wanglab/gogpt-training-data huggingface dataset:
Protein: Protein lethal(2)essential for life (Protein Efl21) (P82147)
Organism: Drosophila melanogaster (Fruit fly)
Function: Vital role in embryonic development.
Interaction partners:
- IP07647p
- Muscle-specific protein 20
- Heat shock protein 68
- RE23625p
- Heat shock protein 83
- Heat shock 70 kDa protein cognate 4
Sequence:
MSVVPLMFRDWWDELDFPMRTSRLLDQHFGQGLKRDDLMSSVWNSRPTVLRSGYLRPWHTNSLQKQESGSTLNIDSEKFEVILDVQQFSPSEITVKVADKFVIVEGKHEEKQDEHGYVSRQFSRRYQLPSDVNPDTVTSSLSSDGLLTIKAPMKALPPPQTERLVQITQTGPSSKEDNAKKVETSTA
Protein: Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) (P07741)
Organism: Homo sapiens (Human)
Function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Subcellular location: Cytoplasm.
Interaction partners:
- Adenosine kinase
- Purine nucleoside phosphorylase
- GMP synthase
- Hypoxanthine-guanine phosphoribosyltransferase
- Adenylosuccinate lyase
- Inosine triphosphate pyrophosphatase
- S-methyl-5'-thioadenosine phosphorylase
- AMP deaminase 2
- Adenylate kinase 9
- AMP deaminase 3
Sequence:
MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE
Protein: Transcription factor elt-1 (H9G2S5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKKDGIQTRNRKLSAKGSRRMKKENGGTPTSMGMPTTSSSISSGIELDQSGVWGMKNTQPMLMTPTAYAFPASNFYFNSIEDQLEYKTCPPMMVDFGGQMKNLNLN
Protein: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC 3.2.1.183) (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (EC 2.7.1.60) (ManAc kinase)] (Q91WG8)
Organism: Mus musculus (Mouse)
Function: Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Required for normal sialylation in hematopoietic cells (By similarity). Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Plays an essential role in early development.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35826}.
Interaction partners:
- N-acetylneuraminate-9-phosphate synthase
- N-acetylneuraminate lyase
- UDP-N-acetylhexosamine pyrophosphorylase
- N-acylglucosamine 2-epimerase
- UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
- UDP-glucose 4-epimerase
- CMP-sialic acid transporter
- GDH/6PGL endoplasmic bifunctional protein
Sequence:
MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPAFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKCKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERISLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPQEGVVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAAMAERKFGQGKGQENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNVKAQSILRTAGTALGLGVVNILHTMNPSLVILSGVLASHYIHIVKDVIRQQALSSVQDVDVVVSDLVDPALLGAASMVLDYTTRRIH
Protein: Subtilisin-like protease 1 (SbtM1) (Subtilase 1) (EC 3.4.21.-) (A9QY40)
Organism: Lotus japonicus (Lotus corniculatus var. japonicus)
Function: Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e.g. Glomeromycota intraradices).
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:19220794}. Note=Accumulates in the intercellular spaces and the periarbuscular space (PAS) during arbuscular mycorrhizal (AM) symbiosis. {ECO:0000269|PubMed:19220794}.
Interaction partners:
Sequence:
MEQTKYRMELVLLLGLISMLSFIPASIAAEEGQEHDNLTTYIVHVKKLEIEGPLQSTEELHTWHHSFLPETSNKDRMVFSYRNVASGFAVRLTPEEANALQEKEEVMSIRPERTLSLHTTHTPSFLGLRQGQGLWNDSNLGKGVIIGVIDTGIYPFHLSFNDEGMPPPPAKWKGHCEFTGGSVCNNKLIGARNLVKSAIQEPPYEDFFHGTHTAAEAAGRFVEGASVFGNARGTAAGMAPDAHLAIYKVCSSKVKDECPESAILAAMDIAIEDGVDVLSLSLGLGSLPFFEDPIAIGAFAATQKGIFVSCSAANSGPHYSSLSNEAPWILTVGASTIDRKISASAKLGNGAEYEGETLFQPKDFSSQLLPLVYAAAEKNNSSALCAPGSLRNINVKGKVVVCDLGGGIPFIAKGQEVLDAGGSAMILANIENFGFTTLANAHVLPAVHVSYAASLAIKAYINSTYTPTATVLFQGTIIGDSLAPSVAAFSSRGPSQQSPGILKPDIIGPGVNILAAWAVSVDNKIPAFDIISGTSMSCPHLSGIAALLKSAHPDWSPAAIKSAIMTTANTLNLRGLPILDQRLQPADIFATGAGHVNPVRANDPGLVYDIQPEDYVPYLCGLGYSDREVTIIVQRSVRCFNVKSIAQAELNYPSFSILLGSDSQFYTRTLTNVGPANSTYTVKIDVPLAMGISVSPSQITFTQVNQKVAYFVDFIPQIKENRGNHTFAQGAITWVSDKHVVRTPISVIFK
Protein: Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative (Q4GZ10)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSRNGSLAGCYVDEFDEAATTKPETSSIYRYGRPVYEGTPTACFEGGLLFRIVEEGKNNRWSFYNDTPSNQMRVEVIFGANSAIKALGNTSLIKLPDGSYKGTVTVYPLETEVFVEGKCDTYESNIVAEELSTEYLQDVAVQNAKVIEKETQEVSKLGGENSSPDDTLAACIAKKTKFVDLIFPPGQESLQIGTPHKLKVIPWERPSMYLSDENALHARLFRNNIHPGNIDEGELGDSWFTGALACMAEFPDRVRDMFRHPRSIEEGKNEREIGAYRVTFNKDGWWTNVIIDDYLPCSGGHPMFARSYGDPMELWVSLAQKAYAKLHGGYGFLVVGDPLRALQDLTGFPCSSFNTAFENAKMNGGEELFVHLLQYGQTSYQTILTVPTRGALKLQGASVEAYEATGLLPGHVYTVLSVMPFPEYNLRLLLLRNSWANHSKHRWNGAWKRGSEKWKQYPGVAAACAGACDADGVLCVEWSEALALFAGCGVCFVQDTPYDYRIRGCFQKAIPSVCLEISVSVPIVLCLSLTQEGCHGTDKADYSPIMLSVAHGSGCNQIMTVEANSGFDADHPNPGFTFFETREANMFFHMIPEKSPYLIIPRTMTPYKELSYVLSIHSPVEIGTPESAVFVAFRTLAPECGVFANCRNFQVQGSTCQAEFQARGTEQFFPDIYLGNSIELS
Protein: hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29) (Q9VN98)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MITSTTTDYKNFFKHSAHPANAEQYFRELLDKRERRYEDLCRNIISDMNQYGLSVVDDFLGMETGLKILNEVRSMYNAGAFQDGQVVTNQTPDAPAVRGDKIRGDKIKWVGGNEPGCSNVWYLTNQIDSVVYRVNTMKDNGILGNYHIRERTRAMVACYPGSGTHYVMHVDNPQKDGRVITAIYYLNINWDARESGGILRIRPTPGTTVADIEPKFDRLIFFWSDIRNPHEVQPAHRTRYAITVWYFDAKEREEALIRAKLENSKTNNLAAQAQAQQAEPDSTTTPPAAPASSASSLPVSMSTGTGALNANVSSNSCATSSEICT
Protein: ATP-dependent DNA helicase PIF6 (EC 3.6.4.12) (DNA repair and recombination helicase PIF6) (Q38CE9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of genome stability.
Subcellular location: Nucleus {ECO:0000269|PubMed:19646907}.
Interaction partners:
- Helicase, putative
- TFIIH basal transcription factor complex helicase/translocase XPB subunit
Sequence:
MVVLRPKITLTSVRGRIQVTAEDGERVGPWGGTECFLSRQTGQGPCLVVRSSRHKRHQGTFFRLEGVRQVLSLYAMEGKLTVVVPHQKRLCSVFIETFADVDALQMMAATLQDRSRWKDIEKNVACRVQRITRTNVVDTKRITNMDGGTDTHLDYKQFEWGGGEDDSCAVGGVSCNPLEGARGERNGDGVESILQERPTGLPSAHSGGKLPKHMGGDELNPQLEGSTTPGRMQWTTDQIVATRLVCTGSNVFITGSAGTGKTEWLLHLVRNVLPRDDRTVVTASTGMSARLLGGCTIHSFAGIGRGEGGFNRVYNRVKSKPEVVRAWRQCQTLIIDEIGNISPDTFSMIDEIARSLRGAPEKPFGGIQVILLGDFLQLPPVDSPKARNEWTNGNDTDTDSNPIPGKLKWCFETATWESLKLALVGFRKSYRQMNDPDFALCLEDIRFGRYTRRVERILNECSTRQIKERHGIEPTLIVARRDEATEYNAERLKMLEDVHFHRYESEDYAAIPGMNLEKEVSLQQLLELRIGAQVVLLASLPDAPHLSNGDQGVVVSFAEQTRGPALPVVCFATSGGEEVLVPRVSMEVLGPEGRVIATRTQIPLQLSWAITVHRAQGMTLPLVSVRLNKCFFDCGQAYVALSRVRSREDLMLTAFDPSAIFADARAVAFYEKNFPAQRQSVEDTECELVPIKGKTRAKHPRSQGEKNSVDEGGNAPEEHPLRTDAAFTAYHDLDSQVSTDMPLVPQPPRKKRMLVEELPQVTSSAIPNFTQESNNGDANSQLQHPFSQNNLMVDDD
Protein: Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (C9JMB8)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Interaction partners:
Sequence:
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQQFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLKDFFTSGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKMFFFPSSDSTLHTRPPHGAAPSIDTSFTLSGL
Protein: Calpain 1, (mu/I) large subunit a (B8A6G0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Calpastatin
- BH3-interacting domain death agonist
- Calpain small subunit 1a
- Calpain small subunit 1b isoform X1
Sequence:
MFSYGGISAHISANRLKADGAGSFEQALHFQNQDYEALRQECLEGGYLFEDPCFPAEPPSLGFKELAPHSSKTRDVEWMRPTELCDDPQFIVGGATRTDICQGALGDCWLLAAIGSLTLNERLLHRVVPHGQSFQDDYAGIFHFQFWQFGEWVDVVIDDRLPVKDGELMFVHSAEGNEFWSALVEKAYAKLNGSYEALSGGSTTEGFEDFTGGVSEMYELRKAPRDLYRIISKALDRGSLLGCSIDITSAFDMESVTFKKLVKGHAYSVTALKQVEYRGRMERLIRIRNPWGQVEWTGAWSDNSPEWDEIDPSEKDDLHLQMEDGEFWMSFGEFLRQFSRLEICNLTPDALSDDDMSHWNTIKFHGAWRRGSTAGGCRNHPNTFWINPQYKITLLEEDDDPEDEEVACSFLVALMQKDRRRYRRHGQDMHTIGFAIYEVPEEYTGCQNVHLKKDFFLSNSSAARSETFINLREVSTRLRLPPGEYIIVPSTFEPSKEADFVLRVFTEKQSETEELDDEISADLEDEEEITEDDIDDSFKSLFAQLAGEDMEISVHELKTILNRVVSKHKDVKTDGFSMDSCRTMVNLLDKDGSARLGLVEFQILWNKIRKLLGIFREFDIDKSGTMSSYEMRLAVESAGFKLNNRLNQILVARYAENEAIDFDNFVCCLIKLEAMFRSFQQLDREETGTAEMNLSEWLFMTMCG
Protein: GH08448p (Q9VG03)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
METDKEKQSDELMNRIRNELTAILSQEAADDSDKEASQELLLSPNPLPIFGPIRKTRKAKSRSSKKNNSKASSSSAGSTKSSSSGTRSSEDRLTGGGAQEKPSDPVSTSSSYSLRSGYDAPPVEASARADFLESQAAKSIDEDVRKMQLELKQSYELFQGIGEKLESVSFTGLKDRIRDLHLNESNNELGKATTAELQMMFDQRFLQNRLDKLSTDATQGFRRHPGEFGDIPELSTFFQACTQLERGLDALRQQRRRNSELEKRLCWATEIAYDRMDEIRNAVGSDPEKNF
Protein: Histone H3.3 (P84245)
Organism: Rattus norvegicus (Rat)
Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H4
- Cbx5 protein
- Histone acetyltransferase type B catalytic subunit
- Histone deacetylase 1
- DNA
- DNA
- V
- Lysine-specific demethylase 6B demethylase 6B)
- DNA
- [histone H3]-lysine
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein: 7-carboxy-7-deazaguanine synthase (CDG synthase) (EC 4.3.99.3) (Queuosine biosynthesis protein QueE) (O31677)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
Interaction partners:
- 6-carboxy-5,6,7,8-tetrahydropterin synthase
- 7-cyano-7-deazaguanine synthase
- NADPH-dependent 7-cyano-7-deazaguanine reductase
- Queuine tRNA-ribosyltransferase
- GTP cyclohydrolase 1
- Epoxyqueuosine reductase
- S-adenosylmethionine:tRNA ribosyltransferase-isomerase
- Probable flavodoxin 1
Sequence:
MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSAFTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENNIRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSLKVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVAVDAELNLVRVLPQLHTLLWGNKRGV
Protein: Palmitoyl-protein thioesterase 2 (G8JLL2)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
Sequence:
MLGLCGQRLPAAWVLLLLPFLPLLLLAAPAPHRASYKPVIVVHGLFDSSYSFRHLLEYINETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMAKAPQGVHLICYSQGGLVCRALLSVMDDHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWH
Protein: Transcriptional regulator, TetR family protein (A0R6C9)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Interaction partners:
- Nitroreductase NfnB
- Decaprenylphosphoryl-2-keto-beta-D-erythro-pentose reductase
Sequence:
MTKPRGRGGRERIVAAAAALFEAQGITATTMEQIAAKAPVSKRTLYAHFPTKDDLVVEFLQYVYRSGLTVESALYDADVPARERILAMFTVPTRGDGPVRGCPFVAAATEFPDPDSPAHAYTRERKQAFTLRIAELLTELGADDPHGLAEQLAILTDGVASRSMVFNDARRGDVGRAAAEALLTAAGL
Protein: G-protein coupled receptor 171 (D4A4Q2)
Organism: Rattus norvegicus (Rat)
Function: G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception. Acts as a negative regulator T cell function (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:24043826}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55}.
Interaction partners:
- ProSAAS
- G-protein coupled receptor 83
Sequence:
MTNSSMFCPIYRDLEPFTYFFYLVYLIGIIGSCFATWAFIQKSTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLVHSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMVIPIKNIKEKSNVGCMEFKREFGKNWHLLTNFICVAIFLNFSAIILISNFLVIRQLYRNRDNANYPSVKSALLNILLVTASYIICFVPYHAVRIPYTLSQTEVISDCSTRIALFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKVTETFASPQKMKAREEKPRRENDVQSTGSAC
Protein: Olfactory receptor 2A25 (Olfactory receptor 2A27) (A4D2G3)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
MGGNQTSITEFLLLGFPIGPRIQMLLFGLFSLFYIFILLGNGTILGLISLDSRLHTPMYFFLSHLAVVDIACACSTVPQMLVNLLHPAKPISFAGCMTQMFLFLSFAHTECLLLVVMSYDRYVAICHPLRYSTIMTWKVCITLALTSWILGVLLALVHLVLLLPLSFCGPQKLNHFFCEIMAVLKLACADTHINEVMVLAGAVSVLVGAFFSTVISYVHILCAILKIQSGEGCQKAFSICSSHLCVVGLFYGTAIIMYVEPQYESPKEQKKYLLLFHSLFNPMLNPLIYSLRNKEVQGTLKRMLEKKRTS
Protein: E3 ubiquitin-protein ligase (EC 2.3.2.26) (F1LRN8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGPEPWETISEEVNMAGDSLSLALPPPPASPVSRTSPQELSEELSRRLQITPDSNGEQFSALIQREPSSRLRSCSVTDTVAEQAHLPPPSTPTRRARSSTVTGGEESTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLVEPQIRRPRSLSSPTVTLSAPLEGAKDSPIRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPVSILQRHEMVQKCVLILPKFMGSLCTCPSAPCPSAPCPSAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Protein: Glycine amidinotransferase, mitochondrial (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (Transamidinase) (P50442)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. Also capable of catalyzing the synthesis of a range of neuroactive guanidino compounds by utilizing alternative amidine donors and acceptors for the transamidination reaction.
Subcellular location: Mitochondrion inner membrane {ECO:0000250}.
Interaction partners:
- Guanidinoacetate N-methyltransferase
- Antizyme inhibitor 2
- Arginase-2, mitochondrial
- Arginase-1
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Serine hydroxymethyltransferase
- Nitric oxide synthase 3
- Alanine--glyoxylate aminotransferase
- Glycine N-methyltransferase
- Nitric oxide synthase 1
Sequence:
MLRVRCLRGGSRGAEAVHYIGSRLGGSLTGWVQRTFQSTQAATASSQNSCAAEDKATHPLPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTVEVKANTYEKYWPFYQKNGGLYFPKDHLKKAVAEVEEMCNILSMEGVTVKRPDPIDWSLKYKTPDFESTGLYSAMPRDILMVVGNEIIEAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYDQDYPIHSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPTPVIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVNIRNANSLGGGFHCWTCDVRRRGTLQSYFD
Protein: Methyl-CpG binding domain protein-like, isoform C (A0A0B4KGZ0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Chromodomain-helicase-DNA-binding protein Mi-2 homolog
- Histone deacetylase HDAC1
- Metastasis-associated protein MTA3
- Simjang, isoform E
- Chromodomain-helicase-DNA-binding protein 3
- Protein deacetylase HDAC6
- Chromatin assembly factor 1 p55 subunit
- CDK2-associated protein 1, isoform B
- MOG interacting and ectopic P-granules protein 1
- Paired amphipathic helix protein Sin3a
Sequence:
MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSSPTGKRAEGKPQDIAIPDFQPGKMPHCALPSPSISLYRCSAMPLPIASGGGNGATSGSAANALKRKFARSQGGNAAGAAGAAPPAATASSAATATAASASPSTANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Protein: Arginine-glutamic acid dipeptide repeats protein (Atrophin-2) (Q80TZ9)
Organism: Mus musculus (Mouse)
Function: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival.
Subcellular location: Nucleus, PML body {ECO:0000250}. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs (By similarity). {ECO:0000250}.
Interaction partners:
- Histone deacetylase 1
- Histone deacetylase 2
- Histone acetyltransferase p300
Sequence:
MTADKDKDKDKEKDRDRDRDRERDKRDKARESENARPRRSCTLEGGAKNYAESDHSEDEDNDNNSATTEESNKKSRKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHSSQACCRSPAPAFCDPPACSLPVAPQPPQHLSEAGRGPGGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVSDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESSYDAGKALQRLVKKPVPKLIEKCWTEDEVKRFVKGLRQYGKNFFRIRKELLPSKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPTSPDGRASPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEAASPLKSTKRQREKVASDTEDTDRITSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPSGAASAPSTAPPGTPQLPTQGPTPSATAVPPQGSPATSQPPNQTQSTVAPAAHTHIQQAPTLHPPRLPSPHPPLQPMTAPPSQSSAQPHPQPSLHSQGPPGPHSLQTGPLLQHPGPPQPFGLPSQPSQGQGPLGPSPAAAHPHSTIQLPASQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSLNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQSLPPPAASHPTTGLHQVPSQSPFPQHPFVPGGPPPITPPSCPPTSTPPAGPSSSSQPPCSAAVSSGGSVPGAPSCPLPAVQIKEEALDEAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHSALTIPPAAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL
Protein: General odorant-binding protein lush (O02372)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant-binding protein required for olfactory behavior and for activity of pheromone-sensitive neurons. Binds to alcohols and mediates avoidance behavior to high concentrations of alcohols, the alcohol-binding possibly resulting in activation of receptors on T2B neurons, the activation of these receptors inhibiting these neurons. Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Required for cVA response, probably by binding to VA. May act by serving as an adapter that bridges the presence of gaseous pheromone molecules, cVA, to activation of specific neuronal receptors expressed on T1 olfactory neurons, possibly via a specific conformational change induced by cVA that in turn activates T1 receptors. T1 neurons are excited by the pheromone VA, while T2 neurons are inhibited by alcohols. Also binds to phthalates.
Subcellular location: Secreted {ECO:0000269|PubMed:9755202}.
Interaction partners:
- Pheromone-binding protein-related protein 6
- General odorant-binding protein 83a
- General odorant-binding protein 69a
- Odorant receptor 67d
- IP01303p
- General odorant-binding protein 84a
- Putative odorant-binding protein A10
- General odorant-binding protein 28a
- General odorant-binding protein 19a
- Sensory neuron membrane protein 1
Sequence:
MKHWKRRSSAVFAIVLQVLVLLLPDPAVAMTMEQFLTSLDMIRSGCAPKFKLKTEDLDRLRVGDFNFPPSQDLMCYTKCVSLMAGTVNKKGEFNAPKALAQLPHLVPPEMMEMSRKSVEACRDTHKQFKESCERVYQTAKCFSENADGQFMWP
Protein: Olfactory receptor (Q9QZ22)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
MDRSNETAPLSGFILLGLSAHPKLEKTFFVLILMMYLVILLGNGVLILVSILDSHLHTPMYFFLGNLSFLDICYTTSSVPLILDSFLTPRKTISFSGCAVQMFLSFAMGATECVLLSMMAFDRYVAICNPLRYPVVMNKAAYVPMAASSWAGGITNSVVQTSLAMRLPFCGDNVINHFTCEILAVLKLACADISINVISMVVANMIFLAVPVLFIFVSYVFILVTILRIPSAEGRKKAFSTCSAHLTVVLVFYGTILFMYGKPKSKDPLGADKQDLADKLISLFYGVVTPMLNPIIYSLRNKDVRAAVRNLVGQKHLTE
Protein: Uncharacterized protein YGR237C (P50089)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Mitochondrial carrier protein MTM1
Sequence:
MSSAKTFTKHISFDDLAPSLIDDQATIIKNDSHHVGLNNHFLHIPPQFNPVYKNTLTGSHGSNDLATDESLDSPEDEEASSPLQLGTPTSTTSGVPHFYTQVFSPAAHDPSKSYLRSPSVERSRSESPMFRSRRRTSVRLPPPPKVSVLKKSRKAADEQGPIDDIDIGDLDFELERKMTKMTERNTQKNSGSRKGYTQAAFANLNEVEDRIETKSMVDLSESENMESSKKRSKSFAGMTDEELAKLEEFYISKGRSNKTKIDQFDFGEQVPVYLNTTESKTDSSNVTDPLAAIYPSRPTIVHNAISMTIDHPDYENYISNTKEKLNCKDKDDDVDLRVVSCYISGRRYTWSSVDWYVENLTRNGDHLVIITTIPEFEAKIDTLAYKEKRRHRLERMTSNTSESMTTASHSLIGPDLSSPLSTGIRIEAIHNEAKQTCSDILNYYARRLATKIVRISIEMVKENSTRSAIISATSLYRPSLQVISTVSANIQIKFRNGKVKLPFFLMKHFAMPAFVVPFEFIKPELLIKPRVDKDEQDNSDDLKTEVRKKERLQWLSALIRRTLENPFTKHKVVDSDDEESDSDESVTSVNEYFPISPEKKEEMEFFDKMGYVRPKPSRQVLLDDNTLMKYDSSGRKLTPIESRNSRRSSKRSSRIQFNNNGIYKVKSMVDDIYNHETASTPHIKTALKWDNEDPKMKFTSHPMRKTKSAGLSPRTSSTSSSSGQRKAHHHHHHHNHVSRTKTTESTKSGNSKKDSSSSSTNDHQFKRSEKKKKSKFGSIFKKVFG