Protein: E1A-binding protein p400 (EC 3.6.4.-) (Domino homolog) (mDomino) (p400 kDa SWI2/SNF2-related protein) (Q8CHI8)
Organism: Mus musculus (Mouse)
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Regulates transcriptional activity of ZNF42.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549}.
Interaction partners:
- Histone acetyltransferase KAT5
- DNA methyltransferase 1-associated protein 1
- RuvB-like 2
- Transformation/transcription domain-associated protein
- RuvB-like 1
- Bromodomain-containing protein 8
- YEATS domain-containing protein 4
- Actin-like protein 6A
- Vacuolar protein sorting-associated protein 72 homolog
- MRG/MORF4L-binding protein
Sequence:
MHHGSGPQNVQHQLQRSRSFTGSEEEQPAHPNLPPSPAAPFAPSASPSAPQSPGYQIQQLMSRSPVAGQNVNITLQNVGPVVGGNQQITLAPLPLPNPTSPGFQFGAQQRRFEHGSPSYIQVTSPMSQQVQTQSPTQPSPGPGQTLQNVRAGAPGPGLGICSNSPTGGFVDASVLVRQISLSPSSGGHFVFQEAPGLTQMAQGAQVQLQHSGAPITVRERRLSQPHAQSGGTIHHLGPQSPAAAGGTGLQPLASPNHITTASLPPQISSIIQGQLIQQQQQVLQGQPMNRSLGFERTPGVLLPGVGGPSAFGMTSPPPPTSPSRTTMPPGLSSVPLTSMGSSGMKKVPKKLEEIPPASQEMAQMRKQCLDYHYKEMEALKEVFKEYLIELFFLQHLQGNMMDFLAFKKKHYAPLQAYLRQNDLDIEEEEEEEEEEEGKSEVINDEVKVVTGKDGQTGTPVAIATQLPPNVSAAFSSQQQPFQHQSLTGSLVVGPGSATEADPFKRQQVMPPTEQSKRPRLEVGHPGVVFQHPGVNAGVPLQQLMPTVQGGMPPTPQATQLTGQKQSQQQYDPSTGPPVQNAASLHTPPPQLPARLPPASVPATALPSTLQFSQQSQMVEASTQLQIPVKTQQLNAPIPAPLPSQLPAPSSQPAQPALHVPMPGKAQMQTSQLSSQTQTVASTRPPLDSAQPCQRSLPTSSSSSSLVPVSGSGPGPSPARSSPVNRPSSATNKALSPITSRSPGVAVSAPPKPQSPAQNAASSQDGSQDKLAEQITLENQIHQRIADLRKEGLWSLRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKLAAAKKLVRTVARHHEEKKLREERGKKEEQSRLRRIAATTAREIEYFWSNIEQVVEIKLQVELEEKRKKALNLQKVSRRGKESRLKGFDTSPEHSLDLGISGRKRKASTSLTDDEVEDEEETIEEEEAHEGLVDHHTELTNLAKEAELPLIDLMKLYEGAFLPNFQWPQPEPDHEESSGEEDVEDCPSDRESRRDSVLIDSLFIMDQFKAAERMSIGKSNTKDITEVTAVAEAILPKGSARVTTAVKFSAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVVMRSCNILKWELELKRWCPGLKTLSYVGSHRELKAKRQEWTEPNNFHICITSYKQFFRGYTAFSRVHWKCLVVDEMQRVKGMTERHWEAIFKLQSQQRLLLIDVPLHNTFLELWTMVHFLIPGISRPYLSFPLKAPNEENQDYYHKMVIRLHRVTQPFILRRTKRDVEKQLTRKYEHVLKCRLSSRQKALYEDVILQPRTQEALKSGHFVSVLSVLTRLQRICNHPGLVEPRVPGSSFAAGSLQYKSASLILRVLEREFWKETDLSIFDLIGLENKITRHEAELLCKKKVTRKLMEEVFASPPPSARPAAVKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRMANTNTSTATPQGQVRGRPPIATFSANPDTKGGEVVKIAQLASIAGPQSRVAQPETPVTLQFQGNKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHSTLGSKPPTSGPSPAPLTPQVGVPGRVAVSAMAVGEPGLASKPASPAAGPTQEEKSRLLKERLDQIHFINERRCSQAPVYGRDLLRICSLPGRRKRPLCWSLDSNFGKGPKGVNYDMSLSKSEGDLILTLSQESLQDVLGRVACVIPPVVATPPSLWVARPPSLYSSRLRALRQCLREHTGPYHRQLQQLTALRSLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMVLMLDILEMFLNFHYLTYVRIDENANSEQRQELMRSFNRDRRIFCALLSTHSRATGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYSPMDDTGFPVKAEEFVVLSQEPSVSETIAPKIARPFIEALKSIECLEEDAQRSTEEAVPGSSSVAVSSDSDGSRYDEEPSQLEELADFMEQLTPIEKYALNYLELFHTTTEQEKERISEDLVMASMKDWETRNARALQEREARLQLEQEEAELLTYTREDAYTMEYVYEDADGQTEVMPLWTPPTPPQDDNDIYIDSVMCLMYETTPIPEAKLPPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGMLKIRREGKEQKKNLLLKQQTPFAKPLPTYVKSSGEPAQDSPDWLIGEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQLYTSHFELMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPPVTQPPPQQQQQQQQQQQQQQQQQQPPPPPQQPPPPVPQPQAASSQTPAGQPAVQPQPQPQVQTQPQPVQPQSKGQPTMTTVGSAAVLAGTIKTSVTGTSIPTGTVSGNVIVNTIAGVPAATFQSINKRLASPVAPGTLTTSGGSAPAQVVHTQQRAVGSPATATTDLVSMTTTQGVRAVTSVTASAVVTTNLTPVQTPTRSLVTQVSQATGVQLPGKTITPAAHFQLLRQQQQQQQQQQQQQQTSQVQVPQLQSQAQSPAQIKAVSKLGPEHIIKMQKQKMQLPPQPPPPQAQPGPPQQPAQVQVQTPQPPQQQQSPQLTTVTAPRPGALLTGTTVTNLQVARLTRVPTSQLQAQGQMQTQTPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKTAGQTVVAQPVNVQQLLKYKQQTAVQQQKAIQPQVAQGQAAVQQKLTTQQITTQGPQQKVAYAAQPALKTQFLTTPISQAQKLAGTQQVQTQIQVAKLPQVVQQQTPVASIQQVASASQQASPQTVTLTQATAAGQQVQMIPTVTATAQLVQQKLIQQQVVTTASASLQTPGGPSPAQLPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ