wanglab/gogpt-training-data huggingface dataset:
Protein: Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (D3ZRN2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364059}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 13
- Retinoic acid receptor RXR-alpha
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 6
- Mediator complex subunit 12
Sequence:
MSSLLDRLHAKFNQSRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVVCVDISLESMGEKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNATPLDKILHGSVGYLTPRSGGHLMNMKYYASPSDLLHDTTASPITLHEKNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPADNKWTPSFSAVTSANSVDLPACFFLKFPQPIPVSKAFVQKLQNCTGIPLFETPPTYLPLYELITQFELSKDPDPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGQSLQGTLVSKITFQHPGRVPLILNMIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKNKSSRVPPDKPKHQTEDDFQRELFSMDVDSQNPMFDVSMTADALDTPHITPAPSQCSTPPTTYPQPVSHPQPSIQRMGRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGMPMLGGDNGESKLKGSSQADTVDFSILSVAGKALGAADLLEHHSGSQSPLLTTGELGKEKTQKRVKEGNGMGASSGSGPGSDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSNRPFTPPTSTGGSKSPGSSGRCQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYSSSGSVSSSGSKSHHSHSSSSSSLSSASTSGKMKSSKSEGSSSAKLSGSMYSSQGSSGSSQSKNSSQTGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSISKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGSSHVSGTSSSSGMKSSSGSGSSGSLSQKTPPASNSCTPSSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPIDSQMGASTNSSNHPMSSKHNMSGGEFQSKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGDSGGEGLRPQIASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNVDSESESGSSIAERSYQNSPSSDDGVRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQTSSMTNNPILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Protein: E3 ubiquitin-protein ligase RNF128 (EC 2.3.2.27) (Gene related to anergy in lymphocytes protein) (GRAIL) (RING finger protein 128) (RING-type E3 ubiquitin transferase RNF128) (Q8TEB7)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18713730, ECO:0000269|PubMed:22016387, ECO:0000269|PubMed:38702781}. Endomembrane system {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12705856, ECO:0000269|PubMed:22016387}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). {ECO:0000250}.
Interaction partners:
- Ubiquitin thioesterase OTUB1
- Ubiquitin carboxyl-terminal hydrolase 8
- Ubiquitin thioesterase OTUB2
- Ubiquitin-conjugating enzyme E2 D1
- Serine/threonine-protein kinase TBK1
Sequence:
MGPPPGAGVSCRGGCGFSRLLAWCFLLALSPQAPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSVAVDVIPHVDNPTFEEDETPNQETAVREIKS
Protein: Interferon alpha/beta receptor 1b (Intracellular type I interferon receptor) (iIFNAR1) (K7NAJ3)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (By similarity). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (By similarity). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (By similarity). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P17181}; Single-pass membrane protein {ECO:0000250|UniProtKB:P17181}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24244163}. Note=Mainly detected in perinuclear regions, when overexpressed in RTG-2 cell line. {ECO:0000269|PubMed:24244163}.
Interaction partners:
Sequence:
MLAELPQPQNLTLLTLNTQYVLTWDWDQTTTGNSVSFTVEYMAKYKMKMKKKNWSRVCERTTRTRCDLTGSDLHYLGMYVLRVRASADGVDSDWVNKDFCPDIDASLGPPSRAELAPVGNLLDVTISDPLTSTQHSMKEHVLFLYYRILYWSRSDDPQGLKPKVLDSSNNLVTPPELEAWAWYCVMIQSRYDYYNKTSSYTEPQCMQTEGDTPYGQIFLYFLVSMMVCFLLVLLSSYAFFRFYRGLKNTFYPSIQLPAHIQEYLCDSSPGSDMPRLITADSEAELCCDKLTICPEVVLLEIHVPPPLTAPPSELEQDSGRHIRQDSGDSGIYSTEGGSAQQGRSGGEPIRRDQEVDSWQTLEQVKMEEMGRELADERDLDEGVVDVCV
Protein: Protein kinase superfamily protein (Q9SLM4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pleckstrin homology
- Transmembrane protein
- Pentatricopeptide repeat-containing protein At1g02060
- Ethylene-responsive transcription factor ERF015
- Octanoyltransferase LIP2p, chloroplastic
- GTPase ERA-like, chloroplastic
- Nucleolar histone methyltransferase-related protein
- Putative methylesterase 6
- Methylesterase 7
- Protein Dr1 homolog
Sequence:
MEGKSPDLESIGSGTTTKRSSVSSGSRSRTRRDFLSRFTDSAHFTEKLEDWFASTLENSASEGPVFDVPFELVELQKFDYALEGISFQQLTRMPSPVYASSSNALEAKAYLAIEDFLHATVKSLWEAFWSEALFYAVRILIARSVSRLDFSQSSNCVFILLVDSQYGGVVKVEGDVNKLDFDLNNVYECAADWIKKHSKIAVSPVDRIWNKLGNANWGDIGALQVVFATYHSIMQYFGAPRHSIEDLAADHSSRLHSRRQERQLGDTSLSENGMFRFQQSTMSPEIVEVQEESTKIEPEPSMKLEVGSVLWLEESNYQKGYQINEILTNGTLPYHIASPVDDAGKSVFLYVGSPPSQLEPAWEDMNLWYQVQRQTKILSIMKQRGLSSKYLPQLHGSGRIIHPGQCQKPSSGGRCDHPWCGTPILVTTPVGETVADLVNEGRFGPEEAIRCCHDCLSALSSSSSAGIRHGDIRPENVVYVTSGVRHPYFVLIGWGHAVLEDRDRPAMNLHFSSTYALQEGKLCAASDAESLIYMLYFCSGDFPELDSVEGALQWRETSWSKRLIQQKLGDISTVLKAFSDYVDSLCGTPYPLDYDIWLRRLKRNLSEDHGKEIESSG
Protein: Cold shock protein (D9HP82)
Organism: Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000408}.
Interaction partners:
Sequence:
MANGVVKWFNPAKGFGFIQPEDGGQDVFVHIAAVERSGLSGLNEGDQVAYELEEDRRSGKTSAGQLRVTGHGPAPAGGGAARGPRPPRSFDAPRGGGGGGFSAGTGESGTGVVKWFNTTKGFGFIQPDNGGGDVFVHISAVERAGLRGLNEGQQVGYELEQDRRSGKTSAGNLRIL
Protein: Gibberellic acid receptor (Gibberellin receptor GID1B-like) (Q0PIN1)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
- DELLA protein
- DELLA protein
- DELLA protein
- DELLA protein
- DELLA protein
- DELLA protein
- DELLA protein
- DELLA protein
- DELLA protein
- DELLA protein GAI-like
Sequence:
MAGSNEVNLNESKRVVPLNTWVLISNFKLAYNLQRRPDGTFNRDLSEFLDRRVPANINPVDGVFSFDHVDGATGLLNRVYQPSSLNEAQWGMVDLEKPLSTTEIVPVIVFFHGGSFTHSSANSAIYDTFCRRLVSLCKAVVVSVNYRRSPEHRYPCAYDDGWAALKWVKSRTWLQSGKDSNVHVYLAGDSSGGNIAHHVAVRAAEADVEVLGDILLHPMFGGQKRTESEKRLDGKYFVTLHDRDWYWRAYLPEGEDRDHPACNPFGPRGRSLEGLKFPKSLVVVAGLDLIQDWQLAYVEGLKKSGQEVNLLFLEKATIGFYFLPNNNHFYCLMEEIKNFVNPNC
Protein: Pre-mRNA-splicing factor SLU7-B (Protein DOMINANT COP1-6 SUPPRESSOR 5) (Protein SWELLMAP 2) (O23174)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:35222493}. Note=Colocalizes with PHYB in photobodies after light exposure, subnuclear light-induced structures. {ECO:0000269|PubMed:35222493}.
Interaction partners:
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7
- At1g80930/F23A5_23
- Initiation factor eIF-4 gamma, MA3
- 7-dehydrocholesterol reductase-like protein
- Pre-mRNA-processing factor 17
- Transducin/WD40 repeat-like superfamily protein
- Pre-mRNA-splicing factor 18
- Pre-mRNA-splicing factor 18
- Cell division cycle 5-like protein
Sequence:
MATASVAFKSREDHRKKLELEEARKAGLAPAEVDEDGKEINPHIPEYMSKAPWYLKSEQPSLKHQKNWKIEPEPKKIWYDRGKKIYQAEQYRKGACINCGAMTHSSKACMDRPRKIGAKYTNMNIAADEKIESFELDYDGKRDRWNGYDTSTYRHVVDRYDAKEEARKKYLKEQQLKKLEEKNNNENGDDATSDGEEDLDDLRVDEAKVDESRQMDFAKVEKRVRTTGGGSTGTVRNLRIREDTAKYLLNLDVNSAHYDPKTRSMREDPLPDADPNEKFYLGDNQYRNSGQALEFKQINIHSCEAFDKGHDMHMQAAPSQAELLYKNFKVAKEKLKTQTKDTIMEKYGNAATEGEIPMELLLGQSERQIEYDRAGRIMKGQEVIIPKSKYEEDVHANNHTSVWGSWWKDHQWGYKCCQQTIRNSYCTGSAGIEAAEASIDLMKANIARKEASKESPKKVEEKKMATWGTDIPEDLELNEEALANALKKEDLSRREEKDERKRKYNVNYTNDVTSEEMEAYRMKRVHHEDPMRNFPG
Protein: Serine/threonine-protein phosphatase PP1 isozyme 8 (EC 3.1.3.16) (Type one protein phosphatase 8) (O82734)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine-protein phosphatase that possesses phosphatase activity toward para-nitrophenyl phosphate (pNPP) in vitro.
Subcellular location: Nucleus {ECO:0000269|PubMed:19329567}. Cytoplasm {ECO:0000269|PubMed:19329567}.
Interaction partners:
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Flowering time control protein FY
- Transducin/WD40 repeat-like superfamily protein
- Protein ANTHESIS POMOTING FACTOR 1
- Cleavage and polyadenylation specificity factor subunit 2
- Plant intracellular Ras-group-related LRR protein 3
- Plant intracellular Ras-group-related LRR protein 7
- Plant intracellular Ras-group-related LRR protein 6
- Plant intracellular Ras-group-related LRR protein 4
- Plant intracellular Ras-group-related LRR protein 8
Sequence:
MMTSMEGMVEKGVLDDIIRRLLEGKGGKQVQLSESEIRQLCFNARQIFLSQPNLLDLHAPIRICGDIHGQYQDLLRLFEYGGYPPSANYLFLGDYVDRGKQSLETICLLLAYKIRYPSKIYLLRGNHEDAKINRIYGFYDECKRRFNVRLWKVFTDCFNCLPVAALIDEKILCMHGGLSPDLDNLNQIREIQRPIEIPDSGLLCDLLWSDPDQKIEGWADSDRGISCTFGADKVAEFLDKNDLDLICRGHQVVEDGYEFFAKRRLVTIFSAPNYGGEFDNAGALLSVDESLVCSFEIMKPAPASSSHPLKKDFHNRTLGYNLSA
Protein: E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) (Q69ZS0)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
Subcellular location: Synapse {ECO:0000269|PubMed:17576800}. Cytoplasm {ECO:0000250|UniProtKB:E7FDW2}. Note=Localizes to the postsynaptic region of neuromuscular junctions. {ECO:0000269|PubMed:17576800}.
Interaction partners:
Sequence:
MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARCRHAGCGQLLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPCVDNQDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPASESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPASHDYYDPNDYMGDIHQDMDREELELEEVGLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGEDATASANPLAGQRKLTCSQDTLGSGDLPFSNESFISADCTDVDYLGIPEDECERFRELLELKCQVQSASPYSLYYPSSPLDAAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWMLHHSGFRNYNTSVDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRVAEGSSEGATANIEAYRPSPKNLLAITEDPEVSTPSYNPSAKELDPSQALEIKERRGSDGSRSPTASPKLGNAYLPSYHHSPYKHAHIPAHAQHYQSYMHLIQQKSAVEYAQSQMSLVSMCKDLNSSNSVEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGLTTDDDAMSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQASDDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV
Protein: Kinesin associated protein (Q5G8B9)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Interaction partners:
- Kinesin-like protein
- Kinesin-like protein
- Intraflagellar transport protein 57
- Osm-6-like protein
- Kinesin-like protein
- Uncharacterized protein
- Kinesin-like protein
- Kinesin-like protein
- Kinesin-like protein
- Kinesin-like protein
Sequence:
MAEVKKKIKPGAIEAHAEELAIVVHYEVQEVSTQSDGSQKVISKEPGEKKISVKSLSEKTNVPLLATEIIEKCKLIHPSKAGQVEELLYQLQSRGGGGGADAKAKPAAKPAAASPAKSAAAAPPPPSNVAQSPQKPGQPPSTPSKKPPAAAGAPAPMLNGKPAPKAQSRLDAEAEERADLQARRQAQAMQIFKMQQKQYEQAYMNKLDEYIEGLYEEEMPKKVRATGMIAQLFRNTENFEVLLSHETLMQTLSRVLREDGKRSIDLCTNIISVFFSVSNFTQFHGLIMQNQVGALTMDLIDLEIKRTEHRASEENISPAMVAQKALEASQGQVTLSEREKKLLALIQKQDRLLYIAFYMLLNLSEDIEVERKMKKKNIVVYLVKMLERSNVELLILATTFLKKLSIYKENKETMSSCKIVEKLMKFVPVLNDVLLMSVLRLLHNLSFDHSLRDDMVKHGLIPKAVELMMVPRFQPVVLGLLYHISMEDKYKSLFTFTDCLNKMYDMLMRVQADLRNTPELIALAVNLTQNPRNAETMCEGDRFDKMMRRAFQTCDELMFKVLRNLSQQEGINIKRRFGPYVEQLVTLLRAPDITAELFVEVLGCLANLYIPEFDFLGLVRKHDLLTFLATYAQPGAVDDDILLEVVMFVGVLCNEGTAPLIVSSGLVTTLFQLMGDKKEDDEFVLQIAFTFHKFLLHDETRASLLTNTQQVVFYLVDLLQDKNKEVRRVADQCLDIIMDTDEEWAVQIRNLKFESFNQEWLDVVSQPAGGMAAHAGRQRNGYDDETEVDYSGGDGYYNIGDQRLVADFDDLGTNGGTWGPGDEGLQGGYEGNYDGYDEEELRQGYAM
Protein: ATPase complex subunit (Q0WRX7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- E3 ubiquitin-protein ligase UPL4
- E3 ubiquitin-protein ligase UPL3
Sequence:
MATTLNRILKHRSVSALNKHHQGLFSLTRYENHDSLPSQMPALRSTTRSFLDFYKFGNKKAIEDERARLNDEMNRGYFADMKEFKEHGGKIAAANKTIIPAASAIKFPVLAVTFSNGKSLKLPIAPNSNEVDTESLVVPKVSLVCLSFRASSQEMISSWSKPFLESFGNRKDLQLFEVSFIDKWLLGLAPIRKLLLRVLQKPNNNENSVLQRQVGYAFGDHYYFRKEIKVLNLLTGYILLLDKSGRIRWQGFGTATPEEVSQLLSCTSLLLEDQ
Protein: G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 (EC 2.7.11.1) (Calmodulin-binding receptor-like protein kinase 1) (Receptor-like protein kinase 2) (S-domain-1 (SD1) receptor kinase 13) (SD1-13) (Q9LPZ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor-like serine/threonine-protein kinase that represses the disease resistance signaling pathway triggered in response to bacterial pathogen such as Pseudomonas syringae pv. tomato.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19071125}; Single-pass type I membrane protein {ECO:0000269|PubMed:19071125}.
Interaction partners:
- Probable carboxylesterase 11
- PX domain-containing protein EREX
- Protein kinase PINOID 2
Sequence:
MGCLLILLLTLICFSLRLCLATDVITFSSEFRDSETVVSNHSTFRFGFFSPVNSTGRYAGIWFNNIPVQTVVWVANSNSPINDSSGMVSISKEGNLVVMDGRGQVHWSTNVLVPVAANTFYARLLNTGNLVLLGTTNTGDEILWESFEHPQNIYLPTMSLATDTKTGRSLKLRSWKSPFDPSPGRYSAGLIPLPFPELVVWKDDLLMWRSGPWNGQYFIGLPNMDYRINLFELTLSSDNRGSVSMSYAGNTLLYHFLLDSEGSVFQRDWNVAIQEWKTWLKVPSTKCDTYATCGQFASCRFNPGSTPPCMCIRGFKPQSYAEWNNGNWTQGCVRKAPLQCESRDNNDGSRKSDGFVRVQKMKVPHNPQRSGANEQDCPESCLKNCSCTAYSFDRGIGCLLWSGNLMDMQEFSGTGVVFYIRLADSEFKKRTNRSIVITVTLLVGAFLFAGTVVLALWKIAKHREKNRNTRLLNERMEALSSNDVGAILVNQYKLKELPLFEFQVLAVATNNFSITNKLGQGGFGAVYKGRLQEGLDIAVKRLSRTSGQGVEEFVNEVVVISKLQHRNLVRLLGFCIEGEERMLVYEFMPENCLDAYLFDPVKQRLLDWKTRFNIIDGICRGLMYLHRDSRLKIIHRDLKASNILLDENLNPKISDFGLARIFQGNEDEVSTVRVVGTYGYMAPEYAMGGLFSEKSDVFSLGVILLEIVSGRRNSSFYNDGQNPNLSAYAWKLWNTGEDIALVDPVIFEECFENEIRRCVHVGLLCVQDHANDRPSVATVIWMLSSENSNLPEPKQPAFIPRRGTSEVESSGQSDPRASINNVSLTKITGR
Protein: Heterogeneous nuclear ribonucleoprotein H1 (D6RFM3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQE
Protein: Receptor-type tyrosine-protein phosphatase (EC 3.1.3.48) (E7EZG7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MVLVLFLSVTTPQVTTNATENNHGDPGPFNTHILSILLGLSVLLLFLGLLTWYCLRLKNQRKAVITAVDKKVPNGILEEQEQQTVVLLPRSPSTSKTYLPIPVDNLEEEYRIRSADDGKLFREEYSSLPGGSIQGTCEEANKEENKEKNRYPNILPYDQSRVILTPMDGVTCSDYINASYIDGYKDKNKFIAAQGPKQDTTADFWRMIWEQKSSTIVMLTNLKERKEDKCYQYWPDQGCWTYGNVRVAVEDFTVLVDYTIRKFCVQYQASDGSKSPRLVTQLHFTSWPDFGVPFSPIGMLKFLKKVKQVNPSYAGPIVVHCSAGVGRTGTFIVIDAMIDMMHTEQKVDVFGFVSRIREQRSQLIQTDLQYSFVYQALLEYFLYGDTELDVSSLEGHLQKLHNTNAPLDRVGLEEEFKKLTNMRIMKENMRTGNLPANMKKNRVLQIIPYDFNRVILSMKRGQEFTDYVNASFIDGYRQKDYYIATQGPLVHTVDDFWRMAWEWKCHSIVMLTELQERDQDKCFQYWPSEDSVTYGEFSVEIKGDTLCETFSLRDLVLTHTPEKQTRLVRHFHFHGWPEIGIPAEGKGMIDIIAAVQKQQQQSGNHPIIVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQTVKSLRMQRPHMVQTVEQYDFCYRVVQDFVDIFSDYANFK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q5ASA0)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- non-specific serine/threonine protein kinase
- DNA replication initiation factor Cdc45
- DNA replication licensing factor MCM4
- 3'-5' exonuclease/helicase
Sequence:
MTPPSVSPIPSQVSSAATSQISSDHGERQVTQALAGMNLSALNGDAALPHSVKPPKQTMANRISRMFTGTGRSTPKEPESSRELSDSSSDGGKPTTNGSGKQSRPTSRPSSKPPSRAPSRQTSTKEVPKSEKNEKNEKTDRKAKPAGKDQKEGSTVQKRFEILPDNSHRHHLKSTRRQEKLTDLLRDMLGGRKKDDHAEDQQLSLMSTWIDQFKSERDKLAADKKGGPNATASLVDKYGKCQEIVGRGAFGIVRISHKVDPKDSKSEQLYAVKEFRRRPQETSKKYQKRLTSEFCISSSLRHPNIIHTLDLLQDAKGDYCEVMEYCAGGDLYTLVLAAGKLEVAEADCLFKQLMRGVEYMHEMGVAHRDLKPENLLLTTHGALKITDFGNGECFRMAWEKEAHMTAGLCGSAPYIAPEEYVEKEFDPRAVDIWACGVIYMAMRTGRHLWKLARKEEDEFYRRYLEGRKHEDGYAPIETLHRARCRNVVYSILDPNPSRRINSSQILKSEWLREIKLCQAGEEGF
Protein: Hattifattener, isoform B (Hattifattener, isoform D) (M9PC50)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRPGRTTTALPAATTPLLLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTLASNAFRGLEQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKSTTTISATTASPASNPPVNGTGTVQATSITTSSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYPPQRGTRIDDANEVQVKHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQGPPLESSEREFKIKNVPAQECIIVCVISLEELHVTPETVPYQQCREVRTVASQASNMDKITIAASAAICGTIIVAVIVFIAASRRSRKLQSSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLSAFNNHKEWDQVSAYSGRSIPRPRIYPVEQPDDMRSHFSGMPGKVGKSRSLADGQSQHSFSNNSHRGYLGSAFPSNLVNSRPELRQSRQSLAAASERMSRASYAGSIHGGNGGGGGLGGNGGGGGNGLPVSSLMAMSGMVGGGGPASIASSARRSRPRSRSREQLNTTHIHNHRPGSRYSQAGSTHTLNNYCDTSDNWTDHDMDIYMARNPTTRNGLVPL
Protein: Transcription initiation factor TFIID subunit 7-like (TATA box binding protein-associated factor RNA polymerase II subunit Q) (TATA box-binding protein-associated factor 50 kDa) (Transcription initiation factor TFIID 50 kDa subunit) (Q9D3R9)
Organism: Mus musculus (Mouse)
Function: Probably functions as a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis.
Subcellular location: Nucleus. Cytoplasm. Note=Cytoplasmic in spermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates into the nuclei of pachytene spermatocytes and round spermatids.
Interaction partners:
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 8
- TATA-box binding protein associated factor 4
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 2
Sequence:
MERGEEAPTEGAPPEGALVEAKAPVIPEAPATDVSTTEEAGSKEPQVPSGPRPEGAGDTCDTRGARGPPTPGRAKSQKTPRQGTARCQTLESAMRSMSVRLECHDVEEQFILRLPPEQAYAVRKIIHSRNAAWKDKLKIDFSPDGHHAVVQVDNVSLPAKLVNLPCVIGSLKTIDRKTFYKTADVSQMLVCSPEGEPHSPPEEPVVSTGPTVIGISEGKAERKKYNWKHGITPPLKNVRKKRFRKTTKKLPDVKQVDEINFSEYTQSPSVEKEVKRLLYSDAEAVSVRWEVVDDDDAKEIESQGSMPTTPGISQMGGASLSDYDVFREMMGDSGSNSNDVEEKSNEGDDDDDEDEDDEDYGNEKEEEETDNSEEELEKELQAKFNEFSLHEADQDYSSITMAIQKLIFIKEKRLQMIYKKAQRQKELLRKVENLTLKRHFQNVLGKLNIMEKEKCEQIYHLQEQLKCFLKE
Protein: Glutathione S-transferase DHAR2 (EC 2.5.1.18) (Chloride intracellular channel homolog 2) (CLIC homolog 2) (Glutathione-dependent dehydroascorbate reductase 2) (AtDHAR2) (CytDHAR) (GSH-dependent dehydroascorbate reductase 2) (EC 1.8.5.1) (Q9FRL8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Displays a dual function. As a soluble protein, exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities. Exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities. Key component of the ascorbate recycling system. Involved in the redox homeostasis, especially in scavenging of ROS under oxidative stresses. Plays a role in ozone tolerance.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Monodehydroascorbate reductase 3
- L-ascorbate peroxidase 3
- L-galactono-1,4-lactone dehydrogenase, mitochondrial
- Glutathione reductase, chloroplastic
- Glutathione synthetase, chloroplastic
- Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic
- Putative glutathione peroxidase 7, chloroplastic
- Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial
- Probable glutathione peroxidase 2
- Probable glutathione peroxidase 4
Sequence:
MALDICVKVAVGAPDVLGDCPFSQRVLLTLEEKKLPYKTHLINVSDKPQWFLDISPEGKVPVVKLDGKWVADSDVIVGLLEEKYPEPSLKTPPEFASVGSKIFGAFVTFLKSKDANDGSEKALVDELEALENHLKTHSGPFVAGEKITAVDLSLAPKLYHLEVALGHYKNWSVPESLTSVRNYAKALFSRESFENTKAKKEIVVAGWESKVNA
Protein: PHO85 cyclin-5 (G1/S-specific cyclin PCL5) (P38794)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Positively controls degradation of transcription factor GCN4 under favorable growth conditions. The PCL5-PHO85 cyclin-CDK holoenzyme phosphorylates GCN4, which is required for its degradation by the E3 ubiquitin ligase complex SCF(Cdc4). Amino acid starvation reduces PCL5-PHO85-associated GCN4 kinase activity and leads to stabilization of GCN4.
Interaction partners:
- Cyclin-dependent protein kinase PHO85
- General control transcription factor GCN4
- PHO85 cyclin-9
- PHO85 cyclin CLG1
- PHO85 cyclin-2
- PHO85 cyclin PHO80
- PHO85 cyclin-6
- Serine/threonine-protein kinase ATG1
- PHO85 cyclin-7
- PHO85 cyclin-8
Sequence:
MDGNHRFTPDSKEFNTVVKSKESSTGRNPYQTPPLEHNGTHHQTNYSRKKTNLAIIISNFLSEISRPLSNGKINNSTHNILKFLNEVLKRSKCSKENAVLATFYFQKIHQSRGVRDESSLPEFSHCSRRIFLCCLILSHKFLNDNTYSMKNWQIISGLHAKDLSLMERWCLGKLNYELAIPYDEFLLWETNTLMKAKLRVGTPANAPVKRPRESDNDYDANSWKQIKSC