wanglab/gogpt-training-data huggingface dataset:
Protein: Tax1-binding protein 1 homolog (Q3UKC1)
Organism: Mus musculus (Mouse)
Function: Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation. Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (By similarity). Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways. Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (By similarity). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86VP1}. Mitochondrion {ECO:0000250|UniProtKB:Q86VP1}. Preautophagosomal structure {ECO:0000250|UniProtKB:Q86VP1}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q86VP1}.
Interaction partners:
- RING finger protein 11
- Gamma-aminobutyric acid receptor-associated protein
- Tumor necrosis factor alpha-induced protein 3
- Contactin-2
- Ubiquitin-conjugating enzyme E2 N
- TNF receptor-associated factor 6
- Gamma-aminobutyric acid receptor-associated protein-like 2
- E3 ubiquitin-protein ligase Itchy
- Gamma-aminobutyric acid receptor-associated protein-like 1
- Sequestosome-1
Sequence:
MTSFQEVQLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHSKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRAASPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTLKEKEELLKLIAVLEKETAQLREQVGRMERELSQEKGRCEQLQAEQKGLLEVSQSLRVENEEFMKRYSDATAKVQQLEEDIVSVTHKAIEKETDLDSLKDKLRKAQHEREQLECQLQTEKDEKELYKVHLKNTEIENTKLVSEIQTLKNLDGNKESMITHFKEEISKLQSCLADKENLYRALLLTTSNKEDTLFLKEQLRKAEEQVQATRQELIFLTKELSDAVNVRDKTMADLHTARLENERVKKQLADTLAELQLHAVKKDQEKTDTLEHELRREVEDLKLRLQMAADHYREKFKECQRLQKQINKLSDQAASTNSVFTKKMGSQQKVNDASINTDPAASTSASAVDVKPAASCAETGFDMSTKDHVCEMTKEIAEKIEKYNKCKQLLQDEKTKCNKYAEELAKMELKWKEQVKIAENVKLELAEVEDNYKVQLAEKEKEINGLASYLENLSREKELTKSLEDQKGRKLEGQSPQQVSRCLNTCSEQNGLLPPLSSAQPVLQYGNPYSAQETRDGADGAFYPDEIQRPPVRVPSWEDNVVCSQPARNLSRPDGLEDPEDSREDENVPIPPDPANQHLRSHGAGFCFDSSFDVHKKCPLCELMFPPNYDQTKFEEHVESHWKVCPMCSEQFPPDYDQQGFERHVQTHFDQNVLNFD
Protein: Nanos homolog 1 (E7FDB3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May act as a translational repressor which regulates translation of specific mRNAs.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8WY41}. Cytoplasm {ECO:0000250|UniProtKB:Q8WY41}.
Interaction partners:
- Pumilio RNA-binding family member 2.
- Dead end protein 1
- CCR4-NOT transcription complex subunit 1
- Pumilio homolog 1
- Tudor domain-containing protein 7A
- Deleted in azoospermia-like
- Piwi-like protein 2
- Piwi-like protein 1
- Bucky ball
Sequence:
MDFLNHNYLSARASYDYTFNFWNDYLGLSTLVTKNSKHSVPQNPNSITESLKATLGLDDSPPCPCVMGEGDSGGHLDSCCCPPPASISILDLKERFSILSPFQNQNQGSLLSSSQEREIGIGGGFAGFDLFGVERKMRKPAARNKQEPKICVFCRNNGAPEEVYGSHVLKTPDGRVVCPILRAYTCPLCSANGDNAHTIKYCPLSKDQPAQRVLKGGRAVGGKRVKIF
Protein: Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (Fas antigen ligand) (Q53ZZ1)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}. Cytoplasmic vesicle lumen {ECO:0000256|ARBA:ARBA00004321}. Lysosome lumen {ECO:0000256|ARBA:ARBA00004227}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL
Protein: Cytochrome P450 family protein (Cytochrome P450, family 94, subfamily D, polypeptide 1) (F12K21.15) (Q9LNL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytochrome P450, family 71, subfamily B, polypeptide 32
- Auxin-responsive endogenous peptide 1
- Uncharacterized protein At5g08430
- T-complex protein 1 subunit theta
- ABC transporter D family member 1
Sequence:
MALLIFIFLLCFPISIFFIFFTKKSSSEFGFKSYPIVGSFPGLVNNRHRFLDWTVETLSRCPTQTAIFRRPGKQQLIMTANPSNVEYMLKTKFESFPKGQQFTSVLEDFLGHGIFNSDGDMWWKQRKTASYEFSTKSLRDFVMSNVTVEINTRLVPVLVEAATTGKLIDLQDILERFAFDNICKLAFNVDCACLGHDGAVGVNFMRAFETAATIISQRFRSVASCAWRIKKKLNIGSERVLRESIATVHKFADEIVRNRIDQGRSSDHKEDLLSRFISKEEMNSPEILRDIVISFILAGRDTTSSALSWFFWLLSMHPEVEDKILQELNSIRARTGKRIGEVYGFEHLKMMNYLHAAITESLRLYPPVPVDIKSCAEDNVLPDGTFVGKGWAITYNIFAMGRMESIWGKDCDRFDPERWIDETNGCFRGEDPSKFPAFHAGPRMCVGKDMAYIQMKSIVAAVLERFVVEVPGKERPEILLSMTLRIKGGLFARVQERS
Protein: Transcription factor EB (E7FEM8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSRIGLRLQLMRDQMQQEEQRERQQQQAVSMHYMQHRMPGPPEPTPAISAPTHFQGPMQVPVEVLKVQTHLENPTDYHIRQSQRQQVKEYLSTTYATKQAVHAVTSLVQPSPPPMVQAQTGSAPPNMHSPCMRTEQLMNSAGNSAPNSPMAMLNISSSHENEMDDVIDNIISLQSSYDDIQAYNDPVVQMPNTLPLSSSHLDVYTGPGMSGSAIAMTSNSCPANLAIKRELSEARAMAKERQKKDNHNLIERRRRFNINDRIKELGTMIPKTNDLDVRWNKGTILRASVDYIKRMQKDVQRTREVENNFRRMEMANKQLWLRIQELERQAQIHGLPSNSPSGLTNTDHQNPFIKQESSPEENHLQHQSHLPPRYPQQHPQPHPQLHQHQHLHPQPPLQYPAVGSSQHFDLAQSLDLCDGGIPGYQDGLGDLGFLGGGIAQMGKKSELSFLLMEEALSPLGGDPLLSAMSPEASVDSSRRSSFSIEDSDIQ
Protein: Progonadoliberin-1 (Progonadoliberin I) [Cleaved into: Gonadoliberin-1 (Gonadoliberin I) (Gonadorelin) (Gonadotropin-releasing hormone I) (GnRH-I) (Luliberin I) (Luteinizing hormone-releasing hormone I) (LH-RH I); GnRH-associated peptide 1 (GnRH-associated peptide I)] (P01148)
Organism: Homo sapiens (Human)
Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular location: Secreted.
Interaction partners:
- Gonadotropin-releasing hormone receptor
- Progonadoliberin-2
- KiSS-1 receptor
- Metastasis-suppressor KiSS-1
- RAC-alpha serine/threonine-protein kinase
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- Muellerian-inhibiting factor
- RAC-gamma serine/threonine-protein kinase
- RAC-beta serine/threonine-protein kinase
Sequence:
MKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI
Protein: Alpha-2-macroglobulin (ECAM) (P76578)
Organism: Escherichia coli (strain K12)
Function: Protects the bacterial cell from host peptidases. Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase. Trapped peptidases are still active except against very large substrates. May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:18697741, ECO:0000269|PubMed:21210718}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}; Periplasmic side {ECO:0000269|PubMed:18697741}.
Interaction partners:
- Penicillin-binding protein 1C
- Transcriptional repressor NrdR
- Uncharacterized protein YfaT
Sequence:
MKKLRVAACMLMLALAGCDNNDNAPTAVKKDAPSEVTKAASSENASSAKLSVPERQKLAQQSAGKVLTLLDLSEVQLDGAATLVLTFSIPLDPDQDFSRVIHVVDKKSGKVDGAWELSDNLKELRLRHLEPKRDLIVTIGKEVKALNNATFSKDYEKTITTRDIQPSVGFASRGSLLPGKVVEGLPVMALNVNNVDVNFFRVKPESLPAFISQWEYRNSLANWQSDKLLQMADLVYTGRFDLNPARNTREKLLLPLGDIKPLQQAGVYLAVMNQAGRYDYSNPATLFTLSDIGVSAHRYHNRLDIFTQSLENGAAQQGIEVSLLNEKGQTLTQATSDAQGHVQLENDKNAALLLARKDGQTTLLDLKLPALDLAEFNIAGAPGYSKQFFMFGPRDLYRPGETVILNGLLRDADGKALPNQPIKLDVIKPDGQVLRSVVSQPENGLYHFTWPLDSNAATGMWHIRANTGDNQYRMWDFHVEDFMPERMALNLTGEKTPLTPKDEVKFSVVGYYLYGAPANGNTLQGQLFLRPLREAVSALPGFEFGDIAAENLSRTLDEVQLTLDDKGRGEVSTESQWKETHSPLQVIFQGSLLESGGRPVTRRAEQAIWPADALPGIRPQFASKSVYDYRTDSTVKQPIVDEGSNAAFDIVYSDAQGVKKAVSGLQVRLIRERRDYYWNWSEDEGWQSQFDQKDLIENEQTLDLKADETGKVSFPVEWGAYRLEVKAPNEAVSSVRFWAGYSWQDNSDGSGAVRPDRVTLKLDKASYRPGDTIKLHIAAPTAGKGYAMVESSEGPLWWQEIDVRAQGLDLTIPVDKTWNRHDLYLSTLVVRPGDKSRSATPKRAVGVLHLPLGDENRRLDLALETPAKMRPNQPLTVKIKASTKNGEKPKQVNVLVSAVDSGVLNITDYVTPDPWQAFFGQKRYGADIYDIYGQVIEGQGRLAALRFGGDGDELKRGGKPPVNHVNIVVQQALPVTLNEQGEGSVTLPIGDFNGELRVMAQAWTADDFGSNESKVIVAAPVIAELNMPRFMASGDTSRLTLDITNLTDKPQKLNVALTASGLLELVSDSPAAVELAPGVRTTLFIPVRALPGYGDGEIQATISGLALPGETVADQHKQWKIGVRPAFPAQTVNYGTALQPGETWAIPADGLQNFSPVTLEGQLLLSGKPPLNIARYIKELKAYPYGCLEQTASGLFPSLYTNAAQLQALGIKGDSDEKRRASVDIGISRLLQMQRDNGGFALWDKNGDEEYWLTAYVMDFLVRAGEQGYSVPTDAINRGNERLLRYLQDPGMMSIPYADNLKASKFAVQSYAALVLARQQKAPLGALREIWEHRADAASGLPLLQLGVALKTMGDATRGEEAIALALKTPRNSDERIWLGDYGSSLRDNALMLSLLEENKLLPDEQYTLLNTLSQQAFGERWLSTQESNALFLAARTIQDLPGKWQAQTSFSAEQLTGEKAQNSNLNSDQLVTLQVSNSGDQPLWLRMDASGYPQSAPLPANNVLQIERHILGTDGKSKSLDSLRSGDLVLVWLQVKASNSVPDALVVDLLPAGLELENQNLANGSASLEQSGGEVQNLLNQMQQASIKHIEFRDDRFVAAVAVDEYQPVTLVYLARAVTPGTYQVPQPMVESMYVPQWRATGAAEDLLIVRP
Protein: Large ribosomal subunit protein eL6y (60S ribosomal protein L6-2) (Q9C9C6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL6z/uL6y
- Large ribosomal subunit protein uL24z
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein uL24y
- Large ribosomal subunit protein eL22z
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein uL22z
Sequence:
MPAKQRTAKVNRNPDLIRGVGKYSRSQMYHKRGLWAIKAKNGGVFPRHDAKSKVDAPVEKPPKFYPAEDVKKPLPNRRTAKPAKLRASITPGTVLIILAGRFKGKRVVFLKQLASGLLLVTGPFKINGVPLRRVNQAYVIGTSTKVDISGVTLDKFDDKYFGKVAEKKKKKTEGEFFEAEKEEKKEIPQGKKDDQKAVDAALIKAIEAVPELKTYLGARFSLKQGMKPHELVF
Protein: Fas-binding factor 1 (FBF-1) (A2A870)
Organism: Mus musculus (Mouse)
Function: Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:10978533}. Cell junction {ECO:0000250}. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to the apical junction complex (AJC) in epithelial cells (By similarity). {ECO:0000250}.
Interaction partners:
- Sodium channel and clathrin linker 1
- Centrosomal protein of 83 kDa
- Centrosomal protein of 89 kDa
- Centrosomal protein of 164 kDa
- TRAF3-interacting protein 1
- Ninein
- Outer dense fiber protein 2
- 5'-3' exoribonuclease 2
- Decapping and exoribonuclease protein
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MTGQCCEELQRAPKPRMALRTKKGLKGSIEDVLGDLLGDDTTPPEKPAEPASHAKDTASSPQWQASKAKFLPKDSVEGLAGADAEASSVSDADPQVFLQNMKDLDSMDDDLFGRMKSHQPSGKGAAKGPGKEGPSNHKPAGTLTANEKGYTMPTKKPPPSSSKTGLQYKKFSFEDFEDPLAGLLSDEEEETATKLPAVERKPAPKSPGAAAGQGPSVPLTPGDTPIRKKELLFDEGDDIMTTLGFEDSPKAERKKTGDQEGPLPARSKLDELLGRGTAAKLLTRPGTGERREFQLDKKYQKMGGEESVPARDKEDSWDDETLTFGAYKPTVASSEGRQSRRQSVSRFLGEGGPDPKGESLGFKQSSPPASSPIHPRKGGADWLGLKDNDLDLLSPSPVQKAQQEDSPMTPSLLPPTNQPSAPEPQSAPTGLPSAAKPPAKGARPSLKASQASSPKASEEKEDDWLSHVISQKKSQNLAREERAGPPKDLASLGSLGQTPSGSLPVAQVLEQAPAGEASKPTTQGMAAVRPGVTGSSMSWSQATTVLPVDDPKKGAASASGDFSSREPAVYIPHSQEPTGLSVPIQTLLPESMMQSLLPGSGYQKQLLAAQGQLQSSTAQLQVELLQSQTKLSELEAQVRKLELERAQHRMLLESLQQRHQADLELIEDAHRSRIKVLETSYQQREEQLRREKEVLSAQHASYCREAEQARAELVAQHQRQMAMAEQERDQEVARLRELQQASILEMRKDHEHQLQRLKMLKDQEIDAVTSATSHTRSLNGIIEQMEKFSSSLNTLSSRVEASHLTTSQQRELGIRQQDEQLRALQERLGRQQRDMEEERNRLQEVIGKMEVRLSEQSRLLEQERWRVAAEKTKAESAQRTLEEQRKIMVQQIAMEREELERAKSALLEEQKSVMNKCGEERRRLAAEWAEYFTQQKLSKERAEREAERAMHADSQREGTIISLTKEQAELTVRACELRAKEEKLLAEREALERERQELRLEKDRLHKASLRLQARAQEVEHMSKVASKKYEEGEQALQEAQQMQNEQQGRLQVVQRQQEWLRQQEQRVHQEHLSLAQQRLQLDRVRQEVPASLPGLPPRVQGPAASSRDAVQAPASSSPQCSQPAAAQVPTHLLAKLLLLKHTAEEDHDFLENEQFFLETLKKAPYNMAYHSA
Protein: Storkhead-box protein 2 (Q9P2F5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKKTRSTTLRRAWPSSDFSDRASDRMRSRSEKDYRLHKRFPAAFAPQASRGYMTSGDVSPISMSPISQSQFIPLGEILCLAISAMNSARKPVTQEALMEHLTTCFPGVPTPSQEILRHTLNTLVRERKIYPTPDGYFIVTPQTYFITPSLIRTNSKWYHLDERIPDRSQCTSPQPGTITPSASGCVRERTLPRNHCDSCHCCREDVHSTHAPTLQRKSAKDCKDPYCPPSLCQVPPTEKSKSTVNFSYKTETLSKPKDSEKQSKKFGLKLFRLSFKKDKTKQLANFSAQFPPEEWPLRDEDTPATIPREVEMEIIRRINPDLTVENVMRHTALMKKLEEEKAQRSKAGSSAHHSGRSKKSRTHRKSHGKSRSHSKTRVSKGDPSDGSHLDIPAEREYDFCDPLTRVPREGCFIIEHKGDNFIMHSNTNVLESHFPMTPEWDVSGELAKRRTEMPFPEPSRGSSHSKVHRSHSHTQDRRSRNERSNKAKERSRSMDNSKGPLGASSLGTPEDLAEGCSQDDQTPSQSYIDDSTLRPAQTVSLQRAHISSTSYKEVCIPEIVSGSKEPSSACSLLEPGKPPESLPSYGELNSCPTKTATDDYFQCNTSSETVLTAPSPLGKNKEDHDTLTLAEGVKKLSPSDRQVPHSSREPVGHKEESPKGPGGGPAASGGVAEGIANGRLVQHHGAEPSSLDKRKEIFSKDTLFKPLHSTLSVNSYHKSSLSLLKSHPKTPADTLPGRCEKLEPSLGTSAAQAMPASQRQQESGGNQEASFDYYNVSDDDDSEEGANKNTEEEKNREDVGTMQWLLEREKERDLQRKFEKNLTLLAPKETDSSSNQRATHSARLDSMDSSSITVDSGFNSPRTRESLASNTSSIVESNRRQNPALSPAHGGAGPAFNFRASAEPPTNEAEKLQKPSNCLQASVTSV
Protein: Ornithine decarboxylase antizyme 3 (A0A0G2JH29)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTVPWRPGKRRITYKEEEDLTLQPRSCLQCSESLVGLQEGKSTEQGNHDQLKELYSAGNLTVLATDPLLHQDPVQLDFHFRLTSQTSAHWHGLLCDRRLFLDIPYQALDQGNRESLTATLEYVEEKTNVDSVFVNFQNDRNDRGALLRAFSYMGFEVVRPDHPALPPLDNVIFMVYPLERDVGHLPSEPP
Protein: Proteasome subunit beta (A0AQH0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU004203}. Nucleus {ECO:0000256|RuleBase:RU004203}.
Interaction partners:
- Proteasome subunit beta
- Proteasome subunit beta
- Proteasome subunit beta type-4
- Proteasome subunit beta
- Proteasome subunit beta type-3
- Proteasome subunit alpha type-7-1
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-3
Sequence:
MQPDFDFTDTPVSTGTTIMAVEFDGGVVIGADSRTSSGAYVANRVTDKLTRITDKVYCCRSGSAADTQAIADIVAYSLNYHENQTNKDALVFEAASEFRNYCYSYRESLLAGIIVAGWDEQRGGQVYSIPLGGMLTRESCTIGGSGSSFIYGFVREHYRPNMALEDCVTFVKKAVQHAIYHDGSSGGVVRIGIITKDGIERRIFYNTESGASAVSSTPSFISSE
Protein: Janus kinase and microtubule-interacting protein 1 (GABA-B receptor-binding protein) (Multiple alpha-helices and RNA-linker protein 1) (Marlin-1) (Q8BVL9)
Organism: Mus musculus (Mouse)
Function: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MSKKGRSKGDKPEAETDSVQMANEELRAKLTNIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREALIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLADAREEARRTFDGERQRLQQEILELKAARKQAEEALSNCMQADKAKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKERVILALEKELGVQTGQTQRLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMAELMGGQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEELLHSIQRMEEKLKSLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDETTTREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDAAWVEEKQVLMRTNQDLLEKIYRLEMEENQLKSEMQDAKDQNELLEFRVLELEVRDSICCKLSNGADILFEPKLKFM
Protein: Regulator of sex limited protein 1 (Regulator of sex-limitation 1) (Q7M6Y1)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Zinc finger protein 455
Sequence:
MRLSIPVVSDKKEMLSFWDVAIDFSPEEWECLEPAQWDLYRDVMLENFSHLVFLGLAVSKPFLVTFLEQIQGPWDMKRQGTAPVYPGIIPNDPNNCSKLTNCKSLLITQRRNHIGEKPYKCGECGKALSSHKTLSIHQRLHTGDKPYKCEECHKAFSTRSSLFIHMKNHTDEKIYKCEDCGRTFYYLSMLKQHQRIHSGEKPYKCEECGKSFSFPSFLKQHQRLHCRKNAFKHEQCVNRFPPPLPLQEHEQIRTEEKPYKCGECYKTFRYHSALRIHKAVHTGERPYKCEECGKCFSSSSCLKKHQILHSEDNPYKCEECYKAFRNHSALRIHKTVHTGERPYKCQECGKCYSSPSCLKRHQILHSKYNPYKCEECGKCLSSSSCLKTHQTLHSEDKPYKCEDCSRCFCSSSSLRRHQKFHSEGNPYKCEKCDKRFSCSAGLQDHQTIHTGEKPYRCENCHKAFCYRSSLRKHKTVHTREKSTHM
Protein: ILK associated serine/threonine phosphatase (E9PC05)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSGSLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVSSSVIFGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWK
Protein: Tousled-like kinase, isoform K (EC 2.7.11.1) (M9PIZ6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRSKRNTSDLGLLQRTCIVGGKSMSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS
Protein: Flagellar protein FliL (P0ABX8)
Organism: Escherichia coli (strain K12)
Function: Controls the rotational direction of flagella during chemotaxis.
Subcellular location: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Flagellar basal body rod protein FlgB
- Flagellar motor switch protein FliN
- Flagellar motor switch protein FliG
- Flagellar motor switch protein FliM
- Flagellar biosynthetic protein FliQ
- Flagellar M-ring protein
- Flagellar protein FliO
- Flagellar FliJ protein
- Flagellar hook-basal body complex protein FliE
- Flagellar hook-length control protein
Sequence:
MTDYAISKKSKRSLWIPILVFITLAACASAGYSYWHSHQVAADDKAQQRVVPSPVFYALDTFTVNLGDADRVLYIGITLRLKDEATRSRLSEYLPEVRSRLLLLFSRQDAAVLATEEGKKNLIAEIKTTLSTPLVAGQPKQDVTDVLYTAFILR
Protein: Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4) (Q9R155)
Organism: Mus musculus (Mouse)
Function: Sodium-independent transporter of chloride and iodide (By similarity). Mediates electroneutral iodide-chloride, iodide-bicarbonate and chloride-bicarbonate exchange with 1:1 stoichiometry. Mediates elctroneutral chloride-formate exchange (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:11274445, ECO:0000269|PubMed:11459928, ECO:0000269|PubMed:18565999, ECO:0000269|PubMed:35601831}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:11459928}; Multi-pass membrane protein {ECO:0000269|PubMed:11459928}. Note=Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney. {ECO:0000269|PubMed:11274445}.
Interaction partners:
- Gap junction beta-2 protein
- ATP-sensitive inward rectifier potassium channel 10
- Forkhead box protein I1
- Sodium/iodide cotransporter
- Iodotyrosine deiodinase 1
- Electroneutral sodium bicarbonate exchanger 1
- Cystic fibrosis transmembrane conductance regulator
- Otoferlin
- Transmembrane channel-like protein 1
- Epithelial sodium channel subunit alpha
Sequence:
MAARGGRSEPPQLAEYSCSYTVSRPVYSELAFQQQRERRLPERRTLRDSLARSCSCSRKRAFGVVKTLLPILDWLPKYRVKEWLLSDIISGVSTGLVGTLQGMAYALLAAVPVQFGLYSAFFPILTYFVFGTSRHISVGPFPVVSLMVGSVVLSMAPDDHFLVPSGNGSALNSTTLDTGTRDAARVLLASTLTLLVGIIQLVFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGILSIIYTLIEIFQNIGDTNIADFIAGLLTIIVCMAVKELNDRFKHRIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPSGFLPPVLPSVGLFSDMLAASFSIAVVAYAIAVSVGKVYATKHDYVIDGNQEFIAFGISNVFSGFFSCFVATTALSRTAVQESTGGKTQVAGLISAVIVMVAIVALGRLLEPLQKSVLAAVVIANLKGMFMQVCDVPRLWKQNKTDAVIWVFTCIMSIILGLDLGLLAGLLFALLTVVLRVQFPSWNGLGSVPSTDIYKSITHYKNLEEPEGVKILRFSSPIFYGNVDGFKKCINSTVGFDAIRVYNKRLKALRRIQKLIKKGQLRATKNGIISDIGSSNNAFEPDEDVEEPEELNIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAVSFLDVVGVRSLRMIVKEFQRIDVNVYFALLQDDVLEKMEQCGFFDDNIRKDRFFLTVHDAILHLQNQVKSREGQDSLLETVARIRDCKDPLDLMEAEMNAEELDVQDEAMRRLAS
Protein: Ras association domain-containing protein 7 (HRAS1-related cluster protein 1) (Q02833)
Organism: Homo sapiens (Human)
Function: Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20629633}. Note=Colocalizes with gamma-tubulin.
Interaction partners:
- Apoptosis-stimulating of p53 protein 1
- Apoptosis-stimulating of p53 protein 2
- Ras association domain-containing protein 6
- Disrupted in schizophrenia 1 protein
- Ras association domain-containing protein 10
- Ras association domain-containing protein 5
- Ras association domain-containing protein 2
- Ras association domain-containing protein 1
- Ras association domain-containing protein 3
- Ras association domain-containing protein 9
Sequence:
MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPAPEWCPLAAQPQAL
Protein: mRNA stability protein IGO2 (Initiation of G zero protein 2) (Q9P305)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for TORC1 to properly control gene expression and chronological life span. Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Serine/threonine-protein kinase RIM15
- Protein phosphatase PP2A regulatory subunit B
- mRNA stability protein IGO1
- ATP-dependent RNA helicase DHH1
- Protein ZDS2
Sequence:
MSEDLSPTSSRVDLSNPHGFTKEGVDLSKLSPQELKLYKMYGKLPSKKDLLRHKMQDRQYFDSGDYALKKAGVIKSDDVIVNNSSNNLPVTNPSGLRESIIRRRMSSSSGGDSISRQGSISSGPPPRSPNK