wanglab/gogpt-training-data huggingface dataset:
Protein: SAGA-associated factor 11 (Q5FC18)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03047}.
Interaction partners:
- SAGA complex subunit Sgf73
- SAGA complex subunit Sus1
- Probable ubiquitin carboxyl-terminal hydrolase 8
- SAGA complex subunit Ngg1
- SAGA complex subunit Hfi1
- SAGA complex/NuA4 acetyltransferase complex subunit Tra1
- SAGA complex subunit Sgf29
- SAGA complex/transcription factor TFIID complex subunit Taf12
- SAGA complex subunit Spt7
- SAGA complex/transcription factor TFIID complex subunit Taf9
Sequence:
MQPASLAGISCTIFENLLKDYTHELTQTVHKNAKLSLQKCPACNKHCRQYCTKPGYDIYGNSVQTPSNVPYYSCLMCKREIAASRYAAHLEKCKGRSLSNATSYSTLFEDDNADEED
Protein: Euchromatic histone lysine methyltransferase 1 (D4A005)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
Sequence:
MSAQAVLAKQETKQDCCMKTELLREDTLMAADEGSTEKQAGETPMAADGETNGSCEKSGDISHPNAPKHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQNHVTADDFMQTSVIGSNGYFLNKPALQGQPLRTPNTLNSSLPGHAAKTLPGGASKCRTPSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRVHRARKTMPKSILGLHAASKDHREVQDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMATTKSQTAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKVLDDSALHVNGESLEMDSEEEDSEELEDEEDRGAEQAAAFPTEDSRTSKESMSETDRAAKMDGDSEEEQESPDTGEDEDGGDESDLSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACKSSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLANGPDVLETDGLHEVPLCSCRMETPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEETSKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDEKSQSTVTQAPECFDPAGPAGFVRPTSGFSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQENGLPDTSSAAAADPL
Protein: Lipoprotein NlpI (P0AFB1)
Organism: Escherichia coli (strain K12)
Function: May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division. Negatively controls the production of extracellular DNA (eDNA).
Subcellular location: Cell membrane; Lipid-anchor.
Interaction partners:
- Tail-specific protease
- Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase
- RNA chaperone ProQ
- Murein DD-endopeptidase MepM
- Polyribonucleotide nucleotidyltransferase
- Lipopolysaccharide export system protein LptC
- Regulator of ribonuclease activity B
- UPF0352 protein YejL
- Murein DD-endopeptidase MepH
- Protein Syd
Sequence:
MKPFLRWCFVATALTLAGCSNTSWRKSEVLAVPLQPTLQQEVILARMEQILASRALTDDERAQLLYERGVLYDSLGLRALARNDFSQALAIRPDMPEVFNYLGIYLTQAGNFDAAYEAFDSVLELDPTYNYAHLNRGIALYYGGRDKLAQDDLLAFYQDDPNDPFRSLWLYLAEQKLDEKQAKEVLKQHFEKSDKEQWGWNIVEFYLGNISEQTLMERLKADATDNTSLAEHLSETNFYLGKYYLSLGDLDSATALFKLAVANNVHNFVEHRYALLELSLLGQDQDDLAESDQQ
Protein: Uncharacterized transporter mfc1 (Q9HDX4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Copper amine oxidase 1
- Copper transport protein ctr6
- Copper transport protein ctr4
- Metal-binding regulatory protein cuf1
- Copper transport protein ctr5
- Copper-binding regulatory protein cuf2
- Cytochrome c oxidase copper chaperone
- Cysteine synthase 1
- Small COPII coat GTPase sar1
Sequence:
MSVSDKDFKDIELLPVKSIESKDSIDQCDPLTWPIRIRIINTIIISFMTMLCMYGSSVFMPSIPELCEKFGEPETLVVLGATLYVIGVMLGPLIFSPLSELYGRRPLNIFGYTLFALMQIPTALSVNLAMFVVFRFFSGFFGSVGLGIGAGSLSDMFSKRDRGKYIGIYFLGICLGPAIAPIASGFIAGSSISWRWEFWILLMLSGVSLLAGVVFLKETYAPVLKRKQAKKLLEKQENQKSVEVKISEITESSQQIDPDKSFAEVVHILVTTIRRPLHLLCTQPIMILISLIVGTVYGILYLLFTAFAEVWISQYHFTSGLSGLTYISLSIGQVFAVFVLLPLNQKYWLSAVQKNNGVPEPEFRLPMAFLGCFAIMTGMFIFGWTVQYKVFWFVPLIGTTLVGAGFVMTFNPMNMFIVDNYGRYAASAMAAIAIPRNIFGACFPLFAEKLFERLGYGWGSSLLAFLLVAINFSIAALYMFGKTIREKRPFDHTKY
Protein: Ethanolamine ammonia-lyase reactivase EutA (Q9ZFV2)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Reactivates suicidally inhibited ethanolamine ammonia-lyase (EAL), cyanocobalamin-inactivated EAL and O(2)-inactivated EAL; requires Mg(2+), ATP and adenosylcobalamin. Reactivation probably occurs by the ATP-dependent exchange of cobalamin (By similarity). Protects EAL from inhibition by CN-B12, does not have adenosylation activity (Probable).
Subcellular location: Bacterial microcompartment {ECO:0000305}.
Interaction partners:
- Ethanolamine ammonia-lyase large subunit
- Ethanolamine ammonia-lyase small subunit
- Probable ethanolamine permease EutH
- Bacterial microcompartment shell protein EutL
- Acetate kinase EutQ
- Corrinoid adenosyltransferase EutT
- Probable acetate kinase EutP
- Ethanolamine utilization protein EutJ
- Bacterial microcompartment shell protein EutK
- Bacterial microcompartment shell protein EutS
Sequence:
MNTRQLLSVGIDIGTTTTQVIFSRLELVNRAAVSQVPRYEFIKRDISWQSPVFFTPVDKQGGLKEVELKALILAQYQAAGIAPESVDSGAIIITGESAKTRNARPAVMALSQSLGDFVVASAGPHLESVIAGHGAGAQSLSEQRMCRVLNIDIGGGTSNYALFDAGKVSGTACLNVGGRLLETDAQGRVVYAHQPGQMIIDEVFGSGTDARALAAAQLGQVARRMADLIVEVITGALSPLAQSLMQTGLLPADITPEVITLSGGVGECYRNQPADPFCFSDIGPLLATALHEHPRLREMNVQFPAQTVRATVIGAGAHTLSLSGSTIWLEDVQLPLRNLPVAIPQDDADLVNAWRQALLQLDLDPQTDAYVLALPATLPVRYAALLTVINALTAFVARYPNPHPLLVVAEQDFGKALGMLLRPQLPQLPLAVIDEVVVRAGDYIDIGTPLFGGSVVPVTVKSLAFPS
Protein: Eukaryotic translation initiation factor 4B (E7EX17)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRSKSDQDARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE
Protein: Cytochrome c peroxidase, mitochondrial (CCP) (EC 1.11.1.5) (P00431)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: Mitochondrion matrix. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}.
Interaction partners:
- Cytochrome c isoform 1
- Rhomboid protein 1, mitochondrial
- Cytochrome c isoform 2
- Peroxiredoxin TSA1
- Thioredoxin-2
- Superoxide dismutase, mitochondrial
- Peroxiredoxin PRX1, mitochondrial
- Dynamin-like GTPase MGM1, mitochondrial
- Glyceraldehyde-3-phosphate dehydrogenase 1
- Cytochrome c1, heme protein, mitochondrial
Sequence:
MTTAVRLLPSLGRTAHKRSLYLFSAAAAAAAAATFAYSQSQKRSSSSPGGGSNHGWNNWGKAAALASTTPLVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHTSGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWISSGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDADYVRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGPWGAANNVFTNEFYLNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQDKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL
Protein: At1g29190/F28N24_12 (F28N24.12 protein) (Phosphatidylinositol 4-phosphate 5-kinase MSS4-like protein) (Q9LP48)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g67620
- DUF4228 domain protein
- AGAA.5
- Uncharacterized protein At1g76660
- At1g64700
- Basic-leucine zipper transcription factor K
- Emb|CAB85509.1
- At1g71015
- Uncharacterized protein At5g17350
- Uncharacterized protein At5g66580
Sequence:
MKETIRCCIACILPCGALDVIRIVHSNGHVEEISGTITASEIMKAHPKHVLKKPSSPTSDHDERDVISATKIVIVPPEAELQRGKIYFLMPATKSDKCAGGGKIRREKSNANAVVKKRSQYRRQHRDGDEKCNGGESNDVKDKNYEKDLLISSDRYLTEILSEKVATQKDRRKGRVGVWRPHLESISEIITED
Protein: Transcription factor ATOH1 (Atonal bHLH transcription factor 1) (Class A basic helix-loop-helix protein 14) (bHLHa14) (Helix-loop-helix protein hATH-1) (hATH1) (Protein atonal homolog 1) (Q92858)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Achaete-scute homolog 1
- BarH-like 1 homeobox protein
- POU domain, class 4, transcription factor 1
- POU domain, class 4, transcription factor 3
- Mucin-6
- Unconventional myosin-VIIa
- Sonic hedgehog protein
- Mucin-5AC
- Zinc finger protein Gfi-1
- Transcription factor 4
Sequence:
MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS
Protein: Creatine kinase B-type (EC 2.7.3.2) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase M-type) (CPK-B) (P07335)
Organism: Rattus norvegicus (Rat)
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}. Cell membrane {ECO:0000250|UniProtKB:P12277}. Note=Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region. {ECO:0000250|UniProtKB:Q04447}.
Interaction partners:
- Creatine kinase M-type
- Ankyrin repeat and SOCS box-containing 9
- Guanidinoacetate N-methyltransferase
- Creatine kinase U-type, mitochondrial
- Alpha-enolase
- Mitochondrial disaggregase
Sequence:
MPFSNSHNTQKLRFPAEDEFPDLSSHNNHMAKVLTPELYAELRAKCTPSGFTLDDAIQTGVDNPGHPYIMTVGAVAGDEESYDVFKDLFDPIIEDRHGGYQPSDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLSGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQPIDDLMPAQK
Protein: Uncharacterized protein YhgE (P45804)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein YebB
- Uncharacterized protein YhhA
- Uncharacterized protein YfjT
- Uncharacterized protein YfeK
- Uncharacterized protein YobH
- Sulfite reductase flavoprotein alpha-component
- Probable autotransporter YfaL
- Oxamate carbamoyltransferase subunit AllH
- Stationary phase-inducible protein CsiE
Sequence:
MDNVELSPATRWGMIATGLLQGLVCYLLIAWLSGKNHSWIVYGVPATVAFSSVLLFSVISFKQKRLWGWLALVFIATLGMSGWLKWQTDGMNPWRAEKALWDFGCYLLLMAMLLLPWIQQSLRIRNDSSRYRYFYQSVWHNVLILLVIFLANGLTWLVLLLWSELFKLVGITFFNTLFFATDWFIYLTLGLVTALAVILARTQSRLIDSIQKLFTLIATGLLPLVSLLTLMFIITLPFTGLSAISRHISAAGLLLTLAFLQLILMAIVRDPQKASLPWTGPLRCLIKTALLVAPLYVFVAAWALWLRVAQYGWTVDRLQGVLAVLVLLVWSLGYFVSIVWRKGQNPVVLQGKVNLAVSLLVLVILVLLNSPVLDSMRISVNSHMARYQSGKNTSDQVTIYMLEQSGRYGRAALESLKSDAGFMKDPKRARDLLMALDGEQHLQQQVSEKVLADNVLIAPGSVKPDATFWSALIQDRYNVMTCIEKDACVLVEQDLNSDGQAERILFAFNDDRVIVYGFDSDRKEWDALDMSLLPNEITKEKLLTAAKDGKLGTKPKAWRDLVVDGERLNVNLNE
Protein: Monosaccharide-sensing protein 2 (Sugar transporter MSSP2) (Tonoplast monosaccharide transporter 2) (AtTMT2) (Q8LPQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sugar proton-coupled antiporter which contributes to vacuolar sugar import (e.g. monosaccharides including glucose, sucrose and fructose), particularly during stress responses (e.g. in response to cold).
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:17158605}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sucrose transport protein SUC4
- Sucrose transport protein SUC3
- Bidirectional sugar transporter SWEET10
- Bidirectional sugar transporter SWEET12
- Bidirectional sugar transporter SWEET17
- Bidirectional sugar transporter SWEET2
Sequence:
MSGAVLVAIAAAVGNLLQGWDNATIAGAVLYIKKEFNLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPSWRLMLGVLFIPSLVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRLRGREDVSGEMALLVEGLGIGGETTIEEYIIGPADEVTDDHDIAVDKDQIKLYGAEEGLSWVARPVKGGSTMSVLSRHGSTMSRRQGSLIDPLVTLFGSVHEKMPDTGSMRSALFPHFGSMFSVGGNQPRHEDWDEENLVGEGEDYPSDHGDDSEDDLHSPLISRQTTSMEKDMPHTAHGTLSTFRHGSQVQGAQGEGAGSMGIGGGWQVAWKWTEREDESGQKEEGFPGSRRGSIVSLPGGDGTGEADFVQASALVSQPALYSKDLLKEHTIGPAMVHPSETTKGSIWHDLHDPGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGILLSNMGISSSSASLLISALTTFVMLPAIAVAMRLMDLSGRRTLLLTTIPILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLEVITEFFSVGARQAEAAKNE
Protein: Fimbrial adapter PapF (P08408)
Organism: Escherichia coli
Function: Adapter that links the PapG adhesin to the distal end of the tip fibrillum. PapF is required for the correct presentation of the adhesin at the distal end of the tip fibrillum. Pili are polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, and enable bacteria to colonize the epithelium of specific host organs.
Subcellular location: Secreted. Fimbrium. Note=At the tip of the pili.
Interaction partners:
Sequence:
MIRLSLFISLLLTSVAVLADVQINIRGNVYIPPCTINNGQNIVVDFGNINPEHVDNSRGEVTKTISISCPYKSGSLWIKVTGNTMGGGQNNVLATNITHFGIALYQGKGMSTPLILGNGSGNGYGVTAGLDTARSTFTFTSVPFRNGSGILNGGDFQTTASMSMIYN
Protein: Transcription factor MYB120 (Myb-related protein 120) (AtMYB120) (Q94FL7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator. Binds to 5'-CAACTGTC-3' and/or 5'-TAACAAA-3' motif in target gene promoter to promote their expression (By similarity). Together with MYB97 and MYB101, functions as a male factor that controls pollen tube-synergid interaction in fertilization. Required for pollen tube growth arrest and sperm cell release in the female gametophyte, probably via the regulation of pollen tube-specific gene expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:23791732, ECO:0000269|PubMed:24278028}. Note=Detected in the vegetative nucleus of pollen tubes. {ECO:0000269|PubMed:23791732}.
Interaction partners:
- Gb|AAF16529.1
- F-box associated ubiquitination effector family protein
- Non-specific lipid transfer protein GPI-anchored 4
- GDSL esterase/lipase At2g31550
- GPI-anchored protein LORELEI
- Membrane lipoprotein
- Subtilisin-like protease SBT3.17
- Agamous-like MADS-box protein AGL30
Sequence:
MIMYGGGGAGKDGGSTNHLSDGGVILKKGPWTAAEDEILAAYVRENGEGNWNAVQKNTGLARCGKSCRLRWANHLRPNLKKGSFTGDEERLIIQLHAQLGNKWARMAAQLPGRTDNEIKNYWNTRLKRLLRQGLPLYPPDIIPNHQLHPHPHHQQQQQHNHHHHHHQQQQQHQQMYFQPQSSQRNTPSSSPLPSPTPANAKSSSSFTFHTTTANLLHPLSPHTPNTPSQLSSTPPPPPLSSPLCSPRNNQYPTLPLFALPRSQINNNNNGNFTFPRPPPLLQPPSSLFAKRYNNANTPLNCINRVSTAPFSPVSRDSYTSFLTLPYPSPTAQTATYHNTNNPYSSSPSFSLNPSSSSYPTSTSSPSFLHSHYTPSSTSFHTNPVYSMKQEQLPSNQIPQIDGFNNVNNFTDNERQNHNLNSSGAHRRSSSCSLLEDVFEEAEALASGGRGRPPKRRQLTASLPNHNNNTNNNDNFFSVSFGHYDSSDNLCSLQGKTKTTYNTSNLNYSSLQVKCKMFMIKTQI
Protein: E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) (Q3TTA7)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12842890}. Note=In adipocytes, translocates to the plasma membrane upon insulin stimulation.
Interaction partners:
- Tyrosine-protein kinase ZAP-70
- Epidermal growth factor receptor
- Tyrosine-protein kinase SYK
- SH3 domain-containing kinase-binding protein 1
- Growth factor receptor-bound protein 2
- Proto-oncogene tyrosine-protein kinase LCK
- E3 ubiquitin-protein ligase CBL
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- E3 ubiquitin-protein ligase CBL-C
- Tyrosine-protein kinase Fyn
Sequence:
MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFSIPMLDLDDDDDREESLMMNRLASVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPERPPPIPPDNRLSRHFHHGESVPSRDQPMPLEAWCPRDAFGTNQVMGCRILGDGSPKPGVTANSSLNGRHSRMGSEQVLMRKHRRHDLPSEGAKVFSNGHLATEEYDVPPRLSPPPPVTTLLPSIKCTGPLANCLSEKTRDTVEDDDDEYKIPSSHPVSLNSQPSHCHNVKAPVRSCDNGHCILNGTHGAPSEMKKSNIPDLGIYLKGGGSDSASDPVPLPPARPPPRDSPKHGSSVNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFFDPTSGQVPLPPARRAAGDSGKANRASQDYDQLPSSSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL
Protein: Aminopeptidase N (Q9VTL4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLLKILVLFCTLLSAKLAESFVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYTEMYSGQGIMVYGEDIVDSGQNGLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRSKDVKLILTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLLKAIRDFTLDDGPKNSSDSDSN
Protein: GRF-interacting factor 10 (ZmGRF10) (A5HEG9)
Organism: Zea mays (Maize)
Function: Involved in the regulation of cell proliferation in developing shoots and leaves. Does not possess transactivation activity.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU01002}.
Interaction partners:
- GIF2
- GRF-interacting factor 1
Sequence:
MTAEGEAKNPSAGGGGDNPQHQQAAPAPAPAQGEVAQEAAVQGTGQEQERDKADREVQGGAGEKDDGACRDLVLVEDPEVLAVEDPEEAAATAALQEEMKALVASIPDGAGAAFTAMQLQELEQQSRVYQYMAARVPVPTHLVFPVWKSVTGASSEGAQKYPTLMGLATLCLDFGKNPEPEPGRCRRTDGKKWRCWRNTIPNEKYCERHMHRGRKRPVQVFLEDDEPDSASGSKPAAPGKATEGAKKADDKSPSSKKLAVAAPAAVQST
Protein: ADD domain-containing protein 1, isoform A (A1Z8R2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Daxx-like protein
- Transcriptional regulator ATRX homolog
- Heterochromatin protein 1
- DNA repair protein Rad51 homolog
- Su
- Bonus, isoform C
- THO complex subunit 2
- Small ovary, isoform A
- LD35215p
- LD33778p
Sequence:
MSNSAPGSESGLAKVATPSPSPLAKLDADFTSSKFEMHPSLSDEERRFYLKMYPNVDLVNQRKVHCTVCKLHLGTAPAAESNIKMHPILRVTHCVKCHDFYNSGEFSKGEDGSELYCRWCGQGGEVYCCSTCPYVFCKSCIVKNLSKGVIVDIEQNENWNCFSCTSKILWPLRAQHWALVNYLQTQKRALQTLQLPEVEARRQMLKDNSNCCRLAKSKTSSLSDSMESLESNVSKRSQGSSAGSSKRGSMPKTIPPGPPSKRAKASNNEVVCTPDLLSMLEPDCQLSVTPKPTGRQTVTAANITTPRIVTVQQNYQPGQSSSNSGSNGSVSGSSSVPPTRSSLPPPLVLSGSGIRYRQNAPGGVSGVVRRTVVPNSVKTTGPVFHTINGFKVDLNSAAQQDSYRLPNGRLIQVKRQVPQTIQPASTVPTPPTPPALVVPQVGPGVVIRPRAPITTNRPSLHISTYGSNMGIYNPQTNQQQRAPQVRVGNANPAPPPLQGLPPNANGGQTLMITPAPQPAPKVPTLVRLTFPNTPMGQARAQLQEQIFSAMDICTHLTGKVVSLTHSNAYNQVRSYLELKELYIHMSYLMTYAIGRFKNLQEKCLVDMREKGFKNDANSLENGQLAADKQASDDEDNEIEIVEPKTDTITIDSDNEDDMPSTSTATQQEQPQETAIMKITSVTSEASKKELQENNQADIDVAAFSSTILASLLEVEVNEGASEPKPVSPGQKKQPRKKTTNKPNPALLQLERQRMEDMKKSDAKLKMKVMVKLKRAEDEFEVARKWVEDMKQGQELATKIKDSKAATPSNKTQKPSENLKISEKGSSAKKESTKQHGEGDKENTKNKEKIGDILKAAIKAKIGENEKLMAEDVQLPVDELLTEKDKELDKETLTSTEPETNKKSGTEKGSDKKQHLTKENNVKGESKDESKTDQKSDCKKGPDSECTEIEEETEMLSEKGYGGSEKEQGDTENMEDETSSERPTLIGEIEKNLLKEGKEESSEKFDKEVEPSKDVGKDSPTTQGKGQDSDKLKNARAGLKNSTQDASNTVEPPVAASNENDQSSVGELIERMDVTELDEKPKELLDCALDEVIPMEGIELSDDTEDLIKALGSPSVLPSQNTKDNETDLDANDFIGNLPLETTEPPEILLKEDECKVEKTTGISQVGAPSPAENGDTEMESTLEASDSAPDEFATAEIVG
Protein: Somatoliberin (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (P16043)
Organism: Mus musculus (Mouse)
Function: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
Subcellular location: Secreted.
Interaction partners:
- Growth hormone-releasing hormone receptor
- Somatotropin
- Somatostatin
- Growth hormone secretagogue receptor type 1
- Appetite-regulating hormone
- Agouti-related protein
- Amelogenin, X isoform
- BPI fold-containing family A member 2
- Guanine nucleotide-binding protein G
- Pro-glucagon
Sequence:
MLLWVLFVILILTSGSHCSLPPSPPFRMQRHVDAIFTTNYRKLLSQLYARKVIQDIMNKQGERIQEQRARLSRQEDSMWTEDKQMTLESILQGFPRMKPSADA