wanglab/gogpt-training-data huggingface dataset:
Protein: Candida glabrata strain CBS138 chromosome I complete sequence (Q6FQI9)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome I complete sequence
- glycerol kinase
- Candida glabrata strain CBS138 chromosome K complete sequence
- glycerol-1-phosphatase
- glycerol-1-phosphatase
- Candida glabrata strain CBS138 chromosome F complete sequence
- Candida glabrata strain CBS138 chromosome E complete sequence
- alcohol dehydrogenase
- alcohol dehydrogenase
Sequence:
MPEPITLRVNAALFDVDGTIIISQPALAAFWRDFGKDKPYFDAEHVIHVSHGWRTYDAIAKFAPDFADEETVTKLEGEIPDKYGKEAIEVAGAVKLCNSFNELPKEKWAVATSGTREMASKWFAVLGIKKPTYFITANDVKKGKPNPEPYLKGREGLGYPINTHYPEKSKVVVFEDAPAGIAAGKAAGCKIIGIATTFSASSLREKGCDIVIKDHRSVRVAGYDKETDEVILVFDDYLYVRDDIQKW
Protein: Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein) (Q9BT92)
Organism: Homo sapiens (Human)
Function: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15731013}. Cytoplasm {ECO:0000269|PubMed:18931701}. Cell membrane {ECO:0000305|PubMed:15731013, ECO:0000305|PubMed:18931701}. Mitochondrion {ECO:0000269|PubMed:18931701}. Cell junction, desmosome {ECO:0000269|PubMed:15731013}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:38538594}.
Interaction partners:
- E3 ubiquitin-protein ligase Mdm2
- Axin-1
- Hypoxia-inducible factor 1-alpha
- Glycogen synthase kinase-3 beta
- Cellular tumor antigen p53
- Mitofusin-2
- Protein Mdm4
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Apoptosis regulator Bcl-2
- Cyclin-dependent kinase 4
Sequence:
MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGHPKIAWN
Protein: Thioredoxin domain containing 9 (B8ZZX4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEADASVDMFSKVLEHQLLQTTKLVEEHLDSEIQKLDQMDEDELERLKEKRLQALRKAQQQKQEWLSKGHGEYREIPSERDFFQEVKESENVVCHFYRDSTFRCKILDRHLAILSKKHLETKFLKLNVEKAPFLC
Protein: Thrombopoietin (C-mpl ligand) (ML) (Megakaryocyte colony-stimulating factor) (Megakaryocyte growth and development factor) (MGDF) (Myeloproliferative leukemia virus oncogene ligand) (P40226)
Organism: Mus musculus (Mouse)
Function: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P40225}.
Interaction partners:
- Thrombopoietin receptor
- Erythropoietin
- Granulocyte colony-stimulating factor
- Kit ligand
- Erythropoietin receptor
- Leptin
- Prolactin
- Prolactin-6A1
- Prolactin-5A1
- Fms-related tyrosine kinase 3 ligand
Sequence:
MELTDLLLAAMLLAVARLTLSSPVAPACDPRLLNKLLRDSHLLHSRLSQCPDVDPLSIPVLLPAVDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEPSCLSSLLGQLSGQVRLLLGALQGLLGTQLPLQGRTTAHKDPNALFLSLQQLLRGKVRFLLLVEGPTLCVRRTLPTTAVPSSTSQLLTLNKFPNRTSGLLETNFSVTARTAGPGLLSRLQGFRVKITPGQLNQTSRSPVQISGYLNRTHGPVNGTHGLFAGTSLQTLEASDISPGAFNKGSLAFNLQGGLPPSPSLAPDGHTPFPPSPALPTTHGSPPQLHPLFPDPSTTMPNSTAPHPVTMYPHPRNLSQET
Protein: Inner kinetochore subunit MCM22 (CENP-K homolog) (Constitutive centromere-associated network protein MCM22) (Minichromosome maintenance protein 22) (P47167)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Interaction partners:
- Inner kinetochore subunit IML3
- Inner kinetochore subunit MCM16
- Inner kinetochore subunit OKP1
- Inner kinetochore subunit CTF3
- Inner kinetochore subunit NKP1
- Inner kinetochore subunit MCM21
- Inner kinetochore subunit CHL4
- Inner kinetochore subunit CTF19
- Inner kinetochore subunit AME1
- Inner kinetochore subunit CNN1
Sequence:
MDVEKDVLDVYIKNLENQIGNKRYFLKQAQGAIDEITKRSLDTEGKPVNSEVFTELLRKPMFFSERADPIGFSLTSNFLSLRAQSSSEWLSLMNDQSVDQKAMLLLQNNINSDLKELLRKLQHQMTIMDSKKQDHAHIRTRKARNKELWDSLADFLKGYLVPNLDDNDESIDSLTNEVMLLMKRLIEHDLNLTLNDFSSKTIPIYRLLLRANIITVIEGSTNPGTKYIKLIDFNETSLT
Protein: Armadillo repeat containing 6 (F5H2X2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVSKRIAQETFDAAVRENIEEFAMGPEEAVKEAVEQFESQGVDLSNIVKTAPKVSADGSQEPTHDILQMLSDLQESVASSRPQEVSAYLTRFCDQCKQDKACRFLAAQKGAYPIIFTAWKLATAGDQGLLLQSLNALSVLTDGQPDLLDAQGLQLLVATLT
Protein: RNA binding protein (Q9XY40)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MIRASIVKRMAPCTLFLNKGKVISWMSGRGFGFIEDDADKKQHFVHFSALQTETGGFRALTVGQEVEFEVASQDGRTRAENVTSPGGAKLPSGPRPPEGAGRGRGFGGGRGGRDFGGDRNSGRGRNDNQQGGQHQSFSDDF
Protein: Pygopus homolog 1 (Q9D0P5)
Organism: Mus musculus (Mouse)
Function: Involved in signal transduction through the Wnt pathway.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- B-cell CLL/lymphoma 9-like protein
- B-cell CLL/lymphoma 9 protein
- Catenin beta-1
- Lymphoid enhancer-binding factor 1
Sequence:
MSAEQDKEPIALKRVRGGDSGLDGLGGPNIQLGSPDKKKRKANTQGSSFPPLSEYAPPPNPNSDHLVAANPFDDSYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSNFGNPPYNNVLTQDINMPGQHFRQGSAENFSQIPPQNVGQVSNPDLASNFAPGNNSNFTSPLETNHSFIPPPNAFGQAKAPLPKQDFTQGATKTPNQNSSTHPPHLNMEDPVNQSNVELKNVNRNNVVQENSRSGSAEATNNHANGTQNKPRQPRGAADLCTPDKSRKFSLLPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTREAFGPPAVGGDA
Protein: Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (A0A060YRM0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Ig-like domain-containing protein
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Endothelin-3
- Neuropeptide Y
- Guanine nucleotide-binding protein G
- Uncharacterized protein
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit alpha-13
Sequence:
MSNMTNETILWGPPYSLQISLPLTILVGMLILLTVFGNVLVVIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANELMGYWYFGKVWCEIYLALDVLFCTASIAHLCAISLDRYWSITKAIEYNLKRTPRRIKCIIVIVWVIAAVISFPPLISMEKESDKEEGPVCKINEDKWYMISSSIGSFFVPCIIMILVYIRIYQIAKKRTRVPPGDRKPKMAASVSPVTGKKENGAGGVGEDEKEGEINGVDMEDSSSSDHQVNNPCSIKKKKHTAKTKLSQIKPGVDHPALPKLVVRQSSKGSRWKGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTALCDSCYIPDTLFKFFFWFGYCNSSANPIIYTIFNNDFRRSFKKILCRDNRRMV
Protein: Lactose-binding lectin l-2 (Serum lectin 2 isoform X1) (Serum lectin 2 precursor) (Serum lectin isoform 2) (Q800Z5)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MAMLTISLLLCAAVALSGATGAKGAEEGVVPAETRNQCPTGWFQFGSRCFMFVETARSWPLAERHCVSLGANLASVHSSADDQFLQAIAGCKTGAFSTTWIGGFDAVQDRLWFWSDGSEFDYQNWAKGEPNNSGGREPCIVINWGDEYRWNDIKCGNSFPSVCSKRICEIQKN
Protein: Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (Sterol carrier protein X) (SCP-X) (P32020)
Organism: Mus musculus (Mouse)
Function: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
Subcellular location: [Isoform SCP2]: Cytoplasm {ECO:0000269|PubMed:11003606, ECO:0000269|PubMed:26901662}. Peroxisome {ECO:0000269|PubMed:11003606, ECO:0000269|PubMed:26901662}. Endoplasmic reticulum {ECO:0000269|PubMed:11003606}. Mitochondrion {ECO:0000269|PubMed:11003606, ECO:0000269|PubMed:26901662}.; SUBCELLULAR LOCATION: [Isoform SCPx]: Peroxisome {ECO:0000269|PubMed:26901662}.
Interaction partners:
- Peroxisomal targeting signal 1 receptor
- Peroxisomal acyl-coenzyme A oxidase 1
- Peroxisomal multifunctional enzyme type 2
- PEX5-related protein
- Peroxisomal acyl-coenzyme A oxidase 3
- 3-ketoacyl-CoA thiolase A, peroxisomal
- 3-ketoacyl-CoA thiolase B, peroxisomal
- Long-chain fatty acid transport protein 5
- Acyl-coenzyme A thioesterase 8
- Bile acid-CoA:amino acid N-acyltransferase
Sequence:
MPSVALKSPRLRRVFVVGVGMTKFMKPGGENSRDYPDMAKEAGQKALEDAQIPYSAVEQACVGYVYGDSTSGQRAIYHSLGLTGIPIINVNNNCSTGSTALFMAHQLIQGGLANCVLALGFEKMERGSIGTKFSDRTTPTDKHIEVLIDKYGLSAHPITPQMFGYAGKEHMEKYGTKVEHFAKIGWKNHKHSVNNTYSQFQDEYSLEEVMKSKPVFDFLTILQCCPTSDGAAAAILSSEEFVQQYGLQSKAVEIVAQEMMTDLPSTFEEKSIIKVVGYDMSKEAARRCYEKSGLTPNDVDVIELHDCFSVNELITYEALGLCPEGQGGTLVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGLGGAVVVTLYRMGFPEAASSFRTHQVSAAPTSSAGDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDLLALMTGKMNPQSAFFQGKLKIAGNMGLAMKLQNLQLQPGKAKL
Protein: Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase) (HPAT) (HspAT) (P06986)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Histidinol dehydrogenase
- Histidine biosynthesis bifunctional protein HisB
- Imidazole glycerol phosphate synthase subunit HisF
- 1-
- Imidazole glycerol phosphate synthase subunit HisH
- ATP phosphoribosyltransferase
- Histidine biosynthesis bifunctional protein HisIE
- T-protein
- Bifunctional chorismate mutase/prephenate dehydratase
- Aromatic-amino-acid aminotransferase
Sequence:
MSTVTITDLARENVRNLTPYQSARRLGGNGDVWLNANEYPTAVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPTLDNWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRGKAIVVADEAYIEFCPQASLAGWLAEYPHLAILRTLSKAFALAGLRCGFTLANEEVINLLMKVIAPYPLSTPVADIAAQALSPQGIVAMRERVAQIIAEREYLIAALKEIPCVEQVFDSETNYILARFKASSAVFKSLWDQGIILRDQNKQPSLSGCLRITVGTREESQRVIDALRAEQV
Protein: Protein REVEILLE 1 (F4KGY6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Morning-phased transcription factor integrating the circadian clock and auxin pathways. Binds to the evening element (EE) of promoters. Does not act within the central clock, but regulates free auxin levels in a time-of-day specific manner. Positively regulates the expression of YUC8 during the day, but has no effect during the night. Negative regulator of freezing tolerance.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Two-component response regulator-like APRR1
- Transcription factor LUX
- Two-component response regulator-like APRR5
- Two-component response regulator-like APRR7
- Two-component response regulator-like APRR9
- Protein EARLY FLOWERING 4
- AT-hook motif nuclear-localized protein 20
- Phytochrome B
Sequence:
MASSPLTANVQGTNASLRNRDEETADKQIQFNDQSFGGNDYAPKVRKPYTITKERERWTDEEHKKFVEALKLYGRAWRRIEEHVGSKTAVQIRSHAQKFFSKVAREATGGDGSSVEPIVIPPPRPKRKPAHPYPRKFGNEADQTSRSVSPSERDTQSPTSVLSTVGSEALCSLDSSSPNRSLSPVSSASPPAALTTTANAPEELETLKLELFPSERLLNRESSIKEPTKQSLKLFGKTVLVSDSGMSSSLTTSTYCKSPIQPLPRKLSSSKTLPIIRNSQEELLSCWIQVPLKQEDVENRCLDSGKAVQNEGSSTGSNTGSVDDTGHTEKTTEPETMLCQWEFKPSERSAFSELRRTNSESNSRGFGPYKKRKMVTEEEEHEIHLHL
Protein: Large ribosomal subunit protein uL13m (39S ribosomal protein L13, mitochondrial) (L13mt) (MRP-L13) (Q9VJ38)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9BYD1}.
Interaction partners:
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL19m
- Ribosomal protein
- Large ribosomal subunit protein uL15m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS12m
- Large ribosomal subunit protein uL24m
Sequence:
MSIAKRVQQWATFARTWHIYDCTWQNPFESAKLVKTHLLGLQKPIYHPMNDCGDHVVLINTREIALPGDEWVKRVYFHHTGYPGGASWTLAWQLHEKDPTMVMKKAVYNSMRGNLQRRHTMQRLHLFADDQVPEEILQNVTNQIRTPRSIPQRLDHIDKETLENFPNIMDYPKDYILR
Protein: Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) (Q6JT77)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MEWYVLVLMLSFPTLSQADCSAQCLRCAQQISDLDSAVNRLTCTLECEGAVPPTGTLDRCEKALQGLSDDLAELNTGADGETNALNTDEDLQEKTSNLVKRYGGFIKRIDKNKNKFFSSPWKENAILKGLFAKKYGESLSKLGERDLPSITEDDEGEDMGAENETGVYDNEVPLNEVKRYGGFLRKFGPKRSYFVDDTNPQVLQKRYGGFMRRIRPKLRWDNQKRYGGFLRRHFKISVRSDEEPSSYEDYAL
Protein: Seven TM Receptor (O16332)
Organism: Caenorhabditis elegans
Interaction partners:
- G-protein coupled receptors family 1 profile domain-containing protein
- EF-hand domain-containing protein
- Neurotransmitter-gated ion-channel ligand-binding domain-containing protein
- Serpentine Receptor, class Z
- G-protein coupled receptors family 1 profile domain-containing protein
- Neurotransmitter-gated ion-channel ligand-binding domain-containing protein
- EF-hand domain-containing protein
- TPM domain-containing protein
- Dipeptidyl peptidase family member 6
- Neur_chan_memb domain-containing protein
Sequence:
MMLYRVIHYIQFAAFAVSQCTNGLLLYLIWTKARKVLGAYSYLMLAFSLYAILYNYVDIITLPLVVIEKQMYVVVNHGPIRNVPIFGFLFTCLFGSSFGLCISLLSTQFFYRYLAVCRPKSLHYLEGRRLALIFIPAIFVSVIWFFFCFFGLDITVEKQEMLKEPFMEFYNEDSNTMSFVSGLFWSLDENGTKHWNMKDCIGSLGLAALMIVCCLTIVFCGVKTYKKMNDSGNSLSNRTKELNRQLFVTLSLQTLLPFMLMYGPVGLLFIFPLFQIKFDILSSSAAASTAIYPAVEPLIAIFCIKTFRKALCFNQCIRQTARITSTAASTAAKSN
Protein: SKP1-like protein 6 (AtSK6) (Q1PEF6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Cullin-1
- Cullin-2
- Cullin-like protein 3
- Putative cullin-like protein 1
- Putative cullin-like protein 2
- RING-box protein 1a
- RING-box protein 1b
- F-box protein 7
- Elongin-C
- Cullin-3A
Sequence:
MMIKGMAEDDCADNGIPLPNVTSKILLLVIEYCKKHVVESKEEDLKKWDAEFMKKMEQSILFDVMMAANYLNIQSLLDLTFSNCR
Protein: Serine acetyltransferase 5 (AtSAT-5) (EC 2.3.1.30) (AtSERAT1;1) (SAT-c) (Q42538)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9830017}.
Interaction partners:
- Cysteine synthase 1
- S-sulfo-L-cysteine synthase
- Cysteine synthase, mitochondrial
- Putative inactive cysteine synthase 2
- Bifunctional cystathionine gamma-lyase/cysteine synthase
- Cysteine synthase, chloroplastic/chromoplastic
- Phosphoserine phosphatase, chloroplastic
- Serine racemase
- Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic
- Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic
Sequence:
MPPAGELRHQSPSKEKLSSVTQSDEAEAASAAISAAAADAEAAGLWTQIKAEARRDAEAEPALASYLYSTILSHSSLERSISFHLGNKLCSSTLLSTLLYDLFLNTFSSDPSLRNATVADLRAARVRDPACISFSHCLLNYKGFLAIQAHRVSHKLWTQSRKPLALALHSRISDVFAVDIHPAAKIGKGILLDHATGVVVGETAVIGNNVSILHHVTLGGTGKACGDRHPKIGDGCLIGAGATILGNVKIGAGAKVGAGSVVLIDVPCRGTAVGNPARLVGGKEKPTIHDEECPGESMDHTSFISEWSDYII
Protein: Tumor necrosis factor receptor superfamily member 11B (Osteoprotegerin) (O08727)
Organism: Rattus norvegicus (Rat)
Function: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 11
- Transcription factor Sp7
- Runt-related transcription factor 2
- Tumor necrosis factor ligand superfamily member.
Sequence:
MNKWLCCALLVFLDIIEWTTQETFPPKYLHYDPETGRQLLCDKCAPGTYLKQHCTVRRKTLCVPCPDYSYTDSWHTSDECVYCSPVCKELQTVKQECNRTHNRVCECEEGRYLELEFCLKHRSCPPGLGVLQAGTPERNTVCKRCPDGFFSGETSSKAPCRKHTNCSSLGLLLIQKGNATHDNVCSGNREATQNCGIDVTLCEEAFFRFAVPTKIIPNWLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDLCESSVQRHIGHANLTTEQLRILMESLPGKKISPDEIERTRKTCKPSEQLLKLLSLWRIKNGDQDTLKGLMYALKHLKAYHFPKTVTHSLRKTIRFLHSFTMYRLYQKLFLEMIGNQVQSVKISCL
Protein: Interferon gamma (IFN-gamma) (E5G7F4)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|PIRNR:PIRNR001936}.
Interaction partners:
Sequence:
MKYTSSFLALLLCGLLGFSGSYGQGPFFKEIENLKEYFNASNPDVAKGGPLFSEILKNWKEESDKKIIQSQIVSFYFKLFENLKDNQVIQRSMDIIKQDMFQKFLNGSSEKLEDFKRLIQIPVDDLQIQRKAINELIKVMNDLSPKSNLRKRKRSQNLFRGRRASM
Protein: Uncharacterized fimbrial-like protein SfmF (P38052)
Organism: Escherichia coli (strain K12)
Function: Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
Subcellular location: Fimbrium {ECO:0000250}.
Interaction partners:
- Uncharacterized fimbrial-like protein SfmH
- Type 1 fimbrin D-mannose specific adhesin
- Probable fimbrial chaperone SfmC
- Chaperone protein FimC
- Type-1 fimbrial protein, A chain
- Uncharacterized fimbrial-like protein SfmA
- Probable autotransporter YfaL
- Outer membrane usher protein SfmD
- Type 1 fimbriae regulatory protein FimE
- Type 1 fimbriae regulatory protein FimB
Sequence:
MRRVLFSCFCGLLWSSSGWAVDPLGTININLHGNVVDFSCTVNTADIDKTVDLGRWPTTQLLNAGDTTALVPFSLRLEGCPPGSVAILFTGTPASDTNLLALDDPAMAQTVAIELRNSDRSRLALGEASPTEEVDANGNVTLNFFANYRALASGVRPGVAKADAIFMINYN
Protein: Non-reducing end alpha-L-arabinofuranosidase BoGH43A (EC 3.2.1.55) (Glycosyl hydrolase family protein 43A) (BoGH43A) (A7LXT8)
Organism: Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153)
Function: Alpha-L-arabinofuranosidase involved in xyloglucan degradation by mediating the cleavage of terminal non-reducing alpha-L-arabinofuranoside residues in xyloglucan branches, converting the 'S' units to 'X' units.
Subcellular location: Periplasm {ECO:0000305}. Note=Periplasmic localization is predicted by analogy with the archetypal sus locus. {ECO:0000269|PubMed:24463512}.
Interaction partners:
Sequence:
MRNALFLIFISLCSVCKSSAQGYSNPVIPGFHPDPSVCKAGDDYYLVNSSFQYFPGVPLFHSKDLVHWEQIGNCLTRPSQLDLTNANSGSGIFAPTIRYNDGVFYMITTNVSGKGNFLVHTTDPRSEWSEPVWLEQGGIDPSLYFEDGKCFMVSNPDGYINLCEIDPMTGKQLSSSKRIWNGTGGRYAEGPHIYKKDGWYYLLISEGGTELGHKVTIARSRYIDGPYQGNPANPILTHANESGQSSPIQGTGHADLVEGTDGSWWMVCLAYRIMPGTHHTLGRETYLAPVRWDKDAWPVVNSNGTISLKMDVPTLPQQEMKGRPERIDFKEGKLSPEWIHLQNPEAKNYIFTKDGKLRLIATPVTLSDWKSPTFVALRQEHFDMEASAPVVLQKAGVNDEAGISVFMEFHSHYDLFVRQDKDRKRSVGLRYKLGEITHYAKEVSLPTDGEVELVVKSDINYYYFGYKVNGIYHDLGKMNTRYLSTETAGGFTGVVLGLYITSASKDSKAYADFEYFKYKGKPGENK
Protein: Methyltransferase (Q57ZS4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Alpha N-terminal protein methyltransferase 1
- EMG1/NEP1 methyltransferase
- Electron transfer flavoprotein subunit beta
Sequence:
MLQWVVKEVEGPFGNIATIHWAVPEGQDDGESSDNTAESQKLHHKVGQGGKVQPELQHLLEDAEDQLGAVLWNSNSVAMGHLQKHVLQNHDKACHVVELGAGVGCLGIGLAMAGARVVITDMKELVPLMEKNIELNKERILSRSNGKGSCVAMTWRWGPPPLVKQKHNAKRVKINNARQHSSNADVPSAQNERGRSPYLLPSPAFVEMQRLLDHVDLVVLCDALYGNPKSWPQLLYTLSEILAANPRCEVINFCEQRVDDVEGDFLNLLQQENAKLPPPANSAVGPEGNETMEEALLRMRGSYKWSTSTEVVGEGPSDLGMPVRVTRISWVHRSGKWGTGASTASRDVVVDGADLGRKSGGRKRERTR
Protein: Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7) (P39108)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal, such as 3-oxoacyl-CoA thiolase. Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol. Cargo protein-binding triggers interaction with PEX21 and formation of a ternary complex composed of PEX21 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:7957058}. Peroxisome matrix {ECO:0000269|PubMed:7535304, ECO:0000269|PubMed:7957058}.
Interaction partners:
- Peroxisomal protein PEX21
- Proteasome subunit beta type-6
- Peroxisomal membrane protein PEX14
- Peroxisomal targeting signal receptor
- 3-ketoacyl-CoA thiolase, peroxisomal
- Peroxisomal membrane protein PEX13
- Peroxisomal membrane protein PEX18
- Peroxisome biogenesis factor 10
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX17
Sequence:
MLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG