wanglab/gogpt-training-data huggingface dataset:
Protein: Cyclin (Q9NG22)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MTIMMDGPKSSTRATETINQSDGQHRQQWCDRQQTGRNCNSAGSDSQSADPQQSGLHELGQLTAVAVERRCVEQRHLEHLYQSAFHSSHVPAISVWNYMRRIGKYSRCSPECFIICIIFIDRYVAATNCPITFRNIHRLLITSMLVSVKLRDDSFYSNSYFAGIGGVSNEELNRLEIEFLMTIDWRTWVEPSDFNMYCEQLRSRCSANQEQ
Protein: Endoplasmic reticulum vesicle protein 25 (P54837)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Possesses a C-terminal dilysine motif that interacts with COPI coat subunits. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Recycles between endoplasmic reticulum and Golgi.
Interaction partners:
- Protein ERP2
- Endosomal protein P24B
- Protein ERP1
- Protein ERP6
- GPI ethanolamine phosphate transferase 2
- GPI inositol-deacylase
- Protein ERP3
- Protein ERP5
- Protein ERP4
- ER-derived vesicles protein ERV14
Sequence:
MQVLQLWLTTLISLVVAVQGLHFDIAASTDPEQVCIRDFVTEGQLVVADIHSDGSVGDGQKLNLFVRDSVGNEYRRKRDFAGDVRVAFTAPSSTAFDVCFENQAQYRGRSLSRAIELDIESGAEARDWNKISANEKLKPIEVELRRVEEITDEIVDELTYLKNREERLRDTNESTNRRVRNFSILVIIVLSSLGVWQVNYLKNYFKTKHII
Protein: TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich motif associated to RING and Traf domains protein 1) (Q61382)
Organism: Mus musculus (Mouse)
Function: Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (By similarity). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BUZ4}. Nucleus {ECO:0000250|UniProtKB:Q9BUZ4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9BUZ4}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9BUZ4}. Cell membrane {ECO:0000250|UniProtKB:Q9BUZ4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BUZ4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9BUZ4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BUZ4}.
Interaction partners:
- Neutrophil cytosol factor 1
- Nucleotide-binding oligomerization domain-containing protein 2
- 5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial
- Interleukin-17 receptor A
- Transforming growth factor beta-1-induced transcript 1 protein
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Mitogen-activated protein kinase kinase kinase 3
Sequence:
MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVVPCPNRCPAKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPNQCGVGTVAREDLPTHLKDSCSTAFVLCPFKESGCKHRCPKLAMGRHVEESVKPHLAMMCALVSRQRQELQELRRELEELSIGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRASVELPRKILS
Protein: Uncharacterized protein C16H5.15 (Q9USY8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (Probable). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (By similarity). Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Gem-associated protein 7 homolog
- Uncharacterized protein new12
- SMN complex subunit smn1
- SMN complex subunit yip11/gem2
- Class E vacuolar protein-sorting machinery protein hse1
- DNA-binding protein rap1
- Polyubiquitin
- AN1-type zinc finger protein C1271.05c
Sequence:
MSSEITEGDLQKFHDEHFNAKAVNLWNVAFAQNDRGGNSESANVEYTQSVERYPDGTIRTLTDEQILWFRESEKRELMWKKEKEQLLKEKELRQKALDKERMVSSKPETNPKTPISLKELKDIEIYQNQFHYSAYEILEEEKILDNIFRKFTALPIKYWPATPIRG
Protein: Keratin-associated protein 15-1 (Q3LI76)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 8-1
- Keratin-associated protein 20-1
- Keratin-associated protein 24-1
- Keratin-associated protein 22-1
- Keratin-associated protein 20-2
- Keratin-associated protein 7-1
- Keratin-associated protein 11-1
- Keratin-associated protein 26-1
- Small cysteine and glycine repeat-containing protein 1
- Keratin-associated protein 27-1
Sequence:
MSYNCSSGNFSSCCFGSYLRYPVSTYNLFYPSNAIYSPNTCQLGSSLYNGCQETYCEPTSCQTSCTLARSYQTSCYCPKNSIFCSPRQTNYIRSLGCGNTGLGSLGCGSTGFQSLDCGSSFYHPTTFSSRNFQATCY
Protein: Transcriptional regulator LsrR (P76141)
Organism: Escherichia coli (strain K12)
Function: Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Autoinducer-2 kinase
- Autoinducer 2-binding protein LsrB
- 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
- (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase (Autoinducer 2-degrading protein LsrG) (AI-2-degrading protein LsrG) (Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase) (Phospho-AI-2 isomerase)
- Autoinducer 2 import system permease protein LsrD
- Autoinducer 2 import system permease protein LsrC
- Autoinducer 2 import ATP-binding protein LsrA
- PEP-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK
- S-ribosylhomocysteine lyase
- AI-2 transport protein TqsA
Sequence:
MTINDSAISEQGMCEEEQVARIAWFYYHDGLTQSEISDRLGLTRLKVSRLLEKGHQSGIIRVQINSRFEGCLEYETQLRRQFSLQHVRVIPGLADADVGGRLGIGAAHMLMSLLQPQQMLAIGFGEATMNTLQRLSGFISSQQIRLVTLSGGVGSYMTGIGQLNAACSVNIIPAPLRASSADIARTLKNENCVKDVLLAAQAADVAIVGIGAVSQQDDATIIRSGYISQGEQLMIGRKGAVGDILGYFFDAKGDVVTNIKIHNELIGLPLSALKTIPVRVGVAGGENKAEAIAAAMKGGYINALVTDQDTAAAILRS
Protein: Chromosome 10 open reading frame 90 (S4R3N7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
MQHSGIPTKTHPQGYAARYTETAVHRTFQIKTFSTELKNHVMVMDFVKSNWFPSQRRAKVCIIHMCQGLKTAEQTASRYEIHSRLFSSPKDHSAWERNESLSNAGLRDSYHSRRDQIALKNLQSDVTEAKSDFTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPKEERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTGLCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADGVDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCHASDHANQLSIHIPGWSYRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLPIGDSSPSDDCLSRDLSEPTERRHQSFLKPRILFPGFLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEALEVRKPQFISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKKKEEQRKRVILQSNRLRAEVFKKQLLDQLLQRNAV
Protein: Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (SMAD family member 1) (SMAD 1) (Smad1) (Q9I8V2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q15797}. Nucleus {ECO:0000250|UniProtKB:Q15797}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with Smad4. {ECO:0000250|UniProtKB:Q15797}.
Interaction partners:
- Mothers against decapentaplegic homolog.
- Serine/threonine-protein kinase receptor
- receptor protein serine/threonine kinase
- receptor protein serine/threonine kinase
- Receptor protein serine/threonine kinase
- Serine/threonine-protein kinase receptor
- SMAD family member 4.
- Mothers against decapentaplegic homolog
- Mothers against decapentaplegic homolog.
- Bone morphogenetic protein 2
Sequence:
MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELERALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKALECCEFPFGSKQKDVCINPYHYKRVDSPVLPPVLVPRNSEFNAKLSMLPRFRNPLHQTEPPMPQNATFPDSFPQQPANALPFTPNSPTNSYPSSPNSGTGSTATFPHSPSSSDPGSPFQMPETPPPAYMPPEEPMTQDCPQPMDTNLLAPNLPLEISNRTDVHPVAYQEPKHWCSIVYYELNNRVGEAFLASSTSVLVDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSRCSLKIFNNQEFAELLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAKYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Protein: peptidylprolyl isomerase (EC 5.2.1.8) (C1BFZ3)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein RACK1
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
Sequence:
MGVEIETITPGDGQTFPKKGQTCVVHYVGSLTDGTKFDSSRDRGKPFKFKIGKQEVIRGWEEGVGQMSVGQRATLTCTPDFAYGSKGHPGIIPPNSTLIFDVELMGLE
Protein: Erythropoietin receptor (EPO-R) (P19235)
Organism: Homo sapiens (Human)
Function: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P14753}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform EPOR-S]: Secreted {ECO:0000269|PubMed:11722595}. Note=Secreted and located to the cell surface. {ECO:0000269|PubMed:11722595}.
Interaction partners:
- Erythropoietin
- Tyrosine-protein kinase JAK2
- Neuroplastin
- Signal transducer and activator of transcription 5A
- Cytokine receptor common subunit beta
- Growth factor receptor-bound protein 2
- Signal transducer and activator of transcription 5B
- Thrombopoietin
- Tyrosine-protein kinase JAK1
- Transferrin receptor protein 2
Sequence:
MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS
Protein: F-box/LRR-repeat protein At3g48880 (Q9M2Z5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEEEYESRRLRRWEELDTDILVRIFQKFSVFELTSGLAHVCRGWRAACCDPILWKTVDLSNMRSSFIKIPLEPYVYVERRSDEALTRILKLSMNLSGGSTRTLIFHFNLFLSDDQLTYTAERCPGLRRVVLPAWNRIKKTGICKAIRIWKDLESLTMPSIANPPYLLTEIAKNCKNFKELKIMGPFEVFFANTLITCLPNIKTLSIRCSAIKREALMKILDGLPSLEVLNISHSHLVEYSGWQPQQKVIVRELDKTIMEKTARLKKFLTCMDHKTCVMCQRTENDEGIVRWYKYEEGDWKVDEVSSLHL
Protein: Protein AF1q (Q6FGF7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTATYKVKDSSVGKMIGQATAADQEKNPEGDGLLEYSTFNFWRAPIASIHSFELDLL
Protein: Na(+)/H(+) antiporter NhaB (Sodium/proton antiporter NhaB) (P0AFA7)
Organism: Escherichia coli (strain K12)
Function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 3 H(+) per 2 Na(+). Can also transport lithium. Essential for regulation of intracellular pH under alkaline conditions. Is necessary for growth on Na(+)/symport substrates such as glutamate and proline under conditions in which nhaA is not expressed, such as acidic pH and low Na(+) concentration.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01599, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01599}.
Interaction partners:
- Na
- Sodium-potassium/proton antiporter ChaA
Sequence:
MEISWGRALWRNFLGQSPDWYKLALIIFLIVNPLIFLISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMTSAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLICGLLTCLLVEKLRWFGYGETLPEKVREVLQQFDDQSRHQRTRQDKIRLIVQAIIGVWLVTALALHLAEVGLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIQFVLQASEHAQLSLFYIFNGLLSSISDNVFVGTIYINEAKAAMESGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTLVLTLVGLLCVEFTLAPVTEWFMQMGWIATL
Protein: Transcriptional activator Myb (Proto-oncogene c-Myb) (P06876)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:16162816}.
Interaction partners:
- Histone lysine acetyltransferase CREBBP
- Endothelial transcription factor GATA-2
- Runt-related transcription factor 1
- Transcription factor PU.1
- T-cell acute lymphocytic leukemia protein 1 homolog
- Histone acetyltransferase p300
- CCAAT/enhancer-binding protein beta
- Friend leukemia integration 1 transcription factor
- Myb-binding protein 1A
- Histone H3.2
Sequence:
MARRPRHSIYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNNHLMGFGHASPPSQLSPSGQSSVNSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQALPTQNHTCSYPGWHSTSIVDQTRPHGDSAPVSCLGEHHATPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHESSGLDAPTLPSTPLIGHKLTPCRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHAVEDLQDVIKQESDESGIVAEFQESGPPLLKKIKQEVESPTEKSGNFFCSNHWAENSLSTQLFSQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPCSGAWEPASCGKTEDQMTASGPARKYVNAFSARTLVM
Protein: Protein dead ringer (Protein retained) (Q24573)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription factor which is a downstream target of gcm and repo. Directly or indirectly activates the transcription of locos and pros, which are essential for the development of some glial cells. Plays an essential role in defining the cell shape and migration characteristics of longitudinal glia that enable them to establish a normal axon scaffold.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:8622680}.
Interaction partners:
- Polybromo
- Brahma associated protein 55kD
- Brahma associated protein 155 kDa
- Brahma-associated protein of 60 kDa
Sequence:
MQLRVHPTMDCSGRSTSNIERDSDLGDDLSHGDRTDDEMRDCDSVDGEHHQLSAKAAIAARLSHTVSGGGGSFASPEPQTELPLSHHHQLPPNHPLNALGSFMGIGGLHSIPNLQHSDVLEKLKMQVRDMKVGLMEQDYAAAAHAAAFGANMLPTTISSGFPLPHNSVAFGHVTSSPSGGNGSSYNGGTTPTNSSNSNATTNGGGTAGPGGTGGSGGGGGGGGGGGGGVGGHQFSFASPTAAPSGKEARHFAANSASNSSTSSEASNSSQQNNGWSFEEQFKQVRQLYEINDDPKRKEFLDDLFSFMQKRGTPINRLPIMAKSVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLHLPSSITSAAFTLRTQYMKYLYPYECEKKNLSTPAELQAAIDGNRREGRRSSYGQYEAMHNQMPMTPISRPSLPGGMQQMSPLALVTHAAVANNQQAQAAAAAAAAHHRLMGAPAFGQMPNLVKQEIESRMMEYLQLIQAKKEQGMPPVLGGNHPHQQQHSQQQQQQQHHHQQQQQQQSQQQHHLQQQRQRSQSPDLSKHEALSAQVALWHMYHNNNSPPGSAHTSPQQREALNLSDSPPNLTNIKREREREPTPEPVDQDDKFVDQPPPAKRVGSGLLPPGFPANFYLNPHNMAAVAAAAGFHHPSMGHQQDAASEGEPEDDYAHGEHNTTGNSSSMHDDSEPQQMNGHHHHQTHHLDKSDDSAIENSPTTSTTTGGSVGHRHSSPVSTKKKGGAKPQSGGKDVPTEDKDASSSGKLNPLETLSLLSGMQFQVARNGTGDNGEPQLIVNLELNGVKYSGVLVANVPLSQSETRTSSPCHAEAPTVEEEKDEEEEEEPKAAEEESHRSPVKQENEDVDQDMEGSEVLLNGGASAVGGAGAGVGVGVPLLKDAVVS
Protein: Sideroflexin-2 (Q925N2)
Organism: Mus musculus (Mouse)
Function: Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria (By similarity). Involved in mitochondrial iron homeostasis by regulating heme biosynthesis (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q96NB2}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96NB2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEGDLSGFNIDAPRWDQCTFLGRVKHFFNITDPRTVFASEQELDWAKAVVEKSRMGLVPPGTQMEQLLYAKKLYDSAFHPDTGEKMNVIGRMSFQVPGGMLITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMALSYFTATTTAVATAVGMNMWTKRAPPLVGRWVPFAAVAAANCVNIPMMRQQELIQGICVKDRNQNELGHSQRAAAVGIAQVVISRITMAAPGMILLPVIMERLERLHLMKKVKVMHAPLQVLLCGCFLLFMVPVACGLFPQECELSVSYLEPELRDTIKAKYGEQVLFVYFNKGL
Protein: Tail tip protein L (P03738)
Organism: Escherichia phage lambda (Bacteriophage lambda)
Function: Part of the distal tail tip complex which plays a role in DNA ejection during entry, and in tail assembly initiation during exit. The tail tip complex is assembled successively with three tail tip proteins J, one tail tip protein I, one tail tip protein L and one tail tip protein K. The tail tip complex interacts with tail measure protein to initiate tail tube assembly. The formation of the tail tip complex is completed by the addition of tail tip protein M, which is followed by tail tube polymerization.
Subcellular location: Virion. Host cytoplasm.
Interaction partners:
Sequence:
MQDIRQETLNECTRAEQSASVVLWEIDLTEVGGERYFFCNEQNEKGEPVTWQGRQYQPYPIQGSGFELNGKGTSTRPTLTVSNLYGMVTGMAEDMQSLVGGTVVRRKVYARFLDAVNFVNGNSYADPEQEVISRWRIEQCSELSAVSASFVLSTPTETDGAVFPGRIMLANTCTWTYRGDECGYSGPAVADEYDQPTSDITKDKCSKCLSGCKFRNNVGNFGGFLSINKLSQ
Protein: Sucrose:sucrose 1-fructosyltransferase (EC 2.4.1.99) (Sucrose 1(F)-fructosyltransferase) (Sucrose:sucrose 1(F)-beta-D-fructosyltransferase) (Q9FSV7)
Organism: Festuca arundinacea (Tall fescue) (Schedonorus arundinaceus)
Function: Transferase involved in fructan biosynthesis that catalyzes the production of 1-kestose (fructose and nystose to a lower extent) from sucrose. Exhibits also some hydrolase activity toward 1-kestose, thus producing fructose and sucrose. A weak fructosyltransferase activity leads to the formation of nystose from 1-kestose.
Subcellular location: Vacuole {ECO:0000250}.
Interaction partners:
Sequence:
MESSAVVPGTTAPLLPYAYAPLPSSADDARENQSSGGVRWRVCAAVLAASALAVLIVVGLLAGGRVDRGPAGGDVASAAVPAVPMEIPRSRGKDFGVSEKASGAYSADGGFPWSNAMLQWQRTGFHFQPEKHYMNDPNGPVYYGGWYHLFYQYNPKGDSWGNIAWAHAVSKDMVNWRHLPLAMVPDQWYDSNGVLTGSITVLPDGQVILLYTGNTDTLAQVQCLATPADPSDPLLREWIKHPANPILYPPPGIGLKDFRDPLTAWFDHSDNTWRTVIGSKDDDGHAGIILSYKTKDFVNYELMPGNMHRGPDGTGMYECIDLYPVGGNSSEMLGGDDSPDVLFVLKESSDDERHDYYALGRFDAAANIWTPIDQELDLGIGLRYDWGKYYASKSFYDQKKNRRIVWAYIGETDSEQADITKGWANLMTIPRTVELDKKTRTNLIQWPVEELDTLRRNSTDLSGITVDAGSVIRLPLHQGAQIDIEASFQLNSSDVDALTEADVSYNCSTSGAAVRGALGPFGLLVLANGRTEQTAVYFYVSKGVDGALQTHFCHDESRSTQAKDVVNRMIGSIVPVLDGETFSVRVLVDHSIVQSFAMGGRITATSRAYPTEAIYAAAGVYLFNNATGATVTAERLVVYEMASADNHIFTNDDL
Protein: Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Protein SUPPRESSOR 2 OF DA1) (Ubiquitin thioesterase 15) (Ubiquitin-specific protease 15) (AtUBP15) (Q9FPS9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (Probable). Involved in the regulation of organ size. Acts as positive regulator of cell proliferation. Possesses deubiquitinating enzyme activity in vitro. The enzyme activity of UBP15 is required for its function in regulation of cell proliferation. Functions antagonistically in a common pathway with DA1 to regulate seed size. Acts maternally to regulate seed size by promoting cell proliferation in the integuments of ovules and developing seeds. Functions independently of DA2 and BB.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18485060}. Nucleus {ECO:0000269|PubMed:18485060}.
Interaction partners:
- E3 ubiquitin-protein ligase DA2
- E3 ubiquitin-protein ligase BIG BROTHER
- Ubiquitin carboxyl-terminal hydrolase 14
- Protein DA1-related 1
- Protein SDA1
- Protein SDA1
- TRAF-like family protein
- Cytochrome P450 78A6
- Transcription factor TCP22
- Ubiquitin carboxyl-terminal hydrolase
Sequence:
MLEPRGADIPILFLVLVVLPVVAYILLGKWSNISEKRVRANLLAQMAAEEALRAETVVNADRGVRFESVATENRAQRTRTKTVSAGGGAVRAEFDAGARETVAEQRSDSVTATCGVTVVAPVNNNELHVCARCFGPAKTRCSRCKSVRYCSGKCQIIHWRVAHKDECVPVESCSSSSERVSFEKDSVLYDHGMDSTMYSNNTTQAAKGKTSKSSVDFASLGISQNDITPQINTQGRKSVGKQHSSKANRESCRRDSATVFDSSDEAASAGGDNKTSHIKHKSRGNSYAAETNPRRHSVDSSAVQMNGQSFVSGMQESHKHENNLGVRSSFGCPNTQYPSNGTRTATLPRTGINKSGEQSCTETSKKGQVAAVSKTVRSKDTGISEESNGISSTMGIMKMMGLRNSTKHDDRYKNLKMLFPYEEFLKFFQCEVFDLSPRGLVNCGNSCYANAVLQSLTCTKPLVAYLLRRSHSRSCSGKDWCLMCELEQHVMMLRESGGPLSASRILSHMRSINCQIGDGSQEDAHEFLRLLVASMQSICLERLGGETKVDPRLQETTLVQHMFGGRLRSKVKCLRCDHESERYENIMDLTLEIYGWVESLQDALTQFTRPEDLDGENMYRCSRCAGYVRARKELSIHEAPNILTIVLKRFQEGRYGKINKCISFPEMLDMIPFMTRTGDVPPLYMLYAVIVHLDTLNASFSGHYISYVKDLRGNWYRIDDSEIHPVPMTQVMSEGAYMLFYMRSYPRPQRGEHNGKAPVHHSQPRNEMKEQRKPVNRFKPRADHKNTESSSSEWSLFTSSDEASFTTESTRDSFSTIDYTDVCHVVDSSSPFAIFNNVYHNVEPSPHNTVACRMFSGTKPETRYFVEQETNHNNTVVLDATPSLYPIPAPYPPHDYYDQSMYVNYETNPEFNNGQDQDRTYSYW
Protein: Guanine nucleotide-binding protein subunit gamma (Q95ZG8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. This major G-protein of the squid photoreceptor is involved in visual transduction. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP.
Subcellular location: Cell membrane {ECO:0000305|PubMed:14517243, ECO:0000305|PubMed:16135826}; Lipid-anchor {ECO:0000305|PubMed:14517243, ECO:0000305|PubMed:16135826}; Cytoplasmic side {ECO:0000305|PubMed:14517243, ECO:0000305|PubMed:16135826}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta
- Guanine nucleotide-binding protein alpha-2 subunit
Sequence:
MSESQLKKVLKENETLKAQLEKSTTILKVSEACESLQDYCTKTSDPFIPGWSGENEWTKPLKGNGCSVL