wanglab/gogpt-training-data huggingface dataset:
Protein: Vacuolar protein sorting-associated protein 41 homolog (B4DR83)
Organism: Homo sapiens (Human)
Subcellular location: Endosome membrane {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR028921}. Late endosome membrane {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR028921}. Early endosome membrane {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR028921}. Lysosome membrane {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR028921}. Golgi apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601, ECO:0000256|PIRNR:PIRNR028921}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000256|PIRNR:PIRNR028921}. Late endosome {ECO:0000256|ARBA:ARBA00004603}.
Interaction partners:
Sequence:
MGVCSEDGKVQVFGLYSGEEFHETFDCPIKIIAVHPHFVRSSCKQFVTGGKKLLLFERSWMNRWKSAVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDIISKQRITNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSVKVCSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEISEKTEREYCARPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYIVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQKNIKRHKILDIGLAYINHLVERGDYDIAARKCQKILGKNAALWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEEALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPSDAAKPFSVVVFHCRHMFHKECLPMPSMNSAAQFCNICSAKNRGPGSAILEMKK
Protein: Formate hydrogenlyase subunit 6 (FHL subunit 6) (Hydrogenase-3 component F) (P16432)
Organism: Escherichia coli (strain K12)
Function: Probable electron transfer protein for hydrogenase 3.
Interaction partners:
- Formate hydrogenlyase subunit 4
- Formate hydrogenlyase subunit 7
- NADH-quinone oxidoreductase subunit C/D
- Formate hydrogenlyase subunit 2
- Formate dehydrogenase H
- Formate hydrogenlyase subunit 3
- Formate hydrogenlyase subunit 5
- Hydrogenase 3 maturation protease
- NADH-quinone oxidoreductase subunit H
- NADH-quinone oxidoreductase subunit B
Sequence:
MFTFIKKVIKTGTATSSYPLEPIAVDKNFRGKPEQNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGHCIFCGRCEEVCPTAAIKLSQEYELAVWKKEDFLQQSRFALCNCRVCNRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKRQKCLVPSDRIELTRHMKEAI
Protein: Stretchin-MLCK (Q9GTV1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNDYGVEAAAASVAVEGPPEPPSAQPSVSLGPDRVAVAWCGPPYDGGCMITGFIIEMQTIGDENCDEDSWQQVTRVVDSLAYTVKNLQPQRQYRFRVRAENIHGRSAPGQASELVQITSTPQRNTSSDASDRFGQATVSVQSGGDFKSRFEIIEELGKGRFGIVYKVQERCQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKLLQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLESKWLSQRPDDSLSNNKICTDKLKKFIIRRKWQKTGNAIRALGRMANLSVSRRNSAIAMGVLSSPRPSISGLGMLTTSAIGSGTSSQMTSLHEEEDDFSGEMPPVEKRTVLKLRDKSQCSERSDSGYSECSNCSGAQETLLLSLAKSKLEAIAKASTLPTVVHDTEQPVSLELPTKGEAIMRSDFTNTIKMRKKSLEDSAAREKPRSKPQVKPLLSEEPGRSGRGAPSVSGKGKSPQVRSMPSSPLPQRSATPTRLMSQRVREAAERLAQQHTVASAQRHLGNGRGTGTGNGNGNSNSNGNGNGNTAETNRESRARRLINRFNSETQHITS
Protein: Thymidine kinase, cytosolic (EC 2.7.1.21) (P04183)
Organism: Homo sapiens (Human)
Function: Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT).
Subcellular location: Cytoplasm.
Interaction partners:
- Thymidylate synthase
- Thymidylate kinase
- Thymidine kinase 2, mitochondrial
- Thymidine phosphorylase
- Deoxycytidine kinase
- Cytidine deaminase
- Baculoviral IAP repeat-containing protein 5
- Ribonucleoside-diphosphate reductase subunit M2
- Outer kinetochore KNL1 complex subunit ZWINT
- Dihydrofolate reductase
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
Protein: Transcription elongation factor 1 homolog (Q9XVZ8)
Organism: Caenorhabditis elegans
Function: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription elongation factor SPT5
- Transcription elongation factor SPT4
- Repressor of RNA polymerase III transcription MAF1
- FACT complex subunit spt-16
- Cell division cycle protein 73
- IWS1-like protein
- DNA-directed RNA polymerase II subunit RPB2
- RNA polymerase-associated protein LEO1
- DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein
- Suppressor of Ty 6 homolog
Sequence:
MGKRKSKRKAPTKAKAVMPLDTQFNCPFCNHERVCEVKMDREKNVGYISCRVCSEDFQTNINYLSEPIDVYSDWVDACEQANNA
Protein: Uncharacterized transporter YBR287W (P38355)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Sec sixty-one protein homolog
- Choline kinase
Sequence:
MVETFSFAHLAYLVFESVLQVVIIALAGFWSASSGLLPKQSQKIISLLNVDLFTPCLIFSKLAKSLSMAKIFEIAIIPIFFGLTTGISFISGKIMSRILDLDKDETNFVVANSVFGNSNSLPVSLTLSLAYTLPNLTWDQIPNDNRDNVASRGILYLLIFQQIGQMLRWSWGYNKLMKWSGENTQHMPPSQVQSLLERTPNIDNEELVNEEQEEQELLEEENNRMNSSFLSSSSIGDKIWQKSCTVFERIRANLNPPLYSMIFAVVVAAIGPLQRELFMEDGFINNTFAEAVTQLGSVSIPLILVVLGSNLYPSAEVFPKTVHHSKLLIGSIIGRMILPSCFLLPIIAIAVKYINVSILDDPIFLVVGFLLTVSPPAIQLTQITQLNEFFEAEMADILFWGYAVLSLPVSIIVVSGAIYVLQWANPT
Protein: General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 (TFIIH subunit XPB/SSL2) (EC 5.6.2.4) (DNA 3'-5' helicase/translocase XPB/SSL2) (DNA repair helicase RAD25/SSL2) (RNA polymerase II transcription factor B subunit SSL2) (TFB subunit SSL2) (Suppressor of stem-loop mutation 2) (Q00578)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/SSL2, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/SSL2 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. XPB/SSL2 acts as a double-stranded DNA translocase promoting DNA opening by tracking along the nontemplate promoter strand, rotating and inserting DNA into the Pol II active site cleft, leading to DNA unwinding. May also use this translocase mechanism during DNA repair rather than physically wedging open damaged DNA.
Subcellular location: Nucleus.
Interaction partners:
- General transcription and DNA repair factor IIH subunit TFB4
- Cyclin CCL1
- RNA polymerase II transcription factor B subunit 3
- Transcription initiation factor IIB
- DNA repair protein RAD2
- General transcription and DNA repair factor IIH helicase subunit XPD/RAD3
- General transcription and DNA repair factor IIH subunit TFB6
- General transcription and DNA repair factor IIH subunit TFB1
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor IIE subunit alpha
Sequence:
MTDVEGYQPKSKGKIFPDMGESFFSSDEDSPATDAEIDENYDDNRETSEGRGERDTGAMVTGLKKPRKKTKSSRHTAADSSMNQMDAKDKALLQDTNSDIPADFVPDSVSGMFRSHDFSYLRLRPDHASRPLWISPSDGRIILESFSPLAEQAQDFLVTIAEPISRPSHIHEYKITAYSLYAAVSVGLETDDIISVLDRLSKVPVAESIINFIKGATISYGKVKLVIKHNRYFVETTQADILQMLLNDSVIGPLRIDSDHQVQPPEDVLQQQLQQTAGKPATNVNPNDVEAVFSAVIGGDNEREEEDDDIDAVHSFEIANESVEVVKKRCQEIDYPVLEEYDFRNDHRNPDLDIDLKPSTQIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIVLCTSSVSVMQWRQQFLQWCTLQPENCAVFTSDNKEMFQTESGLVVSTYSMVANTRNRSHDSQKVMDFLTGREWGFIILDEVHVVPAAMFRRVVSTIAAHAKLGLTATLVREDDKIGDLNFLIGPKLYEANWMELSQKGHIANVQCAEVWCPMTAEFYQEYLRETARKRMLLYIMNPTKFQACQFLIQYHERRGDKIIVFSDNVYALQEYALKMGKPFIYGSTPQQERMNILQNFQYNDQINTIFLSKVGDTSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYSTKRQAFLVDQGYAFKVITHLHGMENIPNLAYASPRERRELLQEVLLKNEEAAGIEVGDDADNSVGRGSNGHKRFKSKAVRGEGSLSGLAGGEDMAYMEYSTNKNKELKEHHPLIRKMYYKNLKK
Protein: Agamous-like MADS-box protein AGL97 (Q9C633)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcription factor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Chaperonin-like RBCX protein 1, chloroplastic
- Defensin-like protein 81
- Cytochrome P450 family protein
- Cytochrome P450, family 78, subfamily A, polypeptide 8
- Developmental protein SEPALLATA 2
- ceramide glucosyltransferase
Sequence:
MGGVKRKIAIEKIQNKNPRAVSFSKRRKGLYSKASELCLLSDAEIAIIATPVSSNSNAAFYSFGHSSVDNVVAAFLANQRPCDERFWWEDESLLKSENLEELREAMDSMSTMLRDLKELEKQRDHQTQTLIHQPCSARVCIQDYVTVNFDGFNTEEQTLAVSDNSNNNGLLGNLDECNEDFDDLDQIFDTVTNSEFLSVNLEMDDVTVNSEGNTEEQTLAVSDNSNNNGLLGNLDECNEDFDDLDQIIEYLTSSEALSMNLKMDDV
Protein: IP16294p (A2VEG3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTLLGPSAPGMAFMMKKKKYKFNVEVQLQDLVEVALVNEVLFAKIRLLDGGSFQEYSSREEVRNHRVEWNRSFEFPCKMSANASTGVLDPCHLRISIRKEMKGGRSYYKLGFIDLNLAEFAGAGLTSRRFLLEGYDSRHRLDNSMLRVSIKMHMLSGDILFKAPTPNLKSKQSKPSIDDFSNAATGVGLQIPTATALPSIGGGSGGASVSLGGSGVTLGGIPGNQSLPGTRPVSTTKEEDIDNQALIAAIVTDSGLSESSESGVTLTTDNLQQHGSVVVANPISPVTQALPQLGIIGSNNYGTTGGAIGFTGAGNATLIEMGHSRNSSNTSQMSKGSGYSSFSHSQHSRQSSEGDSGHASRQNGQKGDEHQQCNSLRVVVAKSHHVHTHLSLSTTVEYASDEQLYQTPNATMTNSQKLAFEDFRTPMAELAAPLFQPMGAGCSGTPSSTYRSAGSPSHNTQYYDSGEASDTDECLNDESGDNDSGLEENFHTPRVAKIKSMENLSILEMEFHKASMELDRNSPRRLKQLAEHAQIPKMKSLNNLCFDHYAEQSVREEFQRMHEQSLEERMRFQQHHQLRKNSNASNGSATKIYVKHLSHQNHYHIKVGNAKFIGQDGNDSPQSMHYPIQKMRSMGTIQDIVSDRIEPDPFLTPTTERKPNFSRLVQSAEKPVLGSSYVNRLLTYDAVDSPSEPFNSSVSFMSRTPFQRAYRRNIQQGSSSTPLATQDFFAVRPHSTNAAYELMRNPSSGSLVISETGSLDRTKSSGEKRKKGALDDGPRVSDRVEETRVNPDSLIDEILKDTKLDQLEESAETSGLQLYIARDGTASLGGHEVKSSVRAGALKQVVMQDRR
Protein: TLR adapter interacting with SLC15A4 on the lysosome (Q9HAI6)
Organism: Homo sapiens (Human)
Function: Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:31092820, ECO:0000269|PubMed:32433612}. Endosome membrane {ECO:0000269|PubMed:32433612}. Nucleus {ECO:0000269|PubMed:31092820}. Cytoplasm {ECO:0000269|PubMed:31092820}. Note=Recruited to endolysosome following interaction with SLC15A4 (PubMed:32433612). May colocalize with TLR7 in the endosomal pathway (PubMed:31092820). {ECO:0000269|PubMed:31092820, ECO:0000269|PubMed:32433612}.
Interaction partners:
- Solute carrier family 15 member 4
- Toll-like receptor 7
Sequence:
MLSEGYLSGLEYWNDIHWSCASYNEQVAGEKEEETNSVATLSYSSVDETQVRSLYVSCKSSGKFISSVHSRESQHSRSQRVTVLQTNPNPVFESPNLAAVEICRDASRETYLVPSSCKSICKNYNDLQIAGGQVMAINSVTTDFPSESSFEYGPLLKSSEIPLPMEDSISTQPSDFPQKPIQRYSSYWRITSIKEKSSLQMQNPISNAVLNEYLEQKVVELYKQYIMDTVFHDSSPTQILASELIMTSVDQISLQVSREKNLETSKARDIVFSRLLQLMSTEITEISTPSLHISQYSNVNP
Protein: Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (F4K658)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
- Squalene synthase 1
- Phytoene synthase 1, chloroplastic
- At1g62730
- Inactive squalene synthase 2
- Geranylgeranyl diphosphate reductase, chloroplastic
Sequence:
MWRRSFSTLPKKKWDAVVIGGGHNGLTAAAYLARGGLSVAVLERRHVIGGAAVTEEIVPGFKFSRCSYLQGLLRPCIIRELELGRHGLKLLKRSPSSFTPCLDGRYLLLGPDQDLNHSEISKFSKHDADAYPRYEKQLERFCGFMDPLLDSTPPESLQSASSFNDKLSNKMYKSAFWARCLRQAVSLGHKDMVAFMDLLLAPASKVLNNWFESDVLKASLATDAVIGSTASVHTPGSGYVLLHHVMGETDGEKGIWSYVEGGMGSVSMAIANAAKEAGAEIFTNAEVSEILTEDSSIVKGVLLADGTRVESSAILSNATPYRTYVELVPTNVLPENFVSAIKNSDYSSATTKINLAVDKLPQFQCCNTNHSGPGPEHFGTIHIGAESMDEVHSACHDSENGLPSRRPVIEMTIPSTLDNTISPPGKHVINLFIQYTPYKPSDGSWEDPTYREAFAQRCFKLIDEYAPGFSSSIISYDMLTPPDLEREIGLTGGNIFHGAMGLDSLFLMRPVKGWSNYRSPLKGLYLCGSGAHPGGGVMGAPGRNAAHVVLQDLKRI
Protein: Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) (Q5VVJ2)
Organism: Homo sapiens (Human)
Function: Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:17707232}. Cytoplasm {ECO:0000250|UniProtKB:Q69Z66}. Note=Localizes to the cytoplasm in response to bacterial infection. {ECO:0000250|UniProtKB:Q69Z66}.
Interaction partners:
- Histone acetyltransferase KAT2B
- Histone H2A type 2-C
- Protein polybromo-1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- Histone H2A type 2-A
- Histone acetyltransferase p300
- 26S proteasome non-ATPase regulatory subunit 6
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome regulatory subunit 4
- Proteasome subunit beta type-2
Sequence:
MAAEEADVDIEGDVVAAAGAQPGSGENTASVLQKDHYLDSSWRTENGLIPWTLDNTISEENRAVIEKMLLEEEYYLSKKSQPEKVWLDQKEDDKKYMKSLQKTAKIMVHSPTKPASYSVKWTIEEKELFEQGLAKFGRRWTKISKLIGSRTVLQVKSYARQYFKNKVKCGLDKETPNQKTGHNLQVKNEDKGTKAWTPSCLRGRADPNLNAVKIEKLSDDEEVDITDEVDELSSQTPQKNSSSDLLLDFPNSKMHETNQGEFITSDSQEALFSKSSRGCLQNEKQDETLSSSEITLWTEKQSNGDKKSIELNDQKFNELIKNCNKHDGRGIIVDARQLPSPEPCEIQKNLNDNEMLFHSCQMVEESHEEEELKPPEQEIEIDRNIIQEEEKQAIPEFFEGRQAKTPERYLKIRNYILDQWEICKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFGCEQAVYNRPQTVDKVRIRDRKDAVEAYQLAQRLQSMRTRRRRVRDPWGNWCDAKDLEGQTFEHLSAEELAKRREEEKGRPVKSLKVPRPTKSSFDPFQLIPCNFFSEEKQEPFQVKVASEALLIMDLHAHVSMAEVIGLLGGRYSEVDKVVEVCAAEPCNSLSTGLQCEMDPVSQTQASETLAVRGFSVIGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAKFIGMIVSPYNRNNPLPYSQITCLVISEEISPDGSYRLPYKFEVQQMLEEPQWGLVFEKTRWIIEKYRLSHSSVPMDKIFRRDSDLTCLQKLLECMRKTLSKVTNCFMAEEFLTEIENLFLSNYKSNQENGVTEENCTKELLM
Protein: Mitochondrial RNA binding protein (Q38A74)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGLPFLCHTRVCLFSNKIPFVLCGSRFAPATLHAHHTAAGGGETLNFPELSSPSTSKEPSVGSDSPQKKNKKQAFDALARWCGGHQQLLMRIQQSAEDTSAGVVFETPLTEVDSAAIRWLQGSTEQLTCGQSLLVCSFVCEVLYCQLNSASGGIGVEEAQRLQIHALTNRIAALLQRADESNKLESQPLSVLMSCAYVVQRLKYVDNPLFGETQRSLVKVPPSIMFALLHKLRGDGLGKLFQLDERTATDVCLSFLFIATEEHRQAFFSSGDAALVSNVLRRLVRHTASKTRRMRIQKEGDIIDLLTVDSPSDGDARQTPVCTSGTGFTSPSMRECAMIMQNVSFSSPSNRLELLLYLLCVRRNLAQCSLKDIELVPTVLSTVANIRSAEACSIRKKIISQLWLPENNPTLVAQLLVHSGESIPRYVTYLQGVPPSKLSPGDATQVILCAGTYLSYESLQLYIMAALRDIMPSSSLITLGAETTSASVPATASVPTRVPACDSLETVLSVLLMRVEEKGGSLSEVEKDACMEYIRRLNELIDWCASAPTSSPKLALQRLMLLTKLFNRGLVVHAPETVVELAVQSLQLDPGNTMMNTLKCVSEALPLVSDDKKRSIIIEKMISYSGTRTTSSVIRFLLLLAPLVDADSPHSCELVEQLLKFHTLNPHKLRQASVEGVAKGIDVYTLLLINGIDFLLASGDWRSSPSQLQNVITTWVRDYTLYVMDPARKQKIDDGTAAHVAPATKGEKTDVVQHQQPSRLNEGGELPTLSGPNDDELEQVFTCLLRAGVKLPHAFSSELLSRIHRLQAKQNPADGTDQQVVFPLPAHFVFCCKLDVPVEVSVTPEMMKYHIDACDYRIIHCVITAFFSAAGTFKHNINDLLLCNMRLASRSFELFIQRLGEEASRSFRPATVSSVVANTLRFVVNHITKQERCQRVLRKLNEKGGIEAGEELEGDRSLIVEHTRLGELLTRMIAYLSGAHVKNVGLSVLDRLSLLSPACGEYLMMRLSTQLSEFTQVELLYLVQKYPKSQDLVAELLGKSDLVSSMDFGDYMRVMRNLPMSINALVIGAHLPGLNFQWCTRILSSLSVRHESVPLHLLASVLRRLNDVTESATLTDRNIAFVVLQKYLQFDQTSGDGGDLEERQRLIKCSCDKLLVLSRINSLDTLKEFLVEFPEALSGVICESLSKHVVQHIVGGLLKDLDGLLTLCRLLHRHKLLTSDVKVAIVDGFFMKTLQSEVEGRANIEGESSQGLQPLNSLRGASLKTTHPVSNVLALALLLSDGPLHFPGASNSSSTICGDNERCAVSSMFQVVKESYTSPRDRLLIANTLVGQKGPNALTVVAKEICTELIENCESVTSNDFSRLLQCISRLKCWSELDLANSRFDEVFQRSCTQADAHSRCVAFRAVSFEADIFRRYESFMIPLLQETVDVMSNEDLETVLSSVLSLPFTEALESLIDAIGTRLLRMIDQCRRSALIRLLQCHAVFGIQDDALVSICVATLTDQCGRDFRLDTAQVLALLQAAVDLDFFLPPKLVTSCFTWLEHHVENMTITQLGHAVRLAVDVEVGYTAAVHTLTLRALEQRDAIRSNASFREAVEMLCDEFSAEIPWHLRAPVLRRRYQSERLLEYLDKRRLAVDSTVA
Protein: Collagen alpha-2(XI) chain (Q64739)
Organism: Mus musculus (Mouse)
Function: May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Interaction partners:
- Collagen alpha-1
- Procollagen C-endopeptidase enhancer 1
- Collagen alpha-1
- Collagen alpha-2
- Collagen alpha-1
- Lumican
- Collagen, type IX, alpha 3
- Collagen alpha-1
- Collagen alpha-2
Sequence:
MERCSRCHRLLLFLPLVLGLSAAPGWAGAPSVDVLRALRFPSLPDGVRRSKGVCPGDVAYRVARPAQLSAPTRQLFPGGFPKDFSLLTVVRTRPGLQAPLLTLYSAQGVQQLGLELGRPVRFLYEDQRGRPQASAQPIFRGLSLADGKWHHVAVAVKGQSVTLIVDCKKRVTRPLPRSVHPVLDTHGVVIFGAHILDDEVFEGDVQELLVVPGVQAAYQSCGQKDLECEREQRDGPQTQKPHRAQRSPKKEPARLHKPQSQEPQKQPTESLYYDYEPPYYDVMTTGTAPDYQYPTPGEEEGVLESSPLPFLEEEQTDLQVSPTADSFQAEEYGEGGTDSPAGFYDYTYGYGDDYREETELGPALSAETAHSGAVAHGPRGLKGEKGEPAVLEPGMFVEGPPGPEGPAGLAGPPGIQGNPGPVGDPGERGPPGRAGLPGSDGPPGPPGTSLMLPFRFGSSGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSPGLKGESGDLGPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGEPGMKGDRGFDGLPGLPGEKGQRGDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPHGPKGSLGPQGEPGPPGQQGTPGAQGLPGPQGAIGPHGEKGARGKPGLPGMPGSDGLPGHPGKEGPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPGSRGEDGPEGPKGRTGPTGDPGPTGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPAGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGTAGESGPMGERGHSGPPGPPGEQGLPGTSGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNEGPAGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDGGPMGPPGPPGPRGPAGPNGADGPQGSPGGVGNLGPPGEKGEPGESGSPGVQGEPGVKGPRGERGEKGESGQAGEAGPPGPKGPTGDNGPKGNPGPVGFPGDPGPPGEAGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGTPGPEGRQGEKGAKGDPGAVGAPGKTGPVGPAGLAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLIGLIGPTGEQGEKGDRGLPGPQGSPGQKGETGIPGASGPIGPGGPPGLPGPSGPKGAKGATGPAGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRSVDGSKLIQDEEAVPTGGAPGSPAGLEEIFGSLDSLREEIEQMRRPAGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCARDAFRVFCNFTAGGETCVTPRDDVTQFSYVDSEGSPVGVVQLTFLRLLSVSAHQDVSYPCSGVSQDGPLKLRGANEDELSPETSPYVKEFRDGCQTQQGRTVLEVRTPVLEQLPVLDASFADLGAPTRRGGVLLGPVCFMG
Protein: Rhodanese domain-containing protein (Q38EP7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- C2H2-type domain-containing protein
- Uncharacterized protein
- AMP-dependent synthetase/ligase domain-containing protein
- Large ribosomal subunit protein uL4m
Sequence:
MAQWVPKTAWKVSNLNKRYGPGYITSGFSSENTLGYTHMVHDSHKLREKLSSRKGIFVIDVRDPGERKLNPVPRSVALHHHDLLSGASCPILPQQKSAAELFVLASNESRGLNSAAALRRWGYDSVVQVDYNTLVEAGYVSRCDYATAGTKDSAEQAVSGED
Protein: Velvet domain-containing protein (Q4WPY1)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Velvet complex subunit B
- Secondary metabolism regulator laeA
- C2H2 type master regulator of conidiophore development brlA
- Conidiophore development regulator abaA
- Velvet domain-containing protein
Sequence:
MPLFPANPRGLSDLPSHRNGLLDSYSAVQGLQLTMLSNTSSDFELIIRQQPNRARVAGGKEKERKPVDPPPIVQLRVREEGSYLAHLYDANEDQPVPVPPATALAGTLVSSLHRLKDVDNNDGGFFVFGDLSVKIEGEFRLKFTLFEMRKDVVTYLKSIISDRFTVSPPKTFPGMQESTFLSRSFADQGVKLRIRKEPRTLSLKRPPRPEEYPQQPLPRSPDRSSMQMSGNAFTGYPAAGRDYAYYGTPVKRQRTSVDYGNRGIYDAEGRMRQVDAYPQTTAMYPNQPGTYQTPMMQGYPAGHTGVPDYAMPYGIPPSAQVAQMQDPAAHARSSQQATMQSLGMMNQPGTPTADSTAAMMPQGYPQPRTQQYQTSSTILPPLQRNRNFPQGTNGASARGYFDQASQGATPILPSQPMGSTEGDRYGAAPGQTTFEHPGSHNGTPR
Protein: Protein phosphatase 1F (EC 3.1.3.16) (Protein phosphatase, Mg2+/Mn2+-dependent, 1F) (A2BE49)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Activating signal cointegrator 1 complex subunit 2
- Crooked neck-like protein 1
- Ess-2-splicing factor homolog
- KAT8 regulatory NSL complex subunit 2
- Dgcr2 protein
- Proline-rich mitotic checkpoint control factor
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor SYF1
- Mediator of RNA polymerase II transcription subunit 15
Sequence:
MSGAEKGDVRTFLESFLQEFSKPLGTEDPLPVSSANRIISLQELKGESLDLGLRLLSARNAPSWLAAVMCNVAVTELLKDDLTPHYCPKDPEQQPEDEQGVVLLQSEPVLRLFINKLRAVGVAWQKQPPNPDAPSSRTHSCSVHAIRNTRRKMEDRHVILKEFNQLLGLQDGVGREYYAVFDGHGGVDAATYSATHLHIVLSQQGELKTDAATAFKNTFTQTDDMFKIKAKRERLRSGSTGVAVLLTSDLLTVSWLGDSQALLVRQGEPVTLMDPHKPEREDEKKRIEDLGGCIAFMGCWRVNGTYAVSRAIGDFDQKPYVSNEADSSSFHLTGDEDYVLLACDGFFDVIRPADVPALVLEALRESGGSGNDVAQSLVAQAKTAGSSDNITVLLVFLKEPQKLLAHDTVCRTEGRGAACAAAGV
Protein: CAP1-binding-protein (Q5AKU3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Involved in oxidative stress response and redox homeostasis. Required for hydrogen peroxide-induced oxidation and nuclear localization (activation) of CAP1. Functions probably in concert with GPX3, the actual CAP1 modifying enzyme.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23706023}.
Interaction partners:
- Glutathione peroxidase-like peroxiredoxin GPX3
Sequence:
MENLESGAQDALQSKDFLSYSTLLDIYLNDPTKYSNEEKEQLLGHILTILSENKQLTYEIGWDLPQLLILYVDSDYEFNGPIRDSPGVYKILKIFENLAINGNHKELFLKSCELLNDLELSQDEDIELLKRENFFEIKLYCVFELIDACLKKIHTLYPSRFLAMTVSSFNNLMFKLTKQHGSLGNYHFVMKRVYSFCRNYISPPLPTNAKEMPQEELDKIVKDEEYLQRRLLTGFLTQVIYLANINGTEGYSIEHFSWLQQQSKSKIKFVFERDGAFCDRFVELASSFDIDLLKCFQGFITDSHKLLIGIDYKNKNKSEDEIIELLFERVVVDYQKNVLTSIVDSDAKAIKDSIIGELILFTHSIAGKKNFAKPTMSIHDSLVMTLRLIIPQMVNPKFINAGNHDVVVFWVWFALYQQQIINSKNLQLEISYIPKVLLTTFFQCLLFIVIKSEGKPNFKYMLLTLLTKLLTLSPDTGYEFIKDSLNNCPYESVYPSLIGVYKQLLLNEKWDVNSIELEKLNISSSSSNTPPKLPPRNGIKRKHFSLTNESLNDLVDLINNSSKNAFVEDNSKIDPSKLSTIAAYLNLLVAIKKDPVIVENKEKLTTLISSIENKIKSVKKSSQNQFELNAAGMLEITIERFNE