wanglab/gogpt-training-data huggingface dataset:
Protein: IgLON family member 5 precursor (Zgc:110372) (A4JYK9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- N-terminal Xaa-Pro-Lys N-methyltransferase 2
Sequence:
MSCAMLRHALALLLALLWKGPSGAQAAEFGHLPDNITVLEGESVVLRCKIDEEVTHKAWLNRSNILFTGTDKWSLDSRVSLENNNNSDFSIRIERVMVADEGPYTCSFQARNKPRTAHVYLIVQVPARIVNISQDKSVNEGEDVNLFCLAVGRPEPTITWKDFKYGLLNEGEFLEITEIKRHQAEDFECITNNGVAPPDTRKVKVTVNYPPIITDVKNMPAQVGKTAILRCEAMAVPTASFEWYRDDRRPVESDNTLKIKNEKTRSLLLFTNVTEKHFGNYTCFASNRLGASNASMLLFRPGAVYGGAASLNGRLSGVGLWFCLSISVLMKV
Protein: Ribosomal protein L18 (F8VUA6)
Organism: Homo sapiens (Human)
Subcellular location: Rough endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004427}.
Interaction partners:
Sequence:
MSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRA
Protein: UPAR/Ly6 domain-containing protein rtv (Protein retroactive) (Q9VZ21)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000255|RuleBase:RU369020}; Lipid-anchor, GPI-anchor {ECO:0000255|RuleBase:RU369020}.
Interaction partners:
- Knickkopf
- Putative inorganic phosphate cotransporter
- UPAR/Ly6 domain-containing protein bou
- chitin synthase
Sequence:
MQFTSLLLAVIFLISLVSIDGLLRRCYQCRSRGELGSCKDPFTFNATDVEQEPGVAAIPCASGWCGKVIEGGGTYAIDDYDLAIQRMCVQRGPDDNMDRCADTIYNYKKVYMCFCQGDLCNGARSWSSAPQMILITMLPLLGSWLLQRMRN
Protein: Uncharacterized protein (Q8IIC0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Transcription initiation factor TFIID subunit 7, putative
- Histone H4
Sequence:
MADNNLDKNESDSSCINASDEQKSSEEKDNLGEASVVSNVNENNSSFFTKCFSKIVNFGNNTQENNIPVAHEENNNEDREYNTNESNCNRYDDEEDKKVENFDNNNINNNYLKGDGEKNIHEGGDVHTDFNNEEMINAISNYNKNELNLNRGEIYLNDNEYSFISYIILSSEFRFYPIEETKKKKRRDTLKIDDTITITDTKRIKFDNNNNNNNKIEIRKKENVTDIDADKGSNNHMNEKQVVNNSEDILKKEDEEEENLKKEGGDLLIKGNNVDKVLLDDIDIEKVRSYDKIMDAEERDKLELFDEILIHIKRNFYEKILNIETNFKNLENQIEDNHSFHFRCIIEKLKNRKYDNILYIYNDIYLYHNNLLFLSKPSSYTWMKLHELSTQITNTISDIHHKKYMQKPNRKLYHIDKEEKEKKEKKKEVLKDHEKMEYCINEEEKLAFQLLLSKLNQDTHFELFRKFKNKAVWKTLEGGEIELDDKLTRADVFREMYNWCKFQLEMKNKQSELSDSESDSSKDSY
Protein: 1-carboxybiuret hydrolase subunit AtzE (EC 3.5.1.131) (Q936X3)
Organism: Pseudomonas sp. (strain ADP)
Function: Hydrolyzes 1-carboxybiuret to urea-1,3-dicarboxylate and NH(3).
Interaction partners:
Sequence:
MKTVEIIEGIASGRTSARDVCEEALATIGATDGLINAFTCRTVERARAEADAIDVRRARGEVLPPLAGLPYAVKNLFDIEGVTTLAGSKINRTLPPARADAVLVQRLKAAGAVLLGGLNMDEFAYGFTTENTHYGPTRNPHDTGRIAGGSSGGSGAAIAAGQVPLSLGSDTNGSIRVPASLCGVWGLKPTFGRLSRRGTYPFVHSIDHLGPLADSVEGLALAYDAMQGPDPLDPGCSASRIQPSVPVLSQGIAGLRIGVLGGWFRDNAGPAARAAVDVAALTLGASEVVMWPDAEIGRAAAFVITASEGGCLHLDDLRIRPQDFEPLSVDRFISGVLQPVAWYLRAQRFRRVYRDKVNALFRDWDILIAPATPISAPAIGTEWIEVNGTRHPCRPAMGLLTQPVSFAGCPVVAAPTWPGENDGMPIGVQLIAAPWNESLCLRAGKVLQDTGIARLKC
Protein: Protein mes-1 (Maternal-effect sterile protein 1) (G5EBL2)
Organism: Caenorhabditis elegans
Function: During early embryogenesis, controls asymmetric cell division and the asymmetric localization of P granules of germline precursor P2 and its descendant P3. Probably upstream of tyrosine kinase src-1, plays a role in endoderm development by controlling spindle orientation during EMS blastomere cell division. Controls EMS spindle orientation probably by promoting lin-5 and gpr-1/2 enrichment at, and let-99 exclusion from the junction between P2 and EMS cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11003841, ECO:0000269|PubMed:12110172}; Single-pass type I membrane protein {ECO:0000305}. Note=Localizes at the site of contact between EMS and P2 cells in the 4-cell stage embryo, between P3 and E cells in the 12-cell stage embryo and between P4 and Ep cells in the 26-cell stage embryo. {ECO:0000269|PubMed:11003841, ECO:0000269|PubMed:12110172}.
Interaction partners:
- Tyrosine protein-kinase src-1
- Protein meg-2
- Protein let-99
- Protein mom-2
Sequence:
MKIHHFLTLLCTFLPLTTTALTNSTPLSLLGPCYKRCVTKFGETKEQLTNAETISLEYDVSNNTEFSLCKLGCNSHEYTDLNLAAFRYGQLAYQKILTTVEDVPTRGTVLNDVFIVCLDTSFMPSNNSAPSAKRLLSGTVLLVLDEDVAKADNVFLIEVLARNADKSAVQVISQQWCYSSNCNITFNAPTEVSSFDVRLRVSTFDSNGQVGGINFSKWHNINQILTKTFVDMSLKSVVWKAEKAAANFVFNLTASDHVPACSLQMIYRSSLSSELLHRNFYLDHTLEVFVNNLDFDKIYTMQLAPSGTHDRSTPSLASAVIEIPPCRHLVDDYSMCAPPPVSSLSYNWNLSPTSEYELLIKWKLLNYMDGLNVTEELSIPVAYFLLNAHPLITANNEQCEKYEKIRRVVSYGLRELVFHVPDTDCNYEVEMTAVDTNQRISEVKKIQVFRFNVPPYVSFLQASDIPTSVELMAVVLATSAIFALIALFLLYRKRKRDKKARFQMYKDAEAGVSYDYVATTESLGSVVQIRSTNFRFEPVENIDGNIEAALAQQQKFEGGTMNSMFRTYYNLDHPVKVPAHMAEASSDEDNGYENIRYSYFGSELSDDVFEEDIYMTHKSLSIYCQDSPLTTPMAPIAPYEHFDDIPSHQYRNFQVHNFNERIEKQAYWLMATVVDVVRRELYSLKVPKDYTPETISAMRKELEFLRTLAPHGNCRRFEGVVIGRWDDLPRQVIGILIENTRGGTLRNYIAAVGSVFRNCSLATDHDSFASQQDMNSTQHPFDKLSTEADENNSKKVKIQEITDSLSIRFCQFAEQVSSALEHLHSAGSVHTRVTTLNIYLLHNYSDPFDMLPDQVVKLGNFGFAVQNSEDVVLDDNLQPPEVIKGEKYEARGDIWQFGLCLAEMCSLGDLEQSEVGTLKSGHDTFKNLPSTQVLRDAAKRCLSARTRPSASDLCGVFKSVNVAATV
Protein: Guanine nucleotide binding protein gamma 10 (Q45QK2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}.
Interaction partners:
Sequence:
VSQAAAELQQYCIQNACKDALLLGVPAGSNPFREPRSCALL
Protein: High molecular weight rhoptry protein 2 (C0H571)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Host cell membrane {ECO:0000269|PubMed:28252383, ECO:0000269|PubMed:35393572}; Single-pass membrane protein {ECO:0000255}. Host cell membrane {ECO:0000269|PubMed:28252383, ECO:0000269|PubMed:35393572}; Peripheral membrane protein {ECO:0000269|PubMed:28252383}. Parasitophorous vacuole membrane {ECO:0000269|PubMed:35393572}; Single-pass membrane protein {ECO:0000255}. Host cytoplasm {ECO:0000269|PubMed:28252383}. Cytoplasm {ECO:0000269|PubMed:35393572}. Cytoplasmic vesicle, secretory vesicle, rhoptry {ECO:0000269|PubMed:17175193, ECO:0000269|PubMed:28252383, ECO:0000269|PubMed:35393572}. Note=Export to host cytosol is mediated by the Plasmodium translocon of exported proteins (PTEX) complex. {ECO:0000250|UniProtKB:Q8I060}.
Interaction partners:
- High molecular weight rhoptry protein 3
- Cytoadherence linked asexual protein 3.2
- Cytoadherence-linked asexual protein 3.1
- Surface protein P113
Sequence:
MIKVTIFLLLSIFSFNLYGLELNEKVSIKYGAEQGVGSADSNTKLCSDILKYLYMDEYLSEGDKATFEKKCHNVIGNIRNTFSNKNTIKEGNEFLMSILHMKSLYGNNNNNNAGSESDVTLKSLYLSLKGSQNTEGESEVPSDDEINKTIMNFVKFNKYLLDNSNDIKKVHDFLVLTSQSNENLLPNKEKLFEQIVDQIKYFDEYFFASGGKIKVKKGYLKYNFLDIYKQPVCSAYLHLCSRYYESVSIYIRLKKVFNGIPAFLDKNCRKVKGEEFKKLMDMELKHNHIVERFDKYIISDDLYYVNMKVFDLKNVDKIQVSKIDDINNLNIYEHKETMHLSAKNLSRYIDIKKELNDEKAYKQLMSAIRKYVTTLTKADSDITYFVKQLDDEEIERFLIDLNFFLYNGFLRITEDKHLINADDVSPSYINLYRSNNIVALYILKTQYEENKLSEYRAHKFYRRKRVSNITNDMIKKDFTQTNALTNLPNLDNKKTTEYYLKEYENFVENFQPDLHDIMKLQLFFTMAFKDCNVNQNFTETSKKLWFDLLYAYDKFGWFYIHPNEVINSINKTDFVRHVLVSRNFLLKNNDQLTFLETQVAKIVEIINLSLEVDKSPDSLDFSIPMNFFNHKNGYHVMNDDKLKLLTSYEYIDSIANNYFFLSEYKNDVFRTGNNFKLYFNLPNIYSLAYQLFNELAININVITNVPLKKYLKYNASYAYFTLMNMIGKNHDIYSKGSRFVYASYILGLVFFIESHIDIARLKPKDFFFMKQSLPIIDHVYHKDLKTLKKNCTLLTDFMKINKNSQNYSLTHTEEMIKILGLLTVTLWAKEGKKSVYYDDDVSLYRKLMVSCVFNGGETIQEKLANNIEKSCDISQYGIKSKNLKDMIDINLSIHKWNPAEIEKLAYSFVLSCKMQKLMYKPMNVEKLPLEDYYKLSLAPDMVKTYHCYKLGKQAAELLESIILKKKFVRFRVTDAIDVYDFFYIKKVLSSRIKKEYNEFLQDKRAFEKKELETILNNSPFSEEQTMKLINSYECHWFTSYENFRILWMHASSNLGTGTYLKNFFSELWQNIRFLFKSKLKIRDMEYFSGDISQMNLLDYYSPMVHSESHCQEKMQVLFITLRDSKEENRSEIAQKVKSAYYQCKLDYYKNHHSDFIHRIHPNDFLNNKVYVLKQPYYLMSNVPLNNPKKVSRLFVTEGTLEYLLLDKINIPECFGPCTKLHFNKVVIKESKQRIYDMTINNALVPEIQPYNRRKYMTIYINEAYIKNIVSDALTSEEIKRHDIQKGNIKICMGKSTYLTEPILTEEHFNLTHKPVYDFSSVKHNLKVFHMKNEHLVSEDPNDDCFINYPLATINLDISDPYKEISEDLIKNLYILKSS
Protein: Glucan endo-1,3-beta-D-glucosidase (Endo-1,3-beta-glucanase) (EC 3.2.1.39) (Laminarinase) (Q47N06)
Organism: Thermobifida fusca (strain YX)
Function: Cleaves internal linkages in 1,3-beta-glucan. May contribute to biomass degradation by hydrolyzing the 1,3-beta-linked plant polymer callose that is present in decomposing plant tissue.
Subcellular location: Secreted {ECO:0000269|PubMed:17115704, ECO:0000269|PubMed:19435780}.
Interaction partners:
Sequence:
MSHASRRRWRRATTSAATAALLCGALLTFPSAPAAAQVRLGSGSYTTVLPPGASGPSDHTGAPVAPKVTADFTQPVVTNDWWSSLIFQRYPGNPYGENLYAHPLSFKAQAHGLEVGYPDTPELVADGLKYQYTHSPDFVLGIHGLNAPAAKVAGYSDWTVTADLSDGTRQLRTTIGQGLPFVYADVSGGPIRVEFTAPPTVWRRSGNAVGVTVNGHHYALFAPSGTTWSESDTVFTADVGGSGYASVALLPSPDDFDRYAPYAYSFVTSTTLTYDYDPASATLTSTYRVTTEAREGTAQGTLLALYPHQWKETTTALTDLSYASPRGPMRVVEGDRFTTELTTHGILPSLPTVDSADHQRLRALIDAELHASDPWKGASDTYWTGKALGRLAQLVPIADSIGYTAGRDALLDLLKNKMEDWLTADGPGDNAQFYYDDQWDTLIGFPASFGSNTELNDHDFHYGYFITAAATIARYDRSWISEERWGPMVTTVLRDANNPDRDDERFPWLRSFSPYAGHGWASGHAGFASGNNQESSSEAMHFAASAALLGSLIGDEELRDLGVYLHTTQASAMRRYWQNADGDAFPAGYSHDVVGMVWSDGGDHRIWWDGTPEELYGINYLPITAGSLYLGHDPEHAAAMHQSLVTRLGRQPQVWRDIHWAHQALSDPDAALAAFEAQWQSYEPESGSSKAHTYQWLSTLAEFGTVDTSVTADTPHYAVFRDGDRRTYVAFNPTGQPLTVTFSDGTTLTVPPGQLATG
Protein: Blood group Rh(D) polypeptide (Erythrocyte membrane glycoprotein Rh30) (CD antigen CD240D) (Q8CF94)
Organism: Mus musculus (Mouse)
Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q02161}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ammonium transporter Rh type A
- Band 3 anion transport protein
- Glycophorin-A
- Leukocyte surface antigen CD47
- Protein 4.2
- Kell blood group glycoprotein homolog
- Ankyrin-1
- Paired box protein Pax-3
Sequence:
MGSKYPRSLRCCLPLWALELQTAFSLLFCFFIPHDTAQVDHRFMASYQVLRNLTLMAALGFGFLSSSFRRHSWSSVAFNLFMLALGVQGTILLDHFLGQVLQWNKINNLSSIQIATMSTLPVLISAGAVLGKVNLVQLTVMVLMEAMAFGAIRFADEKVFKMTEHIIMMHGHVFGAYFGLTVAWWLSRSLPRRVGENAQTEKVQMATSSSLFAMLGTLFLWIFWPAINSALLEGTKKRNAVFNTYYALAVSAVTATSMSALSHPQGKINMVHIHNAVLAGGVAVGAPGCLISSPWISMVLGLIAGLISIWGAKCPRACLNHMLQNSSGIHYTFGLPGLLGALTYYCLQIVTEPKSSDLWIITQTVTHIGALSFAVAMGMVTGLLTGCLLSVRVWRAPHAAKYFDDQTFWEFPHLAVGF
Protein: SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) (Q13573)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD.
Subcellular location: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
Interaction partners:
- U2 small nuclear ribonucleoprotein A'
- Crooked neck-like protein 1
- Pre-mRNA-processing-splicing factor 8
- Pre-mRNA-splicing factor CWC22 homolog
- 116 kDa U5 small nuclear ribonucleoprotein component
- Pre-mRNA-processing factor 17
- Small nuclear ribonucleoprotein Sm D2
- Pre-mRNA-processing factor 19
- Pleiotropic regulator 1
- Pre-mRNA-splicing factor SYF2
Sequence:
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSGSDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q59N42)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- WD-repeat containing protein
- Type 1 protein phosphatase-activating protein
- Endoribonuclease YSH1
- Protein CFT1
- Polyadenylation factor subunit 2
- Cleavage polyadenylation factor subunit
- Cleavage and polyadenylation specificity factor subunit 2
- RNA-processing protein
- Poly
Sequence:
MSNNIEDDSISVDNIVDRLLEVRGSRPGKQVTLTENEIRFLCTKAREIFIQQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPADKKPRYAPANVANNRPGANQRKPKKAVK
Protein: Glutathione peroxidase (EC 1.11.1.9) (C0HLL8)
Organism: Lactiplantibacillus plantarum (Lactobacillus plantarum)
Function: Glutathione peroxidase which may protect the cell from oxidative damage.
Interaction partners:
Sequence:
TELSGAPLDLYQYRGQVLLIPQFTGLLYQKSQQEGDVVDGLPSHQFHQY
Protein: E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (E-cadherin binding protein E7) (RING-type E3 ubiquitin transferase Hakai) (Q9JIY2)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q75N03}. Nucleus, nucleoplasm {ECO:0000269|PubMed:29547716}. Cytoplasm {ECO:0000269|PubMed:29547716}. Note=Mainly nuclear with some fraction located in the cytoplasm (PubMed:29547716). ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus (PubMed:29547716). {ECO:0000269|PubMed:29547716}.
Interaction partners:
- Pre-mRNA-splicing regulator WTAP
- RNA-binding protein 15
- Zinc finger CCCH domain-containing protein 13
- N
- N
- Protein virilizer homolog
- Putative RNA-binding protein 15B
- Cadherin-1
- RNA N
- YTH domain-containing protein 1
Sequence:
MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQASKVKPAPRTQRTVSRMPAKAPQGDEEGFDYNEEQRYDCKGGELFGNQRRFPGHLFWDFKINILGEKDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTDIPDRFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSSSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRMQGPPSQTPLPGPHHPDQTRYRPYYQ
Protein: Succinate dehydrogenase assembly factor 2-A, mitochondrial (SDH assembly factor 2-A) (SDHAF2-A) (Q4V5I9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Subcellular location: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03057}.
Interaction partners:
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
Sequence:
MLRQLRLTMDISGWIFLPWRRSMSNMKDSPPPPPPLASTFNDVIVDYEDPDYLPLPEYPVRPNEPLETRKQRLLYQSRKRGMLENDLLLSTFAAKHLQNFSAEQTAQYDQLINGVSNDWDIYYWATEVKPTPKEYDTEIMGLLKEHVKNAERVTRLRQPDLNI
Protein: Glutathione S-transferase U5 (AtGSTU5) (EC 2.5.1.18) (AtGSTU1) (GST class-tau member 5) (Glutathione S-transferase 103-1A) (P46421)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC). May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase F8, chloroplastic
- Glutathione S-transferase DHAR2
- Glutathione S-transferase F2
- Glutathione S-transferase F10
- Glutathione S-transferase F11
- Glutathione S-transferase DHAR3, chloroplastic
- AT3g25910/MPE11_6)
- Glutathione synthetase, chloroplastic
- Glutathione S-transferase F9
Sequence:
MAEKEEVKLLGIWASPFSRRVEMALKLKGIPYEYVEEILENKSPLLLALNPIHKKVPVLVHNGKTILESHVILEYIDETWPQNPILPQDPYERSKARFFAKLVDEQIMNVGFISMARADEKGREVLAEQVRELIMYLEKELVGKDYFGGKTVGFLDFVAGSLIPFCLERGWEGIGLEVITEEKFPEFKRWVRNLEKVEIVKDCVPPREEHVEHMNYMAERVRSS
Protein: Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) (D4AC20)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Thymidine phosphorylase
- Uridine phosphorylase
- Uridine phosphorylase
- Deoxycytidine kinase
- Uridine-cytidine kinase
- Thymidine kinase, cytosolic
- Uridine-cytidine kinase
- Thymidine kinase 2, mitochondrial
- Purine nucleoside phosphorylase
- 7-methylguanosine phosphate-specific 5'-nucleotidase
Sequence:
MAQERPSCAVEPEHVQRLLLSSREAKKSAYCPYSRFPVGAALLTGDGRIFSGCNVENACYPLGVCAERTAIQKAISEGYKDFRAIAIASDLQEEFISPCGACRQVMREFGTNWAVYMTKPDGTFVVRTVQELLPASFGPEDLQKIH
Protein: Tk-subtilisin (EC 3.4.21.-) (P58502)
Organism: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Function: Has a broad substrate specificity with a slight preference to large hydrophobic amino acid residues at the P1 position.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MKKSIALVLSIVLLAALFAVPASAGEQNTIRVIVSVDKAKFNPHEVLGIGGHIVYQFKLIPAVVVDVPANAVGKLKKMPGVEKVEFDHQAVLLGKPSWLGGGSTQPAQTIPWGIERVKAPSVWSITDGSVSVIQVAVLDTGVDYDHPDLAANIAWCVSTLRGKVSTKLRDCADQNGHGTHVIGTIAALNNDIGVVGVAPGVQIYSVRVLDARGSGSYSDIAIGIEQAILGPDGVADKDGDGIIAGDPDDDAAEVISMSLGGPADDSYLYDMIIQAYNAGIVIVAASGNEGAPSPSYPAAYPEVIAVGAIDSNDNIASFSNRQPEVSAPGVDILSTYPDDSYETLMGTSMATPHVSGVVALIQAAYYQKYGKILPVGTFDDISKNTVRGILHITADDLGPTGWDADYGYGVVRAALAVQAALG
Protein: Uncharacterized protein (Q382F1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHNSRSTIEMGFCSVHRRKRARADLVPLDNNPGHMRCKNHKECRQRTEVELVLCSVHNRRRSITQMKEVRKGVFECLPQHTCRGQFNDSGIQSPAPPSSNANAVASSYGIPQRGSRPQQGPREHHPAPTVSVAWAPTSSRSRHDNLVGSSDWAQVDRKTWCARHGKLTSQCELVKDCCYVCYDESTCLSTALELASDLMAKGCKELLCSKHNSLRLLEFLERTPDKLGYQCVAGHRCRGTLDSCREPVPERGAHPTRDAVSSFFI
Protein: Doublesex- and mab-3-related transcription factor B1 (Doublesex- and mab-3-related transcription factor 6) (A2A9I7)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
Sequence:
MLRAPKCSRCRNHGYLVPVKGHTGKCRWKQCICDKCYLITERQKIMAAQKVLRTQAAEEQVATVGTQGPQLPPRAPAAAATALSSSICPLPRAVPGGVGPGPTATCFLERPPQAPSPGPSTFQLGPSGRPGPSTFQPGPGAPGGLRDRSSAWLPQLMPQAPRPELCYPDQHLPVRPVPVPGPVRPVPRLPFADYGHPLRFKSDHVVGAGNPEREPFKQCPACVPVSPYQSFPLSEGQDSSSALGVPQQRGFRHVSCSPYHRSGLVSEPARDLQPTYCSPPPPPPPPPPPPLPAPPPQPQQPHFLPPGYLSALHFLPPPPPPPSPPSFSLTYDTDKENTNDQDAEAPTEPSQDSPQEQSN
Protein: Pre-mRNA-processing protein prp40 (O14176)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1 (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- U1 snRNP-associated protein usp107
- U1 snRNP-associated protein usp106
- Pre-mRNA-splicing factor cdc5
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- Pre-mRNA-processing factor 39
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein E
- Pre-mRNA-splicing factor sap145
- U1 small nuclear ribonucleoprotein usp102
- Small nuclear ribonucleoprotein F
Sequence:
MSAPPWQTSEYDETEGFTSNQEGPSAAPSKTVASDWHEVKTEDSRVYYYNSVTRKSVWEKPEELMNDFEKKLSKLAWKEYATADGKKYWYNVNTRESVWDIPDEYKAALVDEPEQQKKALSSKIKSNDNKPAVQSIQRHGPDVAAPSSQPAKDQSQQISQGSHKRTINFVQQKDKRQKRSNDYQHENYDTYEAAERAFFKFLDSHNVNPSWTWEQTVRELCDAKGYYVMKDPWHRKCAFDAYILNYLTDQSDAEKNRVTKIRKEFIEMLKSSDKIHSYTLWRTVKNEFSSHPAFNATSSETEQQQLFFEYKQKLLEDEKQLEKDRRKEALDDFCSLLRNMNFEPYTRWSVAQAKFDQDPRYTRNSNMKYLSKLDALVAFEDHVKHLEREYILDKQKQKKEKHRIERKNRDAFRALLQDLRVQKKITLRTKWKELYPIIKDDPRYLNLLGQSGSTPLDLFWDTIVDLENMYREKRNLVLDCLEVLQISVDDTSNIPEIIARLSEKLKDREESEAVTEDLIEEVVNRLRDKAIHKKAEEKRADERRIRRKIDNLRSAIKYLKPPISADASYDEIRPLISILPEFAALHSEEHRMAAFDKYIRRLREKRELEKQYQNRRGYYDVGKDESYLANSARPHSGYEDGRLEYSADLASKSNRNEINTMQDVQENSISHVTATQPAVKNIVDDAESSEEGEIR
Protein: Transcription factor bHLH140 (Basic helix-loop-helix protein 140) (AtbHLH140) (bHLH 140) (Transcription factor EN 122) (bHLH transcription factor bHLH140) (Q9M041)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- DNA-repair protein XRCC1
- DNA repair protein XRCC4
- At1g61410
- DNA polymerase lambda
- DNA ligase 4
- Tyrosyl-DNA phosphodiesterase 1
- Imidazole glycerol phosphate synthase hisHF, chloroplastic
- Histidinol-phosphate aminotransferase 2, chloroplastic
- Histidinol-phosphate aminotransferase 1, chloroplastic
- Endonuclease III homolog 1, chloroplastic
Sequence:
MDDFNLRSENPNSSSTTSSSSSSFHRHKSETGNTKRSRSTSTLSTDPQSVAARDRRHRISDRFKILQSMVPGGAKMDTVSMLDEAISYVKFLKAQIWYHQNMLLFINDHETTSSCTYSPGAGEFGPKLFGYDDDYAPIMDTYSQGVPLTVADSKYTPWFGSVDDEQEHVTYFKYRRATRHALRGHCNCIIGETEEFADQREKMEVQIEESGKNQTSPESIEADKAKQIVVLLIGPPGSGKSTFCDTAMRSSHRPWSRICQDIVNNGKAGTKAQCLKMATDSLREGKSVFIDRCNLDREQRSEFIKLGGPEFEVHAVVLELPAQVCISRSVKRTGHEGNLQGGRAAAVVNKMLQSKELPKVNEGFSRIMFCYSDADVDNAVNMYNKLGPMDTLPSGCFGEKKLDTKSQPGIMKFFKKVSALPASSSNEATNTTRKADEMTANVRVSPVKLGSADIVPTLAFPSISTADFQFDLEKASDIIVEKAEEFLSKLGTARLVLVDLSRGSKILSLVKAKASQKNIDSAKFFTFVGDITKLRSEGGLHCNVIANATNWRLKPGGGGVNAAIFKAAGPDLETATRVRANTLLPGKAVVVPLPSTCPLHNAEGITHVIHVLGPNMNPNRPDNLNNDYTKGCKTLREAYTSLFEGFLSVVQDQSKLPKRSSQTAVSDSGEDIKEDSERNKKYKGSQDKAVTNNLESESLEDTRGSGKKMSKGWNTWALALHSIAMHPERHENVVLEYLDNIVVINDQYPKARKHVLVLARQESLDGLEDVRKENLQLLQEMHNVGLKWVDRFQNEDASLIFRLGYHSVPSMRQLHLHVISQDFNSDSLKNKKHWNSFTTSFFRDSVDVLEEVNSQGKANVASEDLLKGELRCNRCRSAHPNIPKLKSHVRSCHSQFPDHLLQNNRLVARAET