wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphopantothenate--cysteine ligase CAB2 (EC 6.3.2.5) (Coenzyme A biosynthesis protein 2) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) (P40506)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Phosphopantetheine adenylyltransferase
- Dephospho-CoA kinase CAB5
- Coenzyme A biosynthesis protein 3
- Pantothenate kinase CAB1
- Phosphopantothenoylcysteine decarboxylase subunit VHS3
- Phosphopantothenoylcysteine decarboxylase subunit SIS2
- Pantoate--beta-alanine ligase
- Putative cystathionine beta-lyase
- Putative mitochondrial cysteine synthase
- Homocysteine/cysteine synthase
Sequence:
MPPLPVLNRPQIHTSVTEISHAIDRTIKEELFPVAYTTEEEQYFKTNPKPAYIDELIKDAKEFIDLQYSLKRNKIVLITSGGTTVPLENNTVRFIDNFSAGTRGASSAEQFLANGYSVIFLHREFSLTPYNRSFSHSINTLFLDYIDSEGKIKPEFAENVLKNKKLYDKYMEKEEKLLLLPFTTVNQYLWSLKSIAKLLNNSGCLFYLAAAVSDFFVPYSRLPQHKIQSGDNGKMGANNDTEGTTRTTPDGKLIVNLDPVPKFLRRLVESWATQAMIVSFKLETDESMLLYKCTQALDRYNHQLVIGNLLQTRNKQVIFVSPENRKGDWVRLDEKHHSIEEMIIPEVIARHDKWVAHSKTKLATK
Protein: Protein dispatched (Q9VNJ5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Segment polarity protein which functions in hedgehog (Hh) signaling. Regulates the trafficking and the release of cholesterol-modified hedgehog protein from cells of the posterior compartment (P cells) and is hence required for the effective production of the Hh signal.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein hedgehog
- Dally-like, isoform A
- Protein patched
- Interference hedgehog
- Protein smoothened
- Kinesin-like protein costa
- Protein shifted
- Suppressor of fused homolog
Sequence:
MLCFDSERMNWYYHVLARRPYLVVVSIAVYCVACIIVALVLNKLPDFSDPTLGFETRGTKIGERLTAWYNLLQETDHHGALFSNPSDLWERRRVEQGYVETKLHPNHRRRKNKHKNRNKNKRRKEQNQSSHEHHDVAQKMMQFKKRLKATSSPSPNLGFDTWIGDSGVFRDYEITNDSASSSLEPTRRTEQIEYGHNTTSVDEEEHQQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYSHFVVQRIGPNATDSLFDLNGLLAMCQLQDQITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSLHTLLLGCYEYFHDLKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVYLKYAMIFIPVAQSNRLLPLFHEWEDVELINELVEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIHACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQLPEKSHFQLFVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDYTNPNSYGHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAPRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWPLWSKRSSGSSKFYERKPSQVIASEQLLTPTSSAIVELANSETHELESLNSNSLIKTISGIESAHALSSLPRDFEHSFQTMHECKYQTYPSTSN
Protein: Transient receptor potential cation channel subfamily M member-like 2 (nvTRPM2) (A7T1N0)
Organism: Nematostella vectensis (Starlet sea anemone)
Function: Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species.
Subcellular location: Cell membrane {ECO:0000305|PubMed:27333281, ECO:0000305|PubMed:28775320}; Multi-pass membrane protein {ECO:0000269|PubMed:29745897}.
Interaction partners:
Sequence:
MGKDSFTPLYDGGDSSHVHLNKFGSNQLSQSKKSWIARNFSRRECIRFVPKSHDVSRCKCGRPRERHSQQALESGQGSEEWNVASCTTKHPTNAYGEIDFEGYGGQKRAPYLRMSHDTDANLVITLMLKRWNLEIPNLVISVTGGAKSFVLKPRLREMFRRGLIKAAKTTGAWIITGGTNTGVMKHVGEAVKEQQLMFGSDTQVNVIGIATWGIVDKQSDLISEKNGKYPALYSMEPTPGHQGAMLDPNHSHFFLVDDGTEGKYGVEIGMRSRIEEAIMKVKTDSRSEAGSIGVPVVLLVLEGGPNTVATMYELIKKKVPAVVIDGSGRAASVVGFAYNHTIKRNVDGQTINVIDPQYEDEVRAKVVEVFGAKGADKTYSMIKDVLEDEKMISVYSLDGEISQDIDLAILKALLKANRSSPVAQLNLALAWNRIDLAKSDIFTEEQQWTTETLSAAMLTALLDDKAEFAELFLQNGLSMREFLSLDILCKLYAEVPGNTTIKPLLQKEMGKRQVKTIDMDVVGEVIEELMGDMFESYYRKDGHYFGELASYAEGLVLKNRKSSKDLLANINRIDPLPTPYLDVFLWAVLCNRRELARVLWEAGREPMAAALMASRLLKRMASRAQEDNTITDISSDLYDHARLFEERAVGVLDECFNENETLSQTLLVRELDHYSRMTALELAVSAESQDFIAHTSCQVLLTRLWMGTMAMNTRWWKVLVCLYLPVLIFPIIYFVPDEQHERQAAEREHQKSLNQKSSKVKSHKEKNDAPVVPVYRSKEEKAVSNDEEARVGTENEEEDFQLEDYIPEIREDDSMEVIMRNKKLGFCDRIMHFYSAPFSKFVGNVVGYLAFIFLYAYVVLFNFPRFDPAKTLGGIHPTEIVLYFWVFTILIEEIRQLAAKPPKYIKDKVSVYFSDTWNFVDIFSLTVFIIAIILRFFTNSRIFTASRIILSLDIIFFIVRSLQIFSVNRLLGPKLVMIQKMMQDLAQFIIILAVFTIAYGIALHAVMFPSPGIYARNNTWVTITSVVQYPYWQMYGELFLDEIQGEKPKEFGEVDPDGRWLSPLLLAIYMVFTNILLLNLLIAIFNYTFERVQEDSDKVWKFQRYDLVQEYHSRPVFAPPLVLLGHILIFIRWVWRMCRCGHPPRGSTMKIGLSPAEMEQMDNWEFQAAEMYIHQQQQKNSGTLEERVRALGDRVDCINSQLNRVLDSMSGTRAHALTDGNGLEGGHDSEGRLARMEVELSSNSESLQKILALLQQQPPVKGQAAVPIQLTLLHYKARSSPYPGSTAKRFAVQDNMVDWQVPFPDYKPVNYTAPVVLANPVWADKDLMAMSPRPELPYNQMDHTCNVNRVSYNGTYVVKDGLPLNPMGRTGMQGRGLLGRFGPNHAADPVVTRWKRTSAGVMLQGGKKVLEFVAIQRKDNNQWAIPGGMVEPGQLVTQALKAEFGEEAMAKLNVSQEEKERIAKQIERLFQQGQEIYKGYVDDPRNTDNAWMETVAVNFHDDKGDLFGDITLQAGDDAAAVRWQRVSGNIPLYASHVSILEKVAKMRDAAF
Protein: Hydrazine synthase subunit gamma (HZS-gamma) (EC 1.7.2.7) (Q1Q0T3)
Organism: Kuenenia stuttgartiensis
Function: Component of the hydrazine synthase complex that catalyzes the condensation of nitric oxide (NO) with ammonium to form hydrazine. The gamma subunit catalyzes the first half-reaction, i.e. the three-electron reduction of nitric oxide to hydroxylamine; it may obtain electrons from the triheme cytochrome c kuste2854. Is involved in anaerobic ammonium oxidation (anammox), a biological process in which nitrite is used as the electron acceptor in the conversion of ammonium to dinitrogen gas (N2) and water; this bacterial process has a major role in the Earth's nitrogen cycle and has been estimated to synthesize up to 50% of the dinitrogen gas emitted into our atmosphere from the oceans.
Subcellular location: Anammoxosome {ECO:0000305|PubMed:21964329}.
Interaction partners:
Sequence:
MAREMRLGGKERMKTGVVKIGLVAALGVVGLISAGGVYAGQPRVISTIQTGATWEPLGREEPLTVPEVHFRVKHSPFKSELVRYGQFQFNDAAWSLQGSYSCASCHYERGQTTGLIWDLGDEGWGSWKNTKYIRGGRYLPPFRHEGFTGHPDEIVGATSSLDRVCGRDPGFVFRSENFSPMRLEALICYIRALEFTGSPFRNADGSLTEAQKRGQKIFEDPKVGCLECHPGDPMDPRALFSDAQTHDVGTGRVGVNGFRSTPGKVFNISALEAGEDPYGVESNTPIIGLDLVKEFDTPTLRDIYASGTYFHDGGARTLMDTINNTVNDKDMHGRTSHLKQQELQDLVEYLKAL
Protein: ESAT-6-like protein (A0A0H3L7S1)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MASRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGWSGMAEATSLDTMAQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS
Protein: SPT3, SAGA and STAGA complex component (B0QZW4)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
PMSTTTSSSGRNAGKTISFAAELQSMMFSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIIKGIDEDDLLEEKLSGSSGTNKRQKIAQDLINSIDQTGELLAMFEDNELDDVKQERMERAERQTRTMDSAQYAEFCESRQLSFSKKASKFRDWLDCSSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVSKAGDPFSHAISATFIQYHNSAEGSSCLKSSPDSPENTPPPTPTAPSSGSQHSGRAASGSLGNGNTGQDTAKTKQRKRKKSTAACGVEAHSDAIQPCHIREAIRRYGHKIGPLSPFTISLSLTECLPKEWDGFPGLLRGPWPCLPPRRGSGSPRSFLPVLPENKIGFYV
Protein: acyl-homoserine-lactone synthase (EC 2.3.1.184) (G3FB25)
Organism: Aliivibrio fischeri (Vibrio fischeri)
Interaction partners:
Sequence:
YFHIEQMAIKVFGCLLKCSTEFEMFKLIHKPMSVLHRHLDITKKNSTSAIIDEKYHYELVQDISTDERYFHTEFSEHPLPLSDAIVLINIATFIKEHKWYEMLNHLEISSKGEHFILYQYTDNNIYPTIISSALIQTTSNKHDWLFFDNFFQNTKWKPNLNADGLLSLSHATSMSPLARSQFVDKSSTEIENDLFYSILDKTKACEAIRLTISGEKSKANYHLYLAQKGLAMALKESGRDIVFTIIEKPAMVLFYQSMNL
Protein: Actin-3 (EC 3.6.4.-) (Actin-3-sub 1) (P07829)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Arginyl-tRNA--protein transferase 1
- Actin-related protein 2/3 complex subunit 1
Sequence:
MESEDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRYTGVMVGMGQKDSYIGDEAQSRKGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYSLPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFEAELQTAASSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYSNVVLSGGSTMFPGIADRMNKELTALAPSTMKIKIIAPPERKYSVWIGGSILASLPTFQQMWISKEEYDESGPSIVHRKCF
Protein: Inhibitor of growth protein 5 (Q9D8Y8)
Organism: Mus musculus (Mouse)
Function: Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8WYH8}. Chromosome {ECO:0000250|UniProtKB:Q8WYH8}. Note=Localizes to transcription start sites. {ECO:0000250|UniProtKB:Q8WYH8}.
Interaction partners:
- Chromatin modification-related protein MEAF6
- Histone acetyltransferase KAT6B
- Peregrin
- Histone acetyltransferase KAT7
- Histone acetyltransferase KAT6A
- Histone H3.2
- Histone H3.1
- Protein Jade-1
- Histone H3.3
- Cellular tumor antigen p53
Sequence:
MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEDKKAEIDILAAEYISTVKTLSSAQRVEHLQKIQSAYSKCKEYSDDKVQLAMQTYEMVDKHIRRLDADLARFEADLKDRMDGSDFESTGARSLKKGRSQKEKRSSRGRGRRTSEEDTPKKKKHKSGSEFTDSILSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCPIEWFHFACVDLTTKPKGKWFCPRCVQEKRKKK
Protein: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2 (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase 2) (PGP synthase 2) (Q9M2W3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
Subcellular location: Microsome membrane {ECO:0000305|PubMed:11741606}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24632290}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Phosphatidylglycerophosphate phosphatase 1, chloroplastic/mitochondrial
- Probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1
- Phosphatidate cytidylyltransferase 5, chloroplastic
- Phosphatidate cytidylyltransferase 4, chloroplastic
- Phosphatidate cytidylyltransferase 1
- Phosphatidate cytidylyltransferase 2
- Phosphatidate cytidylyltransferase 3
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Phosphatidylserine decarboxylase proenzyme 2
Sequence:
MGEEDTATVDQNSFGGGKDSLLRNRHSSPLPSPTQLSSKVITLPTVLTLGRVAAVPILVATFYVDCWWGRTATTSIFIAAAITDWLDGYIARKMRLGSEFGAFLDPVADKLMVAATLILLCTKPMVAVVLGPVPWLVTVPSIAIIGREITMSAVREWAASQNGKLSEAVAVNSLGKWKTATQMIALTILLASRDSSFERLLPSGIGLLYVSAGLSIWSLVVYMRKIWRVLLKK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9DG88)
Organism: Morone saxatilis (Striped bass) (Perca saxatilis)
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MRSLLKMFPQSGKSIVFDNFPDPTDTWEIIETIGKGTYGKVYKVLDKLDGSKAAVKILDPIHDIDEEIEAEYNILKALSDHANAVKFYGMYYKKDVKCGDQLWLVLELCNGGSVTDLAKGMLKRGDRMDEAIIAYILHEALMGLQHLHINKTIHRDVKGNNILLTTHAGVKLVDFGVSAQLTNTRLRRNTSVGTPFWMAPEVIACEQQLDSTYDARCDVWSLGITAIELGDGDPPLSDLHPMRALFKIPRNPPPTLHQPELWSDDFNDFICKCLIKDFELRPNVLDLLQHVFIKQIVGREKILQKQLIELIDLNQQIGVSEKTSHHGKTDRSTDSNDSSRHERIHTKRGGHMKTQTDPDEVDDLATLEVLDENTVAEKLQIRYGRDQIYTYVGDILIAVNPFHKMDIYTSQYTKMYIGAKRTANPPHIFAVADVAYQSMVSYNTDQCIVISGESGAGKTESAHLLVQQLTVLGKANNRTLQEKILLVNNLVEAFGNACTVINDNSSRFGKYLEMKFTCGGTVVGAQISEYLLEKSRVIHQAVGERNFHIFYYIYAGLADRKKLAHYKLSDSKTPKYLCNEHIKLGPDIVSNTFYKEQFDAVEQCFKVIGFTLEELGSVYSTLAAILNSGDIEFSPVATEHQTDKSDITNISVLDNVASLLCIRSDELQEALTSHCVVARGETIVRPNTVEKAAEVRDAMGKALYGRLFSWIVNRINALLRPDSIGEDDKGLNIGILDIFGFENFKKNSFEQLCINIANEQIQFYFNQHIFAWEQDEYLNEEVDARMIEYEDNRPLLDLFLQKPMGMLSLLDEESRFPQATDQTLVEKFEDNLKTKSFWRPKRVDLGFGIHHYAGKVIYNAAGFLAKNRDMLPADIVLLLRSSENELTRKLVTHPLTKTGNLAHTKGKGINTMRSPRTPTRTITFAKMGVLTLYSSFSFSEPGEPGDTPYHPRETTNMRTQTVASYFRYSLMDLLSKMVAGQPHFVRCIKPNNDRQSNKFDREKVLVQLRYTGVLETAKIRRQGYSHRILFANFIKRYYILAFHAHEEPAATQETCAAIMEKAKLENWAMGKTKVFLKYYHVEHLNLMVQQATQRIILLQAYVRGWLGAKRYQRTLKEREQSALVLQSAYRGQKVRKRVADEKSKAKLEAFITQFQAVCRGYLAKKKYNALVDEKNKAATKIQARYRGHKERKSFKRKRDAKEKEKEEKALKEKEEETTEPDTNAPAPDNETKNDEEETKAAVVLQSNYRGFKERKKFKERKKTMAGAELELPPNAVEEQEGGQDPTGSKAEEGEQTADKQEENEEDEESTYEAEENDDSDHTQVPDDEHTEVADEAVIEDIPAADAGKEGQEANKKEEIGQEKAAGEEVVKVEEETKAATVLQSNFRGHKERKRLQEEGKIPAKKQKAKTGEEEVPTVSSPTAAEEITKKEESTEAQDVADVSSVDIQLEDQDETKAAVVLQSNFRGHKERKRLEEEGKIPKKRKKKKEVTPEPPIEEEQVMQTEESVPESQSGPSAENPEGLDEEKAATVLQSNFRGHRDRKKLKAERETQQKTKEEVAKDAEEETKEEAEEEVVDVTDVVIEHKEETDAEKERLEEEQAAVKIQSNFRGYKDRKNLKANKQTAQSEAAQLESFSKEITKTSQDFLALQQKLNEIIQAHQSNPEKNGMFVRGKAINGIVPPNQQSTDKRLSRTPRRTQQPKTLNTPEDSTYYNLIHRSVQDDKRKPRKEDPGKLLDVDDQYYRSLPTSRSEPCISTEDTSLSDTPEMRQPAELRPDAASRPTRERAVTDPEPLKPASDNRRSVPRMPSAESHTDDNPYDFRHLLRKTSQRRKLIKQY
Protein: Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (Q5RGG3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Hepatocyte growth factor receptor
- Epidermal growth factor receptor precursor.
- Epidermal growth factor.
- Vascular endothelial growth factor receptor 2
- Tyrosine-protein kinase receptor.
- Mast/stem cell growth factor receptor kita
- Vascular endothelial growth factor receptor kdr-like
- Tyrosine-protein kinase receptor.
- Receptor protein-tyrosine kinase.
- receptor protein-tyrosine kinase
Sequence:
MRSDIMWMYQALLFVVLTVNVDCRKQTLQRYQKSENSRLLCTDCPESPRIRNLSLEECARKCSKSKKSCRAFYFDHINRKCHFLPFDRFSEGAKRERKPSCDLYEKKDYVRECIIGSGVNYKGRRSFTKTGITCQSWNMSVPHEHNFKPTRHKKSDLRQNFCRNPDNDPNGPWCFTELTETRHQDCGLPQCSDVECMKCNGETYRGPMDHTESGKECQRWDSQKPHKHTYQPHRHVGKGLDDNFCRNPNNDVRPWCYTMDKNTPWEYCNISVCDSDSDVEVEVTSSCFRGQGEGYRGTVNVTPAGVTCQRWDALSPHIHSYTPHNYKCKDLRENYCRNPDGSEIPWCFTTDAKVRKAFCTNIPRCESESSDSTECYEDNGESYRGNLSKTRSGIPCGLWSDHTFRRDTRSAKASAGLELNLCRNPDRDKHGPWCYTSNSSIPWDYCGLERCGGPKPSCFIHKTTRIVGGMRVQRAEDGSWVVSIQKGNRHWCGGSLIREEWVLTDQQCFSTCVPDLSEYTVQVGLLHLNASAGTQALRIAHVVCGPEGSNLALLKLTTPAPLSEHVRTVQLPVAGCAVAEGTLCLMYGWGDTKGHEGSLKMVGLPIVSNKRCSQSHNGILPITETKICAGGKRDQGVCEKDYGGPLVCQEGESKVIVGVSINGRGCAVARRPAVFVNVAFYSEWIRKVFKYYSDMEISY
Protein: MADS-box protein SVP (Protein SHORT VEGETATIVE PHASE) (Q9FVC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription repressor that inhibit floral transition in the autonomous flowering pathway, independent of photoperiod and temperature. Acts in a dosage-dependent manner. Together with AGL24 and AP1, controls the identity of the floral meristem and regulates expression of class B, C and E genes. Promotes EFM expression to suppress flowering.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:19656343}.
Interaction partners:
- Protein LEAFY
- Protein TERMINAL FLOWER 1
- Protein GIGANTEA
- Protein EARLY FLOWERING 3
- Inactive protein FRIGIDA
- MADS-box protein
- WD-40 repeat-containing protein MSI4
- B3 domain-containing transcription factor VRN1
- Protein TWIN SISTER of FT
- Adagio protein 3
Sequence:
MAREKIQIRKIDNATARQVTFSKRRRGLFKKAEELSVLCDADVALIIFSSTGKLFEFCSSSMKEVLERHNLQSKNLEKLDQPSLELQLVENSDHARMSKEIADKSHRLRQMRGEELQGLDIEELQQLEKALETGLTRVIETKSDKIMSEISELQKKGMQLMDENKRLRQQGTQLTEENERLGMQICNNVHAHGGAESENAAVYEEGQSSESITNAGNSTGAPVDSESSDTSLRLGLPYGG
Protein: Activator of SKN7 protein 10 (Regulator of the glycerol channel 2) (P48361)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Positive regulator of FPS1 glycerol channel required for the glycerol efflux. As a component of the RNA polymerase II holoenzyme, is required for SSN8 destruction in response to oxidative stress but not heat shock. Required for cell survival in response to heat shock independent of SSN8.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:19956799}. Note=Displays diffuse cytoplasmic localization, but very rapidly aggregates into punctate spots that appear near the cell surface in response to hypo-osmotic shock.
Interaction partners:
- Glycerol uptake/efflux facilitator protein
- Mitogen-activated protein kinase HOG1
- Regulator of the glycerol channel 1
- Large ribosomal subunit protein uL15m
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL22m
Sequence:
MSDYFSSRPSQTLTPMGNKPSGGGGGDDASSIHSKSSQYLMDILPDSMTLNESVSSIVANNQAKEFILPETDERSPYFINVPIPKAQPTSTTETKKPLAGDEAIDGQFVKEYPTDILVDRFYKWKKILKGLVIYLREVAYAQEQFARINYQLKGSVKFPFLTDIDETTNTITDPFTTAPRGPKKAQPAQKKVGLTDSEQFQMQMQQEQQENAVQAPTDESKMSLAPHEYKPVQTTESDNTSAASGFVKFGSGSIQDIQVILKKYHLSLANQQFKISKEITSTVIPKLEELRKDLRYKITEIKDLHGDFKTNIGAHIQLTSQLLKKYIAAVKFMNAHGIGNDRASPTNKKPHKLDPKHDPYLLKLQLDLQLKRQVAEETYLQEAFINLQSSGLQLEKIIYTKIQHALLRYSALIDSEARLMIKNMCQELQHGIISKPPAFEWDNFVTQHPSCLLNWKSNDPIPPPRKVSDVIYPHMKSPLAKCIKAGYFLKKSELLPTYHQGYFVLTSNYIHEFQSSDFYNLSSSTPNSTKSSAYSSSVSIADTYANANNAKANNHHRQASDVHNSSTTTGGTAGANGIRGIRKKSYLAPIMSIPLNDCTLKDASSTKFVLVGKPTLNENADVRKSSSSTYLSGSSQASLPKYGHETAKIFSKAPFHKFLKGSKPKNKNTKSSELDQFYAAAQKESNNYVTWTFKIVSPEPSEEELKHFKRWVQDLKNLTSFNDTKDRIKFIEDRVMKSHRFKAGHMSRNSVNIGSHTPCLTDSTFTLQDGTTTSVNLKGRAEKPQYIHIQNNSLADFDGNGFRSKVNTPAIDDYGNLITVERRPAQSPHQYSDYMATSGNTTPSYSSGSRPQSMYNGYNPAVSITSNGMMLQQSTANNNTNPTTNLRHQRNISQTSSLPGFSYTSLSLPVNSPGSSNSESSSGGYFAIPLHGNNNNNNYTQRNSEGSSPCYNDDQIRQQQQPLQMQPLSRTSSSSVNVTAMRSTSAGNSITANAPVVPKVMVNNQNVKTVAADQSATAPSSPTMNSSVTTINRESPYQTLKKTNSTGNVPCLTAEKTHAHPAFYKRGNNSAQNLTTSSSTASRVHPIRKHKKNVSFSSLNSLMFSKKGANHGGNLMTNQFMSGGIQEDDGDSTNNDTIKLNQSIYS
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (D3NQB1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPGTVSMANCGANTNGSQFFICTEKTDWLDGKHVVFGHVVEGMNIVRQVEQQGTPSGKPQMVVKIVESGEIEPEKRIAAEKLAQKAVVPGAEIQEPLPQAMET
Protein: Carbohydrate sulfotransferase 3 (EC 2.8.2.17) (EC 2.8.2.21) (Chondroitin 6-O-sulfotransferase 1) (C6ST-1) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (GST-0) (Q9QZL2)
Organism: Rattus norvegicus (Rat)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan (By similarity). Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity). May play a role in the maintenance of naive T-lymphocytes in the spleen (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Carbohydrate sulfotransferase 7
Sequence:
MEKGLALPQDCRDLVHNLKIRGRYVLFLAFVVIVFIFIEKENKIISRVSDKLKQIPQFVADANSTDPALLLSENASLLSLSELDSTFSHLRSRLHNLSLQLGIAPAMEAQGQEAVAEKPSQQAGAGTRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVFFQQGGASAAGSALVYRDVLKQLLLCDLYVLEPFISPPPEDHLTQFLFRRGSSRSLCEDPVCTPFVKKVFEKYHCRNRHCGPLNVTLAAEACRRKDHMALKVVRIRQLEFLQPLAEDPRLDLRVIQLVRDPRAVLASRMVAFAGKYESWKKWLSEGQDQLSENEVQRLRGNCENIRLSAELGLRQPAWLRGRYMLVRYEDVARRPLQKAREMYRSAGIPLTPQVEDWIQKNTQAARDSSDVYSTQKNSSEQFEKWRFSIPFKLAQVVQAVCGPAMHLFGHKLAKDTASLTNRSISLLEERGTFWVT
Protein: ESX-1 secretion-associated protein EspI (P9WJC5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Required to repress ESX-1-mediated secretion under low ATP conditions. This function requires the ATP-binding motif.
Interaction partners:
- ESX-1 secretion system protein EccD1
- ESX-1 secretion-associated protein EspJ
- 6 kDa early secretory antigenic target
- ESX-1 secretion-associated protein EspE
- ESAT-6-like protein EsxB
- ESX-1 secretion-associated protein EspK
- ESX-1 secretion system protein EccCb1
- ESX-1 secretion-associated protein EspB
- ESX-1 secretion system ATPase EccB1
- PPE family immunomodulator PPE68
Sequence:
MAADYDKLFRPHEGMEAPDDMAAQPFFDPSASFPPAPASANLPKPNGQTPPPTSDDLSERFVSAPPPPPPPPPPPPPTPMPIAAGEPPSPEPAASKPPTPPMPIAGPEPAPPKPPTPPMPIAGPEPAPPKPPTPPMPIAGPAPTPTESQLAPPRPPTPQTPTGAPQQPESPAPHVPSHGPHQPRRTAPAPPWAKMPIGEPPPAPSRPSASPAEPPTRPAPQHSRRARRGHRYRTDTERNVGKVATGPSIQARLRAEEASGAQLAPGTEPSPAPLGQPRSYLAPPTRPAPTEPPPSPSPQRNSGRRAERRVHPDLAAQHAAAQPDSITAATTGGRRRKRAAPDLDATQKSLRPAAKGPKVKKVKPQKPKATKPPKVVSQRGWRHWVHALTRINLGLSPDEKYELDLHARVRRNPRGSYQIAVVGLKGGAGKTTLTAALGSTLAQVRADRILALDADPGAGNLADRVGRQSGATIADVLAEKELSHYNDIRAHTSVNAVNLEVLPAPEYSSAQRALSDADWHFIADPASRFYNLVLADCGAGFFDPLTRGVLSTVSGVVVVASVSIDGAQQASVALDWLRNNGYQDLASRACVVINHIMPGEPNVAVKDLVRHFEQQVQPGRVVVMPWDRHIAAGTEISLDLLDPIYKRKVLELAAALSDDFERAGRR
Protein: Alpha-2,8-sialyltransferase 8F (EC 2.4.99.-) (Sialyltransferase 8F) (SIAT8-F) (Sialyltransferase St8Sia VI) (ST8SiaVI) (P61647)
Organism: Homo sapiens (Human)
Function: Alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Alpha-2-HS-glycoprotein
Sequence:
MRPGGALLALLASLLLLLLLRLLWCPADAPGRARILVEESREATHGTPAALRTLRSPATAVPRATNSTYLNEKSLQLTEKCKNLQYGIESFSNKTKGYSENDYLQIITDIQSCPWKRQAEEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKLQFSKCEVA
Protein: Agamous-like MADS-box protein AGL11 (Protein SEEDSTICK) (Q38836)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor (Probable). Is required, together with TT16/AGL32 for the maternal control of endothelium formation, which is essential for female gametophyte development and fertilization, and seed formation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Developmental protein SEPALLATA 3
- F-box protein 7
- Homeobox protein BEL1 homolog
- MADS-box protein
- B3 domain-containing protein At5g18000
- Agamous-like MADS-box protein AGL80
- Protein LEAFY
- Floral homeotic protein APETALA 2
- Protein BASIC PENTACYSTEINE1
- Protein SPOROCYTELESS
Sequence:
MGRGKIEIKRIENSTNRQVTFCKRRNGLLKKAYELSVLCDAEVALIVFSTRGRLYEYANNNIRSTIERYKKACSDSTNTSTVQEINAAYYQQESAKLRQQIQTIQNSNRNLMGDSLSSLSVKELKQVENRLEKAISRIRSKKHELLLVEIENAQKREIELDNENIYLRTKVAEVERYQQHHHQMVSGSEINAIEALASRNYFAHSIMTAGSGSGNGGSYSDPDKKILHLG
Protein: Homeobox protein Crxos (Cone-rod homeobox, opposite strand protein) (Expressing gene at morula stage protein 1) (EGAM1) (Q3UL53)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:23510645}.
Interaction partners:
- Oocyte-specific homeobox protein 8
- Oocyte-specific homeobox protein 6
Sequence:
MEASPRSLTSCTLGPLDQKFSWEQLSELEAYFKVEPYPDLQDRKIMATRLKLKEEQVEAWFIQRSLEEEMRPPLARLQQSALDGTSSPSHKALCCRPPSWKYRLIPINPPESSTSCLKDSKTVLISKTELTDEQFQKLRKHFETDRCPNEETLQAFAEELKLRKDLIRSWFITQRHRMRGYRRLFMRYYRDWKTSREYSTTRSFDRQKNSKECSQNDPGLPEALEALKRLKLSSGYQSRDGMSQDF