wanglab/gogpt-training-data huggingface dataset:
Protein: SPS-sensor serine protease component SSY5 (Endoprotease SSY5) (P47002)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11154269}; Peripheral membrane protein {ECO:0000269|PubMed:11154269}; Cytoplasmic side {ECO:0000269|PubMed:11154269}.
Interaction partners:
- SPS-sensor component PTR3
- SPS-sensor component SSY1
- Transcription factor STP1
- Transcription factor STP2
- General amino acid permease AGP1
- ERAD-associated E3 ubiquitin-protein ligase ASI1
- SCF E3 ubiquitin ligase complex F-box protein GRR1
- General amino-acid permease GAP1
- High-affinity glutamine permease
- Protein ASI2
Sequence:
MVRFFGLNKKKNEEKENTDLPADNEQNAAETSSSNVSGNEERIDPNSHDTNPENANNDDASTTFGSSIQSSSIFSRGRMTYGTGASSSMATSEMRSHSSGHSGSKNSKNLQGFKDVGKPLRAVSFLSPVKEEESQDTQNTLDVSSSTSSTLATSENARENSFTSRRSITLEYIHKSLSELEENLVDIMDDIHQDVISISKAVIEAIEYFKEFLPTTRDRIPYRISLEKSSSLRKINKIVLHFLDNLLVSDAFSNSRSILLRRFYFFLKKLNLITDDDLISESGVLPCLSVFCIGSHCNLPSMDKLGMILDELTKMDSSIISDQEGAFIAPILRGITPKSSILTIMFGLPNLQHEHYEMIKVLYSLFPDVHMYCVKDYIKKAASAVGSIPSHTAATIDTIAPTKFQFSPPYAVSENPLELPISMSLSTETSAKITGTLGGYLFPQTGSDKKFSQFASCSFAITCAHVVLSEKQDYPNVMVPSNVLQTSYKKVLTKESDRYPDGSVEKTAFLEEVQRIDQNLNWQKSNKFGQVVWGERAIVDHRLSDFAIIKVNSSFKCQNTLGNGLKSFPDPTLRFQNLHVKRKIFKMKPGMKVFKIGASTGYTSGELNSTKLVYWADGKLQSSEFVVASPTPLFASAGDSGAWILTKLEDRLGLGLVGMLHSYDGEQRQFGLFTPIGDILERLHAVTKIQWDIDPQLDG
Protein: Protein transport protein SEC24 B (Lst1-homolog protein A) (AtLst1A) (Protein of the clone eighty-four) (Q9M291)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the coat protein complex II (COPII), that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII is composed of at least five proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:O95486}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95486}; Cytoplasmic side {ECO:0000250|UniProtKB:O95486}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O95486}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95486}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O95486}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95486}.
Interaction partners:
- Protein transport protein SEC13 homolog B
- Protein transport protein SEC23
- Protein transport protein SEC13 homolog A
- Protein transport protein SEC23 B
- Protein transport protein SEC24 A
- Protein transport protein SEC23
- Protein transport protein SEC23 C
- Protein transport protein SEC31 homolog A
- Protein transport protein SEC31 homolog B
- Protein transport protein SEC23 D
Sequence:
MAAPVPPGAYRPNNNQQNSGGPPNFVPGSQGNPNSLAANMQNLNINRPPPPMPGSGPRPSPPFGQSPQSFPQQQQQQPRPSPMARPGPPPPAAMARPGGPPQVSQPGGFPPVGRPVAPPSNQPPFGGRPSTGPLVGGGSSFPQPGGFPASGPPGGVPSGPPSGARPIGFGSPPPMGPGMSMPPPSGMPGGPLSNGPPPSGMHGGHLSNGPPPSGMPGGPLSNGPPPPMMGPGAFPRGSQFTSGPMMAPPPPYGQPPNAGPFTGNSPLSSPPAHSIPPPTNFPGVPYGRPPMPGGFPYGAPPQQLPSAPGTPGSIYGMGPMQNQSMTSVSSPSKIDLNQIPRPGSSSSPIVYETRVENKANPPPPTTVDYITRDTGNSSPRYMRCTINQIPCTVDLLSTSGMQLALIVQPMALSHPSEEPIQVVDFGESGPVRCSRCKGYVNPFMKFIDQGRKFICNLCGYTDETPRDYQCNLGPDGRRRDADERPELCRGTVDFVATKEYMVRDPMPAVYFFLIDVSMNAIQTGATAAACSAIQQVLSDLPEGPRTFVGIATFDSTIHFYNLKRALQQPLMLIVPDVQDVYTPLETDVIVQLSECRQHLEILLESIPTMFQESKSPESAFGAAVKAAFLAMKSTGGKLMVFQSVLPSVGIGALSSREADGRANASAGEKEAHKLLQPADKTLRTMAIEFAEYQVCVDLFITTQAYVDMASISEIPRTTGGQVYCYYPFSALSDPPKLYNDLRWNITRPQGFEAVMRVRCSQGIQVQEYSGNFCKRIPTDIDLPAIDCDKAIMVTLKHDDKLQDGAECGFQCALLYTTISGERRIRVLNLSIPCTNMLSNLFRSADLDSQFACMLKQAANEIPSKALPLVKEQATNDCITILHSYRKFCATVTSTGQLILPEALKLLPLYTLALTKGVGLRMDGRIDDRSFWINHVSSLSTPLAIPLVYPRMIAVHDLDANDNEENVVPCPIPLQSEHLSDEGVYFLENGEDGLIYIGESVNSDILQKLFNVRSAAELPSQYVLQKYDNQLSKKFNDVVNEIRRQRSSYLRIKLCKKGDPAGNMLFQSYMVEDRGSGGASYVDFLVSVHRQIQHKLN
Protein: Rho GTPase activating protein at 19D, isoform A (Q9VRA6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLQNSNGAAAAHSAASAVATPAAAASAAAAAAAAAVAAAANNAALAASSIQPKLIVIRRRPNQGFGFTLRHFIAYPPEDDQASSSASGLVSGSATAATAASVSTNWPQEASSAAGSNSGSSSSVGVAGITGLEPTSPTSLPPYQVKAMETIFIKEVQANGPAHYANLQTGDRVLMVNNQPIAGIAYSTIVSMIKQTPAVLTLHVVPKECDVLQMHYTSIAHTPESNRLTMSTHSPSLLANGSHKTTFPAAAAVAAPPHQHQQQQQQLISYPAVAAVTTSTPAGSPQSQSQSQSHSHPNTHHAPSLHGGSRSGSITSTASGGITVLSQPFYPQQQQQQQQQQQHRHPALTGGSSSIDFGDMAHGLRQHQQQQQHLYQQQQQHHQFMRANQPPNLTVLSASSATNTPTPTARQPKSATSHNQALYAVGAGPSSAAGSGSGSLSGGSENSDLMIRLRESIKQKEEFLKSPVPASMSSASSINGNQAQSSSPAQQQHLQQHQQHFFPSHTPPGGVQVVVPPPRSRHQVMLKQQQQQQQQHQQHHVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQHHLYHQQQHQQLQQTQHRQVMINNNAKYAKDLDYFETLQETGVTNKVFERKLVSHMSKGFDPFKPLSINTSALESSASTSSTSATTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELHKATLANATIDPVPVGSSTAAIVDSASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRMSEYRSWRQVKLEIKGDLLRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEVSGGTAAVSAAQPQQQTQEDQTSMLLHNLSKIERITERETTRTSRFMPQLRRKTHGKRSAVNSDTYSGESVLVSGSSSNTTTTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSICDQALILLLPTPVSSVSLPFQSLDYAKASASASASASSTASTSSSSTLHSGGKASASSSSSSTTKFSSSSSSACSTTAVAISSSISATSSKLLSANFKKRSTGGFLGSRSSHQTRKASLDEKDSGQSSGSLGHSLGVGINLAKEQQRSSVDISILLTDDDSSSRLSDTGSMSLTTITDTLDSKLRNLRSGSESNDENGSPEFPKNRRHTLGQPLHMHSENIPYADESPERLFHQFCNPLETAPLSLHLSRSCTATNTIGGDEKPSKQSGGVAPLPPSLLKAAHKLQHSATVPIHQGSSTAPTSGAATPVGTPTGSGGAGAIPSRSSSSSVTTLTKSIQPRFSNYLSYERGNAAAGGAERVVGSAGGAASDDDSEGSTTSDPKEKLLLGERPSPSFFIERYNKKRRDHRLFRSASFNCRNYSTRHITAQTSGGVAAGVSGGVAGAVAVGVACCQALSTTGLTKDEKTDMNLTKKRQIQNKQNRSIKRRHTVGGPHDYSASNGGCSNHSHGHDLAAINYNHHNRHHQQQLLKLGSATSGGGGSGAAAAETTTTTTTTTTVLRRLGTGQAGAEASVALPASSSGSSSNNNNSPQSDGSNGNGGGVAGVASNAPPTGVGVGGNNSSGSSSNSSSTSTTPAGNGDQVLEVGIRIKNISRGRF
Protein: Hyaluronidase PH-20 (Hyal-PH20) (EC 3.2.1.35) (Hyaluronoglucosaminidase PH-20) (Sperm adhesion molecule 1) (Sperm surface protein PH-20) (P38568)
Organism: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Function: Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Alpha-L-iduronidase
- Arylsulfatase B
- Beta-glucuronidase
- Beta-glucuronidase
- Intersectin 2
- Intersectin 1.
- Cyclin-G-associated kinase
Sequence:
MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPIIPNVPFLWAWNAPSEFCLGKFNEPLDMSLFTLMGSPRINVTGQGVTIFYVDRLGYYPYIDLTTGVTVHGGIPQKVSLQDHLDKSKQDILFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLPQATDKAKQEFEKAGKDFMLETIKLGRSLRPNHLWGYYLFPDCYNHHYRKPGYNGSCFDVEIKRNDDLSWLWNESTALYPSIYLNTQQSVVVATLYVRNRVREAIRVSKIPDAKNPLPVFVYARLVFTDQVLKFLSREELVSTLGETVALGASGIVIWGSLSITRSMKSCLLLDTYMETILNPYIINVTLAAKMCSQVLCQEQGVCIRKDWNSSDYLHLNPDNFDIRLEKGGKFTVHGKPTVEDLEEFSEKFYCSCYTNLSCKEKADVKDTDAVDVCIADGVCIDASLKPPVETEGSPPIFYNTSSSTVSTTMFIVNILFLIISSVASL
Protein: Neuromodulin (Axonal membrane protein GAP-43) (Calmodulin-binding protein P-57) (Growth-associated protein 43) (P06836)
Organism: Bos taurus (Bovine)
Function: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}; Cytoplasmic side {ECO:0000250|UniProtKB:P17677}. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}; Cytoplasmic side {ECO:0000250|UniProtKB:P17677}. Synapse {ECO:0000250|UniProtKB:P17677}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}. Perikaryon {ECO:0000250|UniProtKB:P07936}. Cell projection, dendrite {ECO:0000250|UniProtKB:P07936}. Cell projection, axon {ECO:0000250|UniProtKB:P07936}. Cytoplasm {ECO:0000250|UniProtKB:P07936}. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. {ECO:0000250|UniProtKB:P17677}.
Interaction partners:
- Synapsin-1
- Beta-nerve growth factor
- palmitoyl-protein hydrolase
- Microtubule-associated protein
- Synaptophysin
- Tyrosine 3-monooxygenase
- Glial fibrillary acidic protein
- Neurotrophic factor BDNF precursor form
- Calmodulin
- Myelin basic protein
Sequence:
MLCCMRRTKQVEKNDEDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKGDAPAAEAEANEKDEAAVAEGTEKKEGEGSTPAEAAPGAGPKPEEKTGKAGETPSEEKKGEGAPDAATEQAAPQAPAPSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATAPAAEDAAAMATAQPPTETAESSQAEEKIEAVDETKPKDSARQDEGKGEEREADQEHA
Protein: Prohibitin (A8DYI7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273, ECO:0000256|RuleBase:RU366048}.
Interaction partners:
Sequence:
MAQSKLNDLAGKLGKGGPPGLGIGLKVLAAVGAAAYGVSQSLYTVEGGHRAIIFSRLGGIQSDIYSEGLHVRIPWFQYPIIYDIRSRPRKISSPTGSKDLQMINISLRVLSRPDSLNLPYLHKQLGVDYDEKVLPSICNEVLKSVIAKFNASQLITQRQQVSLLIRKELVERARDFNIILDDVSLTELSFGKEYTAAIEAKQVAQQEAQRAVFFVERAKQEKQQKIVQAEGEAEAAKMLGLAVKQNPAYLKLRKLRAAQSIARTIASSQNKVYLSADSLMLNIQDSGFDDMTEKVYKIADDLD
Protein: Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)] (P16882)
Organism: Mus musculus (Mouse)
Function: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P10912}; Single-pass type I membrane protein {ECO:0000255}. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. {ECO:0000250|UniProtKB:P19941}.; SUBCELLULAR LOCATION: [Growth hormone-binding protein]: Secreted {ECO:0000250|UniProtKB:P10912}. Note=Complexed to a substantial fraction of circulating GH. {ECO:0000250|UniProtKB:P10912}.
Interaction partners:
- Tyrosine-protein kinase JAK2
- Somatotropin
- Suppressor of cytokine signaling 2
- Signal transducer and activator of transcription
- Prolactin
- Prolactin-6A1
- Prolactin-5A1
- Insulin-like growth factor 1
- Signal transducer and activator of transcription 5B
- Tyrosine-protein kinase JAK3
Sequence:
MDLCQVFLTLALAVTSSTFSGSEATPATLGKASPVLQRINPSLGTSSSGKPRFTKCRSPELETFSCYWTEGDNPDLKTPGSIQLYYAKRESQRQAARIAHEWTQEWKECPDYVSAGKNSCYFNSSYTSIWIPYCIKLTTNGDLLDQKCFTVDEIVQPDPPIGLNWTLLNISLTGIRGDIQVSWQPPPNADVLKGWIILEYEIQYKEVNESKWKVMGPIWLTYCPVYSLRMDKEHEVRVRSRQRSFEKYSEFSEVLRVIFPQTNILEACEEDIQFPWFLIIIFGIFGVAVMLFVVIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILGIHDNYKPDFYNDDSWVEFIELDIDEADVDEKTEGSDTDRLLSNDHEKSAGILGAKDDDSGRTSCYDPDILDTDFHTSDMCDGTLKFRQSQKLNMEADLLCLDQKNLKNLPYDASLGSLHPSITQTVEENKPQPLLSSETEATHQLASTPMSNPTSLANIDFYAQVSDITPAGGDVLSPGQKIKAGIAQGNTQREVATPCQENYSMNSAYFCESDAKKCIAVARRMEATSCIKPSFNQEDIYITTESLTTTAQMSETADIAPDAEMSVPDYTTVHTVQSPRGLILNATALPLPDKKNFPSSCGYVSTDQLNKIMQ
Protein: tRNAHis guanylyltransferase catalytic domain-containing protein (Q54WD4)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MNGTLFLKNCLNQININTKLQQRQILNKLITYINQNKNNSINLRYFTNIKNFNNNTNNKVNSSPPQKQQQQQQQQQQQQQQQQQQQQKQQKQQQQQKQQKINNNNKMNDPFSALGDRMKSYEDGMKITIEKNNSFIIRLDGHSFSKFSKVFKKPGIAWDIRIHQAMVETATALMKTFLPTVVYTFSDEITMCFPSIDKEAIDDGEIPQLAYNGKVQKLISLTAGLASTVFYKSITQALYDTDKEEKIIDLLKTATPSFDSRLFVLPSNDEIRHNLIWRSIIDCKRNSVSQVGQSHFLPKQIHGLSGQEIKKKLLLEKGIDFNDEPDWYKYGVYLKKQNYTHKGFSPIKPTQEITVLRNKVVPFSFDITKLSNSNDFITKKILDEDFKLEFNSNPLSLSNSTGSTSSNSSSEGSLI
Protein: Probable HTH-type transcriptional regulator YhaJ (P67660)
Organism: Escherichia coli (strain K12)
Function: Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity).
Interaction partners:
- Pirin-like protein YhaK
- Inner membrane protein YqjF
- Probable serine transporter
- Quercetin 2,3-dioxygenase
Sequence:
MAKERALTLEALRVMDAIDRRGSFAAAADELGRVPSALSYTMQKLEEELDVVLFDRSGHRTKFTNVGRMLLERGRVLLEAADKLTTDAEALARGWETHLTIVTEALVPTPAFFPLIDKLAAKANTQLAIITEVLAGAWERLEQGRADIVIAPDMHFRSSSEINSRKLYTLMNVYVAAPDHPIHQEPEPLSEVTRVKYRGIAVADTARERPVLTVQLLDKQPRLTVSTIEDKRQALLAGLGVATMPYPMVEKDIAEGRLRVVSPESTSEIDIIMAWRRDSMGEAKSWCLREIPKLFNGK
Protein: Cytokinin-beta-glucosidase (EC 3.2.1.-) (Protein ROL C) (trolC) (Q43592)
Organism: Nicotiana tabacum (Common tobacco)
Function: Hydrolyzes cytokinin glucosides thus liberating free cytokinins.
Interaction partners:
Sequence:
MAEDNLCALFFKLTVQGVTCSDGLKKHMENAEDELKPLLEHGPQGESMDIDEEEVSGAKRLLYLYVDCPTMMRCFFGRSMPYNCRGGTLLTDLPPYHADASPHEVSRGLGKATDFFSYEDAIRSAYFAAFSFSGPVRKLDQQLELTSTRGEPLTFSLYARSPGRLEPGELVRHGECKFAG
Protein: Transcription antitermination protein NusB (Antitermination factor NusB) (N utilization substance protein B) (P0A780)
Organism: Escherichia coli (strain K12)
Function: Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP). It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis. Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. The affinity of NusB for the boxA RNA sequence is significantly increased in the presence of the ribosomal protein S10. NusB may serve as a loading factor that ensures efficient entry of S10 into the transcription complexes. It also modulates the rrn boxA-mediated transcription elongation rates.
Interaction partners:
- Transcription termination/antitermination protein NusG
- Small ribosomal subunit protein uS10
- 6,7-dimethyl-8-ribityllumazine synthase
- Transcription termination/antitermination protein NusA
- Nus factor SuhB
- DNA-directed RNA polymerase subunit omega
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta
- Riboflavin biosynthesis protein RibD
- DNA-directed RNA polymerase subunit beta'
Sequence:
MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLAGVATNTAYLDGLMKPYLSRLLEELGQVEKAVLRIALYELSKRSDVPYKVAINEAIELAKSFGAEDSHKFVNGVLDKAAPVIRPNKK
Protein: T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) (B2RWW0)
Organism: Mus musculus (Mouse)
Function: May function as a GTPase-activating protein. May play a role in transmission ratio distortion (TRD) in mouse, in which heterozygous males for t-locus transmit their t-carrying chromosome to 95% or more of their offspring.
Interaction partners:
Sequence:
MKLISSLDGSKTLNANNMETLIECQSEGDIKVPPLLTSCESEDSICQLTEIKKRKKVLSWPSLMRKLSPSSDFSGSLEPELKVSLFDQPLSIICGENDTLPRPIQDILTILCLKGPSTEGIFRKAASEKARKELKEGLNCGVSVNLKQLPVHLLAVVFKDFLRGIPLKLLSCDLFEDWMGALEKPTEEDRIEALKQVAGGLPRPNLLLLRHLLYVLHLISKNAEVNKMDSSNLAICIGPNMLTLKNDQSLSFQAQKDLNNKVKILVEFLIDNCFEIFGENIRTRSRITSDDSLEHTDSSDVSTLQNDSAYDSNDPDVEPTSGAASPNRQLEGPTPTMAGLDTRGQRDTCESSSESSVSMVVRLKSSIVQQDRRFSEPNMSPSRECLVGPTSKQKLARSEDSFTLSQDASCSEGDEAEDPFTEEVFPAVDSKPKRPVDLKIKNWTQGLASPQGHITKAFSRSSPGESLGSSPVPSPSCPKRNFFTRHQSFTTKTDKTKPQREIRKHSMSFSFASHKKVLPRTSSIGSEKSKDFSRDQLQKDLRKESQLSGRIVQENESEIQSQTSLGFSLSGTWALSVDNTFQLVDMRKPGSPPSYEEAIYYQTSGLTAYGGQTVGSMRSRMFKPSTAVPPVPSHHGGDLSEGTPGGHRLSSVTEHWTHSQTVHVSIETQGRSELHQLRTVSESMQKAKLDCLGPQHSHLVFEADQLCCARESYI
Protein: DNA repair protein rhp55 (RAD55 homolog) (O14129)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for radiation resistance and meiotic viability and acts in recombination and recombinational DNA repair pathways.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA repair protein rhp57
- Swi5-dependent recombination DNA repair protein 1
- DNA repair protein rhp54
- DNA repair and recombination protein rad22
- Mating-type switching protein swi5
- ATP-dependent DNA helicase srs2
- DNA repair protein rhp51
- ATP-dependent DNA helicase hus2/rqh1
- Meiotic recombination protein dmc1
- Meiotic recombination protein rdh54
Sequence:
MLSSQHRLVTQPAIRAYEAFSAPGFGFNSKLLDDAFGGSGLKRGYISEVCGAPGMGKTSLALQITANALLSGSRVIWVETCQPIPMERLRQLLDNHVPSSQDEEEKCDTDELLNLLDVVYAPNLVNILAFLRNFDQEKHLKEIGLLIIDNLSMPIQLAYPTSPEDYAYLRLRRNTSKKSSLSDSSQKENTLTLNKENEFSSKDDSNFAFHNSSTKTTINRRKKAIGTISSLLSKITSSCYVAIFVTTQMTSKVVSGIGAKLIPLLSTNWLDNLSYRLILYSRHSTEESKDGQSRPSHQLLRYAFMAKQPPAHSAESELAFQLTSTGIQDYQSIPTNSSQRRKRSILECES
Protein: Elongation initiation factor 2 alpha subunit, putative (Q57ZM2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Translation initiation factor, putative
- Eukaryotic translation initiation factor 3 subunit 7-like protein
- Eukaryotic translation initiation factor 3 subunit 8, putative
- Eukaryotic translation initiation factor 3 subunit A
- Translation initiation factor eIF2B subunit beta
- Eukaryotic translation initiation factor 3 subunit E
- Small ribosomal subunit protein uS5
- RNA-binding protein, putative
- 40S ribosomal protein S15, putative
- Translation initiation factor eIF2B subunit gamma
Sequence:
MAAYGIVESPDNVDYKTKCCCQTTDGVYFQVPKEYFRLHANLSRRKLLIAEPFGVPLDSSAFESLVVLLEKAAIVSPAAATAGTEVVSKGDGAKQQWIKDLNKRQQKFVGACLGVTTWDGADVYFYEEKLPKESDVVWVKVIQVNDTSAVVQLLEYGNHEGIIPYTEITRIRIRAIGKVIKVGKNEAAQVIRIDKDKGYIDLSKKQVTLKEAKDCEARFFKGNEVRSVVCHVADECGVPPAEAMKRIAYPLYRRQPGKHAWEWLYELNQTKDVKGILGDLEISEAEIKVLMTTLEHTMRTEIATIHADIEMTCFQCDGVNALREVLLVGRDFKAGKDPLIPISVTIVGPPKYRLRAKTELKEEGIVRMKEAIEMMKIEMAKRGGILKVVAGPFVLGEEEHTKEERNEDAEDDEGEDTD
Protein: Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (GLM-R) (mGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (Novel cytokine receptor 10) (NR10) (ZcytoR17) (Q8K5B1)
Organism: Mus musculus (Mouse)
Function: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25847241}; Single-pass type I membrane protein {ECO:0000305}. Presynaptic cell membrane {ECO:0000269|PubMed:25381841}. Cell projection, axon {ECO:0000269|PubMed:25381841}.
Interaction partners:
- Interleukin-31
- Oncostatin-M-specific receptor subunit beta
- Tyrosine-protein kinase JAK1
- Oncostatin-M
Sequence:
MWTLALWAFSFLCKFSLAVLPTKPENISCVFYFDRNLTCTWRPEKETNDTSYIVTLTYSYGKSNYSDNATEASYSFPRSCAMPPDICSVEVQAQNGDGKVKSDITYWHLISIAKTEPPIILSVNPICNRMFQIQWKPREKTRGFPLVCMLRFRTVNSSHWTEVNFENCKQVCNLTGLQAFTEYVLALRFRFNDSRYWSKWSKEETRVTMEEVPHVLDLWRILEPADMNGDRKVRLLWKKARGAPVLEKTFGYHIQYFAENSTNLTEINNITTQQYELLLMSQAHSVSVTSFNSLGKSQEAILRIPDVHEKTFQYIKSMKAYIAEPLLVVNWQSSIPAVDTWIVEWLPEAAMSKFPALSWESVSQVTNWTIEQDKLKPFTCYNISVYPVLGHRVGEPYSIQAYAKEGTPLKGPETRVENIGLRTATITWKEIPKSARNGFINNYTVFYQAEGGKELSKTVNSHALQCDLESLTRRTSYTVWVMASTRAGGTNGVRINFKTLSISVFEIVLLTSLVGGGLLLLSIKTVTFGLRKPNRLTPLCCPDVPNPAESSLATWLGDGFKKSNMKETGNSGDTEDVVLKPCPVPADLIDKLVVNFENFLEVVLTEEAGKGQASILGGEANEYVTSPSRPDGPPGKSFKEPSVLTEVASEDSHSTCSRMADEAYSELARQPSSSCQSPGLSPPREDQAQNPYLKNSVTTREFLVHENIPEHSKGEV
Protein: Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) (O75005)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative leucine--tRNA ligase, cytoplasmic
- Putative glycine--tRNA ligase
- Probable arginine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, cytoplasmic
- Probable cysteine--tRNA ligase
- Lysine--tRNA ligase, mitochondrial
- Tyrosine--tRNA ligase, mitochondrial
- Probable proline--tRNA ligase, mitochondrial
- Elongation factor 1-gamma
- Histidine--tRNA ligase, mitochondrial
Sequence:
MADKGCEAAQSKDSSAPGSGEPRPKTEKELERERQKAAKLEKYHAKLAAKKAKEEARKPKLDKKAKIASPVAEYVEKTTPGEKKVLQDLDSPALKSYNPKAVESAWYDWWVKSGFFEPEFGPDGKPKKEGVFVITSPPPNVTGALHIGHALTIAIQDSLARWNRMLGKTVLFLGGFDHAGLSTQSVVEKKLWYTQKKTRHDYPRDKFVDIVWEWKEEYHNRIKNQMSRLGGSFDWTREAFTMDENLSRAVVETFVRLHEENIIYRANRLVNWCTALQTTLSNLEVENVDVPGRTLLKVPGYDEPVEVGVLTSIAYAVEGSDERIVIATTRPETLLGDTAVAVHPQDPRYKHLHGKFVKHPFCNRSIPIICDDIIVDMEFGTGAVKITPAHDPNDYEVGKRHNLEFINIFTDDGLLNENCGEFAGMKRFTARVKVVERLKELGLFVGTKENPMVIPLCGKTSDIIEPVMKPQWWVNQKEMAAAAAEVVKSGEIEIAPDMSRREFIRWMENIQDWCISRQLWWGHRIPAYFVNLADEPSQDRSEGRYWVTGRTLEQAEEKAKAAFPGKSFTLEQDEDVLDTWFSSGLWPFSTLGWPKDTSDYENFYPTTLMETGWDILFFWIARMVMLGLKLTGKIPFKRVFCHALVRDAQGRKMSKSLGNVVDPIDVIEGISLQALHDKLLVGNLDSREVEKAKKGQRLSYPKGIPQCGTDALRFTLCSLTTGGRDLNLDILRVEGYRKFCNKLYNATKFALGRLGSNFVPNKTADLTGNESLVEKWIFHRLNIAAAAMNKNMEEMNFLQATSAVHQFWLYELCDVYIENSKYLLSDGTEVQQESAKQTLYTVLDNALRLMHPFMPYVTEEMWQRLPRRPGDKTQTIVKAAFPVERVDYSNEIAAKYYESIITVVHSTRSMMAENGIKSDAVVYIHPDEEHSKLITSESASIQSLIKKCKTLSIVDNTFDSDKCVKNEVLEGSTIFLERNN
Protein: phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (F1LQJ7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Pyruvate carboxylase, mitochondrial
Sequence:
TLLPSPPSLTPRLHWFLWPSRSASPGAMAAMYLPGLRLSWHRLRPWCRSPCRSIQTLRVLSGDLSQLPAGVRDFVERSAHLCQPAGIHICDGTEAENAATLALLEEQGLIRKLPKYENCWLARTDPKDVARVESKTVIVTSSQRDTVPLLAGGASGQLGNWMSPDEFQRAVDQRFPGCMQGRTMYVLPFSMGPLGSPLSRIGVQLTDSPYVVASMRIMTRLGTHVLQALGDGDFIKCLHSVGQPLTGHGDPVGRWPCNPEKTLIGHVPEQREIVSFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITNPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGQLRAINPENGFFGVAPGTSATTNPNAMATIQSNTVFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHPNSRFCVPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFSWRHGVFVGSAMRSESTAAAEHKGKTIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGARLPRIFHVNWFRRDEAGRFLWPGFGENARVLDWICRRLGGEDSARETPIGLVPKEGALDLSGLRAIDTSQLFSIPKDFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALEERVQKM
Protein: Cathelin-related peptide SC5 (Antibacterial peptide SMAP-29) (Myeloid antibacterial peptide MAP-29) (P49928)
Organism: Ovis aries (Sheep)
Function: Broad spectrum bactericidal agent.
Subcellular location: Secreted.
Interaction partners:
Sequence:
METQRASLSLGRCSLWLLLLGLALPSASAQVLSYREAVLRAADQLNEKSSEANLYRLLELDPPPKQDDENSNIPKPVSFRVKETVCPRTSQQPAEQCDFKENGLLKECVGTVTLDQVRNNFDITCAEPQSVRGLRRLGRKIAHGVKKYGPTVLRIIRIAG