartment membrane {ECO:0000269|PubMed:28751315}. Note=Colocalizes with the clathrin heavy chain 1 (CHC1). {ECO:0000269|PubMed:28751315}.
Interaction partners:
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- U-box domain-containing protein 28
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- U-box domain-containing protein 30
Sequence:
MSINMKTFTQALARTAAVIEKTVHTTVQEVTGPKALQDYELLDQIGSAGPGLAWKLYAAKARDSTRPQQYPTVCVWMLDKRALSEARVRANLSKAAEDAFLDLIRADAGKLVRLRHPGVVHVVQALDENKNAMALVTEPLFASVANALGNVENVGNVPKDLKSMEMSLLEVKHGLLQISETLNFLHNNANLIHRAISPENVLITSAGSWKLAGFGFAISAAQAGNLDNMQSFHYSEYDVEDSILPVQPSLNYTAPELMRSKSPSAGASSDIFSFGCLAYHLVARKPLFDCNNNVKMYMNTLNYITNESFSSIPSELVSDLQRMLSTNESFRPTALDFTGSNFFRSDARLRALRFLDHLLERDNMQKSEFLKALSDMWKDFDSRVLRYKVLPPLCAELRNLVLQPIILPMVLTIAQSQDRTDFELITLPALVPVLSTASGDTLLLLVKHADLITNKTDSEHLVSHVLPLLLRAYNDNDVRIQEEVLKRSTSVAKQLDGQVVRQAILPRVHGLALKTTVAAVRVNALLCLAELVQTLDKPAAIEILETIQRCTAVDRSAPTLMCTLAVANAILKQYGVEFTAEHVLTLMMPLLTAQQLNVQQFAKYMLFVKDILRKIEEKRGVTVNDSGVPEVKPHSAANGLQFQSSTQIPEKVASAAKSSPAWDEDWGSPSKDSAVGNPASSRHNTNDQFNKSTDQSQPSIMSTLPNKTTAPTTCPAVDIEWPPRQSSSLTAPATDNQTQLNTGTSFASGFDELDPFANWPPRPNNGASVASTGLKNGAASNFSNNLPGGTHFQTANNDNWAFSSASLSSLKPPQQGNQGISANNQDPLNSFGVPKQSQGMPSFTSGSYNNQKPADISSIFGSSKTEPSAMKLAPPPSIAMGRGRGRGRGGTGTSTSKPSGSQPSLLDLL
Protein: DAXX (Q5UDQ8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSASVICVDLSSESDEEMVVPVAETGPARETPVIVDPLRSMHIPSGITITKHQKNVLATNGNMNLSLAESNNNNNTTSLNKNVTPKQINVGTGQKVAWSVSSKAPSPNAVITTVPSHQVRVTPFNPIRLAPGSKIIPASNAMPAKIQPILGMGQPQQQAQAQQPKAIIVGFPKPNTAVAQMAQHQKPLTLQIHQKLIAGQQQHIASISQLQQVSLQQQQPLRPVSIQLQQQQNQRNGSLPGKQQKPLECPVPAQQEKLPRGPLPTKPAEPLSGPLPTEPDEPLGGPLPTRPKPPVRSLQQPVNKNTAIGVQIQQSQEPLGGTLPTRQKPLGGQLLTQQKPPVGSIQQSVKQNTGIGVQIQQIPKVVVGQQPQKVYLNKLQQEQQKIFLGHLQQQQQKTFLGQLQQEQQKILGQLQQQKQQQQQQQKKILGQSQQQKVPLGQPQPQQKLPQQLNNSLVQLQQQHQQRTSVGQLQQQQPHQSQQKNSMVHVKQQPQQQKKISVGQFQQQPQQQQKTSVAQLQQQPQQQQKISVGQLQQQSQQQQKPSVGQLQQQSQQQQTPLVGQLQRQTQQQQKTSAGQFQQQPQQQQKISAGQLQEHSQQQQKTLAGQLQQQAQQQLNTSAGQLQQQQKPPKASLAQQAAAQKQGAGLGQQQQFQSQPQQRTSAGLLQQQQMPQKKIVMQPQLPKTSVVLPRPQQLPKNPLLVAQQQSPKTPLVNSVMGPQFPSQQPSLPVVNQITHKSMTIQRLPMLQTVQKILPKQIAPQQTPPPAHIVQKQTMPNAAMQNPPFAHRPPIVRPMTVAKISPVPTNNKVCIPMKPQMASYVSPTDPTMTAARTLPFRSSQRKTSEAPMTSTHVQGFTASATPPASSGHSTALCRGLNEPLLLNLPPTTSITPQLTPTTTPPPAGPSAAVQQQQLAKAAAIKLNSLPEASISPVNRSPTASAKRIQPITVLKKSDEEWQRHLEQQQQKKHVQLQSSSMTTIVLVESPPTTPPTDKPEPERGPMTVEKSSIKPMATDKQSRAIKRPAVMISTKKSGLVVTEIVDLDEIPDIPPEKRGKECFPPIKNAAKAAPSVNAPFTTEYAALLRLCREVDKSTHMERLVKGELTQYYYSAPESFVMSCGFRNLVTMAMARIRSESYLVYVHLKYVLDELASRRLTKMFPTVRAIPPASQFPLPPASQFPLPPTLTTPKQPAIVKAPGQQTVMAGREQDDEVEEVTLVNVGTVSCEERRRDERIRHFYRTLHAITKRIKMLEEAEVDLNDEDSSYLQLERFKKRACQIYEKICDLKGESKSVRRQLKKPIHFKDSDYPHFNNSLSAFVNRMQDFPDYHDVLQILEKCNKEKELGLAKYEMKRIAYDAFNKVGRMLQSRRKNDLYETVTHYTANGKDPASSDPELLAKLKENNKKQTKISDILEKYALEQDLNAEERQEARLKEKKLKQVKADEEAAKLAALAEDDDKPCTSAQAAAKAAALAALKRGPAARGNVIRKKRAANGRIFKIADDGDDSEEESDSEDDDVEEFVNNFQANSDVSDADSEVEAVTSPKRDALPLAEEEDVIDITRDETGKKNDEGTPNGRLKIMSVSSLNANFVHGQDLHRKPNPMPSAKPVIADQIIISDEES
Protein: Uncharacterized protein (Q389W0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Pre-mRNA-splicing factor SYF1
- Splicing factor 3B subunit 1, putative
- U2 small nuclear ribonucleoprotein B, putative
- PRP8 protein homologue
- Small nuclear ribonucleoprotein Sm D2
- G10 protein
- Uncharacterized protein
- Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein
- U5 small nuclear ribonucleoprotein component, putative
- Sm protein B
Sequence:
MKCELASLIKENAQLGREMRGTPQLRVPQETDVAWRLRRDVLLHSEYPHVAACPEKDVERKDGRAVVVFQESKLQGEPPERTAAQKRSRSDHTAVVSVDPSVLKARASSLGERIVGAAGPSFEPYTAPPSWKMAKVLVGHRGWVWGAAVDPSNSWFATGGGDGVVKVWDLTTGALKLNLTGHKEGVRALSLSTLSPYMFTGSDDHSVKCWDLERNEIIRDFHGHKGSVHCVSTHPSLDIVLSGGRDKTVRVWDVRTRSCVHLLLGHSDSVMSLAVQQEDPQAISGGSDGMVYLWDIASGRAFTRLTRHKKPVRGLALSRQRVLVSCGADNIRVWSLPTGEFLFNASTLDNGKETKKEKEQEPQRWSCCSVSPRNVLAVGSQEGRLLFFDWSHPQQGPYQATKTRSVPGTLPGEGGINGLAFDASGSRLITAESDKSAKVWRTKE
Protein: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (EC 2.4.99.-) (GD1 alpha synthase) (GalNAc alpha-2,6-sialyltransferase V) (ST6GalNAc V) (ST6GalNAcV) (Sialyltransferase 7E) (SIAT7-E) (Q9BVH7)
Organism: Homo sapiens (Human)
Function: Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
- Proheparin-binding EGF-like growth factor
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Sequence:
MKTLMRHGLAVCLALTTMCTSLLLVYSSLGGQKERPPQQQQQQQQQQQQASATGSSQPAAESSTQQRPGVPAGPRPLDGYLGVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWGPSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPDWKPESLAINHPENKPVF
Protein: RING-type domain-containing protein (H2L089)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTDLDTSSAQIRASQSDLSIANSSPRLLESNATTSTACINDVQQPVRRDLSSELLCPLCDQLFDRPVMVTCGHSYCEPCIERHTRDTRACVICKLDVGPFAAMIPSITLDNMVRKLKNQENIESSYDDLFICEEKLQKAPTPPISEEIPAQKMTRSLSQRSKRRLFFSIAGPTICSRKPPMSHKRYTIDEASEVMKSFNQQKYVDLRESSVESDRMLEEMLEKQKQLVWKSVRIARISREKDRAEKTETLMEEVRFFWSIEMQCRHAVEDWKRRKRENDRKRRTDKVVTETLVQKKRRRKVEEEVEEDQMEDRNEDRDEEFDHGEGCSGY
Protein: Phosphoglycerate kinase (EC 2.7.2.3) (Q9CIW1)
Organism: Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MAKLTVKDVELKGKKVLVRVDFNVPIKDGVITNDNRITAALPTIKYILEQGGRAVLFSHLGRVKEEADKAGKSLAPVAKALSEKLGQDVVFPGTTRGAELEAAINELKDGEILLVENTRFEDIDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVDKAVAGFLLENEIAYIQEAVEAPERPFVAILGGSKVSDKIGVIENLLSKADKVIIGGGMAYTFLKAQGYEIGTSLVEDDKLDLAKELLEKAAGKLILPLDHKVANAFAGYTEVKETADQNIPAGFMGLDVASKTIADYNTQLEGAKTVVWNGPVGVFENTDFQAGTVGLMEAIVKQPGVKSIIGGGDSAAAAINLGYADKFSWISTGGGASMELLEGKVLPGLAALTEK
Protein: Splicing factor 45 (RNA-binding motif protein 17) (Q8SYI1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR031066}.
Interaction partners:
Sequence:
MLQTQLAVKMAVKKPLMTPVVNLRSKRLADPEVTCFAPITTVVSKPLISGKALPSILERINRGDWDVADEYDPQRPNEYEKLKEKSNGSDKNRAGVSDREDRDDKEKDRKRGRVGRREFYRDEVSAPNLKLSGFGHRQNDDDMYLPSPGLVAKQGGATIAPPPSLQEMSIDSGCEATNTMPYSASSVAAKIMAKYGFKDGQGLGKSEQGMAIALQVEKTSKRGGRIIHEKDVFLPPLALSPPSIGSQIGTSPSHKAMPPPQMVDTAAESGDIGYSITEIMKSPSKVVLLRNMVGPGDVDEELEPEVKDECNTKYGEVNSVIIHESFGTVPEDAVKIFVEFRRIESAIKAVVDLNGRFFGGRQVRAGFYNYDKFKCFQLH