Protein: Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-alpha); Nsp1-beta papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-beta); Nsp2 cysteine proteinase (EC 3.4.19.12) (EC 3.4.22.-) (CP2) (CP); Non-structural protein 3 (Nsp3); Serine protease nsp4 (3CLSP) (EC 3.4.21.-) (3C-like serine proteinase) (Nsp4); Non-structural protein 5-6-7 (Nsp5-6-7); Non-structural protein 5 (Nsp5); Non-structural protein 6 (Nsp6); Non-structural protein 7-alpha (Nsp7-alpha); Non-structural protein 7-beta (Nsp7-beta); Non-structural protein 8 (Nsp8); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (Nsp9); Helicase nsp10 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Nsp10); Uridylate-specific endoribonuclease nsp11 (EC 4.6.1.-) (Non-structural protein 11) (Nsp11); Non-structural protein 12 (Nsp12)] (A6YQT5)
Organism: Porcine reproductive and respiratory syndrome virus (PRRSV)
Subcellular location: [Nsp1]: Host nucleus {ECO:0000250|UniProtKB:Q04561}. Host cytoplasm {ECO:0000250|UniProtKB:Q04561}.; SUBCELLULAR LOCATION: [Nsp1-alpha papain-like cysteine proteinase]: Host nucleus {ECO:0000250|UniProtKB:Q04561}. Host cytoplasm {ECO:0000250|UniProtKB:Q04561}.; SUBCELLULAR LOCATION: [Nsp1-beta papain-like cysteine proteinase]: Host nucleus {ECO:0000269|PubMed:35858300}. Host cytoplasm {ECO:0000269|PubMed:35858300}. Note=Accumulates mainly in the host cytoplasm in early infection and then mostly in the host nucleus. {ECO:0000269|PubMed:35858300}.; SUBCELLULAR LOCATION: [Nsp2 cysteine proteinase]: Host cytoplasm {ECO:0000250|UniProtKB:Q04561}. Host membrane {ECO:0000250|UniProtKB:Q04561}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q04561}.; SUBCELLULAR LOCATION: [Non-structural protein 3]: Host membrane {ECO:0000250|UniProtKB:Q04561}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q04561}.; SUBCELLULAR LOCATION: [Non-structural protein 5-6-7]: Host endoplasmic reticulum {ECO:0000250|UniProtKB:Q04561}. Host membrane {ECO:0000250|UniProtKB:Q04561}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q04561}.; SUBCELLULAR LOCATION: [Serine protease nsp4]: Host cytoplasm {ECO:0000250|UniProtKB:Q04561}.; SUBCELLULAR LOCATION: [RNA-directed RNA polymerase]: Host cytoplasm {ECO:0000250|UniProtKB:Q04561}. Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q04561}.; SUBCELLULAR LOCATION: [Helicase nsp10]: Host cytoplasm {ECO:0000250|UniProtKB:Q04561}. Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q04561}.; SUBCELLULAR LOCATION: [Uridylate-specific endoribonuclease nsp11]: Host cytoplasm {ECO:0000250|UniProtKB:Q04561}. Host nucleus {ECO:0000250|UniProtKB:Q04561}.; SUBCELLULAR LOCATION: [Non-structural protein 12]: Host cytoplasm {ECO:0000250|UniProtKB:Q04561}.
Interaction partners:
Sequence:
MSGILDRCTCTPNARVFVAEGQVYCTRCLSARSLLPLNLQVPELGVLGLFYRPEEPLRWTLPRAFPTVECSPAGACWLSAIFPIARMTSGNLNFQQRMVRVAAEIYRAGQLTPTVLKTLQVYERGCRWYPIVGPVPGVGVYANSLHVSDKPFPGATHVLTNLPLPQRPKPEDFCPFECAMADVYDIGRGAVMYVAGGKVSWAPRGGNEVKFEPIPKELKLVANRLHTSFPPHHVVDMSRFTFMTPGSGVSMRVEYQHGCLPADTVPEGNCWWRLFDSLPPEVQYKEIRHANQFGYQTKHGVPGKYLQRRLQVNGLRAVTDTHGPIVIQYFSVKESWIRHLKLVEEPSLPGFEDLLRIRVEPNTSPLAGKDEKIFRFGSHKWYGAGKRARKPRSGATTMVAHHASSAHETRQATKHEGAGANKAEHLKRYSPPAEGNCGWHCISAIANRMVNSNFETTLPERVRPSDDWATDEDLVNTIQILRLPAALDRNGACGSAKYVLKLEGEHWTVSVIPGMSPTLLPLECVQGCCEHKGGLVSPDAVEISGFDPACLDRLAKVMHLPSSTIPAALAELSDDSNRPVSPAATTWTVSQFYARHRGGDHHDQVCLGKIISLCQVIEDCCCHQNKTNRATPEEVAAKIDQYLRGATSLEECLAKLERVSPPSAADTSFDWNVVLPGVEAANQTTEQPHVNSCCTLVPPVTQEPLGKDSVPLTAFSLSNCYYPAQGDEVHHRERLNSVLSKLEEVVLEEYGLMSTGLGPRPVLPSGLDELKDQMEEDLLKLANTQATSEMMAWAAEQVDLKAWVKSYPRWTPPPPPPRVQPRRTKSVKSLPEGKPVPAPRRKVRSDCGSPVLMGDNVPNGSEETVGGPLNFPTPSEPMTPMSEPVLVPASRRVPKLMTPLSGSAPVPAPRRTVTTTLTHQDEPLDLSASSQTEYEAFPLAPSQNMGILEAGGQEVEEVLSEISDILNDTNPAPVSSSSSLSSVKITRPKYSAQAIIDSGGPCSGHLQKEKEACLSIMREACDASKLGDPATQEWLSRMWDRVDMLTWRNTSAYQAFRILNGRFEFLPKMILETPPPHPCGFVMLPRTPAPSVSAESDLTIGSVATEDVPRILGKIGDTDELLDRGPSAPSKGEPVCDQPAKDPRMSPRESDESMIAPPADTGGVGSFTDLPSSDGVDVDGGGPLRTVKTKAGRLLDQLSCQVFSLVSHLPIFFSHLFKSDSGYSPGDWGFAAFTLFCLFLCYSYPFFGFAPLLGVFSGSSRRVRMGVFGCWLAFAVGLFKPVSDPVGTACEFDSPECRNVLHSFELLKPWDPVRSLVVGPVGLGLAILGRLLGGARYIWHFLLRLGIVADCILAGAYVLSQGRCKKCWGSCVRTAPNEIAFNVFPFTRATRSSLIDLCDRFCAPKGMDPIFLATGWRGCWTGRSPIEQPSEKPIAFAQLDEKRITARTVVAQPYDPNQAVKCLRVLQAGGAMVAEAVPKVVKVSAIPFRAPFFPAGVKVDPECRIVVDPDTFTTALRSGYSTANLVLGTGDFAQLNGLKIRQISKPSGGGPHLIAALHVACSMALHMLAGVYVTAVGSCGTGTNDPWCTNPFAVPGYGPGSLCTSRLCISQHGLTLPLTALVAGFGLQEIALVVLIFVSIGGMAHRLSCKADMLCILLAIASYVWVPLTWLLCVFPCWLRWFSLHPLTILWLVFFLISVNIPSGILAVVLLVSLWLLGRYTNIAGLVTPYDIHHYTSGPRGVAALATAPDGTYLAAVRRAALTGRTMLFTPSQLGSLLEGAFRTQKPSLNTVNVVGSSMGSGGVFTIDGKIKCVTAAHVLTGNSARVSGVGFNQMLDFDVKGDFAIADCPNWQGVAPKAQFCEDGWTGRAYWLTSSGVEPGVIGNGFAFCFTACGDSGSPVITEAGELVGVHTGSNKQGGGIVTRPSGQFCNVKPIKLSELSEFFAGPKVPLGDVKIGSHIIKDTCEVPSDLCALLAAKPELEGGLSTVQLLCVFFLLWRMMGHAWTPLVAVGFFILNEILPAVLVRSVFSFGMFVLSWLTPWSAQVLMIRLLTAALNRNRWSLGFYSLGAVTSFVADLAVTQGHPLQVVMNLSTYAFLPRMMVVTSPVPVIACGVVHLLAIILYLFKYRCLHNVLVGDGVFSSAFFLRYFAEGKLREGVSQSCGMSHESLTGALAMRLTDEDLDFLTKWTDFKCFVSASNMRNAAGQFIEAAYAKALRIELAQLVQVDKVRGTMAKLEAFADTVAPQLSPGDIVVALGHTPVGSIFDLKVGSTKHTLQAIETRVLAGSKMTVARVVDPTPAPPPVPVPIPLPPKVLENGPNAWGDEDRLSKKKRRRMEAVGIFVMDGKKYQKFWDKNSGDVFYEEVHISTDEWECLRTGDPVDFDPETGIQCGHITIEDKVYNVFTSPSGRRFLVPANPENRRAQWEAAKLSVEQALGMMNVDGELTAKELEKLKRIIDKLQGLTKEQCLNCLLAASGLTRCGRGGLVVTETAVKIVKFHNRTFTLGPVNLKVASEVELKDAVEHNQHPVARPVDGGVVLLRSAVPSLIDVLISGADASPKLLARHGPGNTGIDGTLWDFEAEATKEEVALSAQIIQACDIRRGDAPEIGLPYKLYPVRGNPERVKGVLQNTRFGDIPYKTPSDTGSPVHAAACLTPNATPVTDGRSVLATTMPSGFELYVPTIPASVLDYLDSRPDCPKQLTEHGCEDAALRDLSKYDLSTQGFVLPGVLRLVRKYLFAHVGKCPPVHRPSTYPAKNSMAGINGNRFPTKDIQSVPEIDVLCAQAVRENWQTVTPCTLKKQYCGKKKTRTILGTNNFIALAHRAALSGVTQGFMKKAFNSPIALGKNKFKELQAPVLGRCLEADLASCDRSTPAIVRWFAANLLYELACAEEHLPSYVLNCCHDLLVTQSGAVTKRGGLSSGDPITSVSNTIYSLVIYAQHMVLSYFKSGHPHGLLFLQDQLKFEDMLKVQPLIVYSDDLVLYAESPSMPNYHWWVEHLNLMLGFQTDPKKTTITDSPSFLGCRIINGRQLVPNRDRILAALAYHMKASNVSEYYASAAAILMDSCACLEYDPEWFEELVVGIAQCARKDGYSFPGPPFFLSMWEKLRSNHEGKKSRMCGYCGAPAPYATACGLDVCVYHTHFHQHCPVIIWCGHPAGSGSCSECEPPLGKGTSPLDEVLEQVPYKPPRTVIMHVEQGLTPLDPGRYQTRRGLVSVRRGIRGNEVDLPDGDYASTALLPTCKEINMVAVASNVLRSRFIIGPPGAGKTHWLLQQVQDGDVIYTPTHQTMLDMIRALGTCRFNVPAGTTLQFPAPSRTGPWVRILAGGWCPGKNSFLDEAAYCNHLDVLRLLSKTTLTCLGDFKQLHPVGFDSHCYVFDIMPQTQLKTIWRFGQNICDAIQPDYRDKLMSMVNTTRVTYVEKPVRYGQVLTPYHRDREDGAITIDSSQGATFDVVTLHLPTKDSLNRQRALVAITRARHAIFVYDPHRQLQSMFDLPAKGTPVNLAVHRDEQLIVLDRNNREITVAQALGNGDKFRATDKRVVDSLRAICADLEGSSSPLPKVAHNLGFYFSPDLTQFAKLPVELAPHWPVVTTQNNERWPDRLVASLRPIHKYSRACIGAGYMVGPSVFLGTPGVVSYYLTKFVRGEAQVLPETVFSTGRIEVDCREYLDDREREVAESLPHAFIGDVKGTTVGGCHHVTSKYLPRFLPKESVAVVGVSSPGKAAKAVCTLTDVYLPDLEAYLHPETQSRCWKVMLDFKEVRLMVWKDKTAYFQLEGRHFTWYQLASYASYIRVPVNSTVYLDPCMGPALCNRRVVGSTHWGADLAVTPYDYGAKIILSSAYHGEMPPGYKILACAEFSLDDPVRYKHTWGFESDTAYLYEFTGNGEDWEDYNDAFRARQKGKIYKANATSMRFHFPPGPVIEPTLGLN