wanglab/gogpt-training-data huggingface dataset:
Protein: Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] (P68135)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Tropomyosin alpha-1 chain
- Troponin T, cardiac muscle
- Tropomyosin beta chain
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin light chain 4
- Tropomyosin alpha-3 chain
- Tropomyosin 4
- Myosin heavy chain 13
- Myosin light chain 1/3, skeletal muscle isoform
- Profilin-4
Sequence:
MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
Protein: Late embryogenesis abundant protein (LEA) family protein (F4J573)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Late embryogenesis abundant protein
- AT3g24470/MXP5_4
- Ankyrin repeat/KH domain protein
- F-box protein At3g03040
- Late embryogenesis abundant protein At3g53040
- von willebrand factor A domain protein
- Late embryogenesis abundant protein 18
- Late embryogenesis abundant protein 29
- Oleosin
- At2g23110
Sequence:
MGLERKVYGLVMVSLVLMAIATMCCVQATIEEEAAKDESWTDWAKEKIGLKHEDNIQPTHTTTTVQDDAWRASQKAEDAKEAAKRKAEEAVGAAKEKAGSAYETAKSKVEEGLASVKDKASQSYDSAGQVKDDVSHKSKQVKDSLSGDENDESWTGWAKEKIGIKNEDINSPNLGETVSEKAKEAKEAAKRKAGDAKEKLAETVETAKEKASDMTSAAKEKAEKLKEEAERESKSAKEKIKESYETAKSKADETLESAKDKASQSYDSAARKSEEAKDTVSHKSKRVKESLTDDDAEL
Protein: PDZ and LIM domain protein Zasp (G5EFG1)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MERVTVRMARSDRRTPWGFGVTEAPDGAVLIVNVIGGSLADRAGLRNGDVVDRLEDLDNLDINAVDRLLVTAHEKIELIVTRQPSGAATRIWRPEVTENTGPGQDQTPYRVNLQHSSDTRPPQGFNNSALPFETDQRVKHMQYNSPLGIYSDKSAAEQYVQQTQGLGDNSGARAAAQRQDEPAYLRSETLRLLKEQEHGSAGGAGTTLSNHPNPSGLPVCFMCTRPILGVMARAAGKNLHGDCLSCATCGNSLRNVGHHFIEDKFYCDIHGTQRKHGGRPGMDPNIFVKSSPTAAQPVHIQDSPRAAYHPQVNTARPVSVSPAPSAGSKTVTTHYHTPKTQGILSPGQRGVPTAAFGADLSKSVTYGGGVGPGGTHYDSNRLSPAPSQYSTQSRNQSQQHYQQHVVQAPPPVPSNPPPSNDTTAEDSRNFLASRLGQVMIDENKKAGGSNGSSQHHNQQGSSYTKTSFERTTTETRPQQNTGAPRAGDFRGTGHLTTTTTTQQNGGRAPFCESCKQQIRGAFVLATGKSWCPEHFVCANSSCRRRLLECGFVEEDGQKFCESCFEQHIAPRCNKCSKPIISDCLNALQKKWHPTCFTCAHCQKPFGNSAFYLEQGLPYCEQDWNALFTTKCVSCRYPIEAGDRWVEALGNAFHSNCFTCARCNHNLEGESFFAKNGQPFCRLHA
Protein: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (FP) (Q00711)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11502169}; Peripheral membrane protein {ECO:0000269|PubMed:11502169}; Matrix side {ECO:0000269|PubMed:11502169}.
Interaction partners:
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase assembly factor 2, mitochondrial
- Succinate dehydrogenase cytochrome b subunit
- Fumarate hydratase, mitochondrial
- Mitochondrial inner membrane protein SHH3
- Succinate--CoA ligase subunit alpha, mitochondrial
- Mitochondrial inner membrane protein SHH4
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate dehydrogenase assembly factor 1, mitochondrial
Sequence:
MLSLKKSALSKLTLLRNTRTFTSSALVRQTQGSVNGSASRSADGKYHIIDHEYDCVVIGAGGAGLRAAFGLAEAGYKTACISKLFPTRSHTVAAQGGINAALGNMHKDNWKWHMYDTVKGSDWLGDQDSIHYMTREAPKSIIELEHYGVPFSRTENGKIYQRAFGGQTKEYGKGAQAYRTCAVADRTGHALLHTLYGQALRHDTHFFIEYFALDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTIIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLQDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPTAKDLACRDVVSRAITMEIREGRGVGKKKDHMYLQLSHLPPEVLKERLPGISETAAIFAGVDVTKEPIPIIPTVHYNMGGIPTKWNGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVAHTVADTLQPGLPHKPLPSDLGKESIANLDKLRNANGSRSTAEIRMNMKQTMQKDVSVFRTQSSLDEGVRNITAVEKTFDDVKTTDRSMIWNSDLVETLELQNLLTCASQTAVSAANRKESRGAHAREDYPNRDDEHWMKHTLSWQKDVAAPVTLKYRRVIDHTLDEKECPSVPPTVRAY
Protein: Uncharacterized protein Rv0647c (P9WQI1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable lipase/esterase LipG
- Mycolic acid methyltransferase MmaA1
Sequence:
MRAEIGPDFRPHYTFGDAYPASERAHVNWELSAPVWHTAQMGSTTHREVAKLDRVPLPVEAARVAATGWQVTRTAVRFIGRLPRKGPWQQKVIKELPQTFADLGPTYVKFGQIIASSPGAFGESLSREFRGLLDRVPPAKTDEVHKLFVEELGDEPARLFASFEEEPFASASIAQVHYATLRSGEEVVVKIQRPGIRRRVAADLQILKRFAQTVELAKLGRRLSAQDVVADFADNLAEELDFRLEAQSMEAWVSHLHASPLGKNIRVPQVHWDFTTERVLTMERVHGIRIDNAAAIRKAGFDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVLMGAVGTMKPETQAAKDLERFATPLTMQSLGDMSYADIGRQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPRWQMMSDPQLTGYFANFMVEVSREHQSDIEV
Protein: Piercer of microtubule wall 2 protein (H3BRN8)
Organism: Homo sapiens (Human)
Function: Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:V9GXK1}.
Interaction partners:
- Cilia- and flagella-associated protein 53
- Piercer of microtubule wall 1 protein
- EF-hand domain-containing family member C2
- Cilia- and flagella-associated protein 161
- Tektin-3
- EF-hand domain-containing protein 1
- Ciliary microtubule inner protein 2B
- Tektin-1
- Meiosis-specific nuclear structural protein 1
- Tektin-4
Sequence:
MTDRNRDKKSTSPSNSDTEMKSEQLPPCVNPGNPVFSCMLDPKTLQTATSLSKPQMIMYKTNSSHYGEFLPIPQFFPCNYTPKEQVFSSHIRATGFYQNNTLNTAPDRTRTLDFPNIQHTL
Protein: Phospho-furanose lactonase (EC 3.1.1.104) (EC 3.1.1.25) (Q4A724)
Organism: Mycoplasmopsis synoviae (strain 53) (Mycoplasma synoviae)
Function: Catalyzes the hydrolysis of D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate. Also able to hydrolyze carboxy 1,4-lactones.
Interaction partners:
- Ascorbate-specific PTS system EIIC component
Sequence:
MENKFARTVLGDIPVEKLGITDCHDHFIKNGGPEVEEHIDFLMLNVDASIKEFKEFIDRGGSTIVTMDPPNVGRDVLKTLEIANAVKNLGGNVIMSTGFHKAKFYDKYSSWLAVVPTEEIVKMCVAEIEEGMDEYNYNGPVVKRSKAKAGIIKAGTGYGAIDRLELKALEVAARTSILTGCPILVHTQLGTMALEVAKHLIGFGANPDKIQISHLNKNPDKYYYEKVIKETGVTLCFDGPDRVKYYPDSLLAENIKYLVDKGLQKHITLSLDAGRILYQRNYGLTKGKQTFGLAYLFDRFLPLLKQVGVSKEAIFDILVNNPKRVLAFDEKRNFDPLKVSKEVLELKKELNLN
Protein: Putative uncharacterized protein YCL002C (P25565)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLVIVLQGLAGFLSIIAILCQKRYNKLHRSIYGLSYDLFLLDFVGNGLYLYCALHYCYSSLVREQLSQRFPLFYPLNDARSIPISSFLILKDFCVSCCCMMVLRQLYYYRSTKHIYQGISITSIIIISVFLVLGIFTYGCSISNLPLKNSGKFGVFYLEHINYLWVMANLLKCFKYVPQMSINWMGCSTVGLSSKFALISFLAESIDLLGRLVIPTNALFYEIPFNSTPFWVKLIQFVTLLVILCQVQYVYVGRKPRLPKGKL
Protein: 2-oxoglutarate-dependent dioxygenase AOP3 (EC 1.14.11.-) (Q9ZTA1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: 2-oxoglutarate-dependent dioxygenase involved in glucosinolates biosynthesis. Catalyzes the conversion of methylsulfinylalkyl glucosinolates to hydroxyalkyl glucosinolates (By similarity).
Interaction partners:
- Methylthioalkylmalate synthase 1, chloroplastic
- Methylthioalkylmalate synthase 3, chloroplastic
- Probable 2-oxoacid dependent dioxygenase
- Flavin-containing monooxygenase FMO GS-OX1
- Cytochrome P450 83A1
- Transcription factor MYB28
- Transcription factor MYB76
- Dihomomethionine N-hydroxylase
- Methionine aminotransferase BCAT4
- Transcription factor MYB29
Sequence:
MGSCSPQLPLICLSDQTLKPGSSKWVKVRSDVRKALEDYGCFEAKIDQVSMELQGSVLKAMQELFALPTEAKQRNVCPKPFTGYLSHNGLSESFGIKDANILEKAHEFTQQLWPEGNKSISKMIQLYAEKLAELDMMVRRLILESYGIEYFIDEHLNSTYYRMRLMKYIARPDNDITAAVGANVDNGANDNADGDANVNDDGASIGVKVNVDVGDDVNDNDSVNIGVGVDINVETNVNGDLDAEANGDATAWVVGAVSGNASVGAKEANVDAELGLPSHTDKSLTGIIYQHQIDGLEVKTKEGKWIRVKPAPNTVIVIAGDALCALMNGRIPSPYHRVRVTEKKKTRYAAALFSNPKEGYIIDSPKELVDEKHPRAFKPFDFVDLFNFYHTEAGRRAPSTLQAFCGVSAGK
Protein: Rifin (Q8IM80)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKLLYSKILLFALALNILLTSYYAHNKNKPYIIPRYTPTATSRVLSECDIHAPIYYNDEDMKSVKENFERQTSRRFEEYNERMNKNRQKCKEQRDKDIQKIILKDKIEKSLEEKVEKGCLRCACGLGGVAAGVGIIGAIAVNEWTKVATAAAVQKGIKAGIAKAIDDLGNIVGLIQFDLIDWAAKIDGINFLKQNSLVSIVNEVYYKCIDIENSSDFLFCSATKAWDQQKSTLGLQIISNQAAEAAVAAGKAAETAEKAEIVLVNAKSSLLYSAIGYSVIAILIIVLVMIIIYLILRYRRTKKMNKKAEYTKLLNK
Protein: Insulin (A3RID6)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU000406}.
Interaction partners:
Sequence:
MAYWLQAASLLVLLALSPGADAAAAQHLCGSHLVDALYLVCGEKGFFYNPKRDVDPLIGFLSPKSAKENEEYPFKDQMEMMVKRGIVEQCCHKPCNIFDLQNYCN
Protein: Plays structural role in maturation of all 3 hydrogenases (Q8X814)
Organism: Escherichia coli O157:H7
Interaction partners:
Sequence:
MQQLINSLFMEAFANPWLAEQEDQARLDLAQLVAEGDRLAFSTDSYVIDPLFFPGGNIGKLAICGTANDVAVSGAIPRYLSCGFILEEGLPMETLKAVVTSMAETARTAGIAIVTGDTKVVQRGAADKLFINTAGMGAIPTNIHWGAQTLTAGDILLVSGTLGDHGATILNLREQLGLDGELVSDCAVLTPLIQTLRDIPGVKALRDATRGGVNAVVHEXAAACGCGIEISESALPVKPAVRGVCELLGLDALNFANEGKLVIAVERNAAEQVLAALHSHPLGKDAALIGEVVERKGVRLAGLYGVKRTLDLPHAEPLPRIC
Protein: ESAT-6-like protein (A0A0H3L852)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MTINYQFGDVDAHGAMIRAQAGLLEAEHQAIIRDVLTASDFWGGAGSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA
Protein: T. brucei spp.-specific protein (Q388Q6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVVTSERLTLHKCVHLKSPRISFSIPKRVRKAQGKDLYFGYFQLFVCRSCFRRFIASVASRLWAGSCGWAPNTFFFLQLQCLHLGYNYFPFPWFLRNHSFRGGICSYIYIYMCVCVCAQLLSFSPLVNPPCYVVPYFLCFTYTPVSSIFCSVSGRE
Protein: Terminal uridylyltransferase cid1 (TUTase cid1) (EC 2.7.7.19) (EC 2.7.7.52) (Caffeine-induced death protein 1) (Poly(A) polymerase cid1) (PAP) (Poly(U) polymerase cid1) (PUP) (O13833)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Cytoplasmic uridylyltransferase that mediates the terminal uridylation of mRNAs with short poly(A) tails such as such as act1, hcn1 and urg1 mRNAs, hence facilitating global mRNA decay. Uridylates the 3' ends of actin mRNAs upon S-phase arrest. Has also a weak poly(A) polymerase (PAP) activity. Residue His-336 is responsible for the specificity for UTP. Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12218190}.
Interaction partners:
- DIS3-like exonuclease 2
- Coatomer subunit delta
- Poly
- Putative purine nucleoside phosphorylase
- LSM1-LSM7 complex subunit lsm1
- 3'-5' exonuclease eri1
- mRNA cleavage and polyadenylation specificity factor complex subunit pta1
- Protein MIX23
Sequence:
MNISSAQFIPGVHTVEEIEAEIHKNLHISKSCSYQKVPNSHKEFTKFCYEVYNEIKISDKEFKEKRAALDTLRLCLKRISPDAELVAFGSLESGLALKNSDMDLCVLMDSRVQSDTIALQFYEELIAEGFEGKFLQRARIPIIKLTSDTKNGFGASFQCDIGFNNRLAIHNTLLLSSYTKLDARLKPMVLLVKHWAKRKQINSPYFGTLSSYGYVLMVLYYLIHVIKPPVFPNLLLSPLKQEKIVDGFDVGFDDKLEDIPPSQNYSSLGSLLHGFFRFYAYKFEPREKVVTFRRPDGYLTKQEKGWTSATEHTGSADQIIKDRYILAIEDPFEISHNVGRTVSSSGLYRIRGEFMAASRLLNSRSYPIPYDSLFEEAPIPPRRQKKTDEQSNKKLLNETDGDNSE
Protein: Aspartyl protease AED1 (EC 3.4.23.-) (Apoplastic EDS1-dependent protein 1) (Q9LEW3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aspartyl protease involved in a homeostatic feedback mechanism regulating systemic immunity. Has only mild or no influence on local defenses. Acts downstream of salicylic acid to suppress systemic immunity.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:24755512}.
Interaction partners:
- Ankyrin repeat family protein
- Glucan endo-1,3-beta-glucosidase, acidic isoform
- Protein EDS1
- AAA-ATPase At3g28510
- Serine rich endogenous peptide 7
- Endochitinase CHI
- Receptor like protein 23
- EG45-like domain containing protein 2
- Uncharacterized protein At1g23150
- Subtilisin-like protease SBT3.3
Sequence:
MSIMRNFLSMIIMLCVCLNWCFAEGAEKSDSGKVLDSYTIQVSSLFPSSSSCVPSSKASNTKSSLRVVHMHGACSHLSSDARVDHDEIIRRDQARVESIYSKLSKNSANEVSEAKSTELPAKSGITLGSGNYIVTIGIGTPKHDLSLVFDTGSDLTWTQCEPCLGSCYSQKEPKFNPSSSSTYQNVSCSSPMCEDAESCSASNCVYSIVYGDKSFTQGFLAKEKFTLTNSDVLEDVYFGCGENNQGLFDGVAGLLGLGPGKLSLPAQTTTTYNNIFSYCLPSFTSNSTGHLTFGSAGISESVKFTPISSFPSAFNYGIDIIGISVGDKELAITPNSFSTEGAIIDSGTVFTRLPTKVYAELRSVFKEKMSSYKSTSGYGLFDTCYDFTGLDTVTYPTIAFSFAGSTVVELDGSGISLPIKISQVCLAFAGNDDLPAIFGNVQQTTLDVVYDVAGGRVGFAPNGC
Protein: DNA-directed RNA polymerase I subunit rpa34 (RNA polymerase I subunit A34) (Q9USZ4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (By similarity).
Subcellular location: Nucleus, nucleolus.
Interaction partners:
- DNA-directed RNA polymerase I subunit rpa49
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerase I subunit rpa43
- DNA-directed RNA polymerase I subunit rpa14
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I and III subunit RPAC1
- UPF0653 protein C607.02c
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Probable DNA-directed RNA polymerase I subunit RPA2
- DNA-directed RNA polymerase I subunit rpa1
Sequence:
MAKSSEFVNEESSEDESSVSSIEDQHSSKEPEQSVESNNHGESNAQEDVAEIAGLEKVQGKPVLTTNDLKKESNVFLVRLPPGMSADQISQLKVGSKPTVELKQENENTYQIREESTSSVRVFLPDEQGSYTSNEIKTGYVITETPKISQNIDTGITIPTQAPLVPQRKNLRQHFRPIGDAVGPESEPEAEPKSGIKEHILQETGDATVEELQNKGKEKQKELKKGKREKKDEEEKPKKKKQKKSSKKEKN
Protein: Olfactory receptor 13C3 (Olfactory receptor OR9-8) (Q8NGS6)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MIVQLICTVCFLAVNTFHVRSSFDFLKADDMGEINQTLVSEFLLLGLSGYPKIEIVYFALILVMYLVILIGNGVLIIASIFDSHFHTPMYFFLGNLSFLDICYTSSSVPSTLVSLISKKRNISFSGCAVQMFFGFAMGSTECLLLGMMAFDRYVAICNPLRYPIILSKVAYVLMASVSWLSGGINSAVQTLLAMRLPFCGNNIINHFACEILAVLKLACADISLNIITMVISNMAFLVLPLMVIFFSYMFILYTILQMNSATGRRKAFSTCSAHLTVVIIFYGTIFFMYAKPKSQDLIGEEKLQALDKLISLFYGVVTPMLNPILYSLRNKDVKAAVKYLLNKKPIH
Protein: Chitin synthase regulator 2 (J9VSG5)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Function: Activator of the chitin synthase CHS3 which polymerizes chitin, a structural polymer of the fungal cell wall. Chitin produced by CHS3 is deacetylated to chitosan, which helps to maintain cell wall integrity, anchor melanin, and offers an advantage during infection, as chitosan is less readily detected by host immunosurveillance.
Subcellular location: Cell membrane {ECO:0000305|PubMed:16278457}; Lipid-anchor {ECO:0000250|UniProtKB:P34226}; Cytoplasmic side {ECO:0000250|UniProtKB:P34226}. Note=Farnesylation is not required for cellular membrane localization. {ECO:0000250|UniProtKB:P34226}.
Interaction partners:
Sequence:
MATTNAQIYQQSQMPIPMPTPSLNPNINSAPTPGPNAMSVYEDCQSPLDTSVSGMYPGDRGSRVVSQPAPLLDQSHLRPGNQANLLSHDRTIELYRENAKKTNDPELIFEFSAFMIDAAKAMIPPEQEKDTNPSPALIKQMEKREEIIKEATSLLKRLADRGFPDAQYFLADCYANGIGTARGKQDFDRAFPLFILAAKHGHPDACYRAGTCCEHGWGCRRDSAKAVSFYKKAAVGLHPGAMYRLGTAELNGALGFPRRPKEGVKWLKRSAEHATEEFPHALHELALLHERGIENVVFVDNDYAAELLAQSAELGYAPSAFKLGECYEYGKMGCPVDPALSIHYYNISAQQDHKDACFALTAWYLVGSPGVLPQSDTEAYLWAKKAAELGLAKAQYAVGYFTETGIGIEANPQAALTWYKQAAEGGDKRAAKRLATGSRSSALDRRLEMEALKEEKRLGAANLAQRSGSGSGASGKDGKDGCLIM
Protein: ATP synthase subunit epsilon-like protein, mitochondrial (ATP synthase F1 subunit epsilon pseudogene 2) (Q5VTU8)
Organism: Homo sapiens (Human)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P56381}.
Interaction partners:
Sequence:
MVAYWRQAGLSYIRYSQICAKVVRDALKTEFKANAKKTSGNSVKIVKVKKE
Protein: Xaa-Pro aminopeptidase app-1 (EC 3.4.11.9) (Aminopeptidase P) (O44750)
Organism: Caenorhabditis elegans
Function: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Has activity towards the flp-9 neuropeptide KPSFVRF-amide.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11606206}.
Interaction partners:
- Protein pid-4
- Zinc metalloproteinase nas-28
- Protein pid-2
Sequence:
MTALEKLAKLRSLFHSERVLALTSSKPMVAYLLPSTDAHHSEYLADYDFRVKFLSGFSGSNAYVVVTDREALLWTDGRYFTQAGNQLDSNSWKLMKQGQPDSITVVDWLVRELERGSVIGFDPTLSTFDAGSKTFKRLKAAGLQPVSIPGNLVDEFWTDRPRLAGEPVVVLDVEDTGLTTSKKVENLREKLKQKKCDAAVFTLLDDVMWLLNIRGSDIPYNPLAYSYLFVAMREIHVFIDNEKLDEKSRAHFHKSNVSIHPYGEVYSWISNWLKAKEASKEPHMVYLTPETNYAIGSIIGEENSMVDTSLVQTAKATKNDHEMQGMRNSHLRDSAALVEFLCWLEKELLSGKRYTEIELADKIDHLRSLQDKYVTLSFDTISAVGDHAALPHYKPLGESGNRKAAANQVFLLDSGAHYGDGTTDVTRTVWYTNPPKEFILHNTLVLKGHINLARAKFPDGIYGSRLDTLTRDALWKLGLDFEHGTGHGVGHYLNVHEGPIGIGHRSVPTGGELHASQVLTIEPGFYAKEKYGIRIENCYETVEAVVMSKAQNFLTFKSLTLVPIQTSIVDKSLLIEEEINWLNQYHARVLKEVGEHLQKRGKTDELKWLAEACKPI
Protein: Protein jagunal (Q7K1V5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for endoplasmic reticulum organization and proper vesicular traffic during vitellogenesis. Required for oocyte and bristle growth.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17389229}; Multi-pass membrane protein {ECO:0000269|PubMed:17389229}.
Interaction partners:
- RE64534p
Sequence:
MATRGGPMVAGTDGNDFEFRQRVAGTYQISLLNKSRLKYCIFFHALLFFVMLAKLTSDILDHLDIFVLEIEELEVPPPLWWEYVWAASLLTSFLGLSAARGNKVREMQKYMVAILLFAILPLFYCFAYYFSDVWEFATLDKSVELDETDIFVWRGYPYGVFWYAFCFVGFQVHGFTLYFAYNLVKAWKARTATRKFQ
Protein: Meiotically up-regulated gene 191 protein (O14131)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative mannan endo-1,6-alpha-mannosidase C970.02
- Autophagy-related protein 17
- Autophagy protein 13
- Uncharacterized protein C4.03c
Sequence:
MSENVYLNEALNVVDQCFKTFFDKYTDRMGSAFACSGTIDKDHIFLVWSVAVYAEAMADSLRYTSKFERKFEHVFQALKKYWSPVFNACCAFHYFEGNDDVYYDDNAQVAIGLATAGYYTTNSSRRDHYVSRAESIISLIINKGWNQQRGGIAWHTRTTGPPWTNLNACSTSMSAVAALRLALALDDPNKKQHLVSFAWNCVRWIQENLLDENHIVCDGLSLKDGKWVLDKARFTYNTGTTMTAMSLLMGLGEFTKGLQDIEKLPTYLEDMARGALDTNGPLYDQSCNGSFKVWSDNTFFAQHLSEGLMTFSYAMPSSALAKPAQKMVLDQADFLMKYLRIPKEGLYYRNFGLYKLSPELTASFNKFFNANKQFQPDKDERIQQEGPVEQRPLCPTLIGSAGAARMLFSAAEIVNRNNPSSGESTTLPQPSHGKKDKDCVIS
Protein: Universal stress protein PHOS34 (Phosphorylated protein of 34 kDa) (AtPHOS34) (Q8L4N1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Transducin/WD40 repeat-like superfamily protein
- HSP20-like chaperones superfamily protein
- Protein BOBBER 2
- Tetratricopeptide repeat protein SKI3
- Adenine nucleotide alpha hydrolases-like superfamily protein
- Mitogen-activated protein kinase 6
Sequence:
MNPDSDYPHLPNIKIHHPSSPRHSHHHSSSTPSAATPTPTAGARRKIGVAVDLSEESAFAVRWAVDHYIRPGDAVVILHVSPTSVLFGADWGPLPLQTPPPPSAATDPGAQPKPSQEDFDAFTSSKVADLAKPLKEAGFPHKIHIVKDHDMRERLCLETERLNLSAVIMGSRGFGAEKRGSDGKLGSVSDYCVHHCVCPVVVVRYPDDRDGPAPPGNVGATREAIVTVKSRRDDDDDDDEDHEAKIAAAASDHHEHIKDE
Protein: Uncharacterized protein YfhG (P0AD44)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Transcriptional regulatory protein GlrR
- Sensor histidine kinase GlrK
- Nitrogen regulatory protein P-II 1
Sequence:
MRHIFQRLLPRRLWLAGLPCLALLGCVQNHNKPAIDTPAEEKIPVYQLADYLSTECSDIWALQGKSTETNPLYWLRAMDCADRLMPAQSRQQARQYDDGSWQNTFKQGILLADAKITPYERRQLVARIEALSTEIPAQVRPLYQLWRDGQALQLQLAEERQRYSKLQQSSDSELDTLRQQHHVLQQQLELTTRKLENLTDIERQLSTRKPAGNFSPDTPHESEKPAPSTHEVTPDEP
Protein: Cytochrome b561 domain-containing protein (O16271)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Uncharacterized protein T25D10.1
- F-box domain-containing protein
- F-box domain-containing protein
- CUB-like domain-containing protein
- CUB_2 domain-containing protein
- ShKT domain-containing protein
- CUB_2 domain-containing protein
- C-type lectin domain-containing protein
- C-type lectin domain-containing protein
- Cysteine-rich protein 1
Sequence:
MSSDSRLGNARSFNRFDIILSITHFVGFITICLNGYFLNTFKNGLAWPSKVKNGDNKALGKRGDQLHAFLMILAFIYFQGEALLAYRLYRYDAKIISKLLHTALHIIAIGLGITALTVIIMSTNNAGWNNFTSVHSWIGICLLSVYLVQFSFGFLTYLCPCSPGKYRARLMPIHRAVGVGCFIVACVQCCLGYGNILLEDQPGCFSDLSCKNRIEYVGAFSVMFIILYTLLVLALIIPVPWRREKTPDELK