wanglab/gogpt-training-data huggingface dataset:
Protein: HCG38478, isoform CRA_a (TATA-box binding protein associated factor 4b) (J3KTH2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSPVGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGTVLIKSNSGPLMLVSPQQTVTRAETTSNITSRPAVPANPQTVKICTVPNSSSQLIKKVAVTPVKKLAQIGTTVVTTVPKPSSVQSVAVPTSVVTVTPGKPLNTVTTLKPSSLGASSTPSNEPNLKAENSAAVQINLSPTMLENVKKCKNFLAMLIKLACSGSQSPEMGQNVKKLVEQLLDAKIEAEEFTRKLYVELKSSPQPHLVPFLKKSVVALRQLLPNSQSFIQQCVQQTSSDMVIATCTTTVTTSPVVTTTVSSSQSEKSIIVSGATAPRTVSVQTLNPLAGPVGAKAGVVTLHSVGPTAATGGTTAGTGLLQTSKPLVTSVANTVTTVSLQPEKPVVSGTAVTLSLPAVTFGETSGAAICLPSVKPVVSSAGTTSDKPVIGTPVQIKLAQPGPVLSQPAGIPQAVQVKQLFSLFQVVQQPSGGNEKQVTTISHSSTLTIQKCGQKTMPVNTIIPTSQFPPASILKQITLPGNKILSLQASPTQKNRIKENVTSCFRDEDDINDVTSMAGVNLNEENACILATNSELVGTLIQSCKDEPFLFIGALQKRILDIGKKHDITELNSDAVNLISQATQERLRGLLEKLTAIAQHRMTTYKASENYILCSDTRSQLKFLEKLDQLEKQRKDLEEREMLLKAAKSRSNKEDPEQLRLKQKAKELQQLELAQIQHRDANLTALAAIGPRKKRPLESGIEGLKDNLLASGTSSLTATKQLHRPRITRICLRDLIFCMEQEREMKYSRALYLALLK
Protein: Pluripotency associated transcript 25 (A0A1Y7VLW9)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLIHEIKIKYKIWSLLHGCCSLETHSIRDKNAVTYGDVHVNFTQEEWALLDPSQKKLYKDVMLETYRNLNAIGFNWDDKNTEEHCPSTRRWRRYP
Protein: Magnesium transporter MRS2-5 (Magnesium Transporter 3) (AtMGT3) (Q9ZPR4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Magnesium transporter that may mediate the influx of magnesium.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Magnesium/proton exchanger
- Putative non-specific lipid-transfer protein 14
Sequence:
MGEQLDPFSASNLPDFISSQKIGRPVNFEGQTNRGHPFSGLKKRGQSSRSWVKIDQDGNSAVLELDKATIMKRCSLPSRDLRLLDPLFIYPSSILGRERAIVVSLEKIRCIITAEEVILMNARDASVVQYQSELCKRLQSNHNLNVKDDLPFEFKALELVLELSCLSLDAQVNELEMEVYPVLDELATNISTLNLEHVRRLKGRLLTLTQKVQKVCDEIEHLMDDDDDMAEMYLTEKKERAEAHASEELEDNIGEDFESSGIVSKSAPVSPVGSTSGNFGKLQRAFSSIVGSHKSLLSSSSIGENIDQLEMLLEAYFVVVDNTLSKLSSLKEYIDDTEDLINIKLGNVQNQLIQFQLLLTAATFVAAIFAAVTAVFGMNLQDSVFQNPTTFQYVLLITGIGCGFLYFGFVLYFKHKKVFPL
Protein: Transmembrane protein 150A (Fasting-inducible integral membrane protein TM6P1) (Transmembrane protein 150) (Q9QZE9)
Organism: Rattus norvegicus (Rat)
Function: Possible role in fasting-induced catabolism.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10858565}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86TG1}. Note=Localizes mainly at the plasma membrane; only a minor fraction localizes on intracellular structures. {ECO:0000250|UniProtKB:Q86TG1}.
Interaction partners:
- Tetratricopeptide repeat protein 7A
Sequence:
MTAWILLPVSLSAFSITGIWTVYAMAVMNRHVCPVENWSYNDSCSPDPAEQGGPKTCCTLDDVPLISKCGTYPPESCLFSLIGNMGAFMVALICLLRYGQLLEQNRHSWINTTALITGCTNAAGLVVVGNFQVDHAKSLHYIGAGVAFPAGLLFVCLHCVLFYHGATTPLDMAMAYLRSVLAVIAFVTLVLSGVFFLHESSELQHGAALCEWVFVLDILIFYGTFSYEFGAVSSDTLVAALQPAPGRACKSSGSSSTSTHLNCAPESIAMI
Protein: 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Tat-binding protein 1) (TBP-1) (O88685)
Organism: Mus musculus (Mouse)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000269|PubMed:22078707}.
Interaction partners:
- Proteasome subunit alpha type-5
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 5
- Proteasome subunit beta type-1
- 26S proteasome regulatory subunit 10B
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 3
- 26S proteasome regulatory subunit 6B
- 26S proteasome regulatory subunit 8
Sequence:
MQEMNLLPTPESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIVQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
Protein: Manganese resistance protein MNR2 (P35724)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Magnesium transporter MRS2, mitochondrial
- Mitochondrial inner membrane magnesium transporter MFM1
- Magnesium transporter ALR1
Sequence:
MSTDNSQKDEGVPLLSPYSSSPQLRKKKRNQKRRKDKFVGHLKSDSRRPTQLLHDNLQHNHGQITDFDQIDSWGMLHESDSTSNDIIKSEDPSLKGAFIDHRPSMSQPREGPQSVSSTVQPQPIMKFSTPSYKKPAGLRPSDQNRSLVSDLSPSELESWLKRRKSVHKSFVDENSPTDRRQSNANNDVVIDVDALMNHVNNNASTGVNDNSKRRKKKRGSDDSSNKNSKSTSSDSNDEEDEYNSRPSSSLSSNNSSLDDVCLVLDDEGSEVPKAWPDCTVLEEFSKEETERLRSQAIQDAEAFHFQYDEDEEDGTSNEDGILFSKPIVTNIDVPELGNRRVNETENLKNGRLRPKRIAPWHLIQRPMVLGSNSTKDSKSRIQSGLQDNLLVGRNIQYPPHIISNNPEHFRFTYFRVDLDSTVHSPTISGLLQPGQKFQDLFVASIYSQDNSAGHIKTHPNSPTPGIKAETVSQLQGLTAKNPSTLSSMSVANIEDVPPFWLDVSNPTEEEMKILSKAFGIHPLTTEDIFLGEVREKVELFRDYYLICFRSFDIVAEKHVRRRRKEKQESATLDHESISRRKSQAYGATMSNESNANNNNSTSNASRSKWLPSILRARRRSSANRTTNTSSSSYKRRVKSEKKKMEENEKFKRKSGDRHKPREGELEPLNVYIIVFRTGVLTFHFAPTPHPINVRRRARLLKDYLNVTSDWIAYALIDDITDAFAPMIELIEDEVYEIEDAILKMHQSDDSSDSDSSDSDSDSGASDEDAFPFDVYSKKTSYSSAKSSVSSRSMSTSEASFNANLIGWKRKGDMLRRIGECRKRVMSILRLLGSKADVIKGFAKRYNEQWEASPQSEIAMYLGDIQDHIVTMVSSLNHYEKLLSRSHSNYLAQINIDMTKVNNDMNDVLGKITILGTIVLPMNVITGLWGMNVIVPGQYRDSLTWFIGIVLFMCMLACSAYMYTKRRFGF
Protein: Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) (Q7SY37)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR000929}.
Interaction partners:
Sequence:
MTSRRWFHPNITGIEAEHLLLTRGVHGSFLARPSKSNPGDFTLSVRRNDEVTHIKIQNSGDYYDLYGGEKFATLAELVQYYTEQHDLLRERNGDVIELKYPLNCKDPTSERWYHGHLSGRDAEKLLTEKGKSGSFLVRESQSKPGDFVLSVLTNEEKHENVDRKTKVTHVMIRYQDGKYDVGGGERFDTLADLVEHYKKNPMVEESGIVVHLKQPFNATRINAANIENRVHELNKVADNSEKPKQGFWEEFEVLQQQECKLLYPRKEGQRPENKNKNRYKNILPFDTTRVQIKEADPDVPGSDYINANYIRSVNEEGRHMDEGKVFIATQGCLQNTVLDFWKMVYQENTHVIVMTTKEMERGRNKCVRYWPDLNSTKEFGKVCVKNIEEHTAQDYIRRELEVTRLDRREPPRCIWHYQYLSWPDHGVPNEPGGVLSFLEQVNRTQSAIPESGPIVVHCSAGIGRTGTIIVIDILIDIINRQGLDCDIDIPKTIQRVRQQRSGMVQTEAQYKFIYMAVQQYIDTAQKRLEEEQRNKTKEREYSNIKYPQMSNARAKPNMSSSRSSSVMNDDSSVYENLNIKNPKGSTSSNTRR
Protein: Olfactory receptor 2M2 (OST423) (Q96R28)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Olfactory receptor 2M5
Sequence:
MAWENQTFNSDFILLGIFNHSPPHTFLFFLVLGIFLVAFMGNSVMVLLIYLDTQLHTPMYFLLSQLSLMDLMLICTTVPKMAFNYLSGSKSISMAGCVTQIFFYISLSGSECFLLAVMAYDRYIAICHPLRYTNLMNPKICGLMATFSWILGSTDGIIDAVATFSFSFCGSREIAHFFCEFPSLLILSCNDTSIFEEVIFICCIVMLVFPVAIIIASYARVILAVIHMGSGEGRCKAFTTCSSHLMVVGMYYGAALFMYIRPTSDHSPTQDKMVSVFYTILTPMLNPLIYSLRNKEVTRAFMKILGKGKSESELPHKLYVLLFAKFFFLISIFFYDVKILALIMYIA
Protein: Glycerol-1-phosphate phosphohydrolase 1 (EC 3.1.3.21) ((DL)-glycerol-3-phosphatase 1) (Related to HOR2 protein 2) (P41277)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Major isoform of glycerol-1-phosphate phosphohydrolase involved in glycerol biosynthesis. Plays a role in osmoadaptation and required for adaptation to anaerobic conditions.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Glycerol-1-phosphate phosphohydrolase 2
- Glycerol kinase
- Glycerol 2-dehydrogenase
- NADP-dependent alcohol dehydrogenase 7
- Glycerol-3-phosphate O-acyltransferase 2
- NADP-dependent alcohol dehydrogenase 6
- Monoglyceride lipase
- Glycerol-3-phosphate O-acyltransferase 1
- Dihydroxyacetone kinase 1
- Protein YIG1
Sequence:
MPLTTKPLSLKINAALFDVDGTIIISQPAIAAFWRDFGKDKPYFDAEHVIHISHGWRTYDAIAKFAPDFADEEYVNKLEGEIPEKYGEHSIEVPGAVKLCNALNALPKEKWAVATSGTRDMAKKWFDILKIKRPEYFITANDVKQGKPHPEPYLKGRNGLGFPINEQDPSKSKVVVFEDAPAGIAAGKAAGCKIVGIATTFDLDFLKEKGCDIIVKNHESIRVGEYNAETDEVELIFDDYLYAKDDLLKW
Protein: Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) (Q14134)
Organism: Homo sapiens (Human)
Function: Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7644499}. Lysosome {ECO:0000269|PubMed:27695001}. Note=Colocalizes with intermediate filaments.
Interaction partners:
- T-cell receptor-associated transmembrane adapter 1
- Adenosine 5'-monophosphoramidase HINT1
- Segment polarity protein dishevelled homolog DVL-2
- Gamma-butyrobetaine dioxygenase
- Keratin, type II cytoskeletal 5
- Desmin
- E3 ubiquitin-protein ligase TRIM23
Sequence:
MEAADASRSNGSSPEARDARSPSGPSGSLENGTKADGKDAKTTNGHGGEAAEGKSLGSALKPGEGRSALFAGNEWRRPIIQFVESGDDKNSNYFSMDSMEGKRSPYAGLQLGAAKKPPVTFAEKGELRKSIFSESRKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSSPGRFTKETTQKNFNNLYGTKGNYTSRVWEYSSSIQNSDNDLPVVQGSSSFSLKGYPSLMRSQSPKAQPQTWKSGKQTMLSHYRPFYVNKGNGIGSNEAP
Protein: Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) (Q9D826)
Organism: Mus musculus (Mouse)
Function: Metabolizes sarcosine, L-pipecolic acid and L-proline.
Subcellular location: Peroxisome {ECO:0000250}.
Interaction partners:
- Sarcosine dehydrogenase, mitochondrial
- Dimethylglycine dehydrogenase, mitochondrial
- Alanine--glyoxylate aminotransferase
- Glycine N-methyltransferase
- D-amino-acid oxidase
- 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
- Glycine dehydrogenase
- Serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- L-threonine aldolase
Sequence:
MAAQTDFWDAIVIGAGIQGCFTAYHLAKHSKSVLLLEQFFLPHSRGSSHGQSRIIRKAYPEDFYTMMMKECYQTWAQLEREAGTQLHRQTELLLLGTKENPGLKTIQATLSRQGIDHEYLSSVDLKQRFPNIRFTRGEVGLLDKTGGVLYADKALRALQHIICQLGGTVCDGEKVVEIRPGLPVTVKTTLKSYQANSLVITAGPWTNRLLHPLGIELPLQTLRINVCYWREKVPGSYGVSQAFPCILGLDLAPHHIYGLPASEYPGLMKICYHHGDNVDPEERDCPKTFSDIQDVQILCHFVRDHLPGLRAEPDIMERCMYTNTPDEHFILDCHPKYDNIVIGAGFSGHGFKLAPVVGKILYELSMKLPPSYDLAPFRMSRFSTLSKAHL
Protein: Glutathione-independent glyoxalase DJ-1 (EC 4.2.1.130) (Heat shock protein 31 homolog 6) (Protein DJ-1 homolog) (Q10356)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:24758716}. Nucleus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:24758716}.
Interaction partners:
- Putative glutathione-independent glyoxalase hsp3105
- Glutathione-independent glyoxalase hsp3101
- Probable hydroxyacylglutathione hydrolase SPCC13B11.03c
- Lactoylglutathione lyase
- Glutathione-independent glyoxalase hsp3102
- Probable glutathione-independent glyoxalase hsp3104
- Probable glutathione-independent glyoxalase hsp3103
- Superoxide dismutase
- Superoxide dismutase 1 copper chaperone
- Probable hydroxyacylglutathione hydrolase glo2
Sequence:
MVKVCLFVADGTDEIEFSAPWGIFKRAEIPIDSVYVGENKDRLVKMSRDVEMYANRSYKEIPSADDFAKQYDIAIIPGGGLGAKTLSTTPFVQQVVKEFYKKPNKWIGMICAGTLTAKTSGLPNKQITGHPSVRGQLEEGGYKYLDQPVVLEENLITSQGPGTAMLFGLKLLEQVASKDKYNAVYKSLSMP
Protein: Mediator of RNA polymerase II transcription subunit 14 (Mediator complex subunit 14) (F1R9C9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365082}.
Interaction partners:
Sequence:
MAPVQIGSDGQLVPAGGPTSTPQPPPGAPATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAYLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNYIHELVQSRLFGDDKPLQDMYTCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYIPAKCLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPNDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGVDQSMLDDIEKSINDDMKRIVTWLLQLKFWLGEQRCRQSVKHLPTLCTDTLHLSNLTTHPVGNLSKHRLFIKLTRLPQYYIVVEMFDVPSNLTELQYKYYFLSVSQMESEDGLPSAQLFRHFKPNLEELVQDISSCRMVRPGTKRKLSGEQSAVEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRSELSNMEIPHQGVQVEGDGCSHAIRILKVPPCMAVGEETRKALERSLLDCTFRLQGRNNRTWVAELIFSSCPLNSTSIKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISKLYECVLEFSRSLTEMPSYLSLFSEIRLYNYRKLVLCYGSTKGSSVTIQWNSVTHRYHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPISMEDTFMPHTQTQPPGRGVYPPLTSPPNPYHVPPSPSMITTQSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGTLDPSSPYTLVSASPRVGPWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPSHSPRAGTSSQAMPPPRKLPQRSWAASIPTILTHSKLHVLLLPSPMPCPVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLNWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILRRFNEHHPPRPGECTIFAAVHELMANLTLNSGGRP
Protein: isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (Q9VUY4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- Lysine--tRNA ligase
- Probable proline--tRNA ligase, mitochondrial
- Tyrosine--tRNA ligase
- asparagine--tRNA ligase
- Probable glutamine--tRNA ligase
- leucine--tRNA ligase
- leucine--tRNA ligase
- Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial
- Isoleucine--tRNA ligase, cytoplasmic
Sequence:
MLRIFYFRVGNRLYSMKAAKKDAKKYTDTINLPKTKFPNRLTAAKREEQERLVLENKIAVSYAYQEQRLAEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATSTAPGQSAQEIRQKSRAFAWEAIKSQKEEFSSWGILANWQKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAELEYDANHISPSVYVRFALNPSSFDVKDKQIYALVWTTTPWTLPSNQAICYNASLEYVIVRLSDRNQDELYLMASALMADFEANTQLKCEIVQHLSGELLSKLSYNHPIDKEQSNLPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFLRGKSVLDQGNSLVLDRIAEDVVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPRANAEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLNSALIEHLCNLLRKEGSIDFWWVKSVEELVPEHLLRELHHEAKDLVKGTDILDIWFDSGSTWSAVLGKDKIADLYLEGYDQFTGWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITKKYGTDALRWWVASHGTQHMSITVSDKLLQQAAENLCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSYLNRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYCGDDHELLAIRQTLTHCYQQLCKSLWPIVPFLVEESWSYYDTTGGAFHEQIVQTNPEWQDTKATEVINAAFDVKRLINQQAGDVNTWHLAVTIKGKERSQLDLLRELHSPLGESVSNSELCEILQVGSVTLLQSHNSDLDIALSKLQISLCPRCRRYGLEDEQKTCQRCSDVMEAKN
Protein: WD repeat-containing protein 18 (Q9BV38)
Organism: Homo sapiens (Human)
Function: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:21326211}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q4VBE8}. Cytoplasm {ECO:0000250|UniProtKB:Q4VBE8}. Dynein axonemal particle {ECO:0000250|UniProtKB:A0A1L8HX76}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250|UniProtKB:Q4VBE8}.
Interaction partners:
- Testis-expressed protein 10
- Proline-, glutamic acid- and leucine-rich protein 1
- Nucleolar GTP-binding protein 2
- Ribosomal biogenesis protein LAS1L
- Polynucleotide 5'-hydroxyl-kinase NOL9
- Proliferation-associated protein 2G4
- Notchless protein homolog 1
- DNA replication factor Cdt1
- Protein SDA1 homolog
- Sentrin-specific protease 3
Sequence:
MAAPMEVAVCTDSAAPMWSCIVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGPVTNAAILLAPVSMLSSDFRPSLPLPHFNKHLLGAEHGDEPRHGGLTLRLGLHQQGSEPSYLDRTEQLQAVLCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRPAK
Protein: Neurocan core protein (245 kDa early postnatal core glycoprotein) (Chondroitin sulfate proteoglycan 3) [Cleaved into: 150 kDa adult core glycoprotein] (P55067)
Organism: Rattus norvegicus (Rat)
Function: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Subcellular location: Secreted.
Interaction partners:
- Neural cell adhesion molecule 1
- Receptor-type tyrosine-protein phosphatase zeta
- Aggrecan core protein
- Brevican core protein
- Tenascin
- Versican core protein
Sequence:
MGAESVWASGLLVLWLLLLVSGDQDTQDTTTTEKGLHMLKSGSGPIQAALAELVALPCFFTLQPRQSPLGDIPRIKWTKVQTASGQRQDLPILVAKDNVVRVAKGWQGRVSLPAYPRHRANATLLLGPLRASDSGLYRCQVVKGIEDEQDLVTLEVTGVVFHYRAARDRYALTFAEAQEACHLSSATIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRDPQELYDVYCFARELGGEVFYVGPARRLTLAGARALCQRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGSAPGVRTVYRFANRTGFPAPGARFDAYCFRAHHHTPQRGDSEIPSSGDEGEIVSAEGPPAPELKPRLGEQEVITPDFQEPLVSSGEDEPLDLTRTQASQETLASTPGGPTLASWLLTGVTSSTGVPSPSSLGVDMEETTPSGTQVAPTPTMRRGRFKGLNGRHFQQQGPEDQLLEAAEASAQPPTLEVTADHMGPSAATEALESDQSHSPWAILTNEVDVPGAGSLGSRSLPESRKWSPSLISPSTVPSTDSTPGLKPGADEAPGVKSAIHHPPWLPSEPAVPSSIPSEALSAVSLQASPGDGSPDFPIVAMLRAPKLWLLPHSTLVPNVSPIPLSPASPLPSSVPEEQAVRPVSFGAEDPETPFQTTMAAPGEASHGSPEADSIEIEGISSMQATKHPISGPWASLDSSNVTVNPVPSDAGILGTESGVLDLPGSPTSDGQATVDMVLATWLPLPGHGLDTGSQSTPMEAHGVTMSVEPTVALEGGATKDPMEATMDVVPSTVDATSGSEPKSSISSTHVVVTAAGDQGTPTLTPTSSEGQVVAQESLGTLTSLPSHPWSSLASSMDEVASVSSGEPTRLWDIPSTLIPVSLGLDESDLKVVAESPGLEGFWEEVASGQEDPTDPCENNPCLHGGTCRTNGTMYGCSCDQGYAGENCEIDIDDCLCSPCENGGTCIDEVNGFICLCLPSYGGNLCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAERDCRRRAGHLTSVHSPEEHKFINSFGHENSWIGLNDRTVERDFQWTDNTGLQYENWREKQPDNFFAGGEDCVVMVAHENGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLVGVRKVKYNVHATVRYQCDEGFSQHHVATIRCRSNGKWDRPQIVCTKPRRSHRMRRHHHHPHRHHKPRKEHRKHKRHPAEDWEKDEGDFC
Protein: Apoptosis-inducing factor 1 (EC 1.-.-.-) (Cercosporin and photosensitizer-detoxification protein 1) (P52923)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Putative FAD-dependent oxidoreductase involved in the resistance to cercosporin and other singlet oxygen-generating photosensitizers. Translocates from mitochondria to the nucleus under apoptotic conditions, where it degrades DNA and induces apoptosis.
Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:15381687}. Note=Translocates from mitochondrion to the nucleus upon apoptosis induction.
Interaction partners:
- Metacaspase-1
- Mitochondrial nuclease
- Trichothecene 3-O-acetyltransferase
- Putative oxidoreductase TDA3
- Adrenodoxin homolog, mitochondrial
- Pro-apoptotic serine protease NMA111
- Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial
- Cytochrome c isoform 2
- Cytochrome c isoform 1
- Bax inhibitor 1
Sequence:
MTINTKNIVVVGAGVFGVSVANHLYRELGGTYAIKLVTASNYVYFLPSAVRLTVSKDYTKSILPLKNVLDSGIEVIKDTAASFDDKEVVLGSDRAIKFDILVLATGSKWADPIGSTYTFGDNYKEYFEREASRISDADHILFLGGGFVNCELAGELLFKYLEEIRSGKKRISIIHNSDKLLPDSGLYNDTLRKNVTDYLSKNGITLYLNTVGASLDTSPKRIFLGEGSSKYIDADLIYRGVGISPNVPVNSISDLCDKKGFIQVEKNFRVKAVEAGNVFAIGDVTNFRYHGLVKRDNWVDVLTRNVISSLQEGTEASLVDADCLETGHAPSGVSLGPNAGFGQFPLPLLGTINIPSFLISRAKSKNLFSDKMEPLFKK
Protein: Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC) (P43146)
Organism: Homo sapiens (Human)
Function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Netrin-1
- Focal adhesion kinase 1
- Unconventional myosin-X
- Caspase-9
- Cell adhesion molecule DSCAM
- Netrin receptor UNC5B
- Proto-oncogene tyrosine-protein kinase Src
- Netrin-4
- DCC-interacting protein 13-alpha
- Netrin receptor UNC5D
Sequence:
MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLNAITGSAF
Protein: Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphate phosphohydrolase 2) (AcPDro2) (Q9VF36)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Acetyl-coenzyme A synthetase
Sequence:
MAGSGVAKQIFALDFEIFGRVQGVFFRKHTSHEAKRLGVRGWCMNTRDGTVKGQLEAPMMNLMEMKHWLENNRIPNAKVSKAEFSQIQEIEDYTFTSFDIKH
Protein: Cold shock-like protein CspE (CSP-E) (P0A972)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- RNA-binding protein Hfq
- Polyribonucleotide nucleotidyltransferase
Sequence:
MSKIKGNVKWFNESKGFGFITPEDGSKDVFVHFSAIQTNGFKTLAEGQRVEFEITNGAKGPSAANVIAL