wanglab/gogpt-training-data huggingface dataset:
Protein: PHD finger protein 12 (PHD factor 1) (Pf1) (Q5SPL2)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mortality factor 4-like protein 1
- Paired amphipathic helix protein Sin3a
- Paired amphipathic helix protein Sin3b
- Histone deacetylase 1
- AT-rich interactive domain-containing protein 4B
- AT-rich interactive domain-containing protein 4A
- GATA zinc finger domain-containing protein 1
- Sin3 histone deacetylase corepressor complex component SDS3
- Histone-binding protein RBBP7
- Histone-binding protein RBBP4
Sequence:
MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKESRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDKSSKRTTSPSSDTDLLDRPASKTELKAIAHARILERRASRPGTPTSNASTETPTSEHNDVDEDIVDVDEEPVAAEPDYVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKRTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNLTLSNRCQVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRVLQSVKRRSLKVPDAIKSQYQFPPPLIAPAAIRDGELICSGVPEESQTHLLNSEHLATQAEQQEWLCSVVALQCSILKHLSAKQMPSPWDSEQTEKADIKPVIVTDSSITTSLQTADKAPLPSHYPLSCPSAVSTQNSLGCSPPHQPPTLEDISCSSCVEKSKKAPCGTANGPVNTEIKANGPHLYSSPTDSTDPRRLPGANTPLPGLTHRQGWPRPLTPPSAGGLQNHVGIIVKTENATGPSSCPQRSLVPVPSLPPSIPSSCASIENTSTLHRKTVQSQIGPSSTESRPLGSPPNATRVLTPPQAAGDSILATGANQRFCSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLDEKLIKFLALQRVHQLFPSRVQASPGNVGTHPLASGGHHPEVQRKEVQARAVFCPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGDASLLQDGVLAEKLSLKPHQGPVLRSNSVP
Protein: Poly (ADP-ribose) polymerase family, member 6 (A0A8I5ZUL8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILYMFTSQQWKHLSNDLLKTQQEKRHSWFKASGSIRKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRVPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRQLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFQ
Protein: Ras-related protein Rab-11A (P36412)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Required for normal contractile vacuole structure and function. Cells expressing a dominant negative rab11A exhibit a more extensive contractile vacuole network and enlarged contractile vacuole bladders. These cells exhibit a functional defect in osmotic regulation where cells immersed in water become rounded and detach from the surface, and contain swollen contractile vacuoles.
Subcellular location: Contractile vacuole membrane {ECO:0000269|PubMed:11686306}; Lipid-anchor {ECO:0000269|PubMed:11686306}; Cytoplasmic side {ECO:0000269|PubMed:11686306}.
Interaction partners:
- Ras-related protein Rab-11C
- Ras-related protein Rab-11B
- Exocyst complex component 6
- Rab GDP dissociation inhibitor
- Rac guanine nucleotide exchange factor B
- Uncharacterized protein
- Drainin
- RabGAP/TBC domain-containing protein
Sequence:
MTSKGSQEEYDYLYKIVLIGDSGVGKSNLLSRFTRNEFSLETKSTIGVEFATRTIQTEGKTIKAQVWDTAGQERYRAITSAYYRGAVGALLVYDIAKQATYKSVERWILELRENADRNIEIMLVGNKSDLRHLREVSTDEAKEFSEKHKLTFIETSALDSSNVELAFQNILTQIYHIMSRPSHSTGPQTTIDSNTETIILPTTSEPPAAKSGCC
Protein: Ribosomal protein P2B (Q5ANH5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Large ribosomal subunit protein uL3
- 60S acidic ribosomal protein P0
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL37
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL38
Sequence:
MKYLAAYLLLVQGGNTSPSASDITALLESVGVEAEESRLQALLKDLEGKDLQELIAEGNTKLASVPSGGAAAGGASASAGAAAGGAAEAEEEKEEEAKEESDDDMGFGLFD
Protein: Lymphocyte antigen 6K (Ly-6K) (Q17RY6)
Organism: Homo sapiens (Human)
Function: Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth.
Subcellular location: Secreted {ECO:0000269|PubMed:18089789}. Cytoplasm {ECO:0000269|PubMed:18089789}. Cell membrane {ECO:0000250|UniProtKB:Q9CWP4}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9CWP4}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9CWP4}. Membrane raft {ECO:0000250|UniProtKB:Q9CWP4}.
Interaction partners:
- Testis-expressed protein 101
- Ly6/PLAUR domain-containing protein 2
- Ly-6/neurotoxin-like protein 1
- Lymphocyte antigen 6H
- Secreted Ly-6/uPAR-related protein 1
- Kinetochore protein Nuf2
- DEP domain-containing protein 1A
Sequence:
MALLALLLVVALPRVWTDANLTARQRDPEDSQRTDEGDNRVWCHVCERENTFECQNPRRCKWTEPYCVIAAVKIFPRFFMVAKQCSAGCAAMERPKPEEKRFLLEEPMPFFYLKCCKIRYCNLEGPPINSSVFKEYAGSMGESCGGLWLAILLLLASIAAGLSLS
Protein: Splicing factor U2AF-associated protein 2 (Cold sensitive U2 snRNA suppressor 2 homolog) (O43120)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in pre-mRNA splicing.
Interaction partners:
- U2 snRNP component prp10
- Pre-mRNA-splicing factor sap145
- Pre-mRNA-splicing factor sap114
- Spliceosome-associated protein 49
- Pre-mRNA-splicing factor sap62
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor cwf4
- Pre-mRNA-splicing factor prp12
- Pre-mRNA-processing ATP-dependent RNA helicase prp11
- Small nuclear ribonucleoprotein F
Sequence:
MSSQPFWDERIHRWRCLGSEGNELIYIDEEQTWKDYDPNSLKMNKAGSTGAEVSDVTAEATEGKESSNGEDRHTKRLYESTSAEGYPSGSRNKKSKSENSEASPAPVINKAVYIQGLPLDVTVDEIEEVFKKCGVIAKNIDNGTPRIKIYRTEDGTPKGDALIVFFRSESVELAEQLFDDTEFRYGSGQKMRVQKANIDYKKEKTVNKDVGGALKKKALRLRQQQMQQISSWDDVDEEVDDKRKKRFNKIVVLKHIFTLEELDKTPELLIDLKDDITEEAEKCGRVTNVVLYDKEPDGVVTVRFSNNEEAEACVRLMQGRYFDGRVVEASIYDGKVRFQKSGKHTLDDEEDEEKRLEKFADWLENSN
Protein: Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-) (Q80V03)
Organism: Mus musculus (Mouse)
Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized aarF domain-containing protein kinase 2
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- F-box/LRR-repeat protein 6
Sequence:
MWRPMRLCHFHSTLLQSRQKPWPCPAIFFRRNFKSPPARTSRARLLWRRALSATVVGTPFLLGAYYFMAEASERRKLRLAVDGIGRFGRSVKIGLFISTDYWWCTNVVLRGVEENSPKYVEIMSACHQRAADALVAGAIRNGGLYVKLGQGLCSFNHLLPTEYIQTLRVLEDKALTRGFREVDELFLEDFQALPNELFQEFDYEPMAAASLAQVHRAKLHDGTDVAVKVQYIDLRDRFDGDVQTLELLLRLVELMHPSFGFSWVLQDLKGTLVQELDFENEGRNAERCAQELKHFHYVVIPRVHWDRSSKRVLTADFCNGCKVNDMEGIKSQGLAVQDVAKKLIQTFAEQIFHTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLDEKDRSSLCQLWRAIILRDNAAMKKHAAALGVQDYMLFSEVLMQRPVRLGQLWGSHLISREEAAYMQDMAREHFDGIMEVLKALPRPMLLVLRNINTVRAINSNLGTPVDRYFLMAKSAVWGWSRLVGAAYQGIYGSSLLRHIKVLWEALKFEMALRLEILAMRLTALMLRVLVRLGFAPKAEAEEVYQYLEM
Protein: Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) (A0A8I6AB19)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
KTSVLLQVYAGRVYYFNHITNASQWERPSGGSTVGGGSKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRSKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (H6TS39)
Organism: Zea mays (Maize)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSFVFRGSRADIEAGGFTGFAPERRTMRIHAGSRPVNSNSLVFLLTVFVLFMVLNSHQMSPNLLLWIVLGVFLMATSLRMYATCQQLAHAAAANSFLGHTELRVHVPPTIALATRGQLQSLRLQLALLDREFDDLDYDTLRALDADNSLHVPSMSEEEINSLPVFKYKVQAQQGNAPARKSDEASQLSVSSTGSSNEKKQDGLKADGTGKTTQDELTCSVCLEQVMVGDLLRSLPCLHQFHVNCIDPWLRQQGTCPICKHQVSDGWHATGNGEEDASYMV
Protein: Probable clathrin heavy chain 1 (P34574)
Organism: Caenorhabditis elegans
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Cytoplasmic face of coated pits and vesicles. {ECO:0000250}.
Interaction partners:
- Clathrin light chain
- Auxilin
- AP complex subunit beta
- ENTH domain-containing protein
- Amphiphysin
- Dynamin
- AP-2 complex subunit mu
- Beta-arrestin arr-1
- AP-2 complex subunit alpha
- AP-1 complex subunit gamma
Sequence:
MALPIKFHEHLQLPNAGIRVPNITFSNVTMESDKNIVVREMIGDQQQVVIIDLADTANPTRRPISADSVIMHPTAKILALKSGKTLQIFNIELKAKVKAHQNVEDVVYWKWISEKTIALVSDTAVYHWSIEGDAAPVKMFDRHQSLAGTQIINYRADAENKWLVLIGISAKDSRVVGSMQLYSTERKVSQPIEGHAACFVRFKVDGNQNPSNLFCFSVKTDNGGKLHVIEVGTPAAGNTPFQKKNVDVPYTADTAGDFPVSMQVSAKQGIIYLVTKQGYVHLYDVESGTRIYSNRISTDTVFVTCEYTATGGIMGINRKGQVLSVSIDEANLVPFVTNQLQNPDLALKLAVRCDLPGAEELFVRKFNLLFSNGQFGESAKVAASAPQGILRTPATIQKFQQCPSTGPGPSPLLQYFGILLDQGKLNKYETLELCRPVLAQGRKELITKWLNDQKLECCEELGDLIKPHDVNTALSVYLRGNVPHKVVQSFAETGQFDKIVMYAKRVGFQPDYLFQLRQILRNSNPDHGAKFAQLLVSESENGEPLADLSQIIDCFMEVQAVQPCTSFLLEVLKGDKPEEGHLQTRLLEMNLLAAPAVADAILANKMFSHYDRAAIGQLCEKAGLLQRALEHFTDLYDIKRTVVHTHLLKPDWLVGYFGSLSVEDSVECLKAMLTQNIRQNLQVVVQIASKYHEQLGADKLIEMFENHKSYEGLFYFLGSIVNFSQDPEVHFKYIQAATRTGQIKEVERICRESQCYDAERVKNFLKEAKLNDQLPLIIVCDRHNMVHDLVLYLYRNQLQKYIEVFVQKVNAARLPIVVGALLDVDCSEDAIKQLIINTRGKFDIDELVEEVEKRNRLKLLNHWLESKIQEGATDAATHNAMAKIYIDSNNNPERFLKENPYYDSKVVGKYCEKRDPHYAFLSYERGQCDAELINVCNENSLFKNLARYLVKRRDFTLWEQVLNEENVHRRQLIDQVVQTALSETQDPEDISVTVKAFMAADLPNELIELLEKIVLDNSAFSEHRNLQNLLILTAMRADRTRVMEYIQKLDNYDAPDIANIAITSELYEEAFAIFKKFDVNSSAINVLIENVNNLDRAYEFAEKCNQSDVWASLAKAQLQQNLVKEAVDSFIKADDPGAYMEVVNKCSQTEHWEDLVRYLQMARKKSRESYIETELVFALAKTGRLTELEEFIAGPNHAQIGQIGDRCFDNGMFDSAKILFNNVSNFAKLSVTLVRLGEYQGAVDAARKANSTKTWKQVCFSCVENGEFRLAQMCGLHIVVHADELEELINFYQDRGHFEELIALLEAALGLERAHMGMFTELAILYSKYKPEKMREHLELFWSRVNIPKVLRAAEQAHLWSELVFLYDKYEEYDNAALTMMQHPTESWREQHFKEVIAKVANVELYYKAMQFYLDYKPLLLNDLLTVLSPRLDHSRTVLFFNKLKQIPLVKPYLRQVQNLNNKAINEALNQLLIDEEDHAGLRSSIEAQDNFDNITLAQQLEKHPLVEFRRISAYLFKGNNRWKQSIELCKKDKLYKDAMEYAAESRNGELAEELLSFFLDEKLYDCFAASLYHCYDLLHPDVIMELAWKHKIMDYAMPYMIQVMRDYQTRLEKLERSEHERKEEKAEQQQNNGMTMEPQLMLTYGAPAPQMTYPGTTGGYGGQPAYGQPGQPGYNAPGFM
Protein: U3 small nucleolar RNA-associated protein 15 (U3 snoRNA-associated protein 15) (U3 protein 15 required for transcription) (O94365)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable U3 small nucleolar RNA-associated protein 7
- U3 small nucleolar RNA-associated protein 4
- Uncharacterized WD repeat-containing protein C2E1P5.05
- 13 kDa ribonucleoprotein-associated protein
- U3 small nucleolar RNA-associated protein 10
- U3 small nucleolar RNA-associated protein 17
- Probable U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 21 homolog
- Nucleolar protein 58
- Uncharacterized WD repeat-containing protein C3D6.12
Sequence:
MSAPAGRLQPQRFAALPNPVTAENKFWRSFKVPVVAKEYSAITSIHFSAESPYDFAVTSGARVQIYGASSRSVKKTIARFKDTAYSGNIRKDGKLLLAGDATGLVQIFDLSTRSILRALDAHQFPVHVTQFCPYANTTFLSGSDDKTVKVWDLSTGAVQYDLSGHEDYVRTASWMSATRLVSGGYDGTIRLWDTRIADPEVMSFSHGEAIDVVLPMQSGSTVISAGGPSIKVWDLVAGRQTPTKKLSNHQKSITCLAMNSENTRLLSGGLDGHVKIYNISDWKVVHGMKYSGPILSMGLSPDSCNLVVGMSNGTLSQRTRRITKQTSSKTPFLGGVGSAFGVVGKKKQIYKGENDEFYVEEARRKRLRPFDKALKSFCYSDALDMVLENGSPVLIITMLIELLHVGGLRIALSNRDDLSLTPLINFLRKYIRDPRFSETLCIVTSTILDIYGAALGGSVMVENAISKLREKVEQEVAVTQRANELVGMLQMLSA
Protein: UDP-glucuronosyltransferase 1-2 (UDPGT 1-2) (UGT1*2) (UGT1-02) (UGT1.2) (EC 2.4.1.17) (B2) (Bilirubin-specific UDPGT) (UDP-glucuronosyltransferase 1A2) (UGT1A2) (P20720)
Organism: Rattus norvegicus (Rat)
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Subcellular location: Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDTGLCAPLRGLSGLLLLLCALPWAEGGKVLVFPMEGSHWLSMRDVVRELHARGHQAVVLAPEVTVHMKGEDFFTLQTYAFPYTKEEYQREILGNAKKGFEPQHFVKTFFETMASIKKFFDLYANSCAALLHNKTLIQQLNSSSFDVVLTDPVFPCGALLAKYLQIPAVFFLRSVPCGIDYEATQCPKPSSYIPNLLTMLSDHMTFLQRVKNMLYPLTLKYICHLSITPYESLASELLQREMSLVEVLSHASVWLFRGDFVFDYPRPIMPNMVFIGGINCVIKKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTLLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH
Protein: Uncharacterized protein (Q8C1D2)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGLVSFEDVAVDFTWQEWQELDAAQRTLNRDVMLENYSSLVSLGHCVTKPELILRLEHGFQPWSIGDTSVWRLPGVLEVYTPNESCLENAESRMWPVGSINRNLSNKEMIEAEMKVQLELPRGTKPYECKPCMKMVSLPSQCSKQHAYYPSVKPYEWKECQKAFCYKSALTQHQRARTRLKIYQCTECKKAFSSKSELTVHHRIHTGEKPHACEECGKAFYRKSTLTVHQKTHRGEKPYECKECWKAFYYKSTLTEHQRIHTGEKPYVCKDCGKAFFYKSNLTRHHRTHTREKPYECKECRKGFSSKSELTSHHRTHTGEKPYQCEECGKAFYCKSTLRVHQKIHSGEKPYECKECQKSFYYKSTLTEHQRTHTGEKPYECKELWQGFLLQVTVNSPS
Protein: Transcriptional corepressor LEUNIG (F4JUD2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSQTNWEADKMLDVYIHDYLVKRDLKATAQAFQAEGKVSSDPVAIDAPGGFLFEWWSVFWDIFIARTNEKHSEVAASYIETQMIKAREQQLQQSQHPQVSQQQQQQQQQQIQMQQLLLQRAQQQQQQQQQQHHHHQQQQQQQQQQQQQQQQQQQQHQNQPPSQQQQQQSTPQHQQQPTPQQQPQRRDGSHLANGSANGLVGNNSEPVMRQNPGSGSSLASKAYEERVKMPTQRESLDEAAMKRFGDNVGQLLDPSHASILKSAAASGQPAGQVLHSTSGGMSPQVQTRNQQLPGSAVDIKSEINPVLTPRTAVPEGSLIGIPGRFAVLSVSFQLVKRVKCSISTSAHKNLLRINDWFPVSGSNQGSNNLTLKGWPLTGFDQLRSGLLQQQKPFMQSQSFHQLNMLTPQHQQQLMLAQQNLNSQSVSEENRRLKMLLNNRSMTLGKDGLGSSVGDVLPNVGSSLQPGGSLLPRGDTDMLLKLKMALLQQQQQNQQQGGGNPPQPQPQPQPLNQLALTNPQPQSSNHSIHQQEKLGGGGSITMDGSISNSFRGNEQVLKNQSGRKRKQPVSSSGPANSSGTANTAGPSPSSAPSTPSTHTPGDVISMPNLPHSGGSSKSMMMFGTEGTGTLTSPSNQLADMDRFVEDGSLDDNVESFLSQEDGDQRDAVTRCMDVSKGFTFTEVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWDADNKGYSLRTFMGHSSMVTSLDFHPIKDDLICSCDNDNEIRYWSINNGSCTRVYKGGSTQIRFQPRVGKYLAASSANLVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSEDMVKVWTLGTGSEGECVHELSCNGNKFQSCVFHPAYPSLLVIGCYQSLELWNMSENKTMTLPAHEGLITSLAVSTATGLVASASHDKLVKLWK
Protein: Csp2p (A0A1D8PL45)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
- Cell wall mannoprotein PIR1-like C-terminal domain-containing protein
- Cell wall mannoprotein PIR1-like C-terminal domain-containing protein
Sequence:
MKFSTAALTLSLFAIVNSSVTTYGAGFGGDDDDNSKHHKYDCEIDTYEWKFALAVKEWKHCQDKKFCQDTDLDLVYEGDDGQLYHGCDGTYPYSKCKHCTNVFTGGDDDDDNCDDDCKKKKKKVYFAKRGDDDDDDKCDDKCEYPYCEIHNTDCDLLITLCGGVLTDDKHATGEIVANHQFQFDKPPQKDALHKKGFSIVHTEGTYYLALDHKIDFWHCKVDDKGLYKIYDKSIGEQCSKIKLIVLKSDEKATFTDDSDDCDDDCKKNKKKQHD
Protein: Extra-extra (RE39081p) (Q9VSC2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Lim3, isoform G
Sequence:
MSSAQVSQQPPPPPLTASSSTSMPSQLLLSHIQHHSSSLHHQRSHQRSSPPAQDYDQGSNQSTLSPRSQITPSPPAASPTHSAATTGSPVSTYTPALSPGGAQDSSQTESGQSSQMPLLVAPMPVGTGPPHSHPPPPHPRLYVEGFPPPHHVPHPHPALGTYPLPRLPLMLPANPPGVPSGAAAPPPVSPQPAANHLSHSGATMATTTLLPPAQSQPKKSFCIDALLAKSQHQSGEPQPIIVDDRLAALHYARDQAELNHAFVTASNAAAAAQAAASAAGGISEQEALQRIRDSREYDSPSPDGMSRSESPTSSHRSSPPISPGCEDQQQPHGALHPQHLSMRMSDFHDEFKKPIPPHSPIRPQDFPLYAGGHPYQLLAQGGSAFHRPLDPSGKPIPIPMGHNFMPSQLQFEFLARAGMLHHRIPELAAYPHHAILGKTRRPRTAFTSQQLLELEKQFKQNKYLSRPKRFEVASGLMLSETQVKIWFQNRRMKWKRSKKAQQEAKERAKANQQQQQQQQTPSAAS
Protein: Centrosomal protein of 72 kDa (Cep72) (Q9P209)
Organism: Homo sapiens (Human)
Function: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19536135}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26297806}. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.
Interaction partners:
- Pericentriolar material 1 protein
- Serine/threonine-protein kinase PLK1
- Coiled-coil domain-containing protein 14
- Centrosomal protein of 290 kDa
- HAUS augmin-like complex subunit 6
Sequence:
MARAGPRLVLSEEAVRAKSGLGPHRDLAELQSLSIPGTYQEKITHLGHSLMSLTGLKSLDLSRNSLVSLEGIQYLTALESLNLYYNCISSLAEVFRLHALTELVDVDFRLNPVVKVEPDYRLFVVHLLPKLQQLDDRPVRASERKASRLHFASEDSLDSKESVPASLKEGRPHHPRAKCTEALAKQSLVMDADDEAVLNLIAECEWDLGRPPGSTSFSQKGREADSRGSQESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLYGAEPEASRAPRPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRKRRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTLSQPEASETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFTAAQDSSAMVGEDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSVKRLCGEIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHLLQELSQVRAQHRAEVEQMHWSYQELKKTMALFPHSSASHGGCQAC
Protein: Serine-rich and transmembrane domain-containing protein 1 (A2A2V5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSEPDTSSGFSGSVENGTFLELFPTSLSTSVDPSSGHLSNVYIYVSIFLSLLAFLLLLLIIALQRLKNIISSSSSYPEYPSDAGSSFTNLEVCSISSQRSTFSNLSS
Protein: Mitochondrial sodium/calcium exchanger protein (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Sodium/potassium/calcium exchanger 6) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1) (Q6J4K2)
Organism: Homo sapiens (Human)
Function: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity. Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:23056385}; Multi-pass membrane protein {ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:23056385}.
Interaction partners:
- Mitochondrial proton/calcium exchanger protein/H
- Calcium uptake protein 1, mitochondrial
- Calcium uniporter protein, mitochondrial
- Calcium uptake protein 2, mitochondrial
- Mitochondrial calcium uniporter regulator 1
Sequence:
MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
Protein: Gamma-crystallin C (Gamma-C-crystallin) (Gamma-crystallin 2-1) (Gamma-crystallin 3) (P07315)
Organism: Homo sapiens (Human)
Function: Crystallins are the dominant structural components of the vertebrate eye lens.
Interaction partners:
- Alpha-crystallin A2
- C-C chemokine receptor type 5
- C-C chemokine receptor type 2
- C-C chemokine receptor type 1
- C-C chemokine receptor-like 2
- C-C chemokine receptor type 6
- Gap junction alpha-8 protein
- Gap junction alpha-3 protein
- Phakinin
- Alpha-crystallin B chain
Sequence:
MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
Protein: Transcription factor bHLH25 (Basic helix-loop-helix protein 25) (AtbHLH25) (bHLH 25) (Transcription factor EN 29) (bHLH transcription factor bHLH025) (Q9T072)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Acid phosphatase-like protein
Sequence:
MSILSTRWFSEQEIEENSIIQQFHMNSIVGEVQEAQYIFPHSFTTNNDPSYDDLIEMKPPKILETTYISPSSHLPPNSKPHHIHRHSSSRILSFEDYGSNDMEHEYSPTYLNSIFSPKLEAQVQPHQKSDEFNRKGTKRAQPFSRNQSNAQDHIIAERKRREKLTQRFVALSALVPGLKKMDKASVLGDALKHIKYLQERVGELEEQKKERRLESMVLVKKSKLILDDNNQSFSSSCEDGFSDLDLPEIEVRFSDEDVLIKILCEKQKGHLAKIMAEIEKLHILITNSSVLNFGPTLDITIIAKKESDFDMTLMDVVKSLRSALSNFI
Protein: Chemokine (C-C motif) receptor 2 (A0A140LFQ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- C-C motif chemokine
- Chemokine
- Chemokine
- Interleukin family protein
- Integrin, alpha M
- Stromal cell-derived factor 1
- Beta-arrestin-1
- Arrb2b protein
- Arrestin, beta 2a.
- G protein-coupled receptor kinase
Sequence:
MSATQNSSFDDYYNYNETGHVAPPCNNGNAKAFSEVFLPTLYSIVFIVGFIGNGLVVWVLIRHRQKSNMTDVCLFNLALADLIFLVSLPFWAHNAMDEWILGRFMCHTITGLFMIGLYASIFFMVLMTLDRYAIIVHAHSVFSRNRSTKMGLALASLVWMLSLFASLPNIIFANANNGTNSKSSCRPDFPDNTSWMSFTYINMNLLSLIFPLIIMSFCYSRIIPTLLSIKSQKRHKVVRLILAVVAVYFLFWTPYNIVMFLMFLQRMEYMFSCEWHNGLSLAMQWVETIALSHCCLNPIIYAFAGEKFRRAVLKVLKDQFPMCFKQCASFSQQLSERRSSIFSRSSEISSTQIA