wanglab/gogpt-training-data huggingface dataset:
Protein: B9 domain-containing protein 2 (MKS1-related protein 2) (M9MRD5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:25447994, ECO:0000269|PubMed:27577095, ECO:0000269|PubMed:27646273}. Note=Localizes at the transition zone (TZ), a region between the basal body and the ciliary axoneme (PubMed:27646273). In spermatocytes, localizes in the transition zone and the migrating base of the spermatid ciliary cap (PubMed:25447994, PubMed:27577095). Co-localizes with the tectonic-like complex (PubMed:27646273). {ECO:0000269|PubMed:25447994, ECO:0000269|PubMed:27577095, ECO:0000269|PubMed:27646273}.
Interaction partners:
- B9 domain-containing protein 1
- Tectonic
- Coiled-coil and C2 domain-containing protein 2A
- Tectonic-like complex member Mks1
- GEO07735p1
- Centrosomal protein Cep290
- Transmembrane protein 231
- Reduced mechanoreceptor potential A, isoform B
Sequence:
MAEVHIIGQILKAVDFAEPHLYCKWSLQSGNAWRLVQGEVQGQSHVASHRLQSSSDFAQPLDIHLSTASVQGWPRLLVEVYAVNVLQQSWPVGYGFVHVPSTPGTHRLEIGTWKVAPNGLWQSLRERFGGGGAALSKTDLLYSGVERYKLQTLSSGKVIVELNLIFRKFDEYGVEFK
Protein: Fibroblast growth factor receptor homolog 1 (EC 2.7.10.1) (DmHD-38) (Protein heartless) (Tyrosine kinase 1) (dTk1) (Q07407)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be required for patterning of muscle precursor cells. May be essential for generation of mesodermal and endodermal layers, invaginations of various types of cells and CNS formation.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Fibroblast growth factor
- Stumps, isoform E
- Pyramus
- Thisbe
- E3 ubiquitin-protein ligase CBL
- Epidermal growth factor receptor pathway substrate clone 15, isoform A
- FI19443p1
- Endophilin-A
- Ras-like protein 1
- Fibroblast growth factor receptor homolog 2
Sequence:
MAAAWSWRASHSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSDEEEDETDNLQKWCNY
Protein: SH2 domain-containing protein (Q19672)
Organism: Caenorhabditis elegans
Interaction partners:
- Exonuclease mut-7
- MUTator
- RNA helicase
- DRBM domain-containing protein
- PAP-associated domain-containing protein
- Piwi domain-containing protein
- E3 ubiquitin-protein ligase
- MUTator
- RNA-directed RNA polymerase
- Dicer-related helicase
Sequence:
MHNGYHSYFPPNHYYAQSQPSSSYNPQPQIQQPQTQIYGLVVGYNKYGNRNYLFYTKNIDGFVEISGNIQSLQIGRWLKLTVCQNFVGQYVLDSSNSCGYENWDVLPNHRNSSARFFPKYEANDEGEILITARFDVIVDRKNNLYDFTSYDISYDHIIDDFSLIKSSCQHYDGRSFIVEAQASLAGWVALSVHEDPQKLHTCDAVSRNGYQSLPNPVVDSDVQYLHDTRLLDIMTGNGYVQTPETDVQDQQSSQHQEDVHSQMNSQTSDSYNSSRVVSENREIPPETFRSQSIELNQVDSSLSQTTISSRAAPVIDSNQLSDEDEIDDEDTYGTRGTSNIPMRPFIKDLAPTMLQLLRQDKTDSEKPQSALCTVVQKIDGFAILYTAKRDVINVLLQERSCEGLERSPQLGDVAFFDILPRRIETKDRLIFKIPYTHIAVKKKPDTPDSLLKIDCFKNSVRCFGGVLEMKVKIALSKPELVVEQYHDNTEMNSDHHFYYLKATNGVLVTIPKERLLNHLNSKLSADFDLIAWVVHRKPIGNVSLHIGKGGEAYQQFTNGDIRELPPLSSNQYFMNVRK
Protein: Retinoblastoma-binding protein 5 homolog (Q9VPH8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'.
Subcellular location: Nucleus {ECO:0000269|PubMed:21694722}.
Interaction partners:
- Histone-lysine N-methyltransferase SETD1
- WD repeat-containing protein 82
- Protein dpy-30 homolog
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Histone-lysine N-methyltransferase trr
- PAX-interacting protein 1
- LD02225p
- Histone-lysine N-methyltransferase trithorax
- CXXC-type zinc finger protein 1
- Protein will die slowly
Sequence:
MNLELLESFGQNYPEEFDGSLDCISLAVTCAFNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKYRFPSPVLKVQFDPRNDNRLLVCPMRYAAVLVEVGGTHRCLPLDSDGDLNIVASFDRRGKHIYTGNAKGKILVLDVETFEVVASFRIIVGTSSATAVKSIEFARRGDAFLINTSDRVIRVYDSKEIITLGKDGEPEPIQKLQDLVNKTTWKKCCFSGDGEYICAGSARQHALYIWEKSIGNLVKILHGTKGELLLDVVWHPVRPIIASISSGLVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIADEDKSVDLNADAQQDEEIEVDVQKVEPVAAFCSSDEEGEDENALQFLPMAPEVEDPEDGWTGQDGLEPSAVMLGHMEPHDYEDDIMASKRRRMQLYDVSLPDAPTDETHPLISSKASKDKQQPVGGKKAAGRTKK
Protein: Proteasome assembly chaperone 2 (CD40 ligand-activated specific transcript 3) (Proteasome chaperone homolog 2) (Pba2) (Tumor necrosis factor superfamily member 5-induced protein 1) (Q9EST4)
Organism: Mus musculus (Mouse)
Function: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12147697}.
Interaction partners:
- Proteasome maturation protein
- Proteasome assembly chaperone 1
- Proteasome assembly chaperone 4
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-5
- Proteasome subunit beta type-4
- Proteasome subunit alpha type-3
- Proteasome subunit beta type-2
- Proteasome assembly chaperone 3
- Proteasome subunit beta type-1
Sequence:
MFVPCGESVPDLTNFTLLMPAVSVGNVGQLAIDLIISTLNMCKIGYFYTDCLVPMVGNNPYATEEENSNELSINTEVYSLPSKKLVVLQLRSIFIKYKSKSFCEKLLAWVESSGCARIIVLSSSHSYHRNDAQLRSTPFRYLLTPCLQKSVQNKIKSLNWLEMEKSRCIPEMSDSEFCIRIPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDAVSLVEYLNEWLQIIKPCNDGPMASALPWKIPSSWRLLFGSGLPPALF
Protein: WD repeat-containing protein 41 (Q3UDP0)
Organism: Mus musculus (Mouse)
Function: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (By similarity). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27617292}.
Interaction partners:
- Guanine nucleotide exchange factor C9orf72 homolog
- Guanine nucleotide exchange protein SMCR8
- Ras-related protein Rab-39B
- Ras-related protein Rab-8A
- Autophagy-related protein 101
- RB1-inducible coiled-coil protein 1
- Autophagy-related protein 13
- Serine/threonine-protein kinase ULK1
- Ragulator complex protein LAMTOR1
- TBC1 domain family member 5
Sequence:
MLRWLIGGGREPQGLAEKAALQTIGEDQGQNPYTELLVLEAHRDIVRFLVRLDDFRFASAGDDGIIVVWNAQTGEKLLELRGHTQKITAVIAFPPLDSCEASSQLLLTASADRTVGVWDCDTGRQIQRVTCFQSTVKCLTVLQRLDIWLSGGSDLGVWNRKLDLLCKTSHLSDTGISALVEIPGNCVAAAVGRELIIFRLVTPTEELPEWDIIEVKRLLDHQDNILSLANINDTGFVTGSHVGELLIWDALDWTVQACERTFWSPTAQLDAQQEIKLFQKQNDISINHFTCDEENIFAAVGRGLYVYNLQLKRVIACQKTAHDSNILHIDKLPNRQLISCSEDGAVRMWEVREKQQLAAEPVPTGFFNMWGFGRVNKQASQPVKKQEENVTTCSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILWKNGERESGVRSLKLFQKLEENGDLYPESP
Protein: Sulfite reductase, dissimilatory-type subunit gamma (EC 1.8.1.22) (Desulfoviridin subunit gamma) (Hydrogensulfite reductase subunit gamma) (P45573)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Catalyzes the reduction of sulfite to sulfide. This is the terminal oxidation reaction in sulfate respiration, a process catalyzed by the sulfate-reducing bacteria.
Subcellular location: Cytoplasm.
Interaction partners:
- Sulfite reductase, dissimilatory-type subunit alpha
- Sulfite reductase, dissimilatory-type subunit beta
- Adenylylsulphate reductase, beta subunit
- Reductase, iron-sulfur binding subunit, putative
- Adenylyl-sulphate reductase, alpha subunit
- Nitrate reductase, gamma subunit, putative
- Iron-sulfur cluster-binding protein
- Cytochrome c family protein
- Protein DsvD
Sequence:
MAEVTYKGKSFEVDEDGFLLRFDDWCPEWVEYVKESEGISDISPDHQKIIDFLQDYYKKNGIAPMVRILSKNTGFKLKEVYELFPSGPGKGACKMAGLPKPTGCV
Protein: Probable LRR receptor-like serine/threonine-protein kinase RKF3 (EC 2.7.11.1) (Receptor-like kinase in flowers 3) (P93050)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:15308754}; Single-pass type I membrane protein {ECO:0000269|PubMed:15308754}.
Interaction partners:
- S-locus glycoprotein family protein
Sequence:
MLFLRRIAVVFFVFTSFSAAQNSTCPLDFSVLEPFRRPKPDGATTCQYLLQGLRLLYSHHLRQTGSFLPPPESAASCWAALQSSVAGFLPRFDVRSTCGFQTPWISQGCMDITTRSQFESLIPNSSLATTAMRCNTSLESNTPCASCTQSLSAFQPYLSGPSLGNVSDCASFPSIYAAAFANSLGPTDKGTAKCLFQLDLASPTSSGANKVKVLVSSFSVLLVASVLVITAWFWYCRRKKSKLLKPRDTSLEAGTQSRLDSMSESTTLVKFSFDEIKKATNNFSRHNIIGRGGYGNVFKGALPDGTQVAFKRFKNCSAGGDANFAHEVEVIASIRHVNLLALRGYCTATTPYEGHQRIIVCDLVSNGSLHDHLFGDLEAQLAWPLRQRIALGMARGLAYLHYGAQPSIIHRDIKASNILLDERFEAKVADFGLAKFNPEGMTHMSTRVAGTMGYVAPEYALYGQLTEKSDVYSFGVVLLELLSRRKAIVTDEEGQPVSVADWAWSLVREGQTLDVVEDGMPEKGPPEVLEKYVLIAVLCSHPQLHARPTMDQVVKMLESNEFTVIAIPQRPIPLVACREEIDRSVSSSSGSGKLTSPTGYQAFSFGGDGPSGNTNTT
Protein: Hrp pili protein hrpA (E0SE54)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Interaction partners:
- HrpS type III protein secretion system regulatory protein
Sequence:
MMGLSNAAAMAGMQSLDKTMASTTAMTTAAQEQKMKTDAISSITDGQMDSATKAMNSGQKAAKAIQF
Protein: Centromere protein L (CENP-L) (Interphase centromere complex protein 33) (Q8N0S6)
Organism: Homo sapiens (Human)
Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:16716197}. Chromosome, centromere {ECO:0000269|PubMed:16716197}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Interaction partners:
- Centromere protein N
- Centromere protein I
- Centromere protein M
- Centromere protein O
- Centromere protein H
- Centromere protein Q
- Centromere protein K
- Centromere protein C
- Centromere protein P
- Centromere protein R
Sequence:
MDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQEDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFNIKVIFSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVATTEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE
Protein: Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) (P26638)
Organism: Mus musculus (Mouse)
Function: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P49591}. Nucleus {ECO:0000250|UniProtKB:P49591}. Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. {ECO:0000250|UniProtKB:P49591}.
Interaction partners:
- L-seryl-tRNA
- Glycine--tRNA ligase
- Tyrosine--tRNA ligase, cytoplasmic
- Leucine--tRNA ligase, cytoplasmic
- Bifunctional glutamate/proline--tRNA ligase
- Serine--tRNA ligase, mitochondrial
- GTP-binding protein Rheb
- Probable arginine--tRNA ligase, mitochondrial
- Cysteine--tRNA ligase, cytoplasmic
- O-phosphoseryl-tRNA
Sequence:
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEAVGDDESVPENVLNFDDLTADALAALKVSQIKKVRLLIDEAIQKCDGERVKLEAERFENLREIGNLLHPSVPISNDEDADNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGPLVFLEQALIQYALRTLGSRGYTPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFDEMIATAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQAEKGIAVPEKLREFMPPGLQELIPFVKPAPIDQEPSKKQKKQHEGSKKKAKEVPLENQLQSMEVTEA
Protein: CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Q5RI33)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- CCN family member 3
- Decorin
- Thrombospondin-1
- Thrombospondin 1a.
- Matrix metallopeptidase 9.
- non-specific serine/threonine protein kinase
- Plasminogen activator inhibitor 1
- WW domain-containing transcription regulator 1
- Endothelin 1.
- TEA domain family member 1a.
Sequence:
MFSGMTQSVIALLFLTFLRWAVAQECSGQCHCPEVPPQCSPGVSLVLDTCGCCRVCAKQLGELCTERDVCDPHKGLYCDYGSPSNRRIGVCTARDGATCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCGMDIRLPSPDCPMPRRVKVPGKCCEEWVCDSPRQNTFVGSALAAYREEETYGPDPSMMRENCLVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESHLEEKIRKGKKCIRTPRVSKPMKFEISGCTTTKSYRPKFCGVCTDGRCCTPHRTATLPMEFKCPDGQVMKKQMMFIKTCACHYNCPGENDIFESMYYKKMVGDMA
Protein: Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) (A0A0S2Z381)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004296}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004296}; Extracellular side {ECO:0000256|ARBA:ARBA00004296}. Cytoplasmic vesicle lumen {ECO:0000256|ARBA:ARBA00004321}.
Interaction partners:
Sequence:
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL
Protein: Recombination-promoting nuclease RpnB (EC 3.1.21.-) (P77768)
Organism: Escherichia coli (strain K12)
Function: A low activity DNA endonuclease yielding 3'-hydroxyl ends (Probable). Upon expression enhances RecA-independent DNA recombination 19-fold, concomitantly reducing viability by 98% and inducing DNA damage as measured by induction of the SOS repair response.
Interaction partners:
- Uncharacterized protein YcdU
Sequence:
MTISTTSTPHDAVFKSFLRHPDTARDFIDIHLPAPLRKLCDLTTLKLEPNSFIDEDLRQYYSDLLWSVKTQEGVGYIYVVIEHQSKPEELMAFRMMRYSIAAMQNHLDAGYKELPLVLPMLFYHGCRSPYPYSLCWLDEFAEPAIARKIYSSAFPLVDITVVPDDEIMQHRKMALLELIQKHIRQRDLLGLVDQIVSLLVTGNTNDRQLKALFNYVLQTGDAQRFRAFIGEIAERAPQEKEKLMTIADRLREEGAMQGKHEEALRIAQEMLDRGLDRELVMMVTRLSPDDLIAQSH
Protein: Arachidonate 5-lipoxygenase-activating protein (FLAP) (MK-886-binding protein) (P20291)
Organism: Rattus norvegicus (Rat)
Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity).
Subcellular location: Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Polyunsaturated fatty acid 5-lipoxygenase
- Leukotriene A-4 hydrolase
Sequence:
MDQEAVGNVVLLAIVTLISVVQNAFFAHKVELESKAQSGRSFQRTGTLAFERVYTANQNCVDAYPTFLVVLWTAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSLAGILNHYLIFFFGSDFENYIRTITTTISPLLLIP
Protein: Stability determinant domain-containing protein (Q8XAD5)
Organism: Escherichia coli O157:H7
Interaction partners:
- Type II toxin-antitoxin system RelE/ParE family toxin
- Phage repressor protein CI
- Phage repressor protein CI
- Ribonuclease I
Sequence:
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Protein: Chaperonin GroEL (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin-60) (Cpn60) (P0A335)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00600}.
Interaction partners:
Sequence:
MSKEIKFSSDARSAMVRGVDILADTVKVTLGPKGRNVVLEKSFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGIKNVTAGANPIGIRRGIETAVAAAVEALKNNAIPVANKEAIAQVAAVSSRSEKVGEYISEAMEKVGKDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDSEKMVADLENPYILITDKKISNIQEILPLLESILQSNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATIEALGQAARVTVDKDSTVIVEGAGNPEAISHRVAVIKSQIETTTSEFDREKLQERLAKLSGGVAVIKVGAATETELKEMKLRIEDALNATRAAVEEGIVAGGGTALANVIPAVATLELTGDEATGRNIVLRALEEPVRQIAHNAGFEGSIVIDRLKNAELGIGFNAATGEWVNMIDQGIIDPVKVSRSALQNAASVASLILTTEAVVANKPEPVAPAPAMDPSMMGGMM
Protein: Ckap5 protein (Q32Q01)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
VRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDISTSIQALTQIDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYSTHMADEKLDKDEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDTDIEPFLKNSSQFFQSYVERGLRVIEMERESKGRIPTSAGISPQMEVTCVPTPTSTVSSLGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAIPPVASSTDMLHSKLSQLRESREQHQHSDLDSNQTHSAGTMTSSSSTANIDDLKKRLERIKSSRK
Protein: VQ motif-containing protein (Q9LES0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Calcium-binding protein KRP1
- At2g22880
- At5g46780
- VQ motif-containing protein 11
- F16F4.1 protein
- VQ motif-containing protein
- At1g32610
- VQ motif-containing protein
- VQ motif-containing protein
- VQ motif-containing protein 33
Sequence:
MASSEGLASVDPWSFRQNFNIDSWLLSDSFSHDSDILAKALHRSISTSTESSPLSPSSFFDSSTAAVDFSPPQTLSNVSFGSDPEIPAASALGLGKRKRGPGVSGGKQTKRRSRVSNKKSQTTFITADAANFRQMVQQVTGAKFLGSSNSIFAPIVKPEPHRLASRLPPSCGNLDRSSAVPTLDTSSFLSNHHQENIITDLGAPTGSFHHQSSAGTTTANVGGGSSAVELDSYPSFPTLESWKVM
Protein: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) (Q43359)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
MAKIKIGINGFGRIGRLVARVALQSDDVELVAVNDPFISTDYMTYMFKYDTVHGQWKHHEVKVKDSKTLLFGEKEVAVFGCRNPEEIPWGSVGAEYVVESTGVFTDQEKAAAHLKGGAKKVVISAPSKDAPMFVVGVNEKEYKSDINIVSNACCTTNCLAPLAKVINDKFGIVEGLMTTVHAITATQKTVDGPSSKDWRGGRAASFNIIPSSTGAAKAVGKVLPVLNGKLTGMSFRVPTVDVSVVDLTVRLEKSATYDEIKAAVKAEAEGSLKGILGYVEEDLVSTDFQGDSRSSIFDAKAGIALNGNFVKLVSWYDNEWGYSTRVVDLIRHMNSTN
Protein: At2g30700/T11J7.9 (Bacterial trigger factor) (Expressed protein) (Q945Q5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- At1g64880
- Small ribosomal subunit protein uS9c
- Large ribosomal subunit protein uL13c
- Small ribosomal subunit protein uS9m
- Trigger factor-like protein TIG, Chloroplastic
- Large ribosomal subunit protein uL5c
- Small ribosomal subunit protein uS14m
- Large ribosomal subunit protein mL46
- Small ribosomal subunit protein mS29
Sequence:
MQTIIHSLSFCSFNSTTINPKPRFQFSSFLTLPPTYSVQQKLCTRATNRQFVAVCAAPSDVETSSKDESVLITKVETETSNEVKVHVQVSGEKTQTVFNHVFEKMVAAAQPIPGFRRVKGGKTPNIPKDVLLEILGYSKVYKQVIKKLINSAIEDYVKQEDLKVGKELTVVQSYEDLEETFEPGESFSFDATIKLQEAS
Protein: Probable 3',5'-cyclic phosphodiesterase pde-3 (EC 3.1.4.17) (Q8I0P7)
Organism: Caenorhabditis elegans
Interaction partners:
- Inosine triphosphate pyrophosphatase
- AMP deaminase
- adenylate cyclase
- Putative cytosolic 5'-nucleotidase 3
- 5'-nucleotidase
- Adenine phosphoribosyltransferase
- Adenosine kinase
- Adenylate kinase
- Probable adenylate kinase isoenzyme ZK673.2
- Adenylate kinase isoenzyme 1
Sequence:
MSPGPPAVGGVSPPVMVPGSAPPFQPTHQYFQHHYHQTPPGKLRDRSPRLSAEMRKNRDTATSSPASSGVSIQQRRGSTTQNSGVGSIGLPVLGGRGRGVMSDGHMQRTFHEAMRQRRTSLPANSLSLNGAKVTGSSLSEAKGLIADMLMNKELPGNVASCLRAVTMLLEQRPLPLNGLLNDFGLPSVVENPYGGESMVVGASKPRISNITFSTVTSATGLPTVPAEPNKARSSSYWKTEASPSNNNEHETPVDLLRKISVSRKESGTHVDTVVTTIDGQRYDTRELDTDPDLAETAVWSFPIFQMSRKHPQTILSRLTYNIFQQAELFRIFKVSPIKFFNFFHALEKGYWEIPYHNRIHAADVLHGCYYLSAHPVRSTFLTPKTPDSVLTPPHPHHQHSSIMSQLSTLELMALFTAAAMHDYDHPGRTNAFLVQVEDKKAILYNDRSVLENHHAAESWKLLNKPENHFIENLDPAEMKRFRYLVLEYILATDLKQHFEIIMTFTERLTEIDVQVETDRLLIGKLLIKMADINSPTKPYGLHRQWTDRICEEFYEQGDDERRRGLPITPYMDRGDAQVAKLQDSFIAHVVSPLATAMNECGLLPILPGLDTSELIINMEHNHRKWKEQIELENGGSYEAQITCNGGTAVNGVIEEESASTSDSPDPRRDSPLDSDLSQ
Protein: Parathyroid hormone-related protein (PTH-rP) (PTHrP) (Parathyroid hormone-like protein) (PLP) [Cleaved into: Osteostatin] (P13085)
Organism: Rattus norvegicus (Rat)
Function: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MLRRLVQQWSVLVFLLSYSVPSRGRSVEGLGRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPAPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRREQEKKKRRTRSAWPGTTGSGLLEDPQPHTSPTSTSLEPSSRTH