wanglab/gogpt-training-data huggingface dataset:
Protein: DNA-binding transcriptional activator HyfR (Hydrogenase-4 transcriptional activator) (P71229)
Organism: Escherichia coli (strain K12)
Function: A transcriptional activator of its own operon; when overexpressed operon expression is strongly enhanced by low pH (under pH 6.0), strongly inhibited by O(2) but only weakly stimulated by fumarate. Expression in situ is very weak.
Interaction partners:
- Hydrogenase-4 component J
- Formate channel FocB
- Hydrogenase-4 component A
- RNA polymerase sigma-54 factor
- Hydrogenase-4 component G
- Hydrogenase-4 component H
- Hydrogenase-4 component E
- Hydrogenase-4 component I
- Hydrogenase-4 component D
- Hydrogenase-4 component F
Sequence:
MAMSDEAMFAPPQGITIEAVNGMLAERLAQKHGKASLLRAFIPLPPPFSPVQLIELHVLKSNFYYRYHDDGSDVTATTEYQGEMVDYSRHAVLLGSSGMAELRFIRTHGSRFTSQDCTLFNWLARIITPVLQSWLNDEEQQVALRLLEKDRDHHRVLVDITNAVLSHLDLDDLIADVAREIHHFFGLASVSMVLGDHRKNEKFSLWCSDLSASHCACLPRCMPGESVLLTQTLQTRQPTLTHRADDLFLWQRDPLLLLLASNGCESALLIPLTFGNHTPGALLLAHTSSTLFSEENCQLLQHIADRIAIAVGNADAWRSMTDLQESLQQENHQLSEQLLSNLGIGDIIYQSQAMEDLLQQVDIVAKSDSTVLICGETGTGKEVIARAIHQLSPRRDKPLVKINCAAIPASLLESELFGHDKGAFTGAINTHRGRFEIADGGTLFLDEIGDLPLELQPKLLRVLQEREIERLGGSRTIPVNVRVIAATNRDLWQMVEDRQFRSDLFYRLNVFPLELPPLRDRPEDIPLLAKHFTQKMARHMNRAIDAIPTEALRQLMSWDWPGNVRELENVIERAVLLTRGNSLNLHLNVRQSRLLPTLNEDSALRSSMAQLLHPTTPENDEEERQRIVQVLRETNGIVAGPRGAATRLGMKRTTLLSRMQRLGISVREVL
Protein: serine C-palmitoyltransferase (EC 2.3.1.50) (Q9U912)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGNFDGDSGTVFEQSYATTNGNGKVPNGNGAADLSAPEKQELLRKFSAPAYTEIRTRRCQPKPANDAQSPSSINYHPEKKSIPNGDASILDQESKPNQAEGKLSPELEHFQKTSFEEVPLHTACLTYLGFYLLMILGYINQLLFVPKVATEKGRDGYVALYDAFESFYSRYVYRRIKDCWNRPICSVPGDELTLKDRVTDDYGWSFKFTGTETRCLNLGSYNYLGFAAATGQCADDSEESARSSGLAYCSSRCELGDNEQLQELEALTARYFGVEDAIVFGMGFATNALNLPSLLGPNSLVISDEKNHASIILGLRLSGATTKVFKHNNMRDLERVLRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGSIVRLPEVIALKKKYKAYLYLDEAHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFTKSFGSAGGYLAGSKKLIDFLRTNSHAHCYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRLAQLGVITYGHEDSPVVPMLVYLFSKIGAVVRTLTTRHIAAVGAGFPATPIMEGRIRFCLSAAHTKEQLDFALEAIDEIADDLGLKYSRKPRDPNPVIY
Protein: ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ) (O34748)
Organism: Bacillus subtilis (strain 168)
Function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with RecS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks.
Subcellular location: Cytoplasm, nucleoid {ECO:0000269|PubMed:16385024, ECO:0000269|PubMed:17853894}. Note=Localized throughout the nucleoid in the presence or absence of DNA double-strand breaks (PubMed:16385024). Another study finds it localized in tight foci to the chromosome replication center at mid-cell during most to all of the cell cycle (PubMed:17853894). {ECO:0000269|PubMed:16385024, ECO:0000269|PubMed:17853894}.
Interaction partners:
- Single-stranded-DNA-specific exonuclease RecJ
- Protein RecA
- DNA topoisomerase 3
- Nuclease SbcCD subunit C
- ATP-dependent DNA helicase PcrA
- ATP-dependent DNA helicase RecG
- DNA topoisomerase 1
- DNA replication and repair protein RecF
- DNA polymerase I
- DNA repair protein RecO
Sequence:
MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGGGKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLNGLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEILFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKDRFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERFLNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLFSPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACGQCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLSTYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEALKAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKGVGEQKRAKYGRLFLQEIQAYARMTD
Protein: Zinc finger transcription factor pqm-1 (CePqM132) (Paraquat responsive protein) (G5EFY7)
Organism: Caenorhabditis elegans
Function: Zinc finger transcription factor which acts as both a transcriptional activator and repressor. Binds to the promoters of genes that contain the 5'-CTTATCA-3' DNA consensus sequence in their regulatory region. Functions downstream of the Insulin/IGF-1-like signaling (IIS) mediated pathway. Involved in normal development, lifespan, stress response, lipid metabolism, innate immunity and exit from the developmentally arrested larval state known as dauer. Required for stress-induced expression of hsp-90 and resistance to heat stress, perhaps as part of a systemic stress signaling pathway. Involved in maintenance of proteostasis. Under hypoxic stress increases lipid levels by positively regulating fatty acid synthesis via fat-7 expression. Associates with homeobox protein ceh-60 at the promoters of some stress-responsive genes to regulate expression; may require phosphorylation for transcriptional repression activity. Acts downstream of nhr-14 to activate transcription of intestinal metal transporter smf-3, modulating innate immunity and iron uptake. May act downstream of the mTORC2 signaling mediated pathway. May act in a mutually exclusive manner with the FOXO transcription factor daf-16.
Subcellular location: Chromosome {ECO:0000269|PubMed:30956009}. Nucleus {ECO:0000269|PubMed:23911329, ECO:0000269|PubMed:29949773, ECO:0000269|PubMed:31532389}. Cytoplasm {ECO:0000269|PubMed:23911329, ECO:0000269|PubMed:31532389}. Note=Nuclear localization under normal conditions, cytoplasmic as a result of heat-stress (PubMed:23911329). Nuclear localization declines over normal lifespan (PubMed:23911329). Exposure to Gram-negative bacterium P.aeruginosa enhances nuclear localization (PubMed:31532389). Hypoxic stress enhances nuclear localization (PubMed:33009389). {ECO:0000269|PubMed:23911329, ECO:0000269|PubMed:31532389, ECO:0000269|PubMed:33009389}.
Interaction partners:
- Forkhead box protein O
- Transcription factor elt-3
- Homeobox protein ceh-60
- Insulin-like receptor
- Mad-like protein 1
- Transcription factor elt-2
- B lymphocyte-induced maturation protein 1 homolog
- Homeobox protein unc-62
- Defective pharyngeal development protein 4
- Cubilin
Sequence:
MSFLNNDFGSPPATSSPPTTMPKLPTIQDMLNNIGASTVNLMQPNPYLMQNQIPLPVPNLPLNPFLHLNPAISQEIIQQFIAMSFNTPNVLASIANMGDDEGPSCNPKMRRGDLLKSVSMDSTEDPPSITLDNNGDMIVPNNDKEGWCRNKKYIEQTENGYMCTVCRKVYGRYNSVSYHVTIYHRNPPIKCNVPNCQFTTREARYIHFHKNYRHGIPLPESIDQGSRKCPHCRHVSKSPAMLEKHIRRHQIKDGLSNINEAIRERTSTICDEAMEIEPAETEVDPIETKPRSCTL
Protein: Calcium up-regulated protein F (Q7Z1I0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May play an important role in stabilizing and/or regulating the cell membrane during Ca(2+) stress or certain stages of development.
Subcellular location: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Predicted HD phosphohydrolase family protein
Sequence:
MINIKDISKSSNQSEEKSLKGTSSKTKYPFAAKSLFKGSNNITPYYLSTSNTFQCVASESIQTWLLSDDGHIFTSSGNFVLDVSSGGYFVELVQLNSNSKTQIWTIDTTNNKIQNQGNGKYLDIDNLKICVAPLNGNATQKWTTFRRAPIPTGNWGYFQSKQLDSNNNYWGLSVLNNSKSYNTSVVMNKVQAKSIGQIWQMTNDGHILSRLDGNLVLDIGPSINGSKTNYYLDTNVYKANDLKQQWGINENNQIFNQYYPNLCIGFVGELGVDSTVNCVLAQPSSASDINFQWITNPTYSLNEIVSEVPEPFPAYTSGDLLASYQYISNIATNGHTDDIRSLYTSINVSLEIFYVNVTNATCPSSIHSTEDFSNVQNQIKNELTYAITVRLVFENYSGFYSKLFSQGSTNLTNLANLINVDMSSDQVVNGDYTDAITSVFYAIISEIPIGGSIIANIGESAVEFGELYAESNDSGPSTYQVTLSKLYDHLNENYENEMTNAQSMKNTILQDWGMMSKTFALCFLPTKNPSSLNINGLDFQKISTIASLAYQTAMIQMLLPTNYQIYFTPAGYYAPVSSDDYSYTDSTGTYIMAEIDNCNSYPPKALTDKLWNNGVSKQEVFTSSYGWNLATSVTYYNMVDKYSGMFKLSFPTVKNFTSVPMQFVMTNGSDRVGTFNVKTHFAGLASTYYYSGALGHHYYDIAVTDIDGNKVANFTVDNNLEALEGSYVSIKTGSLVVQPGYVVGNPTCNQGSFSQGFAASILIPIYKSN
Protein: ABC-type oligopeptide transporter ABCB9 (EC 7.4.2.6) (ATP-binding cassette sub-family B member 9) (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (TAP-like protein) (TAPL) (Q9QYJ4)
Organism: Rattus norvegicus (Rat)
Function: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q9NP78}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NP78, ECO:0000255|PROSITE-ProRule:PRU00441}. Note=May be located in membrane rafts. Takes an intracellular route from the endoplasmic reticulum (ER), via Golgi and early endosomes to late endosomal and lysosomal compartments. {ECO:0000250|UniProtKB:Q9NP78}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit alpha-3
- Sodium/potassium-transporting ATPase subunit beta-3
- Sodium/potassium-transporting ATPase subunit gamma
- FXYD domain-containing ion transport regulator 4
- Antigen peptide transporter 2
- TAP binding protein
- ATP-binding cassette sub-family G member 5
- ATP-binding cassette sub-family G member 8
- Sodium/potassium-transporting ATPase subunit alpha-2
- Sodium/potassium-transporting ATPase subunit beta-2
Sequence:
MRLWKAVVVTLAFVSMDVGVTTAIYAFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMAKLLLFSEVRRPIRDPWFWALFVWTYISLAASFLLWGLLATVRPDAEALEPGNEGFHGEGGAPAEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDSIVIQKSMDQFTTAVVVVCLLAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQSALARASTTAEETISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSYVWGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGRLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGEPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLEHPLDYTAGHKEPPSNTEHKA
Protein: Golgin B1 (Q3U286)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
SHGEWLTPRGASTVAPCLGYRADVASIGRGASGVGWDGRLQVSGSRRLRGELRNGSAASPGPRGSGHGSAGRPAPHLRAPPPSPARPRWSPSARRRTRPGDTDTQSVCRQGRSSPGSPGGGRAGQPYVHGRPCVRAAWASQPGHRAGDARGNLPQPCARPSPEQT
Protein: F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2) (Q6PFY1)
Organism: Mus musculus (Mouse)
Function: Promotes actin polymerization mediated by SNX9 and WASL.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26567222, ECO:0000305|PubMed:23437151}. Perikaryon {ECO:0000269|PubMed:26567222}. Cell projection {ECO:0000269|PubMed:26567222}. Cytoplasmic vesicle {ECO:0000269|PubMed:26567222}. Note=Detected on neuronal cell bodies and cell projections, in part on cytoplasmic vesicles. {ECO:0000269|PubMed:26567222}.
Interaction partners:
- Intersectin-1
- Intersectin-2
Sequence:
MQPPPRKVKPAQEVKLRFLEQLSILQTRQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGQRSGEADSRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKEQVLRKGTESLQQAQAEVLQSVRELSRSRKLYGQRQRVWALAQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLSAQSAQYSQQLRAARNEYLLNLVATNAHLAHYYQEELPALLKVLVSELSEYLRDPLTLLGHTELEAAEMILEHARHGGKATSQVNWEQDVKLFLQGPGVFSPTPPQQFQPAGADQVCGLEWGAGGMAGESGLEKEVQRWTSRAARDYKIQHHGHRVLQRLEQRRQQAPGREAPGVEQRLQEVRENIRRAQVSQVKGAARLALLQEAGLDVQRWLKPAMTQAQDEVEQERRLSEARLSQRDLSPTAEDAELSDFDECEEAGELFEEPAPPALATRPLPCPAHVVFGYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEAGFVPERYLNFPDLSLPESCHGIDNPSGGEPTAFLARALYSYTGQSEEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGHVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTCALDGSTAPALPSDKVLDCPGPLDMMVPRLRPMRPPPPPPAKAPDPGHPDPLT
Protein: PWWP domain-containing protein 2A (Q96N64)
Organism: Homo sapiens (Human)
Function: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes. Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z. Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression.
Subcellular location: Nucleus {ECO:0000269|PubMed:28645917}.
Interaction partners:
- Histone-binding protein RBBP4
- Histone deacetylase 1
- Histone H2A.Z
Sequence:
MAAVAAEAAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPDGETDGQQSAPQADEPPLPPPPPPPGELARSPEAVGPELEAEEKLSVRVAESAAAAPQGGPELPPSPASPPEQPPAPEEREEPPLPQPVAPALVPPAGGDSTVSQLIPGSEVRVTLDHIIEDALVVSFRFGEKLFSGVLMDLSKRFGPHGIPVTVFPKREYKDKPEAMPLQSNTFQEGTEVKCEANGAVPDDPSPVPHPELSLAESLWTSKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKRKMYREEPTSIMNAIKLRPRQVLCDKCKNSVVAEKKEIRKGSSATDSSKYEDKKRRNESVTTVNKKLKTDHKVDGKNQNESQKRNAVVKVSNIAHSRGRVVKVSAQANTSKAQLSTKKVLQSKNMDHAKAREVLKIAKEKAQKKQNETSTSKNAHSKVHFTRRYQNPSSGSLPPRVRLKPQRYRNEENDSSLKTGLEKMRSGKMAPKPQSRCTSTRSAGEAPSENQSPSKGPEEASSEVQDTNEVHVPGDQDEPQTLGKKGSKNNISVYMTLNQKKSDSSSASVCSIDSTDDLKSSNSECSSSESFDFPPGSMHAPSTSSTSSSSKEEKKLSNSLKMKVFSKNVSKCVTPDGRTICVGDIVWAKIYGFPWWPARILTITVSRKDNGLLVRQEARISWFGSPTTSFLALSQLSPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFET
Protein: Mitochondrial glutathione transporter SLC25A39 (Solute carrier family 25 member 39) (Q9D8K8)
Organism: Mus musculus (Mouse)
Function: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Transmembrane protein 14C
- Iron-sulfur cluster assembly 1 homolog, mitochondrial
Sequence:
MDDQDPGGISPLQQMVASGAGAVVTSLFMTPLDVVKVRLQSQRPSATSELTTPSRFWSLSYTKSSSALQSPGKCLLYCNGVLEPLYLCPNGTRCATWFQDPTRFTGTLDAFVKIVRHEGTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGQSLTSDLYAPMVAGALARMGTVTVVSPLELVRTKLQAQHVSYRELASSVQAAVTQGGWRSLWLGWGPTALRDVPFSALYWFNYELVKSWLSGLRPKDQTSVGISFVAGGISGMVAATLTLPFDVVKTQRQMSLGAVEAVRVKPPRVDSTWLLLRRIRAESGTRGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQEQPLGR
Protein: Transcription factor bHLH89 (Basic helix-loop-helix protein 89) (AtbHLH89) (bHLH 89) (Transcription factor EN 24) (bHLH transcription factor bHLH089) (Q9LND0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor DYT1
- Short-chain dehydrogenase reductase ATA1
- Transcription factor MYB35
- Ethylene-responsive transcription factor ERF098
- Transcription factor MYB80
- ATA20 protein
- 3-ketoacyl-CoA synthase 7
- Protein EXORDIUM-like 6
- Cytochrome P450 703A2
- Chaperone protein dnaJ 72
Sequence:
MGGGGMFEEIGCFDPNAPAEMTAESSFSPSEPPPTITVIGSNSNSNCSLEDLSAFHLSPQDSSLPASASAYAHQLHINATPNCDHQFQSSMHQTLQDPSYAQQSNHWDNGYQDFVNLGPNHTTPDLLSLLQLPRSSLPPFANPSIQDIIMTTSSSVAAYDPLFHLNFPLQPPNGSFMGVDQDQTETNQGVNLMYDEENNNLDDGLNRKGRGSKKRKIFPTERERRVHFKDRFGDLKNLIPNPTKNDRASIVGEAIDYIKELLRTIDEFKLLVEKKRVKQRNREGDDVVDENFKAQSEVVEQCLINKKNNALRCSWLKRKSKFTDVDVRIIDDEVTIKIVQKKKINCLLFVSKVVDQLELDLHHVAGAQIGEHHSFLFNAKISEGSSVYASAIADRVMEVLKKQYMEALSANNGYHCYSSD
Protein: Killer cell lectin-like receptor subfamily A member 9 (Killer cell lectin-like receptor subfamily A, member 9) (Natural killer cell recptor Ly49C) (Q2TJJ8)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- H-2 class I histocompatibility antigen, D-B alpha chain
- H-2 class I histocompatibility antigen, K-B alpha chain
- Killer cell lectin-like receptor 8
Sequence:
MNEPEVTYSTVRLHKSSGLQKLVRHEETQGPREAGNRKCSVSWQLIVKALGILCFLLLVIVAVLTIKIFQYSQHKQEINETLNHYHNCSNMQSDFNLKEEMLTNKSIDCRPSNELLDYIKREQDRWNSETKTVLDSSRDTGRGVKHWFCYGTKCYYFIMNKTTWSGCKANCQHYSVPIVKIEDEDELKFLQRHVIPESYWIGLSYDKKKKEWAWIDNGQSKLDMKTRKMNFKSRGCVFLSKARIEDTDCNIPYYCICGKKLDKFPD
Protein: Nucleolar RNA-binding protein (Q57YF5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosome biogenesis protein BOP1 homolog
- Nucleolar complex protein 2
- RNA processing factor 1, putative
- Putative rRNA methyltransferase
- rRNA methyltransferase, putative
- Ribosome assembly factor mrt4
- Ribosome biogenesis protein NSA1
- Ribosome biogenesis regulatory protein
- rRNA processing protein, putative
- Uncharacterized protein
Sequence:
MEGFYGVEVSAGQKVKPKIPEDHVLRLTQIAVPANASGAITLVISFQGKEFTIATLDPKRSLFQMGIDLVLTAEQGTTLSATGSGSVHLTGYVQPVDDGSDFDEEDDLDEVDAEDMESYGVPPKRGGKSAKFPVSEENSDEANGDGVDGDDESDDEEGIEKDNEGIDAGDEDDNDDDDEAYDEDDSDDDDDDDDDEEDDNDNDNDDDDDDDDDDDDDDDDDDEPASKVQRTEQQGFRGGNRGGFRGGDRNGNGGNRGGFRGGDRGGNRGNFRGGDRSGNGGNRGNFRGGDRGGNRGNFRGGDRGGNRGNFRGGNRGNFRGGNSGRGRY
Protein: SD04909p (Q95R61)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MRVEAFENAANAQNSMRPKRGKDLQGTPGSNNTPKIGKLPAPTVGRFFTPTQTTSTLPLSSAQPKKGPASASKATSLLKTATGTNLRSVNSTSTKTLSRENSGDDFRKGLHNLAEERKKLREQKHQQAAQQREAKERERAERMAKLAAERAKKQEERKRIEERKRQELEELQRKMRQQEEAEALKKAKHKELEQQKLQQLTGAKPKKMLPPPPKTKYTWEMLHEDDSTDDEGKVTHKRPPAPTWSRSHVRGEAIAMQSHCPTDIIDSFFSVAPTTPDLKQIFPNIDPSQLKRNSSVLWSTPPRYSELPKY
Protein: Hepatitis A virus cellular receptor 1 (HAVcr-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM-1) (T-cell membrane protein 1) (CD antigen CD365) (O46598)
Organism: Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Function: Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (By similarity). Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q96D42}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q96D42}.
Interaction partners:
Sequence:
MADPIMHLQVVILSLILHLADSVADSVNVDGVAGLSITLPCRYNGAITSMCWNRGTCSVFSCPDGIVWTNGTHVTYRKETRYKLLGNLSRRDVSLTIANTAVSDSGIYCCRVKHSGWFNDMKITISLKIGPPRVTIPIVRTVRTSTTVPTTTTTTLPTTTTLPTTTTLPTTMTLPTTTTLPMTTTLPTTTTVPMTTTLPTTLPTTTTLPTTLPTTTTLPTTLPTTTTLPTTMTLPMTTTLPTTTTLPTTTTLPTTTTLPTTTTLPTTTLPTMTLPTTTTLPTTMTLPMTTTLPTTTTLPTTTTLPTTTMVSTFVPPTPLPMQDHEPVATSPSSAQPAETHPVTLLGATRTQPTSSPLYSYTTDGSDTVTESSDGLWNNNQTQLSPEHSPQMVNTTEGIYAGVCISVLVLLAVLGVVIAKKYFFKKEIQQLSVSFSNHQFKTLQNAVKKEVHAEDNIYIENNLYAMNQDPVVLFESLRP
Protein: GTPase-activating protein MSB4 (Multicopy suppressor of bud emergence 4) (Q12317)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulates exocytosis by functioning as a GAP for SEC4. Also required for efficient polarization of the actin patches.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10679030}. Bud {ECO:0000269|PubMed:10679030}. Bud neck {ECO:0000269|PubMed:10679030}. Note=Localizes to the presumptive bud site, the bud tip and the mother-bud neck.
Interaction partners:
- Protein SPA2
- Bud site selection protein 6
- Protein BNI1
- Protein PEA2
- GTPase-activating protein GYP3
- Ras-related protein SEC4
- Cell division control protein 42
- GTPase-activating protein GYP1
- GTPase-activating protein GYP7
- Protein PNS1
Sequence:
MIMSSTMSTEAALVPNESVFDTVSSFNEDDANYSVLDLYDDDDEGDDSSTVERKEILTTRELEKAKAFTSLIMADPENFDRYGFSKKGYFISQEEYDKWWTEYNRYTERRKKKWENFLLKNKIELHNDNPLVYPARTDELSKFVRKGIPAEWRGNAWWYFAGGQRQLDANVGVYDRLKSDCREGAVSGKDMEAIERDLYRTFPDNIHFHKESFQNGEPAIIRSLRRVLMAFSVYDKTIGYCQSMNFLVGLLLLFMEEEKAFWMLVIITGKYLPGVYESDLEGANVDQGVLVLCIKEYLPEIWSHIESSYMNGNGSTDQISGPASGEEYLCRLPTLTLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHFLFKVALGILKLSESEFLESKSQKLFRQYSSYTFGGSNDSDSTFKRLKNKIKTQEEADMEILQVIQNFPKRLLNPNDIFEKVLMKKKVALNGITQEKIDRGREYVAMARNRQRASSRPKERRK
Protein: Catenin delta 1 (C9JZR2)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
Interaction partners:
Sequence:
MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMKI
Protein: Interleukin (Q06E04)
Organism: Gallus gallus murghi
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MMCKVLIFGCISVAMLMTTAYGASLSSEKWKTLQTLIKDLEILENIKNKIHLELYTPTETQECTQQTLQCYLGEVVTLKKETEDDTEIKEEFVTAIQNIEKNLKSLTGLNHTGSECKICEANNKKKFPDFLHELTNFVRYLQK
Protein: 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (cAMP-specific phosphodiesterase 4A) (O89084)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P27815}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P27815}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Deoxycytidine kinase
- Adenine phosphoribosyltransferase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- GTP:AMP phosphotransferase AK3, mitochondrial
- Adenylosuccinate lyase
- Adenylate cyclase type 3
Sequence:
MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERSEPERSPHRPIERADAVDTGDRPGLRTTRMSWPSSFHGTGTGGGSSRRLEAENGPTPSPGRSPLDSQASPGLMLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVASEAHGEDLIVTPFAQVLASLRNVRSNFSLLTNVPIPSNKRSPLGGPPSVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTPRQRPFQQPPPAAVQQAQPMSQITGLKKLVHTGSLNINVPRFGVKTDQEDLLAQELENLSKWGLNIFCVSEYAGGRSLSCIMYTIFQERDLLKKFHIPVDTMMTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRDWYHSAIRQSPSPTLEEEPGVLSDPALPDKFQFELTLEEEDEEDSLEVPGLPCTEETLLAPHDTRAQAMEQSKVKGQSPAVVEVAESLKQETASAHGAPEESAEAVGHSFSLETSILPDLRTLSPSEEAQGLLGLPSMAAEVEAPRDHLAAMRACSACSGTSGDNSAVISAPGRWGSGGDPA