wanglab/gogpt-training-data huggingface dataset:
Protein: Tapetal oleosin GRP-17 (T-oleosin GRP-17) (Glycine rich protein 17) (AtGRP-17) (Glycine rich protein 7) (AtGRP-7) (Oleopollenin GRP-17) (Q9LY09)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lipid-binding oleosin pollen coat protein required to mediate pollen recognition by stigma cells and subsequent pollen hydration. Involved in anther tapetum development, especially for the physiology of tapetosomes. Also implicated in the formation of pollen coat.
Subcellular location: Secreted, extracellular space, extracellular matrix, pollen coat {ECO:0000269|PubMed:10655594, ECO:0000269|PubMed:11431566, ECO:0000269|PubMed:26305561}. Lipid droplet {ECO:0000250|UniProtKB:C3S7F0}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Surface of oil bodies (By similarity). Oleosins exist at a monolayer lipid/water interface (By similarity). Associated with discrete organelles (e.g. granules of 1-5 um in diameter) within the anther tapetum called tapetosomes and with a network of structures previously described as fibrils or 'strings of beads' (PubMed:23602096, PubMed:26305561). {ECO:0000250|UniProtKB:C3S7F0, ECO:0000269|PubMed:23602096, ECO:0000269|PubMed:26305561}.
Interaction partners:
- GDSL esterase/lipase EXL4
- Probable peroxygenase 7
- GDSL esterase/lipase EXL5
- GDSL esterase/lipase EXL6
- Glycine-rich domain-containing protein 2
- Probable inactive peroxygenase-like protein
- GDSL esterase/lipase 4
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- SIT4 phosphatase-associated family protein
- Cysteine-rich repeat secretory protein 41
Sequence:
MSEELSQKPSSAQSLSLREGRNRFPFLSLSQREGRFFPSLSLSERDGRKFSFLSMFSFLMPLLEVIKIIIASVASVIFVGFACVTLAGSAAALVVSTPVFIIFSPVLVPATIATVVLATGFTAGGSFGATALGLIMWLVKRRMGVKPKDNPPPAGLPPNSGAGAGGAQSLIKKSKAKSKGGLKAWCKKMLKSKFGGKKGKSGGGKSKFGGKGGKSEGEEGMSSGDEGMSGSEGGMSGGEGGKSKSGKGKLKAKLEKKKGMSGGSESEEGMSGSEGGMSGGGGSKSKSKKSKLKAKLGKKKGMSGGMSGSEEGMSGSEGGMSSGGGSKSKSKKSKLKAKLGKKKSMSGGMSGSEEGMSGSEGGMSGGGGGKSKSRKSKLKANLGKKKCMSGGMSGSEGGMSRSEGGISGGGMSGGSGSKHKIGGGKHGGLGGKFGKKRGMSGSGGGMSGSEGGVSGSEGSMSGGGMSGGSGSKHKIGGGKHGGLRGKFGKKRGMSGSEGGMSGSEGGMSESGMSGSGGGKHKIGGGKHKFGGGKHGGGGGHMAE
Protein: Hsc70-interacting protein (Q8I3J0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MIDEKKVEDLKQFVTLCQENPSILLKPELGFFKKFIESFGGKVSKDKEFFEKSASDESTEEKSDEEEVEEDENDKDDVEEEEEDDVQEDEDEEEDDDERCKDFMVEETIECPPLAPIVDEDLSDEVLEEISNLKIEAAELVQDNKFEEALEKYNKIIAFGKPSAMIYTKRASVLLSLKRPKACIRDCTEALNLNIDSANAYKVRAKAYRHLGKWECAHADIEQGQKIDYDEDLWEMQKLIEEKYKKIYEKRRFKINREEEKKRKKREKELKKRLAARKAAEKAYKANNKRENYDSDSSDSSYSEPDFSGDFPGGMPGGMPGGMPGGMPGGFPGGFPGGMPGGMPGGFPGGMPGGMPGGMPGGMPGGMPGGMPSGMPGGMPSGMPGGMPGGMPGGMPDLNSPEMKELFNNPQFFQMMQNMMSNPQLISKYANDPKYKNLFENLKNSDFGNMMGKENGKN
Protein: Sodium channel protein type 11 subunit alpha (NaN) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Q9R053)
Organism: Mus musculus (Mouse)
Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:24036948}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sodium channel regulatory subunit beta-1
- Sodium channel regulatory subunit beta-4
- Sodium channel protein type 1 subunit alpha
- Sodium channel regulatory subunit beta-2
- Class E basic helix-loop-helix protein 23
- Sodium channel protein type 9 subunit alpha
- Sodium channel protein type 8 subunit alpha
- Sodium channel regulatory subunit beta-3
- Sodium channel protein type 10 subunit alpha
- Sodium channel protein type 5 subunit alpha
Sequence:
MEERYYPVIFPDERNFRPFTFDSLAAIEKRITIQKEKKKSKDKAATEPQPRPQLDLKASRKLPKLYGDVPPDLIAKPLEDLDPFYKDHKTFMVLNKKRTIYRFSAKRALFILGPFNPIRSFMIRISVHSVFSMFIICTVIINCMFMANNSSVDSRPSSNIPEYVFIGIYVLEAVIKILARGFIVDEFSYLRDPWNWLDFIVIGTAIAPCFLGNKVNNLSTLRTFRVLRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILSQKCIKDDCGPNAFSNKDCFVKENDSEDFIMCGNWLGRRSCPDGSTCNKTTFNPDYNYTNFDSFGWSFLAMFRVMTQDSWEKLYRQILRTSGIYFVFFFVVVIFLGSFYLLNLTLAVVTMAYEEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRTSLNSLQASSFSPKKRKFFGSKTRKSFFMRGSKTARASASDSEDDASKNPQLLEQTKRLSQNLPVELFDEHVDPLHRQRALSAVSILTITMQEQEKSQEPCFPCGKNLASKYLVWECSPPWLCIKKVLQTIMTDPFTELAITICIIVNTVFLAMEHHNMDNSLKDILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNIFDSIVALVSLADVLFHKLSKNLSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLTIVVFIFSVVGMRLFGAKFNKTCSTSPESLRRWHMGDFYHSFLVVFRILCGEWIENMWECMQEMEGSPLCVIVFVLIMVVGKLVVLNLFIALLLNSFSNEEKDGNPEGETRKTKVQLALDRFSRAFYFMARALQNFCCKRCRRQNSPKPNEATESFAGESRDTATLDTRSWKEYDSEMTLYTGQAGAPLAPLAKEEDDMECCGECDASPTSQPSEEAQACDLPLKTKRLPSPDDHGVEMEVFSEEDPNLTIQSARKKSDAASMLSECSTIDLNDIFRNLQKTVSPQKQPDRCFPKGLSCIFLCCKTIKKKSPWVLWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVNLPSRPQVEKLLKCTDNIFTFIFLLEMILKWVAFGFRKYFTSAWCWLDFLIVVVSGLSLTNLPNLKSFRNLRALRPLRALSQFEGMKVVVNALMSAIPAILNVLLVCLIFWLIFCILGVNFFSGKFGRCINGTDINKYFNASNVPNQSQCLVSNYTWKVPNVNFDNVGNAYLALLQVATYKGWLDIMNAAVDSRGKDEQPAFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGTKKPQKPIPRPLNKCQAFVFDLVTSQVFDVIILGLIVTNMIIMMAESEGQPNEVKKIFDILNIVFVVIFTVECLIKVFALRQHYFTNGWNLFDCVVVVLSIISTLVSGLENSNVFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMNWFSKVKRGSGIDDIFNFDTFSGSMLCLFQITTSAGWDALLNPMLESKASCNSSSQESCQQPQIAIVYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFEIFYEIWEKFDPEATQFIQYSSLSDFADALPEPLRVAKPNRFQFLMMDLPMVMGDRLHCMDVLFAFTTRVLGNSSGLDTMKAMMEEKFMEANPFKKLYEPIVTTTKRKEEEECAAVIQRAYRRHMEKMIKLKLKGRSSSSLQVFCNGDLSSLDVPKIKVHCD
Protein: Transmembrane protein 14C (Q9CQN6)
Organism: Mus musculus (Mouse)
Function: Required for normal heme biosynthesis.
Subcellular location: Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Iron-sulfur clusters transporter ABCB7, mitochondrial
- ATP-binding cassette sub-family B member 10, mitochondrial
- Ferrochelatase, mitochondrial
- Mitochondrial glutathione transporter SLC25A39
- Iron-sulfur cluster assembly factor IBA57, mitochondrial
Sequence:
MQKDSGPLMPLHYFGFGYAALVATGGIIGYAKAGSVPSLAAGLFFGGLAGLGAYQLSQDPRNVWVFLATSGTLAGIMGMRFYNSGKFMPAGLIAGASLLMVAKVGISLLSSPHP
Protein: Fanconi anemia group B protein homolog (Protein FACB) (Q5XJY6)
Organism: Mus musculus (Mouse)
Function: DNA repair protein required for FANCD2 ubiquitination.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Fanconi anemia group F protein
- Fanconi anemia group M protein homolog
- E3 ubiquitin-protein ligase FANCL
- Fanconi anemia core complex-associated protein 24
- Fanconi anemia core complex-associated protein 100
- Fanconi anemia, complementation group E
- Fanconi anemia group G protein homolog
- Fanconi anemia group C protein homolog
- Fanconi anemia group A protein homolog
- Fanconi anemia group I protein homolog
Sequence:
MSKQSSCAIMGKSLSFSLSRGERADLEMPTDPLVLGVKRMMFDRETSTFLLISTVFLNINEKDSHLKILCCNCVSDLRTRINLPCVLIQCRKYNSEAFKYCILLLHNLNRVERLLSFELNHALDENTKIFDGPIVFWQYLNQFFYISSAIGKVTTISLMLSSIEWIGEIENFGLGFLGLAEPSEDKCTQKLSESDYEFSNSSLCAYALKSQEMLSNGYLIPLAYSTMVTHVHVWAAEMVDHQLRTSLIALTRKNQLILFQNGIPVRACQLPFPGPRSVQILDAGKRNRFFIVSFPSKACAVSEKKFKVVAKWEQLSLVLVNDFAGVGTEQVLVVFEDSLDADQLTSFTVTDFVKIWYSTKPLDCCEDPLAEEEHENYYLVLPALEGQLDNSFIFLNKIQQHISFKDKFIAKSWKALLNAVYGKGDSLPSDEMVKLDQDGLVPFCDEGEDSVPTPEENLPDNFPEPEHIVEQTWCHVLDDDLVVGAKVTSLKESNEMTLSLIMNQGNRSSFHLMKCHSQVWLLKHMKCERIQECTEIYLYKKLRNCGALFSWEQRTASEGILTIYCRSQGVLFQCLDHLIKVLPEICSFKYLKVENEDFLVDHLSSTLEAELVTFCSVSTSAFEYVRGGYNCRIRRTDNRAMTFLGRRAKIRQSKRKVQRERILKHLNMTVNGSSYAEMTLALAEIQLKSDLIVKTLANFVIAL
Protein: Nucleotide-binding oligomerization domain containing 1 (D4ADT7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004187}. Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
Interaction partners:
- Receptor-interacting serine/threonine-protein kinase 2
- Autophagy-related protein 16-1
- Protein SGT1 homolog
- Nucleotide-binding oligomerization domain-containing protein 2
- NLR family CARD domain-containing protein 4
- Caspase-1
- Apoptosis-associated speck-like protein containing a CARD
- NLR family, apoptosis inhibitory protein 6
- Pyrin
- Toll-like receptor 2
Sequence:
MEKRGQHEMEGVPAGCHSHIKLLRINREHLVTNIRNTQCLVDNLLENGYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRLWLSEIGFSPSQLIRTKTIVNTDPVSRYTQQLRHQLGRDSKFMLCYAQKEDLLLEETYMDTLMELVGFNNENLGSLGGLDCLLDHSTGVLNEHGETVFVFGDAGVGKSMLLQRLQSLWASGRLASKAKFFFHFRCRMFSCFKESDTLTLQDLLFKHFCYPEQDPEEVFSFLLRFPHTALFTFDGLDELHSDFDMSRVPDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTARTGVEVPRQLLRKKVLLRGFSPSHLRAYARRMFPERTAQEHLLQQLDANPNLCSLCGVPLFCWIIFRCFQHFHTAFEGSSQLPDCAVTLTDVFLLVTEVHLNRTQPISLMQRNTRSPAETLRAGWRTLQALGEVAHRGTDRSLFVFGQEEVQASKLQEGDLQLGFLRALPDVGPEQSQQSYEFFHLTLQAFFTAFFLVADDKVSTQELLRFFREWTSPGEATSRSCYPSFFSFQCLGSGSRLGPDPFKNKDHFQFTNLFLCGLLAKARQKLLQQLVPKAILRKKRKALWAHLFASLRSYLKSLPRVQSDGFNQVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKLAFCNACSADCSALSFVLHHFHRQLALDLDNNNLNDYGVRELQPCFSRLTVIRLSVNQITDMGVKVLCEELTKYKIVTFLGLYNNQITDIGARYVAQILDECRGLTHLKLGKNRITSEGGRCVAQAVKNSTSIVEVGMWGNQIGDEGAKAFAEALRDHPSLTTLSLAFNGISPEGGKSLAQALKQNTTLTIIWLTKNELNDEAAECFAEMLRVNQTLKHLWLIQNHITAEGTAQLARALQKNTTITEICLNGNLIKPEEAKVFENEKRIICF
Protein: ATP-dependent DNA helicase (EC 3.6.1.-) (A3F475)
Organism: Bacillus subtilis (strain 168)
Interaction partners:
Sequence:
DGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEHIHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRKKLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKIDRVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFIHNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRAPGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIHLFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGNLPCCSHCGFDLSL
Protein: Caspase 7 (A0A0G2K9Z4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MADSSTEDGVDAKPDRSTIISSLLWKKKKNASMCPVSTTRDRVPTYLYRMDFEKMGKCIIINNKNFDKATGMDVRNGTDKDAEALFKCFRSLGFEVTVYNDCSCAKMQDLLRRASEEDHSNSACFACVLLSHGEENLIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRNPGKGSWFVQALCSILNEHGKDLEIMQILTRVNDRVARHFESQSDDPRFNEKKQIPCMVSMLTKELYFGR
Protein: Aminopeptidase, putative (Q385B0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPTLPKAEAKELSAFVQSCVEYKTNVCFTDVTAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNATVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL
Protein: Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) (Q3SYX9)
Organism: Bos taurus (Bovine)
Function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O15511}. Cell projection {ECO:0000250|UniProtKB:O15511}. Nucleus {ECO:0000250|UniProtKB:O15511}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 1A
- Actin-related protein 3
- Actin nucleation-promoting factor WASL
- Actin nucleation-promoting factor WAS
Sequence:
MSKNTVSSARFRKVDVGEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAVLLQWHEKALAAGGVGSIVRVLTARKTV
Protein: Tocopherol cyclase, chloroplastic (EC 5.5.1.24) (Sucrose export defective 1) (Vitamin E pathway gene 1 protein) (Q94FY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the synthesis of both tocopherols and tocotrienols (vitamin E), which presumably protect photosynthetic complexes from oxidative stress. Catalyzes the conversion of 2-methyl-6-phytyl-1,4-hydroquinone and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (DMPQ) to delta- and gamma-tocopherol respectively. Converts also 2,3-dimethyl-5-geranylgeranyl-1,4-hydroquinone (DMGQ) to gamma-tocotrienol.
Subcellular location: Plastid, chloroplast, plastoglobule {ECO:0000269|PubMed:16414959, ECO:0000269|PubMed:16461379, ECO:0000269|PubMed:22274653}.
Interaction partners:
- Tocopherol O-methyltransferase, chloroplastic
- 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase, chloroplastic
- Homogentisate phytyltransferase 1, chloroplastic
- Eukaryotic translation initiation factor 3 subunit E
- Translation initiation factor eIF2B subunit beta
- Eukaryotic translation initiation factor 3 subunit A
- Translation initiation factor eIF2B subunit gamma
- Eukaryotic translation initiation factor 2 subunit alpha homolog
- Eukaryotic translation initiation factor 2 subunit alpha
- Eukaryotic translation initiation factor 3 subunit K
Sequence:
MEIRSLIVSMNPNLSSFELSRPVSPLTRSLVPFRSTKLVPRSISRVSASISTPNSETDKISVKPVYVPTSPNRELRTPHSGYHFDGTPRKFFEGWYFRVSIPEKRESFCFMYSVENPAFRQSLSPLEVALYGPRFTGVGAQILGANDKYLCQYEQDSHNFWGDRHELVLGNTFSAVPGAKAPNKEVPPEEFNRRVSEGFQATPFWHQGHICDDGRTDYAETVKSARWEYSTRPVYGWGDVGAKQKSTAGWPAAFPVFEPHWQICMAGGLSTGWIEWGGERFEFRDAPSYSEKNWGGGFPRKWFWVQCNVFEGATGEVALTAGGGLRQLPGLTETYENAALVCVHYDGKMYEFVPWNGVVRWEMSPWGYWYITAENENHVVELEARTNEAGTPLRAPTTEVGLATACRDSCYGELKLQIWERLYDGSKGKVILETKSSMAAVEIGGGPWFGTWKGDTSNTPELLKQALQVPLDLESALGLVPFFKPPGL
Protein: ATP-binding cassette transporter (A0A1D8PQ95)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- ATP-binding cassette transporter
- Multiple drug resistance-associated protein-like transporter 1
- ATP-binding cassette glutathione S-conjugate transporter
- Lanosterol 14-alpha demethylase
Sequence:
MSSEDIGSSSSSLQEYVGQQQHNKIQPSTDDDYNEDDYESRRLHLVRTVSSINHHNFDEKFDTISREISRQVTNKEGEFQLRLDEFNLAKILANFVYFAKKQGIVLRKSGITFQDLCVYGVDESFAIAPTVTDLLKGPVGAVQAILSQMKTPPRKILKNLNGFAKPGESVLVLGRPGAGCTTFLKALSGTDFDLYKGVTGDIRYDGLPQKEMLKLFKNDLVYNPELDVHFPHLTVDQTLTFAIACKTPEMRINGVTRDEFINAKKEILATVFGLRHTYHTKVGNDFVRGVSGGERKRVSIAEALACNGSIYCWDNATRGLDASTALEFAQAIRTSTKLLKTTAFVTIYQAGEGIYETFDRVTVLYDGHQVYYGPANKAKKYFEDMGWECPPRQSTAEFLTAITDPIGRFPRAGWENKVPRTAQDFEHYWLNSPQYQELMQEIKDYNDEIDEDETRSKYYQSIQQEKMKGSRTKSPFTISYLEQLKLCFIRSYQRILGDSAYTITLMFASVAQAFVAGSLYYNTPDDVSGAFSRGGVIFFAVLFMSLMGLAEISASFSSRPILMKQKNYTMYHPSADSLSNFVMSIPISIFINTFFVIILYFLSNLARDAGKFFICYLFVIMLHLTMKSMFQAIAAINKSIAGANAMGGILMLASLMYSSYMIQRPSMHPWFKWISYINPVLYAFEAVIASEFHGRKMQCTSQYLTPSGPGYENLGAGEQVCTFIGSVPGQSWVLGDDYLRIAYTYRFSHVWRNLGILFGFLAFFLAIATLGTEYVKPITGGGDKLLFLKGKVPEHITLPSEKKEEDIESGGNSDTTATSNGTLSQGKSEEKAAIVDDGLKAKGVFVWKDVDYVIPYEGKKRQLLQNVSGYCVPGTLTALMGESGAGKTTLLNVLAQRVDFGVITGDMLVNGRPLDTSFSRRTGYVQQQDIHFSEVTVRESLQFAARLRRSNDVSDAEKLEYVEKIIDVLDMRGYADAVVGRLGNGLNVEQRKKLSIGVELVAKPSLLLFLDEPTSGLDSQSAWAIVKLLRDLANAGQSILCTIHQPSATLFEEFDRLLLLKKGGIVTYFGDIGPRSRTILDYFERNGARHCDDKENPAEYILEAIGAGATASTDFDWGEIWAQSPEKVQTDAKRDELINESAKNATDTSATDSPSEKNLTSKYATPYWYQFRHVTHRTSLIFYRDPDYIAAKVFLMTIAGLFIGFTFFGLKHTKTGAQNGMFCAFLSCVIAAPLINQMLEKAGSRDIYEVREKLSNTYHWSLLILPQIIFEVIYMIIGGTIMFVCLYFPTQVSTVASHSGMFYFSQAIFLQTFAVSFGLMVSYVSPDIESASVIVSFLYTFIVSFSGVVQPVNLMPGFWTFMNKVSPYTYFIQNLVSSFLHDRTIRCNAKELSYFNPPSGQTCKEFASAFISRNGGYLVDEGATSNCGYCNFSNADQYLLTIGAKFSYRWRNIGFFCVYIIFNISVCLVLYYFLRYRKVSFNVTGLVNKFKKSKK
Protein: Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3) (Two pore K(+) channel KT3.3) (Q9H427)
Organism: Homo sapiens (Human)
Function: Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Delayed-rectifier potassium channel regulatory subunit KCNS1
- Keratin, type II cytoskeletal 2 oral
Sequence:
MRRPSVRAAGLVLCTLCYLLVGAAVFDALESEAESGRQRLLVQKRGALRRKFGFSAEDYRELERLALQAEPHRAGRQWKFPGSFYFAITVITTIEYGHAAPGTDSGKVFCMFYALLGIPLTLVTFQSLGERLNAVVRRLLLAAKCCLGLRWTCVSTENLVVAGLLACAATLALGAVAFSHFEGWTFFHAYYYCFITLTTIGFGDFVALQSGEALQRKLPYVAFSFLYILLGLTVIGAFLNLVVLRFLVASADWPERAARTPSPRPPGAPESRGLWLPRRPARSVGSASVFCHVHKLERCARDNLGFSPPSSPGVVRGGQAPRLGARWKSI
Protein: Autophagy-related protein 13 (Q06628)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Required for autophosphorylation of ATG1 at 'Thr-226' and its dimerization. May also be involved in the regulation of autophagy through SNF1. Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Preautophagosomal structure {ECO:0000269|PubMed:17295840, ECO:0000269|PubMed:21468027}.
Interaction partners:
- Autophagy-related protein 29
- Autophagy-related protein 17
- Autophagy-related protein 9
- Serine/threonine-protein kinase ATG1
- Autophagy-related protein 31
- Autophagy-related protein 11
- Vacuolar protein 8
- Putative lipase ATG15
- cAMP-dependent protein kinase type 1
- Autophagy-related protein 23
Sequence:
MVAEEDIEKQVLQLIDSFFLKTTLLICSTESSRYQSSTENIFLFDDTWFEDHSELVSELPEIISKWSHYDGRKELPPLVVETYLDLRQLNSSHLVRLKDHEGHLWNVCKGTKKQEIVMERWLIELDNSSPTFKSYSEDETDVNELSKQLVLLFRYLLTLIQLLPTTELYQLLIKSYNGPQNEGSSNPITSTGPLVSIRTCVLDGSKPILSKGRIGLSKPIINTYSNALNESNLPAHLDQKKITPVWTKFGLLRVSVSYRRDWKFEINNTNDELFSARHASVSHNSQGPQNQPEQEGQSDQDIGKRQPQFQQQQQPQQQQQQQQQQQRQHQVQTQQQRQIPDRRSLSLSPCTRANSFEPQSWQKKVYPISRPVQPFKVGSIGSQSASRNPSNSSFFNQPPVHRPSMSSNYGPQMNIEGTSVGSTSKYSSSFGNIRRHSSVKTTENAEKVSKAVKSPLQPQESQEDLMDFVKLLEEKPDLTIKKTSGNNPPNINISDSLIRYQNLKPSNDLLSEDLSVSLSMDPNHTYHRGRSDSHSPLPSISPSMHYGSLNSRMSQGANASHLIARGGGNSSTSALNSRRNSLDKSSNKQGMSGLPPIFGGESTSYHHDNKIQKYNQLGVEEDDDDENDRLLNQMGNSATKFKSSISPRSIDSISSSFIKSRIPIRQPYHYSQPTTAPFQAQAKFHKPANKLIDNGNRSNSNNNNHNGNDAVGVMHNDEDDQDDDLVFFMSDMNLSKEG
Protein: Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase alg10) (Alpha-2-glucosyltransferase alg10) (Asparagine-linked glycosylation protein 10) (Dolichyl-phosphoglucose-dependent glucosyltransferase alg10) (Q10254)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P50076}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dol-P-Man:Man
- Probable Dol-P-Man:Man
- Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Dolichyl-phosphate beta-glucosyltransferase
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3
- Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit ost2
- Probable tyrosyl-DNA phosphodiesterase
Sequence:
MFLGKAIILILWIFLAFTGLLAIQYYVPNPYLDEIFHIAQAQRFCRKDWDWDPAITTPPGLYLVSVALSPFIGCSNVSLRLINWLVGVIGLPWLINDIVSLLNNRKGDVVTYFAYTLSSLPPLWFFSFLYYTDIGSTFFVLLAYDFALRKSAFSSSVSCFFSLWFRQTNIVWMVFIAVTYFASNMSFFNPHLAEATFADVLLTIISFLGVFLKNLRRFSCPILSYGAVFCSFLAFLLWNGSIVLGDKSHHQASIHLSQINYFLWFFFFFSFPSYIIKYLMSHSRRSKLLSAVFSKKSFLIVSVLLLIAHFNTIFHPFILADNRHYLFYVFNRLFRIWWLKYLGPFSYLILYYFFLDISKLQMTSLTFFLLISTTILTLVPAPLVEFRYFLLPFLFWRFHLPLPSGRECLMEYALHMVINSVTLYIFLFRTFIWPSEPNALQRFMW
Protein: 26S proteasome non-ATPase regulatory subunit 1 homolog A (26S proteasome regulatory subunit RPN2a) (AtRPN2a) (26S proteasome regulatory subunit S1 homolog A) (O48844)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 12 homolog B
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- 26S proteasome non-ATPase regulatory subunit 3 homolog B
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome regulatory subunit 8 homolog A
- 26S proteasome regulatory subunit 6A homolog B
- 26S proteasome non-ATPase regulatory subunit 12 homolog A
- 26S proteasome non-ATPase regulatory subunit 7 homolog B
- 26S proteasome non-ATPase regulatory subunit 7 homolog A
- 26S proteasome non-ATPase regulatory subunit 4 homolog
Sequence:
MATPMVSSAGGLLAMLNEPHPVLKLHALSNLNNLVDQFWPEISTSVPIIESLYEDEEFDLHQRQLAALLVSKVFYYLGELNDSLSYALGAGPLFDVSEDSDYVHTLLAKAIDEYASLRSKAVESNEMVDIDPRLEAIVERMLGKCISDGKYQQAMGIAIECRRLDKLEEAIIKSDNVQGTLSYCINVSHSFVNRREYRHEVLSLLVKVYQKLPSPDYLSICQCLMFLDEPQGVASILEKLLRSENKDDALLALQIAFDLVENEHQAFLLSVRDRLPAPKTRAVEATQAVETTIAPNENPSGDVQMADETPAQTIVHETDPVDATYAERLTKIKGILSGETSIQLTLQFLYSHNKSDLLILKTIKQSVEMRNSVCHSATIYANAIMHAGTTVDTFLRENLDWLSRATNWAKFSATAGLGVIHRGHLQQGRSLMAPYLPQGGAGGGGSPYSEGGALYALGLIHANHGEGIKQFLRDSLRSTNVEVIQHGACLGLGLSALGTADEEIYDDVKSVLYTDSAVAGEAAGISMGLLLVGTATEKASEMLAYAHETQHEKIIRGLALGIALTVYGREEGADTLIEQMTRDQDPIIRYGGMYALALAYSGTANNKAIRQLLHFAVSDVSDDVRRTAVLALGFVLYSDPEQTPRIVSLLSESYNPHVRYGAALAVGISCAGTGLSEAISLLEPLTSDVVDFVRQGALIAMAMVMVQISEASDSRVGVFRRQLEKIILDKHEDTMSKMGAILASGILDAGGRNVTIRLLSKTKHDKVTAVIGLAVFSQFWYWYPLIYFISLAFSPTAFIGLNYDLKVPKFEFMSHAKPSLFEYPKPTTVPTANTAVKLPTAVLSTSVKAKARAKKEAEQKAIAEKTSGPEKPVNESGSGKGKASTEKEGDSMQVDSPAAVEKKAPEPEPAFEILVNPARVVPAQEKYIKLLDDSRYVPVKLAPSGFVLLKDLREHEPEVLSLTDAPTSTASPATGTAAAAQGTPASAMAVDDEPQPPQAFEYAS
Protein: Mid1-interacting protein 1-B (Q1LUV9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in stabilization of microtubules. May play a role in the regulation of lipogenesis (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9CQ20}. Cytoplasm {ECO:0000250|UniProtKB:Q9CQ20}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with microtubules. {ECO:0000250|UniProtKB:Q9CQ20}.
Interaction partners:
- Neurexophilin
- Neurexophilin
- LYR motif-containing protein 5B
- Monoacylglycerol lipase ABHD2
- Mid1-interacting protein 1-like
- Mid1-interacting protein 1A
Sequence:
MMQICDSYNQKNSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLDQEEEKEVTSFQDGDMYGSYVLLKSIRNDIEWGVLQAEERRKEKHGVTTTSLEVSRIEPNDKDLEKLFHYHLSGLHTVLAKLTRKANTLTNRYKQEIGIGGCGN