wanglab/gogpt-training-data huggingface dataset:
Protein: DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153) (P35638)
Organism: Homo sapiens (Human)
Function: Multifunctional transcription factor in endoplasmic reticulum (ER) stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (By similarity). Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes (By similarity). Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (By similarity). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (By similarity). Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29083303}. Nucleus {ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:33384352}. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. {ECO:0000269|PubMed:29083303}.
Interaction partners:
- Cyclic AMP-dependent transcription factor ATF-4
- CCAAT/enhancer-binding protein beta
- Cyclic AMP-dependent transcription factor ATF-6 alpha
- Cyclic AMP-dependent transcription factor ATF-3
- X-box-binding protein 1
- Apoptosis regulator Bcl-2
- Nuclear factor erythroid 2-related factor 2
- Bcl-2-like protein 11
- Eukaryotic translation initiation factor 2 subunit 1
- Mitogen-activated protein kinase 14
Sequence:
MAAESLPFSFGTLSSWELEAWYEDLQEVLSSDENGGTYVSPPGNEEEESKIFTTLDPASLAWLTEEEPEPAEVTSTSQSPHSPDSSQSSLAQEEEEEDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRALIDRMVNLHQA
Protein: Histone deacetylase 1 (EC 3.5.1.98) (O17695)
Organism: Caenorhabditis elegans
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. Required during mitochondrial stress for the activation of genes involved in the mitochondrial unfolded protein response (mtUPR), in concert with homeobox protein dve-1. Promotes normal hermaphrodite (XX) development, in concert with zinc finger protein tra-4 and nasp-1, perhaps as components of a complex. Plays a role in the regulation of longevity and mtUPR-associated innate immunity. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide genes in response to fungal infection.
Subcellular location: Nucleus {ECO:0000269|PubMed:32934238}. Cytoplasm. Chromosome {ECO:0000269|PubMed:32934238}. Note=Except in the germ line where it is also cytoplasmic.
Interaction partners:
- Probable histone-binding protein lin-53
- DIOX_N domain-containing protein
- Protein let-418
- Suppressor of hairless protein homolog
- Putative histone deacetylase 2
- Histone deacetylase
- C-terminal-binding protein 1
- Probable histone-binding protein rba-1
- Transcription factor unc-37
- Paired amphipathic helix protein sin-3
Sequence:
MNSNGPLMEHGKRRVAYYYDSNIGNYYYGQGHVMKPHRIRMTHHLVLNYGLYRNLEIFRPFPASFEDMTRFHSDEYMTFLKSANPDNLKSFNKQMLKFNVGEDCPLFDGLYEFCQLSSGGSLAAATKLNKQKVDIAINWMGGLHHAKKSEASGFCYTNDIVLGILELLKYHKRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGDFFPGTGDLKDIGAGKGKLYSVNVPLRDGITDVSYQSIFKPIMTKVMERFDPCAVVLQCGADSLNGDRLGPFNLTLKGHGECARFFRSYNVPLMMVGGGGYTPRNVARCWTYETSIAVDKEVPNELPYNDYFEYFGPNYRLHIESSNAANENSSDMLAKLQTDVIANLEQLTFVPSVQMRPIPEDALSALNDDSLIADQANPDKRLPPQITDGMIQDDGDFYDGEREGDDRRNESDAKRAAQFESEGGEKRQKTE
Protein: Beta-glucuronosyltransferase GlcAT14C (EC 2.4.1.-) (GT14 family glucuronic acid transferase 3) (AtGlcAT14C) (Q8S8P3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Beta-glucuronosyltransferase involved in the biosynthesis of type II arabinogalactan (AG). Modifies both the beta-1,6-linked galactan and beta-1,3-linked galactan present in type II AG.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9FLD7}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Probable xyloglucan galactosyltransferase GT14
- Beta-arabinofuranosyltransferase RAY1
- Beta-1,6-galactosyltransferase GALT29A
- Beta-1,6-galactosyltransferase GALT31A
- Hydroxyproline O-galactosyltransferase GALT2
- Hydroxyproline O-galactosyltransferase GALT5
- Fucosyltransferase 6
- Probable fucosyltransferase 4
- Beta-1,3-galactosyltransferase 7
- Hydroxyproline O-galactosyltransferase HPGT3
Sequence:
MKRSHISSPRSYSRPAISIFGVFLLFLLVLTLSSRKPSDSSSGLAPNRNLATKSTIPRFAYLVTGTKGDGKRVKRLLKAIHHPRNYYLLHLDLEASDEERMELAKYVRSEKKKFENVMVMGLADLVTEKGPTMLASTLHGVAILLKKAKDWDWFINLSASDYPLMPQDDILHIFSYLPRYLNFIEHTSNIGWKENQRARPIIIDPGFYHLKKSGVFWAKERRSLPASFKLFMGSTSVALTRPFLEFCIWGWDNLPRTLLMYYTNFLLSSEGYFQTVVCNNKDYQNTTVNHDLHYTKWDPLQQRTLNVTVENFRDMVQSGAPFAREFREDDLVLDKIDIELLGQTDTGLELKTPDVVKPTVSWKRLEKLMVRLLDHENFRAKQCK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (D3ZDV9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Protein fantom
Sequence:
MPQAAYCYLRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHSDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSAELAELIRTMLSRRPEERPSVRSILRQPYIKHHISLFLEATKAKTSKNNVKNCDSRAKPVAAVVSRKEEPNHEMIPYQPRSSEGSAVHATGEDKCLSQEKPVDIGPLKSPASLEGHTGKQDMNRTAESCATVSRINIDILPAERRDSAKDGTVEEGRPQHVDASNEVDRQCSISQEKERLQGNSKSSDQPENLLPRWSSGGGDGEGNELVKLLYSSGKDQKPQQDQVTSGCILEDQDSIHPRLQPHSSVSEPSLSRQRRQRKREQTNHGRAKSQLQESPPRLVPSHPDTGKADIISTQQSDGNQSGPVARSVNGSRSSSTASSKDRPLSARERRRLKQSQEEMLPSGPAVQRTPSSVEPVKPQEEDQPIPAQRFSSDCNITQVNPTLLREKKRLIHGLSEDELSSSTSSTDKSDGDSREGKSHTNEMRDLVQLMTQTLRLEAKESCEDLHVPNPGSEFRLHRKYRDTLVLHGKAAEEGEPPCVELPPGITPGSEKIRRIVEVLRADVIQGLGVQLLEQVYDLLEEEDELEREARLQEHMGDKYTTYSVKARQLKFFEENVSF
Protein: Dynein light chain roadblock (Q9VQA6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR009998}.
Interaction partners:
- Dynein light chain roadblock
- Dynein light chain roadblock
- Tctex1 domain-containing protein 2
- Dynein light chain
- Sperm-specific dynein intermediate chain 1, isoform A
- GH16657p
- Sperm-specific dynein intermediate chain 2, isoform A
- FI08533p
- Dynein light chain Tctex-type
- Dynein light chain 2, cytoplasmic
Sequence:
MSAEVEELLKRFQSMKNVTGIVVVDNDGIPIKTTLDYTLTLHYAALMQTVREKARQVVLDLDATNEFTFLRLRTEQNEVMLCPQEDYFIMVIQSPCD
Protein: ATPase family associated with various cellular activities (AAA) (F4HY43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAPVLQSSQPWVEKYRPKQVKDVAHQEEVVRVLTNTLQTADCPHMLFYGPPGTGKTTTALAIAHQLFGPELYKSRVLELNASDDRGINVVRTKIKDFAAVAVGSNHRQSGYPCPSFKIIILDEADSMTEDAQNALRRTMETYSKVTRFFFICNYISRIIEPLASRCAKFRFKPLSEEVMSNRILHICNEEGLSLDGEALSTLSSISQGDLRRAITYLQSATRLFGSTITSTDLLNVSGVVPLEVVNKLFTACKSGDFDIANKEVDNIVAEGYPASQIINQLFDIVAEADSDITDMQKAKICKCLAETDKYNLCPLRNGSRLLMQILLELDLCLKTYETIIV
Protein: Non-specific lipid transfer protein GPI-anchored 31 (AtLTPG-31) (Protein LTP-GPI-ANCHORED 31) (Xylogen protein 1) (AtXYP1) (Q8VYI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable lipid transfer protein (By similarity). Proteoglycan-like factor that exhibits xylogen activity consisting in mediating local and inductive cell-cell interactions required for xylem differentiation.
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.
Interaction partners:
- Early nodulin-like protein 10
- Early nodulin-like protein 15
- Non-specific lipid transfer protein GPI-anchored 7
- At1g62510
- At5g38195
- GDSL esterase/lipase At1g09390
- Early nodulin-like protein 4
- GDSL esterase/lipase At5g62930
- GDSL esterase/lipase LIP-4
- Early nodulin-like protein 11
Sequence:
MATHSSFTATTPLFLIVLLSLSSVSVLGASHHHATAPAPSVDCSTLILNMADCLSFVSSGGTVAKPEGTCCSGLKTVLKADSQCLCEAFKSSASLGVTLNITKASTLPAACKLHAPSIATCGLSVAPSTAPGLAPGVAAAGPETAGFLAPNPSSGNDGSSLIPTSFTTVLSAVLFVLFFSSA
Protein: Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) (Q8BGG7)
Organism: Mus musculus (Mouse)
Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}.
Interaction partners:
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- E3 ubiquitin-protein ligase CBL
Sequence:
MAAREELYSKVTPRRDRLQRPGTVKHGSALDVLLSMGFPRARAQKALASTGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQICGKNKAHNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSNFIGLFVKEDSAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASHLPTLEKLAQNIDVKLGCDWVATIFSRDIRFANHETLQVIYPYSPQNDDELELVPGDFIFMSPMEQTSTSEGWIYGTSLTTGCSGLLPENYITKADECSTWIFHGSYSILNTVSSSSLAFGDGALERRQYEDQGLGETTPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYWLSQCFDAKGRYIRTNLNMPHSLPQRSGGFRDYEKDAPITVFGCMQARLVGEALLESNTVIDHVYCSPSLRCVQTAHNILKGLQQDNHLKIRVEPGLFEWTKWVAGSTLPAWIPPSELAAANLSVDTTYRPHIPVSKLAISESYDTYINRSFQVTKEIISECKSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFVQMVRKIPYLGFCSCEELGETGIWQLTDPPILPLTHGPTGGFNWRETLLQE
Protein: 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase (EC 1.3.1.87) (2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase) (3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase) (CI-dihydrodiol dehydrogenase) (Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase) (Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase) (PP-dihydrodiol dehydrogenase) (P0CI31)
Organism: Escherichia coli (strain K12)
Function: Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.
Interaction partners:
- 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit
- 3-phenylpropionate/cinnamic acid dioxygenase subunit beta
- 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD
- 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha
- 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
- 3-
- 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase
- HTH-type transcriptional regulator MalT
- Diaminopropionate ammonia-lyase
- Recombination-promoting nuclease RpnA
Sequence:
MSDLHNESIFITGGGSGLGLALVERFIEEGAQVATLELSAAKVASLRQRFGEHILAVEGNVTCYADYQRAVDQILTRSGKLDCFIGNAGIWDHNASLVNTPAETLETGFHELFNVNVLGYLLGAKACAPALIASEGSMIFTLSNAAWYPGGGGPLYTASKHAATGLIRQLAYELAPKVRVNGVGPCGMASDLRGPQALGQSETSIMQSLTPEKIAAILPLQFFPQPADFTGPYVMLTSRRNNRALSGVMINADAGLAIRGIRHVAAGLDL
Protein: WW domain-containing transcription regulator 1 (WW domain-containing transcription regulator protein 1) (Q307I6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- non-specific serine/threonine protein kinase
- Protein salvador homolog 1
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase 3
- TEA domain family member 1a.
- Angiomotin.
- Tight junction protein 2a
- Dishevelled segment polarity protein 2.
- MOB kinase activator 1Ba)
- Angiomotin-like 2a
Sequence:
MSGNPLQPIPGHQVIHVAKDLDTDLEALFNSVMNPKPSSWRNKDMPQSFFQEPDSGSHSRQSSADSGSLPPRVHFRSRSSPASLQLPAGSVSGPSPGRLHSHTRHQSCDVAEELPLPPGWEMAFTPNGQKYFLNHIEKITTWHDPRKSMTPSVAQLSLHNQVSNTASIQQRSMALSQPNLVLNQQAHQQQQQHLQQQQQQVPVQVPVQAPQQQSSQPMMNLSAQQHQQKMRLQRIQMERERIQRRQEELMRQEVALRQLPMDSDNLPPVAPAIGSPAMSAGNMPNNSADPFLNSGPYHSREQSTDSGLGLGCYSIPTTPEDFLNNMEDMDTGENMVPVSMNVPPQSRFPDFLDSMPGTNVDLGTLEGTDLMPILNDVESVLNKSEPFLTWL
Protein: 60S ribosomal protein L13 (Q6FL18)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein eL43
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS28
- 40S ribosomal protein S24
- Candida glabrata strain CBS138 chromosome G complete sequence
- YL17
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome G complete sequence
Sequence:
MAISKNLPILKNHFRKHWQERVKVHFDQAGKKESRRSARVAKAAKIAPRPLDLLRPVVRAPTVKYNRKVRAGRGFSLAEIKAAGLTAAYARTVGIAVDHRRQNRNQETFDLNVQRLKEYQSKLIVFPRKGKAPETEQVLSVAATFPIAQASTEIETRAVEDNGESAFRTLRLARSDKKFKGIREKRAREKAEAEAEKKK
Protein: StAR-related lipid transfer protein 5 (START domain-containing protein 5) (StARD5) (Q9NSY2)
Organism: Homo sapiens (Human)
Function: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).
Interaction partners:
- Phosphatidylcholine transfer protein
Sequence:
MDPALAAQMSEAVAEKMLQYRRDTAGWKICREGNGVSVSWRPSVEFPGNLYRGEGIVYGTLEEVWDCVKPAVGGLRVKWDENVTGFEIIQSITDTLCVSRTSTPSAAMKLISPRDFVDLVLVKRYEDGTISSNATHVEHPLCPPKPGFVRGFNHPCGCFCEPLPGEPTKTNLVTFFHTDLSGYLPQNVVDSFFPRSMTRFYANLQKAVKQFHE
Protein: Candida glabrata strain CBS138 chromosome D complete sequence (Q6FVW6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Kinesin-like protein CIN8
- Candida glabrata strain CBS138 chromosome H complete sequence
- Very long-chain fatty acid transport protein
- Candida glabrata strain CBS138 chromosome H complete sequence
- ADP-ribosylation factor
- ADP-ribosylation factor
- Tubulin beta chain
- Dynein heavy chain, cytoplasmic
- Candida glabrata strain CBS138 chromosome H complete sequence
- Candida glabrata strain CBS138 chromosome L complete sequence
Sequence:
MDEPATPAKQTGIGGAGQKRRYTTTPPREIRQYQSRSSFGVNSSGNVDGKSIRSRTHLTSFYKENVMELNELQDKLFQKKGVLDGLKDEYEDLKSRYTALDLKWEQKKEERKLKAQKLELKEKELKKIKDDFANKKTFLEESHKLKLEQLTANKNAELNKMNDEYRSKLEALKYEKIKKFENEKNELIEKIEEIRNKMITNDVALQQRMKDIEADHLEEKEKWLKDYQKEWREVTEKNQESIRKTKELKSEIETVLTPRIDTQNKRLEELKSEIKKLDDTLQNKNEQVGEIRKNIDLEREKKDKLLAEKEEILAYIEKSKKEVEEIKKILVKEESLRRALHNELQELRGNIRVYCRIRPPLPHEDDNIEHIKVQPFDDDNGDQGMTINRGNSQVIPFKFDKIFDQQETNDEIFKEVGQLIQSSLDGYNVCIFAYGQTGSGKTYTMLNPGDGIVPATINHIFSWIDKLAARGWSYKVSCEFIEIYNENIVDLLRSGAPSQENNDRNADSKHEIRHDQELKTTYITNITTCVLDSRDTVDKVLKRANKLRSTASTAANEHSSRSHSIFIIHLEGKNEGTGEKSQGILNLVDLAGSERLNSSMVVGERLRETQSINKSLSCLGDVIHALNSPDGQKRHIPFRNSKLTYLLQYSLIGSSKTLMFVNISPAALHLNETINSLRFASKVNNTKMITRN
Protein: Neurotrophin receptor-interacting factor 1 (Neurotrophin receptor-interacting factor) (Zinc finger protein 110) (Q923B3)
Organism: Mus musculus (Mouse)
Function: Transcription regulator involved in NGFR/p75(NTR)-mediated apoptosis. Essential component of the NGFR/p75(NTR) apoptotic pathway: upon ligand-binding and subsequent cleavage of NGFR/p75(NTR), binds to the intracellular domain (ICD) cleavage product of NGFR/p75(NTR), translocates to the nucleus and induces apoptosis, possibly by regulating expression of key regulators of apoptosis. Induces NGFR/p75(NTR)-mediated apoptosis in retina and sympathetic neurons. May also regulate expression of neuronal cholesterol biosynthesis genes. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression.
Subcellular location: Cytoplasm. Nucleus. Note=Translocates into the nucleus following binding to TRAF6 and subsequent ubiquitination at Lys-15.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 16
- TNF receptor-associated factor 6
- Neurotrophin receptor-interacting factor 2
- Melanoma-associated antigen D1
- Protein BEX3
Sequence:
MASTLPTTWPHESVKFEDVSLTFTEEEWAQLDFQQKCLYREIMMENYSNMISVEHHFSKPNVISQLEKAEDCWPMQREIPQDTLPECSWPSPDPGMNSFPSKSPLMKIEVVEVLTLNKDVAGPRNALIQSLYPEDLNPGNLKPAQQPSKRLTDTEASRQKFRHFQYEESAGPQKAMSQLRKLCHQWLQPNTRSKKQILELLVLEQFLNALPEKFRVWVESQHPEDCKAVVALLENMTSVSKDDASLACSSEATDQLKEKRKGVATLPVTFAAEVPAEEPVTFQDVAVDFNEEEWRLLGPTQKTEYHDVMLETLGNLVSVGWEPTLGNRELTPDSPIPVVKPIHDPNTNDLSRNGTQSTVFESILEDGVKEMHSIESNQVGNLQEKGHPQKKFSESSKSQDQTSRHKSQGSLNEVLPRKYVKVKQKGTGKRKGRTNTISMTRGLRIRKQQKDSVEWQGRSGSTPVTHGSSIKKQQQGSEQGKPGTSRDPITLTVPAKVYQKATGSEESIFMDSSDAMVPDVPPKIHQKGPEWHKVGESNNSMLQGSSVQNHQMESGAGRASDNSLLTHALPVKSHQKGYKEGNVQGNRNSWKHIKPHQKGSKGERVEELSTSEKHVPYVKNHLKTSERGKDREINASIKCDPYIKTYYRGSDVGRLRRANNCRKAFSLHAQQISFIKIHKGSQVCRCSECGKLFRNARYFSVHKKIHTGERPYMCMACGKAFVQSSSLTQHLRIHSGERPFECSECGRTFNDRSAISQHLRTHTGAKPYHCERCGKAFRQSSHLTRHERTHTGERPYVCIKCGKAFTQSSHLIGHQKTHGIKFKKQPKL
Protein: Adaptor-related protein complex 1 associated regulatory protein (A0A0G2JG85)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGNCCWTQCFGLLRREAGRLQRAGGGSKYFRTCPRGEHLTIEFENLVESDEGESPGSSHRPLTEDEIADLQERHYDSIAEKQKDVDRKIQRQQEKQRVAQHYHCSSGDYQSAGPEDDFESSLRNIKSQYEVFRSSRLSSDATVLTPNTESSCDLMTKTKSTSGNDDSTSLDLEWEDEEGMNRMLPMRERSKTEEDILRAALKYSSKKGSNPTSASDDSNGLEWENDFVSAEMDDNGNSEYSGFVNPVLELSDSAIKQSDTDQQIR
Protein: Large ribosomal subunit protein mL53 (39S ribosomal protein L53, mitochondrial) (A1Z9J6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Small ribosomal subunit protein mS33
- Meiotic recombination protein P22
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein mL51
- Large ribosomal subunit protein uL4m
- GH05406p
- Large ribosomal subunit protein uL22m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL10m
Sequence:
MSVPFSGALRRSGGIVSAIGKQLKSVNLKGVKRITVQFDPFAENVKSTREFLFLLSTPKVAATNPKCVVKPEIVCDRQPANIKFALIDSAQEQAQVKEIRFNSDNLNTLELLQLCNKHVSSLAPREEITNKVLTKAEKQKLAGGAGGGKKATKKK
Protein: Catalase T (EC 1.11.1.6) (P06115)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Aldehyde dehydrogenase [NAD
- Peroxisomal catalase A
- Superoxide dismutase
- 12 kDa heat shock protein
- Meiotic sister chromatid recombination protein 1
- Glutathione reductase
- Glutamate--cysteine ligase
- Superoxide dismutase, mitochondrial
- Glutathione peroxidase-like peroxiredoxin 1
- Reticulon-like protein 2
Sequence:
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
Protein: Small ribosomal subunit protein bS21m (28S ribosomal protein S21, mitochondrial) (MRP-S21) (S21mt) (P82921)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25838379}.
Interaction partners:
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein bS6m
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein mS27
- Small ribosomal subunit protein mS33
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein mS31
Sequence:
MAKHLKFIARTVMVQEGNVESAYRTLNRILTMDGLIEDIKHRRYYEKPCCRRQRESYERCRRIYNMEMARKINFLMRKNRADPWQGC
Protein: Blue copper protein (Blue copper-binding protein) (AtBCB) (Phytocyanin 1) (Stellacyanin) (Q07488)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as an electron carrier.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
- Senescence-associated protein 13
- At1g31750
Sequence:
MAGVFKTVTFLVLVFAAVVVFAEDYDVGDDTEWTRPMDPEFYTTWATGKTFRVGDELEFDFAAGRHDVAVVSEAAFENCEKEKPISHMTVPPVKIMLNTTGPQYFICTVGDHCRFGQKLSITVVAAGATGGATPGAGATPAPGSTPSTGGTTPPTAGGTTTPSGSSGTTTPAGNAASSLGGATFLVAFVSAVVALF
Protein: Pentatricopeptide repeat-containing protein At3g06430, chloroplastic (Protein EMBRYO DEFECTIVE 2750) (Q9SQU6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- At4g25020
- Proteinaceous RNase P 1, chloroplastic/mitochondrial
- Proteinaceous RNase P 3
- Proteinaceous RNase P 2
- Ribonuclease III domain-containing protein RNC1, chloroplastic
- AT3g56990/F24I3_70
- Probable non-intrinsic ABC protein 5
Sequence:
MASMSLSFSSSLCSSRIPEGKRRFRHRDVGIVRCVLAASKSSPGSVTKKRLWKDGEFPGITEPVNQRRTPIKNVKKKLDRRSKANGWVNTVTETLSDLIAKKQWLQALEVFDMLREQTFYQPKEGTYMKLLVLLGKSGQPNRAQKLFDEMLEEGLEPTVELYTALLAAYTRSNLIDDAFSILDKMKSFPQCQPDVFTYSTLLKACVDASQFDLVDSLYKEMDERLITPNTVTQNIVLSGYGRVGRFDQMEKVLSDMLVSTACKPDVWTMNIILSVFGNMGKIDMMESWYEKFRNFGIEPETRTFNILIGSYGKKRMYDKMSSVMEYMRKLEFPWTTSTYNNIIEAFADVGDAKNMELTFDQMRSEGMKADTKTFCCLINGYANAGLFHKVISSVQLAAKFEIPENTAFYNAVISACAKADDLIEMERVYIRMKERQCVCDSRTFEIMVEAYEKEGMNDKIYYLEQERQKLMDRTVATKEMENLPAG