wanglab/gogpt-training-data huggingface dataset:
Protein: Aquaporin-7 (AQP-7) (Aquaglyceroporin-7) (O54794)
Organism: Mus musculus (Mouse)
Function: Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea (By similarity). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15746100, ECO:0000269|PubMed:17077387, ECO:0000269|PubMed:25643985}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:25643985}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Lipid droplet {ECO:0000269|PubMed:25643985}. Note=Internalized from the cell membrane in response to catecholamine-induced activation of PKA; detected on intracellular membranes and colocalizes with lipid droplets (PubMed:25643985). Colocalizes with PLIN1 in adipocytes, probably on lipid droplets (By similarity). {ECO:0000250|UniProtKB:O14520, ECO:0000269|PubMed:25643985}.
Interaction partners:
- Aquaporin-8
- Aquaporin-11
- Aquaporin-12
- Aquaporin-4
- Aquaporin-5
- Glycerol kinase
- Aquaporin-1
- Lens fiber major intrinsic protein
- glycerol kinase
- Aquaporin-2
Sequence:
MAPRSVLETIQSVLQKNMVREFLAEFLSTYVMMVFGLGSVAHMVLGENSGSYLGVNLGFGFGVTMGVHVAGGISGAHMNAAVTFTNCALGRMTWKKFPVYVLGQFLGSFSAAATTYLIFYGAINHFAGGDLLVTGSKATANIFATYLPEYMTLWRGFLDEAFVTGMLQLCLFAITDKKNSPALQGTEPLVIGILVTVLGVSLGMNSGYAINPSRDLPPRLFTFIAGWGKQVFRAGNNWWWVPVVAPLLGAYLGGIVYLGLIHPSIPQDPQRLENFTARDQKVTASYKNAASANISGSVPLEHF
Protein: Isoniazid-induced protein IniC (P9WJ95)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Isoniazid-induced protein IniA
- Isoniazid-induced protein IniB
- Small ribosomal subunit protein bS6
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS9
- Possible transcriptional regulatory protein
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS15
Sequence:
MSTSDRVRAILHATIQAYRGAPAYRQRGDVFCQLDRIGARLAEPLRIALAGTLKAGKSTLVNALVGDDIAPTDATEATRIVTWFRHGPTPRVTANHRGGRRANVPITRRGGLSFDLRRINPAELIDLEVEWPAEELIDATIVDTPGTSSLACDASERTLRLLVPADGVPRVDAVVFLLRTLNAADVALLKQIGGLVGGSVGALGIIGVASRADEIGAGRIDAMLSANDVAKRFTRELNQMGICQAVVPVSGLLALTARTLRQTEFIALRKLAGAERTELNRALLSVDRFVRRDSPLPVDAGIRAQLLERFGMFGIRMSIAVLAAGVTDSTGLAAELLERSGLVALRNVIDQQFAQRSDMLKAHTALVSLRRFVQTHPVPATPYVIADIDPLLADTHAFEELRMLSLLPSRATTLNDDEIASLRRIIGGSGTSAAARLGLDPANSREAPRAALAAAQHWRRRAAHPLNDPFTTRACRAAVRSAEAMVAEFSARR
Protein: Protein SEC13 homolog (CeSEH13R) (GATOR complex protein SEC13) (Nuclear pore complex protein 20) (Q9N4A7)
Organism: Caenorhabditis elegans
Function: Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:P55735}; Peripheral membrane protein {ECO:0000250|UniProtKB:P55735}; Cytoplasmic side {ECO:0000250|UniProtKB:P55735}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21478858}; Peripheral membrane protein {ECO:0000250|UniProtKB:P55735}; Cytoplasmic side {ECO:0000250|UniProtKB:P55735}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:21478858}. Lysosome membrane {ECO:0000250|UniProtKB:P55735}. Note=Localizes close to endoplasmic reticulum exit sites (ERES) and the nuclear envelopes of proliferating germ nuclei. {ECO:0000269|PubMed:21478858}.
Interaction partners:
- Nucleoporin SEH1
- WD_REPEATS_REGION domain-containing protein
- Nuclear pore complex protein 15
- WD_REPEATS_REGION domain-containing protein
- Nuclear pore complex protein Nup98-Nup96
- Nuclear pore complex protein 5
- Nuclear pore complex protein Nup85
- Nuclear Pore complex Protein
- Nsp1_C domain-containing protein
- Yeast SEC homolog
Sequence:
MTTVRQRIDTQHRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRPNGQSYPMAELVGHSGPVWKVSWAHPKYGGLLASASYDKKVIIWNEQQGRWQKAYEWAAHEASTTCVAFAPHQYGLMLASASADGDIGILRYDNSSNEWISSKIQKCHEQGVNSVCWAPGSADPAAKKRLVSAGNDKNVKIWAFDDATNEWILEKTLAGHTDFVREAAWCPVTNNGQHTIVSCGMEGNLVLFRTSNIETEEWKAKLLETAPCALYHSSFSPCGSFLSVAGDDNVITIWRENLQGQWIKVPRDNKEREGMSQAVGAPGAQR
Protein: Mlh3 protein (Q99L38)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVYINRMTGLSTFVAPTDDLHTACTKDLTTVAVDVLLGNDAVDAAAAAVSEPLQSLFSEWSNPVFARYPEVAVDVSSGQAESLAVKIHNVLYPYRFTKEMIHSVKVLQQVDNKFIACLMSTRMDEDGRTGGNLLVLVDQHAAHERIRLEQLITDSYEKQDPQSAGRKKLLSSTIIPPLAITVSEEQRRLLRN
Protein: Fibroblast growth factor 6 (FGF-6) (Heparin secretory-transforming protein 2) (HST-2) (HSTF-2) (Heparin-binding growth factor 6) (HBGF-6) (P10767)
Organism: Homo sapiens (Human)
Function: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.
Subcellular location: Secreted, extracellular space.
Interaction partners:
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor 2
- Klotho
- Pro-epidermal growth factor
- Fibroblast growth factor receptor 3
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Fibroblast growth factor-binding protein 1
- Decorin
- Vascular endothelial growth factor receptor 2
Sequence:
MALGQKLFITMSRGAGRLQGTLWALVFLGILVGMVVPSPAGTRANNTLLDSRGWGTLLSRSRAGLAGEIAGVNWESGYLVGIKRQRRLYCNVGIGFHLQVLPDGRISGTHEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATPSFQEECKFRETLLPNNYNAYESDLYQGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI
Protein: Phospholipid-transporting ATPase accessory subunit CRF1 (CDC50/ROS3 family protein 1) (CRF1) (P53740)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Potential non-catalytic subunit for a heteromeric phospholipid translocase (PLT) CRF1-DNF3, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs CDC50-DRS2 and LEM3-DNF1/2. May be involved in transport from early endosomes to the trans-Golgi network (TGN).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:17093059}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- eIF-2-alpha kinase activator GCN1
- Probable phospholipid-transporting ATPase DNF3
- Phospholipid-transporting ATPase DNF2
- Phospholipid-transporting ATPase DNF1
- Adenine phosphoribosyltransferase 2
Sequence:
MGLILRWKEKKQLSSKQNAQKSRKPANTSFRQQRLKAWQPILSPQSVLPLLILMACVFAPIGIGLVVSTISVQRLVVNYTECDALAPAKHFETIPSEYVDYHFSKKVAVQPQWMVLTDPELGNQTCRIQFEVPNHIKKSTYVYYRLTNFNQNYREYVQSLDLDQLKGKALIGNDLDPNCDPLRTVENKTIFPCGLIANSMFNDTFGTTLTGVNDTADYLLTTKGIAWDTDSHRYGKTEYNASDIVPPPNWAKLFPNGYTDDNIPDLQNWEQFKIWMRTAALPNFYKLAMKNETNGLGKGIYIADIELNYPVRSFYGTKSFVLTTNSIIGAGNEALGIVYLIVAGIATLFAILFLIKVIFKPRPMHDHSYLNFENSDTPFDESSVVSIPLREIL
Protein: 5'-AMP-activated protein kinase subunit beta-1 (Q95SG9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDNNEEEEEAAVGAEPATGSQLTGDEDDIRKTALPTVLRWDGGGKNVTISGTFSDWKPMAMVRSHQNFVTIIDLPEGDHQYKFCVDGEWKHDPKLKSVENAEGQRNNLVSVRESDFEVFQALAKDSENVTNYAEKEYSQEVPQVKPWEKVSGPPVLPPHLLQVILNKDTPLSCEPTLLPEPNHVMLNHLYALSIKDGVMVLSATHRYRKKYVTTLLYKPI
Protein: Protein GAT3 (Q07928)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- AP-1-like transcription factor YAP5
- Uncharacterized protein YKL102C
- Putative uncharacterized protein YDR521W
- Protein ECM23
Sequence:
MNIKTLCHPEYKRISVESLLNPVEETIDCEKPHSQTKINTAKPISASLYVTTNNTAVVQHNVQKRKGVTRRCPQCAVIKTSPQWREGPDGEVTLCNACGLFYRKIFLVFGKDLAKRYFNEIKGVSVKRKVPKSLYGVTRTR
Protein: Uncharacterized protein C9orf153 (Q5TBE3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFLTGDTSPAEDNREATLPQCSLPELYACIENFNKESKKSNLLKMHGISLNEAQEVLARNLNVMSFTRGADVRGDLQPVISVNKMNKPGKHRKTPSPKINK
Protein: Sodium/hydrogen exchanger (B0QZV3)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004195}.
Interaction partners:
Sequence:
MAGARRGWRLAPVRRGVCGPRARPLMRPLWLLFAVSFFGWTGALDGSGGTTRAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFIAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPDNERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTESATASAPRRFMGNSSEDALDRELTFGDHELVIRGTRLVLPMDDSEPALNSLDDTRHSPA
Protein: Probable membrane protein (O86314)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved protein
- Possible membrane protein
- Uncharacterized protein Rv0104
- Possible membrane protein
- Conserved hypothetical membrane protein
Sequence:
MSKPFAPRRLYTPRTSRTLAPRLDPEAVGRTTESIARFFGTGRYLLVQTLLVLTWIVLNLFAVGLRWDPYPFILLNLAFSTQASYAAPLILLAQNRQEKRDRAVFEEDRRRAAQTKADTEYNARELAALRLAIGEVPTRDYLRHELDSLRALLAELQPTDPDVAQPRVADEAEQHAKKSG
Protein: Double homeobox B-like 1 (L7MUF2)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MELSCSTGLLEKEARRRRIILTQSQKDTLRVWFEKNPNPDLATRGHLAKELGISESQIMTWFQKHRKIRKQAEFAC
Protein: Slc24a4 protein (A0A8J8XAJ2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEDRFSVNSTHHVSIALMLCSDGSAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLILIILYVFYILIMKYNMKMQTFFTTKQKSIANGNPVSNELEDGNDLYDGSFDDPSVPLLGQVKEKPPYGKSPVVMVDEILSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVNSKPLQNGRHENMENGNVPVENPEDPQQGQEQQPPPQPPPPEPESVETVFLSPFSMPEAKGDKAKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMVINYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGIYVLVLYAVFLCFSIMIEFNVFTFVNLPMCREDD
Protein: Mitochondrial translation factor 2 (O14204)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Large ribosomal subunit protein bL33m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein bS21m
- Small ribosomal subunit protein mS23
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS19m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein uL23m
- Small ribosomal subunit protein bS18m
Sequence:
MRVCRTLKISIKSFPSSLSLLSLYKRRLHKSTSHSSTATSSHYSKNNLPSDSPDLLFDYFIDGHKIHVNPNAVEPLHLRRNADVVGFSLPHGVKQSFENYIQKYPLSDQVENSSNIYDPSSPPDSPRKQQTHLGTIPPEHPDVFFHNLKKKLDSLHTHSSPLTVYRNHLLTCETDSALAQLFKSEIYQQLSDFRRDFPLSHALRDTMLIARLNFLNPMLALSFFQAVKKHSPNAYVRGCSAPVYNQAILSVWQGCKDPNFVLHLLGEMRENVVMRDSETREAINIVYKDVNEWPKQLLFSQNRILEKLKIFLLP
Protein: Chromosome transmission fidelity-like protein (F4KEU4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Chromosome transmission fidelity protein 18 homolog
- Zinc ion binding protein
- Replication factor C subunit 5
- Replication factor C subunit 3
- Replication factor C subunit 2
- DNA polymerase epsilon catalytic subunit A
- DNA polymerase epsilon catalytic subunit B
- Protein STICHEL
- Protein STICHEL-like 1
- Replication factor C subunit 4
Sequence:
MEIRVKCRCGEEECSEWAIVELQGVVETQASFQGSIQNLEIGRLCHSDSSQGTYTFTVGYHELVGSKVTLKKPLLVLKKLQFDEVSGKATELEVVGIIRTKILFKTRPKPLISGNNNLSLNKLKPLYCFIISACFNNVVSVCTIE
Protein: NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) (O75113)
Organism: Homo sapiens (Human)
Function: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity. Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6A037}. Nucleus {ECO:0000250|UniProtKB:Q6A037}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q6A037}. Nucleus, PML body {ECO:0000250|UniProtKB:Q6A037}. Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated. {ECO:0000250|UniProtKB:Q6A037}.
Interaction partners:
- NF-kappa-B essential modulator
- Caspase-8
- E3 ubiquitin-protein ligase NEDD4
- Polyubiquitin-C
Sequence:
MAARAVLDEFTAPAEKAELLEQSRGRIEGLFGVSLAVLGALGAEEPLPARIWLQLCGAQEAVHSAKEYIKGICEPELEERECYPKDMHCIFVGAESLFLKSLIQDTCADLCILDIGLLGIRGSAEAVVMARSHIQQFVKLFENKENLPSSQKESEVKREFKQFVEAHADNYTMDLLILPTSLKKELLTLTQGEENLFETGDDEVIEMRDSQQTEFTQNAATGLNISRDETVLQEEARNKAGTPVSELTKQMDTVLSSSPDVLFDPINGLTPDEEALSNERICQKRRFSDSEERHTKKQFSLENVQEGEILHDAKTLAGNVIADLSDSSADSENLSPDIKETTEEMEYNILVNFFKTMGYSQEIVEKVIKVYGPSTEPLLLLEEIEKENKRFQEDREFSAGTVYPETNKTKNKGVYSSTNELTTDSTPKKTQAHTQQNMVEKFSQLPFKVEAKPCTSNCRINTFRTVPIEQKHEVWGSNQNYICNTDPETDGLSPSVASPSPKEVNFVSRGASSHQPRVPLFPENGLHQQPEPLLPNNMKSACEKRLGCCSSPHSKPNCSTLSPPMPLPQLLPSVTDARSAGPSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRTDLKHIVIDGSNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNVTEQHFLTQLQELGILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVNESVSWREIITKRLLQYTFVGDIFMVPDDPLGRSGPRLEEFLQKEVCLRDMQPLLSALPNVGMFDPSFRVPGTQAASTSHQPPTRIQGAPSSHWLPQQPHFPLLPALPSLQQNLPMPAQRSSAETNELREALLKIFPDSEQRLKIDQILVAHPYMKDLNALSAMVLD
Protein: ERO1-like protein 2 (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Q9Y7P1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly pdi1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on pdi1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between pdi1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15449306}; Peripheral membrane protein {ECO:0000269|PubMed:15449306}; Lumenal side {ECO:0000269|PubMed:15449306}.
Interaction partners:
- Putative protein disulfide-isomerase C1F5.02
- Thioredoxin domain-containing protein C13F5.05
- Uncharacterized protein C3D6.13c
- Thioredoxin domain-containing protein C959.05c
- Protein disulfide-isomerase C17H9.14c
Sequence:
MKIAKGLVGLLILYKNVCQVLCKSGSSVKSGSPWSIKNDGKSIIHDTLNSSYSDIENLNSRVSPLLFDLTEKSDYMRFYRLNLFNKECRYNLDDNVACGSSACNVLVTDEQDVPEVWSSKSLGKLEGFMPELSRQIVETDRSVMEHVDKISQSCLLERLDDEAHQYCYVDNELDSGCVYVSLLENPERFTGYSGPHSTRIWEMIYNQCLPDSSAPTIDFPALFMQGPLAPPPKPQEQLLKERMDAWTLEQRVFYRVLSGMHSSISTHLCHGYLNQRNGVWGPNLQCFQEKVLNYPERLENLYFAYALMQRAIDKLYGHLDSLTFCHDSVLQDSEVRQKIAGLVSLIHNSPKMFDETMLFAGDPSISTALKEDFREHFKTVSALMDCVGCERCRLWGKIQTNGFGTALKILFEVSNIEDEVTNFDSRSFSLRLRRSEIVALINTFDRLSRSINFVDDFKQIYSEQHKPASFKRRVLRRIKQLLFSVTPVALHPFLQKTSSILVDLYFDFKAEWDNVMLGFRYVFASYLRFPRLFKFVLFSQESPFLNWTSHHLQRYIPKNWFPEVASV
Protein: Casein kinase 1-like protein 3 (EC 2.7.11.1) (Protein CASEIN KINASE I-LIKE 3) (CK1.3) (Q93Z18)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein kinase involved in blue light responses (e.g. hypocotyl elongation and flowering) by phosphorylating CRY2 to reduce its stability.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16126836, ECO:0000269|PubMed:23897926}. Nucleus {ECO:0000269|PubMed:16126836, ECO:0000269|PubMed:23897926}. Note=Translocates mostly in nucleus upon blue light treatment, especially in nuclear bodies. {ECO:0000269|PubMed:23897926}.
Interaction partners:
- Cryptochrome-2
- At3g49990
- Leucine-rich repeat protein kinase family protein
- Serine/threonine-protein kinase MPS1
- Probable glycosyltransferase STELLO2
- Bystin
- Cyclin-dependent kinases regulatory subunit 2
- Serine/threonine-protein kinase RIO2
Sequence:
MERIIGGKYKLGRKIGGGSFGEIFLATHVDTFEIVAVKIENSKTKHPQLLYEAKLYRILEGGSGIPRIKWFGVDGTENALVMDLLGPSLEDLFVYCGRKFSPKTVLMLADQMLTRIEFVHSKGYLHRDIKPDNFLMGLGRKANQVYLIDFGLAKRYRDANTNRHIPYRENKNLTGTARYASCNTHLGIEQSRRDDLESLGYVLLYFLRGSLPWQGLKAVDKKQKYDKICEKKISTPIEVLCKNHPVEFASYFHYCHTLTFDQRPDYGFLKRLFRDLFSREGYEFDYIFDWTIIKYQQAQKSRNQSQAVPGSSNPRAMPVDTSNHRGGPNISYEAEASERVRSANAIGPSPQINNNTAAGRTPGFDHPVHKNMNMPSTSLSPAGTSKRNVGPETSNSGYGSGNRTGWTSSFMSPEK
Protein: Growth factor receptor-bound protein 14 (GRB14 adapter protein) (Q5ICW4)
Organism: Bos taurus (Bovine)
Function: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14449}. Endosome membrane {ECO:0000250|UniProtKB:Q14449}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14449}. Note=Upon insulin stimulation, translocates to the plasma membrane. {ECO:0000250|UniProtKB:Q14449}.
Interaction partners:
- Tyrosine-protein kinase receptor
Sequence:
MTTSLQDGQSAAGRAAARDSPLAAQVCGAAQGRGDARDLAPAPWLHARALLPPPDATRGCAADRRKKKDLDVLEMPSIPNPFPELCCSPFTSVLSAGLFPKANSRKKQVIKVYSEDETSRALEVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHVGLERTIEDHELVIEVLSNWGMEEENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGFLHAKEQGKKSWKKIYFLLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPTNYGFCFKPNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGYSSQSISPMRSISENSRVAMDFSGQKTRVIENPTEALSVAVEEGLAWRKKGCLRLGSHGSPTASSQSSATSMAIHRSQPWFHHKMSREEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL
Protein: Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (IRK-1) (RBL-IRK1) (Potassium channel, inwardly rectifying subfamily J member 2) (Q64273)
Organism: Rattus norvegicus (Rat)
Function: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:21209095}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:21209095}.
Interaction partners:
- Potassium voltage-gated channel subfamily KQT member 1
- ATP-sensitive inward rectifier potassium channel 12
- Inward rectifier potassium channel 4
- Potassium voltage-gated channel subfamily KQT member 3
- Potassium voltage-gated channel subfamily KQT member 4
- Potassium voltage-gated channel subfamily Q member 5
- Potassium voltage-gated channel subfamily KQT member 2
- Endothelin-1 receptor
- ATP-sensitive inward rectifier potassium channel 14
- Guanine nucleotide-binding protein G
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKESKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHCYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
Protein: Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1 homolog) (Thymic epithelial cell surface antigen) (Q8VBZ3)
Organism: Mus musculus (Mouse)
Function: Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate. Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (By similarity). May play a role in T-cell development.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305|PubMed:9828125}.
Interaction partners:
Sequence:
MAAAQEADGAGSAVVAAGGGSSGQVTSNGSIGRDTPAETQPQNPPPQPAPNAWQVIKGVLFRIFIIWAISSWFRRGPSPQDQSGPGGAPRVASRNLFPKDTLMNLHVYISEHEHFTDFNATSALFWEQHDLVYGDWTSGENSDGCYEHFAELDIPQSVQQNGSIYIHVYFTKSGFHPDPRQKALYRRLATVHMSRMINKYKRRRFQKTKNLLTGETEADPEMIKRAEDYGPVEVISHWHPNITINIVDDHTPWVKGSVPPPLDQYVKFDAVSGDYYPIIYFNDYWNLQKDYYPINESLASLPLRVSFCPLSLWRWQLYAAQSTKSPWNFLGDELYEQSDEEQDSVKVALLETSPYLLALTIIVSIVHSVFEFLAFKNDIQFWNSRQSLEGLSVRSVFFGVFQSFVVLLYILDNETNFVVQVSVFIGVLIDLWKITKVMDVRLDREHRVAGIFPCPTFKDKSTYIESSTKVYDDMAFRYLSWILFPLLGCYAVYSLLYLEHKGWYSWVLSMLYGFLLTFGFITMTPQLFINYKLKSVAHLPWRMLTYKALNTFIDDLFAFVIKMPVMYRIGCLRDDVVFFIYLYQRWIYRVDPTRVNEFGMSGEDVSAAASRAQASTAAGALTPAPSTAVSGEDASTVPKATSGACTASQPQEAPPKPAEDKKKD
Protein: Dynactin subunit 5 (Dynactin subunit p25) (Q9QZB9)
Organism: Mus musculus (Mouse)
Function: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A286ZK88}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9BTE1}.
Interaction partners:
- Dynactin subunit 4
- Actin-related protein 10
- Dynactin subunit 6
- Dynactin subunit 2
- Dynactin subunit 1
- Dynactin subunit 3
- Alpha-centractin
- Beta-centractin
- BICD family-like cargo adapter 1
- F-actin-capping protein subunit beta
Sequence:
MELGELLYNKSEYIETASGNKVSRQSVLCGSQNIVLNGKTIIMNDCIIRGDLANVRVGRHCVVKSRSVIRPPFKKFSKGVAFFPLHIGDHVFIEEDCVVNAAQIGSYVHVGKNCVIGRRCVLKDCCKILDNTVLPPETVVPPFTVFSGCPGLFSGELPECTQELMIDVTKSYYQKFLPLTQV
Protein: Serine protease inhibitor Kazal-type 7 (Esophagus cancer-related gene 2 protein) (ECRG-2) (P58062)
Organism: Homo sapiens (Human)
Function: Probable serine protease inhibitor.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MKITGGLLLLCTVVYFCSSSEAASLSPKKVDCSIYKKYPVVAIPCPITYLPVCGSDYITYGNECHLCTESLKSNGRVQFLHDGSC