Protein: E3 ubiquitin-protein ligase RING2 homolog spat-3 (RING domain-containing protein spat-3) (EC 2.3.2.27) (H2KYH3)
Organism: Caenorhabditis elegans
Function: E3 ubiquitin-protein ligase playing a central role in histone code and gene regulation (By similarity). Involved in ubiquitination of histone H2A. Plays a role in the formation of the male-specific genital sensilla (simple sense organs) known as rays. Required for normal migration of the hermaphrodite specific neurons (HSN) and for extension of some neuronal processes. Represses vulval fates in hypodermal cells that do not normally contribute to vulval development.
Interaction partners:
- Polycomb group RING finger protein 3 homolog mig-32
- Chromo domain-containing protein cec-1
- RanBP2-type domain-containing protein
- Polycomb protein mes-6
- Histone-lysine N-methyltransferase mes-2
- TEP1-F
- Probable histone-binding protein lin-53
- RING-type E3 ubiquitin transferase
Sequence:
MDDSPGPSTSKSARDKAENAEENTSDSSSDSEVSSASEKSEESRPSSEKKKVITRVIPVRPPTRDKGHRVNLLESGNESETKSLYQRAKEGIPSYKGKPEIKLPTTSEQYYDLEEVLMNPARMEGRELTLNAYDAVRNKYNVLPGKSVCEADLQKVIGSFSCDVCQELIQGSIMTKKCGHRFCDQCILVAFMRSGNTCPTCRQNLGSKRELQQDPRFDQLIYQVVESRSIVGRMMAENREHEKDVYFGRKGYIEGGSDWNKRYGIDPNSKLKAPRPLKSAGRKKIRWFHESDEDGSVRKVMESKKGAPKEDDTNYLENDKEGTSVAAEKEVLEEGEMDFPIEIKSSDEEQTDLDDEEESMLDSDFEISDNEDVSKPSCSTSKKTTNRSRDSSESDNDSRDNELQKKKRKMKRKNVPKTDGSDVSNESFDEDASGEVVATKLIKESKKKPCGRPKKKFAPELIEGDIPTPSEDSLTSSDEERDDNAADPYAFVFQKEFNRDPRRDGHPEKDKLYNFDFMIDMNHQVDRKFEKDGEIHVISDDSNSEHESDEAEDRESSIDSEHEKEISKFLSHRQPLPNPTSVDDDCQVITVVKKDVKQSAITSKPGETSPDSSSKIEEKPDKVSEEVSDDEMTPEHITADKGTDTFLNNIMEHDDEMYGGYLFRPGDTGISRPKVQRAPGTNRLSMNVCPEAVYVVYPQPVLKEGKKKLVIPPEDYEISSDETVTLSDSEETSPSAEMEQSETSEAGPSTIIKTSGTERETQGSSSPSEPSTSRDRKMHKRKLDTRRRKLADDSDLSDFDVFSIDGNELVATGKPIIKHKVFYDSANRMPSKSNLDFTGRRNAREIPMEEISRLAEEQVAHEEYKIHRRRQVVLEAVEAASKKLNVYVDTTEEEEIEEEETPEEEVVKVASPTAPIATENPTTSTAPFEEGVAMKETPIEEIFFDPDEPCSSAQAAQRELIIERVGKEQQIIEDSLEQNRKPSSKTVKESESREAQEPRIEKDEMESEQQKKDADNPTVEVDKESEASSSESDKSDFEDETLDAQSKTVKISLKHEKTVSDEEIEDFDTKFGEFVATADAKMIKRTIGEYVSTEFLKLVAQQPAVTDEVLALGFCVRNTDQEFSTIKETGKRTNKNPDDVRLESMVKNFRESFAAKHRPVPRKLPTNIERMYIERAHMVKYKHVVDMEPLHMKILIALQKQQIAATCANLSQPVTVTPEEHAEQVQLLHNLQNPSILRPLLNNPQFALTLHKAQQQAIQQQRAQQKAQTQKELAARQAEQARVEELARKRIAQEDAEKALRQKGEQMSNVSGIPVSSDQNAQSSNAQQTGLIENQTTTTNSDSLTRPNTLADNSHLGESQQIPVIESIQSSTSEALKESENYKDMPILTPASTVSSKSSAPATRRPSRPCSSYDRPSSPSVVIRERLGSDGALINRPPNRCNIDKSRSRSPISRAPVETVRINDHGQNETILAGNITHTVETTILEEGTSIGQDSTIRYDGECSTTQYIDKTIDLDNSKNGTNVDEEQSNVLKLRENDLNREMLRYANRYHPSTMLAMGNLSINERHNKVQQVLASQELQDLIARHTSGAVSQTQVEVVGGEGVCAGTSDAIGETDEDDDVEEEPEFTVDQLELAKKILKQRQGLESSEDSDSDEDMVYDNVDGSVIRRAPHKKRETRKKKNIFVPNIPPKIRRKYVDKKIEMERAKYRARIKSQKMASIRIAVPQKPTQQFATPQQPVRGPGKHSAAAAARATPKPKKAKMSNVQMSIVQPPLPLHQLQGHMSAPTKITAVPNVAAGFHQNQQQLYSDMAQAPQSTPIRTTPQPGTGSAPQAQTPQSHLAQLGQFVNGANQQQAPQQQGMYTAAQLQAMQAAVAQTAQAAQAAYAAEAAYQAQVAQQARAAPPQQLVQRQVPVGHPGQVNVPMPAQMLNQGNPQMAVNPAQAQMMDERRKMEEVNAVYHLMQSRGQFPPTNQELFQVQFAQAQADLRSAAAQAAQAAQAQAQMTNMRAQAEAVARQQAMMKQEQARAQAAAKEAARLKAETEAAKAKVQAEAEARRKAEQEMRVRQAQAAQTQAAQAQAQSQAHAQNQAQTQAIVEIQRMIQSGQPLSMQQMQQLQQMSQVQMQHAQQVQQMQQMQMQQLQMQQFAARMQQGTPKPAVSQQAVQQGMPAGIQGMPTGMGMQQLQGLGMPGMQLPQQAGQSQQTSQAQQQQLFMQLQLQQQQLMQHQLQQQLQMQQHQQHQQQQQQIQMQQQQQLAQQGLVPNVSSAWLQQQAQLAQQQQQVVQQNLLMRVPSAQTPVAPRAPTVAPQSVVQQAPAPATPIAISVATTQVTRPETVEPFRSISSGTGTGTERINNNVELELWPTNGYSEKKRKEGSQASPIFGASAGDSTFYHVACLIRSRSACNADDVGSLWVLRLEDQTLLQFQLQQTLAEAQRFVGKQHLVIFYDDVMSGEVQQSKEYVINREFKPSNRQIPN