wanglab/gogpt-training-data huggingface dataset:
Protein: Lebercilin-like protein (Leber congenital amaurosis 5-like protein) (O95447)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLADLTKTNIDEHFFGVALENNRRSAACKRSPGTGDFSRNSNASNKSVDYSRSQCSCGSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDVLVREKFKRSMQRNGVDDTLGKGTAPYTKGPLRQRRHYSFTEATENLHHGLPASGGPANAGNMRYSHSTGKHLSNREEMELEHSDSGYEPSFGKSSRIKVKDTTFRDKKSSLMEELFGSGYVLKTDQSSPGVAKGSEEPLQSKESHPLPPSQASTSHAFGDSKVTVVNSIKPSSPTEGKRKIII
Protein: C1qc protein (Complement component 1, q subcomponent, C chain) (Q5XJ71)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MPGLPGIPGFPGRDGRQGMKGEKGDLGIPIKPGDTVKKGERGAFGLKGPPGKRGPHGDPGIMGPPGPPGEPGEAGLVDVSGSQLQSAFSVFRHTRIPPDANKVIRFSKVITNPQGHFSTDESKFVCKIPGTYYFVFHASSHDKKLCVILVHDDKNLVSFCDHTQRGSQQVSSGGLSLYLKENEKVWLMTNALNGMYATADRADSVFSGFLIHAH
Protein: Rtg1p (Q5APP3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Rtg3p
Sequence:
MSQFGEFYDTYSVENNQQYDTDLNNSTNTPIVQSKQRNDNIIPSINIKQEDFDSVLSGSLDVKKQLSSSLNTAGVGIGSSYGNGGISKPQSRRNSTYIKSHEGSDNEDEDDQNDKDVGNERKRRDNINDKIQELLTLIPSEFFQSNTDNNTKTGTKVVKENSPEDDAVKNSGTKDGKPNKGQILTKSVEYLQYLQNLIDENNRKEVELIMRLKTLELKAANRPSENIPIRIGYTSAEKALGEIGVGPCSEEYFKNVLIKSASTSKSGRRGSTSG
Protein: PRA1 family protein C (AtPRA1.C) (Q1G3K7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18583532}; Multi-pass membrane protein {ECO:0000269|PubMed:18583532}.
Interaction partners:
- PRA1 family protein B5
- PRA1 family protein H
- PRA1 family protein A3
- PRA1 family protein A2
- PRA1 family protein A1
- PRA1 family protein G1
- PRA1 family protein G2
- PRA1 family protein B6
Sequence:
MIFRTNYIVIFIVSIFISMLWQPVHLSVFVILIVAWLYVYSRDNEPWVIFGSVIDDSTLVLVLLVLTIGIFLLTDVSRGIVIGVLAGLPVVLVHGMCRRNTEMLFVLEDDEEKVAMNTSSSSLSSSS
Protein: Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) (P47955)
Organism: Mus musculus (Mouse)
Function: Plays an important role in the elongation step of protein synthesis.
Interaction partners:
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein P2
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein uS15
Sequence:
MASVSELACIYSALILHDDEVTVTEDKINALIKAAGVSVEPFWPGLFAKALANVNIGSLICNVGAGGPAPAAGAAPAGGAAPSTAAAPAEEKKVEAKKEESEESEDDMGFGLFD
Protein: Tubulin beta-2A chain (Tubulin beta class IIa) (Q13885)
Organism: Homo sapiens (Human)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Tubulin alpha-1A chain
- Tubulin alpha-1B chain
- Tubulin alpha-4A chain
- Tubulin alpha-1C chain
- Tubulin alpha-8 chain
- T-complex protein 1 subunit alpha
- Tubulin alpha chain-like 3
- Tubulin alpha-3E chain
- Tubulin alpha-3C chain
- T-complex protein 1 subunit zeta
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
Protein: Serum response factor a (A8HAM3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Myocardin-related transcription factor Ab
- ETS transcription factor ELK1.
- NK2 homeobox 5.
- Si:dkeyp-69b9.3.
- ETS domain-containing protein Elk-4 isoform 1
- Actin alpha 1, skeletal muscle b.
- Myoblast determination protein 1 homolog
- Myogenin.
- GATA-binding protein 4.
- Serine/threonine-protein kinase Sgk1
Sequence:
MLGGNGTARGAGRSGNGTGLTPLQVGSTSGALGAVNSVINLPDGGRYDDGPSVEAVLSGSDGDSDSGDDEESPVPDRRGVKRERSELEVGGSSGSNAALSAGYGGVSSGVAGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRTDPSTDQRMSATGFEETDLTYQVSEADGLTEPKEMLKPTFTAATLPGGTNTISTTTQSPVSSSPSSSSVAMHTQSSGPSLSGTTCWPVAAGMNAQSISSANGTVLKSSSAGMMQLPSGFTLMPGASLPPGTHTVPLSQLQTHSLAIQCPQTQANSSGSTAVPAHTQPAALFRLPAAVSLTGGAMPQQLQAIQVHPSPQSSDSSPEISQTSSSATASHTATIVTSSVPSSVAGHMMYPGAHVMYATSTPALTDGGLTVLSAFPQPPSAMHVSHTPNQDSGGVPQMFLTGPPGTVQIPVSAVPLHSMLINQQPSGSSSSTLTELRVVNLDNPKGD
Protein: WD repeat-containing protein 35 (Q8BND3)
Organism: Mus musculus (Mouse)
Function: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21473986}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:21473986}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21473986}. Note=Immunofluorescence studies in IMCD3 cells show that Wdr35 accumulates at and around centrosomes and basal bodies of serum-starved cells, with fainter punctate staining along the cilia axoneme.
Interaction partners:
- Intraflagellar transport protein 122 homolog
- WD repeat-containing protein 19
- Intraflagellar transport protein 140 homolog
- Intraflagellar transport protein 43 homolog
- Tetratricopeptide repeat protein 21B
- Intraflagellar transport protein 80 homolog
- Intraflagellar transport protein 172 homolog
- Intraflagellar transport protein 56
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 88 homolog
Sequence:
MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDINIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNSEKYVKYVKSLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKLLGNLQSESMKQAEVIAYFGRFEDAERMYQDMDRRDLAIGLRMKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGEYFADRQKWQNAVQYYVKGRNQERLAECYYMLEDYEGLETLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE
Protein: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (EC 3.2.1.96) (Q86B46)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
Sequence:
MSLRRGLYISPALAAQLEAEPIKDNRQLLEFRVRSRNIDWREYVLPLDTSVRTTPVYLDRQADFVGSTRRQVTEDNRRELLVCHDMMGNYLEDRHFHSSQKYDDYRFVHWSAVDYFCYFSHDYVTIPPCGWLNAAHRHGVPVVGTFIVEATARLDEFLASEESVESTVEALTRLCEHFGFEGWLVNVEVTVPLAKMPRLYRFVRQLTAATESRVPHGRVFWYDSVTDDGQLRWQNELNSRNAKFFRHSHGTLINYAWDEGHLERSAQQVRREQSPRHRVFMGLDVFGRSRKGGFHSWETMELIAKNGFSAGIFAPGWTFETLNRFGYNIKNPRGDDQVNASFLARNEAWWSRIWPTLATHPYTSLPFFTDFCVGSGRAKFERGWRILGEDSPFFNLSRQSLQPSVPLGRNAMHHFDEAYSGGCSLLVTNYERAFRLFVTDFELDRGVLLLRYVFKIDGDAVGTMFDLLVRVTPLRRNDQDLHLFCGDYEGSIVAPQRCYLSPHESDLPSGLFRLHHDSSSLAAGWQMRDYLVKFDGPVRVQDIGVKYQRPSESSTDAKLGFVYVDGLTLEDLKDTWTDIPVYSKHMWNEQRA
Protein: Ets1a protein (Protein C-ets-1) (V-ets erythroblastosis virus E26 oncogene homolog 1a) (Q568B4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MTAAVDIKPLTIIKSEKVDDLECADVPLLTPGSKEMMSQALLATFSGFTREQQRLSIPKDPREWTEGHVREWLTWTVNEFSLKNVDFHKFSMDGASLCALGKERFLDLAPDFVGDILWGHLEMLQKEDPKHFPVSSLSSSFQESRYPSEYFFNYGIEHPQCVPPSEYSEPSFITESYQTLHPISSEDLLSLKYESEYPNVILRDAPLNPLQGDYFSVKQEVVSPDNMCVGRISRGKLGGQDSFESIDSFESCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPSALHAHKPKGTFKDYVRERSDLSKDKPVIPAAALAGYTVDPSSSGSSCWSS
Protein: Uncharacterized protein C11orf71 (Q6IPW1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALNNVSLSSGDQRSRVAYRSSHGDLRPRASALAMVSGDGFLVSRPEAIHLGPRQAVRPSVRAESRRVDGGGRSPREPDGRGRSRQARFSPYPIPAVEPDLLRSVLQQRLIALGGVIAARISV
Protein: Leucine-responsive regulatory protein (O05140)
Organism: Proteus mirabilis
Interaction partners:
Sequence:
MIDNKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFISGYTALLNPHYLDASLLVFVEITLNRGAPDVFEQFNMAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
Protein: Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein) (Q9NZD8)
Organism: Homo sapiens (Human)
Function: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:11113139}. Membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Endosome membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golgi network.
Interaction partners:
- Aldehyde dehydrogenase family 16 member A1
- Spatacsin
- Mitochondrial inner membrane m-AAA protease component paraplegin
- Spartin
- AP-5 complex subunit zeta-1
- Patatin-like phospholipase domain-containing protein 6
- Gap junction gamma-2 protein
- Magnesium transporter NIPA1
- Semaphorin-6D
- Zinc finger FYVE domain-containing protein 26
Sequence:
MGEIKVSPDYNWFRGTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ
Protein: LD42037p (Uncharacterized protein, isoform A) (Q9VHH1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH10201p
- NAD
- GH09530p
- GRAM domain containing 1B, isoform E
Sequence:
MYVRRALLLACLLCLQPLGPSMASEDESNPLLDMASMFFQEALSNQNGGNNGGGGAGLAGVASLIGTFMQASGKSGGAGAGGGGAGGAMQILSGLGSLLSKSQGGQSGGFDPSIIGNVLEMFTQGDDEEATPQQKRSNGGGSESGIGLDTILQVASAFMNTQGNDKATHHHQQKRSTATEPESENGLMNLLPLVMQAVSSFAGPEGQSTQEKHKSHAWVLPPFLEHIHVLWDHFSNSELADALYEKSGVNKIMKGFKGSDGKLDYDKLFESLNNQSFRRRWIKSATLYLADWASYLANPEVYLRYFQTAQIMFNGLLKSQGYPKQTHFDPSRPGETISNLLDHVAKHHLNVKIDSRQYVKPAVGYAKELLKLGQARGLLQFNATEISDKLTDTLNLEVIEPVLKVHRAYRYISKSPQCDRYVLCQLNAAALDQQEKQRQHDQYQQHHQPKQSQLNRPTSASSLIAGVSPKIVKIGSMGAAIFISTETGTPFWTLFGVINAPYNCEAKYPVDCNGFHEGEAKVTTEYIHNEL
Protein: AP2-like ethylene-responsive transcription factor BBM (AtBBM) (Protein AINTEGUMENTA-LIKE 2) (Protein BABY BOOM) (Q6PQQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that, in opposition to HDG1, promotes cell proliferation and morphogenesis via transcriptionnal activation of meristem and cell proliferation genes, but prevents differentiation, especially during embryogenesis. Binds to the promoter and triggers the expression of epidermally expressed genes such as GSO1, GSO2, ACR4 and WER, and of HD-ZIP homeobox genes including PDF2, HDG1, HDG5, HDG7, HDG8, HDG11, ANL2, PDF2 and ATML1.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein RKD4
- Probable polyol transporter 3
- Carboxylesterase 20
- Probable polyol transporter 4
- Agamous-like MADS-box protein AGL15
- Protein TIME FOR COFFEE
- TIC-like protein
Sequence:
MNSMNNWLGFSLSPHDQNHHRTDVDSSTTRTAVDVAGGYCFDLAAPSDESSAVQTSFLSPFGVTLEAFTRDNNSHSRDWDINGGACNNINNNEQNGPKLENFLGRTTTIYNTNETVVDGNGDCGGGDGGGGGSLGLSMIKTWLSNHSVANANHQDNGNGARGLSLSMNSSTSDSNNYNNNDDVVQEKTIVDVVETTPKKTIESFGQRTSIYRGVTRHRWTGRYEAHLWDNSCKREGQTRKGRQVYLGGYDKEEKAARAYDLAALKYWGTTTTTNFPLSEYEKEVEEMKHMTRQEYVASLRRKSSGFSRGASIYRGVTRHHQHGRWQARIGRVAGNKDLYLGTFGTQEEAAEAYDIAAIKFRGLSAVTNFDMNRYNVKAILESPSLPIGSSAKRLKDVNNPVPAMMISNNVSESANNVSGWQNTAFQHHQGMDLSLLQQQQERYVGYYNGGNLSTESTRVCFKQEEEQQHFLRNSPSHMTNVDHHSSTSDDSVTVCGNVVSYGGYQGFAIPVGTSVNYDPFTAAEIAYNARNHYYYAQHQQQQQIQQSPGGDFPVAISNNHSSNMYFHGEGGGEGAPTFSVWNDT
Protein: Wilms tumor protein homolog (P22561)
Organism: Mus musculus (Mouse)
Function: Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Subcellular location: [Isoform 1]: Nucleus speckle.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleoplasm.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14681305}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:14681305}. Nucleus speckle. Note=Shuttles between nucleus and cytoplasm. {ECO:0000269|PubMed:14681305}.
Interaction partners:
- Transcription factor GATA-4
- Steroidogenic factor 1
- Cellular tumor antigen p53
- Pre-mRNA-splicing regulator WTAP
- Nephrin
- Podocin
- Sex-determining region Y protein
- Methylcytosine dioxygenase TET2
- Nuclear receptor subfamily 0 group B member 1
- Transcription factor 21
Sequence:
MGSDVRDLNALLPAVSSLGGGGGGCGLPVSGARQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTLHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPTIRNQGYSTVTFDGAPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGMAAGSSSSVKWTEGQSNHGIGYESENHTAPILCGAQYRIHTHGVFRGIQDVRRVSGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWHSCQKKFARSDELVRHHNMHQRNMTKLHVAL
Protein: Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (Sm-D autoantigen) (snRNP core protein D1) (P62314)
Organism: Homo sapiens (Human)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (Probable).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:21113136, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
Interaction partners:
- Cell division cycle 5-like protein
- Pre-mRNA-processing factor 6
- Small nuclear ribonucleoprotein-associated proteins B and B'
- Small nuclear ribonucleoprotein E
- Pre-mRNA-splicing factor SYF1
- Small nuclear ribonucleoprotein Sm D3
- Gem-associated protein 2
- U2 small nuclear ribonucleoprotein B''
- U4/U6.U5 tri-snRNP-associated protein 1
- Protein BUD31 homolog
Sequence:
MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVSMNTHLKAVKMTLKNREPVQLETLSIRGNNIRYFILPDSLPLDTLLVDVEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR
Protein: Uncharacterized protein UNK4.17 (O14082)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotically up-regulated gene 110 protein
- Glutamyl-tRNA
Sequence:
MMQNIKDEAYKTYQNVKDEISSHLPQSAPEPTGPPFKCAIFGCGGINFGTAEGPWNNSQKLELVLGHRLQVVALLSPHKSSHERVLKQKAETEYASSYANTREFYSADEYLEYLDSHPEEKPDAYIIGIPPETHGSTQKGADLELAILKRFPDASLFIEKPISAAPVEDAFAVARRLPSESVISVGYMLRYLKTVQKAKEIIKEKNLKVVSTVAKYNSAYIHNSKKFWWIMSESGGPVVEQGTHFCDLSRYFGGDVEIDSIKVNRVEWDDPSGKLNAMPVDEKTIPPEERIPRFTAASWKYKDGGVGAFTHNITLQGAKYDTCIEVQADGYYLRIVDLYEEPVLYVRSPDSDEEKVYKYPNDDPYYSEFKIFLDAAEGKGDKNLIHSDFLDAVKTYELTKAITEAK
Protein: Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) (P08207)
Organism: Mus musculus (Mouse)
Function: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Interaction partners:
- Annexin A2
- AHNAK nucleoprotein
- Demilune cell and parotid protein 1
- Tissue-type plasminogen activator
- Plasminogen
- AHNAK nucleoprotein 2.
- Annexin A1
- Protein S100-A6
- 5-hydroxytryptamine receptor 1B
- Helicase-like transcription factor
Sequence:
MPSQMEHAMETMMLTFHRFAGDKDHLTKEDLRVLMEREFPGFLENQKDPLAVDKIMKDLDQCRDGKVGFQSFLSLVAGLTIACNDYFVVNMKQKGKK
Protein: Selenoprotein Pa (zSelPa) (Q98SV1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium.
Subcellular location: Secreted {ECO:0000269|PubMed:11168591}.
Interaction partners:
- FAU ubiquitin-like and ribosomal protein S30 fusion a ubiquitously expressed
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit E-A
- Eukaryotic elongation factor, selenocysteine-tRNA-specific.
- Eukaryotic translation initiation factor 3 subunit D
- Small ribosomal subunit protein eS1
- Eukaryotic translation initiation factor 5
Sequence:
MWKALSLTLALCLLVGCSAESETEGARCKLPPEWKVGDVEPMKNALGQVTVVAYLQASULFCLEQASKLNDLLLKLENQGYPNIAYMVVNNREERSQRLHHLLQERLLNITLYAQDLSQPDAWQAVNAEKDDILVYDRCGRLTYHLSLPYTILSHPHVEEAIKHTYCDRICGECSLESSAQLEECKKATEEVNKPVEEEPRQDHGHHEHGHHEHQGEAERHRHGHHHPHHHHHHHRGQQQVDVDQQVLSQVDFGQVAVETPMMKRPUAKHSRUKVQYSUQQGADSPVASUCUHURQLFGGEGNGRVAGLUHCDEPLPASUPUQGLKEQDNHIKETUQURPAPPAEUELSQPTUVUPAGDATUGURKK
Protein: PPE family protein PPE34 (Q79FI9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. Interacts with human Toll-like receptor 2 (TLR2) and triggers functional maturation of human dendritic cells (DCs), leading to secretion of IL-4, IL-5 and IL-10 from CD4(+) T cells and induction of Th2 immune response. Maturation of DCs involves PI3K, ERK1/2, p38 MAPK and NF-kappa-B signaling pathways.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20837474}. Secreted, cell wall {ECO:0000269|PubMed:11800581, ECO:0000269|PubMed:20837474}. Cell surface {ECO:0000269|PubMed:11800581}.
Interaction partners:
- PPE family protein PPE35
- Outer membrane channel protein CpnT
- Uncharacterized protein Rv2082
- Uncharacterized protein Rv2209
- ESX-1 secretion-associated protein EspE
- PE-PGRS family protein PE_PGRS48
- PE-PGRS family protein PE_PGRS30
- Probable membrane protein
- PE-PGRS family protein PE_PGRS15
- PE-PGRS family protein PE_PGRS28
Sequence:
MNFSTLPPEINSALIFGGAGSEPMSAAAVAWDQLAMELASAAASFNSVTSGLVGESWLGPSSAAMAAAVAPYLGWLAAAAAQAQRSATQAAALVAEFEAVRAAMVQPALVAANRSDLVSLVFSNFFGQNAPAIAAIEAAYEQMWAIDVSVMSAYHAGASAVASALTPFTAPPQNLTDLPAQLAAAPAAVVTAAITSSKGVLANLSLGLANSGFGQMGAANLGILNLGSLNPGGNNFGLGNVGSNNVGLGNTGNGNIGFGNTGNGNIGFGLTGDNQQGFGGWNSGTGNIGLFNSGTGNIGIGNTGTGNFGIGNSGTSYNTGIGNTGQANTGFFNAGIANTGIGNTGNYNTGSFNLGSFNTGDFNTGSSNTGFFNPGNLNTGVGNTGNVNTGGFNSGNYSNGFFWRGDYQGLIGFSGTLTIPAAGLDLNGLGSVGPITIPSITIPEIGLGINSSGALVGPINVPPITVPAIGLGINSTGALVGPINIPPITLNSIGLELSAFQVINVGSISIPASPLAIGLFGVNPTVGSIGPGSISIQLGTPEIPAIPPFFPGFPPDYVTVSGQIGPITFLSGGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGAIGPLTTPPITIPSIPLGIDVSGSLGPINIPIEIAGTPGFGNSTTTPSSGFFNSGTGGTSGFGNVGSGGSGFWNIAGNLGNSGFLNVGPLTSGILNFGNTVSGLYNTSTLGLATSAFHSGVGNTDSQLAGFMRNAAGGTLFNFGFANDGTLNLGNANLGDYNVGSGNVGSYNFGSGNIGNGSFGFGNIGSNNFGFGNVGSNNLGFANTGPGLTEALHNIGFGNIGGNNYGFANIGNGNIGFGNTGTGNIGIGLTGDNQVGFGALNSGSGNIGFFNSGNGNIGFFNSGNGNVGIGNSGNYNTGLGNVGNANTGLFNTGNVNTGIGNAGSYNTGSYNAGDTNTGDLNPGNANTGYLNLGDLNTGWGNIGDLNTGALISGSYSNGILWRGDYQGLIGYSDTLSIPAIPLSVEVNGGIGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPITVPGVPISRIPLTINIRIPVNITLNELPFNVAGIFTGYIGPIPLSTFVLGVTLAGGTLESGIQGFSVNPFGLNIPLSGATNAVTIPGFAINPFGLNVPLSGGTSPVTIPGFAINPFGLNVPLSGGTSPVTIPGFTIPGSPLNLTANGGLGPINIPINITSAPGFGNSTTTPSSGFFNSGDGSASGFGNVGPGISGLWNQVPNALQGGVSGIYNVGQLASGVANLGNTVSGFNNTSTVGHLTAAFNSGVNNIGQMLLGFFSPGAGP
Protein: Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (Serine-palmitoyl-CoA transferase 1) (Q6NUL7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNRSIALTRARYLEKEEKCLPPPRGRTGESCVHHQGGSPGRPALGRVPGPWPPATQHAERTQDSRWPWSGLKESKNMWIFDRIVTKWCQYGPIV