Protein: Unconventional myosin-XV (Unconventional myosin-15) (Q9QZZ4)
Organism: Mus musculus (Mouse)
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles.
Subcellular location: Cell projection, stereocilium {ECO:0000269|PubMed:14610277}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14610277}. Note=Localizes to stereocilium tips in cochlear and vestibular hair cells.
Interaction partners:
- Whirlin
- Epidermal growth factor receptor kinase substrate 8
- Epidermal growth factor receptor kinase substrate 8-like protein 2
- Espin
- Twinfilin-2
- Myosin, light chain 12A, regulatory, non-sarcomeric
- Actin, alpha skeletal muscle
- Espin-like protein
- Myosin-IIIa
- Myosin-IIIb
Sequence:
MADEEKKAKKGKKGKKAPEPEKPKRSLKGTSRLFMGFRDRTPKISKKGQFRSASAFFWGLHTGPQKTKRKKKARTVLKSTSKLMTQMRVGKKKRAMKGKKPSFMVIRFPGRRGYGRLRPRAQSLSKASTAINWLTKKFLLKKAEESGSEQATVDAWLQRSSSRVGSRKLPFPSGAEILRHGGRLRRFPRSHSIYSSGEPVGFLPFEDEAPFRHAGSRKSLYGLEGFQDLGEYYDYHREGDDYYDQQSLYHYEEQEPYLAEFGGYSPAWPPYDDYGYPPGDPYNYYHPDYYGDTLYPGYAYGYGYGYDDFEPPYAPPSGYSSPYSYHDSFESEAYPYSYYLDPYATHHMPYPPYDFPYDTPYDIPYFDPYGVPYAEGVYGGGAEAIYPPGMPYVYPEEPAFMYPWVPPPIMSPHNPYAHPMDDIAELEEPEETGEERQSTSFRLPSAAFFEQQGMDKPARSKLSLIRKFRLFPRPQVKLFGKEKLEVPLPPSLDIPLPLGDAEGEEEEEEMPPVPTMPYTHPYWSFLTPRQRNLQRALSAFGARQGLGFGPEFGHPTPRPATSLARFLKKTLSEKKPIPRLRGSQKARGGRPPVREAAYKRFGYKLAGMDPDRPNTPIVLRRSQPQARNNNNSHGPPSPRPAPRALTHWSALISPPMPAPSPSPASPLTPPFSPTFSRPPRLASPYGSLRQHPPPWAAPAHVPFPPQANWWGFAEPPGTSPEVAPDLLAFPVPRPSFRASRSRSRRAAYGFPSPSLIGSRRRPHLPSPQPSLRSLPGQGYHSPLGPLSPQLSLRRGPFQPPFPPPPRRPQSLREAFSLRRASGRLGPPRSPVLGSPRPPSPPPLLKHGPRHRSLNLPSRLPRTWRRLSEPPTRAVKPWVHRAYPPPPSAGPWGASTGALEQQENQREAEDSETPWTVPPLAPSWDVDMPPTQRPPSPWPEGIGSLRGFSRPPPVPENPLLEHTSPSCEPQSEDRVSNLTGIFLGQHHDPGPGQLTKSADPSLEKPEEVVTLGDPQPPAEPEALNPTPPNKNVVSERKVLRLSASYPLVTCKQARATWPQWHRWKTVSRTPAPLAPTRAPGPLLKAGEQPRAEPGRFAVVMPQVRGVSSFRPKGPAPVQPPEHPDQDPEQGPAPQACSLRWPRLWPPTDAHCLWSRIRTYSSQSHLRGHGGDCHKSLWKKTRPQSWQNKMHSIRNLPSMRSREQHREDGVEDMTQLEDLQETTVLANLKTRFERNLIYTYIGSILVSVNPYRMFAIYGPEQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLILRCLAAMNQRRDVMQQIKILEATPLLEAFGNAKTVRNDNSSRFGKFVEIFLEGGVICGAITSQYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFTSEDQDSIFRILASILHLGNVYFEKHETDAQEVASVVSAREIQAVAELLQVSPEGLQKAITFKVTETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSPKQDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADNQPCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPLPEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYKAHTVAAKFQQSLLDLVEKMERCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVRLPFQVFIDRYRCLVALKLNVPADGDMCVSLLSRLCTVTPDMYRVGISKLFLKEHLHQLLESMRERVQNRAALTLQRYLRGFFIQRHFRSLRRKIILLQSRARGFLARQRYQQMRQSLLKFRSLVHTYVNRRRYLKLRAEQRRRAQEAWLREQEELSKREVVPVRHLEVPAEVAGLLQAAAGLKLSSGPRVAVVRAPRLQAEPCVTLPLDINNYPMAKFIRCHFKEPSFGMLTVPLKMPLTRLPVEHHAEAISVFKLILRFMGDPHLHGTQEMILGNYIVHQGLVEPALRDEILAQLANQVWRNPNAYNSKRGWLLLAACLSGFAPSPHLDKFLLKFVSDYGQNGFQAVCQHRLLQAMGSGAARTFPPTQLEWTAIQEKASMALDVSCFNGDQFSCPVHTWSTGEAVAGDILKHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYFIVGAEGPLAGRGDTRGVFGNCWDSDEDTPTRPQPQDHVAKMPDLDGYCSHKEDGTNGETEAQRWTSNRQAVDSIGESTVPPRELDGYLDSLFDPVLACGDADLEKPTAIAYRMKGGGQPGGGGGSTSEDTSRRPPEPKLKPIPGLDASTLALQQAFIHRQAVLLAREMTLQALALQQQPLSATSRPQLPERPLAPEARPKTVVGTGPPAKPVLVRPTPQSWAPGSVAKAPKIPSKPVAVPILAQDWTAPESISASPELVRYSTLNSEHFPQPTQQIRSIIKQYKQPPWAGHPEARRTDGGKVFRRPPDPHEEALMILKGQKTQLAVVPGTQVSREAVAMVKPVTSAPRPCMGPTPVQPSRSLEPPEDPVQTQLHRLVNPNFYGYQDIPWRIFLRKEVFYPKDNYSHPVQLDLLFRQILHDTFSEACLRISEDERLQMKALFAQNQLDTQRPLVTESVKRAAISMARDSWEIYFSRLFPAMGSVGTGVQILAVSHTGIKLLQMVKGSKEASRRLRVLCAYSFADILFVTMPSQNMLEFNLSNEKLILFSARAQQVKTLVDTFILELKKDSDYVVAVRNFLSEDPELLSFHKGDIIHLQSLEPTRVGYSAGCVVRKKLVYLEELRRRGPDFGWRFGAVHGRVGRFPSELVQPAAAPDFLQLPAEPGRGRAAAVAAAVASAAAAQEVGRRREGPPVRARSADSGEDSIALPPSTMLEFAQKYFRDPRRRPRDGLKLKSKEDRESKTLEDVLCFTKVPIQESLIELSDSNLNKMAVDMFVAVMRFMGDAPLKGQSELDVLCTLLKLCGDHEVMRDECYCQIVKQITDNSSPKQDSCQRGWRLLYIMAAYYSCSEVFYPYLIRFLQHVSWTPGLPFQGIAKACEQNLQKTLRFGGRLEFPSNMELRAMLAGRSSKRQLFLLPGGLERHLKIKTCTVALDVIEGLCTEMALTRPEAFDEYVIFVVTNRGQHVCPLSCRAYILDVASEMEQVDGGYTLWFRRVLWDQPLKFENELYVTMHYNQVLPDYLKGLFSSVPARQPTEQQLQQVSKLASLQHRAKDHFYLPSVREVQEYIPAQLYHTTAGDTWLNLVSQHRQQTQALSPHQARAQFLGLLSAFPLFGSSFFFIQSCSNVLVPAPCILAVNHNGLNFLSTKTHELIVKIPLKEIQSTWTQQPTANSSYPYVEISLGDVAAQRTMQLQLEQGLELCRVVAVHVESMLSAREERLTLPPSEITLL