wanglab/gogpt-training-data huggingface dataset:
Protein: diguanylate cyclase (EC 2.7.7.65) (Q9HZX6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- cyclic-guanylate-specific phosphodiesterase
- Cyclic di-GMP phosphodiesterase RocR
- cyclic-guanylate-specific phosphodiesterase
- EAL domain-containing protein
- GGDEF domain-containing protein
- Cyclic di-GMP phosphodiesterase PA2567
- Probable two-component response regulator
- cyclic-guanylate-specific phosphodiesterase
- Oxidoreductase molybdopterin-binding domain-containing protein
Sequence:
MTVPLLDPTKLRRQRQIMGLLLGLVLLMALIAGAALWLAVRQAQQLAQPNLHNELWQTYSLRAELDRTLDAARHTESGEGQADDLAIRLEVLASLIAPLRRQSLFRHLAEPRPEVQATLQRLIELSDRWSDQAPWGDPVAARRLAAEIVQQVPPLLEPTHQIVVASNIALTNQLDVDRKRLHRAFYALFWALLGIGAGGALLVLRLVADFKRAQQLAGHLIELNATLEKRVGERTRQLSEGKALLHFILEASPSDVVLLSACGASIHYVSPRLLKRLGCQAQDDFNLPRLFASASEYSRLQNALEARGQVDGWEAQLCGETPCWAVICARHLEIDGEPATLIWCYDISRRKAMEQELRLLASTDTLTGLHNRHSFLHQAELMLKAAERFRHPCVALMLDIDHFKNINDSHGHLTGDRALQRVAETLRQGLREVDLLGRLGGEEFAALLPEVSLDQALDVAERLRAGVEALRVSNPDGEPLRMTVSIGVALRRDAGDDLESLLVRADSALYQAKSGGRNRTEYAPA
Protein: Glutathione hydrolase 1 (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (EC 2.3.2.2) (Q8VYW6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in preventing oxidative stress by metabolizing extracellular oxidized glutathione (GSSG).
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:17316175}. Note=Associated with the plasma membrane and cell wall.
Interaction partners:
- Glutathione synthetase, chloroplastic
- 5-oxoprolinase 1
- Puromycin-sensitive aminopeptidase
- Gamma-glutamylcyclotransferase 2-2
- Gamma-glutamylcyclotransferase 2-3
- Leucine aminopeptidase 1
- Glutamate--cysteine ligase, chloroplastic
- 1-Cys peroxiredoxin PER1
- Glutathione reductase, cytosolic
- Leucine aminopeptidase 3, chloroplastic
Sequence:
MSLVRTVTIVLFIIAFLQNAAAQKRQQSIVKSRGAVATDDGRCSVIGMRVLREGGNAIDASVAAALCLGVVSPASSGIGGGAFTVVKIAGGKEIAYDSRETAPLRATENMYGGNVDLKKKGALSVGVPGEVAGLFTAWKQHGKLPWKRLVTPAEKLAEGFKISKYLYMQMNATRSDILADKGLSDLFVSNGELKKPGTICHNPKLALTLKLIGEYGPKAFYNGTVGVNLARDIKKSGGIITLKDLQSYRVKIKEPLSADILGYRVLGMPPPSSGGAAMMLVLNILSQYGIPSGVSGPLGVHRLIEALKHAFAVRMNLGDPDFTDVTKVVSDMLSPKFAKDLKSKINDQKTFDPKYYGGMWNQIDDHGTSHLSIIDRERNAVSMTSTINGYFGALMLSPSTGIVLNNEMDDFSIPMKSNGNLDVPPPAPANFIRPGKRPLSSMSPTIVLKDGKVKAAVGASGGANIIAGTTEVYLNHFFLKMDPLSSVLAPRIYHQLIPNRASYENWTTVFNDHFEIPKATRVVLEKKGHVLSPIAGGTIAQFIVQESGENSGGRSELVAVSDPRKGGFPSGY
Protein: Taurine-binding periplasmic protein (Sulfate starvation-induced protein 1) (SSI1) (Q47537)
Organism: Escherichia coli (strain K12)
Function: Part of a binding-protein-dependent transport system for taurine.
Subcellular location: Periplasm {ECO:0000305}.
Interaction partners:
- Taurine import ATP-binding protein TauB
- Alpha-ketoglutarate-dependent taurine dioxygenase
- Taurine transport system permease protein TauC
- Putative aliphatic sulfonates transport permease protein SsuC
- Alkanesulfonate monooxygenase
- Putative aliphatic sulfonates-binding protein
- Aliphatic sulfonates import ATP-binding protein SsuB
- Sulfate-binding protein
- Sulfate transport system permease protein CysW
Sequence:
MAISSRNTLLAALAFIAFQAQAVNVTVAYQTSAEPAKVAQADNTFAKESGATVDWRKFDSGASIVRALASGDVQIGNLGSSPLAVAASQQVPIEVFLLASKLGNSEALVVKKTISKPEDLIGKRIAVPFISTTHYSLLAALKHWGIKPGQVEIVNLQPPAIIAAWQRGDIDGAYVWAPAVNALEKDGKVLTDSEQVGQWGAPTLDVWVVRKDFAEKHPEVVKAFAKSAIDAQQPYIANPDVWLKQPENISKLARLSGVPEGDVPGLVKGNTYLTPQQQTAELTGPVNKAIIDTAQFLKEQGKVPAVANDYSQYVTSRFVQ
Protein: Death-associated protein kinase related (EC 2.7.11.1) (Q0KHT7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Myosin regulatory light chain sqh
Sequence:
MFTEKGIFPIGDGLLDVDADRLKGLLVSCPDINEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWLKDDCSLDRQIYLQPQSDAEEEEEEDVDDDVEDEEEEEQVEEEEEETQNVEEPTTEAPQQQQQPVQQHQLAKSGQIHSKPTHNGHHRANSGGSISKIPIATSKLQSTPSSETTTAIHTLTSNSNGHVHKPTQIVTPTRRASDSDKENTYTATFVKKPVATIQLGSSNGIEDATVVATLTLFPDAPTTPKVIRKTPTGESNGSATSVKALVKKFQLEDSSGSAVARRSGGAVTSSSGLHSPTTTSVRLNSIRRASEPLTTVYKKQTSQNGCSSTSNPSSSPGSSPTTSGSTATLLIHSQRLGNSTAPASHCVAVPATATATSSASSSNSSSGKSTSAAHHLHHHHMHHHHHHHHHHVVIAAKNAAAVAATNNLSLDQGIIC
Protein: Peroxisome biogenesis factor 10 (EC 2.3.2.27) (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (Q05568)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase. When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:12876220, ECO:0000269|PubMed:27678487, ECO:0000269|PubMed:35768507}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisomal targeting signal receptor
- Peroxisomal membrane protein PEX14
- Peroxisomal biogenesis factor 8
- Peroxisomal membrane protein PEX13
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX17
- Peroxisomal membrane protein import receptor PEX19
- Peroxisomal biogenesis factor 2
- Peroxisomal membrane protein PMP27
- Peroxisomal targeting signal 2 receptor
Sequence:
MKNDNKLQKEALMRLSQLRFPFADAPSIVQAHQKDEQIQGLLIMKVTELCKLIKSQLFVNSYPKELSIFAKLLYLLFTTGRRGRTLGEEYVDLTYTNRKGTRLAGRLKMIVFAFAYPLCPYFITKLYKKIMKNNKESKIEDTESVAAFCKGLLDFILDVHMTLFYFKGAFYSISKRIFGMRYVFKHILSKNEANFREEGSQKYKVLGYILLAQNVMKWYPVLTSTLGSWIYGRKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMSDPSCAPCGHLFCWSCLMSWCKERPECPLCRQHCQPQEILVLRQ
Protein: Auxin response factor (F4HT52)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004561}.
Interaction partners:
Sequence:
MENNGEMNAQPELSVDITKTYMYEKLWNICAGPLCVLPKPGEKVYYFPQGHIELIENSTRDELDHIRPIFDLPSKLRCRVVAIDRKVDKNTDEVYAQISLMPDTTEVMTHNTTMDTRRPIVYFFSKILTASDVSLSGGLIIPKQYAIECFPPLDMSQPISTQNLVAKDLYGQEWSFKHVFRGTPQRHMFTSGGGWSVFATTKRLIVGDIFVLLRGENGELRFGIRRAKHQQGHIPSSVISANCMQHGVIASVVNAFKTKCMFNVVYKPRMQFEGKDFSEKRYDGTIIGVNDMSPHWKDSEWRSLKVQWDELSPFLRPNQVSPWDIEHLIPSSDISQSSLKKKKHWLQLNEIGATLSNLWTCQEIGQRSMNSPISVPEFSYPNAIEDSKFLSGLLLNHSLLAIPNENYNSDQMIQPRKEDITTEATTSCLLFGVDLTKVHMQGVAISRAVDLTAMHGYNQLIQKLEELFDLKDELRTRNQWEIVFTNNEGAEMLVGDDPWPEFCNMAKRIFICSKEEIKKMKLKNKFFQPESKALTSSDVPPNVTDN
Protein: Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: Brain natriuretic peptide 45 (5 kDa cardiac natriuretic peptide) (BNP(77-121)) (Brain natriuretic peptide) (BNP)] (P40753)
Organism: Mus musculus (Mouse)
Function: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Likely involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis (By similarity).
Subcellular location: [Brain natriuretic peptide 45]: Secreted {ECO:0000269|PubMed:8182124}. Note=Detected in blood. {ECO:0000269|PubMed:8182124}.
Interaction partners:
- Atrial natriuretic peptide receptor 1
- Atrial natriuretic peptide receptor 3
- Natriuretic peptides A
- Atrial natriuretic peptide receptor 2
- C-type natriuretic peptide
- Myosin-7
- Myosin-6
- Troponin I, cardiac muscle
- Troponin T, cardiac muscle
- Angiotensinogen
Sequence:
MDLLKVLSQMILFLLFLYLSPLGGHSYPLGSPSQSPEQFKMQKLLELIREKSEEMAQRQLLKDQGLTKEHPKRVLRSQGSTLRVQQRPQNSKVTHISSCFGHKIDRIGSVSRLGCNALKLL
Protein: ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) (P41970)
Organism: Homo sapiens (Human)
Function: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
Subcellular location: Nucleus.
Interaction partners:
- Voltage-gated delayed rectifier potassium channel KCNH8
Sequence:
MESAITLWQFLLQLLLDQKHEHLICWTSNDGEFKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDKNIIKKVIGQKFVYKFVSFPEILKMDPHAVEISRESLLLQDSDCKASPEGREAHKHGLAALRSTSRNEYIHSGLYSSFTINSLQNPPDAFKAIKTEKLEEPPEDSPPVEEVRTVIRFVTNKTDKHVTRPVVSLPSTSEAAAASAFLASSVSAKISSLMLPNAASISSASPFSSRSPSLSPNSPLPSEHRSLFLEAACHDSDSLEPLNLSSGSKTKSPSLPPKAKKPKGLEISAPPLVLSGTDIGSIALNSPALPSGSLTPAFFTAQTPNGLLLTPSPLLSSIHFWSSLSPVAPLSPARLQGPSTLFQFPTLLNGHMPVPIPSLDRAASPVLLSSNSQKS
Protein: NAD(P)-binding Rossmann-fold superfamily protein (F4JRN8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT3g19540/T31J18_4
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 beta subcomplex subunit 7
- At1g72040
Sequence:
MEVSSSLKLSSSLSPSIIKLQGSSSSIDIKFSKYTSLPKPFLQLDDKSRRLRDQQVSHSLELRSYRKRVTAKSGSQGWDFGRFVKTLYFFNGPPSPLKFVSSVFEKLTNGATEEPVAEMGTSGIILVAGATGGVGRRIVDILRKRGLPVKALVRNEEKARKMLGPEIDLIVADITKENTLVPEKFKGVRKVINAVSVIVGPKEGDTPERQKYNQGVRFFEPEIKGDSPELVEYIGMKNLINAVRDGVGLENGKLIFGVGDNTFKDLPWGALDDVVMGGVSESNFIVDLTAGENGGPTGIFKGIVSTTNNGGFTSVRTKNFPEAENVSAYDGLELRLKGDGLRYKLIVRTSQDWDTVGYTASFDTSPGQWQSVRLPFSSLRPVFRARTVTDAPPFNASSIISLQLMFSKFEYDGKLNPTFKEGPFELPLSSIRAYIQDPVTPRFVHVGSAGVTRPERPGLDLSKQPPAVRLNKELDFILTYKLKGEDLIRDSGIPFAIVRPCALTEEPAGADLIFEQGDNITGKVSRDEVARICIAALESPYALNKTFEVKSTVPFSEPFTVDPENPPPEKDYNEYFKTLKDGITGKEALEQSTVAKSSPLKRWRPDTACLVIKLKLRHVNVLLKKFV
Protein: Protein lifeguard 1 (Glutamate [NMDA] receptor-associated protein 1) (NMDA receptor glutamate-binding subunit) (Putative MAPK-activating protein PM02) (Transmembrane BAX inhibitor motif-containing protein 3) (Q7Z429)
Organism: Homo sapiens (Human)
Function: Potential apoptotic regulator.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Bax inhibitor 1
Sequence:
MSHEKSFLVSGDNYPPPNPGYPGGPQPPMPPYAQPPYPGAPYPQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQVFPGQDPDSPQHGNYQEEGPPSYYDNQDFPATNWDDKSIRQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYASLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGRAKE
Protein: Germacrene D synthase 1 (EC 4.2.3.75) (PatTpsB15) (Q49SP4)
Organism: Pogostemon cablin (Patchouli) (Mentha cablin)
Function: Sesquiterpene synthase involved in germacrene D biosynthesis. Produces also at least 13 additional sesquiterpene products, including germacrene C and (+)-germacrene A, beta-ylangene, (E)-beta-farnesene and (E,E)-alpha-farnesene.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}.
Interaction partners:
Sequence:
MDLNEITSSSRPLANYHPNVWGDRFLLHEPEFTCQAGEKQLVEELKEEVRRELKEASNDYLRQLKMVDAIQRLGIEYLFEEEIDEALRNLLAKFENYCKDNHDMYATALSFRLLRQHGYKVSCEVFDKFKDGEDGFKVEEVMAVLELFEATHMRIHGEDVLDQAFVFTRNYLQSIHATLSNPIAKQVHNALNGYSCRRGMPRIEARKYIPIYEEYGCHHKALLKLAKLDFNLLQSMHKRELTQLYRWWKDLEMPTKLPYIRDRLVETYFWDMGFYFEPQYALARNILVKVQCLVSIFDDTFDAYGAFKELQLFKDAIDRWSISCLDELPEYMQIIYKLVLDVFEEIESHMIKQGTSYRLDYAREAIKIVIGGYFDEAKWREEEYKPRMEEYMKVATKSAAYLTLIIVSFVGMKNDIATPQAFQWVLSEPQIITASLALARLSNDLVGIEFEKERKYIATAVELYEEEHKVSKEEAVLELRHETESAWKEINEALLEPTTFATPILDRILNSARVLEVFYDKTDRYTHVDLELQNIIAQLYIHPIP
Protein: Kinetochore protein Nuf2 homolog (CeNuf2) (Kinetochore protein him-10) (Protein high incidence of males 10) (Q21952)
Organism: Caenorhabditis elegans
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolymerizing microtubules.
Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores.
Interaction partners:
- Kinetochore protein ndc-80
- Kinetochore-binding protein 3
- Calponin-homology
- Kinesin-like protein
- Mitotic spindle assembly checkpoint protein MAD2A
- KNL
- Zygote defective protein 9
- Aurora/IPL1-related protein kinase 2
- Kinesin-like protein
- Histone H3-like centromeric protein hcp-3
Sequence:
MSNVVLIVYDPRMISKYLGQKLHMGLVADDIIKPTAEIAQQIFANFVRLVLNVSESSLTTLPLSANCDYDPELHKKSIPIIILFQCMKAFIKDNSGNKLDLTMCDLVTPAKHEHRFRKLTSFLVDFLKLHELATPAFNEISEEFSDRKFEMEKIREELLEAEKKKNDLLAKQSIRKRHEHELINEQSNAKAELKNVVNEYTETRQINEELDKQKEEAILHIQALEKEMLTGKKTIEHLNEEVLTSPEQLKQEMEERKRHIEELRDCLESSKKGLQAKLEAREICINSEKNVPVIIEKIHQWTEVREVIIDLIDVESENLRKLKEMEEQLDFMMKEMETAQKRLVEQSETHEQLRIEHTQKSEERQRRIEEITEQIANLKTSQPDVSQEIAKKKQELLALKNAHSETISQITNSCQDAVAKFAKLNAMFKETQKVAFEKNTAAAREMERLKSSLTGRLLSDYTFGSSTIDAGENTENCDPQPNDSSFSVFK
Protein: Always early (Q2PNP8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRHQLKKPRKMVAAWQNDELFIKRPNFAPRIRISEKPEIQGRVKPGVASKRIENFTKKPSKISVDVSEDEKAKEKEKEQDPYSNDFILGKRLYNFLKYLSSHRWIWCEFVDSFLDKPTLTMGYDMKRFIAEYCPLLHSCFMPRRGWQLVRRNMGKARRFSAAFIELEREELECQRRIVRQLQQHKFNPKENVGYLDQIPKRVPLPLAKDATVSSFLHGNSFEGIVNGTVMGYDPQDYTYLVRFNRNDNAVVLSLPDSQLYSDEETAAVPLSIIMRGNKSSSVISESAKTEKFGNKRYTKELLESMLRVGKLQDVKHKILMDLARMNEDFETFKEIGSSSSRRDAKVTPQRENLQRRYSASMITLHRVNADILEPLCILHDYXVEYQKQDEEEESKRGRPASEVYQKCRMQAEQDLKTAADEKFLKIESDRTQEFVRNLHTILYLNGKLGRENSSNLETIIADLVTHMVDNIQPSLGRKLKDGVDSLEPLRQQVVQIFKDVKKPERFQITQQAPMQTEDGIYNFVVEAQPDTPS
Protein: NPL4 homolog, ubiquitin recognition factor S homeolog (Npl4 protein) (Q7SZT9)
Organism: Xenopus laevis (African clawed frog)
Interaction partners:
- Ubiquitin recognition factor in ER-associated degradation protein 1
- Ubiquitin recognition factor in ER-associated degradation protein 1
- UBX domain-containing protein 7 isoform X1
- UBX domain-containing protein.
- Uncharacterized protein.
- Uncharacterized protein
- UBX domain-containing protein.
- Fas
- Fanconi_A_N domain-containing protein.
- RING-type domain-containing protein.
Sequence:
MSESIIIRIQSPDGIKRINASKRETAATFLKKVAKEFGFRNNGFSVYVNRNRTGEISASQNKSLHFLKIKHGDMLFLFPSSSAGPSTEVMDISAAVPGSRPISSPQVVDDEIDQYLSKQDGKIYRNRDPQLCRHGPMGKCVHCVPLEPFDEDYLNHLDPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHPPWPEGICTKCQPSAITLNRQKYRHVDNIMFENHTIADRFLDFWRKTGNQRIGYLYGRYTEHKDIPLGLRAEVAAIYEPPQIGTQNSLQLLDDPKAKVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSAEECITAGYFQNKYPNLCRLSPDAHFGSKFVTVVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCRDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSTSSNLFPIENRDVLGETQDFHSLATYLSQNLSSVFLEIISDFHLLLFLVTNDVMSLQDSISLLLDAVRTRNEELAQTWKKSEQWATIEQLCSTVGLQPSELHDYGAIGGASHAASSSMWSCVHCTFMNQAGTDHCEMCRLPHT
Protein: Microtubule-associated protein RP/EB family member 1 (DdEB1) (Q8WQ86)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes.
Subcellular location: Cell projection {ECO:0000269|PubMed:12134070}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12134070}. Cytoplasm {ECO:0000269|PubMed:12134070}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12134070}. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.
Interaction partners:
- Tubulin alpha chain
- Kinesin-related protein 2
- Centrosomal protein 224
- Aurora kinase
- Tubulin alpha chain
- TOG domain-containing protein
- Tubulin beta chain
- Uncharacterized protein
- Lissencephaly-1 homolog
- CLIP-associating protein
Sequence:
MEGFGRNEILNWINDLLQLDYKKIEQLGSGAALCQLVDIIHPGKINLKMVNFNAKYDYEYIKNFSYLQESFAKLGVEKYVEVSELVKSRPQANLEFAQWMKKYFDQYYTGEPYNAIERRIALKIPTDKDRSSLKGKTAATGAPPTSKPSPSSTLKPATTAASKPAPVSKPTTTTAKPTPSSVSKPVSKPTPSSISKPVSKPTPSISKPVTKPTPTTTSTSTTTTVSTPPSTPKPTNTPIPSTTGKPTLTQPTFKPTPKSVSPTPPVVAGSTVTTKTVIVSEPPTELLEELEQQKRELEQQRKELEEQKSVIQEMTEKIANFEITIQDIEKDRDFYFERLREAEIFCQDHSDVPLLGEVLKILYNSNGEEEGEEGEGEEQGGEEEEEEEEQGENNIEQEEEEQIEQQQQQQEEEEEHERETLSEPEPDQDNSAIPLEQLEINDEEEEFNQHQEQEEEDEHFEDEEKVNGLNEEEIMNSVLQNASDEDDILESTFDGNEDDSLLQDEY
Protein: Acetylcholine receptor subunit beta (P11230)
Organism: Homo sapiens (Human)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Interaction partners:
- 43 kDa receptor-associated protein of the synapse
- Acetylcholine receptor subunit alpha
- Acetylcholine receptor subunit delta
- Acetylcholine receptor subunit epsilon
- Neuronal acetylcholine receptor subunit alpha-9
- Acetylcholinesterase collagenic tail peptide
- Muscle, skeletal receptor tyrosine-protein kinase
- Neuronal acetylcholine receptor subunit alpha-2
- Protein Dok-7
- Neuronal acetylcholine receptor subunit beta-3
Sequence:
MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATYHLPPPDPFP
Protein: DNA double-strand break repair Rad50 ATPase (pfRad50) (P58301)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. The ATP-bound conformation promotes DNA end binding and end tethering, and alters Mre11 nuclease activity. ATP hydrolysis promotes both Mre11 activity as well as HerA/NurA activity. Has also reversible adenylate kinase activity.
Interaction partners:
- DNA double-strand break repair protein Mre11
- Flap endonuclease 1
- DNA double-strand break repair nuclease NurA
- DNA double-strand break repair helicase HerA
- DNA topoisomerase 1
- RNase l inhibitor
- Replication factor A related protein
- DNA ligase
- Metal-binding protein
- DNA polymerase
Sequence:
MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGTKYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAISAFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREVLNLDKFETAYKKLSELKKTINNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLEETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDAYLALKEFKNEYLDKKYKIEKELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKLAILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLEELETKKTTIEEERNEITQRIGELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDRKSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTLEGRIRGLAEDLKKLAPLEKKLAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLRELEEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAEVEADIERIEKKLSQLKQKYNEEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLEKAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIALGLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEVVS
Protein: Apoptosis and caspase activation inhibitor, isoform A (Apoptosis and caspase activation inhibitor, isoform B) (RE13534p) (Q9VYK8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Apoptosome protein Dark
Sequence:
MSGKDDRSKEKRRNMKQYNHHHKKDQGRSTTSSGSPPPTSRRSMVDVADSSDEPRLARRGNWQSSGAGRSSLAPQRNRDMLDTLPSDTDDVEQLGLDGAPIDENARAQLRAGDFQQLAQFPSLGGGHFTFGSEREWANVAEGQTKLHTKAASAYFTLNLTRLNVGLQTIPLYKRMDYPASLFTRAQIAAQEKAAERAEAVYQQCILKDANGGAKSRAPSAKSNKDVAPAAAEKPIAASAAEPDELDELLAMTDTQLDIGSGTITMPMPMVQPATPSSAASKNGVEEWLDSVLDE
Protein: Bifunctional levopimaradiene synthase, chloroplastic (Abietadiene synthase) (EC 4.2.3.18) (Levopimaradiene synthase) (EC 4.2.3.32) (Terpene synthase TPS-LAS) (PsTPS-LAS) (PsTPS-LASl) (F2XFB2)
Organism: Picea sitchensis (Sitka spruce) (Pinus sitchensis)
Function: Terpene synthase (di-TPS) involved in the biosynthesis of diterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens. Catalyzes the conversion of (+)-copalyl diphosphate ((+)-CPP) to isopimaradiene.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MALLSSSLSSHIPTGAHHLTLNAYANTQCIPHFFSTLNAGTSAGKRSSLYLRWGKGSNKIIACVGEDSVSAPTLLKREFPPGFWKDHVIDSLTSSHKVAASDEKRIETLISEIKNMFRSMGYGETNPSAYDTAWVARIPAVDGSEQPEFPETLEWILQNQLKDGSWGEGFYFLAYDRILATLACIITLTLWRTGEIQVQKGIEFFKTQAVKIEDEADSHRPSGFEIVFPAMLKEAKVLGLDLPYELPFIKKIIEKREAKLERLPTNILYALPTTLLYSLEGLQEIVDWQKIIKLQSKDGSFLTSPASTAAVFMRTGNKKCLEFLNFVLKKFGNHVPCHYPLDLFERLWAVDTVERLGIDRHFKEEIKDALDYVYSHWDERGIGWARENLVPDIDDTAMGLRILRLHGYNVSSDVLKTFRDENGEFFCFLGQTQRGVTDMLNVNRCSHVAFPGETIMEEAKTCTERYLRNALEDVGAFDKWALKKNIRGEVEYALKYPWHRSMPRLEARSYIEHYGPNDVWLGKTMYMMPYISNEKYLELAKLDFNHVQSLHQKELRDLRRWWTSSGFTELKFTRERVTEIYFSPASFMFEPEFATCRAVYTKTSNFTVILDDLYDAHGTLDDLKLFSDSVKKWDLSLVDRMPEDMKICFMGFYNTFNEIAEEGRKRQGRDVLGYIRNVWEIQLEAYTKEAEWSAARYVPSFDEYIENASVSIALGTVVLISALFTGEILTDDVLSKIGRGSRFLQLMGLTGRLVNDTKTYEAERGQGEVASAVQCYMKDHPEISEEEALKHVYTVMENALDELNREFVNNREVPDSCRRLVFETARIMQLFYMDGDGLTLSHETEIKEHVKNCLFHPVA
Protein: Uncharacterized protein (W5PGF6)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MTKRRKNLKNSNVLAGSRLLLLLVVSNLILCQGQAQHPPYCRNQPGKCQIPLQSLFDRATTVANYNSKLAGEMVNRFDEQYGQGINSESKVINCHTSSITTPNSKAEAINTEDKILFKLVISLLHSWDEPLHHAVTELANSKGTSPALLTKAQEIKEKAKVLVDGVEVIQKRIHPGEKNEPYPVWSEQSSLTSQDENVRRVAFYRLFHCLHRDSSKIYTYLRILKCRLTSCET