wanglab/gogpt-training-data huggingface dataset:
Protein: V-type proton ATPase subunit C (V-ATPase subunit C) (V-ATPase 42 kDa subunit) (Vacuolar proton pump subunit C) (P31412)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:14562095}; Peripheral membrane protein {ECO:0000269|PubMed:14562095}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- V-type proton ATPase subunit a, Golgi isoform
- V-type proton ATPase subunit a, vacuolar isoform
- V-type proton ATPase subunit c
- V-type proton ATPase subunit d
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit c''
- V-type proton ATPase subunit B
- V-type proton ATPase subunit H
- V-type proton ATPase subunit E
- V-type proton ATPase subunit D
Sequence:
MATALYTANDFILISLPQNAQPVTAPGSKTDSWFNETLIGGRAFVSDFKIPEFKIGSLDTLIVESEELSKVDNQIGASIGKIIEILQGLNETSTNAYRTLPINNMPVPEYLENFQWQTRKFKLDKSIKDLITLISNESSQLDADVRATYANYNSAKTNLAAAERKKTGDLSVRSLHDIVKPEDFVLNSEHLTTVLVAVPKSLKSDFEKSYETLSKNVVPASASVIAEDAEYVLFNVHLFKKNVQEFTTAAREKKFIPREFNYSEELIDQLKKEHDSAASLEQSLRVQLVRLAKTAYVDVFINWFHIKALRVYVESVLRYGLPPHFNIKIIAVPPKNLSKCKSELIDAFGFLGGNAFMKDKKGKINKQDTSLHQYASLVDTEYEPFVMYIINL
Protein: Plant/protein (Q3E9A8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mitogen-activated protein kinase kinase kinase YODA
- Protein BREAKING OF ASYMMETRY IN THE STOMATAL LINEAGE
Sequence:
MALQRSTASFRRQGSSGLIWNDRFLSGEIRNDERQEDRCNDHRDGSMAATTATVKRSASDGGCGHGGRLGELSPALDPPSPKISAVGCGFCSLFSSNGKRRSRGRRRSSGGST
Protein: Flavonol synthase 5 (F4KAS3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEEERDHNASESSLPSLSKQLESSTLGGSAVDVPVVDLSVSDEDFLVREVVKASEEWGVFQVVNHGIPTELMRQLQMVGTQFFELPDAEKETVAKEEDFEGYKKNYLGGINNWDEHLFHRLSPPSIINYKYWPKNPPQYREVTEEYTKHMKRLTEKILGWLSEGLGLQRETFTQSIGGDTAEYVLRVNFYPPTQDTELVIGAAAHSDMGAIALLIPNEVPGLQAFKDEQWLDLDYIDSAVVVIIGDQLMVWMTNGRLKNVLHRAKSDKDKLRISWPVFVAPRADMSVGPLPEFTGDENPPKFETLIYNDYIDQKIRGWALEDLPVY
Protein: DROUGHT SENSITIVE 1 (F23A5.6 protein) (Q9SAI7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DNA damage-binding protein 1a
- DNA damage-binding protein 1b
- Cullin-4
- AT3g05090/T12H1_5
- Transducin/WD40 repeat-like superfamily protein
- Protein ALTERED SEED GERMINATION 2
- Uncharacterized protein At2g34170
- Transducin/WD40 repeat-like superfamily protein
- Mediator of RNA polymerase II transcription subunit
- DNA repair protein RAD4
Sequence:
MATEYERKRLENIRRNDEMLAALNVRAKASSLLSAAKRSRDDSKSFKKKKPKPASTPTVIRMSLRTRGLNPDSAGLPDGFSDFRMGSQITHNQPSPQKQSPRLLAPIPFESAYEGYGSYTQLVDTLLGIESKSCRGKLVKGEIGVVKDENESPMVRTRSSSRVSKVSVKKEEPEDDSFSDYVNKEFSIPVKPEKIEFDLDLLTLEPQNVARVVPGRIFVVQFLPCENVKMVAAGDKLGNVGFWNLDCGNEEDNDGIYLFTPHSAPVSSIVFQQNSLSRVISSSYDGLIRLMDVEKSVFDLVYSTDEAIFSLSQRPNDEQSLYFGQDYGVFNVWDLRAGKSVFHWELHERRINSIDFNPQNPHVMATSSTDGTACLWDLRSMGAKKPKTLSTVNHSRAVHSAYFSPSGLSLATTSLDNYIGVLSGANFENTCMIYHNNTSRWISKFKAVWGWDDSYIYVGNLSKKIDVINPKLKRTVMELHNPLQRAIPCRIHCHPYNVGTLAGSTAGGQVYVWTTK
Protein: ABC transporter G family member 35 (ABC transporter ABCG.35) (AtABCG35) (Pleiotropic drug resistance protein 7) (Q7PC86)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be a general defense protein.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- ABC transporter C family member 7
Sequence:
MDYDPAHAMSRGGSMRQTISRSVSKASRNMEDIFNTSSRRTKSVNEDEEALKWASIEKLPTYNRLRTSLMPELGEDDVYGNQILNKAVDVTKLDGEERQKFIDMVFKVAEQDNERILTKLRNRIDRVGIQLPTVEVRYDHLTVKADCYTGDRSLPSLLNAVRNMGEAALGMIGIRLAKKAQLTILKDVSGIVKPSRMTLLLGPPSSGKTTLLLALAGKLDKSLDVSGEVTYNGYRLNEFVPIKTSAYISQNDLHVGIMTVKETLDFSARCQGVGTRYDLLNELARREKDAGIFPEADVDLFMKASAAQGVKSSLITDYTLKILGLDICKDTIVGDDMMRGISGGQKKRVTTGEMIVGPTKTLFMDEISTGLDSSTTFQIVKCLQQIVHLTEATVLISLLQPAPETFDLFDDIILLSEGQIVYQGPRDHILEFFESFGFKCPERKGTADFLQEVTSKKDQEQYWVDPNRPYRYIPVSEFASSFKKFHVGSKLSNELSVPYDKSKSHKAALMFDKYSIKKTELLKSCWDKEWMLMKRNSFFYVFKTVQIIIIAAITSTLYLRTEMHTRNEIDANIYVGSLLFAMIVNMFNGLAEMAMTIQRLPVFYKQRDLLFHPPWTYTLPTFLLGIPISIFESTAWMVVTYYSIGYAPDAERFFKQFLIIFLIQQMAAGIFRFIASTCRTMTIANTGGVLVLLVVFLTGGFLLPRSEIPVWWRWAYWISPLSYAFNAITVNELFAPRWMNKMSGNSTTRLGTSVLNIWDVFDDKNWYWIGVGGLLGFTVIFNGFFTLALTYLDPLGKAQAILPKEEDEEAKGKAGSNKETEMESVSAKKGMVLPFTPLAMSFDDVKYFVDMPAEMREQGVQETRLQLLKGVTSAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIEGDVRVSGFPKKQETFARISGYCEQTDIHSPQVTVRESLIFSAFLRLAKEVSKEDKLMFVDQVMELVELVDLRDAIVGLPGVTGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDELLLMKRGGHVIYSGPLGRNSHKVVEYFESFPGVPKIPEKYNPATWMLEASSLAAELKLGVDFAELYKASALCQRNKALVQELSVPPQGATDLYFATQFSQNTWGQFKSCLWKQWWTYWRSPDYNLVRFIFTLATSLMIGSVFWQIGGKRSNVQDLTMVIGAIYAAVVFVGINNCSTVQPMVAVERTVFYREKAAGMYSAIPYAISQVTCELPYVLIQTTYYSLIIYSMVGFEWKASKFLWFIFINYFSFLYWTYYGMMTVSLTPNQQVASIFASAFYGIFNLFSGFFIPRPKIPKWWVWYYWICPVAWTIYGLITSQYGDVETPIALLGGAPGLTVKQYIKDQYGFESDYMGPVAGVLVGFTVFFAFIFAFCIKTLNFQSR
Protein: Dimethylamine methyltransferase MtbB1 (DMA methyltransferase 1) (DMAMT 1) (EC 2.1.1.249) (Dimethylamine--corrinoid protein methyltransferase 1) (O93661)
Organism: Methanosarcina barkeri
Function: Catalyzes the transfer of a methyl group from dimethylamine to the corrinoid cofactor of MtbC. The major or perhaps only DMA methyltransferase expressed under inducing conditions.
Interaction partners:
Sequence:
MATEYALRMGDGKRVYLTKEKIVSEIEAGTADAADLGEIPALSANEMDKLAEILMMPGKTVSVEQGMEIPVTHDIGTIRLDGDQGNSGVGIPSSRLVGCMTHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMVIPLFYGAMPNMGLYYTPDGPFENPGDLMKAFKIQEAWESMEHAAEHLTRDTVWVMQKLFASGADGVNFDTTGAAGDGDMYGTLHAIEALRKEFPDMYIEAGMAGECVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVCNTNTSKTSAWNLARAVTFMKAAVEASPIPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPLGMPIAHIMASGMTGMRAAGDLVARMEFSKNMRIGEAKEYVAKKLGVDKMDLVDEHVMRELREELDIGIITSVPGAAKGIAAKMNIEKLLDIKINSCNLFRKQIA
Protein: GDT1 family protein (V9GY93)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365102}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365102}.
Interaction partners:
Sequence:
XVLFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPGDVETGTSITVPQKKWLHFISPIFVQALTLTFLAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTGSFSPWLILHACSDGKGHLERN
Protein: Protein phosphatase 1 regulatory subunit 14C (Kinase-enhanced PP1 inhibitor) (PKC-potentiated PP1 inhibitory protein) (Q8R4R9)
Organism: Rattus norvegicus (Rat)
Function: Inhibitor of the PP1 regulatory subunit PPP1CA.
Subcellular location: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MSVVTGGGEAAGGTSGGGARVFFQSPRGGTGGSRESSSHSGSSREDSAPVATVAAAGQVQQQQRRHQQGKVTVKYDRKELRKRLVLEEWIVEQLGQLYGCEEEEMPDVEIDIDDLLDADSEEERASKLQEALVDCYKPTEEFIRELLSRIRGMRKLSPPQKKSV
Protein: Flavin-containing monooxygenase FMO GS-OX-like 6 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 6) (Q9FWW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the conversion of methylthioalkyl glucosinolates of any chain length into methylsulfinylalkyl glucosinolates.
Interaction partners:
- Pesticidal crystal cry8Ba protein
- Protein WAVE-DAMPENED 2
- Transcription repressor OFP8
- Pentatricopeptide repeat-containing protein At1g05670
Sequence:
MTPPPNSISSRNVAVIGAGAAGLVAARELRREGHTVTIFERQKQVGGLWVCTPNVEPDLLSIDPDRTVVHSSVYQSLRTNLPRECMGYSDFPFVTRPDDESRDPRRYPDHREVMRYLQDFAKEFKIEEMIRFETEVFRVEPTAENSCKWRVQFRSSSGVSGEDIFDAVVICNGHFTEPRLAHIPGIESWPGKQIHSHNYRVSDPFKGQVVIVIGYQSSGSDISRDIAILAKEVHIAAKSDAYAKESSIYSNLHFHPTIDRVYEDGSVVFQDGKLIFADAIVHCTGYKYCFPFLETKGYVNVEDNRVGPLYKHVFPPALAPGLSFIGLPSMALQFFMFEIQSRWVASVLSGRVKLPSEEQMMEDVIAFYAKLKSLGIPKRFTHFLTDPQWTPMFEKLKPHEAVLISQSEYFNWIAEQCGCSSIERWREEQYNIAIKKDDDNFRDEWDDDDQIIQEAYRDFAKFKPSKVWST
Protein: Schlafen family member 13 (EC 3.1.-.-) (Ribonuclease S13) (RNase S13) (Schlafen-13) (Schlafen13) (rSLFN13) (Q5U311)
Organism: Rattus norvegicus (Rat)
Function: Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. Does not act on tRNA(Sec).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q68D06}.
Interaction partners:
Sequence:
MEIHPSLVVEPSYPDLIIHAGEVTLGEKDRNKMDSKKKRLEKARITEAACALLNSGGGVIVMQMSNKSEHPVEMGLDLETSLRELIPSSDLQAFIETKQQGDLFYIFVKSWSCSPKDGSTKPRICSLSSSLYCRSLTSKLPLDSKETFEFLERKKTCVKGSLTDGKGPPAKIPRLMYQNDLESNPAFEIFQSERLEYGQRLPFSESASIEFKQFSTRRAHEYIKSVIPEYISAFANTQGGYLLFGVDDESKRVLGCPKDNVDRDSLKAVVNEAISKLPVFHFCSSKEKVSYKTRVIDVFKEGNLYGYLCVIKVERFCCAVFSEAPISWMADKENGVYSLNTEKWVRMMVDIGPEAASSKQSSLDDLSKDFECQLSLSNSPPHCRPVYSKKGLEHKGDLQKRLFQVSADCFKYTPESLWRELCSQHERLENLISQQMCSFSCGLLILSRSWAVDLNLEGKQGVICDALLIAENSPPTLYTILEEQDELGQDYCTRTAFTLKQKLVNTGGYTGRVCVMTKVLCLSSQNNIETNGNSVSLIDYPRSYNLANIQEMEDLLQALVIVLLNFSSFLSDQLGCEILNLLTVQQYEILSKSLHKTRKLFVHGMPGSGKTIIAMKIMEKIKNTFHCERDSILYICENQLLRDFIRAKNVCRAVTRKTFMTPNFEVEKIQHIIVDEAQNFRTENGDWYMKAKRITQRMKTCPQIFWIFLDYFQTSHQKESGLPDFLHQYPKEELTKVVRNADKIAEFLQKISEKIRSNPPPIIPRESLNMVCEFNWSQGVSGTCKLLTSLGLEQMARYVAERCYFFLKNGYSAQDIAVLFSTEDEKDNNEDMFLREIRNRTSQIDDAYHLYMFDSIRRFSGLERSIVFGIDPRTAEKSIFHNLMLCLASRARKHLYILSKVPNPFNF
Protein: Snake venom vascular endothelial growth factor toxin HF (svVEGF) (Heparin-binding dimeric hypotensive factor) (Hypotensive factor) (HF) (VEGF-F) (P83942)
Organism: Vipera aspis aspis (Aspic viper)
Function: Snake venom VEGFs that may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension. This protein induces an increase in capillary permeability after intradermal injection, as well as a drastic hypotensive effect after intravenous injection. The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase. Also induces angiogenesis in vitro, probably through VEGF receptor (KDR/VEGFR-2) signaling.
Subcellular location: Secreted {ECO:0000269|PubMed:10512636, ECO:0000269|PubMed:14600159}.
Interaction partners:
Sequence:
QVRPFLEVHERSACQARETLVSILQEYPDEISDIFRPSCVAVLRCSGCCTDESLKCTPVGKHTVDLQIMRVNPRTQSSKMEVMKFTEHTACECRPRRKQGEPDGPKEKPR
Protein: Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8) (Q9UHI5)
Organism: Homo sapiens (Human)
Function: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29355479, ECO:0000269|PubMed:34848541}; Multi-pass membrane protein {ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541}. Basolateral cell membrane {ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:15918515}; Multi-pass membrane protein {ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541}. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. {ECO:0000269|PubMed:10574970}.
Interaction partners:
- Amino acid transporter heavy chain SLC3A2
- Large neutral amino acids transporter small subunit 3
- Large neutral amino acids transporter small subunit 1
- Monocarboxylate transporter 8
- Amino acid transporter heavy chain SLC3A1
- Large neutral amino acids transporter small subunit 4
- Neutrophil gelatinase-associated lipocalin
- Solute carrier organic anion transporter family member 1C1
Sequence:
MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP
Protein: HTH-type transcriptional regulator GalR (Galactose operon repressor) (P03024)
Organism: Escherichia coli (strain K12)
Function: Repressor of the galactose operon. Binds galactose as an inducer.
Interaction partners:
- HTH-type transcriptional regulator GalS
- UDP-glucose 4-epimerase
- Galactose-proton symporter
- Galactokinase
- DNA-binding transcriptional dual regulator CRP
Sequence:
MATIKDVARLAGVSVATVSRVINNSPKASEASRLAVHSAMESLSYHPNANARALAQQTTETVGLVVGDVSDPFFGAMVKAVEQVAYHTGNFLLIGNGYHNEQKERQAIEQLIRHRCAALVVHAKMIPDADLASLMKQMPGMVLINRILPGFENRCIALDDRYGAWLATRHLIQQGHTRIGYLCSNHSISDAEDRLQGYYDALAESGIAANDRLVTFGEPDESGGEQAMTELLGRGRNFTAVACYNDSMAAGAMGVLNDNGIDVPGEISLIGFDDVLVSRYVRPRLTTVRYPIVTMATQAAELALALADNRPLPEITNVFSPTLVRRHSVSTPSLEASHHATSD
Protein: F-box only protein 21 (O94952)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Interaction partners:
- Cullin-1
- S-phase kinase-associated protein 1
- E3 ubiquitin-protein ligase RBX1
- EP300-interacting inhibitor of differentiation 1
Sequence:
MAAAAVDSAMEVVPALAEEAAPEVAGLSCLVNLPGEVLEYILCCGSLTAADIGRVSSTCRRLRELCQSSGKVWKEQFRVRWPSLMKHYSPTDYVNWLEEYKVRQKAGLEARKIVASFSKRFFSEHVPCNGFSDIENLEGPEIFFEDELVCILNMEGRKALTWKYYAKKILYYLRQQKILNNLKAFLQQPDDYESYLEGAVYIDQYCNPLSDISLKDIQAQIDSIVELVCKTLRGINSRHPSLAFKAGESSMIMEIELQSQVLDAMNYVLYDQLKFKGNRMDYYNALNLYMHQVLIRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRWCQGAEGATLDIFDYIYIDAFGKGKQLTVKECEYLIGQHVTAALYGVVNVKKVLQRMVGNLLSLGKREGIDQSYQLLRDSLDLYLAMYPDQVQLLLLQARLYFHLGIWPEKSFCLVLKVLDILQHIQTLDPGQHGAVGYLVQHTLEHIERKKEEVGVEVKLRSDEKHRDVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHGHHQPFYNVLVEDGSCRYAAQENLEYNVEPQEISHPDVGRYFSEFTGTHYIPNAELEIRYPEDLEFVYETVQNIYSAKKENIDE
Protein: PR/SET domain 16 (H0YA13)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
IYYKVIKDIEPGEELLVHVKEGVYPLGTVPPGLDEEPTFRCDECDELFQSKLDLRRHKKYTCGSVGAALYEGLAEELKPEGLGGGSGQAHECKDCERMFPNKYSLEQHMVIHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKRFECENCVKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGGIFAPGLPLTPSPMMDKAKPSPSLNHASLGFNEYFPSRPHPGSLPFSTAPPTFPALTPGFPGIFPPSLYPRPPLLPPTSLLKSPLNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGPEEKFESRLEDSCVEKLKTRSSDMSDGSDFEDVNTTTGTDLDTTTGTGSDLDSDVDSDPDKDKGKGKSAEGQPKFGGGLAPPGAPNSVAEVPVFYSQHSFFPPPDEQLLTATGAAGDSIKAIASIAEKYFGPGFMGMQEKKLGSLPYHSAFPFQFLPNFPHSLYPFTDRALAHNLLVKAEPKSPRDALKVGGPSAECPFDLTTKPKDVKPILPMPKGPSAPASGEEQPLDLSIGSRARASQNGGGREPRKNHVYGERKLGAGEGLPQVCPARMPQQPPLHYAKPSPFFMDPIYRVEKRKVTDPVGALKEKYLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNFRSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENAPVSQHPGVLTNHLGTSASSPTSESDNHALLDEKEDSYFSEIRNFIANSEMNQASTRTEKRADMQIVDGSAQCPGLASEKQEDVEEEDDDDLEEDDEDSLAGKSQDDTVSPAPEPQAAYEDEEDEEPAASLAVGFDHTRRCAEDHEGGLLALEPMPTFGKGLDLRRAAEEAFEVKDVLNSTLDSEALKHTLCRQAKNQAYAMMLSLSEDTPLHTPSQGSLDAWLKVTGATSESGAFHPINHL
Protein: SMAD family member 3 (H0YNV1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNR
Protein: Target of EGR1 protein 1 (Q96GM8)
Organism: Homo sapiens (Human)
Function: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12562764}. Nucleus speckle {ECO:0000269|PubMed:12562764}. Note=Localizes to nuclear speckles.
Interaction partners:
- Snurportin-1
- Protein angel homolog 2
- tRNA-splicing endonuclease subunit Sen54
Sequence:
MAADSDDGAVSAPAASDGGVSKSTTSGEELVVQVPVVDVQSNNFKEMWPSLLLAIKTANFVAVDTELSGLGDRKSLLNQCIEERYKAVCHAARTRSILSLGLACFKRQPDKGEHSYLAQVFNLTLLCMEEYVIEPKSVQFLIQHGFNFNQQYAQGIPYHKGNDKGDESQSQSVRTLFLELIRARRPLVLHNGLIDLVFLYQNFYAHLPESLGTFTADLCEMFPAGIYDTKYAAEFHARFVASYLEYAFRKCERENGKQRAAGSPHLTLEFCNYPSSMRDHIDYRCCLPPATHRPHPTSICDNFSAYGWCPLGPQCPQSHDIDLIIDTDEAAAEDKRRRRRRREKRKRALLNLPGTQTSGEAKDGPPKKQVCGDSIKPEETEQEVAADETRNLPHSKQGNKNDLEMGIKAARPEIADRATSEVPGSQASPNPVPGDGLHRAGFDAFMTGYVMAYVEVSQGPQPCSSGPWLPECHNKVYLSGKAVPLTVAKSQFSRSSKAHNQKMKLTWGSS
Protein: Actin-like protein 53D (P45891)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for optimal embryo development, particularly under heat stress conditions. Also appears to have a role in negatively regulating spermatocyte cyst development. Under heat stress conditions, required for the correct organization and migration of nuclei during early embryogenesis, and therefore possibly functions by regulating embryonic actin networks during the heat stress response.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:34282725}. Note=In spermatocyte cysts, detected only during and after meiosis (PubMed:34282725). Localizes to two germline-specific actin structures: the fusome and actin cones (PubMed:34282725). First localizes to the fusome during meiosis (PubMed:34282725). Then once spermatid elongation is complete, localizes to the leading edge of the forming actin cones where it remains until the actin cones are destroyed following the completion of sperm individualization (PubMed:34282725). {ECO:0000269|PubMed:34282725}.
Interaction partners:
- Brahma associated protein 55kD
- Actin-related protein 2
- Actin-related protein 3
- Actin-related protein 8
- FI08254p1
- Actin-related protein 2/3 complex subunit
- Actin-related protein 2/3 complex subunit 4
- RuvB-like helicase 1
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 2
Sequence:
MSSEVDSNSHHAAVVIDNGSGVCKAGFSPEDTPRAVFPSIVGRPRHLNVLLDSVIGDSVIGEAAARKRGILTLKYPIEHGMVKNWDEMEMVWQHTYELLRADPMDLPALLTEAPLNPKKNREKMTEIMFEHFQVPAFYVAVQAVLSLYATGRTVGIVVDSGDGVTHTVPIYEGFALPHACVRVDLAGRDLTDYLCKLLLERGVTMGTSAEREIVREIKEKLCYVSMNYAKEMDLHGKVETYELPDGQKIVLGCERFRCPEALFQPSLLGQEVMGIHEATHHSITNCDMDLRKDMYANIVLSGGTTMFRNIEHRFLQDLTEMAPPSIRIKVNASPDRRFSVWTGGSVLASLTSFQNMWIDSLEYEEVGSAIVHRKCF
Protein: Nuclear pore complex-interacting protein family member B12 (F8W0I5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKVINTLADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTDVQQRAWRSNRRRQEGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKRKVTTKINHHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKTPPECVLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECLLTPLPPSADDNLKTPPECLLTPLPPSADDNLKTPPECLLTPLPPSAPPSAPPSADDNLKTRAECLLHPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAFHPQRMIISRHLPSVSSLPFHPQLHSQQMIISRYLLSVCGFRFHHQPMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQRAAEMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSLPEPKRRRLS
Protein: DNAation factor-related protein 2, isoform D (A0A0B4KFF6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCVCLCMFYAVPSFRFALRESRGKRPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGVPASEPVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERWYPTGVDVIKAAISAIPKIVCETIHALELHDETPSWKIMDNKGRVTVVLHWDQRQGGGSGGGGGGGGAGGGVGSMCSGLGSSNGLLSSDKYSPSKKGLSAQSSLDNKSVSSQSSQPRYASPQITVISDDGPASIYHPGGVVLPPGVVIPGGSRRLSKQGSSFDSTVGVGVGAVHVHTPECAHHAHTPSRAGSPSTTECDFHCCALHEEGRKIAVHKSVATSPIQDGSSSPQPQSAPSVMDPMLGGSGGGGSGSMQRRSSGAKGHVRFLDIAPERDSSESETENTVMEDDKTTTEKFLLLIDQLSVDQKRHLSIKDIGIILERLNSKILDVERLDRESESDDCYNWTIKATIRGDALRELGVIYNGNYYAISEHPGYKEELEENGEEVEEEEEEDEEDRI
Protein: Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein homolog) (P14404)
Organism: Mus musculus (Mouse)
Function: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:2106070}. Nucleus speckle {ECO:0000250|UniProtKB:Q03112}. Cytoplasm {ECO:0000250|UniProtKB:Q03112}.
Interaction partners:
Sequence:
MRSKGRARKLATSNECAYGNYPEIPLEEMPDADADGITSVPSLHIQEPCSPATSSESFTPKEGSPYKAPIYIPDDIPIPDEFELRESTMPGAGLGIWTKRKIEIGEKFGPYMGEQRSDLKDSSYGWEILDEFCNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEEDPHEPMAPDIHEERQHRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDLQQNLESESDLREIHGNQDCKECDRVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGTNRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASPPVKGLSSTEQSNKCQSPLLTHPQILPATQDILKALSKHPPVGDNKPVELLPERSSEERPLEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDLESDKEKCKENGKMFKDKVSPLQNLASITNKKEHNNHSVFSASVEEQSAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPSEVKKLQKGSSESPFDLTTKRKDEKPLTSGPSKPSGTPATSQDQPLDLSMGSRGRASGTKLTEPRKNHVFGEKKGSNMDTRPSSDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFSFRAPPNTLPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESAGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNMEERMNGSHFKDKKALATSQNSDLLDDEEVEDEVLLDEEDEDNDIPGKPRKELGVTRLDEEIPEDDYEEAGALEMSCKASPVRYKEEDYKSGLSALDHIRHFTDSLKMREMEENQYTDAELSSISSSHVPEELKQTLHRKSKSQAYAMMLSLSDKDSLHPTSHSSSNVWHSMARAAAESSAIQSISHV