wanglab/gogpt-training-data huggingface dataset:
Protein: Thioredoxin H3 (AtTrxh3) (Thioredoxin 3) (AtTRX3) (Q42403)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiol-disulfide oxidoreductase that possesses disulfide reductase and insulin disulfide bonds reducing activities. Heat shock causes oligomerization and formation of high molecular weight (HMW) complexes with concomitant functional switching from a disulfide reductase to chaperone.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19339505}.
Interaction partners:
- NADPH-dependent thioredoxin reductase 3
- Probable glycosyltransferase At5g25310
- Thioredoxin reductase 1, mitochondrial
Sequence:
MAAEGEVIACHTVEDWTEKLKAANESKKLIVIDFTATWCPPCRFIAPVFADLAKKHLDVVFFKVDVDELNTVAEEFKVQAMPTFIFMKEGEIKETVVGAAKEEIIANLEKHKTVVAAA
Protein: Calnexin (P35564)
Organism: Mus musculus (Mouse)
Function: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:7628443}; Single-pass type I membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:P24643}; Single-pass type I membrane protein {ECO:0000255}. Melanosome membrane {ECO:0000250|UniProtKB:P27824}; Single-pass type I membrane protein {ECO:0000255}. Note=The palmitoylated form preferentially localizes to the perinuclear rough ER (By similarity). When bound to CD3 epsilon chains, calnexin's ER retention signal can be masked, permitting it to escape ER retention (By similarity). Localizes to endoplasmic reticulum mitochondria-associated membrane (MAMs) that connect the endoplasmic reticulum and the mitochondria (By similarity). {ECO:0000250|UniProtKB:P24643, ECO:0000250|UniProtKB:P27824}.
Interaction partners:
- Protein disulfide-isomerase A3
- Calreticulin
- Tapasin
- Calreticulin
- Endoplasmic reticulum chaperone BiP
- Endoplasmin
- Beta-2-microglobulin
- ER degradation-enhancing alpha-mannosidase-like protein 1
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- UDP-glucose:glycoprotein glucosyltransferase 1
Sequence:
MEGKWLLCLLLVLGTAAVEAHDGHDDDAIDIEDDLDDVIEEVEDSKSKSDASTPPSPKVTYKAPVPTGEVYFADSFDRGSLSGWILSKAKKDDTDDEIAKYDGKWEVDEMKETKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTAELSLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGVYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIADPDAVKPDDWDEDAPSKIPDEEATKPEGWLDDEPEYIPDPDAEKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPMIDNPNYKGKWKPPMIDNPNYQGIWKPRKIPNPDFFEDLEPFKMTPFSAIGLELWSMTSDIFFDNFIISGDRRVVDDWANDGWGLKKAADGAAEPGVVLQMLEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQSNAMEYKKTDAPQPDVKDEEGKEEEKNKRDEEEEEEKLEEKQKSDAEEDGVTGSQDEEDSKPKAEEDEILNRSPRNRKPRRE
Protein: Transcriptional regulator FurA (P9WN87)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox-dependent manner.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Catalase-peroxidase
- Zinc uptake regulation protein
- Alkyl hydroperoxide reductase C
- DUF4262 domain-containing protein
Sequence:
MSSIPDYAEQLRTADLRVTRPRVAVLEAVNAHPHADTETIFGAVRFALPDVSRQAVYDVLHALTAAGLVRKIQPSGSVARYESRVGDNHHHIVCRSCGVIADVDCAVGEAPCLTASDHNGFLLDEAEVIYWGLCPDCSISDTSRSHP
Protein: Synapsin-1 (Brain protein 4.1) (Synapsin I) (P17600)
Organism: Homo sapiens (Human)
Function: Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity).
Subcellular location: Synapse {ECO:0000250|UniProtKB:O88935}. Golgi apparatus {ECO:0000250|UniProtKB:O88935}. Presynapse {ECO:0000269|PubMed:21441247}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:P09951}. Note=Dissociates from synaptic vesicles and redistributes into the axon during action potential firing, in a step that precedes fusion of vesicles with the plasma membrane. Reclusters to presynapses after the cessation of synaptic activity. {ECO:0000250|UniProtKB:P09951}.
Interaction partners:
- Synaptophysin
- Ras-related protein Rab-3A
- Synaptosomal-associated protein 25
- Vesicle-associated membrane protein 2
- Disks large homolog 4
- Synaptotagmin-1
- Neuromodulin
- Regulating synaptic membrane exocytosis protein 1
- Vesicular glutamate transporter 1
- DnaJ homolog subfamily C member 5
Sequence:
MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPGAHSPGATPGPGTATAERSSGVAPAASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAASRVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD
Protein: LOB domain-containing protein 16 (ASYMMETRIC LEAVES 2-like protein 18) (AS2-like protein 18) (Q9SLB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator. Involved in lateral root formation. Regulated by the transcriptional activators ARF7 and ARF19. Functions in the initiation and emergence of lateral roots, in conjunction with LBD18, downstream of ARF7 and ARF19. Acts downstream of the auxin influx carriers AUX1 and LAX1 in the regulation of lateral root initiation and development.
Subcellular location: Nucleus {ECO:0000269|PubMed:17259263}.
Interaction partners:
- Auxin response factor 7
- Auxin response factor 19
- WUSCHEL-related homeobox 11
- WUSCHEL-related homeobox 12
- Auxin-responsive protein IAA14
- Ethylene-responsive transcription factor ERF086
- WUSCHEL-related homeobox 5
- GATA transcription factor 23
- Probable transcription factor PosF21
- Histone-lysine N-methyltransferase ATXR2
Sequence:
MASSGNGTTAGTGSPCGACKFLRRKCASDCIFAPYFSSEQGAARFAAIHKVFGASNVSKLLLNVPIHDRCEAVVTIAYEAQARLHDPVYGCVSHIFALQQQVAFLQSQVMQMKAQIAGHQTSAAGDLRHSSESTNQFMTWQQTSVSPIGSAYSTPYNHHQPYYGHVNPNNPVSPQSSLEESFSNTSSDVTTTANVRETHHQTGGGVYGHDGIGFHEGYPNKKRSVSYCSSDLGELQALALRMMKN
Protein: FI14518p (Pxb, isoform B) (Pxb, isoform C) (Transmembrane protein Pxb) (Q8MY02)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWKMLDMMELSEAELFMFDCDDCSGTPLAPPPQFLIPPPPRPPALAEFTVVPQDCNEEQLAQQQWESDVCQAMPILDASLYSSQSLATSAMIAVFSLLLVLIVLISSLFVWKNKRKVQNLLPCKTPTRGPLNGAMPLGGGTLGSAHHHHHHGMYEDPDAHLGHHRPLVMHRHHHHQQLAHHHHYQQHHSELLQGKSIHYPSGYPMTRSPPFLVSSSPGPDPYRSNDNVYEELGPGRVDSDGESEPPLHSDDDFAEDELSLPGECSFQKETNLPAAAGATPYHERAAGSSSSGTGVAGVAGATGSVATSASLPQAVQERHSVLSSGSSMGQDTSTATASSASNNNHELASGSNNRRTGRTRQSRSSQDQDLNNSTSTADIADLAPLYDNRSNLMSLGYVARSTAPQFYNTLEHEVERRNRINAQLSKAPVPPLSTIYRERIRYPHASQQYPSSVASGLMAATMRARTQPRVLDRRLAPHQHQHHRIHAAPMAQEPSYCYAEPMYNANYYYESAGGARPYASTLLPTAADYRHPYGDSSFGSDSGYSHHTPASSIGRQDYDVAEPQVLTQPKPSKLSSALNFSWNRNSRSKGTSGGAIAKTSGNSSNSSATSPNNNSSACSTVTSQLENNNTASLSPA
Protein: ADP ribosylation factor like GTPase 1 (ADP-ribosylation factor-like protein 1) (Q52NJ5)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELRKAILVVFANKQDMEQAMTPSEMANSLGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSRQ
Protein: Probable conserved membrane protein (P71799)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Alpha-pyrone synthesis polyketide synthase-like Pks18
- Possible oxygenase
- Glycolipid sulfotransferase Rv1373
- HTH cro/C1-type domain-containing protein
- nitric oxide dioxygenase
- Geranylgeranyl diphosphate synthase
- Putative diacylated glycolipid transporter LprF
- Chaperone protein DnaJ 2
- Chaperone protein DnaJ 1
- Possible transcriptional regulatory protein
Sequence:
MTNDLPDVRERDGGPRPAPPAGGPRLSDVWVYNGRAYDLSEWISKHPGGAFFIGRTKNRDITAIVKSYHRDPAIVERILQRRYALGRDATPRDIHPKHNAPAFLFKDDFNSWRDTPKYRFDDPNDLLHRVKARLAEPALAARIKRMDTLFNAIVAVLAVGYFAVQGVRLVEPSWMPLWAFVIAMVLLRSSLAGFGHYALHRAQRGLNRVFNNAFDLNYVALSLVTADGHTLLHHPYTQSEVDIKKNVFTMMMRLPWLYRVPVHTIHKFGHMLSGMAIRIVDVFRITRKVGVEESYGSWRAALPHFLGSAGVRLLLVSELVVFAIAGDFWPWALQFVATLWVSTFLVVASHEFEDDTQGGAVNGEDWGIDQLEHANDLTVIGNRYVDCFLSAGLSSHRVHHVLPFQRSGFANIVTEDVLREEAAKFGVEWLPAKGFITDRLPRLCRKYLLTPSRQAKERHWGFVREHCSPAALKASASYVVAGFVGIGSV
Protein: Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (P48450)
Organism: Rattus norvegicus (Rat)
Function: Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P48449}; Peripheral membrane protein {ECO:0000250|UniProtKB:P48449}.
Interaction partners:
- Squalene monooxygenase
- Lanosterol 14-alpha demethylase
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Lathosterol oxidase
- Delta
- Ergosterol biosynthesis 28 homolog
- Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
- Methylsterol monooxygenase 1
- Squalene synthase
- Diphosphomevalonate decarboxylase
Sequence:
MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLDTTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRFSSLYPDNTLAGHI
Protein: Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56) (Q8K057)
Organism: Mus musculus (Mouse)
Function: Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Note=Basal body and ciliary axoneme in the chondrocytic ATDC-5 cell line.
Interaction partners:
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 172 homolog
- TRAF3-interacting protein 1
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 20 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 56
Sequence:
MRLKISLSKEPKHQELVSCVGWTTAEELYSCSDDHQIVKWNLLTSETSLIVKLPDDIYPIDLHWFPKSLGIKKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQVKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRVLYGSQPHEHPITSVAWAPDGELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVVFAHVVEQRWEWKNFQVTLTKRRTMQVRNVLNDAVDLLEFRDRVIKASLNHAHLVVSTSLQCYVFSTKNWNTPLIFDLKEGTVSLILQAERHFLLVDGGGIYLHSYEGRFISSPKFPGMRTDILNAQTVSLSNDTIAIKDKADEKIIFLFEASTGKPLGDGKLLSHKNEISEIALDQKGLTNDRKIAFIDKNRDLYITSVKRFGKEEQIIKLGTMVHTLAWCDTCNILCGIQDTRFTVWYYPNTIYVDRDILPKTLYERDASEYSKNPHIVSFVGNQVTIRRADGSLVHISISPYPAILHEYVSSSKWEEAVRLCRFVKEQSMWACLAAMAVANRDMVTAEIAYAAVGEIDKVRYINAIKDLPSRESKMAHILMFSGNIQEAETVLLQAGLVYQAIQININLYNWERALELAVKYKTHVDTVLAYRQKFLDTFGKQETNKRYLQYAEGLQIDWEKIKAKIEMEITKERDRSSSGQSSKSVGLKH
Protein: ESX-3 secretion system protein EccA3 (ESX conserved component A3) (Type VII secretion system protein EccA3) (T7SS protein EccA3) (P9WPI3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:B2HSU9}.
Interaction partners:
- ESX-3 secretion system ATPase EccB3
- ESX-3 secretion system protein EccC3
- ESX-3 secretion system protein EccE3
- ESX-3 secretion system protein EccD3
- PPE family protein PPE4
- Mycosin-3
- Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0281
- ESX-3 secretion-associated protein EspG3
- PE family immunomodulator PE5
- Uncharacterized PPE family protein PPE3
Sequence:
MAGVGEGDSGGVERDDIGMVAASPVASRVNGKVDADVVGRFATCCRALGIAVYQRKRPPDLAAARSGFAALTRVAHDQCDAWTGLAAAGDQSIGVLEAASRTATTAGVLQRQVELADNALGFLYDTGLYLRFRATGPDDFHLAYAAALASTGGPEEFAKANHVVSGITERRAGWRAARWLAVVINYRAERWSDVVKLLTPMVNDPDLDEAFSHAAKITLGTALARLGMFAPALSYLEEPDGPVAVAAVDGALAKALVLRAHVDEESASEVLQDLYAAHPENEQVEQALSDTSFGIVTTTAGRIEARTDPWDPATEPGAEDFVDPAAHERKAALLHEAELQLAEFIGLDEVKRQVSRLKSSVAMELVRKQRGLTVAQRTHHLVFAGPPGTGKTTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTRNIDFPSYTSHELVEIAHKMAEQRDSVFEQSALHDLEALFAKLAAESTPDTNGISRRSLDIAGNGRFVRNIVERSEEEREFRLDHSEHAGSGEFSDEELMTITADDVGRSVEPLLRGLGLSVRA
Protein: Uncharacterized protein (Q382X4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFCNLNVCLAFLSSQYGKENMNARKPLAVSAGTNSRSGEGDWKSTMRSFREGVRCLGEENEALRTVRSDLDAISRKLTEKMNSLVEENGSFHKSMSTLLDDERRKVSIITDQNENLLHKLEELRKEYDDANKEISRLTDLVHTEKSRNNSVVGLFEKKLAEKEDEYQTELRLREQSLEKLKTQLEEKCSAYEAQLTDRDNLLQTERCQWKLQKEVYEKEIERLLSQVGKFAITQRSSSQQSTLGVDVAHAKPPLAPVPPPAPTDEEGDRAVVKKRRLEAVRQQRRLKENDKNDTTLASIGKLKDLKESLQL
Protein: Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) (Q9EPE9)
Organism: Mus musculus (Mouse)
Function: Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29505581}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HD20}.
Interaction partners:
Sequence:
MAVVGNAVPCGARPGGARDNGSPQPGSRLRPGLAAGPALIANGDELVAAVWPYRRLALLRRLTVLPFAGLLYPAWLGAAASGCWGWGSSWTQIPEAALLALATICLAHALTVLSGHWSVHAHCALTCTPEYDPNKVTFVKVVPTPNNGSTELVALHRDKGEDGLEVLSFEFQKIKYSYDALEKKQFLPVAFPVGNAFSYYQSNRGFQEDSEIRAAEKKFGSNKAEMVVPDFSELFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEASLVQQQMRNMSEIRKMGNKPHMIQVYRSRKWRPVASDDIVPGDIVSIGRSPQENLVPCDVLLLRGRCIVDEAMLTGESVPQMKEPIEDLSPDRVLDLQADARLHVIFGGTKVVQHIPPQKATSGLKPVDNGCVAFVLRTGFNTSQGRLLRTILFGVKRVTANNLETFIFILFLLVFAIAAAAYVWVEGTKDPSRNRYKLFLECTLILTSVVPPELPIELSLAVNTSLIALAKLYMYCTEPFRIPFAGKVEVCCFDKTGTLTSDSLVVRGVAGLRDGKEVTPVSSIPIETHRALASCHSLMQLDDGTLVGDPLEKAMLTAVDWTLTKDEKVFPRSIKTQGLKIHQRFHFASALKRMSVLASYEKLGSTDLCYIAAVKGAPETLHSMFSQCPPDYHHIHTEISREGARVLALGYKELGHLTHQQAREIKREALECSLKFVGFIVVSCPLKADSKAVIREIQNASHRVVMITGDNPLTACHVAQELHFIDKAHTLILHPPSEKGQPCEWRSIDSSIVLPLTLGSPKALALEHALCLTGDGLAHLQAVDPQQLLCLIPHVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLANAPERVVERRRRPRDSPVLSNSGPRVSRSTKQKSALLSPEEPPASHRDRLSQVLRDLEEESTPIVKLGDASIAAPFTSKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAYSQSVLYLEGVKFSDFQATLQGLLLAGCFLFISRSKPLKTLSRERPLPNIFNLYTILTVMLQFSVHFLSLVYLYREAQARSPEKQEQFVDLYKEFEPSLVNSTVYIMAMAMQMATFAINYKGPPFMESLPENKPLVWSLAVSLLAIIGLLLGSSPDFNSQFGLVDIPVEFKLVIGQVLALDFCLALLADRVLQFFLGTPKLRVPS
Protein: COMPASS component BRE2 (Brefeldin-A sensitivity protein 2) (COMPASS protein 60) (Complex proteins associated with SET1 protein BRE2) (Set1C component BRE2) (P43132)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
Subcellular location: Nucleus {ECO:0000305}. Chromosome, telomere {ECO:0000305}.
Interaction partners:
- COMPASS component SPP1
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- COMPASS component SDC1
- COMPASS component SHG1
- COMPASS component SWD3
- COMPASS component SWD2
- COMPASS component SWD1
- Histone H3
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin
Sequence:
MKLGIIPYQEGTDIVYKNALQGQQEGKRPNLPQMEATHQIKSSVQGTSYEFVRTEDIPLNRRHFVYRPCSANPFFTILGYGCTEYPFDHSGMSVMDRSEGLSISRDGNDLVSVPDQYGWRTARSDVCIKEGMTYWEVEVIRGGNKKFADGVNNKENADDSVDEVQSGIYEKMHKQVNDTPHLRFGVCRREASLEAPVGFDVYGYGIRDISLESIHEGKLNCVLENGSPLKEGDKIGFLLSLPSIHTQIKQAKEFTKRRIFALNSHMDTMNEPWREDAENGPSRKKLKQETTNKEFQRALLEDIEYNDVVRDQIAIRYKNQLFFEATDYVKTTKPEYYSSDKRERQDYYQLEDSYLAIFQNGKYLGKAFENLKPLLPPFSELQYNEKFYLGYWQHGEARDESNDKNTTSAKKKKQQQKKKKGLILRNKYVNNNKLGYYPTISCFNGGTARIISEEDKLEYLDQIRSAYCVDGNSKVNTLDTLYKEQIAEDIVWDIIDELEQIALQQ
Protein: C-module-binding factor A (O97101)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Transcriptional regulator involved in phagocytosis and pinocytosis. Both activates and represses transcription. Regulates expression of acaA, carA, pkaC, csaA, cotB and lagC. Promotes amplification of the tRNA gene-associated retrotransposon TRE5-A, a mobile genetic element formerly called as Dictyostelium repetitive element (DRE). Suppresses agnC and agnE encoding argonaute proteins which are part of a RNA interference pathway controlling TRE5-A amplification. Required for amplification of both sense and antisense RNA transcripts, but does not activate their promoters found in A-module and C-module of the TRE5-A, respectively. Nevertheless, binds to distinct DNA sequences containing A and T stretches within the C-module in vitro.
Subcellular location: Nucleus {ECO:0000269|PubMed:10491202, ECO:0000269|PubMed:11162086, ECO:0000269|PubMed:16607013, ECO:0000269|PubMed:19343174, ECO:0000269|PubMed:8898890}.
Interaction partners:
- Argonaut-like protein
Sequence:
MEELIKAPNSNFIIMSNQPYQTTSPEIVEDYIIKRGQPFVLTGTTQGWSRSNMFTLDFLSERYSEMELINSPRNNETHTDLQGWRMKDFISYLQVSPEERNPKHLYGKDIACPREWQEYLSHKLQPQYSYKSRFDLVSHLPDYLQPETLLVYIGSNGTYTPGHIDMCGSLSQNLMVSSDQDAFAWWFIVPTEYKDEALKFWGDKGGDVYNESRFIRPIDLLGAPFPIYVFKQRPGDFIFVPPDSVHQVVNCGPGISTKVAWNSISLKSLPISYFSSLPHTRRMAKPELFRIKAIAYYTLRKIMGDVENTNFNTIDVNDVIDIIAPLLEIFHNILQTESILIPKPNYPYCNGETIPFLQPFKYFNGDRIQDRRCDHCNSDIFNRCYHCETCKTDDGQGKDFCFDCVSSGIGCEFHFKVMVLKEFISHSKLKKELSSFYEIYKNLLAHSGRRPKEVDDIITKSTDRVSDECGFLTTATVAYHVVFYSSQKKIKCHRCEKRFKKFSIIFCTNCNARFCEQCVVNTFGQNFQVLMKRNEWECFCCKGLCDCSNCTSNSNSSNHPRILNNNQQLGLPYNNNNNSNNNNNNNINNNNNNNNNNINNNNNNMNNNNSINNNNNNNNNNNINNNNINNNNHHNNNGNNNLNSSYSSLNALSSLSQQQSYGSYDNYNNNNNNNNYNNNNNNNGHIQILKSGRQYDDEQSSSSGSGSSNSTPTKPRPRNGGDDGLMSHFSGNNNNNNNHHNNNNNNNNNHHMMSHHHHNNNNNNNNNNNPTTSSLSSLSTSLSSSSTSTQKPMDVHSKKRPIVLDNDKPKGRPPKNLKEWTSTHKFIISLIELFRSSNNAILGKPNPHYKPIENLPPLVQLYLSQRKAFGGVLWAKTNSCPLLPCIWVKDLSVIPPNTKLLPSLIQGKKIVVLFFGDQDQEEYVGIVGKKSIFSFDEVNQTLLLKCGEVPLAQLEDLFNTTEPEIAMKKDIAAFNYKNQIEEKEEGLYVKQELYNNKKII
Protein: Probable receptor-like protein kinase At5g38990 (EC 2.7.11.-) (Q9FID9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Receptor-like protein 45
- Probable disease resistance protein At4g19530
- Receptor-like protein 14
- Cyclase-associated protein 1
- Disease resistance protein RPS4B
- Receptor like protein 21
- GPI-anchored protein LLG3
- GPI-anchored protein LLG2
Sequence:
MICHVLVIFTILVSAVVDATASYEPTDVFLINCGDTSNNMDYSGRNWTTENPKFMSSNAVDDASFTSSASYQESGIPQVPYLKARIFRYDFTYSFPVSPGWKFLRLYFYPTRYGSDFDAVKSFFSVNVNRFTLLHNFSVKASIPESSSLIKEFIVPVNQTLDLTFTPSPNSLAFVNGIEIISMPDRFYSKGGFDDVVRNVGRDVDFEIDNSTAFETVYRVNVGGKVVGDVGDSGMFRRWLSDEGFLLGINSGAIPNITGVKINYTDKTPAYVAPEDVYTTCRLMGNKDSPELNLNFNLTWLFEVDAGFAYIVRLHFCETQPEVNKTGDRVFSIFFGYQLAMREMDVFRLSGGFRLPMYLDFKVLVDADGTSQRPSLRVDLTPYKEDYPTYYDAILSGVEILKLSNSDGNLAGLNPIPQLSPPPQSITPLKGKGKSSHVLPIIIAVVGSAVALAFFVLVVVLVVMKRKKKSNESSVDTTNKPSTNSSWGPLLHGTGSTNTKSASSLPSDLCRRFSIYEIKSATNDFEEKLIIGVGGFGSVYKGRIDGGATLVAVKRLEITSNQGAKEFDTELEMLSKLRHVHLVSLIGYCDDDNEMVLVYEYMPHGTLKDHLFRRDKASDPPLSWKRRLEICIGAARGLQYLHTGAKYTIIHRDIKTTNILLDENFVAKVSDFGLSRVGPTSASQTHVSTVVKGTFGYLDPEYYRRQILTEKSDVYSFGVVLLEVLCCRPIRMQSVPPEQADLIRWVKSNFNKRTVDQIIDSDLTADITSTSMEKFCEIAIRCVQDRGMERPPMNDVVWALEFALQLHETAKKKNDNVESLDLMPSGEVGTTTDGEDDLFSRTTGHVGKSTTTDDSVLVVGDERSGSSWGVFSEINEPKAR
Protein: Flocculation protein (DUF1296) (Q0WUY5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RAF-like serine/threonine-protein kinase 20
- Probable protein phosphatase 2C 51
Sequence:
MVGSGARVSISATTRKMIQNIKETTAGNYSEDEIIAMLHECNMDPDETAQRLLLQDPFHEVKKKRDKRKENINNKDSAESQWRSGGGGRGSRGGRMNFSSRHASNDVAGAKNSFKKENGPKQVIDPSTSTSQEIKTKDIALVSSHSAVMDKSTVGPKSGSSDVRQSSNLPAGSGQLKAGRSSVPSNNIDGAPSSVELSKNRVAVGSRVVHTEQKAVDSLPLPRPSSSEVRFTSSNPKSEQTAPEQHIGESKSHTRSRGVGKTAVNDTYGSRPASSHSNSTGSRPSSNYSNRSHQTVGPQRGAGSIKEWKPKPVVNHNTTQGSGASSTGETLAVPTEASDKSVEDATPSAEATSRLQRQLEDLQIQRQHVIIPNHILVPEAERTKLSFGSFDADFSITSSTVAFPQSEKRSAPLSHNSQEVEESFAEEEFRHPTVHSIEKEEDGNVYSESPSQVPDNMAGEGNTATNTAPEYDVTKQENMLESESNQNSFDQVPSNIIGIVPPAPGNQHPQFETSDPQARDALRLPSFMGQQPFDTASYYAQFYRSGPDSDGRVSPFVSPGVASKFNGITVLPPHSSQTMQEGGNNLVLSTASPPPLVTQAAGLMQSSIPVTQQPVPVFRPPGLHMSHYPPNYVPYGYFSPFYLPPPTMHQYLSNGAYAQQPQASGVYPPPPGTATGGKYTLPHYKPGTNTGNMTHVGITGGYGPTYGSFPAGYNPTSAASAGNSTSNEDLNSLQLKENNGYSTTGQQSEALPVWITGPGRDVPSSFYGLQHHGQHVTYAPAQAGHVAFPGMYHPGQAVTATGVHHPLLQQSQGVAGAEMVAPAPNVFQQPQQTQMNWPSNY
Protein: Probable alpha-1,2-galactosyltransferase gmh1 (EC 2.4.1.-) (Q09679)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein C5H10.12c
- Meiotically up-regulated gene 136 protein
- Uncharacterized protein C4C3.09
Sequence:
MLSFFTKNTLTKRKLIMLALAIVFTFFAFGLYFIPHDEISVFDFKLPALQYETTVTSLDNFLIGGSTTLYTATVNHEDLNEPKSHEIVMLLASDGNVGSFESNLLDDCFKNRIEYAKLQNYNFEFVNVSSLVVPPVWGKMPAILQTMRKYPSAKWIWWLDQDALIMNKNLSLQELFLSPAMLQKSLLREQPIINSFGEDNFRITPAAYSKEMIEQIQFLISQDHNGLNAGSFLVRNSRSIALLMDLLTDPSLADAGVVRHEQDLIGYFIQKHSQVASMVGILPQRFINAFHEGPPTMQWQEGDLALHFAGCWVENKCAELWTKYKDKII
Protein: LOC792194 protein (Snail family zinc finger 1b) (B3DH44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Sna-1 protein
- Forkhead box protein D3
- Transcription factor twist1
- Cadherin 1, type 1, E-cadherin
- Transcription factor SOX-10
- Paired box 3a
- Cadherin-2
- Crestin
- Transcription factor AP-2-alpha
Sequence:
MPRSFLVKKYFTNKKPNYSELESQTDRRYAVVPQCFPLDDPLVPKYPSMLVWSSSALPFPGVSSSVSCPPAPLDLSSPSSSSSSGEEDDCRTSDPPSPDPSDRFQCAHCGKSCSSPAALSRHQLAHCSPQDGISGATSSLTSSRAAFHCKHCPKEYNSLGALKMHIRSHTLPCVCSTCGKAFSRPWLLRGHIRTHTGERPFSCPHCNRAFADRSNLRAHLQTHSEVKKYQCGSCSRTFSRMSLLHKHTLSGCCPAL