wanglab/gogpt-training-data huggingface dataset:
Protein: Tumor protein p63-regulated gene 1 protein (Protein FAM79B) (Q8CB49)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18256694}.
Interaction partners:
- Serine/arginine-rich splicing factor 2
Sequence:
MSTIGSFDGFQPVSLKQEEEDQPSENDHLSTKEGNSGKDPGSRRISRQQSITKATLYPNPYRQPYVSRKYFVTRPGAIETAVEDLKGHIAQTSGETVQGFWLLTEIDHWNNEKEKILLLTDKTLLICKYDFIMLSCVQVQQVPLNAICCICLGKFVFPGMSLDKRPGDGLRIFWGSTEGWSLLSRWNPWSTEVPYATFTEHPMKQTSEKFLEICKLSEFTSKLVPAIENAHKNSAGSGSGKELVVLTQPILIETYTGLMSFIGNRNKLGYSLARGSIGF
Protein: SH3 domain protein, conserved (Q585Z5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSLFTVHCNFTAQEDVELSVRKGEIVTAIDEDTHDGWVQVEVVGDKERVGFVPLSHLTPSVAQVGGDSRLQSSAVGATSLGNCSFLVDESPKVCNSAKQSKLDCSYMLNKHNSHSMIGNNYDSVGTVGGSSYVNAMELDVVANTHVRSLSDTDQATRRAQISGKTLGTNLQSATDPSTNSLLYDTGAVVESFMKNELHLKQLARRRQDELAKMRSALEEAKNDVGVCREKKEKLAVKLRDLDLSMDRMRKRWKNMLEQEKDHILRSMTSSGIDH
Protein: Chordin (Protein chordino) (O57472)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Bone morphogenetic protein 4.
- Bone morphogenetic protein 2
- Bone morphogenetic protein 7
- Bone morphogenetic protein 2a.
- Growth differentiation factor 7.
- Dorsal-ventral patterning tolloid-like protein 1
- Follistatin 2
- Bone morphogenetic protein 5.
- Bone morphogenetic protein 6.
- Bone morphogenetic protein 16.
Sequence:
MMEGLLWILLSVIIASVHGSRLKTPALPIQPEREPMISKGLSGCSFGGRFYSLEDTWHPDLGEPFGVMHCVMCHCEPQRSRRGKVFGKVSCRNMKQDCPDPTCDDPVLLPGHCCKTCPKGDSGRKEVESLFDFFQEKDDDLHKSYNDRSYISSEDTSTRDSTTTDFVALLTGVTDSWLPSSSGVARARFTLSRTSLTFSITFQRINRPSLIAFLDTDGNTAFEFRVPQADNDMICGIWKNVPKPHMRQLEAEQLHVSMTTADNRKEELQGRIIKHRALFAETFSAILTSDEVHSGMGGIAMLTLSDTENNLHFILIMQGLVPPGSSKVPVRVKLQYRQHLLREIRANITADDSDFAEVLADLNSRELFWLSRGQLQISVQTEGQTLRHISGFISGRRSCDTLQSVLSSGAALTAGQTGGVGSAVFTLHPNGSLDYQLLVAGLSSAVLSVSIEMKPRRRNKRSVLYELSAVFTDQRAAGSCGRVEARHTHMLLQNELFINIATALQPDGELRGQIRLLPYNGLDARRNELPVPLAGVLVSPPVRTGAAGHAWVSVDPQCHLHYEIIVNGLSKSEDASISAHLHGLAEIGEMDDSSTNHKRLLTGFYGQQAQGVLKDISVELLRHLNEGTAYLQVSTKMNPRGEIRGRIHVPNHCESPAPRAEFLEEPEFEDLLFTREPTELRKDTHTHVHSCFFEGEQHTHGSQWTPQYNTCFTCTCQKKTVICDPVMCPTLSCTHTVQPEDQCCPICEEKKESKETAAVEKVEENPEGCYFEGDQKMHAPGTTWHPFVPPFGYIKCAVCTCKGSTGEVHCEKVTCPPLTCSRPIRRNPSDCCKECPPEETPPLEDEEMMQADGTRLCKFGKNYYQNSEHWHPSVPLVGEMKCITCWCDHGVTKCQRKQCPLLSCRNPIRTEGKCCPECIEDFMEKEEMAKMAEKKKSWRH
Protein: Deoxyribonuclease II (EC 3.1.22.1) (Q9VED8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRSLCFVLLFVWFFYQNEAKSKVSCKDEAGNDVDWWHLYKLPKHYQHNDLGKDTSGLKYLYVTSQNYDTWQMSGKFISDPLSLPAQTLNPLNDDPSHTLLAAYNDQQPNGTVFSSGGHAKGVVASDGETAIWIVHSVPKFPTIPDYSYPTSGEQYAQSMLCVTLKGEDLEKVGQILVYNEPHFYYQRNPLATRSDELFPSLERALHGQWRTESPFQKDLEVRSLDGKKFRLFGKSGRANVELYADVVAPTLDVSLFVEAWRDGAGNLPNSCDKSDKVLNVESISNPELSVDFKTTQDHSKWAVSRPTGILIYHWRVGGGDWICVGDINRQEGQLHRGGGTVCHKSARVSNLYRQLVTNYDKCAQQE
Protein: Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8) (Q9D7W5)
Organism: Mus musculus (Mouse)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 28
Sequence:
MQREEKQLEASLDALLNQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPGDTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTILAGASGLPQVQMPGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR
Protein: Deoxyuridine triphosphatase, putative (EC 3.6.1.23) (Q57ZH3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Bifunctional dihydrofolate reductase-thymidylate synthase
- thymidine kinase
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase, putative
- Nucleoside diphosphate kinase, putative
- dTMP kinase
- dTMP kinase
Sequence:
MKNARRVSLSPLILRSLAELQDGLNTVVDKNWRQLRRPGDWSLAITMEAAELLDSYPWKWWKNVKAQPDLQNVKIELTDILHFSLSGAMQVSDENSGAVHKAEAGSNGESGKHWCYFDQPRALPAAGGAEYVACVETPGSSLSAPVSADECDLADFMFFPLSDTNNALASFQNIIRLASLQRFQLVTSAVIAAADDIGFNLVAYYVAKHTLNGIRQMKGYKDGTYVKVQKGVEDNELLHGCISPFSLDDVTNEGNYKTKWDDIMHRVYDAFGTPKEERLNIGHWLKS
Protein: Casein kinase II subunit beta' (CK II beta') (P38930)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity).
Interaction partners:
- Casein kinase II subunit beta
- Casein kinase II subunit alpha'
- Casein kinase II subunit alpha
- U3 small nucleolar RNA-associated protein 22
- Ribosomal RNA-processing protein 7
- Protein IFH1
- U3 small nucleolar RNA-associated protein 10
- FACT complex subunit SPT16
- U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 21
Sequence:
MGSRSENVGTVTREGSRVEQDDVLMDDDSDSSEYVDMWIDLFLGRKGHEYFCDVDPEYITDRFNLMNLQKTVSKFSYVVQYIVDDLDDSILENMTHARLEQLESDSRKLYGLIHARYIITIKGLQKMYAKYKEADFGRCPRVYCNLQQLLPVGLHDIPGIDCVKLYCPSCEDLYIPKSSRHSSIDGAYFGTSFPGMFLQAFPDMVPKHPTKRYVPKIFGFELHKQAQLTRWQELQRLKLVEKLESKDVDLTKSGGFKT
Protein: CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (CD antigen CD81) (Q62745)
Organism: Rattus norvegicus (Rat)
Function: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype. Present in MHC class II compartments, may also play a role in antigen presentation (By similarity). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction. In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (By similarity). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P35762}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P60033}; Multi-pass membrane protein {ECO:0000255}. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000250|UniProtKB:P60033}.
Interaction partners:
- CD19 molecule
- Complement C3d receptor 2.
- Prostaglandin F2 receptor negative regulator
- CD63 antigen
- CD9 antigen
- Integrin beta-1
- Tumor susceptibility gene 101 protein
- CD82 antigen
- Claudin-1
- Immunoglobulin superfamily member 8
Sequence:
MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTTLLYLELGDKPAPSTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVMDDDANNAKAVVKTFHETLNCCGSNTLTTLTTAVLRNSLCPSSSNSFTQLLKEDCHQKIDELFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY
Protein: RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1) (P03430)
Organism: Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
Function: RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
Subcellular location: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04065}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04065}.
Interaction partners:
Sequence:
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFETSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMNKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKRKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKIRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRHTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVNRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTHSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVNHKDIESVNNAVIMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK
Protein: Protein CYCLOPS (PsCYCLOPS) (Protein IPD3 homolog) (PsIPD3) (PsSYM33) (A9XMT4)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Involved symbiotic signaling. Required for root infection by symbiotic rhizobia, infection thread (IT) formation, and nodule development. Required for symbiosome formation (i.e. the release of the bacteria from the ITs) and subsequent symbiosome development. Involved in arbuscular mycorrhizal (AM) symbiosis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:A7TUE1}.
Interaction partners:
Sequence:
MEGRGFSGLYKNSSEELFLKTVMESPIGMPVPTMEMLGFKTVSQSFRADSEELFKRWLTNEEGYNSTSMGLNSRLSKRISTELVNVSNQQHVGVASEGRNNDKSCLQNSFLTNDVSGDFNFPIREPVDRELQSGNLFLAKAWFLTDQRMTRSRSSELRRRYTEMQNTQAPQGLDSMFMAPKHDANIIKEELAHFNGFDYLSMCEIPSQKGSFMSPSNSSSSTFNTQQLVDVDKVSSCVSMLKGTLQRKRLECQVEKDAAEDGLNEIFGIREPLFQSGFNEGQENWNHQKLVNVQGDFTDQVKDTGVIETLEGAANFVLEGFANQTSQIHGGTASGEPSQSESSAAAPVISSGLDACEGPSNSSQTLCDSSWKQVGESTQNRAKGVREQIMDNLKDDRKRKRLERYGSVTSAVSDDKVDTTKKRRVERSRKMAEAKERNLTPTIPSDMQAVMKRCENLEKEVRSLKLNLSFMNRKDSEQTKQIEDLQKQNEELADEKERLLEEIERLLSETGKI
Protein: Peptidoglycan-binding protein ArfA (Outer membrane porin A) (Outer membrane protein A) (OmpATb) (Outer membrane protein ArfA) (P9WIU5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Probably plays a role in ammonia secretion that neutralizes the medium at pH 5.5, although it does not play a direct role in ammonia transport. The OmpA-like domain (196-326) binds M.tuberculosis peptidoglycan. Overexpression in M.bovis or M.smegmatis gives channels with average conductance value of 1,600 +/- 100 pS, but this may not be physiologically relevant.
Subcellular location: Secreted, cell wall. Cell outer membrane. Note=Does not have a cleavable signal sequence.
Interaction partners:
- Uncharacterized membrane protein ArfC
- Uncharacterized membrane protein ArfB
- Uncharacterized protein Rv0898c
- Uncharacterized protein Rv0897c
- Copper transporter MctB
Sequence:
MASKAGLGQTPATTDARRTQKFYRGSPGRPWLIGAVVIPLLIAAIGYGAFERPQSVTGPTGVLPTLTPTSTRGASALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN
Protein: Time for coffee (B3H7F6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDRNREARRVPMAAAGNGLSRRRHRAGSFRDSPEEEGPVELPEAARLRDRGGSNKKDRDRERDRDRERERERDRERDRLNSRSKRRRGERLMMVHGNLDDGGDDSSEESVNDDEEYDDGGVGPPSSLKMLPPTSNNISAASFSSSLSNHHNGGSGNLHHHHHSHNNNHQRKNNFPPTKVFRSSPSPAPVSPLVSTWKAADEMIGVSVPRKARSACTKRPHESWASSTTGGGVFASGEQIHRQISSTSPANRVSPASILASPSPPAPTSPSSSSISVRKKLPSGTKQKPLPPKSSSSKLSSPVAVQDEIEIEIAEVLYGMMRMPSTSKQEAAGNDLTEAAKSTVEVKSRVSSPISNPQTLPQSSITLAANSSSSNVSAIAPKRKKPRHVKYEDDNSSRVTTIKSEAEAPSKSQVPFSNQLKSSGSGEGNSSVLDSIIPLTRESNASLDSEKKENNLSKDETILPKVESSSGFRSDGEGAKSSSPEKEKFEIDLMAPPPVRSSSERGGEMMECVAAEAKPKVTEVETEAKPLLKEDRSDPAIHDSQEKKRPRMVAEAEHHKFERNCELKLDLDKSDHVGLVNKHHVQKPPPQQQLSVPDKTAQASHLPLHMSMPGWPGGLPTMGYMAPTQGVVPTDTSSLSAAAMQPPPHLLFNQPRPKRCATHCYIARNIQSHQQFTKMNPFWPAAAGSAPMYGTKACNLSLMPPTELQGSVLGRSSNPVQDKNSQSTSKSSETAQRNQLMLQQALPPGAANSILHGPTFIFPLGQQPHAAATIAAASVRPPNSGITSSGPTATSTSMNGSASATPAGAPTMSFSYPAMPGNETQYLAILQNNGYPFPVPAHVGAQPAYRGAPGQPMPFFNGSFYSSQMIQPPHHQPQKQHQQQLTGQMLQSHAPNNQNGSASTGSSAAQKHLQNQQLRPPINHGNSQGFPTHKVQSQPLNFQQRQQPRENATQHSETVGEDSPSTADSRGSRSNVAYGQNYGMQMQPTNLGLMSSPAPGGGVVGSSSSHGEKKSQQQVSKAGVESFQSPGYAMTFATFNGANTAPTLNMSSIAQNHAMFHSMPEAARQGYQMMAAQAAQQKMNYGASLEDGKSGSIGGAATANNTPEEQRKSGGGAIGKTSGGNGGQSIAFSNKQDLADASVSAVTSGSIVDSSSRLLNLGSALPQSSGSLPTSHHQQLLQQQQQQHMQRSQSQQPYTTMYLQKQQRYATSVAASAARTKGPVVSNGSGFPDHNMTTSPAGTTKFANANSGFPQNLVQSSSNQVQSQQWKNNSPRTTNTTQAQSPSMLSPSTSVAAASSLRNIPHKQQSRPQQSQISFAANSKPMTSGSPMQQVQGGTNHQAPSPPMLVGSPSTSSVSKNASGSPRTTASASSAANKGGQASTTTHSASQPSKNLQPASAASSAGGRNNGPSVLGNPTTSSGSKSQQQQQLPKHGLQPQAQLFFSNPYMQAQHQHQQQQITISPSGGYYIQRHQQQSGSAPAVPVTGAVTATSDPAKAIAAASAANNMKGGGGMGKTQQHQLGPPGFTNVHAVSSAVQVKPVDQKQQAACAGETK
Protein: AB hydrolase-1 domain-containing protein (P71702)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MLSDDELTGLDEFALLAENAEQAGVNGPLPEVERVQAGAISALRWGGSAPRVIFLHGGGQNAHTWDTVIVGLGEPALAVDLPGHGHSAWREDGNYSPQLNSETLAPVLRELAPGAEFVVGMSLGGLTAIRLAAMAPDLVGELVLVDVTPSALQRHAELTAEQRGTVALMHGEREFPSFQAMLDLTIAAAPHRDVKSLRRGVFHNSRRLDNGNWVWRYDAIRTFGDFAGLWDDVDALSAPITLVRGGSSGFVTDQDTAELHRRATHFRGVHIVEKSGHSVQSDQPRALIEIVRGVLDTR
Protein: Intracellular subtilisin protease (D0AB41)
Organism: Shouchella clausii (Alkalihalobacillus clausii)
Interaction partners:
Sequence:
MRKFRLIPYKQVDKVSALSEVPMGVEIVEAPAVWRASAKGAGQIIGVIDTGCQVDHPDLAERIIGGVNLTTDYGGDETNFSDNNGHGTHVAGTVAAAETGSGVVGVAPKADLFIIKALSGDGSGEMGWIAKAIRYAVDWRGPKGEQMRIITMSLGGPTDSEELHDAVKYAVSNNVSVVCAAGNEGDGREDTNEFAYPAAYNEVIAVGAVDFDLRLSDFTNTNEEIDIVAPGVGIKSTYLDSGYAELSGTSMAAPHVAGALALIINLAEDAFKRSLSETEIYAQLVRRATPIGFTAQAEGNGFLTLDLVERITGQFTEKGKK
Protein: Eukaryotic translation initiation factor 2 subunit gamma (eIF2-gamma) (EC 3.6.5.3) (P32481)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09130}.
Interaction partners:
- Eukaryotic translation initiation factor 2 subunit beta
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit epsilon
- Eukaryotic translation initiation factor 2 subunit alpha
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 1A
- Translation initiation factor eIF2B subunit alpha
- Eukaryotic translation initiation factor 5
- Translation initiation factor eIF2B subunit gamma
Sequence:
MSDLQDQEPSIIINGNLEPVGEPDIVEETEVVAQETQETQDADKPKKKVAFTGLEEDGETEEEKRKREFEEGGGLPEQPLNPDFSKLNPLSAEIINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCQEPTCPEPDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRPGIVTKDDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLGVKTDGQKQAKVRKLEPNEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRIEKHWRLIGWATIKKGTTLEPIA
Protein: Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) (Q969H4)
Organism: Homo sapiens (Human)
Function: May function as an adapter protein or regulator of Ras signaling pathways.
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Kinase suppressor of Ras 1
- Ras association domain-containing protein 1
- Rhophilin-1
- Ral guanine nucleotide dissociation stimulator
- Cytohesin-3
- Transforming protein RhoA
- RAF proto-oncogene serine/threonine-protein kinase
Sequence:
MEPVETWTPGKVATWLRGLDDSLQDYPFEDWQLPGKNLLQLCPQSLEALAVRSLGHQELILGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGDCAKTPIDVLCAAVELLHEADALLFWLSRYLFSHLNDFSACQEIRDLLEELSQVLHEDGPAAEKEGTVLRICSHVAGICHNILVCCPKELLEQKAVLEQVQLDSPLGLEIHTTSNCQHFVSQVDTQVPTDSRLQIQPGDEVVQINEQVVVREERDMVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGTPGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLKAKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSEGLGAWGVAQAEGSSHILTSDSTEQSPHSLPSDPEEHSHLCPLTSESSLRPPDL
Protein: Nucleolar GTP-binding protein 1 (O44411)
Organism: Caenorhabditis elegans
Function: Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Has a role in regulating longevity, growth and brood size. May regulate fat storage via the insulin/IGF pathway.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:24552710}.
Interaction partners:
- Pescadillo homolog
- Nucleolar GTP-binding protein 2
- Ribosome biogenesis protein NSA2 homolog
- Guanine nucleotide-binding protein-like 3 homolog
- Probable ribosome biogenesis protein RLP24
- RRM domain-containing protein
- Ribosome biogenesis protein NOP53
- 26S rRNA
- Ribosome production factor 2 homolog
- ATP-dependent RNA helicase
Sequence:
MTSMYNFKRITCVPNAQELKDVVLSKTQRKTPTVVHRQYSIGRIRAFYARKIKFLQQTLHDKLTQIITEFPKMEEIHPFYSDLMNILYDRDHYKIALGQMNTARHLIDGIAREYVRLMKYADSLYRCKMLKRAALGRMVKLLKRQKSSFEYLEQVRQHLSRLPSIDPATRTLILCGFPNVGKSSFINNVTRADVEVQPYAFTTKALYVGHLDYRFLRWQVIDTPGILDQPLEDRNTIEMQAVTALAHLKASVLFMMDVSEQCDRSIEEQLHLFESIRPLFANKPVLIGLNKVDIRHRSDLPPEKAALLDQLEKEGIPIIETSTLTQEGVMGLRDRACDELLAQRVEAKIQAKKITNVEDCVLNRVFVAYPAPRDEKVRAPFVPPGLAAKRAQKKLQEAQELMETDGDEFAAKIPQKPGKIGKEKIAKGGSQSTDLGDLRDENTRRLEREIELEMQDDYILDLKKHYMLKNPDEKYDIVPEIWEGHNLADFVDPEIQSKLENLLREEELLEQAGEYESDLDSDDEETKEKLKLALQIREKEKLLTLDHAVNKRIAGRIGSRIHGSRKRDRSMSRLENELGELGVDVDTKKMKNLQGQCAKPQLGKKMKVGRSRSLSAVRPAPRDELAFPDEEKRAHVDKLRTKAMRGLRREAKKGEADRHVYDLKPKHLFCGKRGNGKTDWR
Protein: Neuropeptide Y receptor Y4 (Neuropeptide Y receptor type 4 isoform X1) (B3DIJ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Peptide YY-A
- Pro-neuropeptide Y
- X-ray radiation resistance-associated 1.
Sequence:
MPSALFDMPLWQALLNSTLTHNQSNSSLFLLDVPCWQSSTMTLTLVLCYCLVLILGLLGNILLICIIMHQRDPPNVTSILIANLSVSDILVSVFCLPFTVVYTLMDHWIFGALLCRLMPFVQCVSVTVSVLSLVLIALERHQLILHPSGWKPSVPQAYIAVLTVWLLACVTSLPFLAFHLLTSEPYSLFPAPLSQLQVCLEVWPSQEHKLAYTTSLLLFQYCCPLLLMLLCYLRIFLRLQRRERMLERQCSRNREDEHRRVMHSKRINVMLATLVAAFAVCWLPLNAFNVVADWHQEVLPVCNHNLLFSLCHLLAMSSTCVNPIIYGFLNSNFRKDVASVVLHCHFQPLEDSYEHFPMSTMNTDVSRTSFRLRNNSV
Protein: Eosinophil cationic protein 1 (ECP 1) (EC 3.1.27.-) (Eosinophil secondary granule ribonuclease 1) (EAR-1) (Ribonuclease 3-1) (RNase 3-1) (P97426)
Organism: Mus musculus (Mouse)
Function: Cytotoxin and helminthotoxin with ribonuclease activity. Possesses a wide variety of biological activities (By similarity).
Subcellular location: Cytoplasmic granule {ECO:0000250}. Note=Matrix of eosinophil's large specific granule. {ECO:0000250}.
Interaction partners:
- Ear6 protein
Sequence:
MGPKLLESRLCLLLLLGLVLMLASCLGQTPSQKFAIQHINNNTNLQCNVEMMRINRARRTCKGLNTFLHTSFANAVGVCGNPSGLCSDKRSQNCHNSSSRVHITVCNITSRATNYTQCRYQSRRSLEYYTVACDPRTPQDSPMYPVVPVHLDGTF
Protein: Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) (O43167)
Organism: Homo sapiens (Human)
Function: May be involved in BMP2-induced transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Lymphoid-specific helicase
- Cell division cycle-associated protein 7
- DNA
Sequence:
MAETSPEPSGQLVVHSDAHSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGYLHASEKSTEQILATAQFLKVYDLVKAYTDFQNNHSSPKPTTLNTAGAPVVVISNKKNDPPKRKRGRPKKVNTLQEEKSELAAEEEIQLRVNNSVQNRQNFVVKGDSGVLNEQIAAKEKEESEPTCEPSREEEMPVEKDENYDPKTEDGQASQSRYSKRRIWRSVKLKDYKLVGDQEDHGSAKRICGRRKRPGGPEARCKDCGKVFKYNHFLAIHQRSHTGERPFKCNECGKGFAQKHSLQVHTRMHTGERPYTCTVCSKALTTKHSLLEHMSLHSGQKSFTCDQCGKYFSQNRQLKSHYRVHTGHSLPECKDCHRKFMDVSQLKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRGEKPYSCGICGKSFSDSSAKRRHCILHTGKKPFSCPECNLQFARLDNLKAHLKIHSKEKHASDASSISGSSNTEEVRNILQLQPYQLSTSGEQEIQLLVTDSVHNINFMPGPSQGISIVTAESSQNMTADQAANLTLLTQQPEQLQNLILSAQQEQTEHIQSLNMIESQMGPSQTEPVHVITLSKETLEHLHAHQEQTEELHLATSTSDPAQHLQLTQEPGPPPPTHHVPQPTPLGQEQS