wanglab/gogpt-training-data huggingface dataset:
Protein: Counting factor associated protein D (Q54TR1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Inhibitor that slows proliferation of secreting cells (also known as chalone). Requires aprA for activity.
Subcellular location: Secreted {ECO:0000269|PubMed:18611962, ECO:0000269|PubMed:19187549}. Note=Concentrated in subcellular structures, possibly vesicles.
Interaction partners:
- Autocrine proliferation repressor protein A
- Probable basic-leucine zipper transcription factor N
- Battenin
- Guanine nucleotide-binding protein alpha-8 subunit
Sequence:
MNKFILLLSLVTLSCVLAVPQLPAAQQYYMKGSFNIPYFNIVEPIELIYDSVNNRQYISVYNGMDITINFYNQDNTYNVGPVKYDMVCTTTPGNGSLVNVLPTEPSSWVYNGTSTVNGVQVFGYSQKITQYGRTGFYNFYVDANGVPVQFYMDGVDYVFGSHPDVYVLNFDIYTTDISSYESYFDIPVLCNNAKEAPAKENQFDGLFSSIGDNLLAKEEQASNLFKEYKAQYNKEYSSQDEHDERFINFKAARKIIATHNAKESSYKLGMNHYADLSNKEFNTLVKPKVARPSVTGADSVHDDESLRSIPSTVDWRNQNCVTPVKDQGICGSCWTFGSTGSLEGTNCVTNGELVSLSEQQLVDCAILTGSQGCGGGFASSAFQYVMEIGSLATESNYPYLMQNGLCRDRTVTPSGVSITGYVNVTSGSESALQNAIATTGPVAIAIDASVDDFRYYMSGVYNNPACKNGLDDLDHEVLAIGYGTYQGQDYFLVKNSWSTNWGMDGYVYMARNDNNLCGVSSQATYPIPTKN
Protein: Syntaxin (Q384W2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSEELRWQHIPEVLRNVALMSRNHNYSGKDKNGCEDANHVEQGALATVSQLLERTRELRELFVQVVEVTTTPVDEDSAVTASFATQQKVIALGRHVALLQSEIRAKNLQCARVALRAYLASEVDSRRRTLARMQAALSIAKQSI
Protein: Homeobox protein Hox-A2 (Homeobox protein Hox-1.11) (Hox1.11) (P31245)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-A5
- Homeobox protein Hox-A3
- Roundabout homolog 2
- Homeobox protein Hox-A4
- Homeobox protein Hox-D10
- Pre-B-cell leukemia transcription factor 1
- Homeobox protein Hox-B5
Sequence:
MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRHGAGVGGRPKSSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTALPPAAASTGPACLGHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKFKNLEDSDKVEEDEEEKSLFEQALSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQTFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSPEAIEVPSLQDFNVFSTDSCLQLSDALSPSLPGSLDSPVDISADSFDFFTDTLTTIDLQHLNY
Protein: CD4-1 molecule (CD4-1 protein) (F1QZB1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Major histocompatibility complex class II integral membrane beta chain gene.
- Major histocompatibility complex class II DAB gene
- Uncharacterized protein LOC103911540 precursor
- H-2 class II histocompatibility antigen, A-U alpha chain
- Si:busm1-194e12.8.
- Si:busm1-228j01.4.
- Tyrosine-protein kinase
- CD8 antigen, alpha polypeptide
- Novel protein similar to MHC class II alpha chain
- Major histocompatibility complex class II DAA precursor
Sequence:
MLGLILIPLFITVLKAQESHEVIYAQVGGTVTLPREKIERKYSNIKTQDIYVNWFLESTLTINRNPQSSSSKGTNTRVSLSADFSLQISPVEESDFVIWRCVQHVLAGNYEKTYKLYKVSIPKVPALLVGGRLSLKYVKDVSSVNPSVTWISPKNEGCQENKNTKDTVLVPSVSTCHNGVWTCQLKYGNKKTEATTTVSVIDLAPSPADPIYTSISQSSTVSIPCALSSAIPWSVLNETLQGGSWSFTPLSEPRSPLSLLTLNVGSVVRWDLANGANFTDGKRVITNHNLSIQNLPVKETIRGVYKCSLKFNTKTISREVKVEVLKVSPSGILKVFEGTRLNVTCSLGHMNTAGLEVKWACASNCPPFNHKSPPHLSVLSFPNIRMQDKGLVKCELWKNSQKLTSAQLYLRVEKAPVDIWLCVAIGSGVVVFILLVAFAIIYIRRHKQMMMYRRRKTRFCCCNNNKQPKGFYKT
Protein: Uncharacterized protein (Q38C38)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFRGSGARKCCSSSFLYRTAPTSAATGTSPPSLVTVPLLRAALLLRWRLLSLQFDGDSNMCVLAEDAADGLPRGTRLEMYGSNVQLVRQLSGAGEALLQPSVIGEVTATLEGALTDDTTERRGRQIVAVLSPPHLSSSLGGPEFKGNEDVEVIAQWTLSRKRVENVQRVTDTTKRDGVKNEEPPPLMENGIVFPSPRFAGLRVLRAARHSFALLLENELRERTGESEVGKVGPLAVLDVSELDCTFSRVAVQMAVERGLVLEQHMHVNFVPLTPAATATADETVRSLLRLVAHPTRGAHLDPLRPLQARCFKLGCCTFCSKGRGSAANEGSKKDEASLVSRLAGVISKIHSNGTLLVNLVGDGINHEELRQGAEMHLVEALLRADRCGVVIDEVLPAADTRGTAISFVVSLC
Protein: GDSL esterase/lipase EXL3 (EC 3.1.1.-) (Family II extracellular lipase 3) (Family II lipase EXL3) (Q94CH6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Transmembrane protein
- CAP superfamily protein
- Protein ORGAN SIZE RELATED 1
Sequence:
MKDNSSWSCSCSWSSWKICLLSVLFLTETITAVKLPPKLIIPAVIAFGDSIVDTGMNNNVKTVVKCDFLPYGINFQSGVATGRFCDGRVPADLLAEELGIKSIVPAYLDPNLKSKDLLTGVSFASGGSGYDPITPKLVAVISLEDQLSYFEEYIEKVKNIVGEARKDFIVANSLFLLVAGSDDIANTYYTLRARPEYDVDSYTTLMSDSASEFVTKLYGYGVRRVAVFGAPPIGCVPSQRTLGGGILRDCADNYNEAAKLFNSKLSPKLDSLRKTLPGIKPIYINIYDPLFDIIQNPANYGFEVSNKGCCGTGAIEVAVLCNKITSSVCPDVSTHVFWDSYHPTEKTYKVLVSLLINKFVNQFV
Protein: Tubulin epsilon chain (Epsilon-tubulin) (Q9D6T1)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9UJT0}. Note=Associated with pericentriolar material. {ECO:0000250|UniProtKB:Q9UJT0}.
Interaction partners:
- Centriolin
- Ninein
- Tubulin delta chain
- Outer dense fiber protein 2
- Centrosomal protein of 170 kDa
- WD repeat-containing protein 90
- Tubulin epsilon and delta complex protein 2
Sequence:
MTQSVVVQVGQCGNQIGCCFWDLALREHAAVNQKGIYDDAISSFFRNVDTRAVGDGGSISKGRISSLKARAVLIDMEEGVVNEILQGPLRDVFDSKQLITDISGSGNNWAVGHKVFGCLYREQILEKLRKSAEQCDCLQCFFIIHSMGGGTGSGLGTFLLKVLEDEFPEVYRFVTAVYPSSEDDVITSPYNSMLAMKELNEHADCVLPIDNQSLFDIISKIDLVVNSGKLGSAVKPKSLITSNMGAVKKHHKKPFDAMNNIVANLLLSLTSSARFEGSLNMDLNEISMNLVPFPKLHYLVSSLTPLYTLADVNIPPRRLDQMFSDAFSKDHQLIQADPRHSLYLACALIVRGNVQISDLRRNIERLKPALQFVSWNQEGWKTSLCSVPPVGHSHSLLALANNTCVKPTFMELRERFTRLYKKKAHLHHYLQVDGMEESTFTEAVSSLSALIQEYSDLDATKSLPVPDVPRLSVAL
Protein: Vermiform, isoform I (E1JI40)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Gasp, isoform A
- LD43683p
- FI03450p
- Knickkopf
- Uninflatable, isoform C
- Chitin deacetylase-like 4
- BcDNA.GH02976
- chitin synthase
- Chitinase 7
Sequence:
MARWWPILSVVCLCLAVDGLYVKNSFEPAIDQDPSRRYQRKPHGQDKLEGVDVEEVCADRPADEYFRLETDGDCREVYRCDSAGEDGTWRLAPIRCAGGLAFDVLRQLCDWKSNVKSCDVLEKPRKAKPILKTDEPICPEGKLSCGDGECLDKELFCNGKSDCKDESDENACSVDEDPNRAPECDPTQCALPDCFCSADGTRIPGGIEPQQVPQMITITFNGAVNVDNIDLYEDIFNGQRQNPNGCSIKGTFFVSHKYTNYSAVQDLHRRGHEISVFSLTHKDDPNYWTGGSYDDWLAEMAGSRLIVERFANITDGSIIGMRAPYLRVGGNKQFEMMADQFFVYDASITASLGRVPIWPYTLYFRMPHKCNGNAHNCPSRSHPVWEMVMNELDRRDDPTFDESLPGCHMVDSCSNVASGDQFARLLRHNFNRHYNSNRAPLGLHFHASWLKSKKEYRDELIKFIEEMLGRNDVFFVTNLQVIQWMQNPTELNSLRDFQEWKEKCDVKGQPYCSLPNACPLTTRELPGETLRLFTCMECPNNYPWILDPTGDGFSV
Protein: Glutathione reductase, chloroplastic (GR) (GRase) (EC 1.8.1.7) (Protein EMBRYO DEFECTIVE 2360) (P42770)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Maintains high levels of reduced glutathione in the chloroplast.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione synthetase, chloroplastic
- Glutathione S-transferase DHAR2
- Probable glutathione peroxidase 3, mitochondrial
- Probable glutathione peroxidase 2
- Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial
- Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic
- Probable glutathione peroxidase 4
- Probable glutathione peroxidase 5
- Putative glutathione peroxidase 7, chloroplastic
Sequence:
MASTPKLTSTISSSSPSLQFLCKKLPIAIHLPSSSSSSFLSLPKTLTSLYSLRPRIALLSNHRYYHSRRFSVCASTDNGAESDRHYDFDLFTIGAGSGGVRASRFATSFGASAAVCELPFSTISSDTAGGVGGTCVLRGCVPKKLLVYASKYSHEFEDSHGFGWKYETEPSHDWTTLIANKNAELQRLTGIYKNILSKANVKLIEGRGKVIDPHTVDVDGKIYTTRNILIAVGGRPFIPDIPGKEFAIDSDAALDLPSKPKKIAIVGGGYIALEFAGIFNGLNCEVHVFIRQKKVLRGFDEDVRDFVGEQMSLRGIEFHTEESPEAIIKAGDGSFSLKTSKGTVEGFSHVMFATGRKPNTKNLGLENVGVKMAKNGAIEVDEYSQTSVPSIWAVGDVTDRINLTPVALMEGGALAKTLFQNEPTKPDYRAVPCAVFSQPPIGTVGLTEEQAIEQYGDVDVYTSNFRPLKATLSGLPDRVFMKLIVCANTNKVLGVHMCGEDSPEIIQGFGVAVKAGLTKADFDATVGVHPTAAEEFVTMRAPTRKFRKDSSEGKASPEAKTAAGV
Protein: E2F transcription factor 3 (F4ILT1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU003796}.
Interaction partners:
Sequence:
MSGVVRSSPGSSQPPPPPPHHPPSSPVPVTSTPVIPPIRRHLAFASTKPPFHPSDDYHRFNPSSLSNNNDRSFVHGCGVVDREEDAVVVRSPIFPSEIGLEIRGCFGDFDCYLLLLSLIQKLRSVRLSSIRVNFCRLFSFAMSRKRKATMDMVVAPSNNGFTSSGFTNIPSSPCQTPRKGGRVNIKSKAKGNKSTPQTPISTNAVRSFYEISFMSRVTSLLTKKFVNLIKQAKDGMLDLNKAAETLEVQKRRIYDITNVLEGIDLIEKPFKNRILWKGVDACPGDEDADVSVLQLQAEIENLALEEQALDNQIRWLFVTEEDIKSLPGFQNQTLIAVKAPHGTTLEVPDPDEAADHPQRRYRIILRSTMGPIDVYLVSEFEGKFEDTNGSGAAPPACLPIASSSGSTGHHDIEALTVDNPETAIVSHDHPHPQPGDTSDLNYLQEQVGGMLKITPSDVENDESDYWLLSNAEISMTDIWKTDSGIDWDYGIADVSTPPPGMGEIAPTAVDSTPR
Protein: Calcium-transporting ATPase, putative (EC 3.6.3.8) (Q389H9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MRGESSAVSFQYESPDVTGASPSFTNSSLARIIGQKELPRFGIEIGGHEGLLKLLGVRYDGEPTWRSGGGLRGGILSDSVHQRRCRFGGNRLPRPRDKSVGTLVKESIEEDKILQLLIGAALFSILLGHLTSYHQKEGGNMCPSWVEGAAILFSVVVVVTLGALNNYNKQKQFSHVLLQEDGTRQSIVVWRYDTLDDRAMVRELCLAAREVPSEDLVVGDVVQISSGMELSFDAILFGGNYVVCDECCVSGESEEVVKSLEADPFLISGSSVLEASSEAIAVVCAVGEKSFSGEIAMAVRDTEKKVTPLQEHLSVMADHIGKFGLAVAVLTFVVLFLKEVYEVVAMGKPFFVMSFVENLATSIAIIVVAVPEGLPLSVTISLAYSMRYMLRDGNLVRHLAACETMGSATVLCTDKTGTLTSPHATLSRVLFEGKVYTANDSGGDGSSCVEGGRWNKSGTGLFVVASSQATAGLLMECVVSNALDPVRGRPVNRTAEALLQLAQHLYVSCGDDFSSPFVYDMGRLAQQMCDGSRCVRFPFTSVQKKSVTILKLPTGELRQYVVGAPEAILSSCRNFITAAGALVEINTESREFLQSIIQEFGRRGLRSLCCAYAVVYPIEGRIMPLEVSSAPLNFLAAVALEEEVRPEVPAAVRASICAGIRVIMVTGDGLLTSINIAYRCGLLNPVGGETSNCFSPPPISTLINDGYAMDGPAFRACSDTDLLVNYIPKLCVLARATPLDKKRVLQLLKMHDPLAVIAVTGDGTNDAPALKLSDVGFAMNSGSEVAKRASDIILLHDNFAGMVKATMWGRNVRDNVRKFLQFQLTVNCVACVFAFCGALINESNILPLKPVQLLWLNLIMDTLASLALATELPLEKRLFDRAPEPRDTPIILPGMLFQVAVQGGYQFVVQIYMLLAGHRLFGDSSTGEVERRSRPPIDYLCPKHLSIVFNVFVLMQVMNFFNARLLHEEDSFFENWGSSRLLLLIVAVIAVLQVCIVQYGGRFMSTVPLSTEEWLYCTLYASGSLAVGAASRFCWRWMRRRGAHSTGSCDSYVLLSYLPRWLRALIDGARGGSGRRRQRSSYCKAAVKGKGACKTAPAYV
Protein: Pleckstrin homology domain-containing family F member 1 homolog (PH domain-containing family F member 1 homolog) (Protein rush hour) (O76902)
Organism: Drosophila melanogaster (Fruit fly)
Function: Functions in the regulation of endosome morphology and late endosome formation. Has a role in controlling trafficking from early to late endosomes and from late endosomes to lysosomes. Important for localization of Gdi to the endosomal membranes. May function in controlling the activity of multiple regulators in the endocytic pathway, perhaps by positively controlling those involved in the early steps of endocytosis such as Rab5 and hrs, and negative regulating those involved in the late stages of endocytosis like car and VhaSFD.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:22160599}. Endosome membrane {ECO:0000269|PubMed:22160599}. Cytoplasm, cell cortex {ECO:0000269|PubMed:22160599}.
Interaction partners:
Sequence:
MVDRLVNSEANTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYGNIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCVEDLLRKSGKKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKALRVCDACYERLKHVPSSLGSGEDSAAATGAASGNKLNTTAGDSSNDEDSDEETASPGGESHDEPRFYGDNSVLSAVEDSSTITSPSSATTGSLEAPQVTPSVQSSPAAVATTGSHC
Protein: GrpE protein homolog 1, mitochondrial (HMGE) (Mt-GrpE#1) (Q9HAV7)
Organism: Homo sapiens (Human)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:11311562}.
Interaction partners:
- Stress-70 protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM44
- 10 kDa heat shock protein, mitochondrial
- Mitochondrial disaggregase
- 60 kDa heat shock protein, mitochondrial
- Heat shock 70 kDa protein 4
- DnaJ homolog subfamily B member 1
- Mitochondrial import inner membrane translocase subunit Tim17-A
- Mitochondrial import inner membrane translocase subunit Tim10
- ATP-dependent Clp protease proteolytic subunit, mitochondrial
Sequence:
MAAQCVRLARRSLPALALSLRPSPRLLCTATKQKNSGQNLEEDMGQSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKEA
Protein: Uncharacterized NOP5 family protein MJ0694 (Q58105)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Interaction partners:
- Large ribosomal subunit protein eL8
- Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
- Probable tRNA pseudouridine synthase B
- Small ribosomal subunit protein eS6
- KH domain-containing protein MJ0443
- Ribosomal RNA small subunit methyltransferase Nep1
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein eS1
- Uncharacterized protein MJ1408
Sequence:
MIYVTFTPYGAFGVKDNKEVSGLEDIEYKKLFNEEEIPDIMFKLKTQPNKIADELKEEWGDEIKLETLSTEPFNIGEFLRNNLFKVGKELGYFNNYDEFRKKMHYWSTELTKKVIKSYAQQKDKIIIQVAEAISDLDKTLNLLSERLREWYSLYFPELDHLVNKHEVYANLITKLGKRKNFTKSQLKKILPSKLAGKIAEAAKNSMGGELEDYDLDVIVKFAEEINHLYEKRKELYNYLEKLMNEEAPNITKLAGVSLGARLIGLAGGLEKLAKMPASTIQVLGAEKALFAHLRMGVEPPKHGIIYNHPLIQGSPHWQRGKIARALACKLAIAARADYVGDYIADELLEKLNKRVEEIRRKYPKPPKKKKKEKPKAKKKEKKGKKEKSKKKKDKKKDKKGKKERKVIGKTKSRK
Protein: Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) (Q10251)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P39730}.
Interaction partners:
- Probable eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 1A
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit B
- Small ribosomal subunit protein uS3
- ATP-dependent RNA helicase eIF4A
- Small ribosomal subunit protein uS5
- Probable eukaryotic translation initiation factor 3 subunit J
- Large ribosomal subunit protein eL8
- Small ribosomal subunit protein uS10
Sequence:
MGKKGKKSGYADWEDDLGEDISGQNEYLDNTSQDSPQNDELAEKSENLAVSSEKTTSKKKKGKKNKGNKNQVSDDESQELESPQGPKELTAVTELDDDEFDYKPKKGKKGKKSKKVEEDDEPQEIESPQGPKELTAVTELDDDEFDYKPKKGKKGKKAQNNNESEAAAPPEIPEVRVKTKKEKEREKKEREKLRKKQQQAKKKGSTGEDTLASSEVSSEVDISTPAENDSSAKGKQAAGSKRKGPNVTALQKMLEEKRAREEEEQRIREEEARIAEEEKRLAEVEEARKEEARLKKKEKERKKKEEMKAQGKYLSKKQKEQQALAQRRLQQMLESGVRVAGLSNGEKKQKPVYTNKKKSNRSGTSSISSSGILESSPATSISVDEPQKDSKDDSEKVEKETEVERKEENEAEAEAVFDDWEAALEEPEVAENNEVVTEKKETDIKSDAVEHSIKDKEDSKTDKVDDIPQAAPAESNVSESDLRSPICCILGHVDTGKTKLLDNLRRSNVQEGEAGGITQQIGATYFPIESIKQKTKVVNKKGKLQYNIPGLLIIDTPGHESFTNLRSRGTSLCNIAILVIDIMHGLEPQTIESIRLLRDQKTPFVVALNKVDRLYGWHSIKDNAIQDSLSKQKKAIQREFRDRVESIILQLNEQGLNAALYFENKNLGRYVSLVPTSAQSGEGVPDLVALLISLTQTRMSDRIKYITTLECTVLEVKVIEGLGATIDVILSNGVLHEGDRIVLCGMGGPIITTVRALLTPQPLKEMRVKSAYVHHKEIKAAMGVKICANDLEKAVAGSRLLVVGPDDDEEDLAEEIMEDLENLLGRIDTSGIGVSVQASTLGSLEALLEFLKQMKIPVASVNIGPVYKKDVMRCATMLEKAKEYALMLCFDVKVDRDAEDLAEQLGVKIFSANVIYHLFDAFTAHQKKILEQKREESSDVAVFPCVLKTVAAFNKRDPIILGVDVVEGVLRINTPIVAVKQLPNGEPQIIELGRVASLEMNHKPVDKVKKGQAGAGVAMKLESSGSQILFGRQVTESDALYSHITRQSIDSLKDPAFRDEVSRDEWQLIIQLKKLFGII
Protein: Ret finger protein-like 4A (Q8VH31)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12525704}. Nucleus {ECO:0000269|PubMed:12525704}.
Interaction partners:
Sequence:
MAHLFKEKSNCYFCFRCLESPVYLNCGYICCLKCLDSLEKSPEGDGVLCPTCSVVSLKEDIIHAKQLGALVTKIKNLEPQLNFILTMDQGMKIFQVTMTLDVDTAQNHLIISDDLLSVYYTPQKQARKKCAERFHPSPCVLGSSRFTSGRHYWEVVVGTSKEWDIGICKESINRKKAIHLSEKNGFWTVGVRAKKVYSASTDPLTVLRVNPRLRRVGIFLDMLEKSVSFWDLSDGSHIYTFLEIPDTDPFRPFFSPASSYPDGDQEQVLSICPVTNPGIFGIPVNPQ
Protein: Geminin (Q5ZKE6)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNSKMKQSLNVENPSGSLQKYLTDTACSAAPRRTLKMIQPSAKGFLVGRCNEKKSSVKRKLWNNRLTSSACKAEASVDKEQENENTDDVIQAIDLIKKSPSSQYWKEVAEERRKALYEVLQENEKLHKEIEQKDGEIARLKEENEELMSLAEHVHYLTSMIERLTGQESDNLEALESLALDESNQET
Protein: Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) (Q9P885)
Organism: Mucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
Function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MLNSHNRTEERSTEDIILEPYTYLISQPGKDIRAKLISAFDLWLHVPKDVLCVINKIIGMLHNASLMIDDVQDDSDLRRGVPVAHHIYGVPQTINTANYVIFLALQEVMKLNIPSMMQVCTEELINLHRGQGIELYWRDSLTCPTEEEYIDMVNNKTSGLLRLAVRLMQAASESDIDYTPLVNIIGIHFQVRDDYMNLQSTSYTNNKGFCEDLTEGKFSFPIIHAIRKDPSNRQLLNIISQKPTSIEVKKYALEVIRKAGSFEYVREFLRQKEAESLKEIKRLGGNPLLEKYIETIRVEATND
Protein: Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1) (Q8NBM4)
Organism: Homo sapiens (Human)
Function: Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23297223}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- FAS-associated factor 2
- Ubiquitin recognition factor in ER-associated degradation protein 1
- Nuclear protein localization protein 4 homolog
- E3 ubiquitin-protein ligase AMFR
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 2
- Erlin-1
- Erlin-2
- Transitional endoplasmic reticulum ATPase
Sequence:
MFTSTGSSGLYKAPLSKSLLLVPSALSLLLALLLPHCQKLFVYDLHAVKNDFQIWRLICGRIICLDLKDTFCSSLLIYNFRIFERRYGSRKFASFLLGSWVLSALFDFLLIEAMQYFFGITAASNLPSGFLAPVFALFVPFYCSIPRVQVAQILGPLSITNKTLIYILGLQLFTSGSYIWIVAISGLMSGLCYDSKMFQVHQVLCIPSWMAKFFSWTLEPIFSSSEPTSEARIGMGATLDIQRQQRMELLDRQLMFSQFAQGRRQRQQQGGMINWNRLFPPLRQRQNVNYQGGRQSEPAAPPLEVSEEQVARLMEMGFSRGDALEALRASNNDLNVATNFLLQH
Protein: V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) (P38606)
Organism: Homo sapiens (Human)
Function: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29668857, ECO:0000269|PubMed:33208464}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P50516}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:23035048}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P31404}; Peripheral membrane protein {ECO:0000305}. Lysosome {ECO:0000250|UniProtKB:P50516}. Note=Co-localizes with WFS1 in the secretory granules in neuroblastoma cell lines. {ECO:0000269|PubMed:23035048}.
Interaction partners:
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase 116 kDa subunit a 4
- V-type proton ATPase subunit B, kidney isoform
- V-type proton ATPase subunit F
- V-type proton ATPase subunit E 1
- V-type proton ATPase subunit B, brain isoform
- V-type proton ATPase subunit H
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit d 1
- V-type proton ATPase 16 kDa proteolipid subunit c
Sequence:
MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWDFTPCKNLRVGSHITGGDIYGIVSENSLIKHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEGVKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKDPLKDGEAKIKSDYAQLLEDMQNAFRSLED
Protein: Neuropeptide W (Preproprotein L8) (hPPL8) [Cleaved into: Neuropeptide W-23 (NPW23) (hL8); Neuropeptide W-30 (NPW30) (hL8C)] (Q8N729)
Organism: Homo sapiens (Human)
Function: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.
Subcellular location: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}.
Interaction partners:
- Neuropeptides B/W receptor type 1
- Neuropeptide B
- Neuropeptides B/W receptor type 2
- Pro-MCH
- Neuromedin-S
Sequence:
MAWRPGERGAPASRPRLALLLLLLLLPLPSGAWYKHVASPRYHTVGRAAGLLMGLRRSPYLWRRALRAAAGPLARDTLSPEPAAREAPLLLPSWVQELWETRRRSSQAGIPVRAPRSPRAPEPALEPESLDFSGAGQRLRRDVSRPAVDPAANRLGLPCLAPGPF
Protein: 16S rRNA aminocarboxypropyltransferase (EC 2.5.1.157) (20S S rRNA accumulation protein 3 homolog) (SsTsr3) (Q9UWV6)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01116}.
Interaction partners:
- non-specific serine/threonine protein kinase
- [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase
- RNase L inhibitor
- Translation initiation factor 6
Sequence:
MKVYIIDYHKDDPKRCTGKKLVKLKIAEFTRVGKGVVLDPFAQITLSNKDKDIVRRIGITIVDTSWNNTSQSEFKNIRGEHRRIPILFAGNPIHYGIAYKLSSIEALIATLYIVDEVEEAIKLSNVVKWGHTFIELNKELLEAYKNKTEEDIKKIEREIIEKILEK