wanglab/gogpt-training-data huggingface dataset:
Protein: Replication origin-binding protein (OriBP) (OBP) (P52377)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Function: Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins. In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication (By similarity).
Subcellular location: Host nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MTATPGAAADAVRVEGAGACSDGGEEARYASSASLARMLYGADLSERVRRRHPAVCVEHQSGRPVALPSPLAADARRVTVVRAPMGSGKTTALLRWLGEALGATDASVLVVSCRRSFTRTLHERLRDAALPAFATYFDARSYVMTGAAYRRLLVQVESLHRVDEELLGDYDILVLDEVMSTLAQLYSPTMGRLHRVDALLHRLLRRCPRIVAMDATVNAQLVDLLAALRGAGSVHVVICDYASAGFLQRRCTVARRLGARVLAARLKGDAEDGAEDGGASFFTRLRARLEAGHNVCVFSSTVLFSELAARFCLTFTPSVLVLNSTRPAEGDVSRWRDVRVLIYTTVITVGLSFDHSYFHAMFAYVKPMSHGPDMVSVYQSLGRIRSLVDNELCVYFDSSAARPEPVFTPMLLNHVVAEDGGWPATFSEVTNLLCCSFRAACAPAFRGARGLALFPRFKYKHLFERCTLASASDSLNILHALLENNRVGFQLEALRSAHRRGILPLSRGRARRRPAAAADLRALAAGIPSPVSAEGLAEHPAVAAFADKYLRAGGAPPAALEELLRALNGPAARARFVNLAVLGGCLHVPAAAESLEVFAGIYRHYASGEVPVLTEAGAVETAALAPGLRWKPTALFGLRRMARALGLLRRRGGGEADDVADAAHGLTEPAIVELVGPPGGHDYAQCLLEIARCNITPAGVMARGPVVAVAARLSGRGFAQGRGVGLGAAAHAVSVFKVIWEEVFGARLQKSTQTFPGHARVKNLRKHEIVALLDLAGIDRAGRDTHRELYRLLMSHKARFASPKYSLRLPKWGRLLGFAARGPEPGPDAPPEASLEAALARVPALHWPCAAGAVDFCAL
Protein: Cholinephosphotransferase 1 (mCHPT1) (EC 2.7.8.2) (Diabetic nephropathy-associated gene transcript 1) (Diacylglycerol cholinephosphotransferase 1) (Q8C025)
Organism: Mus musculus (Mouse)
Function: Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8WUD6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8WUD6}.
Interaction partners:
- Choline-phosphate cytidylyltransferase B
- Choline-phosphate cytidylyltransferase A
- Phosphatidylethanolamine N-methyltransferase
- Lysophosphatidylcholine acyltransferase 2
- Lysophosphatidylcholine acyltransferase 1
- Phosphatidylserine synthase 1
- Lysophospholipid acyltransferase 5
- Phosphatidate phosphatase LPIN1
- Phospholipase D2
- Phospholipase D1
Sequence:
MAAGAGARPAPRWVKALGEPLSAAQLRRLEEHRYTAVGESLFEPPLQLYWTWLLQWIPLWMAPNTITLIGLAINLVTTLVLIFYCPTVTEEAPYWTYLLCALGLFIYQSLDAIDGKQARRTNSCSPLGELFDHGCDSLSTVFMAIGASIAVRLGTHPDWLFFCSFVGMFMFYCAHWQTYVSGVLRFGRVDVTEIQVALVIVFMLSTFGGATMWDYTIPILEIKLKIVPVLGVVGGLIFSCSNYFHVILHGGVGKNGSTIAGTSVLSPGLHIGLIIILAIMIYKKSATNMFEKHPCLYTLMFGCVFAKVAQKLVIAHMTKSELYLQDTVFIGPGLLFLDQYFNNFIDEYVVLWIAMVISSFDMMIYFTSLCLQISRHLHLNIFKTSCQQAPEQVYKHID
Protein: Ubiquitin-conjugating enzyme E2 5 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 5) (Ubiquitin carrier protein 5) (Ubiquitin-conjugating enzyme E2-21 kDa 2) (Ubiquitin-protein ligase 5) (P42749)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 4
- Ubiquitin-conjugating enzyme E2 6
- Probable ubiquitin-conjugating enzyme E2 33
- Probable ubiquitin-conjugating enzyme E2 26
- Ubiquitin-activating enzyme E1 2
- Ubiquitin-conjugating enzyme E2 32
- Ubiquitin-activating enzyme E1 1
- Probable ubiquitin-conjugating enzyme E2 25
- NEDD8-activating enzyme E1 catalytic subunit
- Ubiquitin-conjugating enzyme E2 34
Sequence:
MSSPSKRREMDLMKLMMSDYKVEMINDGMQEFFVEFSGPKDSIYEGGVWKIRVELPDAYPYKSPSVGFITKIYHPNVDEMSGSVCLDVINQTWSPMFDLVNVFETFLPQLLLYPNPSDPLNGEAAALMMRDRPTYEQRVKEYCEKYAKPRADTEEMSSDDEMSEDEYASDGDDEDDVAIAGKLDP
Protein: Mitochondrial-processing peptidase subunit alpha-1 (Alpha-MPP) (Ddalpha-MPP) (Inactive zinc metalloprotease alpha-1) (Q86A84)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:18603769}.
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Mitochondrial-processing peptidase subunit beta
- Probable cytochrome b-c1 complex subunit 6
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit
- Cytochrome c oxidase subunit 5
- NADH dehydrogenase flavoprotein 2, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase iron-sulfur protein 4
Sequence:
MNIIFLKVPSIFKKLNVGNIKILNVNQNSPSIIVNSNNTKSIKNHNYSSFTNNNNNNNKNQVNLVQNKSILSSSSSYKGNNNNNNKLSYTTSSNNNNNNKIEEIVKSTTVSPFTPLNILHPKLVGEKLYSNDNEANNNQKEFKAEISTLPNGIRVVSKQTHEGVCAIGLYINAGTKYESPQDRGVFNLLEKMTFKETKNNSTSEIIKELEEISMNAMASSSREMINVSLEVLRKDLEFVLSILSDQIKSPTYSEEELREQIEVCIRNYEMITNSSSDQLMTEILMGVAFGDAGLGNLVIATPEQYQNITREKLFDALRKYYVGKNIVISVTGAEHSQVIELVDKYFGDIPFTQKDTPSEDSIDSTITYKGGTDACVAGLIHKNHLKSQLQFLIEKQQKLKQQQQQQQPQPQNSNIDDNDNEEELLNLEIEQTKISIEQLELQQVKESSWIIAFPHSGLSTVAENKDIINGLVLQSLLGGGSSYSTGGPGKGMQSRLNLNVVYSSHRVKNCHAFLFVFNKVSLFGISLTTQSGFLQDGIELVLQELLMLRSSMTQQELERAKRSQKSQILQNLEMRSVQCDDMARHILSFGSYKSPEQICKLIDSVTLDDIKKLISKLAQSNPSVVSIVANENEPILTAEQYNQIVKQNSSTLFK
Protein: Nuclear pore complex protein (A1YK60)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000256|RuleBase:RU365072}. Nucleus membrane {ECO:0000256|RuleBase:RU365072}.
Interaction partners:
Sequence:
MADSPFPRSSRSGLLRTTLNSSMAPQNLSHSLLILEKSNAEQNERSLMEDTGDDLDRGKSRMDVLFPQFFDVLQAQGNGQEAFEVIQSLTQVCRGVVEQLELEIDHGMGGEQGARQRESMLTWLRQEINTWRLLHALFYDRILLQTDRQADDEMQDGPTLGGSEKEVIQQLYALNATLREYQVVVDWLEACYDRGEQQNPLHAHDRMMAWENTLFQLENLQGAAFGKGHKIVTRLDPDAPVREKRPLHALDEEDNLRLSRAIFELIRAGRVDDGLKLCKHFGQTWRAAILEGWRLHEDPNFEQNVSVLHEKLPIEGNPRRDIWKRCAWLLADSKNYDEYSRATAGVFSGHLGSLKTLLHSNWHDLLWAHLKVQIDIRVESEIRGCCLKNYQPMPDDYWNGRMTMEQIFEELNVAKDASVRDFAQSQLGIIQRHLILDTCGELIQHMVRWVEKDTAQQSPHQLRFMAHIVLFLRQIGRVEQERQAEKIVAAYVEALIARGEPQLIAYYTASLSNPLQVQLYSRFLEQVEQKRPRELAVDAALQAGLDVEQITRVTVQNIRLAHQPLGEFGEPQSGEISAIDQRKISALEWLIHLPEQRGELLWQANAMIRTYLASSKVECMRQTFRMVPADIVQQLVSLYGSVDNIPPREECCLKEYLCYKAYLSGVDSFVEWNRLQQNRPKKPQTSHAASSQDNFTERMASERKEQAHRSEVVRWEHKVKEQAKQTIELLYNVLMFPDKGWLVDPFIAKLPENAVQLNWDHRLLQMEKLRSICIPEIALFLNEVMFKSGDFAGCVRLADEISSENRQLYKVYTKHKLAELLAKIADASLELLNSKLDPWGYPITT
Protein: Progesterone immunomodulatory binding factor 1 (A0A087WUI6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREVFFLFCHNCNHFRLF
Protein: Jasmonate ZIM domain-containing protein 1 (GmJAZ1) (HopZ1a-interacting protein 3) (C6TCZ5)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Repressor of jasmonate responses.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:24204266}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:24204266}. Cell membrane {ECO:0000269|PubMed:24204266}. Note=(Microbial infection) Interacts with Pseudomonas syringae HopZ1a at the plasma membrane and in the nucleus. {ECO:0000269|PubMed:24204266}.
Interaction partners:
- Protein TIFY
- Coronatine-insensitive 1
- Transcription factor MYB13
Sequence:
MSSFPNTVAEGRRSGKAPEKSTFSQTCSLLSQFLKEKRASADSTLGIGGKMEPKANTKALLGSLQNSDGALKLSASAMEFLPQLVENPCIKKSRSPGPESPQLTIFYAGKMLVFDAFPPEKATEVMEMATKLASNNSGTEESPPSLPVTTEKLAVSKMPQTNTSSETPKPGNQGVGSDMRYPRRASLLKFLEKRKERVNARGPYQMNNLKPEGSSSGGEPEDQCSKQFDLNF
Protein: GRB10 interacting GYF protein 2 (C9JHW1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGRSSSRGRGRPNFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEER
Protein: RH29451p (Q8IGG1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
IQLTKPNQIKMHFTASLLFIGLACAFSSAWAYPYPDPREIVNLQPEPLAYAPNFDVPLHRVRRQFQLNGGGGGSPKQGFDLSLNGRAPVWQSPNGRHSFDATGSYAQHLGGPYGNSRPQWGAGGVYTFRF
Protein: SPX domain-containing protein 1 (Protein SPX DOMAIN GENE 1) (AtSPX1) (Q8LBH4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a positive role in plant adaptation to phosphate starvation. Inhibits PHR1 DNA-binding activity in a Pi-dependent manner.
Subcellular location: Nucleus {ECO:0000269|PubMed:18315545, ECO:0000269|PubMed:25271326}.
Interaction partners:
- Protein PHOSPHATE STARVATION RESPONSE 1
- Protein PHR1-LIKE 1
- Inorganic phosphate transporter 1-4
- Phosphate transporter PHO1
- Myb family transcription factor PHL4
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase VIP2
- Probable ubiquitin-conjugating enzyme E2 24
- Inorganic phosphate transporter 1-1
- Glycerophosphodiester phosphodiesterase GDPD1, chloroplastic
- Monogalactosyldiacylglycerol synthase 3, chloroplastic
Sequence:
MKFGKSLSNQIEQTLPEWQDKFLSYKELKKRLKLIGSKTADRPVKRLRLDEFSVGISKEEINFIQLLEDELEKFNNFFVEKEEEYIIRLKEFRDRIAKAKDSMEKMIKIRKEIVDFHGEMVLLENYSALNYTGLVKILKKYDKRTGDLMRLPFIQKVLQQPFYTTDLLFKLVKESEAMLDQIFPANETESEIIQAELSEHKFMESLHMKSTIAALRVLKEIRSGSSTVSVFSLPPLQLNGLDETWKKIPLLEQEAK
Protein: Homeobox protein MSX-3 (P70354)
Organism: Mus musculus (Mouse)
Function: Acts as a potent transcriptional repressor of MSX1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11115394}.
Interaction partners:
- Homeobox protein MSX-1
- Homeobox protein MSX-2
Sequence:
MARATFDMNAAGLEARGGGHTEHGPLPFSVESLLEAERVPGSESGELGVERPLGASKPGAWPPPVAHSCPPRAPSPPPCTLRKHKTNRKPRTPFTTAQLLALERKFHQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKLAAKPLLPAAFALPFPLGTQLHSSAATFGGNAVPGILAGPVAAYGMYYLS
Protein: FI15207p1 (Q9VQ58)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Lysine-specific demethylase 5
- Paired amphipathic helix protein Sin3a
- PHD finger protein 12
- Histone deacetylase HDAC1
- FI07430p
- Inhibitor of growth protein
- BRMS1 transcriptional repressor
- Chromatin assembly factor 1 p55 subunit
- Sin3A-associated protein 130, isoform C
- Hat-trick, isoform D
Sequence:
MWPQTLEMSRDECRGMLRRLELESYSHVVSVFRAQGALSETKAKLLEELRQQFHINQERHRAEVRRAANDEQLCTIAENVCGPNTWQEWSREGRRLYPLLPRISPQTALSIVANDLAAKACEENAKLAAPAETAVHFGEALVEQASLMSLKYPRGARIQDTAMVIMAEPFKVPDLPNEVKKMTQKRKENDSGIDGKPNKKRHMQQPHPQQPHLQASQQQQQSQQLNPNSSNPGMEEADPVPPEKRMTARTLQQRYFYQQQMKHKQRLASKRNLANRLGSPSAQSGNPLGGRNMPSSGGDTSTAKRSAAPAKSGRRAQKQLQQQQKLQQHQQQKVLMQSQETVPNHMVVQPHVEYVLDEALKTLAASNPPTPTSTVAPPYTILNEPRPLVTLKPLKTIKPMIYGPQSGMPSAEIGSPTTPGSRGFANSPIVFKEKLQASPVQVATQGQGSPTKKFVAEERHADAMPSAATTPTPISTANLPLAPQIISVQKIPAPSMGGKLRAAVASPTSSTNSTLLPPGAKTTPKKFNILEGDAKPKTLPSSAVRLLPYTEPIGGPLSPLKDSRVTPLSSASTVNIIKNIPASSLNNTLITPLPSAGTTMPANLFRAKVTPSIKGASGAAGGATVIGAAGATGIGGAGAGPQILGNIKLTSSSGGAATIKQVPSSALRNIKICSPNGKLFLQPGKLPAGSIIHKFNNASSTAVSAAGGVVTTTTTTVSPTKQPAREQRISIQKILQPATGSASSGSSSPTTTTTTISGLTSSAKQPGLGNKPTTLTFATAGGGKNNLVFLPASAASGMRALTLATKPKSNVLVIGASTSPASAASSPNPSGGTKPKANQLITEDTPIDIINMPIIVADNGTAAELNQASVKNSPLVVFNATDWEMELDQAATKSASTTSKQALDDVIIEEDEDAEEEARESSEQPSTMDLNNSIIELHPEDDSAIEYVDMDLEQPVEIESTSNISPETATTTLKAAIVSTSPQQQQQQPQKKHPPLEHPLSAGAAAGTGSSTGAAVQSAIKLP
Protein: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) (P11017)
Organism: Bos taurus (Bovine)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P62879}. Cell membrane {ECO:0000250|UniProtKB:P62879}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L1
- Guanine nucleotide-binding protein G
- 5-hydroxytryptamine receptor 7
- Guanine nucleotide binding protein
- Guanine nucleotide-binding protein subunit alpha-11
- Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Protein: NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) (O09130)
Organism: Mus musculus (Mouse)
Function: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
Subcellular location: Nucleus. Cytoplasm. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.
Interaction partners:
- E3 SUMO-protein ligase RanBP2
- SUMO-conjugating enzyme UBC9
- SUMO-activating enzyme subunit 1
- SUMO-activating enzyme subunit 2
- Proliferating cell nuclear antigen
Sequence:
MAEPLRGRGPRSRGGRGARRARGARGRCPRARQSPARLIPDTVLVDLVSDSDEEVLEVADPVEVPVARLPAPAKPEQDSDSDSEGAAEGPAGAPRTLVRRRRRRLLDPGEAPVVPVYSGKVQSSLNLIPDNSSLLKLCPSEPEDEADLTNSGSSPSEDDALPSGSPWRKKLRKKCEKEEKKMEEFPDQDISPLPQPSSRNKSRKHTEALQKLREVNKRLQDLRSCLSPKQHQSPALQSTDDEVVLVEGPVLPQSSRLFTLKIRCRADLVRLPVRMSEPLQNVVDHMANHLGVSPNRILLLFGESELSPTATPSTLKLGVADIIDCVVLASSSEATETSQELRLRVQGKEKHQMLEISLSPDSPLKVLMSHYEEAMGLSGHKLSFFFDGTKLSGKELPADLGLESGDLIEVWG
Protein: Mitochondrial import inner membrane translocase subunit TIM14 (DnaJ homolog subfamily C member 19) (Q96DA6)
Organism: Homo sapiens (Human)
Function: Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:12592411}; Single-pass membrane protein {ECO:0000305|PubMed:12592411}; Matrix side {ECO:0000250|UniProtKB:Q9CQV7}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import inner membrane translocase subunit TIM44
- Stress-70 protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim17-A
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit Tim21
- Mitochondrial import inner membrane translocase subunit Tim17-B
- Methylglutaconyl-CoA hydratase, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim23
- Heat shock 70 kDa protein 4
Sequence:
MASTVVAVGLTIAAAGFAGRYVLQAMKHMEPQVKQVFQSLPKSAFSGGYYRGGFEPKMTKREAALILGVSPTANKGKIRDAHRRIMLLNHPDKGGSPYIAAKINEAKDLLEGQAKK
Protein: Noggin (Q62809)
Organism: Rattus norvegicus (Rat)
Function: Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (By similarity). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Bone morphogenetic protein 7
- Bone morphogenetic protein 2
- Bone morphogenetic protein 4
- Bone morphogenetic protein 6
- Growth/differentiation factor 5
- Bone morphogenetic protein 5
- Growth differentiation factor 7
- Growth/differentiation factor 6
- R-spondin-1
- Bone morphogenetic protein 8a
Sequence:
GGGGGPAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWARYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC
Protein: Axin-1 (Axis inhibition protein 1) (Q14DJ8)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQSPKMNVQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPYLRWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDSNGIVSRQTKPATKSFIKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGMSGYLPTLNEDEEWKCDQDADEDDGRDPLPPSRLTQKLLLETAAPRAPSSRRYNEGRELRYGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESIQVNGRVPLPHIPRTYRMPKEIRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGEMPSGPMASHKLPSVPAWHHFPPRYVDMGCSGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSGHVAKTAVLGGTASGHGKHVPKLGLKLDTAGLHHHRHVHHHVHHNSARPKEQMEAEVARRVQSSFSWGPETHGHAKPRSYSENAGTTLSAGDLAFGGKTSAPSKRNTKKAESGKNANAEVPSTTEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGLRKQQAHESSRPLSIERPGAVHPWVSAQLRNSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRANKLPSKQRTKSQRKAGGGSAPPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD
Protein: Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] (Q9BR39)
Organism: Homo sapiens (Human)
Function: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity).
Subcellular location: [Junctophilin-2]: Cell membrane {ECO:0000250|UniProtKB:Q9ET78}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9ET78}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ET78}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9ET78}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ET78}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9ET78}. Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands. {ECO:0000250|UniProtKB:Q9ET78}.; SUBCELLULAR LOCATION: [Junctophilin-2 N-terminal fragment]: Nucleus {ECO:0000269|PubMed:30409805}. Note=Accumulates in the nucleus of stressed hearts. {ECO:0000250|UniProtKB:Q9ET78}.
Interaction partners:
- Triadin
- Caveolin-3
- Ryanodine receptor 1
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Ryanodine receptor 2
- Synaptophysin-like protein 2
- Aspartyl/asparaginyl beta-hydroxylase
- Striated muscle preferentially expressed protein kinase
- Calsequestrin-1
Sequence:
MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPASPASDGPALPSPAIPRGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSDLSSGASDAASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQLKSNKVRQKVEHSVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLARELAPDFYQPGPEYQKRRLLQEILENSESLLEPPDRGAGAAGLPQPPRESPQLHERETPRPEGGSPSPAGTPPQPKRPRPGVSKDGLLSPGAWNGEPSGEGSRSVTPSEGAGRRSPARPATERMAIEALQAPPAPSREPEVALYQGYHSYAVRTTPPEPPPFEDQPEPEVSGSESAPSSPATAPLQAPTLRGPEPARETPAKLEPKPIIPKAEPRAKARKTEARGLTKAGAKKKARKEAALAAEAEVEVEEVPNTILICMVILLNIGLAILFVHLLT
Protein: Pentatricopeptide repeat-containing protein At4g30700 (Protein DYW9) (Q9SUH6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Phosphoglycerate mutase family protein
- ATP-dependent zinc metalloprotease FTSH 10, mitochondrial
Sequence:
MLLRTVSSATAETTAALISKNTYLDFFKRSTSISHLAQTHAQIILHGFRNDISLLTKLTQRLSDLGAIYYARDIFLSVQRPDVFLFNVLMRGFSVNESPHSSLSVFAHLRKSTDLKPNSSTYAFAISAASGFRDDRAGRVIHGQAVVDGCDSELLLGSNIVKMYFKFWRVEDARKVFDRMPEKDTILWNTMISGYRKNEMYVESIQVFRDLINESCTRLDTTTLLDILPAVAELQELRLGMQIHSLATKTGCYSHDYVLTGFISLYSKCGKIKMGSALFREFRKPDIVAYNAMIHGYTSNGETELSLSLFKELMLSGARLRSSTLVSLVPVSGHLMLIYAIHGYCLKSNFLSHASVSTALTTVYSKLNEIESARKLFDESPEKSLPSWNAMISGYTQNGLTEDAISLFREMQKSEFSPNPVTITCILSACAQLGALSLGKWVHDLVRSTDFESSIYVSTALIGMYAKCGSIAEARRLFDLMTKKNEVTWNTMISGYGLHGQGQEALNIFYEMLNSGITPTPVTFLCVLYACSHAGLVKEGDEIFNSMIHRYGFEPSVKHYACMVDILGRAGHLQRALQFIEAMSIEPGSSVWETLLGACRIHKDTNLARTVSEKLFELDPDNVGYHVLLSNIHSADRNYPQAATVRQTAKKRKLAKAPGYTLIEIGETPHVFTSGDQSHPQVKEIYEKLEKLEGKMREAGYQPETELALHDVEEEERELMVKVHSERLAIAFGLIATEPGTEIRIIKNLRVCLDCHTVTKLISKITERVIVVRDANRFHHFKDGVCSCGDYW
Protein: Kinesin-like protein (G5EG83)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSSRKRGITPSRDQVRRKKLSIEETDSIEVVCRLCPYTGSTPSLIAIDEGSIQTVLPPAQFRRENAPQVEKVFRFGRVFSENDGQATVFERTSVDLILNLLKGQNSLLFTYGVTGSGKTYTMTGKPTETGTGLLPRTLDVIFNSINNRVEKCIFYPSALNTFEIRATLDAHLKRHQMAADRLSTSREITDRYCEAIKLSGYNDDMVCSVFVTYVEIYNNYCYDLLEDARNGVLTKREIRHDRQQQMYVDGAKDVEVSSSEEALEVFCLGEERRRVSSTLLNKDSSRSHSVFTIKLVMAPRAYETKSVYPTMDSSQIIVSQLCLVDLAGSERAKRTQNVGERLAEANSINQSLMTLRQCIEVLRRNQKSSSQNLEQVPYRQSKLTHLFKNYLEGNGKIRMVICVNPKPDDYDENMSALAFAEESQTIEVKKQVERMPSERIPHSFFTQWNSELDGSVRMEDDGSREIPCPPTFCLTDCNDKDTVDSMYKYARKLSSLQNSSEEGPSSTLLTMIRQYMMEADYQRVEIARLKDSLNDKDEEIKKLRGFCSRYKRENASMKERIASCEQGEQENALVMEKLMEQKMEDRKIIQSQKKAMRNVRGIIDNPSPSVASLRSRFDQENVAHPTAPIQTPPPPYQTPGRAPVFKKRLEATTSTTVMSGSSSGGSGQQGYVNPKYQRRSKSASRLLDHQPLHRVPTGTVLQSRTPANAIRTTKPEMHQLNKSGEYRLTHQEVDDEGNISTNIVKGNVIPTVSGGTAVFFNDIERLTHESPSTRK