wanglab/gogpt-training-data huggingface dataset:
Protein: Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) (Q7ZU92)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- m7GpppN-mRNA hydrolase
- polynucleotide adenylyltransferase
- Symplekin
- polynucleotide adenylyltransferase
- DIS3-like exonuclease 2
- Poly
- 5'-3' exoribonuclease 1
- Terminal nucleotidyltransferase 4A
- Death effector domain-containing protein
- Cytoplasmic polyadenylation element-binding protein 1
Sequence:
MEVTRQNFKEVLPEVCNAVQEADFISIDGEFTGISDGPSVSALTNGLDTPEERYTKLRKHSMNFLLFQFGVCTFRYDQNQSTYITKAFNFYIFPKPFSRTSPDIKFICQSSSIDFLASQGFDFNKVFRSGIPYLNQEEECQLREQYEERRGQMNGAGPVSYTPPSGTGVCNVPEDQREFIRSVEEKVEALLKNTDQTLDLEPCTGFQRKLIYQTLNSKYSKGLHVEALETEKKERFIQISKVDDEERRRREQQKQQREQEELNDAVGFSRVIRAISKSGKLVVGHNMLLDVMHTIHQFCGPLPEELDDFKEVAMTVFPRLLDTKLMASTQPFKEIIHNTSLAELHKQLRQKPFRPPTTECPEGLQSYDTSTEQLHEAGYDAFITGLCFISMANYLGSFLTPPKSHISARSKLLEPFYNKLFLMRVIDIPYLNMSGPDLQPKRDHVLYVTFPKEWKTSDLYQLFSAFGNIQVSWVDDTSAFVSLSQTEQVQIAMNTSRYAESYRIQTYAEYLQSRQKNTHSSRKWASDGWADTSYPSVAMTTASGYSHTDNWHQAVKRSISPSLDEQNHGADSSWTNYSVKKIKTEGSCTQTYADVAGSCDWPRLQADEGGASVSPVAEEAELDEFSANQSQGKRSRKHKKRKSDASETTPPALFDVPQVW
Protein: LK6 protein kinase (Q94548)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVEPKSGTAASAAAAKASNNNNNNHPRGSGDSGIRSGSGISCSNTDNSCSQSQSDGQNELTRYSSEDVSGNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGHLGILQLIEFFEDDKKFYLVFEKINGGPLLSRIQEHICFSEHEPSQIIKEIASGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSDENYNPKPPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRRSSRNASRNASAIYPNSGGFKTLNVHEEDDDDEGLEAFGHIDDDDEWSRSRREYQQQCETLGEDRFRRQSGSEGDEVEDDEDGENEDYQHYKHYWRELDEEEGDDYLYEQQQRVDDKFGEEEFEDEPKEETQADNLKLSKAYVEQVGETNVEKSKPQDDNGGYIREDLIMDNMDMKKNTQQSEFAKLTIMRNDAQTEENKIMQQQDEEKKEDKQQDDVDGAKKQGPSSDISATTITDNNKLQTPVMTTTHINNWQTGDAIEDDDVKLLDSISDLNEKLPEIYETANIVVNSAAVPAASTPAASATRPPTDNPEEDDSNVTKPTTTAEGTTMQTTFGMSAEEEKPVALSHTAGHHSKTGRTVNFAPDAYQNDEDADIDEDDDYDDEENLHEHSKQQLPSNAYTRKQRQQHQRYIVPRYQLADQVPQRQHTENWRYRTHHSQEQQPTADYRKYRPPFSTGGGGGHHGNLQRNYLGSFSHSGGAAGYKIAPMPPPMQPPPRHNSAGSSGSGSGSGGSPPSDEQSAIRNWRQDCVYARSCGMNQGPEQQRHNRSSGQRVQQQPRIGSGRFAHLQAAQLMDELPDMRIGLSPPSESVLLQRRLRQQQRANDLSEVLRAGHRQWLRGSTVDR
Protein: DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4) (P28858)
Organism: Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Function: Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).
Subcellular location: Host nucleus {ECO:0000250}. Note=The protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs. {ECO:0000250}.
Interaction partners:
Sequence:
MAAREQANSVRRSGFFNPFIGKRPFFRPGSGQTAETERPRPPQHSYCTEVGSFKFIAPRCLDEEAPADQRRGVHVGTLERPPKVYCDGSEYDVLNFASGGCWPRRIRVWNGQDFRGDGFNPRFERFHVYDIVETSESASHDDPSRFAELSRPSGSVVTLLGMSECGKRVAVHVYGVRHYFYMAKAEVDSACGITTEAELVRAMVDCAHSSALSAALGNGNGGKQSGGSGGGWWGGKHVSADCFKVETVCHTTLYYFGSKPALYYRVSASSSRLGGFICDNFHPEITKFEGSVDVTTRLLLDNENFTSFGWYRLRPGTHGERVQLRPVERHVTSSDVEINCTPDNLEPIPDEAAWPDYKLMCFDIECKAGTGNEMAFPVATNQEDLVIQISCLLYSLATQNHEHTLLFSLGSCDISEEYSFACVQRGEPRPTVLEFDSEYELLVAFLTFLKQYSPEFATGYNIVNFDWAYIVNKVTSVYNIKLDGYGKFNKGGLFKVWDIATNHFQKKSKVKINGLISLDMYSVATEKLKLPSYKLDAVVGDVLGEHKIDLPYKEIPSYYAGGPDRRGVIGEYCIQDSRLVGKLFFKYLPHLELSAVAKLARITLTRVIFDGQQIRVYTCLLKLARERNFILPDNRRRFDSQADAASETSELAMDSQSHAFDSTDEPDGVDGTPDAAGSGATSENGGGKPGVGRAVGYQGAKVLDPVSGFHVDPVVVFDFASLYPSIIQAHNLCFTTLALDEVDLAGLQPSVDYSTFEVGDQKLFFVHAHIRESLLGILLRDWLAMRKAVRARIPTSTPEEAVLLDKQQSAIKVICNSVYGFTGVANGLLPCLRIAATVTTIGRDMLLKTRDYVHSRWATRELLEDNFPGAIGFRNHKPYSVRVIYGDTDSVFIKFVGLTYEGVSELGDAMSRQISADLFRAPIKLECEKTFQRLLLITKKKYIGVINGGKMLMKGVDLVRKNNCSFINLYARHLVDLLLYDEDVATAAAEVTDVPPAEWVGRPLPSGFDKFGRVLVEAYNRITAPNLDVREFVMTAELSRSPESYTNKRLPHLTVYFKLAMRNEELPSVKERIPYVIVAQTEAAEREAGVVNSMRGTAQNPVVTKTARPQPKRKLLVSDLAEDPTYVSENDVPLNTDYYFSHLLGTISVTFKALFGNDVRTTENLLKRFIPETPHKTPTKTQALLERAGFEKLTPFTPEEESRRILHTVFCTLEAAPHQS
Protein: Lipoprotein-releasing ABC transporter permease subunit (Q9HZL6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Lipoprotein-releasing system ATP-binding protein LolD
- Lipoprotein-releasing ABC transporter permease subunit
- Outer-membrane lipoprotein carrier protein
- Pyoverdine export ATP-binding/permease protein PvdT
- Probable ATP-binding component of ABC transporter
- Outer membrane protein assembly factor BamA
- Probable glycine betaine-binding protein
- ABC-type glycine betaine transport system substrate-binding domain-containing protein
- Tol-Pal system protein TolQ
- Probable ATP-binding component of ABC transporter
Sequence:
MFRPLSVFIGTRYTRAKRRSHFVSFISLTSMIGLALGVLVMIVVLSVMNGFDREMRTRILGMVPQATVESYQPIDDWRALAEKVKAHEHVTAVAPFTQMQGMLSANGAVQTVMVDAVDPLEEAKVSIIPDFFKQGSLAELKAGGFGIVIGQLAAQKLGVGIGDKVTLILPEVAVTPAGVFPRMKRFTVVGTFRVGAGELDGGLSLIHLEDAARLQRWKTNQVQGLRLKLDDLFQAPRVAWEIARTLTDNDFYARDWTRSHGNLYQAIRMEKTMIGLLLLLIVAVAAFNIISTLVMVVTDKKSDIAILRTLGATPGQIMATFMVQGTVIGVIGTLVGGVLGVVAALNVSAWISALEKLLGHQFLASDVYFIDYLPSQLMLDDVVLVCGAALVLSFFATLYPAWRAARTQPAEALRYE
Protein: Carboxysome shell protein CcmK4 (Carbon dioxide-concentrating mechanism protein CcmK4) (Q31RK2)
Organism: Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2)
Function: One of the shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome. The hexamer central pore probably regulates metabolite flux.
Subcellular location: Carboxysome {ECO:0000255|HAMAP-Rule:MF_00854, ECO:0000269|PubMed:25117559, ECO:0000269|PubMed:28616951, ECO:0000269|PubMed:28963440, ECO:0000269|PubMed:31048338}. Note=This cyanobacterium makes beta-type carboxysomes (PubMed:25117559). Part of the carboxysome shell, not found in the interior (PubMed:28963440). {ECO:0000269|PubMed:25117559, ECO:0000269|PubMed:28963440}.
Interaction partners:
- Carboxysome shell vertex protein CcmL
- Carboxysome shell protein CcmP
Sequence:
MSQQAIGSLETKGFPPILAAADAMVKAGRITIVSYMRAGSARFAVNIRGDVSEVKTAMDAGIEAAKNTPGGTLETWVIIPRPHENVEAVFPIGFGPEVEQYRLSAEGTGSGRR
Protein: Heatshock protein cognate 70Cb (Q9XZT5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSVIGIDFGNESCYVAAARSGEIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNVIFVDFGHSSLQASACAFTKGKLKMLASTWDQIGGRDIDLALGDYFAKEFQERYKINAKTNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVREFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPYPDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEEKPGDQTNNTGEPADGQQEGADKKKKASKATELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKDEANAEQNGGEPAANSGDKMDVDNNGQSAAGNDPSMEVE
Protein: Glutamate receptor 3.6 (Ligand-gated ion channel 3.6) (Q84W41)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glutamate-gated receptor that probably acts as non-selective cation channel. Mediates leaf-to-leaf wound signaling. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 14
- Two pore calcium channel protein 1
Sequence:
MKWFLLMLIICNAVPLQGLTKIVSARPQVVNIGSVFTFNSLIGKVIKVAMDAAVEDVNASPSILNTTTLRIIMHDTKYNGFMSIMEPLQFMESETVAIIGPQRSTTARVVAHVATELKIPILSFSATDPTMSPLQFPFFIRTSQNDLFQMAAIADIVQFYGWREVVAIYGDDDYGRNGVAALGDRLSEKRCRISYKAALPPAPTRENITDLLIKVALSESRIIVVHASFIWGLELFNVARNLGMMSTGYVWIATNWLSTIIDTDSPLPLDTINNIQGVITLRLHTPNSIMKQNFVQRWHNLTHVGLSTYALYAYDTVWLLAQAIDDFFKKGGNVSFSKNPIISELGGGNLHLDALKVFDGGKIFLESILQVDRIGLTGRMKFTSDRNLVNPAFDVLNVIGTGYTTIGYWFNHSGLSVMPADEMENTSFSGQKLHSVVWPGHSIKIPRGWVFSNNGRHLRIGVPNRYRFEEVVSVKSNGMITGFCVDVFIAAINLLPYAVPFELVAFGNGHDNPSNSELVRLITTGVYDAGVGDITIITERTKMADFTQPYVESGLVVVAPVRKLGSSAMAFLRPFTPQMWLIAAASFLIVGAVIWCLEHKHNDEFRGPPRRQVITTFWFSFSTLFFSHRETTTSNLGRIVLIIWLFVVLIINSSYTASLTSILTVHQLSSPIKGIETLQTNHDPIGYPQGSFVRDYLIHELNIHVSRLVPLRSPEEYDKALRDGPGKGGVAAVVDERAYIELFLSNRCEFGIVGQEFTKNGWGFAFPRNSPLAVDVSAAILQLSENGDMQRIRDKWLLRKACSLQGAEIEVDRLELKSFWGLFVVCGVACVLALAVYTVLMIRQFGQQCPEEAEGSIRRRSSPSARIHSFLSFVKEKEEDAKARSSRERQLEDISANGSSRCN
Protein: pH-response regulator protein palA/RIM20 (Q9UW12)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease RIM13 via SNF7 to its substrate RIM101 (By similarity). Required for filamentation.
Interaction partners:
- Vacuolar-sorting protein SNF7
- pH-response transcription factor pacC/RIM101
- Calpain-like protease palB/RIM13
- pH-response regulator protein palF/RIM8
- pH-response regulator protein palH/RIM21
- pH-response regulator protein palI/RIM9
- Ubiquitin-binding ESCRT-I subunit protein
- ESCRT-III subunit protein
- Mg-dependent acid phosphatase
- Vacuolar protein-sorting protein BRO1
Sequence:
MNTNLLFIPLKQSSVLDLGDELRQVITNNYFQPASSFNSDLIYITQLRNQVAQIKNVNDELGKTSQDDSILLEYLQVLNTLQNKFSDDCVEFAWFDTLAYGPQGPYRYRSLKIEKLNVIYQIGSLYSQIAISESRHTDIGLKRACHYFQLSAGCFMFINNFLIETIKNKNDPLVLSIPLSMQSSTIQCLEYLMLAQAQETIWQKAINNNSMKDSVVARLSIQTSEYYSKALDFGNSSDLIKLEWINHMKVKKLHFLAAAHLRSSTIAADSFQYGEQVAHLRVASQAVDQALKSKKYVNSLVLEDLQGLADVIKVRLRTAEKDNDLVYLKIVPQEKELKTIIGVSMVKSIIPEAFEQKPESNTEIFKELLPYVIIHVAQAMRERQDEYVQTKFHTPISSLNNMLVKFLIDRDLPSSIDSIQQPENIPDSVIHHSQEILKTGGVDFIDKAFKELDKLKLECNHLLQECETRIDLDRSEDDMLRRKQGSTRWTRKSTDDAAQELIKKVDKMKQYLLQANNGDGFVLKKFYDIKPALDVYSSGYKALSQYIPNSQYIELPEQLSIVISDLRSCLARANTLESERKEFLQTLEIRSRDNSILPKLITEYNSNRSKYQTENGEFNFNAFESVYEKHMKLFDSDIKYIARTRDSQMTLEHEIDSINQKFVQEFKSLQNSSNEKRQQVLQYLETAYEKFLEIINNLTEGSKFYTDFIEKGSAVLQECEEYLYRRRVESRDLELAISNSFQQQQQVQEQNEQLSVPRNYSNDKLISPKTSKPGLWNPNSDIQFS
Protein: Lysine/arginine/ornithine-binding periplasmic protein (LAO-binding protein) (P09551)
Organism: Escherichia coli (strain K12)
Function: Part of an ABC transporter involved in lysine, arginine and ornithine transport. Stimulates ATPase activity of HisP (By similarity).
Subcellular location: Periplasm {ECO:0000250|UniProtKB:P02911}.
Interaction partners:
- Histidine/lysine/arginine/ornithine transport system permease protein HisM
- Histidine/lysine/arginine/ornithine transport system permease protein HisQ
- Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP
- Arginine ABC transporter permease protein ArtQ
- Glutamine transport system permease protein GlnP
- Glutamate/aspartate import permease protein GltK
- L-cystine transport system permease protein TcyL
- Arginine ABC transporter permease protein ArtM
- Inner membrane amino-acid ABC transporter permease protein YhdY
- Glutamate/aspartate import permease protein GltJ
Sequence:
MKKSILALSLLVGLSTAASSYAALPETVRIGTDTTYAPFSSKDAKGDFVGFDIDLGNEMCKRMQVKCTWVASDFDALIPSLKAKKIDAIISSLSITDKRQQEIAFSDKLYAADSRLIAAKGSPIQPTLDSLKGKHVGVLQGSTQEAYANETWRSKGVDVVAYANQDLVYSDLAAGRLDAALQDEVAASEGFLKQPAGKDFAFAGSSVKDKKYFGDGTGVGLRKDDAELTAAFNKALGELRQDGTYDKMAKKYFDFNVYGD
Protein: Probable serine hydrolase (EC 3.1.-.-) (Kraken protein) (O18391)
Organism: Drosophila melanogaster (Fruit fly)
Function: May have a role in detoxification and digestion during embryogenesis and larval development.
Interaction partners:
Sequence:
MGQTRVAATTAAQSPAAELSPETNGQTEEPLQLLGEDSWEEFSIAVPWGTVEAKWWGSKERQPIIALHGWQDNCGSFDRLCPLLPADTSILAIDLPGHGKSSHYPMGMQYFIFWDGICLIRRIVRKYNWKNVTLLGHSLGGALTFMYAASFPTEVEKLINIDIAGPTVRGTQRMAEGTGRALDKFLDYETLPESKQPCYSYDEMIKLVLDAYDGSVDEPSVRVLMNRGMRHNPSKNGYLFARDLRLKVSLLGMFTAEQTLAYARQIRCRVLNIRGIPGMKFETPQVYADVIATLRENAAKVVYVEVPGTHHLHLVTPDRVAPHIIRFLKEA
Protein: Uncharacterized protein YmgC (P75994)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Probable two-component-system connector protein AriR
- Probable two-component-system connector protein YmgA
- Probable two-component-system connector protein YcgZ
Sequence:
MNNSIPERFIFQCALFKNLEREVFMTHGYVDSHIIDQALRLRLKDETSVILSDLYLQILQYIEMHKTTLTDIIINDRESVLS
Protein: Protein encore (Q8MSX1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the regulation of germline mitosis, karyosome formation, and establishment of dorsoventral (DS) polarity of the egg and embryo. Involved in proper grk mRNA localization and translation in the oocyte. May control germline mitosis by facilitating the cyclin E (CycE) proteolysis by the SCF-ubiquitin-proteasome complex.
Subcellular location: Cytoplasm. Note=Colocalizes with grk.
Interaction partners:
- Mitochondrial glutamate carrier 2
Sequence:
MSSTKSQVALATNIPTNLSSAASASTAAAAAAVVVVASANAAVASSANSSGVGSGSGPGPGSGAGVSGPVAAGTATAVATGSTVTAATSVAATTSTSVATISTSCSSSSINNINNNCGEECQSAAGSSNLGRQNSFGNRRGNMKGKHLTRSHAMRESTSPPRTPTPRAASEQQQQQLQGEQHEHNNNNNINSSSKAQSAGRGNSPLMETPAVIVTSQQPQQQQQQQQQQQQSVPPKPQQNVPLSNEAEFPKLSPPKKSGGQHNRTNSNGSGMEFNNNNNSSNKKFVVDMKANGLDNKPHNNSSTGVIFNSGMNYKAAERHDRHERHEMSSQNSNLSNNHDEEPYHYEPRGGGGGKKHRANTNAKGNKPRLKNLGGSSSGSIDLGGGGGNGNCNNMSNNGQSNNSSNNTSGFISRENSSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRMLIHRTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDDARKSILKRDTHSFDEVRQSPYLCPLSLDRKAKSFEEREEDYDRARSRIFSRTGGNHDGYSGGGGDEECYGGWEQQQQQQKQSQPPRPKRPNGKMLQMQNSTESRDGMRSGGAVPKSHNFGNYGGPPSSGGPGNNSLPRGDSTNSIKSGRGGFVKQDSTGSTPWRLSPSSSGSIYHYDPSNLPPNQALQHSGNQYQSQNQGNSSSGGYNNYRKSSPHQQQQSQQQQQSQQHHQQQLQQPQQLHQQSSQQYATTELSCSSTESYAEEEAQSPGMECSEGYESYEQQSLPVQQQLSGNGDSASTKGDDCDSLASATACLSITTSTSTKNYDRIEVQKYKNQATSPNIPACCAVGEKLELEAGLPQEQEQEPMAGPSSSGSATSSVGITELPSSQTPLPMVNQVNCDLQSVSPSTTPYSQCEVKTPSQNHAPSAAVEEPKTTTWTYTQSYQAPDGSTVFHTTTTPNGAAPYCATTYQQGPDGSIYAVPQGMVYAAYPQPGVGTAGGASQPLFQLTTSSHPPAQTIFASPEAGAEIPGGTYMIPVFDPAQQPREGLIPAQAIYQTGPGGPGATTVMPMATAAAYPTAQFATAAPNGAPIYQAPLIYSSEPGGGAQLQQLPMAPYPIQYSYPYYHPISYYVPQQAVAAAPMVASQPQVGQAPMQQQAPHTGAGTTTGPPTVVSVSGQQHHQPHQQHHQQQQHSSNGSVVTSSAYGTRVKRTPGGGSIHYNPSYTPSSVAHAGGAHHPSAGSAQIIAAPAASTTTYHALPTLTLAHGGPATGTDLSGAGGAHVYALPAQHALIPTNIFPYAAAAAAAAGGPGGPPTTPQVVQQAPPPPPQSAPHHALITAAPFYPANGGNMDQGASQSAPSTPAAPGRQAPLFSTPPAPNNGSSGSSSAGGGGNSGGYHSNSSTPHYYQGQNSNEGYTSPYEKRNHGGGASGAHSVGVRKPYHPGGYNPRHSVPLGGIPSGAKTPLLNSNNEPTPRASPSSVSLGGASSSGGANSYPHRGPPPHTMGVKRDNKPNQLPLISGPPPSYAANSSPGVSSYESKPPVRLNAGAASFRSQKSMNQDYRRSVSQRNSPSANGGGSGSHESSNNSPNSIVGSQSNSAANTPNAAAPPPPQPQPTLVSHSGGFVVLDQTTGAAMNASPPSLYGGGGGPNAGISGGAGASGAAGSNGGHQPGGGGGARSHIPTAQLHHSAAAAAAAAAGSQQATAAVLSGVAAAAALGGYNPNGASGVYFKYGQTYFAHPSVALPNSRRSPSNDIRPQMAQVAGMYPTMMIQARHPSRHPNPNYKGSRPR
Protein: Probable two-component-system connector protein YcgZ (P75991)
Organism: Escherichia coli (strain K12)
Function: Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two-component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component.
Interaction partners:
- Probable two-component-system connector protein YmgA
- Probable two-component-system connector protein AriR
- Uncharacterized protein YmgC
- HTH-type transcriptional repressor BluR
- Blue light- and temperature-regulated antirepressor BluF
Sequence:
MHQNSVTLDSAGAITRYFAKANLHTQQETLGEIVTEILKDGRNLSRKSLCAKLLCRLEHATGEEEQKHYNALIGLLFE
Protein: 2-methylisocitrate lyase (2-MIC) (MICL) (EC 4.1.3.30) ((2R,3S)-2-methylisocitrate lyase) (Q56062)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
Interaction partners:
- 2-methylcitrate synthase
- 2-methylcitrate dehydratase
- Propionate--CoA ligase
- Aconitate hydratase B
- Major outer membrane lipoprotein Lpp 1
- Malate synthase
- Succinate--CoA ligase subunit beta
- Succinate--CoA ligase subunit alpha
- Acetyl-coenzyme A synthetase
- PF03932 family protein CutC
Sequence:
MSLHSPGQAFRAALAKENPLQIVGAINANHALLAQRAGYQAIYLSGGGVAAGSLGLPDLGISTLDDVLTDIRRITDVCPLPLLVDADIGFGSSAFNVARTVKSIAKAGAAALHIEDQVGAKRCGHRPNKAIVSKEEMVDRIRAAVDARTDPNFVIMARTDALAVEGLEAALDRAQAYVDAGADMLFPEAITELSMYRRFADVAQVPILANITEFGATPLFTTDELRSAHVAMALYPLSAFRAMNRAAEKVYTVLRQEGTQKNVIDIMQTRNELYESINYYQFEEKLDALYRNKKS
Protein: Protein ESC8 (Establishes silent chromatin protein 8) (Q08119)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in HMR and telomere silencing via the recruitment or stabilizing of the SIR (silent information regulators) complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- ISWI chromatin-remodeling complex ATPase ISW1
Sequence:
MTEIIDLDLVDDFIKKPMVKQQKNQSSKPRVKRRGQLTFDDFRNIKIVEEPVVLSHNSSIDESLDAATQNTKKREKYEGTCDEEMKTKEMEANMASKYSNIKTHSNDTNKVESISEHTTSNNRPLNTLNWSPNIPLRYSDFAKFMSDETVTESNWAPPLCTPLPYAGDVMKILSFIVKFKWVFSDDLLNLSFQDVEIGLELKVAGHSAKNIRICQDKMNLLFCSLLRLLFCSEKRADNQTHRNFTLKRFLSLKNPYGKLVGKLRSLIQEWGLPKEWRGNSDILSTLNFNGGGLLTMEPLDRIILLRCMIDWNCSYSALFHNEIQRLTHLKGDTGFNHQTFHASRFAMCGANNILDSCEVLCSLMSQKLENRKKRKPSDKGKLSKINSQMKFLKGVRKSLSEKVTTDRLRAAVKINEEWGEYFANEFTHTPIDDPTVDEIYKLRTSEFMIARIPRVGDFYLPPFWIGNECSSVNTSYSFNDMSTYLNYFVKFKEEGTKILPAKTAQNENKCQLKLIYRNTPACIRNLQFNDVHFAEVPHWFEVAGDSNSLSNFIEYLESLSSLTENDTDDTKKGIDNLIEFLKIFSIFINETIQRITAAPTGSTEGRHLRTSSQRRTTVHYSSDVNGDVSEESENEVDIDVSDDYDSEYLSEENTLTRKGEDRTDKSFGKRELHNGAKDCDRNCDDIEIFSEPVRQLQDNSREKRSLRRNARKGL
Protein: Tachykinin-related peptide 5 (TKRP-5) (P86579)
Organism: Nezara viridula (Southern green stink bug) (Cimex viridulus)
Subcellular location: Secreted {ECO:0000269|PubMed:19084564, ECO:0000305}.
Interaction partners:
Sequence:
APLMGFQGVR
Protein: Peroxisomal ABC transporter 1 (F4JJ27)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MPSLQLLQLTERGRGLVASRRKSILLAAGIVAAGGTAVYLKSRVASRRPDSSRLCNGQSDDDETLEKLTATDQNAKITTKKKKGGGLKSLQVLTAILLSQMGKMGARDLLALVATVVFRTALSNRLAKVQGFLFRAAFLRRAPLFLRLISENIMLCFMLSTLHSTSKYITGALSLRFRKILTKIIHSHYFENMVYYKISHVDGRITHPEQRIASDVPRFSSELSDLILDDLTAVTDGILYAWRLCSYASPKYIFWILAYVLGAGTAIRNFSPSFGKLMSKEQQLEGEYRQLHSRLRTHSESIAFYGGETREESHIQQKFKNLVSHMSHVLHDHWWFGMIQDFLLKYLGATVAVILIIEPFFSGHLRPDDSTLGRAEMLSNIRYHTSVIISLFQALGTLSISSRRLNRLSGYADRIHELMAVSRELSGDDKSSFQRNRSRNYLSEANYVEFSDVKVVTPTGNVLVEDLTLRVEQGSNLLITGPNGSGKSSLFRVLGGLWPLVSGHIVKPGVGSDLNKEIFYVPQRPYMAVGTLRDQLIYPLTSGQESELLTEIGMVELLKNVDLEYLLDRYQPEKEVNWGDELSLGEQQRLGMARLFYHKPKFAILDECTSAVTTDMEERFAAKVRAMGTSCITISHRPALVAFHDVVLSLDGEGGWSVHYKRDDSALLTDAEIDSVKSSDTDRQNDAMVVQRAFAAARKESATNSKAQSYQTQLIARSPVVDKSVVLPRFPQPQTSQRALPSRVAAMLNVLIPTIFDKQGAQLLAVACLVVSRTLISDRIASLNGTTVKYVLEQDKAAFVRLIGLSVLQSGASSIIAPSLRHLTQRLALGWRIRLTQHLLRNYLRNNAFYKVFHMSGNSIDADQRLTRDLEKLTADLSGLLTGMVKPSVDILWFTWRMKLLTGQRGVAILYTYMLLGLGFLRRVAPDFGDLAGEEQQLEGKFRFMHERLNTHAESIAFFGGGAREKAVSFLIALAIAAGFWVMVDKKFRALLDHSLMLLRKKWLYGILDDFVTKQLPNNVTWGLSLLYALEHKGDRALVSTQGELAHALRYLASVVSQSFMAFGDILELHKKFLELSGGINRIFELDEFLDASQSGVTSENQTSRLDSQDLLSFSEVDIITPAQKLMASKLSCEIVSGKSLLVTGPNGSGKTSVFRVLRDIWPTVCGRLTKPSLDIKELGSGNGMFFVPQRPYTCLGTLRDQIIYPLSKEEAEKRAAKLYTSGESSTEAGSILDSHLKTILENVRLVYLLERDVGGWDATTNWEDILSLGEQQRLGMARLFFHRPKFGVLDECTNATSVDVEEQLYRVARDMGVTFITSSQRPALIPFHSLELRLIDGEGNWELRSIEQTTE
Protein: Septin-12 (Q8IYM1)
Organism: Homo sapiens (Human)
Function: Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. May play a role in cytokinesis (Potential).
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18047794}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18047794}. Nucleus {ECO:0000269|PubMed:25775403}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:22275165}. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus. Colocalized with SPAG4 at the nuclear periphery in round spermatids, at sperm neck in elongated spermatids and at midpiece regions in ejaculated spermatozoa. {ECO:0000269|PubMed:18047794, ECO:0000269|PubMed:20801438, ECO:0000269|PubMed:22275165, ECO:0000269|PubMed:25775403}.
Interaction partners:
- Uncharacterized protein C17orf47
- Septin-7
- Septin-2
- Septin-6
- Septin-5
- Septin-11
- Septin-1
- Neuronal-specific septin-3
- Septin-9
- Septin-10
Sequence:
MDPLRRSPSPCLSSQPSSPSTPPCEMLGPVGIEAVLDQLKIKAMKMGFEFNIMVVGQSGLGKSTMVNTLFKSKVWKSNPPGLGVPTPQTLQLHSLTHVIEEKGVKLKLTVTDTPGFGDQINNDNCWDPILGYINEQYEQYLQEEILITRQRHIPDTRVHCCVYFVPPTGHCLRPLDIEFLQRLCRTVNVVPVIARADSLTMEEREAFRRRIQQNLRTHCIDVYPQMCFDEDINDKILNSKLRDRIPFAVVGADQEHLVNGRCVLGRKTKWGIIEVENMAHCEFPLLRDLLIRSHLQDLKDITHNIHYENYRVIRLNESHLLPRGPGWVNLAPASPGQLTTPRTFKVCRGAHDDSDDEF
Protein: CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) (Phosphatidylserine synthase) (F4HXY6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368094}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368094}.
Interaction partners:
Sequence:
MEPNGYRKERRKEQHLGRMNGGGGDVETDLDPWTAWAYKPRTISLLLIGACFLIWASGALDPDSTTSDDLVTSVKRGVWAMIAVFLAYSLLQAPSTVLIRPHPAIWRLVHGMAVIYLVALTFLLFQRRDDARQFMKFLHPDLGIELPEKSYGADCRIYVPDHPTNRFKNLYDTVFDEFFLAHIFGWWGKAILIRNQPLLWVLSIGFELLEVTFRHMLPNFNECWWDSIVLDILICNWFGIWAGMYTVRYFDGKTYEWVGISRQPNIIGKVKRTLGQFTPAHWDKDEWHPLQGPWRFIQVLTLCIIFLTVELNTFFLKFSLWIPPRNPVILYRLILWWLIAIPTTREYNSYLQDRKPVKKVGAFCWLSLGICIVELLICIKFGSGRIVPNRNAIVGSDTMGKCGTWTCGLLAVLDMEDPEDPRAKETLSASLLLQQRRERNRGETVKCHCGFFL