wanglab/gogpt-training-data huggingface dataset:
Protein: Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein (A0A1D8PUA7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Kinetochore protein mis13
- SUMO protease
- Uncharacterized protein
- non-specific serine/threonine protein kinase
- U5 snRNP GTPase
Sequence:
MAPKKQATVVTEQDISNSDNEQLVELINNLVNTKQDELFAKYKAKVESQLENDHQLIEDLQAELKAKDDRIDALLEELSLLKQDPGMEFASPIRKKASGRLNQDELAKERENICFTLDMIELLTGVKVINFENTSDEYIFDIKQSSSVKSGLTMHYQLVLASQPSPEINYIPTFLDALEGEEVEDYENAKILQKILPDYLCENLSFPFDTLAQFYGKVNRALNKK
Protein: Catalase isozyme A (CAT-A) (EC 1.11.1.6) (Q0E4K1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide (By similarity). Involved in environmental stress response. Promotes drought stress tolerance and recovery (Ref.10).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26900141, ECO:0000305|PubMed:21398647}. Cell membrane {ECO:0000269|PubMed:29581216}.
Interaction partners:
- Os09g0544900 protein
- Peroxisomal
- Catalase isozyme B
- Catalase isozyme C
- Superoxide dismutase, mitochondrial
- Superoxide dismutase 2
- Superoxide dismutase 2, chloroplastic
- Superoxide dismutase 1
- Os01g0357200 protein
- Os02g0765800 protein.
Sequence:
MDPCKFRPSSSFDTKTTTTNAGAPVWNDNEALTVGPRGPILLEDYHLIEKVAHFARERIPERVVHARGASAKGFFECTHDVTDITCADFLRSPGAQTPVIVRFSTVIHERGSPETIRDPRGFAVKFYTREGNWDLLGNNFPVFFIRDGIKFPDVIHAFKPNPRSHVQEYWRVFDFLSHHPESLHTFFFLFDDVGIPTDYRHMDGFGVNTYTFVTRDAKARYVKFHWKPTCGVSCLMDDEATLVGGKNHSHATQDLYDSIAAGNFPEWKLFVQVIDPEEEERFDFDPLDDTKTWPEDEVPLRPVGRLVLNRNVDNFFNENEQLAFGPGLVVPGIYYSDDKMLQCRVFAYADTQRYRLGPNYLMLPVNAPKCAHHNNHYDGAMNFMHRDEEVDYYPSRHAPLRHAPPTPITPRPVVGRRQKATIHKQNDFKQPGERYRSWAPDRQERFIRRFAGELAHPKVSPELRAIWVNYLSQCDESLGVKIANRLNVKPSM
Protein: Calcineurin B-like protein 1 (SOS3-like calcium-binding protein 5) (O81445)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a calcium sensor involved in the signaling pathway during growth and development and in response to abiotic stresses. May function as a positive regulator of salt and drought responses and as a negative regulator of cold response. Contributes to the regulation of early stress-related CBF/DREB transcription factors. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to low potassium conditions and in the context of stomatal movement. Involved in response to glucose and gibberellin during germination and seedling development and in response to cold stress. Involved in the calcium-dependent regulation by CIPK26 of reactive oxygen species production by the NADPH oxidase RBOHF.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16814720, ECO:0000269|PubMed:17825054, ECO:0000269|PubMed:17922773, ECO:0000269|PubMed:18502848, ECO:0000269|PubMed:19832944, ECO:0000269|PubMed:23335733}; Lipid-anchor {ECO:0000269|PubMed:16814720, ECO:0000269|PubMed:17825054, ECO:0000269|PubMed:17922773, ECO:0000269|PubMed:18502848, ECO:0000269|PubMed:19832944, ECO:0000269|PubMed:23335733}. Note=The cell membrane localization is S-acylation dependent and is abolished by 2-bromopalmitate (2-BP) treatment.
Interaction partners:
- CBL-interacting serine/threonine-protein kinase 23
- CBL-interacting serine/threonine-protein kinase 1
- CBL-interacting serine/threonine-protein kinase 24
- CBL-interacting serine/threonine-protein kinase 26
- CBL-interacting serine/threonine-protein kinase 5
- CBL-interacting serine/threonine-protein kinase 6
- Potassium channel AKT1
- CBL-interacting serine/threonine-protein kinase 7
- CBL-interacting serine/threonine-protein kinase 9
- CBL-interacting serine/threonine-protein kinase 15
Sequence:
MGCFHSKAAKEFRGHEDPVKLASETAFSVSEVEALFELFKSISSSVVDDGLINKEEFQLALFKSRKRENIFANRIFDMFDVKRKGVIDFGDFVRSLNVFHPNASLEDKIDFTFRLYDMDCTGYIERQEVKQMLIALLCESEMKLADETIEIILDKTFEDADVNQDGKIDKLEWSDFVNKNPSLLKIMTLPYLRDITTTFPSFVFHSEVDEIAT
Protein: SPFH/Band 7/PHB domain-containing membrane-associated protein family (Stomatin-like protein) (Q93VP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Expressed protein
- Prohibitin-2, mitochondrial
- Prohibitin-3, mitochondrial
- Kinetochore protein SPC25 homolog
- Prohibitin-1, mitochondrial
- Flotillin-like protein 2
- ATP-dependent zinc metalloprotease FTSH 10, mitochondrial
- GrpE protein homolog
- Prohibitin-4, mitochondrial
- ATP-dependent zinc metalloprotease FTSH 4, mitochondrial
Sequence:
MNHLVRKSSVGYSALRSVSYLRQSAVTSPPPIFSAAASTVRQFTSAGYPSNSFQLTPPTNWGIRIVPERKAFVIERFGKYATTLPSGIHFLIPFVDRIAYVHSLKEEAIPIPNQTAITKDNVSIHIDGVLYVKIVDPKLASYGVESPIYAVVQLAQTTMRSELGKITLDKTFEERDTLNEKIVEAINVAAKDWGLQCLRYEIRDIMPPHGVRAAMEMQAEAERKKRAQILESEGERQSHINIADGKKSSVILASEAAKMDQVNRAQGEAEAILARAQATAKGLVLLSQSLKETGGVEAASLRVAEQYITAFGNIAKEGTIMLLPSGASNPASMIAQALTMYKSLVINGPSKDHQETQALDETDLEELEDMGEKHISEGSNNRSGSISFDTEKPGHTGEPRFSLQNRNKDPQ
Protein: Ferredoxin (P83526)
Organism: Nicotiana tabacum (Common tobacco)
Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:9989672}.
Interaction partners:
- Ferredoxin--NADP reductase, chloroplastic
- Ferredoxin--NADP reductase, chloroplastic
- Ferredoxin--NADP reductase, leaf-type isozyme, chloroplastic
- Protein NAR1
- Protein NAR1-like
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Sulfite reductase 1 [ferredoxin], chloroplastic
- Thioredoxin H4-like
- Thioredoxin H-type
Sequence:
ASYKVKLITPEGAVEFDCPDDVYILDQAEEMGHDLPYSCRAGSCSSCAGKVTAGNVDQSDGNFLDDDQMADGFVLTCVAYPQSDVTIETHKEEELTA
Protein: Importin subunit alpha (Q9Z0N9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSTNENANSTAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKHGAIDPLLALLAVPDLSSLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPIERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQSHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFNF
Protein: Chromo domain-containing protein (C8VKS5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone H3
- Histone H3
- SET domain protein
- Chromatin remodeling complex subunit
Sequence:
MPPSVAVLSDDESTGESIPYEEAEDKRNGVDDANHADEDEDEDEDEDVYVVEKILGHRFKGDGTLLFQVKWQGYDDPRDETLEPEENLEGAQELLEEYFKLIGGRPEKPSKKRKSVGRPPKAASANKPEPKRRRRSRAADTEETNTSEEKAKIKESVAPDWVPKSKNWENEVKTVDTIVREDGGLVAYLHWNNGKKSKVSIETCYDKCPRKMLKFYEQHLVFKDSDA
Protein: Programmed cell death protein 10-B (Q6NWL1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BUL8}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6NX65}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NX65}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6NX65}. Cell membrane {ECO:0000250|UniProtKB:Q6NX65}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NX65}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6NX65}.
Interaction partners:
- Cerebral cavernous malformations protein 2 homolog
- MOB-like protein phocein
- Krev interaction trapped protein 1
- Sarcolemmal membrane-associated protein
- Cortactin-binding protein 2
- Uncharacterized protein.
- CTTNBP2 N-terminal-like b.
- Suppressor of IKBKE 1
- Striatin-interacting protein 1 homolog
- FGFR1 oncogene partner 2 homolog
Sequence:
MTMEEMKNEAEPNSIVSMTLYAVMYPVFNELGRINPSAAQTLRAAFVKAEKENPGLTQDIIMKILEKKNVEINFTESLLRMAADDVEEYLIKRPEQEFQDLNEKARALKHILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFRKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRLIHQTNLILQTFKTVA
Protein: Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) (Q58CU2)
Organism: Bos taurus (Bovine)
Function: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8BGS1}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q8BGS1}. Cell membrane {ECO:0000250|UniProtKB:Q8BGS1}; Peripheral membrane protein {ECO:0000305}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q5FVG2}.
Interaction partners:
Sequence:
MLSFFRRTLGRRSMRKQAEKDRLREAQRAATHIPAAGDARAVITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLECPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKNSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYSRRTLQVKASTGKPEELSVHNNVSAQSNGSQQAWGVRSTVPVIPSGPVVVEVENLPKSPGADQHDKKWLSAAGDRSQRGGNQWDTRALSPPHPAPRNYPAFVHEHNVKNAGAQQNAHFPGPAAMTDI
Protein: OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) (Q96G74)
Organism: Homo sapiens (Human)
Function: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1.
Subcellular location: Nucleus {ECO:0000269|PubMed:33523931}.
Interaction partners:
- TNF receptor-associated factor 3
- Polyubiquitin-C
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-B
- Ubiquitin-ribosomal protein eL40 fusion protein
- Serine/threonine-protein kinase TBK1
- E3 ubiquitin-protein ligase UBR5
- Zinc finger-containing ubiquitin peptidase 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon
- Ubiquitin thioesterase OTUB1
Sequence:
MTILPKKKPPPPDADPANEPPPPGPMPPAPRRGGGVGVGGGGTGVGGGDRDRDSGVVGARPRASPPPQGPLPGPPGALHRWALAVPPGAVAGPRPQQASPPPCGGPGGPGGGPGDALGAAAAGVGAAGVVVGVGGAVGVGGCCSGPGHSKRRRQAPGVGAVGGGSPEREEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQMKEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTGTSAVEPINTFHGIHQNEDEPIRVSYHRNIHYNSVVNPNKATIGVGLGLPSFKPGFAEQSLMKNAIKTSEESWIEQQMLEDKKRATDWEATNEAIEEQVARESYLQWLRDQEKQARQVRGPSQPRKASATCSSATAAASSGLEEWTSRSPRQRSSASSPEHPELHAELGMKPPSPGTVLALAKPPSPCAPGTSSQFSAGADRATSPLVSLYPALECRALIQQMSPSAFGLNDWDDDEILASVLAVSQQEYLDSMKKNKVHRDPPPDKS
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F1LXV3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Programmed cell death protein 10
- Striatin-interacting protein 1
- MOB-like protein phocein
- Striatin-3
- Serine/threonine-protein kinase 25
- CTTNBP2 N-terminal like
- Serine/threonine-protein kinase 24
- Cortactin-binding protein 2
- TRAF3-interacting protein 3.
- Striatin
Sequence:
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDEESDSEGSDSESSSRESNTHPEWSFTTVRKKPDPKKLQNGEQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
Protein: Transmembrane protein (F4JEG0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MLRIVQITLLCFVLAAGISISAVIAENESIDEILLANGLPLGLFPKGVKGFTVNGETGRFSVYLNQSCQAKYETELHYDEIVSGTIGYAQIRDLSGISAQELFLWLQVKGIRVDVPSSGLIFFDVGVLRKQYSLSLFETPRDCVAVRGDAEFIGSVFDVAIVSSRSNSWKKHCLAGVEEMLLYYTRKMEKIDRCSHLFLKILSTVLISNLRHDSWSDASFFPFPHPSVVSALLSPDCEGDRTERICERKLDGNNDVRIGLEKMLNEWLRFG
Protein: Two-component response regulator ARR11 (Receiver-like protein 3) (Q9FXD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Histidine-containing phosphotransfer protein 5
- Histidine-containing phosphotransfer protein 4
- Pseudo histidine-containing phosphotransfer protein 6
- Histidine-containing phosphotransfer protein 3
- Histidine-containing phosphotransfer protein 2
- Histidine-containing phosphotransfer protein
- Histidine kinase 4
- Histidine kinase 3
- Histidine kinase 2
- Histidine-containing phosphotransfer protein 1
Sequence:
MEKSGFSPVGLRVLVVDDDPTWLKILEKMLKKCSYEVTTCGLAREALRLLRERKDGYDIVISDVNMPDMDGFKLLEHVGLELDLPVIMMSVDGETSRVMKGVQHGACDYLLKPIRMKELKIIWQHVLRKKLQEVRDIEGCGYEGGADWITRYDEAHFLGGGEDVSFGKKRKDFDFEKKLLQDESDPSSSSSKKARVVWSFELHHKFVNAVNQIGCDHKAGPKKILDLMNVPWLTRENVASHLQKYRLYLSRLEKGKELKCYSGGVKNADSSPKDVEVNSGYQSPGRSSYVFSGGNSLIQKATEIDPKPLASASLSDLNTDVIMPPKTKKTRIGFDPPISSSAFDSLLPWNDVPEVLESKPVLYENSFLQQQPLPSQSSYVANSAPSLMEEEMKPPYETPAGGSSVNADEFLMPQDKIPTVTLQDLDPSAMKLQEFNTEAILRSLNWELPESHHSVSLDTDLDLTWLQGERFLANTGLQFQDYSSSPSLLSELPAHLNWYGNERLPDPDEYSFMVDQGLFIS
Protein: Mitochondrial pyruvate carrier (Q57WG7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU363100}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU363100}.
Interaction partners:
- Mitochondrial pyruvate carrier
Sequence:
MSATTKQAIPKLFPKPLHKYVGNGRVFQCLKSYEKYGVVAYLNSVYNLAPSFKWMLSIVPLYGIFVGNPPVEKIDVNSSAALCTTGLLWFVYALLIQPQNSGSRSLAAVNVCLAAVHGYNIYRAMSYKRSKALH
Protein: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (E2) (P75392)
Organism: Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae)
Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Interaction partners:
- Dihydrolipoyl dehydrogenase
- Pyruvate dehydrogenase E1 component subunit alpha
- Pyruvate dehydrogenase E1 component subunit beta
- Cytadherence high molecular weight protein 3
- Probable lipoate-protein ligase A
- Phosphate acetyltransferase
- Ribose-phosphate pyrophosphokinase
- L-lactate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase
- Transketolase
Sequence:
MANEFKFTDVGEGLHEGKVTEILKKVGDTIKVDEALFVVETDKVTTELPSPYAGVITAITTNVGDVVHIGQVMAVIDDGAGAAAPAAPQPVSAPAPAPTPTFTPTPAPVTTEPVVEEAGASVVGEIKVSNSVFPIFGVQPSAPQPTPAPVVQPTSAPTPTPAPASAAAPSGEETIAITTMRKAIAEAMVKSHENIPATILTFYVNATKLKQYRESVNGLALSKYNMKISFFAFFVKAIVNALKKFPVFNGRYDKERNLIVLNKDVNVGIAVDTPDGLIVPNIKQAQTKSVVDIAKDIVDLANRARSKQIKLPDLSKGTISVTNFGSLGAAFGTPIIKHPEMCIVATGNMEERVVRAEGGVAVHTILPLTIAADHRWVDGADVGRFGKEIAKQIEELIDLEVA
Protein: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein) (MTHFD2-like) [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15) (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] (Q9H903)
Organism: Homo sapiens (Human)
Function: Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:D3ZUA0}; Peripheral membrane protein {ECO:0000250|UniProtKB:D3ZUA0}; Matrix side {ECO:0000250|UniProtKB:D3ZUA0}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- Thymidylate synthase
- Methylenetetrahydrofolate reductase
- Aminomethyltransferase, mitochondrial
- Formimidoyltransferase-cyclodeaminase
- Bifunctional purine biosynthesis protein ATIC
- Monofunctional C1-tetrahydrofolate synthase, mitochondrial
- C-1-tetrahydrofolate synthase, cytoplasmic
Sequence:
MTVPVRGFSLLRGRLGRAPALGRSTAPSVRAPGEPGSAFRGFRSSGVRHEAIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTGKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKKIIY
Protein: Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6) (EC 3.6.1.6) (CD39 antigen-like 2) (O75354)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ER31}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856}. Cell membrane {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856}; Single-pass type II membrane protein {ECO:0000255}. Note=Exists as a secreted and membrane-bound forms in the medium of transfected cells, the secreted form is predominant. {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856}.
Interaction partners:
- Ectonucleoside triphosphate diphosphohydrolase 1
- Ectonucleoside triphosphate diphosphohydrolase 3
- Ectonucleoside triphosphate diphosphohydrolase 4
- Soluble calcium-activated nucleotidase 1
- Ectonucleoside triphosphate diphosphohydrolase 8
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Uridine-cytidine kinase-like 1
- Inosine triphosphate pyrophosphatase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenylosuccinate synthetase isozyme 2
Sequence:
MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQKSPAS
Protein: Endophilin-A2 (Endophilin-2) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) (SH3p8) (O35964)
Organism: Rattus norvegicus (Rat)
Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17088211}. Early endosome membrane {ECO:0000269|PubMed:17088211}; Peripheral membrane protein {ECO:0000269|PubMed:17088211}. Cell projection, podosome {ECO:0000250}. Note=Associated with postsynaptic endosomes in hippocampal neurons.
Interaction partners:
- Synaptojanin-1
- Synaptojanin-2
- E3 ubiquitin-protein ligase CBL
- Endophilin-A1
- Endophilin-A3
- E3 ubiquitin-protein ligase CBL-B
- E3 ubiquitin-protein ligase CBL-C
- Epsin-2
- Activity-regulated cytoskeleton-associated protein
- Epsin-1
Sequence:
MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFREMEKKVDITSKAVAEVLVRTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMVRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILEELADKLKRRVREASSRPRREFKPRPQEPFELGELEQPNGGFPCASAPKITASSSFRSGDKPTRTPSKSMPPLDQPSCKALYDFEPENDGELGFREGDLITLTNQIDENWYEGMLHGQSGFFPLSYVQVLVPLPQ
Protein: Putative daunorubicin C-13 ketoreductase DnrU (EC 1.1.1.-) (Q9ZAU1)
Organism: Streptomyces peucetius
Function: Could reduce the 13-carbonyl of daunorubicin to yield (13S)-13-dihydrodaunorubicin. Could also be able to reduce the 13-carbonyl of doxorubicin.
Interaction partners:
Sequence:
MTASTPHHGTPRGGLSGRTVLVTGATSGIGRAAALAVARQGARVVLVGRDPERLRTVTNEVARTAGPAPDAFRADFAELRQVRDLGERLRDRYPRIDVMASNAGGMFWSRTTTQDGFEATIQVNHLAGFLLARLLRERLAGGRLILTSSDAYTQGRIDPDDLNGDRHRYSAGQAYGTSKQANIMTAAEAARRWPDVLAVSYHPGEVRTRIGRGTVASSYFRFNPFLRSAAKGADTLVWLASAPAEELTTGGYYSDRRLSPVSGPTADAGLAAKLWEAGAAAVGDTAH
Protein: Uncharacterized protein (Q584L1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- adenylate cyclase
- Protein kinase, putative
Sequence:
MKSRGFTRQPSEGQDGGPGSPPYFARWSVYDVHEDKSHFSNPHRKSHGAGSNTNDSYGNHNNNNNNGNDEEPGRWWPSGEDELSATSSVLNVHVREKHSRPTINYTVPLQQLVGGAGIAKHNHQAVNIPLFMEDDEDEDENAVGGIAGNDVVIGDSVIGCGGGGGGHKNNSPEEKDAENKEDNWLDYYCRYNCKGNNSCGFSGENVDYSHNYNRNNSQYSHVYSTHSAYGRIPMTSGDADVERGDKRKAPATTPTITVPNGEWTQSFTGVSGAVNPQAPTGATVYTASRMRYKNANSNDGNAHISNVYNINAVSHGSGTNAGKALPPVRQTAATAMATSSASSTIGFEAAAASIIAAAGLPLGTLSLANYIMEGQPRLPSRQPVQKQQQGGFDRNHQELTLKGNPMSSPVSPPPYCYSSVGNTSSLKMAHFSNATGATNNTCISVWTGKSWGNEQNSPFIQIKHAQQPTARGSDGQKQQQQQTKAYSEYLSDLLYFHADFFPPPSPPRGLPFPPSYDAAGTTTSSLYSLSQLSPYCSSCCGRRAALWYHYASKWNITHRLPPPPRTPLPEMREQEESRRRRKQQQQQQQQQQRQQQQYHYQQQQHHYKVEGEYVRDNRQGLPCTPYDISGWMKMCERWFDVAQRQFNYPPENIPVRVSPGFVLRHVALC
Protein: ARM repeat superfamily protein (At4g33945) (Q8L5Z0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Polyadenylate-binding protein 3
- Telomerase reverse transcriptase
- Auxin transport protein BIG
Sequence:
MGVRTISQEAFDDLVRENVEDLGMDPSEALEDALYTLKLQGVDLFGIITCVPGESSVKDNPVIACLDRLKEFDSVSIDGPLRDEVFDEISSLFKNLNELCSSQESGNAAIATKHGAVDLTCSICSKIKISTRSNRVLVPCFKALAVLIRDIQSTERFRNCTGPNIVVDLLNDSSSDSDLLDAGFAVVAAAATGNEVVKQLFMELKIDELILQVLNRESKTTIRALYDAICALLTPDDFRVVASQVYGYARTFAKLGIATALTEALQAGIGSDSLVSASTALKAIAVNDEICKSIAESGGIDTLLRCIDDSGEQGNKTAAKTCCSLLSKLAGSDSNKSTIVEKQGLDKLITLALRFSDDPLVIQEVMLIISIICLRSPDHAAKAIEAGAGDLAVQAMKRFPVAAQMQRNACNMIRNIAVRSAENRTILLANGIEKLIRTAKANNETCRAAATDALRDLGLDNYNN
Protein: Uncharacterized protein YOR020W-A (Q3E824)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:16823961}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- ATP synthase subunit K
- Altered inheritance of mitochondria protein 18, mitochondrial
- ATP synthase subunit e, mitochondrial
Sequence:
MGAAYKVFGKTVQPHVLAISTFIATAAVASYFTTKPKTKNEGKNSSALSQQKSGESSNSDAMGKDDDVVKSIEGFLNDLEKDTRQDTKAN
Protein: Lantibiotic mutacin-2 (Lantibiotic mutacin H-29B) (Mutacin II) (O54329)
Organism: Streptococcus mutans
Function: Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria including M.luteus, S.aureus, Streptococcus, P.micros, P.acidilactici, C.sporogenes, C.diphtheriae, A.viscosus, G.vaginalis, P.acnes, L.monocytogenes and M.smegmatis, and Gram-negative bacteria including C.jejuni, H.pylori and N.gonorrhoeae. Transiently and partially depolarizes the transmembrane electrical potential and pH gradient of susceptible cells, inhibits the uptake of amino acids and depletes the intracellular ATP pool.
Interaction partners:
Sequence:
MNKLNSNAVVSLNEVSDSELDTILGGNRWWQGVVPTVSYECRMNSWQHVFTCC