wanglab/gogpt-training-data huggingface dataset:
Protein: G protein-coupled receptor associated sorting protein 3 (Protein BHLHb9) (bHLHb9) (Q6PB60)
Organism: Mus musculus (Mouse)
Function: Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6PI77}. Nucleus {ECO:0000250|UniProtKB:Q6PI77}. Note=Mainly cytoplasmic, and nuclear at lower level. {ECO:0000250|UniProtKB:Q6PI77}.
Interaction partners:
- Adhesion G protein-coupled receptor L1
Sequence:
MTGSKNKARAQAKLEKRASAQARAVAEREAANANRGAGKSRDKGKGKAGSKSDAVAEVKAGSKGKVVAETKEGARPESKALVKGTSDFNHRTENKFARSTRKDKPSSDNWFWAGEDSGINSWFWKGEELSNNSVAKCENKPSTSIQARAEEPAPRTSHKSRSGAEEEEEENVIGNWFWEGDDTGFDTDPKPVFKIVKPQPVDEINEKDRPKDWSEVTIWPKAPAVTPAVLGYRSQDSSEARSSSYIVLASNEEETSTACTKNTRSSLQSIPEYPFGSDPCIQTLDEIRQQIKIREENGIKPFACPCKLECYLDSPEFEKLVNILKSTTDPLIHKIAQIAMGIHKVHPFAQEFINEVGVVTLIESLLSFSSPEVSIKKAVITLNSSGDDRYNKVEFHVKHMCKETVSFPLNSPGQQSGLKIIGQLTTESVHHYIVVSYFSELFHLLSQGNRKTRNLVLKVFLNMSENPKAARDMINMKALAALKLIFNQKEAKANLVSAVAIFINIKEHIRKGSIVVVDHLSYNTLTAIFREVKGIIERM
Protein: Transcriptional adapter 1 (Transcriptional adapter 1-like protein) (Q8IP99)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- SAGA complex subunit Spt3
- SAGA complex subunit Spt20
- Transcription-associated protein 1
- Transcriptional adaptor 3, isoform C
- Transcription initiation factor TFIID subunit 12
- SAGA complex subunit Spt7
- Transcription initiation factor TFIID subunit 10b
- Transcription initiation factor TFIID subunit 9
- Protein will decrease acetylation
- SAGA-associated factor 29kDa
Sequence:
MLTDRVLATKEALVVALGDNWERYRANMKNWFRSRWTKEEFDAESRKILTPDKLHLHNQFLLALLNKIDAFAPLENPPAVQTSSSSGNRSKRRKRSCRTFAERLNFELSDVLDFVAEDNMQIIRPPTTIGIPSDQQQQQLQSQRYCAQELFLPDAGFIMGRFLIGAWEIGLVSVDDNVAEYVAMAVQVLLKDLLSAIIKKRKHYKTSGEGNFYYDVGAPLRDPSLRNTVTRQKVDDTPLELDKELNTANFMRRQNDDVTFLSACEEVQPTERTVITLKDCQLALRDRNLIGSHAVYSINMERLNMMMH
Protein: Protein Tat (Transactivating regulatory protein) (P69697)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)
Function: Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. In the absence of Tat, the RNA Pol II generates short or non-processive transcripts that terminate at approximately 60 bp from the initiation site. Tat associates with the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation. This binding increases Tat's affinity for a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) and allows Tat/P-TEFb complex to bind cooperatively to TAR RNA. The CDK9 component of P-TEFb and other Tat-activated kinases hyperphosphorylate the C-terminus of RNA Pol II that becomes stabilized and much more processive. Other factors such as HTATSF1/Tat-SF1, SUPT5H/SPT5, and HTATIP2 are also important for Tat's function. Besides its effect on RNA Pol II processivity, Tat induces chromatin remodeling of proviral genes by recruiting the histone acetyltransferases (HATs) CREBBP, EP300 and PCAF to the chromatin. This also contributes to the increase in proviral transcription rate, especially when the provirus integrates in transcriptionally silent region of the host genome. To ensure maximal activation of the LTR, Tat mediates nuclear translocation of NF-kappa-B by interacting with host RELA. Through its interaction with host TBP, Tat may also modulate transcription initiation. Tat can reactivate a latently infected cell by penetrating in it and transactivating its LTR promoter. In the cytoplasm, Tat is thought to act as a translational activator of HIV-1 mRNAs.
Subcellular location: Host nucleus, host nucleolus {ECO:0000255|HAMAP-Rule:MF_04079}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04079}. Secreted {ECO:0000255|HAMAP-Rule:MF_04079}. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type. {ECO:0000255|HAMAP-Rule:MF_04079}.
Interaction partners:
Sequence:
MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRPPQGSQTHQVSLSKQPTSQSRGDPTGPKE
Protein: Protein ARV1 (Q9D0U9)
Organism: Mus musculus (Mouse)
Function: Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9H2C2}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGTGGRRGTRSGKGTEGAAATSSSCLYRCIECNREAQELYRDYSHGVLKITICKSCQKPVDKYIEYDPVIILINAILCKTQAYRHILFNTKINIHGKLCMFCLLCEAYLRWWQLQDSSQSPAPDDVIRYAKEWDFYRMFVIASFEQAAFLTGIFAFLWVQQPMTAKRAPDFVLLLKALLLSSYGKLLLIPAVIWEHDYTPLCLRLIKVFVLTSNFQAVRVTLNTNRRLSLLVVLSGLLLESIVVFFFQRMEWDVSSDCALYKSQDF
Protein: TLC domain-containing protein (Q93892)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAEALSRWQEGLNRIEAAPFHFFTLDNNSDVGVPSAVGAELEMPDYWGFVNSIFLPTVVFYTLLWFAVYACVQYNCWLSWQEGIKRKRLLNLTTSLIHSTISGLYLFAFFCYNTKLMFAAPLHYYTYLDSQIITLSIGYFFYDGIDLVMNDKLSISTGVLLFHHVASIYVLSTAVLSKKFLLYAYWAMLMEVSSIFLHTRSILHISKLSTTSMIGFSKVVSYLNLITFIVFRGFVQFFLFGWAWVNYDHIHFIFKCIAFGGGFCFAVINVSLLLRILHSDGFLLSSVVSQDRLDALLEDNEYSNSSESVAKSEKKELLDV
Protein: Notch-regulated ankyrin repeat-containing protein A (Q7T3Y0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development.
Interaction partners:
- Neurogenic locus notch homolog protein 1
Sequence:
MSQADISTCSAPQRVFQEAVKKGNTKELHSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANREGWSALHIAAFGGHQDIVLYLITKAKYSSGAR
Protein: FMRFamide peptide receptor frpr-18 (FLP2 receptor) (G5EEB1)
Organism: Caenorhabditis elegans
Function: G-protein coupled receptor for flp-2 neuropeptides. May act through the G(q) alpha type of G proteins. Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide pdf-1.
Subcellular location: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- FMRFamide-like neuropeptides 2
- Neuropeptide receptor 3
- G-protein coupled receptors family 1 profile domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- FMRF-Like Peptide
- Pigment dispersing factor homolog pdf-1
- G-protein coupled receptors family 1 profile domain-containing protein
- Putative neuropeptide Y receptor 11
Sequence:
MESQQLMACAILVIVLVGIFGNSLSFILFSRPHMRSSSVNVLLCALSFFDFSLLTLSIPIFVIPNLDLWANDLSLSTYMAYILKLIYPINLMMQTCSVYIMVMITLERWVAVCRPLQVRVWCTPRKSRNAILVIIVSAFLYNFVRFFEYRFVVTESGALYEKWLRDPGKHRWYYVGYYTILYIVTHFLVPFSVMAFANGHVIVAMCKLSKTRQMLTRQQQREQSTTVMLLIVTFVFAICNTLPFLLNVSESIFPTLFQDESTRGLAYWLNDLSNLLVVLNSGTTFIIYFTFSEKYRQTLVFILKNGCCATVSDYNNYTAMSRTASMRISSETGGQIQRQGSKMSNSSRSSDVLLKPIYMQKRSERFSSEYNERTCKHLAPFEEHKLPKLPSEKRKKKLHKMSAVEHRGMPEITITFSEDLPDGEPDSPCQPC
Protein: Allatostatins MIP (B-type Allostatin preprohormone) (Myoinhibitory-like protein) [Cleaved into: Drostatin-B1 (MIP-1); Drostatin-B2 (MIP-2); Drostatin-B3 (MIP-3); Drostatin-B4 (MIP-4); Drostatin-B5 (MIP-5)] (Q9VVF7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Ligand for the sex peptide receptor (SPR). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat. May also have a regulatory role in gut motility.
Subcellular location: Secreted.
Interaction partners:
- Protein hugin
Sequence:
MAHTKTRRTYGFLMVLLILGSACGNLVASGSAGSPPSNEPGGGGLSEQVVLDQLSESDLYGNNKRAWQSLQSSWGKRSSSGDVSDPDIYMTGHFVPLVITDGTNTIDWDTFERLASGQSAQQQQQQPLQQQSQSGEDFDDLAGEPDVEKRAWKSMNVAWGKRRQAQGWNKFRGAWGKREPTWNNLKGMWGKRDQWQKLHGGWGKRSQLPSN
Protein: Metabotropic glutamate receptor 8 (mGluR8) (P47743)
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Metabotropic glutamate receptor 7
- Metabotropic glutamate receptor 4
- Glutamate receptor 1
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 2B
- Metabotropic glutamate receptor 2
- Glutamate receptor 2
- Glutamate receptor ionotropic, NMDA 3A
- Guanine nucleotide-binding protein subunit alpha-12
Sequence:
MVCEGKRSTSCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRLDGDIILGGLFPVHAKGERGVPCGDLKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKELCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
Protein: 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) (Q8BQB2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVSTLRLFSMFLMSSTNCSFL
Protein: MARVEL domain-containing protein (G8BJD2)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Sphingolipid long chain base-responsive protein LSP1
Sequence:
MLAIGDVILRAFNFVFLAIALGLTGSLAATTVYQHNPQINFAVFAAAFGLLTSSIYGVLAFFIEALAWPLILFIFDFLNFVFTFAAACAIAAGIRVHSCGNQDYLDSNKINQGSSGRCRKAQASTAFLFFSAFIFIASGIFSAIGLFKGGLFGSKYSRSAPRTGVPTMSQV
Protein: Protein-lysine N-methyltransferase EEF2KMT (EC 2.1.1.-) (eEF2-lysine methyltransferase) (eEF2-KMT) (Q96G04)
Organism: Homo sapiens (Human)
Function: Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23349634}.
Interaction partners:
- Elongation factor 2
- EEF1A lysine methyltransferase 2
- Phosphoribosyltransferase domain-containing protein 1
- Protein N-lysine methyltransferase METTL21D
Sequence:
MAPEENAGTELLLQSFERRFLAARTLRSFPWQSLEAKLRDSSDSELLRDILHKTVKHPVCVKHPPSVKYARCFLSELIKKHEAVHTEPLDELYEALAETLMAKESTQGHRSYLLPSGGSVTLSESTAIISYGTTGLVTWDAALYLAEWAIENPAVFTNRTVLELGSGAGLTGLAICKMCRPRAYIFSDCHSRVLEQLRGNVLLNGLSLEADITAKLDSPRVTVAQLDWDVATVHQLSAFQPDVVIAADVLYCPEAIMSLVGVLRRLAACREHQRAPEVYVAFTVRNPETCQLFTTELGRAGIRWEVEPRHEQKLFPYEEHLEMAMLNLTL
Protein: NAD(P) transhydrogenase subunit alpha part 2 (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase subunit alpha 2) (Proton-translocating transhydrogenase component 2) (Pyridine nucleotide transhydrogenase subunit alpha 2) (dII) (Q2RSB3)
Organism: Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)
Function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.
Subcellular location: Cell inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- NAD
- NAD
- NAD kinase
- Glutamine-dependent NAD
- Alanine dehydrogenase
- NAD-dependent protein deacylase
- Probable nicotinate-nucleotide adenylyltransferase
- Nucleoside triphosphate pyrophosphohydrolase
- NAD
Sequence:
MEDKNILVEGFNQLSQQALELSQHAQALALQASHAVLPAAAATEGASEFWWLMTVFVLACFIGFYVVWSVTPALHSPLMGVTNAISSVIVVGALIATGPEAFSASKVLGFFAILLASVNIFGGFIVTQRMLAMFKKKQK
Protein: Transmembrane protein 176B (Protein LR8) (Q3YBM2)
Organism: Homo sapiens (Human)
Function: May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).
Subcellular location: Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Transmembrane protein 176A
Sequence:
MTQNTVIVNGVAMASRPSQPTHVNVHIHQESALTQLLKAGGSLKKFLFHPGDTVPSTARIGYEQLALGVTQILLGVVSCVLGVCLSLGPWTVLSASGCAFWAGSVVIAAGAGAIVHEKHPGKLAGYISSLLTLAGFATAMAAVVLCVNSFIWQTEPFLYIDTVCDRSDPVFPTTGYRWMRRSQENQWQKEECRAYMQMLRKLFTAIRALFLAVCVLKVIVSLVSLGVGLRNLCGQSSQPLNEEGSEKRLLGENSVPPSPSREQTSTAIVL
Protein: Homeobox protein SEBOX (Homeobox OG-9) (Skin-, embryo-, brain- and oocyte-specific homeobox) (P70368)
Organism: Mus musculus (Mouse)
Function: Probable transcription factor involved in the control of specification of mesoderm and endoderm.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MASPVEASPGCASGLGPHRRKRTTFSVGQLVELERVFAARPYPDISTREHLAQVTHLPEAKIQVWFQNRRAKRIKDRKPGALNSRLELPPNSCSLPDTPQLPWDPGTSSHPLHPTSSAQYTSACPPQTSCLGPILGPGQSWSGAKVAAPWGTSGASGIHSSLEQIVPQTSLGNLSDLIYTSAIVTNVDHF
Protein: Magnetosome-associated protein MamJ (V6F519)
Organism: Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)
Function: Required for assembly of magnetosome chains. Regulates the dynamic behavior of MamK filaments (By similarity). May connect magnetosomes to MamK filaments (Probable). Moves from the cell poles towards midcell; movement does not depend on the treadmilling ability of MamK, suggesting MamJ associates and disassociates continuously from the MamK filament.
Subcellular location: Magnetosome {ECO:0000269|PubMed:14766587}. Note=Tagged protein extends from one pole to the other, and is longer than the magnetosome chain (PubMed:16299495). Correct subcellular location requires MamK (PubMed:20487281). {ECO:0000269|PubMed:16299495, ECO:0000269|PubMed:20487281}.
Interaction partners:
- Actin-like protein MamK
- Magnetosome formation protease MamE
- Magnetosome protein MamB
- Cell shape-determining protein MreB
- Liposome tubulation protein MamY
- Magnetite biomineralization protein Mms6
- Cell division protein FtsZ
- Magnetosome protein MamC
- FtsZ-like protein
- Magnetosome protein MamI
Sequence:
MAKNRRDRGTDLPGDGDQKISTGPEIVSVTVHPSPNLAAAAKPVQGDIWASLLESSPWSANQGGLVETAQPPSAPIRSQDPVPVADLVNRWSQPIWRTAPLAGNAESSEEGVVAPSLTQSDSVLAVSDLVIDVQPETDAEVEVSIEPEPALVEPVIEIEAEAAEVEPEPAPVADLVNRWAQPIWRTAPLAGNAESSEEGVVAPSLTQSDSVLAVSDLVIDVQPEANAEVEVSIEPEPALVEPVIEIEAEAAEVEPEPAPVEPVIEIEAEAAEVEPEPAPVEPVIEIEAEAAEVEPEPAPVEPAIEIEAIRVELEPVLIDEVVELVTEFEYSQAESVASADLIANPAPAESSRLAELLDEAAAIAAPAVAVAVEATRQPNKITASVKKRAPVQEVPVEDLLGGIFGVAGSAVRGVFTIGGGFVDGVVKGGRLVGSNVVAGTRRLAQTIEVSCGSCSSPKCDAEDKNK
Protein: Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) (A8C984)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Kinase that phosphorylates MYL2 in vitro (By similarity). Increases cardiomyocyte contractility (By similarity). Required for sarcomere formation in the developing heart.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Calmodulin
- Calmodulin-like protein 4
- Protein kinase C
- Protein kinase C
- Calmodulin-like 4b.
- Cardiac myosin light chain-1.
- Myosin regulatory light chain 2b
- Myosin regulatory light chain 2, skeletal muscle isoform A
- Myosin, light chain 4, alkali
- Myosin light chain 2 Mlc2a
Sequence:
MGTSLYRSTLLSTGGFSVSDYIRKFTKNKPDVNNIQPNVGFCHQSTQTSQQVKEVISAELELQQPEVTLPNDPSSQHSPEAHTGASEPLKPVSAGESSKALQKAKEISVKSSEPTHVQTFAPAVHLEQIDVHNVPKQETNSLVAAPADAKCVIETMTKVEKDIALQQERALERADDSHVANKVFLKSIIPGQQLEKIEDPQQQAEVSLFVDEDSLEKSVPGQHLDKKMEVLQKQAKDLPVVDEDSLNLSAPGQRQLEEKVDVPEKAEKKIDEAHKKMEEVPRKDELCIEKPVIRHAGIKTQHEETMGMETTVPKHDESKCPTETYVEKTENKNADVTLESDKIMICAVSPQNTSLDEDEKSKAAPLRKVESTLLIIDDSPPLPAPFDHRIVSAKQVPINSYYAVNPVEVLGGGRFGQVHKCAELSSGLTLAAKIIKVRGMKERDEVKNEIGVMNQLNHVNLIQLYDAFESRTNLTLIMEYVEGGELFERIIDESYQLTELDAIVFTRQICEGVQYLHQQYILHLDLKPENILCVNSTGNQIKIIDFGLARKYRPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVITYMLLSGLSPFMGDNDAETMNNILHAKWEFDTEAFENVSEEAKDFISSLLVSAKCSRLSASGCMKHSWLNNLEDKAKMYKVRLKSQMMLQRYLVAHRQWKKHFYAVAAANRLKRFQQSRSISTPN
Protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit) (O75380)
Organism: Homo sapiens (Human)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH-ubiquinone oxidoreductase chain 5
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- Acyl carrier protein, mitochondrial
Sequence:
MAAAMTFCRLLNRCGEAARSLPLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVNENFAIDLIAEQPVSEVETRVIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFRQHHH
Protein: Adiponectin receptor protein 1 (Q38A43)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MISSRFRGENVSSASTTITTNGGDQSEKTCSSSSSMRATEAPVPYNSNPDLPLYTVDQVPPHLAENLYIHTGYRMNYSAGMCFRSVLALHNETFNVWTHLIGFVIFLIVSFVFSIGVLIPRLTDRPGEGSETGGSSFPDTVSLLGFHWPTLSIFAVYSVSCLMCMLCSAAFHTLIPHNHPVIYRIAHTLDYFGITFLVVGSFLPMCYFCFACKPHLRYIYLIMVSLFGVGGLVGPCFRRWTDPAYMCAKITFYVCMVGSGLLPVFHIYLTLPSSATASVVQGLLLMMGLYGVGVMIYALKVPESLYPGEFDIYLSSHQLWHVFVLCAAVVHFFNCASMYINFDKMALNC
Protein: Serine proteinase stubble (EC 3.4.21.-) (Protein stubble-stubbloid) [Cleaved into: Serine proteinase stubble non-catalytic chain; Serine proteinase stubble catalytic chain] (Q05319)
Organism: Drosophila melanogaster (Fruit fly)
Function: Hormone dependent protease required for epithelial morphogenesis, including the formation of bristles, legs, and wings. Has a dual function, detaches imaginal disk cells from extracellular matrices through its extracellular proteolytic domain and transmits an outside-to-inside signal to its intracellular domain to modify the cytoskeleton during morphogenesis.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
Sequence:
MKQPTLIRPRLRHRRSTPAAATKMCPKRHWLVNNRAAGSRGSGGAAARSRRSLDQIVEVLVALIVVNCLATAAAALITPPDSLESLGSLGIPSSSASSSEDDDDMSSGFYRIPHRLEGYPQLQQLQRGQNFKISPKPCSFGRVEGTCMFVWECIKSEGKHVGMCVDSFMFGSCCTHNYTDNIVLPQTAFSYTRPTKPLTLRPRPPAAPYKPMISGMTTIERPHGAGTLVIRPSGPHHQGTLARPHPPPYQSKPTTASDLHGSASHPSSSSSSSSSSNPNSIWHTSTQQQQQQQHQQNQQNHWQMTTEPSFITKPRPTGWTKPGIVNLPMPARPSKPSKPTKKPIVYDRTPPPPPSVPPSTSTSTTSTSLIWPAQTHPPQPHRPTRPQLSPGTSLAASSSSHWPSSTTSTTSSTTSTTTTTTTTRRTTTPTTTTRRTTTNKPTRPYQRPTTATSSSSTSTTSSKTPTTTRPISSSSSSSSGIVTSSQRPTQPTHRTPVLATSGIETNEISDSSIPDAGALGHVKTISAARSECGVPTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCVDDLLISQIRIRVGEYDFSHVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETDSLLIGMNATVTGWGRLSEGGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWILEHVR
Protein: Placental growth hormone (Q95205)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
FTLLCLLWTQVVGAFPAMSLSRLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTSKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDVTPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
Protein: Jagunal-like protein (Q9FHN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
Sequence:
MQQRKPTAGRPSGTDGSDFSYRMVVDSRYTKVTKEKARLRPLIFVQAAIYVIGLSCAFLTTTKKDEKNTLAIAAAVAGLVCSLIGELGCRRSRVNLLRLYTAASTIVMVLSVFCAVRSRLTMEERNSSGTTAKLELAGFICAQLGAVVQILAIIVTGSLVNNMSPPTKAA
Protein: At4g21445 (Receptor-interacting protein) (Q8W1B3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Trimethylguanosine synthase
Sequence:
MNIAIHNYRHSKFIVNPHIDKTFARTRQARSNNITFMTSTHGRRRTMGLCLVRASAETGEEESDDQNKPERRSFLSLAEAGLVEISGLGAHEKFLCRLTISSLNLLRVISEQEGCSIEELNAGKICDWFLKDKLKREHNIESAVLQWDDPDFPF
Protein: Uncharacterized protein, isoform C (A0A0S0WGR0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Peroxin 11
- Peroxin-19
Sequence:
MTSTQSDQISQFLECHGTTPVPNSGTSEILKFVPSAKVVGSALSCESATKTFGVSQAHLCTTGNMVLSKPLYSLFGTYLEQLFNHPVRTKSITACVLATSANVTSQRLAGAKTLNQQSVFAYGLFGLIFGGSVPHYFYTTVERLFSQDVRFRRFFLFLSERLVYAPIYQALSLFFLALFEGKSPSTALKNVEKLYWPLLKANWQYLSVFVYLNFAYVPPMFRSISMAIISFIWVVYIAQKRRRFQDKLAAKEAAK
Protein: Chromodomain helicase DNA binding protein 1 like (A0A0A0MRH8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MERAGATSRGGQAPGFLLRLHTEGRAEAARVQEQDLRQWGLTVVFSLLLTGTPIQNSLQELYSLLSFVEPDLFSKEEVGDFIQRYQDIEKESESASELHKLLQPFLLRRVKAEVATELPKKTEVVIYHGMSALQKKYYKAILMKDLDAFENETAKKVKLQNILSQLRKCVDHPYLFDGVEPEPFEVGDHLTEASGKLHLLDKLLAFLYSGGHRVLLFSQMTQMLDILQDYMDYRGYSYERVDGSVRGEERHLAIKNFGQQPIFVFLLSTRAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMIIEGGHFTLGAQKPAADADLQLSEILKFGLDKLLASEGSTMDEIDLESILGETKDGQWVSDALPAAEGGSRDQEEGKNHMYLFEGKDYSKEPSKEDRKSFEQLVNLQKTLLEKASQEGRSLRNKGSVLIPGLVEGSTKRKRVLSPEELEDRQKKRQEAAAKRRRLIEEKKRQKEEAEHKKKMAWWESNNYQSFCLPSEESEPEDLENGEESSAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGRGGLFTALEKRSAEPRKIYELAGKMKDLSLGGVLLFPVDDKESRNKGQDLLALIVAQHRDRSNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLIRKHLAARGIPTYIYYFPRSKSAVLHSQSSSSSSRQLVP