wanglab/gogpt-training-data huggingface dataset:
Protein: Growth/differentiation factor 8 (GDF-8) (Myostatin) (O35312)
Organism: Rattus norvegicus (Rat)
Function: Acts specifically as a negative regulator of skeletal muscle growth.
Subcellular location: Secreted {ECO:0000250|UniProtKB:O08689}.
Interaction partners:
- Activin receptor type-2B
- Activin receptor type-1B
- TGF-beta receptor type-1
- Activin receptor type-2A
- Follistatin
- Follistatin-related protein 3
- Receptor protein serine/threonine kinase
- Mothers against decapentaplegic homolog 2
- F-box only protein 32
- Myoblast determination protein 1
Sequence:
MIQKPQMYVYIYLFVLIAAGPVDLNEDSEREANVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVKAQLWIYLRAVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Protein: Cytochrome P450 716A1 (EC 1.14.-.-) (Q9LVY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses triterpene oxidizing activity. Catalyzes the C28 hydroxylation of alpha-amyrin, beta-amyrin, and lupeol, producing uvaol, erythrodiol, and betulin, respectively. Catalyzes the C28 carboxylation of alpha- and beta-amyrin.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MYMAIMIILFLSSILLSLLLLLRKHLSHFSYPNLPPGNTGLPLIGESFSFLSAGRQGHPEKFITDRVRRFSSSSSCVFKTHLFGSPTAVVTGASGNKFLFTNENKLVVSWWPDSVNKIFPSSMQTSSKEEARKLRMLLSQFMKPEALRRYVGVMDEIAQRHFETEWANQDQVIVFPLTKKFTFSIACRSFLSMEDPARVRQLEEQFNTVAVGIFSIPIDLPGTRFNRAIKASRLLRKEVSAIVRQRKEELKAGKALEEHDILSHMLMNIGETKDEDLADKIIGLLIGGHDTASIVCTFVVNYLAEFPHVYQRVLQEQKEILKEKKEKEGLRWEDIEKMRYSWNVACEVMRIVPPLSGTFREAIDHFSFKGFYIPKGWKLYWSATATHMNPDYFPEPERFEPNRFEGSGPKPYTYVPFGGGPRMCPGKEYARLEILIFMHNLVNRFKWEKVFPNENKIVVDPLPIPDKGLPIRIFPQS
Protein: Cysteine-tryptophan domain-containing zinc finger protein 3 (OsCW-ZF3) (Q0DRX6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Binds to histones H3K4me1, H3K4me2 and H3K4me3 in GST pull-down assay. May facilitate the recruitment of effectors to mediate gene expression (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:28818372}.
Interaction partners:
Sequence:
MPSNGGIIPGPANAASLPAPVLIEDNWVCCDMCHKWRLLPYGTNTSMLPKKWICSMLDWLPGMNKCDISEDETTNALNALYVTQIPAAGVSSGGPHTAHASVAASSTYNISGQLGQSRKRKNALKDENCYEHDQQAPAKMTLTSNQQAPAKNREVVDSEHYTNDRDPVSTHDLVPQSKSASERHKSKHKSRSSHSDGGDLTEKSKKHSKSKNRRGIDRDEHKTSKKTKKEDRHYFNKDWKNEYDLAGNKVRDETKALSAKAKMSKDSCEQDEFSLRKEKASRFDILEKTKRINDDDVAFHEKMKEHRAGIETLDLSGKKKTVKEWEDNRLSSMDHTSKGGDNENLNERLSKIKKSEARPEEVQDANALFSSAGRRQDNELVADNKFVTCKEGPSELWDNQPPRQVLNLAEPTRRDVACLQSSTVATSSSSKVSSSRRNKNSREAKGSPVESVSSSPLKNSNTDKISKARKTGKDGELNADSSILHTPMKYPTHEVGLLHTGQQAVGEAILRGSTNNSGMGRVDNQLYPGDKKILDMHGPTLQPDQQDCFNPRATADSTGHKSKNSAPSRQGRNGSSNLISEGNKQIEMSSRKEKLRPSIDNQDMQKSIGQDNHSHMKEGKSEVHTTRVKPGASKNHTQLRSNVENGDSASPIRRDGNMIAFALKEARDLKHKANHLKEKGLELESMGLYFEAALKFLHVASLWETPNLDNSRSGDVAQSMKMYSETAKLCSFCAHAYERCNKMASAALAYKCVEVAYLKAAYYKHPSASKDRQELQSVVQIAPGESPSSSASDIDNLNSHGLSKALSTKGGNSPQVAGNHLPLAVRNQAHLLRLLAYTNDVNCAFDATRKSQVAIASAASSQERGKTVDDGLASVRTVLDFNFNNVNELLRLVRLSMELINT
Protein: SD14463p (Q8IG99)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKRATGAGGGVGGRPGPYDIRDRGANRGGNDFGGGRNDWGNNGNFGVGANNMLGFNNLPSLMNSGNFGNNQGGNNGNFGNNSGPSNFGNFGGGNNGGNSGNFGNDSGNSGNFGNFGNNGGGNFGGNNNGGGGFNSGNNFNSPGGVNNFGNNGGSNFGGNGGGGFNNGGNFVSSSGVGNFGPIGGGRNNNNGNFGNSGFGNFGGNNNVGSNFGGGNNGGGGGFNNGSNFGGGNSMGGGGNFGPIGGGRGNDIEYYTIHMRGLPYTSFENDVFKFFEPIRPANVRINYNKKGLHSGTADAYFDTYEDSQVAMKRHREQMGSRYIELFYDGKTRGLNGGEHGGGNGGGGMGNNGGGNFSRRI
Protein: 2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase PapA1 (EC 2.3.1.283) (Polyketide synthase-associated protein A1) (SL659 acyltransferase PapA1) (P9WIK9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Required for the biosynthesis of sulfolipid-1 (SL-1), a major mycobacterial cell wall lipid. Catalyzes the acylation of trehalose-2-sulfate-2'-palmitate (SL659) by adding the (hydroxy)phthioceranoyl group at the 3'-position to yield the diacylated intermediate 2-palmitoyl-3-(C43)-phthioceranyl-alpha, alpha'-D-trehalose-2'-sulfate (SL1278).
Interaction partners:
- Phthioceranic/hydroxyphthioceranic acid synthase
- Sulfolipid-1 exporter MmpL8
- Mycolipanoate synthase
- Probable multifunctional mycocerosic acid synthase membrane-associated Mas
- Mycocerosic acid synthase-like polyketide synthase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Long-chain-fatty-acid--AMP ligase FadD23
- Mycoketide-CoA synthase
- Polyketide synthase Pks13
- Acyltrehalose exporter MmpL10
Sequence:
MRIGPVELSAVKDWDPAPGVLVSWHPTPASCAKALAAPVSAVPPSYVQARQIRSFSEQAARGLDHSRLLIASVEVFGHCDLRAMTYVINAHLRRHDTYRSWFELRDTDHIVRHSIADPADIEFVPTTHGEMTSADLRQHIVATPDSLHWDCFSFGVIQRADSFTFYASIDHLHADGQFVGVGLMEFQSMYTALIMGEPPIGLSEAGSYVDFCVRQHEYTSALTVDSPEVRAWIDFAEINNGTFPEFPLPLGDPSVRCGGDLLSMMLMDEQQTQRFESACMAANARFIGGMLACIAIAIHELTGADTYFGITPKDIRTPADLMTQGWFTGQIPVTVPVAGLSFNEIARIAQTSFDTGADLAKVPFERVVELSPSLRRPQPLFSLVNFFDAQVGPLSAVTKLFEGLNVGTYSDGRVTYPLSTMVGRFDETAASVLFPDNPVARESVTAYLRAIRSVCMRIANGGTAERVGNVVALSPGRRNNIERMTWRSCRAGDFIDICNLKVANVTVDREA
Protein: Poly(A) polymerase (EC 2.7.7.19) (Q9N6D7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR018425}.
Interaction partners:
Sequence:
MWNSEPTHRQHHQHNGNSTSGGPPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEISVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVTECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDEILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAAATLVHKFFLVFSRWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVSESTKKVILTEFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVESKVRLLIGNLERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSMWFIGLEFERSENLNVDLTESIQNFTEHVMMHGVNIKMLKEGMTIDARHVKRKQLSLYLDSDFLKRERKSMESHNNFNNTLLANRKRLSTELAQSQDPLPPGQQPSSGNRGRDSGAKIQRLSDSLTEENSNASSDMGAGTPTTPTTAQLSAPSFKSSGKNGSEIDVVEQEPTQPHNNGNASSNTTTTEVACS
Protein: RE04135p (Q8MZ32)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDVEEFRKYGKEVIDYICQYSTNIEERDVAPTLDPGYLKKLLPADAPQSPEPFKDVLEDFEQKIMPGVVHWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGLPKAFVSDAPGSTGGGALQGSASECVLVSLITARARAISELKGQTSVHDSVFLPSLIAYASREAHSSVEKATKMALVKLRIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFDDITEIGKVCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASALWVRDVMNLKSALNVNPLYLRHEHLTGVDYRHYGIPLSRRFRALKLWFVFRTYGIRGLQEYIRNHMALAKKFEMLVRKDERFEVRNDVHLGLVCFRMRTGDEPNHMLLAQINHSGKMHMTPAKFNGRYVIRFCVTYEHATEKDILEAWTQIKCFAEEILRDHQLESSSVPTTPEGSERTSSEPLAPVAGKPPIKKRLTRTKSLRFSFTRSISREQYQSQSEHLMDGCTPILVVDPKTLQENFQKAADDNDRNNSNGNVKLKDISDVDTDEASN
Protein: Protein ELF4-LIKE 2 (Q94BS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Acetyl-CoA acetyltransferase 2
- Acetyl-CoA acetyltransferase 1
- 3-ketoacyl-CoA thiolase 1, peroxisomal
- 3-ketoacyl-CoA thiolase 5, peroxisomal
- 3-ketoacyl-CoA thiolase 2, peroxisomal
- COP1-interacting protein-like protein
- Protein ANTHESIS POMOTING FACTOR 1
- Probable carboxylesterase 17
- At5g40020
- AT4g33140/F4I10_70 superfamily protein)
Sequence:
MESRMEGDVYSGFGERYQMDGKLLQNFQKSFVQVQDILDQNRLLINEINQNHESKQADHLGRNVGLIRELNNNIRTVASLYGDLSHSFARSVDASSEGESTGTLKSDGKANNQKRFRSG
Protein: Cilium assembly protein DZIP1 (DAZ-interacting protein 1/2) (DAZ-interacting zinc finger protein 1) (Q86YF9)
Organism: Homo sapiens (Human)
Function: Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium (By similarity). Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium. It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN (By similarity). Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm (By similarity). It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum. Also indirectly involved in heart development through its function in ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19852954}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:27979967}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19852954}. Nucleus {ECO:0000269|PubMed:15081113}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BMD2}. Cytoplasm {ECO:0000269|PubMed:15081113}. Note=Localizes to the centriole in cells lacking cilia and to the cilium basal body in ciliated cells (PubMed:19852954). At the exit of mitosis, when the primary cilium is reassembled in daughter cells, localizes at the mother centriole that acts as the basal body of the assembling primary cilium and also accumulates at the ciliary base that constitutes a diffusion barrier for ciliary proteins (By similarity). {ECO:0000250|UniProtKB:Q8BMD2, ECO:0000269|PubMed:19852954}.
Interaction partners:
- Deleted in azoospermia protein 1
- Deleted in azoospermia-like
- Hyaluronan mediated motility receptor
- Protein chibby homolog 1
Sequence:
MQAEAADWFSSMPFQKHVYYPLASGPEGPDVAVAAAAAGAASMACAPPSAASGPLPFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKGNPLAWQAFESQPAAPAVPMNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEHQVSCKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIRAYASPGPLPVPPPQNKGSFGKNTVKSDADGTEGSEIEDTDDSPKPAGVAVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFIKKEELQELKCADVEDEDWDISSLEEEISLGKKSGKEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKGEGLQENESSTLKSSLVTVTDWSDTSDV
Protein: Keratin, type I cytoskeletal 27 (Cytokeratin-27) (CK-27) (Keratin complex-1, acidic, gene C29) (Keratin-27) (K27) (Type I inner root sheath-specific keratin-K25irs3) (Q9Z320)
Organism: Mus musculus (Mouse)
Function: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14996088}.
Interaction partners:
- Keratin, type I cuticular Ha5
- Keratin, type II cytoskeletal 71
- Keratin, type I cuticular Ha1
- Keratin, type I cuticular Ha3-I
- Keratin, type I cytoskeletal 25
- Keratin, type I cytoskeletal 26
- Keratin-associated protein 3-1
- Keratin, type I cytoskeletal 28
- Keratin, type I cuticular Ha4
- Proline-rich protein 9
Sequence:
MSVRFSSASRRLGSVRLSSAGAALGAGNACGVPGIGSGFSCAFGGSSLAGGLGMGGASCGAFTANEHGLLSGNEKVTMQNLNDRLASYLENVQALEEANADLEQKIKDWYEKFGPGSCRGLDHDYSRYFPIIDDLRTQIISATAHNANIILQNDNARLTADDFRMKYENELALHQSVDADINGLRRVLDELTLCRTDLEVQLETLSEELAYLKKNHEEEMQALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSASLQQQISDDAGATTSARNELTEMKRTLQTLEIELQSLLAMKHSLECSLTETEGNYCTQLAQIQAQISALEEQLHQVRTETEGQKLEYEQLLNVKAHLEKEIETYCRLIDGDEGSCVKAKGQGRPGNQTKDSPKTAIVKTVVEELDPRGKVLSSRVHTLEEKSTKVNKTEQRIPS
Protein: Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) (Q92854)
Organism: Homo sapiens (Human)
Function: Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Plexin-B2
- Plexin-B1
- B-cell differentiation antigen CD72
- Plexin-B3
- Receptor-type tyrosine-protein phosphatase C
- Rho-related GTP-binding protein Rho6
- Ras-related protein R-Ras
- Plexin-A2
- Hepatocyte growth factor receptor
- Plexin-C1
Sequence:
MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMSLFLFFFVLFLCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDFCDREQSLKETLVEPGSFSQQNGEHPKPALDTGYETEQDTITSKVPTDREDSQRIDDLSARDKPFDVKCELKFADSDADGD
Protein: Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (Acyltransferase ZDHHC3) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 3) (Q2TGK3)
Organism: Rattus norvegicus (Rat)
Function: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (By similarity). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (By similarity). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (By similarity). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes (By similarity). Also constitutively palmitoylates DLG4. May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:19596852}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the Golgi cis cisterna. {ECO:0000250|UniProtKB:Q8R173}.
Interaction partners:
Sequence:
MMLIPTHHFRDIERKPEYLQPEKCAPPPFPGPVGTMWFIRDGCGIACAIVTWFLVLYAEFVVLFVMLIPSRDYAYSIINGIVFNLLAFLALASHCRAMLTDPGAVPKGNATKEFIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTKCSSFSPPTTVILLILLCFEALLFLIFTSVMFGTQVHSICTDETGIEQLKKEERRWAKKTKWMNMKAVFGHPFSLGWASPFATPDQGKADPYQYVV
Protein: Transcription factor bHLH62 (Basic helix-loop-helix protein 62) (AtbHLH62) (bHLH 62) (Transcription factor EN 85) (bHLH transcription factor bHLH062) (Q9SRT2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- At5g07400
- AT1G56000 protein
- Spectrin beta chain, brain
Sequence:
MENELFMNAGVSHPPVMTSPSSSSAMLKWVSMETQPVDPSLSRNLFWEKSTEQSIFDSALSSLVSSPTPSNSNFSVGGVGGENVIMRELIGKLGNIGDIYGITASNGNSCYATPMSSPPPGSMMETKTTTPMAELSGDPGFAERAARFSCFGSRSFNSRTNSPFPINNEPPITTNEKMPRVSSSPVFKPLASHVPAGESSGELSRKRKTKSKQNSPSAVSSSKEIEEKEDSDPKRCKKSEENGDKTKSIDPYKDYIHVRARRGQATDSHSLAERVRREKISERMKLLQDLVPGCNKVTGKALMLDEIINYVQSLQRQVEFLSMKLSSVNTRLDFNMDALLSKDIFPSSNNLMHHQQVLQLDSSAETLLGDHHNKNLQLNPDISSNNVINPLETSETRSFISHLPTLAHFTDSISQYSTFSEDDLHSIIHMGFAQNRLQELNQGSSNQVPSHMKAEL
Protein: Neuronal vesicle trafficking-associated protein 2 (Neuron-specific protein family member 2) (Q3KR51)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000269|PubMed:28874679}; Single-pass type II membrane protein {ECO:0000269|PubMed:28874679}. Golgi apparatus, trans-Golgi network membrane. Cell projection, dendrite {ECO:0000269|PubMed:28874679}. Endosome membrane {ECO:0000269|PubMed:28874679}. Early endosome membrane {ECO:0000269|PubMed:28874679}. Late endosome membrane {ECO:0000269|PubMed:28874679}. Lysosome lumen {ECO:0000269|PubMed:28874679}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P47759}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P47759}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:P47759}. Note=Endocytosed from the cell surface, thus entered into early endosomes, trafficks to late endosomes and degradates in lysosomes (PubMed:28874679). Mainly Golgi stack, but also found in small vacuolar organelles and multivesicular bodies. Found in both stationary and motile endosomes (By similarity). {ECO:0000250|UniProtKB:P47759, ECO:0000269|PubMed:28874679}.
Interaction partners:
Sequence:
MVKLNGNPGEKGAKPPSVEDGFQTVPLITPLEVNHLQLSAPEKVIVKTRTEYQPEQRNKGKFRVPKIAEFTVTILVSLALAFLACIVFLVVYKAFTYDHSCPEGFVYKHKRCIPASLDAYYSSQDPSSRSRFYTVISHYSVAKQSTARAIGPWLSAAAVIHEPKPPKTQGH
Protein: Trypanothione synthetase (EC 6.3.1.9) (Q9GT49)
Organism: Trypanosoma cruzi (strain CL Brener)
Function: Bifunctional enzyme which catalyzes the formation of trypanothione (N(1),N(8)-bis(glutathionyl)spermidine) from glutathione and spermidine. Converts spermidine or glutathionylspermidine into trypanothione. Can also convert aminopropylcadaverine into glutothionylaminopropylcadaverine and homotrypanothione. Also has low amidase activity, hydrolyzing trypanothione, homotrypanothione or glutathionylspermidine to form glutathione and the corresponding polyamine.
Interaction partners:
- Trypanothione reductase
- thioredoxin-dependent peroxiredoxin
- thioredoxin-dependent peroxiredoxin
- thioredoxin-dependent peroxiredoxin
- thioredoxin-dependent peroxiredoxin
- thioredoxin-dependent peroxiredoxin
- Transcription factor CBF/NF-Y/archaeal histone domain-containing protein
- Spermidine synthase, putative
- Spermidine synthase, putative
- Spermidine synthase, putative
Sequence:
MPTLQSLAVPFGCVQGYAPGGIPAYSNKHESYFSGERSIDGNLFCGFKYQCVEFARRWLFERKSLVLPDVDWAVHIFNLKEVSDARTGKPVRCVAIRNGTAAKPVVDSLLIYPSDDYSPVGHVAAITEVGDKWVRIADQNHRFHKWDANYAAELPLIHEKGVWTILDPLEDEVLKPLGWVTFPDTPDRNPNEPLVLHESLHFKRGELPTLRRLTFTPTSREKDWLDLTNEAEAYFADVCGIDVKNPKLEKASYYQMNRELYLDCAKYGNQLHQMFLEATKFVLGSDELLRLFCIPEEYWPRLRHSWETQPHAITGRFDFAFDEDTQQFKCFEYNADSASTLLECGVIQQKWARSVGLDDGTTYSSGSLVSSRLQLAWEMAEVTGRVHFLIDNDDEEHYTALYVMQHASAAGLETKLCVLFDEFHFDENGVVVDSDGVAVTTVWKTWMWETAIADHQKARVQRGNDWRPTPKDEVRLCDILLGPNWDLRVFEPMWKIIPSNKAILPIIYNKHPDHPALLRASYELTVELQRTGYVRKPIVGRVGRNVTVTEASGDIAAKSDGDFSDRDMVYQELFRLPERDGYYAILGGWVIGDVYCGTGVREDKTIITGLESPFSALRVYQGAQRRPLTHEDLDKAEAAAVGGGLKT
Protein: Melanopsin-A (Mammalian-like melanopsin) (Melanopsin-M) (Opsin-4-A) (Opsin-4M) (Q2KNE5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Photoreceptor implicated in non-image-forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9QXZ9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MMSGAAHSVRKGISCPTQDPNCTRIVESLSAWNDSVMSAYRLVDLPPTTTTTTSVAMVEESVYPFPTVDVPDHAHYTIGAVILTVGITGMLGNFLVIYAFSRSRTLRTPANLFIINLAITDFLMCATQAPIFFTTSMHKRWIFGEKGCELYAFCGALFGICSMITLMVIAVDRYFVITRPLASIGVLSQKRALLILLVAWVYSLGWSLPPFFGWSAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFIPLIVIIYCYFFIFRSIRTTNEAVGKINGDNKRDSMKRFQRLKNEWKMAKIALIVILMYVISWSPYSTVALTAFAGYSDFLTPYMNSVPAVIAKASAIHNPIIYAITHPKYRLAIAKYIPCLRLLLCVPKRDLHSFHSSLMSTRRSTVTSQSSDMSGRFRRTSTGKSRLSSASDSESGWTDTEADLSSMSSRPASRQVSCDISKDTAEMPDFKPCNSSSFKSKLKSHDSGIFEKSSSDVDDVSVAGIIQPDRTLTNAGDITDVPISRGAIGRIPSIVITSESSSLLPSVRPTYRISRSNVSTVGTNPARRDSRGGVQQGAAHLSNAAETPESGHIDNHRPQYL
Protein: Matrix metalloproteinase 1, isoform D (EC 3.4.24.-) (Matrix metalloproteinase 1, isoform F) (Matrix metalloproteinase 1, isoform G) (Q8MLN6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTNCQSSVFIVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFPVFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCKNTPSSTGNIVEGSDNEFEQHSMIPHADDGNGDDFDAGEWDRLSGSFV
Protein: Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10) (Q9W4B3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MPQRSPFAIQELLGLAVAAATEAPTDLTTTAGATVAKERQTPTPPKTTNATMATAATSAATAATPTNAAEGNLTSVSEPQQQPQQQQQEQQHHQPHHHQYREHHQMTMAAASRMAYFNAHAAVAAAFMPHQLAAAVHHHHQHQHQHHPHHHPHHPHGAVGGPPPPPPMQHHHPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGSLAPKDFGMESLNGFGVGPNSKKKKKKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMHRKSIEAQSALKDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTSTSGYAGAASSAATTPTGASTTNSSSSPHIELGSPSPQQQQHLQLQQQQQQQASLYLGAGAVVTGCAPPSYHPLLDAANAAGAGAAASSKDFHMIMNTAVAAAAAAAQQQHQQQQQQQQQATATAPGLHAHNLAAALMEHDPDAFRNNSIACLRAKAQEHQARLLNNGGLFLQVRRFAQGQAQIQDPSDMLKLSEEHNNNSPIPIPPAHSTVNTQVNVKMELTANGGSMKNYEEA
Protein: Relaxin family peptide receptor 2 (A0A8I6AND4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MWLLLHVVLLMEVKDFTLAGSNMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNCGDTSGWTTIFGTVHGNVNKVTLTEECFLSRYPQHCYCRENELECVNADLKAVPKVSSNVTLLSLKKNKIHRLPVKVFSKYAELRKIFLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFKDLHQLAWLITNRSILMCFVRILDDNPITRISQRSFTGLNSLFFLSMVSNRLEALPERLCAQMPQLNWVDLANNGIKFITNSTFLTCDSLTVLDLSSNVIAKLPAHLFSDLHLLQKLNLSSNPLLYVHKNQFGSLKQLQSLDLERIEIPNINTGMFRPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISSSEDLLANSILRVSVWVIAFITCAGNFLVIAVRSLIKAENTTHAMSIKILCCADCLMGVYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFSNLRLGKRQTAVVLASIWVAGFLIAAVPFTSEDYFGNFYGKNGVCFPLHYDQAEDFGSRGYSLGIFLGVNLLAFLVITFSYVTMFCSIQKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSLFKDKLKQLLHKHRRKSIFKVKKKSLSASIVWTDDSSLKLGVLNKIALGDSIMKPVSP