wanglab/gogpt-training-data huggingface dataset:
Protein: Large ribosomal subunit protein uL14B (60S ribosomal protein L23-B) (L17a) (YL32) (P0CX42)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}.
Interaction partners:
Sequence:
MSGNGAQGTKFRISLGLPVGAIMNCADNSGARNLYIIAVKGSGSRLNRLPAASLGDMVMATVKKGKPELRKKVMPAIVVRQAKSWRRRDGVFLYFEDNAGVIANPKGEMKGSAITGPVGKECADLWPRVASNSGVVV
Protein: Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform (AtB' alpha) (PP2A, B' subunit, alpha isoform) (O04375)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Required for the formation of the PP2A holoenzyme that positively regulates brassinosteroid signaling by dephosphorylating and activating BZR1.
Subcellular location: Nucleus {ECO:0000269|PubMed:26517938}. Cytoplasm {ECO:0000269|PubMed:26517938}.
Interaction partners:
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''epsilon
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine protein phosphatase 2A regulatory subunit B''beta
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine protein phosphatase 2A regulatory subunit B''alpha
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''delta
- Serine/threonine-protein phosphatase PP2A-4 catalytic subunit
- Probable serine/threonine protein phosphatase 2A regulatory subunit B''gamma
Sequence:
MFKKIMKGANRKASKAEANDSSMYGFDPPGRSGPGSNMIVNHASRGSLVPSSPNSMAAATTQPPPMYSVEPLPLFRDVSVSERQSLFLRKLQICCFQFDFTDTLKNAREKEIKRQTLLELVDFIQSGAGKLTEVCQEEMVKMISVNIFRCLPPASHENTGQEPADLEEEEPYLEPSWPHLQLIYELLLRYIVPSDTDTKVAKRYIDHSFVLRLLELFETEDPREREYLKTILHRIYGKFMVHRPFIRKAMNHIFYRFIYETERHSGIGELLEILGSIINGFALPMKEEHKLFLIRALIPLHKPKPIAMYHQQLSYCIVQFVEKDYKLADTVIRGLLKFWPVTNCTKEVLFLGELEEVLEATQTVEFQRCMVPLFQQIARCLSSSNFQVAERALFLWNNEHVVGLIAQNRGVILPIIFASLEKNIESHWNQAVHGLSANIKRMFMEMDPELFEECQQQYEEKQAKSKQVEEQRQNRWRRLDEAVEEREREDPMITS
Protein: Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) (Q9JLI4)
Organism: Rattus norvegicus (Rat)
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivate expression in an agonist- and AF2-dependent manner. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Retinoblastoma-binding protein 5
- Protein dpy-30 homolog
- WD repeat-containing protein 5
- [histone H3]-trimethyl-L-lysine
- PAXIP1-associated glutamate-rich protein 1
- Bystin
- Protein AATF
- 5'-AMP-activated protein kinase subunit gamma-1
- Pre-rRNA-processing protein TSR1 homolog
Sequence:
EQIMTNQMQGNKAQFNSQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVSNSPSQVMGIQGQVLRPPGPSPHMAQQHTDPATTANNDVNLSQMMPDVSMQQTSMVPPHVQSMQGNSASGSHFSGHGVSFNAPFGGAPNGTQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKQKKKKPPRKKKNCHQDLNTPDSRPAGLEEVDQQSLPGEQGINLDNTGPKLPDFSNRPPGYPTQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQPQPQPPPPSQPQSQQQQQQQQQQQQQQMMMMLMMQQDPKSIRLPVSQNVHPPRGPLNPDSQRVPMQQSGNVPVMVSLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNSSS
Protein: 9,13-epoxylabda-14-ene synthase, chloroplastic (EC 4.2.3.189) (Manoyl oxide synthase) (EC 4.2.3.190) (Miltiradiene synthase) (EC 4.2.3.131) (A0A075FBG7)
Organism: Marrubium vulgare (White horehound)
Function: Involved in the biosynthesis of labdane-type diterpenoid including marrubiin and other labdane-related furanoid diterpenoids with potential applications as anti-diabetics, analgesics or vasorelaxants (Probable). Terpene synthase the catalyzes the conversion of peregrinol diphosphate to 9,13(R)-epoxy-labd-14-ene, from (+)-copalyl diphosphate ((+)-CPP) to miltiradiene and from 8-hydroxycopalyl diphosphate (LPP, labda-13-en-8-ol diphosphate) to manoyl oxide.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MSITFNLKIAPFSGPGIQRSKETFPATEIQITASTKSTMTTKCSFNASTDFMGKLREKVGGKADKPPVVIHPVDISSNLCMIDTLQSLGVDRYFQSEINTLLEHTYRLWKEKKKNIIFKDVSCCAIAFRLLREKGYQVSSDKLAPFADYRIRDVATILELYRASQARLYEDEHTLEKLHDWSSNLLKQHLLNGSIPDHKLHKQVEYFLKNYHGILDRVAVRRSLDLYNINHHHRIPDVADGFPKEDFLEYSMQDFNICQAQQQEELHQLQRWYADCRLDTLNYGRDVVRIANFLTSAIFGEPEFSDARLAFAKHIILVTRIDDFFDHGGSREESYKILDLVQEWKEKPAEEYGSKEVEILFTAVYNTVNDLAEKAHIEQGRCVKPLLIKLWVEILTSFKKELDSWTEETALTLDEYLSSSWVSIGCRICILNSLQYLGIKLSEEMLSSQECTDLCRHVSSVDRLLNDVQTFKKERLENTINSVGLQLAAHKGERAMTEEDAMSKIKEMADYHRRKLMQIVYKEGTVFPRECKDVFLRVCRIGYYLYSSGDEFTSPQQMKEDMKSLVYQPVKIHPLEAINV
Protein: General L-amino acid-binding periplasmic protein AapJ (Q52812)
Organism: Rhizobium johnstonii (strain DSM 114642 / LMG 32736 / 3841) (Rhizobium leguminosarum bv. viciae)
Function: Part of the ABC transporter complex AapJQMP involved in uptake of L-amino acids. Affects the efflux of these amino acids as well. Essential for the development of bacteroids, the differentiated legume-symbiotic forms of this bacterium, and for the effective N(2) fixation by them.
Subcellular location: Periplasm.
Interaction partners:
Sequence:
MKNKLLSAAIGAAVLAVGASAASATTLSDVKAKGFVQCGVNTGLTGFAAPDASGNWAGFDVDFCKAVASAVFGDPTKVKYTPTNAKERFTALQSGEIDVLSRNTTWTINRDTALGFNFRPVTYYDGQGFMVRKGLNVKSALELSGAAICVQSGTTTELNLADYFKTNNLQYNPVVFENLPEVNAAYDAGRCDVYTTDQSGLYSLRLTLKNPDEHIILPEIISKEPLGPAVRQGDDQWFDIVSWTAYALINAEEFGITQANVDEMKNSPNPDIKRFLGSETDTKIGTDLGLTNDWAANVIKGVGNYGEIFERNIGQGSPLKIARGLNALWNKGGIQYAPPVR
Protein: Maternal effect embryo arrest 22 (F4IIV5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Synaptonemal complex protein 2
- Pentatricopeptide repeat-containing protein At1g62590
- Gb|AAF56406.1
- Large ribosomal subunit protein eL19x
- At3g18035
- Diacylglycerol kinase 4
- Putative disease resistance protein At3g14460
- Putative recombination initiation defects 3
- Embryo defective 2737
- Meiosis-specific protein ASY3
Sequence:
MATTNAPPELASGNPCCLAWQGKYIGMKKRRDAFKEGVTLLQKAIENVNAEKSNLERKFGEMATDGDTKENGSTVKASLEKEISRLKFEIVSLQQKLERNLKEKSEETKLLQDQASGREKEINELRDLLKKETLRADSSEEEREHAFKELNKAKALIVKDEEIEQDIPEVKREISLVKNLLASERQKTESERKKAESEKKKADKYLSELEVLRNSAHKTSSDLLTLTSNLETVKKQLELEKQKTLKEKKRADMESAKARDQMKLAEDVSKKFEIVRARNEELKKEMESQTASSQVKFAENSEKLEEKIRLLEMNKKTAMDWKSRTDDLTQQLQEAQLVAEGLKKQVHELSLSQKSIKTHSISPQKVRDLEKAEMRLLKKKMKFERNCAKHSQTVAKFEKFRREFQCEELGRLKLEFGSLTNRMNLLDEYFSTDVEGTAGLGKATGCRKLLTLNSQKNRNGEKHSDARCKLVASSGYQEQACKLSAHLISKSGRGVSESVSGTISQLESPTGGSRKLPSSGVISSATSFSDGQLLASQGREQFSVTTSAEIAKDKPNIQPTKSSMLQKISDTSKNGNLCLVAENYLQRCQRDIHENSRKRKRMLEAVVSHKHLASGDKKKNLPIGEKMGTLQSMIVGTGSRPSEKEETLVPPDRQGGSSAIDITVSKKRRVSCKKKIIVQNSLEFNQSGKTPGNIAGKTTCLSTATGHDVKTLFSEDFAATDYMKLLELDNLEEENYYQMARESLLSPDLPQVDFLGCEIMNEDKNPARAIDLAASNSMYLRETILSSESPSLNTQNISVTVEMPPMLKPLHGHLLKHFIVFSNIEDQNSIIIIIHATNNCLQRCPSVTKEQWAVPAILSSLKMEENLLAQERACVFLSLLLHNFSMVHTTKTGNTLNVDSFSCLDSFSKHIRGVMADTEAGVMLSGFSEELLCLLQDLLSGQRVLFSVKSSETCESDLSIPVTLNGENVALVNKIALTDQLVAGSAILAAICTALDRIGYICEASFEILHKYSHEKTSVLLTILHVFAYIAGEKMVLSSEHGISIAVLKYIVMFLENKHFGTVEGSSRLHPGKNKCPFSDRSSSLEAMASKLMEILQEFTESNTLHKSLTGSLGSSHLEKTEFRPAHKDFQCVLTRDQSINLCDILSLVELIACYTAWDWTSANIVAPLLKMLGMPLPMNLSVAIVSLLGQLSSIGVDAGGYENEGISNLRVKLSAFLQCETTLKAGFAVQIATVSSLLKTLQLKFPIDFQDKTTMIPGSGDQSLSGSVNVVTKWLSLLSKEQRVFAFEFLQTNVVR
Protein: Intron-encoded DNA endonuclease aI4 (DNA endonuclease I-SceII) [Cleaved into: Truncated non-functional cytochrome oxidase 1; DNA endonuclease aI4 (EC 3.1.-.-) (Intron-encoded endonuclease I-SceII)] (P03878)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break at the junction of the two exons a4-a5 of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-TTTGGTCACCCTGAAGTA-3'. The protein may acquire mRNA maturase activity, like the closely related bI4, through a single amino acid substitution Glu-362 to Lys or when present together with a mutant form of the imported mitochondrial leucyl-tRNA synthetase NAM2.
Subcellular location: Mitochondrion.
Interaction partners:
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 3
- Cytochrome b
- ATP synthase subunit a
- Cytochrome b mRNA maturase bI2
- Intron-encoded RNA maturase bI4
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Intron-encoded endonuclease I-SceI
- Intron-encoded DNA endonuclease aI3
- Cytochrome c oxidase subunit 4, mitochondrial
Sequence:
MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGQTVATIIMLMMYNDMHFSKCWKLLKKWITNIMSTLFKALFVKMFMSYNNQQDKMMNNTMLKKDNIKRSSETTRKMLNNSMNKKFNQWLAGLIDGDGYFGIVSKKYVSLEITVALEDEMALKEIQNKFGGSIKLRSGVKAIRYRLTNKTGMIKLINAVNGNIRNTKRLVQFNKVCILLGIDFIYPIKLTKDNSWFVGFFDADGTINYSFKNNHPQLTISVTNKYLQDVQEYKNILGGNIYFDKSQNGYYKWSIQSKDMVLNFINDYIKMNPSRTTKMNKLYLSKEFYNLKELKAYNKSSDSMQYKAWLNFENKWKNK
Protein: Formate dehydrogenase, beta subunit, putative (Q728X1)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Subcellular location: Cell envelope {ECO:0000256|ARBA:ARBA00004196}.
Interaction partners:
- Formate dehydrogenase, alpha subunit, selenocysteine-containing
- Formate dehydrogenase, alpha subunit, selenocysteine-containing
- Formate dehydrogenase 2 subunit alpha
- Iron-sulfur protein CooF
- Pyridine nucleotide-disulfide oxidoreductase
- Carbon monoxide dehydrogenase
- Formate dehydrogenase, beta subunit, putative
- Formate dehydrogenase 2 subunit beta
- Formamidase
- Formyltetrahydrofolate deformylase
Sequence:
MRPLGSLPQGMRRVSRRHIREAYMNGKTFFIDQTRCTACRGCQAACKQWKKFGSIETRNTGSYQNPPDLGPSTFKLVRFNEVEVDGKLKWLFFPEQCRHCLEPPCKMVADALIPGAIVQDAETGAVLYTEKTKGLDYMEVRSACPYDIPRQDPATGLLTKCNMCIDRVQNGMLPACVKTCPTGTMHFGDRADMLELAQKRLGEVKKRSPAALLADSDLVRVLYLCELAPANYHSHMVAEADTSRIGPFSRRALLRLRPFA
Protein: Nucleolar pre-ribosomal-associated protein (F4IBR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At4g31270
- rRNA biogenesis protein RRP5
- DEAD-box ATP-dependent RNA helicase 13
- DEAD-box ATP-dependent RNA helicase 1
- Uncharacterized protein At3g06530
- Periodic tryptophan protein 2
- Starch synthase 3, chloroplastic/amyloplastic
- Protein SLOW WALKER 2
- Putative WD-repeat membrane protein
- DNA-directed RNA polymerase I subunit 2
Sequence:
MAFRPSLEAKLRQLLHNICLHEFKLCSDTAKDFVKLLKGETGSDLLRLYFQSSPNFTELLEAWNLHHGKQGLSYIFSLIQTILSHPEGKSSDIGRALDQFCRLLIEKKLLDIYKALSNTKRLQNAALSLLASIVRRGPGMASEMARTFDFHGFPKQAPRRAFVEFAISFLQVGKPSLLKSILEKKQLYSQLLQGLEEDDDDTLASVLSTLKDKILVQESSLSPRLMSALFGPKTLEQLVIISEREDGGIVNELAYDVLVKVCTDPSNGLMPDAYRKGNIKRLLALMKSLKATETGYPRDLLLAIIRGRPSLASAFFDEFPYNVEDFTSPYWFSSISLAADLVSSVRMSSSFDFLNPDKPPSGGSEVHTIMKCICPRPFSQSLIARGMHHSVFLVKHGTLRFLWETLRLWDSFVTAWKLCSVDQIQASLERDIIGEVISFFPDFQVLWTVLKVSQKLSLKRKAELDIGLVDRKKRLKTSEMAVLEELASDMVIGGLGSDTNIFLEEDTGDAQLTDQEDAENEYLGIVSEIWGSEFCSKPIASVDEAEMFFQIKLLDTLGIYVRSVPNVPKGLFDVFMKFLSSSSITAVGNTLFQQCAIVRSSLSHLKGVSIGFSPLIVCILQKCVKLLNSESQAYSLPNKSAVSLYVYSSLKYILQTQVDPRPLSCLVQSVLSEVVDGSKDSLCEWLPLRVLLLFTQSLSEPFILHSGRTTCRLADTSFAATLDEIKGLMRSITPDEVGGVVNAFSSALICATPESILKNFASVMAVSWDLYGTSFSFLLSIIFLEKNFLGNLSKLSPDLFMRGLELTVSRNLREGTVDSEIDFADHSSTTEKIKSKMDIPDIESLAFSVFLEQTPFPVLLNEIMSMDISCLPEFPRLTELLLLKVSQPKSDSIESDIRLILFWLFQIRSLYKVQPHPVLCQQSEICLRLMRHLFSQISKLDLVSGPSADKLKHQVPQTVLSHPVVMALLESPADCDTLPRVQNVEVFSETLLTAGRLGISEIDQHILDLLASTCENFLFEESHIERKGDLRADKSIMAFKVLVERLLLVFRDKFELCVGSQSYAPLLQHPQLIQALLKFISPFKLLYLAHSMLSKTYEEELASPILSFGLDIAGGAFEMLILYSRQPAAKRRVYDFLWELEDKNYDSRIIEQVYSLACRFSTSFGLASADTCLLKVVSGIFRGGNSQHCSVHQLTVIMSQIVGRTSKDLIIHCINQASMSRAKILFYLVESSPLHLSVFGHIFFSMLSKLQGDSALITDDQFVMLLPPVLLFLASVFAKLEKSCSKCLDITSLYSNILIKGFLQWPKFCSGCIFEEKYEEILLSTSEDIETMFNASLLGKAVRMFQYHFALTESPTKTDDLLKVFYSMFPHTSAGKEMLDYEIKEVDVKSVDQMFNITNRLVAKVELSRICLFPEDSCMHHLKRQAGGCVKESSPEMGSNRESLLNPLLNAFVNTWQCVVERSDGYYKGNSEREEQDKYWFLCKSLEYFILRSILKFLEGMCEELAHLDSLPFLERLMNLILRYRFKDSKTLKILREIFSFLSRGKYSYHFQDLVSHSQFTESISSLSISSSHTGEVIRPVSSILKLLIIPNLNSVRVENCSLEAPEYYLSQIEILKILGVLLCKCGKDSGIFLKDLHFRLLCSYGATPSEIDLQSYKLMHDIKLIVGEHTLNDSEDYLWGNAALKIREGLPSDGSYSDIVEDLRQSLFKENLCLDPKRCAQTVLYFPYGRTAEASDNTYIYDDPISEKCSPAIERYDPVFILRVSVQLLSMVYIEPVEFASLGLLAVAFASMSSADLGIRKLGYETLGIFVDVLESCRKNMHVTVLRLLLTYVQNGVEEQWQRIPTVSAVFSAEASLILLDSSHEHYVPIIKLLKRSSTLKLRGIPLFHDFFGSSTVNFRSQRLWVLRLVFVGLESEEDAQIYIRNSILETVMGFFSSPLADDETKGLILQVVRKSVKLHKMARHLVENCGLLSWCSSFFSMLTTKPTGDEDSRFVVVLEVITDALASRNDTEWSQRSALEGLMEISSRLYTLLGDGLVSMQENGTSILSATLKISHKRKKNQPHFTITIEGIFQLFEAAANCDSPQVEASAEGRLDTILMSTPPVEIICMDVHRLRRFLLWGSSTALKSDLKKGSKPGECHQDTKTHTEETMVAKFLRWLLASVILGKLYSEANDSDQIVLSETKPETLPTLLEYLKKRNLQGSVTNSEHIIGEVIVYLQKHLLCRNYGVLLPSVVFALSLMVLRNGLETTGTESEGGYKVIRSLCSRISSPTEAIPVWRWSYHQDLPSERATDPKEIDELYACQELLLIFSDMLRETPRESQQTLLLGESFDMSSVFEWERVSSLSFPLLRFLPLLPQSSISLTVLPTILSFTDSGDDSLEECVNGCEADDNGEQARA
Protein: Arogenate dehydratase 5, chloroplastic (AtADT5) (EC 4.2.1.91) (Q9FNJ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:19136569}.
Interaction partners:
- Arogenate dehydrogenase 1, chloroplastic
- Chorismate mutase 3, chloroplastic
- Chorismate mutase 1, chloroplastic
- Chorismate mutase 2
- Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
- Histidinol-phosphate aminotransferase 1, chloroplastic
- Arogenate dehydrogenase 2, chloroplastic
- Tyrosine transaminase family protein
- Probable aminotransferase TAT2
- Probable aminotransferase TAT1
Sequence:
MQTISPAFSCDLKSVIQPNLTAKKARYSHVNGKRVSVRCSYRSESFSFPNGVGSSRADWQSSCAILASKVVSAENSSSVAVVNGHSNGSVDLSLVPSKSQHNGKPGLIQPLTITDLSPAPSHGSTLRVAYQGVPGAYSEAAAGKAYPNSEAIPCDQFDVAFQAVELWIADRAVLPVENSLGGSIHRNYDLLLRHRLHIVGEVQIPVHHCLLALPGVRTDCITRVISHPQALAQTEGSLNKLTPKAAIEAFHDTAAAAEYIAANNLHDTAAVASARAAELYGLQILADGIQDDAGNVTRFLMLARDPIIPRTDRPFKTSIVFAAQEHKGTSVLFKVLSAFAFRNISLTKIESRPHQNCPVRVVGDENVGTSKHFEYTFYVDFEASMAEARAQNALAEVQEYTSFLRVLGSYPMDMTPWSTLPSEDV
Protein: Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4) (Q14679)
Organism: Homo sapiens (Human)
Function: Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q80UG8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80UG8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80UG8}. Note=Located in cilia. In some cells, also found in basal bodies. {ECO:0000250|UniProtKB:Q80UG8}.
Interaction partners:
- Cytosolic carboxypeptidase 6
- Cytosolic carboxypeptidase 1
- Tubulin--tyrosine ligase-like protein 12
Sequence:
MASAGTQHYSIGLRQKNSFKQSGPSGTVPATPPEKPSEGRVWPQAHQQVKPIWKLEKKQVETLSAGLGPGLLGVPPQPAYFFCPSTLCSSGTTAVIAGHSSSCYLHSLPDLFNSTLLYRRSSYRQKPYQQLESFCLRSSPSEKSPFSLPQKSLPVSLTANKATSSMVFSMAQPMASSSTEPYLCLAAAGENPSGKSLASAISGKIPSPLSSSYKPMLNNNSFMWPNSTPVPLLQTTQGLKPVSPPKIQPVSWHHSGGTGDCAPQPVDHKVPKSIGTVPADASAHIALSTASSHDTSTTSVASSWYNRNNLAMRAEPLSCALDDSSDSQDPTKEIRFTEAVRKLTARGFEKMPRQGCQLEQSSFLNPSFQWNVLNRSRRWKPPAVNQQFPQEDAGSVRRVLPGASDTLGLDNTVFCTKRISIHLLASHASGLNHNPACESVIDSSAFGEGKAPGPPFPQTLGIANVATRLSSIQLGQSEKERPEEARELDSSDRDISSATDLQPDQAETEDTEEELVDGLEDCCSRDENEEEEGDSECSSLSAVSPSESVAMISRSCMEILTKPLSNHEKVVRPALIYSLFPNVPPTIYFGTRDERVEKLPWEQRKLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPSFRSIREHQKLNHFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFPQSFILPQDAKLLRKAWESSSRQKWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKSLGNKFMHLTNYSVNKKNAEYQANADEMACQGHKWALKALWNYLSQKGVNSDAIWEKIKDVVVKTIISSEPYVTSLLKMYVRRPYSCHELFGFDIMLDENLKPWVLEVNISPSLHSSSPLDISIKGQMIRDLLNLAGFVLPNAEDIISSPSSCSSSTTSLPTSPGDKCRMAPEHVTAQKMKKAYYLTQKIPDQDFYASVLDVLTPDDVRILVEMEDEFSRRGQFERIFPSHISSRYLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLRSWCYKGFHMGVVSDSAPVWSLPTSLLTISKDDVILNAFSKSETSKLGKQSSCEVSLLLSEDGTTPKSKKTQAGLSPYPQKPSSSKDSEDTSKEPSLSTQTLPVIKCSGQTSRLSASSTFQSISDSLLAVSP
Protein: Protein Rv3402c (P9WGJ7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Salicylate synthase
- Uncharacterized MFS-type transporter Rv2456c
- Salicyl-AMP ligase / salicyl-S-ArCP synthetase
- Lysine N-acyltransferase MbtK
- Phenyloxazoline synthase MbtB
- Mycobactin import ATP-binding/permease protein IrtB
- Mycobactin import ATP-binding/permease protein IrtA
- Acetyl hydrolase MbtJ
- Peptide synthetase MbtE
- Peptide synthetase MbtF
Sequence:
MKIRTLSGSVLEPPSAVRATPGTSMLKLEPGGSTIPKIPFIRPSFPGPAELAEDFVQIAQANWYTNFGPNERRFARALRDYLGPHLHVATLANGTLALLAALHVSFGAGTRDRYLLMPSFTFVGVAQAALWTGYRPWFIDIDANTWQPCVHSARAVIERFRDRIAGILLANVFGVGNPQISVWEELAAEWELPIVLDSAAGFGSTYADGERLGGRGACEIFSFHATKPFAVGEGGALVSRDPRLVEHAYKFQNFGLVQTRESIQLGMNGKLSEISAAIGLRQLVGLDRRLASRRKVLECYRTGMADAGVRFQDNANVASLCFASACCTSADHKAAVLGSLRRHAIEARDYYNPPQHRHPYFVTNAELVESTDLAVTADICSRIVSLPVHDHMAPDDVARVVAAVQEAEVRGE
Protein: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 7.1.1.2) (NADH dehydrogenase subunit II) (NADH-ubiquinone oxidoreductase 24 kDa subunit) (P04394)
Organism: Bos taurus (Bovine)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:10852722, ECO:0000269|PubMed:18721790, ECO:0000269|PubMed:25209663}; Peripheral membrane protein {ECO:0000305|PubMed:25209663}; Matrix side {ECO:0000305|PubMed:25209663}.
Interaction partners:
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 3
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
Sequence:
MFLSAALRARAAGLAAHWGKHIRNLHKTAVQNGAGGALFVHRDTPENNPETPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEILQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKGPGFGVQAGL
Protein: Cytochrome c2 (P86318)
Organism: Rhodopseudomonas palustris
Function: Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway. However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.
Subcellular location: Periplasm {ECO:0000269|PubMed:20697695}.
Interaction partners:
- Cytochrome b
- Ubiquinol-cytochrome c reductase iron-sulfur subunit
- Ubiquinol-cytochrome c reductase iron-sulfur subunit
- Cytochrome c oxidase subunit 1
- Reaction center protein L chain
- NADH-quinone oxidoreductase subunit C/D
- Cytochrome c oxidase subunit 3
- Cytochrome C oxidase
- Succinate dehydrogenase cytochrome b556 subunit
- Methionine synthase
Sequence:
QDAAKGEALFKQCQTCHRADKNMVGPALAGVVGRKAGTAPGFSYSPLNHAAGEAGLVWSQENVVEYLADPNAFLKKFLTDKGQADKATGSTKMTFKLANEQQRKDVAAYLATLK
Protein: PRELI domain containing protein 3B (Protein slowmo homolog 2) (Q9CYY7)
Organism: Mus musculus (Mouse)
Interaction partners:
- TP53-regulated inhibitor of apoptosis 1
Sequence:
MKIWTSEHVFDHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHVDPSGKLHSHRLLSTEWGLPSIVKSLIGAARTKTYVQEHSVVDPVTRTMELKSTNISFTNMVSVDERLTYKPHLQDPEKTVLTQEALITVKGVSLSSYLEGLMASTISSNASKGREAMEWVIHKLNAEIEELAASARGSIRTPMAAAAALVDK
Protein: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) (CDPMEK) (CMEK) (Protein PIGMENT DEFECTIVE 277) (O81014)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Is essential for chloroplast development.
Subcellular location: Plastid, chloroplast stroma {ECO:0000305|PubMed:18236010}.
Interaction partners:
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic
- 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
- 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- Mevalonate kinase
- Hydroxymethylglutaryl-CoA synthase
- Phosphomevalonate kinase, peroxisomal
- 1-deoxy-D-xylulose-5-phosphate synthase
Sequence:
MATASPPFISTLSFTHSSFKTSSSSSFSPKLLRPLLSFSVKASRKQVEIVFDPDERLNKIGDDVDKEAPLSRLKLFSPCKINVFLRITGKREDGFHDLASLFHVISLGDTIKFSLSPSKSKDRLSTNVQGVPVDGRNLIIKALNLYRKKTGSNRFFWIHLDKKVPTGAGLGGGSSNAATALWAANELNGGLVTENELQDWSSEIGSDIPFFFSHGAAYCTGRGEIVQDLPPPFPLDLPMVLIKPREACSTAEVYKRLRLDQTSNINPLTLLENVTSNGVSQSICVNDLEPPAFSVLPSLKRLKQRIIASGRGEYDAVFMSGSGSTIIGIGSPDPPQFIYDDEEYKNVFLSEANFMTREANEWYKEPASANATTSSAESRMDFQ
Protein: Death resistor Adh domain containing target, isoform C (EC 1.1.1.-, EC 1.1.1.2) (GH18014p) (Q961L4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPVDICSQPHNLLSSMSGTTDTSLSLNSLSLTSVLPPTDPDHHNPHSTHSTHNMNKLCRQVSIESPGPGAKNCVFNFFVPIEDTPALGARIRIVCAGACYRRRDRANSITSMSSVSSELSDYCPSVNSMSSPAHQGIREGSFFPGFEVAGVIESLGSEITEANNRGLRIGQRVIVYPFDETPAGYAELLVVPDLKHVVPIPDSLPMEVAAMLPTGALLAWNAVFKAQAVVTQILSQRAATEPKRKPKILIVGTGGLALWAVRIASYHFATTGADNVDITVASLRDEGFRLATEIKNVSVVQWNECLYEPQLIERTKDVCGGAVDVVIDFGTTSRSLHRSMHCLSKGGVVLISDEVAEKLLPKFSRLSEQYQQEIIAISNGTAEQLAELVELVANKKIEPPPHSVFPCEQAAEVIAKLCNSEIPGRAILRFHDIE