wanglab/gogpt-training-data huggingface dataset:
Protein: Galactose-specific cell agglutination protein gsf2 (Galactose-specific flocculin) (Pombe flocculin 1) (Q9P6S0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Galactose-specific adhesion protein essential for non-sexual flocculation and filamentous growth. Required for adhesion and filamentous growth through recognition of galactose residues on cell surface glycoconjugates. Induces flocculation when overexpressed.
Subcellular location: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.
Interaction partners:
- Uncharacterized transcriptional regulatory protein C15D4.02
- MADS-box transcription factor pvg4
- Putative cell agglutination protein pfl3
- Putative cell agglutination protein pfl8
- Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02
- Transcription factor cbf12
- Large ribosomal subunit protein eL27B
- Smr domain-containing protein C1235.03
Sequence:
MSVRRFLSTSARALLFTAALLPSLTSGLPSGNVRILQKGMEPEDYLSSASQNEVPHDISLPKTELADPNFLVDDMPTLLGRDAAVDPSMFTSTFTVKNGNDANYITASPVSNDASMTAISTFTSGKEASYAIQASPSTFLPDSTTTSGSQVSNAVEASSTFVADTTSTSCNPATVLIVTTSGSTSTSCPPPTTILIVTVPTTTTTTTVGYPGSVTTTLTGTPSNGTVIDTVEVPTTTNYGYTTITTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYPGSVTTTLTGAPSNGTVIDTVEVPTTTNYGYTTVTTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYPGSVTTTLTGAPSNGTVIDTVEVPTTTNYGYTTVTTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYPGSVTTTLTGAPSNGTVIDTVEIPTTTNYGYTTITTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYPGSVTTTLTGAPSNGTVIDTVEVPTTTNYGYTTITTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYPGSVTTTLTGAPSNGTVIDTVEVPTTTNYGYTTVTTGYTGSTTLTTTVPHSGNETGPTTVYVETPYPTTVTTTTTVGYSGSVTTTLTGSGSNSIVTETVDVPTTTSVNYGYTTITTGWTGSTTLTSIVTHSGSETGPTTVYIETPSVSATTTTTTIGYSGSLTTTLTGSSGPVVTNTVEIPYGNSSYIIPTTIVTGTVTTVTTGYTGTETSTVTVIPTGTTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTSTGTTTVVIQTPTTVTATETDIVTVTTGYTGTETSTVTVTPTGTATGTTTVVINTPTTTGSEVLPTTGATGTAGTETQLTTATEVQPTTGATGTAGTETQVTTGTETQATTATETQATTATEVQTTTGATGTAGTETQATTATEVQPTTGATGTAGTETQVTTATEVQPTTGATGTAGTETQVTTGTETQATTATETQATTATEVQTTTGATGTAGTETQATTATEVQPTTGATGTAGTETQVTTATEVQPTTGATGTAGTETQVTTGTETQATTATETQATTATEVQTTTGATGTAGTETQVTTATEVQPTTAVTETSSSGYYTTIVSSTVVSTVVPGSTVYPVTHVTTTTGVSGESSAFTYTTSSTQYEPSTVVTTSYYTTSVYTSAPATETVSSTEAPESSTVTSNPIYQGSGTSTWSTVRQWNGSATYNYTYYTTGGFTGGNNTNVTGLYPSSAGANKPIAYLTFVSLFVYIVTLI
Protein: GP5 (D6P3F7)
Organism: Porcine reproductive and respiratory syndrome virus (PRRSV)
Interaction partners:
Sequence:
MRCSYKLGRSLTPHSYFWWLFLLCTGLSWSFADGNGNSSTYQYIYNLTICELNGTTWLSDRFGWAVEAFVLYPVVTHILSLGFLTTSHFFDALGLGAVSVTGYYDGRYVLSSVYGTCALAALVCFAIRAAKNCMACRYARTRFTNFIVDDRGGVHRWKSPIVVEKLGKAEVGDALVTIKHVVIEGVKAQPLTRTSAEQWQA
Protein: Protein HRI1 (Q6FR71)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MSAVLFKRLVFQVGDSANERTFTLSSVSKNGHFISLRPFTKPTEDEKKFPLEWVFAGTNDRVKVTPTTNADGKPVLQQDFDMGFDTNVYLNVENTHRGVINTFWQNWESGCVEETGKVFPFGNDKEGIPFMELWQPIDPNSKDLVILDAGDGRKIDGPVRSTVLKVVDGQDFEGLMIIVGEWAQGYLADKNKSSVDGLSFVRYHVSNEKLSSGLFEYGSQLSKFPTDFSNVKEGSLLTIDGLKWEVIEN
Protein: Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Orphan nuclear receptor OR-1) (Ubiquitously-expressed nuclear receptor) (UR) (Q62755)
Organism: Rattus norvegicus (Rat)
Function: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (By similarity). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Retinoic acid receptor RXR-beta
- Retinoic acid receptor RXR-alpha
- P-type phospholipid transporter
- Nuclear receptor coactivator
- Oxysterols receptor LXR-alpha
- Nuclear receptor coactivator 2
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
- Nuclear receptor corepressor 2
- ATP binding cassette subfamily G member 1
- Nuclear receptor corepressor 1
Sequence:
MSSPTSSLDTPLPGNGSPQPSTSSTSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKKIQKQQQQQPPPPTEPASGSSARPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Protein: Proline and serine rich coiled-coil 1 (Q5T2Z0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MEDLEEDVRFIVDETLDFGGLSPSDSREEEDITVLVTPEKPLRRGLSHRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEANRLAAQLEQCALQDRESAGEGLGPRRVKPSPRRETFVLKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSGKRPSNMKRESPTCNLFPASKSPASSPLTRSTPPVRGRAGP
Protein: Nicotinamide nucleotide adenylyltransferase 1 (B1AN62)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MENSEKTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGLIPAYHRVIMAELATKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLEASDCDHQQNSPTLERPGRKRKWTETQDSSQKKSLEPKTKDGVSLYHPGWSAVA
Protein: Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (CRE-BPa) (Q8K1L0)
Organism: Mus musculus (Mouse)
Function: Binds to the cAMP response element and activates transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cyclic AMP-dependent transcription factor ATF-2
- Cyclic AMP-responsive element-binding protein 1
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 3
- Cyclic AMP-responsive element-binding protein 3
- Histone lysine acetyltransferase CREBBP
- Histone acetyltransferase p300
- Cyclic AMP-dependent transcription factor ATF-4
- Cyclic AMP-responsive element-binding protein 3-like protein 4
- cAMP-dependent protein kinase catalytic subunit beta
Sequence:
MSMRPVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMSTIGHMMEMMGSRQDQTPHHHLHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPAHHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLNPIL
Protein: Mitochondrial ATP-dependent zinc metallopeptidase, putative (EC 3.4.24.-) (Q584A7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Prohibitin
- Prohibitin
Sequence:
MFRIPRSAHLSFAAAALQTSKCFCATGSNSDGKADAPKEGEKATVAGGVSSKSRSNNNTSNTNTSDSNAAVGRAPGLSSEKRYPKGFEAFYSVSLLRRLPFSRPSSESVNRAYAMSSDERMLIAIISAKARKARRVRMLVIFSCLFGVTMAVRFYFLHSRAEGDISGYTTVEVDLAGHRAVFRGQKGEALGVRNFVDYRAFEASCDSNKDILVGIQTYYPWVPMLLLCLLPLLALTHSLFNTSARLASLTAEKSSYSFKRELSVATRLSDVAGLTEAKHEVVEVIDFLKNPSRYQALGAKLPKGVLLDGPPGVGKTLLAKAIAGEAMVPFLSCSGSEFEEVYVGVGAQRARELFKQAHECKPCVVFVDEIDAFGRKRKSDSGGSLRGTLNAFLSEMDGFKDSTGIMVLAATNRADILDNALTRSGRFDRKITLEKPSHKDRVAIAEVHLAPLKLEPSGTIRGFAETVAALTPGCSGADIFNICNEAAIQAAREGKEYVSTRHFHQAVDRVLVGLEKSAVKLSDAERERISFHEAGKVVLHWFQEKTDPVIKTTILPRGQHRSGVTQKLPQTAFISTQEQLMQGMVAQLGGYVAEEYFFKDVSTSAADDVQHATNRARQVVCTYGMDPENIGHFGYNLDQEDSIQKPFGPLKEDIVDEAVHKLITEALNRARSILKQYLREVRALAGLLARQETLTAHELWLLLGDRPVMTKEFRTYLES
Protein: Regulator of microtubule dynamics protein 1 (P34560)
Organism: Caenorhabditis elegans
Function: Acts in chromosome segregation and organization during mitosis.
Subcellular location: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}.
Interaction partners:
- Uncharacterized protein
- RNA-binding protein pos-1
- GRIP and coiled-coil domain-containing protein 2
Sequence:
MESFATSDKLFESREFVKGLEELKKRREDGEMTCDLLWRMCRFCHELSTTMSGEQRRKMLIEGRDYGLEAMDLDPSSFLAAKWTAIMFGLVVDQLPTKEKINDGGRLKDMLDKALELDPTDFALLHLRARFSYTIANLSWLERKAASMLYSEVPKATIDDALVDFKAAYNQNADWIENLLFLSKCHLAKKEKQQAREMLNKAIVLPAASSNDAQFVTECKSLLQKC
Protein: Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) (O94875)
Organism: Homo sapiens (Human)
Function: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:9211900}. Apical cell membrane {ECO:0000269|PubMed:18559503}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Cell projection, lamellipodium {ECO:0000269|PubMed:18559503}. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. {ECO:0000269|PubMed:18559503}.
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- Tyrosine-protein kinase ABL1
- Vacuolar protein sorting-associated protein VTA1 homolog
- GTP cyclohydrolase 1
- Vinculin
- SHC-transforming protein 2
- Palladin
- PDZ and LIM domain protein 3
Sequence:
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Protein: Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (CD antigen CD11b) (P05555)
Organism: Mus musculus (Mouse)
Function: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8986723, ECO:0000269|PubMed:9862668}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P11215}. Membrane raft {ECO:0000250|UniProtKB:P11215}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P11215}.
Interaction partners:
- Thy-1 membrane glycoprotein
- Intercellular adhesion molecule 2
- Integrin beta-2
- Intercellular adhesion molecule 1
- Junctional adhesion molecule C
- Complement C3
- Integrin alpha-L
- Vascular cell adhesion protein 1
- Integrin beta-2-like protein
- Platelet glycoprotein Ib alpha chain
Sequence:
MTLKALLVTALALCHGFNLDTEHPMTFQENAKGFGQNVVQLGGTSVVVAAPQEAKAVNQTGALYQCDYSTSRCHPIPLQVPPEAVNMSLGLSLAVSTVPQQLLACGPTVHQNCKENTYVNGLCYLFGSNLLRPPQQFPEALRECPQQESDIVFLIDGSGSINNIDFQKMKEFVSTVMEQFKKSKTLFSLMQYSDEFRIHFTFNDFKRNPSPRSHVSPIKQLNGRTKTASGIRKVVRELFHKTNGARENAAKILVVITDGEKFGDPLDYKDVIPEADRAGVIRYVIGVGNAFNKPQSRRELDTIASKPAGEHVFQVDNFEALNTIQNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSASITSNGPLLGSVGSFDWAGGAFLYTSKDKVTFINTTRVDSDMNDAYLGYASAVILRNRVQSLVLGAPRYQHIGLVVMFRENFGTWEPHTSIKGSQIGSYFGASLCSVDMDADGNTNLILIGAPHYYEKTRGGQVSVCPLPRGRARWQCEALLHGDQGHPWGRFGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFYGASIASLSASHSHRIIGAHFSPGLQYFGQSLSGGKDLTMDGLMDLAVGAQGHLLLLRAQPVLRLEATMEFSPKKVARSVFACQEQVLKNKDAGEVRVCLRVRKNTKDRLREGDIQSTVTYDLALDPVRSRIRAFFDETKNNTRRRTQVFGLMQKCETLKLILPDCVDDSVSPIILRLNYTLVGEPLRSFGNLRPVLAMDAQRFFTAMFPFEKNCGNDSICQDDLSITMSAMGLDTLVVGGPQDFNMSVTLRNDGEDSYGTQVTVYYPSGLSYRKDSASQNPLTKKPWFVKPAESSSSSEGHGALKSTTWNINHPIFPANSEVTFNVTFDVDSHASFGNKLLLKAIVASENNMSRTHKTKFQLELPVKYAIYMIVTSDESSIRYLNFTASEMTSKVIQHQYQFNNLGQRSLPVSVVFWIPVQINNVTVWDHPQVIFSQNLSSACHTEQKSPPHSNFRDQLERTPVLNCSVAVCKRIQCDLPSFNTQEIFNVTLKGNLSFDWYIKTSHGHLLLVSSTEILFNDSAFALLPGQESYVRSKTETKVEPYEVHNPVPLIVGSSIGGLVLLALITAGLYKLGFFKRQYKDMMNEAAPQDAPPQ
Protein: Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] (P68134)
Organism: Mus musculus (Mouse)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Myosin light chain 1/3, skeletal muscle isoform
- Tropomyosin alpha-1 chain
- Unconventional myosin-Ib
- Myosin-4
- Vasodilator-stimulated phosphoprotein
- Myosin regulatory light chain 11
- Tropomyosin beta chain
- Troponin C, skeletal muscle
- Unconventional myosin-XV
- Alpha-actinin-2
Sequence:
MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
Protein: SPRY domain-containing SOCS box protein 2 (SSB-2) (Gene-rich cluster protein C9) (Q99619)
Organism: Homo sapiens (Human)
Function: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
Subcellular location: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
Interaction partners:
- Elongin-C
- Cullin-5
- Nitric oxide synthase, inducible
- Cytokine-inducible SH2-containing protein
- Elongin-B
- PRKC apoptosis WT1 regulator protein
- RING-box protein 2
Sequence:
MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ
Protein: Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Glucosidase I) (A0A384MDR6)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648, ECO:0000256|RuleBase:RU368089}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648, ECO:0000256|RuleBase:RU368089}.
Interaction partners:
Sequence:
MARGERRRRAVPAEGVRTAERAARGGPGRRDGRGGGPRSTAGGVALAVVVLSLALGMSGRWVLAWYRARRAVTLHSAPPVLPADSSSPAVAPDLFWGTYRPHVYFGMKTRSPKPLLTGLMWAQQGTTPGTPKLRHTCEQGDGVGPYGWEFHDGLSFGRQHIQDGALRLTTEFVKRPGGQHGGDWSWRVTVEPQDSGTSALPLVSLFFYVVTDGKEVLLPEVGAKGQLKFISGHTSELGDFRFTLLPPTSPGDTAPKYGSYNVFWTSNPGLPLLTEMVKSRLNSWFQHRPPGAPPERYLGLPGSLKWEDRGPSGQGQGQFLIQQVTLKIPISIEFVFESGSAQAGGNQALPRLAGSLLTQALESHAEGFRERFEKTFQLKEKGLSSGEQVLGQAALSGLLGGIGYFYGQGLVLPDIGVEGSEQKVDPALFPPVPLFTAVPSRSFFPRGFLWDEGFHQLVVQRWDPSLTREALGHWLGLLNADGWIGREQILGDEARARVPPEFLVQRAVHANPPTLLLPVAHMLEVGDPDDLAFLRKALPRLHAWFSWLHQSQAGPLPLSYRWRGRDPALPTLLNPKTLPSGLDDYPRASHPSVTERHLDLRCWVALGARVLTRLAEHLGEAEVAAELGPLAASLEAAESLDELHWAPELGVFADFGNHTKAVQLKPRPPQGLVRVVGRPQPQLQYVDALGYVSLFPLLLRLLDPTSSRLGPLLDILADSRHLWSPFGLRSLAASSSFYGQRNSEHDPPYWRGAVWLNVNYLALGALHHYGHLEGPHQARAAKLHGELRANVVGNVWRQYQATGFLWEQYSDRDGRGMGCRPFHGWTSLVLLAMAEDY
Protein: Ent-isokaurene C2/C3-hydroxylase (EC 1.14.14.76) (Cytochrome P450 71Z6) (A3A871)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Enzyme of the diterpenoid metabolism involved in the biosynthesis of antibacterial oryzalides such as phytocassane.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Nitrate reductase
- Nitrate reductase 1
- Nitrate reductase
- 4-coumarate--CoA ligase
Sequence:
MEDKLILDLCLSALFVVVLSKLVSSAMKPRLNLPPGPWTLPLIGSLHHLVMTKSPQTHRSLRALSEKHGPIMQLWMGEVPAVVVSSPAVAEEVLKHQDLRFADRHLTATTEEVFFGGRDVIFGPYSERWRHLRKICMQELLTAARVRSFQGVREREVARLVRELAADAGAGGDAGVNLNERISKLANDIVMVSSVGGRCSHRDEFLDALEVAKKQITWLSVADLFPSSKLARMVAVAPRKGLASRKRMELVIRRIIQERKDQLMDDSAAGAGEAAAGKDCFLDVLLRLQKEGGTPVPVTDEIIVVLLFDMISGASETSPTVLIWTLAELMRNPRIMAKAQAEVRQAVAGKTTITEDDIVGLSYLKMVIKETLRLHPPAPLLNPRKCRETSQVMGYDIPKGTSVFVNMWAICRDSRYWEDPEEYKPERFENNSVDYKGNNFEFLPFGSGRRICPGINLGVANLELPLASLLYHFDWKLPNGMAPKDLDMHETSGMVAAKLITLNICPITHIAPSSA
Protein: Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM5) (TRIM5alpha) (Q5D7I0)
Organism: Saimiri sciureus (Common squirrel monkey)
Function: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by simian immunodeficiency virus (SIV-mac). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q0PF16}. Nucleus {ECO:0000250|UniProtKB:Q0PF16}. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1. {ECO:0000250|UniProtKB:Q0PF16}.
Interaction partners:
Sequence:
MASRILGSIKEEVTCPICLELLTEPLSLDCGHSFCQACITANHKESMLHQGERSCPLCRLPYQSENLRPNRHLASIVERLREVMLRPEERQNVDHCARHGEKLLLFCEQDGNIICWLCERSQEHRGHNTFLVEEVAQKYREKLQVALETMRQKQQDAEKLEADVRQEQASWKIQIQNDKTNIMAEFKQLRDILDCEESNELQNLEKEEKNILKRLVQSENDMVLQTQSVRVLISDLERRLQGSVVELLQDVDGVIKRIEKVTLQKPKTFLNEKRRVFRAPDLKRMLQVLKELTEVQRYWAHVTLVPSHPSYTIISEDGRQVRYQKPIRHLLVKVQYFYGVLGSPSITSGKHYWEVDVSNKRAWTLGVCVSLKCTANQSVSGTENYQPKNGYWVIGLRNAGNYRAFQSSFEFRDFLAGSRLTLSPPLIVPLFMTICPNRVGVFLDYEARTISFFNVTSNGFLIYKFSDCHFSYPVFPYFNPMTCELPMTLCSPRS
Protein: Large ribosomal subunit protein eL13z (60S ribosomal protein L13-1) (Protein BBC1 homolog) (P41127)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein eL31x
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein uL1z
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL13y
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein uL4y
Sequence:
MKHNNVIPNGHFKKHWQNYVKTWFNQPARKTRRRIARQKKAVKIFPRPTSGPLRPVVHGQTLKYNMKVRTGKGFTLEELKAAGIPKKLAPTIGIAVDHRRKNRSLEGLQTNVQRLKTYKTKLVIFPRRARKVKAGDSTPEELANATQVQGDYLPIVREKPTMELVKLTSEMKSFKAFDKIRLERTNKRHAGARAKRAAEAEKEEKK
Protein: Putative actin-depolymerizing factor 11 (ADF-11) (AtADF11) (Q9LZT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O49606}.
Interaction partners:
- Profilin-4
- Profilin-3
- Profilin-5
- Profilin-1
- Profilin-2
- Cyclase-associated protein 1
- Villin-5
- Uncharacterized protein F9K21.80
- Reverse transcriptase-like protein
- Villin-1
Sequence:
MVLHDDCKLTFLELKERRTFRSIVYKIEDNMQVIVEKHHYKKMHGEREQSYEEFANSLPADECRYAILDIEFVPGERKICFIAWSPSTAKMRKKMIYSSTKDRFKRELDGIQVEFHATDLTDISLDAIRRRIN
Protein: MiRP K channel accessory Subunit (Q86S20)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MFYFLLVQWSKADNPVLTHFQIFCLVIIGIGFLIILILIFSIFKSEMKSDSHARRFFHIWPLVHIALSTAYQLFTQIVISHWKTYQIPILYSSYATTVSVCIHLVLHSMAVFWKV