wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein YddE (P96642)
Organism: Bacillus subtilis (strain 168)
Interaction partners:
- Bifunctional muramidase/DL-endopeptidase CwlT
- Ftsk domain-containing protein YdcQ
- Uncharacterized protein YddF
- Putative DNA relaxase NicK
- Uncharacterized membrane protein YddG
- Metallopeptidase ImmA
- Uncharacterized protein YddD
- Putative uncharacterized protein YdcP
- Uncharacterized protein YddC
- Uncharacterized protein YddB
Sequence:
MRLKTPMKAIHKNLLLTRTGDVWAYYRIKSNSIPMQNKEKVESYKKKWQHLFEEITSYEDFHLMMYPSEYELEKRFKDLETDIAADAMDVARYYNEETVRLLEQRLGRLTKYDFILGVKLKSSLVNISVELKDNILSFFNTATDTVVKMLGWEQNVSTSFFEKYEEVEETLANIMASVRGERLSETEMTYINRYHFVRGLKHQTNEESEIKDVRSITNTIIDPTDPSVLHLHSDQDEGYSAFVVIDEFLHNMSESDLFYEAQSLPFPVEVQMKIQTESKSITKPALNLKRQQLKEEQKEQQSTGDRSDVSTVTSATMIRHLQDEIKKEDVHVMNWLSVIVVHGKTKKECVGKATIVKRHLKGAGITCRLPVADQLNLFYKMLPGEKLDITDKNWIQKTTQDGVAESLFAVNSDIGSKIGFFLGWVDRFQEHTDLESAIMSSRDFVLFHPFLANQQLKGSKTRSPHCLITGDTGNGKSYLAKLIFNYISMLNIKSLYIDPKKEMRKWIQRVLNDEYIRENFPLYIAHLEKYNYITLDHENTHNWGALDPISFLPPMKAKELVQVIFEQVYDFKGKDDINTAFLRATSEVIDAKQKGEQVGSLDIIRKMQSHPEEAVQKAGDYLNEVVSDSILKLCIHDGSNPALSLEKRITILEVENMDLPDHAERLENYTISQLKSSAVMFALGKFCELFGMNQDEQTVEFIDEAWIFTTSQQGKKVERQMRRIGRSYNNAEYFISQSTKDALKEEDSGNFGVAFAFDEPNEREEVLKWMNMEVTKDNKKMMESMFQGQCLFKDYYGRTSKISIECLFEEWQGALKTVEKKAVAYAEEKYL
Protein: Homeobox protein MSH-B (Q03356)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable morphogenetic role.
Subcellular location: Nucleus.
Interaction partners:
- Fibroblast growth factor
Sequence:
MNSPKGPVETTSQEKSESDSEESQKPRDMTADTGHKAKKTYLPFSVESLMAKSSCQQVACSPALQHQRMGHGQDLVRTYFVEKAKVSVDTLSSVSDSLNDDSEELSDKEQSTWSNSSSFTSPPRHPSPTPCTLRKHKTNRKPRTPFSTSQLLSLERKFRQKQYLSIAERAEFSNSLNLTETQVKIWFQNRRAKAKRLQEAELEKFKCASKPLLAPFALPFPLGSPSSLYGPPASFPRPVPMPGLFNGPVSYGMYYLS
Protein: Integrin beta-6 (Q9Z0T9)
Organism: Mus musculus (Mouse)
Function: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P18564}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P18564}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P18564}.
Interaction partners:
- Integrin alpha-V
- Fibronectin
- Transforming growth factor beta-1 proprotein
- Focal adhesion kinase 1
- Integrin alpha-3
- Proto-oncogene tyrosine-protein kinase Src
- Actin, cytoplasmic 1
- Integrin alpha-5
- Integrin alpha-1
- Integrin alpha-2
Sequence:
MGIELVCLFLLLLGRNDHVQGGCAWGGAESCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPANLLAKGCQLPFIENPVSRIEVLQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGREQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFGFKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDHRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCNNGVLFPHQKKCSHMKVGDTASFNVTVSVSNCEKRSRNLIIKPVGLGDTLEILVSAECDCDCQREIETNSSKCHNGNGSFQCGVCTCNPGHMGPHCECGEDMVSTDSCKESPGHPSCSGRGDCYCGQCICHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDCDCGECVCRDGWTGEYCNCTTNRDSCTSEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDPCNSKRSCIECYLSADGQAQEECADKCKAIGATISEEDFSKDTSVSCSLQGENECLITFLITTDNEGKTIIHNINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKHKAGLSSDG
Protein: TIA1 cytotoxic granule associated RNA binding protein (F8W8I6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQNQIGYPQPYGQWGQWYGNAQQIGQYMPNGWQVPAYGMYGQAWNQQGFNQTQSSAPWMGPNYGVQPPQGQNGSMLPNQPSGYRVAGYETQ
Protein: Uncharacterized protein, isoform J (Q7KTI6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGGNVEQRPWTPTVRIGKIAAETTNPGPATVQLPTLIGSKVPDSKKKAAPSYSFGHKLGGKYDTSGPGPAQYNVTGMRAKGRDYPRAATLQSRPKELTRFSNPGPGEYDVVPAAKAVIDATPKYTFGQRPVALKTFQIPAPGAYCPEKVKLNKTPEFSFGIKHHEQRPDYTPAPGTYKPEQVVLEHIPAYSFGLKTKHIQVSDTPAPGAYSPEKSRLHSAPAYSIAGKASQDVVDCTPAPGAYEPEKCVLSRTPAFSFGHRAELAKSSDTPAPGTYNPEKVRLDHTPAFTLSGRPETRSVSETPAPGSYAPEKYRNDRTPAFTFGGKHEQRLESSTPAPGDYCPEKVRHDHNPAFSFAGRHDLHKPSDTPAPGAYDTEKVRQDHNPAFSFAGRHDLHKPSETPAPGAYSPEKVRQDHNPAFSMAGKHSQKVTSDSPAPGDYCPEKVRLDHTPAYSFGVKSDPKVENNTPAPGDYHPEKVRQDHNPAYSFAGRHDLQKPDNTPAPGAYFPEKVRLDHNPAFSMAGKYDAKVTNDTPAPGDYSPEKVRQDTNPAYSFAGRHDLHKPSETPAPGAYSPEKVRLDHNPAFTMAGKHDQKILNGTPAPGDYSPEKCRLDHTPAYSFGGKNDPKVENNTPAPGDYHPEKVRLDHNPAYSFAGRHDLQKPSDTPAPGAYSPEKVRQDHNPAFSMAGKPVEKLTNGTPAPGDYSPEKVRLNHTPAYTFGGKNDPKVENNTPAPGDYHPEKVRQDHNPAFSFAGRHDLHKPNDTPAPGAYCPEKVRQDHNPAFSMAGKYTQKVANDTPAPGDYSPEKVRLDHTPAYTFGGKNDPKVESNTPAPGDYHPEKVRQDHNPAFSFAGRHNLQKPSDTPAPGAYSPEKVRQDHNPAFTMAGKHDPKVSNDTPAPGDYSPEKVRLDYTPSFTFAGKNNPKVENDTPAPGDYHPEKVRQDHNPAFSFAGRHDLHKPSDTPAPGAYSPEKVRQDHNPAFSMAGKYIEKITNGTPAPGDYCPEKVRLDHTPAFTFGGKNDPKVENNTPAPGDYHPEKVRQDHVPAFSFAGRHDLHKPNETPAPGAYSPEKVRQDHNPAFTMAGKHDPKVTHDTPAPGDYHPEKVRLDHNPAFSFAGRHDLHKPSETPAPGDYFPEKVRQDFNPAFTFAGKHDPRSLSESPAPGDYSPEKVRLDHAPAFSFGGKHDPKTEHLHPAPCDYAPEKVRLDHTPAYTIAGRPAADHVSQTPAPCDYHPEQCQVDSTPAFTFGMRLGRERISDTPAPGHYHPEQCKLDSSPAYSFGLKTVPTASLPVRNNAECTTTTTNHTNNNAGSSTTTTTTTTTTTKTFINGVEQPELQKKETTKQVNGTHKELKSAPQAPLSNGNIVSNGNHSKMVSTTTRIQEVAHGQKESGNLKVVASGKSDASATKAAAVSHQTVVQADGAIVTSGQSSRMQTVKYAVEASSVQEKIISS
Protein: Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) (Q6ZWJ1)
Organism: Homo sapiens (Human)
Function: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Syntaxin-4
- Synaptosomal-associated protein 23
- Solute carrier family 2, facilitated glucose transporter member 4
- Vesicle-associated membrane protein 2
Sequence:
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPITSENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELPNQKS
Protein: BimD protein (Q5AWN4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Double-strand-break repair protein rad21
- Sister chromatid cohesion acetyltransferase Eco1, putative
- DNA polymerase eta
- Chromosome segregation protein sudA
- Nuclear cohesin complex subunit
- Chromosome segregation protein sudA
- Rad21/Rec8 N terminal domain protein
- Sister chromatid cohesion protein
- Structural maintenance of chromosomes protein 5
- Nuclear condensin complex subunit Smc4, putative
Sequence:
MPSRTRQGPSVATEDVEPEEPSGGLRQLKFNEPLSWRVGRSAIPIADLLQRLQTLAQELRKLEQEEIEKESLRKVSQELATAQLLAHKDKGVRAWATCCIVDVLRLCAPDAPFTANQLKDIFTCIVSSIIPALGDPSNPYNAQHIYVLNSLAEVKSIVLMTDLDHPDTLIVPLFISCFDIVAGSAKASTGEPVAKNVEYDMTRLLVTVIDESPVLAPDVVDVIVAQFLRVDPRVLDGPGKKGKKPETQVDEKQETLLLKDYPAAYNMAKAICQACPERMTSHISQYFNNVIIDASATGTQNGPSKQARRTNLDDSDEEGEDIKELSKAHRLIRELWRACPDVLQNVIPQLEAELSAESVSLRLLATQTIGDLTSGTGVAGPPPPLPMDPAVYPQVKLDDYARSIPQPNVLLMPFAPKPFSQAHSSAYDSFLSRRLDKSASVRASWATAIGRIILTSAGGSGLSDNEEQTLITHLSSMLRDADERVRLAAVEAVGTFGLSHIVNKLGVSGGVSTQDSLLFILAERVKDRKSQVREHATKVLARAWAVASGDIERSHEQVTPLLKEAPSRILDAYYTNDPEIHVSIDRAMFEILLPLSYPPIKPKLSRSSSSQSQRLKDSQAAEPESEADVDRIRVRRILTLVGGLDEKAKKVFFAMQKRQVSLRTAVTVYLQACEEYNGGVMEKNKDQIKAQLTKIVDALAKTFPDPARTSADLWKFAKIHDRRGYQLIRFAMAAVSDYRTVIKAIKELARRLQSSNNTILHETLTTLLYRCSSIVFNRSHIPAIMSISRSDENGLAAPAHEMLKEISSLNPEVLEAQVQEICKDLEAQAPKATTVSAAGTEEILKACSGFAKKLPSKLPKERKFFQALVDYALHSPSPRAAKHAVLILMAVTDKKNMYAKDLVEKCVSKCTYDSERFLTKLATLSQLNLLAPREADEESDAIIKISVNQILLTNRSPTPNSGYFWSDQVDDETAAKEWALKIIVNRLRAKDGSDSDDDFRAHAEPVYDTLNKLIVNSGELSKKKDTPATQKSRLRLLAANSLLKLCSSHALCEQLLTPQDFNSIALVAQDPLPEVRSGFINQLKKKLVQDTRLGARWYVIPYLLAFEPQVGLKDSTLTWLRSRAAFFSQQTNGKKGEKQTVMEALFSRLLSLLAYHPDYPPADLDESTKLDELTDFARYILFYLSAVANEHNLSLIFHIAQRVKQARDGITKSDEMSRRLHTLSDLAQATIRRFADVYSQQRRFGGGAGGVNLLQTYPGKVGVPSSIFAPMGSHREAQEVADTTFLPEDAEDRLDRIVRATMRTKNGSSQAGAKKRKTDSTQEPSRDANAAKKARKNSESSSRRKSGSSAVGFKMPKRKSTKKTGDDWSSDGEAAGNVASSSATRRRSNRGSASRRISYADPDSDEDDMEMDELNQARDDEDEGEDQAKDIENGSDLSELSEADSNMLEEPEDDDGPSEKEDQPDDKQNGDDDAQPASPVPVASKAKVPGKAMKKATLPTRRSARR
Protein: GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) (Q14C86)
Organism: Homo sapiens (Human)
Function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.
Subcellular location: Membrane {ECO:0000269|PubMed:16410077}; Peripheral membrane protein {ECO:0000269|PubMed:16410077}. Endosome {ECO:0000269|PubMed:16410077}. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.
Interaction partners:
- Ras-related protein Rab-5A
- Alsin
- Casein kinase I isoform epsilon
- Casein kinase I isoform delta
- Ras-related protein Rab-31
- Ras and Rab interactor 1
- Early endosome antigen 1
- Ras-related protein Rab-5B
- Casein kinase I isoform alpha
- Sorting nexin-24
Sequence:
MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGSDRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGDPRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNFMKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPIATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSPRLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDGESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
Protein: Beta-defensin 9 (A0A0N9WLX3)
Organism: Gallus gallus gallus
Subcellular location: Cytoplasmic granule {ECO:0000256|ARBA:ARBA00004463}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRILFFLVAVLFFLFQAAPAYSQEDADTLACRQSHGSCSFVACRAPSVDIGTCRGGKLKCCKWAPSS
Protein: Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94) (P83581)
Organism: Rattus norvegicus (Rat)
Function: Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.
Subcellular location: Cytoplasm. Nucleus. Note=May translocate to the nucleus of germ cells after heat shock.
Interaction partners:
Sequence:
LSAMLEDTENWLYEELSLTQDPVV
Protein: Histone-lysine N-methyltransferase SETD1 (EC 2.1.1.354) (Q5LJZ2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:21694722, ECO:0000269|PubMed:21875999}. Chromosome {ECO:0000269|PubMed:21694722, ECO:0000269|PubMed:21875999}. Note=Colocalizes with di- and trimethylated H3 'Lys-4' and with phosphorylated RNA polymerase II at transcriptional puffs on polytene chromosomes. {ECO:0000269|PubMed:21694722, ECO:0000269|PubMed:21875999}.
Interaction partners:
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Retinoblastoma-binding protein 5 homolog
- WD repeat-containing protein 82
- Protein dpy-30 homolog
- CXXC-type zinc finger protein 1
- Protein will die slowly
- Host cell factor
- Histone H3
- Protein dpy-30 homolog
- Histone H3.3A
Sequence:
MQDVRNINLVNNSSNSHDSSLANSKMPRNFKLLSDPQLVKCGTRLYRYDGLMPGDPSYPTITPRDPRNPLIRIRARAVEPLMLLIPRFVIDSDYVGQPPAVEVTIVNLNDNIDKQFLASMLDKCGTSDEINIYHHPITNKHLGIARIVFDSTKGARQFVEKYNQKSVMGKILDVFCDPFGATLKKSLESLTNSVAGKQLIGPKVTPQWTFQQAALEDTEFIHGYPEKNGEHIKDIYTTQTNHEIPNRSRDRNWNRDKERERDRHFKERSRHSSERSYDRDRGMRENVGTSIRRRRTFYRRRSSDISPEDSRDILIMTRERSRDSDSRPRDYCRSRERESFRDRKRSHEKGRDQPREKREHYYNSSKDREYRGRDRDRSAEIDQRDRGSLKYCSRYSLHEYIETDVRRSSNTISSYYSASSLPIASHGFNSCSFPSIENIKTWSDRRAWTAFQPDFHPVQPPPPPPEEIDNWDEEEHDKNSIVPTHYGCMAKLQPPVPSNVNFATKLQSVTQPNSDPGTVDLDTRIALIFKGKTFGNAPPFLQMDSSDSETDQGKPEVFSDVNSDSNNSENKKRSCEKNNKVLHQPNEASDISSDEELIGKKDKSKLSLICEKEVNDDNMSLSSLSSQEDPIQTKEGAEYKSIMSSYMYSHSNQNPFYYHASGYGHYLSGIPSESASRLFSNGAYVHSEYLKAVASFNFDSFSKPYDYNKGALSDQNDGIRQKVKQVIGYIVEELKQILKRDVNKRMIEITAFKHFETWWDEHTSKARSKPLFEKADSTVNTPLNCIKDTSYNEKNPDINLLINAHREVADFQSYSSIGLRAAMPKLPSFRRIRKHPSPIPTKRNFLERDLSDQEEMVQRSDSDKEDSNVEISDTARSKIKGPVPIQESDSKSHTSGLNSKRKGSASSFFSSSSSSTSSEAEYEAIDCVEKARTSEEDSPRGYGQRNLNQRTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTKRTKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISKDSCIGLDENGIEPTILRKIPNTPKLNEECRRSLTPVPPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSEEEKEYQERRKRNTEYMAQMEREFLEEQEKRIEKSLDKNLQSPNNIVKNNNSPRNKNDETRKTAISQTRSCFESASKVDTTLVNIISVENDINEFGPHEEGDVLTNGCNKMYTNSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSLPPHSVSLGDYPSGKVNETKNILKREAENIAIVSQMTRTGPGRPRKDPICIQKKKRDLAPRMSNVKSKMTPNGDEWPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKEPYAMFLNNTHWVDHCTTDRAFWPPPSKKRRKDDELIRHKTGCARTEGFYKLDVREKAKHKYHYAKANTEDSFNEDRSDEPTALTNHHHNKLISKMQGISREARSNQRRLLTAFGSMGESELLKFNQLKFRKKQLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFPLEDEKIPCLCGAQGCRGTLN
Protein: SET and MYND domain-containing protein 4 (EC 2.1.1.-) (Q8IYR2)
Organism: Homo sapiens (Human)
Function: Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8BTK5}. Cytoplasm {ECO:0000250|UniProtKB:Q8BTK5}.
Interaction partners:
- Protein-lysine N-trimethyltransferase SMYD5
Sequence:
MDLPVDEWKSYLLQKWASLPTSVQVTISTAETLRDIFLHSSSLLQPEDELFLKRLSKGYLVGKDSDAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHSRPNTEDMSLCHANRSAALFHLGQYETCLKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALADVLPQTLQRNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATVPCDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGFEDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQTEAHRMAAGPRWEAFCCNSCGAPMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQQVRVAQKLLRDGELERAVQRLSGCQRDAESFLWAEHAVVGEIADGLARACAALGDWQKSATHLQRSLYVVEVRHGPSSVEMGHELFKLAQIFFNGFAVPEALSTIQKAEEVLSLHCGPWDDEIQELQKMKSCLLDLPPTPVGPAL
Protein: Negative cofactor 2 complex subunit beta (NC2 complex subunit beta) (Transcriptional repressor YDR1) (Q92317)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the NC2 complex which represses RNA polymerase II transcription through binding to SPT15/TBP and thereby inhibiting the assembly of the preinitiation complex. The NC2 complex may also mediate transcriptional activation from TATA-driven promoters through association with SPT15/TBP.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Negative cofactor 2 complex subunit alpha
- TATA-box-binding protein
- DNA polymerase epsilon subunit D
- TATA-binding protein-associated factor MOT1
- SAGA complex subunit ADA2
- SAGA complex subunit SGF29
- Histone acetyltransferase GCN5
- N-alpha-acetyltransferase NAT5
- Transcription initiation factor IIB
- SAGA complex subunit NGG1
Sequence:
MAGDSDNVSLPKATVQKMISEILDQDLMFTKDAREIIINSGIEFIMILSSMASEMADNEAKKTIAPEHVIKALEELEYNEFIPFLEEILLNFKGSQKVKETRDSKFKKSGLSEEELLRQQEELFRQSRSRLHHNSVSDPVKSEDSS
Protein: Coiled-coil domain-containing protein 167 (Q9P0B6)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MTKKKRENLGVALEIDGLEEKLSQCRRDLEAVNSRLHSRELSPEARRSLEKEKNSLMNKASNYEKELKFLRQENRKNMLLSVAIFILLTLVYAYWTM
Protein: Pentatricopeptide repeat-containing protein At5g39980, chloroplastic (Q9FLD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
Sequence:
MYIEIASSSSLSLPLLPLTRPHIYTSIPFSTIPEARQRNLIFTVSASSSSESTQNKKVWRKQPEKNTTSSFQALRKHRRYQRSAFLDHNVDMDELLASIHQTQNEKELFSLLSTYKDRQLSIRFMVSLLSRENDWQRSLALLDWVHEEAKYTPSVFAYNVVLRNVLRAKQFDIAHGLFDEMRQRALAPDRYTYSTLITSFGKEGMFDSALSWLQKMEQDRVSGDLVLYSNLIELSRRLCDYSKAISIFSRLKRSGITPDLVAYNSMINVYGKAKLFREARLLIKEMNEAGVLPNTVSYSTLLSVYVENHKFLEALSVFAEMKEVNCALDLTTCNIMIDVYGQLDMVKEADRLFWSLRKMDIEPNVVSYNTILRVYGEAELFGEAIHLFRLMQRKDIEQNVVTYNTMIKIYGKTMEHEKATNLVQEMQSRGIEPNAITYSTIISIWGKAGKLDRAATLFQKLRSSGVEIDQVLYQTMIVAYERVGLMGHAKRLLHELKLPDNIPRETAITILAKAGRTEEATWVFRQAFESGEVKDISVFGCMINLYSRNQRYVNVIEVFEKMRTAGYFPDSNVIAMVLNAYGKQREFEKADTVYREMQEEGCVFPDEVHFQMLSLYSSKKDFEMVESLFQRLESDPNVNSKELHLVVAALYERADKLNDASRVMNRMRERGILKPFPG
Protein: Exportin 1 (C8VRM0)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nuclear pore complex protein An-Nup159
- GTP-binding nuclear protein
- Nuclear protein export protein Yrb2, putative
- Nuclear transport factor 2
- Uncharacterized protein
- Ran-specific GTPase-activating protein 1, putative
- Peptidase S59 domain-containing protein
- AP-1-like transcription factor napA
- Ran specific GTPase activating protein An-RanGAP
- 60S ribosomal export protein NMD3
Sequence:
MSVSIQELDTTVQAFYEGKGELQKQAQQTLTEFKQNPDAWLIVGNILQESQYPQTKYLALQVLDDVIMTRWKVLPRDQCLGIRNFIVNFIIENSKSEEKLRSERAFLNKLNLVLVSILKQEWPHNWPTFINEIVSSCHTSLSICENNMAILRLLSEEVFDFSQDQMTSVKARNLKTTMTQEFSSIFQLCSEVLTTANQPSLVKATLETLLRFLNWIPLGYIFETPVINTLLTRFLDVPEFRNVTLKCLTEIGGLQIGHPYNYDERLVHMFTETLTTVSKTIPLSMDLKSTYAKSNSRDQEFVLNLALFLCSFFSAHLNLVEKLPNRDYLTHAHFYLIRISQIDDREVFKICLEYWTRLVQELYEEMQQLPITDINPLVSMGVSGLSNGGAPHPNTLAGYPLRKHKYDEVLSSLRTVMIEKMVRPEEVLIVENEEGEIIREFVKESDTIQLYKTIRECLVYLTHLDVIDTENIMIEKLAKQVDGTEWSWANCNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIANKCRRHFVALQPGENEPFIEEIVRNMRKITCDLSPQQVHTFYEACGYMISAQGQKGLQDRLIENLMSLPNSAWDTIIAQANQDPSVLQDGETIKIIGNIMKTNVAACSSVGTYFYSQLGRIYHDMLNMFRASSQLINDAVARDGDIATKTPKVRGLRTIKREILKLIDTYVQKADDLEMVNANMVPPLLEAVLVDYNRNVPNAREAEVLSVMTTVIQKLHNLMDDKVPLIMESVFECTLEMINKDFHEFPDHRIQFFKLLQAINLYCFPALLKLDATQFKFVIDSCMWASKHDNREVENTGLTMCLELMNNMAEVDVQTSNIFFRQFYIPILQDVFFVLTDSDHKAGFKSQAMLLSRMFYFIESGKIQDPIYSPEQAPIGTSNKDFLQKYVADLLQTAFKNLQEIQIKQFVVGLFAFNDDFNKFKTHLRDFLISLKEFAGDNAELYAEEREQALKDAKAAERDRAMRVGGLLKPSEMDHDDEL
Protein: Sulfotransferase domain-containing protein (Q9TZK5)
Organism: Caenorhabditis elegans
Interaction partners:
- Heparan-sulfate 6-O-sulfotransferase
- Heparan sulfate 2-O-sulfotransferase hst-2
- D-glucuronyl C5-epimerase
- Probable syndecan
- GlyPicaN
- LONg
- Putative extracellular sulfatase Sulf-1 homolog
- Exostosin-like-3 homolog
- WAP-type 'four-disulfide core
- Exostosin-1 homolog
Sequence:
MVKFSTRCVVACLLTIGMCFLQYNLFFRNFKFKWWIDLGKGEKSHLEKKFPSALIVGVRKGGTRALLDAIALHPKVRIVRRETHFFDSNYTLGFDWYRDQMPEVENDNEIVIEKTPAYFTNEHVPKRVYEMNPDMKLILIVRHPVYRTVSDFTQVYYNKLEQNKTLPVLSVEAFKTNEAGIEKINMEYKPMTNSLYDVHISKWLKYFDLKNFLFVNGDVFRANPLRELRKVEEFLGLERSITPSQLVFDYNKGFFCFRKTTKVRCLGLSKGRKHRSVSEDVVAKLSNMFEEHNQNFFRLINRTYSWE
Protein: Delta-9 desaturase-like 4 protein (EC 1.14.19.-) (Q9LMI4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- F20B24.22
- Lysophospholipid acyltransferase LPEAT1
- Heavy metal-associated isoprenylated plant protein 37
- Amino acid transporter AVT1B
- Formate dehydrogenase, chloroplastic/mitochondrial
- Cysteine-rich receptor-like protein kinase 42
- 3-ketoacyl-CoA synthase 8
- Phosphoglycerate mutase family protein
- Fatty acid desaturase 4, chloroplastic
- Small ribosomal subunit protein mS47
Sequence:
MCDPTRDDGSSRSRVVSTMQKRAYFQRQWPLVDVVRASVVVIVHFLCLLAPFNFKWEALRFGLVLFALTTLSITFSFHRNLSHRSFKIPKWLEYPWAYSAVFALQGDPMDWVSIHRFHHQFTDSDRDPHSPKEGLLFSHILWIFDTQYIKYKCGGRDNVLDLKKQWFYKFLRRTIAVHILMFWTILYLYGGLPYLTCGGGVGIFIGYHVTWLVNSACHIWGSRSWNTKDTSRNVWWLSLFTMGESWHNNHHAFESSARQGLEWWQIDITWYLIRLFEVLGIATDVKLPSELQKQKMALVR