wanglab/gogpt-training-data huggingface dataset:
Protein: Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (Q38EJ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Adenylosuccinate synthetase
- adenine phosphoribosyltransferase
- adenine phosphoribosyltransferase
- Adenosine monophosphate deaminase, putative
- AMP deaminase, putative
- AMP deaminase
- Adenosine kinase
- Adenosine kinase
- Inosine-5'-monophosphate dehydrogenase
- Inosine-5'-monophosphate dehydrogenase
Sequence:
MEKGSPSDLNGVDYSVDNPLFALSPLDGRYKRQTKALRAFFSEYGFFRYRVLVEVEYFTALCKDVPTIVPLRSVTDEQLQKLRKITLDCFSVSSAEEIKRLERVTNHDIKAVEYFIKERMDTCGLSHVTEFVHFGLTSQDINNTAIPMMIRDAIVTLYLPALDGIIGSLTSKLVDWDVPMLARTHGQPASPTNLAKEFVVWIERLREQRRQLCEVPTTGKFGGATGNFNAHLVAYPSVNWRAFADMFLAKYLGLKRQQATTQIENYDHLAALCDACARLHVILIDMCRDVWQYISMGFFKQKVKEGEVGSSTMPHKVNPIDFENAEGNLALSNALLNFFASKLPISRLQRDLTDSTVLRNLGVPIGHACVAFASISQGLEKLMISRETISRELSSNWAVVAEGIQTVLRRECYPKPYETLKKLTQGNTDVTEEQVRNFINGLTDISDDVRAELLAITPFTYVGYVPRFSAK
Protein: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) (Q15173)
Organism: Homo sapiens (Human)
Function: As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8703017}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Shugoshin 1
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Protein phosphatase 1 regulatory subunit 1A
- Meiotic recombination protein REC8 homolog
- Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
- Apoptosis regulator Bcl-2
Sequence:
METKLPPASTPTSPSSPGLSPVPPPDKVDGFSRRSLRRARPRRSHSSSQFRYQSNQQELTPLPLLKDVPASELHELLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRTLPPSENPEFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILHRVYGKFLGLRAYIRKQCNHIFLRFIYEFEHFNGVAELLEILGSIINGFALPLKTEHKQFLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKEVMFLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIEDNCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQEQQKAQERQELWQGLEELRLRRLQGTQGAKEAPLQRLTPQVAASGGQS
Protein: Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (Q9USZ1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03061, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS5
- Putative ribosomal recycling factor
- Large ribosomal subunit protein eL15A
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL12m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein uL29
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein bL27m
Sequence:
MLKLSFRSLTSRLPRLSTLVVRGYASVANTGIEASNTSENNLNIQEQLNDNDKKRLKQIRNIGISAHIDSGKTTFTERVLYYTGRIKDIHEVRGKDNVGAKMDFMELEREKGITIQSAATHCTWERTVDQIEANEKQKTDFEKSYNINIIDTPGHIDFTIEVERALRVLDGAVLVLCAVSGVQSQTITVDRQMRRYNVPRISFVNKMDRMGADPWKVIQQINTKLKIPAAAVQIPIGQEDKLEGVVDLIQMRAIYNRGSKGEKIEISQQVPENLIELAKEKRSALIEKLADLDEEIADIYVMEEDPTPEQLMGAIRRTTLARKFTPVLMGSALSNVGVQSVLDAVCDYLPNPSEVENIALNAADSEKPVSLVPSSEKPLVALAFKLEEGRFGQLTYLRIYQGTLKRGNYIYNVNSTKKIKVSRLVRMHSNDMEEIEKVEAGGICALFGIECASGDTFTDGSVSYTMTSMFVPEPVISLSLKPKSKDTTSFSKALNRFQREDPTFRVQLDNESKETIISGMGELHLEVYVERMRREYKVDCETGKPRVAFRETLSKKVPFSYLHKKQSGGAGQYAKVEGYIEYMDGVEDESGNVVDCEFINKVTGGTVPTQYIPACEKAFYEALKKGFLIGHPIKNCRFVLEDGAYHPVDSSELAFRLATISAFRTAFLQANPMVLEPIMNVSITAPVEHQGGVIGNLDKRKATIVDSDTDEDEFTLQAEVPLNSMFSYSSDIRALTKGKGEFSMEFLKYLPAPKYVQKELVDAYNKQQQK
Protein: Cytochrome b mRNA maturase bI2 (P03873)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: This protein is responsible for splicing and maturation of cytochrome b mRNA. Specifically, it may be responsible for the splicing specificity of the second intron.
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cytochrome c oxidase subunit 3
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- Intron-encoded DNA endonuclease aI5 beta
- Cytochrome c oxidase subunit 2
- Putative COX1/OXI3 intron 1 protein
- Cytochrome b
- Intron-encoded RNA maturase bI4
- Cytochrome c oxidase subunit 1
- Cytochrome b mRNA maturase bI3
Sequence:
MAFRKSNVYLSLVNSYIIDSPQPSSINYWWNMGSLLGLCLVIQIVTGIFMAMHYSSNIELAFSSVEHIMRDVHNGYILRYLHANGASFFFMVMFMHMAKGLYYGSYRSPRVTLWNVGVIIFILTIATAFLGYCCVYGQMSHWGNMNIASNMFNMMKTIYMMMLMLLIYIFYTIMMRQMMKTKEYTMLIKSMDYINKNKYMINLNMTNKKDMNNNIGPLNMNILSIIYGSMLGDGHAEKRKGGKGTRIVFQQEYCNINYLYYLHSLLANLGYCNTNLPLIKTRLGKKGKIRQYLKFNTWTYDSFNMIYSEWYIKNMSGKGNIKVIPKSLDNYLTPLALAIWIMDDGCKLGKGLKFTTNCFSYKDVQYLTYLLHNKYNIKSTITKGNKENTQFVIYVWKESMPILTKIVSPYIIPSMKYKLGNYL
Protein: Focal adhesion kinase (EC 2.7.10.1) (Q9U5Y2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNTAGATSQPPPTKNEINSEEYLIHVHMPNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRTPSIQRYACRMLNMITKEVIWLARSTSMQKVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCFYYVNQVKEDFIQANVTAIEPEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVGPHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRSLITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKREQRKVASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYIIAQNPAVLAKLMMENQKRGINPAAYTTPASGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRSCSIPQGSLNDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPPNRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVWLWTAKNLFDVVDSIRQRYQHLFPPSATKETSCSSSFESTSGSIVTEPVNDLGGYIKTSTSGDLLQNTGIYDNDLHHSFNSQLQLQNPKASIDLSGGGSLQRGMSLGLDTTRSTNEPLRIVEETLGSPGEHMYCNTSALHGHA
Protein: Ubiquitin-conjugating enzyme E2 2 (E2 ubiquitin-conjugating enzyme 2) (Ubiquitin carrier protein UBC2) (Ubiquitin-protein ligase UBC2) (C8V8U3)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Ubiquitin-like domain-containing protein
- Ran specific GTPase activating protein An-RanGAP
- Ubiquitin-like activating enzyme
- SUMO activating enzyme
- Myosin-binding domain-containing protein
- Nucleoporin NSP1
- SUMO ligase SizA, putative
- KapN
- MIZ zinc finger domain protein
- [histone H3]-trimethyl-L-lysine
Sequence:
MSLCLNRLTEERKQWRKDHPFAFYAKPHRTAQGVLDMKRWECGIPGKKGTIWEGGLFKLDVTFPDEYPTKPPKCKFVPALFHPNVYPSGTVCLSILNEDEAWKPAITIKQILLGIQDLLDDPNPESPAQAEAYNMYKKDRAAYEKRVKQVVKENPAL
Protein: H(+)-transporting two-sector ATPase (EC 7.1.2.2) (Q580D6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- V-type proton ATPase subunit H
- V-type proton ATPase subunit C
- Vacuolar ATP synthase subunit D, putative
- V-type proton ATPase subunit a
- Vacuolar proton pump subunit B
- V-type proton ATPase subunit F
- 
- V-type ATPase, C subunit, putative
- V-type proton ATPase subunit
- Uncharacterized protein
Sequence:
MSSDRNPYKTEQRMGSVKAVSGPVVIAENMGGSAMYELVQVGSFRLVGEIIRLEGDTATIQVYEETGGLTVGDPVYCTGKPLSLELGPGIMSEIFDGIQRPLDTIYRMVENVFIPRGVQVKSLNDQKQWDFKPCLKVGDLISGGDIIGSVVENSLMYNHSIMVPPNIRGRVTSIVASGNYTLEDDIVELEYNGKVKSLKLMHRWPVRTPRPVASKESGNHPLLTGQRVLDALFPSVQGGTCAIPGAFGCGKTVISQALSKYSNSDAVIYVGCGERGNEMAEVLMDFPTLTTIIDGREESIMKRTCLVANTSNMPVAAREASIYTGITLAEYYRDMGKHIAMMADSTSRWAEALREISGRLAEMPADGGYPAYLSARLASFYERAGRVTCIGGPKREGSVTIVGAVSPPGGDFSDPVTSATLGIVQVFWGLEKRLAQRKHFPSVNWLISYSKYLKALEPFFNSLDPDYMRLRSVAAEILQREEELQEIVQLVGKDSLSESDKIILETAKVIREEFLQQNAFTPYDKYCPPYKTCWMLRNIVTFYEEGQRVVAESAGEHKITWNYIREKIPHVYTGLTEMKFRDPQEGEEANVKYYKKQHEEIMTAFASLVQ
Protein: Golgi matrix protein GM130 (Q5PXD5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
QSRFMELMQEKADLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKERHREKEEYISRLAQDKEEMKVKLLELQELVLRLVGDRNEWHGRFLAAAQNPADEPTSGAPAPQELGAANQQGDLCEVSLAGSVEPAQGEAREGSPRDNPTAQQIMQLLREMQNPRERPGLGSNPCIPFFYRADENDEVKITVI
Protein: Serine/threonine-protein kinase svkA (EC 2.7.11.1) (Severin kinase A) (O61122)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in regulation of actin cytoskeleton organization during cell motility; F-actin fragmenting and capping protein allowing dynamic rearrangements of the actin cytoskeleton. Also part of a regulatory pathway from the centrosome to the midzone, thus regulating the completion of cell division.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:18042625}. Nucleus {ECO:0000269|PubMed:18042625}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18042625}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18042625}. Cleavage furrow {ECO:0000269|PubMed:18042625}. Note=Shows overall localization in the cytosol and, to a lesser extent, in the nucleus. Enriched around the centrosome. In dividing cells, forms a cloud around the spindle and nuclei. Enriched in the cleavage furrow during late cytokinesis.
Interaction partners:
- Mo25-like family protein
- Striatin homolog
- Striatin-interacting protein homolog
- Serine/threonine-protein phosphatase 2A catalytic subunit A
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase roco11
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase qkgA
- Probable serine/threonine-protein kinase roco6
- T-complex protein 1 subunit theta
Sequence:
MASKKGDPEELYVRQEKIGKGSFGEVFKGINKKTNETIAIKTIDLEDAEDEIEDIQQEINVLSQCESPFVTKYFGSFLKGSKLWIIMEYLAGGSVLDLMKPGPFDEGYIAIILRELLKGLEYLHSEGKIHRDIKAANVLLSASGDVKLADFGVSGQLTDQMTKRNTFVGTPFWMAPEVIKQTGYDSKADIWSMGITALEMAKGEPPRADLHPMRALFLIPKDPPPTLEGNFSKGFKEFCALCLNKDPNQRPTAKDLLKHKFIKAAKKTSSLTDLIERRQKWLQLNGNNADDENDDLDRDAKSNEEDFGWEFPTIKQKSPVAVQEQQQTPQKPTVVSTPIKEQQQQQQPTPVTTPQQPVTTTTTTPTTETKVRSLSNSSQTTPVKTTVAATTAPATTPASNAPTSTTPNGAAVTQQQAPRASALTSVIYPVLSKLLKNTSDENVINALAQLKMAFDNAEKAKPGITHSLIAQIIETLKR
Protein: Beta-toxin KAaH2 (Peptide AaF1CA22) (Q4LCS9)
Organism: Androctonus australis (Sahara scorpion)
Function: Weakly inhibits the vertebrate potassium channel Kv1.1/KCNA1.
Subcellular location: Secreted {ECO:0000269|PubMed:15656785}.
Interaction partners:
Sequence:
MMKLMLFSIIVILFSLIGSIHGADVPGNYPLDSSDDTYLCAPLGENPSCIQICRKHGVKYGYCYAFQCWCEYLEDKNVKI
Protein: Coiled-coil domain-containing protein 74B (Q96LY2)
Organism: Homo sapiens (Human)
Interaction partners:
- Coiled-coil domain-containing protein 74A
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
- Proteasomal ubiquitin receptor ADRM1
- 26S proteasome regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 1
- 26S proteasome non-ATPase regulatory subunit 2
- 26S proteasome non-ATPase regulatory subunit 10
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome regulatory subunit 6B
Sequence:
MSGAGVAAGTRPPSSPTPGSRRRRQRPSVGVQSLRPQSPQLRQSDPQKRNLDLEKSLQFLQQQHSEMLAKLHEEIEHLKRENKDLRYKLIMNQTSQKKDGPSGNHLSRASAPLGARWVCINGVWVEPGGPSPARLKEGSSRTHRPGGKHGRLAGGSADTVRSPADSLSTSSFQSVKSISNSGKARPQPGSFNKQDSKADVPQKADLEEEPLLHNSKLDKVPGVQGQARKEKAEASNAGAACMGNSQHQGRQMGAAAHPPMILPLPLRKPTTLRQCEVLIRELWNTNLLQTQELQHLKSLLEGSQRPQAVPEEASFPRDQEATHFPKVSTKSLSKKCLLLSPPVAERAILPALKQTPKNNFAERQKRLQAMQKRRLHRSVL
Protein: Alpha-rhamnosidase (C8VMJ6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MISLPLLALATGAVASASCWRNTSCTGPSKPSFPGPWDSNNFAPGSRLIQPKSILSLPDGTYISDYTSDSHPSITTEDAGLVFDFGLEVGGIVTIDYSSSVPNTTLGLAFTEAKDYIGRTSDNSNGGTGADGALATLLTEGEGSYTMPDSQLRGGFRYLALFIPSSSSSNASLTIQSITLELAFQPTWSNLRAYQGYFHSSDPVLNKAWYAGAYTLQTNSVPRTTCRVSVSSATGWNNNAVCGPGETLLLDGAKRDRWVWIGDMGVAVPSASVSTGDTESTKNALLAIWDNQTPSGLLPKAGPPYLRADSDTYHLWTIIGTYNYFLFTEDYDFLAGIWQKYVKALDYSLAKITPLGIMNATQTADWGRWNYGTLASSANMLLYRSLTTAAFLAPYAGDNPENYTDLASTLRSAIVTHLYDSAVGAFRDSPNSTLYPQDANSMALAFSFFSQSPLNCSSSFNLAEAARVSSYLESNWTPIGPEVPELPNNISPFISSIELEGHFASGHADRAIELIRMLWGWYLAHPNGTQSTVPEGYLVDGSWGYRGDRGYRNDPRYVSHAHGWSSGPTSTLTEYAVGLKITKPKGSEWSLRPASFGIQGFEEAQAGFTTGLGKFKAAFRVQGKRATVTWDTPAGTKGWVQLPGEEGSWVEGGMGSLTVKL
Protein: Erythrocyte membrane protein 1, PfEMP1 (C6KT15)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MGPAPRTATTTYSSAKDLLEDIGESVQKEAKKQALGRSESVLHGLLSNATIKGVKNKATKPIQLEYEYHTNVTGGFDKNNPCANRLDVRFSDIYGGQCTDNKINGNDDETGGTCAPLRRLFLCDQHLSHMKEGNINNTDNLLLEVSLAAKYEGDSIINNYPDNRDKKEGICTALARSFADIGDIIRGKDLFLGYTKKDEKEKEKVQKNLKRIFNEIYKKMQDPAKSHYSGDSSDFYKLREDWWALNRKEVWKAITCKAKNDAEYFRKKDSDGKHCSVQNCKCVDGDPPTNLDYVPQHLRWFDEWSEEFCRKRKDQLKISLEKCRGKNKDKYCSLNGCNCKTTVRGKKKFDYQQECNDCLVACDPFVHWIDNEKLEFLKQKKKYKNEIKEREPTKKTSHGTINNMYAKEFYETLEKEHRTVDTFLKLLNEEKECKNHPEVGEGKKTFIDFNDNIETFSHTKICEPCPWCGVKPGGPPWKDNDIDSCGKKEISFSDKDTTDISILSTDRAKKNILQKLENFCRDTEHINHDIWKCHYENTDNDNCILQNENTGSEKQKIMPFDAFFFLWLTQMLDDSIEWRKKLKTCINNEKPTNCIRGCKKPCECFERWVEQKEEEWISIEKHFDKQRDISEEERYITLEYILNEFFMDKIEKAYGIEKSKELKEKLKSNKGHGIIRDTEHSQDAIKILLEHELEDAKKCTETHNDEKCKEQEESGGRSLNPDPESDDEEETDNVKENPCAVGKKLTKTVKQIARQMHQAAKKQLGSSSSRALKAHAHLGTYKHTNKRDDFKTICKITKDHSNATHNYPQGPCHGKNNDKSMFKTEEGWKPGNQINMNDEYAFMPPRRQHFCTSNLEYLETADRTLNGIGDDPNVLNHSFLGDVLLAAKFEADFIKEKYNEQSNYKDFSTICRAMKYSFADLGDIIKGTDLWDKNGGEQKTQGKLEKIFCKIKNKLPEDIQEKYINDDKNSPQYKKLREDWWEANRKEVWRAMTCATTSGKIPCSIVTPLDDYIPQRLRWMTEWSEWFCKEQSKLYGELVKDCASCKKKGKEKCTQGDNDCTPCDKKCKEYGKKIRTWKDQWTKMDGIYQMLYLQAQTTARNAGDTAFDNPNDQYVIDFFKKLQKANGDNNFGVNTSPYFTPAGYIHQEARVGECEVQKHFCNNNGNQDKYSFRNQPYDHEEACACKKNTKAPEKKKEETPPAGPNVCEIVDKLFEDTTTPHAACQQKYINGHEKFPNWKCVTPSGEKSGDKGAICVPPRRRRLYIHDLQSLDEKPSDTALRDWFVKSAAVETFFLWHRYKKQKEKKPQEGSLLSGSTLLSQFSIDLGDEEQPPEKQLAGGKIPDDFLRQMFYTLGDYRDICIGDENVIKTLKYSGDKDDIMEKIQEKIKAVFPTSGGTSHIPDVKPGGALSRGDWWEQHGKDIWHGMICALTYKETSGSGEKGEKTTITQDGTLKDALLDTDGKKPKRDYQYTSVTLKEDDSGEKAANVPAKVEPTTLADFTRRPAYFRWLEEWGDGFCRERKKRLAQIKKDCYEDGGTGEKQYSGYGEACDRTNTSNEGASADLEGPSCANSCSSYRKWIERKKYEFKKQEKAYGGQKQNCKKERKAAESNDNDKQFCGTPETTCNTAEAFLQNLGSCKKYNGEGKKIFENTEETFKPAIDCEPCSEFKVKLEKCNCGSDAKGNTCTTGKITAENFENKTDVNEVVMRVSDNAESGFKGDLKSSCENAHIFEGIKENKWKCRNVCGYIVCKLEEVNGEKDNGKKILLIRALVTHWVDNFLQDYNKIKKKLNTCMNSSDATPCIKGCVDKWIKLKKDEWEEIKKPYLEQYKNGYGENYNVKTILEKFQDQPEFKKAIGPCPTLDAFEKSKQCNATASSEKGKDGNKSYVIDCLLQELEKLQEKAKKCHDQHSDNPQEKCDDPHPDEPDEEDLLLEEEENTANSAPEICKDVIKAPPKQEEKGGCEPASPLEPEEVEEETASVPPGSEPEADKGPVKPAELPKPPKRNKRQPKKLYFPTPALQNAMLSNTIMWTIGIGFAAISYFFLKKKTKSTIDLLRVINIPKGDYGIPTMKSKNRYVPYKSGQYNGKKYIYMEGDESDDYTYIGDISSSDITSSESEYEDIDINNIYPYKSPKYKTLIDVVLEPSKRDTFNTQSDIPSDTSTNKFTDNEWNQLKQDFISNISQNSQMDLPKNNISGNIQMDTHPHVNILDDSMQEKPFITSIHDRDLHNGEEVTYNINLDDHKNMNFSTNHDNIPPKNDQNDLYTGIDLINDSISGNHNVNIYDELLKRKENELFGTNHTKHTTTNIVAKQTHNDPIVNQINLFHKWLDRHRNMCEQWDKNKKEELLDKLNEEWNKENKNNSNVTDTNGENNITRVLNSDVSIQIDMNSKPI
Protein: Outer protein D (Q9REZ6)
Organism: Bordetella bronchiseptica (Alcaligenes bronchisepticus)
Interaction partners:
Sequence:
MSVSPTSPGSFGAGPVFDSELQAPAPSAQRRGGAAPVPPPVDRRGVEPGDPTLGMLPAPDLLAGGAVSRTRAALDDLDAARLGEDIYTLMAVLQQASQQMREAARIARDAEATRQTQAIGDAASQMRQAANERMAGAIVAGAMQIAGGFVQLGAGLAAGLQAMGGAAAQAKGAAFSEQASTSRKVAAGLHDAPELQATVQARATQLEAQAASFGADAARSSAKSQRVSSVAQAGAATAGGIGGLTSAAQERRAAEHEARRAELDVEAKVHETASRRADEAMQQMLDIIRGIREKLAGMEQSRSETARSVARNI
Protein: Mediator of RNA polymerase II transcription subunit 18 (Cell separation protein sep11) (Mediator complex subunit 18) (RNA polymerase II mediator complex protein pmc6) (O14198)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 20
Sequence:
MQELYLLGVVPSRRFEAVVNSLSKTLDGPKTILEFWVVYRPKDVPPNLPRQPDSWLRLCSNIESHDETDTEWSKNTQWSMYLEGNSEPKREDKCGIRPVNRAKLTNGSVTEFVEKMGYEFSHEYIIQGLEYFFFDTTVRIYQTLIPSQQRSIKPPFHPMNEEQPWILHVYTHVADASNQVAMAKAEANLTKVKTLLSAFCDLKNVRL
Protein: Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) (O35899)
Organism: Cavia porcellus (Guinea pig)
Function: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P31645}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000250|UniProtKB:P31652}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:P31652}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q60857}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q60857}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q60857}. Note=Could be part of recycling endosomes. Density of transporter molecules on the plasma membrane is itself regulated by STX1A. Density of transporter molecules on the plasma membrane is also regulated by serotonin (By similarity). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity). {ECO:0000250|UniProtKB:P31645, ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857}.
Interaction partners:
- G-protein coupled receptors family 1 profile domain-containing protein
- D
- 5-hydroxytryptamine receptor 2A
- tryptophan 5-monooxygenase
- Amine oxidase
- Amino acid transporter
- 5-hydroxytryptamine receptor 1A
- Tryptophan 5-hydroxylase 2
- Amino acid transporter
- 5-hydroxytryptamine receptor 1D
Sequence:
METTALNSQKAPSVCKDREDCQENSILQKSGPTSAGGVESGQIFNGYSSVPSTGMGDDAEHSVPTATTTLVAEVHHGERETWGKKVDFLLSVIGYAVDLGNIWRFPYVCYQNGGGAFLLPYIIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYTICIIAFYIASYYNTIIAWALYYLISSFTDRLPWTSCRNSWNTANCTNYFSEDNITWTLHSTSPAEEFYIRHILQIHRSKGLQDVGGVSWQLTLCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWKGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSAVNCMTSFVSGFVIFTVLGYMAEMRSEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKHREWFVLAVVITCFFGSLTTLTFGGAYVVKLLEEYATGPAVLTVVFIEAIAVSWFYGVTQFCSDVKEMLGFSPGWFWRICWVAVSPVFLLFIICSFLMSPPQLRLFQYSYPHWSVILGYCIGTSSVICIPTYITYRLVTTPGTLKERIIKSITPETPTEIPCGDICLNAV
Protein: GH05723p (Q961V1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGLLSDPSISTQSKLVDGLARHVRKVCYALYVAGVAWFFCLALPEFNHGTYLSENALSPGLVYPEIRIDANRLAIQLLEELQRERKDHLSTTPHAWIAAKMNEFGLETHTHNYTLRYPFGGGKEYHGKNIYGILRAPRIASTEGIVFAAPYRAASSVHTDISASVPLLLAFADFARRKNYWAKDLIFLITEQEQLGMQAWLEAYHDGDRELDLSKAYLRPGNLPARAGSLQAALNIEVQDLEIDHVDVRIEGLNGKLPNLDMFNLVQRIMAREGIASGYKQAPRKKRRHSQSHFEQNFRQMLTMLASQSSGVPTGNHGLFHRYRIDALTIAANRRATHATLKGSPGSAAVPLLKAIEGIARSLNNLLERFHQSFFFYVIVSNDRYISIGDYMPALVALVACAFLKAYLTWSTLPATNAELEKAAGWLREHEQEAELEENLEPDKFELPYGSVLIYLTATLLIGFLCNVLPLQQYFLEIPMGAAPLTTSVLSFLSLIGFVLPFVVVLPPGGLELLHVAFLLIYGCALIVIGLLNFALGLFAAVLTVPLVIALETKEENSAAR
Protein: Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) (B0BNL2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Interferon regulatory factor 3
- Homeodomain interacting protein kinase 2
- Neutrophil cytosolic factor 1
- Neutrophil cytosol factor 4
- Cellular tumor antigen p53
- DNA-directed RNA polymerase subunit
- Cellular tumor antigen p53
- UDP-glucose 4-epimerase
- Gephyrin
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Sequence:
MADEEKLPSGWEKRMSRSSGRVYYFNHITNASQWERPSGGSTVGGGSKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRSKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Protein: Protein C1orf43 (Hepatitis C virus NS5A-transactivated protein 4) (HCV NS5A-transactivated protein 4) (Protein NICE-3) (S863-3) (Q9BWL3)
Organism: Homo sapiens (Human)
Function: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:31540829}. Mitochondrion {ECO:0000269|PubMed:31540829}.
Interaction partners:
- Endoplasmic reticulum membrane protein complex subunit 7
Sequence:
MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSRVQDIKYEPQLLADDDARLLQLETQGNQSCYNYLYRMKALDAIRTSEIPFHSEGRHPRSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGQNEYLRYQEALSELATAVKARIGSSQRHHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL
Protein: Kinesin-like protein at 67A, isoform A (EC 5.6.1.3) (Kinesin-like protein at 67A, isoform C) (RE52076p) (Q9VSW5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Kinesin-like protein Klp61F
- Kinesin-like protein
- Fascetto
- Kinesin heavy chain
- Bub1-related kinase
- CENP-meta, isoform C
- EG:BACR25B3.9 protein
- Protein claret segregational
- Aurora kinase B
- RT07324p
Sequence:
MPSEQHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKLREDNNGVVVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTVKLSMIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLADGLKHIPYRDSNLTRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNINYRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSKMEIAYQDLESLKREVNKSKAYQILIVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLEDGQKLTPEIEAVFERLLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEEPTCSLTASAKKRQRQAAQSDDDLHLSMEDFDSQDTESDSEELHRTFKRPRNLNETQVLGPCSSSSSSSTSSSSSARKALTATVTKPRTVQQRLVSDLISDQNVRGGNEKIKKALLKSNHFTAQGLQRTLAAASLAKENVKYNANYVRKSPRALMAKALAGTSTLARKPLGSASKEPPLVKFNRAASFRLKK
Protein: Uncharacterized protein, isoform B (A0A0B4KH92)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNCKLRRLDLLRNGQKSDCELHVSQPDKLKEGKRCPCIFRCHQVMLISASAEFERLIRDPEFQKNKRVISVDDASPTAYEALLLYIYTYEVCNAVTIDMCGDLMLLAERYEMLDFIDCYIDKLAHQEWPMEVVLQVFHLASEHHHPALMDLVAKPRRCSWTTRSSS