wanglab/gogpt-training-data huggingface dataset:
Protein: LP18708p (No circadian temperature entrainment, isoform A) (No circadian temperature entrainment, isoform B) (No circadian temperature entrainment, isoform C) (Q9W2U7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTLGGSRGERNAKPKFTALDINRMYKNSRGESSEPSAQKNQVPRKHGMQILGKVPSARRPPANLPSLKAETHTSSNNNLLVSVEGATSGGAGAGGAAGSGAAGTNTSHNNTTAHSGSSGTSGGAGSGGGGTASSSAGGHLSQQLTHSQHQHNNNVALGPNAGKFVNSNNGSSNNNAGSSGSGNKNFKLINNSVGSSGGGGQGGSGGGGSSGVGGGSGSGSGGHSVNSPKTWSAITTGHERGSGGQNYGRQQQQVVPHYQSPQFQYEFPTLDGTVGSGAGGGSGAGVGSGSGAGKSHYQNQVHHAGHQNHHQHQQHHQQHQQHHHQQQQHHRDYHHGHGRQYGHHSHRDYRDGSDDVGGGSADLGELSLRPQNDTAAWLQQQEKAAKVAAAAAADQGLNLQGPGHHQMGGNGGAGGGSGGAVPLPILSLMPSFMRSGAPMPASGATAASILAGGSLDTSALPNAPYQNGILGARSASPAVVGSGSFRAATAIPKRPPTSSSPPQSGLGIGGSPTPPQSQQQANGGAGGAGRKDKDYVVEPEVAQMQRPIIREEDLERLNAIAKDDSWTKQDDIDFTKKLAFSDDESTPEEHQGQGKQHSSAQLQAQGSSSSTDQRKLSASTTSWQRGKESTDRDQPSEGIQDQQQQLQQQQQQQEVRQQNGHRGSSGNVGAPVAGGIALDASVYERVKQRKEEEERREMERKQAAAKKLQELEMKMNSKKAAAAALAGAEGGVSSASVPLSNEVPPTSAPLGNASEDEGGGQGGGGGLNRRPRGSISSLGSGVTPTGGAGGGGGGVSSSSSAGGDYGQKNFLTHFQSNLPPRFQRQQQQQQQQLPRLEKSASASSAFDSNSRYLQKGGVSGGGGGVSGGAQANAGQGRSISGGYVQRGASVGGSSGYGRNRHDSSSAREDQDLDQQRFTRGQDYRQAQALPRSISENSHRKTSVSSAGDDVLGGSCSSWAEQTDAEQKVHHRHREESFSSSHSHDSAVQIKILQRPARQPSLSEESSTQQKQLPASPQQQKTLTTDPMPTQILRRSVDIDKSGDERAEDKSALESDDKAKSAGKVEEDKSGNKRVSPRSGAACGGRGGRGYAGSSGGSSVGSGSSYRGQRNASDWGSSRGSGGAGGRRYYGSGGEQSEHSEDVDEECYSSGGGGAARRSPKESGNGAPNSGASANKAGFSPRGEPSRRGRGGLSSGGGASASCYRRQPVGTGSAGGSGSGGSGRSYGRLGYEEYGKQQRTSESETDLDKTKQNQLALSAGLHKPSKDDKDLPALGGEEKDKTAALAPAHNTALLAKDELQKDAAGRLPLPPGLAAPGSAVGSVTATSSSVVVPGAADKKKIESCAVVGGEKVTGSKLPAIGEKTSLGAVGSGPSTSLLLDAGAPVNTIIFENSTYKQQAAAASVVTKPGTLSVSSSGATMTVDSLSSALSQMSFGGKATAAGSGDDSQDMKLGFSFGDDPTTPLKVVDNIDKTASQQQQQQQQQHSQQQQQQQQQQNNSTADLNMKIASVKKVWESATPMSDGPSPAQVQQQQQQQPQQQQQSQVQVAAQQQQQQVVGPQQAGDDGSGHMSAASFVAAVAASQHQQQHQQMPHYAVSAVHMQSHHHQQQQQQQQAAVAAAQAQHHQQQQAQAHHQHHALSSPGPVPGSHGHGYSHGSPFDAGSLEQQFQQEDYPSPQQQQQAHQKTKQLQQQQHLGMSPPPSQQQQQQHSQQQQQAQHQQQQQQAHQQQQQQQQPSFYQASPQFGVGGIPTIPSPPAVVYNSSQMPPPSQGGNLYAPFHSLDHSSRSPAYSAAAAAHSYPNPYAAAAAAAAAAAAGGGPFNVNVNAYAMQTPHGGSLPPTAPTPDMYSNLSSQFRLGGGPGPGPGPFGQPSSQQLSNPSNHAAVAIISSSSNSMMSSGAAKPPQSQQTIGAIGSKSAGSGGGPGPGPGPYATTQTYMNLYAAPPPQHPGQGGPPPGAHQLQSNSFYSNSAPGGPSGPQFYGGPPPQGNGGAQSYGLATAAGMYGGHQGGPPGSNGPPGPPQSQHTMGTFNTPFMNSQLLTAASINQYRGGPTPGAAYLKGNQGQTHMQDSMGRQLKSPLSADMSLGLAKQVQSQPSPPHHKNYGAWDLQNQVLQQQQQQSQQQQQQQQRQVGGGNGPSMNALGGRGSGAVGSGSGNGGGGGGGAGGSQVGGNGGGNGVGSVGQSGGGGQGRYPTPIQRPNNYPQHPQQQQQQQQQQQQQREQAAAAAVAAQRAQNMRQVTGAGGGVAGSAGGGGSQTPVGPAGGNGGPGGAGGGGGAGGAAGSGPGKPYYANNASGAAVAANRGEWHAN
Protein: Galactoside O-acetyltransferase (GAT) (EC 2.3.1.18) (Acetyl-CoA:galactoside 6-O-acetyltransferase) (Thiogalactoside acetyltransferase) (Thiogalactoside transacetylase) (P07464)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the CoA-dependent transfer of an acetyl group to the 6-O-methyl position of a range of galactosides, glucosides, and lactosides. May assist cellular detoxification by acetylating non-metabolizable pyranosides, thereby preventing their reentry into the cell (Probable).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:3922433}.
Interaction partners:
- Lactose permease
- Beta-galactosidase
- Lactose operon repressor
Sequence:
MNMPMTERIRAGKLFTDMCEGLPEKRLRGKTLMYEFNHSHPSEVEKRESLIKEMFATVGENAWVEPPVYFSYGSNIHIGRNFYANFNLTIVDDYTVTIGDNVLIAPNVTLSVTGHPVHHELRKNGEMYSFPITIGNNVWIGSHVVINPGVTIGDNSVIGAGSIVTKDIPPNVVAAGVPCRVIREINDRDKHYYFKDYKVESSV
Protein: Serine/threonine-protein kinase CST20 (EC 2.7.11.1) (P0CY24)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: MAP4K component of the MAPK pathway required for the mating pheromone response, and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Required for hyphal formation and virulence.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Cell division control protein 42 homolog
- Rga2p
- Phosphatidylinositol-3-phosphate-binding protein
- G protein subunit beta
- mitogen-activated protein kinase kinase kinase
- Guanine nucleotide-binding protein subunit gamma
- High osmolarity signaling protein SHO1
- Ste50p
- Rho family guanine nucleotide exchange factor
- 14-3-3 protein homolog
Sequence:
MSILSENNPTQTSITDPNESSHLHNPELNSGTRVASGPGPGPEVESTPLAPPTEVMNTTSANTSSLSLGSPMHEKIKQFDQDEVDTGETNDRTIESGSSDIDDSQQSHNNNNNNNNNESNPESSEADDEKTQGMPPRMPGTFNVKGLHQGDDSDNEKQYTELTKSINKRTSKDSYSPGTLESPGTLNALETNNVSPAVIEEEQHTSSLEDLSLSLQHQNENARLSAPRSAPPQVSTSKTSSFHDMSSVISSSTSVHKIPSNPTSTRGSHLSSYKSTLDPGKPAQAAAPPPPEIDIDNLLTKSELDSETDTLSSATNSPNLLRNDTLQGIPTRDDENIDDSPRQLSQNTSATSRNTSGTSTSTVVKNSRSGTSKLTSTSTAHNQTAAITPIIPSHNKFHQQVINTNSTNSSSSLEPLGVGINSNSSPKNGKKRKSGSKVRGVFSSMFGKNKSTSSSSSSNSGSNSHSQEVNIKISTPFNAKHLAHVGIDDNGSYTGLPIEWERLLSASGITKKEQQQHPQAVMDIVAFYQDTSENPDDAAFKKFHFDNNKSSSSGWSNENTPPATPGGSNSGSGGGGGGAPSSPHRTPPSSIIEKNNVEQKVITPSQSMPTKTESKQSENQHPHEDNATQYTPRTPTSHVQEGQFIPSRPAPKPPSTPLSSMSVSHKTPSSQSLPRSDSQSDIRSSTPKSHQDISPSKIKIRSISSKSLKSMRSRKSGDKFTHIAPAPPPPSLPSIPKSKSHSASLSSQLRPATNGSTTAPIPASAAFGGENNALPRQRINEFKAHRAPPPPPSASPAPPVPPAPPANLLSEQTSEIPQQRTAPSQALADVTAPTNIYEIQQTKYQEAQQKLREKKARELEEIQRLREKNERQNRQQETGQNNADTASGGSNIAPPVPVPNKKPPSGSGGGRDAKQAALIAQKKREEKKRKNLQIIAKLKTICNPGDPNELYVDLVKIGQGASGGVFLAHDVRDKSNIVAIKQMNLEQQPKKELIINEILVMKGSSHPNIVNFIDSYLLKGDLWVIMEYMEGGSLTDIVTHSVMTEGQIGVVCRETLKGLKFLHSKGVIHRDIKSDNILLNMDGNIKITDFGFCAQINEINSKRITMVGTPYWMAPEIVSRKEYGPKVDVWSLGIMIIEMLEGEPPYLNETPLRALYLIATNGTPKLKDPESLSYDIRKFLAWCLQVDFNKRADADELLHDNFITECDDVSSLSPLVKIARLKKMSESD
Protein: Protein kinase A catalytic subunit (Q8WSK3)
Organism: Trypanosoma brucei brucei
Interaction partners:
Sequence:
MKSDGCLTRKDVSSWKLQDLEIRETIGTGTFGRVRLCRHRASGQYVVLKILKKQEILRMKQVDHILAESSILQELSHPFIVTMYKGFMDDDRLYLLLEYVVGGELFSHLRKAGKFPNDVAKFYSAEVVLAFEYIHECGIVYRDLKPENVLLDKQGNIKITDFGFAKRVRDRTYTLCGTPEYLAPEIIQSKGHDRAVDWWTLGILLYEMLVGYPPFFDESPFRTYEKILEGKLQFPKWVEMRAKDLIKSFLTIEPTKRLGSVKRGVQDVKRHKFYSGVNWNVLLQRGVAAPIHVRLNNDGDTRYFDRYPESPRHPLQPLTEAQQELFSGFCDGEYTRX
Protein: CRE-UNC-96 protein (H2KZR3)
Organism: Caenorhabditis elegans
Interaction partners:
- Paramyosin
- Protein espinas
- Zinc finger protein unc-98
- LIM domain-containing protein unc-97
- CTD small phosphatase-like protein 1
- Muscle M-line assembly protein unc-89
- LIM domain-containing protein unc-95
- PDZ and LIM domain protein Zasp
- Copine family protein 1
- PDZ domain-containing protein
Sequence:
MSETEDVNLNLDPEKPKVRSVVRSDSGLENEIPKISGTSSALIEEGLSLLNLKSSLSPNVAPVAVDLLDRTCPSPDYGLTSERLASVKTPRFKRIDFDDRLEDLNPNKPAWKSWQENIKDSYHKVKVSAEKKREDNEFMDNMMLGRARPIRGESPYRNLSLDTGFIPSVRSRSSIMGPSLSDRSRLATSSSTTNMFNAGSGPYAAPALTISQGIESRYEERANNVELMLLKNAPLPERYKSITTREFRRAPEPSAGSFSEQDDYDFSHYTTARPYYSRPNRDDPDYFDFDLQHSVDMFKRPEGRYIPRKPQEWENKLISESTGKGTAPLSGHMFTRPDTDWRNNNTSYLSAALRTPKFWEQRFENIGKHVRDSNPISLESINRRIRTLQDIRANRPVTSRFTEYRDPDYDDYEDPLDD
Protein: VIP peptides (Vasoactive intestinal peptide) (B8JIU2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Vasoactive intestinal peptide receptor 2
- Vasoactive intestinal peptide receptor 1b
- Vasoactive intestinal peptide receptor 1a
- Growth hormone-releasing hormone receptor a
- Growth hormone-releasing hormone receptor b
- Growth hormone releasing hormone receptor 2 precursor
- Vasoactive intestinal peptide b.
- Adenylate cyclase-activating polypeptide 1a
- Tachykinin 1
- Calca protein
Sequence:
MCKAMLVRNGAQLLLFITLSSVLYARTLSLPFASMRETRHADGLFTSGYSKLLGQLSARRYLESLIGKRVSDDLMEDQAPMKRHSDAIFTDNYSRFRKQMAVKKYLNSVLTGKRSQEDPPSMQEESAGGETTYRESYDDVTVDRLLNHIPLPL
Protein: Cytochrome P450 monooxygenase cicH (EC 1.-.-.-) (Cichorine biosynthesis cluster protein H) (C8V0D4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of cichorine, a phytotoxin active against knapweed, corn, and soybeans. The first step in the pathway is performed by the non-reducing polyketide synthase pkbA that condenses one acetyl-CoA starter unit with 3 malonyl-CoA units. PkbA also catalyzes one methylation step to produce 3-methylorsellinate. The nonribosomal peptide synthase-like protein cicB, the cytochrome P450 monooxygenase cicH and the O-methyltransferase cicE are involved in the conversion of 3-methylorsellinate into nidulol. CicB converts 3-methylorsellinate to a yet unidentified intermediate, cicH may play a ring-closing role for cichorine and cicE is plausibly responsible for the methylation of one of the phenol groups (Probable). The oxidoreductase cicC acts downstream with still unidentified enzymes to further convert nidulol into cichorine.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAILVRLFFALFVVSVYFFRVRLRLSHIPGPFLASLTNINRRQWVTTGRAHTIHTELHRQYGKVVRAGPNTVFVSDPAAIPAIYRFNEPYQKSEFYDALMPYVRGKSIPDVFATRDEHIHRTMKQPIAAIYSMSNLVSFEPYVKSTIEYFFSRLDSLFVETGKVCNFGLWLHLFASDVMGEITFSRRLGFLETGGDMENVMANNWKFFVQAAPATQMPWLDYFWKRNPLLPGSVKPNKVIEFGVARIQERLHLSEKHPDHVNSRDFLSRFIAAKEKNSQIGPDAIMTWANSNIQAGSDTTAILLSALFYHLLKNPTSLAALCTEIDAAAKRGCLSSILTWKETRDLPYLDACVKEAARLHPPISLPLERVIPESGTVIGGFKIPGGTRVAMNPWAVHRDRDVFGADADTWRPERWLEGEEKAKTLYNSLLTFGGGHRSCLGKNISYLEIYKLVPSILLRYEIGLAEPEKEWHLENRWFVMPSRFYVRLKARNGVTKL
Protein: FHA domain-containing protein (P96214)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- ESX-1 secretion-associated protein EspE
- ESX-1 secretion system protein EccA1
- ESX-1 secretion-associated protein EspF
- ESX-1 secretion-associated protein EspH
Sequence:
MAGERKVCPPSRLVPANKGSTQMSKAGSTVGPAPLVACSGGTSDVIEPRRGVAIIGHSCRVGTQIDDSRISQTHLRAVSDDGRWRIVGNIPRGMFVGGRRGSSVTVSDKTLIRFGDPPGGKALTFEVVRPSDSAAQHGRVQPSADLSDDPAHNAAPVAPDPGVVRAGAAAAARRRELDISQRSLAADGIINAGALIAFEKGRSWPRERTRAKLEEVLQWPAGTIARIRRGEPTEPATNPDASPGLRPADGPASLIAQAVTAAVDGCSLAIAALPATEDPEFTERAAPILADLRQLEAIAVQATRISRITPELIKALGAVRRHHDELMRLGATAPGATLAQRLYAARRRANLSTLETAQAAGVAEEMIVGAEAEEELPAEATEAIEALIRQIN
Protein: U-box domain-containing protein 19 (EC 2.3.2.27) (Plant U-box protein 19) (RING-type E3 ubiquitin transferase PUB19) (O80742)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as an E3 ubiquitin ligase.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 8 homolog A
- Glycosyltransferase
- Putative RING-H2 finger protein ATL61
- Probable protein phosphatase 2C 73
Sequence:
MIHTPTGSSRRILTFPAVNPCESISLTTLVDSLLQLAGEILSFKPKHFSTNKRSVKETLRHVQTLVIFFEELRIQIRVGSIPAGRSVILSLSELHVIFQKLKFLLDDCTRDGAKLYMLMNSGQVSAHFRDLTRSISTSLDTFPVRSVDLPGEVNELIYLVMRQTRKSEARPDRDDKRAIDSVYWFFNLFENRINPNSDEILRVLDHIGVRKWRDCVKEIDFLREEISVGKKSNIEIELLSNLMGFICYCRCVILRGIDVDDEEKDKEEDDLMMVRSLNVDDLRCPISLEIMSDPVVLESGHTYDRSSITKWFASGNITCPKTGKTLVSTVLVDNFSVKQVIQSYSKQNGVVMGQKGKKKVDVAESLAAEEAGKLTAEFLAGELIKGDEEEMVKALVEIRILTKTSTFYRSCLVEAGVVESLMKILRSDDPRIQENAMAGIMNLSKDIAGKTRIVGEDGGGLRLIVEVLNDGARRESRQYAAAALFYLSSLGDYSRLIGEISDAIPGLVRIVKSCDYGDSAKRNALIAIRSLLMNQPDNHWRILAAGIVPVLLDLVKSEEISDGVTADSMAILAKMAEYPDGMISVLRRGGLKLAVKILGSSEVSPATKQHCVALLLNLCHNGGSDVVGSLAKNPSIMGSLYTASSNGELGGGKKASALIKMIHEFQERKTGPGEPVLERERFVHAW
Protein: Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) (O14776)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.
Subcellular location: Nucleus {ECO:0000269|PubMed:10908677, ECO:0000269|PubMed:15485897, ECO:0000269|PubMed:9315662}.
Interaction partners:
- Pre-mRNA-splicing factor 38A
- Microfibrillar-associated protein 1
- Splicing factor 3B subunit 4
- Zinc finger matrin-type protein 2
- Splicing factor 3A subunit 1
- Splicing factor 3B subunit 1
- U2 small nuclear ribonucleoprotein A'
- Splicing factor 3A subunit 3
- SNW domain-containing protein 1
- Cell division cycle 5-like protein
Sequence:
MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGMPPVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPTTQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVPQPTTAIPAFPPVMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIAASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEPSEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKWQFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLEARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERREKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLFKQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAIQNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREHFRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYITAKADFRTLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYVDDLDRRGPPPPPTASEPTRRSTK
Protein: Cytosolic 5'-nucleotidase 1A (cN1A) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.99) (5'-deoxynucleotidase) (Cytosolic 5'-nucleotidase IA) (cN-I) (cN-IA) (Q9BXI3)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside. AMP is the major substrate but can also hydrolyze dCMP and IMP.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:7599155}.
Interaction partners:
- Cytosolic purine 5'-nucleotidase
- 5'
- 5'
- Cytosolic 5'-nucleotidase 3A
- Deoxycytidine kinase
- 7-methylguanosine phosphate-specific 5'-nucleotidase
- Purine nucleoside phosphorylase
- Deoxycytidylate deaminase
- 5'-nucleotidase
- Uridine phosphorylase 2
Sequence:
MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSRALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSEDVFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTAPAKQAPSAQ
Protein: Receptor mediated endocytosis 8, isoform A (A1Z7S0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Vacuolar protein sorting-associated protein 35
- FI18122p1
- Vacuolar protein sorting-associated protein 29
- Cyclin-G-associated kinase
- Vacuolar protein sorting-associated protein 26
Sequence:
MLPPKENVDLECFLVTKHSWKGRYKRILSIGTAGISTYNPDKLDLTNRWSYSDIVAAAPSKTTNIPHDFVITIKKDKKLDTIKLSSEYRNDILSSILKYYKEFADKPKNAQRFSAYKYHWSGISLPTVLEVTPCSLDQLDPTTNDVLASYMYKDIEGIIAGISDYEGGIVMAYGGFSRLHLFKALNHHEIVQNIAQRSAQFLGIETKILKSQITLEQFERQRFGKFSGDQFQTSSTEFSVHKITPRHPDPVKRILCLTEVTLLERDPQTYSVCTLRPLTDVFALVRDKDNLQRFSIEYKNGIVRNYSTNDRDSLLATVLDAVRSSGNQDVHVRIGNTPRGKRYVPLNSSVDEETEANLMRLVINNFQNPSKRYEILERFNANVPHSGLNYSVTQDSLFAENKDKLILSALQALAQKELDSPTAQLSNLELEAIFHALTRLLASKVGYAAFTNLPGFREIIGTKVVAALRRKDLAVTYSAIDMINSLMHSVNSDHDLKQEQLNKSSILSSKSFLETLLNMWTTHVSHGSGALVLSAMLDFMTFALCVPYSETTDGKQFDTLLELVADRGRYLYKLFQHPSLAIVKGAGLVLRAIIEEGELQVAQQMQALALDEAALCRHLLVALYTPSNDPTQTTQRQLSRHLIGLWLTDSEEAMELFKRIFPAGLLTFLESEETVPESDVEEDKLNFRDNLKFAIQHSNKTRKNVIEKHLQGIKHWGMNLIEKQDGAAQALKNRPVVLRNRRQKKKTSDVVVNLPFFFYSFAKDHSLPNLIWNHKTREELRMCLENELRQFLNDRDLAGQMIVAWNYQEFEVAYQCLADEIKIGDYYIRLILEKDDWPQNLVKDPIELFNALYRRVLCRQRVNDDQMTVFSLQALAKVYRRYHAEIGKFNDMSYILQLSDRCLSPSMRDALINLISCLVLEKSNSRALIDHVQCLVDLITLAHLHKGRAQLNTKTNVIEAGPNMGTYEEKDWYYNIEKDGQKPERQGPITYSELKELWQKGLITPKTRCWAIGMDGWRSLQQIPQLKWCLIAKGTPLYDETELSSKILDILIKCTSFFPSRTQNGVAVLIPGPKLSRKLSEFICLPHVVQVCLTHDPGLLERVATLLYQIMEDNPEMPKVYLTGVFYFMLMYTGSNILPITRFLKMTHMKQGFRSEETSQSGIMHRSILGQLLPEAMVCFLENYSAEKFAEIFLGEFDTPEVIWSSEMRRLLIEKIAAHIADFTPRLRGHTMARYPYLAIPVISYPQLENELFCHIYYLRHLCDTQKFPNWPISDPVQLLKHTLDAWRKEVEKKPPQMTIQQAYQDLGIDLTKTPKPDESMIRKSYYKLAQMYHPDKNPNGREIFEKVNQAYEFLCSRNVWSSGGPDPNNIVLILRTQSILFERYPDVLRPYKYAGYPQLIKTIRLETRDDELFSKEAQLLTAASELCYHTVHCSALNAEELRREEGIEALLEAYTRCVSILGVDSKPDSLHYQVISNVTRCFEVACNFEKCKQKIIQLPQLLSDVCRVVYFKHTLSVSLVTSLAANNYDLQCQLSRNGVLWSLLLFIFEYDYTLDESGVDVSDKSNQQQLANNLAKMAVLGCIALAGYSMELRQKPVTGSETNSPAAKAPPVIKPKPSVSAASSSTYTQNAHNPLQSKQLAITSGKEKESDTSSGSSDTASSTPTESEQQQQLTKTRTSAIQQKYIVTGEAKNSLIKQVLDRLLTRYISNQLATVRDSDVLKLLTANTRNPYLIWDNGTRAQLKDFLEQQRTASAKETHEDIAQVSELVSSFEFDAHKDELQIGGIFIRIYNDMPTHPIAQPKLFIMDLLEYLKHAYQFLQYKKNPASTAAPVNATPKMGNDGILTPTLAPNHPQLQQASTGKSGTTFDEVLTAYNRSKSRKKLETDALTEQQLALQQSKYDFSSDGKIELHITMVLKALIAVIKANAEVEIQCIGNFDMIFGFLASNIFPDNSTVKAVALEVVSLVSRNKECVSEVAACEILGNYLVALKDPELRASQVKVLETLSGLMNVQEMIKEAQAKGATIYLLDMFCNSRNPQIREMCAGILAKMTADRLSGPKVRITVSKFLPALFIDAMVESPATSVQLFESIHEHPELIWNDTTRSNVCDAVADTCQRFYQLQKANSRHVWKDPEILKDIVSNEIVVAGVYLRLFVSNPAWTLRKPKQFLSDLLDFVVEQIGKSSSEQDVLDLSTTALVELLRSQPNLADDIPVLGHIPKLFNLLSVQPKNTLSVLHQLSLSEFCVSAISQTECVAPLKKCMEHNRDCIEKACEALSRLFKHQHDSLISQSLEVGLIPFLLGLLDSRLEFVDNPSAVKAQIVAALKGMTHNLNYGDRVTQILLKHPVWAEFKDQRHDLFIADTTIRGYLTGVNPTAGYLTAGPAQSVEVLTSPPPIDRDDPSARPPID
Protein: Hexose transporter HXT16 (P47185)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable glucose transporter.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Carbon catabolite-derepressing protein kinase
Sequence:
MASEQSSPEINADNLNSSAADVHVQPPGEKEWSDGFYDKEVINGNTPDAPKRGFLGYLIIYLLCYPVSFGGFLPGWDSGITAGFINMDNFKMNFGSYKHSTGEYYLSNVRMGLLVAMFSVGCSIGGVAFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYGTRKYSNTAQWRIPVGLCFLWALIIIVGMLLVPESPRYLIECERHEEACVSIAKIDKVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENYFFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAASMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSKAMSISTAFNWLWQFLIGFFTPFITGSIHFYYGYVFVGCLVAMFLYVFFFLPETIGLSLEETQLLYEEGIKPWKSASWVPPSRRGASSRETEAKKKSWKEVLKFPKSFN
Protein: Haemolysin-III related (Q57VK0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- CRAL-TRIO domain-containing protein
Sequence:
MEVELEPFASWLVCILSVVSHATLVPTVYHFLRKRYAYESVLGIFGLTASLMYHICEAFDAKFFMSSLAWHRVDNILVISLLGAWSVYMCALHDPFVERFTKYSLMMLCLIFQTRGPWEAVNSVFPAAVSFSIPIGVYVYRRRIPALEIGRLVGFILIMAVAVIFFIKGLDDKRDHFRMYHSTWHFFCGIASYLMWTLLKVPGVTGVMGKSIHV
Protein: ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] (P12236)
Organism: Homo sapiens (Human)
Function: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P02722}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:27641616}; Multi-pass membrane protein {ECO:0000255}. Note=The complex formed with ARL2BP, ARL2 and SLC25A6/ANT3 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (By similarity). {ECO:0000250|UniProtKB:P12235}.
Interaction partners:
- Non-selective voltage-gated ion channel VDAC1
- Non-selective voltage-gated ion channel VDAC2
- Non-selective voltage-gated ion channel VDAC3
- ADP/ATP translocase 2
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Cytochrome c
- Cytosolic iron-sulfur assembly component 2B
- Peptidyl-prolyl cis-trans isomerase D
- Mitochondrial import inner membrane translocase subunit Tim10
- Translocator protein
Sequence:
MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI
Protein: Polycomb complex protein BMI-1-A (Polycomb group RING finger protein 4-A) (Q8JIR0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2.
Subcellular location: Nucleus {ECO:0000269|PubMed:12051733}.
Interaction partners:
- E3 ubiquitin-protein ligase RING2
- Chromobox homolog 4
- Chromobox homolog 2
- Histone-lysine N-methyltransferase EZH2
- Chromobox homolog 8a
- Polycomb protein suz12-A
- Polycomb protein suz12-B
- YY1-associated factor 2.
- Chromobox homolog 8b.
- Polyhomeotic-like protein 2
Sequence:
MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKMCIVRYLETSKYCPICDVQVHKTKPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAEHPSVDAANGSNEDRGEVADEDKRIITDDEIISLSIEFFDHRAQQQGCTEERQKEEVNNKRYLQCPAAMTVMHLRKFLRSKMDIPPTYQIEVMYEDEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPSCKKMKITHPQEGLNNANRSESDSASDKACSPAGVPSTSSPLPSPSTLVQPSQPHFTHISSPINGTTMTSPNRQFNFSKVRKSALNGSSTSSG
Protein: Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) (A0A140VJL3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU364099}.
Interaction partners:
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA