wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) (Q8NCN4)
Organism: Homo sapiens (Human)
Function: Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization. Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
Subcellular location: Chromosome {ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. Nucleus, nucleoplasm {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products. {ECO:0000269|PubMed:30104380}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 7
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
- Polyubiquitin-C
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B
- Mediator of DNA damage checkpoint protein 1
- DDB1- and CUL4-associated factor 7
- TP53-binding protein 1
- E3 ubiquitin-protein ligase RNF168
- Histone H2A type 2-A
- Histone H2A type 2-C
Sequence:
MAAAGPSTRASSAAAAAALSRRGRRGRCDETAAAKTGAPGPASGPSLLVLSPPLLQPPLPPRPEESGCAGCLEPPGEAAALPCGHSLCRGCAQRAADAAGPGCPRCRARGPGWARRRARDDGQADSEVLGECARRSQPERCRPRRDGGAAAAGPRPEQEPRAAPAEPDFIFRAPIKLSKPGELREEYESLRKLREEKLQEEKPSEDQIHKLLPEDTETGKRKMDEQKKRDEPLVLKTNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFLAGKLNSKVERSQSCSDTAQERAKSRVRAVPGNKAKVTTMTPASNPIIGVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSPESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLNRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEMGEELLGSEGIHSSKEKPLVAVNTRLSGGQVLSEYTGPTSADLDHFPSVSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFEGLGSTPDAKLDKTCISRAMKITTVNSVLPQNSVLGGVLKTKQQLKTLNHFDLTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKKLRQTSGEVGLAPTDPVLREMEQKLQQEEEDRQLALQLQRMFDNERRTVSRRKGSVDQYLLRSSNMAGAK
Protein: Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) (P11627)
Organism: Mus musculus (Mouse)
Function: Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q05695}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q05695}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q05695}. Note=Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons. {ECO:0000250|UniProtKB:Q05695}.
Interaction partners:
- Neuropilin-1
- Contactin-2
- Signal transducer CD24
- Ankyrin-1
- Ankyrin-2
- Neural cell adhesion molecule 1
- Epidermal growth factor receptor
- Ran-binding protein 9
- Integrin beta-1
- Neural cell adhesion molecule 2
Sequence:
MVVMLRYVWPLLLCSPCLLIQIPDEYKGHHVLEPPVITEQSPRRLVVFPTDDISLKCEARGRPQVEFRWTKDGIHFKPKEELGVVVHEAPYSGSFTIEGNNSFAQRFQGIYRCYASNKLGTAMSHEIQLVAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAAPPRIYWMNSKIFDIKQDERVSMGQNGDLYFANVLTSDNHSDYICNAHFPGTRTIIQKEPIDLRVKPTNSMIDRKPRLLFPTNSSSRLVALQGQSLILECIAEGFPTPTIKWLHPSDPMPTDRVIYQNHNKTLQLLNVGEEDDGEYTCLAENSLGSARHAYYVTVEAAPYWLQKPQSHLYGPGETARLDCQVQGRPQPEITWRINGMSMETVNKDQKYRIEQGSLILSNVQPTDTMVTQCEARNQHGLLLANAYIYVVQLPARILTKDNQTYMAVEGSTAYLLCKAFGAPVPSVQWLDEEGTTVLQDERFFPYANGTLSIRDLQANDTGRYFCQAANDQNNVTILANLQVKEATQITQGPRSAIEKKGARVTFTCQASFDPSLQASITWRGDGRDLQERGDSDKYFIEDGKLVIQSLDYSDQGNYSCVASTELDEVESRAQLLVVGSPGPVPHLELSDRHLLKQSQVHLSWSPAEDHNSPIEKYDIEFEDKEMAPEKWFSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSESVVTPEAAPEKNPVDVRGEGNETNNMVITWKPLRWMDWNAPQIQYRVQWRPQGKQETWRKQTVSDPFLVVSNTSTFVPYEIKVQAVNNQGKGPEPQVTIGYSGEDYPQVSPELEDITIFNSSTVLVRWRPVDLAQVKGHLKGYNVTYWWKGSQRKHSKRHIHKSHIVVPANTTSAILSGLRPYSSYHVEVQAFNGRGLGPASEWTFSTPEGVPGHPEALHLECQSDTSLLLHWQPPLSHNGVLTGYLLSYHPVEGESKEQLFFNLSDPELRTHNLTNLNPDLQYRFQLQATTQQGGPGEAIVREGGTMALFGKPDFGNISATAGENYSVVSWVPRKGQCNFRFHILFKALPEGKVSPDHQPQPQYVSYNQSSYTQWNLQPDTKYEIHLIKEKVLLHHLDVKTNGTGPVRVSTTGSFASEGWFIAFVSAIILLLLILLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE
Protein: Arf-GAP with ANK repeat and PH domain-containing protein cnt-2 (Centaurin-gamma-like protein cnt-2) (Q9XX14)
Organism: Caenorhabditis elegans
Function: GTPase-activating protein for the ADP ribosylation factor family (Probable). During neurogenesis, involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell probably by controlling endocytosis. In oocytes, involved in vitellogenin vit-2 uptake by regulating receptor rme-2 endocytosis.
Interaction partners:
- Rho-GAP domain-containing protein
- Target of ERK kinase mpk-1
- DEP domain-containing protein
- Protein HGH1 homolog
- Maternal embryonic leucine zipper kinase
- Stork-head box protein ham-1
Sequence:
MPLIRNYDYYDLLNVAPSTSAHRPTVMVTSSRSYMEPQKSRIYYGKNEWRGGNTTIHDPTEFEETTMDKNANEIAGDDKRKKKRWRDLLFPNSRHSSRKDKENSNVSVATRSLSSVSFRSEKPSRRRESGSLSRHRYIPPPPLPMPPRRIMTSTSMGYSDDAMTSSSSHTTTDYDDIVPVPTPSYVIYPAASIAQASRRQQQGSAKNRIFRSPTYHHDAFVNSHEWTLSRSISEMKLGIVGTSQSGKTALVHRYLTGTYTPDESPEGGRFKKEVVIEGQSHLLLIRDEGQQHLDVQFCQWVDAVVFVFNVCSIQSYDSIQALAHEMSKYRNISDLPLILVGTKDHISEKRARVITEDEGRQLAAQMKRCSYFETSSTYGTNVERVFKEACCKIIQLRVRSQVGAAAAASSQARTPTPTHSESGGRKDYQDPSRYISSNSFVMPSNMRPSFPSNSTRRNTVHHRGEHPQQQQYQQQPPSSSRTASERSMSAMLGTPYGNRMPAGVSPSASQKSVHSIANGCYSRSSAALLDSDTPAVNSYLIDSMSSAGFPLSQSGANQVSASTSHLPTPSSTPNTQRKNRRISNIFRQKDHQEEKSKMIESLNLGIGRAIPIKQGNLYKKSSKSALNREWKKKYVCLYSDGRLTYHTNLKEYMDKTAHGKEMDLKLATIRITGRLHPLHSHRVASSVDPMNGGGGGGTPTLKSYEPRRSDVGANSGDGTSGGGSDDAIKENQRQHFSPPAMPQTVAGKKKRESRKIGTNSKHNDEEDECFEVINNCLMRWEFCAGSLEERDEWIQAIGGEIEKSLGKEVANAKTNNRAVANRPDIAALRSIPGNGRCADCGNPSSEWASINLGIIICIECSGIHRNLGSHISKVRGLELDQWPVEHLAVMQAIGNDKANEMWEFGLLNGERKPTPESSREEKERFIDRKYVQKAFLKPIASGEPVTSQLISAVLARDVMSLNVLLANGMSVEEINTTTKDGRTVLHLAASIGSVELAQLLIWHNADAQILDNNGRSCLFYARSNGFREVFDMLVTAGLSPDYGLPQEINDFSQMPEFFAMGSTSNRDYSTSGDEMYGSRRISMGPPPQVPARRYLPQQPELDETSVI
Protein: Fibroblast growth factor receptor 1-A (FGFR-1-A) (bFGF-R-1-A) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1-A) (Q90Z00)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus (By similarity). {ECO:0000250}.
Interaction partners:
- Fibroblast growth factor
- Fibroblast growth factor 8
- Putative fibroblast growth factor 1
- Anosmin 1a.
- Fibroblast growth factor 23
- Fibroblast growth factor
- Fibroblast growth factor
- Son of sevenless homolog 1
- Fibroblast growth factor
- Fibroblast growth factor 8b
Sequence:
MKMMMIMKTTLLLISVLLTQALQSQGRPAIQDEAPAEPTSYTLDSGEKLELSCKAKEDTQKVTWTKDLVPLVDGEHTRLRNDQMEIEKVEPTDSGLYACFAQGLNSNHTEYFNISVTDEEDEVDSSSEEAKLSNDQNLPMAPVWAQPDKMEKKLHAVPASKTVKFRCQANGNPTPTLKWLKNGKEFKRDQRIGGFKVREHMWTIIMESVVPSDRGNYTCLVENRHGSINHTYQLDVVERSPHRPILQAGLPANRTAVVGSDVEFECKVFSDPQPHIQWLKHIEVNGSRYGPDGLPYVRALKTAGVNTTDKEMEVLQIRNVSLEDAGEYTCLAGNSIGHSHHSAWLTVYKAVPPTQLPNQTYLEVLIYCVGFFLICVMVGTAVLAKMHSSAKKSDFNSQLAVHKLAKSIPLRRQVTVSVDSSSSMHSGGMLVRPSRLSSSGSPMLSGVSEYELPQDPRWEVQRDRLVLGKPLGEGCFGQVMMAEAMGMDKEKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKIIGKHKNIINLLGACTQDGPLYVIVEFAAKGNLREYLRVRRPPGMEYCYNPDQVPVENMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDRPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDLDRTLSMTSNQEYLDLSVSLDQFSPNFPDTRSSTCSSGEDSVFSHDAGADEPCLPKFPPHPNRGVAFKKR
Protein: Pre-mRNA-splicing factor SYF2 (PRP19 complex protein 31) (Synthetic lethal with CDC40 protein 2) (P53277)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing and cell cycle control. As a component of the NTC complex (or PRP19-associated complex), associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. The cell cycle arrest of SYF2 defective cells may be due to the inefficient splicing of TUB1.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-splicing factor CEF1
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor NTC20
- Pre-mRNA-splicing factor PRP46
- Pre-mRNA-splicing factor ISY1
- Pre-mRNA-splicing factor SLT11
- Pre-mRNA-splicing factor SNT309
- Pre-mRNA-splicing factor CLF1
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor CWC2
Sequence:
MDFYKLDEKLKELKRKRVDVSIKSRKLADREIQEVSANRKPRVYSMEDVNDADESVGDTESPEKEKAFHYTVQEYDAWERRHPQGKTGQSQRGGISYDQLAKLSYEKTLRNLATQTQNSSKQDSSADEEDNKNVPKKGRIGKVQKDTKTGKITIADDDKLVNKLAVSLQSESKKRYEARKRQMQNAKTLYGVESFINDKNKQFNEKLSRESKGSE
Protein: F28J7.6 protein (F28J7.6/F28J7.6) (F4P13.28 protein) (Transmembrane protein) (Q9S7S5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Hydroxyproline-rich glycoprotein family protein
- Serpin-Z10
- Peroxidase 35
- CHP-rich zinc finger protein-like
- Cysteine/Histidine-rich C1 domain family protein
- Rop guanine nucleotide exchange factor 4
- At4g23490/F16G20_190
- Trichohyalin
- At1g22850/F29G20_19
- Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger domain-containing protein
Sequence:
MRAFSLMICVLVLATLIMVAESKSSYSGNDETLTPPPPMAPSPSPTGTDGGHFGEPKTLLPPPNAATFTTCPLLITSTLISALAFVF
Protein: Exosome complex component CSL4 (Exosome component 1) (Q9Y3B2)
Organism: Homo sapiens (Human)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}.
Interaction partners:
- Exosome complex component RRP4
- Exosome complex component RRP40
- M-phase phosphoprotein 6
- Nuclear nucleic acid-binding protein C1D
- Exosome complex component RRP45
- Exosome complex component 10
- Exosome complex exonuclease RRP44
- Exosome complex component RRP46
- Exosome complex component MTR3
- Exosome complex component RRP43
Sequence:
MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT
Protein: General transcription and DNA repair factor IIH subunit TFB5 (B7Z018)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368032}.
Interaction partners:
- General transcription factor IIH subunit 4
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIH subunit
- General transcription factor IIH subunit 3
- General transcription factor IIE subunit 1
- CDK-activating kinase assembly factor MAT1
- Transcription initiation factor IIE subunit beta
- General transcription factor IIH subunit 1
- Cyclin-H
Sequence:
MVNVMKGVLVECDPAMKQFLLHLDEKLALGRKFIIQDLDENHLFISTDIVEVLQARVDDLMDRISFPLHDKDA
Protein: Carboxylesterase 1 (H3BQV8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
KELIPEATEKYLGGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHREGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKEVAFWTNLFAKKAVEKPPQTEHIEL
Protein: Heat shock factor C2a (A0A024DAP6)
Organism: Triticum aestivum (Wheat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Uncharacterized protein
- Heat shock factor binding protein
- Heat shock factor binding protein
- Heat shock factor binding protein
- Heat shock factor binding protein
- Heat shock protein 90
- Endoplasmin homolog
- Endoplasmin homolog
- Endoplasmin homolog
- SH3 domain-containing protein
Sequence:
MAAASVGGGAAPFVWKTYRMVEDPGTDGVIGWGKGNNSFVVADPFVFSQTMLPAHFKHNNFSSFVRQLNTYGFRKVDPDRWEFAHGSFLRGQTHLLRNIVRRGTPAPGGGGKRKDAGAAGLTDDDMTMVATEVVRLKKEQSTIDDRVAAMWRRVQETERKPKQMLAFLLTIVGDRDTLQRLVGNSGNAAGGDQEPVEGGEKRARLLLDGDFGNVSAFGPDAVDFAGFYTDDAFANAPVPVEAAAGSGGGGAGCTFAFGVDSGY
Protein: Transcription factor iws1 (O42964)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
Interaction partners:
- Transcription elongation factor spt6
- Transcription elongation factor spt5
- Transcription elongation factor spt4
- DNA-directed RNA polymerase II subunit rpb1
- Tetratricopeptide repeat protein 1
- FACT complex subunit pob3
- Uncharacterized protein C13E7.08c
- FACT complex subunit spt16
- RNA polymerase-associated protein C651.09c
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MSEEEKAELENMQVESEAKTSENDQTIDTKVDVADVTTHVDEDLDNKEEALDFSEDELSDLDENQFENFDESKIGREAEEPTIYNLPTFKKKQEPNTIEENLEVPRKVRKEQKPRRRRGKRSSTVDALNDELNELGENEEEVLTEQKQLDPTLAAKKELDLQMDAVLKPTRTKKRSNEDNLEQMADDEVLRLREQMRLAALRDAELNSEQLPATEKLKMLPLVDAVLRKTHLYDTILDNNVLDSVRMWLEPLPDRSLPALNIQRSLMDILTKLPIQTEHLRESKIGRIVLFYTISKKPEPFIKRIADNLVSEWSRPIIKRSANYRDRAVGVASFNPEVFQTRRRRDLAAAESNDDAQASRTGRTVIPRSIDSRYQVAPRVRLNPTAMTIAGRMKPADTEQVRKLKAKMKAIRSKSSKKSGVSIEGRGL
Protein: Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) (Q9Y2L5)
Organism: Homo sapiens (Human)
Function: Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy.
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000250}.
Interaction partners:
- Trafficking protein particle complex subunit 3
- Trafficking protein particle complex subunit 12
- Trafficking protein particle complex subunit 11
- Trafficking protein particle complex subunit 2
- Trafficking protein particle complex subunit 1
- Trafficking protein particle complex subunit 4
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 6A
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit 2-like protein
Sequence:
MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYSYPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGLLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPYPAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAEDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKFHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTFGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNLSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV
Protein: Histone deacetylase 6, isoform E (EC 3.5.1.98) (M9NGF7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MASKSKTGTTGAATAAGGTGSSSGSISGGFNAADPRKSNKPNAALLEAKRRARNNMLKNQGCGSQESVTDIFQNAVNSKSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKEEDLHTVLRHWIGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGRRLPRDPVVGENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGDERPSGSKPKVKVKTLSDYLAENKEALEQSEMFAVYPLKTCPHLRLLRPEEAPRSLDSGAECSVCGSTGENWVCLSCRHVACGRYVNAHMEQHSVEEQHPLAMSTADLSVWCYACSAYVDHPRLYAYLNPLHEDKFQEPMAWTHGCAWREDGCYATGPDGRDEDDDDDNGAGSSICLRLERNN
Protein: Yuri gagarin, isoform R (A0A0U1QT60)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNTGNSSTDCPHRQQLEHTLLHCQTESDLLQATRDNYLSIIDEFKRDLEELTEQVEQQQQQLQQSSLASQSCPEPELHFVDQSRINCELEIQNGQLSCQIKGLQENLKDRDNQISQLQSMINSYSDFSENNRLKEEMHVLKQKNCDLSRQLRDLPSLLKNQENQSVELCTKYESLMASFEDQCQELKDAKRKAQSLQTRLDQVEQLQDELRTERKILREEVVALKEKEAVSSGRERALQDQQKSAQLEMEKMRTLVRKMQSHLQLDDIRHRESIQRMNETTESLREELRTISENCQQMQIRLNQQTEVNQQQEQIIDSFRKWKDAQVRADEAMRLCAKRAEEHIHMLLDENRTLAEDYRNLFRDYKLLETEIKRVKQAVNCASSSAISCPPPKSGGLTNPEAGNDMARRLQNLTSTSQRIFNQNQTMNDQYCNSLISGSPAGIGQPVAQSILRRTRSSQDQS
Protein: Kinesin family member 21A (H0YHT2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIPVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLKQREELTKRREKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQANIMQMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSVPLENVEDSTDEDAPLNSPGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSELASDTSTGDASLPGPLTPVAEGQEIGMNTETSGTSAREKELSPPPGLPSKIGSISRQSSLSEKKIPEPSPVTRRKAYEKAEKSKAKEQKQSDESDSSLSEVHRGIINPFPASKGIRAFPLQCIHIAEGHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQEIMSLGGHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRDSAKCIRTLTSSGQVTLGDACSASTSRTVAIPSGENQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISSGQDLIITGSKDHYIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLTQKDLLQQVPNAHKDWVCALGVVPDHPVLLSGCRGGILKVWNMDTFMPVGEMKGHDSPINAICVNSTHIFTAADDRTVRIWKARNLQDGQISDTGDLGEDIASN
Protein: Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) (Q6PJG6)
Organism: Homo sapiens (Human)
Function: Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors.
Subcellular location: Nucleus {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:39032489}. Cytoplasm {ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:39032489}. Note=Present at double strand breaks (DSBs)following ionizing radiation treatment. The ubiquitinated form localizes in the nucleus in a NDFIP1-dependent manner. {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:25631046}.
Interaction partners:
- Breast cancer type 1 susceptibility protein
- Transcription factor E4F1
Sequence:
MDPECAQLLPALCAVLVDPRQPVADDTCLEKLLDWFKTVTEGESSVVLLQEHPCLVELLSHVLKVQDLSSGVLSFSLRLAGTFAAQENCFQYLQQGELLPGLFGEPGPLGRATWAVPTVRSGWIQGLRSLAQHPSALRFLADHGAVDTIFSLQGDSSLFVASAASQLLVHVLALSMRGGAEGQPCLPGGDWPACAQKIMDHVEESLCSAATPKVTQALNVLTTTFGRCQSPWTEALWVRLSPRVACLLERDPIPAAHSFVDLLLCVARSPVFSSSDGSLWETVARALSCLGPTHMGPLALGILKLEHCPQALRTQAFQVLLQPLACVLKATVQAPGPPGLLDGTADDATTVDTLLASKSSCAGLLCRTLAHLEELQPLPQRPSPWPQASLLGATVTVLRLCDGSAAPASSVGGHLCGTLAGCVRVQRAALDFLGTLSQGTGPQELVTQALAVLLECLESPGSSPTVLKKAFQATLRWLLSSPKTPGCSDLGPLIPQFLRELFPVLQKRLCHPCWEVRDSALEFLTQLSRHWGGQADFRCALLASEVPQLALQLLQDPESYVRASAVTAMGQLSSQGLHAPTSPEHAEARQSLFLELLHILSVDSEGFPRRAVMQVFTEWLRDGHADAAQDTEQFVATVLQAASRDLDWEVRAQGLELALVFLGQTLGPPRTHCPYAVALPEVAPAQPLTEALRALCHVGLFDFAFCALFDCDRPVAQKSCDLLLFLRDKIASYSSLREARGSPNTASAEATLPRWRAGEQAQPPGDQEPEAVLAMLRSLDLEGLRSTLAESSDHVEKSPQSLLQDMLATGGFLQGDEADCY
Protein: Uncharacterized protein (Q389N2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MASLRKKLDSFRVDVGDRPRLGEENGAFTPTKTLCCNRSASKPLPFILFPSVRCCCCQTSEVKPMSDLSPRFRVPSGVGPQQGGSCQSTFTGEEEGGECVEGAASSKGAQINCGCCVPNASLESADGSLLDVVDLLTTFYNLPPPACWRCRETLPNSFGEELLASALGTTSDNLLDRYASLLVERLNKSVIGIETPKHTERKLSVLRTEGTTTSVDALAHLPYSVLGKVLENTGFPNEIMPYKIACAACELHFTDRTGDCVRFASASRHTGSVSHTSTRVDKPESVPDSNCTCKEGAIESLLCSVRFLWLPARFLESELRRYEVLLPTIRGRCCATYSGFLLRLGQAAKLKSCLRSSPDSETGPFQDGPFSDILLSELRRLRPSYDFLTTAERHLVLGENVTFSLLRKIQEKCDASE