wanglab/gogpt-training-data huggingface dataset:
Protein: Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha) (P10827)
Organism: Homo sapiens (Human)
Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Subcellular location: Nucleus.; SUBCELLULAR LOCATION: [Isoform Alpha-2]: Cytoplasm {ECO:0000250|UniProtKB:P63058}. Nucleus {ECO:0000250|UniProtKB:P63058}. Note=When overexpressed found in the cytoplasm where it colocalizes with TACC1. {ECO:0000250|UniProtKB:P63058}.
Interaction partners:
- Nuclear receptor corepressor 1
- Mediator of RNA polymerase II transcription subunit 1
- Nuclear receptor coactivator 1
- Retinoic acid receptor RXR-alpha
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Thyroid hormone receptor beta
- Actin, cytoplasmic 1
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Nuclear receptor corepressor 2
- Phosphatidylinositol 3-kinase regulatory subunit gamma
Sequence:
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP
Protein: Arginine-specific demethylase JMJ22 (EC 1.14.11.-) (Arginine-specific histone demethylase JMJ22) (F-box protein JMJ22) (Jumonji domain-containing protein 22) (AtJMJ22) (Protein JUMONJI 22) ([histone H4]-dimethyl-L-arginine(3) monodemethylase JMJ22) (Q67XX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone demethylase that demethylates 'Arg-3' (H4R3me) of histone H4 with a specific activity for H4R3me2. Involved in the positive regulation of gene expression. Together with JMJ20, regulates positively seed germination by promoting the removal of repressive histone arginine methylations (e.g. H4R3me2) at GA3ox1 and GA3ox2 to trigger gibberellic acid (GA) biosynthesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:22483719}.
Interaction partners:
- At3g57000
- Uncharacterized protein At5g06590
- Aladin
- Proline-rich extensin-like protein EPR1
- DUF724 domain-containing protein 6
- RNA-binding protein BRN2
- Rhodanese-like domain-containing protein 7
- Histone H4
- At2g02170/F5O4.6
- GMP synthase
Sequence:
MPKCKNLLLTSKRRKSKSKRLKLHQHEPESLFPEKEVEEEDEDEGGFKLKIAAPSQEHGVQPLGNLYFNPGAVNVRNTGLGNLQILSDELVLDILGLLGANHLGVLATVTKSFYIFANHEPLWRNLVLEELKGDFLFNGSWRSTYVAAYHPKFKFAGDGESNLKIIDFYSDYLFQSWLCANLEMKPKWLRRDNITRVRGISVEDFITKFEEPNKPVLLEGCLDGWPAIEKWSRDYLTKVVGDVEFAVGPVEMKLEKYFRYSDGAREERPLYLFDPKFAEKVPVLDSEYDVPVYFREDLFGVLGNERPDYRWIIIGPAGSGSSFHIDPNSTSAWNAVITGSKKWVLFPPDVVPPGVHPSPDGAEVACPVSIIEWFMNFYDDTKDWEKKPIECICKAGEVMFVPNGWWHLVINLEESIAITQNYASRSNLLNVLEFLKKPNAKELVSGTTDRENLHDKFKKAIEEAYPGTIQELEKKAEEAKRAEEQRVSFWDSAKTDTFKFSF
Protein: Exocyst complex component EXO70C2 (AtExo70C2) (Exocyst subunit Exo70 family protein C2) (Q9FFX6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28356503, ECO:0000269|PubMed:33519861}. Note=Localized in the cytoplasm of pollen tubes and trichoblast cells. {ECO:0000269|PubMed:28356503}.
Interaction partners:
- Exocyst complex component SEC8
- Exocyst complex component SEC6
- Exocyst complex component SEC5B
- Exocyst complex component SEC5A
- Exocyst complex component SEC3A
- Exocyst complex component SEC10a
- Exocyst complex component EXO84B
- Exocyst complex component SEC10b
- Exocyst complex component SEC15B
- Exocyst complex component EXO84A
Sequence:
MEKNDKDPDHDDKSKGDEKGDVVSDAHPSDDAHHQDGISNENVDVVGNAETDHQDPGDNNVDKVSQGEEAPEIRQTLESLSEELDQFLPTLSLHMEEHKDSTEEKGEDGYFQIPQFVGKFLDLFEEKLSKYDSGEPKTVWYQDPEEVSSLLEAVDRVSKLMGLLLNTKSCLDHHESLINHAGSIQQRAMAFLEDEFRIILEESVTKESVVVTDDSNSQRRSTADQQDHQNDVVVSQDHDQMLVPECGDQEIEYPGYPEDVVVVLRKIAEKMKAGGYGWECREVYLVGRRNILMRTLKQDCEFEKVSIDEVQKMSWDTLEREIPIWNKTFKDCSSLFFPGELKLAERIFPGDEGNLFCIVTHGLAIQFLGFAEAVAMTRRSTEKLFKILDIYETLRDSFPAMEELFPEELRSELRNEVTSARSRLGETAIHIFCDLEHSIKSDSSKTPVPGGAVHPLTRYTMNYLKYSCEYKDTLEQVFKSHSKMEREEEEPVESGNSAFASQLMRIMELLDGNLETKSKQYKDIPLSCIFMMNNGRYIVQKIKGSAEIHEVMGDTWCRRRSSELRNYHKNYQRETWGKLLGFLGHEGLMHNGKIVKPNLKERFKSFNATFDEIHKTQTTWVVNDEQLQSELRVSITAVMIPAYRAFMARFGQYLDPGRQTEKYVKYQPEDIEDLIDQLFEGNTSSSSTATARRRT
Protein: General transcription factor IIH subunit 3 (General transcription factor IIH polypeptide 3) (F5H4K7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368090}.
Interaction partners:
Sequence:
MVSDEDELNLLVIVVDANPIWWGKQALKESQHHHLMPQPPEYLGLQFTLSKCIDAVMVLGNSHLFMNRSNKLAVIASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACV
Protein: UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) (hUXS) (hUXS1) (Q8NBZ7)
Organism: Homo sapiens (Human)
Function: Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q5PQX0}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- UDP-glucose 6-dehydrogenase
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein eS6
Sequence:
MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNMRSIQENGELKIESKIEEMVEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKPARIKKGRTRHS
Protein: tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1) (Q9UET6)
Organism: Homo sapiens (Human)
Function: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:32558197}. Nucleus {ECO:0000269|PubMed:32558197}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:32558197}.
Interaction partners:
- tRNA
- tRNA
- Probable ribosome biogenesis protein RLP24
- WD repeat-containing protein 74
- GTP-binding protein 4
- Ribosome biogenesis protein NSA2 homolog
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Sodium-coupled neutral amino acid transporter 5
- Pescadillo homolog
- Ribosome biogenesis protein BOP1
Sequence:
MGRTSKDKRDVYYRLAKENGWRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLSQKIGGQGSGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKGCPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCAKPRSSRNSSIEAFAVCQGYDPPEGFIPDLSKPLLDHSYDPDFNQLDGPTRIIVPFVTCGDLSSYDSDRSYPLDLEGGSEYKYTPPTQPPISPPYQEACTLKRKGQLAKEIRPQDCPISRVDTFPQPLAAPQCHTLLAPEMEDNEMSCSP
Protein: ATP pyrophosphate-lyase (Adenylyl cyclase) (Q4Q8R1)
Organism: Leishmania major
Interaction partners:
Sequence:
MDCWNTRRDSKEFQHEAVEMDSLQANCGAPNEQAFHDTLVSAAYQLRARQRDTNVSISKAEMEGLVVLTRELENFKQMMKRSEFTVEGTWRIVEDGGMVERFGQQLYAELLTRNPRLRVHFHGVDIEEQSKSLLRMVGTAVHFYQKPQLTVDMFTKAGARHRGYGVNAEVFVEMRNAFMRVFSEFVGTDVFEAVEEEWRKFWKYVLDLLVHGSESAEGERYGKMYEEKMLKTIQADFKLIMERQNKCDLRGQFVSVMYSKAIEMHEELSKFEALKDLRASARVLQAYIDIINNIHDKKLLDEYMRELGGRHTAYNVTVENLQAFTEPFLFTCRHFFEEEWNIAAESRFLWLFEYMIDGISAGMVSDINSIVNLRAPSNSVTFGLIFTDIEASTRLWSKDSKSMSLAVKSHHAMIRRLIADYGAYEVKTVGDSFIIATKDVLVAVKLSLAIQLELMRMAPIAPGFAMVDSTEGHGDPQAWDDRTLRVRIGVEHCTDATATYDTIHRRYDYYGASVNRCARIEAAACGGQILLCRESFEYLKSMPEFHNDPCPHFLRHVEIATPPPKVDSRGLDHFVVVSDVGLASFKGIAEPVHLLSLVPRCLAGRQFTEKFTKVSE
Protein: Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9) (Q9FJ95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Polyol dehydrogenase that catalyzes the NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), ribitol and xylitol as substrates, leading to the C2-oxidized products D-fructose, D-ribulose and D-xylulose, respectively. To a lesser extent, can also oxidize arabitol, mannitol, lactitol and maltitol in vitro. Is required for sorbitol metabolism. Cannot use NADP(+) as the electron acceptor.
Subcellular location: Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:23498864}.
Interaction partners:
- Xylose isomerase
- Probable fructokinase-4
- Probable fructokinase-3
- Probable fructokinase-1
- Probable fructokinase-5
- Probable fructokinase-7
- Probable fructokinase-6, chloroplastic
- Probable fructokinase-2
- Hexokinase-2
- Hexokinase-1
Sequence:
MGKGGMSQGEGSKVEEENMAAWLVGINTLKIQPFLLPSVGPHDVRVRMKAVGICGSDVHYLKTMRCADFVVKEPMVIGHECAGIIEEVGEEVKHLVVGDRVALEPGISCWRCNLCREGRYNLCPEMKFFATPPVHGSLANQVVHPADLCFKLPENVSLEEGAMCEPLSVGVHACRRAEVGPETNVLVMGAGPIGLVTMLAARAFSVPRIVIVDVDENRLAVAKQLGADEIVQVTTNLEDVGSEVEQIQKAMGSNIDVTFDCAGFNKTMSTALAATRCGGKVCLVGMGHGIMTVPLTPAAAREVDVVGVFRYKNTWPLCLEFLTSGKIDVKPLITHRFGFSQKEVEDAFETSARGSNAIKVMFNL
Protein: Urocanate hydratase (Urocanase) (EC 4.2.1.49) (Imidazolonepropionate hydrolase) (Q96N76)
Organism: Homo sapiens (Human)
Interaction partners:
- Histidine ammonia-lyase
- Probable imidazolonepropionase
- Formimidoyltransferase-cyclodeaminase
Sequence:
MSSLQALCSGLPLRPLPENRGRQAGVPHAPVRTPSLSPVEKQLALRNALRYFPPDVQELLAPEFAQELQLYGHIYMYRFCPDIEMRAYPIEQYPCQTKVAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMFYLSKMTEEQTLVMYSGHPLGLFPSSRSAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAARRYLGIEDLAGKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDKAALEKRHRQGWLMEVTDSLDRCIQRLREARKKKEVLSLGYHGNVVALWERLVHELDTTGECLVDLGSDQTSCHNPFNGGYYPVQLSFTEAQSLMASNPAVFKDLVQESLRRQVSAINRLAEEKFFFWDYGNAFLLEAQRAGADVEKKGAGRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDELATSVLEEAIADGVKVSVKLQYMDNIRWIREAARHRLVVGSQARILYSDQKGRVAIAVAINQAIACRRIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTPEAEGRARLMLSWDVSNGVARRCWSGNQKAYEIICQTMQENSTLVVTLPHKVEDERVLQQALQL
Protein: HTH-type transcriptional regulator GolR (Q92ET8)
Organism: Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Function: Involved in the glycerol metabolism. Repressor of the gol operon for glycerol metabolism.
Interaction partners:
- NAD-dependent glycerol dehydrogenase
- PEP-dependent dihydroxyacetone kinase 2, phosphoryl donor subunit DhaM
- Ribose-5-P isomerase B
- PTS-dependent dihydroxyacetone kinase 2, dihydroxyacetone-binding subunit DhaK
- Triosephosphate isomerase 2
- PEP-dependent dihydroxyacetone kinase 2, ADP-binding subunit DhaL
- FruA protein
Sequence:
MFPFERQNKIIHLLDQNNKITVPELSRILDVSISTIRNDLSALEESGMIKKVHGGAVLLKSEEKFTNFNDRIIRNIEEKEAIAKEAATLVKNNQTIILDASSTALALAKELHGFSRLTVITSGLYTAIELKDNPNISVILTGGIVTTNSFTLEGILGANLIENIHADLCFMSAKGFTMEEGLTDFNIYETELKRLLAKRTNKLVALLDHTKMGVISTASITTAENIDLLITDNKINKALYKKFQDAGLPVKIAE
Protein: Plexus, isoform B (A8DYM2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAQNLTMLVAESNSSNNSTTNSNENNNSSNTPVNFKPKDTNGWKDYKKLKTYLILKDQQSEKASHKPESERSYLLRKRSTPAAERTTFVCYTCGTDTPSSQLRLVYCCPNAEREPYYPFIKTMKVYKNASPISPQGMVQVCSTCNEKHSGLAEGGPPPASSSIHSAVGGGSPSAGHSLESNSAMYSTSGAITGNSGAQFGGRNSPSEKSLANSDSMSNVRFRPYETNSNNSNSNTARDLKQIRRSDSRPNSPSSSQGAIENGHGQYPCSICKVLCPSNKMDWLSTSAEHMNSHAMHFPCLKANAVTNNNNNNNNTNNNNNNNNNELNSNRVLACKDCKDYLASQWETMDAERVPLEHRRYNIPSPMLTSSSPNGSRHGAMSINTPPSTPSISSSTPASTSIYCYLCGLHSDLTLARVLYASKEGSRPYFPLLLKHNSLPNAEQLRNNSALVCTFCYHSMLNQWRKYEAQSPSVNPADRKYNWHDYNCHLCGITTYRKRVRALPVNEFPFVKHQKSDDGLLLENGEYAVVCLDCYESLRQQASQHDRFGVPISRRAYNWVPQPPPPEDSPESAVARLPCGERSDRIHINNALRPVPGKKTTSPKQYDKSKEVPPKAGQKRPATSPAPHIPVPHHLQTPPGGGAGGLPGSSVANSPIPSSAGGNALMNHALPNNHIGTPSPQQQHQHQQHQQQQQQQQHQAQQQAQQQAVAAAVQQQLAAGVGLPPGAIGAASASSRGSFAAALRTLAKQADIKEEDVGGDRSVPTSGAGGPPPSSSGPGSLNSVAGRVGSERPGEDRVSSNKKRSPPSPQPPEKIARLSHTPQTASLQPELLARSGFQPYRSDERLMHPAGAFPLEAYSHFAGLQGIPPAFLNPAGLPYTEQLYLEHRYQLFRAAGAHPSHPHAAALYPQMASPYSHLYSMMPGAALGISPAMHDRMKLEEEHRARLAREEEREREIQREKERELREQREKEQREKEQREKEQREREQREKEQREKEARERKLRDEERERERERQQLLTASHHYSNQLYSPLNRNLLGSMIPHLNMSLRGPPGALHGLPGMSHYHAAAANAQRQSPHGAMGLNLGMAGLPGVPPLGGHGPNLQHHLQQAAMGLAHPGAAGLTHPGFSAAALGLGAHPHSLNLSHPHMSPHHPASLAHQLPPHTSSAGGGGLSNSIPVTASSSLSASSPHTSLNLTSSVKLSADQVPTSTPSGGVSGSGMPPTTSSSHIPNMGHYYHHGHLAAMHAAAAAASGMTPTAAHQQQPLSLPSSPKITPPITPSSSANGGRAGGSPHAMRHHIAAAVAAAAQQSAMIDKAATPVTHEPTTLDLTGSNSNSSNQAPSNASSGQPTNHEVNGAESNGASQTESKEHLAIKEDGHKSSPPPVALEKKPATPNAAADKPIHPDSSPENSSRRSASPQSDANNSLPAVSVTAAASGKCKEETPKILDSDTTATTKTDIEEEKQRARLSVSPTPTAPKIMVASPDTVSTSGGVTSTTSGTTPPPVVSSSTSSAGKAPALTSDEVSTSAATSAAEPTR
Protein: NHL repeat-containing protein 2 (Q8NBF2)
Organism: Homo sapiens (Human)
Function: Required for normal embryonic development.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:30239752}.
Interaction partners:
Sequence:
MAAPGGRGRSLSGLLPAQTSLEYALLDAVTQQEKDSLVYQYLQKVDGWEQDLSVPEFPEGLEWLNTEEPISVYKDLCGKIVVLDFFTYCCINCIHLLPDLHALEHTYSDKDGLLIIGVHSAKFPNEKVLDNIKSAVLRYNITHPMVNDADASLWQELEVSCWPTLVILGPRGNMLFSLIGEGHKDKLFLYTSIALKYYKDRGQIRDNKIGIKLYKDSLPPSPLLFPGKVTVDQVTDRLVIADTGHHRILVVWKNGQIQYSIGGPNPGRKDGIFSESTFNSPQGVAIMNNIIYVADTENHLIRKIDLEAEKVSTVAGIGIQGTDKEGGAKGEQQPISSPWDVVFGTSGSEVQRGDILWIAMAGTHQIWALLLDSGKLPKKNELTKGTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLASEDPWSCLFVADSESSTVRTVSLKDGAVKHLVGGERDPMNLFAFGDVDGVGINAKLQHPLGVTWDKKRNLLYVADSYNHKIKVVDPKTKNCTTLAGTGDTNNVTSSSFTESTFNEPGGLCIGENGELLYVADTNNHQIKVMDLETKMVSVLPIFRSENAVVDGPFLVEKQKTLPKLPKSAPSIRLSPVTACAGQTLQFKLRLDLPSGSKLTEGVSSCWFLTAEGNEWLLQGQIAAGDIENISSQPTISLQIPDDCLSLEAIVSVSVFLYYCSADSSACMMKAILFSQPLQITDTQQGCIAPVELRYVF
Protein: Tumor protein 63 (p63) (F1NWD0)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003304}.
Interaction partners:
Sequence:
MLYLENNAQSQYSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTEHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQGTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSQSSYGSNSPPLSKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGTNIPMMGTHMAMTGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE
Protein: Galectin-12 (Gal-12) (Q91VD1)
Organism: Mus musculus (Mouse)
Function: Binds lactose. May participate in the apoptosis of adipocytes.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MSTDEHLDPIPDSFILQPPVFHPVIPYGTTIFGGLYAGKMVTLQGVVPLHARRFQVDFQCGCCLHPQPDVAFRFSPRFYTVKPHVICNTHQGGLWQKEIRWPGVALQRGDSFLILFLFENEEVKVSVNGQHFLHYRYRLPLSRVDTLDISGDILVKAVGFLNINPFVEGSREYPVGYPFLLYSPRLEVPCSRALPRGLWPGQVIVVRGLVLKEPKDFTLSLKDGTTHVPVTLRASFTDRTLAWVSSWGRKKLISAPFLFHPQRFFEVLLLCQEGGLKLALNGQGLGATSLDQKALEQLRELRISGNVHLYCVHC
Protein: Cyp6g1 ortholog (EC 1.14.-.-) (B4MY86)
Organism: Drosophila willistoni (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Microsome membrane {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004174}.
Interaction partners:
Sequence:
MALTEALLLIAAGLGAIYLWFQRNHSYWQRKGLPYIPPTPIIGNTKAVFKLENSFGLHLSEIYNDPRMKNEAVVGMYSINKPGLVIRDPELVKSILIKDFNRFHNRYGQCDPHGDPLASNNLFFVRNNAWKEMRTKLTPVFTSGKIKQMYSLMLEIADDLELHLSKYPNKFITEIKEVCAQFTTDTIASTAFGIRAHSLHNPDAEFRYHGRKLFTFTLSRAKDFFVAFFVPKLVGLFRIKFFAPEFSHFMRSTISHVIEDRERTGTVRNDLIDVFVGLRKEAAQEPNKPHYARNKDFLVAQAGLFFTAGFETSSSTMSFTLYEMAKHPELQQRLRDEIVGALVEEGGKLSYERINSLEYLSMVVDEVLRLYPVLPFLDREYKSVKGEPDWSLKPYYDFSLENGTPVFIPIYGLQRDPKYWPNPNQFDPERFAPENRKSIDTRIYQPFGSGPHNCIGSRIGLLQTKLGLVHFLKNHYVRTCADTIKEMKFDPKGFVLQSLTGIHLETVNDCLYDEKVKQ
Protein: Arginine-hydroxylase NDUFAF5, mitochondrial (EC 1.-.-.-) (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5) (Putative methyltransferase NDUFAF5) (EC 2.1.1.-) (Q5TEU4)
Organism: Homo sapiens (Human)
Function: Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of NDUFS7. May also have methyltransferase activity (Probable).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:18940309, ECO:0000269|PubMed:27226634, ECO:0000269|PubMed:35614220}. Note=Peripherally localized on the matrix face of the mitochondrial inner membrane. {ECO:0000269|PubMed:18940309}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex assembly factor 3
- NADH dehydrogenase complex I, assembly factor 6
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex assembly factor 4
- NADH dehydrogenase 1 alpha subcomplex assembly factor 8
- NADH dehydrogenase 1 alpha subcomplex assembly factor 2
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- Protein arginine methyltransferase NDUFAF7, mitochondrial
Sequence:
MLRPAGLWRLCRRPWAARVPAENLGRREVTSGVSPRGSTSPRTLNIFDRDLKRKQKNWAARQPEPTKFDYLKEEVGSRIADRVYDIPRNFPLALDLGCGRGYIAQYLNKETIGKFFQADIAENALKNSSETEIPTVSVLADEEFLPFKENTFDLVVSSLSLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLQGMGESNCAWNRKALLHRDTMLAAAAVYREMYRNEDGSVPATYQIYYMIGWKYHESQARPAERGSATVSFGELGKINNLMPPGKKSQ
Protein: Frataxin, mitochondrial (Fxn) (EC 1.16.3.1) [Cleaved into: Frataxin intermediate form; Frataxin mature form; Extramitochondrial frataxin] (O35943)
Organism: Mus musculus (Mouse)
Function: Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly. Accelerates sulfur transfer from NFS1 persulfide intermediate to ISCU and to small thiols such as L-cysteine and glutathione leading to persulfuration of these thiols and ultimately sulfide release. Binds ferrous ion and is released from FXN upon the addition of both L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. May function as an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation. May play a role as a high affinity iron binding partner for FECH that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis (By similarity).
Subcellular location: [Frataxin mature form]: Mitochondrion {ECO:0000269|PubMed:17597094, ECO:0000269|PubMed:9241270}.; SUBCELLULAR LOCATION: [Extramitochondrial frataxin]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q16595}.
Interaction partners:
- Cysteine desulfurase
- Iron-sulfur cluster assembly enzyme ISCU
- LYR motif-containing protein 4
- Ferrochelatase, mitochondrial
- Heme oxygenase 1
- Ceruloplasmin
- Hephaestin
- Heme oxygenase 2
- Ferredoxin-2, mitochondrial
- Aconitate hydratase, mitochondrial
Sequence:
MWAFGGRAAVGLLPRTASRASAWVGNPRWREPIVTCGRRGLHVTVNAGATRHAHLNLHYLQILNIKKQSVCVVHLRNLGTLDNPSSLDETAYERLAEETLDSLAEFFEDLADKPYTLEDYDVSFGDGVLTIKLGGDLGTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLARELTKALNTKLDLSSLAYSGKGT
Protein: Formyl peptide receptor 2 (A0A8I6AM80)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MEANYSVPLNVSEVVVYDSTISRVLWILSMVVLSITFVLGVLGNGLVIWVAGFRMVHTVTTTCYLNLALADFSFTATLPFFVISTAMKEKWPFGWFLCKLVHIVVDINLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLARKVVVGPWILALILTLPIFVFMTTVRVPGGNVYCTFNYASWGKTVEEVLDVANTCETVRGTIRFVIGFTMPMSIVAICYGLIAVKIHRRALVNSSRPLRVLTAVVVSFFICWFPFQLVALLGTIWFKELLFNTRYGILKMWVNPTSSLAYFNSCLNPMLYVFMGQDFRERLIHSLPSSLERALSEDCGQTSDTGTNSALPPADIEIKAI
Protein: Large ribosomal subunit protein mL38 (54S ribosomal protein L35, mitochondrial) (YmL35) (Q06678)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein uL5m
- Large ribosomal subunit protein mL44
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein mL49
Sequence:
MLRRSIHTTKILQKPNATSHIWSDFTTRPSSLSIQSSKVKNYLFQKKASLDPPSISRRSNRIKYSPPEHIDEIFRMSYDFLEQRSSKFYELANKTKNPLKKDALLIKAEINNPEVQYNFQFNNKLNNVKDIIDYDVPVYRHLGKQHWESYGQMLLMQRLETLAAIPDTLPTLVPRAEVNIKFPFSTGVNKWIEPGEFLSSNVTSMRPIFKIQEYELVNVEKQLYTVLIVNPDVPDLSNDSFKTALCYGLVNINLTYNDNLIDPRKFHSSNIIADYLPPVPEKNAGKQRFVVWVFRQPLIEDKQGPNMLEIDRKELSRDDFDIRQFTKKYNLTAIGAHIWRSEWDAKVAAVREKYGLPPGRVFSRVRR