wanglab/gogpt-training-data huggingface dataset:
Protein: Rac family small GTPase 1a (Rac1) (Ras-like protein Rac1a) (Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2)) (Q7ZSZ9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- IQ motif-containing GTPase-activating protein 1.
- Non-specific serine/threonine protein kinase.
- Rho guanine nucleotide exchange factor TIAM1 isoform X1
- Guanine nucleotide exchange factor VAV2 isoform X3
- Rho guanine nucleotide exchange factor
- IQ motif-containing GTPase-activating protein 2
- BAR/IMD domain-containing adaptor protein 2a.
- BAR/IMD domain-containing adaptor protein 2b.
- Si:ch73-383g2.1.
- Rho GTPase-activating protein 17
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKRRRRRCLLL
Protein: Beta-synuclein (Q91ZZ3)
Organism: Mus musculus (Mouse)
Function: May be involved in neuronal plasticity.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Alpha-synuclein
Sequence:
MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTSGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKKEEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDSPQEEYQEYEPEA
Protein: Protein Wnt-11 (P48615)
Organism: Mus musculus (Mouse)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Frizzled-6
- Frizzled-7
- Frizzled-3
- Tyrosine-protein kinase RYK
- Frizzled-8
- Frizzled-9
- Frizzled-4
- Frizzled-2
- Frizzled-1
- Frizzled-5
Sequence:
MRARPQVCEALLFALALHTGVCYGIKWLALSKTPAALALNQTQHCKQLEGLVSAQVQLCRSNLELMRTIVHAARGAMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAATISHTIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLETKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK
Protein: GH08370p (Q8MR64)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MQEMSYLQDNSKVEALTKAVLISILGVAIVLSNLLIIATYANFKGPTEVINYYLLSLAIADLLCGLLVVPFSVYPALTGEWMYGDIVCRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKTRCQCWMVFTWISAALLCCPPILGYSMPIENNMTHICMLDWGNMAAYSATLAILVLGPSLISIVHNYGYIFVMMRKIRSGEPIHDKEYATALAESLSNPGHMMSFALVFAFWVSWLPWILLRLYEVVTGDVIQSTLINFAVVWIGILNSFWKILIMTSMSPQFRIALRVFCLTICCKTKGRLQAELVGLDPDDWS
Protein: Succinyl-CoA:3-ketoacid-coenzyme A transferase (EC 2.8.3.5) (A0A024R040)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAVKDIPDGATVLVGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLLLRSKQIKRMVSSYVGENAEFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAETTVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYEKRIERLSIRKEGDGEAKSAKPGDDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNITVHLQSENGVLGLGPYPRQHEADADLINAGKETVTILPGASFFSSDESFAMIRGGHVDLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSAKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKAVFDVDKKKGLTLIELWEGLTVDDVQKSTGCDFAVSPKLMPMQQIAN
Protein: Blown fuse, isoform B (E1JGZ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIRGIEEHVHIYVRAHFRASLETSEYENTSNLFHVTAAEQTAALLARCEILLAAASSASGSGSGLELGSGLGCADEQAAANHRSSLVDCVDSKVGAETGPSGYLEMLASPSPSKSSLSASREYIDLGSSGSLDRCSVNQPVPAAKDKEPHQQLYEICQGQGAGQDEDEAQQAITFTHEVFIDCPYADLPAGHLSLQRSTKYGQLQRIVPKRLFFDQTRKCYCGILNDWMLCYADGPTACRPSSTLYLKSSSIEIEHFGEGKRRDICFQITTDDPNKKFVYQANNEVDAKEWIHAIEAAIRGDAGAHSALKTPPPRKLPTPPVQKKSTYTAADIIYEEPSPVYGLIDSSSMVLPKLPEKSNSPSALARRFEYDVPKCPAQPLQDTSSRVASVSGELESLGLLNEGDIKVQPQPSSLHGSISLDFQARVKTVHSELSTQLSAAGPSPDRLKKAAKKSYSNGSEPEMLSPLTSPVQTPTKDQKKQRKSTTSPQSSPVSKDCDKLARNWFLSRLNKSTGLKATNTGSASPTNAKCKQSEKENLLTEAELGEGYDASPGDRYHGLPGSPPTSPCLKAEAKSKVNMIINQFESSGHLSTMFSVEALAANALASLTSFCESDGCNNYEPIMPLATTPSSFLKKV
Protein: Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Plasma cell-specific thioredoxin-related protein) (PC-TRP) (Thioredoxin-like protein p46) (Q91W90)
Organism: Mus musculus (Mouse)
Function: Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12930873}.
Interaction partners:
- Peroxiredoxin-4
- ERO1-like protein beta
- ERO1-like protein alpha
- Alpha-soluble NSF attachment protein
- Dysbindin
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Protein disulfide-isomerase
Sequence:
MPPRPGRLLQPLAGLPALATLLLLLGARKGARAQEVEADSGVEQDPHAKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTADSDVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFETLENWMLQTLNEEPATPEPEAEPPRAPELKQGLYELSANNFELHVSQGNHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKKVDQYKGKRDLESLRDYVQSQLQGSEAAPETVEPSEAPVMAAEPTGDKGTVLALTEKSFEDTIAQGITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDVTIAEVDCTAERNVCSKYSVRGYPTLLLFRGGEKVGEHNGGRDLDSLHSFVLRQAKDEL
Protein: Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) (Q64487)
Organism: Mus musculus (Mouse)
Function: Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Interleukin-1 receptor accessory protein
- Interleukin-1 receptor accessory protein-like 1
- SLIT and NTRK-like protein 2
- Liprin-alpha-3
- Neuroligin-3
- SLIT and NTRK-like protein 1
- Leucine-rich repeat and fibronectin type-III domain-containing protein 5
- SLIT and NTRK-like protein 3
- X-linked interleukin-1 receptor accessory protein-like 2
- Ppfia1 protein,-interacting protein
Sequence:
MVPVARPLSLLLTFFLCACAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDGIATTRYSVAGLSPYSDYEFRVVAVNNIGRGPASEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIASYELVYRDGDQGEEQRITIEPGTSYRLQGLKPNSLYYFRLSARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSLKYAAVDGEDFKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTDEDVPSGPPRKVEVEAVNATAVKVSWRSPVPNKQHGQIRGYQVHYVKMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISVPEEIPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGVITKYTLLYRDINVPLLPMEHLIVPADTSMTLTGLKSDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPDVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMDHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESESRKSSLPNSKEVPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEYLGSFDHYAT
Protein: RNA helicase (EC 3.6.4.13) (Q8QGG8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDDWEEDQSPVVSCSSGFGLGSNGSDGGFKSFYTGGAGNDKSNSEGTEGSSWKMTGDSFRGRGGRGGSRGGRGGFSGFKSEIDENGSDGGWNGGESRGKGRGGFRGGFRSGSRDENDENGNDDGWKGGESRGRGRGGFGGGFRGGFRDGGNEDTGRRGFGRENNENGNDEGEGRGRGRGGFRGGFRDGGGDESGKRGFGRGGFRGRNEEVFSKVTTADKLDQEGSENAGPKVVYVPPPPPEEESSIFSHYATGINFDKYDDILVDVSGSNPPKAIMTFEEAGLCDSLSKNVSKSGYVKPTPVQKHGIPIISAGRDLMACAQTGSGKTAAFLLPILQRFMTDGVAASKFSEIQEPEAIIVAPTRELINQIYLEARKFAYGTCVRPVVVYGGINTGYTIREVLKGCNVLCATPGRLHDLIGRGKIGLSKVRYLVLDEADRMLDMGFEPEMRKLVASPGMPSKEERQTLMFSATYPEDIQRMAADFLKVDYIFLAVGVVGGACSDVEQTIVQVDQYSKRDQLLELLRATGNERTMVFVETKRSADFIATFLCQEKISTTSIHGDREQREREKALSDFRLGQCPVLVATSVAARGLDIEQVQHVVNFDMPSSIDEYVHRIGRTGRCGNTGRAVSFFNPESDTPLARSLVKVLSGAQQVVPKWLEEVAFSAHGTTGFNPRGKVFASTDSRKGGSFKSDEPPPSQTSAPSAAAAADDEEWE
Protein: L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Q9PVK5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Pyruvate kinase
- Pyruvate carboxylase
- Pyruvate kinase
- Fructose-bisphosphate aldolase
- Aspartate aminotransferase, mitochondrial
- Pyruvate kinase
- Aspartate aminotransferase.
- Pyruvate carboxylase
- Aspartate aminotransferase
- aspartate transaminase
Sequence:
MASTKEKLIAHVSKEQPAGPTNKVTVVGVGMVGMAAAVSILLKDLTDELALVDVMEDKLKGEAMDLQHGSLFLKTHKIVADKDYSVTANSKVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIIKYSPNCILLVVSNPVDILTYVAWKLSGLPRNRVIGSGTNLDSARFRYLMGEKLGIHPSSCHGWVVGEHGDSSVPVWSGVNVAGVSLQALNPDLGTDKDKEDWKSVHKMVVDSAYEVIKLKGYTSWAIGMSVADLCESILKNMHKCHPVSTLVKGMHGVNEEVFLSVPCILGNNGLTDVVHMTLKPEEEKQLVKSAETLWGVQKELTL
Protein: Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (EC 1.1.1.300) (NADPH-dependent carbonyl reductase) (CR) (RACR) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (Short chain dehydrogenase/reductase family 25C member 2) (Protein SDR25C2) (rabNRDR) (Q9GKX2)
Organism: Oryctolagus cuniculus (Rabbit)
Function: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal (Probable). Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin (By similarity). In the reverse reaction, catalyze the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency (By similarity). Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds.
Subcellular location: Peroxisome {ECO:0000250|UniProtKB:Q8WNV7}.
Interaction partners:
- Aldehyde oxidase 1
- Dehydrogenase/reductase 9
- aldehyde oxidase
- Aldehyde dehydrogenase 1 family member A2
- Lecithin retinol acyltransferase
- Cytochrome P450 26A1
- Short-chain dehydrogenase/reductase 3
- All-trans-retinol 13,14-reductase
- Cytochrome P450 family 27 subfamily C member 1
- Short-chain dehydrogenase/reductase 3
Sequence:
MASSGVTRRDPLANKVAIVTASTDGIGLAIARRLAQDGAHVVISSRKQQNVDRAVAALQAEGLSVTGTVCHVGKAEDRERLVATALNLHGGIDILVSNAAVNPFFGKLMDVTEEVWDKILDINVKAMALMTKAVVPEMEKRGGGSVVIVASIAAFNPFSGLGPYNVSKTALVGLTKNLALELAAQNIRVNCLAPGLIKTSFSKALWEDKAQEENIIQKLRIRRLGKPEECAGIVSFLCSEDASYITGETVVVAGGAPSRL
Protein: Integrin alpha ina-1 (Q03600)
Organism: Caenorhabditis elegans
Function: Plays a role in cell migration, axon fasciculation, and morphogenesis. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p. Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis.
Subcellular location: Membrane {ECO:0000269|PubMed:20226672}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, phagocytic cup {ECO:0000269|PubMed:20226672}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:20226672}. Note=Enriched at the cell contact with apoptotic cells and in phagocytic pseudopods during apoptotic cell engulfment. Co-localizes with src-1 during phagosome cup formation. {ECO:0000269|PubMed:20226672}.
Interaction partners:
- Integrin beta pat-3
- Ig-like domain-containing protein
- Integrin-linked protein kinase homolog pat-4
- Integrin alpha pat-2
- Collagen alpha-1
- Dystroglycan 1
- Netrin unc-6
- Ras-related protein ced-10
- Laminin-like protein epi-1
- Tyrosine protein-kinase src-1
Sequence:
MRECIISWTLLLCLSCVKSFNLDVNAPIYRYGPSGTNFGYSVAEHFKGDKPVMLIGAPRGESGQTGTERAGAMYACDINTFYNGGSNHWCEQVRFEYENVEDYAKRPNETRGRTVHPLGKNDQLLASTIVSKGTKNGSALVCAPLIRYHQTAAYPQGACYELESNLRLQSTYATCAQKNLPTTDRHNEYGGCMEGFSAAITQDTIVTGLIGAVKWTGGVFAKKSSANIFDSVVEKYTMNQPNGDMIRTRLVAHDYLGYSVDIGRFGFWYEDGKPITVVSGATRYGEHGAVIFLPFIQDSSSKLTLNEDKFIINGTAMGSAFGYSIEVVDLNGDGFDDLIVGAPFEHRSGIDGNFGGIVYVYFSQGVQRKQHESHLVFHPPKILKNPDFYSQFGLSITKLGNVDGDKSKLNDFAVGAPFAFDGAGAVYIYLGTKNIEKFRKKPAQVIKGNDLPNLPPGGMRSFGFSLSGGSDMDENGYPDLLIGSPSKNFVALLRSRPVISIETKHKMEKRMVDIDKGVNCPRGAKTCFPLDMVIYVDEETKRGAELVDFSSDVFMCNLEAIPFRADTTARGFIEGSHSHNYSWPCGSNSHVQKRTYRQLIYLPVQESKDWITPLKFRFTVSIRNEKKPVQPPQGSQLVDLKHYPVLNKYGASYEFDVPFNTLCGEDHTCQTDLSLKAAFKDIPLTSNGYVSNVGEKDYLDLTFTVENKKEKAYQANFYLEYNEEELELPQVQGSKRMIAETIGKNIVHLPLGNPMNGASKHQFTIQFKLTRGRTEGIGKALKFMAHVNSTSQETEEELKDNKWEAEVQIIKKAELEIYGISDPDRVFFGGKARAESELELEEDIGTMVRHNYTIINHGPWTVRNVEAHISWPYQLRSRFGRGKNALYLLDVPTITTEFTDGTSEVRKCFIKQQYEYVNPAEIKLNTKYSTQETAPHRVEHRMKREIDEDEEEQSDDLGAVEENIPWFSTANFWNLFAIKGGDGRPREVKHLSCQDNTANCFTVICHFDFIDANSAVVIDLRARLWNATFIEDYSDVESVKIRSFGKLQLDESQGIDDDPNNNAAFVETSADPDRPTIGDSRPIPWWIYVIAAVIGVLILSLIIICLSKCGFFKRNRLDQPSLYTAQLKHEREEWADTGL
Protein: Uncharacterized protein, isoform B (Q8IR40)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLKRNPFQYTLWSNLIMITQGDMACCNVSAVLRIYEYSMRRMHVGHNDEITRRFIIKETDVIMLKLFHNCLLFLRQSGHTNWMFALIRLSMELNFPYLTFECLQAHAGREKALIGFEEVVLRSGMPMPEIWTRVEQLRQAYCFLPLKDKLASSTNVFKNKMNAERYFCSDKLVPYVHALKSQNNRLHLVLVVVQLMKLPLIRSASLADKLNPCIEDFGESEAIEMLFAAIVDRHSYAVASLQYQFDAAMIDLAREMSVTPSYMPHLVGHKLYADTVSNMLLKCVEVFIGEESKRRLLLILYLRFQKLLIVLHKSMGKLTKKFFKDKRTRMRKLINLTENRNVISFYTEQALCEIEAKHYRLGFSIISRIITKKSEESSCISCVDTMHLYLVCAELHIHRGRISKAIGILVSLCLEKHAGVKQTTVYSKEQVLKGLRNAEKMVRAELKSLDTQPAEMSLEEYFQPNKLLILLRAICLIEVLNNRRHKEARMWLNDLQNNEFGPEAVKDSERKRFLREQIMEIQMLHLRLSFLVFGEVEFYTGFKKIKLHELLENGLEEFPRNMVFLQLWASLKSIMWHKQRSRLIRTKAGIASLAHLVVAIHNRFGIVDTNDKFSKEATRKMVCNRLVSIVETFLPTNLDRLDVEEEHYRILRRNSIYWRLYMIALSKTNASFRRSKEVLIMAMDECPWDKSLLMEGAKVLPVKLASLQDLMTEKEIRIFAMPEEVDVLRGF
Protein: Lysophospholipid transporter LplT (P39196)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Bifunctional protein Aas--phospholipid O-acyltransferase); Acyl-[acyl-carrier-protein] synthetase
- Uncharacterized lipoprotein YgdR
- Protein tas
- UPF0053 inner membrane protein YgdQ
- DNA mismatch repair protein MutH
- Ribonuclease E
- Flagellar transcriptional regulator FlhC
Sequence:
MSESVHTNTSLWSKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQVADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSKLVKANGLMEASTIAAILLGSVAGGVLADWHVLVALAACALAYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVLIFSLQHELLPAYALLMLIGVMGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGIYSLAVMIGIPVVPIGIGFGALFALAITALWIWQRRH
Protein: F-box protein 8 isoform 2 (A0A0S2Z576)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGQGLWRVVRNQQLQQEGYSEQGYLTREQSRRMAASNISNTNHRKQVQGGIDIYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPDENTYSHREQDSPKDTVHVTDMGNQAPQQLLAVAHGVGENICTVCGSELLYVQGYPG
Protein: Class E basic helix-loop-helix protein 22 (bHLHe22) (Class B basic helix-loop-helix protein 5) (bHLHb5) (Protein BETA3) (Q8C6A8)
Organism: Mus musculus (Mouse)
Function: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- PR domain zinc finger protein 8
Sequence:
MERGLHLGAAAASEDDLFLHKSLGTSAAKRLEAAFRSTPPGMDLSLAPPTRERPASSSSPLGCFEPADPEGAGLRLPPPGGGGGASGGGGGVSVPGLLVGSAGVGGEPSLSSLPAGAALCLKYGESAGRGSVAESSGGEQSPDDDSDGLCELVLRAGGPDPRASPRAGGGSAKVAEGCSNAHLHGGSGLPPGGPTSGGGSGGGGGGSSKKSKEQKALRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQAISAASLPSSAAAAAAAAALHPALGAYEQAAGYPFSAGLPPAASCPEKCALFNSVSSSLCKQCTEKP
Protein: Probable Rho-type GTPase-activating protein 2 (Q10164)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTPase-activating protein for Rho-type proteins.
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Cell division control protein 42 homolog
- GTP-binding protein rho2
- Probable Rho-GTPase-activating protein 6
- Probable Rho-type GTPase-activating protein 4
- Rho-type GTPase-activating protein 1
- Probable Rho-type GTPase-activating protein 3
- Protein scd2/ral3
- Probable Rho-GTPase-activating protein 7
- GTP-binding protein rho1
- Serine/threonine-protein kinase shk1/pak1
Sequence:
MVKMDVVRTTGFFLRSEPTTCRITTFAYSAEIIYFHAETTFLFEKIMKEGNELEKYSKIELNSEIWEDEEEEDNSGIVSQNERLMKLVNKQREIIYELHKDLEKVKKDNTSLRMRLSKYESTDSFPSSQPSRANSPQSDSYSSPYEKGKLFPKISLKSSKDVPTASAHISSSDHEKSSSVSLSALNNYNKTTDIKARSLDRLSDMTRPKLLLNTKRSHRSSEEPGASSPVTSPILKDSQKERIQALRNKAIKTYSVSTESAERIDSIRSDNLSPLSLNTSSFRRPITKPTPFNSDSNISIDPKDNNSNKQDHFAEIEDELRQQFLDIKVGRANASSPRRKSISIVKPHGISSPKHSTNNLSSKSGKFHSDFRVVSENVLLQARSETNSPIIENKEANNFLAPTSNVPAYSTPARPTESPPPPPISSSSTTPRPDDKPSLPPRGLSEDNDSLSLQKTGSSDTRRSSFSTLKIPDSDICFTRRRSDSNRTWTVIDPHHSQSFDNDILAEIPTSKLDNSSQKSPGKLSSKGLLNSFSPISPFSKSKSHNHHPSSQVEKSTSNSKGSMLPLDTLYNNKLSFRLDESLVRYLRFELMKTSLASLSPDFDCIGLQFVVGVSASSHLASQWKDEVWSFTRSIGECRSFATSFVLDIGAPPFPTLDWFTNDSSVIQNELLRRSVDTYFRYIFQTDLKLEQRIKLLEFLSSDTLREYLHDVFFLPPEHAQKEGVLLKYIENSGLVSRYFYLKDNILYFAENRNSPVLGTIHLKDAQVNRYNANLPIFSIIDPPHEFLTGENYQSAFVIQEKQTETRTGTATVHVLLARDVEDQKSWLRAILRQVPGSTSPLNASPFSVLSSDFPGSSRYRDQSSPIRFYGKADSRPVSQEAILSQDISSSPSPVLPPSENVASYADDSLVSNLTMSPKLRDSMEQVPLENHREFEISDRVSELSFDSSTGSVLEIADTRRNQDAPEKHVPVIEIQSSRPSLEKTDQSTPVELLIDSHSQNSQNEEKRSRMKFWAFPHHKAENYEQISDTNIPVIETNVMLSPSSTTSAEPLQKHIVRKSGIFGLPLNEAVNISTQFNDSGLPIVVYRCIEYLESCRAEKEEGIYRLSGSASTIKHLKEQFNEGVDYDLLSSDEEFDVHVIAGLLKLYLRNLPTNLLDTSMHKLFELLPNVPNDSAALGELCDVISKLPPENFALLDSLLHHLRRIIAFEKVNKMNIRNVCIVFSPTLNIPSDIFMMLILNYDHIFTDISRQTNGAQNESDSDVSDDNGEDNEFF
Protein: Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin-2) (Q99L88)
Organism: Mus musculus (Mouse)
Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
Subcellular location: Cell membrane, sarcolemma {ECO:0000269|PubMed:9214383}; Peripheral membrane protein {ECO:0000269|PubMed:9214383}; Cytoplasmic side {ECO:0000269|PubMed:9214383}. Cell junction {ECO:0000269|PubMed:9214383}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9214383}. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
Interaction partners:
- Dystrophin
- Dystrobrevin alpha
- Utrophin
- Delta-sarcoglycan
- Gamma-sarcoglycan
- Dystroglycan 1
- Alpha-sarcoglycan
- Beta-sarcoglycan
- Sarcospan
- Dystrobrevin beta
Sequence:
MAVAAAAVAAPAGGGGARAQRSGLLEVLVRDRWHKVLVNLSEDALVLSCEEGAAAYNGIGAATNGSFCRGSGTGHPVPGVAQAPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGGSAEPLSSQSFSFHRDRKSIPLKMCYVTRNMTLADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNAGDLLTRVVADIREQLGKTGIAGSREIRHLGWLAEKVPGESEKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHSYPLLATRLVHSGPGKGSPQAGMDLSFATRTGTKQGIETHLFRAEISRDLSHWTRSIVQGCHNSAELTAEITTACTYRNQECRLTIHYDNGFSISTEPQDGAFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKEGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA
Protein: Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) (GABAAR subunit alpha-4) (P28471)
Organism: Rattus norvegicus (Rat)
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9D6F4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48169}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48169}.
Interaction partners:
- Gamma-aminobutyric acid receptor subunit delta
- Gamma-aminobutyric acid receptor subunit beta-1
- Gamma-aminobutyric acid receptor subunit beta-3
- Vesicle-fusing ATPase
- Huntingtin-associated protein 1
- Inactive phospholipase C-like protein 1
- Trafficking kinesin-binding protein 2
- Gamma-aminobutyric acid type B receptor subunit 2
- Gamma-aminobutyric acid receptor subunit gamma-2
- Gamma-aminobutyric acid receptor subunit gamma-1
Sequence:
MVSVQKVPAIVLCSGVSLALLHVLCLATCLNESPGQNSKDEKLCPENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVNSRTEVGNHSSKTTAAQESSETTPKAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSASARPAFGARLGRIKTTVNTTGVPGNVSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM