wanglab/gogpt-training-data huggingface dataset:
Protein: Nocturnin (EC 3.1.3.-) (Curled) (A8JQX3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Because of its association with the CCR4-NOT complex, has a role in mRNA deadenylation and decay. Required at the pupal stage for proper wing morphogenesis after eclosion.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19581445}.
Interaction partners:
- poly
- CCR4-NOT transcription complex subunit 3
- Not1, isoform H
- Protein cycle
- CCR4-NOT transcription complex subunit 4
- ATP-dependent RNA helicase me31b
- Regulator of gene activity
- DNA-directed RNA polymerase II subunit RPB1
- RNA polymerase II-associated factor 1 homolog
Sequence:
MDQKTTGLRENYGHRRQPALGKAMPVTALLLNLESNPLDYSRNDIGAELLEDDDKPPQLFSVTDEPPSPNEEDYKPPNHHEDDGKLAGERHREIPCSNCLKTAPGHLIDRQSAINEMCQRLCGPECRRPQGLTLDGVRQDFLRQYEIAEAVAKTSAMTSTVQMKQRLAARKLEFEKEMEMDEQLGVASPRNDINLGQSSTVAATGMGEFEFEPPRDLLLYLVRMGSFNSAPKINNVDSQDDGLVLPSGLSTPALLQHVQQLRGGGIEQPSLLTRGFLKPLLADEDVADGLRCLKLNSVSRVCSAPVEGDDIRLLQWNILSQTLGQHNDGFVRCPEEALTWEHRKYLIVQEILQNQPDVICLQEVDHFKFLQTVLGSQNYAGIFFPKPDSPCLYIEQNNGPDGCAIFYKRDKLQLQGYDTRILEVWRVQSNQVAIAARLRMRSSGREFCVATTHLKARHGALLAKLRNEQGRDLIRFVKQFAGDTPLLLCGDFNAEPVEPIYATILGCDLLRLGSAYADVKLDREEILHPNADVGEFVAKSMKREPPYTTWKIREEGEECHTIDYVFYTPDRLKIKNCLDFPAGEQIGKNRTPSFQYPSDHFSLVCDFELLPPTENGKESGSGSGSDGENETEVEGSKHGSIQ
Protein: Uncharacterized NOC2 family protein C1142.04 (Q9P7G0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Nucleolar complex-associated protein 3
- Pescadillo homolog
- Ribosome biogenesis protein erb1
- AdoMet-dependent rRNA methyltransferase spb1
- Probable rRNA-processing protein ebp2
- Ribosome assembly factor mrt4
- Uncharacterized protein C4F10.09c
- Ribosome biogenesis protein rlp24
- Ribosome biogenesis protein ytm1
- Uncharacterized RNA-binding protein C1827.05c
Sequence:
MVKLSSIIKARKANALAKKNDKIKKKDTDKGIRQKHSKKEGKDETLKRDVEKFIQNVNSEDTPSEDDSMSMDAFLEGGFEELDSANSNDAGSSRKRKNLPNENTQDSTSESSEEEEDGLESYQKQLEGLKEKDPEFYKFLEQNDQDLLEFNAAETDAMAKEIDENERLKSSSGKIVLTSDTIQQWQKLLETNHSLTTLQKVVQAFKAAAFLNEEEAEDLKYTISDSKVFNDLLLLAIQYVPKVLNYHVPIQEDAKGKKFINTDSKVLPKLRPVLKSYGFSILRLLEGMTDAKNISLLLREAQNVLPYMITYRKFLKQFTQATVEVWSSTRDDSVRFSAVVLLRTLCLTADITLLEFVLKEVYLGMARQSAYTTVHTLDKINFLKNSAVNLFLLDAESCYLIGFRYIRQLAITLRNTIHQPSKDSRKPVQSWSYVHSLDFWARLLSQAAWLSREKGVASELQSLVYPLVQIALGVIMSSPSSQLFPMRFHIIRSLIYLSRHTGVFIPLAPSLFEVLDSSYVSRKAKASTLKPLDFDVELRASSSYLRTKVYQDGLIDQLLELLSEYYVLYATDISFPELVIPAIVRSKRFAKRSKNAKLNRGLLTLVNRLEQQSKFMTEKRNQQKFAPIDSDSVEQFAQTIDWQQTPLGIYVVTQRQTREEQRKLIRESVQQDQEHKEQMRQKKKQALKSDDIELDDLSEEEAEDIDE
Protein: Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) (P25102)
Organism: Rattus norvegicus (Rat)
Function: The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Histamine H1 receptor
- Histamine H4 receptor
- Neuroendocrine secretory protein 55
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Potassium-transporting ATPase alpha chain 1
- Potassium-transporting ATPase alpha chain 2
- Histidine decarboxylase
- Gastrin
Sequence:
MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
Protein: Histone H2A.Z (P48003)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Important for chromosomal structure and function, possibly including a role in controlling the fidelity of chromosomal segregation during mitosis. Plays an important role in maintaining a silenced chromatin state at centromeres and in the architecture of anaphase chromosomes.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Chromosome {ECO:0000269|PubMed:17947424, ECO:0000269|PubMed:19910462}.
Interaction partners:
- Helicase swr1
- SWR complex protein 2
- Histone H4
- Protein AF-9 homolog
- SWR1 complex subunit vps71
- Actin-like protein arp6
- RuvB-like helicase 1
- SWR1-complex protein 4
- RuvB-like helicase 2
- SWR1-complex protein 5
Sequence:
MSGGGKGKHVGGKGGSKIGERGQMSHSARAGLQFPVGRVRRFLKAKTQNNMRVGAKSAVYSAAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAGGGVLPHINKQLLIRTKEKYPEEEEII
Protein: HTH-type transcriptional regulator HdfR (H-NS-dependent flhDC regulator) (P0A8R9)
Organism: Escherichia coli (strain K12)
Function: Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
Interaction partners:
- Macrodomain Ori protein
- HTH-type transcriptional activator AaeR
- Uncharacterized HTH-type transcriptional regulator YeiE
- Nitrogen assimilation regulatory protein nac
- Transcriptional activator protein LysR
- HTH-type transcriptional activator TtdR
Sequence:
MDTELLKTFLEVSRTRHFGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRHRNNIRLTAAGEKLLPYAETLMSTWQAARKEVAHTSRHNEFSIGASASLWECMLNQWLGRLYQNQDAHTGLQFEARIAQRQSLVKQLHERQLDLLITTEAPKMDEFSSQLLGYFTLALYTSAPSKLKGDLNYLRLEWGPDFQQHEAGLIGADEVPILTTSSAELAQQQIAMLNGCTWLPVSWARKKGGLHTVVDSTTLSRPLYAIWLQNSDKNALIRDLLKINVLDEVY
Protein: Uncharacterized protein ZSWIM9 (Q6DI92)
Organism: Mus musculus (Mouse)
Interaction partners:
- Zinc finger SWIM domain-containing protein 1
Sequence:
MELTEPLPSAAVQKEEQELLDRTFFSWAEFSRFFDKWCQQRLVVFSVKSSTRVARSPWANTPPLYRLIHVLKYSYVLLVCKDVRMPNKSTAWPPQPSCPAFITVKLSPLRDRLVVTECQLTHSHPACPREFAYHFRPGHLLANSCLPVRITNQISKQFVAPADVRRLLTHCKGPDHGVLDALQVLEGLFRTDPEAKVKLVFVEDQAMVETVFLLTSRTRALLRRFPRILLVDRLPGLQGTLDLMAVLCVDSAGRARQAACCVARPGTPSLLRFMLVSLLQSAPDVKGRVRCLTAGPEVAGQLRAVRQLLPCARVQICRAQGLETLFSKAQELGGASQEDPDLWPLLCRLADSKSYTAYSEALAELRSQAPTAFIRYFEHNWAPRHDMWVRFRAYEATRDLDACALVRSHRRRLLRRLSPSHSVAQCLRDLVAMQWADATGEAALRGC
Protein: Ceramide very long chain fatty acid hydroxylase SCS7 (Ceramide VLCFA hydroxylase SCS7) (4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase SCS7) (EC 1.14.18.6) (Dihydroceramide fatty acyl 2-hydroxylase SCS7) (EC 1.14.18.7) (Sphingolipid alpha-hydroxylase) (Suppressor of calcium sensitivity 7) (Q03529)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Sphingolipid C4-hydroxylase SUR2
- C-4 methylsterol oxidase ERG25
- Delta
- Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2
- Mannosyl phosphorylinositol ceramide synthase SUR1
- Acyl-CoA desaturase 1
- Lanosterol 14-alpha demethylase CYP51
- Serine palmitoyltransferase 2
- Ceramide synthase LAC1
- Serine palmitoyltransferase 1
Sequence:
MSTNTSKTLELFSKKTVQEHNTANDCWVTYQNRKIYDVTRFLSEHPGGDESILDYAGKDITEIMKDSDVHEHSDSAYEILEDEYLIGYLATDEEAARLLTNKNHKVEVQLSADGTEFDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYE
Protein: GH23271p (Tropomodulin, isoform B) (Q9VA56)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MESALPVAEFQQIKLRPVPKVKRRAPQPPVSLRLKHKNTSATTKTTTLTTPAKLYGKDLSEYDDVDVESLLAQLSPEEITILAKEVDPDDNFLPPDQRNSYECTKEATGPLNRKQLIEHINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEEIIDLAAILGFHSMMNQDQYHASLLNKGQPVGLGWDGITKSTQQKLFPMDPPNNTDVEESIKRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGLHLEFNDARHRVAAHLQRNIDRIRVKRLNQRK
Protein: Dynein light intermediate chain (G5ECK7)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU366047}.
Interaction partners:
Sequence:
MPPTAQPLEFDDTANAVLPVLYSSTDEEVGIWRELLASKKTNTNQGSTVIVLGDNRSGKSSLLSRLDKSDRTVKPKSLLGYRVLHVQNDARDASYAYQLGTAGANLNPSELLQIPVWSLDGNAACASLLKHALPATPAEAIFILTASIDNPNLIHSLKRWANVCTEQAQKHFTKEDLKAGRSQQEKMWQEYVDPVQSQMSTSVVGSFADEHNLLPLDQGTLTENCGVTFMVVITKSDLGKEFTDAQFAKISIQLRKFCLSLGATLVFTSAKETKNIQLLQKYIVHRSFGTAFTSAAQVIERESIFVPAGWDGEKKIDIIRESIPDVDSALEPTRDKLRPVAKEQLIEAEEDQAFLKKLMDILATSTTTAAPKPRTMQEEPTDKDSPLANFFSNLLNKDKPSKVSSPSTVSQPMDAAATQAQLDRLLKSAQSPKPQPRDSDA
Protein: Small ribosomal subunit protein uS17A (40S ribosomal protein S11-A) (RP41) (S18) (YS12) (P0CX47)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein eS26A
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS2A
- Serine/threonine-protein kinase RIO2
- Nucleolar complex protein 14
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS14B
- Small ribosomal subunit protein eS27A
- Small ribosomal subunit protein eS10A
Sequence:
MSTELTVQSERAFQKQPHIFNNPKVKTSKRTKRWYKNAGLGFKTPKTAIEGSYIDKKCPFTGLVSIRGKILTGTVVSTKMHRTIVIRRAYLHYIPKYNRYEKRHKNVPVHVSPAFRVQVGDIVTVGQCRPISKTVRFNVVKVSAAAGKANKQFAKF
Protein: Gap junction beta-5 protein (Connexin-31.1) (Cx31.1) (O95377)
Organism: Homo sapiens (Human)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Interaction partners:
Sequence:
MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL
Protein: Hepatoma-derived growth factor-related protein 2 (HRP-2) (Q3UMU9)
Organism: Mus musculus (Mouse)
Function: Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (By similarity). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (By similarity). Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity). Associates with chromatin.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q925G1}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:22212508}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:22212508}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:22212508}. Note=Displays a punctate pattern and colocalizes with N-terminally processed HDFG. {ECO:0000269|PubMed:22212508}.
Interaction partners:
Sequence:
MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEADLGCGSDVDKDKESRRVMTVTAVTTTATSDRMESDSDSDKSSDHSGLKRKTPVLKVSVSKRARRASSDLDQASVSPSEEDSESPSESEKTSDQDFTPEKKTAARPPRRGPLGGRKKKKVPSASDSDSKADSDGAKEEPVVTAQPSPSSSSSSSSSSSSDSDVSVKKPPRGRKPAEKPPPKPRGRRPKPERPPSTSSSDSDSDSGEVDRISEWKRRDEERRRELEARRRREQEEELRRLREQEREEKERRKERAERGGSSGEELEDEEPVKKRSRKARGRGTPSSSDSEPEGELGKEGKKLAKKSQLPGSESARKPGQKEKRGRPDEKPRARPVKVERTRKRSEGLSLERKGEKKKEPSVEERLQKLHSEIKFALKVDNPDVRKCLSALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMAKAAEVYTRLKSRVLGPKVEALQKVNKAGAEKERADNEKLEEQPGEQAPRELAEDEPSTDRSAPVNGEATSQKGENMEDRAQEDGQDSEDGPRGGSSEELHDSPRDNSDPAKPGNERQDHERTRLASESANDDNEDS
Protein: Structural protein MDM1 (Mitochondrial distribution and morphology protein 1) (Q01846)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for mitotic growth. Mediates organelle inheritance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1378448}.
Interaction partners:
- Uncharacterized protein YDR179W-A
- Bud site selection protein RAX1
- Regulator of G-protein signaling 2
- Nucleus-vacuole junction protein 1
- Guanine nucleotide-binding protein alpha-2 subunit
- Vacuolar protein 8
- Nucleus-vacuole junction protein 2
Sequence:
MPKFPQFRLILVLFYLISMIQWSVITFSLGFFLNVCIFAYFVFFKSLPDLPKPQPRFVDIVPESSNTVDVDKELKSVEGLIQDGNAQIGKELESIVNLIIKDFVQPWFTKIDKNSDAEFLKVIKWRLLQTLLVVKDKLMKNDSASLIVLKLLPIFNKHFSTFCDAREAVLSDLTLERHKSANIDLQIAVEFNKNYKIHKSLSLKPNALQKEIEKSIRKTVIGLLPHLFDNDELDSLLVFTLMTEVLTTCIISPLIFKFTDPDSWNLRIVSLSQNYFEEKHKVHKIRRMLSKELQDHRKVMNDVANKDVGEPSSEKLELNAEYTGKQFEHYLNQLDSLLDLSDIKYVAYSLALKIYQLKENEHLTKENLKYKKRLLLSLNLIESKLSFPGSEIDTASKKLAREANYPDLNMDNGIVLKEMASFLTSITLKDIVDDSEFLPFFESFLGSVPETQGSTFLEYSQTIESFKNPLEDATSEDIISGYSGISTMQLQEISSKFFHNNNLQNMKLLDEGLVKNIILFRNSFQINNDEDTFILARKSVLLLQTEAIKYLDDRFLPLFKKTPSFLKMLSTSHIISTDIYAHFLSRIGGVNNPEQNKIIKDNVKTDFMNPVRIFANPGITDALDNIVNGSGSKPHKSRISSNPRYSQLFGSENDNIFKDKLFDDENDNTSEISVVEDQLDHPRNMEKVSVSSGNSGLNPSQFYGSNNFRDNIASLTISIDQIEKELELLRHLILKADLTNNQMQLKILKKSQRTLLKELEMKELLKQQYMVQENGNSLFRKTKIYIRSYFSENSSNGLKEITYYIINIHHFNNGQVSSWDMARRYNEFFELNTYLKKNFRDLMRQLQDLFPSKVKMSLKYHVTKTLLYEERKQKLEKYLRELLSISEICEDNIFRRFLTDPTPFKLNKEYMHDDILEEPLHEPIGSSNSTSNSSSVVDLQSSEDGGELNFYEDERHFFTDSGYPFYSQNKSFVKQICDLFISLFALNKANAGWLRGRAIITVLQQLLGSTIEKYIKVSIQKLRSEDQVFEAIVTFKNMLWGDNGLFERKRNETAEATRSEGERLRTEQLALTSLQRLFADTCGRVVGLRDSHEAAGRVHAMLQNPYLNASLLLEALDAILLDIICND
Protein: Glycolytic genes transcriptional activator GCR2 (Q01722)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional activator required for the expression of glycolytic genes. Enhances the CT box-dependent transcriptional activation of a RAP1-GCR1 complex. Required for GCR1 phosphorylation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Glycolytic genes transcriptional activator GCR1
- DNA-binding protein RAP1
- Transcription factor TYE7
Sequence:
MHHQTKLDVFIIRAYNLLSNESVISGASLQSVTNSPQTTTNTPSGMVNGAVGTGIANPTGLMGSDSTPNIDEIITSTGSNALTKTNSDSANGTPNGNSSSTSAISNASNPATTGNNASSSATSNGIYTQAQYSQLFAKISKLYNATLSSGSIDDRSTSPKSAIELYQRFQQMIKELELSFDASPYAKYFRRLDGRLWQIKTDSELENDELWRLVSMSIFTVFDPQTGQILTQGRRKGNSLNTSTKGSPSDLQGINNGNNNGNNGNIGNGSNIKNYGNKNMPNNRTKKRGTRVAKNAKNGKNNKNSNKERNGITDTSAFSNTTISNPGTNMLFDPSLSQQLQKRLQTLSQDVNSRSLTGYYTQPTSPGSGGFEFGLSHADLNPNASSNTMGYNTMSNNGSHSWKRRSLGSLDVNTLDDEAVEELLQLTNTSKRQRPMTTAAEGALINDGPDTNLNANNTQMKVDLNPSNSMGPIDTEAVIRPLKEAYDAIISEKGQRIVQLERELELQRQETQWLRKMLIEDMGCVRSMLRDLQR
Protein: Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) (Q6P0N0)
Organism: Homo sapiens (Human)
Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:17199038}. Chromosome, centromere {ECO:0000269|PubMed:17199038}. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. {ECO:0000269|PubMed:17199038}.
Interaction partners:
- Protein Mis18-beta
- Protein Mis18-alpha
- Holliday junction recognition protein
- Centromere protein C
- Centromere protein I
- Histone H3-like centromeric protein A
- Histone-binding protein RBBP7
- Rac GTPase-activating protein 1
- Dual specificity protein kinase TTK
- Centromere protein N
Sequence:
MIATPLKHSRIYLPPEASSQRRNLPMDAIFFDSIPSGTLTPVKDLVKYQNSSLKLNDHKKNQFLKMTTFNNKNIFQSTMLTEATTSNSSLDISAIKPNKDGLKNKANYESPGKIFLRMKEKVLRDKQEQPSRNSSLLEPQKSGNNETFTPNRVEKKKLQHTYLCEEKENNKSFQSDDSSLRASVQGVPLESSNNDIFLPVKQKIQCQQEKKAPLHNLTYELPTLNQEQENFLAVEARNKTLTRAQLAKQIFHSKESIVATTKSKKDTFVLESVDSADEQFQNTNAETLSTNCIPIKNGSLLMVSDSERTTEGTSQQKVKEGNGKTVPGETGLPGSMKDTCKIVLATPRLHITIPRRSKRNISKLSPPRIFQTVTNGLKKNQVVQLQEWMIKSINNNTAICVEGKLIDVTNIYWHSNVIIERIEHNKLRTISGNVYILKGMIDQISMKEAGYPNYLIRKFMFGFPENWKEHIDNFLEQLRAGEKNREKTKQKQKTGRSVRDIRKSMKNDARENQTDTAQRATTTYDFDCDNLELKSNKHSESPGATELNMCHSNCQNKPTLRFPDDQVNNTIQNGGGDDLSNQELIGKKEYKMSSKKLKIGERTNERIIKSQKQETTEELDVSIDILTSREQFFSDEERKYMAINQKKAYILVTPLKSRKVIEQRCMRYNLSAGTIKAVTDFVIPECQKKSPISKSMGTLENTFEGHKSKNKEDCDERDLLTVNRKIKISNLEKEQMLTSDFKKNTRLLPKLKKIENQVAMSFYKHQSSPDLSSEESETEKEIKRKAEVKKTKAGNTKEAVVHLRKSTRNTSNIPVILEPETEESENEFYIKQKKARPSVKETLQKSGVRKEFPITEAVGSDKTNRHPLECLPGLIQDKEWNEKELQKLHCAFASLPKHKPGFWSEVAAAVGSRSPEECQRKYMENPRGKGSQKHVTKKKPANSKGQNGKRGDADQKQTIKITAKVGTLKRKQQMREFLEQLPKDDHDDFFSTTPLQHQRILLPSFQDSEDDDDILPNMDKNPTTPSSVIFPLVKTPQCQHVSPGMLGSINRNDCDKYVFRMQKYHKSNGGIVWGNIKKKLVETDFSTPTPRRKTPFNTDLGENSGIGKLFTNAVESLDEEEKDYYFSNSDSA
Protein: Peptide chain release factor PrfB1, chloroplastic (AtPrfB1) (AtPrfB) (Protein HIGH CHLOROPHYLL FLUORESCENCE 109) (Q9LVY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Directs the termination of translation in response to the peptide chain termination codon UGA. Required for the proper translation, stability and normal processing of UGA-containing polycistronic transcripts in chloroplasts.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:12468741, ECO:0000269|PubMed:21771930}.
Interaction partners:
- Putative E3 ubiquitin-protein ligase RF4
- Large ribosomal subunit protein bL9c
- At5g64156
- AT3g13440/MRP15_7
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Large ribosomal subunit protein bL27c
- Large ribosomal subunit protein bL31c
- 50S ribosomal protein L33
- Ribosome-recycling factor, chloroplastic
- Ribosome-recycling factor, chloroplastic
Sequence:
MSMELTVLGPLAGRSFAIAGKPKLLLLRPTNLPLLRLSLPLSLPNFSSSSRFNSPIVFAAQESNLSVSNENETSEWLMQDFYTLRKDVEIASARVEEIRASANLQQLEQEITNLESKATDTSFWDDRTKAQETLSSLNDLKDRMRLLSEFKTMVEDAETIVKLTEEMDSTDVSLLEEAMGIIKELNKSLDKFELTQLLSGPYDKEGAVVYITAGAGGTDAQDWADMLLRMYMRWGEKQRYKTKVVEMSNGEEAGIKSATLEIEGRYAYGYISGEKGTHRIVRQSPFNSKGLRQTSFSGVEVMPLLPEEAVGIEIPEEDLDISFTRAGGKGGQNVNKVETAVRITHIPTGVAVRCTEERSQLANKTRALIRLKAKLMVIAEEQRATEIKEIRGDAVKAEWGQQIRNYVFHPYKLVKDVRTGHETSDITSVMDGDLDPFIKAYLKHKYTLAMASAVTN
Protein: Bromodomain and PHD finger containing 1 (A0A5F9ZH11)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYHYDHDNPPPPQQTPLRKHKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVSEDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDSNHHHHHNVSASTTPKLPEVVYRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCCICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEDEDEEEDEGKGWSSEKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRLHSYWTLKRQSRNGVPLLRRLQTHLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLERARLLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVTELDEVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKMGIDFETGMHIPHSLAGDEATHHTEDAEEERLVLLENQKHLPVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPSSRGSLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPKTAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMSSLRQRKRGRSPRPSSSSDSDSDKSTEDPPMDLPANGFSGGNQPVKKSFLVYRNDCSLPRSSSDSESSSSSSSSAASDRTSTTPSKQGRGKPSFSRGTFPEDSSEDTSGTENEAYSVGTGRGVGHSSKFPCPRPGMLGTQCQGLASPPAADPPPLPHSCEVVRKSLGRGAGWLSEDEDSPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEAREHLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKVQGEQSSETSDSD
Protein: C3H1-type domain-containing protein (Q20155)
Organism: Caenorhabditis elegans
Interaction partners:
- MAP kinase-activated protein kinase mak-2
- MAP kinase-activated protein kinase mak-1
- Serpentine Receptor, class T
- Serine/threonine-protein kinase akt-2
- Serine/threonine-protein kinase akt-1
- GILT-like protein F37H8.5
- CCCH-type zinc finger protein moe-3
- Large ribosomal subunit protein mL44
- 5'-3' exoribonuclease 1
Sequence:
MFEFGSLSSQHTTLFDSGLSSALTNSTSNSITSGSPPTAFSSNYIDQPGLLFKSLCSADNGVGVPSHSINGFGSTPSTQSSPTSAPNTIESLLEPFGLQNSQADFAAALAQLTGQSVKQMDRQQASAIQRPTSFAGSSLFGASEFGNPLGAPGTPIGSQHQMSIGQNLVSASSPYSTPQLTPMATPNGQAPPPKNPKLYKTELCRSWMDHGRCNYGERCQYAHGELEKRPVPRHPKYKTEACQSFHQSGYCPYGPRCHFIHNEPPSAQSQYSTPISTPVPHQTTPSLYASQYHNVTMKQQQPTQNASNVPNNVLQRVYSLPNGGYGSAGESPPCSSNDSGSESPNGSFSPGLDLEDSGPFSAGFLSASPHKLQQQKTNAAPRVPTSRFLSYDQSNLNDSQFSNLLNDICQWNIEDSLSTPFSGFLPSKWSTTTEETSPATTTPVSTPGRLPVFAQLSNPQ
Protein: SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) (Q9H788)
Organism: Homo sapiens (Human)
Function: Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18641339}. Note=Located at podocyte foot processes. {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Protein phosphatase 1 regulatory subunit 7
Sequence:
MLKQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDQLPDYLELFE
Protein: Synaptogyrin-3 (O43761)
Organism: Homo sapiens (Human)
Function: May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8R191}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q8R191}. Note=Found at the neuromuscular synapses. {ECO:0000250|UniProtKB:Q8R191}.
Interaction partners:
- Sodium-dependent dopamine transporter
- Synaptophysin
- Synaptotagmin-1
Sequence:
MEGASFGAGRAGAALDPVSFARRPQTLLRVASWVFSIAVFGPIVNEGYVNTDSGPELRCVFNGNAGACRFGVALGLGAFLACAAFLLLDVRFQQISSVRDRRRAVLLDLGFSGLWSFLWFVGFCFLTNQWQRTAPGPATTQAGDAARAAIAFSFFSILSWVALTVKALQRFRLGTDMSLFATEQLSTGASQAYPGYPVGSGVEGTETYQSPPFTETLDTSPKGYQVPAY