wanglab/gogpt-training-data huggingface dataset:
Protein: MORF4 family-associated protein 1 (Protein associated with MRG of 14 kDa) (Q9CQL7)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y605}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9Y605}. Note=Colocalizes with MORF4L1 to cell nuclei. {ECO:0000250|UniProtKB:Q9Y605}.
Interaction partners:
- Mortality factor 4-like protein 1
- Mortality factor 4-like protein 2
- MRG/MORF4L-binding protein
- 14-3-3 protein epsilon
Sequence:
MRPLDAVELAEPEEVEVLEPEEDFEQFLLPVIHEMREDIASLTRERGRAPARNRGKLWEMDNMLIQIKTQVEASEESALNHLQGAGGAEPRGPRAEKADEKAQEMAKMAEMLVQLVRRIEKSESS
Protein: Ras-related protein rapC (EC 3.6.5.2) (Q55BW0)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Frizzled/smoothened-like sans CRD protein F
- Protein spalten
- Uncharacterized protein
- Rac guanine nucleotide exchange factor B
Sequence:
MQTYKVVVLGASGTGKTSLTVRFVNGDFVETYDPTIEDLYRKVIETNKGEHIMLEIMDTSGTERYLAMRDLYIRNAQAFVLVYSITSRVSLLELENIKNYICQVKDRPISQIPMVVLGNKCDLEDTRVVFPEEVEALTKKWGIEDFLETSAKIDMNIQSAYDCLTLQLMSKQSFLNGSSNGKDKKDKKEKKTHKKDSGSNNSSINSSSSSLSVSGGSNLSISSSCSSSSFSNLSNSTSSTSVNNLNQSQTNAPIRTKSKRSLKSAKVDKNPKGKCLIM
Protein: Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10) (Q9NQT5)
Organism: Homo sapiens (Human)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000269|PubMed:20531389}. Nucleus {ECO:0000269|PubMed:17545563}.
Interaction partners:
- Exosome complex component RRP45
- Exosome complex component 10
- Exosome complex exonuclease RRP44
- M-phase phosphoprotein 6
- Exosome complex component CSL4
- Nuclear nucleic acid-binding protein C1D
- Exosome complex component RRP4
- DIS3-like exonuclease 1
- Exosome complex component RRP41
- Exosome complex component RRP42
Sequence:
MAEPASVAAESLAGSRARAARTVLGQVVLPGEELLLPEQEDAEGPGGAVERPLSLNARACSRVRVVCGPGLRRCGDRLLVTKCGRLRHKEPGSGSGGGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGGSEPASLSYLSFEGATKRNRPNVQVGDLIYGQFVVANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIIQEVGKLYPLEIVFGMNGRIWVKAKTIQQTLILANILEACEHMTSDQRKQIFSRLAES
Protein: Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) (P34056)
Organism: Mus musculus (Mouse)
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
Subcellular location: Nucleus.
Interaction partners:
- Cbp/p300-interacting transactivator 2
- BTB/POZ domain-containing protein KCTD1
- Transcription factor AP-2-beta
- Cellular tumor antigen p53
- Cbp/p300-interacting transactivator 4
- Protein DEK
- Nucleophosmin
- Histone acetyltransferase p300
- Transcription factor Sp1
Sequence:
MLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALGSGLGDLPIHSLPHAIEDVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVARKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSAKSSDKEEKHRK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9V9X8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MADEKAKESFRERQAQELEVIKSIFGCDVEDLRPQANPSLWKPTDIRIQLTPLRDSSNGLETYVCTKLHVTCPSKYPKLPPKISLEESKGMSDQLLEALRNQLQAQSQELRGEVMIYELAQTVQAFLLEHNKPPKGSFYDQMLQDKQKRDQELQDIQRQRESLQRQTLIDEVERRKEMFKTEAKRRGEPRRSMSESNPRHPSSSESSENSSPYYRGHIYPSKCLDHRNTETLYFHKMGRQIQRGCCVGHSQRGCIAYTGIDMHCGQLLYITEWNIKYSQLEQPCIGGGKCHWSSESKCMGSHRVDEVMASIEKQVSSLSQLQHKNLVSYECVLCIKRKEGLLVYLVQDFLLGTSVFSISSSLGWCMDGARMVARGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFSLVPNLLELLSGAGQSSSCGDLPALGALVESLMPTNSYEMRDFVDKCNSDRTLSASELLEHPFLRFYVDNGQQQVMPLPQQQHPNTVQRTGSAMPYQIPTLALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENVVRYFNSWIESVDDADAAEMDKLLGGEWSQSQQDLSVKPAKSPQLGPTLEEDEDEEDSSSSMWNGYIPNMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTLYVAPELTGNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEMLRHALANPQSKAYKNLVARCLQQESDEVLEHTYHLGSSRAMKSWNSAIIIDDIVSLNPVIEFVKAKVVNLFRKHGAIEVDSPLLSPLSARNSTANANANAVHLMTHSGCVVVLPCDLRTQFARHVTMNSVNLIRRYCVDRVYREERVFNFHPKQSYDCSFDIIAPTTGSHLVDAELLSLAFEITSELPRLREKNLAIRMNHTNLLRAILIFCNVPKAQYGALFEGTMDFIESRISRFQFHSSITGIMEKSRTSAQTLMDMLLANFLLTGSRSTVDDSALKSLMRGKGEAASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGIVWQMTADLKPNRSGHPSVLAIGERYDSMLHEFQKQAQKFNPAMPARGVLSGAGLTFSLDKLVAAVGVEYAKDCRAIDVGICVCGTRPPLKDVTYIMRLLWSVGIRCGIVEAASELGDEAQDLARLGALHVILVAENGSLRVRSFERERFQERHLTRTELVEFIQKMLRSDGLNGTTVDNFSQLSALGSGDNRSSGGKERERGENGLSTSASNATIKNNYSQLPNLQVTFLTHDKPTANYKRRLENQVAQQMSSTLSQFLKKETFVVLVVELPPAVVNAIVGAINPREIRKRETEPEINYVIERFSKYKRYISEINEEVVDYLSDAKTPIVALYSISDSYYRVII
Protein: Large ribosomal subunit protein bL32c (50S ribosomal protein L32, chloroplastic) (P61847)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein bS16cz
- Large ribosomal subunit protein bL33c
- Large ribosomal subunit protein bL20c
- Small ribosomal subunit protein uS8c
- Small ribosomal subunit protein uS12cz/uS12cy
- Large ribosomal subunit protein uL22c
- Large ribosomal subunit protein uL14c
- Large ribosomal subunit protein bL36c
- Small ribosomal subunit protein uS7cz/uS7cy
- Large ribosomal subunit protein uL2cz/uL2cy
Sequence:
MAVPKKRTSISKKRIRKKIWKRKGYWTSLKAFSLGKSLSTGNSKSFFVQQNK
Protein: Polyprenal reductase 1 (EC 1.3.1.94) (Q9CAH5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Involved in the regulation of plant growth and reproductive processes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26628744}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dolichol kinase EVAN
- Alpha/beta-Hydrolases superfamily protein
- Small ribosomal subunit protein eS17w
- At3g49420
- NAD
- Alpha/beta-Hydrolases superfamily protein
- Polyprenal reductase 2
- Ribosomal protein S24/S35
- Expressed protein
- At4g13500
Sequence:
MEVEIVWLVKAAWITVWIVSILPLVIASIPSSKLNSFRELVLSFAGRGKILHPSSQKFTVPQKFFGHFYVVGVVWTTLLLAATWMYACKMAGGSHVFSFHMTHVEHRFKVGRAVFLLLLMEIHVLRRVIESFYVFKYSTSARMHILAYVGALFYYVAAPLSLCSNIAPEVARFVGSQVAEFIASGKSHSHDFNLLLSISPLMKLGSLQWIGGAIFLWGWIHQRRCHAILGSLREYPSQAKEYIIPYGDWFEMVSCPHFLAEIVLYLGLLISSGGTDISIWLLFGFVAANLTYAAGETHRWYLQKFENYPASRHAIFPHVY
Protein: diguanylate cyclase (EC 2.7.7.65) (A0A0H2X359)
Organism: Xanthomonas campestris pv. campestris (strain 8004)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MTCHTSNGAVEPTGSVAKTLSDGLHALMTAEELAFFARFGRMREIAAGQALFERGAVGTQMFIVVTGQIDLDFGEDLMLKHLGPGEFFGELGLLIGDHARSAGASASVDSRLIELAHDDFQRLVDHDPSMVAHFLRRSIVRVVNNEQLLIRQLRRRNHDLEAALDNLYVTSHQLNHTEELSRTDELTGLHNRRGLALHLQECRRGGGAPGVGLILIDCDRFKHINDEYGHLAGDRVLQNVAHALRSVIAEGDLVCRLGGDEFCVLVAQGSIELVQHMGECIVNAVQARQASSPDGCHSCSVSVGVCSIDASTSYNDWYTRADTALYQAKRQGGNSLCVYEALPLDNS
Protein: Nascent polypeptide-associated complex subunit alpha-like protein 5 (NAC-alpha-like protein 5) (Alpha-NAC-like protein 5) (Q8LGC6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May promote appropriate targeting of ribosome-nascent polypeptide complexes.
Interaction partners:
- Nascent polypeptide-associated complex subunit beta
- Basic transcription factor 3
- Large ribosomal subunit protein uL18y
- Probable elongation factor 1-gamma 2
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein uL22z
- Nascent polypeptide-associated complex subunit alpha-like protein 1
Sequence:
MPGAIVEEEKSQIESIKEQLKLEKEDDVVVEDVKDGEEEDDDEDDEDVEVEGEGGNENAKQSRSEKKSRKAVLKLGMKPVSDVSRVTIKRAKNVLFVISKPDVYKSPNAETYVIFGEAKVDDLSSQLQTQAAQRFKMPDVTSMLPNAGSEATMAPLAEEEDEDDVDDTGVEARDIDLVMTQAGVSKAKAVSALKANDGDIVSAIMELTT
Protein: BCL6A transcription repressor a (F1R5N6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- BCL6A transcription repressor b
- Nuclear receptor corepressor 2
- BCL-6 corepressor isoform X1
- Nuclear receptor corepressor 1.
- Chemokine
Sequence:
MQEVSRKALPDLEKMACAADSCIQFTRHASDVLLNLNRLRSRDILTDVTILVNRQQFRAHKTVLMACSGLFYSIFTDSHKCNLNAISLDPKVDPEGFAILLEFMYTSRLALKESLIMAIMNTAIYLQMDHVVDTCHRFIKSSDSSIKLPREDFLVSPLLLPQDIHSYRPHEVMDNVSGRSATFRDGRPYGVCMFNGVNAPNNSYLYGQFPMQGFPFPLCKLTDTKNTFSDFSKGGIIHHKHCSPSDGNNPVLNDFTRSATSGSSAVCHTGSYSSRELGRDEDMKRETLEGVVHSIGMSSRKHGFISLAQEQQRESGKEQSSLAEEHLSHQHYSMGISSNGRKTLMSSPQSPLKSDCQPNSPTESSSSKNAALAQALQPPTSQGTSDPKARNWKKYKFIVLNQSSKEEETNPPDPGMHSPQRPGLSAFLHHVDSEHPDSKVTTKISEQGEDFPAPQASRLNNIINRSLEGSQRNIDSHSSLYMNHLKCSSCGSQSPQHSDVCPNTSASRLAEEMSEMHSEYSDSSCENGTYFCNECDSKFAEEEALKRHTLQVHSDKPYKCDRCQAAFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKIQYRMSSTELPTDLTKAC
Protein: Tripartite motif family-like 2 (A0A1B0GSQ3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSQAPKPQLPGNTEDPNCGTHPEPSQFFSDDDQVIVCSKCFQSPEHKQHGAYGIQEAAEYYRTLLQETLVTLREKRDAATSLLAEERERMVTIQEEEQRFKEMIEAEYKMRFQLLTEEEELAAYKVDLNLNGPNPDQLMKCGTELMQKSQEMLQNAKCYLKRNESILLQSLEPAQITDLSFCLIIETSRVLLRLQRHITLDPGTAHPSLVLSEDLRSVGFRETPKTGPGTTRRLDFSASVLGAESFTTGRHYWEVAVGQATQWQVGICDCTERKDNIPGASGDKVLLMGSMMGTDCTLWVFPPLRKVCLRNQMYKVGVFLDCECGQVSFYNVTEQSLIYSFSDLTFRGAIKPIFSLCIPNGDMSSDSLTVCLPQTHP
Protein: Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3) (O15524)
Organism: Homo sapiens (Human)
Function: Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Interaction partners:
- Non-receptor tyrosine-protein kinase TYK2
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK2
- Elongin-B
- Elongin-C
- Interferon alpha/beta receptor 1
- Cullin-2
- Insulin receptor substrate 2
- Insulin receptor substrate 1
- Cullin-5
Sequence:
MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI
Protein: E3 ubiquitin-protein ligase wwp-1 (EC 2.3.2.26) (Q9N2Z7)
Organism: Caenorhabditis elegans
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates klf-1. Required for diet restriction-mediated lifespan extension, acting in concert with Kruppel-like factor klf-1 in the intestine to perhaps modulate genes involved in lipid metabolism. Probably acting downstream of the Insulin/IGF-1-like signaling (IIS) mediated pathway, plays a role in the immune response to infection by the Gram-negative bacterium P.aeruginosa, at least partly in response to bacterial pore-forming toxins.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 ubc-18
- E3 ubiquitin-protein ligase
- Receptor tyrosine-protein kinase let-23
- Inheritance of peroxisomes protein 1
- Ubiquitin-ribosomal protein eL40 fusion protein
- Polyubiquitin-A
- Kruppel-like factor 1
- DNA-directed RNA polymerase II subunit RPB1
- Ubiquitin-like domain-containing protein
- Hepatocyte growth factor-regulated tyrosine kinase substrate
Sequence:
MARNEPSSQQPSSSGSNGTPAQQNGSAKPSKVTVKVVNASFTKAADCYVEITSDTSSAAPKKTTVKKKTMAPEWNEHLNVHANESSTISFRLLQKAKLFDDTCLGMAKLKLSSLTRNENGEFKNDINNISLLAKDSSKIGTLNIIFSGYPERKRRSAGVRAETAASASSEASTSNGVATSSSARRPATAKRDTLAAPTSTAAAAAAATAGGTPAAGAEEQLPDGWEMRFDQYGRKYYVDHTTKSTTWERPSTQPLPQGWEMRRDPRGRVYYVDHNTRTTTWQRPTADMLEAHEQWQSGRDQAMLQWEQRFLLQQNNFSADDPLGPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGFRGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFRYLCLSNSVPNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFGNE
Protein: Chaperone protein DNAJ, putative (Q586W6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNRSSSTSVNKDNVLQLTYYEIFSLDEVAESIDLQALHRAYRRFALLFHPDKDASPEAREAFLRVKLAAETLSDPIKRQEYNEQLRREAHEQREVKEQQRECGVGEEAIMAEMILRQKEAESLAKSAAANKEAAEREAAAKKMINELTNALTTPFKQMETALVSEWDIDEGLLDMKVNEIRLLLQKLHNLSCHREGRKGGGGAMGFSSGSEALPTAVKRTREESGVNITA
Protein: Zinc finger protein ZAT6 (COLD INDUCED ZINC FINGER PROTEIN 2) (O22533)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that regulates root development and phosphate (Pi) acquisition and homeostasis. Probably acts as a repressor of primary root growth and regulates Pi homeostasis through the control of root architecture.
Subcellular location: Nucleus {ECO:0000269|PubMed:17631527}.
Interaction partners:
- Heat stress transcription factor A-4a
- Probable WRKY transcription factor 75
- Protein PHOSPHATE STARVATION RESPONSE 1
- Transcription factor MYB62
- Transcription factor AIG1
- Inorganic phosphate transporter 1-1
- Probable ubiquitin-conjugating enzyme E2 24
- Zinc finger CCCH domain-containing protein 29
- Ethylene-responsive transcription factor 5
- Glutamate--cysteine ligase, chloroplastic
Sequence:
MALETLTSPRLSSPMPTLFQDSALGFHGSKGKRSKRSRSEFDRQSLTEDEYIALCLMLLARDGDRNRDLDLPSSSSSPPLLPPLPTPIYKCSVCDKAFSSYQALGGHKASHRKSFSLTQSAGGDELSTSSAITTSGISGGGGGSVKSHVCSICHKSFATGQALGGHKRCHYEGKNGGGVSSSVSNSEDVGSTSHVSSGHRGFDLNIPPIPEFSMVNGDEEVMSPMPAKKLRFDFPEKP
Protein: GYF domain-containing protein mpd2 (O36025)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in mRNA export from the nucleus.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative ATP-dependent RNA helicase ste13
- Uncharacterized protein C167.05
- Probable metal homeostasis protein bsd1
- Polynucleotide 5'-hydroxyl-kinase grc3
Sequence:
MNSEASVFSNMDWSQLAHSLHKKANNSSSSTTGAFPQLTSFTKPTATNGVDSPTSSHIDPSVSAKLDSQRKLSLKSGNMWDSLNAPSELTSKNPTVSSTTSSANPAIVSNGGSPFYKNPVVANNPSSTFDMSTNLFNSKNANTSFTNAFSNEGISPGFLRDCFPSSNSITTGTASPKLGSPFNHINRPVLDRSPSSFSQSRSAVSGNMNPGVGTLQQPQRAGSDTFPDLNTSSSNQPGGEPNVASANTHSLEILSSSAYHPSGSSNGISAGLTQSVASPVGQVDNLADFSQSPLRRGPSRFPTNSNVPVGNSMSIRDTDSPLNILVDKAKAKASIKENASQPVAPSASQREHSAVNSPAAAMSPSTAMFSSEAFPQHLASLIPPALLHWLYKDPQNNVQGPFTGVDMHQWYRAGYFPLGLPIKRLEEEEYYSLAFFIRQVGNQLEPFLVPLSPVTVQNASWNAQGTDLPLSNYLPESSEQNRGGNKHLELYPSTAEVSNVRNDESKANSLSEISYNQQSECRSSELNVNEDSANQKEESALGTSDNSDMYEKENTPIHHNESLNQLSKDLGSISLSEETKQEKPSKLKETVESKRLSTGVQKQSPAASKEIPVTSGSQTTAPKPSPWKSLPPKHLPSLDETISREMSIASSEALPQVEKSNSDQPPVAIPSTSKTGSPWAKVSDVSTSMAQEIQRMEKQNENLKSKVASNPVSQTSTNAKASTPALASGSIWGSPSVINAWANKPAALKSPLIKKNIQQAELAQNKQQSSVTTASPRSNALNANTPKAAAPSSNVTMKNVTSILETSTFEGEDTWSVVGPGGKIVNQQSPSAQQTTRSPSKVSATLNAGNSQASTSSKLQQVVSMSGHSPDFLAWCKISLKGLNEGVNYEEFLDMLLSLPAENNVETFEIISDSIYANSTIMDGRRFASEFTRRRIADLTGKDGQQSNNKSQSELGNSSGAWSQVVRNKPKQGTEWNSAFKVVTSKKNKKRV
Protein: Retrotransposon-derived protein PEG10 (MmPEG10) (Embryonal carcinoma differentiation regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3) (MyEF-3) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein) (Q7TN75)
Organism: Mus musculus (Mouse)
Function: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids. Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA. Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region. Involved in placenta formation: required for trophoblast stem cells differentiation. Involved at the immediate early stage of adipocyte differentiation. Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (By similarity). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result.
Subcellular location: Extracellular vesicle membrane {ECO:0000269|PubMed:30951545, ECO:0000269|PubMed:34413232}. Cytoplasm {ECO:0000269|PubMed:30951545}. Nucleus {ECO:0000250|UniProtKB:Q86TG7}. Note=Forms virion-like extracellular vesicles that are released from cells. {ECO:0000269|PubMed:30951545, ECO:0000269|PubMed:34413232}.
Interaction partners:
- Epsilon-sarcoglycan
- Mesoderm-specific transcript protein
- Pleiomorphic adenoma gene-like 1
- Neuronatin
- Small nuclear ribonucleoprotein-associated protein N
- Nucleosome assembly protein 1-like 5
- Protein delta homolog 1
Sequence:
MAAAGGSSNCPPPPPPPPPNNNNNNNTPKSPGVPDAEDDDERRHDELPEDINNFDEDMNRQFENMNLLDQVELLAQSYSLLDHLDDFDDDDEDDDFDPEPDQDELPEYSDDDDLELQGAAAAPIPNFFSDDDCLEDLPEKFDGNPDMLGPFMYQCQLFMEKSTRDFSVDRIRVCFVTSMLIGRAARWATAKLQRCTYLMHNYTAFMMELKHVFEDPQRREAAKRKIRRLRQGPGPVVDYSNAFQMIAQDLDWTEPALMDQFQEGLNPDIRAELSRQEAPKTLAALITACIHIERRLARDAAAKPDPSPRALVMPPNSQTDPTEPVGGARMRLSKEEKERRRKMNLCLYCGNGGHFADTCPAKASKNSPPGKLPGPAVGGPSATGPERIRSPPSEASTQHLQVMLQIHMPGRPTLFVRAMIDSGASGNFIDQDFVIQNAIPLRIKDWPVMVEAIDGHPIASGPIILETHHLIVDLGDHREILSFDVTQSPFFPIVLGIRWLSTHDPHITWSTRSIVFNSDYCRLRCRMFAQIPSNLLFTVPQPNLHPYLLHHVHPHVHPHMHQHLHQHLHQFLHPDPHQYPHPDPHYHHHQQADMQHQLQQYLYQYLYYHLYPVMHHHLPPDQHEHLHEYLHQYLHQYLHQFLHHHLHPDLHQYLYQYLHNHMNPDPHHHPHPDPPQDPHHPPHQDPHQHPDPHQDPPHQDPHQDAHQDPHMDPHLHQHQHPQPQPHPQQHPNHPQQPPFFYHMAGFRIYHPVRYYYIQNVYTPVDEHVYPGHRVVDPNIEMIPGAHSLPSGHLYSMSESEMNALRNFVDRNVKDGLMTPTVAPNGAQVLQVKRGWKLQVTYNCRAPQSGTIQNQYLRMSLPNMGDPAHLASYGEFVQVPGYPYPAYVYYTSPHMMTAWYPVGRDVHGRIIVVPVVITWSQNTNRQPPVPQYPPPQPPPPPPPPPPPPPPPPASSCSAA
Protein: Surface-associated protein (Q9AIP9)
Organism: Methylococcus capsulatus
Interaction partners:
Sequence:
MRDTMNEKHCYSLLAAGLIAAVPQLAAAHGGTHDVTAVAHLSYSEAYSEKLKKGQEVGTELLVLDGRFEFNEHVGMGDITPDTTWSAVVQGQTLATGTLGDATKKKFGAKGGMAVINVPGGGTLKFTWNAKAIMLKLKWTGEPALARLYKDQNTSINLPQFPVDIAIGSLHGYFNVPVTGQAKATTKNGTMLSKIALKGTANSAGLDTLDRDGDGSTADADCNDFAPTIHPGAAEATLDGVDSNCDGRDSGVAEVVETFKNPGTYSSPVINFKIASPPGPGTPIYGPPRDFSGYNKSYSLAIGKTSYYDPTTGTKWNDDTITPVSDGQDIWRGWTHTGKWSFFNGKAGDKITLSVQRDAQEASLKGAHPGFILFWRPEGGPLFWAGTQDLDEGQTALPADSDTVIGHVIVQHADWTLQGLPPKADHTAPAGVDTELYPMKPDSYTMYYVDSGYDADKYVASKKLIMHPTAFKGLALNDGTAGAFTKSITLPKTGYYMLYVANVLEVDDWSVDADGKLTTTGEVWEVPAKGCWVNITISKP