wanglab/gogpt-training-data huggingface dataset:
Protein: Centrosomin (Protein arrow) (P54623)
Organism: Drosophila melanogaster (Fruit fly)
Function: Core component of the centrosome throughout spermatogenesis. May participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. Is a target of several homeotic genes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8582295, ECO:0000269|PubMed:9548723}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:8582295}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000269|PubMed:9548723}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:32066907}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:32066907}. Note=Localized to the centrosomes through complete nuclear cycles in mitotic and meiotic cells (PubMed:9548723). Redistributed into the cytoplasm in G2 phase cells. In post-meiotic stages, found associated with the basal body of the maturing spermatid (PubMed:9548723). In the fat body, localizes to a perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) (PubMed:32066907). {ECO:0000269|PubMed:32066907, ECO:0000269|PubMed:9548723}.
Interaction partners:
- Pericentrin-like protein, isoform F
- Spindle assembly abnormal 4
- BcDNA.LD24702
- Asterless
- Transforming acidic coiled-coil protein, isoform K
- Aurora kinase
- Centrosomal protein 135kDa, isoform B
- Spindle assembly abnormal protein 6 homolog
- Tubulin gamma-1 chain
- Centrosome-associated zinc finger protein Cp190
Sequence:
MNSNRTSSSHNSRNLKILNASFDVPRPPGGGNSPLPSQGRSVRELEEQMSALRKENFNLKLRIYFLEEGQPGARADSSTESLSKQLIDAKIEIATLRKTVDVKMELLKDAARAISHHEELQRKADIDSQAIIDELQEQIHAYQMAESGGQPVENIAKTRKMLRLESEVQRLEEELVNIEARNVAARNELEFMLAERLESLTACEGKIQELAIKNSELVERLEKETASAESSNEAIDSLKVELEACRKENQDLVTSIRTLKHDMKRQVRSMKEAANTMDVQRQSILLLEATIKRKEKSCGSMQKNVLNYEALIAKLNAELETMRQQNVYFRELSENLQQKEVRQLDRGVAIVQPMRMTADAGRFVWQSGTIVAQEPLPLERQSAAATSNVSVSAVRLSSGPPPDQTYPVNGHDRAKYGLLQLFAAKLDWISAVPLALGHLALKIILLAMRLHSCLQNVHIPLRANRDLGAQLADKICELQEAQEKLKERERIHEQACRTIQKLMQKLSSQEKEIKKLNQENEQSANKENDCAKTVISPSSSGRSMSDNEASSQEMSTNLRVRYELKINEQEEKIKQLQTEVKKKTANLQNLVNKELWEKNREVERLTKLLANQQKTLPQISEESAGEADLQQSFTEAEYMRALERNKLLQRKVDVLFQRLADDQQNSAVIGQLRLELQQARTEVETADKWRLECVDVCSVLTNRLEELAGFLNSLLKHKDVLGVLAADRRNAMRKAVDRSLDLSKSLNMTLNITATSLADQSLAQLCNLSEILYTEGDASHKTFNSHEELHAATSMAPTVENLKAENKALKKELEKRRSSEGQRKERRSLPLPSQQFDNQSESEAWSEPDRKVSLARIGLDETSNSLAAPEQAISESESEGRTCATRQDRNRNSERIAQLEEQIAQKDERMLNVQCQMVELDNRYKQEQLRCLDITQQLEQLRAINEALTADLHAIGSHEEERMVELQRQLELKNQQIDQLKLAHSTLTADSQITEMELQALQQQMQEIEQLHADSVETLQSQLQKLKLDAVQQLEEHERLHREALERDWVALTTYQEQAQQLLELQRSLDYHQENEKELKQTLVENELATRALKKQLDESTLQASKAVMERTKAYNDKLQLEKRSEELRLQLEALKEEHQKLLQKRSNSSDVSQSGYTSEEVAVPMGPPSGQATTCKQAAAAVLGQRVNTSSPDLGIESDAGRISSVEVSNAQRAMLKTVEMKTEGSASPKAKSEESTSPDSKSNVATGAATVHDCAKVDLENAELRRKLIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQILKTHNVLRNVRSNMENEL
Protein: Protein GOLVEN 1 (CLAVATA3/ESR (CLE)-related protein CLEL6) (CLE-Like protein 6) (Root meristem growth factor 6) (AtRGF6) [Cleaved into: GLV1p] (Q93VK8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Signaling peptide (root growth factor) that regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells. Also involved in the regulation of hypocotyl bending and root gravitropism in a PIN2-traffic dependent manner, thus influencing the formation of auxin gradients. Maintains the postembryonic root stem cell niche.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:22307643}. Note=The precursor is detected in the endoplasmic reticulum probably during its processing. {ECO:0000269|PubMed:22307643}.; SUBCELLULAR LOCATION: [GLV1p]: Secreted {ECO:0000305|PubMed:22307643}.
Interaction partners:
- Protein GOLVEN 2
- Protein GOLVEN 10
- Protein GOLVEN 3
- Protein GOLVEN 9
- Protein GOLVEN 11
- Protein GOLVEN 7
- Protein GOLVEN 5
- RNA polymerase II C-terminal domain phosphatase-like 5
- Protein GOLVEN 6
- Subtilisin-like protease SBT3.8
Sequence:
MSCSLRSGLVIVFCFILLLLSSNVGCASAARRLRSHKHHHHKVASLDVFNGGERRRALGGVETGEEVVVMDYPQPHRKPPIHNEKS
Protein: Cytochrome P450 734A2 (EC 1.14.-.-) (Q6Z6D6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Cytochrome P450 involved in brassinosteroids (BRs) inactivation and regulation of BRs homeostasis. Is a multifunctional and multisubstrate enzyme that controls the endogenous bioactive BR content both by direct inactivation of castasterone (CS) and by decreasing the levels of BR precursors. Catalyzes the oxidation of carbon 22 hydroxylated BR intermediates to produce C26 oxidized metabolites.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 85A1
- Nitrate reductase
- Nitrate reductase
- Nitrate reductase 1
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- 4-coumarate--CoA ligase
Sequence:
MEEDGGGGAGWGWATWRVAAVAAAAAVWVTMHVAARMADALWWRPRRLEAHFAAQGVRGPPYRFLLGSVREMVALMAEASSKPMSPPTSHNALPRVLAFYHYWRKIYGHRFLIWFGPTPRLTVAEPELIREIFLTRADAFDRYEAHPVVRQLEGDGLVSLHGDKWALHRRVLTDAFYPDNLNRLIPHVGKSVAALAAKWGAMAEAGGSGEVEVDVAEWFQAVTEEAITRATFGRSYDDGRVVFAMQGQLMAFASEAFRKVLVPGYRFLPTKKNRLSWRLDREIRRSLMRLIGRRSDEAEQGEKADDGSFRDLLGLMINAGAAAATRGNAGGEKNSPAAAIPVEDMLEECKTFFFAGKQTTTNLLTWATVLLAMHPDWQERARREVFDVCGAGELPSKEHLPKLKTLGMIMNETLRLYPPAVATIRRAKVDVQLSDGCMIPRDMELLVPIMAIHHDTRYWGPDASQFNPARFANGASKAAKHPLAFIPFGLGSRMCVGQNLARLEAKLTMAILLQRFEIRTSPNYVHAPTVLMLLYPQYGAPLIFRPLSSHPPDSTGP
Protein: Zinc-binding dehydrogenase family protein (F4IBH8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Glycosyl hydrolase family 10 protein
- At4g33840/F17I5_30
- Glycosyl hydrolase family 10 protein
- Glycosyl hydrolase family 10 protein
- At4g38650
Sequence:
MGEVSVVENKKVILKNYVDGIPTETDMEVKLGETIELKAPKGSSCFLVKNLYLSCDPYMRGRMRDFHGSYLPPFVPGQRIEGFGLARVIDSDDTNYKPGDIVSGIIGWEEYSLLRSSDNLQLRNIQLDDDIPLSYHLGLLGMAGFTAYAGFNEICCPKKGDSVFVSAACGAVGQLVGQLAKLHGCYVVGSAGSKQKVEILKNELGYDEAFNYKEEADLDTALKRYFPEGIDIYFDNVGGSMLDAALLNMKVRGRIALCGMVSLQSLSTSSQGIKNLYSAIYKRLRLEGFLQSDYLHIFPQFLENVKRYYKEGKIVYVEDISEGLDLAPAALVGLFSGKNIGKQVVRVAKE
Protein: Putative O-antigen polymerase (P37748)
Organism: Escherichia coli (strain K12)
Function: May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Putative O-antigen transporter
- Beta-1,6-galactofuranosyltransferase WbbI
- Putative glycosyltransferase WbbK
- dTDP-4-dehydrorhamnose 3,5-epimerase
- UDP-galactopyranose mutase
- Putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ
- Glucose-1-phosphate thymidylyltransferase 1
- Lipopolysaccharide biosynthesis protein WzxC
- Probable ECA polymerase
- Lipid III flippase
Sequence:
MIYLVISVFLITAFICLYLKKDIFYPAVCVNIIFALVLLGYEITSDIYAFQLNDATLIFLLCNVLTFTLSCLLTESVLDLNIRKVNNAIYSIPSKKVHNVGLLVISFSMIYICMRLSNYQFGTSLLSYMNLIRDADVEDTSRNFSAYMQPIILTTFALFIWSKKFTNTKVSKTFTLLVFIVFIFAIILNTGKQIVFMVIISYAFIVGVNRVKHYVYLITAVGVLFSLYMLFLRGLPGGMAYYLSMYLVSPIIAFQEFYFQQVSNSASSHVFWFFERLMGLLTGGVSMSLHKEFVWVGLPTNVYTAFSDYVYISAELSYLMMVIHGCISGVLWRLSRNYISVKIFYSYFIYTFSFIFYHESFMTNISSWIQITLCIIVFSQFLKAQKIK
Protein: G protein pathway suppressor 1 (A8K070)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRDSSAPSSASSSVTDLYCTPHSSRSDLVLPGTAGDFSLSASLSACTLLYEGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAERGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM
Protein: Transmembrane protein 53 (Nuclear envelope transmembrane protein 4) (Q9D0Z3)
Organism: Mus musculus (Mouse)
Function: Negatively regulates bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD1/5/9 proteins.
Subcellular location: Nucleus outer membrane {ECO:0000269|PubMed:12958361, ECO:0000269|PubMed:20091084}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Aspartate beta-hydroxylase domain-containing protein 2
- ERI1 exoribonuclease 3
- Acyl-CoA-binding domain-containing protein 6
Sequence:
MASAELDYSIEIPDQPCWSQKNRQGGKEAGKQQPVVILLGWGGCRDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLGIPSLRVIAQKLLELLFDYEIEREPLLFHVFSNAGVMLYRYVLELLQTHQRFRHLHVVGTIFDSGPGDSNLIGALRALATILERRPAVLRLLLLAAFALVVILFHFLLAPFTALFHTHFYDRLQDSGSCWPELYLYSRADKVVSARDVERMVEARLAHQVMVRGVDFVSSAHVSHLRDYPTYYTSLCVDFMHNCVQC
Protein: 5'-tyrosyl-DNA phosphodiesterase (5'-Tyr-DNA phosphodiesterase) (EC 3.1.4.-) (Q9XWG3)
Organism: Caenorhabditis elegans
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O95551}. Nucleus, PML body {ECO:0000250|UniProtKB:O95551}.
Interaction partners:
- Probable tyrosyl-DNA phosphodiesterase
- DNA topoisomerase 2 top-2
- Ubiquitin-ribosomal protein eL40 fusion protein
- Small ubiquitin-related modifier
- Transcription factor ets-4
- Max-like protein 1
Sequence:
MSNSDDEIQEIEAKRQKMSQEDSEVEIEILDEPEQGKLKNSSMSDEQKLHEFAIITATDEAFAQSILQDVDWDLKKALDVFYGSEAFAEARSAAVMGASSSMASSGAAVMTAEDLKGFEVSVMSWNIDGLDGRSLLTRMKAVAHIVKNVNPDILFLQEVVDRDLAPIDKLQSLYKIYYSNKGCQYYTAILVSKMFDVEKHDVIHFQNSGMYRTLQILEGSIGGLKVFLLNTHLESTREHRPQRCAQFGFCMDKVREIIAQNPGALVFFGGDLNLRDEEVSRVPDGVKDAWEAAGSDNKTKFTWDTFKNDNKQGFHGAKMRFDRLYWSGPLDKVKFTLEGRQRIRSCLCFPSDHWAINATFFA
Protein: Homer protein homolog 3 (Homer-3) (Q9NSC5)
Organism: Homo sapiens (Human)
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Subcellular location: Cytoplasm {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
Interaction partners:
- Homer protein homolog 1
- Metabotropic glutamate receptor 1
- Homer protein homolog 2
- SH3 and multiple ankyrin repeat domains protein 1
- Disks large-associated protein 1
- Metabotropic glutamate receptor 5
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- SH3 and multiple ankyrin repeat domains protein 3
- Disks large homolog 4
- SH3 and multiple ankyrin repeat domains protein 2
Sequence:
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAAP
Protein: Auxin-responsive protein IAA33 (Indoleacetic acid-induced protein 33) (Q9FKM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Auxin-responsive protein IAA32
- Auxin-responsive protein IAA34
- Auxin response factor 10
- Auxin-responsive protein IAA20
- Auxin response factor 20
- Auxin-responsive protein IAA31
- Auxin-responsive protein IAA6
- Auxin response factor 5
- Auxin-responsive protein IAA30
- Auxin response factor 19
Sequence:
MNSFEPQSQDSLQRRFHQDNSTTQQPRDTTTPFIPKPASKNHNNSNSSSGAAGRSFQGFGLNVEDDLVSSVVPPVTVVLEGRSICQRISLDKHGSYQSLASALRQMFVDGADSTDDLDLSNAIPGHLIAYEDMENDLLLAGDLTWKDFVRVAKRIRILPVKGNTRQVKRNE
Protein: Probable galacturonosyltransferase-like 1 (EC 2.4.1.-) (Protein GAOLAOZHUANGREN 1) (Protein PARVUS) (Q9LN68)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the biosynthesis of the tetrasaccharide primer sequence, beta-D-Xyl-(1,3)-alpha-l-Rha-(1,2)-alpha-D-GalA-(1,4)-D-Xyl, located at the reducing end of glucuronoxylan. Might catalyze the transfer of the reducing Xyl residue onto a protein acceptor in the endoplasmic reticulum, which is then transported to the Golgi where the subsequent additions of sugar residues take place.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17991630}; Single-pass type II membrane protein {ECO:0000269|PubMed:17991630}.
Interaction partners:
- Probable glucuronoxylan glucuronosyltransferase IRX7
- Beta-1,4-xylosyltransferase IRX9
- Beta-1,4-xylosyltransferase IRX14
- Probable beta-1,4-xylosyltransferase IRX10
- Probable beta-1,4-xylosyltransferase IRX10L
- Probable beta-1,4-xylosyltransferase IRX14H
- Probable glucuronoxylan glucuronosyltransferase F8H
- UDP-glucuronate:xylan alpha-glucuronosyltransferase 1
- Protein IRREGULAR XYLEM 15
- Probable beta-1,4-xylosyltransferase IRX9H
Sequence:
MSQHLLLLILLSLLLLHKPISATTIIQKFKEAPQFYNSADCPLIDDSESDDDVVAKPIFCSRRAVHVAMTLDAAYIRGSVAAVLSVLQHSSCPENIVFHFVASASADASSLRATISSSFPYLDFTVYVFNVSSVSRLISSSIRSALDCPLNYARSYLADLLPPCVRRVVYLDSDLILVDDIAKLAATDLGRDSVLAAPEYCNANFTSYFTSTFWSNPTLSLTFADRKACYFNTGVMVIDLSRWREGAYTSRIEEWMAMQKRMRIYELGSLPPFLLVFAGLIKPVNHRWNQHGLGGDNFRGLCRDLHPGPVSLLHWSGKGKPWARLDAGRPCPLDALWAPYDLLQTPFALDS
Protein: Mitosis inducer protein kinase cdr2 (EC 2.7.11.1) (P87050)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a mitotic inducer. In G2 it negatively regulates wee1, a mitotic inhibitor. Also has a role in cytokinesis where it required for proper septum formation.
Interaction partners:
- DYRK-family kinase pom1
- Mitosis inhibitor protein kinase wee1
- Anillin-related medial ring protein mid1
- Mitosis inducer protein kinase cdr1
- Mitosis inducer protein blt1
- M-phase inducer phosphatase
- Rho guanine nucleotide exchange factor gef2
- Kinesin-like protein 8
- Cyclin-dependent kinase 1
- Cell division control protein 15
Sequence:
MSTISEVGPWELGLSLGSGGPNSSRLAKHRETGQLAVVKPIVGWSELTSSQQARIEGELVLLRLIEHPNVLQLIDVISAQEQLFVVVEYMPGGELFDCMLRKGSFTEQDTAKFLWQILCGLEYCHKLHICHRDLKPENLYLDAHGSIKIGEFGMASIQQPGKLLQTSCGSPHYASPEIIMGRSYDGCASDIWSCGIIFFALLTGKLPFDDDNIRSLLLKVCQGQFEMPSNISPQAQHLLYRMLDVDSSTRITMEQIREHPFLSCFVHPNISIPIISAPIQPIDPLIVQHLSLVFRCSDDPMPLYEKLASQSPLVEKTLYTLLSRHLHPPSSAAVDRNRAVVDDLLGTAASNGQQMDEEEIEQAINIPTLAPYPISYAAESVPRPATSASPFLTPVTTSGTFNYSFNATNPQSILQRPATTSSAVPQLPKSVTPGLAYPHDSSMLSSNYRPPSALSPRNFNVSINDPEVQLSRRATSLDMSNDFRMNENDPSIVGNLAASNFPTGMGPPRKRVTSRMSEHTGNRVVSFPRGSAFNPRVTRFNVGNEQFSNNIDNNNYNQPYANATMNNSRRLRTPSGERSMRADLSQSPASYDSLNVPKHRRRQSLFSPSSTKKKLSGSPFQPKRSFLRRLFSSEPSCKCVYASLVASELEHEILEVLRRWQLLGIGIADIIYDSVSASISARIKRQNSLNLKPVRFRISVLAEFFGSQAVFVLESGSSTTFDHLATEFQLIFEDKGFLDNLELSYFQASASRPVSRMSVSSSPFAVFRQRQSVQS
Protein: Coiled-coil domain-containing protein 40 (Q4G0X9)
Organism: Homo sapiens (Human)
Function: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8BI79}. Cell projection, cilium {ECO:0000269|PubMed:27120127}. Note=Localizes to cytoplasm and motile cilium. {ECO:0000250|UniProtKB:Q8BI79}.
Interaction partners:
- Coiled-coil domain-containing protein 39
- Outer dynein arm-docking complex subunit 1
- Dynein regulatory complex subunit 2
- Dynein regulatory complex protein 1
- Radial spoke head protein 4 homolog A
- Dynein axonemal heavy chain 5
- Dynein axonemal assembly factor 1
- Dynein axonemal intermediate chain 2
- Dynein axonemal assembly factor 19
- Dynein axonemal assembly factor 11
Sequence:
MAEPGGAAGRSHPEDGSASEGEKEGNNESHMVSPPEKDDGQKGEEAVGSTEHPEEVTTQAEAAIEEGEVETEGEAAVEGEEEAVSYGDAESEEEYYYTETSSPEGQISAADTTYPYFSPPQELPGEEAYDSVSGEAGLQGFQQEATGPPESRERRVTSPEPSHGVLGPSEQMGQVTSGPAVGRLTGSTEEPQGQVLPMGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKLESPGPS
Protein: Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (Q7ZTA3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361244}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361244}.
Interaction partners:
- Pro-opiomelanocortin protein
- Agouti-signaling protein
- Proopiomelanocortin b.
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
- Oculocutaneous albinism II.
- Melanocyte-inducing transcription factor b
- Tyrosinase.
- Melanocyte inducing transcription factor a isoform 1
- Dopachrome tautomerase.
Sequence:
MNDSSRHHFSMKHMDYMYNADNNITLNSNSTASDINVTGIAQIMIPQELFLMLGLISLVENILVVVAIIKNRNLHSPMYYFICCLAVADMLVSVSNVVETLFMLLTEHGLLLVTAKMLQHLDNVIDIMICSSVVSSLSFLCTIAADRYITIFYALRYHSIMTTQRAVGIILVVWLASITSSSLFIVYHTDNAVIACLVTFFGVTLVFTAVLYLHMFILAHVHSRRITALHKSRRQTTSMKGAITLTILLGVFILCWGPFFLHLILILTCPTNPYCKCYFSHFNLFLILIICNSLIDPLIYAYRSQELRKTLKELIFCSWCFAV
Protein: CCR4-NOT core subunit (A0A1D8PQD2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- CCR4-NOT core ubiquitin-protein ligase subunit
- CCR4-NOT core subunit
- General negative regulator of transcription subunit
- CCR4-NOT core DEDD family RNase subunit
- CCR4-NOT core subunit
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- General negative regulator of transcription subunit 3
- ATP-dependent RNA helicase DHH1
- CCR4-NOT core subunit
- Coupling of ubiquitin conjugation to ER degradation protein 1
Sequence:
MSFKELLIEIGPENLLPEKLLPSLLQIKPNEIDQGIALILAEILIPGSQGLSQGLTFASSLPGSNAKGAQLQTCFKSIENSGKFNVNWYEVFNHVHQYLFDSSQRDIQPSVGSITQFLSSLDFKQEPIDIFLNYEWWFNKTLLYILHSSDASQGGYDISLSPNLAYCFEEDKTTPQTRRNILKFINVGKLEIQVITKIQQQQQQQQQQQQQQHQLSEQDKKLNAFLNQLFEHDYRVFPEYILAAALTVVEKSQFINDLIDTLFYLLVDSASPSLPKVVRLLKESGLAAIKLADYYKSRKTIDAADKVLTLASSFGLTQEILDIFWAFDSKIAIKILVESSLFGYDYKSVIDSKLKDPQVKTSIYQALCEALDERAQKDYERGQQVQQAQQLQQQQALPPHQVLKIPTVYYLLEKIKSSNGVVDAKTLRNLQLLLLTTYPRLINFGNGHDEAILANEEKSPFFPPSVEMEMKAYYSKMYNKELEIKEIVDMLTQMKASDDLHSQDVFACMIHSLLDEYKFFSEYPLSALASTSLLFGALLEKDLIQGTTLTVALNFIWESCNQPQDSHLFKFAVQSLYNFKSRLHEYPIYCKHLLECRSLSAHAKMYQIVKDAANGIPCTTGAAPTQTNTPDVGPKYQSINYVDRTIGYATQEEPPESIRDKLLFSVNNMTGENLRLSEIQEVLTESYFAWFSDYLVSDRAKAEPNNHELYSKLVKSLANPIFFEYILNVSLKEVDYIIRNFKDSRSERNQLKNLGAWLGRITLANDKPLRRDYIALKFLLVEAYDFNSLPLILPFVCKILDQAQYSKVFKPPNPWVVGVMKVLAELYECADLKLQLKFEIEVLLNSFNMKIKDIEQSTIIRNHNPEPTALARMFGISSQSVNLANEMTRLSLEGSQLGNNIQAPFPQQIIESKQFPGISQPQMQNVLQQQQQQQQQQQQQQLPPQQQLPGQLPPQQQAEPALDTSFSTLIGNSIFTQHANLRRAFQASLSRAVRECTPHICNKVVETVVTTTKALITKDFATERDIEKFRNSYQKLALSLSHAMVSCNGRKALVETIEATMLQLLGNNPNEVPLAELNSAIQANVGLCVDIVDVLVGESILDIIEARMQTEVFLREHHTATAPNEPFIAEGASDYSLRLPNPLGLALTGLSAQQLKIYEHFGEARVDQIVPPPGSTGITQQQTQSLAPLQQQQQQQQQQQPVSTVVAAAPAPAPPQQQQQSKERIAQAQGVPDDIVSFEQLFTAITANCDKAVQLVSEVTETKLADLPPNHSIMAALTQALVIAQTNAIKYPELLLKAAQYAVNCLFTQTHENPMSNEIYVVILDKLCEYSPSTAKDVIWWLVHSSDQRKFNMPVMLSLLKVQLIQPIKLDLSIGKLIKETNNPVVVKFAASLLTNIFTSEEMRPIALRSEFANTLDALSKYQANDQSEEDRQAKEATSTLFKLLSEAAPASNQLFAQLGYIFAEWVRLLTHGDDATNELQIEFVKGLIQSGILNNPEYVKTFFKAAIEISITSFATEHELRSRTQHETYFAVDTLAMLIVRIVLLVEDSKQAIDYLKKVLGIIILNLINDHETSKANWNERAYFRFFSSLLSTWCDASVLDEEVTVNLDVEFYNYLGELFNALQPIVLPGFTFAWISLISHRMYLPKLLELPERKGYATLVKLLSSALKFQQIYGNNKQSSRRQQELEQEQEQEQKDEKDAKDAKEQNQEQEQEQENSQQGPEVINVTYKAINRIFIGILHDFPEFLVECHYQLVTSIPRGYIQLRNIVLSATPKDIHVPDPFTQGLKVERLPEINESPVVFYKPIEDLSKVGLKKPVENFLRIPAPGLMRTIYNGLKLNQPKEVNELGYEETINFNIKLINALVLHVGISSVADRLPNNRGFNTKSSQVALLVDLMNYGNTEFKYHLINAIANQLRYPNSHTHWFIGIILHFFSNNNIWNSNGNKLVVQEIITRVLLERRISNKPHPWGLTILFTELVKNGDYGFFELPFVKDSVEEVKNIFNVLSINVKGSTP
Protein: pH-response regulator protein palH/RIM21 (Q59YK4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- pH-response regulator protein palI/RIM9
- pH-response regulator protein palF/RIM8
- Calpain-like protease palB/RIM13
- pH-response regulator protein palA/RIM20
- pH-response transcription factor pacC/RIM101
- Dfg16p
- Vacuolar-sorting protein SNF7
- Ubiquitin-binding ESCRT-I subunit protein
Sequence:
MYWKNAWWVGTVYSSCEPIELPEGMLISKQYETYPITTVSKAIYKQMCYRNCIPVLNTNVGFVIDTFAKPLPIVSQSWREFTKDSLRGSFAYSVVSIIYAIAVSAVIIWFLTIFVLTNYTIKPSWLLKTSTILSTVYILVVVIKSILILHGQQRDGYLHGAKLLSELNDYNPIQIIDLIVVLLLQINQVQIIMRIFQRQKDKRMALLIGIVATLASQVIWAIAQFYTPADANEASDILPAFIYLVRIAMALCYAAIITVFFISKIQIILANKKIWLLTLLTFILIYSPVAFFVADVSNAFVYELSEIFSVVNYVIGVVIPWEWCNKFNLIMKAKEKEGVLGRRFYEDELYELDRFELFVEEQMPEDEDNGDTHSDSPGNELNGGAHHNSQEQSDRLIGSNSPTNKPHNGNNTDPTSRFRQLLTNTKDAFLTLTDNIIAAGFAIPRSVSVSTQSLTGRYRNNSTARTEYTKEVVPDFSPEMFLQPEGSSHITETLSEQNAAPSTTNSNHRRRNVYVYSRKEVILDVSSDE
Protein: Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-) (Sialyltransferase 8E) (SIAT8-E) (Sialyltransferase St8Sia V) (SATV) (ST8SiaV) (Q6ZXC8)
Organism: Rattus norvegicus (Rat)
Function: Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:1606358}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYSKSYIKRYFEFYKEPLEFNSTRCLELRQEILEVKVLSMVKQSELFERWKSLQICKWAMDASEASLFKSTLSRCCNAPNFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPKPGFHAMPSEIFTFLRMHSRGILRVHTGTCNCC