wanglab/gogpt-training-data huggingface dataset:
Protein: Pre T-cell antigen receptor alpha (pT-alpha) (pTa) (gp33) (pT-alpha-TCR) (P0C6B2)
Organism: Mus musculus (Mouse)
Function: The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. Isoform 1 acts to retain most TCRB intracellularly, while isoform 2 permits higher levels of cell surface TCRB expression and facilitates signaling from the CD3-TCRB complex.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q6ISU1}.
Interaction partners:
- DNA-binding protein Ikaros
- T-cell surface glycoprotein CD3 epsilon chain
- Interleukin-7 receptor subunit alpha
Sequence:
MARTWLLLLLGVRCQALPSGIAGTPFPSLAPPITLLVDGRQHMLVVCLVLDAAPPGLDNPVWFSAGNGSALDAFTYGPSLAPDGTWTSLAQLSLPSEELEAWEPLVCHTRPGAGGQNRSTHPLQLSGESSTARSCFPEPLGGTQRQVLWLSLLRLLLFKLLLLDVLLTCSHLRLHVLAGQHLQPPPSRKSLPPTHRIWT
Protein: Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase) (P48775)
Organism: Homo sapiens (Human)
Function: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Interaction partners:
- Kynureninase
- Indoleamine 2,3-dioxygenase 2
- Indoleamine 2,3-dioxygenase 1
- Kynurenine formamidase
- Tryptophan 5-hydroxylase 1
- Tryptophan 5-hydroxylase 2
- Aromatic-L-amino-acid decarboxylase
- L-amino-acid oxidase
- Tyrosine aminotransferase
- Kynurenine 3-monooxygenase
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
Protein: Probable conserved integral membrane protein (O53668)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
Sequence:
MAKTSHRVSSADGMSKRILRLIIAQSGFYSAALQLGNVSIVLPFVVAELDAELWIAALIFPAFTAGGAIGNVVAPPAVAAVPRRHRLFIIVSCLAVLAGVNALCATIGKGSVAGILLVVNVTLIGVVSAISFVAFADLVAAMPSGTARARILLTEVGVGAALTAVVAATLSFVPDQHPLSRNIHLLWTAAVAMAISAAICRALPHRIVPRVHAAPGLHKLVYVGWTAIRTNGWYRRYLLVQVLFGSVVLGSSFHSIRVAAVPGDQPDEVVAVVLFVCVGLLGGIALWNRVRERFGLVGLFVGSALVSIAAAVLSIAFDLAGAWPNVVAIGLVIALVSIANQSVFTAGQLWIARDAEPGLRTSLISFGQLVINAGLVGMGLALGLIAQDHDAVWPVMIVLLLNLTAAYSATRFAPAKSVDVRGLPQVSRTSRPKTGG
Protein: Caspase-9 (Q9JHK1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Apoptotic protease-activating factor 1
- E3 ubiquitin-protein ligase XIAP
- Cytochrome c, somatic
- Caspase-3
- RING-type E3 ubiquitin transferase
- RING-type E3 ubiquitin transferase
- RAC-alpha serine/threonine-protein kinase
- Poly [ADP-ribose] polymerase 1
- RING-type E3 ubiquitin transferase
- Baculoviral IAP repeat-containing protein 5
Sequence:
MEEADRQLLRRCRVRLVRELQVAELWDALLSRELFTRDMIEDIQRAGSGSRRDQARQLVIDLETRGRQALPRFISCLEDTGQGSLASFLQSSGQAAKQDPEAVTPLDHLVPVVLGPMGLKSKEQKVVKLDPSQPALGNLTPVVLGPEELWPTRLRPEVLTPETPRPVDIGSGRAHDVCTPGKIERHADMAYTLDSDPCGHCLIINNVNFCPSSGLSTRIGSHVDCEKLQHRFCWLRFMVEVKNDLTAKKMVTALMEMAHRDHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIERIVNIFNGTGCPSLGGKPKLFFIQACGGEQKDHGFEVAFTSSQDKAFDSDSEPDAVPYQEGPRTLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGVLEQWARSEDLQSLLLRVANAVSEKGVYKQIPGCFNFLRKKLFFKTS
Protein: Beta-glucosidase 31 (AtBGLU31) (EC 3.2.1.21) (Q9FLU9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Glucan endo-1,3-beta-glucosidase 3
- Glucan endo-1,3-beta-glucosidase 4
- Ubiquitin-like superfamily protein
- Beta-glucosidase 27
Sequence:
MAIKLIALVITLCVASWDVAQGRSLRFSTTPLNRYSFPPHFDFGVASSAYQYEGAVEEGGRSLSIWDNFTHAFPERTNMDNGDVAVDFYHRYKEDIKLIKEMNMDSFRFSLSWSRILPSGKLSDGVNKEGVQFYKNLIDELIENGIKPFVTIYHWDIPQALDDEYGSFLSPRIIDDFRNYARFCFQEFGDKVSMWTTFNEPYVYSVSGYDAGNKAMGRCSKWVNSLCIAGDSGTEPYLVSHHLLLAHAAAVEEFRKCDKISQDSKIGIVLSPYWFEPYDSASNADKEAVERALAFNIGWHLSPLVFGDYPETIKISAGNRLPSFTKEQSMMVKNSFDFIGVNYYTARFVAHDLNVDISRPRFMTDQHLQYKLTNRTGDTISLESDGTKILWSYPEGLRKILNYIKNKYNNPTIYITENGFDDYENGTVTREEILEDTKRIEYHQKHLQELQKAITEDGCDVKGYFTWSLLDNFEWEHGYAVRFGLYYVDYKNGLQRHAKHSAMWFKHFLERSGKPMPMDLFKSVKRWWSTLQMI
Protein: Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96) (Q8NFI3)
Organism: Homo sapiens (Human)
Function: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}.
Interaction partners:
- Alpha-mannosidase 2C1
- Peptide-N
Sequence:
MEAAAVTVTRSATRRRRRQLQGLAAPEAGTQEEQEDQEPRPRRRRPGRSIKDEEEETVFREVVSFSPDPLPVRYYDKDTTKPISFYLSSLEELLAWKPRLEDGFNVALEPLACRQPPLSSQRPRTLLCHDMMGGYLDDRFIQGSVVQTPYAFYHWQCIDVFVYFSHHTVTIPPVGWTNTAHRHGVCVLGTFITEWNEGGRLCEAFLAGDERSYQAVADRLVQITQFFRFDGWLINIENSLSLAAVGNMPPFLRYLTTQLHRQVPGGLVLWYDSVVQSGQLKWQDELNQHNRVFFDSCDGFFTNYNWREEHLERMLGQAGERRADVYVGVDVFARGNVVGGRFDTDKSLELIRKHGFSVALFAPGWVYECLEKKDFFQNQDKFWGRLERYLPTHSICSLPFVTSFCLGMGARRVCYGQEEAVGPWYHLSAQEIQPLFGEHRLGGDGRGWVRTHCCLEDAWHGGSSLLVRGVIPPEVGNVAVRLFSLQAPVPPKIYLSMVYKLEGPTDVTVALELTTGDAGSCHIGGISVLNAETSSRHSLRPLRVPPTKLARWVGRCGRQLSGGWVQHCYEVSLRGCLLLDLLVCFSRPPGSREEESFTCRLGEIQVVDAASLLAPLPQVQAVTISHIRWQPSASEREGPPALLQLSCTLHWSFLLSQVRCFRIHCWGGMSDDSPGRELPRPEMPMFLGLAFATQYRIVDLLVEAAGPGQDRRMEFLVEPVPKEGFRVPQAEWGRAVLLYSAPA
Protein: RNA helicase (EC 3.6.4.13) (Q9VR29)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor CWC22 homolog
- ATP-dependent RNA helicase WM6
- RNA helicase
- LD47749p
- U3 small nucleolar ribonucleoprotein protein IMP3
- Bystin
- Probable ATP-dependent RNA helicase kurz
- Peptidyl-prolyl cis-trans isomerase
- ATP-dependent RNA helicase DHX15 homolog
Sequence:
MSTFKPKFLKPETDDAITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKEPPGDILAFLTGQEEVLEALDLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTKLFMNYVTVIKREWLTELAPHYYQQTTVRD
Protein: F-box and leucine-rich protein 22 (Q6P050)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:22972877}.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
Sequence:
MWPLLTMHITQLNRECLLHLFSFLDKDSRKSLARTCSQLHDVFEDPALWSLLHFRSLTELQKDNFLLGPALRSLSICWHSSRVQVCSIEDWLKSAFQRSICSRHESLVNDFLLRVCDRLSAVRSPRRREAPAPSSGTPIAVGPKSPRWGGPDHSEFADLRSGVTGARAAARRGLGSLRAERPSETPPAPGVSWGPPPPGAPVVISVKQEEGKQGRTGRRSHRAAPPCGFARTRVCPPTFPGADAFPQ
Protein: Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (HDP) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] (P04256)
Organism: Rattus norvegicus (Rat)
Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P09651}. Cytoplasm {ECO:0000250|UniProtKB:P09651}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. {ECO:0000250|UniProtKB:P09651}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein K
- Heterogeneous nuclear ribonucleoproteins C1/C2-like
- Heterogeneous nuclear ribonucleoprotein C
- Heterogeneous nuclear ribonucleoprotein U
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Polypyrimidine tract-binding protein 1
- Heterogeneous nuclear ribonucleoprotein A3
- RNA-binding motif protein, X chromosome
- Serine/arginine-rich splicing factor 1
- RNA binding motif protein, X-linked-like-1
Sequence:
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALCKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF
Protein: BPI fold-containing family B member 1 (Long palate, lung and nasal epithelium carcinoma-associated protein 1) (von Ebner minor salivary gland protein) (VEMSGP) (Q8TDL5)
Organism: Homo sapiens (Human)
Function: May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- BPI fold-containing family B member 2
- BPI fold-containing family A member 1
- BPI fold-containing family A member 2
- Mucin-5B
- BPI fold-containing family B member 6
- BPI fold-containing family A member 3
- Protein LEG1 homolog
- Secretoglobin family 3A member 1
Sequence:
MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHIIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGLINEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEASSEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQPDVLKNIITEIIHSILLPNQNGKLRSGVPVSLVKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ
Protein: Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) (O75151)
Organism: Homo sapiens (Human)
Function: Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:20129925}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
Interaction partners:
- AT-rich interactive domain-containing protein 5B
- Lysine-specific demethylase 3B
Sequence:
MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIEATPPQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASPTIPNLDLLEAHTKEALTKMEPPKKGKATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPGVFGALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTKPKLDSAAYKSDDSSDEGSLHIDTDTKPGRNARVKKESGSSAAGILDLLQASEEVGALEYNPSSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKSAGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKSAKRKLTPNTTSPSTSTSISAGTTSTSTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFTGAQAGRTSQPMAPGVFLTQRRPSASSPNNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL
Protein: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase (EC 4.1.3.44) (tRNA wybutosine-synthesizing protein 1) (Q08960)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:14562095}.
Interaction partners:
- tRNA wybutosine-synthesizing protein 3
- tRNA wybutosine-synthesizing protein 2
- tRNA wybutosine-synthesizing protein 4
- tRNA
- Protein CCC1
- Periodic tryptophan protein 1
- AP-1-like transcription factor YAP5
- Monothiol glutaredoxin-4
- Iron-sulfur assembly protein 1
- U3 small nucleolar ribonucleoprotein protein IMP4
Sequence:
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQKKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSKKNIGDNENTATEVEKAVNYPVTVDFTEVFRKPTKKRSSTPKVFSKNSSSNSRVGKKLSVSKKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLLNLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLVGYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLAETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKDSPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEVRHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPTKTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRGLPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAHSNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGNTRVYRKDKKKQNKENQETTTRETPLPPIPA
Protein: Cindoxin reductase (CdR) (EC 1.18.1.-) (NADPH-dependent flavodoxin/ferredoxin reductase) (NADPH-dependent flavodoxin/ferrodoxin reductase) (Q8VQF5)
Organism: Citrobacter braakii
Function: Involved in the degradation of cineol (eucalyptol). Catalyzes the reduction of cindoxin (CinC).
Interaction partners:
Sequence:
MSKLQHHSIGEVEPSIAIVGSGPAGCYTAQTLHKQWPSAQIVIFERLPVPYGLLRYGVSPDHQGTKAIARQFDRLFAEASVHFIGNVEVGKHISVEELQDAFDVVVLAAGLGADRPLPSLAGDAVYGAGQVMRWFNSHPDEQSFAPGFGATTTIIGNGNVAMDVVRLLAKHRDSFTGSDLDPQLIEKQPSRIHVVGRSPASAAKFDSMMIRELAEIDDAVFDVDVVDEPGHEDKRIHAKTKALLDLTAARAVPSPRVHVSFHFGWTPESLEPTGDGRTLRLVNTESRLAVKLIETDSVITAVGFGSGLRHEIDRVRFESAASDLDNGLLDTGLYCSGWFRRGPTGGIPANRLDAKMVCTRIIEDVASGAITPKKRGLEELATHLHPDTVDFTGWQRIDAVEASRTEHGRCRTKLPDIATMLDFARNRTHERTTDDTYRKQITDTVGHKEKR
Protein: 5-cytosine rRNA methyltransferase NSUN4 (EC 2.1.1.-) (5-cytosine tRNA methyltransferase NSUN4) (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 4) (mRNA cytosine C(5)-methyltransferase NSUN4) (EC 2.1.1.-) (Q96CB9)
Organism: Homo sapiens (Human)
Function: Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:22949673, ECO:0000269|PubMed:23022348}.
Interaction partners:
- Transcription termination factor 4, mitochondrial
- Mitochondrial ribosome-associated GTPase 1
- Mitochondrial assembly of ribosomal large subunit protein 1
- rRNA methyltransferase 2, mitochondrial
- Mitochondrial ribosome-associated GTPase 2
- 28S rRNA
- Large ribosomal subunit protein mL64
- Large ribosomal subunit protein uL2m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein mL62
Sequence:
MAALTLRGVRELLKRVDLATVPRRHRYKKKWAATEPKFPAVRLALQNFDMTYSVQFGDLWPSIRVSLLSEQKYGALVNNFAAWDHVSAKLEQLSAKDFVNEAISHWELQSEGGQSAAPSPASWACSPNLRCFTFDRGDISRFPPARPGSLGVMEYYLMDAASLLPVLALGLQPGDIVLDLCAAPGGKTLALLQTGCCRNLAANDLSPSRIARLQKILHSYVPEEIRDGNQVRVTSWDGRKWGELEGDTYDRVLVDVPCTTDRHSLHEEENNIFKRSRKKERQILPVLQVQLLAAGLLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQVQVEDLTHFRRVFMDTFCFFSSCQVGELVIPNLMANFGPMYFCKMRRLT
Protein: Serum response factor (D3ZHH8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Myocardin
- Myocardin related transcription factor A
- ELK4, member of ETS oncogene family
- Transcription factor GATA-4
- ETS domain-containing protein Elk-1
- Homeobox protein Nkx-2.5
- Nuclear factor of activated T-cells, cytoplasmic 3
- Nuclear factor of activated T-cells, cytoplasmic 4
- Nuclear factor of activated T-cells 1
- Nuclear factor of activated T-cells 2
Sequence:
MLPSQAGAAAALGRGSALGGSLNRTPTGRPGGSGGTRGANGGRVPGNGAGLGPGRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMELGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPSTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLADGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE
Protein: Uncharacterized protein Rv2567 (P9WL97)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Long conserved protein
- Uncharacterized protein Rv2569c
- Conserved protein
- Uncharacterized protein Rv2568c
- Uncharacterized NTE family protein Rv2565
Sequence:
MAPSASAATNGYDVDRLLAGYRTARAQETLFDLRDGPGAGYDEFVDDDGNVRPTWTELADAVAERGKAGLDRLRSVVHSLIDHDGITYTAIDAHRDALTGDHDLEPGPWRLDPLPLVISAADWEVLEAGLVQRSRLLDAILADLYGPRSMLTEGVLPPEMLFAHPGYVRAANGIQMPGRHQLFMHACDLSRLPDGTFQVNADWTQAPSGSGYAMADRRVVAHAVPDLYEELAPRPTTPFAQALRLALIDAAPDVAQDPVVVVLSPGIYSETAFDQAYLATLLGFPLVESADLVVRDGKLWMRSLGTLKRVDVVLRRVDAHYADPLDLRADSRLGVVGLVEAQHRGTVTVVNTLGSGILENPGLLRFLPQLSERLLDESPLLHTAPVYWGGIASERSHLLANVSSLLIKSTVSGETLVGPTLSSAQLADLAVRIEAMPWQWVGQELPQFSSAPTNHAGVLSSAGVGMRLFTVAQRSGYAPMIGGLGYVLAPGPAAYTLKTVAAKDIWVRPTERAHAEVITVPVLAPPAKTGAGTWAVSSPRVLSDLFWMGRYGERAENMARLLIVTRERYHVFRHQQDTDESECVPVLMAALGKITGYDTATGAGSAYDRADMIAVAPSTLWSLTVDPDRPGSLVQSVEGLALAAQAVRDQLSNDTWMVLANVERAVEHKSDPPQSLAEADAVLASAQAETLAGMLTLSGVAGESMVHDVGWTMMDIGKRIERGLWLTALLQATLSTVRHPAAEQAIIEATLVACESSVIYRRRTVGKFSVAAVTELMLFDAQNPRSLVYQLERLRADLKDLPGSSGSSRPERMVDEMNTRLRRSHPEELEEVSADGLRAELAELLAGIHASLRDVADVLTATQLALPGGMQPLWGPDQRRVMPA
Protein: LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) (Q14847)
Organism: Homo sapiens (Human)
Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
Subcellular location: Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the F-actin rich cortical cytoskeleton. {ECO:0000250}.
Interaction partners:
- Lipoma-preferred partner
- Zyxin
- Palladin
- Vasodilator-stimulated phosphoprotein
- Protein AF-17
- Kelch-like protein 41
- C-X-C chemokine receptor type 1
- TNF receptor-associated factor 4
Sequence:
MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI
Protein: Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) (Q64640)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P55263}.
Interaction partners:
- Adenosine deaminase
- Adenine phosphoribosyltransferase
- Purine nucleoside phosphorylase
- AMP deaminase 2
- Adenylosuccinate lyase
- Adenylate kinase 2, mitochondrial
- AMP deaminase 3
- AMP deaminase 1
- 5'-nucleotidase
- Ectonucleoside triphosphate diphosphohydrolase 1
Sequence:
MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATFFGCIGIDKFGEILKSKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLENNWMLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFISQFFKEALMEVMPYVDILFGNETEAATFAREQGFETKDIKEIARKTQALPKVNSKRQRTVIFTQGRDDTIVATGNDVTAFPVLDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH
Protein: Prolactin receptor (PRL-R) (Q2PBN9)
Organism: Bos taurus (Bovine)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU365035}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU365035}.
Interaction partners:
Sequence:
MFENAASRVVFILLLFLNVSLLNGQSPPEKPKLVKCRSPGKETFTCWWEPGTDGGLPTNYKLTYHQEGETLIHECPDYKTGGPNSCYFSKKHTSIWKMYVITVNAINQMGISSSDPLYVDVTYIVEPEPPANLTLELKHPEDRKPYLWIKWSPPTMTDVKSGWFIIQYEIRLKPEKATDWETHFTPKQTQLKIFNLYPGQKYLVQIRSKPDHGYWSEWSPESSIQIPNDFPVKDTSMWIFVAILSAVICLIMVWAVALKGYSMVTCILPPVPGPKIKGFDVHLLEKGKSEELLRALESHDFPPTSDCEDLLMEFIEVDDCEDQQLMPRPSKEHTEQGVKPMHLDLDSDSGRGSCDSPSLLSEKCDEPQAHPSKFHTPEGPEKLENPETNLTCLQAPQSTSGEGKIPYFLANGPKSSTWPFPQPPSLYSPRYSYHNIADVCELALGMAGTTATSLDQTDQHALKASKTIETGREGKATKQRESEGCSSKPDQDTVWPRPQDKTPLISAKPLEYVEIHKVSQDGVLALFPKQNEKFGAPEASKEYSKVSRVTDSNILVLVPDPQAQNLTLLEEPAKKAPPALP
Protein: Neurotensin receptor type 2 (NT-R-2) (NTR2) (High-affinity levocabastine-sensitive neurotensin receptor) (Q63384)
Organism: Rattus norvegicus (Rat)
Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Neurotensin/neuromedin N
- Neurotensin receptor type 1
- Sortilin
Sequence:
METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV