wanglab/gogpt-training-data huggingface dataset:
Protein: Transmembrane channel-like protein 2-B (F1QZE9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000255|RuleBase:RU310713}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU310713}. Note=Localized to the hair bundles of the hair cells. {ECO:0000269|PubMed:28534737}.
Interaction partners:
- LHFPL tetraspan subfamily member 5a.
- Transmembrane inner ear.
- Myosin VIb
- Protocadherin-15
- LHFPL tetraspan subfamily member 5b
- Si:dkey-205h13.2.
- Leucine-rich repeat-containing 51.
Sequence:
MCVLQLGWKWMQNLIVEVMWTQKEEQKAGINQNLRREEGKPNQQTVWRRAKKRRMNRRARGEAGGRSKKMRMRVRKNRREEERKLSIPGREQQRKTSQRRRSPSSCSSSSDNNSDDESMSEGEMARLKEEVEEKKKLIATLRNKPWRMKRRLKCLKEAQEFVEKFEGALGKGKGRRLYAFKVMMTKKLIKFNRDFENFKTACIPWESRIKEVESHFGSSVASYFIFLRWMYGLNLVLFGFMFGLVVIPELLMGIPYGSIPRKTVPREEQDSAMDFSVLFEFGGYCKYSILFYGFYNNQRTIGFLQFRLPLSYLLVGVGIFGYSLMVVIRTMARNANEGGDGGDEGNFTFCWKLFTSWDYLIGNPETADNKFASTTTSFKESIVDEQENLKDENIHLRRFLRLLANVLILCCLAGSGYLIYAVVKRSQDFAKRDRNELTWLQKNEVEIVMSLLGLVCPPLFEAIAELEDYHPRIALKWQLGRIFALFLGNLYTFLFALFDEVNGKLENEKQIKNQTVWALKEYYANYTLQYNITENIPPPNIAPADVIRGPCWETEVGIEFVKLTVSDIQVTYLTILIGDFLRALIVRFLNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGAFYAPGLVGINVLRLLSSMYYQCWAVMACNVPHERVFKASRSNNFYMGLLLLVLFLSLMPVIYSIMTLPPSFDCGPFSGKDKMYDVITETIDKDLPPFMADIFSYASNPGLIISVVLLMVWLAIYYLNAVSKAYQNSNLELKRKMQMQRDEEKNRRNNKDSTNQVMKDLEDLLPNKSLIPPPSVEETEKPAEQPSKSSKVTGKPGAAASGKGVHVQKDVSLAAANPRAPVTRAPGPRQPGPLPGNPRGPPPGQGMGRGRGGPPPRR
Protein: Actin-related protein 1 (Actin-like protein 1) (Actin-like protein 87C) (P45889)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Dynactin subunit 2
- Actin-related protein 10, isoform A
- CG9893 protein
- Dynactin subunit 6
- Dynactin subunit 4
- Dynactin subunit 5
- F-actin-capping protein subunit beta
- Dynactin subunit 1
- F-actin-capping protein subunit alpha
- Dynactin subunit 1
Sequence:
MEPYDVVVNQPVVIDNGSGVIKAGFAGEHIPKCRFPNYIGRPKHVRVMAGALEGDIFVGPKAEEHRGLLSIRYPMEHGIVTDWNDMERIWSYIYSKEQLATFTEDHPVLLTEAPLNPRRNREKAAEFFFEGINAPALFVSMQAVLSLYATGRVTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVTRYLKTLIRREGFNFRSTAEFEIVRSIKEKVCYLATNPQKEETVETEKFAYKLPDGKIFEIGPARFRAPEVLFRPDLLGEECEGIHDVLMYSIEKSDMDLRKMLYQNIVLSGGSTLFKGFGDRLLSELKKHSAKDLKIRIAAPQERLYSTWMGGSILASLDTFKKMWISKREYEEEGQKAVHRKTF
Protein: Lipid A biosynthesis lauroyltransferase (EC 2.3.1.241) (Kdo(2)-lipid IV(A) lauroyltransferase) (P0ACV0)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the transfer of laurate from lauroyl-[acyl-carrier-protein] (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). Has 10 fold selectivity for lauroyl-ACP over myristoyl-ACP. In vitro, can also catalyze a slow second acylation reaction leading to the formation of Kdo(2)-(dilauroyl)-lipid IV(A).
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01942, ECO:0000269|PubMed:1846149, ECO:0000269|PubMed:18656959, ECO:0000269|PubMed:8662613}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01942}.
Interaction partners:
- 3-deoxy-D-manno-octulosonic acid transferase
- Lipid-A-disaccharide synthase
- UDP-3-O-
- Tetraacyldisaccharide 4'-kinase
- UDP-3-O-acyl-N-acetylglucosamine deacetylase
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- Lipid A biosynthesis myristoyltransferase
- UDP-2,3-diacylglucosamine hydrolase
- Lipid A biosynthesis palmitoleoyltransferase
- Lipopolysaccharide heptosyltransferase 1
Sequence:
MTNLPKFSTALLHPRYWLTWLGIGVLWLVVQLPYPVIYRLGCGLGKLALRFMKRRAKIVHRNLELCFPEMSEQERRKMVVKNFESVGMGLMETGMAWFWPDRRIARWTEVIGMEHIRDVQAQKRGILLVGIHFLTLELGARQFGMQEPGIGVYRPNDNPLIDWLQTWGRLRSNKSMLDRKDLKGMIKALKKGEVVWYAPDHDYGPRSSVFVPLFAVEQAATTTGTWMLARMSGACLVPFVPRRKPDGKGYQLIMLPPECSPPLDDAETTAAWMNKVVEKCIMMAPEQYMWLHRRFKTRPEGVPSRY
Protein: Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137) (Q07011)
Organism: Homo sapiens (Human)
Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Subcellular location: Cell membrane; Single-pass type I membrane protein {ECO:0000305|PubMed:30872117}.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 9
- Tumor necrosis factor ligand superfamily member 4
- T-cell surface glycoprotein CD3 zeta chain
- CD70 antigen
- TNF receptor-associated factor 1
- T-lymphocyte activation antigen CD80
- Galectin-9
- T-cell-specific surface glycoprotein CD28
- ICOS ligand
- Ig-like domain-containing protein
Sequence:
MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL
Protein: Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361) (Q22795)
Organism: Caenorhabditis elegans
Function: Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched on hermaphrodite X chromosomes and during mitosis. Involved in dosage compensation by repression of X-linked gene expression in hermaphrodites. Plays a role in growth and body fat regulation downstream of the TOR complex 2 pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:12119097}. Chromosome {ECO:0000305|PubMed:23028348}.
Interaction partners:
- Histone-lysine N-methyltransferase Suv4-20
- Histone H4
- Retinoblastoma-binding protein homolog 5
- Multifunctional procollagen lysine hydroxylase and glycosyltransferase
- Dosage compensation protein dpy-30
- 1-phosphatidylinositol 4-kinase
- Proliferating cell nuclear antigen
- WD repeat-containing protein wdr-5.1
- Host cell factor homolog hcf-1
- Set1/Ash2 histone methyltransferase complex subunit ash-2
Sequence:
MKVAAKKLATSRMRKDRAAAASPSSDIENSENPSSLASHSSSSGRMTPSKNTRSRKGVSVKDVSNHKITEFFQVRRSNRKTSKQISDEAKHALRDTVLKGTNERLLEVYKDVVKGRGIRTKVNFEKGDFVVEYRGVMMEYSEAKVIEEQYSNDEEIGSYMYFFEHNNKKWCIDATKESPWKGRLINHSVLRPNLKTKVVEIDGSHHLILVARRQIAQGEELLYDYGDRSAETIAKNPWLVNT
Protein: V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) (P21283)
Organism: Homo sapiens (Human)
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5FVI6}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q5FVI6}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit H
- V-type proton ATPase subunit B, brain isoform
- V-type proton ATPase subunit F
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase subunit E 1
- V-type proton ATPase subunit D
- V-type proton ATPase 16 kDa proteolipid subunit c
- V-type proton ATPase 21 kDa proteolipid subunit c''
- Renin receptor
Sequence:
MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKTLKKLREVLHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme A) (Q8IQF9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTSTAAANLLKTVEETFSGYNSGDEHHQPKERLIPVEEWQRRDLEFAKCMEQRGYELKPVEEDGACLFRSISLQIYGDEEMHDVIRQHTMDYIHENREYFGQFVTEDINSYIQRKRARDAHGNHIEIQAISEIYSRTVEVYCYQSNPINIFNSEQSQAGYPPLRLSYQRGSHYNAILDPYNATVGVGLGLAGYKPEIQTKEAVRLSEQLEIEQTMFEDKLKTTDWEATNEAIEEQIARESYLQWCRENTQRSRNSNTAAGSATSSTVTSAEALTDSDASPSKYSACGGTGSSGNPPVALTSGSGGDGAGPAFSLSPKTLNQFSHKLPQEVNELGGYDSDATDMSSTSSVGHSGGSSSPSTAASQRSGKGSKSQRRATALRKKRRHETRETTLASKSAEALEAPLRKSPKRDSAPSVARADTPEAEQRPSTSKQSSHSPQKNVDSKSPTEQSYSSFYQELLEASYANEGANESEMLQQAIQMSTRDYMEDQKRKFLFGP
Protein: Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II)] (P04638)
Organism: Rattus norvegicus (Rat)
Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P02652}.
Interaction partners:
- Apolipoprotein C-III
- Apolipoprotein E
- Apolipoprotein B-100
- Apolipoprotein C-I
- Beta-2-glycoprotein 1
- Apolipoprotein A-I
- Apolipoprotein A-IV
- Serum paraoxonase/arylesterase 1
- Apolipoprotein C-II
- Apolipoprotein D
Sequence:
MKLLAMVALLVTICSLEGALVRRQAAETDVQTLFSQYLQSLTDYGKDLMEKAQPSEIQNQAKAYFQNAQERLTPFVQRTGTNLMDFLSRLMSPEEKPAPAAK
Protein: At3g18870 (Mitochondrial transcription termination factor family protein) (Q9LHN2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mitochondrial transcription termination factor family protein
- Mitochondrial transcription termination factor family protein
- Mitochondrial transcription termination factor-related / mTERF-like protein
Sequence:
MAVIASLHHLQPLSSFSSPPSPSSSKPLYLKFQTSHRENLRHLSSLGIVPQNPRLAPPANDLSVILSAVNLLKSKGISDEDFPRLVFLCPQLFSPTFDISKLDPVFDFLTGELGASAEESRGLIVNCPNILFSDVEYCLRPTLVYLKELGVRNLNRASKTNAHVLNTRVEKLRAKMRFLKSIGFEHEEAARVCGRIPAIFGYSVEDNLRPKFEFLVYDMERELEELKKFPQYFAFSLGKRIRPRHWHLKKKNVRVSLSRMLMWGDQKFYSKWKP
Protein: X-box-binding protein 1 (F7BMG3)
Organism: Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Interaction partners:
Sequence:
MPFSNVKVMMPVLPKPDHASSGRMQENIPLSAIEDKELRKKLRNRQSALAARERKKARMMELEKQVAELQETNRRMEDENQHLRARLDNIIQRCLRAGFPLDGSADTAWMRVNAEAQDYSRRQVGYAHPTAAGQSLQNQQLRMAQPTGERITEASLKCAIRALGERQHEILQTITSGIMAPIQPAAAKYDAQLCYQQQSFKVSPAQSPVTVKQEYGTSSQTYSPQNQETVPLPQSSCSAESPVISNGTNRLLEPAHSSPCKRDWLTANQTLPSIGAMLAPSAKRPCSRSNEHQPVDNTELEKCSPTNNVGFLMRSENPPRPVNVINSINSPPTVITSNPQNEKVKSPQSYLEPTENTISSCSPSPLLTQGEDFLAGEFDNIIEEENTNQCGLTIFDIEEIIRGDSCADSPSARSGSDSGLSMDESLDWIADNPIFNF
Protein: Biliverdin reductase B (A0A8I5ZUN1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAVKKIAIFGATGRTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPQPAHVVVGDVLQAGDVDKTVAGQDAVIVLLGTGNDLSPTTVMSEGTRNIVAAMKAHGVDKVVACTSAFLLWDPSKVPPRLQDVTDDHIRMHKILEESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTHEYDGQKTYPSHQAGGRTQGLALPR
Protein: Uncharacterized protein (Q389N9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNPEAPPFFPTFALAHSHRRVYSRAELKRIELSVVESIRRAPRTGVPSASALPVDFAALFARLPHAHEVLDVEHVAKLVEDGREPVDGTRALIEGNRQPLCPECANGPEACEEVRGIVAGAVRRAASNRLSAVLLQSGNVVWGLIQLTLVFEAKQSSLRLRVLAERHPNIVSLIREYLCGEGYHLPLPKITEHKQWQELNSILKFDWIRDNRTRVFTEISRRWKQRHTQFEQFVHFFGYRDAKPQHQVKNMLTNCAKPVFISILSGDIVAVVLLARLEFFVPPDYYWDIFPYFAETLLKKGSDGKTYAVMRHLCQHFHERQQSLRKDVYNPIEPPRRR
Protein: Bifunctional pinoresinol-lariciresinol reductase 2 (PLR-Lu2) ((+)-lariciresinol reductase) (EC 1.23.1.2) ((+)-pinoresinol reductase) (EC 1.23.1.1) (E6Y2X0)
Organism: Linum usitatissimum (Flax) (Linum humile)
Function: Reductase involved in lignan biosynthesis. Catalyzes the enantioselective conversion of (+)-pinoresinol into (+)-lariciresinol and of (+)-lariciresinol into (-)-secoisolariciresinol. Abstracts the 4R-hydride from the NADPH cofactor during catalysis.
Interaction partners:
Sequence:
MAAGFLFHMGSLPAIATVGHKSKVLVIGGTGYLGKRLVTASLAAGHETYVLQRPEIGVDIEKIQLLLSFKKAGASLVSGSFNDYRSLVDAVKLVDVVICAVSGVHIRSHQILLQLKLVDAIKEAGNVKRFLPSEFGTDPATMENAMEPGRVTFDDKMVVRKAIEEAGIPFTYISANCFAGYFLGGLCQPGFILPSREQVTLLGDGNQKAVYVDEDDIARYTIKMIDDPRTLNKTVYIKPPKNVLSQREVVGIWEKYIGKELKKTTLSVEEFLAMMKEQDYAEQVGLTHYYHVCYEGCLTNFEIGDEAGEATKLYPEVGYTTVVEYMKRYV
Protein: Tektin-2 (Tektin-t) (Testicular tektin) (Q922G7)
Organism: Mus musculus (Mouse)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:15340058}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:10456331, ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:24394471}. Note=Colocalized with CCDC172 at the perinuclear region (PubMed:24394471). {ECO:0000269|PubMed:24394471}.
Interaction partners:
- Homeobox protein goosecoid
- EF-hand domain-containing protein 1
- Tektin-4
- Tektin-1
- Tektin-3
- EF-hand domain-containing family member C2
- RIB43A-like with coiled-coils protein 2
- Parkin coregulated gene protein homolog
- Cilia- and flagella-associated protein 45
- Protein Flattop
Sequence:
MATLSFKPSERYRLSDWRTNSYLLSTNAERQRDASHQIRQEARILRNETNNQIVWDEHDNRTRLAERIDTVNRWKETLDKCLTDLDAEIDSLAQAKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVRDPVEEELLKEVEVIEATKKVLQEKISQAFQHLCLLQEIRQQLNSDHRDKMETLEIDRGCLSLNLTSPNISLKVNPTRIPKDSTTLQQWDEFTRFNKNRAEAEMKASIELREAIALAIAQTNNELDAQRVATEFTFRKRLREMESFYSELKWQEKNTLEEIAELQGDIRRLEEDLRRKMMNLKLAHTRLESRTYRSNVELCRDQTQYGLIDEVHQLEATINTMKQKLAQTQNALDALFKHLARIQADIACKTNTLLLDTKCMDTRRKLTVPAEKFVPQVDTFTRTTNRTLSPLKICQLELT
Protein: Transcription factor Sox-7 (Q28GD5)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Transcription factor. Binds to the DNA sequence 5'-AACAAT-3'. Acts downstream of vegt and upstream of nodal signaling to promote endodermal and mesodermal differentiation by promoting vegt-induced expression of both endodermal genes (including endodermin) and mesodermal genes (including snai1/snail and snai2/slug). Induces expression of multiple nodal genes (including nodal, nodal2, nodal4, nodal5 and nodal6) and binds directly to sites within the promoter of the nodal5 gene. The endodermal and mesodermal specification pathways then interact to initiate cardiogenesis. Acts partially redundantly with sox18 during cardiogenesis. Also acts as an antagonist of beta-catenin signaling (By similarity). Regulates (possibly indirectly) development of the pronephros, the functional larval kidney.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O42342, ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
Sequence:
MTTLMGSYSWTEGLDCSPIDEDLSDGLSPHRSPREKGSETRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALSPAQKRPYVEEAERLRVQHMQDYPNYKYRPRRKKQIKRICKRVDTGFLLSSLSRDQNSVPDTRGCRTAVEKEENGGYPGSALPDMRHYRETPSNGSKHDQTYPYGLPTPPEMSPLEAIDQDQSFYSTPCSEDCHPHINGAVYEYSSRSPILCSHLSQVPIPQTGSSMIPPVPNCPPAYYSSTYHSIHHNYHAHLGQLSPPPEHPHYDAIDQISQAELLGDMDRNEFDQYLNTSLHDPSEMTIHGHVQVSQASDIQPSETSLISVLADATATYYNSYSVS
Protein: Dachshund homolog 1 (Dach1) (Q9QYB2)
Organism: Mus musculus (Mouse)
Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity). Binds to chromatin DNA via its DACHbox-N domain.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mothers against decapentaplegic homolog 4
- Protein phosphatase EYA1
- Homeobox protein SIX1
- Homeobox protein SIX6
- Protein phosphatase EYA3
- Protein phosphatase EYA2
Sequence:
MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASSASSSAAATVTSPGGGGGGSGGGGGSGGNGGGGGSNCNPSLAAGSSGGGVSAGGGGASSTPITASTGSSSSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNASSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATNAAIAEAMKVKKIKLEAMSNYHASNNQHGADSENGDMNSSVGSSGGSWDKETLHSPPSQGSQAPVAHARMPAAFSLPVSHPLNHLQHSHLPPNGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRIHIEKDETPLSTPTARDSIDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASADSLRVLNDSLTPEIEADRSGGRADAERTIQDGRLYLKTTVMY
Protein: Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) (Q9JIL4)
Organism: Mus musculus (Mouse)
Function: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (By similarity). Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
Subcellular location: Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ40}. Cell membrane {ECO:0000269|PubMed:11051556, ECO:0000269|PubMed:16141316}. Note=Localized in the brush border membrane of renal proximal tubule cells (PubMed:11051556, PubMed:16141316). Associated with peripheral membranes (By similarity). Localizes to the apical compartment of proximal cells and to sinusoidal liver membranes (By similarity). {ECO:0000250|UniProtKB:Q9JJ40, ECO:0000269|PubMed:11051556, ECO:0000269|PubMed:16141316}.
Interaction partners:
- Sodium-dependent phosphate transport protein 2A
- Sodium/hydrogen exchanger 3
- Cystic fibrosis transmembrane conductance regulator
- Chloride anion exchanger
- A-kinase anchor protein 10, mitochondrial
- Ezrin
- PDZK1-interacting protein 1
- Sodium-dependent phosphate transport protein 1
- Scavenger receptor class B member 1
- Na
Sequence:
MASTFNPRECKLSKQEGQNYGFFLRIEKDTDGHLIRVIEEGSPAEKAGLLDGDRVLRINGVFVDKEEHAQVVELVRKSGNSVTLLVLDGDSYEKAVKNQVDLKELDQSQREAALNDKKPGPGMNGAVEPCAQPRLCYLVKEGNSFGFSLKTIQGKKGVYLTDIMPQGVAMKAGVLADDHLIEVNGENVENASHEEVVEKVTKSGSRIMFLLVDKETARCHSEQKTQFKRETASLKLLPHQPRVVVIKKGSNGYGFYLRAGPEQKGQIIKDIEPGSPAEAAGLKNNDLVVAVNGKSVEALDHDGVVEMIRKGGDQTTLLVLDKEAESIYSLARFSPLLYCQSQELPNGSVKEGPAPIPAPLEATGSEPTEDAEGHKPKLCRLLKEDDSYGFHLNAIRGQPGSFVKEVQQGGPADKAGLENEDVIIEVNGENVQEEPYDRVVERIKSSGKHVTLLVCGKMAYSYFQAKKIPIVSSMAEPLVAGPDEKGETSAESEHDAHPAKDRTLSTASHSSSNSEDTEM
Protein: Uncharacterized protein IRC4 (Increased recombination centers protein 4) (Q03036)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Putative increased recombination centers protein 14
- Increased recombination centers protein 19
- Uncharacterized protein IRC9
- Uncharacterized protein YPL245W
- Putative cystathionine beta-lyase
Sequence:
MREYTSKKELKEEIEKKYEKYDAEFETISESQKDEKVETVDRTPSENLSYQLGWVNLLLEWEAKEIAGYNVETPAPGYKWNNLGGLYQSFYKKYGIYSIKEQRAKLREAVNEVYKWISTLSDDELFQAGNRKWATTKAMWPVYKWIHINTVAPFTNFRGKIRKWKRLVPEEQRIKRRKI
Protein: Transcription factor MYB118 (Myb-related protein 118) (AtMYB118) (Protein PLANT GROWTH ACTIVATOR 37) (Q9LVW4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that recognizes the motif 5'-TAACGG-3' in the promoter of endosperm-induced genes. Promotes vegetative-to-embryonic transition and the formation of somatic embryos from root explants in a WUS-independent manner but via the expression of embryonic genes (e.g. LEC1, LEC2, FUS3 and WUS). May play an important role during embryogenesis and seed maturation. Together with MYB115, activates the transcription of S-ACP-DES2/AAD2 and S-ACP-DES3/AAD3 thus promoting the biosynthesis of omega-7 monounsaturated fatty acid in seed endosperm. Regulates negatively maturation genes in the endosperm.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:19066902, ECO:0000269|PubMed:27681170}.
Interaction partners:
- B3 domain-containing transcription factor LEC2
- Nuclear transcription factor Y subunit B-9
- B3 domain-containing transcription factor FUS3
- Agamous-like MADS-box protein AGL15
- Nuclear transcription factor Y subunit B-6
- Protein WUSCHEL
- Stearoyl-[acyl-carrier-protein] 9-desaturase 3, chloroplastic
- Stearoyl-[acyl-carrier-protein] 9-desaturase 2, chloroplastic
Sequence:
MEFESVFKMHYPYLAAVIYDDSSTLKDFHPSLTDDFSCVHNVHHKPSMPHTYEIPSKETIRGITPSPCTEAFEACFHGTSNDHVFFGMAYTTPPTIEPNVSHVSHDNTMWENDQNQGFIFGTESTLNQAMADSNQFNMPKPLLSANEDTIMNRRQNNQVMIKTEQIKKKNKRFQMRRICKPTKKASIIKGQWTPEEDKLLVQLVDLHGTKKWSQIAKMLQGRVGKQCRERWHNHLRPDIKKDGWTEEEDIILIKAHKEIGNRWAEIARKLPGRTENTIKNHWNATKRRQHSRRTKGKDEISLSLGSNTLQNYIRSVTYNDDPFMTANANANIGPRNMRGKGKNVMVAVSEYDEGECKYIVDGVNNLGLEDGRIKMPSLAAMSASGSASTSGSASGSGSGVTMEIDEPMTDSWMVMHGCDEVMMNEIALLEMIAHGRL
Protein: Carboxypeptidase B (CPBHz) (EC 3.4.17.2) (Q3T905)
Organism: Helicoverpa zea (Corn earworm moth) (Heliothis zea)
Function: Metalloprotease which cleaves a single amino acid from the C-terminal end of polypeptide chains. Shows a strong preference for peptides with a terminal lysine residue.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MKFLLVLALCAVVYAKHEAYIGWKSYYVGVATDAQAKALEPLIQKYELDFLSHPTKSREGVVLVKPQHQAGFVQDIEAGGITYRIHADDVKRQLEFDDQLIEMQRMSSFTRTAGRQLPYDNYQELEVIDEYLDYIGEKYPDVATVVNAAESFEGRPIKYIKISTTNFEDENKPVIFIDGGIHAREWISPPSVTWAIHKLVEDVTENDLLEKFDWILLPVVNPDGYKYTFTNERFWRKTRSTNNNPLSQICRGADGNRNFDFVWNSIGTSNSPCSDIYAGTSAFSEVETRVVRDILHEHLARMALYLTMHSFGSMILYPWGHDGSLSQNALGLHTVGVAMASVIQSNALPNFPPYTVGNSALVIGYYIAGSSEDYAHSIGVPLSYTYELPGLSSGWDGFHLPPQYIEQVCRETWEGIVVGARRAGDLFRK
Protein: Protein RESPONSE TO LOW SULFUR 2 (Protein ENHANCED DE-ETIOLATION 6) (Q9FIR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in defense responses monitoring. Probably implicated into osmotic stress signaling.
Interaction partners:
- Protein SULFUR DEFICIENCY-INDUCED 1
- Protein SULFUR DEFICIENCY-INDUCED 2
- Hydrolase-like protein family
- 5'-adenylylsulfate reductase 2, chloroplastic
- Berberine bridge enzyme-like 18
- Beta-glucosidase 28
- 5'-adenylylsulfate reductase 3, chloroplastic
- Thiamine phosphate phosphatase-like protein
- Protein RETICULATA-RELATED 3
Sequence:
MGKGGNYVTVAASEVDELRRKNGEMEKAVEEMKKEMLQLWRRTQVAEEAEERLCSQLAELEAESLDQARDYHSRIIFLMNELSRLSSDSASASP