wanglab/gogpt-training-data huggingface dataset:
Protein: Anaphase-promoting complex subunit 7 (Cyclosome subunit 7) (Q8VY89)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 6
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 11
- Cell division cycle protein 27 homolog B
- Cell division cycle protein 27 homolog A
Sequence:
MEVPKEQIATLIEHGLYDSAEMLGCFLVSSPTVSAETSPQLKAENLILLGDALFHQREHRRAIHTYKQALHHYTRIPKQSSGISRSSLSLSTRSSVNASSISAINENEVRFKIASSHFALNETKAAIAEMESVKTRSLEMNILMAKLHRNSGYNRGAIAFYKECLRQCPYVLEAVIGLAELGVSAKDIISSFTQTSNRSAKVSLDQIDPTRWLQRYVEAQCCVASHAYKGALELFAELLQRFPNNVHLLTETAKVEAIIGKNDEAIMRFEKVRSIDPYTLTSMDEYAMLLQIKCDYSRLNKLVHDLLSVDHTRAEVFVALSVLWERKDARTALSYAEKSIRVDERHIPGYIMKGNLLLQAKRPEAAAIAFRAAQNLRSDLRSYQGLVHSYLAFGKTKEALYTAREAMNAMPQSAKALKLVGDVHAFTSSGREKAKKFYESGLRLEPGYLGAVLALAELHLMEGRNGDAVSLLERYLKDYADDSLHVKLAQVFAATNMLQDSLSHFQAALRINPQNEAAKKGLDRLEKQMKGIDPDATDENDENDVEDVDGDTEEAELM
Protein: Large ribosomal subunit protein eL30 (60S ribosomal protein L30) (Q9VJ19)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- 40S ribosomal protein S24
- Large ribosomal subunit protein P2
- Small ribosomal subunit protein eS4
- Ubiquitin-ribosomal protein eL40 fusion protein
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL43
- Large ribosomal subunit protein eL19
- Small ribosomal subunit protein eS26
- Small ribosomal subunit protein eS21
Sequence:
MVAVKKQKKALESTNARLALVMKSGKYCLGYKQTLKTLRQGKAKLVLIASNTPALRKSEIEYYAMLAKTEVQHYSGTNIELGTACGKYFRVCTLSITDPGDSDIIRSLETA
Protein: Complement component receptor 1-like protein (Complement C4b-binding protein CR-1-like protein) (Q2VPA4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14687939}. Membrane {ECO:0000269|PubMed:14687939}. Secreted {ECO:0000269|PubMed:14687939}. Note=Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.
Interaction partners:
- Complement C3
- Clusterin
- Complement C4-B
Sequence:
MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGAGSHDALIVGKFYEVFAEEFCHL
Protein: C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] (O96553)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Bifunctional purine biosynthesis protein ATIC
- Serine hydroxymethyltransferase
- Dihydrofolate reductase
- Methionyl-tRNA formyltransferase, mitochondrial
- Thymidylate synthase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
- Aminomethyltransferase
- GH04035p
- 10-formyltetrahydrofolate dehydrogenase
Sequence:
MSAQYQRFLKVLEKWPAEKSKVGSGEWTAEPAIKMSGAKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEGRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELLKWANATVTVCHSKTRNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLVGDVDYAEALQVAGHLTPVPGGVGPMTVAMLMKNTVRSAARFLERLAKSQWALQTLPLKPQRPVPSDIVIARAQKPKDIAVLAKEIGLEAREVSLYGNKKAKISLSVLERLKDKEVGHYVVVAGMTPTPLGEGKTTTLMGLVQALGAHKLRNTMAALRQPSQGPTFGIKGGAAGGGYAQVIPMEEFNLHLTGDIHAVSAANNLLAAQLDTRIFHENTQKDKALYDRLVPAIKGQRKFSPIQLRRLQKLGITKTDPDTLTADEYGPFARLDIDPDTIMWERVVDINDRYLRTITVGQSPTEKGISRETRFSISVASEIMAVLALSRSLEDMKQRLADMVVAFDKRGKPVTADDLGVTGALAVLLKDALEPNLMQSLEGTPVLVHAGPFANIAHGCNSIIADEVGLKLVGKNGFVCTEAGFGSDIGMEKFCNIKCRTSGRKPNAMVLVATVRAIKMHGGGAPVTPGAPLNKQYTEENLELVQKGLPNLLQHIENGKAFGMPVVVSLNAHSADTPAEHELVKKAALEAGAFAAVVSTHWADGGAGAVQLADAVIKACEQGNQFRLLYDLELPLVDKMNKIATTMYGAGKVVLSPAAEEKVKRLTDAGFGNLPICMSKVSGSFTGDAKIKGAPKGFTLDVEDVYVSAGAGFVVAMCGEVTKMPGLPTRPAIYDIDLNTETGEIEGLF
Protein: Homeobox protein B-H1 (Homeobox protein BarH1) (Q24255)
Organism: Drosophila melanogaster (Fruit fly)
Function: B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein B-H2
- BG1
Sequence:
MKDSMSILTQTPSEPNAAHPQLHHHLSTLQQQHHQHHLHYGLQPPAVAHSIHSTTTMSSGGSTTTASGIGKPNRSRFMINDILAGSAAAAFYKQQQHHQQLHHHNNNNNSGSSGGSSPAHSNNNNNINGDNCEASNVAGVGVLPSALHHPQPHPPTHPHTHPHALMHPHGKLGHFPPTAGGNGLNVAQYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVAAPPVDGGVDGGVGLAPPAGGDLDDSSDYHEENEDCDSGNMDDHSVCSNGGKDDDGNSVKSGSTSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNFAAFQRLYGGSPYLGAWPYAAAAGAAHGATPHTNIDIYYRQAAAAAAMQKPLPYNLYAGVPSVGVGVGVGVGPAPFSHLSASSSLSSLSSYYQSAAAAASAANPGGPHPVAPPPSVGGGSPPSGLVKPIPAHSASASPPPRPPSTPSPTLNPGSPPGRSVDSCSQSDDEDQIQV
Protein: Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) (Q15654)
Organism: Homo sapiens (Human)
Function: Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16624523}. Cell junction, focal adhesion {ECO:0000269|PubMed:16624523}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:16624523}. Cytoplasm {ECO:0000269|PubMed:16624523}. Note=Shuttles between nucleus and cytoplasm (PubMed:16624523). Colocalizes with actin (PubMed:10826496). {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:16624523}.
Interaction partners:
- Receptor-interacting serine/threonine-protein kinase 2
- Lysophosphatidic acid receptor 2
- Breast cancer anti-estrogen resistance protein 1
- Protein Mis18-beta
- Na
- Vinculin
- Exosome complex component RRP43
- Pyruvate kinase PKM
- Melanoma antigen preferentially expressed in tumors
- Enhancer of filamentation 1
Sequence:
MSGPTWLPPKQPEPARAPQGRAIPRGTPGPPPAHGAALQPHPRVNFCPLPSEQCYQAPGGPEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSSTLAELNGGRGHASRRPDRQAYEPPPPPAYRTGSLKPNPASPLPASPYGGPTPASYTTASTPAGPAFPVQVKVAQPVRGCGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGGEHGPQVPLSQPPEDELDRLTKKLVHDMNHPPSGEYFGQCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVATLEKCATCSQPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC
Protein: Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (VH1-related member Y) (Vaccinia virus VH1-related dual-specific protein phosphatase Y) (Q9H1R2)
Organism: Homo sapiens (Human)
Function: May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:15138252}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Lipid-anchor; Cytoplasmic side.
Interaction partners:
- Dual specificity protein phosphatase 23
Sequence:
MTEGVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR
Protein: AP-1 complex subunit beta-1 (Beta(1)-adaptin) (Beta-1-adaptin) (Clathrin assembly protein complex 1 beta-1 large chain) (Clathrin assembly protein large beta-1 chain) (O43079)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin (By similarity).
Subcellular location: Cell membrane {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.
Interaction partners:
- AP-1 complex subunit gamma-1
- AP-1 complex subunit mu-1
- AP-1 complex subunit sigma-1
- AP-2 complex subunit mu
- Probable clathrin heavy chain
- AP-2 complex subunit sigma
- AP-2 complex subunit alpha
- AP-3 complex subunit delta
- AP-3 complex subunit beta
- ENTH domain-containing protein C794.11c
Sequence:
MVPKLFQSSRFKAFKKSETSELQKGLVSQYAYERIDAVKRTIAAMTVGKDVSSLFPDVLKNLATRDITLKKLVYLYLINYAKTHPDLCILAVNTFVKDSEEYNPTLRALAIRTMGCIRVNKIIGYLADPLRKALKDEHPYVRKAAAVCVVKMYDLDREYCASNGFIEQLQALVSDPNPVVVANAVRSLAEIHDQDPEKGYFNVVYTMTDRLMVALSECNEWGRITILNSLARFRTSDIKEAEYVCERVVPQFQHANSGVVLSAVKVIMVHIPLFSSDFTDFLYKKMAPPLLTLLSTDSEIQYVALRNINLILQKRPSIFDVKTRVFFCKYNDPLYIKMEKLKIITMLACDENINETISELRAYVSEVELEFVKQTIKCLGDVALKVPSVINDCISIFLEIYELNISYMVQEVTVVMETVLRKYPQKIDLLLPYLSRVIEELGDPRARSSMAWILGEFSHVIPTSSKLLSEMISTMADEDLQIQLALLTAVVKLSLMNGKGNDEELVQKVLNYAINQSSNQDLRDRAFAYQRLLTPENVRKAQKIVCCEKPSVSYNNNLPEALLDALLCEITTLASVYHKLPESFIGQGKFGADAIQRRAVEELNIEEANVHEAIEKGANVENLLDLDFTDPGATSASDSPITSAQPQSGSNSAMDLFMAFEAPSTNNAEPVKARSATDDLLGL
Protein: Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Q5LRA7)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Pyruvate dehydrogenase E1 component subunit beta
- Acetyltransferase component of pyruvate dehydrogenase complex
- 2-oxoglutarate dehydrogenase E1 component
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
- Pyruvate dehydrogenase E1 component subunit alpha
- Glycine cleavage system H protein
- 2-oxoglutarate dehydrogenase E1 component
- Aminomethyl transferase family protein
- Aminomethyl transferase family protein
- Trimethylamine-oxide aldolase
Sequence:
MAAQSYDVIVIGAGPGGYVAAIRAAQLGLKACVVEREHLGGICLNWGCIPTKALLRSSEVFHLMERAKEFGLKADNIGYDLDAVVKRSRGVAKQLSGGIGHLMKKNKIDVVMGEATIPAKGKVSVKTDKGTQELTAKNIILATGARARELPGLEADGDLVWTYKHALQPVRMPKKLLVIGSGAIGIEFASFYNTLGADTTVVEVMDRVLPVEDAEISAFAKKSFVKQGMKIMEKSMVKQLDRAKGKVTAHIETGGKVEKLEFDTVISAVGIVGNVENLGLEALGVKIDRTHVVTDAYCRTGVEGLYAIGDIAGAPWLAHKASHEGVMVAELIAGKHAHPVKPESIAGCTYCHPQVASVGYTEAKAKELGYDIKVGRFPFIGNGKAIALGEVEGMIKTIFDAKTGELLGAHMVGAEVTEMIQGYVVGRQLETTEEDLMHTVFPHPTLSEMMHESVLDAYGRVIHM
Protein: Mediator of RNA polymerase II transcription subunit 13 (Mediator complex subunit 13) (Q5ALX5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 12
- RNA polymerase II holoenzyme cyclin-like subunit
- Serine/threonine-protein kinase SSN3
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 19
Sequence:
MVGANASSISTQYYKLAHLGSISYTIYTSSDNNDQALLELELTIRHKWPQILVTYYNKSLYYFVFGHNKVDSETIDLTKEFPQLSTKYTDTVNVDQFPNPHKSTKNDDNLAWASLSFLKATKKMILYNLSLSGAIKLFGNYCVAPTGDSVYSILCIDPILFQNGDLVVSCVEKPFTQLFSSSVAYPRNLAIDTNFVIYLIPSGIRCHLFDPTSLRNNLIEKPQIENGKLLELLKITTGVQCDESTLWVKLIPNLKHLNNQTSAIGKFIHSVENKKFILWPWDLCLLQFGKFEPAIEEEGLLESSELNNPLHLISDFLDFRIAHNTQLQQQRDSLSDQQQGETVNVPLSAGSVHATGANSFGNVPDISKDVDTVGLSTTTPIETDLFNLQNTEEFFKNDSIHMNLEDQIHKKETEPENESENDMEIDDLFGGDESDDNDDLEEAGNEEEKPTPSNNTIDKNGVIGNALEEAFIADATPSKENINLDSKIMPPDSTSEEAVPDKENFKPKETKPSYIDILKDKMTIEKIVNSPDYKDPGAPLPVVPTPLVSSTVSQSAVTTNPPSVGSAPGPAPGPAPGTETLYEANNAYAQSSQISQLPQQKSAFSPILFNPIIKSDIDTKYGKGGKFYVAKDSSTNGNLDMKNRSLRATSVSGMEIPFSSEDKKRLQQNLEVLDSSTTSDNEGGEDIEDDDNDYEDEGDDDEEEEGEEEEEEESDEDEISDIGKSTPLKLNTQNESVPPQQSNYNPVNITDSGSNTTNNITDKQGYENTEGFGTPFPNQISKYSIKPESPFASNELQSSVSPMYFDTSQSHQSPQLQPSTGTLEVLKASSLESPSKISESSNYLPLILRSINVSTIPSSYLMNNLISSKLLPSFTISDDDLENDLDITKSNEMIVKLGFLKEFLDFMSPNIIFDLGLMKNDESDYYINGVNDLLLNSDPGISSDWILNSLSKVFPCTYPMKLIELLYDFKSLELEDQLDSQLNFLNEIADEEDFVGPKALYRKLKALEWDSFSLNESNKTSFEKYKNVMEKLSAENTVSDDDYFKLPMVKTRILKNGNIVNLNNIGLKFWKYLNFSPVKKQKDFQILLIAETHRNTASYATEFLDQIIQNYKECNFGTISKVNLSTVETRSDLEPISDGLVLVHKEHDQSYNDFYIQTNKKLISLVELIKLDLINKTNNFEFGKPLLLFFIDFNDSSNSNVQVCKIFRNFKVALTTHQLPLVDIFTKIVPSSLLVKKVHHETALKVFSNYKLTKISMNLYNECPNDLANKSIVKNLFTTIVKDPPSKIQFKFMNSSYRDNSSNDDIFLHLAYERSIDNSWFVASWSDPLGRVVHVKSWYCSDSVSKSEKSTYRGDIMDIMSITDDIWSISTDLFKVLNDELGSFGGKKFLVLTRINSIIPDVELVHWKRLSSKHKEISLIVVSVRQTPRIVGSNESEDLGPKSNDYAPTPMIQDKDIFFGFKQTFSTSNTSSPSASGGALVTSPNSLSLHSPQQFLNAPANFLSPQDLIAPTSSGISGAKPGSSGIDPEVVLENQDNEVYGVIPKVPLPSFNSPTRFCMKTGYLMMQVNQPSEEEYKDDIKKTYLVYEINLLSCSNYWNLDVLMKLIMSQYKQMIALNDILCMNPIVGESDILGTHSRNNAIVPWHINAVGKLLDYLVHIYVDKD
Protein: DNA-binding response regulator (GacA) (Q6U738)
Organism: Aliivibrio fischeri (Vibrio fischeri)
Interaction partners:
Sequence:
MIKVFLVDDHELVRTGIRRILEDVRGIKVVGEADSGEDAVKWCRTEQADIVLMDMNMPGIGGLEATKKILRFNPDVKVIVLTIHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRMVQSGQRYLSPEIAQQMALSQFTPDAENPFKELSERELQIMMMITKGEKVTDISEQLNLSPKTVNSYRYRLFSKLNISGDVELTHLAIRHGILDAETL
Protein: Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Q19848)
Organism: Caenorhabditis elegans
Function: Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of anchor cell invasion through the basement membranes separating vulval and somatic gonadal cells during the L3 larval stage.
Subcellular location: Nucleus {ECO:0000269|PubMed:17170708, ECO:0000269|PubMed:20599896}. Cytoplasm {ECO:0000250|UniProtKB:Q99986}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q99986}. Note=Nuclear during interphase, accumulates at the nuclear rim in prophase and localizes to chromatin throughout metaphase, anaphase and telophase. {ECO:0000269|PubMed:17170708, ECO:0000269|PubMed:20599896}.
Interaction partners:
- Ankyrin repeat and LEM domain-containing protein 2 homolog
- Barrier-to-autointegration factor 1
- tRNA-intron lyase
- Ras-like GTP-binding protein rhoA
Sequence:
MPPKKAPAKKLHELAAEVRVGHKINDISKKTFIVGKQFATGGFGRIHTCTEEGKSQQMVMKIEPSTNGPLLTEVVVFNRILKKELIESYKKKKKISWIGLPYLIANGYFTYESEKMRYMIIPKYATSLEAVRETNGGTLAMKDSLTVASCILDALEYLHESDYAHADVKAANILLEKQGVYSTAVLVDFGLAHRTTNNVDKPDKKRAHNGTCIFTSTDAHRGNNPSFRGDIEILAYNLMMWATGTLPWMALESSPEKVFDAKQKFIAGLPGTLQNVLKNESSAVVGCIASMFDISMKTNYTDKVDMGKLKKLVTDAIQKTSSDGKKTPTRQKKLAEEDKNAVTPKRSTRRLAVKEESDNKDNDEVEVKPEKKATPRKRTTRKAVEVNNDSDDNEEQYENPKSKSSRTQTKSKRAKEEDVDDEEEIIIPKSSRSRSKVQLSGEGSDVTTPSSAASTSRSRSIRLGLTSSTASSNKVAKKIEQKYKRLSMNKSSLVPVTISVASDKSPTTSTPSSSSGLRSKRKSSEDVGEGITLKTQVLITPAIKKAKTKSGISSATKASPTELRRVPGVRNFPKGRRSMIIKETSAKYKERLASRQTKPTFDDSSCSSEV
Protein: NADH dehydrogenase subunit 5 (Q8DKX9)
Organism: Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Membrane {ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000320}.
Interaction partners:
- NAD
- NAD
- NADH-quinone oxidoreductase subunit J
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- NAD
Sequence:
MEPLYQYAWLIPVLPLLGALIVGFGLIAFSETTSKLRRPSAIFIMALMAIAMGHSLTLFWSQVQGHLPYTQMIEWAAAGNLHIAMGYVIDPLAALMLVIVTTVAFLVMLYSDGYMAHDPGYVRFFAYLSLFGSSMLGLVVSPNLVQVYIFWELVGMCSYLLIGFWYDRKSAAEAAQKAFVTNRVGDFGLLLGMVGLFWATGTFDFAGMGDRLTELVNTGLLSPSLAAILAILVFLGPVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGVFLIARMFPVFEQLPQVMTTIAWTGAFTAFMGATIAITQNDIKKSLAYSTISQLGYMVMGMGVGAYSAGLFHLMTHAYFKAMLFLGSGSVIHSMEGVVGHNPDLAQDMRYMGGLRKYMPITGATFLVGCLAISGVPPFAGFWSKDEILGAVFHANPAMWLLTWLTAGLTAFYMFRMYFMTFEGKFRNVPPERQEHHDHHSHHAAVPHESPWTMTLPLVVLAIPSTLIGFVGTPFNNLFEVFIHAPGEEKVAEHAVDLTEFLILGGSSVGIGLMGITVAYLMYLKGTPSPQAIAKAIQPLYQFSLHKWYFDELYEAVFIKGCRRLARQVLEVDYNVVDGVVNLTGFVTMVTGEGLKYLQNGRAQFYALIVLLAVLGFVIFSVQT
Protein: T-box transcription factor TBX15 (T-box protein 15) (T-box transcription factor TBX14) (T-box protein 14) (Q96SF7)
Organism: Homo sapiens (Human)
Function: Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Interaction partners:
- Tryptophan--tRNA ligase, mitochondrial
Sequence:
MSERRRSAVALSSRAHAFSVEALIGSNKKRKLRDWEEKGLDLSMEALSPAGPLGDTEDAAAHGLEPHPDSEQSTGSDSEVLTERTSCSFSTHTDLASGAAGPVPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTTSATQPSETFMPQRTPSLISGIPTPPSLPGNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPSGMEHSMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVHMV
Protein: Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) (Q99704)
Organism: Homo sapiens (Human)
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Subcellular location: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, perinuclear region.
Interaction partners:
- Ras GTPase-activating protein 1
- Tyrosine-protein kinase ABL1
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Protein-tyrosine kinase 6
- Tyrosine-protein kinase CSK
- SH2/SH3 adapter protein NCK1
- Cytoplasmic protein NCK2
- Crk-like protein
- Envoplakin
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Sequence:
MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFPKGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPLDSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST
Protein: Centrosomal protein 44 kDa (Q54SG2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MSGVALNSKTWGKSLIYHRKMMNAEYKNGMKRLSFLAEERHVQYREEYIQNVRDRIAKNKEHMDQQNKIIKDLNSRSNNRKNLISMGWESLKTQMAEEKKQRKENSKLIFEKTKLLQDRARREWLIEMNDKCTTWNKSPNELKYAKYRLLNKKVLERIPRGGNYVLDLHEQPNNNQIFESTDDYSGPLRSNTQRLAHILSKTGVADFDSILMKNNNKNNVDNNNINNIDNLEVDPSSPDYPEYLEFLKFNKQLEENRQKHIRDSNQGKSSLFHESLNSENVLKNYTSGIDYDHITDEILTFTDLSQDTDSHDFYREIEEEIHEEESRLREEARLVEEDAIEEEGAIEEDAIEDDYSVEDDYSVEEETEDHKN
Protein: Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) (OF45) (Osteoregulin) (Q9NQ76)
Organism: Homo sapiens (Human)
Function: Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11414762, ECO:0000269|PubMed:15108058}. Secreted {ECO:0000269|PubMed:37453717}.
Interaction partners:
- Dentin matrix acidic phosphoprotein 1
- Dentin sialophosphoprotein
- Phosphate-regulating neutral endopeptidase PHEX
- Osteopontin
- Fibroblast growth factor 23
- Extracellular serine/threonine protein kinase FAM20C
- Sclerostin
- Integrin-binding sialoprotein
- Secreted frizzled-related protein 4
Sequence:
MRVFCVGLLLFSVTWAAPTFQPQTEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQELSSKENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESDGD