wanglab/gogpt-training-data huggingface dataset:
Protein: Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6) (Q9JI12)
Organism: Rattus norvegicus (Rat)
Function: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular L-glutamate uptake. The vesicular H(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic. Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine L-glutamatergic system of other tissues such as pineal gland and pancreas.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:11502256, ECO:0000269|PubMed:11551935, ECO:0000269|PubMed:11698619, ECO:0000269|PubMed:11698620}; Multi-pass membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000269|PubMed:11502256, ECO:0000269|PubMed:11698619}. Cell membrane {ECO:0000269|PubMed:18080752}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Vesicular inhibitory amino acid transporter
- Vesicular acetylcholine transporter
- Synaptic vesicular amine transporter
- Chromaffin granule amine transporter
- Vesicular glutamate transporter 1
- Glutamate decarboxylase 1
- Vesicular glutamate transporter 3
- Glutamate decarboxylase 2
- Disks large homolog 4
- Calretinin
Sequence:
MESVKQRILAPGKEGIKNFAGKSLGQIYRVLEKKQDNRETIELTEDGKPLEVPEKKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATSQENGGWPNGWEKKEEFVQESAQDAYSYKDRDDYS
Protein: Hypothetical membrane associated protein (Q0KFC8)
Organism: Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha)
Interaction partners:
- Phasin
- Predicted esterase of the alpha-beta hydrolase superfamily
- DUF2069 domain-containing protein
- histidine kinase
Sequence:
MFGQIPDFTNGFDFMRRLWGSGSGMPAGMMPGLQAMTPPMDLDDLDKRIADLKAVESWLQLNTNLLRTTIQGLEVQRATLVALQTFGNALSPEAMQSAMENVARAANTPSAAAPERDAGADADSGTQQEPPAAERPQAAASDTDSALPPNAALWWDLLQQQFNQIASSAAAASIAPFGMGGVGGFGTAASPDAAAQAAAAKPKTDAPGKAASAGTGKPAARKAPAKKAPAKKAAKAKPARDAGNGEDNGKNGGNNGANGSSAA
Protein: Ubiquitin-conjugating enzyme E2 ubc-18 (EC 2.3.2.23) (Q21633)
Organism: Caenorhabditis elegans
Function: Ubiquitin-conjugating enzyme E2. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Required for diet restriction-mediated lifespan extension, probably acting as part of a complex with ubiquitin-protein ligase wwp-1. Acts redundantly with lin-35/Rb in the regulation of pharyngeal morphogenesis during embryonic development by negatively regulating the expression of proteins such as sup-35.
Interaction partners:
- E3 ubiquitin-protein ligase wwp-1
- E3 ubiquitin-protein ligase ari-1.1
- E1 ubiquitin-activating enzyme
- Ubiquitin-like domain-containing protein
- UBC core domain-containing protein
- GDP-L-fucose synthase
- Retinoblastoma-like protein homolog lin-35
- RBR-type E3 ubiquitin transferase
- C2H2-type domain-containing protein
- Ubiquitin-conjugating enzyme E2 variant 1
Sequence:
MSATRRLQKELGDLKNCGVKAYENVECEETNLLKWTVLLIPDKEPYNKGAFKVGITFPVDYPFKPPKVAFETKIYHPNVDEEGKFCLPIVTAENWKPATKTEQVMMALLSLINEPEPSHPIRADVAEEFQKDHKKFMKTAEEHTRKHAEKRPE
Protein: BcDNA.GH12504 (Q9Y0Z8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MYMQHERHSDSDPNSRHQQTEASHMRDHWKPSKSQQSQQSDRVDPHDKPSQTAVSFLQKHHTPKNPESKANPDDGASCSCTAKRSKSADPPAVKAHTCACNTDPSPCGLGHQEKSSSRKPCSQKTSVTEPEKASSFKSAITACTKELLDPCTCGAHPPYWAGQSNLVTGPSYSRAMDPSSSTLAPLHRPGASKGSFGRSKSLASLPSKSNPPTQSGVTWLSALKDPESTCCSSKEDERPACTCNATQTNQDPSMSSLPQSHPNYRSMTSKSSNFRAPNPRNQPSFGPGDETSATTRSQSIVGQVTCLCASEHQPTKAFVSSLADRECPNEIQIAPCPSTRIHHPSGFAQFTDCQNSQGDPSTSFRSRKVSVKGQEEFCDCDASDNFSELSDPIQTSLHTHRSLSGGSCLCNDDADPPKEPEKATCVSKQCQCSSNDELQGMQSAQAGTGYQTPEDLCGNRAMACCSRKERILMLMEKLTSPGCDCGISRPCLTQQLFRELTLLLRSEKDDAVAPADEASPPCLTFDECCTAQHAGNGEGDPVEKPPSKRELQRVECFHQLEEYLCKCFLPPAEPQIPETDIYAFELDPDFPPEPEPKSPKENDNMQPCQCPEQFFDIGNALTCSGDGLDDDFFRDCEDDEEVKKFESKDDGKATTEPDLCQSLKAFIDKELQEILAEEANKEGEEVEEKTPSTVLREICERPTTVASPEEEEKPEQIECPFAGMVSCPPWTTQQTDWAAFPYNLDPCAQKESPSPAPRGPRTGLLPEGPLSPDMRNLCEQLLRKALKDCGLCGGDDVYSCEDDVCEECALNCEECPEDCPLEKCEECDDECPPEQQGCLCCHCRLSYATRSARRLPIPCAPECVIHSAK
Protein: 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12) (Q9R1Z7)
Organism: Mus musculus (Mouse)
Function: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
Interaction partners:
- Sepiapterin reductase
- GTP cyclohydrolase 1
- Aldo-keto reductase family 1 member B1
- Carbonyl reductase 1])
- aldose reductase
- Aldose reductase-related protein 2
- Aldo-keto reductase family 1 member B7
- Intestinal-type alkaline phosphatase
- Alkaline phosphatase
- Alkaline phosphatase, tissue-nonspecific isozyme
Sequence:
MSAAGDLRRRARLSRLVSFSASHRLHSPSLSDEENLRVFGKCNNPNGHGHNYKVVVTVHGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADAVSTTENVAVYIWESLQKLLPVGALYKVKVFETDNNIVVYKGE
Protein: Membrane lipoprotein (Q6E248)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- NDR1/HIN1-like protein 6
- Increased DNA methylation 2
- Extra-large guanine nucleotide-binding protein 3
- Extra-large guanine nucleotide-binding protein 2
- Increased DNA methylation 1
Sequence:
MARHLLEDVMSMATTTTHFDASYLFHVVFLAVIGCCILSALLFSCADGVSDNRATSGTSTGGGGCGGAGCGGGCGG
Protein: Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form] (Q13683)
Organism: Homo sapiens (Human)
Function: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Integrin beta-1
- Laminin subunit alpha-2
- Laminin subunit alpha-4
- Fibronectin
- Integrin beta-5
- Integrin beta-4
- Laminin subunit alpha-1
- Focal adhesion kinase 1
- Talin-1
- Talin-2
Sequence:
MAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGLLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPMDVDGTTALFALSGQPVIGLELMVTNLPSDPAQPQADGDDAHEAQLLVMLPDSLHYSGVRALDPAEKPLCLSNENASHVECELGNPMKRGAQVTFYLILSTSGISIETTELEVELLLATISEQELHPVSARARVFIELPLSIAGMAIPQQLFFSGVVRGERAMQSERDVGSKVKYEVTVSNQGQSLRTLGSAFLNIMWPHEIANGKWLLYPMQVELEGGQGPGQKGLCSPRPNILHLDVDSRDRRRRELEPPEQQEPGERQEPSMSWWPVSSAEKKKNITLDCARGTANCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYSAVKSLEVIVRANITVKSSIKNLMLRDASTVIPVMVYLDPMAVVAEGVPWWVILLAVLAGLLVLALLVLLLWKMGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDAHPILAADGHPELGPDGHPGPGTA
Protein: Uncharacterized protein, isoform B (A1ZBB4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDVAKLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVTPSRRQRRTRSMSRSPSPVQAAPVAAEPVLDTLEEEEQPEDKTVPQPEPESEQPAAEPEPEQSEPEEAEPAAAVTEDTTVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPMEEDHDAAPEEQEPTQTEEPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEPAAKPEDQPPERRKRSHSRSKSRSRSGSRSSKHRGSVGDKRESKAAAEERTVPEDEPTIEENKVGLSWLDSDLHLRIDPTTFASAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSEESVPENSHYFRDEPHVRGFRVGFSMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLESEPCTINYTLNGEDLGVAFEFEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERPTRKRRKPRKDEDKDKDDDKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAALLEGYVLIGLVPVEKLVSGPQRVGSRKECEVILLVGLPGAGKTHWAHKHVAENADKRYELIGPDAFISKMTIDGASRKTVHKGRWDKVYEICLNSLAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFNDFKRIAVVCIPSEDELKRRIAEKEEKGNAFTVKESTINNLRANFTLPSLEFGWFDDINYTELTGDEAKSEVKKYNEKGKKAIDAERSRDKRSRGSRDNYRRDDRNRNRYNDDRRRDYGGQRHESRWSDSRRGGGGGGYSSNSGGGGSRGYDNRRNYNSGSGGQQNWVQNSRRSGYDDRGYGGGGSGSRGYDNRNRGYAGGSGGGGGGGGGGGGGGGQQNWMQNNRRSGYDDRGYGSSRDYRDRDRGNDRSRMGSNDRNRGSSQSSYRSGGGTHQQRDFRPGHRDTKEDSRGGYERSAGQSLPKYGNNTAVGGGYDQYKQQGGAPGGGKASLSGKWSTYSQHHQQQQAPQHQQTGIWQTQQQSQQYQQPQQAAAGQQQYWAYNQMQSYGNQQAWQSADPQQQQQWMSWWQQQQQGSGGAAAGNASGGSGVNVGGGAGNNDGGAANHYWSQYSYSTQSNAGADKK
Protein: E3 ubiquitin-protein ligase XB3 (EC 2.3.2.27) (Ankyrin repeat domain and RING finger-containing protein XB3) (RING-type E3 ubiquitin transferase XB3) (XA21-binding protein 3) (Q65XV2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: E3 ubiquitin-protein ligase required for full accumulation of the LRR receptor kinase XA21 and XA21-mediated disease resistance. Binding to XA21 may stabilize the receptor kinase and maintain its protein level. Autoubiquitinated in vitro.
Interaction partners:
- Receptor kinase-like protein Xa21
- Os01g0314700 protein
- Kinesin-like protein KIN-14I
- Ankyrin
- Probable E3 ubiquitin-protein ligase XBOS34
Sequence:
MGHGVSCARTGDEHDFFRAAQLGDLDALAALLAADPSLARRATLYDRLSVLHIAAANGRIEVLSMFLDRGAPPDAVNRHKQTPLMLAAMHGKIDCVLKLLQADANILMFDSVHARTCLHHAAYYGHVDCLQAILAAAQTTPVADSWGFARFVNVRDDHGATPLHLAARQGRPGCVQVLLENGAIVSALTGSYGFPGSTSLHLAARSGNLDCIRKLLAWGADRLQRDSAGRIPYSVALKRNHGACAALLNPTSAEPMVWPSPLKFISELEPEAKALLEAALMEANREREKKILNGTKYSLPSPSPGDDSADDDACSEVSDTELCCICFDQACTIEVQDCGHQMCAPCTLALCCHNKPNPTTLTPPSPACPFCRGSISRLVVAQTRSACDPDKPSSLQLTRKRSRRSHNLSEGSSSFKGLPSAMGSFSKLGRGSSRMADSDSSNLDKPEHDL
Protein: Sperm-egg fusion protein TMEM95 (Transmembrane protein 95) (P0DJF3)
Organism: Mus musculus (Mouse)
Function: Sperm protein required for fusion of sperm with the egg membrane during fertilization.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:32484434}; Single-pass type I membrane protein {ECO:0000305}. Note=Following the acrosome reaction, relocalizes to the equatorial segment. {ECO:0000269|PubMed:32484434}.
Interaction partners:
- Izumo sperm-egg fusion protein 1
- Sperm acrosome membrane-associated protein 6
- E3 ubiquitin-protein ligase DCST1
- Cilia- and flagella-associated protein 119
- Armadillo repeat-containing protein 3
- DC-STAMP domain-containing protein 2
- Fertilization-influencing membrane protein
Sequence:
MWVLALGGAFLAVAKACIFCRLQDHALANRLAQLNNQTKPKWKWKEWASPDFSAFALDEVSMKQVTEKTHRVLRVIEKKGSTSLIPLYWQWLQKTRIPQYTREALCAPVCRGSTILYNCSTCEGKEESCWPQKHCYPDSHDLWDARILLLCIFGIVLLSGVVSLQVEYLNLQAKDL
Protein: Cyclic AMP receptor protein (Q9KNW6)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Interaction partners:
- Adenylate cyclase
- RNA polymerase sigma factor RpoD
- Glutamate synthase large chain
- Glutamate synthase large chain
- Pyruvate-flavoredoxin oxidoreductase
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit beta
- Aerobic respiration control sensor protein
- diguanylate cyclase
- histidine kinase
Sequence:
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHAGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERTAWVRAKTPCEVAEISFKKFRQLIQVNPDILMRLSGQMARRLQVTSQKVGDLAFLDVTGRIAQTLLNLARQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEEQNLISAHGKTIVVYGTR
Protein: Y' element ATP-dependent helicase protein 1 copy 6 (EC 3.6.4.12) (P53819)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Interaction partners:
- Uncharacterized protein YHL050C
- Y' element ATP-dependent helicase YIL177C
- Y' element ATP-dependent helicase YJL225C
- Y' element ATP-dependent helicase protein 1 copy 4
- Putative UPF0320 protein YNL337W
- Putative uncharacterized membrane protein YBL062W
Sequence:
MEIENEQICTCIAQILHLLNSLIITFLDDDKTETGQSFVYIDGFLVKKHNNQHTIVNFETYKNKMKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPDFQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCYEIASARPNDSSTMRTFTDFVSGTPIVRGLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETALKDSYRITLVPSSDGVSVCGKLFNREYVRGFYFACKAQFDNLWEELNDCFYMPTVVDIASLILRNREVLFREPKRGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMIHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKFFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDILLCRDSSREVGE
Protein: Glucan 1,3-beta-glucosidase 2 (EC 3.2.1.58) (Exo-1,3-beta-glucanase 2) (Q10444)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Glucan 1,3-beta-glucosidase 1
- Glucan 1,3-beta-glucosidase 3
- 1,3-beta-glucan synthase component bgs4
- Glucan 1,3-beta-glucosidase
- Putative beta-glucosidase
- Alpha-glucosidase
- 1,3-beta-glucan synthase component bgs2
- 1,3-beta-glucan synthase component bgs3
- 1,3-beta-glucan synthase component bgs1
- Uncharacterized family 31 glucosidase C1039.11c
Sequence:
MSNLLEAESSCDSKSLGVDDFTSKRCREIDKKALLITILLTFFVSLCVFLSIILPLIFLVIIPHAQSDRKIKDTNMETTNLGVNIIDEIFNSTQVPEWAKNSLLDTNTWLDTSDFNTSFTNETFAGLYTMGIFDKYDDSVQANPNVPPLNEPFPYGRLPIRGVNLGGWLSMEPFITPSFFQVKNETAYLVKDELSLHAYLGENATSVIENHYNTFVTKQTFYEIREAGLDHVRITFPYWILYSNEITNVSGIGWRYLLRSIEWAREQGLRVNLDLHAAPGNQNSWNHGGYLNQMEWLDGTVKGEENSQFTLKIHERLASFFSQKRYRNVVTIYGALNEPNFFVLDEHKITDWHKQAYAVIRQSNFTGLISLSDGFRGPGNWEDHFDPFHFPNILIDVHRYIIFNDFLIGLRPKDKLNVICKSWNEEMKLKAKLPTIIGEWSLADTDCAKFLNNVGEGARWDGTFTPNGGVASCSEKVGCRCDFANQDPENYEDSYRKFLYALATSQIETFDKTWGWFYWNWDTENATQWSYKKSWLAGLLPRLAYSTTKDFNCSMLDSKSFMEFDEQSEF
Protein: Meiotic driver SPOK1 (Spore killer 1) (A0A447CCJ8)
Organism: Podospora comata
Function: Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system, leading to poisoning of progeny that do not inherit the allele. Can suppress meiotic drive by the P.anserina SPOK2, SPOK3 and SPOK4 proteins.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:B2AFA8}. Nucleus {ECO:0000250|UniProtKB:B2AFA8}.
Interaction partners:
Sequence:
MSDKDRIAQLLRELEEAKARVEEAKAREAQERCEKERLQLEHRKTTFLEYLRNCHRHLYNALRLTDTSRSSTGYTKVVGKYYPKRLRPWTNFANVLHPRYFDLVQKICGQRQLFEPASTTKNLGTIISDHLAGNEKAIDRFEVDAVERPVQAILKVLATHEEAGKAYRCPEFRFSANLRELTQEDDGSSGADDNTSDGSLERRQQAGPNKRPTSKRKYICSNRQPDGVGIRMQPGGGQTQAFIYDYKAAHKVAIEHVRSATAKEHLFHEVVARINDNKLSRDKEVQRREQAEAFIAMALTQVFDYMITYGVSYGYVAAGRCLLLLYVDRDDWQTLYCHPCLPADDVGEPTNDWTDRLSHTAVAQLVSFCLSSFQSEALEGQSLETALSVANATLKTWSESYADVAYLGLEPAELSSAPSSQNTDISEYTSKAKPTGRNVALRSQSSCKPAAVLPQGNEHDEHDEDHSEPGASRSRLAANKRKRGPSSGGEDEDIAMADPEPTRQYCTQACLLGLKRGKDLDENCPNVSLHRFDGSSRHPVNAHRFTDMVKQQLLLSPYKGCRMVDFWGKRGAMGWLFKLELFPYGYTFVGKGTLEDRLSRLEHEGRVYARLDHLQGDVVPVHLGLVRLDRGYILPGLEFVVYMMLMSWAGQTPSASMADAETLKRESLTAIWSEGVDHGDDNRANYLWNAERCRIMIIDFDRARLFPPLKPRAVSRLSKPKRERGNRSRHQIRT
Protein: Pickpocket 23, isoform A (Q9VX46)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPQEKRHPPESRTQRFLETLVIFRRSLIYQTKEFFQNSTLHGVRYIAESGRPIGEKFMWFCFTSIGAVTALVIIMSLWEKFQTNPTITGLDTDFHNQNVVFPTTVVCPEAAFDHDKTYEKVYNTLANYDEAQAQMYTPFLRILTSLNFENVRDAKVLSQSIPQNLLDAHTIREWAFEGHIDCKNVFVSCKYRDEDIPCCDHFEPIYTEHGFCYAFNSRFKSTPTEDVKTGAPHDLYETDKKWALFFIPNSTSRIFIFSNEEYFGSDFNAQIDWSEPQLVEVRISKKNTYTTDDARQLSIGQRKCIFSDEVKLNYFPDAYTFSSCMKQCRMNKAIKLCKCNPPFYKPIPNVPMCSIKDFDCLDEFKSNITNIKDCLQCELSCSKTVFNIDKLIKMSDRPESLGVLVEFLTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEIIYYFTLRACCMVYKNRVNYANRIFQSTSI
Protein: Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (PbeIF2alpha) (A0A509AJP9)
Organism: Plasmodium berghei (strain Anka)
Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity). May regulate protein translation in response to amino acid starvation (By similarity). May regulate protein at various stages of parasite development (Probable).
Subcellular location: Cytoplasm, Stress granule {ECO:0000269|PubMed:20584882}. Note=When phosphorylated at Ser-59, localizes to stress granules in schizonts and male and female gametocytes (By similarity). When phosphorylated at Ser-59, localizes to stress granules in mosquito salivary glands (PubMed:20584882). {ECO:0000250|UniProtKB:Q8IBH7, ECO:0000269|PubMed:20584882}.
Interaction partners:
- 40S ribosomal protein S30
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 4C
- Translation initiation factor eIF2B subunit epsilon
- Eukaryotic translation initiation factor 3 subunit I
- Small ribosomal subunit protein eS1
- Eukaryotic translation initiation factor 2 subunit beta, putative
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit alpha
- 40S ribosomal protein S3
Sequence:
MGDARSKTDLGDCRFYEKKFPEVDDLIMVKVNRIEDMGAYVSILEYNDMEGMILMSELSKRRFRSVNKLIRVGRHEVVLVLRVDNQKGYIDLSKRRVSPKDIIKCEEHFSKSKKVHQTVRHVAQKHNMTVEELNRKVIWPLYKKYGHALDALKEATMNPDIIFKEMDISDAVKESLLSDIKLRLTPQALKLRGRIDVWCFGYEGIDAVKEALKKGKEISNNEVTINIKLIAPPQYVIVTSCHDKELGMQKIQEAMKVISDKIKEYKGGDFKQQGEILVIGGDDEKRLEELLDKHDGLSSDDEYSSDGDEDDSSNDDDNSSDEDDDD
Protein: Beta-lactamase (EC 3.5.2.6) (Cephalosporinase) (CSase) (P00811)
Organism: Escherichia coli (strain K12)
Function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
Subcellular location: Periplasm {ECO:0000303|PubMed:6795623}.
Interaction partners:
- Outer membrane lipoprotein Blc
- 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
- Anhydromuropeptide permease
- Peptidoglycan D,D-transpeptidase FtsI
- Peptidoglycan D,D-transpeptidase MrdA
- D-alanyl-D-alanine carboxypeptidase DacB
- DNA gyrase subunit A
- Penicillin-binding protein 1A
- D-alanyl-D-alanine carboxypeptidase DacA
- DNA topoisomerase 4 subunit A
Sequence:
MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ
Protein: Nuclear autoantigenic sperm protein (E9PPR5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAMESTATAAVAAELVSADKIEDVPAPSTSADKVERGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAE
Protein: Ras-related small GTP-binding family protein (SGP1 monomeric G-protein) (Q9SUJ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- non-specific serine/threonine protein kinase
- Protein NRDE2 homolog
- At3g17740
- Kinesin-like protein KIN-14E
- Ypt/Rab-GAP domain of gyp1p superfamily protein
- Ypt/Rab-GAP domain of gyp1p superfamily protein
- Ypt/Rab-GAP domain of gyp1p superfamily protein
- At3g07890
Sequence:
MAEKVHEIAGKITPFCRKIVHVNRKWRIIERVSIFGDFFRFLWRKIVSCSSIIEKPILYRRIVHKISSTAGDIFDGDDDTTTEPTVSGRRFGSSSDSDLVSLKISLLGDCQTGKTTFVVKYVGDENQSFLEMTGLNLMDKTFYVQGVTISFSIWDVGGDEKRSKDHIPIACKDAVAILFMFDLTSRSTLNSVFGWYSQARKWNKTAIPILIGTKFDDFVRLPPNLQWTIVTQARAYAKVMNASLFFSSATHNINVNKIFKFILARLFNLPWKIDRNLTLGEPIIDYDS