wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) (Q16656)
Organism: Homo sapiens (Human)
Function: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Subcellular location: Nucleus.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Peroxisome proliferator-activated receptor gamma coactivator 1-beta
- Transcription factor A, mitochondrial
- Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
- Forkhead box protein O3
- Cytochrome c
- GA-binding protein alpha chain
- GA-binding protein subunit beta-1
- Steroid hormone receptor ERR1
- Host cell factor 1
Sequence:
MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANGLVQIPVSMYQTVVTSLAQGNGPVQVAMAPVTTRISDSAVTMDGQAVEVVTLEQ
Protein: DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (RNA polymerase I subunit B) (RPA135) (P20028)
Organism: Drosophila melanogaster (Fruit fly)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P22138}.
Interaction partners:
- DNA-directed RNA polymerase I subunit RPA1
- RNA polymerase I subunit F
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- LD14127p
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
Sequence:
MLEEMQQMKTIPVLTNSRPEFKQIPKKLSRHLANLGGPHVDSFDEMLTVGLDNSAKHMIPNHWLSPAGEKISMKVESIWIAKPKVPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSVNGVQKTPINMDLGEVPIMLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEKIVRMLIMTRRNHPICVKRSSWKDRGQNFSDLGMLVQTVREDESSLSNVVHYLNNGTAKFMFSHVKRLSYVPVCLILKCLMDYTDEEIYNRLVQGYESDQYYVSCVQAMLREVQNENVYTHAQCKSFIGNLFRARFPEVPEWQPDDDVTDFILRERVMIHLDTYEDKFQLIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHLYQKYLSERVESWVSQVRRCLQKKLTSPDALVTSAVMTQCMRQAGGVGRAIESFLATGNIASRTGLGLMQNSGLVIMAENINRMRYMSHFRAIHRGSYFTTMRTTEARQLLPDAWGFICPVHTPDGTPCGLLNHLTLTCEISMRPDPKLVKAIPKHLIDMGMMPLSNRRYLGEKLYVVFLDGKHLGHIHQSEAEKIVDELRYGKIFGTLPQMMEIGFIPFKKNGQFPGLYIATGPARMMRPVWNLKWKRVEYIGTLEQLYMEIAIDAKEMYPDFTTHLELAKTHFMSNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAANKLYRLQTPGTPLFRPVHYDNIQLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIYKTKFLTLDKKSSYFARHPHMPELIKHLDTDGLPHPGSKLSYGSPLYCYFDGEVATYKVVKMDEKEDCIVESIRQLGSFDLSPKKMVAITLRVPRPATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETMAGKGAAIHGNVYDATPFRFSEENTAIDYFGKMLEAGGYNYYGTERLYSGVDGREMTADIFFGVVHYQRLRHMVFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFLLQDRLFHNSDKTHTLVCHKCGSILAPLQRIVKRNETGGLSSQPDTCRLCGDNSSVSMIEIPFSFKYLVTELSSVNINARFKLNEI
Protein: Vigilin (H7C0A4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
XAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKS
Protein: chitinase (EC 3.2.1.14) (Q4WEM4)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
Sequence:
MSLLAQLLALTAAAASLERVYAKLDLSSSSNVAVYWGQNSFRGTGDLAQQRLSYYCDGESFMFGYFQVNVLMETSLDPKIDVFELAFLIRINGQGGVPEVNFSNANDNCTLFKDTNLLKCPQIGEDITTCQKKGKTILLSIGGATYSEGGFSSEPAAKAGAELVWQTFGPPSINATAHRPFGNASVDGFDFDFEASVSNVAPFANRLRELMDADHRRDYFLTAAPQCPYPDAADKDILNGPVSVDAVFVQFYNNWCGLNSFEAGESKQNSFNFEVWDNWAKTVSLNKKAKVFLGVPANTGAAGSGYVPVDTLKPIIEYSKKFSSFGGVMMWDVTQAYGNTGFLDGVAQALGKTASHVRRSCRYRPYGWF
Protein: Gap junction beta-5 protein (Connexin-31.1) (Cx31.1) (P28232)
Organism: Rattus norvegicus (Rat)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Interaction partners:
Sequence:
MNWSVFEGLLSGVNKYSTAFGRIWLSLVFVFRVLVYLVTAERVWGDDQKDFDCNTRQPGCTNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRKAREKKYQQEVGKGYLYPNPGKKRGGLWWTYVCSLLFKATIDIIFLYLFHAFYPRYTLPSMVKCHSAPCPNTVDCFIAKPSEKNIFIVFMLVTAIVCILLNLVELLYLVIKRCSECAPAKRPPTAHAKNDPNWANPSSKEKDFLSSDLIFLGSDTHPPLLPDRPRAHVKKTIL
Protein: Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) (Q9ERE3)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:21865597}. Early endosome {ECO:0000269|PubMed:21865597}. Recycling endosome {ECO:0000250}. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Colocalizes with SLC9A3/NHE3 in the recycling endosomes (By similarity). Localized in vesicle-like structures and in the early endosome. {ECO:0000250}.
Interaction partners:
- 3-phosphoinositide-dependent protein kinase 1
- Forkhead box protein O3
- Forkhead box protein O1
- Forkhead box protein O4
- Forkhead box protein O6
- Serine/threonine-protein kinase Sgk1
- Serine/threonine-protein kinase Sgk2
- E3 ubiquitin-protein ligase NEDD4-like
Sequence:
MQRDCIMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNSLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPRHQSDPSEDEDERSTSKPHSTSRNINLGPTGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSILEELLEKNRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVAGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
Protein: LD31969p (Q7K4M9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Late endosome {ECO:0000256|ARBA:ARBA00004603}.
Interaction partners:
- FI04476p
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MRSVEEIKAEYPLHWHIWHNELEQLQAAIDQNDKEKIDPRGRTPLMLAVRLANLPCVKCLLAAKCNATYEYEGWSIVQEAVCTGDVDILTAIIEVRDLQRHVQRVTHVPKLLQHLLDAPDFYIEMKWEFTSWVPLMSRLCPSDTYKVYKRGANVRIDTTLLGFDNNTWQRGNRSYIFKGAKETATMIEIDHDTNEVMVEEMSSDIGDIVAIPPALGTVRARLNAPVITNNIEMDKISFERNKCGIWGWRSEKSEMINGYNCKVYGASNVEFVTKTRMDHLSEEQIKNKTARTPLHSLLGIADEDYVSPADAAAALKDRTPSPRLEEASNAGVENGGRNSPAPGNQSNGSSAGASGTSTPKSSVTPEEYFTQEFDLHGRDVGGPKNLSTKVQRFRANLWLAEEHPIRLQEQVLPILDLMSTMASPHVSKLRDFITMQLPAGFPVKVEIPLFHVLNACITFGNVFALTTPVDHVATLQEQDRVTCLVDDRCFDIPAHYTNRGSDVRRQIPLDEDDMLQYAIEQSLVETSGACGVDARDDDKVDIWEVLRGQNVVGSDLLPEDDEQLQRVLQESLLGAHANLQSGSPASDEDDDGGFRYVDPDLAMAMRLSQQEQRKFELERQQEQEMIEQALKLSLQEH
Protein: EG:EG0007.12 protein (Q7K764)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNNEQTPSSSDTPADRVASGGAAAKLPTIIPDTPIVSIAAGTMSESTTTTTVTKTTPTPFPQEQLMTMMSDHVAKADAQLDEACRNQGAKDEDSQGAAPVAANHVATSGSSSRGNDPKKSSSPSNSHSSGNHAATADAAKGSAAEAAAGDTSFSQVFAMLKDSPSAELSRPNRRVLQYGATAKGKTQDDQNVGKRQKKKKTKYDTWEDSDFNDLDDASLKKLLEEAYWYRNPGDRKNKSERFLQMLKKAEYDEEISYRAIKSCLTINPSALTSSAATGSSGGSSSSAGHNSSYNSTNHRSTDPGQRHKQGGSLQDLVEAAHRSELATTSAAAAAAATAAATQRFNCDYQLSGRSNRRQQQQQQQHNQNATSSASASKKIKNLNVSGRQREGGSLPSSVNFEPASSAMEAKQNKQQAQPSTEAAGGSFSGSVGNKHHHRSSTGSCSSLITQSRDTEANNQFDLDMDDATGVGASAVVGASGDQDDNMLEQLDPQNPSMKFLIDALNDTPLEARYTGAGKKFLIDDRLHFSVLELSARRKLQQQAQYLAALTGQFGLGLEEEKRKVEAGYVSLNDNYTACSSVYGGGAGSPAAVEGSKPSTSSSAVSGGSNCGASSDALSSDLRPAKIGRMVPAAAAVAAAPMGGKTTTRQLDENGNALGDGFGGSAASGSSGASGASAAASSSNGNGNANQFTALITPTNSVSTLLSTGTNTTTTAMAAAAVAASYSQLQQAPVGGAAGTVSGIGIGMQQPTKQKTKKKSQQERNTTTVDVESVAGYRGNDPVEQLVKYIENDVNGGGNSAAGQRKKERKKQNKLKKSNSLEELRTCSKMEVDDLKRQSATTEMMRHKKGTNNASSGGSSSTASGSSNSGKHNSASVADINKNCNKEQQQQSTPTVQVRNSNNPGTQQRKGERRSWGTEELQYLGDHQEISAAWSELETVGQKELPLRCPPWRACPNWMP
Protein: D-3-phosphoglycerate dehydrogenase 2 (3-PGDH 2) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (P40510)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
Interaction partners:
- D-3-phosphoglycerate dehydrogenase 1
- Phosphoserine aminotransferase
- Probable ATP-dependent kinase TDA10
- Serine hydroxymethyltransferase, cytosolic
- Alanine--glyoxylate aminotransferase 1
- Phosphoglycerate mutase 1
- Phosphoglycerate mutase 3
- Phosphoglycerate mutase 2
- Aminomethyltransferase, mitochondrial
- Phosphoserine phosphatase
Sequence:
MSYSAADNLQDSFQRAMNFSGSPGAVSTSPTQSFMNTLPRRVSITKQPKALKPFSTGDMNILLLENVNATAIKIFKDQGYQVEFHKSSLPEDELIEKIKDVHAIGIRSKTRLTEKILQHARNLVCIGCFCIGTNQVDLKYAASKGIAVFNSPFSNSRSVAELVIGEIISLARQLGDRSIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGTARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQSSIGIEVATALSKYINEGNSVGSVNFPEVSLKSLDYDQENTVRVLYIHRNVPGVLKTVNDILSDHNIEKQFSDSHGEIAYLMADISSVNQSEIKDIYEKLNQTSAKVSIRLLY
Protein: Rifin (Q8IJ05)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKLQYSKILLFSLPLNILVSSSYAHNKNKSYIAPHIPTTTTRVLSECNLYIPKYDNDADMKSVKENFDRQTSQRFEEYEERMIKNRQKRKEQRDKNIQKIIHKDKMEKNLAEKVEIGCLRCGCALGGVAASVGLFGGLGTYGWKIAATATAMELAKEAAEQAGAAAAADAGKNAVIAGLKELGVQNIAGQPLVSYLTATNYHNATFISSAINNQYSPSSCIFVSSGTRSGPVARETFCTWVMQKSTAAANVQRSSVSFNDLIIKTIENIVTDAKKAAGEATEKAIEEVIQRSTAAVESTYASCQSAIIASVVAIVVIALVMIIIYLVLRYRRKKKMNKKAQYTELLNQ
Protein: Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) (A1ZA22)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
- Eukaryotic translation initiation factor 2 subunit 1
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit epsilon
- Eukaryotic translation initiation factor 2 subunit 3
- Translation initiation factor eIF2B subunit delta
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 5
- Guanine nucleotide exchange factor MSS4 homolog
Sequence:
MTEFQAVVFAAGRGTRLPEVLGDAPKCLLPVGPYPLIWYPLNLLQQHNFTEVIVVVLEQEKLEIQSALENTPLKLRLDYATIPSDGDFGTADSLRYIYDKIKSDFLVVSCDLVSNVSLYPLINKFREHDAALAMLLFPSGFESDVVMPGPKSKHKPERDLIGIHAATQRLAFVSAASDCEETLNIQRHLLKNRGRLDVYSRLVDAHVYVLKKWVIDYLRRKENISTFKGEFLPHLIKKQHSKRPPKTVQDTTSEVGVVTKNEDHVLHYVGHTILDQKITQTSLFNQSLSQSPYHGDIVRCYGIQAPRDAIGVRVNNTLSFLAINRKLASIWNNLCGEKHPLISPGAVVKSTQTKEIIAADNAKLSEKTSLNFSVFGPNCIISPKNIVANSLIMSNAIVEEGCNIDNCIIGHRAQVKSGSVLKNCIIGPNYVVEEGTHSQAVHLSNADQFMEIDIQ
Protein: Organic cation/carnitine transporter 7 (AtOCT7) (Q940M4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High affinity carnitine transporter involved in the active cellular uptake of carnitine. Also transports organic cations (By similarity).
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Nicotinate N-methyltransferase 1
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- UDP-glycosyltransferase 76C3
- UDP-glycosyltransferase 76C4
Sequence:
MADGNTRFTVDEALVAMGFGKFQIYVLAYAGMGWVAEAMEMMLLSFVGPAVQSLWNLSARQESLITSVVFAGMLIGAYSWGIVSDKHGRRKGFIITAVVTFVAGFLSAFSPNYMWLIILRCLVGLGLGGGPVLASWYLEFIPAPSRGTWMVVFSAFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLLFYRWTSESPRYLILQGRKAEALAILEKIARMNKTQLPPGVLSSELETELEENKNIPTENTHLLKAGESGEAVAVSKIVLKADKEPGFSLLALLSPTLMKRTLLLWVVFFGNAFAYYGVVLLTTELNNSHNRCYPTEKQLRNSNDVNYRDVFIASFAEFPGLLISAAMVDRLGRKASMASMLFTCCIFLLPLLSHQSPFITTVLLFGGRICISAAFTVVYIYAPEIYPTAVRTTGVGVGSSVGRIGGILCPLVAVGLVHGCHQTIAVLLFEVVILVSGICVCLFPFETSGRDLTDSISASKEPPSASV
Protein: Collagen alpha-1(XIX) chain (Collagen alpha-1(Y) chain) (Q0VF58)
Organism: Mus musculus (Mouse)
Function: May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
Sequence:
MRHTGSWKLWTWVTTFLLPACTCLTVRDKPETTCPTLRTERYQDDRNKSELSGFDLGESFALRHAFCEGDKTCFKLGSVLLIRDTVKIFPKGLPEEYAIAVMFRVRRSTKKERWFLWKILNQQNMAQISVVIDGTKKVVEFMFRGAEGDLLNYVFKNRELRPLFDRQWHKLGIGVQSRVLSLYMDCNLIASRHTEEKNSVDFQGRTIIAARASDGKPVDIELHQLRIYCNANFLAEESCCNLSPTKCPEQDDFGSTTSSWGTSNTGKMSSYLPGKQELKDTCQCIPNKEEAGLPGTLRSIGHKGDKGEPGEHGLDGTPGLPGQKGEQGLEGIKGEIGEKGEPGAKGDSGLDGLNGQDGLKGDSGPQGPPGPKGDKGDMGPPGPPALTGSIGIQGPQGPPGKEGQRGRRGKTGPPGNPGPPGPPGPPGLQGLQQPFGGYFNKGTGEHGASGPKGEKGDTGLPGFPGSVGPKGHKGEPGEPLTKGEKGDRGEPGLLGPQGIKGEPGDPGPPGLLGSPGLKGQQGPAGSMGPRGPPGDVGLPGEHGIPGKQGVKGEKGDPGGRLGPPGLPGLKGDAGPPGISLPGKPGLDGNPGSPGPRGPKGERGLPGLHGSPGDTGPPGVGIPGRTGSQGPAGEPGIQGPRGLPGLPGTPGMPGNDGAPGKDGKPGLPGPPGDPIALPLLGDIGALLKNFCGNCQANVPGLKSIKGDDGSTGEPGKYDPAARKGDVGPRGPPGFPGREGPKGSKGERGYPGIHGEKGDEGLQGIPGLSGAPGPTGPPGLTGRTGHPGPTGAKGDKGSEGPPGKPGPPGPPGVPLNEGNGMSSLYKIQGGVNVPGYPGPPGPPGPKGDPGPVGEPGAMGLPGLEGFPGVKGDRGPAGPPGIAGISGKPGAPGPPGVPGEQGERGPIGDTGFPGPEGPSGKPGINGKDGLPGAQGIMGKPGDRGPKGERGDQGIPGDRGPQGERGKPGLTGMKGAIGPVGPAGSKGSTGPPGHQGPPGNPGIPGTPADAVSFEEIKHYINQEVLRIFEERMAVFLSQLKLPAAMLSAQAHGRPGPPGKDGLPGPPGDPGPQGYRGQKGERGEPGIGLPGSPGLPGSSAVGLPGSPGAPGPQGPPGPSGRCNPEDCLYPAPPPHQQAGGK
Protein: Elongator complex protein 5 (Gamma-toxin target 5) (HAT-associated protein 2) (Protein IKI1) (P38874)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitivity to Pichia inositovora toxin.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15780940}. Nucleus {ECO:0000269|PubMed:10024884}.
Interaction partners:
- Elongator complex protein 1
- Elongator complex protein 3
- Elongator complex protein 6
- Elongator complex protein 4
- Elongator complex protein 2
- Protein KTI12
- Cytoplasmic tRNA 2-thiolation protein 1
- Histone H3
- Diphthamide biosynthesis protein 3
- Histone H4
Sequence:
MASSSHNPVILLKRILSLTESSPFILCLDSIAQTSYKLIQEFVHQSKSKGNEYPIVYISFETVNKPSYCTQFIDATQMDFVHLVKQIISYLPAATATQAKKHMVIIDSLNYISTEYITRFLSEIASPHCTMVATYHKDIKDENRTVIPDWNNNYPDKLTLLQFMATTIVDIDVVLTGTLDTEEVSELLNEFRIPRGLNNDIFQLRLVNKRKSGRSLEYDFIVNSNTHEYELLSTTKQEEESSSNGLETPEMLQGLTTFNLGTSNKQKLAKDQVALPFLEAQSFGQGGAIVYEYEKDDDYDEEDPYEDPF
Protein: Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase) (P52788)
Organism: Homo sapiens (Human)
Function: Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
Interaction partners:
- S-methyl-5'-thioadenosine phosphorylase
- Ornithine decarboxylase
- Spermidine synthase
- Guanidino acid hydrolase, mitochondrial
- Antizyme inhibitor 2
- Arginase-2, mitochondrial
- Peroxisomal N
- Arginase-1
- Methionine synthase reductase
- Phosphate-regulating neutral endopeptidase PHEX
Sequence:
MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFANLRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP
Protein: PRA1 family protein F2 (AtPRA1.F2) (Prenylated Rab acceptor 7) (Q9C889)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18583532}; Multi-pass membrane protein {ECO:0000269|PubMed:18583532}. Vacuole membrane {ECO:0000269|PubMed:17151019}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- PRA1 family protein H
- PRA1 family protein A3
- PRA1 family protein A2
- PRA1 family protein A1
- Binding partner of ACD11 1
- Sulfite exporter TauE/SafE family protein 4
- Aspartic proteinase A1
- Ras-related protein RABG3a
- Equilibrative nucleotide transporter 1
Sequence:
MTNYGAIPTSSHPSPAIDLEYISRAKHRIKSGLATRRPWKSMFDFESMTLPHGFFDAISRIKTNLGYFRANYAIGVLFILFLSLLYHPTSLIVLSILVVFWIFLYFLRDEPLVVFGYQIDDRTVLIGLSVLTVVMLLLTHATSNILGSLLTAAVLVLIHAAVRRSDNLFLDEEAAAVTEASGLMSYPSS
Protein: Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I) (P50096)
Organism: Mus musculus (Mouse)
Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03156}.
Interaction partners:
- GMP synthase
- Adenylosuccinate synthetase isozyme 2
- Adenylosuccinate synthetase isozyme 1
- Inosine-5'-monophosphate dehydrogenase 2
- Bifunctional purine biosynthesis protein ATIC
- AMP deaminase 2
- AMP deaminase 3
- AMP deaminase 1
- Hypoxanthine-guanine phosphoribosyltransferase
- Inosine triphosphate pyrophosphatase
Sequence:
MADYLISGGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKIQHGFSGIPITATGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRVELVVAPAGVTLKEANEILQRSKKGKLPIVNDQDELVAIIARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGAQSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
Protein: Cytochrome c oxidase subunit 5b-1, mitochondrial (AtCOX5b-1) (Q9LW15)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|PROSITE-ProRule:PRU00692, ECO:0000305|PubMed:25732537}.
Interaction partners:
- Cytochrome c oxidase subunit 6a, mitochondrial
- Cytochrome c oxidase subunit 6b-3
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 6b-1
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 6b-2
- Putative cytochrome c oxidase subunit 6b-like
- Cytochrome c1 2, heme protein, mitochondrial
Sequence:
MWRRIVSSQLKTLAADVVAASPRRSIAATTRPVGFYLAANRSAISASSFVIPRRFSSDSVETPATKKVEDVMPIATGHEKEELEAELEGRRLDDIDFPEGPFGTKEAPAIVKSYYDKRIVGCPGGEGEDEHDVVWFWLEKGKSFECPVCTQYFELEVVGPGGPPDGHGDEDDEHHH
Protein: GH12583p (Q7JWR6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLDKKIDEGPDYDSASETEIALEEARLNALRQHWESASITASICSSASRSLQTTPIRQVQVPLKQPPRGAGLLIQPSSASAVTASTSSSSSSTIVALPTTEYLPQHVLTGRQVVQQQQQQQQQQAAVLYQQQQQQLILLPQLDPNVVNTSTAAAAAQLVQLQQQHQQQQQQLQLQQQQQLQLNQQQQQQLYQQQQQQYLLTLPAGSKPQSVSPKRLIYGGPAATTLLCATGIKCNAPETYEPPTAPHSQIQQQQPPPPPPGAYYGEMMHGVQAAPAAEYKFPPAISVQRLAPQVQRQLRETQELIKDSCPQLYAAGYGSPGPPIRNPSRNPTRTRPTLETQFSQELS
Protein: Baseplate protein gp9 (Gene product 9) (gp9) (P10927)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Peripheral baseplate protein that is part of the tail fiber network. Connects the long tail fibers to the baseplate and, after virus attachment to a host cell, probably changes its conformation to trigger the signal for tail contraction. Involved in the tail assembly.
Subcellular location: Virion {ECO:0000269|PubMed:15315755, ECO:0000269|PubMed:2403438, ECO:0000269|PubMed:27193680}. Note=Present in 18 copies in the baseplate. {ECO:0000303|PubMed:21129200}.
Interaction partners:
Sequence:
MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVKVGTRHDIDTSTVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVWNYSIESMFGQKESPAEGTWNISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRVGNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ
Protein: Putative nucleotide-sugar transporter YMD8 (Q03697)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- UDP-N-acetylglucosamine transporter YEA4
- UDP-galactose transporter homolog 1
- Thiamine-repressible mitochondrial transport protein THI74
Sequence:
MNRTVFLAFVFGWYFCSIALSIYNRWMFDPKDGLGIGYPVLVTTFHQATLWLLSGIYIKLRHKPVKNVLRKNNGFNWSFFLKFLLPTAVASAGDIGLSNVSFQYVPLTIYTIIKSSSIAFVLLFGCIFKLEKFHWKLALSVIIMFVGVALMVFKPSDSTSTKNDQALVIFGSFLVLASSCLSGLRWVYTQLMLRNNPIQTNTAAAVEESDGALFTENEDNVDNEPVVNLANNKMLENFGESKPHPIHTIHQLAPIMGITLLLTSLLVEKPFPGIFSSSIFRLDTSNGGVGTETTVLSIVRGIVLLILPGFAVFLLTICEFSILEQTPVLTVSIVGIVKELLTVIFGIIILSERLSGFYNWLGMLIIMADVCYYNYFRYKQDLLQKYHSVSTQDNRNELKGFQDFEQLGSKKIAPYSISVDLTNQEYELDMIAQNVSRSSQQV