wanglab/gogpt-training-data huggingface dataset:
Protein: Nuclear receptor subfamily 1 group I member 2 (Nuclear receptor subfamily 1, group I, member 2) (B0V1H8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
- Cytochrome P450, family 3, subfamily c, polypeptide 1
- Cytochrome P450, family 3, subfamily A, polypeptide 65
- Cytochrome P450 1A
- Nuclear receptor coactivator 3
- Nuclear receptor coactivator 1.
- Nuclear receptor coactivator 2
- Aryl hydrocarbon receptor 2.
- Nuclear receptor subfamily 1 group D member 2a
- Peroxisome proliferator-activated receptor gamma
- Cytochrome P450, family 2, subfamily AA, polypeptide 1
Sequence:
MSRLYDMCLLQLRMSKEMEELSPLDDSGHGDGSEEETEEDDEPKICQVCGDKSTGYHFNAMTCEGCKGFFRRAMKRPAQLCCPFQSACVITKSNRRQCQSCRLQKCLSIGMKRELIMSDEAVEKRRLQIRRKRMQEEPVTLTPQQEAVIQELLNAHKKTFDMTCAHFSQFRPLDRGQKSVSESIPVTNGSWIDHRPIAEDPVQWVFNSTSLSSSSSSCQSLDKEKKHFKSGSFTSLPHFTDLTTYMIKNVINFGKTLTMFRALVMEDQISLLKGATFEIILIHFNMFFNEVTGIWECGPLQYCMDDAFRAGFQHHLLDPMMNFHYTLRKLRLHEEEYVLMQALSLFSPDRPGVTDHKVIDRNQETLALTLKTYIEAKRNGPEKNLLFPKIMGCLTEMRSMNEEYTKQVLKIQDMQPEVSPLWLEIISKDT
Protein: Fuseless, isoform A (Fuseless, isoform B) (Fuseless, isoform C) (Fuseless, isoform D) (Fuseless, isoform E) (Fuseless, isoform F) (GH14865p) (Q7K3S3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLPTDKGSLTAGRPQKSHCHGSVSVSDQQLLQHLHPHTHPRPVHLPPAHATHSPACEKRLEAETPRRDLHELLLELLDMMMSCLVVAPCVIAYWRGTWELMFVYLFPGSLPLSAMASFLIGGLGHFFFTVTQNFFKEHIHPDRRRLTYYAVSRLYTAVFGIVCVNMWRGAWLLCDWLTSVDSLIIVSVVTAIALIFLVATRTLRNLGAAPYTVTMDHKSDYFEVDTMFKIPGFHQPGLYILDTLFSVFVIGSLVVIAWRGVWGIFDLLLFPADKAKSAWGSLLIGYLTVFVTFLIHPLMRYVCRRISGILKLIICDIYYLMTFFGAVNAWRGIWNLLDVYLYPDNKLLSFWLTHIVPFLLLAALKCSNSILVRGVFIDAEGVGADSVDIPINYVRLHFLRERRKKAGLQATSQPPPPHYYLKPEHVSIGRNAEKDKEAQSSLIEKPHAAVQIV
Protein: Transmembrane protein 65 (Q38AF3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRIQCCIPGGISHSRRWSQRFHSVEGVPRLSQEELRRLVDILESDPKILGDIIGRLDAASRRRLIVAGGAIEWFGKDNAVTEMKRAGVDKDRFISPKDFDHWLEGALRRRQEEEDEEVTDRLQKQAMDEADELVPYSTLLWVALVAGLPFVGFGFLDNAMMILAGDAIDNSFGLYFNCSVLTCAAMGNIFSGVLGMQLHGVIEKAVQRFNFRVPTLTENQMKGKRVFFAGHIGGTVGIMTGLLLGMIPLLLLDSDDAKNERTAGESLAVAKTN
Protein: Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (TAFII-130) (TAFII-145) (TBP-associated factor 1) (TBP-associated factor 145 kDa) (P46677)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 7
- SAGA complex/transcription factor TFIID complex subunit TAF6
- Transcription initiation factor TFIID subunit 4
- SAGA complex/transcription factor TFIID complex subunit TAF5
- Transcription initiation factor TFIID subunit 8
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 3
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 11
Sequence:
MVKQQGSGKTNLANEDEAYEAIFGGEFGSLEIGSYIGGDEGANSKDYTEHLPDAVDFEDEDELADDDDDLPEESDANLHPAMMTMGAYDDVNENGAVLGIDSNSLNMQLPEINGDLSQQFILEDDGGTPATSNALFMGMDANEIHLATETGVLDGSGANEIGHSQLSIGGVNGNDMSINGGFIMEPDMSDGKHKKATKLDLINHEKYLLKKYFPDFEKGKILKWNKLIYRRSVPYHWHSEISRVKKPFMPLNLKFKVQQDDKRLFNSRTISYVAPIYQGKNNLLQSNSSASRRGLIHVSIDELFPIKEQQKKRKIIHDEKTISEDLLIATDDWDQEKIINQGTSSTATLADSSMTPNLKFSGGYKLKSLIEDVAEDWQWDEDMIIDAKLKESKHAELNMNDEKLLLMIEKTNNLAQQKQQLDSSNLILPLNETILQQKFNLSNDDKYQILKKTHQTKVRSTISNLNIQHSQPAINLQSPFYKVAVPRYQLRHFHRENFGSHIRPGTKIVFSKLKARKRKRDKGKDVKESFSTSQDLTIGDTAPVYLMEYSEQTPVALSKFGMANKLINYYRKANEQDTLRPKLPVGETHVLGVQDKSPFWNFGFVEPGHIVPTLYNNMIRAPVFKHDISGTDFLLTKSSGFGISNRFYLRNINHLFTVGQTFPVEEIPGPNSRKVTSMKATRLKMIIYRILNHNHSKAISIDPIAKHFPDQDYGQNRQKVKEFMKYQRDGPEKGLWRLKDDEKLLDNEAVKSLITPEQISQVESMSQGLQFQEDNEAYNFDSKLKSLEENLLPWNITKNFINSTQMRAMIQIHGVGDPTGCGEGFSFLKTSMKGGFVKSGSPSSNNNSSNKKGTNTHSYNVAQQQKAYDEEIAKTWYTHTKSLSISNPFEEMTNPDEINQTNKHVKTDRDDKKILKIVRKKRDENGIIQRQTIFIRDPRVIQGYIKIKEQDKEDVNKLLEEDTSKINNLEELEKQKKLLQLELANLEKSQQRRAARQNSKRNGGATRTENSVDNGSDLAGVTDGKAARNKGKNTTRRCATCGQIGHIRTNKSCPMYSSKDNPASPK
Protein: SD04373p (Q8MRG2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNSRRIALVLLIGIIVSFSGHDALTYPERFDRLPTWGGHSQIGGPLLDTAHRENREKRENRVDLCRHCFCIHLKAICDYKLNKTLPNEFNDKLLVPLNIKYIEVRLTVGTQFVMYENFFQDNQVNYFGVIGVGKDDQVEITSNAFSHNKGGFPNIEIRNVLRVFLREKFLTGADYKLLVEDVTQLSVFSNALQMTNLDCSLKRIKELNLMKNAFNPGVAKYGINLRIEDSNINQLGIFGVSMGKVSLLRCHIDMIMSNAFDVTSIKELIIEGCNIEVIESQALTNKLHSDKVAIVDTVIGTIEGQAISQSGITTMIMFGNTITKIRSNAIQIVAVSLFIRNNSMSHVEPNWLSVSQADQVEIANNRFEDYGRCELNIGSSNCSFRNNILQNPQSGSLNFTCRVHQVRVGTECSCNKSWLSELTDHDLESEIMCQVAKRDANCFNTTNTDVRRYVNEACGSNVTRYCMGGQWVTKAVSDHSSDSSKLTIGMIALEIVILTLLLVAIVCVLAKNCGSGSCAPAGGQSTDNCLIEEDIRNSLRQLALHSESNKTRKAILKLINGHLSKGECNDRILFIVDNMPQNQAIESLLFRHISQSHMEPSDSEAYASTALTANATAPPLPPSTDSSEPIYQELDQQRLIIDDKYSLPLNSDEDPPYSEPSNMMNTNDMPPAYQYATPMRILPCHQMQHQQPSTTANYAIPVWRSTPSATPTSRPPSGSQEGSATATAPRAVKDLRQALQNSPQFHPNQLTSTRNQRQILQILPPLQPPPYTQRSQVRGQRRRSFECLDGAASLAAMEHMDSGSDHSGGSDVTVQIADVIDYADA
Protein: Wee1-like protein kinase (EC 2.7.10.2) (Wee1-At) (Q8L4H0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cell cycle regulatory kinase that is not rate-limiting for cycle progression under normal growth conditions. Transcriptionally activated upon DNA stress or damage in an ATR- or ATM-dependent manner. Once activated, inhibits plant growth by arresting dividing cells in the G2 phase before proceeding into mitosis. Down-regulates CDKA-1 and CDKD-2 by tyrosine phosphorylation. May target principally CDKA-1.
Subcellular location: Nucleus {ECO:0000269|PubMed:16856985}.
Interaction partners:
- Dual specificity phosphatase Cdc25
- Cyclin-dependent kinase A-1
- Cyclin-B1-1
- Serine/threonine-protein kinase ATR
- Cyclin-B1-2
- Cyclin-A1-1
- Cyclin-A2-3
- Probable inactive protein kinase At3g63330
- SUPPRESSOR OF GAMMA RESPONSE 1
- Cyclin-B1-3
Sequence:
MFEKNGRTLLAKRKTQGTIKTRASKKIRKMEGTLERHSLLQFGQLSKISFENRPSSNVASSAFQGLLDSDSSELRNQLGSADSDANCGEKDFILSQDFFCTPDYITPDNQNLMSGLDISKDHSPCPRSPVKLNTVKSKRCRQESFTGNHSNSTWSSKHRVDEQENDDIDTDEVMGDKLQANQTERTGYVSQAAVALRCRAMPPPCLKNPYVLNQSETATDPFGHQRSKCASFLPVSTSGDGLSRYLTDFHEIRQIGAGHFSRVFKVLKRMDGCLYAVKHSTRKLYLDSERRKAMMEVQALAALGFHENIVGYYSSWFENEQLYIQLELCDHSLSALPKKSSLKVSEREILVIMHQIAKALHFVHEKGIAHLDVKPDNIYIKNGVCKLGDFGCATRLDKSLPVEEGDARYMPQEILNEDYEHLDKVDIFSLGVTVYELIKGSPLTESRNQSLNIKEGKLPLLPGHSLQLQQLLKTMMDRDPKRRPSARELLDHPMFDRIRG
Protein: Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) (Q86U86)
Organism: Homo sapiens (Human)
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.
Subcellular location: Nucleus {ECO:0000269|PubMed:25593309, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Interaction partners:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- SWI/SNF complex subunit SMARCC1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- AT-rich interactive domain-containing protein 1A
- Actin-like protein 6A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- PHD finger protein 10
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- Bromodomain-containing protein 7
- AT-rich interactive domain-containing protein 2
Sequence:
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPAYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQAYNLENV
Protein: Scytalone dehydratase-like protein mdpB (EC 4.2.1.-) (Monodictyphenone synthesis protein B) (C8VQ71)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Scytalone dehydratase-like protein; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH that catalyzes the oxidation of emodinanthrone to emodin (By similarity). Emodin is further modified to yield monodictyphenone via several steps involving mdpB, mdpC mdpJ, mdpK and mdpL. These enzymes with xptA, xptB and xptC are also proposed to be involved in the synthesis of shamixanthone from emodin. Especially, direct reduction of emodin by the short chain dehydrogenase mdpC followed by dehydration catalyzed by the scytalone dehydratase-like protein mdpB gives loss of oxygen and formation of chrysophanol intermediate in two simple steps.
Interaction partners:
- Short chain dehydrogenase mdpC
Sequence:
MTLQPTFEGRTPEQCLNVHTDSHPDITGCQAALFEWAESYDSKDWDRLKQCIAPFLRIDYRAFLDKLWEKMPAEEFVAMVSHPHFLGNPLLKTQHFVGTMKWEKVDDSKIVGYHQMRVAHQKHLDSQMKEVVAKGHGHGSATVTYRKINGEWKFAGIEPNIRWTEFGGEGIFGPPEKEENGVAADDQVMNSNGSSEVEERNGHVVNKAVEVRSV
Protein: MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) (P22670)
Organism: Homo sapiens (Human)
Function: Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.
Subcellular location: Nucleus.
Interaction partners:
- Cyclic AMP-responsive element-binding protein 1
- Regulatory factor X-associated protein
- MHC class II transactivator
- DNA-binding protein RFXANK
- Histone deacetylase 1
- Serine/threonine-protein kinase ATR
- Histone-lysine N-methyltransferase SUV39H1
- Large ribosomal subunit protein eL30
- Forkhead box protein J1
- DNA
Sequence:
MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQSPQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEASPGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQALPTQRLVVQSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQEVQQLQQVPVPHVYSSQVQYVEGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSTSTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLEPPAKLARTDARGLFVQALPSS
Protein: Sperm antigen with calponin homology and coiled-coil domains 1 (J3KRB9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLNKPGSTAASGVVRLKKTATAGAISELTESRLRSGTGQARWLMPVIPALWEAEVGGSRGQEMETILTNTVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREYGGSKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET
Protein: m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc) (Q8IU60)
Organism: Homo sapiens (Human)
Function: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:15067023, ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:20616046}. Nucleus {ECO:0000269|PubMed:15273322}. Note=Predominantly cytoplasmic, in processing bodies (PB) (PubMed:15273322). A minor amount is nuclear (PubMed:15273322). {ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:20616046}.
Interaction partners:
- mRNA-decapping enzyme 1B
- mRNA-decapping enzyme 1A
- Enhancer of mRNA-decapping protein 3
- Protein PAT1 homolog 1
- Probable ATP-dependent RNA helicase DDX6
- Enhancer of mRNA-decapping protein 4
- 5'-3' exoribonuclease 1
- CCR4-NOT transcription complex subunit 7
- U6 snRNA-associated Sm-like protein LSm1
- Regulator of nonsense transcripts 1
Sequence:
METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSTGSTPAKPTVEKLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKPYNNHSEMSDLLKGKNQSMRGNGRKQYQDSPNQKKRTNGLQPAKQQNSLMKCEKKLHPRKLQDNFETDAVYDLPSSSEDQLLEHAEGQPVACNGHCKFPFSSRAFLSFKFDHNAIMKILDL
Protein: Polyketide synthase/nonribosomal peptide synthetase hybrid RzxA (Q4KCD0)
Organism: Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- AMP-binding enzyme
- [acyl-carrier-protein] S-malonyltransferase
- Non-ribosomal peptide synthetase PvdJ
- Non-ribosomal peptide synthetase OfaA
- Non-ribosomal peptide synthetase OfaB
- L-cysteine--[L-cysteinyl-carrier protein] ligase
- Non-ribosomal peptide synthetase PvdL
- Non-ribosomal peptide synthetase OfaC
- L-cysteine--[L-cysteinyl-carrier protein] ligase
- NADH-quinone oxidoreductase subunit C/D
Sequence:
MRGARARRGVDQAGQERAKHRRLFVTALANGRLVMERTMNASFTDQLFVIASVLSLESRQLISRQAINQPFDFAPFVAAAAVNPGPLRVTFDGLKAFGWLSQPSAEQYFFNGRASAIGALPAQVIELFSWLAPQRLPHGDDLPSLRRWLALSALDWNLHCPGFVHGLNQLLSLVLLRRLQLHGAIDLDSGRVDLRRIDHEPVDPDGIRLLSDFLRRQQWIRRQERHLVLNPQHRACLAERLSEPFLAYYASLPAILEDLLFSQGQPWAEVLQWLKGAGELQIWPGDRPALERLLGEIFDAQPLSSQPDWIVGFGRHPGVCLSELWQWLRQHSARGQVLDSQPLRWLVLEDGLTGDPQSLRQRLRDAGVAATDRVMWLAIGQQNLQPLEALSTPQLPLPAQRYYLGFDGSAVPGATVLGNLQHSAKALAALIGDQPLVLSERHWRPDGPVADHFACYYPVEAAQYLMALAGAGLFADPGMLHTQLQEGVDCVASSGCYRARDYQVRHVTLADMPALLTLEHACWPEGGRVDEAILRRRLSQDPAGQLALEFRGELVGVIYSQRIAHSDGLFRVDFASVDQLFHGKGSTVQIQSLNILPAHQYSGYGDQLLEFMLQYCTLRHGVDTVVGVTRCKDYPKYRHLALADYIHSRDARGELLDPVLRFHELHGAGIERLVAGYRPADADNDGHGVLVRYDLARRQPQKAAALTAMAAQPTIAIDDAVRQSINHCLGHARDSRVSPRHSLMELGLDSADLLGLSEQLGMTLGLPLEPSFFFRHNNVETIIAALQERRAPQGPSPIDTQAAPGETEPPTPAGMDPDFAVIGISGVFPGGELQGFWGAIRNSLGQIRPVPGERAMAGPVAGYIDGIECFDHGFFAVSAAEAALMDPQQRLLLQHAWLALEDAAIAAPDFARHPTGVFVAAAPSEYREVVELPRASPFLLTSSSPCMYANRISWFLDLRGPSEYCNTACSSVLVALHRAMQAIRAGECRQALVGAVNLLLSPDETAGYRQMGFLSEQAQTRSFQAGADGYVRSEGVGVLLLKPLADALRDGDRIHLKIKGSGVGHGGRGLSLTAPDHDGLQAAMVAAYRSAGVTPDSVSYVEAHGTGSAMGDAIEVDAIQAARRQLSAGRQAGTPWNISTLKPLIGHCELASGMAALFKVIDAVQQRYLPGIPGLQQLGPAIRLDPQQLSLAPENRPWPALKDGQGQALPRRASINSYGFGGVSAHLVVEEFIAQPRQTPAATGLQLILLSAQDAQRLREQAGRLSQAIGQLAPVCLADIAYTLQVGRTAMACRWTCLVDSVAALQQQLSELAQGLRDDLVQVDEQASAVDGAQAQALAQPDWPALAEYWRQGGTLDWHSLARQGQPRRIGLPGYPFARQRHWLAPRRIATHQPADPGTAPPANSLRQVLAQVLGCDPQSLAGCESRSLASLGLNSLGAVGLKARLEQQLHVSLCLAQLSPYLSLAEVEANLAAREPHADAQAGPVLQPAPDAAHQPFALNDIQQSFLSGRTLLAEAERVGCHIYLEFDWPELDVYRLNQAWNRLLLQHDALRLRVLDDGRQQVGEAKPYGFNIRDLRRCDPQDRERSLAALRGSMSHKVYLAGDDRLFEVAVSLLDRQHSRVHLSIDEWIVDATSLEVLLQQWLMWYREPDATLADQGVSLRDYQRALESCKDSPHYRRDLQYWLDKLAAAPPGLYLPKAPRPAGRQRQRLTSTLEPSRWQRLKERGTALQVSGTALLLSLFGLILQRANAGQAFSLITTSYGRLPLHPDIERLVGPLISTQFFAFAAAREQSLGEWVQGVQRQLLEDLDHASVGGVAALREIRRRGEPSQPFKGGEVVFTSMLNNPLLDAAPSFGDAQHYCVTQTPQINLDHQLRERGGALSLSWDVAIDCYPDGLIEQLFTDYCQLLCRLADADDHWQALKSTDLLPMAPFQLASSAEPTQPFALTDQQQAYAFSRSLHPGQGGAQLYLALSIPALDVARLARAWQQLQAHHPLLRTRVLANGTQQIMQIPPGGQLETLGQGVSPAQVAEELLGRVTALGDWPYAVLKVSSATAGQSLVHLAVDLLLVDLPSRDLLIRQLLKLYLGATLPPLTIHFADYIAALGQHKRTPAAQDAALYWQEKFRRLPQGPQLNANRDVNGLYLKYEHRLDCWPLLCKRIEHAGISADALLISVYAFCLAKHCALPAFTLVAPGWKRPPVHPQIDALVGDFTTLSWIDFNSQAPTFIEQARRCDRIFTEDQQHSAISGLQALRKVATDKQHPRTLDFPVVFTRLNPQGSLDLPEGVTLVDSASRTHGVALDNLSIETPGALLIHWDLASDRLTAAQGEAMFGEYCRLLERLAVEEGEWGMDGL
Protein: Zinc finger protein 69 homolog B (Zinc finger protein 643) (Q9UJL9)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation. Essential for Golgi structural integrity.
Subcellular location: Nucleus {ECO:0000269|PubMed:29851555}.
Interaction partners:
Sequence:
MLQQLLITLPTEASTWVKLRHPKAATERVALWEDVTKMFKAEALLSQDADETQGESLESRVTLGSLTAESQELLTFKDVSVDFTQEEWGQLAPAHRNLYREVMLENYGNLVSVGCQLSKPGVISQLEKGEEPWLMERDISGVPSSDLKSKTKTKESALQNDISWEELHCGLMMERFTKGSSMYSTLGRISKCNKLESQQENQRMGKGQIPLMCKKTFTQERGQESNRFEKRINVKSEVMPGPIGLPRKRDRKYDTPGKRSRYNIDLVNHSRSYTKMKTFECNICEKIFKQLIHLTEHMRIHTGEKPFRCKECGKAFSQSSSLIPHQRIHTGEKPYECKECGKTFRHPSSLTQHVRIHTGEKPYECRVCEKAFSQSIGLIQHLRTHVREKPFTCKDCGKAFFQIRHLRQHEIIHTGVKPYICNVCSKTFSHSTYLTQHQRTHTGERPYKCKECGKAFSQRIHLSIHQRVHTGVKPYECSHCGKAFRHDSSFAKHQRIHTGEKPYDCNECGKAFSCSSSLIRHCKTHLRNTFSNVV
Protein: Zinc-finger homeodomain protein 2 (AtZHD2) (Homeobox protein 22) (AtHB-22) (Protein MATERNAL EFFECT EMBRYO ARREST 68) (Q9SB61)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein. Putative transcription factor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable calcium-binding protein CML14
- Homeobox-leucine zipper protein ATHB-21
- F3H9.20 protein
- Vacuolar protein sorting-associated protein
Sequence:
MNFEDQEEDMEMSGVNPPCGYDSLSGEGATSSGGGGVGRSKGVGAKIRYRECLKNHAVNIGGHAVDGCCEFMPSGEDGTLDALKCAACGCHRNFHRKETESIGGRAHRVPTYYNRPPQPHQPPGYLHLTSPAAPYRPPAASGDEEDTSNPSSSGGTTKRFRTKFTAEQKEKMLAFAERLGWRIQKHDDVAVEQFCAETGVRRQVLKIWMHNNKNSLGKKP
Protein: Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) (P30548)
Organism: Mus musculus (Mouse)
Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Protachykinin-1
- Tachykinin-4
- Tachykinin-3
- Beta-arrestin-2
- Beta-arrestin-1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Transient receptor potential cation channel subfamily V member 1
- Neprilysin
Sequence:
MDNVLPVDSDLFPNTSTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEDEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
Protein: Four and a half LIM domains 1b (Four and a half LIM domains protein 1b isoform X1) (F1Q7A2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Recombination signal-binding protein for immunoglobulin kappa J region a.
- Recombination signal-binding protein for immunoglobulin kappa J region b
Sequence:
MASRSNCFYCREDLSGKKFVRKDEKQVCVRCFDKFCANTCTECRRTISTDSKELHHKGKYWHSDCFRCAKCYKNLAKESFTSKDDRILCGTCSSREDAPRCHGCYKPILPGTENVEYKGNSWHDECFKCYQCQKPIGNKSFITKNNNVYCSPCHEMKFAKQCACCKKPITTGGVNYQDQPWHSECFVCSSCRKPLAGTRFTSHEEKVYCVDCYKSTVAKKCSGCQNPITGFGKATNVVNYEGGSWHDYCFNCKKCSLNLADKRFVAHSGHIYCSDCSKKL
Protein: Ring-exported protein 4 (Q8I2F6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MGNFFIISYNKHCIGQIIHMLYFICLIFILYNRNTCLRRIAKCGRNLSELNLDLRTDYDEREININKNIPSYPVKFSKLEYKLRNEWDELEIDEHDDYMDVTVECFEKLLENDKNLENYQENYEIRALVAYMLHELRRGYINEQKMKFKNFLHKLKEKRINEPIDTLNNDEQDEWNKIKNGKIKSDEEWKSYQLQTWEYLIKMEYYKNKYSQNV