wanglab/gogpt-training-data huggingface dataset:
Protein: RE05782p (Q8IGY5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
NYNVSYDETLVNQKNMEYQKRTPKRRSFIERAQKESEELVRTMGGSLELAGGRRTRSSTRGTPTRAAEAVTPPPSKKARTSPASATKASAGKGRGARKLDVGADEPEPELEKEKEKVQTSVKGKGAVKKDKKEVKKQEKATEKYAPEEAKEDVAEAKEEDASPAGVQDQPDGVENLPSVAEAKQNHVDEVKPISEEPGNSSEEVPKAEEPLKSSGETSENGAATETAAAPKEPASVMDVDEDETLVENTPSANKEKALDDEKEPEQKSEEHAAAVLESKEQNEPAKEPTPEPMEVDGSSKGSSDTAQVDTPAIENVSAAPETEAAAKTTESSNDVVEVATEGKETVLEVPAAEPKEAESTVESAEELTETSTVVVTEPKEAASSEEEPSKVVDSAEPKEAESNTDESATPVPIDVSTAPASNDVSKPLEIDTTLVKTADSPAKEPQEICEVKKAEINVNGEPKIVNSSAEVGENAAPKVCN
Protein: Coiled-coil domain-containing protein 39 (E2R1I5)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9UFE4}. Note=CCDC40 is required for localization to axonemes. {ECO:0000250|UniProtKB:Q9UFE4}.
Interaction partners:
- Glucosidase alpha, acid.
- Radial spoke head 9 homolog.
- Coiled-coil domain containing 65.
- Coiled-coil domain containing 103.
- Dynein axonemal assembly factor 3.
- Intraflagellar transport 122.
- Family with sequence similarity 227 member A.
- Dynein axonemal light intermediate chain 1.
- Dynein axonemal intermediate chain 2.
- Dynein axonemal heavy chain 5.
Sequence:
MSSELLEELHWDDGFAIPVANEENKMLEDQLSKLQEERASLQDQLRDYEDRINAMTSHFKNVKQEFSFTQSLCKAREHEIESEEHFKIIAERELGRIKDEIQRLENEMTSIREKKSDKENNIFKTTQKLDGLKCQINWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQRRKVLDNELTETLSAQLELDKAAQDFRKIHNERQELIKQWENTIEQMRKRDRDIDNGALALARIKQELREKENLVKEKIKFLESEIGNNTEYEKRISVADRKLLKCRTEYQHHETNRNQLKDELDSLKATVNRSSSDLEALRKNISKIKKDIQEETARLQKIKNHNQSVKKKLKQITEKTMSVEEKATNLEDMLREEEKSVKEVEVQLNIVKDVLFKKVQELQTEAMKEKAVVSEIEGTRSSLKHLNHQLHKLDFETLKQQEIMYSQDFYIQQVERRMSRLKGEINSEEKQALETKIVELKKILEEKKSTFDLLESQIKKLHNDLYFIKKSNSKNCDEKQFLMTKVNELNLFNDRSEKELNKTKALKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLHTAMEERMEEIKVHKTMLASQIRYIDQERQNLSAEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDSLDAKINKAEKEIYALENTLQVLRSCNNNYKQSFQKITPSSDEYELKIQLEEQKRAIDEKYRYKQRQIRELQEDIQSMENTLEVIEHLTNNVKEKLSEKQAYSSQLNRETEEQRPKLERVTKQCAKLTKEIRLLKDTKDETLEEQDIKLREVKHFHKIIDEMLAEVTEENAEIHIILQTYFQQNGLELPTAGTKGSRQSSRSPSQTSLLSARSTTSVASQTSIKVLELNFPASSSVTGNISRPASATTIPSNGKNKKGSK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q7Y229)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Rho GTPase-activating protein 5
- Protein IQ-DOMAIN 10
- CRIB domain-containing protein RIC2
- RING-type E3 ubiquitin transferase
- Fasciclin-like arabinogalactan protein 12
- RING-H2 finger protein ATL54
- Fasciclin-like arabinogalactan protein 11
- Chitinase-like protein 2
Sequence:
MGGDLKSQLSRESHVFGLKVWEVIGIAVALLIIAILSVLSCCLTSKKKSRRSKTGLPVIQTPPVVSKEIREVRVEHVSASNFAPGEGILLTIQDKNNKDSEKVMVHLDMRKKRSSSGRSGSFHHLEIIDKHSDSAEEVSASSSLYNIATPSPLSGLPESHLGWGHWFTLRDLETATNRFSKENVIGEGGYGVVYRGELMNGTPVAVKKILNQLGQAEKEFRVEVDAIGHVRHKNLVRLLGYCIEGTHRILVYEYVNNGNLEQWLHGAMRQHGYLTWEARMKVLIGTSKALAYLHEAIEPKVVHRDIKSSNILINDEFNAKVSDFGLAKLLGAGKSHVTTRVMGTFGYVAPEYANSGLLNEKSDVYSFGVVLLEAITGRDPVDYGRPAHEVNLVDWLKMMVGTRRSEEVVDPNIEVKPPTRSLKRALLTALRCVDPDSDKRPKMSQVVRMLESEEYPIPREDRRRSRTREGSMEINSDTDMSTPVSRSQSKRQ
Protein: Ceramide kinase-like (A2AQH1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MFRGRRRSRVGALEEAPPENPKAAAEPERVLLRGIFEIRRESCDVALGERALRWRRIQPELPAGGTRHDLLSKEESLELEDIFSVKLKRRCWAKHPGRDTLLGITLFICLKEQRNKLKDSTLDLINFSEDHCDIWFRQFKKILDGFTSRPKALKILLNPQSHRKESVHVYYEKVEPLLKLAGIETDVTITEYEGHALSLLDECELRGFDGVVCVGGDGSASEAARALLLRAQKNAGVEMDCIPTLVGAELPLGFIPAGSTNALAHSLFGTPHVVTATMHIILGHIRSVDVCTFSSAGKLLCFGFSAMFGFGGRTLALAEKYRWMSPSQRRDFAIIKALAKLKPEDCKISFLLAGCSQNKQERKSQRSAESDCGGHWQTIQGQFLNISIMAMPCPCSMAPRGFTPDTRLHNGSMALRVVRNTTRSEFVKHLKRHSSVKNQFNFPFVETYIIEEVKIHPKSNSNGYSPQEEGGNHTTASEHGFPWNVDGDLMEAASEVHIRLHPRLIRLYGGSLEEMNDCKVACDCI
Protein: Proprotein convertase subtilisin/kexin type 6 (H3BJL4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
NLGQIGNLDDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQARSDSLYFNDPIWSNMWYMHCTDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEAKSIPIVQVLRTTALTNACADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLLDFSNEGFTNWEFMTVHCWGEKAEGEWTLEVQDIPSQVRNPEKQGKLKEWSLILYGTAEHPYRTFSSHQSRSRMLELSVPEQEPPKAAGQPPQAETPEDEEEYTAPSIQGSPNTLQTSVCHPECGDKGCDGPNADQCLNCVHFSLGNSKTNRKCVSECPLGYFGDAAARRCRRCHKGCETCTGRSPAQCLSCRRGFYHHQETNTCVTLCPAGLYADESQRLCLRCHPSCQKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELVKCGECHHTCRTCVGPSREECIHCAKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCEENCLSCEGSSRNCSRCKAGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG
Protein: Ran-binding protein 9 (RanBP9) (A1L252)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P69566}. Cell membrane {ECO:0000250|UniProtKB:P69566}; Peripheral membrane protein {ECO:0000250|UniProtKB:P69566}; Cytoplasmic side {ECO:0000250|UniProtKB:P69566}. Nucleus {ECO:0000250|UniProtKB:P69566}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:P69566}.
Interaction partners:
- Armadillo repeat-containing protein 8
- E3 ubiquitin-protein transferase RMND5B
- GID complex subunit 4 homolog
- WD repeat-containing protein 26
- WD repeat domain 26a.
- Glucose-induced degradation protein 8-B homolog
- Glucose-induced degradation protein 8-A homolog
- Mkln1 protein
- Protein yippee-like
Sequence:
MSGPSSGCGFLMSVVVHGDLALNEQEKELNQRLRRLYPAVNEQETPLPRSWSPKDKFSYIGLSQNNLRVHYKGHGKTPKDAASVRATHPIPAACGVYYFEVKIISKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGIAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQSQIDRFPIGEREGEWQAMIQKMVASYLVHHSYCATAEAFAKSTDQAVHEELASIKNRQKIQKLVLSGRMGEAIETTQQLYPSLLERNPDLLFMLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPGSPRLFNSPVHKPSSSQAYQTGFDSNYCNGVSSSKGHTSAHSHKSCPPTLSSPELGVLNGSRGQQTIVSSEVEMEVDHFSNGVSESSSNGFLNGSSTHGTEQEDCDADMEVDSTQSKRQLCGGSQAAIERMIQFGRELQSMSEHLRRERGKNSANKKMLKDAFSLLAYSDPWNSPVGYQLDSIQREPVCSTLNSAILETHNLPKQPPLALAMGQAAQCLSLMARTGSGSCAFASVDDYLH
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Q94774)
Organism: Trypanosoma brucei brucei
Interaction partners:
Sequence:
MSYRPHHATVPTNPKVYFDVSIAGQAAGRITFELFADAVPKTAENFRALCTGEKGFGYAGSGFHRIIPQFMCQGGDFTRHNGTCGKSIYGEKFPDESFAGKAGKHFGAGTLSMANAGPNTNGSQFFICTAPTQWLDGKHVVFGQVLEGMDVVKAMEAVGSQGGSTSKPVKIDSCGQL
Protein: Soluble guanylate cyclase 89Db (EC 4.6.1.2) (Q9VEU5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Heterodimers with Gyc88E are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Head-specific guanylate cyclase
- Soluble guanylate cyclase 89Da
- Guanylate cyclase soluble subunit beta-1
- Soluble guanylate cyclase 88E
- Inosine triphosphate pyrophosphatase
- Bis
- Molybdenum cofactor biosynthesis protein 1
- GTP cyclohydrolase 1
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11
- cGMP-specific 3',5'-cyclic phosphodiesterase
Sequence:
MYGMLYESVQHYIQQEYGMETWRKVCQIVDCKHQSFKTHQIYPDKLMPDFAAALSASTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTNMDDDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVMKKVKAHALPGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWLLEGPE
Protein: Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) (A0A1D8PGI8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Pentafunctional AROM polypeptide
- Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
- Chorismate synthase
- aromatic-amino-acid transaminase
- Anthranilate phosphoribosyltransferase
- Chorismate mutase
- prephenate dehydratase
- Tryptophan synthase
- anthranilate synthase
- histidinol-phosphate transaminase
Sequence:
MFITNEHVGDRSRMEDWRIRGYDPLTPPDLLQHEYPLTPESQKIIVEGRNAACDILNGKDDRLIIVIGPCSIHDPQAALDYCERLYQASEKHKGELLIVMRAYLEKPRTTVGWKGLINDPDIDGTFHINKGLRIARKLFVQLTSKLPIAGEMLDTISPQFLSDLFSVGAIGARTTESQLHRELASGLSFPVGFKNGTDGTLGVAIDALRAASHPHHFLSVTKPGVVAIVGTDGNQDCFVILRGGKKGTNYDAKSVQETQEELIKSKVVTESKPGPRIMVDCSHGNSNKDHRNQPKVAQVVAEQVAGGDKSICGLMIESNINDGRQDVPPKEQGGKDALKYGVSITDACIGWETTEEVLEVLANAVKTRRSL
Protein: SSD domain-containing protein (P91346)
Organism: Caenorhabditis elegans
Interaction partners:
- Helix-loop-helix protein 17
Sequence:
MRLGFGCLEPKAAKFFHSYGLLVSGYPFIFLVSPILVTCFLATGLIGLEPLSDALYLYTPTDAPSKTERRIIHDAWPLVDGTFVAGRAVTQSREVQVAVVARSGGNILDRVFSNELKLMESFIRNNITVQFSNRTWSFADLCLAGPDGRCANNDHIQLASRLHQHGINITYPTVRLSDKSAYIASALGGVKLAKGDNGENIIVEATAWLLIYQLKFYPNEISYVSGLWEREFKNKMDEYKKQAKYISITYFHSQTLSDELNRNAERLAPKFIGAFVILVCFSVLCSIVTIKGSGYIDWVVTKPILSVLGVSNAGMGIASAMGMLTYLEIQYNDIIAVMPFLVVAVGTDNMFLMVASLKRTDRNLKYDQRIAECMADAAVSILITALTDALSFGVGTITTIPAVQIFCIYTMCALLLTFAYQLTFFCAILVYYTRIEEQGLHSIWLRPAVTYSSTSPLNVKLFWLGSQPQKPLPSCGTVSSTSSVSTMTSQATSPASKHLHHCAATSFFRNWYAPVLMQPWIRAIAGLWYLIYLGISIYGCTHLKEGLEPANLLVDDSYATPHYRVLEKHYWHYGASLQIVVSNPPDLRDPVERINMDKMASTFANCKVAIGDDSVQFWLREMQVSEEIHKIQYDNEKFYDHAAQYIYSDMSQPWVVDVVWGRNNNSERIIKTFRFMIGMRDISTTTKQTEATNTFREIASRFEQYNVTTYMPLWLFTDQYALVVPNTMQDIIVAVACMLVISALLIPQPVCSFWVAVTIGSIDLGVLGFMTLWNVNLDAISMITIIMSVGFSVDYSAHITYAYVISKESTTSARVCDALGDLGWPVAQGAMSTILAVSVLSDVPAYMIVTFFKTVFLAISIGFLHGLVFLPLMLSVFVGCCSSNKIETKSVKEPRFVGRY
Protein: UDP-glucuronosyltransferase (EC 2.4.1.17) (Q93242)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|RuleBase:RU362059}; Single-pass membrane protein {ECO:0000256|RuleBase:RU362059}.
Interaction partners:
- Probable aldehyde oxidase gad-3
- Beta-glucuronidase
- UDP-glucose 6-dehydrogenase
- Inositol oxygenase
- alcohol dehydrogenase
Sequence:
MQLLSALLLQILFNVSSPYKILVYSNLFGHSHIKFVGSVVDTLVDAGHDVTVVLPVIDSTQKNRTSIKSGAKQIIIDADEEVVEIFSQTEKFLSNMWTMEMSNPLMMWMNPRILTQLFGKQCTKVMKLSELLDQLKSEKFDLAITEAFDSCGYGIFEYLQIPAHVSILSCARMDHVSDVLGQPIAPSYVPGTQSLYSDRMTMTQRFLNYLQFLNGNSMFSDIGDYESANAKKLLGVERSWREILPESSFLLTNHIPVLEFPAPTFDKIVPIGGISVNKNKETLKLEHYFDTMVSMRKKNVIISFGSNIKSMDMPDEYKKSLAELFQLMPDVTFIWKYENLADKKYTCGIMNINRVEWIPQTELLADSRVDAFITHGGLGSVTELATMGKPAVVIPIFADQTRNAEMLKRHGGAEVLHKTDLANPETLRKTLRKVMDDPSYRQNAQRLAEMLNNQPTNPKETLVKHVEFAARFGKLPSMDPYGRHQNIIEYYNLDILAIATILLTLVVYLKIFAVGVVVRCCCGKKKVKFE
Protein: ribose-phosphate diphosphokinase (EC 2.7.6.1) (Q9VT33)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH23275p
- Adenine phosphoribosyltransferase
- Adenylosuccinate synthetase
- Adenylosuccinate lyase
- LD21421p
- Bifunctional glutamate/proline--tRNA ligase
- Ribulose-phosphate 3-epimerase
- GMP synthase
- Trifunctional purine biosynthetic protein adenosine-3
- Lysine--tRNA ligase
Sequence:
MPDKKCTENEQNDCVMPVRSANPIRARSLIRDNLEKQAGCLNLIHSRMPNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKLAGSEDNAESKKLAKKNYDWKFRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIPEWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAILVDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRDCPKIQCIDVSMMFAEAVRRTHNGESVSYLFSNVPY
Protein: Nucleolar protein 4 like (A0A087X0N3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPKPTLLLRGGWERERSPGDSELGRQFRDWCLRTYGDSAKTKTVTRSKYQRIAEVLQGGGGTGAGSGPAAGEKGKFQFWVRSKGFRLGSGREPKMGQVVYVPVKTGSGADGLSEPEGISLKRVAVVEDFFDIIYSMHVESSAEPGKAPKHAGQKKTYRAIAETYAFLPREAVTRFLMSCTECQKRMHFNSNGLEPKENEPPSPLVSGIIDYNMPLTSTYLKQMKLRVMNSQEQDETSVSSEDFDMSDSTWMSADPHLASSLSPSQDERMRSPQNLHSQEDDDSSSESGSGNGSSTLNPSTSSSTQGDPAFPEMNGNGAVAPMDFTTAAEDQPINLCDKLPPATALGTASYPSDGCGADGLRSRVKYGVKTTPESPPYSSGSYDSIKTEVSGCPEDLTVGRAPTADDDDDDHDDHEDNDKMNDSEGMDPERLKAFNMFVRLFVDENLDRMVPISKQPKEKIQAIIESCSRQFPEFQERARKRIRTYLKSCRRMKKNGMEMTRPTPPHLTSAMAENILAAACESETRKAAKRMRLEIYQSSQDEPIALDKQHSRDSAAITHSTYSLPASSYSQDPVYANGGLNYSYRGYGALSSNLQPPASLQTGNHSNGPTDLSMKGGASTTSTTPTPTPSSTSTSRPVPTAQLSPTEISAVRQLIAGYRESAAFLLRSADELENLILQQN
Protein: Uncharacterized ferredoxin-like protein YdhX (P77375)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Putative cytochrome YdhU
- Uncharacterized oxidoreductase YdhV
- Uncharacterized protein YdhW
- Probable D,D-dipeptide transport system permease protein DdpC
- Uncharacterized protein YdhT
- Peptidoglycan L,D-endopeptidase MepK
- Uncharacterized ferredoxin-like protein YdhY
Sequence:
MSFTRRKFVLGMGTVIFFTGSASSLLANTRQEKEVRYAMIHDESRCNGCNICARACRKTNHVPAQGSRLSIAHIPVTDNDNETQYHFFRQSCQHCEDAPCIDVCPTGASWRDEQGIVRVEKSQCIGCSYCIGACPYQVRYLNPVTKVADKCDFCAESRLAKGFPPICVSACPEHALIFGREDSPEIQAWLQQNKYYQYQLPGAGKPHLYRRFGQHLIKKENV
Protein: Glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1) (GAA1 protein homolog) (hGAA1) (O43292)
Organism: Homo sapiens (Human)
Function: Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Multi-pass membrane protein {ECO:0000269|PubMed:11483512}.
Interaction partners:
- GPI-anchor transamidase
- GPI-anchor transamidase component PIGU
- GPI-anchor transamidase component PIGT
- GPI-anchor transamidase component PIGS
- GPI ethanolamine phosphate transferase 3, catalytic subunit
- GPI inositol-deacylase
- GPI ethanolamine phosphate transferase, stabilizing subunit
- GPI alpha-1,6-mannosyltransferase 2
- N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
- GPI alpha-1,2-mannosyltransferase 3
Sequence:
MGLLSDPVRRRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTMVEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFSRKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQAVGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTGMQSSPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASGRPHGSHGLFLRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLYLLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEAGMGLEEPGGAPGPSVPLPPSQGVGLASLVAPLLISQAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHNTHRVVSTQAPDRGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPHGPRTLYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQGVLEHHTYGALLFPLLSLGLYPCWLLFWNVLFWK
Protein: Splicing factor saf5 (O13777)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins smb1, smd1, smd2, smd3, sme1, smf1 and smg1 that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (By similarity). In the cytosol, the Sm proteins smd1, smd2, sme1, smf1 and smg1 are trapped in an inactive 6S pICln-Sm complex by the chaperone saf5 that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of saf5 from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:24298023}. Cytoplasm {ECO:0000269|PubMed:24298023}. Note=Localizes to the nucleus predominantly. {ECO:0000269|PubMed:24298023}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D1
- Protein arginine N-methyltransferase skb1
- Small nuclear ribonucleoprotein Sm D3
- SMN complex subunit smn1
- Small nuclear ribonucleoprotein Sm D2
- V-type ATPase assembly factor pkr1
- Small nuclear ribonucleoprotein E
- SMN complex subunit yip11/gem2
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein F
Sequence:
MITKIDSLPKDLIRKVENGEKLLPNQEIVYFEEKTVPYKIRSDEESFPLGKLITLLVTSQSFILFDEEQNSGWKIPYETITLHAKQSKDKPYVYVQLEGEAIRPLLDHILKFERSSGTLHEAPSTEDENEFTDDFLELTLYVTDVDSCYQALCTCQSLHPDTFSSDNDVENASMGNPMSLFFDPNHQWVTAENVDTSACDNRFDSPESPVLKWHRTE
Protein: Protein KRI1 homolog (Q8N9T8)
Organism: Homo sapiens (Human)
Interaction partners:
- KRR1 small subunit processome component homolog
- Nucleolar protein 14
- Nucleolar complex protein 2 homolog
- U3 small nucleolar ribonucleoprotein protein MPP10
- Ribosome biogenesis protein BMS1 homolog
- ESF1 homolog
- rRNA-processing protein UTP23 homolog
- CCAAT/enhancer-binding protein zeta
- Something about silencing protein 10
- Ribonucleases P/MRP protein subunit POP1
Sequence:
MPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESFRAFVEDSEDEDGAGEGGSSLLQKRAKTRQEKAQEEADYIEWLKGQKEIRNPDSLKELTHLKEYWNDPELDEGERFLRDYILNKRYEEEEEEEEDEEEMEEEEGVHGPPVQLAVDDSSDEGELFLKKQEDFEQKYNFRFEEPDSASVKTYPRSIASSVRRKDERRKEKREETRERKKREKAKKQEELKQLKNLKRKEILAKLEKLRKVTGNEMLGLEEGDLEDDFDPAQHDQLMQKCFGDEYYGAVEEEKPQFEEEEGLEDDWNWDTWDGPEQEGDWSQQELHCEDPNFNMDADYDPSQPRKKKREAPLTGKKKRKSPFAAAVGQEKPVFEPGDKTFEEYLDEYYRLDYEDIIDDLPCRFKYRTVVPCDFGLSTEEILAADDKELNRWCSLKKTCMYRSEQEELRDKRAYSQKAQNSWKKRQVFKSLCREEAETPAEATGKPQRDEAGPQRQLPALDGSLMGPESPPAQEEEAPVSPHKKPAPQKRRRAKKARLLGPTVMLGGCEFSRQRLQAFGLNPKRLHFRQLGRQRRKQQGPKNSS
Protein: ABC transporter G family member 6 (ABC transporter ABCG.6) (AtABCG6) (White-brown complex homolog protein 6) (AtWBC6) (Q9FNB5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Glycerol-3-phosphate acyltransferase 5
- Cytochrome P450 86B1
- Probable fatty acyl-CoA reductase 4
- Omega-hydroxypalmitate O-feruloyl transferase
- Cytochrome P450 86A1
- Transcription factor MYB41
- Glycerol-3-phosphate acyltransferase 7
- Major facilitator superfamily protein
- Probable fatty acyl-CoA reductase 5
Sequence:
MSRVVAADDNMALPFFSPEFGNVSGASSSPTTFAQLLQNVDDSTRRSHHQHHVDVDLASPDQSVPFVLSFTDLTYSVKVRRKFTWRRSVSSDPGAPSEGIFSSKTKTLLNGITGEARDGEILAVLGASGSGKSTLIDALANRIAKGSLKGNVTLNGEVLNSKMQKAISAYVMQDDLLFPMLTVEETLMFAAEFRLPRSLSKSKKSLRVQALIDQLGLRNAANTVIGDEGHRGISGGERRRVSIGIDIIHDPILLFLDEPTSGLDSTSALSVIKVLKRIAQSGSMVIMTLHQPSYRLLRLLDRLLFLSRGQTVFSGSPAMLPRFFAEFGHPIPEHENRTEFALDLIRELEGSAGGTRSLVEFNKGFRQRKAEPRSQTGLSLKEAISASISKGKLVSGATTTTHSSGSSPVSTIPTFANPFWVELAVLAKRSMTNSRRQPELFGIRLGAVLVTGFILATMFWQLDNSPKGVQERLGCFAFAMSTTFYTCADALPVFLQERFIFMRETAYNAYRRSSYVLSHSLVALPSLIILSLAFAAITFWGVGLDGGLMGFLFYFLVILASFWAGSSFVTFLSGVVPHVMLGYTIVVAILAYFLLFSGFFINRDRIPGYWIWFHYISLVKYPYEAVLLNEFGDPTKCFVRGVQIFDNTPLVAVPQGMKVRLLATMSKSLGMRITSSTCLTTGYDILQQQGVTDLTKWNCLWVTVAWGFFFRILFYFSLLLGSKNKRR
Protein: Pico, isoform B (Pico, isoform D) (Q8IQW0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MANLEDSQESELDQILGELSLLEAQISYTEASMLPAMCAPSAGAQIAPPPGVTQLPGSAPTMVSMSASSSRSHSRTNSTISADVSSCSSSGISENGHGLGLVLGGPGSAGMMVQPPPPGGMTMGITLGVVTPREPRTESPDNDSAFSDTVSLLSSESSASSNTSLQQQQQQQQQQHHQHQQHHQHQQQQQKPQLAGAEKLHHHGVHGQHGGQQSGANSITKADKIQLALHKLESAPIRRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELLVDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDEQTRQMLLDEFFDSHNQLQMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACLNLFHGHNVYTGLGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLCLSRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAISSMSNSTSGRTSRASSSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKPNLPLTTMTRQLKEVGEITICESAGGDASSPERSGTLTRRHSRRKSQESNGSGTLKRRPIAVPVATVVKQTEPMGSASSTSSSSNSTPTPTPSICAKPPPGDSASLMCSSTLSLDSLPPPPPPPALDGSEDQDVYGSQLSLASLPPPPPPEDVLAMNYAEPSSPSTPTPMSTPMIMPNSNGSLPPAVPAKPMKPAVKQAAGGLKAAPPYKAPPDYVGPALLPGPPLPPPPPAQKKVSFADSPVLLRRKMCSPEPVLPQRSPSTTLSCHSSSSAGSAYQTYAPGPMLPPRADVARLSSLSNGSSSEVTSPKRLQESASNPPRDFLKDLQRVMRKKWQVAQKCKAEPATTPHEVLGFRDFSNEDLLAAHNLNSGANSSHYYRETANVSHWVRKHYEYAHNALYENVHAQSAAAAGVPGSGEATTPPLPPPPGNSVAAKKRPPPPPPKRSDKTHLTNRV
Protein: Phospholipid-transporting ATPase accessory subunit LEM3 (Alkylphosphocholine resistance protein LEM3) (Brefeldin-A sensitivity protein 3) (Ro-sensitive 3) (P42838)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the asymmetrical organization of phosphatidylethanolamine in the plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12133835, ECO:0000305|PubMed:22791719}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Phospholipid-transporting ATPase DNF2
- Phospholipid-transporting ATPase DNF1
- Phospholipid-transporting ATPase DRS2
- Probable phospholipid-transporting ATPase DNF3
- Phospholipid-transporting ATPase accessory subunit CDC50
- Phospholipid-transporting ATPase NEO1
- Flippase kinase 1
- CDP-diacylglycerol--serine O-phosphatidyltransferase
Sequence:
MVNFDLGQVGEVFRRKDKGAIVSGDNPEEEEDVDASEFEEDEVKPVRTKNRRPKEDAFTQQRLAAINPVLTPRTVLPLYLLIAVVFVIVGGCILAQNSKVDEVTIYYQDCMTNATSSWSDIPSEHWQFVFHKYKTYNTAPQWRFVDDESDDFTKQRGTCQIRFTTPSDMKNNVYLNYVLEKFAANHRRYVLSFSEDQIRGEDASYETVHDATGINCKPLSKNADGKIYYPCGLIANSMFNDTFPLQLTNVGDTSNNYSLTNKGINWESDKKRYKKTKYNYTQIAPPPYWEKMYPDGYNETNIPDIQDWEEFQNWMRPGAFDKITKLIRINKNDTLPAGEYQLDIGLHWPVLEFNGKKGIYLTHGSHLGGRNPFLGIVYLIGGCICAAMALILLTFWLFGGRKIADASSLSWNMK
Protein: TSC complex subunit 2 (A0A2R8YGD6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNSPPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV