wanglab/gogpt-training-data huggingface dataset:
Protein: Negative elongation factor E (A0A0A0MSN9)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSSTTSQGGVKRSLSEQPVMDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSISADDDLQESSRRPQRKSLYESDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERSGAHSSASPPRSRSRDRSHERNRDRDRDRERDRDRDRDRDRERDRDRDRDRDRDRERDRDRERDRDRDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIARKQPMLDA
Protein: Heat shock protein SSC1, mitochondrial (Cytoplasmic antigenic protein 6) (mtHSP70) (P83784)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Interaction partners:
- Nucleoporin NSP1
- Nucleoporin
- Heat shock protein 60, mitochondrial
- GrpE protein homolog
- DnaJ homolog 1
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit TIM17
- Hsp70 family ATPase
- Cytochrome c oxidase subunit 4, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM23
Sequence:
MLSARNSLKNISRQFPKALTRAQSTAAAPTGPVIGIDLGTTNSAVAVMEGKTPKILENSEGGRTTPSIVAFTKDGERLVGIPAKRQAVVNPSDTLFATKRLIGRRYEDPEVQRDINQVPYKIVKHGNGDAWLEARGEQYSPQQIGGFILNKMKETAEAALSKKVNSAVVTCPAYFNDAQRQATKDAGKIVGLNVLRVINEPTAAALAYGLEKKDGEVVAVFDLGGGTFDVSILDIGAGVFEVKSTNGDTHLGGEDFDIALVRYIVDAFKKESGIDLEKDKMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHINQKISRAQFEQLVEPLIKKTIEPCKKALKDAGLSTSDVSEVILVGGMSRMPKVVETVKSIFGKEPSKGINPDEAVAMGAAIQGGILAGEVKDVVLLDVTPLSLGIETMGGVFARLISRNTTIPAKKSQIFSTAAAGQTSVEIRVFQGERELTRDNKLIGNFTLSGIPPAPKGVPQIEVTFDIDTDGIIKVSARDKATNKDASITVAGSSGLSDAEIEKMVNDAEKFAESDKARREAIEFANRADQLCNDTENSLNEHKEKLSSESVQKVQDQIQQLREIVLKAQAGEEVSPEELKQKTEELQNEAINLFKDLYKDGGESSGSSEQPKN
Protein: Protein E6 (P06463)
Organism: Human papillomavirus type 18
Function: Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}.
Interaction partners:
Sequence:
MARFEDPTRRPYKLPDLCTELNTSLQDIEITCVYCKTVLELTEVFEFAFKDLFVVYRDSIPHAACHKCIDFYSRIRELRHYSDSVYGDTLEKLTNTGLYNLLIRCLRCQKPLNPAEKLRHLNEKRRFHNIAGHYRGQCHSCCNRARQERLQRRRETQV
Protein: Mlc1p (A0A1D8PSE1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Myosin 1
- Ras GTPase-activating-like protein IQG1
- Myosin 2
- Spa2p
- Cell division control protein 42 homolog
- Formin BNI1
- FK506-binding protein 1
- Ras-related protein SEC4
- Serine/threonine-protein phosphatase
- Glyoxalase 3
Sequence:
MSQNTKTYRDAFALFDKKGTGKIPVEHLGDLLRSVGQNPTLAEIADLQKTIKGSEFDFDTYQEIINRPDGFKPLGLPEDYIKGFQVFDKDHTGYIGVGELRYILTSIGEKLTDSEVDELLKGVNVTSDGNVDYVEFVKSILDQ
Protein: GH05443p (Reversed polarity) (Q7KSE4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Transcription factor glial cells missing
- Protein elav
- Astrocytic leucine-rich repeat molecule
- Sodium/potassium-transporting ATPase subunit beta-2
- G-protein coupled receptor moody
- Bruchpilot, isoform J
Sequence:
MEHDSFDDPIFGEFGGGPLNPLGAKPLMPTTTAMHPVMLGSVHELCSQQQQQQQQQRLPDCNTILPNGGGGGAGSGGAGGSPNYVTKLDFVNKMGCYSPSQKYEYISAPQKLVEQQQQQQHHHQHHQHYTATPPPSHNGILLHKQSSQQQQQQQQQLVGILDYHPLNGKLDYSSSPKDQYEPQQLQHLYGGSPHHLDHLDHGSDGLLQDSSPVMINGGSAGGKLKKPDEMCSQLEAGGAGVTPPSSSSTVVNGTTNGTGNANSSSSAGVGIQGAAGTAGGVAAPAAKKDGSSSKKKGDPNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFAREELAIKLNLSESRVQVWFQNRRAKWRKHEPPRKTGYIKTSTPPTATLNPGTLAPPFTSYPQTTTVTPPGSMDSWTSYQTPYELTPQFSLLSPAASPYGTYSGQYGAYVHESQLFPMRHYEYGSPTRMEMGATTGSVAGNGDESVANGGSYQTAELQTAQQQQLADGTLVTVHAHQQQQQQQQQLNGKYLSAEEAKYVHLQCHQSGGGLELSPGASCHLVEAQGQHYVTTATGGAASAGGTSSDDNDSGGMQTVIKSEEVSQQQQQQQGQSYVLPPFLH
Protein: Elastase (EC 3.4.24.26) (Neutral metalloproteinase) (PAE) (Pseudolysin) [Cleaved into: Pro-elastase] (P14756)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections.
Subcellular location: Secreted {ECO:0000269|PubMed:1597429, ECO:0000269|PubMed:3141383, ECO:0000269|PubMed:9642203}. Note=Secreted in an Xcp-dependent fashion (a type II secretion pathway). {ECO:0000269|PubMed:9642203}.
Interaction partners:
- Protease LasA
- Chitin-binding protein CbpD
- 3-
- HTH-type quorum-sensing regulator RhlR
- Acyl-homoserine-lactone synthase
- Lysyl endopeptidase
- Aminopeptidase
- chitinase
- Putative zinc metalloprotease PA3649
- Serralysin
Sequence:
MKKVSTLDLLFVAIMGVSPAAFAADLIDVSKLPSKAAQGAPGPVTLQAAVGAGGADELKAIRSTTLPNGKQVTRYEQFHNGVRVVGEAITEVKGPGKSVAAQRSGHFVANIAADLPGSTTAAVSAEQVLAQAKSLKAQGRKTENDKVELVIRLGENNIAQLVYNVSYLIPGEGLSRPHFVIDAKTGEVLDQWEGLAHAEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMNSSTDDSKTTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKLYMKVHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQNSGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYMDQPSRDGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSAQNRNYSAADVTRAFSTVGVTCPSAL
Protein: CDK5 regulatory subunit-associated protein 3 (Q99LM2)
Organism: Mus musculus (Mouse)
Function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (By similarity). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (By similarity). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (By similarity). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (By similarity). May also play a role in the rupture of the nuclear envelope during apoptosis (By similarity). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96JB5}. Cytoplasm {ECO:0000269|PubMed:30635284}. Nucleus {ECO:0000250|UniProtKB:Q96JB5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96JB5}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q96JB5}. Note=Tethered to the endoplasmic reticulum membrane as part of the UFM1 ribosome E3 ligase (UREL) complex. Colocalizes and associates with microtubules. {ECO:0000250|UniProtKB:Q96JB5}.
Interaction partners:
- E3 UFM1-protein ligase 1
- DDRGK domain-containing protein 1
- Ufm1-specific protease 2
- Ubiquitin-fold modifier-conjugating enzyme 1
- Ubiquitin-like modifier-activating enzyme 5
- Ubiquitin-fold modifier 1
- Cyclin-dependent kinase 5
Sequence:
MQDHQHVPIDIQTSKLLDWLVDRRHCNLKWQSLVLTIREKINTAIQDMPESQEIAQLLSGSYIHYFHCLRIVDLLKGTEASTKNIFGRYSSQRMKDWQEIVSLYEKDNTYLVELCSLLVRNVSYEIPSLKKQIAKCQQLQQEYSRKEEEGQAGAAEMREQFYHSCKQYGITGDNVRRELLALVKDLPSQLAEIGAGAQSLGEAIDLYQACVEFVCDSPTEQVLPMLRYVQKKGNSTVYEWRTGTEPSVVERPQLEEPPEQVQEDEIDWGDFGVEAVSDSGIVAETPGIDWGISLESEAKDAGADKIDWGDDAAAASEITVLETGTEAPEGVARGSDALTLLEYPETRNQFIDELMELEIFLSQRAVEMSEEADILSVSQFQLAPAILQGQTKEKMLSLVSTLQQLIGRLTSLRMQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVEKQQEALQEQAALEPKLDLLLEKTRELQKLIEADISKRYSGRPVNLMGTSL
Protein: Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase) (O35543)
Organism: Rattus norvegicus (Rat)
Function: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
Subcellular location: Cytoplasm.
Interaction partners:
- Prostaglandin-H2 D-isomerase
- Glutathione S-transferase theta-1
- Prostaglandin E synthase
- Thromboxane-A synthase
- Prostaglandin E synthase 3
- Prostaglandin G/H synthase 1
- Prostacyclin synthase
- Prostaglandin G/H synthase 2
- Prostaglandin E synthase 2
- Aldo-keto reductase family 1 member C15
Sequence:
MPNYKLLYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPKIKPTLPFGKIPVLEVEGLTLHQSLAIARYLTKNTDLAGKTELEQCQVDAVVDTLDDFMSLFPWAEENQDLKERTFNDLLTRQAPHLLKDLDTYLGDKEWFIGNYVTWADFYWDICSTTLLVLKPDLLGIYPRLVSLRNKVQAIPAISAWILKRPQTKL
Protein: Protein DOG1-like 4 (Q84JC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Berberine bridge enzyme-like 5
- DNA glycosylase/AP lyase ROS1
- Dehydration-responsive element-binding protein 2G
- Heat stress transcription factor A-9
Sequence:
MSKMRNLVEEKFLEFYESWVIQLELYLHQLLIAHNNNTMSETELRHLISKLTTHHKAYYTAKWAAIREDVLAFFGSVWLNPLENACSWLTGWKPSMVFRMVDRLRKSRVVLVEAQVKKLEELRVKTKFDEQKIEREMERYQVAMADRKMVELARLGCHVGGESVMVVEAAVRGLSMGLEKMVKAADCVRLKTLKGILDILTPPQCVEFLAAAATFQVQLRRWGNRRHYVTHS
Protein: Integrin subunit alpha 8 (F7F1E3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Interaction partners:
Sequence:
MSARTHRGPPENWAPPFACLCCVSAVLGMLWSPVSLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNVDPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSVADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSLQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQVSALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNARGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPATWWGHSKFIQTENSEEEFQTYGGDLLVGAFGEGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSLRVCASIAGQSISNTVALMAEVQLDFLKQKGAIKRTLFLHNHQSHLIFPFVMRQQKSLHCQDFMVYLRDETEFRDKLSPINVSLNYSLDDSTFEDGLEVKPILNHYRENVVTEQAHILVDCGEDNLCVPDLRLSARPDKQEIIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGLRLLSCEYKMENVTRMVVCDLGNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSVQINVTAVAQVEIRGVSHPPQIVLPIHNWEPAEEPHKEEEVGPLVEHIYELHNIGPSTISDSILEVGWPFSAREEFLLYVFHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQPHRQSPAKILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKIPYKEQPAKLPAGSTAIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA
Protein: Platelet receptor for type III collagen (Q8NFD8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
DARKSEVQKKKKKKINWASLHMPVIPATLEAEAGELLEPKRCRFAVSRDHCHCTLAWKTARLHLKKKKKKELNLVYTTVMNTNRIFKMIFSRVANVKNFVSLSKLCIACDRKSSSNQPKHISDLLCHIREQSRDWLGFVLNFQWNIIRAQFVHVHFISLSEFHFRALLSTWLQNSIQEGPIAKTFSDLSAYREQQNFLFLCPNKSHSVILCSLIGHMYISKPLTILRKMSHVGLTYNYLIRRPRTRSVRKLILRGRLHAFSRKSNVSLEKMNNENPLKSVSRIIFHDSTGLNACDIYLNAASNYRNRYRIYDTACGTFVIIYLNFVNMHPNFTHTNYLNVEYLLVEIWWVRSLL
Protein: Vacuolar protein sorting-associated protein 18 homolog (Q8R307)
Organism: Mus musculus (Mouse)
Function: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes. Involved in dendrite development of Pukinje cells.
Subcellular location: Late endosome membrane {ECO:0000250|UniProtKB:Q9P253}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9P253}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9P253}. Lysosome membrane {ECO:0000250|UniProtKB:Q9P253}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9P253}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9P253}. Early endosome {ECO:0000250|UniProtKB:Q9P253}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000305}. Note=Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
Interaction partners:
- Vacuolar protein sorting-associated protein 33A
- Transforming growth factor-beta receptor-associated protein 1
- Vacuolar protein sorting-associated protein 41 homolog
- Vam6/Vps39-like protein
- Vacuolar protein sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 8 homolog
- Vacuolar fusion protein CCZ1 homolog
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Vacuolar protein sorting-associated protein 33B
Sequence:
MASILDEYEDSLSRSAVLQTGCPSVGIPHSGYVSAHLEKEVPIFTKQRVDFTPSERITSLVVSCNQLCMSLGKDTLLRIDLGKASEPNRVELGRKDDAKVHKMFLDHTGSHLLVALSSTEVLYMNRNGQKARPLARWKGQLVESVGWNKAMGNESSTGPILVGTAQGQIFEAELSASEGGLFGPAPDLYFRPLYVLNEEGGPAPVCSLEAERGPDGRGFVIATTRQRLFQFIGRAVEDTEAQGFAGLFAAYTDHPPPFREFPSNLGYSELAFYTPKLRSAPRAFAWMMGDGVLYGSLDCGRPDSLLSEERVWEYPAGVGPGANPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFLEKFGPLRHMVKDSSTGHLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFRQHRYLESARCYALTQSYFEEIALKFLEARQEEALAEFLQRKLAGLKPTERTQATLLTTWLTELYLSRLGALQGDPDALTLYRDTRECFRTFLSSPRHKEWLFASRASIHELLASHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSPILIRHIPRQLVDAWIEMGSRLDARQLIPALVNYSQGGEAQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGQPASLLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVLELYEEAVDLALQVDVDLAKQCADLPEEDEELRKKLWLKIARHVVQEEEDVQTAMACLASCPLLKIEDVLPFFPDFVTIDHFKEAICSSLKAYNHHIQELQREMEEATASAQRIRRDLQELRGRYGTVEPQDKCSTCDFPLLNRPFYLFLCGHMFHADCLLQAVRPGLPAYKQARLEELQRKLGAAPPPTKGSVKAKEAEAGAAAVGPSREQLKADLDELVAAECVYCGELMIRSIDRPFIDPQRYEEEHLSWL
Protein: Kelch protein K13 (Q8IDQ2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Kinesin-like protein
- Cullin-like protein, putative
- Cullin-1, putative
- Leucine-rich repeat protein
Sequence:
MEGEKVKTKANSISNFSMTYDRESGGNSNSDDKSGSSSENDSNSFMNLTSDKNEKTENNSFLLNNSSYGNVKDSLLESIDMSVLDSNFDSKKDFLPSNLSRTFNNMSKDNIGNKYLNKLLNKKKDTITNENNNINHNNNNNNLTANNITNNLINNNMNSPSIMNTNKKENFLDAANLINDDSGLNNLKKFSTVNNVNDTYEKKIIETELSDASDFENMVGDLRITFINWLKKTQMNFIREKDKLFKDKKELEMERVRLYKELENRKNIEEQKLHDERKKLDIDISNGYKQIKKEKEEHRKRFDEERLRFLQEIDKIKLVLYLEKEKYYQEYKNFENDKKKIVDANIATETMIDINVGGAIFETSRHTLTQQKDSFIEKLLSGRHHVTRDKQGRIFLDRDSELFRIILNFLRNPLTIPIPKDLSESEALLKEAEFYGIKFLPFPLVFCIGGFDGVEYLNSMELLDISQQCWRMCTPMSTKKAYFGSAVLNNFLYVFGGNNYDYKALFETEVYDRLRDVWYVSSNLNIPRRNNCGVTSNGRIYCIGGYDGSSIIPNVEAYDHRMKAWVEVAPLNTPRSSAMCVAFDNKIYVIGGTNGERLNSIEVYEEKMNKWEQFPYALLEARSSGAAFNYLNQIYVVGGIDNEHNILDSVEQYQPFNKRWQFLNGVPEKKMNFGAATLSDSYIITGGENGEVLNSCHFFSPDTNEWQLGPSLLVPRFGHSVLIANI
Protein: Progonadoliberin-1 (Progonadoliberin I) [Cleaved into: Gonadoliberin-1 (Gonadoliberin I) (Gonadotropin-releasing hormone I) (GnRH-I) (Luliberin I) (Luteinizing hormone-releasing hormone I) (LH-RH I); Prolactin release-inhibiting factor 1 (Prolactin release-inhibiting factor I)] (P07490)
Organism: Rattus norvegicus (Rat)
Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular location: Secreted.
Interaction partners:
- Gonadotropin-releasing hormone receptor
- RAC-alpha serine/threonine-protein kinase
- Mitogen-activated protein kinase 3
- RAC-gamma serine/threonine-protein kinase
- RAC-beta serine/threonine-protein kinase
- Mitogen-activated protein kinase 1
- KiSS-1 receptor
- Follitropin subunit beta
- Neuromedin-K receptor
- Tachykinin-3
Sequence:
METIPKLMAAVVLLTVCLEGCSSQHWSYGLRPGGKRNTEHLVDSFQEMGKEEDQMAEPQNFECTVHWPRSPLRDLRGALERLIEEEAGQKKM
Protein: Ionotropic receptor 40a (Q9V9N1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in humidity (hygrosensation). Together with Ir25a and Ir93a, mediates the response of the hygrosensory sacculus neurons to changes in relative humidity and is required for dry detection behavior.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ionotropic receptor 93a
- Ionotropic receptor 21a
- Ionotropic receptor 41a
- Ionotropic receptor 68a, isoform A
- Ionotropic receptor 25a
- Ionotropic receptor 64a
- Ionotropic receptor 8a
- IP13856p
- Ionotropic receptor 31a, isoform C
- Ionotropic receptor 60a
Sequence:
MHKFLALGLLPYLLGLLNSTRLTFIGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVYLDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSFFTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKLDQARLWMLCSRLQWIRYDRKV
Protein: FI16515p1 (Syntrophin-like 2, isoform E) (A1ZAH3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Dystrobrevin, isoform F
- EG:4F1.1 protein
- Dystrophin, isoforms A/C/F/G/H
- Sarcoglycan alpha, isoform C
- IP02644p
- Dystroglycan 1
- Beta-sarcoglycan
Sequence:
MISGIMKLSDTMATPIEEKLDQNLKVRTGMVHVSDGKSRPEPLRLNLTMELLSLQKLEVVTPSSCHPNGPPMESKERMVQITRQKQGGLGLSIKGGAEHKLPILISRIYKDQAADITGQLFVGDAIIKVNGEYITACPHDDAVNILRNAGDIVVLTVKHYRAATPFLQKQLTKDTPDSDNDVTCAELKADEGYKSSVNSGTISRSCSRPMSICSEPEKRWTDVVAVPLMMAYVTRYIYGTDKLRQNAFEVRGLNGISTGVIHCDELAILSQWLKLITDNVVGLTHLQMKLYNRNFAVGERIEYMGWVNEGVINNNISWQSYKPRFLLLKGTEVMLFETPPLNVAGISKALVVYKVYQTMFRIVKESETVDSRQHCFLLQSSGHEPRYLSVETRQELLRIENSWNAAIVTSVIKLGRKTFAVSHHGKSGGLTLDWQAGFSLTEGAESATVWQYKFSQLRGSSDDGKSKLKLHFQDHDSRAIETKELECQVLQSLLFCMHAFLTAKVASVDPAFLSSIQQT
Protein: Cyclin-T1 (CycT1) (Cyclin-T) (O60563)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II.
Subcellular location: Nucleus {ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:29849146}.
Interaction partners:
- AF4/FMR2 family member 1
- Bromodomain-containing protein 4
- AF4/FMR2 family member 4
- Protein ENL
- Cyclin-dependent kinase 9
- Protein HEXIM1
- RNA polymerase II elongation factor ELL
- Protein AF-9
- La-related protein 7
- RNA polymerase II elongation factor ELL2
Sequence:
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
Protein: Kinesin-like protein KIN-1 (AtKIN-1) (AtPSS1) (Pollen semi-sterility protein 1) (Q8GW44)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Kinesin-like motor protein that promotes synapsis and is required for proper crossover distribution in meiosis. Plays a role in the nuclear division cycles during megagametogenesis.
Interaction partners:
- Protein COLD-REGULATED 15A, chloroplastic
- Ras-related protein RABC1
- Low-temperature-induced 78 kDa protein
- Dehydrin COR47
- SUN domain-containing protein 2
- SUN domain-containing protein 1
- Dehydration-responsive element-binding protein 2A
- Zinc finger protein WIP3
- Kinesin-like protein KIN-10A
- Zinc finger protein WIP2
Sequence:
MSNVTVCARFRPRSSKEMRDPSRDGVCARPIDAETFVFQDDKEDEFTFSLDRVFYEDSTQAAVYEFLALPIMRDAVNGINGTIITYGQTGAGKTYSMEGPGIQDCDEHNKGLLPRVVHGMFEQISSSNDIARYTVKLSMVEIYMEKVRDLLDLSKANIQIKENKTQGILLSGVTEVPVSDSVEALQHLCTGLANRAVGETQMNMSSSRSHCAYLFTIQQDSVKDKRVKTGKLILVDLAGSEKADKTGAEGRVLEEAKTINKSLSALGNVINALTSGPSSKGNHIPYRDSKLTRILQDALGGNSRMALLCCCSPSTLNASETLSTLRFGMRAKHIKASPRASEVKSAKAQEEPSSVTKDEKCGRILEKMKERMSNEDIKMLEDVFIQEGIIFSLDSMAEVETVYEDIVSKTIQSLQQAVDELQQKVKKLEAENIGIQEQALRNHEPGSVGKMSRFISSWYASFFTS
Protein: FI17817p1 (Transport and golgi organization 5, isoform A) (Transport and golgi organization 5, isoform C) (Transport and golgi organization 5, isoform D) (Transport and golgi organization 5, isoform E) (Transport and golgi organization 5, isoform F) (Q9W2S1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Autophagy-related protein 13 homolog
- Beclin-1-like protein
- Autophagy-related protein 101
Sequence:
MSQHSKKETTSSSGSHAAQSNRHNNIGGGGGNGNSNSISGSSNNKSHKRQAANGSLKSPLLTITNINSHSQKGALKSPVSKVKQSSNSSSSNSNSKTLSGSSMQETGSSATSLLAAGGKAKKNQKDKQRERERLERGQLVLWRRPLQTTKYCGLELFTLLRTWSTRLLQQRLLLATLIVLSIVFSVIYKIDGPHQLAIEFVRRNTWFFVYWLGLGVLSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSLRFPQPPYPDDIICPEEPYDKHVPNIWSIMSKVRLEAFLWGAGTALGELPPYFMAKAARLSGYDPEDAEELAEFEALNAKRHQKNLSMMDRGKLFMERVVERVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAVIKMHIQKIFVIIAFNETLIERAVDLLATLPVLGHKLQEPFKSFLKNQKQRLHRQQRGAAGATTGAGDSGNLLSRIFETFVIGMVCYFVVSIVNSLAQSYHKRLHKKPASPVAATTPTRQSTGASKKAGKQKALRD