wanglab/gogpt-training-data huggingface dataset:
Protein: D(2) dopamine receptor (Dopamine D2 receptor) (P20288)
Organism: Bos taurus (Bovine)
Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P14416}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P14416}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Beta-arrestin-1
- Sodium-dependent dopamine transporter
- Beta-arrestin-2
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide binding protein
- Guanine nucleotide-binding protein G
- Cannabinoid receptor 1
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Sequence:
MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
Protein: Epididymis secretory protein Li 18 (A0A0K0K1K9)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE
Protein: Metalloendopeptidase (EC 3.4.24.-) (B5XA62)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MAPVFVLSIFIAVLCSVQGRSTGKVSFERSEEDMEIDGTSANSIEEDEYSASTLIEKANRNLGQRPDEPLVMFGDIAVYTGFMNADPCTARGCKWRKSSDGNVYVPFVISNEYSARERSVIEGGLRTFAASTCIRFFPRTNQRDFVDIQSQSGCFSFIGRRGNGQVVSLSRNGCVFPSVVQHELLHALGFDHEQTRSDRDSNVQILFQNIMPGMEFNFRKINTINLGTPYDYNSVMHYSRFAFSRNRQPTILPIPDNNAVIGRATEMSPIDILRINRLYNCTGQQLD
Protein: Collectin-12 (A5PMY6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Scavenger receptor that displays several functions associated with host defense. Binds to carbohydrates (By similarity).
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- Cathepsin O
- Apolipoprotein Ba.
Sequence:
MKDDFNDEEEVQSFGYKRFGIQEGNECTKCKNDWALRVAIALLYVLCALLTIAVAVLGYKVVQRMDNVTEGMQNYGGKITAVETDLKKLDDQTGEKSENATSELHSFKLEFQTLQKQLSDVIVKTSNNRAVLKELQLAGEDMQSGHLSLRDLLESNANVISKVNHTLNTYNSLIDGLKTETARLQSDLHVQTSEQGQNSHSISTLNFTQTQQRNLISSLQRSVEDTGQAVQKLKNDYQSLQQVARQTKADADWLREKVQNLQALAANNSLLTRSNSDSLEDVTSQLTTLSEQVQNTSTITDSHDQSLRELMDQQRDHDNATSIRFDALEARLDSNEGEMDRITGNVSFTTQLLRAISTDLNGLRTCSETVTRHSELLHGLNNSVAETRAESTELKAQQEELAVRLDKEVSSLSIVMDEMKLVDNKHSQLITNFTILQGPPGPRGPRGDKGSMGLPGKTGPKGEKGEKGAPGDAGPKGEKGPAGPPGVPGLKGPPGSRGSPGPKGSRGSGGRQGPSGEKGDPGIPGMPGRDGQPGPTGPQGPQGLRGPAGPAGLEGARGPVGPIGPPGPPGLPGLPAPPIVVPPVDPQGFVNRQVAPPPTTTPGCPPQWKGFREQCYHFSAPMESLNFDEAKERCSNLSSSMLIINDEEEQLWIKRQISGKGYFWLGLKWKPGQPDNWSHGHEAGEDCAGLIHEASWNDFFCTERIGFICERTNESKVPVL
Protein: Proteasome subunit beta type-4 (Macropain subunit C11) (Multicatalytic endopeptidase complex subunit C11) (Proteasome component C11) (Proteinase YSCE subunit 11) (P22141)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. This subunit has a chymotrypsin-like activity.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Probable proteasome subunit alpha type-7
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-3
- Proteasome subunit alpha type-6
- 26S proteasome regulatory subunit RPN2
- 26S proteasome regulatory subunit 7 homolog
- Proteasome subunit beta type-7
- 26S proteasome regulatory subunit 6A
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-1
Sequence:
MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAVSSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQIDYLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDLLKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDFQAQ
Protein: ATP-dependent DNA helicase chl1 (EC 5.6.2.3) (Chromosome loss protein 1) (DNA 5'-3' helicase chl1) (O14147)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- RNA polymerase II subunit A C-terminal domain phosphatase ssu72
- mRNA cleavage and polyadenylation specificity factor complex subunit pta1
- Large ribosomal subunit protein uL15A
- Large ribosomal subunit protein uL15B
- Chromosome transmission fidelity protein 18
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription and DNA repair factor IIH subunit ssl1
- General transcription and DNA repair factor IIH subunit tfb1
- General transcription and DNA repair factor IIH subunit tfb4
- General transcription and DNA repair factor IIH subunit tfb2
Sequence:
MCHSKEVKFKTNFHHPYTPYDIQLEFMRSLYSSISDGKIGIFESPTGTGKSLSLICASLTWLDEHGGVLLEDNEKSNDNKSNTSSKIPDWVLEQDLKIQKDLVKETHARLEQRLEEIRKRNQSRKNQMSNNSTTYHRETKRRNINAEASTSDNCNNSNTSVDPMDEYLVTAEYTMPSTSEQSEDLFNNGYSSKVSELLRKLSPDNEKPPIVQKIYFTSRTHSQLQQLVQEIKKLNNQTFSTPIRVVSLASRKNLCINNEVRKLRPTSALNEKCIELQGSAHKCPFLQDNTQLWDFRDEALAEIMDIEELVELGQRLKVCPYYGTREAVDSAQIVTLPYPLLLQESARNALNLTLKDNICIIDEAHNLIDAICSMHSSSISFRQVCIAETQLQQYFLRFEKRLNGNNRMHIKQLIKVVYNLKSFFLNCLETNTNSKVINVDSLLVSNGADQINLHHLSEYLNVSKLARKVDGYTKYMHSLGTQELESLNDLRSERFSNGNGYEEDPYTPVLMQLESFLLNIANPAPEGKLFYEKQTGDNPYLKYLLLDPSKHVEILTEQCRSVNLAGGTMSPIDDFITLLFSDEQSRILPFSCDHIVPPENITTILVSQGPAGVPFEFTHKRKDDENLLKDLGRTFQNFISIIPDGVVVFFPSFAFLQQAVKVWEMNGITNRLNAKKPLFIESKDFGDNPLDTFEHYKQSVDAGLSGMLFSVIGGRLSEGINFSDKLGRAVMVVGMPFPNSQDVEWQAKVSYVEEKAKEKGINAKQASQEFYENTCMRAVNQSIGRAIRHRDDYASIILLDSRYNRSSIQRKLPNWLSKNIHSSPNFGPAIRQLATFFRAKKMCD
Protein: ELKS/RAB6-interacting/CAST family member 2 (O44490)
Organism: Caenorhabditis elegans
Subcellular location: Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
- Rab-3-interacting molecule unc-10
- Liprin-alpha
- Rho GTPase-activating protein syd-1
- Variant SH3 domain protein
- Ras-related protein Rab-3
- Arf-GAP domain-containing protein
- ATP-grasp domain-containing protein
- Phorbol ester/diacylglycerol-binding protein unc-13
- Arginine/serine-rich protein PNISR
- Synaptobrevin-1
Sequence:
MAPGPAPYSSRTSVMNSSGRNPMNYPSVPPHTSISAASRRPLQRQHRSMDGLGVLDAYKDSLDYDMMLQPSPPKPLHQPSYLPLEISTSQHHHPPHHHPTQFQRGQSLALSNPIPTQNAFWQHNNSMATTSVQDYDLMQPGISRIPTGTGSGLNIAREYEQLKVEYDTMMEKLNQTMNSIKTFWSPELKRERQMRRDEATRIAQLERMVQSGGGGGNDYGLGSSEALQLRMELRERDERIRQLTTALESGSGGMDGRIRELEDTIMRLQDLLTTKETQSMMASQDPSGRQAIENALRRIDEKQARIVELEEELMRQRMGRSNQPRDFTDKNLSGHEMATMRMKMDRSEVELAEKKQELFGCQTRMQTAEETANEMRGHLQLLKDQLTNREQHNTLLQGDVDALRQKLDSKNKQLEQKDERVAALERDLSSSKADVSDKGELIRQTEMKTSQLIGRVDSLETTVREKEQELDRAKIRLLSHPDVVKEKEMTEKIEQGERERQRLAEHIDQVRRNAEKDAMEQQKTYQNEMTQLKATIENLQKELSDRDILLESQNEKIGDMNRDLVQAKKRLDDAMVDKGTDELRRDVEGARNEVEKLLKMVHSLEKENLTLTAQCKQLKRDDTPRAGTTSAPSAPGTLTRSTSAQNNMHKRIEELEEALRESVSITAEREVHLSQQKHHLQQVSSQLNEARKEITELRRTKQNPSETGDRDQIIRAIETERRQHLEQLFQLKQEALLAAISEKDTHLALLEKSRGPRDEIETIRRHKDALIRKLKQENERRVLVSHPDPVISMNAMASVIPGAPLPAPVIPGTIGIPQHSQHPPQVDHDDADGIWA
Protein: Nucleosome assembly protein 1;1 (AtNAP1;1) (Nucleosome/chromatin assembly factor group A1) (Q9SZI2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May modulate chromatin structure by regulation of nucleosome assembly/disassembly (By similarity). Contributes to the regulation of cell proliferation and cell expansion. May function in nucleotide excision repair (NER). Involved in somatic homologous recombination.
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly located in cytoplasm. Shuttles between cytoplasm and nucleus depending on stage of the cell cycle. Farnelysation favors the location to the nucleus early in leaf development.
Interaction partners:
- Protein NAP1
- At2g45860
- ARM repeat superfamily protein
- Telomerase reverse transcriptase
- Histone H2B.6
- Nodulin-related protein 1
- Small ribosomal subunit protein eS6y
- Probable histone H2A.2
- Small ribosomal subunit protein eS6z
- Expressed protein
Sequence:
MSNDKDSFNVSDLTAALKDEDRAGLVNALKNKLQNLAGQRSDVLENLTPNVRKRVDALRDIQSQHDELEAKFREERAILEAKYQTLYQPLYVKRYEIVNGTTEVELAPEDDTKVDQGEEKTAEEKGVPSFWLTALKNNDVISEEVTERDEGALKYLKDIKWCKIEEPKGFKLEFFFDTNPYFKNTVLTKSYHMIDEDEPLLEKAMGTEIDWYPGKCLTQKILKKKPKKGSKNTKPITKLEDCESFFNFFSPPEVPDEDEDIDEERAEDLQNLMEQDYDIGSTIREKIIPRAVSWFTGEAMEAEDFEIDDDEEDDIDEDEDEEDEEDEEDDDDEDEEESKTKKKPSIGNKKGGRSQIVGEGKQDERPPECKQQ
Protein: RHS4a (Q8T9M5)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MNQQVPIEGRGDIEGRRRENEEAARNDAEPPAVQQRVENNNQPRWGLFSSVEAVLLNGRAHPENVTLNDFLRRNFGRRYNVNEENNVSMFVFVLEPEEYINDVNALNRIFATTEYQVYQVFATAYPLLFREGILNLQRWQQADEVVKAGLQVNIRGLRDGERLWIIVTNMLNDALNVALERAAQTAASAVELKGVYDSIYNAKWSYVMSGYDEEPLGMKVFDGKPQHIWTEAEVDITPDPANVDAEIEERPNGLEIFVLTSEKGWPYNGFSLCLRKKCRAICNHVYIRREIMRVWYIIQRGLQTWWLNDTAHRPPIHIVIGTPGIGKSYGVGSFLLHSLLHFNDGMLDVVAYFTDGNAFLIYNKKPGEEERVVQYEHVKAAVKAIDAVKYEKKGHVIVDISEKNETPPQNLPSPFWGVTILTSPDTAHYEHWAKNRGDRHIIINCDDVRDMKAFVAWKKLCVLSEEAPRDKTRQQLMEELESEWKIVEERIDMVGPLPRFVFSAPDYDARLECVRKEARQLDSENGKKYDKIIGKSSDWQNDVVTHKLVKIVRVSSGTVNVESYRCRSLSVNIWNMLICTLFGILIVEMTSKEIIMSDESVGANAFERLALLSLLFPRVFKVIANNLKYLRRGREIADRRSILNDMAPQQLRLIGQKALPAAQQRPIERCEHMVLYLPATGNEPVVDGFFFVEGRLRRNRDGTAPPTTPNIAVLLQVTKSERHPTTTDKVQKFRENIASYFSDWNTFSGNMAWEMIYINSVNGGTITRRQLCEGPPDRAGGEDGGPLGPQTFWESIDQFQVTLKETMQAELIQAYRRESGMRDAPALMGLAGRRRAREEVVEGRGDVAMDDVEGGEDA
Protein: Metalloprotease TIKI2 (EC 3.4.-.-) (Heart, kidney and adipose-enriched transmembrane protein homolog) (TRAB domain-containing protein 2B) (A6NFA1)
Organism: Homo sapiens (Human)
Function: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22726442}; Single-pass type I membrane protein {ECO:0000269|PubMed:22726442}.
Interaction partners:
Sequence:
MHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWTIRRDPPAYLFGTIHVPYTRVWDFIPDNSKAAFQASTRVYFELDLTDPYTISALASCQLLPHGENLQDVLPHELYWRLKRHLDYVKLMMPSWMTPAQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTERDVRFRGVPVLDLYLAQQAEKMKKTTGAVEQVEEQCHPLNNGLNFSQVLFALNQTLLQQESVRAGSLQASYTTEDLIKHYNCGDLSAVIFNHDTSQLPNFINTTLPPHEQVTAQEIDSYFRQELIYKRNERMGKRVMALLRENEDKICFFAFGAGHFLGNNTVIDILRQAGLEVDHTPAGQAIHSPAPQSPAPSPEGTSTSPAPVTPAAAVPEAPSVTPTAPPEDEDPALSPHLLLPDSLSQLEEFGRQRKWHKRQSTHQRPRQFNDLWVRIEDSTTASPPPLPLQPTHSSGTAKPPFQLSDQLQQQDPPGPASSSAPTLGLLPAIATTIAVCFLLHSLGPS
Protein: Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1) (P35467)
Organism: Rattus norvegicus (Rat)
Function: Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P23297}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:P23297}. Mitochondrion {ECO:0000250|UniProtKB:P56565}.
Interaction partners:
- Ryanodine receptor 2
- Ryanodine receptor 1
- Inositol 1,4,5-trisphosphate/ryanodine receptor domain-containing protein
- F-actin-capping protein subunit alpha-2
- F-actin-capping protein subunit alpha-1
Sequence:
MGSELETAMETLINVFHAHSGKEGDKYKLSKKELKDLLQTELSSFLDVQKDADAVDKIMKELDENGDGEVDFQEFVVLVAALTVACNNFFWENS
Protein: Optic atrophy 1, isoform E (A0A0B4LF33)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLRIYQNTYRRTARKAVVYSTKVACCNHSTLCGITSHPRRAQDSGSSSSNGRHRGHEEFLLAGNPARGWQMPPPSRGYGMLVVRILRGALKLRYIVLGGAIGGGVSLSKKYEEWKDGLPNFKWLEDAMPQGERWSQFSRNLIEVGSLVKNAIEVAKDDLKAKTTVAALGITSDESRKKYEKLQSQVETLQTEIMNVQIKYQKELEKMEKENRELRQQYLILKTNKKTTAKKIKKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKDDSIDAIRQYEEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQSNIL
Protein: E3 ubiquitin-protein ligase RNF (EC 2.3.2.27) (RING finger protein) (A0A024RCQ4)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Mitochondrion membrane {ECO:0000256|RuleBase:RU369090}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU369090}. Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU369090}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU369090}.
Interaction partners:
Sequence:
MAAAEEEDGGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFNAHEPFRRGTGVDLGQGHPASSWQDSLFLFLAIFFFFWLLSI
Protein: Modifier of cell death (B7FAS0)
Organism: Caenorhabditis elegans
Function: Promotes programmed cell death. Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins dpl-1 and lin-35, and is independent of the ced-1, ced-8 and ced-9 pathways.
Interaction partners:
- Zinc finger protein zfp-2
Sequence:
METAPDEAPTEFLEPGEEIVENVIEEEVVHEEDVEHHEEDGEMIEVQHEEVLEEIVEEDGMMFDTDGRVIEYSDVMVYEEGTEVIEEYVEVEDLGDGRYAYVMTDDIGHRRLLKPHEVEAVKKMPGMMEEEVVMDDEKAPNTSYAAAQKRGRFPPQARSSLSPQKPRAAGAYMGPEAYYQQPKRMTHMAKVDVEKYSPVTPVNRRPLMDNAIFKSKLPRKSAPWQEETAANGGPQSTSLIRSPSPMLKEPLFDDNEIRFKCAECGDGFPVMDRLCDHMIKQHDCQTNVREVQFFADRDFENFLLKVEKATLGRDPEDAIRKKSRAGSSQLFVCNYMNKGRQKMAELVEVGIVGLSERPLEVCTAFVQKTHGYECIRVKYCDQHIHYDGNIGFRVPIAVKRRLFEMSFKRLPIPCMQIMLGLEAEQLLPHPTRFEEKLKNLSHVEIIELLQIINASLRKHQEVEPRGKKVPIKFETIKSSEGSQTLMVKRVTPPKKEHMDYDEPDPNIPSTSAQALGYNPDDDEGDDVPMMSREEEVLDDETGEESVMTEDCDGMMEDNMLYDPENNRDPLFDELTEVELGVLDAYEHDIEIALTEAQKKERTRLKAKFALNKVIGIYQTLDTATHGLTAGELHTDTINHLRDMASYVVELVCQIDAEVKVRRNPALRIDDVKRDMIAGIAMQERVHQPERRPRRSAAPASPAKPQYRPQPPARSHEEYTQRIMNKVKEYMPRRRPDAYDLQQGQQQSRLQMLREQTLLRAPLEEEKPPVATMAPVPDEHKAIPWTRPGRKRAMGPGEAATAPAKRRGRPTKKEEAAEAAAKLIQAENEMVVEEEEVEEPPVVEQEQVPKEKEVEVAEAEKLPEQVKTEPSVTPSSAPPTPATTATKTRTGRVVKPKKWDDN
Protein: Histone-lysine N-methyltransferase Smyd1 (EC 2.1.1.354) (CD8b-opposite) (SET and MYND domain-containing protein 1) (Zinc finger protein BOP) (m-BOP) (P97443)
Organism: Mus musculus (Mouse)
Function: Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11923873}. Nucleus {ECO:0000269|PubMed:11923873}.
Interaction partners:
- Nascent polypeptide-associated complex subunit alpha, muscle-specific form
- Protein-lysine N-trimethyltransferase SMYD5
- Cellular tumor antigen p53
Sequence:
MTIGSMENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFDSLINFVCHTCFKRQEKLHRCGQCKFAHYCDRTCQKDAWLNHKNECAAIKKYGKVPNENIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLHLSEERRRQLKKQYYFDCSCEHCQKGLKDDLFLAAKEDPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNLYVLRLLSIASEVLSYLQAYEEASHYARRMVDGYMKLYHHNNAQLGMAVMRAGLTNWHAGHIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRMQTEMELRMFRQNEFMYHKMREAALNNQPMQVMAEPSNEPAPALFHKKQ
Protein: Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (K7IM66)
Organism: Nasonia vitripennis (Parasitic wasp)
Function: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
Subcellular location: Cytoplasm {ECO:0000255, ECO:0000255|HAMAP-Rule:MF_03003}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit F
- W2 domain-containing protein.
- S1 motif domain-containing protein.
- Tr-type G domain-containing protein.
Sequence:
MANDENTDGVNKSEKMEKMCEFIRPMVQNNPDGWGPCELPDQFKDIPYQPFSKSDRLGKISDWTGTAYQDKKFQNKYNSQFGGSGMKAYAYEHDEDETTFHLVDTTRVQKPPYQRGRFGQRNQRMRGRGGQRGGMSQMQALGKLKIHERDRRGQNKRWTRRNQAPIKMRDASVTVRPDWVTIEEMDFPRLSKLTLPGVKEGEDVLCCGAVEYYDKSYDRVNVKNEKPLQRIDRIFHTVTTTDDPVIRKLSKTEGNVYATDAILATIMCCTRSNYSWDIVIEKIGNKLFFDKRDNTEFDLLTVNETSVEPPQDDGNSLNSPRNLALEATFINHNFSQQVLKSNEPRYKFDEPNPFISEEEEGEVASVAYRYRKWDLNNGITLIARCEHDAVMQGPNNETQFLTIKALNEWDSKLANGVEWRRKLDTQRGAVLANELRNNACKLAKWTVQALLAGSDQLKFGYVSRASVRDSSKHVILETQQYKPNEFATQINLNMDNAWGILRCIIDICMNQKDGKYLIMKDPNKPMIRLYDIPDNTFESEGEEEDSDEEEQVKDAFQR
Protein: Calcium-transporting ATPase 5, plasma membrane-type (OsACA5) (EC 7.2.2.10) (Ca(2+)-ATPase isoform 5) (OsACA6) (Q7X8B5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell, into the endoplasmic reticulum, or into organelles (By similarity). Involved in salt and drought stress tolerance. Involved in cold stress tolerance.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24128296}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Os05g0120700 protein
- protein-serine/threonine phosphatase
Sequence:
MESASSSLATSGRRRSSSGGGGGSWGSIGSAADPFDIPAKGAPVESLKKWRQAALVLNASRRFRYTLDLKREEQREEVISKIRAQAHVVRAAFRFKEAGQVHVQQKEVAAPPVDGALGFGIKEDQLTALTRDHNYSALQQYGGISGVARMLKTDTEKGISGDDSDLTARRNAFGSNTYPRKKGRSFLAFLWDACKDLTLIILMVAAAVSLALGITTEGIKEGWYDGASIAFAVLLVVVVTATSDYKQSLQFQNLNEEKQNIKLEVVRGGRRISVSIYDLVAGDVVPLKIGDQVPADGILISGHSLSVDESSMTGESKIVHKDQKSPFLMSGCKVADGYGTMLVTAVGINTEWGLLMASISEDSGEETPLQVRLNGVATFIGMVGLSVALAVLVVLLARYFTGHTYNPDGSVQYVKGKMGVGQTIRGIVGIFTVAVTIVVVAVPEGLPLAVTLTLAFSMRKMMRDKALVRRLSACETMGSATTICSDKTGTLTLNQMTVVEAYFGGKKMDPPDNVQVLSASISSLIVEGIAQNTSGSIFEPENGQDPEVTGSPTEKAILSWGLKLGMRFNDTRTKSSILHVFPFNSEKKRGGVAVHLGGSESEVHIHWKGAAEIILDSCKSWLAADGSKHSMTPEKISEFKKFIEDMAASSLRCVAFAYRTYEMVDVPSEDRRADWILPEDDLIMLGIVGIKDPCRPGVKDSVRLCAAAGIKVRMVTGDNLQTARAIALECGILSDPNVSEPVIIEGKAFRALSDLEREEAAEKISVMGRSSPNDKLLLVKALRKRGHVVAVTGDGTNDAPALHEADIGLSMGIQGTEVAKESSDIIILDDNFASVVRVVRWGRSVYANIQKFIQFQLTVNVAALIINVVAAVSSGNVPLNAVQLLWVNLIMDTLGALALATEPPTDHLMQRPPVGRREPLITNVMWRNLIIMALFQVIVLLTLNFRGTSLLQLKNDNQAHADKVKNTFIFNTFVLCQVFNEFNARKPDELNIFKGITGNHLFMAIVAITVVLQALIVEFLGKFTSTTRLTWQLWLVSIGLAFFSWPLAFVGKLIPVPERPLGDFFACCCPGSKQAADAKGDDADHSDV
Protein: tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) (Q9NXH9)
Organism: Homo sapiens (Human)
Function: Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Interaction partners:
- tRNA
- Replication termination factor 2
- Pseudouridylate synthase TRUB1
- tRNA
- RNA cytosine C
- tRNA
- tRNA
- 28S rRNA
- tRNA-dihydrouridine
- tRNA
Sequence:
MQGSSLWLSLTFRSARVLSRARFFEWQSPGLPNTAAMENGTGPYGEERPREVQETTVTEGAAKIAFPSANEVFYNPVQEFNRDLTCAVITEFARIQLGAKGIQIKVPGEKDTQKVVVDLSEQEEEKVELKESENLASGDQPRTAAVGEICEEGLHVLEGLAASGLRSIRFALEVPGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYQHQRVSERFDVIDLDPYGSPATFLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCPETSNQTPPGPGAAAGPGID
Protein: Ankyrin repeat domain-containing protein 2B (Q29Q26)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Exhibits chaperone activity toward chloroplast outer envelope membrane, mitochondrion outer membrane, endoplasmic reticulum membrane and peroxisomal proteins, by recruiting specific proteins containing a single transmembrane associated with an AKR2A-binding sequence (ABS) and subsequently binding glycolipids (e.g. monogalactosyldiacylglycerol (MGDG) and phosphatidylglycerol (PG)) present in the membrane of the target organelle.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9SAR5}. Nucleus {ECO:0000250|UniProtKB:Q9SAR5}. Plastid, chloroplast outer membrane {ECO:0000250|UniProtKB:Q9SAR5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9SAR5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9SAR5}.
Interaction partners:
- 2-oxoglutarate
- Outer arm dynein light chain 1 protein
Sequence:
MASSSEKTPLIPSDEKNDTKEESKSTTKPESGSGAPPSPSPTDPGLDFNAFDFSGMAGILNDPSIKELAEQIAKDPSFNQLAEQLQRSVPTGSHEGGLPNFDPQQYMQTMQQVMENPEFRTMAERLGNALVQDPQMSPFLEALGNPAASEQFAERMAQMKEDPELKPILAEIDAGGPSAMMKYWNDKDVLAKLGEAMGIAVGADQTVAAEPEEAEEGEEEESIVHQTASLGDVEGLKAALASGGNKDEEDSEGRTALHFACGYGEVRCAQVLLDAGANANAIDKNKNTPLHYAAGYGRKECVSLLLENGAAVTQQNMDNKNPIDVARLNNQLDVVKLLEKDAFL