wanglab/gogpt-training-data huggingface dataset:
Protein: Homeobox protein orthopedia (P56672)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in the development of the central nervous system.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Interaction partners:
- Protein Optix
Sequence:
MLNNLGANVLGPKDCDLPKAALTALHAGVNSFGQLPVGPNLADLGGGAGGGGSSGGVPVGGGVARLHISGGLCDNSNALNGGNGSSGNGNGNNNNGNGNNNNSMQQQDQKRHRTRFTPAQLNELERCFSKTHYPDIFMREEIAMRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRTPGALLPSHGLPPFGANITNIAMGDGLCGTGMFGGDRWSVGVNPMTAGFGQLNQSSPLSSSLNSGLNSGINMGSALGAGSYQHYGLNALGDSMMYQHSVGGVSCGPSGSPSATTPPNMNSCSSVTPPPLSAQPNSSQNELNGEPMPLHQQQQQQTHQHQQQQTHQHHPMAPPTPTQQQQQLPQSMQSPSDGANDTLHSIAALRRRASELNAIPSYLQMAPHNYEHYNSNSNSVY
Protein: Survival motor neuron-like protein (O97304)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Pre-mRNA-processing factor 6, putative
Sequence:
MDEFNETLEGLEEKIEEYEKQLALVRDEIKKYEKPEEENEQIKNLKKLEADMIEVINLTRDLIKYKKQNELENDENKELERSGEVAPDIHEHIKESNKFIGRTCSLNYENKMVYGLIENVVIHNNIEQLLIHIFETNDRIMIPPNYVQLNEVLNESALKENNQFQALYKKDGQWYDCIISKYKGDSFLITYIGYNNSEYVSTDQVRIKKKKKIKEIITPAGYKLPENLIIKEGDSLKVKMAKKKKRIALKKKQKDEIMDKEFSNKSKQWRSFHEKAISKSKHLLVSTKRVENIENKNNQSNFNIRRKFDYNDNEE
Protein: TLD domain-containing protein 2 (TBC/LysM-associated domain-containing protein 2) (A2ACG1)
Organism: Mus musculus (Mouse)
Interaction partners:
- Uncharacterized protein SPEM2
Sequence:
MEDTLSGEEGEEEEEEEPAPAPAPQDPVEPQLTEASQVLGASEIKQLSLHLPPRVTGHPWSLVFCTSRDGFSLRRLYRQMEGHSGPVLLLLRDQDGQMFGAFSSSAIRLSKGFYGTGETFLFSFSPQLKVFKWTGHNSFFVKGDLDSLMMGSGSGQFGLWLDGDLYHGGSYPCATFNNEVLARREQFCIKELEAWVLS
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q4WU06)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- Eukaryotic translation initiation factor 2 subunit alpha
- Serine/threonine-protein kinase TOR
- TORC1 growth control complex subunit Kog1, putative
- Target of rapamycin complex subunit LST8
- Protein kinase, putative
- Histidine biosynthesis trifunctional protein
- eIF-2-alpha kinase activator GCN1
- ABC-type ATPase Hef3-like, putative
- Translation elongation factor eEF-3, putative
- ATP phosphoribosyltransferase
Sequence:
MPHKQKKNPSNVHKNGSPRAERKQSTSNTIPLAQPGLATTNYREIHQNEAEALRSIYGDDFEEIEHRPSAWQQSADVAFKLHLRASSNPEVRVDLLVELPTTYPKTYPNLSLGNSENIRHRARLKIQDIIRNKPKELLGSEMIYELAVSIQDVLEDVAQAQAQDKDLPSLEEERMVQEAAANQRAELERQEELRKQEAATAEEERALQQLLEDKLRERTKARLSRRKSRSSGTGLSGSIDAVDQFPDAITFDPPLIINDTNEQPLAFSAVFGKTLLQSSPGKQTFTVRPVVSGSRSHAPLIVLKELSLDGNGTAPICYRERMRASEDKLEALKRLRHPNLVDFIGFKISRPLDSIDAQDSTWRVYLLLEYANKGSLSEFLDIVGSVSVEIIRAWMIQLLEALEFYHRSGFVHGDIHCGRILLFRNPQGGTIVKLQGSIEDALPDTENSKRSLTISKSPFWMPPELTQESTPPTMKTDVWDMGIVFLQMAFGKDVLQRYTSANALMGTLGLSAPLQDLLHEFFRPDPKKRPTAFQLQPFEFFRVDTPLIARTSTSNSVSLPRRPRLDSTGGLPAFSRYNQDFDEAGRLGKGGFGQVVKARNKLDGRFYAIKKISQRSASALKDTLSEIMLLSRLNHPYVVRYFTAWLEEEYDQIDEEAISSTEGDPFASRDADGFEYSTGGLDFISSSGYPKIEFASDSDDEHDASLSQGGGTESYDAYREDSAAGTELSRVRSGSQGRAHLTTLYIQMEYCEKHTLRDLIKNGLYDDIDRSWRLFRQILDGLSHIHSHGIIHRDLKPDNIFIDVASNPRIGDFGLATSGQFTTAVRSSTTADFEGNLTRSLGTTYYVAPEMKSGFAGHYNEKVDMYSLGIIFFEMCHPLPTGMERDQTLRAIREEHHTLPPTFHYSEKAVQGNIIESLLSHDPKERPSASELLQSGKIPLQVEEETFRRAIVHLLSDPNAPDYKKILSAIFSQSPKKYEDIAWDVDSRAAPAANELLVQSLVKERLTAIFRRHGAVETTRQMLFPRSQHYRSGAVRLLDASGNQLQLPFDLTLPNARSISRQDPSLEKTFAFGTVYREMPHGSEPRTHKEVDFDIVSHNTLDLALKEAEVIKVLDEIIEEFPPLRSSPMSFLINHSDLLQLIMEFCRITPSQVPLVKEIISKLNFGKWTMQKIRSELRSPAIGVASTSLDDLARFDFRDTPKQAQNRLRSVMEGTEFAERLSPIFARINILVTYLQGFDVKRKVYVNPLGSLNDKFFRGSILFQCVFDTKRRDVFAAGGRYDRLVQEFRPKGRASCSQTHAVGFNLSWDRLSSAMLEYLKSTTKATTKHAESDAGAFWKTRRCDVLVASFDATVLRTTGVKLVQHLWASDISAELAVDASSLEELLSEYKEHNHSWIVIAKQDSKERGFKVRCLAPREELDIRSSELIPWLRNEIRARNQREGAPDLRQSRLPSQSDAIAGANERSSDVRILVSQHRSKKTNRRNIVESALLRSREVVEKAINGPIAAIDTRDDLLEAIRDTRLSDPESWRSVIQSAPLTERKYLSQVHELLLDLSNECRANDGPDSVSNAFIYNYRTGSCLYYDLGRGSEK
Protein: DiSHevelled related (Q18239)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Protein mom-5
- Vang-like protein
- LIM zinc-binding domain-containing protein
- Frizzled-4
- Frizzled-2
- Glycogen synthase kinase-3
- Axin-like protein pry-1
- Frizzled-4
- FH2 domain-containing protein
- DiSHevelled related
Sequence:
MTDSPSPIDSSFDASDVATPCTVIAAKISLRNRNGLEEDQENLDSFDAFTETHETQESKNIAHGEHEEDVSNIYVDDFSKEFGDTVSSVMEPLPKPLTFARTITKVYCHLDDQEHPYMVEVHVPPDCITLRDVKRKLMRTNFKYYCIALDPDTGLEVKAEVRDDSRRLYPLKNGRFELYLLTVEGSVHSDTSSGRHRRKQDGSSKGSSGSREYLRAAHHYDNPTPFSDDESQASSLPTYVKKAHAYNRKHAPQAYERHLPHMKHNNRHNHHRQNHYEESTFDVTTESDDHYRDGVTYYDEDEDDSRSINTDLTSVSQVHLKQKWRQQQKEMRNKWKRMPSISTASSSFSSITESSMGLEVITVRLNLETIPLGMTPSGHTNARGDAGLYVGDIQDRGAVALDGRIDIGDMIVGINEISLGNYSNKEAVQLLREAVQRQYLTLTIAKTGDPKQNAFPRNPRAEPIRPIDPNEWVKHATNAMKAMPSISEESSSTPIPDDWPTNSSASGTPFGGPPPANCLNVMTDKKYVVEVMAAPGSGLDIKDRYWFKIPIPMSFLGTDLVEWLVKHVQGLETKKKAREFAEEMLKLGYIRPGVGKQSFTKECYYVMGDECADYTQLRGPDGGYKYPQSHASSASGHSSNNLIFPPSMYPPQPPTAGAVHHRNSVILPSSMTGGYASLPASPFPHGKASVNDCRRTRDDQRSQASGSSRGSSRRYVELPRKPASLSSGSGLAVDLDRVASRSSFRAAMNGSHPQFNIDN
Protein: Melanoregulin (Dilute suppressor protein homolog) (Q8N565)
Organism: Homo sapiens (Human)
Function: Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells. Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q6NVG5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NVG5}. Melanosome membrane {ECO:0000250|UniProtKB:Q6NVG5}; Lipid-anchor {ECO:0000250|UniProtKB:Q6NVG5}. Lysosome membrane {ECO:0000250|UniProtKB:Q6NVG5}; Lipid-anchor {ECO:0000250|UniProtKB:Q6NVG5}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6NVG5}. Note=Localizes to the inner segment and basal outer segment of rods in the retina. {ECO:0000250|UniProtKB:Q6NVG5}.
Interaction partners:
- Unconventional myosin-Va
- Ras-related protein Rab-27A
- Melanophilin
- Ras-related protein Rab-27B
Sequence:
MGLRDWLRTVCCCCGCECLEERALPEKEPLVSDNNPYSSFGATLVRDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEEWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNIFPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYPKKPGVPCLADGQKELHYLPFPSP
Protein: Coatomer subunit zeta (Q8IQP1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU366053}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|RuleBase:RU366053}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|RuleBase:RU366053}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|RuleBase:RU366053}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000256|RuleBase:RU366053}; Peripheral membrane protein {ECO:0000256|RuleBase:RU366053}; Cytoplasmic side {ECO:0000256|RuleBase:RU366053}.
Interaction partners:
Sequence:
MDGFMMDIIKGMCIMDNDGNRILAKYYDKNILSTLKEQKAFEKNLFNKTHRSNTEIIMLDGLTCVYKSNVDLFFYVMGNAYENELILLSVLNCLYDSISLILKKNVEKRLVLENLEIIMLAFDEICDGGIILDADPSSVVKRVDLRNDDIPIAEQTVAQVTNTLNGLFW
Protein: Fms related receptor tyrosine kinase 4 (Soluble VEGFR3 variant 2) (B5A927)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQKIPSSASSGSKDPSWRPRQETSW
Protein: 5'-deoxynucleotidase (EC 3.1.3.89) (Deoxynucleoside-5'-monophosphatase) (5'-dNMPase) (Protein dmp) (Q38167)
Organism: Escherichia phage T5 (Enterobacteria phage T5)
Function: Following host DNA degradation, is responsible for the degradation of 5'-dNMP's to deoxynucleosides that can be further excreted. Active on deoxynucleoside 5'-monophosphates but not active as a phosphatase on ribonucleotides, deoxynucleoside 5'-triphosphates, deoxynucleoside 3'-monophosphates, or deoxyoligonucleotides.
Interaction partners:
Sequence:
MNQVKTNITRNFPHISRVMIWDLDGTIINSFHRVAPCFDSEGNLDLNKYKNEACKHDLIMQDTLLPLVTYMRQCMNDANTLNIICTARLMSKSDYYYLRKQGLRGRGDSNIRVFSRDTLHKYFEADKVSEIYHSKDAVYKSYYFGLFKQLYPNADFTMIDDHKGVLSAAASYGFKTLDAQAVNDILSIGVTLIGETFIDESLEDDNDYQFLADRLQLCWEGMTEEERAEYSCSPQQYIEKLKVA
Protein: Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) (Q6GQN0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of tubulin polyglutamylases between the basal body and the cilium.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Localizes mainly to the cilium basal body and in primary cilia. {ECO:0000250}.
Interaction partners:
- Tubulin polyglutamylase ttll6
- Tectonic family member 1
- Tubulin tyrosine ligase-like family, member 1.
- Serine/threonine-protein kinase PLK
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
- Transmembrane protein 82
- Transmembrane protein 216
- Abelson helper integration site 1.
- ADP-ribosylation factor-like protein 13B
- Centrosome and spindle pole-associated protein 1a.
Sequence:
MSVKRGIGDSAFLKKKIPQNPKYQHVKTRLDTGSSLTKYMERLEEARKNYRYRKDELFKRLKVTTFAQLVIQVASVSDQNDNIKDEMAGLEDDVSIFSASPGLDCLSDQTNGSPQPNLPPPQTINIDESGDNGFSPRSTLQSVISGVGELDLDKNGQKTIRLSPVSTSNTTECPYPDCPYLLLDVRDRELYDQCHIVSAYSYPIATLSRTMNPYTKEVLDYKNASGKIIIVYDEDERIASQAATTMCERGFENLFMLSGGLKVVAQKFPEGMTTGSVPISCLPSPTGPAGRKRSAQHQTSQLAEKKWRFTAEDLDKIQHYLEEVFIPSETSSRLSSRMSTSSARSKASTVGSSRQGSSIAGSESARSRSSRPWK
Protein: Uncharacterized protein (Q57YP1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRHSVKCLAGIMFTTRSPLRSGYKYFEDMFPKHEPAPRYNTYEEQQRGATVKSLEPRRQLSESEKLHHLHDWKKEQDGLTPPPEFGWPEEWGPEPGEEGHSEWYKKNRVYMSYEEKAKYDFRLGVPVEKNSMRHQEMPYHRRMKAAYHNLQEDKPQWFDPRQRKYWAQYSYEDQRDSVAKSRDDYLREWLDKPDVTQENVAKKIGDYNGTAKHQSVKPVQRRPEWELAPLQGKKSD
Protein: Ribonucleoside-diphosphate reductase 1 subunit beta (EC 1.17.4.1) (Protein B2) (Protein R2) (Ribonucleotide reductase 1) (P69924)
Organism: Escherichia coli (strain K12)
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.
Interaction partners:
- Ribonucleoside-diphosphate reductase 1 subunit alpha
- Ribonucleoside-diphosphate reductase 2 subunit alpha
- Uncharacterized ferredoxin-like protein YfaE
- Protein NrdI
- Ribonucleoside-diphosphate reductase 2 subunit beta
- Nucleoside diphosphate kinase
- Cytidylate kinase
- Anaerobic ribonucleoside-triphosphate reductase
- Adenylate kinase
- Thymidylate kinase
Sequence:
MAYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSNFQL
Protein: Histone gene-specific epigenetic repressor in late S phase, isoform D (Histone gene-specific epigenetic repressor in late S phase, isoform F) (Histone gene-specific epigenetic repressor in late S phase, isoform G) (Q2MGL2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRLKETTKKSTPSATTSAHSHKTVPPSGGLLSTLHISPSLHQLPLSVQLQHQLHHQQQQQQQQPLQHPLPHQPHQLQHLLHLQHQQQQQQQHQQRCSSVGSTSSSGTCETDRSYQSAGSCSSALSPAGGIGGIGGIMPGLAGATGDALGPAGAVAGSPGDEASAAAALAANIAESFTFLQQHAAHHFRDILYAAHMLGRGYYQPAGPLISPHVIAAPPPPAQVKKLQEEDGPVSAAGSPTQLQQQQAAAEAAAAAADQAAAQSQSQSQGQSHGHAHSHAHNPQQAQHPPQPQPYPAGAVAAAAAAAAAHQGVPYSRSMHAAQMHYSTGYPPNYYAPYPGEVMCYSPPTYPPYFSSKVYQPSHPAHPAAHPQGPPPPGAYRRYPYYQHAGPPPPHELYEQQPPPPPVSSGSVSGPAQQQPPTSSPASVGAAGAGTAGAPSGSQLVPAHQQQHQQQHLEHYPGPPSYYAGYSPGGGASAGQCYTRGLQGPYMEYPPQCPCPMPQSCPKNVHTGPHIGSNIISNIDQSSSCSSSMLLSATSNSNIGGGSSSSSSSSSSTTLPACSSATTTTTASALTTSRGPVKNVTPNNSNSSGHTSTNSCRSSNNSNNSSNSSCQTIEMTSWATAATNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEAHVMPPPTPPESYCASDEKLLDDQEQEAELELRLRLGLGLEKSHGGQQHIEAYDLTCSTPPPVTVPQAAAVPRKARIGKSMAREMVYAAQQQLLPEKQLKQPKEAAAKLEAEPEMPFVLKAEIKAETKIKIEHDGEAQASTHISQLPDLKPTIKTEPEQELEQEAASVPSVAKTEPQPEVEVEREQQEPPVDEEQQPTPGGSKQRFNLLALSSGNKKTKTNNSYKSLIKQAEPKSYLCPGRRFIRRHGRAPAKYVKRRQMILTQRQQQRMRLQRREQQQQRRQQREAAAEVVAGAVVTPSLAGNPIEQAGSEVSIVKDQAPNSSATPSASPKRARPRKQEIAALHLLEGLDTTLSRGYFSDPELNHSSRKQAPTAVGGLYAASSPLTTATDHRGKQTTAEKRSKSETKKPPSGESSESGLPCKKPRKEPAGKVKGKGKKTTAGAAATTIASTAETQTEAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAKVAGTATSTSTASQQQNQQHSDEQHQFLVPSQPATASATAALAATPPPSRQGQATHTKRTRSRCKFGNRKRQRHRPGGVSYELDVTQPPATKANVVPKWNNGWMWAGKAFQGAVFLNSDDPLVLRTCYPAMRHVEGDIIRIRDCVLLKANEDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVEDKCYVLTFSEYCRYRRRLRAAEEDVEDVSIVPRRPSIATAPGFPVRTVPEHTNPELVMFCRRAYEFRTRRLLKLPHKNGLVCSSS
Protein: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48) (Q8R5A3)
Organism: Mus musculus (Mouse)
Function: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15642358}; Peripheral membrane protein {ECO:0000269|PubMed:15642358}. Cell projection, lamellipodium {ECO:0000269|PubMed:15642358}. Cell junction, focal adhesion {ECO:0000269|PubMed:15642358}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15642358}. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases.
Interaction partners:
- Talin-1
- Ras-related protein Rap-1A
- Vasodilator-stimulated phosphoprotein
- Ena/VASP-like protein
- Profilin-4
- Src kinase-associated phosphoprotein 1
- Talin-2
- Ras-related protein Rap-1b
- Tyrosine-protein phosphatase non-receptor type 6
- Profilin-1
Sequence:
MGESNEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPREEFNYTVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESSQNQDRFALLRASDGQGTASGGYGASAAAIDVSHHEEALPPPPVEPMLDLLPPPPPPPPPELLSKEEEEAKAKADKIKLALEKLKEAKVKKLVVKVHMDDSSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERVFEDHENVVEVLSDWTRDTENKVLFLEKEERYAVFKNPQNFYLDNKGKKENKETNEKMNAKNKEYLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGIQCKMKYKAPTDHCFVLKHPQIQKESQYIKYLCCDDARTLSQWVMGIRIAKYGKTLYDNYQRAVARAGLASRWTNLGTVGTPMPAQPSTVSSGLKTGTSQPNGQMPQAIPSAGPPLQEAQTQIETTKDEKQGLGNHSPGATRENHRPKSSLPPPPPPVRRSSDTCGSPALPSKVKGPGTCTFPHPPENFLPPPPPPPPEEDNSGLLPPPPPPPYLEEPPDFVPPPPPPAAVEDSALPPPPPPPPCLSQEITKSSPLPPKKPLVPPKRQENQGLPGAPGNSEQDFMSDLMKALQKKRGNIP
Protein: Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) (Q8TBE0)
Organism: Homo sapiens (Human)
Function: Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.
Subcellular location: Nucleus {ECO:0000269|PubMed:19666599}. Chromosome {ECO:0000269|PubMed:19666599}. Note=Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27' (H3K27me3).
Interaction partners:
- Histone-lysine N-methyltransferase SUV39H1
- NAD-dependent protein deacetylase sirtuin-1
- NAD-dependent protein deacetylase sirtuin-2
- Ribosomal RNA-processing protein 8
- Zinc finger protein 282
- Histone deacetylase 1
- Mesoderm induction early response protein 3
- Ataxin-7-like protein 3
- Bromodomain adjacent to zinc finger domain protein 2A
- Chromobox protein homolog 3
Sequence:
MTHTRRKSLPMLSSGLTGRREPLQMEDSNMEQGVEGVEPGMPESPGHLTGRRKNYPLRKRPLVPEKPKACKVLLTRLENVAGPRSADEADELPPDLPKPPSPAPSSEDPGLAQPRKRRLASLNAEALNNLLLEREDTSSLAGTRRSRAGDPHRSRDRDRATGGWSSSKKRPRLGDLGGGSRDLSPEPAPDEGPRRDGDPAPKRLASLNAAAFLKLSQERELPLRLPRAHAEVDGRSTEPPAPKAPRPKWPKVNGKNYPKAWQGASSGEAAGPPGWQGCPDEPWPSATPCGPSVQPSHQPLSKALESPLGLRPHLPLLMGGQAALKPEPGRPGEESPAPKQELHQPSFPTPQLSPLPMPGNPADYNGLCVGPELTALGSFYLYCGQEGLQCGGYSPCPMLPEGKLSPVAAPHEEGLLLAPSSVPSGTPFQHPPWGSSRYCSSEDTGVNGYSICGVLPLSVTHAGTTCGGCPYKMPFAAEGCRSLGQLEFPLPEAGHPASPAHPLLGCPVPSVPPAAEPVPHLQTPTSEPQTVARACPQSAKPPSGSKSGLRTGSSCRHTARSKAARRPSHPKQPRVQRPRPRRRRRRRTNGWVPVGAACEKAVYVLDEPEPAIRKSYQAVERHGETIRVRDTVLLKSGPRKTSTPYVAKISALWENPESGELMMSLLWYYRPEHLQGGRSPSMHEPLQNEVFASRHQDQNSVACIEEKCYVLTFAEYCRFCAMAKRRGEGLPSRKTALVPPSADYSTPPHRTVPEDTDPELVFLCRHVYDFRHGRILKNPQ
Protein: Uncharacterized protein C1782.03 (Q9P7H6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- U4/U6.U5 tri-snRNP-associated protein snu66
- Pre-mRNA-splicing factor 38
- Pre-mRNA-splicing factor dre4
- U4/U6.U5 small nuclear ribonucleoprotein component snu23
- U2 snRNP component prp10
- Pre-mRNA-splicing factor spp42
- Pre-mRNA-splicing factor cwf26
- U2 small nuclear ribonucleoprotein A'
- Splicing factor 3B subunit 6-like protein
- Pre-mRNA-processing factor 31
Sequence:
MPIDTPLIPHKPISRYRSGRLEGLESESSSESDYEEVSDSHDQENSISSSRHVITPVFEKEGISETKTSSNFQNINPVQTIDNSASEYETDASSAEGGSNSAASSSEEEDSSDSEYEMELRRRTLLLPPKFTSKVIKNRAKANEEDTEVLKKVTSQKILEETIKRELLLKETKNNNELLNDIDDTDGIDPQSEYELWKLRHLLRKKRDKEKSLELEREKMAIEERRLMNSEEREAQDLKDAEASRRGKKKSSMQFLQKYYHKGAFYQNEDIVSKRDYSEATEGEVLNKDLLPKPMQIRGDLFAKAGQTRWTHLANEDTTKEGSAWYDPKNPILQKNLHRLGGLHSDSPLSKRKRT
Protein: (2E,6E)-farnesyl diphosphate synthase (E,E-FPP synthase) (FPP synthase) (EC 2.5.1.10) (P9WKH1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). May be used for squalene and possibly sterol biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15060088}.
Interaction partners:
- Phytoene synthase
- 
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
- Isopentenyl-diphosphate Delta-isomerase
- Nonaprenyl diphosphate synthase
- Dimethylallyltranstransferase
- 
- Geranylgeranyl diphosphate synthase
- Decaprenyl diphosphate synthase
Sequence:
MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVGAALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDLAHYIVDRQA
Protein: TRPV4 (Transient receptor potential cation channel subfamily V member 4) (B2KN54)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MADPSEGPHTGPGEVAETPGDESGTPGSEAFPLSSLANLFEGEDGSPSPSPADTGRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRKKVIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTTDLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNSDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEIITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCSEDHTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKSENYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDNMGNPSCDGHQQSYPPKWRTDDAPL
Protein: Lymphotoxin alpha (TNF superfamily, member 1) (Lymphotoxin-alpha) (Q4W897)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Novel immune-type receptor 2b
- Interleukin
- Novel immune-type receptor 4a.
Sequence:
MTGQSNPRFRLLIGWCCLMSSALLMMTVYLATSSNKQSETNTTTSEHHSSAGPQEKRVQFSELQALNVIDYIRLLKDKKKIWICTQPCKSKRLKLNNSSVEIASTGLYHIHAQVGFKRHESTQETKKTPQKNTINLIKNKGLSAQKKLSEVISFEPGTLRLIRLVKLKEGDSISLDINYQNQSMSLLEDEYHTYWEIILLNEI
Protein: 2,7-anhydro-N-acetylneuraminate hydratase (EC 4.2.1.-) (EcNanOx) (P39353)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Sialic acid transporter NanX
- N-acetylneuraminate anomerase NanQ
- N-acetylneuraminate epimerase
- Sialic acid transporter NanT
- N-acetylneuraminate lyase
- Putative N-acetylmannosamine-6-phosphate 2-epimerase
Sequence:
MINYGVVGVGYFGAELARFMNMHDNAKITCVYDPENGENIARELQCINMSSLDALVSSKLVDCVIVATPNYLHKEPVIKAAKNKKHVFCEKPIALSYEDCVDMVKACKEAGVTFMAGHIMNFFNGVQYARKLIKEGVIGEILSCHTKRNGWENKQERLSWKKMKEQSGGHLYHHIHELDCVQHLLGEIPETVTMIGGNLAHSGPGFGNEDDMLFMTLEFPSGKLATLEWGSAFNWPEHYVIINGTKGSIKIDMQETAGSLRIGGQTKHFLVHETQEEDDDRRKGNMTSEMDGAIAYGHPGKKTPLWLASLIRKETLFLHNILCGAKPEEDYIDLLNGEAAMSAIATADAATLSRSQDRKVKISEIIKHTSVM
Protein: tRNA/rRNA methyltransferase SpoU type domain-containing protein (Q57TV7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein uL29m
- 50S ribosomal protein L13, putative
- 50S ribosomal protein L17, putative
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL3m
- Ribosomal protein L11, putative
- KOW domain-containing protein
- Acyl carrier protein
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
Sequence:
MNTVKVLLRKRVVRAGAFEDTALALTNAHSAGAEARGRPIVLQSLDEVAQVTPTISFSGRQLWNSTKLLRENGNVRRSHGACVVGGASAIRRVWRDYKIRPNVVYVPDTEPTVASWCLEDELPTCIVRCSPVEINRGLLSAELADGHAAEFPIPASPSVETFLGEGKPSRLASMLVLVGLRIPSNVGTLIRAAVEMGFESVLLINCLDPFGEKALRASEGTVFSPQFKIFEPGSDPVSALNSIAVEHNLLPLLALPSQKAETAFEVAKNLHKINAMRRSQEAEGDAAASHNHIGPLLILGSEAKGLRDLAGEWSVPRKFVSVPLPNSTVESLNVSVAGSILIHAFRPAAEKHFVELEESARPRTLGDGPLLLR
Protein: Olfactory receptor 1L3 (Olfactory receptor 9-D) (OR9-D) (Olfactory receptor OR9-28) (Q8NH93)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MGMSNLTRLSEFILLGLSSRSEDQRPLFALFLIIYLVTLMGNLLIILAIHSDPRLQNPMYFFLSILSFADICYTTVIVPKMLVNFLSEKKTISYAECLAQMYFFLVFGNIDSYLLAAMAINRCVAICNPFHYVTVMNRRCCVLLLAFPITFSYFHSLLHVLLVNRLTFCTSNVIHHFFCDVNPVLKLSCSSTFVNEIVAMTEGLASVMAPFVCIIISYLRILIAVLKIPSAAGKHKAFSTCSSHLTVVILFYGSISYVYLQPLSSYTVKDRIATINYTVLTSVLNPFIYSLRNKDMKRGLQKLINKIKSQMSRFSTKTNKICGP