wanglab/gogpt-training-data huggingface dataset:
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (S5RNB2)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MMSRSGRFKSTRTGSSTGQCEPPQGPGVHVYLFWTKGGERYLTHTEGKVTAEELSISAAQTVGITPLCHVLFSLYDPESHCWYSPNHFFNSEEQTRLTLHYRMRFYFRNWHGLSEKEPSVVRYAPRSGTEHGGSPLLEMTSLEYLFCQAKFDFVNDVTPMEDAQGKEELSRFKNESLGMAVLHLSHQALRSGCTLQEVAKSVSFLRCIPRSFAKHIARDNFLTKIRIRRVFADFVRTFQEHTVDVGRLGSQEVMYKYLSTLEHLAPRFGTETFLAAHLELRTDGGDGSGSYLNTSRAHGASDPENVGPQVMHEVMVSGTKGIQWRKMTVQKPQANSYFGNDYLGNRKSVKQSPLQQEPTSSDTWTSFCDFPEISHITITGANVSIIKQDNFSMEVQMNSSLEALSFVSLLDGYFRLTADAHHYLCHEVAPPRVVLSATNGLHGPMKLRKEAVEEGAFLVRWSVLDYHRIILAVLNKSQNGQAAIHKQFRILHSGSVFALEGWDREFSSVKELTDSLKAFVLKSGTDNFTVKKCCLPRPAELSNLLVMRQGVDQCVQPDSVALCLTQLKFHQIKDKEITQEQHLGRGTRTNIYSGRLLVWGGAEEDEEDKWNNNLTDRKEIRVVLKILDQSHKDIALAFFETASLMSQVSHSHLVFVHGVSVKGSENIMVEEFVEFGPLDVFLRRERALVTPQWKFTVAKQLASALSYLETKQLVHGNVCGKNILVARRGLEEGTFPFVKLSDPGIALNVLSREERVERIPWIAPECVPSSAPFGRAADQWSFGATLLEICNNGDLPMSGSTLTEKERFYETRSRLTEPSSQELASFISMCLTYEPRERPSFRTVLRELTELQLKNPDISPLESLPDADPNVFLKRYLKKIRDLGEGHFGKVMLYVYDPANDGTGDYVAVKALKHEGGSHLHEGWMKEIEILKSLYHSNIVKYKGCCSELGGQTVQLIMEFLPLGSLREYLVKHRLGVAHSLLFAQQICQGMDYLHSKRYIHRDLAARNVLVENEHLVKIGDFGLTKYIPEGDVYYRVREDGDSPVYWYAIECLKESKFSFSSDIWSFGVTLYEVLTHGDHRQSPPVKFTQMMGNVHGQMTVMVLVKLLEKHNRLPCPRDCPSEVHMLMQHCWDFDPARRPSFKSLIESIGAICKTYERQPNMRLAQISQ
Protein: Flagellar protein FliT (P39740)
Organism: Bacillus subtilis (strain 168)
Function: May act as an export chaperone for the filament capping protein FliD.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Flagellar secretion chaperone FliS
- Flagellar hook-associated protein 2
- Uncharacterized protein YvyC
- Uncharacterized protein YvzG
- Flagellar FliJ protein
- Negative regulator of flagellin synthesis
- Flagellin
- Flagellar hook-associated protein 3
- Methyl-accepting chemotaxis protein McpB
- Flagellar biosynthetic protein FliZ
Sequence:
MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQEISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNITIDGTYYDKRK
Protein: UV excision repair protein RAD23 (A0A1D8PGE3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU367049}. Cytoplasm {ECO:0000256|RuleBase:RU367049}.
Interaction partners:
- Peptide-N
- DNA repair protein RAD4
- Proteasome regulatory particle base subunit
- Elongation factor 3
- Elf1p
- Polyubiquitin
- RING-type E3 ubiquitin transferase
- DNA repair protein RAD14
- 26S proteasome regulatory subunit RPN1
- Uncharacterized protein
Sequence:
MQIIFKDFKKQTVSLDVELTDTVLSTKEKLAQEKSCESSQIKLVYSGKVLQDDKDLQSYKLKEGASIIFMINKTKKTPTPVPETKSTTGTSNVENKSTTESSTQNKAQGSTNESTTTTSSSSAPAPAPAGATTTTSEQQQPQPAASNESTFAVGSEREASIQNIMEMGYERPQVEAALRAAFNNPHRAVEYLLTGIPESLQHPVAPAQPPATGTAPAQQTEGNTSESGQQGEDEEHEGDESTQHENLFEAAAAAAGAGAGGAGSGAGAGAGSAEGDIGGLGDDQQMQLLRAALQSNPELIQPLLEQLAASNPQIANLIQQDPEAFIRMFLSGAPGSGNDLGFEFEDESGETGAGGAAAAATGEDEQGTIRIQLSEQDNNAINRLCELGFERDIVIQVYLACDKNEEVAADILFRDM
Protein: Rho-related GTP-binding protein RhoB (P62746)
Organism: Mus musculus (Mouse)
Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:14597666}; Lipid-anchor {ECO:0000269|PubMed:14597666}. Cell membrane {ECO:0000269|PubMed:14597666}; Lipid-anchor {ECO:0000269|PubMed:14597666}. Nucleus {ECO:0000269|PubMed:14597666}. Cleavage furrow {ECO:0000250}. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner (By similarity). Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. {ECO:0000250}.
Interaction partners:
- Rho GDP-dissociation inhibitor 3
- Rho-associated protein kinase 2
- Rho-associated protein kinase 1
- Rho-related GTP-binding protein RhoH
- Protein diaphanous homolog 3
- Serine/threonine-protein kinase N1
- Intersectin-1
- Rhotekin
- Rho GDP-dissociation inhibitor 1
- Rho guanine nucleotide exchange factor 3
Sequence:
MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL
Protein: Neuferricin (Cytochrome b5 domain-containing protein 2) (Q8WUJ1)
Organism: Homo sapiens (Human)
Function: Heme-binding protein which promotes neuronal but not astrocyte differentiation.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Cytochrome b5
Sequence:
MLRCGGRGLLLGLAVAAAAVMAARLMGWWGPRAGFRLFIPEELSRYRGGPGDPGLYLALLGRVYDVSSGRRHYEPGSHYSGFAGRDASRAFVTGDCSEAGLVDDVSDLSAAEMLTLHNWLSFYEKNYVCVGRVTGRFYGEDGLPTPALTQVEAAITRGLEANKLQLQEKQTFPPCNAEWSSARGSRLWCSQKSGGVSRDWIGVPRKLYKPGAKEPRCVCVRTTGPPSGQMPDNPPHRNRGDLDHPNLAEYTGCPPLAITCSFPL
Protein: Translation initiation factor eIF2B subunit beta (eIF2B GDP-GTP exchange factor subunit beta) (Q9UT76)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit gamma
- Translation initiation factor eIF2B subunit epsilon
- Translation initiation factor eIF2B subunit delta
- Eukaryotic translation initiation factor 2 subunit alpha
- Eukaryotic translation initiation factor 2 subunit gamma
- Probable eukaryotic translation initiation factor 2 subunit beta
- Vacuolar protein sorting-associated protein 9b
- Acetyl-CoA hydrolase
- Vacuolar protein sorting-associated protein vps901
Sequence:
MSTINVEHTYPAVSSLIADLKSRKVQGPFAVAVETALVMRQVISQTRWSTVDQLIDTVRAVGSTLVKAQPTEFSCGNIIRRILRLIREEYQELLKTADENEKLIVSSSNSSSPSQKRDIPSNEKLVQSHEPVSVQMYSSMLNLLGRPTLESPTHSKTVGDSRVTGGMDMRAVIISGIQDVIDELDKINTDIEVQSMDHLHSNEIILTQGCSKTVEAFLRFAAKKRKFSVIVAEGFPNNQKGSHAMAKRLAQAGIDTTVISDATIFAIMSRVNKVILGTHAILGNGGLVTYSGAQLVAQAARHHATPVVVCSGIYKLSPVYPYDLESIIQLSSPDKIMSFNEGDLISRAEILNPYYDYIPPDLVDLFITNLGGYPPSYLYRIMNDTYDASDTIL
Protein: ER lumen protein-retaining receptor 1 (KDEL endoplasmic reticulum protein retention receptor 1) (KDEL receptor 1) (Q569A6)
Organism: Rattus norvegicus (Rat)
Function: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:P33946}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250|UniProtKB:P33946}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P33946}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:P33946}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. {ECO:0000250|UniProtKB:P33946}.
Interaction partners:
- Coatomer subunit beta
- Gamma-soluble NSF attachment protein
- Synaptobrevin homolog YKT6
- Coatomer subunit gamma-1
- Coatomer subunit delta
Sequence:
MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVFTARYLDLFTNYISLYNTCMKVVYIACSFTTVWMIYSKFKATYDGNHDTFRVEFLVVPTAVLAFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSKTGEAETITSHYLFALGVYRTLYLFNWIWRYHFEGFFDLIAIVAGLVQTVLYCDFFYLYITKVLKGKKLSLPA
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0G2K490)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Ras-related protein Rap-2
- Striatin-4
- NCK adaptor protein 1.
- Catenin beta-1
- Disrupted in schizophrenia 1 homolog
Sequence:
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHGQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPLEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPQLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPVLESSLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPSKVKPEESRDIPRPSRPASYKKAIDEDLTALAKELRELRIEETNRPLKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGKNEQYNMGMVGTHGLETSHADTFGGSISREGTLMIRETAEEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDTGAEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDDESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Protein: AT-rich interactive domain-containing protein cfi-1 (ARID domain-containing protein CFI-1) (O02326)
Organism: Caenorhabditis elegans
Function: Transcription factor. Regulates neuronal subtype identity. Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons. Probably acts by binding to specific promoter elements. Promotes differentiation of URA sensory neurons and prevents them from expressing male-specific CEM neuronal features. Promotes differentiation of AVD and PVC interneurons and their glutamate receptor expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:11959845}.
Interaction partners:
- Transcription factor unc-3
- Transcription factor unc-86
- Homeobox protein unc-42
- GLutamate Receptor family
Sequence:
MSVRIDEPQLFVSMSKEPTQETVNVGGHHDDSSSNCDERVDDQTEEQKSPPASPDLTANLNVFDLESRQKVVQRLLNSQLNLSNLRAPLNLPPIFQALQGPFSIQQQLLGLASGLTAISPGLDDYDEENTNQGEPEDLTLGGFRKETSVKSEEPSESGINASGPAWSYEEQFKQLYELSDDVKRKEWLDDWLNFMHRIGKPVTRIPIMAKQVLDLYELYRLVVQHGGLVEIINKKLWREITKGLNLPSSITSAAFTLRTQYQKYLYDYECEKEKLSNQSDLQQAIDGNRREAPGRRTAPSFPLPFQLPHAASAAATMLNNQLNGLGMRNDLLDDENTLSLQASGLFGTSYGAEQMAILEAHQRNLERAQRAVQQQVARQSLGLTACSNGNGGNIHNSGRESTSSNDSDIPAKRPKLENDVKTNGASSMRISTKHSDNSKTSMSVSMEINGITYQGVLFALDETVSES
Protein: Cellobiose dehydrogenase (Q7RXM0)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Interaction partners:
- Glucanase
Sequence:
MRTTSAFLSGLAAVASLLSPAFAQTAPKTFTHPDTGIVFNTWSASDSQTKGGFTVGMALPSNALTTDATEFIGYLECSSAKNGANSGWCGVSLRGAMTNNLLITAWPSDGEVYTNLMFATGYAMPKNYAGDAKITQIASSVNATHFTLVFRCQNCLSWDQDGVTGGISTSNKGAQLGWVQAFPSPGNPTCPTQITLSQHDNGMGQWGAAFDSNIANPSYTAWAAKATKTVTGTCSGPVTTSIAATPVPTGVSFDYIVVGGGAGGIPVADKLSESGKSVLLIEKGFASTGEHGGTLKPEWLNNTSLTRFDVPGLCNQIWKDSDGIACSDTDQMAGCVLGGGTAINAGLWYKPYTKDWDYLFPSGWKGSDIAGATSRALSRIPGTTTPSQDGKRYLQQGFEVLANGLKASGWKEVDSLKDSEQKNRTFSHTSYMYINGERGGPLATYLVSAKKRSNFKLWLNTAVKRVIREGGHITGVEVEAFRNGGYSGIIPVTNTTGRVVLSAGTFGSAKILLRSGIGPKDQLEVVKASADGPTMVSNSSWIDLPVGHNLVDHTNTDTVIQHNNVTFYDFYKAWDNPNTTDMNLYLNGRSGIFAQAAPNIGPLFWEEITGADGIVRQLHWTARVEGSFETPDGYAMTMSQYLGRGATSRGRMTLSPTLNTVVSDLPYLKDPNDKAAVVQGIVNLQKALANVKGLTWAYPSANQTAADFVDKQPVTYQSRRSNHWMGTNKMGTDDGRSGGTAVVDTNTRVYGTDNLYVVDASIFPGVPTTNPTAYIVVAAEHAAAKILAQPANEAVPKWGWCGGPTYTGSQTCQAPYKCEKQNDWYWQCV
Protein: Prolactin receptor (PRL-R) (P16471)
Organism: Homo sapiens (Human)
Function: This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Subcellular location: Membrane {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}; Single-pass type I membrane protein {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted.
Interaction partners:
- Prolactin
- Tyrosine-protein kinase JAK2
- Somatotropin
- Chorionic somatomammotropin hormone 1
- Chorionic somatomammotropin hormone 2
- Cytokine-inducible SH2-containing protein
- Signal transducer and activator of transcription 5B
- Signal transducer and activator of transcription 5A
- Somatotropin
- Erythropoietin
Sequence:
MKENVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQPSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVESFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKVSGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSSKCRLQLGGLDYLDPACFTHSFH
Protein: Glucan 1,3-beta-glucosidase 3 (EC 3.2.1.58) (Exo-1,3-beta-glucanase 3) (O74799)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Glucan 1,3-beta-glucosidase 2
- Cell fusion protein fus1
- Ascus wall glucan endo-1,3-beta-D-glucosidase
- Myosin-52
Sequence:
MGLNKQDLYIYRKQYGVNLGAWFCAERWINDFLFTGEGSSELEAVSGNVKAHGIDKARENFEAHWKSWIGIEDFSYMKQHLVNSVRIPLGYWSLGNDELVKGTPFEPYAEVYRNSLHILCEKIQEAGSLSIGVLLDFHGVYGGGNCDGHSGTSSGKAEFYEKQEYQDRTVEAVKFLSSKIGQFENVIGIQVINEPIWGQYDVLANFYQKARSVVPSYLPVYIGDGWDKDHWVNWVNDHESEGFYVVDHHSYFCFGGELCHAPPKLITRRLDTGEEYGKTKLSNIVIGEWSCTLSQESWSQTKLHDKRRRDFGEAQLNQYLNYCGGCFFWTYKFLHGKGGDWDFRSVVEDKVINYPPPPPTENKAMPALLEQSRDQNFGGHCYYWDQKQHDHPYEHDLYVKGWNQAWEDYIEFLQHGAMIGFPRAWTQKRMTSISSASAWEYRDGMNAAWLHLERMGFLNPFRHP
Protein: Variant surface glycoprotein (VSG), putative (Q583L6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MQSSQWLQPLVLFVMTLLLATGLKRVDAATGVGIKKTTWEPLCQVSEELDGIEGHVLQEATEMIAATIDFDAAAKRARIFSLKNPKHKWTKAAITIAAAYEAKAATAVRQLKDTYIKQQVEAASRSAYVKGLVDDFLKLLEQTVDGSNNACLLADENADTPVTRSATTKLGQTECKLTQSPITATRRTPTHITTAGYINLVEGTGGNKHQPTAATKECHLTTAHNSKGFAKSGGTDAAVTVMAGYLTIPNTAGELATANKANLIKTTSDGLKHWAEAHAAIKLVDRTLPTEYANESGDLTERAALKEAAQNLFGEAKDHQGSDEKKAIETVFSNTNVDTINTIITLIEKEDIPKGAAMRQTPTKLEDIKNSIELTNLLSYYQQRLSQDFATLDKRLEESTKHQDLKATEKICGEAKDDEDKCKGLKDKGCSFNTDTKKCELKKEVKEKLEKSNQETEGNDGKTTNTTGSNSIFIHKSPLLLVVLLLK
Protein: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (Ferredoxin), putative (EC 1.17.7.1) (Q8IJH7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, apicoplast
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, apicoplast
- 4-hydroxybenzoate polyprenyltransferase, putative
- rRNA biogenesis protein RRP5, putative
- RNA-binding protein, putative
- Iron-sulfur cluster assembly protein IscU
- 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative
Sequence:
MSYIKRLILFMLLFYSHVKIKKLFIKISNVNIFFAEAKKNGKKEFFLFLLNIKKNSQQKKTYHITKRNTINKSDFLYSLLNEEGNSSKKEYKNLKDEEKYNIIQNIKKYCECTKKYKRLPTREVVIGNVKIGGNNKIAIQTMASCDTRNVEECVYQIRKCKDLGADIVRLTVQGVQEAQASYHIKEKLLSENVNIPLVADIHFNPKIALMAADVFEKIRVNPGNYVDGRKKWIDKVYKTKEEFDEGKLFIKEKFVPLIEKCKRLNRAIRIGTNHGSLSSRVLSYYGDTPLGMVESAFEFSDLCIENNFYNLVFSMKASNAYVMIQSYRLLVSKQYERNMMFPIHLGVTEAGFGDNGRIKSYLGIGSLLYDGIGDTIRISLTEDPWEELTPCKKLVENLKKRIFYNENFKEDNELKNNEMDTKNLLNFEENYRNFNNIKKRNVEKNNNVLHEECTIGNVVTIKELEDSLQIFKDLNLEVDSNGNLKKGAKTTDMVIINDFHNITNLGKKTVDKLMQVGINIVVQYEPHNIEFIEKMEPNNDNNNNNNNNNILFYVDIKNIMNSSEKNIKLSNSKGYGLILNGKEDIQTIKKIKELNRRPLFILLKSDNIYEHVLITRRINELLQSLNINIPYIHYVDINSNNYDDILVNSTLYAGSCLMDLMGDGLIVNVTNDVLTNKKKIETKYDEKEEVEEEGNNKDIHRLLSRVALNSFLTLNILQDTRIRLFKTDYIACPSCGRTLFNIQETTKKIMKLTGHLKGVKIAVMGCIVNGIGEMADAHFGYVGSAPKKIDLYYGKELVERNIPEEEACDKLIELIKKHNKWKDP
Protein: Homeobox protein cut-like (A7DTF5)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein kup-1
- RING-Gid-type domain-containing protein
Sequence:
MSSVELPQVMDDNLISRRKKIMQSIEDIRGKKAEIAQALRELGVGKPQENESVKEDMKLLLAAFDSISAQEAQYMDILKTIVGIHEQATLDIAKDFEKKIEDDAQKLKEQKEKQEEDATEEDENAEKTPEEQANSEVIAELQEALLELKQVSEAAVAASELNEKLVERLQLTKRKKSAMMEVRAKKAKDLDDVATKVRAEVMERINKMAALKKTTTKQEKELKELQKQCLQLGLQLGTDENREIDPAAEEALLDDNQRVPVIVETQEKPDLNDEEKEKRREEIRENIKKEMEKKEQVNTLIREKLASMNARRKRLQEIRKMLEKQEHEKEKLDAAISNSAVAVQNDGEGIALTPETPRPSQEDEAEAPAAAETTVVSAPVAASEDIDEEEDGEVTEKSLDDILENARANLSNLTAMRERLEHIKETGGADLNEDDLTLLERLDNVALEEDEKLKLPPAAAPSLNEDSVDDEDEESDIESAVRATFHHVIQQPKPLELDDRQKEILNQARRAAIEDLIREIDKKLPTSPRADDSPTGSLSISLLSLEAGELREMAGYLLRLAELREQTPTP
Protein: GTPase-GDP dissociation stimulator vimar (A1Z6S7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (By similarity). May also chaperone the processing and/or trafficking of small GTPases independently of GEF activity (By similarity). By interacting with Miro, promotes mitochondrial fission in response to high calcium concentrations.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:27716788}. Mitochondrion {ECO:0000269|PubMed:27716788}. Cytoplasm, cytosol {ECO:0000269|PubMed:27716788}.
Interaction partners:
- Mitochondrial Rho GTPase
- Ras-like GTP-binding protein Rho1
Sequence:
MATAEIDDLIEKLKTTSVSPANTTNLLCEISATKDPKLFDKHELAECFLGLTKCDDTNVRKEAAKCIAEITKSEVQRKKFTKRNIIAAFLECLRQVPTSDGSMELPIQICRALGNICYLNDEARDLILELEGDAVLLRLLDITTIEDVANAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMKKLQGIIDIGASNVEQHEDLLLNTLPLLSILTENVSDLNFDSSLNIQLSRILAASTNPDLAEMCLELLHYQAESDEVKLILAKDGLCETIYNLLEKYKTLASTSEARALMKLACELIVLILTGDDSMHYLYTTPLLKNMVDWLDSTDIDLLTTGVLALGNFARTDSHCIYFVEQQTMNKLLEVLAKNNGVKDDVRLQHALLSALRNLVIPKPNKNAVIQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQEKLALELLKNKTLIEQLVHWSKSSDYAGVTGESLRLMAWLIKHAYLSKIAYALPRKGDAPAEQIADKIPLTQDYDRSSLSEFLANEGTVEAMVSMLTAQHLVMQNEALIALCILSVVYLSQPSEAAQAQLLQDELVKCEVGKKLAELISKSSDTMTKEIVENLQNCVNLLKSSEQLVAHLEQHNINELLKSIPILTEYCTL
Protein: Glutaredoxin, putative (Q4GZ42)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribonucleoside-diphosphate reductase
- peptide-methionine
Sequence:
MNNALDPAKAPQFLDMMLRRNKMVMVSATYCQFCTKLKMLLIELKHRFVSLEIDIIPNGREVFAEVVGRTGVHTVPQVFLNGKYFGGYDELVAMYRAGHLSAEIERG
Protein: Synaptobrevin homolog YKT6 (EC 2.3.1.-) (P36015)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Golgi SNAP receptor complex member 1
- Protein transport protein SFT1
- Integral membrane protein SED5
- Protein transport protein SEC22
- Syntaxin PEP12
- Vacuolar morphogenesis protein 7
- t-SNARE affecting a late Golgi compartment protein 1
- t-SNARE affecting a late Golgi compartment protein 2
- t-SNARE VTI1
- Protein transport protein BOS1
Sequence:
MRIYYIGVFRSGGEKALELSEVKDLSQFGFFERSSVGQFMTFFAETVASRTGAGQRQSIEEGNYIGHVYARSEGICGVLITDKEYPVRPAYTLLNKILDEYLVAHPKEEWADVTETNDALKMKQLDTYISKYQDPSQADAIMKVQQELDETKIVLHKTIENVLQRGEKLDNLVDKSESLTASSKMFYKQAKKSNSCCIIM
Protein: MG7 (I1VZI8)
Organism: Spodoptera litura (Asian cotton leafworm)
Interaction partners:
Sequence:
MTAKLLVLLVVVAALAEAQVTQITLPDENRNHISNPLIGFGISIPKFWFDILQSCHVIYPNGFTYEVYPNNNLPAGPISFTPAVQPFTACGVGFLHPPESFSGVYELMSLVNHTDASFTLTRQRFNIVITMSELWQADDDQKN
Protein: Neutral ceramidase A (N-CDase A) (NCDase A) (EC 3.5.1.23) (Acylsphingosine deacylase 2A) (N-acylsphingosine amidohydrolase 2A) (Q54BK2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 3.0. Has no activity toward glycosphingolipids, such as GalCer and Galbeta1-3GalNAcbeta1-4(NeuAcalpha2-3)Galbeta1-4Glcbeta1-1'Cer or sphingomyelin.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Sphingosine kinase B
- Sphingosine kinase A
- Probable sphingosine-1-phosphate phosphatase
- 3-ketodihydrosphingosine reductase
- sphingolipid 4-desaturase
- Glucosylceramidase
- Putative alkaline ceramidase dcd3A
- Putative alkaline ceramidase dcd3B
- Sphingomyelin phosphodiesterase A
- Sphingomyelin phosphodiesterase B
Sequence:
MKRSIVFIYSLVILLLSVGFIDAFKISIENHIKLSDDSSYQIGTGIYDITGPGAETNMMGYAMPGQITGGIHFRQRARAFVFIDSEGNRAVYVSTDSCMIFQEVKIQVIQDLQEIFGPTLYTHDNVLLSGTHTHSGPAGFSEYALYGITALGFYKKNFDTICDGIVQAIVKAHKSVQPARMLTQQGELWNSNINRSPYAYDNNPEEEKAMYDANVDKNMTVIRIEDMSGNPFAAISFFGVHCTSMNNTNHLISGDNKGYASYLWEKHANGQSSLPGTGPFIAAFGQSNEGDVSPNTRGPTCRDGKPCDYKTSTCNGKVEECWALGPGTDGDMFESTQIIGGNQFNKALELFNNATIQVSGKIQYRHTWKPFTNVSVEAPYNSGVEGATTCRGAMGYSFAGGTTDGPGAFNFIQGDNSTTNPFWNFIGGIIAKPTPQQTACQAPKPILIDVGMVEPIPWVPDVMPLQIITLGQIVLVAVPGEFTTMSGRRLRNTVREIIGQSIENPIVLIAGLANTYSGYIATFEEFQVQRYEGASTVFGPHTLGAYQQEFANLAQSIVDGSQADPGTFPRNMSGHTPFFLPPVIVDVAPKFDDFGDIYTDVSTTTPYSINQTVTVIFYGANLRNNFMTESSFLTVDQLQSNGQWTTILNDGDWDTKLYWKMHDLGFSLITVDWTISPITQPGTYRITHSGYAKKNPFSDNLTFYQGISSNFNVQ
Protein: GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (PH domain-containing adaptor molecule p97) (Q9Z1S8)
Organism: Mus musculus (Mouse)
Function: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UQC2}. Cell membrane {ECO:0000250|UniProtKB:Q9UQC2}. Membrane raft {ECO:0000269|PubMed:23478294}.
Interaction partners:
- Growth factor receptor-bound protein 2
- Tyrosine-protein phosphatase non-receptor type 11
- SHC-transforming protein 1
- Tyrosine-protein kinase Lyn
- Tyrosine-protein kinase Fyn
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Tyrosine-protein kinase SYK
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Sequence:
MSGGGGDDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNEHSKKPLRIINLNLCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEADMNKWVQSICQICGFNQAEESTDSLRNLSSASHGPRSSPAEFSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSSHMQPTLSTSAPQEYLYLHQCISRRTENARSASFSQGTRQKSDTAVQKLAQSNGHCINGVGGQVHGFYSLPKPSRHNTEFKDSTYDLPRSLASHGHTKSSLTGSETDNEDVYTFKMPSNTLCRELGDLLVDNMDVPTTPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETSQWGSIQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPARGSGESASWSAEPPGKTAVGRSNSASSDDNYVPMNPGSSTLLAMERPGDNSQSVYIPMSPGPHHFDPLGYPSTALPIHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPVTKSWSRINHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPGSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL