wanglab/gogpt-training-data huggingface dataset:
Protein: Histone-lysine N-methyltransferase set-25 (EC 2.1.1.-) (EC 2.1.1.366) (Histone H3-K9 methyltransferase set-25) (G5EEU2)
Organism: Caenorhabditis elegans
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate. Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina. Required for small-RNA-induced H3K9 methylation. Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription-induced replication stress through methylation of H3K9.
Subcellular location: Nucleus {ECO:0000269|PubMed:22939621}. Chromosome {ECO:0000269|PubMed:22939621}. Nucleus lamina {ECO:0000269|PubMed:22939621}. Note=Colocalizes with its own product and hpl-1 in foci in the peripheral region of the nucleus, in a manner dependent on H3K9me3. {ECO:0000269|PubMed:22939621}.
Interaction partners:
- Chromo domain-containing protein.
- Chromobox protein homolog hpl-1
- Chromo domain-containing protein cec-4
- DNA damage-binding protein 1
- Argonaute protein hrde-1
- Histone-lysine N-methyltransferase mes-2
- Nuclear exosome regulator NRDE2
- Lysine-specific histone demethylase 1
- Chromo domain-containing protein cec-3
- Cullin-4
Sequence:
MLPAWGTSTEATASHAGWDGDDEGDIRAAYTEDEKKENIPPISLTSVSTNGAYPGQKRRRSESVRTLKPECPPEETQRLRQRRRISATDATQSSRTMNVIEDRKPRVNRARKSQDAPSTSTCGFETPVGTKRKSKAADSQKPPKQSKLRKIDEASTSKAVDNSSKDGKKTTKPAVTQSNRRRSGLSLRPVPIETIFSESSGRESSTEDEADVSHQQRVEKIAKNPIMVVVLPLGPGNYPNNERITVVSTYKSRVNKNCNEARRAQRHGSWSRKGIAFPGIPTKKFTKSDLAKYGAHASNWPAQAAFRSEEGKILIYYEGWTCLTLHRLSVEECARTAPTILEEMSIRDKFIETVKSAAAEEAKLVVEKNQENGIELTLDEALKQIFIEPVPQSSPENVFWIYQDLSYFHTMDNRDLGLAPVFYISSYTQSVRPPCYAYTAINIVDVDAYKRCLESRANMSFADLTGQKIWMPTRSKACENGTKCKCDARFMFLYDPHDVTNLECTPDGKVDFTDFKIDNARIVMECSDACGCSLDCPRRSLQRGQQHPLAVYYEGPEKGFGVRAAANIKAGELVCEYTGDVTLLPTSDPVASSSTKTDDGEEQENPEAPERVDSSYDAAFNAMDTKIIISAKKTGNISRFINHSCDPSSVFVEVYSRRFEEDPLIPRVAVYAIKDIALGEEITIAYYEPGIEWKRSSVKCRCKSTKCMGTLPAF
Protein: WD-40 repeat protein (Q9XYF7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRPPEFKLNNPPEDLISAVKFGPKSNQYMAASSWDGTLRFYDVPANQLRQKFVQDAPLLDCAFMDIVHVVSGSLDNQLRLFDVNTQAESIIGAHEEPIKCLEHAEYVNGILTGSWDNTVKLWDMREKRCLGTFEQNNGKVYSMSVIDEKIVVATSDRKVLIWDLRKMDSYIMKRESSLKYQTRCIRLFPNKEGYVMSSIEGRVAVEYLDHDPEVQRRKFAFKCHRNREQNIEQIYPVNALSFHNVYQTFATGGSDGIVNIWDGFNKKRLCQFQEYDTSISTLNFSSDGSALAIGCSYLDQLPETPATVPHPAIYIRYPTDQETKQK
Protein: Actin (O45815)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Profilin-2
- Profilin-1
- Actin-depolymerizing factor 2, isoform c
- Profilin-3
- Alpha-actinin, sarcomeric
- Vinculin
- Gelsolin-like protein 1
- Calponin-homology
- FERM domain-containing protein
- Myosin regulatory light chain
Sequence:
MEEEIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRIAPEEHPVLLTEAPLNPKSNREKMTQIMFETFNTPAMYVNIQAVLSLYASGRTTGIVLDTGDGVTHTVPIYEGYALPHAIQRLDLAGRDLTDYMMKILTERGYTFTTTAEREIVRDIKEKLCYVAHDFESELAAAASSSSLEKSYELPDGQVITIGNERFRCPEVLFQPAFIGMEGAGIHETTYQSIMKCDVDIRKDLYANTVLSGGTSMFPGIADRMQKEIQHLAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
Protein: NAD-dependent histone deacetylase sirtuin-1 (EC 2.3.1.286) (Silent information regulator 2) (Q9VK34)
Organism: Drosophila melanogaster (Fruit fly)
Function: NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12086602}. Nucleus {ECO:0000269|PubMed:11281647, ECO:0000269|PubMed:12086602}. Chromosome {ECO:0000269|PubMed:12086602}.
Interaction partners:
- Forkhead box protein O
- FI18188p1
- Circadian locomoter output cycles protein kaput
- NAD-dependent protein deacetylase Sirt7
- Nicotinamide-nucleotide adenylyltransferase
- Autophagy protein 5
- Ubiquitin-like modifier-activating enzyme ATG7
- Histone deacetylase HDAC1
- Autophagy-related 8a, isoform A
- Protein cycle
Sequence:
MMENYEEIRLGHIRSKDLGNQVPDTTQFYPPTKFDFGAEILASTSTEAEAEAEATATTTEPATSELAGKANGEIKTKTLAAREEQEIGANLEHKTKNPTKSMGEDEDDEEEEEEDDEEEEEDDEEGITGTSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGDSDVIINQICHRLSDNDDCWRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIKSNSSADYILGSAGTCSDSGFESSTFSCGKRSTAAEAAAIERIKTDILVELNETTALSCDRLGLEGPQTTVESYRHLSIDSSKDSGIEQCDNEATPSYVRPSNLVQETKTVAPSLTPIPQQRGKRQTAAERLQPGTFYSHTNNYSYVFPGAQVFWDNDYSDDDDEEEERSHNRHSDLFGNVGHNYKDDDEDACDLNAVPLSPLLPPSLEAHIVTDIVNGSNEPLPNSSPGQKRTACIIEQQPTPAIETEIPPLKKRRPSEENKQQTQIERSEESPPPGQLAAV
Protein: Slc18a2 protein (Q5CZP4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
GSNTSQATKKLRIQRAFHPGSDSKAQCKCAYKVISPSLSGSWIFIFKMGLFDALRDFSLLTWLREERQSRRLILLIVFIALLLDNMLLTVVVPIIPSYLYTVDDEAAQMVKNHSMTPLSPSSTFQSIVSLYDNTTRVTGFSPQMSTAGPMSLAPTFVSPQNQSDCPKADDQLLNENVKVGLLFASKATVQLITNPFIGPLTNRIGYQIPMFAGFCIMFVSTIMFAFSSSYTLLFLARSLQGVGSSCSSVAGMGMLASVYTDDEERGNAIGIALGGLAMGVLVGPPFGSVMYEFVGKTAPFLILAVLAVLDGALQLFVLQPSKVEPESQKGTSLITLMKDPYILIAAGSICFANMAIAMLEPALPIWMMETMCPRKWQLGIAFVPASISYLIGTNIFAVLAHKMGRWLCSLIGMLLVGISILCVPLAKDIYGLIVPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGFALGPSAGGAIARSIGFPWLMTIIGLVDIMFAPLCFFLRNPPANEEKMAILMDSNCSMKTRSYSTQGSSYQMGDDFDPESPE
Protein: DNA/RNA-binding protein Alba-like domain-containing protein (Q385X1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA/RNA-binding protein Alba-like domain-containing protein
- DNA/RNA-binding protein Alba-like domain-containing protein
Sequence:
MTTGKSDRPRNSVRVGYRGTKFLFVDITKHLLHDGEKEVYVSALGGAINEAVSVVEMLKDQQMVVVKKITTSRQVSEEPDDGPVDKIEIVVTKADGFDAKYEEQQKAREAKRLEKEKNEKEKATA
Protein: Voltage-dependent calcium channel subunit alpha-2/delta-3 (Voltage-gated calcium channel subunit alpha-2/delta-3) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3] (Q8CFG5)
Organism: Rattus norvegicus (Rat)
Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Voltage-dependent R-type calcium channel subunit alpha-1E
- Voltage-dependent L-type calcium channel subunit beta-2
- Oxytocin receptor
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Voltage-dependent calcium channel gamma-1 subunit
- Voltage-dependent L-type calcium channel subunit beta-4
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Voltage-dependent L-type calcium channel subunit beta-1
- Voltage-dependent L-type calcium channel subunit alpha-1S
Sequence:
MAGPGSLCCASRGASALLATALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNVLSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPERKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLADDQGLVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGAPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKARDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGTVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGLLDPYKAFLSAAKWIVTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPEENARECGGASSLQAQVALLLLPLVSSLFSR
Protein: Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC) (O75078)
Organism: Homo sapiens (Human)
Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress (By similarity). Plays a role in spatial learning and motor coordination (By similarity). Involved in the nociceptive pain response to chemical-derived stimulation (By similarity).
Subcellular location: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9R1V4}; Single-pass type I membrane protein. Perikaryon {ECO:0000250|UniProtKB:Q9R1V4}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V4}. Note=Localizes to basket cell terminals and pinceaux. {ECO:0000250|UniProtKB:Q9R1V4}.
Interaction partners:
- Leucine-rich glioma-inactivated protein 1
- Leucine-rich repeat LGI family member 4
Sequence:
MRLLRRWAFAALLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA
Protein: Beta-arrestin 2 (A5J090)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MGERAGTRVFKKSSPNCKLTVYLGKRDFVDHLDRVDPVDGVVLVDTDYLKDRKVYVTLTCAFRYGREDLDVLGLSFRKDLFISTFQAYPPLPEEKKPLTRLQERLIKKLGEQAHPFYFTIPQNLPCSVTLQPGPEDTGKACGVDYEIRAFCARNMEEKMHKRNSVRLVIRKVQFAPEKPGPQPVAETTRHFLMSNRSLHLEASLDKELYYHGEAINVNVHVTNNSSKTVKRVKVSVRQYADICLFSTAQYKCPVAQIELDDLVAASSTFCKVYTLTPLLSNNREKRGLALDGKLKHEDTNLASSTIVKEGSSKEVLGILVSYRVKVKLVVSRGGDVAVELPFVLMHPKPPENISRPLSEYPQTDVPVDTNLIEFDTNFAQDDDIVFEDFARLRLKGLKDDKDDDEAYC
Protein: Aquaporin TIP1-2 (Tonoplast intrinsic protein 1-2) (MaTIP1-2) (MaTIP1;2) (P0DO54)
Organism: Musa acuminata (Banana) (Musa cavendishii)
Function: Water channel required to facilitate the transport of water from the vacuolar compartment to the cytoplasm.
Subcellular location: Vacuole membrane {ECO:0000250|UniProtKB:P26587}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MPIGSIAIGAPGEASHPDTIKASLAEFISTLIFVFAGEGSGMAFNKLTNDGSTTPAGLVAASLAHGFALFVAVSVGANISGGHVNPAVTFGAFLGGNISLIRGILYWIAQLLGSVVACLLLKLATGGLETSAFSLSSDVSVWNAVVFEIVMTFGLVYTVYATAVDPRKGDLGVIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWDNHWVYWVGPLIGAAIAALVYDGVFIGQATHEQLPPSDY
Protein: Zinc finger SWIM domain-containing protein 3 (Q96MP5)
Organism: Homo sapiens (Human)
Interaction partners:
- Zinc finger protein with KRAB and SCAN domains 4
Sequence:
MELGSCFKTYEDFKECFSAYKRENRCSFILRDCVSVRFHNLNHGTSIREDILYVQVKFVCIRTQSNRKRTREADMCPAYLLLRYNERLDRLFISELNTQHIHGDSKVASPGGDTTGKSQKTMCLQRLQPVQPTTKKDLDTAEKSLVEPSFCLDKVQVSSKPEQEGITPSDLAKIAKVMKNFLKVDEGSMASFSVGDSQHLDRLSFQSSKMTDLFIRFPENLLLHRVENTQGHILYAFLVENKERESRVVHFAVLKAETVTSVAKMLSIFTEFNSDWPKVKVVFVDPSFHYRAILQEIFPAARILLSIYHTTRLLEKKLHRSSANPSFKRLMKEALREAVFVTSEASLKNLCQMSQAVLDEDLFNFLQAHWFTCELLWYMHVRKGLLACNTYMDSLDIVTSKVSSLFREQQSLLDCILCFVDYIDFFNTKGLKNLPTPPPKLKRARPASMPLKSKKAFGICGESLTSLPAEETKPDAQQVQVQQQSQVPPSQVGMLDTLHQSGSELAYKLCHNEWEVVQNSTHLVDMAGSSVDVQLLEDSHQVSKDGCSCSCSFQQWYHLPCRHILALLHTSQQPVGEAMVCRRWQKKYQYLLGPNGELQDRGMVPNTGQPEKQGRNDMIQDLSRELANLLMQTEGPELEERYSTLRKIVDIWAGPSQPSELFQQPGDFKDVGRLPFLWGKQEEGEGFPPATAVMHY
Protein: Extent of cell elongation protein 1 [Cleaved into: ECE1-I; ECE1-II; Candidalysin ECE1-III; ECE1-IV; ECE1-V; ECE1-VI; ECE1-VII; ECE1-VIII] (Q07730)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Secreted protein cleaved by KEX2 in 8 similar peptides (ECE1-I to ECE1-VIII). Stimulates biofilm formation.
Subcellular location: Secreted {ECO:0000269|PubMed:23136884}.; SUBCELLULAR LOCATION: [Candidalysin ECE1-III]: Host cell membrane {ECO:0000269|PubMed:27027296}; Single-pass membrane protein {ECO:0000255}. Note=Candidalysin is delivered to the invasion pocket in which the hypha is tightly surrounded by the host membrane, to enable the full damage potential of during mucosal infection. {ECO:0000269|PubMed:34245079}.
Interaction partners:
- Agglutinin-like protein 3
- Hyphal wall protein 1
- Cell wall protein RBT1
- Hyphally regulated cell wall protein 1
- Hypha-specific G1 cyclin-related protein 1
- Transcriptional regulatory protein UME6
- Enhanced filamentous growth protein 1
- Agglutinin-like protein 1
- Secreted aspartic protease 5
- Induced during hyphae development protein 1
Sequence:
MKFSKIACATVFALSSQAAIIHHAPEFNMKRDVAPAAPAAPADQAPTVPAPQEFNTAITKRSIIGIIMGILGNIPQVIQIIMSIVKAFKGNKREDIDSVVAGIIADMPFVVRAVDTAMTSVASTKRDGANDDVANAVVRLPEIVARVATGVQQSIENAKRDGVPDVGLNLVANAPRLISNVFDGVSETVQQAKRDGLEDFLDELLQRLPQLITRSAESALKDSQPVKRDAGSVALSNLIKKSIETVGIENAAQIVSERDISSLIEEYFGKA
Protein: Sodium-dependent nutrient amino acid transporter 1 (B4GVM9)
Organism: Drosophila persimilis (Fruit fly)
Function: Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MELKGVHQQNGTSNGTGAVGAEGESAPPTAPATAEAAASLETTTEKVDAEQQKPERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFATICIITYYSSLLALTLYYLFVSFQSVLPWSYCWEEWMNCVDSRPQEDTDALLLSSSNVTNVTALTDTVKLQSSSELYFLNVVIKEKMDISDGIGDPDWKLTLALFVSWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFILLVRAVTLEGARDGIIFFLEPQWGELLNPTVWKNAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTILCDQFKSWKYWKVALATSICGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWIYGMQNFCDDVEFMCNRRVSLYWRVCWSFFTPVMMIVIFIYSMVTIEPITYSEQFFPEAGNVAGWLLFGIGAAQFPLWWMWYISQHREGSLGQSFVASLRPSDKWGPANPETKRQWVIFKNEKAAQRATKKQSSKLGAFWQKLGHFCGSNT
Protein: Suppressor of mec-8 and unc-52 protein homolog 1 (AtSMU-1) (RNA splicing protein SMU1) (WD40 repeat-containing protein SMU1) (Q8W117)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxiliary spliceosomal protein involved in splicing of specific pre-mRNAs that affect multiple aspects of development. Required for proper accumulation of SMU2.
Subcellular location: Nucleus {ECO:0000269|PubMed:19734266}.
Interaction partners:
- Suppressor of mec-8 and unc-52 protein homolog 2
- Pre-mRNA-processing-splicing factor 8A
- Protein STABILIZED1
- Microfibrillar-associated protein-like protein
- Microfibril-associated protein-like
- Pre-mRNA-splicing factor 38
- Sm protein F
- Zinc finger protein ZOP1
- Nuclear protein-like
- Probable small nuclear ribonucleoprotein F
Sequence:
MALEIEARDVIKIMLQFCKENSLNQTFQTLQSECQVSLNTVDSVETFISDINSGRWDSVLPQVSQLKLPRNKLEDLYEQIVLEMIELRELDTARAILRQTQVMGVMKQEQAERYLRMEHLLVRSYFDPHEAYGDSTKERKRAQIAQAVAAEVTVVPPSRLMALIGQALKWQQHQGLLPPGTQFDLFRGTAAMKQDVEDTHPNVLTHTIKFGKKSHAECARFSPDGQFLASSSVDGFIEVWDYISGKLKKDLQYQADESFMMHDDPVLCIDFSRDSEMLASGSQDGKIKIWRIRTGVCIRRFDAHSQGVTSLSFSRDGSQLLSTSFDQTARIHGLKSGKLLKEFRGHTSYVNHAIFTSDGSRIITASSDCTVKVWDSKTTDCLQTFKPPPPLRGTDASVNSIHLFPKNTEHIVVCNKTSSIYIMTLQGQVVKSFSSGNREGGDFVAACVSTKGDWIYCIGEDKKLYCFNYQSGGLEHFMMVHEKDVIGITHHPHRNLLATYSEDCTMKLWKP
Protein: Uncharacterized protein (A0A1D8PH05)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Arp9p
- Snf5p
- Swi1p
- DNA-directed RNA polymerase subunit
- TATA-binding protein-associated factor
- Uncharacterized protein
- DNA-directed RNA polymerase subunit
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 14
Sequence:
MNKKTLQAQAELARAQQAQAQAQMQAQRAAAAGQLAPGGNGGGIPPPNGQSQHSAKEETLGVQLHDEADLISFRNDALFRYITNHEYIENVTSKLIHTSKIIPPSLYPMIPKPNTSGDYENLKPEDVYFGDLSAMKYIEKKLITKLEQMEKNLDPNYSKYLLNDERFQYHREKTKKLAELQENVTDKESLNTLELELEQILNDYKTRFNKNYKETPSIYQYSISIDKIDPSVEVNSAPENYNPKSINSFINIGGDTNSSQNNINGNMPSQNNNGAVSEMGNFNNIDNGVDDDALGGFQFSNNIDTSKFNGINGMAINQFGNNFEVPMNNKPDAININNNNKILINKSDSDGNIENNNSNSRSNTPSNINTNNINSQGPSENISSINHNTSNSIPNYSTNGSDNDNIEQDDINIDDEGDNIINNDDDNNNIASPNRIDNDENDNNNDSNGLDMNQLFEDNAHADLDHSEMVNDDIGDLYNFETGGGGDDDDNGLMDGLEFEQDFLN
Protein: Probable protein phosphatase 2C 54 (AtPP2C54) (EC 3.1.3.16) (Q9T010)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative protein phosphatase 2C 53
- Putative protein phosphatase 2C-like protein 45
- Putative protein phosphatase 2C-like protein 44
- Probable protein phosphatase 2C 71
- Probable protein phosphatase 2C 36
- Probable protein phosphatase 2C 2
- Probable protein phosphatase 2C 52
- 60S ribosomal protein L36
- Probable protein phosphatase 2C 80
- Probable protein phosphatase 2C 30
Sequence:
MKTDTTLPIIAEDGDCGDSKRVRVADSGYTVGGQDRPVKLPKIENNGDVGTSEGTHVLVDALMAEVAIKDKDGKTNAGHGVVSVMGRQRAMTTAVSTVVDEIPSYDIFGIFDGLRLAKFFEDRLRRLVKEEVKACHGRGVAADWNKVMKSCFSEAVGTVGTTTSAVVTIVGKEEVIVLCRGGARVVLYSHDGVALPLCHIHHHKDGVEQILKIHKRKKIDDFIVLACDGLWDVVSDDDTYQLVKRCLYGKLPPDGCISESSSTKAAVILAELAIARGSKENINVIVIDLKSSTVS
Protein: Antimicrobial peptide 2 (ToAMP2) (B3EWQ2)
Organism: Taraxacum officinale (Common dandelion) (Leontodon taraxacum)
Function: Antimicrobial peptide. Active against fungal species B.cinerea (IC(50)=5.2 uM), A.niger (IC(50)=2.6 uM) and B.sorokinina (IC(50)=5.2 uM) but not against F.oxysporum, F.graminearum and P.debaryanum at concentrations below 10 uM. Inhibits growth of P.infestans at concentration between 1.3 uM and 5.2 uM. Active against bacterial species P.syringae, B.subtilis, X.campestris and C.michiganense.
Interaction partners:
Sequence:
GGKCTVDWGGQGGGRRLPSPLFCCYKPTRICYLNQETCETETCP
Protein: Large ribosomal subunit protein mL40 (54S ribosomal protein L28, mitochondrial) (YmL28) (P36527)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein mL38
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL3m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein bL36m
Sequence:
MLAQTFKKPHRAVLEQVSGTTVFIRNKRTKSKSSLSPLAQRVVTQLSVMSASRKQPKLLKLAREDLIKHQTIEKCWSIYQQQQRERRNLQLELQYKSIERSMNLLQELSPRLFEAANASEKGKRFPMEMKVPTDFPPNTLWHYNFRK
Protein: UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase) (P9WJL5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00639}.
Interaction partners:
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- UDP-N-acetylmuramate--L-alanine ligase
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
- Phospho-N-acetylmuramoyl-pentapeptide-transferase
- Glutamate racemase
- Probable peptidoglycan glycosyltransferase FtsW
- Cell division protein FtsQ
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase
- D-alanine--D-alanine ligase
Sequence:
MSGLPRSVPDVLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAARELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR
Protein: R3D1 (Q27IS6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
FAPRRHYNNLVGLGNGNAVSGSPVKGAPLGQRHVKLKKEKISAQVAQLSQPGQLQLSDVGDPALAGGSGLQGGVGLMGVILPSDEALKFVSETDANGLAMKTPVSILQELLSRRGITPGYELVQIEGAIHEPTFRFRVSFKDKDTPFTAMGAGRSKKEAKHAAARALIDKLIGAQLPESPSSSAGPSVTGLTVAGSGGDGNANATGGGDASDKTVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTLTTQHSNKVSQFHKTLKNATGKKLLKLQKTCLKNNKIDYIKLLGEIATENQFEVTYVDIEEKTFSGQFQCLVQLSTLPVGVCHGS
Protein: Protein STB3 (SIN3-binding protein 3) (Q12427)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transcriptional regulatory protein DOT6
- Transcriptional regulatory protein TOD6
- Transcription factor SFP1
- Serine/threonine-protein kinase SCH9
- Pre-rRNA-processing protein FHL1
- Histone deacetylase RPD3
- Protein IFH1
Sequence:
MSENQKEVSPPQAISVKSEASSSIFSKPISTSSPAGLAAAQRVTPGKLSTLLLEMGPLAIRHITQTLCLDIPCFKDLSSSKQRRLIMSAMESGDKEKSVVFEKIGWGQWSAKRVDPANFDKELEATNFANAKVKDLISQESQRRKSNNSNSNSGGKVEMPMKVEHNITNIDGATTPPTAVASTTIPVNIKRSKSPLAAANVVYIDENALASEDEDEEFDEDDHHLHYQNKSRNSSNNFGKSSNGDPYSFGRRRSQVVFADSTPENIEHEIIAQKIRPLLRNRRRSSIKPHTPFISKLNTHQDSSYLSPNTTSTTTPSNNNSNSNQAKIDLEKLTATSEPTSRRASRLSVSKESSIRSTLFPNKNYLIVTTNPNSKATSVSTSPKLEEQMNVSSNPIVLSDKEKHRVASQHLNGESSPQLVPHSHHQPHSDTDEEDWESIGAASLRNNSLAPNIDSVASSTNGVVSPKPTNPSFTNSQNGDIEPPLQHDQQKHEQQPRNGEDNSAAFLLMSLKS