wanglab/gogpt-training-data huggingface dataset:
Protein: T-complex protein 1 subunit beta (CCT-beta) (F5GWF6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MASLSLAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLGNVSLITTPVKHSHVLSIFGPVSSKVVFERYSIKEDCGICLSVPIISLSLDI
Protein: Fgr37p (Q5A4M9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MYGAASHSQAGHSNNCARAHNGNNKTTTTTPTTKCVSIEKIKTSHSNGHFCVISHYLYACTISMMRMIAILTGITMYNCDGEKTTKEACETKKEKCDPVCQV
Protein: Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] (P01272)
Organism: Bos taurus (Bovine)
Function: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01275}.; SUBCELLULAR LOCATION: [Glucagon-like peptide 1]: Secreted {ECO:0000250|UniProtKB:P01275}.
Interaction partners:
- Glucagon receptor
- Glucagon like peptide 1 receptor
- Dipeptidyl peptidase 4
- Appetite-regulating hormone
- Glucagon-like peptide 2 receptor
- G protein-coupled receptor 119
- Leptin
- Insulin
- Somatostatin
- Vasoactive intestinal polypeptide receptor 2
Sequence:
MKSLYFVAGLFVMLVQGSWQRSLQNTEEKSSSFPAPQTDPLGDPDQINEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVNIVEELRRRHADGSFSDEMNTVLDSLATRDFINWLLQTKITDRK
Protein: Jabba, isoform C (B7YZK5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAQETKTVATAKDQNQRDHIDEEEVIELHESRSFYDRVREQAERFASTRVGQFVIERADKALAMIEDTAKWSLPQDKSSAPLERPLPWAPFLMLIVLLRLTRIWLSVGALMIGNGPISPTDMVYFIQTRRRKLRAIRVHGLKVMRRRQQEVSYGSGKGMTQKLNQWFSRAMCRPGVQQDSSSRRVFVRHSEQGLSNFVVKRPREEDCNADADLTIDQMLAKYANENSEDDSDFVPNEEEEEEESSSSSGESESESGSSEGISSGEVDEVVSQPKQKSAGAVVENGVHKAEEKENDKGKLNITTTSNGNNDKEQADVDHPFICRPENEKFKISHQATSAAQPDEEWKSSPGHMSAAVMNTRLYNNTAAAVTTDPDPEPDTQPEPEFPSEPTSQSQPSTEETDDDAEDSCSSSGSNQTGITVYQADETQPDTQAEQILEIAATLTDSHLSNYPTVDTLTPATSSEDIFYSPIGSPTCFNTSLGTQALLKRASIQSVLAHSTPTTEMRDQPIEEANNSVPQTPETEKTQPQTPKEVHNQNQQQNQQQRQRNHPHQRYRGRNRR
Protein: Inner membrane metabolite transport protein YgcS (Q46909)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Putative electron transfer flavoprotein subunit YgcR
- Putative electron transfer flavoprotein subunit YgcQ
- Uncharacterized FAD-linked oxidoreductase YgcU
Sequence:
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIGGSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYFGPHVLLGDEVVTATHKHIKTLFSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLLAATLVVMACLPSGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQVTLLLLATVLLVGFVVTWLWAPETKALPLVAAGNVGGANEHSVSV
Protein: Probable receptor-like protein kinase At5g39020 (EC 2.7.11.-) (Q9FID6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Probable serine/threonine protein kinase IRE3
- Uncharacterized protein
- Uncharacterized protein
- Cyclase-associated protein 1
- Probable disease resistance protein At4g19530
- Disease resistance protein RPS4B
- GPI-anchored protein LLG3
- Cytochrome P450 76C3
Sequence:
MNCNVLFLLSVLVSVTAGVTAAYHPTDVFLFNCGDTSNNVDNSGRNWTVESRQILSSNLVNASFTSEASYQKAGVSRIPYMKARIFRSEFTYSFPVTPGSIFLRLYFYPTQYKSGFDAVNSFFSVKVNGFTLLRNFNADSTVQASIPLSNSLIKEFIIPVHQTLNLTFTPSKNLLAFVNGIEIVSMPDRFYSKGGFDNVLRNVSSDVDFQIDNSTAFESVHRLNVGGQIVNEVDDSGMFRRWLSDDSFGNSGSIVNVPGVKINYTEKTPAYVAPYDVYATSRLMGNSSNLMFNLTGMFLTVDAGYNYLVRLHFCETLPQVTKAGQRVFSIFVEDKMAKKETDVIRLSGGPRIPMYLDFSVYVGFESGMIQPELRLDLVPLKDTNQTYYDAILSGVEILKLNDSDGNLARPNPELLVSTDSTPDDSNVTPPIKGKPHVLVIILIVVGSVIGLATFIVIIMLLIRQMKRKKNKKENSVIMFKLLLKQYIYAELKKITKSFSHTVGKGGFGTVYRGNLSNGRTVAVKVLKDLKGNGDDFINEVTSMSQTSHVNIVSLLGFCYEGSKRAIISEFLEHGSLDQFISRNKSLTPNVTTLYGIALGIARGLEYLHYGCKTRIVHFDIKPQNILLDDNFCPKVADFGLAKLCEKRESILSLIDTRGTIGYIAPEVVSRMYGGISHKSDVYSYGMLVLDMIGARNKVETTTCNGSTAYFPDWIYKDLENGDQTWIIGDEINEEDNKIVKKMILVSLWCIRPCPSDRPPMNKVVEMIEGSLDALELPPKPSRHISTELVLESSSLSDGQEAEKQTQTLDSTII
Protein: NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314) (P26718)
Organism: Homo sapiens (Human)
Function: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}; Single-pass type II membrane protein {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST on the cell surface.
Interaction partners:
- Hematopoietic cell signal transducer
- MHC class I polypeptide-related sequence A
- MHC class I polypeptide-related sequence B
- Retinoic acid early transcript 1E
- UL16-binding protein 2
- UL16-binding protein 3
- UL16-binding protein 1
- UL-16 binding protein 5
- UL16-binding protein 6
- TYRO protein tyrosine kinase-binding protein
Sequence:
MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV
Protein: Chemokine CK-1 (Q9PT05)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MISCRACVLAALFSLLIITLIPTTQSADCCLKFTRRPVHCRWLKGYTFQDITSSCDLNAVIFQNLRNKFVCADPSQDWTKRVQRYLRKRQEKKSQLKKRV
Protein: GABA(A) receptor-associated protein b (F1QY33)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- NBR1 autophagy cargo receptor a
- Ubiquitin-like-conjugating enzyme ATG3
- NBR1 autophagy cargo receptor b
- Cysteine protease
- Cysteine protease ATG4B
- Ubiquitin-like protein ATG12
- Cysteine protease
- Autophagy protein 5
- Beclin-1
- Protein ref
Sequence:
MRRGESTAAVCEAPGYISDNTVCVCDTNLLLTATTMKFQYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGE
Protein: Solute carrier family 3 member 2a (F1QSI9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Large neutral amino acids transporter small subunit 1
- Cystine/glutamate transporter
- Cystine/glutamate transporter
- Solute carrier family 3 member 2b
- Zgc:158423.
- Y+L amino acid transporter 2
- Solute carrier family 7 member 10a
- Solute carrier family 7 member 8b.
- Solute carrier family 7 member 7.
- Amino acid transporter
Sequence:
MNKEDEMKEVELNEMDQEKQPMTGETPTGTEKNGSVKVKVPEDAEVKFTGLSKEELMKVAGTAGWVRTRWALLVLFWLGWVGMLAGAIVIIVQAPRCKPIPEMHWWNEGPLYQISNLDAFSKNGLKGVEEKLDYLSQMKVKGLVLGPVHSVQADQSSALELTSINPDFGSESELTSLLDRAHRKGISIVLDLTPNYRGVSSWFNNAASVAEKLKKACVYWLNKGVDGIFLSDLNDIVNTYAWSSIQAIFNKTDGTPKKALMGTASSLSVDETSLLLNQSGVDLLLTKLPYPAGLSGRQATLMQRLCSGHQEASLGWGLGQTAGSQASRTPALPVKLYQTLLFALPGTPVFSAGDELGLKAGEAMWEDVNSTAEEERTAVRNFFKTLSDLKGKERSLLHGEYVNLHNSPTSLAFLRLWDQSERFMVAVNWGNDSISMTPTNDDLPAEARVRATTDIEKLAVDSKVKLEKLELGSKQAVLLSYPFPG
Protein: Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) (Q8K394)
Organism: Mus musculus (Mouse)
Function: May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10581172}. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells.
Interaction partners:
Sequence:
MAECGRGAAGGALPTSPSPALGAKGALKAGAGEGGGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARTSPGRGPLGVALARTPSPAAGPVPRDSKPGGLPRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWISQMFSEIDVDGLGHITLCHAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEITKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENVEQPNHVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVNQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNNPLVVLNLSEPYPTMELQAIVPEVLKKIVTTYDMMMQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENSEAQKPRRSLEAIPEKASDENGD
Protein: histidine kinase (EC 2.7.13.3) (Q9HV74)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Alginate biosynthesis transcriptional regulatory protein AlgB
- MFS transporter
- Catabolite repression control protein
- Bifunctional protein PutA
- RNA polymerase sigma-54 factor
- histidine kinase
- histidine kinase
- DNA-binding transcriptional regulator NtrC)
- RNA-binding protein Hfq
- histidine kinase
Sequence:
MLTSFSLTQLILISVTYLSTLFGIAWITERGYVPRRLVRHPLVYTLSLGVYASAWAFYGTVGLAYQYGYGFLAIYLGISGAFLLAPVLLYPILRVTRAYQLSSLADLFAFRFRSTWAGALTTLFMLIGVLPMLALQIQAVTDSISILTRDPAQERVAFVFCTLITLFAILFGARHIATRERHEGLVFAIAFESLVKLVMLGSIGLYALYGVFGGPEGLEVWLLQNQTALTTLHTPLAEGPWRTLLLVFFAAAIVMPHMFHMIFTENLNPRALISASWGLPLFLLLMSLAVPPILWAGLRLGASTTPEYYTIGLGLAVDSPALALAAFIGGISAASGLTIVMTLALSGMVLNHLVLPLYQPPAQGNIYRWLKWTRRLLIVAIIMASYAFYLLLGAEQDLSNLGIVSFVATLQFLPGALSVLYWPTANRRGFISGLIAGMLVWAITMLLPLMGNVQGLYLPLFDVIYVLDDSNWHLAALSSLAANVLVFTLVSLFTEASDEEKGAAEACAVDNVRRPQRRELFAGSPQEFASQLAKPLGAKTAQKEVEQALRDLHLPFDERRPYALRRLRDRIEANLSGLMGPSVAQDIVETFLPYKTSEESYVTEDIHFIESRLEDYHSRLTGLAAELDTLRRYHRQTLQDLPMGVCSLAKDQEVLMWNRAIEELTGVGAQKVVGSRLSALPEPWKGLLERFIDAPDEHLHKQRLVYDGHTRWLNLHKAAIEEPLAPGNSGLVLLVEDLTETQLLEDKLVHSERLASIGRLAAGVAHEIGNPITGIACLAQNLREEREGDGELTEISEQILDQTKRVSRIVQSLMSFAHSGSHLQALEPVCLSEVAQEAIGLLSLNRRSVEVEFFNLCDPAHWVEGDSQRLAQVLINLLSNARDASPPGGAIRVRSEASEHTVDLVVEDEGSGIPKAIMDQLFEPFFTTKDPGKGTGLGLALVYSIVEEHYGQITIESPTDHQREGGTRFRVTLPRHPGPTAEL
Protein: Proteasome subunit beta type-3 (Q55D66)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-6
- Proteasome subunit beta type-2
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-7
- Proteasome subunit alpha type-2
Sequence:
MSIMAYNGGACIVMVGKNCVAIASDLRFGIQQQTISNDFPKVYRINDKCFVGISGLVTDAQTLYQKLVFRHNLYKLREERDMSPRVVSNLLTNMLYEKRFGPYFTEPLICGLEGPDNTPFISGMDLIGASVATDDFLVVGTMTPAMYGVCETLYKKDMNEDDLFETISQCMLASLDRDALSGWGAIVHVITPTQVITKKLLGRQD
Protein: DELTA-pseudomyrmecitoxin-Pp1a subunit A (DELTA-PSDTX-Pp1a subunit A) (C0HLS2)
Organism: Pseudomyrmex penetrator (Ant)
Function: This heterodimer has insecticidal and cytotoxic properties. Induces immediate paralysis when injected into blowflies (Lucilia cuprina), and then death within 24 hours. Also inhibits the growth of Aedes albopictus mosquito C6/36 cells.
Subcellular location: Secreted {ECO:0000269|PubMed:33344898}.
Interaction partners:
Sequence:
KIPNILKGGLKSICKHRKYLDKACAAI
Protein: Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UBCH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) (P62257)
Organism: Mus musculus (Mouse)
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.
Interaction partners:
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin-conjugating enzyme E2 W
- Ubiquitin-conjugating enzyme E2 J1
- Ubiquitin-conjugating enzyme E2 J2
- Ubiquitin-conjugating enzyme E2 variant 2
- 
- Tripartite motif-containing protein 72
- NEDD8-activating enzyme E1 catalytic subunit
- Ubiquitin-conjugating enzyme E2 Q1
- Ubiquitin-conjugating enzyme E2 Z
Sequence:
MSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPDKYPFKSPSIGFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHRPEEYKQKIKEYIQKYATEEALKEQEEGTGDSSSESSMSDFSEDEAQDMEL
Protein: Tubulin-specific chaperone C (Chromosome instability protein 2) (Tubulin-folding cofactor C) (P46670)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Chromosome instability protein 1
- GTP-binding protein CIN4
- Protein PAC2
- Tubulin-specific chaperone A
- Tubulin alpha-3 chain
- SWR1-complex protein 3
- Spindle assembly checkpoint component MAD1
- Mitotic spindle checkpoint component MAD2
- Tubulin-specific chaperone B
- Uncharacterized protein YIL092W
Sequence:
MDFTAKIKELERELSETSDYKTLQKKTISLRSELNTLSHSLTSYEKEHFSNDIENVLKSINAKLSESKGKKRLFSFKQKNSSSAVHKNVERTELANAPAYTTTLKKHYVLEKGDSAFENLEFCTVTSTTDYSGNSALSGSLCFRNITKCVINLQRIFFQTGSIFITDCTDSIIFLRSPSDKDFQIRLRDLKNCKILIEKLSPSIDCKQVVIIENCHKCIFNASTRDHLIIQDFSNPFQSEETEDNSAFAFEDFDICNKDTMQLFRAYL
Protein: Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (Receptor-interacting protein 2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) (P58801)
Organism: Mus musculus (Mouse)
Function: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is release from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Also plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. Plays a role in the inactivation of RHOA in response to NGFR signaling.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O43353}. Cell membrane {ECO:0000250|UniProtKB:O43353}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43353}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O43353}. Note=Recruited to the cell membrane by NOD2 following stimulation by bacterial peptidoglycans. {ECO:0000250|UniProtKB:O43353}.
Interaction partners:
- Nucleotide-binding oligomerization domain-containing protein 2
- Nucleotide-binding oligomerization domain-containing protein 1
- E3 ubiquitin-protein ligase XIAP
- TNF receptor-associated factor 3
- TNF receptor-associated factor 6
- Caspase recruitment domain family, member 6
- TNF receptor-associated factor 2
- Tumor necrosis factor receptor superfamily member 16
- NF-kappa-B essential modulator
- Caspase recruitment domain-containing protein 9
Sequence:
MNGDAICSALPPIPYHKLADLHYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSERNDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTSEENLPFDIPHRGLMISLIQSGWAQNPDERPSFLKCLIELEPVLRTFEDITFLEAVIQLKKAKIQSSSSTIHLCDKKMDLSLNIPANHPPQEESCGSSLLSRNTGSPGPSRSLSAPQDKGFLSGAPQDCSSLKAHHCPGNHSWDGIVSVPPGAAFCDRRASSCSLAVISPFLVEKGSERPPIGIAQQWIQSKREAIVSQMTEACLNQSLDALLSRDLIMKEDYELISTKPTRTSKVRQLLDTSDIQGEEFAKVVVQKLKDNKQLGLQPYPEVPVLSKAPPSNFPQNKSL
Protein: Anion/proton exchange transporter GEF1 (CLC protein GEF1) (ClC-A) (ClC-Y1) (Voltage-gated chloride channel) [Cleaved into: GEF1 N-terminal; GEF1 C-terminal] (P37020)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Anion/proton exchange transporter involved in iron and copper cation homeostasis. Involved in intracellular iron metabolism during growth on fermentable and non fermentable carbon sources. Required for proper copper-loading and maturation of multicopper oxidase FET3. Important for adjusting intracellular compartment pH to more alkaline pH under iron limitation. May also transport chloride ions through the plasma membrane.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:9614122}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000305|PubMed:9520490}; Multi-pass membrane protein {ECO:0000255}. Prevacuolar compartment membrane {ECO:0000269|PubMed:12074596}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Copper-transporting ATPase
Sequence:
MPTTYVPINQPIGDGEDVIDTNRFTNIPETQNFDQFVTIDKIAEENRPLSVDSDREFLNSKYRHYREVIWDRAKTFITLSSTAIVIGCIAGFLQVFTETLVNWKTGHCQRNWLLNKSFCCNGVVNEVTSTSNLLLKRQEFECEAQGLWIAWKGHVSPFIIFMLLSVLFALISTLLVKYVAPMATGSGISEIKVWVSGFEYNKEFLGFLTLVIKSVALPLAISSGLSVGKEGPSVHYATCCGYLLTKWLLRDTLTYSSQYEYITAASGAGVAVAFGAPIGGVLFGLEEIASANRFNSSTLWKSYYVALVAITTLKYIDPFRNGRVILFNVTYDRDWKVQEIPIFIALGIFGGLYGKYISKWNINFIHFRKMYLSSWPVQEVLFLATLTALISYFNEFLKLDMTESMGILFHECVKNDNTSTFSHRLCQLDENTHAFEFLKIFTSLCFATVIRALLVVVSYGARVPAGIFVPSMAVGATFGRAVSLLVERFISGPSVITPGAYAFLGAAATLSGITNLTLTVVVIMFELTGAFMYIIPLMIVVAITRIILSTSGISGGIADQMIMVNGFPYLEDEQDEEEEETLEKYTAEQLMSSKLITINETIYLSELESLLYDSASEYSVHGFPITKDEDKFEKEKRCIGYVLKRHLASKIMMQSVNSTKAQTTLVYFNKSNEELGHRENCIGFKDIMNESPISVKKAVPVTLLFRMFKELGCKTIIVEESGILKGLVTAKDILRFKRIKYREVHGAKFTYNEALDRRCWSVIHFIIKRFTTNRNGNVI
Protein: Kinase (EC 2.7.-.-) (Q8MRX9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAKSDQELPEGFRQLKTQVAGHTFEESNAEAVGLLQDSKAGCVLKPLGKPECGERELRFYESLAEAGASGDNDLLALLRGHVPRFYGPLKLVVNRRERTFLRLEDLTRSYAKPCVMDVKMGKRTWDPESSPNKRKVEEAKYVICKQKLGLCLPGFQVYLPKEEHTQETTILRHGKDYGKSLNVEGFKQTMALFFNASTSDSKSRRAGCELLLKEVLRQLQEILAWFQRQRLLHFYASSLLICYDYSRLADPPKPLINGYHQNDDDPATWVRVKMIDFAHVYPAEQGLPDENYMFGLQSLIEVVQSILHR
Protein: Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] (P09533)
Organism: Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Function: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
Subcellular location: [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}.; SUBCELLULAR LOCATION: [Transforming growth factor beta-1]: Secreted {ECO:0000250|UniProtKB:P01137}.
Interaction partners:
Sequence:
MPPSGLRLLPLLLPLLWLLVLTPSRPAAGLSTCKTIDMELVKRKRIETIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSNSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSKDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
Protein: 7TM GPCR serpentine receptor class x (Srx) domain-containing protein (O02071)
Organism: Caenorhabditis elegans
Interaction partners:
- RING-type domain-containing protein
- PUD1_2 domain-containing protein
Sequence:
MSLSNWTLEQIWIEDSRPEDIATPLMTITAGVFMIIASAFGIFINILVLHRFIAKNMSSFYLMCSSKTVSNSIILFCYLIFNGPVSVGRSYYGPEFMNMLLNQMAAYGIYVQGPMTQVCISFNRFMVIYFVSLAKRKSGRLATITALCTCWTISFIVTIAGIPKNCTNIFNYEILTWDNLDPCVDILADAVMYWIGFLAIISNTFNVVVAVKLIVSASKPHMDSTASKRRKRTSRNLFLQSCFQDWVYLIDTINSMYIYSWFSDILWQFFFTIFSNLMVHVTDGCIMLFFNYEGKKKTLTLTLNNVKREVTVLTVTF
Protein: Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I) (Q91VS7)
Organism: Mus musculus (Mouse)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P08011}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P08011}.
Interaction partners:
- Rhotekin
- Cell division control protein 42 homolog
- Hematopoietic prostaglandin D synthase
- Glutathione S-transferase Mu 1
- Glutathione S-transferase theta-1
- Glutathione S-transferase 3, mitochondrial
- Glutathione S-transferase A3
- Microsomal glutathione S-transferase 2
- Glutathione S-transferase Mu 7
- Glutathione S-transferase A4
Sequence:
MADLRQLMDNEVLMAFTSYATIILTKMMFMSSATAFQRITNKVFANPEDCAGFGKGENAKKFVRTDEKVERVRRAHLNDLENIVPFLGIGLLYSLSGPDLSTALMHFRIFVGARIYHTIAYLTPLPQPNRGLAFFVGYGVTLSMAYRLLRSRLYL
Protein: GTPase-activating protein GYP8 (P43570)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- GTP-binding protein YPT1
- GTPase-activating protein GYP7
- GTPase-activating protein GYP5
- GTPase-activating protein GYP6
- GTPase-activating protein GYP1
- GTPase-activating protein GYP2
Sequence:
MPLRSLFHTNQSSHDKDALTRGGYNAYLESLSRCDSGKAEEQKGKVISKLLEKKDVRALRYIGLGPLGFVNNSLRKDCWYELLASQLLIDDATEYITPVEKHKDEGQVILDAERSFGGIVDKNLKLQLRKLLVELITRVLRKYPTLNYYQGYHDIVSVFIMCFSWNVTKENGLELENLSLQEEIDMERLFYCIEAFTLLYLRDFMMNSLDFSFEQLRVISSLIKESNMKFYNLFKFDENEPLFAIGSILTIFAHNLKPIDSGDNNLHKILFQIFDMTISMQSMRLPLIIYKNLLLQNASEISKQIEANSDFFENDFDLRHGAIQTVLQKKLYDEALWEEVLQITRKDATTASKKALKRVSLNKYSALLNTACGKPGCFDMSTIIFYLSEQTKMNEHYKEEKYHGVAARSKTRALVQRLGHFLPSKYNRWSKISLLIGIVAILYQLRTTRSLSLVLNLRYMISTKLKDLSHININLHHVSHIWVDPIRDILKLGHPTR