wanglab/gogpt-training-data huggingface dataset:
Protein: Reticulon-4 receptor precursor (Reticulon-4/Nogo receptor) (Q6X3Y5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MKTLIVEGGRLLCLMFWLNLVPVINSCPAKCVCYSEPKATVACQQQGLFSIPTEIPVRSQRIFLQSNKLTVVRSTSFSSVHNLTVLWMYSNNISHIEAGAFYGLERLEELDIGDNSNLRIISPTAFRGLTKLHTLHLHRCGLSELPVGVFRGLFSLQYLYLQDNNLLALHEDTFLDLANLTYLFLHNNKIKVVTDHMLRGLVNLDRLLLHQNRIVHVQQQAFNDLSKLTTLFLFFNNLTMLTGESMNPLVSLQYLRLNGNQWICDCRARPLWDWFKRFKGSSSDLECHLPASLNGKDLKRLKSDDLEGCVDSPSQVQTSIFNSKVHSGKFLSLDDPLVESIPRCCLSDNDKSSIISSKSIPDPSSYNSRQITNNPLKEKENISKTKFREVERTKNETRNKQSLNDGPLGTMSNNLDQSLDRIDPELLGNLEPSTAPTKKKKKCSKKPKSDQNCLKGHGSTIQVLAVIFLPLFWLSLALS
Protein: RE21455p (WD repeat domain 62, isoform B) (Q0E8U6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFAPRNSSPVAIYGKEDVAAYEIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRKYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQTLPEECFVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSEIEQPQLQPKFGVAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNVQTSDYNSASSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSENLPQSSTNSFLHAALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEELLQVINKVKQQLENVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQKPGNPKTLNPMPIEESSIRRACSLSDLHMGNFGKPGKSQNGTPQKPQVQHRNGNVSRSASKRNSLQGKTGLGASSNSMNVLNQGSDSEPEDSNRLRSASNGQGRSNGPIAANRQYSNKINNVNNNRRKTPNFSSATPMQDDSSSEETPNSTVNNKPIVPPRPRNLAFDHKSKLMINNSGSPGGNAKQRSGVTSTEDFEGTDPEAQVHNVINKLYTTTQAAMQLHANLKNTLLLKELENALIMSRNMLSSITNRQADKTNNGGGGLGVGGSGGLNHDQLNADNGDYLMMVNNCADLLSNLRTKHKPDDCENNS
Protein: Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) (Q91WN4)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
Subcellular location: Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03018}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018}.
Interaction partners:
- Kynureninase
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
- Kynurenine formamidase
- 3-hydroxyanthranilate 3,4-dioxygenase
- Kynurenine--oxoglutarate transaminase 1
- Kynurenine--oxoglutarate transaminase 3
- Tryptophan 2,3-dioxygenase
- 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Indoleamine 2,3-dioxygenase 1
Sequence:
MASSDTQGKRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVAKSARGRSINLALSYRGRQALKAIGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISRENLNKDLLTAVESYANAKVHFGHKLSKCIPEEGVLTVLGPDKVPRDVTCDLVVGCDGAYSTVRAHLMKKPRFDYTQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAYMMIALPNMDKSFTCTLFMPFEEFERLPTRSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSHCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNNLSMCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQKLLDKFLHAIMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLIAIGGTYLLVHHLSLRPLEFLRRPAWMGTTGYWTRSTDISLQVPWSY
Protein: Fanconi-associated nuclease 1 homolog (EC 3.1.4.1) (P90740)
Organism: Caenorhabditis elegans
Function: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y2M0}.
Interaction partners:
- FANCD2
- DNA mismatch repair protein S5 domain-containing protein
- Mismatch repair endonuclease PMS2
- Crossover junction endonuclease MUS81
- FANCI helical domain-containing protein
- DNA repair endonuclease XPF
- Structure-specific endonuclease subunit SLX1 homolog
- ERCC1-like central domain-containing protein
- DNA polymerase kappa
- ATP-dependent helicase wrn-1
Sequence:
MKKAKKEKKEKIIKPDGPINFNRSIMAAFEKQSRGKICPLCETKFSLASYKSHMNTCNVADDDEEIEVIATYTRDEAILMRAGPEIILGDASFSDKSENPTKRRKTDEREVPSEDDIVPEVPGPSGIVKNHEMPSESLDVTEISENIEKVIKKSPEWINHRRRSSRLLQNSQKDQADNANKEDPVKKETATISEVLQAIERFEQRVSGPEQTWPYYIKITIKIMKRVISTEKFDGTFYADDFWLPSDIITFYRFVELLSEGAKCLLVRLFIRKPAWYNLEKLEQKYPEIPNIKEAVSELAKGHFIDDDSSMKTLDEALQISDVVALKNVTKKFKLDGTKNRQELIQSLRKFAQSQQSIFGGTGNVEKSILKSLKQELGPCVRVRGGFVDLFKCLFTIYCPVTTNSANVIDNPSTTNVYQDLLYLMLSVANGTVQFPAPNPCPIIASFYKNRNMLQDYMISKSLEIAIVSQMSNGNLDAALDLAIDAKEFIEQMSDDDKRYYESLEIHERKFTSIWVFTRCCGHASSILERQKKYGMAVEWQKDLLITNKDIQSYCIDSRGIWWDRMLLNLDSHLKEKKECAKMIQIALQDPSILEKELLMIQDRALKLKEMPADFVTPINIGNPEKKTITANVITKSLGDGRINRFMIRDHETDDDVECSVEEVTRRHYLENEGFSTGVHDEGSTWHTLFGLFFYDVIFATDESVESTWLSELQDCPSDLSNTLYSKRKEKFEDRFVWLEEAEQELIEENIRKIWDLKHNETNRECSWKQFPMGAEDCVSFFQCIPRPALILILRRLAENYRNSRSGFPDLTLWNPETKRVAVVEVKGPGDRLSTKQRLWLAIFADSGIRAEVCHVAAQNSRLLV
Protein: Putative deoxyribonuclease TATDN3 (EC 3.1.21.-) (Q3U1C6)
Organism: Mus musculus (Mouse)
Function: Putative deoxyribonuclease.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein transport protein Sec61 subunit alpha isoform 2
Sequence:
MGLGLVDCHCHLSASDFDNDLDDVLEKARKANVMALVAVAEHAGEFERIMQLSERYNGFVLPCLGVHPVQELSPEKPRSVTLKDLDVALPIIEKYKDRLLAIGEVGLDFTPRYAGTDEEKEEQRQVLIRQVQLAKRLNVPLNVHSRSAGRPTISLLREQGAEQVLLHAFDGRPSVAMEGVRAGYYFSIPPSIVRSGQKQKLVKQLPLSSICLETDSPALGPEKLTRNEPCNISIAAEFIAQVKGISVEEVREVTTRNAFRLFPKLQSLLQKELQSHPLQAKSAQGSAGESKGLL
Protein: Spliceosome RNA helicase Ddx39b (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein Uap56) (Q63413)
Organism: Rattus norvegicus (Rat)
Function: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.
Subcellular location: Nucleus. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Can translocate to the cytoplasm in the presence of MX1. {ECO:0000250}.
Interaction partners:
- Aly/REF export factor
- SAP domain-containing ribonucleoprotein
- THO complex 3
- THO complex subunit 5 homolog
- THO complex subunit 2
- Chromatin target of PRMT1 protein
- THO complex subunit 1
- THO complex subunit 7
- THO complex subunit 6 homolog
- THO complex subunit 1
Sequence:
MAENDVDNELLDYEDDEVETAAGADGTEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR
Protein: Large ribosomal subunit protein uL2m (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2) (Q9D773)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q5T653}.
Interaction partners:
- Large ribosomal subunit protein bL17m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL4m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS15m
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein uL13m
- Small ribosomal subunit protein bS16m
Sequence:
MALCALTSALRSLSLASAAITARVPTLLPAAQIQSNVLLQLPPALVSPSYRPVHMSADRSAKFVSWKSRTKYTVKPVKMRKSGGRDHTGRIRVHGIGGGHKQNYRMIDFLRFRPEKEKAPEPFEEKVVVVRYDPCRSADIALVAGGSRKRWIIATENMKAGDTILNSNHIGRMAVAAQEGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGTCGVLLRKVNGTAIIQLPSKRQMQVLESCTATVGRVSNVNHNQRVIGKAGRNRWLGKRPNSGLWQRKGGWAGRKIRPLPPMKSYVKLPSAAAQN
Protein: Alpha1,4-galactosyltransferase 1 (EC 2.4.1.-) (GH17972p) (Q9VQK4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Interaction partners:
- Alpha1,4-galactosyltransferase 2
- Alpha-galactosidase
- beta-N-acetylhexosaminidase
- beta-N-acetylhexosaminidase
- Beta galactosidase, isoform A
- Beta-galactosidase
- Uncharacterized protein, isoform A
- Hemolectin, isoform A
- Nidogen
- Beta1,4-N-acetylgalactosaminyltransferase B
Sequence:
MLLWLPIAVARRMFIILVLMVIGGLFYIYTSENKYHSCFMEGQVLATQQALTADGETNLLGDVLQADPKPSPGNSIFFHETSCRLSENRQLETLKVTARQACAIESAAMHNPNFQVFVLFAGPTYRISNNKSHPQPLLEAILSYSNVHLRRLNLESYASGTPMEEWLKDGRLSRSKYLFSHISDFLRYLTLYRYGGLYLDMDVVVLRNMEKVPPNYTGAESNTHLAAGVMNLAATGFGHEIAASCLRDFQHNFNGGDWGNNGPGVITRVAQKICGTKDIALMREDPKRCMGFKVFGRGAFYAVPWKQWRDFFEPENLEETIARCKDSYVVHVWNKHSSKLPIKIGSKNAYALYAEQNCPRSYKAAGEYF
Protein: Small ribosomal subunit protein uS8c (30S ribosomal protein S8, chloroplastic) (P0C494)
Organism: Oryza sativa subsp. japonica (Rice)
Function: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS2c
- Small ribosomal subunit protein uS11c
- DNA-directed RNA polymerase subunit alpha
- Small ribosomal subunit protein uS9
- Os10g0411700 protein
- 40S ribosomal protein S29, putative, expressed
- Small ribosomal subunit protein uS14c
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein uS4c
- Large ribosomal subunit protein uL14c
Sequence:
MGKDTIADLLTSIRNADMNKKGTVRVVSTNITENIVKILLREGFIESVRKHQESNRYFLVSTLRHQKRKTRKGIYRTRTFLKRISRPGLRIYANYQGIPKVLGGMGIAILSTSRGIMTDREARLNRIGGEVLCYIW
Protein: Cellular communication network factor 6 (WNT1 inducible signaling pathway protein 3) (D0E2W2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Acid sphingomyelinase-like phosphodiesterase.
Sequence:
MMLSLLCWFLLIFLSRGADSRREGTGPADKRQFCSWPCKCGVRPLCAPGVSSILDGCGCCKTCAQQIGESCNERDICDPHKSMYCDFSKDQPRYEVGICAYLMGVGCDLNGAHYDNGQAFQPNPLYKCTCISGSIGCTPAFIQKPTGMLSPAALQGQLPAGLKSSRNPKNQQDTTYRTMSAYRDPPLAWKKNCLVQTTAWSPCSRSCGIGISVRVNNDNSKCEMRKERRLCLLRPCDKNTLKRLKMPKGKTCKPKFQASKAEKLSLSGCTSVKKHRPTYCGVCTDKRCCVPNKSKMVNVEFHCKGGSNVRWKMQWITSCVCQRKCSNADDMFSELHLI
Protein: HIPL1 protein (Q9SSG3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Putative U-box domain-containing protein 50
- Putative F-box protein PP2-B6
- Xanthotoxin 5-hydroxylase CYP82C4
- Jacalin-related lectin 12
- Protein PHR1-LIKE 1
- Receptor like protein 24
Sequence:
MKLHQFLVFLFLFLSCFALSSWALPLCSDSRAPSEVNSTLSFCPYKGKTCCNTMKDTSLMKQFQAMNISDKGCASVVKSILCANCDPFSSDLFRDNSDQQSVPILCNSTSSANSTENFCSETWETCQNVSISGSLFAASLQGRAGAPSNKNASKLADLWQSKTDFCSAFGGASSNETVCFSGEPVALNDNDTTPDKPPSGICLEKIGNGSYLNMVPHPDGSNRAFFSTQPGIVFLAGIPDQDSGGVLDVDPSSPFVDMTDEIHFDTEFGMMGMAFHPKFAQNGRFFASFNCDKSKWPGCTGRCSCNSDVNCDPSKLTPDSGSQPCQYQTVIAEYTANSTSSDPSKAKNAKPTEVRRIFTMGLPFTSHHAGQILFGPDGYLYFMMGDGGGGADPYNFAQNKKSLLGKIMRLDVDNIPSASEISKMGLWGNYSIPKDNPFREDKELEPEIWAVGLRNPWRCSFDSSRPSYFMCADVGQDTYEEVDLISKGGNYGWRVYEGPDLFHPESSPGGNTSVKSLNPIFPVMGYNHSEVDSSGKSASITGGYFYRSETDPCIAGRYVYADLYGNGVWAGIETPANSGSFVTKRTTFSCASDSPMKCSDSPGTSGLSLGYVFSFGEDNNKDIYLLTSNGVYRVVRPSRCNLTCSKENSTARRNPGTSSSPSSSSSSCYKHINGFHGSLVVLFVSLSLILLGLLN
Protein: E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) (Q9HCE7)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Plays a role in dendrite formation by melanocytes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21572392}. Cell membrane {ECO:0000269|PubMed:21572392}; Peripheral membrane protein {ECO:0000269|PubMed:21572392}; Cytoplasmic side {ECO:0000269|PubMed:21572392}.
Interaction partners:
- Mothers against decapentaplegic homolog 6
- Mothers against decapentaplegic homolog 7
- Mothers against decapentaplegic homolog 1
- Mothers against decapentaplegic homolog 5
- TGF-beta receptor type-1
- Transforming protein RhoA
- E3 ubiquitin-protein ligase SMURF2
- Runt-related transcription factor 2
- TGF-beta receptor type-2
- Mothers against decapentaplegic homolog 2
Sequence:
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
Protein: Melanoma-associated antigen D1 (Dlxin-1) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Q9QYH6)
Organism: Mus musculus (Mouse)
Function: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed.
Subcellular location: Nucleus {ECO:0000269|PubMed:20300063}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 16
- E3 ubiquitin-protein ligase Praja-1
- Netrin receptor UNC5A
- UBX domain-containing protein 1
- FAS-associated factor 2
- Neuronal PAS domain-containing protein 4
- Homeobox protein DLX-5
- E3 ubiquitin-protein ligase XIAP
- Protein AATF
- Neurotrophin receptor-interacting factor 1
Sequence:
MAQKPDGGAGLRGFQAEASVEDSALLVQTLMEAIQISEAPPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNATTKGPNDYSQARNAKEMPKNQSKAAFKSQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANEMTNNQPKTAKAWNDTTKVPGADAQTQNVNQAKMADVGTSAGISEADGAAAQTSADGSQTQNVESRTIIRGKRTRKVNNLNVEENNSGDQRRASLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWPFPPDWIPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGIIFMNGNRATEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARNRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQAFTGPIIGPSGTATANFAANFGAIGFFWVE
Protein: DEAD-box ATP-dependent RNA helicase 16 (EC 3.6.4.13) (Q9SW44)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transducin/WD40 repeat-like superfamily protein
- Ribosome production factor 2 homolog
- Protein SLOW WALKER 2
- Peter Pan-like protein
- DEAD-box ATP-dependent RNA helicase 13
- Expressed protein family protein)
- Probable rRNA-processing protein EBP2 homolog
- Pescadillo homolog
- Ribosome biogenesis protein WDR12 homolog
- Ribosome biogenesis protein BOP1 homolog
Sequence:
MGKTKLKPVEDVNSEVVDEVEKAEEVEEQRNDREQEEEQKEEEAPKSFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKLAPSAFILVPSRELCQQVYTEVSSLIELCRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPTAVSESLSILVLDEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLTLTEDNDKEEAVPSNVQQFWISCSAQDKLLHILALLKLEVVQKKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATDDNSQTKKQKEEAKGEANKENKKNNKRSKPKLDAEFGVVRGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRAYSSGSSVSLISPDEMEGFEDIKSFLASDKNKDIDIITPFPLLTENAVESLRYRAEDVAKSVTKIAVRESRAQDLRNEIINSEKLKAHFEANPRDLDLLRHDKPLSKTAPAPHLKDIPEYLVDAKTQEASKMVKLARAAMGNTRRSGGGGGRNNKNKKRSRKGSDPLKTFNPNGSKRGAVGQKDGKDSSSTKKQKTV
Protein: Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) (P15473)
Organism: Rattus norvegicus (Rat)
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P17936}. Nucleus {ECO:0000250|UniProtKB:P17936}.
Interaction partners:
- Insulin-like growth factor 2
- Insulin-like growth factor 1
- Insulin-like growth factor-binding protein complex acid labile subunit
- Receptor protein-tyrosine kinase
- Insulin-like growth factor-binding protein 5
- Insulin-2
- Insulin-like growth factor 1 receptor
- Insulin-1
- Insulin-like growth factor-binding protein 6
- Retinoic acid receptor RXR-alpha
Sequence:
MHPARPALWAAALTALTLLRGPPVARAGAGAVGAGPVVRCEPCDARALAQCAPPPTAPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLKALLNGRGFCANASAASNLSAYLPSQPSPGNTTESEEDHNAGSVESQVVPSTHRVTDSKFHPLHSKMEVIIKGQARDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYDTKGKDDVHCLSVQSQ
Protein: CHK2 checkpoint homolog (S. pombe) (Serine/threonine-protein kinase Chk2 (EC 2.7.11.1)) (Q803E2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSEEAGPSGESQSQTQSQTQSQPASSSSSAPTSSSQGSSSGSGTLSSVDTVPVQELQSIPEDEEEVQPQVWGRTIPLKQGFSVLNCTENQYSFGRDKRCDYSFSNSILKKSPYFNTYSKKHFRIFRDENLVYLEDLSGNGTWVDDEKLGNGKQSLLGNNSVIALAEQKHQVFMFIDKMADDQANLPLEFSKKYHIARKIGTGVCGEVKLAIEKETFKKVALKTINKHDFPSIGTATRNAEREIEILKKIDHPCLIKTEDFYQTEDSYYIVLEYIEGGELFGRIKAKKKLEEDIAKLYFYQMLKAVEYLHNNGIIHRDLKPENVLLASHDDICLIKITDFNQSKILEESSLMKTLCGTPTYVAPEVFTHASTVGYTKAVDYWSLGVLLFICLGGYPPFNTECTTMSVREQIINGEYRFIPSQWKNVSNEAKDLVKKLLVVDPQKRLSVEEALEHPWLKDDRMRQNANQLMNPGAANQPMRPEATRKRKAQEGEGEPSSKRKPGP
Protein: Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5) (B1AYB6)
Organism: Mus musculus (Mouse)
Function: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro) (By similarity).
Subcellular location: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q9P267}. Chromosome {ECO:0000250|UniProtKB:Q9P267}. Note=Associates with heterochromatin containing chromocentres in a DNA methylation-independent manner. Does not localize to sites of DNA damage. {ECO:0000250|UniProtKB:Q9P267}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000250|UniProtKB:Q9P267}. Note=Does not associate with heterochromatin containing chromocentres. Does not localize to sites of DNA damage. {ECO:0000250|UniProtKB:Q9P267}.
Interaction partners:
- Putative Polycomb group protein ASXL2
- Ubiquitin carboxyl-terminal hydrolase BAP1
- Lysine-specific histone demethylase 1B
Sequence:
MNGGKECDGGDKEGGLAAIQVPVGWQRRVDHNGVLYISPSGSLLSCLDQVKTYLLTDGTCKCGLECPLILPKVFNFDPGAAVKQRTAEDVKADDDVTKLCIHKRKIIAVATLHQSMEAPHPSLVLTSPGGGTNATPVVPSRAATPRSVRNKSHEGITNSVMPECKNPFKLMTGSSNAMGRLYMQDLPGSQQQELHPVYPRQRLGSSEHGQKSPFRGSHGGLPSPASSGSQIYGDGSISPRTDPLGSPDVFTRNNPGFHGAPNSSPIHLNRTPLSPPSVMLHGSPVQSSCAMAGRTNIPLSPTLTTKSPVMKKPMCNFSTNMEIPRAMFHHKPPQGPPPPPPPSCALQKKPLTSEKDPLGILDPIPSKPVNQNPIIINPTSFHSNVHSQVPVMNVSMPPAVVPLPSNLPLPTVKPGHMNHGSHVQRIQHSASTSLSPSPVTSPVHMMGTGIGRIEASPQRSRSSSTSSDHGNFMMPPVGPQATCSGIKVPPRSPRSTIGSPRPSMPSSPSTKSDGHHQYKDIPNPLIAGMSNVLNTPSSAAFPTAPAGNGSVKSQPGLLGMPLNQILNQHNAASFPASSLLSAAAKAQLANQNKLAGNNSSSSNNSGAVASSGNTEGHSTLNTMFPPTANMLLPTGEGQSGRAALRDKLMSQQKDSLRKRKQPPTTVLSLLRQSQMDSSAAPKPGPDLLRKHGQGSFPISSMSQLLQSMSCQSSHLSSNSTPGCGGSNTALPCSANQLHFPDPNMNSTVLQNSLTQSIPLRGEAVHCHNANTNFVHSNSPVPNHHLAGLINQIQASGNCGMLSQSGMALGNSLHPNPPQSRISTSSTPVIPNSIVSSYNQTSSEAGGSSLPSSIAIAGSNHPAITKTTSVLQDGVIVTTAAGNPLQSQLPIGSDFPFVGQEHALHFPSNSTANNHLPHPLNPSLLSSLPISLPVNQQHLLNQNLLNILQPSAGEGDISSINNSLNNHQLTHLQSLLNSNQMFPPNQQPQQHLLQGHQNLQAFQGQPTVPCPANNNPMACLFQNFQVRMQGDAALLNKRISTQPGLTTLPENPNLALPHFQDTPCELQPRIDLGQPMKDGLVMGGQGDASVDAIYKAVVDAASKGMQVVITTAVNSTTQISPIPALSAMSAFTASIGDPLNLSSAVSAVIHGRNMGGVDHDGRLRNARGARLPKNIDHGKNSSEGDGFECFKSASCHTSRKQWDGEQSPRGERNRWKYEEFLDHPGHIHSSPCHERPNNVSTLPFLAGEQHPILLPPRNCQGDKILEENFRYNNYKRTMMSFKERLESTVERCTHINGNRPRQSRGFGELLGTAKQDLVLEGQSPGSSNSLESSLVKDYIHYNGDFNAKTINGCVPSPSDAKSISSEDDLRNPDSPSSHELIHYRPRTFNVGDLVWGQIKGLTSWPGKFIREDDVHNSCQQSPEEGKVEPEKLKTLTEGLEAYSRVRKRSRKSGKLNNHLEAAIHEAMSELDKMSGTVHQIPQGDRQMRPPKPKRRKISR
Protein: Cleavage and polyadenylation specificity factor subunit 5 (Q93716)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR017888}. Cytoplasm {ECO:0000256|PIRNR:PIRNR017888}.
Interaction partners:
- RRM domain-containing protein
- Pre-mRNA polyadenylation factor Fip1 domain-containing protein
- Cleavage and polyadenylation specificity factor subunit 4
- Polycomb group RING finger protein 3 homolog mig-32
- Protein mago nashi homolog
- PWWP domain-containing protein
- RRM domain-containing protein
- Chromatin target of PRMT1 protein C-terminal domain-containing protein
- Cleavage stimulation factor 50 kDa subunit
- Polyadenylation and cleavage factor homolog 11
Sequence:
MEDIWPTIERTTISASVPEAPANFDEKPPFNRTINVYPLTNYTFGTKDAQAEKDKSVPERFKRMKDEYEVMGMRRSVEAVLIVHEHSLPHILLLQIGTTFYKLPGGELELGEDEISGVTRLLNETLGRTDGETNEWTIEDEIGNWWRPNFDPPRYPYIPAHVTKPKEHTKLLLVQLPSKSTFCVPKNFKLVAAPLFELYDNAAAYGPLISSLPTTLSRFNFIFNDSN