wanglab/gogpt-training-data huggingface dataset:
Protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 7.1.1.2) (Q42577)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14671022}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 9
- NADH dehydrogenase iron-sulfur protein 6
- NADH dehydrogenase iron-sulfur protein 2
- NADH-ubiquinone oxidoreductase chain 1
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase iron-sulfur protein 8-B, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
Sequence:
MAMITRNTATRLPLLLQSQRAVAAASVSHLHTSLPALSPSTSPTSYTRPGPPSTSPPPPGLSKAAEFVISKVDDLMNWARTGSIWPMTFGLACCAVEMMHTGAARYDLDRFGIIFRPSPRQSDCMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGLLQLQKKINRRKDFLHWWNK
Protein: Serum amyloid P-component (Agarose-binding protein) (Ss-ABP) (P86693)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000269|PubMed:9639088}.
Interaction partners:
- LOW QUALITY PROTEIN: complement factor H-related protein 5
- Complement factor H-like
- Complement factor H-like
Sequence:
AHQDLSGKVFVIPMATSTSHVKLHARVSEPISAMTM
Protein: Caudal type homeobox 1a (Cdx1a protein) (Homeobox protein CDX-1a) (Homeodomain protein Cdx1a) (Q8AXR4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MSVSYLLDTAMYGNPARHLNLSQPHLNVYPSAPYPDYSGYHPGPALGNDLHHTGSSWSPGFGPGSRDDWPPLYGHGTGHSLPANGVEVSVLPSVDQGLLSGAPVDREEPQDWMRRSAVPTNPGGKTRTKDKYRVVYSDVQRLELEKEFHFSRYITIRRKAELAGTLNLSERQVKIWFQNRRAKERKMNKKRLQQVQQSSSGLANTTTVSSSDSGLMTDNISSSIKEEY
Protein: NADPH oxidase 4 (EC 1.6.3.1) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Q924V1)
Organism: Rattus norvegicus (Rat)
Function: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15322091}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9NPH5}; Multi-pass membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000269|PubMed:14670934}. Nucleus {ECO:0000250|UniProtKB:Q9NPH5}.
Interaction partners:
- Neutrophil cytosolic factor 1
- Cytochrome b-245 light chain
- NADPH oxidase 1
- NADPH oxidase 2
- NADPH oxidase 3
- Dual oxidase 1
- Toll-like receptor 4
- NADPH oxidase organizer 1
- Neutrophil cytosol factor 4
- NADPH oxidase activator 1
Sequence:
MALSWRSWLANEGVKHLCLLVWLSLNVLLFWKTFLLYNQGPEYYYIHQMLGLGLCLSRASASVLNLNCSLILLPMCRTVLAYLRGSQKVPSRRTRRLLDKSKTLHITCGITICIFSGVHVAAHLVNALNFSVNYSEHFLALNAARYQNEDPRKLLFTTVPGLTGVCMVVVLFLMVTASTYAIRVSNYDIFWYTHNLFFVFYMLLLLHVSGGLLKYQTNLDTHPPGCISLNRTPSQNMSIADYVSEHFHGSLPGGFSKLEDHYQKTLVKICLEEPKFQAHFPQTWIWISGPLCLYCAERLYRCIRSNKPVTIISVINHPSDVMELRMIKENFKARPGQYIILHCPSVSALENHPFTLTMCPTETKATFGVHFKVVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFQWFADLLYVLHNKFWQENRPDFVNIQLYLSQTDGIQKIIGEKYHTLNSRLFIGRPRWKLLFDEIAKCNRGKTVGVFCCGPSSISKTLHNLSNRNNSYGTKFEYNKESFS
Protein: CLN6 transmembrane ER protein (A0A1B0GTU6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEATRRRQHLGATGGPGAQLGASFLQARHGSVSADEAARTAPFHLDLWFYFTLQNWVLDFGRPIAMLIERSPRTLPRSITYVSIIIFIMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCMWYIPFFLILFMYFSGCFTASKAESLIPGPALLLVAPSGLYYWYLVTEGQIFILFIFTFFAMLALVLHQKRKRLFLDSNGLFLFSSFALTLLLVALWVAWLWNDP
Protein: Uncharacterized protein C1739.04c (O74466)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Sporulation-specific protein 15
- Meiotically up-regulated gene 165 protein
- Meiotically up-regulated gene 123 protein
- Meiotically up-regulated gene 168 protein
Sequence:
MNSVPNELTKSQELFGQISKISHSKISISELITLLDIHYSELFTKNPWMKKEVRKLASEFVENDPNHLLSKQDACHLIEAFVNVSITSPTLLTSVDPVLYQQLEASSTNDISTVFEDESSSLPIILHPKFSSMQVRTVTSPKDAFVSAFEENKFHFAATESFFEMAFSKIDSCLTSVQSTKKDSIKSRLVERYIQNEESVKRPDKSPFDTMTEATLQSSSDKSENFTKTLLSNVLSTILSVQVIFATVIALIAISVFCFLHTSSKTTSSKTRPS
Protein: Centromere DNA-binding protein complex CBF3 subunit A (Centromere-binding factor 2) (Chromosome transmission fidelity protein 14) (Kinetochore protein CTF14) (P32504)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters.
Subcellular location: Nucleus {ECO:0000269|PubMed:10427094}. Chromosome, centromere {ECO:0000269|PubMed:10427094}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:10427094}. Note=Spindle midzone during anaphase B.
Interaction partners:
- Suppressor of kinetochore protein 1
- Centromere DNA-binding protein complex CBF3 subunit C
- Centromere DNA-binding protein complex CBF3 subunit B
- Histone H3-like centromeric protein CSE4
- Centromere-binding protein 1
- Chromosomal passenger complex protein BIR1
- SUMO-conjugating enzyme UBC9
- Protein SCM3
- Aurora kinase
- Transcription elongation factor SPT6
Sequence:
MRSSILFLLKLMKIMDVQQQQEAMSSEDRFQELVDSLKPRTAHQYKTYYTKYIQWCQLNQIIPTPEDNSVNSVPYKDLPISAELIHWFLLDTLITDDKPGEKREETEDLDEEEENSFKIATLKKIIGSLNFLSKLCKVHENPNANIDTKYLESVTKLHTHWIDSQKAITTNETNNTNTQVLCPPLLKVSLNLWNPETNHLSEKFFKTCSEKLRFLVDFQLRSYLNLSFEERSKIRFGSLKLGKRDRDAIIYHKVTHSAEKKDTPGHHQLLALLPQDCPFICPQTTLAAYLYLRFYGIPSVSKGDGFPNLNADENGSLLQDIPILRGKSLTTYPREETFSNYYTTVFRYCHLPYKRREYFNKCNLVYPTWDEDTFRTFFNEENHGNWLEQPEAFAFPDKIPFDFKKIMNFKSPYTSYSTNAKKDPFPPPKDLLVQIFPEIDEYKRHDYEGLSQNSRDFLDLMEVLRERFLSNLPWIYKFFPNHDIFQDPIFGNSDFQSYFNDKTIHSKGSPILSFDILPGFNKIYKNKTNFYSLLIERPSQLTFASSHNPDTHPTQKQESEGPLQMSQLDTTQLNELLKQQSFEYVQFQTLSNFQILLSVFNKIFEKLEMKKSSRGYILHQLNLFKITLDERIKKSKIDDADKFIRDNQPIKKEENIVNEDGPNTSRRTKRPKQIRLLSIADSSDESSTEDSNVFKKDGESIEDGAYGENEDENDSEMQEQLKSMINELINSKISTFLRDQMDQFELKINALLDKILEEKVTRIIEQKLGSHTGKFSTLKRPQLYMTEEHNVGFDMEVPKKLRTSGKYAETVKDNDDHQAMSTTASPSPEQDQEAKSYTDEQEFMLDKSIDSIEGIILEWFTPNAKYANQCVHSMNKSGNKSWRANCEALYKERKSIVEFYIYLVNHESLDRYKAVDICEKLRDQNEGSFSRLAKFLRKWRHDHQNSFDGLLVYLSN
Protein: Ran GTPase-activating protein 2 (Ran nuclear import/export-related protein 2) (RanGAP) (P34342)
Organism: Caenorhabditis elegans
Function: GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate.
Subcellular location: Nucleus {ECO:0000269|PubMed:11909538}.
Interaction partners:
- Nuclear Pore complex Protein
- GTP-binding nuclear protein ran-1
- Small ubiquitin-related modifier
- SUMO-conjugating enzyme UBC9
- Regulator of chromosome condensation
- Importin N-terminal domain-containing protein
- Sentrin-specific protease
- Thrombospondin type 1 domain protein
- Importin N-terminal domain-containing protein
- Nuclear pore complex protein 15
Sequence:
MLPRLFLTILPVCSPSISNKTSKKFRDAHANHVFLFEMDLNNTLSFFGKQLKLDTEEEISKVIDQIRKHLNLEVLDFRGNTLSVLAGKLIAESLKTRRELKECIWSDMFTGRLKDEIPLVLDALGEALTASGCRLTTLDLSDNAFGAGLSTSLYNFLQSPALYSLENLILNNNGLGLAGKTVGKALCSLIDASKKAGTPLKLKKFVCGRNRLEVESTIALSDAFIKLGTLEEIRLPQNGIRDDGIIALAEAFRMNKKLRIIDINDNFCCPEGAIQISEVLSDLQFIEVLDLGDCVCDDPGVLAIIAELDKINRDCLKKVVLSGNNITSDVIDEIGACFNSPKMCHVKVDISVNMFGKDFDSAKARHGKGNIDFGRRGDDELLSSDEEEEQGAEDASMEEDAFNTSRETVIDRSNLHEASADEMMNDLMNKGFGCMKIEDNQQNSNGNGMVSFLDKSLKLDTAESAEPVVKVIAAASSMKALELRGNTLGIAAGNVIAKALESHPELERCLWSDLFTGRLKNEIPPILEALGKAMMTAGCKIKELDLSDNAFGPIGADALKDLLESPSSFSLEVLKLNNNGLGIGGKQIAKSLTECLRKSIAVGGENRLRLKTFIAGRNRLENPGAHALAATFKALETVEWFDVRQNGIHEEGIRALVAALKHNRNLRYLWLEDNTVLPKGAKALAKTLESWPKLEVLNLSDCLIRDAGCNYIIDHLNPQHHRHLKNVYLCGNELTPPVAKLLIQKWSKFDGLTPKPVLHIHTNSFGDEFSDVAGMAPENVNVGDEDDDLGSLDGDQEEYNSKSSDSEDADLDDDDEDDDEEAEIQIIDNGESQLKLAMDRIDRLDIDFESRFQEDTARVILQLSAPLKSCKMSEPALQRAIEVAENIVRRVESVKRNPIPATTQLVNNIVAQCAGTGVKAETDWGYGADPQVISRLFSELVARGHFKLELALLQRFFPSQ
Protein: Rho GTPase activating protein at 18B, isoform D (RhoGAP18B-PD) (Q00IN0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAAPKPNGEAERPSTNSNNNTINCSSNNNNDNISNNNNNHHTVDNESGINNNKNNDGNANCNVNEQQQQQQQQPITQNCVIKVRRPAPKVPVRNPNTSLSNPRQIEEEQTKPNGGKKDNLRGNSFAAENSSPEEQEEESIYQPIWQFKTIEPVDQEIIEALPVEGEDEEDEDEEDDDVDDEEEDLGDYDESLPSDADPDVMALQAAAVFAAGVRHKLSTSTLTKRSKMMMPTPLPSPTASMDHGAWETDMEFMYSRESKEEADETLSLGSTVTNSTATLGSISSTGSSVTGQPKDTPKDLPADQQPSVVVHPILRNICIFYSQKDPKKYSAIFYDYHLSLVHQRFMTRIRRPAPPPPAQLATSNTTSLAPRSDDSGCSCEAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRGVAPRTGRKLRVRSNARLLLTDSVLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTILQRYKSVSIGNLLDLPGEDDKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRSRRGQVNSLYLDEQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQLDIGRMNMLAKVLIENYDRIFHPDNERLVC
Protein: Pyridoxal dependent decarboxylase domain containing 1 (J3KNK7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVSILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSDTTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPGPWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHACQLSQRLQKV
Protein: Projectin (Q24463)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
VKAINAAGPGEPSDASKPIITKPRKLAPKILDPTKNIRTYNFKSGEPIFLDINISGEPAPDVTWNQNNKSVQTTSFSHIENLPYNTKYINNNPERKDTGLYKISAHNFYGQDQVEFQINIITKPGKPGGPLEVSEVHKDGCKLKWKKPKDDGGEPVESYLVEKFDPDTGIWLPVGRSDGPEYNVDGLVPGHDYKFRVKAVNKEGESEPLETLGSIIAKDPFSVPTKPGVPEPTDWTRNKVELAWPEPASDGGSPIQGYIVEVKDKYSPLWEKALETNSPTPTATVQGLIEGNEYQFRVVALNKGGLSEPSDPSKIFTAKPRYLAPKIDRRNLRNITLSSGTALKLDANITGEPAPKVEWKLSNYHLQSGKNVTIETPDYYTKLVIRPTQRSDSGEYLVTATNTSGKDSVLVNVVITDKPSPPNGPLQISDVHKEGCHLKWKAPSDDGGTPIEYFQIDKLEPETGCWIPSCRSTEPQVDVTGLSPGNEYKFRVSAVNAEGESQPLVGDESIVARNPFDEPGKPENLKATDWDKDHVDLAWTPPLIDGGSPISCYIIEKQDKYGKWERALDVPADQCKATIPDLVEGQTYKFRVSAVNAAGTGEPSDSTPPIIAKARNKPPIIDRSSLVEVRIKAGQSFTFDCKVSGEPAPQTKWLLKKKEVYSKDNVKVTNVDYNTKLKVNSATRSDSGIYTVFRENANGEDSADVKVTVIDKPAPPNGPLKVDEINSESCTLHWNPPDDDGGQPIDNYVVGKLDETTGRWMTAGETDGPVTALKVGGLTPGHKYKFRVRAKNAQGTSEPLTTAQAIIAKNPFDVPTKPGTPTIKDFDKEFVDLEWTRPEADGGSPITGYVVEKRDKFSPDWEKCAEISDDITNAHVPDLIEGLKYEFRVRAVNKAGPGSPSDATETHVARPKNTPPKIDRNFMSDIKIKAGNVFEFDVPVTGEPLPSKDWTHEGNMIINTDRVKISNFDDRTKIRILDATSDTGVYTLTARNINGTDRHNVKVTILDAPSVPEPALRNGDVSKNSIVLRWRPPKDDGGSEITHYVVEKMDNEAMRWVPVGDCTDTEIRADNLIENHDYSFRVRAVNKQGQSQPLTTSQPITAKDPYSHPDKPGQPQATDWGKHFVDLEWSTPKRDGGAPISSYIIEKRPKFGQWERAAVVLGDNCKAHVPELTNGGEYEFRVIAVNRGGPSDPSDPSSTIICKPRFLAPFFDKSLLNDITVHAGKRLGWTLPIEASPRPLITWLYNGKEIGSNSRGESGLFQNELTFEIVSSLRSDEGRYTLILKNEHGSFDASAHATVLDRPSPPKGPLDITKITRDGCHLTWNVPDDDGGSPILHYIIEKMDLSRSTWSDAGMSTHIVHDVTRLVHRKEYLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKPIITDWDRDHIDLQWAVPKSDGGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQAGQSEPSEPSDMIMRKPRYLPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATWTLNSNPLLSNDRSTITSIGHHSVVHTVNCQRSDSGIYHLLLRNSSGIDEGSFELVVLDRPGPPEGPMEYEEITANSVTISWKPPKDNGGSEISSYVIEKRDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSDPLTSDQPVVAKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSCRVDLQACKLGT
Protein: Transmembrane p24 trafficking protein 2 (E7EQ72)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004151}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004151}. Golgi apparatus, cis-Golgi network membrane {ECO:0000256|ARBA:ARBA00004619}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004619}. Membrane {ECO:0000256|RuleBase:RU003827}; Single-pass type I membrane protein {ECO:0000256|RuleBase:RU003827}.
Interaction partners:
Sequence:
MVTLAELLVLLAALLATVSGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEGGGDTWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHR
Protein: Actin-related protein 2/3 complex subunit 5A (Actin-related protein C5A) (Arp2/3 complex 16 kDa subunit) (p16-ARC) (Protein CROOKED) (Q9M117)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2A
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 2B
- Actin-related protein 2/3 complex subunit 1A
- Actin-related protein 2
- Actin-related protein 3
- At4g14145
- Uncharacterized protein
Sequence:
MAEFVEADNAEAIIARIETKSRKIESLLKQYKHVEALKTALEGSPPKTRDERCKSANWIVVHRALMAIKDIDGMLNALDVEYYDILMKYLYRGLSTGDRPTCDQCLKIHEKLTERAGLGCILRCLTDTINTV
Protein: Transcription factor SOX-12 (Protein SOX-22) (O15370)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (By similarity). Acts as a transcriptional activator (By similarity). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (By similarity). Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (By similarity). Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:9215677}.
Interaction partners:
- Glycogen [starch] synthase, muscle
- Glycogenin-1
Sequence:
MVQQRGARAKRDGGPPPPGPGPAEEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGSGGGSRLKPGPQLPGRGGRRAAGGPLGGGAAAPEDDDEDDDEELLEVRLVETPGRELWRMVPAGRAARGQAERAQGPSGEGAAAAAAASPTPSEDEEPEEEEEEAAAAEEGEEETVASGEESLGFLSRLPPGPAGLDCSALDRDPDLQPPSGTSHFEFPDYCTPEVTEMIAGDWRPSSIADLVFTY
Protein: Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Q8R3L8)
Organism: Mus musculus (Mouse)
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 13
- Cyclin-C
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 13-like
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 17
Sequence:
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDEKGDKKTQQQQQGNNHTNGTGHPGNQDSGHAQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
Protein: E3 ubiquitin-protein ligase TRIM62 (EC 2.3.2.27) (Tripartite motif-containing protein 62) (Q80V85)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BVG3}.
Interaction partners:
- Caspase recruitment domain-containing protein 9
Sequence:
MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSAFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFEELQRELKEQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTMDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
Protein: Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Protein kinase p42 KKIALRE) (Serine/threonine-protein kinase KKIALRE) (Q00532)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9000130}. Nucleus {ECO:0000269|PubMed:9000130}.
Interaction partners:
- Cyclin-dependent kinase-like 4
Sequence:
MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI
Protein: Large ribosomal subunit protein uL13y (60S ribosomal protein L13a-2) (Q9LRX8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL13z
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL24z
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein uL4y
Sequence:
MVSGSGICSKRVVVDARHHMCGRLASIIAKELLNGQSVVVVRCEEICLSGGLVRQKMKYMRFLRKRMNTKPSHGPIHFRAPSKIFWRTVRGMIPHKTKRGAAALARLKVFEGVPPPYDKVKRMVIPDALKVLRLQAGHKYCLLGRLSSEVGWNHYDTIKELEVKRKERSQALYERKKQLTKLRAKAEKVAEEKLGSQLDVLASIKY
Protein: Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein) (Q8WTT2)
Organism: Homo sapiens (Human)
Function: May be required for adipogenesis.
Subcellular location: Nucleus, nucleolus. Nucleus speckle.
Interaction partners:
- Nucleolar complex protein 2 homolog
- Ribosome biogenesis protein BRX1 homolog
- Protein MAK16 homolog
- Ribosome biogenesis protein BOP1
- MKI67 FHA domain-interacting nucleolar phosphoprotein
- GTP-binding protein 4
- Ribosome biogenesis protein WDR12
- Probable rRNA-processing protein EBP2
- Pescadillo homolog
- Ribosomal L1 domain-containing protein 1
Sequence:
MKARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKRIEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELIHLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAILSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEGLVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSKLISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTFKEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLKLHTETLNIVFVTYFRILKKAQRSPLLPAVLEGLAKFAHLINVEFFDDLLVVLHTLIESGDLSYQESLHCVQTAFHILSGQGDVLNIDPLKFYTHLYKTLFKLHAGATNEGVEIVLQCLDVMLTKRRKQVSQQRALAFIKRLCTLALHVLPNSSIGILATTRILMHTFPKTDLLLDSESQGSGVFLPELDEPEYCNAQNTALWELHALRRHYHPIVQRFAAHLIAGAPSEGSGALKPELSRRSATELFEAYSMAEMTFNPPVESSNPKIKGKFLQGDSFLNEDLNQLIKRYSSEVATESPLDFTKYLKTSLH
Protein: Achromobactin siderophore NIS synthase (E0SIF5)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Interaction partners:
- Achromobactin siderophore NIS synthase
- Putative AcsD
- Diaminopimelate decarboxylase
- 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase
- Inner membrane component of tripartite multidrug resistance system
- Achromobactin-binding periplasmic protein
Sequence:
MEGNVMDSNAMKTTSHYKDAGHCVMQDLVDCLLAEEFFGPQLLALYTPDEWRQQYGQPAPFGALDSAARLWRWCSDEREQRHLVVALRPGITQRWEKVPDTLVYAWQQGGNDWRELEPESFMNLVFAGQHGEEGNAGDNNAAENNAKGQALFLDVLNTSVEQTALSREHRIDTDNLLARGNADFFHVMEQWASLRDRPFHPTAKAKQGLNAEEYRRYVAEFAEPVALNWVAVAKDRLQCGDGISATADQYPAGYLLPQAEQVALQQELAARGIADTHIALPVHPWQFDHILETQLGDAFRNGDCHRLDFSAARYLPTSSLRSMTPCFASADYLKLPMAVYSLGASRYLPAVKMINGGLSEALLRQARDKDTVLQERLYLCDEGKWWAFMPPQATLFDEAPRHLSAMVRSYPSALLDDPDYRLMPMAALGTPLPGSRRHFFDDWLAYRGLPTNADSVLTLFAELCHCFFDINFRMFRLGMLGEIHGQNAVLVWKAGQAHGLLLRDHDSLRIHVPTLEQNGMQDPVYRIKKGHANTLYHERLDDLLFWLQTLGIQVNMRAIIETLSLTYEVEAATLWGVMRREINGAIDRAGFAADTQAMLKTRLFDAPNWPQKLLITPMIARAGGPGSMPFGKGEVINPFQSVIVNKQ