wanglab/gogpt-training-data huggingface dataset:
Protein: Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) (B2ZGJ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Interaction partners:
- Probable vesicular acetylcholine transporter-A
- Glycerophosphocholine phosphodiesterase 1
- Probable phosphatase phospho1
- Probable vesicular acetylcholine transporter-B
- Ethanolamine kinase
- Ethanolamine kinase
- High affinity choline transporter 1
- Ribonuclease P 14 subunit
Sequence:
MPVSKREQSKDTGDPCALPKLPIPPLKQTLDMYLTCMGHLVPEDQFRKTKAVVEKFGAPGGVGETLQKKLLERSEQKANWVYDYWLEDMYLNNRLALPVNSSPVMVFHKQNFKGQSDVLRFAANLISGVLEYKALIDGRALPVEHARGQLAGTPLCMDQYNKVFTSYRLPGTKTDTLVAQKSTVMPEPEHIIVACKNQFFVLDVMVNFRRLNEKDLYTQLERIRKMADIEEERQPPIGLLTSDGRTQWAEARNILIKDSTNRDSLDMIERCLCLVCLDEETATELNDSNRALLMLHGGGTDKNGGNRWYDKPMQFVIGADGCCGVVCEHSPFEGIVLVQCSEYLLRYMRGSPSKLVRAASMSELPAPRRLRWKCSPDIQTFLSASADRLQKLVKNLDMNVHKFTGYGKEFIKRQKMSPDAYVQVALQFTFYRCHGRLVPTYESASIRRFQEGRVDNIRSSTPEALAFVKAMASGSKITDAEKMELLWTAIKAQTNYTILAITGMAIDNHLLGLREIAKELKLEKPELFSDTTYATSIHFTLSTSQVPTTEEMFCCYGPVVPNGYGACYNPQTDHILFCVSSFRECAETSSDLFVKTLEGCLKEMQDLCRKCNTEVKPADSTQRMEGNPKVMKNGSKS
Protein: Uncharacterized protein (Q38AA6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDRASELMDEFFKKDPDIRRMLSPCLDELHGLDDAIRRVGHKHSLDPNNQDVTFEYATVLISHTRNSYVESGVRLMESLAFALWQRRWGGPTHAQLQQACKIEEPLPADGSAAPASPNLQQLVSSEEGREGQQMNGDVVSRNGKYGQRGCENPTRCSKDTLESDLVIFHYYLAVGWIKLKKYDNALSSLNRMLELKPGHPQGIALKQYVEAVSRQTITVAGLAGIAAISVAATVLMAFRRS
Protein: Uncharacterized protein, isoform A (Q9VDI5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ergic53, isoform A
- Myosin-2 essential light chain
- FI03653p
- MD-2-related lipid-recognition domain-containing protein
- Uncharacterized protein, isoform E
- Mechanosensitive cation channel Tmem63
Sequence:
MQMRVTELPAVQLLLPLILIGLASGQRVAPGVNPQHYQQVPQQVPQHHPPPPPQHHQPQYQQQVHSAPGVPPQQYQYEQVQVPVQQQAPVQYQQVPVQQQQQQHQPIHQQPTMQQQQQPQQGHHQQAGGHHHGQPQQVLNTGNIQQERAHIQEHMQVPIDTSKMSEAELQFHYFKMHDSDNNNKLDGCELIKSLIHWHEQGSKEQPNGEKPHVEEKVFSDEELVALIDPILQMDDTSRDGYIDYPEFIKAQQKAAEKQQQQQQQQQQPHEQQQQQQQQPVH
Protein: Alanine racemase (EC 5.1.1.1) (P83944)
Organism: Penaeus monodon (Giant tiger prawn)
Function: Highly specific to D- and L-alanine and does not catalyze the racemization of other amino acids.
Interaction partners:
Sequence:
QPAFSVVTRPTFYKLLKAGRDIGYDGTYTTSEDEWIANFTTGWSDQLSRRLSTRLPRLYTRNGKIVRICPSLEYLFLEASEPFTSRGITRHVAATTGCVQDLGTDLDFIRPGGAITGLCS
Protein: Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2) (P52569)
Organism: Homo sapiens (Human)
Function: Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:9174363}; Multi-pass membrane protein {ECO:0000269|PubMed:9174363}.
Interaction partners:
- Arginase-1
- Arginase-2, mitochondrial
Sequence:
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
Protein: Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase) (F1N2K1)
Organism: Bos taurus (Bovine)
Function: Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides. Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded.
Subcellular location: Lysosome {ECO:0000250|UniProtKB:Q9UHG3}.
Interaction partners:
- PLAC8 like 1.
- Regulating synaptic membrane exocytosis 4
- NAD
Sequence:
MDPAAPGLACSILRLGLGLLLLCSWWYPGSAEPRAPPEKIAVIGAGIGGTSAAYYLRQKFGKDVKIDVFEKGKVGGRLATLNVQGQEFESGGSVIHPLNLHMKRFVKDLGLSAVQSPSGLVGVYNGETLVYEESSWFIINMIKLIWHYGFQSLRMHMWVEDILDKFMRIYRYQSHDYAFSSVEKLLHSLGGDDYLGLFNRSLLETLQKAGFSEKFLDEIITPVMRVNYGQTTNINGFVGAVSMAGTDPGLWAVKGGNKLVCSRLLQASRSNLVSGLVMSIEEKTRTKQTGNPSKVYEVVYQTGSETHSDFYDIVLVATPLNRKMSNINFLNFDPPIEEFHQHYEPLVTTLIKGELNSTVFSSRALNEFHLGTVLTTDNPDLFINSIGLVSPVEEDNNPQPKADTAHVWKIFSAAALTKEQILKLFVSYDYAVKQSWLAYPHYTPPEKCPSIILHDQLYYLNGIEFAASAMEMSAIAGYNAALLAYHRWNGNTHMIDQEDLYERLKTEL
Protein: Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1) (One cut homeobox 1) (Q9UBC0)
Organism: Homo sapiens (Human)
Function: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.
Subcellular location: Nucleus.
Interaction partners:
- Neurogenin-3
- Hepatocyte nuclear factor 3-beta
- Hepatocyte nuclear factor 1-beta
- Pancreas/duodenum homeobox protein 1
- Hepatocyte nuclear factor 1-alpha
- Hepatocyte nuclear factor 3-alpha
- Hepatocyte nuclear factor 4-alpha
- Homeobox protein Nkx-6.1
- Nuclear receptor subfamily 1 group D member 1
- One cut domain family member 3
Sequence:
MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVAHRGSHLPPAHPRSMGMASLLDGGSGGGDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTTYTTLTPLQPLPPISTVSDKFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLSPLSSSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSSNSGNSSSSSSTCTKA
Protein: At5g23850 (Glycosyltransferase) (O-glucosyltransferase rumi-like protein (DUF821)) (Similarity to unknown protein) (Q9FF95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytochrome b561 and DOMON domain-containing protein At5g35735
- PAR1 protein
- Polyadenylate-binding protein 8
- Myb domain protein 116
Sequence:
MRNSPSKNGSAGGHSRTYTDTIWSPFVKSGLGISPNRSYALVSLLILLIVGAFISTRLLLDTTVLLEKKAATTTTTKTQTQTITPKYPRPTTVITQSPKPEFTLHCSANETTASCPSNKYPTTTSFEDDDTNHPPTATCPDYFRWIHEDLRPWSRTGITREALERAKKTATFRLAIVGGKIYVEKFQDAFQTRDVFTIWGFLQLLRKYPGKIPDLELMFDCVDWPVVRATEFAGANAPSPPPLFRYCGNEETLDIVFPDWSFWGWAEVNIKPWESLLKELREGNERTKWINREPYAYWKGNPMVAETRQDLMKCNVSEEHEWNARLYAQDWIKESKEGYKQSDLASQCHHRYKIYIEGSAWSVSEKYILACDSVTLLVKPHYYDFFTRGLLPAHHYWPVREHDKCRSIKFAVDWGNSHIQKAQDIGKAASDFIQQDLKMDYVYDYMYHLLTEYSKLLQFKPEIPRNAVEICSETMACLRSGNERKFMTESLVKQPADSGPCAMPPPYDPATYYEVVKRKQSTNMRILQWEMKYWSKQNQTGS
Protein: Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) (F6SEU4)
Organism: Mus musculus (Mouse)
Function: Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Note=Mostly in excitatory glutamatergic synapses (By similarity). receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity). {ECO:0000250}.
Interaction partners:
- Disks large homolog 4
- Glutamate receptor ionotropic, NMDA 2B
- Disks large homolog 3
- Disks large homolog 2
- Disks large-associated protein 1
- SH3 and multiple ankyrin repeat domains protein 3
- SH3 and multiple ankyrin repeat domains protein 1
- Glutamate receptor 1
- Voltage-dependent calcium channel gamma-2 subunit
- Disks large-associated protein 2
Sequence:
MSRSRASIHRGSIPAMSYAPFRDVRGPPMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLDEDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEAAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLNDISTALRNPNIQRQPSRQSERTRSQPMVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPAGHGGSSGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDSLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQVEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPPPRLQITENGEFRNTADH
Protein: Pleckstrin homology domain-containing family A member 8 (Phosphatidylinositol-four-phosphate adapter protein 2) (A0A2P1JJM6)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004198}.
Interaction partners:
Sequence:
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV
Protein: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (EC 3.6.1.17) (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Ap4A hydrolase) (Ap4Aase) (Diadenosine tetraphosphatase) (Nucleoside diphosphate-linked moiety X motif 2) (Nudix motif 2) (Q6PEC0)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity). Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity).
Interaction partners:
- Inosine triphosphate pyrophosphatase
- CTP synthase 2
- CTP synthase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Nucleoside diphosphate kinase 6
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase A
- Adenylate kinase 9
- Nucleoside diphosphate kinase homolog 7
Sequence:
MALRACGLIIFRRHLIPKVDNTTIEFLLLQASDGIHHWTPPKGHVDPGENDLETALRETQEETGIEASQLIVLEGFRRELNYVARKKPKTVIYWLAEVKDYDVEIRLSQEHQAYRWLGLDEACQLAQFEEMKATLQEGHQFLCSTPA
Protein: 3',5'-cyclic-AMP phosphodiesterase 4 (EC 3.1.4.53) (Phosphodiesterase 4) (DdPDE4) (cAMP-specific phosphodiesterase 4) (Q86H13)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16644729}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase A
- Cytosolic purine 5'-nucleotidase
- Adenosine kinase
- 3',5'-cyclic-nucleotide phosphodiesterase regA
- AMP deaminase
- Probable adenylate kinase B
- Adenylate kinase
- Adenylosuccinate lyase
- Probable adenine phosphoribosyltransferase
- Adenylate kinase isoenzyme 6 homolog
Sequence:
MFNNNNNDKINNTMMSNNPSGQIINLESIDCNSNLSNTTSIKDSNNNNNNNNNNNNNINNNINKINPNIDRKVLDDFNSKSIKIIDNKLNKKNSKKNLYSKEVDDDINKINLNKKIIPNETNSNNSNNNNNNSNNNNNNNNNNNNFNYNNNINSNNNIINNNNNINNNSNNNNNNNNNNSISLYVDTQEKSKKKVNAESLRGPIIFQNFILYTFFLIVIGTAEGTSWAPEIRVANFVPYCVMCVVLLEFNRLHKKPLLRIIFPLYTSNIPFAYMCIFSREARKYVLISLLFFASCLCIFLQSGIPDLRKHIVIFCIIFMINYGCCILFMDWFYIDTTGTKPYRGRILATKIHWGEEATILVSMALLGCIFIVLEKFIKSYARCVAEQHYQIQCLQKEKEKLQTEINISLKKLDLDTPIEKIMDILRSMINTSESENDKKQLIKVIAVLGSNKLYDPDFKFETCTDDAEVYSWLQSMLNREVGYSNVNNNNNMMMIENNNNNTIINNNLIEPTSPNFSKKLTSSDLIPRIRSMPEITDQGIQELIINNFLEWDFPVFQLSEITDGNPLFYMSYFLFSRHKFFEKFKIGIDCFKNFMRKIESGYDSTNPYHNSIHATDVLHNLNYFIEKSFGKFLTDIELFSMILAAIIHDFKHPGVNNHFQINSKSRLALKYNDKSILENYHLHQAFIIMNEPESGILLKLSDSVRKEIRETIIALVLSTDMAKHFNLVGRFKSMANSFPTTTNTQQPSSSSSSSSSTTIPTSTITPTPNSTTSTTTTTTTTTTTTNNNNNNNSNNNSLNNIINNCSSSNGSMGASGADNSNSNNTNNSNSNNQNQCGSSIFLNSNKKDRLLLMKISIKCADISNPSKPWNLYTNWSNRVTSEFYKQGDKEKESNMDVSAFMDRNKPATTKCQINFINIFVAPIYEIWSHHFPQFKLCYQNILSNLSRLEIEQQQQLQLQQQQQQQLQQQQQQQQQIHQQQQQQLHHHQQQQQFQHQQHQQQLQHQHQQQLNNQNQNQNQSNSNNSNSFGLTQSNYLIVV
Protein: Pleckstrin homology-like domain family A member 1 (Apoptosis-associated nuclear protein) (Proline- and glutamine-rich protein) (PQ-rich protein) (PQR protein) (Proline- and histidine-rich protein) (T-cell death-associated gene 51 protein) (Q8WV24)
Organism: Homo sapiens (Human)
Function: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11369516}. Cytoplasmic vesicle {ECO:0000269|PubMed:12738777}. Nucleus, nucleolus {ECO:0000269|PubMed:11369516}. Note=Colocalizes with intracellular vesicles. {ECO:0000269|PubMed:12738777}.
Interaction partners:
- Aurora kinase A
- Uncharacterized protein SLC67A1-AS
Sequence:
MRRAPAAERLLELGFPPRCGRQEPPFPLGVTRGWGRWPIQKRREGARPVPFSERSQEDGRGPAARSSGTLWRIRTRLSLCRDPEPPPPLCLLRVSLLCALRAGGRGSRWGEDGARLLLLPPARAAGNGEAEPSGGPSYAGRMLESSGCKALKEGVLEKRSDGLLQLWKKKCCILTEEGLLLIPPKQLQHQQQQQQQQQQQQQQQPGQGPAEPSQPSGPAVASLEPPVKLKELHFSNMKTVDCVERKGKYMYFTVVMAEGKEIDFRCPQDQGWNAEITLQMVQYKNRQAILAVKSTRQKQQHLVQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPHPHPHPHSHPHSHPHPHPHPHPHQIPHPHPQPHSQPHGHRLLRSTSNSA
Protein: Elongation of very long chain fatty acids protein 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5) (Q5SE05)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|HAMAP-Rule:MF_03205}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03205}. Cell projection, dendrite {ECO:0000256|HAMAP-Rule:MF_03205}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. {ECO:0000256|HAMAP-Rule:MF_03205}.
Interaction partners:
Sequence:
METFNYKLNMYIDSWMGPRDERVQGWLLLDNYPPTFALTVMYLLIVWMGPKYMRHRQPVSCRGLLLVYNLGLTILSFYMFYEMVSAVWHGDYNFFCQDTHSAGETDTKIINVLWWYYFSKLIEFMDTFFFILRKNNHQITFLHIYHHASMLNIWWFVMNWVPCGHSYFGASLNSFIHVLMYSYYGLSAVPALRPYLWWKKYITQVQLIQFFLTMSQTICAVIWPCDFPRGWLYFQIFYVITLIALFSNFYIQTYKKHLVSQKKEYHQNGSVASLNGHVNGVTPTETITHRKVRGD
Protein: ABC transporter G family member 24 (ABC transporter ABCG.24) (Q54T02)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MIIFKNNEIRFNSILKSILLLLLLFINGNNCKTAQQFLDENFNHALFREHQLEKEYKTKQLVKDDPNMYSDWTEVPAATAEAVTIMRGDDYYYDYDKEQKIEMIVFGSENAISSGSAQNYWYGQTCEATNFNNTPTTTCPNDCHSYWGQGQCNETSSTCICNYFFIGDDCSENVDPQHNWDKMNCNGGRYCPPIYNYPTPRSCVCPPGQAGLECTVCLNNEGCQALTGNYSSSFECNSSPYTYFEKSYSCVVTSAEVNGDLNNSTASASIDCQFPGGNYNTQTGVCSMNLYYRIHGSPLYFNCSFTECDRTILPGQNQSIVCQNSVCNCTTYCGFILDGLISAVTGEATFECGAQTNPDGTSNCLFSQYTINQMLPAIPLQCMSGECIDVATGAPTPPPIYPVPVASMSFLYIYVGSGVGFIGLTLLIGAIFLIFSLQEDRKNFKEDTHLVCELSFHNISCYVNERSGFFGKDVKRKQILDNVNGVCPPGQLTALMGLSGSGKTSLLDILSGRKNVGNIDGKVLINGAPVGKNFKRISGYVTQDDIQIGTLTCREHLMFAALLKLPENMSLEIKQQRVASVLEELGLTRVADNPIGTSEKRGISGGERRRLSIATELIVDPSILFIDEPTSGLDSHSASELITKLKQLANNSTKGQRTIIFSIHQPSAELFEQFDNLILLHQGNPYFSGKREDSVNYFIKQKIAGMTEFEQQNYRMHLKNPADFIISMVTDKNCQRFNSTYVDSRVASPFYQSTSPALSSNSNNSDINLNHHRIINNPHNQNIHHQQHHHHHRHIYGINGPSIDNNDSDSDSDERDHLLASDNINNNNNNNKVKNNDNNNKNNDDDVEDIEEASPIIVVGNQGEPLASHIKIGKVEEYATSFWTQFFVVCRRSLLNYMRNPFLLRTTYFVHIFVGLTLGYLFWKLPANLEPGCQNRFGAMFFMTALLSFGSITSLDLFYNDRIIFIRERANGFYRTSAYFLAKVVTDIIPMRVIPPIILGSICYYMIGLRPGILHFIYFLISLVLTSTVASSMCMAISTISPTFGTANMVSILLLFVFLLFDGFLLARSSIPKYLIGLVWISFMSYGLEIPVVNEFNGLWIEYNPPNTRPTYADGLEFLSTIGANPNRLFTDMYVLLGMIVGYLLLAYVFLRFLVREYR
Protein: Methoxy mycolic acid synthase MmaA3 (EC 2.1.1.-) (Mycolic acid methyltransferase) (MA-MT) (S-adenosylmethionine-dependent methyltransferase) (AdoMet-MT) (SAM-MT) (Q7U1K0)
Organism: Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Function: Involved in the biosynthesis of methoxymycolic acid. It catalyzes the O-methylation of the hydroxy group of the hydroxymycolate to form a methyl ether.
Interaction partners:
Sequence:
MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFERDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGLTLSKNQHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQPHFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDCNQFTLAK
Protein: AIG2-like protein B (EC 2.3.2.-) (Avirulence-induced gene 2-like protein B) (Putative gamma-glutamylcyclotransferase) (Q9FIX1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative gamma-glutamylcyclotransferase.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15060130}.
Interaction partners:
- Proteasome subunit alpha type-2-B
- Proteasome subunit alpha type-2-A
Sequence:
MSSSDSPQLHNIFVYGSFQEPDIIHVMLNRIPEIVSATLPGFKRFRLKGRLYPCIIPSENGEVHGKVLMGLTNDELENVDWVEGNEYERVFVEVVRKDNSEKMRVETYPWINKNDPDIGGEWDFEEWKRLHMKTFIEAFTEIMERKRNPQGKGRDDFSNVLKEEDPANAPSS
Protein: Filament-like plant protein 3 (AtFPP3) (Protein VESICLE TETHERING 1) (Q9MA92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ensures, when in complex with COG2 and FPP2/VETH2, the correct secondary cell wall (SCW) deposition pattern by recruiting exocyst components to cortical microtubules in xylem cells during secondary cell wall deposition by recruiting EXO70A1.
Subcellular location: Vesicle {ECO:0000269|PubMed:25541219}. Note=Present in vesicle-like small compartments which exhibit microtubule plus-end-directed and end-tracking dynamics. {ECO:0000269|PubMed:25541219}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 2
- At5g19870)
- Transmembrane E3 ubiquitin-protein ligase FLY2
- Endo-1,4-beta-xylanase 3
- At1g58070
- 65-kDa microtubule-associated protein 8
- Interactor of constitutive active ROPs 1
- Protein TRACHEARY ELEMENT DIFFERENTIATION-RELATED 6
- Glucuronoxylan 4-O-methyltransferase 1
- Fasciclin-like arabinogalactan protein 7
Sequence:
MDRRSWLWRRKSSEKSPGETESTGSVSSHSERFSDDQRSQSPELNSKPVTREEEATADIKILTERLSAALLNVSLKEDLAKQHAKVAEEAVSGWEKAENEAAALKQQLDASTSKVSALEDRNSHLDSALKECVRQLWQGREEQNQKIEEAINNKCKEWETTKSQLEARIEELQARQDVTTSSVHEDLYPKLEALEKENSALKLQLLSKSEEVKIRTIERDLSTQAAESASKQQLEGIKKLTKLEAECRKLRVMVRRSDNSSDLKSSIDNQSDYSGRVSFSDNEMQSPSEKIIGKSSMATSVDIGLMDDFLEMEKLAALPHSEPGRKHSESNKELEKSNAHVNQLKHELKTSLRRISELEEKVEMVEVEKLQLEMALNGSKEQIEALQSRLKEIEGKLSEMKKLEAENQELELLLGESGKQMEDLQRQLNKAQVNLSELETRRAEKLELTMCLNGTKKQLETSQNRLKETERKLTELQTLLHLTKDAKEAAEDGLKAANGKTEAIESRLKDVEAEAESLILKIKSLEDVTEKERALSAKHNSKCNELQDEISKLKQELEHHQETEPAPNHIKGFELKQEKELAVAASKFAECQRTIASLGQRLQSLATFEDFLIES
Protein: Ubiquitin carboxyl-terminal hydrolase mug105 (EC 3.4.19.12) (Lys-48-selective deubiquitinase mug105) (DUB) (Meiotically up-regulated gene 105 protein) (O13979)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Deubiquitinase with endodeubiquitinase activity that preferentially cleaves 'Lys-48'-linked polyubiquitin chains. Shows only weak activity against 'Lys-63' and 'Lys-11'-linked chains. Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22146723}.
Interaction partners:
- Polyubiquitin
- 26S proteasome regulatory subunit rpn11
- Probable ubiquitin carboxyl-terminal hydrolase 8
- Ubiquitin carboxyl-terminal hydrolase 6
- Probable ubiquitin carboxyl-terminal hydrolase 9
- Ubiquitin-ribosomal protein eL40A fusion protein
- Ubiquitin-conjugating enzyme E2 13
- Ubiquitin carboxyl-terminal hydrolase 15
- Probable ubiquitin carboxyl-terminal hydrolase 12
- Ubiquitin carboxyl-terminal hydrolase 14
Sequence:
MSKCLQQLKRQLQHFGIDGCSLADGDIDYFFTVTGIDRGWGCGWRNIQMLISWLQYTNPNWFKRNFSSGNYEINSLQSLLLSAWMKGIDAEGYAQLGDNLHGKWIGATEVYSLFTGLFVNVALVDFDFRSEASASNALFLYVKKHFESSNDTSNVSPCYLQFQGHSIIIIGFCSSLETLVVLDPDRYQSVQKKFVNIADFNHCYMRKKRSLKFSQFQLVHFKQNIFLNDFSSKLEVRSTRISDF
Protein: Calcium-activated potassium channel subunit beta-4 (BK channel subunit beta-4) (BKbeta4) (Calcium-activated potassium channel, subfamily M subunit beta-4) (Charybdotoxin receptor subunit beta-4) (K(VCA)beta-4) (Maxi K channel subunit beta-4) (Slo-beta-4) (Q9JIN6)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity).
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Potassium channel subfamily U member 1 current)
- Calcium-activated potassium channel subunit beta-1
- Calcium-activated potassium channel subunit alpha-1
- Small conductance calcium-activated potassium channel protein 3
- Intermediate conductance calcium-activated potassium channel protein 4
- Small conductance calcium-activated potassium channel protein 1
- Calcium-activated potassium channel subunit beta-2
- Small conductance calcium-activated potassium channel protein 2
- cGMP-dependent protein kinase 1
- cAMP-dependent protein kinase catalytic subunit beta
Sequence:
MAKLRVSYEYTEAEDKSIRLGLFLIVSGILSLFIFGFCWLSPALQDLQATAANCTVLSVQQIGEVFECTFTCGTDCRGTSQYPCVQVYVNNSESNSRALLHSDQHQLLTNPKCSYIPPCKRENQKNSESVMNWQQYWKDEIGSQPFTCYFNQHQRPEDVLLQRTHDEIALLHCFLWPVVAFVVGVLIVVLTICAKSLAVKAEAMKKRKFS