wanglab/gogpt-training-data huggingface dataset:
Protein: LP18470p (Protein tyrosine phosphatase Meg2, isoform B (EC 3.1.3.-, EC 3.1.3.48)) (Q9W324)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVHLYQRRRNREQAVKQFIDLCNNLGANCSTTTATSPSTSSSSASSTQNLIAVVPPQLQQLQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRHISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPARTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANNSSSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQTVDLAGFDEREPDSE
Protein: Germ cell-specific gene 1 protein (Q2KHT4)
Organism: Homo sapiens (Human)
Function: May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with PAPOLB in the endoplasmic reticulum. {ECO:0000250}.
Interaction partners:
Sequence:
MAKMELSKAFSGQRTLLSAILSMLSLSFSTTSLLSNYWFVGTQKVPKPLCEKGLAAKCFDMPVSLDGDTNTSTQEVVQYNWETGDDRFSFRSFRSGMWLSCEETVEEPALLHPQSWKQFRALRSSGTAAAKGERCRSFIELTPPAKREILWLSLGTQITYIGLQFISFLLLLTDLLLTGNPACGLKLSAFAAVSSVLSGLLGMVAHMMYSQVFQATVNLGPEDWRPHVWNYGWAFYMAWLSFTCCMASAVTTFNTYTRMVLEFKCKHSKSFKENPNCLPHHHQCFPRRLSSAAPTVGPLTSYHQYHNQPIHSVSEGVDFYSELRNKGFQRGASQELKEAVRSSVEEEQC
Protein: Cytochrome P450 26A1 (CYP26A1) (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome) (O43174)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers. May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:9716180}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:9716180}; Peripheral membrane protein.
Interaction partners:
- Retinal dehydrogenase 2
- Retinol dehydrogenase 10
- Retinaldehyde dehydrogenase 3
- Short-chain dehydrogenase/reductase 3
- Lecithin retinol acyltransferase
- Aldehyde dehydrogenase 1A1
- Alcohol dehydrogenase class-3
- Retinol dehydrogenase 11
- Alcohol dehydrogenase 6
- Retinol dehydrogenase 16
Sequence:
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
Protein: CST complex subunit CTC1 (Protein CONSERVED TELOMERE MAINTENANCE COMPONENT 1) (AtCTC1) (D0EL35)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Associates with enzymatically active telomerase.
Subcellular location: Nucleus {ECO:0000269|PubMed:19854131}. Chromosome, telomere {ECO:0000269|PubMed:19854131}.
Interaction partners:
- CST complex subunit TEN1
- CST complex subunit STN1
- Protection of telomeres protein 1a
- Protection of telomeres protein 1b
- Protection of telomeres protein 1c
- Telomerase reverse transcriptase
- Telomere repeat-binding factor 1
- ATP-dependent DNA helicase 2 subunit KU70
- Telomere repeat-binding protein 1
- Cysteine/Histidine-rich C1 domain family protein
Sequence:
MENTTILTVKDLVNEGIAVTGASSLFSSAASHSSSESTSTNPKSHPGAVDSDFSRKFLTPLNYPTVIFGTVALPSETLKCPNRYCFRFTDGDLTICCDILGFEFRAIGSKICVLSWNFLPMNHSGGFLEIINWKFVDSGSLLSRCSGISSFPLIPSLYSSQNGDRKSRYSVCGVLESISPVSVVPCMDGVSSDSVNLPGFLVHVMACECKVYSRDAIDCGHAFERSVFVYFCGLEAASWHPVVMKLVGRNVALSGLKRKLVYVRGDSLLVFVTTENSVLHPPWLSKKGTVSKTVVDRRGNCGSYRGYVRGLYLKGKLVEMDEDVWLLLTDQILNRSHSIRTGSLIFIRNVHFVNTKFPWGEVLILGACFKTSITVEFFSPFETSCLVDSCRQTSLSLYVESLSFPARLWTLLVRISFEKFNRMPSDKEILRSCQKDELTKMYAESRIPPSMFQPRGGIFTEFCMHESCGCNSEARDCNLKLVMPISSFVHHVKVMLNELLSQIKKDFSASDCLSHSSSTWKRYNNTNPKTLRSEDTGVILLGRLKISSSGRLQLHDRTSSIDVLTPDLLSDRNASRICEVPDYYLIIEGIPESMLHMPFLKNPFRCSSVLNPTPLAIKNTLTVPFSLSLGTASCKHLLKHHPFDWRHDFNEFKEGFFHLFRVTHKFPILKNGHPGMPDCTSVFIEALVLPWDLICTVTEEEAAAPNFEEHDTSQEIRPHKRCKTNNGLQSQSFLSVPHEISCQMTIRCASSHCLVATATLSNLTENKSGKMHSAMRVLLEFIPECSNYYGLQIGGCYLMKHGSDDSFCVGRSGISNNDKINFRPETRLWSLEFSFDEVLTHDGSMDVHPLVSSQPSFAVEQQNVSSRQPCSDVSLLLPYDAKGLFSVFLNDLEGLNKPLAAGKDNNNISCCTQSETIMHAEPSRLLPSNSLFPEGNLATFRGDVVAVDAVTSSVVDVSSSYCINVLVNHQMVKIFGPLRRHSYLTGFGFGTNATFYRILGTGEQNSFVLTSASFIKINSRKALDSPPLEKPTHGAALCLPKITPQEFVPCILAGPACNSFSGNEDNQQIKFACKVLSVYLLVLQTRSDDPSENECRNNIDIPLAGFVVDDGSSTYLCWTSGERAFTILRLHEELPEETIDVVQWTRRYSNWGTTAYHLDQIVRVHKRIVMKCNGSQIDVLFQDITIAVTSDQLLTKSEDKFLKWLILNAISGPIWEVAASSMDMKMIEHLEREQCVEMETSRYNLQSVWGNEVCQVDPLVRAWSLLQGLLNS
Protein: UPF0659 protein YMR090W (Q04304)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Bud site selection protein 22
- Cytochrome c1, heme protein, mitochondrial
- RNA polymerase I-specific transcription initiation factor RRN11
- Acyl carrier protein, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Uncharacterized protein YPL245W
- FAS1 domain-containing protein YDR262W
- Cytochrome b-c1 complex subunit 8, mitochondrial
Sequence:
MSPMKVAVVGASGKVGRLLINQLKANDSFSTPLAIVRTQDQVNYFKNEVGVDASLTDIENASVSEITDAIKAYDAVVFSAGAGGKGMERIFTVDLDGCIKVVEACEKAGIKRFVVVSALKAEDRDFWYNIKGLREYYIAKRSADREVRNSNLDYTILQPGSLELNKGTGLLQPLDKLEEKASVNYSINREDVASFIVESLLHPNATVKKTISLVNGNEPMEKFIQSL
Protein: Lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.3.9) (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase) (Ganglioside GM3 synthase) (ST3Gal V) (Sialyltransferase 9) (F1RCA6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Interaction partners:
- Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
- Beta-1,4 N-acetylgalactosaminyltransferase.
- Beta-1,4 N-acetylgalactosaminyltransferase
- Lactosylceramide alpha-2,3-sialyltransferase
- Beta-hexosaminidase
- Beta-hexosaminidase.
- UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6.
- Beta-galactosidase.
- Beta-galactosidase-1-like protein precursor
- Reticulon 4 receptor-like 1b.
Sequence:
MRRVMKQSSCYFSKRTMILLLSLALMSLAFLKLPSFHTELKPVEVPVDNKFRKRVHSHVREILDKECRPSFARQRMVTEHHGSTPTIDPFLNKNMKLDEQIFQYPPPFGFLDMKNKLEEILNLLPVSSEQRLGERDCRRCVVVGNGGILKGLGLGHLLNRFDIIIRLNSGPLQDFSADVGNRTTIRMSYPESCPKVWEDTDPDLKYVAVIFKSVDFHWLRAMISRTPVSLWDRLFFWQNVPMSVPVKTSQFHLLNPQIIREMALDLLNYPEPKKRLWSWDQNIPTLGLTALNLATYICDEVSLAGFGYNLSQKEAPLHYYDSVPMTTILKEAMHNVQKETVFLKRLVASGSITDLTGGIHCSFC
Protein: Synaptopodin 2 variant (A7UMX5)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MIQSAAPSIPRVEVILDCSDREKEAPKSLAERGCVDSQVEGGQSEAPPSLPSFAISSEGTEQGEDNQHSEKDHRPLKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTAAPNPNSKGVLMFKKRRQRARKYTLVSYGTGELERDEDEGEEGEVEEGDKENTFEVSLLATSESEIDEDFFSDIDNDKKIVTFDWDSGLLEVEKKTKSGDEMQTLPETTGKGALMFARRRQRMDQITAEQEEMKARTAHAEEQREVTVSENFQKVSSSAYQTKEEEMLRQQPCISKSYADVSQNDGKIVQQNGFGVAPDTSLSFQSSEAQKAASLNRTAKPFPFGVQNRAAAPFSPTRNVTSPLSDLPAPPPYCSISPPPEALYRPLSAPAASKAAPILWSHTEPTERIASRDERIAVPAKRTGILQEAKRRSTSKPMFSFKEAPKVSPNPALLSLVHNAEGKKGSGAGFESGPEEDYLSLGAEACNFMQSQASKQKAPPPTAPKPSLKVSPAAGTPVSPVWSPAVASNKAPSFPAPASPQAAYPAPLKSPQYPHSPSANPPNTLNLSGPFKGPQATLASPNHPAKTPTTPSAGETKPFEMPPEMRGKGAQLFARRHSRMEKYVVDSETVQANMARASSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPPAATKPFPKSTAATKNTKRKPKKGLNALDIMKHQPYQLDASLFTFQPPSNKESLGIKQIPKLPTSKQATSLRLPGSASPTNVRASSVYSVPAYSSQPSFQSNASTPVNESYTPTGYSAFSKPESTTSSLFTAPRPKFSAKKAGVIAQERSSGRSLSLPGKPSFISRATSPTSPLIFQPAPDYFSKPDTAADKPGKRLTPWEAAAKSPLGLVDEAFRPQNMQESIAANVVSAAHRKTLPEPPDEWKQKVSYEPPGPSASLALLGGKQPGVTSARKSSLSVSNATTQAGSQQQYAYCSQRSQTDPDIMSMDSRSDYGLSTADSNYNPQPRGWRRPT
Protein: tRNA-specific adenosine deaminase 2 (EC 3.5.4.33) (Deaminase domain-containing protein 1) (tRNA-specific adenosine-34 deaminase subunit ADAT2) (Q7Z6V5)
Organism: Homo sapiens (Human)
Function: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.
Interaction partners:
- Probable inactive tRNA-specific adenosine deaminase-like protein 3
- tRNA-specific adenosine deaminase 1
- Thymidylate synthase
- Small ribosomal subunit protein uS2
- Uracil phosphoribosyltransferase homolog
- General transcription factor IIH subunit 1
- 5'-nucleotidase
- Thymidine kinase, cytosolic
- Histone acetyltransferase p300
- Progonadoliberin-2
Sequence:
MEAKAAPKPAASGACSVSAEETEKWMEEAMHMAKEALENTEVPVGCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQVLDWCRQSGKSPSEVFEHTVLYVTVEPCIMCAAALRLMKIPLVVYGCQNERFGGCGSVLNIASADLPNTGRPFQCIPGYRAEEAVEMLKTFYKQENPNAPKSKVRKKECQKS
Protein: Transcription factor sma-9 (Q7JM44)
Organism: Caenorhabditis elegans
Function: Transcription factor, probably acting as a transcriptional activator and repressor, involved in the TGF-beta-like dbl-1 signaling pathway. Plays a role in regulation of body size, and patterning of male-specific genital sensilla (simple sense organs), known as rays, and mating-associated structures, spicules. Required for the dorsoventral patterning of the postembryonic mesodermal lineage (M lineage), acting by antagonizing the TGF-beta-like dbl-1 signaling pathway, in part by repressing expression of transcription factor unc-130. Involved in egg-laying, perhaps via modulation of cholinergic neurotransmission. May play a role in modulating lifespan and in responses to proteotoxic stress.
Subcellular location: Nucleus {ECO:0000269|PubMed:14627718}.
Interaction partners:
Sequence:
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
Protein: Ribulose bisphosphate carboxylase large chain (RuBisCO large subunit) (EC 4.1.1.39) (P00880)
Organism: Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Function: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
Subcellular location: Carboxysome {ECO:0000255|HAMAP-Rule:MF_01338}. Note=In the carboxysome RuBisCO is organized into a paracrystalline array (By similarity). This cyanobacterium makes beta-type carboxysomes (Probable). {ECO:0000250|UniProtKB:Q31NB3, ECO:0000305}.
Interaction partners:
Sequence:
MPKTQSAAGYKAGVKDYKLTYYTPDYTPKDTDLLAAFRFSPQPGVPADEAGAAIAAESSTGTWTTVWTDLLTDMDRYKGKCYHIEPVQGEENSYFAFIAYPLDLFEEGSVTNILTSIVGNVFGFKAIRSLRLEDIRFPVALVKTFQGPPHGIQVERDLLNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSQPFQRWRDRFLFVADAIHKSQAETGEIKGHYLNVTAPTCEEMMKRAEFAKELGMPIIMHDFLTAGFTANTTLAKWCRDNGVLLHIHRAMHAVIDRQRNHGIHFRVLAKCLRLSGGDHLHSGTVVGKLEGDKASTLGFVDLMREDHIEADRSRGVFFTQDWASMPGVLPVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRDLYREGGDILREAGKWSPELAAALDLWKEIKFEFETMDKL
Protein: Magnetite biomineralization protein Mms6 (Magnetosome protein Mms6) (Q2W8R5)
Organism: Paramagnetospirillum magneticum (strain ATCC 700264 / AMB-1) (Magnetospirillum magneticum)
Function: Promotes the formation of magnetite in Fe(2+)-rich conditions, when magnetite is not readily formed. Binds Fe(3+) and Fe(2+) (Probable). May play a role in nucleation of magnetite crystal formation (Probable). May help control production of crystals with a specific morphology (Probable). Greatly improves the formation of magnetosome-like magnetite crystals in vitro. Isolated short protein, probably residues 75-133, binds up to 18 Fe(3+) per monomer and self-assembles into micelles about 21-26 nm in diameter; the C-terminal 21 residues also self-assemble.
Subcellular location: Magnetosome membrane {ECO:0000269|PubMed:12496282, ECO:0000269|PubMed:16303747, ECO:0000269|PubMed:27759096, ECO:0000269|PubMed:28955887}; Single-pass membrane protein {ECO:0000255}. Note=Tightly associated with magnetite crystals (PubMed:12496282). Tagged protein forms straight lines with a punctate pattern extending along most of the cell associated with its inner curvature, in the correct position to be associated with magnetosomes. Under aerobic conditions, when magnetites cannot form, or in the absence of iron, the protein is dispersed in the cell, probably in the inner membrane; as magnetosomes form tagged Mms6 localizes in a line that corresponds to the position of magnetite crystals (PubMed:27481925). Short protein seems to localize specifically to magnetosomes which have magnetite crystals (Probable). {ECO:0000269|PubMed:12496282, ECO:0000269|PubMed:27481925, ECO:0000305|PubMed:27481925}.
Interaction partners:
- Magnetosome protein MmsF
- Magnetosome protein MamC
- Magnetosome protein MamD
- Magnetosome protein MamF
Sequence:
MGEMEREGAAAKAGAAKTGAAKTGTVAKTGIAAKTGVATAVAAPAAPANVAAAQGAGTKVALGAGKAAAGAKVVGGTIWTGKGLGLGLGLGLGAWGPIILGVVGAGAVYAYMKSRDIESAQSDEEVELRDALA
Protein: DESERT (Q9NHX5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSYRSYTPWKTSLGSSYKPGSSTYGTSGDSTSRYTSLATPSSYRPSFSGGTYRLKRDPPPPVTTTPVSSYVSRYAKTEPKDAAPSERSSPVKRYTGNTTSSLGKYGRSRDPSPVALEHTNRNKSRDPSPVIDSARSKLGSTYRGGNTPTTSSSSSSATRNAYSSRYGAGSRISGNGSALSYLTTSDFHARTASRAKASREREREKEKEKEKEQEIEEKPSETSNGIDKSPAKQQVEKPENDEEPNETFITISVVTRATSPTLPGSTTVQRTRRIDPAKTIEKTIQRSSKRRETTDQEIQSDRLDDSTRYLRYSAGSSISSTYSPHRDRISSLRYSASPLNSSGSAKSSSVGEGKQIQPIPETVSPARTNGSVSSAKSSEALSPPRTNGNVSSGKSSEALSLPRSNGCSSKSTEAVSPPRTNGSLSSSKSTKSKLSPPKAIRLNSRQSSVENLVNKPPAPPSKADSPTKTCSSSSGSSAVKWPNKDFRKSSLNVGPTDRPRKSRTPSSGGESEDLPNGSSLERSPSAGSDGSLASGSSSKKSSKLSNGKVPGSLKPKSHKSCSETTTGNSSSATASASDSEQRVKSVKKQAKKKTTTKEGGAGKVANANKTNSTTESPPAVVDVVPATQTRLKKLSAVSNFFASRQQDANNEPIFLESSESSGEPEAHSLPVISAISGTSKISKISGISLTTDLRTNEPRTTPSSEAKQSPQTNSPSSSTRCPRETTTETGTRLPSSTTSTTQESSLTTTASLTTSEQDDPSWWQDTSLQINTASALDQNNRGEMPSYRLRHIDSGEEQAWWLRQDENGDDDDTLAEETLNTLDDDLQEPSKSTWWSQDDQDSSSQVKLMPRSRITPEKDAWWLQDEDEAAKSPIENGDLNNNNNSEPHVEVTLRLPSNGSQRSSKSSASKNGSNPKSGGANPWWLSGPARKMFNVQRVESGERAWWQEEAEEPPQEEKESEPPPVKPPTPPPRIIKHWESGERAWWLQDETESNQLPVQASSDDEEQPVLVVINQQESRDEVDLRLAPPTLESQELSNSFNFDAHSERPPPLGQCASPVRCPSPYDNIPRSQLQEPPPPPTTTLTSLQPRFSPQTRRAGEKLFISRHQNIDELLGGACRPLSPLFYGNSNPAESELTPLAGKNMFLLEEVTPDQVRIHDSTAQLPVIQRMQTPQLEG
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (B7Z4L4)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU361143}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU361143}.
Interaction partners:
Sequence:
MRVKLASRNVESYTKLGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKALTSEIALLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLISGKRQELVTKIDHILDAL
Protein: Protein unc-13 homolog C (Munc13-3) (Q62770)
Organism: Rattus norvegicus (Rat)
Function: May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:9895278}. Membrane {ECO:0000305|PubMed:9895278}; Peripheral membrane protein {ECO:0000305|PubMed:9895278}. Presynaptic cell membrane {ECO:0000305|PubMed:9895278}; Peripheral membrane protein {ECO:0000305|PubMed:9895278}. Note=Localized to presynaptic structures. {ECO:0000305}.
Interaction partners:
- Protein unc-13 homolog B
- Regulating synaptic membrane exocytosis protein 2
Sequence:
MVASLFKSLILAYIHKLCKGMFTKKLGNTTKKKENRQQNKDQDFPTAGHTKPPKLSNALKSTVKKIAKCSSTRNFSVEDEEGHKDFSLSPTFSYRVAIANGLQTAVTNSDEDLLQELSSIESSYSESFNELRSSTENQVQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHTLKLGALRKLRKWKKSQECVSSDSELSTVKKTWGIRSKSLDRTARNPKTNVLEPGFSSSGCISQTHDVMEMIFKELQGISQIETELSELRGHVNALKYSIDEISSSVEVVQSEIEQLRTGFVQARRETRDIHDYIKHLGHMGSKVSLRFLNVPEERHEYVESVVYQILVDKMGFSDVPNAIKIEFAQRIGQQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIAISTDILTYDIRERKEKGVLPSSQTYESMDMKLSTPEPKAKKNAWLSPNDSDRELESDLSRSSYADSPAKGSSSKSSSKSHSARSKNKAANSRTSQKSDYNKRPSKPPASEKPTPHYVEATPLWHSQSDFFTPKLSRSESDFSKLCQSYSEDFSESQFFCRTNGSSLLSSSDRELWQRKQEGMTALYHSPQDQGLDGNIPTVPGQGEIENTETVDSGMSNSVVCASGDRSNYSGSQLSLHEDLSPWKEWNQAGHGTDGLDSSTQEPFDYDTNSLSDQQLDMSSKDLDDLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYDSYQKTNSNDLYPNQSHPSMMYRSQSELQSDDSEAAQPKSWHSRLSIDLSDKTFKFPKFGSTLQRAKSALEVVWNKSTQSLSGCEDSGSSLMGRFRTLSQSTANESSTTLDSDIYTEPYYYKAEEEEDYCEPVADSETDYVEVMEQVLAKLENRTSVTEVDEHIKEYDHPSYETPYETPQDEGYDGQADDIISEGELETLNEPAVEMELVEDESQNLPVEPPEVMKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQVFGGAGRGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHVFRKTLQALIYPISSTTPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIRERNRPEVFEVIQEMFQISKEDFVQYTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGSVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGVESIYQAMTHFSCLSSKYMCPGVPAVMSALLANINAFYAHTTVSTNVQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPASNSERLQDLKSTVDLLTSITFFRMKVLELQSPPKASAVVKDCVRACLDSTYKYIFDNCHELYSQLIDPSKKQDVPREEQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWSLFALDMKYALEEHEKQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSDHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLVQYAAIVSSDFSSYCDKETVPCILMNNIQQLRVQLEKMFESMGGKELDPEASTILKELQIKLNGVLDALSVTYGESFQLVIEECIKQMGAELNQMRANGNSAANKNNAAMDAEIVLRPLMDFLDKILSLSAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKELGQLSKLKEHMIRDDAKGLTPRQCAIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLHSLRYALSLYTQTTDALIKKFIETQGSQSRSSKDAVGQISVHVDVTTTPGTGEHKVTVKVIAINDLNWQTTTMFRPFVEVCMLGPSLGDKKRKQGTKTKSNTWSPKYNETFQFILGNENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNLSMDETGLTILRILSQRTSDDVAKEFVRLKSETRSIDESA
Protein: Formyl peptide receptor-related sequence 6 (Q3SXG2)
Organism: Mus musculus (Mouse)
Function: May have an olfactory function associated with the identification of pathogens or of pathogenic states.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Heme-binding protein 1
Sequence:
MEANFSIPQNGSEVVFYDSTTSRVICIFLVVVLSITFLLGVIGNGLVIYVAGFRMTHTVTTICYLNLALSDFSYMASLPFQITSIVMNGEWLFGWFLCKFVHMIINVNLFLSIFLITFIAMDRCICVLHPVWAQNHRTVNVATKVIFGAWILVLMLIFPHCIFVTTVKDESGKVHCICNFESWAATPEEQVKVSMTVSLISVTISFIIGFSIPMIFIVICYGLMAAKIGRRGFVNSSRPLRVLTAVAISFFVCWFPFQLIFLLGNIGNKETQNNIDTWVNTASTLASFNSCLNPILYVFLGQQFRERLIYSLSASLERALREDSALNSDKTRNLSSQRL
Protein: TMP (Tape measure protein) (Q9G097)
Organism: Lactococcus phage TP901-1
Interaction partners:
Sequence:
MESFSVQAYLKATDNNFVSTFKDAAKQVQNFEKNTNSTMSTVGKVATSTGKTLTKAVTVPIIGIGVAAAKIGGDFESQMSRVKAISGATGSSFEELRQQAIDLGAKTAFSAKESASGMENLASAGFNAKEIMEAMPGLLDLAAVSGGDVALASENAATALRGFNLDASQSGHVANVFAKAAADTNAEVGDMGEAMKYIAPVANSMGLSIEEVSAAIGIMSDAGIKGSQAGTSLRGALSRLADPTDAMQAKMDELGLSFYDSEGKMKPLKDQIGMLKDAFKGLTPEQQQNALVTLYGQESLSGMMALIDKGPDKLGKLTESLKNSDGAADKMAKTMQDNMNSSLEQMMGAFESAAIVVQKILAPAVRKVADSISGLVDKFVSAPEPVQKMIVTIGLIVAAIGPLLVIFGQAVVTLQRVKVGFLALRSGLALIGGSFTAISLPVLGIIAAIAAVIAIGILVYKNWDKISKFGKEVWANVKKFASDAAEVIKEKWGDITQWFSDTWNNIKNGAKGLWDGTVQGAKNAVDSVKNAWNGIKEWFTNLWKGTTSGLSSAWDSVTTTLAPFVETIKTIFQPILDFFSGLWGQVQTIFGSAWEIIKTVVMGPVLLLIDLITGDFNQFKKDFAMLWQTLFTNIQTLVTTYVQIVVGFFTAWGQTVSNIWTTVVNTIQSLWGAFTTWVINMAKSIVDGIVNGWNSFKQGTVDLWNATVQWVKDTWASFKQWVVDSANAIVNGVKQGWENLKQGTIDLWNGMINGLKGIWDGLKQSVRNLIDNVKTTFNNLKNINLLDIGKAIIDGLVKGLKKKWEDGMKFISGIGDWIRKHKGPIRKDRKLLIPAGKAIMTGLNSGLTGGFRNVQSNVSGMGDMIANAINSDYSVDIGANVAAANRSISSQVSHDVNLNQGKQPASFTVKLGNQIFKAFVDDISNAQGQAINLNMGF
Protein: beta-ketoacyl-[acyl-carrier-protein] synthase I (EC 2.3.1.41) (Q586W9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Acyl carrier protein
- 3-oxoacyl-
- Fatty acid elongase 1
- 3-methylcrotonyl-CoA carboxylase, putative
- lipoyl
Sequence:
MAFGTFPPQVRRRVVVTGLGAVTPLGVGAQSTWSALCEGKSATRALREAPFFFPSSIDSDRRLTTEEKGKRREELLAAMPCQVAAPVIGELVSTTDLPNFAPTSRETRATRFALHAVREALIHAKLIGTDVFCALPSGAVAHPNEAASDNSKRSSAPERRIASSCSAERIGVNLGVGMPSLVDVCDAAYNLFADPAQIRYNSISPLFVPKILGNMLTGLVAMTYNVHGPVGSSVGACATGGHCIGESASWIQQGRADVVICGSAEACITPVAIAGFSRMRALCTKYNNRPQEASRPFDKDRAGFIMGEGAGVLVLESLEHARERGAHIIAELRGFGTSSDAHDVAAPRPDGYGAKLCLRSALRDGGDVPAACVAYVNAHATGTIGDDLELHAIEAVLNGTDGSDNKSAIIRNSPLLVSSVKGGIGHLLGAAGSVEAAVAVMALHEQRAPPNVNLHVPSFPASGAIQLVQGTTACAFKGEAVLSTSFGFGGMSTALLFTQF