wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Zinc finger protein 238) (Zfp-238) (Q9WUK6)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus.
Subcellular location: Nucleus. Note=Associates with condensed chromatin.
Interaction partners:
- Forkhead box protein J3
Sequence:
MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHMAGDLPSDEDEGEDDKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMENSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK
Protein: Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) (Q8BHN3)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q14697}. Golgi apparatus {ECO:0000250|UniProtKB:P79403}. Melanosome {ECO:0000250|UniProtKB:Q14697}.
Interaction partners:
- Glucosidase 2 subunit beta
- Mannosyl-oligosaccharide glucosidase
- Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
- Calnexin
- N-acetylglucosamine-1-phosphotransferase subunit gamma
- Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Hypoxia up-regulated protein 1
- Protein disulfide-isomerase A3
- Endoplasmic reticulum chaperone BiP
- Staphylococcal nuclease domain-containing protein 1
Sequence:
MAAIAAVAARRRRSWLSLVLAYLGVCLGITLAVDRSNFKTCDESSFCKRQRSIRPGLSPYRALLDTLQLGPDALTVHLIHEVTKVLLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPPTARLSVSGRDDNSVELTVAEGPYKIILTAQPFRLDLLEDRSLLLSVNARGLMAFEHQRAPRVPQESKDPAEGNGAQPEATPGDGDKPEETQEKAEKDEPGAWEETFKTHSDSKPYGPTSVGLDFSLPGMEHVYGIPEHADSLRLKVTEGGEPYRLYNLDVFQYELNNPMALYGSVPVLLAHSFHRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDIRWMSESGIIDVFLMLGPSVFDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNMPCDVIWLDIEHADGKRYFTWDPTRFPQPLNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELRNHGLYVKTRDGSDYEGWCWPGSASYPDFTNPRMRAWWSNMFSFDNYEGSAPNLYVWNDMNEPSVFNGPEVTMLKDAVHYGGWEHRDIHNIYGLYVHMATADGLIQRSGGIERPFVLSRAFFSGSQRFGAVWTGDNTAEWDHLKISIPMCLSLALVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLASQYQDAIRDALFQRYSLLPFWYTLFYQAHKEGFPVMRPLWVQYPEDMSTFSIEDQFMLGDALLIHPVSDAGAHGVQVYLPGQEEVWYDIQSYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKDDPITLFVALSPQGTAQGELFLDDGHTFNYQTRHEFLLRRFSFSGSTLVSSSADPKGHLETPIWIERVVIMGAGKPAAVVLQTKGSPESRLSFQHDPETSVLILRKPGVSVASDWSIHLR
Protein: TSL-kinase interacting protein 1 (Myb-related protein TKI1) (Q8LJT8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus.
Interaction partners:
- Serine/threonine-protein kinase TOUSLED
- At4g33690
- SWAP
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- At3g27340
- At3g57220
Sequence:
MLKQFTHYCEMQAELIPEGPNGEGRLSNQNSNPNLLSSASISITQFPAKKPTRQWAAWTHQEEESFFTALRQVGKNFEKITSRVQSKNKDQVRHYYYRLVRRMNKLLGPDLSLDAKNPKDTNAAMLRWWSLLEKYSCKASKLHLKPRRFKLFIEALEHQLLKDRRKSIRKRTCQGENLSSASLGNISSHSRERGLDNRPFKLILSDGQNVKKLGPGRASTKHGESLSVNLGDEKEDTAFGRGGRQRRKQGYRKWEKAAIDGVSLVADAAEHLERTSIDKDMDDQTDLGPTRYLTGKSPLSLCSAGDVPLSDANMQFSAKLKLQLFPIDECTRRSLEMDKHNPHLELTLSNRKKISSVLEHLNRKWGSSSCATGELLLFPYNARKETVTCHQRWTHDSFLSAAEVHSMVGSPSVFRLRYGWFVHDASGSIISQVPTSDPCPSLEDDMNVDRLNEVNMLLTESGPLSVHSTAEQTTSVEPSQGLVCASGVHDRPARSRDDYEPASTSITPLEHLSGGNAQSPGEWADSLTNISIGDLLSEVPDDIDSDGVDPPATEGSHYLLRDVPFTSDSFDAAIAAHILRHQNKPSAQLPLTSGSSSLWDDEETRDAFSFQKNRFANSTELASVASPKGVGRVNGEPSQLVEASSGDEGSYNPHDDGDPMEEGPADPHTMDSPGKTPCGLADVYWPDSLGPLDLDIRSSKYTDDLILSESLGGLSRLIATSLDAFQNCSLFGFDNKKDKSNMV
Protein: LP24049p (Toucan, isoform D) (Q8IPZ2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLAIVILMTGGVGVCINPNRSDQKTAFKVVATSVKGGRSYSKDSHKSSHTDLSLMCNASSSRPSNSASGSGSPKLLANTQLRAAKKRDVRNLSISPTDLGPPPKTQQTTKGQSTRSKSSATPTPTPTSIHKRLNGTLASTAAIATPIKGVATKSGATNKLQQSAKTKSTASIKSPAIVGVSEESLRSGVDQTELQELNNGQSATGCPTPPMARDSKRTSIGNELPCETEAKLKRCEDQQDPQASTTASPLPMINPQEQEASGQVKEATITTANEPNALSLPDEISNSVSSTTMLATPRVDIAAQYPVLKPFTENGELDCARLAKFFQDTQFERKEEQRQILGLSVMVQFMSKELDAVACKENKHQCARTKGTLEKTILLLQHTQKDCERLREDLEDKGLEWIQRQQEKEYLHRTELKQAEEKLMEVQLRAKLKFCELESQLRAKDEESKQAQEAYRMEVSHKLALKQEHLRTAEQKIQELQTRLQQVETEEQGHREELIRKENIHTARLAEANQREQDLIDRVKSLTKELNTLKANKEHNERDLRDRLALSQDEISVLRTSSQRRSPCTSLPDNASAELNRLTSEADSLRCVLELKQAEISALSKAKADLIHESEERLKLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQKAYKYESIKRTRLTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNSLSSHSRCSLGRSGLEIAVTTSSPTSPVMKGMIERNDSVSWTLEIEDESFKGNTSKIVRRAGSLRSNNERCPIQRRQTLTSNGHSNGSATNGGSSPAHPNPLSQSMSATALLRSSSNSGESEGRPLSRARSKSMCIKASATSSAVCESSGQRKKPQDELSLADWPEDIPLCSSSPQAPGIEMRPRSSTMKLMSSEAKKFQEIQESAGEAMVSGANSEDESCSASSEDIMRSSSASSTASGGSLSKRPKQPPSRMSIEEALPCTPMEVSWSEDAADANGLA
Protein: Solute carrier family 2, facilitated glucose transporter member 6 (Glucose transporter type 6) (GLUT-6) (Q9UGQ3)
Organism: Homo sapiens (Human)
Function: Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:30431159}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Major facilitator superfamily
Sequence:
MQEPLLGAEGPDYDTFPEKPPPSPGDRARVGTLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILLLSFMPNSPRFLLSRGRDEEALRALAWLRGTDVDVHWEFEQIQDNVRRQSSRVSWAEARAPHVCRPITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIESFFRTGRRSFLR
Protein: Coiled-coil domain-containing protein 39 (Q57WL0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNLEVVDATAEALPLELLNAVNKELTAQLSRHEEIHDGHVREVQDQRRRLEFVKEHLGNVRGEIVNTQALADSKKREMESELHMYRLLLRECGRLKQRQTQMQAEQADVQERLQVVQDRLFTENLRMAELKNSMAYNQEALEQWDAARQQKESDEAAVARYAKDDAVKLRQLDNAVERHEAQLRERRRQLQDEVAVMYSVQLELNRVATDYRRQHKERGDLINEWERVVKEIRERDNSIRAAAQQYAEGAEWIEQRRVALKKLHDDYDAARAEEALMQAGIEEREHRAEKSRQTRSSLETHVTGLENEVETIREELGRSIKERNNARIRLEQSKAAVRDKTAAHQRLTAKRDDLKEQKSSVYSKGADLSTQLATIGRLFKEAQDAEKQMDKETEMLKKENFTMSERLKEVRREQSDLLAEISGGQLQAQNLRTKIGQLDGQYFAQQQVLYGVEFSVQQMQRKVNRAKGERSLDERNKLHEKIAALQNTLNDLTKQQRAMETQVKRVREETWHANVELERLTSEKKVAGEKLLQLSLGCDSCTAELTKLRKQHEEKLVLVDTQELQLQDLKRTLHQRNGELGTLAERKRQLTCDIAERLSEIAVHHDMMKMEAKLVEEQRRRLVSDLRERQKALVGLRNRYDVQLVRLDPEKANWTPAQVVMEAAREREDLQLRGDTLDARVSRMEREMAKLKRTLDVIRASNSNYRHMFDPVPESHDMVKMRIALQQQQRDLKAAVSRRVMELNDYQQVMESKEQDLRQTLEKKERARATVENLQQACEQVHEGIMQARETVIRYTQTIQKASANVAPEVVADVELQENREMFNSALGRLLQLAQQHGDEVRHHVQTLLASRFVVE
Protein: Uncharacterized protein (Q387T0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDFRTIRQLVAVAEELYACGHSLHAFATLNALLERGTTIPRWYWGEEIYIRVRAAEMLLESDQLSGASEAARLDLVHSVLAPVFSRRFFERVTMEPIVWEKNNDASNGSIHCNGTSAGITASRVTRGRKGGGPRRGKGQHKECRDKEENEEREADNGNVVPIALVCRAYALNAAVHRRWLRYAQAIKLLETAQHWCSIVFAALPRAPQRLEGTDNVEKQEYEERHCCEAYLAAELCRVYYAQLMTTLGTAADGHLSNAVALHQTRRQALDGLLRTAKEYPKFVNSHSVSSIKTEKRCSAQCLSSAENPFSTRAAARLLGHYCCCALAFDYRLTDVVRQLEQCESLFGHSRELSYMRQLLTAAHHGPQAVTAIRNEPCLKRSRDELENGVDVRVGWVSDGVLNALETYITLYLAVGTGENVEHNKASAEGECNVDVKRVFHTTMERIDEQMTLLTTAASCGSKEKLLSPTLLCSSPSSNIRFLVILKCATRLTLICHSLSQLYVGEAILHLSQLRRYMEVFTKDTQRLSAYYHLLAAQTAAMLSLRHIPGTLMTPNDRSRVAGGSDNAEQAGTYSNHGSFTVEKNDMEDTAGFDVGLPYAHIRAAEAVAAHSVQPCNPSFKLLVSLMKGALLQHASHVGATLQLVNGGFTVSPLPINQRRRCAAAFEDIIDALRLSEAKTNVKEEEMGRGALAKAEFEEALQCAWNVDNRLLLLLMRGLLTLTEGKDGHTANLFFTEATRQALSCFGTKSSITAECLHRLSVARRDCEQVQLLPPDPSSVSPVLFGSLQELLDHTDIVVGSAQRTFSIAAQLASYGNRAVMLHCVSSAGIPTEQEMWSQIVSEWDSEVHHVCTTFRGDLIHALSL
Protein: Tektin (E7F7G5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000256|RuleBase:RU367040}.
Interaction partners:
- Tektin 2
- Sperm-associated antigen 8
- CD164 sialomucin-like 2.
- EF-hand domain
- EF-hand domain-containing family member C2
- F-box protein 36b.
- Protein Flattop
- Piercer of microtubule wall 2 protein
- Cilia and flagella-associated protein 52.
- EF-hand domain family, member B
Sequence:
MELIGSTQMATYTRPKTSHFLPAISTTASSYRSHQPPLSLNQNSNMPWRTNSYYRSGSAIPTLSALQRDNLELVRAKTMFYPSNRTALSTRYMPEDWYKSNQSNYRESESSRNSAERLRRDTIRLIQDKEQLTRRTQDTTSKNIGERLNDISFWRSEINHEIDNMVTEISALSDVKRRLERALAETEGPLQVAQECLFHREKRMSIDLVHDDVEIDLIKEVDVIKSCQERMRRHLERAVAQLAANRAAQHELERDLSDKVTAQRIDDRCHHLRNTSDGISYYRGIDRLDPSISLPDSWSKFTDDNILHSQSERAASHKLRDEIEILLNATSNEMWNQFNSVNVSFTNRISETADTKNNLQTHLAKTLQEIYQTEMLIEALKKAIRDKENPLKVAQTRLEERTRRPNVELCRDNPHHRLITEVREIEDTIHKLRDRLMEAENTLQTLVKTKITLEHDLSIKANSLFLDQEKCMSMRKSFPSTPRLVGFT
Protein: Pumilio domain-containing protein 5 (Q20757)
Organism: Caenorhabditis elegans
Function: RNA-binding protein that binds to the consensus sequence 5'-CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17234175, ECO:0000269|PubMed:18695046}. Cytoplasm, P-body. Note=Localizes to perinuclear and cytoplasmic P granules. {ECO:0000269|PubMed:17234175, ECO:0000269|PubMed:18695046}.
Interaction partners:
- BTB domain-containing protein
- glutamine synthetase
- glutamine synthetase
- PUM-HD domain-containing protein
- EF-hand domain-containing protein
- Inactive protein-tyrosine phosphatase egg-5
- RNA-binding protein pos-1
- Pumilio domain-containing protein 7
- EGF-like domain-containing protein
- Chondroitin proteoglycan 3
Sequence:
MSDSTGRINSKASDSSSISDHQTADLSIFNGSFDGGAFSSSNIPLFNFMGTGNQRFQYSPHPFAKSSDPCRLAALTPSTPKGPLNLTPADFGLADFSVGNESFADFTANNTSFVGNVQSNVRSTRLLPAWAVDNSGNIRDDLTLQDVVSNGSLIDFAMDRTGVKFLERHFPEDHDNEMHFVLFDKLTEQGAVFTSLCRSAAGNFIIQKFVEHATLDEQERLVRKMCDNGLIEMCLDKFACRVVQMSIQKFDVSIAMKLVEKISSLDFLPLCTDQCAIHVLQKVVKLLPISAWSFFVKFLCRDDNLMTVCQDKYGCRLVQQTIDKLSDNPKLHCFNTRLQLLHGLMTSVARNCFRLSSNEFANYVVQYVIKSSGVMEMYRDTIIEKCLLRNILSMSQDKYASHVVEGAFLFAPPLLLSEMMDEIFDGYVKDQETNRDALDILLFHQYGNYVVQQMISICISALLGKEERKMVASEMRLYAKWFDRIKNRVNRHSGRLERFSSGKKIIESLQKLNVPMTMTNEPMPYWAMPTPLMDISAHFMNKLNFQKNSVFDE
Protein: Kelch-like protein 25 (Q8R2P1)
Organism: Mus musculus (Mouse)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis. BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells.
Interaction partners:
- Cullin-3
- Ectoderm-neural cortex protein 1
- Kelch repeat and BTB domain-containing protein 8
- Kelch-like protein 13
- Kelch-like protein 42
- Kelch-like protein 41
- Kelch-like protein 40
- Kelch-like protein 9
- E3 ubiquitin-protein ligase RBX1
- Kelch-like protein 7
Sequence:
MSVSVHETRKSRSSTGSMNISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKAHLPLLLRNVRLALLPSDCLKNAVSGEALLMADECTKLILDEAFRCKTKILLNDGVVTSPFARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGIFPASPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCFDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEYTAASAYRFDCETNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA
Protein: RNA polymerase sigma-E factor (Q9KPA6)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Interaction partners:
- Anti-sigma-E factor RseA
- Sigma-E factor regulatory protein RseB
- Transcriptional activator, putative
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit beta
- Uncharacterized protein
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit omega
- Sigma-E factor regulatory protein RseC
- Flagellum-specific ATP synthase
Sequence:
MNEQLTDQVLIERVQNGDKQAFNLLVLRYQNKVCNLISRYVSNSGDVADVAQEAFIKAYRAIPTFRGESAFYTWLYRIAVNTAKNHIVAQSRRPPASDVDAEEAEFYEGGDALKELSNPENITLSKELKKTVFDAIDALPDDLKTAMTLRELDGLSYEEIAEVMDCPVGTVRSRIFRAREAVEKKIKPLL
Protein: Ferredoxin-type protein NapF (P0AAL0)
Organism: Escherichia coli (strain K12)
Function: Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm. Is not involved in the electron transfer from menaquinol or ubiquinol to the periplasmic nitrate reductase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17074894}. Note=Loosely attached to the inner side of the membrane. {ECO:0000269|PubMed:17074894}.
Interaction partners:
- Periplasmic nitrate reductase
- Chaperone NapD
- Ferredoxin-type protein NapH
- Periplasmic nitrate reductase, electron transfer subunit
- Cytochrome c-type protein NapC
- Ferredoxin-type protein NapG
- Formate dehydrogenase H
- Cytochrome c-type protein TorY
- NADH-quinone oxidoreductase subunit E
- Cytochrome c-type protein TorC
Sequence:
MKIDASRRGILTGRWRKASNGIRPPWSGDESHFLTHCTRCDACINACENNILQRGAGGYPSVNFKNNECSFCYACAQACPESLFSPRHTRAWDLQFTIGDACLAYQSVECRRCQDSCEPMAIIFRPTLSGIYQPQLNSQLCNGCGACAASCPVSAITAEYLHAH
Protein: Hexokinase-2 (EC 2.7.1.1) (P93834)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:12953116, ECO:0000269|PubMed:14671022}; Single-pass membrane protein {ECO:0000269|PubMed:12953116, ECO:0000269|PubMed:14671022}.
Interaction partners:
- Glucose-6-phosphate isomerase, cytosolic
- Glucose-6-phosphate isomerase 1, chloroplastic
- Phosphoglucomutase, chloroplastic
- Probable phosphoglucomutase, cytoplasmic 2
- Probable phosphoglucomutase, cytoplasmic 1
- Phosphomannomutase
- Fructose-1,6-bisphosphatase, cytosolic
- Mannose-6-phosphate isomerase 2
- Fructose-1,6-bisphosphatase 1, chloroplastic
- Mannose-6-phosphate isomerase 1
Sequence:
MGKVAVATTVVCSVAVCAAAALIVRRRMKSAGKWARVIEILKAFEEDCATPIAKLRQVADAMTVEMHAGLASEGGSKLKMLISYVDNLPSGDETGFFYALDLGGTNFRVMRVLLGGKHDRVVKREFKEESIPPHLMTGKSHELFDFIVDVLAKFVATEGEDFHLPPGRQRELGFTFSFPVKQLSLSSGTLINWTKGFSIDDTVDKDVVGELVKAMERVGLDMLVAALVNDTIGTLAGGRYTNPDVVVAVILGTGTNAAYVERAHAIPKWHGLLPKSGEMVINMEWGNFRSSHLPLTEYDHSLDVDSLNPGEQILEKIISGMYLGEILRRVLLKMAEEAAFFGDIVPPKLKIPFIIRTPNMSAMHSDTSPDLKVVGSKLKDILEVQTSSLKMRKVVISLCNIIASRGARLSAAGIYGILKKIGRDATKDGEAQKSVIAMDGGLFEHYTQFSESMKSSLKELLGDEVSESVEVILSNDGSGVGAALLAASHSQYLELEDDSETS
Protein: Glycinin G5 (Glycinin 11S G5) (Glycinin A3B4) (allergen Gly m 6) [Cleaved into: Glycinin A3 subunit; Glycinin B4 subunit] (P04347)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Glycinin is the major seed storage protein of soybean. Glycinin basic peptides (GBPs), and, to a lower extent, glycinin exhibit antibacterial activity against Gram-negative and Gram-positive bacteria (e.g. L.monocytogenes, B.subtilis, E.coli and S.enteritidis) by forming pores and aggregating in transmembranes, leading to membrane permeability and, eventually, cell death.
Subcellular location: Vacuole, aleurone grain. Endoplasmic reticulum {ECO:0000269|PubMed:29348620}. Protein storage vacuole {ECO:0000269|PubMed:29348620}. Note=Hexamers are assembled in the endoplasmic reticulum and later sorted to the protein storage vacuoles (PubMed:29348620). Cotyledonary membrane-bound vacuolar protein bodies. {ECO:0000269|PubMed:29348620}.
Interaction partners:
- 2S seed storage albumin protein
- Basic 7S globulin
- Albumin-1
- Basic 7S globulin 2
- Beta-conglycinin alpha subunit 1
- Kunitz trypsin inhibitor
Sequence:
MGKPFFTLSLSSLCLLLLSSACFAITSSKFNECQLNNLNALEPDHRVESEGGLIETWNSQHPELQCAGVTVSKRTLNRNGSHLPSYLPYPQMIIVVQGKGAIGFAFPGCPETFEKPQQQSSRRGSRSQQQLQDSHQKIRHFNEGDVLVIPLGVPYWTYNTGDEPVVAISPLDTSNFNNQLDQNPRVFYLAGNPDIEHPETMQQQQQQKSHGGRKQGQHRQQEEEGGSVLSGFSKHFLAQSFNTNEDTAEKLRSPDDERKQIVTVEGGLSVISPKWQEQEDEDEDEDEEYGRTPSYPPRRPSHGKHEDDEDEDEEEDQPRPDHPPQRPSRPEQQEPRGRGCQTRNGVEENICTMKLHENIARPSRADFYNPKAGRISTLNSLTLPALRQFGLSAQYVVLYRNGIYSPDWNLNANSVTMTRGKGRVRVVNCQGNAVFDGELRRGQLLVVPQNPAVAEQGGEQGLEYVVFKTHHNAVSSYIKDVFRVIPSEVLSNSYNLGQSQVRQLKYQGNSGPLVNP
Protein: Ras-related protein RABA2d (AtRABA2d) (Q9FIF9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intracellular vesicle trafficking and protein transport.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18239134}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:18239134}; Lipid-anchor {ECO:0000305|PubMed:18239134}. Note=During cytokinesis located to the growing margins of the cell plate.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta 1
- Kinesin-like protein KIN-14E
Sequence:
MAHRVEQDYDYLFKIVLIGDSGVGKTNILSRFTRNEFCLESKSTIGVEFATRTLQVEGKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDITKRQTFDNVLRWLRELRDHADSNIVIMMAGNKADLNHLRSVAEEDGQTLAETEGLSFLETSALEATNVEKAFQTVLAEIYHIISKKALAAQEAAAANSAIPGQGTTINVEDTSGAGKRGCCST
Protein: Anon1A3 (Q9U4Q8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
GVENLPSVTEAKQNHVDEVKPISEEPGNSSEEVPKAEEPLKSSGETSENGAATETAAAPKEPASVMDVDEDETLVENTPSANKEKALDDEKEPEQKSEEHAAAVLESKEQNEPAKEPTPEPMEVDGSSKGSSDTAQVDTPAIENVSAAPETEAAAKTTESSNDVVEVATEGKETVLEVPAAEPKEAESTVESAEELTETSTVVVTEPKEAASSEEEPSKVVDSAEPKEAESNTDESATPVPIDVSTAPASNDVSKPLEIDTTLVKTADSPAKEPQEICEVKKAEINVNGEPKIVNSSAEVGENAAPKVCN
Protein: Nitrogen regulatory protein P-II homolog (Protein PII-like) (Q9ZST4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Participates in sensing carbon and organic nitrogen status and regulates some steps of primary carbon and nitrogen metabolism. Required for nitrite uptake in chloroplasts and regulates arginine biosynthesis through interaction with acetylglutamate kinase (NAGK) in chloroplasts. Regulates fatty acids synthesis in chloroplasts by interacting with the acetyl-CoA carboxylase complex and inhibiting acetyl-CoA carboxylase (ACCase) activity.
Subcellular location: Plastid, chloroplast {ECO:0000255|PROSITE-ProRule:PRU00675, ECO:0000269|PubMed:16377628, ECO:0000269|PubMed:9811909}.
Interaction partners:
- Acetylglutamate kinase, chloroplastic
- Putative ammonium transporter 1 member 5
- Ammonium transporter 1 member 4
- Ammonium transporter 1 member 3
- Ammonium transporter 1 member 2
- Ammonium transporter 1 member 1
- Ammonium transporter 2
- Probable amino-acid acetyltransferase NAGS2, chloroplastic
- At2g22905
- Probable amino-acid acetyltransferase NAGS1, chloroplastic
Sequence:
MAASMTKPISITSLGFYSDRKNIAFSDCISICSGFRHSRPSCLDLVTKSPSNNSRVLPVVSAQISSDYIPDSKFYKVEAIVRPWRIQQVSSALLKIGIRGVTVSDVRGFGAQGGSTERHGGSEFSEDKFVAKVKMEIVVKKDQVESVINTIIEGARTGEIGDGKIFVLPVSDVIRVRTGERGEKAEKMTGDMLSPS
Protein: Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) (P08651)
Organism: Homo sapiens (Human)
Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Subcellular location: Nucleus.
Interaction partners:
- Nuclear factor 1 B-type
- Neurofibromin
Sequence:
MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQAQSWYLG
Protein: Starch synthase 3, chloroplastic/amyloplastic (AtSS3) (EC 2.4.1.21) (Soluble starch synthase III) (F4IAG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the synthesis of glycan chains within amylopectin in leaves. May play a regulatory role in the control of starch accumulation in plastids.
Subcellular location: Plastid, chloroplast. Plastid, amyloplast {ECO:0000305}.
Interaction partners:
- 1,4-alpha-glucan-branching enzyme 2-2, chloroplastic/amyloplastic
- 4-alpha-glucanotransferase DPE2
- 1,4-alpha-glucan-branching enzyme 3, chloroplastic/amyloplastic
- 1,4-alpha-glucan-branching enzyme 2-1, chloroplastic/amyloplastic
- 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic
- Ornithine transcarbamylase, chloroplastic
- Granule-bound starch synthase 1, chloroplastic/amyloplastic
- Isoamylase 3, chloroplastic
- Isoamylase 2, chloroplastic
- Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic
Sequence:
MISYFLNQDFSRKKQGRMAASGPKSSGPRGFGRRTTVGSAQKRTQKKNGEKDSNATSTATNEVSGISKLPAAKVDVQKQSSVVLNERNVLDRSDIEDGSDRLDKKTTDDDDLLEQKLKLERENLRRKEIETLAAENLARGDRMFVYPVIVKPDEDIEVFLNRNLSTLNNEPDVLIMGAFNEWRWKSFTRRLEKTWIHEDWLSCLLHIPKEAYKMDFVFFNGQSVYDNNDSKDFCVEIKGGMDKVDFENFLLEEKLREQEKLAKEEAERERQKEEKRRIEAQKAAIEADRAQAKAETQKRRELLQPAIKKAVVSAENVWYIEPSDFKAEDTVKLYYNKRSGPLTNSKELWLHGGFNNWVDGLSIVVKLVNAELKDVDPKSGNWWFAEVVVPGGALVIDWVFADGPPKGAFLYDNNGYQDFHALVPQKLPEELYWLEEENMIFRKLQEDRRLKEEVMRAKMEKTARLKAETKERTLKKFLLSQKDVVYTEPLEIQAGNPVTVLYNPANTVLNGKPEVWFRGSFNRWTHRLGPLPPQKMEATDDESSHVKTTAKVPLDAYMMDFVFSEKEDGGIFDNKNGLDYHLPVVGGISKEPPLHIVHIAVEMAPIAKVGGLGDVVTSLSRAVQELNHNVDIVFPKYDCIKHNFVKDLQFNRSYHWGGTEIKVWHGKVEGLSVYFLDPQNGLFQRGCVYGCADDAGRFGFFCHAALEFLLQGGFHPDILHCHDWSSAPVSWLFKDHYTQYGLIKTRIVFTIHNLEFGANAIGKAMTFADKATTVSPTYAKEVAGNSVISAHLYKFHGIINGIDPDIWDPYNDNFIPVPYTSENVVEGKRAAKEELQNRLGLKSADFPVVGIITRLTHQKGIHLIKHAIWRTLERNGQVVLLGSAPDPRIQNDFVNLANQLHSSHGDRARLVLTYDEPLSHLIYAGADFILVPSIFEPCGLTQLIAMRYGAVPVVRKTGGLFDTVFDVDHDKERAQAQVLEPNGFSFDGADAPGVDYALNRAISAWYDGREWFNSLCKTVMEQDWSWNRPALEYLELYHSARK