wanglab/gogpt-training-data huggingface dataset:
Protein: Polyprotein of EF-Ts, chloroplastic (110 kDa pro-protein) [Cleaved into: Plastid-specific ribosomal protein-7, chloroplastic (65 kDa protein PSRP-7) (CrePSRP-7); Elongation factor Ts, chloroplastic (55 kDa protein EF-Ts) (EF-Ts)] (A8J637)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:12417713, ECO:0000269|PubMed:15548736}.
Interaction partners:
- Elongation factor Tu, chloroplastic
- Ribosome-recycling factor, chloroplastic
- Elongation factor Tu
- Uncharacterized protein
- UMP kinase
- peptidylprolyl isomerase
- 40S ribosomal protein S3
- Uncharacterized protein
- Uncharacterized protein
- Large ribosomal subunit protein uL23c
Sequence:
MLRELGRTATVKAHGRSVLRPVRGPAGRRQVAFTGVRPSVRVFAEAPAAEQAAKAIKLEDVKEGSEYEGTVTTVEEFGAFVNFGANTNGLVHISKLASGFTKNAKDVVQPGQKVTVKVLSVDAEKKRVSLELKSAVAAEASAEESDDIITEPDREGADATDDDEDVEVELEDGQVEVRADLPGFEDIPFVMEEADMDAEMSEAAIAALEADLDGAEIRYELEAPAYMEEVTGKVARIEDYGVFLEFEWNGKTLTGLLAKDEMKVPSSALSAEAQAALRAEWADTGFEMPAFVELPDDELDVKKYYQPGESVPAFVLESSLVDGRGISLTHFTDEEVSAEAVAAYEELEDDEDEELDKMMADAAGLEDEVLAFDPEALMEEDEGEEAGAAADAGDDAEYEGVSADGLEGANGNYALGATRSGLIKGKNGYQVAPMGLPSRPLNDAVTSSGLAILGTSEVDFDGDEVQLVDYWTSEAFDNIPKDVLKKLGLKMSYTEAGEAEFEERADFEATDVPFYLYGGDVESRAKEFVADLLSDDVDEAELPARAGRAPIVLAAAVQNISAAEVKALREKTGAGMMDCKKALAECAGDAEAAAEWLRKKGLSGADKKAGRIAAEGAVARYIHPGSRLGVLLEVNCETDFVAASEKFQALVNELGMIIAATDCICVSPEDVPEEVLAKEREVEMGKEDLANKPEAIRAKIVEGRLQKMRDQVALTNQATLSNPDKTVAELVKETIAAVGENVKIRRFIKYRLGEGLEKKANDFAAEVAQQTQAKAAAPAAPKKEEPKKEEPKKATVAVSAGTVKELRDKTGAGMMDCKKALAENENDMEKATEWLRMKGLAGADKKAGRIAAEGVVASYIHPGSRLGVLLEVNCETDFVAASEKFNELVNYIAMGIVAGQNVQYVSADEIPAEVFEREKQLEMARDDLKGKPDAIRAKIAEGRAKKIATEMCLLDQPFLTDPSKTVAEAIKESIAAIGEKISVRRFVKFQLGEGLEKKSNDFAAEVAAATGAK
Protein: Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein (Q388M8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Heat shock protein, mitochondrial, putative
- Heat shock protein 83
- Lipophosphoglycan biosynthetic protein, putative
- Uncharacterized protein
- CS domain-containing protein
- CS domain-containing protein
Sequence:
MARIGEGDPRWIVNDRKDGQNVNAWHWEERDLSNDCHEELKRRLNNFKLCSDDDGYNLHISEVSEISGDVTVAQRKGKMMCYFELKLTLKWSGEKEVSGKMTVPEVDHDSFRDEYDIVVTTTDNKDETQRAEAVVRAKGRAAVRGVITKYFEELFETYQIGKNLKNGSSLPPPPPQNNKSASTHEKPTTSSAGGNVSSTNFSWKMRWRIPVEELFTVLMNEQRASVYTRAPAKIDPRSGGIFDFLGGVITGFFVEVVPNSLIKMQWRLRSWPSGIHSSVVMSLEQEEQGVTLLEFAQVGIPEGELQNVKEGWRANFFDAIKMVFGYSLEYL
Protein: RAS-related (EC 3.6.5.2) (Related RAS viral (R-ras) oncogene homolog) (Rras protein) (Q4V9D8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
- Son of sevenless homolog 1
- Neurofibromin 1a.
- Son of sevenless homolog 2
- non-specific serine/threonine protein kinase
- Neurofibromin
- Raf-1 proto-oncogene, serine/threonine kinase b.
- Raf-1 proto-oncogene, serine/threonine kinase a.
- Ras association domain-containing protein 5 isoform X1
- non-specific serine/threonine protein kinase
- Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase.
Sequence:
MSTEERYKLVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICTVDGKETRLDILDTAGQEEFGAMREQYMRSGEGFLLVFALNDSGSYNEIQKFHTQILRVKDRDDFPMVLVGNKSDLDQQRVISKEEAMTFARENRIHYMESSAKNRHNVDEAFMEVVRAIRKFQETESPPLPANHTGKQKSGGCPCTLL
Protein: Killer cell immunoglobulin-like receptor 2DL1 (CD158 antigen-like family member A) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor CL-42/47.11) (p58.1 MHC class-I-specific NK receptor) (CD antigen CD158a) (P43626)
Organism: Homo sapiens (Human)
Function: Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18624290}; Single-pass type I membrane protein.
Interaction partners:
- Killer cell immunoglobulin-like receptor 2DL3
- HLA class I histocompatibility antigen, C alpha chain
- Natural killer cells antigen CD94
- Killer cell immunoglobulin-like receptor 3DL1
- Killer cell immunoglobulin-like receptor 3DL2
- Killer cell immunoglobulin-like receptor 3DL3
- NKG2-A/NKG2-B type II integral membrane protein
- NKG2-C type II integral membrane protein
- HLA class I histocompatibility antigen, B alpha chain
- HLA class I histocompatibility antigen, A alpha chain
Sequence:
MSLLVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGRLVKSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKPSLSAQLGPTVLAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP
Protein: Large ribosomal subunit protein uL5y/uL5x/uL5w (60S ribosomal protein L11-2) (L16) (P42794)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P0C0W9}. Cytoplasm {ECO:0000250|UniProtKB:P0C0W9}.
Interaction partners:
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL21x/eL21w
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein eL42z/eL42y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein uL22y
Sequence:
MASEKKLSNPMRDIKVQKLVLNISVGESGDRLTRASKVLEQLSGQTPVFSKARYTVRSFGIRRNEKIACYVTVRGEKAMQLLESGLKVKEYELLRRNFSDTGCFGFGIQEHIDLGIKYDPSTGIYGMDFYVVLERPGYRVARRRRCKTRVGIQHRVTKDDAMKWFQVKYEGVILNKSQNITG
Protein: Regulatory protein zeste (O17430)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTMANGAVNKQYSATDLEAFMKIAANWQNSNHNLLEGVDIKTEMTQYMNSPSMNMYKKRERTQNWNHQEKKYLLDLCRKDMRIIENKRLDAGLTAVKNKAWKIIHQKFSNQFGTDRTCNRLKEQWRRMKACTRNEILDYNNRLARFGAEVADRKKPSPFTFEVWDFMQEAKKACKSEALDGIDYSKIPLALEEGFEYREDYKFNPEDHDMDDSRTPPQELCDVDIKEEENNETFNETFNHHHLNQSDILGSGERLSVSPNHSISRHGIHEAESPATISTSNVLDSSGAYMAGGGDMSGFQANFNMNNISATLEALNALRSGQFPSAAAAAAAAIHQHQAQAQAQVAMHHQHNNNNNNNNNEDDEDSMKPQSKRQRTSSGSMLGSEDQAPVLAPSVPASSDSQALERSGSSNGLTMPGTAVSTNANSSSSNNNNFELRMFMEMQSKEHMMRMKILEVQLQAAKHSRDLVEINKTLALQKLQLELASKRLPS
Protein: Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (B3KWA8)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
Sequence:
MAPSRFRTQLELVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
Protein: Uncharacterized methyltransferase Rv0089 (EC 2.1.1.-) (P9WK03)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv2715
- Dethiobiotin synthetase BioD
- Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Sequence:
MDQPWNANIHYDALLDAMVPLGTQCVLDVGCGDGLLAARLARRIPYVTAVDIDAPVLRRAQTRFANAPIRWLHADIMTAELPNAGFDAVVSNAALHHIEDTRTALSRLGGLVTPGGTLAVVTFVTPSLRNGLWHLTSWVACGMANRVKGKWEHSAPIKWPPPQTLHELRSHVRALLPGACIRRLLYGRVLVTWRAPV
Protein: Proteasome subunit alpha type (B5DGU3)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Interaction partners:
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSLAIRGQDCAVVVTQKKVPDKLLDASTVTHLFKITENIGCVMSGMTADSKSQVQRARYEAANWKYKYGYEIPVDMLCKRMADISQVYTQNAEMRPLGCCMIVIGVDEECGPQVYKCDPAGYYCGFKATAAGVKQTEATTFLEKKVKKKLDWTFAQTIETAITCLSTVLSIDFKPSELEIGVITTEDPKFRILTETEIDVHLVSLSERD
Protein: N-acetylgalactosaminyltransferase 7 (EC 2.4.1.41) (Polypeptide GalNAc transferase 7) (GalNAc-T7) (pp-GaNTase 7) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7) (Q86SF2)
Organism: Homo sapiens (Human)
Function: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Polypeptide N-acetylgalactosaminyltransferase 4
- C1GALT1-specific chaperone 1
- C1GALT1-specific chaperone 1-like protein
Sequence:
MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINKAKNEQEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPIYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV
Protein: Sodium/potassium-transporting ATPase subunit gamma (Na(+)/K(+) ATPase subunit gamma) (FXYD domain-containing ion transport regulator 2) (Sodium pump gamma chain) (Q04646)
Organism: Mus musculus (Mouse)
Function: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Subcellular location: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit alpha-1
- Sodium/potassium-transporting ATPase subunit alpha-3
- Sodium/potassium-transporting ATPase subunit alpha-4
- Sodium/potassium-transporting ATPase subunit alpha-2
- Sodium/potassium-transporting ATPase subunit beta-2
- Sodium/potassium-transporting ATPase subunit beta-3
- Protein ATP1B4
- FXYD domain-containing ion transport regulator 4
- Phospholemman
Sequence:
MAGEISDLSANSGGSAKGTENPFEYDYETVRKGGLIFAGLAFVVGLLIILSKRFRCGGGKKHRQVNEDEL
Protein: Transmembrane protein 132D (Mature oligodendrocytes transmembrane protein) (Mature OL transmembrane protein) (Q76HP2)
Organism: Rattus norvegicus (Rat)
Function: May serve as a cell-surface marker for oligodendrocyte differentiation.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MCPSEMGTLWYLWSPVLISLAALFSKVTEGRGILESIQRFSLLPTYLPVTYHINNADVSFFLKEANQDIMRNSSLQSRVESFLIYKSRRLPVLNASYGPFSLEQVVPQDLMLPSNPFGFTNTFSLNWRLKAYILQEKVYLSHPKVQVLFHIVGRDWDDHRDENLPCLRVFAFRETQEVRGSCRLGGALGLCVAQLEMLPGWFSPPSVVSGRRRPTEQPEGSPVELYYAVQPGDERGDCAKEDSRKSGGAPAGHNDVDESSPPLHRIGSVFLRETPSSPPLRELRLDSNVAVHYIPKTVRQGDVLTFPISVSRNCTEDRFTLRAKVKKGVSIVGVRASTSSLWDVKQSTEYTGKYAPAVIICQKKSAGSGKSVDDASYEVMKIDIEVEAPSDPPTTQLVTWQVEYPGEITSDLGVSKIYVSQKDLIGVIPLAMEAEILNTAILTGKTVAVPVKVISVEEDGTVQGLSDSVECRSSDEDVVKVSDRCDYVFVNGKEMKGKVNVVVTVTYQHLSSPLEMTVWVPRLPLQIEVSDMELNQIKGWRVPVVSNKRPARDSEEEDDDEKRGRGCTLQYQHAMVRVLTQFVAEAPDPGGHLAHLLGSDWQVDITELITDFMQVEEPRIAKLQGGQILTGQELGMTTIQILSPLSDAILAEKTITVLDEKVTITDLGVQLVTGLSLSLQLSPGSNRAIFATAVAQELLQRPKQEAAISCWVQFSDGSVTPLDIYDEKDFSLMATSLDEKVVSILQDPKFKWPIIAAENEGQGALVKVEMLISESCQKSKRKSVLAVGTASIKVKFGQNDANPNGSESGHLGAGLHVENINDRRSKKPFQEWGSPEGPYYSSSSMGLMEGWGSTTKRPTFPKKEGQENLLDDIILSQTMATDLTSFPDQVDLPGSNVGTEEHDPDQAAKGLSDLEIGMYALLGVFCLAILVFLINCVTFALKYRHKQVPFEEQEGLSHSHDWVGLSNRTELLGNHMNFASSQEEQITAIDRGLDFEESKLLLSSNSQNSINGQLFRSTGAMLTDDKEQKSEPPTSPTSKRKRVTFSTFSAISSDDGCPSGNTMVLSNEDDIKWVCQALDPGECPEPHSCMERLHEHV
Protein: Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) (P26639)
Organism: Homo sapiens (Human)
Function: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9D0R2}.
Interaction partners:
- Leucine--tRNA ligase, cytoplasmic
- Leucine--tRNA ligase, mitochondrial
- Threonine--tRNA ligase 2, cytoplasmic
- Eukaryotic translation initiation factor 4E type 2
- Alanine--tRNA ligase, cytoplasmic
- Bifunctional glutamate/proline--tRNA ligase
- Asparagine--tRNA ligase, cytoplasmic
- Serine--tRNA ligase, cytoplasmic
- Isoleucine--tRNA ligase, cytoplasmic
- Tyrosine--tRNA ligase, cytoplasmic
Sequence:
MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEMYNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIAKVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGISFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEF
Protein: Complexin-1 (Complexin I) (CPX I) (Synaphin-2) (O14810)
Organism: Homo sapiens (Human)
Function: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P63040}. Perikaryon {ECO:0000250|UniProtKB:P63040}. Presynapse {ECO:0000250|UniProtKB:P63040}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250|UniProtKB:P63040}.
Interaction partners:
- Synaptotagmin-1
- Synaptosomal-associated protein 25
- Syntaxin-1A
- Vesicle-associated membrane protein 2
- Vesicle-associated membrane protein 3
- Complexin-3
- Complexin-4
- V-SNARE coiled-coil homology domain-containing protein
- Complexin-2
- Syntaxin-binding protein 1
Sequence:
MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK
Protein: Hisactophilin-1 (Histidine-rich actin-binding protein 1) (HS I) (P13231)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May act as an intracellular pH sensor that links chemotactic signals to responses in the microfilament system of the cells by nucleating actin polymerization or stabilizing the filaments.
Subcellular location: Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side.
Interaction partners:
Sequence:
MGNRAFKSHHGHFLSAEGEAVKTHHGHHDHHTHFHVENHGGKVALKTHCGKYLSIGDHKQVYLSHHLHGDHSLFHLEHHGGKVSIKGHHHHYISADHHGHVSTKEHHDHDTTFEEIII
Protein: Hemomucin (Q58SN2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
VTPPKDLKGALESNFHLEGAERLLEGRVYGPECLIARNNEIYTGIHGGEVIKLTSNHVTHVTKIGQPCEDIYEESRCGRPLGLAFDTQGNNLIIADAYYGLWQVDLGTNKKTLLVSPAQELAGKSINRPAKIFNGVTVSKEGDVYWTDSSSDFTIEDLVFASFANPSGRLFKYNRSKNVSEVLLDELAFANGLALSPNEDFIVVAETGAMRLTKYHLKGAKAGQSEVFVDGLPGLPDNLTPDAEGIWVPLVQSADSEHPNGFTLFTRFPSVRLFLARMLALFELPFRYLNSVYPNKFSQRFIHFVGHMESITVLAPKRTTVVRVDWNGNIVGSLHGFDKSAATVSHVLEFQDFLFLGSPTNQYLARVKSPKAKQPTLKVRNVRVEGEGLEASIGVPPSKATPKPKAAPSTTTPKPTTTTTTTTPKPTTKTTTTTTTPKPTTTTTTKKPTTTTTTTTTTPKPTTTKPPTAKPSTTTTTTTTPKPTTTTTPTTPTPEPSKPKVKRTVPEKPAPVEEDIPSD
Protein: RNA helicase (EC 3.6.4.13) (Q8MZ98)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWARFKNRFSLFYANLKSPTTRPVGQSVVFAKPTDLENIWKLCDFYMKHKLPRPGHLLGILSQRRLEEQPTSRSLCHQMAAFGDCLRHKCMYRHVMWRDEVLPPDHYPKNGLIRFLVLVCYSPAALAVRLSDQFPTAIRFLNFPMSDLGERVQRHYELEANRHMHPNPVPGEMAVVKNINRYERVHIVSVESNAMVLVQLLDTSTECFSYKTSQLYSCDKIFKVWPYMMIDDSSMDSLQTVVHCHRIHPEKRWI
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) (P21568)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P14832}.
Interaction partners:
- Uncharacterized protein
- Actinidain
- Elongation factor 1-alpha
- Glyceraldehyde-3-phosphate dehydrogenase
- Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein
- Peptidase C1A papain C-terminal domain-containing protein
- Granulins domain-containing protein
- Low-temperature-induced cysteine proteinase-like
- Cysteine protease
- Peptidase C1A papain C-terminal domain-containing protein
Sequence:
MANPKVFFDLTIGGAPAGRVVMELFADTTPKTAENFRALCTGEKGVGKMGKPLHYKGSTFHRVIPGFMCQGGDFTAGNGTGGESIYGAKFNDENFVKKHTGPGILSMANAGPGTNGSQFFICTAKTEWLNGKHVVFGQVVEGMDVIKKAEAVGSSSGRCSKPVVIADCGQL
Protein: A disintegrin and metallopeptidase domain 30 (ADAM30) (Q811Q3)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Disintegrin and metalloproteinase domain-containing protein 2
- Disintegrin and metalloproteinase domain-containing protein 25
- Disintegrin and metalloproteinase domain-containing protein 21
Sequence:
MRSVWAFLPQHRWLFLTMLFHEAVGEEDLLFDPDWGFDSYEITIPKVISFKKGAQGVDSSLSYLLQIEGKARVVHLRPKKLLLPRHLPVFSFTQEGSLIEDYPHIPDQCNYVGSVEGSQESESTLSTCMGGLRGVLNIDSRYYQIEPLRASSSFEHVVYLVTEDNFNNETCGVVDEETGGQTAEEEEMARISSFHQSYKHQRYLELVMVFDLDRFVFARGNMSRMVDDAILLASIADTYFQDVSLKIQLKALEVWTYYNRIRLYYPSLSEVLGQFVHYKRNSMHHRLPADWFHLYIARRYIDANAWSWGRACEEFHAGSASSFLNVNILGPATWTAHELGHCVGMIHDEEFCQCRGRKSCIMGTGRTGFSNCSYHQYFLHASYKMSYCLSDFPKLHIVERCGNKIVENKEECDCGSKEDCKKDLCCGPDCKWKEGVNCSSGLCCHKCNFLPSGYVCRKEVNECDLEEYCDGTSGVCPDDSYKQDGTPCRNGGFCFRKGCRSRYLQCQSIFGRKAKEAPHQCYEAVNMLGDQSGNCGIVNATRYTRCHRGNTICGRLQCINVKALSKFPDHTIILSTYLRGDNLICWGTSYHGTMIPHGVPDIGDISDGTSCGRNRVCLNRTCVDYTNLKFDCLPDKCNSRGVCNNRKNCHCSYGWEPPFCVEVGYGGSLDSGPPGPRIEVLSTTSALYMLRTILFLVSMIVVCLGQLIRNLFRNRRRNLQQKNPAETQGKKR
Protein: Gal102p (Q59VY4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Galactose-1-phosphate uridylyltransferase
- Mannose-1-phosphate guanyltransferase
- Galactokinase
- Bifunctional protein GAL10
Sequence:
MTVSFDKRIVVSGGAGFIGIHFLCYMVKKYPNFHFTCIDKLNYASNATEIENLKSFSNFEFVHLDLSDNLEYLLKITKNTTDIINFAAESSVDRSFKDPVYFTKNNILATQNLLECHRLNPSIGYFLHISTDEVYGDVYEGDNKENAVMNPTNPYSASKAAIDLIIKSYQYSYKLPITILRPNNVYGPLQYPEKIIPLTIQCINEKKPIPVHGKGTNKRKYLYVLDIVLAIETVWIKNPMTTVNQIYNIGGTDELDNLSLIKLIMEIFGRGEIQFIKDRNYNDTNYSIDTTKIHNLGWSPKISLVQGLQLCKQSLDSPIE
Protein: Small ribosomal subunit protein uS12y (40S ribosomal protein S23-2) (S12) (P49201)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein eS7z
- Large ribosomal subunit protein eL32z
- Small ribosomal subunit protein eS7y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS9x
- Large ribosomal subunit protein uL22y
- Small ribosomal subunit protein uS10y
- Small ribosomal subunit protein eS19z
- Small ribosomal subunit protein eS6y
Sequence:
MGKTRGMGAGRKLKRLRINQRWADKQYKKSHLGNEWKKPFAGSSHAKGIVLEKIGIEAKQPNSAIRKCARVQLIKNGKKIAAFVPNDGCLNYIEENDEVLIAGFGRKGHAVGDIPGVRFKVVKVSGVSLLALFKEKKEKPRS
Protein: RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (C1PIG3)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MNDVAVVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDLEQRESPLNNFSVAQCRLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEEMMDFRSGSPSENSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFPEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLSPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFASIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMEGVDSERRPHFPQFSYSASGTA
Protein: LIM/homeobox protein Lhx9 (LIM homeobox protein 9) (Q9WUH2)
Organism: Mus musculus (Mouse)
Function: Involved in gonadal development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10706291}.
Interaction partners:
- LIM/homeobox protein Lhx2
- LIM domain-binding protein 1
- LIM domain-binding protein 2
Sequence:
MEIVGCRAENNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLTKGTQLNGRDAGMPPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSLVYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIVNYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALTPPGTATTLTDLTNPTVTVVTTVTSNMDSHEPGSPSQTTLTNLF