wanglab/gogpt-training-data huggingface dataset:
Protein: Epoxide hydrolase 3 (EH3) (EC 3.3.2.10) (Abhydrolase domain-containing protein 9) (Q9H6B9)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin.
Subcellular location: Microsome membrane {ECO:0000305|PubMed:22798687}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MPELVVTALLAPSRLSLKLLRAFMWSLVFSVALVAAAVYGCIALTHVLCRPRRGCCGRRRSASPACLSDPSLGEHGFLNLKSSGLRLHYVSAGRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVILGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGAPMSVYQDYSLHHISQFFRSHYMFLFQLPWLPEKLLSMSDFQILKTTLTHRKTGIPCLTPSELEAFLYNFSQPGGLTGPLNYYRNLFRNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIGSRFVPGRLEAHILPGIGHWIPQSNPQEMHQYMWAFLQDLLD
Protein: Regulatory protein SdiA (P07026)
Organism: Escherichia coli (strain K12)
Function: Activates cell division by specifically increasing transcription from one of the two promoters that lie immediately upstream of the ftsQAZ gene cluster. Activates ydiV expression in response to extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6).
Interaction partners:
- Response regulator UvrY
- S-ribosylhomocysteine lyase
- Multiple antibiotic resistance protein MarR
- L-cystine transport system ATP-binding protein TcyN
Sequence:
MQDKDFFSWRRTMLLRFQRMETAEEVYHEIELQAQQLEYDYYSLCVRHPVPFTRPKVAFYTNYPEAWVSYYQAKNFLAIDPVLNPENFSQGHLMWNDDLFSEAQPLWEAARAHGLRRGVTQYLMLPNRALGFLSFSRCSAREIPILSDELQLKMQLLVRESLMALMRLNDEIVMTPEMNFSKREKEILRWTAEGKTSAEIAMILSISENTVNFHQKNMQKKINAPNKTQVACYAAATGLI
Protein: Histone H3 (P61830)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP, UAF seems to stimulate basal transcription to a fully activated level.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H2B.2
- Histone H2A.2
- Histone acetyltransferase GCN5
- Histone chaperone RTT106
- Histone H2A.1
- Histone acetyltransferase RTT109
- FACT complex subunit SPT16
- Histone H4
- Histone chaperone ASF1
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
Sequence:
MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRFQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQESVEAYLVSLFEDTNLAAIHAKRVTIQKKDIKLARRLRGERS
Protein: Endothelial transcription factor GATA-2 (GATA-binding protein 2) (Q924Y4)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). Plays an important role in the regulation of phagocytosis in alveolar macrophages, particularly during P.carinii infection.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- TAL bHLH transcription factor 1, erythroid differentiation factor
- LIM domain binding 1
- Runt-related transcription factor 1
- Rhombotin-2
- Zinc finger protein, multitype 1
- Zinc finger protein Gfi-1
- Transcription factor PU.1
- CCAAT/enhancer-binding protein alpha
- Erythroid transcription factor
- Protein lyl-1
Sequence:
MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASPSAGGSVARGEDKDGVKYQVSLSESMKMEGGSPLRPGLAPMGTQPATHHPIPTYPSYVPASAHEYGSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG
Protein: Protein phophatase 2C family protein (AFU_orthologue AFUA_1G06860) (Q5B158)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Pyruvate dehydrogenase E1 component subunit alpha
- Pyruvate dehydrogenase E1 component subunit beta
- Acetyltransferase component of pyruvate dehydrogenase complex
Sequence:
MRRAALQALRSSRRAPAWRVGGRTPPISFTSSPSLGLRSYSTPKLSASLQSSMHLRTFSVAAVSAVVASGAWYAYQGDGSQTPAAAGTSSQTRSFTSTAHAEQPSEPSRRALLVDNDQFYTATLSGEQPLQKNTDDSDRRLLEMLTPEQATQKLRKNEESYLVNRGKGVVRYDVVQVPSNSPIEDDHAEKIVEVPASTSAANEGQSSSDWMFWAVFDGHSGWTTSAKLRNVLISYVARELNATYKSASSDPSLVLPSSEAVDAAIKQGFVRLDNDIVHGSVNQVFKSNSRRAAAELLAPALSGSCALLAFYDSQTRDLKVACAGDSRAVLGRRSENGKWTATPLSEDQTGGTPSEMKRLREEHPGEPNVVRNGRILGQLEPSRSFGDAFYKWSKETQEKIKRQFFGRTPHPLLKTPPYVTAEPIITTTKVDPSQGDFLVLATDGLWEMLSNEEVVGLVGQWIEEQKAAAGAGTGNKSWVRSLFGSQPTQLPVEAPKETSTDGQRRPIRQQQYDISGAASRFVVEDKNAATHLVRNAMGGKDKDMLCALLTLPSPYSRRYRDDVTVEVIFFGESPDNRTISINEEASASEDNIKAKL
Protein: Choline/ethanolamine transporter FLVCR1 (Feline leukemia virus subgroup C receptor-related protein 1) (Feline leukemia virus subgroup C receptor) (hFLVCR) (Heme transporter FLVCR1) (Q9Y5Y0)
Organism: Homo sapiens (Human)
Function: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15369674, ECO:0000269|PubMed:22483575, ECO:0000269|PubMed:37100056, ECO:0000269|PubMed:38778100}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion membrane {ECO:0000269|PubMed:23187127}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Hemopexin
- Heme transporter HRG1
- Proton-coupled folate transporter
Sequence:
MARPDDEEGAAVAPGHPLAKGYLPLPRGAPVGKESVELQNGPKAGTFPVNGAPRDSLAAASGVLGGPQTPLAPEEETQARLLPAGAGAETPGAESSPLPLTALSPRRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWIKCGSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQNDTNLLACNISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTALIKSDLRRHNINIGITNVDVKAIPADSPTDQEPKTVMLSKQSESAI
Protein: Erythrocyte membrane protein 1, PfEMP1 (Q8IBW7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MARDPRGGGSEEDDIDHKSVKHLLDSIGKIVHDQVKNGADGTAKKYIKELKGDLSKATFSSEETASSIETCYLVKEYYNNHVNGGDVSGERNPCRKEDVKRFSDKEGAECTNNKINCNKGGCGACAPYRRLHVCDKNMEKMGRTSMTTHKLLAEVCYAAKYEGASITLHYPQYQEKYDDSPSEMCTMLARSFADIGDIVRGKDLFIGYNQKDRKEKEQLQNKLKYIFKKIHEKLDSEAQTRYNDATGNFYQLREDWWTANRATIWEAMTCSEDLKNSSYFRQTCSDERGGAQANDKCRCPNGNNQVPTYFDYVPQYLRWFEEWAEDFCRKKKKYVDIVKKFCREGENGKEKYCSLNGYDCTKTKLAVGKYRMGNQCTKCFFACYPYENWIEKQKEQFDKQKKIYDKEIKIYTEGAPRSSSRKKRDAGGTTNYDGYIKKFYGELKNHGYGDVNNFLEKLSDEDVCKKVQDTQGGKINFKNVKSSSASVPGGGNDVVAASGDRGKGASADSNSNKTFYRSEYCQPCPYCGMKKKSDGSGGWEKRSETDNCTRGNLYKPKGDAEATPIKILKSGKGHKDIEKKLNEFCQEQNRSDGSSSGGGGKNSNNQELYEEWKCYNDVEKDGQDGVDDDDEEDVQKVKNAGGLCILQKTNGKENVNKQKTFYDFFYYWVAHMLKDSIHWRTRRLRKCINDGTTMKCINGCHGKCDCFQKWIEQKKKDEWKPIKDHFYKQEGFGEQGSEKLPHYMVLEIVLEEEFLKEVSEDESENNSENPHEDAQETKRIKDMFEKKKKKNNDEVASNEETIIDFMLEEELKDAKQCIEKHTCPPQEGLARSATDPQPRSEEKEEEEEDDDEDDEDGDEVEEEEPHTEDTTEGSATEEKEAPKVVEPAVKKEEVNVCSIVGGILTGSGNLNDACSQKYGYPQRHWGWKCIPSGDNTTTREGSGEATKSGATTGSGKDGATGGSICVPPRRRRLYVTPLTRLAGGDGNTQAGETTQGNGASTETPEASLRRAFVESAAVETFFLWHKYKTVKQKELDEKKKQQQENVLSQLSGDTISGEQNPQSKLEKGEIPDDFKRLMFYTLGDYRDIVVRGVADDKNGGNNIILNASGNKQDMDKIQKKIDKILKQSASKPGQEPNSKREEFWTTHGPDIWKGMVCALTYKESKNGDKTIVKDGAVYDKFFGENNNDNPGSKPKTNGTYQENYDYNIVTLKEDESGGGPKPAGVNEAPPKLSDFVLRPTYFRYLEEWGETFCSERMKRLKQIYEDCKVGENGDRRRDGKKNPKCSCYGEDCEEIFSKKYDTVSSLECPNCAKYCRFYKRWIDRKRKEYDKQEKIYVQQKSNYENESNNHDKGFCTKLKENYTDAAKFLERLKDGPCKNDSEEGKKGRDKLDFNEPDETFKDADNCKPCSEFKINCKNGKCSDEEKRKCNGTTVITKDNIEKMKDSNGNVDMLVIDKSGNGSQNDLKDCEGKGIFTGIRKEQWKCRNVCGYIVCGLKGDNGQKVNEKHIIQIRALVTHWVQYFLEDYNRIKQKISHCIKNSDGSKCENKCNDKCNCASKWIDEKSTEWTNLKNLYLQQYGGNDSGESYPVKTILQELQPKTELNKAIKPCGDLHQFEESRHCNGAASSENGKPQKKDIVECLLDRLKKKATSCPAPTSGENPTQCQEPPLVEDNDEAIEEENSVTQPNICPPQTPPKQEEKDTCEPAAEETEPAEEKSSEEPDKQKPDQDKSADTPARAPAAPPSTPGPQPLPSDNTSDILKTTIPFGIALALTSIALLFLKKKTKHPVDLFSVINIPKSDYDIPTKLSPNRYIPYTSGKYRGKRYIYLEGDSGTDSGYTDHYSDITSSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSGNNTTASGKNTPSDTQNDIQNDGIPSSKITDNEWNTLKDDFISNMLQNEPNTEPNILHDNLDNNTNTTMSRDNMEEKPFITSIHDRDLYTGEEISYNINMSTNSMDDTKYVSNNVYSGIDLINDTLSGNAHIDIYDEVLKRKENELFGTNHVKQTSIHSVAKLTNSDPIHNQLELFHTWLDRHRDMCEQWSNKEELLDKLKEEWENETHSGNTHPSDSNKTLNTDVSIQIDMDHEKRMKEFTNMDTILEDLEKYNEPYYDVQDDIYYDVNDHDASTVDSNAMDVPSKVQIEMDVNTKLVKEKYPIADVWDI
Protein: Alpha-keto-acid decarboxylase (Q6QBS4)
Organism: Lactococcus lactis
Interaction partners:
Sequence:
MYTVGDYLLDRLHELGIEEIFGVPGDYNLQFLDQIISREDMKWIGNANELNASYMADGYARTKKAAAFLTTFGVGELSAINGLAGSYAENLPVVEIVGSPTSKVQNDGKFVHHTLADGDFKHFMKMHEPVTAARTLLTAENATYEIDRVLSQLLKERKPVYINLPVDVAAAKAEKPALSLEKESSTTNTTEQVILSKIEESLKNAQKPVVIAGHEVISFGLEKTVTQFVSETKLPITTLNFGKSAVDESLPSFLGIYNGKLSEISLKNFVESADFILMLGVKLTDSSTGAFTHHLDENKMISLNIDEGIIFNKVVEDFDFRAVVSSLSELKGIEYEGQYIDKQYEEFIPSSAPLSQDRLWQAVESLTQSNETIVAEQGTSFFGASTIFLKSNSRFIGQPLWGSIGYTFPAALGSQIADKESRHLLFIGDGSLQLTVQELGLSIREKLNPICFIINNDGYTVEREIHGPTQSYNDIPMWNYSKLPETFGATEDRVVSKIVRTENEFVSVMKEAQADVNRMYWIELVLEKEDAPKLLKKMGKLFAEQNK
Protein: PH and SEC7 domain-containing protein 3 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Pleckstrin homology and SEC7 domain-containing protein 3) (Q2PFD7)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide exchange factor for ARF6.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23603394}. Cell projection, ruffle membrane {ECO:0000269|PubMed:23603394}. Postsynaptic density {ECO:0000269|PubMed:16707115}. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. {ECO:0000269|PubMed:23603394}.
Interaction partners:
- ADP-ribosylation factor 6
Sequence:
MEGRNAAAEPFVWVNSASAHSQSVAKAKYEFLFGKSEEKTPDSSDHGGSTLLPPTVTNEFPEYGTMEEGGEGLRASLDFDAKSPPCRLPGQQAVHLLAGQDSILNSVTEGPNDAPQCHPQEQSLQPIDSLISALKATEARIASGTFQATKVLDKDANFSVYQVDKELSTASHKPQRAHRTFPVGPGKSPDIPLSAEVPTEENLSLHIQEDLSALLPEEAQAHRSQITNYRRQGPLRVPESACPVSSSSAGSHNPVDRVGALREQRSDLGREHPRGYDRGGSMGRQGRIKHVEFQGVEILWTGEEAESRHPPERTASPVSKEFAKRPSHSSPACGVCSTSTHLTGDVWDETCKAPSERPGTSAGTLSPMPLGESGEDDVFLRESKEHLEENFAIQGDKERILDQEEHLRGDDDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSVGGQHDVLSVSADGGIVMGYSAGITNGLHDSANSVYTRGPQEIAFWGSRDRCFAEGKTTGVDAGSEMGSTDILEKETTESLSNGTNSNVEAAKRLAKRLYHLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFLKAFSLVGETQERERVLIHFSNRYFSCNPDTITSKDGVHCLTCAMMLLNTDLHGHVNIGKKMTCQEFITNLQGVNEGGDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSEGTDEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKSLSDEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEIYVSVLKEGGKELLTTDGNEPVGLKKSHSSPSLNPDASPVTAKVKRNVSERKDHRPETPGIKQKVT
Protein: Transcription factor LAX PANICLE 1 (Basic helix-loop-helix protein 123) (OsbHLH123) (Protein LAX PANICLE) (Q7XAQ6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor that seems to regulate organogenesis in postembryonic development. Involved in the regulation of shoot branching by controlling axillary meristem initiation. Functions in association with LAX2 to regulate the process of AM formation. Possesses transactivation activity in yeast.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Os06g0144000 protein
- histidinol-phosphate transaminase
- Double strand break repair protein, putative, expressed
- Imidazole glycerol phosphate synthase hisHF
- GHMP kinases putative ATP-binding protein, expressed
- DNA polymerase lambda
- Os07g0511500 protein
- Histidinol dehydrogenase, chloroplastic
- Os01g0685500 protein
- Putative DNA ligase 4
Sequence:
MHDPRGFPIHPQPYHLHPTAGGLGEGRMRGGGRRRPGAKLSTDPQSVAARERRHRISDRFRVLRSLVPGGSKMDTVSMLEQAIHYVKFLKAQVTLHQAALVQHEEGCQHADVAAAFSAADADLALELNHRHGGAGDDDAGMTTLEMAPMQEAVGYGDGPAHQMMQQALDPAGQLMMGGAHQLPPLPCCVFVQETDPSCYSVCNVHGEESGAQGSY
Protein: Heme binding protein (Q9LZQ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Peroxynitrite isomerase Rv2717c
- SOUL heme-binding family protein
- Translocator protein homolog
- Cytochrome B5 isoform C
- Cytochrome b5 isoform E
- Cytochrome B5 isoform D
- Putative sterol 14-demethylase-like protein
- Cytochrome b5 isoform A
- Cytochrome b5 isoform B
Sequence:
MLQLVVVAWLLIFTAETVVPHQESGEWSCESDSEIQVLADFRPGIITLDGHNDDWKDIDGSEFPLRPALDPDSDHEYDAGKMTVKALHDGRDIYFLLEIDGNYAYDKGENNKCPSVALMFQIGDQATYHNMGGCKEGTDSCTSKACRGFEVDIMHFSIGNAIPGRLYGGNPIDNGEGNGGDRFGHLVDIYAWNPHCRYLDGLGPSGNDSSAQNDWHGAWWHSSFTTLSGYVEEDSPYTPDGKKGTYYFEFSRPLRTMDRLQQDVQFTLGSPAKMSVAFWYPVDSKPWHGSGHYTINCDWTPLDISSGSSSGLTASTVKGSSDGASITAILLSMISLVFSGFIAYRLFSPRNVPFTPMENNL
Protein: Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7) (Q6DHK8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix (By similarity). Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis (By similarity). Does not show transport activity towards bile acids or steroid sulfates.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q0GE19}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q0GE19}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q0GE19}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q0GE19}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q0GE19}.
Interaction partners:
- P3 protein precursor
- GDT1 family protein
- Ileal sodium/bile acid cotransporter
- Solute carrier family 10 member 4.
- Store-operated calcium entry-associated regulatory factor
Sequence:
MGLIARVRKEWFIIGIVLVITFAKLQPSVGVKGGPLHPEITITYVAVSVIFFNSGLSLKTEELASALMHVKLHFFVQTFTLVFFPIAIWLLLKVLALTAINEWLLRGLQTVACMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVVTPLLLLVFLGSSSSVPFTSIFSQLFMTVVVPLIVGQVCRRFLRECLDRRKPPFGAVSSVVLLMIIYSTFCDTFNNPNIELDHLSLLTVVFIIFSIQLSFMALIFFLSTRKSSGFSAADSVAIMFCATHKSLTLGIPMLKIVFEGYEHLSLISVPLLIYHPAQILLGSVLLPSIKTWMSGRQKTLTPI
Protein: DNA-binding transcriptional dual regulator CRP (Catabolite activator protein) (CAP) (Catabolite gene activator) (cAMP receptor protein) (CRP) (cAMP regulatory protein) (cAMP-activated global transcriptional regulator CRP) (P0ACJ8)
Organism: Escherichia coli (strain K12)
Function: A global transcription regulator, which plays a major role in carbon catabolite repression (CCR) as well as other processes. Binds cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site overlap, CRP making multiple contacts with RNAP. Class III promoters require multiple activator molecules, including at least one CRP dimer. CRP can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA (about 87 degrees), bringing upstream promoter elements into contact with RNAP. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. High levels of active CRP are detrimental to growth. In CCR it prevents expression of genes involved in catabolism of nonpreferred carbon sources when glucose is present. CCR involves cAMP, adenylate cyclase (cyaA), CRP and the EIIA-Glc component of the PTS (crr). In the presence of glucose, EIIA-Glc is dephosphorylated, and does not activate adenylate cyclase, leading to reduced cAMP and thus decreased CRP activity. When glucose is absent cAMP binds to CRP, upregulating expression of genes involved in the consumption of non-glucose carbon sources. Also plays a role in many other processes.
Interaction partners:
- RNA polymerase sigma factor RpoD
- DNA-directed RNA polymerase subunit alpha
- Adenylate cyclase
- DNA-directed RNA polymerase subunit beta
- HTH-type transcriptional repressor CytR
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit omega
- RNA polymerase sigma factor RpoS
- 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
- DNA-binding protein Fis
Sequence:
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR
Protein: Succinate dehydrogenase assembly factor 3, mitochondrial (SDH assembly factor 3) (SDHAF3) (Q8SZ16)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SdhB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q04401}.
Interaction partners:
- Succinate dehydrogenase assembly factor 4, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- LYR motif-containing protein 2
- Protoheme IX farnesyltransferase, mitochondrial
- Succinate dehydrogenase assembly factor 4
- LYR motif-containing protein 4 homolog
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- RH44771p
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
Sequence:
MSRILMSQLTHPQRVRLLYKTILRLHRGLPAELRALGDNYVRDEFRRHLKCNPMEAQLFMTEWARYASTITQQLGIRGKPKGELGEEIDPKTVEMLKDDQVVQLYELMLAAKGVEDAQGK
Protein: UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) (Bacteriophage N4 adsorption protein C) (UDP-GlcNAc-2-epimerase) (P27828)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. Also involved in bacteriophage N4 adsorption.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02028, ECO:0000269|PubMed:8226648}.
Interaction partners:
- UDP-N-acetyl-D-mannosamine dehydrogenase
- Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- UDP-N-acetyl-D-mannosaminuronic acid transferase
- dTDP-glucose 4,6-dehydratase 2
- dTDP-4-amino-4,6-dideoxygalactose transaminase
- ECA polysaccharide chain length modulation protein
- dTDP-fucosamine acetyltransferase
- Bifunctional protein GlmU
- Lipid III flippase
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Sequence:
MKVLTVFGTRPEAIKMAPLVHALAKDPFFEAKVCVTAQHREMLDQVLKLFSIVPDYDLNIMQPGQGLTEITCRILEGLKPILAEFKPDVVLVHGDTTTTLATSLAAFYQRIPVGHVEAGLRTGDLYSPWPEEANRTLTGHLAMYHFSPTETSRQNLLRENVADSRIFITGNTVIDALLWVRDQVMSSDKLRSELAANYPFIDPDKKMILVTGHRRESFGRGFEEICHALADIATTHQDIQIVYPVHLNPNVREPVNRILGHVKNVILIDPQEYLPFVWLMNHAWLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVTAGTVRLVGTDKQRIVEEVTRLLKDENEYQAMSRAHNPYGDGQACSRILEALKNNRISL
Protein: U-box domain-containing protein 51 (Plant U-box protein 51) [Includes: E3 ubiquitin ligase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase); Serine/threonine-protein kinase (EC 2.7.11.-)] (Q9FKG5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as an E3 ubiquitin ligase.
Interaction partners:
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- NADH dehydrogenase flavoprotein 1, mitochondrial
- UDP-glycosyltransferase 73C7
Sequence:
MGDGALIVAVAIKGNNSKTKGVVRWALQEFASQEHVVFKLLHVQPRDSNSVSTTRKDLTTSVYKKDVDRKTREMLLPSRDMFVHREVQLDIMVLESDDIADAISKAVQDHGISELVIGASSSIIFSWKLKRSNLSSRIADATPRFCSVHVISKGKLLNVRKSDMDTETSIADDRSESRFSSDSHSGTVSSTSSHQFSSTPLLFQRIQALTTVNQKVGTNIGKQNNEPHHHHHNRAGSLDVDESKLLNQKGFYRTSSSGIGYGGSDISSWRSSQMEEASSSSTYSDPTSSSSQIHKDFELEKLKIELRHIKGMYAVAQSEVIDASKKMQDLNQRRSEEATRLKNLTIREEEADEVVEMERERQEDAENEAELVRECIERETEERLEAEARAEEVRKEKQRLEDALEGGPLQRQQYMKFEWEEIVEATSSFSDELKIGVGGYGSVYRCNLHHTTVAVKVLHSDKSSLTKQFHQELEILSKIRHPHLLLLLGACPERGSLVYEYMHNGSLEERLMKRRPNVDTPQPPPLRWFERFRIAWEIASALYFLHTNEPRPIVHRDLKPANILLDRNNVSKIGDVGLSKMVNLDPSHASTVFNETGPVGTFFYIDPEYQRTGVVTPESDIYAFGIILLQLVTARSAMGLAHSIEKALRDQTGKFTEILDKTAGDWPVKEAKEMVMIGLRCAEMRKRDRPDLGKEILPVLERLKEVASIARNMFADNLIDHHHNAPTHFYCPITKDVMENPCVASDGYTYEKRAIKEWLQKNHKSPMTDLPFPSDSLLPNHSLLSAIKEWRSQLIK
Protein: Transcription factor BC1 (Basic helix-loop-helix protein 81) (OsbHLH081) (Protein BU1-LIKE 1 COMPLEX 1) (OsBC1) (Q0J0G7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription activator that contributes, together with LO9-177 and ILI5/BUL1, to the promotion of leaf inclination and grain size by modulating cell elongation. Involved in the RLI1-dependent modulation of leaf inclination by promoting lamina joint cell elongation, especially in response to phosphate (Pi) availability.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:27879391}.
Interaction partners:
Sequence:
MAGFSHLPQQMEHGLITNNGFLFCHGSHGGAATTTAPAIPEDASMETSSVVLDTSPQDKKRKPREEDTASLNSAHSKEAKENGRKRGGKKHSRDQMEEEAPQGFIHVRARRGQATDSHSLAERVRRERISERMRMLQALVPGCDKVTGKALILDEIINYVQSLQNQVEFLSMRIASLSPVLYGFGIDSDAFSDHSQKMEGMFHEAVAIPASVLNRGSSPAQSHAIMDTSNTSPTPYTLQVQGGSNNNSLSQDNGSYIMQTVGEPRQELFNQVVLNNYMCSFQ
Protein: Cholecystokinin (CCK) [Cleaved into: Cholecystokinin-70 (CCK70); Cholecystokinin-8 (CCK8); Cholecystokinin-7 (CCK7)] (Q9PU41)
Organism: Gallus gallus (Chicken)
Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.
Subcellular location: Secreted.
Interaction partners:
- G_PROTEIN_RECEP_F1_2 domain-containing protein
- Cholecystokinin receptor type A
- Appetite-regulating hormone
- Pro-glucagon
- Somatostatin
- Pro-neuropeptide Y
- Peptide YY-like
- Neurotensin.
- Motilin
- Insulin
Sequence:
MYGGICICVLLAALSVSSLGQQPAGSHDGSPVAAELQQSLTEPHRHSRAPSSAGPLKPAPRLDGSFEQRATIGALLAKYLQQARKGSTGRFSVLGNRVQSIDPTHRINDRDYMGWMDFGRRSAEEYEYSS
Protein: Kinase (EC 2.7.-.-) (Q9VPR6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Inositol-pentakisphosphate 2-kinase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Kinase
- Kinase
- Multiple inositol polyphosphate phosphatase 1
- Multiple inositol polyphosphate phosphatase 1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
- Uncharacterized protein, isoform C
- inositol-polyphosphate 5-phosphatase
- LD06095p
Sequence:
MAKSDQELPEGFRQLKTQVAGHTFEESNAEAVGLLQDSKAGCVLKPLGKPECGERELRFYESLAEAGASGDNDLLALLRGHVPRFYGPLKLVVNRRERTFLRLEDLTRSYAKPCVMDVKMGKRTWDPESSPNKRKVEEAKYVMCKQKLGLCLPGFQVYLPKEEHTQETTILRHGKDYGKSLNVEGFKQTMALFFNASTSDSKSRRAGCELLLKEVLRQLQEILAWFQRQRLLHFYASSLLICYDYSRLADPPKPLINGYHQNDDDPATWVRVKMIDFAHVYPAEQGLPDENYMFGLQSLIEVVQSILHR