wanglab/gogpt-training-data huggingface dataset:
Protein: Small hydrophobic protein (Small protein 1A) (P0DOE5)
Organism: Human respiratory syncytial virus A (strain A2)
Function: Viroporin that forms a homopentameric ion channel displaying low ion selectivity. May play a role in virus morphogenesis and pathogenicity at various stages of the viral life cycle. Accumulates at the membrane of the Golgi apparatus in infected cells and may facilitate virus release by modifying the secretory pathway. May enhance host membrane permeability and disrupt cellular ion homeostasis, which can be sensed as damage-associated molecular patterns/danger signals, triggering NLRP3 inflammasome activation and inflammatory immune response. Also inhibits host TNFA-mediated signaling pathway and may delay apoptosis, allowing time for the virus to replicate.
Subcellular location: Virion membrane {ECO:0000305|PubMed:2649692}; Single-pass type II membrane protein {ECO:0000305}. Host cell membrane {ECO:0000269|PubMed:2649692}; Single-pass type II membrane protein {ECO:0000305}. Host Golgi apparatus membrane {ECO:0000269|PubMed:15105532, ECO:0000269|PubMed:23229815}; Single-pass type II membrane protein. Host endoplasmic reticulum membrane {ECO:0000269|PubMed:15105532, ECO:0000269|PubMed:25854864}; Single-pass type II membrane protein. Note=Present in very small amount in the virion. Detected in lipid rafts of host Golgi apparatus membrane. {ECO:0000269|PubMed:15105532}.
Interaction partners:
Sequence:
MENTSITIEFSSKFWPYFTLIHMITTIISLLIIISIMIAILNKLCEYNVFHNKTFELPRARVNT
Protein: LD22095p (Q8MRI7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDYVYCGTDPIGASEDILSVYDAGSAPGNGHFSPSFNGFNIGTTDPEYVELVPVLADGGEHFGVSSVAFDDYEELLWMGNQGGHVTSYYTNSMQKYTSFQVHATDIVRDISTLDSGVLALTQTSLRHQIRRGLPKFTFKSNNMKEMVSMLQLSPHRLVMAGLQDELIDFDLRTLKETRIEHVGAGGCTVLRKNSRYLFAGDQLGTVTLRDLNSLSVQHTIKTHTNILSDFSVQGNLLISCGYSGRQNNLAIDRFLMVYDLRMLRLIAPIQVMIDPQMLKFLPSLTSQLAVVSSYGQVQLVDTVELSEPRVSMYQINTNGSQCLSFDISSSSQAMAFGDQSGHINMIAAVQTPQPQFNLYSRSTEFADVVPQLPMVSITDTNFPLSSVMLPHLTTGTQWFSDWPEELLRYRYHRPKTIDPEVLSNMKMQGPIGYSPNPRTARRNQIPYVIEQGGVCSPNGNGTAAATKAENGVKIIPRRYRKVELKYTKLGTQDFDFDQHNQTCFAGLEATLPNSYCNAMLQILYFTDALRVKLLEHSCIKEFCLSCELGFLFNMLDKSTASSPCQASNFLRSFRTVPEASALGLILTDRSSNVNLISLIQNWNRFILHQMHYEIFDSSKNASTYSGSVQTSTNAENAGSSETSGSSDLYDSISGGQVN
Protein: Endonuclease III homolog (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase) (Q09907)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Also involved in the repair of 7-methylguanine lesions, although it cannot directly repair alkylated DNA bases. Probably does so via excision of methylformamidopyrimidine (mFapy) lesions, a spontaneous processing product of 7-methylguanine.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:16076563, ECO:0000269|PubMed:16823372}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03183}.
Interaction partners:
- DNA-
- Apurinic-apyrimidinic endonuclease 1
- Flap endonuclease 1
- DNA-3-methyladenine glycosylase 1
- Adenine DNA glycosylase
- Alkylbase DNA glycosidase-like protein mag2
- Uracil-DNA glycosylase
- DNA repair protein rad16
- Probable tyrosyl-DNA phosphodiesterase
- Bifunctional polynucleotide phosphatase/kinase
Sequence:
MSKDYGTPPENWREVYDEICKMKAKVVAPVDVQGCHTLGERNDPKKFRFQTLVALMLSSQTKDIVLGPTMRNLKEKLAGGLCLEDIQNIDEVSLNKLIEKVGFHNRKTIYLKQMARILSEKFQGDIPDTVEDLMTLPGVGPKMGYLCMSIAWNKTVGIGVDVHVHRICNLLHWCNTKTEEQTRAALQSWLPKELWFELNHTLVGFGQTICLPRGRRCDMCTLSSKGLCPSAFKEKSGITITKRKVKTIKRVKKRPASESPPLSPLSLPTDDLYYQSIEDKSLIKLEDLDPVDSISHMNEPLKKEPAADIDVDQKPPVAFHSTTKETRSLRRSKRVAKKSSQYFSQQSLQDIEDLV
Protein: Flavonol 3-O-glucosyltransferase F3GT2 (EC 2.4.1.91) (Flavonoid 3-O-glycosyltransferase 2) (A0A2R6P624)
Organism: Actinidia chinensis var. chinensis (Chinese soft-hair kiwi)
Function: Catalyzes the glucosylation of quercetin. Preferentially uses UDP-glucose as sugar donor, but is also able to use UDP-gal and UDP-xyl. Is probably not required for the accumulation of anthocyanin in red-fleshed kiwifruit varieties.
Interaction partners:
- Anthocyanin synthase
- Leucoanthocyanidin dioxygenase
- Dihydroflavonol 4-reductase
- Dihydroflavonol 4-reductase
- flavonoid 3',5'-hydroxylase
- Flavonoid 3'-monooxygenase
- Flavonoid 3'-monooxygenase
- Anthocyanidin reductase
Sequence:
MSDHSKALHVAVLAFPFGSHAAPLLALVCRLATSNPTVRFSFLSTAQSNTHTFPSTRTNEFDNVRPYNVWDGVPEGHQISGNPHVGTGFFLKALPHNFKAGMAKAEEESGATINCLLTDAFFWFAGDLAEEMGVPWVPYWTAGACSLSAHVNTDVIRITLGSTRTTQNTNQTLNFIPGLSAVHMNDLPGGVLHGDLESPFAQMLHKMGLNLPRATAVVLNSFEELEPAITTDLKLRLQKVLHVGPPSLSSSPTSSLDESGCLLWLDKHEAASVAYISFGTIITPPPNELLALAEALRASKIPFLWSLRDHSRPIFPEGFLENVLAFGKVVSWAPQSQVLAHPSIGVFVTHCGWNSILESITGGVPMICRPFFGDQTLNSRMVQDAWRIGVRLDGGVFTKSSMMSAVELIFSREEGKKLRENIILLKQKATDAVGASGSSTENFNVLLEVIKTCKHPKS
Protein: Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SUMO-1 protease 1) (SuPr-1) (SUMO-1/Smt3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) (Q91ZX6)
Organism: Mus musculus (Mouse)
Function: Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB. Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection.
Subcellular location: [Isoform 1]: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q9HC62}. Nucleus membrane {ECO:0000250|UniProtKB:Q9HC62}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9HC62}; Nucleoplasmic side {ECO:0000250|UniProtKB:Q9HC62}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9HC62}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11489887}. Cytoplasmic vesicle {ECO:0000269|PubMed:11489887}. Note=Found in the cytoplasm and in cytoplasmic vesicles, together with axin. {ECO:0000269|PubMed:11489887}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, PML body {ECO:0000269|PubMed:12419228}.
Interaction partners:
- Nuclear pore complex protein Nup153
- Segment polarity protein dishevelled homolog DVL-1
- Segment polarity protein dishevelled homolog DVL-2
- Segment polarity protein dishevelled homolog DVL-3
- Small ubiquitin-related modifier 1
- Small ubiquitin-related modifier 3
- Small ubiquitin-related modifier 2
- Ran GTPase-activating protein 1
Sequence:
MYRWLAKVLGTILRLCERPAPGARALLKRRRSSSTLFSTAVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVSSACNGTRNVAPSGEVFSNSSSCELMSSGSCSSMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLKSEGYNRRPSGRRHSKSNPESSLTWKPQEQGVTEMISEEGGKGVRRPHCTVEEGVQKDEREKYRKLLERLKEGAHGSTFPPTVSHHSSQRIQMDTLKTKGWVEEQNHGVRTTHFVPKQYRVVETRGPLCSMRSEKRYSKGKADTEKVVGLRFEKEGTRGHQMEPDLSEEVSARLRLGSGSNGLLRRKISVLEIKEKNFPSKEKDRRTEDLFEFTEDMEKEISNALGHGPPDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERSKKQGYPALHAFSTFFYPKLKSGGYQAVKRWTKGVNLFEQELVLVPIHRKVHWSLVVMDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNTDLNLLEWTHYSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
Protein: WD40 repeat-containing protein (Q54QH0)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Nuclear pore protein
- Uncharacterized protein
- mRNA export factor GLE1
- Uncharacterized protein
- Nuclear pore complex protein Nup98-Nup96
- Spore coat protein SP65
- RRM domain-containing protein
- RNA helicase
- Nuclear pore complex protein nup85
- Nuclear pore complex protein nup54
Sequence:
MFSTSTTTNPNNDIELSSPPSDGVSCLKFSPKANNFIVAGSWDQKVRCWEINPSTKSSMPKAIISHDAAILCTDWSGDGTKVFTGGVDGKGKCWNLATNQMVQVAQHTAPIKECFWIEESNVLVTASWDKTLKYWDTRQQTGTPVLSLELTERIYAMDMLYPLLAVATADKKIYIYDLKNPQSPYKTVDSLLKFQTRCISCFPDKSGFALGSIEGRVAIQSLDDSKQENSFTFKCHRENDTVAYAVNNISFALPYGTFATAGSDGGFSFWDKESKFRLKQFSKLPQSISTATFNLDASLYAYASSYDWSKGSQYFDPNQPNSIFVRVVGDEAKKGNRQTKKR
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9SQR8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g49990
- Serine/threonine-protein kinase MPS1
- Expressed protein
- Protein AE7-like 2
- Protein AE7-like 1
- Protein WEAK CHLOROPLAST MOVEMENT UNDER BLUE LIGHT 1
- Bystin
- Serine/threonine-protein kinase RIO2
Sequence:
MPELRSGARRSRRLDEQPNPPLVEQAENIVLPPQTATRRRGGGRGRGNAALAKGAAPPRPTAAGRGRGIRLTDLEPEPCEVRPAAGAIGATEPALNRVEGVADKDIAAEGGSAEKVVGMEEDSSMGPVPERVQVGNSPVYKTERKLGKGGFGQVYVGRRVSGGSDRIGADAIEVALKLEHRNSKGCNFGPPYEWQVYNTLNSCYGIPAVHHKGRQGDFYILVMDMLGPSLWDVWNSLAQSMSPNMVACIAVEAISILEKLHMKGFVHGDVKPENFLLGQPGTADEKKLYLIDLGLASRWKDSHSGQHVEYDQRPDVFRGTIRYASCHAHLGRTGSRRDDLESLAYTLIFLMRGRLPWQGYQGDNKSFLVCKKKMSTSPELMCCFCPPPFKLFLEAVTNMKFDEEPNYAKLISIFDTLIEPCAISRPIRIDGALKVGQKRGRLLINLEEDEQPRKKIRIGSPATQWISVYNARRPMKQRYHYNVADLRLAQHVEKGNEDGLFISCVASSANLWAIIMDAGTGFSSQVYELSSVFLHKDWIMEQWEKNYYISSIAGANNGSSLVVMAKGTPYTQQSYKVSDSFPFKWINKKWKEGFHVTSMTTAGSRWGVVMSRNSGYSEQVVELDFLYPSEGIHRRWESGYRITSMAATADQAALILSIPKRKITDETQETLRTSAFPSTHVKEKWAKNLYIASICYGRTVC
Protein: Interferon (Q8AY12)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Interferon regulatory factor 3
- Interferon gamma 1.
- Cytokine receptor family member b2
- ISG15 ubiquitin-like modifier
- Interferon gamma receptor 1-like.
- Interferon phi 3.
- Transcription factor p65
- Signal transducer and activator of transcription.
- Interferon phi 2
- Nuclear factor NF-kappa-B p105 subunit isoform X1
Sequence:
MRTQMWTYIFVIYVILQSQSSASTCEWLGRYRIITTESLNLLKNMGGKYADLETPFPSRLYTLMDKSKVEDQVKFLVLTLDHIIHLMDAREHMNSVNWDQNTVEDFLNILHRKSSDLKECVARYAKPAHKESYEIRIKRHFRTLKKILKKKQYSAEAWEQIRRVVKSHLQRMDIIASNARVNPRV
Protein: Testis-expressed protein 11 (Protein ZIP4 homolog) (ZIP4H) (Q14AT2)
Organism: Mus musculus (Mouse)
Function: Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.
Subcellular location: Chromosome {ECO:0000269|PubMed:18316482, ECO:0000269|PubMed:18369460, ECO:0000269|PubMed:30272023, ECO:0000269|PubMed:30746471}. Note=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes.
Interaction partners:
- Synaptonemal complex protein 2
- MutS protein homolog 4
- Protein shortage in chiasmata 1 ortholog
- Probable E3 SUMO-protein ligase RNF212
- Testis-expressed protein 15
- Meiotic recombination protein DMC1/LIM15 homolog
- HORMA domain-containing protein 1
- Probable ATP-dependent DNA helicase HFM1
- Meiotic recombination protein SPO11
- HORMA domain-containing protein 2
Sequence:
MDRITDFYFLDFRESVKTLIITGNSWRLQEMIDRFFTNISNFNRESLTEIQNIQIEEIAVNLWNWAVTKRVELSVRKNQAAKLCYIACKLVYMHGISVSSEEAIQRQILMNIKTGKEWLYTGNAQIADEFFQAAMTDLERLYVRLMQSCYTEANVCVYKMIVEKGIFHVLSYQAESAVAQGDFKKASMCVLRCKDMLMRLPNMTKYLHVLCYNLGIEASKRNKYKESSFWLGQSYEIGKMDRRSVEPQMLAKTLRLLATIYLNCGGEAYYTKAFIAILIANKEHLHPAGLFLKMRILMKGNSCNEELLEAAKEILYLAMPLEFYLSIIQFLIDNKRESVGFRFLRIISDNFKSPEDRKRILLFYIDTLLQKDQDMIAEEKIKDVLKGYQTRSRLSRDLVNWLHNILWGKASRSVKVQKYADALHWYSYSLKLYEYDKADLDLIKLKRNMVSCYLSLKQLDKAKEAIAEVEQKDPTHVFTRYYIFKIAIMEGDAFRALQVVSALKKSLMDGESEDRGLIEAGVSTLTILSLSIDFALENGQQFVAERALEYLCQLSKDPKEVLGGLKCLMRIILPQAFHMPESEYKKKEMGRLWNYLNTALLKFSEYFNEAPSTLDYMVNDANWFRKIAWNLAVQSEKDLEAMKNFFMVSYKLSLFCPLDQGLLIAQKTCLLVAAAVDLDRGRKAPTICEQNMLLRTALEQIKKCKKVWNLLKKTGDFSGDDCGVLLLLYEFEVKTKTNDPSLSRFVDSVWKMPDLECRTLETMALLAMDKPAYYPTIAHKAMKKLLLMYRKQEPVDVLKYSVCMHNLIKLLVADEVWNISLYPLKEVQSHFKNTLSIIRQNEGYPEEEIVWLMIKSWNIGILMSSKNKYISAERWAAMALDFLGHLSTLKTSYEAKVNLLYANLMEILDKKTDLRSTEMTEQLRALIVPPEDQGSVSSTNVAAQNHL
Protein: Sorting nexin-3 (O94291)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Prevacuolar compartment membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Vacuolar protein sorting-associated protein 26
- Vacuolar protein sorting-associated protein 35
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein sorting-associated protein 17
- Vacuolar protein sorting/targeting protein 10
- Vacuolar protein sorting-associated protein vps5
- Pre-mRNA-splicing factor sap114
Sequence:
MDKLSRPEIRQQTTQQMYDVPENILEIDVINPQTHGIGRNMFTTYEIVCRTNMPYFRLHNSSVRRRYSEFEKFHDMLERESGRVSIPPLPGKIFTQRFRDDVIEERRQGLENFLRLVAGHPLIQTHSRVLSSFLQSPEFKPTP
Protein: BTB/POZ domain-containing protein KCTD11 (KCASH1 protein) (Potassium channel tetramerization domain-containing protein 11) (RING-type E3 ubiquitin transferase subunit KCTD11) (Q8K485)
Organism: Mus musculus (Mouse)
Function: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
Interaction partners:
- Cullin-3
- Potassium channel tetramerisation domain containing 17
Sequence:
MLGAMFRADTLMPANLNPQGDGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLKAEADFYQIRPLLDALRELEASRGTPASTAALLHADVDVSPRQVHFSARRGPHHYELSSVQVDTFRANLFCTDPECLAAMRNRFGVAIGDRAEGGPHFRLEWASRPQELPEVEYQRLGLQPLWTGGPEDRREVANTPTFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH
Protein: Uncharacterized protein (Q389Y9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVLIECKRLPKDEYSKDYDVFLVSMPGSTNIGEATDALQKMRNTRVRIKWMCAAAKQLAKDFCSDEQKHHLLGAVEDAERYMAIERAENRQLCSQEDLDAHIAAFKGSAMILFPAECSGTDAVKRLALVLDDENTTDLERSKAHRLLSIIDDGAATEDILQGPAVMWWSGKPLDRNADFTKYVGKNEKTKITMKLAAKDAPPPPREPAVDAKTQSEMMAFYFKKQEEMKKLIEDEDLTYGNSAWADPRGLRSQLHGFDGVKYKPG
Protein: T-complex protein 1 subunit epsilon (CCT-epsilon) (F1MWD3)
Organism: Bos taurus (Bovine)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit zeta-2
- Chaperonin containing TCP1 subunit 8 like 2
- T-complex protein 1 subunit theta
Sequence:
MASVGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMKTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARIAIEHLDKISDSVLVDMKNTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMQRRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKQVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDFKALQKYEKEKFEEMIRQIKETGANLAVCQWGFDDEANHLLLQNDLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVKEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALAENSGMNPIQTMTEVRARQVKEVNPALGIDCLHKGTNDMKHQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
Protein: GTP-binding protein rhoA (J9VT08)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Interaction partners:
Sequence:
MSGEIRRKLVIVGDGACGKTCLLIVFSKGMFPEVYVPTVFENYVADVEVDGKKVELALWDTAGQEDYDRLRPLSYPDSHVILICFAIDSPDSLDNVQEKWISEVLHFCQGLPIVLVACKKDLRDDGKTIQDLARMNQRPVSRAEGMAVAQKIGAQGYVECSAKTGEGVREVFQTATRHALQSKKSKSGRGKKGCVVL
Protein: G-protein coupled receptor (Q2PBC2)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MASSVCNNSFGAVQTTFLAPMYGVAFVVSVLGNSLAIWLLGPGSSKNRHAGIIFSLNLAVSDLFYSLSLPLLVAYYTMNKNWVFGLAMCKVERFVFNCNLYGSIFFITCISANRYLGIVFPFYTRGRVESKHAKWVSLGVWVLVAAISAPVFLFSKLQVENNKTECLGTAVNSELPSYFPYSLFLAGFGCALPFLITFLSYIGIAKAVWKSHGLEPREKRKVVTLVCVVVLLYAISFVPYHILRNLNLKNRIATSDCKWSLKIHSAFQVAKALVSLNPCIHPLLYTAVIDNVRAKLGCYQESQDVKSQGESRL
Protein: Zinc finger protein 398 (Zinc finger DNA-binding protein p52/p71) (Q8TD17)
Organism: Homo sapiens (Human)
Function: Functions as a transcriptional activator.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein 282
- Zinc finger protein 212
- Probable ATP-dependent RNA helicase DDX17
- Zinc finger protein 783
- Zinc finger protein 746
- Engulfment and cell motility protein 1
Sequence:
MAEAAPAPTSEWDSECLTSLQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIHSRRLLHLEGRTGTAEKKLASCEKTVTELGNQLEGKWAVLGTLLQEYGLLQRRLENLENLLRNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLISMDYAINQPDVLSQIQPEGEHNTEDQAGPEESEIPTDPSEEPGISTSDILSWIKQEEEPQVGAPPESKESDVYKSTYADEELVIKAEGLARSSLCPEVPVPFSSPPAAAKDAFSDVAFKSQQSTSMTPFGRPATDLPEASEGQVTFTQLGSYPLPPPVGEQVFSCHHCGKNLSQDMLLTHQCSHATEHPLPCAQCPKHFTPQADLSSTSQDHASETPPTCPHCARTFTHPSRLTYHLRVHNSTERPFPCPDCPKRFADQARLTSHRRAHASERPFRCAQCGRSFSLKISLLLHQRGHAQERPFSCPQCGIDFNGHSALIRHQMIHTGERPYPCTDCSKSFMRKEHLLNHRRLHTGERPFSCPHCGKSFIRKHHLMKHQRIHTGERPYPCSYCGRSFRYKQTLKDHLRSGHNGGCGGDSDPSGQPPNPPGPLITGLETSGLGVNTEGLETNQWYGEGSGGGVL
Protein: Histamine H1 receptor (H1-R) (H1R) (HH1R) (P35367)
Organism: Homo sapiens (Human)
Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21697825}; Multi-pass membrane protein {ECO:0000269|PubMed:21697825}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Transient receptor potential cation channel subfamily V member 1
- Guanine nucleotide-binding protein G
- Histidine decarboxylase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-15
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
Protein: Ribosomal RNA small subunit methyltransferase, mitochondrial (EC 2.1.1.-) (18S mitochondrial rRNA (adenine(1914)-N(6)/adenine(1915)-N(6))-dimethyltransferase) (Adenosine dimethyl transferase 1B) (Dimethyladenosine transferase 1B) (Q9FK02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: N6-adenine methyltransferase which modifies the AA dinucleotide at the plant mitochondrial 18S rRNA nucleotides A1914 and A1915. Not active as mitochondrial transcription factor.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19929881}.
Interaction partners:
- Bystin
- DNA-directed RNA polymerase 3, chloroplastic
- Periodic tryptophan protein 2
- Putative U3 small nucleolar ribonucleoprotein
- At3g49990
- Transducin family protein / WD-40 repeat family protein
- Probable cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG6
- At1g42440/F7F22_7
- Putative WD-repeat membrane protein
- Protein NUCLEOLAR COMPLEX ASSOCIATED 4
Sequence:
MILRLKDQTLIKINSTRSYLSSLVFRRDSHSQARTKPDHDRRRRGYERDVRIEEKKEHDGLFLCKSKGQHLLTNTRILDSIVRSSDIRPTDTVLEIGPGTGNLTMKLLEAAQNVVAVELDKRMVEILRKRVSDHGFADKLTIIQKDVLKTDFPHFDLVVANIPYNISSPLVAKLVYGSNTFRSATLLLQKEFSRRLLANPGDSDFNRLAVNVKLVADVKFVMDVSKREFVPPPKVDSSVIRITPKEIIPDVNVQEWLAFTRTCFGKKNKTLGSMFRQKKKVMELQSLSAGRHGSNVEVMNQTGGDSDSDVEEDGKDDLLCLDTDASMFKERVIEILRTNGFEEKRPSKLSHRELLHLLSLFNQAGIFFHDITSLQMDLHE
Protein: Transcriptional activator protein rec16 (Zinc finger protein rep1) (P40379)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transcriptional activator that controls the onset of premeiotic DNA synthesis by regulating res2 and some other factor(s) in a mei2 independent cascade.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcriptional activator protein rep2
- Start control protein cdc10
- Carboxypeptidase sxa2
- Cell division cycle-related protein res1/sct1
Sequence:
MDSDRCLTDEISLNTLSSTFASDNNLRRKENFLKSRYPSKFDLNVSMLTKSDDVGKTPFSIFDSPSNPGFSRSHQMCSDKNKSPFLFDKIRDEPVSVDPVKLIINNRNKRKINRQKSRLQGLYRSDANGLQPLNSENVKMKKSTALSLTSSPLNSWKTDFKTPPKANVVCISLVIEGDGCASLLYEDLNQISNSCPEVAPNRQNALFSDETLTTMFYSGVTEDEGSCNNLLQSSFGDDLDLGMQRSATWAPGYNYPSKFDSIPFASASPKIKAAFPFDPNVYALNTNDGPVTSTDNNCDQLNTRMQAWNNGFNYSNLNGDIQYPAVTPKFFQQEGRALNVSDCNFGNEEIAYGGIPMRVCHSDSTLCDARIAAKQALKGKRQYDTSTSKAELSTPPSKRRHIDDADLVFHSSPLLSRSRFICCYCTKPFLSISKLQEHESSCSHVERLFGFAPNRLYDDGDGFLGSSFCSDW
Protein: Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family (NDR1/HIN1-like protein) (Q9C568)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Hypersensitive-induced response protein 1
- Monocopper oxidase-like protein SKU5
- Calmodulin-5
- Purine-uracil permease NCS1
Sequence:
MTGRYCDQHNGYEERRMRMMMRRIAWACLGLIVAVAFVVFLVWAILHPHGPRFVLQDVTINDFNVSQPNFLSSNLQVTVSSRNPNDKIGIFYDRLDIYVTYRNQEVTLARLLPSTYQGHLEVTVWSPFLIGSAVPVAPYLSSALNEDLFAGLVLLNIKIDGWVRWKVGSWVSGSYRLHVNCPAFITVTGKLTGTGPAIKYQLVQRCAVDV
Protein: Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Q9VW73)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Late endosome membrane {ECO:0000256|ARBA:ARBA00004577}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004577}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004577}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004122}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004122}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004122}.
Interaction partners:
- Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
- Ragulator complex protein LAMTOR3 homolog
- Ragulator complex protein LAMTOR4 homolog
- Ragulator complex protein LAMTOR2 homolog
- GH16429p
- GH04846p
- Raptor, isoform B
- V-type proton ATPase subunit B
- Serine/threonine-protein kinase mTor
- Protein LST8 homolog
Sequence:
MEYVHSVWSYLASICNCWQCTEDPGAQPNEPNERTHLLVDPVNHSPALRRSNSDGLSTDYAHSLPKKDDQNALSRLVQNTAINMINVGAMDCHSLEHQEYADRIRLYSQRLHQQWNNGQHASIAPKGLLKDVPSHQFYLSKPTYPDDTAQMKLFTEKAHISVSHIQIDHKEAVVVPFRIP