wanglab/gogpt-training-data huggingface dataset:
Protein: Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) (Q9UQM7)
Organism: Homo sapiens (Human)
Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway. Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity).
Subcellular location: Synapse {ECO:0000250|UniProtKB:P11275}. Postsynaptic density {ECO:0000250|UniProtKB:P11275}. Cell projection, dendritic spine {ECO:0000269|PubMed:28130356}. Cell projection, dendrite {ECO:0000269|PubMed:28130356}. Note=Postsynaptic lipid rafts. {ECO:0000250|UniProtKB:P11275}.
Interaction partners:
- Calmodulin-like protein 5
- Calmodulin-like protein 3
- Calmodulin-like protein 6
- Glutamate receptor 1
- Calmodulin-1
- Calcium/calmodulin-dependent protein kinase type II subunit beta
- Glutamate receptor ionotropic, NMDA 2B
- Calmodulin-like protein 4
- Calcium/calmodulin-dependent protein kinase type II subunit delta
- Leucine-rich repeat-containing protein 7
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
Protein: Uncharacterized protein C17G8.12 (Q10324)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Exocyst complex component sec5
- Exocyst complex component sec10
- Exocyst complex component exo70
- Exocyst complex component sec6
- Exocyst complex component sec15
- Exocyst complex component exo84
- Exocyst complex component sec8
- Formin-3
- GTP-binding protein rho3
- Cell division control protein 42 homolog
Sequence:
MASNPNAVEQEILQAVNSAQTTDKRKAHEQSLAYLPVEEERGVNVVGSKMKPRYIALTCDDVTRIFYIHRLKVNDKGGMTVVKSWPLFELQNITVINDHDVTMTINKPHLLRTQDTSARDRFVFSVAKNYMYYMGRPLSVTTTDGRKVDWAYRNSFADNKPNLYPAKSLAIPKARSSLPENSSEQVSSSFNSRVAHNRNFSDGPIVTNLETDQPRIEKKLTIDSSRSAKKKLSVEKERRFSDNKPSSNVSRGTPSSAHSDVIEISSSSAIARTSGDRKDDVLFDTSTQRRDNQTREMFIQEQAQLFPSKPSLRKTTRREQAPSFNSGTSSSERGKNSISGSYEKNTALALEAGKYNMSQKDVKLSSSLESNTFASDFSKVDRDATQAALSSSLETPSVLTSSYKPSSSSKVSAKSVSRKPTGAPAIPKLPPKHPSRQPTVRATPSTGKQIEPPNDEPSIGNELLPLFESLRFENRKTTSKPKAKKTLVTSIPTKPHQASVEKVYDLNSKINLKNIPEQSISRLSTLKWNEGTTIKDVLKQTEFSFDGAIISSVENLAEEEIELQNIKSQLQDCALGCESINSTINLFSLELSTALNGVINIEQQPSRR
Protein: Large ribosomal subunit protein eL33x (60S ribosomal protein L35a-4) (P51422)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein eL42z/eL42y
- At1g43860
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein eL29y
- Large ribosomal subunit protein eL24z
- Large ribosomal subunit protein uL23z
Sequence:
MKGRQGERVRLYVRGTVLGYKRSKSNQYPNTSLVQIEGVNTQEEVNWYKGKRLAYIYKAKTKKNGSHYRCIWGKVTRPHGNSGVVRSKFTSNLPPKSMGARVRVFMYPSNI
Protein: Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) (Q8IUW3)
Organism: Homo sapiens (Human)
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase CYLD
- Sharpin
- E3 ubiquitin-protein ligase RNF31
- Spermatogenesis-associated protein 2
- RanBP-type and C3HC4-type zinc finger-containing protein 1
- VPS9 domain-containing protein 1
Sequence:
MGSSSLSEDYRQCLERELRRGRAGVCGDPSLRAVLWQILVEDFDLHGALQDDALALLTDGLWGRADLAPALRGLARAFELLELAAVHLYLLPWRKEFTTIKTFSGGYVHVLKGVLSDDLLLKSFQKMGYVRRDSHRLMVTALPPACQLVQVALGCFALRLECEILGEVLAQLGTSVLPAEELLQARRASGDVASCVAWLQQRLAQDEEPPPLPPRGSPAAYRAPLDLYRDLQEDEGSEDASLYGEPSPGPDSPPAELAYRPPLWEQSAKLWGTGGRAWEPPAEELPQASSPPYGALEEGLEPEPSAFSFLSLRRELSRPGDLATPESSAAASPRRIRAEGVPASAYRSVSEPPGYQAHSCLSPGALPTLCCDTCRQLHAAHCAALPACRPGHSLRVLLGDAQRRLWLQRAQMDTLLYNSPGARP
Protein: Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I) (P21816)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
Interaction partners:
- Cysteine sulfinic acid decarboxylase
- Cystathionine gamma-lyase
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Glutamate decarboxylase 1
- Glutamate decarboxylase 2
- Sulfite oxidase, mitochondrial
- Kynurenine--oxoglutarate transaminase 1
- Glutamate--cysteine ligase regulatory subunit
- Glutamate--cysteine ligase catalytic subunit
Sequence:
MERTELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNPAEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTPFTTSGSLENN
Protein: Tondu-domain-containing growth inhibitor, isoform A (Q9VU85)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Scalloped, isoform Q
- Transcriptional coactivator yorkie
- Protein interacting with Ttk69 and Sin3A, isoform D
- Scaffold protein salvador
Sequence:
MALRLDYRCLLDAFEDYYYHKEIQRLVAETAGGATATSPASSASSASSTASISSASCSSGPSTSSIVSSAASSHGSLAQVATARAAAALADQQALASQRAMFYNVQHPQQLEQLHALQAESGNQQMHPQANADPNASSMANSLLWQPWRDLQQAAAMHHQLYRQQQQQLQLHSEMRATSKVLTTTKWRRERRQRSAGYQPHEAGNSERERERERDREDRDMDSPIDMSVTTGALKQRASPPPPYREPLPGTNYAANSRPSVITQAPPKREPPEQAHSTDMAMCDIDEHFRRSLGENYAALFAKKSPTPTPTPTPSPSGTPKQQVSPLAYGLPSSTSTAASQHYQQQRSPLAKSGWVILEPESLQPELPPPQEEPLPLSLALHRTQTPPSPPPSATGSAPALPTAVSQVMEAAVAGRRILDTPHHTPPRYNTPPPPPPAYGIAGTTVVAPTLTPTPTPNPTPSQIPTPTPSMPAIIRVKAEPGLAAVAASSTQTPPASPTSSTNISIFTKTEASVDDHFAKALGETWKKLQGGHKE
Protein: Mitochondrial escape protein 2 (O94689)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- ATP-dependent zinc metalloprotease YME1 homolog
Sequence:
MNLFLSRFTGLRNTSFLGHARPFMFPRRYAHSLVAHNIGHIKLDPNEGLFFVDNLVNTPTYFYIQRYTALLFQNNLKKQLSAAFPSSDTMQLEDIIFRWQDGGAFLKVRYKEFPQDTEAVSEHVRESFRKRPVRTILHPFSTPIPHMVHGIPWLQDLYIFPSRTVDVNFEGPPLSQERLYSIFRTYGKLRSVTINSPTSATLSFSSLRSATSALNCMHGFVYGKTEFHMRYRHMNRFVAFKDWLFSHPRFTIPLVAAAITVLTASLFDPIRKFFVETNIVHGQKLRNINVVGWVKKKTRDIVLSPFHENGTNIKAPIWTTREKDCEQLKEWLDEALHSFIVVQGPRGSGKRDLVDRVVKERKNVLFFDCDRLFSTTNTEMFVSTLASQTGYFPLFSFLNNISSLIDMAAQGLIGQKTGIVSSSEGQVRQILNTTQTVLRSLALREHKEADTSVLDESEFLEVHADRLPVVILDNFQLRKLSNPMQRVVAEWAGNLVKEGIAHVLMLTPDVGGTKSLEQYVNGWENRTLLLGDADPVLAQRYVIESLPEEMQTEELRKELRVQLPKIGGRLRDLDYVARRLRVNSSSVSEAIGGIVSQNASDILQTFLRPASLTSEEKPTFTPEESWTLITYLSQHEYIPYHMLMLDPLFKGHDDAVRALEESELITITTVNARPDKVYAGKPVYVTAFRQLVNDPVLSANMQLVRCNALIGMANNAIKNDEQELQMLKDLGNLESGVKDRAHYLTTRIQKNQGVITDNEKSIERLTEALKKID
Protein: Factor H binding protein (fHbp) (Genome-derived Neisseria antigen 1870) (GNA1870) (Lipoprotein 2086) (LP2086) (Q9JXV4)
Organism: Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
Function: A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties. fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice.
Subcellular location: Cell outer membrane {ECO:0000305|PubMed:12642606}; Lipid-anchor {ECO:0000305|PubMed:12642606}. Secreted {ECO:0000269|PubMed:12642606}. Extracellular vesicle, bacterial extracellular vesicle {ECO:0000269|PubMed:12642606}. Note=Surface exposed on encapsulated and non-encapsulated strains. In freshly innoculated cells no secreted protein is seen, as cultures grow the amount of protein in the cell supernatant increases. {ECO:0000269|PubMed:12642606}.
Interaction partners:
- Fructose-1,6-bisphosphate aldolase
- Quinolinate synthase
Sequence:
MNRTAFCCLSLTTALILTACSSGGGGVAADIGAGLADALTAPLDHKDKGLQSLTLDQSVRKNEKLKLAAQGAEKTYGNGDSLNTGKLKNDKVSRFDFIRQIEVDGQLITLESGEFQVYKQSHSALTAFQTEQIQDSEHSGKMVAKRQFRIGDIAGEHTSFDKLPEGGRATYRGTAFGSDDAGGKLTYTIDFAAKQGNGKIEHLKSPELNVDLAAADIKPDGKRHAVISGSVLYNQAEKGSYSLGIFGGKAQEVAGSAEVKTVNGIRHIGLAAKQ
Protein: Transmembrane protein 252 (Q8N6L7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MQNRTGLILCALALLMGFLMVCLGAFFISWGSIFDCQGSLIAAYLLLPLGFVILLSGIFWSNYRQVTESKGVLRHMLRQHLAHGALPVATVDRPDFYPPAYEESLEVEKQSCPAEREASGIPPPLYTETGLEFQDGNDSHPEAPPSYRESIAGLVVTAISEDAQRRGQEC
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F4KGL1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MALLIITALVFSSLWSSVSPDAQGDALFALRSSLRASPEQLSDWNQNQVDPCTWSQVICDDKKHVTSVTLSYMNFSSGTLSSGIGILTTLKTLTLKGNGIMGGIPESIGNLSSLTSLDLEDNHLTDRIPSTLGNLKNLQFLTLSRNNLNGSIPDSLTGLSKLINILLDSNNLSGEIPQSLFKIPKYNFTANNLSCGGTFPQPCVTESSPSGDSSSRKTGIIAGVVSGIAVILLGFFFFFFCKDKHKGYKRDVFVDVAGEVDRRIAFGQLRRFAWRELQLATDEFSEKNVLGQGGFGKVYKGLLSDGTKVAVKRLTDFERPGGDEAFQREVEMISVAVHRNLLRLIGFCTTQTERLLVYPFMQNLSVAYCLREIKPGDPVLDWFRRKQIALGAARGLEYLHEHCNPKIIHRDVKAANVLLDEDFEAVVGDFGLAKLVDVRRTNVTTQVRGTMGHIAPECISTGKSSEKTDVFGYGIMLLELVTGQRAIDFSRLEEEDDVLLLDHVKKLEREKRLEDIVDKKLDEDYIKEEVEMMIQVALLCTQAAPEERPAMSEVVRMLEGEGLAERWEEWQNLEVTRQEEFQRLQRRFDWGEDSINNQDAIELSGSSSLSVVFLVFTLSRVIQTVDVCDYINTDQQNQKL
Protein: Amine oxidase (EC 1.4.3.-) (B1ARV3)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- S-adenosylmethionine synthase isoform type-2
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Phenylalanine-4-hydroxylase
- Branched-chain-amino-acid aminotransferase, mitochondrial
- Tyrosinase
- Tyrosine aminotransferase
- Branched-chain-amino-acid aminotransferase, cytosolic
- Aromatic-L-amino-acid decarboxylase
- L-amino-acid oxidase
Sequence:
MSFRTMAKKSGILVWGILLCVSSCLALYENLVKCFQDPDYEAFLLIAQNGLHTSPLSKRVVVVGAGMAGLVAAKTLQDAGHEVTILEASNHIGGRVVTLRNKEEGWYLELGPMRIPESHKLIHTYVQKLGLKLNKFHQYDSNTWYLLNGQRYRASEVMANPGILGYPLRPSEKNKTVTDLFYQAITKIKPHRKTSNCSQLLSLYDSYSTKAYLMKEGTLSKGAIEMIGDIMNENAGYYKSLLESLRIASIFSKSDQFSEITGGFDQLPNGLSASLKPGTIRLGSKVERVVRDGPKVKVMYRTDGPTSALHKLTADYAIITASAKATRLITFQPPLSREKTHALRSVHYTSATKVVLVCNERFWEQDGIRGGYSITDRPSRFIYYPSHSLPGGKGVLLASFTVGDDSSFFAALKPNQVVDVVLDDLAAVHRIPKEELKRMCPKSAIKHWSLDPLTIGAFTEFTPYQFVDYSKQLSQPEGRIYFAGEHTCLPHSWIDTAIKSGIRASCNIQAAVDKEATRGHTAL
Protein: Dihydropyrimidinase 2 (EC 3.5.2.2) (CeCRMP/DHP-2) (UlipA) (Q18677)
Organism: Caenorhabditis elegans
Interaction partners:
- Dihydropyrimidine dehydrogenase [NADP
- Beta-ureidopropionase
- Multifunctional protein pyr-1
- Probable Golgi transport protein 1
- Dihydropyrimidinase 1
- Dihydroorotate dehydrogenase
- Carrier protein
- Trifunctional purine biosynthetic protein adenosine-3
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Cytochrome-b5 reductase
Sequence:
MSLLIKNGTIVNDDAIFKSDVLVLDGRIVEIAPSIQPTPGLEVVDATDRLVIPGGIDPHTHMQLPFMGEIAKDDFHRGTEAAVAGGTTMIIDFVIPTKGESLLVAYDRWRGWADPKVVCDYGLSMAITSWGPEIAKEMEIVTGAEYGINSFKFFLAYAGVFMVRDEEFYQGMIQCAKLRALARVHAENGSVIAERCEHLLSSGITGPEGHTQSRPEELEAEATFRACTMASQANCPLYVVHVMSKGAAAAIAHHRKKGAVVFGEPIAAGLATDGSHYYNEDWLHAARYVMSPPLSRDPSTPSALMKLLAAGELHLTATDNCTFDCQQKSLGKDDFTKIPNGVNGVEDRMSVVWDKGVHAGIIDPMRFVAVTSTMAAKIFNCYPQKGRIAVGSDADIVIWNANATRTISKDTHHHAIDFNIFEGMQVHGVPEITISRGRTVWANGQLKTVQGSGQFIPLAPDSQIVFSAVDNRKKAMEPVKIDRIPYEPSALQTPDANANIVVKAPVRAAIPPGGASSIQF
Protein: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Fatty acid oxidation complex subunit beta) (P28790)
Organism: Pseudomonas fragi
Function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01620}.
Interaction partners:
- Fatty acid oxidation complex subunit alpha
- acyl-CoA dehydrogenase
- 3-oxoadipyl-CoA thiolase
- Methylmalonate-semialdehyde dehydrogenase
- Hypothetical protein
- Acyl dehydratase
- acyl-CoA dehydrogenase
- Acetyl-coenzyme A synthetase
- Citrate synthase
- 2-methylcitrate synthase
Sequence:
MSLNPRDVVIVDFGRTPMGRSKGGMHRNTRAEDMSAHLISKVLERNSKVDPGEVEDVIWGCVNQTLEQGWNIARMASLMTQIPHTSAAQTVSRLCGSSMSALHTAAQAIMTGNGDVFVVGGVEHMGHVSMMHGVDPNPHMSLYAAKASGMMGLTAEMLGKMHGISREQQDAFAVRSHQLAHKATVEGKFKDEIIPMQGYDENGFLKIFDYDETIRPDTTLESLAALKPAFNPKGGTVTAGTSSQITDGASCMIVMSAQRAKDLGLEPLAVIRSMAVAGVDPAIMGYGPVPATQKALKRAGLNMADIDFIELNEAFAAQALPVLKDLKVLDKMNEKVNLHGGAIALGHPFGCSGARISGTLLNVMKQNGGTFGLSTMCIGLGQGIATVFERV
Protein: T-complex protein 1 subunit beta (CCT-beta) (Q6PBW6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MASLSMAPVSIFKHGADEEKAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLGGGRESTVTVTNDGATILKAIGVDNPAAKVLVDMSKVQDDEVGDGTTSVTVLAAELLREAELLIAKKIHPQIIIAGWRKATQAARDALREAAVDHGSDEVKFQEDLLNISRTTLSSKLLTHHKDHFAKLAVQAVMRLRGSGNLEAIHLIKKLGGSLTDSYLDEGFLLDKRIGVNQPKRIENANILIANTGMDTDKIKIFGSRVRVDSTAKVAEIETAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFAAAGVMAIEHADFTGVERLALVTGGEITSTFDHPELVKLGHCKLIEEVMIGEDTLIHFSGVSMGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKETRTVYGGGCSEMLMAKAVSDLANHTPGKEAVAMESFAKALMMLPTIIADNAGYDSAELVSQLRAAHQDNKNTFGLDMTQGCVGDMSALGVTESFQVKRQVLLSAAEAAEMILRVDNIIKAAPRKRVPDHHPC
Protein: Leucine-rich repeat-containing protein 20 (Q8TCA0)
Organism: Homo sapiens (Human)
Interaction partners:
- Leucine-rich repeat-containing protein 30
Sequence:
MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGARAPLP
Protein: Torsin-like protein (O77277)
Organism: Drosophila melanogaster (Fruit fly)
Function: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250}.
Interaction partners:
- LD31235p
- Protein lap1
- phosphatidate phosphatase
- Muscle-specific protein 300 kDa, isoform G
- LD13476p
Sequence:
MMSFPRMLSLCLSVLVILPLPLQSVDPLTIGAVGAVALGAYFKEHTYCRFAECCDDRNIPARIDELERSLERTLIGQHIVRQHIVPALKAHIASGNKSRKPLVISFHGQPGTGKNFVAEQIADAMYLKGSRSNYVTKYLGQADFPKESEVSNYRVKINNAVRDTLRSCPRSLFIFDEVDKMPSGVFDQLTSLVDYNAFVDGTDNTKAIFIFLSNTAGSHIASHLGSVMKNGRLREDTRLSDFEPLLRKAAYNMDGGMKKTTMIESHVIDHFIPFLPMEKAHVIKCLEAELLRWRRDPKQANNQKIIEDIINSSISYDRTHSLFAISGCKTLEKKVAMAIY
Protein: Uncharacterized protein YhcF (P45422)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Putative nuclease YhcG
- UPF0056 membrane protein YhcE
- Uncharacterized fimbrial chaperone YhcA
- Uncharacterized outer membrane usher protein YhcD
- Uncharacterized protein YigE
- Esterase YpfH
Sequence:
MNNVKLLIAGSAFFAMSAQAADRVSIDVKVTLEAAACTPILSNGGVVNFGSHSVNRLSTQHYTQIGTRNINMTITCESATGIAITARDTRMDSMTTGKDSGGQSGVKYTLNGGGYISQTTRLFGLGKTKDNKNIGSYAVLIDSNNISASNGSQTLAVSIAGADAVITGQKRAWQTLTAYPLAVDQSYYYTFVKPGETTPTPVTNAIIPLQVSASIANDLGGSEKIELDGKAVISVVYL
Protein: Translocase outer membrane 20-1 (F4JEW8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004572}.
Interaction partners:
Sequence:
MDKLNFFEEIRKDAEETYKLNPEDADVSFYLRFLIFRYCFASFSFVLCSIFRGMTLPWFDFCFCNQWRELKNFLALSLTLYVFFAEFDEMGRSFTRVISVSKRYRFTENDSRYAISKLEDAILIDPMKHDAVWCLGNAYTSYARLTPDDTQARLNFGLAYLFFGIAVAQQPDNQVYHKSLEMADKAPQLHTGFHKNRLLSLLGGVETLAIPSPKVVKNKKSSDEKYIVMGWVILAIGVVACISFRKLR
Protein: Transcription factor nsy-7 (Neuronal symmetry protein 7) (H2KYW5)
Organism: Caenorhabditis elegans
Function: Transcriptional regulator which binds DNA consensus sequence 5'-CCTTAAC-3'. Plays a role in establishing and maintaining asymmetric cell fates in chemosensory AWC neurons during larval neuronal development. This is achieved by repressing the expression of multiple AWC (OFF) genes, including srsx-3 and hlh-11 in the AWC (ON) neuron. Activates expression of sox-2 in the AWC (ON) neuron.
Subcellular location: Nucleus {ECO:0000305|PubMed:19204119, ECO:0000305|PubMed:31767767}.
Interaction partners:
- Homeobox-containing protein 1
- Non-structural maintenance of chromosomes element 4
- Innexin-19
Sequence:
MSSDTKYKYAVVRIPETSVVDFFSLIVAKGYSDVSFVASLSQCNLRDDPNDDQPTTSSNSVKESINDDESNSENNKLSPPRRQSNPHSSLPAISSSTVKNEPTDSWTPSALSNDPTPDLLSATVPAELLTNLFAKTKSTEPKPQQLFGFQASGVDFDLSNNEWHENLRLPNGNGTEKYHPYGGNSKNDSPLQTRMKGWQREYIKEVIKDSHYPTEEELRDIEQKCDLSRKQILRFIAKRLTNPNRKPRVNHHDEKRKEQEERDSLADPDDDMINDNEAVTNLHHILNSLQETTA
Protein: Uncharacterized inner membrane transporter YhbE (P0AA73)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- GTPase ObgE/CgtA
Sequence:
MKQQAGIGILLALTTAICWGALPIAMKQVLEVMEPPTIVFYRFLMASIGLGAILAVKKRLPPLRVFRKPRWLILLAVATAGLFGNFILFSSSLQYLSPTASQVIGQLSPVGMMVASVFILKEKMRSTQVVGALMLLSGLVMFFNTSLVEIFTKLTDYTWGVIFGVGAATVWVSYGVAQKVLLRRLASPQILFLLYTLCTIALFPLAKPGVIAQLSHWQLACLIFCGLNTLVGYGALAEAMARWQAAQVSAIITLTPLFTLFFSDLLSLAWPDFFARPMLNLLGYLGAFVVVAGAMYSAIGHRIWGGLRKHTTVVSQPRAGE
Protein: Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB (EC 2.8.4.5) (tRNA-t(6)A37 methylthiotransferase) (P54462)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00780, ECO:0000269|PubMed:20584901}.
Interaction partners:
- Ribosomal protein L11 methyltransferase
- Ribosomal RNA small subunit methyltransferase E
- Chaperone protein DnaJ
- tRNA dimethylallyltransferase
- Putative cysteine desulfurase IscS 1
- Probable ribosomal RNA small subunit methyltransferase B
- tRNA threonylcarbamoyladenosine dehydratase
- Probable tRNA sulfurtransferase
- Probable dual-specificity RNA methyltransferase RlmN
Sequence:
MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVINTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDREKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFCIIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSELDTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYTMEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSKRTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEEENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLSS
Protein: Lens fiber major intrinsic protein (Aquaporin-0) (MIP26) (MP26) (P30301)
Organism: Homo sapiens (Human)
Function: Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11001937, ECO:0000269|PubMed:23116563, ECO:0000269|PubMed:24120416, ECO:0000269|PubMed:25946197, ECO:0000269|PubMed:30790544}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6J8I9}. Cell junction {ECO:0000250|UniProtKB:Q6J8I9}. Note=Localizes to thin cell-cell junctions in lens fiber cells. {ECO:0000250|UniProtKB:Q6J8I9}.
Interaction partners:
- Calmodulin-like protein 5
- Calmodulin-like protein 3
- Calmodulin-like protein 4
- Calmodulin-like protein 6
- Aquaporin-10
- Gap junction alpha-8 protein
- Putative aquaporin-12A
- Calmodulin-1
- Filensin
- Aquaporin-11
Sequence:
MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL
Protein: At5g18250 (Dbj|BAA90342.1) (Transmembrane protein) (Q9FK46)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTDSGHDIEIRCHHCAGPLTRNLETSKWTVDPFIRDSFSMIGSAVGGTASAFIGFNHAMPIVRKWIKGPMWLHFLVGAPPVIVLSSACAGLAGGTVPALAQLASSSYRAAVHSSQPPQAQKDNKMQKSTTSPL
Protein: Mitochondrial fission 1 protein (Mitochondrial division protein 2) (P40515)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation. Required for targeting MDV1 to the mitochondria. Regulates the assembly of DNM1 into punctate structures, in the mitochondrial tubules, promoting mitochondrial membrane constriction and/or division.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:11038183, ECO:0000269|PubMed:12514182, ECO:0000269|PubMed:14576278}; Single-pass membrane protein {ECO:0000269|PubMed:11038183, ECO:0000269|PubMed:12514182, ECO:0000269|PubMed:14576278}.
Interaction partners:
- Mitochondrial division protein 1
- CCR4-associated factor 4
- Dynamin-related protein DNM1
- Mitofusin FZO1
- Peroxisomal membrane protein PMP27
- Peroxisomal membrane protein import receptor PEX19
- Dynamin-like GTPase MGM1, mitochondrial
- Mitochondrial import receptor subunit TOM20
- Peroxisomal biogenesis factor 3
- Non-selective voltage-gated ion channel 1
Sequence:
MTKVDFWPTLKDAYEPLYPQQLEILRQQVVSEGGPTATIQSRFNYAWGLIKSTDVNDERLGVKILTDIYKEAESRRRECLYYLTIGCYKLGEYSMAKRYVDTLFEHERNNKQVGALKSMVEDKIQKETLKGVVVAGGVLAGAVAVASFFLRNKRR
Protein: STE20-related kinase adapter protein alpha (STE20-related adapter protein) (A0A1W2PPJ9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSFLVSKPERIRTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLVTNLEELEVDDWEF
Protein: Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) (H3BMQ2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVELCIKLLQVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPIKYQRELWNKTIDAMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDIKEVKQNIHLIRAPLAGKGKQLEEKMVQQLQEDVDMEDAP