wanglab/gogpt-training-data huggingface dataset:
Protein: Large ribosomal subunit protein eL19 (60S ribosomal protein L19) (P84100)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P84098}.
Interaction partners:
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL27
Sequence:
MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK
Protein: Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1) (P22415)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
Subcellular location: Nucleus.
Interaction partners:
- Upstream stimulatory factor 2
- General transcription factor II-I
- Histone acetyltransferase p300
- Transcription factor Sp1
- Fos-related antigen 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
- Transcription initiation factor TFIID subunit 7
- Mediator of RNA polymerase II transcription subunit 1
- Estrogen receptor
- DNA-binding protein RFX5
Sequence:
MKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPDPNVKYVFRTENGGQVMYRVIQVSEGQLDGQTEGTGAISGYPATQSMTQAVIQGAFTSDDAVDTEGTAAETHYTYFPSTAVGDGAGGTTSGSTAAVVTTQGSEALLGQATPPGTGQFFVMMSPQEVLQGGSQRSIAPRTHPYSPKSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKACDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHGLEVVIKNDSN
Protein: F-box DNA helicase 1 (EC 5.6.2.4) (DNA 3'-5' helicase 1) (F-box only protein 18) (F1ND48)
Organism: Gallus gallus (Chicken)
Function: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8NFZ0}. Chromosome {ECO:0000250|UniProtKB:Q8NFZ0}. Note=Accumulates at sites of DNA damage or replication stress. Localizes to the nucleoplasm in absence of DNA damage. {ECO:0000250|UniProtKB:Q8NFZ0}.
Interaction partners:
- Fanconi anemia group M protein
- S-phase kinase-associated protein 1
- DNA repair protein RAD51 homolog 1
- Uncharacterized protein.
- Uncharacterized protein.
- Zinc finger RANBP2-type containing 3.
- DNA repair protein RAD52 homolog
- Proliferating cell nuclear antigen
- DNA repair protein
- DNA repair and recombination protein RAD54-like
Sequence:
MHLTADDCEALSRSTEGLSSLTQPLNQRRSRGDVNRGLQPTHRTRTQPGAQGRQKNIMDYFKVSQRQQAVAGRTKDISIKEEVLDPFFAEDDESSISSVMETSGDSSSFLENEYMGNSRKRPLSSTAPGRLQIENDLWGEPEKKAVVVHPEHSQIKQELDDEIEIEPVPDSHYGLLGTRNWEVPQGSIEDLPDEVLRSIFAFLPVTDLYQSLSLVCRRWRIIVGDPWFIPWKKLYHQYLVKEDMALRRVEQVLQDFAITGQHKECILGLIRCVSTIPTSRNVDPSAVLQCLKGHHLFSRAEVCITNKLPHLQSKTGPEYMWAIITAMVLFSDGVRDIQRLMACLQRPCSSLSIVDVTETLYCIATLLYAMREKNINITNRIHYNIFYCLYLMENASVTAPQVVEEETPSSRCRQDFWSSSLSEVKLTHEQQRILNHKIERGQIVKIMAFAGTGKTSTLVKYAEKFADLSFLYVTFNKAVAERGRLVFPRNVTCKTFHSLAFGSVGKLYKEKGKLNFSKLSAYSVSFLIQNREGQSIFIRGKTVSQTLENFFASSDEEICEEHTPVWFKNTHGERKLVTPEEKRINVEEAKEIWRNMKKLDGDVERKYKITCDGYLKLWQLSKPQLSGYDAIFVDEAQDCTPAIVDIVLSQTCGVILVGDPHQQIYSFRGAVNTLYTVPHTHIYYLTQSFRFGPEIAYVGATILDVCKGIRNKTLVGGNQEGDVRGSMEGKITMLSRSNFTVFEDAAKLAGRERQIKIHIIGGLVRFGLSKIYDIWKLSQPADEREKANLVINDSFIKRWEENEGFIGLKDYATRVDDKELEMKIRIVEKFKERIPELVQKIESSHVLQEAMADYLIGTVHQAKGLEFDTVLIADDFVDVPCARDNNQRRPQFIIGMCPEDEWNLLYVAVTRAKKCLLMSQSLEHLLALAGEHFLRVELMGEAVKTGVACSTQQCTQTLQSGIRLVVKKLPLIHSNGSRDMGGYLCYSCVQKRFGSMTPLAFLPALQEEPIVL
Protein: Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (UDP-MurNAc-pentapeptide phosphotransferase) (P0A6W3)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00038, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00038, ECO:0000269|PubMed:15919996}.
Interaction partners:
- UDP-N-acetylmuramoylalanine--D-glutamate ligase
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- Probable peptidoglycan glycosyltransferase FtsW
- UDP-N-acetylmuramate--L-alanine ligase
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
- Peptidoglycan D,D-transpeptidase FtsI
- D-alanine--D-alanine ligase B
- Undecaprenyl-diphosphatase
- Putative undecaprenyl-diphosphatase YbjG
Sequence:
MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
Protein: L-arabinose 1-dehydrogenase (NAD(P)(+)) (L-AraDH) (EC 1.1.1.376) (D4GP33)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: L-AraDH initiates the degradation of L-arabinose. Catalyzes the NAD(P)(+)-dependent conversion of L-arabinose to L-arabino-gamma-lactone. It is highly specific for L-arabinose as substrate and can use both NADP(+) and NAD(+) as electron acceptor, with a slight preference for NADP(+).
Interaction partners:
Sequence:
MARIAVTGAAGNVGRVTVEALASDHDVTPITHREREGLDSVILDVRDEDALTEAFEGHDIVVHLAANPNPDAAWDSVYEVNIGGTYNVYEAALAADIDRLVFASTNHVHQMYNIADATRPETLAADAEAVGVSDPPRPDSYYGVSKVFGEALGNYYADRHGLEVLNLRIGWLLTADEVREKMDEEESVARYVRAMWLSPGDCEQGMRRAVEASLPDSPLAVNLISANDDRYLSLTETMRAIGYRPRDNSATVVE
Protein: Transcription factor MYB94 (Myb-related protein 94) (AtMYB94) (Q9SN78)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator involved in the activation of cuticular wax biosynthesis under drought stress. Binds directly to the promoters of genes involved in cuticular wax biosynthesis. Transactivates WSD1, KCS2/DAISY, CER1, CER2, FAR3 and ECR genes. Functions together with MYB96 in the activation of cuticular wax biosynthesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:25305760}.
Interaction partners:
- Protein ECERIFERUM 2
- Ethylene-responsive transcription factor WIN1
- 3-ketoacyl-CoA synthase 6
- Fatty acyl-CoA reductase 3
- Very-long-chain aldehyde decarbonylase CER1
- 3-ketoacyl-CoA synthase 2
- Wax ester synthase/diacylglycerol acyltransferase 1
- 3-ketoacyl-CoA synthase 1
- Very-long-chain 3-oxoacyl-CoA reductase 1
- Very-long-chain aldehyde decarbonylase CER3
Sequence:
MGRPPCCDKIGVKKGPWTPEEDIILVSYIQEHGPGNWRSVPTHTGLRRCSKSCRLRWTNYLRPGIKRGNFTEHEEKMILHLQALLGNRWAAIASYLPERTDNDIKNYWNTHLKKKLKKMNDSCDSTINNGLDNKDFSISNKNTTSHQSSNSSKGQWERRLQTDINMAKQALCDALSIDKPQNPTNFSIPDLGYGPSSSSSSTTTTTTTTRNTNPYPSGVYASSAENIARLLQNFMKDTPKTSVPLPVAATEMAITTAASSPSTTEGDGEGIDHSLFSFNSIDEAEEKPKLIDHDINGLITQGSLSLFEKWLFDEQSHDMIINNMSLEGQEVLF
Protein: Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (40S ribosomal protein S4) (Protein LLRep3) (P25444)
Organism: Mus musculus (Mouse)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P15880}. Note=Probably localized to nucleolus and cytoplasm in complex with ZNF277. {ECO:0000250|UniProtKB:P15880}.
Interaction partners:
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL33
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL43
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein eL13
Sequence:
MADDAGAAGGPGGPGGPGLGGRGGFRGGFGSGLRGRGRGRGRGRGRGRGARGGKAEDKEWIPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAPAVATT
Protein: Membrane-anchored lipid-binding protein LAM5 (Lipid transfer at contact site protein 2) (Lipid transfer protein anchored at membrane contact sites 1) (P43560)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in sterol transfer between intracellular membranes.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26001273}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to intracellular puncta representing endoplasmic reticulum (ER)-mitochondrion membrane contact sites, nucleus-vacuole junctions (NVJ) and other non-NVJ ER-vacuole contact sites. {ECO:0000269|PubMed:26001273}.
Interaction partners:
- Membrane-anchored lipid-binding protein SIP3
- Membrane-anchored lipid-binding protein LAM1
- Calcium-channel protein CCH1
- Putative uncharacterized protein YDL034W
- Coatomer subunit alpha
Sequence:
MSDVDNWEPVSDNEDSTDSVKQLGPPFEHASNNDNAGDTEAESLQEVPLNTETNDVRKNLVVITNQSAADEHPTEIKHDQSRTSSTSSFFSGMISSFKSNVPSPVSRSTTPTSPVSQPSIISHRREPSMGSKRRSSRRISNATIAEIGSPLQQVEKPDEVKTRLTPSQMKEDNYDHRRFVEERYMDTPYHYASEQRNKDFHETFKSVPKDDRLLDDFNCGLNRELLYQGKLYITETHLCFNSNVLGWIAKVLIAFEDVTFMEKTSAAGLFPSAISIETKMGKTLFNGFISRDAAFGLMKEVWSRTLLQKDMASENINTKAEKSGNGKEIDDAINSIDEENNDKDANDNDTNENDDENISTNETTPNSTSSSPDKEKEKAYKLRADSSYQYDGPIYHHSTSFPAEPMANNEFVLKELPFDCAPGILFEIMFNSEQNEFLLDFLRGQEGSQITTIPNFTSIDGSSMTLKREYSYEKALHFPAGPKSTTCYVAEVIKRKDPDTYYEVISSIRTPNVPSGGSFSTKTRYLIRWNDEITCLLRVSFWVEWTGSSWIKGMVENGCKNGQLEAAQLMERILSKFIKNNVEECQITISKEEEEQDDKEVKNKLKEVDLEQPREAVVTAPAIAEQQGLKVTMETWLFLYLIVVVLLLFNLFYIRSIAVSLHQLVKLQLVELKL
Protein: Equilibrative nucleotide transporter 6 (AtENT6) (Nucleoside transporter ENT6) (Q944N8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Nucleoside transporter that can mediate uptake of adenosine, uridine, guanosine or cytidine when expressed in a heterologous system (yeast).
Subcellular location: Cell membrane {ECO:0000305|PubMed:15228386}; Multi-pass membrane protein {ECO:0000305|PubMed:15228386}. Note=Plasma membrane.
Interaction partners:
- Putative defensin-like protein 101
- Putative defensin-like protein 135
- Purine permease 2
- Putative defensin-like protein 62
- Defensin-like protein 90
- Nucleoside hydrolase 3
- Purine permease 14
- Putative F-box protein At4g05475
- Purine permease 1
- Putative purine permease 15
Sequence:
MADIYEHQVPEKLRGKYQAMIVYCILGFGSLISWNSMLTTADYYYKVFPDYHPSRVLTLVYQPFAFGAIVILAYHESKTSTRKRNLIGYILYTISTFLLIVLDLATKGRGGFGPYTGLCAVVAAFGLADATVQGGMFGDLSLMCPELVQSYMGGMAVAGALTSALRLITKAAFEKSNNGLRKGAMMFLAISTCIELLSVMLYAYVLPKLPIVMYYRRKAASQGSKTVSADLAAAGIQNQSDLSDDDSKNQRLSKKELLFQNIDHAVNLFLIYVCTLSIFPGFLYENTGQHGLGAWYALVLVAMYNCWDLVGRYTPLVKWLNIENRKLITIAVLSRYLLIPAFYFTAKYGDQGWMIMLVSVLGLTNGHLTVCIMTIAPKGYKGPEQNALGNLLVIFLLGGIFAGVALDWLWLIGKKNAF
Protein: Cytochrome P450 1A1 (EC 1.14.14.1) (CYP1A2) (CYPIA1) (Q92110)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
Sequence:
MVLMILPIIGSVSVSEGLVAIVTLCLVYMLMKYKHTEIPEGLKRLPGPKPLPIIGNVLEVYNNPHLSLTAMSERYGSVFQIQIGMRPVVVLSGNETVRQALIKQGEDFAGRPDLYSFKFINDGKSLAFSTDKAGVWRARRKLAMSALRSFATLEGTTPEYSCALEEHVCKEGEYLVKQLTSVMDVSGSFDPFRHIVVSVANVICGMCFGRRYSHDDQELLGLVNMSDEFGQVVGSGNPADFIPILRYLPNRTMKRFMDINDRFNNFVQKIVSEHYESYDKDNIRDITDSLIDHCEDRKLDENANIQVSDEKIVGIVNDLFGAGFDTISTALSWAVVYLVAYPEIQERLHQELKEKVGMIRTPRLSDKINLPLLEAFILEIFRHSSFLPFTIPHCTIKDTSLNGYFIPKDTCVFINQWQVNHDPELWKEPSSFNPDRFLSADGTELNKLEGEKVLVFGMDKRRCIGEAIGRNEVYLFLAILLQRLRFQEKPGHPLDMTPEYGLTMKHKRCQLKASMRPWGQEE
Protein: Dynein light chain (Q4FKD8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU365010}.
Interaction partners:
- Cytoplasmic dynein 2 light intermediate chain 1
- Dynein light chain, putative
- Dynein light chain, putative
- Uncharacterized protein
- Dynein light chain roadblock
- Dynein light chain 2B, cytoplasmic, putative
- Dynein light chain 2B, cytoplasmic, putative
- Dynein light chain roadblock
- Dynein light chain roadblock
- Dynein heavy chain, cytosolic, putative
Sequence:
MSTDRKAIIKNADMPEDMQSDAVEVALQALEKFNIEKDIAAYIKKEFDKKYQPTWHCIVGRNFGSYVTHETHSFLYFYFGQVAILLFKSG
Protein: Protein phosphatase 2 regulatory subunit B''alpha (Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1) (A0A803JG39)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Interaction partners:
Sequence:
MAAPYKVIVSKVTCYNSVVLDKRLENVIHYCHGICQVHRLGVQCRVAHHSVCSELVKAPGGSPSHTKDVTHKIIAGEGVVGGEESSHLNSRNKKPSATQSTGSLKDITGEAINLASGKAKEFSFEKLRNASNQHVNLRKGRKVRPDSFNRKSTDYDFIYGQFGNNENCPPNDVSQGQGVEEKAMVSNSASWEQNLNNMAALYLQGLADENLINQILKKHNLDGAGSGEDIKMCLDILLKCSEDLKKCTNIIKQCIRNRSIGSNNTSEGKGEDHFPNPEIIYMNVMARLSSYLKKLPFELEHSPRGRGEPSDLAELVSSIRSLQQQPFSPIYGHEQPPKYEDVVQMPPSVKTISPSATEYNRELTPQIPNINNATTVKNVSPVAPPLPAKTWQRGTQQNKGSSVKSNFAPFQQMSHGTNQVFSNTGERLPRPSVENLYIEEDSDLERSVNHQKCAAGLSVSESVEPKLSRKSIHSHRPIDNSMTVTKNTSFSSNGTYHTGSHSYNTHASNTGKSADHEEIDKLLLDLEKFSKKIETTLNNPPSTTPSKTQSRFPVLHKEPNSQLPSASGTIASEHKLEDDEGNLLLRILGSIEDFAQELVDWRSGKGTLSKQKEVMKILQETLVTPPSSPGIQLQNQSKDLGPTLSIQQTPEIIKIQSKQEKKPNTPPPVPLTPTASPRPATPPLPSNKATAPVSINIPRFYFPKGLPNPGSDYEDSIKKTEAAFSSMEEEKADIYEMGKIAKVCGCPLYWKAALFNAAGGERTGFVSVHSFIAMWRKLIQNCHDDAPKFISLLAKPGCDYLEQEDFIPLLQDIVDTHPGLTFLKEAPEFHSRYITTVIQRIFYTVNRSWSGRITLTELRRSNFLQTLALLEEEDDINQVTDYFSYEHFYVIYCKFWELDTDHDLYIDQKDLGRYNDHASSKRIIERIFSGAVTRGNAVQREGRMSYAEFVWFLISEEDKKNPTSIEYWFRCMDLDGDGVLSMYELEYFYEEQCEKMEAMGIEPLPFQDLLCQLLDLVKPEAEGQITLRDLKRCKMAHIFYDTCFNLEKYLDHEQRDPFAVQKDVESENPEPSDWDRYASEEYEILVAEESATEQLQEESFDDDYEGEEIISPPEISNKMDKLVISDLTA
Protein: Small ribosomal subunit protein mS29 (37S ribosomal protein S23, mitochondrial) (DAP-3) (Q01163)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS29 binds GTP and is probably an active GTPase. GTP hydrolysis may be linked to subunit association. mS29 also has an extraribosomal function, being required for maintenance of mitochondrial DNA.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11278769, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein mS33
- Ribosome assembly protein RSM22
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein mS42
- Small ribosomal subunit protein bS6m
Sequence:
MLRMSTSRFIGQRLFTTARSLQAAKPAPKGKTQGFSKKSSSVSSYSSAKRVTPGSLYKNWTNTTHTAQLQQTAVPLALPIFNFDDISKTLNKVVSYSNKQYKSLHHLGSFKKSQFNELFQKPVCLVREDATNSFLKKLVSHPVKKFIITGEPGVGKTVLLSQAHAYAVDSKQIIINISYPELFLNGRNDFSYDDDLKLFIQPMYLKKLIRKILKANDPALLKSIELSKDYKFSNANPKNASVKPFVTLNKTKNTVLDLLSVMTHPHNRGKLMKAIIDELSVQSKVPIMFTVDNFSKVLTTAYSAYRNTENKQIYSLDLQMGKLMMDIISGETKFANGESSTILAISGVDRTNKTLPVALGKIPVDPYVTRYHYEPKFVELLQKGNVTEFEVPKLNKQEVNELIDYYKQSNVLLDKDITGKKWENLIDEKYFLSGNGNPRELLKSLVLSHR
Protein: Phospholipase D1 (PLD 1) (EC 3.1.4.4) (Choline phosphatase 1) (Meiosis-specific sporulation-specific protein 14) (Phosphatidylcholine-hydrolyzing phospholipase D1) (P36126)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events. PLD activity is induced under sporulation conditions and seems to be necessary to complete the meiotic cycle, but not for vegetative cell growth.
Interaction partners:
- Phosphatidate cytidylyltransferase
- SEC14 cytosolic factor
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
- Cholinephosphotransferase 1
- Phosphatidylserine decarboxylase proenzyme 2
- Phosphatidic acid phosphohydrolase 1
- CTP-dependent diacylglycerol kinase 1
- Lipid phosphate phosphatase 1
- Diacylglycerol pyrophosphate phosphatase 1
- Choline/ethanolaminephosphotransferase 1
Sequence:
MSNVSTASGTHFAPPQADRSVTEEVDRVNSRPDELENQEVLRQLPENGNLTSSLQREKRRTPNGKEAERKHALPKSFVDRNLSDVSPNHSLDHIMHSNEHDPRRGSDEENMHRLYNNLHSSNNNVHSKRNSKREEERAPQRRSSSVAYTQQQFNGWKKEFGHAFKKISAIGRLKSSVNSPTPAGSGHRHNQHQHQQVNEEDLYTQRLASDLLDSLLAGCPASLFASTQFLRDEHGKRRAPLLLAKLDVRVSPLKNDNNILDITNSNHNHRGNNNNNTGENSDRRPSIPRSSSIISISSNVAEFMYSRNENSLFRIHLEYGIDEDRLKWSIIRSYKDIKSLHHKLKIVAFQQLTISKLYSDNNRYHSLQLPHFPHYKEMVKERNVMEKKAENKPSSAASAPHTSENNNNDNGSNITSLETLSSSEISEFNIDNVKMKHLQDLIDEPDDFSQPIHLRLERYLRLLNIALCLRPHANRLFEFYELSPLGNLLSRESGFQGKQGYLVIRSTAKAQGWRVSHFGKHAFKDMIDRHTTKWFLVRNSYLTYVSDLSSTTPLDVFLIDWKFKVRFSGNKNNILDNENEINWIIHDPNLEINDELEEFGIENDANNILDKNGKSKTHQKKSNISSKLLLLTLENSERKLKIICKSESSLKQWMSSIIKMSTSTPWSKPNRFGSFAPVRTNSFCKFLVDGRDYFWSLSEALLMAKDVIYIHDWWLSPELYLRRPVKGNQGFRIDRMLKSCAEKGIKIFIVIYRNVGNIVGTDSLWTKHSMLNLHPNIHIIRSPNQWLQNTYFWAHHEKFVVIDETFAFIGGTDLCYGRYDTFEHVLRDDAESLLDQNFPGKDYSNARIADFHDLDKPFESMYDRKVIPRMPWHDVQMMTLGEPARDLARHFVQRWNYLLRAKRPSRLTPLLTPPSDLTAEELKSLPMFEILREKSTCETQILRSAGNWSLGLKETECSIQNAYLKLIEQSEHFIYIENQFFITSTVWNGTCVLNKIGDALVDRIVKANQEKKPWKAFILIPLMPGFDSPVDTAEASSLRLIMQFQYQSISRGEHSTFSKLKKLNIDPAQYIQFFSLRKWSTFAPNERLITEQLYVHAKILIADDRRCIIGSANINERSQLGNRDSEVAILIRDTDLIKTKMNGDDYYAGKFPWELRQRLMREHLGCDVDLVEFVEKKFERFEKFAAKNYEKLHTLSKEGDSGNNWSDREMIDSAMIELGYREIFGCKFSPQWKSGHGNSVDDGSTQCGINEKEVGREDENVYEKFFNSVDYGKSSRKRTPLPKHNFASLGLTFNHRAGIENVGIRDHKVLSTDPRLRKNDEHKKEVDGYGPDCWKKESNKKFKADATEQLKEWALNSLASKVLDDKEMIKSEIPEGFSNYLPNEKDLEMYLTDKTVTNRNKWSMLKRICYLQYLSHKLDERKTQRLKKIKDMRRHLSSSTESTRNGSNSLPLNEKSNEGESTNVDQDIEGDEYHRLHEDILKNQELDDGSLDDLLSQIIPKITNFNSGEIDDAKKEELLKLNFIDPYSFEDPLISSFSEGLWFTIALRNTLLYKLVFHCQPDNAVQNWKEYGEFTELEQEFQINQEKLIDLEAENINSTTTNVVDKDREKEKMRKAAELRMKLSGSLLYGFNQKVFDKHTAQRILERIHGHLVIFPTEWLAKEVESRNWIFNSDRLSPMEIYN
Protein: Copalyl diphosphate synthase 1, chloroplastic (IrCPS1) (EC 5.5.1.12) (Terpene synthase 3) (IrTPS3) (A0A1X9IRQ7)
Organism: Isodon rubescens (Rabdosia rubescens)
Function: Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities. Catalyzes the conversion of (2E,6E,10E)-geranylgeranyl diphosphate (GGPP) to (+)-copalyl diphosphate ((+)-CPP).
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MASLSTMHLINHSPASRRRIMSAAAAAAAKLHLPECFTITKSAWMNNTENLTLNYQLNHKKISKVAGINRVATVDAPQVHDQDDSTENQGHDAVNNIEDPIEYIRTLLRTTGDGRISVSPYDTAWVALIKDLNGRDAPEFPSSLEWIVRNQLDDGSWGDDKFFCVYDRLVNTIACVVALRSWNVHDDKLKRGVTYIKENVEKLRDGNVEHMTCGFEVVFTALLQRAKCLGIEDLPYDSPLIQEIYHSRQQKLNRIPMEMMHKVPTSLLFSLEGLENLEWERLLKLQSADGSFLTSPSSTAFAFMQTKDEKCYQFIKNTVETFNGGAPHTYPVDVFGRLWAVDRLQRLGISRFFESEIAECLAHIHKFWTEKGVFSGRESEFCDIDDTSMGIRLLRMHGYDVDPNVLRNFKKDDNFSCYGGQMIESPSPIYNLYRASQLRFPGEEILEDANKFAYNFLQEKLANNQILDKWVISKHLPDEIKLGMEMPWYATLPRVEARYYLQYYAGSGDVWIGKTLYRMPEISNDTYHELAKTDFKRCQAQHQFEWIYMQEWYESCNVEEFGISRKELLLAYFLATASIFELEKTKERIAWAKSQIISKMITSFFNNHNTSSEEKLAFLTDFRNSNGLNNTNMVLATLTQFLEGFNRYTSHQLKNAWGEWLAKLQQGEGDGAADAELLTNTLNICAGHIAFREEILSHNEYTTLSNLTSKICQQLSQIQNEKKMEIEGQMTAETSIKNKELEQDMQTLVKLVLGKSSGINRNIKKTFLAVAKTYYYRAYHDAQTIDTHMFKVLFEPVV
Protein: Cadherin 9 (D3ZFQ5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
Interaction partners:
- Cadherin-13
Sequence:
MRTYHFLQLIVWTWIFQMVDNSPLQGKDNIHLRKRIVNLKKDDGKMLHRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGNLFVIDENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSLESAPLGTHLGRIKANDPDTGENAELEYSISEGEGSDMFDVITDKDTQEGIITVKQNLDFEKKMLYTLRVDASNTHPDPRFLHLGPFKDSAMVKISVEDVDEPPVFSKLSYLMEVDEDVKEGSIIGQVTAYDPDAMNNIINIHSENGSIFTLKPLDRESSPWHNITVTATELNNPKQSSQIAVFIRILDINDHSGQVTLIQTISVMDKMILPEDTSSFLSQCQNFPLNPNFTIVDNKDGYSRNKMNTLLLPVLIFDNDYPIQSSTGTLTISCNAEALMLAAGLSTGALIAILLCVVILLTLIGLLAALKRQRKKEPLIISKDDVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIRRTVPLWENIDVQDFIHRRLKENDSDPSAPPYDSLATYAYEGNDSVANSLSSLESLTADCNQDYDYLSDWGPRFKKLAEMYGGDDSDRD
Protein: RNF220 protein (Q9BWG1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFTMLCINGTTPRPLPVPSPFGCMIFFFFKNPWKQCLLQGWLGARPIHLLGYLPLSLLWCPFPLPCARCSVVYISSPRHGAHAPRDMILSLVLAHGALYKELGGRGRKWEPS