wanglab/gogpt-training-data huggingface dataset:
Protein: Cholinergic receptor, nicotinic, alpha polypeptide 9 (A0A0J9YUW0)
Organism: Mus musculus (Mouse)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MVYSADADVHGRPRQPQAVETANGKYAQKLFSDLFEDYSNALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVQGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLP
Protein: At2g25250 (Serine/arginine repetitive matrix-like protein) (Q9SIR8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transcription factor bHLH74
- Transcription factor TCP24
Sequence:
MGVAVLHPHDSIINHFSTNTSPPLRHKKPITNRRRRSPSSHQSQISHPPPSPHNHTNHVRILKRGEDINVKIPIEKPDLKSNRQIGSDPMKISTPIRISNRKSMPALFYAGPVTSTSPPPSEVPLPAFFANKTVAGFKPTDATNDLIKILRLDIA
Protein: TATA-box-binding protein-like 1 (EhTRF1) (A7UFC2)
Organism: Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)
Function: TATA box-binding transcription factor. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Bromodomain protein, putative
- TFIIB-type domain-containing protein
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 5, putative
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 2
- TFIID subunit, putative
- Uncharacterized protein
- Transcription initiation factor TFIID subunit 8
- DNA-directed RNA polymerase II subunit, putative
Sequence:
MSSQSSPISLTNNDLEISSNNNKPIIKQLPVPTNEIEKPVIQNIVATVELDCTINLQDVVRRVRNAEYNPKRFGALIIRITNPKTTALVFHSGKLVVTGGKTVDDSRLAGRKYARILQRLGYNVKFNHFKIQNVVASCDMKFAISLKELIQLAPKITKYEPEIFPGVVYRLADPKMVLLIFASGKIVFTGGKEIEQINKAFSEIYKILLQVANNDN
Protein: Inner membrane localized protein (Q9C7S3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 6,7-dimethyl-8-ribityllumazine synthase
- Zinc finger/BTB domain protein
- Alpha/beta-Hydrolases superfamily protein
- Uncharacterized protein At5g03900
- Probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic
- Protein CHLOROPLAST J-LIKE DOMAIN 1
- Mitochondrial substrate carrier family protein
- Ribosomal RNA small subunit methyltransferase J
- Protein RETICULATA-RELATED 4
- Protein FATTY ACID EXPORT 3, chloroplastic
Sequence:
MASLSSTSLSLPKNSHQLHPSSGFSLNPNARCVSVSFGLNHSNKLHISAPRTKRILTIQSAYRDDDGSGSTGLFVGGFILGGLIVGALGCVYAPQISKAIAGADRKDLMRKLPKFIYDEEKALEKTRKVLAEKIAQLNSAIDDVSSQLKSEDTPNGAALSTDEIEATA
Protein: Bcl2l12 protein (Q8CHQ5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAGSEELGLREDTLKVLTAFLKRGEVAGSPVPTPPRSPAQEETTDFLSRLRRCLPCPLGRGAPPTESSRPHFLPLRPCYGSEPGPASSEFYALVAQRLEQLVQEQLKSPPSSEFQGPPPTEKEALLRRLVALLEEEAEVINQKVTSLYSTLWRGQLWNRGQTLALLCFDAGCGSRAPVNIRASSQEP
Protein: RNA polymerase sigma factor SigI1 (A3DBH0)
Organism: Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity). This sigma factor is involved in regulation of cellulosomal genes via an external polysaccharide-sensing mechanism. SigI1 promotes transcription from sigI1 and celS promoters.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02064}.
Interaction partners:
- Anti-sigma-I factor RsgI1
- Anti-sigma-I factor RsgI4
- Anti-sigma-I factor RsgI7
- Anti-sigma-I factor RsgI5
- Anti-sigma-I factor RsgI2
- Anti-sigma-I factor RsgI3
- Negative regulator of flagellin synthesis
- Anti-sigma-I factor RsgI8
Sequence:
MEVRKINTHNREKKLDDIVYDDFISTLRQIKEGNHQLREEFISEYKPFILKVTSNATGKYIDTRNSDEFSIALSAFNEAIDKFDIEKGYNFFLFSEQVIRRRLIDYSRSNKDDKEYPFSFFDDEYFYNNEKLLSKSYIGFEDIEAREDIEELKKKLQEFGITFLDLVLNVPKHRDSRQLCIRLAKMLAEDEQMYNALMKNKNIPRNELKKKAKVHGRTIGNNRKYIIALCLIFRSNLNLSKRYLEYYTMDGESDLI
Protein: LP14662p (Reduced mechanoreceptor potential A, isoform C) (Q9VPR0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
Sequence:
MIVWGEPQRDVTYPVHATSQATALCWHPEKALLASGWEHGDIHVWFAGHREFASVNAPHKAAIVLLQFSEQGGRMVTADAMGLVTGWRCDGQYQFLTMFSHDLREVLLLICFRLTVESEVREEMANLAKAAVAGDENALDTLTNWRPRTAARSMTHSGVRDNHCFYACTQGGVVYYINQGGACVEVMKCGSLPPIVQMLWHPRKDAVICLMEDLTVTLFLVESTGILTELDRVKMSGRGGGRQGGIAWSGNSLAIITGDFFVRIWDIERSDNYLLKMDLPSGNQPGSSMTTLSNGTMSSSNQFFSHDSSESSGVLRKTPKYGQLNGEMFTCLAYSSTGQTLCAGTSQGNVYTWKRSGSRLVGAPEDAWQLTNISSVRGAIRSCEWGYNELAKPCMLVNCLSNVFMLKEQPLLAVHTRELWAVQRSAKSVQLTHCSGREAIVQSEFAVTAMALSELSLVMSNGRSISSYSLQKVEKSLDEFEEILQTVEGTTPTTESTTTPLSLKLLQTFAAECLALNLCNQNIFCLGSSDVFVYSVGGVVLHRIQASDIEGKIIGMDLSGCYLSVFTMNGYVKAYDVSRHDPKLLFPSKSGHDIFDDFGEFILVKCNSSGSHLAMVIASSNFTPISTLFCWDFERSNLLEYGLLEPETNAKKESSTSLPVRIFWDAEEPRLLATEVKSMIQKTLPQKNSLQPSHFVQSKVVLLFYSEKGCLNVLETQSMSPGCQLLNLCVPNVIRLKINTMEEQPLQDFVDLQQCNPVTRKQVLNFSLYVAEGNMDMAYRSIRSIQSKVIWTNLAKMCVHTNRLDVAKVCMGHLEQARSVRALRQAIEDDDLETEAKVAVLAIELGMIEEAKDLYRRCKRFDLLNKLLQSIGHLDEAVELAEAEDRIHLKHTYYQKAQELRERGDIKGALEYFEKTQNPAQNITQLLLENPGAMKRYIQTTSDPKLLKWWGQYIESSGDMDAALAVYHKAEDWFSQVKILCYLGKISKADAIARQSGDRAACYHLARHYENVGKFQEAIMFFTRAQTFSNAIRICKENDFQEELWTVASSSRQRDKAIAAAYFEECGNFKHAVELYHRAGMLHKALEMAFESQQPEILEIIASDLAPDSDAELINRCADFFCSIEQFQKAVHLLAKTRHLERALGICSEKGVPVTEELSEMLTPEKGEFEEATRVHILVQLGEFLQQQGDYHSATKKFTQAGDKIRAMKSLLKSGNTDKIIFFANMSRQREVYIMAANYLQALDWQSDPQVLKHIVTFYTKGQAFDSLANFYAICAQIEIEEFQDYGKALTAMQEASKCLEKLSHAQHVYNNLQRTVADVKAILEIQQALREGDHQLVIGSCRSMLIKPELPPIRHAHILAMLIRALVYVKDYSEAGRALKELTVKDSTWSASGLLDRSIVHKIAQECHLEFDLIWNAGRQVTASTSGTAATGMSSTSGMTTTDDDDADDEEITEELH
Protein: Hydroxysteroid 11-beta-dehydrogenase 1-like protein (11-beta-hydroxysteroid dehydrogenase type 3) (J3KTC8)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
XLGALFFAYYWDDNFDPGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVR
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (G3V2G1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MESIFHEKQPSGNMDDSGFFSIQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSD
Protein: Pectate lyase (EC 4.2.2.2) (Q9RHW0)
Organism: Bacillus sp
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU367009}.
Interaction partners:
Sequence:
MKKLLGLILSAALTLSLYGLEPQVAEAAPTVVHETIRVPAGQTFDGKGQTYVANPNTLGDGSQAENQKPIFRLEAGASLKNVVIGAPAADGVHCYGDCTITNVIWEDVGEDALTLKSSGTVNISGGAAYKAYDKVFQINAAGTINIRNFRADDIGKLVRQNGGTTYKVVMNVENCNISRVKDAILRTDSSTSTGRIVNTRYSNVPTLFKGFKSGNTTASGNTQY
Protein: Sdcbp protein (Syndecan binding protein) (Syndecan-binding protein (syntenin) 2) (Syntenin-2) (Q803J6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Tetraspanin
- Tetraspanin
- Tetraspanin
Sequence:
MSLYPSLEDLKVDKVIRAQSQFANATSSTPAITQGAYQPQPATQGMPSSTLYPNLEELGDYMGLSLNSDEVQRNLALVPVATQVAVPSSVGGMVRPVTGADMGIRRAEIRPGLREVILCKDQEGKVGLRLRDIDNGVFVQLVQANSPAALAGLRFGDQVLQINGQNVAGWNSDKAHKALKAAAEQRIELIVRDRPFQRTITMHKDSSGHVGFIFKSGRITSLVKDGSAARNGLLTEHYICEINGQNVIGLKDTQIKDILTTSPTAMTITIMPKFIFEHMIKKMSGGLLKSSMDHSVPEV
Protein: Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (hSVCT1) (Yolk sac permease-like molecule 3) (Q9UHI7)
Organism: Homo sapiens (Human)
Function: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10631088, ECO:0000269|PubMed:19379732, ECO:0000269|PubMed:36749388}; Multi-pass membrane protein {ECO:0000269|PubMed:19379732}.
Interaction partners:
- Uridine 5'-monophosphate synthase
- Matrin-3
- Trifunctional purine biosynthetic protein adenosine-3
- Vesicle transport protein GOT1A
- Vesicle transport protein GOT1B
- Metastasis-suppressor KiSS-1
- Dihydropyrimidine dehydrogenase [NADP
- Dihydroorotate dehydrogenase
Sequence:
MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSSLKSYDFPIGMGIVKRITFLKYIPICPVFKGFSSSSKDQIAIPEDTPENTETASVCTKV
Protein: Platinum sensitivity protein 3 (Q12318)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for resistance to the DNA-damaging agents methyl methanesulfonate (MMS), cisplatin and oxaliplatin, but not to mitomycin C. Plays a role in protection against mutation accumulation. May be a component of the recombination-repair pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:15654096}.
Interaction partners:
- Suppressor of hydroxyurea sensitivity protein 2
- Suppressor of HU sensitivity involved in recombination protein 1
- Chromosome segregation in meiosis protein 2
- ATP-dependent DNA helicase SRS2
- DNA repair protein RAD4
- DNA repair protein RAD2
- ATP-dependent helicase SGS1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- DNA repair protein RAD55
- ARS-binding factor 1
Sequence:
MEVLKNIRIYPLSNFITSTKNYINLPNELRNLISEEQESKLGFLHIIESDFKPSVALQKLVNCTTGDEKILIIDIVSIWSQQKQRQHGAIYMNSLSCINITGLIVFLELLYDSPMDALRRCQVDNFNFQLRGIVIDNLSFLNFESDKNYDVINLSKFEKLFKILRKLREFLGCWIITKSFPTDFYNGIENTLVDKWSIKRKSGVTLYPTKLPDSYMKGMDLIIYREVVDGRPQYRRIAALEE
Protein: DyNactin Complex component (Q965K5)
Organism: Caenorhabditis elegans
Interaction partners:
- Dynactin subunit 5
- Dynactin subunit 4
- Probable dynactin subunit 2
- Dynactin subunit 6
- Actin-related protein 10
- Dynactin subunit 1
- Actin
- F-actin-capping protein subunit alpha
- F-actin-capping protein subunit beta
- Fatty-acid and retinol-binding protein 1
Sequence:
MDMIELEKKISEIEEVLGIDDLTTKTSIPSQIEALQSKLRDDCKANLLMSIPIQKLEHLSKIATETSGPYGSLTDKIESVKYAEKLINERAERIKQFSDALEPCLDQELFSKVAALQPELDAEIEKYEKALEDWTKTYGEFQTLVAERSMINQKITEKVLDLQTKINAKAK
Protein: 2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (3-deoxy-D-manno-octulosonic acid 8-phosphate synthase) (KDO-8-phosphate synthase) (KDO 8-P synthase) (KDOPS) (Phospho-2-dehydro-3-deoxyoctonate aldolase) (Q9ZFK4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
- Arabinose 5-phosphate isomerase KdsD
- 3-deoxy-manno-octulosonate cytidylyltransferase
- UDP-3-O-acyl-N-acetylglucosamine deacetylase
- Tetraacyldisaccharide 4'-kinase
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- UDP-3-O-acylglucosamine N-acyltransferase
- Lipid-A-disaccharide synthase
- 3-deoxy-D-manno-octulosonic acid transferase
- CTP synthase
Sequence:
MAQKIVRVGDIQIGNDLPFVLFGGMNVLESRDLAMQVCEEYVRVTEKLGIPYVFKASFDKANRSSIHSFRGPGLEEGMKIFEEIKKTFKVPVITDVHEPFQAQPVAEVCDIIQLPAFLSRQTDLVVAMARTNAVINIKKAQFLAPQEMKHILTKCEEAGNDRLILCERGSSFGYNNLVVDMLGFGIMKQFEYPVFFDVTHALQMPGGRADSAGGRRAQVTDLAKAGLSQKLAGLFLEAHPDPEHAKCDGPCALRLNKLEAFLSQLKQLDELIKSFPAIETA
Protein: Start control protein cdc10 (P01129)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Major component of the cell cycle transcription factor complex MBF (MCB binding factor, also known as DSC1), that controls G1-S phase specific gene expression. Involved in the control of rRNA production, via interaction with pol5. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. In fission yeast, two genes, cdc10 and cdc2, are required for the cell cycle control called start, the point early in the G1 phase at which cells become committed to the mitotic cycle.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00630, ECO:0000269|PubMed:10759889}.
Interaction partners:
- Cell division cycle-related protein res2/pct1
- Cell division cycle-related protein res1/sct1
- Cyclin-dependent kinase 1
- Transcriptional activator protein rep2
- Origin recognition complex subunit 5
- Spindle assembly checkpoint protein bub3
- Mitogen-activated protein kinase spm1
- MBF complex negative regulatory component yox1
- G2/mitotic-specific cyclin cdc13
- Cell division control protein 18
Sequence:
MASANFIRQFELGNDSFSYQKRPEDEPSQPLSNRNINKLNDSSTLKDSSSRIFINSQVLRDGRPVELYAVECSGMKYMELSCGDNVALRRCPDSYFNISQILRLAGTSSSENAKELDDIIESGDYENVDSKHPQIDGVWVPYDRAISIAKRYGVYEILQPLISFNLDLFPKFSKQQQIESSSISKNLNTSSFNTRSPLRNHNFSNPSKSSKNGVHTINNMQSSPSPSSSFLLPLTQIDSQNVKRSNNYLSTSPPILEQRLKRHRIDVSDEDLHPSSQLNDNEASSLFPDTPRLNHSLSFVSLVSSLPPLDQNIMQDYHTSKDILTSIFLDVNFADSSALEAKLSDSLDLDVPIDELGHAALHWAAAVAKMPLLQALIHKGANPLRGNLTGETALMRSVLVTNHLNQNSFGDLLDLLYASLPCTDRAGRTVVHHICLTAGIKGRGSASRYYLETLLNWAKKHASGNNGYMLKDFINYLNHQDKNGDTALNIAARIGNKNIVEVLMQAGASAYIPNRAGLSVANFGIFVENALKQPEDSKQTKVSLMSENLSSKEKTAVPPRQKSRDIIASVTDVISSLDKDFQDEMAAKQSMIDSAYTQLRESTKKLSDLREQLHVSETQRTLFLELRQRCKNLMTSIEEQKSELSNLYESFDPNGIHDSLSLDADAPFTVNENNNKNLSIAELKFQVAAYERNEARLNELANKLWQRNSNIKSKCRRVVSLCTGVDESRVDSLLESLLQAVESDGQQGEVDMGRVAGFLRVVKEHQA
Protein: IP19013p (IP19019p) (IP19313p) (IP19619p) (A9UN61)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- IP19120p
- RE05851p
- FI16876p1
- Uncharacterized protein, isoform B
- Mucin 4B, isoform B
- Uncharacterized protein
- Uncharacterized protein
- IP19005p
- MIP13722p
- Chorion protein S16
Sequence:
MFERCNLLFMTMLMASALLTQAHFPEYCAECEQEVWEQVPCSEVPTTVAPTTTGGSTLSPPTTSATSPGPIYPTTTSAPPTPTDYTTQPSEYKKCYCECKLGCKEFCRKVISSEPKQPLTQISSIGEYAPGGQVEYTHVHQRKYFPKYGGESYGGLVGPVGGPKAYKPYPLVYEQAASAASPASIPSVASSPAVASIAAPNYTLEELAQLLSTAYGTKKGYPASVPTPPRIQLQPAPSVFYSPVPSYKKQVVPLVSKVAPAPKISSSIKYAASAVSSSSSGVSVAKIKTPYEEKIVVATPSPIYERSTSYPIVEAPKEYSAPQTEVYPVVQSQTESYPSHTPIYPSPTESYPSQKDSYPSITESYPSQTESYQPRTEAYPVPQPEIKPYGGPDSGPDKPSSTFDLAIDNYLKDFGYGNQGRGYADY
Protein: DNA replication licensing factor mcm7-B (EC 3.6.4.12) (CDC47 homolog B) (CDC47-2p) (Minichromosome maintenance protein 7-B) (xMCM7-B) (Q7ZXB1)
Organism: Xenopus laevis (African clawed frog)
Function: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q91876}. Chromosome {ECO:0000250|UniProtKB:Q91876}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250|UniProtKB:Q91876}.
Interaction partners:
Sequence:
MPRDYQAEKEKCKTFLQEFYKDDEFGKKNFKYGVQLANIAHREQVALCIDLDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMMEQRGRDPNEMRDPHNQYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQTRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVGITGVFLPMLRTGFRQVVQGLLSETYLESHRLVKMNKTEDDELGTEELSEEELRQITEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDHSPRGMKIRGNINVCLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDSDRTAIHEVMEQQTISIAKAGIMTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAQHITYVHQHSKQPPSQFQPMDMKLMRRYITMCKSKQPAIPESLADYLTAAYVEMRKEARTNKDMTFTSARTLLSILRLSTALARLRLEDVVEKEDVNEAMRLTEMSKDSLQGDKGHASRTQRPADVIFSTIREMVPEKGARSVKYSEAEQRCVSKGFTPAQFEAALEEYEELNVWLVNQARTKITFV
Protein: Nuclear distribution C, dynein complex regulator (A0A0A0MSS4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEKLITQTFSHHNQLAQKTRREKRARQEAERREKAERAARLAKEAKSETSGPQIKELTDEEAERLQLEIDQKKDAENHEAQLKNGSLDSPGKQDTEEDEEEDEKDKGKLKPNLGNGADLPNYRWTQTLSELD
Protein: Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) (Q86UE4)
Organism: Homo sapiens (Human)
Function: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus. {ECO:0000250}.
Interaction partners:
- Staphylococcal nuclease domain-containing protein 1
- BRCA2 and CDKN1A-interacting protein
- Protein argonaute-2
- Dihydropyrimidine dehydrogenase [NADP
- Thymidylate synthase
- Fragile X messenger ribonucleoprotein 1
- Alpha-globin transcription factor CP2
- Cysteine-rich secretory protein 3
- Large ribosomal subunit protein uL4
- RAC-alpha serine/threonine-protein kinase
Sequence:
MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET
Protein: Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase IV-related protein 3) (DPRP-3) (Dipeptidyl peptidase X) (DPP X) (Dipeptidyl peptidase-like protein 2) (DPL2) (Q8N608)
Organism: Homo sapiens (Human)
Function: Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q6NXK7, ECO:0000269|PubMed:14566338}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P42658}.
Interaction partners:
- A-type voltage-gated potassium channel KCND2
- A-type voltage-gated potassium channel KCND3
- IgLON family member 5
- Leucine-rich glioma-inactivated protein 1
- Contactin-associated protein-like 2
- Voltage-gated potassium channel KCNC1
- PHD finger protein 11
- Paraneoplastic antigen Ma2
- Disintegrin and metalloproteinase domain-containing protein 33
- Metabotropic glutamate receptor 5
Sequence:
MNQTASVSHHIKCQPSKTIKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE
Protein: ACP53C14B (Q6GUS0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSVIKSIFLLSILAVCLIPWETEAQATISESWGRLGKCTQVAIETLTSLADKIVPTVYELKQCSGYVTLEPANGKDRKITWYLKVSYEFFKKLVFDEPKCLHGLLNKLAATIKPFAEQISGLGCLDEEDYII
Protein: Chaperone protein ClpB1 (ATP-dependent Clp protease ATP-binding subunit ClpB homolog 1) (Casein lytic proteinase B1) (Heat shock protein 101) (Q6F2Y7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Molecular chaperone involved in heat stress response. May play a role in resolubilization of protein aggregates after heat shock.
Subcellular location: Cytoplasm, cytosol. Nucleus {ECO:0000305}.
Interaction partners:
- Os08g0432500 protein
- 18.0 kDa class II heat shock protein
- 23.6 kDa heat shock protein, mitochondrial
- 19.0 kDa class II heat shock protein
- Heat shock protein 81-2
Sequence:
MNPDNFTHKTNEALVAAHEIASEAGHAQLTPLHLVAALAADKGGILRQAISQASGGDAGAPDSFERVVSGALKKLPSQSPPPDSVPASTALIKVIRRAQSAQKKRGDSHLAVDQLLLGLLEDSLISDCLKEAGVSAARVRAELEKLRGGEGRKVESASGDTNFQALKTYGRDLVEQAGKLDPVIGRDEEIRRVVRILSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVRGDVPSNLLDVRLIALDMGALVAGAKYRGEFEERLKAVLKEVEEAEGKVILFIDEIHLVLGAGRTEGSMDAANLFKPMLARGQLRCIGATTLEEYRKYVEKDAAFERRFQQVFVAEPSVPDTISILRGLKEKYEGHHGVRIQDRALVVAAQLSARYIMGRHLPDKAIDLVDEACANVRVQLDSQPEEIDNLERKRIQLEVEHHALEKEKDKASKARLVEVKKELDDLRDKLQPLTMKYRKEKERIDEIRKLKQRREELQFTLQEAERRMDLARVADLKYGALQEIDVAIAKLESETGENLMLTETVGPEQIAEVVSRWTGIPVTRLGQNDKERLVGLADRLHQRVVGQAEAVSAVAEAVLRSRAGLGRPQQPTGSFLFLGPTGVGKTELAKALAEQLFDDENLLVRIDMSEYMEQHSVARLIGAPPGYVGHEEGGQLTEQVRRRPYSVILFDEVEKAHVAVFNTLLQVLDDGRLTDGQGRTVDFRNTVIIMTSNLGAEHLLAGMVGKNSMKVARDLVMQEVRRHFRPELLNRLDEIVIFDPLSHEQLRKVARLQMKDVAVRLAERGVALAVTDAALDVILSLSYDPVYGARPIRRWIEKRVVTQLSKMLIQEEIDENCTVYIDAAPHKDELAYRVDNRGGLVNAETGQKSDILIQVPNGAATGSDAAQAVKKMRIMEDEDGMDEE
Protein: ABC-type antigen peptide transporter (EC 7.4.2.14) (Q8IA64)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSSSLYTGGQALFICLAFIGLDLLVNVFGLAWNGKYFTFDNIAHWFDLANYSFLKNPVDFLAVALIRDSILLGGAVSAWASPSGFSQVAENVKNVVFAMMLLIVAFAPSKLLAFYEDDNIRLAVGDWILMIWCIFASLLLQGIWTSVLAHVTEVAAGTGDSLLFGDAEHEERLRQEEAEKAAEQRETFQLLFRLLGYMGRQWKYYGMAFFFLFCYSLSRVFIPYYTGEVVTAVFGDKASYEKLHKTVFIMGMLSLASTVFGGLRGGSFTYAHATIDRQIRNDLFRSVVKQEIGFFDMNKTGEICSRLSADCQTMSNTLSLYMNVLTRNLTMLFGSLIFMFTLSWKLSMITLINIPIIFLVNKIFGVWYDMLSEETQNSVAKANDVAEEVLSSIRTVKSFACENYESSRFMTFLNVTLKIATRKVFVVIGLIWSNELLQMGILTIVLWYGGHLVIENKVESGLLVSFLLYQFQLGENLRELGEVWNGLMQAVGASRKVFEFIDRPPRVENTGTYAPDGMTGKIEFRHVAFSYPIRPDLPIMEDLTFTVEPGEVVALVGPSGGGKSSCIAMLEHFYEPTSGEVLIDGVPVREYDHKFLHTKVALVGQEPVLYARSVTENIGYGLDKYDDDMVQNSAKLANAHTFIMNDTTDGYNTNVGEKGSQMSGVYSNSLKFKL