wanglab/gogpt-training-data huggingface dataset:
Protein: WW domain-containing protein (Q388E4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRIACVRLNVGLCRYLAHDAASGVAPPSNGVKDQHAVGRGVVLPAVRAAMCVARPCPMFAATITSNEIPHYDDPCVVWREYFSLQYRKPYYHHLVTNVTTFEVPEGFTTRFPTYHRRQKLFVDEANRVFRNSGSLGVKTNGIVGNTDGFGSSSSSCSGFPPDVNPPPPSGPSPHGVSGLKHKLAAYGAGGLLLYLIVHNILLAIIFFTLYFLHIDVVAYARSYGFKVGKEDGTSEAPSTDVDSGNGKGEKKYPSFWTALALSILLNKLLVPLEVAVTVVLAPRLVPRLQPIAARVIPRVKSIIAGCKAGK
Protein: Uncharacterized protein T1P2.11 (Q9C8R7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT3g07470/F21O3_18
Sequence:
MALREMIIDESDDIESYSDQSLCLDKAKELLALIKLPTGLLPLKDMTEVGYNKTKGFVWMRMRSKIEHTFREIGRRVLYDTEITAFVEDRRMRRLTGVKSKELMIWVPVNDIFIKRKILRRSPLLIPPACHEHLKFQHFNVRVDKLKEKRSNQTSLM
Protein: Aryl hydrocarbon receptor repressor 1 (Aryl-hydrocarbon receptor repressor a) (Q3T2L3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MIPPGDCLYAGRKRRKPIQKQKPAALMSEKSNPSKRHRERLNAELERLAELLPFGPDTVCKLDKLSVLRLSVSYLRIKSFCSVLAQENPCETQTSKNQQDTPAACVPESQLLLESLAGFALVVSGDGMVFYASSTIADYLGFHQTDVMHQNVFDYIHVDDRQEFRRQLHWAMNPPNPEAQSSGTAEEFAVSSLFQSDQPAGVPPELSCFLSRCFILRVRCLLDSTSGFLTMQFQGQLKFLHGQRRRAVSGAALPPALALFCVAVPLLPSGPDLKMRSRQRGPGALPVPQHTDREDPLRRAGTHTLFSRDAVKRRTEGLYAADQPQSVWPRTAPAVDMTARRHTHYGKPSRSAGYSRAECVEFSFQPHGDDYNTHTHLLEPQVKLEPDSDCENGSGACGRYNTHGGACERYNTHGAACERYNTHGAACERYNSAGGHTHMGAQVKLEDGFGQQFSCQRMKPPYAGHYYTPPRPLKCVLNREAASGTLNTHCTDAYTADYRGYMQQDYKAGYEFKGHGLVHSIKQEPLDPQHWDTLMMSCGSGRADTHTCTH
Protein: PICALM interacting mitotic regulator (I3L156)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASRWQNMGTSVRRRSLQHQEQLEDSKELQPVVSHQETSVGALGSLCRQFQRRLPLRAVNLNLRAGPSWKRLETPEPGQQGLQAAARSAKSALGAVSQGINFRSCREGPVRGDLLSNESCCQEDVLILDRIQESCQSGTKWLVETQVKARRRKRGAQKGSGSPTHSLSQKSTRLSGAAPAHSAADPWEKEHHRLSVRMGSHAHPLRRSRREAAFRSPYSSTEPLCSPSESDSDLEPVGAGIQHLQKLSQELDEAIMAEERKQALSDRQGFILKDVYASP
Protein: Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) (A0A494C0T3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU364110}. Nucleus {ECO:0000256|RuleBase:RU364110}.
Interaction partners:
Sequence:
MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Protein: Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (P00191)
Organism: Bos taurus (Bovine)
Function: A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P08686}; Peripheral membrane protein {ECO:0000250|UniProtKB:P08686}. Microsome membrane {ECO:0000250|UniProtKB:P08686}; Peripheral membrane protein {ECO:0000250|UniProtKB:P08686}.
Interaction partners:
- Cytochrome P450 11B1, mitochondrial
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Cholesterol side-chain cleavage enzyme, mitochondrial
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
- Hydroxysteroid 11-beta dehydrogenase 1.
- 11-beta-hydroxysteroid dehydrogenase type 2
- 3-oxo-5-alpha-steroid 4-dehydrogenase
- Steroid sulfatase
- Cytochrome P450 family 7 subfamily B member 1
Sequence:
MVLAGLLLLLTLLAGAHLLWGRWKLRNLHLPPLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGTRSSMEPWVDQLTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLTRHKESMVAGQWRDMTDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSALAFGCGARVCLGESLARLELFVVLLRLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPRGVEAGAWESASAQ
Protein: C-type lectin mosGCTL-1 (Mosquito galactose-specific binding C-type lectin) (mosGCTL-1) (Q17NZ6)
Organism: Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MLTKGITLILLLVLVHSSHGDSTPNRKFYIPSIRANWFKANEFCNSLKMRLVAIRSQEDNDAVARYVRTTSKFTDNCSFWIGASDLADEGTFVWVATGEEVTYTNWRENEPNNEGGNEDCIQLAYIPALNYHWSWNDNTCAGQSLYFICESVECDCVQPF
Protein: Calcium-dependent protein kinase 29 (EC 2.7.11.1) (Q8RWL2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger.
Subcellular location: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- AT5g48790/K24G6_12)
- RNA binding
- Apoptosis inhibitory protein 5
- Calcium-binding protein CP1
- Respiratory burst oxidase homolog protein D
- Flavin mononucleotide hydrolase 1, chloroplatic
- RNA-binding
- DNA repair metallo-beta-lactamase family protein
- Trafficking protein particle complex subunit-like protein
- At1g78070/F28K19_28
Sequence:
MGFCFSKFGKSQTHEIPISSSSDSSPPHHYQPLPKPTVSQGQTSNPTSNPQPKPKPAPPPPPSTSSGSQIGPILNRPMIDLSALYDLHKELGRGQFGITYKCTDKSNGREYACKSISKRKLIRRKDIEDVRREVMILQHLTGQPNIVEFRGAYEDKDNLHLVMELCSGGELFDRIIKKGSYSEKEAANIFRQIVNVVHVCHFMGVVHRDLKPENFLLVSNEEDSPIKATDFGLSVFIEEGKVYRDIVGSAYYVAPEVLHRNYGKEIDVWSAGVMLYILLSGVPPFWGETEKTIFEAILEGKLDLETSPWPTISESAKDLIRKMLIRDPKKRITAAEALEHPWMTDTKISDKPINSAVLVRMKQFRAMNKLKKLALKVIAENLSEEEIKGLKQTFKNMDTDESGTITFDELRNGLHRLGSKLTESEIKQLMEAADVDKSGTIDYIEFVTATMHRHRLEKEENLIEAFKYFDKDRSGFITRDELKHSMTEYGMGDDATIDEVINDVDTDNDGRINYEEFVAMMRKGTTDSDPKLIR
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (G5EHL3)
Organism: Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Magnaporthe oryzae)
Interaction partners:
Sequence:
MPESDNYEVLEKIGHGSFGVIRKVRRKSDGMVVCRKEISYLKMSQKEREQLHAEFQILSTLHHENIVGYFHREHLKSSQDLYLYMEYCGNGDLGRVIRDLQTKNQYAEESFVWSIFSQLVTALYRCHYGINPPEVGKSLFGPVKSTKPVIPPGTMTILHRDLKPENVFLGEGNLVKLGDFGLAKMIQSQDFASTYVGTPFYMSPEICAAEKYTLKSDIWSLGCIIYELCTREPPFNAKTHVQLVQRIREGKISPIPKHYSPDLMEVIKECLRVNPERRPDTATLLHLPHVKMMRKEKELVDCNRMLKQKQEAIRKELNASLHREWEVKARLEIDRILKEEIAGLEKRFEAEVQKRIEEDRQKRPEMDYQKRFEMDYQKRFEADYQKRFDLEFPKKLEEEMRRRYPDTPGSKMDLSWSVPKPKASKSQSSVEEVSADGDESSGPDQPDLSGTSPDSSFSNSNHNEPKRRPRTPYKRAQTMYAGGGRAAGTPMDIEMVSPSPIAIASLSLSPRRHAATTGSPTKNPFSKRNNVQGRTLVELSKARASGRPLFDKSNLISRSEPVATWNPEIDEMPSPFLVRRKGVMPPVSAGR
Protein: RUS family member 1 (Q96GQ5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Diphosphomevalonate decarboxylase
Sequence:
MADDAGLETPLCSEQFGSGEARGCRAAADGSLQWEVGGWRWWGLSRAFTVKPEGRDAGEVGASGAPSPPLSGLQAVFLPQGFPDSVSPDYLPYQLWDSVQAFASSLSGSLATQAVLLGIGVGNAKATVSAATATWLVKDSTGMLGRIVFAWWKGSKLDCNAKQWRLFADILNDVAMFLEIMAPVYPICFTMTVSTSNLAKCIVSVAGGATRAALTVHQARRNNMADVSAKDSSQETLVNLAGLLVSLLMLPLVSGCPGFSLGCFFFLTALHIYANYRAVRALVMETLNEGRLRLVLKHYLQRGEVLDPTAANRMEPLWTGFWPAPSLSLGVPLHRLVSSVFELQQLVEGHQESYLLCWDQSQNQVQVVLNQKAGPKTILRAATHGLMLGALQGDGPLPAELEELRNRVRAGPKKESWVVVKETHEVLDMLFPKFLKGLQDAGWKTEKHQLEVDEWRATWLLSPEKKVL
Protein: Protein FAM9A (Q8IZU1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12213195}.
Interaction partners:
- Synaptonemal complex protein 3
Sequence:
MEPVGRKRSRKAAKAQLEAQVTAAQGATKEGSGIASNFPGQPTMEPVGRKRSRKAAKAQLEAQVRAAPAKKHTGKDPVRDECEERNPFTETREEDVTDEHGEREPFAEKDEHTGIHTMKLEHIAADIKKGLAAKREMIKIDKAAYRKTKNTIERALKKKQLKRQKRDYRHTRKLLNVLKEYIAEKQKDDEAEEAEAAAAAAEAAAAAEAAAAAAEVIVVEDEEEEEKEEEEEKEEEEEEGEEEGGGEEGEEGGGGGEGEETEEEEEEEEEEEEEEQIKAFQEKQKRWQQPTGVRSWRLREMKPLLEQLLKAAKDTKDNYCIISSSEESELDN
Protein: Thioredoxin O1, mitochondrial (AtTrxo1) (O64764)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiol-disulfide oxidoreductase that may participate in various redox reactions. Possesses insulin disulfide bonds reducing activity. Reduced by thioredoxin reductases NTRA and NTRB.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:11717467}.
Interaction partners:
- Thioredoxin reductase 1, mitochondrial
- Peroxiredoxin-2F, mitochondrial
- Thioredoxin reductase 2
- Probable pectinesterase 56
- Probable pectinesterase/pectinesterase inhibitor 42
- Probable pectinesterase/pectinesterase inhibitor 13
- Vacuolar-sorting receptor 5
- Thioredoxin F1, chloroplastic
- Putative pectinesterase/pectinesterase inhibitor 26
- Thioredoxin-like protein CITRX, chloroplastic
Sequence:
MKGNWSIVRKVLHRQFSTLRSSTPSSRLSTSIRPLVLAPNSISSLIARNSLFTASNIGPSIDFNFSNTSLPHRRSLCSEAGGENGVVLVKSEEEFINAMSKAQDGSLPSVFYFTAAWCGPCRFISPVIVELSKQYPDVTTYKVDIDEGGISNTISKLNITAVPTLHFFKGGSKKGEVVGADVTKLKNLMEQLYK
Protein: DEP domain-containing 5, GATOR1 subcomplex subunit (GATOR1 complex protein DEPDC5 isoform X3) (E7EXM8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MTVTMKANKSYKLVVHKKGFGGSDDELMMNPKVFPQVKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVAQAFKLRAYQDVIINIVDPKEVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYVTQKVEFAGIRAQASELWVKGEKVTCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLSDLFAKWKEKNCSHEVTVVLFSRTFYSAKTLEEFPESQRASVRQDHEGRYYEDFYRVVAQNERRDEWMSLLVTIKKLFIQYPVLVRLKGADGFPCGHNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRTVHGDSRIGDDYNLPHWINHSFYTSKSQNSCSCFTPRIKLAGKKVHAEKAKNSKEHSLGAPKDAENSLPIQVDYDAYDSQVFRLPGPSRAQRSTNFRSSRERESVSRKSWGSADVGSSPPNRHTGPDEQRSLASDDSLGHMSNILLIPRPAQGQYEVSSSLGYTSCTRELLEKMVESQRDSSAPGRFTVGSAESTLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEPIQIHHQTRQNMAELQGSEQRDPARTSAELLELAYHEATGSKRTASRHAGENGLYISGVPDNISGSPASSSSTGTPVNRGSFEDYSGSLDPILLLSAPPTVPSFCCTVGVDWKSLTTPACLPLTTDYFPDRQTLQNDYTEGCYDLLPHTDLERRDDETPVMTAHQVFEEFICQRLMQGYQIIVQPNRKPQPAIAPPLSSSPLYSRGLVSRRKPEEEESLYWLSMGRTFHKVCLKDKIITVTRYLPKYPYESTQIQYSYNLCPPHADAHFMPFWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIDSLKFWRTRFLLLPAGGARRVADGEGHWDVYGEGAGAGRDGLAGTGDWTLLDGFIRFLEGLNRIRRRHRSDRMIRKGATIKGLQVTGALTSYTPEPIAPPLGKKGTSALSALLELEQTQKTFEEQQLAAQHGGKPCGPFSEAANVALTTTFVDSPRKDAAFILDFIRSPRSSYICHSQLPAEQVPANPIEGGLSDKISNQPGERTSAASQATGDPTPGASLETGGQSGSSGLSLSSSSTLMEILEAIKHPTTGVQLLPEQRGLPPNCFVSAEVVHWLVSTVENVATQGIAVEIMQKMLEEGLITHASGDAMRTFVYGFYFYRIVDKDNEKAPLTQLPPAGANVWSAAALEDFALFQRKWFEVAFVMEERRPCDLPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQKTVTLDVDVNNRSDRTEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKAASCGFLLVPVLEVPFALSSYLYGDPLRAQLFIPLNIQCLLKEGSDNLFEGFEPETYWDRMQLFQEAILTRFGFVQDKFSASAFNFPSENKPQYIHVTGTVFLQLPYSKRKYSSGQRRRRNSTTSTNQSLFGSEERVGYNWAYNTMLTKAWRTGVLGDEKLADRLLRDFTDFCANKDNRLVTFWESCVEKMNASAP
Protein: Putative C-type lectin-like domain family 1 (C-type lectin-like domain family 1 pseudogene) (Dendritic cell-associated lectin 1) (DC-associated lectin-1) (DCAL-1) (Q8IZS7)
Organism: Homo sapiens (Human)
Function: May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12421943}; Single-pass type II membrane protein {ECO:0000269|PubMed:12421943}.
Interaction partners:
Sequence:
MVSNFFHVIQVFEKSATLISKTEHIGFVIYSWRKSTTHLGSRRKFAISIYLSEVSLQKYDCPFSGTSFVVFSLFLICAMAGDVVYADIKTVRTSPLELAFPLQRSVSFNFSTVHKSCPAKDWKVHKGKCYWIAETKKSWNKSQNDCAINNSYLMVIQDITAMVRFNI
Protein: Prestalk D11 protein (Adhesion modulation protein A) (P05817)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MLNKLILLLILSSCLVLSVKSEVNVDCSLVRCAQPICKPHYRLNMTDSCCGRCEPCTDVACTLQVKYCQDGEVPTGCCPCTLPPTKPDCSLVKCARPVCKPYYRLNMTDSCCGRCEPCTGVACTLQIKYCKDGEVPTGCCPCTPQPTKKPDCSKVPCPKILKYCQEGELPTGCCPCTPQPTKKPDCSRVPCPKILKYCKEGELPTGCCPCTPQPTKKPDCSDVMCTMDIRYCKNGELPTGCCPCTPQETKVPDCSKAMCTMDIKYCKPGEKPFGCCPCRENLTQ
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (Q5BE41)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}.
Interaction partners:
Sequence:
MSEPRQSSENNDSRQPASTPLRRERAPTITIDTSAVVSSEPPPQIEAPSQSSQSRSAYNADHTDTSALLNSSTVSPSDTRSAHSVRSYASSEGREHDSRPTSPSPRTNTFSPGAKMGDSNYLSVPGTRSRGNSLESEDSSHTIGAESRSIGSHGSPASSAKVTIENYEEALLPDPGREAEFEVENNRFAFSPGQLNKLLNPKSLSAFYALGGLAGLAKGLRTDPRSGLSLDETELDGSVSFEDATAPSNNQPLPKPAAEAPPAEPSRADTTPHKQDENAYSDRKRVFGANKLPEKKTKSILELAWLAYNDKVLILLTVAAIISLALGIYQSVTAVPGEPRVQWVEGVAIIVAILIVVVVGAANDWQKERQFVKLNKKKEDRLVKVIRSGKMIEISIHDILVGDVMHLEPGDLVPVDGIYIGGHNVKCDESSATGESDVLRKTPAQDVYGAIERHENLAKMDPFIVSGAKVSEGVGTFLVTAVGVHSTYGKTMMSLQDEGQTTPLQTKLNVLAEYIAKLGLAAGLLLFVVLFIKFLAQLKSLGNADEKGQAFLQIFIVAVTVIVVAVPEGLPLAVTLALAFATTRMLKDNNLVRLLRACETMGNATTICSDKTGTLTENKMTAVAATLGTGTRFGGRSQAASPTNRNGDRPADSGNELSPSEFASSLSKPAKELLLDSIVLNSTAFEGEQEGTMTFIGSKTETALLGFARTYLGLGSLSEARDNASIVQMVPFDSGRKCMAVVIKLDNGKKYRMLVKGASEVLLAKSTRIVRNPTQNLEEGPLDDKDRSKLDETINKYATQSLRTIGLVYRDFTEWPPRGAPTQEEDRSLAAFDSIFKDMVMFGVFGIQDPLRAGVTESVQQCQRAGVFVRMVTGDNIVTAKAIARECGIFTPGGVAIEGPKFRKLSSRQMTQIIPRLQVLARSSPDDKKILVSQLKKLGETVAVTGDGTNDAQALKTADVGFSMGITGTEVAKEASDIILMDDNFASIVKAMAWGRTVNDAVKKFLQFQITVNITAVLLTFISAVASGDEESVLTAVQLLWVNLIMDTFAALALATDPPSPYVLNRRPEPKSAPLINLTMWKMMIGQSIYQLVVTLVLNFSGRSILKSIIDFSGDANANNVLTTVVFNTFVWMQIFNQWNSRRLDNGLNIFDGLFRNRWFIGIQFIIVGGQILIIFVGGHAFSVTRLTGAQWAVCLILGVISIPVGVIIRLIPDEFIRKLIPTFHRKKGPELIVSDEDRRFEWNPALEEIRDQLKFFKSLRGGRLRKVAHKLQHPQELLPRSRSGSRSRENSAPGTPVGDSSEGTPPFSASPDSRSRRRTRSRSNSAFGPAAAMAGVVAGSIAGWSPIERPGEGEAFKFDFNSNGRRSGQPGIEVHPDTAPDDNIIGDYQATSTTPPSQNPDLIPFFEHAPPAREPSHRSRRSRSRSSQSQS
Protein: Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) (Q9GZV4)
Organism: Homo sapiens (Human)
Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P63241}. Nucleus {ECO:0000250|UniProtKB:P63241}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P63241}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63241}; Cytoplasmic side {ECO:0000250|UniProtKB:P63241}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250|UniProtKB:P63241}.
Interaction partners:
- Deoxyhypusine synthase
- Ubiquitin-like protein FUBI
- Deoxyhypusine hydroxylase
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS13
- Large ribosomal subunit protein uL29
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL18
Sequence:
MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELGKEIEGKYNAGEDVQVSVMCAMSEEYAVAIKPCK
Protein: Mpv17-like protein 2 (Q567V2)
Organism: Homo sapiens (Human)
Function: Required for the assembly and stability of the mitochondrial ribosome. Is a positive regulator of mitochondrial protein synthesis.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion inner membrane {ECO:0000269|PubMed:24948607}.
Interaction partners:
- Mitochondrial inner membrane protein Mpv17
- Mpv17-like protein
Sequence:
MARGGWRRLRRLLSAGQLLFQGRALLVTNTLGCGALMAAGDGVRQSWEIRARPGQVFDPRRSASMFAVGCSMGPFLHYWYLSLDRLFPASGLRGFPNVLKKVLVDQLVASPLLGVWYFLGLGCLEGQTVGESCQELREKFWEFYKADWCVWPAAQFVNFLFVPPQFRVTYINGLTLGWDTYLSYLKYRSPVPLTPPGCVALDTRAD
Protein: V-type proton ATPase subunit S1 (V-ATPase subunit S1) (V-ATPase Ac45 subunit) (Q9TYW1)
Organism: Caenorhabditis elegans
Function: Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles (By similarity). In the germline, required for the trafficking of the receptor RME-2 to the oocyte cell membrane where it regulates the uptake of yolk proteins. Also, plays an essential role in osmoregulation in the embryo, probably by regulating the proper formation of the eggshell.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit
- Probable V-type proton ATPase subunit G
- V-type proton ATPase subunit C
- V-type proton ATPase subunit D
- V-type proton ATPase subunit B 1
- V-type proton ATPase catalytic subunit A
- Probable V-type proton ATPase subunit H 2
- V-type proton ATPase subunit e
- Probable V-type proton ATPase subunit F
Sequence:
MRVLFAVFSLIMACQAYDAVLFSNSREIGGTPAAKLVESATAEEPVVFIVNPDFTLGQFSVKANAYTSEPSADYLAKSVKNSNFHESQYFSHQIEATQAQWLSSADQYSAGSPIYIIYGEEWTSMEQLAEQLISKIDNSVGIITSTDAVAHEKSSRVKRVATDEFNSDSENSAAAEANGGFPFPLVIPPYNQTFYSVKPTNGHSCLFYLEGLTVVVEQKKEKVLYYANAYIPGSNFTWAYSETDVTCPNGTIGDFIFKIHLTLENDITGMQGTSKKAFTMKKGDKIDFDLTFTGDLFGYWALNKASASNLAISGYDPYKSASVDGSKVVNGSATQYTKLNSVAGWSLACGQSQAVFFPTNEQSVRIGVALMNTQIQLFNYQNPEKWVESAHFTLQTEDCTGTFSSGSWMGIVSALVLIAGLMFGYVMLQSVQTMDRFDDPKQRQIVINVRE
Protein: Nucleolysin TIAR (TIA-1-related protein) (P70318)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (By similarity). Shows a preference for uridine-rich RNAs (By similarity). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA. Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1. Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (By similarity). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (By similarity). May be involved in apoptosis (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16278295, ECO:0000269|PubMed:19861488}. Cytoplasm {ECO:0000269|PubMed:16278295, ECO:0000269|PubMed:19861488}. Cytoplasm, Stress granule {ECO:0000269|PubMed:19861488}. Cytolytic granule {ECO:0000250|UniProtKB:Q01085}. Note=Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (PubMed:16278295). Accumulates in cytoplasmic stress granules (SG) following cellular damage (By similarity). {ECO:0000250|UniProtKB:Q01085, ECO:0000269|PubMed:16278295}.
Interaction partners:
- Ras GTPase-activating protein-binding protein 1
- Cytotoxic granule associated RNA binding protein TIA1
- ELAV-like protein 1
- Ras GTPase-activating protein-binding protein 2
- Fragile X messenger ribonucleoprotein 1
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 4E
- TAR DNA-binding protein 43
- Far upstream element-binding protein 2
- Caprin-1
Sequence:
MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQETNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASFPTQ
Protein: Terpene synthase 2 (EC 4.2.3.-) (EC 4.2.3.161) (Q7KWU0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene (3S)-(+)-asterisca-2(9),6-diene. Is also able to convert geranyl diphosphate (GPP) into a mixture of monoterpenes including (Z)-beta-ocimene, allo-ocimene and linalool.
Interaction partners:
Sequence:
MDIKNLSLKDIKFPKSWETKPSKIEYMQFVYQEAIDMKVWRKDNEIDILTHHHVTDLSRFFWPNADFEGLVLGAELMVWFFAFDDLFDGGFIDDNENEQYRLVNRMNKVFLEGTIEDDSTGAERMGYYLRNKVRAICGEKRQSTFHRFNSSCVQWVDSIIPFIKLKRNQKSLDFNLYIHHRKFNIGAIPCFLVSEIILDPMSNIECFIWLDSRWIKMSEIICEIIALVNDCVSYEKEIKENGAPLNSLKFIQIEKNLNLQESFEYISNYLNELINQYIELETSFIKSYKPITSNYNSNFIAIVEHLHNMSFANVSWSTQTPRYLSQTQPFLELRRNKKIITKIYDLKNK
Protein: Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) (P39730)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Stimulates 20S pre-rRNA cleavage to mature 18S rRNA by PIN-domain endonuclease NOB1.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:9624054}.
Interaction partners:
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein uS15
- Eukaryotic translation initiation factor 5
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS3
- Eukaryotic translation initiation factor 1A
- Small ribosomal subunit protein RACK1
Sequence:
MAKKSKKNQQNYWDEEFEEDAAQNEEISATPTPNPESSAGADDTSREASASAEGAEAIEGDFMSTLKQSKKKQEKKVIEEKKDGKPILKSKKEKEKEKKEKEKQKKKEQAARKKAQQQAQKEKNKELNKQNVEKAAAEKAAAEKSQKSKGESDKPSASAKKPAKKVPAGLAALRRQLELKKQLEEQEKLEREEEERLEKEEEERLANEEKMKEEAKAAKKEKEKAKREKRKAEGKLLTRKQKEEKKLLERRRAALLSSGNVKVAGLAKKDGEENKPKKVVYSKKKKRTTQENASEAIKSDSKKDSEVVPDDELKESEDVLIDDWENLALGDDDEEGTNEETQESTASHENEDQNQGEEEEEGEEEEEEEEERAHVHEVAKSTPAATPAATPTPSSASPNKKDLRSPICCILGHVDTGKTKLLDKIRQTNVQGGEAGGITQQIGATYFPIDAIKAKTKVMAEYEKQTFDVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHGLEQQTIESIKLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQEEFQSRYSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAVTGEGVPDLLWLLLELTQKRMSKQLMYLSHVEATILEVKVVEGFGTTIDVILSNGYLREGDRIVLCGMNGPIVTNIRALLTPQPLRELRLKSEYVHHKEVKAALGVKIAANDLEKAVSGSRLLVVGPEDDEDELMDDVMDDLTGLLDSVDTTGKGVVVQASTLGSLEALLDFLKDMKIPVMSIGLGPVYKRDVMKASTMLEKAPEYAVMLCFDVKVDKEAEQYAEQEGIKIFNADVIYHLFDSFTAYQEKLLEERRKDFLDYAIFPCVLQTLQIINKRGPMIIGVDVLEGTLRVGTPICAVKTDPTTKERQTLILGKVISLEINHQPVQEVKKGQTAAGVAVRLEDPSGQQPIWGRHVDENDTLYSLVSRRSIDTLKDKAFRDQVARSDWLLLKKLKVVFGIE