wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium channel protein (Q20JQ9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
Interaction partners:
Sequence:
MAHMFTPPGPQSLRKFTRESLKAIESRIAEENAKKSKNTEERNKDNECSRKPNSGLEAGKTLPFIYGEVPKGLVSTPLEDLDQFYSNHTTFIVVSKKKEIYRFNATPALYIFSSFNLLRRISIQILVHFLFNFIIICTILANCAFMVYTQTPDWAKNVEYVFTGIYTLEALVKITARGFCVGRFTFLRDPWNWLDFIVIVMAYVTEFVDLGSVSALRAFRVLRALKTISVVPGLKTIVGALIQSVKKLSDVMILTLFCLSVFALVGLQLFMGILKQKCVYSTSFTENKEACYKNKTCRDYINNPSNQYFLPGKKDALICGNSSDAGQCPEGYTCLKAGKNPDYGYTSFDSFGWAFLSLFRLMTQDFWENLYQQTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYDEQNQATIDEALKKEEEFNAMLEQITRQEQEAEAAAEQSKCEGLSGEKTDSSSDASKLSSKSAKERRNRKKKRQHQGESEKEEDSIKEGNDRKPNFTFAVDGKIRRSRDRSYTSPRQSPLSFQGSLLTPRRDSKASVFSFRGRIHSDNNYADDEQSMFEETGSRRDSLFLPTRPERLFSNVSKSSLTPHLLLPSNGKARYVDDSNGMVMVTSGASAPNSPVIALNTPEVSRKRAMFDDTCADSDDERRSRCNSQNFSKAYRQSMRERALSVASGSNNPAECSEIFKQRCEEWWFEFAENYLIWDCSPTWLRIKEVVHMIVMDPFADLFITICIVINTVFMAMECYPMDGPYSSMLSTANVVFIGIFTAEMIFKVIALDPYSYFLEGWNIFDSIIVTLSLMELCLANVLSGIGFLRPFRLLRVFKLAKSWPTLNMLIKIIGNSLGALSNLTLVLAIIVFIFAVVGMQLFGKSYGECVCKISSDCMLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQPLCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAVSGEEDENNLQIAVRRIRKGFTFIKTCLQSFFRSGCLRKKKQKSADGNMIVNCKERKDSTNHTTIELVKSTGGTDLDSDTENFISNPSLTVSVPIAAEESDFECLNTEDFSSLSSDLEEDKEKLSDVASSFSEGSTVDLRPLGKDGEDALELVLEEEAYPEPCFTAGCVRRFRCCQVDEEKGIWKKWWLLRQTCYNIVEHSWFETFIVFMILLSSGALAFEDIYLDTRKSVKTILEFADKVFTYIFILEMLLKWVAYGFAKYFTNLWCWLDFVIVDVSLISLVANALNYSELSAIKSLRTLRAFRPLRALSRFDGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIVGVNFFAGKFSECINITTEQRLPVSEVYNKTDCERMGKGVRWRNVIINFDNVGNGYLALLQVATFKGWMPIMYAAVDSRNPEEQPEYEVNLYMYLYFVIFIILGAFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPKNKIQGLIFDLVTKQAFDIFIMVLIWLNMVTMMLETEDQSIEMTRALYWINVIFIVLFTTECVLKMIALRHYFFTVGWNVFDFIVVILSIVGMSLTEVIKKYFVSPTLFRVIRLARIGRVLRLIRSAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKTAGIDDMFNFETFPNSMLCLFQITTSGGWDGLLAPMLNSKPPDCDPTKNFTGSSVVGDCGNPSIGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFDRFYEVWEKFDPKATQFMEYGKLSDFADSLDPPLRIPKPNRFQLMSMDLPMVTGDRIHCLDILFAFTKRVLGEGGEMDMLHGQMEDRFMQSNPSKSSYEPITTTLRRKHEDMSAAVIQRAFRKHLVRDSMKKVRNFKKKNKHQNGKVPSNQSMDKDMCNEDSDATAATSSPPSYSSITENAKNKYEKDKHEKEVGDKGNQVKKK
Protein: DNA helicase/primase (EC 2.7.7.-) (EC 3.6.4.12) (Gene product 4) (Gp4) (P03692)
Organism: Escherichia phage T7 (Bacteriophage T7)
Function: ATP-dependent DNA helicase and primase essential for viral DNA replication and recombination. The helicase moves 5' -> 3' on the lagging strand template, unwinding the DNA duplex ahead of the leading strand polymerase at the replication fork and generating ssDNA for both leading and lagging strand synthesis. ATP or dTTP hydrolysis propels each helicase domain to translocate 2 nt per step sequentially along DNA. Mediates strand transfer when a joint molecule is available and participates in recombinational DNA repair through its role in strand exchange. Primase activity synthesizes short RNA primers at the sequence 5'-GTC-3' on the lagging strand that the polymerase elongates using dNTPs and providing the primase is still present.
Interaction partners:
Sequence:
MDNSHDSDSVFLYHIPCDNCGSSDGNSLFSDGHTFCYVCEKWTAGNEDTKERASKRKPSGGKPMTYNVWNFGESNGRYSALTARGISKETCQKAGYWIAKVDGVMYQVADYRDQNGNIVSQKVRDKDKNFKTTGSHKSDALFGKHLWNGGKKIVVTEGEIDMLTVMELQDCKYPVVSLGHGASAAKKTCAANYEYFDQFEQIILMFDMDEAGRKAVEEAAQVLPAGKVRVAVLPCKDANECHLNGHDREIMEQVWNAGPWIPDGVVSALSLRERIREHLSSEESVGLLFSGCTGINDKTLGARGGEVIMVTSGSGMGKSTFVRQQALQWGTAMGKKVGLAMLEESVEETAEDLIGLHNRVRLRQSDSLKREIIENGKFDQWFDELFGNDTFHLYDSFAEAETDRLLAKLAYMRSGLGCDVIILDHISIVVSASGESDERKMIDNLMTKLKGFAKSTGVVLVVICHLKNPDKGKAHEEGRPVSITDLRGSGALRQLSDTIIALERNQQGDMPNLVLVRILKCRFTGDTGIAGYMEYNKETGWLEPSSYSGEEESHSESTDWSNDTDF
Protein: rRNA-processing protein UTP23 homolog (Q9BRU9)
Organism: Homo sapiens (Human)
Function: Involved in rRNA-processing and ribosome biogenesis.
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- KRR1 small subunit processome component homolog
- WD repeat-containing protein 43
- Probable U3 small nucleolar RNA-associated protein 11
- Neuroguidin
- U3 small nucleolar ribonucleoprotein protein IMP3
- Probable ATP-dependent RNA helicase DDX52
- Something about silencing protein 10
- U3 small nucleolar ribonucleoprotein protein IMP4
- U3 small nucleolar RNA-associated protein 14 homolog A
- WD repeat-containing protein 46
Sequence:
MKITRQKHAKKHLGFFRNNFGVREPYQILLDGTFCQAALRGRIQLREQLPRYLMGETQLCTTRCVLKELETLGKDLYGAKLIAQKCQVRNCPHFKNAVSGSECLLSMVEEGNPHHYFVATQDQNLSVKVKKKPGVPLMFIIQNTMVLDKPSPKTIAFVKAVESGQLVSVHEKESIKHLKEEQGLVKNTEQSRRKKRKKISGPNPLSCLKKKKKAPDTQSSASEKKRKRKRIRNRSNPKVLSEKQNAEGE
Protein: Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Omnipotent suppressor protein 1) (P12385)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Translation initiation factor RLI1
- Eukaryotic peptide chain release factor GTP-binding subunit
- ATP-dependent helicase NAM7
- Elongation factor 1-alpha
- eRF1 methyltransferase catalytic subunit MTQ2
- Nonsense-mediated mRNA decay protein 3
- Protein DOM34
- Nonsense-mediated mRNA decay protein 2
- Polyadenylate-binding protein, cytoplasmic and nuclear
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MDNEVEKNIEIWKVKKLVQSLEKARGNGTSMISLVIPPKGQIPLYQKMLTDEYGTASNIKSRVNRLSVLSAITSTQQKLKLYNTLPKNGLVLYCGDIITEDGKEKKVTFDIEPYKPINTSLYLCDNKFHTEVLSELLQADDKFGFIVMDGQGTLFGSVSGNTRTVLHKFTVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAEVAVQNFITNDKVNVKGLILAGSADFKTDLAKSELFDPRLACKVISIVDVSYGGENGFNQAIELSAEALANVKYVQEKKLLEAYFDEISQDTGKFCYGIDDTLKALDLGAVEKLIVFENLETIRYTFKDAEDNEVIKFAEPEAKDKSFAIDKATGQEMDVVSEEPLIEWLAANYKNFGATLEFITDKSSEGAQFVTGFGGIGAMLRYKVNFEQLVDESEDEYYDEDEGSDYDFI
Protein: Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] (Q14457)
Organism: Homo sapiens (Human)
Function: Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in antiviral host defense.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19713971, ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:22498477, ECO:0000269|PubMed:25484083}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19050071}; Peripheral membrane protein {ECO:0000269|PubMed:19050071}. Endosome membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Mitochondrion membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Endosome {ECO:0000250|UniProtKB:O88597}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19050071}.; SUBCELLULAR LOCATION: [Beclin-1-C 35 kDa]: Mitochondrion {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}. Nucleus {ECO:0000269|PubMed:19713971}. Cytoplasm {ECO:0000269|PubMed:19713971}.; SUBCELLULAR LOCATION: [Beclin-1-C 37 kDa]: Mitochondrion {ECO:0000250|UniProtKB:O88597}.
Interaction partners:
- Vacuole membrane protein 1
- RB1-inducible coiled-coil protein 1
- Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
- Bcl-2-like protein 1
- Serine/threonine-protein kinase ULK1
- Apoptosis regulator Bcl-2
- High mobility group protein B1
- Phosphoinositide 3-kinase regulatory subunit 4
- Activating molecule in BECN1-regulated autophagy protein 1
- Nuclear receptor-binding factor 2
Sequence:
MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEEETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
Protein: Mitochondrial import protein 2 (Q3E798)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the MIM complex required for outer membrane protein import. Involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including UGO1, TOM20 and FZO1.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:22467864}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial import protein 1
- Vacuolar protein sorting-associated protein IST1
- Vacuolar protein-sorting-associated protein 46
- Vacuolar protein sorting-associated protein VTA1
- Vacuolar protein sorting-associated protein 20
- DOA4-independent degradation protein 4
- Vacuolar protein-sorting-associated protein 24
- Vacuolar-sorting protein BRO1
- Vacuolar protein-sorting-associated protein 60
- Mitochondrial import receptor subunit TOM70
Sequence:
MADSEDTSVILQGIDTINSVEGLEEDGYLSDEDTSLSNELADAQRQWEESLQQLNKLLNWVLLPLLGKYIGRRMAKTLWSRFIEHFV
Protein: Glycine decarboxylase (D4A5Q9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MQLCARAWGLRLGPGAGGGHRLARGTGLSWAPRSRDSSSGGGGGGGDRGAAGASRLLERLLPRHDDFARRHIGPGDKDRREMLQALGLASIDELIEKTVPASIRLKRPLKLEDPVCENEILETLHAIASKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRYRGVIVELKLPHEMDFSGKDVSGVLFQYPDTEGKVEDFTELVERAHQTGSLTCCATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLQHIAKRVHNATLILSEGLKRAGHQLQHDLFFDTLKVQCGCSLKEVLGRAAQRQINFRLFDDGTLGISLDETVTEKDLDDLLWIFGCESSTELVAEGMGEEWRGLLGSSFKRTSPFLTHQVFNSYHSETNLVRYMKKLENKDISLVHSMIPLPITWREFANIHPFVPLDQAQGYQQLFQELEKDLCELTGYDRVSFQPNSGAQGEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAYMAGMKIQPVEVDRYGNIDVAHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCALIHQHGGQVYLDGANMNAQMMGGKGLKEATEIAILNANYMAKRLERYYRVLFRGYVAHEFILDTRPFKKSANIEAVDVAKRLQDYGTLMIEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSRWDRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS
Protein: Protein odd-skipped-related 2 (Q8N2R0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein MSX-1
- Forkhead box protein L2
- Paired box protein Pax-9
- Pituitary homeobox 2
Sequence:
MGSKALPAPIPLHPSLQLTNYSFLQAVNTFPATVDHLQGLYGLSAVQTMHMNHWTLGYPNVHEITRSTITEMAAAQGLVDARFPFPALPFTTHLFHPKQGAIAHVLPALHKDRPRFDFANLAVAATQEDPPKMGDLSKLSPGLGSPISGLSKLTPDRKPSRGRLPSKTKKEFICKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHMQESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLRRHSLTHTPRQDF
Protein: Tachykinin-like peptide-XII (P.nigriventer tachykinin peptides XII) (PnTkP-XII) (U29-ctenitoxin-Pn1l) (U29-CNTX-Pn1l) (P86309)
Organism: Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Subcellular location: Secreted {ECO:0000269|PubMed:15573368}.
Interaction partners:
Sequence:
QKKDKKDKFYGLF
Protein: Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Q3TVW5)
Organism: Mus musculus (Mouse)
Function: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BT92}. Cytoplasm {ECO:0000250|UniProtKB:Q9BT92}. Cell membrane {ECO:0000250|UniProtKB:Q9BT92}. Mitochondrion {ECO:0000250|UniProtKB:Q9BT92}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9BT92}.
Interaction partners:
- Centrosomal protein of 164 kDa
- Outer dense fiber protein 2
- Ninein
- Centromere protein F
- Centrosomal protein of 89 kDa
- Mitofusin-2
- Fas-binding factor 1
- Centrosomal protein of 83 kDa
- Cilium assembly protein DZIP1
- Lysosomal enzyme trafficking factor
Sequence:
MALPTLPSYWSSRKHMDLRQRQHQQEDQFRQQWEQNSRYFRTWDIHNSKQIEWSSKISYQRSMHAYHCEKMKEEKRKILELRRERLRELLLEEQDLLAAELDELRLSMGLREQRLREQHQDLKSAREEQRKLIAERLLYEHWKKNNPKLRELELDLHKKHVINSWATQKEEKKQQEATEKQENKRLENQYAAARREAEARMRVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQLNRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAELQQLLREEAKEMWEKREAEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELEAQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPKLHGHLRIAWD
Protein: Protein UIP5 (ULP1-interacting protein 5) (P36137)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus membrane; Single-pass type I membrane protein.
Interaction partners:
- Uncharacterized protein YIL067C
- Vacuolar membrane protein YOR292C
- Uncharacterized vacuolar membrane protein YNL115C
- PMA1 stabilization in the Golgi protein 1
- Divalent cation/proton antiporter GDT1
Sequence:
MSRDVRAEKLAISLLILSLFLIFQLVAEIYLNNGDQYHTETSPFTRGRSHVTRVPNHDASLSIPFLDKINQFWHVGGATQIRNIQSIKLTQDRDQDKHGLVLSNGIGDNTINDFEIVFTFRISHDPTTQLTGDGMCFAITPENGFLTQNLQSSYAKKQYMMNSQGVIADNTDLMGFPKNLPGLFIVLDTYRNQGHDHKEVPFMDVFINVAPESDWYDINSDGELSTSLRLNSRGHIKLKKNALWNRVTKLRIIYLESISFLKIDVQYAKEGNYWIELFQTTENLYLPKNMHTGQRYIGCSALNGQLTETVELLDVSTSEFHWNDMDASIEDTYDYAKEAELFLEQEFGEVLDREPDEFTKWKMIKAQPNIKTGSQSAEQKTSNNPHSRLFKVVLTIWHYSEILLLIMGIYLFSACIRVFQRRFKKIRSRRKRAGSHSVGLLPM
Protein: Thymidine kinase (EC 2.7.1.21) (Q5I0A2)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Interaction partners:
Sequence:
MNCLNVPEIMPGSPSKSRGQIQVIFGPMFSGKSTELMRRVRRFQIAQYKCMLIKYAKDTRYSKEHLATHDQNTMAAVSACQLRDVSAEALACSVIGIDEGQFFPDIVDFCEEMANRGKTMIVAALDGTFQRKAFGNILNLVPLAESVVKLNSVCMECYREAAYTKRLGAEKEVEVIGGAEKYHSVCRLCFFKNQQLPVEKENVLSHNALDTISLKLSNKLQTACSPRKPLAQRQCL
Protein: Glyceraldehyde-3-phosphate dehydrogenase, cytosolic (GAPDH) (EC 1.2.1.12) (P10097)
Organism: Trypanosoma brucei brucei
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MVIRVGINGFGRIGRVVFRAAQRRNDIEIVGINDLLDADYMAYMLKYDSTHGRFEGAVEVQGGALVVNGKKIRVTSERDPANLKWNEINVDVVVESTGLFLSDDTARKHIQAGAKKVVITGPSKDDTPMFVMGVNHTTYKGEAIVSNASCTTNCLAPLAKVLNDKFGIVEGLMTTVHATTATQKTVDGPSQKDWRGGRGAAQNIIPSSTGAAKAVGKIIPSLNGKLTGMAFRVPTPNVSVVDLTVRLERPATYKQICDAIKAASEGELKGILGYVDEEIVSSDINGIPLTSVFDARAGISLNDNFVKLVSWYDNETGYSNKVHDLIAHITK
Protein: Spc105-related, isoform A (Q9VPB2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVDLLFLQLRKVPTKEDEATTTTSAIKQQIKRRISFSGKKSVREFVNTKETNNWDDSYEVSEHHAEDSSGSKCCSTGSASVARVSEHADKENIPLPSHCEREHVDLSVNLQASVDFTLLPCEMMDKSRKTSSISAVSFCMTSEERKLLQSSLSDRQLVDKTMDLISGSLVNRHQIASSVCEESSIKVATNKLEKVVFTPAVKAVSDSFMDITPLGFTDPNPAAPAPAPVATLYPPTQQSLMELEEDSIVREMRESTKNQTKTPAQKSLFMDVGETKNKTQQGAGGASFSLNVSNNRDRSPSNSFESLNSTMNFTRDESMLIPFDMISGKNISKKLNFRQLNEDLETGKIQIFPNGPKTPTTDRKAKKNRFWCGLEEESAGDNSPKKDIRSIVPRGMLNFSENMTLTPTKTSPVGKNKEKLKAADEKQKYRLSQADEMMLDNTNFLAHARLGDETQSRNTSKNSTRRETTCETSELNLEYPTLSQDFQPIPSSKTRKTDFMAEEMQLSQTNYPAIPALKTATSRRTLHLNESMDHETTKSTYVRKEISVTTQETIYEKSTTNEQNSNQNRNTWACTKTKRRATLLMQESMEEDIISPLKNLQLKPNAAPMNTGQSKVNHTLYLAEPLEEVDINQSNMLPTKNVAPREQLKARKTLLLEEPMEEEMSSNIGYNSKRKTLHLAEPLVVEGEDFILEKHIPIKVVAHQENKSKGRQTLLFEEPVEEEIFHNAKDLPECALKGNKTGPQKYSQLNQGKSFTSQSRSKARQTLLIEEPMEEDTEFNNKYNIAKPGENHIRKIAKSRQTLLLSEPLEEEMCLPPPKNKSIVSQKTIDKSTEQQRSKSRHTLLLSEPIEEEHIQQDLPAEKEDSLARQQRFKPRQTLIMAEPIEEDVGETERRVQTNITGSSTSRPRHTLLMSEPIEEELTNEDKSTNASTNRTLRSRRTILMAEPIEEEGNKSIAEKIGQFTKESSEEAVFQTSKSRQTLLMAEPIEEDVFNQSNDQPKPLPISKDKITRKTSRRHTLITAEPIEEDLSVRKPLENSKESSLTARIIQSFAEPIENALFSITDQIAKQQFSESVQTPPKEPLNYLHQKPRNTLISHETIQEDLEPVNENSSVGPLRSRYRKTLIMAEPIEEDVNNHNMTKQNGICDSLNVPQSGGYMAAKTRQSVHIPVPIEEDHIPGQQQRESEPAVKGRTTLLTESIEEDVPAQHTRISKNKSMGSKVSAEPIIEDLDSNRPEISQSVEETLPQRSQVPDVPSSRRHTLLLSEPMEEDEGIFGHNYPIRTKHQISEKLEKPEGPIHSSKNSVENEEIGTPPSAKTQQSIAMSESMDFQSPQFRPRGPDFNAITPGMSLTEFVDQEEMCKTPIHKRVLLTSHRKKLSMYQPVPIDLEANASGFGTPKNLVQLKRLPTHLTPNLPESKKRNTHLFPNSNMDIELEEDQEGSWGTKSIQMHTGTSKSRRTYTVDQLDASVQPVRDYNPVVTEMNKQGGLNMLELPRKSTYNMDLEEKPITISDVNNYFHEQKEQQRQSSERESGSSNDRTFKSYAATISKFINLTGNTTIFAAAEDLGGEGKDQPHQIDNEHLSLVSTLAEETDDDGDEKEEEEEQKQKQHLLQPEICEAQLNSMVKAGSEGSCKKCRNCNHTLSETRLSSESFVLPPRKLWDFSRLQQRLRNIRQRPSWKEVNTYWEIEEEARLSRNQDSDDSMEQTRVEEEATKWNKAALLEMCKLRTEEKDIAMPPESFFTRLKRLLTEQQPNWIFDYQRKVSQQMIFYNRQLTTIRIVVNYQIEDLVEESTISVCSIQLDNDVPTPKDQWSSREHFLNFHLSLRLPMNPSDEIEGSDETAFLKFLNGIDRRIAEVKQKLHKVLDLLAQKRARLTREANRTIVRKIVRKCIDQEPIVRLEKITFLIEIGNIEDVSFTDILRPELHLFNENIQYLPKGIPFLEAFLTDPEQYLRK
Protein: Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) (Q7Z7H5)
Organism: Homo sapiens (Human)
Function: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Transmembrane emp24 domain-containing protein 10
- Transmembrane emp24 domain-containing protein 2
- Transmembrane emp24 domain-containing protein 3
- Transmembrane emp24 domain-containing protein 5
- Alpha-N-acetylglucosaminidase
- Golgi reassembly-stacking protein 2
Sequence:
MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
Protein: AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase (F5GZZ0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGLT
Protein: VQ motif-containing protein 22 (AtVQ22) (Q9LIE6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as positive regulator of plant growth.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9M9F0}.
Interaction partners:
- Sigma factor binding protein 1, chloroplastic
- Calmodulin-binding protein 25
- VQ motif-containing protein 8, chloroplastic
- VQ motif-containing protein 29
- VQ motif-containing protein 17
- Sigma factor binding protein 2, chloroplastic
- Protein HAIKU1
- VQ motif-containing protein 18
- VQ motif-containing protein 10
- VQ motif-containing protein 9
Sequence:
MANPNEWSQFYNNNQTFFTTSTTASTAVTTTTAGDTTSIDSRLSPETGRVTKPTRRRSRASRRTPTTLLNTDTSNFRAMVQQYTGGPSAMAFGSGNTTSAFSLTSSSDPSAGSSQQAPWQYNFQPHAPLQPPQRPYMFSLNNVNPVVGYSNMNNPNTMVSGVFGTVDGSGGGGSAPSSKEATNSNSSSSRLQ
Protein: Histone H2B.1 (HTB1) (Q9LQQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H2A.6
- Probable histone H2A.3
- Histone H4
- Histone H3.1
- E3 ubiquitin-protein ligase BRE1-like 1
- E3 ubiquitin-protein ligase BRE1-like 2
- Histone H3.3
- Histone H3-like centromeric protein CENH3
- Histone H3-like 5
- Histone H3-like 3
Sequence:
MAPRAEKKPAEKKTAAERPVEENKAAEKAPAEKKPKAGKKLPPKEAGDKKKKRSKKNVETYKIYIFKVLKQVHPDIGISSKAMGIMNSFINDIFEKLAQESSKLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSS
Protein: IP14615p (Salivary gland-expressed bHLH, isoform A) (Salivary gland-expressed bHLH, isoform C) (Q9VHG3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTDQLLSSTAGVPGDPPPVLVPVSATTGGPYLSGGSEGEAESSEQPVLLELGAPQSSSCPAVSLNYTLTADGAGLLAYAPTHPHSYSPSVMGGYEKEAHNMGLLPPTYSVIPQPVSMWHAGQVATGSPVGLECNKPSELVPPPMYMSYSGGSIANSTEVDIAKEHNPAWREKALQMEKDYRRTACDRERTRMRDMNRAFDLLRSKLPISKPNGKKYSKIESLRIAINYINHLQAMLRESSVGQNGNGCCAWSGGSSSPYDNGNDHWGA
Protein: Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (Q62696)
Organism: Rattus norvegicus (Rat)
Function: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19213956}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q12959}. Basolateral cell membrane {ECO:0000269|PubMed:11865057}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10629225, ECO:0000269|PubMed:15044483}. Postsynaptic density {ECO:0000269|PubMed:15044483}. Synapse {ECO:0000269|PubMed:10629225}. Cell membrane, sarcolemma {ECO:0000269|PubMed:19213956}. Cell junction {ECO:0000269|PubMed:17980554}. Cytoplasm {ECO:0000250|UniProtKB:Q12959}. Apical cell membrane {ECO:0000250|UniProtKB:Q12959}. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells (PubMed:11865057). May also associate with endoplasmic reticulum membranes (PubMed:10629225, PubMed:15044483). Mainly found in neurons soma, moderately found at postsynaptic densities (PubMed:15044483). {ECO:0000250|UniProtKB:Q12959, ECO:0000269|PubMed:10629225, ECO:0000269|PubMed:11865057, ECO:0000269|PubMed:15044483}.
Interaction partners:
- Glutamate receptor 1
- Disks large homolog 4
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 2A
- Disks large homolog 2
- Peripheral plasma membrane protein CASK
- Disks large homolog 3
- Mitogen-activated protein kinase 12
- LLGL scribble cell polarity complex component 2
Sequence:
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVISIFQSNLFQALIDIQEFYEVTLLDNPKCVDHSKQCEPVQPGNPWESGSLSSAAVTSESLPGGLSPPVEKYRYQDEEVLPSERISPQVPNEVLGPELVHVSEKSLSEIENVHGFVSHSHISPIKPTEAVPPSSPIVPVTPALPVPAESPVVLPSTPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRKAFRKNHEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEAVTALKNTSDFVYLKAAKPTSMYINDGYAPPDITNSSSQSVDNHVSPSSYLGQTPASPARYSPISKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLRETMMNSSVSSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRGDKGEIPDDMGSKGLKHVTSNASDSESSYHEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRAVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTDEQARKTFERAVRLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGPYIWVPAKEKL