wanglab/gogpt-training-data huggingface dataset:
Protein: Serine-arginine repetitive matrix 2/3/4, isoform A (Serine-arginine repetitive matrix 2/3/4, isoform G) (Q7YZ99)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MYNGIGLTTPRGSGTNGHVQRNWACVRPGKKDKDYRAEDDTKKLDAQLNRPPNKEILDHDRKRKIEVKCLELEDILEKQGRTPEEIKSQVDSFRQKLMGQGKTDLAKDEFGRVAARDTHQIAEAQQQKNARLREAFNISEYFVEGSSFDGDRKAKEDLAKSVALQKELDAQRESLAAAAAAAAAGKDKETGKRYALVRTPSRERDRDAGDAAANGDERDHVSKTDKKKRKKRARESSASPERKKKKKSKKHKKESKSKKKRSRKRKHSESGRDSDRDSDEEDDSSEEERRESKNVRKKAKKDKKKRDKKLKKKSRARASSSDSERTNSPSRKENKSDRSRGAKASKSDEKAPQQENVMRSRSRERKDTRSSRPLEASIDSRQRKPRERSAATPPRKEPERHRERSKDRQRSKEKHRSRDRLRSRERQRSRERQRSRERQRSKERQRSKERQRSIERQRSKERQRSKERQRSRSKDALRCKEKPQCNEKERSRERRRSKSKDRQRSKEKHRPKDEQQSVDKRRDRSTDRSKENQRSNERQRSKERQRSKERERSKDRQRSRERRRSKEGQLSKDRQGLKERQRSNERKRSKERQPSKEKQRSRERQRSREPLQSKDRQRSKERQRSRERPAKEARPTRSPRERSSKSRDDRRHRSPTNASRKQKDDTKLSRNARFKSPAHSPEAPPKKSVPTPAFNPFKAAEDTVNDILGTKSVMVALEQTKRQRAASSSSSDSDSSGSSSTSSRTPSPKPTPRKQKKRSKTPELKEVKKEISPRKESRVSVKREQSNSPQKSKSKSKVDESSPKRTSRRSRSISSELRYSPAERHPERYHDIVQDKKRPSKVREAHSTKPAPVVRLRAQSDDGSDAETGVDGAALEEFQQSRREREEQQELRMLEQLKSGIAAKAKQKIKIMEKDPAKEGSEPLVAALADSSLVDAIVSKVSTATVAAAESAARRSRSRERRSRSKRRTSTSHHRHDSSSESRSRYSSSSSRSGSHSSRSGSHSSRTSCSTNSSSGSSSSGSGSGSSQSGSRSPSIPRRRGSPSFLDRRRITSRRSPRSTRR
Protein: Alpha-N-acetylglucosaminidase (N-acetyl-glucosaminidase) (O88325)
Organism: Mus musculus (Mouse)
Interaction partners:
- Heparan-alpha-glucosaminide N-acetyltransferase
- Heparan N-sulfatase)
- N-acetylglucosamine-6-sulfatase
- Alpha-L-iduronidase
Sequence:
MEAAGLAVILGFLLLAGGSVGDEAREAKAVRELVVRLLGPGPAANFLVSVERALADESGLDTYSLSGGGGVPVLVRGSTGVAAAAGLHRYLRDFCGCQVAWSSAQLHLPWPLPAVPDGLTETTPNRYRYYQNVCTHSYSFVWWDWARWEQEIDWMALNGINLALAWNGQEAIWQRVYLALGLTQSEIDTYFTGPAFLAWGRMGNLHTWDGPLPRSWHLSQVYLQHRILDRMRSFGMIPVLPAFAGHVPKAITRVFPQVNVIKLGSWGHFNCSYSCSFLLAPGDPMFPLIGNLFLRELTKEFGTDHIYGADTFNEMQPPFSDPSYLAATTAAVYEAMVTVDPDAVWLLQGWLFQHQPQFWGPSQIRAVLEAVPRGRLLVLDLFAESHPVYMHTASFHGQPFIWCMLHNFGGNHGLFGALEDVNRGPQAARLFPNSTMVGTGIAPEGIGQNEVVYALMAELGWRKDPVPDLMAWVSSFAIRRYGVSQPDAVAAWKLLLRSVYNCSGEACSGHNRSPLVKRPSLQMSTAVWYNRSDVFEAWRLLLTAAPNLTTSPAFRYDLLDVTRQAVQELVSLCYEEARTAYLKQELDLLLRAGGLLVYKLLPTLDELLASSSHFLLGTWLDQARKAAVSEAEAQFYEQNSRYQITLWGPEGNILDYANKQLAGLVADYYQPRWCLFLGTLAHSLARGVPFQQHEFEKNVFPLEQAFVYNKKRYPSQPRGDTVDLSKKIFLKYHPQPDSL
Protein: Cytochrome P450 72A552 (EC 1.14.14.-) (A0A481NR20)
Organism: Barbarea vulgaris (Yellow rocket) (Erysimum barbarea)
Function: Catalyzes the oxidation of oleanolate at the C-23 position to form hederagenin.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEISVASVTVSVVIAVVTWWVWRTLKWVWFQPKMLESYLRRQGLSGTPYTPLVGDLKRNSKMLTEAISKPIRLNDDITQRVVPYPLQMLKTYGRTHFTWLGPIPAITIMDPELIKEVFNRVYDFQKARLFPLARLIATGLVRYDGDKWAKHRKIINPAFHLEKLKNMVPAFHQCCSEVVGAWDKLVSDKRSSCEVDVWPGLVSMTADMISRTAFGSSYKEGQRIFELQEEIKELLIQSLGKAFIPGYHYLPTKGNRRMKAADREIKVILRGIVNKRLRAREAGEAPSEDLLGILLESNLGQAKGNGMSIEDVMEECKLFYLAGQETTSVLLVWTMVMLSQHQDWQARAREEVKQVFGDKEPNTEGLNQLKVMTMILYEVLRLYPPVTQLPRAIHKEMKLGDMTLPAGVHINLPIMLVQRDTELWGNDAAEFKPERFKDGLSKAAKNQVSFFSFAWGPRICIGQNFALMEAKMAMALILQRFSLELSPSYVHAPYSVITLHPQFGAHLILHKLY
Protein: At3g52060 (Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein) (Q9SUZ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- RING-type E3 ubiquitin transferase
- Polypyrimidine tract-binding protein homolog 3
- PLASMODESMATA CALLOSE-BINDING PROTEIN 1
- Allergen-like protein BRSn20
Sequence:
MFSSSTLVYSLSLFLSLSLLFFLFILSPHILLSSSTLISTADDLDDLSLFHRAVVSSSTNNNRRLISLSPNPPPKIAFLFLTNSDLTFLPLWESFFQGHQDLYNVYIHADPTSSVSPLLDSSSINAKFIPARRTARASPTLISAERRLLANAILDDPNNLYFALISQHCIPLHSFSYIHNHLFSDHHQQSFIEILSDEPFLLKRYNARGDDAMLPEIQYQDFRVGSQFFVLAKRHALMVIKERKLWRKFKLPCLDVESCYPEEHYFPTLLSLEDPQGCSHFTLTRVNWTGSVGGHPHTYDASEISPQLIHSLRRSNSSLDYFFARKFTPESLQPLMEIADAVIFRD
Protein: Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (EC 2.4.1.-) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6) (Q9WVK5)
Organism: Mus musculus (Mouse)
Function: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15291}; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack. {ECO:0000250|UniProtKB:P15291}.
Interaction partners:
- Ceramide glucosyltransferase
- Lactosylceramide 4-alpha-galactosyltransferase
- Lysosomal acid glucosylceramidase
- Non-lysosomal glucosylceramidase
- Lactosylceramide alpha-2,3-sialyltransferase
- Beta-galactosidase
- Beta-1,4 N-acetylgalactosaminyltransferase 1
- Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
- Alpha-galactosidase A
- Alpha-1,3-galactosyltransferase 2
Sequence:
MSALKRMMRVSNRSLIAFIFFFSLSTSCLYFIYVAPGIANTYLFMVQARGIMLRENVKTIGHMIRLYTNKNTTLNGTDYPEGNNTSDYLVQTTTYLPQNFTYLPHLPCPEKLPYMRGFLSVNVSEISFDEVHQLFSKDSEIGPGGHWRPKDCKPRWKVAVLIPFRNRHEHLPIFFLHLIPMLQKQRLEFAFYVIEQTGTQPFNRAMLFNVGFKEAMKDRAWDCVIFHDVDHLPENDRNYYGCGEMPRHFAAKLDKYMYILPYKEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVHYAGYNVTRPEGDLGKYISIPHHHRGEVQFLGRYKLLRYSKERQYIDGLNNLLYTPKILVDRLYTNISVNLMPELAPIEDY
Protein: bZIP transcription factor 39 (OsbZIP39) (Q6AU90)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor involved in endoplasmic reticulum (ER) stress response. Acts as ER stress sensor and activates the transcription factor BZIP50 and the chaperone BIP1.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22084314}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:22084314}. Note=The bZIP domain is translocated into the nucleus in response to ER stress. {ECO:0000269|PubMed:22084314}.
Interaction partners:
- Kinetochore protein NDC80
- Kinetochore protein SPC25
- Kinetochore protein SPC25
- bZIP transcription factor RISBZ1
- bZIP transcription factor RISBZ2
- Os12g0601800 protein
- bZIP transcription factor RISBZ3
- bZIP transcription factor RISBZ5
- bZIP transcription factor RISBZ4
- Os08g0163100 protein
Sequence:
MAEPALLDPTAAFDLRLYPAHLFDHELPLAGGGGGDDDDDLPLDGLEFDLPGDFSVEDFLLRSPERDDSGEGSAAGSGPTASPSSSPTTSASNSAVANGSGGEVKHEESDEGRSGGGDPKWSLKRKQASPGPSSDAAKCRRSGDGDVSPSASASRTAVDSDEGGTVCEEEEDERRAARLMRNRESAQLSRQRKKRYVEELEEKVKSMHSVINDLNSRISFVVAENATLRQQLSGGSVNCPPPGVYPPAPIPGMHFPWMPGYAMRPPGSHVPLVPIPRLKPQQPVPSSKVVKKPESKKTVENKSKSKTKTKKVASVSLLGLLLIMLVFGAFIPGFNHNFGMCGQSDNAMFRNFGQSHARVLSVSSQDKSSLNNSDMIGVDVGKMTGNTDGPGKKHQPAHNSSEILPALLYVPRNGKHVKINGNLIIHSVLASEKAVAHKASKDDSDQSARDHKETSVAIARYLSLPGKDVNRQETSSADGPLPQWFREGMEGPILNSGMCSEVFQFDISTASSNPGGIIPASPVVNSSSVNATEKIPAHSAAYHGKLKNRRVMYNEAIPLTGKTANNTEPFNRTSESSSKLPDSKPASSVVVSVLADPREAGNGDGDPRVSPKPLSKIFVVVLVDGVRYVTYSCTLPFKSSSPHLVN
Protein: Hepatocyte growth factor-like 1 (Hepatocyte growth factor-like protein precursor) (Q90ZN6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MFMLFFLTALLLRLDSVDGYRSALNDFQRSEGRELVLKSWNVNRLTELPRVTLEDCAKRCTESPECRAFNYEFRPSLVCKHLPWVGDGDNADVKRNVNCDLYEMKVYVRKCIVGKGEDYRGKVSTTTSGRTCQQWWSKFPHDHRWTPSATNGLELNYCRNPDGDRIGPWCYTTDPERRYESCNIPQCKDEVCITCNGEDYRGQVDHTISGKECQRWDQQFPHQHIYQPEKYPDKSLDDNYCRNPDASPVPWCYTTDPTMERESCDISKCPEFPKRRLRSSYTTNCFRGRGEDYRGKVNETTSGIPCQRWDAQKPHEHPFFPKTYECKGLEENYCRNPDGSEAPWCFTSLPEMRTALCLQIKRCADDIEAEDCYNEIGKNYRGVVRKTRKGILCQKWSINTPHKTKINPKTHPEANLTDNYCRNPDGDHHGPWCYTSDPKTEFDYCAIKQCAGEKVPIIGPTTEVEFNECGKREDRLRSRLRIVGGTPGNSPWTVSLRDRKGNHFCGGSLVSSEWVISTKQCFSSCYVDLTGYTAMMGTLFRDPKEGEPDLQRISLTKIVCGPSESHLVMLQLETPAQFNERVSQICLPPERYIVPDGTICEIAGWGETKGKGDETVLNVAQMPVLSNKDCNQYFKGRVRENEMCTMAFQAGVGACERDYGGPLACQNSDCWVLEGVIIPMRRCGHAGQPNIFIRVSVYVDWIKKVMEMT
Protein: Segregation and condensation protein A (P35154)
Organism: Bacillus subtilis (strain 168)
Function: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12897137}. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Interaction partners:
- Segregation and condensation protein B
- Chromosome partition protein Smc
- Stage 0 sporulation protein J
- Uncharacterized protein YpuI
- SPbeta prophage-derived uncharacterized transglycosylase YomI
- Ribosomal large subunit pseudouridine synthase B
- Protein RibT
- Cytidylate kinase
- Uncharacterized protein YpuF
- Sporulation initiation inhibitor protein Soj
Sequence:
MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLYVHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLIEYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKVLKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFLAVLELMKNQLVLIEQEHNFSDIYITGSESIHGA
Protein: Trehalose synthase/amylase TreS (EC 3.2.1.1) (EC 5.4.99.16) (Maltose alpha-D-glucosyltransferase) (MTase) (P9WQ19)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the reversible interconversion of maltose and trehalose by transglucosylation. Also displays amylase activity, catalyzing the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in glycogen and maltooligosaccharides such as maltoheptaose, to produce maltose which then can be converted to trehalose. TreS plays a key role in the utilization of trehalose for the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P). Might also function as a sensor and/or regulator of trehalose levels within the cell. Thus, when trehalose levels in the cell become dangerously low, TreS could expedite the conversion of glycogen to maltose via its amylase activity and then convert the maltose to trehalose; but this enzyme also could expedite or promote the conversion of trehalose to glycogen when cytoplasmic trehalose levels become too high.
Interaction partners:
- Maltokinase
- Putative maltooligosyl trehalose synthase
- 1,4-alpha-glucan branching enzyme GlgB
- Uncharacterized glycosyl hydrolase Rv2006
- Trehalose-phosphate phosphatase
- Glycogen operon protein GlgX homolog
- Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
- Malto-oligosyltrehalose trehalohydrolase
- Trehalase
- Glycogen phosphorylase
Sequence:
MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWFKHAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTSESHPWFQESRRDPDGPYGDYYVWSDTSERYTDARIIFVDTEESNWSFDPVRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLGIDGFRLDAVPYLFEREGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAEANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFMAVRRESRFPISEIIAQTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYGYQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLAYVRQVAGDDGDTVLCVNNLSRFPQPIELDLQQWTNYTPVELTGHVEFPRIGQVPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL
Protein: C2 domain-containing protein (B2D6N9)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MTRTVTHAIPKWRQNILYTIKNQPLEKLAAKVLTLRLVRPTALGESSVGEFSCYLSEVIHSPDRSVIAKWVALGFPGMDDEEPDDIAYENCGFLKVTLSVYRIDESPPTLIDDDGKEQIWSGAHLIDYTLKIRVFSVEQLIRQMINERKIKKKQRFYVMVQCGAHKTETTMESAFLDEDANIASVKFEQEIYLPIQWPTVISEIIFSLFDKKGRGKTCIGKATLPMKMIYEPGETGYLPTFGPAFLNVFDCERVTRFSIFSRKMRGSQQDGSRFVGRLFIAIDCVEYMEKANAQIMHLDHSPIMEAESICKNLEWYNCFCSMSGLNMINPQFASDPVCIMMSIGSFGSTSNEFRSCNSSTLPAEPNWDGCKYFTMPWGNLRPVAEVNAPWEVIEHRIEMSNVLMKMTNMLDTMIWEVRRIGNKAIDHVSSVGMEALECLEQQIDSASKYLGRINPVSSNALDRHILDYRKEKILKLREHFEKEAFSIDYSDGEVDAKLLRMLLKIRSMTLELAEDVQMTIPPVLIKMMSHGKLIGFAKIPISEIFQSDDEAQSGEWCGRTRAINIQWPTLVDQRNRKREHVAVLHAKMWFGRTDQLTKWKEHVQPADIRRFMEMYEVQTKGLALKWKDEADIYDGKWEKTNEVPLENGWNAVGHWIVMNTRHMFVPKLGQHTVHDKAFEIQKRTEDGTWKHFKYTDCYADELKPKDLDKHAKGWEVGSWAQDKFRNNGDEKGWVYSTNGVFFGSGVLTDREEKVHHNFRKRCIKRPRKHEGYNKELEDFEHFRTTMGNENWEYSPSKKEGPYHDLEDRTDRIRRRRYVREVENKDPDSEDPRFRVYEYQMQTGKWQLRCYIMWGNDLLPVVKNSSRAFVRISFAQYSKQTLLVDNSQNPIWNETVMFKSVLIAGGTRDIMKYPPVVSVEVVGECSNNEEANLGHFETKPNVICGNTDVRGTPQWFPLKFSNGRTRGAVLACFELYSEEDKDLIPLEPKCKHNYKERSEIPTEFRPQFDKFHVQFLCWGVRNLKKHKLLAVRRPFVGLTIGDQEFTLQPLKDVRRDPNFPEPMIVFGEVILPSALELSPPLIINLFDARAFNRQPLVGSCLVSDLHKYVSHIVPKVKSDHAERWEQLDLVITEEFDQIIRMVRVPTLTTDPMVPLDWWSRYYASMSQFHRSPGYPESGMEYVRIFRRPLEQMNGYNNFSDFLDTFPFVKSMKGDFDDPEEKEKAGELKCRLLISKLKKGKPPAAINTVVDFVGPTRCLVRVYIIEANGLISNARKGRVDSYVKLHCGKQNVNLKKNYRSECCDPIFGERVDMTVTIPLEKDLKITVMGKRRILSDQEIGSTTIDLENRLLTKWRATGGLSGQFTVQGELQWRDQMTPMEILKSYCYKMMLSVPKIESRQTERGEEKGITIEKITFWFSEVLHVFENEEIAMLNSQRQKAGKENFSDGSDQQNEDVSDGSWDEEDLEREKEKLKWEKHRSKGKPLKKVTTEKAETADGELRKKAKMRIMGSQLQTIALFILRQMNLVPEHVESRPLFSDKGGRTQKGELRMFVDIFPMEYGAIPAPFNIAPRKPINYQLRIAVMDVRGAIPVKRSFAEPVSDLYVKAFINGMTKGHKTDTHFRVLDGTGEFNWRFLLNFDYNPWEKKVVAYTKNRFFCKPVEELVDPILVIELWDKNKFRKDRLLGDIELDLLDFIEGIGSPSDVGVYSTKKRQRGVKCPKCCTRRGCLCKCCIFCFETKCLCGKRKVKKKPFPKPVLFVEPEGYDDTVNIFESRNLYGWWPMLTEEYPHEEPQNAKKKNDDVGKDPKWIMGLVEMDMLLLTKQEADQEPAGKKRSEPNHSPFLEKPDRKSWANSWLVSRIKPCIKYFWHYYGLQILLWLIIIVILILTIFVLLHTWPTILAEIIKAIF
Protein: ATPase family AAA domain containing 2B (H7BYF1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XEDENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPALLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIEEDRRKFFQELILNQASMAPPRRKHAALCAMEVLPLALPSPPRQLSESEKSRMEDQEENTLRELRLFLRDVTKRLATDKRFNIFSKPVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTSEQINPHSTGARKTETRVEEAFRHKQRNPMDVWHNSANKCAFRVRRKSRRRSQWGKGIIKKRKVNNLKKDEEDTKFADYENHTEDRKLLENGEFEVSTDCHEENGEETGDLSMTNDESSCDIMDLDQGQRLNNGAGTKENFASTEEESSNESLLVNSSSSLNPEQTSRKETFLKGNCLNGEASTDSFEGIPVLECQNGKLEVVSFCDSGDKCSSEQKILLEDQSKEKPETSTENHGDDLEKLEALECSNNEKLEPGSDVEVKDAELDKEGASKVKKYRKLILEQAKTTSLELVPEEPSEPVPPLIVDRERLKKLLDLLVDKSNNLAVDQLERLYSLLSQCIYRHRKDYDKSQLVEEMERTVHMFETFL
Protein: Growth factor receptor-bound protein 14 (GRB14 adapter protein) (O88900)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14449}. Endosome membrane {ECO:0000250|UniProtKB:Q14449}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14449}. Note=Upon insulin stimulation, translocates to the plasma membrane. {ECO:0000250|UniProtKB:Q14449}.
Interaction partners:
- Insulin receptor
- Fibroblast growth factor receptor 1
- Cyclic nucleotide-gated channel alpha-1
Sequence:
MTTSLQDGQSAAGRAGAQDSPLAVQVCRVAQGKGDAQDPAQVPGLHALSPASDATRRGAMDRRKAKDLEVQETPSIPNPFPELCCSPLTSVLSAGLFPRSNSRKKQVIKVYSEDETSRALEVPSDVTARDVCQLLILKNHYVDDNSWTLFEHLSHTGVERTVEDHELLTEVLSHWVMEEDNKLYLRKNYAKYEFFKNPMYFFPEHMVSFATEMNGDRSLTQIPQVFLSSNTYPEIHGFLHAKEQGKKSWKKAYFFLRRSGLYFSTKGTSKEPRHLQFFSEFSTSNVYMSLAGKKKHGAPTPYGFCFKPTKAGGPRDLKMLCAEEDQSRMCWVTAIRLLKYGMQLYQNYMHPSQARSACSSQSVSPMRSVSENSLVAMDFSGQKTRVIDNPTEALSVAVEEGLAWRKKGCLRLGNHGSPTAPSQSSAVNMALHRSQPWFHHRISRDEAQQLITRQGPVDGVFLVRDSQSNPRTFVLSMSHGQKIKHFQIIPVEDDGEVFHTLDDGHTKFTDLIQLVEFYQLNKGVLPCKLKHYCARMAV
Protein: Ionotropic receptor 31a, isoform D (Q8IPB8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MNLLISMFILILAAGEGEIIPSMEESVVTNFVKSLVKTKQAIVFSCLFKDFKEISLALMRINQFVSVVNLNQSYSLTSILTRENYARTSVMVNARCSGSSELLFEASENRYFNKTYQWFLWGVDLEVQSLFPLNLNYVGPNAQITYVNETADGYAYWDIHSKGRHLKSNLEINLIATLINDTLNIARDIFHLQSIDFRGQFNGLTLRGASVIDKEDIISNEQIESILSRPTKDAGVAAFIKYHYELLGLLRERFNFTVNFRNSRGWAGRLGNTTFRLGLLGIVMRNEADIAASGAFNRINRFAEFDTIHQSWKFETAFLYRYTSDLDTHGKSGNFLSPFSDRVWLFCLLTLGAFSIIWVLFEIIDYKILRIRVNSQKLEHLNQKSSVICIKTTCIERILQTFGACCQQGLDPNPVDRSVRFLVMTLFLFSLVMYNYYTSSVVGGLLSSSDQGPSTVDEITASPLKISFEDIGYYKVLFRESQNRSITRLIEKKLSSSRSLNELPIFSHIEDAVPYLKAGGFAFHCEVVDAYPVISEYFDANEICDLREVSGLMEVEILNWILHKNSQYTEIFKTAMCNAQEKGFVERILRRRQIKKPACQSLYTVYPVSLSGVLPGFVILICKSINKFS
Protein: Homeobox protein EMX1 (Empty spiracles homolog 1) (Empty spiracles-like protein 1) (Q804S6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Forkhead box protein G1
Sequence:
MFSATGKRCFTIESLVAKESPITLEDPIRPTALSYSAPADSFLNGYQSPAGRALYPNPELVFSETVNHAPLSMHPHQLGSAPLQHPHFFGTQHREPLNFYPWVLRNRFFGHRFQGNDVSQDTLLLHGPFARKPKRIRTAFSPSQLLRLERAFEKNHYVVGAERKQLANSLSLSETQVKVWFQNRRTKYKRQKLEEEGPECTQKKKGNHHINRWRIATKQTGSEDIDVMSDA
Protein: Increased DNA methylation 2 (Alpha-crystallin domain-containing protein 39.4) (AtAcd39.4) (Protein ROS5) (Repressor of silencing 5) (Q8RWL4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Prevents DNA hypermethylation and transcriptional silencing of transgenes and of some endogenous genes. May act as a molecular chaperone of IDM1, regulating its H3K18 acetylation activity.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:24920332, ECO:0000269|PubMed:25002145, ECO:0000269|PubMed:25593350}. Note=Colocalizes with IDM1 within nucleoplasmic and nucleolar foci. {ECO:0000269|PubMed:24920332, ECO:0000269|PubMed:25002145}.
Interaction partners:
- Increased DNA methylation 1
- Methyl-CpG-binding domain-containing protein 7
- Increased DNA methylation 3
- Protein REPRESSOR OF SILENCING 3
- Methyl-CpG-binding domain-containing protein 6
- DNA glycosylase/AP lyase ROS1
- DEMETER-like protein 3
- DEMETER-like protein 2
- Berberine bridge enzyme-like 5
- Protein IDA-LIKE 1
Sequence:
MSDTMPEIVSPLVAENSQEQEESVLISLDIEEDKLFLLHFIIGTYFGPDLRKQHHRPKQSAFQIQALKNVVVDELSGSLMKRAELERVYYHIIRNVDPSLVMKPKKLREYFNAKRNDSNRDYPLFVDLFPRKLHPETHVRHKFKFIRSIVFINDPDTSCMREECVARFKRLTGLDSFALSLSVDVTKSNGVVAANEVKVEIDESVEPVKEDNAGTCTSGEESDVAAKPEVKSEAHGGLMVGLMDIGECDDAYLFRVSLPGVKRDERYFSCEVEDNGKVLVRGVTTTGGKRVKRYSHVFEMQTRSLCPPGNFSVSFRLPGPVHPHEFSGNFGTDGILEGVVMKNLQKQTV
Protein: RE02556p (Q5U159)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSEADLKNLSQNSDGDQELLLHQTTQSLLMASSIMFVGNQGGPGGSAGGVAPPGPVSLPLPLSINMPHHHVHAMPYNVDELLRENNALHAKIKELSLERDRLLCEVSNLRLELDMSELKRLPVDLDDNFPQKRLERSGSTQYELAGAQQPGSANASTCTGSGSVGGYVYLQNHYAPGAHSSSAAINYPAQQHPQMVYQIQQYPTCHQQQQQQHLQQQQHLHQTGAGHYMQVTATGGGQYHHHHMLHGHGHHAHHHGGAVVIAGSGVGTGLGSGATSVIMQHQQQQQQQQNMHKKNSIRNGGDVLKRTRAQSAYELSQDLLEKQIELLERKYGGVRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKRLSRRMVVTASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAGPAGAASPGLSRTPPTRSLSMRERRQLDCSPIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPPSLLRTNGLCKTAENGSLTSVQSSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALNSSQQFSTHSADSAGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPDVNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAENRDSGVADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNEKPQRRGSVGSLDSGMSISFQSTTTSSASRENAAAIAAAANAAAAAKMRFNMPPTAAIATPSNVYAAPGMQAYTHANFVQQSQAAYMLQQQQMLQQQAQMQAQAQAQAQAQAQAQAQAQAQAQAQPLTGRIPGRERKASRTDENGRSTEV
Protein: Mitochondrial import inner membrane translocase subunit Tim10 (P62072)
Organism: Homo sapiens (Human)
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Intermembrane side {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim10 B
- Mitochondrial import inner membrane translocase subunit Tim13
- Mitochondrial import inner membrane translocase subunit Tim8 A
- Mitochondrial import inner membrane translocase subunit Tim9
- Mitochondrial import inner membrane translocase subunit Tim22
- Mitochondrial intermembrane space import and assembly protein 40
- Mitochondrial import inner membrane translocase subunit Tim29
- Mitochondrial import inner membrane translocase subunit Tim17-A
- Acylglycerol kinase, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim8 B
Sequence:
MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA
Protein: 11 kDa protein (Membrane protein US9) (Tegument protein US9) (A0A142I9X8)
Organism: Suid herpesvirus 1 (SuHV-1) (Pseudorabies virus)
Interaction partners:
Sequence:
MPTAAPADMDTFDPSAPVPTSVSNPAADVLLAPKGPRSPLRPQDDSDCYYSESDNETPSEFLRRVGRRQAARRRRRRCLMGVAISAAALVICSLSALIGGIIARHV
Protein: ADP-ribosylation factor GTPase-activating protein AGD10 (ARF GAP AGD10) (Protein ARF-GAP DOMAIN 10) (AtAGD10) (Protein MATERNAL EFFECT EMBRYO ARREST 28) (Protein ROOT AND POLLEN ARFGAP) (O82171)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTPase-activating protein (GAP) for ADP ribosylation factor (ARF). Activates ARF1 and ARF2. Required for female gametophyte development. Involved in root hair and pollen tube growth.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:16731582}.
Interaction partners:
- Coatomer subunit gamma
- Coatomer subunit beta-1
- Coatomer subunit beta-2
- Structural molecule
- Coatomer subunit delta
- Coatomer subunit alpha-2
- Coatomer subunit alpha-1
- ADP-ribosylation factor GTPase-activating protein AGD7
- Coatomer subunit beta'-2
- Coatomer subunit beta'-1
Sequence:
MASENLNDKISVFKKLKAKSDNKICFDCNAKNPTWASVTYGIFLCIDCSAVHRSLGVHISFVRSTNLDSWSSEQLKMMIYGGNNRAQVFFKQYGWSDGGKTEAKYTSRAADLYKQILAKEVAKSKAEEELDLPPSPPDSTQVPNGLSSIKTSEALKESNTLKQQEKPDVVPVSPRISRSVKKPLGAKKTGKTGGLGARKLTTKSSGTLYDQKPEESVIIQATSPVSAKSARSSFSSRFDYADNVQNREDYMSPQVVSHVAPPKSSGFFEEELEMNGGRFQKKPITSSSKLQIQETDEARKKFTNAKSISSAQYFGNDNNSADLEAKSSLKKFSGSSAISSADLFGDGDGDFPLDLTAGDLLNRLSLQAQQDISSLKNMAEETKKKLGSVASSLWV
Protein: Alpha/beta-Hydrolases superfamily protein (At2g32520) (Putative carboxymethylenebutenolidase) (O80889)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MADSAFRKIQIQRDDTTFDAYVVGKDDAPGIVVIQEWWGVDFEIKNHAIKISQLEPGFKALIPDLYRGKVGLDTAEAQHLMDGLDWPGAIKDIRASVNWLKSNGSKKVGVTGMCMGGALAIASSVLVPEVDAVVGFYGTPSSELADPAQAKAPIQAHFGELDNFVGFSDVTAAKNLEEKLKASGVAHEVHIYPGNGHAFLNRSPEGVSRRKSMGLSDEDEAAVELAWSRFTSWMKQYLA