wanglab/gogpt-training-data huggingface dataset:
Protein: Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2) (Q71UI9)
Organism: Homo sapiens (Human)
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H4
- Histone H3.1
- Histone H2B type 2-E
- E1A-binding protein p400
- RuvB-like 1
- Helicase SRCAP
- Histone H2B type 1-O
- Histone acetyltransferase KAT5
- Histone H2A type 2-A
- Histone H3.3
Sequence:
MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTA
Protein: Uncharacterized MFS-type transporter YcaD (P21503)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Probable hydrolase YcaC
- Uncharacterized protein YhdV
Sequence:
MSTYTQPVMLLLSGLLLLTLAIAVLNTLVPLWLAQEHMSTWQVGVVSSSYFTGNLVGTLLTGYVIKRIGFNRSYYLASFIFAAGCAGLGLMIGFWSWLAWRFVAGVGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYVGTFLGQLLVSKVSTELMSVLPWVTGLTLAGILPLLFTRVLNQQAENHDSTSITSMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLNHKGVSNASIGFWMAVLVSAGILGQWPIGRLADKFGRLLVLRVQVFVVILGSIAMLSQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFTAMLMQNFSDNLLFIMIASVSFIYLLMLLRNAGHTPKPVAHV
Protein: Head-tail connector protein FII (Head-tail joining protein) (Minor capsid protein FII) (P03714)
Organism: Escherichia phage lambda (Bacteriophage lambda)
Function: Plays a role in virion assembly by joining the head and the tail at the last step of morphogenesis. Six FII proteins probably bind protein W that closes the DNA-filled capsid, as well as the U tail terminator protein of the pre-assembled tail.
Subcellular location: Virion {ECO:0000269|PubMed:5022189}. Host cytoplasm {ECO:0000269|PubMed:5022189}.
Interaction partners:
Sequence:
MADFDNLFDAAIARADETIRGYMGTSATITSGEQSGAVIRGVFDDPENISYAGQGVRVEGSSPSLFVRTDEVRQLRRGDTLTIGEENFWVDRVSPDDGGSCHLWLGRGVPPAVNRRR
Protein: LP01106p (Q8SZH0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPKGILTAKASAIGRKIQISLGIIRIGIEFVTGVGVQSTWYWVCESDREEERQCKCVGVAVTQAHTNILTTPVHKTPNCVRLSLFVSLALSPTFAHATPGERERERYRRAREPERESKEVVFPPKIWTKANCRVS
Protein: Muscleblind-like 2 (Drosophila), isoform CRA_a (cDNA FLJ76890, highly similar to Homo sapiens muscleblind-like 2 (Drosophila) (MBNL2), transcript variant 3, mRNA) (cDNA, FLJ79493, highly similar to Homo sapiens muscleblind-like 2 (Drosophila) (MBNL2), transcript variant 3, mRNA) (A2A3S3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHPVPTFPVGPAIGTNTAISFAPYLAPVTPGVGLVPTEILPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTSDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMAFPPGALHPLPKRQALEKSNGTSAVFNPSVLHYQQALTSAQLQQHAAFIPTDNSEIISRNGMECQESALRITKHCYCTYYPVSSSIELPQTAC
Protein: Small ribosomal subunit protein eS7B (40S ribosomal protein S7-B) (P48164)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eS7 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}. Nucleus, nucleolus {ECO:0000269|PubMed:15590835}.
Interaction partners:
- Small ribosomal subunit protein eS24A
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein eS10B
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein eS10A
- Small ribosomal subunit protein eS27A
- Small ribosomal subunit protein eS26B
Sequence:
MSSVQSKILSQAPSELELQVAKTFIDLESSSPELKADLRPLQIKSIREIDVTGGKKALVLFVPVPALSAYHKVQTKLTRELEKKFPDRHVIFLAERRILPKPSRTSRQVQKRPRSRTLTAVHDKVLEDMVFPTEIVGKRVRYLVGGNKIQKVLLDSKDVQQIDYKLESFQAVYNKLTGKQIVFEIPSQTN
Protein: AvrXccC (A5HIE4)
Organism: Xanthomonas campestris pv. campestris (strain 8004)
Interaction partners:
Sequence:
MGLCASKPSVAGSPARYTTHITETSPSESPSPSRRDSPSPSNNALREALPSPPLRTASSEPQGSPNWQGAGWPGHQGSSVWSEYQGNLHDSAHQWQGVSIGEYPDAPADMWSQPVWNPYASFDTGTASSHSQAVQGTATNYLRGPANYSKLSSEEQSLVGAARWPDDAPGLNISNKSNTQDNKKYCKSLYKASRIAGGSIASGQINSFNDLWQKATQWRLSRISSGDASKGDFAAERMPNTRFVTSLRRPYHSVIERARNHPDAETELYEGEYFKEIEVKVYRQCGAISGETIPMTTVSAAVDDNAISARLRNLPKDKRQQARQSMASSHPNMITHTSAEYIKTIRDHLESLYLQAIDPSLEKHEAFELIARLHWWAASAAPDKRGSAAKAEFAARSIASAHGIEMPPFRHGIVPDIEAMLRSESQFVADYPNFFERPPI
Protein: DNA mismatch repair protein (A0A1W2Q695)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSRQSTLYSFFPKSPALGDTKEAAARASRKGAAASGASASRGRDAAWSEAGPGSRPAALSTSLPEAKDLNGGLRRSAAPAVPASSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIRKNGKSARVHVQFFDDSPTRGWVSKRMLKPYTGSKSKEAQKGGHFYSSKSEILRAMQRADEALSKDKAQRLELAVCDEPSEPEEEEEEEEEETQVHGAYLSDKSEEENQDESEEETQPNAQGPRRSSRQVKKRRVISDSESDIGGSDVEFKPDSKQEGSSDEVSSGVGDSDSEGLGSFGKGAPKRKRTVAAHGGLKRKSLKKETGSAKQATRILSETKSTLSAFCAPQNSESQTHVCGGGNDSSGPTIWYHETLEWLKPEKRRDENRRRPDHPDYNSSTLYVPEDFLNSCTPGMRRWWQFKSQNFDLVIFYKVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPEIAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQTYSVLDGDPSENYSRYLLSLKEKEEDSSGHMRAYGVCFVDTSLGKFFLGQFSDDRHCSRLRTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGSQFWDATKTLRTLLEGGYFTGNEGSGAELPPVLKAMTSESDSVGLTPGEESELSLSALGGCVFYLKKCLIDQELLSMANFEEYFPLDSDMVGTVKPGAVFTKASQRMVLDAVTLSNLEIFLNGTNGSTEGTLLERLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAIEDLMAVPDKVAEVADLLKKLPDLERLLSKIHNVGSPLKSQNHPDTRAIMYEETTYSKKKIIDFLSALEGFKVMCKITRLMEDVADGFKSKTLKQVVTLQTKSPKGRFPDLTAELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLDKQRSRIGCRNIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTKKGCKRYWTKVIEKKLSNLINAEERRDASLKDCMRRLFYNFDKNHKDWQSAVECTAVLDVLLCLASYSQGGDGPMCRPVLLLPGEDTHPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEDAEADGKAYCVLVTGPNMGGKSTLIRQAGLLAVMAQMGCYVPAELCRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILRHATAHSLVLVDELGRGTATFDGTAIASAVVKELAETIKCRTLFSTHYHSLVEDYSKNVCVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFERMNQALQLFREVCLASERPTVNSEAIHRLLALVNQL
Protein: Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein) (Q63HQ2)
Organism: Homo sapiens (Human)
Function: Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q4VBE4}. Synaptic cleft {ECO:0000250|UniProtKB:Q4VBE4}. Presynaptic active zone {ECO:0000250|UniProtKB:Q4VBE4}. Note=Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals. {ECO:0000250|UniProtKB:Q4VBE4}.
Interaction partners:
- Dystroglycan 1
- Probable G-protein coupled receptor 179
- Dystrophin
Sequence:
MDLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKECGNYCLNTIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK
Protein: Probable carboxylesterase SOBER1-like (EC 3.1.1.-) (Q8GYK2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carboxylesterase.
Interaction partners:
- Probable carboxylesterase 1
- Probable carboxylesterase 12
- Carboxylesterase 20
- Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL1
- Ankyrin repeat 30A-like protein
- Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL2
- Photosystem I assembly factor PSA3, chloroplastic
Sequence:
MRTSRLKKPIVLLTIALLSSVFFFAFFFLNKSDVSSTSALRNRDSMARTFILWLHGLGDSGPANEPIKTLFRSQEFRNTKWLFPSAPPNPVSCNYGAVMPSWFDIPELPLTAGSPKDESSLLKAVKNVHAIIDKEIAGGINPENVYICGFSQGGALTLASVLLYPKTIGGGAVFSGWIPFNSSITNQFTEDAKKTPILWSHGIDDKTVLFEAGQAALPFLQQAGVTCEFKAYPGLGHSISNEELQYLESWLKQRMQSSSSSS
Protein: Uncharacterized protein (Q57ZG5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MANFNKVSRANAVLQPTAPATKYGNNGKNIRYHDVENLGEPFNNCRQRGYERNHIAPAPPVLGSEVNYFDNSASPMVSSDPGARHWGARNSYDSQWDNTYKSSGARAAATAVFEQIAAEERTSDGTQDMHGEVATENSTEYQSDGCAVVGHSRKILSSTEEYVCRRYSVSSIPRLEAYDYYETRKISPERAPHFSATAAHSDVRMRSPKPSVSSGGKSSDSMLQRRGEASTFPRVVARKLDLHATEECQGSSAHKQLSPMNAFEVANKAERQSQVGPTCPPVLTPCPSHNMRRSVADASTMTEGVSREAVTRAVHGNNLTTLPNGHYDNEYFNVGRGGPRSSANESVVSLSTVSNSTLNQRPDSTAFGGYRNPVGQHNHYVSPKLFHNSATQTMASSARPPLTPRFNETRSPPTAPPYAGWDNSPGGSMDRPALNGRPANDAMRVPRVGAAPQEVWAAKLRQLDNAYLTNGNGWAILHEIRLLLEGRNSR
Protein: NMDA receptor synaptonuclear signaling and neuronal migration factor (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor) (B8PYG1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Stimulates outgrowth of olfactory axons and migration of hypophysiotropic gonadotropin-releasing hormone 3 (GnRH3) neurons. May couple NMDA-sensitive glutamate receptor signaling to the nucleus and trigger long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes.
Subcellular location: Nucleus {ECO:0000250}. Nucleus envelope {ECO:0000250}. Nucleus membrane {ECO:0000250}. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Synapse {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Postsynaptic density {ECO:0000250}. Membrane {ECO:0000250}.
Interaction partners:
- Prokineticin
- Prokineticin receptor 1b
- Anosmin 1a.
- Heparan-sulfate 6-O-sulfotransferase 1-A
- Fibroblast growth factor receptor 1-A
- DNA helicase
- Type II GnRH receptor
Sequence:
MGTVVSKKENLRNDAISSVAAKVRAARAFGEYLSHTRPENRNRSDHLLSDTFIGQETDSPDISRLNNNNSLQPYSQHTLIVKPSQEELQQGSQSAPLPTSSKRRLSVERSLSSEDQQNQRRTESSVKPARVYTITRERDMLGGQGSEESLELEVLKRTSEPSQINPPTGLRGSHHRGSQHRGNNGPTHQHHYGHAPMAQPLQSSGSTHNIRDWGSRRSRSREDCTPDCVACIRPHCQSQRSLDLDTSPHGGGKQHKKLERMYSEDRVSSEDREDHTNSWFPKENMFSFQTATTTMQAISNFRKHLRMVGSRRVKAQTFVDRKAKSFSRSWSDPTPVKPDSLHDSRDSGDLQASSGNLDEEDCDDVDWEEERELERVACEGDDFIPPKLMLISSKVPKAEYVPNIIRRDDPSIIPILYDHEHATFDDILEEIEKKLTAYRKGCKIWNMLIFCQGGPGHLYLLKNKVATFAKVEKEEGMMQFWKKLGRFMSLLNPEPNLIHIMGCYVLGNANGEKLFQNLKRLMKPHGIEFKSPLELSAQGKEMIEMYFDFRLYRLWKTRQHSKLHDYDDLL
Protein: Dihydrolipoyllysine-residue acyltransferase component of branched-chain alpha-ketoacid dehydrogenase complex (EC 2.3.1.168) (Branched-chain alpha-ketoacid dehydrogenase complex component E2) (BCKADH E2) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (O06159)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2).
Interaction partners:
- 3-methyl-2-oxobutanoate dehydrogenase subunit beta
- 3-methyl-2-oxobutanoate dehydrogenase subunit alpha
- Dihydrolipoyl dehydrogenase
- Pyruvate dehydrogenase E1 component
- Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase alpha1 subunit
- Probable dehydrogenase
- Multifunctional 2-oxoglutarate metabolism enzyme
- Citrate synthase 1
- Putative citrate synthase 2
- 2-methylcitrate synthase
Sequence:
MSGEDSIRSFPVPDLGEGLQEVTVTCWSVAVGDDVEINQTLCSVETAKAEVEIPSPYAGRIVELGGAEGDVLKVGAELVRIDTGPTAVAQPNGEGAVPTLVGYGADTAIETSRRTSRPLAAPVVRKLAKELAVDLAALQRGSGAGGVITRADVLAAARGGVGAGPDVRPVHGVHARMAEKMTLSHKEIPTAKASVEVICAELLRLRDRFVSAAPEITPFALTLRLLVIALKHNVILNSTWVDSGEGPQVHVHRGVHLGFGAATERGLLVPVVTDAQDKNTRELASRVAELITGAREGTLTPAELRGSTFTVSNFGALGVDDGVPVINHPEAAILGLGAIKPRPVVVGGEVVARPTMTLTCVFDHRVVDGAQVAQFMCELRDLIESPETALLDL
Protein: 5'-nucleotidase (EC 3.1.3.5) (Q7K0L5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Apyrase
- Adenine phosphoribosyltransferase
- Adenosine kinase
- Adenosine kinase
- Adenosine kinase
- Uncharacterized protein, isoform C
- Adenylosuccinate lyase
- Adenylosuccinate synthetase
- apyrase
- Bifunctional purine biosynthesis protein ATIC
Sequence:
MLPARGLLIGSCCLLALLIHPVQPNPIAPRAEVAAEFIILHNNDMHARFEQTSVTSGTCSKEEANTDQCYGGFARVAYEVRKYRKEAEEGGTPVFYLNAGDTYTGTAWFTVYKDKIASAFLNKLSPDAISLGNHEFDQNVEGLVPFLNAVEFPVLACNLNLTDVPEMAAAKQLANSTILERNGVKVGVIGYLTPDTKVLAFRNKVEYEEEIVSINAEAAKLKAQGINIIIALGHSGYQKDQEIAMNCPEVDIVIGGHSHTFLDANQPVADPTDSDPEAVRGPYPTTVVQASGKKVPVVQAYAYTKYLGKIHVQFDAEGNLIEFDGAPILLNASVAQEQDLLDLLDEYRPKLDELENTVLGYTKVFLEGGNICRMRECNLGNLVTDAMIYSRVLENKGGEFWTDTAIAFMQGGGIRGSVDKKDDGVINGATLLAVLPFENNLYVTRILGSTLLAALEHSASVRLQDSNGGFLQMSGLRVVYNYNNEQGKRVVSAQALCASCAVPTYKSINETALYQVIVPQFLLEGGDGYTLIEESDPFTESMQRNDLNATMEYLKQRHFVYPEIEERIVIHEKADTGSASGIVASISLLLLSSLLTRFI
Protein: Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] (P97821)
Organism: Mus musculus (Mouse)
Function: Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.
Subcellular location: Lysosome {ECO:0000250|UniProtKB:P53634}.
Interaction partners:
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- BH3-interacting domain death agonist
- Protein ERGIC-53
- Legumain
- H-2 class II histocompatibility antigen gamma chain
- Cathepsin G
- Cathepsin D
Sequence:
MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL
Protein: Aldehyde dehydrogenase (Q99PH4)
Organism: Mus musculus (Mouse)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004131}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004131}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004131}. Microsome membrane {ECO:0000256|ARBA:ARBA00004524}.
Interaction partners:
Sequence:
MERQVLRLRQAFRSGRSRPLRFRLQQLEALRRMVQEREKEILAAIAADLSKSELNAYSHEVITILGEIDFMLGNLPELASARPAKKNLLTMMDEAYVQPEPLGVVLIIGAWNYPFVLTMQPLVGAIAAGNAAIVKPSELSENTAKILAELLPQYLDQDLYAIVNGGIPETTELLKQRFDHILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDRDCDLDVACRRVAWGKYMNCGQTCIAPDYILCEASLQNQIVQKIKETVKDFYGENIKASPDYERIINLRHFKRLQSLLKGQKIAFGGEMDEATRYLAPTILTDVDPNSKVMQEEIFGPILPIVSVKNVDEAINFINDREKPLALYVFSRNNKLIKRVIDETSSGGVTGNDVIMHFTVNSLPFGGVGASGMGAYHGKYSFDAFSHQRPCLLKGLKGESVNKLRYPPNSESKVSWAKFFLLKQFNKGRLGMLLFVCLVAVAAVIVKKYQALPRGKALLASLIVHRRRWSSKH
Protein: Cyclin E2 (D3ZQ41)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinase inhibitor 1
- M-phase inducer phosphatase 1
- Cyclin-dependent kinase inhibitor 1C
- Cyclin-dependent kinase 4
- cyclin-dependent kinase
- Retinoblastoma-associated protein
- Retinoblastoma-like protein 2
- Retinoblastoma-like protein 1
Sequence:
MSRRSSRLQAKQQHARPNQPDSPQEAQIIQAKKRKTAQDVKKRTEEITKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWACSQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWELCPVTVISWLNLFLQVDAVKDIPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWDDISECVDWMVPFVSVVKSVSPVKLKTFKKIPMEDRHNIQTHTNYLALLNEVNYVNIFRKGGQLSPVCNGGIMTPPKSTEKPPVKF
Protein: ATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33) (Q80VY9)
Organism: Mus musculus (Mouse)
Function: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation. Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (By similarity). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (By similarity). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:21930779}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9H6R0}. Cytoplasm {ECO:0000250|UniProtKB:Q9H6R0}. Nucleus {ECO:0000250|UniProtKB:Q9H6R0}. Inflammasome {ECO:0000250|UniProtKB:Q9H6R0}. Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions. Upon dsRNA-binding, localizes in the inflammasome. {ECO:0000250|UniProtKB:Q9H6R0}.
Interaction partners:
- Mitochondrial antiviral-signaling protein
- 2-5A-dependent ribonuclease
- ATP-dependent RNA helicase DDX3X
- NACHT, LRR and PYD domains-containing protein 9B
- Caspase-1
- NACHT, LRR and PYD domains-containing protein 6
- Interferon-inducible protein AIM2
- Pyrin
- WD repeat domain 36
- Gasdermin-D
Sequence:
MPEEASLPPAKRFRPGSCPPGRRVVMLLTAGGGGGAGGGRRQTPPLAQPSASPYREALELQRRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNRAPVLYLEGRQHPIQIFYTKQPQQDYLHAALVSVFQIHQEAPASQDILVFLTGQEEIEAMSKTCRDIARHLPDGCPSMLVLPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGALEHKDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDHITLLNIYRTFKNIGGNKDWCKENFVNSKNMLLVAEVRAQLREICLKMSMPIMSSRGDMESVRRCMAHSLFMNTAELQTDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAPDYFRRKLRTARN
Protein: Transcription factor Ken (Protein Ken and Barbie) (O77459)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MKEFQRMLMLQYSKHGECILKEIGAAFRGEHPADLTIVCENKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYLHDLLLLLQIKSDSWKTTDSAYLSSKCGGLRDRADRRKQQYTSPQNLEPDQTLKYEVDSVDESRNAADFSSAFNSNDNCESAAECERSGGHNNKEEDEDDCTHKDNKSDKDTDEIVNLSNAPPSGTSGSNSNISTSSNHQQQQHHHHHHHNHNNNNNNNNNNSSSSTINPVNLSLDLRTKSENSASRTLGSGSDHSGIDLAVTASESTKRKGLFFDSHKDVMKPLSDGSDINSSPENYVVTPHRKRRPGFHNTQSDNQPFTSYPHSLLEELRLAKSTTSPISGFGSEKNMLAHLEDGALNGDTLTPDRKHLLEAQRNRAQSPEIPMHLGPQFVYQWQSNQNAAMSAMPNLQSRLSSLSHISLNLDHPEGRSGSASGSGANLAGSNTHASSVREYRCEYCGKQFGMSWNLKTHLRVHTGEKPFACRLCVAMFKQKAHLLKHLCSVHRNVITTTNGADTENRYSCCFCSMCFESVQELVRHLSGHHNNLLLTKNLRE
Protein: Expression site-associated gene (ESAG) protein, putative (Q38BG3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFFFFVVVVPYCGGGMFVTYLIFSSNESRLYGYCLFMPFCFVVKSFSVFFFSFHFSEKGWFMLKGPWVGGDARKRLYVMAAVMLLIVLMFMGVMDFRKREAKRWVKNSSLNDHSPGVYYVVVQTKPSPGWCRMLLSSVLTNVRVATVGAGAVYVHAWRWAWIRKYMLWKRMQDNDVMVIFDGGDTFFSEAARREEAIEYFMNTTPSTRELFSEEDTLHGKMAPPLLFAAEKNCHAPQTYIMTGVDTRKVKPRDMCMNLYEGALAVSIKEGTQALLRETPSGESHLNGGGMIARVWALKEALEVFFALKRRSFKWWCDQSMWTMVFIWSVTRPKHANRKLLLRRGIMSLDYETRYFHYPSGVPVKNGMILHFPGPPAARSEKMLQFINETSWYRALRDSSTQREAYKYLLERYTTEIHTVWGSRKYVKFSTVCNVSNAANPRWLIGPLNKK
Protein: U1 snRNP-associated protein usp106 (Protein luc7) (Q9USM4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-processing factor 39
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- U1 small nuclear ribonucleoprotein C
- U1 snRNP-associated protein usp107
- Small nuclear ribonucleoprotein Sm D1
- Pre-mRNA-splicing factor dre4
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-processing protein prp40
- Small nuclear ribonucleoprotein-associated protein B
- Small nuclear ribonucleoprotein Sm D2
Sequence:
MAAEQRKIIEQLMGSNLSNFTSRGLVHFTDRKVCRSFLCGICPHDIFTNTKMDLGPCPKIHSDKLKSDYERASYSHDYGYEWDYLEDLERHVDDCNKRIDIAEARREKTKEEEERIDELMRDIIHTDHSIEVIITEMEALAKRKLVNDAVKHFIELNRLKTYRKELYDEVISMNEIPSQASTTHQKLQVCDICSAYLSRLDNDRRLADHFSGKMHLGYAMLRNIARDLRAQLEDREKSRDKKDGEKQRDNLASFEDKISTSFVA