wanglab/gogpt-training-data huggingface dataset:
Protein: Syntaxin-1B (P61264)
Organism: Mus musculus (Mouse)
Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Subcellular location: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Interaction partners:
- Vesicle-associated membrane protein 2
- Syntaxin-binding protein 1
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 1
- Synaptosomal-associated protein 25
- Vesicle-associated membrane protein 4
- Synaptosomal-associated protein 23
- Syntaxin-1A
- Syntaxin-3
- Beta-soluble NSF attachment protein
Sequence:
MKDRTQELRSAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVLASSIGGTLGL
Protein: Protein arginine N-methyltransferase 1 (EC 2.1.1.125) (Q8ILK1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Histone H4
- Small ribosomal subunit protein uS5
- Histone H2A
- rRNA 2'-O-methyltransferase fibrillarin
- Small ribosomal subunit protein eS30
- Multifunctional methyltransferase subunit TRM112, putative
Sequence:
MTNKFNKINKNNYETREAVYYDKGNRINSNKEKEMKEFKEEELKEFFNKWNPFYKEKLNSEIEKKNFINFDGEKKMENGNNEYFNSYNYIHIHEDMIKDEVRTRTYYDSIRKNEHLIKDKIVLDVGCGTGILSFFAATHGAKHVYSIEKSDIIYTAIKIRDENNLTDKVTFLKGLAEEIELPVDKVDIIISEWMGYCLLYENMLDTVLYCRDKWLKEGGLIFPDKAHMYIAGIEDSLYREEKFDFWKNCYDLNFSSVLPIIKEEVVIDYVDRNFVVTDTCCILTLDLNTCTPDQLSFVSPFQLKMIRKDYLHALVIWFDISFSACHTEVNFTTGPYGAHTHWKQIVLYTDHIITAERNETLKGIFALKRNQKNKRHLDMKLHYIFDGVHTKAKSTQLFNIS
Protein: Arsenical-resistance protein ARR1 (AP-1-like transcription factor YAP8) (Arsenic compound resistance protein 1) (Q06596)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription activator required for resistance to arsenic compounds and for a regulated expression of ACR2, ACR3 and YCF1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15147884}. Nucleus {ECO:0000269|PubMed:15147884, ECO:0000269|PubMed:31772124}. Note=Predominantly localized in the cytoplasm under non-stress conditions and redistributed into the nucleus after HOG1 phosphorylation in the presence of arsenic (PubMed:15147884, PubMed:31772124). The major karyopherinse CRM1 mediates nuclear export which is also regulated by arsenic stress (PubMed:15147884). {ECO:0000269|PubMed:15147884, ECO:0000269|PubMed:31772124}.
Interaction partners:
- Arsenical-resistance protein 2
- AP-1-like transcription factor YAP1
- Arsenical-resistance protein 3
- Metal resistance protein YCF1
- Mediator of RNA polymerase II transcription subunit 2
Sequence:
MAKPRGRKGGRKPSLTPPKNKRAAQLRASQNAFRKRKLERLEELEKKEAQLTVTNDQIHILKKENELLHFMLRSLLTERNMPSDERNISKACCEEKPPTCNTLDGSVVLSSTYNSLEIQQCYVFFKQLLSVCVGKNCTVPSPLNSFDRSFYPIGCTNLSNDIPGYSFLNDAMSEIHTFGDFNGELDSTFLEFSGTEIKEPNNFITENTNAIETAAASMVIRQGFHPRQYYTVDAFGGDVLLSAMDIWSFMKVHPKVNTFDLEILGTELKKSATCSNFDILISLKHFIKVFSSKL
Protein: Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (CYPIIB20) (Cytochrome P450 2B20) (Cytochrome P450 clone PF3/46) (Cytochrome P450-16-alpha) (P24) (Testosterone 16-alpha hydroxylase) (P12791)
Organism: Mus musculus (Mouse)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 1A2
- Cytochrome P450 1A1
- Cytochrome P450 7A1
- UDP-glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- Nuclear receptor subfamily 1 group I member 3
Sequence:
MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLLQMDRGGLLKSLIQLREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVAVVEPTFKEYGVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANVICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQMFELFSGFLKYFPGAHRQISKNLQELLDYIGHSVERHKATLDPSVPRDFIDIYLLRMEKEKSNQNAEFHHQNLMMSVLSLFFVGTETSSTTLHYGFLLMLKYPHVTEKVQKEIDQVIGSHRLPTLDDRTKMPYSDAVIHEIQRFSDLIPIGVPHRVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQPDSFNPDQFLDANGALKKSEAFLPFSTGQIFDQKSVGKRICLGESIARSELFLFFTSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR
Protein: Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7) (snGPCR32) (Q8K5E0)
Organism: Rattus norvegicus (Rat)
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Lysophosphatidic acid receptor 6
- Lysophosphatidic acid receptor 4
- Lysophosphatidic acid receptor 5
- Guanine nucleotide-binding protein G
- Lysophosphatidic acid receptor 2
- Lysophosphatidic acid receptor 1
- Angiotensinogen
- Proteinase-activated receptor 1
- Prothrombin
- Muscarinic acetylcholine receptor M1
Sequence:
MNECHYDKRMDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVITNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWLLRQGLLDTSLTASLANLLVIAVERHMSIMRMRIHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVVVYVRIYMYVKRKTNVLSPHTSGSISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKRWFLLLALLNSVMNPIIYSYKDEDMYNTMRKMICCAPHDSNAERHPSRIPSTIHSRSDTGSQYLEDSISQGQVCNKSSS
Protein: Splicing factor 3b, subunit 2 (D3ZMS1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- PHD finger-like domain-containing protein 5A
- Splicing factor 3B subunit 4
- Splicing factor 3B subunit 3
- Splicing factor 3B subunit 5
- Splicing factor 3B subunit 1
- Splicing factor 3A subunit 1
- Splicing factor 3a, subunit 3
- Splicing factor 3A subunit 2
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Pre-mRNA-processing factor 6
Sequence:
MAAEHPEPPKGELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGSREELVERLQTYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLSGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQAAVLMEQERQQEIAKMGTAVPRPPQDMGQLGVRTPLGPRVAAPVGPVVPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDTRSSLGQSASETEEDTVSTSKKEKNRKRRNRKKKKKPQRVRAASSESSGDREKDSARSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKMENSAVPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF
Protein: Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) (Q9QUL6)
Organism: Rattus norvegicus (Rat)
Function: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Alpha-soluble NSF attachment protein
- Beta-soluble NSF attachment protein
- Sec1 family domain-containing protein 1
- Multifunctional fusion protein
- Syntaxin-1A
- Gamma-aminobutyric acid receptor subunit alpha-1
- Glutamate receptor 2
- Gamma-aminobutyric acid receptor subunit alpha-4
- Gamma-aminobutyric acid receptor subunit gamma-2
- Gamma-aminobutyric acid receptor subunit beta-1
Sequence:
MAGRTMQAARCPTDELSLSNCAVVNEKDYQSGQHVMVRTSPNHKYIFTLRTHPSVVPGCIAFSLPQRKWAGLSIGQDIEVALYSFDKAKQCIGTMTIEIDFLQKKNIDSNPYDTDKMAAEFIQQFNHQAFSVGQQLVFSFNDKLFGLLVKDIEAMDPSILKGEPASGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALMREEGASPLDFD
Protein: Phosphoserine aminotransferase 1, chloroplastic (AtPSAT1) (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (Q96255)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the plastidial phosphorylated pathway of serine biosynthesis (PPSB). Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:9881164}.
Interaction partners:
- D-3-phosphoglycerate dehydrogenase 2, chloroplastic
- Phosphoserine phosphatase, chloroplastic
- D-3-phosphoglycerate dehydrogenase 1, chloroplastic
- D-3-phosphoglycerate dehydrogenase 3, chloroplastic
- cysteine synthase
- Cysteine synthase, mitochondrial
- Threonine synthase 1, chloroplastic
- Cysteine synthase, chloroplastic/chromoplastic
- Cysteine synthase 1
- Bifunctional L-3-cyanoalanine synthase/cysteine synthase D1
Sequence:
MAATTNSFLVGSNNTQIPALKPKSSSQSFLHLSKPNTVNFVSKTKPVAVRCVASTTQVQDGVRSGSVGSQERVFNFAAGPATLPENVLLKAQADLYNWRGSGMSVMEMSHRGKEFLSIIQKAESDLRQLLEIPQEYSVLFLQGGATTQFAALPLNLCKSDDTVDFVVTGSWGDKAVKEAKKYCKTNVIWSGKSEKYTKVPSFEELEQTPDAKYLHICANETIHGVEFKDYPVPKNGFLVADMSSNFCSKPVDVSKFGVIYGGAQKNVGPSGVTIVIIRKDLIGNAQDITPVMLDYKIHDENSSLYNTPPCFGIYMCGLVFEDLLEQGGLKEVEKKNQRKADLLYNAIEESNGFFRCPVEKSVRSLMNVPFTLEKSELEAEFIKEAAKEKMVQLKGHRSVGGMRASIYNAMPLAGVEKLVAFMKDFQAKHA
Protein: Methylesterase 3 (AtMES3) (EC 3.1.1.-) (O80477)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methylesterase shown to have carboxylesterase activity, methyl indole-3-acetic acid (MeIAA) esterase activity and methyl jasmonate (MeJA) esterase activity in vitro.
Interaction partners:
- Probable carboxylesterase 12
- Leucine-rich repeat
- AT2G01100 protein
- Prolyl endopeptidase
- Prolyl endopeptidase
- Acylamino-acid-releasing enzyme
- UDP-glycosyltransferase 91B1
- Protein STRICTOSIDINE SYNTHASE-LIKE 7
Sequence:
MSEEERKQHVVLVHGACHGAWCWYKVKPQLEASGHRVTAVDLAASGIDMTRSITDISTCEQYSEPLMQLMTSLPDDEKVVLVGHSLGGLSLAMAMDMFPTKISVSVFVTAMMPDTKHSPSFVWDKLRKETSREEWLDTVFTSEKPDFPSEFWIFGPEFMAKNLYQLSPVQDLELAKMLVRANPLIKKDMAERRSFSEEGYGSVTRIFIVCGKDLVSPEDYQRSMISNFPPKEVMEIKDADHMPMFSKPQQLCALLLEIANKYA
Protein: Peroxisomal membrane protein 2 (22 kDa peroxisomal membrane protein) (Q07066)
Organism: Rattus norvegicus (Rat)
Function: Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
Subcellular location: Peroxisome membrane; Multi-pass membrane protein.
Interaction partners:
- Peroxisomal membrane protein 4
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein PMP34
- ATP-binding cassette sub-family D member 1
- Peroxisomal membrane protein PEX16
- Peroxisomal membrane protein PEX13
- ATP-binding cassette sub-family D member 3
- Peroxisomal biogenesis factor 11 beta
- Outer mitochondrial transmembrane helix translocase
- Peroxisomal membrane protein 11A
Sequence:
MAPAASRLRVESELRSLPKRALAQYLLFLKFYPVVTKAVSSGILSALGNLLAQMIEKKQKKDSRSLEVSGLLRYLVYGLFVTGPLSHYLYLFMEYWVPPEVPWARVKRLLLDRLFFAPTFLLLFFFVMNLLEGKNISVFVAKMRSGFWPALQMNWRMWTPLQFININYVPLQFRVLFANMAALFWYAYLASLGK
Protein: tRNA hydroxylation protein P1 (EC 3.4.-.-) (O32034)
Organism: Bacillus subtilis (strain 168)
Function: Involved in prephenate-dependent formation of 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-methoxyuridine (mo5U) biosynthesis.
Interaction partners:
- tRNA 5-hydroxyuridine methyltransferase
- tRNA hydroxylation protein P2
- Uridine kinase
- UPF0741 protein YwzC
- tRNA uridine
Sequence:
MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADAVFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKALGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLARETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDYDLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVATVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHAKKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGNELDAARHPLQIVKFKLDKKIYPSNMMRKGK
Protein: E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING-type E3 ubiquitin transferase MGRN1) (Q9D074)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). Acts also as a negative regulator of hedgehog signaling.
Subcellular location: Early endosome {ECO:0000269|PubMed:19422019, ECO:0000269|PubMed:19524515}. Note=The endosomal localization is dependent on the interaction with TSG101. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Cell membrane {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm. Nucleus. Note=In the cytoplasm, predominantly localized to the perinuclear region and discrete vesicular structures. In the nucleus, broadly distributed, but excluded from nucleoli.
Interaction partners:
- Protein smoothened
- Multiple epidermal growth factor-like domains protein 8
- Attractin
Sequence:
MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKEDADSPTEDGEKPRVLYSLEFTFDADARVAITIYCQAVEELVNGVAVYSCKNPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHVDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSSECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPISFSPVLAQSVDHDEHSSSDSIPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAGLDRIMESGLQKGKTQSKSPDSTLRSPSFPIHEEDEEKLSEDSDAPLPPSGVELVLRESSSPESFGTEEGDEPSLKQGSRVPSIDDVLQDGSPQHHGCSQPVPPADIYLPALGPESCSVGIEE
Protein: Variant surface glycoprotein (VSG), putative (Q580P0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MIGQWSKIFLIALALTSPALASFQADNAADLQLLCTAIALDGAEPTKLTTADSAETTIKHARALNMSAADETWQEIFVGGKSKNSWEAKKQKVTGEPFKSHWEADYDKWVEDKETVDSGTGQSKWLTLNPRPASAPALQAAAEKINSTLRQLLKQQAALETATTEATETYPNEAKDELIQALYGTGVTQPKFTDGKTIKHAATYANGCAKNAGLSIYGDVMCICGTQSADTSDQCADPVIAIKWSGGNDQSVISQLKAKCKTLKPAEYTAGDLEALVQRIVGRVRSAKGAGNDVIHYLGKVNLGTCTGANSQACAIYASDSGKHSAITGGLNIPWLNHLAKAAKALRKAEAAAKNTETSSKHIKILADAIQTAYSATRYNMMGKPAAAQTETQSKKTDGEDGKQHHCKQKTNQTKEECKKLGCDHDEKENKCKPKAGTEDKVAGTGDATTPNCASHTEKTKCEAENTGKSSPVCGWRKGKDGETEPEKEKCRSSSFLLNKKFALSMVSAAFVALLF
Protein: Poly(U) binding splicing factor 60 (E9PN18)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEQLNLADSGLVGKEARRCRRASPPMGMPSAWWLQNEAGCLFAARQVNGQQGGGSEPAAAAAVVAAGDKWKPPQGTDSIKMENGQSTAAKLGLPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTNLQMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIK
Protein: Epithelial cell transforming sequence 2 oncogene (Epithelial cell-transforming 2) (Protein ECT2) (Q6DRB9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MADSSILTLGPGRSILVDSSVYDSRMAETSKEQYFIGLHSDETEGVLPRVETRVVLVGEACKMAELEKALQDLNTPCIKTDNVCDFGDGENCEFETVFVLKDFQAPEYSFLYKNDSRILGPPAVMHCANKGEPLPFSSRPLYSMTMLNLSLCFTGFRKKDEVVALVNLVHHMGGTIRKDFDSAKVTHLIARSTHGEKYRLAVCMGTPILTPDWIRKAWEHRDDINFHAGNELFRTEFKVPPFQDCVLSFLGFSEEEKNNMEERTQKHGGRFQAVGDERCTHLVVEENSIKELPFTPSKRLYVVKQEWFWGSIQMDARAGESMYSYEKPESPAMKKAVSLLSLTTPNSGRKRRRLRETLAQLTKETEISPFPPRKRPSAEHSLSMGSLLDISNTPDTKSSGENAKIPKSSTPALPKQSARWQVSKELYQTESNYVDILATVLQLFKYPLEKEGQVGGPILAQEEIKTIFGSIPDIYEVHTRIKADLEELVMNWSEERSVGDIILKYSGELVKAYPPFVNFFEMSKETIVRCERQKPRFHAFLKINQSKPECGRQTLVELLIRPVQRLPSVALLLNDIKKHTSDDNPDKLTLEKAIESLKEVMTHINEDKRKTEGQKQIFDVVYEVDGCPANLLSSHRSLVHRVETIALGDKPCDRGEHVTLFLFNDCLEIARKRHKVITNFRSPLGQTRPPAQLKHITLMPLSQIRRVLDIQDTEECQNAFALVVRPPTEQENLLFSFQLTAEDTLKTTWLRTLCRQVANTICRADAEDLIQSTDPDSVQVSTKDMDSTLSRASRAIKKTSKKVTRAFSFTKTPKRVLQRAFMANGTPDERSPCPDADRMSRMSSSSTLATVHSPSMINLSSAFERKYHTFSRSTTHLI
Protein: LD21711p (Q8SX80)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSQTGSGSGGNNTSNSNNSSSGSGGSGSGSSTGNTASGSGNNNSTSAGGPPSSQGGNNGNGSGSSSSSSSGKSSAKMSIDHQATLDKGLKMKIKRTKPGTKSSEAKHEIVKATDQQQNGALGAGSNNSANEDGSSGSSSTNASSLGSTNSSSSASSGSSSSSGSSSSSSKKHLNNASSGSGSSSSGGGSQNNASGHASGGGSSGSSQSTPQGTKRGSSGHRREKTKDKNAHSNRMSVDKSAAAASAAGEKDTPEKCSGTGAGGSPCSCNGDVGAPCSHHACIRRAAHMSNSAGNANSSAGTGQSGGSSSMSAVPPGVFTPSAGSPSTGSPSTVVPAAASLLAATGAASSSASQMASSSAGGVGGSGGGANAPGPPGKESAGSIKISSHIAAQLAAAAASNSYSGSGANTNQGQNSNAGGNGGSESKAAAAAQAKLMAPGMISATMHHTISVPAGTGTGDDDTKSPPAKRVKHEAGASGAGGGKEMVDICIGTSVGTITEPDCLGPCEPGTSVTLEGIVWHETEGGVLVVNVTWRGKTYVGTLLDCTRHDWAPPR
Protein: Probable proteasome subunit alpha type-2 (O94579)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable proteasome subunit beta type-4
- Probable proteasome subunit beta type-2
- Probable proteasome subunit beta type-1
- Probable proteasome subunit beta type-7
- Probable proteasome subunit alpha type-3
- Probable proteasome subunit alpha type-5
- Probable 26S proteasome regulatory subunit rpn6
- Probable proteasome subunit beta type-3
- Probable proteasome subunit alpha type-4
- Probable proteasome subunit beta type-5
Sequence:
MTDKYAFSLTTFSPNGKLVQIEYALNAVNAGVTSVGIKATDGVVLATEKKPTSELAIGASLEKVCAITPDIGMVYSGMGPDFRVLVDKSRKVAQTTYKKIYNEYPPTKILVQEIASVMQESTQSGGVRPFGVSLLVAGMDEKGPSLYQVDPSGTYFAWKATAIGKSSTAAKTFLEKRYNDELELDDAVHTAILALKETFEGELTEDNIEIAVVSTKPTDSGIVGVPGGHFCRLSQSEIRDYLDQV
Protein: Uncharacterized protein YgaH (P43667)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Inner membrane protein YgaZ
- Transcriptional repressor MprA
Sequence:
MSYEVLLLGLLVGVANYCFRYLPLRLRVGNARPTKRGAVGILLDTIGIASICALLVVSTAPEVMHDTRRFVPTLVGFAVLGASFYKTRSIIIPTLLSALAYGLAWKVMAII
Protein: E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (Q8R4T2)
Organism: Rattus norvegicus (Rat)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (By similarity). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (By similarity). Promotes monoubiquitination of SNCA (By similarity). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (By similarity). Has some overlapping function with SIAH1 (By similarity). Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (By similarity). Regulates cellular clock function via ubiquitination of circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation. Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19224863}. Nucleus {ECO:0000305|PubMed:19224863}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250|UniProtKB:O43255}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase
- Calcyclin-binding protein
- non-specific serine/threonine protein kinase
- E3 ubiquitin-protein ligase SIAH1
- Prolyl hydroxylase EGLN3
- Hypoxia-inducible factor 1-alpha
- Ubiquitin carboxyl-terminal hydrolase 19
- A-kinase anchor protein 1, mitochondrial
Sequence:
MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGAGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ
Protein: RH19475p (Q8SX12)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSLPSIISIIRTIPIPILAVGEQSGKPNRSVARHIPGPNLEQLGQRASTAASEISRAHQLAMERGEKLNLLEERAERMANTAQDFSGTAHQLMLKYKDKKWYQL
Protein: 26S proteasome regulatory subunit 6A homolog A (26S proteasome AAA-ATPase subunit RPT5a) (Proteasome 26S subunit 6A homolog A) (Regulatory particle triple-A ATPase subunit 5a) (Tat-binding protein 1 homolog A) (TBP-1 homolog A) (Q9SEI2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (Probable). Interacts with transit peptides of proteins targeted to the chloroplast, and may be involved in the degradation of unimported plastid protein precursors. Plays a essential role in the gametophyte development. Involved in tolerance to zinc deficiency, possibly through alleviation of oxidative stresses or processing of poly-ubiquitinated proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9878390}. Nucleus {ECO:0000269|PubMed:9878390}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 7 homolog A
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome non-ATPase regulatory subunit 13 homolog A
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- 26S proteasome non-ATPase regulatory subunit 12 homolog B
- Proteasome subunit beta type-4
- 26S proteasome non-ATPase regulatory subunit 1 homolog A
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome regulatory subunit 6B homolog
Sequence:
MATPMVEDTSSFEEDQLASMSTEDITRATRLLDNEIRILKEDAQRTNLECDSYKEKIKENQEKIKLNKQLPYLVGNIVEILEMNPEDDAEEDGANIDLDSQRKGKCVVLKTSTRQTIFLPVVGLVDPDSLKPGDLVGVNKDSYLILDTLPSEYDSRVKAMEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKERFEKLGVRPPKGVLLYGPPGTGKTLMARACAAQTNATFLKLAGPQLVQMFIGDGAKLVRDAFQLAKEKAPCIIFIDEIDAIGTKRFDSEVSGDREVQRTMLELLNQLDGFSSDERIKVIAATNRADILDPALMRSGRLDRKIEFPHPTEEARARILQIHSRKMNVHPDVNFEELARSTDDFNGAQLKAVCVEAGMLALRRDATEVNHEDFNEGIIQVQAKKKASLNYYA