wanglab/gogpt-training-data huggingface dataset:
Protein: DExH-box ATP-dependent RNA helicase DExH17 (EC 3.6.4.13) (ATP-dependent DNA helicase homolog MER3) (EC 3.6.4.12) (Protein ROCK-N-ROLLERS) (Q5D892)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA helicase required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference-sensitive crossovers (class I meiotic crossover).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA mismatch repair protein MSH4
- DNA mismatch repair protein MSH5
- DNA mismatch repair protein MLH1
- Crossover junction endonuclease MUS81
- TPR repeat-containing protein ZIP4
- DNA mismatch repair protein MLH3
- Protein STABILIZED1
- E3 ubiquitin-protein ligase CCNB1IP1 homolog
- Zinc transporter 1
- Zinc transporter 2
Sequence:
MDTHTLKSVSDLPGNFRSAFSFRYFNSLQSECFPLCFHSDINMIISAPTGSGKTVLFELCILRLFSKSISKEGSFLHAKGALKTVYISPSKALVQEKLRDWNQKFNSWGISCLELTGDNETYSTKNIQDADIILTTPEKFDAVSRYRVTSGGLGFFSDIALVLIDEVHLLNDPRGAALEAIVSRLKILSSNHELRSSTLASVRLLAVSATIPNIEDLAEWLKVPTAGIKRFGEEMRPVKLTTKVFGYAAAKNDFLFEKRLQNYIYDILMQYSKGKSALVFCSTRKGAQEAAQKLAQTAMTYGYSNPFIKSREQLERLREASPMCSDKQMQSYILQGVGYHNGGLCQKDRSLVEGLFLNGDIQVICTTNTLAHGINLPAHTVVIKSTQHFNKEKGHYMEYDRSTLLQMSGRAGRPPFDDTGMVIIMTRRETVHLYENLLNGCEVVESQLLPCLIEHLTAEIVQLTISDITRAIEWMKCSYLYVRMKKNPENYAIKKGIPKDRVEKHLQELCLQKINELSQYQMIWTDTDGFVLKPEEPGRLMTKYYLKFETMKYIINTPTSYSLDEALHIVCHAEEISWIQLRRNEKKTLNDVNADKEGRLRFHINDNKGKRKKRIQTREEKLFVLANDWLTGDPSVHDLSMTQDANSICSNGSRIARCMKEYFIYKKNYKGTLSSTLLAKSLYQKLWDDSPYLLKQLPGIGMVTAKALHSMGVRSFEALAEADPRRIEIVTGRKYPFGNTIKESLSSLPPKVEIKVEEVDCQKQGISKLAVTLSRVSQPLQSTKRHYADLIVGSEEENLIHFHEKIRMEDFSSPYSVTVLLERPHQQTKVTVKADLIFEEYIGIDLHETLLLKKANNNKVNYKSENRMPQYYPPMASACIADDDNPVTSGPSNRKDKKDDMPSFKLIDDDSEEEKEPYVTMEEDDCVIINEHTVFDHIREKAKCFPSLNPLNPTSSPASGKSILKRKSLVENNSPELDPLFQYDSVFDLPTNTKDIKQSAQQITSPGYASFAEKTETERPFSDETIFNYIRKRSKNSPALATSKIENPITISSQEGRNAEISPYRTYGLLVSPATKIPRITSDAPSEILSFDISMVKRSDTSLEQTKGFCSTLAGKSNVSDSFLGFKSIFSFL
Protein: Choline/ethanolamine kinase (Q9GZF3)
Organism: Caenorhabditis elegans
Interaction partners:
- Peptidase S28
- Anion transporter SULP-1a
- STAS domain-containing protein.
Sequence:
MISAIGTLFAENSLESDVILEKVIELGSDYLRGGWALVEKSEVTVTQITGGQSNILYLATSASTKLSPDTPSCFLIRIHRQAPSQVFTETVVFSVLSERGLGPKLYGFFPGGRLEEFLPSRTLDVDSIKLPEIARQVGSLYPKYHDIEVPISKSAGALKFIKENLEGYKALGGKVLKMCPHSVKYDSMPSELTVEQIEQEIATFERWCKVFDETIVFSHNDLAPLNVLELNDTKEIVFIDFEYSSYNWRGFDLCMFLCENAFDYRDPTPPGLVIDQDYMENHPNLQIFCEAYIDTQYKMKTANPKQKFPLTEGRAAEVESLMLECKFFIPLVNMFWAVWSLRQHLAKYEIGMDLDVIASDRFSMYFHLKEQSRAIYEQFKK
Protein: Sodium channel protein type 7 subunit alpha (Nax channel) (Sodium channel Nav2.3) (B1AYL1)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000269|PubMed:17408578}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sodium channel regulatory subunit beta-1
- Sodium channel regulatory subunit beta-4
- Sodium channel protein type 5 subunit alpha
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Calcium/calmodulin-dependent protein kinase type II subunit gamma
- Sodium channel regulatory subunit beta-2
- Sodium channel regulatory subunit beta-3
- Sodium channel protein type 9 subunit alpha
Sequence:
MLTSPEPKGLVPFTTESLELIENHIAKKCNEDPEEEEGLKPSRNLEAGKRLPIPYGTLPRGTVSEPLEDVDPYYYVKRNTFMVLNRSRVIFRFNAVSIFCTLSPLNSLRRAAIKALVHPLFRLLILISVLTDSILMCMSNLPEWILAIENTLLGIYAFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRFSPLSSFLMLKTIRTFRILKIIPLNHGLQSIVMTLAQCLKKLFGAIALALFFLAVFSLLGMGLFMGNLKHKCLRWPEENENETLHNRTGSLNYSPERINFYYMEGAKYALLCGNRTDAGQCPEGYVCVKEGTNPDNGFTSFDNFGWSLLAMFRLMTQDYPELLYHQILYASGKVYMIFFVMISFWFAFYLTSLFLGILTMTYEKEKQRACEESGGLDPKCQQTVKELDEENDAAEMETTQIEMKKRSPTSINTTLDILEDTTLGHREEPETSRKKCPICWHKFIKTCFIWKCSPCWVKLNEFADRVITHPLADLFLVICIVLNICFLALEHFPMSEELRSLLHVGNLVFIGIYTIEMILKIIAMHPYGYFQISWNIFDSILVVLELTEILLADVEGLAVLITVPLIFIKLGKYGPPFKSLMRILGSSLMALKDLVLLLCIFVYFSAVFGMKLFGRSYKDCVCHIKEDCQPQRWHMSDFLHAYMTVFRILCGEWIETLWECMEVAGQAWCIPFYMMVILIGNLLILYLFVTLVSSFSYYDATSEVNKEAKNLQLAMARIKSGINSMLLKLMCTERSVPTEATDQICDPSVKENISGHTLSELSNTQTFLRYKDQSSSTEKTPVTESESQSLIASPSASETVPIASGESDIENLDNKETRSKSGNGGSKEKMKQSSSSECSTVDIAISEEEEMVYEHEKSKLHKNGYERKSSTGQISRESRNGKIWKNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTTKILLEYADMIFAYIFILEMLLKWVAYGFKAFFSNNWYKLDFMVVIVFCLSLIGKTREDLNPLTSIKFLRALRVLSQFERMKVVLRALIKTTLPTVSVFLVCLMIWLLFSVIGVQLFAGKFYECIDPTKGERFPVFEVMNKSQCEKLLFNESMPWENAKLNFDNVGNGFLSLLQVATFNGWISIMNSAIDSVGVNMQPSFEYNLYMYSYFIIFVIFGLFLPLCMLIGVIIRNFNKQKIKQGGSNIFITVKQKKQYRALKKLLYADVQKPTPRPRNKFQGFLFDLVTHRVFNVIIILLICFQATTIMIQKDEQSPQMETAIFWMNSIFVMLFTLECILKLTAFRCHYFTSAWNVHDFMVVIFSITGLLLPLTIGQYFVPPSLVQLILLSRVIHILRPGKGPKVFHDLMLPLILALPALLNISLLIFLVMFIYAIFGMYNFAYVKKEAGINDVSNFETFGSSMLCLFQVTTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVKGDCGSPSVGISYFVSYILISWLIIVNMYIVLIMEFLSIPSQKKSRTLSEDDFRRFFRVWNRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERVEKILSEIESGFMLANPFKITYEPITTTLKRKQEAVSATIIQRAYKSYRLRQNDKNVSDTPAIDDRRDDLTSKGAHSGKIEEKASIQTQI
Protein: Plexin-A2 (Plex 2) (Plexin-2) (P70207)
Organism: Mus musculus (Mouse)
Function: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:20881961}; Single-pass type I membrane protein {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:20881961}.
Interaction partners:
- Neuropilin-1
- Semaphorin-6A
- Semaphorin-3A
- Rho-related GTP-binding protein Rho6
- Semaphorin-3C
- Semaphorin-6B
- Rho-related GTP-binding protein RhoD
- Tyrosine-protein kinase Fyn
- Tyrosine-protein kinase Fes/Fps
- Ras-related C3 botulinum toxin substrate 2
Sequence:
MEQRRFYLRAMQADNLSVVLLSVAWLLLARGTTGMPQYSTFHSENRDWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPDGMAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGEALAQAFNISSDEDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYHGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVFKDGSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEANRFAASISQCMSLEVHPNSISVSDHSRLLSLVVNDAPNLSEGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINVSEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLSIQGAVHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADHKFECGWCSGERRCTLHQHCPSTSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPIPGEYIIAEQIVCEMGHAVIGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLSPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMNEIVCVSPPSSNGLGPVPVSVSVDRARVDSSLQFEYIDDPRVQRIEPEWSITSGHTPLTITGFNLDVIQEPRVRVKFNGKESVNVCTVVNTTTLTCLAPSLTSDYRPGLDTVERPDEFGFLFNNVQSLLIYNDTKFIYYPNPTFELLSPTGILDQKPGSPIILKGKNLCPPASGGAKLNYTVMIGETPCTVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIISIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRVPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYADIAKLPAISDQDMNAYLAEQSRLHATEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEHLINAMSIES
Protein: Alpha-endosulfine (ARPP-19e) (P60841)
Organism: Rattus norvegicus (Rat)
Function: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11279279}.
Interaction partners:
- Serine/threonine-protein kinase greatwall
- Misshapen-like kinase 1
Sequence:
MSQKQEEENPAEETGEEKQDTQEKEGILPEKAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGADKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE
Protein: BEM1-interacting protein 2 (P39969)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds to the BEM1 protein. Involved in bud formation.
Subcellular location: Bud {ECO:0000269|PubMed:12097146}. Bud neck {ECO:0000269|PubMed:12097146}. Note=Localizes to the periphery of buds during much of the budding cycle and to necks late in the cell cycle. {ECO:0000269|PubMed:12097146}.
Interaction partners:
- Bud emergence protein 1
- Cell division control protein 24
- BEM1-interacting protein 1
- GTP-binding protein RHO3
- Cell division control protein 42
- 26S proteasome regulatory subunit RPN10
- GTP-binding protein RHO4
- High osmolarity signaling protein SHO1
- Bud site selection protein 6
- 26S proteasome regulatory subunit RPN13
Sequence:
MSNDREVPTLSQLNTTVSRDKDVSDTLSPDFDSKGSATGRDGGNFPMYIAINEYFKRMEDELDMKPGDKIKVITDDEEYKDGWYFGRNLRTNEEGLYPVVFTQKITVEKAPTLMRAKSTKRIYSPLTNEDPLLSSTFISENDSNSELPTPQPIETAASISRTANGKIERNLSLKNTMSDIDNALLEFKDDSIGPPDRFINSGRDEEHSITHETILSATDGLDVVESNSKPTTSSSTGFLNGDLENQATLINGIDTTKLNPVEAEFWSPEEITAYFIMEGYDVQSASRFQKHKISGKILLELELVHLKELDINSFGTRFEIFKEIEKIKEAIRTNGRSLNRASKTNNANIYNQLMPPANVDQRASYRGHVRKTSQSLEDLPSQQNFIPTPRNTRNSSASKHRPKSLVFDSQEANANIAPDVQIPQVVEEMAGNENLFVSPRRAPKPPSYPSPAQPPKSPLLNNTRTSPSPAQLYSWQSPTLSFSGPKRTSYIDQYSSSDSNFNSRSALPKNNQGGGKALSPIPSPTRNSVRNEDSEGKLTSSSKRNSVPYYGYAPESSSDRKSSCSSHEEEQFQETMNTFERPTSSIYADGSTIASISNDKLAHEKEGKKKPTRHSSSLSSKSKSDSRRNSSLKRSSSASRTSSFKKSSFMLSPFRQQFTDNAARSSSPEENPITSMPSEKNSSPIVDKKSSKKSRSKRRSVSAKEAEIFTETVKDDKNKRSASEAIKGETLKGKSLRQMTARPVAKKKQTSAFIEGLRSISVKEAMKDADFSGWMSKKGSGAMSTWKTRFFTLHGTRLSYFSSTTDTRERGLIDITAHRVVPAKEDDKLVSLYAASTGKGRYCFKLLPPQPGSKKGLTFTQPRTHYFAVDNKEEMRGWMAALIKTTIDIDTSVPIISSYTTPTVSLSKAQEMLAEAREETKLREQQMLENEEDEDQFLWDQQQLQQQQHDNNQGQADRTISASTQRTSDEDNTISTPNLSSANNTTIGSNGFSSPFLLASGLLSPGVARNSSMRGTEKKGKFSTEEDYFGDNSKHKTDKI
Protein: Solute carrier organic anion transporter family member 6C1 (Q8C0X7)
Organism: Mus musculus (Mouse)
Function: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000269|PubMed:34225353}.
Interaction partners:
- EF-hand calcium-binding domain-containing protein 9
- Cation channel sperm-associated auxiliary subunit epsilon
- Cation channel sperm-associated protein 1
- Cation channel sperm-associated auxiliary subunit zeta
- Cation channel sperm-associated auxiliary subunit beta
- Cation channel sperm-associated protein 4
- Cation channel sperm-associated auxiliary subunit delta
- Cation channel sperm-associated protein 2
- Cation channel sperm-associated protein 3
- Cation channel sperm-associated auxiliary subunit TMEM249
Sequence:
MAHVRNKKSDDKKAMVVAKEDTNKSESEGVTKLQTYLKTIPIAKKKFAKLPKRKKSPTSAELLLIDPRYSASKEGPLGLGPIVLPFVQRFNNIDGFMTLYVAAVLIHGALFAVVDMTLNIYQVQFSLTRTEWYLMDFSDYIASFVVAIIIAHFGSKGNRTRWIAASCILMGLESMLFAFPFFTYEIIIPGRQSIELCMEENEKRNIICGNSVPNRSKCIYFHIAGQCIHGIAGMPIYILGITFIFDHIPTSSCGFYLAIGHSAYLIGYLLGMVGGLQNFQPPPKEKTVEIEPAKVYQLLQSGWWKTFLIIAAISFCVSFMMVCFPTSLPGAHKLRLAKRKEPPTIDRRLKDMKIQPHLKGFLHNIWHILKNPLMLTQAICKVSEYLTFNTSLYFLPHHLQTQFLITPGIASLLTGAFVLPGGIIGHFLGGLIVDRLEMTNKNKLKFTLVTTVVSVGLFLLIFFVECQTTTFAGINEDYDGYGQLGNLTADCNEYCDCTTSLYTSICGRDEKEYFSPCFAGCKATKVSQTEKTYYNCSCIKEGLAASDDEGQFIDAIAGTCDSDCLKLPLFFAFYFSATVFSNMCSIPVISIILQSVPANFTSLSLGVTYAIVKFVASVPAPLLFRLSSAIACIYWDNNRCGGKERCWIYNKNILVYEFMGIWMSSQLIIVLLNIYAIQIHDVVVHGEITESKTTVKDVKEQKERKA
Protein: Probable 26S proteasome regulatory subunit rpn-6.1 (Q20938)
Organism: Caenorhabditis elegans
Function: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.1 is required for proteasome assembly. Plays a key role in increased proteasome activity in response to proteotoxic stress: induced by daf-16, promoting enhanced assembly of the 26S proteasome and higher proteasome activity, leading to extended lifespan.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 7
- PCI domain-containing protein
- Proteasome subunit alpha type-5
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 3
- 26S proteasome non-ATPase regulatory subunit 8
- 26S protease regulatory subunit 6A
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome non-ATPase regulatory subunit 6
- 26S proteasome non-ATPase regulatory subunit 2
Sequence:
MRETSSREDTNNIGKAPEMSGGTIMDTMTSLPHQNDQNVIRHLTNLVKSPASGDDDIKKKEDSIMELGNILAQNKQTEELRNMIEQTRPFLVSLGKAKAAKLVRDLVDLCLKIDDQDGDIKVGLVKECIQWATEQNRTFLRQTLTARLVRLYNDLQRYTQALPLAADLIRELKKVDDKDVLVEVELEESKAYYNLSNIGRARASLTGARTTANAIYVNPRMQAALDLQSGILHAADEKDFKTAFSYFYEAFEGYDSVDEKVSALTALKYMLLCKVMLDLPDEVNSLLSAKLALKYNGSDLDAMKAIAAAAQKRSLKDFQVAFGSFPQELQMDPVVRKHFHSLSERMLEKDLCRIIEPYSFVQIEHVAQQIGIDRSKVEKKLSQMILDQKLSGSLDQGEGMLIVFEIAVPDEAYQTALDTIHAMGEVVDALYSNASKIN
Protein: Multiplexin, isoform T (X2JC42)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRVLQGVMFALAMICTLLVPVLGSFELVGQSIKDALAEYTLTDIMNNNQFAGIEFGEAEDGFPAFRFLQTADVKSPYRMLLPEKLYEFAILITFRQSSLKGGYLFSVVNPLDTVVQLGVHLSPVVKNSYNVSLVYTQADQNIGRKLASFGVAHVPDKWNSIALQVLSDKVSFYYDCELRNTTLVTREPIELVFDSASTLYIGQAGSIIGGKFEGYLEKINVYGNPDAINVTCMPPPKATIAPTTADDGSIFYEGSGENILFEDSTEANILSDDFWNTGDEATDIFDASGMQPPGQTQYTHERPYRGIKGEKGERGPKGDSIRGPPGPPGPPGPKGETAPYPPFVETTSAGAKYTGECTCNASDILEAIKDNESLRESLRGAPGTPGKDGKPGTPGHTGATGVPGARGARGSEGAQGLKGEPGVDGLPGVMGPPGPPGPPGLPENYDESLMVNSMGAFRGTTQPGAKGVPGEKGDAGQKGERGDPGHKGAHGPSGAKGEPGEPGTPGLPGLPGQVGQPGGLDGLASANGTKGEKGEKGEKGMRGRRGGTGATGPIGPPGKPGPMGDIGHSGRPGMTGPKGEMGPKGPKGDSGGREGLKGDKGDRGQDGRDGLPGPPGLPSTGGGDGDSGGVQYIPMPGPPGPPGPPGLPGLSISGPKGEPGVDSRSSFFGDASYYGRPEPPRQPGHSHKHEETLGLVDGEEPYFSASSSNMNMKIVPGAVTFQNIDEMTKKSALNPPGTLAYITEEEALLVRVNKGWQYIALGTLVPIATPAPPTTVAPSMRFDLQSKNLLNSPPPLLNTPTFTTAPEYETWYPRMLRVAALNEPSTGDLQGIRGADFACYRQGRRAGLLGTFKAFLSSRVQNLDTIVRPADRDLPVVNTRGDVLFNSWKGIFNGQGGFFSQAPRIYSFSGKNVMTDSTWPMKMVWHGSLPNGERSMDTYCDAWHSGDHLKGSFASNLDGHKLLEQKRQSCDSKLIILCVEALSQDRKRKKREIGDGSSHGESESREFKTADEYAAHLENLLL
Protein: F-box/kelch-repeat protein At1g74510 (Q9CA63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Wall-associated receptor kinase-like 14
- Ubiquitin-conjugating enzyme E2 20
- Glucan endo-1,3-beta-glucosidase 14
- Protein FIZZY-RELATED 3
- Ubiquitin carboxyl-terminal hydrolase 1
Sequence:
MLEAPSYLVSRDLPSSCEEESKWIYNAHCVLQLSLRKRLLDDTDVEGSSAKKMLRVDHGSRGESDKITDSLQLAKTYQSSNQSQQGGGGDQQSSPVTRLDQNALLNCLAHCSLSDFGSIASTNRTFRSLIKDSELYRLRRAKGIVEHWIYFSCRLLEWEAYDPNGDRWLRVPKMTFNECFMCSDKESLAVGTELLVFGKEIMSHVIYRYSILTNTWTSGMQMNVPRCLFGSASLGEIAVIAGGCDPRGRILSSAELYNSETGEWTVIPSMNKARKMCSSVFMDGNFYCIGGIGEGNSKMLLCGEVYDLKKKTWTLIPNMLPERSSGGGGDQAKEIAAATAASEAPPLVAVVKDELYAANYAQQEVKKYDKRLNVWNKVGNLPERASSMNGWGMAFRACGDQLVVVGGPRAIGGGFIEINACVPSEGTQLHWRVLASKPSGNFVYNCAVMGC
Protein: TatD related deoxyribonuclease, putative (Q385F9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- methionine--tRNA ligase
Sequence:
MSSVTAKYLPMIDIGINLVDGMFSGVYHGHVKHPGDVESVLARAVAVGVKCLLITAGTVEESKSAIELCRKYNSDGLQCFCTVGCHPTRCNEFANEPENYFNVLRSLIFENTVRKEGGCVAAVGELGLDYDRVSFCEKDVQMTYFVKQLELAEEFQLPLFIHDRNTGDDLFTVLQRHRQRFPGGVVHSFTGTQGELNKLLSLDLYIGINGCSLKTEENLAVAGAVPLDRLMIETDGPWCEIRNTHASHRLLQRAAERGESVADSLLAQFPICRKEKFVDGSVVKSRCEPCHLIRVLEILYELHRESVENIESLAHRIYNNTRQLFPFRPCHPDG
Protein: LSDAT_euk domain-containing protein (G5EGP7)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRRRFEKLRREKKEEKKLLADDEKDFDEDDDVFEDGEGLQMRTFQPNASIRDENGSMPSLLPRTAPIKKTRKHRRRRSGSFTGGVYPRKGHRNRSLLGHAIPPPNVHSADWRDMLAITDNKDDKLMKTLGVTRYLQSKGGDQVPPTSTTTGGAGGDGNAVPTTSQAQAQTFNSGRQTTGMSSGDRLNEDVSATANSAQLVLPTPLFNQMRFTESNMSLNRHNWVRETFTRRECSRFIASSRDLHKCGCGRTRDAHRNIPELTSEFLRQKRSVAALEQQRSISNVNDDINTQNMYTKRGANEKWSLRKHTVSLATNAFGQVEFQGGPHPYKAQYVRVNFDTEPAYIMSLFEHVWQISPPRLIITVHGGTSNFDLQPKLARVFRKGLLKAASTTGAWIITSGCDTGVVKHVAAALEGAQSAQRNKIVCIGIAPWGLLKKREDFIGQDKTVPYYPSSSKGRFTGLNNRHSYFLLVDNGTVGRYGAEVILRKRLEMYISQKQKIFGGTRSVPVVCVVLEGGSCTIRSVLDYVTNVPRVPVVVCDGSGRAADLLAFAHQNVTEDGLLPDDIRRQVLLLVETTFGCSEAAAHRLLHELTVCAQHKNLLTIFRLGEQGEHDVDHAILTALLKGQNLSAADQLALALAWNRVDIARSDVFAMGHEWPQAALHNAMMEALIHDRVDFVRLLLEQGINMQKFLTISRLDELYNTDKGPPNTLFYIVRDVVRVRQGYRFKLPDIGLVIEKLMGNSYQCSYTTSEFRDKYKQRMKRVKHAQKKAMGVFSSRPSRTGSGIASRQSTEGMGGVGGGSSVAGVFGNSFGNQDPPLDPHVNRSALSGSRALSNHILWRSAFRGNFPANPMRPPNLGDSRDCGSEFDEELSLTSASDGSQTEPDFRYPYSELMIWAVLTKRQDMAMCMWQHGEEAMAKALVACRLYKSLATEAAEDYLEVEICEELKKYAEEFRILSLELLDHCYHVDDAQTLQLLTYELSNWSNETCLALAVIVNNKHFLAHPCCQILLADLWHGGLRMRTHSNIKVVLGLICPPFIQMLEFKTREELLNQPQTAAEHQNDMNYSSSSSSSSSSSSSSSSSDSSSFEDDDDENNAHNHDQKRTRKTSQGSAQSLNITSLFHSRRRKAKKNEKCDRETDASACEAGNRQIQNGGLTAEYGTFGESNGVSPPPPYMRANSRSRYNNRSDMSKTSSVIFGSDPNLSKLQKSNITSTDRPNPMEQFQGTRKIKMRRRFYEFYSAPISTFWSWTISFILFITFFTYTLLVKTPPRPTVIEYILIAYVAAFGLEQVRKIIMSDAKPFYEKIRTYVCSFWNCVTILAIIFYIVGFFMRCFGSVAYGRVILACDSVLWTMKLLDYMSVHPKLGPYVTMAGKMIQNMSYIIVMLVVTLLSFGLARQSITYPDETWHWILVRNIFLKPYFMLYGEVYADEIDTCGDEAWDQHLENGGPVILGNGTTGLSCVPGYWIPPLLMTFFLLIANILLMSMLIAIFNHIFDATDEMSQQIWLFQRYKQVMEYESTPFLPPPLTPLYHGVLILQFVRTRLSCSKSQERNPMFDFSLKLFLDNDQIEKLHDFEEDCMEDLARQKLNEKNTSNEQRILRADIRTDQILNRLIDLQAKESMGRDVINDVESRLASVEKAQNEILECVRALLNQNNAPTAIGRCFSPSPDPLVETANGTPGPLLLKLPGTDPILEEKDHDSGENSNSLPPGRIRRNRTATICGGYVSEERNMMLLSPKPSDVSGIPQQRLMSVTSMDPLPLPLAKLSTMSIRRRHEEYTSITDSIAIRHPERRIRNNRSNSSEHDESAVDSEGGGNVTSSPRKRSTRDLRMTPSSQVEESTSRDQIFEIDHPEHEEDEAQADCELTDVITEEEDEEEDDEEDDSHERHHIHPRRKSSRQNRQPSHTLETDLSEGEEVDPLDVLKMKELPIIHQILNEEEQAGAPHSTPVIASPSSSRADLTSQKCSDV
Protein: PH and SEC7 domain-containing protein C11E3.11c (O13690)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- UBA domain-containing protein 3
- ADP-ribosylation factor 6
- Protein transport protein sec73
- ADP-ribosylation factor 1
- Guanine nucleotide exchange factor MSS4 homolog
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase ptn1
- Protein pal1
Sequence:
MSRNASNAYLKNGNSTPSNDKRSPSSLSQRSKTSTRSSKPFLQRLFPSTWFKNESSSRHPLTSIKENDTQTIGRRPSMRVKLFGKDKSKASMSTNDLPSHPRSQSVMGFSSSTSQLTGTSNSSRTRLNKDMRRDFGMTSMSSITSSTPTPSQLPVRPSTSLSFFDDIPLGPSFSAETILSSLSISTSNNAMSKTTPAPPLVTTKSISADQDDFYTCKEEVSTYEGLNSQIELSPVKSRDSQNKSAKNLSTAYRTVSGESRNLMVDPKVSPYGNSRTPLRDSSNYLRDRRSINRQSSLSIPKSTSETTRKTLALSNGGIDQSRVSSDSFKVDDSSAKMAAIDIWEGSQHIVSNDKALSWLVTDKPYNKAVLKHYISLYDFENTDILQSLRMICGNLYVHGETQELDHFLGEFSNQWCRTNPKGLFCNPQIVHSIAFSLLLLNTDLHIAELSASERMSRNQFVENTYRSIKQALNDSFDGNEEKKNAFFLSSYKSFASNESCNSPAIHSLHGNLSPGKSAELKKLHKRSLSSKVLEEAFSSYWMSALKEMYHSIKVSMILQPDRYLDMNFDFNDTNKINNPSSTANQTRHFHSVSEIKKLPMGTDELEKSMVRPSTAMYINRQNENAVSIDKSRDLQGTVNTKEIRSRSALSYQNDRPLATDLPSVIYNHKHPNVVSPFYVHPYIKQGILKFQSKESHKFRKKEVWSTVLAVLQRDVFTLYNLNTPNLSYDPKDLDISKVGKPVIKTTIIASLAKPFPSSEDAVVLKSTNSLYFDLETSSQLKLRFAGPSPKDAQGWIDALNYWAARSSKVPLLGGVTNVDYGWARCTGQRAQKSNAQLLKTKTDKIIVHKWQPQPVNTIPSSLSLGEQLSAFNNFMKLLKKTNDEHQNLHKEMLVVLSSQPKSTFRRAVENWKYKSDYLQLNLVRLRVYISVLEKYKSQAQNS
Protein: 3-demethoxyubiquinol 3-hydroxylase (EC 1.14.99.60) (2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase) (P75728)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the hydroxylation of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:30686758}.
Interaction partners:
- Ubiquinone biosynthesis O-methyltransferase
- Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
- Ubiquinone biosynthesis accessory factor UbiK
- Ubiquinone biosynthesis accessory factor UbiJ
- 2-octaprenyl-6-methoxyphenol hydroxylase
- 4-hydroxybenzoate octaprenyltransferase
- 2-octaprenylphenol hydroxylase
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
- 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
- Probable protein kinase UbiB
Sequence:
MTNQPTEIAIVGGGMVGGALALGLAQHGFAVTVIEHAEPAPFVADSQPDVRISAISAASVSLLKGLGVWDAVQAMRCHPYRRLETWEWETAHVVFDAAELKLPLLGYMVENTVLQQALWQALEAHPKVTLRVPGSLIALHRHDDLQELELKGGEVIRAKLVIGADGANSQVRQMAGIGVHAWQYAQSCMLISVQCENDPGDSTWQQFTPDGPRAFLPLFDNWASLVWYDSPARIRQLQNMNMAQLQAEIAKHFPSRLGYVTPLAAGAFPLTRRHALQYVQPGLALVGDAAHTIHPLAGQGVNLGYRDVDALIDVLVNARSYGEAWASYPVLKRYQMRRMADNFIMQSGMDLFYAGFSNNLPPLRFMRNLGLMAAERAGVLKRQALKYALGL
Protein: Vacuolin-B (Q54WZ2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Negative regulator of late steps of the endocytic pathway.
Subcellular location: Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Note=Post-lysosome.
Interaction partners:
Sequence:
MIESSSFMKKTSSENSIGSRSNIHEASTFSSEHENGDQSLTISQIVIRSDFANETSERQSKIILERFNEGIKNTAFTDSPVLGRAQPRLDVSYFAMAHRNQIVELFDPRGQRFGTVYSADPTVEIRYLGSVAKTCRYFGSFGKHVLNVPSGHFAKAMTKNRPIIYGEGPHVIIDPTFEFDERYGFVNQQEPFINHSTINILRVPSGKVAKVWIGTQPLILESRREPYVFVDAQFKMVEDTSESGNNKYFKNSSATFMEHGSIKRIIPHTGEVAITYNNGILTIIPPPKDGKPVIIDSPTHNFEGFIQTSLQTCLFPSKETKQQAIKDNKNATSDEVNLKIFQTRDSLRVGVVLVVAFRIVDPEIALTKLGKEGIINHIENVSFADMGKAIQLSTLQEIMYFNDTKPSANSTNETVHTIQDRVKSHLARDLCEYGIELARLQIETMKVLDSEIAKKLAGQSVTSAEFTTKQATLVKEYDIKTTEARLKAETDNIALEQKGKAIIAEAQAKLESAQKQAQALLITAEAQKKVQEMQGELFTKYPILAEIELAKIKSEALKSATLYITPQDAGNFMNSPLVYMDRLLGHQQKLEK
Protein: Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII) (P43166)
Organism: Homo sapiens (Human)
Function: Reversible hydration of carbon dioxide.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- 1,25-dihydroxyvitamin D
- 2,4-dienoyl-CoA reductase [
- Oxidative stress-induced growth inhibitor 2
- Calretinin
- Carbonic anhydrase 1
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
Protein: Mesoderm-expressed 2, isoform B (SD09884p) (Q9VNP3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAPVSGCLPTATHSLQDMSAAAAAIALDMKPKLEPHPLAAATAMPSQKIKKLVRRNASDKLKLIQMVHDNPILWDSRLPNFKGAEEEKNRAWEHIGREFNAPGRRVARAFKSLRESYRRELAHVKLMGNGFKPKWSLYEAMDFLRDVIRERKGASHATDLSLTTYGHINNNNNNNNNSNSLAAGGKAMTLKLSNSFNESASVLNLSKCSSLNVSDDHYYCDYYVKPELDLSVGGGAGSSTSGSSSGGGPLPLPAHQAHNDSRVSSTRNEQRAQHHSYEDMDDSSIRSGDEDIAHASDVVEELDAIDADFPYPLILDSNSRGSPNVGVDDVVMSRKLRRNVDQDVLEEGNGHGDAVIDGDDYEEQMLQQHRHLRQQQGVASGGLDLPPPQTVREVLNSKFCGFISAKLNSMEDSDADNLMNRILLLLVQVQQCEGSTK
Protein: Copper binding protein 1 (Mavicyanin-like) (F4YAW0)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MAIVNMVMAVVIMAATLGGKLGAAQVHHVVGGDRGWDLSSDVASWSSGRSFRVGDKIWFAYAAAQESIAEVNSPEEYESCDVSNPIRMYTDGIDGIPLDGEGIRYFVSGKEESCKNGLKLHVEVMPFGNPEPEKPRVAVAAAAPTTPSGSARLYGSSVLLLVGLWLCHMAI
Protein: Short-chain dehydrogenase, putative (Q383S7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQLLSWSSAAKALFGLTVARLLLAFLYRRLYRHLYYHPLVPGSVALITGGGSGMGLEFARYFARARCHVVLVGRDADALRSALASCVELGSPSAEMVVADLNTIEGTNLVCFGLRDIIEQKRLHGQFRYLVLNAGLGAILPFSSGVHFYETCESVMQINYFANVRLLQGLLSLLEETHSAANPSRVIVVSSLAGVLPSVLRSAYTASKHAIQGFANALRGETEVAITLFCPGYVDTDFHSKATLIKGDGAPVTSHRRGMAPDVAVGKCMEGVLSGRSEVLTPFVGKLGYILRPLFTRLVDSRAKKMSHRSLQK