wanglab/gogpt-training-data huggingface dataset:
Protein: DELLA protein RGL3 (GRAS family protein 27) (AtGRAS-27) (RGA-like protein 3) (Q9LF53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. No effect of the BOI proteins on its stability. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes. Its activity may be regulated by phytohormones such as auxin and ethylene (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Gibberellin receptor GID1A
- F-box protein GID2
- Transcription factor PIF3
- Gibberellin receptor GID1B
- Gibberellin receptor GID1C
- Transcription factor PIF4
- Transcription factor MYC2
- Transcription factor PIF5
- Protein BRASSINAZOLE-RESISTANT 1
- Gibberellin 3-beta-dioxygenase 1
Sequence:
MKRSHQETSVEEEAPSMVEKLENGCGGGGDDNMDEFLAVLGYKVRSSDMADVAQKLEQLEMVLSNDIASSSNAFNDTVHYNPSDLSGWAQSMLSDLNYYPDLDPNRICDLRPITDDDECCSSNSNSNKRIRLGPWCDSVTSESTRSVVLIEETGVRLVQALVACAEAVQLENLSLADALVKRVGLLAASQAGAMGKVATYFAEALARRIYRIHPSAAAIDPSFEEILQMNFYDSCPYLKFAHFTANQAILEAVTTSRVVHVIDLGLNQGMQWPALMQALALRPGGPPSFRLTGVGNPSNREGIQELGWKLAQLAQAIGVEFKFNGLTTERLSDLEPDMFETRTESETLVVNSVFELHPVLSQPGSIEKLLATVKAVKPGLVTVVEQEANHNGDVFLDRFNEALHYYSSLFDSLEDGVVIPSQDRVMSEVYLGRQILNLVATEGSDRIERHETLAQWRKRMGSAGFDPVNLGSDAFKQASLLLALSGGGDGYRVEENDGSLMLAWQTKPLIAASAWKLAAELRR
Protein: Gametocyte-specific factor 1 (Protein FAM112B) (Q8WW33)
Organism: Homo sapiens (Human)
Function: Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9DAN6}.
Interaction partners:
- Piwi-like protein 1
- Piwi-like protein 4
- Piwi-like protein 2
Sequence:
MEETYTDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVASKLATCPFNARHQVPRAEISHHISSCDDRSCIEQDVVNQTRSLRQETLAESTWQCPPCDEDWDKDLWEQTSTPFVWGTTHYSDNNSPASNIVTEHKNNLASGMRVPKSLPYVLPWKNNGNAQ
Protein: RNA polymerase sigma factor FliA (O67268)
Organism: Aquifex aeolicus (strain VF5)
Interaction partners:
- Anti sigma factor FlgM
- Flagellar basal-body rod protein FlgC
- Motility protein A
- Flagellar biosynthesis protein FlhA
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta'
- Flagellar hook protein FlgE
- Flagellar hook-associated protein 1
- Flagellar basal body rod protein FlgB
- Basal-body rod modification protein FlgD
Sequence:
MKNPYSNQIEREELILKYLPLVKAIATNIKKHLPEDVDIRDLISYGVIGLIKAVDNLSTENPKRAEAYIKLRIKGAIYDYLRSLDFGSRQVREKERRIKEVVEKLKEKLGREPTDEEVAKELGISTEELFKTLDKINFSYILSLEEVFRDFARDYSELIPSSTNVEEEVIKRELTEKVKEAVSKLPEREKLVIQLIFYEELPAKEVAKILETSVSRVSQLKAKALERLREMLSNPL
Protein: NF-kappa-B inhibitor-interacting Ras-like protein 1 (I-kappa-B-interacting Ras-like protein 1) (Kappa B-Ras protein 1) (KappaB-Ras1) (Q8CEC5)
Organism: Mus musculus (Mouse)
Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- NF-kappa-B inhibitor beta
Sequence:
MGKGCKVVICGLLSVGKTAILEQLLYGNHTIGMEDCETLEDVYMASVETDRGVKEQLHLYDTRGLQKGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGNKLDLSEQRQVDADVAQQWARSEKVKLWEVTVTDRRTLIEPFTLLASKLSQPQSKSSFPLPGRKNKGNSNPEN
Protein: Beta/delta/mu-theraphotoxin-Pv1 (Beta/delta/mu-TRTX-Pv1) (Poecilotheriatoxin-1) (PcaTX-1) (C0HLN4)
Organism: Poecilotheria vittata (Ghost ornamental tarantula) (Poecilotheria pederseni)
Function: Gating-modifier toxin that targets voltage-gated sodium channels. Inhibits the inactivation of Nav1.7/SCN9A.
Subcellular location: Secreted {ECO:0000269|PubMed:32218140}.
Interaction partners:
Sequence:
AGCKYLFGSCKEDSDCCKHLGCRRKAPQYCGWDGTF
Protein: Major surface protein 5 (Q2GJ45)
Organism: Anaplasma phagocytophilum (strain HZ)
Interaction partners:
- Cytochrome c oxidase subunit 2
- Putative thiol-disulfide oxidoreductase
- Cytochrome c homolog
- Putative thiol:disulfide oxidoreductase
- Cytochrome c oxidase assembly protein CtaG
- Major surface protein 4
- Heme A synthase
- Uncharacterized protein
- Chaperonin GroEL
Sequence:
MKTFKTVSNLLLLVATVFLGYSYVNKKGIFSDMGAKLSSTDTVVEQAPILASFTDLINQEGQVVSSTDFAGKHMLLMFGFSSCKHICPAELGMVSQLLNKLGETADKLQAVFITIDPKNDTVERLNEYHKAFDSRIQMLTGDEEVIRNVVNNYKVYVGESDSEGDINHSSFLYLVDADGRYVGHFAPDFDEYESQVGRLFDFVNKYLNS
Protein: Integrin beta-4 (CD antigen CD104) (A2A863)
Organism: Mus musculus (Mouse)
Function: Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction, hemidesmosome {ECO:0000250}. Note=Colocalizes with DST at the leading edge of migrating keratinocytes. {ECO:0000250}.
Interaction partners:
- Integrin alpha-6
- Plectin
- Gamma-aminobutyric acid receptor subunit alpha-6
- Collagen alpha-1
- Integrin alpha-3
- Integrin alpha-7
- Dystonin
- Focal adhesion kinase 1
- Integrin beta-1
- Proto-oncogene tyrosine-protein kinase Src
Sequence:
MAGPCCSPWVKLLLLAAMLSASLPGDLANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQAELLAAGCRGESILVMESSLEITENTQIDTSLHRSQVSPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKPSFSDGLRMDASVICDVCPCELQKEVRSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGRGYCECGRCHCNQQSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRACDDCPFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYNVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLALLLLLCWKYCACCKACLGLLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASTSPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVSGAHKLQQTKFRQQPNTGKKQDHTIVDTVLLAPRSAKQMLLKLTEKQVEQGSFHELKVAPGYYTVTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPSTTTVILGEHDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSDEDGSVAGGVEGEGSGWIRGATPRPPGEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHLSHRVLSTSSTLTRDYHSLTRTEHSHSGTLPRDYSTLTSLSSQDSRGAVGVPDTPTRLVFSALGPTSLKVSWQEPQCDRMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLGSHSGLFQNPVQSEFSSVTSTHSTTTEPFLMDGLTLGTQRLEAGGSLTRHVTQEFVTRTLTASGSLSTHMDQQFFQT
Protein: T. brucei spp.-specific protein (Q57YQ6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQGSTEKTTLEERMIQRRSSLPSLQLPSNSSIPPLSKNSSFAEGRVVSDPKLWTERFNDVFHVPPAHTSPEANCPRGPNKSEEKSPTPEVTCCGLFF
Protein: Seipin-1 (AtSEIPIN1) (Q9FFD9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size. Facilitates the formation of large-sized LDs and modulates triacylglycerol accumulation. Induces probably a reorganization of the endoplasmic reticulum into LD-forming domains.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26362606}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the lipid droplet-forming sites. {ECO:0000269|PubMed:26362606}.
Interaction partners:
- At4g31830
- At4g27530
- Alpha/beta-Hydrolases superfamily protein
- NAD
- REF/SRPP-like protein At1g67360
- Voltage-dependent L-type calcium channel subunit
- REF/SRPP-like protein At3g05500
- 2-oxoglutarate
- Transmembrane 9 superfamily member 8
- Alpha/beta-Hydrolases superfamily protein
Sequence:
MRILQNKTMKEQDNQLKIPEPLRADWFMVLVTIQADLIYNALVVLSSPFFLLYRSYRRAVVTVSAAEKAVKRAPAQIAGGAGRVVRRTWFGILGACHVSMVMVLALILAVVIGVGIVSLYVEKPVVVRDRLFFDYTEENPSAVFSFDKKKRSFSVPVGHSVHVSLVLWMPESEINRRIGVFQLKVELLSLKGETIARSSQPCMLRFRSKPIRLARTFVMSVPLIAGIANEAQTMRIDALKHQEKMPRTKAVRATLIPRAQTRTLPQLYEAEIVINSKPPWIKRMAYNWKWTLCVWTSMYLYVAILTALLWCFRPVLFPYTSSRTISESENLEIEVVEEEQEQVMERRRRERRNQPRRRNFATTQKSYT
Protein: Calnexin homolog (Q6Q487)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Protein disulfide-isomerase
- Endoplasmic reticulum chaperone BiP
- 116 kDa U5 small nuclear ribonucleoprotein component
- UDP-glucose:glycoprotein glucosyltransferase, putative
- Mannosyl-oligosaccharide glucosidase
- Prohibitin
- Prohibitin
- Protein transport protein sec31
- Autophagy-related protein 22-2
- Autophagy-related protein 22-1
Sequence:
MRFNAAITGALVSSATLMGQAHAEETEKKADATSLVEKPTFTPTTIEAPFLEQFTADWDSRWTPSHAKKEDSKSEEDWAYVGEWAVEEPTVLNGMVGDKGLVVKNVAAHHAISAKFPKKIDNKGKTLVVQYEVKPQNSLVCGGAYMKLLQENKKLHAEEFSNATPYVIMFGPDKCGATNKVHFIFRHKNPKTGEYEEKHMTAPPAARTTKLTTLYTLIVKPDQSFQILIDGEAVKNGTLLEDFAPPVNPEKEIDDPKDKKPADWVDEAKIPDPEAKKPDDWDEDAPYEIVDEEATMPEDWLEDEPTSIPDPEAEKPEDWDDEEDGDWIPPTVPNPKCNEVSGCGPWTPPMKKNPAYKGKWTAPLIDNPAYKGIWKPRKIPNPAYFEDKTPSNFEPMGAVGFEIWTMQNDILFDNIYIGHSIEDAEKLRKETFDLKHPVEVALEEASKPKLEEKAATPSVSFKEAPVTYVREKVDYFVGLAKQDPINAVKQVPEVAGGLGALLLTMILVIVGAVGASSPAPAAAAKKGKEAASAAKEKASEAVSSAADTAKGAATKRNTRSSAQ
Protein: B3 domain-containing protein REM10 (Protein REPRODUCTIVE MERISTEM 10) (P0DH85)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00326}.
Interaction partners:
- Putative B3 domain-containing protein At5g58280
- B3 domain-containing protein At5g42700
- B3 domain-containing protein At3g19184
- Putative ubiquitin-like protein
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Ubiquitin family protein
- Large ribosomal subunit protein uL22y
- Purple acid phosphatase 5
- AslB, putative
- Protein FAR1-RELATED SEQUENCE 12
Sequence:
MANPLLYSPINPQFFQPLLPGFTNHLDIPVAFFLKYLVGTNVGKTAELRSDASEMTWKVKIDGRRLSNGWEDFTIAHDLRVGDIVVFRQEGELVFHVTALGPSCCEIQYGEDTLEEDKIEKLCGTENVSSKKKSLKREAESAPDNSLDSCFVATVTGSNLKRDTLYIPKEFALSNGLMNKYQIVLMNEEGESWKIDLRREAYNYGRFYMRRGWRSFCIANGKKPGDVFAFKLVKNEETPMIQLFPMTIEDLDKLQSLPRHKIRKTEAAPSSPDLSSFVATVTASNLSRDRLYLPKTFIMSNGLLKKFQMCLMNEEGESWTIDVKHEAHTGRFLTIRGWRRFCVANGKKPGDLLKFKLVHNEETPVLQLLPLNSEDLHKLNPSNDTRHGQSLKVTKKEFLGMEATENEFLGEEVYCNDSFKASEKDTLPFAEPINEDIRQGQCSQTIKQEYVSTEEKNSTSQNRFVTLTLTHSSKLNLPFEFMKRNGIKKAGKITMVDRYDAKWRTSLLMDKIGTMSLGRGSKGFCEVNGVEMNESFILELIWEDTVPLLKFCSKV
Protein: BiP/GRP78 (Q26733)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MSRMWLTTAAVFLTVTVAAVSAAPESGGKVEAPCVGIDLGTTYSVVGVWQKGDVHIIPNEMGNRITPSVVAFTDTERLIGDGARNQLPQNPHNTIYTIKRLIGRKYTDAAVQADKKLLSYEVIADRDGKPKVQVMVGGKKKQFTPEEISAMVLQKMKEIAETYLGEKVKNAVVTVPAYFNDAQRQSTKDAGTIAGLNVVRIINEPTAAAIAYGLNKAGEKNILVFDLGGGTFDVSLLTIDEGFFEVVATNGDTHLGGEDFDNNMMRHFVDMLKKKKNVDISKDQKALARLRKACEAAKRQLSSHPEARVEVDSLTEGFDFSEKITRAKFEELNMDLFKGTLVPVQRVLEDAKLKKSDIHEIVLVGGSTRVPKVQQLISDFFGGKELNRGINPDEAVAYGAAVQAAVLTGESEVGGRVVLVDVIPLSLGIETVGGVMTKLIERNTQIPTKKSQVFSTHADNQPGVLIQVYEGERQLTKDNRLLGKFELSGIPPAARGVPQIEVTFDVDENSILQVSAMDKSSGKKEEITITNDKGRLSEEEIERMVREAAEFEDEDRKVRERVDARNSLESVAYSLRNQVNDKDKLGGKLDPNDKAAVETAVAEAIRFLDENPNAEKEEYKTALETLQSVTNPIIQKTYQSAGGGDKPQPMDDL
Protein: Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92) (Q9Y2X0)
Organism: Homo sapiens (Human)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 27
Sequence:
MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACVTSRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP
Protein: Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Q9WVM1)
Organism: Mus musculus (Mouse)
Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Has a critical role in erythropoiesis (By similarity). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:12590651}. Cytoplasm {ECO:0000269|PubMed:12590651}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12590651}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12590651}. Cleavage furrow {ECO:0000250|UniProtKB:Q9H0H5}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q9H0H5}. Cell membrane {ECO:0000250|UniProtKB:Q9H0H5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H0H5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H0H5}. Note=During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody ring, also called Flemming body. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase (By similarity). Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome. {ECO:0000250|UniProtKB:Q9H0H5}.
Interaction partners:
- Kinesin-like protein KIF23
- Protein ECT2
- Kinesin-like protein KIF20A
- Anillin
- Protein regulator of cytokinesis 1
- Kinesin-like protein KIF11
- Kinesin-like protein KIF20B
- Centrosomal protein of 55 kDa
- Aurora kinase B
- Inner centromere protein
Sequence:
MDTTMVNLWTLFEQLVRRMEIINEGNESIEFIQVVKDFEDFRKKYQRTNQELEKFKDLLLKAETGRSALDVKLKHARNQVDVEIKRRQRAEAECAKLEQQIQLIRDILMCDTSGSIQLSEEQKSALAFLNRGQASSGHAGNNRLSTIDESGSILSDISFDKTDESLDWDSSLVKNFKMKKREKRRSNSRQFIDGPPGPVKKTCSIGSTVDQANESIVAKTTVTVPSDGGPIEAVSTIETLPSWTRSRGKSGPLQPVNSDSALNSRPLEPRTDTDNLGTPQNTGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRLVSHPECRDRCPLPCIPPLVGTPVKIGEGMLADFVSQASPMIPAIVVSCVNEIEQRGLTEAGLYRISGCDRTVKELKEKFLKVKTVPLLSKVDDIHVICSLLKDFLRNLKEPLLTFWLSKAFMEAAEITDEDNSTAAMYQAVSELPQANRDTLAFLMIHLQRVSQSPDTKMDIANLAKVFGPTIVAHTVPNPDPVTMFQDIKRQLKVVERLLSLPLEYWNQFMMVDQENIDSQRGNGNSTPRTPDVKVSLLGPVTTPEFQLVKTPLSSSLSQRLYNLSKSTPRFGNKSKSATNLGQQGKFFPAPYLK
Protein: UDP glucuronosyltransferase 5 family polypeptide b2 (D3XDA0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MNGQWFQVIWPITLTLLLPSVPVAQCGKVLVFPVDGSHWVNMNILVEALSAKGHDVTVMRTASSCYIKEFSPHYTSINLKSEGGYNKEVLEQFASRIMHILRDGSTWGHLKLQADMWQSFLKIFEAEREMIVNMIEDQQLMLSLKDAKYDLILTDPNMFGGVILGHYLKLPMVYNVRWAGYNEAHFSIAPSPLSYVPMPSLELSDRMSFLQRVYNVVMYIFIEIGAALVISPINDALAERFIGPGTSFLSLVQGADLWLHRVDFVFEYPRPTMPNVIYMAGFQCKPSKPLPQDLEDFVQSSGDHGVIIMSLGTLIDKLPDDVAEAIAEAFAELPQEIIWRYKGKRPSALGNNTLIMDWMPQNDLLGHPKTRAFVAHGGTNGIQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMNKESFLTTVKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMLWYSYHSVDVILVLISAVSLIILSIYAVIRYFCCRICMRKTKIKHE
Protein: Global transcriptional regulator CodY (Q97PM1)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
Interaction partners:
Sequence:
MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIFPIESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY
Protein: Nicotinate dehydrogenase subunit B (EC 1.17.2.1) (Nicotinate degradation protein B) (Nicotinate dehydrogenase large subunit) (Q88FX8)
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Function: Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation, the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6-hydroxynicotinate (6HNA).
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Nicotinate dehydrogenase subunit A
- 6-hydroxynicotinate 3-monooxygenase
- Nicotinate phosphoribosyltransferase
- Isoquinoline 1-oxidoreductase subunit alpha
- Isoquinoline 1-oxidoreductase subunit alpha
- 2,5-dihydroxypyridine 5,6-dioxygenase
- Putative metabolite transport protein NicT
- Maleate isomerase
- Porin-like protein NicP
- N-formylmaleamate deformylase
Sequence:
MNHSQQVPSRDQLLAKTGVLLIVDQITPPSGPVAKGVTPTVKERELALFIAVSDDGMVYAFNGHVDLGTGIRTSLAQIVAEELDLRMDQVHMVLGDTERAPNQGATIASATLQISAVPLRKAAATARRYLLQQAALRLGCPPEMLRIEDGTVIASNGSTLSFAELVQGKNHQLHIADDAPLKAIEDYRLVGRSAPRVDIPGKATGELTYVHDMRLPNMLHGRVIRPPYAGHDSGDFVGNSLLAVDESSIAHLPGVVAVVVIRDFVGVVAEREEQAIRAAHELKVSWKPFTGKLPDLSDVAQAIRDNPRVQRTVLDQGDVDGGIANASQRLSRSYLWPYQLHASIGPSCALADFTAGQIRVWSGTQNPHLLRADLAWLLACDEARIEIIRMEAAGCYGRNCADDVCADAVLLSRAVQRPVRVQLTREQEHVWEPKGTAQLMEIDGGLNADGSVAAYDFQTSYPSNGAPTLALLLTGAVEPVPALFEMGDRTSIPPYDYEHMRVTINDMTPLVRASWMRGVSAMPNSFAHESYIDELAFAAGVDPVEYRLKHLSDPRAIDLVKATAERAQWQPHTRPMQTQAEGDVLRGRGFAYARYIHSKFPGFGAAWAAWVADVAVDRRTGEVAVTRVVIGHDAGMMVNPEGVRHQIHGNVIQSTSRVLKEQVSFEESTVASKEWGGYPILTFPELPAIDVMMLPRQHEPPMGSGESASVPSAAAIANAIFDATGIRFRELPITAERVRAALGGEGQGPDAPAPAQPSTKRSKWWFGSLAGVFGAALGMLATALPWRAEIAPVTPPGVGSWSAAMLERGRQVAAAGDCAVCHTVSGGKANAGGLAMDTPFGTLYSTNITPDPETGIGRWSFAAFERAMREGISRDGRHLYPAFPYTSFRNINDADMQALYAYLMSQTPVRQEAPANQMRFPFNQRPLMAGWNARFLQRGEYQPDPQRSAQWNRGAYLVDGLGHCTACHSPRNLMGAEKGGSSYLAGGMVDGWEAPALNALGKSSTPWSEDELFNYLSTGFSEKHGVAAGPMGPVVSELATLPKSDVRAIAHYLSSLEGEPQALAANAAPQVDTHVSLSNGERVFKGACLGCHSDGLGPKLFGVSPSMAVNSNVHSDLPDNLLRVVLHGIPTPATRDLGYMPGFKDSLSDRQVADLAAYLRHRFAADKPAWQGLASKAAQVRANPGSH
Protein: Synaptophysin-like protein 1 (Pantophysin) (O09117)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:8707851}; Multi-pass membrane protein {ECO:0000269|PubMed:8707851}. Melanosome {ECO:0000250}. Note=Cytoplasmic transport vesicles.
Interaction partners:
Sequence:
MASKANMVRQRFSRLSQRMSAFQINLNPLKEPLGFIKILEWFASIFAFATCGGFKGKTEIQVNCPKVGVNKNQTVTATFGYPFRLNQASFHTPPNVSVCDVNWEKHVLIGDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTNLYRDSRKLPMIDFIVTLVATFLWLVSSSAWAKALTDIKVATGHRIVEELEICNPESGVSCYFVSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKETSLHSPSNTSASHSQGGGPPTSGM
Protein: Hexokinase-like 1 protein (EC 2.7.1.1) (Q9FZG4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Fructose and glucose phosphorylating enzyme.
Interaction partners:
- Glucose-6-phosphate isomerase, cytosolic
- Glucose-6-phosphate isomerase 1, chloroplastic
- Probable phosphoglucomutase, cytoplasmic 1
- Phosphoglucomutase, chloroplastic
- Probable phosphoglucomutase, cytoplasmic 2
- Phosphomannomutase
- Fructose-1,6-bisphosphatase, cytosolic
- Mannose-6-phosphate isomerase 2
- Mannose-6-phosphate isomerase 1
- Fructose-1,6-bisphosphatase 1, chloroplastic
Sequence:
MSLMFSSPVVTPALGSFTFSSRPRSNYIVMSAVRSNSASTCPILTKFQKDCATPTPYLRNVANAIADDMRDGLAVEGGGDLEMILTFVDALPSGNEEGLFYALDLGGTNFRVRSVQLGGKKERVLATESEQISISQKLMIGTSEELFGFIASKLANFVAKEKPGRFLLEEGRKRELGFTFSFPVKQTSIDSGTLSKWTKGFKVSGMEGKNVVACLNEAMEAHGLDMRVSALVNDGVGTLAGARYWDEDVMVGVILGTGTNACYVEQKHAIPKLRSKSSSGTTIINTEWGGFSKILPQTIFDLEMDETSLNPGEHLYEKMISGMYLGEIVRRVLLHMCETSDLFGHFAPAKLSTPLALRTEHLCKMQEDNTDDLRDVGSILYDFLDVEANMNARRRVVEVCDTVVKRGGRLAGAGIVAILEKIEKDTKRMGSGKRTVVAMDGALYEKYPQYRQYMQDALVELLGHKLASHVAIKHTKDVSGLGAALLAATNSIY