wanglab/gogpt-training-data huggingface dataset:
Protein: Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (Q8SZZ8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ell-associated factor Eaf
- Little elongation complex subunit 1
- Uncharacterized protein, isoform D
- RNA polymerase II elongation factor Ell
- Cyclin-dependent kinase 9
- Cyclin-T
- AF4/FMR2 family member lilli
- ENL/AF9-related, isoform B
- Transcription elongation factor SPT5
- Negative elongation factor B
Sequence:
MFSMDSFAMDKDAKLYEGNALFRNQPSYKVFNKSFEHVDDALYTLLNEVEPDVLRMELQETGDLFKSFNRNSALRDPRNNEVPPKPTRDLTTASSLYSFPNPLEQYSELNLKQQAACMRVLLAWQCSQPVDEQDIVVWQATEKKRYNEQQRVQKYIHDHEQGRKEVIYAPMKSLVAVYRKWYELGVKKLQQTYPNDSYMTFSGLPQLPQCRSLNAQTASIEQVELERIVGRVRLLPEVEVRHEALRTLRLRLDRYATRETRAPVQLLREEDKELELEAGNVFVLPLDSLLMLLTTGSYIDLPTEMFLSLRESPNSKHKCMEFQSPFPPRNCGWHTNSLILKLAYGAYISQPGQAKWLDFNINGAVKEVPDEPACDKSSIDLQMVYKPRAIDQQPSDIEDGNCNSALVSWTLRCKGEGDDCNDFQIFSTLSIPAVKDSSGKEPLGCHFIKLENKPDCGCEIMSKYELISAWVQLKLMRAEMGHCTRISLRDFEPMLEEKLTLISLEQQLHDYYNTSMPQLLSNLCEFLKLLDTVPAGDYLLRYSPKYKDKFLLCIVTKEATPQSFQLHQLLTESIPSDQAFLTQSSYLPISPTLCGRLHEELHLLPCAFPAKANGRSVQRRKVVVPIPEPSRQAPVRRQRLKKWSEAQTREFRRRCKVDQKKRARARKTAAANKEKIELEKIMTL
Protein: Transcriptional regulator SarA (Staphylococcal accessory regulator A) (P0C1U6)
Organism: Staphylococcus aureus
Function: Global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner. In a strain-dependent manner plays a role in multidrug resistance mechanism. Is required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. Acts as a transcriptional activator of the genes encoding, among others, for fibronectin binding proteins (fnbA and fnbB), hemolysins (hla, hld, hlgB and hlgC), serine proteases (splA, splB, splD and splF) and of the bap gene, which is essential for biofilm development in some strains. Negatively regulates the expression of the genes for protein A (spa), lipase (lip), thermonuclease (nuc), immunodominant staphylococcal antigen B (isaB), staphylococcal serine and cysteine proteases (sspA and sspB), staphostatin B (sspC), metalloprotease aureolysin (aur) and collagen adhesin (cna). Probably activates the development of biofilm by both enhancing the ica operon transcription and suppressing the transcription of either a protein involved in the turnover of PIA/PNAG or a repressor of its synthesis, whose expression would be sigma-B-dependent.
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
Protein: G1/S-specific cyclin pas1 (P87049)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the pef1 protein kinase. The pef1/pas1 complex activates the res2/cdc10 complex.
Interaction partners:
- Serine/threonine-protein kinase pef1
- ATP-dependent DNA helicase II subunit 2
- Tuberous sclerosis 2 protein homolog
- Glycerophosphocholine phosphodiesterase gde1
- Uncharacterized hydrolase C215.10
Sequence:
MSKVNMRALLESFSTVILSIYPLAKSTNQQSHSHSLSLTQFLYETIRRSRVDYTTLLLALYYFIRFRDAASSKPTNYIPLLCGRRLFLVCLMAATKFLQDRSFSNRAWSRLSGLPVDKLLVLEYMFYQCIDYRLVVPKHIFARWSLLVGECCAHATARYDSTDPNVASFGSVAQYWVSLFSNVQSSLDDLFSIACLTKIAHRRMNANAALKNQATRKPSSSPQTTQDSSPILTMAPSTPVSVGSTPPSTPSVLPIAKQLAPMNVCKAHIQASNQSRTLTTASPPEQIPLMEPQVYVNPQVLPGRLSSLSKPVSLPPTPSSPKVGVYRPMTSKSNGGVAYCYNAQKLNNATGPVTFNMPFASVLPLAVSVSCDLGTASAYVASLPQPCSQKRHLEEDYSCLTEHSAKRRSYF
Protein: Anti-Muellerian hormone type-2 receptor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII) (Q16671)
Organism: Homo sapiens (Human)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Muellerian-inhibiting factor
- Activin receptor type-1
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein receptor type-2
- Bone morphogenetic protein receptor type-1B
- Growth/differentiation factor 6
- Cell cycle regulator of non-homologous end joining
- TGF-beta receptor type-1
- Bone morphogenetic protein 6
- Bone morphogenetic protein 4
Sequence:
MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRCCFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPTILPCRPQRSACHFSVQQGPCSRNPQPACTLSPV
Protein: Effector TSP1 (Small secreted cysteine-rich protein) (SSCP) (G9MQD3)
Organism: Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens) (Trichoderma virens)
Function: Stimulates salicylic acid signaling in host plant roots.
Subcellular location: Secreted {ECO:0000269|PubMed:25681119, ECO:0000269|Ref.3}.
Interaction partners:
Sequence:
MQITKTLVATLFAASTAFAAPTPADKSMMAAVPEWTITNLKRVCNAGNTSCTWTFGVDTHLATATSCTYVVKANANASQASGGPVTCGPYTITSSWSGQFGPNNGFTTFAVTDFSKKLIVWPAYTDVQVQAGKVVSPNQSYAPANLP
Protein: SMP-LTD domain-containing protein (Q57Z99)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSAIYSLLFDSSSTLGVIIVSVVPWFVVLLYYLYYRIKRIGEVPPEVVAPLAHFLEVLTDGATAGYDKELMNLFHPELLTVRVERGVVRAMVRWVCDRLGKVTNIMRDAVLVKDDGDEAHIIALVDFEKVQQVKCRMSWKWRHTTGAAPRNQSSAKTEVSKRFFVTAFRFEPHTEVKSDVLQFLKTDDFIPFAEKFVERLFERPPKTAVEMMVPSLKDKYISNLDKLQGDVRGVCGPLLGGSVDVNCSLIDATVLRGPLSTAKEEGQTEEGVRGIEMSFFVSGVGCRNVNVNLLLVFADLRCYVGRYEVRVVPDTRTQVIVDRDTGEKTFIG
Protein: Beta-synuclein (Q7SX92)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Transmembrane protein 263
- Glutaredoxin and cysteine-rich domain-containing 1 a.
- Vesicle-associated membrane protein 2
Sequence:
MDVFMKGLSKAKEGMAVAAEKTKEGVAVAAEKTKEGVMFVGSKTKDSVATVAEKTKEQASQLGGAVMSGAGNIAAATGLVKKDEFPSDMNPEFGQEATEEPGEGLMDPEGQTYDDNQQESQDYEPEA
Protein: Guanine nucleotide-binding protein-like 3 (Nucleolar GTP-binding protein 3) (Nucleostemin) (Q8CI11)
Organism: Mus musculus (Mouse)
Function: May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation.
Subcellular location: Nucleus {ECO:0000269|PubMed:21132010}. Nucleus, nucleolus {ECO:0000269|PubMed:12464630}. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9}.
Interaction partners:
- Nucleolar GTP-binding protein 2
- GTP-binding protein 4
- Pescadillo homolog
- Probable rRNA-processing protein EBP2
- MKI67 FHA domain-interacting nucleolar phosphoprotein
- Ribosomal L1 domain-containing protein 1
- Protein SDA1 homolog
- Ribosome production factor 2 homolog
- mRNA turnover protein 4 homolog
- ATP-dependent RNA helicase DDX18
Sequence:
MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEALLREAELRKQQLEELKQQQKLDRQKEQERKRKLEVSPGDEQSNVETREESDEPKRKKAKAGKQNPKKLHCQELKKVIEASDIVLEVLDARDPLGCRCPQIEEAVIQSGSKKLILVLNKSDLVPKENLENWLNYLNKELPTVVFKASTNLKNRKTFKIKKKKVVPFQSKICCGKEALWKLLGDFQQSCGKDIQVGVIGFPNVGKSSVINSLKQEWICNVGISMGLTRSMQIVPLDKQITIIDSPCLIISPCNSPTALALRSPASIEELRPLEAASAILSQADNEQVVLKYTVPEYKDSLHFFTKLAQRRGLHQKGGSPNVESAAKLVWSEWTGASLGYYCHPPASWNHSLHFNENIAAVMKKGFNLEELEKNNAHSIQVLKGPHLTNRILFRSSGLTNGILDEKDIVEESPRQTEDKQDADDQENGSGERNAEISDVAPVEETRELSPEQSTAGKPSDGSSALDRASQEDETYDFTTDYI
Protein: Putative citrate synthase 2 (EC 2.3.3.16) (P9WPD3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Aconitate hydratase A
- Malate dehydrogenase
- Multifunctional 2-oxoglutarate metabolism enzyme
- Malate synthase G
- Acetyl-coenzyme A synthetase
- Citrate synthase 1
- Fumarate hydratase class II
- Dihydrolipoyllysine-residue acyltransferase component of branched-chain alpha-ketoacid dehydrogenase complex
- Pyruvate carboxylase
- 2-oxoglutarate oxidoreductase subunit KorA
Sequence:
MTVVPENFVPGLDGVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQRVTFGDVWALLVDGNFGSGLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPLLDIDDATARQQLARASVMALSYVAQSARGIYQPAVPQRIIDECSTVTARFMTRWQGEPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPLHGGAPARVLPMLDEVERAGDARSVVKGILDRGEKLMGFGHRVYRAEDPRARVLRAAAERLGAPRYEVAVAVEQAALSELRERRPDRAIETNVEFWAAVVLDFARVPANMMPAMFTCGRTAGWCAHILEQKRLGKLVRPSAIYVGPGPRSPESVDGWERVLTTA
Protein: AA9 family lytic polysaccharide monooxygenase B (LPMO9B) (EC 1.14.99.56) (Cellulase LPMO9B) (Endo-beta-1,4-glucanase LPMO9B) (Endoglucanase LPMO9B) (Glycosyl hydrolase 61 family protein LPMO9B) (Q5BCX8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.
Subcellular location: Secreted {ECO:0000269|PubMed:27588040, ECO:0000269|PubMed:35658600}.
Interaction partners:
- Uncharacterized protein
Sequence:
MKFSSVLALAASAKLVASHATVFAVWINDEDQGLGNTADGYIRTPPNNSPVTDVTSTDLTCNVNGDQAAAKTLEVAAGDKITFEWHHNSRDSSDDIIADSHKGPVLVYMAPTEAGSAGKNWVKIYEDGYNDGTWAVDTLIANKGKHSVTVPDVPAGNYLFRPEIIALHEGNREGGAQLYMECVQFKVTSDGTTQLPEGVSLPGAYTATDEGILFDIYSSFDSYPIPGPAVWDGASSGSGSSGSGSSSSAAATSSAEKTATSTTAAATTTAVATSTSSATQVQPTSVATFTTSVRPTTSAAPTTSAPTSSAAPTGGTGTGSIQIYQQCGGMNYKGATGCASGLTCKQWNPYYHQCVQA
Protein: T-cell ecto-ADP-ribosyltransferase 2 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 2) (ARTC2) (Mono(ADP-ribosyl)transferase 2B) (NAD(+) glycohydrolase) (EC 3.2.2.5) (T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2) (T-cell differentiation marker Rt6 homolog 2) (T-cell mono(ADP-ribosyl)transferase 2) (O35975)
Organism: Mus musculus (Mouse)
Function: Has both NAD(+) glycohydrolase and ADP-ribosyltransferase activity.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Nicotinamide phosphoribosyltransferase
- NAD-capped RNA hydrolase NUDT12
Sequence:
MTSKIFKFFLTWWLTQQVTGLAVPFMLDMAPNAFDDQYESCVEDMEKKAPQLLQEDFNMNEELKLEWEKAEINWKEIKNSTSYPAGFHDFHGTALVAYTGNLAIDFNRAVRDFKKSPDNFHYKAFHYYLTRAVQLLNDQGCSLVYRGTKVMFEYTGKGSVRFGQFSSSSLTKRVALSSNFFSNHGTLFIIRTCLGVNIKEFSSFPREEEVLIPGYEVYHKVTAQNDNGYNEIFLDSPERKKSNFNCFYNGSAQTVNIDFSISGSRESCVSLFLVVLLGLLVQQLTLAEL
Protein: Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) (Q9UQ26)
Organism: Homo sapiens (Human)
Function: Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Rap guanine nucleotide exchange factor 4
- Ras-related protein Rab-3A
- Protein unc-13 homolog A
- Protein unc-13 homolog B
- RIMS-binding protein 2
- Peripheral-type benzodiazepine receptor-associated protein 1
- Protein unc-13 homolog C
- Ras-related protein Rab-3C
- ELKS/Rab6-interacting/CAST family member 1
- Protein piccolo
Sequence:
MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKKVKEEHKPQLTQWFPFSGITELVNNVLQPQQKQQNEKEPQTKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSNTPQQPDQKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNGSGVKHHIASDIASDRKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSEKGDSQKGKRKTSEQAVLSDSNTRSERQKEMMYFGGHSLEEDLEWSEPQIKDSGVDTCSSTTLNEEHSHSDKHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS
Protein: DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) (Q6AXY4)
Organism: Rattus norvegicus (Rat)
Function: Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P49005}. Note=Recruited to DNA damage sites within 2 hours following UV irradiation. {ECO:0000250|UniProtKB:P49005}.
Interaction partners:
- DNA polymerase delta catalytic subunit
- DNA polymerase zeta catalytic subunit
- DNA polymerase delta 3, accessory subunit.
- DNA polymerase alpha catalytic subunit
- Mitotic spindle assembly checkpoint protein MAD2B
- Proliferating cell nuclear antigen
- DNA polymerase delta 4, accessory subunit
- DNA polymerase epsilon subunit
- DNA polymerase epsilon catalytic subunit
- DNA polymerase alpha subunit B
Sequence:
MFSEQAAQRAHTLLSPPSASNATFARVPVATYTNSSQPFRLGERSFNRQYAHIYATRLIQMRPFLVSRAQQHWGSQVEVKKLCELQPGEQCCVVGTLFKAMPLQPSILREISEEHNLIPQPPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVLAVFGSVKDDGKFQVEDHCFADLAPQNPVPPLDTDRFVLLVSGLGLGGGGGESLLGTQLLVDVVTGQLGDEGEQCSAAHVSRVILAGNLLSHNTQSRDSINKAKYLTKKTQAASVEAVKMLDEILLQLSASVPVDVMPGEFDPTNYTLPQQPLHPCMFPLATAYATLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMEDHLEILEWTLRVRHISPTAPDTLGCYPFYKTDPFIFAECPHVYFCGNTPSFGSKVIRGPEDQAVLLVAVPDFSSTQTACLVNLRGLTCQPISFAGFGAEQDDLEDLGLGP
Protein: Sialate O-acetylesterase (SIAE) (EC 3.1.1.53) (Sialic acid-specific 9-O-acetylesterase) (Yolk sac protein 2) [Cleaved into: Sialate O-acetylesterase small subunit; Sialate O-acetylesterase large subunit] (P70665)
Organism: Mus musculus (Mouse)
Function: Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.
Subcellular location: [Isoform 1]: Lysosome {ECO:0000269|PubMed:10464298}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:10464298}.
Interaction partners:
- N-acetylneuraminate
- B-cell receptor CD22
Sequence:
MVSPGPVFGIVLLIIARVSRSAGIGFRFASYIDNYMVLQKEPSGAVIWGFGTPGATVTVTLCQGQETIMKKVTSVKEPSNTWMVVLDPMKPGGPFEVMAQQTLGTMNFTLRVHDVLFGDVWLCSGQSNMQMTVSQIFNASKELSDTAAYQSVRIFSVSLIQSEEELDDLTEVDLSWSKPTAGNLGHGNFTYMSAVCWLFGRYLYDTLQYPIGLVSSSWGGTYIEVWSSRRTLKACGVPNTRDERVGQPEIKPMRNECNSEESSCPFRVVPSVRVTGPTRHSVLWNAMIHPLQNMTLKGVVWYQGESNADYNRDLYTCMFPELIEDWRQTFHYGSQGQTDRFFPFGFVQLSSYMLKNSSDYGFPEIRWHQTADFGHVPNPKMPNTFMAVAIDLCDRDSPFGSIHPRDKQTVAYRLHLGARAVAYGEKNLTFQGPLPKKIELLASNGLLNLTYDQEIQVQMQDNKTFEISCCSDRHCKWLPAPVNTFSTQTLILDLNACLGTVVAVRYAWTTWPCEYKQCAVYHTSSMLPAPPFIAQISHRGI
Protein: BTB/POZ domain-containing protein KCTD8 (Q50H33)
Organism: Mus musculus (Mouse)
Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
Subcellular location: Presynaptic cell membrane {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}.
Interaction partners:
- Gamma-aminobutyric acid type B receptor subunit 1
Sequence:
MALKDTGSGGSTILPISEMVSASSSPGAPLAAAPGPCAPSPFPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGGARRRGDLPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFPEKERLLREAEFFQLTDLVKLLSPKVTKQNSLNDECCQSDLEDNVSQGSSDALLLRGAAAGAPSGSGAHGVSGVVGGGSAPDKRSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFDRLSEAGFHMVACNSSGTAAFVNQYRDDKIWSSYTEYIFFRPPQKIVSPKQEHEDRKRDKVTDKGSESGTSCNELSTSSCDSHSEASTPQDNPANTQQAAAHQPNTLTLDRPSRKAPVQWMPPPDKRRNSELFQSLISKSRETNLSKKKVCEKLSVEEEMKKCIQDFKKIHIPDCFPERKRQWQSELLQKYGL
Protein: Kelch-like protein 26 (Q53HC5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAESGGSSGGAGGGGAFGAGPGPERPNSTADKNGALKCTFSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRAGTRR
Protein: Ribosomal protein uL3-like (60S ribosomal protein L3-like) (Large ribosomal subunit protein uL3-like) (Q92901)
Organism: Homo sapiens (Human)
Interaction partners:
- Large ribosomal subunit protein eL19
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein eS24
- Large ribosomal subunit protein eL15
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL8
- Small ribosomal subunit protein eS6
Sequence:
MSHRKFSAPRHGHLGFLPHKRSHRHRGKVKTWPRDDPSQPVHLTAFLGYKAGMTHTLREVHRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSFKTIFAEHLSDECRRRFYKDWHKSKKKAFTKACKRWRDTDGKKQLQKDFAAMKKYCKVIRVIVHTQMKLLPFRQKKAHIMEIQLNGGTVAEKVAWAQARLEKQVPVHSVFSQSEVIDVIAVTKGRGVKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHHRTELNKKIFRIGRGPHMEDGKLVKNNASTSYDVTAKSITPLGGFPHYGEVNNDFVMLKGCIAGTKKRVITLRKSLLVHHSRQAVENIELKFIDTTSKFGHGRFQTAQEKRAFMGPQKKHLEKETPETSGDL
Protein: Nuclear export mediator factor (A0A0G2K9F2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- E3 ubiquitin-protein ligase listerin
- Transcription factor 25
- tRNA endonuclease ANKZF1
- Protein pelota homolog
- Activating signal cointegrator 1 complex subunit 3
- Large ribosomal subunit protein uL14
- Alanine--tRNA ligase, cytoplasmic
- Threonine--tRNA ligase 1, cytoplasmic
Sequence:
MKTRFSTVDLRAVLAELNANLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKCRKHLKSRRLVSAKQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYEYLILNILRFRTDEADDVKFAVRERYPIDHARAAEPLLTLERLTEVIARAPRGELLKRVLNPLLPYGPALIEHCLIENGFSGNVKVDEKLESKDIEKILVCVQRAEDYLEKTANFNGKGYIIQKREVKPSLDANKPAEDILTYEEFHPFLFSQHLQCPYIEFESFDKVSFLEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDRAIQVVRSALANQIDWTEIGVIVKEAQAQGDPVASAIKELKLQTNHITMLLRNPYLLSEEEDGDGDGSIENSDAEAPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQRTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYLIIGGRDQQQNEIIVKRYLTPGDIYVHADLHGATSCVIKNPTGDPIPPRTLTEAGTMALCYSAAWDARVITSAWWVHHHQVSKTAPTGEYLTTGSFMIRGKKNFLPPSYLMMGFSFLFKVDESCVWRHRGERKVRVQDEDMETLTSCTSELMSEEMEQLEGGDSSEEETEELRGTTEEVELRTQADPEDIAAHSGREELSSEDGEAIKTATKDEEPIGEVREEEEEPFEYPDTTIDLSHLQSQR
Protein: Expressed sequence AW551984 (Q8BGF0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVRSGGLLTSIRDPVALKSIAVTLSINDFVAGVSATLNYENEEKSPLEAFFVFPMDEDSAVYSFEAFVDGKKIVAELQDKYQAHKRYEEALSGGYQAYLLEEDKCSRDVFCCNVGNLQPGSKVSLTLRYVQELPLEDDGALRYVLPAILNPRYHLSDGREDSNLDMKTPIVPLEELPYTLSMVATISSQLGISTIQSNCPLNPIEYTGDNKTSAQVSLAEGHKFDRDVELLIFYRKVHSPSVAVEMGMSGRPSDSLMGAPSAMVSFYPDIPEVETTTKCGEFVFLMDRSRSMNSPMSSKDKSQLRIDAAKETLILLLKSLPMGCYFNIYGFGATHEEFFPDSVMYNQETMQIAVKKVKRLLADLGGTELLTPLRKIFRKPPIPGHPLQVFVFTDGEVVETFSVIREVMFQSKKHRCFSFGIGEGASTSLIKNLARVSGGTAEFITGNDRMQSKALRSLRRSLQSVVEDVSLSWNLPPKMFAPMLSPEQTSIFRGQRLIIYSLLIGKIPKEEATGEVCLSYKLHGKSYEEKVTFSLQPKPDDNLTIHRLAAKSMIQSKDFGFKETSLMYKRDVLDISLESGVMSSFTAFVAINKELNEPIQGPLVHRDIPRPILLGAGPNRPSDGGYPKTLFCASAPVTLPPWLKGSGKCVATILMPNGTPQQRQNSQKKKCVVHTDTRPELPHLAKYDSYPQGSKEHSIAQLIYLQNADGSWDMNEDLAKILSTSLEDITAACPTEVLEPSAWATMLAVIWLHANGKELKDEWELLERKAVVWLHNNSVRGFNKLIRTANKLLKTSLSPSIFKL
Protein: FAD-dependent oxidoreductase domain-containing protein 1 (Q38A60)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGSFTSCDQRPTASTTAAPHSYDADKVLRNFDTSTPTAAVIGAGITGVHIAYELAQLGFRVTVFEQRRDIGLGETQYALPFVGVGLLHPYIHSIRMGRELLWSKLKLNSKDIVTVDFSWNFLFSSFIHRWLWARKWGKLRAEEVMKYTNNLARLSVGVIDELSHKHKTLAPYVLSRNVTVQTLEEGPRADKREAILHQAATAHRQPLMVDLVGWTRELAKVCREKYGVEFAVGEKLLDFKTTLSFGVEVVSGLRFSRNVDGRVEYKNRVFDVVVLAAGAQTGELTWESSQIPIVGLAGCSVALRPGAGEGVGELMGKLHLSSPGLVMVSPESHLVCYRTSASNDAGGEVLFLQGLLSLDCTVRTLPRVGRMLSRIEAHLREKCQINIPLLHRYRECGGRQQLDDGNTHVVTSNPVMHAAEYIRSSTPDGVPFIGDNGAAFNSFICAGFGDHAADMAPGAAKILAKFIELKACAMQRQDEKTMERDGYNIAAVMSDERVEKTRRELQLLLNGCQTIDDIPPGGELENFVQLPYSYTRFDGVVKDQIPDVAHVSLLQRVSDMEKRLLQTFAPWEHYINQQAIKLSRRDNVPDWLRTIVYYYFLDESDDLEMLKNKQKYVEGIRRIREQFEEGNETSASGATPSSSS
Protein: Probable ATP-binding protein YbiT (P0A9U3)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Acetate CoA-transferase YdiF
Sequence:
MLVSSNVTMQFGSKPLFENISVKFGGGNRYGLIGANGSGKSTFMKILGGDLEPTLGNVSLDPNERIGKLRQDQFAFEEFTVLDTVIMGHKELWEVKQERDRIYALPEMSEEDGYKVADLEVKYGEMDGYSAEARAGELLLGVGIPVEQHYGPMSEVAPGWKLRVLLAQALFADPDILLLDEPTNNLDIDTIRWLEQVLNERDSTMIIISHDRHFLNMVCTHMADLDYGELRVYPGNYDEYMTAATQARERLLADNAKKKAQIAELQSFVSRFSANASKSRQATSRARQIDKIKLEEVKASSRQNPFIRFEQDKKLFRNALEVEGLTKGFDNGPLFKNLNLLLEVGEKLAVLGTNGVGKSTLLKTLVGDLQPDSGTVKWSENARIGYYAQDHEYEFENDLTVFEWMSQWKQEGDDEQAVRSILGRLLFSQDDIKKPAKVLSGGEKGRMLFGKLMMQKPNILIMDEPTNHLDMESIESLNMALELYQGTLIFVSHDREFVSSLATRILEITPERVIDFSGNYEDYLRSKGIE