wanglab/gogpt-training-data huggingface dataset:
Protein: EGF-like domain-containing protein (Q86AS3)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MKLIINNFLLLFLIFLSISIQFVKSINPPQDEFDCLINIINKFNYKTFDSYKDITKICSLTTWVTCDSTTGSVKSFILSNLQYNNYEQAISSDFSCLPNIETLAIYYQNVSKELIYFKSPKLTKLTFFNTQVLGGAALDQPFEKFDDLSITNCKGLDINTPFKFSYFNKVTRFMMSGLYAQLEFDSLAFKNKTSFHLSGSNYPDLTGYTGIQQAEFEFDDTFKLDSISNFAKYTSFGRLIVYHYSNIKIPFYFSQNTKIYSLWLATGGSTFTSPYETPTTMIDLSSTRYTDFLIGGFTNENLNGKFPFIMPSTCSNLNFNSNNLTILPNDIVCKTVSFQNNGINSELPKFIGKADSYDLKNNKFTGTIDQSWCSTELVINNNKLIGKIPSCYSCYLNAPKPSGGLIAMYDRFTGGNSFTNLNKTAVTCTTFAPQVKWLSSNSISVTGIDIGFDPNIWLFNGGVKVMQSINSSPGQYPQLILYSPTLTGETFTINFQYPINYVFTFPKVSKNPLVTSASINGKLYTFNGTYFSSHMRHQYQDIRVKGSLCTIVSTDFYSVTCSANLVIDSALKMVNITTGQDYNKKTTIYIRIDGLVSNDHRCPNDCSGNQGICDLSTGTCYCESGYSGSDCSFKNCGSSVPDCNGAGTCNGATGLCTCDSTHVGDYCQYSTSACPNNCGGSAYGTCNANKTCTCNAGFAGVDCSKPTQCVNNCSGNGVCVNGFCQCFDGYGDSSCSAKILNCPVGAGGAPCNGFYGACNPATGVCTCRDGYQGSACDDRLIQCPVAMNSIVCNRLDINWCDTTTGKCQCDPNFQGVDCSLPLVQCPLYGGKVCGGFGTCNNQTGVCSCDGSHQGADCSLPFIQCPLNGGKVCGGFGTCNNQTGVCTCDGSHQGTSCSLPFVQCPISFLNPCGGSKRGNCNNQIGVCNCLAGYQGLDCSLPFIKCPTINSNDCSGFGSCNNQTGICACDSSHQSTDCSLPFIQCPLNGGKVCSSFGTCDNQIGICTCDGSHQGNDCSKTFVQCPSVNSNSCSGFGSCNNETGACSCNSGRLNNDCSGIQCDVPNCNSHGTCNNTIGKCQCDSSHQGSDCSTPFIDCPSINLNDCSGFGSCNNQTGTCTCNSGKTLSDCTGIQCSVPDCNGHGTCDTNIGKCQCDSSHQGADCSLPLVQCPLYGGKVCGNFGTCNNQTGVCSCDSSHQGSDCSSPFVKCPTVNSNDCSDFGSCNNQTGSCSCDSSHQGADCSLPFIQCPIYSNSLCGGSSFGSCNNQTGVCTCDGSQQGADCSLPLIQCPSINSKDCSGFGSCNNETGICSCNLGRLNNDCSGIQCGSPNCNGHGTCDTTLGVCKCDSSHQGNDCSLPFIKCPSINSNDCSGFGSCNNQTGVCSCNSGRALSDCSGIECSVPNCNNGGVCDTSIGKCQCDSSHQGNDCNIPLIQCPNLCSGFGSCNNQTGICSCNSGRLNNDCSGIQCDVPNCNSHGTCDITIGKCQCLKNTWSGSDCSIPYQVIRSVNESTTAGGEATFEGVFGDVHQGIKMQIGGIDCPIIFNSSTIIKCMAPEGNGIKKVTLFQNDIYYTYDKYKYKAIELSCPSNCLGNGICNTSTGECKCNSGYGSYDCSPIINNGGGGGLGETPNSNSNSGELVIPPKSNTTLNEETGGTNIVNQKTNFQIYFKSLYEIDYSGQIVKTYKLENNWVINNDSNNNDQCTFTQTIDNGCNITSRIDEINDENGKKFEFAGTSFTVSNGGIKFTITIDNYQYQSNLNTLTLDFVSSVGEIQDTQNNNECNSKDTEIDTSNVNDLSSSNFNYIKISKNNKILSGRFINRLLSNGKATFFTTSVRNESNSIIVSLNLPHCSQCIIDPDFSVLLSSDFVSNCPSVVDKRKSYIVPVSVVASVVGAVSVASAGFLIRKKMIERKFFKTYSN
Protein: Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) (P46459)
Organism: Homo sapiens (Human)
Function: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Alpha-soluble NSF attachment protein
- Gamma-soluble NSF attachment protein
- Synaptosomal-associated protein 25
- Beta-soluble NSF attachment protein
- Sec1 family domain-containing protein 1
- Synaptobrevin homolog YKT6
- Glutamate receptor 2
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Gamma-aminobutyric acid receptor subunit alpha-1
- Gamma-aminobutyric acid receptor subunit beta-1
Sequence:
MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFD
Protein: Endonuclease CUE2 (Coupling of ubiquitin conjugation to ER degradation protein 2) (P36075)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Polyubiquitin
- Ubiquitin-ribosomal protein eL40A fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- RQC trigger complex subunit RQT4
- RQC trigger complex helicase SLH1
- Elongation factor 1 alpha-like protein
- Protein DOM34
- 5'-3' exoribonuclease 1
- RQC trigger complex subunit CUE3
- E3 ubiquitin-protein ligase HEL2
Sequence:
MSMDNNDDHESKLSILMDMFPAISKSKLQVHLLENNNDLDLTIGLLLKENDDKSTVDNELHQLYDMFPQLDCSVIKDQFVINEKSVESTISDLLNYETLQKLKDNQANSPDSVKRNEKKNNWESTNDHIESIIKFTDAPKNIAQEYLAENGFDTVKAIIKIILDYYDKRDFKKDVDTFKVKRSPNTTVRGGRVQSSTGLAHVLKKGKESANVAQESLKRPRSYKHSLDSPQMVELNELVADNRDLKAINHEFLQKCLQFYDGDVVKVLNISSLLIEDDKNITKTWNFDEGFTLTSRDNCKQHLPKFSTPQISRRNEVGNTYKLPLHDKETPEGAVPVINNLFQTYRLDFHGFLPSEAVSTLKLALNKWWSKEVAERELNSHNINSYGSKVQFVSPLIVVTGRGIHSIGGISKVRLQVKSFLEKNHYIFWEESSYFRIEGKKKK
Protein: F-box/LRR-repeat protein At3g58930 (Q8GXW6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDRVSNLPDGVRGHILSFLPAKHIALTSVLSKSWLNLWKLIPILDIDDSEFLHPEEGKAERLEIRQSFVDFVDRVLALQDDSPIDRFSLKCITGIHPDHVNRWICNVLQRGVSDLDLFIDFSYEDTQEDEDMLPQEMFVSKTLVKLKIRNDRCVDWWCGKGGTSLPMLKSLYIDSDLILWGKMKRFLSSFPVLEELRMASMEWKESHETVSSASLRKLSILGTGCEDYVNPKSISFDTPSLLYLNYSDLVAEDYPLVNMGKLLEARINLIVKDDQIKRVREPNNDLLQDDAGNVVLQFGNVVKLMNGIQNIQILYLTADTLEVLSLCCESMPVFNNLKTLGIKSEEGRGWQAVPALLRNCPHLEYLIIEGLLHNVTDKCGDACDCISREDKGRSLASCPVKKVEIQGFRGTMREINMIGHFLRSFKCLKEMGIFPEEEGPTNFENPGAFEYVEKILKLYNEISNCDVYFLVWGYMRRKWTTQ
Protein: Probable terpene synthase 3, chloroplastic (EC 4.2.3.-) (Q29VN1)
Organism: Zea mays (Maize)
Function: Probable terpene synthase.
Subcellular location: Plastid, chloroplast {ECO:0000250|UniProtKB:Q29VN2}.
Interaction partners:
Sequence:
MYSLPGATMSAAPARVISSSSSSSFVEPLLLAAASSAAANSHHQVRQRGHLVRTLAASSSSNTLLRSDFDLQEGLTTDVKRMLRQRQKKSGGGREMLVTIDNLKRLCIDHFFEEEIEGAMATGACTRLLHSDDLFDATLAFRLLREAGHDVSAKEDVLRRFIDGVSGDFKLSLNNDVRGLLGLHDMSHLDVGGEEAALLHRAKEFSSSHLASAVRYQDNPSLAEYVRQSLDHPYHLSLTQYKARHHLRYLQSLPSSCRDAAVERLAVAEFQLNKSLHQREMREIKRWWMDLGLAEEIPVVRDQVMKWYMWSMAALQGSSFSRYRVYVVDDIFDLVGTLEELSAFTEAVKMWDTAAADSLPSCMRSCYKALHTVTNEIAEIAHKEHGSNPINRLRKAWVVLFDGFMVEARWLATDQVPTAEDYLRNGVVTSGVPLTFLHIFSMLGYDDPSTEEEEEAIIDHMPSIISCPAKILRLWDDMGSAEDEAQEGFDGSYRDFYLMENPSRSPGEAEAHMRGLIAREWVELNRECFCRRTFPSDIAQVCLNTARMVSVMYSYNKEQRLLVLEDYAAMMLVL
Protein: 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase (EC 4.1.1.117) (Staphyloferrin B biosynthesis protein SbnH) (Q2G1M6)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Catalyzes the decarboxylation of citryl-L-2,3-diaminopropionic acid to citryl-diaminoethane, the second step in staphyloferrin B biosynthesis.
Interaction partners:
- L-2,3-diaminopropanoate--citrate ligase
- 2-[
- Staphyloferrin B synthase
- N-
- ATP-dependent L-serine kinase SbnI
- Staphyloferrin B transporter
- N-
- HpcH/HpaI aldolase/citrate lyase domain-containing protein
- Histidine biosynthesis bifunctional protein HisIE
Sequence:
MRIVQPVIEQLKAQSHPVCHYIYDLVGLEHHLQHITSSLPSNCQMYYAMKANSERKILDTISQYVEGFEVASQGEIAKGLAFKPANHIIFGGPGKTDEELRYAVSEGVQRIHVESMHELQRLNAILEDEDKTQHILLRVNLAGPFPNATLHMAGRPTQFGISEDEVDDVIEAALAMPKIHLDGFHFHSISNNLDSNLHVDVVKLYFKKAKAWSEKHRFPLKHINLGGGIGVNYADLTNQFEWDNFVERFKTLIVEQEMEDVTLNFECGRFIVAHIGYYVTEVLDIKKVHGAWYAILRGGTQQFRLPVSWQHNHPFDIYRYKDNPYSFEKVSISRQDTTLVGQLCTPKDVFAREVQIDAISTGDVIVFKYAGAYGWSISHHDFLSHPHPEFIYLTQTKEDE
Protein: Homeobox protein Hox-A5 (Homeobox protein Hox-1.3) (P52949)
Organism: Rattus norvegicus (Rat)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity).
Subcellular location: Nucleus.
Interaction partners:
Sequence:
HNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSGSGHFGSGEXXRSYXAGASAAPAEPRYSQPATSTHSPPPDPLPCSAVAPLPGSDTHHGGKNSLGNSSGCSANCGSTHISSREGVGTASAAEEDAPASSEQAGAQSEPSPAPPAQPQIYPWMRKLHISHDNIGGPEGKRARTCYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDK
Protein: ABC transporter domain-containing protein (C0P274)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVLPFPIPMPHSTIVRWLRRYLQNEKAKRKAKESDIECSSSENESNDSTPLRGDGQLAESSRIPKKKMNRLRQFSLLLWKDWVLLRRNKVWTLFELIIPCLLLGPLVYLVVKNADHTSSPENIYDNFQVKGTVEDVFLESNFIKPIYKRWCLRSDVVVGYTSKDAAAKRTVDDLMKKFAERFQSAKLKLSVKNESSEEQLLTVLRNDLPMLNETFCAINSYAAGVVFDEVDVTNKKLNYRILLGKTPEETWHLTETSYNPYGPSSGRYSRIPSSPPYWTSAFLTFQHAIESSFLSSVQSGAPDLPITLRGLPEPRYKTSSVSAFIDFFPFIWAFVTFINVIHITREIAAENHAVKPYLTAMGLSTFMFYAAHVVMAFLKFFVIFLCSIIPLTFVMEFVSPAALIVTVLMYGLGAVIFGAFVASFFNNTNSAIKAILVAWGAMIGISYKLRPELDQISSCFLYGLNINGAFALAVEAISDYMRRERELNLTNMFNDSSLHFSLGWALVMMIVDILWMSIGALVVDHIRTSADFSLRTLFDFEAPEDDENQTDGVTAQNTRINEQMNPMASTSLNPPNADSDSLLEGSTEADGARDTARADIIVRNLVKIWSTTGERAVDGLSLRAVRGQCSILLGHNGAGKSTTFSSIAGIIRPTNGRITICGYDVGNEPGETRRHIGMCPQYNPLYDQLTVSEHLKLVYGLKGAREKDFKQDMKRLLSDVKLDFKENEKAVNLSGGMKRKLCVCMALIGDSEVVLLDEPTAGMDPGARQDVQKLVEREKANRTILLTTHYMDEAERLGDWVFIMSHGKLVASGTNQYLKQKFGTGYLLTVVLDHNGDKRKMAVILTDVCTHYVKEAERGEMHGQQIEIILPEARKKEFVPLFQALEAIQDRNYRSNVFDNMPNTLKSQLATLEMRSFGLSLNTLEQVFITIGDKVDKAIASRQNSRISHNSRNASEPSLKPAGYDTQSSTKSADSYQKLMDSQARGPEKSGVAKMVAQFISIMRKKFLYSRRNWAQLFTQVLIPIILLGLVGSLTTLKSNNTDQFSVRSLTPSGIEPSKVVWRFENGTIPEEAANFEKILRKSGGFEVLNYNTKNPLPNITKSLIGEMPPATIGMTMNSDNLEALFNMRYYHVLPTLISMINRARLTGTVDAEISSGVFLYSKSTSNSNLLPSQLIDVLLAPMLILIFAMVTSTFVMFLIEERTCQFAHQQFLTGISPITFYSASLIYDGILYSLICLIFLFMFLAFHWMYDHLAIVILFWFLYFFSSVPFIYAVSFLFQSPSKANVLLIIWQVVISGAALLAVFLIFMIFNIDEWLKSILVNIFMFLLPSYAFGSAIITINTYGMILPSEELMNWDHCGKNAWLMGTFGVCSFALFVLLQFKFVRRFLSQVWTVRRSSHNNVQPMMGDLPVCESVSEERERVHRVNSQNSALVIKDLTKTFGRFTAVNELCLAVDQKECFGLLGVNGAGKTTTFNILTGQSFASSGEAMIGGRDVTELISIGYCPQFDALMLDLTGRESLEILAQMHGFENYKAKAELILECVGMIAHADKLVRFYSGGQKRKISVGVALLAPTQMIILDEPTAGIDPKARREVWELLLWCREHSNSALMLTSHSMDECEALCSRIAVLNRGSLIAIGSSQELKSLYGNNYTMTLSLYEPNQRDMVVQLVQTRLPNSVLKTTSTNKTLNLKWQIPKEKEDCWSAKFEMVQALAKDLGVKDFILAQSSLEETFLRLAGLDEDQLDTHSTVEISHSTHV
Protein: TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) (Q9UKE5)
Organism: Homo sapiens (Human)
Function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
Subcellular location: Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Interaction partners:
- SH2/SH3 adapter protein NCK1
- Ras-related protein Rap-2a
- Striatin-4
- Disrupted in schizophrenia 1 protein
- Catenin beta-1
- Misshapen-like kinase 1
- TNF receptor-associated factor 2
- Striatin
Sequence:
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Protein: Possible transcriptional regulatory protein (Probably TetR-family) (O53310)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible dioxygenase
- Amine oxidase domain-containing protein
- Siderophore exporter MmpL5
- HTH-type transcriptional regulator MmpR5
- 2-heptyl-1-hydroxyquinolin-4
- PaaX domain-containing protein, C-domain protein
- Probable transcriptional regulatory protein
- Probable transcriptional regulatory protein
- Putative antitoxin HigA3
Sequence:
MPRQAGRWSPTALRILGAAAELIALRGYSSTSTRDIAAAVGVEQPAIYKHFSAKRDILAALVRLAVEWPLELFGHITAMPVPAVVKLHRWLTESLDHLHASPYVLVSILITPDLHQESFVAERELVAEMERALVGLIETGQGEGDVRAMHPLSAARLVQALFDALALPEFAVSPDEIVEFAMTALLSDPDRLAEIRAAADALEIQTAPPDRGL
Protein: Secreted effector protein PipB (Q8ZQ59)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Does not appear to be required for the formation or the maintenance of either Salmonella-containing vacuole (SCV) or the Salmonella-induced filaments (Sifs). Not required for intracellular replication in phagocytic cells.
Subcellular location: Secreted {ECO:0000269|PubMed:11918798}. Host membrane {ECO:0000269|PubMed:12864852}. Note=Secreted via type III secretion system 2 (SPI-2 T3SS), and delivered into the host cell. Concentrates in detergent-resistant microdomains (DRMs) that are present on the membranes of Salmonella-containing vacuole (SCV) and Salmonella-induced filaments (Sifs). {ECO:0000269|PubMed:11918798}.
Interaction partners:
- Secreted effector protein SifA
- Secreted effector protein SseJ
- Secretion system effector
- Secreted effector protein sopD2
- Inositol phosphate phosphatase SopB
- Secreted effector protein SifB
- Deubiquitinase SseL
- E3 ubiquitin-protein ligase SspH2
- Salmonella pathogenicity island 2 protein C
- Secretion system effector
Sequence:
MPITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERWFREVIGKLTTSLLYVNKNAFFDGNKIFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDKVDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVNLAHKDFQGEDLSKIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSDLTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDRTLFPHPIF
Protein: Origin of replication complex subunit 4 (F4IM82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR007858}.
Interaction partners:
Sequence:
MGKETPAEKSLNLIRGRLCDPSYVFRPLSASSDSNYSKLKFIVSTSITEGCNNSMLLLGPRGSGKAAVLDLXXGXLLEQFPDSVSVIRLNGLLHSDDNCAFKEIAKQLCMEHHLLFSKMASFDDNSQFIIAMLRACGLAHKTIIFVLDEFDMFAQGKQRLLYSXLDDAMQSVTSQAVVVGISSRLDADQLLEKRVRSRFSHRKFLFLPPSREELDGLFVHLLSLPADSGFPSGYVSRFNDKIKNLTSDTRFKDILKTLFNANSTVNSFLKFILSLDVRFCAVSLMNLESGLLSLENFKAALSSMQRQPKLEAVRDCSVLELYLLVCMRRLEVKEQSSYNFISVMKEYKAIHDSFHTSDYYAQNVCLRAFEHLRERQVICYAENRGQSQTGEYRLQKLLISASELHQGMRSHACCPAILLKLLDH
Protein: Probable LRR receptor-like serine/threonine-protein kinase At4g37250 (EC 2.7.11.1) (C0LGS3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- AT5g23340/MKD15_20
- At4g27652
- At1g66080
- At4g27654
- GEM-like protein 6
- FCS-Like Zinc finger 13
- Expressed protein
- Metalloendoproteinase 3-MMP
- Formin-like protein 4
- GSH-induced LITAF domain protein
Sequence:
MRMELISVIFFFFCSVLSSSALNSDGLVLMKFKSSVLVDPLSLLQTWNYKHESPCSWRGISCNNDSKVLTLSLPNSQLLGSIPSDLGSLLTLQSLDLSNNSFNGPLPVSFFNARELRFLDLSSNMISGEIPSAIGDLHNLLTLNLSDNALAGKLPTNLASLRNLTVVSLENNYFSGEIPGGWRVVEFLDLSSNLINGSLPPDFGGYSLQYLNVSFNQISGEIPPEIGVNFPRNVTVDLSFNNLTGPIPDSPVFLNQESNFFSGNPGLCGEPTRNPCLIPSSPSIVSEADVPTSTPAIAAIPNTIGSNPVTDPNSQQTDPNPRTGLRPGVIIGIVVGDIAGIGILAVIFLYIYRCKKNKIVDNNNNDKQRTETDTITLSTFSSSSSSPEESRRFRKWSCLRKDPETTPSEEEDEDDEDEESGYNANQRSGDNKLVTVDGEKEMEIETLLKASAYILGATGSSIMYKAVLEDGRVFAVRRLGENGLSQRRFKDFEPHIRAIGKLVHPNLVRLCGFYWGTDEKLVIYDFVPNGSLVNPRYRKGGGSSSPYHLPWETRLKIAKGIARGLAYLHEKKHVHGNLKPSNILLGHDMEPKIGDFGLERLLTGETSYIRAGGSSRIFSSKRYTTSSREFSSIGPTPSPSPSSVGAMSPYCAPESFRSLKPSPKWDVYGFGVILLELLTGKIVSVEEIVLGNGLTVEDGHRAVRMADVAIRGELDGKQEFLLDCFKLGYSCASPVPQKRPTMKESLAVLERFHPNSSVIKSSSFHYGH
Protein: Non-specific lethal 1, isoform E (Non-specific lethal 1, isoform P) (E1JIM0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAPALTAEPLSPKEKLTSTASPSARSSSESGGVGCAVGLVKKPATPTPATATTRITRSSAAAASVTASPHLQQQRSSLAINNKRKSGNAKASNEPMGLSTAPTPHSTTSPNPSTDTAAASTSAVEHNNNDSNSTSAGNSTSADNSSTPKDNSTAQLLADLTINFEETISAEICLRKTLPDVSLGKEPVPPASVLAVATSSTSAGSALSLSAVDEVTKIEIDNIEERLSQLDGNATGRPEEHVAPPSVPVPVQEAPNTPTRPQAPPSAHLESPQPARTQQQSIQQMTPQSTTSSNNFLKDGAAGAVLEDQDIEEVLKALKTFDGGHVNPDTICEFFDEVWEEAAPAAPLPPAPPENVVDVPGAKPSCSGILVSGSNISQPNVIIKQEQRPWQESHAELEQQQHVISRRIEFLLRRMRKLQARAMCRHASEEVVGIMEWSARSSHKAPVPARSSTLTEQEATVLSIVSGRPSSTFWEEQNKHPLPASQMSNVIRHIATAAKHQQICHSASGSSATLAPSSSWYNSCNSSALPMKRPRKNQLDASVATGATPTAPAPGAVTSRQAAGTTGSATGSNTPRADDIVPGYDTYVTNELTHVSGLLHTELREVQNAIDSDATESSSGGESADEMVTYNNNQQLSLPITRRAVWRYSRDRAAIALRWSWLCSQLTDLEMKIRQHSDLYMDLTQSKGEIQLESTAKTSPSLAQPANGIKEEPGSDYLCSRARPLVLSEFRKRKLFQTTNMHTISKKAARPSNIKCGCQWPQVPCTLCTGRTDPTAPRDLVETMMPQNRVALLDAGYHPVLSFASDVSQSVHLEAVARQPDWQYRVMRSQPKAIVKAMWKAERETIASGGVGGQGGSRRSGDAAKRRYIRRKERNNNSNKEAGSGAKAAAVAAGGAGGNGSSSVGGGDSGNAAARGKRQPQHPTGANSSSSLWPDSRQRQRQRHHSPSSTSISALSGAKKARKSATNSSSSNSTQQQQNHHGTKINNHHLNGYGDQWGEQSRSRRNSSPSNSHKNERTSERRVRPIYDINNIVIPYSMLAQSKMEIIPYKEIPIPKWRIVDSDNDKGKHSSDESMERKLSNGCVASKSEELAKQQLPPPPDQDQEQPALQPPKVNGLKENQAVKHNNNNNTNNNNNKNGLVNGNAKKDELKAAEDHDTQSKEDDDPKEKVVKPKLNGNLIKNPIDKTAETQDKIAQPAPEPPLPKRPKLETPTSNEVTKANGQLVQQQLESRESEEEPQHVDEDLSDEAFIMRHQRALLEERRRFETFLKFPWSTRSRANRRVDSRAESSGANTPDPASPAPHLGGPGHDNESIPSPLAYPLDAFNESGELLTGGQARQARRRTTSSKLKDQLERRSTTPDLRESYTVMPSPFEPLNFPLSDEVYQRLLAETYAPPRSMTVSKRAKSKSISSNCDGGNTFTGGSGSRRSSKCKIKPNGQLNGQLNGHPAAAKLNGIDAANEGGISEPEEEEMLLEDEDDDYPKHHLAPLDDEEPSTPDVEHELYDSAIDAYLADPEALEEDMGEDPFEDDDPNDPEWKTRTEGVRSRRI
Protein: IP21282p (Q59DY1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLCYRECQKILENAQESAVRVKLLDYHLVRDLSAIGYLGDYYALTLRYCHEEEEIIREIELFVKAMPQQSAELSKESIFQKESWLYDTLIKKLQALSNVKWSPNCVYSRKDLMVLENIKLKGFTSAGSAELNEVFVKPLIKSIAAFHSASLVYEHQTKTNIGHTYGDNLLEITVDSEIAWFTTGLSAVLAVVRSLAKYQGNREQSFIGDKLMGIMETIYEQAAPSKKYRNVLCHRDIWAGNIFFPPENSGPALLIDFQTCRYAPPASDLNFCLYMNLSSSKRKQMEKQGIDLYHTYLLQNLSDLGLEELVISKSELLESYEEFRLFGVVYRAVAATVVKVPTDFITNDFKYVDRSKVILSYMKTNPEFATYMEECCVDVMEMALARANM
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A8I5ZV95)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHGQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPLEKKPLYHYKEGMSPSEKPAWAKEIPQLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPVLESSLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPSKVKPEESRDIPRPSRPASYKKAIDEDLTALAKELRELRIEETNRPLKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGKNEQYNMGMVGTHGLETSHADTFGGSISREGTLMIRETAEEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDTGAEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDDESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Protein: Plakophilin-2 (F1M7L9)
Organism: Rattus norvegicus (Rat)
Function: Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (By similarity). Required to maintain gingival epithelial barrier function (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes. Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling. May play a role in junctional plaques (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q99959}. Cell junction, desmosome {ECO:0000269|PubMed:21617128}. Cell junction {ECO:0000269|PubMed:19661460, ECO:0000269|PubMed:26858265}. Cytoplasm {ECO:0000250|UniProtKB:Q99959}. Note=Colocalizes with CTNNA3 and SCN5A/Nav1.5 at intercalated disks in the heart. {ECO:0000269|PubMed:19661460}.
Interaction partners:
- Desmoglein 2
- Desmoplakin
- Desmocollin 2
- Junction plakoglobin
- Desmoglein 1
- Desmoglein 3.
- Desmocollin 3
- Desmocollin 1
Sequence:
MAIPGSLGECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSSGRGDPVARSQRIQEQVQQTLARRGRSSVVGGNLHRTSSVPEYVYKLHLVENDFVGRQSPAARDYDMLKVGLSGWRDGSTLKVPCTSIKPHREKKTWIEALREGLEHTTDHTDCPAHYVYSHYYFNSKKSNILVFQHIKDKSLQRNAIILLSPEHCTCQHVRLIPSSVLPSLFNQLQLSPELYFSNMGTLYMTSIKGTLCIQLLKGKLPAKHQANFVTMAERRVYTLLLSSTTSSETSFRRTGDTLPSVTSGQSRVHGLHFHHVICDCLSRNADLEMTLERAVNMLDADHVPLSKISAAATFIQHESFQKSEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKVTVVLGKVNITKREGGGQAAGYMKETWKLANKNPVFLGLLWNLSSSDKLKHLMITEALLTLTESVIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKVMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRSRKVKEQYQDTPMPEERSSPRGIEWLWHSIVIRMYLSLIAKSSRNYTQEASLGALQNLTAGSGPIPTSVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTISIGEGYAPNKASKAASVLLYSLWAHTELHNAYKKAQFKKTDFVNSRTAKASHSLKD
Protein: Uncharacterized protein C338.12 (O74989)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSQKSYIVQLKDSVDPASMDKIKSDLEASGAKIGHTYDTVFKGFSVSLPENAVDALSAHPEIQHFEPDQEMHTMKKD
Protein: Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) (P48507)
Organism: Homo sapiens (Human)
Interaction partners:
- Glutamate--cysteine ligase catalytic subunit
- Glutathione synthetase
- Nuclear factor erythroid 2-related factor 2
- NAD
- Glutathione hydrolase 1 proenzyme
- 5-oxoprolinase
- Kelch-like ECH-associated protein 1
- Aminopeptidase N
- Gamma-glutamylcyclotransferase
- Glutathione hydrolase 6
Sequence:
MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS