wanglab/gogpt-training-data huggingface dataset:
Protein: Mitotic spindle checkpoint protein (Mad2), putative (AFU_orthologue AFUA_3G14340) (Q5BAB9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- 20S cyclosome subunit
- Spindle assembly checkpoint protein SLDB
- Anaphase-promoting complex subunit 4
- Uncharacterized protein
- Anaphase promoting complex subunit 10
- Spindle assembly checkpoint component MAD1
- Negative regulator of mitosis
- Protein bimA
- Cell division cycle protein Cdc20, putative
- 20S cyclosome subunit
Sequence:
MSTSKDKSKDKVHKLSIKGSSKLVAEFFEYSINSILFQRGVYPPEDFTTVKKYGLNMLVTADDQVKAYIKKIMSQLNKWMLGGKISKLVVVITDKETGEHVERWQFDVQIFGKQKSQSTRKSGDKENDTPGDVGQPETVEKTEKQIQEEIQAIFRQITASVTFLPVLDGDCTFNVLVYADADSDVPVEWGDSDAKDIKNPEKVQLRSFSTNNHRVETMVSYRLAD
Protein: U6-myrmicitoxin-Mri1a (U6-MYRTX-Mri1a) (A0A6G9KHD1)
Organism: Manica rubida (European giant red ant)
Subcellular location: Secreted {ECO:0000269|PubMed:32182430}.
Interaction partners:
Sequence:
MNPKALCSFLLATFLLLTVTIMPSVHANAEANADAIIGPCPKKPIGIVC
Protein: E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (Goliath homolog) (H-Goliath) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130) (Q86XS8)
Organism: Homo sapiens (Human)
Function: May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16549277}.
Interaction partners:
- Protein FAM131B
Sequence:
MSCAGRAGPARLAALALLTCSLWPARADNASQEYYTALINVTVQEPGRGAPLTFRIDRGRYGLDSPKAEVRGQVLAPLPLHGVADHLGCDPQTRFFVPPNIKQWIALLQRGNCTFKEKISRAAFHNAVAVVIYNNKSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSLVFVSISFIVLMIISSAWLIFYFIQKIRYTNARDRNQRRLGDAAKKAISKLTTRTVKKGDKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALGIVPNLPCTDNVAFDMERLTRTQAVNRRSALGDLAGDNSLGLEPLRTSGISPLPQDGELTPRTGEINIAVTKEWFIIASFGLLSALTLCYMIIRATASLNANEVEWF
Protein: NACHT, LRR and PYD domains-containing protein 9C (NALP-zeta) (Q66X01)
Organism: Mus musculus (Mouse)
Function: May be involved in inflammation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q66X22}.
Interaction partners:
- Baculoviral IAP repeat-containing protein 1f
- Baculoviral IAP repeat-containing protein 1b
- Baculoviral IAP repeat-containing protein 1e
- NLR family CARD domain-containing protein 4
- Pyrin
- Interferon-inducible protein AIM2
- NACHT, LRR and PYD domains-containing protein 9A
- Apoptosis-associated speck-like protein containing a CARD
- NACHT, LRR and PYD domains-containing protein 9B
- NACHT, LRR and PYD domains-containing protein 3
Sequence:
MVDSSSYGLLQYFQKLSDEEFQRFKELLQKEQEKFKLKPLSWTKIKNTSKEDLVTQLYTHYPRQVWDMVLNLFLQVNRKDLSTMAQIERRDKQNKYKEFMKNLFQYIWTSETNTYMPDRSYNTIIDRQYKALLDIFDSESDPATAVVLGTRGKGKTVFLRKAMLDWASGVLLQNRFQYVFFFSVFSLNNTTELSLAELISSKLPECSETLDDILSNPKRILFVLDGFDYLKFDLELRTNLCNDWRKRLPTQNVLSSLLQKIMLPECSLLLELGESSCSKIIPLLQNPREIIMSGLSEQSIYFYCVSFFKIQLGVEVFKDLKKNEPLFTLCSNPSMLWMICSSLMWGHYSREEVISSSESTSAIHTIFIMSAFKSIFGLGSSKYKRFKLKTLCTLAVEGMWKQVYVFDSEDLRRNKISESDKTVWLKMKFLQIQGNNIMFYHSTLQWYFATLFYFLKQDKDTYHPVIGSLPQLLGEIYAHKQNQWTHAQTFFFGIATKHVITLLKPCFGNISFKTIRQEIIRYLKSLSQPECNEKLVHPKKLFFCLIENQEERFVSQVMNLFEEITVDISDSDDLGAAEYSLLRASKLKNLHLHIQKKVFSEIHDPEYGSLENFKLDQKFSAINWTMLSILFCNLHVLDLGSCHFNKKVIEVLCNSLSPTPNMPLTVFKLQRLLCSFMTNFGDGSLFCTFLQIPQLKYLNLYGTDLSNDVVEMLCSALKCSTCRVEELLLGKCDISSEACGIMATFLINSKVKHLSLVENPLKNKGVMFLCKMLKDPSCVLESLMLSYCCLTFIACGHLYEALLSNKHLSLLDLGSNFLEDIGVNLLCEALKYPNCTLKELWLPGCYLTSECCEEISAVLTCNKNLKTLKLGNNNIQDTGVKRLCEALCHPKCKVQCLGLDMCELSNDCCEDLALALITCNTLKSLNLDWNALHHSGLVMLCEALNHKKCKLNMLGLDKSSFSEESQTFLQAVEKKNNNLNVLHFPWVEDELKKRGVRLVWNSKN
Protein: F-box protein 2 (A0A8I6A9Y7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
SRAPDFSLGPGSPWTQRPNPESVSHPEEASPEEQPEEAGAEASAEEEQPREEEEEETEAVEYLAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGSADDERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWCDVEHGGDGWRVEELPGDSGVEFTHDDSVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSEHEDVLAEFNTGQVAVPEDGSWMEISHTFTDYGPGVRYVRFEHGGQDSVYWKGWFGARVTNSSVWVEP
Protein: Neuropeptide receptor 22 (Q59E83)
Organism: Caenorhabditis elegans
Function: Receptor for the LURY-1-1 and LURY-1-2 peptides which control food-related processes including feeding, lifespan, egg-laying and roaming behavior. Receptor for flp-7 which stimulates serotonin-induced fat loss. Serotonin induces secretion of flp-7 from neurons and binding to npr-22 which leads to induction of the atgp-1 lipase and subsequent fat loss. Acts in vitro as a receptor for the flp-7 FMRFamide-like neuropeptides TPMQRSSMVRF-amide, SPMQRSSMVRF-amide, SPMERSAMVRF-amide and SPMDRSKMVRF-amide. Also acts in vitro as a receptor for a number of other FMRFamide-like neuropeptides including the flp-1 neuropeptide PNFMRY-amide, the flp-9 neuropeptide KPSFVRF-amide, the flp-11 neuropeptides AMRNALVRF-amide, ASGGMRNALVRF-amide and NGAPQPFVRF-amide, the flp-13 neuropeptides AADGAPLIRF-amide, ASPSAPLIRF-amide, SPSAVPLIRF-amide, SAAAPLIRF-amide and ASSAPLIRF-amide, and the flp-22 neuropeptide SPSAKWMRF-amide. The SPMERSAMVRF-amide neuropeptide from flp-7 acts as the strongest in vitro activator of npr-22.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- FMRFamide-like neuropeptides 7
- G-protein coupled receptors family 1 profile domain-containing protein
- FMRFamide-like neuropeptides 11
- FMRFamide-like neuropeptides 22
- Luqin-like RYamide peptides lury-1
- FMRFamide-like neuropeptide 18
- FMRFamide-like neuropeptides 9
Sequence:
MDEGGGIGSSLLSRITTTASEIMMRNEPTTTENPAVQEMNHIYHLTPSMKMLCILFYSILCVCCVYGNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFSYWQVLIYDDQRWLFGSMMCSLLAFLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRALYLVAATWIFSILMALPLLFTTRFFEDQDGLPNCGENWTYFGDSGEQVRKVYSSMVLILQYVVPQAVLIITYTHIGIKMWNSRVPGMQNGATKKMIVDRHESVKKLVPMVILISALFALCWLPLLILINVIPEFYPDINSWGYILYLWWFAHGLAMSHSMVNPIIYFIRNARFREGFCFFSSKLLPCISFKELRLLTDNTSRSFRNRSRFSGVINPTSSDEKPATSLTRYSRSGVLDRQTCRSARFFEARPLVVVRNNSANSLA
Protein: Twinkle mtDNA helicase (D3ZA68)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- DNA polymerase subunit gamma-1
- Single-stranded DNA-binding protein, mitochondrial
- DNA polymerase subunit gamma-2
- DNA-directed RNA polymerase
- Mitochondrial genome maintenance exonuclease 1
- Transcription factor A, mitochondrial
- Ribonuclease H1
- Deoxyguanosine kinase
Sequence:
MWLLLRRAYPLRILLPLRGEWMGRRGLPRSLAPGPPRRRYRKEALPALEVPVSPVTTTEIRQYLRAHGIPFQDGHSCLRAPSPFVAPSDIKNQKKDATTSFCLFIDKTTGHFLCMTSLAEGSWEDLQASVEGRGDGAKEGILLGEGPEAEDREEVLRIWNRAIPLWELPDPQETQLARVMFGLTKVTDDTLRRFNVRYLRSTRSLVFPWFTPGSSGLRGLKLLGVEGQENGVQYVETTIPRPGVYHNLFGLPLIGRRDTEVVLTSRELDSLALSQSTGLPTLSLPRGTVCLPPALLPYLEQFRRIVFWLGDDLRSWEAAKLFARKLNPKRCSLVRPGNQQPRPLEALNQGLSLPRILRTALPAWHKSIVSFRQLREEVLGELSNVDQAAGVRWSRFPDLNRLLKGHRKGELTVFTGSGKTTFISEYALDLCTQGVNTLWGSFEISNVRLARVMLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNLQFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLKKIKDDNGLVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSR
Protein: DNA-directed RNA polymerases I, II, and III subunit RPABC2 (DNA-directed RNA polymerase II subunit F) (RPB6 homolog) (U3KQB0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKYERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGVDELIITD
Protein: Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e) (Q8N6C8)
Organism: Homo sapiens (Human)
Function: Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MTPILTVLICLGLSLDPRTHVQAGPLPKPTLWAEPGSVITQGSPVTLRCQGSLETQEYHLYREKKTALWITRIPQELVKKGQFPILSITWEHAGRYCCIYGSHTAGLSESSDPLELVVTGAYSKPTLSALPSPVVTSGGNVTIQCDSQVAFDGFILCKEGEDEHPQCLNSHSHARGSSRAIFSVGPVSPSRRWSYRCYGYDSRAPYVWSLPSDLLGLLVPGVSKKPSLSVQPGPVVAPGEKLTFQCGSDAGYDRFVLYKEWGRDFLQRPGRQPQAGLSQANFTLGPVSRSYGGQYTCSGAYNLSSEWSAPSDPLDILITGQIRARPFLSVRPGPTVASGENVTLLCQSQGGMHTFLLTKEGAADSPLRLKSKRQSHKYQAEFPMSPVTSAHAGTYRCYGSLSSNPYLLTHPSDPLELVVSGAAETLSPPQNKSDSKAGE
Protein: Protein THEMIS (Thymocyte-expressed molecule involved in selection) (Q8N1K5)
Organism: Homo sapiens (Human)
Function: Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8BGW0}. Nucleus {ECO:0000250|UniProtKB:Q8BGW0}.
Interaction partners:
- Growth factor receptor-bound protein 2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- Linker for activation of T-cells family member 1
- Tyrosine-protein phosphatase non-receptor type 11
- Protein TESPA1
- COP9 signalosome complex subunit 1
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 7b
- COP9 signalosome complex subunit 5
Sequence:
MALSLEEFVHSLDLRTLPRVLEIQAGIYLEGSIYEMFGNECCFSTGEVIKITGLKVKKIIAEICEQIEGCESLQPFELPMNFPGLFKIVADKTPYLTMEEITRTIHIGPSRLGHPCFYHQKDIKLENLIIKQGEQIMLNSVEEIDGEIMVSCAVARNHQTHSFNLPLSQEGEFYECEDERIYTLKEIVEWKIPKNRTRTVNLTDFSNKWDSTNPFPKDFYGTLILKPVYEIQGVMKFRKDIIRILPSLDVEVKDITDSYDANWFLQLLSTEDLFEMTSKEFPIVTEVIEAPEGNHLPQSILQPGKTIVIHKKYQASRILASEIRSNFPKRHFLIPTSYKGKFKRRPREFPTAYDLEIAKSEKEPLHVVATKAFHSPHDKLSSVSVGDQFLVHQSETTEVLCEGIKKVVNVLACEKILKKSYEAALLPLYMEGGFVEVIHDKKQYPISELCKQFRLPFNVKVSVRDLSIEEDVLAATPGLQLEEDITDSYLLISDFANPTECWEIPVGRLNMTVQLVSNFSRDAEPFLVRTLVEEITEEQYYMMRRYESSASHPPPRPPKHPSVEETKLTLLTLAEERTVDLPKSPKRHHVDITKKLHPNQAGLDSKVLIGSQNDLVDEEKERSNRGATAIAETFKNEKHQK
Protein: Hydroxylysine kinase (EC 2.7.1.81) (A0A0C4DGM4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSSGNYQQSEALSKPTFSEEQASALVESVFGLKVSKVRPLPSYDDQNFHVYVSKTKDGPTEYVLKISNTKASKNPDLIEVQNHIIMFLKAAGFPTASVCHTKGDNTASLVSVDSGSEIKSYLVRLLTYLPGRPIAELPVSPQLLYEIGKLAAKLDKTLQRFHHPKLSSLHRENFIWNLKNVPLLEKYLYALGQNRNREIVEHVIHLFKEEVMTKLSHFRECEYSPN
Protein: Egg-laying defective protein 26 (Putative acyltransferase egl-26) (EC 2.3.1.-) (P91082)
Organism: Caenorhabditis elegans
Function: Putative acyltransferase (Probable). Plays a role in the morphogenesis of a vulval toroid cell, vulF, which is located where the vulva and the uterus connect. Not required for specifying vulval cell fate.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:11784109, ECO:0000269|PubMed:17560977}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLTCIQPSSSSIGGFGKADDNVRILLMASVRNEFGDTSIFSRLGVTALGQHYVLVTKKKMFGGYTTHMITANMRNRPFISIPFKVSSGAQSIEESRDLISRLTTVLGRPGMFSFDDPPIGSQFPVGKELIQLDEVPVGVHDRQDKYLEKGDEVFCEVNVSGVKFYHSGIYAGDGMCYHFVCDAQESESFADALAVFSGASAHVVYDTWFEFVYALVEVSDVPPKIFRASHPLICRSGEQVVKYAEHLQRELENYDIRRCNCQHFSSECSTGVPFSYDMTSNFKYLACTVLKPTSTVVNAMTRPNRDRSSFASSSTSS
Protein: LETM1 domain containing 1 (F8VZA2)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
Sequence:
MRLRTNATSSKLHLSPKADVKNLMSYVVTKTKAINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADAKKARRIKTNMWKHNIKFHQLPYREMEHLRQFRQDVTKCLFLGIISIPPFANYLVFLLMYLFPRQLLIRHFWTPKQQTDFLDIYHAFRKQSHPEIISYLEKVIPLISDAGLRWRLTDLCTKIQRGTHPAIHDILALRECFSNHPLGMNQLQALHVKALSRAMLLTSYLPPPLLRHRLKTHTTVIHQLDKALAKLGIGQLTAQEVKSACYLRGLNSTHIGEDRCR
Protein: Ventral anterior homeobox 2 (Q801E1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor that may function in dorsoventral specification of the forebrain. Required for closure of the choroid fissure and together with vax1 is required for optic nerve differentiation and to limit retinal development to the optic cup.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Paired box protein Pax-2a
- Six3
Sequence:
MFDQATSMGDGIAEDRNHCGSNSLCRDRGRESKSRTEVGNRSPVQSSTDTPGTSASTPTSSSEDGHDKLLGVDPDYCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLELEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQTKDTDKRSSSTSESLATCNILRLLEQGRLLSVPAPPPNPLLAHPHPGNGSLLGSPSVSTSSGVSSSTTPPGAGSGTFGLSLSSLSGTPPSPRLGVPPPSLCFTMPLLSGAHHELPSGYGCGTSAFEPYMRIERKDGELGGKKTVS
Protein: Uncharacterized protein, isoform B (A8DYA6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO01111p1
- Geranylgeranyl transferase type-2 subunit beta
- Cullin homolog 1
Sequence:
MFASSAETGVMEVGGTSGTGTGSSSSNNGGGSSSNSGGAGGSIELLCPPSGSSSISGSASFSSNSGASGSSSQTHSTAVSSATDRSNNNGNNHNPSLQLNGNGGSNTRQHSSGSNSRQHSSSSSNSNSSNISPPPSSSSSSRSNNNNNNHSSNIISGFCSTIWRSATFGSATPVINPLPAVSINPKIMESSSDSCSLSSSTTPDVGLADQQRNMAGSAQDQSEDQSQTFLGATELDDELIKQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLFDFQRDIEGPVIENISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKKITDISTQSISRYCSKLTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVEALARGCVKLRKFSSKGCKQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTLEVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIRHLTTGSCAAEILSVLELDNCPLITDRTLEHLVSCHNLQRIELFDCQLITRTAIRKLKNHLPNIKVHAYFAPGTPPAVTSGHRPRYCRCCEIL
Protein: Structural maintenance of chromosomes protein 5 (Q8IPT2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Non-structural maintenance of chromosomes element 4
- SD25546p
- MAGE
- Non-structural maintenance of chromosomes element 1 homolog
- E3 SUMO-protein ligase NSE2
- DEAD-box ATP-dependent DNA helicase Fancm
- DNA repair protein Rad60
- Condensin complex subunit 2
- Small ubiquitin-related modifier
- Nipped-B protein
Sequence:
MAGDRALSSKQLAGRIHSVYCKDFVSYSEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYIQSNKTSATIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANVHANREKEKSDLVKKQKRLEHLQMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKTRLLENAVAEKAAIDGKMDSLKQGIYQKKYELEQNIKKSRRTATECDNLNQLVENKIYELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQKLNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFVVTASRYRSDTILTESSIRAKNQLITVDSQQLALVMKQCSEAVKESDSIKNAITQTDNEFERLQAVAKDEQEKRRKLDQKIAHFNSLKTEIETLQKKLEALRNSDSLDCLETNFCNSLHKDLKKIFDADAELCSCLKAIDRLIIEKNMAQTKVSIYMLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFPFKKEFRELENIDLPELREAIHDFQARLECMKSVNSEAISSYQGLQNEVKQLEEGIQESVNQAKSIESGMSNLYDKWEPKLNSLVETISTKFSEFMESIEYVGEVVLSKTDKYDFDSYGIQIMVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVTPKLLRDLNYNEHLCVSIVHNSKTVCHGMQFPMA
Protein: Potassium binding protein Kbp (K(+) binding protein Kbp) (P0ADE6)
Organism: Escherichia coli (strain K12)
Function: Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+). May be involved in the regulation of peptidoglycan cross-linking.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:27112601}.
Interaction partners:
- UPF0339 protein YegP
- Osmotically-inducible protein Y
- Protein ElaB
- Uncharacterized lipoprotein YbaY
- Peroxiredoxin OsmC
- Uncharacterized protein YgaM
- NAD
- Trehalose-6-phosphate phosphatase
- Osmotically-inducible putative lipoprotein OsmE
- Uncharacterized protein YqjD
Sequence:
MGLFNFVKDAGEKLWDAVTGQHDKDDQAKKVQEHLNKTGIPDADKVNIQIADGKATVTGDGLSQEAKEKILVAVGNISGIASVDDQVKTATPATASQFYTVKSGDTLSAISKQVYGNANLYNKIFEANKPMLKSPDKIYPGQVLRIPEE
Protein: ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) (P47858)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
Interaction partners:
- Glucose-6-phosphate isomerase
- Fructose-bisphosphate aldolase A
- Fructose-bisphosphate aldolase B
- Fructose-bisphosphate aldolase C
- Transaldolase
- Fructose-1,6-bisphosphatase isozyme 2
- Fructose-1,6-bisphosphatase 1
- ATP-dependent 6-phosphofructokinase, platelet type
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
- Hexokinase-2
Sequence:
MTHEEHHEAKTLGIGKAIAVLTSGGDAQGMNATVRAVVRVGIFTGLRVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEERTKSSYLNIVFLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNTAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRPPVSKGGLHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKYNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGNPTPFDRNFATKMGAKATNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHISRKRSGEAAV
Protein: Rifin (Q8IIY3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHYINILLFALPLNILVRLCNVGSPHKNPSITPKFPPNTRLLCDCELYSPANYDSDPEMKAVMQGFDRQTSQRFEEYNERLLENKQKCKEQCDKEIQKIILKDKLEKELAEKFVTLQTDISINDIPTCVCEKSLGDKVEKSCLKCGKNLGGFIPGLGLIGGTAVYAAAVNAATKAGMKAALDELKSVNGLFQLLGENIKDLVTATNFNCKDALLRRIDTITTPLCKSDEAVNNLYCSLKSGKQPMGFSKIKSKISNAAEWAASASDEAKAEALNATFTWETFFSSPLGISLLVTVCIIIILSIIYLILRYRRKKKMKKKLQYIKLLEE
Protein: Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (Q5YLB2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR001734}. Chromosome {ECO:0000256|PIRNR:PIRNR001734}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex. {ECO:0000256|PIRNR:PIRNR001734}.
Interaction partners:
Sequence:
MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGIGTRFLCLPQSIYRSELNVYAFGEHILQISKYS
Protein: Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) (A0MS83)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in transcriptional regulation. Represses the transcription of a number of genes. Required for primitive and definitive hematopoiesis during embryonic development.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Protein kinase C
- ANKH inorganic pyrophosphate transport regulator a
- Tyrosine-protein phosphatase non-receptor type 9
- Tyrosine-protein phosphatase non-receptor type 9
Sequence:
MNIDDKLEGMLLKYSPVGLQHPSRGLGPSRVDGRGRRGSLDMTLGERSLANHPLLAEDDDDEDEEEDDDDDLAGEGLTSHDLISQDDLMVHEETVKNDGQDEAAFSHRISNKLHYTLSMPVNIKQEMKVPDSLILNKKEKKPGRDPSDCHKKKKRKQRSPAKILTINEDGSLGHQNPKSHICEHCNAAFRTNYHLQRHVFIHTGEKPFQCNQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMKFIQKYHMERHKRTHSGEKPYQCDYCHQFFSRTDRVLKHRRMCHENKDRKVQKTAVKDSPLRTPENLGFSFPAKDCTLPKKKRQKTSDKSRASITNPAVDKVVEADMDEKTEDRLAKSECLPLYAVATKVKDEYVVTDYSVELPDSPPGSRHLAGEESNDEIISPPKLVLKKIASRRGFKQQALEQSQSLSPLSSFEESKVTRYTFEIVDNKGLLDVETNPDMESVEALQVGQAKPTGSSTNYDDAMQFVKKRRYLQAATANTSRDYALNVSSIVSQSSVTQASVATVIDETVPATILSETQTLNVEIKSSNEKNVLPDEVLQTLLDHYSNKANGQAEISFSVADTEVTSSISINSSDESSPAEALVTSSQAPPTEKASLLQEYSKFLQQALERTSQNDTYLNNQSLTFVNDSASLAGQPLFSTEKQFTSPPRFRPTMNSPLRSTLEKPNFNLLVDTQHSFSFSGDETNPSSVSPTEDFLDQVTSPKKTDPQSISQTFQITTFDQNFRSQFPSSRSGISPQFSIASGQVTLRGHGGADFPEFSLVNETRTQLTSSPDATSSQTFG
Protein: Primosome protein PriB (Primosomal replication protein n) (P07013)
Organism: Escherichia coli (strain K12)
Function: Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT.
Interaction partners:
- Small ribosomal subunit protein bS6
- Small ribosomal subunit protein bS18
- Replication restart protein DnaT
- Replication restart protein PriC
- Large ribosomal subunit protein bL9
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL22
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
Sequence:
MTNRLVLSGTVCRAPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIVSGHENQAITHSITVGSRITVQGFISCHKAKNGLSKMVLHAEQIELIDSGD
Protein: Putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 (Q8VZT0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit 2-like protein
- H/ACA ribonucleoprotein complex subunit 3-like protein
- H/ACA ribonucleoprotein complex subunit 4
- Putative rRNA 2'-O-methyltransferase fibrillarin 3
- rRNA 2'-O-methyltransferase fibrillarin 1
- Telomerase reverse transcriptase
- rRNA 2'-O-methyltransferase fibrillarin 2
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein
- At4g22380
Sequence:
MRPPMRGGGGFRGRGGRDGGGGGRFGGGGGRFGGGGGRFGGGGGRFGGFRDEGPPSEVVEVATFVHACEGDAVTKLSQEKIPHFNAPIYLENKTQIGKVDEIFGPINESLFSIKMMEGIVATSYSPGDKFFIDPYKLLPLARFLPQPKGQSTGGRGGAGRGRGDSRGRGRGGSFSRGRGAPRGGRFPPRGGSRGSFRGRGRF
Protein: Annexin (G5EEA8)
Organism: Caenorhabditis elegans
Interaction partners:
- Actin
- Calreticulin
- SCP domain-containing protein
- SCP domain-containing protein
- Sperm vesicle fusion protein fer-1
- Tetraspanin
- Tetraspanin
- Tetraspanin
Sequence:
MTSPYATIVDAREFNAPMFAEKIDRALRAGEKDAVVNVITSISNAQRQQLREPYKLKYGKDIIQALDKKFSGDLEKAIFALMETPLDYDVKQLKAAMKGLGTDEAVLIEILCSRTVDQLRAIRVTYEKEYGKALEADIAGDTSGEFRDLLVSLVTGSKDGSHDTNDAQAKDDAVRLFADGKAKLAKKDGTHFLHILATQNQYQLRKVFAYFQELAGGSIEKSIEKEFSGDLQKSYLTIVRAASDKQKFFAQQLHASMKGLGTRDNDLIRVIVTRSEVDLELIKAEFQELYSKSLADTVKGDTSGAYRDALLSIINGNHATAH