wanglab/gogpt-training-data huggingface dataset:
Protein: PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Peroxisome biogenesis factor 5-like) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b) (Q8IYB4)
Organism: Homo sapiens (Human)
Function: Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.
Subcellular location: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Some fraction is membrane associated via its interaction with RAB8B. {ECO:0000250}.
Interaction partners:
- Peroxisomal membrane protein PEX14
- Peroxisomal targeting signal 2 receptor
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX13
- Peroxisomal ATPase PEX6
- Ras-related protein Rab-8B
- Peroxisomal targeting signal 1 receptor
- Peroxisomal ATPase PEX1
- Peroxisome biogenesis factor 10
- Peroxisomal biogenesis factor 3
Sequence:
MYQGHMQKSKEQGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQTKAKKSEPSSKTSSLKKKADGSDLISTDAEQRGQPLRVPETSSLDLDIQTQLEKWDDVKFHGDRNTKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVAPTQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP
Protein: Segregation and condensation protein B (Q97NX6)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01804}. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells. {ECO:0000255|HAMAP-Rule:MF_01804}.
Interaction partners:
Sequence:
MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQKYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQPITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHLEELPVIDELEIQAQESQLFGERIEEDENQ
Protein: Beta-galactosidase 3 (Lactase 3) (EC 3.2.1.23) (Q9SCV9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Probable sarcosine oxidase
Sequence:
MREMGTGDSASRLILWFCLGFLILGVGFVQCGVTYDRKALLINGQRRILFSGSIHYPRSTPDMWEDLIQKAKDGGIDVIETYVFWNLHEPSPGKYDFEGRNDLVRFVKTIHKAGLYAHLRIGPYVCAEWNFGGFPVWLKYVPGISFRTDNEPFKRAMKGFTERIVELMKSENLFESQGGPIILSQIENEYGRQGQLLGAEGHNYMTWAAKMAIATETGVPWVMCKEDDAPDPVINTCNGFYCDSFAPNKPYKPLIWTEAWSGWFTEFGGPMHHRPVQDLAFGVARFIQKGGSFVNYYMYHGGTNFGRTAGGPFVTTSYDYDAPIDEYGLIRQPKYGHLKELHRAIKMCEKALVSADPVVTSIGNKQQAHVYSAESGDCSAFLANYDTESAARVLFNNVHYNLPPWSISILPDCRNAVFNTAKVGVQTSQMEMLPTDTKNFQWESYLEDLSSLDDSSTFTTHGLLEQINVTRDTSDYLWYMTSVDIGDSESFLHGGELPTLIIQSTGHAVHIFVNGQLSGSAFGTRQNRRFTYQGKINLHSGTNRIALLSVAVGLPNVGGHFESWNTGILGPVALHGLSQGKMDLSWQKWTYQVGLKGEAMNLAFPTNTPSIGWMDASLTVQKPQPLTWHKTYFDAPEGNEPLALDMEGMGKGQIWVNGESIGRYWTAFATGDCSHCSYTGTYKPNKCQTGCGQPTQRWYHVPRAWLKPSQNLLVIFEELGGNPSTVSLVKRSVSGVCAEVSEYHPNIKNWQIESYGKGQTFHRPKVHLKCSPGQAIASIKFASFGTPLGTCGSYQQGECHAATSYAILERKCVGKARCAVTISNSNFGKDPCPNVLKRLTVEAVCAPETSVSTWRP
Protein: Dynamin-type G domain-containing protein (Receptor-mediated endocytosis 1 isoform IV) (G5EFP1)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004159}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004159}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004159}.
Interaction partners:
Sequence:
MSNLFEEGQKKKKTRSMFSWLGGDSSKKKNKEVLETVSEGLRKIYKQKLLPLEEFHKFHDFHSPALDDPDFDAKPMILLVGQYSTGKTTFIRYLLESDFPGIRIGPEPTTDRFIAVMHGDEEGSIPGNALVVDAKKQFRALSGFGNAFLNRFQCSTLPNQVLESVTIVDTPGILSGEKQRIDRGYDFTGVLEWFAERVDRIILLFDAHKLDISDEFKRCIEALAGNEDKIRIVLNKSDMVDHQQLMRVYGALMWSLGKVFKTPEVSRVYLGSFWDHPLHYDLNRRLFQDEQHDLFQDLQALPRNAALRKLNDLIKRARLAKVHAYIIAELRKQMPSMIGKDKKKKDLIQNLDKIYEQLQREHNISPGDFPDVNKMREKLQTQDFSKFNPLKPKLLEVVDGMLATDIARLMAQIPKEEAAAPAGSNGSADPTVRGGAFSQTTEAETPFGFGRYDARWGEGFDKGADEAEWVVSRERTTADSTFESLGPVNGYLSGRAAKEHMVKSKLPNSVLGKVWKLADIDKDGQLDADEFALANYLINLKLEGHEIPSELPKHLIPPSKRGEQDPVYPSLNDNDE
Protein: Transmembrane protein 108 (Retrolinkin) (Q8BHE4)
Organism: Mus musculus (Mouse)
Function: Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.
Subcellular location: Membrane {ECO:0000269|PubMed:17287360}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000269|PubMed:28096412}. Endosome membrane {ECO:0000269|PubMed:17287360}. Cell projection, axon {ECO:0000269|PubMed:17287360, ECO:0000269|PubMed:21849472}. Cell projection, dendrite {ECO:0000269|PubMed:21849472}. Early endosome {ECO:0000269|PubMed:21849472}.
Interaction partners:
- Endophilin-A1
- Dystonin
Sequence:
MKRSLQALYCQLLSFLLTLALTKALVLAVHEPSPRESLQTLPSGSPPGTMVTAPHSPTRLSSVLTLNPTPDGPSSQAAATLETTVSHPEGHPPTDTTSTVMGTAAVPHPESPLPTGSPPAAMTTTPSHSESLPPGDATPTTTLPTKPAGTTSRPTVAPRATTRRPPRPPGSSRKGAGGSTRTLTPVPGGHLARKESQRGRNQSSAHLGPKRPLGKIFQIYKGNFTGSAEPDPSALTPRTPLGGYFSSTQPQTVSPATAPRSTSRVPPTTSLVPVKDKPGFIRSNQGSGPILTSPGGEPAATAATGAPASTQPAPVPSQSPHGDVQDSASHSDSWLAVTPDTDRPTSASSGVFTAATGPTQAAFDATVSAPSPGIPQGPSATPQAPTRPSGVSESTVSPAEEEAEASPTTTDRGPRPLSTVLSTATGNFLNRLVPAGTWKPGTVANISHVAEGDKPQHRATICLSKMDIAWVIVAISVPISSCSVLLTVCCMRRKKKTANPENNLSYWNNAITMDYFNRHAVELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI
Protein: Transcription factor bHLH53 (Basic helix-loop-helix protein 53) (AtbHLH53) (bHLH 53) (Transcription factor EN 123) (bHLH transcription factor bHLH053) (Q84RD0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MSMDCLSYFFNYDPPVQLQDCFIPEMDMIIPETDSFFFQSQPQLEFHQPLFQEEAPSQTHFDPFCDQFLSPQEIFLPNPKNEIFNETHDLDFFLPTPKRQRLVNSSYNCNTQNHFQSRNPNFFDPFGDTDFVPESCTFQEFRVPDFSLAFKVGRGDQDDSKKPTLSSQSIAARGRRRRIAEKTHELGKLIPGGNKLNTAEMFQAAAKYVKFLQSQVGILQLMQTTKKGSSNVQMETQYLLESQAIQEKLSTEEVCLVPCEMVQDLTTEETICRTPNISREINKLLSKHLAN
Protein: Large ribosomal subunit protein eL20B (60S ribosomal protein L20-B) (L18a) (P0CX24)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
Sequence:
MAHFKEYQVIGRRLPTESVPEPKLFRMRIFASNEVIAKSRYWYFLQKLHKVKKASGEIVSINQINEAHPTKVKNFGVWVRYDSRSGTHNMYKEIRDVSRVAAVETLYQDMAARHRARFRSIHILKVAEIEKTADVKRQYVKQFLTKDLKFPLPHRVQKSTKTFSYKRPSTFY
Protein: Probable hypothetical membrane protein (O06623)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Dethiobiotin synthetase BioD
- 8-amino-7-oxononanoate synthase 1
- Conserved protein
- Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Sequence:
MVTMTSWPSRLFAFTDNVCPPDACPLVPFGVNYYIYPVMWGGIGAAIATAVIGPFVSMLKGWYMSFWPIISIAVITVTSIAGYAIAGFSERYWH
Protein: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10) (Uracil phosphoribosyltransferase) (EC 2.4.2.9) (O61790)
Organism: Caenorhabditis elegans
Function: Phosphoribosyltransferase which catalyzes the formation of UMP from uracil in vitro and thus may be involved in UMP biosynthesis via the salvage pathway. May also participate in the first step of UMP synthesis by catalyzing the formation of orotidine 5'-phosphate, a UMP precursor, from orotate.
Interaction partners:
- Probable Golgi transport protein 1
- Trifunctional purine biosynthetic protein adenosine-3
- Dihydroorotate dehydrogenase
- Multifunctional protein pyr-1
- Dihydropyrimidine dehydrogenase [NADP
- Cytochrome-b5 reductase
- NADH-cytochrome b5 reductase
- NADH-cytochrome b5 reductase
- Protein unc-33
- Dihydropyrimidinase 1
Sequence:
MTAATATANGNHSIEDPVVMKVQAASPIQETDFFENLYQMECFRTGEFYLKSGQMTPIYIDLRRIMSSPRVLRMAAQAMCEKIVASNLKFDYVVGVPYAALPLATLVSDILNVPMLMKRKEAKAYGTKQLIEGVYQPGGTVLLVEDVVTSGESIRETAEAIRNENLLVTDAIAVLDRQQGATANLAEDNLNFLSFLTMEKILDGLITKNEMTEERKHEIIAHLAKPF
Protein: RB binding protein 4, chromatin remodeling factor (H0YEU5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
SKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMGRQRTFIMMKTLKEAWIQKDKGVSP
Protein: Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (mAGP7) (Ubiquitin-activating enzyme E1-like protein) (Q9D906)
Organism: Mus musculus (Mouse)
Function: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (By similarity). Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner.
Subcellular location: Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000269|PubMed:24089209}.
Interaction partners:
- Ubiquitin-like protein ATG12
- Ubiquitin-like-conjugating enzyme ATG3
- Autophagy protein 5
- Ubiquitin-like-conjugating enzyme ATG10
- Gamma-aminobutyric acid receptor-associated protein
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Gamma-aminobutyric acid receptor-associated protein-like 1
- Forkhead box protein O1
- Microtubule-associated protein 1 light chain 3 beta
- NAD-dependent protein deacetylase sirtuin-1
Sequence:
MGDPGLAKLQFAPFNSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPTRLTLEFSAFDMSASTPAHCCPAMGTLHNTNTLEAFKTADKKLLLEQSANEIWEAIKSGAALENPMLLNKFLLLTFADLKKYHFYYWFCCPALCLPESIPLIRGPVSLDQRLSPKQIQALEHAYDDLCRAEGVTALPYFLFKYDDDTVLVSLLKHYSDFFQGQRTKITVGVYDPCNLAQYPGWPLRNFLVLAAHRWSGSFQSVEVLCFRDRTMQGARDVTHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSGCMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHVTFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAAERLQKIFPGVNARGFNMSIPMPGHPVNFSDVTMEQARRDVEQLEQLIDNHDVIFLLMDTRESRWLPTVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPSHLVAPADLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSPKVLDQYEREGFTFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDEETV
Protein: Probable actin-related protein 8 (Q9US07)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Exhibits low basal ATPase activity, and unable to polymerize. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Actin-like protein arp5
- Chromatin-remodeling complex subunit ies6
- Actin
- Chromatin-remodeling ATPase INO80
- INO80 complex subunit 4
- RuvB-like helicase 1
- RuvB-like helicase 2
- SWI/SNF and RSC complexes subunit arp42
- Actin-related protein 4
- INO80 complex subunit 3
Sequence:
MAPKRKQPYTEEGIDFKFTQFQIVPPINQKNFYTEYLKRDDQMYIWRDSAGEKDAKETESESANGDTKQDDSKKSQVEEEEDGIEESELGEEKDNKTIVLHIGSQNLRIGLASNKTPTTVPMVIARKMRAPFAQERCLLKDICHVNEDGNVAFDSEFDSNLKLLDSELKSWLKAQKKRSVPNGTQLVKNYNKISKPETVPPDDDPEKPDWIHFEQDDHVDVICGKEAFLLPLNEYPEYKLFYPIKSGVFNESDYASSQQLLADIYEIFKYSITSLLQIPVSQLSQYSVIFIVPDLYDRVYVEKILDILFFDLHFGKAAIVQESLCTSFGAGMSAACVVDMGAQKTSISCVEEGVVVPNSRIKINYGGDDITLLFMKLLMRSHFPYQDIDLKTPYDWSLANALKIKYCGLSEATYNVQLNSFFSRTPDKGTRKFTFKSLDETMLAPLGFFRPDIFENENKLHDRYTLFPVPVDVYDNQPNNPESLAQTTLLQISTPISNIKANGKDDEEKKEESDLVTPSVKFKPPRVVYCGSLAAPEIKNEKLIYPLDDAINQSIFSACDGNLSDEKAKNLYSSILIVGGAGQFPGFAHLLEERIHSKRANIPTISVIPPPRSMDAQFVAWKGACIYNRIRIVSELWIKNSDWKMLGSRVLQYKTLGYFWTG
Protein: Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (mUSP25) (P57080)
Organism: Mus musculus (Mouse)
Function: Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16501887}. Nucleus {ECO:0000269|PubMed:16501887}. Note=The longer muscle-specific isoform (USP25m) Some transient punctuate nuclear location in myotubes during myocyte development.
Interaction partners:
- Antiviral innate immune response receptor RIG-I
- Ubiquitin carboxyl-terminal hydrolase 13
- Ubiquitin carboxyl-terminal hydrolase 5
- Polyubiquitin-C
Sequence:
MTVEQNVLQQSAAQKHQQTFLNQLREITGINDAQILQQALKDSNGNLELAVAFLTAKNAKTPPQEETGYYQTALPGNDRYISVGSQADANVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPIEVWRDSRNPYDRKRQEKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAMGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSDNSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSSASGPLPSQSLPSTTEQQGPCASDLPGSSSPASGAALPLRSVIHKPFTQSRIPPDLPMHPAPRHITEEELCVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYIDDKAQFLIQEEFNKETGQALVGMETLPPDLRDFVEEDNQRFEKELEEWDTQLAQRSLQEKLLAAPKLREAEASATTAQAGGADYLEQPSRSDLSKHWKEETLRVIAKASHDLEDKGPETVLQSAIKLEYSRLVKLAQEDTPPETDYRLHHVLVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHADYKKFRETTMYLITGLENFQRESYIDSLLFLLCAYQNNKELLSKGPYRGHDGELISHYRRECLLKLNEQAAELFESGEDGDVNNGLIIMNEFIVPFLPLLLVDDMEEKDILAVEDMRNRWCSYLGQEMEANLQEKLTDFLPKLLDCSTEIKGFHEPPKLPSYSAHELCERFARIMLSLSRTPADGR
Protein: SMY2 homolog 2 (Q02875)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- ATP-dependent RNA helicase DHH1
- E3 ubiquitin-protein ligase HEL2
Sequence:
MNPINSLAFDLHSVKLADANSDTAALSNSNTPTMNNAALLQRPSSIMDSIGVQRVPSPFVPGSNAISGASTVPFNAYDAEITGSPLQISANQENNSAFSAASSNLHMNASSPSVLNKPSSTFPNVAPYLYNATGPAPNVGNQPPPPGIESQWKYIDSNGNIQGPFGTNNMSQWYQGGYFTPTLQICRLATSPEPFGVNDRFIRLGELTTLVNNYQDPFVAFDFIVIRALNAVPLVAPTSSEKQKVESRDLIPVADVHSDDFTYEEILGLKFEDGSYYHETQVWVPVDGRHITKVDRIPKISAYTAPLSTTSSRSNKTTSSHEEKVPSHEEASPEEQEVFSEEGRTVSNITNEEESIVKNPTKQEEESRGSEKEQNILDQVQPEIEEVDRKDVISTADEPKSKDTPQMTSEEQKRFAKAELMAQKLLEEQQRQEEEKKRREEQRKLKKEKKLKQKQKKEEEKLKKKKKEEGKLEKEKQKELLNNILTGDTETPSSENTATSITTNLAPWANKKPEGAVYNQISSALEDLKKENSSKKEKKPNRTQLDREQALKLQKEILSSAQIPKTQTGSAWGIKPQQPIKVDIKGELMKDSTKINSQSKINKANNGDIKPDSTFIEEQKKLWEQVQKKTKKFNRASSLDDFISRTPSPSSSALNSSNTSNAWTTVSSKSTTHIASTMPVAGNQSKSYISLDTLRSSGGLSTATKTKMSDKSKQIGSSTSIPTLKARQVKPSRIPAYPGNASVSKRQEFLRWCRSQLKLNTGVQPDNVLEMLLSLPPGSESKEIIADTIYSYSSTMDGRRFATDFIKKRLECEEEINDPLSWSEVLAMPEGSSEDWEFQVVGKKKGKRF
Protein: Late embryogenesis abundant protein (LEA) family protein (Q9T0H6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Putative F-box protein At3g10430
- Probable methyltransferase PMT22
- Vacuolar protein sorting-associated protein 20 homolog 1
- Hyperosmolality-gated Ca2+ permeable channel 2.4
- Pectin lyase-like superfamily protein
- Probable pectinesterase/pectinesterase inhibitor 21
Sequence:
MSQQQFNAGQNRGQAQEKAEQWTESAKQTAQSACDKTADLTQSARDKAADLTQSARDKTADGSHSANKSAQHNQEQAAGLFGQTGESVKNMAQGALDGVKNSLGMNEKK
Protein: F-box protein CPR1 (Protein CONSTITUTIVE EXPRESSER OF PR GENES 1) (Protein CONSTITUTIVE EXPRESSER OF PR GENES 30) (Q9SU30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates negatively both salicylic acid (SA)-dependent and SA-independent defense signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19682297}. Nucleus {ECO:0000269|PubMed:19682297}.
Interaction partners:
- Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1
- SKP1-like protein 1A
- Early nodulin-like protein 5
- Putative UPF0481 protein At3g02645
- Protein SUPPRESSOR OF NIM1 1
- Suppressor of RPS4-RLD 1
- Small ribosomal subunit protein uS19v
- Cysteine and histidine-rich domain-containing protein RAR1
- Negative regulator of systemic acquired resistance SNI1
Sequence:
MATIPMDIVNDIFLRLPAKTLVRCRALSKPCYHLINDPDFIESHLHRVLQTGDHLMILLRGALRLYSVDLDSLDSVSDVEHPMKRGGPTEVFGSSNGLIGLSNSPTDLAVFNPSTRQIHRLPPSSIDLPDGSSTRGYVFYGLGYDSVSDDYKVVRMVQFKIDSEDELGCSFPYEVKVFSLKKNSWKRIESVASSIQLLFYFYYHLLYRRGYGVLAGNSLHWVLPRRPGLIAFNLIVRFDLALEEFEIVRFPEAVANGNVDIQMDIGVLDGCLCLMCNYDQSYVDVWMMKEYNVRDSWTKVFTVQKPKSVKSFSYMRPLVYSKDKKKVLLELNNTKLVWFDLESKKMSTLRIKDCPSSYSAELVVSSLVLGCKGDLNNIKYRKEQQAKEAREAKIMQNTKRRDDFLSKGFKLVL
Protein: Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4) (Q8IVL5)
Organism: Homo sapiens (Human)
Function: Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position.
Subcellular location: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:15063763}. Sarcoplasmic reticulum {ECO:0000305|PubMed:15063763}. Golgi apparatus {ECO:0000269|PubMed:15063763}.
Interaction partners:
- Prolyl 4-hydroxylase subunit alpha-2
- Protein disulfide-isomerase
- Prolyl 4-hydroxylase subunit alpha-1
- Collagen alpha-2
Sequence:
MRERIWAPPLLLLLPLLLPPPLWGGPPDSPRRELELEPGPLQPFDLLYASGAAAYYSGDYERAVRDLEAALRSHRRLREIRTRCARHCAARHPLPPPPPGEGPGAELPLFRSLLGRARCYRSCETQRLGGPASRHRVSEDVRSDFQRRVPYNYLQRAYIKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILDQEQQGKHELNINPKDEL
Protein: Aquaporin-11 (AQP-11) (Q8NBQ7)
Organism: Homo sapiens (Human)
Function: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24918044, ECO:0000269|PubMed:31546170}; Multi-pass membrane protein {ECO:0000269|PubMed:24918044}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:28042826}; Multi-pass membrane protein {ECO:0000269|PubMed:24918044}. Cell membrane {ECO:0000250|UniProtKB:F6S3G9}; Multi-pass membrane protein {ECO:0000269|PubMed:24918044}. Note=Localizes mainly to the periphery of lipid droplets (PubMed:24845055). Localizes to cytoplasmic vesicles in maturing spermatozoa (PubMed:28042826). It accumulates partly in mitochondrial-associated endoplasmic reticulum membranes (PubMed:31546170). {ECO:0000269|PubMed:24845055, ECO:0000269|PubMed:28042826, ECO:0000269|PubMed:31546170}.
Interaction partners:
- Aquaporin-7
- Aquaporin-8
- Aquaporin-10
- Lens fiber major intrinsic protein
- Aquaporin-3
- Aquaporin-5
- Aquaporin-6
- Aquaporin-9
- Aquaporin-2
- Aquaporin-1
Sequence:
MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVAHAFVLEFLATFQLCCCTHELQLLSEQHPAHPTWTLTLVYFFSLVHGLTLVGTSSNPCGVMMQMMLGGMSPETGAVRLLAQLVSALCSRYCTSALWSLGLTQYHVSERSFACKNPIRVDLLKAVITEAVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVYAGGSLTGAVFNPALALSLHFMCFDEAFPQFFIVYWLAPSLGILLMILMFSFFLPWLHNNHTINKKE