wanglab/gogpt-training-data huggingface dataset:
Protein: Wnt ligand secretion mediator (H0YCG9)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004653}.
Interaction partners:
Sequence:
XNMSTKKLCIVGGILLVFQIIAFLVGGLIGENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWML
Protein: Metallothionein-1H (MT-1H) (Metallothionein-0) (MT-0) (Metallothionein-IH) (MT-IH) (P80294)
Organism: Homo sapiens (Human)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Interaction partners:
- Metallothionein
- Metallothionein-1G
- Metallothionein-1F
- Metallothionein-1M
- Metallothionein 1H-like protein 1
- Metallothionein-1X
- Metallothionein-2
Sequence:
MDPNCSCEAGGSCACAGSCKCKKCKCTSCKKSCCSCCPLGCAKCAQGCICKGASEKCSCCA
Protein: Beta-glucuronidase (EC 3.2.1.31) (Q7K173)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MALSIFSLVTGLYVLHFSIALILVNKEVPQTRGMLYPRESETREVRSLDGIWNFVRSDQANPTQGVRDEWYAKELSKSRPTIPMPVPASYNDITTDNLRDHVGTVWYDRKFFVPRSWSKDQRIWLRFGSVHYEAYVWINGQKVVKHEMGHLPFEAEVTDLLSYGAENRITVMCDNALIQTTVPQGRITEVPNDGGMTIVQSYTFDFFNYAGIHRSVHLYTTPRTFIEEVEVTTNLSKDATVGEVFYSVSVNGSAANEADNVLQIQANLYDKDGILVANATSDQKLGGKLQVNPVKPWWPYLMHSEPGYLYQLEIKLLATNDELLDVYRLKVGIRTLSWNSQQFLINGKPVYFRGFGRHEDSDIRGKGLDNALMVRDFNLLKWIGANAYRTSHYPYSEESMQFADEHGIMIIDECPSVDTENFSQELLGKHKSSLEQLIHRDRNHPSVVMWSIANEPRTGSVSADSYFELVANFTRSLDKTRPITAAIAVSNTQDKAGRSLDIISFNRYNAWYSNAGRLDMITQNVIDEAIAWNKRYNKPIIMSEYGADTLEGLHMQPAYVWSEEFQTEVFSRHFKAFDELRKKGWFIGEFVWNFADFKTAQSYTRVGGNKKGVFTRARQPKAAAHLLRKRYFALGRDLDQCSFPEDLFTYIADLIS
Protein: ADP-ribosylation factor GTPase-activating protein GLO3 (ARF GAP GLO3) (P38682)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GTPase-activating protein for the ADP ribosylation factor (ARF) family. Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- ADP-ribosylation factor 1
- Coatomer subunit gamma
- Coatomer subunit beta'
- Coatomer subunit beta
- Coatomer subunit alpha
- ADP-ribosylation factor 2
- Protein transport protein BET1
- Protein transport protein SEC22
- Coatomer subunit delta
- ADP-ribosylation factor-like protein 1
Sequence:
MSNDEGETFATEQTTQQVFQKLGSNMENRVCFDCGNKNPTWTSVPFGVMLCIQCSAVHRNMGVHITFVKSSTLDKWTINNLRRFKLGGNHKARDFFLKNNGKQLLNTANVDAKTKYTSPVAKKYKIHLDKKVQKDMELYPSELVLNGQDSSDSPLDTDSDASRSTSKENSVDDFFSNWQKPSSNSSSKLNVNTGSLAPKNNTTGSTPKTTVTKTRSSILTASRKKPVLNSQDKKKHSILSSSRKPTRLTAKKVDKSQAEDLFDQFKKEAQQEKEDEFTNSSSSTKIRQNDYDSQFMNNSKGNNNNSIDDINTQPDEFNDFLNDTSNSFDTTRKEQQDTLTPKFAKLGFGMTMNDANDLAKQQKESQKIAQGPRYTGRIAERYGTQKAISSDQLFGRGSFDEAANREAHDKLKTFDNATSISSSSYFGEDKEVDEFGNPINSSGSGAGNFDGRNSNNGFIDFNASADDELQMLRDVVEQGAEKLGSYLRDYLRK
Protein: Probable sodium/metabolite cotransporter BASS1, chloroplastic (Bile acid transporter 2) (Bile acid-sodium symporter family protein 1) (Q93YR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as sodium-coupled metabolite transporter across the chloroplast envelope.
Subcellular location: Membrane {ECO:0000305|PubMed:19542295}; Multi-pass membrane protein {ECO:0000305|PubMed:19542295}. Plastid, chloroplast envelope {ECO:0000305|PubMed:19542295}.
Interaction partners:
- Protein COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB3, chloroplastic
- Probable sodium/metabolite cotransporter BASS4, chloroplastic
- D-ribulose kinase
- Expansin-A13
- Acyl-acyl carrier protein thioesterase ATL1, chloroplastic
Sequence:
MASAISLSLLNGATPLKSNSLHKSRLTPLHLRTISCSRLSYSPSSREISLKTQSTVPISCRRSRFDFVPRCGISSNDLPTEKKKSFGEWVEFVGEAVSTAFPIWVSLGCLLGLMRPSTFNWVTPNWTIVGLTITMLGMGMTLTLDDLRGALSMPKELFAGFLLQYSVMPLSAFFVSKLLNLPPHYAAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTVSAVIMTPLLTAKLAKQYITVDALGLLMSTLQVVLLPVLAGAFLNQYFKKLVKFVSPVMPPIAVGTVAILCGYAIGQNASAILMSGKQVVLASCLLHISGFLFGYLFSRILGIDVASSRTISIEVGMQNSVLGVVLATQHFGNPLTAVPCAVSSVCHSILGSVLAGIWRRSAPKQLED
Protein: 5,10-methylenetetrahydrofolate reductase (MTHFR) (EC 1.5.1.54) (NADH-dependent 5,10-methylenetetrahydrofolate reductase) (P0AEZ1)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the NADH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Is required to provide the methyl group necessary for methionine synthetase to convert homocysteine to methionine; the methyl group is given by 5-methyltetrahydrofolate. Can also use NADPH as the reductant, but much less effectively than NADH.
Interaction partners:
- Methionine synthase
- Cystathionine gamma-synthase
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Homoserine O-succinyltransferase
- HTH-type transcriptional regulator MetR
- Serine hydroxymethyltransferase
- Bifunctional protein FolD
- Met repressor
- Aminomethyltransferase
- S-adenosylmethionine synthase
Sequence:
MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL
Protein: G-protein coupled receptor 25 (A0A2S1XYZ5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MASSTEMAHSGITMSLTSEYDYDYPINSTDENPIYTLPDAELLPMSNIYIPVLYIIMFLTGSLGNLFVIVVIGKRRKKSGRLVDTFVLNLALADLVFVLTLPMWAISTRYDEWPFGEVLCKISSFIIAVNRFSNIFFLTCMSVDRYLAVVRLMDSRFLRSSNCAQITCGIVWVVSFFLGSPSLAYRHLINNSVCSEDSKSSFVQGMNLLTILLTFLLPVLILGLCYGSILVNLRRHCHNPANTRTDARRRHSVKIVFAIISAFLISWLPFNCFKAIHVALLIINGDLNEDTYVVIHRGLMLSCCLAFLNSCVNPAIYFFLDQHFRRRASMLCLSCLSQNDQAHQSYITSNSYSNGTSETCSGNTSTRGRLFSLTQKA
Protein: peptidylprolyl isomerase (EC 5.2.1.8) (E1BXG9)
Organism: Gallus gallus (Chicken)
Interaction partners:
- ADP/ATP translocase
- ADP/ATP translocase
- Uncharacterized protein.
- Prostaglandin E synthase 3
- Heat shock cognate protein HSP 90-beta
- Heat shock protein HSP 90-alpha
- Uncharacterized protein.
- Uncharacterized protein.
- RanBD1 domain-containing protein.
- Stress induced phosphoprotein 1.
Sequence:
MSHPSPVERPGNPRNPRAFFDVDIGGERVGRIVFELFADIVPKTAENFRALCTGEKGTGATTGKPLHYKGCPFHRIIKQFMVQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKPGLLSMANAGPGTNGSQFFITTVPTSHLDGKHVVFGQVIKGMGVVKILENVEVNGENPAKLCVIAECGELKEGDDWGIVPQDGSGDTYPDFPEDSDIDLKDVDKIVAIAEDIKNIGNTFFKSQNWAVAAKKYSKSLRYVEASETVAEEGDKPKLKTVGLSCVLNIGACKLKLSDWQGAIESCSEALQIDPANTKALYRRAQGWQGIKDLDQALADLKKAHEIAPEDKAIQTETLKIKQKIKAQKEKEKAAYAKMFA
Protein: Uncharacterized MFS-type transporter C613.02 (O74902)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSISIETITKRNQYRVDQPQRQPSRLSTVASISEYQSDYSKTVFEEIELEVIPNKQNISTRSFRNDGNDSDPQTLDPDAYPPKRSIAFVLLNSILSDMSMSTALPISAAYTEILGGTDAFSGLVIGIPTMISLVCLYPMLRFANPKSANGYTLYFRPLIVSCISQIIGHLLYSLAYRAQWLYLILIGRMCNGVGFTMFLYHKKYLTDKHFVGQNRSTFLATLNILAQTVGFMAGSFLGGLLAKACMHLTNPIWNQYTVGSWFMLFAWCIYGILLSIFFKEIRADGNDSSARKPENFNGQAVKLSYTHKFMLVFLSMVAFISYFNIAGYQASVPIYAKELYHYNAFQSGNFLSLSALVIAPLVFLSTFLSKWAEDRDMMLYGFILGILALVVHLVLDVLHKVRVQPYFVLYSAMQFGFSIGSAPLISLATKQLHPKYHILVGIIVQIGISAADTVGAICGGAIFDITTVGFIALNLGIAVLVFIQLLFLWNSIKTKTG
Protein: Pachytene checkpoint protein 2 homolog (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13) (Q3UA06)
Organism: Mus musculus (Mouse)
Function: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation (By similarity).
Interaction partners:
- Cell division cycle protein 20 homolog
- Mitotic spindle assembly checkpoint protein MAD2A
- MAD2L1-binding protein
- Mitotic spindle assembly checkpoint protein MAD2B
- Cytochrome c1, heme protein, mitochondrial
- Maternal embryonic leucine zipper kinase
- Exonuclease 1
- Meiotic recombination protein DMC1/LIM15 homolog
- HORMA domain-containing protein 1
- Shieldin complex subunit 3
Sequence:
MDEAVGDLKQALPCVAESPAVHVEVLQRSGSTAKKEDIKSSVYRLLNRHNIVFGDYVWTEFDDPFLSRNVQSVSIVDTELKAKDPQPIDLSACTIALHIFQLNEEGPSSENLDEETENIIAASHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTVLFSDKNVDSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLSEISRKSEGLSGRVLRKLPFLAHALYIQAPSVTIEGFLQALSLAVDKQFEEKKKLSAYV
Protein: Elongation factor Tu (EF-Tu) (EC 3.6.5.3) (P9WNN1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00118}.
Interaction partners:
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS12
- Elongation factor Ts
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein bL36
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL23
Sequence:
MAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPDLNETKAFDQIDNAPEERQRGITINIAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADAVDDEELLELVEMEVRELLAAQEFDEDAPVVRVSALKALEGDAKWVASVEELMNAVDESIPDPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGVINVNEEVEIVGIRPSTTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGVKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTNISVKLIQPVAMDEGLRFAIREGGRTVGAGRVTKIIK
Protein: Zinc finger protein 251 (Q6PCX8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MADKSCSPTPGETPLTFQDVAVYFSRAEGQQLSPQERALYRDVMLENYGNVASLGFPGPKPELISQLEQEEELWVLDLLGAEEPEVLRRCQTDSEIEAEKELSILNQKCFEEVKTPEFISPKFPRAYSQASEPQEACAHEGQGDGSHGSSATQGLKSIAKKDAAVCREQFPKNAQTSVFDKHLNPSQSVVTVQRNKAGQRIFKCDICNKTFKYNSDLSRHRRSHTGEKPYECGPCGRAFTHSSNLILHQRIHTGNKPFKCEECGKTFGLNSYLRLHQRIHTGEKPFGCKECGKAFSRSSSLIQHRIIHTGEKPYKCDECGKAFSQSPQLTQHQRIHTGEKPHGCTWCGKAFSRNASLIQHQRIHTGEKPHKCAQCGKAFSQSSSLFLHHRVHTGEKPYVCGECGRAFGFNSHLTEHVRIHTGEKPYVCGECGKAFSRSSTLMQHRRVHTGEKPYQCAECGKAFIQSSQLTLHQRVHTGEKPYECGLCGKAFSRRSALTQHQRVHMGENPQEFECGPDFVYDSSHLSAGERHGRAFSHSAKLVLQWTIRSDEKSRGCHECGKTYSTSSQSMDYQKSQAGEKPYKCQECGGKAGSGVSPLTPHHVTRVGEKPQLKDGSERYLIQIKKIFQERDF
Protein: SPX domain-containing protein 3 (Protein SPX DOMAIN GENE 3) (AtSPX3) (Q5PP62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a positive role in plant adaptation to phosphate starvation and exerts negative feedback regulation of SPX1.
Interaction partners:
- Protein PHOSPHATE STARVATION RESPONSE 1
- Monogalactosyldiacylglycerol synthase 3, chloroplastic
- Inorganic phosphate transporter 1-4
- Transmembrane protein
- Inorganic phosphate transporter 1-1
- Sulfoquinovosyl transferase SQD2
- Phospholipase D zeta 2
- Phosphate transporter PHO1 homolog 1
- Phosphate transporter PHO1
- SEC12-like protein 1
Sequence:
MKFGKRIKEQIQESLPEWRDKFLRYKELKNLISSPAPVESIFVGLLNAEIDKFNAFFVEQEEDFIIHHKELQYRIQRLVEKCGHNDEMSRENISEIRKDIVNFHGEMVLLVNYSNINYTGLAKILKKYDKRTRGGLRSPFIQKVLHQPFFKTDLVSRLVREWETTMDAVDPVKVAEAEGYERCAAVTSAAAGEGIFRNTVAALLTMKEMRRGSSTYSAFSLPPLNISDSDNVLRSLHLSSPIPIP
Protein: Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) (P27485)
Organism: Sus scrofa (Pig)
Function: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
Subcellular location: Secreted {ECO:0000269|PubMed:2340335, ECO:0000269|PubMed:9757135}.
Interaction partners:
- Transthyretin
- Transthyretin/hydroxyisourate hydrolase domain-containing protein
- Receptor for retinol uptake STRA6
- Vitamin D-binding protein
- Haptoglobin
- Protein AMBP
- Albumin
Sequence:
MEWVWALVLLAALGSAQAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRLQNLDGTCADSYSFVFARDPHGFSPEVQKIVRQRQEELCLARQYRIITHNGYCDGKSERNIL
Protein: adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) (Q583D2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Phosphodiesterase
- Phosphodiesterase
- 3', 5'-cyclic nucleotide phosphodiesterase, putative
Sequence:
MLKLLLLPLLFHTTASAAQINVNIYNMLYSNKISAKIYDPITAGFNASITNGRSHLGANVKVVYVPPMDDSKYADYLEKHMTTHDGEELPVILGPVGDKNTLGLLKYFKEKNVTSFSPFTGSSKVRSWNPNLYFLTASPAAEMLALLRYAITQLRLHRLGFMYLKDVSYGDDEYELAVELTTRMDRKFCGVFALKSQIGKESDDSSFSAEWNKFANTRPQGVIVFGSPIPDTKRFLMKSLDDRRTRGGYLLIPSTLQYVIKNKWAKELGRDRFVPDKIIITGTNPLAKDDGYDAIKRFRGDMAKYLKEKKDILSGTGHWNVNLNVDESNFTEQDTEAELMVSGWIAGEVLKQTVTYTEWLTSRDAFITSLYNQRRYVIDDIVVGDFGGECRGMAGERGASCLCNQGGNVVYMKKMGKDLRLHPMKEGVLTLTSSRCYRDLSQLYAPLSGIMFKLTDDPKALRTAEAIYDGAFYVVGKGQLGHSDRFFLHWLSSKSHDTSTALYDEVEKRVVTAVFGVVDDSLLSTKGMAFIDPITLTPQLSNPRRNVIHLSPTLEQQLFVIVEHIIQNGTGKMHAIVRSGDTRGVRKVLQKTLDIFNASLSSFVASGEGSTLRDKLPTAGEVLVAGLISDDIPIILSHLGKHHNVRIFVPFFDVALLYDELVSAFRDKPFADRLLFATNLPHWGDKNTESDLVREFHRVVQNESKWKPLSLLGYVTARAMINVLQRMGHVTPEELVDAIFSQSVITVDDMRYGPFDDKCTNGASFEEKHCAVNYGATHISVWSMSRVLNPSVSLVVTQVTPAMLKNENSGPTMKTGHIAAIAVSCAVVLALFVTVLVLVIRSSRRNARDNNNAPKEPTDPVTLIFTDIESSTAQWAAHPEQMPDLVATHHRLIRSLITRYECYEVKTVGDSFMIACKSPFAAAQLACDLQRDFLNHDWKTTELDESYREFERKRAEDDSDYTPPTASLDPEVYRQLWNGLRVRVGIHTGLCDIRHDEVTKGYDYYGRTSNMAARTESVGNGGQVLMTLAAYHALSTLEREQINVTPLGDVPLRGVPKPVEMYQLNAVPGRTFAALRLDREAEEEGKESEGIFTDVSDICSSTHELCGSSLHVAQSLDTVFSTLPATQRQRMLTSICERWRVPPPKSVKNRWDKATFRLVIRHIAVRAGPVMSVNIRNAAAAAVCAERKPCPPSHSICDVSQLGRQHPLPSVRIEAPMEVTEYLCMSPTDKFDFSIYSCSTIDINMFNGTLEKFDSREPLFGTSLGDNGKNS
Protein: Neurogenic protein mastermind (P21519)
Organism: Drosophila melanogaster (Fruit fly)
Function: May have a regulatory function possibly in association with the Notch gene product.
Subcellular location: Nucleus {ECO:0000269|PubMed:1701150}. Chromosome {ECO:0000269|PubMed:16508010}.
Interaction partners:
- Suppressor of hairless protein
- Neurogenic locus Notch protein
- histone acetyltransferase
- histone acetyltransferase
- Protein deltex
Sequence:
MDAGGLPVFQSASQAAAVAQQQQQQQQQQQQHLNLQLHQQHLGLHLQQQQQLQLQQQQHNAQAQQQQIQVQQQQQQQQQQQQQQHSPYNANLGATGGIAGITGGNGAGGPTNPGAVPTAPGDTMPTKRMPVVDRLRRRMENYRRRQTDCVPRYEQAFNTVCEQQNQETTVLQKRFLESKNKRAAKKTDKKLPDPSQQHQQQQHQQQQQHQQHQQHQQAQTMLAGQLQSSVHVQQKFLKRPAEDVDNGPDSFEPPHKLPNNNNNSNSNNNNGNANANNGGNGSNTGNNTNNNGNSTNNNGGSNNNGSENLTKFSVEIVQQLEFTTSAANSQPQQISTNVTVKALTNTSVKSEPGVGGGGGGGGGGGSGNNNNNGGGGGGGNGNNNNNGGDHHQQQHQQQQQQQGGGLGGLGNNGRGGGPGGMATGPGGVAGGLGGMGMPPNMMSAQQKSALGNLANLVECKREPDHDFPDLGSLDKDGGGGQFPGFPDLLGDDNSENNDTFKDLINNLQDFNPSFLDGFDEKPLLDIKTEDGIKVEPPNAQDLINSLNVKSEGGLGHGFGGFGLGLDNPGMKMRGGNPGNQGGFPNGPNGGTGGAPNAGGNGGNSGNLMSEHPLAAQTLKQMAEQHQHKNAMGGMGGFPRPPHGMNPQQQQQQQQQQQQQQAQQQHGQMMGQGQPGRYNDYGGGFPNDFGLGPNGPQQQQQAQQQQPQQQHLPPQFHQQKGPGPGAGMNVQQNFLDIKQELFYSSQNDFDLKRLQQQQAMQQQQQQQHHQQQQQQQQPKMGGVPNFNKQQQQQQVPQQQLQQQQQQQQQQQQQQQQQYSPFSNQNPNAAANFLNCPPRGGPNGNQQPGNLAQQQQQPGAGPQQQQQRGNAANGQQNNPNAGPGGNTPNAPQQQQQQSTTTTLQMKQTQQLHISQQGGGAHGIQVSAGQHLHLSGDMKSNVSVAAQQGVFFSQQQAQQQQQQQQPGGTNGPNPQQQQQQPHGGNAGGGVGVGVGVGVGNGGPNPGQQQQQPNQNMSNANVPSDGFSLSQSQSMNFNQQQQQQAAAQQQQVQPNMRQRQTQAQAAAAAAAAAAQAQAAANASGPNVPLMQQPQVGVGVGVGVGVGVGVGNGGVVGGPGSGGPNNGAMNQMGGPMGGMPGMQMGGPMNPMQMNPNAAGPTAQQMMMGSGAGGPGQVPGPGQGPNPNQAKFLQQQQMMRAQAMQQQQQHMSGARPPPPEYNATKAQLMQAQMMQQTVGGGGVGVGGVGVGVGVGGVGGANGGRFPNSAAQAAAMRRMTQQPIPPSGPMMRPQHAMYMQQHGGAGGGPRTGMGVPYGGGAGGPMGGPQQQQRPPNVQVTPDGMPMGSQQEWRHMMMTQQQTQMGFGGPGPGGPMRQGPGGFNGGNFMPNGAPNGAAGSGPNAGGMMSGPNVPQMQLTPAQMQQQLMRQQQQQQQQQQQHMGPGAANNMQMQQLLQQQQSGGGGNMMASQMQMTSMHMTQTQQQITMQQQQQFVQSTTTTTHQQQQMMQMGPGGGGGGGGPGSANNNNGGGGGGAAGGGNSASTIASASSISQTINSVVANSNDFGLEFLDNLPVDSNFSTQDLINSLDNDNFNLQDFNMP
Protein: Putative iroquois-class homeodomain protein irx-1 (Q93348)
Organism: Caenorhabditis elegans
Function: Transcription factor (By similarity). Required for D-type inhibitory GABAergic motor neuron synaptic remodeling, acting via degenerin unc-8-dependent and -independent mechanisms. Regulates expression of genes involved in synaptic remodeling, including negative modulation of immunoglobulin domain-containing protein oig-1 and positive modulation of unc-8.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:22031882}.
Interaction partners:
- Nuclear hormone receptor unc-55
- Myelin regulatory factor homolog 2
- Transthyretin-like family protein
- Serum response factor homolog
- Activin_recp domain-containing protein
- Immunoglobulin domain-containing protein oig-1
- Transcription factor sox-3
- Sex-determining region Y protein
Sequence:
MIPIANQVKMEEPTTPQTTTPAPPTSAPDALRGILPPNLLGQFHFHPAMAQVLAAQAQAAAAAQQATLAGFPGVPMFPHGIPADLKPEMLLGGGPGPMPMFFSDAHRLYHPYGLDGIKKRNATREATAPLKDWLHSHRKNPYPSKADKVMLAVGTGMTLTQVSTWFANARRRLKKENKMTWSPQNRRGDGCDDDEDDDDDDMNRPSSSTSINSERKGESLFGKPHLASPTPSGGSGGSDELTTPKKELVSPIPNDDSESPKRKPKMWSIADVTSDDDSSKKDSPPSSDENLLTGSLFQNAMKKQMEVMARLDPTLFRHTMHPFMFQLLAQQAAQGQQLALLAPQTTPPNEAGLNSQAETSTPSPASSPTSSPRSHQE
Protein: Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) (Q8WUU4)
Organism: Homo sapiens (Human)
Function: May be a transcriptional corepressor with KLF4.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:E9Q6W4}.
Interaction partners:
- Myeloperoxidase
Sequence:
MSRRKAGSAPRRVEPAPAANPDDEMEMQDLVIELKPEPDAQPQQAPRLGPFSPKEVSSAGRFGGEPHHSPGPMPAGAALLALGPRNPWTLWTPLTPNYPDRQPWTDKHPDLLTCGRCLQTFPLEAITAFMDHKKLGCQLFRGPSRGQGSEREELKALSCLRCGKQFTVAWKLLRHAQWDHGLSIYQTESEAPEAPLLGLAEVAAAVSAVVGPAAEAKSPRASGSGLTRRSPTCPVCKKTLSSFSNLKVHMRSHTGERPYACDQCPYACAQSSKLNRHKKTHRQVPPQSPLMADTSQEQASAAPPEPAVHAAAPTSTLPCSGGEGAGAAATAGVQEPGAPGSGAQAGPGGDTWGAITTEQRTDPANSQKASPKKMPKSGGKSRGPGGSCEFCGKHFTNSSNLTVHRRSHTGERPYTCEFCNYACAQSSKLNRHRRMHGMTPGSTRFECPHCHVPFGLRATLDKHLRQKHPEAAGEA
Protein: Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] (Q63692)
Organism: Rattus norvegicus (Rat)
Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q16543}.
Interaction partners:
- Heat shock protein HSP 90-beta
- Cyclin-dependent kinase 4
- RAC-alpha serine/threonine-protein kinase
- Endoplasmin
- Stress-induced-phosphoprotein 1
- Heat shock 70 kDa protein 4
- Serine/threonine-protein phosphatase 5
- Heat shock protein HSP 90-alpha
- RAC-gamma serine/threonine-protein kinase
- RAC-beta serine/threonine-protein kinase
Sequence:
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADQQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDISA
Protein: Symplekin C-terminal domain-containing protein (Q57V70)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEAFIEAARQAVTVAAVDFSPVQQLAEDAAKGVADGEALRETITTLVDTYSAADSSQVVLQCSLMKAIGSILCATASNVGGGNCQLVVDDYILLALFFNEISTVGDVQLFSLLTEAVTALFRQTAAVAFKSVLPPSSNETEDCSSITSLRGELQSLRLVMAKRLVGPSNASEFVSKQHQRHDTAMQLKVIDCLRVLLLSLLEVSNSEDATLAAVKEMQKDGTGNEAALQAARQVVEGLLLPLSTAVDALRPHVTNNSSGKGRLLVTPQPNGAHGTAVSPLVLVSTFRVVEELLWHCAGRGTDDSIAVVGRFAANRLLTAVQQYLVLQQQKSVESTGTESQEKPAAAFDVLRAAGPQRAIRRLLSVVHRQLPVFPSIESAVTAAIGVFGGQLDVDDPLKLTNLQQDGVGAENRCNNATDVSGDNRICAAKWEEAPSSSATSRLRECEQILPAPSSDAVVNEGAAADFDDPTLMEDGADGGPRETLLKSTVGPLPANALVEMVFLSISRLDIMNEQGIQLLHMQGLQQQQYEAVRRAQRAELQRLRRIEQQGVENIPVGRLLEHLKESTAMYAAGAQLLSNESGLATMQRAALFSLLDAYDLLVDAQEGRVREAQALIARTIAQMPSSMMDSALDAVCARLKKELAAASSFQKTRGGSPVAKVPPLTSAYQLALQVLFMLYSAQAPVHEHDGKALMFAVSPSSAFANMGGEMQLQSRAVLTIDTENPVDWLQAPDMQSSLTDRKRPRDDGSSFGGNDLDSFHRERVSGSEEAQSATDGPSRFFREDSIQNPCVYSHFLCRMMEVLTEGEMPVLLLDLLLQCPRITRYVWHCLHKHYCLSPEKARCLLGMWLLKSVAARRAVCRRYALNSLLYMTTSRSEYPRRLAVKQLGALLASSVGLDGRRVIDDNVETLLVRHAKRQIAAIPVTRLPTAVTSSGSAVAKQEEGETTMTGGDAAETRAKELQKLTEALDRHLGPFLMLCARQPRELIPALLDVFKECVERQNTAMVQLLADHVDVRRMCQRLFQTDALSFMSNVMPYLRRYSNSATMLVQRILWAVSAELRSMGKGGEVSAADLEGIAAALLGHARVMYENSEIPFVYHSALASNGEPADVVSVQESPASLHDVRFIAPFMSLIPMEELKRTYLRSFLHFVEQQLQQRAEETMDNDTAPESMRMSEEEMSQLIRDVAQEVLVRSPVQFSDGSPRGVSRVDLLVYLHHATRGVRDGDAYQSKAHQSSPHSTVVETPMRTHAETRGILSSSGPQSPDGSVVGNNAKARTAEGETSLIAENLPLSALTTKEVICVLLKLRRTFDESTTEYLYGPAEIKGAVRQLMKNTGATKVPSQLMATLIFACGLHPPRAAVDLVRFVHQEVLLPLAKDGTWEKDVQLWRGVLLFAEMHYRECSSFLVNLPDQVLIEALRVRPQLCEYFREEHGNNAYFGHILGSL
Protein: Peroxisomal targeting signal 1 receptor (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) (B4E0T2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Peroxisome matrix {ECO:0000256|ARBA:ARBA00004253}.
Interaction partners:
Sequence:
MLLCRAHRVLGLRGARELAVTMAMRELVEAECGGANPLMKLAGHFTQDKALRQEGLRPGPWPPGAPASEAASKPLGVASEDELVAEFLQDQNAPLVSRAPQTFKMDDLLAEMQQIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTATDRWYDEYHPEEDLQHTASDFVAKVDDPKLANSEFLKFVRQIGEGQVSLESGAGSGRAQAEQWAAEFIQQQGTSDAWVDQFTRPVNTSALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSATYDKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSTLLTMFGLPQ
Protein: Protein YOP1 homolog (PbYOP1) (A0A509ADH4)
Organism: Plasmodium berghei (strain Anka)
Function: Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the digestive (food) vacuole. Induces high curvature in membranes and causes membrane tubule formation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:32432369}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein SEY1 homolog
Sequence:
MRMSKLYKNKEKENEKPSNEPPIKQDSLKRMSSKFLGNSLNSFDLSGKLEQVDEYLKKYPFIIEFGYKLGIKPSYIVVFGGSALFISLVLGWGAALICNLVGFAYPAYQSFKAVESQGHAETKLWLTYWVVFSLFFFIEYLIDIILFWIPFYYVIKLLFLLYLYMPQVRGAETVYNYIIRPILLKHEKTIDDTVHKISQTATNHLNQFTGNIAEKLVQEGVRRRNV