wanglab/gogpt-training-data huggingface dataset:
Protein: 26S proteasome regulatory subunit 8 homolog (Protein CIM3) (Protein SUG1) (Tat-binding protein TBY1) (Q01939)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- 26S proteasome regulatory subunit RPN3
- Proteasome subunit beta type-4
- 26S proteasome regulatory subunit RPN1
- 26S proteasome regulatory subunit RPN14
- 26S proteasome regulatory subunit RPN10
- Ubiquitin carboxyl-terminal hydrolase RPN11
- 26S proteasome regulatory subunit RPN6
- Proteasome subunit beta type-2
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-2
Sequence:
MTAAVTSSNIVLETHESGIKPYFEQKIQETELKIRSKTENVRRLEAQRNALNDKVRFIKDELRLLQEPGSYVGEVIKIVSDKKVLVKVQPEGKYIVDVAKDINVKDLKASQRVCLRSDSYMLHKVLENKADPLVSLMMVEKVPDSTYDMVGGLTKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARAVAHHTDCKFIRVSGAELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSTRVEGSGGGDSEVQRTMLELLNQLDGFETSKNIKIIMATNRLDILDPALLRPGRIDRKIEFPPPSVAARAEILRIHSRKMNLTRGINLRKVAEKMNGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVGKVMNKNQETAISVAKLFK
Protein: Sorbitol dehydrogenase (SDH) (SORD) (EC 1.1.1.-) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9) (Q64442)
Organism: Mus musculus (Mouse)
Function: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation. Has no activity on ethanol. Cannot use NADP(+) as the electron acceptor.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:18799757}; Peripheral membrane protein {ECO:0000269|PubMed:18799757}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:18799757}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.
Interaction partners:
- Aldo-keto reductase family 1 member B1
- Hexokinase HKDC1
- Hexokinase-3
- Hexokinase-1
- Aldose reductase-related protein 2
- Hexokinase-2
- Aldo-keto reductase family 1 member B7
- aldose reductase
- L-xylulose reductase
- Xylulose kinase
Sequence:
MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGELVKHLKPGDRVAIEPGVPREVDEYCKIGRYNLTPTIFFCATPPDDGNLCRFYKHNADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPVGMVTLLVAKAMGAAQVVVTDLSASRLTKAKEVGADFTIQVGKETPQEIASKVESLLGSKPEVTIECTGAESSVQTGIYATHSGGTLVIVGMGAEMVNLPLVHAAIREVDIKGVFRYCNTWPMAISMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGVGLKVMIKCDPNDQNP
Protein: Formin-homology and zinc finger domains protein 1 (P34489)
Organism: Caenorhabditis elegans
Function: Acts redundantly with hlh-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2.
Interaction partners:
- FH2 domain-containing protein
- FH2 domain-containing protein
- Cell division control protein 42 homolog
- WAPL domain-containing protein
- Excretory canal abnormal protein 6
- Formin HOmology Domain
- Ras-related protein ced-10
- C2H2-type domain-containing protein
- LIM/homeobox protein lim-6
Sequence:
MMLASSAPTAPSLLPPSSQPSAATTRADDCSSSTSPTNTSASDASMEMLTSLMNGAVAAAAAPGNALVKQESPPLTTPPLFNPDLALLQFSQLFQAQQAMVQFHNQQKQQQQIIQQQQQQQQQQQQNQNPSQSQSSSSDRKRSYPCTFQYCVICQKDVHSSKLPCHIRQCHVAKPMFQCPACDFTSTYSKNNVKSHMVSLHGLAGDPISYMDKYAGQVEEFMKLCFPNVRGRGRPMQGRSSPKSPTSPTQPGRRGSQASSLPSRRNTVSQNDLLATLQQHQQQQAAFHPLRNLRFNPLQSIFPAVLANNNNNSVLATNKHVNNFLIKQEESEVPPITMPMQDLKTMLDANSSPSPISLSSSIIPIQPIKPGENAQPKYMKSLDWTILNDLQMKGTVFADCRSNMELYAENIARKIENTKAFQSFVLSDDMRTVVEEVRSRVSIQLFEVMFAIHRMDIKVLNQNLVDSLLQIAPTNSDAQLLRKMENLSDPNEEFLLGLTKIDHIEEKLETMKHMYRFPEQVELLKENIIKYEIAVKVLSESRALRNVMQLVLAILNIGFFDDRQCLSINGFSVSDISSILSTNTPSGQSVQSILVTILKDEINLDLDELFGLIDVLEKIENDDVNSVAQDLMVLDDKTVRAEKEMEHSGSNIPLSEFVENAKTISKERWEHFKSLKTSIERLTIYLGSPLPRHQNLDAHSPFNNVLQMLRSLKTAIELDDASDDHHINVSSP
Protein: Aquaporin 1 (Aquaporin PIP1-3-like) (Q06Z30)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEGKEEDVKLGANKFSERQPIGTSAQTDKDYKEPPPAPLFEPGELKSWSFYRAGIAEFVATFLFLYITVLTVMGVSQSKTKCTTVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLLLARKLSLTRAVFYMIMQCLGAICGAGVVKGFEGDSRYEMLGGGANVVNHGYTKGDGLGAEIIGTFVLVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKDHAWDDHWIFWVGPFIGAALAAIYHQIIIRAIPFKTRA
Protein: Nucleoprotein (Nucleocapsid protein) (NP) (Protein N) (Q9DQA5)
Organism: Mumps orthorubulavirus (MuV)
Subcellular location: Virion {ECO:0000250|UniProtKB:Q77IS8}. Host cytoplasm {ECO:0000250|UniProtKB:D5LWW7}. Note=Found in cytoplasmic viral factories. {ECO:0000250|UniProtKB:D5LWW7}.
Interaction partners:
Sequence:
MSSVLKAFERFTIEQELQDRGEEGSIPPETLKSAVKVFVINTPNPTTRYQMLNFCLRIICSQNARASHRVGALITLFSLPSAGMQNHIRLADRSPEAQIERCEIDGFEPGTYRLIPNARANLTANEIAAYALLADDLPPTINNGTPYVHADVEGQPCDEIEQFLDRCYSVLIQAWVMVCKCMTAYDQPAGSADRRFAKYQQQGRLEARYMLQPEAQRLIQTAIRKSLVVRQYLTFELQLARRQGLLSNRYYAMVGDIGKYIENSGLTAFFLTLKYALGTKWSPLSLAAFTGELTKLRSLMMLYRDLGEQARYLALLEAPQIMDFAPGGYPLIFSYAMGVGTVLDVQMRNYTYARPFLNGYYFQIGVETARRQQGTVDNRVADDLGLTPEQRTEVTQLVDRLARGRGAGIPGGPVNPFVPPVQQQQPAAVYEDIPALEESDDDGDEDGGAGFQNGAQAPAVRQGGQNDFRAQPLQDPIQAQLFMPLYPQVSNIPNHQNHQINRIGGMEHQDLLRYNENGDSQQDARGEHGNTFPNNPNQNAQSQVGDWDE
Protein: Protein COS2 (P0CX12)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Protein COS4
Sequence:
MKENELKNEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIYKSLAFRIWMLLWLPLSVWWKLSNNCIYPLIVSLLVLFLGPIFVLVICGLSRKRSLSKQLIQFCKEITENTPSSDPHDWEVVAANLNSYLYENNVWNTKYFFFNAMVCQEAFRTTLLEPFSLKKDKAAKVKSFKDSVPYIEEALGVYFTEVEKQWKLFNTEKSWSPVGLEDAKLPKEAYRFKLTWFLKRISNIFMLIPFLNFLCCIYVSRGMCLLLRTLYLGWILFMLVQGFQNIRVLIMSMEHKMQFLSTIINEQESGANGWDEIARKMNRYLFEKKAWKNEEFFFDGIDCEWFFNHFFYRVLSAKKSMWPLPLNVELWPYIKEAQLSRSEVLLV
Protein: Oxygen-evolving enhancer protein 1-1, chloroplastic (OEE1) (33 kDa subunit of oxygen evolving system of photosystem II) (33 kDa thylakoid membrane protein) (Manganese-stabilizing protein 1) (MSP-1) (OEC 33 kDa subunit) (P23321)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stabilizes the manganese cluster which is the primary site of water splitting.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:11719511, ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:2583096}; Peripheral membrane protein {ECO:0000269|PubMed:11719511, ECO:0000269|PubMed:2583096}; Lumenal side {ECO:0000269|PubMed:11719511, ECO:0000269|PubMed:2583096}. Note=Associated with the photosystem II complex.
Interaction partners:
- Chlorophyll a-b binding protein CP26, chloroplastic
- Photosystem II CP43 reaction center protein
- Photosystem II CP47 reaction center protein
- Cytochrome b559 subunit beta
- Photosystem II D2 protein
- Oxygen-evolving enhancer protein 3-1, chloroplastic
- Cytochrome b559 subunit alpha
- Photosystem II protein D1
- Oxygen-evolving enhancer protein 3-2, chloroplastic
- Photosystem II reaction center protein H
Sequence:
MAASLQSTATFLQSAKIATAPSRGSSHLRSTQAVGKSFGLETSSARLTCSFQSDFKDFTGKCSDAVKIAGFALATSALVVSGASAEGAPKRLTYDEIQSKTYMEVKGTGTANQCPTIDGGSETFSFKPGKYAGKKFCFEPTSFTVKADSVSKNAPPEFQNTKLMTRLTYTLDEIEGPFEVASDGSVNFKEEDGIDYAAVTVQLPGGERVPFLFTVKQLDASGKPDSFTGKFLVPSYRGSSFLDPKGRGGSTGYDNAVALPAGGRGDEEELVKENVKNTAASVGEITLKVTKSKPETGEVIGVFESLQPSDTDLGAKVPKDVKIQGVWYGQLE
Protein: Large ribosomal subunit protein uL23z (60S ribosomal protein L23a-1) (AtRPL23A-1) (Q8LD46)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to a specific region on the 26S rRNA.
Interaction partners:
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL6z/uL6y
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein eL39z/eL39x
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein uL5z
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein uL1y
Sequence:
MSPAKVDTTKKADPKAKALKAAKAVKSGQAFKKKDKKIRTKVTFHRPKTLTKPRTGKYPKISATPRNKLDHYQILKYPLTTESAMKKIEDNNTLVFIVDIRADKKKIKDAVKKMYDIQTKKVNTLIRPDGTKKAYVRLTPDYDALDVANKIGII
Protein: Protein kinase 2 (EC 2.7.1.-) (Q8I534)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MEKRYQQLFKGKRIDFPLATGAASHVSLTYDEKKNPYLLCWTYIYQEKPEFTVPLKGCRIINNITEIGPCIHIITSNEEYQFQCRSKEEFDEMSQFFNMLGYPILGFKNVYVLNKKIGKGSFSTAYIGTNILYGNRVVVKEVDKSKVKESNVYTEIEVLRKVMHKYIIKLISAYEQEGFVYLVLEYLKGGELFEYLNNNGPYTEQVAKKAMKRVLIALEALHSNGVVHRDLKMENLMLENPNDPSSLKIIDFGLASFLNSPSMNMRCGSPGYVAPEILKCASYGTKVDIFSLGVILFNILCGYPPFRGNNVKEIFKKNMRCHISFNTKHWINKSESVKEIILWMCCKNPDDRCTALQALGHQWFLPKLTDMHMTANINELKRNEAIVHKSNDQQDMCKKCKHFNNTQNDDIYNNNNNNQLDPNKNHKNNYNDYKNYFHTMLKIDDKYSENLIKDKTSMDSISLNKKDYDAYLVHSNEHDTVVLHGKCETTKNSSSLLSYKCSRRSPPQN
Protein: Rho GDP dissociation inhibitor (GDI) gamma (Rho GDP dissociation inhibitor gamma) (A2ID99)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLGLDACELGAQLLELLRLALCARVLLADKEGGPPAVDEVLDEAVPEYRAPGRKSLLEIRQLDPDDRSLAKYKRVLLGPLPPAVDPSLPNVQVTRLTLLSEQAPGPVVMDLTGDLAVLKDQVFVLKEGVDYRVHREIVSGLKCLHHTYRRGLRVDKTVYMVGSYGPSAQEYEFVTPVE
Protein: Myosin regulatory light chain 12B (Myosin RLC-B) (Myosin regulatory light chain 2-B, smooth muscle isoform) (MLC-2) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (P18666)
Organism: Rattus norvegicus (Rat)
Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
Interaction partners:
- Myosin light polypeptide 6
- Myosin-9
- Rho-associated protein kinase 2
- Myosin-10
- Rho-associated protein kinase 1
- Myosin-10
- Myosin light chain kinase 2, skeletal/cardiac muscle
- Actin, cytoplasmic 1
- Myosin light chain kinase 3
- Actin, cytoplasmic 2
Sequence:
MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDAYLDAMMNEAPGRINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
Protein: G protein-coupled receptor 49 (Leucine-rich repeat-containing G protein-coupled receptor 5, isoform CRA_b) (A0A0A8K8C7)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSSVAFVPCL
Protein: LP11612p (Q9VUG2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMMLHLRHWPLVLAMASCLLFTAATSATPATPATPATSAPPATSTATSSLSSIPGKYQALGAAHHQAKKLKIGDVNASSSDANKPVFRQNPIKNWFGAFNRNNSPAAQNQTSPTCSCRCGERNDESRIVGGTTTGVSEYPWMARLSYFNRFYCGGTLINDRYVLTAAHCVKGFMWFMIKVTFGEHDRCNDKERPETRFVLRAFSQKFSFSNFDNDIALLRLNDRVPITSFIRPICLPRVEQRQDLFVGTKAIATGWGTLKEDGKPSCLLQEVEVPVLDNDECVAQTNYTQKMITKNMMCSGYPGVGGRDSCQGDSGGPLVRLRPDDKRFEQIGIVSWGNGCARPNYPGVYTRVTKYLDWIVENSRDGCFCDEDY
Protein: Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) (P62717)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}.
Interaction partners:
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein eS12
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL33
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL43
Sequence:
MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAAGKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF
Protein: V-type proton ATPase subunit c5 (V-ATPase subunit c5) (V-type proton ATPase 16 kDa proteolipid subunit c5) (V-ATPase 16 kDa proteolipid subunit c5) (Vacuolar H(+)-ATPase subunit c isoform 5) (Vacuolar proton pump 16 kDa proteolipid subunit c5) (Vacuolar proton pump subunit c5) (P0DH94)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subcellular location: Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Interaction partners:
- V-type proton ATPase subunit D
- V-type proton ATPase subunit F
- V-type proton ATPase subunit B1
- V-type proton ATPase subunit C
- V-type proton ATPase subunit H
- V-type proton ATPase subunit G1
- V-type proton ATPase catalytic subunit A
- ATP synthase subunit b, chloroplastic
- V-type proton ATPase subunit d1
- V-type proton ATPase subunit d2
Sequence:
MSTFSGDETAPFFGFLGAAAALVFSCMGAAYGTAKSGVGVASMGVMRPELVMKSIVPVVMAGVLGIYGLIIAVIISTGINPKAKSYYLFDGYAHLSSGLACGLAGLSAGMAIGIVGDAGVRANAQQPKLFVGMILILIFAEALALYGLIVGIILSSRAGQSRAE
Protein: Leptin (Obesity factor) (Q4LAM1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MVIRIKKLDISPNLIEGMDPFLPAAAVDQHIESLPSIVETMGFYQDLLLVLDWADLKQLVEDTSTMRGLLENWMTSRCPARQQKQTGEGGLSEALKDTTRKYGLSVGPVALNRLKGYLGRLLLN
Protein: Plexin C1 (Q5RGW1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Plexin D1.
- Ras-related protein Rap-1b
- Semaphorin 7A
- Ras-related protein Rap-1b
- Plexin b2a.
- Si:dkey-183c2.4
- Uncharacterized protein
- Si:ch211-127b11.1
- Semaphorin-4E
- Sema domain, immunoglobulin domain
Sequence:
SDLQPLSVVFKSSSMSSVAAVRNGSWIVLFMGNSDGQLIKLVLDENYTPSCPTVLYKSDDERAVFPRMHFDPVDSKYIYIALRKQIRRVSVVRCAKYNTLKDCRSALDPLCGWCVNTQRCVQCISSGCHWSSSSKRCGWTQGREPQLNIQDACKDLLSEYKEPEILSLEPHKVSFNGRNNVLLRGRNLDSVTKIRIQGDLGCIAKESPVFDPSSDTLVFNIPPSESKGTVKMCVVTPDNRCHGNSIITYSSQPRCTGVQPRNSWRSGGRKIHVQGTNMEYVESVIVQPSNIFLKSQYDASSRDMWFYSHRIEGSDHFTLSLMVGNSTEACDHDFSYEPDPVFTGFTTLQVANDLQVNIQKKADKLNLNISEVKVAGLHGDKGYQCVVERIESNAVICKIKAGPGALDSLNISIGHFYVKQTFESPSGMKYFSILVVLIVIIILGAVVGVIVHRKSQKQMSKKMNDQLELMESNIRRDIRQGFVDLQTEKSDLIDNVGAIPFLDYKHFASRIFFPEAGTLTAVMIRDIGEDSEQTTVDEKCLAFAELIRDKQFLSCFVHALEEQKNFSIKDKCTVASLLTLALHGDLLYLTEIMEDLLQSLMDQSSNANPKLLLRRTESIVEKLLTNWMSICLYGFLRESVGQPLFLLVSALTQQISKGPVDSVTEKALYTLSEDWLLCQAQDFEPLKLKVVFAVGTGEEISESLEVIALTCDTIQQVKEKILQTFQRKFGFRYTQQIRDIEIEYEKEGKFVMLQEVDDTSEIRGHVTMLNTLKHYQVGDGACIKVITPKIHAPLKTQNSVKDDKNFSIKYFHLVDPDIDTDLSNHPEKKALKIKEMYLIKLLSTKVAVHSFVENLFKSIWGLPNNKAPLAVKYFFDFLDEQAERKKITDPDVLHIWKTNSLPLRFWVNILKNPDFVFSDMEKSPHLDGCLSVIAQAFMDSFSLTDTHLDKHSPTNKLLYGKDIPQYKQEVKSYYKLVKDQTSISSQELKTFLQEESKKHQNEFNESAALRELYKYMQRYFTEIFQKLEQTDAPSNLKENMHRVKELFDNMKRSGWN
Protein: Hydroxyproline-rich glycoprotein family protein (F4HWB0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mucin-like protein
- F-box/kelch-repeat protein At1g55270
- F21J9.27
- At2g29210/F16P2.41
- Flavonol 3-O-glucosyltransferase UGT71C4
- UDP-glycosyltransferase 71C2
- RNA-binding motif protein 25
- UDP-glycosyltransferase 71B7
- UDP-glycosyltransferase 85A3
- UDP-glycosyltransferase 71C3
Sequence:
MAMPPPGNVTTPSEKLQFPPPANWIPDERDGFISWLRAEFAAANAIIDSLCQHLQAVGDHNEYESVIGSIHHRRLAWSQVLTMQQFFPVADVSYNLQQIAWKRQQQMPPQRHYNSDQVGKFGARRSGPGFNKHHGGGGGYRGADSMARNGHNFNGVNSDRVEHREEAKLASDVKALSVAEEKRDGSEKPRSDSKVEKKLEESETQEEIVKNHKCNSGSKDNSLISEQKQEENDKECPASMAKTFVVQEMYDAKMVNVVEGLKLYDKMLDANEVSQLVSLVTNLRLAGRRGQLQSEAYVGYKRPNRGHGREMIQLGLPIADTPPDDDSIKDRRIEPIPSALSDIIERLVSKQIIPVKPDACIIDFFSEGDHSQPHMFVPWFGRPISVLSLSECDYTFGRVIVSENPGDYKGSLKLSLTPGSVLLVEGKSANLAKYAIHATRKQRILISFIKSKPRNSNWGPPPSRSPNQHIRHPTGPPKHYPVVIPSTGVLPTPSHRPPNGAVQPIFIPPSPPLASPMPFPGGVPTGPPVWPLLPPHPRHQTAPQPRMPIPGTGVFLPPGSNQELADNSNGTEGKLDLKAKEEARNGFGEGECDGSNGKQSN
Protein: U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) (Q8JGS0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03153}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein polypeptide A'
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein E
- Nuclear cap-binding protein subunit 2
- Small nuclear ribonucleoprotein polypeptide F.
- Small nuclear ribonucleoprotein Sm D3
- Splicing factor 3B subunit 4
- U1 small nuclear ribonucleoprotein A
Sequence:
MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFPGAPPPGGSLLPHPSIGGPPRPGMLPAPPMGGPPMMPMMGPPPHAMMPGGPGPGMRPPMGGPMQMMPGPHMMRPPARPMMPAVRPGMVRPDR
Protein: Kinetochore null protein 2 (O44548)
Organism: Caenorhabditis elegans
Function: Required for the recruitment of hcp-3, hcp-4, knl-1, bub-1 and lin-53 to kinetochores, kinetochore assembly, chromosome condensation and chromosome segregation in meiosis and mitosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:17339379}. Chromosome, centromere {ECO:0000269|PubMed:17339379}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17339379}. Note=Requires hcp-3 for chromatin localization. {ECO:0000269|PubMed:17339379}.
Interaction partners:
- Histone H3-like centromeric protein hcp-3
- Kinetochore protein ndc-80
- Outer kinetochore KNL1 complex subunit knl-1
- Mitotic checkpoint serine/threonine-protein kinase bub-1
- HoloCentric chromosome binding Protein
- Kinesin-like protein
- CENP-C-like protein HCP-4
Sequence:
MGDTEIVPLRVQNVLDSEIIRLNLWSMKFNATSFKLEGFVRNEEGTMMQKVCSEFICRRFTSTLLFDVSGRFFDLVGQIDREYQQKMGMPSRIIDEFSNGIPENWADLIYSCMSANQRSALRPIQQAPKEPIRTRTEPIVTLADETELTGGCQKNSENEKERNRREREEQQTKERERRLEEEKQRRDAEAEAERRRKEEEELEEANYTLRAPKSQNGEPITPIRFTRGHDNGGAKKVFIFEQTPVRKQGPIASSTPQQKQRLADGANNQIPPTQKSQDSVQAVQPPPPRPAARNAQFASDADLFAVPKAPPSKSVRNLAASNVDIFADVDSVLDTFHFESTPGRVRKPGRRNVSSPSPEPRHRSSSRDGYEQSRYSQRYEHDNSRWSRHNATYRRHEDESRMSRKRSIVRDDFEYSRRHDDGARRRDYYDADIQGDSKRYRGRDASSSSGRSVRFEEEHRRHGDEYRDPRGPRDYNDYGRRRNHANSRSGEDEEKLNAIVRREKELRNRLQKSQKASSSSYRHRSNSSDAEESLNEWDIENQELLDNSMMFGDGIPKRSNARKDKFVKKQATRSKPANSTKSPAQARKKKRASLEDNRDLNDSIACNRPRRSCVTPVAKKITWRKQDLDRLKRVIALKKPSASDADWTEVLRLLAKEGVVEPEVVRQIAITRLKWVEPEQNEEVLKQVEEVEQKRRRGAVARVKENVKMHEELREGGNHRAEDLQSGVESMEDYQPEDVAADQSLLALRTPIVTKKRGGTRASIMPKPVEDSPMSRGNNSTFNSPRLEQTKAKDIETNFKYVQHLSMMQARPSSRLKKSSSMNNSTYRGNKNTSISLEKGTQKALKIINRGTTIHEDDENEDNDDDDDMREEDTSIY
Protein: Probable galactarate/D-glucarate transporter GudP (Q46916)
Organism: Escherichia coli (strain K12)
Function: Probably involved in the uptake of galactarate and/or D-glucarate (Probable). May also transport D-glycerate (Probable).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glucarate dehydratase-related protein
- Glucarate dehydratase
- Galactarate dehydratase
- 5-keto-4-deoxy-D-glucarate aldolase
- Probable galactarate/D-glucarate transporter GarP
- 2-hydroxy-3-oxopropionate reductase
Sequence:
MSSLSQAASSVEKRTNARYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIIVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGIVISFIWLKVIHEPNQHPGVNKKELEYIAAGGALINMDQQNTKVKVPFSVKWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIGGVLGGIISDWLMRRTGSLNIARKTPIVMGMLLSMVMVFCNYVNVEWMIIGFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVHALIAVLSYLVLVGDIKRIELKPVAGQ
Protein: Transcriptional regulatory protein LGE1 (Large cells protein 1) (Q02796)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required to activate transcription of PDR3, a gene involved in retrograde regulation of multidrug resistance, a phenomenon that takes place in cells that have lost their mitochondrial genome. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear and is independent of retrograde regulation of multidrug resistance function.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- E3 ubiquitin-protein ligase BRE1
- Ubiquitin-conjugating enzyme E2 2
- Histone H2A.Z
- COMPASS component SWD3
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- Ubiquitin carboxyl-terminal hydrolase 8
- Helicase SWR1
- Vacuolar protein sorting-associated protein 71
- COMPASS component SDC1
- Actin-like protein ARP6
Sequence:
MSGYTGNNYSRYSSTPPRQRGGYHHARRSRGGAGGSYYRGGNASYGARYNSDYEQPPQEGDLRQTGAYYRNGYTDTRPYYSANSRHYQAQPSPRYNNGTNSYHLPQRGNSQDTNGRTTSASQEDNDEKRVKSRYRNMQADHPRQQPMSVGSTSSRNGSSGNSSTSSTSNGLPPPPSVSSITNNRSYHSSAYPYSSSHTYNNYHHRETPPPPPSNGYYAKGYPVHVPENRSNSDGSSSSVVKKKRILDMKDSPFIYLTDFDKNVKKTNNTESECEKAREVFKESDSIDSALEELNLKINSNELELRLLNNQCDKHALNIQLTQEKLDSLLLMQ
Protein: Glucosidase 2 subunit beta (K7ELL7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLLPLLLLLPMCWAVEVKRPRGVSLTNHHFYDESKPFTCLDGSATIPFDQVNDDYCDCKDGSDEPGTAACPNGSFHCTNTGYKPLYIPSNRVNDGVCDCCDGTDEYNSGVICENTCKEKGRKERESLQQMAEVTREGFRLKKILIEDWKKAREEKQKKLIELQAGKKSLEDQVEMLRTVKEEAEKPEREAKEQHQKLWEEQLAAAKAQQEQELAADAFKELDDDMDGTVSVTELQTHPELDTDGDGALSEAEAQALLSGDTQTDATSFYDRVWAAIRDKYRSEALPTDLPAPSAPDLTEPKEEQPPVPSSPTEEEEEEEEEEEEEAEEEEEEEDSEVQGEQPKEAPPPLSPPQPASPAEEDKMPPYDEQTQAFIDAAQEARNKFEEAERSLKDMEESIRNLEQEISFDFGPNGEFAYLYSQCYELTTNEYVYRLCPFKLVSQKPKLGGSPTSLGTWGSWIGPDHDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKETMVTSTTEPSRCEYLMELMTPAACPEPPPEAPTEDDHDEL