wanglab/gogpt-training-data huggingface dataset:
Protein: Peptidase C15, pyroglutamyl peptidase I-like protein (Q9C5G6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGSEGPKAITIHVTGFKKFLGVSENPTEKIANGLKSYVEKRGLPSGLCLGSCSVLDTAGEGAKSKLYEVLESSVVSGDKNNNGTVVWLHLGVNSGATKFAIERQAVNEAHFRCPDELGWQPQRLPIVVEDGGISKAKETSCSTESIFQLLKKKGFEVVQSDDAGRFVCNYVYYHSLRFAEQKGHKSLFVHVPLFSKIDEDTQMQFVASLLEAIAATC
Protein: Membrane spanning 4-domains A1 (D4A4Y3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- CD19 molecule
- B-cell receptor CD22
- B-cell antigen receptor complex-associated protein beta chain
- CD79a molecule
- Cd79a molecule-like.
- POU class 2 homeobox associating factor 1
- Complement C3d receptor 2.
- Marginal zone B- and B1-cell-specific protein
- Fc receptor-like A
- Receptor-type tyrosine-protein phosphatase C
Sequence:
MTTPRNSVSGPFPTEPTKGPLAMQPAQKVIPRRPSSLVGPTQSFFMRESKALGAVQIMNGLFHISLGGLLMIPTGVFAPICLSVWYPLWGGIMYIISGSLLAAAAEKTSRKSLVKAKVIMSSLSLFAAISGIILSIMDILNITVSHFLKMERLELIKTPKLYVDIYNCEPSNSSEKNSPSTQYCNSVQSVFLGILSVMLISAFFQKLVTAGVVENEWKRVCSRPKSNVVLLSAGEKKEQTIKMKEEIIELSGVSSQPKNEEEIEIIPVQEEEEEEAEINFPAPPQEQESLPVENEISP
Protein: D-tagatose-1,6-bisphosphate aldolase subunit GatZ (P0C8J8)
Organism: Escherichia coli (strain K12)
Function: Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol.
Interaction partners:
- PTS system galactitol-specific EIIA component
- PTS system galactitol-specific EIIB component
- D-tagatose-1,6-bisphosphate aldolase subunit GatY
- Galactitol 1-phosphate 5-dehydrogenase
- D-tagatose-1,6-bisphosphate aldolase subunit KbaY
- D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
- ATP-dependent 6-phosphofructokinase isozyme 2
- 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
- ATP-dependent 6-phosphofructokinase isozyme 1
- Putative D-galactosamine-6-phosphate deaminase AgaS
Sequence:
MKTLIARHKAGEHIGICSVCSAHPLVIEAALAFDRNSTRKVLIEATSNQVNQFGGYTGMTPADFREFVFTIADKVGFARERIILGGDHLGPNCWQQENADAAMEKSVELVKEYVRAGFSKIHLDASMSCAGDPIPLAPETVAERAAVLCFAAESVATDCQREQLSYVIGTEVPVPGGEASAIQSVHITHVEDAANTLRTHQKAFIARGLTEALTRVIAIVVQPGVEFDHSNIIHYQPQEAQPLAQWIENTRMVYEAHSTDYQTRTAYWELVRDHFAILKVGPALTFALREAIFALAQIEQELIAPENRSGCLAVIEEVMLDEPQYWKKYYRTGFNDSLLDIRYSLSDRIRYYWPHSRIKNSVETMMVNLEGVDIPLGMISQYLPKQFERIQSGELSAIPHQLIMDKIYDVLRAYRYGCAE
Protein: Serpin, putative (Q9U5W8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAVIISCLLLLLATVSQSKTVGYDAAADRNLLAADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDADAVSQRSGSYQQALTRDNNFRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQNAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEVNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSLSGKNLLAEIGALSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNMYRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSKKFEADHPFVFAIKYKDSIAFIGHIANYAYV
Protein: Transcription factor SOX-18 (P35713)
Organism: Homo sapiens (Human)
Function: Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- Claudin-5
- Prospero homeobox protein 1
- Forkhead box protein C2
- Vascular endothelial growth factor receptor 3
- COUP transcription factor 2
- Roundabout homolog 4
- Recombining binding protein suppressor of hairless
- Vascular endothelial growth factor receptor 2
- Matrilysin
Sequence:
MQRSPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDCALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSPPPEAPPLESAEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCPEESSLISALSDASSAVYYSACISG
Protein: Uncharacterized protein, isoform C (A0A0B4KEC2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIKNEQRPLNFEKCPESDDELKKRLEIEKLINKNIDKNISFDVLVKLSLAPYGLVNDDFRRILWPQLAGVDINHLGQAPTLDKFQCHPEYNQVVLDVNRSLKRFPPGIPYEQRIALQDQLTVLILRVIQKYPNLRYYQGYHDVAVTFLLVVGEEIAFAIMEQLSTTHFSECMQETMEATQRRLMFIWPIIKFENPELYQFLQNSTVGTLFSLPWYLTWFGHSLTSYRTVVRLYDYFLASPIYTSIFVTAAILLYRSDEILKEDCDMASVHCLLSIPEDLPFEDLLKTSSSLLNKYSLTLIEKDVEELICQERKRKTDEALIVKRRQPATSNRIPIITKWLPNILTAKPVILTTAISIVVGVCAYYYNNQYLAAGIS
Protein: Kinetoplastid kinetochore protein 14 (Q38AN9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEEVNAYSPYKAYYGFDRTYIRRMSLLDYMKEDEDATSVEGLRCQTDDAKRRNGLLTSRDPNVVFRSQFPVRDNCGRELCVLYQIIESEVQHELLRVEGRGDATRNSAVRLASGTGVSNERNHASVTRPVGHVEEQDHEGRDSVYRPTPYVNLPPMNDTESNFEVSASTQRFSSLVAPSESYTLTPAAAAAGTVPMSQFSTYPDRRANPCVNPFPWSEGVVGQPRQQPRDQLLFQSEVISDGRHSAFPVLLSTGEDLGQSSENQTSQLASAAPPLRSSTASPLEWQGAVNDRLGGEGVTSSSSVLHAKTSPECPADGSASQRAGEGLSEFRTTKQLFPPKCGPTPQSTVHHPVTIPTKVYGAQSQTIPAASVLSFVNANVEAFCSGGEFYTSDASAPQVSPGKVLVLEGRFYRIVCHHASADVYEAQEMTEGPTQGVPSVIPSCSSAMGSPPQALIYRWSVRAVQEGVNEAHRAALGLSYVTGSTSAVHVAGYRYSDGGLTVITLAKGYRSVPLSLLPLSPCSFPTCMKLILKMLLDLVARRTVHGNLYGLNHIFFALPDGGGAQDMTSALLIPVHWEKLVDFSMFVDRNAGRTIPLTYGESCHRGECVFHGHDVATLMRALLENENAIHLHQQQVEKIRSLVSGVAEGMQVAAYLVQLNTAMLAIPGDAVALINEYNAALRFPR
Protein: Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) (Q7M753)
Organism: Mus musculus (Mouse)
Function: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:23152917}.
Interaction partners:
Sequence:
MGGWLGRQRRLLRMGAGRFGAPMERQGRAAATSAAVGESADSEARRRDPLRRRASSAAPSGSGEAESVRRERPGSLGGSTSAGRPRAEGLRKRRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEKEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRFPTHDMPAFIQMGRDKNFSSLHTVFCATGGGSYKFEQDFLTIGDLQLRKLDELDCLIKGILYIDSVGFNGRSQCYYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFGLCCLLTGCSTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAASKEDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRVNTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLELLKIP
Protein: ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) (O51669)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01981}.
Interaction partners:
- Glucose-6-phosphate isomerase
- Pyruvate kinase
- Fructose-bisphosphate aldolase
- Enolase
- Triosephosphate isomerase
- 1-phosphofructokinase
- mannose-6-phosphate isomerase
- DNA polymerase I
- Phosphoglycerate kinase
- Glyceraldehyde-3-phosphate dehydrogenase
Sequence:
MYRIKNENLDFKIDSLGECKQNNPLIDFYASEGSSHFVNEKNKIKFSVYRNEDKGDRYEDVLLEKAGPREKIYFVPRHVKAAITTCGGLCPGFNDVIRSIVRTLWKIYGVRNIYGVKFGYQGLLPESNSPFINLNPDVVDDINKFGGTILGSSRGGIKPVEIVDTLERMNINMIFNIGGDGTQKGSLLIAEEIEKRNLKIAVVGIPKTVDNDFMFVQKSFGFETAVEQAVAAVAGAHFEANSAYNGIGLVKVMGRDSGFIAAHTALSSNDVNFCLIPELDFDIEGPNGFLVHLERRLLEKESLEEIPHAVILIAEGAGQKYFDHFPKKKDDSGNLLYEDIGLYIKDKITEYFKAKNIQFTLKYIDPSYIIRSSPANASDSLYCARLGSNAVHAAMAGKTKMLISLWSTKFVHIPIKMAVIDRNKVNPNGSFWRDVLSSTGQPISMKN
Protein: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3 (EC 2.7.11.1) (Lethal protein 37) (Myt1 kinase) (O18209)
Organism: Caenorhabditis elegans
Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation. Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:16466390}.
Interaction partners:
- G2/mitotic-specific cyclin-B
- Cyclin N-terminal domain-containing protein
- M-phase inducer phosphatase cdc-25.2
- M-phase inducer phosphatase cdc-25.1
- Serine/threonine-protein kinase plk-2
- G2/mitotic-specific cyclin-B1
- Tyrosine-protein phosphatase cdc-14
- M-phase inducer phosphatase cdc-25.3
- Cyclin-dependent kinase 1
- Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
Sequence:
MDDTEGNSSMDSIRNGQSSPLPQVTPRLPQIPMMMRETPLSTKRERQAITPRFRRPAPKMIKTMPPTRSIWSVRKESVPLLVTPQGPKPLESPKYDHTNAQSFFEQVFQIDEIIGRGSFGEVFAARCREDSQLYAVKVSLAPIRQHSISKYREAESHMIIPPHKNLVKFYRAWEETGRLYIQTELCDQSLLKYCTEKHALPEDEIWNIFVDLLQAVHHLHSNDMIHDDIKPENIFLTKDMICKLGDFGLVINLKNPNDVKSAEEGDSKYLAPEVLNGRPTKSSDIFSLGMTILEATTDLDVPSNGDSWHQIRNGQIPDRFFAGISTDLRSLIALMLDSDPRIRPTSRDLLDHPVIKKKLMKRGTYVKCISILNGFFYAFSAVLVWVMAFFSVLFHPIVRFHAAIKDRQSEICAQFVNNQQHTPIQTPETSKVYLESLTGVAVRQASQIVSPFDFSDDENPPNAQRRLFTGAVPCRLNFDNDQDDDEEQATCSSSNSSAIEPQLDEPESPPRMNDVIDKLGKRGTPRSARRNLTFNRHRQVAASVAPKSSLNHYNHHTGSGDGFSNNSLIPISDQERTEKYLRMRLTEQQLDWADQNNVIDEAPPPMSCPPRIRRSIRDLPRMPVLNFNVLDEPSNKPTVDHHTILEQSESPRRRLNRGAKPVPRNRMMSFGSSGDEV
Protein: Myotrophin (Granule cell differentiation protein) (Protein V-1) (P62775)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
Interaction partners:
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha-1
- F-actin-capping protein subunit alpha-2
- F-actin-capping protein subunit alpha
- F-actin-capping protein subunit alpha-3
- Alpha-adducin
- Beta-adducin
- Capping protein regulator and myosin 1 linker 2
Sequence:
MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTALEATDNQAIKALLQ
Protein: Nucleoporin NUP42 (Nucleoporin-like protein 2) (B4DT96)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus membrane {ECO:0000256|ARBA:ARBA00004335}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004335}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004335}. Nucleus, nuclear pore complex {ECO:0000256|ARBA:ARBA00004567}.
Interaction partners:
Sequence:
MAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQPQQQPSGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWESSGQWMFSVYSPVKKKPNISVPKPFLG
Protein: Inhibitor of nuclear factor kappa-B kinase subunit alpha (EC 2.7.11.10) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (G3V926)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- NF-kappa-B essential modulator
- NF-kappa-B inhibitor alpha
- Nuclear factor NF-kappa-B p105 subunit
- Transcription factor p65
- TNF receptor-associated factor 6
- NF-kappa-B inhibitor beta
- Interleukin-1 receptor-associated kinase 1
- Protein NLRC5
- TNF receptor-associated factor
Sequence:
MERPPGLRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMTGEVRFSSHLPQPNNLCSLIVEPMESWLQLMLNWDPQQRGGPIDPPLKQPKCFVLMDNILNLKIVHILNMTSAKIISFLLPYDESLHSLQSRIERETGINTGSQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPVTQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKLEFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYSEVGVIGYLEDQIMSLHTEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPTDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACRDVSTNDRRKSELSWPFKYYYS
Protein: Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) (P49446)
Organism: Mus musculus (Mouse)
Function: Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver (By similarity). Plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin can induce translocation to the membrane.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Interaction partners:
- 6-pyruvoyl tetrahydrobiopterin synthase
- WD repeat-containing protein 5
Sequence:
MEPFCPLLLASFSLSLARAGQGNDTTPTESNWTSTTAGPPDPGASQPLLTWLLLPLLLLLFLLAAYFFRFRKQRKAVVSSNDKKMPNGILEEQEQQRVMLLSRSPSGPKKFFPIPVEHLEEEIRVRSADDCKRFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHCRVILSQVDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQRSATIVMLTNLKERKEEKCYQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIHPQLPDSCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPSHAGPIVVHCSAGVGRTGTFIVIDAMMDMIHSEQKVDVFEFVSRIRNQRPQMVQTDVQYTFIYQALLEYYLYGDTELDVSSLERHLQTLHSTATHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEFTDYINASFIDGYRQKDYFMATQGPLAHTVEDFWRMVWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGDITIEIKSDTLSEAISVRDFLVTFKQPLARQEEQVRMVRQFHFHGWPEVGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
Protein: Small ribosomal subunit protein uS14 (40S ribosomal protein S29) (Q9VH69)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62273}. Cytoplasm {ECO:0000305|PubMed:23636399}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6QAP6}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P62273, ECO:0000250|UniProtKB:Q6QAP6}.
Interaction partners:
- 60S ribosomal protein L27
- 40S ribosomal protein S27
- Small ribosomal subunit protein eS10A
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein uL6
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein uL29
Sequence:
MGFATLWYSHPRKYGQGSRCCRACSNRHGLIRKYGLNICRQCFREYANDIGFKKLD
Protein: Viral desmoplakin N-terminal domain-containing protein (Q8B9I6)
Organism: Rachiplusia ou multiple nucleopolyhedrovirus (strain R1) (RoMNPV)
Interaction partners:
Sequence:
MQRWPKYGGTDVNTRTVHDLLNTINTMSARIKTLERYEHALREIHKVVVILKPSANTHSFEPDALPALIMQFLSDFAGRDINTLTHNINYKYDYNYPQPPAPVPAMQPPPPPPQPPAPPQPPYYGNYPYYPPYPFSTPPQQPPESNVAGVGGSQSLNQITLTNEEESELAALLKNMQTNMTWELVQNFVEVLIRIVRVHVVNNVTMINVISSITSVRTLIDYNFTEFIRCVYQKTNIRFAIDQYLCTNIVTFIDFFTRVFYLVTRTNFQFTTFDQLTLYSNELYTKIQTSILQSTAPLSPPTVETVNSDIVISNLQEQLKRERALMQQIAEQHKIANEKVEALQAQYNDLDLKYKDIFEDKSEFAQQKSENVRKIKQLEKSNKELNDTVQELRDENAERLSEIQLQKGDLDEYKNMNRQLNEDIYKLKRRLESTFDKDYVETLKDKIESLEKQLDDKQNLNRELKSNISKIDETTQRYKLDAKDIMELKQSVSIKDQEIAMKNAQYLELNNAHQQTVNELIATKNELSQVATANQSLFAENEESKVLLEGTLAFIDSFYQIIMQIEKPDYVPISKPQLTAQESIYQTDYIKDWLQKLRSKLSNVDVANLQSISELNDLKSQIISIVPRNIVNRILKENYRVKVENINAELLENVAVTSAVSALVQQYERSEKQKVTLRQEFEIKLNDLQRLLEQNQTDFESISEFISRDPAFNRNLNDERFQNLRQQYDEMSSKYSALETTKIKEMENIADQAVKLEMSKLNTQLDELNSLFVKYNRKAQDIFEWKTSMLKRYETLARTTAASGVQPNIE
Protein: Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4) (Q8VE97)
Organism: Mus musculus (Mouse)
Function: Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 (By similarity).
Subcellular location: Nucleus speckle {ECO:0000250}.
Interaction partners:
- SRSF protein kinase 1
- Serine/arginine-rich splicing factor 10
- Nuclear RNA export factor 1
- RNA-binding protein 25
- Transformer-2 protein homolog beta
- Nuclear RNA export factor 7
- Tip-associated protein
- Tip-associated protein
- Splicing factor U2AF 65 kDa subunit
- SRSF protein kinase 2
Sequence:
MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDLCGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSHSRSKSRSRSQSRSRSKKEKSRSPSKDNKSRSRSRSPDKSRSKSKDHAEDKLQNNDSAGKAKSHSPSRHDSKSRSRSQERRAEEERRRSVSRARSQEKSRSQEKSLLKSRSRSRSRSRSRSKDKRKGRKRSRDESRSRSRSKSERSRKHSSKRDSKVSSSSSSSKKKKDTDHSRSPSRSVSKEREHAKAESGQRGSRAEGESEAPNPEPRARSRSTSKSKPNVPAESRSRSKSASKTRSRSKSPSRSASRSPSRSRSRSHSRS
Protein: Uncharacterized protein Rv1339 (P9WGC1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Ribonuclease PH
- Cytochrome bc1 complex cytochrome b subunit
- O-phosphoserine sulfhydrylase
- Sulfur carrier protein CysO
- CysO-cysteine peptidase
- dITP/XTP pyrophosphatase
- Uncharacterized aminopeptidase Rv1333
- Oxidative stress regulator AosR
- ATP-dependent Clp protease adapter protein ClpS
- Glutamate racemase
Sequence:
MRRCIPHRCIGHGTVVSVRITVLGCSGSVVGPDSPASGYLLRAPHTPPLVIDFGGGVLGALQRHADPASVHVLLSHLHADHCLDLPGLFVWRRYHPSRPSGKALLYGPSDTWSRLGAASSPYGGEIDDCSDIFDVHHWADSEPVTLGALTIVPRLVAHPTESFGLRITDPSGASLAYSGDTGICDQLVELARGVDVFLCEASWTHSPKHPPDLHLSGTEAGMVAAQAGVRELLLTHIPPWTSREDVISEAKAEFDGPVHAVVCDETFEVRRAG
Protein: Ribosomal RNA small subunit methyltransferase H (EC 2.1.1.199) (16S rRNA m(4)C1402 methyltransferase) (rRNA (cytosine-N(4)-)-methyltransferase RsmH) (P9WJP1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01007}.
Interaction partners:
- Transcriptional regulator MraZ
- Ribosomal RNA small subunit methyltransferase I
- Penicillin-binding protein PbpB
- Probable conserved proline rich membrane protein
- Ribosomal RNA small subunit methyltransferase E
- tRNA
- Probable dual-specificity RNA methyltransferase RlmN
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein bS16
- protein adenylyltransferase
Sequence:
MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVRRRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS
Protein: Fork head domain-containing protein L1 (Q02360)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription factor (By similarity). Coordinates the placement and migration of various organs during embryogenesis, including the salivary glands, hemocytes, germ cells and Malpighian tubules. Likely acts non-cell-autonomously to provide signaling cues from the mesoderm/musculature to nearby tissues. Mediates salivary gland positioning, at least in part, through activation of the secreted signal Sema2a.
Subcellular location: Nucleus {ECO:0000269|PubMed:27618755}.
Interaction partners:
Sequence:
MLPSCYANGSMLPDNEELVNSMLANPDYLRTQVSPNPLAPSAVGGAGMEGLMCGSFSPAFYYQGIDSFLALHNNIWGLPISFLHNSHRPEKPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQRHCGHPNRYERESGKDSNDGNSSAAEIRSPSEPLSDFDIFCNERPNYSDRITDLHRQYLSVSLGFNSLFNNEARGLRPLPEIRECPDDVDASSSSSKAMQSSMELHEELHSPSAFTPPLNRRETSSSGAPVLAEAFNGIKDVVDAPGSSPVASSNRSKTTLFTIDNIIGKP
Protein: RT1 class I, locus1 (A0A0G2K4S5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MGVTAPPLLLLLLAAALARTQTRAGSHSLRYFKTAVSRPGLGEPRFMEVGYVDDTEFVRFDSDAENPRYEPRVRWMERQRPEYWERETQGAKEKEQTFRVNLRTLLGYYNQSEGDSHTLQLMFGCDVGSDGRLLRGYDQFAYDGRDYIALNEDLKTWAAADVVAQMTRNKWERARYAEKRRANLEGECVESLRRYLELGKETLLRSDPPKAHVTLHPRPEGDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWAAVVVPLGKEQNYTCHMEHEGLPEPLTLRWEAPPSTNSNMEFNVIYVVLGAISAVAIIGAVIIGAVLAVVRKRNTGRKGQGLFPLRFL
Protein: Serine/threonine-protein kinase tricornered (EC 2.7.11.1) (NDR protein kinase) (Serine/threonine-protein kinase 38-like) (Serine/threonine-protein kinase tricorner) (Q9NBK5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Serine/threonine-protein kinase involved in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Together with fry, maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons. Reduces neurite outgrowth by phosphorylating pav, thereby inhibiting its function in microtubule-microtubule sliding.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11102376, ECO:0000269|PubMed:15975907}. Nucleus {ECO:0000269|PubMed:11102376, ECO:0000269|PubMed:15975907}. Note=Trc colocalizes with Mob1 to the cell periphery in wing cells and wing hairs. {ECO:0000269|PubMed:11102376, ECO:0000269|PubMed:15975907}.
Interaction partners:
- MOB kinase activator-like 1
- Cell division cycle 14, isoform A
- MOB kinase activator-like 2
- non-specific serine/threonine protein kinase
- cAMP-dependent protein kinase type II regulatory subunit
- Myocardin-related transcription factor, isoform H
- Protein furry
- Exosome complex exonuclease RRP44
- Dis3 like 3'-5' exoribonuclease 2, isoform C
- Protein phosphatase PP2A 55 kDa regulatory subunit
Sequence:
MMSSRTQDADGASIRFSDHTLDKATKAKVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKETEYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEHIRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQGGEIAKDWVFINYTYKRFEVRNLE
Protein: Rho-GTPase-activating protein BAG7 (Q12128)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts in signal transduction. Activates RHO1.
Interaction partners:
- GTP-binding protein RHO1
- GTPase-activating protein BEM2/IPL2
- Rho-GTPase-activating protein RGD2
- RHO GTPase-activating protein RGD1
- GTP-binding protein RHO5
Sequence:
MFNMNLLSTPSSEEGSPQNRSSSMSSVEGKKDRDTFTNLQNEFDGKVFGVSLEESLKVAQEEVIIQKSTNEIGSIPVVIAKSGKYLKENALDTTGIFRIAGSNKRVRELQAVFSKPPDYGRKFEGWCDFNVHDIATLLKRYLNSLSEPLVPLALYDIFRNPILENPKINEHKEQIIKDYEDIYMLLPQQNRHLILYLAALLNLFARNEKKNLMSASNLAAIVQPSLLSHPKDEMCPKEYEASRTVIEFLILHASDIIPNTEKANKDTMPHAGTVAKFNNITVPEMAIDSDEEDFVHPSIDDHMLPRSRALSDSNNFTIHHHHHHHHALFPSPIDFDNNGLSVPRSFKGRTLSAESLSPRLSKLLGNVGNSSNTGIKDPTERVPRGEHKTKHKQRQSWLRRLTSPSRTQP
Protein: Prolyl 4-hydroxylase subunit alpha 2 (E7ENX0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATT