wanglab/gogpt-training-data huggingface dataset:
Protein: Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Pentose-5-phosphate 3-epimerase) (PPE) (RPE) (O14105)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
Interaction partners:
- Probable transketolase
- Ribose-5-phosphate isomerase
- 6-phosphogluconate dehydrogenase, decarboxylating
- Xylulose kinase
- Transaldolase
- Eukaryotic translation initiation factor 3 subunit D
- Probable phosphoketolase
- Probable gluconokinase
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Fructose-bisphosphate aldolase
Sequence:
MVQAKIAPSLLAGDFANLEKEVGRMLKYGSDWLHVDVMDAQFVPNLTIGPIVVKAMRNHYTKEEAFFDCHLMVIEPERYIDQLADAGASLFCFHYEATEKHEEIISRAHEKGMLVGCALKPKTPVEVILPFVEKLDMVLVMTVEPGKGGQSFMPECLPKVEFLRKKYPTLNVEVDGGLSLKTVDAAADAGANVIVAGTAVFHAQSPEEVISGLRNSVMKAQETKPWFK
Protein: Protein E7 (Q6TY35)
Organism: Human papillomavirus 93
Subcellular location: Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04004}. Host nucleus {ECO:0000256|HAMAP-Rule:MF_04004}. Note=Predominantly found in the host nucleus. {ECO:0000256|HAMAP-Rule:MF_04004}.
Interaction partners:
Sequence:
MIGKEVTLQDIVLGLTPPEPVALNCEEELPTEQDTEEEPARTAFKIIVFCGGGCGSRLRIFVAATEFGVRCFQQLLVKELDLLCPNCRNSDLQHGGQ
Protein: Late embryogenesis abundant (LEA) protein (F4JQF1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMIMMLTTVVTLTWQKQCYGWGTETAEDMVRNEAEHAKNAAETAKKMASDAAHDTKDKTASWAGWVSDKISTGLGGKKAEAEEAAESAKNYAYDKAGSAYDNAGYAKDFASDKAGSAYDSAHNAKHYAYDKAGDAKDMAYDKTGQAKYMAYDKAGSAYEKAGQAKDMAYDKAGQAKDMAYDKVGSAYDKAGQAKDMAYDKAGSASEKAGQAKDFAYDKAAHAKDAAYNKAEDVIKMATDTSGEAKDSAYGTYERFKEGSKNAKDIASDKAHDVRETAGRAVDYAKDKANDAYESGSEAAGRFDEAMHKVGERYGAAKDSMSENTKEAYESAKEKASDAAGEYGSYMRDRSAEL
Protein: Uncharacterized protein Rv2082 (Q10690)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv2086
- PE-PGRS family protein PE_PGRS16
- ESX-4 secretion system protein eccD4
- Uncharacterized protein Rv2083
- Uncharacterized protein Rv2305
- Uncharacterized protein Rv2084
- Uncharacterized PPE family protein PPE3
- Uncharacterized protein Rv2085
- PE-PGRS family protein PE_PGRS2
- PE-PGRS family protein PE_PGRS43
Sequence:
MAGDLPPGRWSALLVGAWWPARPDAPMAGVTYWRKAAQLKRNEANDLRNERSLLAVNQGRTADDLLERYWRGEQRLATIAHQCEVKSDQSEQVADAVNYLRDRLTEIAQSGNQQINQILAGKGPIEAKVAAVNAVIEQSNAMADHVGATAMSNIIDATQRVFDETIGGDAHTWLRDHGVSLDTPARPRPVTAEDMTSMTANSPAGSPFGAAPSAPSHSTTTSGPPTAPTPTSPFGTAPMVLSSSSTSSGPPTAPTPTSPFGTAPMPPGPPPPGTVSPPLPPSAPAVGVGGPSVPAAGMPPAAAAATAPLSPQSLGQSFTTGMTTGTPAAAGAQALSAGALHAATEPLPPPAPPPTTPTVTTPTVATATTAGIPHIPDSAPTPSPAPIAPPTTDNASAMTPIAPMVANGPPASPAPPAAAPAGPLPAYGADLRPPVTTPPATPPTPTGPISGAAVTPSSPAAGGSLMSPVVNKSTAPATTQAQPSNPTPPLASATAAATTGAAAGDTSRRAAEQQRLRRILDTVARQEPGLSWAAGLRDNGQTTLLVTDLASGWIPPHIRLPAHITLLEPAPRRRHATVTDLLGTTTVAAAHHPHGYLSQPDPDTPALTGDRTARIAPTIDELGPTLVETVRRHDTLPPIAQAVVVAATRNYGVPDNETDLLHHKTTEIHQAVLTTYPNHDIATVVDWMLLAAINALIAGDQSGANYHLAWAIAAISTRRSR
Protein: Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Serine/threonine-protein kinase Unc51.2) (Unc-51-like kinase 2) (Q9QY01)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18443221}; Peripheral membrane protein {ECO:0000269|PubMed:18443221}. Note=Localizes to pre-autophagosomal membrane.
Interaction partners:
- Autophagy-related protein 13
- RB1-inducible coiled-coil protein 1
- Autophagy-related protein 101
- Beclin-1
- Beclin 1-associated autophagy-related key regulator
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Serine/threonine-protein kinase mTOR
- Autophagy-related protein 2 homolog B
- Phosphoinositide 3-kinase regulatory subunit 4
- Autophagy-related protein 2 homolog A
Sequence:
MEVVGDFEYCKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFARYLHSNTMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQVPVKKSCPVPVPVYSGPVPGSSCSSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASNSSKNSSCDTDDFVLVPHNISSDHSYDMPMGTTARRASNEFFMCGGQCQPTVSPHSETAPIPVPTQVRNYQRIEQNLISTASSGTNPHGSPRSAVVRRSNTSPMGFLRVGSCSPVPGDTVQTGGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHEARSRHSSGSPVPQTQAPQSLLLGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHAGAGYSYSPQPSRPGSLGTSPTKHTGSSPRNSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAESQSKDGNDPRECSHCLSVQGSERHRSEQQQSKAVFGRSVSTGKLSEQQVKAPLGGHQGSTDSLNTERPMDVAPAGACGVMLALPAGTAASARAVLFTVGSPPHSATAPTCTHMVLRTRTTSVGSSSSGGSLCSASGRVCVGSPPGPGLGSSPPGAEGAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNMMLMFTECVLDLTAVRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQVKSGKLSPSMAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSKILQDPTDVENVHKYKCSIERRLSALCCSTATV
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q9W149)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- BcDNA.GH11023
- Ribosome quality control complex subunit NEMF homolog
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
- Obelus
Sequence:
MQNGKPRSSARPSFHRRPKDGVANTTTDNAAVKPEALESYTGNDDNACVVCFKNVEIFSIGDCDHPVCYECSTRMRVLCQQNECPICRHVLSKVLFTLDKLPYRELEANNRSDLYSKKYRIGFCTAEIRQQFFKLLDHPCPKCDAPPYRTFEGLRNHVRSEHKLLYCDLCVETLNIFTFERRCYTQAELQLHNTKGDPDNRSHRGHPLCEYCNKRYVDRDELFRHLRREHYFCHFCDADGCNEFYNDYADLAEHFRAEHFLCEEGKCATEQFVGAFRNEIEYKAHVANVHGKSLNKQQAKQTRTLQVEITLGPRGRSGQTEQGITSVRTRNDEHNDYQNDLPSITQRHVSIDAGNEEQFPTLRGASTAPSVSLVRPPPPSMRNLSGTSGLARTKENFPALGGGNGGGVTGPTSSSIAARAAQSQHPVAAVFKKPTSAAGSGSRSGPPGNGMLLHVSNRSAAVPKKAATPQVDFPALPGKGNKKNLRNLEEDMLPSGSPVPMANISAKHRSLADDYVSVASPSTFQKLQMVQKEEDEAKARQEALKKSAPKLTAAEFPSLGPSASASSSRTTAPKPSSGSPSLNWSKPANEKKQRELENRKAKVAPAPVLPSPTSKPAPKASNNNVQEQQANKKDKKQKDKKSNQENQPKTAKPKERNNNNEQKTNGAPSTPIRAPPGLKPGGPLKPPPGFVSNVTVNSVAKLPNNLTFTNSLGESYDIVPSPYTYTDPPDTEVRNQKLVDEVMSLLKTPEALNEFRLLSSKFRDGSCSGQAYYEHCQCAMLSSFYNLFPELLAMLPDISKQQELYLVHKQHLNSLPPAERKSVPALEVCKVCKQILITADLKSHQQAHELTKNFPVLGSSASNTHRN
Protein: Fatty acid elongase 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELO1) (Elongation of fatty acids protein 1) (Very-long-chain 3-oxoacyl-CoA synthase 1) (P39540)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of a microsomal membrane bound medium-chain fatty acid elongation system, which extends medium-chain-length fatty acids to long-chain fatty acids. Component of elongase I, which extends 12-16-carbon fatty acyl-CoAs such as lauroyl-CoA to 14-18-carbon fatty acids by incorporation of malonyl-CoA.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Fatty acid elongase 2
- Acyl-CoA desaturase 1
- Very-long-chain 3-oxoacyl-CoA reductase
- Very-long-chain enoyl-CoA reductase
- Very-long-chain
- Fatty acid elongase 3
- 3-oxoacyl-[acyl-carrier-protein] synthase homolog
- Fatty acid synthase subunit alpha reductase
- Fatty acid synthase subunit beta dehydratase; Enoyl-[acyl-carrier-protein] reductase; [Acyl-carrier-protein] acetyltransferase; [Acyl-carrier-protein] malonyltransferase; S-acyl fatty acid synthase thioesterase]
- Acetyl-CoA carboxylase
Sequence:
MVSDWKNFCLEKASRFRPTIDRPFFNIYLWDYFNRAVGWATAGRFQPKDFEFTVGKQPLSEPRPVLLFIAMYYVVIFGGRSLVKSCKPLKLRFISQVHNLMLTSVSFLWLILMVEQMLPIVYRHGLYFAVCNVESWTQPMETLYYLNYMTKFVEFADTVLMVLKHRKLTFLHTYHHGATALLCYNQLVGYTAVTWVPVTLNLAVHVLMYWYYFLSASGIRVWWKAWVTRLQIVQFMLDLIVVYYVLYQKIVAAYFKNACTPQCEDCLGSMTAIAAGAAILTSYLFLFISFYIEVYKRGSASGKKKINKNN
Protein: Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2) (Q6ZPI3)
Organism: Mus musculus (Mouse)
Function: Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320}.
Interaction partners:
- Nuclear receptor-interacting protein 1
- Lysine-specific histone demethylase 1A
- Histone-lysine N-methyltransferase EZH1
Sequence:
MQRMIQQFAAEYTSKTSSTQDPSQPNSTKNQSLPKASPVTTSPTAATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCASSTSLSHSPGCSSTQGNGRPGRPSQYRPDGLRSGDGVPPRSLQDGTREGFGHSTSLKVPLARSLQISEELLSRNQLSTAASLGPSGLQNHGQHLILSREASWAKPHYEFSLSRMKFRGNGALSNISDLPFLAENSAFPKMAHQTKQDGKRDMSHSSPVDLKIPQVRGMDLSWESRTGDQYSYSSLVMGSQTESALSKKLRAILPKQNRKSMLDAGPDSWGSDAEQSTSGQPYPTSDQEGDPGSKQPRKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKERLGTLKNPPKKKMKLMRSEGPDVSVKIELDPQGEAAQSANESKTE
Protein: Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.-) (Q72A53)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase
- fructose-bisphosphate aldolase
- Enolase
- Glucose-6-phosphate isomerase
- Transketolase
- Pyruvate kinase
- 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
- Glyceraldehyde-3-phosphate dehydrogenase
- Transaldolase, putative
Sequence:
MSLNLGINGFGRIGRYLVRLLAEDNELSIAAINARADNASLAHLFKYDSCHGRFNGEVGHDADGLIVNGRHIAVTREKINEWRWGELGIDLAVETSGTVKDRAGLAQHIARGAKKCVISAPGKDADVTIVMGVNHGDYDPAKHDVISAASCTTNCLAPAAKVVHETFGIRHGIMTTVHSYTMSQRILDGSHKDLRRGRAAALSMIPTTTGAAKATALVYPALAGKLDGMAVRVPTPNVSLVDLTCELERETTVEEVNAALKAAAAGPMLGNMGFCEEPLVSIDFMGSTFGGVVDAQCTSVIDKTMLKLIIWYDNEAGFTNQLVRLLRMVGKSL
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q388V2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGGSSSANRNNRPPNRVSGSAPPPLHMPPHLAGQYPNQPLNAPPAAPAPPSVQMPNSPSGGASQYGVQEGQILKMLATVDPLSVRYDPATSTLNFSIISSTASLTYEVHTGVRMCVKNGDVYYMPNKPKMEPPRISLEGSQTTKDVSVVVDASNLDEIERVYNPQYPKQLPCVVVLRYRIKKSNVSGSGASAEPSSVFTEHTEHTTVDLAENVKQRVISQVVTSGGSAYVVENLYGACEENCVVGAQPEVVVGSSASGQGDDDDGLCVICLTLPKDTAVIPCRHMCLCKNCAEELVRHTPKCPVCRGPVSTLLHMPTVPLSSQV
Protein: Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta) (Q149T7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLNRVRSAVAHLVSSGGTSSQRSKSPDLPNATSAPPAAQETPKSSREKPGNQVGAPQKTAETTVSFSRPTFLQLSPGGLRRADDHAGRAVQSPPDTGRRLPWSTGYAEVINAGKSRHNEDQACCEVVYVESRRSRSVTGVSREPSHNQGFCFYYWGLFDGHAGGGAAEMASRLLHRHIREQLKDLVEILKDPLPPPLCLPSTPGTPGAPSPSQLVSPQSCWSPQKEVTHDSLIVGAIENAFHLMDEQMARERRGHQVEGGCCALVVLYLLGKMYVANAGDSRAIIVRNGEIIPMSREFTPETERQRLQLLGFLKPELLGSEFTHLEFPRRVQPKELGQRMLYRDQNMTGWAYKKIEVEDLRFPLVCGEGKKARVMATIGVTRGLGDHNLKVCSSTLSIKPFLSCFPEVRVYDLTQYEHCPDDVLVLGTDGLWDVTNDSEVAATVDRVLSSYEPNDPSRYTALAQALVLGARGIPRDRGWRLPNNKLGSGDDISVFVIPLGGPGSSYS
Protein: Glycine-rich RNA-binding protein RZ1C (AtRZ-1C) (Q8RWN5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds RNA and DNA sequences non-specifically. May be involved in tolerance to cold stress.
Subcellular location: Nucleus {ECO:0000269|PubMed:20850334}.
Interaction partners:
- Serine/arginine-rich splicing factor SC35
- Serine/arginine-rich splicing factor SR30
- Glycine-rich RNA-binding protein RZ1B
- Splicing factor U2af large subunit A
- DExH-box ATP-dependent RNA helicase DExH12
- Serine/arginine-rich splicing factor RS41
- Serine/arginine-rich splicing factor RS40
- Serine/arginine-rich SC35-like splicing factor SCL30
- ARM repeat superfamily protein
- Serine/arginine-rich splicing factor SR45
Sequence:
MAAKEGSRIFVGGLSPEVTDRDLERAFSRFGDILDCQIMLERDTGRSRGFGFITFADRRAMDESIREMHGRDFGDRVISVNRAEPKLGRDDGESHGSRGGRDSGYSIAGKGSFGGGGGGGGRVGEDECFKCGRVGHWARDCPSAGGGRGGPVGGFSSRASAYGGSDGRVDRYADRDRYVDRERYIDDRYDGAARYGARDRFDSREAYIPRDRYASDRYAAPADRFAGGDRYSRGSDRYPPGSYDKARSFERDIAPSAGSDRYGGGRAGGPIRGGGEEGRGFRSRAGAPYERPSRSGGGGAYPSSSTFDRY
Protein: Beta-galactosidase (EC 3.2.1.23) (A2BIK1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Si:dkey-165a24.9
- Si:dkey-26i13.8
- Musculoskeletal embryonic nuclear protein 1
- Phospholipid scramblase
- Solute carrier family 43 member 3 isoform X1
Sequence:
MSEREGLRADSTHFTLAGAPFRILGGSIHYFRVPRAHWRDRLLKLKACGLNTLTTYVPWNLHEPERGVYVFQDQLDLEAYIRLAAELDLWVILRPGPYICAEWDLGGLPSWLLQDKKMKLRTTYSGFTSAVNSFFDKLIPRITPLQYKKGGPIIAVQVENEYGSYAKDEQYLSVVKEALMSRGISELLMTSDNREGLKCGGVDGVLQTVNLQKLSYGDVQHLAELQPQKPLMVMEYWSGWFDVWGELHHVFSAQEMISIVRELLDRGVSINFYMFHGGSSFGFMSGAVDLGTYKPQTSSYDYDAPLTESGDYTTKYHLLRSLLSSYSKEPILEPPAVQSRRVYEPVVVTQHISLWESLQCVETSFRADDPVSMENLPANNNNGQSYGYTLYQTDIYSGGELNSRNHVRDRALVFIDRELIGVLDYRTQKVKIPQSKSERTLSLLVENCGRVNYGPALDSQQKGLVGDITLENVPLKKFTMHCLDMKPGFINRLQSRKWTSVSEKPTYPAFFRGSLVVDQPTDTFIKLPNWSKGVVFVNGQNLGRHWSVGPQKALYLPGPWLKTGENEIIVFEEFKATETIHFAENPEFGKTIDVSTQLFCTLM
Protein: Keratin, type I cytoskeletal 17 (Cytokeratin-17) (CK-17) (Keratin-17) (K17) (Q9QWL7)
Organism: Mus musculus (Mouse)
Function: Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16702408, ECO:0000269|PubMed:16710422}.
Interaction partners:
- 14-3-3 protein sigma
- Keratin, type II cytoskeletal 5
- Keratin, type I cytoskeletal 14
- Keratin, type I cytoskeletal 16
Sequence:
MTTTIRQFTSSSSIKGSSGLGGGSSRTSCRLSGSLGAGSCRLGSASGLGSALGSNSYSSCYSFGTGSGYGGNFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQKQAPGPARDYSAYYHTIEDLKNKILVATVDNASILLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGSLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKPKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR
Protein: Uncharacterized protein C30D11.11 (Q09910)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- GTP cyclohydrolase 1
Sequence:
MSTVKTFSSTETEGFKKRLLSRRHSSYQVRDEEDDVLEEFIVLKLDLFLTRLNHRMKRLEELGLPNRKDAAAATYQFLANLQASFLGTTILGKTQVSFILRRIEETYNDVLSACDTFPAKAQKALTFLEHHLRDLEDYAEKSKNNVETLMTDIKDVVEHAAKLGAQRLITLEELPVQWHNNPYIIRGYRFYTSKRKCFRSILSWHNETFNIWTHLSAFIVFFAVLAYFYPSSSSWVSSNVSNRIVRIFFLLSAMKCLGCSVIWHTFSSLSNYKHMRCAACMDYVGISALIAASIISVEYHAFVCQGPLRFIFIAFTGTLGLIGIYTPWKKWFNEYKYRSVKIFFFVGLACSGLIPMITMFYIKGTRRTVKYLDPVFKSIFSYIIGVLFYGLHIPERFLPGKFDIIGNSHQIWHIAIIVGVAFHYTGVKRFETDYEAFSCGVL
Protein: Relaxin-3 (Insulin-like peptide INSL7) (Insulin-like peptide 7) (Prorelaxin R3) [Cleaved into: Relaxin-3 B chain; Relaxin-3 A chain] (Q8BFS3)
Organism: Rattus norvegicus (Rat)
Function: May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Relaxin-3/INSL7 receptor 1 long form.
- Relaxin receptor 1
- Relaxin receptor 2
- Prorelaxin 1
- Insulin-like 3
- Insulin-like peptide INSL6
- Neuropeptide S
- G-protein coupled receptor 135
- RLF zinc finger
- Neuropeptide Y receptor type 5
Sequence:
MATRGLLLASWALLGALVLQAEARPAPYGVKLCGREFIRAVIFTCGGSRWRRADILAHDPLGEFFADGEANTDHLASELDEAVGSSEWLALTKSPQVFYGGRSSWQGSPGVVRGSRDVLAGLSSSCCEWGCSKSQISSLC
Protein: Patatin-like phospholipase domain-containing protein 4 (EC 3.1.1.3) (Calcium-independent phospholipase A2-eta) (iPLA2-eta) (EC 3.1.1.4) (Protein GS2) (P41247)
Organism: Homo sapiens (Human)
Function: Has abundant triacylglycerol lipase activity. Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides. Additionally possesses acylglycerol transacylase and phospholipase A2 activities.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:26741492}.
Interaction partners:
- Dehydrogenase/reductase SDR family member 4
- Retinol dehydrogenase 8
- All-trans-retinol 13,14-reductase
- Retinol dehydrogenase 12
- Retinol dehydrogenase 11
- Retinoid isomerohydrolase
- Cytochrome P450 26A1
- Alcohol dehydrogenase class-3
- Alcohol dehydrogenase 1C
- Epidermal retinol dehydrogenase 2
Sequence:
MKHINLSFAACGFLGIYHLGAASALCRHGKKLVKDVKAFAGASAGSLVASVLLTAPEKIEECNQFTYKFAEEIRRQSFGAVTPGYDFMARLRSGMESILPPSAHELAQNRLHVSITNAKTRENHLVSTFSSREDLIKVLLASSFVPIYAGLKLVEYKGQKWVDGGLTNALPILPVGRTVTISPFSGRLDISPQDKGQLDLYVNIAKQDIMLSLANLVRLNQALFPPSKRKMESLYQCGFDDTVKFLLKENWFE
Protein: Stromal cell-derived factor 1 (SDF-1) (12-O-tetradecanoylphorbol 13-acetate repressed protein 1) (TPAR1) (C-X-C motif chemokine 12) (Pre-B cell growth-stimulating factor) (PBSF) (Thymic lymphoma cell-stimulating factor) (TLSF) (P40224)
Organism: Mus musculus (Mouse)
Function: Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells.
Subcellular location: Secreted.
Interaction partners:
- C-X-C chemokine receptor type 4
- Atypical chemokine receptor 3
- C-C chemokine receptor type 7
- C-C chemokine receptor type 2
- C-X-C chemokine receptor type 5
- C-X-C motif chemokine 9
- C-X-C chemokine receptor type 3
- C-X-C chemokine receptor type 2
- Chemokine subfamily B Cys-X-Cys
- C-C chemokine receptor type 5
Sequence:
MDAKVVAVLALVLAALCISDGKPVSLSYRCPCRFFESHIARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRLKM
Protein: NAD(+) diphosphatase (EC 3.6.1.22) (Q5AU26)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Glutamine-dependent NAD
- 5'-nucleotidase
- nicotinate phosphoribosyltransferase
- Pyrimidine 5'-nucleotidase, putative
- Nicotinamide-nucleotide adenylyltransferase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- IMP-specific 5'-nucleotidase 1
- NAD+ kinase Utr1, putative
- NAD-dependent protein deacetylase hst2-1
- NAD+ kinase, putative
Sequence:
MSNNSQIPNPAHIQADSMLARRFGKETVNYFSSSPLNRLSFLRSDHPFLSAAFKHPSTRFVILKDLAPLTRSPTELYYAKYDEVRKLLPASIYDKSEEEIIKEHDSRKTEPHLIFLGVDETDKQQDGFSWKIYSGTPYFALDVSEKGSEEQQHNAKEVVNGFEAQGLSFLQARVAMTFSANEAAIYAQARALIDWNTRNSYCGTCGSRTISVNSGTKRACPPTDAARVAEGKPAEKPACSTRTTISNLSFPRTDPTIIVAVISSDAKRILLGRSKRFPPNWYSTLAGFIEPAESVEDAVRREVWEEAGVTLSRVIIHSTQPWPYPANLMIGAIAQVSDPAHEKINLEHDPELEDARWFEIEEVEEALRVGTSNLDQAAGPGYKEGSLRLPPPTAIANQLIQAAINIDFLADKSKM
Protein: Cyclin/Brf1-like TBP-binding protein (F4IW19)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Homeodomain-like superfamily protein
- Tetratricopeptide repeat
- DNA-directed RNA polymerase III subunit RPC6
- DNA-directed RNA polymerase III subunit 2
- DNA-directed RNA polymerase III subunit 1
- Plant-specific TFIIB-related protein 2
- Transcription initiation factor IIB-2
- Transcription initiation factor IIB-1
- Plant-specific TFIIB-related protein 1
- TATA-box-binding protein 2
Sequence:
MVWCKHCGKNVPGIRPYDAALSCDLCGRILENFNFSTEVTFVKNAAGQSQASGNILKSVQSGMSSSRERIIRKATDELMNLRDALGIGDDRDDVIVMASNFFRIALDHNFTKGRSKELVFSSCLYLTCRQFKLAVLLIDFSSYLRVSVYDLGSVYLQLCDMLYITENHNYEKLVDPSIFIPRFSNMLLKGAHNNKLVLTATHIIASMKRDWMQTGRKPSGICGAALYTAALSHGIKCSKTDIVNIVHICEATLTKRLIEFGDTEAASLTADELSKTEREKETAALRSKRKPNFYKEGVVLCMHQDCKPVDYGLCESCYDEFMTVSGGLEGGSDPPAFQRAEKERMEEKASSEENDKQVNLDGHSDESSTLSDVDDRELDCYFRTPEEVRLVKIFFDHENPGYDEKEAAKKAAGLNACNNASNIFEASKAAAAKSRKEKRQQRAEEEKNAPPPATGIEAVDSMVKRKKFRDINCDYLEELFDASVEKSPKRSKTETVMEKKKKEEHEIVENEQEEEDYAAPYEQDEEDYAAPYEMNTDKKFYESEVEEEEDGYDFGLY
Protein: Protein GOLVEN 5 (CLAVATA3/ESR (CLE)-related protein CLEL1) (CLE-Like protein 1) (Root meristem growth factor 2) (AtRGF2) [Cleaved into: GLV5p] (Q6DSU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Signaling peptide (root growth factor) that maintains the postembryonic root stem cell niche in a PIN2-traffic dependent manner. Root growth factor that regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells (By similarity). Influences the longitudinal growth rate in the primary root in response to phosphate ion (Pi)-deprivation.
Subcellular location: [GLV5p]: Secreted {ECO:0000250|UniProtKB:Q3E880}.
Interaction partners:
- LRR receptor-like serine/threonine-protein kinase RGI3
- Protein GOLVEN 11
- Protein GOLVEN 10
- Protein GOLVEN 6
- Protein GOLVEN 3
- Protein GOLVEN 9
- Protein GOLVEN 1
- Protein GOLVEN 2
- Protein FANTASTIC FOUR 4
- Root meristem growth factor 10
Sequence:
MTNITSSFLCLLILLLFCLSFGYSLHGDKDEVLSVDVGSNAKVMKHLDGDDAMKKAQVRGRSGQEFSKETTKMMMKKTTKKETNVEEEDDLVAYTADYWKPRHHPPKNN