wanglab/gogpt-training-data huggingface dataset:
Protein: Avr9/Cf-9 rapidly elicited protein (Q56XA0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mitochondrial uncoupling protein 4
- Arabinogalactan protein 16
- Ethylene-responsive transcription factor ERF017
- Ras guanine nucleotide exchange factor Q-like protein
- Transducin/WD40 repeat-like superfamily protein
Sequence:
MNSMFSAFDAMCAEIMGKKVTAASYVYRSERNSASSSSSVGGQNASLSLKKDEKASKNMDLPTKTPRFALELDGLHCFETIVRS
Protein: BtR175 (Q9XY09)
Organism: Bombyx mori (Silk moth)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MGVDVRILATLLLIYAETVLAQERCGFMVAIPRPPRPDLPELDFEGQTWSQRPLIPAADREDVCMDGYHAMTPTYGTQIIYMEEEIEGEVPIAKLNYRGPNVPYIEPAFLSGSFNLLVPVIRRIPDSNGEWHLIITQRQDYETPGMQQYVFNIRIDGETLVAGVSLLIVNIDDNAPIIQALEPCQVDELGEARLTECVYVVTDADGRISTQFMQFRIDSDRGDDKIFYIQGANIPGEWIRMTMTVGINEPLNFETNPLHIFSVTALDSLPNTHTVTLMVQVENVEHRPPRWVEIFAVQQFDEKTAQSFPVRAIDGDTGINKPIHYRLETAEEDTFFHIRTIEGGRSGAILYVDPIDRDTLQREVFQLSIIAYKYDNESSATAANVVIIVNDINDQRPEPLFKEYRLNIMEETALTLNFDQEFGFHDRDLGQNAQYTVRLESDYPADAAKAFYIAPEVGYQRQTFIMGTANHKMLDYEVPEFQRIRLRVIATDMDNEEHVGVAYVYINLINWNDEEPIFEHSVQNVSFKETEGKGFFVANVRAHDRDIDDRVEHTLMGNANNYLSIDKDTGDIHVTQDDFFDYHRQSELFVQVRADDTLGEPFHTATSQLLIHLEDINNTPPTLRLPRGSPNVEENVPEGYIITSEIRATDPDTTAELRFEIDWTTSYATKQGREANPIEFHNCVEIETIYPAINNRGSAIGRLVVKKIRENVTIDYEEFEMLYLTVRVRDLNTVIGDDYDESTFTITIIDMNDNPPIWVPGTLEQSLRVREMSDAGVVIGTLTATDIDGPLYNQVRYTMKANEGTPENLLMIDFYTGQITVKTSGAIDADVPRRYNLYYTVVATDRCYAEDPDDCPDDPTYWETPGQVVIQIIDTNNKIPQPETDQFKAVVYIYEDAVSGDEVVKVIGSDLDRDDIYHTIRYQINYAVNPRLRDFFAVDPDTGRVYVYYTTDEVLDRDGDEPQHRIFFNLIDNFFQQGDGNRNQNDAEVLVVLLDVNDNAPELPEPDELSWSVSESLTKGTRLQPHIYAPDRDEPDTDNSRVGYAIISLTIANREIEVPELFTMIQIQNVTGELETAMDLRGYWGTYAIHIKAYDHGIPQQMSNETYELVIRPYNFHAPVFVFPKHGATLRLARERAVVNGLLATVDGEFLNRIVATDEDGLHAGQVAFEVVGDTEAVDYFHIVNDGENSGTLMLKQLFPEDIREFEVTIRATDGGTEPRPLSTDCTFSVVFVPIQGEPIFPTSTHTVAFIEKEAGLLERHELPRAEDRKNHLCSDDCHNIYYRIIDGNNDGHFGLDETTNVLFLVKELDRSVSETYTLTIAASNSPTGGIALTSTITITVNVREADPQPYFVRDLYTAGISTSDSINRELLILQATHSENAPIIYTIDWSTMVTDPTLASVRETAFILNPHTGVLTLNIQPTASMHGMFEFQVVATDPAGYSDRANVKIYLISTRNRVFFLFVNTLEQVEQNTDFIAQTFSAGFEMTCNIDQVVPATDASGVIMNGITEVRGHFIRDNVPVPADEIETLRGDMVLLTAIQSTLATRLLVLRDLFTDTSPAPDAGSAAVLYALAVLSALLAALCLLLLVIFIIRTKKLNRRLEALTVKKYGSVDSGLNRVGIAAPGTNKHAVEGSNPIWNETIKAPDFDSMSDASNDSDLIGIEDLPHFGENNYFPRDVDEFKTDKPEDIVATHNNNFGFKSTPFSPEFANQFQK
Protein: ATP synthase protein 8 (A6L) (ATP-associated protein 1) (F-ATPase subunit 8) (P00856)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Subcellular location: Mitochondrion membrane; Single-pass membrane protein.
Interaction partners:
- ATP synthase subunit 9, mitochondrial
- ATP synthase subunit 4
- ATP synthase subunit H
- ATP synthase subunit J, mitochondrial
- ATP synthase subunit a
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit d
- ATP synthase subunit alpha
- Mitochondrial ATPase complex subunit ATP10
- ATP synthase subunit delta, mitochondrial
Sequence:
MPQLVPFYFMNQLTYGFLLMITLLILFSQFFLPMILRLYVSRLFISKL
Protein: Ribosome biogenesis protein ERB1 (Eukaryotic ribosome biogenesis protein 1) (Q04660)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular location: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:18448671}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:18448671}.
Interaction partners:
- Protein MAK16
- 25S rRNA
- Pescadillo homolog
- rRNA-processing protein EBP2
- Nucleolar complex protein 2
- Ribosome biogenesis protein MAK21
- Ribosome biogenesis protein RLP7
- ATP-dependent rRNA helicase SPB4
- Ribosome biogenesis protein RPF2
- ATP-dependent RNA helicase HAS1
Sequence:
MMAKNNKTTEAKMSKKRAASEESDVEEDEDKLLSVDGLIDAEASESDEDDDEYESAVEEKESSSDKEAQDDSDDDSDAELNKLLAEEEGDGEEDYDSSEFSDDTTSLTDRLSGVKLQTIVDPNIYSKYADGSDRIIKPEINPVYDSDDSDAETQNTIGNIPLSAYDEMPHIGYDINGKRIMRPAKGSALDQLLDSIELPEGWTGLLDKNSGSSLNLTKEELELISKIQRNEQTDDSINPYEPLIDWFTRHEEVMPLTAVPEPKRRFVPSKNEAKRVMKIVRAIREGRIIPPKKLKEMKEKEKIENYQYDLWGDSTETNDHVMHLRAPKLPPPTNEESYNPPEEYLLSPEEKEAWENTEYSERERNFIPQKYSALRKVPGYGESIRERFERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWTT
Protein: 3-dehydrosphinganine reductase TSC10A (EC 1.1.1.102) (3-ketodihydrosphingosine reductase) (KDS reductase) (3-ketosphinganine reductase) (Q0WRJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). Required for sphingolipid biosynthesis. In plants, sphingolipids seems to play a critical role in mineral ion homeostasis, most likely through their involvement in the ion transport functionalities of membrane systems in the root. Lacks stereospecificity and can also produce L-threo-DHS in addition to D-erythro-DHS.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:21421810}; Multi-pass membrane protein {ECO:0000305|PubMed:21421810}.
Interaction partners:
- Long chain base biosynthesis protein 1
- serine C-palmitoyltransferase
- Long chain base biosynthesis protein 2b
- Long chain base biosynthesis protein 2a
- Sphinganine C4-monooxygenase 1
- Sphinganine C4-monooxygenase 2
- Alkaline ceramidase
- Neutral ceramidase 1
- Sphingosine kinase 2
- Sphingosine kinase 1
Sequence:
MAAISPLFLLFLIPIIPLSLLAILALIVRPRPIKIPIKSRHAFITGGSSGIGLALAHRAASEGARVSILARSGSKLEEAKKSIQLATGVEVATFSADVRDYDAVSKAIDESGPIDVLIVNQGVFTAKELVKHSPEDVKFTIDVNLVGSFNVIKAALPAMKARKDRGPASISLVSSQAGQVGVYGYAAYSASKFGLQGLAQALQQEVISDDIHVTLIFPPDTNTPGFEEEQKSRPEVTAIIAASSGSMETEEVAKKAMDGIKAGNFTVSCNFEGFLLSLATTGMSPQRSFWLAFLEVITAGPIRLIALFFQWDWYKAIEKWSKTKTK
Protein: Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (P99027)
Organism: Mus musculus (Mouse)
Function: Plays an important role in the elongation step of protein synthesis.
Interaction partners:
- Large ribosomal subunit protein P1
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL14
Sequence:
MRYVASYLLAALGGNSSPSAKDIKKILDSVGIEADDDRLNKVISELNGKNIEDVIAQGVGKLASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEKKEESEESDDDMGFGLFD
Protein: Protein dumpy-20 (P34807)
Organism: Caenorhabditis elegans
Function: May be directly or indirectly involved in cuticle function.
Interaction partners:
- Cuticle collagen rol-6
- Band 7 domain-containing protein
- Protein unc-119
- Myosin-3
Sequence:
MEGHSNTSVILHTYQQQQPQQLISSIIPQTLSDGYGISAPISQADCSGNSNFVNTNPWNNTTFQAYQTDAQFTNEISVLNYPNVYDDFSKESSNGILSDPSLHGSNSSSSTSDVGSSVDCSISPEPILMPSVKRGRPTENPCWAYFHRIDDQLVKCRLCTKVVRSACATNMTKHLERHHADDYQKVTGQLKLFRMNDVGIRSKMHYEVADNPLSTLPVVTNSYILPKMEPMDTFDPSQYYGMQQDPTLNQQQFIQFEQPQASIDPQTWPLTHFWQNTAQTNIMSHLGEASTSTLGSSVIQEAHKMNPDSNDKSFQLDLEQQNCVIIEQKLDDKPRVTKPTTKPYQKRNRKTEHPVWAFFKRTGDGNAECIICQGVVKSPCSSNFMRHLMRHHSTEYNDVYLKWIEKRNITHPGIHCTSVPPPAFINNETSRTEQTTFSVK
Protein: ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (O97285)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- mRNA-decapping enzyme subunit 1, putative
- mRNA-decapping enzyme 2, putative
- Trailer hitch homolog, putative
- U6 snRNA-associated Sm-like protein LSm1
- U6 snRNA-associated Sm-like protein LSm7, putative
- CCR4-associated factor 1
- NAD
- CCR4-NOT transcription complex subunit 4, putative
- CCR4-NOT transcription complex subunit 5, putative
- CCR4-NOT transcription complex subunit 1, putative
Sequence:
MSYKTNCTNSNANTNTLNSSSNYNKIDDNIILDEEWKKKILEPLKDLRYKTEDVTKTKGNEFEDYFLKRELLMGIFEKGYEKPSPIQEESIPVALAGKNILARAKNGTGKTAAFAIPLLEKCNTHKNFIQGLILVPTRELALQTSAMIKELGKHMKVQCMVTTGGTSLREDIMRLYNVVHILCGTPGRILDLANKDVANLSGCHIMVMDEADKLLSPEFQPIVEELMKFLPKEKQILMYSATFPVTVKEFRAIYLSDAHEINLMDELTLKGITQYYAFVKERQKVHCLNTLFAKLQINQAIIFCNSITRVELLAKKITELGYSSFYIHARMSQTHRNRVFHDFRNGACRCLVSSDLFTRGIDIQSVNVVINFDFPKNSETYLHRIGRSGRYGHLGLAINLITFEDRFNLYKIEVELGTEIQPIPNEIDPSLYT
Protein: Gap junction protein (F1QL21)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}.
Interaction partners:
- Gap junction alpha-1 protein
Sequence:
MGDWSLLGNFLEEVQEHSTSVGKVWLTVLFIFRILVLGTAAESSWGDEQSDFMCDTLQPGCTNVCYDRAFPIAHIRYWVLQIVFVSTPSLIYMGHAMHTVRMEEKRKQKEQEEKAEAGKGEKEYLEHKEKFENTKTKIHLKGALLQTYVLSIVIRLVMEVTFIVIQYMMYGIFLDALYPCSMLPCPNPVNCYMSRPTEKNVFIVFMLVVAAVSLLLSVIELYHLGWKQCKKCLRKHADKHANDKIQNVKAVSAIEPIRTSIPMDLAENIQPRLSQTCTPPPDFNQCLRSNQGPTSPPHLHSHHLHHIHQTCQPFTNHLAHQQNSVNMAAERHHHSHDGLEPAVDFLQMHYGSPEARVRSEMTPSTPSTPSSHPGFFRDKRRLSKTSGTSSNRLRPSDLAV
Protein: Zgc:123326 (Q3B7F0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAAAAGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWRGMIIGPPRTIYENRMYSLRVECGPRYPETPPFVRFVTKINLNGVHNSNGVVDMRAVSSLAKWQNSYSIRVVLQELRRLMMRKENMKLPQPPEGQIYSN
Protein: Insulin-like growth factor 1 (Insulin-like growth factor I) (G8HMZ1)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU000406}.
Interaction partners:
Sequence:
MEKINSLSTQLVKCCFCDFLKVKMHTVSYIHFFYLGLCLLTLTSSAAAGPETLCGAELVDALQFVCGDRGFYFSKPTGYGSSSRRLHHKGIVDECCFQSCDLRRLEMYCAPIKPPKSARSVRGPRHTDMPKAQKEVHLKNTSRGNTGNRNYRM
Protein: Superoxide dismutase [Cu-Zn] 3 (EC 1.15.1.1) (Copper/zinc superoxide dismutase 3) (Q9FK60)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: Peroxisome {ECO:0000269|PubMed:9765550}.
Interaction partners:
- Superoxide dismutase 3, chloroplastic
- Superoxide dismutase 1, mitochondrial
- Superoxide dismutase 2, chloroplastic
- Superoxide dismutase 1, chloroplastic
- Superoxide dismutase 2, mitochondrial
- Copper chaperone for superoxide dismutase, chloroplastic/cytosolic
- Superoxide dismutase 2, chloroplastic
- Superoxide dismutase 1
- Catalase-2
- Catalase-1
Sequence:
MEAPRGNLRAVALIAGDNNVRGCLQFVQDISGTTHVTGKISGLSPGFHGFHIHSFGDTTNGCISTGPHFNPLNRVHGPPNEEERHAGDLGNILAGSNGVAEILIKDKHIPLSGQYSILGRAVVVHADPDDLGKGGHKLSKSTGNAGSRVGCGIIGLQSSADAKL
Protein: GH21475p (Serpin 77Bc, isoform A) (Serpin 77Bc, isoform B) (Q9VPH9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Accessory gland protein Acp76A
- Serpin 28F
- Serpin 38F, isoform A
- Male accessory gland protein
- Accessory gland-specific peptide 26Ab
- Accessory gland-specific peptide 26Aa
- Serpin 77Bb
- IP10416p
- glutaminyl-peptide cyclotransferase
- trypsin
Sequence:
MKLGFLGLFGMVLSLRAHICANTVDTKSLLQKMTDARLQFALNLLQMESTHLNLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLAIYVDYPTLRRWYEDVRAYHYLNSENTKLFSLRYAYYDDVGDLELVKGYNSVVLEGVGEGNVVLREGRPRGVDFDQGASIIINDDIDKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAKWKYPFDKSQTKVEQFYNAGGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPFGEHELVMIVILPKPSQRVSLVLKQLKNLGLHRLLEELEASKNESDVEVKLPKFDTRSVLSLEDTVYEAGLTDLRNEFADLGRMLIPTGDRGAYLSLYHQFARIVVDEEGLPNAVPQKSSGTNNIKFHINRPFAYLVLQRTHKLLIHSGVFREGEIQ
Protein: Pleckstrin homology domain containing, family A member 5 (A0A0N4SW19)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MTSEDKKERPISMINEASNYNMASDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIAMLTAEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITTDSASTKETNNIPNHRVLIRPEVQNHQKNKEISKIEEKRALEAERYGFQKDGQDRPLTKINSVKLNSLLSEYESGPDCPPQNVHYRPINVNSSDGKAVNVSLADVRGGSHPNAGPLATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRAQILARCPEGYRTLPRNSKTRPESICSVTSSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPRHGCLSSPKAMVQVSDQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEVTSPIQRGDVTIDRRHRPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRTVSVMTLLIICLLYLLPRKT
Protein: FI04407p (Serine-arginine repetitive matrix 1) (Q9VU43)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD23870p
- FI21285p1
- RE04053p
- Serine-arginine repetitive matrix 2/3/4, isoform F
- Regulator of nonsense transcripts 1 homolog
- Pinin, isoform B
- LD40489p
- Splicing factor 3B subunit 1
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor CWC22 homolog
Sequence:
MMFTGTNQQQDTRFSDKEKKLMKQMKFGDCLNKRVDMSKVKLDVLRPWISKKITDILHIEDDVVVEFVYNQLEEEKYPCPKKMQINMTGFLNGRNARQFMGELWALLLSAQESDSGIPAEFIQQKKDEILKREEEQRQRDRSRSRSRSRSQRDSSRRDRQRDRSKSKSRSRSRSMKPANNNGSVPSAAREAAANAAAKIRKRGSSSAARPGSRERRSSRRPRSRSRSRSRTAGKKTGSVEPAPAKTVNGRHSTDKSSPVPPASKNKSRSRSHSRSRSPRSRSRSPSAKRSRSRSSSRRSRRRGRSSSISLSPERNQDQFEHRRNKNSVQNKRQYRNNRGDSASSMERGNDRGRQFGGGGGGRRGGRRFSPRGRSPMRQDNGGGNGGNRFQRSNSRRRSRSRRLSRSPMRYSRSPRRFNNRRRSPMMNFRGGGRGGGRGGGHRQMWQHRGGSPNFRGGGRIHWQARHSPGGGGRGGGGGMGRFDRRQSPQQNRYNRDHRQSPMQQNQPFRKQFSPHQGPGRRFSSPQQRRNSRDRRPNSRERRSSPGGGGGHMNRWDNPPPARNRRSSSGSSAGGRQQRQRSASPPEKRRSSHSRSRSLSRNRSRSRSSSQHSRKRESPIGRSSVEYAGPAVNTIDLCREEQQRKNKPETIIVLDEGPAVRSSYASLSRTPSPFLKPHERLAAAKAAAAASAAVPKKSRDQSQSSSSDSSAESDDSEEQPRRKKQPTNMETSKGKKEKVRRSSESSTSSEQSDDEDNSSGDERLKKKLQQRKSKEAAALKGKEKEHEKEKDKRRSDKKSKRGAISSGDEESTSSRKRGHKKTRRDEAGDNSDSEDEHVPKKKRKKAKKPADSSDSDSEASSKRKKHKKHKKHSKKSKKHKKHKRKCSAGKSRADSSSQGSSDEDEQLPHSVAAKRNGNAGKLALLLPGASGAGVINEDLEKQLRERALKSMKKLD
Protein: Glutamate receptor ionotropic, NMDA 3A (GluN3A) (Glutamate receptor chi-1) (N-methyl-D-aspartate receptor) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L) (NMDAR-L1) (Q9R1M7)
Organism: Rattus norvegicus (Rat)
Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11160393, ECO:0000269|PubMed:11588171}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13224}. Postsynaptic cell membrane {ECO:0000269|PubMed:11588171}. Postsynaptic density {ECO:0000269|PubMed:11588171}. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. {ECO:0000269|PubMed:11160393}.
Interaction partners:
- Disks large homolog 4
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2D
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 3B
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Glutamate receptor 4
Sequence:
MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQEGGRAGAQRDDPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGAETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLPQRRRELPASLTTNGKADSLNVTRSSVIQELSELEKQIQVIRQELQLAVSRKTELEEYQKTNRTCES
Protein: Skp1-related protein (G5EG39)
Organism: Caenorhabditis elegans
Interaction partners:
- Skp1-related protein
- Cullin-1
- Cullin-6
- RING-box protein 1
- F-box/WD repeat-containing protein lin-23
- Skp1-related protein
Sequence:
MSAEVAAVEIQEAPVAAPIMYKVESNDGTVFEISDEAVKQSNTLSNLISTCAPEDVASMDPIPITNVTGNILKMVIEWCEKHKGEALPVDDDSVPKHITVPEWDTNFLKIDNEVLFDLIVACNYLDVPGLMNYGCKMVAMMAIGKSPDELRIIFAIPTDEEDEAAERAAKEKAEAEKKANAEKDAAEPSTSK
Protein: Auxin-induced protein 5NG4 (Q6J163)
Organism: Pinus taeda (Loblolly pine)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Detected in the periphery of cells and punctate structures throughout cytoplasm. {ECO:0000269|PubMed:14722770}.
Interaction partners:
Sequence:
MASNIMQRCNVFMSERVKLHAAMLALQFGYAGFHIVSRAALNMGVSKVVFPVYRNILALMLIGPCAYFLEKKERPALTLSFLIQFFLLALCGITGQSRILSLRIVLHIPTFASAIQNSVPAITFIMAAALRLEKVHISRRDGLAKIIGTVACVSGATIITLYKGPPITHIWRPNLEVTASYFKAFQGNDLSAKSENWTLGCIYLLGNCLAWSGWIVLQAPVLKRYPARLSVTSFTCFFGVIQFLIIAAFFETDLEHWKIHSGGELFTILYAGFVASGIAFSVQIWCIDRGGPVFVAVYQPVQTIAVAIMASIILGEQFYLGGIFGAILIIIGLYLVLWGKSEEKRLGLLQAKSSMVPENQPDNMDQSATLIINSSNGIKPNTSSSLTQPLLLDTSYKTVNIPSPSDEPQP
Protein: LD23158p (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform B) (Q9VYW5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform B
- Protein Turandot Z
- Misexpression suppressor of ras 4, isoform A
Sequence:
MDVPDDNFGPSKPCDKQPLAGNSSSATNSSSHTGGNGNVDSAFESSTAAGPSSGANQSSTGGAIDEQGSIGEQSAGVGQNIIEGDLLVLNANSTNVDLSTHRDGSSFKDSNTEQGKKSTMIKTSKTLNDKSQFERRRRRGRQRERHREPSTHRDDLEPCDLGLMGWTGEFPKLTPISNIESNSDKEPLSTAKPGVLPWSGLKVFPRVEPQEETAAGTTKPAHITNKSEEQQQQPSLTTPIMTSPLDASQGELDAAIKSPLNAKKSPNATGIATTSKSSTTPTNMQPSDLYNQVEDKKEDTTKKQAEADHTLHKSLKDARIVKRSMSTHSPPEHSRRSVRFSSHTPLTDETNIMKETSTETSLKVIFERLKQTGVERDLFIPSSENPRPRSNGSPVPKVAEMEHVAVVKCKTVAKQGAVVKGKAGLANPSNVMPQTPALTVTGKRVSKPKVPKGASPPSEGWTSTRAVKGNSRADYTNSSSCGSPIGNTNIRRRRAHAKAAPDKSKPCVRCAASVHPSGPKLCKKCIYEKGYANKKWMKKTGGNEDHYDDDDDSDFSMIEVTLENEISVQQAEKKQLENVNKQTVIKEQEVVVIGGRKAIAIIADPIGCNLKVIPNRQNLAGLKKISKDKCSSSLVQSLGDCHIGCQIVMAVMKIMTMKDRVNMAQVCKTWAMISQDKSVWRTVMLRDTHISNWPRFIRELANNCTRELDMLGVILPNPPDILATLDISVLKALRVLRTCPVDDQFLFKVFRELPQLLELRAICYSPTFNFLNLARQWSKIRVLQILMTDHRSKVESLDSLGDLVHLTELNIRGVNYIGSQDFRFLKKLVNLKVLVLSSCQGMDTEEFGQQVLPFLTSLRRLRLENKHMINTTFPLYHIMCGVAAACSVQQLELVNVEVDDLLTSLIGMCTTVTHLLLVPKCLQNSANVIYSVMRAVRENASQLRVFRLGLVTQLLSATGELYRGSKKDVIPVERPVPGIPLDDDLNYCAPDDRCIETDHTECVTFLPAKRLLMILRDVAPTTFVTFVKVNMFNSTMVTFLKRPQLKNK
Protein: Probable cysteine protease atg4 (EC 3.4.22.-) (Autophagy-related protein 4) (Q9P373)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of atg8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). The protease activity is required for proteolytic activation of atg8: cleaves the C-terminal amino acid of atg8 to reveal a C-terminal glycine. Atg8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of atg8 during macroautophagy: atg8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of atg9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. Atg8 delipidation by atg4 also recycles atg8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated atg8 that is required for autophagosome formation at the PAS (By similarity). Plays a role in meiosis and sporulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Preautophagosomal structure {ECO:0000250|UniProtKB:P53867}.
Interaction partners:
- Autophagy-related protein 8
- Serine/threonine-protein kinase atg1
- Putative lipase atg15
- Autophagy-related protein 3
- Ubiquitin-like modifier-activating enzyme atg7
- Ubiquitin-like protein ATG12
- Autophagy protein 5
- Autophagy-related protein 9
- Autophagy-related protein 2
- Autophagy-related protein 18
Sequence:
MELMARFLERYLHFAPTNTEPPGTLIWFLGHSYKIEDSQWPEKFLYDSFSLITITYRSGIEGLENMTSDTGWGCMIRSTQTLLANCLRICYPEKQLKEILALFADEPSAPFSIHQFVTMGKTLCDINPGQWFGPTTSCSCVARLSDQNPDVPLHVYVARNGNAIYRDQLSKVSFPVLLLIPTRLGIDSINESYYDQLLQVFEIRSFVGITGGRPRSAHYFYARQNQYFFYLDPHCTHFAHTTTQPASEETFHSATLRRVAIQDLDPCMIFGFLIRDEEEWHSFEANQKYFADIVQIFDSEPQPVETHDDFVLDENVEDHL
Protein: GH18470p (Q8SXA8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus membrane {ECO:0000256|ARBA:ARBA00004126}.
Interaction partners:
Sequence:
MGNSEFHQTIGELVEWLQRTEQNIKASEPVDLTEERSVLETKFKKFKDLRAELERCEPRVVSLQDAADQLLRSVEGSEQQSQHTYERTLSRLTDLRLRLQSLRRLSGIYIVKLGAVLGYEGDNLGVPLHMLSSELLDNTTLSTSSMQAAAPNTENANNTDGGDAVDGDVINTTVLARGARFLGRVARASLPIQALMLLLLGVATLVPHGEDYTCMFSNTFARSLEPMLSYPHGPPPT
Protein: chitinase (EC 3.2.1.14) (Q700B8)
Organism: Serratia marcescens
Interaction partners:
Sequence:
MSTNNTINAVAADDAAIMPSIANKKILMGFWHNWAAGASDGYQQGQFANMNLTDIPTEYNVVAVAFMKGQGIPTFKPYNLSDTEFRRQVGVLNSQGRAVLISLGGADAHIELKTGDEDKLKDEIIRLVEVYGFDGLDIDLEQAAIGAANNKTVLPAALKKVKDHYAAQGKNFIISMAPEFPYLRTNGTYLDYINALEGYYDFIAPQYYNQGGDGIWVDELNAWITQNNDAMKEDFLYYLTESLVTGTRGYAKIPAAKFVIGLPSNNDAAATGYVVNKQAVYNAFSRLDAKNLSIKGLMTWSINWDNGKSKAGVAYNWEFKTRYAPLIQGGVTPPPGKPNAPTALTVAELGATSLKLSWAAATGAFPIASYTVYRNGNPIGQTAGLSLADGGLTPATQYSYFVTATDSQGNTSLPSSALAVKTANDGTPPDPGAPEWQNNHSYKAGDVVSYKGKKYTCIQAHTSNAGWTPDAAFTLWQLIA