wanglab/gogpt-training-data huggingface dataset:
Protein: Very long chain fatty acid elongase 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Elongation of very long chain fatty acids protein 6) (Fatty acid elongase 2) (rELO2) (Fatty acyl-CoA elongase) (Long-chain fatty-acyl elongase) (Very long chain 3-ketoacyl-CoA synthase 6) (Very long chain 3-oxoacyl-CoA synthase 6) (Q920L6)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03206}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03206}.
Interaction partners:
- Very-long-chain 3-oxoacyl-CoA reductase
- Very long chain fatty acid elongase 5
- Fatty acid synthase
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- Acetyl-CoA carboxylase 1
- Acyl-CoA desaturase 1
- ATP-citrate synthase
- Peroxisome proliferator-activated receptor alpha
- Sterol regulatory element-binding protein 2
- Sterol regulatory element-binding protein 1
Sequence:
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFNWMQHDNDQCYSHFQNIFWSSLMYLSYLLLFCHFFFEAYIGKVKKATKAE
Protein: Mitotic spindle assembly checkpoint protein 1 (Q54JX0)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSQEDDDNILLSTSTLLKSQDTFRGKINTNSSLYKSLNSNNNNFNFNQSINNNNNNNNNNNKAIFLDNKEFNSLSKDIEEYLNSIENNNSDNDDDDDDDEQNSTVNEINNDLPITFLSDANEAIKKQQLYIQQLERQLKQDKRIGDNLLQQSLELSSTEKELSELKVKFNDIERTNKFLLTKTAEARLDLENSEKINQTKIANKNLEIEGLSKKIKFLSNSEKELEDKLKEMDNKYLELERNTQLKIRAIEKEKTNCRTEIVELKHKNSNQNDLTSIQKLKDSEIQHLKSINKKLEEQINHQKQTLDSTLKQLSEKDKQLDTFKNIITSPPPPSSSSSSLSSASASLKNSEIETLNQSLKSEINYFKKINKEQKDEINRLNKIFEGVGNLEMIKQQNENMKEKIKRLEPLIEKYNRLQVEHNQLINEKNQMELTFGSIDKQQSTQQLQQKIIQLENDNQTLIGKIGEITANWKLMESRNQDYSIRIQQEKDSLNEKLTKINELTEKIKRLEKLNYLLNRERDNIKNILDTYDDNQQPQQLQDDDNNNNNNNNNNNNESGDTKRRIEIINELERSLKEKNILIQEYEYKLDCNNNSNNVNGDFSSINYKEECKRLNKEIEKLLQENALLEARLGKGEFDPLKTKVLHFSNNPSSLILNQQQQQEESNNNNINNNINNDKNNNNSIQIDKKLIEENHRLLIQINDGEKKMDRLKQIFKQKINEFREAVYALLGFKIDVDTNNRYKLQSMYAERESDFLMFQQSPPTQQSNNKGRIQMELLETEFTRNLDKEIKAYLFACKSIPSFLSQVTIELFSKQTFHP
Protein: H/ACA ribonucleoprotein complex subunit 3-like protein (Nucleolar protein 10) (Q93XX8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Putative H/ACA ribonucleoprotein complex subunit 1-like protein 1
- H/ACA ribonucleoprotein complex subunit 4
- H/ACA ribonucleoprotein complex subunit 1-like protein 2
- H/ACA ribonucleoprotein complex subunit 2-like protein
- Telomerase reverse transcriptase
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein
- At4g22380
- Nucleolar protein 56
- At4g01790
Sequence:
MYLQCYINEKGEKVYTTKKESPLGLATESAHPARFSPDDKYSKQRVLLKKRFGLLPTQNAPLQY
Protein: RUNX family transcription factor 2 (E1BAC1)
Organism: Bos taurus (Bovine)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRNPRQAQSSPPWSYDQSYPSYLSQMTPPSIHSTTPLSSTRGTGLPAITDVPRRISGSPRRT
Protein: Fos-related antigen 1 (FRA-1) (P48755)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P51145}.
Interaction partners:
- Transcription factor JunB
- Transcription factor Jun
- Transcription factor JunD
- Fos-related antigen 2
- Protein FosB
- Protein c-Fos
- Mitogen-activated protein kinase 14
- Stress-activated protein kinase JNK
- Transcription factor Maf
- Mitogen-activated protein kinase 9
Sequence:
MYRDYGEPGPSSGAGSPYGRPAQPPQAQAQTAQQQKFHLVPSIDSSSQELHWMVQPHFLGPTGYPRPLAYPQYSPPQPRPGVIRALGPPPGVRRRPCEQISPEEEERRRVRRERNKLAAAKCRNRRKELTDFLQAETDKLEDEKSGLQREIEELQKQKERLELVLEAHRPICKIPEGDKKDPGGSGSTSGASSPPAPGRPVPCISLSPGPVLEPEALHTPTLMTTPSLTPFTPSLVFTYPSTPEPCSSAHRKSSSSSGDPSSDPLGSPTLLAL
Protein: Transforming acidic coiled-coil protein, isoform J (A0A0B4JCV4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MEFDDAENGLGMGFGGRGVLREINKNDGGIKLSPLAVKPSPKPTSMDQQKAMAAALGHQTAVPGGLKPEDDLVPKFGGLPEFDETQIPELAPLSTDMDTQLKSNHSDSDVFVECLSLHSERYTGDRSELEAYSSALNDVLEQQLSMTSVSTLGAEFNDPLAVSQHNNVSYEAMDVDDLNETMEMLKDVLNAEDRHLMQTHILSVTQSKPENNFVHYHPNQEQNRVELDQLAKHSKPNSDAKESESLVESVLSEESGTQSFEPKLTLSALDSTKDLAKHQEEMQTNTKDIFQKEKHHPVSSAQVKDAQNPKEPEKALNLKEASSELSTKSAKSLEYPNQEKQFSVAVESMERPCTAISLEQNASPAMEATEDRTVEELDQMDVDESMKVDDATVLNSCRQEQINAHSPVSSKFFLKLCVQNDTDCQDNKMDQKTAGKESALKMTEIELPVESVPSASLSPPTPALQAKIIELSLSPPIPTHRPKTAEELEFLALRELPLPDGVSTAGKVECKQLSHGLVPIVAVLPTPLYLDLKGNTTTASLPEPTSPSFPIKEPAEKQSHFPRSPRAQLEQKDMPYLEEAVVERSSHRKQSDFGVIAKSPIVFELTQPSPEKQHLNETLPMSEISPTSSNMTFDSGSITEDKSQKGTENIEPSSTLAVSLGSVDDKQRRTFSVVQPTKEEEEAKSRRTFCMENENPRRTFCMQQNASPAVEATEDTGADEVMDVDISMRADEVAVMKSHQQTWKERQAPISNSPPIPTHQRLNRPPEAISPVSPLGNGTVVLEEQTLSAKEQATLSASDEKDDVFLEHFGAISPVSDDMFKTSSASNNQAKFRVNADEETGGKGASAMIRKRSGTAGEQEEIFDAEFHDGVNNQNRSNSVPIDRSSLLLKFDPLLGAPVPVNHPNQQEQALQNILGSNQHQNRLLSPTLEEHETSDGNQSFGVISSAKDTAKKWDFKPPVDRTKKHVKMSVDVIDNDCNKTFDNSNTNTEDKTHNYNDMDELEKKIKNEVTRSEDIEKKLKEGELREEALIKRITEKDKTNAKLNGVIEAYEKAIAELISEKEQQAQLHERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQLEIANKKLDTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICEELIYGKGQGGSS
Protein: Vacuolar iron transporter 1 (OsVIT1) (Q6MWE5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Vacuolar iron transporter involved in the transfer of iron ions from the cytosol to the vacuole for intracellular iron storage. Vacuolar iron storage is required for seed embryo and seedling development (Probable). May be involved in the regulation of iron translocation between flag leaves and seeds (Probable). Can transport zinc ions from the cytosol to the vacuole.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:22731699}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the tonoplast. {ECO:0000269|PubMed:22731699}.
Interaction partners:
- Glutamate synthase 2, chloroplastic
- Ferredoxin-dependent glutamate synthase, chloroplastic
- glutamate synthase
- Glutamate synthase 1, chloroplastic
- Guanylate kinase 1
- Guanylate kinase 2, chloroplastic/mitochondrial
Sequence:
MAAATDGGGLPLLADKAASHSHHHHPERHFTSGEVVRDVIMGVSDGLTVPFALAAGLSGASAPSSLVLTAGLAEVAAGAISMGLGGYLAAKSEADHYQREMKREQEEIIAVPDTEAAEIGEIMSQYGLEPHEYGPVVDGLRRNPQAWLDFMMRFELGLEKPDPKRAIQSALTIALSYVIGGLVPLLPYMFISTAQNAMLTSVGVTLVALLFFGYIKGRFTGNRPFLSAVQTAIIGALASAAAYGMAKAVQTR
Protein: Syntaxin-7A (Q54JY7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for fusion of late endosomes with lysosomes and homotypic lysosomal fusion. May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:10978342, ECO:0000269|PubMed:12175335}; Single-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:10978342, ECO:0000269|PubMed:12175335}.
Interaction partners:
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Vesicle-associated membrane protein 7A
- Syntaxin-8A
- Probable syntaxin-8B
- Alpha-soluble NSF attachment protein
- Vesicle-fusing ATPase
- t-SNARE coiled-coil homology domain-containing protein
- Vesicle-associated membrane protein 7B
- Golgi SNAP receptor complex member 1
- Vesicle-trafficking protein SEC22b
Sequence:
MYNNNNNFGGGGYNQGGGYNSGGYNNNGGGYNNNNGGYNNNNNNNGGYNNNRPQQQQQQQQQYVNNNNNSFDNNGYGGDDDVTNNSDYQSTTRNIQQIQNAVQILTKLVQLLGTPKDSMDTREKIRNCVDSTTHLISSESGKVKNLTSLASRSRDSKNKLLYQKLVKEFNNCLQQFKDIAQVATKKEKTTPLPVAPDHQQPTTFGRNNNSNNNNQNNHFLNNQQPYYDDDNREDEHQSLMESSRRQQLAQIEAEREYQNSIIQERDEGIRKIEQSIVEINEIFVDLSGLVAEQGVMINTIEASLESTTINTKEGVNHLREASKNQKSSRNKMCWIVLILLIVCAVLGVILFFTLRK
Protein: DNA binding protein (Q9LHI5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MELEFKCSDVGVWKEALSSYDSRIESLNKPELVSLDQFYRIKLPCLLHDRDPNPYLTTSELSQLMKWKLSRGKWRPRLLDFVSSLDDSVVKSASEKAFKSLPDISKAVKELTVLKGVGAATASAVLAAYAPDIAPFMSDEAMEVALGNSKDYSLKQYLLFATKLQDKAKELKLKGEWDGPSDIERALWSCTVRAKSQPEKSSSGKKRKRKCSRMFYQNAEYLAESYNLKGKNGYFTFSDIFQINIEGYEGRVIGGEKQNRGYVVSHLTKLILACIIADRLLLVTEFGHLSIP
Protein: Phospholipid/glycerol acyltransferase domain-containing protein (G8JY39)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MVYLPLHRSHLDYLLITWCNWHFGLKLPHIASGDNLNLSGLGWLLRATGAFFIRRRVDPDDERGKDQLYRAILHSYIEQVLSKDMPIEFFLEGTRSRFGKALTPKNGLISNVVEAVQHGFIKDCYLVPVSYTYDAVVEGIFLHELMGIPKVRESVLGVFRGIFSGFSKSKQCGVVRMHYGRPIRLTEYLATITASLSSNHRTRPVRMTKLSTSFSYRELVPWHRTHSETVDDRTMIRAIGFHVVYEAQMMCSISPVAVVSCLLLAKWRGKVSRSTFERDCEWLCEKIIAEGGDVVGYQSKKTKGSALVKYAFEKLESCVEVTDEYVSPKESHSSFITLAYNKNSVICRFSIKSVIALTIVSRPSGTKLSIDQIVEDALSLCDWLQFEFMFCRPCDSLRELVHNVLGQKEWSDPIHGFLRSEIEDDGFLDAGGALNSGTLRVRDAKSRETLQFFANLVRPFVQSLYLISSFVVSEKCPTEPTSDNNIIRQLCQQSLAGDIDLPFAPLLESINSDSFKNALRVLKDKGLLQRSTPNSTARSGNSRLAELISNLERVLEVK
Protein: Chondroitin sulfate glucuronyltransferase (EC 2.4.1.226) (CSGlcA-T) (Chondroitin glucuronyltransferase) (Chondroitin polymerizing factor 2) (ChPF-2) (Chondroitin synthase 3) (ChSy-3) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) (Q9P2E5)
Organism: Homo sapiens (Human)
Function: Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Chondroitin sulfate N-acetylgalactosaminyltransferase 2
- Chondroitin sulfate N-acetylgalactosaminyltransferase 1
- Chondroitin sulfate synthase 2
- Chondroitin sulfate synthase 3
- Chondroitin sulfate synthase 1
Sequence:
MRLSSLLALLRPALPLILGLSLGCSLSLLRVSWIQGEGEDPCVEAVGERGGPQNPDSRARLDQSDEDFKPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARAPAGMQVVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDLYLGRAEEFIGAGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDSLGVGCVSQHQGQQYRSFELAKNRDPEKEGSSAFLSAFAVHPVSEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTVLTPEGEAGLSWPVGLPAPFTPHSRFEVLGWDYFTEQHTFSCADGAPKCPLQGASRADVGDALETALEQLNRRYQPRLRFQKQRLLNGYRRFDPARGMEYTLDLLLECVTQRGHRRALARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLLVAEAAAAPAFLEAFAANVLEPREHALLTLLLVYGPREGGRGAPDPFLGVKAAAAELERRYPGTRLAWLAVRAEAPSQVRLMDVVSKKHPVDTLFFLTTVWTRPGPEVLNRCRMNAISGWQAFFPVHFQEFNPALSPQRSPPGPPGAGPDPPSPPGADPSRGAPIGGRFDRQASAEGCFYNADYLAARARLAGELAGQEEEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLGGRAQLAMALFEQEQANST
Protein: PRB1 protein (A5D903)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLLILLSVALLALSSAQNLNEDVSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGKPQGPPPQGGNKPQGPLPPGKPQGPPAQGGSKSQSARAPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ
Protein: Putative protease AXL1 (EC 3.4.24.-) (P40851)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable protease. Involved in axial budding.
Subcellular location: Bud neck {ECO:0000269|PubMed:12176366}. Note=Mother-bud neck and division site remnants of haploid cells.
Interaction partners:
- Bud site selection protein 4
- CAAX prenyl protease 1
- Axial budding pattern protein 2
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Protein-S-isoprenylcysteine O-methyltransferase
- Bud site selection protein 3
- CAAX prenyl protease 2
- Bud site selection protein 5
- Alpha-factor-transporting ATPase
- Protein farnesyltransferase subunit beta
Sequence:
MSLREVTNYEVSFYIPLSYSNRTHKVCKLPNGILALIISDPTDTSSSCSLTVCTGSHNDPKDIAGLAHLCEHMILSAGSKKYPDPGLFHTLIAKNNGSQNAFTTGEQTTFYFELPNTQNNGEFTFESILDVFASFFKEPLFNPLLISKEIYAIQSEHEGNISSTTKIFYHAARILANPDHPFSRFSTGNIHSLSSIPQLKKIKLKSSLNTYFENNFFGENITLCIRGPQSVNILTKLALSKFGDIKPKSAVKERSISIRTRSFRRSKSLKKRQDSSKNDYSDLKTFKILNTTWEKKYKNTMCFQQFPECNSIFINSNKVPIMRLLFPVSDKNTRFTKDDIKIYSHLWCELFGDESPGSLSYYLASKGWLTGCFAFTSEFAIGDIGLILELELTNSGWENIKRITTIVLNRLLPSFYVMNIDYLITFLKEQNLIDLVSFLYQSSEDLPMEECSKLSGILQDDLECLTPPNIFKGFKSLIEIDDPNIEKYENTKANIQWWTGQAIKFQNFLKSFMNHDNMRLLLLGNIKSGNIFDKMKNKSDICTDFFYEFEYYTANVHLASDNKFHSNSSYEFNFPTGNLFLPDCVSDPLKLQQLFLECSLKSKFATLRPQIYSEPTRTKPQLVSENQNYEMWILKEDPNFASDNKSVVSFEVLGLGIKPSPEATIHLEVLAQALFIITSSFLYPALRIGYTYEIASSSKGNVTLRFTISGFPEGVFTIVKTFVDTLKLIATDPTFLSKDTLRKARILVRNKYKNASSDNCVKLASVGLLIVLEKYIWTLEDRINALELTELESFEKFCFLFWRNPKHLVLFMQGSLEYADAINRYLNNNFTQHLKISNEGSKPTIRLYPPPSTKDLDQGTNAFISYNGHQDDPNNSIVYFIQTAQRDDIKNLTLTFLTEYLFSLTLVPDLRNKKQIGYIVLGGLRVLTDTVGIHITVMSGSSGHNLETRINEYLSYLQLQVLNRFTEFDFRRILLEPFLNLLKQNSTKQFEGSAGPVDLLNEIVANVQNGDNYTLNNKQMRQHRKVRNKIAEGRLNFQEDHEMIDISFLQKLTLKKYLAFFESKISIYSAQRSKLSIMITSPMAEKEIASRKMFLQLEAFLKINGFAIKNEDLKKIVEHSKGNPILLVKNLFTYFRRRNEVFKLGTVVLQEILKIIGMNLKQRYGSILGFSSQDGEGQEIEKFWNNDTSPIVPLQELPEPNFFRKAAF
Protein: Antigenic leucine-rich repeat protein (A0A3N4B5W9)
Organism: Yersinia pestis
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MYLSNITSNVSMPNIGPDREIHADRPAATALTPADYHAIWEKWENDPRTVAGEQRGQAVARMKECLENNAERLNLSSLDLTSLPDTLPPCNELNIICNNLTELPTTLPDNLQTLKASYNQLRTLPNTLPASLLSLKVHMNELERLPEPLPEGLKTLDVGCNTSLQLPSRLPPVLESLDISNCNLTELPTLPNSLKELDAHGNQLRILPDTLPISLLRLNVAYNQLTALPENLPGSLRCIYTEYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTKPNYQGPRIS
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (Q8I3W6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Suppressor of kinetochore protein 1, putative
- DNA repair protein RAD51 homolog
- 3'-5' exonuclease
- Uncharacterized protein
- DNA repair and recombination protein RAD54, putative
- Small ubiquitin-related modifier
- Meiotic recombination protein DMC1, putative
- Proliferating cell nuclear antigen 2
- Proliferating cell nuclear antigen 1
- DNA 3'-5' helicase
Sequence:
MNEDEVGKNICSASVEMKKKKSKSTYILKNILFNNFSEEQQRIIEIPMNVNLCIIACPGSGKTSTLTARIIKSIIEEKQSIVCITFTNYAASDLKDKIMKKINCLIDICVDNKINQKLFNNKNNKINFSLKNKCTLNNKMNKSIFKVLNTVMFIGTIHSFCRYILYKYKGTFKILTDFINTNIIKLAFNNFYSSMMSKTKGTQPGFSTILERKSNKASTQNCDPDKINTHNNDDNINNKNDYINNKNKNDYNNINNYDNINNYDNINNDDNINNDDNINNDDNINNDDNINNDDDINNCGNCNQPKGIPSQLAYFINCMKNAEIKEDEEKEFYEEEHDIQNDILNNDDNNNDEDDDDDDEFYNYLYNFKHSYEQTNDYFANEQVQSVLKKKNIIFLKKKIKLMKYIELYNIKIEINDVEKMFYEEYKKIFKKAKNIYYDFDDLLIETYRLMKDNADIRNKILEEWNYVFCDEFQDTNTTQFNILQFFVNHNVPSTLDQSIYTSGNLENKDIKDNHNISMSTYKSKQYSHSVQNFFNEHKVDQQLCDQIYFDKHCNNILMQNKNQQATHKHSEEEEEQEEEKKKNKKTKKTNTFINQQKIKTQTVLSYKQDEMSSSASSTYSYVKIEKEKKKYALNKIDDTYYNKKNIYSNNDEILDIENEQTFFNNNCNEKNKTKKKCNLKDRSLTVIGDDDQSIYSFRGAHINVFYKFLKDCNCLLFKLNNNFRSTREIVRVSQNLIINNRTCRIQKQLYTNNVQGNKIQFHAFKTPSDEISYILSEIIYLKKNYNYKYGDFVILCRTNKTLKETLKSIHNVDIKKKAYKYLINKFLNDKQNHLIKQKEYNTKIIQNNNTNHVYKNSPIGNDEINIYENNQKYEEYMKEFHNIFDIDTFKIPIKELNKKKAFFGSKEIIELITFLRFLLNVDDNIIFKKAFKIIKNMKNTKQIIDKLTSCQTNQHLSNILMEYSHDIVHIKTQQNKIHKHERINNDKLSLFSCVQSITHLFILKKRQTINKESSLRVLNIFTEKELKSIVDFFFCINYFLKFAAHINSVYYLVIEVLKKTNFLKRLQAKIQKKTDEEKKENNIMNETISHQRNDTMELHAPQNKCSEQMEGNNYISRNAQDELKLINKKKTDEHEKLCSQEVIEKRVKRDNQNKENIYGHNKNEDNIYGHNKNEDNIYGHNKNEDNIYGDIKNKENIYGDKKNKDNIYDEVSYTNNLSTTDKSYSTNIEDKKGNMKKRTFGEFIEKGKDTKKYISSDNNNNNNNNNSNDSNNNNSNNSSNNSDMLDVNIVNEIRIKKDLELLFNIGDKDLKYNEIQNIFIFLEMTTDYKPNLLQQSCLDCLFCFLNDFKNNVHEKMLVEKVTLTTIHKAKGLEWKVVFIINVTEGEIPQAVDSKQDIIEERKIFYVGITRAKFLLYLLCSIQNNNSEKNTVSRFINEMNI
Protein: Trailer hitch, isoform F (M9PI44)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGGLPELGSKISLISKADIRYEGRLYTVDPQECTIALSSVRSFGTEDRDTQFQIAPQSQIYDYILFRGSDIKDIRVVNNHTLPHHNDPAIMQAQLQNGPPQMPQHFPMPSGMSGPPQQQQVPSQQPPQMPSGGGSGGAGGAGAPGGGGPGYGNGNPFGNLGGPNLANMVGNAGGSLAPGSGAPGSGPFMHIGGNQQQPKPQQQKQPNMLAGASRSTTPISLIVSPTAELTQQQQLHQQQNAGQGGNGRDAGHKRQNHQQQQNQQHQQRGGPSHNNMQQQQQRGGGSGTDFYNQQRDRRDSGRQMDNNYSNNYNNNNNNQRNRGGGNGMQQQQRGGNGGSGGGGGNGGGNNPAWNMHRGNQNSNNMMNMRNRGMGSRGPMRPNQGYRPQSANNQNKPRNKIKFEGDFDFEQANNKFEELRSQLAKLKVAEDGAPKPATNATAATATATNEQVGEKVEGVHTLNGETDKKDDSGNETGAGEHEPEEDDVAVCYDKTKSFFDNISCEAAQDRSKNKKNDWRQERKLNTETFGVSSTRRGSSYRGRNQYYNNNGNGGINSGYGGAPGYNRNNYRMGGGGGNFRNRSNNRNNGGGRGGNGMPNITNGNTAAALKAANNAAGHGSNATDSSAPNATTATTKSTSLLPEQTQQVAAVSQ
Protein: Protein cornichon homolog 2 (CNIH-2) (Cornichon family AMPA receptor auxiliary protein 2) (Cornichon-like protein) (O35089)
Organism: Mus musculus (Mouse)
Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic density {ECO:0000269|PubMed:21172611}. Cell projection, dendrite {ECO:0000269|PubMed:21172611}. Cell projection, dendritic spine {ECO:0000269|PubMed:21172611}. Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.
Interaction partners:
- Glutamate receptor 1
- Voltage-dependent calcium channel gamma-8 subunit
- Glutamate receptor 2
- Protein shisa-9
- Glutamate receptor 3
- Disks large homolog 4
- Glutamate receptor 4
- Voltage-dependent calcium channel gamma-2 subunit
- Voltage-dependent calcium channel gamma-7 subunit
- Protein shisa-6
Sequence:
MAFTFAAFCYMLTLVLCASLIFFVIWHIIAFDELRTDFKNPIDQGNPARARERLKNIERICCLLRKLVVPEYSIHGLFCLMFLCAAEWVTLGLNIPLLFYHLWRYFHRPADGSEVMYDAVSIMNADILNYCQKESWCKLAFYLLSFFYYLYSMVYTLVSF
Protein: DNA-dependent metalloprotease dvc-1 (EC 3.4.24.-) (DNA damage protein targeting VCP) (DVC1) (Protein with SprT-like domain at the N terminus) (Spartan) (Q22557)
Organism: Caenorhabditis elegans
Function: DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Regulator of UV-induced DNA damage response: required to protect genome stability during DNA replication, possibly via recruitment of vcp/p97 (cdc-48.1 or cdc-48.2) recruitment.
Subcellular location: Nucleus {ECO:0000269|PubMed:23042605}. Chromosome {ECO:0000269|PubMed:23042605}. Note=Localizes to nuclear foci following UV treatment.
Interaction partners:
- BTB domain-containing protein
- G2/mitotic-specific cyclin-B
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
- Embryonic mRna
- glucosamine-phosphate N-acetyltransferase
- Uncharacterized protein
- Uncharacterized protein C05C10.5
- glutamine synthetase
- EF-hand domain-containing protein
- Chondroitin proteoglycan 4 domain-containing protein
Sequence:
MSRSSLVDPSFELSDPCPDIHALFIQFDARFFGGSLACCEVKWSPRMYACAGICSYEIRGGRGGLCSIRLSKPLLTLRPRSDLVETLLHEMIHAYLFVKERNRDRDGHGPQFQAHMHRINQAGGTNITIYHSFHDEVRLYKQHWWRCSGPCRDRRPFFGYVKRSCNRAPGPNDRWWSQHQQSCGGNFLKVKEPEGYGQGKGSKRTNDKNKSGGPALKKTITPPRVTLDDFFKKDGKNSSDNSTSKSPTKPSTSLFTGSGQKLGGSSSTSSLLNSYPKATQNSGGNRLGGTSGGVSRLLPPVNFTSPSSAPVAEQVIDLGDSDDDDFQDMDDDALEISFVASDNSVICPSCNTEVMENLIHGHLDYCLG
Protein: tRNA (guanine(10)-N(2))-methyltransferase TRMT11 (EC 2.1.1.214) (tRNA methyltransferase 11 homolog) (Q7Z4G4)
Organism: Homo sapiens (Human)
Function: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:34948388}.
Interaction partners:
- Multifunctional methyltransferase subunit TRM112-like protein
- tRNA
- 18S rRNA
- WD repeat-containing protein 36
- tRNA-dihydrouridine
- Methyltransferase HEMK2
- tRNA
- tRNA
- tRNA
- tRNA
Sequence:
MALSCTLNRYLLLMAQEHLEFRLPEIKSLLLLFGGQFASSQETYGKSPFWILSIPSEDIARNLMKRTVCAKSIFELWGHGQSPEELYSSLKNYPVEKMVPFLHSDSTYKIKIHTFNKTLTQEEKIKRIDALEFLPFEGKVNLKKPQHVFSVLEDYGLDPNCIPENPHNIYFGRWIADGQRELIESYSVKKRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVYGTDIDYNTVHGLGKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSDASKPSWRKGTYFDAIITDPPYGIRESTRRTGSQKEIPKGIEKWEKCPESHVPVSLSYHLSDMFLDLLNFAAETLVLGGRLVYWLPVYTPEYTEEMVPWHPCLELVSNCEQKLSSHTSRRLITMEKVKKFENRDQYSHLLSDHFLPYQGHNSFREKYFSGVTKRIAKEEKSTQE
Protein: Nonsense-mediated mRNA decay factor (E9PD50)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369098}.
Interaction partners:
Sequence:
MRNWMFLQIVIVGENVSFKSQMRTENLKSEEHLKSSNIRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPLQNESQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPHEEDLSSISATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQETSVIESLAADGSPGLKSVLSTSRNLSNNCDTGEKPVVTFKENIKTREVNRDQGRSFPPKEVKSQTELRKTPVSEARKTPVTQTPTQASNSQFIPIHHPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQPTAHSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGPQQSQPPSQQPLTSLPAQPTAQSTSQLQVQALTQQQQSPTKAVPALGKSPPHHSGFQQYQQADASKQLWNPPQVQGPLGKIMPVKQPYYLQTQDPIKLFEPSLQPPVMQQQPLEKKMKPFPMEPYNHNPSEVKVPEFYWDSSYSMADNRSVMAQQANIDRRGKRSPGVFRPEQDPVPRMPFEDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLFKSLLEKPSELMSHSSSFLSLTGFSLNQERYPNNSMFNEVYGKNLTSSSKAELSPSMAPQETSLYSLFEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHNHNSVPFSNFGPIGTPDNRDRRTADRWKTDKPAMGGFGIDYLSATSSSESSWHQASTPSGTWTGHGPSMEDSSAVLMESLKSIWSSSMMHPGPSALEQLLMQQKQKQQRGQGTMNPPH
Protein: ENTH domain-containing protein C19F8.03c (O60167)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Epsin-1
- Endocytosis protein end4
- ENTH domain-containing protein C794.11c
- Probable clathrin heavy chain
- Uncharacterized transporter C794.04c
Sequence:
MSPSKWLLTYERAVKKATKVKLAAPKYKHVEIILEATTEDPETLENVIQALCERLKEQSWTIVFKTLIVFHVMLKEGAPNTTIVALSQRPRILEVLKASSLLAQGKNIYNYSRFLSERAKQYGRLGVDYAQVGDAPKKKIREMKLENGLLRNVEGIQAQLRRLIKCQFVAEEIDNDIAITAFRLLVGDLLVLFKAVNIGVINVLEHYFEMGHHDAAQSLRIYKTFVNQTEDIINYLSTARSLEFVTKFPVPNIKHAPISLTASLEEYLNDPDFEENRKQYLQNKSGSPVEETAILNRKPTLRKKKSIPKKQNESSSTIQKENTVQQEASSSEEEAVKSLPETQRTTSRIETQEEEIKEEEMEGEEEEEEEEVPNYESENELEDKVGDLSLSLGVASSFVDEMLRERNNLSAEGTSASPSLDKKSESTNIVQPIPSHPNDSLNPFYNSSSPTYHPQPIPPQLQQVQLLSQMAGNQMANIQYTMNGMQQTGASPNTALNISQVNMYAQNNPVNPSTTNPFQNFLRQPSYQGMQFEQQQPTTIPLQPNIPVLNQQYPVMIPAMEDSRGPLPSPAHIMYPEGSPGFIQHSPNGFTHGHSASPVNIGQKLDVPERPMSTPYTASKNPFSTRELAEPTDLARNSISTESKNPFRS