wanglab/gogpt-training-data huggingface dataset:
Protein: Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) (P16068)
Organism: Bos taurus (Bovine)
Function: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7908439}.
Interaction partners:
- Guanylate cyclase soluble subunit alpha-1
- Guanylate cyclase soluble subunit alpha-2
- cGMP-dependent protein kinase
- cGMP-dependent protein kinase 1
- Inosine triphosphate pyrophosphatase
- Nitric oxide synthase 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Pyruvate kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Pyruvate kinase
Sequence:
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDADKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKSECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMTPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETEQDEN
Protein: Serpentine Receptor, class H (Q9GS03)
Organism: Caenorhabditis elegans
Interaction partners:
- Serpentine Receptor, class H
- MEF2 transcription factor homolog
- Serpentine receptor class r-10
Sequence:
MIACNNHYLGSPDFLKMTFHVITGLATPIHAFGFYCIVKKTPIHMKPVKWLLFNMHCWCILLDITISFLGIPYIIFPAMAGWGLGPIESPGLFFYLGVTFITGVTTSVFVTFENRFFLLFGERTFWIHLRKYAIVASYVIVPLYYLPVQFVLPDQEIGREFSWTLLECMPELPSDGRPLFVLATDITAPAIGIGVSCFVPTVQCGSFLTLNIYNLIFARPSGISKRTIEMQHKLVIALIVQSSVTFVLFIVPVQCIVTFVYFHHQNQFHNNLIFFALAIHGIASTLIMIFAHKPYRDFVLSPIYRFTERTLIVAVAPSVFPTNSFSGAARNQAS
Protein: Mannosylglycerate synthase (EC 2.4.1.269) (D8S5L4)
Organism: Selaginella moellendorffii (Spikemoss)
Function: Involved in the biosynthesis of the compatible solute alpha-D-mannosyl-glycerate (MG). Catalyzes the condensation of GDP-alpha-D-mannose (GDP-Man) with D-glycerate to produce alpha-D-mannosyl-glycerate. Can also use GDP-alpha-D-glucose (GDP-Glc) as sugar donor to produce alpha-D-glucopyranosyl-glycerate (GG).
Interaction partners:
Sequence:
MSLVCFPFKEEDVAVVVRNVECAAAHPRVSTVLCVGYSKGETWCAIEAKRPSIESSTGKRIILLQQKRIGVSLRSGKGDGMNTALAYFLDHTELKRIHFYDSDIVSFSADWITKAERQADLDFDVVRHYFPRSSTDAMITWFVTKIGFCLLWPKTVLPFIEQPLGGELLLTRKAAEALYTDHRVRGQSDWGIDTLYTFIMVQKGLHLAEVYIPEGKVHALYSGLRDLRTMLVECFSAMQSLKDEAVPLNEGTHRMEYTRPVPELVKQKVGYDVEKTLKLLRSNWTQGQRDLLQKHFDPALAKGLLNASEWPTWGFADEEAWVAAYRTLLVHFEKGDEDWEELLFKIWVSRVLNHTMRHSLRGYDAALDALRSLIWETQHQSAMLSKSAAANHHIVSGHSASEALPRTAGQLREKRMDAACAV
Protein: Chlorophyll(ide) b reductase NOL, chloroplastic (EC 1.1.1.294) (Protein NON-YELLOW COLORING 1-LIKE) (AtNOL) (Protein NYC1-LIKE) (Short-chain dehydrogenase/reductase NOL) (Q8LEU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for chlorophyll b degradation. Chlorophyll b, chlorophyllide b, pheophorbide b and pheophytin b can be used as substrates. Belongs to the chlorophyll catabolic enzymes (CCEs).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:22366162}; Peripheral membrane protein {ECO:0000269|PubMed:22366162}.
Interaction partners:
- 7-hydroxymethyl chlorophyll a reductase, chloroplastic
- Chlorophyllide a oxygenase, chloroplastic
- Chlorophyll synthase, chloroplastic
- Chlorophyllase-1
- Chlorophyllase-2
- Probable chlorophyll
- Pheophytinase, chloroplastic
- Pheophorbide a oxygenase, chloroplastic
- Red chlorophyll catabolite reductase, chloroplastic
- Magnesium dechelatase SGR1, chloroplastic
Sequence:
MATWSGFNVSSSPLLRLRSSSVSNVTKLPFLSPICRRRLLAERFGLATVVVTRQNLTVTPSSAAVEARISGKREPMTPPYNILITGSTKGIGYALAREFLKAGDNVVICSRSAERVETAVQSLKEEFGEHVWGTKCDVTEGKDVRELVAYSQKNLKYIDIWINNAGSNAYSFKPLAEASDEDLIEVVKTNTLGLMLCCREAMNMMLTQSRGGHIFNIDGAGSDGRPTPRFAAYGATKRSVVHLTKSLQAELQMQDVKNVVVHNLSPGMVTTDLLMSGATTKQAKFFINVLAEPAEVVAEYLVPNIRAIPASGSMKPTYIRFLTGIKAYTKIFSRVALGARKNRYVTEE
Protein: Ubiquitin domain-containing protein UBFD1 (Ubiquitin-binding protein homolog) (O14562)
Organism: Homo sapiens (Human)
Function: May play a role as NF-kappa-B regulator.
Interaction partners:
- 26S proteasome regulatory subunit 6B
- 26S proteasome non-ATPase regulatory subunit 6
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome non-ATPase regulatory subunit 2
- 26S proteasome non-ATPase regulatory subunit 11
- 26S proteasome non-ATPase regulatory subunit 3
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome non-ATPase regulatory subunit 1
- 26S proteasome regulatory subunit 7
Sequence:
MAAAGAPDGMEEPGMDTEAETVATEAPARPVNCLEAEAAAGAAAEDSGAARGSLQPAPAQPPGDPAAQASVSNGEDAGGGAGRELVDLKIIWNKTKHDVKFPLDSTGSELKQKIHSITGLPPAMQKVMYKGLVPEDKTLREIKVTSGAKIMVVGSTINDVLAVNTPKDAAQQDAKAEENKKEPLCRQKQHRKVLDKGKPEDVMPSVKGAQERLPTVPLSGMYNKSGGKVRLTFKLEQDQLWIGTKERTEKLPMGSIKNVVSEPIEGHEDYHMMAFQLGPTEASYYWVYWVPTQYVDAIKDTVLGKWQYF
Protein: WD repeat-containing protein 72 (D3YYM4)
Organism: Mus musculus (Mouse)
Function: Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:25008349}.
Interaction partners:
- Protein FAM83H
- Matrix metalloproteinase-20
- Enamelin
- Kallikrein-4
- Pseudokinase FAM20A
- Amelogenin, X isoform
- Kallikrein 1-related peptidase-like b4
- Sodium/potassium/calcium exchanger 4
Sequence:
MRGALQAVALWGRKAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSPELKISAKELLFGHSASVTCLARARDFSKQPYVVSAAENGEMCMWNVSSGQCVEKTSLPYRHTAICYYHCSFRMTGEGWLLCCGEYQDVLVLDAGTLAVLHTFTSLQSPDWMKCMCIVHSVRIQEDSLLVVSITGELKVWDLSSSINSIQEKQDVHEKESKFLDSFNCQTIRFCPYTERLLLVVFSKCWKIYDYCDFSLLWTEVSRDGQFFAGGEVLAAHRILVWTEDGHSYIYQLLNRWAQMGATLRTFSGLSKCVCPADGGVLKGTVYPHLLCSTSVEENKSLHFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPISKFDGSPREIPITTTWTLQDNFDKHQMVSQSITDHFSGSRDEVGMTATITSSEYIPNLDKLICGCEDGTIFITKALNAAKAGLLEGDSLLKDSPCHTLLRGHHQSVTSLLYPHNLASKLDQSWMVSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPENLKRSDGQILCCVCGDHSVALLHLEGRRCLLRARKHLFPVRMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETGERARIILNCGDDAQLIRSEPTLSVASETHKHKSIEQKSSNSHQPGPVPCPSVQLESSCKVADASSVPRPFNVLPVKTKWSHIGFHVLLFDLENLVELLLPTPLSDVDPSGSFYGGDILRRAKSTVEKKTLTIRRNKASCSSLQTEAQAKPSGDSLVLGDSTSKFSEENNGIKRQKKMKSSKKAHPKPPRKVDASLTIDMAKLFLSCILPWGVDKDLDSLCTRHLSILKLQGPVSLGLASNEDLFSLMLPGWDACSTEMKEYSGVNLCSRKVLDLSSKYTATLLHQTGIPRGLESHCDSVQQSDAIVYLLSRLFLVNKLVNMPLDLACEIDRPFKMETVHSKARFPGSDILNISSFYGHPKNGGNECRAPEADLSLLKLISCWRDQSVQVTEAIQAVLLAEVQQHMKSLRNTPVSSQPDPVAEHSICERMQISAKMEWTEELELQYVGKSSPLKTSVSPVKHGNDLNSANFQDTEDILDRCVLEESESAGQPRHRPWIAKVCSCRMC
Protein: Kinetoplastid kinetochore protein 11 (Q57V00)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTRPRLTSAPRGSALKEAISAHQALRNAVAQEQSALDDELKKNEQILAEHEQLMRDWSCDKEGVLATIQKMKEKIAENESKTTEARAEVKQNEEIVKRLHARNEEYEPRLEASAIEIAERLKKREEEEKEMREQLLTFQIACQEREQQYRDQIHKLEETNAQEAVDHQQKVQQLRSKIAEVEATMEEERRAWVVETEMRKQQRLIERHKFFTEEAEEARKGKEACAAIMKEASALRMDSNLLTSLDDLLCC
Protein: G-protein coupled receptor 12 (GPCR01) (P35412)
Organism: Mus musculus (Mouse)
Function: Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production (By similarity). Promotes neurite outgrowth and blocks myelin inhibition in neurons.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MNEDPKVNLSGLPRDCIDAGAPENISAAVPSQGSVAESEPELVVNPWDIVLCSSGTLICCENAVVVLIIFHSPSLRAPMFLLIGSLALADLLAGLGLIINFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSISFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLALILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLSQRARSPSDV
Protein: Type III secretion system effector VopR (Q87P35)
Organism: Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Interaction partners:
Sequence:
MVNINTSHMQSLSQLTSHLATQNQADDKEIRAHNGKDIFVKEGAPKNKSVSARISHQNKAKDIVVNLLTKQGIPKDVAKQMLQNVLNGENKLTLGNLKNLERLSSGPSSHWPAAQTDTSSSKTSKASSSVALINEHKDNLQKLGDFACTDLNTFGQKGSQFYETKGAPRLKALYANQARIAQDQRATMSASAVQAAAQRGNAPQLSTLQNIAKYVQNAKAGCCTTFAFAAAAEMIQGMSGTPENQPKVEVVAFKKGHSGTHLYVLVGRQEGSDIKDPSTWNKDVKIVDPWAASAFGATMFGDAQRPPVSNMFPPTEVIFDSHKLG
Protein: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) (Q75WV4)
Organism: Nicotiana tabacum (Common tobacco)
Interaction partners:
Sequence:
RWSYDVFLSFRGEDTRKTFTSHLYEVLNDKGIKTFQDDKRLEYGATIPGELCKAIEESQFAIVVFSENYATSRWCLNELVKIMECKTRFKQTVIPIFYDVDPSHVRNQKESFAKAFEEHETKYKDDVEGIQRWRIALNEAANLKGSCDNRDKTDADCIRQIVDQISSKLCKISLSYLQNIVGIDTHLEKIESLLEIGINGVRIMGIWGMGGVGKTTIARAIFDTLLGRMDSSYQFDGACFLKDIKENKRGMHSLQNALLSELLREKANYNNEEDGKHQMASRLRSKKVLIVLDDIDNKDHYLEYLAGDLDWFGNGSRIIITTRDKHLIEKNDIIYEVTALPDHESIQLFKQHAFGKEVPNENFEKLSLEVVNYAKGLPLALKVWGSLLHNLRLTEWKSAIEHMKNNSYSGIIDKLKISYDGLEPKQQEMFLDIACFLRGEEKDYILQILESCHIGAEYGLRILIDKSLVFISEYNQVQMHDLIQDMGKYIVNFQKDPGERSRLWLAKEVEEVMSNNTGTMAMEAIWVSSYSSTLRFSNQAVKNMKRLRVFNMGRSSTHYAIDYLPNNLRCFVCTNYPWESFPSTFELKMLVHLQLRHNSLRHLWTETKHLPSLRRIDLSWSKRLTRTPDFTGMPNLEYVNLYQCSNLEEVHHSLGCCSKVIGLYLNDCKSLKRFPCVNVESLEYLGLRSCDSLEKLPEIYGRMKPEIQIHMQGSGIRELPSSIFQYKTHVTKLLLWNMKNLVALPSSICRLKSLVSLSVSGCSKLESLPEEIGDLDNLRVFDASDTLILRPPSSIIRLNKLIILMFRGFKDGVHFEFPPVAEGLHSLEYLNLSYCNLIDGGLPEDIGSLSSLKKLDLSRNNFEHLPSSIAQLGALQSLDLKDCQRLTQLPELPPELNELHVDCHMALKFIHDLVTKRKKLHRVKLDDAHNDTMYNLFAYTMFQNISSMRHDISASDSLSLTVFTGQPYPEKIPSWFHHQGWDSSVSVNLPENWYIPDKFLGFAVCYSRSLIDTTAHLIPVCDDKMSRMTQKLALSECDTESSNYSEWDIHFFFVPFAGLWDTSKANGKTPNDYGIIRLSFSGEEKMYGLRLLYKEGPEVNALLQMRENSNEPTEHSTGIRRTQYNNRT
Protein: UPF0182 protein Rv3193c (P9WFL3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
Interaction partners:
- Probable mycobacterial cidal antitoxin Rv3188
- endopeptidase La
- Lipoprotein LprN
- Putative transposase Rv3428c
Sequence:
MGMRSAARMPKLTRRSRILIMIALGVIVLLLAGPRLIDAYVDWLWFGELGYRSVFTTMLATRIVVCLVAGVVVGGIVFGGLALAYRTRPVFVPDADNDPVARYRAVVLARLRLVGIGIPAAIGLLAGIVAQSYWARIQLFLHGGDFGVRDPQFGRDLGFYAFELPFYRLMLSYMLVSVFLAFVANLVAHYIFGGIRLSGRTGALSRSARVQLVSLVGVLVLLKAVAYWLDRYELLSHTRGGKPFTGAGYTDINAVLPAKLILMAIALICAAAVFSAIALRDLRIPAIGLVLLLLSSLIVGAGWPLIVEQISVKPNAAQKESEYISRSITATRQAYGLTSDVVTYRNYSGDSPATAQQVAADRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFPDQLSIDRYLDRNGNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGFIASPANTVRGIANDPNQNGGYPEFLVNVVGANGTVVSDGPAPLDQPRIYFGPVISNTSADYAIVGRNGDDREYDYETNIDTKRYTYTGSGGVPLGGWLARSVFAAKFAERNFLFSNVIGSNSKILFNRDPAQRVEAVAPWLTTDSAVYPAIVNKRLVWIVDGYTTLDNYPYSELTSLSSATADSNEVAFNRLVPDKKVSYIRNSVKATVDAYDGTVTLYQQDEKDPVLKAWMQVFPGTVKPKSDIAPELAEHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPTASSYQPPYYIVAKNIAKDDNSASYQLISAMNRFKRDYLAAYISASSDPATYGNLTVLTIPGQVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGNLLTLPVARGGLLYVEPVYASPGASDAASSYPRLIRVAMMYNDKVGYGPTVRDALTGLFGPGAGATATGIAPTEAAVPPSPAANPPPPASGPQPPPVTAAPPVPVGAVTLSPAKVAALQEIQAAIGAARDAQKKGDFAAYGSALQRLDEAITKFNDAG
Protein: F-box and WD repeat domain-containing 11-B (A0A2R8RWN9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Participates in Wnt signaling regulation, and plays a role in eye and jaw development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q5SRY7}. Nucleus {ECO:0000250|UniProtKB:Q5SRY7}.
Interaction partners:
Sequence:
MFDLKQTLLLISELMHLFLLRLQNTSVMDPQTADRSPKITLIKVSNGPLTGSRKRPSEGNYEKEKDVCIQLFDQWSEADQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPAQGLDHIAENILSFLDARSLCSAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERHQWEKYLFKNRTTEVPPNSYYRSLYPKIIQDIETIEANWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKQTLECLKILTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNSGEVLNTLIHHNEAVLHLRFCNGLMVTCSKDRSIAVWDMASPTDISLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVSTNGQTEGRSPSRTYTYISR
Protein: Complexin-3 (Complexin III) (CPX III) (Q8R1B5)
Organism: Mus musculus (Mouse)
Function: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion. Required for the maintenance of synaptic ultrastructure in the adult retina. Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina. Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release.
Subcellular location: Synapse {ECO:0000269|PubMed:15911881, ECO:0000269|PubMed:22694764}. Cell membrane {ECO:0000269|PubMed:15911881}; Lipid-anchor {ECO:0000269|PubMed:15911881}. Note=Enriched at the synaptic terminal (PubMed:15911881). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (PubMed:22694764). {ECO:0000269|PubMed:15911881, ECO:0000269|PubMed:22694764}.
Interaction partners:
- Syntaxin-1A
- Synaptosomal-associated protein 25
- Complexin-1
- Vesicle-associated membrane protein 2
- Vesicle-associated membrane protein 1
Sequence:
MAFMVKSMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDAQFTQRKAERATLRSHFRDKYRLPKNETDESQIQLAGGDVELPRELAKMIEEDTEEEEDKASVLGQLASLPGLDLSSLKDKAQTTLGDLKQSAEKCHIM
Protein: isocitrate dehydrogenase (NAD(+)) (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD(+)-specific ICDH) (Q6FQD0)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Isocitrate dehydrogenase subunit 1, mitochondrial
- Aconitate hydratase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase
- Isocitrate dehydrogenase
- Isocitrate dehydrogenase
- dihydrolipoyllysine-residue succinyltransferase
- Glutamate synthase
- Dihydrolipoyl dehydrogenase
- NAD-specific glutamate dehydrogenase
Sequence:
MLGIRSFRLNARRFLATAQPSIGRFTGKPNPSTGKFTVSFIEGDGIGPEISSSVKRIFQAADVPVEWETCDVTPIFVNGLTTIPDPAVQSINKNLVALKGPLATPIGKGHRSLNLTLRKTFNLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHLVSPGVVQSIKLITRDASERVIRYAYEYARAIGRPRLIVVHKSTIQRLADGLFVNVAKELAAEYPDIQLETELIDNTCLNVVSNPSSYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNHMGMTEHADRIEKAVLGTIAGGSEYRTGDLGGSASTTSFTDAIIKKL
Protein: Ribonuclease VapC11 (RNase VapC11) (EC 3.1.-.-) (Toxin VapC11) (P9WFA5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in E.coli and M.smegmatis inhibits translation, cell growth and colony formation. Its toxic effects on cell growth and colony formation are neutralized by coexpression with cognate antitoxin VapB11; the effect on translation has not been tested but is probably also neutralized.
Interaction partners:
- Antitoxin VapB11
- Antitoxin VapB15
- Ribonuclease VapC26
- Ribonuclease VapC29
- Ribonuclease VapC32
- Ribonuclease VapC30
- Possible hydrolase
- 23S rRNA-specific endonuclease VapC20
- Ribonuclease VapC28
- Ribonuclease VapC25
Sequence:
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAAGIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR
Protein: Wide host range VirA protein (WHR VirA) (EC 2.7.13.3) (P10799)
Organism: Agrobacterium tumefaciens (strain 15955)
Function: Activates VirG, by phosphorylating it, in the presence of acetosyringone or hydroxysyringone.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MNGRYSPTRQDFKTGAKPWSILALIVAAMIFAFMAVASWQDNATTQAILSQLRSINADSASLQRDVLRAHTGTVANYRPIISRLGALRKNLEDLKQLFRQSHIVSESNAAQLLRQLEVSLNSADAAVAAFGAQNVRLQDSLASFTRALSSLPGKASTDQTLEKPTELASMMLQFLRQPSPAISFEISLELERLQKQRGLDEAPVRILAREGPIILSLLPQVKDLVNMIQTSDTAEIAEMLQRECLEVYSLKNVEERSARIFLGSASVGLCLYIITLVYRLRKKTDWLARRLDYEELIKEIGVCFEGEAATTSSAQAALRIIQRFFDADTCALALVDHDRRWAVETFGAKHPKPVWDDSVLREIVSRTKADERATVFRIISSKKIVHLPLEIPGLSILLAHKSTDKLIAVCSLGYQSYRPRPCQGEIQLLELATACLCHYIDVRRKQTQCDVLARRLEHAQRLEAVGTLAGGIAHEFNNILGSILGHAELAQNSVSRTSVTRRYIDYIISSGDRAMLIIDQILTLSRKQERMIKPFSVSELVTEIAPLLRMALPPNIELSFRFDQMQSVIEGSPLELQQVLINICKNASQAMTANGQIDIIISQAFLPVKKILAHGVMPPGDYVLLSISDNGGGIPEAVLPHIFEPFFTTRARNGGTGLGLASVHGHISAFAGYIDVSSTVGHGTRFDIYLPPSSKEPVNPDSFFGRNKAPRGNGEIVALVEPDDLLREAYEDKIAALGYEPVGFRTFNEIRDWISKGNEADLVMVDQASLPEDQSPNSVDLVLKTASIIIGGNDLKMTLSREDVTRDLYLPKPISSRTMAHAILTKIKT
Protein: Homeobox protein CDX-4 (Caudal-type homeobox protein 4) (Q07424)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MYGSCLLEKEAGMYPGTLRSPGGSSTAGVGTSGGSGSPLPASNFTAAPVYPHYVGYPHMSNMDPHGPSLGAWSSPYSPPREDWSTYPGPPSTMGTVPMNDMTSPVFGSPDYSTLGPTSGASNGGSLPDAASESLVSLDSGTSGATSPSRSRHSPYAWMRKTVQVTGKTRTKEKYRVVYTDHQRLELEKEFHCNRYITIRRKSELAVNLGLSERQVKIWFQNRRAKERKMIKKKISQFENTGGSVQSDSGSISPGELPNAFFTTPSAVRGFQPIEIQQVIVSE
Protein: Restriction endonuclease (O53336)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- PPE family protein PPE8
- PE-PGRS family protein PE_PGRS28
- PPE family protein PPE55
- PPE family protein PPE56
- Uncharacterized protein Rv2209
- PE-PGRS family protein PE_PGRS43
- Probable membrane protein
- PE-PGRS family protein PE_PGRS30
- PPE family protein PPE5
Sequence:
MEYVQLFSKGRLNDLAGSLAGFLGKASQATAQRLQSWDADDLLNTPVDDVVEQLVELGSVECPDLRVDDAFMLPATEVDQQYRDWGEQRTRRVTRLVLVVPFEGHKDIFNLRPDQFTTMPPQVLRLQGHEIHLAIDNLSNDAAAINAAFHKQIANIEKYLGWSRRQIDLHNQGLRNELPGMVARRREQLLATRNLQAEIGFPVRRRKDADTYAAPISRKSVRPRPHRPAGARAAFKPEPAMQDEDYQSALRVLRNQRNALERTPSVAAKLDGEEIRDMLLVGLNAQFEGDAGGELFNGAGKTDILIRVDDRNIFIGECKVWSGPRTMDDVLKQLFGYLVWRDTKAAILLFIRNKDVTAVIDNAIAKIKEHPNHKRCPAHRAGADQYEFTMHADGDPEREIHLTLIPFALRPTAEVPTTTIP
Protein: Mitochondrial dicarboxylate/tricarboxylate transporter DTC (Dicarboxylate/tricarboxylate carrier) (Q9C5M0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the transport of dicarboxylates, such as oxoglutarate, oxaloacetate, malate, and succinate, and of tricarboxylates, such as citrate, isocitrate, cis-aconitate, and trans-aconitate by a counter-exchange mechanism across the inner mitochondrial membrane. Substrate preference in reconstituted proteoliposomes is oxaloacetate > malonate > malate > maleate > succinate > oxoglutarate > citrate > trans-aconitate > cis-aconitate > sulfate > isocitrate. May be important for plant metabolic functions requiring organic acid flux to or from the mitochondria, such as nitrogen assimilation, export of reducing equivalents from the mitochondria, and fatty acid elongation.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:12586869}; Multi-pass membrane protein {ECO:0000305|PubMed:12586869}.
Interaction partners:
- Mitochondrial phosphate carrier protein 3, mitochondrial
- ADP,ATP carrier protein 1, mitochondrial
- ADP,ATP carrier protein ER-ANT1
- FMN-linked oxidoreductases superfamily protein
- Mitochondrial pyruvate carrier 1
- Mitochondrial phosphate carrier protein 2, mitochondrial
- MD-2-related lipid recognition domain-containing protein / ML domain-containing protein
Sequence:
MAEEKKAPISVWTTVKPFVNGGASGMLATCVIQPIDMIKVRIQLGQGSAASITTNMLKNEGVGAFYKGLSAGLLRQATYTTARLGSFKLLTAKAIESNDGKPLPLYQKALCGLTAGAIGACVGSPADLALIRMQADNTLPLAQRRNYTNAFHALTRISADEGVLALWKGCGPTVVRAMALNMGMLASYDQSAEYMRDNLGFGEMSTVVGASAVSGFCAAACSLPFDFVKTQIQKMQPDAQGKYPYTGSLDCAMKTLKEGGPLKFYSGFPVYCVRIAPHVMMTWIFLNQITKFQKKIGM
Protein: LHFPL tetraspan subfamily member 2 protein (Lipoma HMGIC fusion partner-like 2 protein) (Q8BGA2)
Organism: Mus musculus (Mouse)
Function: Plays a role in female and male fertility. Involved in distal reproductive tract development.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MCHVIVTCRSMLWTLLSIVVAFAELVAFMSADWLIGKAKTRSGSGDEQAGMNSEPHYLGILCIRTPAMQQVSRDTLCGTYAKSFGEIASGFWQATAIFLAVGIFILCVVALVSVFTMCVQSIMRKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDCGRYASPYKPGDCSLGWAFYTATGGTVLTFICAVFSAQAEIATSSDKVQEEIEEGKNLVCLL
Protein: Guanylate kinase-associated protein mars (Q7K3L1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cell cycle regulator.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15922738}; Peripheral membrane protein {ECO:0000269|PubMed:15922738}. Nucleus, nucleoplasm {ECO:0000269|PubMed:15922738}. Cytoplasm {ECO:0000269|PubMed:15922738}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15922738}. Note=Localizes to the cell membrane of epithelial cells. Its subcellular localization dynamically changes during cell-cycle progression. At the prophase, it concentrates at the nucleoplasm. In the metaphase cells, it becomes diffusive in the cytoplasm and some is concentrated at the mitotic spindles and spindle poles.
Interaction partners:
- Protein abnormal spindle
- Kinesin-like protein Klp61F
- RE25723p
- Kinesin-like protein
- Ubiquitin-conjugating enzyme E2 C
- G2/mitotic-specific cyclin-A
- Monopolar spindle 1, isoform B
- RT07324p
- Chromosome associated protein G, isoform F
- Deterin
Sequence:
MQRHKELYKEQSLVLSPRNHCQENRDRLQAARAKKREDCFYQNRIISVSPTPVKIKQLAAAQAALTQENVAPKLESPERLDTKPAELLKESNPKVSRQKLYLQRYMEWKIAKTKEHKQQDQKRRGAAINVPTVKQSKALPKSQTFRVPDNLASAKQKEAAPMFQPPKRCSLYMIANPTGKGKAAEPIKPSIPKPTSAAAPPSSNTVAASSALARHKSAASATKIVPAIRQNNNPVALARQKAAARPIPNTTKQTTSVRQPGIEAKKITTTIPRPTPATVTKAKTPGIRQQPPVVSTKPRLPEPPAPRTARLPNVLSKPFEKPLGNKAPVTRRANVVKPQPIRGGGGAAAKFKDTAGATSKAASHSIRMKATKIKSQYTRLQDNVRKLPQLKAELLHAATLDIPPLTPLDDIHNPFIDQATSTQCKSNNSSGHLLEAFGDTILLSPVAPVKAEGESSVKRQLLPEGKKEASGPVAKKKFDFTRYSVANSPAEDSLILDPQQTTVKEDTGDSTLVPEGTKTPPRRESNGMPNYLSPFVSVSRGKVNSRCEKEKRNSFYLSNEESPLEVRRAIESVLYFRLQLENEITRLQALCAEWEAYSKENEARLQETGGIDMINVTIGQTRLLTTKKMMQFSGLIDRCEAGATGKNSQPNDGSEDSKPVQAEDLEGWWDMLRLQSENVDKRFDNLKRWKANDWLDPDAVAEEPKQPKPKPKISRNMKIKSKAKPSSNLQQFLRKAHANMKKTKVEEPTLEDGLPATSSRHSSPRVIVVRNRRSFSPARTVLRMSTGEGRQSIAPNALLKSAILAAAEQNAAKTPPPKPRTSILKTPGTTKRQNRGVLFSAKKSVRRFQFTYEEGNISNDETVGADKLEDCEEDMSLEASTESGSLEQNPGRDSNQENEATPRTYTLRNRRVNLRPSSEFM
Protein: Ig gamma-1 chain C region, membrane-bound form (P01869)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMNTNGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGLQLDETCAEAQDGELDGLWTTITIFISLFLLSVCYSAAVTLFKVKWIFSSVVELKQTLVPEYKNMIGQAP