wanglab/gogpt-training-data huggingface dataset:
Protein: Notchless protein homolog 1 (Q9NVX2)
Organism: Homo sapiens (Human)
Function: Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|Ref.5}.
Interaction partners:
- Ribosome biogenesis protein NSA2 homolog
- Nucleolar GTP-binding protein 2
- Protein SDA1 homolog
- WD repeat-containing protein 18
- Ribosome biogenesis protein NOP53
- GTP-binding protein 4
- Midasin
- Proliferation-associated protein 2G4
- mRNA turnover protein 4 homolog
- Zinc finger protein 593
Sequence:
MAAAVPDEAVARDVQRLLVQFQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSSLGKTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR
Protein: Hepatic leukemia factor (Q8BW74)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Period circadian protein homolog 3
- Nuclear factor interleukin-3-regulated protein
- Period circadian protein homolog 2
- Basic helix-loop-helix ARNT-like protein 1
Sequence:
MEKMSRQLPLNPTFIPPPYGVLRSLLENPLKLPLHPEDAFSKEKDKGKKLDDESSSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
Protein: Large ribosomal subunit protein eL19 (60S ribosomal protein L19) (P84099)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}.
Interaction partners:
- Small ribosomal subunit protein eS4
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein eL21
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein eL20
Sequence:
MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK
Protein: Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) (P13542)
Organism: Mus musculus (Mouse)
Function: Muscle contraction.
Subcellular location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Interaction partners:
- Myosin light chain 1/3, skeletal muscle isoform
- Troponin I, fast skeletal muscle
- Troponin T, fast skeletal muscle
- Troponin C, skeletal muscle
- Myosin light chain 3
- Myosin light chain 4
- Alpha-actinin-3
- Tropomyosin beta chain
- Titin
- Myosin-11
Sequence:
MSAGSDAEMAIFGEAAPYLRKSEKERIEAQNKPFDAKTSVFVAEPKESYVKSVIQSKDGGKVTVKTESGATLTVKEDQVFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQCLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPTKGKAEAHFSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADGGAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGYLMRVEYQKMLLRRESIFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDENIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVEMNKKRETEFQKLRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLSSNAEAIAKAKGNLEKMCRTLEDQVSELKSKEEEQQRLINELTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKRQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKVLSEWRQKYEETQAELESCQKESRTLSTELFKVKNAYEESLDHLETLRRENKNLQQEISDLTEQIAEGGKHIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHVRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE
Protein: Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) (Q6ZUM4)
Organism: Homo sapiens (Human)
Function: Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Cell division control protein 42 homolog
- SH3 domain-containing kinase-binding protein 1
Sequence:
MAADVVGDVYVLVEHPFEYTGKDGRRVAIRPNERYRLLRRSTEHWWHVRREPGGRPFYLPAQYVRELPALGNPAAAAPPGPHPSPAAPEPLAYDYRFVSAAATAGPDGAPEESGGRASSLCGPAQRGAATQRSSLAPGLPACLYLRPAAPVRPAQSLNDLACAAVSPPAGLLGSSGSFKACSVAGSWVCPRPLARSDSENVYEVIQDLHVPPPEESAEQVDDPPEPVYANIERQPRATSPGAAAAPLPSPVWETHTDAGTGRPYYYNPDTGVTTWESPFEAAEGAASPATSPASVDSHVSLETEWGQYWDEESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
Protein: Protein SIS1 (P25294)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for nuclear migration during mitosis. It is required for the normal initiation of translation. Might mediate the dissociation of a specific protein complex of the translation machinery. Essential for viability.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. Note=Localized throughout the cell but is more concentrated at the nucleus.
Interaction partners:
- Heat shock protein SSA1
- Heat shock protein 104
- Heat shock protein SSA4
- Heat shock protein homolog SSE1
- Heat shock protein STI1
- Heat shock protein SSA2
- [PIN+] prion protein RNQ1
- Hsp70 nucleotide exchange factor FES1
- Heat shock protein SSA3
- ATP-dependent molecular chaperone HSP82
Sequence:
MVKETKLYDLLGVSPSANEQELKKGYRKAALKYHPDKPTGDTEKFKEISEAFEILNDPQKREIYDQYGLEAARSGGPSFGPGGPGGAGGAGGFPGGAGGFSGGHAFSNEDAFNIFSQFFGGSSPFGGADDSGFSFSSYPSGGGAGMGGMPGGMGGMHGGMGGMPGGFRSASSSPTYPEEETVQVNLPVSLEDLFVGKKKSFKIGRKGPHGASEKTQIDIQLKPGWKAGTKITYKNQGDYNPQTGRRKTLQFVIQEKSHPNFKRDGDDLIYTLPLSFKESLLGFSKTIQTIDGRTLPLSRVQPVQPSQTSTYPGQGMPTPKNPSQRGNLIVKYKVDYPISLNDAQKRAIDENF
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (B1NA68)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase kinase kinase 7.
- Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase.
- Mitogen-activated protein kinase 8
- Stress-activated protein kinase JNK
- Stress-activated protein kinase JNK
- Dual specificity mitogen-activated protein kinase kinase 7
- Crk-like protein-like)
- Non-specific serine/threonine protein kinase.
- Arrestin, beta 2a.
Sequence:
MATSSPSSNPASASNNPTQLHPAQSQHITTMSSMQGFQINLSGLPPSKRKALKLNFANPPIKTTSRITSGLPFQNPHIERLRTHSIESSGKLKISAEQHCDFTAEDLKDLGEIGRGAYGSVNKMAHKPSGQIMAVKRIRSTVDEREQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSSLDEVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSSSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHAFIQMYEERSVDVATYVCRILDQMPPSPSSPMYVD
Protein: Kank, isoform D (RE07910p) (A8DYE0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Kinesin-like protein at 31E, isoform A
- Rhea, isoform B
Sequence:
MSVRPNNAGDMLLHNSVIGGYDESKFAEKITHLTPTEQEAVKRFWRSLVLRSQRAFIEENARPIASSANPAPAGITRSVRSCNCCPYGYHIDLDFVRYCEALALEKPSEEEQRRRDRRRSRKSMEFMLGFESLFGGDWQAESRVQGKLSETSHESEPDSPHPIGGGGSLHMSQSYTTTPCYRPRSSSVPRFTYGSIPPRSESPFGTASSTCSSLRGGVESDAGIYHQRHRPAISPPETRAFLHEALDEVCSDFERTLERTSVKRRKSPYGAGSLSMDRNNNKLSLSISNGHGALKELKSHRLGNSTWDRHFDVADSCIGGNQSPTGTPRPFLRSNTLPLRQRPSPAEVQYESYVQATVAANAKSPVEQLESAKSPGAPPPPPPRRHHLLATTPTGKPTFKEDRPQENGSVSSSSLQSPVISETGQTTADAQALFQIREQMALSLRRLKDLEEQVKVIPDMELELNSLRSEKQKLLRRNEELMRSQRQTPSPPSPGLKTASPVQFTPQRISPVSLESLGARMRSSSTSASPSPSVVRRDVSTQAVVRPPATRDVSVGHQPTTRNVGVQPSETVYSKEELDKKVEQALTNAQKQQLRKLISVGTQMYVPQRDQKDSGVQTTPERPKLKYHVGVTVKPATRENFTSCKPDVRHVGSSDDRLDDVLCEKCAVSKRSVACGPETPAEKVKPAPQMPGRSNTFSLGENETVSVVRKTIGCQTPVTLVLSSGSQTTTAVVRSTGAQVNPQQQHSGVQCATEQVSRQTDTKGLQRLTRSQTKAEQVSESVPRPTTRHTASNTDKVEEAEPAKVRTSHSACNTEEVRKRDVGCGDIVKPHISIACAANYCDSCKEAIQDLARGFSKASPTATRTGGAVRRSTSADSRIPRPKHLSSPSPVRKEFMRQNTYTLATPSPTPSPQVERKARLSSLQEKPPSVSSFQASEPLPESQSFIRQPQKDSLDLSLLGEDELIVREEKRVSISWSRDASPAPLMTSSGTTKSESPEQEPAMSSSSDSSPPIDVQIAQGARKKSSTPLKSSQSEGSQVTVIEQPATKAQLHQLAQADSEPRKKTELSQSLKDALKIINDSLLKKLGAKPISSQSLKSAKATIQDHWFTNSSTGKSDPHQVEDYLDYFESLSIPLLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLIYVHEQMLRSKLPNRGDATRSSLISPPRHKRQPSQ
Protein: Voltage-dependent calcium channel type A subunit alpha-1 (Protein cacophony) (Protein nightblind A) (Protein no-on-transient B) (Dmca1A) (P91645)
Organism: Drosophila melanogaster (Fruit fly)
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine-insensitive current. Vital for survival to adulthood.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein.
Interaction partners:
- RIM-binding protein, isoform F
- Straightjacket, isoform C
- Ca2+-channel-protein-beta-subunit, isoform L
- Voltage-dependent calcium channel type D subunit alpha-1
- Uncoordinated 79, isoform C
- Stolid, isoform H
- Bruchpilot, isoform J
- Ca[2+] channel Muscle-specific alpha2/delta subunit, isoform A
- Ca[2+]-channel protein alpha[[1]] subunit T, isoform F
- GH12419p1
Sequence:
MGGPKKEENPPGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFSNERNRVERRMEFQKCRFRAMFQTAMVSYLDWITQAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGHDDSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDREREVERERLEYIAPLSFEQALAMGRTGRVLPSPVLNGFKPKSGLNPRHSDSDEEDWC
Protein: Solute carrier organic anion transporter family member (Q9VK84)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU362056}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU362056}.
Interaction partners:
Sequence:
MAEVKRRDPNRPPGHYLCGMANWHPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNTFSMTQAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGRNLDIYGDKEAKEEERANRKDQPITPLLAKKSEQE
Protein: Wax ester synthase/diacylglycerol acyltransferase 10 (WS/DGAT 10) (Diacylglycerol O-acyltransferase WSD10) (EC 2.3.1.20) (Long-chain-alcohol O-fatty-acyltransferase WSD10) (EC 2.3.1.75) (Q9FK04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional wax ester synthase/diacylglycerol acyltransferase (By similarity). Involved in cuticular wax biosynthesis (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5KS41}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q93ZR6}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MTKEEVEEEPLSPMARLFQSPGIENCIITMIGFKAKINPDIILDDLKHNVSKHPRFCSKLVIATHTNYDGERWMKTKVNVEDHVFVPDIDLQEINKDGDGFVDDYVSRLTLSPLDKSKPLWDIHILNVKTSDAEAVGVMRCHHSLADGMSLMSLLVACTRKTSNLESFPTIPAIKRREQMMSHRFGNKGWYSRSINAVYYAVRLIWNTIVDLLLLWATSLFFKDTETPISEGIGSGNNARRFYHRTVSLDDIKLIKNAMKMTINDVLLGVTQDALSRYLNQRYGDKNGEGVTTTSNLNNLPGKIRIRAGVAVNLRQDIGIQPLEDMLAKDSKCRWGNYDSLVFVPFSISLETDPLVPLLKAKSIMDRKKHSLVAPMHYSIIEFIINTFGTKVFNRTCSNTTTILSNIVGPVEEVSLHGNCITYIALTGYGHSQALMIHFISYANKMIITIAVDPAVIPDPHNICDEMEKSLKAMKDTLSGKSD
Protein: Activated in Blocked Unfolded protein response (O16511)
Organism: Caenorhabditis elegans
Interaction partners:
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Chitin-binding type-2 domain-containing protein
- Activated in Blocked Unfolded protein response
Sequence:
MRFTTLAVAFFACALVVSGSVLREKRQCGCAQPQQSQCSCQQVQQTQSCSCQSAPVQQQSPSCSCAQPQQTQQVQVQSTQCAPACQQSCQQQCQASPSVSQCQPQCQQQCQAQCTPMYNPPTTTTTTQAPVVQYQQCQPVCQQQCQSTCVQQQQPAAQCQPQCQQQCNVACDSPSTTTQAPQVIQIQLEIQQAQAQCQPQCQQQCQSSCVQQQQPSTQCEPACNTQCSDICQQTAQATQQVYNNNQNMNQNMNQNTNTQMYNPYNTNTNQGSANCAPACQPACDNSCTSQQAQPVYQQAQPTYQVQQTTAAPMYDPYNNQGSANCAPACQPACDNSCTSQQTQPMYQPYDTTTEAPAQVIQIVLQTSVAQSSQCAPQCEQSCQQQCVQQQQPAAQCQTACQSSCSNSCQAAQPATTACQQSPQQSSCSCQTNYSPCGNGQCCRRK
Protein: Leucine-responsive transcriptional regulator (A0A1D8PND3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Topoisomerase 1-associated factor 1
- non-specific serine/threonine protein kinase
Sequence:
MNNNVASSQNSGKSSLDNLVHIASNMSQEFRLPNRPSIPPNQSLSQTPLNQQPASEYNSATSTPSPSMATGSKTKRSKKMACVECRQQKSRCDAFEKRPDPCTRCAKKGLHCDVKSDYKRTYKRARMAQIEKEFEELKKTLTTTQAAELLTKFPSLSSASPDTNPQEETSQIQVKIEPGTSNDTTQGIAGVGVAKTTSNVDLPQHSTKAVEGAYTQQNSTKNTQFTPYRISSHNSSETSQSIPNTPSITRQVESNTRSQIPLAQQEKKVELLDSSLICEEKSVDDISLMPETIKKLYLEYFERYHPILPVVDVSLGPERIYRLCPALFWVIMFVSLRRFPDNSSKSLLVRLSPIVKGILAEIMISPITRYNPIEEDEPIYNVSSVYSVQAFLLYSYWPPITSSLSADSSYNTVGTAFLQAIRIGLHTPTLVNTSEMNKDEKTKHQLTMTHEQLKTWIFCNIASQTIATAFGFPACTQFESSMWFYNQPGSSIIIPRNLQLMMEIAQFEDQMAKALNSNPMDPCGLIDASERLPLLKLLSKRLDTIEITLKNEMLQPSDRRFRVFEILSARVHLLSYYFMDTVRIAQFELQKGLIRLYNAAIALISHTSECQAEDKKFVKYLPGVYLLNLWQAGCIIGKLIHSSLKKFIDVGTGKQSYESVITFTATASILKHDMAYRSSGITRNMWQLFRELDAKKMNSLSIDIRNRMSASVFFDCLKLLRAQVGITKLTTKTDESHPADDDEAIEESQEEVEDEDDQQLAEMGNEKAAPSEDEKNGSLHNVSQKSTPNSTTSSRVRRARTLSNNMDAESKTRKIIRTIPLDPEPISIGASKRSSIFKVVNSSTDSSPIMKSDVSTPNSNRINDHQTRTQTYNPSHVGKQYSQQSPHISSKQTVQSSQYQHHQQQQQPQQLQQHQYEQILQSDNRSYQPAQNISEAPLSQFSAFAFNESPIQLGLENLDIDNFDHDMLWKDVDSVMNDFGFHTS
Protein: N-fatty-acyl-amino acid synthase/hydrolase PM20D1 (EC 3.5.1.114) (EC 3.5.1.14) (Peptidase M20 domain-containing protein 1) (Q6GTS8)
Organism: Homo sapiens (Human)
Function: Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q8C165}.
Interaction partners:
- Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
- Solute carrier family 41 member 1
- Ras-related protein Rab-7L1
- Solute carrier family 45 member 3
- Argininosuccinate synthase
Sequence:
MAQRCVCVLALVAMLLLVFPTVSRSMGPRSGEHQRASRIPSQFSKEERVAMKEALKGAIQIPTVTFSSEKSNTTALAEFGKYIHKVFPTVVSTSFIQHEVVEEYSHLFTIQGSDPSLQPYLLMAHFDVVPAPEEGWEVPPFSGLERDGIIYGRGTLDDKNSVMALLQALELLLIRKYIPRRSFFISLGHDEESSGTGAQRISALLQSRGVQLAFIVDEGGFILDDFIPNFKKPIALIAVSEKGSMNLMLQVNMTSGHSSAPPKETSIGILAAAVSRLEQTPMPIIFGSGTVVTVLQQLANEFPFPVNIILSNPWLFEPLISRFMERNPLTNAIIRTTTALTIFKAGVKFNVIPPVAQATVNFRIHPGQTVQEVLELTKNIVADNRVQFHVLSAFDPLPVSPSDDKALGYQLLRQTVQSVFPEVNITAPVTSIGNTDSRFFTNLTTGIYRFYPIYIQPEDFKRIHGVNEKISVQAYETQVKFIFELIQNADTDQEPVSHLHKL
Protein: Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Q4KLM6)
Organism: Rattus norvegicus (Rat)
Function: Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IVL5, ECO:0000255|PROSITE-ProRule:PRU10138}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q8IVL5}. Golgi apparatus {ECO:0000250|UniProtKB:Q8IVL5}.
Interaction partners:
Sequence:
MRESTWVSLLLLLLLPAPQRGGPQDGRGSPEPEPERGPLQPFDLLYASGVAAYYSGDYEGAVRDLEAALRSHRRLRDIRTRCARHCAARRPLAPPGAGPGAELPFFRAVLERARCSRSCQSQRLGGPASRHRVSEDVRSDFQRRVPYNYLQRAYIKLNQLDKAMEAAHTFFMANPEHMEMQQNIEDYKATARVEAPLVDREAKPHLESYNAGVKHYEADDFEAAIKYFEQALREYFNEDMVCRALCEGPQRFEEYEYLGSKGSLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLMFHPDDQDVLDNVDFYESLLDDSTDPASIEAREDLTAFVKRHKLEAELIKSAAEGLGFSYSEPNYWISYGGRQDENRVPSGVNMDGAEVHGLSMGKKSPPKIGRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKFGYEGRVPLKSARLFYDISEKARKIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTRGQRCAVALWFTLDPLYRELERIQADEVIAILDQEQHGKHGLNINPKDEL
Protein: Glutamate transporter polyphemus (Q4V5R4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable glutamate transporter which transports extracellular glutamate into the cells. Regulates the production of intracellular reactive oxygen species (ROS) probably by controlling the synthesis of antioxidant glutathione. By regulating ROS production in blood cells, required for maintaining bacteria phagocytosis following infection with S.aureus and possibly E.coli.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24210616}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Palmitoyltransferase
- GH08353p
- Glycerol-3-phosphate dehydrogenase
- Serine/threonine-protein phosphatase
- Reticulon-like protein
- IP12902p
- Receptor expression-enhancing protein
- FI23334p1
- AT01806p
- Male sterile
Sequence:
MEPKSQDQAPNRDDPDLQTEPLTIAQSITSFYMYNPYEKRSVEVPLTNCDAFISLLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAVRIAYEEGPKWINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEIGDHYIERYNERYYVLVACLLLLPLFMIRRLKYLVPLNLISNFLLYAGFALIMYYLFNGLPNINDREMVTPPVEWIEFIAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLAVLFILLSNMFFGIIGYWRFGDNVHASITLNIPQDEILSQFIKVFIASGIFLSYPLNGFVVITVMFSDYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFLNYNVGYGRLMWKLIRDILLILIGLIFGIVGCTVALMQLIRDFQLTLNSM
Protein: Neurexin-1-beta (Neurexin I-beta) (D0PRN2)
Organism: Gallus gallus (Chicken)
Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling (By similarity). Plays a role in angiogenesis.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGGFLRGSPEPGPAGGSGGSAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHSVPIAIYRSPASLRGGHAGTTYIFSKGGGQITYTWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSTGLGDYLELHIHQGKIGVKFNVGTDDIAIEEINAIINDGKYHVVRFTRSGGNATLQVDNWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIKIGGKERGHPFQGQLSGLYYNGLKVLNMAAENDANIVIEGNVRLVGEVPSSMTTESTATAMQSEMSTSVMETTTTLATSTARRGKAPTKEPIGQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGGREYPGSSEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVIKEKQPNSAKSSNKNKKNKDKEYYV