Protein: Dynein-1-alpha heavy chain, flagellar inner arm I1 complex (1-alpha DHC) (Dynein-1, subspecies f) (Q9SMH3)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for assembly of the I1 inner arm complex and its targeting to the appropriate axoneme location. Also required for phototaxis.
Subcellular location: Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Interaction partners:
Sequence:
MDRRLEWVKEKACLGLGVEPNLFEAAIANPESRARVTAFLDGTVTSSALLFALEEATIYVEEYQEVLAEEQAPEAEDGEGEEHDGQEPGEAGGEGAEGSTAPGDSGDGQPEDAPAAAAEANGANPEDEAAAPADGAADGAAGEGGEEGDGAEGDEPPAPPAPKYVRRVISVPKVVSKLNVALGSLPEELSVFPVFYFILNRSGHVAAEELDSAVEFGLLSEGPSLRILEQMLSSVFVPILVQMSGGDVASGGVLMQSMTDNSHRELLGNMQKFHSQVTQALQQLTGDVTLQLPDFPLEDMDRAAADTDLVMQLEQYMAEWSQVLASVLQRESQKHPTGKGPLAEIEFWRERNAVLSSLYEQLNLPQVKRMILVVEKGSDDRNLMAGFKSQLGELTKLATEARDNVKFLTTLERHFKNIATGPLGGILDTLPPMMNALRMVWIISRHYSDDQRMGSLFQRIAREIGDRVEAAVDLRHIFRMTSADAVELLKVCKSVLEHWLQTYMAMREKIELSGRDARWEFPKQLLFARTNYMAEICTDLIEMVEIVDDFFRFLGPELKTVTGDTAGIDRVVHRVVAMYEPIESISFNVFDYGNQHEWKAAKQQFYADNEDIKEATRELIDTSFRKLRSAEGACELLQSFKSIKSKGAIQKQVMNKFNDILEQFAREIEQTADIFERNKDAPPVTKNQPPVAGAIKWVRSLLERLKRTMAKLLSTEEEIIRTTELGQAVESKFKSFARSVMLTEKKWFSSWSDSINGVAMQHLKQTIFRRSAATNRVEVNFHPDLVRLIRETRYLDRMGFPIPEIALNVALQEDKFLQWLEGLNSMLFKYYESIDQLTPVERELMERKLEELESCLQPGFTILNWNSLGITEFIGTCDKAIATFQQLVKQVQKNSGIIEQVVYAIAGAQLVTEPEEGAEVMDLQEFYEDIERQRLAALESLVKKYRTISPLLGKIEEVVAGTNSGKSPALSSYYSFWERAIFNALNTMVLCAMTKLQDMIEQRSKHAEGGRKPPLFKVTVSLQSVDVVVQPPMTEVNKALGRLVRSLVESTKAFVRWMDGTCVETPEQRGATDDDEPIVFTFYWDVAANPQVIKTMLNLNQSIQRAITSVNKYAESWRRHQALWKTDKNSVLDKFKARDPSAAQFEDKLSKYAKMATEISAQAKDFDQDFIRVSCHALASSVCDEAQAWVRAIAQTMRELDAVTESQLRDKIAKYQTALHRPPDTLEELKQVLNTVNTIRGESMVMELRYADLEERYRTRLLYATNPEEESQCAHELASASQVRALWTELLNEAEAVDWSLEETKKKFSETTRSQVSDFAAITAELWEKFRTTGPGLPTVELASGLDELHKYESNLADALRQREQLVLAEKLFGMEITAYPELAQLESEIRKLAQVYGVYAEHAEAVRQYGGQLWSELDVGKMMAGTEAILTKLRKLKSLKLLPVYELVEKEIQGFYNSLPLMKELKSEALRKRHWTRLMEVTGQEFDMDPKTFTLGNMFAMQLHKYAEEIGKITNAAVKELTIESEIRKLADVWREQRFELGKYMKGPEDRGWVLRSTEDILVLLEDMGLNLQSMMASPFVRPFLTEVRAWEQKLSLIGECIEVWMHVQRKWMYLESIFVGSDDIRHQLPAEAKRFDNIDRQWQKIMNDTAKNTVVLDACMADGRLDLLKSLSEQLEVCQKSLSEYLDTKRCAFPRFYFISDDELLSILGTSDPTSVQEHMLKLFDNCAALVFGRGNKTITGMVSSEKEGFEFRNVVPIEGAVELWMTNVEAEMRKTLYQITKEGIFFYAKTPRTKWISENLGMVTLVGSQIWWTWETEDVFRRVRDGNKHSMKEFAAKLTGQLSELTSMVRSDLSNEVRKKVNTLIIIDVHARDIIDTYVRDSIVDAREFAWESQLRFYWDRQQDDILIRQCTGLFKYGYEYMGLNGRLVITALTDRCYMTLTTALTYRLGGAPAGPAGTGKTETTKDLAKSMALLCVVFNCGEGLDYKAMGSIFSGLVQCGAWGCFDEFNRIEAEVLSVVSSQIKNIQEALKNDLTRFQFEGKEISIDPRTGIFITMNPGYAGRTELPDNLKALFRPVTMVVPDLEQICEIMLFSEGFDSAKVLAKKMTVLYKLSREQLSKQHHYDFGLRALKSVLVMAGSLKRGAPDMSEQLVLMRALRDMNLPKFIFDDVPLFLGLINDLFPGMDCPRVRYPQFNDVVEADLADQGFKVLTEPSEQVDKVVQLYEVMMTRHTTMVVGQTGGGKTVILNTLARAQTKLGKKTHLYTINPKAISVAELYGVLDKDTRDWTDGLLSNIFREMNKPLPAERDEARYLVFDGDVDAVWVENMNSVMDDNKLLTLPNGERIRLQNHCKLLFEVFDLQYASPATISRCGMVYVDSRNLGYKPYIYTWLNSRAKQAEVDILRGLFEKYAVPSVDWILEGIDGEELVRRPKQAVPVTNLNMITQLCNLLNATITDHPRMSDPQILEAIFIFCTIWSLGAAIVQRPESPDRDRFDAFVKHIASMGLVDGERVAATQLPARSLYEYCFDTNEGVWKSWRSYLQPYEPPADGAFAKILVPTVDVVRSTWLLNTVVAAGKPCLFVGESGTAKSVTIANYLAHLDSTINIVLNVNFSSRTSSLDVQRAIEDSTEKRTKDTYGPPMGKRLLMFIDDLNMPRVDTYGTQQPIALLKLFIERKGLYDRGKELSWKNMKDVQVVGAMGPPGGARNPVDPRFISLFSVFEIQFPSNENLRTIYQAILSRHLAKLPTDEIRDQLGERLTDVTLELYNFIIDKLPPTPSRFHYIFNLRDLSRIYEGLLLTVGDVFKTPEQFLRLWRNECLRVLHDRLISTDDKRVMTERLEALVQQKFPNLAAHTLASPVLFGDFKNVINELQGEGEVAPRMYDDLGDYNSIKPLFEDVMTNFYNRKRKPMNLVFFEDALEHLTRIHRTLRLPQGNCLLVGVGGSGKQSLSKLAAFTAGCEVFEITLTRGYDELAFREDLKRLYAMLGSDNKRVMFLFTDAHVADEGFLELINNMLTSGMVPALYDGAEKDGLIGSVRAEVEKKGLLATKESCWSYYVDKCRNNLHVVLAMSPVGETLRSRCRNFPGMVNNTVIDWFEPWPEQALTSVASVFLAEEALPEALRPQIVEHMVTVHQSVRTFSTRFLEELRRYNYVTPKNYLDFINNYKRALATNRRTIEDTVTRLSGGLEKLIQAAVEVDAMQKELSQAQVVVAQATKECNELLEVISTNTVDVETKAKAAAIKEAQLKVDSEQIAIEKAEAEAALEEAIPALEEAAAALQDLSKDHITEIRSYAKPPEQVQKVCECVVILRNIKDVSWLGAKSMMADGNFLRSLVEFDKDSLTDKQVKKVKEYFKDPKAPLTYDSLRAISTAGAGLLKWVLAMVNYNNVARTVEPKRKKVAESEKNLRIAQKDLASTKLELQSLNDQLGKLRTQFEEKTAEQQDLKAKADLMERRLIAASKLIAGLGSERERWTRDIADLESRRDRLIGDCLLTSSFLSYTGAFTATYRHAMVYEMWQDDVKARGVPVTQPFRLEALLTSDVETTGWASEGLPSDELSIQNGILTVRANRWPLCIDPQMQAVNWIKSREGKMLEGKVKTFNDSDFLKQLELSIQYGFPFLFENLDEYIDPVIDPVLEKNLVPGDGKFVIKLGDKEVEWDSNFRLYMTSKLSNPHYGPEISGKTMIINYGVTQQGLTEQLLNVTLRHERSDLEEAREALIKQMSENKATLQALEDTLLRELSNAQGNILDNSELIATLESAKLKAVEIAEKLEASKVTAAEIEETRVRYSPAAKRGAILFFVIAGLSAITNMYEYSLASFLVVFNGSLHSSRRDASIEGRLRNIIDTLTYDVYAYTCLGLFERHKLMFSFQMTCKILEGDTPLDPQLLDFFLKGNLSLEKAARRKPFDWFPDAGWQDLMRLVELGQKKIGADGRMHALGSLANDVESDEAAWRTWYDLEAPEEAELPCGYQSFLSDFEKLCLMRCLRMDRVTVGITRFVIGVMGEKYVQPPVLEYRSIYKQSTETTPIVFVLSPGADPAFDVFKLGEEMGFRPGAKLKYMALGQGMGPKAQELIETGATRGLWIMLQNCHLLPTWLKTLEKILEKITKPHADFRLWLTTELTDRFPLGVLQRSLKVVTEPPNGLKLNMRQSYSKITEEVLADCPHQAFRPLVYVLGFFHAVVQERRKYGKLGWNVPYDFNETDFRISMALISTYLTKAWDAQDDLIPWGTLRYLIGEAMYGGRVSDSYDRRILTTYLDEYLGDFLFDTFQPFRFYACKDYEIAIPQTGSRDTYLKAVEALPLVQSPEAFGLNANADISYYTSATKAIWTDLVDLQPRTGGGGGGVAREEFIGGVARDIAAKIPEPFDLPQLRKELGTPSPTQVVLLQELERWNSVLGVMVSSLRDLQRALSGEIGFSSRLEELASSLYNGKLPAMWARLNPATEKALGAWMLWFGRRYRQYKDWTEHGEPKVIWLSGLHIPETYIAALVQAACRDKGWPLDKSTLYTKVTKFTDPYQVSERPKYGCYMSGLYLEGAAWDLEASQLRKQDPKVLVNELPILQVIPIEANKLKLANTFRAPVYVTQARRNAMGVGLVFDADLASAEHSSHWVLQGVALVLNIDQ