wanglab/gogpt-training-data huggingface dataset:
Protein: Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) (P35822)
Organism: Mus musculus (Mouse)
Function: Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Epidermal growth factor receptor
Sequence:
MDVAAAALPAFVALWLLYPWPLLGSALGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMVVDSSNHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESRADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLEPNGIITQYEVSYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPSLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEQLHPHRTKREAGAMECYQVPVTYQNALSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYKGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVIVIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRLPNDPLVPTAVLDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS
Protein: DNA mismatch repair protein PMS1 (Postmeiotic segregation protein 1) (Protein POSTMEIOTIC SEGREGATION 1) (Q941I6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates. Does not seem to be required for homologous somatic recombination.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA mismatch repair protein MLH1
- DNA mismatch repair protein MSH6
- DNA mismatch repair protein MSH2
- DNA mismatch repair protein MSH7
- DNA mismatch repair protein MSH5
- DNA mismatch repair protein MSH3
- DNA mismatch repair protein MSH1, mitochondrial
- Exonuclease 1
- DNA mismatch repair protein MSH4
- Exonuclease 1
Sequence:
MQGDSSPSPTTTSSPLIRPINRNVIHRICSGQVILDLSSAVKELVENSLDAGATSIEINLRDYGEDYFQVIDNGCGISPTNFKVLALKHHTSKLEDFTDLLNLTTYGFRGEALSSLCALGNLTVETRTKNEPVATLLTFDHSGLLTAEKKTARQIGTTVTVRKLFSNLPVRSKEFKRNIRKEYGKLVSLLNAYALIAKGVRFVCSNTTGKNPKSVVLNTQGRGSLKDNIITVFGISTFTSLQPVSICVSEDCRVEGFLSKPGQGTGRNLADRQYFFINGRPVDMPKVSKLVNELYKDTSSRKYPVTILDFIVPGGACDLNVTPDKRKVFFSDETSVIGSLREGLNEIYSSSNASYIVNRFEENSEQPDKAGVSSFQKKSNLLSEGIVLDVSSKTRLGEAIEKENPSLREVEIDNSSPMEKFKFEIKACGTKKGEGSLSVHDVTHLDKTPSKGLPQLNVTEKVTDASKDLSSRSSFAQSTLNTFVTMGKRKHENISTILSETPVLRNQTSSYRVEKSKFEVRALASRCLVEGDQLDDMVISKEDMTPSERDSELGNRISPGTQADNVERHEREHEKPIRFEEPTSDNTLTKGDVERVSEDNPRCSQPLRSVATVLDSPAQSTGPKMFSTLEFSFQNLRTRRLERLSRLQSTGYVSKCMNTPQPKKCFAAATLELSQPDDEERKARALAAATSELERLFRKEDFRRMQVLGQFNLGFIIAKLERDLFIVDQHAADEKFNFEHLARSTVLNQQPLLQPLNLELSPEEEVTVLMHMDIIRENGFLLEENPSAPPGKHFRLRAIPYSKNITFGVEDLKDLISTLGDNHGECSVASSYKTSKTDSICPSRVRAMLASRACRSSVMIGDPLRKNEMQKIVEHLADLESPWNCPHGRPTMRHLVDLTTLLTLPDDDNVNDDDDDDATISLA
Protein: Ecdysone-induced protein 63E, isoform F (EC 2.7.11.22) (Ecdysone-induced protein 63E, isoform M) (Serine/threonine protein kinase variant L63A2) (Q7KM08)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MATTTTTTTTTGATNAKDGVTMREKKGGALQKLKKRLSHSFGRLTISREDGDESTHHHHHHHHHRGGHGGHHNHGNKVPYNGYNSEEYLDRLEPNGNIPADKTNCRYGDWRSTDSTDHHDRVQRQLSVSSDSKLLDEDIREEMKYHSHVVMRPKKPPRPKSEVFLNKQETHPRRKRFSAFGGDSPFGKQEAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELPDETSIFTVEGVQLYTEPNRQNK
Protein: Root phototropism protein 2 (BTB/POZ domain-containing protein RPT2) (Q682S0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Signal transducer of the phototropic response and photo-induced movements. Necessary for root phototropism. Involved in hypocotyl phototropism under high rate but not under low rate light. Regulates stomata opening. Seems to be not involved in chloroplast accumulation and translocation.
Interaction partners:
- Phototropin-1
- Phototropin-2
- J domain-containing protein required for chloroplast accumulation response 1
- Protein PHYTOCHROME KINASE SUBSTRATE 1
- Protein PHYTOCHROME KINASE SUBSTRATE 4
- At2g30880/F7F1.9
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome regulatory subunit 4 homolog B
- Cullin-3B
- Cullin-3A
Sequence:
MATEGKNPINMNSMSSSLARTGQWVFSQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSDVTRINLSDIPGGPEIFEKAAKFCYGVNFEITVQNVAALHCAAEFLQMTDKYCDNNLAGRTQDFLSQVALSSLSGAIVVLKSCEILLPISRDLGIVRRCVDVVGAKACNEAMFPCRTPPNWWTEELCILDVDFFSDVVSSMKQRGVKPSSLASAIITYTEKSLRDLVRDHSGRGVKYSDPGDNESDERSQQRDLVQSIVSLLPSDKGLFPVNFLCSLLRCAVFLDTSLTCKNELEKRISVVLEHVSVDDLLIPSFTYDGERLLDLDSVRRIISAFVEKEKNVGVFNGGDFNRGVCSVSLQRVAKTVDSYLAEIATYGDLTISKFNAIANLVPKSARKSDDDLYRAIDIFLKAHPNLDEIEREKVCSSMDPLKLSYDARLHASQNKRLPVNIVLHALYYDQLKLRSGVAEQEERAVVVLPEALKTRSQLQADTTLAKENEALRSELMKMKMYVSDMQKNKNGAGASSSNSSSLVSSKKSKHTFFSSVSKKLGKLNPFKNGSKDTSHIDEDLGGVDITKPRRRRFSIS
Protein: Serine/threonine protein kinase, putative (EC 2.7.1.-) (D6XE12)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Association with the SNF1 complex
- Serine/threonine-protein phosphatase
Sequence:
MPEGEQAIGNYVIGKTIGKGSFGKVKEATHIPTGHTVAVKMINRDRLEHAKMDEKVAREIKILQLFSHPNICRLYEVIYTTTEIFLIMEYVECGELFQHIVNQGKLRENEARYIFQQIICAVNYCHNFLVAHRDLKPENILLGPGLQVKLIDFGLSNIAKDGEFLQTSCGSPNYAAPEVIDGRYYVGSNTDIWSCGVILYALLCGSLPFDESDTPSLFRKIKSGSYKIPAHVSSGARDLIEKILVVDPVHRLTIPQIYNHQWFVTNLPARLWPADPRRVDEQKRISTTAAAATAKYLNRSDREVRAAIREGRGEAFVAYSIIFDAEQRKILRNGADEILNKETTEMGCTTYGTELTHVPRATERELHLGLLLTQSPVMESLLGNGDVSSNKHAYNGSNFVPASMRETHHGAATAAATPPNPGGVFFIGKRADSYAETSGTLDSSYREDCGSTNPIDEARPGCSRDSKSRLSSGNTERQRVGSVAKSDVIYTREEREFIVKNNVGWRIGLMADLTSSGVMRVVYEVLKRYAMEWKSPTSFELLVRPTAVTFERIYNPLRETSSWDSAEDEGLQHTQQKRADRVLQVVILIHLFRIRESHDDGYILDFSVLKGSVIALDIVRCLFCTLVQKLA
Protein: Protein chibby homolog 1 (ARPP-binding protein) (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1) (Q9Y3M2)
Organism: Homo sapiens (Human)
Function: Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:16424001}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30395363}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27528616}. Golgi apparatus. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:16424001}.
Interaction partners:
- 14-3-3 protein zeta/delta
- Catenin beta-1
- CBY1-interacting BAR domain-containing protein 1
- Exportin-1
- Lymphoid enhancer-binding factor 1
- Cilium assembly protein DZIP1L
- Polycystin-2
- Cilium assembly protein DZIP1
Sequence:
MPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDMLSESTAESHLMEKELDELRISRKRK
Protein: Dihydroxyacetone phosphate acyltransferase (DAP-AT) (EC 2.3.1.42) (Glycerone-phosphate O-acyltransferase) (G1SPE9)
Organism: Oryctolagus cuniculus (Rabbit)
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:Q9ES71}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9ES71}; Matrix side {ECO:0000250|UniProtKB:Q9ES71}. Note=Exclusively localized to the lumenal side of the peroxisomal membrane. {ECO:0000250|UniProtKB:Q9ES71}.
Interaction partners:
- Alkylglycerone-phosphate synthase
- Fatty acyl-CoA reductase
- Glycerol-3-phosphate dehydrogenase [NAD
- Fatty acyl-CoA reductase
- Glycerol-3-phosphate dehydrogenase
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- Peroxisomal targeting signal 2 receptor
- Acyltransferase C-terminal domain-containing protein
- Diacylglycerol kinase
- phosphatidate phosphatase
Sequence:
MDSSSSSNYFSVGSTNPSAVVLLYSKELKKWDEFEDILEERRHVSDLKFAMKCYTPLVYKGITPCKPSDIKNSVLNSEEIHYVIKQLSMESLQSVDVLREEVCEILDEMSHKLRLGAIRFFAFALSKIFKQIFSKVCVNEEGIQKLQRAIQEHPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMKMIGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRNGYAPVEFFLEGTRSRSAKTLTPKFGLLSIVMEPFFKREVFDTYLVPISISYDKILEETLYAYELLGVPKPKESTTGLLKARRILSENFGSIYVYFGDPVSLRSLASGRMSRSPYNLVPRYIPQKQSEDMHAFVTEVAYKMQLLQIENLVLSPWPLIVAVLLQNRPSMDFDALLEKTLWLKGLTQAFGGFLIWPDNEPAEEVVQHHILLHSNIASLVKDQVILKLESGDSEVVDGLIFQHITLLTCSTYRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSAFRFLRDVFSDEFIFFPGNTVKDFEEGCYLLCKSETIQMTTRDILVTEKGNAVLEFLIGLFRPFVECYKLLCIYLLKEEEEHFTEKQYLAAVRKFTSQLLNQGASQCYDVLSSDVQKNALAAFVRLGVVEKKKVNNDYIFSVNEPATTKLEEMLGCKIPIGKPATAKL
Protein: Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (Q9UHP3)
Organism: Homo sapiens (Human)
Function: Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16501887, ECO:0000269|PubMed:19440361, ECO:0000269|PubMed:28619731}.; SUBCELLULAR LOCATION: [Isoform USP25m]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Some transient punctuate nuclear location in myotubes during myocyte development. {ECO:0000250}.
Interaction partners:
- Antiviral innate immune response receptor RIG-I
- Polyubiquitin-C
- Small ubiquitin-related modifier 2
- Small ubiquitin-related modifier 1
- Ubiquitin carboxyl-terminal hydrolase 13
- UV excision repair protein RAD23 homolog B
- Poly [ADP-ribose] polymerase tankyrase-2
- Tyrosine-protein kinase SYK
- Ubiquitin carboxyl-terminal hydrolase 5
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
Sequence:
MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSGSIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSAIKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNEFIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIKSFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR
Protein: Beta-sarcoglycan (Beta-SG) (43 kDa dystrophin-associated glycoprotein) (43DAG) (P82349)
Organism: Mus musculus (Mouse)
Function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular location: Cell membrane, sarcolemma {ECO:0000269|PubMed:9864373}; Single-pass type II membrane protein {ECO:0000269|PubMed:9864373}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9864373}.
Interaction partners:
- Alpha-sarcoglycan
- Delta-sarcoglycan
- Dystroglycan 1
- Gamma-sarcoglycan
- Dystrophin
- Utrophin
- Dystrobrevin alpha
- Sarcospan
- Zeta-sarcoglycan
- Phosphoglucomutase-like protein 5
Sequence:
MAAAAAAAAATEQQGSNGPVKKSMREKAVERRNVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIVLLFILAVINLLITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVEKNKTSITSDIGMQFFDPRTHNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGDVELKAENSIILNGTVMVSPTRLPSSSSGDQSGSGDWVRYKLCMCADGTLFKVQVTGHNMGCQVSDNPCGNTH
Protein: Arrestin C-terminal-like domain-containing protein (Q9XXI4)
Organism: Caenorhabditis elegans
Interaction partners:
- Arrestin C-terminal-like domain-containing protein
- Arrestin C-terminal-like domain-containing protein
- Arrestin C-terminal-like domain-containing protein
- Arrestin C-terminal-like domain-containing protein
- Protein ttm-2
- Arrestin C-terminal-like domain-containing protein
Sequence:
MDDLRIEYDAPNDVYFPGQAVTGKVIIQNREWIKARFLKICIHGGAHTHWSESRSTYRTNTRGERERFTENVNYNATINYLTGESIAWQSRDGTDRLPAGTNVFPFAFNLPINCAPSFEGCHGHIRYDVHVELDRPWKFNKKSRKCFSVIPVFDLNITPTAINPMVNTASKNTGLILKKGLVTITVNLPKRGYVAGEIMPITVNIDNGSKVAVSEVSAKMTQLSHFHASHGNMIGVTAHTHNRNDEKLVAESRRVADVPAKSRGQMVLSMKIPAIVPSFNCPIIAVDYCLTVKVSTQQIFGGGLKCEFPLIIGTIPIRQMNQAAPGAMPTMPSVSAPPYPVVAGASASQAVYPTAPSAPPASPGGEAPPSYEESVHGAGKVEDAEAFAPRYPVYNNLPQQQNSQLPPEYAPPLPAKSGF
Protein: ABPBG26 (Androgen binding protein gamma) (Salivary androgen-binding protein gamma subunit) (Secretoglobin, family 2B, member 26) (Q8JZX1)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Ribosomal RNA small subunit methyltransferase NEP1
- ABPA27
Sequence:
MKGTLLLLALLVIGELGFQTTEACLSFARTYGAILTLRRTFLHGDLSQFYATVAERVAFEKIQDCFREEGQKTIILNPQIMLSLYLSPECKKYYGNDLLKKIQDFLNQSNIH
Protein: Gamma-glutamyl peptidase 1 (EC 3.4.19.16) (Q9M0A7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in glucosinolate biosynthesis. Hydrolyzes the gamma-glutamyl peptide bond of several glutathione (GSH) conjugates to produce Cys-Gly conjugates related to glucosinolates. The gamma-Glu-Cys-Gly-GSH conjugates are the sulfur-donating molecule in glucosinolate biosynthesis. Converts phenylacetohydroximoyl-GSH to benzylglucosinolate. Can use the GSH conjugate of the camalexin intermediate IAN (GS-IAN) as substrate. Required for the biosynthesis of camalexin, a pathogen-inducible phytoalexin with antibacterial and antifungal properties.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:21712415}.
Interaction partners:
- S-alkyl-thiohydroximate lyase SUR1
- UDP-glycosyltransferase 74B1
- Cytosolic sulfotransferase 16
- Adenylyl-sulfate kinase 2, chloroplastic
- Cytosolic sulfotransferase 17
- Cytochrome P450 83B1
- Cytosolic sulfotransferase 18
- Tryptophan N-monooxygenase 1
- Inosine-5'-monophosphate dehydrogenase 2
- Inosine-5'-monophosphate dehydrogenase 1
Sequence:
MVEQKRYALFLATLDSEFVKKTYGGYHNVFVTTFGDEGEHWDSFRVVSGEFPDEKDLEKYDGFVISGSSHDAFENDDWILKLCDIVKKIDEMKKKILGICFGHQIIARVRGGTVGRAKKGPELKLGDITIVKDAITPGSYFGNEIPDSIAIIKCHQDEVLVLPETAKVLAYSKNYEVEMYSIEDHLFCIQGHPEYNKEILFEIVDRVLALGYVKQEFADAAKATMENRGADRKLWETICKNFLKGRVPTN
Protein: WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) (O75083)
Organism: Homo sapiens (Human)
Function: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27994071}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5RKI0}. Cell projection, podosome {ECO:0000269|PubMed:22721921}. Cell junction {ECO:0000269|PubMed:25792565}.
Interaction partners:
- Cofilin-1
- Cofilin-2
- F-actin-capping protein subunit beta
- Filamin-A
- Actin-related protein 3
- Adenylyl cyclase-associated protein 1
- Destrin
- Myosin-9
- Actin, cytoplasmic 2
- Talin-1
Sequence:
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (C9JXA2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTVT
Protein: Piwi domain-containing protein (Q27GU1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNQKQNPRLALNIFGLELSERTIFRHVVQMKLIDRQHNKEYILTTMSARGRGNRATKQKDNFILLDILLKQWAAKKGQQNLPAFAYDGAQSLFTLEGISLMVDIKKEDALEIPELSNFLKDSISFLSGDLEISCEPDLEKPSFVQTELNEWSDPRFYAYLDIVTSQSAIRSERYLSQSKGLYVHTQSLEELRVKWAVAAKGIHKGCRIVGANGPLPILELDPQSTQYYASIPLSQMLQYAFPRDFPPNRIVNPNMKLQRAVKLLLKDLKCNPYYDDKQIWATNTITVSDVDYNAPKDPEFRQKYPNLKFPMLPAVQCGTGPHKRLMPLEYLKVLPYQSIDRRVLEEFELTPRANAPNERWSTLQKHYDQFGFNDQVMKDFGVQICNDPFNNVSEIDGERVLAPSVAYADPVHVDDEKRDWKAQDKKFVTPATIDHLMFVLVAGYTRTWDADCDATKFVAKAFMQRCKDKGMHIGSYSMDQHNGERGSENFLTSVFKNLVTHPNYRDSSFTPFVLFISDDVPNIHECLKFEERMSDIPTQHVLLKNVKKMRDNIEKKSQGGRRAYDLTLDNIVMKANIKCGGLNYTADIPRDLACWNEVSTFVIGMDVAHPDRNAAREGNPSTVGLSCNSAENPYSFIGDFLYTDPRREAIQDEILRKFTDQSVRNFAEIRGFPKKVIIFRDGVSFGEETAALKEVEIIEQTIKTAAKSMGHSDYAPKVLAIVVKKRHHTRFYAKGGHHGNMPINPLPDTSVGGDIAEYGKRQIFIQAFRPVQGTAKVPSFLVIRDDEEVSDEHVAKMVCAVCSLHQLVNSPTSIPTPVYVAHELAKRGTGLYKAYRFKNGELFDDWETLTTQLSYSTLDRLSKVRVV
Protein: DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1) (O75190)
Organism: Homo sapiens (Human)
Function: Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10954706}. Nucleus {ECO:0000269|PubMed:10954706}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:22366786}.
Interaction partners:
- Heat shock cognate 71 kDa protein
- Heat shock 70 kDa protein 1A
- Heat shock 70 kDa protein 4
- BAG family molecular chaperone regulator 3
- E3 ubiquitin-protein ligase CHIP
- Stress-70 protein, mitochondrial
- Heat shock-related 70 kDa protein 2
- Myeloid leukemia factor 2
- GrpE protein homolog 1, mitochondrial
- Heat shock 70 kDa protein 6
Sequence:
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFEDPFEDFFGNRRGPRGSRSRGTGSFFSAFSGFPSFGSGFSSFDTGFTSFGSLGHGGLTSFSSTSFGGSGMGNFKSISTSTKMVNGRKITTKRIVENGQERVEVEEDGQLKSLTINGVADDDALAEERMRRGQNALPAQPAGLRPPKPPRPASLLRHAPHCLSEEEGEQDRPRAPGPWDPLASAAGLKEGGKRKKQKQREESKKKKSTKGNH
Protein: Toll-like receptor 22 (A0A2R8RTN4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Myeloid differentiation primary response protein MyD88
- TIR domain-containing adapter molecule 1
- TNF receptor-associated factor 6
- Interferon regulatory factor 3
Sequence:
MKRKSRESMGTLQQITVCITICAMVSPCSTFSLTNCTISSSQKDIKTQPKVLCYKMNFFTIPRVPNNTWILDISFNSFAQIQIEDLNILLNLQYLNVSNNKISKIQDGAFGSLFNLTDLNLASNRLNAVSNGMLRGLTNLLVLRLDRNYISVIKESAFSTLHSLQVLNLSKNHLRHIDDVKPVLASLYLEELYIGSNYFNVFNSSELSTKPLSLKRLDLSNNRFAAFQLTNNIFPTLNHLDLSYCGHNGTMAWNVTEKSYLASVKTLYFMDVNMSIQTADNVLQSFNNTLNKIRLNGNVRLNKTSLLLSVCSPMLRVLRLIATKIKHLTNHMFDPCSELSELDLGGNEISNLSQSMFRGFKQLKKLQLQINKLTRVTNSFQILTSLEFIDLSRNHIHKLSCNDFANLTQVKTLYLYSNKISSIRSCLFKDLKSLEVLRLGTNNLLKIDDVFSNGPYFLKELQLSYNKLSLIKSHTFGNLPQLNNLSLEDNQISEIEGYAFGGLENLTSLFLSSNKITGKTLTTHPNVFSGMPNLQNLDLFANSISFAYDKLKYPLFKDLKNLRELSLYSQRRGIGQLPSNLLEGLSSLQMFYIGNTNLNQLNPNLFNFTPQLWFLDLSKNALREDDAIPPELFHPIPNLTKLIISRTQLRSLNFLLGANLNKLSTLRASGNEIDSVNETLIKSLPRLAVLDLQNNTFTCDCNNAFFIDWAKKNESTQVYYLSRYTCSYPRTLRGTSLAEFNTDSCTFNWDYICFVCSSILVILTLLLSFIWNFLRYQVVYTYYLFLAFLYDSRRNQSGQTFQYDAFISYNTLDEAWVMEELIPKLEGEQGWRLCLHHRDFEPGRPIIDNIVDGIYSSRKTICLITRNYLKSNWCSSEVQVASFRLFDEQKDVLILVFLEDIPTHQLSPYHRLRKLVKKRTYIRWPKPGEDNKIFWQKLKMALETKDSHKSENCIL
Protein: Putative purine permease 9 (Q3ED99)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RING-H2 finger protein ATL60
- Oligopeptide transporter 1
- CTP synthase
- Oligopeptide transporter 6
- CTP synthase
- CTP synthase
- CTP synthase
Sequence:
MDKEIHQFGKGHVLHQMLRILELEVIQIMPKVMTNKKKPTLHIGV