wanglab/gogpt-training-data huggingface dataset:
Protein: Xaa-Pro dipeptidase (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Q7SXT5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MASSQQKAVYWLGNDTLRVSAALFALNRERLCVGLKALPDLQAGSVVVLQGGEQKQRYCTDTDETFRQESFFHWSFGVTEADCYGAIDVDSKKSLLFVPKLPESYATWMGEIFPPGHFKEKYAVDEVHFTTDIADVLAKMKPSVLLTLRGLNTDSGSTCREASFKGISRFEVNNSLLHPVIVECRLLKTDMELEVLRYTNRISSEAHKEVMRRVKPGLKEYEMESLFQHYCYSRGGMRHTSYTCICGSGNNSSILHYGHAGAPNDKTIQDGDMCLFDMGGEYYCYSSDITCSFPANGKFTADQRTIYEAVLKSSRAVMAAIKPGVKWTDMHRLADRVHLEELLKIGILHGDVEEMLKVHLGSVFMPHGLGHLLGIDVHDVGGYPEGVERVHEPGLKSLRMGRVVQERMVLTVEPGIYFINHLLDKALASPAQCGFINTAVLTRFRGFGGVRIEDDIAVTADGVELLTCVPRTVEEIEAFMAEETSKPFSPISSQKL
Protein: Protein dop1 (Q9C0Z4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in cellular morphogenesis. Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum (By similarity).
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein. Note=Late Golgi. {ECO:0000250}.
Interaction partners:
- Protein MON2 homolog
Sequence:
MNTIIDASNDAKYRKYQDAIRKCIALFQTVEQWPDYISFLTKLHKVLQTHSSFVNIPCSLLVSRALAECLSPGLPSGVHKKTLEVYDYIFTIIGSKTLTNELSTWSYGLTPFFSISSIKTKHDYINIIKKHYVSLGVGIRPCFQAVFISLLSGLEEDVDESSQEVYHLLDDLVKVLNDEKFAWGCIWSTILSFPSQRPGALAYLLRVCNNLAEEDIQTRVIQPDSGLVVRSFAAAISDNDILVQRGYMDALLNYFPIQSTFYKDVKPFDLKLLHMSVASIVLRNDLSLNRRFYAWLMGLSKDTELSISDSSITVDENTLQQNMAIFFEGVKDLLSSKNSLMSFYKAFRILYALSDRRPLFTIVESQILPCVLHSYETLTNVFHRDDSKHLYESAVDHGRRLIMKFSDSELHTFLFHCVNKIVANTTENSDSAEAVKFILDSQNFFFESINTEYSFIIFTNLLMHLEKTSPNSDVDGVSMTILTICKILLNNFDWNFFNYNNSAIDSYAKCTLNLDSDFENGILTYEILYKKCKCSLLSLLKQYIKDSHVHHEVLLISLNLIKEASDTEFENEFLDLSLQGFKDNSWSFQTLGSFVKQLPSRILINSTACVNVILDRIWCELCMFSYFREEELLSVIWTLQEKLQTRIIESYFSTCIVKEQLELRAPTIYYTPFYNLLKKSAQQSLFHFVFDRPLLLLLNSLLEDESGRDYTAMMNWINASSSLQLRVLELMTENLLSLSPNLTSVNSLETAMTRYNINEDQRNSEASRCVYFLKLCTRIISYFQDLHPKEGRLKSAKQVEELCLVTWADALLIQKKSLTYSSFLAFLVKLCLDIVLTPQNIKTSTDVYIIQTWALRLLYQITSIWENPLKFESSLIVGLFALVQEVERSPSSTYRSFILSLLQMLEFLLSRLDGTIDLSSEQHYLLSNFVLVGMLNDDPGLSPKWLHAIKKLLPLLLQNLQLLMVNPIQSLCKFVHSFLDQHESMYLKYPDPVKDYACMDVFIAKLKMLSELVSAALLEFTYSPGPKKSNLEANGIIGNVISGVFAAESSGVSIDVNKRLSMLLTMQDALQTLFLSYSWHIRSSYADKTSKVFMNDSSVLKEASLSGLKEFYFCEPLECVETLVQIYLENNVECCQCIWDIFSFLSDSEPQYIVKQLVSSFFAREGIASYAGPSSLTAKITQLDILCCMSDFVSRVEGENTSKIFTEISKFVREIISSSNSFKNYLLVCLRMLLEVAKNVNTYCESRQQKDFIDLMGKTLSSVLFHAGKSSDPNLTVDFLAYHKAAADTFEVAKTQKKTSSVYLFVKYLDPSLLDFFCSEFVPKITELSKEEDKLVAWATSIVNVFITPLVKARTFPESLTTYHLDLLLVLSKHPFLSKSWRRDFWEIFNDNSLFRFDIDQLRKLSPVIYTALYQEISRLNDLITKSDLGVTTLFTSRDTQLGARQSNICRITILMLSSPRDFFLPSLPPLIDLVKRLITSDPEGVLKKDLFLFIRALALRTSSKHLLPLWPIVVSELLIIFKSYCMPNVAISKETLLDACRLLDFLTALKLEEFALHEWVVMLSPLDAVYWSGKTSRKSLVQKVSERLQEQASEKDDKSSVESEHSILTSTTRTPSLGIYTTDAQLRNFLNRISIDAYEESYSFSTIDIQSFENSIYREVLQRFSNAPLSPFSSIKAPSSLAGSSN
Protein: Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GAR synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIR synthetase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase)] (P07244)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Phosphoribosylformylglycinamidine synthase
- Amidophosphoribosyltransferase
- Phosphoribosylaminoimidazole carboxylase
- Adenylosuccinate lyase
- Phosphoribosylglycinamide formyltransferase
- Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Bifunctional purine biosynthesis protein ADE17
- Bifunctional purine biosynthesis protein ADE16
- Adenylosuccinate synthetase
- Imidazole glycerol phosphate synthase hisHF
Sequence:
MLNILVLGNGAREHVLVTKLAQSPTVGKIYVAPGNGGTATMDPSRVINWDITPDVANFARLQSMAVEHKINLVVPGPELPLVNGITSVFHSVGIPVFGPSVKAAQLEASKAFSKRFMSKHNIPTASYDVFTNPEEAISFLQAHTDKAFVIKADGIAAGKGVIIPSSIDESVQAIKDIMVTKQFGEEAGKQVVIEQFLEGDEISLLTIVDGYSHFNLPVAQDHKRIFDGDKGLNTGGMGAYAPAPVATPSLLKTIDSQIVKPTIDGMRRDGMPFVGVLFTGMILVKDSKTNQLVPEVLEYNVRFGDPETQAVLSLLDDQTDLAQVFLAAAEHRLDSVNIGIDDTRSAVTVVVAAGGYPESYAKGDKITLDTDKLPPHTQIFQAGTKYDSATDSLLTNGGRVLSVTSTAQDLRTAVDTVYEAVKCVHFQNSYYRKDIAYRAFQNSESSKVAITYADSGVSVDNGNNLVQTIKEMVRSTRRPGADSDIGGFGGLFDLAQAGFRQNEDTLLVGATDGVGTKLIIAQETGIHNTVGIDLVAMNVNDLVVQGAEPLFFLDYFATGALDIQVASDFVSGVANGCIQSGCALVGGETSEMPGMYPPGHYDTNGTAVGAVLRQDILPKINEMAAGDVLLGLASSGVHSNGFSLVRKIIQHVALPWDAPCPWDESKTLGEGILEPTKIYVKQLLPSIRQRLLLGLAHITGGGLVENIPRAIPDHLQARVDMSTWEVPRVFKWFGQAGNVPHDDILRTFNMGVGMVLIVKRENVKAVCDSLTEEGEIIWELGSLQERPKDAPGCVIENGTKLY
Protein: CG5272 protein (CG5272-PA) (Giant nuclei) (Gnu protein) (LD12084p) (Q9VUI0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- DNA replication inhibitor plutonium
- non-specific serine/threonine protein kinase
- Protein matrimony
- Thioredoxin-1
- Maternal effect protein oskar
- Poly
- Tubulin alpha-4 chain
- LD24340p
- Deubiquitinase otu
- Chorion peroxidase
Sequence:
MERYNRVYRDPASPLTPLTPLSTEAFTFEDVTPTGGVGRKGTARYGLFGMPKNNNLTVPNSRPALSGLKRLSESTLPRRFSQKFMRTRSVFSPTSQSTLINGETRLLGESGDSKLLRTKREDRPKPDIRLQQETRLRQEESKLKSARKIKVEDPRSPTPSIHHSRYKPCSPVEHPTLSPRVKSLLDRTGNAHLTELFTRQEIDIEVLIQMTLEDLAALGVRGAREIRLAMNIIQLAKQFF
Protein: Sigma-54 dependent response regulator (Q9KQ67)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Interaction partners:
- histidine kinase
- histidine kinase
- Sensory histidine kinase/phosphatase NtrB)
- histidine kinase
- RNA polymerase sigma-54 factor
- histidine kinase
- Aerobic respiration control sensor protein
- histidine kinase
- Pyruvate-flavoredoxin oxidoreductase
- Flagellar assembly protein FliH
Sequence:
MKMAQSKVLIVEDDEGLREALIDTLALAGYEWLEADCAEDALLKLKSHSVDIVVSDVQMAGMGGLALLRSIKQHWPNLPVLLMTAYANIQDAVSAMKDGAIDYMAKPFAPEVLLNMVSRYAPVKSDDNGDAVVADTKSLKLLALADKVAKTDANVMILGPSGSGKEVMSRYIHNASPRKEGPFIAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQAKLLRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVQAGHFREDLYYRLNVFPLTWPALCERKDDIEPLANHLIERHCKKLGLPVPSIAPNAITKLLNYPWPGNVRELDNVVQRALILSENGHIQSEHILLEGVDWHDASSLQQAVAGESMAAPQIKPVAEPEVFKPLVQGGGQNSSSQSSGLGGELRDQEFAIILDTLAECQGRRKEMAEKLGISPRTLRYKLAKMRDAGIDIPG
Protein: Protein GMH1 (GEA1-6 membrane-associated high-copy suppressor protein 1) (P36125)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:12808035}; Multi-pass membrane protein {ECO:0000269|PubMed:12808035}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12808035}; Multi-pass membrane protein {ECO:0000269|PubMed:12808035}. Note=Recycles between Golgi apparatus and endoplasmic reticulum.
Interaction partners:
- ARF guanine-nucleotide exchange factor 1
- ARF guanine-nucleotide exchange factor 2
Sequence:
MSYLPTYSNDLPAGPQGQRRRNNGNENDARQGYGQQSVPMVIRRLFKTPKNLDLETASWEMFHLIFHPRKAYRSIYYQRQTKNQWARDDPSFFIFQIALISLSSIIWSIYNSGFNNDSDMGALSIIGHFFKSLVMMVILDFFIFGFIMATIFYLLLNRSHFKFKSSQNSVVEWAYCFDVHCNSFLIILLCLYFIQFLLLPIINLQNWISLLIGNSLYCFAIGHYFILTFYGYNQLPFLKNLNFILLPTLGLSIIYLISLFGIDLSKKLSFYNY
Protein: MIP20740p (Smooth, isoform J) (D5AEJ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNNLNANASAFLWQVPPPQQLTPQSVQQQTVQSVQSMQSVQHSQLLQSAVVSQPRKFGGNKSNYNYMQNHAIMGPGGGPMGGIGGNPNIYRKRHSINTYNAGLYQTNVATLSTPQQHVSHQHHHHLRQQQQQQHQQQAPQQQPHPQHLHHQQQLVAPAQSHNLYQFKEPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN
Protein: Pentatricopeptide repeat-containing protein At5g12100, mitochondrial (Q9FMQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Plant self-incompatibility protein S1 family
- F14J9.2 protein
- Putative purine permease 19
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Regulator of Vps4 activity in the MVB pathway protein
- Jacalin-related lectin 5
- Plant self-incompatibility protein S1 family
- Auxin-responsive protein SAUR77
- Phosphorylated adapter RNA export protein
- Transcription factor bHLH94
Sequence:
MVTRLRLVSRSSRYATVKFTDSVSACSCRRLFSASTDPEPESQPEQAPPTNPVTGDEKLRNLRVLLQQNRIETARGVLSSLLRSDSTPFASPKELFSAFSLSSPSLKHDFSYLLLSVLLNESKMISEAADLFFALRNEGIYPSSDSLTLLLDHLVKTKQFRVTINVFLNILESDFRPSKFMYGKAIQAAVKLSDVGKGLELFNRMKHDRIYPSVFIYNVLIDGLCKGKRMNDAEQLFDEMLARRLLPSLITYNTLIDGYCKAGNPEKSFKVRERMKADHIEPSLITFNTLLKGLFKAGMVEDAENVLKEMKDLGFVPDAFTFSILFDGYSSNEKAEAALGVYETAVDSGVKMNAYTCSILLNALCKEGKIEKAEEILGREMAKGLVPNEVIYNTMIDGYCRKGDLVGARMKIEAMEKQGMKPDHLAYNCLIRRFCELGEMENAEKEVNKMKLKGVSPSVETYNILIGGYGRKYEFDKCFDILKEMEDNGTMPNVVSYGTLINCLCKGSKLLEAQIVKRDMEDRGVSPKVRIYNMLIDGCCSKGKIEDAFRFSKEMLKKGIELNLVTYNTLIDGLSMTGKLSEAEDLLLEISRKGLKPDVFTYNSLISGYGFAGNVQRCIALYEEMKRSGIKPTLKTYHLLISLCTKEGIELTERLFGEMSLKPDLLVYNGVLHCYAVHGDMEKAFNLQKQMIEKSIGLDKTTYNSLILGQLKVGKLCEVRSLIDEMNAREMEPEADTYNIIVKGHCEVKDYMSAYVWYREMQEKGFLLDVCIGNELVSGLKEEWRSKEAEIVISEMNGRMLGDVTVDEDLSATEKL
Protein: Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF (L-Ara4N-phosphoundecaprenol flippase subunit ArnF) (Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF) (P76474)
Organism: Escherichia coli (strain K12)
Function: Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE
- Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase
- Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
- Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
- UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase aminotransferase)
- Bifunctional polymyxin resistance protein ArnA
- UDP-glucose 6-dehydrogenase
Sequence:
MGLMWGLFSVIIASVAQLSLGFAASHLPPMTHLWDFIAALLAFGLDARILLLGLLGYLLSVFCWYKTLHKLALSKAYALLSMSYVLVWIASMVLPGWEGTFSLKALLGVACIMSGLMLIFLPTTKQRY
Protein: 2-keto-4-pentenoate hydratase (EC 4.2.1.80) (2-hydroxypentadienoic acid hydratase) (P77608)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.
Interaction partners:
- 4-hydroxy-2-oxovalerate aldolase
- 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase
- Acetaldehyde dehydrogenase
- 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
- 3-
- DNA-binding transcriptional activator MhpR
- 3-phenylpropionate/cinnamic acid dioxygenase subunit beta
- 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha
- 2-keto-3-deoxy-L-rhamnonate aldolase
- 5-keto-4-deoxy-D-glucarate aldolase
Sequence:
MTKHTLEQLAADLRRAAEQGEAIAPLRDLIGIDNAEAAYAIQHINVQHDVAQGRRVVGRKVGLTHPKVQQQLGVDQPDFGTLFADMCYGDNEIIPFSRVLQPRIEAEIALVLNRDLPATDITFDELYNAIEWVLPALEVVGSRIRDWSIQFVDTVADNASCGVYVIGGPAQRPAGLDLKNCAMKMTRNNEEVSSGRGSECLGHPLNAAVWLARKMASLGEPLRTGDIILTGALGPMVAVNAGDRFEAHIEGIGSVAATFSSAAPKGSLS
Protein: LD37115p (Q960S7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAGAAFCIGLKYAGTENLVAFATLRSVIKDFLRFPSRPMGECAGRTTVESCLMVLLISISLVFAGSGNCEILRIIRFLRSRVGPQYPHITYGSHMAIHMSLGLLFLGAGRFTISQTPESIAALVCAFFPKFPIHSNDNRYHLQALRHLYVLAVEPRLFLPRDIDTNKLCLANISVLEVGATELRRLPIAPCILPVLSTLQQVVVDDENYWPVCFERSRNWDQLEKALEMSAPIDIKKRTGCLSHLEDPDRLKSMLAQTLTMEQSICWQIDMNDLQQFASERMVKQFLSRCLDTKGTDLSPPELMKRHQVMLLFYNAVVKDRMHFLPVYLTLYDHVTKSMPNNIDVWQMKLIDAYLSRSQESEHPLISVELIQMMQELFKQEMEDSTRELCLPLREFLSRRRLDPSYVTTVSGPDLQRAFCVINYYNLLPNMLNGVDLSTGTVNYMRLLYEFRRLNLGAHTIFGLMKILQSLATEVVTLDEAALLAYTMGDQ
Protein: cDNA FLJ56479, highly similar to Eukaryotic translation initiation factor 4 gamma 1 (B4DGF1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNTPSQPRQGGFRSLQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVAPTQQYPVQSGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASVAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Protein: ATP-binding cassette sub-family A member 9 (EC 7.6.2.-) (Q8K449)
Organism: Mus musculus (Mouse)
Function: Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRKRHLRLGQQMWALLCKNWLRKFRMRRETLLEWLFSLLLILFVYQLSSNLHQVHDAPEMSVVDLGRVDNFNDSNYMMVFAPESEATHEIMNKVASAPFMKGRTIVACPDEKSMNELDLNYSIDAVRVIFKDTFSYHLKFSWGQRIPKTKEHKDHSAPCEPLNNKMICENSAFWEKGFVAFQAAINAGIIEMITNHSVMEELMSVIGSNMKMPPFIAQGGVATDFFIFFCVISFSSLIYYLSVNITQERQYMTTLMAMMGLRESAFWLSWSLMYAGFILVVAVLMSLIVKSAQVVVLTGFMVVFLLFLFYGLSLITLSFLMSVLIKKPFLTGLAIFILTVFWGSLGFTALYKHLPAFVEWTLCFLSPFAFTTGMAQLIHLDYDVNSNVNLNSPNNSYLIMATLFMLVLDALLYLVLALYFDKITLSKYGHQRSPLFFLKSSYWFKRRGASHVVLENEIDSDPSLNDSLEPVSPEFQGKEAIRIKNLKKEYSGKHGKVEALRGLGFDIYEGQITALLGHSGAGKTTLINTLSGLSPPTTGSVTIYNQTVSEMDDSDAVLTITGVCPQSNVQFGFLTVRENLRLFAKIKGILPHEVEQEVQQVLQDLEMENIQDILAQNLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKERRAGRVIVFSTQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGIGYHLSLHLNEACDPEGITSLVKKHISDARLTTQSEERLVYILPLERTNKFPDLYRDLDRCSNQGIEDYGVSMTTLNEVFLKLEGKSMADESDVGICGRLQSDGARDMESLVELEQVLSLDSSGSSVSGMALWRQQLCAVAKVRFFKLKNERKSLMTVLLLFGISFVPQLLEHLVYKVYHKSYSWGLSPSMYFLSPGQPPQDPLTHLLVINRTGSSIDNFVHALRQQGIALDLDALGTRNGTEEALYNGAITVLGEEKALRFSVACNAKRLNCFPVLMDIISNGLLGIFNSSERIQTDRSTVFEEHMLYEYGFMSNAFFWIPVAASLTPYIAMGSISDHKKKVLSQLWTSGLYPSAYWCGQALVDIPIYFLILFLMQIMDSVFSSEEFISVMESLLIQIPCSIGYASSLIFMTYVISFIFRNGRKNSGIWSFFFLIVTIFFIIATDINEYGFLELLICTFLVPPFTLIGSLLIFSEVSYDSVDYLGTSESQLVFLALLIPYLHFLLFFFILRCLERYLRKKSLRVDPVFRISPRSCPAVPNPEEPGEEDEDVQMERVRTTGAMATLQTDEKPVIIASCLRKEYIGRTKRCFSKMKKKIATRNISFCVKKGEVLGLLGHNGAGKSTTISMITGDTIPTAGQVFLKGSGGGAALGFLGYCPQENVLWPNLTVKEHLELYAAVKGLKKKDAVVTITRLVNALKLQDHLKALVRTLSEGVKRKLCFVLSILGNPPVVLLDEPSTGMDPEGQQQMWQAIRATFTNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKTPSQVEPLNTEIMRLFPQAARQERYSSLMVYKLPVEDVRPLSEAFFKLERLKENFDLEEYSLSQSTLEQVFLELSKEQELDDFGEEANSSVKWKLLPQEEL
Protein: Nuclear GTPase SLIP-GC (EC 3.6.1.-) (Speckled-like pattern in the germinal center) (D3YWJ0)
Organism: Mus musculus (Mouse)
Function: Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (By similarity). Reduces somatic hypermutation in B-cells which may enhance genome stability.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:22833677}.
Interaction partners:
Sequence:
MEEMEALVGVVPHSADCDLFKEPVRKRRRLHRDRQFQAFPSAEQSALKEYEKLECRTRRVLSNTYQKLIQSVFLDDSIPSGLKYLINRLLALIEKSPLEPVYVGFLGITGAGKSSLINALIRQAMFLPVSGESVCTSCIVQVSSGCCEQYEAKIHLLSDQEWKAELKDLTKLLHRAEQSGEEEADLWDRDDATEEAAQKLRMLYGHGAERRHYEELLRLKPRGRIPNSRTITLKAEEAGELSVKLDPYIRTRRRDWDGESAETQIWPLIKYVEVILPKSALIPEGVVLVDIPGTGDFNSKRDKMWKKTIDKCSVIWVISDIERVSGGKTHEDLLSESIKACQRGFCRDIALVVTKTDKLHLQEYLRERKMGNQAIQSQREAVLQRNEIIKLQRKRMLKEKLKRKLPADSKVLEASDLVYTVSAHEYWQRTILTEEESEIPKLREYIRKRILDKKRRLVTKYVTEAFGLLLLTDTLNTEESLLTEELNTGGLRQFVEEKMELLEKAIEQCFARMEQPLQTGVQVAMTSYRRILGSCLVRSRGNQGFHQTLKAVCLKNGVYASRTLARIDLNEALSQPIYDQIDPVFGGIFRDGKPTAPALMQHIDAFKHSLEERMAEVGVRSGWKQDGYKRSFLIQEISAILGGLESHILRRKRKIYKSVTSSIQNDLKPCYEEAAQITGKKACERMKDVIRRGVERQVAEGLFERAQERMWHQFRQLKHGITEKVKGSITTMLTLAAPQGVGLCKELADVRNEQKEMEKLYRSLREVAENAQLRRSMQDFLLRMSPSKAGPHGTKL
Protein: Proline-rich protein 3 (MHC class I region proline-rich protein CAT56) (P79522)
Organism: Homo sapiens (Human)
Interaction partners:
- Splicing factor 3A subunit 2
- Probable ATP-dependent RNA helicase DDX46
- Splicing factor 3A subunit 1
- Cell division cycle 5-like protein
- Splicing factor 3A subunit 3
- BLACAT1 overlapping LEMD1 locus
- Splicing factor U2AF 65 kDa subunit
- RNA-binding motif protein, Y chromosome, family 1 member F/J
- Heterogeneous nuclear ribonucleoprotein K
Sequence:
MPKRKKQNHHQPPTQQQPPLPEREETGDEEDGSPIGPPSLLGPPPMANGKPGDPKSALHRGPPGSRGPLIPPLLSLPPPPWGRGPIRRGLGPRSSPYGRGWWGVNAEPPFPGPGHGGPTRGSFHKEQRNPRRLKSWSLIKNTCPPKDDPQVMEDKSDRPVCRHFAKKGHCRYEDLCAFYHPGVNGPPL
Protein: P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) (P51577)
Organism: Rattus norvegicus (Rat)
Function: Receptor for extracellularly released ATP acting as a ligand-gated ion channel that plays multiple role in immunity and central nervous system physiology. Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (By similarity). Upon activation, drives microglia motility via the PI3K/Akt pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15985462}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F8W463}. Lysosome membrane {ECO:0000269|PubMed:24817123}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- P2X purinoceptor 6
- P2X purinoceptor 2
- P2X purinoceptor 3
- P2X purinoceptor 5
- P2X purinoceptor 1
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 2D
- Glutamate receptor ionotropic, NMDA 2C
- P2Y purinoceptor 6
Sequence:
MAGCCSVLGSFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVIPAQEENSLFIMTNMIVTVNQTQSTCPEIPDKTSICNSDADCTPGSVDTHSSGVATGRCVPFNESVKTCEVAAWCPVENDVGVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNAQTDPFCPIFRLGTIVEDAGHSFQEMAVEGGIMGIQIKWDCNLDRAASLCLPRYSFRRLDTRDLEHNVSPGYNFRFAKYYRDLAGKEQRTLTKAYGIRFDIIVFGKAGKFDIIPTMINVGSGLALLGVATVLCDVIVLYCMKKKYYYRDKKYKYVEDYEQGLSGEMNQ
Protein: NTF2 domain-containing protein (G0SG92)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
Interaction partners:
- mRNA export factor MEX67
- Putative SAC3 family protein
Sequence:
MISSGSSHVVSAKSFVEWYYRQINENKPVASGYVNNNATYTKAGHPPADITINGRVVATPEEWDTMLKEQRAQHNTSSSSTLPIGRKPVRYDVDCFDVHVINADYRFAAPQRMIEQHAPTDGVRMMMALTVSGSVYFGASPRSTDDYVIKQHFNDVFILVPNWDVLEKPGARSGRKYLIASHKYRAY
Protein: COMM domain-containing protein 1 (Protein Murr1) (Q8N668)
Organism: Homo sapiens (Human)
Function: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1. Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner.
Subcellular location: Nucleus {ECO:0000269|PubMed:21778237, ECO:0000269|PubMed:28604741}. Cytoplasm {ECO:0000269|PubMed:21778237}. Endosome membrane {ECO:0000269|PubMed:18940794}. Cytoplasmic vesicle {ECO:0000269|PubMed:18940794}. Early endosome {ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:25355947}. Recycling endosome {ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:21741370}. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.
Interaction partners:
- Cullin-2
- Coiled-coil domain-containing protein 22
- COMM domain-containing protein 6
- VPS35 endosomal protein-sorting factor-like
- Coiled-coil domain-containing protein 93
- Histone acetyltransferase KAT2A
- COMM domain-containing protein 10
- Copper-transporting ATPase 2
- COMM domain-containing protein 9
- COMM domain-containing protein 4
Sequence:
MAAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQILKTLSEVEESISTLISQPN