wanglab/gogpt-training-data huggingface dataset:
Protein: Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14) (Type I keratin Ka14) (Q6IFV1)
Organism: Rattus norvegicus (Rat)
Function: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P02533}. Nucleus {ECO:0000250|UniProtKB:P02533}. Note=Expressed in both as a filamentous pattern. {ECO:0000250|UniProtKB:P02533}.
Interaction partners:
- Keratin, type II cytoskeletal 5
- Tumor protein 63
- Keratin, type I cytoskeletal 15
- Keratin 36
- Type I keratin KA11
Sequence:
MATCSRQFTSSSSMKGSCGIGGGSSRMSSVLAGGSCRAPSTYGGMSRFSSAGAYAVGSGYGGGFSSSSFGGGFGGGIGGGIGGGLGGGIGGGFGGGIGGGFGGGIGSGFGGGLGDGLLVGSEKVTMQNLNDRLATYLDKVRALEEANSDLEVKIRDWYQRQRPTEIKDYSPYFKTIEDLKSKILAATVDNANVLLQIDNARLAADDFRTKFETEQSLRINVESDINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMASMRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSAQFSSSSQFSSGSQSSRDVTSTNRQIRTKVMDVHDGKVVSTHEQVLRTKN
Protein: Protein phosphatase 2C, putative (EC 3.1.3.16) (Q583I2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Ubiquitin-conjugating enzyme E2, putative
- Anaphase-promoting complex subunit 4 WD40 domain-containing protein
- Leucine-rich repeat protein
Sequence:
MHQHGKTSGTDGSGATVSQSSSGFMETPWRIFEYGVASEQGSRKTMEDQHAMVAESFPFFAVYDGHGGTQCAEFLRDNLHTFIFGQPEIETDPERATRAGIAEAENAFLTKCADEKIESGSTCAVALVVDDTLIAGNVGDSEIVLCRAGAPIVLSTKHSIQDNVSEGERVKACGGRIISNRVGHPKFNPQLLSLAITRAIGDAGFKLREFTDGKPSGVIADAETRSTRLTDDDKFLIIGCDGLWDVMSYEAAVQLCSRLASEGETPKAIAGSLCQEALRQGSTDNVTCIYINIRAKSSAPGCGQLGSGDPLHNM
Protein: Isthmin-1 (Q5EGE1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May specifically influence certain angiogenesis process.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Serine palmitoyltransferase, long chain base subunit 1.
- Sushi domain containing 2.
- Kinesin family member 16Bb
- 3-dehydrosphinganine reductase
- Sorbitol dehydrogenase
- BTB
Sequence:
MVRLAAELLLLLGLLLLTLHITVLRSSPLQHGNDTVSLEQDSRVAENNVNADSSSSVQLGPGDRQTRVAHIPASQPWAQSPGTGGSLQRDGPGAFLLDLQNFPDLSKADINGQNPNIQVTIEVVDSLEGSEPEKGMRKENKPGWAAPNWRNWWQRSSSSSSSSVSTPKGPEEQDYPYESNTEDSNFLKPLGDWERRVKSEAGAGSRTQTEYDYIDGEGDWSAWSPCSVSCGNGNQKRTRSCGYACTATESRTCDMPSCPGIEDAFKTAATEVSLLAGTEEFNATELFGVDTDSCERWMNCKSEFLKKYMSKVATDLPSCPCFYPTEVAYSTADVHDANTKRNFRWKDASGPKEKLEIYKPTARYCIRSMLTLESTTLAAQHCCYDDSMKLITRGKGAGTPNLISTEFSADLHYKVDILPWIICKGDWSRYNHARPPNNGQKCAENPQDEDYYKQFEEAREF
Protein: AF4/FMR2 family member 2 (Protein FMR-2) (FMR2P) (Protein Ox19) (P51816)
Organism: Homo sapiens (Human)
Function: RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:19136466}. Note=When splicing is inhibited, accumulates in enlarged speckles.
Interaction partners:
- Transmembrane protein 185A
- Fragile X messenger ribonucleoprotein 1
Sequence:
MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEYTNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL
Protein: RH03361p (Q8SZM6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MADGEYDKEQLRILRNAFKAFDHDGAGSIEHADVSSILEILGQKLEPPAVKALIKEVDKGTTGKLDFSQFCKLAARFIEVEEDVGALQNELKEAFRVYDKEGKGYLTVATLRGILHELDDKLSNQDLDMIIEEIDADGSGTVDFDEFMQVMAG
Protein: Anti-adapter protein SpxO (O32302)
Organism: Bacillus subtilis (strain 168)
Function: Inhibitor of Spx proteolytic control. Acts by interacting with SpxH/YjbH, which disrups interaction between SpxH and Spx, and inhibits SpxH-enhanced proteolysis of Spx by ClpXP. Required for the stabilization of Spx and activation of Spx-regulated genes in response to cell wall stress.
Interaction partners:
Sequence:
MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTNYRDFNGYSFT
Protein: Cytochrome C oxidase assembly protein COX17 (RCG52925, isoform CRA_d) (Q76MV3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Interaction partners:
- Cytochrome c oxidase copper chaperone COX11
- Copper transport protein ATOX1
- Mitochondrial intermembrane space import and assembly protein 40
- Synthesis of cytochrome C oxidase 1
- Copper chaperone for superoxide dismutase
- Copper-transporting ATPase 1
- High affinity copper uptake protein 1
- Cytochrome c oxidase assembly protein COX19
- Copper-transporting ATPase 2
- Mitochondrial intermembrane space import and assembly protein 40
Sequence:
MPGLAAASPAPPEAQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
Protein: Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13) (Q9BS18)
Organism: Homo sapiens (Human)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cell division cycle protein 16 homolog
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 4
- Cell division cycle protein 27 homolog
- Cell division cycle protein 23 homolog
- Anaphase-promoting complex subunit 16
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit CDC26
- Anaphase-promoting complex subunit 15
Sequence:
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN
Protein: Cytochrome c biogenesis CcmF C-terminal-like mitochondrial protein (Cytochrome c biogenesis orf452) (P93286)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Forms a complex with CCMFN1, CCMFN2 and CCMH that performs the assembly of heme with c-type apocytochromes in mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:18644794}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome c biogenesis B.
- Putative cytochrome c biogenesis ccmB-like mitochondrial protein
- Maturase
- Putative cytochrome c biosynthesis ccmC-like mitochondrial protein
- Putative cytochrome c biosynthesis ccmC-like mitochondrial protein
- Putative cytochrome c biosynthesis ccmC-like mitochondrial protein
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 1
Sequence:
MVQLHNFFFFIIFMVVLCGTAAPVLLKWFVSRDVSTGAPFFNGTIIPILISLFSLLVYLHSRKIIRSMDGAKSGVLVRASRPILLPDIIGRSSSETRARKALFFFVPVLHFCLLESKGDFSYLESFCGVLCLLFFCTFFFLARDRSAKRERARRRKGQTLRPNGNEQRRNDKMRCSGHPHLDLERRVEGFGPLAFPVPPELGGACVGGVPPEIGLEALALPRSRQLMAMAVGHDYYQKVPMKMNISHGGVCICMLGVLLSNTKKIQFTQRLPLGYELHMGKERCCLRGLDHLHGPTFHSICGNLMIYKPSLTNDRLMFEHDESLHADLLLINFPASYKNGKLEHFLHWWMKNRKHNNFWLTMFPEKRYFRERTSTAEVAIHTNLFTDLYALIGTGSSRTGGWYTTIMKLPFIFFIWIGFMLASLGGLPSLLRQLQKDKLRWN
Protein: Tryparedoxin peroxidase (Q4QF76)
Organism: Leishmania major
Interaction partners:
- Trypanothione synthetase
- Trypanothione reductase
- Tryparedoxin
- Tryparedoxin
Sequence:
MSCGNAKINSPAPSFEEVALMPNGSFKKISLSSYKGKWVVLFFYPLDFTFVCPTEVIAFSDSVSRFNELNCEVLACSIDSEYAHLQWTLQDRKKGGLGTMAIPMLADKTKSIARSYGVLEESQGVAYRGLFIIDPHGMLRQITVNDMPVGRSVEEVLRLLEAFQFVEKHGEVCPANWKKGAPTMKPEPNASVEGYFSKQ
Protein: Relaxin-3 receptor 1 (RLN3 receptor 1) (G protein-coupled receptor SALPR homolog) (Relaxin family peptide receptor 3) (Q8BGE9)
Organism: Mus musculus (Mouse)
Function: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Relaxin-3
- Relaxin receptor 1
- Relaxin receptor 2
- Prorelaxin 1
- Insulin-like 3
- Insulin-like peptide INSL5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Beta-arrestin-2
Sequence:
MQVASATPAATVRKAAAGDELSEFFALTPDLLEVANASGNASLQLQDLWWELGLELPDGAAPGHPPGGGGAESTDTEARVRILISAVYWVVCALGLAGNLLVLYLMKSKQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVARYHSVASALKSHRTRGRGRGDCCGQSLRESCCFSAKVLCGLIWASAALASLPNAIFSTTIRVLGEELCLMHFPDKLLGWDRQFWLGLYHLQKVLLGFLLPLSIISLCYLLLVRFISDRRVVGTTDAVGAAAAPGGGLSTASARRRSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFQCQVYAFPVSVCLAHSNSCLNPILYCLVRREFRKALKNLLWRIASPSLTNMRPFTATTKPEPEDHGLQALAPLNAAAEPDLIYYPPGVVVYSGGRYDLLPSSSAY
Protein: Aryl hydrocarbon receptor repressor (AhR repressor) (AhRR) (Q3U1U7)
Organism: Mus musculus (Mouse)
Function: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9887096}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:9887096}. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
Interaction partners:
- Aryl hydrocarbon receptor nuclear translocator
- AH receptor-interacting protein
- Aryl hydrocarbon receptor nuclear translocator 2
- Heat shock protein HSP 90-beta
- Cytochrome P450 1A1
- Basic helix-loop-helix ARNT-like protein 2
- Basic helix-loop-helix ARNT-like protein 1
- Cytochrome P450 1B1
Sequence:
MMIPSGECTYAGRKRRKPIQKRRLTMGAEKSNPSKRHRDRLNTELDHLASLLPFSPDIISKLDKLSVLRLSVSYLRVKSFFQALQETCVWSAPALSPEEHSYRGFPVQEGRLLLESLNGFALVVSAEGMIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQSPHADTDNTVLGKLLRAQEGGKGLPSEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKTPSGTALPPRLSLFCIVAPVLPSVTEMKMKSTFLKAKHRADIVVTMDSRAKAVTSLCESELHPKLNYLAGKSNGENGISLFRGQTDRSHWARALARSSCLCLRGGPDLLDPKGTSGDREEEDQKHILRRSPGAWGQREMHKYSYGLETPVHLRHLNWSTEQRSQESTTKLTRQPSKNEPSTCLVPHGSCVPYPGSQGMLSASNMASFRDSLDHPTGAYCSQMNRPLSDIHQGQVDPSTCHISQGSLGSRIPLTGMQRFTARGFSTEDAKLPSLPVTIGTPCNPVLSLDVPIKMENESGSQDIVEASTTSCLWLGTSDMARGHLVGFPARMHLKTEPDYRQQACTPHLGHGMLGTNPYSRDTVGSCREHAPLYSAHCTCLDPEPPHHLFMCSHSESQHPSLDQDCRAPIVKREPLDSPSWAAPGQVTVPRMFPKSASKTVIPSKGSDGIFLP
Protein: Small ribosomal subunit biogenesis GTPase RsgA 1, mitochondrial (EC 3.6.1.-) (Protein EMBRYO DEFECTIVE 1688) (Q4V399)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit (By similarity). Required for embryo development.
Subcellular location: Mitochondrion {ECO:0000255}.
Interaction partners:
- Thiamine pyrophosphokinase 2
- Thiamine pyrophosphokinase 1
- Thiamine biosynthetic bifunctional enzyme TH1
- Bifunctional TH2 protein, mitochondrial
- Adenylate kinase 5, chloroplastic
- Adenylate kinase 2, chloroplastic
- Embryo defective 1703
- Probable adenylate kinase 6, chloroplastic
- Probable adenylate kinase 7, mitochondrial
- Adenylate kinase 3
Sequence:
MLRAKHIGKNYSSSLSPVLSPEHKPSLLESQAIGTVATAQANFMRVIVQDVANSVTSDDDNDSSKTGVELLCVVRAVLKKIRRRVLVGDKVLVGSIDWVDRRGMIENVFHRRSEILDPPVANVDHLLVLFSLDQPKLEPFTLTRFLVEAESTRIPLTLALNKTELISEEELETWKIRLRGWNYEPLFCSVGTKDGLDDIAFVLRDQTSVIVGPSGVGKSSLINVLRSNHGGGVVEDENWFEPMLGNKWFDDQRVGEVSSRSGRGKHTTRNVSLLPVSEGGYLADTPGFNQPSLLKVTKHSLAHCFPEIRNMIESEKCGFRDCLHIGEPGCVVKGDWERYPYYLQLLDEIRIREEFQLRTFGTKREDDVRYKVGDMGVKHAEPRLMPKKHRRESRKKTKQTMISELDEFEDEDSDLYIENDPIVQAIENENKRQ
Protein: Radial spoke protein RSP9 (Q57YF0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- AP-4 complex subunit epsilon
- AP-1 complex subunit gamma
- AP complex subunit sigma
- AP complex subunit sigma
- AP complex subunit beta
- AP complex subunit beta
Sequence:
MSSVSDCIFGLPYVGKALSTAERAALQSSLPLLALKYNLPVQFWGKVTGVRGDYLVAQVMPNGLFGARHSFFSVDGGTSWRVLETLSEDQVAFCDQLRGVYIGDPSFLYKVRRDIPPEPEPEVKVPDAEDLLKDAKEKYGGEGEENEEDMEEEEEEEEEEQDEGELEEEEEEVEEEPPRKKRPKFMIVAVPETIRLAHFIGLHDRACSLIVRGQYVFTPAGDVEKNTLFAGQPTRHAMKPSCYLRVFHAGNPERNRILYGPTYSSVTDRLSPITDDEPRGVWVVKYEPTASIVTVENLLYPGSLFWYRPGSKDCGQVYCGSGERDFEVCFLLP
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (Q6ZM60)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}. Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004326}.
Interaction partners:
- Histidine-rich calcium-binding protein
Sequence:
MENAHTKTVEEVYSFFAVNESTGLGLEQVKRQREKWGPNGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKTVQRIKARDIVPGDIVEVAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGVVVATGVNTEIGKIRDEMASTEQERTPLQQKLDEFGQQLSKVISLICIAVWIINIGHFNDPVHGGSWVRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFIVDQANGNTCSLKEFSISGSTYAPDGQVCHEGKPVQCSKFDALVEMASICALCNDSSLDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKVERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKARSSMGKMFVKGAPEGVIDRCTHIRVGGNKVPMTPGIKEKIMSVIREYGTGRDTLRCLALATRDNPLSKESLVLEDSTRFVEYETDLTFVGCVGMLDPPRAEVAASIKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGENDDVSRMAYTGREFDDLSAAAQREAVLTARCFARVEPSHKSKIVEFLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMSKPPRNAREPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAAEDGPRVTFYQLSHFLQCAPDNPEFEGLQCEIFGSPYPMTMALSVLVTIEMCNALNSVSENQSLLHMPPWENVWLLGAICLSMSLHFLILYVEPLPMIFQITPLNVTQWLMVLKISLPVILLDEVLKFAARNYLDKPKDLDNPKGKACSLSACTEGISWPFVALSLPLVLWIYSTDTNVAELFWS
Protein: Prostaglandin E synthase 2 (EC 5.3.99.3) (Microsomal prostaglandin E synthase 2) (Q9FHX0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037847}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037847}.
Interaction partners:
- Short-chain dehydrogenase/reductase
- NAD
- Short-chain dehydrogenase/reductase
- ATP-dependent zinc metalloprotease FTSH 10, mitochondrial
- MD-2-related lipid-recognition protein 3
- Large ribosomal subunit protein mL101
- Protein disulfide-isomerase 2-3
Sequence:
MRRVTGLAARTISSSVAINSRLTQSMAITTISSSEPISRRFGGLPEIKTPSFAGGVAGVVFFSAAAVSSLGQEVHAKEMAQKFNPKEVVLYQYEACPFCNKVKAFLDYNKIPYKVVEVNPISKKEIKWSDYKKVPILTVDGEQMVDSSVIIDSLFQKMHPEISKSEDDEETKWRKWVDNHLVHLLSPNIYRNTSEALESFEYITTHGNFSFTERLVAKYAGATAMYFVSKKLKKKYNITDERAALYDAAETWVDALKERPYLGGSKPNLGDLAVFGVLRPIRYLRSGKDMVDNTRIGEWYSRMENTVGEPSRIKE
Protein: Small proline-rich protein 2E (O70556)
Organism: Mus musculus (Mouse)
Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Small proline-rich protein 2D
Sequence:
MSYQQQQCKQPCQPPPVCPPKKCPEPCPHPQCPEPCPPPKCPEPCPEPCPPPSYQQKCPPVQPPPPCQQKCPPKSK
Protein: Catabolite repression protein creC (Q9P4R5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.
Interaction partners:
- HECT-type ubiquitin ligase-interacting protein creD
- DNA-binding protein creA
- Ubiquitin carboxyl-terminal hydrolase creB
- WD repeat protein
- E3 ubiquitin-protein ligase RSP5
- Xylanolytic transcriptional activator xlnR
- Adenylate cyclase
- Mitochondrial Rho GTPase 1
- Exo-1,4-beta-xylosidase xlnD
- Probable beta-glucosidase A
Sequence:
MFVLPPPPPRYTVPVAYAAGASNGMAVPIVETNNIITHPEKGCPLQVGEGTYQLQDDLHLATPPPHPSEAPIINPNPLATVPNPPTSGVKLSLISLGLRNKTAFPSKVQVTARPFGDGNSALAAAPVKDPSKKRKPKNNIIKSSSSFVSRVIIHEATTKRLNDRDPEGLFAFANINRAFQWLDLSSKHKDEPLSKILFTKAHMISHDVNEITKSSAHIDVIMGSSAGDIFWYEPISQKYARINKNGIINSSPVTHIKWIPGSENFFIAAHENGQLVVYDKEKEDALFIPELPEQSAESVKPSRWSLQVLKSVNSKNQKANPVAVWRLANQKITQFAFSPDHRHLAVVLEDGTLRLMDYLQEEVLDVFRSYYGGFTCVCWSPDGKYIVTGGQDDLVTIWSLPERKIIARCQGHDSWVSAVAFDPWRCDERTYRIGSVGDDCNLLLWDFSVGMLHRPKVHHQTSARHRTSLIAPSSQQPNRHRADSSGNRMRSDSQRTAADSESAPDQPVQHPVESRARTALLPPIMSKAVGEDPICWLGFQEDTIMTSSLEGHIRTWDRPRENISDNYGDQKSSETLGTGKEAGHPASSMGSL
Protein: Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Protein SEC34) (P40094)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis- Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG3 is also involved in actin cytoskeleton organization.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:10562277, ECO:0000269|PubMed:10588657}; Peripheral membrane protein {ECO:0000269|PubMed:10562277, ECO:0000269|PubMed:10588657}; Cytoplasmic side {ECO:0000269|PubMed:10562277, ECO:0000269|PubMed:10588657}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 2
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 4
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 5
- Conserved oligomeric Golgi complex subunit 7
- Coatomer subunit beta
- Protein SLY1
- Integral membrane protein SED5
Sequence:
MARSRKNSLVRDIASHPTIPESQTIVGLLDDSYLFDKLKKLSLAVENSDSLQRTDVSEGCSEVNGSEATTSADVKKTNKYLYYTTYLDQLNIKIDEYKVVLDQTRQVNDQLDSSIKKFRKISQDTGAFIEETKTIYEKQSKLSNLTESIPKALHYFEVLDPIMRRLNHATSPAIVKKSSFTTMLATIDESLRFLDENSDLKDAAAYRIKFKQCLIRACELISHFLTNLLKQTNQEILDKTKNKNSLTGLPSTTRDAFLYSKFYTIADTFKIQVSEIVKRSNEKAYNKYHDELNSILYECFNHYFQTRLRLLTPVIWSHIDEIVVKDKDQGLVKFIQDGKVYFQQLCADEYKLFVEFFPEKECRFKINQWFLQLCEPLYDSIRVRVLKETDICTLCDSVTLFAPYYEFEEGSEEYVKQFTDIQYDKLFEPIVQKVQARLILRVQIYVQQNILSYRPTRDVFMISNRRRKSKTSLQGGNEDATTSDDNPDPLLESYLSSFKNRSILPISPNDADDKSIDSEESTDKISQLQTYYPPLLKTLALLSKIYEMINSVVFDDLAHHVVHDCIVSLRNAYDMVIKSSAGKSDFNNLDISLAYLKNLLMLRDSIQNFNIQYTVNETYLDFSGVEGFFKSLKENGRNVLKKTKSSSILTLARELVPKVVNNMVDARTELISELRNVIKDFTESTSLELIDDTLDINSDEDLLSKNVKLRENIKARLPRIYEQILNYIDDQEIVTNLLDAVQELITQSYSKYYETITELAENGKFAKDQVADVMYLDVFTDFFAKEVADLLRNGDIDTITK
Protein: DnaJ-related protein rsp1 (O13601)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in the proper organization of the interphase microtubule cytoskeleton. Required for equatorial microtubule organizing center (eMTOC) disassembly into satellites, contributing to the dynamic redistribution of MTOC components for organization of interphase microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15068790}. Nucleus {ECO:0000269|PubMed:15068790}. Note=Associates with the microtubule bundles.
Interaction partners:
- Gamma tubulin complex adapter mto1
- Gamma tubulin complex adapter mto2
- Probable heat shock protein ssa1
- Spindle pole body component alp16
Sequence:
MARTAFHDEFVDYYTILGAESTSSYVEIRQQYLKLVLRYHPDRNPGREAEVLPQFQLIQKAHEVLKDPKLRELFDQRRLLEAGRPDGVLRFRPKKSGPKNDISTKVASKVSVTMATKFAEKKKKQDRENVDSKDNNITNFSLHRSFSASGKMEKNNSFKEVSTSKSYISSGYLHPKTSPIFKKNGYATENVVDPISSSPRFKGPNYNKFNAKLYLESLREKRRTYTPLSEISNGLNSNGVENSSITKSSPRSSSSSNNERFKDTSEESIIFTSPNTPEHPSVYQTDITPEIKLEHSDNNSPSKPEIPFRHPTSKPLPPKPLSRSKSSSLSRNQTRSQLNDLSAENDSTSNSTEYDDQLQSILRSLAIEGDDDEVAKVLPKPPSVPTIQAPIPPEAPRNLTNASVDSYLNSFEMYQRRWSSYSIIYTQYAFQWQIFKNKCFQLDLMNTPGQSRLIDNWKEGSQAIQLFYAYEQMHLRALEELQSLKESLFASFGI
Protein: Protein PHR1-LIKE 1 (Myb-like transcription factor 1) (Q8GUN5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor acting as central integrator of phosphate starvation responses. Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SPX domain-containing protein 1
- SPX domain-containing protein 2
- Inorganic phosphate transporter 1-1
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase VIP2
- Probable ubiquitin-conjugating enzyme E2 24
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase VIP1
- Phosphate transporter PHO1
- SEC12-like protein 1
- Inositol-3-phosphate synthase isozyme 1
- Phosphate transporter PHO1 homolog 1
Sequence:
MTLANDFGYSTAMSSSYSALHTSVEDRYHKLPNSFWVSSGQELMNNPVPCQSVSGGNSGGYLFPSSSGYCNVSAVLPHGRNLQNQPPVSTVPRDRLAMQDCPLIAQSSLINHHPQEFIDPLHEFFDFSDHVPVQNLQAESSGVRVDSSVELHKKSEWQDWADQLISVDDGSEPNWSELLGDSSSHNPNSEIPTPFLDVPRLDITANQQQQMVSSEDQLSGRNSSSSVATSKQRMRWTPELHEAFVEAVNQLGGSERATPKAVLKLLNNPGLTIYHVKSHLQKYRTARYKPETSEVTGEPQEKKMTSIEDIKSLDMKTSVEITQALRLQMEVQKRLHEQLEIQRSLQLQIEKQGRYLQMMFEKQQKIQDNKSSSSEASPKQCNGSFAEVEVGLETLTGDQNESASASRKRVRED
Protein: Cysteine peptidase C (CPC) (EC 3.4.22.-) (D6XHE1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Clathrin heavy chain
- Mitochondrial processing peptidase, beta subunit, putative
Sequence:
MHLMRACITFCIASTAVVAVNAALVAEDAPVLSKAFVDRVNRLNRGIWKAKYDGVMQNITLREAKRLNGVIKKNNNASILPKRRFTEEEARAPLPSSFDSAEAWPNCPTIPQIADQSACGSCWAVAAASAMSDRFCTMGGVQDVHISAGDLLACCSDCGDGCNGGDPDRAWAYFSSTGLVSDYCQPYPFPHCSHHSKSKNGYPPCSQFNFDTPKCNYTCDDPTIPVVNYRSWTSYALQGEDDYMRELFFRGPFEVAFDVYEDFIAYNSGVYHHVSGQYLGGHAVRLVGWGTSNGVPYWKIANSWNTEWGMDGYFLIRRGSSECGIEDGGSAGIPLAPNTA