wanglab/gogpt-training-data huggingface dataset:
Protein: Glutathione S-transferase (EC 2.5.1.18) (GST class-pi) (Q9DDU5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU368105}. Mitochondrion {ECO:0000256|RuleBase:RU368105}. Nucleus {ECO:0000256|RuleBase:RU368105}.
Interaction partners:
- glutathione transferase
- Glutathione peroxidase
- Glutathione reductase
- Cytochrome P450 1A
- Glutathione S-transferase omega 1
- Glutathione S-transferase omega 2.
- Glutamate--cysteine ligase
- Glutathione S-transferase theta 1b.
- Glutathione S-transferase kappa
- Glutathione hydrolase
Sequence:
MAPYTLTYFAVKGRCGALKIMLADKDQQLKENLVTFEEWMKGDLKATCVFGQLPKFEDGDLVLFQSNAMLRHLGRKHAAYGKNDSEASLIDVMNDGVEDLRLKYIKLIYQEYETGKEAFIKDLPNHLKCFENVLAKNKTGFLVGDQISFADYNLFDLLLNLKVLSPSCLDSFPSLKSFVDKISARPKVKALLECENFKKLPINGNGKQ
Protein: Probable cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 9) (Q96WV9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the positive transcription elongation factor b (P-TEFb) which consists of cdk9 and pch1, and which phosphorylates the C-terminal domain (CTD) of RNA polymerase II and spt5.
Subcellular location: Nucleus.
Interaction partners:
- Cyclin pch1
- Transcription elongation factor spt5
- mRNA cap guanine-N
- DNA-directed RNA polymerase II subunit rpb1
- CTD kinase subunit beta
- CTD kinase subunit gamma
- Serine/threonine-protein kinase crk1
- Transcription elongation factor spt4
- RNA polymerase-associated protein C651.09c
- Cell division control protein 73
Sequence:
MKRSSSVSVEDEKSARRKLDVVPKLHFVGCSHLTDYHLMEKLGEGTFGEVYKSQRRKDGKVYALKRILMHTEKEGFPITAIREIKILKSIKHENIIPLSDMTVVRADKKHRRRGSIYMVTPYMDHDLSGLLENPSVKFTEPQIKCYMKQLFAGTKYLHDQLILHRDLKAANLLIDNHGILKIADFGLARVITEESYANKNPGLPPPNRREYTGCVVTRWYRSPELLLGERRYTTAIDMWSVGCIMAEMYKGRPILQGSSDLDQLDKIFRLCGSPTQATMPNWEKLPGCEGVRSFPSHPRTLETAFFTFGKEMTSLCGAILTLNPDERLSASMALEHEYFTTPPYPANPSELQSYSASHEYDKRRKREQRDANSHAFEQTANGKRQFRFMTRGPSDPWYGIRRPNYNSQPQYQRGSYNREGGNMDRSRNVNYQPKRQQNFKPLTSDLPQKNSEFSETNAMNQTSNHSHADGQRYYRPEQDRSQRLRNPSDYGRQGRQSSQSQQPAWNVSSRYQNNSKVQTTSRASENADTNKTQHNIKYIDSYVPEYSIARQSANQKTNEQHPSSTSLHQQSTSDLKSPSFHENSNVDDTPK
Protein: Proline-rich receptor-like protein kinase PERK9 (EC 2.7.11.1) (Proline-rich extensin-like receptor kinase 9) (AtPERK9) (Q9SX31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Could be involved in the negative regulation of root growth.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase KIPK2
- Serine/threonine-protein kinase KIPK1
- At2g43770
- Putative pectinesterase/pectinesterase inhibitor 28
- COMPASS-like H3K4 histone methylase component WDR5B
- Phosphatidylinositol/phosphatidylcholine transfer protein SFH3
- Protein FAR1-RELATED SEQUENCE 11
- Nuclear pore complex protein NUP62
- Protein transport protein SEC31 homolog B
Sequence:
MATTPVQPPVSNSPPVTSPPPPLNNATSPATPPPVTSPLPPSAPPPNRAPPPPPPVTTSPPPVANGAPPPPLPKPPESSSPPPQPVIPSPPPSTSPPPQPVIPSPPPSASPPPALVPPLPSSPPPPASVPPPRPSPSPPILVRSPPPSVRPIQSPPPPPSDRPTQSPPPPSPPSPPSERPTQSPPSPPSERPTQSPPPPSPPSPPSDRPSQSPPPPPEDTKPQPPRRSPNSPPPTFSSPPRSPPEILVPGSNNPSQNNPTLRPPLDAPNSTNNSGIGTGAVVGISVAVALVVFTLFGIFVWCLRKREKRLSAVSGGDVTPSPMSSTARSDSAFFRMQSSAPVGASKRSGSYQSQSGGLGNSKALFSYEELVKATNGFSQENLLGEGGFGCVYKGILPDGRVVAVKQLKIGGGQGDREFKAEVETLSRIHHRHLVSIVGHCISGDRRLLIYDYVSNNDLYFHLHGEKSVLDWATRVKIAAGAARGLAYLHEDCHPRIIHRDIKSSNILLEDNFDARVSDFGLARLALDCNTHITTRVIGTFGYMAPEYASSGKLTEKSDVFSFGVVLLELITGRKPVDTSQPLGDESLVEWARPLISHAIETEEFDSLADPKLGGNYVESEMFRMIEAAGACVRHLATKRPRMGQIVRAFESLAAEDLTNGMRLGESEVFNSAQQSAEIRLFRRMAFGSQNYSTDFFSHSSYNSRDANV
Protein: Lost PHDs of trr, isoform B (A0A0B4LGG6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSTNVVVSMEEKAVADDLPYFPEKFPGKVCCLCNLGEKSALGQGEILQLKAPAPAEIKDKYPTDRLREDGSRLLYGPKQAASSSGDCHYELDKIGQPDVVHPAEFLDEGFVYVHRMCIMWSLRKSQISDADGAYFATHFAEFLEQKCNFCGRYGASINCKMNCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSLGDLSKLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKCEQCQKTYHASCLRPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPICQKAYRAASHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSSEQLSLKEIELDPLEGKPTMDPSSDELHKLPTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKGRQLALPTISSDRCLSRSMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQALGNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNILRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVFAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTYNGNAYDMGNYVGGSAQAASNNPNPHHVMPNVNDNLVIKATMQRTQVHTTAASTLKMTTVDNRLELNTAVYGTEPIGDKKLRNLLQKNSTEPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPMLSISGKSQPSEGRSLEQDVKLGEPQEATSSAVELENVGFSDLLGGLGEGDDDDLLKSLTSEMGDDFNILEYADPELDVNVLNSLDFDDNEKCST
Protein: Serine/threonine-protein phosphatase BSU1 (EC 3.1.3.16) (Bri1 suppressor protein 1) (Q9LR78)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphatase that acts as a positive regulator of brassinosteroid (BR) signaling. Dephosphorylates BES1, a transcription factor that regulates the expression of BR-response genes, thereby playing an important role in the regulation of response to BRs. Inactivates the negative regulator of BR signaling ASK7/BIN2 by dephosphorylation at 'Tyr-200'.
Subcellular location: Nucleus {ECO:0000269|PubMed:14977918}.
Interaction partners:
- Serine/threonine-protein kinase BSK1
- Shaggy-related protein kinase eta
- Serine/threonine-protein kinase BSK3
- Serine/threonine-protein kinase BSK7
- Serine/threonine-protein kinase BSK8
- Serine/threonine-protein kinase BSK2
- Serine/threonine-protein kinase BSK11
- Probable inactive receptor-like kinase BSK12
- Serine/threonine-protein kinase BSK4
- Shaggy-related protein kinase iota
Sequence:
MAPDQSYQYPSPSYESIQTFYDTDEDWPGPRCGHTLTAVFVNNSHQLILFGGSTTAVANHNSSLPEISLDGVTNSVHSFDVLTRKWTRLNPIGDVPSPRACHAAALYGTLILIQGGIGPSGPSDGDVYMLDMTNNKWIKFLVGGETPSPRYGHVMDIAAQRWLVIFSGNNGNEILDDTWALDTRGPFSWDRLNPSGNQPSGRMYASGSSREDGIFLLCGGIDHSGVTLGDTYGLKMDSDNVWTPVPAVAPSPRYQHTAVFGGSKLHVIGGILNRARLIDGEAVVAVLDTETGEWVDTNQPETSASGANRQNQYQLMRRCHHAAASFGSHLYVHGGIREDVLLDDLLVAETSQSSSPEPEEDNPDNYMLLDDYLMDEPKPLSSEPEASSFIMRSTSEIAMDRLAEAHNLPTIENAFYDSAIEGYVPLQHGAETVGNRGGLVRTASLDQSTQDLHKKVISTLLRPKTWTPPANRDFFLSYLEVKHLCDEVEKIFMNEPTLLQLKVPIKVFGDIHGQYGDLMRLFHEYGHPSVEGDITHIDYLFLGDYVDRGQHSLEIIMLLFALKIEYPKNIHLIRGNHESLAMNRIYGFLTECEERMGESYGFEAWLKINQVFDYLPLAALLEKKVLCVHGGIGRAVTIEEIENIERPAFPDTGSMVLKDILWSDPTMNDTVLGIVDNARGEGVVSFGPDIVKAFLERNGLEMILRAHECVIDGFERFADGRLITVFSATNYCGTAQNAGAILVIGRDMVIYPKLIHPHPPPISSSEEDYTDKAWMQELNIEMPPTPARGESSE
Protein: Serine/threonine-protein kinase TOR (EC 2.7.11.1) (A0A1D8PHX3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Target of rapamycin complex subunit LST8
- Ubiquitin-binding TORC1 subunit
- Stress-activated map kinase-interacting protein 1
- TORC2 complex subunit
- GTP-binding protein
- Serine/threonine-protein kinase SCH9
- Serine/threonine-protein kinase ATG1
- Tco89p
- GTPase
- TEL2-interacting protein 1
Sequence:
MSASASTSAQLQVVDGVALTEIFKGLTSTSEEERSKYAEELHNYLSSIARDLSSEQFNRYNNDINKTIFDLLHGEKTSEILGGIAALNALIEFDSGVGKENAGKTARFSNYLGSLILSNDLVIMKQAIRTLGKLATLGGNLTGDFVDFEAKRAIEWLQSDSKQHENRRHAAILIITSLADNASTLLYPLINQVLENLWTPLRDHKLIVREDAAIALEKCMHIIYDRDVNARSFWIKRMIESASKLLNENDAADGADSNSSYNITFSGQSTENIHGSLLTYRELLKYYKDPFIVSRFEQIYENTYLYKNHKVAIIRQELTNIFPLLCKVNTELFVEKYLHRTLYYYLSQLKKYKSQNNETANTDKSAIFKSIGLIALEVGNQMATYLDAILDNIREGLSYTSNAGVQSILAKAASNESPNISTTNIASLASGSKYTASRKETEPAIFDCISKLSIAVGPALTKHLQRDILDMMFANCSLSKHMQDVLQVLIENIPTLTNLINEKLLNLLSLVLSGKGFQPPGSPFGTIKVNASLARDCRLIMISRDTGMSINTILMNQERYEKLDSKILIQALEMLAFFKFENYQLNEFVRYCTITYLEHNNAKVRLTATVTSCQIFVKDPICQQVSVNALNTVNEVLGKLVSISITDPAPEIRLAGLNCLIKAGNFDPQLSQANNVRLLFIALNDEVFGVRKVAIQILGRLSCINPAYIVPSLRKTLIQLLSKLEYSTTSRKKEESAILLSLLISNSKELTRPYVKPIVDALLPKAKDLSSSVASSAIKCLGELSVVGGEDLKPFIPDLMPLILDTFQDQSSSYKRDAALRTLGQLAFSSGYVIQPLLDYPQLLGMLVAILKSETSPDIKRETVRLLGILGALDPYKHREVEQNSKNIPVEQNAPPVDVALLMQGMSPSNEEYYPKVAITNLMKILKDPSLSIHHTKVIQAVMYIFQTLGLRCVAFLPQIIPGIINVMHTCQLSMLKFYFQQLGDIVLIVKQHIRPFLDDIFKVIKEFFNAGSQLNIQVTIINVIQSVSRALDGEFKMYLPEVLTLMIGVFEEDKSAKRSPSLHVLKSFVVFGSNIEEFVDIIVPHIVKLFETGPVELRRAAIETIGRLSKNIMLNDMASRIIHPILRILGQGNIDLRESCINTLTYMLVQLGPEFTVFIPVIKKTLLQKNIHAIKFEQLVGKLIGGDPLPLHLDIYKDYDYSLYDIADTDMPSKKLPVNQASLKAAWDASQRRTKEDWQEWIGRLSKELLLQSPSHAIRACAGLASDYYPLAKDLFNASFASCWSELYSQHKEELVESFCIALSSPSNPPEIHQTILNLAEFMEHDDKPLPMSISTLGQYAQRAHAFAKALHYKELEFYDQPTTPTIESLISINNQLQQSDAAIGILKHAQLHHDLQLKETWYEKLQRWDDALKAYNEREKIEPENMEITIGKMRCLHALGEWEQLSELARSKWDNSSSEIKRSVAPLAAAAAWGLSQWDRMDACIKVMKAESPDKAFFNAILSLHRNNFDDASVHILKARDLLVTEITALVSESYNRAYGVVVRVQMLAELEEIIKYKCLPSGSEKRAVMRKTWNTRLLGCQRNVDIWQRMLKVRALVIKPKQDMDMWIKFANLCRKSGRLNLAEKSLNLLLEEGSPENPSRAPPQVVYAQLKYMWAKGQRPEALRHLVDFTTRMSQDLGLNPNDLITQPLPSEGPGIPKHVEEYTKLLARCFLKQGEWQIALNSNWRSETSEIILGAYLLATHFDNKWYKAWHNWALANFEVISLYTSQNTSANNKIEILQDERNGSTEDGHSELKRAEQQKQQQQQQQQQQQQANIIPIEAVQRHVIPSIKGFFHSIALSNSNSLQDMLRLLTLWFKFGGIPEAAKAMTEGFNMVKIDNWLEVVPQLISRIHQPNEIVSRSLFALLTDLGKAHPQALVYPLTVAITSESTSRKKAAQSIIEKMRVHSPSLVDQAELVSRELIRVAVLWHEQWHDALEDASRFFFGEHNTEKMFETLEPLHQMLQKGPETMREQAFANAFGRELTDAYEWVLNFRRTKDITNLNQAWDIYYNVFRRVSKQVQSLASLELQYVSPDLKHAQDLELAVPGTYQAGKPVIRIIKFDPTFSIISSKQRPRKLSCRGSDGKDYQYALKGHEDIRQDNLVMQLFGLVNTLLVNDPECFKRHLDIQQYPAIPLSPKVGLLGWVPNSDTFHVLIKGYRESRSIMLNIEHRLLLQMAPDYDFLTLLQKVEVFTSAMDNCKGQDLYKVLWLKSKSSEAWLDRRTTYTRSLAVMSMVGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKYPERVPFRLTRMLNYAMEVSGIEGSFRITCEHVMRVLRDNKESLMAILEAFAYDPLINWGFDFPTKALAESTGIRVPQVNTAELLRRGQIDEKEAVRLQKQNELEIRNARAALVLKRITDKLTGNDIKRLRGLDVPTQVDKLIQQATSVENLCQHYIGWCSFW
Protein: Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4) (P78413)
Organism: Homo sapiens (Human)
Function: Likely to be an important mediator of ventricular differentiation during cardiac development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein Nkx-2.5
- Heart- and neural crest derivatives-expressed protein 2
- A-kinase anchor protein 11
Sequence:
MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATARHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAAAYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAGANVLTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
Protein: Vacuolar membrane protein PEP3 (Carboxypeptidase Y-deficient protein 3) (Vacuolar morphogenesis protein 8) (Vacuolar protein sorting-associated protein 18) (Vacuolar protein-targeting protein 18) (P27801)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
Subcellular location: Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Interaction partners:
- Vacuolar morphogenesis protein 7
- Vacuolar protein sorting-associated protein 3
- Vacuolar morphogenesis protein 6
- Vacuolar protein sorting-associated protein 41
- E3 ubiquitin-protein ligase PEP5
- Vacuolar protein sorting-associated protein 8
- Syntaxin VAM3
- Ypt/Rab-type GTPase YPT7
- Vacuolar protein sorting-associated protein 16
- Vacuolar protein sorting-associated protein 33
Sequence:
MIKTRIEEVQLQFLTGNTELTHLKVSNDQLIVTTQRTIYRINLQDPAIVNHFDCPLSKELETIMNVHVSPMGSVILIRTNFGRYMLLKDGEFTQLNKIKNLDLSSLHWINETTFLMGIKKTPKLYRVELTGKDITTKLWYENKKLSGGIDGIAYWEGSLLLTIKDNILYWRDVTNMKFPLVLPDESEQFERLKHHAIKKFDSYNGLFAWVTSNGIVFGDLKEKQMEKDPASNNFGKFLSSSKVLLNFELPDYQNDKDHLIKDIVLTAFHILLLRKNTVTMVSQLNNDVVFHETIPRHQLTGSNTDSNEKFLGLVRDSVKETFWCFSNINVFEIIIENEPNSVWNLLVRDNKFDKALSLKGLTVREIESVKLSKAMYLFHTAKDFHSAAQTLGSMKDLSHFGEIALNFLQIKDYNDLNVILIKQLDNVPWKSTQVVLSSWIIWNFMKQLNDIELKINTTKPASTDEDNLLNWNLNLKEKSNELTKFLESHLEKLDNETVYQIMSKQNRQNELLIFASLINDMKFLLSFWIDQGNWYESLKILLTINNHDLVYKYSLILLLNSPEATVSTWMKIKDLDPNKLIPTILKFFTNWQNNSKLITNISEYPENYSLTYLKWCVREVPKMCNPIVYNSILYMMITDPRNDMILENDIIKFMKSNENKYDLNFQLRLSLKFKKTKTSIFLLTRLNLFEDAIDLALKNNLIDDCKVIVNDEILIEDYKLRKRLWLKIAKHLLLSMKDIDIKQLIRTILNDSNEILTIKDLLPFFNEYTTIANLKEELIKFLENHNMKMNEISEDIINSKNLKVEINTEISKFNEIYRILEPGKSCDECGKFLQIKKFIVFPCGHCFHWNCIIRVILNSNDYNLRQKTENFLKAKSKHNLNDLENIIVEKCGLCSDININKIDQPISIDETELAKWNE
Protein: TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP) (O75663)
Organism: Homo sapiens (Human)
Function: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17944932}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 4 catalytic subunit
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 6 catalytic subunit
- Immunoglobulin-binding protein 1
- Serine/threonine-protein phosphatase 4 regulatory subunit 2
- Dual specificity mitogen-activated protein kinase kinase 7
- Leucine carboxyl methyltransferase 1
Sequence:
MMIHGFQSSHRDFCFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKISSLMHVPPSLFTEPNEISQYLPIKEAVCEKLIFPERIDPNPADSQKSTQVE
Protein: Ribonuclease P protein component 3 (RNase P component 3) (EC 3.1.26.5) (Rpp30) (O59543)
Organism: Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Not absolutely essential for activity in vitro, however it strongly stimulates activity. Binds RNase P RNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00756}.
Interaction partners:
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS11
- Ribonuclease P protein component 2
- Ribonuclease P protein component 4
- Small ribosomal subunit protein eS6
- Endoribonuclease Nob1
- Ribonuclease P protein component 1
- Large ribosomal subunit protein eL8
- RNA-binding protein
Sequence:
MVGGGGVKFIEMDIRDKEAYELAKEWFDEVVVSIKFNEEVDKEKLREARKEYGKVAILLSNPKPSLVRDTVQKFKSYLIYVESNDLRVIRYSIEKGVDAIISPWVNRKDPGIDHVLAKLMVKKNVALGFSLRPLLYSNPYERANLLRFMMKAWKLVEKYKVRRFLTSSAQEKWDVRYPRDLISLGVVIGMEIPQAKASISMYPEIILKRLKY
Protein: ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) (Q9NZ52)
Organism: Homo sapiens (Human)
Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation. Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination. Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775}; Peripheral membrane protein {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775}. Endosome membrane {ECO:0000269|PubMed:15039775}; Peripheral membrane protein {ECO:0000269|PubMed:15039775}. Early endosome membrane {ECO:0000269|PubMed:11950392}; Peripheral membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000250|UniProtKB:A0A0G2JV04}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Rab GTPase-binding effector protein 1
- Cation-independent mannose-6-phosphate receptor
- Cation-dependent mannose-6-phosphate receptor
- Polyubiquitin-C
- ADP-ribosylation factor 6
- ADP-ribosylation factor-binding protein GGA2
- ADP-ribosylation factor-binding protein GGA1
- ADP-ribosylation factor 1
- Beta-secretase 1
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMALPEEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQCSNQGTLIDLAELDTTNSLSSVLAPAPTPPSSGIPILPPPPQASGPPRSRSSSQAEATLGPSSTSNALSWLDEELLCLGLADPAPNVPPKESAGNSQWHLLQREQSDLDFFSPRPGTAACGASDAPLLQPSAPSSSSSQAPLPPPFPAPVVPASVPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQLLEEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL
Protein: Tumor protein D52 (mD52) (Q62393)
Organism: Mus musculus (Mouse)
Interaction partners:
- Tumor protein D53
Sequence:
MECRDMELADDYQSPFDFDSGVNKNYLYLSPSGNTSPPGSPTQNVGLLKTEPVAEEGEDAVTMLSAPEALTEEEQEELRRELTKVEEEIQTLSQVLAAKEKHLAELKRKLGISSLQEFKQNIAKGWQDVTATNAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKSKVGGAKPAGGDFGEVLNSTANATSTMTTEPPPEQMTESP
Protein: LIM and senescent cell antigen-like-containing domain protein 4 (LIM and senescent cell antigen-like-containing domain protein 3-like) (P0CW20)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAFSGRARPCIIPENEEIPRAALNTVHEANGTEDERAVSKLQRRHSDVKVYKEFCDFYAKFNMANALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQCFQQFPEGLFYEERT
Protein: Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5) (Q9P2K6)
Organism: Homo sapiens (Human)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19261606}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19261606}. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis.
Interaction partners:
- Cullin-3
- E3 ubiquitin-protein ligase RBX1
- Kelch-like protein 9
- Kelch-like protein 25
- Kelch-like protein 13
- Kelch-like protein 12
- Kelch-like protein 20
- Kelch-like protein 41
- Gigaxonin
- Ectoderm-neural cortex protein 1
Sequence:
MSAEEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQLLLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSWEAFRRFPAFGHNLLVSSLYLPNKAET
Protein: ADP-ribosylation factor like GTPase 13B (A0A096MJR8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
RQNGRNEGDNVRSAKTPSDIRKAYIGKRYLNEKVPEVLHLVLQIHKFLVSLFNLRELCFSHAGLWTRTRLLLSQQPYGSSKPYVTSVPGDRCPLLVFVGTGLANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAVLGYGKKIDKSIKKGLYWLLHIIAKDFDALSERIQKDTTEQRALEEQEKCERAERVRKLREEREQEQTELDGTSGLAEMDSGPVLTNPFQPIAAVIIENEKKQEKEKKKKTAEKDSDVGHPEHKGEQEGAESQNEAGGCLRNPHRDVVNSYKEALSQQLDNEDELDQRVSEPGDNSKKKTKKLRMKRSHRVEPVNTDESAPKSPTPPPPPPPVGWGTPKVTRLPKLEPLGETRHNDFYGKPLPPLAVRQRPNGDAQDMIS
Protein: Ferric citrate uptake sigma factor FecI (P23484)
Organism: Escherichia coli (strain K12)
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the fec genes for iron dicitrate transport (Probable).
Interaction partners:
- Ferric citrate uptake sigma factor regulator FecR
- Fe
- Fe
- Biopolymer transport protein ExbD
- Biopolymer transport protein ExbB
- Ferrichrome outer membrane transporter/phage receptor
- Fe
- RNA polymerase sigma-54 factor
- Anti-sigma-E factor RseA
- Protein TonB
Sequence:
MSDRATTTASLTFESLYGTHHGWLKSWLTRKLQSAFDADDIAQDTFLRVMVSETLSTIRDPRSFLCTIAKRVMVDLFRRNALEKAYLEMLALMPEGGAPSPEERESQLETLQLLDSMLDGLNGKTREAFLLSQLDGLTYSEIAHKLGVSISSVKKYVAKAVEHCLLFRLEYGL
Protein: Sorting nexin-10 (Q9CWT3)
Organism: Mus musculus (Mouse)
Function: Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22174188}. Endosome membrane {ECO:0000269|PubMed:22174188}; Peripheral membrane protein {ECO:0000269|PubMed:22174188}; Cytoplasmic side {ECO:0000269|PubMed:22174188}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=May also localize to nucleus and endoplasmic reticulum.
Interaction partners:
- Vacuolar protein sorting-associated protein 35
- Osteopetrosis-associated transmembrane protein 1
- Pleckstrin homology domain-containing family M member 1
Sequence:
MFPEQQKEEFVSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFTMKTSCVRRRYREFVWLRQRLQSNALLVQLPELPSKNLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDIEACVSGQTKYSVEEAIHKFALMNRRFPEEEEEGKKDADVEYDSESSSSGLGHSSDDSSSHGCKTSPALQES
Protein: Japonicin-1CDYa (B3VZU2)
Organism: Rana dybowskii (Dybovsky's frog) (Korean brown frog)
Function: Antimicrobial peptide. Has low activity against the Gram-positive bacterium S.aureus (MIC>100 uM) and the Gram-negative bacterium E.coli (MIC=25 uM). Lacks hemolytic activity against human erythrocytes.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P32412}.
Interaction partners:
Sequence:
MFTLKKSLLLLFFLGVINVSLCEEERDADEEERRDDPEERDVEVEKRFFPLALLCKVFKKC