wanglab/gogpt-training-data huggingface dataset:
Protein: Xyloglucan galactosyltransferase MUR3 (EC 2.4.1.-) (Protein KATAMARI) (Protein MURUS 3) (AtMUR3) (Protein SHORT ROOT IN SALT MEDIUM 3) (Q7XJ98)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the attachment of the Gal residue on the third xylosyl unit within the XXXG core structure of xyloglucan, the principal glycan that interlaces the cellulose microfibrils in plant cell wall. Associates with other xyloglucan-synthesizing enzymes to form multiprotein complexes for xyloglucan synthesis in the Golgi. Interacts with actin and is required for the proper endomembrane organization and for the cell elongation. Not involved in the trafficking from the endoplasmic reticulum to the vacuoles. Involved in salt stress tolerance. Participates in the control of the expression of genes encoding for proteins involved in reactive oxygen species (ROS) detoxification under salt stress. May contribute to the maintenance of the proper organization of actin microfilaments during salt stress-induced ROS production.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:15863516}; Single-pass type II membrane protein {ECO:0000305|PubMed:15863516}. Golgi apparatus membrane {ECO:0000269|PubMed:25392066}; Single-pass type II membrane protein {ECO:0000305|PubMed:25392066}.
Interaction partners:
- Xyloglucan 6-xylosyltransferase 2
- Galactoside 2-alpha-L-fucosyltransferase
- Xyloglucan glycosyltransferase 4
- Xyloglucan 6-xylosyltransferase 1
- Probable xyloglucan 6-xylosyltransferase 5
- GDP-mannose 4,6 dehydratase 2
- Probable arabinosyltransferase ARAD1
- UDP-arabinose 4-epimerase 1
- UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase
- Probable xyloglucan glycosyltransferase 6
Sequence:
MFPRVSMRRRSAEVSPTEPMEKGNGKNQTNRICLLVALSLFFWALLLYFHFVVLGTSNIDKQLQLQPSYAQSQPSSVSLRVDKFPIEPHAAPSKPPPKEPLVTIDKPILPPAPVANSSSTFKPPRIVESGKKQEFSFIRALKTVDNKSDPCGGKYIYVHNLPSKFNEDMLRDCKKLSLWTNMCKFTTNAGLGPPLENVEGVFSDEGWYATNQFAVDVIFSNRMKQYKCLTNDSSLAAAIFVPFYAGFDIARYLWGYNISRRDAASLELVDWLMKRPEWDIMRGKDHFLVAGRITWDFRRLSEEETDWGNKLLFLPAAKNMSMLVVESSPWNANDFGIPYPTYFHPAKDSEVFEWQDRMRNLERKWLFSFAGAPRPDNPKSIRGQIIDQCRNSNVGKLLECDFGESKCHAPSSIMQMFQSSLFCLQPQGDSYTRRSAFDSMLAGCIPVFFHPGSAYTQYTWHLPKNYTTYSVFIPEDDVRKRNISIEERLLQIPAKQVKIMRENVINLIPRLIYADPRSELETQKDAFDVSVQAVIDKVTRLRKNMIEGRTEYDYFVEENSWKYALLEEGQREAGGHVWDPFFSKPKPGEDGSSDGNGGTTISADAAKNSWKSEQRDKTQ
Protein: Kinesin-like protein KIF11-A (Kinesin-5) (Kinesin-related motor protein Eg5-2) (XLEg5K2) (Q91783)
Organism: Xenopus laevis (African clawed frog)
Function: Plus end-directed motor protein required for establishing a bipolar spindle. Associates with both interphase and spindle microtubules. May be involved in nuclear divisions taking place during the development of unfertilized eggs. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (By similarity).
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Concentrated around the polar ends of both meiotic and mitotic spindles.
Interaction partners:
Sequence:
MSSQNSFMSSKKDDKGKNIQVVVRCRPFNQLERKASSHSVLECESQRKEVCVRTGEVNDKLGKKTYTFDMVFGPAAKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSSDEEFTWEQDPLAGIIPRTLHQIFEKLSEIGTEFSVKVSLLEIYNEELFDLLSPSPDVGERLQMFDDPRNKRGVIIKGLEEISVHNKDEVYQILERGAAKRKTASTLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERAPHIPYRESKLTRILQDSLGGRTKTSIIATVSPASINLEETMSTLDYASRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRELATAREKNGVYLSNENYEQLQGKVLSQEEMITEYSEKIAAMEEEIKRIGELFADNKKELEECTTILQCKEKELEATQNNLQESKEQLAQEAFVVSAMETTEKKLHGTANKLLSTVRETTRDVSGLHEKLDRKRAVEQHNSQVHENFAEQINRRFSVIQQTVDEYSVKQQGMLDFYTNSIDDLLGASSSALSATATAVAKSFASVQETVSKQVSHSVEEILKQETLSSQAKDDLQKLMTAHRTGLEQALRTDLLPVVTAVLDLNSHLSHCLQSFLGVADKIDSHKEDMNSFFTEHSRSLHKLRLDSSSALSSIQSEYESLKEEIATAQSTHSEGVNNLISSLQNQLNLLAMETRQQFSGFLSKGGKLQESVGCLQQDLDLVSSDAIECISSHHSKFTEQSQAVTVEIRQLAGSNMSTLEESSKQCEKLTNSINTICQESQQWCESAGQKMDSLLEEQVCYLHSSKKQIQTLHKDVEDGCGSSVVEITDRVNVQCQAQEKALTSLVEQVKDDKEMLGEQRLELNEQVQSGLNKVHVYLKEELRNDVPTGTTPQRRDYVYPSLLIKTKPRDVLLEQFRQQQQEYLESICSVISEAVEPPVEQDSLEDEPPVAVNDSVISEKSCIDLSMTCQEKGGVPFFQQKKALRKEKENRGNATLLERSKIMDEVEQSLPKSKLPLRMQN
Protein: Forkhead box Q1a (Forkhead box protein Q1a) (A0A0R4IJS9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
- Guanine nucleotide-binding protein subunit gamma
- MAM domain-containing 2b
Sequence:
MSMHSSSATGSYTALSLFELSEALPMKLEVFCGSHYDSKPAELCSDAEGSIPSPVSAEEELGSDGDCVAHSPAPVADTKGKPYTRRPKPPYSYIALIAMAIRDSNSGRLTLAEINDYLMKKFPFFRGSYTGWRNSVRHNLSLNDCFLKVLRDPSRPWGKDNYWMLNPHSEYTFADGVFRRRRKRISKKTGREPEGPVQTHALDSNDSIATPPSSGKFTSSFAIESILSRPFRREDRPVLSPDTWPGGVDTVLPYVMLRSYGALEDPSMSRRQRDFFAFQLPPECLSIPHTSAAVPAPATAGYHPFKIDYLLS
Protein: SH3 domain-binding protein 2 (3BP-2) (Q06649)
Organism: Mus musculus (Mouse)
Function: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism (By similarity).
Interaction partners:
- Proto-oncogene vav
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Poly [ADP-ribose] polymerase tankyrase-2
- Guanine nucleotide exchange factor VAV3
- Guanine nucleotide exchange factor VAV2
- Poly [ADP-ribose] polymerase tankyrase-1
- Tyrosine-protein kinase SYK
- Tyrosine-protein kinase ABL1
- E3 ubiquitin-protein ligase RNF146
Sequence:
MAAEEMQWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLLKWPLRFVIIHKRCIYYFKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHISKKHRTWFFSASSEDERKSWMAFVRREIGHFHEKKELPLDTSDSSSDTDSFYGAVERPIDISLSSYPMDNEDYEHEDEDDSYLEPDSPGPMKLEDALTYPPAYPPPPVPVPRKPAFSDLPRAHSFTSKSPSPLLPPPPPKRGLPDTGSAPEDAKDALGLRRVEPGLRVPATPRRMSDPPMSNVPTVPNLRKHPCFRDSVNPGLEPWTPGHGTSSVSSSTTMAVATSRNCDKLKSFHLSSRGPPTSEPPPVPANKPKFLKIAEEPSPREAAKFAPVPPVAPRPPVQKMPMPEATVRPAVLPRPENTPLPHLQRSPPDGQSFRGFSFEKARQPSQADTGEEDSDEDYEKVPLPNSVFVNTTESCEVERLFKATDPRGEPQDGLYCIRNSSTKSGKVLVVWDESSNKVRNYRIFEKDSKFYLEGEVLFASVGSMVEHYHTHVLPSHQSLLLRHPYGYAGPR
Protein: Scavenger receptor class B member 1 (SR-BI) (B7ZKQ9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane, caveola {ECO:0000256|ARBA:ARBA00004189}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004189}.
Interaction partners:
Sequence:
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKEKCYLFWSSSKKGSKDKEAIQAYSESLMTSAPKGSVLQEAKL
Protein: Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) (P97292)
Organism: Mus musculus (Mouse)
Function: The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Histidine decarboxylase
- Potassium-transporting ATPase alpha chain 1
- Potassium-transporting ATPase alpha chain 2
Sequence:
MEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
Protein: Securin-2 (Pituitary tumor-transforming gene 2 protein) (Q9NZH5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Separin
- Cell division cycle protein 20 homolog
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-B1
- Securin
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 10
- Mitotic checkpoint protein BUB3
- Cell division cycle protein 23 homolog
Sequence:
MATLIYVDKEIGEPGTRVAAKDVLKLESRPSIKALDGISQVLTRRFGKTYDAPSALPKATRKALGTVNRATEKSVKTNGPRKQKQPSFSAKKMTEKTVKTKSSVPASDDAYPEIEKFFPFNLLDFESFDLPEERQIAHLPLSGVPLMILDEEGELEKLFQLGPPSPVKMPSPPWECNLLQSPSSILSTLDVELPAVCYDIDI
Protein: Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) (Q91VJ5)
Organism: Mus musculus (Mouse)
Function: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (By similarity). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner (By similarity). Can activate transcription directly or via association with the transcription machinery (By similarity). May be involved in ATXN1 mutant-induced cell death (By similarity). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (By similarity). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (By similarity). Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol (By similarity). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:23512658}. Nucleus speckle {ECO:0000269|PubMed:23512658}. Cytoplasmic granule {ECO:0000250|UniProtKB:O60828}. Note=Colocalizes with SRSF2 in nuclear speckles (PubMed:23512658). Colocalized with POU3F2. Colocalized with ATXN1 in nuclear inclusion bodies. Localizes to cytoplasmic stress granules (By similarity). {ECO:0000250|UniProtKB:O60828, ECO:0000269|PubMed:23512658}.
Interaction partners:
- Thioredoxin-like protein 4A
- WW domain-binding protein 11
- Ataxin-1
- WW domain-binding protein 4
- Serine/arginine repetitive matrix protein 2
- WD40 repeat-containing protein SMU1
- Transcription elongation regulator 1
- ATP-dependent RNA helicase A
- Zinc finger matrin-type protein 2
- Pre-mRNA-splicing factor 38A
Sequence:
MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRIEGLPPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVTKSAKKVRNNNADAEDKSDRNLEKVDRNHEKSDRSHEKPDRSHEKADRNHEKNDRERERNYDKVDRERDRDRERERAFDKADREEGKDRRHHRREELAPYPKNKKATSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD
Protein: Ras-related protein Rab (Q7ZW88)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046278}; Lipid-anchor {ECO:0000256|ARBA:ARBA00046278}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00046278}. Membrane {ECO:0000256|RuleBase:RU367128}; Lipid-anchor {ECO:0000256|RuleBase:RU367128}.
Interaction partners:
Sequence:
MAGGSVSECKEYLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKVLNWDSKTLVRLQLWDIAGQERFGNMTRVYYKEAVGAFIVFDITRGSTFEAVSKWKHDLDTKVKLANGNPIPSVLLANKCDQKKDGSNNSSLMDNFCKEAGFLGWFETSAKENINVDEAARFLVENILLNDKGLPYEENNGDKIKLDHQTALAESKSGCC
Protein: Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1) (P29476)
Organism: Rattus norvegicus (Rat)
Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q9Z0J4}; Peripheral membrane protein {ECO:0000255}. Cell projection, dendritic spine {ECO:0000269|PubMed:15548660}. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex (By similarity). In neurons, enriched in dendritic spines (PubMed:15548660). {ECO:0000250|UniProtKB:Q9Z0J4, ECO:0000269|PubMed:15548660}.
Interaction partners:
- Calmodulin-like protein 4
- Calmodulin-like protein 3
- Calmodulin-1
- Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
- Disks large homolog 4
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2A
- Arginase-2, mitochondrial
- Argininosuccinate lyase
Sequence:
MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQHAQGHGQGAGSVSQANGVAIDPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKATNRGGPAKAEMKDTGIQVDRDLDGKSHKAPPLGGDNDRVFNDLWGKDNVPVILNNPYSEKEQSPTSGKQSPTKNGSPSRCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKPNNSLISNDRSWKRNKFRLTYVAEAPDLTQGLSNVHKKRVSAARLLSRQNLQSPKFSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDADEVFSS
Protein: Protein sisterless A (Q9VZ09)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in sex determination and dosage compensation. Required for proper expression of Sxl in embryonic somatic cells. Also has an essential function in the yolk nuclei. Involved in endoderm migration and midgut formation.
Subcellular location: Nucleus {ECO:0000305|PubMed:8370520}.
Interaction partners:
- Protein sex-lethal
- Achaete-scute complex protein T4
- Protein deadpan
- Brahma-associated protein of 60 kDa
Sequence:
MERSHLYLPTLSYAAMGHVYAPYRGSSSPALSTASSTSSKPEQIEELVSQQLHHLKMHYADEEQRYVDQMLLENPIVVERRAPPPLKTELAMDCRGSGSGSGSGSGSDVKDAQRQRAESCRKSRYNNKIKKAKLRFRHKFVSGQLKKSAVMLDTMRDVIAQAERQLLERGYPAATLERMRATFGLEMEQ
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A (Ribophorin IA) (RPN-IA) (Ribophorin-1A) (Q9SFX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD2
- Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3A
- Dol-P-Glc:Glc
- SecY protein transport family protein
Sequence:
MKQSSVVDLLLLLLAIALLATPAFSDLVLSKVERRIDVTSQIARVTKTLKVVNSGSESVSEFALTFPKFLGNNLAYLSVAPSEGKGKSKRTLVNLSVREADQKGLPDSISVYSVALPKPLSKGDTLTLEVVAAFTNVLQPFPEKITQGEIHLVMLQESAQYLSPYAVESQSLSIKLPNARIESYTKFENTKLQGSELKYGPYKNLQSYSYSPIVVHFESKAAFAVAEKLVREIEVSHWGNVQVTENYNVVHRGAQLKGEFSRLDFQARPNPRGASAFRHLLARLPPRAHSIYYRDDIGNISTSEMKSDSKKTELLIEPRFPLFGGWKTFFTIGYGLPLTDFLFASEGKRFLNISFGSPILDLVTEKLIVQVVLPEGSKDISVTTPFAVKQSQEIKYSHLDIAGRPVVVLEKNNVVPDHNQHIQVYYKFSNINLLSEPLMLISGFFILFITCIIYTRADISISKSSPSYLAKLQWDEVLATLQEVQSIVQKCLATHDKLEASLRDLSRTGDIQTCKAARKSTDSLLKDLSKELKPLLGFLQSFPSASHISPKVEELVVKEKELQEKLMAKHTTVVEGYEKKSSGRDIENRIASQQQKIIALRQEIEDLLEFIDEI
Protein: Nucleoplasmin-2 (Q80W85)
Organism: Mus musculus (Mouse)
Function: Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.
Subcellular location: Nucleus {ECO:0000269|PubMed:12714744}. Note=Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm.
Interaction partners:
- Uncharacterized protein
Sequence:
MSRHSTSSVTETTAKNMLWGSELNQEKQTCTFRGQGEKKDSCKLLLSTICLGEKAKEEVNRVEVLSQEGRKPPITIATLKASVLPMVTVSGIELSPPVTFRLRTGSGPVFLSGLECYETSDLTWEDDEEEEEEEEEEDEDEDADISLEEIPVKQVKRVAPQKQMSIAKKKKVEKEEDETVVRPSPQDKSPWKKEKSTPRAKKPVTKK
Protein: Non-homologous end joining protein Ku (A0R3S7)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity.
Interaction partners:
- Multifunctional non-homologous end joining protein LigD
- DNA ligase C1
- DNA ligase C2
- DNA polymerase LigD, polymerase domain
- DNA ligase D polymerase domain-containing protein
- DNA ligase B
- ATP dependent DNA ligase
Sequence:
MRSIWKGSIAFGLVNVPVKVYSATEDHDIKFHQVHAKDNGRIRYKRVCEVCGEVVEYRDINKAFESDDGQMVVITDEDIATLPEERSREIEVVEFIPAEQLDPLMYDKSYFLEPDSKSSKSYVLLAKTLAETDRIAIVHFSLRNKSRLAALRVKDFSKRDVMMIHTLLWPDEIRDPDFPILDKEVQIKPAELKMAGQVVESMTDDFKPDLYHDDYQEQLRELVQAKLEGGEAFSVEEQPAELDEGTEDVSDLLAKLEASVKARKGGKSDSKDDSDSESDSKESKSDSKPAKKAPAKKAAAKKSTAKKAPAKKAAAKKS
Protein: Proline rich 10 (Q14CW7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEKRGESLDLGVRCKRGEERDRRPCWKPSRPGAARGGRGLWTVGGGGSPTETAESQQLGKPPEFWVSAHPGWLQVSCAHRASRRDASRWHPLQRFFARRGVRRPNPSVPSPLPKPPVPSAGSCEPLAPPPTSASGASRSWVTQTLAEAGAYRGCRPAPGSAAGWPRSDRRARLPRKASKPCSPALPSLAACCPQGFLRSGTKRVMCKVLGPGAGVRGTAVECSEQAGVWAHCRPQLTATFS
Protein: Cyclin mcs2 (Mitotic catastrophe suppressor 2) (P36613)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for progression through the cell cycle. Posseses kinase activity that can be detected when myelin basic protein (MBP) is provided as an exogenous substrate.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:8467814}.
Interaction partners:
- RNA polymerase II transcription factor B subunit 3
- Serine/threonine-protein kinase crk1
- General transcription and DNA repair factor IIH subunit tfb4
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH subunit tfb1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- Transcription initiation factor IIE subunit alpha
- Transcription initiation factor IIE subunit beta
- General transcription and DNA repair factor IIH subunit tfb2
- General transcription and DNA repair factor IIH subunit ssl1
Sequence:
MSADKFRDSTHYRDWIFTEEDLSKTRAKVNEKFTNIVRERMLEELSLQNKEASLEVLPPTLTVEEELELVNYYSFQLNALSSALSLPTHIRSTAILFFKRFYLINSVMEYSPKIISFTSLFLATKCNDHYISIEQFCKNMPKTTPEEVLEYEFNVCQSLKWDLYVWLPFRPLQGFLLDCQTVLPKVAVEKFYECHDLSKKFLIETLHSDIYFLHSPSIIALGAIYHTNPTICLQYIEAKKIPELQPLIISISANLKATKKFKIEKKKAQDYGRKLYFCMNPLRNKSSALYLKRKAEEESTNNNKWAKKFSTSSNVLDKNPFE
Protein: Growth hormone (Q71VP3)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MMAAGPRTSLLLAFTLLCLPWTQVVGAFPAMSLSGLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTGKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDVTPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
Protein: 5-epi-aristolochene synthase (TEAS) (EC 4.2.3.61) ((+)-2-epi-prezizaene synthase) (EC 4.2.3.226) ((-)-alpha-cedrene synthase) (EC 4.2.3.227) (Q40577)
Organism: Nicotiana tabacum (Common tobacco)
Function: Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MASAAVANYEEEIVRPVADFSPSLWGDQFLSFSIKNQVAEKYAKEIEALKEQTRNMLLATGMKLADTLNLIDTIERLGISYHFEKEIDDILDQIYNQNSNCNDLCTSALQFRLLRQHGFNISPEIFSKFQDENGKFKESLASDVLGLLNLYEASHVRTHADDILEDALAFSTIHLESAAPHLKSPLREQVTHALEQCLHKGVPRVETRFFISSIYDKEQSKNNVLLRFAKLDFNLLQMLHKQELAQVSRWWKDLDFVTTLPYARDRVVECYFWALGVYFEPQYSQARVMLVKTISMISIVDDTFDAYGTVKELEAYTDAIQRWDINEIDRLPDYMKISYKAILDLYKDYEKELSSAGRSHIVCHAIERMKEVVRNYNVESTWFIEGYTPPVSEYLSNALATTTYYYLATTSYLGMKSATEQDFEWLSKNPKILEASVIICRVIDDTATYEVEKSRGQIATGIECCMRDYGISTKEAMAKFQNMAETAWKDINEGLLRPTPVSTEFLTPILNLARIVEVTYIHNLDGYTHPEKVLKPHIINLLVDSIKI
Protein: EF-hand calcium-binding domain-containing protein, putative (Q8IKJ8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MLMLYLHILLCIFLNNPVLVTNENNFFIKILRSQEKKIENEVSLYEKLNNRILFEGSDDFSNLDKLKSLLSFQKKIDNTIRKKQKEENKLKKFQQAIKNGNNIYPVGNNPQGFEKKEREEKEQEKTYMNNVINKINEQKGNYYEPNKNINNKYTEDLTSNGLLYNKDKIKNQFNNPHQEKFIRKHEHEREHEGKNEGKNEHKNEHKNEHKNEHVHVHEHNSKNYEGNPPKNEYPNINFTNILNSIDFYKKIDLVKNYFGYNNNETLNQNMKEQKNMQNHHVENEKNNMIQANNQVDENQNNHQYNNNFHNQKNDNLKQDTKDNSSEQTYNNSNNNIEDNNHIKFFISKDIEKKKNKQNDINESVYNAIKNKNLHLRRNNIKEIFDVDDLVKNIKSFLGIKSNIHEAFENQKLIIKNCNYESFGPELCSVDEKAKEMLWKYEKKKNSAFLFIILFTLFFSLIIQNIVYFIEKKVRNSKDQFRKDLLNTAFRQISLITIINLTIWGILQTNIAEALDEVIFNDILPRHRNIDGVLHNVEPLLEVIFEKILFISMNFLICYSIFIVSIHFVTRTILKWFSESDNSDVSSVAKEVKESQRKCFRNYFFFFRNVRNSKYLAHRYDFSENVDAISIPGLDPNGYYYYEYMRASLLKYNVKLIKIPNAVILFLIFVCISLRPFYNIRLKAEVIFLNVLSLICIIGLISLFVYLYRIDTKLLPRDISKYLLNKYHIETCDKNKRDVTPYYKLLKQESVYPSALNYFFYKTTFPNKHEQLFLLWGNGPSLINFIFQTLCFCFLIILSCWIFLLRVDNITWFQLYSYGSLSICVCILVFFFILKYIIYYNVMVTKTGYLIDTKLLEQVWEYERSDNIKRISEFIDAIKIKSTLHALKEGGEIFWRQLLIKSSTVPSNIQEKMFSIWIGLDEENRGIIDSSKILKFLKSQGINLTSEHDIREFLEVFDRNNKNGLNQEEFFVLIIIVKQILVELLDINAVQSLFEEVYGIPWKSLSSIDVNSLKKILTELNLKWPHGKIRNLIDFVCENKKTKYVSAEYFIKQLINIEEVTLQPFHSASDSK