wanglab/gogpt-training-data huggingface dataset:
Protein: Small nuclear RNA gene activation protein (SNAP) 50, putative (Q38E05)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- TATA box-binding protein-like 1
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- Plastid-encoded RNA polymerase subunit alpha
- non-specific serine/threonine protein kinase
- Probable 26S proteasome regulatory subunit rpn-6.2
- DNA-direcetd RNA polymerase II, subunit 9, putative
- Plastid-encoded RNA polymerase subunit alpha
- DNA-directed RNA polymerase II, putative
- DNA-directed RNA polymerase subunit beta
Sequence:
MPPKQLVDPFSLQVGNKKETTLANVAAHTAVTLTDIRRRNPQLDVYKISDKLPAGTIVHLPQTLSERGNPYGCFFTIGEAEDAMRKLEARLDRLLEEEGPNLPELPTRRVLSKMERIVTQVKEEGERQLARVREEYSECERRPALLQFLVDLEPVKRLREQLDEEYDGRKLRLKVMDEGNSELFRQAEPRYPNKGIAASLRHNVIDTSEDFCLTEHSHRWEFTFFTPGSTTEPQETWAVLSCQSLGTLLDTFVCRNCIPVNISKNAFFFIGGTFYVDNRHAGEGGEDYEDLTAPIRHFDPCGEGASTEGETRQKNIAFGNCPVKYVSQTTFGDLNLRLGEYGVMRHLGWCNHYFYLSSVTSLRGFDRDDHTRAAYPQRVMKTPTRVVRCRLCRSHPATVVCYNDEISPESPCPYCVPCFELLHATDEGEVEEGKFFAIRLPQGKYYTA
Protein: RNA-binding protein (Q57ZB1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDEKPRLIEHTSACRGTADVLILSGFPWYVTEGQVRKYLTEIHPSNIAPLTVRLYTNPANGSSRGICFVEYCPKQSNTGGASQGIKNEFPERKQKGEAEDIAALMKLRIEATAYERHYIRVLLYRLTNRNWDRGGRLPDLPTDPPPLATSRGGVLEGYGDEGFTVRCSALLGLANTVTPNGIASMQTLRKRFREEAAKAAMPNKSDEGYPGSSAARQ
Protein: F-box/FBD/LRR-repeat protein At2g04230 (Q6NKX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEQKFKTDSMNEDRISDLPDALLLQILSSLPTENAIATSVLSKRWRSLWTMLPKLKFDSNFNPVFDDDNIDPTMFSENVYKTLSLHKAPVLESLHLSFEGRTDCLHVGIWIATAFARGVRKLVLDSFYQEDQTVTLPSVLFSYNDSLEILKLKCAIDLDFPSRVCLKSLRKLYLDQVHFKDEESVCNLLCGCPSLQDLVVHRYSNADVATFTIASPSLQRLTIEDLRQEGGYGNGSYVINAPGLKYLNINGVIDIESCLIDKALELEEAKISNVSGITNENILESLTSAKRLILHLSPLEVKVPTGKIFDQLGCLELLTHEREWWNLLSIMLDSSPKLQILKLTDVYLHDNKTNPDERKWNPPKCAPECLLFHLETFLWIGYEWQRGDEKEVATYILENARRLKKATFSTKRIGREKLEDFEKRREMLNELAIVLWDSNSCHLVFEST
Protein: Uncharacterized protein C1orf94 (Q6P1W5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRGGGGCVLALGGQRGFQKERRRMASGNGLPSSSALVAKGPCALGPFPRYIWIHQDTPQDSLDKTCHEIWKRVQGLPEASQPWTSMEQLSVPVVGTLRGNELSFQEEALELSSGKDEISLLVEQEFLSLTKEHSILVEESSGELEVPGSSPEGTRELAPCILAPPLVAGSNERPRASIIVGDKLLKQKVAMPVISSRQDCDSATSTVTDILCAAEVKSSKGTEDRGRILGDSNLQVSKLLSQFPLKSTETSKVPDNKNVLDKTRVTKDFLQDNLFSGPGPKEPTGLSPFLLLPPRPPPARPDKLPELPAQKRQLPVFAKICSKPKADPAVERHHLMEWSPGTKEPKKGQGSLFLSQWPQSQKDACGEEGCCDAVGTASLTLPPKKPTCPAEKNLLYEFLGATKNPSGQPRLRNKVEVDGPELKFNAPVTVADKNNPKYTGNVFTPHFPTAMTSATLNQPLWLNLNYPPPPVFTNHSTFLQYQGLYPQQAARMPYQQALHPQLGCYSQQVMPYNPQQMGQQIFRSSYTPLLSYIPFVQPNYPYPQRTPPKMSANPRDPPLMAGDGPQYLFPQGYGFGSTSGGPLMHSPYFSSSGNGINF
Protein: Cyclic nucleotide-gated ion channel 11 (Cyclic nucleotide- and calmodulin-regulated ion channel 11) (Q9SKD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative cyclic nucleotide-gated ion channel.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Two pore calcium channel protein 1
- Probable LRR receptor-like serine/threonine-protein kinase At1g63430
Sequence:
MNLQRRKFVRLDSTGVDGKLKSVRGRLKKVYGKMKTLENWRKTVLLACVVALAIDPLFLFIPLIDSQRFCFTFDKTLVAVVCVIRTFIDTFYVIHIIYYLITETIAPRSQASLRGEIVVHSKATLKTRLLFHFIVDIISVLPIPQVVVLTLIPLSASLVSERILKWIILSQYVPRIIRMYPLYKEVTRAFGTVAESKRVGAALNFFLYMLHSYVCGAFWYLSSIERKSTCWRAACARTSDCNLTVTDLLCKRAGSDNIRFLNTSCPLIDPAQITNSTDFDFGMYIDALKSGVLEVKPKDFPRKFVYCFWWGLRNISALGQNLETSNSAGEIFFAIIICVSGLLLFAVLIGNVQKYLQSSTTRVDEMEEKKRDTEKWMSYREIPEYLKERIRRFEDYKWRRTKGTEEEALLRSLPKDLRLETKRYLFLKLLKKVPLLQAMDDQLLDALCARLKTVHYTEKSYIVREGEPVEDMLFIMRGNLISTTTYGGRTGFFNSVDLIAGDSCGDLLTWALYSLSSQFPISSRTVQALTEVEGFVISADDLKFVATQYRRLHSKQLQHMFRFYSLQWQTWAACFIQAAWKRHCRRKLSKALREEEGKLHNTLQNDDSGGNKLNLGAAIYA
Protein: Centrosomal protein of 152 kDa (Cep152) (Q498G2)
Organism: Xenopus laevis (African clawed frog)
Function: Necessary for centrosome duplication; the function seems also to involve cep63, cdk5rap2 and wdr62 through a stepwise assembled complex at the centrosome that recruits cdk2 required for centriole duplication. Acts as a molecular scaffold facilitating the interaction of plk4 and cenpj, 2 molecules involved in centriole formation (By similarity). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of cep152 can drive amplification of centrioles (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24075808}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:O94986}. Note=Colocalizes with cdk5rap2, wdr62 and cep63 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles (By similarity). Localizes to the deuterosome (PubMed:24075808). Localizes to pericentriolar material (PCM) (By similarity). {ECO:0000250|UniProtKB:O94986, ECO:0000269|PubMed:24075808}.
Interaction partners:
Sequence:
MSIDFDSGALQTQQEDEEYDKEDYAREQELQQLLTDLPHDMLDDSLSSSPEPSYSDCSGHEISEKIPQWEHGANWGNDDLPNHQKPYKNGFTENQYCMGFVGKQDEHLRNQAGRDKMSNGWDVLHANEDDPMFNGKYRYSKDHAYNSESNGQAFHGGDHYDAPGHCSSSELYHLPDDFQPYTNCQQVEHFPDSKKEHFQGFAVPEETSKISTEPFQVKYNPYQIKVARMDEMNQDPERRDGNFDDLQREFLDTGENSTGNMQFVQLQVLYKARGRQLEEQNNKLEESERQIRYLNHQLAIVKDQKDGLTISLQESQSLLQNSREMEIQLKGQLTALEKTVESLTTNEEQLRKELNISKVAMESFQQQLLDLRRSESIQRAREQHETVVSMLKKKHEEQVLALQQKLDDVNAMLNEEKELCSRLETRLKLSERKEAESKLEKTDIINRLSKSLEESQKQCANLLQSGSIQEATQLRLQLQQVQSSKIINDGMNKALQEEVRELQEQITMYESAARLGAFVNSGEEQQLSDSYVELGIKNFNWQKSRLGRIVANNGVKNDLSSEEIILELKTELERCLNSNKTKRKQIVQLQAELKGHLLKNEELKKSMEIAERTARDSQIQAENLANKVNNSPFYSSSSDRFREEIQKLQSEKQILQQENEKHLLFIKEFTVNEEKLKASNQELCNEMRGMIQDFDQDKKEAIERCERTYEQHNEDIKAHLLNELYEKFESEKELLSQGYEEKITLLQAQMNEIHREMAAVQECYIAVCKEKDALEENMREHFKKELQKSEEEVTAKAIQDVEMEWAQKLNQALQDAKTKSLQSFETQTIQTDESSLAKSDLNSDCIDELKVKLQNAIQEKEKAVHQAQLELEERHHEETSKQVEVALTRAYGRWLQELTSLPEYKARLKLEQEKWEKTNERNVERQVSDALYAAEIKWKMRSDKVDFTVRQKEFEEKIASMKRELELKAEESQALLKAEIATSRAQWNKEKHDEIQRLREDNEKDYRVFLDEHRNKLTDTLSTAKVEFEKQKNELIAQKDREMAERLDESLKQWALDESRRMRALENEILSEVEQCMYEIHDQLLDKSIVKDRLPSMKSNLDVTFLEKLKACLQKSVKGILYKVLANARQDWKKKYDTESNQETGIRGGELEGSDDRKTAKMWYLDKDLGKTEKQPCCEHWVQQLEKSKKECYEIRSKLEKACRHLQQLVKEQKLKAEKYRKNHILTEELKKQNSELQKKLELTVAPSPACLEPVEGGSNGCMMCNGNALEEIRAQYIKAVDKIKNDMLRYIHESKGRAAELLKSEVLRERQETARKMRKYYLTCLQQLLKDDGNNEGAEKKIINAASKLATMAKVLETPVSQKYQSKSLNSDLPQNENFLSETTQDQRSLQKPAHSHQNNNPLNQNIDQQTIEELIKRHVREKSDGNKVTDAEGASAINENSSFPTLRKSLVDNGNSQFVPSAPFQKLKTFSCIDSSTEGVLVTHQNKQSALQSGTLYPNSEHPKKKPGLQRFDLQETPVRDENGSNDWSCISSKSLFQPHSAKGSLTQLKMGPQNADVEEHSSAVASCSLAEENHNTFSSGARNQHFFAQVAKRKDENSGRKYSNKIQEPSATGIHPESKLFSDVGQGNKLPSRKLLLDFTLSPQQDSGFDSPFPNLNNFN
Protein: Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase) (P42285)
Organism: Homo sapiens (Human)
Function: Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand. Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex. Plays a role in DNA damage response.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:30842217}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:16782053}. Nucleus speckle {ECO:0000269|PubMed:30842217}.
Interaction partners:
- Nuclear nucleic acid-binding protein C1D
- Terminal nucleotidyltransferase 4A
- Exosome complex component 10
- Exosome complex component RRP45
- Zinc finger CCHC domain-containing protein 8
- Exosome complex component RRP4
- Zinc finger CCHC domain-containing protein 7
- Exosome complex component RRP46
- Ribosome biogenesis protein NOP53
- RNA-binding protein 7
Sequence:
MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLYL
Protein: DNA-directed RNA polymerase (EC 2.7.7.6) (Q95WT2)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MRRLSLAPIKWPAIAQRWGTRGTDVPNRAKGAIKSPKSRKSRLPYVEVGERTDRMKEFVSSGTDDNSGDSDNNHNSVKSINNTDCRNKGTDGGGEIDMDTVAGTDAFTPTVDMEEGYGAPVMATTGSTSSESVLSVIDVLCDDLFSCKTDVLKSFARTRSVSGSTKSELVMNLIDLANREAHGESQDLSITKRVLGDVFNEEVRVSGVRSQWTNKSLEASHIEMACDNHLKFEAMSYTQKTLMVRRNASESSRVLRKLIRPFQQDYNRVAEAAVGGVFRNFKAEADQLVNSMMASEIVTPFSSFLVSYVRFATSGNLLTRTNVIERLEQLELVQIAMDEDSDAVLQRLMALLDDVVAEVERRALCFGGKRTSWGTETPEVLRCSIQAFSDSTAQQHEDLGERVPAWVHDLVRMFNNWEAIVRTDIPVLEDVPRYVFDCILSGVVCYHLLHKIYGDIISPTDVPPTVRGAVKRAMEAHFKDEEKAGHALAKLFAYVQAPGDSGVVKAEFFPAVLSQMQGAFHDVGQSTLHNVRTAIVLREICATVSRCTRTCGLFHMLVKLTEDLRFQFRFSTIFKKLNGRDRTTIRTKYSINMVKTLEYFEQEYAVTPTSTKAVGFIVILLLHMSMCSGAASGHGTKAVLERYISVTNKEEFSIISISDLEATHVRDLRVAFPPQLSYNSWLHQSDTKDKSVYNVLPSVAVKGSTNQAMIISQAPMMKALDAISRVPWRISKYMLHVQEAIVREGYGFGKIRPAFYPLHYCAKSRGDISYESTGMDDDDDKTEVYNLQQRREYELQQDEDWKNLSELRSNRIHYLQALRQARSLVQFSHIYFPNSMDFRGRMYPLPGRLNHTGSDPFRALLEYAEPKPLGKEGLYWLKVHLANKMGMSKLSFDERVHYVNEHIDDVVCSAEQPLYGDKWWQEAAEPMQCLMACKELADALKCSQGPENFLSRIPVAVDGSYNGLQHYSAIGRDAFGATLVNLVPSERPADAYTGILKEMMSSIKADAERDHQWLQRCLGTGKGQDRDHIKRKTIKRPIMTQVYGVTGYGMSEQILDELVKQNKNHGLWTSTDMREMADYLREKVLESLGITFRETQNCRRWITDVSNIIWEVQPAELRTALCWTTPLGLVVRQPYKMRKEMMIFTVHGCARVPANAFSAASRKQLTAIAPNLIHSLDASHLAMTAIEMQNLGLSMMAVHDSYWTYACDLPTLSRVLREQFVTLYGKYDPLWELKEQWEEAYFMDLRRHGKVLPDPPKRGDLDLNVVLNSPYFFS
Protein: TATA box-binding protein-like 2 (TBP-like 2) (xTBPL2) (TATA box-binding protein-related factor 3) (TBP-related factor 3) (Q28DH2)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: TATA box-binding transcription factor. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis. Required for gastrulation. Regulates a large subset of genes that are ventrally expressed (By similarity). Binds to a subset of promoters.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q5UE94}.
Interaction partners:
- Transcription initiation factor TFIID subunit.
- TATA box-binding protein-like 1
- Arginyl-tRNA synthetase 2
- Neuronal PAS domain protein 3.
- TATA-box binding protein associated factor 6.
- B-TFIID TATA-box binding protein associated factor 1.
- Microtubule associated serine/threonine kinase 1.
- TATA-box binding protein associated factor 9.
- TATA-box binding protein associated factor 2.
- TAF7 RNA polymerase II, TATA box binding protein
Sequence:
MDGESSLERYLDQCDAEDVLASSAHMYTPMTPYDDLAIQPLPGTSYSSALEQSKELSTDFSSVDLSFLPDDLNQENEDQQEQQTSSQSLEQDSGICLDASNLSQPFTPSECRDASQDSTNLCPMPITPMTPMTPMTPVAESSGIVPQLQNIVSTVNLACKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVRFPIRLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKERSEIYEAFENIYPILKGFKKTT
Protein: 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) (Q9DCD0)
Organism: Mus musculus (Mouse)
Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- GDH/6PGL endoplasmic bifunctional protein
- Glucose-6-phosphate 1-dehydrogenase X
- Glucose-6-phosphate 1-dehydrogenase 2
- Transaldolase
- 6-phosphogluconolactonase
- Ribose-5-phosphate isomerase
- Ribulose-phosphate 3-epimerase
- Transketolase
- Probable gluconokinase
- Transketolase-like protein 2
Sequence:
MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILKYRDTDGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQDSWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFIHTNWTGHGGSVSSSSYNA
Protein: Collar protein p132 (p132) (Tail protein p132) (Q7Y5D9)
Organism: Escherichia phage T5 (Enterobacteria phage T5)
Function: Assembles together with pb1 to form the three L-shaped long tail fibers and probably the collar structure at the junction between the tail tube and the conical tail tip. Each fiber consists of a thin proximal rod of about 30 nm connected by a hinge to a thicker distal part of about 47 nm.
Subcellular location: Virion {ECO:0000269|PubMed:24198424, ECO:0000269|PubMed:36961893}. Note=Component of the tail (PubMed:24198424, PubMed:36961893). Assembles as a dodecamer surrounding the baseplate tube protein p140 trimer (PubMed:36961893). {ECO:0000269|PubMed:24198424, ECO:0000269|PubMed:36961893}.
Interaction partners:
Sequence:
MSTENRVIDLVVDENVPYGLLMQFMDVDDSVYPSTSKPVDLTDFSLRGSIKSSLEDGAETVASFTTAIVDAAQGVASISLPVSAVTTIASKASKERDRYNPRQRLAGYYDVIITRTAVGSAASSFRIMEGKVYISDGVTQ
Protein: Prostaglandin reductase-3 (PTGR-3) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 2) (Q8BGC4)
Organism: Mus musculus (Mouse)
Function: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Subcellular location: Peroxisome {ECO:0000269|PubMed:19091015}.
Interaction partners:
Sequence:
MLRLAAAGARAIVDMSYARHFLDFQGSAIPRTMQKLVVTRLSPNFHEAVTLRRDCPVPLPGDGDLLVRNRFVGINASDINYSAGRYDPSLKPPFDIGFEGIGEVVALGLSASARYTVGQAVAYMAPGSFAEYTVVPASIAIPMPSVKPEYLTMLVSGTTAYLSLEELGELSEGKKVLVTAAAGGTGQFAVQLSKIAKCHVIGTCSSDEKAAFLKSIGCDRPINYRTEPVETVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGRLIVIGFISGYQSPTGLSPIKAGVLPTKLLKKSASLRGFFLNHYFSKYQAAMERLLELYARGDLVCEVDLGHLAPDGRFIGLESVFQAVDYMYTGKNTGKLVVELPHPVSSKL
Protein: Transcription initiation protein SPT3 homolog (SPT3-like protein) (O75486)
Organism: Homo sapiens (Human)
Function: Probable transcriptional activator.
Subcellular location: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9726987}.
Interaction partners:
- Transcriptional adapter 2-alpha
- Transcription initiation factor TFIID subunit 9
- Transformation/transcription domain-associated protein
- SAGA-associated factor 29
- Transcription factor SPT20 homolog
- TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
- Histone acetyltransferase KAT2B
- STAGA complex 65 subunit gamma
- TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
- Transcription initiation factor TFIID subunit 12
Sequence:
MNNTAASPMSTATSSSGRSTGKSISFATELQSMMYSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDEDDLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCSSMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRIGPLSPFTNAYRRNGMAFLAC
Protein: Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C] (Q9CR35)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space {ECO:0000250}.
Interaction partners:
- Carboxypeptidase A1
- Bile salt-activated lipase
- Carboxypeptidase B
- Anionic trypsin-2
- Chymopasin
- Chymotrypsin-like elastase family member 3B
- Trypsin-5
- trypsin
- Pancreatic triacylglycerol lipase
- Chymotrypsin-like elastase family member 2A
Sequence:
MAFLWLVSCFALVGATFGCGVPAIQPVLTGLSRIVNGEDAIPGSWPWQVSLQDRTGFHFCGGSLISENWVVTAAHCGVKTTDVVVAGEFDQGSDEENVQVLKIAQVFKNPKFNSFTVRNDITLLKLATPAQFSETVSAVCLPTVDDDFPAGTLCATTGWGKTKYNALKTPDKLQQAALPIVSEAKCKESWGSKITDVMICAGASGVSSCMGDSGGPLVCQKDGVWTLAGIVSWGSGFCSTSTPAVYARVTALMPWVQEILEAN
Protein: Myo18b protein (B7ZNF7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
ELDQAEDLASLVSVNESSVMNTLLQRYRAQLPYTCSGPDLITLQPQTTTVPSSGKVPRGRQDGLPAHVTSLAQRAYWALLSQRRDQSIVALGRSGAGKTTCCEQVLEHLVGMAGSVDGRVSVEKLRATFTVLRAFGCVSTGHSRRATRFAMVMSLDFNATGRVTAAQLQTVLLENSRVARQPQGEGNFEVFSQLLAGMDVDLRTELNLHQMAESSAFGMGLWSKPEDKQKAATAFSQLRGAMELLGISEGEQQAIWRVLAAIYHLGAAGACKVGRKQFMRFEWANHAAEALGCDYEELNTATFKHHLRQIIEQMTSGPQRQGLQDNEACSGLKMTGVECVEGMASGLYQELFVAVVSLINRSFSSHHLSMASIMVVDTPGFQNPRHQGKDRAATFEELCYNYAQERLQLLFYHRTFVSTLERYKEEGIPVPFDLPESSPGTTVAVVDQNPSQVHLPAGRGAEDAGGLFWVLDEEVRVQGSSDSTVLERLRAAFEKKKEAGAEEPPSMRTCEQPLQCELFHQLGRDPVRYDLTGWLRRAKPNLAALEAPQILQQSKREELQSLFQARAKLPPVCRAVAGLEGTSQQALHRSRVVRRAFASSLAAVKRKAPCAQIKLQMDALISLLRRSRLHFIHCLVPTTVESKAGQRTPSPSQPSGDQGVANEPTALDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRRFQVLDPALLKKLDLTSEELDERKVVEELLQTLDLEKKAVAVGHSQVFLKAGVVSRLERQREKLVSRNIVLFQAACRGFLSRQEYKKLKIRRLATLCIQKNLAVFLKVKDWPWWGLLASLRPLLSSTLGTEQLRAKEEELTLLRQKLQKSENSRSELRQNADLLESKITDLTSELADERFKGDVACQALESERAERLQALREVQELKTKYQQVQDALGEVQKQVEEAQQRIQGANLEEKPAGGADEWQMRLDCAQMENDFLRKRLQQCEERLDSEMKARTELEQKLGELQSAYEEAKKMAHQLKRKCHHLTWDLEDTRVLLENQQSRNHELEKRQKKFDLQLAQALGESMFEKSLREKVSQENNGVRWELGQLQQQLEQKEQEASKLKQEVERLQGQKRELLSCASVGDQGVASLKERVWELETNALEQQKIHSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLRQLEMQLEQEYEEKQVALHEKHDLEGLIGTLCDQIGHRDFDVEKRLRRDLRRTHALLSDVQLLLATIEDSKTSISKEELEKVHSQVSAVSSEGDGLFWETAQGFPRPSGRWRNGLGTHLAMEGKGQDMLTSVGWSQLCLFGGHEQIMSGTNWLRLVCESEWMLGLGIEDNC
Protein: inositol-polyphosphate 5-phosphatase (EC 3.1.3.56) (Q385E2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Phosphoinositide phospholipase C
- 3'
Sequence:
MRSLLEGITSTLRSAQQHQTGWDPRNATSTGVPTTAQEAFSGGVPAVAQRDLSHVEGPVSSKGGAPMDCITGYSRFSTHSPPDFPFRMLMITQNVGAIGDTAAGAKEGGEEHRRECEKQAGNDELSSDAQKDVREFLSELRLLIFEYSRREYTAHIRVSNTGDDDPSHPSAADIGGQGPPPLIDVIVVHFQEIGGKSFHTEFNNYFANALQELLPEAGWTSGLLMRANDDEDQFTAVGSVVYLSHRMCPISSILSFHHRTFVCVGDDPVTYGSSPTILFHGGKFSGAGESRKGYLLISLRLGTVVVNFLNVHLYNDKKSKEAAAASPSPYALQRQEALLETLAECAAFISPDDPLFIFGDFNTRLDVHNMLQYLKEVENLDVKVSDGDVRAPDSFWELFENPQHMGVIRPYDVEVQRLLDVVAQQSGMELAEFAVRFPPTYLCQSPRDSEEATFQIDTPVHLVNDGEDKRESGTSDRISVVRVLERLSSIPHHPYGRRRVPAWCDRVLWNPPALELMTGRRTSQSVAGSSATAHGGTGVGALRRYVYRSVALRHTDHAAVTLFF
Protein: Cngb1 protein (Q80XL8)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
EEEPIVLLDSCLVVQADVDECQLERTPSELASIQELPEEKEEKEEEKEEEKEEEEEKKEEEVEKKEEGEATNSTVPATKEHPELQVEDTDADSGPLIPEETLPPPERPPPSPVKSDTLTVPGAAAAGHRKKLPSQDDEAEELKALSPAESPVVAWSDPTTPQEADGQDRAASTASQNSAIINDRLQELVKMFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPDPAQKPAEAEVAEEEHYCDMLCCKFKRRPLKMYRFPQSIDPLTNLMYILWLFFVVLAWNWNCWLIPVRWAFPYQRADNIHFWLLMDYLCDFIYLLDITVFQMRLQFVKGGDIITDKKEMRNNYLKSRRFKMDLLCLLPLDFLYLKLGINPLLRLPRCLKYMAFFEFNNRLEAILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAFQGIGSTHWVYDGVGNSYIRCYYWAVKTLITIGGLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYSIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKAVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRNNNKPKEEKSVLILPPRAGTPKLFNAALAAAGKMGPRGAKGGKLAHLRARLKELAALEAAARQQQLLEQAKSSQEAGGEEGSGATDQPAPQEPPEPKDPPKPPGPPEPSAQSSPPPASAKPEESTGEAAGPPEPSVRIRVSPGPDPGEQTLSVEVLEEKKEGAE
Protein: Anti-sigma factor (PrsH protein) (Q9R3X8)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Interaction partners:
- RNA polymerase sigma factor
- Anti-sigma-B factor antagonist
- Uncharacterized protein ushY
- RNA polymerase sigma factor
- RNA polymerase sigma factor
- RNA polymerase sigma-F factor
- RNA polymerase sigma factor sig8
- RNA polymerase sigma factor
- RNA polymerase secondary sigma factor
- Regulatory protein
Sequence:
MSQIAGEPATQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDEIEDLRIAVDEACAILLQQAVPGSVLSCVFRLVDDSLEVTVSAPTTDGHAPSRDTFAWTVLSALAGKVSSAVDEDKTVSISLYKQRGAGPGPT
Protein: Sigma-54 dependent transcriptional regulator (Q9KU59)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- Aerobic respiration control sensor protein
- histidine kinase
- Sensory histidine kinase/phosphatase NtrB)
- Pyruvate-flavoredoxin oxidoreductase
- MinD-related protein
- histidine kinase
- RNA polymerase sigma-54 factor
Sequence:
MSTQFRMDSVPGSLVVVGGTYEPWLAVLEKVGWRCTQVADLRKADALFVETGPCIGIVDLSHDEFSLNGIANLVSSHKQVRWLAFIREAQLSSDTICQFIVNFCIDFFTAPIPDAQLLSTIGHQLGMLKLEKKVWPHFGSAGNMGLIGESMPMKRLRDQIKRIGPTDVSILIYGESGTGKETVAKAIHKTSSRAQKPFISVNCRAMSEKRLESELFGLGETEEGQQPFLLQADGGTLLLNDILTLPKSQQLNLLRFLQEGTVETRQGVRAVDVRILAANSSDIEKALIDGDFNEELYHYINVLRINVPSLKERASDIVLLAKHFLQEYSKEYNAQARSFSDDAVRGLTRYHWPGNVRELMNQIKRVVLMSDTVVLDESQLDLPKRSDGRRSLKSIRERSERDALLLVLESHSGQVSTAAKELGVSRATMYRLLNKHNLITDENF
Protein: Methionyl-tRNA formyltransferase (EC 2.1.2.9) (Met-tRNA(fMet) formyltransferase) (P23882)
Organism: Escherichia coli (strain K12)
Function: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Interaction partners:
- Peptide deformylase
- Ribosomal RNA small subunit methyltransferase B
- Methionine--tRNA ligase
- Bifunctional protein FolD
- Phosphoribosylglycinamide formyltransferase
- Serine hydroxymethyltransferase
- Aminomethyltransferase
- Dihydrofolate reductase
- Methionine synthase
- Trk system potassium uptake protein TrkA
Sequence:
MSESLRIIFAGTPDFAARHLDALLSSGHNVVGVFTQPDRPAGRGKKLMPSPVKVLAEEKGLPVFQPVSLRPQENQQLVAELQADVMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRGAAPIQRSLWAGDAETGVTIMQMDVGLDTGDMLYKLSCPITAEDTSGTLYDKLAELGPQGLITTLKQLADGTAKPEVQDETLVTYAEKLSKEEARIDWSLSAAQLERCIRAFNPWPMSWLEIEGQPVKVWKASVIDTATNAAPGTILEANKQGIQVATGDGILNLLSLQPAGKKAMSAQDLLNSRREWFVPGNRLV