wanglab/gogpt-training-data huggingface dataset:
Protein: Adenomatous polyposis coli (P91667)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLEPTLTPDLEEGIAELSLEDVDVDSVPERKPHFLDYDAVPPPDYEEGFGASSGEQLKMDKKYERDGEVSDYELAASGYTKKEFTQDDNTLHFTQSAVGLGSGAVGKKPAAKHFLDENPIPPDYMLAQELREMREHRSLDRNFERQSAQQQQLDELPPRNGGGSPASAGRPSRSKEPSYTLSRFLDGDAPAPAPRLPKGAAWTTSFDERYTSSAVEATLGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSGCMPLLVQMMHAPDNDQEVRKCAEQALHNVVHSHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQSGGEAIADDSDRHPLAAISSLMKVSFDEEHRHAMCELGALHAIPNLVHLDHAVHGPKPEDQCCNSLRRYALMALTNLTFGDENNKALLCGQKQFMEALVAQLDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENTLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAVCEPYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAVPMLRSLIHSKHAMISEGSSSALKNLLNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKALQQELGERHTAETCDNLDTGGKLDKERASSSSRRHPAPRLTRSAMLTKSESRDSVYSAKSDCAYDHLIRSASASDAHRKVKPKITDFDLEMEQDTEATEEQPIDYSVKYSENATKTSTYQETDLDQPTDFSLRYAENQIESDLDISGPAGGQKSTITPPAETVPEKSEGQEILLILDDSVKCYQTEDTPYVISNAASVTDLRVAAKADREAEVKPEVREVTSKEGAPKKLPKLSQCGSGSYTPEKPINYCEEGTPGYFSRYDSLSSLDESGKANQAIVGTDADIKPKLEKQEEQESQPAEQVLTKPPTQANSALETPLMFSRRSSMDSLVHDPDVDVANCDDKSSVVSDFSRLASGVISPSEIPDSPTQSMPQSPRRNSVAGSGQNVDSPPVVIPASLQPLRSVFEDDLSSFNVEHTPAQFSTATSLSNLSIVDDEKAPAVWTEDNEDELLLANCINMGMQRKPTEAVKSTVVNSEVDVAEETIRSYCTEDTPALLSKVPSNTNLSVISMSSTDPKDATAGQAQMYAHQLSDDVSSNASDCGGASGHLLQQCIRDGMKKPLGEATSDPIAMLRRGGNELPGYLPSADEMNKFLVEDSPCNFSVVSGLSNLTVGSSLVGPAVQLKETEPSSADQNPEMKRSLANRSKSRRPPHWQDDSLSSLSIDSEDDTNLLSQAIAAGCNRPKSNLGFSSNGKRSSSLSSSQPIAINAATSASSLNSAMTVRKSQQQESYSSVDSSDSNDNQSKSLFELCILKGMYKTKEPGARAQQMQEQPIVGSSSVQSNPSLKQFDSLPVQLPSSGQVKRQRHHHHHHHHRERERERKDEKLLQECINTGISKKINAVPKNVLATSAAALEPCHPMAATTSASALSTAAPDVEQKAHATSNPQQQSSTHPSSHILPNPIDAIATVTDTARSPAAPNQGNGNASQNGLETATGSKDLDSEDRSSDESNQSFIMETMVRLDSALNETCISGASEKHKDPDLMLKSVERLTMEFVTSAEQLRSSSHNHSSSNSHKNNSSNNTWNESTCPNDVSFPSVSQTAPVLASLSLDEDATEARSLHELIEITPTNEQQPESLEGETDTLVNGHADSYSGSSGGLNFQLGGQVQNAGVRLEPQRLLFNGTSASIMTNSTMIAFEARALAENLLQPAATDDDTTEMTFSLNSLDLDNIRPPSGMESLNSCYQDHSQPSSLRQAMPSKSPRFARKMFPANLVARRALGHLAGSAESVNSSCNLLDNIKPPSLMDELLDSMISVDSIQSEVADGEQDCSMATTISVSNYETAACDDQTMTVLQSCFDEDEDATMNDYSSAESTPKHGSTPSPNRRSLTPKDKRRLTKDRFKTYTIATSCEMEAPEANETLQIEIVEAAVPVATPSPRANGRRRGSAERYKTQLIECPLALIQPQPDDCPSEQLSSIRAMMQQFTFITDINIGHSQETCESTDHPEDAGESPECDQNSETESCDGQEPDHLPPPPSIVDLRTSVVKPTTLEPATAVKLVRGRKKPAYVSPYSMQSQRNSNNAAPSKKKTLSPTIAKRSLVPGGSGVRLPAKKKPTPPPEPAPARLERQGTFVKDEPTNSNVQVPVVETKPAQTSPTHRASKLPTKKGTASGGSPSKAGSPKRIPLAPARRMTPQRANTSLRLAAGKSPAASRVVSGRVSSTTPPSRSNSNLNGSSAAAAAAAKINQAQSRIANIWKRVDEAKTKQSSSNLRTQKTKSSNMLNANGTKPTLLRSSTFDNTPSTAGGVKSKLPVVGARK
Protein: Delta-6 fatty acyl desaturase (D2KE02)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGGGGQQTESSEPAKGGVVGPGGGRGGRGGSAVYTWEEVQRHSHRGDQWLVIDRKVYNITQWVKRHPGGIRVISHFAGEDATDAFSAFHPDPNFVRKFLKPLLIGELAPTEPSQDQGKNAALVQDFQALRDHVESEGLLRARLLFFSLYLGHILLLEALALGLLWVWGTSWSLTLLCSLMLATSQSQAGWLQHDFGHLSVFKKSSWNHVLQKFVIGHLKGASANWWNHRHFQHHAKPNVFSKDPDVNSLHVFVLGDKQPVEYGIKKLKYMPYHHQHQYFFLIGPPLLIPVYFHIQILRTMFLRQDWVDLAWSMSFYLRFFCCYYPFFGFFGSVALISFVRFLESHWFVWVTQMNHLPMEMDHERHQDWLTMQLSATCNIEQSTFNDWFSGHLNFQIEHHLFPTMPRHNYHLVAPLVRALCEKHGVPYQVKTMQQGLTDVVRSLKKSGDLWLDAYLHK
Protein: Javelin-like, isoform C (Javelin-like, isoform E) (LP10202p) (Q6NNB4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MECLPMSSAAHHPHLMAGASAVGAVSASPTATVVVGATYPHHLHHHHLSHHTPYSNSYGSHHIHSEQTKSLQELQHEVGALLEFRDLVIETFPDLKHKMASMSATPSTPTSSVGAIGGSHSVGGGSSSLATRREWEPGIRMKRKQSHKEPSTSSAAAAPSSGAEASSSSLTRSRSNSHSGKKEPKSGENNNGSVVQDSGFSTETSSSKEGHSASSTNGAMTVAIAANRLSCAESDDELLNLLDVIHRKSNRLREEVEHLQSYERQHGDAQKTGGEGQGASKEGMTAQQFREQVERLNREDIKQLRKERDRLLDKLAEMEAETLTGRIKAAKMSDQVEELVGVKKDLEEQLKLAMAQKLELSSRVQQLQQQQQSKSSSSGSQSDYSSQRNFLSSATTVLSNGSRPSSNVISNNTFQPVVLDQPAQEAFHQSPGSDIPLRKQQQQSLGRLDGIVSTPGTRNSKCRLTDSKRFAAILLETNVLELQRHLLTLTVQNQVLAQKLESSSKSKTLLAKRLDKNSEEFEHLRYQLEEKNIELEGTKAQLRLVESRLQASNSTSNSYLHSSQHDYETNRSSASTTLMLSRRGVSDSVDSTSTAMPAPPVTQISTPSMKAMVPLAMDELQQHSSSTESAHEHENQGLQTPNSTSSPLSKTIINASPCPVGSSTPSNIAARVMSISVGGVSPFEAMTPPPRQNAFRKFGSASKPSKIPLPGSKAAAYFSGKPPTGRPSTAGRSPPSANNSSSTSYGSKSSLSRSTGNLQSLRRAETSASNHSLSTNTSRSSTSSSIPLATTPYSSGSTGNRSQPTAATTPSPRVLQNSPLPKLKRDTISSRVRHLDSLSRAQQTPEGLKGTTTNSTSIAAQLSSTLRKDLQLSGNGTGAPYNQHHLNHRRSGHSPASNSSGSGVSRRYSSASTGGSGGRAIGRDQGEPTTPTSSYGGDSDSGKIQATYPNKRQATLRK
Protein: Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-like protein) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (RACK1) (P38011)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, RACK1 serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Involved in the negative regulation of translation of a specific subset of proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein eS19A
- Large ribosomal subunit protein uL30A
- Eukaryotic translation initiation factor 3 subunit B
- Small ribosomal subunit protein uS4B
- Small ribosomal subunit protein eS12
- Large ribosomal subunit protein eL15A
- Small ribosomal subunit protein uS12A
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS13A
- Large ribosomal subunit protein eL38
Sequence:
MASNEVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN
Protein: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit (Q91V89)
Organism: Mus musculus (Mouse)
Interaction partners:
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Shugoshin 1
- Meiotic recombination protein REC8 homolog
- Apoptosis regulator Bcl-2
- D
- Protein phosphatase 1 regulatory subunit 1A
- Ryanodine receptor 2
Sequence:
MSYKLKKDKEPSKLAKGTAKPSSSSKDGGGENTDEAQPQPQSQSPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSFPFNLNKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKCKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKVFLVRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARILPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKDKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL
Protein: RNase P protein subunit (Q54HY6)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- RNase P protein subunit
- RNase P protein subunit
- Ribonuclease P protein subunit drpp30
- RNase P protein subunit
- Probable ribonuclease P/MRP protein subunit POP5
- Ribonuclease P protein subunit p29
Sequence:
MSDTEFEENETNIDETEEDYNEDDENLMSDHKEFLLLNDPTKYVYMRRVVQRPYAKKNEIYLSNNGKFLYYVKRAKNLLFNQREKEIIIHGLGAAISLAVELSLYLQKDIEGLTLSTTTSSEEIIDQYDPLVNDLEPVLKIRHASAIHIKIINDGSSTNPNTTNSTTTTTTTTLTPINFRTTSKKSNSQSKENKKLLKRQELDKKVEQAKSQQKQQREQQQLKVQETC
Protein: Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8) (Q14296)
Organism: Homo sapiens (Human)
Function: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.
Subcellular location: [Isoform 4]: Mitochondrion matrix {ECO:0000269|PubMed:25704814}. Note=Colocalizes with mitochondrial RNA granules. {ECO:0000269|PubMed:25704814}.
Interaction partners:
- FAST kinase domain-containing protein 2
- Cytotoxic granule associated RNA binding protein TIA1
- FAST kinase domain-containing protein 1
- Nucleolysin TIAR
Sequence:
MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQPCCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG
Protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1) (Q8VHH5)
Organism: Mus musculus (Mouse)
Function: GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.
Subcellular location: Cytoplasm. Note=Upon oxidative stress, translocates to PML nuclear bodies. {ECO:0000250}.
Interaction partners:
- Protein TANC1
Sequence:
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGSSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSRKGADLDREKKAAECRVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPTTAPGTSPRANGLAMERSNTQLGGATGAPHSASSTSLHSERPHSSAWAGSRPGPEGLHQRSCSVSSTDQWSEAAALPASMQHPASGPAESLSSSPKLEPPPSPHSNRKKHRGKKSTGTPRPDGPSSAAEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNTALAVQAVRTVRGNSLCIDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSIL
Protein: Fibrinogen-like protein 1-like protein (Cytidine deaminase) (CDD) (O93526)
Organism: Gallus gallus (Chicken)
Function: Shows a cytidine deaminase activity on 2'-deoxycytidine (in vitro), however shows no RNA editing activity (in vitro).
Interaction partners:
- Aminopeptidase like 1
- Chymotrypsin C
- Neutral ceramidase.
- Hydroxyacylglutathione hydrolase, mitochondrial
Sequence:
MGLQAGTRQLHGNLILLPVAVVMLLLCTSPVCATASVGLPADCSRLTSSSPSGVYVIQPAQSPPRVVWCDMDTEGKGWTVVQRNTYSTEITWKESWTTYKYGFGNVQGDHWLGTEYLHLLTQQGTYKVRFVVRDKANVTHYAEYDIFRVESESSGYPLRLGRLLSSGKDYLTSYYSSYGGIHDNMKFSTVDKDQDQHSGNCASSYGGWWYDRCQNVLLNGKKYILWPEICPRVTACRPSSWSNPPMCADCARGWGSATIPSRSPSLPSPITATHTVRNQLQ
Protein: Protein root UVB sensitive 1, chloroplastic (Protein WEAK AUXIN RESPONSE 3) (Q7X6P3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in a root UV-B sensing pathway and in the protection against the hypersensitivity to very low-fluence-rate (VLF) UV-B. RSU1 and RUS2 are probably both negative modulators of the same UV-B perception pathway, which when overstimulated in the roots causes a block to postgermination development. Required for polar auxin transport by maintaining the proper levels of auxin transporters AUX1 (AC Q96247) and PIN proteins on the plasma membrane.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:23580592}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Aspartate aminotransferase, cytoplasmic isozyme 1
- Uncharacterized protein At5g13720)
Sequence:
MSCSYLLSGDASVVASRRWSDVSSRQRLFLPRQSLRQPSGSSFSRCVRLVANVNDHFSKQSLATRNCLASVFSADLGGSNGNNDNGNGGGGGGDGGGDNSDDSSFDLRYLCFLLLGLSCFFHFRLSAASAIAKDQNSDSNGDAVKETVWEVRGSKRKRLVPDFVKDEFVSEESAFELSSSLTPENLLAQCRNLLTQFLLPEGFPNSVTSDYLDYSLWRGVQGIASQISGVLATQSLLYAVGLGKGAIPTAAAINWVLKDGIGYLSKIMLSKYGRHFDVHPKGWRLFADLLENAAFGMEMLTPVFPQFFVMIGAAAGAGRSAAALIQAATRSCFNAGFASQRNFAEVIAKGEAQGMVSKSVGILLGIVVANCIGTSTSLALAAFGVVTTIHMYTNLKSYQCIQLRTLNPYRASLVFSEYLISGQAPLIKEVNDEEPLFPTVRFSNMKSPEKLQDFVLSSEAKAAAADIEERLQLGSKLSDVIHNKEEAIALFDLYRNEGYILTEHKGRFCVMLKESSTPQDMLRSLFQVNYLYWLEKNAGIEPASTYSDCKPGGRLHISLDYVRREFEHAKEDSESVGWVTEGLIARPLPTRIRLGHDRELLLSSPNSS
Protein: Probable transcriptional regulatory protein (O53623)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable oxidoreductase
- Probable membrane protein
- Probable transport protein MmpL6
- Transcriptional repressor Mce3R
Sequence:
MEIKRRTQEERSAATREALITGARKLWGLRGYAEVGTPEIATEAGVTRGAMYHQFADKAALFRDVVEVVEQDVMARMATLVAASGAATPADAIRAAVDAWLEVSGDPEVRQLILLDAPVVLGWAGFRDVAQRYSLGMTEQLITEAIRAGQLARQPVRPLAQVLIGALDEAAMFIATADDPKRARRETRQVLRRLIDGMLNG
Protein: Phosphoglycerate kinase (EC 2.7.2.3) (Q9GPM4)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P00558}.
Interaction partners:
- Triosephosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase
- Probable phosphoglycerate mutase
- Glucose-6-phosphate isomerase
- Cleavage stimulation factor subunit 3
- Peptidase S49 domain-containing protein
- Phosphoglycerate mutase family protein
- Fructose-bisphosphate aldolase
- Transketolase
- Enolase A
Sequence:
MSSNKIGNKLSLDKVDVKGKRVLIRVDYNVPLDKNNNITSTQRIDASIPTLEYCLKNGAKSIVLMSHLGRPDGLVKPEYSLKPVVKVLEDQLKRPIKFLSDCVGEQVEKECANPEEGTVILLENLRFHIEEEGSGVDAEGKKVKANPEKVKEFRESLTKLGDVYVNDAFGTAHRAHSSMVGINLPQKAAGFLMKKELEYFAKALESPSKPFLAILGGAKVSDKIKLIENLLYKVDEMIIGGGMAFTFKKFIDNKEIGSSLFEKTAEQITKDIIAKAAKNNVKLHFPVDYVIADKFDNDANIKTVTQDQGIPEGWMGLDCGPETIKENRDTISRAKTIVWNGPMGVFEKSNFEAGTKAAMDDVVNATTNGAITIIGGGDTATCAAKYNTEDKVSHVSTGGGASLELLEGKELPGVTALSDL
Protein: Protein KHNYN (KH and NYN domain-containing protein) (O15037)
Organism: Homo sapiens (Human)
Interaction partners:
- Ubiquitin-like protein NEDD8
- Zinc finger CCCH-type antiviral protein 1
- E3 ubiquitin/ISG15 ligase TRIM25
Sequence:
MPTWGARPASPDRFAVSAEAENKVREQQPHVERIFSVGVSVLPKDCPDNPHIWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFFLDCLAWSTSAHLVPRAPGSLMISGLTEAFVMAQSRVEELAERLSWDFTPGPSSGASQCTGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGALASWEGRSSALLGAQCQGVRAPPSDGRESLDTGSMGPGDCRGARGDTYAVEKEGGKQGGPREMDWGWKELPGEEAWEREVALRPQSVGGGARESAPLKGKALGKEEIALGGGGFCVHREPPGAHGSCHRAAQSRGASLLQRLHNGNASPPRVPSPPPAPEPPWHCGDRGDCGDRGDVGDRGDKQQGMARGRGPQWKRGARGGNLVTGTQRFKEALQDPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDITVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYDDRFMVKLAEETDGIIVSNDQFRDLAEESEKWMAIIRERLLPFTFVGNLFMVPDDPLGRNGPTLDEFLKKPARTQGSSKAQHPSRGFAEHGKQQQGREEEKGSGGIRKTRETERLRRQLLEVFWGQDHKVDFILQREPYCRDINQLSEALLSLNF
Protein: PSI domain-containing protein (Q389P6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSLWLTLFSVPFLLVRVASADHKRSILKDDVWLEMPTPSRTEGSNVVWPVVRGLVALNGSAGVGQVVNRLSSNESLSVGGLVGCGDGYCPSFAPICCGGPAYYYCVSGGSKCCGFPGRVVGSCGQSEECCADERNVTCCEAGSYCKVDGSDLACASDTCSHRLTVDECLSQNDGCGWCCEEHRCVRNTSGCSKGGRPIAVGETCPSRCHYADTCGLCLASGDAASGLEDCMWCCGSQSCIPSSEGDSCQNLQGIVSPGFCSACLSNGEGVGPTFVGSLQQMLALFSSFVFMIGIISCVWVSRACATYRDNTIVANGMRQVEVAAHYAVRRHGFIADGLSAEGGSSGCCPLLRCICCFCTTRRSDPSKQIQEEGGDGPCLSGEFYCAGCELALRPRSLLSLVDAVQGSRPPGERGICDDSDYHAEDEGIIVLLPCGHFYCYACLNIKKKRTISPRRLPKQTCSAAASDSQVRAEEALQSVSSADGEHAGNPSGAHVDADNREAGAAEAQESSCCGCLLCPFGKNSKERVAGEPKGVVDIGKLAMKKIKRKCPKCRRTVTDVLLPHNIIHL
Protein: tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase) (O60294)
Organism: Homo sapiens (Human)
Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
Interaction partners:
- tRNA wybutosine-synthesizing protein 5
- tRNA wybutosine-synthesizing protein 2 homolog
- tRNA wybutosine-synthesizing protein 3 homolog
- S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1
- tRNA
- Zinc finger protein 302
Sequence:
MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAPLIHRGYYVRARAVRHCVRAFLEQIGAPQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVARRKAERIGETPELCALTGPFERGEPASALCFESADYCILGLDLRQLQRVEEALGAAGLDAASPTLLLAEAVLTYLEPESAAALIAWAAQRFPNALFVVYEQMRPQDAFGQFMLQHFRQLNSPLHGLERFPDVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWHLKCAHYFILAASRGDTLSHTLVFPSSEAFPRVNPASPSGVFPASVVSSEGQVPNLKRYGHASVFLSPDVILSAGGFGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGVQWDGRLYHTMTRLSESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGRKDDSTLCCWRHSTTEVSCQNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSHTAHVLNGKLLLVGGIWIHSSSFPGVTVINLTTGLSSEYQIDTTYVPWPLMLHNHTSILLPEEQQLLLLGGGGNCFSFGTYFNPHTVTLDLSSLSAGQ
Protein: Phospholipid-transporting ATPase DNF1 (EC 7.6.2.1) (Flippase DNF1) (P32660)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12631737, ECO:0000269|PubMed:18199685, ECO:0000269|PubMed:22308393, ECO:0000269|PubMed:27235400, ECO:0000269|PubMed:33060204, ECO:0000269|PubMed:33320091}; Multi-pass membrane protein {ECO:0000269|PubMed:18199685}. Endosome membrane {ECO:0000269|PubMed:18199685}; Multi-pass membrane protein {ECO:0000269|PubMed:18199685}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18199685}; Multi-pass membrane protein {ECO:0000269|PubMed:18199685}. Cell septum {ECO:0000269|PubMed:22308393}. Bud {ECO:0000269|PubMed:22308393}.
Interaction partners:
- Phospholipid-transporting ATPase accessory subunit LEM3
- Phospholipid-transporting ATPase accessory subunit CDC50
- Phospholipid-transporting ATPase DNF2
- Flippase kinase 1
- Phospholipid-transporting ATPase DRS2
- Serine/threonine-protein kinase KIN82
- Probable phospholipid-transporting ATPase DNF3
- Phospholipid-transporting ATPase NEO1
- Phospholipid-transporting ATPase accessory subunit CRF1
- CDP-diacylglycerol--serine O-phosphatidyltransferase
Sequence:
MSGTFHGDGHAPMSPFEDTFQFEDNSSNEDTHIAPTHFDDGATSNKYSRPQVSFNDETPKNKREDAEEFTFNDDTEYDNHSFQPTPKLNNGSGTFDDVELDNDSGEPHTNYDGMKRFRMGTKRNKKGNPIMGRSKTLKWARKNIPNPFEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKRMQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDCKFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAGSAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRDLKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAALVATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQSGSNSEAILEKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTDVEIVREMWQHGHFDHYPPGYDPTDPNRPKVTKAGQHGEKIIEGIALSDNLGGSNYSRDSVVTEEIPMTFMHGEDGSPSGYQKQETWMTSPKETQDLLQSPQFQQAQTFGRGPSTNVRSSLDRTREQMIATNQLDNRYSVERARTSLDLPGVTNAASLIGTQQNN
Protein: Eig71Ek (L71-11 protein) (Q9VUT3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ecdysone-induced gene 71Ed
Sequence:
MWKIFLLLVLCILQLCHIDAQWSRVYCENIYNDCQRFTSRIGRFDETIDSFNRHCRRERRGRWNSVSRCEMEKATCLLIFRRCDDMSCNNIADVLEL
Protein: Slow myosin heavy chain 1 (Q508P8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGDAVMAEFGSAAPFLRKSDKERLEAQTRIFDMKKECFVPDPEVEYVKASITSRDGDKVTVDTEYGKTLTFKECDVHPQNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYDSSVVKAYRGKKRTEAPPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAVSGKKDAASEKKGTLEDQIIQANPALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLASADIETYLLEKSRVTYQLKAERDYHIFYQILSQKKPELLEMLLITNNPYDYSYISQGETQVASIDDAEELIATDDAFDVLGFTQDEKSGIYKLTGAIMHFGNMKFKQKQREEQAEADGTEDADKVAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNVQQVYYSIGALAKSVYEKMFLWMVVRINQSLDTKQPRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLQACIELIEKPMGIMSILEEECMFPKASDQTFKAKLYDNHLGKNPTFQKPRIVKGRPEAHFALVHYAGTVDYNISNWLVKNKDPLNETVVGLFQKSTVKLLSFLFAGYSGADSAQDSKGGKGGGKKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRILNPSANPEGQFIDNKKAAEKLLGSLDIDHNQYKLGHTKVFFKAGLLGTLEEMRDDRLALIITGIQARARGILSRLEFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKTAETEKEMANMKEEFTKLKEAYAKSEARKKELEEKMVSLLQEKNDLQLAVQSEQDNLVDAEERCEGLIKSKIQLEAKAKELTERLEDEEEMNAELVAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAALDEIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLTQESIMDLENDKQQMEEKLKKKDFEISQLNSKIEDEQALGAQLQKKLKELQARIEELEEELEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEATLQHEATAATLRKKHADSVADLGEQIDNLQRVKQKLEKEKSELKLELDDVVSNMEQIVKSKSNLEKMCRTLEDQMSEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQSYTQQIEDLKRQLEEEVKAKNALAHAVQSARHDSDLLREQFEEEQEAKAELQRSLSKTNSEVAQWRTKYETDAIQRTEELEDAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKVLAEWKQKYEESQTELESAQKESRSLSTELFKLKNSYEEVLDQLETMKRENKNLQEEISDLTEQLGETGKSIHELEKIRKQLEQEKAEIQTALEEAEGSLEHEEGKILRAQLEFNQVKADIERKLSEKDEEMEQAKRNQQRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQLKGLHGHVKDSQMQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERGRKLAEQELMDVSERVQLLHAQNTSLLNQKKKLEGDNTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLEARVRELENEVELEQRKASESVKGVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKSYKRAAEEAEEQANSNLGKFRKLQHELDEAEERADIAESQVNKMRAKSRDSGPKKGHDEG
Protein: Transcription factor Dp-1 (Q5JSB5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003796}.
Interaction partners:
Sequence:
MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQPSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKN
Protein: DNA-binding response regulator (Q88PE9)
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Interaction partners:
- histidine kinase
- PAP2 family protein
- Methyltransferase domain-containing protein
- histidine kinase
- InaA protein
- Sensor protein
- Diacylglycerol kinase
- Sensor protein
- Sensor protein
- Sensor protein
Sequence:
MRILLVEDNRDILANLADYLGMKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGYTLCKRLREDARRDTPVIMLTARDQLDDRLQGFRSGADDYLLKPFALSELAARIEAVLRRAQGGGRRTLQVADLSYDLDTLEVTRQGRLLKLNPVGLKLLAVLMQKSPHVLRREVLEEALWGDDCPDSDSLRSHVHQLRQVIDKPFEKPLLHTVHGVGYRLAEGRDGV