wanglab/gogpt-training-data huggingface dataset:
Protein: Beta carbonic anhydrase 5, chloroplastic (AtbCA5) (AtbetaCA5) (EC 4.2.1.1) (Beta carbonate dehydratase 5) (Q94CE3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Reversible hydration of carbon dioxide.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:17407539}.
Interaction partners:
- Cyanate hydratase
- Lycopene beta/epsilon cyclase protein
- Enhancer of polycomb-like protein
- Alpha carbonic anhydrase 1, chloroplastic
- Tubulin-folding cofactor D
- Alpha carbonic anhydrase 2
- Dol-P-Glc:Glc
Sequence:
MAATPTHFSVSHDPFSSTSLLNLQTQAIFGPNHSLKTTQLRIPASFRRKATNLQVMASGKTPGLTQEANGVAIDRQNNTDVFDDMKQRFLAFKKLKYMDDFEHYKNLADAQAPKFLVIACADSRVCPSAVLGFQPGDAFTVRNIANLVPPYESGPTETKAALEFSVNTLNVENILVIGHSRCGGIQALMKMEDEGDSRSFIHNWVVVGKKAKESTKAVASNLHFDHQCQHCEKASINHSLERLLGYPWIEEKVRQGSLSLHGGYYNFVDCTFEKWTVDYAASRGKKKEGSGIAVKDRSVWS
Protein: Regulatory protein zeste (O61602)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVNKQYSATDLEAFMKIAANWQNSNHNLLEGVDIKTEMTQYMNSPSMNMYKKRERTQNWNHQEKKYLLDLCRKDMRIIENKRLDAGLTAVKNKAWKIIHQKFSNQFGTDRTCNRLKEQWRRMKACTRNEILDYNNRLARFGAEVADRKKPSPFTFEVWDFMQEAKKACKSEALDGIDYSKIPLALEEGFEYREDYKFNPEDHDMDDSRTPPQELCDVDIKEEENNETFNETFNHHHLNQSDILGSGERLSVSPNHSISRNGIHEAESPATISTSNVLDSSGAYMAGGGDMSGFQANFNMNNISATLEALNALRSGQFPSAAAAAAAAIHQHQAQAQVAMHHQHNNNNNNNNNNEDDEDSMKPQSKRQRTSSGSMLGSEDQAPVLAPSVPASSDSQALERSGSSNGLTMPGTAVSTNANSSSSNNNNFELRMFMEMQSKEHMMRMKILEVQLQAAKHSRDLVEINKTLALQKLQLELASKRLPS
Protein: Small ribosomal subunit protein uS13 (30S ribosomal protein S13) (P9WH61)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
Interaction partners:
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL22
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS9
- Translation initiation factor IF-1
- Large ribosomal subunit protein bL20
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS14B
- Uncharacterized protein Rv0500B
Sequence:
MARLVGVDLPRDKRMEVALTYIFGIGRTRSNEILAATGIDRDLRTRDLTEEQLIHLRDYIEANLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGMPVRGQRTKTNARTRKGPKRTIAGKKKAR
Protein: X-box-binding protein 1 (Q8MLW7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- non-specific serine/threonine protein kinase
- Atf6, isoform C
- Cryptocephal, isoform A
- Eukaryotic translation initiation factor 2-alpha kinase
- Endoplasmic reticulum chaperone BiP
- Mesencephalic astrocyte-derived neurotrophic factor homolog
- Calreticulin
- Eukaryotic translation initiation factor 2 subunit 1
- Apoptotic signal-regulating kinase 1, isoform C
- LD25575p
Sequence:
MAPTANTVLITVPRTAITSNNLPKLRPAPLTAALLKVSATPSASPTPSSSGYASSSNMDDDNMAASQPKAKKRRLDHLTWEEKVQRKKLKNRVAAQTSRDRKKARMEEMDYEIKELTDRTEILQNKCDSLQAINESLLAKNHKLDSELELLRQELAELKQQQQHNTRCISQSNASAGAEGCASTNLGSAAGYTTGGHTVVSASAGGAAEEQQEPGLTLESCGPLPTLQDMLGVDEEFDVKRLEELAESLLADITADLETGAGASSPAAAQDAGNAERLPGPMVGPAAERLESDGHRANGLNVEQEQETEHKVSLNVQMLKINGNPQHTTAAPASRTATITATAAASQLQATPDTVYGTYDAKTNSITIVMDGDAVPVNEAVEEIYCDGVSAGDDSTDVIMKCPPPATSPSQVYLNVMNAVDNSDDEESFDPIDRFLRPRVKAISPLAKSPALSLHSATSDHGYESILGSPTSVALTLPADEDDFPWESNFDELFPSLI
Protein: UDP-N-acetylglucosamine transporter YEA4 (P40004)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc) and is required for cell wall chitin synthesis.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:10788474}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- AMP deaminase
- Protein phosphatase PP2A regulatory subunit B
- Putative nucleotide-sugar transporter YMD8
- Dolichyl-phosphate-mannose--protein mannosyltransferase 4
- Thiamine-repressible mitochondrial transport protein THI74
- UDP-galactose transporter homolog 1
- GDP-mannose transporter 1
Sequence:
MWNSLKAFALVFGGCCSNVITFETLMSNETGSINNLITFCQFLFVTCQGLPEFLDVHQPFPYFKPLKTPLHVYVITVVLFYISSTTNNNVFKYNISIPIHIVFRCFGTVITMFTCWLLNGRKYTKIQILSTLFLTIGAIIASLFKDADFRYQDLKLQAWKIGSDQSVDLTFIFGICILVLSSFTSSLLSAYNERTYQKYGKHWKENIFYSHFLSLPLFLFSRKQLIHEYRVMRKSERILCSNFGGKILVPREETLLLFNVLTQYFCVKGVNILASKTNALTLSITLLVRKFISLLLSVRLFDNNLSYTGYIGVYLVFFGAFIYSLGSIHPRQNDKGAIKKSK
Protein: Hedgehog-interacting protein (D3ZGL3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Sonic hedgehog protein
- Hedgehog protein
- Hedgehog protein
- Patched
- GLI family zinc finger 1
- Protein smoothened
- Patched 2
- GLI family zinc finger 2
- Family with sequence similarity 13, member A
- GLI family zinc finger 3
Sequence:
MLKMLSFKLLLLAVALGFFEGDAKFGERSEGSGARRRRCLNGSPPKRLKRRDRRMMSQLELLSGGEILCGGFYPRVSCCLQSDSPGLGRLENKIFSATNNTECGRLLEEIKCAPCSPHSQSLFFSPERDVLDGDLALPLLCKDYCKEFFYTCRGHIPGLLQTTADEFCFYYARKDAGLCFPDFPRKQVRGPASNYLDQMEDYEKVEEISRKHKHNCFCVQEVMSGLRQPVGAVHSGDGSLRLFILEKEGYVKILTPEGEMLKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDVRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDADTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGRDYESEQSLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGASGSCQGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIIDPKRPLMPEECRVTVQPAQTLTSDISRLCRNGYYTPTGKCCCSPGWEGDFCRIAKCEPPCRHGGVCVRPNKCLCKKGYLGPQCERADRSMRRVTRAGILDQIIDVTSYLLDLTSYIV
Protein: Helicase POLQ-like (EC 3.6.4.12) (Mutagen-sensitive protein 301) (Protein spindle-C) (Spindle-C) (Q9VSE2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8TDG4}. Chromosome {ECO:0000250|UniProtKB:Q8TDG4}. Note=Localizes to sites of DNA damage. {ECO:0000250|UniProtKB:Q8TDG4}.
Interaction partners:
- DNA repair protein Rad51 homolog
- FI03211p
- DNA repair protein RAD51 homolog 3
- Exonuclease 1
- ATP-dependent DNA helicase Q4
- Serine/threonine-protein kinase ATR
- DNA repair and recombination protein RAD54-like
- DNA repair protein Rad1
Sequence:
MANKHNLCKKRSLDLSEESTSESHAKRQCTENLFWPEGEDDDSFFSNAHLEDLLDGRKEELFGTQATTSTNKMTQSGSDDGLGLFADTSFPSAQSVPPNSASKPDEASAPTDKHQIDLADEENADKLFKKINLNDLSIAEMEDIFHGADDFSDPMVQNTQLFLDAMTFKKPKTPEKLLAPLKDDSMSFISKSVIEGLVQGTQYVTCEELKNQSLLDPVNWETQAFADFEKNNQDIDKFPSKGEFYGLPDKVKKMILEHKGINSLYEWQDECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRERNVLFILPYVSIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFIASIEKGAVLMDSLIDVQRPHEIGLVVVDELHLIGEKGRGATLEAFLTKVMFLNANIQIVGMSATIGNLSEISSFLNADVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIFVPSRSVEYNYSEAVKRADPDHLAGLISECAPEHCCLVFCPSRKNCENVALLLSRIVPKHKFFEHRRSEKLDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAGRAGLGEAGESILIAQSKDNLLVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLVNSTLLSVQAKSLEVAVNEIVLRILREMFKNKVLQLAEPQAKSKINSSDIITSQDVSQANRPAGDRRLLIGQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQLILTNYLHLLYLVVCFNSNERGDELFPADASILFGVYTSLPLDSQAMFKQLGFTEAHAARLFKTQSVQGPLSLQLNRLYKVLILADILNLLPIPSVASKYNVERGTLQHLISQSTAAASAIVRLCEELEEFWCYKPLFERILHKMDRCGTFELEPLMELPAVKINRARQLYAAGFQTIGDIARVRPSHLVQSLEHMPLRVATEIVSAAKIILMKKLDHLEEETENLKDCLKTSDKN
Protein: Heme transporter hrg1-B (Heme-responsive gene 1 protein homolog B) (HRG-1B) (Solute carrier family 48 member 1-A) (Q6ZM28)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:Q6P1K1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6P1K1}. Lysosome membrane {ECO:0000250|UniProtKB:Q6P1K1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6P1K1}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9D8M3}; Multi-pass membrane protein {ECO:0000255}. Note=In macrophages, specifically localizes to the phagolysosomal membranes during erythrophagocytosis. {ECO:0000250|UniProtKB:Q9D8M3}.
Interaction partners:
Sequence:
MGPNRIYISVGYSTFGMLVGFSAFIVWNVVYKQPWTAAMGGLSGVLALWALVTHIMYIQDYWRTWLKGLKFFMFVSSVFSLLAVAAFATFITLSVIEKQSLSDPKSFYLSAVWSFMTLKWAFLLGLYSYRYRQEFADISILSDF
Protein: Co-chaperonin GroES (10 kDa chaperonin) (Chaperonin-10) (Cpn10) (P0A6G1)
Organism: Escherichia coli O157:H7
Function: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00580}.
Interaction partners:
- Chaperonin GroEL
- Chaperonin GroEL
- Chaperone protein DnaK
- Chaperone protein DnaK
- Protein GrpE
- Protein GrpE
- Chaperone protein DnaJ
- Chaperone protein DnaJ
- Chaperone protein ClpB
- Chaperone protein HtpG
Sequence:
MNIRPLHDRVIVKRKEVETKSAGGIVLTGSAAAKSTRGEVLAVGNGRILENGEVKPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA
Protein: Runt-related transcription factor (Q9DGB8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR009374}.
Interaction partners:
- Core-binding factor subunit beta
- Endothelial transcription factor GATA-2a
- GATA-binding protein 1a.
- T-cell acute lymphocytic leukemia protein 1 homolog
- Rhombotin-2
- Transcriptional activator Myb isoform 1
- Transcription factor GATA-3
- SI:bY184L24.2.1
- Protein CBFA2T1
- BHLH domain-containing protein.
Sequence:
MVFLWDAKYEPAPGRRFTPPSTTLSSGKMSEGLPLGAQESTGAALVGKLRMADRSMVEVLSDHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDIPDGTLVTVMAGNDENYSAELRNATAAIKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYQRAIKITVDGPREPRRHRQKPDEAVKPGALAFSEQLRRSAMRCSPHHGPAPNTRPTLNTPPFGSPAHSQIPDSRQMQTSPSWSYEQSYPYLGPISTPAVHPTTPISPNRTALHCPELTAFTDPRVGLERSFPSLPSLPDGRFSDPRVPYPTGAFTYTPTPVTSAIGIGMSAMSSPAGRYHTYLPPAYPAGSSQAQAGAFQASSSPYHLYYSSAAGSYQFSMMPSGGAAAGERSPPRILPCTNASTGSALLHPSLPNQSEGVVEAEGSHSSSPTSMSVEAVWRPY
Protein: Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain, skeletal muscle, adult 2) (Q9BE41)
Organism: Bos taurus (Bovine)
Function: Muscle contraction. Required for cytoskeleton organization (By similarity).
Subcellular location: Cytoplasm, myofibril {ECO:0000250|UniProtKB:G3UW82}. Note=Thick filaments of the myofibrils. {ECO:0000250}.
Interaction partners:
- Troponin C, skeletal muscle
- Myosin regulatory light chain 2, skeletal muscle isoform
- Myosin light chain 1/3, skeletal muscle isoform
- Myogenin
- Myoblast determination protein 1
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Troponin I, cardiac muscle
- Actin, alpha skeletal muscle
- Myosin light chain 6B
- Troponin T, slow skeletal muscle
Sequence:
MSSDQEMAIFGEAAPYLRKSEKERIEAQNKPFDAKTSVFVAEPKESFVKGTIQSREGGKVTVKTEGGATLTVKEDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEITSGKIQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNRKPELIEMLLITTNPYDYPFISQGEISVASIDDQEELIATDSAIDILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTVEQVTNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDMSFKNKLYDQHLGKSANFQKPKVVKGKPEAHFALIHYAGVVDYNITGWLEKNKDPLNDTVVGLYQKSALKTLAFLFSGTPTGDSEASGGTKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQYIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQLMTRTQARCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLFFRIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETISKAKGNLEKMCRTLEDQVNELKSKEEEQQRLINDLTTQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHGLQSARHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEAAQKEARSLGTELFKMKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRMHELEKIKKQVEQEKSEIQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQTMLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALKNYRNTQAILKDTQIHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDITQIQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQNRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE
Protein: Transmembrane 9 superfamily member 6 (Endomembrane protein 4) (Transmembrane nine protein 6) (AtTMN6) (Q9C720)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:P32802}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q940G0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Putative pentatricopeptide repeat-containing protein At3g16890, mitochondrial
- Pentatricopeptide repeat-containing protein At4g14850
- Pentatricopeptide repeat-containing protein At1g62260
- RNA helicase
Sequence:
MAIRIRISGTLLLSFLFFSTLHAFYLPGVAPRDFQKGDPLYVKVNKLSSTKTQLPYDFYYLNYCKPPKILNTGENLGEVLRGDRIENSVYTFEMLEDQPCRVGCRVRVDAESAKNFREKIDYEYRANMILDNLPVAVLRQRKDGIQSTTYEHGYRVGFKGSYEGSKEKKYFIHNHLSFRVMYHRDQESESSRIVGFEVTPNSVLHEYKEWDENNPQLTTCNKDTKNLIQSNTVPQEVEEGKEIVFTYDVAFKESVIKWASRWDTYLLMNDDQIHWFSIINSLMIVLFLSGMVAMIMMRTLYKDISNYNQLETQDEAQEETGWKLVHGDVFRTPMNSGLLCVYVGTGVQIFGMTLVTMIFALLGFLSPSNRGGLTTAMVLLWVFMGIFAGYSSSRLHKMFKGNEWKRITLKTAFMFPGILFAIFFVLNTLIWGERSSGAIPFSTMFALVCLWFGISVPLVFIGSYLGHKKPAIEDPVKTNKIPRQVPEQPWYMKPGFSILIGGILPFGAVFIELFFILTSIWLNQFYYIFGFLFIVFLILIVTCAEITIVLCYFQLCSEDYNWCWRAYLTSGSSSLYLFLYSVFYFFTKLEISKLVSGVLYFGYMIIISYSFFVLTGSIGFYACLWFVRKIYSSVKID
Protein: Paired box protein Pax-6 (Aniridia type II protein) (Oculorhombin) (P26367)
Organism: Homo sapiens (Human)
Function: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P63015}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:P63016}.; SUBCELLULAR LOCATION: [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}.
Interaction partners:
- DDB1- and CUL4-associated factor 7
- Transcription factor SOX-2
- Barrier-to-autointegration factor
- Homeobox protein SIX3
- T-box brain protein 1
- Microphthalmia-associated transcription factor
- Neurogenin-2
- Insulin
- Transcription factor Maf
- Transcription factor SOX-1
Sequence:
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ
Protein: Ribonuclease H1 (RNase H1) (EC 3.1.26.4) (Q86MG7)
Organism: Caenorhabditis elegans
Interaction partners:
- Ribonuclease H2 subunit A
- ribonuclease H
- Small, acid-soluble spore protein gamma-type
- DNA topoisomerase 1
- Protein hsr-9
Sequence:
MGKNDQYYAVARGKQVGIYRTWNECKTQIDGFQNARFKKFATEAEARKFVADNMSVPGSKPVTPAVSTSSATRKRTHEGTKFTEAKKMKTEEEVIDPEFANAPVVYTDGACSSNGTKNAKAGWGVYWGDDSEDNEFGPVYGAPTNNRGELIAVQKAIEKAIEKRLPKVVIKTDSNLLVQSMNIWIHGWKRKGWKTSTGSEVLNQDVLMKIDNLRQKLKVKFLHVRGHAGIDGNEKADELARKGAQMFIKRS
Protein: Phosphatidylinositol-3-phosphatase myotubularin-1 (AtMTM1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) (F4J3T8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphatase with phosphoinositide 3'-phosphatase activity that can use phosphatidylinositol-3-phosphate (PtdIns3P) and phosphatidylinositol-3,5-diphosphate (PtdIns3,5P(2)) as substrates and produces phosphatidylinositol-5-phosphate (PtdIns5P); participates in pathway(s) that transfer gene regulatory signals to the nucleus. Required for recovery after water deprivation, via the accumulation of PtdIns5P upon dehydration; high PtdIns5P levels mediate ATX1 cytoplasmic localization, thus down-regulating the expression of ATX1-dependent genes. Confers sensitivity to soil-water-deficit stress.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22324391}. Endosome membrane {ECO:0000269|PubMed:22324391}; Peripheral membrane protein {ECO:0000269|PubMed:22324391}. Note=Present in granular particles of varying abundance and size at the cell periphery and throughout the cytoplasm.
Interaction partners:
- Phosphatidylinositol 3-kinase VPS34
- Probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 4-kinase beta 1
- 1-phosphatidylinositol-3-phosphate 5-kinase FAB1A
- Phosphoinositide phosphatase SAC5
- Phosphoinositide phosphatase SAC4
- Phosphoinositide phosphatase SAC3
- Phosphoinositide phosphatase SAC2
Sequence:
MTPPRPPSGRVRSLRDYSSESEKMDGTGSWDTLEWTKLDSTSGSGSFSNLSCLLESERVIVEGYGVVLINTDEAGTLLVTNFRILFLSEGTRKVIPLGTIPLATIEKFNKMVLKVQSSPRQSDKIPPRRLLQVTGKDMRIIVYGFRPRTKQRRNVFDALLKCTKPERVWDLYTFACGPSKFGNANPKERLLNEYFRLLGKSSIRASMDMIEDGAFTLSNELWRISDLNSNYNLCQTYPFAFMIPKSISDAELLQACSFRARCRLPVITWCQPGSGAVIARSSQPLVGLMMNMRSNLDEKLVAAFCSQLPGAKGERRKLYIADARPRKNALANGAMGGGSESSSNYFQSEIVFFGIDNIHAMRESFSRVRDYLDMHGTTSSDGRSSFLRHGGWTWGGGNLSSMSASVSLLGDSGWLIHIQSVLAGAAWIAARVAMESASVLVHCSDGWDRTTQLVSLACLLLDPYYRTFAGFQALVEKDWLAFGHPFSDRVGMPNISGSGNFDFPRQSSSAGSFPSSPVRQSSGSAASQSSSSSHGHNNYSPIFMQWIDSVSQLMRMYPCAFEFSPTFLVDFMDCLLSCRFGNFLCNSEKEREQCGIADACGCLWAYLTDLRSFSATSHVHCNPFYDPLKYDGPLLPPAASLAPTLWPQFHLRWACPEEAKAADIGVQCRAMTVKYSEMQKEKEAAERRVDEISFAMESLSAELLRERHLSWVARESANRATKEYAALTRAVQSLGCKINFTTSDVEDDPRSSLENNPRRRNRHGNNSDVSVSISLMPEENTSGNPKGRVCEALCPLRTREGVCRWPEVGCAHVGSQFVGLKANFDAFDRLAIYDSYFQPK
Protein: Metal-ion transporter, putative (Q57YU8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEEASSEHQRLLPCSSGPHSNYNAAAVEVGTPAAPSPWGGLEDADQQSLNSTEVRRRHESKVLLAALMFCFVFMLVELMFGVVAHSLALLTDASHLLIDVGAYALSIMSLRAASRTSCGKYSYGWHRAEVIGTLVSVFSIWALVVWIVMEGLDRSWNVVKCSRIHAMLATTAQQYKRNNSTSYYGFGNISQRPTVDKDGALTEATHMEMCTSIDSPIMVVVGVLGMVVNVVCAAILYFGGSHGHSHFGGSHHHSHSGNGEEEDSLCEENTGHNHSHDHGHGHGHSGSEGEGHDHSHSHSGRGFAVHAALLHALGDCVQSLGVILAGIFIYVANRYSYGVPSYRYSIYNLADPLCSLLFAVITLNMTRPLLRDLLGILMESTPPGINYSELLSALRSIKGVEGVHDLHVWSIASDYAALSVHLEADDKDAALQEAQEVCKRFGITHTTIQVDTVENGAGLCHSLCASAQTIA
Protein: 5'-deoxynucleotidase YBR242W (EC 3.1.3.89) (P38331)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Interaction partners:
Sequence:
MTATITNKKSCSGSVEAGKTRLTTEWKPESQVPQYVKNELSKPHPNYILAFLNVVQQLKIQRRTGYLDLGIKECESISDHMYRLSIITMLIKDSRVNRDKCVRIALVHDIAESLVGDITPVDPIGKEEKHRREWETIKYLCNALIKPYNEIAAKEIMDDWLAYENVTSLEARYVKDIDKYEMLVQCFEYEREYKGTKNFDDFFGAVASIKTDEVKGWTSDLVVQRQKYFADLTQSITK
Protein: Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (Cytoplasmic tRNA adenylyltransferase 1) (Needs CLA4 to survive protein 6) (Thiolation of uridine in cytoplasmic tRNA protein 1) (P53088)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. May also be involved in protein urmylation and in invasive and pseudohyphal growth.
Subcellular location: Cytoplasm. Mitochondrion.
Interaction partners:
- Cytoplasmic tRNA 2-thiolation protein 2
- Adenylyltransferase and sulfurtransferase UBA4
- Ubiquitin-related modifier 1
- Thiosulfate sulfurtransferase TUM1
- Elongator complex protein 3
- Elongator complex protein 1
- Elongator complex protein 5
- Cysteine desulfurase, mitochondrial
- Elongator complex protein 6
- Minichromosome maintenance protein 5
Sequence:
MSFTAPSDPVNKPTKVKVSQLCELCHSRKALIRRPKNLSKLCKQCFCLVFETEIHNTIVANNLFQRGEKVAVGASGGKDSTVLAHMLKLLNDRYDYGIEIVLLSIDEGIIGYRDDSLATVKRNQQQYGLPLEIFSFKDLYDWTMDEIVSVAGIRNSCTYCGVFRRQSLDRGAAKLGISHVVTGHNADDMAETVLMNILRGDVARLEKSTAIITQSSGSPIKRSKPFKYSYQKEIVLYAHYMKLDYFSTECTYAPEAFRGTAREYMKNLEAVRPSCIIDIIQSGENLALKAKKSNAGKRVVKFVDGNRCARCGYLSSNNICKACMLLEGLEKSRAQVAIENDTSADGAALKLRALEKLSF