Protein: Ras-related protein rab-6.2 (Q22782)
Organism: Caenorhabditis elegans
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In its active GTP-bound form, acts redundantly with rab-6.1 (in its active GTP-bound form) to positively regulate the retrograde trafficking of cargo molecules from endosomes to the Golgi compartment. Required for the retrograde trafficking of glr-1, a subunit of AMPA-type glutamate receptors (AMPRs), out of early endosomes and into the Golgi compartment in neurons. Its role in glr-1 trafficking may partly be mediated by its interaction with lin-10 and association with components of the retromer complex such as rme-8. Together with rab-6.2, promotes the retrograde trafficking of mig-14 from endosomes to Golgi structures in the intestine. Plays a role in the epidermis to promote cuticle integrity and impermeability of the cuticle barrier to exogenous molecules. May have a role in the glycosylation of the cuticular surface. Required for seam cell division and alae formation. Required for grinder formation, which is the feeding organ that breaks down food. In contrast to rab-6.1, may play a minor role in the exocytosis of secretory vesicles (cortical granules) during the oocyte-to-embryo transition.
Subcellular location: Perikaryon {ECO:0000269|PubMed:22213799, ECO:0000269|PubMed:26891225}. Cell projection, dendrite {ECO:0000269|PubMed:22213799, ECO:0000269|PubMed:26891225}. Golgi apparatus {ECO:0000269|PubMed:21613545, ECO:0000269|PubMed:22213799, ECO:0000269|PubMed:26891225}. Cytoplasmic vesicle {ECO:0000269|PubMed:22992455}. Note=Co-localizes with glr-1 at or near punctate structures in the neuron cell body and along the ventral cord dendrites (PubMed:22213799). Co-localizes with lin-10 in neuronal cell bodies (PubMed:22213799). Co-localizes with rme-8 in neuronal cell bodies and dendrites (PubMed:22213799). Co-localizes with rab-6.1 in neuronal cell bodies and dendrites and in Golgi structures in neurons and the intestine (PubMed:26891225). Co-localizes with vps-52 at Golgi structures (PubMed:21613545). Co-localizes with rab-6.1 at vesicular structures throughout the oocyte cytoplasm (PubMed:22992455). {ECO:0000269|PubMed:21613545, ECO:0000269|PubMed:22213799, ECO:0000269|PubMed:22992455, ECO:0000269|PubMed:26891225}.
Interaction partners:
- Rab GDP dissociation inhibitor
- Ras-related protein rab-6.1
- Protein bicaudal D homolog
- Vacuolar protein sorting-associated protein 39 homolog
- Rab GTPase-activating protein eat-17
- Guanine nucleotide exchange factor subunit R06F6.8
- Rab GTPase-activating protein tbc-11
- Vacuolar protein sorting-associated protein 53 homolog
- Vacuolar protein sorting-associated protein 52 homolog
- ADP-ribosylation factor-like protein 1
Sequence:
MSDFGNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNSNSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLSDKRQVTTDEGERKAKELNVMFIETSAKAGYNVKQLFRRIAGALPGIIKDDPVEPPNVVTMDPIRQRQIVTDEGSCWC