wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) (Q80UE6)
Organism: Mus musculus (Mouse)
Function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition.
Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:11498583}. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct (PubMed:11498583). WNK4 is part of the tight junction complex (PubMed:11498583). {ECO:0000269|PubMed:11498583}.
Interaction partners:
- Kelch-like protein 3
- ATP-sensitive inward rectifier potassium channel 1
- Solute carrier family 12 member 3
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Kelch-like protein 2
- STE20/SPS1-related proline-alanine-rich protein kinase
- Transient receptor potential cation channel subfamily V member 5
- Epithelial sodium channel subunit alpha
- Cullin-3
- Epithelial sodium channel subunit gamma
Sequence:
MLAPRNTETGVPMSQTEADLALRPSPALTSTGPTRLGPPPRRVRRFSGKAEPRPRSSRPSRRSSVDLGLLSSWSQPASLLPEPPDPPDSAGPTRSPPSSSKEPPEGTWMGAAPVKAVDSACPELTGSSGGPGSREPPRVPDAAARERRREQEEKEDTETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGTKPNSFYKVKMPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEVLPPDSGPPPATVSLAPGPPSAFPPEPEEPEADQHQSFLFRHASYSSTTSDCETDGYLSSSGFLDASDPALQPPGGLPSSPAESHLCLPSGFALSIPRSGPGSDFSPGDSYASDAASGLSDMGEGGQMRKNPVKTLRRRPRSRLRVTSVSDQSDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLSRIREIIQRVETLLKRDAGPPEAAEDALSPQEEPAALPALPGPPNAEPQRSISPEQRSWAAFSTSPSSPGTPLSPGAPFSPGTPPVFPCPIFPITSPSCYPCPFSQVSSNPYPQAPSSLLPLSSSASQVPLPSSSLPISAPLPFSPSYPQDPLSPTSLPVCPSPPSLPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPGPLPSLPLSLASCDQESLSAQTAETENEASRNPAQPLLGDARLAPISEEGKPQLVGRFQVTSSKEPAEPPLQPASPTLSRSLKLPSPPLTSESSDTEDSAAGGPETREALAESDRAAEGLGVAVDDEKDEGKEPLLGGSSPILSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQNLRQKHLSEVEALQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSCRQRRLSKGSFPTSRRNSLQRSDLPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDIGRM
Protein: Putative transcription factor YjjQ (P0ADD7)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Transcriptional activator protein BglJ
- HTH-type transcriptional regulator LeuO
Sequence:
MLPGCCKNGIVISKIPVMQAGLKEVMRTHFPEYEIISSASAEDLTLLQLRRSGLVIADLAGESEDPRSVCEHYYSLISQYREIHWVFMVSRSWYSQAVELLMCPTATLLSDVEPIENLVKTVRSGNTHAERISAMLTSPAMTETHDFSYRSVILTLSERKVLRLLGKGWGINQIASLLKKSNKTISAQKNSAMRRLAIHSNAEMYAWINSAQGARELNLPSVYGDAAEWNTAELRREMSHS
Protein: High-affinity branched-chain amino acid transport system permease protein LivM (LIV-I protein M) (P22729)
Organism: Escherichia coli (strain K12)
Function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
- Leucine-specific-binding protein
- High-affinity branched-chain amino acid transport system permease protein LivH
- High-affinity branched-chain amino acid transport ATP-binding protein LivG
- Leu/Ile/Val-binding protein
- High-affinity branched-chain amino acid transport ATP-binding protein LivF
- Lipopolysaccharide export system ATP-binding protein LptB
- Glutamate/aspartate import ATP-binding protein GltL
- Glutamine transport ATP-binding protein GlnQ
- L-cystine transport system ATP-binding protein TcyN
- Ribose import ATP-binding protein RbsA
Sequence:
MKPMHIAMALLSAAMFFVLAGVFMGVQLELDGTKLVVDTASDVRWQWVFIGTAVVFFFQLLRPAFQKGLKSVSGPKFILPAIDGSTVKQKLFLVALLVLAVAWPFMVSRGTVDIATLTMIYIILGLGLNVVVGLSGLLVLGYGGFYAIGAYTFALLNHYYGLGFWTCLPIAGLMAAAAGFLLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTLFGLEFSRTAREGGWDTFSNFFGLKYDPSDRVIFLYLVALLLVVLSLFVINRLLRMPLGRAWEALREDEIACRSLGLSPRRIKLTAFTISAAFAGFAGTLFAARQGFVSPESFTFAESAFVLAIVVLGGMGSQFAVILAAILLVVSRELMRDFNEYSMLMLGGLMVLMMIWRPQGLLPMTRPQLKLKNGAAKGEQA
Protein: Ectodermal-neural cortex 1 (Q6DKY8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Cullin-3
- Kelch-like protein 25
- Kelch-like protein 41
- Kelch repeat and BTB domain-containing protein 8
- Kelch-like family member 40
- E3 ubiquitin-protein ligase RBX1
- Kelch-like 9
- Kelch-like family member 9
- Kelch-like protein 2
- Kelch-like protein 7
Sequence:
MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAMNWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEQYDPTTNKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS
Protein: Desmin (P31001)
Organism: Mus musculus (Mouse)
Function: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (By similarity). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin.
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:26343497, ECO:0000269|PubMed:26787680, ECO:0000269|PubMed:28469177}. Cytoplasm {ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26787680}. Cell membrane, sarcolemma {ECO:0000269|PubMed:25394388}. Nucleus {ECO:0000269|PubMed:26787680}. Cell tip {ECO:0000269|PubMed:35959657}. Nucleus envelope {ECO:0000269|PubMed:35959657}. Note=Localizes in the intercalated disks which occur at the Z line of cardiomyocytes (By similarity). Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes (PubMed:26787680). PKP2 is required for correct anchoring of DES at the cell tip and nuclear envelope (PubMed:35959657). {ECO:0000250|UniProtKB:P17661, ECO:0000269|PubMed:26787680, ECO:0000269|PubMed:35959657}.
Interaction partners:
- Vimentin
- Telethonin
- Myosin-binding protein C, fast-type
- Tropomyosin beta chain
Sequence:
MSQAYSSSQRVSSYRRTFGGAPGFSLGSPLSSPVFPRAGFGTKGSSSSMTSRVYQVSRTSGGAGGLGSLRSSRLGTTRAPSYGAGELLDFSLADAVNQEFLATRTNEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREPTRVAELYEEEMRELRRQVEVLTNQRARVDVERDNLIDDLQRLKAKLQEEIQLREEAENNLAAFRADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEANGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRINLPIQTFSALNFRETSPEQRGSEVHTKKTVMIKTIETRDGEVVSEATQQQHEVL
Protein: Iron-sulfur cluster carrier protein (P50863)
Organism: Bacillus subtilis (strain 168)
Function: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Interaction partners:
- Na
- Tyrosine-protein kinase YwqD
- Na
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- Sodium, potassium, lithium and rubidium/H
- Na
- Uncharacterized ABC transporter ATP-binding protein YhcG
Sequence:
MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVKVALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNMDNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRPTIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVLDLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMAYYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIGEIYQDIAKKIDAKMSVQV
Protein: Synaptic Ras GTPase-activating protein 1b (E7F1U4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Patched domain-containing protein 1
- SH3 and multiple ankyrin repeat domains 3a.
- Patched domain-containing protein 1
- IQ motif and Sec7 domain ArfGEF 2b
Sequence:
MSYVPFQDARYAVPPSYRPQPSFAAAPSYEQADWNPRLGVISGNQLYMLDQEEVHPLLMRERRSESHRNKLLRRTVSVPVEARHHPEMDAARLRRKSIATGKQPSMEIPPTAPPQPFRQSVSNPPFRPRSLSPSLSLSLPFAPSPLSPSLSPSHLQSQKRISTPPLPRSLPLSPSVSLTLPPSVPLSHWAAGEWKVVGSNPGTGSSVAALPSLESFLSRRLKGSIKRAKSQPKLDRTSSFRHMILPRFRSADQERTRLMQSFKESHSHESLLSPSSAAEALDLTLDEDAIIKPVHSSILGQEYCFEVITASGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRTDTVFWGEHFEFNNLPAVRNLRLHLYKETDKKRRKEKSTYLGLVSIPISSITGRQFVEQWYPVIQPSVLAKGGGVGGGKIINASLRLKSRFQTMSILPMELYKEFAEYVTNNYRTLCAVLEPLLSVKSKEEVACALVHILQSTGKAKDFLSDMAMCEVDRFIDREHLIFRENTLATKAIEEYLKLIGHKYLKDVLGDFIRALYESEENCEVDPMRTPPSILPEHQANLRMCCELALCKIINSYCAFPRELKEVFASWRVRCAERGREDIADRLISGSLFLRFLCPAIMSPSLFNLTQEYPDEQTSRTLTLIAKVVQNLANFSKFGSKEEYMCFMNEFLEMEWGSMQQFLYEISNLDSVSNAGAFEGYIDLGRELSILHSLLWEVMAQLSKSSIRSWFIVSKDAIIKLGPLPRLLNDISMALRNPHLQRQPSHQTDRQPAERQTDRLLSRPSFNRGVSSEFQNLMMRDLNSSVEITRLPSPTSAMSSGGAPPSRAGMAGFADRDHPHRASSKDVFYGARPPLARSSPAYCTSSSDITDPDPKDSRMNSVSNLQSMGDMLNSSQASIAGLGSYGGLAGLGGGLGGQLRAGGRMSAGSGGSSMSGGLRLSQLSQMGTTTDSLSQQQQQQAAALRFPLSFQNPLFHLAADGPQLHHQHSRAQPPPPLLLAPEPDGSHPTYIPQFAHGGFSRSEDLSTLRPGPHLGQPSIIHSHSYSDDYSRHNQSDYGRRQISMHMQEQQQMAGMASQTGTSHSSLATPPSTVQPVRQSSMAPPTQRMKSQPSHQLSVSSAAGAPASKTRPQSGNLLQSPESGFGGRQQGPRQQLSVKDSTPPGLPHQQSSTRESQGSQGSQGGTPQSTQQSKSHQERQQVQQQHLLKPTMSKQGSSQSPSTLNPQTPASERTVAWVSNMPHLSADIESSRIDREEFKLKEYSKSMDESRLDRVREYEEEIHSLKERLMMSHRKLEEYERRLLTQEQQTNKILLQYQSRLDDSERRLRQQQMEKDNQIKGIIDRLMAVEDELRVGVVPEHKPRVFADQEKQLSALGSADPGVSFGGEMTSASGFVGVSPSDKSSTRSPQNGIASFPLVPPPRSIPHAQLWPNGNQKSAMDWRASLEGEQVNNNANQI
Protein: FG-GAP repeat protein, putative (Q582L3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Trans sialidase, putative
- Heat shock protein 83
- Heat shock protein, mitochondrial, putative
Sequence:
MTLTGNITTIFCVLVILCTTVVNAIPLEWSEPLAHKSPHQRVLQEDLLPHARFAPTNASTTAHTCRSGVYLEWSTRVGSSVLATPRIVDLNYDGNKEILVPTYSQYIEAVDGASGADIAGFPFVHPNIKTYASPIPVDILDDGATEWLVAMYTGELLLIGGEGETRGGVKVPSLPIKKRWFHRNISNSVPANGTLAETPAEVVWMQETLRMKRVNDLVFRERQLNSTDVIGSSKLKGHDSAGEDGNGESTDDKGGEVLPRKTVHGAVDQRPLNQEDAQRRRKMEKIDEMFEFLDPEDGAVEDPADDPNHLGSDVSKDPRGIGTDGWLSAEARESMDLLYHPELYKSSINFEEEYDPFNSNNLLNPTNVATAEDEVAVDPHIMSTPVVASVDGRGETDVVLHVSYYFDPRDYERRGVELSQDGAQVDNYVADVLMVVNLARGEVKWLKVLHLTTKNDTAPAFAFSSPTVTSINDRKQRDIFVTTTAGAIFGFQGDGMQLKGWPVWMNSSITASVSVEDVDGDGVADVCTGDALGYVACFTKEGKKIWSKRFSGAVGDHIAFGDINGDGDMDMAFGTATGLIYAVKGSDGSLLPQFPIATEGPIVASPLLVRLDNASDPKQVDEKGLHIIVPSHDGVLYIVKGTTGCVDAIDTDEKSSVMVLADDVTGNGMLDLVVSTLSGSIMVFGTATKFHPLKAWPSRVKSLNGFTAAEGHIGVFIHPSSRVPRDIHGDKFSLTVTIYDDRKGKDTGQLYNLAFTLGPHVSLGRYLFDTPGTYAIQMHSPLVRMYGTVSVVLTLPDGQMYEDTLALSFNMHFLESVKYTFLIPFLAVWLAHSFVMEKHQVPLTG
Protein: Uncharacterized protein (Q384W0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVKEQLRAFRYIAGTRDIPWAHLRSVNVAAHHTVAPDLQLMKNLISLVAECDVSTAVVANTSETDMHQLLSLLQLSLQFVLWSQSVMKGELLEKRTCDAAKRISSNSMGRLEEKLEASRREQSRLREERDALKVTCRTLESRALQAESKVRCLEKELRDERTLFQENVSLLAAAQHKQGGMKAGKRADNGISSPPAHQRQREGADRNDLQRGHNFGKMLKQTRTEVLLDAPNDQLRRHSQSCSGLSVSNTTSCCAERESLLCLQGEERRVRLSKTPSLHHTPRKSEEPAQPEVVLAVGAIEKLRAEVEAAQRQITMSCEAVHSSLSNAMKSNVDETKAIVQGVGQWMNNLCDSVSKEKEQELQEVKTFLAKWKEEAQQMLDSQVVTVTERLNKEFMIKQQQLRQQQCSSSSSVAPLGSSAATNGKECSCRHCNQRFPPSSLSDHEAECDHRFVNCEKCGRPVMVRLLPKHKCASRDNSESDIHEISSQIQPSSMMLLETQKELRLLLEEDQEEGSTISSAVL
Protein: Vomeronasal type-1 receptor 47 (Vomeronasal type-1 receptor A4) (Vomeronasal type-1 receptor A7) (Q9EQ51)
Organism: Mus musculus (Mouse)
Function: Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Olfactory receptor
Sequence:
MNENSRLHTHSNIRNTFFSEIGIGISGNSFLLLFHIIKFFRGHRPRLTDLPIGLLSLIHLLMLLVAAVIATDIFISWRGWNDIICKFLVYLYRSLRGLSLCTTSMLSVLQAIILSPRSYCLAKFKRKSSHNISCAIIFLSVLYMSISSHLFISITATLNLTMNNFLYVSQSCSLLPLSYLMQSMYSTLLVLREVFLIGLMVLSTSYMVALLCMHRKQAQNLQGTSLSLKTAPEQRATQTILMLMTFFVLMSIFDSIVSSSRAMFLDDSTCYSIYIFVMHIYATVSPFVFMSTEKHLVNFFRSMCEWIINM
Protein: V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D) (P57746)
Organism: Mus musculus (Mouse)
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9Y5K8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y5K8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Y5K8}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P39942}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y5K8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9Y5K8}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250|UniProtKB:Q9Y5K8}.
Interaction partners:
- V-type proton ATPase 16 kDa proteolipid subunit c
- V-type proton ATPase subunit E 1
- V-type proton ATPase subunit F
- V-type proton ATPase subunit H
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit B, brain isoform
- V-type proton ATPase subunit d 1
- V-type proton ATPase subunit C 1
- V-type proton ATPase 116 kDa subunit a 1
Sequence:
MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKIIKEKFEKDLERRRAAGEVMEPANLLAEEKDEDLLFE
Protein: Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) (P70257)
Organism: Mus musculus (Mouse)
Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Isoform NFIX1 acts as a transcriptional activator while isoform NFIX3 acts as a repressor.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSSTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQPNGSGQGKVPGSFLLPPPPPVARPVPLPMPDSKTTSTAPDGAALTPPSPSFTTTGASSANRFVGIGPRDG
Protein: Fascin-2 (Retinal fascin) (Q32M02)
Organism: Mus musculus (Mouse)
Function: Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundles in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20660251}. Cell projection, stereocilium {ECO:0000269|PubMed:20660251, ECO:0000269|PubMed:27811163}. Note=Found mostly in longer hair-cell stereocilia and, in all stereocilia, present in gradient with the highest concentration at stereocilia tips.
Interaction partners:
- Plastin-1
- Xin actin-binding repeat-containing protein 2
- Taperin
- Unconventional myosin-VIIa
- Glutaredoxin domain-containing cysteine-rich protein 1
- Espin
- Radixin
- Twinfilin-1
- Chloride intracellular channel protein 5
- Rho family-interacting cell polarization regulator 2
Sequence:
MPTNGLHQVLKIQFGLVNDADRYLTAESFGFKVNASAASLKRKQIWVLEPDPGQGTAVLFRSSHLGRYLSAEEDGRVACEMDQPGRDCRFLVLPQPDGRWVLQSEPHGRFFGGIEDRLSCFATAISPAELWTVHLAIHPQAHLLSVSRRRYVHLCLQEDEMAADGDMPWGVDALVTLIFQSRRYCLKSYDSRYLRSDGRLVWEPEAHACYTLEFKAGKLAFKDCDGRYLAPVGPAGTLKAGRNTRPSKDELFDLEQSHPQVVLVAANRRYISVRQGINVSANQDEELGHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSANTMFEIEWHGRRVALKASNGRFVCMKKNGQLAAISDFVGEDELFTLKLINRPLLVLRGLDGFVCHRRGSNQLDTNRSTYDVFHLSFRDGAYQIRGRGGGFWYTGSHGSVCSDGDLAEDFLFEFRERGRLAIRALSGKYLRGGASGLLRADADLPVGEALWEY
Protein: A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 150 kDa) (AKAP 150) (P150) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) (D3YVF0)
Organism: Mus musculus (Mouse)
Function: Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses.
Subcellular location: Postsynaptic recycling endosome membrane {ECO:0000250|UniProtKB:P24588}; Lipid-anchor {ECO:0000250|UniProtKB:P24588}. Cell projection, dendrite {ECO:0000269|PubMed:17110924}. Postsynaptic cell membrane {ECO:0000305|PubMed:17110924}; Lipid-anchor {ECO:0000250|UniProtKB:P24588}. Note=Associates with lipid rafts. {ECO:0000250|UniProtKB:P24588}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Disks large homolog 4
- Disks large homolog 1
- Roundabout homolog 2
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Potassium channel subfamily K member 2
- Protamine-2
- Adenylate cyclase type 5
- Glutamate receptor 1
Sequence:
METSVSEIQVETKDEKGPVAASPQKERQERKTATLCFKRRKKANKTKPKAGSRTAEETKKHTPEAGGSGQRQPAGAWASIKGLVTHRKRSEPAKKQKPPEAEVQPEDGALPKKKAKSRLKFPCLRFSRGAKRSRHSKLTEDSGYVRVQGEADDLEIKAQTQPDDQAIQAGSTQGLQEGVLVRDGKKSQESHISNSVTSGENVIAIELELENKSSAIQMGTPELEKETKVITEKPSVQTQRASLLESSAAGSPRSVTSAAPPSPATTHQHSLEEPSNGIRESAPSGKDDRRKTAAEEKKSGETALGQAEEAAVGQADKRALSQAGEATAGHPEEATVIQAESQAKEGKLSQAEETTVAQAKETVLSQAKEGELSQAKKATVGQAEEATIDHTEKVTVDQAEETTVGQAEEATVGQAGEAILSQAKEATVVGQAEEATVDRAEEATVGQAEEATVGHTEKVTVDQAEEATVGQAEEATVGQAEEATVDWAEKPTVGQAEEATVGQAEEATVGHTEKVTVDQAEEATVGQAEEATVGHTEKVTVDHAEEATVGQAEEATVGQAEKVTVDHAEEATVGQAEEATVGQAEKVTVDHAEEATVGQAEEATVGQAEKVTVDQAEEPTVDQAEEAISSHAPDLKENGIDTEKPRSEESKRMEPIAIIITDTEISEFDVKKSKNVPKQFLISMENEQVGVFANDSDFEGRTSEQYETLLIETASSLVKNAIELSVEQLVNEMVSEDNQINTLFQ
Protein: Scoulerine-9-O-methyltransferase 1 (PsSOMT1) (EC 2.1.1.117) (Norreticuline 3-O-methyltransferase SOMT1) (EC 2.1.1.-) (O-methyltransferase 1) (Reticuline 3-O-methyltransferase SOMT1) (EC 2.1.1.-) (Tetrahydrocolumbamine 2-O-methyltransferase SOMT1) (EC 2.1.1.89) (I3V6A7)
Organism: Papaver somniferum (Opium poppy)
Function: Methyltransferase involved in the biosynthesis of the benzylisoquinoline alkaloid noscapine. Catalyzes the conversion of (S)-scoulerine to (S)-tetrahydrocolumbamine. Can convert (S)-tetrahydrocolumbamine to tetrahydropalmatine. Can convert (S)-norreticuline to (S)-norcodamine. Can convert (S)-reticuline to (S)-codamine. Substrate preference is (S)-scoulerine > (S)-tetrahydrocolumbamine > (S)-norreticuline > (S)-reticuline.
Interaction partners:
Sequence:
MATNGEIFNTYGHNRQTATVTKITASNESSNGVCYLSETANLGKLICIPMALRAAMELNVFQLISKFGTDAKVSASEIASKMPNAKNNPEAAMYLDRILRLLGASSILSVSTTKKSINRGGDDVVVHEKLYGLTNSSCCLVPRQEDGVSLVEELLFTSDKVVVDSFFKLKCVVEEKDSVPFEVAHGAKIFEYAATEPRMNQVFNDGMAVFSIVVFEAVFRFYDGFLDMKELLDVGGGIGTSVSKIVAKYPLIRGVNFDLPHVISVAPQYPGVEHVAGDMFEEVPKGQNMLLKWVLHDWGDERCVKLLKNCWNSLPVGGKVLIIEFVLPNELGNNAESFNALIPDLLLMALNPGGKERTISEYDDLGKAAGFIKTIPIPISNGLHVIEFHK
Protein: Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) (Q14568)
Organism: Homo sapiens (Human)
Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIWYESLTDPSKLDSGKELHINLIPNKQDQTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVSFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGERMGRGTKVILHLKEDQTEYLEEQRIKEIVKKHSQLIGYPITLFVEKECDKEVSDDETEEKEDKEEEKEKEEKESKDKPEIEDVGSDEEEEKKDGDKKKKKTKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFCKNLTNDWEDHLAVKHFSVEGQLEFRALLFVP
Protein: Troponin C, slow skeletal and cardiac muscles (Q7ZZB9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Troponin I type 1a
- Troponin I, slow skeletal muscle
- Troponin C, slow skeletal and cardiac muscles
- Troponin T2d, cardiac
- Troponin T type 2b
- Uncharacterized protein
- Troponin T2e, cardiac
- Troponin T2e, cardiac
- Troponin T type 3a
- Troponin I, fast skeletal muscle
Sequence:
MNDIYKAAVEQLTDEQKNEFKAAFDIFIQDAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKTEEELADLFCMFDKNADGYIDLQELKVMLEATGEAITEDDIEELMKDGDKNNDGKIDYDEFLEFMKGVE
Protein: Interferon regulatory factor 3 (K10.5) (VIRF-3) (Q9DUN1)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Interaction partners:
Sequence:
MAGRRLTWISEFIVGALDSDKYPLVKWLDRSTGTFLAPAARNDVIPLDSLQFFIDFKRECLSKGLHPRDLLGSPITAFGKICTTSRRLRRLPGEEYEVVQGINCRRWRLLCAEVKECWWCVHARTHLHSGSSLWEILYQHSVRLEKHRRRPRPFVGENSDSSEEDHPAFCDVPVTQTGAESEDSGDEGPSTRHSASGVQPVDDANADSPGSGDEGPSTRHSDSQPPPADETTVHTDNVEDDLTLLDKESACALMYHVGQEMDMLMRAMCDEDLFDLLGIPEDVIATSQPGGDTDASGVVTEGSIAASAVGAGVEDVYLAGALEAQNVAGEYVLEISDEEVDDGAGLPPASRRRPVVGEFLWDDGPRRHERPTTRRIRHRKLRSAYYRVARPPVMITDRLGVEVFYFGRPAMSLEVERKVFILCSQNPLADISHSCLHSRKGLRVLLPKPDDNNTGPGDVNLLAAVLRSFASGLVIVSLRSGIYVKNLCKSTVLYHGNNPPKKFGVICGLSSRAVLDVFNVAQYRIQGHEHIKKTTVFIGGDPTSAEQFDMVPLVIKLRLRSVTCDD