wanglab/gogpt-training-data huggingface dataset:
Protein: Chaperone Ric-8A (Synembryn-A) (Q3TIR3)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:22114146}. Cytoplasm {ECO:0000250|UniProtKB:Q80ZG1}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide exchange factor MSS4
Sequence:
MEPRAVADALETGEEDAVTEALRSFNREHSQSFTFDDAQQEDRKRLAKLLVSVLEQGLSPKHRVTWLQTIRILSRDRSCLDSFASRQSLHALACYADITVSEEPIPQSPDMDVLLESLKCLCNLVLSSPTAQMLAAEARLVVRLAERVGLYRKRSYPHEVQFFDLRLLFLLTALRTDVRQQLFQELHGVRLLTDALELTLGVAPKENPPVMLPAQETERAMEILKVLFNITFDSVKREVDEEDAALYRYLGTLLRHCVMVEAAGDRTEEFHGHTVNLLGNLPLKCLDVLLALELHEGSLEFMGVNMDVISALLAFLEKRLHQTHRLKECVAPVLNVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGDLLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTEEYREAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGHLTSLQDAMCETMEGQLSSDPDSDPD
Protein: CDKN1A interacting zinc finger protein 1 (F6VD24)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFSQQQQQQLQQQQQQLQQLQQQQLQQQQLQQQQLLQLQQLLQQSPPQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDQFAMPPATYDTAGLTMPTATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEKRTPAPEPEPC
Protein: Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase) (P42941)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Phosphoserine aminotransferase
- Threonine synthase
- Histidine biosynthesis trifunctional protein
- Serine hydroxymethyltransferase, cytosolic
- Alanine--glyoxylate aminotransferase 1
- Serine hydroxymethyltransferase, mitochondrial
- Tryptophan synthase
- Prephenate dehydrogenase [NADP
- Cystathionine beta-synthase
- Pyrroline-5-carboxylate reductase
Sequence:
MSKFVITCIAHGENLPKETIDQIAKEITESSAKDVSINGTKKLSARATDIFIEVAGSIVQKDLKNKLTNVIDSHNDVDVIVSVDNEYRQAKKLFVFDMDSTLIYQEVIELIAAYAGVEEQVHEITERAMNNELDFKESLRERVKLLQGLQVDTLYDEIKQKLEVTKGVPELCKFLHKKNCKLAVLSGGFIQFAGFIKDQLGLDFCKANLLEVDTDGKLTGKTLGPIVDGQCKSETLLQLCNDYNVPVEASCMVGDGGNDLPAMATAGFGIAWNAKPKVQKAAPCKLNTKSMTDILYILGYTDDEIYNRQ
Protein: Beta-casein [Cleaved into: Casoparan; Antioxidant peptide; Casohypotensin] (P02666)
Organism: Bos taurus (Bovine)
Function: Important role in determination of the surface properties of the casein micelles.
Subcellular location: Secreted.
Interaction partners:
- Alpha-S1-casein
- Kappa-casein
- Alpha-lactalbumin
- Alpha-S2-casein
- Beta-lactoglobulin
- Glycosylation-dependent cell adhesion molecule 1
- Lactotransferrin
- Chymosin
- Albumin
- Butyrophilin subfamily 1 member A1
Sequence:
MKVLILACLVALALARELEELNVPGEIVESLSSSEESITRINKKIEKFQSEEQQQTEDELQDKIHPFAQTQSLVYPFPGPIPNSLPQNIPPLTQTPVVVPPFLQPEVMGVSKVKEAMAPKHKEMPFPKYPVEPFTESQSLTLTDVENLHLPLPLLQSWMHQPHQPLPPTVMFPPQSVLSLSQSKVLPVPQKAVPYPQRDMPIQAFLLYQEPVLGPVRGPFPIIV
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Q6NWL6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Proteasomal ubiquitin receptor ADRM1
- Ubiquitin carboxyl-terminal hydrolase.
- 26S proteasome regulatory subunit 7
- Nuclear factor-related to kappaB-binding protein.
- Proteasome subunit beta
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 4
- Proteasome subunit alpha type
- Proteasome 26S subunit, non-ATPase 4.
Sequence:
MAGSAGEWCLMESDPGVFTELIKGFGCKGAQVEEIWSMEPENFENLKPVHGLIFLFKWQPGEEPAGSIVQDSRLDQIFFAKQVINNACATQAIISVLLNCTHPDMLLGETLTEFKEFSNSFDAAMKGLALSNSEVIRQVHNGFARQQMFEFDAKSTAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGVCNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEKKIVELQAQLTEEEPMDTDQSGNHLSSIQSEIAKYQLLIEEENQKLKRYKVENIRRKHNYLPFIMELLKTLAEYQQLIPLVEKAKEKQSAKKIQEAK
Protein: tRNA modification GTPase mss1, mitochondrial (Q9UTE7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
Subcellular location: Mitochondrion.
Interaction partners:
- Protein MTO1 homolog
- Pseudouridylate synthase C18B11.02c
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein uL11m
- rRNA methyltransferase 1, mitochondrial
- Mitochondrial GTPase 1
- Mitochondrial tRNA-specific 2-thiouridylase 1
- Large ribosomal subunit protein uL13m
- Multisubstrate pseudouridine synthase 7
- Putative acyl carrier protein, mitochondrial
Sequence:
MRILNRVFLNTFQACFRRFVHQIPTIYALSTPPGTSAVAIVRISGPNACKVAKTLAGSVPKPRIASLRTIKHPVRSEVIDKALMLYFKKPSSFTGEDVVELQLHGGTAVVDVTLEAIKQSGIPNIRYAKPGEFSERAFYNGRADLTQLEGLIDVINAQTAEQLYSANKEAHGSIYDICFRWRKKLIEYRAFLEASIDFSEEHELDDIETIKLFEELNEMKDEIDAHIEGGKCKEVLRKGINVAILGPSNAGKSSLINLLANRRISIVSPQSGTTRDAIEVLVDINGFPVLLSDTAGLRKGEDVQEIEKIGIEIAKARAEESQLTLFVFPINYHSFSESLKQSEILETIKDCLRQRKPIHFLINKVDCVSDYTTMFKPIKAYLQKNFLIPENRIHAVSCKTKEGLIDFLQALSSTFECMVNPLTNNKIQANLGWNERQRQCLSSCSSHLSLALQKSSDIVVAAEEVKLATEDIGRVTGAVDMENVFSVIFSKFCVGK
Protein: TRMT1-like protein (EC 2.1.1.-) (Q7Z2T5)
Organism: Homo sapiens (Human)
Function: May play a role in motor coordination and exploratory behavior.
Interaction partners:
Sequence:
MENMAEEELLPLEKEEVEVAQVQVPTPARDSAGVPAPAPDSALDSAPTPASAPAPAPALAQAPALSPSLASAPEEAKSKRHISIQRQLADLENLAFVTDGNFDSASSLNSDNLDAGNRQACPLCPKEKFRACNSHKLRRHLQNLHWKVSVEFEGYRMCICHLPCRPVKPNIIGEQITSKMGAHYHCIICSATITRRTDMLGHVRRHMNKGETKSSYIAASTAKPPKEILKEADTDVQVCPNYSIPQKTDSYFNPKMKLNRQLIFCTLAALAEERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCHLNKLKVVVDSKEKEKSDDILEEGEKNLGNIKVTKMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLHHGLDDIQTLIKTLIFESECTPQSQFSIHASSNVNKQEENGVFIKTTDDTTTDNYIAQGKRKSNEMITNLGKKQKTDVSTEHPPFYYNIHRHSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSILLKYSTPTYTGGQSESHVQSASEDTVTERVEMSVNDKAEASGCRRW
Protein: CXXC finger 1, like (CXXC-type zinc finger protein 1a) (Q6PGZ4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDSEVSDFEQPPGPERTLIRGNAPVYCVCRRPDINCFMIGCDSCSEWFHGDCIKISEKTAKTIRVWYCEKCRSKDETLEVKYRPKKSREKEAETDGPDTQPDTPDFKSDGRRGSRIKRSARMCGECEACLRTEDCGLCDFCKDMKKFGGPNKIRQKCRLRQCEVRARKMLRVKEEEYSMSKSRDYQDGPLSEEYSENELELYQQYCAGQYGDNGTGWNSDDDDGSYGESSLRKKAVKVKHVKRREKRSEKSEKKKEENKSRKHKPKQKHRDRVRHSERAEVRDSGGARQCLGPGCVEAARANSKYCSDDCGMKLAANRICEILPQRIQQWQQSPCIAEEQGKKFLERIRREQQLARMRLTEMEKRFHELEGIIAKAKQQVVQYDEEVNEGDDDTDLQIFCVSCSHSVNPKVALRHMERCYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKIPADEVCGCPLVRDVFEPTGEYCRVSKRKCNKHYCWEKLRRAEVDLERVRVWYKLDELFEQERNVKTAMTNRAGLMALMPHQTIQHDPITTDLRTSKDR
Protein: ATPase family AAA domain-containing protein 3 (Q20748)
Organism: Caenorhabditis elegans
Function: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. Important during development for the up-regulation of mitochondrial activity during the transition to higher larval stages. Regulates mitochondrial iron homeostasis. May play an important role in mitochondrial protein synthesis (By similarity). May also participate in mitochondrial DNA replication (By similarity). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (By similarity). Plays a role in regulating the production of reactive oxygen species in response to heat stress.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:19888333}; Single-pass membrane protein {ECO:0000269|PubMed:19888333}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q9NVI7}. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids. {ECO:0000250|UniProtKB:Q9NVI7}.
Interaction partners:
- Evolutionarily conserved signaling intermediate in Toll pathway
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein mL49
- Mitochondrial scaffolding protein 1
- Inorganic pyrophosphatase 1
- Probable complex I intermediate-associated protein 30, mitochondrial
- Mitochondrial Ribosomal Protein, Small
- Large ribosomal subunit protein uL24m
- Regulator of chromosome condensation
- Small ribosomal subunit protein uS14m
Sequence:
MSWLFGVQKNATPQIPDDFQAGAAPGGPQQPGQGQRQEGNSKMAYSFDSTALERAAKAARDLEKFPNAKEALELSRMQEVTRQKEVENETKKIEAQLANMKSEHIRVAEEERRKTLGEETKHAHSRAEYQDQLARKRAEEELAMKARMQEESLRKQEESVKKQEQLRKQTIEHELALKHKYELEKIDAETRARAKAARDNRDVNLEQMKLHEEENRKTVIEKIKTSGELIGSGLNQFLNDKTKIAAAVGGLTALAVGWYTAKRGTGVTARYIESRLGKPSLVRETSRITPLEVLKHPIKSVQMMTRQKKDPLNGVVLPPALERRLRDIAITTSNTKRNNGLFRNVMFYGPPGTGKTLFAKSLAQHSGLDYAVLTGGDIAPLGRDGVSAIHKVFDWASKSRKGLIVFIDEADAFLQKRSKNGMSEDTRAALNAFLFRTGEQSRKFMLVVASNQPEQFDWAVNDRFDQLVEFTLPGMEERERILLQYFNEHIVTPATSGSRSQRLKLDNFDWVAKCNEVAKKTSGMSGRELSKLVIGWQASAYASETGVLTEAIVDRNTADAMVQHEHKMEWLEKEQLKARNQEVKFGTTLKRETAV
Protein: UDP-glucose iridoid glucosyltransferase (EC 2.4.1.-) (UDP-glucose glucosyltransferase 7) (CrUGT7) (UDP-glycosyltransferase 76A2) (U3UA11)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: Iridoid glucosyltransferase acting on a broad range of substrates, including both 7-deoxyloganetic acid and 7-deoxyloganetin, curcumin, genistein, luteolin and kaempferol.
Interaction partners:
Sequence:
MGSVSAKKGVIVLVPYCLQGHMTPMLQLASILHSKGFSIIVAHTKFSSPNPSDHPEFIFHALPDKLNGFDTSFMNLLNVMEAINSSCGGPLVDYLVEIMKDKGQVISCIIHDAIMYFAEAVASQLNLPSMVLRTSNVAFMESHRDILRLHSENRFPLPDSELENPVPGLDPLRFKDLPVSVSSRIHDKIIEFFESYMNIRSNAAIIWNTTQVLEKYALNKLHHHYKVPSFAVGPFHKMVPASSSATSYINEDRGCIEWLDKQAPNSVLYMSLGSLSTIDEKELEETAWGLANSDQPFLWVIRPSSVNGSGWIEHLPEGFQEMVGDRGLLVKWAPQKEVLAHPAVGGFWSHCGWNSTLESICEAVPMICRPCFSDQIVNSRYITHVWKVGLELEQPSDRRVVEKTIRRLMVADSEEKEMRQRMLDLKTQIESSVQKGGSSYNSLNDLVKFIASFP
Protein: H/ACA ribonucleoprotein complex subunit NOP10 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10) (Q6Q547)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA. Essential for growth.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:9843512}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit GAR1
- H/ACA ribonucleoprotein complex subunit NHP2
- H/ACA ribonucleoprotein complex subunit CBF5
- 13 kDa ribonucleoprotein-associated protein
- Telomerase reverse transcriptase
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- Protein SHQ1
- Nucleolar protein 56
- tRNA pseudouridine synthase 4
- Nucleolar protein 58
Sequence:
MHLMYTLGPDGKRIYTLKKVTESGEITKSAHPARFSPDDKYSRQRVTLKKRFGLVPGQ
Protein: Agmatinase (A0A1D8PPP3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Ornithine decarboxylase
- Spermidine synthase
- Afp99p
- Corticosteroid-binding protein
- Polyamine oxidase
- Arginase
- asparagine--tRNA ligase
- Protein ARG5,6
- Phosphoacetylglucosamine mutase
Sequence:
MKLLALLTLLPLVISTNLEEKWGGLWPFQGIATFAHLEHFQCLIESEKQFDIGIIGVPFDTAVSYRPGARFGPRAIRDASQRQNNLRGFNPKALFDPYQSWARIIDCGDIPVTPMDNSAAYKQMSEAFKDLLNRKSSNNTEIPPRYIALGGDHSVLLPHIRALHKIYGPVNIIHFDAHLDTWKPNKYPTSEKNDINHGSMLWKAYEEGLTTKHNIHVGVRTRLSELDDLQDDDEQNFVRIEADDIWLKGPQWVVDKILATIPKDTATYISVDVDVLDPGFTSGTGTQEPGGFLPRELIYLLRSIDGLTVVGADVVEVSPAYDIAEITATNGAQIAYEVLTSMVKRGNIDKSLVKSVVHVFD
Protein: Growth factor receptor-bound protein 14 (GRB14 adapter protein) (Q9JLM9)
Organism: Mus musculus (Mouse)
Function: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14449}. Endosome membrane {ECO:0000250|UniProtKB:Q14449}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14449}. Note=Upon insulin stimulation, translocates to the plasma membrane. {ECO:0000250|UniProtKB:Q14449}.
Interaction partners:
- Insulin receptor
- Fibroblast growth factor receptor 1
Sequence:
MTTSLQDGQSAAGRAGAQDSPLAVQVCRVAQGKGDAQDPAQVPGLHALSPASDATLRGAIDRRKMKDLDVLEKPPIPNPFPELCCSPLTSVLSAGLFPRANSRKKQVIKVYSEDETSRALEVPSDITARDVCQLLILKNHYVDDNSWTLFEHLSHIGLERTVEDHELPTEVLSHWGVEEDNKLYLRKNYAKYEFFKNPMYFFPEHMVSFAAEMNGDRSPTQILQVFLSSSTYPEIHGFLHAKEQGKKSWKKAYFFLRRSGLYFSTKGTSKEPRHLQLFSEFSTSHVYMSLAGKKKHGAPTPYGFCLKPNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKDGMQLYQNYMHPYQGRSACNSQSMSPMRSVSENSLVAMDFSGEKSRVIDNPTEALSVAVEEGLAWRKKGCLRLGNHGSPSAPSQSSAVNMALHRSQPWFHHRISRDEAQRLIIRQGPVDGVFLVRDSQSNPRTFVLSMSHGQKIKHYQIIPVEDDGELFHTLDDGHTKFTDLIQLVEFYQLNRGVLPCKLKHYCARMAV
Protein: Osmolarity two-component system protein SSK1 (Q07084)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, maintained in a phosphorylated and inactive state by the phosphorelay intermediate protein YPD1. Under conditions of high osmolarity, the histidine kinase SLN1 is no longer active and the unphosphorylated form of SSK1 interacts with and activates SSK2 and SSK22, two MAPKKKs that further stimulate the PBS2-HOG1 MAPKK-MAPK cascade. Unphosphorylated SSK1 is subsequently degraded by the UBC7-dependent ubiquitin-proteasome system to down-regulate the HOG1 pathway after completion of the osmotic adaptation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14665464}.
Interaction partners:
- Serine/threonine-protein kinase SSK22
- MAP kinase kinase kinase SSK2
- Phosphorelay intermediate protein YPD1
- High osmolarity signaling protein SHO1
- MAP kinase kinase PBS2
- Serine/threonine-protein kinase STE11
- Mitogen-activated protein kinase HOG1
- Transcription factor SKN7
- Protein STE50
- Osmosensing histidine protein kinase SLN1
Sequence:
MLNSALLWKVWLRIDNSTDEVNQPIAVQFDEIDTVDDLKSRFFQKLSSTRWREINDNASIAIGLYAPKFDNQADNTSSNNTNDNSCRSKSNGAGSGANLSVNSNTKSSVSPTAGSFGLSKDLAKDRNVLQHPKPTQKRGALYDAFAAVPTVAATTNVDFPPNEAPMLSPQRPYSTSPKQFPATTKSPLLRFASVSPYPKFHSDNQIMASAGLTYVSPHNKNKYTRPLIRKGLNFTTESVNDCTYKIIFEPDELAINIYKELFGTMGSQPASQPLLIFSNVNLRQDVPPLDILNVVDYVPTNEEISQQKTQPTDHGAVGVFHLDDHISPGEQGLKQTIGDKADLKGKDGNSSPQEFKLITDEEQLRRASQELKDEEKDAESPWQAILLLPKGYKGGVDFRNKPVAHTDSSFNNEDTITHSELEVNTGSPSQESGSLNEAGIGITQPMSEVQRRKEDVTPASPILTSSQTPHYSNSLYNAPFAVSSPPDPLPNLFTTTSEKVFPKINVLIVEDNVINQAILGSFLRKHKISYKLAKNGQEAVNIWKEGGLHLIFMDLQLPVLSGIEAAKQIRDFEKQNGIGIQKSLNNSHSNLEKGTSKRFSQAPVIIVALTASNSQMDKRKALLSGCNDYLTKPVNLHWLSKKITEWGCMQALIDFDSWKQGESRMTDSVLVKSPQKPIAPSNPHSFKQATSMTPTHSPVRKNSNLSPTQIEL
Protein: Transmembrane protein 170A (Q8WVE7)
Organism: Homo sapiens (Human)
Function: Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26906412}; Multi-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:26906412}.
Interaction partners:
- Craniofacial development protein 1
- Breast cancer anti-estrogen resistance protein 1
Sequence:
MEREGSGGSGGSAGLLQQILSLKVVPRVGNGTLCPNSTSLCSFPEMWYGVFLWALVSSLFFHVPAGLLALFTLRHHKYGRFMSVSILLMGIVGPITAGILTSAAIAGVYRAAGKEMIPFEALTLGTGQTFCVLVVSFLRILATL
Protein: Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein homolog) (Q9WUK2)
Organism: Mus musculus (Mouse)
Function: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity).
Subcellular location: Cytoplasm, perinuclear region.
Interaction partners:
- Eukaryotic initiation factor 4A-I
- Eukaryotic translation initiation factor 4B
- Eukaryotic translation initiation factor 5
- Eukaryotic initiation factor 4A-II
- Eukaryotic translation initiation factor 4E
- Eukaryotic translation initiation factor 4 gamma 1
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 5B
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGGSRESRGGWDSRDDFNSGYRDDFLGGRGGSRPGDRRAGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
Protein: G protein gamma domain-containing protein (Q4Q1N4)
Organism: Leishmania major
Interaction partners:
Sequence:
MVLNLFSGAALNGHGSTHRRGRASSSLSSTGTGCRPQQQRYQASRSATDGASMQADGAEQSGSGVRAEAAEDRVLFNNCVAQVQRHLKTHADSPSTLHTLASYYTKTEPFIEGRPFCVTLSYATFLFHMQMARISVADVELYVQLVISALSQITEDDQLHHPFVQQVLRDHVFGLPSPTCRGAAHSVVLLSPQQYRAFATMTTALISLAVVPLSIVYQFHDRLETYCECASPLVANRALALLVQTVGEVRMDEQVTALQYILKTKPVKMNVDFLLACYERLKRAVIDPAHGPSFGRALSIHCSELFLRFRSPVRRDYVERFLYPSLCHSDMASFLEIPATRKHLLRELLSKCTPGMGTMNPFYMCLCAVLQSCFDNETDGALETVALIDCHMPHAAYFMSTLAVDSHMSVPMFAKVMISLARGAGMAMTGRETPDEVAASINENRTSVYNVLFLLREVVRSCSTTASRRATDMLKALRVAVAPKTIEALGKLSSEAFEAVSDITLDPQLLCAELAMVLHQDHIAEAMDSAVEYFRDVRSRCPCCAAARSSSLLCPVNGTVHVAGQSSVSRVLSTLSECAGAKAVEEKLISYLRDPALQMESAVHYLIYHIIANGGQHRNTLFVAVEPYVRSTLLALVSADRSGVRGLVDSTLKANVLMLHVKLVTLLASSIDPSYLESILKVFSELRVRNNHDALALWYMGNVLLRSCRGNLELLPTDPQENNYCVAFPGCAPASATTADNAQLVLKLLHRAHSFSPEMHKLVGCCVCKLIQDFNMQAPNICSTLLSPFGFFPVGLESLNAFALPAGASSTFWSFFLQQMRSAAPARTAFMATLAKSLSRRFRIASPRDALAPHGVEPTGHLFVIMVYEAMKRNPPLARVLLYMVSHWMKQAGHPPGKLACLVYVCVQLITVVVDRAEGPAAAEVEAETPQDRQQFDDAVKKAARVLKSQQARLDRLAPTARRENVEFFHLLRRLQRRVRRTVAAASGEIVVGDEAAEEDDDHDDAVDGSSAGGHVRQDSITDAVCAMQELQNAADNSVFDDYADDVDHEDDGAYGNNEGACDAASPGIGRSAQTGGSRDRAEGPSAPMRIRHLPQGITSILRSPARSSSNKSDWGATGAEKGLTTSVNTCRETNRQIDVEDVPHDADGDDAEMRGRDGKTAHSCALGVEPRTRSTSRGVQTDASLNSPALPGHAPQRNVGTSPIQPAGTSSHISVTRRNGTQLPCRAPADVGSARTPSSPLHQPQRSHTRPPEADGVLSEGTRTPAQRGSTWREPDLVDYVDGDTTPIDDYTGVPRLQATTTSDGIVLPSGMVLEYLRTHQGMDSLQHELRQFDQQWMVQQVAEYVSQNGGMVGAAGPSSALRGGVSSVQSVTVESRANNYSRPHADPTELAPTRTVRTEVRMIGPATSYSRPPRQEEHGPVVAAAPGLPEEGEVDVVDGEHPIRAVSGPPDESDLAGRAGDNDTTKRRRVEATEGSATTPLPPPVSPTSAFRGRNFFLNQHTQQEVDSTLQDIRYLQRRQQTNMSALAKAQSAAETVESAGDDGAPRKTPHQGQSSTGVAGEGVPPTTPYGQLILPTWIVEQRNDTAVRELRQVMGAHNPNDSRLSTSAGKRSRIHGSGAGDGSGNSAAWWAEMSSAPMPNYAADPQYSMELF
Protein: tRNAse Z TRZ4, mitochondrial (EC 3.1.26.11) (Long tRNase Z 2) (tRNase ZL2) (AthTRZL2) (F4J1H7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Zinc phosphodiesterase, which displays tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Can process the mitochondrial tRNA-like structures (t-elements).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19411372}.
Interaction partners:
- tRNase Z TRZ1
- tRNase Z TRZ2, chloroplastic
- tRNase Z TRZ3, mitochondrial
- Dynamin
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Xaa-Pro dipeptidase
- Small ribosomal subunit protein eS28x
- Integrator complex subunit
Sequence:
MLTSSMPQNLSLFGFSPLKSSSFALILRPFSLYPPIFASSSPAPSRRPPRTAGYRRSGPSPPRRKWSSFEEQKRKGRSPMEKDKAISFNHSSDSFEFNKRRAEGLDKVDKPKKNLKRNTRTLNPTNTIAYVQILGTGMDTQDTSPSVLLFFDKQRFIFNAGEGLQRFCTEHKIKLSKVDHIFLSRVCSETAGGLPGLLLTLAGIGEQGLSVNVWGPSDLKYLVDAMRSFIPRAAMVHTRSFGPSLNISDSAPQIGLSKPKDDAYVLVDDEVVKISAILLEPSRLEESGSKPGETAVIYVCELPEIKGKFDPKKAMALGLRAGPKYSYLQSGQSVKSDFKDITVHPSDVMGPSVPGPVVLLVDCPTESHAEELLSIPSMKTYYSCLDNSTDGAKLVNCIIHLSPASVTNSSTYRSWMKRFHSAQHILAGHEAKNMEFPILRASSRITARLNYLCPQFFPAPGFWSHQHDNNSINPTSLSKCFDSNLGESISAENLLKFTLRPHGNLGVDRSSIPSRLTALRVMDELLSEIPEISSKTEEIKQLWNGQHNKMMIEEPWLGESTVPSCLENIRRDDMEIVLLGTGSSQPSKYRNVTAIYIDLFSRGSILLDCGEGTLGQLKRRYGLEGADEAVRNLRCIWISHIHADHHTGLARILARRRELLKGLAHEPAIVVGPRSLKNFLDAYQRLEDLDMEFLDCRNTTTTSWASVETSRPEKNTSSGNAEGSLFSKGSLMQSIYKRPSSPLTDNSSALPFLKKLKKVLGEMGLEHLISFPVVHCPQAFGVSLKAAERKNIAGDEIPGWKMVYSGDTRPCPEMVEASKGATVLIHEATFEDALVEEAVAKNHSTTKEAIKVGSSAGVYRTVLTHFSQRYPKIPVIDESHMHNTCIAFDMMSINMADLHVLPKILPYFKTLFRNQVVEEEEEEEETDDDSLIRDKVPSFFIN
Protein: Leucine rich pentatricopeptide repeat containing (C9JCA9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYAIAAKEKDIQEESTFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLACPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLPISLQSIRSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKES
Protein: Phosphodiesterase (EC 3.1.4.-) (A0A8I6GJQ6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MPKKSKKEFYLKLRCRCSISRPKSLKHKKKKKLETITKRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAVHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNIRSSLQQPEGIDRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKPESSNYGASSSSTMIGFHVADALRRSNTKGCMSDGTYAPDYSLSAVDLKSFKNNLVDIIQQNKERWKELAAQGELDLHKNSEDLEEKHADTHP