wanglab/gogpt-training-data huggingface dataset:
Protein: tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (Q8IAR7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Tyrosine--tRNA ligase
- glycine--tRNA ligase
- tryptophan--tRNA ligase
- leucine--tRNA ligase
- Isoleucine--tRNA ligase, putative
- isoleucine--tRNA ligase
- threonine--tRNA ligase
- leucine--tRNA ligase
- Proline--tRNA ligase
- Proline--tRNA ligase, putative
Sequence:
METTDTKREEQEIEEKKAQEESKIEDVDKILNDILSISSECIQPDELRVKLLLKRKLICYDGFEPSGRMHIAQGLLKSIIVNKLTSNGCTFIFWIADWFAHLNNKMSGDLKKIKKVGSYFIEVWKSCGMNMENVQFLWASEEINKKPNEYWSLVLDISRSFNINRMKRCLKIMGRSEGEENYCSQILYPCMQCADIFFLNVDICQLGIDQRKVNMLAREYCDIKKIKKKPVILSHGMLPGLLEGQEKMSKSDENSAIFMDDSESDVNRKIKKAYCPPNVIENNPIYAYAKSIIFPSYNEFNLVRKEKNGGDKTYYTLQELEHDYVNGFIHPLDLKDNVAMYINKLLQPVRDHFQNNIEAKNLLNEIKKYKVTK
Protein: Acetyl-CoA carboxylase (H2L0M0)
Organism: Caenorhabditis elegans
Interaction partners:
- Fatty acid synthase
- Acetyl-CoA acetyltransferase homolog, mitochondrial
- Malonyl-CoA decarboxylase
- [acyl-carrier-protein] S-malonyltransferase
- Bifunctional glyoxylate cycle protein
- BPL/LPL catalytic domain-containing protein
- Acetyl-CoA C-acetyltransferase
- Acetyl-coenzyme A synthetase
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- 2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein
Sequence:
MPFRSENGSQQAPAAAQRRKPSLVYGQFSQEITAAKPPPWSITFSDGAEDNQEKPPVDSICDVAIDFESATLESINYVELLGVLGLPFTSSVCQVSINFSQQVTDLGRAFTMVVNGQKPDIRTIVVSGNSLTNDAADQYESMEQFIHSHVADIEKRRPIKRLLVATNGIAAMRCLMTAKKFLHHTFRNDNLIHFVCMTTEDEIQSMSESLRMPNITLAESPSGTNKNNFANVDEILKHAIKYEVDAVWAGWGHASENPDLPRRLNDHNIAFIGPPASAMFSLGDKIASTIIAQTVGVPTVAWSGSGITMESIERSRGDFVVVPEDLLEQACVANYKEGLEALKTHNIGFPLMIKASEGGGGKGIRKCTKVEDFKSMFEEVAQEVQGSPIFLMKCVDGARHIEVQLLADRYENVISVYTRDCSIQRRCQKIIEEAPAIIASSHIRKSMQEDAVRLAKYVGYESAGTVEYLYLPASEGQEEHYYFLELNPRLQVEHPTTEMVSNISIPAIQLQIAMGLPLHKIKDIRKLYDLPIDGDSELPDEVLVDTKLHAIAARITCENPDDSFRPSTGKVYEINFPSSQDAWAYFSVGRGSSVHQFADSQFGHIFTRGTSRTEAMNTMCSTLKHMTIRSSFPTQVNYLVDLMHDADFINNAFNTQWLDKRIAMKIKQKCSLSMSVIIAVSAAVIGSSRVTGVFESFEESIDRGQVRPPNDLTETFIFDLVKDLNIYSLKVVRSAENTFVIILNGSKVTVGVKELQNGEFMVTHCEIVYRCAFEETKEAYKVTVNNEIITFEKDNDVSVLKSPYTGKLLQWKKEDGDWLNVGDVYATAESMKMVFQVEVAKAPGRLQRVVNEGDPIHPGSVLAKLVDQTESEADRAQPFHGTFLEWSWHSSKANEQSKFNDCLAQCQNLLAGSTPMDSACIITELFHHLNESHTAHASEVLNQLLRDYINVEKYFEGKVYDDSVGEIKEDHLSRKDVVRTIYSHTQIKSKNIVMKALLGALKQGSGSKFIPSLLDNLRQIGNLHHTEEISNLAREILLFYHSMCYKNNYSEITASGLRPTGQEVKAWLDGPLSRRPDSSGWKVIHEYFFDETIGSQCLDRYVAMHISAEEGSIGNTYPLPQMKCTIDHFTLTATPKSFNKVVLKGNKLIVVRLSLDSKTFNQQCFSSEKFLDCLKTNFRKYCKKTDVINVSIFVKITDDLEAHQDPSTLTEQEEQRVCYAQNAVVDMKTILEKEFRVNRVNTVLCLNDRPLPQLTIFEQVRLEKDRLPANSYPVLSKLSTVRVSQHDDPTSNFAKLFVRQQLIIPGNNAEEVQKKISQAVYLALDNACTAAQVAMAKKTKANKTFTSNHVFVFISCPGLPEKVIGSQEQLEFMKKCITDEVDSHKAILAKHQINEVEVVYESVDGHKRIVIRDETGVTTEVITEFSEASLGVYPVINTIEKKRLAARRVNSSYIYDFPIIFGMAAMNFWKSASSAMELPNEMAQALKEQRWREFFQIRELVLENGVLTEISDAEILKKRSANALNNCGMVAWIMTLYTPEKPRGFDLIVIGNDVTFQSGSFGTAEDDLFAAASTYSREHKLPRVNVSVNSGARIGLSTKISKLVKLQLENEDKPEQGFEYIYIDGEHKAQIEGEVVYEELGNGRLKILAVIGAKNEKIGVENLQGSGLIAGETARAYAEVPTYCYVTGRSVGIGAYTARLAHRIVQHKQSHLILTGYEALNTLLGKKVYTSNNQLGGPEVMFRNGVTHAVVDNDLEGIAKVIRWMSFLPTPTEEFPFFSKHGDDCSARDVVIPSDSEQNTYDVRDLIDSKNLSNQTGICDTMSFDEICGDWAKSIVAGRARLCGIPIGVVSSEFRNFSTIVPADPAIDGSQVQNTQRAGQVWYPDSAFKTAEAINDLNKENLPLMIIASLRGFSGGQKDMYDMVLKFGAQIVDALAVYNRPVIVYIPEAGELRGGAWAVLDSKIRPEFIHLVADEKSRGGILEPNAVVGIKFRKPMMMEMMKRSDPTYSKLSSSTEPEAREQLEERYEELSKTYRNASVEFADAHDRWQRMKSVGVVEHVTSLTNSRRLFSELLRNELAKVGMAEIYSSAPHTVKPCLATAMTWVETNLRSYVQPNSSMDEQYTQIEQYYETQFVDDLVIAINEDRKRYEQQLNTFMNKISSKRR
Protein: Protein-lysine methyltransferase METTL21C (EC 2.1.1.-) (Methyltransferase-like protein 21C) (Q8BLU2)
Organism: Mus musculus (Mouse)
Function: Protein-lysine methyltransferase.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q5VZV1}. Cytoplasm {ECO:0000250|UniProtKB:Q5VZV1}.
Interaction partners:
- EEF1A lysine methyltransferase 2
Sequence:
MDQHLHIAQQPLLSGTPQEDGFAGPSVEFDRIESSLRSIQKFVPTDYASYTQEHYQFAGKKIIIQESIENYGTVVWPGATALCQYLEDHTEELNLQDAKILEIGAGAGLVSIVSSLLGAQVTATDLPDVLGNLQYNILKNTLECTAHLPEVRELVWGEDLEQSFPKSTCCYDYVLASDVVYHHYFLDKLLATMVYLSQPGTVVLWANKFRFSADYEFLGKFKQAFDTTLLAEYSESSVKLFKGILKWE
Protein: Receptor like protein 23 (AtRLP23) (O48849)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the perception of necrosis and ethylene-inducing peptide 1-like proteins (NLPs), that act as extracellular signals mediating immune activation. Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
- Protein LYK5
- LysM domain-containing GPI-anchored protein 3
- Receptor-like serine/threonine-protein kinase SD1-7
- Elongation factor Tu, chloroplastic
- LysM domain-containing GPI-anchored protein 1
- Aspartyl protease AED1
- Probably inactive leucine-rich repeat receptor-like protein kinase At5g48380
- Chitin elicitor receptor kinase 1
- Precursor of elicitor peptide 1
Sequence:
MSKALLHLHFLSLFLLCCVCHSSIFTLNFHFTGIVACRPHQIQAFTKFTNEFDTRGCNNSDTFNGVWCDNSTGAVAVLQLRKCLSGTLKSNSSLFGFHQLRYVDLQNNNLTSSSLPSGFGNLKRLEGLFLSSNGFLGQVPSSFSNLTMLAQLDLSYNKLTGSFPLVRGLRKLIVLDLSYNHFSGTLNPNSSLFELHQLRYLNLAFNNFSSSLPSKFGNLHRLENLILSSNGFSGQVPSTISNLTRLTKLYLDQNKLTSSFPLVQNLTNLYELDLSYNKFFGVIPSSLLTLPFLAHLALRENNLAGSVEVSNSSTSSRLEIMYLGSNHFEGQILEPISKLINLKHLDLSFLNTSYPIDLKLFSSLKSLRSLDLSGNSISSASLSSDSYIPLTLEMLTLRHCDINEFPNILKTLKELVYIDISNNRMKGKIPEWLWSLPLLQSVTLGNNYFTGFQGSAEILVNSSVLLLYLDSNNFEGALPDLPLSIKGFGVASNSFTSEIPLSICNRSSLAAIDLSYNNFTGPIPPCLRNLELVYLRNNNLEGSIPDALCDGASLRTLDVSHNRLTGKLPRSFVNCSSLKFLSVINNRIEDTFPFWLKALPNLQVLTLRSNRFYGPISPPHQGPLGFPELRIFEISDNKFTGSLPPNYFVNWKASSRTMNQDGGLYMVYEEKLFDEGGYGYTDALDLQYKGLHMEQAKALTSYAAIDFSGNRLEGQIPESIGLLKALIAVNISNNAFTGHIPLSMANLENLESLDMSRNQLSGTIPNGLGSISFLAYINVSHNQLTGEIPQGTQITGQSKSSFEGNAGLCGLPLKESCFGTGAPPMYHQKQEDKEEEEEEEEEEEEVLNGRAVAIGYGSGLLLGLAIAQVIASYKPEWLVKIIGLNKRRKR
Protein: PTK2 protein (I6L996)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MKYQEVRCLTSFNISVSFPAETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLKPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRRH
Protein: T-box protein 2 (Q19691)
Organism: Caenorhabditis elegans
Function: Involved in the transcriptional regulation of genes required for the development of pharyngeal muscles derived from the ABa lineage. Acts as a transcriptional repressor and binds to T-box binding sites in its own promoter to negatively autoregulate its own expression in neurons, seam cells and the gut in order to restrict its expression to certain tissues. May function together with the nfya-1-NF-Y complex to repress its own expression. Plays a role in neural fate specification in the hermaphrodite-specific neuron (HSN)/PHB neuron lineage, acting in concert with homeobox protein egl-5 and the asymmetric cell division protein ham-1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201, ECO:0000269|PubMed:16701625}.
Interaction partners:
- Defective pharyngeal development protein 4
- Nuclear transcription factor Y subunit nfyb-1
- Homeobox protein ceh-22
Sequence:
MAFNPFALGRPDLLLPFMGAGVGGPGAGGPPPNLFFSMLQAGFPPGPVGSPPEDDGVTDDPKVELDERELWQQFSQCGTEMVITKSGRRIFPAYRVKISGLDKKSQYFVMMDLVPADEHRYKFNNSRWMIAGKADPEMPKTLYIHPDSPSTGEHWMSKGANFHKLKLTNNISDKHGYTILNSMHKYQPRLHVVRCADRHNLMYSTFRTFVFRETEFIAVTAYQNEKVTELKIENNPFAKGFRDAGAGKREKKRQLHRMNGDATQSPPGKTASLPTHSPHPSESNSEDDEPTLKKCKPEPSQTPTTSSLSTSTTPTLSAHHPLRSPQFCIPPPIDMMYQNMPMDLLAHWQMATLFPQFSMALNSPAAAASLLSKHLAKASSECKVEATSEDSEEAEKPEVKKEQKSVTPPKKGGFDVLDLLSKP
Protein: Very long chain fatty acid elongase 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Elongation of very long chain fatty acids protein 5) (Fatty acid elongase 1) (rELO1) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5) (Q920L7)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03205}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03205}. Cell projection, dendrite {ECO:0000255|HAMAP-Rule:MF_03205}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. {ECO:0000255|HAMAP-Rule:MF_03205}.
Interaction partners:
- Acyl-CoA
- Very-long-chain 3-oxoacyl-CoA reductase
- Very-long-chain enoyl-CoA reductase
- Very long chain fatty acid elongase 6
- Very-long-chain
- Very-long-chain
- Elongation of very long chain fatty acids protein 3
- Very-long-chain
- Very long chain fatty acid elongase 7
- Very-long-chain
Sequence:
MEHFDASLSTYFRALLGPRDTRVKGWFLLDNYIPTFVCSAIYLLIVWLGPKYMKNRQPFSCRGILVVYNLGLTLLSLYMFYELVTGVWEGKYNFFCQGTRSAGESDMKVIRVLWWYYFSKLIEFMDTFFFILRKNNHQITVLHVYHHATMLNIWWFVMNWVPCGHSYFGATLNSFIHVLMYSYYGLSSVPSMRPYLWWKKYITQGQLVQFVLTIIQTSCGVIWPCSFPLGWLYFQIGYMISLIALFTNFYIQTYNKKGASRRKEHLKGHQNGSMTAVNGHTNNFASLENSVTSRKQRKD
Protein: Numb (Q1XD15)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MNKLRQSFRRKKDVYVPESSRPHQWQTDEEAVRGGKCSFAVRYLGHVEVEESRGMHICEDAVKKLKTDRKVFKGFFKKAGKKAVRAVLWVSADGLRVVDDKTKDLILDQTIEKVSFCAPDRNFEHAFSYICRDGTTRRWICHCFMAIKDSGERLSHAVGCAFAACLERKQKREKECGVTATFDANRTTFTREGSFRVTTATEQAEREEVMRQLQDNKKDSDLVISSSSGGSCNPVVVTLAGPNGSSSPPLPMAPLGLQDGNPHVIPRRHAPVEALARQGSFRGFPALSQKTSPFKRQMSLRMNELPSTMQRKSDFPIKNTVPEVEGEVDSISSLCTQITSTFSGPPEDPFSSAPMPKPASSPQSPAAPVNGAVPAFPPPSVTVTTAANSPVLPPPPLPVRETNPWAKAPNTAPAHAAHTGSEWPSPSPSTGALPAVSATLSTPASAHKRTPSEADRWLEEVTKSVRAHQPAPTARTSTPPAQQPFPAPVPVPMPPSAPFMPPIPPSAVPSVPPRQPAFHAQAPVSFPVSNGIPYAQPTFPVVGITPSQMVANVFGSATQTQPISVPVPVAQTQLQSSPFSTPPATQFEPQPVCSPFGKPLLPPVPNTVVLQPPPKPSPAFNGANSWAAAASAGQAGANPPQADAFEAQWAALESRSQQRTAPSPTNPFSSELHKTFEIQL
Protein: Zinc transporter ZIP5 (Solute carrier family 39 member 5) (Zrt- and Irt-like protein 5) (ZIP-5) (Q6ZMH5)
Organism: Homo sapiens (Human)
Function: May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport (By similarity). Seems to play a central role in controlling organismal zinc status (By similarity). Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera. Plays a role in eye development.
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9D856}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9D856}. Note=Localized to the basolateral surfaces of enterocytes, pancreatic acinar and endoderm cells. During zinc deficiency diet, the basolateral cell membrane localization is lost in the intestine, the visceral yolk sac and acinar cell. During zinc repletion, is relocalized to the basolateral membrane of enterocytes, visceral endoderm cells and pancreatic acinar cells. Zinc can regulate the turnover of protein at the membrane. During zinc deficiency, is internalized and degraded in enterocytes, acinar cells and endoderm cells. Endocytosed through the endolysosomal degradation pathway RAB5A pathway. {ECO:0000250|UniProtKB:Q9D856}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A1
- Zinc transporter ZIP9
- Proton-coupled zinc antiporter SLC30A5
- Zinc transporter ZIP1
- Zinc transporter ZIP11
- Zinc transporter 7
- Zinc transporter 6
- Proton-coupled zinc antiporter SLC30A2
- Probable proton-coupled zinc antiporter SLC30A4
- Calcium/manganese antiporter SLC30A10
Sequence:
MMGSPVSHLLAGFCVWVVLGWVGGSVPNLGPAEQEQNHYLAQLFGLYGENGTLTAGGLARLLHSLGLGRVQGLRLGQHGPLTGRAASPAADNSTHRPQNPELSVDVWAGMPLGPSGWGDLEESKAPHLPRGPAPSGLDLLHRLLLLDHSLADHLNEDCLNGSQLLVNFGLSPAAPLTPRQFALLCPALLYQIDSRVCIGAPAPAPPGDLLSALLQSALAVLLLSLPSPLSLLLLRLLGPRLLRPLLGFLGALAVGTLCGDALLHLLPHAQEGRHAGPGGLPEKDLGPGLSVLGGLFLLFVLENMLGLLRHRGLRPRCCRRKRRNLETRNLDPENGSGMALQPLQAAPEPGAQGQREKNSQHPPALAPPGHQGHSHGHQGGTDITWMVLLGDGLHNLTDGLAIGAAFSDGFSSGLSTTLAVFCHELPHELGDFAMLLQSGLSFRRLLLLSLVSGALGLGGAVLGVGLSLGPVPLTPWVFGVTAGVFLYVALVDMLPALLRPPEPLPTPHVLLQGLGLLLGGGLMLAITLLEERLLPVTTEG
Protein: Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53) (P19397)
Organism: Homo sapiens (Human)
Function: Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:28487417}. Cell junction {ECO:0000250|UniProtKB:Q61451}. Membrane; Multi-pass membrane protein. Synapse {ECO:0000269|PubMed:35767951}. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000250|UniProtKB:Q61451}.
Interaction partners:
- T-cell surface antigen CD2
- Lysosomal-associated transmembrane protein 5
- CD82 antigen
- CD48 antigen
- Integrin beta-2
- Receptor-type tyrosine-protein phosphatase C
- Leukocyte antigen CD37
- Lymphocyte cytosolic protein 2
- TYRO protein tyrosine kinase-binding protein
- Uroplakin-1a
Sequence:
MGMSSLKLLKYVLFFFNLLFWICGCCILGFGIYLLIHNNFGVLFHNLPSLTLGNVFVIVGSIIMVVAFLGCMGSIKENKCLLMSFFILLLIILLAEVTLAILLFVYEQKLNEYVAKGLTDSIHRYHSDNSTKAAWDSIQSFLQCCGINGTSDWTSGPPASCPSDRKVEGCYAKARLWFHSNFLYIGIITICVCVIEVLGMSFALTLNCQIDKTSQTIGL
Protein: Protein phosphatase 1, regulatory subunit 9A (H3BJA6)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
SPEEPSAENQAMPKSHILSPRNEPLEDAEANVVGSERAQHQKKDLTGGDLTSPDASASSCGREVPEDSNSFESSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENNYYQPDMEYSEIVGLPEEEEIPANRKIKFSCAPIKVFNTYSNEDYDRRNDDVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTDGGAAQRDGRI
Protein: Outer dense fiber protein 4 (Outer dense fiber of sperm tails protein 4) (Testis-specific protein oppo 1) (hOPPO1) (Q2M2E3)
Organism: Homo sapiens (Human)
Function: Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Ciliary microtubule associated protein 1A
- Outer dense fiber protein 1
Sequence:
MDAEYSGNEFPRSEGERDQHQRPGKERKSGEAGWGTGELGQDGRLLSSTLSLSSNRSLGQRQNSPLPFQWRITHSFRWMAQVLASELSLVAFILLLVVAFSKKWLDLSRSLFYQRWPVDVSNRIHTSAHVMSMGLLHFYKSRSCSDLENGKVTFIFSTLMLFPINIWIFELERNVSIPIGWSYFIGWLVLILYFTCAILCYFNHKSFWSLILSHPSGAVSCSSSFGSVEESPRAQTITDTPITQEGVLDPEQKDTHV
Protein: Leucine-rich repeat receptor-like protein kinase PXC1 (Protein PXY/TDR-CORRELATED 1) (Q9SJQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Leucine-rich repeat receptor-like protein kinase involved in secondary cell wall formation in xylem fibers. May play a role in a regulatory network which also incorporates the TDR/PXY signaling pathway and regulates the maturation of interfascicular fiber cells. May promote the initiation of secondary cell wall deposition during the procedure of cell expansion.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Hydroxyproline-rich glycoprotein family protein
- Uncharacterized protein
- Uncharacterized protein
- CLAVATA3/ESR
- Rho GTPase-activating protein 5
- Sequence-specific DNA binding transcription factor
- AT3g52230/F4F15_340
- Zinc knuckle
- Protein IQ-DOMAIN 3
- Proline-rich family protein
Sequence:
MAAKPLLLPLLLLLHLSITLAQNDTNALTLFRLQTDTHGNLAGNWTGSDACTSSWQGVSCSPSSHRVTELSLPSLSLRGPLTSLSSLDQLRLLDLHDNRLNGTVSPLTNCKNLRLVYLAGNDLSGEIPKEISFLKRMIRLDLSDNNIRGVIPREILGFTRVLTIRIQNNELTGRIPDFSQMKSLLELNVSFNELHGNVSDGVVKKFGDLSFSGNEGLCGSDPLPVCTITNDPESSNTDQIVPSNPTSIPHSPVSVREPEIHSHRGIKPGIIAAVIGGCVAVIVLVSFGFAFCCGRLDRNGERSKSGSVETGFVGGGEGKRRSSYGEGGESDATSATDRSRLVFFERRKQFELDDLLKASAEMLGKGSLGTVYKAVLDDGSTTVAVKRLKDANPCPRKEFEQYMEIIGRLKHQNVVKLRAYYYAKEEKLLVYEYLPNGSLHSLLHGNRGPGRIPLDWTTRISLMLGAARGLAKIHDEYSISKIPHGNIKSSNVLLDRNGVALIADFGLSLLLNPVHAIARLGGYRAPEQSEIKRLSQKADVYSFGVLLLEVLTGKAPSIFPSPSRPRSAASVAVEEEEEAVVDLPKWVRSVVKEEWTAEVFDPELLRYKNIEEEMVAMLHIGLACVVPQPEKRPTMAEVVKMVEEIRVEQSPVGEDFDESRNSMSPSLATTDG
Protein: Serine/threonine kinase NLK (EC 2.7.11.24) (Loss of intestine protein 1) (Nemo-like kinase) (Q9U9Y8)
Organism: Caenorhabditis elegans
Function: Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T-cell division asymmetry. Component of the beta-catenin-lit-1 complex which promotes the phosphorylation, down-regulation and subcellular relocation of pop-1. Regulates plp-1 nuclear localization in embryos. Plays a role in male tail tip morphogenesis.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:15066285, ECO:0000269|PubMed:16077003}. Nucleus {ECO:0000269|PubMed:15066285, ECO:0000269|PubMed:16077003, ECO:0000269|PubMed:21408209}. Note=Located in the anterior cell cortex before and during asymmetric cell division. After division, located preferentially in the nucleus of the posterior daughter cell. Localizes to the nucleus in hyp9 and hyp10 cells prior to male tail tip morphogenesis (PubMed:21408209). {ECO:0000269|PubMed:15066285, ECO:0000269|PubMed:16077003, ECO:0000269|PubMed:21408209}.
Interaction partners:
- Protein pop-1
- Armadillo repeat-containing protein wrm-1
- Mitogen-activated protein kinase kinase kinase mom-4
- Mitogen-activated protein kinase kinase kinase
- Forkhead box protein O
- Beta-catenin homolog sys-1
- Protein mom-5
- Abnormal cell lineage protein 44
- Frizzled-4
- Protein mom-2
Sequence:
MVSWGRGKDAYYLYISREQEEDDDDSLSFYSSQKDTEDEFCGCLFPDPEIPGSSSSSGCSSSSTELYDLAAAHAALISRQQQILSQAIPIIPEHQLAAVAAHHQHHQQLHPSVQYQLVAAATHHNHHQPQAAQPHYSAVVPRSDVIQQPPHFALHHHLQNLVQQQQQQQAHHHHQQLVGEMALVSHTHPAAVGSTTCYEKNQQKQQQVQQIPTQPQVAHVSSNAILAAAQPFYPPPVQDSQPDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEEGRLRFHSCMCSCCYTKPNMPSRLFAQDLDPRHESPFDPKWEKDMSRLSMFELREKMYQFVMDRPALYGVALCINPQSAAYKNFASSSVAQASELPPSPQAW
Protein: Single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein) (P0AGE0)
Organism: Escherichia coli (strain K12)
Function: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. Acts as a sliding platform that migrates on DNA via reptation. SSB or its 10 C-terminal amino acids stimulates the ATPase activity of RadD.
Interaction partners:
- DNA polymerase III subunit chi
- DNA polymerase III subunit alpha
- DNA polymerase III subunit tau
- Replicative DNA helicase DnaB
- ATP-dependent DNA helicase RecQ
- Replication restart protein PriA
- Beta sliding clamp
- DNA topoisomerase 1
- DNA primase
- DNA repair protein RecO
Sequence:
MASRGVNKVILVGNLGQDPEVRYMPNGGAVANITLATSESWRDKATGEMKEQTEWHRVVLFGKLAEVASEYLRKGSQVYIEGQLRTRKWTDQSGQDRYTTEVVVNVGGTMQMLGGRQGGGAPAGGNIGGGQPQGGWGQPQQPQGGNQFSGGAQSRPQQSAPAAPSNEPPMDFDDDIPF
Protein: Steroidogenic factor 1 (Nuclear receptor subfamily 5 group A member 1) (F1DAM0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
Protein: TRF-like 3 (F4I7K3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- SNF2 domain-containing protein / helicase domain-containing protein / zinc finger protein-like protein
- Zinc finger protein CONSTANS-LIKE 10
- Lycopene beta/epsilon cyclase protein
- Enhancer of polycomb-like protein
- Serine carboxypeptidase-like 49
- Transcription factor bHLH35
Sequence:
MFGNVKDYGETFQDSIFQTRNGSLSSTNQIGNPVTYKLVRVAGDGSLVPATDEEMLEVKNLLEKNEQDMPVLPDPIQTEEYIPDEGSPSQFLQLENFEGKTYCIHAKTDRISLGLHDKGFFQSETAGPYTENLNSRHESKEELMNGSQMLFVLPDTKFQISTELSGNVELVPSKVLLQEPILFSSNGCSINQSTDVLNATASPKEPALSTAASKPDFSRVPGEISLANLSIKELQETFRATFGRETTSKDKRWLKRRIKMGLINSCVVPTTTLTINDSKLIGGDQDAIDAFSKGTVDEETATESIDTPASPDGIKGHSNDFGHSPVETFVDHYSGNEDFEGEDGSAKRVRKPTRRYIEETNEKQQIDGSMIPSKDPSSIQAVSSEGRVVVTRMVSLAGSRIQVPYVSHVRRSRPRENIMALGEFRSKSWEVKAAPEEGNLNLSPPQLSNDVNRVPGVKSASRCVQKESDKDHLKPIFTDVDQEMMEPELLDSSGDSSDDNFVDAPITQSASGRKLHRAWTISEVEKLVEGVSKYGVGKWTEIKKLSFSPYTHRTTVDLKDKWRNLQKASSSNRMEGGLKKHGSMAIPTHIMLQVRELAQKQSPISRVVSKARVVKRSRSRNGFL
Protein: GH04846p (Ras-related GTP binding A/B) (Q9VHJ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH16429p
- Raptor, isoform B
- GATOR complex protein NPRL2
- GATOR complex protein Iml1
- GATOR complex protein NPRL3
- Folliculin
- Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
- Serine/threonine-protein kinase mTor
- Ragulator complex protein LAMTOR2 homolog
- Ragulator complex protein LAMTOR1
Sequence:
MKKKVLLMGKSGSGKTSMRSIIFANYIARDTTRLGATIDVEHSHVRFLGNLVLNLWDCGGQEGFMKQYFAQQRDNIFRNVEVLIYVFDVESQEIERDIHYYQSCLEALLQNSPEAKIFCLVHKMDLVPEGLRESVFTERMEDLIKLSKPGNVTCFRTSIWDETLYKAWSSIVTMLIPNVAALENSVTHFGNVIEADEVLLFEKATFLVISHCQSKKNRDSHRFEKVSNIIKQFKLSCSKLGAKFQSMEVRNSAFAAFIDTFTSNTYVMVVMSDPTLPSEATLVNIRNARKYFEELENPSNSAINHHGQRYH