wanglab/gogpt-training-data huggingface dataset:
Protein: Triggering receptor expressed on myeloid cells 2 (TREM-2) (Triggering receptor expressed on monocytes 2) (Q99NH8)
Organism: Mus musculus (Mouse)
Function: Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (By similarity). Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade. Required for microglial phagocytosis of apoptotic neurons. Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain. Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide. It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB. During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling. Plays a role in microglial MTOR activation and metabolism. Regulates age-related changes in microglial numbers. Triggers activation of the immune responses in macrophages and dendritic cells (By similarity). Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages. In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). Involved in the positive regulation of osteoclast differentiation.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:16715077, ECO:0000269|PubMed:24990881}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
Interaction partners:
- TYRO protein tyrosine kinase-binding protein
- High affinity immunoglobulin epsilon receptor subunit gamma
- Apolipoprotein E
- Transcription initiation factor IIA subunit 2
- Tyrosine-protein kinase SYK
- Clusterin
- Myeloid cell surface antigen CD33
- Triggering receptor expressed on myeloid cells 1
- Plexin-A1
- Semaphorin-6D
Sequence:
MGPLHQFLLLLITALSQALNTTVLQGMAGQSLRVSCTYDALKHWGRRKAWCRQLGEEGPCQRVVSTHGVWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQAGDAGLYQCQSLRGREAEVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTSRNQETSFPPTSILLLLACVLLSKFLAASILWAVARGRQKPGTPVVRGLDCGQDAGHQLQILTGPGGT
Protein: S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) (A0A1D8PU61)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- S-formylglutathione hydrolase
- Pyruvate decarboxylase
- Pdc12p
- catechol O-methyltransferase
- Alcohol dehydrogenase 2
- alcohol dehydrogenase
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase domain-containing protein
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase domain-containing protein
Sequence:
MSESTVGKPITCKAAVAWEAAKPLVIEDVTVAPPKAHEVRIKVLYSGVCHTDAYTLSGVDPEGAFPVILGHEGAGIVESVGEGVTNVKPGDHVIALYTPECKECKFCKSGKTNLCGKIRATQGKGVMPDGTPRFTCKGKEILHFMGCSTFSQYTVVADISVVAINEKAEFEKACLLGCGITTGYGAATITANVQEGDNVAVFGGGCVGLSVIQGCKERKVNKIILVDINDKKEEWGKQFGATDFVNSTKLPEGTTIVDKLIEMTDGGCDYTFDCTGNVNVMRNALEACHKGWGTSIIIGVAAAGKEISTRPFQLVTGRVWKGAAFGGVKGRSQLPGIVEDYLDGKLKVEEFITHREPLDKINTAFDEMHGGDCIRAVVSLW
Protein: Protein transport protein Sec61 subunit beta (Q7JZN0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
- Protein transport protein Sec61 gamma-2 subunit
- DSec61alpha
- RE14391p
- Protein transport protein Sec61 gamma-1 subunit
- Protein transport protein Sec61 subunit gamma
- Translocon-associated protein subunit beta
- Translocon-associated protein subunit gamma
- Translocon-associated protein subunit delta
- Translocation protein SEC62
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Sequence:
MPAPASSTSVGSGSRSPSKLSAPRSAGSGGGSTLKQRKTTTSTTAARSRAPGGAGTGGMWRFYTDDSPGIKVGPVPVLVMSLLFIASVFMLHIWGKYNRS
Protein: Myosin II homolog (Eurofung) (Q5B424)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Calmodulin, putative
- Calmodulin
- Actin, gamma
- Ras GTPase activating protein, putative
- Actin-related protein
- Tropomyosin TpmA
- Calmodulin
- Cell division control protein
- Actin cytoskeleton organization protein
- Aspergillus nidulans myosin V homolog
Sequence:
MLPSQINGSPKRANPFSRASPSPSPTPSPQTKARPKSAVLASAGKFEEPKSHIRNSSSISHTSLAPFGRNANRQRSNSLRNDVTSGTFAPEFIKSEDLRHGADQIRGQEGDNDFSGNKYVWLRDPEKAFVKGLVLEEQDGARLLVQTDDGQQREVDVDQVDRVNPAKFDKADDMAELTHLNEASVVHNLHTRYLADLIYTYSGLFLVTVNPYCPLPIYSNEYINMYKGQSREETRPHIFAMADEAFRNLVEEGENQSILVTGESGAGKTENTKKVIQYLAAVATSDNMYSRSGSKQMNTLSQQILRANPILEAFGNSQTVRNNNSSRFGKFIRIEFSRSGQISGASIDWYLLEKSRVVKPNLQERNYHIFYQLLRGAEPKLKQKLLLSNLQIEDFAYTREGNDTIAGVSDEKEWDSLLEAFHIMNFSEEDQMCILRTVAAVLHLGNITIVKESLRADQAALSRDALDSVHKACQLLGIETEPFVKGLLHPKVKAGREWVEKVQTPEQVRLALDALAKGIYERGFGDLVNRINSRLERNTVTGEDSYFIGVLDIAGFEIFQNNSFEQLCINYTNEKLQQFFNHHMFVLEQEEYAREQIEWQFIDFGKDLQPTIDLIEVTNPIGIFSCLDEDCVMPKATDKSFTEKLHSLWDTKSTKYRASRLRQGFILTHYAAEVEYSTDGWLEKNKDPLNDNITRLLASSQDNHIAALFSDCGNADEVDHPRSRVKKGLFRTVAQRHKEQLSSLMNQLHSTHPHFVRCIIPNHKKRPKMLNAPLVLDQLRCNGVLEGIRIARTGFPNRLSFNEFRQRYEVLCRDMPKSYMDGQSAARIMLQKLALDKAWFRVGRTKVFFRAGVLAELEEKRDELIRTIMTRFQSVARGFVQRRISNKRLYRAEATHIIQHNFRAYLEMKANPWWRLFSRMKPLLGETRTAQEVKRRDEKIKQLETKMKQDQSERQKVEEERRRAEIEIQRIQQTLESERALALDKEEIFKRLQDREVELSEKLAGAIADQENLEDQLDELILAKKKTDEELDLRKTQLEQAGEIIQRLEAERKEMQQKLEDLEQKLLEAQSSASETENHMRELGQEVKMLQSHLSLKERKLQDLEAKLLKTDQDLDVKLAKTSKELDRSKKEVKDLLDENRTIRQQISDLSKTSTSYEEMLRRKESELTVLRNDAKKHAEEKKQLDVEKSNLSTRHDNMQNKLRELQAQVDAMVSEKIQLEREAADVQKLLQAKISEDAEAGESRKLLEQQIQDLKNQLFQAQADLSRERQSRDDVQMLAEHKLAELKDKFESLNEAKITIEKEMYIQQDSLRRATEARVAAEQSRKELQQELIKLRDRFTAAEDARLRAEAEMEQALVKQTTQRLESIRKELDNTQHRLEEVEAERSRLAAREQQLMNAIAESESFRIRHDQHKERLERELVTLKGRLTASENDNRALLTKIQQKNLDIARSNSKASESQRLRVATLQKEKAKLEEENKALSRQLGDQQLSITSLEKQKEKLALSVEDLNHEVNREHKASRNAERAASTASIQLAEANRNLETERQLRTQAQANTRKLQSALDSSNKEIDDLHRQLMLFHKIVEPEADPSADSWDKIQPDLSRKVDLAQLVETLQSQLQVSEEKYNRAEAQLAEMRRRHGEEMKELDARYSSSKRALLEEIDQNEVAHNRTPNHLRKNSETAIAKKFGAPTTPNRRLNINDNSNDSARSDRTVDTVGYQKRMDLAAEIEELQNKLQMSEMQNKHLQDQLARSVPPKDIWQDDSPSIRRMQLLERENGRLHEQLDDSSKKVSALERSIHSGELSLRDVQAKSHEELYDLINSQEQSRRSLLRVHNETVAEITDAKAQFEKLKRAKAALEVELRDACSEAQELQAAREQDALSRNQLLQEFSDLQIRLDAETSKSADLAASLSLYKSRADEYFSKLEQAEITLLKASRAEQFAKAQAKETEDNCAQIMAERKEMEAIIDDLQRQTQSLEARMEDQAAELQGALQAKQRLQNELEDYRNQRAIDIEDKETSMEQTRQKYQREITTLNNELEMEREKVLNGRTEASRLREELEDLRSKWDNEVLNSSTWAKEKSRMEVMLQDVTTSRDEAVNAHNDAQARVVSLLSQVRSLRTSIDDVTAERDMLHKEKKMLEARLTEAGERLEDLAKGESPSMRNAASMDRELLELKAKLAQQEDLSLAAVGKMRRAEALATEMQKEVTAEREATAQLFKDKAALEKQLKEAQLRCVDLETKSYSSGSQDIRFLHKRIKELETHLEEQEAKNNSEQRSLRNVDRTVKDLQSQIERREKMNAQLEEEVNRGREKVERLLKNIDELQQSESDSQLQARRAERELREEREKSLRLERELNGWKALRVERGGSAIARSHVAFSDAGSRKGSGAYTTGDLHRMPSNTKGFL
Protein: Exonuclease DPD1, chloroplastic/mitochondrial (EC 3.1.11.-) (Mg2+-dependent DNA exonuclease) (Protein DEFECTIVE IN POLLEN DNA DEGRADATION 1) (Q682U6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Exonuclease required for organelle DNA degradation during pollen development. Plays non-essential roles in maternal inheritance. May be part of the DNA salvage machinery.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:21521697}. Mitochondrion {ECO:0000269|PubMed:21521697}.
Interaction partners:
- NADPH--cytochrome P450 reductase 1
- Proliferating cell nuclear antigen 2
- Proliferating cellular nuclear antigen 1
- Vacuolar fusion protein MON1 homolog
Sequence:
MCISISQVSRLRIHSFGSSCCERVHGWIKNSSSLKLLDVRASSVDGKARWIRRNVSTTTQGSRSNTKSSVLGGTVPVTRIIDEESRTKVQPFGNLQQRLAQDKDLSKLLTVIVSDLETTGLHRKNERIIEIAAQDIAGGGYSTFQTLVNPGVVPITNAHIHGIRNDMVCRPEVPRMEELIPIFLRYVESRQKPGGYVMLVAHNGKSFDFQFLINEFNRCSYEIPHNWLLLDSLPLARENMKSVEPTVKLSSSLEALADYYSLTREGDAHRALSDVLLLSKVFQKLTIDLKLSLSDLVLRCHTASDISAAMAKNKKA
Protein: Corin, serine peptidase (A0A087X1D5)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVGACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCACHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWIKRQIYIQTFLLN
Protein: Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4) (P48050)
Organism: Homo sapiens (Human)
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P52189}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P52189}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P52189}. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization. {ECO:0000250|UniProtKB:P52189}.
Interaction partners:
- ATP-sensitive inward rectifier potassium channel 12
- Inward rectifier potassium channel 2
- Potassium voltage-gated channel subfamily KQT member 2
- Potassium voltage-gated channel subfamily KQT member 1
- Potassium voltage-gated channel subfamily KQT member 3
- Potassium voltage-gated channel subfamily KQT member 4
- Disks large homolog 4
- Potassium voltage-gated channel subfamily KQT member 5
- Guanine nucleotide-binding protein G
- ATP-sensitive inward rectifier potassium channel 14
Sequence:
MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI
Protein: Pre-rRNA-processing protein tsr2 (Q9UUA9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for 20S pre-rRNA processing.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable assembly chaperone of rpl4
- Ankyrin repeat-containing protein P16F5.05c
- Ribosome assembly protein rrb1
- Small ribosomal subunit protein eS26A
- Small ribosomal subunit protein eS26B
- Uncharacterized protein C18B11.06
- DNA-directed RNA polymerase I subunit rpa43
- Ribosome biogenesis protein tsr1
- Ribosome production factor 2 homolog
- U3 small nucleolar ribonucleoprotein protein imp4
Sequence:
MFDDPSKRLTYFEYAVGVLLCSWPVMKQAVEEEWADVDTADKRDWMAGVLVDYITVTSDVEAWDVEELILQVLQDEFNVGSIEDDSPYILAQDLVNVWKAACEDNYEPIREIHERLGKQLLEKEEGKEKTREESNPPVLVEDETIVDAEDGGAAQNQQEKQQGPIVDDDGFTVVQKRRR
Protein: G1/S-specific cyclin CLN1 (P20437)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.
Interaction partners:
- Regulatory protein SWI4
- G1/S-specific cyclin CLN2
- SCF E3 ubiquitin ligase complex F-box protein GRR1
- Cyclin-dependent kinase 1
- Regulatory protein SWI6
- Transcription factor MBP1
- Protein BCK2
- G1/S-specific cyclin CLN3
- Protein SIC1
- Protein phosphatase PP2A regulatory subunit B
Sequence:
MNHSEVKTGLIVTAKQTYYPIELSNAELLTHYETIQEYHEEISQNVLVQSSKTKPDIKLIDQQPEMNPHQTREAIVTFLYQLSVMTRVSNGIFFHAVRFYDRYCSKRVVLKDQAKLVVGTCLWLAAKTWGGCNHIINNVSIPTGGRFYGPNPRARIPRLSELVHYCGGSDLFDESMFIQMERHILDTLNWDVYEPMINDYILNVDENCLIQYELYKNQLQNNNSNGKEWSCKRKSQSSDDSDATVEEHISSSPQSTGLDGDTTTMDEDEELNSKIKLINLKRFLIDLSCWQYNLLKFELYEICNGMFSIINKFTNQDQGPFLSMPIGNDINSNTQTQVFSIIINGIVNSPPSLVEVYKEQYGIVPFILQVKDYNLELQKKLQLASTIDLTRKIAVNSRYFDQNASSSSVSSPSTYSSGTNYTPMRNFSAQSDNSVFSTTNIDHSSPITPHMYTFNQFKNESACDSAISVSSLPNQTQNGNMPLSSNYQNMMLEERNKENRIPNSSSAEIPQRAKFMTTGIFQNTGELTNRASSISLSLRNHNSSQL
Protein: Protein TIC 56, chloroplastic (Translocon at the inner envelope membrane of chloroplasts 56) (AtTIC56) (Q7Y1W1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000269|PubMed:23372012}.
Interaction partners:
- Protein TIC 100
- Protein TIC 20-I, chloroplastic
- Protein TIC 214
- Translocase of chloroplast 159, chloroplastic
- Translocase of chloroplast 34, chloroplastic
- Protein TOC75-3, chloroplastic
- Protein TIC 40, chloroplastic
- Translocase of chloroplast 33, chloroplastic
- Protein TIC110, chloroplastic
- Probable inactive ATP-dependent zinc metalloprotease FTSHI 2, chloroplastic
Sequence:
MSSMNFNPFQNWFEKPPNPVPSINFVSLADSFFPKSQSPNFASIGLPKFSKKSPKPETAGTDEPGPYKQIAEQFLWECENIPDYRHTPEVDKLLNEDPVFEKKENPSTEEIEAEQKWWESFRASPVVQFMTRAEEIADDMNKMELEDNDTPYRKEDKDYWRAIPHVPGFDGRPMPRKAIKSKEESDDKFWDFMKQFLFGLWGFRQRPYPPGRPIDVAQAIGYKRLEKRYYDFIMKTGGWWYKDRLGRSRGPCEIITLKTAYGAGIIDRDTFIWGEDMDEWAPIHMVYGLEPAIATWEVRLGAAATAFLHKLQKGIPPWVPLKGREPKTYKQLQKEAIESKKRDMAVLEANGGVWPGVRTPSHALFLWASGSELTTVLESDHMPNKFIPKQLRLELAKVIPGLRPWEVISIEQAMDQISYGGEWYREPLGTYTTGPPYIREWNRSVMRLFRIFYNLSVRVGQKLERTVPGFDTIMDKVQKDYDKRIARRMKRREEELREEDLKHYSGRTDEDEEEEEEEDDDSNSKKD
Protein: Myosin XVIIIAa (A0A0R4J7R2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Myosin, light chain 1, alkali; skeletal, fast
- Zgc:153867.
- Myosin light polypeptide 6 isoform X1
- Atrial myosin light chain
- Myosin, light chain 4, alkali
- Myosin, light chain 9a, regulatory
- Myosin, light chain 12, genome duplicate 2
- Myosin, light chain 12, genome duplicate 1
- Myosin regulatory light polypeptide 9b
Sequence:
MFHLIKKDKDKEKDGAKKEKKEKKEKKERMSQAELKSLEEMSVRRGFFHLHRSNSKRETKGKLEISSPIPIKVVRNTELSLADVDLRKLYSQGSVTPTSSSDDIKGEQDVRRSSVKEQAAKFDSITKQNSQVENMLKRYSFSQRSKEESPSGSTAPSGQNSAIASPQIEVKVFNQSTLHSFHQTSPAKIVQIPEIVDRTFPADLRLPAVAPPQVPAPRELEIQRRNTGDFGFSLRRTTMVDQRTDGSLYRKVVHFAEPGAGSKDPTLGLVPGDRLVEINGRNVENKSRDEIVEMIRQSGDTVRLKVQPIVELSELSRCWLRNTKGPYREVYEVKTEEQLAAEKAWYNTEKVWLVHKDGFSLATQLKTDTGSLPEGKVKIRLEHDGTLLEVDEDDVEKANPLSYDRVEDLSSLLYLNESSILHSLRQRYGGNLIHTYAGPNLLLINPLCSPAMYSEKVMQMFKGCRREETAPHIFAVAQSAYHQLLTTRQDQTIVLLGRSGSGKTTNTQHLLQYLVTIAASSGKVYSAEKWQAVYTVLEAFGNCSTAMNGNASRFSHIVSLDFDQAGQVASASVQTMLLEKFRVTRRPEGESSFNVFYYLMAGADAALKTELHFNHLAENSTFGLHPPSKLDDKQKATQQFTKLQAAMKVLGVSPEELKTVWLILGAIYHLGAAGATKETDAAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKPQGKGTLPRSASLRPSTEDTDHAASKATAAECLESMAAGLYSELFTLIISLINRALKSSQHSLCSLLIVDTPGFQNPRQVKTQIQRSATFEELCHNYAQERLQTLFQERTFVKELERYKEENIEITLDDLEPSPSRSVAVIDQSSSQTLVRTLSRTDEARGLFWLMEEEVLQPGGSEETLLQRLFSYYGPAEGESTGHTVVLKSENTNHFVLGHSHGTDWVEYDTYGWLNLARLNPTPQNAANLLLNSQKKSISGMFVGRSSSAAVLTGSIAGLEGVSQLAMRRATSMRKTFTTGMAAVKKKSLCLQIKLQVDALLDTIRRSKVHFVHCLLPRAEVLRAAGSPDESCDPGLMQIDVALLRAQIHGFKLLDSLRIYRQGYPDHMVFSEFRRRFDVLAPHLTKKLGRNYIVKDEKRAVEELLESLELEKSSYHMGLSRVFFRAGTVAKLEAQRDEHTRQNITLFQAACRGFLSRQAFKKRKIQDLAIRCVQKNIKKNRGVKDWPWWKLFTTVRPLVEVQLTEEQIRGKDEEIMHMKLKLERVEKERNELRLTSDRLESRITELTAELSDERNTAESTSQLLETETSERLRLEKDMKDLQVKFDALKKQTESMEMEIMEARLLRASDLNGEMDDGDDDSGGEWRLKYERAIRDTEFTKKKLQQEMDDKLETEQQNKRHLERKLADLQADQEESQRSVQQLKKKCQRLAAELQDTKLHLENQEGRNHELERKQRKFDVDKSQVQEELQKERNQREKLSRERDMLTSEMFTIKQQLQEKDTELCTVSLKVEQLESELQDLSSQESKDEASHAKVKKQLRDLEAKVKDQEEELDEQAGSIQMLEQAKLRLEMEMERLRQTHSKELDSKDEEVEEIRLSCSKKLKQMEVQLEEEYADKQRVLRDKRDLESKLMTAQEQVGQKDVETEKRLRKDLKRTKVLLADAQIMLDHMKSNVPSKREIATLKNKLEESEFACAAAVKARKSMELEIEDLHIQMDDISKAKMSLEEQLSRLQREKNDLQSRFEEDQEDMNELMKKHKAAVAQSTRDLAQISDLQTQVEEAMKEKQEIQDKLHSLQSQLEFQEQSMVEKSLVSRQEAKIRELETKLEYERTQTKRLESLVTRLKENLEKMTEERDQRVGCENREKDQNKRLQRQIRDIKEEMTELSKKEAEASRKKHELEMDIESLEAANQSLQADLKLAFKRIGDLQAAMEDEMETDDDDDLINSLQDMVTKYQKRKNKTGDESDMDSEVEDRVDGVKSLLSKSKGSTKTLSDDGPQKTTRHPNSANADVKDVKEGKEGKEDVKKDSDESRSVSVISSLSYRKRAHQKDWNGGAGDETSLFSALREQPEMPDRLSLRKAKTKSTDRPGDDLDDRGSVISQAYSEAAIRARKGLDRRWTKSSPEFDKESMVSSVAPSRASTRRGIDEDEDARSGVSSFSLRRSTSWIDDSRSDYGSASTSHRQRSRSRSPGSTSVGSRISLARSTRLSEFGVRLNNDDVDEDDDVDSVSVAAYSPRSQGRSLSTPAQMRSSESPVDASDIKPVSHRNYLDPDLEKAINEVLSFKPIKFKRRSLEDSDEELEGGGGAGEDEDRKGTKSLLQDKDDKDLGLTRSALDSGRSGSSMSSFSSKSSRRKNKKKSRRSESDSSSNEGHSRRHSKRKDKRGSRNSRKKESGSSKSESESSSSSSASTVSYRSSNSVKRTTNQKASDGDRESPVEERPPSKKEVKKQKKKVDNLVMKYLYKPDSD
Protein: Insertion element IS1 1 protein InsA (IS1a) (P0CF07)
Organism: Escherichia coli (strain K12)
Function: Absolutely required for transposition of IS1.
Interaction partners:
- Insertion element IS1 1 protein InsB
- Insertion element IS1 2 protein InsA
- Insertion element IS1 4 protein InsB
- Insertion element IS1 2 protein InsB
Sequence:
MASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHLKNSGRSR
Protein: Resistin (Q70Q42)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKNTVLHCWSVSSRGRLASCPEGTTVTSCSCGSGCGSWDVREDTMCHCQCGSIDWTAARCCTLRVGS
Protein: Histamine H1 receptor (H1R) (HH1R) (P30546)
Organism: Bos taurus (Bovine)
Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1722337}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35367}.
Interaction partners:
Sequence:
MTCPNSSCVFEDKMCQGNKTAPANDAQLTPLVVVLSTISLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGVVVMPMNILYLLMSRWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLKYLRYRTKTRASITILAAWFLSFLWIIPILGWRHFQPKTPEPREDKCETDFYNVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINGSFPSFSDMKMKPENLQVGAKKPGKESPWEVLKRKPKDTGGGPVLKPPSQEPKEVTSPGVFSQEKEEKDGELGKFYCFPLDTVQAQPEAEGSGRGYATINQSQNQLEMGEQGLSMPGAKEALEDQILGDSQSFSRTDSDTPAEPAPAKGKSRSESSTGLEYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFIICWIPYFIFFMVIAFCESCCNQHVHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
Protein: Protein kinase PINOID (OsPID) (EC 2.7.11.1) (Q2QM77)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Serine/threonine-protein kinase involved in the regulation of auxin signaling. May control polar auxin transport and probably plays a role in the pattern formation and organogenesis in the rice shoot.
Interaction partners:
- Transcription factor LAX PANICLE 1
Sequence:
MVAAVRAPVKPEMVELSPAAMERYSSDADTTAPNSSLSSAASSTGSLARCSSLSRLSFDCSPSAAVAAAATSCSPPRASVLLRPHRSGDVAWAAIRAASTTSAAPLGPRDFKLVRRIGGGDIGTVYLCRLRSSPERESPCMYAMKVVDRRAVARKQKLGRAAAEKRILRQLDHPFLPTLFADFDATPHFSCAVMEFCPGGDLHSLRHRMPSRRFPLPSARFYAAEVLLAIEYLHMMGIVYRDLKPENVLIRADGHIMLTDFDLSLQSTTSPSLDGDTDTDDEASGGASCFPDHLLRFKRRRNAVAAPRPRFVAEPVDARSCSFVGTHEYVAPEVASGGAHGAAVDWWAYGVFLYELIYGRTPFAGATNEATLRNIVRRPLAFPSGSGSCGPADADARDLIARLLAKDPAARLGSRRGAADVKSHPFFKSLNLALLRSSRPPVVPGAGAGAAPLHRSQSCKAAPTTPPPPTTTKPANATARFDLF
Protein: WAT1-related protein At1g70260 (F4I5D5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable polygalacturonase At3g15720
- Protein GLUTAMINE DUMPER 1
- Cationic amino acid transporter 1
- Lysine histidine transporter 1
- Probable nucleoredoxin 1
Sequence:
MEVKVRRDELVPFVAMAIMEACTIALTIMAKTALTGGMSPFVFVVYTNAFGSILLLPFSFLFHRNERTEQSIFSWPLLVRVFFLGFTGIFMFQNLAFVGLRFSSPIVVCAMGLQIPSFSFLLSIILGRSKLDWRNTSTRAKLMGTIVSLSGAFVEELYKGPFIRPASSASPNRFLKSVPKLLVYYNLPDNWFLGCIFLAVAVFSVSLFNVVQTGTVKKYPHVMKVASFYSIVGTIQCLLFSLFMERDLSAWKIQPNFDLYLIIATGTFGSVIRTSVHVKCTQMKGPYYVPLFKPFGIFWATLFGTSFFVNSLHYGSVLGAAIAGVGYFTVSWGQLKESEEKQSSNEERKSIKTIHHRDEDEYKVPLLINQEESPV
Protein: Trans-ocimene synthase, chloroplastic ((E)-beta-ocimene synthase) (EC 4.2.3.106) (Terpene synthase 1) (LcTPS1) (G0Y7D1)
Organism: Litsea cubeba (Aromatic litsea) (Laurus cubeba)
Function: Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products used by traditional Chinese medicine to treat headache, inflammation and intoxication (Ref.1). Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) into (E)-beta-ocimene (Ref.1).
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MSLIIQSLPHWSRIPPRPPQLSQFQNSSRPKPLIQAGQVQHNALQIARRSANYHPSIWDPQYIESLKSPYGDECFGTRLEKLKFEAKRLLEATIEPLSWLELVDSIQRLGVAYHFEDEIKEGLDGVYGVGAHAGDDLYTAALQFRLLRQHGYGVTPDIFNKFLEKERTFKACTSLDAKGLLSLYEASHTMIHGEEVLEDAKEFSVKHLNYLMGNLQNNLREQVQHALEMPLHWRMPRLEAKHYIDVNGRSDERNMVLLELARLDFNFVQSKHQEELKEVSRWWRDLGLAKKLGFSRDRLVENYLWAVGIAPEPKFSNCRKGLTKLISILTVIDDIYDVYGSLDELELFTEAVKRWDIEALETLPEYMKICYLALFNFVHEVSYDTLKDYGWNILPFIREEWERLCMSYLVEAEWFGNGNKPALDEYLRNGWISVGGPVAMVHAYFLQGRPIRKDSINFLDHGSELIYWSSVATRLNDDLGTSKAEMKRGDVPKAVECYMIQTGESYEDAREHIQGLVRDCWKKMNEECLKCCLPKSYVETVLNMVRTAQCIYQHGDGIGTSTGVTQDRVISLICEPVPSQWP
Protein: Vasotocin VT1 receptor (Q9PTN7)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}.
Interaction partners:
Sequence:
MKNFSFPMQDSTHQTESPPHRLLSLTNKSDPVGRPERDEQLAQVEIAVLGVIFLTASVGNFILILVLWRRRKKLSRMYVFMLHLSIADLVVAFFQVLPQLIWDITDVFIGPDFLCRIIKYLQLLGMFASTYMIVVMTVDRYQAVCYPMVTFQKKRALWNIPICTSWSISLILSLPQVFIFSKIEISPGIFECWAEFIQPWGPRAYVTWILVVIFFIPSTILITCQVKICKIIKRNIYVKKQNEYQVTNQKQVLPSRASSVNCISKAMIKTVKMTIVTVVAYVLCWSPFFIAQLWSVWFPSGITEGSAFTIIMLLGNLNSCTNPWIYMYFCGHIPYCTNKQLENTSAQEDSVVTGSIHLVDRDPEENSTCA
Protein: Insensible, isoform A (Insensible, isoform B) (RE57682p) (Q7JZ51)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGKLIMKRKRASQEEQQQAQEQRVQPQEQQQEQQPTEAVPEKRHRPLTPPAEEPGQNCPNPPDAPNRILLEALQKIMELQAELDAFEQDLNDRDGYAAAGAEAEDVEESDEDAEVAAQFAPPTPAQRSQAEALGFAMCARETLLFLQSEGIPTESPLYQTLLGKLVGQSDGLLHA