wanglab/gogpt-training-data huggingface dataset:
Protein: cysteine-S-conjugate beta-lyase (EC 4.4.1.13) (Cysteine-S-conjugate beta-lyase) (Q5AXC9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Cysteine synthase 1
- 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
- Cystathionine beta-synthase
- cystathionine gamma-synthase
- Homocysteine S-methyltransferase
- Cysteine synthase 2
- Adenosylhomocysteinase
- Thiosulfate sulfurtransferase, putative
- Homocysteine synthase
- Homoserine dehydrogenase
Sequence:
MSASSTLKKAFPQVDAEGHNLPPSPAPSSPHGSRRYNIATELVYTESNDQYNASSVPIYQSATFKQSSHEGGGEYDYTRSGNPTRTHLERHLAKIMSAQRALVVSSGMAALDVITRLLRPGDEVVTGDDLYGGTNRLLKYLSTNGGIIVHHVDTTNPDKVKEVLTDKTAMVLLETPTNPLIKIVDIPTIAAASHEANPNCLVIVDNTMMSPLLLSPLELGADVVYESGTKYLSGHHDVMAGVIAVNDPALGERLYFPINASGCGLSPFDSWLLMRGVKTLKVRMDQQQANAQRIAEFLESHGFKVRYPGLRSHPQYDLHHSMARGAGAVLSFETGDVSVSERIVANAKLWAISVSFGCVNSLISLPCRMSHASIDAKTRKERAMPEDLIRLCVGIEDVDDLIDDLRRAVSVSTRNRVFWVMLIFSSWYKLALSTSLWTALKRTRRSLRSQVMKEYGYG
Protein: DNA 5'-3' helicase (EC 5.6.2.3) (Q7KVP9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- General transcription factor IIH subunit
- General transcription factor IIH subunit 3
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIH subunit 4
- General transcription factor IIH subunit 1
- Cyclin-dependent kinase 7
- Cyclin-H
- DNA repair protein complementing XP-A cells homolog
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIE subunit 1
Sequence:
MKLSVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPETVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAVDGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNHLTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRNADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISDLTEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVVITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNYGQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYVKACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIRENDFLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHLVDSFCNLSTEEAVQLARRWLRRMAQPFTREDQLGISLLTLAQLENMEQEKLERQAQGKQGVGGEVQEL
Protein: Non-classical arabinogalactan protein 30 (AtAGP30) (P93013)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Proteoglycan required for the timing of seed germination. May function in the abscisic acid (ABA) response.
Subcellular location: Secreted, cell wall {ECO:0000250|UniProtKB:Q9FZA2}.
Interaction partners:
- Classical arabinogalactan protein 4
- Leucine-rich repeat extensin-like protein 6
- Lysine-rich arabinogalactan protein 17
- CCT motif family protein
- Fasciclin-like arabinogalactan protein 4
- RING-type E3 ubiquitin transferase
- At5g45880
- AT1g27100/T7N9_16
- Allergen, putative
- Arabinogalactan protein 22
Sequence:
MGIIGKSVSLTLFALLCFTSSVFTLGVNQPGSSDPFHSLPQHLPLPPIKLPTLPPAKAPIKLPAYPPAKAPIKLPTLPPAKAPIKLPTLPPIKPPVLPPVYPPKYNKTLVAVRGVVYCKACKYAGVNNVQGAKPVKDAVVRLVCKNKKNSISETKTDKNGYFMLLAPKTVTNYDIKGCRAFLVKSPDTKCSKVSSLHDGGKGSVLKPVLKPGFSSTIMRWFKYSVYNVGPFAFEPTCPK
Protein: NADPH-dependent quinone reductase ArsH (EC 1.6.5.2) (Arsenical resistance operon protein ArsH) (P74312)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Has high NADPH-dependent quinone reductase activity with a preference for quinones with hydrophobic substituents. Reduces also CrO4(2-) and Fe(3+). Somewhat active with NADH. May be involved in response to oxidative stress caused by arsenic.
Interaction partners:
- Uncharacterized transporter slr0944
- Glutaredoxin arsenate reductase
- Slr0303 protein
- Magnesium transport protein CorA
Sequence:
MTDFNHPPRILFLYGSLRERSYSRLLAEEAGRIITTMGAETKFFDPRELPLRGQVLDSHPKVQELLELSQWSEGQVWSSPEMHGNITGILKNQIDWIPLEIGSIRPTQGRTLAVMQVSGGSQSFNAVNTMRILGRWMRMFTIPNQSSVAKAYQEFHEDGTMKDSPYRDRVVDVMEELYKFTLLLRDKVDYLTDRHSERKAKVNTDG
Protein: Kinesin-like protein klp-19 (O45935)
Organism: Caenorhabditis elegans
Function: Required for chromosome movement and orientation on spindle poles in mitosis and meiosis. May play a role in early anterior-posterior chromosome movement in mitotic embryos.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:15452142}. Nucleus {ECO:0000269|PubMed:15452142}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15452142}. Chromosome {ECO:0000269|PubMed:15452142}. Note=Localizes to nuclei of the distal mitotic zone (PubMed:15452142). During mitotic prophase in embryos, localizes to the nucleoplasm (PubMed:15452142). In prometaphase, localizes to the body of the spindle and the periphery of chromosomes (PubMed:15452142). In anaphase, localizes to the spindle interzone (PubMed:15452142). Localizes to early meiotic prophase nuclei and to the nucleoplasm in late prophase (PubMed:15452142). Localizes to prophase chromosomes before fertilization (PubMed:15452142). During metaphase of meiosis I and meiosis II, localizes to the body of the spindle, around the periphery of chromosomes, and between homologous chromosomes (PubMed:15452142). {ECO:0000269|PubMed:15452142}.
Interaction partners:
- Mitotic checkpoint serine/threonine-protein kinase bub-1
- Aurora/IPL1-related protein kinase 2
- Calponin-homology
- Chromosomal passenger complex protein bir-1
- Kinesin-like protein
- Kinetochore protein Nuf2 homolog
- Protein CLASP-2
- Protein regulator of cytokinesis 1
- Rac GTPase-activating protein 1
- Separin homolog sep-1
Sequence:
MSSDASLRVVVRARPMNGRETKEGASRCVQFYENTKQIVINESATFTFDAVFADTSDQESVYETTALPLLDRIFAGFNATVLAYGQTGSGKTYTMGTEDNVGTDEMRRGIIPRLVSALFQRIMNTEAPESFAVTVSMFEVYGDNVYDLLRPDKVKLNVHGDEKNCTVVNLTAVPVIDLKGALKQLAVGCHYRTKAETAMNAMSSRSHAVFTVFVEKTATAECDSAFSAKLQLVDLAGSERLKKTEAEGNRMKEGININGGLLILSQVIAALATKQKHIPYRNSVITRVLQDSLGGNSFTVFLACISPADSNSQETLNTLRYADRAKQIKNKPIVNKNPKAEEIAILQAQLKRLQKENADLKQGIAPAEVRFNDANNSAEILSLKEEVVRKTEQLKERAMKQSECIIRMSALTQKNSRLEEDKAKLQSMLTDVRNTVLNEEMLDAAEVVRSIQQVVGDTEESTTLADDDNDETALGGQDDTIYDTERLPELQAELDDLEKQIAMKDENRQKALDEQRAFIEAMQQRESEKTQLVVRISELETEMNKLRQEGKKVTTAAKLAEERRQKLKDLERQHAEDKKVLNDMKKLQETRRRMEETLKKTEDELKNLKTQRLRLLREQRAEASKFQAFKQKHEREMAQMKSKLQKRENDVAIQKRMTDQKLTVLQMRLTEANRANKTLRELNLKRANRKSSPTNASALQNMIEEELEHEMCAQRSHWLCEDLRRQRHDLMQNINTVESMKFEGGKRRRISASADPNVSVVIEGEEEFEVKRQKELTFLRASLETLNEEIKDSLRNETIAGNEERANSRWEKVPAEMRPAFEAVYAQAVAHIRKEIELEFKLARTKSEFTAKIASKASHEEKRKKEDEEMRAKYRELAQCLEDAKSGLHEKIAFLLCLIKENRVDENAIQQFESLKNQFCDVEQKVKKASRRKTTNFMGGLTPKPELQRNERARRAVKYYGNVVNSEDVTMDDSRHQKRKDHSLLAVEMNRTTDDNVKRRVAMSPIKCDDDTRLTEEDEDIENEAMNNATFVKDSFNSATIVLDDSQPSPSNSTFVIGAAPTSEADGVPPIKRKSRRTDLGPL
Protein: Regulator of G-protein signaling 22 (RGS22) (Q8NE09)
Organism: Homo sapiens (Human)
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18703424}. Nucleus {ECO:0000269|PubMed:18703424}. Note=Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.
Interaction partners:
- F-box only protein 43
Sequence:
MPEKRLTAEPPTITEEEFEDSLATDDFLVDYFNEFLSLPTFSEAIRFNADYGVFEVANDAPQFLEKQLKKILQNQQPRNPIYDVVRKGKNEVKPVQMNAPDEDETINVNYNIMCLSREEGIKWIKKERLPAFLESDCYFEYRLAKLVSQVRWSKSGMNFTVGSNFSPWIVKKPPSLPPPATEEDNLVIMKKFYVSLGEASYTQTKDWFALAKQSQQTVSTFSLPCCVPYNKLKSPAISSVSENFIFDDGVHPRTKKDPSKTNKLISEFEEEEGEEEEVSVSLQDTPSQALLRVYLEKKQDVDESLTMHFSTCEEFLSSYIYFILRGAIQQIVGKPVGETPDYINFNNITKVSFDDCFESIHGKNFLSELVQTTKERSEEIEQTSLSSKNESAGPESRADWCISHRTYDIGNRKEFERFKKFIKGTLGERYWWLWMDIERLKVLKDPGRHQRHLEKMKKCYLVSNGDYYLSAEILSKFKLLDGSQWNEEHLRNIQSEVLKPLLLYWAPRFCVTHSASTKYASAELKFWHLRQAKPRKDIDPFPQMATLLPLRPKSCIPQIPEIQKEEFSLSQPPKSPNKSPEVKTATQKPWKRELLYPGSSKDDVIEKGSKYMSESSKVIHLTSFTDISECLKPQLDRRYAYTEEPRVKTVSDVGALGGSDMENLLQSLYVENRAGFFFTKFCEHSGNKLWKNSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYMKIQPPFEDLFDTAEEYILLLLLEPWTKMVKSDQIAYKKVELVEETRQLDSTYFRKLQALHKETFSKKAEDTTCEIGTGILSLSNVSKRTEYWDNVPAEYKHFKFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKNKYLNKKYFFGPNSPASLYQQNQVMHLSGGWGKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQFAARQKIKVQMKDIAEELLLQKAEKKIGVWKPVESKWISSSCKIIAFRKALLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKIIEHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDENIMSVLERRQEYNKQKKKLAVLEDEKSGKDGIKQYANTSVPAIKTALLSDSFLGLQPYGRQPTWCYSKYIEALEQERILLKIQEELEKKLFAGLQPLTNFKASSSTMSLKKNMSAHSSQK
Protein: Eyes absent homolog (EC 3.1.3.48) (Q6P4T3)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEEEQDLPEQPVKKAKMQEPREQTLSQVNNPDASDEKPETSSLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFASSTNASLIPTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAETTTLAATTYQTEKPSAMVPAPATQRLPSDSSASPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCANVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
Protein: Hemolysin II regulatory protein (Q7X506)
Organism: Bacillus cereus
Interaction partners:
Sequence:
MGKSREQTMENILKAAKKKFGERGYEGTSIQEIAKEAKVNVAMASYYFNGKENLYYEVFKKYGLANELPNFLEKNQFNPINALREYLTVFTTHIKENPEIGTLAYEEIIKESARLEKIKPYFIGSFEQLKEILQEGEKQGVFHFFSINHTIHWITSIVLFPKFKKFIDSLGTNETNDTNHEWMPEDLVSRIISALTDKPNI
Protein: Protein NUD1 (P32336)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in astral microtubule organization by binding SCP72 to the outer plaque in a cell-cycle dependent manner. Required for the mitotic exit by facilitating the binding of TEMP1 to CDC15. Also involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:10330408}. Nucleus envelope {ECO:0000269|PubMed:10330408}. Note=Localizes to the meiotic outer plaque of the SPB, at the end of the meiotic spindles.
Interaction partners:
- Cell division control protein 15
- Protein TEM1
- Mitotic check point protein BUB2
- DBF2 kinase activator protein MOB1
- Gamma tubulin complex adapter SPC72
- Dynein heavy chain, cytoplasmic
- Cell cycle serine/threonine-protein kinase CDC5/MSD2
- Cell cycle protein kinase DBF2
- Tyrosine-protein phosphatase CDC14
- Chaotic nuclear migration protein 67
Sequence:
MDMDTQEAELSSQLENLTINSPRKLRSNAHSNSGKVFKEYESNHDFQDSNFTSQVVEPAISDSVKKPPTMTVLNNYSTVHQKVPSGFSGTTATSHQEAQWKQYFPGIGSGGGTNFGGAVGTANKVPESDLIVSDLVKDLSGVLETNTFKRHLDMKNKTTTMQTHENHDTISISHSKDFFNAEKVSSSFSDDSDSGPAAEAHDVFDGILQKQKSNYLVGSYPSNSNNKNNNNNNNNNNNNSININNKDNARTKEEDEEDTSNSFEFSSSSSMSSSQTQSGRKSKVLKKPPLNTISPGQLGYQFNHTHGAWDPPLNQGLDVSSSHSLDNTSSNQSQFATMVPTGDNHTNGKAPSILDKKAYELTSTKPGDVGYRQKKIQEEENLANSDDTPLDTPKFNDLFTKNGTRAKVKGQMRTSRSISNSNLLEAHKKLKTFPAERVEDITSISEVNTSFNETEKQLISILTSKLSGSPSYDSDWEKILKVDLSRGKLKNMFGMQRLLPNVLVLNLSDNEMNTLEGIPSNVVQLFCSNNKITSAHCSLAGFHDLECLDLSYNLLNTSLKFLSLCHHLQEVNLSYNSIQSLEGIGSSRMKKLNLSNNEINGIIDFEQLILTNNSVVGGWLTVEVLDLSNNNIIGVRNINCLPRLKVLNLNGNPLVSIVESSKMENGTLRALSIKNTGGALSKLQNYKLDDQFTFPYQNLKILKLDGFAQLSKWQKWPATLQILEINGGLASSLPRFSSLKSTNLYSLTIANVRDFTHLPVDLSKELPFLQELHLPGNNLQNAHKLTKTLPRQSVKFLDLRNNPITTPRHDRASTSLHYRQLLQLAGLCQQQCPALATLWLDDTPAPTATNL
Protein: Probable mannosyltransferase. Probable conserved transmembrane protein (O06152)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Polyprenol-phosphate-mannose-dependent alpha-
- Alpha-
- Terminal beta-
- Uncharacterized protein Rv2079
- Uncharacterized protein Rv0048c
- Polyprenol-phosphate-mannose-dependent alpha-
Sequence:
MHASRPGAPPHAGLPSRRTAGDQDHRADPKVTRIMSASTLEQPAAAHVDELVARMRGRLLDPLAIAVLAAVISGAWASRPSLWFDEGATISASASRTLPELWSLLGHIDAVHGLYYLLMHGWFAIFPPTELWSRLPSCLAIGAAAAGVVVFAKQFSGRTTAVCAGAVFAILPRVTWAGIEARSSALSVAAAVWLTVLLVAAVRCNTQRRWLLYALVLMLSILVSINLALLVPAYATMVPLLASGKSRKSPVIWWTVVTAAALGAMTPFILFAHGQVWQVGWIAGLNRNIILDVIHRQYFDHSVPFAILAGLIVAAGIAAHLAGARGPGGDTHRLVLVSAAWIVVPTAVVLIYSATVEPIYYPRYLILTAPAAAVILAVCVVTIARKPWLIAGVVFLLAAAAFPNYFFTQRGPYAKEGWDYSQVADVISAHAKPGDCLLVDNTAGWRPGPIRALLATRPAAFRSLIDVERGTYGPKVGTLWDGHVAVWLTTAKIDKCPTLWTIANRDKSLPDHQVGEMLSPGTGFGRTPVYRFPSYLGFRIVERWQFHYSQVVKSTR
Protein: Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) (Q63054)
Organism: Rattus norvegicus (Rat)
Function: May play a role in neurotransmitter secretion.
Subcellular location: Cytoplasm, cytosol. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules. {ECO:0000250}.
Interaction partners:
- PRKCA-binding protein
- Ras-related protein Rab-2A
Sequence:
MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQCRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEKKKSSRRENREAVAQEPRQLISLEEENQHKESSTCQKEEGKSVPSSVDKSSADDACSGPIDELLDVKPEEACLGPMAGTPEPESGDKDDLLLLNEIFSTSSLDEGEFSREWAAVFGDDRLKEPAPMGAQGEPDPKPQIGSAFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAIGKTDKEHELLNA
Protein: Transmembrane protein 74 (Q96NL1)
Organism: Homo sapiens (Human)
Function: Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:18294959}; Multi-pass membrane protein {ECO:0000269|PubMed:18294959}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:18294959}; Multi-pass membrane protein {ECO:0000269|PubMed:18294959}.
Interaction partners:
- Autophagy-related protein 16-1
- Autophagy-related protein 9A
Sequence:
MELHYLAKKSNQADLCDARDWSSRGLPGDQADTAATRAALCCQKQCASTPRATEMEGSKLSSSPASPSSSLQNSTLQPDAFPPGLLHSGNNQITAERKVCNCCSQELETSFTYVDKNINLEQRNRSSPSAKGHNHPGELGWENPNEWSQEAAISLISEEEDDTSSEATSSGKSIDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLEKESARLGAHLDRCVIAGLCLLTLGGVILSCLLMMSMWKGELYRRNRFASSKESAKLYGSFNFRMKTSTNENTLELSLVEEDALAVQS
Protein: Assembly chaperone of RPL4 (Q03771)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a chaperone for the L4 ribosomal subunit encoded by RPL4A and PRPL4B, required for hierarchical ribosome assembly. Shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:25936803}. Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:25936803}. Note=Distributed throughout the cell but is enriched in the nucleus. {ECO:0000269|PubMed:25936803}.
Interaction partners:
- Large ribosomal subunit protein uL4A
- Ribosome assembly protein RRB1
- Large ribosomal subunit protein uL4B
- Synchronized import protein 1
- Pre-rRNA-processing protein TSR2
- Ankyrin repeat-containing protein YAR1
- Protein BCP1
- Small ribosomal subunit protein uS3
- 20S rRNA accumulation protein 4
- Triosephosphate isomerase
Sequence:
MSELEATIRQAKEALAENNAKKALKILKPFKSSLKKENANNVILNEVFADAYLDNGQVEKAYPILARACELDPEGQVGGPDKFFTMGQIMGGQDGVSIITRGIMNISNTGGEMLTNVQVEKIVGGLLSVIEIWMTDLCMEPNAEEQCEELIQKAMELTEGKSPETWSTLGSIKISQQKFGEAYEAFSQAWNFFELKKQEIGSGINENGDTTQKAGLQSEYVDLLQPLLSLTKMCLEVGAYEVALKVIAAVRDIDEDNIEGYYLEGFTYYLMSKLEIFKLNNPEVSLRPENIYEFNQLIQEVPLDLSHEPISQLIYDSRLALSFALQAGVNADSKDEIVQELLGGANALLQEIGGPLDPSELTQIKKGDLVNENEDLEELDIEEEYSD
Protein: Homer protein homolog 1 (Homer-1) (Q86YM7)
Organism: Homo sapiens (Human)
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Subcellular location: Cytoplasm {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z214}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. {ECO:0000250}.
Interaction partners:
- Metabotropic glutamate receptor 5
- Metabotropic glutamate receptor 1
- Homer protein homolog 3
- Homer protein homolog 2
- Disks large homolog 4
- Disks large-associated protein 1
- SH3 and multiple ankyrin repeat domains protein 1
- SH3 and multiple ankyrin repeat domains protein 3
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- SH3 and multiple ankyrin repeat domains protein 2
Sequence:
MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS
Protein: Cyclin-F (P51944)
Organism: Mus musculus (Mouse)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). Mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (By similarity). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (By similarity). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (By similarity). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P41002}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P41002}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:P41002}. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Localizes to the nucleus in G2 phase. {ECO:0000250|UniProtKB:P41002}.
Interaction partners:
- S-phase kinase-associated protein 1
- Centriolar coiled-coil protein of 110 kDa
- Cullin-1
- Cell division control protein 6 homolog
- S-phase kinase-associated protein 2
- Cell division cycle protein 20 homolog
- Aurora kinase A
- Serine/threonine-protein kinase PLK1
- Separin
- Ribonucleoside-diphosphate reductase subunit M2
Sequence:
MGSGGVIHCRCAKCFCYPTKRRIKRRPRNLTILSLPEDVLFHILKWLSVGDILAVRAVHSHLKYLVDNHASVWASASFQELWPSPQNLKLFERAAEKGNFEAAVKLGIAYLYNEGLSVSDEACAEVNGLKASRFFSMAERLNTGSEPFIWLFIRPPWSVSGSCCKAVVHDSLRAECQLQRSHKASILHCLGRVLNLFEDEEKRKQARSLLEESSRQGCLISSYLLWESDRKVDMSDPGRCLHSFRKLRDYAAKGCWEAQLALAKACAGGSQLGLEGKACSESVCQLFQASQAVNKQQIFSVQKGLSDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYKLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRVMGEIISALEGKIRIPTVVDYKEVLLTLVPVAPRTQHLCSFLCELTLLHTSLSIYAPARLASAALLLARLMHGQTQPWTTHLWDLTGFSYSDLVPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKCYEEISREEVLSYADLCSTIGVKQESPEPPSFPSSGEIHTFLSSPSGRRSKRKRENSLQEDRGSFVTTPTAELSNQEETLLGSLLDWSLECCSGYEGDQESEGEKEGDVTAPSRLLDVTVVYLNPEEHCCQESSDEEAWPEDKIHPAPGTQAPPASAPRPLLCNRGDRAKDITTSGYSSVSSSSPISSLDGGMGGSPQSTSVLSVGSHSSTKPCHHQAKKSCLQCRPPNSPESGVHQQPVKRQNLSVHSDKDMHLAS
Protein: cGMP-dependent 3',5'-cGMP phosphodiesterase A (EC 3.1.4.35) (Cyclic GMP-binding protein A) (Phosphodiesterase 5) (DdPDE5) (Phosphodiesterase D) (Q8MLZ3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP (Probable). Involved in the degradation of intracellular cGMP, contributes to the control of cGMP signals.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12429831, ECO:0000269|PubMed:12429832, ECO:0000269|PubMed:17040207}.
Interaction partners:
- cGMP-specific 3',5'-cGMP phosphodiesterase 3
- Developmentally-regulated protein kinase 1
- cAMP-dependent protein kinase catalytic subunit
- Probable NADPH:adrenodoxin oxidoreductase, mitochondrial
- Bifunctional protein argC
Sequence:
MMFSKRKSIRFNPEGDYTELPRGGYVVPSKLGGIQFGVPPETIKDSMALKIDVPTIYVFPEELWDRKTGINAAEAEFPAYFNYFILKRKVSFVCTKEQEQRIRIVFQETLLGPPEFNTGIIINSSSSTTDTSKTSPIKKQTSSSSPPLSPQQQQPPPPLVKQPSQQQLEELATMDTCHYHHHHHHQEVNDNDNNNNTTTNNNNIEILEQQQQQQQQQQQQQDEDSTDVDEEFQKEFSSTFPRSEIPNLEKECKYLRTFNSVDELFDFILFDDNGIAKLSDDVEIHFQEDQSLFKVLQFEETGKGNKVQTLVATIPSKILFPDMINSISTINDNKIFDPPTFGITIIGSSHGFDPKKSTTGFVLWINKRGIMVDPPLNSSSFLQSQGVPTRMVDHIILTHCHADHDSGTFQKLLEEYQITVVTTPTILGSFLRKYGALSNLSTDLLRRLFIFRPVMIGEPMIISGAEFRFFYTIHTIPTISFEVFYGGKSIFYSGDTCYDPNRIKDMNKRGIMKTSRMKFFLRPWNHTVVLHEAGVPPIHTPVSVLRALPDEVKNRLYLVHISEHTLPAGSGLKIAKEGVAHTLSLDVMKSSHSEAVDILKLVESVDIFRSIPLTQACEILQTATKRKYSQGSVIIARDTEPDAFYVVASGVVCVNIGELKKNLIVGDYFGEMSLVMGGLRSANVQAVTDVEVLSFNKEDFLSITRNSTESIQFITRLWEMRNEKSWETMSLNSVFSRCTNSQKTAIQSILVRELIKKDETLWCKGEEALFGCLVAEGSFVFKEDDSLESFSQGSFLGDINAMTTQPPSIHKTTVVAKEESVIYKVLSQDLIKFFSNNPGIQLAFLDTIFVDALRDQVQQLVNSKLTY