wanglab/gogpt-training-data huggingface dataset:
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q38CT8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MYWVVVLLTVLHSCHRALGKEDIVNQKEFEALCRMINWAEERLEHIKVTKRVTQEALKIGVRYLEVAGEEECRHIAKAQEDSCTKKMEDRKRNCGLYKNFWEEAQKAVKERAFSGEKLERKIDALGEHTVDEIKKKGMYGADIYHDVEAKRPSGNMRKMEEHLIKALYGMEYFSEDIKGGDSDRSRVCGQNLRNNKATGGWSLAVDLLCLCATHNSWKGRKKVCCADCSTGENRDEWNPESNEAPRWDFLKQKCAGRHRNRHDMIEKLSEAEENLMKTVTKIGTIPYTHTYVLGTAVNSRIKPCGADINKQQEICVHYGSDNGTKLPWLKALQKVEKEMKLTLKDKQDKSAKLKRMEELNQEIESLIRGDTGRGGQRGRQKRSVNPENSVPETPADPSDPTQSVPHTNEKKRSVRKPISTGNGATKSYNSEEDDSYEYECEGENSACSDSPAKPTVKNSKSAINCPLGLILLLV
Protein: RNA binding protein, putative (Q387S7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNYADGNYYDSQQAAGYYYPEGQQVDDGYTIDLRPPDITEQQDNIIQLVAKYVVASCDGARYQNKLMKKTKFNSYFAFLASPEHKYHEYYQYLVRSYTHWRHVAAASAANQDNNEGYAFYTEQLQQQMYDANMYYAHAYNIAAADNLAASASAVVGTATGGYYDANSAFPLHNQQPQPEPLSGKSVLGNASDAISQPLGEAESRKRARSATPLESSDDEEEDQGVEFVMENGVARAVPRRS
Protein: LD37257p (RING-associated factor 2, isoform A) (RING-associated factor 2, isoform B) (RING-associated factor 2, isoform C) (Q9VV52)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- JmjC domain-containing histone demethylation protein 1
- GH15225p
- Polycomb group RING finger protein 3
- E3 ubiquitin-protein ligase RING1
- Polycomb group protein Psc
- Protein suppressor 2 of zeste
- Polycomb protein esc
- Polycomb protein Sfmbt
- Polycomb protein Su
- Histone-lysine N-methyltransferase E
Sequence:
MSNEIYDSSNSQLSSDEYSHEEEEYDALMDAAVSKQRPQKTKSKGSESEKPGNGAPESAAATEKNEKPDDDAVPPSTRSETIRRIRQLQLQRGRLPNLYFKRRSIRWLRPNKMDYNSYFDGLKDLLPKRKLKHLVRFHDRQRRTYDSRSISRSRSHSRSLSRSCSRSRSRSYSRSRSGSGSPELICLDDTENEDSPEKPEQEPARVTPIKENKPTLPAPPQLNYELPERKKANPLGNNENGASILDEFLVKKDPQEPVFDYGKLSACRELEQALKDRSRDAPNEAESLVVDATLKRRRSVTPPASEEKRNNEVEDDNIIGFSTVQQQKPMEAAPPLNLRMPTTPSTNPLQRQQAFKLSTPYTLAPPTAAKQADTYSLNTPPPTATQMQISYPNEKLSNNMKANATFSIQQTALSQVAASYAAAPQVAALAQRAPSQVAPLQQAPVQQMHFPRSVPPQQLPPPQQRAPPQQLATAPFAPPRHLAQHRPSPQQLAPSQQLAPPHQLAPPHQLAPPQQRAPPQQLAPPHQLAPPHQLAPPQQRAPPQQLAPPQQLAPPQQLAPPQQLAPPQQLAPPQQRAPPQQRAPPQQLAPPQQRAPTQHMAPPQHMAPPQQLAPTQQLAPPPQQLAPRPQQLAPPPQQLAPPPQQLAPPPQQPDSSRPASVQPLTPQRHASPHQLAQSQQVHQSPSQLHPVPVAAPNFAVPQQPQPRRSETVSTQTQGLGSPAASSSTTRQKSFVDLNNSDANFHYRVKELFDELNSTMIDKINSVPPDEDSLKKERERIVADLAALDKLMAQKEDEYNRLLYLSCIKKELHERMERKERLIRIKDLLPILINKCGTKELSEVKAMLEEEIDSPMASKHSLSAIEKLLNYAELNQNIIQLLRGSLGLNKRAPSVSPANFEDDQMLFRRDSLPVSHLSMRDQHYESRNAVNDHLLDSNPDRDPPAKRPKLIHSQDSNQDMASSSTHLSANLSETLRKIRAWKNYSHFSNVSMEDNNSDNESQIEPLFNSSPMASRRQLANRQSYQEQHSANINDHENVQKRHKSHKRKSHKHKSHKHRSSHKSQAESSATINGNTGRQCHECKLYGATFMCSNCQNQWYCSRECQLSDWDTHHRTCGI
Protein: Bacteriocin BAC79 (C0HLU4)
Organism: Weissella confusa (Lactobacillus confusus)
Function: Has antibacterial activity against a wide spectrum of Gram-positive and Gram-negative bacteria, including L.monocytogenes which is inhibited through disruption of the cell membrane.
Interaction partners:
Sequence:
AIAVELARDVFEAIQTLSRGSVFQDMPLVSNKELMDLR
Protein: Protein DesVIII (Inactive cytochrome DesVIII) (Q9ZGH8)
Organism: Streptomyces venezuelae
Function: Involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomycin, and pikromycin. DesVIII assists the folding of the DesVII polypeptide. However, unlike chaperones, it remains bound to DesVII during catalysis, forming a tight DesVII/DesVIII complex. Although the formation of the DesVII/DesVIII complex is essential for the catalytic activity, DesVIII is unlikely to be involved in catalysis directly.
Interaction partners:
Sequence:
MTDDLTGALTQPPLGRTVRAVADRELGTHLLETRGIHWIHAANGDPYATVLRGQADDPYPAYERVRARGALSFSPTGSWVTADHALAASILCSTDFGVSGADGVPVPQQVLSYGEGCPLEREQVLPAAGDVPEGGQRAVVEGIHRETLEGLAPDPSASYAFELLGGFVRPAVTAAAAAVLGVPADRRADFADLLERLRPLSDSLLAPQSLRTVRAADGALAELTALLADSDDSPGALLSALGVTAAVQLTGNAVLALLAHPEQWRELCDRPGLAAAAVEETLRYDPPVQLDARVVRGETELAGRRLPAGAHVVVLTAATGRDPEVFTDPERFDLARPDAAAHLALHPAGPYGPVASLVRLQAEVALRTLAGRFPGLRQAGDVLRPRRAPVGRGPLSVPVSSS
Protein: Sporulation-specific protein 3 (Q9US08)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in spore morphogenesis. Involved in the assembly of the forespore membrane.
Subcellular location: Prospore membrane {ECO:0000269|PubMed:11739793}; Peripheral membrane protein {ECO:0000269|PubMed:11739793}. Note=Associated with forespore membrane.
Interaction partners:
- Uncharacterized protein C17D1.07c
- Membrane glycoprotein spo14
- Sporulation-specific protein 15
- Sporulation-specific protein 2
- Syntaxin-like protein psy1
- Meiotic expression up-regulated protein 14
- Sporulation-specific protein 6
- Sporulation-specific protein 13
- Sec14 cytosolic factor
- Cell cycle protein kinase spo4
Sequence:
MGILSVIRIFIYCLIRLFSFNSRKRNSSIDELERGEINAFACDKQNTPSPNSECRPLTPLNSPFRRTVEGDTANLQAPSPTACPSFDSASSIKSSKEDIACRKLSTERFFYSPNGIDEMKKQQQFKKIPTVSITEVEPAFIPSNMEQALFSEEPFVIQDDLSHQINLDDNRKFSRIQKNKLDPLITVNLVPIVNGENCFNFYETQMETNFLSPEFIKKPSMVDHKRDSEINAVTAVSADGSFSPLTETLSSTISTLSNDSLDGLSSQKNEFTGFNSNSEWIPNDTVDYICNSDASSVVSNLSDFEDCFDQFGVYDKEYEKKIEKTKRNFPKFQSSATYPPFSAHHQARRNNPQGFRNVKKRFQLFKDDCTALTDSDFLDALPFFNARVIIALYVEWRLRVYETMIIKGEESLKNLQRARDGPHNKLWLGVFGNKDTIKKLSNYDRRAISNPYVSNHLNFNVRRVKSDTVYIPTILQLLRSSTQLMTEQAFVASSNLKSTKGLRETRLIQKYKVKGDFEYVYAALYYAAFTQESTLKAVTIDDILSEDELEDWWYLNLRYTSFITPQLCFEFLDKEADSCRDRLTEVKSEPPKAVIYEEPLNKLSRFSSDRLFTSHELVAIAELISLNEPPLESGKKFYYEEFQKACQKKRDDYRYSPEIEFKAAFREKFLQSNEKVPFPRPGEIYEKRCDYFSKYACQNIFISKPLKRSGSIYEVFSDGIGRVIYGSVLDYEATRNNILLHFGFEIHCAPSEEELIEREEAFKDFHNMLSFKYSANEIYEFCGTHSRAEVHKNEVLKRMAYYLIDENKEISILRRILSLRIVEPTTSFTRYEYDLWRTFYPDVLYLNYSKSGRIPTGSPYIMNGQWRKDLCVSTPPMVDINSALFPHWFKLSASNLFAGAEHAGLNRQKPDKIDLDLYEPLPENSYLVAAELRVLRALRHKNPENIPLLEKWEVRALHQLMAKIRKYYTVPTDYLSLRMDGLQAMLRKREYMSCYTFNYFDYACLMDHAYRLYEGFNNQVVNLPPRIM
Protein: Ubiquitin-like domain-containing protein (Q55GG3)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MFFKKKKDSKDDIPTSPSPNTLAPPSGGFRIGSVSSGASTEQLDQIAQNKQKIPSLFRLLAEHKLSEKEIWEGDHMLFSILYQFKSQLNKTESPPNVITFHLPGIPEFGDIKKKSYKINKKFTIQQTIGLICKKQMIPDPKRFWIGSIQGFIMNDHETLASYGLSSLFESWELRLILKEDILSKSPYRYQPIESIGTEFIVVFELPPLEQFNGLKKQSVKVDSNQTIKQSIVNICKKYRVEEPDRFSAMTIDDNPLVEFVLFGGACFKHYGLGFKFKKWDLKIVFNDLIPPYVHRHTVIPMHGWTQVSPGQLDPMTARTIINDLEEKCQGYQAHIQKLNNDIDGGNQVSASHVAEIERLREEIKRLNQVIDEERESTSQQNEQYEGRLSSCNQEIESQSVQLKSLRGKVDEVCHLLSSLKAQHEELQSNYNVCKAEKEQLEQQLEESTNDVQEFKLKLSTAKSAAVESEQNFTAMIAQLEKEKAIIKEEVLRATSEKEDTEENVKSLQASQAVLVTQLQDDISSLTRDKELLALSMQKATLERKEAVVLQEKAEKKMVEMQSEKKRVERQFGDLERERDVLRQQVQIKVDEIQDVQKDLEWSRETVADLERRLVNLNGECQMFKDIKNKEVEKNKKSTSEESKSKNELEQEKQKTLTIQTQLNKKINDLLSKQKTQEAAFKNAEQLFKKRELELASEMQEFAEKYEQLKQSISNGSIKDGSTVPSLQVPTSLANIVGNHRQATTVGDSMVSSPLNLNENKPTVPSSSSSSSPDTDCQPKELSFIADGLYKSLQNRFQTTNKEGVEELELSSDSSDNEN
Protein: Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (F1REK1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRSDIMWMYQALLFVVLTVNVDCRKQTLQRYQKSENSRLLCTDCPESPRIRNLSLEECARKCSKSKKSCRAFYFDHINRKCHFLPFDRFSEGAKRERKPSCDLYEKKDYVRECIIGSGVNYKGRRSFTKTGITCQSWNMSVPHEHNFKPTRHKKSDLRQNFCRNPDNDPNGPWCFTELTETRHQDCGLPQCSDVECMKCNGETYRGPMDHTESGKECQRWDSQKPHKHTYQPHRHVGKGLDDNFCRNPNNDVRPWCYTMDKNTPWEYCNISVCDSDSDVEVEVTSSCFRGQGEGYRGTVNVTPAGVTCQRWDALSPHIHSYTPHNYKCKDLRENYCRNPDGSEIPWCFTTDAKVRKAFCTNIPRCESESSDSTECYEDNGESYRGNLSKTRSGIPCGLWSDHTFRRDTRSAKASAGLELNLCRNPDRDKHGPWCYTSNSSIPWDYCGLERCKSMSSDDHQMSGGPKPSCFIHKTTRIVGGMRVQRAEDGSWVVSIQKGNRHWCGGSLIREEWVLTDQQCFSTCVPDLSEYTVQVGLLHLNASAGTQALRIAHVVCGPEGSNLALLKLTTPAPLSEHVRTVQLPVAGCAVAEGTLCLMYGWGDTKGTGHEGSLKMVGLPIVSNKRCSQSHNGILPITETKICAGGKRDQGVCEKDYGGPLVCQEGESKVIVGVSINGRGCAVARRPAVFVNVAFYSEWIRKVFKYYSDMEISY
Protein: Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) (P53731)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, actin patch.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 1
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 5
- Proline-rich protein LAS17
- Actin
- Protein LDB17
- Guanine nucleotide-binding protein subunit beta
Sequence:
MLHLQPQNLLIQKTLNEAIEALRKGSPLTMDRIVSDFDYTTYHISNTAEDKSILLLSVKTKAWVSVSECQLDGSLTLLKFLADHYSSLGGVTIPSEVEPGYDYTLQITLAELVQESILQLSVLKTIILSFPFELAISKFIELSQQQPAPVEAEITGGEVAANGDNTLFTIKYRDEENIFIKPSNDRVTIIFETIFQDETDKIFGKVFLQEFVDARKRNRQIQSAPQVLYSHEPPLELKRLYQPPKVAEQSRRFITFVLFPRHFQTKELQFHSICQLTLFRNYFHYHIKCSKAYMHSRMRFRVDSFIKVLNRAKVDEDDENDELSAEGRQQARRTFTGRKIVY
Protein: Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit) (P07727)
Organism: Rattus norvegicus (Rat)
Function: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).
Subcellular location: Postsynaptic cell membrane {ECO:0000305|PubMed:6286620}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q64018}. Synapse {ECO:0000269|PubMed:6286620}. Perikaryon {ECO:0000250|UniProtKB:Q64018}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q64018}. Cell membrane {ECO:0000269|PubMed:11981023, ECO:0000269|PubMed:1716350, ECO:0000269|PubMed:2483325, ECO:0000269|PubMed:3037383}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}.
Interaction partners:
- Gephyrin
- Glycine receptor subunit beta
- Glycine--tRNA ligase
- Glycine receptor subunit alpha-2
- Sodium- and chloride-dependent glycine transporter 2
- Glutamate receptor ionotropic, NMDA 3A
- Vesicular inhibitory amino acid transporter
- Sodium- and chloride-dependent glycine transporter 1
- Leucine-rich glioma-inactivated protein 1
- Solute carrier family 12 member 5
Sequence:
MYSFNTLRFYLWETIVFFSLAASKEADAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQDDEGGEGRFNFSAYGMGPACLQAKDGISVKGANNNNTTNPAPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNK
Protein: Probable protein phosphatase 2C 4 (AtPP2C04) (EC 3.1.3.16) (Protein POLTERGEIST-LIKE 5) (Protein phosphatase 2C PLL5) (PP2C PLL5) (Q9LQN6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in leaf development regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 5-B
- Probable protein phosphatase 2C 5
- At5g65925
- Peter Pan-like protein
- Histone deacetylase complex subunit
- Protein phosphatase 2C 70
- Probable lysophospholipase BODYGUARD 2
- Protein SHI RELATED SEQUENCE 8
- Probable protein phosphatase 2C 49
Sequence:
MGNGVTKLSICFTGGGGERLRPKDISVLLPDPLDEGLGHSFCYVRPDPTLISSSKVHSEEDTTTTTFRTISGASVSANTATPLSTSLYDPYGHIDRAAAFESTTSFSSIPLQPIPKSSGPIVLGSGPIERGFLSGPIERGFMSGPLDRVGLFSGPLDKPNSDHHHQFQRSFSHGLALRVGSRKRSLVRILRRAISKTMSRGQNSIVAPIKSVKDSDNWGIRSEKSRNLHNENLTVNSLNFSSEVSLDDDVSLENQNLQWAQGKAGEDRVHVVVSEEHGWLFVGIYDGFNGPDAPDYLLSHLYPVVHRELKGLLWDDSNVESKSQDLERSNGDESCSNQEKDETCERWWRCEWDRESQDLDRRLKEQISRRSGSDRLTNHSEVLEALSQALRKTEEAYLDTADKMLDENPELALMGSCVLVMLMKGEDIYVMNVGDSRAVLGQKSEPDYWLAKIRQDLERINEETMMNDLEGCEGDQSSLVPNLSAFQLTVDHSTNIEEEVERIRNEHPDDVTAVTNERVKGSLKVTRAFGAGFLKQPKWNNALLEMFQIDYVGKSPYINCLPSLYHHRLGSKDRFLILSSDGLYQYFTNEEAVSEVELFITLQPEGDPAQHLVQELLFRAAKKAGMDFHELLEIPQGERRRYHDDVSIVVISLEGRMWKSCV
Protein: Large ribosomal subunit protein uL2m (54S ribosomal protein RML2, mitochondrial) (L2) (P32611)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24675956}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS5m
- Large ribosomal subunit protein uL16m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL22m
- Small ribosomal subunit protein bS18m
Sequence:
MLVLGSLRSALSCSSTASLISKRNPCYPYGILCRTLSQSVKLWQENTSKDDSSLNITPRLLKIIPNDTDIVTLEKQDELIKRRRKLSKEVTQMKRLKPVSPGLRWYRSPIYPYLYKGRPVRALTVVRKKHGGRNNSGKITVRHQGGGHRNRTRLIDFNRWEGGAQTVQRIEYDPGRSSHIALLKHNTTGELSYIIACDGLRPGDVVESFRRGIPQTLLNEMGGKVDPAILSVKTTQRGNCLPISMIPIGTIIHNVGITPVGPGKFCRSAGTYARVLAKLPEKKKAIVRLQSGEHRYVSLEAVATIGVVSNIDHQNRSLGKAGRSRWLGIRPTVRGVAMNKCDHPHGGGRGKSKSNKLSMSPWGQLAKGYKTRRGKNQNRMKVKDRPRGKDARL
Protein: Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain] (P51460)
Organism: Homo sapiens (Human)
Function: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Subcellular location: Secreted.
Interaction partners:
- Relaxin receptor 2
- Relaxin receptor 1
- Prorelaxin H1
- Prorelaxin H2
- Relaxin-3
- Insulin-like peptide INSL5
- Relaxin-3 receptor 1
- Early placenta insulin-like peptide
- Relaxin-3 receptor 2
- Muellerian-inhibiting factor
Sequence:
MDPRLPAWALVLLGPALVFALGPAPTPEMREKLCGHHFVRALVRVCGGPRWSTEARRPATGGDRELLQWLERRHLLHGLVADSNLTLGPGLQPLPQTSHHHRHHRAAATNPARYCCLSGCTQQDLLTLCPY
Protein: Metallothionein-like protein 3 (MT-3) (O22433)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of copper (Cu) and zinc (Zn). Plays a role in Cu homeostasis, specifically in the remobilization of Cu from senescing leaves. The mobilization of Cu from internal sources is important for seed development.
Interaction partners:
- Metallothionein-like protein 2A
- Late embryogenis abundant protein 41
Sequence:
MSSNCGSCDCADKTQCVKKGTSYTFDIVETQESYKEAMIMDVGAEENNANCKCKCGSSCSCVNCTCCPN
Protein: Transcription regulator PadR N-terminal domain-containing protein (A0A0H2UN55)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLYPILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWALYTDTINGIIEGSIRHDKN
Protein: CRISPR-associated protein Csy1 (Q02ML9)
Organism: Pseudomonas aeruginosa (strain UCBPP-PA14)
Function: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 and Cascade participate in CRISPR interference, the third stage of CRISPR immunity (Potential). Involved in crRNA production or stability. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.
Interaction partners:
Sequence:
MTSPLPTPTWQELRQFIESFIQERLQGKLDKLQPDEDDKRQTLLATHRREAWLADAARRVGQLQLVTHTLKPIHPDARGSNLHSLPQAPGQPGLAGSHELGDRLVSDVVGNAAALDVFKFLSLQYQGKNLLNWLTEDSAEALQALSDNAEQAREWRQAFIGITTVKGAPASHSLAKQLYFPLPGSGYHLLAPLFPTSLVHHVHALLREARFGDAAKAAREARSRQESWPHGFSEYPNLAIQKFGGTKPQNISQLNNERRGENWLLPSLPPNWQRQNVNAPMRHSSVFEHDFGRTPEVSRLTRTLQRFLAKTVHNNLAIRQRRAQLVAQICDEALQYAARLRELEPGWSATPGCQLHDAEQLWLDPLRAQTDETFLQRRLRGDWPAEVGNRFANWLNRAVSSDSQILGSPEAAQWSQELSKELTMFKEILEDERD
Protein: fructose-bisphosphatase (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase) (G5EAZ6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- ATP-dependent 6-phosphofructokinase
- Glucose-6-phosphate isomerase
- Transaldolase
- Fructose-bisphosphate aldolase
- Fructose-bisphosphate aldolase
- Fructose-bisphosphate aldolase
- Transaldolase
- Transketolase
- 6-phosphofructo-2-kinase domain-containing protein
- Phosphotransferase
Sequence:
MTTNSTGNGGAVGQENINTDIVTLSRFFTEEQTKVPEATGDFTLLCHALQFSFKSIAYYIRRASLINLTGLAGSSNTTGDDQKKLDVIGNDLFVSAMRTSGKCRILVSEEEEEAIIFDEHPNARYAVVCDPIDGSSNLDAGVSVGTIFGIFRLPDDILGPGKKVTAKDVLLPGTEMVAAGFTMYGASAQLVITMKNGGVNGFTLENSLGEFILTHPNMKLPPSRAIYSVNEGNSMYWDDWCNAYFDSLKRPGEGKKPYSARYIGSMVADAYRTLLYGGVFAYPADSKSPKGKLRILYECAPMAMVFENAGGKAVNSRMERLLSVQPESIHDKSGVFLGSRDEVQKVIDTYNKYKK
Protein: Probable exopolygalacturonase A (EC 3.2.1.67) (Galacturan 1,4-alpha-galacturonidase A) (Poly(1,4-alpha-D-galacturonide)galacturonohydrolase A) (A2QW66)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Function: Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MKLPILVTLFITLPALCVSSKTPSAPTISAYPKSPGNFKPASGRQNSTSNVCEVKPNQTDAAPGILAAAHTCNNGGTVFLPPGDFVVATALDLTFLNNIDFAIWGNITFKKDIDLWTTQAFQYTFQTASLFWRFGGNNVNIYGDGKGVIDGAGQYWWSAMAEDSSVMRPCLLGTDGLHHATISGLTMLNSPNWFNLIANSTDILISNMTMLVESEISDAPAKNTDGWDIYRSSNIVIQDSRIVNTDDCVSFKPNSTQIVIQNLDCTGSHGISVGSLGQYQGETDIVEDLYIYNISMTDASDVARIKVWPGVPADTSGSTSGGGLGRVRNVTYEHMQSENNDHIISVSQCYESKNQTMCDSYPSKLVIEDVLFKDFKGTTSKKYDPEIGELTCSSPDVCHNITVQDINVTPPSGDSPTFTCNNMGNSNLEDITCA
Protein: R-spondin-1 (Roof plate-specific spondin-1) (Q6DHR0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9Z132}.
Interaction partners:
- Leucine-rich repeat-containing G-protein coupled receptor 4
- E3 ubiquitin-protein ligase znrf3
- R-spondin-3
- R-spondin-2
- Protein Wnt-4a
- Forkhead box protein L2
- Noggin-3
- Noggin-2
- Noggin-1
- Catenin beta-1
Sequence:
MHLGLLALALVFFSSMGHADNLKASKARRQRRISTEVPPSCSNGCEHCSEYNGCLKCRPRLFILLERNDIRQIGICLAACPVGYYGIRNRDMNKCTQCKIENCEACFSRNFCTKCKEGLYSHRGRCFSSCPEGFTVNGTMECVVQCDLSEWSPWGPCMKKNKTCGFKKGNQTRTREPLQVPSPATSTGAAPASGCVPEIQTQRCTVQKKIPCKGENKKNQQNRGENSKNRGRDSKERGGNKKRKNTNRSTTVPTITTSMVT
Protein: Paired box 10 (I3IT91)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Reticulocalbin 1, EF-hand calcium-binding domain
Sequence:
MYDNLTMLNLQNSSNWSGPNNWYHPADTITPQHGTDGCVEDLNVQMAGAGEGVVQGERDEVDDSQLHLQLKRKLQRNRTSFTQEQIDALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRSGSSSSCSQTHTPLSTSFNSPVYHSHHSNSSGSMHSRSDSSLSGYSSLSVFSSMQSLPSQSTPTYSCMLPPSPSALPPLSRKFDSSYTSPHLPPPPTASANTGFFAGVSAAGQTAVQGGDQELGQGLSQYWTRLQ
Protein: FAM63A-like protein (DUF544) (Q8LE63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MATASSSESPSEETQTNQEAMQQQDLPKETTTEEEILYKTKSIQFLGRTTPIILQNENGPCPLLAICNVLLLRNNLNLNPDCYEVSQERLMSLVVDRLIDSNSKVNNKDEGYIENQQQNIADAIDLLPRLTTGIDVNIKFRRIDDFEFTPECAIFDLLDIPLYHGWIVDPQDVEAANAIGSKSYNALMGELVALETQNVEAQGDQNPGEDSVDFAAATTAVLGVPSPCLSKTRSFDDSPPAAAELRRMRKGDLEEETELLQALQLSQGQGNDPTPNTNGDSTNQDSAFTFSDASPTSTHITNISQLDQFKTDDDKASENDGNMIKVGKFPTTITTKSEDLNHDQLSSKQSGGETACDVENVSSSKEAIVDVTSSEALSVDKGNLESAKSESSSESVLKSDAASIDPDLSCRSQHDDAPNAFIPPVSTDEPMYEGEECVNTVPPVCADKEPVYEGESLLGKRVEKDVGDCSSEGRATDGLTAEEGELIRNFMKNSASQLTFCGLFRLQEGLKERELCVFFRNNHFCTMFKYEGELYLLATDQGYLNQPDLVWEKLNEVNGDTAFMTATFKDFTIDSSTGGASGTWDERNAVTNTADYLASINNVADAGIDVNSDLQLAIALQQQEFEDQSPRSNPTPQPTSVAASRLVTGPQVPRSSHRPSSAASSRHDGKSPKDKDSKCRIM
Protein: Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) (O75478)
Organism: Homo sapiens (Human)
Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Subcellular location: Nucleus {ECO:0000269|PubMed:22644376}. Chromosome {ECO:0000250|UniProtKB:Q8CHV6}.
Interaction partners:
- Transcription initiation protein SPT3 homolog
- Transcriptional adapter 3
- Histone acetyltransferase KAT2A
- SAGA-associated factor 29
- Histone acetyltransferase KAT2B
- Transformation/transcription domain-associated protein
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 10
- Transcription factor SPT20 homolog
Sequence:
MDRLGPFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSPSIPMASNSGRRSAPPLNLTGLPGTEKLNEKEKELCQMVRLVPGAYLEYKSALLNECNKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYITKG
Protein: Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (Q563Y0)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Interaction partners:
Sequence:
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE