wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q23144)
Organism: Caenorhabditis elegans
Interaction partners:
- LITAF domain-containing protein
Sequence:
MTWNTCSLCVTSELMNTLDEAKIPLQKAVNYHEQSQNRQFRITLITKCLENQENPEKSEVSVNFFVDLKELVPSCAYFEKFDGLSYVEFSTNCKSTWISAPESVAAPHEDCSHRFQSPIISRNFHAFLDSVCPSLYGIRPTPLTLSSIVPVLDMLSHFHSEPLLTNCERFLMSTNIGHLDGNHLIRLLDKGLCVSLDHRILGRILCICLMSPQAKMSDSSQELAGTIGSVFAQAFVANISKSFRHIKPLEQESSLWPMAMRNLLIPGALGANSSSSKGSSEEKIGNKKRKRQECDHNEESFECILCFDQRCGKCKGEAAFCYKALDNFLYEIRLQLYPHTYRPHLDRDLLREERLSDYILRNQFQPLPDAN
Protein: CDGSH iron-sulfur domain-containing protein 2 (D6RCF4)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU369084}; Single-pass membrane protein {ECO:0000256|RuleBase:RU369084}. Mitochondrion outer membrane {ECO:0000256|RuleBase:RU369084}; Single-pass membrane protein {ECO:0000256|RuleBase:RU369084}.
Interaction partners:
Sequence:
MPQGLLSSELSPVSFRGKIPGFCREGAELGTGQSLSSPVLLIALFSEWLRLLPFLGVLALLGYLAVRPFLPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKKEV
Protein: Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) (P36551)
Organism: Homo sapiens (Human)
Function: Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX and participates to the sixth step in the heme biosynthetic pathway.
Subcellular location: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q3B7D0}.
Interaction partners:
- Uroporphyrinogen decarboxylase
- Protoporphyrinogen oxidase
- Delta-aminolevulinic acid dehydratase
- Ferrochelatase, mitochondrial
- Porphobilinogen deaminase
- Uroporphyrinogen-III synthase
- Endonuclease V
- MTRF1L release factor glutamine methyltransferase
- Methyltransferase HEMK2
- 5-aminolevulinate synthase, non-specific, mitochondrial
Sequence:
MALQLGRLSSGPCWLVARGGCGGPRAWSQCGGGGLRAWSQRSAAGRVCRPPGPAGTEQSRGLGHGSTSRGGPWVGTGLAAALAGLVGLATAAFGHVQRAEMLPKTSGTRATSLGRPEEEEDELAHRCSSFMAPPVTDLGELRRRPGDMKTKMELLILETQAQVCQALAQVDGGANFSVDRWERKEGGGGISCVLQDGCVFEKAGVSISVVHGNLSEEAAKQMRSRGKVLKTKDGKLPFCAMGVSSVIHPKNPHAPTIHFNYRYFEVEEADGNKQWWFGGGCDLTPTYLNQEDAVHFHRTLKEACDQHGPDLYPKFKKWCDDYFFIAHRGERRGIGGIFFDDLDSPSKEEVFRFVQSCARAVVPSYIPLVKKHCDDSFTPQEKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPSENSKEAEILEVLRHPRDWVR
Protein: Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM domain only protein 1) (LMO-1) (T-cell translocation protein 1) (P25800)
Organism: Homo sapiens (Human)
Function: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- LIM domain-binding protein 1
- T-cell acute lymphocytic leukemia protein 1
- LIM domain-binding protein 2
- T-cell acute lymphocytic leukemia protein 2
- Protein lyl-1
- Trans-acting T-cell-specific transcription factor GATA-3
- Erythroid transcription factor
- Transcription factor E2-alpha
- T-cell leukemia homeobox protein 1
- T-cell leukemia homeobox protein 3
Sequence:
MMVLDKEDGVPMLSVQPKGKQKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGTTGNCAACSKLIPAFEMVMRARDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQMDYEEGQLNGTFESQVQ
Protein: Cilia- and flagella-associated protein 263 (Q57UP0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
Sequence:
MATEVKPAGSTLEFLVGENNEQQLWAEVYTRQFPTDDEFECLTAEEQGELLAELREEVELLDVEAGMMQRHAESLRLTRSTAPTTNVSSARRSLMAFVSGGTGNLSEEATPGDSAAVNQSDDWSEQQVAAAATGSGVLNTTSTGSTRRGQPYSRKLADAKDAYVVLEDRVAMLTKERERMKQQKDKEERDNDHLRDLFRATVEEAVNRMKELRLEELQFNREVICEATGTASADDLLRYMNNRHGAQGKYLDKLNAQCAAAERSILQHQRNLKQRRAAGEAFHAIDFEQLRIENQKFVERIERKNLELVELKGTSTRTVQTLNNLMDTLNGLTSEQSRLRKDYKNRCEYLARLKREMVSVAQEAKVAEQKNTAIKLRHEAVRVPKIENYMAQKAEEYELRKAQRNWQRKVEIAEGQLGLMKQQIRVLVNATDAQRRRKRLLAHQRSTASTKHSVHGRRTSVSGETRTANFACPDGTIDVQVQQEPVVGGSKGLLDMKRRQ
Protein: Sorting nexin-4 (Autophagy-related protein 24) (O14243)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), autophagy, mitophagy, and pexophagy.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P47057}. Preautophagosomal structure membrane {ECO:0000250|UniProtKB:P47057}; Peripheral membrane protein {ECO:0000250|UniProtKB:P47057}. Endosome membrane {ECO:0000250|UniProtKB:P47057}; Peripheral membrane protein {ECO:0000250|UniProtKB:P47057}. Note=Endosome and other perivacuolar punctate structures. Associates to phosphatidylinositol 3-phosphate, necessary for peripheral membrane localization to the perivacuolar punctate structures. {ECO:0000250|UniProtKB:P47057}.
Interaction partners:
- Sorting nexin-41
- Autophagy-related protein 20
- Taz1-interacting factor 1
- Vacuolar protein sorting-associated protein 26
- Putative pyridoxal kinase C6F6.11c
- Vacuolar protein sorting-associated protein 17
- Vacuolar protein sorting-associated protein 29
- Autophagy-related protein 8
- Vacuolar protein sorting-associated protein 35
- Serine/threonine-protein kinase atg1
Sequence:
MSDSVNLDEPSTNSTHFLQCLVTEPRKELQGSRDTHVSYLIITKTNLSIFTRAECKVRRRFSDFVKLQEILSRMNEDCVVPPLPAKHKLEYIKGGRFSDNFINRRAKLLNRYITRCALHPVLHQSPHFIAFLENPNWNNYVRFFIQPKLNNTSKLDEISDSLLNAFSKLKEEPTEFDIQRDHVQQFMFGISNLEGSIQKLLRLEKALESDYEDVSIQFDRLASLDQALDVPIESIQNALQQTGTEYANLTEKLTLLLDTIKDVESYAHSLKELLKRRDQKQQDVEALQEYSAKLSLERDKISSGGSNGFSLSKTLDDLRGIDHNDTRLKRLEHVQSELQAVEQAIQEASAVHDAFNQRVREESKLFDSVRQSEMLSAISDYANVHVEFFTNIRDLWIRVKQ
Protein: Terminal uridylyltransferase Tailor (TUTase Tailor) (EC 2.7.7.52) (Q9VI58)
Organism: Drosophila melanogaster (Fruit fly)
Function: Uridylyltransferase which mediates terminal uridylation of miRNAs, leading to their degradation. Has high specificity for splicing-derived miRNAs (mirtrons) and other miRNA substrates containing a 3'-G terminal nucleotide. Appears to be a major suppressor of mirtron biogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26145176}.
Interaction partners:
- Dis3 like 3'-5' exoribonuclease 2, isoform C
- Inactive non-canonical poly
- Non-canonical poly
Sequence:
MRIEPGDSFWTKKAMFSNAERQYFETVRPRKTSLPGSTAPNIAAPVTKATKKNKTMAEMMPNKLLYMNPLTMEAHFFLQTLNSVNQTTNPPQLDPHLANLLERIMVGIESYLDRNPTYVLPQEMAAPGEGVAFVQPQELQTIKRTFSCSSCSNRIVGTTIAKAVAHLSEQHPKPNPNNQPVQPHPTHQTKQEKKQAQVKARQHITVRLPKKARAMIVGEITNVFKDKYPIADKLKVIPEYDVIEQDLCKLLSPGFPKQPLRVYKFGSRITGIGNRSSDLDLFVDIGNTFHTFEHRASNATVAKLRAMRKFFCDSEDWRLINFIEQARVPIIKTCHLPTGIECDICLNSMGFCNTNLLKYIFESQPLTQYMCIYVKNWLERCKLTEQISTYSITLMVIYFLQLQALLPPIAMLQIEDAANQAVLVGPWVVNFAQKSFSELGLQQLKATVPVIKGFLRNFFAYFAKFDYEHFLVCPYIGQANVEIAKIERMLHARYSAYVSDNPECSIQLKKPMVVQDPIQLNHNVTKAVTKYGLQTFVDYCQQTAELLEEPSTNWRQRYAF
Protein: Carboxypeptidase inhibitor (TCI) (Q5EPH2)
Organism: Rhipicephalus bursa (Tick)
Function: Potent competitive inhibitor of metallo-carboxypeptidases CPA1, CPA2, CPB, CPN and TAF1a. Accelerates fibrinolysis in vitro and may contribute to the maintenance of host blood liquidity during feeding.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MAATLPVFAVVFFAMVLASSQANECVSKGFGCLPQSDCPQEARLSYGGCSTVCCDLSKLTGCKGKGGECNPLDRQCKELQAESASCGKGQKCCVWLH
Protein: Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (FRS2-alpha) (Suc1-associated neurotrophic factor target 1) (SNT-1) (Q8C180)
Organism: Mus musculus (Mouse)
Function: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Subcellular location: Membrane {ECO:0000269|PubMed:8780727}; Lipid-anchor {ECO:0000269|PubMed:8780727}.
Interaction partners:
- Fibroblast growth factor receptor 1
- Growth factor receptor-bound protein 2
- Tyrosine-protein phosphatase non-receptor type 11
- Adapter molecule crk
- Son of sevenless homolog 1
- GRB2-associated-binding protein 1
- Fibroblast growth factor receptor 2
- BDNF/NT-3 growth factors receptor
- Crk-like protein
- High affinity nerve growth factor receptor
Sequence:
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGVMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERSSHQTELEVPRTPRTPTTPGLGAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRASVHVPPEARVSNAESNTPKEEPSNPEDRDPQVLLKPEGVRFVLGPTPVQKQLMEKEKLEQLGKDPVSGSGAGNTEWDTGYDSDERRDVPPVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRPALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIDYSKRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM
Protein: Xaa-Pro dipeptidase (A0A0H2USB7)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MEFRTIKEDGQVQEEIKKSRFICHAKRVYSEEEARDFITAIKKEHYKATHNCSAFIIGERSEIKRTSDDGEPSGTAGVPMLGVLENHNLTNVCVVVTRYFGGIKLGAGGLIRAYAGSVALAVKEIGIIEIKEQAGIAIQMSYAQYQEYSNFLKEHGLMELDTNFTDQVDTMIYVDKEEKETIKAALVEFFNGKVTLTDQGLREVEVPVNLV
Protein: Uncharacterized protein (Q385D1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHRSGTSAGTSTRFSCSSHSCQRDRCGASWSDYCWPHGPGYSSRPSIEKSGNKRRMRSREMSSHTPPSIDKDSYAATVRRSTAFTSEAGSQCGATTDVNLPVPPFFCQVGHTAVEGELMAGDCHNGGKKLKGCPSRRTAPSPQAVAGYSTLCNPVNTVIAENLGDNSETPTKVLDPSAPTASRATANGGSWPVTPPILKGGLVTLRFASPASRKSDFTQTVDSHAEVLKRLEREHRRRCGRALYVLQQIQPDPLRPHRPSDHHDVYLRNLLAHDDNFVFSRVKGEVRDDGVQWLSV
Protein: Locomotion-related protein Hikaru genki (Q09101)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays a role in the formation of functional neural circuits from the early stages of synapse formation. Has a role in the development of CNS functions involved in locomotor activity.
Subcellular location: Secreted {ECO:0000269|PubMed:8625810, ECO:0000269|PubMed:9914413}.
Interaction partners:
- Latrophilin Cirl
- Hig-anchoring scaffold protein, isoform G
- Nicotinic acetylcholine receptor alpha7, isoform E
Sequence:
MWSRQRMRHKPLWALISLTVLLLVLDKSNANTEPVETSTTSEPDASPGCRAPDVRFTIVKPEATTEQPLAKFETTQIYLPEDFTTADVEFVDSVPRHPNENHAAVINPYSLDLGDDHLHVGDAAASLVGDDDLGDEDEDHHGDPEDKRLNANRKQGKRRRAGSGRRRRIENENGQTGRGRGSRYKRHAILHDTEASPETDRWAGSKLAAEGDVYYVHIADILKSREPNRELKSKLHKLKMKARLNKCLAEGGKEKCTRLLKKKPKKKVVEKEQTLKKEKKFPKEEQSKEKVPENGQTPKEDELELDHPETAAAHHRRRGDSHAAELDQRDRSPRWRRRRSTEFKGDLGQLPPESGIGPEPEPLADQDLKDLQQYGNQSSSARVALLWQRVKRKSGKTTGALSRPKGGGDSSSKTTSRKDKGIYDEEAGYTPIHPDDPEFDEEEEEDEEVDILQQFTEVSEIRFPGEIGPMGDRRLCKIRCVKGKWVGPLCATNEEDDNGNVKFQPLYKSCHVNRIPSHLLLSYRNISVTPIPPNRGWRKTRLSKSTLLSNTEINVGWDLPHGHSLQARCQELGIYKLLGESRVLCSNGLWAPRMPSCVPTTVLTNYSEDSAPSIRIKIFNGSHSFEPSGVMAVPPHSTVLMDCMYPRVRGTPEWSWTSWYMQYSTGWSPAQEEKAVRYRLSIKNIENNDSGTFTCTSPRGLTNSIAVVVATSTCPQLTEPLAPLKLRLEGNKLGQRAHYECPEGFRLDGAWNATCLASGNWSSPTPTCHAIQCPRLELDDPHLSLIELNTSAWGRAVFKCQWGFKLTGPAQLDCEPSGVWSGPVPRCKVIQCVMPVAPLNGRIGGTSLSQRRLTVGALVTFSCNDGHSLVGESSIICTENGQWSHSPPFCKSQCPYPGDPPNGLIAPLKFNYDAGDYLSVQCRPGFVQSYEGPPERPKCQPDGRWSGPMPKCKSYEEV
Protein: Putative uncharacterized transporter YOL162W (P0CF19)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative uncharacterized transporter YOL163W
- Uncharacterized protein YER039C-A
- Alkyl/aryl-sulfatase BDS1
- High affinity cysteine transporter
- Glutaredoxin-8
Sequence:
MGLLAYIPTNVLATYLTLVLRSIGFTTFQANLLAIPNFVLHILLLFGLTWSTEKCNNRLGLSLLQPLYTVPLLAVLRFWKGTMFNKWGTYAIITLILDNPYIHAICVSLCSRNSQSVKTRTVSTCLYNMFVQAGLIISSNIYAKSDAPLYRKGNGVLFGLALFMFPILIGSKLIYVYINKQRDKRWNAMSEEEKDHYLSTTSDAGSRRLDFRFYH
Protein: Carbonic anhydrase (EC 4.2.1.1) (Q7SZR2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MVCSVSGSVSWCYHSPSCSEVTWPIIAEKHCNGTQQSPINIVTANVKANANLTSFTYVGYNDSTALTVIKNTGTSIQVTLDPKKMRVAGGNLPGRFASTEFHLHWGNGSAMPGSEHTVNGKRFPMELHIVNKPVSNTSDSLAVLGVFIEASNETGKPESWKTLTSYLTRIVKAGDKANLFRNLSMDDLLSGVDRTKYYRYLGSLTTPNCNEGVIWTVFKDPIRVSRDLIDLFSTTVYINNSSNSPLMTNIFRSVQPVNGRIVMSQVAGTKTPGLLNPTSIAANLSSSLMYPILSLTFLYCVLAFM
Protein: Keratin, type I cytoskeletal 13 (47 kDa cytokeratin) (Cytokeratin-13) (CK-13) (Keratin-13) (K13) (P08730)
Organism: Mus musculus (Mouse)
Function: Type 1 keratin (Probable). Maintains postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially via regulation of the G1/S phase cyclins CCNE1 and CCNE2.
Interaction partners:
- Keratin, type II cytoskeletal 4
- Small proline-rich protein 3
Sequence:
MSCRFQSSSMSYGGGFGAGSCQLGGGRNISSCSSRFVTGGSAGGYGGGMSCGFGGGAGGGFGGGFGGGFGGSYGGGFGGGFGDFGGVDGGLLSGNEKITMQNLNDRLASYLDKVRALEAANADLEVKIRDWHLKQSPASPERDYSAYYKTIEELRIKILEATTDNNRIILEIDNARLAADDFRLKYENELTLRQSVEADINGLRRVLDELTLAKTDLEMQIESLNEELAYLKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEALAEKNRRDAEEWFQTKSAELNKEVSSNAEMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLESTLAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMTGFNSGGNNTTTSNGSPSSNSGRPDFRKY
Protein: Serine protease inhibitor Cvsi-2 (B9A8D7)
Organism: Crassostrea virginica (Eastern oyster)
Function: Slow-binding inhibitor of serine proteases. The inhibitor rapidly binds to the protease forming a weak enzyme-inhibitor complex, and this is followed by a slow isomerization forming a tight-binding enzyme-inhibitor complex. Active against subtilisin A with a dissociation constant of 0.18 nM. Active against perkinsin. Not active against thermolysin, papain or pepsin.
Subcellular location: Secreted {ECO:0000269|PubMed:19464375}.
Interaction partners:
Sequence:
MKVAVVVALLCFVCYTAAETCSADGDCKNTICDASHDLECHRGQCTCVNHATACSSAADCSGSCTIFGRHGRWHCVDAKCRCFFV
Protein: Tail sheath protein (H9C1A2)
Organism: Pectobacterium phage ZF40 (Bacteriophage ZF40)
Interaction partners:
Sequence:
MAYPVDNIIPVNVLLTPAGLGYADFSSAIVFADAADLVTGVTFAVDTFRDYSSVTDVAADFKTDSDIYRIATRYFANTPKPPTITVWMKNATDTILEIINSANDRIWRYHYFLKNADVTAAILPDLSDWSDAASHPLWFTFSADNIIDQNVTSDVISALKSKGNRHVFAGYKSAASVTADASQAYAMVQLAAAFHKFRPTGINTAITGEYQVLPGVSGDDLTTSAYNALKAKNAVFFTQIELAGETDNSRVINSKSMSSYGEFIDDVVNLDVLKNHIQVDGYNYIANAGSKRAMTPRDYAGLLSAVSATCKRFFDNGVLGSGSYVDPDDGKTKVAQFGFVLRSSPEDVLDMTSAQCKARVYPPTSILVILARAGHVAEININVE
Protein: Cyclin-dependent kinase-like 5 (A0A8I6G3S6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKIPNIGNVMNKFEILGVVGEGKLKFHETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSTKRKPYHVESSTLSNRSQSTKGGALQTHHRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSSTRSQQNRHSFMESSQSKAGTLQPSEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETNTSRYFPSSCLDLNSPTSPTPTRHTDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGIDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARPSVKESSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSDSSSGTNHSKRQPGFDPWKSPENISHSDQLKEKEKQGFFRSMKKKKKKTQTVPNTDGPDLLTLQKAIHSSSTASSRPKEWRPEKLSDLQTQSQPLKSLRKLLHLSSSTNHPASSDPRFQPLTAQQAKNSFSEIRIHPLSQASGGSSNIRQEPTPKGRPALQLPDSPTYWFPGPQPQRTYWLHKRRVAKTFVER
Protein: CD2AP/CMS (Q80ZE7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MVDYIVEYDYGAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEPKDDNLPIKRERPGNVASLVQRISTYGLPAGGIQPHPQTKAMKKKTKKRQCKVLFEYSPQNEDELELTVGDVIDVIKEVEEGWWSGTLNNKLGLFPSNFVKELESTDDGEMHDAQEESEVSLTGPTSPMPSPGNGSEPAPGSVTQPKKIRGVGFGDIFEQGSVKLRTRTSSSETEEKKSEKPLILQSLGSRTQNVEVTKPDIDGKIKAKEYCKTVFPYTGTNEDELTFREGEIIHLISKETGEAGWWKGELNGKEGVFPDNFAVQISELDKDFPKPKKPPPPAKGPAPKPDPLAGEKKTFPLKAEDRDEKSLLEQKPSKPAAPQVPPKKPTPPTKANNLLRSPGTMYPKRPEKPVPPPPPTAKINGEVSTISSKIDTEPLSKPKLDPEQLPVRPKSVDLDALVARNSKETDNVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTQSPEKTLKLPKDDDSGNIKPSEFKKDAGYSSKPSLSAPSSASKVNTAAFLSPLELKAKVEADDGTKSSLDELRAQITELLCIVDALKKDHGKELEKLRRELEEEKAMRSNLEVEIAKLKKAVLLS
Protein: UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-galactose 4-epimerase) (Q8R059)
Organism: Mus musculus (Mouse)
Function: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Interaction partners:
- Galactose-1-phosphate uridylyltransferase
- Galactokinase
- UDP-glucose 6-dehydrogenase
- UTP--glucose-1-phosphate uridylyltransferase
- N-acetylgalactosamine kinase
- Galactose mutarotase
- Beta-1,4-galactosyltransferase 1
- Alpha-lactalbumin
- Beta-1,4-galactosyltransferase 2
- UDP-N-acetylhexosamine pyrophosphorylase
Sequence:
MEKVLVTGGAGYIGSHTVLELLEAGYSPVVIDNFHNAIRGEDSMPESLRRVQELTGRSVEFEEMDILDQAALQHLFKKHSFKAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMRAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCRADTAWNAVLLRYFNPIGAHASGRIGEDPQGIPNNLMPYVSQVAIGRREALNVFGDDYATEDGTGVRDYIHVVDLAKGHIAALKKLKEQCGCRTYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAHEELGWTAALGLDRMCEDLWRWQKQNPSGFGAQA
Protein: Small polypeptide ROTUNDIFOLIA LIKE 3 (OsRTFL3) (Small polypeptide ROT-FOUR-LIKE 3) (A0A5S6RB44)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Small polypeptide acting as a regulatory molecule which coordinates cellular responses required for differentiation, growth and development, probably by restricting polar cell proliferation in lateral organs (e.g. leaves and petioles).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q7XXN8}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEDERWKLSSSKGRSKSGRSCSSSSNYYYHSSDFNSSNATTLSRSYSASVTASRHATTAWSAAGAGGGGASSSSSSQHQHQQQQQQSNNSQRLSKKCVEAVKEHRARFYIVRRCVSMLVCWRDY
Protein: TATA-box binding protein associated factor 11 (A0A3B3ITY8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDDAHESPSDKGGETGESDETAAVPGDPGATDTDGIPEETDGDADVDLKEAAAEEGELESQDVSDLTTVEREDSSLLNPAAKKLKIDTKEKKEKKQKVDEDEIQKMQILVSSFSEEQLNRYEMYRRSAFPKAAIKRLIQSITGTSVSQNVVIAMSGISKVFVGEVVEEAQGERSRLCIFCSGLCSFLLPKVKIQEKQSQG
Protein: Microtubule-associated protein 4 (MAP-4) (Q5M7W5)
Organism: Rattus norvegicus (Rat)
Function: Non-neuronal microtubule-associated protein. Promotes microtubule assembly (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P27816}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:P27816}. Note=Recruitment to microtubule is inhibited by microtubules polyglutamylation. {ECO:0000250|UniProtKB:P27816}.
Interaction partners:
Sequence:
MADLSLVDALTEPPPEIEGEIKRDFMAALEAEPYDDIVGETVEKTEFIPLLDGDEKSGNSESKRKPCVDTSQVEDIPSSKPTLLANGDHGVEGNNTTGSPTDFLVENVDYEDYQNSQSWPEDASFCFQPQQVLDTNQADPFNVHHDDGLADLLFVSSGPTNASAFIEENNPLEDSYGVLPCDSFAPTAVVSQEWSVGAPDSPHSEPCVSPEVTIETAQPATELSKAVDLESVKEQLPAKALEMMAGQTTDAVPSKESEGSPDTDAAPGPDTDVTLTKDIEESSSPDVISANVTQPFTESDMFLTQEMELLIGTEAAQVKDTMSSVEPDISSAKNTAPPTEEETVPGKDMTFPKEAETALPIEMDLAPPEDVALPKETELELAPAAGTAPLSETEVALAKDEEPSTGIPAAQEMLLSSETEVVLPSDSIMTLTKEVTVPLEAAGPLVSDMTAILETEMTLGGGTATPTETKLGKVKDMAPLPESEVALGKDVVTLPETKVTEFNNVTPLSEEEVASIKDVSPSPETETAKNADLHSGTELTLDNSMTPPSDPALPLETKVATVQIKDKETVQTQEELSEDSQLESVQLEGQSAVPPCTISPEPVKAADQKSTLPVDEGSPLEKLEQKETSGSQPPELCSGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPLATTQPAKTSTSKAKIQPTSLPKQPAPTTSGGLNKKPMSLASGSVPAAPHKRPAAATATARPSTLPARDLKPKPITETKVAEKRTSPSKPSSAPALRPGPKTTPTISKATSPSTLVSTGSSSRSPSTTLPKRPTTTKTEGKPADVKRMTAKSATADLSRSKTTSASSVKRNTTPTGATPPAGMASTRVKPMSAPCRSSVALSVDKKPTSTKPSSSAPRVSRLATTVSAPDLKSVRSKVGSTENMKHQPGGGRVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGTVKTEGGGSEAPPCPGPPAGEEPAIPEAAPDAGAPTSASGLSGHTTLSGGGDQREPQTLDSQIQETSI
Protein: Arginine ADP-riboxanase CopC (EC 4.3.99.-) (Q7NWF2)
Organism: Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / CCUG 213 / NBRC 12614 / NCIMB 9131 / NCTC 9757 / MK)
Function: ADP-riboxanase effector that inhibits host cell programmed cell death. Acts by mediating arginine ADP-riboxanation of host caspases (CASP3, CASP7, CASP8 and CASP9), blocking their processing and activation. ADP-riboxanation of host apoptotic caspases (CASP3, CASP7, CASP8 and CASP9) prevents their activation, thereby inhibiting host cell apoptosis. ADP-riboxanation of host CASP8 also inhibits host cell necroptosis. ADP-riboxanation of host CASP3 also abolishes pyroptosis by preventing its ability to cleave GSDME. May also able to inactivate CASP4/CASP11, blocking inhibiting LPS-induced pyroptosis; however this activity is unsure in vivo. ADP-riboxanation takes place in two steps: CopC first catalyzes ADP-ribosylation of target Arg, and then initiates a deamination to remove one N-omega group.
Subcellular location: Secreted {ECO:0000250|UniProtKB:A0A0H2US87}. Host cytoplasm {ECO:0000250|UniProtKB:A0A0H2US87}. Note=Secreted via the type III secretion system (T3SS). {ECO:0000250|UniProtKB:A0A0H2US87}.
Interaction partners:
Sequence:
MRVENHSPSLSKLNPPEAGSGDPTAIGRRLSGIRRAPLPHVSAGSDGEAAAAGKIGAFLRKAVAAQSYGLMFANGKLFEATGDALEKRGQYGFSALQRLDGLSRRNLAAVEARLGALDSAERGLKERIMTGAWHFRHQSNAALDDGKTAAIASNHLLARESRSSGGNTFAGDKALLSNHDFVFFGVEFSGRGKQDKPLNHKHSTMDFGANAYVVPDTLPACRHGYLTLTDHFFNRVPGGREAEHQDFVGSFPQMGAETGRWIHEGKYRQNAPIFNYRDMKAAVALHLIEFLRDSKDAAFKAYVFDQAMQSGQALDRVLNSVFQAEFHIPRLMATTDYAKHPLRPMLLKEAVDSVNLPALSGLVSSKGDAVTAMWHAIDKGKDAVAAHLLGNWRFEAGDFASAPPGFYHELNYALSEHGASVYILDQFLSRGWAAVNAPFEHVNSGETMLDNAVKYGNREMAAALIKHGADRNLLSEWNGGKLDALLA
Protein: MIP22165p (D5SHN1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MPVLEVSIYTLLKMAFIWQLISAAIYLVGLLTIGVFLYDNLKSLVSIIKAVLEPYFQPHLPRTLVDKFGQWAVVTGATDGIGKEYARELARQGINLVLISRTKEKLIAVTNEIESQYKVKTKWIAADFAKGREVYDQIEKELAGIDVGILVNNVGMMYEHPESLDLVSEDLLWNLLTVNMGSVTMLTRKILPQMIGRRKGAIVNLGSSSELQPLPNMTVYAASKKFVTYFSKALELEVAEHNIHVQLVMPNFVVTKMNAYTDRVMQGGLFFPNAYTFARSAVFTLGKTSETNGFWTHGIQYAIMKLAPLPIRTYLGHQLFKRLRIEALEQKQKKLKLT
Protein: Methylosome protein WDR77 (Methylosome protein 50) (WD repeat-containing protein 77) (A0A024R0H7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE