wanglab/gogpt-training-data huggingface dataset:
Protein: MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of sensor kinase 2) (P53599)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.
Interaction partners:
- Osmolarity two-component system protein SSK1
- MAP kinase kinase PBS2
- High osmolarity signaling protein SHO1
- Osmosensing histidine protein kinase SLN1
- Phosphorelay intermediate protein YPD1
- Serine/threonine-protein kinase SSK22
- Protein STE50
- Mitogen-activated protein kinase HOG1
- Protein OPY2
- Signaling mucin HKR1
Sequence:
MSHSDYFNYKPYGDSTEKPSSSKMRQSSSSSSSRLRSESLGRNSNTTQARVASSPISPGLHSTQYFRSPNAVYSPGESPLNTVQLFNRLPGIPQGQFFHQNAISGSSSSSARSSRRPSNIGLPLPKNPQQSLPKLSTQPVPVHKKVEASKTESEIIKKPAPVNSNQDPLLTTPTLVISPELASLNTTNTSIMSTPQNITNQTSNKHIPTRSQPNGSTSSSTLQDIVTTNSSQRSVGHHGGSTTSLRTYKKQYVLNEQLYLRKMRNRANDDYYTRGIVASSNFEDDEENFSNKGEDDLELEMDDLLKVEGEDKDNDFNFGYNFITSSTKNNENVVSMSLNYLKGKLDWLRDVNNDQPCEIEDEEWHSILGSEDLLSKLLQNPMVNNRFEWQTMLSKVLKGDIVRNEKTKIANQGKGPGFNTQFSDDIWIELKAWMNGRTVEDQNKSLRIFRDSTDSVFQEIMAFKLEDNMSADEAAETIKSLVDKYYRVLNLWPNIKRMHAEKPITKTEAFRNRIDTLNSWLNFKFNFDTNIAYLKKWIVGNKELESTTEVDNTTVNLDDPAVFATNCKRFAEQIMKEKDIELIFQKKIFFPLAPWILKAKFFFLKYQKTWNELNLSYLDQDLEFLLMFPMRLVKDIILIRLSYAKKIQNPTLMMIDQMMDDFSTYIKLAVQMKFTVASYCNDWFFKVKIDPEFDHTVVEGLEYFFSILELRILYSGKNSFKTSKEPDLLLKYWEMFRNVGYYIDDAGELIAAEFTKLTLRLVHRLHAYLLRQQNTPPKLENEAAAEKWLVQIFEILGSMKRKLNRFTNILTKAFQNFVRYKIEDHNYLLKQLKETGHFLIYTGGYLEQNGTYLIGSPELLGCKDDDILRIIKNSDIGCDLVPKLEINNSLTIYNALDDNWNSNSSLGSDISNDGTPFYYIKNDLTTQPRSYNGNRVNREPDFENSRSTEEEFYELETRLNSLGYVLVLTPQEPLLWEGEMYNLSDNKTIKPEGLNLKVIPNSIDLMCQGSSYALEYQCDRFQQISGSSVSFLEKKSSSETVKNNLQRINKAYFRCTYSVLKNYTKIVTTFKKVSPVNDLLNNIFLFGRDFGLNFLRINVANNEKRSIIILLMMRLSIGWLKFLAEDCDPTDQRVFRWCVTSMEFAMHMVSGWNILALDECQFSSLKQKISECMSLLISHFDIIGARSIEVEKINQQARSNLDLEDVFDDDMMLQVNSEFRVQSIMELEERIKRNPHQTGKVIDDSDKGNKYLVSLASSISNVSMRWQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEILNHPNIVSYYGVEVHRDKVNIFMEYCEGGSLAALLEHGRIEDEMVTQVYTLQLLEGLAYLHESGIVHRDVKPENILLDFNGVIKYVDFGAAKKIANNGTRLASMNKIENADGEHEDVTHVSDSKAVKNNENALLDMMGTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMITGRRPWANLDNEWAIMYHVAAGHTPQFPTKDEVSSAGMKFLERCLIQNPSKRASAVELLMDPWIVQIREIAFGDDSSSTDTEERE
Protein: Ribosomal RNA-processing protein 14-N (Ribosome biogenesis protein rrp14-N) (O14279)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in ribosome biogenesis and cell polarity. Required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable rRNA-processing protein ebp2
- Brix domain-containing protein C1B9.03c
- Ribosome biogenesis protein brx1
- Ribosomal RNA-processing protein 14-C
- ATP-dependent RNA helicase dbp9
- Protein mak16
- Brix domain-containing protein C4F8.04
- Uncharacterized RNA-binding protein C1827.05c
- Probable nucleolar GTP-binding protein 1
- Ribosome assembly protein rrb1
Sequence:
MTEVEERINAWNDGFEELLSYIPAKLYYREHTANQWKQKKSTLEEKKERRKMKFSLDGLVNDADDDSQKSSKWEQSSTMSDDTDVSDRHAESMSQIRGKLASKIQDLREKRKAGDLNQKRQNKRPVENEKDSQKGSGKSKVQKKKHKASPRAGF
Protein: SEC24 homolog C, COPII coat complex component (A0A286YDI8)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004397}.
Interaction partners:
Sequence:
MNVNQSAPPVPPYGQNQPIYPGYHQSSYGGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAPPSSGAPPASAAQVPCGQTTYGQFGQGDIQNGPSSTAQMQRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQGFGSLPVNQANHVSSPPAPALPPGTQMTGPPVPPPPPMHSPQQPGYQLQQNGSFGPARGPQPNYESPYPGAPTFGSQPGPPQPLPPKRLDPDAIPSPQLNELPPQQKTRHRIDPDAIPSPIQVIEDDRNNRGSEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPLMTFIEGGRRFQCSFCSCVNDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDYLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEENGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRAVLNSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVSSMDVAETNVFFYPRLLPLTKSPLDSTAEPPAVRASEERLSSGDIYLLENGLNLFVWVGASVQQGVVQSLFNVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRAQRMRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS
Protein: Uncharacterized protein (Q54Z78)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MFNSIKTLILLILCFSNYFIFCQESVHTVNIDNFPPLLTLFNGSTILFVVGLNTGDHIIFTKVTPKGVQPFTSPVLNLRRLQPSFSYTFSDAGKYVIMDMYTSEEMNLTIIDTLSPLSSSSSSSDSTNNQSKSSSSNSVNASSSSTKPPISSLETDSLNNSTSTTTTTSKSSHEKNESIQLLSSFSNLIFISIILLSL
Protein: RE14101p (Z band alternatively spliced PDZ-motif protein 66, isoform H) (Q86BH5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEYVQFKNGSPVYYKEQPDLNECIQYQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAHPGHDYHDSIMKQRVADTMLHKVVGSEADTGRVFHKQFNSPIGLYSNNNIEDTIRSTVPNQYQRQYPGRRTMW
Protein: Hepatocyte nuclear factor 1-beta (Transcription factor 2) (E0YMJ8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEITSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMDLSLRRRFAPSQHLDEYPQPLPP
Protein: Homeobox even-skipped homolog protein 1 (EVX-1) (P23683)
Organism: Mus musculus (Mouse)
Function: May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MESRKDMVMFLDGGQLGTLVGKRVSNLSEAVSSPLPEPPEKMVPHGCLSPRAGPPTSRERGGGGQEEEPVDGLAGSAAGLGAEPRSAGAAMLGPGPPVPSADSLSGQGQPSSSDTESDFYEEIEVSCTPDCATGNAEYQHSKAPGSDALGSSPTSGSEAPKSNGGSGGSGSQGTLACSASDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAAAGGLPYPFPSHLPLPYYSPVGLGAASAASAAASPFSGPLRPLDTFRVLSQPYPRPELLCAFRHPPLYPGPAHGLGASAAAAAAAGPCSCLACHSGPANGLAPRAAAAAAASDFTCASTSRSDSFLTFAPSVLSKASSVAALDQREEVPLTR
Protein: serralysin (EC 3.4.24.40) (E0SC35)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Alkaline protease secretion ATP-binding protein aprD
- Membrane fusion protein
- Alkaline proteinase inhibitor
- Outer membrane exporter of proteases
Sequence:
MALYGKKTDLSSASSGGYTGVADVYQLWNYHARGNGNIGDKPSYTLEQARDQITRGNITWNGEKVFGKSAALTYSFLQSVADSDMPDNFKGFVKFNAAQIQQTKLALQSWADVANVTFSEAKDGERATIQFGNYTLTPDGNTDNNSQAFGFYPGNWKWAGSAWFNYNQADNQRPDINEFGRNTLTHEIGHTLGLYHPGDYDASDGNPGYKDVTYAEDTRQFSIMSYWNEGYTGGDFHGYHAAAPLMDDIAAIQKLYGANMSTRTGDTVYGFHSNSGRDFYTATDSKTPLIFSVWDAGGNDTFDFSGYSANQRISLISGTFSDVGGLKGNVSIAAGAVMENAIGGSGHDVIVGNLSDNRIDGGAGNDVLYGDGGADILTGGAGKDIFVYAWEKDSLSSAPDTITDFQRGEDRIDLSAFNKNHDLRFVDNFSGKGNEVVLNWDSQSHQTNMWLHLSGHETADFLVNIVGAALQPSDVIV
Protein: Glutathione reductase (GR) (GRase) (EC 1.8.1.7) (P06715)
Organism: Escherichia coli (strain K12)
Function: Maintains high levels of reduced glutathione in the cytosol.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:6393625}.
Interaction partners:
- Thioredoxin/glutathione peroxidase BtuE
- Glutathione synthetase
- Glutathione S-transferase GstA
- Glutathione hydrolase proenzyme
- Glutathione S-transferase YfcF
- Glutathione S-transferase GstB
- Glutaredoxin 1
- Thiol:disulfide interchange protein DsbC
- Bifunctional glutathionylspermidine synthetase/amidase
- Glutathione-specific gamma-glutamylcyclotransferase
Sequence:
MTKHYDYIAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIREAIHMYGPDYGFDTTINKFNWETLIASRTAYIDRIHTSYENVLGKNNVDVIKGFARFVDAKTLEVNGETITADHILIATGGRPSHPDIPGVEYGIDSDGFFALPALPERVAVVGAGYIAVELAGVINGLGAKTHLFVRKHAPLRSFDPMISETLVEVMNAEGPQLHTNAIPKAVVKNTDGSLTLELEDGRSETVDCLIWAIGREPANDNINLEAAGVKTNEKGYIVVDKYQNTNIEGIYAVGDNTGAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTVGLTEPQAREQYGDDQVKVYKSSFTAMYTAVTTHRQPCRMKLVCVGSEEKIVGIHGIGFGMDEMLQGFAVALKMGATKKDFDNTVAIHPTAAEEFVTMR
Protein: Transcription factor Sp1 (Specificity protein 1) (O89090)
Organism: Mus musculus (Mouse)
Function: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component BMAL1. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112.
Subcellular location: Nucleus {ECO:0000269|PubMed:27918959}. Cytoplasm {ECO:0000250}. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location (By similarity). {ECO:0000250}.
Interaction partners:
- Estrogen receptor
- Histone acetyltransferase p300
- Transcription factor Jun
- Estrogen receptor beta
- TATA-box-binding protein
- Histone lysine acetyltransferase CREBBP
- Cellular tumor antigen p53
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 3
- Protein c-Fos
Sequence:
MSDQDHSMDEVTAVVKIEKDVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIIPNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESSSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTPQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHQLPGLPLAIANTPGDHGTQLGLHGSGGDGIHDETAGGEGENSSDLQPQAGRRTRREACTCPYCKDSEGRASGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNGF
Protein: Copper transport protein (Q9W3X9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|RuleBase:RU367022}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU367022}.
Interaction partners:
Sequence:
MDHAHHSAPGVDHSMHHDHVGMHHDHSGIPAATASPMDAASMFDLIPDTSDLQASHAGHAAHGAHNHGGGSGTGMEHMMPMAFHFGYNETILFSWWHIETVAGLIGSMIAIFLLALMYEGLKYYREYLFWKTYNLLEYRPVTGPQRNPEAPRIPSPAAAAPSPVQPSMLSINHLLQTLLHVLQVTLSFLLMLIFMTYNVWLCLMVVLGAAVGYFLFCWKKSVIVDVTEHCH
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q8ILL9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- HSP90 co-chaperone p23
- Heat shock protein 90, putative
- Heat shock protein 90
- Heat shock protein 90, putative
Sequence:
MENYNIEDVVMIYGHKAIIESIQNVENVKSEIQPNKIYVGKYVNKKGYSDGTYRKKKIYTPQNDELVILCSYNSIKPYNEEESACTMIQKMFRGYQGRKSFHSFVCCTVWRKFDHIHEYITLNNHDEIYKPLIKTIKRDIKKGIIQFPSKCFSSNSNQFSRVSTTSYESSNYNENVPRLKDKIDRTFATEMFHFFLTSKEIILPYNLVHKVLIKTKKMLEENIKSSVINLDMSKKSKDTKLIILGDVHGQLHDVLWLFNRFGIPSSTNIYIFNGDIADRGENATEIFILLFIFKLSCNDSVIINRGNHECSYMNEVYGFYNEVLSKYDNTIFDLFQNIFELLGLAVNVQNQIFVVHGGLSRYQDITLKEIDELDRKKQEILHPEQYEDIVIFDLLWSDPQKKEGIGGNARGNNCITFGPDVTEMFLKNNNLDILIRSHQVPKTLKGIESHHEGKCITLFSASNYCNKIKNLGAAIIFNQDLTFEVQEYMSPSLEVIRETFEENQKLREKVLHCSKIVELEKNEQKNNNKLSTEGLMNDIINCLSTIICNEKNSLWNNLYKQDKDKKGVVHINIWKEELGKLSKAKKVPWIYLCRKLKMIEDYHVNYNNILSRFKINYAPNEKFLNTEWKNECFEHLYEALLKADLSLRETLMVFDKNLDGKVSFAEFEQVLRDLNIDLSNEQIRILVRLINSNSLCNNTNLQENDKIDVAEFIGKMRVCYRLSINKDYVNNEKIQKLIETIGKHILSDSADTANYHYKFYEENNERHNSERRKRSSVIKSVALFQKFKNYDNFGNGYLDYNDFVKAIKNFDMNKISKEVEFEVDDDILMELAKSIDITKSSKINFLEFLQAFYVVNKSKYSYVDEIWCHICTVIYENKVALKKCMKYLEDTMQGKITSIHFRYILLELNKILQEHNFEMNKPLTDEQIDLLAYTVETDDKVDYVEFFNSFKPTYIYSNN
Protein: Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) (P54278)
Organism: Homo sapiens (Human)
Function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair.
Subcellular location: Nucleus {ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781}.
Interaction partners:
- DNA mismatch repair protein Msh6
- DNA mismatch repair protein Msh2
- DNA mismatch repair protein Mlh1
- DNA mismatch repair protein Msh3
- Exonuclease 1
- Fanconi anemia group J protein
- Fanconi-associated nuclease 1
- DNA mismatch repair protein Mlh3
- PMS1 protein homolog 1
- DNA polymerase delta catalytic subunit
Sequence:
MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN
Protein: Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) (P13084)
Organism: Rattus norvegicus (Rat)
Function: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes (By similarity). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P06748}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P06748}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P06748}. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Co-localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis. Can shuttle between cytoplasm and nucleus. {ECO:0000250|UniProtKB:P06748}.
Interaction partners:
- Tumor suppressor ARF
- Nucleolin
- Protein argonaute-2
- Large ribosomal subunit protein uL18
- Cellular tumor antigen p53
- RB-binding protein 4, chromatin-remodeling factor.
- Histone-binding protein RBBP7
- RuvB-like 1
- Tyrosine-protein kinase receptor
- Holliday junction recognition protein
Sequence:
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLDEDDDEDDEDDEDDEDDDDDDFDEEETEEKVPVKKSVRDTPAKNAQKSNQNGKDLKPSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
Protein: DNA helicase (EC 3.6.4.12) (A0A2R8Y212)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLCRQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKGEEEVTAVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDGSQEDRDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPAEDGIKIEENSLKEEESIEGEKEVKSTAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEKAEVKERTEEPMETEPKGKGAADVEKVEEKSAIDLTPIVVEDKEEKKEEEEKKEVMLQNGETPKDLNDEKQKKNIKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANRAPEPTPQQVAQQQ
Protein: SD23787p (Q86P45)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
CVKEEDLDSQQGVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTIDQLEKKWSHDKSNLGEILKTTSQTLTTQVTASEERAARAEAESRIEREWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEELGIQLSVSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVGSPGIWAPDSIATHCTACEREFNLTRRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDNCYAAK
Protein: Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2) (P12336)
Organism: Rattus norvegicus (Rat)
Function: Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (By similarity). Also able to mediate the transport of dehydroascorbate (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:3048704}; Multi-pass membrane protein.
Interaction partners:
- Hexokinase-4
- Cellular tumor antigen p53
- Sodium/glucose cotransporter 1
- Solute carrier family 2, facilitated glucose transporter member 1
- Insulin-2
- Insulin-1
- Glucose-6-phosphatase catalytic subunit 1
- Pro-glucagon
- Homeobox protein Nkx-6.1
- Uncharacterized protein.
Sequence:
MSEDKITGTLAFTVFTAVLGSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRRATINYDINGTDTPLIVTPAHTTPDAWEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAANSLSLTGALLMGCSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGILISQIAGLSFILGNQDYWHILLGLSAVPALLQCLLLLFCPESPRYLYLNLEEEVRAKKSLKRLRGTEDITKDINEMRKEKEEASTEQKVSVIQLFTDPNYRQPIVVALMLHLAQQFSGINGIFYYSTSIFQTAGISQPVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLAGMIGMFFCAVFMSLGLVLLDKFTWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFIIALCFQYIADFLGPYVFFLFAGVVLVFTLFTFFKVPETKGKSFDEIAAEFRKKSGSAPPRKATVQMEFLGSSETV
Protein: Lysosomal enzyme receptor protein (Q8IMR0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
MRCSLQKDCAAPTQENFRQMRFPIVISLLLLLFCSGESVAADAANQLKFSTTECKLKEPIYGSTFDFSGLHSDLAHVVKSMNIGGDQFEFNICGNLSRTCNGESNVAACLKRQGKEYILGRQHELFYNNGNMFLKYKSGAKCDNGTADKPNYQLHVMFSCDYTLDAQPMHVTPYANEVCSFYISYRTPLACLSIPEGLQSNSCRVGDTKSNGTFDLMPLSDSNYHTSNRQGAFFVINVCKPVLYGENSMCPAGSSVCLFDSKATNPKERFINFGNVQTHPVVEKGQLLLRHESPTPCAKNSSANYTSVIYFSCDKFIRNAHPEFAGLGADSCTYQFNFATPLACNDLKPCTAFTSTNELLDLSSLSSKPARTLLKDGKNYTIAVCAHAGAPCQENGGACYEQNSTTISLGNSNSQLRFNQTGSLYLLYEDGAECSTATGMRRWSTKIEFVCANNATKDNGASTAGGSDSLKIIEDSNCQLLIQYQTPLACREPIRCKATTYVDHTNDGLGSSGDELIDLTPLISATDNYEARVELPASMEHLVPKTTKFFLNVCRPLVPKYQLGCAGGSAACMAKVTAAGAPEEERSMGFPLVSLTQRNRTFAELAYLKGDPCPTDNTSELSTHILFNCNMRAGRGQPVLRSVEDCAYRFEWETNVFCPPHECTFSADTCDLVHDELGRRFNFKSAPFTKDGKIEIDYNATKMSVNICGAHRKAMTDYSQALVNIFFTHESPNCGREGTMNVQIRLICSDQTESSSTISSDQQCNLLYVQRTPSICEFLSLGATQQNFESNGSTSSSTSSSSTSTTTSTTTQASPAAILGAILSVTFCVTCLGLLAFSPARRQRIRRLFRRSNSAVRYSRVQSNEEANLLLEPNGEFTESDDDMLL