wanglab/gogpt-training-data huggingface dataset:
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (M9NDF9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDDFGSTASDLEEATCPMQANATFSIDWRVTLLDHWLDLYLGYMNRLHMLLSLAGRLHLLSRHILGTLGQDPIFMGVLQGSLLMLFLFLMHLLRLWSCGYAVERPLNPTPDVAKELSCDFNFVSEQEKRAAQEAATEALLEVEEKKRRKRFTKKRNCVSAGPILIALRHQSKRPKHHRHAALPFEPVTPGEIILDTYLPPRELPLTIRLPQLAEPVKEEEVEYIELKSEPRGTLSTTDEIYPDSSDSSLYVSDEEQEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDEDAESDTLGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPSEGPIPEQPTPNSTNSSCPSHNTATIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPPSATPSSAPALASATPPSTCTPSFTQIAPSATAPATSTTCTTSAEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWLEQEEFV
Protein: RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) (RNA-binding motif protein, X chromosome retrogene) (RNA-binding motif protein, X chromosome retrogene-like) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] (Q4V898)
Organism: Rattus norvegicus (Rat)
Function: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.
Subcellular location: Nucleus {ECO:0000250}. Note=Component of ribonucleosomes (By similarity). Localizes in numerous small granules in the nucleus. {ECO:0000250}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein K
- Heterogeneous nuclear ribonucleoprotein C
- Heterogeneous nuclear ribonucleoproteins C1/C2-like
- Heterogeneous nuclear ribonucleoprotein A1
- Heterogeneous nuclear ribonucleoprotein A3
- Heterogeneous nuclear ribonucleoprotein U
- RNA binding motif protein, X-linked-like-1
- Regulator of nonsense transcripts 1
- RNA helicase
- Double-stranded RNA-specific adenosine deaminase
Sequence:
MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGLPPPPRSRGPPRGLRGGRGGSGGTRGPPSRGGHMDDGGYSMNFTLSSSRGPLPVKRGPPPRSGGPPPKRSAPSGPVRSSSGMGGRAPVSRGRDGYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYGRERDYSDHPSGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYTSSRSDLYSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRGGRSRY
Protein: cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1) (P51817)
Organism: Homo sapiens (Human)
Function: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.
Subcellular location: Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
Interaction partners:
- cAMP-dependent protein kinase type II-beta regulatory subunit
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- cAMP-dependent protein kinase type I-beta regulatory subunit
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- Amelogenin, X isoform
- Oligosaccharyltransferase complex subunit OSTC
- Amelogenin, Y isoform
- Variable charge X-linked protein 3
- Protocadherin 11 Y-linked
- Arylsulfatase F
Sequence:
MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF
Protein: U6 snRNA phosphodiesterase 1 (3'-5' RNA exonuclease USB1) (EC 4.6.1.-) (Mutated in Poikiloderma with Neutropenia protein 1) (O13915)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: 3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.d. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03040, ECO:0000269|PubMed:23022480}.
Interaction partners:
- LSM2-LSM8 complex subunit lsm8
- U4/U6 snRNA-associated-splicing factor prp24
- Pre-mRNA-processing factor 19
- LSM complex subunit lsm2
- Meiotically up-regulated gene 113 protein
- Uncharacterized protein C16C6.04
- Uncharacterized protein C56F8.02
- Uncharacterized protein C1494.08c
- Pre-mRNA-splicing factor cwf3
Sequence:
MSLVCYESSSSGEDDDETISDNPRMLKVPKLQESFHELYKKKPKTFDSPEFHEGRIRGQKHIEGLWFVQTYLEVDLSKKVKKGIREFLNSQSRFQSLLCSEHNVPRRLHLSISENYRINYSTKNQLVHKWEQYTNNLNYRTLKFRLGKMCLLFNDEKTRMFLAFECKFSDENYKDLISHASDCMKEFTNRNLREDFLLHISFASSLTNEDEYQNWVSQDRESHFFKTMNEIINTKIQKDQFSESFIVDSLKLSIGHLIFTFPFCK
Protein: Sonic hedgehog protein (SHHA) (EC 3.1.-.-) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) (VHH-1) [Cleaved into: Sonic hedgehog protein A N-product (Shh N-terminal processed signaling domains) (ShhNp) (Sonic hedgehog protein N-product) (ShhN)] (Q92008)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).
Subcellular location: [Sonic hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}.; SUBCELLULAR LOCATION: [Sonic hedgehog protein A N-product]: Cell membrane {ECO:0000250|UniProtKB:Q62226}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (By similarity). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides. {ECO:0000250|UniProtKB:Q62226}.
Interaction partners:
- Protein patched homolog 1
- Protein patched homolog 1
- Protein smoothened
- Hedgehog-interacting protein.
- Cell adhesion molecule-related/down-regulated by oncogenes
- GLI family zinc finger 2a.
- BOC cell adhesion-associated, oncogene-regulated.
- Fibroblast growth factor 8
- GLI family zinc finger 3.
- GLI family zinc finger 1
Sequence:
MRLLTRVLLVSLLTLSLVVSGLACGPGRGYGRRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNHWPGVKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSALVSLQDGGQKAVKDLNPGDKVLAADSAGNLVFSDFIMFTDRDSTTRRVFYVIETQEPVEKITLTAAHLLFVLDNSTEDLHTMTAAYASSVRAGQKVMVVDDSGQLKSVIVQRIYTEEQRGSFAPVTAHGTIVVDRILASCYAVIEDQGLAHLAFAPARLYYYVSSFLFPQNSSSRSNATLQQEGVHWYSRLLYQMGTWLLDSNMLHPLGMSVNSS
Protein: Leucine-rich repeat-containing protein 40 (Q9H9A6)
Organism: Homo sapiens (Human)
Interaction partners:
- Protein canopy homolog 3
- BTB/POZ domain-containing protein KCTD3
Sequence:
MSRLKRIAGQDLRAGFKAGGRDCGTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRIPT
Protein: Uncharacterized protein C19C7.01 (Q9USW8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized RNA-binding protein C23A1.09
- Protein mago nashi homolog
Sequence:
METNGSFSGARLVDGKWIIPESRRKDGSVRRERAVKPGYTAPEDIKRYRPGRGNFASLEKQMKKLQLSNDASTSKSIDRPPISELEKEKLERPLSNKKKEKNDHKAESLKHDYDSVGEKRISKDSVKHLDKTYSSIDSKKDFKYNFPKTQAPEWRRGAKPLSKTSEPSVYSEKMSKRENKKSINTVDKKTGYKEKE
Protein: RNA-binding protein L (Q0J9Y2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: RNA-binding protein that binds to a cis-localization element or zipcode, within the 5'-CDS of prolamine RNA. Binds strongly to glutelin and prolamin mRNAs, particularly to 3'-UTR and zipcode RNA. Recognizes and binds to glutelin zipcode RNA, which is required for proper mRNA localization to cisternal endoplasmic reticulum. Recognizes and binds to prolamin zipcode RNA, which is required for proper mRNA localization to the protein body endoplasmic reticulum that delimits the prolamine intracisternal inclusion granules. Required for the correct localization of glutelin and prolamine mRNA in endosperm cells during grain development. RBP-L and RBP-P form a quaternary complex with the membrane trafficking factors NSF and RAB5A. This quaternay complex carries glutelin mRNAs for active transport on endosomes to the cortical endoplasmic reticulum membrane, and enables endosome-mediated glutelin mRNA transport in endosperm cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:30659066}. Cytoplasm {ECO:0000269|PubMed:30659066}.
Interaction partners:
- Nuclear cap-binding protein subunit 2
- Nuclear cap-binding protein subunit 1
- U1 small nuclear ribonucleoprotein C
Sequence:
MQQPPSQPQPGMGGPPPPPQGAAGQPPQWGAIPPPMPPHQYGAPPPQQPPAMWGQPPPQAHYGQVPPPQPYYAAPPPQAMPAPAAADEVKTLWIGDLQPWMDESYIYNCFAATGEVQSVKLIRDKQSGQLQGYGFVEFTSRAAADRILQTYNGQMMPNVEMVFRLNWASAGEKRDDTPDYTIFVGDLAADVTDYLLQETFRVHYPSVKGAKVVTDKMTMRSKGYGFVKFGDPTEQARAMTEMNGMLCSSRPMRIGPAANKKTTGVQERVPNAQGAQSENDPNNTTIFVGGLDPNVTEDVLKQVFAPYGEVVHVKIPVGKRCGFVQYVNRPSAEQALAVLQGTLIGGQNVRLSWGRSLSNKQPQHDSNQWGAGAGAGGYYGGYGQGYEAYGGYAQPQDPNMYGYGAYAGYPNYQQQQVAQQQPPQQ
Protein: Tail tube terminator protein (TrP) (Gene product U) (gpU) (Minor tail protein U) (Tail sheath-stabilizing protein) (Tail-to-head joining protein) (THJP) (P03732)
Organism: Escherichia phage lambda (Bacteriophage lambda)
Function: Plays an essential role in tail assembly by capping the rapidly polymerizing tail once it has reached its requisite length and serving as the interaction surface for the completion protein.
Subcellular location: Virion. Host cytoplasm.
Interaction partners:
Sequence:
MKHTELRAAVLDALEKHDTGATFFDGRPAVFDEADFPAVAVYLTGAEYTGEELDSDTWQAELHIEVFLPAQVPDSELDAWMESRIYPVMSDIPALSDLITSMVASGYDYRRDDDAGLWSSADLTYVITYEM
Protein: SHF protein (Src homology 2 domain containing F, isoform CRA_b) (cDNA FLJ37072 fis, clone BRACE2015412, weakly similar to Shb=Src homology 2 protein) (Q8N9I8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATPEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQLVSRGHQPNRRREPAPAVQRGQLPGAQQ
Protein: Preprotein translocase subunit SCY1, chloroplastic (CpSecY) (Q38885)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in protein export. Probably interacts with other proteins to allow the translocation of proteins across the chloroplast thylakoid membranes. Required for normal greening during embryogenesis. Central subunit of the protein translocation channel SecYE. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug (By similarity).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:10207046, ECO:0000269|PubMed:12217076}; Multi-pass membrane protein {ECO:0000269|PubMed:10207046, ECO:0000269|PubMed:12217076}.
Interaction partners:
- Inner membrane protein ALBINO3
- AT2G34250 protein
- F9K20.24 protein
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- SecY protein transport family protein
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Large ribosomal subunit protein uL18y
- Protein transport protein Sec61 subunit beta
- Signal recognition particle subunit SRP54, chloroplastic
Sequence:
MITVSEVSSYSSSSSNFASLSRLNHKSSSRLRSSSLYKGSFFSVSTKTRRNTCKAKSWNLGLVINSRSSEASVFDPLGINPDETSGLSSIWESFVSLLSPSFESSSGNRRDKPSSGRGVAAAIEDSSIDFGDFFKGPLPGKFLKLLGFLALSRLGIYIPLGGVNREAFVGNLDQNSILSTLDTFSGGGIGRLGICSLGIVPFINAQIVFQLLAQVYPKLQDLQKKEGEAGRKKILQYTRYASVGFAIVQAIGQVFYLRPYVNDFSTEWVVSSVTLLTLGSVLTTYIGERISDLKLGNGTSLLIFTSIISYLPASFGRTTAEALQEGNYTGLGTIVVSFLLLVLGIVYVQEAERKIPLNYASRYTSKAGGLQKSAYLPFKVNSAGVMPIIFSTSSLALPATLARFTGISALKNVAFALTPGGSFYLPTNILLIAFFNYYYTFLQLDPDDVSEQLKRQGASIPLVRPGKSTALFIKTVLGRISVLGSAFLAVLAAGPAVVEQITHLTAFRGFAGTSVLILVGCATDTARKVQAEIISQKYKNIEFYELDKYDP
Protein: Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)] (P02753)
Organism: Homo sapiens (Human)
Function: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
Subcellular location: Secreted {ECO:0000269|PubMed:12237133, ECO:0000269|PubMed:2444024, ECO:0000269|PubMed:5541771}.
Interaction partners:
- Transthyretin
- Receptor for retinol uptake STRA6
- Retinol-binding protein 1
- Apolipoprotein A-I
- Adiponectin
- C-reactive protein
- Albumin
- Serum amyloid P-component
- Resistin
- Beta,beta-carotene 15,15'-dioxygenase
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
Protein: Sorting and assembly machinery component 50 homolog (Q8BGH2)
Organism: Mus musculus (Mouse)
Function: Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9Y512}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250|UniProtKB:Q6AXV4}. Mitochondrion {ECO:0000250|UniProtKB:Q9Y512}.
Interaction partners:
- Metaxin-2
- Metaxin-1
- Mitochondrial import receptor subunit TOM40 homolog
- Mitochondrial import receptor subunit TOM22 homolog
- Mitochondrial import receptor subunit TOM40B
- MICOS complex subunit Mic19
- MICOS complex subunit Mic60
- Metaxin
- DnaJ homolog subfamily C member 11
- Membrane-bound transcription factor site-2 protease
Sequence:
MGTVHARSLEPLPSSGTDFGALGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIICEIGEVFKAKNLIEVMRRSHEAREKLLRLGIFRQVDVLIDTCHGEDALPNGLDVTFEVTELRRLTGSYNTMVGNNEGSMVLGLKLPNLLGRAEKVTFQFSYGTKETSYGLSFFKPQPGNFERNFSVNLYKVTGQFPWSSLRETDRGVSAEYSFPLWKTSHTVKWEGVWRELGCLSRTASFAVRKESGHSLKSSLSHAMVIDSRNSSILPRRGALFKVNQELAGYTGGDVSFIKEDFELQLNKPLALDSVFSTSLWGGMLVPIGDKPSSIADRFYLGGPTSVRGFSMHSIGPQSEGDYLGGEAYWAGGLHLYTPLPFRPGQGGFGELFRTHFFLNAGNLCNLNYGEGPKAHIRKLAECIRWSYGAGVVLRLGNIARLELNYCIPMGVQGGDRICDGVQFGAGIRFL
Protein: Pathogenesis-related protein PR-4 (PpAz89) (P83343)
Organism: Prunus persica (Peach) (Amygdalus persica)
Function: May be involved in protecting plant tissues from pathogen infection.
Subcellular location: Secreted, cell wall {ECO:0000250|UniProtKB:P85494}.
Interaction partners:
Sequence:
QNINWDLRTASVFCATWDADKPLSWRSKYGWTAFCGPVGPTGQDSCGKCLLVTNTGTGAKVTVRIVDQCSNGGLDLDVNVFNQIDTNGQGNAQGHLIVNYDFVDCGD
Protein: E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (RING-H2 finger protein ATL55) (RING-type E3 ubiquitin transferase ATL55) (Q9LX93)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase that may be involved in positive regulation of programmed cell death (PCD) by facilitating degradation of negative regulators of PCD. May be involved in the early steps of the plant defense signaling pathway. Undergoes auto-ubiquitination.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18643987}; Single-pass membrane protein {ECO:0000269|PubMed:18643987}.
Interaction partners:
- Chromo domain-containing protein LHP1
- Putative E3 ubiquitin-protein ligase RING1a
- Protein EMBRYONIC FLOWER 1
- Putative E3 ubiquitin-protein ligase RING1b
- At1g50440
- Endonuclease or glycosyl hydrolase
- AAA-ATPase At3g28510
- Bromo-adjacent homology
- Histone-lysine N-methyltransferase EZA1
- Probable E3 ubiquitin-protein ligase ARI8
Sequence:
MAFNHRKMLLSCLQFKDLRFCFRQYPPPPPPPPPPRELSLLLPTSICVVGSIILFLFLVFFLYLHITQQRRISAASVTPGDTNQQEDEDETEERDFSDFHHVWQIPTVGLHRSAINSITVVGFKKGEGIIDGTECSVCLNEFEEDESLRLLPKCSHAFHLNCIDTWLLSHKNCPLCRAPVLLITEPPHQETETNHQPDSESSNDLRGRQDSSRSRRNHNIFLPRAQSDLANYCGSGRVENVRRSFSIGGSLSLCDGINNATRSGRQFYTSFSANLFSSSRRVRNEQPIPQNQMPSVTGNTS
Protein: ACP53C14C (Accessory gland protein 53C14c, isoform A) (Accessory gland protein 53C14c, isoform B) (GEO11116p1) (HDC06801) (IP20206p) (Q6IGA4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- ACP53C14A
- ACP53C14B
- Accessory gland protein Acp53Ea
- Lectin-29Ca
- Accessory gland protein Acp76A
- Accessory gland protein Acp63F
- Accessory gland-specific peptide 26Aa
- Accessory gland-specific peptide 95EF
- Accessory gland protein Acp36DE
- Accessory gland protein Acp29AB
Sequence:
MKSKQVFYIAFSLLLLGSLLPNEVESLRVDLNKLAECTESGLKVATTLLVRAIPCVKKLAKCADFRAIKTKDLDITALALLGYQYLQTVVNNQRCLLISLKEGYDAVSPHLDKLISGKCLPGLS
Protein: Origin recognition complex subunit 1 (Replication control protein 1) (Q13415)
Organism: Homo sapiens (Human)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular location: Nucleus.
Interaction partners:
- Origin recognition complex subunit 3
- Origin recognition complex subunit 5
- Origin recognition complex subunit 4
- Origin recognition complex subunit 6
- Cell division control protein 6 homolog
- DNA replication factor Cdt1
- Origin recognition complex subunit 2
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM2
Sequence:
MAHYPTRLKTRKTYSWVGRPLLDRKLHYQTYREMCVKTEGCSTEIHIQIGQFVLIEGDDDENPYVAKLLELFEDDSDPPPKKRARVQWFVRFCEVPACKRHLLGRKPGAQEIFWYDYPACDSNINAETIIGLVRVIPLAPKDVVPTNLKNEKTLFVKLSWNEKKFRPLSSELFAELNKPQESAAKCQKPVRAKSKSAESPSWTPAEHVAKRIESRHSASKSRQTPTHPLTPRARKRLELGNLGNPQMSQQTSCASLDSPGRIKRKVAFSEITSPSKRSQPDKLQTLSPALKAPEKTRETGLSYTEDDKKASPEHRIILRTRIAASKTIDIREERTLTPISGGQRSSVVPSVILKPENIKKRDAKEAKAQNEATSTPHRIRRKSSVLTMNRIRQQLRFLGNSKSDQEEKEILPAAEISDSSSDEEEASTPPLPRRAPRTVSRNLRSSLKSSLHTLTKVPKKSLKPRTPRCAAPQIRSRSLAAQEPASVLEEARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCMYISGVPGTGKTATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCTRGSPQETTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPERIMMNRVSSRLGLTRMCFQPYTYSQLQQILRSRLKHLKAFEDDAIQLVARKVAALSGDARRCLDICRRATEICEFSQQKPDSPGLVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVLYALKDE
Protein: Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I) (F8W2M8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (By similarity). Requires substrates with an unsubstituted N-terminus (By similarity).
Subcellular location: Lysosome {ECO:0000250|UniProtKB:O14773}.
Interaction partners:
- Battenin
- CLN6 transmembrane ER protein a.
- Uncharacterized protein.
- Palmitoyl-protein thioesterase 1
- Telomeric repeat-binding factor
- Cathepsin D
- Major facilitator superfamily domain-containing protein 8
- Protection of telomeres protein 1
- Napsin A aspartic peptidase
- TERF1
Sequence:
MRVAVFVLSFIWLVNGELLEADQDAVVPGDWTFLGRVGPLEEVELTFALKQQNVSKMEELLKLVSDPDSHQYGKYLSLDEVAALSRPSPLTEKVVENWLRSHGVMDCHTIITRDFLQCVMTVEVAEALLPGSKFHRFSKNTKTLLRSTSQYSVHEDVHQHLDFVGGVHRFPQKRKIVSKGWEGARQAILGYHLGVTPAVIRNRYNLTAKDVGTAANNSQAVAQFLEQYYHPADLAEFMSLFGGGFTHMSTVERVVGTQGGGKAGIEASLDVEYIMSSGANISTWVFTNPGRHESQEPFLQWMLLLSNMSAVPWVHTISYGDDEDSLSEAYMNRINIEFMKAGLRGISMLFASGDSGAGCRHLTKERNTFRPSFPASSPYVTTVGGTSFQNPFKLSYEVTDYISGGGFSNVFPMPDYQVDAVRAYLKSVQSLPPQTYFNTTGRAYPDLAALSDNYWVVSNRVPIPWVSGTSASTPVVGGILSLINDQRFLKGLPALGFINPRLYKMQGKGLYDVTVGCHLSCLDDKVEGKGFCASPSWDPVTGWGTPNYPVFLASLMD