wanglab/gogpt-training-data huggingface dataset:
Protein: Protein CCA1 (MYB-related transcription factor CCA1) (Protein CIRCADIAN CLOCK ASSOCIATED 1) (P92973)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor involved in the circadian clock and in the phytochrome regulation. Binds to the promoter regions of APRR1/TOC1 and TCP21/CHE to repress their transcription. Binds to the promoter regions of CAB2A and CAB2B to promote their transcription. Represses both LHY and itself. Recognizes the promoter of JMJ14 to regulates its expression during the night in a circadian manner. Binds to the promoter of BHLH80/FBH1 and regulates its expression in response to warm temperature, thus contributing to temperature compensation of the circadian clock.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:19218364, ECO:0000269|PubMed:19339503, ECO:0000269|PubMed:9144958}. Note=Moves into the nucleus very soo after translation. This translocation is unaffected by light and dark.
Interaction partners:
- Protein EARLY FLOWERING 3
- Casein kinase II subunit beta-3
- Two-component response regulator-like APRR7
- Two-component response regulator-like APRR1
- Two-component response regulator-like APRR5
- Putative casein kinase II subunit beta-4
- Two-component response regulator-like APRR9
- Transcription factor LUX
- Protein GIGANTEA
- Protein LNK1
Sequence:
METNSSGEDLVIKTRKPYTITKQRERWTEEEHNRFIEALRLYGRAWQKIEEHVATKTAVQIRSHAQKFFSKVEKEAEAKGVAMGQALDIAIPPPRPKRKPNNPYPRKTGSGTILMSKTGVNDGKESLGSEKVSHPEMANEDRQQSKPEEKTLQEDNCSDCFTHQYLSAASSMNKSCIETSNASTFREFLPSREEGSQNNRVRKESNSDLNAKSLENGNEQGPQTYPMHIPVLVPLGSSITSSLSHPPSEPDSHPHTVAGDYQSFPNHIMSTLLQTPALYTAATFASSFWPPDSSGGSPVPGNSPPNLAAMAAATVAAASAWWAANGLLPLCAPLSSGGFTSHPPSTFGPSCDVEYTKASTLQHGSVQSREQEHSEASKARSSLDSEDVENKSKPVCHEQPSATPESDAKGSDGAGDRKQVDRSSCGSNTPSSSDDVEADASERQEDGTNGEVKETNEDTNKPQTSESNARRSRISSNITDPWKSVSDEGRIAFQALFSREVLPQSFTYREEHREEEQQQQEQRYPMALDLNFTAQLTPVDDQEEKRNTGFLGIGLDASKLMSRGRTGFKPYKRCSMEAKESRILNNNPIIHVEQKDPKRMRLETQAST
Protein: Transgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (P31232)
Organism: Rattus norvegicus (Rat)
Function: Actin cross-linking/gelling protein.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Actin, aortic smooth muscle
- Myosin-10
- Myosin regulatory light polypeptide 9
- Smoothelin
- Myocardin
- Actin, gamma-enteric smooth muscle
- Actin, alpha skeletal muscle
- WD repeat-containing protein 90
- Calponin-1
- Tropomyosin beta chain
Sequence:
MANKGPSYGMSREVQSKIEKKYDEELEERLVEWIVMQCGPDVGRPDRGRLGFQVWLKNGVILSKLVNSLYPEGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVTKTDMFQTVDLFEGKDMAAVQRTVMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTDSQLQEGKHVIGLQMGSNRGASQAGMTGYGRPRQIIS
Protein: Iron-regulated outer membrane protein (B5Z7N6)
Organism: Helicobacter pylori (strain G27)
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004571, ECO:0000256|PROSITE-ProRule:PRU01360}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004571, ECO:0000256|PROSITE-ProRule:PRU01360}.
Interaction partners:
Sequence:
MFLRSYPKLRYALCLPLLTETCYSEERTLNKVTTQAKRIFTYNNEFKVTSKELDQRQSNEVKDLFRTNPDVNVGGGSVMGQKIYVRGIEDRLLRVTVDGAAQNGNIYHHQGNTVIDPGMLKSVEVTKGAANASAGPGAIAGVIKMETKGAADFIPRGKNYAASGAVSFYTNFGDRETFRSAYKSAHFDIIAYYTHQNIFYYRSGATAMKNLFNPTQADKEPGTPSEQNNALIKMNGYLSDRDTLTFSWNMTRDNATRPLRSNAIGLAYPCEAPFSPDGAQGCPNVLDSFTRYMYHSINSANNFSLQYKREAGNSFGDPRLDFTLYTSIRNAQFDPLFDPNGVYAKFPTSQATAWEKENYPCVEGGYCTPSFSDVDKPSSQPRNLFLNNTGLNLKVAHVIDEATDSLFEYGFNYQNLSVFDARIPKSELYRPNQVYTDDKGQKQIACSLVDNNPNDPTLCQRGKANGNIYGGYVQANYSPHKIITFGAGVRWDAYTLYDKDWNHRYTQGFSPSAALVLSPIEPLSLKITYSQVTRGVMPGDGVYMRQNDLRYAKNIKPEVGSNAEFNIDYSSQYFSGRAAAFYQALDNFISQYAQSLIVTNLNQAIRIYGYEVGGTFRYKGVSLNVGISRTWPTTRGYLMADSYELAASTGNVFIIKLDYTIPKTGINLAWLSRFVTGLDYCGFDIYLPDYGTAEKPKTPTDLAKCGSQLGLVHMHKPGYGVSNFYINWSPKTKSRWKGLLLSAVFNNVFNKFYVDQTSPYVMSPDMPGTDAVKRAIAEPGFNARFEVAYKW
Protein: Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36 (NURP36); Neuromedin precursor-related peptide 33 (NURP33); Neuromedin-U-23 (NmU-23)] (Q9QXK8)
Organism: Mus musculus (Mouse)
Function: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract.
Subcellular location: Secreted.
Interaction partners:
- Neuromedin-U receptor 1
- Neuromedin-U receptor 2
- Neurotensin receptor type 1
- Galanin peptides
- Neurotensin/neuromedin N
- Neurotensin receptor type 2
- Appetite-regulating hormone
- Pro-neuropeptide Y
- Neuromedin-S
- Neuropeptide S
Sequence:
MSRAAGHRPGLSAGQLAAATASPLLSLLLLLACCADACKGVPISPQRLQPEQELQLWNEIHEACASFLSIDSRPQASVALRELCRIVMEISQKPQEQSEKDNTKRFLFHYSKTQKLGNSNVVSSVVHPLLQLVPQLHERRMKRFKAEYQSPSVGQSKGYFLFRPRNGKRSTSFI
Protein: Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1) (Q9BY67)
Organism: Homo sapiens (Human)
Function: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. May contribute to the less invasive phenotypes of lepidic growth tumor cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11279526, ECO:0000269|PubMed:22438059}; Single-pass type I membrane protein {ECO:0000269|PubMed:11279526}. Synapse {ECO:0000250|UniProtKB:Q8R5M8}. Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder. {ECO:0000250|UniProtKB:Q8R5M8}.
Interaction partners:
- Cytotoxic and regulatory T-cell molecule
- Band 4.1-like protein 3
- Hepatitis A virus cellular receptor 2
- Nectin-3
- Cell adhesion molecule 3
- MAGUK p55 subfamily member 3
- Protein 4.1
- Protein PALS2
- Syntenin-1
- Cell adhesion molecule 2
Sequence:
MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI
Protein: Retinoid-inducible serine carboxypeptidase (EC 3.4.16.-) (Serine carboxypeptidase 1) (Q920A6)
Organism: Rattus norvegicus (Rat)
Function: May be involved in vascular wall and kidney homeostasis.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MELSRRICLVRLWLLLLSFLLGFSAGSALNWREQEGKEVWDYVTVREDARMFWWLYYATNPCKNFSELPLVMWLQGGPGGSSTGFGNFEEIGPLDTRLKPRNTTWLQWASLLFVDNPVGTGFSYVNTTDAYAKDLDTVASDMMVLLKSFFDCHKEFQTVPFYIFSESYGGKMAAGISLELHKAIQQGTIKCNFSGVALGDSWISPVDSVLSWGPYLYSVSLLDNKGLAEVSDIAEQVLNAVNKGFYKEATQLWGKAEMIIEKNTDGVNFYNILTKSTPDTSMESSLEFFRSPLVRLCQRHVRHLQGDALSQLMNGPIKKKLKIIPDDVSWGAQSSSVFISMEEDFMKPVIDIVDTLLELGVNVTVYNGQLDLIVDTIGQESWVQKLKWPQLSRFNQLKWKALYTNPKSSETSAFVKSYENLAFYWILKAGHMVPADQGDMALKMMRLVTQQE
Protein: Cyclin-D4-1 (G1/S-specific cyclin-D4-1) (CycD4;1) (Q8LGA1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May activate cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion.
Interaction partners:
- Cyclin-dependent kinase A-1
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase B2-1
- Retinoblastoma-related protein 1
- Cyclin-dependent kinase inhibitor 6
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinases regulatory subunit 2
- Cyclin-dependent kinase inhibitor 7
- Cyclin-dependent kinase B2-2
- Cyclin-dependent kinase F-1
Sequence:
MAEENLELSLLCTESNVDDEGMIVDETPIEISIPQMGFSQSESEEIIMEMVEKEKQHLPSDDYIKRLRSGDLDLNVGRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKGWILQLLAVACLSLAAKIEETEVPMLIDLQVGDPQFVFEAKSVQRMELLVLNKLKWRLRAITPCSYIRYFLRKMSKCDQEPSNTLISRSLQVIASTTKGIDFLEFRPSEVAAAVALSVSGELQRVHFDNSSFSPLFSLLQKERVKKIGEMIESDGSDLCSQTPNGVLEVSACCFSFKTHDSSSSYTHLS
Protein: Probable purine permease 17 (AtPUP17) (Q1PFJ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEMSKASKQTTRHEESEHVQNPEPDQILSPRRSLELKQRKWWISVSLCLFLVLLGDSLVMLLLNFFYVQMKQDRREEYDQDLQYKGTWTQALIQNAAFPILIPLFFIFPKPKQHLETNNTSFLSLRLFFLYLSLGVLVAAHSKLFALGKLVSNYGIFSLISTTQLIFTAVLTAIINRFKFTRWIIISILLTIVIYVLGTPDFGGQPHDGEEFGYNIQAWLAFSATIAFSLSLCLIQLGFEKLQVKTKRYGNEKVFRMVLEMQICVAFVASVVCLVGLFASDEYKELKGDSKRFKKGETYYVLSLVGLALSWQVWAVGMIGLVHYVSGLFGDVVHMCASPFVALFVVLAFDFMDDVFSWPRIGALIGTVLALGSYFYTLHKRNKKKMAELNQSENNVEV
Protein: Coronatine-insensitive protein homolog 1b (OsCOI1b) (COI1 protein homolog) (OsCOI1H) (Q60EH4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in jasmonate (JA) signaling. Required for jasmonate signaling in plant defense responses. Can complement Arabidopsis coi1-1 mutant and restore jasmonate signaling. Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including TIFY/JAZ family (By similarity).
Interaction partners:
- Protein TIFY 6a
- Protein TIFY 8
- Protein TIFY 10b
- Protein TIFY 10a
- Protein TIFY 3
- Coronatine-insensitive protein homolog 2
- Coronatine-insensitive protein homolog 1a
- Protein TIFY 11e
- Protein TIFY 11d
- Protein TIFY 9
Sequence:
MGGEAPEARRLDRAMSFGGAGSIPEEALHLVLGYVDDPRDREAVSLVCRRWHRIDALTRKHVTVPFCYAASPAHLLARFPRLESLAVKGKPRAAMYGLIPEDWGAYARPWVAELAAPLECLKALHLRRMVVTDDDLAALVRARGHMLQELKLDKCSGFSTDALRLVARSCRSLRTLFLEECSIADNGTEWLHDLAVNNPVLETLNFHMTELTVVPADLELLAKKCKSLISLKISDCDFSDLIGFFRMAASLQEFAGGAFIEQGELTKYGNVKFPSRLCSLGLTYMGTNEMPIIFPFSALLKKLDLQYTFLTTEDHCQLIAKCPNLLVLAVRNVIGDRGLGVVADTCKKLQRLRVERGDDDPGLQEEQGGVSQVGLTTVAVGCRELEYIAAYVSDITNGALESIGTFCKNLCDFRLVLLDREERITDLPLDNGVRALLRGCTKLRRFALYLRPGGLSDTGLGYIGQYSGIIQYMLLGNVGETDDGLIRFALGCENLRKLELRSCCFSEQALARAIRSMPSLRYVWVQGYKASKTGHDLMLMARPFWNIEFTPPSSENANRMREDGEPCVDSQAQILAYYSLAGKRSDCPRSVVPLYPA
Protein: Small ribosomal subunit protein uS12z (40S ribosomal protein S23-1) (S12) (Q9SF35)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS12z
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein eS21z
- Small ribosomal subunit protein eS25z
- Large ribosomal subunit protein uL4y
- Small ribosomal subunit protein eS24z
- Large ribosomal subunit protein uL23y
Sequence:
MGKTRGMGAGRKLKQLRITQRWADKHYKKSNRGNEWKKPFACSSHAKGIVLEKIGIEAKQPNSAIRKCARVQLIKNGKKIAAFVPNDGCLNYIEENDEVLIAGFGRKGHAVGDIPGVRFKVVKVSGVSLLALFKEKKEKPRS
Protein: Nuclear fusion protein FUS1 (P11710)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for cell fusion. Negatively regulates Sho1p signaling to ensure efficient cell fusion.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Nuclear fusion protein FUS2
- Mitogen-activated protein kinase FUS3
- Protein SST2
- Protein STE12
- Protein STE5
- Karyogamy protein KAR4
- High osmolarity signaling protein SHO1
- Pheromone alpha factor receptor
- Serine/threonine-protein kinase STE7
- Protein PEA2
Sequence:
MVATIMQTTTTVLTTVAAMSTTLASNYISSQASSSTSVTTVTTIATSIRSTPSNLLFSNVAAQPKSSSASTIGLSIGLPIGIFCFGLLILLCYFYLKRNSVSISNPPMSATIPREEEYCRRTNWFSRLFWQSKCEDQNSYSNRDIEKYNDTQWTSGDNMSSKIQYKISKPIIPQHILTPKKTVKNPYAWSGKNISLDPKVNEMEEEKVVDAFLYTKPPNIVHIESSMPSYNDLPSQKTVSSKKTALKTSEKWSYESPLSRWFLRGSTYFKDYGLSKTSLKTPTGAPQLKQMKMLSRISKGYFNESDIMPDERSPILEYNNTPLDANDSVNNLGNTTPDSQITSYRNNNIDLITARPHSVIYGTTAQQTLETNFNDHHDCNKSTEKHELIIPTPSKPLKKRKKRRQSKMYQHLQHLSRSKPLPLTPNSKYNGEASVQLGKTYTVIQDYEPRLTDEIRISLGEKVKILATHTDGWCLVEKCNTQKGSIHVSVDDKRYLNEDRGIVPGDCLQEYD
Protein: protein-synthesizing GTPase (EC 3.6.5.3) (Q382L1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Translation initiation factor eIF2B subunit beta
- Eukaryotic translation initiation factor 3 subunit E
- Small ribosomal subunit protein uS5
- Eukaryotic translation initiation factor 3 subunit 8, putative
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit 7-like protein
- Translation initiation factor, putative
- Translation initiation factor, putative
- Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like C-terminal hexapeptide domain-containing protein
- Translation initiation factor eIF-2B alpha subunit, putative
Sequence:
MSENDIADFTIDETTLSSDPTRDCGLAAQNLSAMDLDKMSVETFEVMSRQATINIGTIGHVAHGKSTVVKALSGVKTQKYHREAVMNITIHLGYANAKVFRCDSCPVPAAYHAFPSSQPDKTGCPTCGAPLTLKRHFSFVDCPGHDVLMATMLNGAAIMDAALLLIAANEPFPQPQTLEHLKAVEIMKLRNLIILQNKIDLVGEVHAQDQYHKIRDYIDSTIGLSAPIIPISAQLKRNVDYLLEYLCRMPLPTRQLNCPARMTVVRSFDINKPGEVDIETLRGGVAGGTVIQGVLRVNQIVEIRPGQVHTQTGGTFSCTPLRTRALTLKAEDNSLQYAIPGGLIAVGTTLDPTLTRQDKMVGHMIGEEGSLPQVYAEIEVQYYLFSEMVGQSKQRDRNAKRVQKLNVQETLQINVGTLTAGATVVSITKSPDIAKLTLVTPVCCTMDEQIAISRLVEKNFRLIGWGTIRRGVPVKLN
Protein: GH11818p (Sulfotransferase 1 (EC 2.8.2.-)) (Q9W1L8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Negative elongation factor D
Sequence:
MPQSSFFAKSVPFEQIDKLAISGGYSSIFASSKPSVPVVGNWEQRFCRLADTFQPVLDRVYDFEVRDDDVWIVTLPKCGTTWMQELAWLVINECDFETAKSVDLTHRSPFLEFNGVVPNVPHDTIAAANALPSPRLIKSHLPAWMLPRQIWSKRPKIIYVYRNPKDAAISYFHHWRGMVGYQGTKSDFMHSFIDGYVNFTPCWPHILDFWQLRHEPNIFFTSYERMKGQLGQVISEVAQFLERSVSQEQMQQMQRHLSFESMRDNPACNHVKEFESMKAAAGREVEEFRFVRRGVVGSHKDELTADIIREFDLWSDSNLRDFKLNMDDFANYSKFAST
Protein: Hyperpolarization-activated ion channel variant DMIH-A1B2C2 (Q56JH7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MHVKHTQRRVSGPGAFGTFTNDQRASRDNLCPDNQQQQQQRHSHSHQHLVRQSLVSLSNGQPAASAAPDSVSLLRAGDDQQQHPQQPHLQQQQQQQQHLQQQQQRHRSSSSRLSTSGISKQNSSDSRSGLRILDSSHSPVSCGTQSVSSTGGQSALYDACHEYSRSLSAAAAEGAASLLKSHYSDQQLAQTEPDPEPDPERDRDRDRDRDRDRERERRHLTNLNLNLSSEYDYSGSDKQQLVNETYIFKCIANSPSFLRTNKIKEQSKKLRNLSLKTRTAKKKGQIISKSNAVSDNSLHPGDKYLNLYLVEKKHSLQPQVASTSSSINTTHPQASSAPASSSSTCTKAPQARQQQLLLNGSLKGKGQSQSQGQSRQTLPGHRASVRSESGSGSSHTIPATGKSPPVPHSLAAKISSSASGSKNCNLLSASSNSCHKLNAHAQGSGAGSGSGSGSGSGPPGHSHYAAASPKSSVSSNGHLNKYCLTDLTRRKAEFNRQLSAPTDYTHHSSSNGSQQEGSSEANEGHEPVGESTITVASAGVSYPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAEADDCKDDDMDLKENLLHGSESSIAEPVQTIREGLPRPRSGEFRALFEGNTP
Protein: AT3g60110/T2O9_90 (DNA-binding bromodomain-containing protein) (Q93ZQ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKEDEEEEAVISNGMNDDDDTNNINNSSTEFDNNRIGDGDDNSNLNQIKQVWGTWEELVLTCAVKRHAFSDWDSVAKEVQARSRSSLIVSAVNCRLKYQDLKRRFQDSVDVGDENTEAAANEEDEVGEISWLEQLRSLHMAELRREVQRCDDSILSLQLKVKKLEEEKDGDDGDNKPDLKNDETKPVRVNRETTESDRDDNRSMNESNSTASVDKIADHDRLDGDKMVKANENSRNPDPDPVNKAETPEEEERTVSKRSEMSNSGELDESGTSNCLGKRKGQKYRSGGGGGGVKSAGDKSQPLIDIIKLIRSHPRGSVFESRLRSQDTKDYKRLIRQHLDMKTIEKKMEKGSYVSSSLSFYRDLKLLFTNAIVFFPTSSSESIAAQELRTLVSNEMKKRTGKLGHCVIKSEAESSVSRQKSSVLSLVPCKKKSSALKKTSPSSSSRQKDEKKSQEVSEEKIVTTTATTSARSSRRTSKEIAVVAKDTKTGRAKNNIKKQTDTKTESSDDDDDEKEENSKTEKKTVADKKKSVADFLKRIKKNSPQKGKETTSKNQKKNDGNVKKENDHQKKSDGNVKKENSKVKPRELRSSTGKKKVEVENNNSKSSSKRKQTKETAEVATGKRGRESGKDDKQPRKRSRR
Protein: TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (F1QN44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Fc epsilon receptor IgFc epsilon receptor Ig
- Tyrosine-protein kinase.
- Fc receptor, IgE, high affinity I, gamma polypeptide-like.
- Tyrosine-protein kinase.
- CD247 molecule.
- Diverse immunoglobulin domain-containing protein 2.1.
- Novel immune-type receptor 9.
- Macrophage colony-stimulating factor 1 receptor
Sequence:
MRRILFIMFPVNGLFGFVEANQDCSSCYQMDIGVAVGIITCDIIVTLLIALSVYCFVSRQKKRGSLHAHGRCCSSGKAKLQQTSMRAKPIEVESPYQELYGVQSDIYSDLQQYRK
Protein: Armadillo repeat-containing X-linked protein 1 (ARM protein lost in epithelial cancers on chromosome X 1) (Protein ALEX1) (Q9P291)
Organism: Homo sapiens (Human)
Function: Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9CX83}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9CX83}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGRTREAGCVAAGVVIGAGACYCVYRLAWGRDENEKIWDEDEESTDTSEIGVETVKGAKTNAGAGSGAKLQGDSEVKPEVSLGLEDCPGVKEKAHSGSHSGGGLEAKAKALFNTLKEQASAKAGKGARVGTISGNRTLAPSLPCPGGRGGGCHPTRSGSRAGGRASGKSKGKARSKSTRAPATTWPVRRGKFNFPYKIDDILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQNAIRELGGVPIIAKLIKTKDPIIREKTYNALNNLSVNAENQGKIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDFFALLFLGNHFTKIQIMKLIINFTENPAMTRELVSCKVPSELISLFNKEWDREILLNILTLFENINDNIKNEGLASSRKEFSRSSLFFLFKESGVCVKKIKALANHNDLVVKVKVLKVLTKL
Protein: General transcriptional corepressor TUP1 (Flocculation suppressor protein) (Glucose repression regulatory protein TUP1) (Repressor AER2) (P16649)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- General transcriptional corepressor CYC8
- Regulatory protein MIG1
- CRE-binding bZIP protein SKO1
- Transcriptional regulator NRG1
- RFX-like DNA-binding protein RFX1
- Glucose transport transcription regulator RGT1
- DNA damage response protein kinase DUN1
- Silenced mating-type protein ALPHA2
- Repressor ROX1
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
Sequence:
MTASVSNTQNKLNELLDAIRQEFLQVSQEANTYRLQNQKDYDFKMNQQLAEMQQIRNTVYELELTHRKMKDAYEEEIKHLKLGLEQRDHQIASLTVQQQRQQQQQQQVQQHLQQQQQQLAAASASVPVAQQPPATTSATATPAANTTTGSPSAFPVQASRPNLVGSQLPTTTLPVVSSNAQQQLPQQQLQQQQLQQQQPPPQVSVAPLSNTAINGSPTSKETTTLPSVKAPESTLKETEPENNNTSKINDTGSATTATTTTATETEIKPKEEDATPASLHQDHYLVPYNQRANHSKPIPPFLLDLDSQSVPDALKKQTNDYYILYNPALPREIDVELHKSLDHTSVVCCVKFSNDGEYLATGCNKTTQVYRVSDGSLVARLSDDSAANNHRNSITENNTTTSTDNNTMTTTTTTTITTTAMTSAAELAKDVENLNTSSSPSSDLYIRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMILQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIEDGVTTVAVSPGDGKYIAAGSLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQNANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDRGVLFWDKKSGNPLLMLQGHRNSVISVAVANGSPLGPEYNVFATGSGDCKARIWKYKKIAPN
Protein: Uveal autoantigen with coiled-coil domains and ankyrin repeats (Q9BZF9)
Organism: Homo sapiens (Human)
Function: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:15358194}. Cytoplasm {ECO:0000269|PubMed:15358194}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15358194}. Note=Expressed diffusely in cytoplasm.
Interaction partners:
- Apoptotic protease-activating factor 1
- Galectin-3
- Cytochrome c
- Caspase-9
Sequence:
MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGLVC