Protein: Serine/threonine-protein kinase tor (EC 2.7.11.1) (Target of rapamycin) (Q86C65)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Functions as a part of 2 distinct protein complexes TORC1 and TORC2. TORC1 is a rapamycin-sensitive complex that controls cell growth in response to nutrients and growth factors. The second TOR complex, TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2 but not TORC1 negatively regulates phagocytosis. TORC2-dependent regulation of the cytoskeleton may follow differential phosphorylation of pkbA. May have some protein kinase activity, as it appears to phosphorylate pkgB.
Interaction partners:
- SAP domain-containing protein
- Protein raptor homolog
- Protein LST8 homolog
- Protein pianissimo A
- Serine/threonine-protein kinase atg1
- TAP42-like family protein
- Autophagy-related protein 101
- Ras-related GTP-binding protein A
- Ubiquitin-like domain-containing protein
- Ras-related GTP-binding protein
Sequence:
MSQHEQPSIWADALTKLLNDLKSKKEEDRVKASKNLKSYVISQSREMTNENFTKFMNELNNNLIFELVNSSVIPEKIGGIMAIDELIDVDYDENATKITRLANYLRIGLGFNDFTVMLMASKALGRLARSSGTLTAEFVEFEVTRALEWLSGDRIEARRHAAVLVLKELAQNAPTLFYVHASSFVDLIWVALKDPKVAIREGAVEALRACLELISERESRLRLQWYQKIYDEAQKSFKQNGSPESIHGSLITVSELLRNTGDFMLSKFKDICETVLKYKDHRDKLVKKTVLALFPRLAVFCSRDFVLNYFNACMNHLLAALRNQNERPTAFIALGEIAMAVGGSIKPYLDSIVVMIKQGLMTKGKQFCPEVLTCISMLASAVGQSMYPHMQVILPQMIVSSGLTVVLTDALRDLTINLPTLIPNIQYKLLNLISQVLANKPFSEPGAPSPYRKSATPFQGGSIPQLGQNSDVDPQMIALALKTLGSFDFSKHNLLEFVRECVVNYLDDDNIEIRREAAITCAQLMVGTEEPTPTRGHSAVIVGEVLEKLLVVGIADPDPSIRKTVLSSLEARFDHYLAQAENLRSLFIALNDELFEIRELAITVIGRLTIRNPAYVMPSLRKTLIQLLTELEFSGDGRNKEESARLLGHLISASEKLIKPYVEPILKALLPKLRDSNPRVASCVLAALGELSVVGGEEMVQHIDSLLPLIIDTLQDQSSTSKREVALKTLAQLASSTGYVIKPFSKYPMLLDTLLNAIKTERIGSIRREVIKVLGILGSLDPYKHKMNELGKRREDPKANDDKNNNMTNEVITISPSNEDYYPTVALTALMKILRDPSLSSHHTSVIQAVMYIFKSLSLKSIPFLPQIMPPFLHAMNTGEPLFREFLFQQLGSLVSIVKQHIRDYLVNVFALIEKYWNSNLLIPIIKLVEEISSALNDEFKVYLPNLIPQMLNVLHTDRSPKRSPTTKVLRALEVFGTNLDDYLHLVIPAIVKLFEQVDVTTQVRTLAIQTIGRLCKKLNFSDYASRIIHPLARVLDSTESELREETLNTLCALVYQLGSDYAIFIPMVGKVLARREIQSTNYELLISKLLKNQQLMLTPGSGDDGGMGANRFGGDHNGHHLGEDHNNTSTPLDIGVKKLKANEQHLKNAWETSQRSTKEDWGEWIRRFSVELLRESPSPALRSCLSLAQDYHPLVKELFNAGFVSCWTELHEQFQEELVRSLETALLSPNIPPEILQTLLNLAEFMELHEKPLPIDIRTLGALAEKCHAYAKALHYKESEFSQSPSSTIEALISINNQLQQPEAAIGILIYAQKNHSVELKEGWYEKLRRWEDALAAYEKKQKDDPNGGTIENTMGILRCLHALGEWERLSALSSETWKSDINDHTRATIAPLAAAAAWNLVNWDKMDEYVCAMNKDTVEGSFYRAILEVHHDNFTLAHGFIDHARTLVDTELTALLGESYNRAYKVVVRLQQLSELEEIIEYKKCVDSPERRNMIKNTWKTRLRGCQHNVDIWQSILAVHSLVISPHEELDMWLKFVGLCRKGSRLGLAQKTLTMLMGKDPSTTSQFGSVLPNTHPRITFAYIKQLWSAGAKQPAFEKLRTFVQALRDTDDLPLQGRAYLKLGEWQLALGDTLSEASIPHIISSFKAATECDPNWYKAWHSWALINFEVVSHYEQNGGTPEQIGAHLLPAVHSFFKSISLGPDRSLQDTLRLLTLWFKHGAQKEVEAALMQGFNTISIDTWLHVIPQIIARIHAPVLPVRRLLHELIDTIGKEHPQALVYPLTVATKSHSPARLAAAKSLMDKMRKHSATLVDQALPVSQELVRTAILWLEMWYEGLEEASRQYFGDHNPEAMLATLAPLHQILEKGPETTSETSFLQAFGRDLQEALEWSKKYEKTRKEGDLNQAWDLYYQVFRRIYKQLPQMSSLELQYVSPKLLNSNNMELAVPGTYKASENVIRIQSFSQALSVIPSKQRPRKLTIIGSDGLEYTFLLKGHEDLRQDERVMQLFSLVNNLLSANHETAKSHLSIRRFSVIPLSPNSGLIGWVPHSDTLHTLIKDFRDSNKILLSIEHRLMLQMCSDYDNLTLLQKVEVFQYALENSNGLDLHKVLWLKSRNSEVWLDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRHTGHILHIDFGDCFEVAMHRDKYPEKIPFRLTRMLINAMEVSGIEGNFRLTCEAVMNVLRNNKESLMAVLEAFVHDPLINWRLLTPNENNTKHKATNIASNNSTSNSTTKIEGDLNTIDNPINKESPDHEAVAGSLKSSPVHGRQIARNQRVGVDAEQVEAEIVPEALNERALSVINRVNKKLTGRDFSSNETLDVPEQVQKLIDQATSHENLCLSYVGWCPFW