wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor MYB97 (Myb-related protein 97) (AtMYB97) (Q9S773)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator. Binds to 5'-CAACTGTC-3' and/or 5'-TAACAAA-3' motif in target gene promoter to promote their expression (By similarity). Together with MYB101 and MYB120, functions as a male factor that controls pollen tube-synergid interaction in fertilization. Required for pollen tube growth arrest and sperm cell release in the female gametophyte, probably via the regulation of pollen tube-specific gene expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:23791732, ECO:0000269|PubMed:24278028}. Note=Detected in the vegetative nucleus of pollen tubes. {ECO:0000269|PubMed:23791732}.
Interaction partners:
- Gb|AAF16529.1
- AP-5 complex subunit beta-like protein
- GPI-anchored protein LORELEI
- Cation/H
- Agamous-like MADS-box protein AGL30
- COBRA-like protein 10
- Receptor-like protein kinase ANXUR1
- Subtilisin-like protease SBT3.17
- Membrane lipoprotein
- At1g01310 superfamily protein)
Sequence:
MIVYGGGASEDGEGGGVVLKKGPWTVAEDETLAAYVREYGEGNWNSVQKKTWLARCGKSCRLRWANHLRPNLRKGSFTPEEERLIIQLHSQLGNKWARMAAQLPGRTDNEIKNYWNTRLKRFQRQGLPLYPPEYSQNNHQQQMYPQQPSSPLPSQTPASSFTFPLLQPPSLCPKRCYNTAFSPKASYISSPTNFLVSSPTFLHTHSSLSSYQSTNPVYSMKHELSSNQIPYSASLGVYQVSKFSDNGDCNQNLNTGLHTNTCQLLEDLMEEAEALADSFRAPKRRQIMAALEDNNNNNNFFSGGFGHRVSSNSLCSLQGLTPKEDESLQMNTMQDEDITKLLDWGSESEEISNGQSSVITTENNLVLDDHQFAFLFPVDDDTNNLPGIC
Protein: CUB_2 domain-containing protein (Q95Y17)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKAAVGFMLIFYCISSTLGSYARMHSLRFYTNNTVPVKIECEDGSKIYLTSRDKVVQLAKITLTTSGVSTTLDKLLNSIDENAFLKGWPVNSDLTISTTNSESVTNTLHGELFVSTPTMAKDPNFLVRTVRGSQTIDRSTNSDTTIMFLAVYNPDRTGKPNYAPFNQVGVSNIVQPRGTNIYFYQAMPSDYYTDVTNVNTTRWNIFANPLMNVFASNPHNSFFDKIDPIQFSTSVWFRSTGGFKLDVSEAYVDTMSINSTSVSVTGMSNSQLFSNTSSVNFLSAGTNRLGYSGYILNTDMFATVNLTVQLSGQSGATDSYTTSGSQVNDDFHEVEWPAQSMQLIPSSIEMGLYYVQYFNMDTGAPTTTSAALSSTASTPSIASTATSAATNPPTTTAGASTNSPATNPPTTSRPITASQSTTSQNVETTTKLGLTASITVSMMITLLHNILFA
Protein: Hepatoma-derived growth factor (HDGF) (Q8VHK7)
Organism: Rattus norvegicus (Rat)
Function: Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P51858}. Cytoplasm {ECO:0000250|UniProtKB:P51858}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P51858}. Note=Secreted by exosomes and is located inside the exosome (By similarity). May also be secreted as free protein via an as yet unknown pathway (By similarity). {ECO:0000250|UniProtKB:P51858}.
Interaction partners:
- Pleiotrophin
- Midkine
Sequence:
MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCAEEPEVEPEAHEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGMLKRRAGDMLEDSPKRPKESGDHEEEEKEIAALEGERPLPVEMEKNSTPSEPDSGQGPPPEEEEGEEEAAKEEAEAQGVRDHESL
Protein: Ribosome biogenesis protein slx9 (Q9C0Z3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1) (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ankyrin repeat-containing protein P16F5.05c
- 20S-pre-rRNA D-site endonuclease nob1
- Ribosomal RNA-processing protein 7
- Casein kinase II subunit alpha
- Protein cms1
- Protein bud22
- rRNA biogenesis protein rrp36
- RNA cytidine acetyltransferase
- Pescadillo homolog
- Ribosomal RNA-processing protein 1 homolog
Sequence:
MPKAKKRVSLASKASSRLPSSGKPSQQASIPNVELSSTVTSNSQVLNNDPLKETKKDKRKDRHFNWQQKFSNPKISASARKRRNRKARENLKVNVSSIGEVLPEIDLDISVANSRLKPVIKDSLSSKQTKSSMKRNTVEEIERFQAILKHPSFVSNPLETVREHLGNSLDSR
Protein: Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7) (O15105)
Organism: Homo sapiens (Human)
Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Subcellular location: Nucleus {ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17327236}. Cytoplasm {ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17327236}. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). {ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17327236}.
Interaction partners:
- E3 ubiquitin-protein ligase SMURF2
- TGF-beta receptor type-1
- E3 ubiquitin-protein ligase NEDD4-like
- E3 ubiquitin-protein ligase SMURF1
- Transcriptional coactivator YAP1
- E3 ubiquitin-protein ligase Arkadia
- TGF-beta receptor type-2
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
- Transforming growth factor beta-1 proprotein
- Mothers against decapentaplegic homolog 6
Sequence:
MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHHHPHPPAAGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR
Protein: Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) (Q01105)
Organism: Homo sapiens (Human)
Function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
Subcellular location: Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium.
Interaction partners:
- Acidic leucine-rich nuclear phosphoprotein 32 family member A
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Nucleoside diphosphate kinase A
- Granzyme A
- Serine/arginine-rich splicing factor 6
- Exportin-1
- Nuclear pore complex protein Nup214
- DNA repair nuclease/redox regulator APEX1
- Shugoshin 2
- ELAV-like protein 1
Sequence:
MAPKRQSPLPPQKKKPRPPPALGPEETSASAGLPKKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD
Protein: Paralyzed arrest at two-fold protein 6 (Actopaxin homolog) (Parvin-like protein) (O16785)
Organism: Caenorhabditis elegans
Function: Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12781130}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:23283987}. Perikaryon {ECO:0000269|PubMed:12781130}. Cell projection, axon {ECO:0000269|PubMed:12781130}. Note=Colocalizes with integrins and pat-4/ILK (PubMed:12781130). Colocalizes to M line and dense bodies with cpna-1 (PubMed:23283987). {ECO:0000269|PubMed:12781130, ECO:0000269|PubMed:23283987}.
Interaction partners:
- Integrin-linked protein kinase homolog pat-4
- LIM domain-containing protein unc-97
- Paxillin homolog 1
- Protein unc-112
- Alpha-actinin, sarcomeric
- FERM domain-containing protein
- Vinculin
- SH3 domain-containing protein
- Integrin beta pat-3
- Ras suppressor protein 1
Sequence:
MSTLGRSKTPSRDEPKKPGVFEKLSGTLSRKKKAPEDEHGNQGGAHHATDEDEVLELELEGREALDQSLVPVLARNIWLEEGEIRRYLTKETARDQKLAQVVDLLIYWLNEELADQRIVVRHLQEDLFDGQIIQKLLEKLEQIRIEVPEVSQSEEGQRQKLQIVVQTANRILGQPREQEKWSADLIHQKDFTAIIQLLVLLALHYRAPVRFPDNVVANVVVAQKEHGQVKTHRITEQITTVQTELAPKGTRDAFDTLFDYGPDKLAHVKTSLLAFCNKHLNKINLEVSDLDNQFQDGVFLVLLVGLLEGYFVPLYHFNLQVQSHEEKVKNVQFAFKLMEDTGLEKPRSRVQDIANGDVKSTLRLLHLLFTKYKHI
Protein: Cytochrome c, somatic (P62897)
Organism: Mus musculus (Mouse)
Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Interaction partners:
- Caspase-9
- Apoptotic protease-activating factor 1
- Bcl-2-like protein 1
- Apoptosis regulator Bcl-2
- Caspase-3
- Non-selective voltage-gated ion channel VDAC2
- Apoptosis-inducing factor 1, mitochondrial
- Heat shock protein beta-2
- Diablo IAP-binding mitochondrial protein
- Cytochrome c1, heme protein, mitochondrial
Sequence:
MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE
Protein: Amphiregulin (AR) (Schwannoma-derived growth factor) (SDGF) (P31955)
Organism: Mus musculus (Mouse)
Function: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Subcellular location: Membrane; Single-pass membrane protein.
Interaction partners:
- Epidermal growth factor receptor
- Pro-epidermal growth factor
- Receptor tyrosine-protein kinase erbB-3
- Proepiregulin
- Receptor tyrosine-protein kinase erbB-4
- Protransforming growth factor alpha
- Receptor tyrosine-protein kinase erbB-2
- Epigen
- Probetacellulin
- Intercellular adhesion molecule 1
Sequence:
MRTPLLPLARSVLLLLVLGSGHYAAALELNDPSSGKGESLSGDHSAGGLELSVGREVSTISEMPSGSELSTGDYDYSEEYDNEPQISGYIIDDSVRVEQVIKPKKNKTEGEKSTEKPKRKKKGGKNGKGRRNKKKKNPCTAKFQNFCIHGECRYIENLEVVTCNCHQDYFGERCGEKSMKTHSEDDKDLSKIAVVAVTIFVSAIILAAIGIGIVITVHLWKRYFREYEGETEERRRLRQENGTVHAIA
Protein: Gamma-tubulin complex component (Q9GP63)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000256|RuleBase:RU363050}.
Interaction partners:
Sequence:
MAPPAQKGNLRKRSGKTSTAVNSAINENVRKLVRSLSEPGTSQKKLRQMEDTALKIIANQRRTWAPTTTDMEVKRNLDDLAERFRAEGMASFGESIKDLAIRYLAMDENQQQFNPNPGWQMLELLFRIADRPVQKIRLNREFMEQRRLSIINSMEEAERQAQIEEQAKLEAAKNTSETEVDWAALLSEDFLDPPEDDSSDSLSDWSEESDCDSTTTLKPDENIGVSRSLLEMARVYEQAMMAVVPTGSVNKTYMPPEQSVIRSYDFRIMKPTVLSLNNLKGSHLRRSKLLQLPPPQPPRPFTQYWQSGNTDTLFRKIHSHWWCQDVHLNALPSSAKPLDNFAVSYVQFLNHNARGLLALPVPKTITEPCLLREILFMFVRPASCCFFEFDKATRRITVRDNVSICTVTASTMQNFLLFNVVPALEDMMELRHIIDTHTLHFHGVKTTYTVEFFAYGLRDLVQPICQLLIAYEDRVNKDPAKNTLIRFTIEFREHFSQLRLLRELAEDVILDKGPAHIRSAYLLSRLYKHTLLQVPHQKLATALLFISLKRYCIIIDGWWRRAALEDHLREFIVEFCYEEDANTRSHVRKRNMGMEDDLLLVEIFNKLQSCPLYQLLLEHALESGETQDLLCSVNTLSEMLTSNNEIQLPSLHDELFTQFFAQLKVYCGADNTDYEDEPEPDKDYEDLTVCNRQGIRNHELFAIFTQPLVEQRLERQRERLKSNPVLMANILKRLERSTCLQLKSELPEALREILRRRQWLANEYAIRAYCKETQVAEKMRFLRHTMLLEKYYLFVPYYNALFVRMEKNNSWALGSVLTSKLCAVLLPHYPQLAHYLHVKLISQINSNSIKVYEALEAIELDFERPMAMHQWYILTPAHMQDYNSVWRLMLKVKWAVWKLENMQFLRRARFNPCAPLDLIGLTIRRLEIVRFWLIFLINNLHAHIMEAVSRQFELRIGECKNVRELRIMHDEHLAWLKTHCMLTDEFKAFRVALDQIFHLVYVLDMEWTTCASCMHDHDALCLDFTISDDGIDDSETQRRSLEYLALNQVAEIELTYIRCHQMLADILNTLVHQNDHGFLSALEETINSSVPH
Protein: dCTP deaminase, dUMP-forming (EC 3.5.4.30) (Bifunctional dCTP deaminase:dUTPase) (DCD-DUT) (P9WP17)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase. Affinity for dCTP and dUTP are very similar.
Interaction partners:
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- CTP synthase
- Nucleoside diphosphate kinase
- Cobalamin biosynthesis protein CobIJ
- Possible conserved exported protein
Sequence:
MLLSDRDLRAEISSGRLGIDPFDDTLVQPSSIDVRLDCLFRVFNNTRYTHIDPAKQQDELTSLVQPVDGEPFVLHPGEFVLGSTLELFTLPDNLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCMLRLTSPSEHPYGSSRAGSKYQGQRGPTPSRSYQNFIRST
Protein: Aquaporin (Q9V5Z7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Forms a water-specific channel.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Aquaporin
- Ribonuclease H1
Sequence:
MVEKTEMSKFVGVADITENKKIWRMLLGELVGTFFLIFVGVGSTTSGSVPQIAFTFGLTVATIAQGLGHLSGCHINPAVTLGFLIVGEISILKAAFYIIVQCVGAIAGAAVIKVALDGVAGGDLGVSSFDPSLNCAQAVLIEALITFILVFVVKAVSDPGRQDIKGSAPLAVGLAIAAGHLCAIKLSGASMNPARSFGPAVVQGVWTYHWVYWVGPIAGGLLAGIIYRLIFKVRKGDDETDSYDF
Protein: P-loop NTPase domain-containing protein LPA1 (Protein LOW PHYTIC ACID 1) (OsLpa1) (B9F4I8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Required for the accumulation of phytic acid in seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.
Interaction partners:
- Diphosphomevalonate decarboxylase
- diphosphomevalonate decarboxylase
- Molybdenum cofactor biosynthesis protein 1
- Molybdenum cofactor biosynthesis protein 1
- cyclic pyranopterin monophosphate synthase
Sequence:
MPMPPQCASSKPPSPPPPPHPHEHEVGDDMAEEAPPPPPPPKLLYIAVSDAAARRAFRYTRPVLQGTLQLMGCKARHAFKISKRVFNVMRSEFLDASKSDTADNEENAPSLVKDVEMLKPKILEATLSSIPFELYKTQTTIVVSREKFLSVVCDALSSYKYVGPNQKADFLLACRIKERKESVTVLLCGTSGCGKSTLSSLLGSRLGITTVVSTDSIRHMMRGFTDEKQNPLLYASTYHAGECLDPVAVAQAKAKRKAQKLDIVSHPNTNEGRDDTSDDKAHHGSSELPPRTELIGSKQMAIEGFKAQSEMVIDSLDRLITSWEEQKQSVIVEGVHLSLNFVMGLMKKHPSIIPFMVYIANEEKHMERFAVRAKYMTLDPAKNRYIKYIRNIRAIQDYLCNRADKHLVPKINNTNVDQSVAAIHATVFSCLRRREAGEQLYDLNTNTVAVVNEEYRNQRAANSLGSKGMFQLIQRQGSSRNLMAILNTDGSVTKAWHVDKNNGNGSLDGTSSDKSTKNPMYDTFGKAEPVNLQFGSFGISAWMSDTGGTSHTGSVDDLRADGIETGGRYYSSCCSSPKVSDCPSKELMEDDYSVFGSEEDADDPPDAGTDEDLTDEERDMHEIEAGSVDEHSTKSDEEYDDLAMQDVMENGYWSDDEQAASSTKNSSNQEKNIHGAADGDVVDDEGSGNDRFHHNLAFFLKMSKKVAATELPCA
Protein: Probable nudix hydrolase C6G9.05 (EC 3.6.1.-) (Q92350)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Interaction partners:
- Uncharacterized protein C1235.01
- Probable glutathione-independent glyoxalase hsp3104
- Putative uncharacterized oxidoreductase C1773.04
- Probable mitochondrial-processing peptidase subunit alpha
- Probable proteasome subunit beta type-5
- Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial
Sequence:
MKLKLRWKGHQRFLTRQNSLVGFIWSPLKNTFSKRNSILNNQVCFEAIKYIQRHYFSSQSHHVTYLHQSPLEKLVSNGVVNENGDLTMDSLSHQIYLLHKNRPTLPLKPTNQPTRFASVLMPLVNTSQGASLLLTQRSPNLRSHAGQMCFPGGRVEPSDGSHYYAALRETYEEIGFLPNFFTYLTTFPPLFTRDEKTEIRAYLAFSVQTSLPSLGTGEVKDLFYVPLTSFLNPKHQKISRFRNTDLLYVEFNIDKIPRIWGITAVILNMYLNSICPDALISIPKF
Protein: DnaJ protein ERDJ3A (Chaperone protein dnaJ C27) (OsDjC27) (Endoplasmic reticulum dnaJ domain-containing protein 3A) (OsERdj3A) (Q10MW6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May play a role in protein folding in the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:24153418}. Vacuole. Note=Localizes to the vacuole under ER stress. {ECO:0000269|PubMed:24153418}.
Interaction partners:
- Os01g0757900 protein
- Os02g0710900 protein
- Heat shock 70 kDa protein BIP1
- DnaK protein, expressed
- Heat shock 70 kDa protein BIP3
- Heat shock 70 kDa protein BIP2
- Os08g0487800 protein
- Heat shock 70 kDa protein BIP5
- Heat shock 70 kDa protein BIP4
- Heat shock protein 81-2
Sequence:
MGIPVRSLLVASIVLSSIALHVAAAKNLDPYKVLGVDKSASQRDIQKAFHKLSLKYHPDKNKSKGAQEKFAEINNAYDILSDEEKRKNYDLYGDEKGNPGFGGGNFGNREGYTYFTGGGAKTSHFSSGDGWQTMGGQGNTKTFSFSFGGGNPGAGGGNPFNFDFGDVFSNIFSGGSMGGSQHTGSAGKARRGTKSSGHDSSSVNIQEVTMQIFNKETADQGITWLLLFYTPNTKGQFVLESVVEDVARSLDGALRAGKVNCDHEKALCKKAGVSIGKSARLFIYSYTTTEKGSLHEYSGDYDSKSLKTFCQEHLPRFSKRVDINQFSFPSNIIPNLPQVLLLSAKKDTPAMWRAVSGMFRSRLIFYDAEVQDVSHPLLKSLGVKNIPALIGRSVNGEEQLLKDGISVKDLRSGIKELKNLLENFEKKNKKLASNQAKKPAHTDQPKENKIPLLTASNFEEICGEKTSVCILGIFKSSKAKENLEAVLSEISQKTLIRGQNYNSGNAVAYALLDGNKQSAFLSTFDKSAFKSSDKLLLAYKPRRGRYAVYDNEVTMEEAERFVVSVLNGDVQLSAAGRKPVLR
Protein: Mitochondrial apoptosis-inducing factor 1 transcript variant 1 (A0A068CA64)
Organism: Sus scrofa (Pig)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MFRCGGLAAGALKQKLAPLVRTVCVRGPRQRNRLPGHLFQRWHVPLELQMTRQMASSGASGGKIDNTVLVLFVGLSTIGAGAYAYRTIKDNKKRYNERIAGLGLTPEEKQKRATSSAPEGEPVPQVRVPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFRQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRGNMAKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRTLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVLPNAIVQSVGVSGGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEAPEITLPVGSPAVPQAPTQGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED
Protein: Platelet-derived growth factor (PDGF) family profile domain-containing protein (Q9N413)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein ver-1
- Tyrosine-protein kinase receptor ver-4
- Kringle domain-containing protein
- Furin-like protease kpc-1
Sequence:
MQNPMILLIFCLFCAVICSRGTDSDIPHEFHKMLKHAKSLNSLLRDLHVIYSPEMTNRHVEKTDKHGAALSLKSGSMSAQRIVSIQNISDDEMDGYTLFHLQSMKDIKQGNDTCNLQSVCVPIPQLSDDPQVLMYPKCYEVKQCVGSCCNSVETCHPGTINLVKKHVAELLYIGNGRFMFNMTKEITMEEHTSCSCFDCGSNTPQCAPGFVVGRSCTCECANKEERNNCVGNATWNAETCKCECDLKCEEGKILHKDRCDCVRRRQHHGGPRGHHGHRHHHRSRPIDTEEVQKIGQLKVGRIGG
Protein: RRN3 homolog, RNA polymerase I transcription factor (F5H148)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAPLLHTRLPGDAAASSSAVKKLGASRTGISNMRALENDFFNSPPRKTVRFGGTVTEVLLKYKKGETNDFELLKNQLLDPDIKRLPWLNRSQTVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDDNLPANFDTCHRALQIIARYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVNASRQGIEDAEETATQTCGGTDSTEGLFNMDEDEETEHETKAGPERLDQMVHPVAERLDILMSLVLSYMKDVCYVDGKVDNGKTKDLYRDLINIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNNQDSGTKAFCDVALHGPFYSACQAVFYTFVFRHKQLLSGNLKEGLQYLQSLNFERIVMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTIIERNNRQMLPVIRSTAGGDSVQICTNPLDTFFPFDPCVLKRSKKFIDPIYQVWEDMSAEELQEFKKPMKKDIVEDEDDDFLKGEVPQNDTVIGITPSSFDTHFRSPSSSVGSPPVLYMQPSPL
Protein: Homeobox protein MOX-1 (Mesenchyme homeobox 1) (P32442)
Organism: Mus musculus (Mouse)
Function: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:22206000}. Cytoplasm {ECO:0000269|PubMed:22206000}. Note=Localizes predominantly in the nucleus. {ECO:0000269|PubMed:22206000}.
Interaction partners:
- T-box transcription factor TBX6
- Transcription factor 15
Sequence:
MDPVANSCVRNPQPPAPVWGCLRNPHSEDSSASGLSHYPPTPFSFHQKSDFPATAAYPDFSASCLAATPHSLPRTERIFNEQHPAFPQTPDWHFPISEAGQRLNLGPAGSAREMGAGSPGLVDGTAGLGEDCMVLGTIANETEKKSSRRKKERSDNQENGGGKPEGSSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVWFQNRRMKWKRVKGGQPVSPQEQDREDGDSAASPSSE
Protein: Large ribosomal subunit protein mL60 (54S ribosomal protein L31, mitochondrial) (Negative regulator of cdc42 protein nrf20) (Q9UR27)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein uS11m
- Large ribosomal subunit protein uL5m
- Small ribosomal subunit protein mS45
- Small ribosomal subunit protein uS4m
- 3,4-dihydroxy-2-butanone 4-phosphate synthase
- Diaminohydroxyphosphoribosylamino-pyrimidine deaminase
- Inositol phosphorylceramide synthase regulatory subunit kei1
Sequence:
MLGAFNSTLARFGGLVHKVPWRLSQRRKYRHRQRLRAVDEVVDVLRTALQEKNQSCKRIESFVANHQPESQMSPKDKYTMFTRKTQGAGLQGFRKGVHKSPKWTRSTNRVNPTGF
Protein: Protein XRP2 (F1QC45)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane (By similarity). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization (By similarity). In the retina, required for maintenance of rod and cone photoreceptor cells. May have a role in normal retinal localization of the transducins GNB1 and GNAT1, and the rhodopsin kinase GRK1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26034134}; Lipid-anchor {ECO:0000250|UniProtKB:O75695}; Cytoplasmic side {ECO:0000250|UniProtKB:O75695}. Cell projection, cilium {ECO:0000250|UniProtKB:O75695}.
Interaction partners:
- ADP-ribosylation factor-like protein 3
- Protein unc-119 homolog B
- ADP-ribosylation factor-like 2
- FMRFamide related peptide 1
- ADP-ribosylation factor-like protein 3
- Protein unc-119 homolog A
- Protein unc-119 homolog A
- ADP-ribosylation factor-like protein 3
- Tubulin-specific chaperone D
- ADP-ribosylation factor-like protein 3
Sequence:
MGCFFSKKSRRKSPKKDAALPTGDESATGNDLAETNNTALGSNSNQEAPKQYSWDKREKVDPKDFMLTGLKNETVGRLPGKLNGQQFVIQDCENCNIFVLDHSATITIDDCVNCRIVLGPVKGSVFFRDCKDIKCVVACQQFRTRDCKKMDVFLCCATQPIIESSTGMKFGCFQYYYPELAFHFKDAGLSIFNNNWSNIHDFTPVSGETNWSLLPEDAVVLDHVPLPDPESEFKSVRIATEAGRSIVPLTKGSRRTESEESCLFVFFAGDYTTANARKLIDEATAKGFVLIQTKEVSMRPEDVSRVFQNNAESLTEWITKGPVVALELNGDGVVEACRSFANEVFNGTQLFVSESKNTSSRDVDNFFNFADMQMGL