wanglab/gogpt-training-data huggingface dataset:
Protein: Short-chain dehydrogenase, putative (Q57VE2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Putative enoyl-CoA reductase
- very-long-chain
- Fatty acid desaturase, putative
- 3-oxoacyl-
- Fatty acid desaturase, putative
- Fatty acid elongase 1
- Vacuolar transporter chaperone complex subunit 1
- inorganic diphosphatase
- inorganic diphosphatase
- cysteine desulfurase
Sequence:
MLFDCTLLSLLGAMVAAIGLYRVVQFVHLTFFSTGHDLKRRYSKAGDWAVVTGGTEGIGRAVALDLANRGFNVCVISRTQSKLDEVVAEIEKCGTRGHSIAFDFATAGEAEYKMLFAKLDSLAVGLLVNNVGVNYTYANYFDEADVVDDLRIIKVNCEATTRMTKFFAPRMKARRAGGIVLLGSFSAVTPAPLLATYAGTKAFNVSFGDALFYELKKFGVDVLVVTPNLVVSRMTQGASTRAPKETFLTVGAAAMARQTLNQLGVVNRTAGHRNHIIIEAIARLLPESLRGEKMLAMHESIKKRAERKAKQ
Protein: NTF2-related export protein (Q9U757)
Organism: Caenorhabditis elegans
Function: Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Nuclear RNA export factor 2
- Nuclear RNA export factor 1
- Probable nuclear transport factor 2
- THO complex subunit 5
- WD_REPEATS_REGION domain-containing protein
- Death domain-containing protein
- THO complex subunit 7 homolog
- Transcriptional repressor NF-X1 homolog
- mRNA export factor rae-1
- RanBD1 domain-containing protein
Sequence:
MSMKTTQEINKEDEELCNESKKFMDVYYDVMDRKREKIGFLYTQVSNAVWNGNPINGYDSICEFMKALPSTQHDIQSLDAQRLPEGVTGDMSGGMLLNVAGAVTVDGDSKRAFTQTLLLGVEDGKYKVKSDRFRYVD
Protein: COX assembly mitochondrial protein (COX biogenesis factor CMC1) (Cx9C mitochondrial COX assembly protein 1) (Mitochondrial metallochaperone-like protein CMC1) (P36064)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. Binds copper. May be involved in copper trafficking and distribution to mitochondrial COX and SOD1.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:18443040, ECO:0000269|PubMed:19703468}; Peripheral membrane protein {ECO:0000269|PubMed:18443040, ECO:0000269|PubMed:19703468}; Intermembrane side {ECO:0000269|PubMed:18443040, ECO:0000269|PubMed:19703468}. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}. Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery.
Interaction partners:
- Cytochrome c oxidase assembly protein COX19
- Mitochondrial intermembrane space import and assembly protein 40
- Cytochrome c oxidase copper chaperone
- Mitochondrial import inner membrane translocase subunit TIM10
- Mitochondrial protein PET191
- mRNA-binding protein PUF3
- Mitochondrial intermembrane space cysteine motif-containing protein MIX14C motif protein of 14 kDa)
- Mitochondrial FAD-linked sulfhydryl oxidase ERV1
Sequence:
MEQNKDPQMISKHSSRLPIWVLSPREEQQARKNLKTETYKKCANFVQAMADCAKANGMKVFPTCDKQRDEMKSCLLFYQTDEKYLDGERDKIVLEKINKLEKLCQKQSSTK
Protein: HTH-type transcriptional regulator YidZ (P31463)
Organism: Escherichia coli (strain K12)
Function: Involved in anaerobic NO protection.
Interaction partners:
- Multidrug resistance protein MdtL
- Uncharacterized HTH-type transcriptional regulator YcaN
Sequence:
MKKSITTLDLNLLLCLQLLMQERSVTKAAKRINVTPSAVSKSLAKLRAWFDDPLFVNSPLGLSPTPLMVSMEQNLAEWMQMSNLLLDKPHHQTPRGLKFELAAESPLMMIMLNALSKQIYQRYPQATIKLRNWDYDSLDAITRGEVDIGFSGRESHPRSRELLSSLPLAIDYEVLFSDVPCVWLRKDHPALHQTWNLDTFLRYPHISICWEQSDTWALDNVLQELGRERTIAMSLPEFEQSLFMAAQPDNLLLATAPRYCQYYNQLHQLPLVALPLPFDESQQKKLEVPFTLLWHKRNSHNPKIVWLRETIKNLYASMA
Protein: Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) (P15105)
Organism: Mus musculus (Mouse)
Function: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia. Essential for proliferation of fetal skin fibroblasts (By similarity). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development. Involved in angiogenesis by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (By similarity). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P15104}. Microsome {ECO:0000250|UniProtKB:P09606}. Mitochondrion {ECO:0000250|UniProtKB:P09606}. Cell membrane {ECO:0000250|UniProtKB:P15104}; Lipid-anchor {ECO:0000250|UniProtKB:P15104}. Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane. {ECO:0000250|UniProtKB:P15104}.
Interaction partners:
- Glutamate dehydrogenase 1, mitochondrial
- Glutaminase kidney isoform, mitochondrial
- Glutaminase liver isoform, mitochondrial
- Amidophosphoribosyltransferase
- Carbamoyl-phosphate synthase, mitochondrial
- Receptor-interacting serine/threonine-protein kinase 3
- Glutamine--fructose-6-phosphate aminotransferase 1
- Glutamine--fructose-6-phosphate aminotransferase 2
- Glutamate decarboxylase 1
- Glutamate decarboxylase 2
Sequence:
MATSASSHLNKGIKQMYMSLPQGEKVQAMYIWVDGTGEGLRCKTRTLDCEPKCVEELPEWNFDGSSTFQSEGSNSDMYLHPVAMFRDPFRKDPNKLVLCEVFKYNRKPAETNLRHICKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADKAYGRDIVEAHYRACLYAGVKITGTNAEVMPAQWEFQIGPCEGIRMGDHLWIARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKCIEEAIDKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPYAVTEAIVRTCLLNETGDEPFQYKN
Protein: Oocyte-secreted protein 2 (Placenta-specific 1-like protein) (Protein TMEM122) (Q86WS3)
Organism: Homo sapiens (Human)
Function: Involved in oocyte maturation.
Subcellular location: Secreted {ECO:0000269|PubMed:36042231}. Cytoplasm {ECO:0000269|PubMed:31429579}.
Interaction partners:
- Oocyte-secreted protein 3
- Putative oocyte-secreted protein 1 homolog
Sequence:
MALEVLMLLAVLIWTGAENLHVKISCSLDWLMVSVIPVAESRNLYIFADELHLGMGCPANRIHTYVYEFIYLVRDCGIRTRVVSEETLLFQTELYFTPRNIDHDPQEIHLECSTSRKSVWLTPVSTENEIKLDPSPFIADFQTTAEELGLLSSSPNLL
Protein: FOS-like 2, AP-1 transcription factor subunit (Fos-related antigen 2 isoform 1) (Zgc:158347 protein) (A2RUX8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- JunB proto-oncogene, AP-1 transcription factor subunit b.
- JunB proto-oncogene, AP-1 transcription factor subunit a.
- Transcription factor JunD
- Transcription factor Jun
- JunE proto-oncogene, AP-1 transcription factor subunit
- FBJ murine osteosarcoma viral oncogene homolog B
- Protein c-Fos
- FOS-like 1, AP-1 transcription factor subunit a
Sequence:
MYQDYTGTYDTSSRGSSSSPAHPDTSPIPASSYQKYRIDMPGSSSAFIPTINAITTSQDLQWMVQPTVITSMSNPYSRPHPYGLSVSSGPSLLGHTALTRPGVIRSIGDARGRRKRDEQLTPEEEEKRRVRRERNKLAAAKCRNRRRELTEMLQGETEKLEEEKADLQKEIETLQKEKDKLEFMLVAHNPVCKLPPEERHQSSHSQQCVPLPLTMRSNLVPRGPMNTLNPVVVKQEPLEDDDDDEDDDDEEEKVQHSVIKPICLGGGMYCSDGDSLNTPVVAASTPVSTPNNPSLIFTYPSMLEPESPSPSSESCSKAHRRSSSSGDQSSDSLNSPTLLAL
Protein: Cysteine-rich protein 2 (CRP-2) (Protein ESP1) (P52943)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASKCPKCDKTVYFAEKVSSLGKDWHKFCLKCERCSKTLTPGGHAEHDGKPFCHKPCYATLFGPKGVNIGGAGSYIYEKPLAEGPQVTGPIEVPAARAEERKASGPPKGPSRASSVTTFTGEPNTCPRCSKKVYFAEKVTSLGKDWHRPCLRCERCGKTLTPGGHAEHDGQPYCHKPCYGILFGPKGVNTGAVGSYIYDRDPEGKVQP
Protein: Protein N-terminal and lysine N-methyltransferase efm7 (EC 2.1.1.-) (Elongation factor methyltransferase 7) (Q9UT28)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03223}.
Interaction partners:
- Protein-lysine N-methyltransferase efm4
- UPF0665 family protein C23C4.06c
Sequence:
MADNDFEGFGIFEEPEGFRPSTPPPKEVLHTRVIVPNGPEEIKLRLVGSHSLWAHYLWNSGIELANYIDKNPDTVRAKKVLELGAGAGLPSIVSAFDGAKFVVSTDYPDPALIDNLEHNVKQYAEIASKISAVGYLWGSNIKEVMSNAGFKDNEVFDILLLSDLVFNHTEHSKLIKSCKMAIEGNPNAVVYVFFTHHRPHLAKKDMIFFDIAQSEGFQIEKILEEKRTPMFEEDPGAPEIRATVHGYKMTIPIPV
Protein: Nucleosome assembly protein 1-like 3 (Q99457)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Nucleosome assembly protein 1-like 2
Sequence:
MAEADFKMVSEPVAHGVAEEEMASSTSDSGEESDSSSSSSSTSDSSSSSSTSGSSSGSGSSSSSSGSTSSRSRLYRKKRVPEPSRRARRAPLGTNFVDRLPQAVRNRVQALRNIQDECDKVDTLFLKAIHDLERKYAELNKPLYDRRFQIINAEYEPTEEECEWNSEDEEFSSDEEVQDNTPSEMPPLEGEEEENPKENPEVKAEEKEVPKEIPEVKDEEKEVPKEIPEVKAEEKADSKDCMEATPEVKEDPKEVPQVKADDKEQPKATEAKARAAVRETHKRVPEERLQDSVDLKRARKGKPKREDPKGIPDYWLIVLKNVDKLGPMIQKYDEPILKFLSDVSLKFSKPGQPVSYTFEFHFLPNPYFRNEVLVKTYIIKAKPDHNDPFFSWGWEIEDCKGCKIDWRRGKDVTVTTTQSRTTATGEIEIQPRVVPNASFFNFFSPPEIPMIGKLEPREDAILDEDFEIGQILHDNVILKSIYYYTGEVNGTYYQFGKHYGNKKYRK
Protein: Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) (P25446)
Organism: Mus musculus (Mouse)
Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P51867}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P51867}. Membrane raft {ECO:0000250|UniProtKB:P25445}.
Interaction partners:
- Caspase-8
- FAS-associated death domain protein
- Tumor necrosis factor ligand superfamily member 6
- Tumor necrosis factor ligand superfamily member 10
- Tumor necrosis factor
- Tumor necrosis factor receptor superfamily member 1A
- Death domain-associated protein 6
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- CASP8 and FADD-like apoptosis regulator
- FAS-associated factor 1
Sequence:
MLWIWAVLPLVLAGSQLRVHTQGTNSISESLKLRRRVRETDKNCSEGLYQGGPFCCQPCQPGKKKVEDCKMNGGTPTCAPCTEGKEYMDKNHYADKCRRCTLCDEEHGLEVETNCTLTQNTKCKCKPDFYCDSPGCEHCVRCASCEHGTLEPCTATSNTNCRKQSPRNRLWLLTILVLLIPLVFIYRKYRKRKCWKRRQDDPESRTSSRETIPMNASNLSLSKYIPRIAEDMTIQEAKKFARENNIKEGKIDEIMHDSIQDTAEQKVQLLLCWYQSHGKSDAYQDLIKGLKKAECRRTLDKFQDMVQKDLGKSTPDTGNENEGQCLE
Protein: Coiled-coil domain-containing protein 9B (Q6ZUT6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MISCAEQRSRQGEAGRGPAPVAPAFLPLWLPRGCSGILSVPAVAMHSAGTPRAESPMSRQEKDAELDRRIVALRKKNQALLRRYQEIQEDRRQAEQGGMAVTTPALLQPDGLTVTISQVPGEKRVVSRNWARGTCGPRVTNEMLEDEDAEDHGGTFCLGELVELAVTMENKAEGKRIVSEKPTRARNQGIEGSPGGRVTRSPPTQVAISSDSARKGSWEPWSRPVGEPPEAGWDYAQWKQEREQIDLARLARHRDAQGDWRRPWDLDKAKSTLQDCSQLRGEGPARAGSRRGPRSHQKLQPPPLLPDGKGRGGQASRPSVAPATGSKARGKERLTGRARRWDMKEDKEELEGQEGSQSTRETPSEEEQAQKQSGMEQGRLGSAPAASPALASPEGPKGESVASTASSVPCSPQEPDLAPLDLSLGGAGIPGPRESGCVLGLRPGAQESPVSWPEGSKQQPLGWSNHQAELEVQTCPEPQRGAGLPEPGEDRSGKSGAQQGLAPRSRPTRGGSQRSRGTAGVRRRTGRPGPAGRC
Protein: Acylalkylpyrone synthase csyB (EC 2.3.1.-) (Type III polyketide synthase csyB) (Q2U852)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Acylalkylpyrone synthase that catalyzes not only the polyketide chain elongation but also the one-pot condensation of two beta-ketoacyl units to produce the 3-acyl-4-hydroxy-6-alkyl-alpha-pyrone (AcAP) scaffold, a precursor of csypyrone B (Probable). The enzyme reaction is initiated by the loading of acetoacetyl-CoA onto Cys-155, and subsequent thioester bond cleavage by the nucleophilic water generates the beta-keto acid intermediate, which is placed within a pocket. The second beta-ketoacyl unit is then produced by polyketide chain elongation of fatty acyl-CoA with one molecule of malonyl-CoA, and the condensation with the beta-ketoacid generates the final products. Csypyrone B1 is the major product and contains a propanoic acid side-chain, whereas csypyrones B2 and B3 are minor compounds that contain butyric or pentanoic acid side-chains, respectively.
Interaction partners:
Sequence:
MIEPLPTEDIPKQSVSIVGIASRCAPHKLGADELEAIARRHYSSTPSLEKMLEINRKTRIDHRYSVFSSDHEHWHRPTIPSFSECDSLFKEYGIPLASAASARAIQDWGGVPDEITHLVAVTCTNTAHPGFDSVLCRKLGLKCNVRRVLLHGIGCGGGISAMRVAHELLLGSTQQGVPARALIVACEVPTVFARSELDIMDKTQDVNVAMCLFGDCAAALVLSNGIGHKASEQRPIWNILNCEPTQFDGTEDIAHFNVHDKGYHAIIDKRIPQLTGKCVPAGFQSLISSTPSLALEEKNYVPSNYGWAVHPGGYAVLVAAQDALGLTADDLRASYDAYRDGGNTISTTIIRILEKLRDEHKHGSNQKDKLVLAAIGHGITLETAILTRPGSSSYLHA
Protein: Protein IQ-DOMAIN 16 (AtIQD16) (Q7XA83)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking. Regulates cell shape and elongation in aerial organs (i.e. cotyledons, leaves, and hypocotyls) probably by regulating cortical microtubules (MT) arrays orientation. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:28115582}. Cell membrane {ECO:0000269|PubMed:28115582}. Note=Recruits calmodulin (CaM2) to microtubules. {ECO:0000269|PubMed:28115582}.
Interaction partners:
- IQ-domain 29
- Protein IQ-DOMAIN 33
- At1g23060/T26J12_16
- Protein KINESIN LIGHT CHAIN-RELATED 1
- Katanin p60 ATPase-containing subunit A1
Sequence:
MAKKNGTSWFTAVKKILWSPSKDSDKKTHHHKETDIKRKEKKGWIFRKTKLETTNSVLQHTVRTVEAEEKEKPPVIVSSVEEGVTEIVKLTATPGFIRRHWAAIIIQTAFRGYLSRRALRALKGIVKLQALVRGNNVRNQAKLTLRCIKALVRVQDQVLNHHQQQRSRVLLSPPSRNYNIEARRNSMFAESNGFWDTKTYLQDIRSRRSLSRDMNRCNNEFYSEETELILQKKLEIAIKREKAQALALSNQIRSRSSRNQSAGDDRELLERTQWLDRWMATKQWDDTITNSTNVRDPIKTLEAVTTHHHQRSYPATPPSCRASRSVMVRSASPRIPCSPSSMQPNYMSATESAKAKARTQSTPRRRPMTAKKRLCYAEEESLRSPSFKSCLWGDHESDYSCCYGDGFAGKISPCSTTELRWLK
Protein: Thermosome subunit gamma (Q949W7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- GAG1At protein
- Ribonuclease 3-like protein 2
- CAAX amino terminal protease family protein
Sequence:
MAVSSFAVLPPFGSSYSSTTDRSSSSSFYSSSKLLRISQYRFQSNSRCPNVFVSCSLNQPSDDASDAALFLESNSIADYMRFKRRPDPGNGTSELQTAIVSYKKRFPWILLNPFLQVDLVSTIHIADKEYFTTLQKELEPYDSILYEMVASKETLENRRNPIASKRLKSSRSRGFSILGFIQRQMARVLTLDFQLDCLDYDTENWYHADLDFETFQLLQKEKGESFFSFARDMTIRSTKAMIQPALVTEGRDTWRSKLLWVSRVFPMPLVGLFLIGAFCADFGDQTSDYPELEALSRLDFGAAMKVFLAKRLTSELTLETSDIEEKSVIIGERNRAATEALRRAIEQGHKRIGILYGGGHMPDLGRRLREEFDLVPSEVRWVTAWSIRNPTDLETSSYPILRKMAEALRWPLNRYQTLALLIFSSVLALDLCFWELFFGSTIDWATQIGAELYQFIDNTKIV
Protein: RPGR interacting protein 1 (A0A8I6A160)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
Sequence:
MLHLLDHMPEDRPVRDTDSIPLSKGTSGKNVKAQSRSGRMNREKLNYRPFQLHEDPMVVKELSPKQRDKSRRPRTNMKRSTTTQPDLRTLAVLQEPVRQRPPWVSASLRSLVTRHAQVPRRKAHMQRQCPSTAAGSTQSRVHVGRRPGPNDRRSHTAPPTFKDYVMDENPSMEVTSEPSQPTHIMTTDSTHAEETSRSPEKMSKVEKLEQRSSLECAEKAAELRATIKENVELIRLKKLLYERSASLAATEAQLTRVQEAYEDLLQKNQGILDATHDAFLSQVNELKAELSEESKKAVSLRIQLGDVSILQKTLKEFQVRVEDLESERKLLSDSYDRLLENMLESSHQPLESSHQPHWNRELMAEQLPQQVCPLLDQVGAELEETKVLLQVTNQVAQDEQLTFQVTSILCQHKQEEENLQSTATIPLFPEELFELAVQPTLLAQTVQRESSEPRVQEESSLSQVLNELQVSHAETALELEKTRDMLLLQRKINLCYQEELEATLTKADKENRDHEETMERLTHLLDFKNSRIMQLEGILRSHGLPTSEQLKDVAYGTRQPSLCLESPAAHRGEDEVDMSLLHPSENLFELHIHQAFLTPAALIQAGDAQPTTFCTYSFYDFETHCTPFCTGPQPLYDFTSQYVVQTDYLFLHHLHGTSVRLDLHQAMASEHQVLATGWISLDKVLETVERVHGLATLTGAGGEDLGVLEYWMRLCLPLKSSLQACNKRKKAQAYLSVNVLGGWKAQNDESRSEAWAPQNELRIEITRCCGLRSRWGGRQPSPYVMYRFFTFPDHATTVIPASSDPYFKDQALFPVPVTSDLDEYLRREALSLYVFDDEDPEPGSFLGRVQVPLLPLAQNKSLKGDFNLTDAGEMSNGSIQVQLDWKSHHLPPESLQMSEAEKPEEEEEEEEEDEEKEDEEEEGEEEEGEEKEEERKEEKEEEKEEEKEEEEEKEEEKEEEREEEEKEEEKEEEEEEEEEKEEENKDGLEVSFTEEQTPFLPQAQIASTEIPIEAGQYQEKRKPPVIAERKEKERQVTSYSRRKHSKKPGVQGKNRMEYLSCNILNGDIQQMRYTEWKFSGLKMYEDDGLKVQQKEEEQPSPHSALRQDQPSHSINASSPTDQESSEQASEVSEAHTPDSDDIVVTPQSQTCPKADSEKMCIEIVSLAFCPEADVMADENIRQVYVEYKFCDLPLSETETPVSLRKPRAGEEIHFHFSKVIDLDPVEHQDRRQFLFAMLQAQNSDEGRLKFTVVSDPLDEEKKECQDIGYAYLELWQIFQSGKDILEQELEIVSPGNQAIQIGRLKVSLQATAALHGIYKEMTEDLFS
Protein: Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (O35621)
Organism: Mus musculus (Mouse)
Function: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16847318}.
Interaction partners:
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- Mannose-1-phosphate guanylyltransferase regulatory subunit alpha
- Mannose-6-phosphate isomerase
- Phosphomannomutase 2
- Hexokinase-1
- Hexokinase-2
- Hexokinase HKDC1
- Hexokinase-3
Sequence:
MAVAVEGARRKERILCLFDVDGTLTPARQKIDPEVSAFLQKLRSRVQIGVVGGSDYSKIAEQLGEGDEVIEKFDYVFAENGTVQYKHGRLLSKQTIQNHLGEELLQDLINFCLSYMALLRLPKKRGTFIEFRNGMLNVSPIGRSCTLEERIEFSELDKKEKIREKFVEALKTEFAGKGLRFSRGGMISFDVFPEGWDKRYCLDSLDEDSFDIIHFFGNETSPGGNDFEIYADPRTVGHSVVSPQDTVQRCRELFFPETAHEA
Protein: Histone-lysine N-methyltransferase EZA1 (EC 2.1.1.356) (CURLY LEAF-like 1) (Protein SET DOMAIN GROUP 10) (Protein SWINGER) (Q9ZSM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes, mainly abscisic acid (ABA) responsive elements. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (By similarity). Forms a nuclear complex with CLF and HXK1 to target common glucose-responsive genes and regulate glucose signaling by glucose-mediated gene repression. Affects the recruitment of HXK1 to the target chromatin.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:35394700}.
Interaction partners:
- Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM
- Histone-binding protein MSI1
- Polycomb group protein VERNALIZATION 2
- Polycomb group protein EMBRYONIC FLOWER 2
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
- Lysine-specific demethylase ELF6
- VIN3-like protein 1
- Protein VERNALIZATION INSENSITIVE 3
- VIN3-like protein 2
- Putative E3 ubiquitin-protein ligase RING1a
Sequence:
MVTDDSNSSGRIKSHVDDDDDGEEEEDRLEGLENRLSELKRKIQGERVRSIKEKFEANRKKVDAHVSPFSSAASSRATAEDNGNSNMLSSRMRMPLCKLNGFSHGVGDRDYVPTKDVISASVKLPIAERIPPYTTWIFLDRNQRMAEDQSVVGRRQIYYEQHGGETLICSDSEEEPEPEEEKREFSEGEDSIIWLIGQEYGMGEEVQDALCQLLSVDASDILERYNELKLKDKQNTEEFSNSGFKLGISLEKGLGAALDSFDNLFCRRCLVFDCRLHGCSQPLISASEKQPYWSDYEGDRKPCSKHCYLQLKAVREVPETCSNFASKAEEKASEEECSKAVSSDVPHAAASGVSLQVEKTDIGIKNVDSSSGVEQEHGIRGKREVPILKDSNDLPNLSNKKQKTAASDTKMSFVNSVPSLDQALDSTKGDQGGTTDNKVNRDSEADAKEVGEPIPDNSVHDGGSSICQPHHGSGNGAIIIAEMSETSRPSTEWNPIEKDLYLKGVEIFGRNSCLIARNLLSGLKTCLDVSNYMRENEVSVFRRSSTPNLLLDDGRTDPGNDNDEVPPRTRLFRRKGKTRKLKYSTKSAGHPSVWKRIAGGKNQSCKQYTPCGCLSMCGKDCPCLTNETCCEKYCGCSKSCKNRFRGCHCAKSQCRSRQCPCFAAGRECDPDVCRNCWVSCGDGSLGEAPRRGEGQCGNMRLLLRQQQRILLGKSDVAGWGAFLKNSVSKNEYLGEYTGELISHHEADKRGKIYDRANSSFLFDLNDQYVLDAQRKGDKLKFANHSAKPNCYAKVMFVAGDHRVGIFANERIEASEELFYDYRYGPDQAPVWARKPEGSKKDDSAITHRRARKHQSH
Protein: Nitric oxide synthase (EC 1.14.13.39) (Q8AXU2)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
Sequence:
MKLLQDDETKLSHQTKPNKWETRANRCPFSIPVRNVKDGSSLKDMLHHQAVKNQPCTSKVCEGSVMTPKALLRGPKVSTLEILPQAIDLITQYYKSFKIPKIEHHLARLEEITMEIDSTGTYQLTVEELAFGARQAWRNAPRCIGRIQWSNLQLFDARKCKTTQEMFQFLCEHLQFATNGGNLRSAITVFPPRKEDGHDFRVWNSQLLKYAGYQMPDGSIQGDPSSVEFTKICIQLGWKPQYGLFDVLPLVLQVNGEDPDLYEIPPHLILEVSMEHPQHKWFQDLGLKWYALPAVSNMLMEIGGLEFPACPFNGWYMGTEIGVRDFCDYQRYNILEEVGRRMGLETHKLSSLWKDQALVTINVAVIYSFQKNKVTITDHHSAAESFMKHLETEFRLRGGCPADWAWLVPPMSGSLTPIFHQEMVNYILSPFFYYQHDPWMTHVWRNGEMCLKKHQISFKAVARAALFSSTLMSRVLAKRVRCTVLYATETGKSQTLAQRLNSMLNGAFNSRLLCMEDYNFSDMEQESLLVVVTSTFGNGDSPGNGESFKKQLFSLQYLRDKLRYCVFGLGSRMYPRFCAFAHAVDAKLEELGAERVTPTGEGDELNGQEEAFSAWAPTALKDAYKEFKIQGQLSLQLPGAERFCEAWDPLRHRVAVESCPQDRITALSAIHSKTVFPMKLKSKHNLQSPHSSRSTILVKLERERSAEVMNFAPGDHVGVFPGNLPQLVAGVLKFLPHTPPTNQCLRLEYRSNTCRDDEKNWQTVGRIPACPLSQALTYFLDVTTPPSQNLLHKLSQLAKQEGHRQRLLTLAKDSQEYTTWKMFRVPNFLEVLEEFPSLELSAAFLLSQLPLLKPRLYSISSSPQLHPNELHLTLTVLNYHTQDGQGPLHHGVCSTWLDTIKKGDLVPCFIYSSGGFHLPAEPSTPVILVGAGSGIAPFRSFWQQRLHDMKHPEFSESPMSLVFGCQSSETDHLYKEETLEMRRRGVLKSVTNAYSRQPGLPKVYVQDVLRERMAEEVLSVLHQKEGHFYVCGGVNMAQGVALAVQEILSSQLGITLTQAGEYLTQLKIQKRYHEDIFGAQFQK
Protein: BTB domain-containing protein (Q57YB9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWNEVSASEVEALLGELRDIVSDPVVMSVTKSGEDKQLISEEKTKPKAVGRVGFSTYASVTESRRTVVPLYERLPPITPPVVCSIRDELTMSGADTLRKGFLLLPNLTGDGEGMPQRPMSPNEVRRLLCCAESSARGGAANNSATSPTAGEGGDVKDSYREPNFLPIMCARHICPGGIVPRARWGHTLTAVQGHKLVLFGGMDLKEGDTSDLFEYDAHHVVWDPVFVADGVGPAPRTNHAACAAEDRWLYVSGGTTARGTIILGDIYRFDTWTHEWKCLWEYRGIGTSASNSTSKNEPTPRFGHSMLHRDGRLYIFGGRALKRNQSGSRGDAVTCMASTDVYVFSLTSGKWKKRIQAGKENTVSDEAKAPGSAGPCASERQESENAVELPPTRPTVRFHHAACIMDSTMFINGGVDGDSVTLADTWALNLKEGRWIRLHDGSTADAHPREKHHLFACGGCLLAVGGCSASDRRSLVSRRCRNFVAVLALESENKLGSVSWFPLAMGNAAAVVPNRKSFGAAFSGGFVHVFGGICGCEPPSNTMVRFLAADGYFATDSTMVPSSSAGNKEGAISMMRSVRESGDFVTYDAYILPRSWDGDVEVDTVANKPFGVHRALVQQRAPKFWEDVLRCRTSVAKSIISPIADASSQLVNFACNPGLAESGNADNPTVGSCNRAGCDEEPNQAHVTAYYTEGNSRVQGLSVSLTANQLQCLLDYIYWGDMHLSMLAELDDDNVSNRGREDLQKTAAQEEVRTVQSLMRAAEVYELPLLHALCNALSSGNIKELREARERCGEQLQEDLLHLLETSRGATATVLFVDPHTKQQVSCSLHPFILTASNSFFKDLLRPLLTGEKMAFQMGSVSAKLCAAGRYAASKSRRGIVVGPVPMPYLAVQPVLCFLYTRQLQIPRESVFATMLGSRLLDVAPLQAYCETILAREEVNYDTALHFFSLAGRYQAPLLQEIALLTAVMGYGVIRPTMRTVDLSEEEVKEIAAVAEELGTDTWVPPPQTSTVAKTREEYQARWDASLP
Protein: RNA replication protein (EC 2.7.7.48) (EC 3.6.4.13) (Q8UZ48)
Organism: Bamboo mosaic virus
Interaction partners:
Sequence:
MALVSKVFDSITDPSLRAVLQEEAHSQVKQVLKDTALYSRYALLPTAANTLERYAIPHNPFSTKLHTHAAAKALENDLYRTASYLLPKERVSFLFMKPSKMQYFRRRGDVDTFINADIVAKDLARYPLETIYPRLPEITTKMAFIGDSLHYFQPEVLEHIFASSPQLETLLATIVLPPEATLRLKSLYPEIYTLHYMPQKFLYKPGGLSGGEYEHDYKDLTWLKIGHVTTASMCLTVDRVESKAANHLLLIRRGRLKLSTYRSYDTPEPLVVVPKIFLPPKYNAQKPITKTKANSWILYVKSAGEPKIRDVWAKLRQTIANSELNQYEPAELLLLTNYFYVLGKLDSITSFETLLGDNILKRLFRPAIAKIQELRHWVSGPTAFMQLYKALQLVDVDFTFEVTKNWETKQENHHEPELPKDAIDMLVQSLIGINYTDAATAEATSPNQQASESKPQSDLPQPLQQTKCPEDAEAPAPLECKTAETAQEACKAGPSSNPTLNTSQEAPPSELKNSEERTCPTLRELPWKAWLKLLRGLGFQGDLEQLDIEGDPIYPIKHIRHLPVEEFNSPITATLRKMNRMPCKYSPDIERAAAFARDVMSNKTGAILPKQSHEWKTTLKRKCKLAPRQTLISVIHGAGGSGKSRALQEYMRNNKEDPIVTILPTNELRADWKAKLPAHDPDMFMTFENALLIPKGNVVIMDDYTKLPRGYIEAYVQNSPMLDLLILTGDPRQSEHFESVEGNTINDLSPSPVVFSAYARYYINATHRNNQDLANALGVYSEKQGKTRISVSNHIEDGRHTLVPSQIKQRNYVSMGRKTSTYAGCQGITASRVQVIIDNDTAKCSHQVLYTAFSRAADEIHFCNTMTDEKQFWAKVKCTPYLQAILNLTKEHSLPDPKPEPDEPLEPKAPVTHIAVENVVPLVEEITEPLPEKHDREIYSESTGHSNCIQTENEFIQAFQHQQAKDETLFWATIEKRIVTSTPESNWTEFKTKKPLGDILWLAYKEAMCLPAEPIKFDPDLWWKCADEVQNKYLQKPLHMIKNGILRQSPDFGERHIALFLKSQWVKKNEKIGTVNVKAGQTIAAFYQSTVMIFGTMARYMRLVREKFCPKNILINCEIDQPTASKWVDTHWKFDRLAYTNDFEAYDQSQDGAMLQFEVMKARHHDLPADLIESYIELKLNAKIFLGTLGIMRLTGEGPTFDANTECNIAYTHARFHIPRGTAQLYAGDDCALNCEPKERESFKPLRAQFTLKSKPVTIRQGKGSWPEFCGNIITPYGYLKHPRKTWAALHKAKLQGKNELKKTATAYALDVLPTYELGDAIHDIFTDNELTFHYQTIRTLHTEAHTRVFTNHDAIFGEEGLFSS