Protein: Huntingtin (Huntington disease protein homolog) (HD protein homolog) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] (P51111)
Organism: Rattus norvegicus (Rat)
Function: May play a role in microtubule-mediated transport or vesicle function.
Subcellular location: [Huntingtin]: Cytoplasm {ECO:0000250|UniProtKB:P42858}. Nucleus {ECO:0000250|UniProtKB:P42858}. Note=Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner. {ECO:0000250|UniProtKB:P42858}.; SUBCELLULAR LOCATION: [Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:P42858}.
Interaction partners:
- Cellular tumor antigen p53
- Huntingtin-associated protein 1
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Huntingtin-interacting protein 1
- Histone lysine acetyltransferase CREBBP
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Cyclic AMP-responsive element-binding protein 1
- 40-kDa huntingtin-associated protein
- RE1-silencing transcription factor
- Beclin-1
Sequence:
MKAFESLKSFQQQQQQQQPPPQPPPPPPPPPQPPQPPPQGQPPPPPPLPGPAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSLRNSPEFQKLLGIAMELFLLCSDDASRRRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTVRRTAAGSAVSICQHSRRTQYFYNWLLNVLLGLLVPMEEDHPTLLILGVLLTLRCLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPELLQALTTPGGLGQLTLVREEAGGRGRSGSIVELLAGGGSSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVSSSAFAASVKSEIGGELAASSSGVSTPGSVGHDIITEQPRSQHTLQADSVDLSGCDLTSAATDGDEEDILSHSSSQFSAVPSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGADSQYLGVQIGQPQEEDREAAGVLSGEVSDVFRNSSLALQQAHLLERMGHSRQPSDSSVDKFVSKDEVAEAGDPESKPCRIKGDIGQPNDDDSAPLVHCVRLLSASFLLTGEKKALVPDRDVRVSVKALALSCIGAAVALHPESFFSKLYKVPLSTMESTEEQYVSDILNYIDHGDPQVRGATAILCGTLVYSILSRSRLRVGDWLGTIRALTGNTFSLVDCIPLLQKTLKDESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLLIDMLPLKNSSYWLVRTELLETLAEIDFRLVSFLEAKAESLHRGPHHYTGFLKLQERVLNNVVIYLLGDEDPRVRHVAATTLTRLVPKLFYKCDQGQADPVEAVARDQSSVYLKLLMHETQPPSHFSVSTITRIYRGYSLLPSVTDVTMENNLSRVVAAVSHELITSTTRALTFGCCEALCVLSAAFPVCTWSLGWHCGVPPLSASDESRKSCTVGMASMILTLLSSAWFPLDLSAIQDALILAGNLLAASAPKSLRSSWASEEEGSSAATRQEEIWPALGDRTLVPMVEQLFSHLLKVINICAHVLDDETPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQTSTPMSPKKGGEASTASRQSDTSGPVTASKSSSLGSFYHLPSYLRLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEVLGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSSNPSKSQCRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQADQEHDASGWFDVLQKVSAQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQVADIILPMLAKQQMHIDSHEALGVLNTLFEILAPSSLRPVDMLLRSMFITPSTMASVSTVQLWISGILAILRVLISQSTEDIVLSRIQELSFSPYLISCPVINRLRDGDSNPTLGERSRGKQVKNLPEDTFSRFLLQLVGILLEDIVTKQLKVDMSEQQHTFYCQELGTLLMCLIHIFKSGMFRRITAAATRLFTSDGCEGSFYTLDSLNARVRAMVPTHPALVLLWCQILLLINHTDHRWWAEVQQTPKRHSLSCTKSLNPQISAEEDSGSAAQLGMCNREIVRRGALILFCDYVCQNLHDSEHLTWLIVNHIQDLISLSHEPPVQDFISAIHRNSAASGLFIQAIQSRCENLSTPTTLKKTLQCLEGIHLSQSGAVLTLYVDRLLGTPFRALARMVDTLACRRVEMLLAANLQSSMAQLPEEELNRIQEHLQNTGLAQRHQRLYSLLDRFRLSTVQDSLSPLPPVTSHPLDGDGHTSLETVNPDKDWYLQLVRSQCWTRSDSALLEGAELVNRIPAEDMSDFMMSSEFNLSLFAPCLSLGMSEIAGSQKSPLFEAARRVTLDRVTNVVQQLPAVHQVFQPFLPTEPTAYWSKLNDLFGDTTSYQSLTTLARALAQYLVVLSKVPAPLHLPPEKEGHTVKFVVMTLEALSWHLIHEQIPLSLDLQAGLDCCCLALQVPGLWGVLSSPEYVTHTCSLIHCVRFILEAIAVQPGDQLLGPESRSHTPRAVRKEEVDSDIQNLSHITSACEMVADMVESLQSVLALGHKRNSTLPSFLTAVLKNIVVSLARLPLVNSYTRVPPLVWKLGWSPKPGGDFGTVFPEIPVEFLQEKEVLKEFIYRINTLGWTSRTQFEETWATLLGVLVTQPLVMEQEESPPEEDTERTQIHVLAVQAITSLVLSAMAVPVAGNPAVSCLEQQPRNKPLKALDTRFGRKLSMIRGIVEQEIQEMVSQRENTATHHSHQAWDPVPSLLPATTGALISHDKLLLQINSEREPGNMSYKLGQVSIHSVWLGNNITPLREEEWDEEEEEEADAPAPTSPPVSPVNSRKHRAGVDIHSCSQFLLELYSRWILPSSAARRTPVILISEVVRSLLVVSDLFTDVPQFEMMYLTLTELRRVHPSEDEILIQYLVPATCKAAAVLGMDKTVAEPVSRLLESTLRSTHLPSQIGALHGILYVLECDLLDDTVKQLIPVVSDYLLSNLKGIAHCVNIHSQQHVLVMCATAFYLMENYPLDVGPEFSASVIQMCGVMLSGSEESTPSVIYHCALRGLERLLLSEQLSRLDTESLVKLSVDRVNVQSPHRAMAALGLMLTCMYTGKEKASPGRASDPSPATPDSESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDVMNKVIGEFLSNQQPYPQFMATVVYKVFQTLHSAGQSSMVRDWVMLSLSNFTQRTPVAMAMWSLSCFLVSASTSPWVSAILPHVISRMGKLEQVDVNLFCLVATDFYRHQIEEEFDRRAFQSVFEVVAAPGSPYHRLLACLQNVHKVTAC