wanglab/gogpt-training-data huggingface dataset:
Protein: Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) (Q91XT6)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000269|PubMed:11526914}.
Interaction partners:
Sequence:
MAAEFIKSCCRGCLYGETEKQKFSVDRDFKASASSSQNTIGIPPLTSVLVKPQVGCNEDYLLSKLPCDGKEVQFVVPRFKLSYIQPRTQGIPSHLDELEGSARASFGDQKTELCSSFYHGPSYDVYNPCYMYQHFSPDLSRRFLPHCETKQLYGSVCDLRTSKLPGSSGLSKSMLDLTTSSQRFIQRHDSFSSVPSSSSSRKNSQGSNRSLDTITLSGDERDLGRLNVKLFYNSSAEQIWITVLQCRDISWPSSYGDTPTISIKGILTLSKPVHFKSSAKEGSNAIEFMETFVFAIKLQNLQAVRLAFKIQTQTPKKKTIGECSLSLRTLSTQEMEYSLEIIAPSKISVCQAELELGTCFQAVNSRIQLQILEAQYLPSSSTPLTLSFFVKVGMFSSGELIYKKKTRLLKASSGRVKWGETMIFPLIQTEKEIVFLIKLYSRSSVRRKHFVGQLWISEDSNNIEAVNQWKETITNPEKVVIKWHKLNPS
Protein: ATP-binding cassette sub-family C member 12 (Multidrug resistance-associated protein 9) (Q80WJ6)
Organism: Mus musculus (Mouse)
Function: Probable transporter, its substrate specificity is unknown.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96J65}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the midpiece of the sperm tail. {ECO:0000269|PubMed:17472575}.
Interaction partners:
Sequence:
MVGEGPYLISDLDRRGHRRSFAERYDPSLKTMIPVRPRARLAPNPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDINAKRFQILWEEEIKRVGPEKASLGRVVWKFQRTRVLMDVVANILCIVMAALGPTVLIHQILQHITSISSGHIGIGICLCLALFTTEFTKVLFWALAWAINYRTAIRLKVALSTLIFENLLSFKTLTHISAGEVLNILSSDSYSLFEAALFCPLPATIPILMVVCAVYAFFILGSTALVGISVYLIFIPIQMFMAKLNSTFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEESFINTIHDIRKREKKLLEKAGYVQSGNSALAPIVSTIAIVSTFTCHIFLKRKLTAPVAFSVIAMFNVMKFSIAILPFSVKAVAEASVSLRRMKKILIAKSPPSYITQPEDPDTILLLANATLTWEQEINRKSDPPKAQIQKRHVFKKQRPELYSEQSRSDQGVASPEWQSGSPKSVLHNISFVVRKGKVLGICGNVGSGKSSLISALLGQMQLQKGVVAVNGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSLPYGDLTEIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIKKTLKGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHIYNVAMVETLKESPAQRDEDAVLASGDEKDEGKEPETEEFVDTNAPAHQLIQTESPQEGIVTWKTYHTYIKASGGYLVSFLVLCLFFLMMGSSAFSTWWLGIWLDRGSQVVCASQNNKTACNVDQTLQDTKHHMYQLVYIASMVSVLMFGIIKGFTFTNTTLMASSSLHNRVFNKIVRSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVIMAAVFPVVLVVLAGLAVIFLILLRIFHRGVQELKQVENISRSPWFSHITSSIQGLGVIHAYDKKDDCISKFKTLNDENSSHLLYFNCALRWFALRMDILMNIVTFVVALLVTLSFSSISASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELLREYILTCVPEHTHPFKVGTCPKDWPSRGEITFKDYRMRYRDNTPLVLDGLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIIIDEVDICTVGLEDLRTKLTMIPQDPVLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEATASMDSKTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVGL
Protein: Zinc finger E-box binding homeobox 2 (A0A1B0GW50)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRALPLRGTLTRRRGRVCRGMARARRSTRKKARMATGSWADRMATRSSRRKRKKVKIKVWIRIPKRYEMKKRLEITPWTIVRRMGKWKPNQTTRKTIWKMACNKLLHFKLPIFFSSSIVTCLKTLLC
Protein: Probable bifunctional transcriptional activator/DNA repair enzyme AlkA (Regulatory protein AlkA) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase (EC 2.1.1.n11) (Methylphosphotriester-DNA methyltransferase); DNA-3-methyladenine glycosylase (EC 3.2.2.21) (DNA-3-methyladenine glycosidase)] (P9WJW3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity).
Interaction partners:
- Methylated-DNA--protein-cysteine methyltransferase
- DNA polymerase IV 1
- Probable exodeoxyribonuclease III protein XthA
- Protein RecA
- DNA polymerase I
- DNA polymerase IV 2
- Uncharacterized protein Rv1318c
- Adenine DNA glycosylase
- UvrABC system protein A
- Probable DNA polymerase III
Sequence:
MHDDFERCYRAIQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPFARNVRFLPTAAAAQGEGFRACKRCRPDASPGSPEWNVRSDVVARAMRLIADGTVDRDGVSGLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNLPFGDVAFAAGFSSIRQFNDTVRLACDGTPTALRARAAARFESATASAGTVSLRLPVRAPFAFEGVFGHLAATAVPGCEEVRDGAYRRTLRLPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDLDADPEAIVEALGADPDLRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAGRLVAAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLVLDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLGLRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQEKIA
Protein: DNA-directed RNA polymerase II subunit rpb4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (Q54S04)
Organism: Dictyostelium discoideum (Social amoeba)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase II subunit rpb2
- DNA-directed RNA polymerases I, II, and III subunit rpabc4
- DNA-directed RNA polymerases I, II, and III subunit rpabc5
- DNA-directed RNA polymerase II subunit rpb11
- DNA-directed RNA polymerases I, II, and III subunit rpabc1
- DNA-directed RNA polymerase II subunit rpb7
- DNA-directed RNA polymerase II subunit rpb3
- DNA-directed RNA polymerases I, II, and III subunit rpabc3
- DNA-directed RNA polymerases I, II, and III subunit rpabc2
- DNA-directed RNA polymerase subunit
Sequence:
MTDPLIKRSGIQEEEDLTTLKFPRDLKDAKFLLNSEVAILLEHRKGISESEGTEFPQNTLLIHLYYNSINDIIRTFHKTLAYAEKFSRYKNKTSIKQVRTALSKQNLEEFEIASLANLCPEISDEAKSLIPSLKKMEDDELQAILDELSNLRKFN
Protein: Tetratricopeptide repeat protein 23-like (Q6PF05)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25751302}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25751302}. Midbody {ECO:0000269|PubMed:25751302}. Note=Exhibits dynamic subcellular localization during the cell cycle. In prophase cells, detected on split centrosomes. Translocates to the mitotic spindles during metaphase and early anaphase, then to the midbody and cleavage furrow in late anaphase. {ECO:0000269|PubMed:25751302}.
Interaction partners:
- IQ domain-containing protein E
Sequence:
MQASPIRIPTVSNDIDWDFCFHMSQQTEIPAHQQTDELYPTGGCGESEEETKAKEKEKAIDCMSHPKEKLAQSQKKVAQLIKEKMNTQANKELIRCVILSRIIFGDHHWKCARALANLAYGYLTLRGLPVQAKKHATSAKNTLLTWKANTTSNKEKEEILEALVKLYYTLGVAWLLQNRGREAYFNLQKAERNMKELKELYKGGVCELQVSENDLTLALGRASLAIHRLNLALAYFEKAIGDVIAAKGDRTSDLISLYEEAAQIEQLRRNHNQAIQYLQQAHSVCVSLFTEVSPKTAEMSALLAKAYAMSGEAQHRDAVEIYFIRSINAYRATLGSEDFETLSTTEEFCKWLVQNGEKQDK
Protein: ATP-dependent RNA helicase DHX34 (U4PRA5)
Organism: Caenorhabditis elegans
Interaction partners:
- Neuroblastoma-amplified sequence
- UPF3 domain-containing protein
- Nonsense-mediated mRNA decay factor SMG8
- RNA helicase
- Nonsense-mediated mRNA decay factor SMG9
- PIN domain-containing protein
- Nonsense-mediated mRNA decay protein
- MIF4G domain-containing protein
- Probable small nuclear ribonucleoprotein G
- Uncharacterized protein byn-1
Sequence:
MYKLDQEEYEKHRGALFRHFLPDEPGTSGNRRGEKSTEQELIDTQRKSIQSYFNRFFRERKGETNDHFDVNRVKFDDLGIPQDTGGLNRIRFKGENLGIMPTQLGHITPWLYRHFEYAYHVALQFNQHQKFQKLQKLRKLQKELPIAERAGEIVELLKTNQVLIVAGDTGCGKSTQVPQYLLKAGFTGVACTQPRRIACTALARRVAYETLNQYGSEVAFQIRFETTKSQKTKLLFLTEGLLLRQMEKDSLLEKYNVIILDEVHERHLTSDLLIGLLRDLCTKRDDLKLILMSATINLDLFKGYFEGAPVVQVPGRLFPIDVRWHPIKQFIDQSDKKTHKIDPEPYLKILELIDKQFPSTQRGDALIFLNGVAEISMVAEHLKNYAELTNGWIILMLHSTLSVEEQDKVFDQAPVGIRKCILSTNVAETSVTIDGIRFVIDSGKVNLIKHEPGTGTQKLTEFWVSKASANQRKGRAGRTGPGICYRLYSQEQFEKMDDFTVSEINRVSLQEMALKMISLNLGLDPRTFPFIEKPSEDVLNEGLEVLKFQRVLRSDRGDILTLTALGNMVSKLPVEVPIAKMLVYGCVVDELEVMLTVAAGLSVQSPFTNRSYRELEIVERRASLTSPLGDPFTLISIFREWVLQKAFEGTARRWTMENGIDEHRLYEISKLRAQYRQILEDAGLVEKASAAETGEDDSRQRRIDQGEKRKLFDLKKSQRNNDRRQKVLNANKHFDKILEDKEEEDLEAEKDPLKADVKTVEFLLSHKQRDVENIRKTHKISRKTAEVVRVIIAAGLYPNFSILDPVNKYGYGQEMFTHTRLKPFTQIHPNSSIAQYHPETIDPRQGSDGFSRLHQIPFYGLLLETTKPYICNVMPVPAVYTLLVAQKIVIEDDWSQLSIDDFLELRFRSSTDCRSVLLDAKEIRYELTKGLAAKLVGEAGFSGRRRLAKYIDLLNQSIVEKGIEVAVRRNVHPPKVLTGIGIHSPDGGIDKEEDVDDLVQRFERDQEPVHSAREEELEDQKVLDELRADVMCPPTRDMIEEAEKLKELKKKEIPKESYYEKLLKRQKAKEDDEKTEKKPKLEPLDTMEE
Protein: Prespore-specific protein A (Cell surface antigen PsA) (Ponticulin-like protein G) (Protein D19) (P12729)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May bind F-actin and nucleates actin assembly.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Prestalk protein
- Extracellular matrix protein A
- Spore coat protein SP60
- Spore coat protein SP70
- Spore coat protein SP85
Sequence:
MKFQHTFIALLSLLTYANAYDYFTTTLANQNPVCASVDVIQNVCTEVCGRFVRYIPDATNTNQFTFAEYTTNQCTVQVTPAVTNTFTCADQTSSHALGSDWSGVCKITATPAPTVTPTVTPTVTPTVTPTPTNTPNPTPSQTSTTTGSASTVVASLSLIIFSMILSLC
Protein: Fertilization-influencing membrane protein (E9Q9R3)
Organism: Mus musculus (Mouse)
Function: Plays a role in sperm-oocyte fusion process during fertilization.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000305|PubMed:32295885}; Single-pass type I membrane protein {ECO:0000255}. Note=Localized to the equatorial segment of the sperm head. {ECO:0000269|PubMed:32295885}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305|PubMed:32295885}.
Interaction partners:
- Sperm-egg fusion protein LLCFC1
- Sperm-egg fusion protein TMEM95
Sequence:
MKLWLWVAVGVWMLMAELGTIETAPRRDGTRPSVSGARPQQVVNRLFFDYPDSDRASLLAVARFIGEKPITFVKTDSSPGLFQNILVGTLVVAFFFLLFQFCLHVNFQKGA
Protein: Melanocortin receptor 3 (MC3-R) (P32244)
Organism: Rattus norvegicus (Rat)
Function: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Pro-opiomelanocortin
- Agouti-related protein
- Growth hormone secretagogue receptor type 1
- Melanocortin 2 receptor accessory protein 2
- Appetite-regulating hormone
- Pro-neuropeptide Y
- Leptin
Sequence:
MNSSCCPSSSYPTLPNLSQHPAAPSASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIVVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALSLIVAIWVCCGICGVMFIVYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNGMNVG
Protein: Ribosome-inactivating protein gelonin (EC 3.2.2.22) (rRNA N-glycosidase) (allergen Gel m RIP) (P33186)
Organism: Suregada multiflora (False lime) (Gelonium multiflorum)
Interaction partners:
Sequence:
MKGNMKVYWIKIAVATWFCCTTIVLGSTARIFSLPTNDEEETSKTLGLDTVSFSTKGATYITYVNFLNELRVKLKPEGNSHGIPLLRKKCDDPGKCFVLVALSNDNGQLAEIAIDVTSVYVVGYQVRNRSYFFKDAPDAAYEGLFKNTIKTRLHFGGSYPSLEGEKAYRETTDLGIEPLRIGIKKLDENAIDNYKPTEIASSLLVVIQMVSEAARFTFIENQIRNNFQQRIRPANNTISLENKWGKLSFQIRTSGANGMFSEAVELERANGKKYYVTAVDQVKPKIALLKFVDKDPKTSLAAELIIQNYESLVGFD
Protein: PII, uridylyltransferase (DUF2921) (F4IEK8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 7
- Probable methyltransferase PMT26
- Sulfite exporter TauE/SafE family protein 4
- Heat shock 70 kDa protein 17
- Lung seven transmembrane receptor family protein
- Early nodulin-like protein 19
- Uncharacterized GPI-anchored protein At3g06035
- Transmembrane 9 superfamily member 12
- Iron-sulfur cluster co-chaperone protein HscB homolog
- At3g09570
Sequence:
MKTVINLLPLLFLSFGFLFSSLVIASFSEMEPVPMFESIGEHRDESAPKISYDRINDVKKKCKSVLSSASELKLEDISRTPRKSKRNLGFRYGDWNQDSGDSPILPFDSTNTLRNSSTKPMNLVSFSVTDLDLPHRTKKYIGVNGVLLLAITMFSELPSLRSYGLREFELWPSHTQLKISFQGIYVENDDDERVLCMLGETMLPSRDESDSSNPWKWVKEHDTPPLLQDDMILLLLRYPKSFTLTKRVIQGELTSLNQKPSLKLFDKIHLFSQLGKSVRYDFVSNDLVSKACDPYPYKNDTFTSSGSGGINVYKEKGFCDLLQRVTNRAPLTVVPNWKCHGTDEYCSKLGPFAFDKDIKSTDGSFKDVKLYMQNVHCEETAARSQSDAVTKVSAVFRAVHPNENLYISGMRSGIDNMTVTAEGIWKPSSGQLCMVGCRRGQVDGCNARICLYIPTTFSIRQRSILVGTFSCLNTEKNLTPSFFPLSFEKLVEPMDMQNYFHSSASHPFYSYSKLDDAGAILERNEEFSFGTIIKKSVMHFPKLEDSDDLLSSLSLLAEDLTFHTPAFTEKRASGTNFGMDVLSLGPLFGLFWRTSNFSIADQTTPYRTKAEYTEKQLLLNVSGQISLTGENFGNFSVLYLEGLYDEHVGKMYLVGCRDVRASWKILFESPDLEAGLDCLIDVVVSYPPIKSRWLADPTAKVSISSNRPEDDPLYFKPIKLKTTPIFYRRQREDILSRAGVEGILRVLTLTFSIGCITSLLFYVSSNTDSLPFVSLVMLGVQALGYSLPLITGAEALFKRKAASATTYETPSYDLQRSQWFNVIDYTVKLLVMVCFLLTLRLCQKVWKSRARLLTRTPQEPHKVPSDRRVLLVVLILHALGYIVALIRHPARADRLVGGSYGSNASNWWQTETEEYIGLVQDFFLLPQVIANAMWQIDSRQPLRKLYYFGITLVRLFPHAYDYIVGSVPDPYFIGEEHEFVNPNFDFFSKFGDIAIPVTAILLAVIVFVQQRWDYDKLSQALSFGRFRILPSRSVKYERVMSESEMVSGARVNGNRGDEE
Protein: Beta-alanine--pyruvate aminotransferase (Beta-A--Py AT) (EC 2.6.1.18) (Beta-alanine--pyruvate transaminase) (Omega-amino acid aminotransferase) (Omega-amino acid AT) (Omega-amino acid--pyruvate aminotransferase) (Omega-APT) (Q9I700)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Involved in the degradation of beta-alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. It can also accept both 4-aminobutyrate and (S)-alpha-methylbenzylamine (MBA) as amino-group donors in the presence of pyruvate as an amine acceptor.
Interaction partners:
- Beta-alanine degradation protein BauB
- Malonate-semialdehyde dehydrogenase
- Probable GABA permease
- Probable 3-hydroxyisobutyrate dehydrogenase
- Probable 3-hydroxyisobutyrate dehydrogenase
- Aspartate 1-decarboxylase
- 3-hydroxyisobutyrate dehydrogenase
- Probable 3-hydroxyacyl-CoA dehydrogenase
- Fatty acid oxidation complex subunit alpha
- Pantothenate synthetase
Sequence:
MNQPLNVAPPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHSRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSEIYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKGLHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVRFGGDTLQFGPTFNARPEELDRLFDAVGEALNGIA
Protein: Nitrate reductase [NADPH] (NR) (EC 1.7.1.3) (P22945)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
Interaction partners:
- Nitrite reductase [NAD
- Nitrate transporter
- Nitrate reductase
- Nitrate/nitrite transporter
- MOSC domain protein
- MOSC domain protein
- Sulfite reductase subunit beta
- Uncharacterized protein
- Nitrogen assimilation transcription factor nirA
- Dihydroorotate dehydrogenase
Sequence:
MSTTVTQVRTGSIPKTLKTSQIRVEEQEITELDTADIPLPPPSKEPTEVLSLDKTTPDSHVPRDPRLIRLTGVHPFNVEPPLTALFQQGFLTPPELFYVRNHGPVPHVRDEDIPNWELRIEGLVEKPITLSFKQILQNYDQITAPITLVCAGNRRKEQNTVRKSKGFSWGSAALSTALFTGPMMADIIKSAKPLRRAKYVCMEGADNLPNGNYGTSIKLNWAMDPNRGIMLAHKMNGEDLRPDHGRPLRAVVPGQIGGRSVKWLKKLIITDAPSDNWYHIYDNRVLPTMVTPDMSSQNPSWWRDERYAIYDLNVNSAAVYPQHKETLDLAAARPFYTAKGYAYAGGGRRITRVEISLDKGKSWRLARIEYAEDKYRDFEGTLYGGRVDMAWREACFCWSFWSLDIPVSELASSDALLVRAMDEALSLQPKDMYWSVLGMMNNPWFRVKITNENGRLLFEHPTDITGSSGWMEQIKKAGGDLTNGNWGERQEGEEPVEAEPVVEVNMKKEGVTRIIDLEEFKKNSSDERPWFVVNGEVYDGTAFLEGHPGGAQSIISAAGTDASEEFLEIHSETAKKMMPDYHIGTLDKASLEALRKGNADTTDSSSDPRPTFLTPKAWTKATLTKKTSVSSDTHIFTLSLEHPSQALGLPTGQHLMLKTPDPKSSSSGSIIRSYTPISPSDQLGMVDILIKIYAETPSIPGGKMTTALDTLPLGSVIECKGPTGRFEYLDRGRVLISGKERFVKSFVMICGGTGITPVFQVLRAVMQDEQDETKCVMLDGNRLEEDILLKNELDEFEALAGKKEKCKIVHTLTKGSESWTGRRGRIDEELIRQHAGTPDRETMVLVCGPEAMEKASKKILLSLGWKEENLHYF
Protein: Mitochondrial transcription rescue factor 1 (Q9CQF4)
Organism: Mus musculus (Mouse)
Function: Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability. Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q9P0P8}.
Interaction partners:
- Bublin coiled-coil protein
Sequence:
MAVPGVRLLTGALRKPDAWTRLWGVIQGTSSHKLCASWNRYLYFSSTKLNTSNYKTLFRNIFSLRLPELLVSPECYFPFSIRLKSNINSKKSTKKTLQKEADEEDSDEETSYPERSEQEEELESEPGVAKDYKDLEKVVQSFRYDVILKTGLDVGRNKVEDAFYKGELRLNGEKLWKKSRTVKVGDTLDLITGENKETGTEVVMRILLKKVYEEKTENDKHRVVLRRWKSLKLPKKTLSK
Protein: Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] (P54290)
Organism: Rattus norvegicus (Rat)
Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P54289}.
Interaction partners:
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Voltage-dependent L-type calcium channel subunit beta-1
- Voltage-dependent L-type calcium channel subunit beta-2
- Voltage-dependent R-type calcium channel subunit alpha-1E
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Voltage-dependent L-type calcium channel subunit beta-3
- Voltage-dependent calcium channel gamma-1 subunit
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Voltage-dependent N-type calcium channel subunit alpha-1B
Sequence:
MAAGCLLALTLTLFQSWLIGPSSEEPFPSPVTIKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAEKVQAAHQWREDFASNEVVYYNAKDDLDPERNESESGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFAADRLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFTFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYRYLALVLPTYSFYYIKAKIEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPREYCNDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRILLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPRMMRHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSITDILQIGWWATAAAWSILQQLLLSLTFPRLLEAVEMEEDDFTASLSKQSCITEQTQYFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESKGTCPCDTRLLMQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWSIFGLQFILLWLVSGSRHYLW
Protein: cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (E7FC09)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Valine--tRNA ligase
- Leucyl-tRNA synthetase 2
- Phosphatidylinositol glycan anchor biosynthesis, class L.
- Asparaginyl-tRNA synthetase 2
- Valyl-tRNA synthetase 2
- Tyrosine--tRNA ligase, cytoplasmic
- Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial
- Glutaminyl-tRNA synthetase
- Prolyl-tRNA synthetase 2
- Arginyl-tRNA synthetase 2
Sequence:
MTMRLASALILNSGFRIRREIHSGVTKTSLLCRRTACSRTERGWVKPVGFDTGVTAYNSLTKKKEPLILSQEKIATWYSCGPTVYDHAHLGHACSYVRFDILQRILSRLFGINVIHVMVITDIDDKIIQRSLEENISPITLARMHEEEFKKDMLALRVLPPVVYMRVTENIPQIIAFIERIIGNGHAYVTSQGNVYFNTKSISHRYGKLVNLGGNAGEQGVQDKENSRDFALWKASKPFEPYWESPWGQGRPGWHIECSTIASSVFGHQLDIHSGGIDLAFPHHENEIAQSEAYHQCEQWGNYFLHSGHLHLKGSVEKMSKSLKNYVTIKDFLASYTANEFRLFCLLTKYRSAIDYSDASMNEAQSTLSTISAFFHNAQAYMQGHMQCQPVEEGFLWERLSNTQTSVHKMLADDFDTPKAVDAIMSLIYHGNCQLQPATKVDGPRSPAVFGAIMSYVMEIMSVFGVDLSDKTEVQVSSGVLNNVVEELVHFRSEVRKFALSVEDQAPQESQTGNKNQKRHHQPDRLHLSLLKACDALRNNLAPLGVHIKDRGTNSTWEVTKAETRK
Protein: Cytochrome P450-DIT2 (EC 1.14.14.-) (Cytochrome P450 56) (P21595)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in spore wall maturation. Thought to catalyze the oxidation of tyrosine residues in the formation of LL-dityrosine a precursor of the spore wall.
Interaction partners:
- Spore wall maturation protein DIT1
- pH-response transcription factor pacC/RIM101
- C-22 sterol desaturase ERG5
- Dityrosine transporter 1
- L-2-aminoadipate reductase
- Uncharacterized protein YEL023C
Sequence:
MELLKLLCLILFLTLSYVAFAIIVPPLNFPKNIPTIPFYVVFLPVIFPIDQTELYDLYIRESMEKYGAVKFFFGSRWNILVSRSEYLAQIFKDEDTFAKSGNQKKIPYSALAAYTGDNVISAYGAVWRNYRNAVTNGLQHFDDAPIFKNAKILCTLIKNRLLEGQTSIPMGPLSQRMALDNISQVALGFDFGALTHEKNAFHEHLIRIKKQIFHPFFLTFPFLDVLPIPSRKKAFKDVVSFRELLVKRVQDELVNNYKFEQTTFAASDLIRAHNNEIIDYKQLTDNIVIILVAGHENPQLLFNSSLYLLAKYSNEWQEKLRKEVNGITDPKGLADLPLLNAFLFEVVRMYPPLSTIINRCTTKTCKLGAEIVIPKGVYVGYNNFGTSHDPKTWGTTADDFKPERWGSDIETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEMRISLAEMLKQFRWSLDPEWEEKLTPAGPLCPLNLKLKFNENIME