wanglab/gogpt-training-data huggingface dataset:
Protein: Vacuolar protein sorting-associated protein 16 homolog (Q11182)
Organism: Caenorhabditis elegans
Function: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine. The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for recruitment of vps-33.1 to the HOPS complex (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with vps-33.1 but not vps-33.2 (By similarity).
Subcellular location: Late endosome membrane {ECO:0000250|UniProtKB:Q9H269}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H269}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H269}. Lysosome membrane {ECO:0000250|UniProtKB:Q9H269}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H269}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H269}. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q9H269}.
Interaction partners:
- Vacuolar protein sorting-associated protein 33A
- Vps8 domain-containing protein
- Vacuolar protein sorting-associated protein 39 homolog
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar fusion protein CCZ1 homolog
- V-SNARE coiled-coil homology domain-containing protein
- Ras-related protein Rab-7a
- Vacuolar protein sorting-associated protein 33B
Sequence:
MGESHAPSKPKLDGELCLRPSSSVFLGDQQLYFTQEYLRTNSLNLKYVVYFTACQFSGPIAVAYSPRPASWYIWIRTISGRILKRDMAFNEPVFMEWTRAHCLLVLNKAGRAHIFSSLGEKISEVIFDSQMSDVHECRTFATSRGDSGIAVMDVDGQVSVVNSVSEPVIWSMKPPYSEMPTAWTAFQPHSQLTHILLIFEAVFLMGCQGESLREQSHAASWVDSNTKYVKCVVDDARSRIAMMTESGKIQIVSIDLSTCFCTVEITDHDIAKCINFGWVGNSAVFVQMSPSLIVFVNVSARRKPGDEVQIYEKMTANAKISIEPDGIRLFESTQVEFVEAASREKIAVLNRNPNEDGAHLYKAAQEMSQGTGHNSFAASTVIQDLYKAIDDCISTACDTWQPEEQKLLLKAARFGMAYTNTTPDTTKLMRAIKEIRVLNELRMVRTGIPLTHRQFRAIGETCVINRLIDMGSYSVAIKVAQWLGGETSENVDRVLLEWVRRSISKVSKSNMKMDQPALEALDEKISAKLLQFPHVSIADAARRAIEAKLPELARLFIRRETDDANHVAVLLQLNDVSAALQKASASQRPQLIHQVVRHLMNSESRSSYELAISRIPLAQCLYQDLVRQEGETRGASSRQMLALLEQASDFERQTLFHFDVAETERNPDERLNALRRAKDAAKSMGDKAIEEILNDVSAFAPLQIQRGQADMSVRDTVIEMAHDTAKVAQLKQQARLTDKQVLLWTIEGLAKKGKMEQLFDLAQKRSPIGYAPFVKACVRYKRLDEIKKYFAKVNGYPDLVAAHLAMKNYVEAAKLAYDRRDRDVLHAVHMKSHEDPTQCPRVGQFLRSLDQN
Protein: Golgi pH regulator A (Protein GPR89A) (Putative MAPK-activating protein PM01) (Putative NF-kappa-B-activating protein 90) (B7ZAQ6)
Organism: Homo sapiens (Human)
Function: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18794847}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cancer/testis antigen 47A
- Cancer/testis antigen family 47 member B1
Sequence:
MSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEIRQYVVQVIFSVTFAFSCTMFELIIFEILGVLNSSSRYFHWKMNLCVILLILVFMVPFYIGYFIVSNIRLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAMARRTMFQKGEVHNKPSGFWGMIKSVTTSASGSENLTLIQQEVDALEELSRQLFLETADLYATKERIEYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGKTDPVTRGIEITVNYLGIQFDVKFWSQHISFILVGIIIVTSIRGLLITLTKFFYAISSSKSSNVIVLLLAQIMGMYFVSSVLLIRMSMPLEYRTIITEVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHKQAPEKQMAP
Protein: At4g33560 (Wound-responsive family protein) (O81873)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Plant cysteine oxidase 1
- Anaerobic nitrite reductase AHB1
- tRNA-specific adenosine deaminase TAD3
Sequence:
MNAGKQASWAVATAIAAVEVLKDQGVARWNYLFRLLHKEAMARVRTITVPSRPSPPTSSSSATSIRSKPLSTTPFETSFEKAMGLSCFGPTTVRF
Protein: Zinc finger E-box binding homeobox 2 (A0JP08)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM
Protein: Acylsugar acyltransferase 3 (Sl-ASAT3) (EC 2.3.1.-) (K4D9Y4)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Catalyzes the transfer of short (four to five carbons) branched acyl chains to the furanose ring of di-acylsucrose acceptors to produce tri-acylsucroses such as S3:15 (5,5,5), S4:17 (2,5,5,5) and S4:24 (2,5,5,12) acylsucroses.
Interaction partners:
- Isopropylmalate synthase
- 2-isopropylmalate synthase
Sequence:
MASSTIISRKMIKLLSPTPSSLRCHKLSFMDHINFPLHSPYAFFYPKIPQNYSNKISQVLENSLSKVLSFYYPLAGKINNNYTYVDCNDTGAEYLNVRIDCPMSQILNHPYNDVVDVVFPQDLPWSSSSLTRSPLVVQLSHFDCGGVAVSACTSHTIFDGYCLSKFINDWASTARNMEFKPSPQFNASTFFPLPSETNLSSTLPATRPSQRHVSRMYNFSSSNLTRLKDIVTKESHVKNPTRVEVASALVHKCGVTMSMESSGMFKPTLMSHAMNLRPPIPLNTMGNATCIILTTAMTEDEVKLPNFVAKLQKDKQQLRDKLKDMKEDRMPLYTLELGKNAMNIIEKDTHDVYLCSGMTNTGLHKIDFGWGEPVRVTLATHPNKNNFIFMDEQSGDGLNVLITLTKDDMLKFQSNKELLEFASPVVESTK
Protein: Stearoyl-[acyl-carrier-protein] 9-desaturase 1, chloroplastic (Stearoyl-ACP desaturase 1) (EC 1.14.19.2) (Acyl-[acyl-carrier-protein] desaturase 1) (Q9LF04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Oleoyl-acyl carrier protein thioesterase 1, chloroplastic
- Oleoyl-acyl carrier protein thioesterase 2, chloroplastic
- Palmitoyl-acyl carrier protein thioesterase, chloroplastic
- Enoyl-[acyl-carrier-protein] reductase, chloroplastic
- Enoyl-[acyl-carrier-protein] reductase, mitochondrial
- Acyl carrier protein 5
- 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic
- Delta
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- EMBRYO DEFECTIVE 3147
Sequence:
MVMAMDRIALFSSSSSVYHHGSSHSHGSKSSRVFTIRSDSTAVGRKLYIPPREVHLQVKYSMPPQKLEIFKSLEGWANDNLLAYLKPVEKSWQPTDFLPEPESEGFYDQVKELRERCKELSDDYLIVLVGDMITEEALPTYQTMINTLDGVRDETGASPTPWAVWTRAWTAEENRHGDLLNKYLYLSGRVDMRQIEKTIQYLIGSGMDPKTENNPYLGFIYTSFQERATFISHGNTARLAKDLGDLTLGKICGTIAADERRHEHAYTKIVEKLFEIDPDTTVVGFADMMRKKISMPAHLMYDGRDDNLFDHFSSVAQRLGVYTAKDYADILQHLVERWNVEKLSDLSSEGNRAQDYLCGLPARIRKLEERAQGRTKEAAKNIPFSWIFGREVRA
Protein: Prolargin (Proline and arginine rich end leucine rich repeat protein) (F1S6B4)
Organism: Sus scrofa (Pig)
Interaction partners:
- Aggrecan core protein
- Dermatopontin
- Fibromodulin
- Osteomodulin
- Mimecan
- Lumican
Sequence:
MRSSLCWLLPLLLILASAAQGQPTRRPRPRPRPRPRPRPRPTPSFPDPHEPSEPTDLPPPLPPGPPSVFPDCPRECYCPSDFPSALYCDSRNLRKVPVIPSRIHYLYLQNNFITELPVESFKNATGLRWINLDNNRIRKVDQRVLEKLPSLVFLYMEKNQLEEVPSALPRNLEQLRLSQNQISRIPPGVFSKLENLLLLDLQHNKLSDGVFKPDTFQGLKNLMQLNLAHNILRKMPPKVPTAIHQLYLDSNKIETIPNGYFKGFPNLAFIRLNYNKLSDRGLPKNSFNISNLLVLHLSHNKISNVPAINNKLEHLYLNNNSIEKINGTQICPTDLVAFHDFSSDLENVPHLRYLRLDGNYLKPPIPLDLMMCFRLLQSVVI
Protein: Rh blood group antigen (O75104)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
FAAYFGLSVAWCLPKPLPEGTEDKDQTATIPSLSAMLGALFLWMFWPSVNSALLRSPIQRKNAVFNTYYAVAVSVVTAISGSSLAHPQGKISK
Protein: Large ribosomal subunit protein eL31 (60S ribosomal protein L31) (P62899)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}.
Interaction partners:
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein P2
- Large ribosomal subunit protein uL11
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein uL10
Sequence:
MAPAKKGGEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKNLQTVNVDEN
Protein: Alpha-amylase (EC 3.2.1.1) (A0P8X0)
Organism: Niallia circulans (Bacillus circulans)
Function: Acts on maltooligosaccharides that have a degree of polymerization (DP) of 4 or more, amylose, and soluble or raw starch to produce glucose and maltooligosaccharides up to DP5 by a hydrolysis reaction. Also acts on maltooligosyl trehaloses that have DP5 or more to produce trehalose as the major hydrolysis product.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MTRKTRYLHQITTLILGGLLIVPAAAPPVSADIAATHVYHNHMPNFWAYYDLNTYNSTPVGSPIRYTYDGEVIQLKQNPPAGYPYYLPNGSPMPHDDLVSYYSHHAKTGAYLTWPWSVANTLHSSHPQAQMHVTMSGSVVNNVNSIIQQGNVSGYNNPAWGTPWKNAVTQLKTAGGDNRLDLIHFSGHHSMGPLVGNDYLLKDMIYHGATMAQPYFLGSSYKSSKGFFPTELGFSERIIPVLNKLGIQWSVIGNNHFSRTLKDYPLLDSPGTDTMISPPNRSDLQNVSTAGAWVNEPMFNEQQVVYNKYPFASTAHWVRYVDPATGAESRVVGVPVAQAQSWEEGYLGQVKADALKPYENLVAQKQIFVVAHDGDNSSGRAGSEETWRNAGNVTYADSGVTGMGIDEYLRSNTPAAADVVHVQDGSWIDTRDSSSDPAWYHWHLPFGIWKGQFAAFNQVNGTAYAPKKNLAGVEEGMTVSFEKGYHYLERNFALLQASLNYAKTAEQIWLEEHPNYWKPANPLDREVTYEGNQLNPWMLSYPVKGNPANDYAGGANPAELAWYFLLPAMDSGFGYYDENVDDSVKPALSFNQSLYFSKPYVSQKLAKDKTGPSVWWPQRYPYNPGSANVSKAEGWTLQHYNNAFAIYTYAFDTSGISEIKVKVRAHRDKTADAADNTFKVYDPAGLAAAGIANIDPAKVGAWTEYPMNVRDLSADINGVDWQPSSMTIMQKVPATDIGNLYFSYISDYRDQLLDYFIEAKDAKGNVTQSDIQQVYVGAGKYKLANGKYTESMQGTIEGTHPFITDVPAVPDTEAPAVPANLQATVMNASSVGLSWNAATDNIRVTGYEIYRNGVRIGTTPSTSYTDSGLSASTAYEYRVKAYDASGNLSGFSAAATATTPAGNHVTVYYKQGYSTPYIHYRPAGGTWTTAPGVAIPAAEVAGYNKITINIGAATQLEACFNNGSGTWDSNGGSNYLFGTGTWTYTPTGKIQAGAPVAPSATPTVAPTATPTPKPSVTPTVTPITTPTVAPTLSPTPTVAPTVKPSATPIATPTVTPTVSPTATPTVVPTIAPTATPTTSPSATPVPTATPAGNSATIYYKNTAFSNSYIHYKLDGATAWTTSPGVQMQASTFSGYKAITIPLGSATGLTAAFNNGSGIWDNNGGSNYHFGTGSSSLTGGNLITGEPQADSVTFRVSVPGSTPANAPVYLTGSFNSWNAADPAYLLTRGSDGIYSITLNLPAGSAVTYKLTRGSWATVETASSGADITNRTLTPAGGAQTVTLTVQRWKDQ
Protein: Arylesterase (A-esterase) (EC 3.1.1.2) (Paraoxonase) (EC 3.1.8.1) (B5BLW5)
Organism: Saccharolobus solfataricus (Sulfolobus solfataricus)
Function: Has a broad substrate specificity. Hydrolyzes various p-nitrophenyl phosphates, aromatic esters and p-nitrophenyl fatty acids in vitro. Most active against paraoxon, phenyl acetate and p-nitrophenyl caproate (C6), respectively. Has also tributyrinase activity, but shows no hydrolytic activity toward other triacylglycerols including tricaprylin, trimyristin, tripalmitin or triolein in vitro.
Interaction partners:
Sequence:
MPLDPEVRNFLQVYYKANIIDFTKYQFQEIRQKVNELLAKAVPKDPVGETRDMKIKLEDYELPIRIYSPIKRTNNGLVMHFHGGAWILGSIETEDAISRILSNSCECTVISVDYRLAPEYKFPTAVYDCFNAIVWARDNAGELGIDKDKIATFGISAGGNLVAATSLLARDNKLKLTAQVPVVPFVYLDLASKSMNRYRKGYFLDINLPVDYGVKMYIRDEKDLYNPLFSPLIAEDLSNLPQAIVVTAEYDPLRDQGEAYAYRLMESGVPTLSFRVNGNVHAFLGSPRTSRQVTVMIGALLKDIFK
Protein: Peptide ABC transporter, permease protein (O69632)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}.
Interaction partners:
Sequence:
MIAAALILLILVVAAFPSLFTAADPTYADPSQSMLAPSAAHWFGTDLQGHDIYSRTVYGARASVTVGLGATLAVFVVGGALGALAGFYGSWIDAVVSRVTDVFLGLPLLLAAIVLMQVMHHRTVWTVIAILALFGWPQVARIARGAVLEVRASDYVLAAKALGLNRFQILLRHALPNAVGPVIAVATVALGIFIVTEATLSYLGVGLPTSVVSWGGDINVAQTRLRSGSPILFYPAGALAITVLAFMMMGDALRDALDPASRAWRA
Protein: Pleckstrin homology domain containing, family A member 5 (A0A0N4SV65)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
QKGRGLEEEPRGVISYQTLPRNMPSHRAQILARCPEGYRTLPRNSKTRPESICSVTSSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPRHGCLSSPKAMVQVSDQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEVTSPIQRGDVTIDRRHRPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRTLSQDECRGTLYKYRPEEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRDQMQGQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETGLAGSKPFSSVKYKSEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSETEAPVVKGSHFPVGVPLRTKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLERIRRHQQACLREKKKGLSVLGASDPSDVRDSPLRLTQTLRRDDNVKELDTVHRENDVKPDYETPAAQCAHLEDAEPQNADIGRKLKRSEMLYTPEPNGMASEEVTEKERQKEQVHADGSCSPQEETAMTEHQMEGPPEEAESLHEEEETLASCEPAPEIPRENQTTAALASVESSQS
Protein: Centrosomal protein 39 kDa (Q54DL5)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MNINNNNNGSDSTNNNGNNNNINNDNTNNNNNNFQETSASNFINNPTSMRFVLRSKSPSSKQNESRPYRIDQNEIDDNSYNNNNNNNNNNNSGISNSNNSSNNGNNSNIDNSSNNRHPIFSLANQQTTPQQQQKQQQQQQQSYNESGEDFLKYIDNKLEQLEKESQFQASFNYNYNNNNLNFNSPPKNNGKHINSTPQQQQQQQQQQQQQKQRQQNSNNNNNNYNNQQQQQQQQQGQGQPLNSTRRLPSNTMYQSPIKPNETNNTTTSSPNNHIKTPLNQQQRNQTIIANLNFVNESIGREIEELERVLNWHTINSTNERDIASIKYQIQLKYNQIQKLNEIGSLI
Protein: Synaptobrevin-1 (Synaptobrevin-related protein 1) (O02495)
Organism: Caenorhabditis elegans
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:10476681, ECO:0000269|PubMed:15254012, ECO:0000269|PubMed:16844789}; Single-pass type IV membrane protein {ECO:0000269|PubMed:10476681, ECO:0000269|PubMed:15254012, ECO:0000269|PubMed:16844789}. Cell membrane {ECO:0000269|PubMed:10476681, ECO:0000269|PubMed:15254012, ECO:0000269|PubMed:16844789}. Synapse, synaptosome. Note=Observed in discrete synaptic vesicle puncta along the ventral cord. Functional unc-104, a kinesin-like protein, is required for localization. The two pools of synaptobrevin are recycled by clatherin- and dynamin- dependent endocytosis. AP180-like adapter protein, unc-11, is thought to act as a molecular chaperone. {ECO:0000250|UniProtKB:P63045, ECO:0000269|PubMed:10476681, ECO:0000269|PubMed:15254012, ECO:0000269|PubMed:16844789}.
Interaction partners:
- Syntaxin-1A homolog
- Synaptosomal-associated protein
- Putative syntaxin-2
- Putative syntaxin-4
- Synaptotagmin-1
- Alpha-soluble NSF attachment protein
- Ras-related protein Rab-3
- t-SNARE coiled-coil homology domain-containing protein
- Acetylcholine regulator unc-18
- Rab-3-interacting molecule unc-10
Sequence:
MDAQGDAGAQGGSQGGPRPSNKRLQQTQAQVDEVVGIMKVNVEKVLERDQKLSQLDDRADALQEGASQFEKSAATLKRKYWWKNIKMMIIMCAIVVILIIIIVLWAGGK
Protein: Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP) (Q80VJ2)
Organism: Mus musculus (Mouse)
Function: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9HD15}. Cytoplasm {ECO:0000250|UniProtKB:Q9HD15}.
Interaction partners:
- Retinoic acid receptor gamma
- Protein BRICK1
- Abl interactor 1
- Cytoplasmic FMR1-interacting protein 1
- Abl interactor 2
- Actin-binding protein WASF1
- ABI gene family member 3
- Actin-binding protein WASF2
- Cytoplasmic FMR1-interacting protein 2
- Nck-associated protein 1
Sequence:
MAELYVKPGNKERGWNDPPQFSYGLQTQTGGPKRTPLTKRVAAPQDGSPRAPETSGPPPVDHPPPSSKASRPPPMGSCPATGVEPPSSPVIESETLIEDVLRPLEQALEDCHGHTKKQVCDDISRRLALLREQWAGGKLSIPVKKRMALLVQELLHHQWDAADDIHRSLMVDHVTEVSQWMVGVKRLIAEKKSLSSEETKEEKFTVEPENQTIPGFQQPS
Protein: Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (Preconditioning-inducible gene 1 protein) (Q6AZ50)
Organism: Rattus norvegicus (Rat)
Function: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9NT62}.
Interaction partners:
- Ubiquitin-like protein ATG12
- Ubiquitin-like modifier-activating enzyme ATG7
- Autophagy protein 5
- Autophagy-related protein 16-1
- Gamma-aminobutyric acid receptor-associated protein
- Gamma-aminobutyric acid receptor-associated protein-like 1
- Microtubule-associated protein 1 light chain 3 alpha
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Protein Atg16l2
- CASP8 and FADD-like apoptosis regulator
Sequence:
MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAYLPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLESKDSIKLQDCSVLCDEEEEEEEGEAADMEEYEESGLLETDEATLDTRRIVEACKAKADAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKKTVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDYTRHFTM
Protein: Uncharacterized protein (Q57YE0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- NAD-dependent protein deacylase SIR2rp3
- Histone H3, putative
- Histone H3 variant
- C2H2-type domain-containing protein
- NAD-dependent protein deacetylase SIR2rp1
- GOLD domain-containing protein
- 14-3-3-like protein, putative
- 14-3-3-like protein, putative
- Histone H4
- Histone H4
Sequence:
MTEFNYDTMFLCTSDDRDNLDTITESLTRQMNDDDDDDDNIMVMRKARSGAAAPASTAVVPEGAANHLHTALDTEAMLRSKDSKSLLVSQESGHSTFETSRTLDQVDSKSLLSAYSRFSQPLSSSEPPTPGVMSVTEPSATSPPALVSANPVAGYDQPPAGTGQRTLPSYNPQEDCPPPYEWVGERSKHAQMPVAQQMPLANPQVARASAGVQSIVQMPGGVYSMGTQIVPSSLLSVSMQKRPAVVPQQQQTALSGAFTPAVGLNQMVQSFAAPPSPMATSAPGATQRLQATPSLASGTSAPPPGYVQFLTPVQNVNGSTGCQMVMVPTQQISQVGSVQSPIGQDLRDFSQQQQQQQVMQYVWKAPPQQLQPQQLAQPQQFVTQQYSNISRPPQGYAIVQPGGQQSCMMAISTNQLQQVQPQAYIQQQLQPNSTRQVFITNQHPQQQLFTTPVMPTTLPMGCRFN
Protein: Type VI collagen alpha-3 chain (Q1T7A5)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
GGRHANTKVGLEHLRLNQFVPEAGSRLEQRVPQIAFVITGGKSVEDAQEASLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDISKACNLEVILGFDGSRDQNIFVAQKGFESKVDTILNRISQMQRISCSGTQMPTVRVSVVATTPAGPVEAFDFAEYQPEMFEKILGMRTQHPYVLTADTLKLYQNKFRQGSPGSVKVVIHFTDGADGDLADLQRASEALRQEGVQALILVGLERVPNLEQLMQLEFGRGFTYNRPLRLNLLDLDYELAEQLDNIA
Protein: DEAH-box helicase 35 (A2ACP9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAAPLGPVKFWKPGTEGPGVSISEERQSVTENSGTTIIYNPYAALSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTKFRDFFNQNETSDPARDTSVTLTVEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRV
Protein: NCK adaptor protein 1 isoform 1 (A0A0S2Z4Y3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKHLS
Protein: Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.4.19.12) (Deubiquitinating enzyme 26) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Q9BXU7)
Organism: Homo sapiens (Human)
Function: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:20501646}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:34202084}.
Interaction partners:
- Androgen receptor
Sequence:
MAALFLRGFVQIGNCKTGISKSKEAFIEAVERKKKDRLVLYFKSGKYSTFRLSDNIQNVVLKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFLDRVHQNEVQPPVRPGKGGSVFSSTTQKEINKTSFHKVDEKSSSKSFEIAKGSGTGVLQRMPLLTSKLTLTCGELSENQHKKRKRMLSSSSEMNEEFLKENNSVEYKKSKADCSRCVSYNREKQLKLKELEENKKLECESSCIMNATGNPYLDDIGLLQALTEKMVLVFLLQQGYSDGYTKWDKLKLFFELFPEKICHGLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIKAHPSSIQSTFDLFFGAEELEYKCAKCEHKTSVGVHSFSRLPRILIVHLKRYSLNEFCALKKNDQEVIISKYLKVSSHCNEGTRPPLPLSEDGEITDFQLLKVIRKMTSGNISVSWPATKESKDILAPHIGSDKESEQKKGQTVFKGASRRQQQKYLGKNSKPNELESVYSGDRAFIEKEPLAHLMTYLEDTSLCQFHKAGGKPASSPGTPLSKVDFQTVPENPKRKKYVKTSKFVAFDRIINPTKDLYEDKNIRIPERFQKVSEQTQQCDGMRICEQAPQQALPQSFPKPGTQGHTKNLLRPTKLNLQKSNRNSLLALGSNKNPRNKDILDKIKSKAKETKRNDDKGDHTYRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFYMHNEIFEEMLKREENAQLNSKEVEETLQKE
Protein: HMG box-containing protein C19G7.04 (O42953)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MQVSNSMSLNDEEDDIEFINYIPLLASPINSSTCSTSIHDKCPFKQHISENGQNFGSAISSNISQRNFKTLRASHLSQYRDCNRENNTEDKNVISTGIAVNEKYQSVLKLKEKAPQISSAAKRKSFIKERGMLAKCFLARLEDEVFQGRLTSSLEKKEIGIVWSKSFSTTAGRANLKRNNKDAPLGKKTYAYIELSDKVIVTKERLYNTLAHEVCHLACWIIDNEMQNPHGACFKAWGKRIMNNMPYIEITSKHNYDIDFKYKWLCINEKCNKLYGRHSKSINPQKQVCRLCKSQIKQICPKIKQPNAFQIFLKENSKRLRKLHPHITHKELMKKLSDEYHRTKDAKQNVSKSVSLISSSDL