wanglab/gogpt-training-data huggingface dataset:
Protein: TITAN-like protein (F4JRR5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Key regulator for endosperm and embryo nuclear divisions.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:22991160}.
Interaction partners:
Sequence:
MKKPSKKSEIEFCTVCRFHHDQGSRHKYFPRHKSSLSSLLDRFRSKIADVRFFLKNPSVLRPQEQSQNRVWCVFCDEDIVELGSSFACSKAINHFASSDHLKNIKQFLSKNGPAMDCIDEFRISEADVAKWEKKCQSFGNEDASFEGSCGQLSGTSNDIHTKLAFETMDRIKKVPAHHINSYKSNDVMPLQYNTNEYQISLSEIPGVIHNGSYLNMDDSQFPLCDESGNGFGEHSIPCRSKDYSGNGNYCTQENYQVSQDKKQIDGSYNPPGVVGMTSISSSHSTDAGGNVHSGAPPPWLDANDGDFSSVQLNQSDVARFQAKVPGKNRKLNPNRVGAAWAERRKIEIEMEKSGHVTKSNIDPDWLPNFGRVWQSGTRKESRKEFEKEKRKLVKTESISTESEPVKIQPYISKRARRESGE
Protein: Myrosinase-binding protein 2 (Jacalin-related lectin 6) (Myrosinase-binding protein-like At1g52030) (MBP) (Q9SAV1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Expressed protein
- Glucosidase 2 subunit beta
- Shaggy-related protein kinase eta
Sequence:
MSEKVGAMGGNKGGAFDDGVFDGVKKVIVGKDFNNVTYIKVEYEKDGKFEIREHGTNRGQLKEFSVDYPNEYITAVGGSYDTVFGYGSALIKSLLFKTSYGRTSPILGHTTLLGNPAGKEFMLESKYGGKLLGFHGRSGEALDAIGPHFFAVNSSLKHFKPQGGNGGSAWDDGAFDGVRKVLVGRNGKFVSYVRFEYAKGERMVPHAHGKRQEAPQEFVVDYPNEHITSVEGTIDGYLSSLKFTTSKGRTSPVFGNVVGSKFVFEETSFKLVGFCGRSGEAIDALGAHFAPLPAPTPAPAPAPAPAPAPAPSPAPASAPVPAPAPTPAPAPAPPNKVEALGGNGGTIFDDGAFDHVRKVYIGQGDSGVAYVKFEYRKDGKRETREHGKMTVLGTEEFEVESDDYITSIEVSVDNVFGFKSEIVTSLVFKTFKGITSQPFGMETEKKLELKDGKGGKLVGFHGKASDVLYALGAYFAPTTNSTTPSTPSTSKKLQARGGNGGASWDDGVFDGVRKILVGQGNDGVAFVTFEYNKGSQAILGDRHGKQTLLGTETFELDYPSEYITSVEGYYDKIFGVEAEVVTSLTFKTNKRTSQPFGMTAGEHFELNEDGYKIVGFHGKAGDLVHQIGVHAVPIFTNYRCVF
Protein: RNA transcription, translation and transport factor protein (A0A8I6AA36)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MFRRKLTALDYHNPTGFNCKEFRNFIVWLEDQKIRHYKIEDRGNLRNIHSSDWPKFFEKYLRDVNCPFKIQDRQEAIDWLLGLAVRLEYGDNAEKYKDSVPDNRKNADNAAKNSEPLINLDVNNPDFKAGVMALANLLQIQRHDDYLVMLKAIRILVQERLTQDAVAKANQMKEKPYIQMHCSCLVTDAVLNEAAQILRLLHIEELRELQTKINEAIVAVQAIIADPKTDHRLGKVGR
Protein: Vesicle transport protein USE1 (USE1-like protein) (F1LQ22)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004163}.
Interaction partners:
- Syntaxin-5
- Syntaxin-18
- Vesicle-trafficking protein SEC22b
- Golgi SNAP receptor complex member 2
- BET1 homolog
- Alpha-soluble NSF attachment protein
- Synaptobrevin homolog YKT6
- Syntaxin-7
- Syntaxin-8
- Vesicle-associated membrane protein 7
Sequence:
MAQAEGACHRPLATSRLELNLVRLLCRCESMAAEKREPDEWRLEKYVGALEDMLQALKVQASKPASEVISEYSRKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTAKERVPATKTVHLQSRARYTSEMRSELLGTLEADMRKRVVKGPRPADEKQSASELDLVLQRHQGLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKLESERLEQHAQKSVNWLLWAMLIVVCFVFISMILFIRIMPRLK
Protein: Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] (P80303)
Organism: Homo sapiens (Human)
Function: Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity).
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:11749975}. Membrane {ECO:0000269|PubMed:11749975}; Peripheral membrane protein {ECO:0000269|PubMed:11749975}. Cytoplasm {ECO:0000269|PubMed:11749975}. Secreted {ECO:0000269|PubMed:11749975}. Endoplasmic reticulum {ECO:0000250}. Nucleus envelope {ECO:0000250}. Note=Golgi retention is mediated by its N-terminal region.; SUBCELLULAR LOCATION: [Nesfatin-1]: Secreted.
Interaction partners:
- Endoplasmic reticulum aminopeptidase 1
- Leptin
- Pro-opiomelanocortin
- Appetite-regulating hormone
Sequence:
MRWRTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFEPHI
Protein: Type VI secretion system spike protein VgrG1c (Q9I0F3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the Tse5/RhsP1 toxin to target cells where it exerts its toxicity.
Subcellular location: Secreted {ECO:0000269|PubMed:21325275}.
Interaction partners:
- Toxin protein Tse5
- Type VI secretion system component TssA1
- DNase toxin Tse7
- Protein hcp1
- AAA+ ATPase ClpV1
- OmpA-like domain-containing protein
- Type VI secretion system sheath protein TssB1
- DUF6484 domain-containing protein
- NAD
- Type VI secretion system accessory component TagJ
Sequence:
MAIGQPFATALGCTIIWRAAGALFGPPAAGDYQGRFPMLFSQHTRLVHVDSPLGPEVLQLQRLEGREELGRLFSHELELVSSNPALPLDALLGKPMSLALELPGGSRRYFHGIVARCSQGAGAGQFASYQVTLRPWLWLLTRTSDCRIFQNQKVPDIIKQVFRDLGFSDFEDALSRSYREWEYCVQYRETSFDFVSRLMEQEGIYYWFRHEKKRHILVLSDAYGAHHSPAGYTSVPYYPPSLGHRERDHFFDWHMAREVQPGSLSLNDYDFQRPGTRLEVRSNVGRAHAAADYPLYDYPGEYVQSQDGEHYARTRIEAIQTQYERVRLRGCARGIGAGHLFHLSNYPRLDQNREYLVVGAEYRVVQELYETGNGGGGAQFESELDCIDAGQAFRPLPSTPVPVVRGPQTAVVVGPKGEEIWTDQYGRVKVHFHWDRHDQSNENSSCWMRVSQAWAGKNWGSIQIPRIGQEVIVSFLEGDPDRPIITGRVYNAEQTVPYELPANATQSGTKSRSSKGGTPANFNEIRMEDKKGAEQLFIHAERNQDIEVENDESHWVGHDRTKTIDHDETVHVKHDRTETVDNNETITVHANRSKTVDRNETVRIGMNKTETILMASLQNVGMGRMENVGLGYSLNVGMMMNTVVGLNQSTQVMKKKTLSVGDSYEVSVGGSDDGSKITLDGQSITLGSQRIELTADREILLRCGQSTIRLTPGEIEILSPNVDINC
Protein: Calmodulin-binding domain-containing protein (V6CLK4)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- BTB domain-containing protein
- Calmodulin-binding domain-containing protein
- Potassium channel domain-containing protein
- G-protein coupled receptors family 1 profile domain-containing protein
- Potassium channel domain-containing protein
Sequence:
MKLEEAVNAAQIQRNESVTSSSAGDVNEIPKTNGGPGHPIVRRKSGMMGKKFPSLQVSHYPVLLLSNSSADNSTNPHPSVTWKTSQQTDTEPTRPEILEESLPKVRKSSSGLKQSSVSARNSLDFRERPRFVRTSTTTSTLSPTSEKPPMPLGQSCSSSGRLHASPKISFSSVVQQTMKWNELGGMGSGRCLSSASPISAAERQQLWGSSMHHSFDDRPSASSEDLFASCNDIDNAYRQQRKRRAGISGAATGGSHQRDGPFACAGGNGYSSAGFSNGRGFPPLGGRSPQSSFDSNQDVAQISMNWMRMNGLGPSLRPFLNSGNHTPKKTVIHNSQSTNHISRIGSLRRMHAADASIDGKLSLSGTQGETASRKSVSIAYSNDLEAGGKGNGAIGDDSTVPLMDEKDDNSGGRLIRREILHEKRRHVSDRALAFAIMGIILMIIENELRTAYVIRPGSSLSHLLKFFIIFTTTALLSFVGYFHVIEIQLFMNANAADDWMVALSFRRTCQIGLELLICMLCPLPIEFIAPFMNDRFHDKTLYAVNVFLSIMMFFRLYWLCRVMLLHSRVFTDASSRSIAGLNRVNFNARFILKTLMTICPGTMLMIFTAFLWIIAGWILRLCEREYMTPDKYNDINYVNSIWLVAITFLSVGYGDIVPKTNCGRSMAIVTGILGTCASSMVVAVIARKLELTRAEKHVHNFMQDTQLTKQLKHSAANVLRETWFIFKFRKLVEKPDFGKIRKHQRKFLLAIYEMRRVRRDQRKLAENLVSLGDVAKTSSNTYELVHDVHSTQEGLSLRITAIEHQLSDISRELSSLAELLRGSNEQRKKSVVIGGESAPPTPQQILKRKIGELRV
Protein: Plastidial pyruvate kinase 3, chloroplastic (PKp3) (EC 2.7.1.40) (Pyruvate kinase I) (Pyruvate kinase isozyme B2, chloroplastic) (PKP-BETA2) (Plastidic pyruvate kinase beta subunit 2) (Q93Z53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for plastidial pyruvate kinase activity.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:17557808, ECO:0000269|PubMed:18431481}.
Interaction partners:
- L-lactate dehydrogenase
- Cytosolic enolase 3
- Bifunctional enolase 2/transcriptional activator
- Enolase 1, chloroplastic
- Glucose-6-phosphate isomerase, cytosolic
- D-lactate dehydrogenase [cytochrome], mitochondrial
- NADP-dependent glyceraldehyde-3-phosphate dehydrogenase])
- Inosine triphosphate pyrophosphatase
- Malate dehydrogenase 3, cytoplasmic
- Malate dehydrogenase 2, peroxisomal
Sequence:
MAAYGQISSGMTVDPQVLSSSRNIGVSLSPLRRTLIGAGVRSTSISLRQCSLSVRSIKISEDSRKPKAYAENGAFDVGVLDSSSYRLADSRTSSNDSRRKTKIVCTIGPSSSSREMIWKLAEAGMNVARLNMSHGDHASHQITIDLVKEYNSLFVDKAIAIMLDTKGPEVRSGDVPQPIFLEEGQEFNFTIKRGVSLKDTVSVNYDDFVNDVEVGDILLVDGGMMSLAVKSKTSDLVKCVVIDGGELQSRRHLNVRGKSATLPSITDKDWEDIKFGVDNQVDFYAVSFVKDAKVVHELKNYLKTCSADISVIVKIESADSIKNLPSIISACDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSIHKPVIVATNMLESMINHPTPTRAEVSDIAIAVREGADAIMLSGETAHGKFPLKAVNVMHTVALRTEASLPVRTSASRTTAYKGHMGQMFAFHASIMANTLSSPLIVFTRTGSMAVLLSHYRPSATIFAFTNQRRIMQRLALYQGVMPIYMEFSDDAEDTYARSLKLLQDENMLKEGQHVTLVQSGSQPIWREESTHLIQVRKIKIGG
Protein: MHC class I protein (RT1 class I, A3) (RT1 class Ia, A3n) (Q9JHM2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAPRTLLLLLAAALAPTQTQAGSHSLRYFDIAVSRPGLGEPRFIIVGYVDDREVMRFDSDAENPRMKPRARWMEREGPEYWERQTRKVKEKEQIFRDNLRTLLRYYNQSEGGSHTVQRLSGCDVGSDGSLLRGYNQHAYDGRDYIALNEDLKTWTAADTAAQITKNKWERDGEAERRRAYLEGECVEWLRSYLAPRKETLLRSDPPKAHVTLHPRPEGDVTLRCWALGFYPADITLTWQLNGEDLTQDMEFVETRPAGDGTFQKWASVVVPSGEEQNYTCLVEHEGLPKPLTQRWEPSPSTNTNMGIDVTSVVLGAVAVFVVLAIIGAVVCVVRRRRRRRNTGGKGDYTPARGRDSSQSSDVSLPDCKA
Protein: Sperm protamine P1 (Cysteine-rich protamine) (P04553)
Organism: Homo sapiens (Human)
Function: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Protamine-2
- Spermatid nuclear transition protein 1
- Nuclear transition protein 2
- Nuclear protein 1
- Lysine-specific demethylase 3A demethylase 3A)
- Kelch-like protein 10
- Transcription factor AP-4
Sequence:
MARYRCCRSQSRSRYYRQRQRSRRRRRRSCQTRRRAMRCCRPRYRPRCRRH
Protein: Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3) (P30048)
Organism: Homo sapiens (Human)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:33889951}. Cytoplasm {ECO:0000305|PubMed:12492477}. Early endosome {ECO:0000269|PubMed:15750338}. Note=Localizes to early endosomes in a RPS6KC1-dependent manner. {ECO:0000269|PubMed:15750338}.
Interaction partners:
- Peroxiredoxin-5, mitochondrial
- Thioredoxin, mitochondrial
- Fanconi anemia group G protein
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- Thioredoxin reductase 2, mitochondrial
- Thioredoxin
- Non-selective voltage-gated ion channel VDAC1
- Thioredoxin reductase 1, cytoplasmic
- Superoxide dismutase
- Superoxide dismutase, mitochondrial
Sequence:
MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ
Protein: Inner tegument protein (Q6SW85)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex.
Subcellular location: Virion tegument {ECO:0000255|HAMAP-Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
Interaction partners:
Sequence:
MMARRTVDFKKLIEQLRARATDKAEALNTVSQLEIGAVDAQDVTASAVRAFVGALPSSGYHFGFVRQNVVFYLLSHATVQTARDPLYAAEQLHEQLDRFLRHQHDGGGDEDRLPFYHNGATLTAFQKLLQTLREIQTVIAEQSGGTAAAADLIASNNASTERRGKKGGSSSGGQQPLVRRVITQLETAATEARPYVNCRAVAELLDLTYQRLIYWACTLMPYVLFRRDTDTELDTVLLMHFFYTHYRSVNGDLAVEFQNYVKNSVRHMSSFVSSDIDGDQKPGAEHMRDVSYKLFVGNLQARDASGLMFPIISTRISTVNLYLSPERMFFHPGLISRLLSEEVSPRANLDAYARVCDRVLEDHLHTPRRVQRLLDLTQMVMRLVELGFNHDTCAAYAQMALIQPASQKSSLFVSEIREKLIQIIYNFYTFFMCLYVYSPTFLFDHRRRLILEQHRSTLIGSKEELQHVWSNVTLNVNTHFAVQYTEEDFEAHTKGATEAEREYLYRDLHSKWGVHLFTLRPSRGAAGAASPLPPLDGVTRSDILRECALVNLNEGRVNYASLLAFSHHPEFPSIFAQLVVVTEFSEIFGIPQGLFQAVGSPRLFALIQLCRVLLPEQVTLYQNLVSIYNLTTFVKHIDAAVFKTVRDCVFDIATTLEHLSGVPVTPNVDLLAELMARSVAHNLYTTVNPLIEDVMRSSAGSLRNYLRHTRLCFGLARGRARLSEDGVTVYVEVQGQYGLRVPTTRFVEQLRELVRRDRLLAENLRGLNERLLSVRVRVRQISSDTEEVSRHAKGHRTVAQMSKALKKTASKIKMLETRVTLALEQAQRSNGAVVTAVQRALAVFDVLSRENLERRGAQLCLTEATSLLHRHRALAPMTWPAGTGVAAAAEADGALREFLEAPWESAPQPPRLRMTPDTDHEESTAGATSVPEVLGARYEPAHLAASDLLNWYIVPVSQAQQDILSSIDPPAGSTSVSLPPASP
Protein: Non-structural maintenance of chromosomes element 4 (Q9VKV4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365071}.
Interaction partners:
- MAGE
- SD25546p
- Non-structural maintenance of chromosomes element 1 homolog
- Structural maintenance of chromosomes protein 5
- E3 SUMO-protein ligase NSE2
- E3 SUMO-protein ligase NSE2
- E3 SUMO-protein ligase NSE2
- E3 SUMO-protein ligase NSE2
- Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein
Sequence:
MDSSESQSQMDDQDARILRLQNLIEKNIEIEQQIENNTIGESITAIEEIIQTANDISKGHEDRRTNSTELVLDTELLRRNFEVVGKAIQHNTNVTDRMVATAINDLVFKESEEDWDALCSLAIQFGRPLFTNDSMLPFIDVTPKVVVQKQRAPRKTKSQVDEKRPEKSDQLERKDEGAASVTHMLKQIRQIYRDGNQEPIPYFKLICNPNNFMDTVQNALQLSFLVKENYISIENGEDGLPLVRVVNSKSVEGNAPSQAICSIDVTFCEKMVKHYNLHEPMLKRLPVSEK
Protein: Possible transcriptional activator protein (O06807)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved protein
- Possible transcriptional regulatory protein
- Transcriptional regulatory protein
- Probable methanol dehydrogenase transcriptional regulatory protein MoxR2
- Transcriptional regulatory protein MoaR1
- Transcriptional regulatory protein EmbR
- HTH-type transcriptional regulator Cmr
- Uncharacterized protein Rv0894
- Probable quinone reductase Qor
- Probable transcriptional regulatory protein
Sequence:
MALRETSPRIHELIREAARIALNPTQEWLDEFDRAILAANPSIAADPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALDIYRIGQNVAWRRWTDIAFGLTSDPDELHELLDVPFRTANEFVDTTLAGITTEMQLERDKLTRDVPAERRKIVQLLIDGAPISREHAEARLGYPLDRSHTAAVIWGDQAQGDHSHLDRVADAFGHAGGCPHPLVVVAGAATRWVWVKDAPGFDIDLIHEVLHDIPDARIAIGATAPGIEGFRRSHRDALTTARMIIRLESPHRVAFFTDVEMVALLTENAEGADDFIQRTLGNLESASPALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALEAQQWREKPTSDPPAKKESNGTKMR
Protein: Protrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27) (Q5T4F4)
Organism: Homo sapiens (Human)
Function: Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner.
Subcellular location: Recycling endosome membrane {ECO:0000250|UniProtKB:Q6P7B7}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24668814}; Multi-pass membrane protein {ECO:0000269|PubMed:23969831}. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:Q3TXX3}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes at both dendrites and axons (By similarity). Localizes to endoplasmic reticulum tubular network. {ECO:0000250|UniProtKB:Q3TXX3, ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24668814}.
Interaction partners:
- Ras-related protein Rab-11A
- Spastin
- Receptor expression-enhancing protein 1
- Vesicle-associated membrane protein-associated protein A
- StAR-related lipid transfer protein 3
- FYVE and coiled-coil domain-containing protein 1
- WASH complex subunit 5
- PDZ domain-containing protein 8
- Vesicle-associated membrane protein-associated protein B/C
- Delta-1-pyrroline-5-carboxylate synthase
Sequence:
MQTSEREGSGPELSPSVMPEAPLESPPFPTKSPAFDLFNLVLSYKRLEIYLEPLKDAGDGVRYLLRWQMPLCSLLTCLGLNVLFLTLNEGAWYSVGALMISVPALLGYLQEVCRARLPDSELMRRKYHSVRQEDLQRGRLSRPEAVAEVKSFLIQLEAFLSRLCCTCEAAYRVLHWENPVVSSQFYGALLGTVCMLYLLPLCWVLTLLNSTLFLGNVEFFRVVSEYRASLQQRMNPKQEEHAFESPPPPDVGGKDGLMDSTPALTPTEDLTPGSVEEAEEAEPDEEFKDAIEETHLVVLEDDEGAPCPAEDELALQDNGFLSKNEVLRSKVSRLTERLRKRYPTNNFGNCTGCSATFSVLKKRRSCSNCGNSFCSRCCSFKVPKSSMGATAPEAQRETVFVCASCNQTLSK
Protein: Growth hormone (H6UQ66)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MAPGSWFSPLLIAVVTLGLPHETVATFPTMPLSNMFANAVLRAQHLHLLAAETYKEFERTYIPEDQRYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMEVVRFSLVFIQSWLTPVQYLSKVFTNKLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRHGDALLNNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI
Protein: N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP) (P17560)
Organism: Sus scrofa (Pig)
Function: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity).
Interaction partners:
- Leucine rich repeat containing 17.
Sequence:
MEKERETLQAWKERVGQELDRVMAFWLEHSHDREHGGFFTCLGRDGRVYDDLKYVWLQGRQVWMYCRLYRKLERFHRPELLDAAKAGGEFLLRHARVAPPEKKCAFVLTRDGRPVKVQRSIFSECFYTMAMNELWRVTAEARYQSEAVDMMDQIVHWVREDPSGLGRPQLPGAVASESMAVPMMLLCLVEQLGEEDEELAGRYAQLGHWCARRILQHVQRDGQAVLENVSEDGEELSGCLGRHQNPGHALEAGWFLLRHSSRSGDAKLRAHVIDTFLLLPFRSGWDADHGGLFYFQDADGLCPTQLEWAMKLWWPHSEAMIAFLMGYSESGDPALLRLFYQVAEYTFRQFRDPEYGEWFGYLNREGKVALTIKGGPFKGCFHVPRCLAMCEEMLSALLSRLA
Protein: N5-carboxyaminoimidazole ribonucleotide synthase (N5-CAIR synthase) (EC 6.3.4.18) (5-(carboxyamino)imidazole ribonucleotide synthetase) (P09029)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Interaction partners:
- Phosphoribosylformylglycinamidine synthase
- N5-carboxyaminoimidazole ribonucleotide mutase
- Phosphoribosylformylglycinamidine cyclo-ligase
- Amidophosphoribosyltransferase
- Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Bifunctional purine biosynthesis protein PurH
- Phosphoribosylamine--glycine ligase
- Phosphoribosylglycinamide formyltransferase
- Adenylosuccinate lyase
- Formate-dependent phosphoribosylglycinamide formyltransferase
Sequence:
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVKRRTGGYDGRGQWRLRANETEQLPAECYGECIVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANAQQQAQAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWTQNGASISQFELHLRAITDLPLPQPVVNNPSVMINLIGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWAQSKFG
Protein: Xylosyltransferase 2 (EC 2.4.2.26) (Peptide O-xylosyltransferase 2) (Xylosyltransferase II) (Q9EPL0)
Organism: Mus musculus (Mouse)
Function: Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9H1B5}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9H1B5}. Secreted {ECO:0000250|UniProtKB:Q9H1B5}.
Interaction partners:
- Beta-1,4-galactosyltransferase 7
- Xylosyltransferase 1
- Beta-1,3-galactosyltransferase 6
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
- Exostosin-like 3
- Syndecan-1
- Exostosin-like 2
- Glycosaminoglycan xylosylkinase
Sequence:
MVASARVQKLVRRYKLAIATALAILLLQGLVVWSFSGLEEDEPGEKGRQRKPRPLDPGEGSKDTDSSAGRRGSAGRRHGRWRGRAESPGVPVAKVVRAVTSRQRASRRVPPAPPPEAPGRQNLSGAAAGEALIGAPGFPQHGDTGSVEGAPQPTDNTFTPKCEIVGKDALSALARASTKQCQQEIANVVCLHQAGNLMPKSVPRHCQLAGKMSPGVQWEEIRAQQPVGGPPVRIAYMLVVHGRAIRQLKRLLKAVYHEQHFFYIHVDKRSNYLYREVVELAQHYENVRVTPWRMVTIWGGASLLRMYLRSMKDLLEIPGWTWDFFINLSATDYPTRTNEELVAFLSKNRDKNFLKSHGRDNSRFIKKQGLDRLFHECDSHMWRLGERQIPAGIVVDGGSDWFVLTRSFVEYVVYTDDPLVAQLRQFYTYTLLPAESFFHTVLENSPACASLVDNNLRVTNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFLRLQQVSRPTFFARKFESTVNQEVLEILDFHLYGSYPPSTPALKAYWENIYDVADGPGGLSDVLLTAYTAFARLSLRHAATAVSPLATAVCRFEPRGLPSSVHLYFYDDHFQGYLVTQAVQPSAQGPAETLEMWLMPQRSLKLLGHSDQASRLQSLEVGTEWDPKERLFRNFGGLLGPLDEPVAMQRWARGPNLTATVVWIDPTYVVATSYDITVDADTEVTQYKPPLSLPLRPGAWTVRLLQFWEPLGETRFLVLPLTFNRKLPLRKDDASWLHAGPPHNEYMEQSFQGLSGILNLPQAEALEEAARRHTELTGSALEAWTDGELSNFWSVAGLCAIGPSACPSLELCRLTSWSSLSPDPKSELGPVKADGRLR
Protein: Homeodomain-like transcriptional regulator (Myb family transcription factor) (Similarity to I-box binding factor) (Q9LT00)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNLGQEISVGSSWSKDDDIAFEKALAIYNDKTEIRWKKIATVVPGKTLEQVIEHYNILARDVMLIESGCVRLPDYDDFLEEPNHNAFGKERSILEGGNDRKYESKHKGKSKLKQKRRRGVPWKPFEHRQFLHGLKKYGKGDWRSISRHCVVTRTSTQVASHAQKYFAHINSEDKKRKRPSIHDITIAENKSISTKQRPITWQKINNNGATASNTQANQTTLQPSLDIPIYGTHNNIWNAQATQVISQPSQNHPTYDAPIIWNTQVASQPSANIPMYGTSTISQPMVGPMLSPFGTNLNHLAPSHMTSGVQHDSVPYYSGPSAPINMDSIPYNIDLYN