wanglab/gogpt-training-data huggingface dataset:
Protein: Protein adenylyltransferase FICD (EC 2.7.7.108) (AMPylator FICD) (De-AMPylase FICD) (EC 3.1.4.-) (FIC domain-containing protein) (Huntingtin yeast partner E) (Huntingtin-interacting protein 13) (HIP-13) (Huntingtin-interacting protein E) (Q9BVA6)
Organism: Homo sapiens (Human)
Function: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP. In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25601083, ECO:0000269|PubMed:36136088}; Single-pass type II membrane protein {ECO:0000305|PubMed:25601083}.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
- Huntingtin
- Microtubule-associated protein 1 light chain 3 alpha
- Pre-mRNA-processing factor 40 homolog B
Sequence:
MMLIPMASVMAVTEPKWVSVWSRFLWVTLLSMVLGSLLALLLPLGAVEEQCLAVLKGLYLLRSKPDRAQHAATKCTSPSTELSITSRGATLLVAKTKASPAGKLEARAALNQALEMKRQGKREKAQKLFMHALKMDPDFVDALTEFGIFSEEDKDIIQADYLYTRALTISPYHEKALVNRDRTLPLVEEIDQRYFSIIDSKVKKVMSIPKGNSALRRVMEETYYHHIYHTVAIEGNTLTLSEIRHILETRYAVPGKSLEEQNEVIGMHAAMKYINTTLVSRIGSVTISDVLEIHRRVLGYVDPVEAGRFRTTQVLVGHHIPPHPQDVEKQMQEFVQWLNSEEAMNLHPVEFAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITIRKEQRSDYYHVLEAANEGDVRPFIRFIAKCTETTLDTLLFATTEYSVALPEAQPNHSGFKETLPVKP
Protein: C2H2-like zinc finger protein (Putative C2H2-type zinc finger protein) (Q9ZQE0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein indeterminate-domain 11
- Zinc finger
- Protein indeterminate-domain 7
- Protein indeterminate-domain 12
- Zinc finger protein WIP6
- At4g35700
- Zinc finger protein WIP2
- Protein SENSITIVE TO PROTON RHIZOTOXICITY 2
- Zinc finger protein BALDIBIS
- Polyadenylation and cleavage factor homolog 4
Sequence:
MSSMPNKFNPHCDDNNRGFSSIQMNQNSQMVHSRFITSDHTNHGDLFSSSPSFSCFHNSHASSSSFGFQNSHVENHMMKRNIISDDNYFSITNNPHFTRVSFTQTITNKFTAIVPTNTLDAVQYDAQRVKRAMNPKTNIWNPIFSPPNTFDKQCEFLNPKPLNVIFPSQNSAYPQHLDMFSLSSKHNHDQRVLQDGRSMKKILKPTIFFEATTDYIESQENEKSNNDHNDGRTHSLPYEKYGPYTCPKCNGVFNTSQKFAAHMSSHYKNETSEEREQRIRAKNKRKFCKLNREINGEPQKTKQEDVANNSEKSDDKTFQHLVVVKEELV
Protein: Forkhead box C1 (W6CJ52)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MQARYSVSSPNSLGVVPYLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPGGMARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKDRLHLKEPPPPGRQPPPAPPEQADGNAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAAAVPKIESPDSSSSSLSSGSSPPGSLPSARPLSLDGADSAPPPPAPSAPPPHHSQGFSVDNIMTSLRGSPQSAAAELSSGLLASAAASSRAGIAPPLALGAYSPGQSSLYSSPCSQTSSAGSSGGGGGGAGAAGGAGGAGTYHCNLQAMSLYAAGERGGHLQGAPGGAGGSAVDDPLPDYSLPPVTSSSSSSLSHGGGGGGGGGGQEAGHHPAAHQGRLTSWYLNQAGGDLGHLASAAAAAAAAGYPGQQQNFHSVREMFESQRIGLNNSPVNGNSSCQMAFPSSQSLYRTSGAFVYDCSKF
Protein: Lipolysis-stimulated lipoprotein receptor precursor (Zgc:114089) (Q4V8Y3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Endomembrane system {ECO:0000256|ARBA:ARBA00046288}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00046288}.
Interaction partners:
Sequence:
MSLGVIFTLLLFPGVTTGINVICTYPRYVVIMFQPVTLRCDFTTTSTTPPLITWKYKSYCRDPIQAALNPSSADNAIAQSNPNYNPNIECADSARTVRIVASKQTAVTLGKEYQGRQISITNNADLSIVQTAWGDSGVYVCSAASAQDLSGNGECYTELIVLDWLLVVLVVLGFLLLLLLIGICWCQCCPHTCCCYVRCPCCPERCCCPRALYEAGKMVKSGIPSQYAATAYAQSMYGQPAYGVGAAMPGIPMMPMQMGVGGPPSNGYGRDYDGASSIGQGSQVPLLQEHDAGGNRSGYRVQADQDGNPTRVLYYMEREVANLDPSRPGIAPVDGMSEVSSLHDGPESRNRGRARPPQLTTVYDDVDENMSTISSVSQHMRRDEPRRGADSRGRARSMENLDDISRGYRDRDDYPPARRDGGPRGGRRGSDDEWSSSGRGYDPVDDRRRRDYSPDNRPRRGDSFRGAGFQGRRTRSRDDLMDLVRDPGRGGRDEYDDSFLREAMEKKKLGEQQRGRSRERLDSESDRSDRYRGHHSGPPPLPLVPASGNPDRRGNHSNFPPPPPPYTEDTDSLPSSKKSNLKKNGAVSRESLVV
Protein: Uncharacterized protein, isoform D (M9NF18)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDVPDDNFGPSKPCDKQPLAGNSSSATNSSSHTGGNGNVDSAFESSTAAGPSSGANQSSTGGAIDEQGSIGEQSAGVGQNIIEGDLLVLNANSTNVDLSTHRDGSSFKDSNTEQGKKSTMIKTSKTLNDKSQFERRRRRGRQRERHREPSTHRDDLEPCDLGLMGWTGEFPKLTPISNIESNSDKEPLSTAKPGVLPWSGLKVFPRVEPQEETAAGTTKPAHITNKSEEQQQQPSLTTPIMTSPLDASQGELDAAIKSPLNAKKSPNATGIATTSKSSTTPTNMQPSDLYNQVEDKKEDTTKKQAEADHTLHKSLKDARIVKRSMSTHSPPEHSRRSVRFSSHTPLTDETNIMKETSTETSLKVIFERLKQTGVERDLFIPSSENPRPRSNGSPVPKVAEMEHVAVVKCKTVAKQGAVVKGKAGLANPSNVMPQTPALTVTGKRVSKPKVPKGASPPSEGWTSTRAVKGNSRADYTNSSSCGSPIGNTNIRRRRAHAKAAPDKSKPCVRCAASVHPSGPKLCKCIYEKGYANKKWMKKTGGNEDHYDDDDDSDFSMIEVTLENEISVQQAEKKQLENVNKQTVIKEQEVVVIGGRKAIAIIADPIGCNLKVIPNRQNLAGLKKISKDKCSSSLVQSLGDCHIGCQIVMAVMKIMTMKDRVNMAQVCKTWAMISQDKSVWRTVMLRDTHISNWPRFIRELANNCTRELDMLGVILPNPPDILATLDISVLKALRVLRTCPVDDQFLFKVFRELPQLLELRAICYSPTFNFLNLARQWSKIRVLQILMTDHRSKVESLDSLGDLVHLTELNIRGVNYIGSQDFRFLKKLVNLKVLVLSSCQGMDTEEFGQQVLPFLTSLRRLRLENKHMINTTFPLYHIMCGVAAACSVQQLELVNVEVDDLLTSLIGMCTTVTHLLLVPKCLQNSANVIYSVMRAVRENASQLRVFRLGLVTQLLSATGELYRGSKKDVIPVERPVPGIPLDDDLNYCAPDDRCIETDHTECVTFLPAKRLLMILRDVAPTTFVTFVKVNMFNSTMVTFLKRPQLKNK
Protein: AKIN gamma (SNF1-related protein kinase regulatory subunit gamma-1-like) (B4FX20)
Organism: Zea mays (Maize)
Interaction partners:
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- GMP synthase
- non-specific serine/threonine protein kinase
Sequence:
MDQPEENPEFPSCDAYFEAIQSKKKLPLTLQESLTAAFAQIPVSSFPEVPAGRVIEIPGDTSVIDAVRTLSEQNIRAAPVLNPEPGAPTDWQGRYLGVIDYSAIILWVLENAELAAVALSAASATAAGVGMGAVGAVGVAALGTTGPAAVAGLTAAAIGASVAGGLTAEKGVAKDGLTAADHLGEDFYKVLLQQEPFRSTTVRSIVESYRWSPFVPITLDTSMLTVLLLLSKYRLRNVPVIEPEKPIIRNFITQTGVVKGLQQCKGRDWFDYISALPLSDLGLPFMSIDEVITVNSDDLILEAFKCMKDNKIGGVPVVEGPKRKLVGSVSIRDIRFLLLRPNLFSNFRQLTVIEFMKTLGSTLPDSESNCLVKPPPTCTPDASLGSVIDSIASRITHRIYVVDDDLEVVGVVTLRDVISCFIHEPPGYCDNYLASAMEKLEGKGVRSVEKI
Protein: Cytoplasmic dynein 2 light intermediate chain 1 (Dynein 1b light intermediate chain) (Q7XA07)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Functions as a motor for intraflagellar retrograde transport. Functions in flagellar biogenesis.
Subcellular location: Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, cilium, flagellum membrane; Peripheral membrane protein. Cytoplasm.
Interaction partners:
Sequence:
MAAPAMLPGQAVKTPGSIWAKAIEHANEERKKPGADGRGDAFCYFVGSRAAGKSTLLNRFLYPTRAEVPKPSEGIEYTYARKPAAFDHEKKDLAHIWEVGGSQEFAEEIVNSDQLFLTAKQVTTAVVVIVVDLSDPAGVLPTLLYWVEQVKKKLGSTYEKFEKKGLQLPEQLRQRAKSKLYSANEDKDTVYHSGISLVIAATKYDAFKNQDPEVKKVMSRVLRYIAHAHGAFLCYLSGLHGASEGSGAEDAALLDNFTRLMNHLIFTGLEKKPVLKMQPQIDHTGPIMVPAGFDTFKSVGRPRSQGEGTVAGGLAEWRELFEKMFPGVREKEAKMSAKGAKFVIPEQYKEEEVDAVRQRKVTDLENFRKEQAAAVEAAKKKALMAKAQQAEAAAKKKAGAPAAGAKAPAKASPNGTPPRRPSNAGNQ
Protein: RE66324p (TNF-receptor-associated factor-like, isoform A) (Q8IR14)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH01161p
- FI05319p
- LD20892p
- LD40663p
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- ubiquitinyl hydrolase 1
- Caspase-8
Sequence:
MSLTKSSSRKDLTEQNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFTEHLIHCGQVLEECPNGCQAFIPRIRMRSHLKECPRNQHNLSNQQRMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNEEIRQRLHLITDVGNIRKQNQVVEDWTRETEKAMDDLRRQMEEETNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKLEELIFENERLNREKFFQIEEFLQQINEDIKTKLGNSDYVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAMQQRIASVQNIRGHLIWRIKDYSKKLEESKQYDTILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLNVLSGEYDPLLAWPCRLQAEIIIRDQCTNVADAEDYVKTIFVRKKSDDFIQSNQYFHIPHKVITSRNYLRNDSMFIEVRVLK
Protein: Cation/H(+) antiporter 6A (Protein CATION/H+ EXCHANGER 6a) (AtCHX6a) (Q8GX92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May operate as a cation/H(+) antiporter.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MATEEIDMSYWDVSWGEFNEDKNSSIFCESHPHIVNSHGIWEVMTFKRGMNFWEYPLPNLEILIFSTFFIWRLLDISFNKIGLRVPRFTYMMIAGIILGQTCHFSNKSWIHDIFFPDDNRPKVAETLGAFGFVLYWFLKGVTMDAELPFRTEKRSSVIGFITVIIPLICGSLTFRYRERRGDSSILRMEYRLIIFLQSISAFTSIDTLLKDLQIKHSEFGRIALSGAMVTDMLAFGVTFFNAIYYEKLYGFMQTVGFCLFVVVMICVVRPAMYWVIKQTPEGRPVKDFYLYSIFGIAFACFTFFNKVIHLFGPAGSFVFGLTVPNGYPLGTTLIQKFESFNLGSILPLFGSLTMMQVDLLRLFKESGDLIRMEGQIYEVISFILLVNTTKFVVTTITAYAFKMPLRDSFALALVLSNKGIFELAYYTYAVELKLIRPEVFTILAAYTLLNSIFIPMLLELVHDPTKRFRCYRKRNLGILKDGAALQCLMCVYRPDHITSMTDLLETFSPSQDSPMACNILHLVELVGQANPMFISHQLQKPEPGSTSLSDNVIISFRGFQRQFFEYTSLDIFTSVSVSQHMHEDICWLALSRSLSLIVLPFHRTWSVDRSTVISNDDNLRMLNVNVLRRAPCSVGIFVYRKPIVESHMAKSHSKICLIFNGGKDDREALAITNRMRLTEKRTRLTIIRFIPKSSEMDNDEWEQQQSINLKESVTSIVGSNIKENDAKVTYIDKAVSDGSETSRILRAMANDYDLFIVGSGSGIGTEATSGISEWTEFNELGPIGDLLASHEYPSSASVLVVQKQVYIHHTKSQRRKSF
Protein: Snake venom metalloproteinase crotalin (SVMP) (EC 3.4.24.-) (P0DJ42)
Organism: Crotalus atrox (Western diamondback rattlesnake)
Function: Snake venom zinc metalloproteinase that inhibits ristocin-induced platelet aggregation by abolishing the binding of von Willebrand factor (vWF) to platelet glycoprotein Ib alpha (GPIBA) through the cleavage of both GP1BA and vWF. Also has fibrinogenolytic activities by degrading the alpha- (FGA) and beta-chain (FGB) of fibrinogen. In vivo, induces a slight hemorrhage when applied to chick chorioallantoic membrane and has potent antithrombic effect.
Subcellular location: Secreted.
Interaction partners:
Sequence:
LLRRKSHDHAQNHDGDKCLRGASLGYYQSFLNQYKPQCILNKP
Protein: IAA-amino acid hydrolase ILR1-like 1 (EC 3.5.1.-) (P54969)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolyzes certain amino acid conjugates of the plant growth regulator indole-3-acetic acid (IAA), including IAA-Ala, IAA-Asn and IAA-Tyr.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Protein LONG AFTER FAR-RED 3
Sequence:
MALNNFLTFQLLLLLLRVSSESPWIVAGDVSRIPINFLELAKSPEVFDSMVRIRRKIHENPELGYEEFETSKFIRSELDLIGVKYRFPVAITGIIGYIGTGEPPFVALRADMDALPIQEAVEWEHKSKNPGKMHACGHDGHVAMLLGAAKILQQHRQHLQGTVVLIFQPAEEGLSGAKMMREEGALKNVEAIFGIHLSPRTPFGKAASLAGSFMAGAGAFEAVITGKGGHAAIPQHTIDPVVAASSIVLSLQHLVSRETDPSDSKVVTVTKVNGGNAFNVIPDSITIGGTLRAFTGFTQLQERIKEIITKQAAVHRCNASVNLAPNGNQPMPPTVNNMDLYKKFKKVVRDLLGQEAFVEAVPEMGSEDFSYFAETIPGHFSLLGMQDETQGYASSHSPHYRINEDVLPYGAAIHATMAVQYLKDKASKGSVSGFHDEL
Protein: Probable diguanylate cyclase DgcI (DGC) (EC 2.7.7.65) (Putative lipoprotein DgcI) (P75801)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules.
Subcellular location: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
Interaction partners:
- Probable cyclic di-GMP phosphodiesterase PdeI
- Probable diguanylate cyclase CdgI
- Probable cyclic di-GMP phosphodiesterase PdeK
- Probable cyclic di-GMP phosphodiesterase PdeG
- Cyclic di-GMP phosphodiesterase PdeH
- Probable cyclic di-GMP phosphodiesterase PdeN
- Blue light- and temperature-regulated antirepressor BluF
- Cyclic di-GMP phosphodiesterase PdeL
- Diguanylate cyclase DgcP
- Cyclic di-GMP phosphodiesterase PdeF
Sequence:
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVAIDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQVVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSLFKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPVDKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERLKMLADERLYKSKKNGRAQISWQ
Protein: Proteasome subunit alpha type-2 (20S proteasome subunit alpha-2) (Q9U793)
Organism: Trypanosoma brucei brucei
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MSESSYGLTTFSPSGRLVQIEYATTAASKGTTALGVKATDGVVIAAEKKTTSPLADSLTLHKVFALDDHVGCTYSGIGPDCRVLVDAARRACQRYRLTYHEPMPISQLVRQISFLFQEFTQSGGVRPFGCSLLVAGADSRGNHLYQLDPSGTFWTWKATSIGKGSPDARTFLEKRYTNEMEIEDAVHTALLTLKEGFDGRMTAENTQVGRVVEGRFELLTVEQLKDYLDQI
Protein: Succinate dehydrogenase subunit 3-2, mitochondrial (P0DKI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Succinate dehydrogenase subunit 5
- Succinate dehydrogenase iron-sulfur subunit 1, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 2, mitochondrial
- Succinate dehydrogenase flavoprotein subunit 1, mitochondrial
- Succinate dehydrogenase subunit 4
- Succinate dehydrogenase subunit 7B
- Succinate dehydrogenase iron-sulfur subunit 3, mitochondrial
- Succinate dehydrogenase subunit 8
- Succinate dehydrogenase subunit 7A
- Succinate dehydrogenase subunit 6
Sequence:
MAATALFRSIRRRDVVSAPLSVYKSLAGNAQPSWGSSYIGQNYASFSRAFGSKPVVNDILGTGLGTNNAIREEREKSKSTEAAIVGAQLTRSFRALDVGTSKRLFSTISGDIKTTQEEPKIKSFRPLSPHLSVYQPQMNSMLSIFNRISGVYLTGVTFAGYLLYLKMGMICLTYPSFYQVLYHTQQQLPVITSVTALAAIYHTIKSTHSLLTH
Protein: Ribosomal protein S3A (D6RB09)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLME
Protein: Cytochrome c-1 (Cytochrome c-distal) (P04657)
Organism: Drosophila melanogaster (Fruit fly)
Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Interaction partners:
- Apoptosome protein Dark
- Cytochrome b
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 4
- AT03047p
- BG1
- Cytochrome c oxidase subunit 4
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 2
- Cytochrome b-c1 complex subunit 9
Sequence:
MGSGDAENGKKIFVQKCAQCHTYEVGGKHKVGPNLGGVVGRKCGTAAGYKYTDANIKKGVTWTEGNLDEYLKDPKKYIPGTKMVFAGLKKAEERADLIAFLKSNK
Protein: Transmembrane protein 119 (Osteoblast induction factor) (OBIF) (Q4V9L6)
Organism: Homo sapiens (Human)
Function: Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20025746, ECO:0000269|PubMed:26250788}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8R138}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R138}. Secreted {ECO:0000269|PubMed:37453717}.
Interaction partners:
- P2Y purinoceptor 12
- Triggering receptor expressed on myeloid cells 2
- CX3C chemokine receptor 1
- Allograft inflammatory factor 1
- Olfactomedin-like protein 3
- Sal-like protein 1
- Macrophage colony-stimulating factor 1 receptor
- Probable G-protein coupled receptor 34
- Cystatin-F
- Complement C1q subcomponent subunit A
Sequence:
MVSAAAPSLLILLLLLLGSVPATDARSVPLKATFLEDVAGSGEAEGSSASSPSLPPPWTPALSPTSMGPQPITLGGPSPPTNFLDGIVDFFRQYVMLIAVVGSLAFLLMFIVCAAVITRQKQKASAYYPSSFPKKKYVDQSDRAGGPRAFSEVPDRAPDSRPEEALDSSRQLQADILAATQNLKSPTRAALGGGDGARMVEGRGAEEEEKGSQEGDQEVQGHGVPVETPEAQEEPCSGVLEGAVVAGEGQGELEGSLLLAQEAQGPVGPPESPCACSSVHPSV
Protein: Histamine receptor H2a (A0A2R8Q9U8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Histidine decarboxylase.
- Guanine nucleotide-binding protein G
- Uncharacterized protein.
Sequence:
MTSQIALAVTLSVLILLTVSGNILVCLAVYATRRLRNVTNCFIVSLAVTDFLLGALVLPFSTLYQVTGDWPLGAHFCNIYISLDVMLCTASILNLFAISLDRYFAVTAPLRYPMLVLPWRVGAILATIWLVSVGVSFVPIHLGWNTRDLSVQNIREGDHARDCRFELNPTYAIVDAFSTFYLPLLAMCWSYHRVFRIARMRAKRIISTRRGSTSSQGVTILTLREHKATVTLAVVLGAFVVCWFPYFTFFTIMGIRNEENPPQTAQSVVLWLGYANSALNPVLYATLNRDFRSAYAKLLCGGRRCKTETTIPIAATAAGTMTGHAHSSKGAGFLPRTCVLLKDSENRMLDDNSATNGATVTVVANGSKR
Protein: DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) (DNA-directed RNA polymerase II subunit K) (RNA polymerase II 7.0 kDa subunit) (RPB7.0) (RPB10alpha) (P53803)
Organism: Homo sapiens (Human)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
Subcellular location: Nucleus {ECO:0000269|PubMed:33335104}. Nucleus, nucleolus {ECO:0000305|PubMed:34887565, ECO:0000305|PubMed:36271492}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB11-a
- DNA-directed RNA polymerase I subunit RPA1
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
Sequence:
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR
Protein: Gene 66 protein (Gp66) (O64258)
Organism: Mycobacterium phage D29 (Mycobacteriophage D29)
Interaction partners:
Sequence:
MSNVWFTSDLHIGHAKVAEDRDWAGPDHDLHLAELWDEQVGKEDVVWILGDISSGGTRAQLDALGWLLNRPGRKRLILGNHDRPHPMYRDAPRLSRLYWNVLDYMSTAARLRVPLDGGGHTNVLLSHFPYVGDHTAEQRFTQWRLRDEGLILLHGHTHSRIIRSTMTNPRQIHVGLDAWHDLVPMDEVREMVNDIEEGL
Protein: Major vault protein (Q57Z03)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14764}. Nucleus {ECO:0000250|UniProtKB:Q14764}.
Interaction partners:
Sequence:
MSDIIRIKRHFYVHLLNNNTNVTKCMLGPQVYTRKEHERCLFEPRQCVVVPPGHYCVVQNPCVRGEDNIPKVGESEEVQLRMGEKEIRFEQPPFPLLPGEELLTVDGEWLFKLKVIPSNKGYHVRCTRDFVDSTRVSVRAGEQWIVEGPQTFIPRVEVEELGEVEALTVESNTAIKLRARLNFTDRQGVARVAGEEWLHRTSGAYLPAYEEEFVSYVRGAVLTEKEAIHLRALRNFTDVYGKARKAGEQWMITHKMSSTHIPDVNEVITATVNAIILSKNQYCIVKDPVGDEGINQFGKREVRKGECSFFLRPGESLVGEVQSMNAIGKNEALLLQALEKFEDCGGTVRMPGEKWLLRGATEYIPRVDVCVLERRGVIALDKNEGIYVMNTTTGEVRTVIGEPYMLKEHEVLWEKDLSPDVEELLACPTGCCRCSERDPNFTSSRVKHRIIRFNVQHNAAVQIYDYKQKKPRVVLGPNLVMLSPDEEFTVLSLSGGKPKALNSLLALQLFLGPRFSSDTIVVETSDHARLQLSLSYNWHFDVNRENPDAKIFSVPDFVGDCCKTIASRVRGAVAAEDFDSFHRNSAKIIREAVFGRDGNGHVRNSLRFSANNLVVTNIDIQSVEPTDAKTRDSLQKSVQLAIEITTKSQEAAARHGKERKDQEARGRLERQKLVDKIEVERTKTQWLELQAQSEVVQASGQAVAEAKAKAESLLIEADTELKQAEMRAKALRITAASDLAKQKQQQDLELEFAKRQNELEIVKARELAQTEVERIQRMVSAIGRQTLVSIAQAGPEMQAKLLGGLGLKGYLITDGKTPVNLFNTAQGMLGGQTTETKS
Protein: General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) (O60763)
Organism: Homo sapiens (Human)
Function: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}. Golgi apparatus membrane {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}; Peripheral membrane protein {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}. Note=Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes. {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}.
Interaction partners:
- Syntaxin-5
- Golgin subfamily A member 2
- Golgi SNAP receptor complex member 2
- Golgin subfamily B member 1
- Golgi SNAP receptor complex member 1
- Golgi reassembly-stacking protein 1
- Ras-related protein Rab-1A
- BET1-like protein
- BET1 homolog
- Sec1 family domain-containing protein 1
Sequence:
MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI
Protein: Cyclin-H (O17144)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
FTYPVSSQKRSWTFANEGQLMEFRVEQNSKYIESHEEEAQGRDLNEHFLTSAEERLLLKQYEIYLFDFCRRFEPTMPKCVVGTAFHYFKRFYLNNSPMDYHPKEILATCVFVACKVEEFNVSINQFVNNIKGDRNKATDIVLSNELLLIGQLNYYLTIHNPFRPIEGFLIDIKTRSNMQNPDRLRPHIDSFIDSTYYSDACLLHTPSQIALAAVLHAASREQENLDSYVTDLLFVSAREKLPGLIDAVRKIRIMVKQYQQPDREKVKAIEKKLDKCRNQANNPDSELYKERLRRLYTDEDDMPAEDASFHIADVSSDTSAMNISQ
Protein: Aliphatic amidase (EC 3.5.1.4) (Acylamide amidohydrolase) (O25067)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia. Hydrolyzes propionamide, acetamide and acrylamide, but has no activity with formamide or urea. The natural substrates of AmiE in its gastric environment are not known. Probably functions to ensure nitrogen supply to the bacteria.
Interaction partners:
Sequence:
MRHGDISSSPDTVGVAVVNYKMPRLHTKNEVLENCRNIAKVIGGVKQGLPGLDLIIFPEYSTHGIMYDRQEMFDTAASVPGEETAIFAEACKKNKVWGVFSLTGEKHEQAKKNPYNTLILVNDKGEIVQKYRKILPWCPIECWYPGDKTYVVDGPKGLKVSLIICDDGNYPEIWRDCAMRGAELIVRCQGYMYPAKEQQIAIVKAMAWANQCYVAVANATGFDGVYSYFGHSSIIGFDGHTLGECGEEENGLQYAQLSVQQIRDARKYDQSQNQLFKLLHRGYSGVFASGDGDKGVAECPFEFYKTWVNDPKKAQENVEKITRPSVGVAACPVGDLPTK