wanglab/gogpt-training-data huggingface dataset:
Protein: Protein phosphatase PP2A 55 kDa regulatory subunit (PR55) (Protein phosphatase PP2A regulatory subunit B) (Protein twins) (P36872)
Organism: Drosophila melanogaster (Fruit fly)
Function: Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment.
Interaction partners:
- Serine/threonine-protein phosphatase PP2A
- Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit
- Serine/threonine protein phosphatase 2A regulatory subunit
- Well-rounded, isoform B
- MIP22305p
- Serine/threonine-protein kinase polo
- separase
- Uncharacterized protein, isoform B
- Serine/threonine-protein kinase grp
- Endosulfine, isoform A
Sequence:
MGRWGRQSPVLEPPDPQMQTTPPPPTLPPRTFMRQSSITKIGNMLNTAININGAKKPASNGEASWCFSQIKGALDDDVTDADIISCVEFNHDGELLATGDKGGRVVIFQRDPASKAANPRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLQQKNPVHFLLSTNDKTVKLWKVSERDKSFGGYNTKEENGLIRDPQNVTALRVPSVKQIPLLVEASPRRTFANAHTYHINSISVNSDQETFLSADDLRINLWHLEVVNQSYNIVDIKPTNMEELTEVITAAEFHPTECNVFVYSSSKGTIRLCDMRSAALCDRHSKQFEEPENPTNRSFFSEIISSISDVKLSNSGRYMISRDYLSIKVWDLHMETKPIETYPVHEYLRAKLCSLYENDCIFDKFECCWNGKDSSIMTGSYNNFFRVFDRNSKKDVTLEASRDIIKPKTVLKPRKVCTGGKRKKDEISVDCLDFNKKILHTAWHPEENIIAVAATNNLFIFQDKF
Protein: Uncharacterized protein C56F8.12 (Q10260)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MMNDSQVQLFQLYNYSVYSNGTISNFTNCYLINDEHTPIIESDGMIYNGQSCDSPVKSLASHGAVGIVTACFCFFLIPLLLVNIAKYWKGKPPLLKRRMEFIWITLLILALAVGGFAYIDVDRNLVQGAAMKIFSFTFQTALPISIAIIWHVISTYGFALYRQRIVVGKHAAHFSLDHWIFVVEYYAPIVFYVFNLMGFFLAALHPWTKVVRGDGNAATDGRFKASSVLLAIAWVFACAMFIVYSFVYKLDRRGRWVGMVIMMISILPRIVYQFLETWSFTLNASNVSVNAGLVFGLGFCPPLILAYTVCIYGWAVPSIAELEKEAIHEECRQRKRRTTISRDNSTRSTWGIGSEHDMQCLPPSYETMGPCEKEMKEETNEVEIASIESGEVRE
Protein: Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344) (Q9ULV1)
Organism: Homo sapiens (Human)
Function: Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30135577}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
- Norrin
- Protein Wnt-5a
- Low-density lipoprotein receptor-related protein 6
- Tetraspanin-12
- Protein Wnt-11
- Protein Wnt-7a
- Protein Wnt-7b
- Segment polarity protein dishevelled homolog DVL-2
- Proto-oncogene Wnt-1
Sequence:
MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV
Protein: Small ribosomal subunit protein uS3m (28S ribosomal protein S24, mitochondrial) (MRP-S24) (S24mt) (Q9CQV5)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q2M2T7}.
Interaction partners:
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein mS33
- Small ribosomal subunit protein mS31
- Small ribosomal subunit protein mS34
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS5m
Sequence:
MAWSASVRGLGQRVLACSRELPGAWRTLHTSAVCAKNRAARVRVAKGNKPVSYEEAHAPHYIAHRKGWLSLHTGNLDGEDHAAERTLEDVFLRKFMMGTFPGCLADQIVLKRRANQVDICALVLRQLPAHKFYFLVGYSETLLSHFYKCPVRLHLQTVPSKVVYKYI
Protein: Acyl carrier protein, mitochondrial (ACP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) (P11943)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).
Subcellular location: Mitochondrion.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH-ubiquinone oxidoreductase 21 kDa subunit, mitochondrial
- NADH-ubiquinone oxidoreductase 14.8 kDa subunit
- NADH-ubiquinone oxidoreductase 12 kDa subunit, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH:ubiquinone oxidoreductase 10.6kD subunit
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial
- NADH-ubiquinone oxidoreductase 10.5 kDa subunit
- NADH dehydrogenase 1 alpha subcomplex subunit
Sequence:
MFRTAALTAARVARPAVASAVRAGVARPAFVQAVPKVAAFQAVRFYSAGGHLKKDEVFSRIAQVLSGFDKVNDPKNITETAHFANDLGLDSLDTVEVVMAIEEEFSIEIPDKDADQIHSVDKAVEYILSQPDAN
Protein: Alpha-terpineol synthase, chloroplastic (EC 4.2.3.111) (4-terpineol synthase) (EC 4.2.3.-) (Alpha-terpinolene synthase) (EC 4.2.3.113) (Beta-myrcene synthase) (EC 4.2.3.15) (Gamma-terpinene synthase) (EC 4.2.3.114) (Limonene synthase) (EC 4.2.3.16) (Terpene synthase 26, chloroplastic) (A0A1D6LTV0)
Organism: Zea mays (Maize)
Function: Component of the volatile terpenes biosynthesis pathways. Mediates the synthesis of a blend of monoterpenes. Converts mainly geranyl diphosphate to alpha-terpineol. Triggers also the biosynthesis of minor monoterpenes including limonene, gamma-terpinene, beta-myrcene, terpinolene and 4-terpineol.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18218975}.
Interaction partners:
Sequence:
MAGITGVMNMKLAARPSSGRHSRGCRPAVVPSAGKQMLLVRRHPPGSASWPTRATGGGGGGVPAGATAADSSGQAKEEEEEDRASRNTSSFEPSIWGDFFLTYSSPLATSSAQKARMVHRAEQLKKQVAKLIAASGACSLYHRIHLVDALERLCLDYLFEDEINDMVTQIHNVDVSGCDLQTVAMWFYLLRNHGYRVSSDVVFAKFRDEQGGFAANNPRDLLNLYNAACLRTHGETILDEAASFTSKCLKSLAPYTYMEASLASEIKRALEIPLPRSVRIYGAKSRIAEYGNQTEANELVLELAKLNYNLVQLQHQEELKIITRWWNDLELQTRLSFARDRVVECYFWMVGVYFEPSYSRARVILSKVLAIVSLLDDTYDVYGTSQECELFTKCIESWDPAATGGRLPGNMKFIFAKILDTCQSFEDELAPDEKYRMHYLKTFIIDLVRAYNEEVKWREQGYVPATVEEHLQVSARSGGCHLLSCTSFVGMGDVADQEAFEWVRGVPKIVKALCIILRLSDDLKSYEREKMSSHVASTMESCMKEHQVPLEVARVKIQETIDETWKDFNEEWLNLNTNSHLPRELLERIFNLTRTMVYIYQQDDAYTNCHVIKDTINSLFVEPVSIT
Protein: [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (mMical1) (NEDD9-interacting protein with calponin homology and LIM domains) (Q8VDP3)
Organism: Mus musculus (Mouse)
Function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8TDZ2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8TDZ2}. Endosome membrane {ECO:0000250|UniProtKB:Q8TDZ2}. Midbody {ECO:0000250|UniProtKB:Q8TDZ2}.
Interaction partners:
- Enhancer of filamentation 1
- Plexin-A1
- Ras-related protein Rab-10
- Ras-related protein Rab-35
- AP-4 complex accessory subunit RUSC2
Sequence:
MASPASTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGSGWRAQLQPNPPAQLASYEFDVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDLENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFATHGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDMMDKEHAQRKSDEPDSRKTTTGSAGTEELLHWCQEQTAGFPGVHVTDFSSSWADGLALCALVHHLQPGLLEPSELQGMGALEATTWALRVAEHELGITPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNTSHSSGLVSQPSGTPSAILFLGKLQRSLQRTRAKVDEETPSTEEPPVSEPSMSPNTPELSEHQEAGAEELCELCGKHLYILERFCVDGHFFHRSCFCCHTCEATLWPGGYGQHPGDGHFYCLQHLPQEDQKEADNNGSLESQELPTPGDSNMQPDPSSPPVTRVSPVPSPSQPARRLIRLSSLERLRLSSLNIIPDSGAEPPPKPPRSCSDLARESLKSSFVGWGVPVQAPQVPEAIEKGDDEEEEEEEEEEEEEPLPPLEPELEQTLLTLAKNPGAMTKYPTWRRTLMRRAKEEEMKRFCKAQAIQRRLNEIEATMRELEAEGTKLELALRKESSSPEQQKKLWLDQLLRLIQKKNSLVTEEAELMITVQELDLEEKQRQLDHELRGYMNREETMKTEADLQSENQVLRKLLEVVNQRDALIQFQEERRLREMPA
Protein: Haptoglobin (Liver regeneration-related protein LRRG173) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] (P06866)
Organism: Rattus norvegicus (Rat)
Function: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Scavenger receptor cysteine-rich type 1 protein M130
- Hemopexin
- Globin c1
- Albumin
- Alpha-1-antiproteinase
- Alpha-1-acid glycoprotein
- Hemoglobin subunit beta-1
- Hemoglobin alpha, adult chain 2
- Hemoglobin subunit zeta
- Fibrinogen gamma chain
Sequence:
MRALGAVVTLLLWGQLFAVELGNDATDIEDDSCPKPPEIANGYVEHLVRYRCRQFYKLQTEGDGIYTLNSEKQWVNPAAGDKLPKCEAVCGKPKHPVDQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAQNLFLNHSENATAKDIAPTLTLYVGKNQLVEIEKVVLHPERSVVDIGLIKLKQKVLVTEKVMPICLPSKDYVAPGRMGYVSGWGRNVNFRFTERLKYVMLPVADQEKCELHYEKSTVPEKKGAVSPVGVQPILNKHTFCAGLTKYEEDTCYGDAGSAFAVHDTEEDTWYAAGILSFDKSCAVAEYGVYVRATDLKDWVQETMAKN
Protein: Guided entry of tail-anchored proteins factor 1 (Congenital heart disease 5 protein) (Tail-anchored protein insertion receptor WRB) (Tryptophan-rich basic protein) (O00258)
Organism: Homo sapiens (Human)
Function: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21444755}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Guided entry of tail-anchored proteins factor CAMLG
- ATPase GET3
- Golgi to ER traffic protein 4 homolog
- Ubiquitin-like protein 4A
- Small glutamine-rich tetratricopeptide repeat-containing protein alpha
- ER membrane protein complex subunit 3
- Non-histone chromosomal protein HMG-14
- Mitochondrial inner membrane protein OXA1L
- Syntaxin-5
- Stress-associated endoplasmic reticulum protein 1
Sequence:
MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS
Protein: Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) (Q9NQU5)
Organism: Homo sapiens (Human)
Function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
Subcellular location: Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Interaction partners:
- Cell division control protein 42 homolog
- Androgen receptor
- Rho guanine nucleotide exchange factor 7
- SH2/SH3 adapter protein NCK1
- Ras-related C3 botulinum toxin substrate 2
- LIM domain kinase 1
- Serine/threonine-protein kinase PAK 4
- Rho guanine nucleotide exchange factor 6
- Ras-related C3 botulinum toxin substrate 3
- Ras-related C3 botulinum toxin substrate 1
Sequence:
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
Protein: Glra4b protein (Q5U3C8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
DGSGGETRVHQNGRPAPQKHICSLRFSHGTPEKQLLNSERMFSVIWRILLELLLVCWMFEGVIRCVFSKELKSPSVRTKPMSPSDFLDKLMGKTSGYDARIRPNFKGPPVNVTCNIFINSFGSITETTMDYRLNVFLRQQWNDPRLAYKEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFQNGNVLYSIRLTLILSCPMDLKNFPMDTQTCTMQLESFGYTMNDLIFQWLDEGPVQVADDLMLPQFVLKEEKDLGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLTVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQYKEFFRLRRKLRQEQRNRAASGQAGAAETKNKSNNVTGGTPSRNAQRQCSACAREEQLASQNQDLYFPGFGIDTSLSGDGPLSEAAAMFAGLPPGHALFDIRRRFVEQAKRIDTISRAVFPLSFLVFNVFYWVTYKVLRNEDIHLALRP
Protein: O-fucosyltransferase 15 (O-FucT-15) (EC 2.4.1.-) (O-fucosyltransferase family protein) (F4HYR4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
- O-fucosyltransferase 36
- BAG family molecular chaperone regulator 8, chloroplastic
- Trimethylguanosine synthase
- O-fucosyltransferase 23
- WAT1-related protein At1g44800
- Probable xyloglucan galactosyltransferase GT11
- Protein BPS1, chloroplastic
- AT5g42660/MJB21_3
- Transmembrane protein
Sequence:
MSSERPDEEKPETRDVLRVQDLIHGGGGASPVQSPTRLGPTRFSEVAGDKILNTGSNCIGSVLSWINGDPNRNLKNPVKRAKRKRIRTAKTAAFVIVLVGFFIFVNWFMLSQLHEGRAWLRRGFSKKTNLKPKLNPDPNSSVKRVSVKVSANVQHKEKKKMGKPKKTYNGTYGRLLAYAAHALAEGQNKLEPKELWREPKDQALAWKPCADQRSWKPSDGKNGYIMVTANGGINQQRVAVCNIVVVARMLNATLVIPKFMFSDVWTDASQFGDIYQVEHFIKYLSPDIRIVKKLPKELQSLDLEAIGSVVTDIDVMKEAKPGFYMKHILPLLLKNRVVHFLGFGNRLAFDPIPFELQRLRCRCNFHALNFVPKIQETGAILVRRLRDSGSHLAPVDPYLVGPKFASFILDKKAGPLHKASKYLAVHLRFEIDMVAHSLCYFGGGDAEKAELDAYREKHFPTLANLTKTQKMPSPDDLRTEGLCPLSPEEAVLMLAGLGFSRKTRVFVAGANIYGGNKRLAALTSLYPNLVTKENVLSQTELEPFKNFSSQLAVLDFIACAASDAFAMTDSGSQLSSLVSGYRIYYGAGKMPTIRPNKRRFSDILLKNNTIEWKVFEQRVRKTVRQTKHVLVRPTGRSVYRYPRCKECMCNED
Protein: PDZ and LIM domain protein 7 (R4GKC8)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MGEMESYKVMLNGPAPWGFRLQGGKDFSMPLSISRLTPGGKAAQAGVGVGDWVLYIDGESTGTMTHIEAQNRIRACGDRLCLTLSRAQNHLGKPQKDSLPCSEPPKYNFAPSTALNKTARPFGASSPPNPRPGLVTKPVTYVPLAPACTPQHNGQVSVPDPSPGAAMKTEPGLAPRTPAATPGPTSRPPWAVDPSFAERYAPDKTSTVLSKHSQPATPTPMQNRSSIVQAAQQAPEGPGRTPLCYKCNKIIRGRYLVALGHYYHPEEFTCCQCRKVLDEGGFFEEKGSIFCPKCYDTRYAPSCAKCKKKITGEVMHALKMTWHVQCFTCAACKTPIRNRAFYMEEGQPYCERDYEKMFGTKCRGCDFKIDAGDRFLEALGFSWHDTCFVCAICQTNLEGKTFYSKKDKPLCKSHAFSHV
Protein: Cytochrome P450 85A2 (AtCYP85A2) (EC 1.14.14.180) (28-norcastasterone synthase) (EC 1.14.14.-) (28-nordeoxoteasterone synthase) (EC 1.14.14.-) (28-norteasterone synthase) (EC 1.14.14.-) (28-nortyphasterol synthase) (EC 1.14.14.-) (3-dehydroteasterone synthase) (EC 1.14.14.179) (Brassinolide synthase) (EC 1.14.14.180) (Brassinosteroid-6-oxidase 2) (BR6ox 2) (C6-oxidase 2) (Castasterone synthase) (EC 1.14.14.179) (Teasterone synthase) (EC 1.14.14.179) (Typhasterol synthase) (EC 1.14.14.179) (Q940V4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the C6-oxidation step and lactonization in brassinosteroids biosynthesis. Converts 6-deoxocastasterone (6-deoxoCS) to castasterone (CS), and castasterone to brassinolide (BL). May also convert 6-deoxoteasterone (6-deoxoTE) to teasterone (TE), 3-dehydro-6-deoxoteasterone (6-deoxo3DT, 6-deoxo-3-DHT) to 3-dehydroteasterone (3DT, 3-DHT), and 6-deoxotyphasterol (6-deoxoTY) to typhasterol (TY). Seems also able to convert teasterone (TE) and typhasterol (TY) to 7-oxateasterone (7-OXTE) and 7-oxatyphasterol (7-OXTY), respectively. Catalyzes the conversion of 6-deoxo-28-norteasterone (6-deoxo-28-norTE) to 28-norteasterone (28-norTE), 6-deoxo-28-nordeoxoteasterone (6-deoxo-28-nor-3-DHT) to 28-nordeoxoteasterone (28-nor-3-DHT), 6-deoxo-28-nortyphasterol (6-deoxo-28-norTY) to 28-nortyphasterol (28-norTY) and 6-deoxo-28-norcastasterone (6-deoxo-28-norCS) to 28-norcastasterone (28-norCS). Involved in a negative regulation of responses to abscisic acid (ABA) and drought tolerance.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:27455172}. Note=Concentrates in endoplasmic reticulum subdomains adjacent to chloroplasts when farnesylated. {ECO:0000269|PubMed:27455172}.
Interaction partners:
- Cytochrome P450 734A1
- 3-epi-6-deoxocathasterone 23-monooxygenase CYP90C1
- 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1
- Cytochrome P450 85A1
- Steroid 5-alpha-reductase DET2
- Cytochrome P450 72C1
- Delta
- 7-dehydrocholesterol reductase
- Delta
- Protein BRASSINOSTEROID INSENSITIVE 1
Sequence:
MGIMMMILGLLVIIVCLCTALLRWNQMRYSKKGLPPGTMGWPIFGETTEFLKQGPDFMKNQRLRYGSFFKSHILGCPTIVSMDAELNRYILMNESKGLVAGYPQSMLDILGTCNIAAVHGPSHRLMRGSLLSLISPTMMKDHLLPKIDDFMRNYLCGWDDLETVDIQEKTKHMAFLSSLLQIAETLKKPEVEEYRTEFFKLVVGTLSVPIDIPGTNYRSGVQARNNIDRLLTELMQERKESGETFTDMLGYLMKKEDNRYLLTDKEIRDQVVTILYSGYETVSTTSMMALKYLHDHPKALEELRREHLAIRERKRPDEPLTLDDIKSMKFTRAVIFETSRLATIVNGVLRKTTHDLELNGYLIPKGWRIYVYTREINYDTSLYEDPMIFNPWRWMEKSLESKSYFLLFGGGVRLCPGKELGISEVSSFLHYFVTKYRWEENGEDKLMVFPRVSAPKGYHLKCSPY
Protein: Hydrogenase-4 component B (EC 1.-.-.-) (P23482)
Organism: Escherichia coli (strain K12)
Function: Possible component of hydrogenase 4.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Hydrogenase-4 component G
- Hydrogenase-4 component E
- Hydrogenase-4 component D
- Hydrogenase-4 component C
- Hydrogenase-4 component F
- Hydrogenase-4 component I
- Formate hydrogenlyase subunit 5
- Formate hydrogenlyase subunit 4
- Formate hydrogenlyase subunit 7
- Formate hydrogenlyase subunit 6
Sequence:
MDALQLLTWSLILYLFASLASLFLLGLDRLAIKLSGITSLVGGVIGIISGITQLHAGVTLVARFAPPFEFADLTLRMDSLSAFMVLVISLLVVVCSLYSLTYMREYEGKGAAAMGFFMNIFIASMVALLVMDNAFWFIVLFEMMSLSSWFLVIARQDKTSINAGMLYFFIAHAGSVLIMIAFLLMGRESGSLDFASFRTLSLSPGLASAVFLLAFFGFGAKAGMMPLHSWLPRAHPAAPSHASALMSGVMVKIGIFGILKVAMDLLAQTGLPLWWGILVMAIGAISALLGVLYALAEQDIKRLLAWSTVENVGIILLAVGVAMVGLSLHDPLLTVVGLLGALFHLLNHALFKGLLFLGAGAIISRLHTHDMEKMGALAKRMPWTAAACLIGCLAISAIPPLNGFISEWYTWQSLFSLSRVEAVALQLAGPIAMVMLAVTGGLAVMCFVKMYGITFCGAPRSTHAEEAQEVPNTMIVAMLLLAALCVLIALSASWLAPKIMHIAHAFTNTPPATVASGIALVPGTFHTQVTPSLLLLLLLAMPLLPGLYWLWCRSRRAAFRRTGDAWACGYGWENAMAPSGNGVMQPLRVVFSALFRLRQQLDPTLRLNKGLAHVTARAQSTEPFWDERVIRPIVSATQRLAKEIQHLQSGDFRLYCLYVVAALVVLLIAIAV
Protein: Proteasome subunit alpha type-1 (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein) (P21243)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Proteasome subunit alpha type-6
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit RPN2
- 26S proteasome regulatory subunit 6A
- Proteasome subunit beta type-7
- Probable proteasome subunit alpha type-7
- Proteasome subunit beta type-3
- Proteasome subunit alpha type-5
- 26S proteasome regulatory subunit 4 homolog
- Proteasome subunit beta type-5
Sequence:
MSGAAAASAAGYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHMIDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQD
Protein: Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) (Q9HVB9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Cyanate hydratase
- Carbonic anhydrase
- Carbonic anhydrase
- Probable sulfate transporter
- Serine/threonine transporter SstT
Sequence:
MSDLQQLFENNVRWAEAIKQEDPDFFAKLARQQTPEYLWIGCSDARVPANEIVGMLPGDLFVHRNVANVVLHTDLNCLSVIQFAVDVLKVKHILVTGHYGCGGVRASLHNDQLGLIDGWLRSIRDLAYEYREHLEQLPTEEERVDRLCELNVIQQVANVSHTSIVQNAWHRGQSLSVHGCIYGIKDGLWKNLNVTVSGLDQLPPQYRLSPLGGCC
Protein: Uncharacterized protein (Q584Q9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFRLDGCLMGRWSHRDFLRGRTKLGGSVHTRHTHGSRGRYKRLSSMYGLRDGRRHAWNHMHGGLGLKAGGGLFGLRIPRQHALSTLSKEEYDIALHGHPNITNPYRLYMDEHPDLESVMRNACLKVQLVLLMPRVRRTALQTNSLPPSWEGLLRHVGEALQGEMKFLGQSRGVTTHFTTMSASATCSCSASDALRAAAVSLFEDHVRGTKLKVQGSNLLRRDAKGRCSRFFGSALSNPCIPLSLSAPALKATALPSSTPPQLRSGIGAAKTEVAPSVFKLSEYHMDSTTPTKNSDTAATTVTTKSAYHLTQRGAQQLLLDLRHDNPGALCMCLRLGEIIHNGEDLHECVGQQNGGEPKRKLLREDLDPDEVGVWKHPATSVDALMRWQYLNWDPRGHCADVLPHDKRVQTVCIFVDASRARCYGELPSTDTSDGAQQRVSRSLMTEQFSEKLLEMDYKCVESNDLVGALAGLKRWSVDYQWRAVDSRMRAAC