Protein: Genome polyprotein [Cleaved into: P1 protease (EC 3.4.21.-) (Leader protease P1) (N-terminal protein) (P1 proteinase); Helper component proteinase (HC-pro) (EC 3.4.22.45); Protein P3; 6 kDa protein 1 (6K1); Cytoplasmic inclusion protein (CI) (EC 3.6.4.-); 6 kDa protein 2 (6K2); Viral genome-linked protein (VPg); Nuclear inclusion protein A (NI-a) (NIa) (EC 3.4.22.44) (49 kDa proteinase) (49 kDa-Pro) (NIa-pro); Nuclear inclusion protein B (NI-b) (NIb) (EC 2.7.7.48) (RNA-directed RNA polymerase); Capsid protein (CP) (Coat protein)] (P04517)
Organism: Tobacco etch virus (TEV)
Function: Required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.
Subcellular location: [6 kDa protein 1]: Host cytoplasmic vesicle. Note=Probably colocalizes with 6K2-induced vesicles associated with host chloroplasts. {ECO:0000250|UniProtKB:P13529}.; SUBCELLULAR LOCATION: [6 kDa protein 2]: Host cytoplasmic vesicle {ECO:0000250|UniProtKB:P09814}. Note=6K-induced vesicles associate with host chloroplasts. {ECO:0000250|UniProtKB:P09814}.; SUBCELLULAR LOCATION: [Viral genome-linked protein]: Host nucleus {ECO:0000250|UniProtKB:P21231}. Note=Binds to host plant eIF4E proteins in the host nucleus. {ECO:0000250|UniProtKB:P21231}.; SUBCELLULAR LOCATION: [Capsid protein]: Virion {ECO:0000305}.
Interaction partners:
Sequence:
MALIFGTVNANILKEVFGGARMACVTSAHMAGANGSILKKAEETSRAIMHKPVIFGEDYITEADLPYTPLHLEVDAEMERMYYLGRRALTHGKRRKVSVNNKRNRRRKVAKTYVGRDSIVEKIVVPHTERKVDTTAAVEDICNEATTQLVHNSMPKRKKQKNFLPATSLSNVYAQTWSIVRKRHMQVEIISKKSVRARVKRFEGSVQLFASVRHMYGERKRVDLRIDNWQQETLLDLAKRFKNERVDQSKLTFGSSGLVLRQGSYGPAHWYRHGMFIVRGRSDGMLVDARAKVTFAVCHSMTHYSDKSISEAFFIPYSKKFLELRPDGISHECTRGVSVERCGEVAAILTQALSPCGKITCKRCMVETPDIVEGESGESVTNQGKLLAMLKEQYPDFPMAEKLLTRFLQQKSLVNTNLTACVSVKQLIGDRKQAPFTHVLAVSEILFKGNKLTGADLEEASTHMLEIARFLNNRTENMRIGHLGSFRNKISSKAHVNNALMCDNQLDQNGNFIWGLRGAHAKRFLKGFFTEIDPNEGYDKYVIRKHIRGSRKLAIGNLIMSTDFQTLRQQIQGETIERKEIGNHCISMRNGNYVYPCCCVTLEDGKAQYSDLKHPTKRHLVIGNSGDSKYLDLPVLNEEKMYIANEGYCYMNIFFALLVNVKEEDAKDFTKFIRDTIVPKLGAWPTMQDVATACYLLSILYPDVLRAELPRILVDHDNKTMHVLDSYGSRTTGYHMLKMNTTSQLIEFVHSGLESEMKTYNVGGMNRDVVTQGAIEMLIKSIYKPHLMKQLLEEEPYIIVLAIVSPSILIAMYNSGTFEQALQMWLPNTMRLANLAAILSALAQKLTLADLFVQQRNLINEYAQVILDNLIDGVRVNHSLSLAMEIVTIKLATQEMDMALREGGYAVTSEKVHEMLEKNYVKALKDAWDELTWLEKFSAIRHSRKLLKFGRKPLIMKNTVDCGGHIDLSVKSLFKFHLELLKGTISRAVNGGARKVRVAKNAMTKGVFLKIYSMLPDVYKFITVSSVLSLLLTFLFQIDCMIRAHREAKVAAQLQKESEWDNIINRTFQYSKLENPIGYRSTAEERLQSEHPEAFEYYKFCIGKEDLVEQAKQPEIAYFEKIIAFITLVLMAFDAERSDGVFKILNKFKGILSSTEREIIYTQSLDDYVTTFDDNMTINLELNMDELHKTSLPGVTFKQWWNNQISRGNVKPHYRTEGHFMEFTRDTAASVASEISHSPARDFLVRGAVGSGKSTGLPYHLSKRGRVLMLEPTRPLTDNMHKQLRSEPFNCFPTLRMRGKSTFGSSPITVMTSGFALHHFARNIAEVKTYDFVIIDECHVNDASAIAFRNLLFEHEFEGKVLKVSATPPGREVEFTTQFPVKLKIEEALSFQEFVSLQGTGANADVISCGDNILVYVASYNDVDSLGKLLVQKGYKVSKIDGRTMKSGGTEIITEGTSVKKHFIVATNIIENGVTIDIDVVVDFGTKVVPVLDVDNRAVQYNKTVVSYGERIQKLGRVGRHKEGVALRIGQTNKTLVEIPEMVATEAAFLCFMYNLPVTTQSVSTTLLENATLLQARTMAQFELSYFYTINFVRFDGSMHPVIHDKLKRFKLHTCETFLNKLAIPNKGLSSWLTSGEYKRLGYIAEDAGIRIPFVCKEIPDSLHEEIWHIVVAHKGDSGIGRLTSVQAAKVVYTLQTDVHSIARTLACINRRIADEQMKQSHFEAATGRAFSFTNYSIQSIFDTLKANYATKHTKENIAVLQQAKDQLLEFSNLAKDQDVTGIIQDFNHLETIYLQSDSEVAKHLKLKSHWNKSQITRDIIIALSVLIGGGWMLATYFKDKFNEPVYFQGKKNQKHKLKMREARGARGQYEVAAEPEALEHYFGSAYNNKGKRKGTTRGMGAKSRKFINMYGFDPTDFSYIRFVDPLTGHTIDESTNAPIDLVQHEFGKVRTRMLIDDEIEPQSLSTHTTIHAYLVNSGTKKVLKVDLTPHSSLRASEKSTAIMGFPERENELRQTGMAVPVAYDQLPPKNEDLTFEGESLFKGPRDYNPISSTICHLTNESDGHTTSLYGIGFGPFIITNKHLFRRNNGTLLVQSLHGVFKVKNTTTLQQHLIDGRDMIIIRMPKDFPPFPQKLKFREPQREERICLVTTNFQTKSMSSMVSDTSCTFPSSDGIFWKHWIQTKDGQCGSPLVSTRDGFIVGIHSASNFTNTNNYFTSVPKNFMELLTNQEAQQWVSGWRLNADSVLWGGHKVFMSKPEEPFQPVKEATQLMNELVYSQGEKRKWVVEALSGNLRPVAECPSQLVTKHVVKGKCPLFELYLQLNPEKEAYFKPMMGAYKPSRLNREAFLKDILKYASEIEIGNVDCDLLELAISMLVTKLKALGFPTVNYITDPEEIFSALNMKAAMGALYKGKKKEALSELTLDEQEAMLKASCLRLYTGKLGIWNGSLKAELRPIEKVENNKTRTFTAAPIDTLLAGKVCVDDFNNQFYDLNIKAPWTVGMTKFYQGWNELMEALPSGWVYCDADGSQFDSSLTPFLINAVLKVRLAFMEEWDIGEQMLRNLYTEIVYTPILTPDGTIIKKHKGNNSGQPSTVVDNTLMVIIAMLYTCEKCGINKEEIVYYVNGDDLLIAIHPDKAERLSRFKESFGELGLKYEFDCTTRDKTQLWFMSHRALERDGMYIPKLEEERIVSILEWDRSKEPSHRLEAICASMIEAWGYDKLVEEIRNFYAWVLEQAPYSQLAEEGKAPYLAETALKFLYTSQHGTNSEIEEYLKVLYDYDIPTTENLYFQSGTVDAGADAGKKKDQKDDKVAEQASKDRDVNAGTSGTFSVPRINAMATKLQYPRMRGEVVVNLNHLLGYKPQQIDLSNARATHEQFAAWHQAVMTAYGVNEEQMKILLNGFMVWCIENGTSPNLNGTWVMMDGEDQVSYPLKPMVENAQPTLRQIMTHFSDLAEAYIEMRNRERPYMPRYGLQRNITDMSLSRYAFDFYELTSKTPVRAREAHMQMKAAAVRNSGTRLFGLDGNVGTAEEDTERHTAHDVNRNMHTLLGVRQ