wanglab/gogpt-training-data huggingface dataset:
Protein: Small muscular protein (Stretch-responsive skeletal muscle protein) (Q9UHP9)
Organism: Homo sapiens (Human)
Function: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.
Interaction partners:
- Integrin beta-1-binding protein 2
- [Pyruvate dehydrogenase
- Cysteine and glycine-rich protein 3
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- Myozenin-2
- Ribose-phosphate pyrophosphokinase 1
- Alpha-actinin-2
- Ribose-phosphate pyrophosphokinase 3
Sequence:
MNMSKQPVSNVRAIQANINIPMGAFRPGAGQPPRRKECTPEVEEGVPPTSDEEKKPIPGAKKLPGPAVNLSEIQNIKSELKYVPKAEQ
Protein: DPP6 N-terminal domain-like protein (F8K7.10 protein) (Q9XI10)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Heavy metal-associated isoprenylated plant protein 32
- RGG repeats nuclear RNA binding protein B
- Valine--tRNA ligase, mitochondrial 1
- Small ribosomal subunit protein uS3x
Sequence:
MNISQIIFFASLLLRLHLSTAEHQNSNAGDGDTIIFTTLGRSHYEFDIFALSTTQPPSVSGELRITDGESVNFNGYFPSPSPALLSLLPDETLIQMEDSSPLHLIYVTERNGTSSLYYDLVYGGNSDFKTKRRSVLEAPSRVQVPLLSRFDHLSGMTVNSFKDKPSLSGEFIVYVSTHESSGEPRASWTAVYSTELKTGLTRRLTPSGVADFSPAVSPSGNLTAVASYGERGWTGEVEELRTDIYVFLTRDGSHRVKVVEHGGWPCWVDESTLYFHRRSEEDGWISVYRAILPENGPLTTESVTIQRVTPPGVHAFTPATSPNNHEFVAVATRRPGSDYRHVELFDLKRNEFIELTRLVAPKSHHLNPFLSPDSSRVGYHSCRGDANGRRSPLLFLENIQTTTRDLSLFRIDGSFPSFSPGGDRIAYVKMPGVFVVKPDGSGQREVYKGMAFSTAWDPVRPGIVYSSSGPTFATERTEVDVISIDVDAADKSSSVRRLTTNGKNNAFPWPSPDGKRIVFRSGRTGHKNLYIMDAEKGESGGLWRLTEGAWTDTMCNWSPDGEWIAFASDRESPGSGSFELFLIHPNGTGLRKLIQSGTGGRTNHPIFSPDSKSLVFTSDYAGISAEPISNPHHYQPYGDIFTVKLDGSNVRRLTHNSYEDGTPAWAPRFIHPNNVELQRRNDSRCSFEDCHWLNKYPTLKGRKISC
Protein: Cytochrome b-c1 complex subunit 7 (F7FFF0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004443}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443}; Matrix side {ECO:0000256|ARBA:ARBA00004443}.
Interaction partners:
Sequence:
MAGQPAVAASSKWLDGFRKWYYNAAGFNKLGLMRDDTMHETEDVKEAIRRLPENLYNDRMFRIKRALDLSMRHQILPKDQWTKYEEDKFYLELYLKEVIRERKEREEWAKK
Protein: ETS homologous factor (E9PQR6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTVDLLDSKTFCRAQISM
Protein: Actinin alpha 2 (A0A8I6ARF4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERTEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSILAIQNEVEKVIQSYSIRISSSNPYSTVTMDELRNKWDKVKQLVPVRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLVRCKLKFYKGLGPHQASIVGNVDVILF
Protein: Ribosomal lysine N-methyltransferase 2 (EC 2.1.1.-) (Q03942)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates 60S ribosomal protein L12 (RPL12A and RPL12B) at 'Lys-4' and 'Lys-11'.
Interaction partners:
- Ribosomal lysine N-methyltransferase 1
- Ribosomal lysine N-methyltransferase 3
- Ribosomal lysine N-methyltransferase 4
- Protein arginine N-methyltransferase 2
- Ribosomal lysine N-methyltransferase 5
- Histidine protein methyltransferase 1
- Alpha N-terminal protein methyltransferase 1
- Protein-lysine N-methyltransferase EFM2
Sequence:
MEGKVDVLLTWLKKSDKFYIAPNISICESPETGRGIVLSHGSIRKNDIIVSVPSSKQLNFHTILYHISKFNKELNIPGITIDRKPINYEDNIIEAENKAWADPRYGLYSELSKEFLLSLSSFQLVSFYILVENFLLPKWTHNEIYSDWKPFFDVWPSMEELRSIPAIWNCDPNSRYHSLIEYLPAASRKHMARISGLVREDWETISEVVLKWNEIYGSLSCTKNSDKFTSDELFSLFVHVYFIINSRCLYAKIPLKIEDSPSNFTLVPYVDFMNHICESDLHCYPQLSPQLRSEGENIIGIGQFTIRCGDHLYDNINEELFLNYGAHSNDFLLNEYGFVVDGNKWNYLDISDEIIELIDDDKKEVKTFLLEHDYWGDYTINETDISYRIFVALNYYVTRDERRVRKFIEGYISEDYFKPKISSVLKELLVSLTAKYTKTLSELTEKVSNLENNLCLQNLITIYKGYIKILTQHLQDLQS
Protein: Double-stranded RNA-binding protein Staufen homolog 1 (O95793)
Organism: Homo sapiens (Human)
Function: Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19029303}. Rough endoplasmic reticulum {ECO:0000269|PubMed:19029303}. Note=Localizes exclusively with the rough endoplasmic reticulum (RER).
Interaction partners:
- Regulator of nonsense transcripts 1
- Fragile X messenger ribonucleoprotein 1
- Regulator of nonsense transcripts 3B
- Double-stranded RNA-binding protein Staufen homolog 2
- Regulator of nonsense transcripts 2
- Polyadenylate-binding protein 1
- Y-box-binding protein 1
- ELAV-like protein 1
- Nonsense-mediated mRNA decay factor SMG5
- Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Sequence:
MSQVQVQVQNPSAALSGSQILNKNQSLLSQPLMSIPSTTSSLPSENAGRPIQNSALPSASITSTSAAAESITPTVELNALCMKLGKKPMYKPVDPYSRMQSTYNYNMRGGAYPPRYFYPFPVPPLLYQVELSVGGQQFNGKGKTRQAAKHDAAAKALRILQNEPLPERLEVNGRESEEENLNKSEISQVFEIALKRNLPVNFEVARESGPPHMKNFVTKVSVGEFVGEGEGKSKKISKKNAAIAVLEELKKLPPLPAVERVKPRIKKKTKPIVKPQTSPEYGQGINPISRLAQIQQAKKEKEPEYTLLTERGLPRRREFVMQVKVGNHTAEGTGTNKKVAKRNAAENMLEILGFKVPQAQPTKPALKSEEKTPIKKPGDGRKVTFFEPGSGDENGTSNKEDEFRMPYLSHQQLPAGILPMVPEVAQAVGVSQGHHTKDFTRAAPNPAKATVTAMIARELLYGGTSPTAETILKNNISSGHVPHGPLTRPSEQLDYLSRVQGFQVEYKDFPKNNKNEFVSLINCSSQPPLISHGIGKDVESCHDMAALNILKLLSELDQQSTEMPRTGNGPMSVCGRC
Protein: Acyl-CoA binding protein, putative (Q382P9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MWSKAEHLGEPVTFLLEVTDGVPADPAEFLDDLLQRLREVSLKGCIYEAACRVYNPLLVYVSLMDDPDTEPVDLENQDEVGIDEWFPLHLAIVLLRQEVVEAIVTFHRTYGGVVLDSVSCGSAIGTPCEYHDVEEQSGRISSLPVAPSCGSDALGVTMAGGVEKSQGQLNLGDRDARCQIRREFAGAFVVFGANSERSPLRDGGNNDSCNTSNGENVGALGLSSECKGVKWPFRLSCVSEALRPLLLRLVWEGTRHRGDRHCGCRRGRARGGSKGSDNAELVSLPEGCFTERIARLSNAARRNDTQPLSSILVDSTVMYDVCNGNIATLFDVLEVFDGLLLPVFCGETPLSVGDNGRLTTAGTGEQPDDTRGGGCGCVEASEKRMRQCQLPLQPHFYLSCPVQDPQKLAFILLWVDFRRSTLLKLEQHGPDIVGGYSPALRHGDVPATVPTAASLHSVHLFLLLQLVSLECTVQKFLPLVEAIDETQTVGDMPVTFVAALVAGAVAASFPQNGPLLLMMCEKLRVLLASASGEQAALRRYVASPPASEAERFSVLWLMATPSTPLKKFSSRAEMLYFGLVESVLLGAEKLWATQQVSVDARARDEAERALADWLVMCCDIFDGLKDCEDGTPLGFSRDMVYRLMGGCSPCPTLHSILHRQRHEVFTTTDVGEKSTSDFNTTGNRAAVQNPETAFAAAQQAFARIVGMVSNDMKLNIYALYKQATVGDINISRPWLTDVVGRAKWDAWCRVKGMSKEVAEQQYVSLVSALQEHRKSSIG
Protein: V-type proton ATPase subunit C (Q0PGG3)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MASRYWVVSLPVQSSASTLWNNLQDQISKHSFDTPLYRFNIPNLRVGTLDSLLALSDDLLKSNTFIEGVSHKIRRQIEELERVSGLETNALTVDGVPVDSYLTRFVWDEAKYPIMSPLREIVDGIHTQVAKIEDDLKVRVAEYNNVRGQLNAINRKQSGSLAVRDLSNLVKPEDIITSEHLVTLLAVVPKYSQKDWLSSYETLTTYVVPRSSKKLYEDNEYALYTATLFGRVADNFRTSARERGFQVRDFEYSPEAQESRKQELEKLVQDQYMLRSSLLQWCYASYGEVFSSWMHFCAVRVFAESILRYGLPPSPSFLACVLSPSVKGEKKVRSILEGLCDSANSTYWKTEDEGGAMAGLGGDTDAHPYVSFTINIA
Protein: CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (CTPsH) (UTP--ammonia ligase 2) (P70303)
Organism: Mus musculus (Mouse)
Function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity).
Interaction partners:
- CTP synthase 1
- Bis
- Nucleoside diphosphate kinase 6
- Nucleoside diphosphate kinase homolog 7
- Nucleoside diphosphate kinase A
- Nucleoside diphosphate kinase B
- Adenylate kinase 9
- Nucleoside diphosphate kinase 3
- Nucleoside diphosphate kinase, mitochondrial
- Ectonucleoside triphosphate diphosphohydrolase 8
Sequence:
MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAIQEWVMNQAKVSVDGNKEDPQICVIELGGTIGDIEGMAFVEAFRQFQFKAKKENFYNIHVSLVPQPSATGEQKTKPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVPLLLEEQGVVKYFQERLGLPINDCSSNLLFKWKAMADRYERLQKICSIALVGKYTKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFGIRGTLGKLQAISWARTKKIPFLGICLGMQLAVIEFARNCLNLKDANSTEFEPNTPVPLVIDMPEHNPGDLGGTMRLGLRRTVFTTENSILKKLYGDVPYIEERHRHRYEVNPNLINQFENKDLCFVGEDVDGKRMEIVELTSHPYFIGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAHLQQMNKLPYSDGYSDASDDSFPEAKLAELDLN
Protein: Phosphoglucomutase 5 (Phosphoglucomutase-like protein 5) (B0R0B3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Glucose 1,6-bisphosphate synthase
- ornithine carbamoyltransferase
- Glucose-6-phosphate isomerase
- Glucose-6-phosphate isomerase
- Galactose-1-phosphate uridylyltransferase
- Phosphoacetylglucosamine mutase
- UTP--glucose-1-phosphate uridylyltransferase
- UTP--glucose-1-phosphate uridylyltransferase
- Phosphoglucomutase-2
- GDH/6PGL endoplasmic bifunctional protein)
Sequence:
METNPIPILTIQTTPFDDQRPGTNGLRKKTAVFESNNNYLQNYIQSVLSSIDLRDRQGCTMVVGSDGRYFSRAATEVIVQMAAANGIGRLVIGHNGILSTPAVSCIIRKIKAIGGIILTASHSPGGPGGDFGIKFNVANGGPSPDTVIERIHQVSRTLEEYAICPDLHIDLSRLGRQDFDLENKFKPFRVEIVDSVEIYFNLLRGIFDFSGIKSLLTGPNQLKIRIDAMNGVMGPYVRRILCDELGAPANSAVNCVPLEDFGGQHPNPNPAFAGPLVDSMKGGEFGFGAAFDADGDRYMIMGENGFFVSPSDSLAVMAANLSCIPYFSQRGIRGFARSMPTSTAIDRVAKAMKVALYETPTGWRFFGNLLDSGRCSFCGEESFGTGSDHIRDKDGLWSVLVWLSIMAVRKQGVEEIVRDHWAKLGRNYFCRFDYEGVDGKAAFYLMRDLEAVITDKAFTTQKFSVGNTVYSVEKADNFEYIDPVDGSVSRKQGLRIIFTDSSRIIFRLSGSGSGTGATVRIYAESYERDPERHNRETQVVLGPLIAIALKISNIHERTGRRGPNIIT
Protein: Nucleoporin 43 (F5H0E3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEEIYAKFVSQKISKTRWRPLPPGSLQTAETFATGSWDNETKLSVLQENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNAD
Protein: Zinc finger protein CONSTANS-LIKE 13 (O82256)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00357}.
Interaction partners:
- RNA-binding
- At1g69250
- Putative scarecrow-like protein 16
- Cysteine-rich receptor-like protein kinase 18
Sequence:
MEAEEGHQRDRLCDYCDSSVALVYCKADSAKLCLACDKQVHVANQLFAKHFRSLLCDSCNESPSSLFCETERSVLCQNCDWQHHTASSSLHSRRPFEGFTGCPSVPELLAIVGLDDLTLDSGLLWESPEIVSLNDLIVSGGSGTHNFRATDVPPLPKNRHATCGKYKDEMIRQLRGLSRSEPGCLKFETPDAEIDAGFQFLAPDLFSTCELESGLKWFDQQDHEDFPYCSLLKNLSESDEKPENVDRESSVMVPVSGCLNRCEEETVMVPVITSTRSMTHEINSLERNSALSRYKEKKKSRRYEKHIRYESRKVRAESRTRIRGRFAKAADP
Protein: Scm polycomb group protein like 2 (B1AVB5)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Polycomb group RING finger protein 2
- Chromobox protein homolog 8
- Chromobox protein homolog 2
- Polycomb complex protein BMI-1
- Polycomb group RING finger protein 1
- RING1 and YY1-binding protein
- Chromobox protein homolog 6
- E3 ubiquitin-protein ligase RING2
- Polycomb group RING finger protein 6
- Chromobox protein homolog 7
Sequence:
MGQTANEDHFDWDKYLKETGSISAPSEYFRQSKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNTSSWPMFLLRVLTGSELAPAVFFKEEPPRPLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKIVEKRPRRKRRTRLWRLRTALLGNEEEAPEAAEEPGTSVLTFGDENRTLKDCRGEAAEEPGTSAFTFGDENRTLKDCQGGWKKPKGRGFIKPGKDETRPGKHDQGAPAGKKPRGRGFTQPLEDEARPGRDVQVAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKPKGKRVTKSRKDQAQFLADEEAMPALFSALSVSSTERTPPSSSEQPKSSTSGKTKSTSRGAQTSRKSPRKTSVVQPVPKTSKKAGKSKSTGNTSSPKKGITIKIVLPKKKGGKSGKKEKSIPVISSTSSASLSTLMKSSSSNKTSAGPSKIVMSTVCVYINKHGDCGPFLDPQKVQQLPNHFGPGPVNVILQRTVQACVNCAFQAKDVFLFLKTDNRGGEMITAFFDGKVHTVQLPPVNSASFALRFLENFCQSLQCDNFLSSQPFRREAQVPTPDTGTDQSKPENGEPKEKRSLKRLSLHPHRSAPVSSKVPRKSGQASKGN
Protein: Gartenzwerg, isoform B (A1Z8W8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- ADP-ribosylation factor 1
- Coatomer subunit gamma
- ADP-ribosylation factor 6
- FI01544p
- ADP-ribosylation factor GTPase-activating protein 1
- Guanine nucleotide exchange factor MSS4 homolog
- ADP-ribosylation factor-like protein 1
- Coatomer subunit alpha
- Coatomer subunit beta
- ADP-ribosylation factor-like protein 11
Sequence:
MALPGNGIYVVRGEMATLMTAMRRGTRWNATAYVDDENDSLLKLFIDLKHELNRIEDLRQIEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLADIVERIADAVTHARFMGTDQSSDGVTFMRVIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAPRKSSAVEEPPQTPQSANLTVPGHLKAPILATTPASPAGNILDMQGKITQTPTTTASTGEDETTVPETPVIQVESTESEPLLDGETGEATSTLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCNPLDKQNSDSMMHTGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYSTHIISMDTLLSVIDSIERNCAASKNSSNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDKSTETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEKPREKQESGLFSSLYSFISSEGQREPTYEEQDFIKLGRKCIKECQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPYAEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQIIFNLLECVGAGAVPPNYDDAQLPLPPNGSAKSDGAISGEEDATAVPERGYTSDSEITKASAAPAVSSPSAENWILVNNKDSELTTASRPQSPPSLSAPPVNTLVYNCQLLDHAPFALFKCWDSLAFIVRSVAHITPYNFEACVRCIRIFVEACRDGGIRQRRKLESAAKQKSSKKRSERKPGMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYEQLSIQLLDLMYTLYTRTAQIFRWWAEEGCTVPQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVHDLQTLSGTEWCSCFHQVLFPLLNELLPESNAAGQLDAALLEESRIRTATIMSKVFLQHLTTLIELGNAFNELWLDILDYIERFMKVGSDTLSEQMQEILKNMLLVMHSVRVFHNQDGSLQQALWELTWRRIGEFLPNLKEELFHDEGKRAQTLTNPAPQAAVAAAPQQQLPAVTILPRQTQVSNELVVSAPTPPAATPLLGSPVESPRRSIILQPPMADVLQQPPSFVFAQPIIVPPQPPAVTDPIPPSTLLPDLVNEATAAAVQATTTSPTHSPQEAEQPASIVQQTNIVTTNNTYNSYAIEVPMAPETTAEQFGQQQQQLLYQQYYQQYQAQQQQLPAPASDPAINVPISHLLAGNAYPSLPKMPQASIVHSFAPVYESQAATSGAGTAAADIYQEYVQNPYNLTLQQHPQQQLHQQQQQQQQQATGMANAFPAVATPANYFNVNVDPSSIPPGSELLYGQQ
Protein: Centrosomal protein of 89 kDa (Cep89) (Coiled-coil domain-containing protein 123) (Q9CZX2)
Organism: Mus musculus (Mouse)
Function: Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. {ECO:0000250}.
Interaction partners:
- Sodium channel and clathrin linker 1
- Centrosomal protein of 83 kDa
- Centrosomal protein of 164 kDa
- Fas-binding factor 1
- Ninein
- Outer dense fiber protein 2
- Centromere protein F
- Trichoplein keratin filament-binding protein
- Centrosomal protein of 128 kDa
- ATR-interacting protein
Sequence:
MLLSFRRNRRSQFNHIIHGFLPAASIAPKPAVPRTPPPRSPNPSPERPRSALAAAILATTLTGQTVAIPQPRQRSRSESDASDIEKDSFIKPYATTSELRLRQSWQNEPRRTSLPSFEMLGYGEDEDAETQVSTSCRESESTWKDVGDGRDATYTVPHRDQVLPSQKLVRKDDAPQPDWLSDSSSSSSSSTPQHTQQKDVKHSVLNLEGEKVRLHEKPPPSPDVAGRIHQRYTEITKEKFAELKEETVHLYSANQALSCELSALRQAMKDLQLKLKLVEKDNRKLKETEKASCQEGVTPELLCLRKQSQDLVDENEGLKMIVHRLNVELSRYQTKFRPLSEEESSHIQGLPSKGPTPPWLVDIKYLSPLLLAYEDRMKEKDKLSTALEEEMKTFRLRVQEVVKENEALHQELTKRSPVTVEEWRQLQTQAELVLDENKLLIEQLEIQQAKARDTHQAHLQDVSKLTKQLVLLEAKTQGQEKQLVESTEQLESLQAKCTELKAQLDSKIAVDVHTSIVNELKSQLQKEEEKDSAEMEELMAKLTALQVQKKSLLLEKSSWATRNRALEAELERTRKANRRYQKRIDVLRKQVEKAMGKEMSAHQYLANLVGLAETVTKERDSLKYLAQCLESEKHGVLNKILKGNIRLGKLEERVKGYKKQAALKLGDIHHRLKEQQEDFAGKAAQYQKEVKHLHRMLQEKQEVLDEALQQKRNMEGELEMVLESTAKENRRMRSLLQATLERRSTQHVTAPPDTCLRRSSQGDLLIGHDFSYGDVQLLATTNRQSLGESMA
Protein: Intraflagellar transport protein 172 homolog (Q5RHH4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for the maintenance and formation of cilia.
Subcellular location: Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Intraflagellar transport 81 homolog.
- Intraflagellar transport 88 homolog.
- Intraflagellar transport 52 homolog
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport 80 homolog
- TRAF3-interacting protein 1
- Intraflagellar transport protein 70A
- Intraflagellar transport protein 46 homolog
- Clusterin-associated protein 1 homolog
- Intraflagellar transport protein 56
Sequence:
MQLKYMKTLLTPQDGAAKVTCMAWAPNNAKFAVCTIDRVVILYDEQGEKRDRFTTKPADPKYGKKTYVVKSMAFSPDSTKIAVAQTDNIIFVYKIGEEWGDKKVICNKFIQTSAVTSLVWPSEHAIIFGLAEGKVRQANTKTSKSSTIYGTDSYVVSLTSNVSGKGILSGHADGTVVRYFIDDEGSGESQGKLLTHACPPYALAWGTNSIIVAGCDKKIVAYGKEGNVIQTFDYSRDRAEKEFTVAASSPSGQSIVVGSFDRLRVFNWSPRKGTWDESSPKEIPNLYTITALSWKKDGSRLSVGTLCGGVEMFDCCLRRSIYKNKFEMTYVGLSQVIVRNLSTGTRVVLKSQYGYEIDEVKVMGKDQYLVAHTSDTLLLGDLVSNKLSEVAWQGSGGNEKFFFENETVCMIFNAGELALVEYGSNDILGSVRTEFMNPHLISVRLNERRQRGVEDNKKLAYLIDIKTIAIVDLVGGYNLGTISHDSKIDWLELNETGRKLLFRDKKLRLHLYDIESSVKSTMLSFCPYVQWVPGSDVVVAQNRGNLCVWYTIDSPERVTMFPLKGDIVDLERSNGKTEVIVNEGVNSISYTLDEGLIEFGTAIDDGDYYRATAFLETLEMSAETEAMWKTLSKLSLEAQQLHIAERCFAALGDVSKARFLNETNKIADAVAKEYDGDGTDHYQVKARLAMLDKNFKLAEMYYMEQNAVDEVMEMYQELHMWDECIAVAEGKGHPELDNLRRSYYSYLMETNQNEKAAEVKENEGDFTGAVNLYLKAGLPAKAAWLAMSKDELLSSQDIVSRITAALIKGEFYERAGDLFERTRNNQRALECYRKGNAFKKAVDLARVAFPAEVVKLEEVWGDYLVQQKQMDAAINHYIEAGRSIKAIEAAIAARQWKKALHILELQEDRTAAKYYLKIAQYYASVQEFEVAERLFVKGDHIKDAIDMYTQAGRWEQAHKLAVKCMTQEDVSVLYVSRAQELEKEGKYKEAERLFTTVDEPDLAITMYKKNKMYDDMIRLVAVHHKDLLQETHIHLAKELEAESRFQEAEYHYLEGQDWKAAVNMYRVNDMWEEAYRIAKTHGGANAHKQVAYLWAKSLGGEAAVKLLNKFGLLETAIDFAADNYTFDFAFELARLSMKQKIPDIHLKNAMFLEDQGKFNEAEIEFIKAGKPKEAVLMHVHNKDWSNAQRVAEAHDPESVADILVSQAKFCFDQKEFQKAEAFLLRAQRPELAIKYYKDAGMWTDAMRICKDYLPSKLSVLQKEYESEGNWGVEGMIEQAQEWEQTGEYSRAVDCYLKVKDSSNLDLLLKCWMKAAELAIKFLSHDKAVDVSQIVGPRLIQLRKYNEAAELYLNLDLIKNAIDAFIEGEEWNKAKRVAKELDPRLEEYVDKRYKEHLKNQGKVDSLVGVDVVAALDMYAERGQWEKCIDTASKQNFKVLHKYIALYATHLIKEGEVEKVLSLYIQHGVPAYSQNFNIYKRMFQELVNLRDRDCAEAFRMWSDLRDVLLLLCENLTKSSEANSPAHEEFEQMLLVAHYYATRSAAKGIDQLSSVAAKLSISLLRHTELIPADKAFYEAGLAAKAVGWENMAFIFLNRFLDLADGIDEGTLDALDHTDFQDTDIPFEVPVPSRLHVTVEKREEIREWVLTVSMDQRVEQVLPKDERGTYEASLVAASTGIRSLPCVITGYPVLRNKIEFKRPGMAANKDDWNKFLMATKTTHSPECQDVLKFITQWCGGLPSAGYSFH
Protein: Doublesex- and mab-3-related transcription factor 1 (Q9PTQ7)
Organism: Gallus gallus (Chicken)
Function: Transcription factor that plays a key role in male sex determination. Acts both as a transcription repressor and repressor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
- Aromatase
- TGF_BETA_2 domain-containing protein.
- Forkhead box protein L2
Sequence:
MPGDSPVVSKRAAPKPRRAAMPGDSPVVSKPPDGAGPGDKAGGLGKAAAQMAAAPAAGKKLPRLPKCARCRNHGYSSPLKGHKRFCMWRDCQCKKCSLIAERQRVMAAQVALRRQQAQEEELGISHPVPLPSAPEPVVKKSSSSSSCLLQDSSSPAHSTSTVAAAAASAPPEGRMLIQDIPSIPSRGHLESTSDLVVDSTYYSSFYQPSLYPYYNNLYNYSQYQMAVATESSSSETGGTFVGSAMKNSLRSLPATYMSSQSGKQWQMKGMENRHAMSSQYRMCSYYPPTSYLGQGVGSPTCVTQILASEDTPSYSESKARVFSPPSSQDSGLGCLSSSESTKGDLECEPHQEPGAFAVSPVLEGE
Protein: Type 2A phosphatase activator TIP41 (PP2A phosphatase activator TIP41) (TAP42-interacting protein 1) (Q12199)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Indirectly activates the PP2A phosphatase SIT4 via interaction with its suppressor TAP42. This interaction is enhanced under nitrogen limitation conditions. Also has a role in regulation of NPR1 in response to nitrogen limitation.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Type 2A phosphatase-associated protein 42
- Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
- Serine/threonine-protein phosphatase PP1-1
- SIT4-associating protein SAP155
- Serine/threonine-protein phosphatase 2A activator 1
- SIT4-associating protein SAP185
- Serine/threonine-protein phosphatase 4 catalytic subunit
- Leucine carboxyl methyltransferase 1
- Serine/threonine-protein phosphatase 2A activator 2
Sequence:
MSKRNTPPLRSSGINTIQINAAREMHAQTVRARRMPMPTSGITTPSVQPTAAPATPPRHICNNPNNPQCLHCGSVIIPSPRATLPLEDNPSISINDWTISSRKKPILNSQELDIWENEKLKGLTLPEMIFGNNYIRIENSKQHWSIEFNALDALKEVQLQDSGIRVAYSNDWINSKKRQNSTNGAQRFTNDVNDDSLNIIHKYDWTYTTRYKGTESSPESKFRLDNDQKLPLDKLAVHDKILFYDDMILFEDELADNGISILNVKIRVMNERLLLLSRFFLRVDDVLVRVYDTRIYVEFDENVVIRESKEFEGKYQDVLAKHRLSQSHDPKAALRDSNWVAQNTPMIKRQCEIIQF
Protein: Ubiquitin-conjugating enzyme E2-17 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 6) (RAD6 homolog) (dRad6) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) (P25153)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the putative E3 ligases poe, Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK.
Subcellular location: Nucleus.
Interaction partners:
- E3 ubiquitin-protein ligase Bre1
- E1 ubiquitin-activating enzyme
- E3 ubiquitin-protein ligase UBR1
- Ubiquitin-ribosomal protein eS31 fusion protein
- GEO06356p1
- GH17761p
- Polyubiquitin
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-like domain-containing protein
- Nedd8-activating enzyme E1 catalytic subunit
Sequence:
MSTPARRRLMRDFKRLQEDPPTGVSGAPTDNNIMIWNAVIFGPHDTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKVFHPNVYADGGICLDILQNRWSPTYDVSAILTSIQSLLSDPNPNSPANSTAAQLYKENRREYEKRVKACVEQSFID
Protein: Hepatic triacylglycerol lipase (HL) (Hepatic lipase) (EC 3.1.1.3) (Lipase member C) (Lysophospholipase) (EC 3.1.1.5) (Phospholipase A1) (EC 3.1.1.32) (P11150)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles. Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position.
Subcellular location: Secreted {ECO:0000269|PubMed:2828141}.
Interaction partners:
- Apolipoprotein B-100
- Gastric triacylglycerol lipase
- Lipase maturation factor 1
- Lipoprotein lipase
- 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
- Patatin-like phospholipase domain-containing protein 2
- Cholesteryl ester transfer protein
- Apolipoprotein E
- Apolipoprotein A-I
- Pancreatic triacylglycerol lipase
Sequence:
MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR