wanglab/gogpt-training-data huggingface dataset:
Protein: Aminopeptidase (EC 3.4.11.-) (Q7KRW4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
- Glutamate--cysteine ligase
- GCS light chain
- glutathione-specific gamma-glutamylcyclotransferase
- glutathione-specific gamma-glutamylcyclotransferase
- Aspartate aminotransferase
- Aspartate aminotransferase, cytoplasmic
- cystathionine gamma-lyase
- FI04487p
- Cysteine dioxygenase
- Jonah 74E
Sequence:
MLKFNFKPIMVVKEIPLHENLNMESRPMNAATPTTTTTFSKGGRRYSVSLTTAILLASFFICTLLAVGFIVYNFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHISSGNFAVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLLWYIPITFTTDSELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYDRPVQQIVEHIETSVDWMNKNYKSIVRWLENEAQA
Protein: Meis homeobox 2 (D4A2T5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
- PBX homeobox 1.
- PBX homeobox 3
- PBX homeobox 2
- Homeobox protein DLX-2
- Homeo box B13
- PBX homeobox 4
- Pre-B-cell leukemia transcription factor 1
Sequence:
MFLYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPVGMGMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ
Protein: C-C motif chemokine (A2BIR2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU361150}.
Interaction partners:
- Interleukin-8
- Chemokine
- Chemokine
- Chemokine
- C-C motif chemokine
- Chemokine
- C-X-C motif chemokine 11-1
- Chemokine
- Chemokine
- Chemokine
Sequence:
MASSIMSAFCLAVSALLLCFYSSPTVAQADLALDCCLTVSPRVIPKHVILAYQKQSRGDGCPRDAVIFITRKGLNLCAPPASEESWVRDTMTFLDKRREKCKETRFIERRCHALKFMKF
Protein: Long-chain-fatty-acid--AMP ligase FadD26 (FAAL) (EC 6.2.1.59) (Acyl-AMP synthetase) (FAAL26) (P9WQ43)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Catalyzes the adenylation of the long-chain fatty acids eicosanoate (C20) or docosanoate (C22), and potentially the very-long-chain fatty acid lignocerate (C24). Involved in the biosynthesis of phthiocerol dimycocerosate (DIM A) and phthiodiolone dimycocerosate (DIM B).
Interaction partners:
- Phenolphthiocerol/phthiocerol polyketide synthase subunit A
- Phenolphthiocerol/phthiocerol polyketide synthase subunit B
- Phenolphthiocerol/phthiocerol polyketide synthase subunit E
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Phenolphthiocerol/phthiocerol polyketide synthase subunit D
- Phthiocerol/phthiodiolone dimycocerosyl transferase
- Peptide synthetase MbtE
- Doxorubicin resistance ATP-binding protein DrrA
- Probable multifunctional mycocerosic acid synthase membrane-associated Mas
- Possible two component system response transcriptional positive regulator PhoP
Sequence:
MPVTDRSVPSLLQERADQQPDSTAYTYIDYGSDPKGFADSLTWSQVYSRACIIAEELKLCGLPGDRVAVLAPQGLEYVLAFLGALQAGFIAVPLSTPQYGIHDDRVSAVLQDSKPVAILTTSSVVGDVTKYAASHDGQPAPVVVEVDLLDLDSPRQMPAFSRQHTGAAYLQYTSGSTRTPAGVIVSHTNVIANVTQSMYGYFGDPAKIPTGTVVSWLPLYHDMGLILGICAPLVARRRAMLMSPMSFLRRPARWMQLLATSGRCFSAAPNFAFELAVRRTSDQDMAGLDLRDVVGIVSGSERIHVATVRRFIERFAPYNLSPTAIRPSYGLAEATLYVAAPEAGAAPKTVRFDYEQLTAGQARPCGTDGSVGTELISYGSPDPSSVRIVNPETMVENPPGVVGEIWVHGDHVTMGYWQKPKQTAQVFDAKLVDPAPAAPEGPWLRTGDLGVISDGELFIMGRIKDLLIVDGRNHYPDDIEATIQEITGGRAAAIAVPDDITEQLVAIIEFKRRGSTAEEVMLKLRSVKREVTSAISKSHSLRVADLVLVSPGSIPITTSGKIRRSACVERYRSDGFKRLDVAV
Protein: Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4) (O95274)
Organism: Homo sapiens (Human)
Function: Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Anterior gradient protein 2 homolog
- Anterior gradient protein 3
- Dystroglycan 1
- Urokinase plasminogen activator surface receptor
Sequence:
MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHEASRDEEPRLTGGAAGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL
Protein: ECF RNA polymerase sigma factor SigK (ECF sigma factor SigK) (Alternative RNA polymerase sigma factor SigK) (RNA polymerase sigma-K factor) (Sigma-K factor) (P9WGH7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis. Sigma-K controls genes such as mpt70 and mpt83.
Interaction partners:
- Anti-sigma-K factor RskA
- Immunogenic protein MPT70
- Cell surface glycolipoprotein MPT83
- Amine oxidase domain-containing protein
- ECF RNA polymerase sigma factor SigM
- DUF1365 domain-containing protein
- Possible conserved transmembrane protein
- ECF RNA polymerase sigma factor SigC
- Tuberculostearic acid methyltransferase UfaA1
- ECF RNA polymerase sigma factor SigH
Sequence:
MTGPPRLSSDLDALLRRVAGHDQAAFAEFYDHTKSRVYGLVMRVLRDTGYSEETTQEIYLEVWRNASEFDSAKGSALAWLLTMAHRRAVDRVRCEQAGNQREVRYGAANVDPASDVVADLAIAGDERRRVTECLKALTDTQRQCIELAYYGGLTYVEVSRRLAANLSTIKSRMRDALRSLRNCLDVS
Protein: Uroplakin-1b (UP1b) (Uroplakin Ib) (UPIb) (Q9Z2C6)
Organism: Mus musculus (Mouse)
Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Uroplakin-2
- Uroplakin-3b
- Uroplakin-3a
- Uroplakin-1a
Sequence:
MAKDDSTVRCFQGLLIFGHVIVGMCGIALTAECIFFVSDQHSLYPLLEATNNDDIFGAAWIGMFVGICLFCLSVLAIVGIMKSNRKILLAYFIMMFIVYGFEVASCITAATQRDFFTTNLFLKQMLMRYQNNSPPTNDDEWKNNGVTKTWDRLMLQDHCCGVNGPSDWQKYTSAFRVENNDADYPWPRQCCVMDKLKEPLNLDACKLGVPGYYHSQGCYELISGPMDRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY
Protein: Protein transport protein sec13 (O94319)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution (By similarity). Involved in septum formation.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q04491}.
Interaction partners:
- COPII coat assembly protein sec16
- Uncharacterized WD repeat-containing protein C4F8.11
- Uncharacterized WD repeat-containing protein C12G12.01c
- Nucleoporin nup85
- Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05
- Protein transport protein sec24
- Nucleoporin seh1
- Nucleoporin nup189
- Protein transport protein sec31
- Nucleoporin nup107
Sequence:
MTTVDTQHDDMIHDAILDYYGKRLATCSSDQTIKVFSIENNQQTLLETLRGHSGPVWQLGWAHPKFGTILASASYDGHVIVWRETGGVWSELMDHTAHQASVNAVSWAPHEYGALLACASSDGKVSVLEFKDDGSCDTRIFTAHEPGCNAVCWSPPSLSGSVVGQSPAAGPKKLATAGCDNLVKIWAFDAGVNNWILEDTLAGHVDWTRDVAWAPSVGLTKTYLASASQDKNVFIWTKEGDGPWQKTPLTEEKFPDIAWRVSWSLSGNILAVSCGDNKVYLFKESQNKWQLLNELSN
Protein: BMS1 ribosome biogenesis factor (Ribosome biogenesis protein BMS1 homolog) (E7F349)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- WD repeat domain 36
- RNA cytidine acetyltransferase
- RNA terminal phosphate cyclase-like 1.
- Transducin beta-like 3.
- Small subunit processome component 20 homolog
- WD repeat domain 46.
- Nucleolar protein 56
- WD repeat-containing protein 75
- WD repeat domain 43.
- HEAT repeat-containing protein 1
Sequence:
MEKMERKEQKRHQHKHSGPKAQKKNRKKEQGTEPEQDERKRNPRAFSVQSAVRMAKTFHRAQDIKTKKHHIPLVDRTPLEPPPVVIVVMGPPKVGKSTLIRCLIKNFTRQKLSDICGPVTIVSGKKRRLTFIECNNDINSMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHGFPRIMGVLTHLDSFKNNKTLRKTKKRLKDRFWTEVFQGAKLFYLSGMVYGEYQIQEVKNLGRFISVMKFRPLVWQTSHPYVLADRMEDLTDPEAIRLNPKCDRTVSLYGYLRGTFMKNKSQVHIPGVGDFTVSDVGFLPDPCPLPEVIKKRALNVKERLLYAPMAGVGGLVYDKDAVYIDMPSGHAKKQQEEVRPTTELVQSLIGTQATLDAKMAASKVSLFTGTAALTPEEVEENGKQNPTESREWDENTQRERRRAVFADEGEDDGDEDDDDDDDDEEEVEDEDEENEEGETTLEKQDKTATGPPVKKQKVEDPAEMPAFADSEDELEKSEGEESEEDESEEEDEEEMEEGKSAKKSSGPDSGLCSEEEEEDDDDDDDDEEDDSDMQEDEDKSKNPEEEDINTEEVEMGFETAGALRWKEGLAEKATEAYLRQQRAAPNLRKLVYGTVAEEEEEGSDDDEELGGLFKVSRPEKSKKVRADMMDCSRFQPDSSHDWDQEEMLASIRDCFVTGKWEEDKDAATLLKEDDELYGDFEDLETGEVHKAKTGNKDKAEEENGDDDDDDDDDEEEEEAPQMKLDDDEVQKNKRLEKKRRLKERFDAQYDDGDATYFDDLKEEMQKQAELNRQEFEDVDDEIRVQYEGFRPGMYVRVEIPAVPCEFVTNFDPHYPTILGGLGASEGNVGYLQMRLKKHRWHNRILKTRDPLILSLGWRRFQTIPLYYIEDHNGRHRLLKYTPEHMHCGATIWGPITPQGTGFLAVQTIGGVKANFRIAATGVVLDLDKSVSIVKKLKLIGYPYKIFKNTCFIQGMFNTILEVAKFEGASIRTVSGIKGQIKKALRTPPGAFRATFEDRLLMSDIVFLRSWYPVSVPRLYNPVTSLLMPVGQKHTWSGMRTLGQLKHDLGIHNKPKQDSLYKPIERQVRHFNPLRIPKELQKALPFKSKPKYMQSKGKTPRDLQRPAVIREPHEKKVAALLDALTTVYSYKTKKAIAEQRTKHKEFLKQKEKQEAERQQRLKVEKKKTYRAMGQKEKKKLKSSLKGTSKDN
Protein: Phosphatidylglycerophosphatase C (EC 3.1.3.27) (Phosphatidylglycerolphosphate phosphatase C) (PGP phosphatase C) (P0AD42)
Organism: Escherichia coli (strain K12)
Function: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:21148555}; Single-pass membrane protein {ECO:0000269|PubMed:21148555}.
Interaction partners:
- Phosphatidylglycerophosphatase A
- Phosphatidylglycerophosphatase B
- Cardiolipin synthase C
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Cardiolipin synthase A
- Cardiolipin synthase B
- Histidine biosynthesis bifunctional protein HisIE
- Histidine biosynthesis bifunctional protein HisB
- Imidazole glycerol phosphate synthase subunit HisF
Sequence:
MATHERRVVFFDLDGTLHQQDMFGSFLRYLLRRQPLNALLVLPLLPIIAIALLIKGRAARWPMSLLLWGCTFGHSEARLQTLQADFVRWFRDNVTAFPLVQERLTTYLLSSDADIWLITGSPQPLVEAVYFDTPWLPRVNLIASQIQRGYGGWVLTMRCLGHEKVAQLERKIGTPLRLYSGYSDSNQDNPLLYFCQHRWRVTPRGELQQLE
Protein: Small ribosomal subunit protein eS19 (40S ribosomal protein S19) (A0A0R4IJ49)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Small ribosomal subunit protein eS17
- Small ribosomal subunit protein eS1
- Ribosomal protein S10
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein eS8
- Large ribosomal subunit protein eL39
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- Small ribosomal subunit protein uS10m
Sequence:
MLIRFQMPGGVTVKDVNQQEFVRALAAFLKKSGKLKVPDWVDIVKLAKHKELAPCDENWFYIRAASTVRHLYLRGGVGVGSMTKIYGGRKRNGVCPSHFSVGSKNVARKVLQALEGLKMVEKDPNGGRRLTPQGTRDLDRIAGQVAAASKKV
Protein: DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) (Q588C7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVADVKIGDDKQSLCELLDWLNGLLQATFSQVEDTCSGAAFCQLMDIIQPGSIDVTKVNFTAEENLDILNNYNLLQEAFSKAQIQKELELTLLVNGDIMTTCDLLTWFKDMYDHNFAKQKCNPQVAFIKPEVVSLKSSREFETIEKENVSSLYNTEETSSNQKTQHVEKTSQESVSWSPLTSFIRKYGSSTLTDDESNNVNSKDCPGQKSFGDITPFWRQTPYCLYLLHGVELEDDKKASVLLLGFFDKETGENKIRLLDVVYPTKESTEDICNYILDTLRKIGIPLFNMAILYSDFPDHEHLVAGLQLMKAEIVSLCGLTDLTGQVCHSGVEKIEFSDLILNLITEIYKHFPSFPADLQALLEDVEGSDIDNLTSQCSLFWRIIKKIPLAWSHLEKYFGSLGTEEEAVCLLLEDPKIKLNVLFLTHALQPLCDFQEIIDQGASVLQLLQDASKLLRLYTQSFLRPKAAEYFHRRGKTSLVQETVGHLPKGEVAVGEQAADFLQQHSEELFDYLETFHSSIISFYTTVTVNIVKRLPLPDSTLRNLSLVLSPGKKLEVTGKMVQDLGVGFGVCIRPDNVSLLTDEFLEYQLIEGGDTGSVDQPTEKYWQTELRIMGNASNFGKLIVSLLALPKTLKKEIIFKQMFQQTDYLKMMRKEDCEEKDMMEDDVTDSSSYKSAPSHLSPETQGSSISDVIDLTEMDEIGPVEIEDIAPMDVDDIVSISSDSETENQKVNVPHVSIVLDDDDDDDDEMTDDDDDYGCEAGEVMWKYSKNKGNTQNEMTDNTYQGGFSVGEMVLGPIEGFGLWPGLVQSWDSERPCGSMRKVIFFGNGMQTEVQADSLLPFSSLAKCFCSNSFATVMAYKDAIFSSLQVASRRSRMFFSPESESKDELLRVMLNWAFGGFEPLGADGLQPQAEYSVKVKKGKRKNPTGKLFNLTVPLNKIPESLDLNNGSVDLGTTDADKKRLYSKWNGRSMQTVKIRRKYKQRNKNIIPTVQIESRQNSQKRHQMVHEFLKNKRKIEDFCLSCGSMSVDIIHPLFEGKLCTNCKFNFTETLYRYDEDGYQSYCTVCCSGMEVILCGHDSCCRSFCVDCLDILVCQGTFDQLKNVDPWTCYLCAPETSSGALKPRHDWSIRVQEFFANDTGMEFEPHRVYPSIPAIQRRPIRVLSLFDGIATGYLVLRDLGFKVEKYVASEIDEESITISMVNHDGKITQVDDVKNITKKHIEQWGPFDLLIGGSPCNDLSIVNPARKGLYEGTGRLFFEYYRLLNVLKPKEDDPQPFFWLFENVTFMQTHVKADICRFLECNPVLVDAVKVSPAHRARYFWGNIPGMNRPIIASQNDKLCLQECLEPGRTAKYEKVRTITTRQNSLKQGTNDAHFPVTMNGKDDHIWITELEKIFGFPKHYTDVKSMGRPQRQRVLGKSWSVPVIRHLLAPLKDYFACDEFPVK
Protein: Long-chain base (LCB) kinase 1 (B3H501)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MQKSGVNRNPSLKVAIPQAQQSLRRLGFCSQIATGGSQQSSPIVFPEKRNKKVKASSRRGEVTNDPQVKPKPDEHRIDIGGGDEKSDLLGSLVYAGKLVLDKRKSASGKDATEIQQPAATDISIKKAVDAKLTSSALVWGSDMLQLNDVVSVTYNVGLRHFTVHAYPIGKGSCGLSCFTKPKRSRKDFRFVAPTVEEAVQWVASFGDQQCFINCLPHPLVAKKQASSELFSVPIDTPPELVFRCKSAPKMLVILNPRSGHGRSIKVFHNVVEPIFKLAGIKMEVVKTTKAGHARELASTVDINLCSDGIICVGGDGIINENSLGRLRWIQKTAFDVLNGLLTRSNPKEGVSIPIGIVPAGSDNSLVWTVLGVRDPISAALSIVKGGLTATDVFAVEWIHTGIIHFGMTVSYYGFVSDVLELSEKYQKRFGPLRYFVAGFLKFMCLPKYSYEVEYLPAQKEDAEGKIRLEKEAVDMQDLYTDVMRRSSREGFPRASSLSSIDSIMTPSVGELDTCSSTHASTEPSEYVRGIDPKMKRLSSGRRDVTAEPEVIHPQAQSTTPNWPRTRSKSRMDKGWMGLTSVQDPPTRCSWGNTGGQDREDISSTVSDPGPIWDAGPKWDTEPSAWDVENSIELPGPPEDIETGLRKQSITPIFEDKWVSRKGHFLGIMVCNHACRTVQSSQVVAPNSEHDDGTMDMLLVHGCGRLRLLRFFILLQTGRHLSLPYVECVKVKSVKIKAGKNTHDSCGIDGELFALHGEVISTMLPEQCRLIGNAPGRHS
Protein: POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B) (Q8TC44)
Organism: Homo sapiens (Human)
Function: Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:23015594, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:32110738, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:20008567}. Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles (PubMed:32060285). Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer. Localizes to the inner scaffold in the central region of centrioles. {ECO:0000250|UniProtKB:Q8BHD1, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:37934472}.
Interaction partners:
- Centrosomal protein POC5
- Protein FAM161A
- POC1 centriolar protein homolog A
- Centrin-2
- WD repeat-containing protein 90
- Centrosomal protein of 135 kDa
- Centrosomal protein of 295 kDa
Sequence:
MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPPVMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFSAVQQKS
Protein: Large ribosomal subunit protein uL2m (60S ribosomal protein L2, mitochondrial) (P0C8K6)
Organism: Oryza sativa (Rice)
Subcellular location: Mitochondrion.
Interaction partners:
Sequence:
MRQSIKGRALRHFTLSTGKSAGRNSSGRITVFHRGGGSKRLQRKIDLKRSTSSIGIVERIEYDPNRSSRIALVRWIEGVLPGRQRKFKTIEEFALPRKILESTTATIFCLFSFSSLSSPLAQGETASLSFGSSLGFPRIAVAGAKPAFFAERMREKKIGKKTFSLCEIRKWRTHCVLWAHRIKRKAALSWQSLRQQKTLELVGAAEHNESKLKADQGSLLPRQVLAYALCSGRPSYLHASRSFYKALLPVEASRFGSLPAKPPIGEGPKDGAYKVDRAPVTYILASHQLEAGNMVINCDCSKPSKSGFLRPAQNAHTYLRFQELGRTVNKGRVEGGSQLAASWPRPPAYRHEILDLNSKVGNSIPLADIRMGTWVHDIECHPGQGAKLARAAGTYAKIIKEPASQCLVRLPSGVEKLIDSRCRATIGIVSNPNHGARKLRKAGQSRWSGRRPIVRGVAMNPVDHPHGGGEGRTKGGRPSVSPWGKPTKAGFRAGVGVGKRRI
Protein: Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (P12295)
Organism: Escherichia coli (strain K12)
Function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Subcellular location: Cytoplasm.
Interaction partners:
- Exodeoxyribonuclease III
- Endonuclease III lyase)
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- tRNA-specific adenosine deaminase
- Adenine DNA glycosylase
- Endonuclease 4
- Formamidopyrimidine-DNA glycosylase
Sequence:
MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGVTIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGIAIPPSLLNMYKELENTIPGFTRPNHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRHHVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQRGETPIDWMPVLPAESE
Protein: Complement regulatory membrane protein (Q9DEG0)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MAVGVFALAVLLAGLGAARAQGSCTLPDKVQNAELTEDASTMSSFPVGTTVSYTCRPGYMRIPGMPVSRTCGENLMWSQIETFCTARSCTHPGELQNGVVHVTDLTFGSAVTFSCEKGYRLHGNRQISCVIQGKVVDWNGPLPLCDRVPCKPPPSIANGRYTEAANYVYQTTVTYSCDDVRTGENPFSLVGSPSIFCTVDENSNGVWSGPPPQCKVVICDNPQVENGRKASGFASQYIYGSSVRFECDPDYVLLGMDVISCTENGTWYPSLPTCKRISEDACGAPKISHGEVVPQKSVYLRGESVQIRCSPRCAFPDGGTEVTVMCQGRNTWSSEPNCACDSEPSDFSPVISHGRIIEGKKSVYSEGDSITIECYAGYTLHGAARIEYIGGGRWTPEVPVCKLSAYIIAIICMIVAVLVFLAAFWIFKKFISQEGKSDSTPHTAKYTSCKA
Protein: Protein REG2 (P38232)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory subunit, binds to type-1 protein phosphatase. Functions with HEX2/REG1 and SNF1 protein kinase to regulate growth. Might regulate SNF1 directly or indirectly.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-2
- Serine/threonine-protein phosphatase 1 regulatory subunit GAC1
- GLC7-interacting protein 2
- Protein phosphatase 1 regulatory subunit SDS22
- Resistance to glucose repression protein 1
- GLC7-interacting protein 1
- Maltose permease MAL31
- Filament protein FIN1
- Serine/threonine-protein phosphatase 1 regulatory subunit PIG1
Sequence:
MTLSNCDSLDNLFQDPPEEEESSKFVEAVRTLMNRNDMGYPPAAANGTYCLKKIKSLNAKQWKINKKRMCMLPAVKKKNFDFHEQRSLILNLNLWKFIKFINCSSKNNYNKNNKHVRSSNNTVKNENVLPLQKHKKVDNDQRLENLFWRSWFKARKRRDIMGKPRERHIKFNDNVEQCIITDEHFIQRLPSTRLNSTDEQRPCSKSELDPCIGNAASKRSFYDYNSVYVASDAIITTAAATAIISSNSGDYQRGHDVRDVPRNVLLQAGETDFSSVLRVDSDLKLSNISHHSPVKPSSTSSHSTFIFESETDTDTDTDAETENDIDAYIDTSIPNLLL
Protein: Transferrin receptor protein 1 (Q5MPX4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU367157}; Single-pass type II membrane protein {ECO:0000256|RuleBase:RU367157}. Melanosome {ECO:0000256|RuleBase:RU367157}.
Interaction partners:
- Serotransferrin
- Transferrin receptor 1b.
- Iron-responsive element-binding protein 2
- Solute carrier family 40 member 1
- Cytoplasmic aconitate hydratase
- STEAP family member 3, metalloreductase.
- Clathrin heavy chain
- Mitoferrin-1
- Apolipoprotein Ba.
- Sorting nexin 2.
Sequence:
MDQARTTISKIFNGEPRSYTRFNLTQNMEGDNSHVEMKLSSDMDEEVEANGVGENQRNGQYYPSKLNQRSPKTVCGFVVGILLLFLFGYLIGYMSNKSTGKTEIKTDCPVFSETAPVRPEIAVSLDWSDLRALLKRKLTTENINSNFKEFSSLSHQAGSSGDEMLANKIMGKFKTLGMNPWTDEHYVKVHDPGASNNRVLFRNNVVGTTEGYLAYSAIKTVQGAALYAHYGRAEDFRRLQEVSADVSEKVVLVRAGLLSYAEKVANAASLNASAVLIYPDPVNYQIKENTALFGHVHLGTGDPYTPGFPSFNHTQFPPAQSSGLPSIPAQTITTKQASEIMSKLGGRSSPREWSDGMLADTQYLLGDKDDIITVEVNNVLVQKKIHNVFGVIKGYLDADRYLVIGVQRDAWGPGFARSTVGTSLLVELARTITDMIKNDGFKPKRSIVFASWSAGEFGGVGATEWLEGYLNSLNLKMFSYISLDDLISGSDSFKAAASPLLYDLLESTMKQVSSPTDSTKSLHEQFAGSNWEKSVIEPMGLSHPSYAFQTFSGIPSLSFRFFTNSRFYPFGTFEDTNQNLDLFTSRKTLVLAKAAGEVAGLVTLRLVHDHLLKLNVAKYTTIIRSYVSQIRSKVESRQMSGRLPPTLTMQWLLSAQGSYDRAASALTSAIRNSDLDDMEQCRIINNRIMRVEGSLLSPYVSPRQTLFRHILLGSGSHTLAALLDHLEAIKGGLESADIDQFKNQFALATWTIQGCANALAGEVWDLDNQI