wanglab/gogpt-training-data huggingface dataset:
Protein: Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) (P07313)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Implicated in the level of global muscle contraction and cardiac function (By similarity). Phosphorylates a specific serine in the N-terminus of a myosin light chain.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11733062}. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
Interaction partners:
Sequence:
MATENGAVELGIQSLSTDEASKGAASEESLAAEKDPAPPDPEKGPGPSDTKQDPDPSTPKKDANTPAPEKGDVVPAQPSAGGSQGPAGEGGQVEAPAEGSAGKPAALPQQTATAEASEKKPEAEKGPSGHQDPGEPTVGKKVAEGQAAARRGSPAFLHSPSCPAIIASTEKLPAQKPLSEASELIFEGVPATPGPTEPGPAKAEGGVDLLAESQKEAGEKAPGQADQAKVQGDTSRGIEFQAVPSERPRPEVGQALCLPAREEDCFQILDDCPPPPAPFPHRIVELRTGNVSSEFSMNSKEALGGGKFGAVCTCTEKSTGLKLAAKVIKKQTPKDKEMVMLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKEQGARMSAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
Protein: Sterol esterase 1 (EC 3.1.1.13) (Steryl ester hydrolase 1) (Q07804)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mediates the hydrolysis of steryl esters, thereby playing a central role in lipid metabolism. Under heme-deficient conditions, it constitutes the major steryl ester hydrolase, suggesting that it plays a central role in mobilization of steryl esters under anaerobic conditions.
Subcellular location: Lipid droplet. Membrane; Peripheral membrane protein.
Interaction partners:
- Triacylglycerol lipase 5
- Very long-chain fatty acid transport protein
- Triacylglycerol lipase 3
- Triacylglycerol lipase 4
- Sterol O-acyltransferase 2
- Diacylglycerol O-acyltransferase 1
- Lanosterol synthase ERG7
- Phospholipid:diacylglycerol acyltransferase
Sequence:
MGVSAVLKRARNLLATFIVCCFMAVVLVLALAHHFINEHRDTRSSSTQIEVDDESKRNVHHDHVLTRTNAYATPYLDLEHDKKNGIVYDHTRTVVRKKNHEVGSSSLHKNLFHKFLTKLIFRFIEKEKVTEGVTQGKFNNSSNEIANHEPVFEKIPVQCDNPLQNLILSEDLTLVADLNYYFNQYNIQIEEFRLETEDGFVIDLWHLIPKYRTTDSDKKKRPPILMLHGLLQSSGSFASNGRKSLAYFLYQSGYDIWLGNNRCGFRPEWNEAKVPTLASRWDWDLREMVKYDLTLLIDTVLAKTQFEKLTLISHSQGTTQGFMGLVNEDKFFPPGSGSKESFFTSKIANYIALAPAVYPGPLLNEKLFVKLMTKEIENPWFFGETSFFEIMMIVRNLCVGESLFSFVCYTIFNYLFDWNDTLWDTALRDRHFLFSPVHVSVKLMQWWLSPDPNKVSFKFGSHKMFPDNVKWFSDASKAPNIYLFVPKQDRLVDGERLINHFVNVESNVNYKIWYIDEYAHIDVLWAHDVIERIGKPILQNLNNYYSKKPSSAFESDCSDTEVETELEMVAEKA
Protein: Stress response protein bis1 (Splicing factor ESS-2 homolog) (O59793)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in maintaining cell viability during stationary phase induced by stress response. May be involved in pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:11751918}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11751918}. Note=During mitosis associates with the spindle microtubules.
Interaction partners:
- Pre-mRNA-splicing factor cwf3
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-processing factor 19
- G-patch domain-containing protein C1486.03
- Pre-mRNA-splicing factor cwf4
- Pre-mRNA-splicing factor brr2
- Pre-mRNA-splicing factor cwf2
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor cwf14
Sequence:
MSLAKKIDDDEKQLVKPVNKEQTYKKPIPLEEDDYIEGLSYIIQQQYFPDLPKLKAEVVLESEEVGSFDAQNESRDEKLKYLIAKNSEDPLRKRLPSLAIHEITKAQLDGENKPISVASYQNKFTSEDNASFGELMEDESRLRAEQHKRRFGVHSQQPSNSIQTIGYSNSDAIKSIAWKEKDKSIKTWNYQPKNALMYTPETNHSSSLSQIKKQSTEIQADATGLSQSFLEAANQPSTDPIVPPSVNETDASVNGYPLVDVNFGQAVGSSSKSYFNIPERPRRERLHAMRVRDIRSHSTNTTITSVDSASTALNSYSTPNSVSRKLTNLTPAARRLVARSYLRSPLHGSSPSASRHTALRTSIPKFSWTPTPRVKSTAPTPKRV
Protein: Protein bud22 (O36018)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- rRNA biogenesis protein rrp36
- Uncharacterized NOC2 family protein C1142.04
- Ribosomal RNA-processing protein 7
- Pescadillo homolog
- Protein cms1
- RNA cytidine acetyltransferase
- Uncharacterized protein C4F10.09c
- Ribosome biogenesis protein slx9
- Multiple RNA-binding domain-containing protein 1
- Ribosome biogenesis protein enp2 homolog
Sequence:
MVFTSHKGVKRKSHHSQLSVDDVPKKIPLFKKKISQALKKASTFERQKLVRRIKNCRASEDADTLGRFEAEFEFAKQFDFTKFVDYCYYKKILKNKDFRKLLNENLHVDFPADLTEDAQRNTVARILNSKQLSDAIRNINSILEKYLRFLNPDLQELSDKKAVSSTQKPIKTIGKVDLSNKSTSNQDQVDNTHVQNSTDGVNQDTGMILDNTEDKEINKSMSYSMKNEGVKESSLQNATLINRKSIIDDEMLEIPLGKHNNTNLPALTAGFLDPVESDDEFVEKELEEVDIPKRKNRRGQRARQAIWEKKYGKGANHLIKKATEERSIREERQRKYEERQAKRAARENAFTEHQTPQKPEQLHPSWEAKRKQKMPSSAAFQGKKIVFD
Protein: Uncharacterized protein Rv1510 (P9WLW1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Glucose-1-phosphate thymidylyltransferase
- dTDP-4-dehydrorhamnose 3,5-epimerase
- UDP-glucose 6-dehydrogenase
- UDP-galactopyranose mutase
- Probable sugar transferase
- Putative fatty-acid--CoA ligase fadD25
- Probable transposase
- Uncharacterized protein Rv1509
- Putative glyoxylase CFP32
- dTDP-glucose 4,6-dehydratase
Sequence:
MYERRHERGMCDRAVEMTDVGATAAPTGPIARGSVARVGAATALAVACVYTVIYLAARDLPPACFSIFAVFWGALGIATGATHGLLQETTREVRWVRSTQIVAGHRTHPLRVAGMIGTVAAVVIAGSSPLWSRQLFVEGRWLSVGLLSVGVAGFCAQATLLGALAGVDRWTQYGSLMVTDAVIRLAVAAAAVVIGWGLAGYLWAATAGAVAWLLMLMASPTARSAASLLTPGGIATFVRGAAHSITAAGASAILVMGFPVLLKVTSDQLGAKGGAVILAVTLTRAPLLVPLSAMQGNLIAHFVDRRTQRLRALIAPALVVGGIGAVGMLAAGLTGPWLLRVGFGPDYQTGGALLAWLTAAAVAIAMLTLTGAAAVAAALHRAYLLGWVSATVASTLLLLLPMPLETRTVIALLFGPTVGIAIHVAALARRPD
Protein: Rab GTPase-binding effector protein 2 (Rabaptin-5beta) (Q9H5N1)
Organism: Homo sapiens (Human)
Function: Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29247183, ECO:0000269|PubMed:9524116}. Early endosome {ECO:0000269|PubMed:9524116}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27224062}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27224062}.
Interaction partners:
- Rab5 GDP/GTP exchange factor
- Ras-related protein Rab-5A
- Serologically defined colon cancer antigen 8
Sequence:
MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT
Protein: Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) (Q8BJU2)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305|PubMed:18795891}; Multi-pass membrane protein {ECO:0000305|PubMed:18795891}. Note=Colocalizes with GP6 in tetraspanin microdomains on the platelet surface.
Interaction partners:
- Tetraspanin-32
Sequence:
MARGCLCCLKYTMFLFNLIFWLCGCGLLGVGIWLSVSQGNFATFSPSFPSLSAANLVIAIGTIVMVTGFLGCLGAIKENKCLLLSFFIVLLIILLAELILIILFFVYMDKVNENAKQDLKEGLLLYNTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENSQGCGRNSTTPLWRTGCYEKVKLWFDDNKHVLGTVGMCILIMQILGMAFSMTLFQHIHRTGKKYDA
Protein: Receptor like protein 28 (AtRLP28) (O49325)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Receptor-like kinase
Sequence:
MSGSHLRLRFLSLLLLCCVSSSTSSLFTFSYPVLDLVACRSHQIQAFTQFKNEFDTHRCNHSDHSNGVWCDNSTGVVTKLQLNACLSGTLNPNSSLFWFHQLRFLNLSHNNFTSTSFPSEFGNLNKVEVLDLSFNSFTGQVPSSFSNLSQLTELHLSNNQLTGGFPQVQNLTNLSHLDFENNKFSGTVPSSLLMMPFLSYLNLYGNHFTGSIEVSTSSKLEILYLGLKPFEGQILEPISKLINLKRLELSFLNISYPLDLNLFSSLKSLTYLDLSGNSISPRSLRSDLYIPLTLEKLLLEQCGIIEFPNILKTLQKLEYIDMSNNRINGKIPEWLWRLPRLRSMSLANNSFNGFEGSTDVLVNSSMEILFMHSNNIQGALPNLPLSIKAFSAGYNNFSGEIPLSICNRSSLAALSLPYNNFTGKIPQCLSNLTFVHLRKNNLEGSIPDTLCAGDSLQTLDIGFNLISGTLPRSLLNCSSLEFLSVDNNRIKDTFPFWLKALPNLQVLILSSNKLYGPIAPPHQSPLAFPELRIFEIADNMFTGTLSPRYFVNWKTSSLTVNEDGDLYMVYKNNAFGIDSYVYRDTIDMKYKGLSMEQQMVLNSYSAIDFSGNRLEGQIPKSIGLLKELIALNLSNNAFTCHIPLSLANATELESLDLSRNQLSGTIPNGLKTLSFLAYINVSHNKLKGTQIIGQHKSSFEGNAGLCGLPLEETCSGKNAPPTQQPKEEDEEQEQVLNWKAVATGYGTGLLLGLAIAQVIASYKPDWLVKIIGLFRFCF
Protein: 4-nitrophenylphosphatase (EC 3.1.3.41) (Q8IBV0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Inosine-5'-monophosphate dehydrogenase
Sequence:
MALIYSSDKKDDDIINVEKKYESFLKEWNLNKMINSKDLCLEFDVFFFDCDGVLWHGNELIEGSIEVINYLLREGKKVYFITNNSTKSRASFLEKFHKLGFTNVKREHIICTAYAVTKYLYDKEEYRLRKKKIYVIGEKGICDELDASNLDWLGGSNDNDKKIILKDDLEIIVDKNIGAVVVGIDFNINYYKIQYAQLCINELNAEFIATNKDATGNFTSKQKWAGTGAIVSSIEAVSLKKPIVVGKPNVYMIENVLKDLNIHHSKVVMIGDRLETDIHFAKNCNIKSILVSTGVTNANIYLNHNSLNIHPDYFMKSISELL
Protein: Type-1 angiotensin II receptor (Angiotensin II type-1 receptor) (AT1 receptor) (P25104)
Organism: Bos taurus (Bovine)
Function: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P30556}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30556}.
Interaction partners:
- Angiotensinogen
- Type-2 angiotensin II receptor
- Plasminogen activator inhibitor 1
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha
- G protein subunit alpha 12
- G protein subunit alpha 13
- Prothrombin
- Angiotensin-converting enzyme
- Angiotensin-converting enzyme
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
Protein: Lupus La protein (Q54TG6)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSEETSTQILKQVEYYFSDSNFPRDKFLRSEAAKNVDNYISIDVIASFNRMKTISTDLQLITEALKKSTRLQVSEDGKMVRRLDPLPENIDCGKTLYSKGWPEDTTIEKVQEFFNANGGYKVVSVRLRKKSDKSFKGSFLADFETEEIVNKIITEAPKLGEKELIYQTFKQFSDEKKDEKEKFFASTNGDKKRKAKKEADRENGDDDDNDGDNKDVKKEVEEEEVMIPGVILCFKGVGKGLHRGDIKEIFSQYGEVQFVGYNSDEENGSVRYKTAESCKRAIESLTETKKEIGGQIPTYNLLEGEEEKKEWEKIIERKKNAAKNGGFKKGGFKKGGFKKGGFKKGGNFKKVKKE
Protein: At1g54500/F20D21_31 (Rubredoxin, putative) (Rubredoxin-like superfamily protein) (Q9SLI4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Thioredoxin family protein
- Light-harvesting complex-like protein 3 isotype 1, chloroplastic
- Protein HHL1, chloroplastic
- Heat shock 70 kDa protein 18
- Protein ACTIVITY OF BC1 COMPLEX KINASE 3, chloroplastic
- 2-Cys peroxiredoxin BAS1-like, chloroplastic
Sequence:
MASATFSFCPLSQSHPHSSLIKPTPFLRYGKKLHHLHHHIFITISYPSHHSRYLAVSRDDAATPLSSSDQTQETETKEVEDTIEKRRMEEKFAVLNTGIYECRSCGYKYDESAGDPSYPIPPGFQFDKLPEDWRCPTCGAAQSFFESKMVEIAGFAQNQQYGLGGNALTSGQKTGLIFGSLLLFFALFLSGYFIQ
Protein: Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) (Q00526)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
Interaction partners:
- Cyclin-C
- G1/S-specific cyclin-E2
- Cyclin-dependent kinases regulatory subunit 2
- Cyclin-A2
- Cyclin-dependent kinases regulatory subunit 1
- CDK5 and ABL1 enzyme substrate 1
- Cyclin-dependent kinase inhibitor 1
- Cyclin-dependent kinase 2
- G1/S-specific cyclin-E1
- G2/mitotic-specific cyclin-B1
Sequence:
MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH
Protein: Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis protein 7) (Endosomal recycling protein 1) (Regulator of rDNA transcription protein 2) (P38332)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate in diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EFT1 and EFT2). Also plays a role in the regulation of the retromer complex and is required for the recycling from endosomes of plasma membrane proteins like CAN1 and MUP1. Identified in a screen for mutants with decreased levels of rDNA transcription.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21880895}. Endosome {ECO:0000269|PubMed:21880895}. Note=Recruited to endosomes in cells in which increased recycling of internalized plasma membrane proteins occurs.
Interaction partners:
- Elongation factor 2
- Diphthine--ammonia ligase
- Diphthine methyl ester synthase
- 2-
- 2-
- Diphthamide biosynthesis protein 3
- Diphthamide biosynthesis protein 4
- tRNA
- Protein KTI13
Sequence:
MDSIQESDVLNAVKTKLPPCCLRIFRNKIILVGTYDLDKSTGYRSGSLDVFTMDLKLLCSNNTYGAILDLKLSPFDDTLICTAHSTGNIMLWRIRCTDKDDFQSNELDIHAIANLQLFEKDVLIASCHFSPLDCKKLLVTNTAGEAATIDIRTLSVQFTASAIAQAYSKLDKIDYEVQGATEKVIHVESGQFLKPHELECWTAEFGSLQPFQDVVFTGGDDSRIMAHDLRSKEFIWSNNRIHDAGVVSIKCSQPNFRNNKPTSIITGSYDDNIRSLDLRMMGESIFPGANVPTVNKLACDLGGGVWRFVESPIDQEQSHHNGSDRLLVCCMYNGAKVVTMNDNSDEYFQIQHYLKKGHDSMCYGGDWSNSLIATCSFYDNSLQTWIV
Protein: Rifin (Q8I3E7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHCYNILLFSLLLHRLLLSSSKVNIEMNHHNTPHIKNREPTKSYRSLCECELYTYIYDDDPDMKEIMNDFDRQTSQRFEEYNERVNKNRQKCKEQCDRDIQNIILKDKVEKSLSEKVEKGCLRCGCGLGGVAAGVGIFGALGTYGWKVAATATAIEFATQEGIKAGIQAAIEQIKITVFNSLLNVEWLNFINASNYNSIAGLVEAVKAAVVSTERTSELSSNTMDRVRNALSEAENWFSPAVREGTQTTASTITTVQRTQLVDVTATSTYSYMAIAYSVIAILIIVLVMIIIYLILRYRRKKKMNKKAQYTKLLNQ
Protein: PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (Q4V7A6)
Organism: Rattus norvegicus (Rat)
Function: Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Bromodomain containing 7
- Protein polybromo-1
- Actin-like protein 6A
- AT-rich interactive domain-containing protein 2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- Actin-like protein 6B
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Sequence:
MAAAGPGAALSPRRCDSDPASPGAQSPKDDNEDNSNDGGHPSKRRRMGSGDSSRSCETSSQDLSFSYYPAENLIEYKWPPDETGEYYMLQEQVSEYLGVTSFKRKYPDLERRDLSHKEKLYLRELNVITETQCTLGLTALRSDEVIDLMIKEYPAKHAEYSVILQEKERQRITDHYKEYSQMQQQSTQKVEASKVPEYIKKAAKKAAEFNSNLNRERMEERRAYFDLQTHVIQVPQGKYKVLPTDRTKVSSYPVALIPGQFQEYYKRYSPDELRYLPLNTALYEPPLDPELPALDSDGDSDDGEDGGGDEKRKNKGTSDSSSGNVSEGDSPPDSQEDTFQGRQKSKDKMATPRKDGSKRSVLSKSVPGYKPKVIPNALCGICLKGKESNKKGKAESLIHCSQCDNSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICGQPHHEEEMMFCDVCDRGYHTFCVGLGAIPSGRWICDCCQRAPPTPRKVGRRGKNSKEG
Protein: Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase) (P17178)
Organism: Rattus norvegicus (Rat)
Function: Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid. Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways. May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism. Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation. Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium. May play a redundant role in vitamin D biosynthesis (By similarity). Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:19401463}; Peripheral membrane protein {ECO:0000305|PubMed:19401463}. Note=Post-translationally targeted to mitochondria. All three of the receptor proteins in the TOM complex, TOMM70, TOMM20 and TOMM22 are required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. {ECO:0000305|PubMed:19401463}.
Interaction partners:
- 25-hydroxycholesterol 7-alpha-hydroxylase
- Cytochrome P450 7A1
- Cholesterol 25-hydroxylase
- Long-chain fatty acid transport protein 5
- Cytochrome P450 family 8 subfamily B member 1
- Cholesterol 24-hydroxylase
- 7-dehydrocholesterol reductase
- Delta
- Lysosomal acid lipase/cholesteryl ester hydrolase
- Sterol O-acyltransferase 1
Sequence:
MAVLSRMRLRWALLDTRVMGHGLCPQGARAKAAIPAALRDHESTEGPGTGQDRPRLRSLAELPGPGTLRFLFQLFLRGYVLHLHELQALNKAKYGPMWTTTFGTRTNVNLASAPLLEQVMRQEGKYPIRDSMEQWKEHRDHKGLSYGIFITQGQQWYHLRHSLNQRMLKPAEAALYTDALNEVISDFIARLDQVRTESASGDQVPDVAHLLYHLALEAICYILFEKRVGCLEPSIPEDTATFIRSVGLMFKNSVYVTFLPKWSRPLLPFWKRYMNNWDNIFSFGEKMIHQKVQEIEAQLQAAGPDGVQVSGYLHFLLTKELLSPQETVGTFPELILAGVDTTSNTLTWALYHLSKNPEIQEALHKEVTGVVPFGKVPQNKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPESFQPHRWLRKREDDNSGIQHPFGSVPFGYGVRSCLGRRIAELEMQLLLSRLIQKYEVVLSPGMGEVKSVSRIVLVPSKKVSLRFLQRQ
Protein: Male abnormal protein mab-31 (Q9N3E2)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000269|PubMed:20687916}.
Interaction partners:
- DNA mismatch repair protein S5 domain-containing protein
- DNA mismatch repair proteins mutS family domain-containing protein
- DNA mismatch repair protein
- MutS protein homolog him-14
- MutS protein homolog 5
- Serine/threonine-protein kinase receptor sma-6
- Exonuclease 1
- A disintegrin and metalloproteinase with thrombospondin motifs adt-2
Sequence:
MNSLEYLIANPHILSDTTLTDALAALASSTNVENQDEEFDMEVNSDDEMKIDLSALINPSVFNALQLPIGTGRFPNPSPPRSSSGTNTPIRKTPGSRPDRGKFTILDNAEVAGPEEVLNVNFDSEILQRIFSDPKLGIQFLARYGLIPNTRVCRVQDCPKDQLMSLIKHANGFVWRCRSCRKRREKRIITKISVYEGTFLFYSRMPLNKFFIFMLNWCENPGLSITEYNRLMGENRLVEETIYNTIGFMRDIIQNWCDTIISSHVPIGGPHRVVEVVETLSTEQLSNKTRNRRTRHYTTRTVFISLADDKIKSVDFPLHNVNDLERALLECVQPGSIIVMRDSFMERFGQQEEISNALFNHYKVKSICDVWPDFNERERNKQYIKTEMNQVPNVNQEPYAYEYFFRRCFADKCFNHLLRVIRLLYQK
Protein: I/LWEQ domain-containing protein (Q1ZXE9)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Clathrin light chain
- Clathrin heavy chain
- ANTH domain-containing protein
- Epidermal growth factor receptor substrate 15 homolog
- AP-2 complex subunit alpha-2
- AP-1 complex subunit beta
- AP-1 complex subunit gamma
- AP-2 complex subunit mu
- AP-2 complex subunit sigma
- AP-1 complex subunit mu
Sequence:
MTEFEAIVHKATNSKITAPKRKHVRSIVLECYNENSARTFYMELYRRPLDTSDVVCWKSLITIHKVVQEGPKNVLSDTISRVGWFENLRDHWARFDNRGFGRLVADYCTLIIDKIRFHQAHPEFDGGLSLENYSKNHRPESIEVDKGLQTVNRLMDLTDAVFRMHNSIVSATPYNDCKTSAFIPLVLESYAIYILVVHFLTNLIDKVDNKEVMDFSIKRFYGQYQTLRNFFLNASAITSVSSVIAVPNLPPDPPKFIRKVREAPKAKPQAIPPPVVKEPPTPPPEQIPVPVPTPVFIRQTVPVVYGAPYGMQQQQQDNSMWGQFGSNQPFDPNLQLQQQQAALLQQQQLQQQQLLQQQQLQQQLQQQQLLQQQQAAALAAAQQQQQQQQSPPQISPQSSAQWVTFGDDAPTRQRSTSTPPALEKKEASVDKPASPPKSTTASSNTDSQGKTRVITKIITKTVNNTQEINALKARIEELERLLQEEQDKNKALTLKLSEREAMIQEVTSARKRLQDMSSTNDNYTAEVVKQNEQLREQLIAIRDWTERTRLQRLEKEFGLAAGSIQQYLSQLDNPNNMGNQEATHQLVIEDLVNHLQQAQRLSDLCNQEGDDLEMDIFSAVNTVSNSLKSLFFDAKGSSRLILDPESQSKFMDAARKIGALTQNLFESIRLQGGQCNDDEDRKRLANNFASLKTGINNLDALAQQADAERIEAEKKYLENGFDLDDVAERELLAAAKTIEDAANSLLAAKSKRAPKKEGDSPDVAEAILEAAMAITGATSTLVGAATLAQRERVEKGRTSDGGPLYRKDPTWAEGLISAAKSVAQATKALVDNANKTASGQEIPGGTEEALIATSMAVTAATSQLVSACKSKSDINSPSQHKLSNAAKSVSNATNLLVAAAKAVAAKVASEEDIDFDKLTVTGYKVKEMEQQMAILRLEKELEVARKGLSVIRKKQYDENQ
Protein: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (Q5JPT9)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQFLLPLTQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGD