wanglab/gogpt-training-data huggingface dataset:
Protein: Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) (Q8IX03)
Organism: Homo sapiens (Human)
Function: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:18596123}. Nucleus {ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18190796}. Cytoplasm, cytosol {ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:24682284}. Note=Colocalizes with PRKCZ in the perinuclear region.
Interaction partners:
- Dendrin
- Merlin
- Serine/threonine-protein kinase LATS1
- Serine/threonine-protein kinase LATS2
- FERM domain-containing protein 6
- Tyrosine-protein phosphatase non-receptor type 14
- Protein kinase C zeta type
- Uncharacterized protein KIAA0513
- Angiomotin
- Sorting nexin-4
Sequence:
MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLEDSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV
Protein: PaaX domain-containing protein, C-domain protein (O53782)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MPAMTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVALTRMVGAGDLVRSADGYRLSDRLLARQRRQDEAMRPRTRAWHGNWHMLIVTSIGTDARTRAALRTCMHHKRFGELREGVWMRPDNLDLDLESDVAARVRMLTARDEAPADLAGQLWDLSGWTEAGHRLLGDMAAATDMPGRFVVAAAMVRHLLTDPMLPAELLPADWPGAGLRAAYHDFATAMAKRRDATQLLEVT
Protein: Branched-chain amino acid aminotransferase, putative (Q586R0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 3-methyl-2-oxobutanoate dehydrogenase
- 2-oxoisovalerate dehydrogenase subunit alpha
- Homoserine kinase, putative
- Glutamate--cysteine ligase
- Branched-chain amino acid aminotransferase, putative
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- hydroxymethylglutaryl-CoA lyase
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Phosphonopyruvate decarboxylase-like protein, putative
Sequence:
MTFLAKDLTVQRVANPPPLPSLQGVMFGTLFSPHMLVIDADGNGKWGKPRIVPFENLSLPPQTACLHYAIQCFEGMKAYRDSHGNIRLFRPDRNCRRLLDSTRRLCLPGFDPDELQKLIEEFVKVERDYVPSERGYSLYLRPTVIGTGSTLSAVAGSAAKLFVIASPVGPYYPSGMKPVRLHVEEERRRAWPGGVGNVKLGANYAAPMLVQREASELGFQQVLWLGAGEEVQEVGAMNFMCLWRPSANSNEVELVTAPLDGTILPGVTRDSILSLVRQWGEARVSERSFTIHELTAALREKRVLECFGCGTAAIVSPVEALSYKGELLNVPCPAPGASLTHRVLKAITDIQYGDVEHEWSRIVGTTS
Protein: O-antigen chain length regulator (Wzz) (Q7B786)
Organism: Pseudomonas aeruginosa
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MTDEIQKHGGVAGDIDLVELVRGLWEEKWIVLIFSLLGILFAAIYAFLSTPVYEARIAILPPSLSDVAGFNQGRTRETGLGPFKVQDVYSVFVRNLQADGTRHRFFNETYLPSLDEELRSVSRDALYKRFTDQISISLPGKDFPGRYLVAIEQEDPERAASWVRRYIADAAEISIQEMLNNAHREIEVKARDIEQRIQNLRENAKARREDRIVQLKEALKVAGALKLEEPPLISGQSSEELSAIMNGSLMYMRGSKAIMAEIQTLEARSSDDPFIPALRTLQEQQLLLSSLRVNSERVSVFRQDGPIETPDSPVRPRRAMILIFGLIIGGVLGGFLALCRIFLKKYAR
Protein: Cheilanthifoline synthase (CHS) (EC 1.14.19.65) (Cytochrome P450 719A5) (B5UAQ8)
Organism: Eschscholzia californica (California poppy)
Function: Methylenedioxy bridge-forming cytochrome P450 involved in the biosynthesis of isoquinoline alkaloids. Converts (S)-scoulerine into (R,S)-cheilanthifoline. Catalyzes an oxidative reaction that does not incorporate oxygen into the product.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEESLWVVTATVVVVFAIAKLLKKSSSISTMEWPKGPKKLPIIGNLHQLGGEAFHVVLANLAKIHGTVMTIWVGAWRPMIVISDIDKAWEVLVNKSSDYAGRDFPEITKIISANWKNISCSDSGPFWQNLRKGLQGGALAPLNVISQYQLQERDMKNLITSMQEKASKNNGILKPLDYLKEETIRLLSRLIFGQSFNDENFVKGVHLALDDLVRISGYASLADAFKFCENLPSHKKSIREVHEVNERVVNLVKPYLVKNPPTNTYLYFLNSQKFSDEVIISAVLEVYDLGVDSTASTAVWALTFLVREPRVQEKLYKEIIDLTGGERSVKVEDVSKLPYLQAVMKETMRMKPIAPMAIPHKTSRDTSLMGKKVNKGTSIMVNLYAIHHNPKVFPEPYKFIPERFLQGQESKYGDIKEMEQSLLPFSAGMRICAGMELGKLQYGFSLASLVEAFKWTCAVDGKLPDLSEDHCFILLMKNPLEARITPRTQL
Protein: Phosphatidate cytidylyltransferase 4, chloroplastic (EC 2.7.7.41) (CDP-DAG synthase 4) (CDP-DG synthase 4) (CDP-diacylglycerol synthase 4) (CDS4) (CDP-diglyceride pyrophosphorylase 4) (CDP-diglyceride synthase 4) (CTP:phosphatidate cytidylyltransferase 4) (Q94A03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction. Promotes the biosynthesis of plastidial phosphatidylglycerol (PG) which is required for structure and function of thylakoid membranes and, hence, for photoautotrophic growth.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:20442275}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2
- Cardiolipin synthase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1, chloroplastic/mitochondrial
- Phosphatidate phosphatase PAH1
- 1-acyl-sn-glycerol-3-phosphate acyltransferase LPAT1, chloroplastic
- Diacylglycerol kinase 5
- Phospholipase D zeta 1
- Choline/ethanolaminephosphotransferase 1
Sequence:
MATFAELVLSTSRCTCPCRSFTRKPLIRPPLSGLRLPGDTKPLFRSGLGRISVSRRFLTAVARAESDQLGDDDHSKGIDRIHNLQNVEDKQKKASQLKKRVIFGIGIGLPVGCVVLAGGWVFTVALASSVFIGSREYFELVRSRGIAKGMTPPPRYVSRVCSVICALMPILTLYFGNIDILVTSAAFVVAIALLVQRGSPRFAQLSSTMFGLFYCGYLPSFWVKLRCGLAAPALNTGIGRTWPILLGGQAHWTVGLVATLISFSGVIATDTFAFLGGKTFGRTPLTSISPKKTWEGTIVGLVGCIAITILLSKYLSWPQSLFSSVAFGFLNFFGSVFGDLTESMIKRDAGVKDSGSLIPGHGGILDRVDSYIFTGALAYSFIKTSLKLYGV
Protein: Nuclear transport factor 2 (NTF-2) (Nuclear transport factor P10) (P33331)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. In vitro, the NTF2-Ran-GDP association, in the presence of GTP, triggers dissociation of the karyopherin alpha-beta complex, allowing nuclear translocation of karyopherin alpha and the NLS substrate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12065398}.
Interaction partners:
- GTP-binding nuclear protein GSP1/CNR1
- Ran-specific GTPase-activating protein 1
- Nucleoporin NSP1
- GTP-binding nuclear protein GSP2/CNR2
- DNA topoisomerase 3
- mRNA export factor MEX67
- Replication factor A protein 1
- Importin subunit beta-2
- Exportin-1
- Nuclear import protein MOG1
Sequence:
MSLDFNTLAQNFTQFYYNQFDTDRSQLGNLYRNESMLTFETSQLQGAKDIVEKLVSLPFQKVQHRITTLDAQPASPNGDVLVMITGDLLIDEEQNPQRFSQVFHLIPDGNSYYVFNDIFRLNYSA
Protein: Prokineticin receptor 2 (PK-R2) (G-protein coupled receptor 73-like 1) (G-protein coupled receptor I5E) (GPR73b) (GPRg2) (Q8NFJ6)
Organism: Homo sapiens (Human)
Function: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18826963}; Multi-pass membrane protein.
Interaction partners:
- Prokineticin-2
- Prokineticin-1
- Anosmin-1
- Progonadoliberin-1
- Chromodomain-helicase-DNA-binding protein 7
- Fibroblast growth factor receptor 1
- Metastasis-suppressor KiSS-1
- Adenylate cyclase type 3
- NMDA receptor synaptonuclear signaling and neuronal migration factor
- Tachykinin-3
Sequence:
MAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMMLLHWRPSQRGSKSSADLDLRTNGVPTTEEVDCIRLK
Protein: Heat shock protein 20, putative (Q57V53)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- GrpE protein homolog
- AAA+ ATPase domain-containing protein
- AAA+ ATPase domain-containing protein
- ATP-dependent Clp protease subunit, heat shock protein 78
- ATP-dependent Clp protease subunit, heat shock protein 100
- AAA+ ATPase domain-containing protein
- Uncharacterized protein
Sequence:
MWDPFRDIDRIFNRVLPLTGAGSFSSFSRGSWSPAMDLVEKPEGYKLLVDLPGMNREDIQVGIEDNRLCISGNRKSLLKDDEQHLAVFLERGYGRFERCMNLPSPIVEESVKARLRDSVLVVELKKNNSPASSAATSVTIQ
Protein: V-type proton ATPase subunit (A2QE37)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Interaction partners:
Sequence:
MEGLFFNVNSGYIEGIVRGYRNSLLTGQHYSNLTQCETIDDVKLQLAPAYGDFLASLPPNPSTSALAGKMTDKLVAEFRYLLAQATGSTAKFLQYLTYGYMIDNIALLITGTLHERDTRELLERCHPLGWFETLPVLCVATNIEELYNSVLVETPLAGYFKSSLSHQDLDELNIEIVRNTLYKNYLEDFHQFVTTHPDFKGTPTQEVMSEILQFEADRRAINITLNSFGTELSKQERKKLYPEFGKLYPEGSLMLSRADDIESVALAVSISADYKAFFDAVGLTQGGGGLGGMGGSDGKSLEDLFYQKEMELSKVVFTRQFTPAVVYAWMRLKEQEIRNVTWIAECIAQNQKERIGNFISVF
Protein: tRNA wybutosine-synthesizing protein 2 (tRNA-yW-synthesizing protein 2) (EC 2.5.1.114) (tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase) (Q09832)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- tRNA wybutosine-synthesizing protein 3
- Multifunctional methyltransferase subunit trm112
- tRNA wybutosine-synthesizing protein 4
- S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
- 18S rRNA aminocarboxypropyltransferase
- tRNA
- Alpha N-terminal protein methyltransferase 1
- Probable MRF1 mitochondrial N
- tRNA
- Protein-lysine N-methyltransferase efm4
Sequence:
MISFLVQKSEAKYWKDVVQNKNKFLKNIGIISGPKLVDTYSNQFEADFLKKCVLIPTSYNKEDLPKDILDCPRIYLIEEEVKSVQTDEKLQIKVLRYVSQILHTTVSEEQYPVPSRFVIYPPLALLSLNSFGTKEWHLFFQSYANVDVKAGLFDIFAREWNVSHIAINEPIPVGDVMRRPLSLKPLYGDFGVLIDGNPSEQDFQKAFWVSCRQNGIYQTWAPLYTMFSRGNSIEKARVLNFSYIKDEIIADLYAGIGYFTFSYVKAGASTVFCWEINPWSVEALRRAALKNGWSIYVVRNGENYEFKVGTHRIVVFLESNVYAAERFSKMNISARHINLGMLPSSEKSWSTATSILKRESHSFIHVHENVKDEDIETYSSEVNSCFSKMLAKNTVCVTNCVKSFSPRVSHIVYDIETV
Protein: dTDP-epi-vancosaminyltransferase (EC 2.4.1.311) (Glycosyltransferase AH1) (GtfAH1) (Glycosyltransferase GtfA) (P96558)
Organism: Amycolatopsis orientalis (Nocardia orientalis)
Function: Catalyzes the attachment of 4-epi-vancosamine from a TDP donor to the beta-OH-Tyr-6 of the aglycone cosubstrate in the biosynthesis of glycopeptide antibiotic chloroeremomycin, a member of the vancomycin group of antibiotics. Strongly prefers devancoaminyl-vancomycin (DVV) as substrate rather than the heptapeptide vancomycin aglycone (AGV). Acts downstream of GtfB.
Interaction partners:
Sequence:
MRVLITGCGSRGDTEPLVALAARLRELGADARMCLPPDYVERCAEVGVPMVPVGRAVRAGAREPGELPPGAAEVVTEVVAEWFDKVPAAIEGCDAVVTTGLLPAAVAVRSMAEKLGIPYRYTVLSPDHLPSEQSQAERDMYNQGADRLFGDAVNSHRASIGLPPVEHLYDYGYTDQPWLAADPVLSPLRPTDLGTVQTGAWILPDERPLSAELEAFLAAGSTPVYVGFGSSSRPATADAAKMAIKAVRASGRRIVLSRGWADLVLPDDGADCFVVGEVNLQELFGRVAAAIHHDSAGTTLLAMRAGIPQIVVRRVVDNVVEQAYHADRVAELGVGVAVDGPVPTIDSLSAALDTALAPEIRARATTVADTIRADGTTVAAQLLFDAVSLEKPTVPA
Protein: Metadherin (E5RJU9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIDGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET
Protein: Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6) (Q8BGN3)
Organism: Mus musculus (Mouse)
Function: Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Lysophospholipase D GDPD1
- Lysophospholipase D GDPD3
- Lysoplasmalogenase TMEM86B
- Lysophospholipid acyltransferase LPCAT4
- Cytosolic phospholipase A2 epsilon
- Group IIC secretory phospholipase A2
- Cytosolic phospholipase A2 gamma
- Cytosolic phospholipase A2 delta
- Phospholipase B1, membrane-associated
- Cytosolic phospholipase A2
Sequence:
MAAKLWTFLLGFGLSWVWPASAHRKLLVLLLDGFRSDYISEDALASLPGFREIVNRGVKVDYLTPDFPSLSYPNYYTLMTGRHCEVHQMIGNYMWDPRTNKSFDIGVNRDSLMPLWWNGSEPLWITLMKARRKVYMYYWPGCEVEILGVRPTYCLEYKTVPTDINFANAVSDALDSLKSGRADLAAIYHERIDVEGHHYGPSSPQRKDALRAVDTVLKYMIQWIQDRGLQQDLNVILFSDHGMTDIFWMDKVIELSNYISLDDLQQVKDRGPVVSLWPVPGKHSEIYHKLRTVEHMTVYEKESIPNRFYYKKGKFVSPLTLVADEGWFIAESREMLPFWMNSTGKREGWQRGWHGYDNELMDMRGIFLAIGPDFKSNFRAAPIRSVDVYNIMCHVAGITPLPNNGSWSRVVCMLKGQTSSAPPTPLNSCALVLILLLYFV
Protein: Neurogranin (Ng) (RC3) [Cleaved into: NEUG(55-78)] (Q92686)
Organism: Homo sapiens (Human)
Function: Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
Interaction partners:
- Calmodulin-1
- Calmodulin-like protein 6
- Calmodulin-like protein 3
- Calmodulin-like protein 5
- Calmodulin-like protein 4
- Calmodulin-1
- Neuromodulin
- Alpha-synuclein
- Neurofilament light polypeptide
- IQ domain-containing protein J
Sequence:
MDCCTENACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARKKIKSGERGRKGPGPGGPGGAGVARGGAGGGPSGD
Protein: Pentatricopeptide repeat-containing protein At4g16390, chloroplastic (Chloroplastic RNA-binding protein P67) (Protein SUPPRESSOR OF VARIEGATION 7) (Q8GWE0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in chloroplast RNA processing. Can bind RNA. Involved in chloroplast development. Involved in chloroplast ribosomal RNA (rRNA) processing and/or translation. Required for FtsH-mediated chloroplast biogenesis. Involved in translation and accumulation of chloroplast ATP synthase subunits.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:11034340, ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:20935174}. Note=Accumulates in discrete foci within the chloroplast. {ECO:0000269|PubMed:20935174}.
Interaction partners:
- Pentatricopeptide repeat-containing protein At2g17033
- Cytosolic sulfotransferase 1
- Putative elongation factor TypA-like SVR3, chloroplastic
- ATP-dependent zinc metalloprotease FTSH 2, chloroplastic
- Transmembrane protein
- Putative ribosomal large subunit pseudouridine synthase SVR1, chloroplastic
- Photosystem I reaction center subunit IX
- Polyribonucleotide nucleotidyltransferase 1, chloroplastic
- ATP-dependent zinc metalloprotease FTSH 1, chloroplastic
- ATP synthase subunit b, chloroplastic
Sequence:
MSFHHLCSSPSSLLHDPLPLCNLLSVYPKSTPRSFLSSYNPNSSHFHSRNLLQATHVSVQEAIPQSEKSKLVDVDLPIPEPTASKSYVWVNPKSPRASQLRRKSYDSRYSSLIKLAESLDACKPNEADVCDVITGFGGKLFEQDAVVTLNNMTNPETAPLVLNNLLETMKPSREVILYNVTMKVFRKSKDLEKSEKLFDEMLERGIKPDNATFTTIISCARQNGVPKRAVEWFEKMSSFGCEPDNVTMAAMIDAYGRAGNVDMALSLYDRARTEKWRIDAVTFSTLIRIYGVSGNYDGCLNIYEEMKALGVKPNLVIYNRLIDSMGRAKRPWQAKIIYKDLITNGFTPNWSTYAALVRAYGRARYGDDALAIYREMKEKGLSLTVILYNTLLSMCADNRYVDEAFEIFQDMKNCETCDPDSWTFSSLITVYACSGRVSEAEAALLQMREAGFEPTLFVLTSVIQCYGKAKQVDDVVRTFDQVLELGITPDDRFCGCLLNVMTQTPSEEIGKLIGCVEKAKPKLGQVVKMLVEEQNCEEGVFKKEASELIDSIGSDVKKAYLNCLIDLCVNLNKLERACEILQLGLEYDIYTGLQSKSATQWSLHLKSLSLGAALTALHVWMNDLSEAALESGEEFPPLLGINTGHGKHKYSDKGLAAVFESHLKELNAPFHEAPDKVGWFLTTSVAAKAWLESRRSAGGVSA
Protein: ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55) (Q8NHQ9)
Organism: Homo sapiens (Human)
Function: Probable ATP-binding RNA helicase.
Interaction partners:
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- Ribosome biogenesis protein BOP1
- Ribosome biogenesis protein WDR12
- GTP-binding protein 4
- Nucleolar protein 12
- Nucleolar complex protein 3 homolog
- MKI67 FHA domain-interacting nucleolar phosphoprotein
- Nucleolar complex protein 2 homolog
- 28S rRNA
- Probable ribosome biogenesis protein RLP24
Sequence:
MEHVTEGSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKYKRNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLPMEESYINFLAINQKCPLQEMKPQRNTADLLPKLKSMALADRAVFEKGMKAFVSYVQAYAKHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVNTDTIPFKDKIREKQRQKLLEQQRREKTENEGRRKFIKNKAWSKQKAKKEKKKKMNEKRKREEGSDIEDEDMEELLNDTRLLKKLKKGKITEEEFEKGLLTTGKRTIKTVDLGISDLEDDC
Protein: HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A) (P04439)
Organism: Homo sapiens (Human)
Function: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity. Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21263072, ECO:0000269|PubMed:25880248, ECO:0000269|PubMed:8805302}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:8805302}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Killer cell immunoglobulin-like receptor 3DL1
- HLA class I histocompatibility antigen, B alpha chain
- Beta-2-microglobulin
- T-cell surface glycoprotein CD8 alpha chain
- Killer cell immunoglobulin-like receptor 3DL2
- Leukocyte immunoglobulin-like receptor subfamily B member 1
- HLA class I histocompatibility antigen, C alpha chain
- Tapasin
- Calreticulin
- Killer cell immunoglobulin-like receptor 2DL3
Sequence:
MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
Protein: GH16429p (Ras-related GTP binding C/D) (Q7K519)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
- Raptor, isoform B
- GH04846p
- Folliculin
- Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
- Ragulator complex protein LAMTOR1
- Serine/threonine-protein kinase mTor
- Ragulator complex protein LAMTOR2 homolog
- Ragulator complex protein LAMTOR3 homolog
- GATOR complex protein NPRL3
- Ragulator complex protein LAMTOR4 homolog
Sequence:
MSYDDDDYPADTFPKDFGYRAYNQDGLELEPNATGSSETKPRILLMGMRRSGKSSIQKVVFHKMSPNETLFLESTSKIVKDDINNSSFVQFQIWDFPGQIDFFEPTFDSDMIFGGCGALVFVIDAKDDYNEALTKFKNTVLQAYKVNKRIKFEVFIHKVDGISDDSKMESQRDIHQRSSDDLNEAGLDQIHLSFHLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFIPNSGIEKAFLFDVVSKIYIATDSSPVDMQTYELCCDMIDVVIDLSSIYSSEETAFDSGSSSLIKLNNNTILYLREVNKFLALVCILREENFNRQGVIDYNFICFRDAISEVFELRLKRQKQLENNDQDDDDLVDEQTLIRHGHDAGGISRAQPIN
Protein: Myosin motor domain-containing protein (Q9D4I1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MNTLLQRYRAQLPYTCSGPDLITLQPQTTTVPSSGKVPRGRQDGLPAHVTSLAQRAYWALLSQRRDQSIVALGRSGAGKTTCCEQVLEHLVGMAGSVDGRVSVEKLRATFTVLRAFGCVSTGHSRRATRFAMVMSLDFNATGRVTAAQLQTVLLENSRVARQPQGEGNFEVFSQLLAGMDVDLRTELNLHQMAESSAFGMGLWSKPEDKQKAATAFSQLRGAMELLGISEGEQQAIWRVLAAIYHLGAAGACKVGRKQFMRFEWANHAAEALGCDYEELNTATFKHHLRQIIEQMTSGPQRQGLQDNEACSGLKMTGVECVEGMASGLYQELFVAVVSLINRSFSSHHLSMASIMVVDTPGFQNPRHQGKDRAATFEELCYNYAQERLQLLFYHRTFVSTLERYKEEGIPVPFDLPESSPGTTVAVVDQNPSQVHLPAGRGAEDAGGLFWVLDEEVRVQGSSDSTVLERLRAAFEKKKEAGAEEPPSMRTCEQPLQCELFHQLGRDPVRYDLTGWLRRAKPNLAALEAPQILQQSKREELQSLFQARAKLPPVCRAVAGLEGTSQQALHRSRVVRRAFASSLAAVKRKAPCAQIKLQMDALISLLRRSRLHFIHCLVPTTVESKAGQRTPSPSQPSGDQGVANEPTALDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRRFQVLDPALLKKLDLTSEELDERKVVEELLKTLDLEKKAVAVGHSQVSKVTCLDQPPSSLW