wanglab/gogpt-training-data huggingface dataset:
Protein: BTB/POZ domain-containing protein KCTD9 (Q7L273)
Organism: Homo sapiens (Human)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.
Interaction partners:
- Cullin-3
- DNA topoisomerase 2-beta
- DNA topoisomerase 2-alpha
Sequence:
MRRVTLFLNGSPKNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCEGEPFIDPQTDSKPPEGLLGFHTDWLTLNVGGRYFTTTRSTLVNKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLEEARFFGIDSLIEHLEVAIKNSQPPEDHSPISRKEFVRFLLATPTKSELRCQGLNFSGADLSRLDLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKMLCSNAEGASLKLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFEEMLTPLHMSQSVR
Protein: Magnesium transporter ALR1 (Aluminum resistance protein 1) (Q08269)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plasma membrane magnesium transporter.
Subcellular location: Cell membrane {ECO:0000305|PubMed:9430719}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Magnesium transporter MRS2, mitochondrial
- Mitochondrial inner membrane magnesium transporter MFM1
- Manganese resistance protein MNR2
- Magnesium transporter ALR2
Sequence:
MSSSSSSSESSPNLSRSNSLANTMVSMKTEDHTGLYDHRQHPDSLPVRHQPPTLKNKEIAKSTKPSIPKEQKSATRYNSHVDVGSVPSRGRMDFEDEGQGMDETVAHHQLRASAILTSNARPSRLAHSMPHQRQLYVESNIHTPPKDVGVKRDYTMSSSTASSGNKSKLSASSSASPITKVRKSSLVSPVLEIPHESKSDTHSKLAKPKKRTYSTTSAHSSINPAVLLTKSTSQKSDADDDTLERKPVRMNTRASFDSDVSQASRDSQETEEDVCFPMPPQLHTRVNGIDFDELEEYAQFANAEKSQFLASLQVPNEQKYSNVSQDIGFTSSTSTSGSSAALKYTPRVSQTGEKSESTNETEIHEKKEDEHEKIKPSLHPGISFGKNKVEGEENENIPSNDPAYCSYQGTDFQIPNRFSFFCSESDETVHASDIPSLVSEGQTFYELFRGGEPTWWLDCSCPTDDEMRCIAKAFGIHPLTAEDIRMQETREKVELFKSYYFVCFHTFENDKESEDFLEPINVYIVVCRSGVLTFHFGPISHCANVRRRVRQLRDYVNVNSDWLCYALIDDITDSFAPVIQSIEYEADAIEDSVFMARDMDFAAMLQRIGESRRKTMTLMRLLSGKADVIKMFAKRCQDEANGIGPALTSQINIANLQARQDNASHIKNNSSTTVPNNYAPTTSQPRGDIALYLGDIQDHLLTMFQNLLAYEKIFSRSHTNYLAQLQVESFNSNNKVTEMLGKVTMIGTMLVPLNVITGLFGMNVKVPGENSSIAWWFGILGVLLLLAVLGWFLASYWIKRIDPPATLNEAAESGAKSVISSFLPKRNKRFNDRSKNINVRAGPSNKSVASLPSRYSRYD
Protein: Esterase YjfP (EC 3.1.-.-) (P39298)
Organism: Escherichia coli (strain K12)
Function: Displays esterase activity toward palmitoyl-CoA and pNP-butyrate.
Interaction partners:
- Esterase YpfH
- 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
- Pimeloyl-[acyl-carrier protein] methyl ester esterase
- Esterase YqiA
Sequence:
MIEIESRELADIPVLHAYPVGQKDTPLPCVIFYHGFTSSSLVYSYFAVALAQAGLRVIMPDAPDHGSRFSGDAARRLNQFWQILLQSMQEFTTLRAAIAEENWLLDDRLAVGGASMGAMTALGITARHPTVRCTASMMGSGYFTSLARSLFPPLIPETAAQQNEFNNIVAPLAEWEATNHLEQLSDRPLLLWHGLDDDVVPADESLRLQQALSETGRDKLLTCSWQPGVRHRITPEALDAAVTFFRQHL
Protein: LD15160p (Tousled-like kinase, isoform E (EC 2.7.11.1)) (Q1RL19)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPVVKQRKMSRFKMSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS
Protein: Bardet-Biedl syndrome 12 (A0A2R8RT44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Bardet-Biedl syndrome 10.
- Bardet-Biedl syndrome 7 protein homolog
- Bardet-Biedl syndrome 9.
- BBSome complex member BBS2
- BBSome complex member BBS5
- Bardet-Biedl syndrome 1.
- Leucine zipper transcription factor-like 1.
- BBSome-interacting protein 1
- Tetratricopeptide repeat domain 8.
- MKKS centrosomal shuttling protein
Sequence:
MDPSCKQCSFAMKRRHIGLQQLQAITSTAHAFLGPNKRLKFIQDEDAGDAVLIGSCPRLLEHLELDGSVGQLLHETVLAQKKLFHSGTNTLMFLAGAWSRVALECLNRGISVSDIKSAMRGGLQECLDACTQLAVSVEEFKKSDVRSNDQCIDMMVKHSRYINARTKNTQSDDNVQDFRKLSIKSDDQCMDMTHKHSRYANTQTEHAQSDDNVQDFKGSGIKSNDQCMDMTLKHSRYINTKTEHAQSNVNMQDFRKLDDKSDDQCKHMTLKHSRHFNARTKNTQSDVNVQDLKGSDIKSIDQCMDMTLKHSTHFNAQTEHNMQDFRKLDDKSDDQCMYMTLKHSRHFNAQTEHTQSEVTMQDFTKSDIKLDNQSMHMTLKHSRHFNAQTEHTHHDVTVIAQAVSHGCSSMHLLLKAYELQNRAHLDIHNLATCCIPGVSEDHACVLRGYVTLLSVQQTTQVQRLQGRPLNIALINGDLSEKYRHVGFNRPGNIKHITDLFITEESWIENAYKLLHDSSIDVVFVSGVVDVDLKQRCKDVLILEGVKSSVLKHFSTCTGAVPVSYICQLDERRVGRGLRLRKESISGRSDIVSITTDCSVLVTAVICSSVSAKLQMLEDEFWSCAHRLQHALTDGKLLHGAGVTELICIRRLRQYTQLHPDRSPHDSAVLELMSEAWMDFISTVMLNSGSVANRTEAWTSITHQMRRHTDIGVTDGLGVYDNVTVKCEAWRRALDLVFLVLQSDTEIITGVSQGENTYNQLMFL
Protein: Serum amyloid A protein (F1S9C0)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MKLFTGLIFCSLVLGVHSQWLSFLGEAYEGKTHGGDMAPVAYSDMREANFKNSDKYFHARGNYDAAQRGPGGAWAAKVISDARENVQRVTDWLKHGDSGHGVEDSRADQAANEWGRSGKDPNHFRPPGLPDKY
Protein: Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha) (Q9Y4C0)
Organism: Homo sapiens (Human)
Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
Subcellular location: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9CS84}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Neuroligin-2
- Neuroligin-1
- Neuroligin-3
- Leucine-rich repeat transmembrane neuronal protein 2
- Neuroligin-4, X-linked
- Disks large homolog 4
- Neuroligin-4, Y-linked
- Leucine-rich repeat transmembrane neuronal protein 3
- RNA-binding protein Nova-1
- Neurexin-1
Sequence:
MSSTLHSVFFTLKVSILLGSLLGLCLGLEFMGLPNQWARYLRWDASTRSDLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGELQPQRPYMDVVSDLFLGGVPTDIRPSALTLDGVQAMPGFKGLILDLKYGNSEPRLLGSRGVQMDAEGPCGERPCENGGICFLLDGHPTCDCSTTGYGGKLCSEDVSQDPGLSHLMMSEQAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNGKFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTTGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV
Protein: Nonsense-mediated mRNA decay factor (B3DI22)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369098}.
Interaction partners:
Sequence:
MNLCAQYLRQAEALKADMTDSKLGAAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQSQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQSSTSAIVKPQPSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVKTKWSVSDFIKAFIKFHGHVYLCKSLDKLNTLREKLEEQFQRLILQKAFSSQQLVHITVINLFELHHLRDLSNEADEHSYSSDEQISWIQLLGLFMSFLGVMLSRALLNKNREEIMGECPLPAIKVSLDWLRLRPTVFNESAMDKRQYIWPWLVSILNSFQPKEEDVSNASVIPLPEEFELQGFLALRPALRMLDFSKGHQGIVIGKESLLIHARHQRLISLGKWVADNQPRLIQCRISDGLVLFITDIPEIVVEEPQEKDTPVLQESSNGEQTPNESTHGLKSVLSAGKNQNSGLDGSERPVVTFKENIKPREQSREQNRNQNQRDTGKDRAGFNKGNGVQGKNEQKKEGKRKSEVKKNSHDKTTDAGKQVKTQTELRKTPVSEARKTPVTQTQTTCSSQFIPIHHPGAFPPLPSRPGFPPPAYVIPPPVAFSMSPGFTFPTGVSVPAPFLQTASHPQSANPVQTGKPSHIPYSQQRPSGPVALNQGPPQPQQTQPPPPQTSQQALQQSVQLQLQQQQQQQQQQQQQQQQSPTKQSSQLGKSPPHHHSMQQSYMQVPEQPGQMWNQHQNQPGMQKMPMQMPVKQPFFMPTQDPMKLFEHPMSMQPQQPSMDKKMKFPEVKVQDFYWDPPYHMAGEGRSAMADRMGKRQPGVFCSDQENMPRGPPYELPNQSRLDSGADVIGQSSLLPRFSIQDNSYQNNSIFSEAYGKNMTPSSKPDAPMMHQEPSLYSLFEGNPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHSHGSMPFSNFGPIGTPDSRDRRANDRWKAEKTGVSGFGLDYLPSASTSSVPETNSWHQGAPTSTWAAQDMPMEDSSTVLLDSFKSIWSSSMMQPGPSALEQLLMQQKQKQQRGHGNMNPPH
Protein: CD274 molecule (Programmed death ligand 1) (Q4QTK1)
Organism: Sus scrofa (Pig)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MRICSIFTFMAYCCLLEAFTITVPKDMYEVEYGSNVTLECRFPVDKQLNLLALVVYWEMKDKKIIQFVNGEEDLNVQHSSYSQRAQLLKDQLFLGKASLQITDVKLQDAGVYCCLISYGGADYKRITLKVNAPYRKINQRMSLDPVTSEHELTCQAEGYPEAEVIWTSSDYQILSGKTTITSSQREEKLFNVTSTLRVNATTNEIFYCTFRRLGPEENSTAVLVIPEPYVDPARKRTHWVILGALLLLIAVTAIFCLKRNVRMMDVEKCGSRDMKSEKQNDTQFEET
Protein: Leucine-rich repeat-containing protein Bf66946 (C3YZ59)
Organism: Branchiostoma floridae (Florida lancelet) (Amphioxus)
Function: Binds selectively to the Gram-positive bacteria S.aureus and S.pneumoniae. Does not adhere to the Gram-negative bacteria E.coli and S.enterica. Probably recognizes peptidoglycans expressed on the bacterial cell surface.
Subcellular location: Cell membrane {ECO:0000305|PubMed:26821753}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MALRDIFLLSMAMTAVTVQACPSACKCTVSLYGEMVVACGGMGLTEIPEDIPHRAVYLVLKDNNITKITSYSFKGLRNLQGIDLSNNKINHISSAALRHLGHLDDIDLSRNELTSVSEKLFDFPISSAKAQGRRFFVYLANNPWGCDCRMAWLAQELAGGSKTFGDRHMECATPAALAGRGLSEIPQTSFVCTGRDISFDSDGIIATPEESTAFPVAYKVAVVFGCITGLVTILLLVLTAMLYQKRRIRLGSKYELRWNKHPEFV
Protein: Keratin-associated protein 1-1 (High sulfur keratin-associated protein 1.1) (Keratin-associated protein 1.1) (Keratin-associated protein 1.6) (Keratin-associated protein 1.7) (Q07627)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 3-1
- Keratin-associated protein 1-5
- Keratin-associated protein 1-3
- Keratin-associated protein 3-2
- Keratin-associated protein 9-8
- Keratin, type I cuticular Ha3-II
- Keratin-associated protein 11-1
- Keratin-associated protein 2-1
- Keratin-associated protein 7-1
- Keratin-associated protein 8-1
Sequence:
MACCQTSFCGFPSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQTSFCGFPSFSTGGTCDSSCCQPSCCETSCCQPSCYQTSSCGTGCGIGGGIGYGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPSCCQLHHAEASCCRPSYCGQSCCRPVCCCYCSEPTC
Protein: Nonsense-mediated mRNA decay protein 3 (Up-frameshift suppressor 3) (P48412)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in nonsense-mediated decay of mRNAs containing premature stop codons.
Subcellular location: Nucleus {ECO:0000269|PubMed:11502169}.
Interaction partners:
- ATP-dependent helicase NAM7
- Nonsense-mediated mRNA decay protein 2
- ATP-dependent RNA helicase FAL1
- Nonsense-mediated mRNA decay factor EBS1
- Eukaryotic peptide chain release factor GTP-binding subunit
- mRNA export factor MEX67
- RNA annealing protein YRA1
- Eukaryotic peptide chain release factor subunit 1
- 5'-3' exoribonuclease 1
- Nuclear cap-binding protein complex subunit 1
Sequence:
MSNVAGELKNSEGKKKGRGNRYHNKNRGKSKNETVDPKKNENKVNNATNATHNNSKGRRNNKKRNREYYNYKRKARLGKSTENEGFKLVIRLLPPNLTADEFFAILRDNNNDDGDKQDIQGKLKYSDWCFFEGHYSSKVFKNSTYSRCNFLFDNLSDLEKCANFIKTCKFIDNKDNITIPDMKLSPYVKKFTQTSKKDAALVGTIEEDEIFKTFMNSMKQLNENDEYSFQDFSVLKSLEKEFSKSIELENKIAERTERVLTELVGTGDKVKNKNKKKKNKNAKKKFKEEEASAKIPKKKRNRGKKKRENREKSTISKTKNSNVVIIEEAGKEVLKQRKKKMLLQEKLKISNSSQPQSSSAQTQPSFQPKENLFVPRVKILHRDDTKK
Protein: Probable NADH dehydrogenase (Q9I4S0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000320}.
Interaction partners:
- Na+/H+ antiporter subunit E
- Na+/H+ antiporter subunit C
- Na+/H+ antiporter subunit G
- Probable NADH dehydrogenase
- NADH-quinone oxidoreductase subunit C/D
- K+/H+ antiporter subunit F
- Ferredoxin
- Ferredoxin-type protein NapF
- NADH-quinone oxidoreductase subunit I
- NADH-quinone oxidoreductase subunit B
Sequence:
MILALIIALPFMGALLPLLAERGGRTLCAASAGVAPLIGLILLLGQRGTVFAGQTLTASYSWLPEIGINLSLRLDGLGFLFALLILGIGLLVILYARYYLSEQEPMGRFFAFLLLFMGSMLGVVLAENLLLMMLFWELTSLSSFLLIGFWGSRSDARKGARMALTVTGGGGLALLAGVLLLGHIAGSFELTEVLAAGELIRAHALYPLVLILILLGVFTKSAQFPFHFWLPHAMAAPTPVSAYLHSATMVKAGVFLLARLYPALAGTEWFFYLVSLSGLVTLLLGAGMALFQHDLKGLLAYSTISHLGLITLLFGLDSPLSNVAAVFHIINHATFKASLFMAAGIIDHETGSRDMRLINGMWKYLPHTAVLAIVASLAMAGVPLLNGFLSKEMFFGETLSQNLLGSFNWLVPAVATLAGVFSVAYSLRFIHDVFFNGEPARLPKFPPHEPPRYMKVPVEILVFLCLLVGMLPAYTVAPLLAAAASASLGGQLPEYSLAIWHGFNLPLLMSVVALVGGVLVYVLRKPLFNWYAGLPEVDAKLVFEQQVQRVVALAARLTAWLENGSLQRYLAWLLGAALVVVAVELAPLARLTGSRGLTPLDGITALGMLVLAFSGLATALFHRMRLVALLILSVAGLLVALAFARFSAPDLALTQLSVEVVTMVLLMLALYFLPSRTPAESSSLRGLRDVALAGGVGMLVALLAYAVLTRPYESIAGFFVENSVSGGGGYNVVNVILVDFRGFDTLGEISVLAIAGVGIYAMLAGFALHKPTCDPQGRNWAHAKHPLILETLSRVLLPLALLISVFIFLRGHNLPGGGFIAGLVTAIALVLQYIASGSQWVEQRLPLNYAAMAGAGVLIAGLTGLGSWLFGYPFLTSAFGHFELPLIGEIELATAMLFDLGVYLTVVGAALLILSYLGKLSLMPEPVAQEEAL
Protein: Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) (O88444)
Organism: Mus musculus (Mouse)
Function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels. May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina.
Subcellular location: Membrane {ECO:0000269|PubMed:9662407}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P19754}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19754}. Cytoplasm {ECO:0000269|PubMed:24482543}. Membrane raft {ECO:0000250|UniProtKB:P19754}. Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia|. {ECO:0000269|PubMed:24482543}.
Interaction partners:
- Calmodulin-1
- Calmodulin-like protein 4
- Calmodulin-4
- Calmodulin 5
- Calmodulin-like protein 3
- Rap guanine nucleotide exchange factor 3
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Guanine nucleotide-binding protein G
- Rap guanine nucleotide exchange factor 4
Sequence:
MAGAPRGQGGGGGAGEPGGAERAAGPGGRRGFRACGEEFACPELEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCILFLALFVVTNVRSLQVSQLQQVGQLALFFSLTFALLCCPFALGGPARSSAGGAMGSTVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILAALFGLIYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRVQCFPGCLTIQIRTALCVFIVVLIYSVAQGCVVGCLPWAWSSQSNSSLVVLAAGGRRTVLPALPCESAHHALLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTAGTRAKKSISSHLCTLADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLKRCSYQFVCRGKVSVKGKGEMLTYFLEGRTDGNSSHGRTFRLERRMCPYGRGGGQARRPPLCPAAGPPVRPGLPPAPTSQYLSSTAAGKEA
Protein: Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (P30083)
Organism: Rattus norvegicus (Rat)
Function: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P32241}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32241}.
Interaction partners:
- Pituitary adenylate cyclase-activating polypeptide
- Guanine nucleotide-binding protein G
- VIP peptides
- Secretin
- Somatoliberin
- Receptor activity-modifying protein 2
Sequence:
MRPPSPPHVRWLCVLAGALACALRPAGSQAASPQHECEYLQLIEIQRQQCLEEAQLENETTGCSKMWDNLTCWPTTPRGQAVVLDCPLIFQLFAPIHGYNISRSCTEEGWSQLEPGPYHIACGLNDRASSLDEQQQTKFYNTVKTGYTIGYSLSLASLLVAMAILSLFRKLHCTRNYIHMHLFMSFILRATAVFIKDMALFNSGEIDHCSEASVGCKAAVVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSVFITIWTVVRIYFEDFGCWDTIINSSLWWIIKAPILLSILVNFVLFICIIRILVQKLRPPDIGKNDSSPYSRLAKSTLLLIPLFGIHYVMFAFFPDNFKAQVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWSSKSQHPWGGSNGATCSTQVSMLTRVSPSARRSSSFQAEVSLV
Protein: Ribulose bisphosphate carboxylase small subunit, chloroplastic (RuBisCO small subunit) (B3H5S2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000256|HAMAP-Rule:MF_00860}.
Interaction partners:
Sequence:
MASSMLSSAAVVTSPAQATMVAPFTGLKSSAAFPVTRKTNKDITSIASNGGRVSCMKVWPPIGKKKFETLSYLPDLSDVELAKEVDYLLRNKWIPCVEFELEVINTKHGFVYREHGNTPGYYDGRYWTMWKLPLFGCTDSAQVLKEVEECKKEYPGAFIRIIGFDNTRQVQCISFIAYKPPSFTEA
Protein: Cell cycle transcriptional regulator CtrA (Response regulator SokA) (P0CAW8)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Function: Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and class II flagellar biogenesis.
Interaction partners:
- Histidine phosphotransferase ChpT C-terminal domain-containing protein
- Histidine protein kinase DivJ
- Non-motile and phage-resistance protein
- Sensor protein DivL
- Regulator of CtrA degradation
- ATP-dependent Clp protease ATP-binding subunit ClpX
- Sensory/regulatory protein RpfC
- histidine kinase
- histidine kinase
- PopZ
Sequence:
MRVLLIEDDSATAQTIELMLKSEGFNVYTTDLGEEGVDLGKIYDYDLILLDLNLPDMSGIDVLRTLRVAKINTPIMILSGSSEIDTKVKTFAGGADDYMTKPFHKDEMIARIHAVVRRSKGHAQSVIKTGDIVVNLDAKTVEVNGNRVHLTGKEYQMLELLSLRKGTTLTKEMFLNHLYGGMDEPELKIIDVFICKLRKKLAASAHGKHHIETVWGRGYVLRDPNEQVNAA
Protein: Gametogenetin (Q80WJ1)
Organism: Mus musculus (Mouse)
Function: May be involved in spermatogenesis.
Subcellular location: [Isoform 1]: Cytoplasm, perinuclear region. Note=Localizes along the nuclear membrane.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasmic vesicle.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleolus.
Interaction partners:
- Programmed cell death protein 2-like
- E3 ubiquitin-protein ligase FANCL
- Gametogenetin-binding protein 1
- Gametogenetin-binding protein 2
Sequence:
MGNVQSEPSAGGGSRKEQASDRASDSRRTPLVEPEVTPSSPAMRLARGLGVWFPGSSGPPGLLIPPEPQASSSPLPLTLELPSPVTPPPEEAAAVSTPPPPPVGTLLPAPSKWRKPTGTSVPRIRGLLEASHRGQGDPPSLRPLPPLPRQLTEKDPVLRAPAPPPTPLEPRKQLPPAPSTCDPQPLSRRITLASSATSPTESQVRHSSEGQAAGGAHGGVPPQAGEGEMARSATSESGLSLLCKVTFKSGPHLSPTSASGPLAAKASPGAGGGGLFASSGAISYAEVLKQGPQPPGATRPLGEVPPGATRPLGEVPRAAQETEGGDGDGEGCSGPPSVPAPLARALPPPPYTTFPGSKPKFDWVSPPDGTERHFRFNGAVGGIGAPRRRTTTLSGPWGSPPPRSGQTHPSSGPRRPTPALLAPPMFIFPAPNNGEPVRPVPPSPQQIPPLPPPPPTPPATPPPAPPPTPQPPALPRTPILVARPPTPGPGHLESALAPTPPSTLSPTAAADQVPAATPATVTSQVPATATAELSPPMPQPKTRTRRNKGPRAARGVIREEGTSGDGPREPNTAPVTDSSSGGGGGGSNGTSTAGASNKGTARHWPPFEVLNSCPCKCYCRHQRRHRRLPRNVSAWLSTPTNHLSEPPWVATVKLAGSLVAGLEHYDLQATHST
Protein: Modulator of FtsH protease HflC (P0ABC3)
Organism: Escherichia coli (strain K12)
Function: HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:8947034}; Single-pass type II membrane protein {ECO:0000269|PubMed:8947034}.
Interaction partners:
- Modulator of FtsH protease HflK
- ATP-dependent zinc metalloprotease FtsH
- GTPase HflX
- tRNA dimethylallyltransferase
- RNA-binding protein Hfq
- Uncharacterized protein YjeT
- N-acetylmuramoyl-L-alanine amidase AmiB
- High frequency lysogenization protein HflD
- Bifunctional NAD
- Protein translocase subunit SecY
Sequence:
MRKSVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIETVKMLDARIQTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDISQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSAGTEDEVTTPAADNAIAEAAERVTAETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRSQGQEEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFYAFIRSLRAYENSFSGNQDVMVMSPDSDFFRYMKTPTSATR
Protein: Superoxide dismutase (EC 1.15.1.1) (Q6FV67)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Superoxide dismutase
- Candida glabrata strain CBS138 chromosome C complete sequence
- Catalase
- Candida glabrata strain CBS138 chromosome A complete sequence
- Candida glabrata strain CBS138 chromosome J complete sequence
- Candida glabrata strain CBS138 chromosome I complete sequence
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein mL46
- Candida glabrata strain CBS138 chromosome L complete sequence
Sequence:
MLSTSRIAFKSTQLRAASTVLRRTKVTLPELEWDFGALEPHISGQINELHYSKHHQTYVNGLNTAVDQFQELTHKLSKDPNDLQAARDLIQVQQNIKFHGGGYTNHCLFWKNLAPEKNGGGEAPSSSSALGQQIEKQYGSLDKLIEVTNAKLAGVQGSGWAFIVKNLENGGQLDVVQTYNQDTVGNQFVPLVAIDAWEHAYYLQYQNKKVDYFKAIWNVINWKEAAKRYETSKVTK
Protein: Eugenol synthase 1 (ObEGS1) (EC 1.1.1.318) (Q15GI4)
Organism: Ocimum basilicum (Sweet basil)
Function: Catalyzes the synthesis of the phenylpropene eugenol from coniferyl acetate. Phenylpropenes are produced by plants as defense compounds with antimicrobial and antianimal properties, or as floral attractants of pollinators. Eugenol is a characteristic aromatic constituent of spices.
Interaction partners:
Sequence:
MEENGMKSKILIFGGTGYIGNHMVKGSLKLGHPTYVFTRPNSSKTTLLDEFQSLGAIIVKGELDEHEKLVELMKKVDVVISALAFPQILDQFKILEAIKVAGNIKRFLPSDFGVEEDRINALPPFEALIERKRMIRRAIEEANIPYTYVSANCFASYFINYLLRPYDPKDEITVYGTGEAKFAMNYEQDIGLYTIKVATDPRALNRVVIYRPSTNIITQLELISRWEKKIGKKFKKIHVPEEEIVALTKELPEPENIPIAILHCLFIDGATMSYDFKENDVEASTLYPELKFTTIDELLDIFVHDPPPPASAAF