wanglab/gogpt-training-data huggingface dataset:
Protein: Probable galactinol--sucrose galactosyltransferase 2 (EC 2.4.1.82) (Protein SEED IMBIBITION 2) (Raffinose synthase 2) (Q94A08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transglycosidase operating by a ping-pong reaction mechanism. Involved in the synthesis of raffinose, a major soluble carbohydrate in seeds, roots and tubers (By similarity).
Interaction partners:
- Alpha-galactosidase 2
- Alpha-galactosidase 1
- Alpha-galactosidase 3
- Galactinol synthase 2
- alpha-D-xyloside xylohydrolase
- Galactinol synthase 1
- Galactinol synthase 3
- Galactinol synthase 10
- Galactinol synthase 6
- Galactinol synthase 4
Sequence:
MTITSNISVQNDNLVVQGKTILTKIPDNIILTPVTGNGFVSGSFIGATFEQSKSLHVFPIGVLEGLRFMCCFRFKLWWMTQRMGSCGKDIPLETQFMLLESKDEVEGNGDDAPTVYTVFLPLLEGQFRAVLQGNEKNEIEICFESGDKAVETSQGTHLVYVHAGTNPFEVIRQSVKAVERHMQTFHHREKKKLPSFLDWFGWCTWDAFYTDVTAEGVDEGLKSLSEGGTPPKFLIIDDGWQQIENKEKDENCVVQEGAQFATRLVGIKENAKFQKSDQKDTQVSGLKSVVDNAKQRHNVKQVYAWHALAGYWGGVKPAASGMEHYDSALAYPVQSPGVLGNQPDIVMDSLAVHGLGLVNPKKVFNFYNELHSYLASCGIDGVKVDVQNIIETLGAGLGGRVSLTRSYQQALEASIARNFTDNGCISCMCHNTDGLYSAKQTAIVRASDDFYPRDPASHTIHIASVAYNSLFLGEFMQPDWDMFHSLHPTAEYHAAARAVGGCAIYVSDKPGNHNFDLLRKLVLPDGSVLRAKLPGRPTRDCLFADPARDGISLLKIWNMNKFTGIVGVFNCQGAGWCKETKKNQIHDTSPGTLTGSIRADDADLISQVAGEDWSGDSIVYAYRSGEVVRLPKGASIPLTLKVLEYELFHISPLKEITENISFAPIGLVDMFNSSGAIESIDINHVTDKNPEFFDGEISSASPALSDNRSPTALVSVSVRGCGRFGAYSSQRPLKCAVESTETDFTYDAEVGLVTLNLPVTREEMFRWHVEILV
Protein: Heterogeneous nuclear ribonucleoprotein U-like protein 2 (MLF1-associated nuclear protein) (Q00PI9)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000269|PubMed:17008314}.
Interaction partners:
- Galanin-like peptide
- Serine/threonine-protein kinase A-Raf
- Heterogeneous nuclear ribonucleoprotein A0
- Protein FAM98A
Sequence:
MEVKRLKVTELRSELQRRGLDSRGLKMDLAQRLQEALDAEMLEDEAGVGGAGPGGACKAEPRPVAASGGGPGGDEEEEDDDEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPETSAMEAESEASDTPAEATAGSGGVNGGEEHDNGKGEEDGPEERSGDETPGSEAPGDKAVEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPPPPEEEAKDEEEDQTLVNLDTYTSDLHFQISKDRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQNLPMKEGCTEVSLLRVGWSVDFSCSQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDVIGCFANFETEEVELSFSKNGEDLGVAFRISKESLADRALLPHVLCKNCVVELNFGQKEEPFFPPPEEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKDNPERRYNVLGAETVLTQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRSKRNFILDQCNVYNSGQRRKLLLFKTFSRKVVVVVPNEEDWKRRLELRKEVEGDDVPESIMLEMKANFSLPEKCDYMDEVTYGELEKEEAQPIVTKYKEEARKLLPPSEKRTNRRNNRNKRNRQNRSRGQGYVGGQRRGYDNRAYGQQYWGQSGNRGGYRNFYDRYRGDYERFYSRDYEYNRYRDYYRQYNRDWQNYYYHHQQDRDRYYRNYYGYQGYR
Protein: CYtochrome P450 family (O02627)
Organism: Caenorhabditis elegans
Interaction partners:
- Fatty acid synthase
Sequence:
MFLVLIFLALSCWLIIRQYQKVSRLPPGPVSFPIIGNLPHIIYYLWATGGIVSTLDLFRKKYGNIFTLWVGPVPHVSICDYETSHEVFVKGANKYADIAHAPLFRELRQEMGVLVTNGSHWSTMKRFALHTFRDMGVGKDLMETRIMEELDARCADTDKSATDGVTVAQAGDFFDLTVGSIINSILVGKRFEEHNKDDFLKIKEAMGAAFEVFSPFDMAVPVWFLRTFFRSRYDMMMTTQNTAKRFAAAEAVKRIEDIKSGAYEIDESNIEDYTDAFLLKIQKDGEDLDFNIETLKTMIIDLWMTGQETTTTTLISGFTQLLLHPEVMVKAREEILKITENGSRHLSLTDRTSTPYLNAMIGEIQRHASILNVSFWKINKELTYMGGHPVDAGALVTAQLSALHVNDTIFKNPQEFDPERFIRDEELLQKVIPFGVGKRSCIGESLARAELYLIIGNLLLRYKFEPHGTLSTTELLPYSAGKRPFKLEMKFVKI
Protein: Tomosyn, isoform K (Tomosyn, isoform L) (Q9VYK5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAIGDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVTVTADDTIHLWSIRQKTPRIVQSLKFQRERVTCIHLPVGSKWLYVGTEKGNIHVVHIDTFALSGYIINWNKAIEVVRTSHPGAVIALCDNPLDANKLLIAFECGLLVLWDLKAKCAELRWQAAEAVKSLAWHYEGKYFVSSHTDGSICSWPTKPQAKPQSQVCPHAKINKDGNAEKCKPIYKVDLKSSATGETFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEHAVCDFITLCENPWPCETQEPYAIAVLLQYDLVLIDLLTPGFPCFESPYPMDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSEREWPISGGEWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSHVAHSHPESDNPLAVHLIFLCSESRRLCVAGAMGQVMLFKFRKVESTSEVLVLEIPILYENFDDIYGTSPECDFLTGHQVQKAESSDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNRRNVQVTSLCISSSYGLMAYGTEYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIENKEEQSRSPSSDQINGSGVATAAPQQQQQQQQQLQQSQQQQQQQLQQQQQQQQQQQQQQQQQQQSLGGDPGDHATSTSAGAATLAGSSIYGADDAGAGVASGGVGVGGISSAISGGFGGAAEPQQQQQVSQQLHQLQQLQQQSQQQQQSFEASCDPWGGECGGGGAGGSGGGGGASGGGGASGAGAQQHQYQHPHPYPHPHPYPHQTSVIQQQQSVTSYESLKKSKSQDKLDGTFSRSRSSSMSSIDMSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPERDVRKSQPVLITINGGPVVRLKGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFTPTTANTLSNTSVAGGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTSGGGMSSSSASSSGISGSVSTGLETLTDRQYIVIASEKQTKVFDVANQCCINRIQLSEMDFAVKAETITMKDGSCLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQGIVDPMLSIWGQQIIVHEDTTQISKIFCFSHKGHGLYMASPTEIQKFTISSEFCQFILEMMGELYTVHEMPEQPKEGFFKGLFGGGAKLLDREELFGEQSGKPNRSVARHIPGPNLEQLGQRASTAASEISRAHQLAMERGEKLNLLEERAERMANTAQDFSGTAHQLMLKYKDKKWYQL
Protein: Degradation enzyme regulation protein DegQ (Regulatory factor SacQ) (Q99039)
Organism: Bacillus subtilis (strain 168)
Function: Stimulates the phosphotransfer from phospho-DegS to DegU. Affects protease and levansucrose production.
Interaction partners:
- Sensor histidine kinase ComP
- Signal transduction histidine-protein kinase/phosphatase DegS
- Tryptophan prenyltransferase ComQ
- Regulatory protein DegR
- Uncharacterized protein YwtC
- Surfactin synthase subunit 1
Sequence:
MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMKIS
Protein: MIP34848p1 (Senescence marker protein-30, isoform C (EC 3.1.1.17)) (H8F4T3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Desaturase 2
- EG:BACR7A4.14 protein
- Sorbitol dehydrogenase
Sequence:
MTQMSYKVEAVPDSYAALGEGPHWDVDRQSLYYVDLESAGINRYDFKQNKVYRAKIEGEIFASFILPVENKPQEFAVGCGLRTVIVQWDGVSAVAKVTRTLFEVQPDLKENRLNDAKTDPNGRFYGGTMADSGDIFTQWKGELYSWQAGGQPNAIRSKVGISNGLAWDVKAKKFYFIDTNNHEVLAYDYNQSTGAVSNPKVIFDLRKIRPEGPLFPDGMTVDTDGNIYVATFNGGTVFKVNPSTGKILLEIKIPTTQITSVAFGGPNLDILYVTTANKFDQPKPAGTTFQVTGLNAKGYAGVNLKI
Protein: Uncharacterized protein (Q4WE83)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
Sequence:
MSKLLSQGGVELADRYAPLWFFGQAQKQPPCYPTWAFGGSPTSSDIYDDAHKTPPAPQCEYPNVGCRCRNPGVGIGNRGPPFPIYFTYKRCSDTEVRVVYNLFYEKDGADVIGIETGHDYDWERVIIIHSRDANNMWAPTRALLSAHSGYHDLAWGDIQNTLTTDEINAGDAKNPNGVQNNDHPKVYVAWSKHAHFDDRNTGWNDPISQSTDNAFRSDDWWYYVDKSYYILSDDTTAAGKALGSANWGDATSNPPSVHASVCSAP
Protein: Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) (Q9BX66)
Organism: Homo sapiens (Human)
Function: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
Subcellular location: Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. {ECO:0000250}.
Interaction partners:
- Vinculin
- Afadin
- HLA class I histocompatibility antigen, C alpha chain
- E3 ubiquitin-protein ligase CBL
- Flotillin-1
- Spartin
- Talin-1
- Paxillin
- Teneurin-1
- E3 ubiquitin-protein ligase TRIM45
Sequence:
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMDLTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPSSLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Protein: UBX domain protein 8 (A0A087WT23)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLYSGTWRTVGIRCPRKKAQICQQQECCIERPPLRLRGFGAALTTTPRLHRPCPPTSGADFTSRNLFPPGIKDFLLLCGRILLLLALLTLTISVTTSWLNSFKSPQVYLKEEEEKNEKRQKLVRKKQQEAQGEKASRYIENVLKPHQEMKLRKLEERFYQMTGEAWKLSSGHKLGGDEGTSQTSFETSNREAAKSQNLPKPLTEFPSPAEQPTCKEIPDLPEEPSQTAEEVVTVALRCPSGNVLRRRFLKSYSSQVLFDWMTRIGYHISLYSLSTSFPRRPLAVEGGQSLEDIGITVDTVLILEEKEQTN
Protein: Tyrosine-protein kinase RYK (EC 2.7.10.1) (P34925)
Organism: Homo sapiens (Human)
Function: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000250}.
Interaction partners:
- Protein Wnt-5a
- Protein Wnt-11
- Protein Wnt-5b
- Frizzled-1
- Frizzled-4
- Protein Wnt-3a
- Protein Wnt-7a
- Frizzled-5
- Frizzled-2
- Frizzled-8
Sequence:
MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV
Protein: microtubule-severing ATPase (EC 5.6.1.1) (A0A2R8YFW8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAKMMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARTKTRTGEEYVCQ
Protein: Large ribosomal subunit protein mL42 (Q7K0A0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- GEO10172p1
- Large ribosomal subunit protein mL66
- Small ribosomal subunit protein mS33
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein mS29
- GH07821p
- Small ribosomal subunit protein bS16m
- 28S ribosomal protein S14
- GH05406p
- Small ribosomal subunit protein uS12m
Sequence:
MSAARLYGGFRLFSSSAVQRNAVGGKSLVEAVAVTKNGRTIVAWHPDTPVPYENTLPLPEISEIQSSAVVKESALKTAMRAFKSKHPEVARQELMQLTHTTKHRWFPRARDRKAKQTPMDRPYL
Protein: Miltiradiene synthase KSL1, chloroplastic (EC 4.2.3.131) (Kaurene synthase 1) (IrKSL1) (Terpene synthase 4) (IrTPS4) (A0A1W6QDI7)
Organism: Isodon rubescens (Rabdosia rubescens)
Function: Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities. Catalyzes the conversion of (+)-copalyl diphosphate ((+)-CPP) to miltiradiene.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MSLAFNLRVIPFSGHTIQSRRGLFPVHESPMITTKPFAAVKCSLTTSTDLMGKIKEKFNGKVHTSLPAITTHSADTPSNLCIIDTLQRLGVDRYFQSEIDSILDDTYRLWQLKKEDIFSDITTHAMAFRLLRVKGYQVSSEELAPYADQEHVNLQEIDVPTVIELYRAAQERVTEEDSTLKKLYVWTSTFLKQQLLTDAIPDKKLHEQVDYYLKNYHGILDRMGVRRSLDLYDVGHYKTLKAADGFSNLCNEDFLAFARQDFNISQAQHQKELQQLQRWYSDCRLDTLKFGRDVVRVSNFLTSAMSGDPELSDVRLAFAKHIVLVTRIDDFFDHGGSKEESYKILELVKEWKEKPAGEYGSEEVEILFTAVYNTVNELAEMAHIEQGRSVKDLLIKLWVEILSMFKIELDTWSDDTALTLDEYLSSSWVSIGCRICILISMQFLGVKLTDEMLLSEECTDLCRHVSMVDRLLNDVQTFEKERKENTGNSVSLLLAAHKDERAINEEEAITKAKDLAEYNRRKLMQIVYKTGTIFPRKCKDMFLKVCRIGCYLYSSGDEFTTPQQMMEDMKSLVYEPLTIHPPEANNVVGKKTELCQQLVKPYVCHTFCKKYTVSRPSNVMMTCYID
Protein: Uncharacterized protein (O25546)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- NYN domain-containing protein
Sequence:
MMNGISRIYFYTTPPFDFEHALWDKRNDTLQNEKNPGTEMKIFTSSDIEEILQSSEATKWEKIYSDVENFQHDLASLDQVELRLGRTKLNAIRVEFDGSYRALLEQKQVDMLMGLDIQRIAFKKIADRILIFSKDTDLIPALKLARDEGLRVDIADLSNRLSLLSQDLKYNSDKVRKLSSNEVKDKLFSIRENLTKTNWALN
Protein: FCS-Like Zinc finger 6 (Q9SGZ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway. Negatively regulates KIN10 leading to a repression of the SnRK1 signaling pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:24600465, ECO:0000269|PubMed:29406622}. Cytoplasm {ECO:0000269|PubMed:24600465, ECO:0000269|PubMed:29406622}. Endoplasmic reticulum {ECO:0000269|PubMed:29406622}. Note=Shuttles from the cytoplasm to the nucleus when associated with KIN10 (PubMed:24600465). Co-localized with ER marker when associated with KIN11 (PubMed:29406622). {ECO:0000269|PubMed:24600465, ECO:0000269|PubMed:29406622}.
Interaction partners:
- FCS-Like Zinc finger 16
- Leucine-rich repeat protein kinase family protein
- SNF1-related protein kinase catalytic subunit alpha KIN10
Sequence:
MLLGKRQRPPINRTTSLSEIKFDLNLPSESEPSNQQKPTVASPYGSNGQAVTAAVDQNRGFLDQRLLSMVTPRGNLRRHSGDFSDAGHFLRSCALCERLLVPGRDIYMYRGDKAFCSSECRQEQMAQDERKEKGKSAAPAKEPAVTAPARAKPGKGRAAAAV
Protein: Mitogen-activated protein kinase SLT2/MPK1 (MAP kinase MPK1) (EC 2.7.11.24) (Q00772)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the SLT2/MPK1 kinase which itself then phosphorylates and activates the transcription factor RLM1. Directly phosphorylates BCY1 upon TOR complex 1 (TORC1) inhibition.
Interaction partners:
- Transcription factor RLM1
- Tyrosine-protein phosphatase MSG5
- MAP kinase kinase MKK1/SSP32
- Regulatory protein SWI4
- MAP kinase kinase MKK2/SSP33
- Dual-specificity protein phosphatase SDP1
- Regulatory protein SWI6
- Protein SPA2
- Tyrosine-protein phosphatase 3
- Serine/threonine-protein kinase BCK1/SLK1/SSP31
Sequence:
MADKIERHTFKVFNQDFSVDKRFQLIKEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFRGHKNITCLYDMDIVFYPDGSINGLYLYEELMECDMHQIIKSGQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSENPVENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDETLRRIGSKNVQDYIHQLGFIPKVPFVNLYPNANSQALDLLEQMLAFDPQKRITVDEALEHPYLSIWHDPADEPVCSEKFEFSFESVNDMEDLKQMVIQEVQDFRLFVRQPLLEEQRQLQLQQQQQQQQQQQQQQQQPSDVDNGNAAASEENYPKQMATSNSVAPQQESFGIHSQNLPRHDADFPPRPQESMMEMRPATGNTADIPPQNDNGTLLDLEKELEFGLDRKYF
Protein: Spermidine sinapoyl-CoA acyltransferase (AtSDT) (Spermidine disinapoyl transferase) (EC 2.3.1.248) (O80467)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Spermidine sinapoyl-CoA acyltransferase that mediates the accumulation of disinapoyl spermidine conjugates in seeds. Catalyzes the two conjugating steps required for the biosynthesis of N1,N8-disipanoyl-spermidine. Can also use putrescine as an acyl acceptor to convert it into monosinapoyl-putrescine.
Interaction partners:
- NAC domain-containing protein 6
- Uncharacterized protein
- At2g45350/F14N22.7
- Zinc finger
- At3g13230
- Phosphoglycerate mutase family protein
- Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein
- At3g15680
- ALC-interacting protein 1
- Glycine-rich protein
Sequence:
MPIHIGSSIPLMVEKMLTEMVKPSKHIPQQTLNLSTLDNDPYNEVIYKACYVFKAKNVADDDNRPEALLREALSDLLGYYYPLSGSLKRQESDRKLQLSCGGDGGGVPFTVATANVELSSLKNLENIDSDTALNFLPVLHVDIDGYRPFALQVTKFECGGFILGMAMSHAMCDGYGEGHIMCALTDLAGGKKKPMVTPIWERERLVGKPEDDQPPFVPGDDTAASPYLPTDDWVTEKITIRADSIRRLKEATLKEYDFSNETITTFEVIGAYLWKSRVKALNLDRDGVTVLGLSVGIRNVVDPPLPDGYYGNAYIDMYVPLTAREVEEFTISDIVKLIKEAKRNAHDKDYLQEELANTEKIIKMNLTIKGKKDGLFCLTDWRNIGIFGSMDFGWDEPVNIVPVVPSETARTVNMFMRPSRLESDMVGGVQIVVTLPRIAMVKFKEEMEALE
Protein: Leucine-rich repeat-containing protein 4C (Netrin-G1 ligand) (NGL-1) (Q9HCJ2)
Organism: Homo sapiens (Human)
Function: May promote neurite outgrowth of developing thalamic neurons.
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}; Single-pass type I membrane protein {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}.
Interaction partners:
- Netrin-G2
- Netrin-G1
- Disks large homolog 4
- Whirlin
- Unconventional myosin-XV
Sequence:
MLNKMTLHPQQIMIGPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTKIIIGCFVAITLMAAVMLVIFYKMRKQHHRQNHHAPTRTVEIINVDDEITGDTPMESHLPMPAIEHEHLNHYNSYKSPFNHTTTVNTINSIHSSVHEPLLIRMNSKDNVQETQI
Protein: FI18705p1 (Sanpodo protein) (Tropomodulin, isoform A) (O46231)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
METSATTKTTTLTTPAKLYGKDLSEYDDVDVESLLAQLSPEEITILAKEVDPDDNFLPPDQRNSYECTKEATGPLNRKQLIEHINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEEIIDLAAILGFHSMMNQDQYHASLLNKGQPVGLGWDGITKSTQQKLFPMDPPNNTDVEESIKRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGLHLEFNDARHRVAAHLQRNIDRIRVKRLNQRK
Protein: Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) (Q00534)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases.
Subcellular location: Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23918663}. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). {ECO:0000250|UniProtKB:Q64261, ECO:0000269|PubMed:23918663}.
Interaction partners:
- G1/S-specific cyclin-D3
- Cyclin-dependent kinase inhibitor 1
- Cyclin-dependent kinase 4 inhibitor C
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase 4 inhibitor B
- G1/S-specific cyclin-E1
- Cyclin-L2
- Cyclin-dependent kinase 4 inhibitor D
- G1/S-specific cyclin-D1
- Cyclin-A2
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
Protein: Ring finger protein 38 (A0A8I5XVZ9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MASHELSFSSPSFSQISPGANSAPLPGHPNKVICERVRLPSLFPLLPSDQDTTIQEDAHFKAFFQSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVRPNQHHFSGERCNTPARNRRSPPVRRQRGRRERLSRHNSISQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLLHPPHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLQVGSFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPVPPPTYHPSLLPYVLSMLPVPPTVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPSNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKGNRTCPICRADASEVHRDSE
Protein: Protein PLM2 (Plasmid maintenance protein 2) (Q04383)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds to the promoters of genes with functions important for the G1/S (start) transition; primarily genes involved in DNA synthesis and repair, chromosome segregation, nuclear division and transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cyclin-dependent kinase 1
Sequence:
MSHLFPPSSPVAGKPLESPQKEPGKLANTSVLTLGRKRYNYELEEYPTPDPSSSIGRQSSPVKDITSRLNETKSALSSPSKQEKVLAGPIEIELDASDPSRLAIGRKKSVCNIILPCRKNISRQHAFISYAADRNEIKLECNGTNGLSVHLPYSMQLHLVKPFPTRNFYKLVAEEPLTSQNTKQSHGKTLQKNQNFISFVLAKGETVTFPYIQGSFINFTGVTVCLSLKKVAPYPGDGNNNFDEENSTETEDELCLLTTTSDDFSWQKETPSMKFVPVEHSPRTEQISKPLLIASPALVKNSPISYRTTPQTSFVINQPSTPKKLKRKSISLKNNTIQETPLPKDKIIGTLSASTRSGGINEEESFAAVAKKTKELSSTTAIVSPAQKRLKTSLNIIPEISRSLSERGIRFDDLVHVLCNHLAFSNLQQTPLSQLQNINSNTSQLSKDELKKVLETISCIGIIVREGKDASGKPLEDEYYYDVENDDSDERKILYNSLKGRSRLRSCRKKHKQYFWKRPTK