wanglab/gogpt-training-data huggingface dataset:
Protein: Mannan polymerase II complex anp1 subunit (M-Pol II subunit anp1) (O74745)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P32629}. Golgi apparatus membrane {ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P32629}. Note=Cis-Golgi (PubMed:18184749). Recycles between endoplasmic reticulum and Golgi (By similarity). {ECO:0000250|UniProtKB:P32629, ECO:0000269|PubMed:18184749}.
Interaction partners:
- Uncharacterized alpha-1,2-galactosyltransferase C637.06
- Mannan polymerase complex subunit mnn9
- Uncharacterized alpha-1,2-galactosyltransferase C8D2.17
- Alpha-1,2-galactosyltransferase
- Initiation-specific alpha-1,6-mannosyltransferase
- Inositol phosphoceramide mannosyltransferase 2
- DSC E3 ubiquitin ligase complex subunit 3
- Protein transport protein sec24
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Dolichol-phosphate mannosyltransferase subunit 3
Sequence:
MKANRDFGRDGGPFSITPNRFQPKSSGNPIFRQKTIRTVGIIALTLVLFLFFHRSFFSSFGEFPSFSSTANAPNSDVQEYDLRKVMNAKFTGDYSPKEKVLICAPLRNAAEHLNMFFGHMNNLTYPHELIDLAFLISDTDDNTLEVLKQHLDAIQNDEDESKHFNNVLIMLKDFGAIFGQEFSDRHGFAAQGPRRKLMARARNWLLSAAIQPYHSWVYWRDVDVETAPNTILEDLMRHDKDIIVPNVYRPLPDWLGNEQPYDLNSWAESETALQLADTLGEDDVIVEGYAEYATWRPHLAYLRDPNGDPSVEMPLDGIGGVSIMSKAKVHLEGCEFPAFSFEKHAETEGFGKMAKRMGFSVYGLPHYVIWHIYEPSDDDKRIMAEMERERKEREAAELEEAKKYQTAGFTQPDDQGAEEGPLAHADDHVD
Protein: C-type lectin domain family 4 member E (C-type lectin superfamily member 9) (Macrophage-inducible C-type lectin) (Mincle) (Q9R0Q8)
Organism: Mus musculus (Mouse)
Function: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 (Th1) and T-helper 17 (Th17) cell subtypes. Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18490740, ECO:0000305|PubMed:10528209, ECO:0000305|PubMed:23602766}; Single-pass type II membrane protein {ECO:0000305|PubMed:10528209}. Cell projection, phagocytic cup {ECO:0000269|PubMed:18490740}.
Interaction partners:
- High affinity immunoglobulin epsilon receptor subunit gamma
- Tyrosine-protein kinase SYK
- C-type lectin domain family 4 member D
- Splicing factor 3B subunit 3
- TYRO protein tyrosine kinase-binding protein
- Caspase recruitment domain-containing protein 9
- Toll-like receptor 2
- Cis-aconitate decarboxylase
- C-type lectin domain family 9 member A
- C-type lectin domain family 6 member A
Sequence:
MNSTKSPASHHTERGCFKNSQVLSWTIAGASILFLSGCFITRCVVTYRSSQISGQNLQPHRNIKELSCYSEASGSVKNCCPLNWKHYQSSCYFFSTTTLTWSSSLKNCSDMGAHLVVIDTQEEQEFLFRTKPKRKEFYIGLTDQVVEGQWQWVDDTPFTESLSFWDAGEPNNIVLVEDCATIRDSSNSRKNWNDIPCFYSMPWICEMPEISPLD
Protein: Chromosome transmission fidelity 4 (LD47422p) (Q494K2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA replication licensing factor Mcm6
- DNA polymerase alpha catalytic subunit
- DNA replication complex GINS protein SLD5
- DNA replication licensing factor Mcm3
- CDC45L
- DNA polymerase epsilon catalytic subunit 1
- DNA replication licensing factor MCM4
- Protein MCM10 homolog
- DNA replication licensing factor Mcm5
- DNA replication licensing factor Mcm2
Sequence:
MSFLRSALRYAHTNGYTGLLYTPRGEFIITCGTDGDIRHWTCISDDDPRSSCLGEFVMCIAHTGTRLLASTDRNTIHAYTFPEMDSDGILMRFTAPATCLKVSGGYTAAGSEDTTIKVLKGDTAGNETVLEGHTGPILALDLFAERKLLVSVAGDGQLKVWNFEEGKELKTIGGLPKVNSFESASLYGTPHFEPQSGELLAYAVDNEIVVLNTANWEVAFKLRDDSVSSNYSCCQFSPNGERLAAGTTKGEVSIFDVKKRKAVTVEIPPSDCNAITCLAWNLSGEVEVAFCDATGQLGTVFLGDAVDTGNGDGLVDDQAELLGDDYEFEAGDDVDTAADDGDGVSLEQLKRKVMNFADPVDHDDASNQSLDSSSRTVPAPVAPQIKLFKQQTAFQPSATPADLEHRYMAWNDVGIVTAHVEPSGDSSIDVEFHDASIHHALHISNYNQHNLASVSSGALALASNESSKLVVIALAAAGNKEWSLSLPDCESAEAVVATRFLVAVATSSSFLRIFTVMGTQREVLTIPGPMVAIAGHEHSLMVVYHSSAPSQTQQHLAAMLVNINGLSLRQEYLPVPLTPGRQLTWFGYSDTGSPSIADNMGLLQLYRRSSNAWFPICDTMKQSTSVSHNFFVVAVSEKRQIVQAVLCRGTSYPMTNPRPMLQELRMQIPLCDVEVEKSELEDALLRSSLMQMDGAEKMQKETAIKLFALACSSECETRARELIESIACTDLLQLAVKYATKRGRIHLSDRLCELLPQLEAVQEARKQQTLLGASGIAATIVLPMTPTSASQSGPKPKAIELSSAKRGTLKRLVNSPNMFKAAAASAASRPSTPDITPSPLDTQENIFGESESEVPMGKATDHRSPLNSVNPFAMKRKLGDTGVIFGSEKLKLAKK
Protein: Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (rATA1) (Glutamine transporter) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System A transporter 2) (System N amino acid transporter 1) (Q9JM15)
Organism: Rattus norvegicus (Rat)
Function: Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient. Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis. May also contributes to amino acid transport in placental trophoblast (By similarity). Regulates synaptic plasticity (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10660562, ECO:0000269|PubMed:12684517, ECO:0000269|PubMed:15054072}; Multi-pass membrane protein {ECO:0000305|PubMed:10660562}. Note=Restricted to the somatodendritic compartment of neurons (Probable). Found in the cellular processes of neurons in the developing brain. {ECO:0000305|PubMed:12684517}.
Interaction partners:
- Sodium-coupled neutral amino acid symporter 2
- Neutral amino acid transporter B
- Amino acid transporter
- Large neutral amino acids transporter small subunit 1
Sequence:
MMHFKSGLELTELQNMTVPEDDNVSNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKRKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLILLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTGAMLSYLFIVKNELPSAIKSLMGEEETFSAWYVDGRVLVVMVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCMNGEQNSTVSANVTDACTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYEKVQSDLLHKYQSTGDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFHLCRHVLVTIILLVIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITNQDGDKNTQRIWAALFLALGVLFSLISIPLVIYDWACSSSNGEGH
Protein: Glycine receptor subunit beta (Glycine receptor 58 kDa subunit) (P20781)
Organism: Rattus norvegicus (Rat)
Function: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (By similarity).
Subcellular location: Postsynaptic cell membrane {ECO:0000305|PubMed:22592841}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cell membrane {ECO:0000269|PubMed:14551753, ECO:0000269|PubMed:15574743, ECO:0000269|PubMed:22592841, ECO:0000269|PubMed:8581315}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000269|PubMed:22592841}. Perikaryon {ECO:0000269|PubMed:22592841}. Cell projection, dendrite {ECO:0000269|PubMed:22592841}. Cytoplasm {ECO:0000269|PubMed:8581315}. Note=Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane. Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. {ECO:0000269|PubMed:8581315}.
Interaction partners:
- Gephyrin
- Glycine receptor subunit alpha-1
- Glycine receptor subunit alpha-2
- Glycine receptor subunit alpha-3
- Glycine--tRNA ligase
- Sodium- and chloride-dependent glycine transporter 2
Sequence:
MKFSLAVSFFILMSLLFEDACSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPPNSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNAAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKPQAKNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL
Protein: 2-hydroxyisoflavanone synthase (EC 1.14.14.87) (Cytochrome P450 93C1v2) (Isoflavone synthase 2) (Q9SWR5)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Involved in isoflavonoid biosynthesis. Converts liquiritigenin to 2-hydroxyisoflavanone which spontaneously dehydrates to daidzein.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- 2-hydroxyisoflavanone dehydratase
- Chalcone--flavanone isomerase 1A
- Isoflavone 4'-O-methyltransferase
- Isoflavone synthase
- Naringenin,2-oxoglutarate 3-dioxygenase
- Cytochrome P450 71D9
- Cytochrome P450 93B16
- Flavone synthase II
- Naringenin,2-oxoglutarate 3-dioxygenase
- Chalcone--flavanone isomerase 1B-1
Sequence:
MLLELALGLLVLALFLHLRPTPTAKSKALRHLPNPPSPKPRLPFIGHLHLLKDKLLHYALIDLSKKHGPLFSLYFGSMPTVVASTPELFKLFLQTHEATSFNTRFQTSAIRRLTYDSSVAMVPFGPYWKFVRKLIMNDLLNATTVNKLRPLRTQQIRKFLRVMAQGAEAQKPLDLTEELLKWTNSTISMMMLGEAEEIRDIAREVLKIFGEYSLTDFIWPLKHLKVGKYEKRIDDILNKFDPVVERVIKKRREIVRRRKNGEVVEGEVSGVFLDTLLEFAEDETMEIKITKDHIKGLVVDFFSAGTDSTAVATEWALAELINNPKVLEKAREEVYSVVGKDRLVDEVDTQNLPYIRAIVKETFRMHPPLPVVKRKCTEECEINGYVIPEGALILFNVWQVGRDPKYWDRPSEFRPERFLETGAEGEAGPLDLRGQHFQLLPFGSGRRMCPGVNLATSGMATLLASLIQCFDLQVLGPQGQILKGGDAKVSMEERAGLTVPRAHSLVCVPLARIGVASKLLS
Protein: Basement membrane proteoglycan (H9G353)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKRSSTVLAALLALLLVATNDAARHRKYRQTYQDIDSDDDDTSDVQITVFPSEKEVRDGRDVSFECRARTSDNSVYPTVRWARVGGPLPSSAHDSGGRLTINPVQLSDAGTYICVSDYNGNTVEARATLSVVSYGPQEVSNGLRQAGQCMADEKACGNNECVKNDYVCDGEPDCRDRSDEANCPAISRTCEPNEFKCNNNKCVQKMWLCDGDDDCGDNSDELNCNAKPSSSDCKPTEFQCHDRRQCVPSSFHCDGTNDCHDGSDEVGCVQPTVVDPPQTNLQVPRGTTFSLTCKAVAVPEPYINWRLNWGPVCEPPRCLQTSEGGYGTLTIHDAQPVDQGAYTCEAINVKGRVLATPDCIVRVVDDPRPQPPQPPTAPPQRASCDTRGAVTPYPNNYGTCECKSQVTGPNCDQCKPGAFHLSEKSPEGCLKCFCFGVSNDCRSSGHYRTKDRLMFAGDAEGVTISDIEERTIDRNTPFSFFKTGYLTFDGTTDGVAKYWRLPQRFLGDKVTAYGGKMEFEIEFSGSGHHSSEPMVVLKGNQNILVHRVRNQEHVLRSDSPVRITVETYETNYEQLNGAAATREDLLMVLADLDAFLIRATHVAHQTSTSLGDVSWEIAVDRYTPDGLALEVEQCVCPPGYLGTSCEDCAPGYERSGYGPYLGTCVPIQPRHQQCGPGAVAPTAPAQGQCQCKASVIGPNCDRCAPNSFGLAPTNPQGCIPCFCSGVTQQCSASSYRRTSVSIDYARGDRDQLELTTSDSRQPYSPQTRAELSGQAIEFRSFEEARGQTLYWKLPEKFLGDKVTSYGGTLEYTFKFSGNGNSDQSADVILRGNDIALQYKHREPFYADRENKVQIKIIETSWQRVDGQQATREHLLMTLADLDTLLIKSTYNDDCTDSQLLSANLEFAEPYGQGLTAAEVEQCICPPGYVGTSCEDCAPGYSRTGGGLYLGLCEKCECNGHASQCDKEYGYCLDCQHNTEGDQCERCKPGFVGDARRGTPNDCQPEATRAPCHCNNHSPRGCDSFGRCLLCEHNTEGTHCERCKKGYYGDATKGSPYDCTPCPCPGASDCYLDNEGQVACRICPAGLQGRLCNECAPGYTRSNKPAGRVCEPIGQVTNEDITFVQKPHEVLRVRIMEPKRQIALPGDRVHWICQVTGYTTEKIHVEWTKVGEMSLPPNAKAYDGYLVLKGVEAENAGQYRCTATTITQYATDDALLTISKRISGRPPQPVIDPPHLVVNEGEPAAFRCWVPGIPDCQITWHREQLGGPLPHGVYQTGNALKIPQSQLHHAGRYICSAANQYGTGQSPPAVLEVKKPVIPPKVDPIRQTVDRDQPARFKCWVPGNSNVQLRWSRPGGAPLPSGVQEQQGILHIPRASDQEVGQYVCTATDPSDNTPLQSEPVQLNIRDPAPPQRGAAPQIDPPNQTVNVNDPAQFRCWVPGQPRAQLKWSRKDGRPLPNGILERDGFLRIDKSQLHDAGEYECTSTEPDGSTQLSPPARLNVNQPQAIQPQVDPPVQTVNEGEPSRIRCWVPGHPNIQLQFVKRGRRPLPAHARFSQGNLEIPRTLKSDEDEYICIATDPTTNRPVESNPARVIVKSHQEPPTAVVEPRTWNGKPGERHQFRCITTGSPTPKITWTGPNGSPLPHDVTPLEPNILDFSNGRSELNGDYTCTASNPIGEASDHGNVNIGPSLTVKTNPPGPKLIVTVGEPLQVKCEAFGAPGDPEPEVEWLHDPGPERGDLPDDFKPVTISEQFIRHPNVGLGNAGVYTCKGSSAHATATKNIYIEVVEPSRIATVSILGGSSQWFDQGEKGELICTATGSSLVDRLEWEKVDDQLPTDVEEHNEPGLLHFPSFKNSYAGEYRCNGYRNNEIIASAAVHVHSSANADDEPKVEIEPPRVRVVSQGDNIVLKCSVQGAENGEHFKWALLRGGSLVRQLGTEPTLEITKADPSNDFGVYRCNVEDNNGLVIGSAFTAVSVGQQDKSHAQIVKFDDKSDASFTCPIYSVPGSKVDWTYENGDLPSKAVPNGNKIEIKEFDDASAGTYVCKVSFDGNVVEGFVTAQMFVPDTIIQVLLEVSSESPQIGDRAWFDCKVTGDPSAVISWTKEGNDDLPPNAQVTGGRLLFTDLKEDNAGVYRCVAKTKAGPLQTRTVLNVGSGKRKRKHLGNRRGRRLRHRRRNAQNGPLSRKTRTTTKLFGSWF
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (H3BVD1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
Sequence:
MELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
Protein: EI24 autophagy associated transmembrane protein (cDNA, FLJ79438, highly similar to Etoposide-induced protein 2.4) (B7ZB74)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYCFEYRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIISANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSTSAEKFPSPHPSPAKLKATAGH
Protein: Caffeic acid 3-O-methyltransferase (CAOMT) (COMT) (EC 2.1.1.68) (S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase) (P28002)
Organism: Medicago sativa (Alfalfa)
Function: Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid (Probable). The resulting products may subsequently be converted to the corresponding alcohols that are incorporated into lignins (Probable).
Interaction partners:
Sequence:
MGSTGETQITPTHISDEEANLFAMQLASASVLPMILKSALELDLLEIIAKAGPGAQISPIEIASQLPTTNPDAPVMLDRMLRLLACYIILTCSVRTQQDGKVQRLYGLATVAKYLVKNEDGVSISALNLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNKGMSDHSTITMKKILETYTGFEGLKSLVDVGGGTGAVINTIVSKYPTIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSIPKADAVFMKWICHDWSDEHCLKFLKNCYEALPDNGKVIVAECILPVAPDSSLATKGVVHIDVIMLAHNPGGKERTQKEFEDLAKGAGFQGFKVHCNAFNTYIMEFLKKV
Protein: NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (HIRA-interacting protein 5) (Q9UMS0)
Organism: Homo sapiens (Human)
Function: Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins.
Subcellular location: Mitochondrion. Cytoplasm, cytosol.
Interaction partners:
- Cysteine desulfurase
- Iron-sulfur cluster assembly enzyme ISCU
- Iron-sulfur cluster assembly 1 homolog, mitochondrial
- Iron-sulfur cluster assembly 2 homolog, mitochondrial
- BolA-like protein 3
- Selenocysteine lyase
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Laforin
- Iron-sulfur cluster assembly factor IBA57, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
Sequence:
MAATARRGWGAAAVAAGLRRRFCHMLKNPYTIKKQPLHQFVQRPLFPLPAAFYHPVRYMFIQTQDTPNPNSLKFIPGKPVLETRTMDFPTPAAAFRSPLARQLFRIEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASGLPLVTEETPSGEAGSEEDDEVVAMIKELLDTRIRPTVQEDGGDVIYKGFEDGIVQLKLQGSCTSCPSSIITLKNGIQNMLQFYIPEVEGVEQVMDDESDEKEANSP
Protein: Ferritin light chain 1 (Ferritin L subunit 1) (P02793)
Organism: Rattus norvegicus (Rat)
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Subcellular location: Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:P02792}. Cytoplasm {ECO:0000250|UniProtKB:P29391}. Autolysosome {ECO:0000250|UniProtKB:P29391}.
Interaction partners:
- Ferritin heavy chain
- Nuclear receptor coactivator 4
- Transferrin receptor protein 1
- Ferroportin
- Iron-responsive element-binding protein 2
- Natural resistance-associated macrophage protein 2
- Cytoplasmic aconitate hydratase
Sequence:
MTSQIRQNYSTEVEAAVNRLVNLHLRASYTYLSLGFFFDRDDVALEGVGHFFRELAEEKREGAERLLKLQNERGGRALFQDVQKPSQDEWGKTLEAMEAALALEKNLNQALLDLHALGSARTDPHLCDFLESHFLDKEVKLIKKMGNHLTNLRRVAGPQPAQTGVAQASLGEYLFERLTLKHD
Protein: Uncharacterized WD repeat-containing protein C13G6.08 (Q09786)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Anaphase-promoting complex subunit 4
- G2/mitotic-specific cyclin cdc13
- Mitotic spindle checkpoint component mad2
- Anaphase-promoting complex subunit 3
- Anaphase-promoting complex subunit 14
- Anaphase-promoting complex subunit cut9
- Anaphase-promoting complex subunit 8
- Serine/threonine-protein kinase plo1
- Ubiquitin-conjugating enzyme E2-20 kDa
- Anaphase-promoting complex subunit 1
Sequence:
MSTLYQVNKIKEILIRFLETIIINGMNSFSSTVYGQNAERSNTPTLIDPSNKETANVCPISKNLFQSYPKGSYRNSQRLTSRNGLDRFIPMTSNKDTISLGRHSSLSRNLVNKTKNASETYQQLLEYALEVERDDNVFTYAKLQKSDMTQKCPTMVASEKDNKGKLNEKKNRSPENLLPFRILDAPELRDDFYTSLLSWSPKGDLAIGLAENIYLWSKELGPTRVLEESIYDVSSVAYSYNGDILAVGRVDGTLQFWQDNERVPRISIHHPGDIGVLAWKPVLETNRLLVGKGNGNIFVYDIIWSESTSKAVLVATITNAHDEQVCGLTWNHDGSQFASGGNDNRVCLFKGSDLRQPLYVWQQNAAVKALSFCPWQRSLLATGAGSHDKHIRFYNCFNGKKIDELYCGAQITSIHWSPKYREFSVTFGYSLETVQHRFAVYSWPQLECLVSVLPSVPDIRCVHSVLTSQLNETTGRCEMTDSIIIASSNETIKFFDLSEESSWHNSRVLTWHGIFDSQILEMLEGIDGKIDSHLR
Protein: diphthine methyl ester synthase (EC 2.1.1.314) (Q583F0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Elongation factor 2
- U5 small nuclear ribonucleoprotein component, putative
- Elongation factor 2
- Elongation factor G, mitochondrial
Sequence:
MFTLIGLGLGDANDITVNGLKAVHDADVVYLEAYTSFLINSSPEELSAAYGKPVIVADREMVESGDVLRDAESKKVAFLVVGDVFGATTHSDLVVRCREQKIECRAIHNASIINAVGCCGLQLYRFGQVLSLCFWTETWKPDSWYDRLKTNRDAGLHTLVLLDIKVKEISDENLARGRKVYEPPRYMKISEAIDQILAVEKRKGRGAVAVDGGTLAVGMARVGSATQQVVAGPMQALRAVDFGTPLHSLVIAGEVHPCEEEHLRLFYLN
Protein: Jerky protein homolog-like (Human homolog of mouse jerky gene protein) (HHMJG) (Q9Y4A0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583}.
Interaction partners:
Sequence:
MSGKRKRVVLTIKDKLDIIKKLEDGGSSKQLAVIYGIGETTVRDIRKNKEKIITYASSSDSTSLLAKRKSMKPSMYEELDRAMLEWFNQQRAKGNPISGPICAKRAEFFFYALGMDGDFNPSAGWLTRFKQRHSIREINIRNERLNGDETAVEDFCNNFRDFIERENLQPEQIYNADETGLFWKCLPSRISVIKGKCTVPGHKSIEERVTIMCCANATGLHKLKLCVVGKAKKPRSFKSTDTLNLPVSYFSQKGAWMDLSIFRQWFDKIFVPQVREYLRSKGLQEKAVLLLDNSPTHPNENVLRSDDGQIFAKYLPPNVASLIQPSDQGVIATMKRNYRAGLLQNNLEEGNDLKSFWKKLTLLDALYEIAMAWNLVKPVTISRAWKKILPMVEEKESLDFDVEDISVATVAAILQHTKGLENVTTENLEKWLEVDSTEPGYEVLTDSEIIRRAQGQADESSENEEEEIELIPEKHINHAAALQWTENLLDYLEQQGDMILPDRLVIRKLRATIRNKQKMTKSSQ
Protein: Autophagy-related protein 19 (Cytoplasm-to-vacuole targeting protein 19) (P35193)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Also plays a role in regulation of filamentous growth.
Subcellular location: Preautophagosomal structure membrane {ECO:0000269|PubMed:11382752, ECO:0000269|PubMed:11430817, ECO:0000269|PubMed:11675395, ECO:0000269|PubMed:12446664, ECO:0000269|PubMed:12479808, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15194695, ECO:0000269|PubMed:15659643, ECO:0000269|PubMed:17192412, ECO:0000269|PubMed:18497569, ECO:0000269|PubMed:21343297}; Peripheral membrane protein {ECO:0000269|PubMed:11382752, ECO:0000269|PubMed:11430817, ECO:0000269|PubMed:11675395, ECO:0000269|PubMed:12446664, ECO:0000269|PubMed:12479808, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15194695, ECO:0000269|PubMed:15659643, ECO:0000269|PubMed:17192412, ECO:0000269|PubMed:18497569, ECO:0000269|PubMed:21343297}. Note=Also found in other perivacuolar punctate structures.
Interaction partners:
- Alpha-mannosidase
- Autophagy-related protein 11
- Vacuolar aminopeptidase 1
- Autophagy-related protein 8
- Aspartyl aminopeptidase 4
- Autophagy-related protein 34
- Serine/threonine-protein kinase ATG1
- Ubiquitin carboxyl-terminal hydrolase 3
- Autophagy-related protein 32
- Ubiquitin-like protein ATG12
Sequence:
MNNSKTNQQMNTSMGYPLTVYDECNKFQLIVPTLDANIMLWCIGQLSLLNDSNGCKHLFWQPNDKSNVRILLNNYDYGHLFKYLQCQRKCSVYIGEGTLKKYNLTISTSFDNFLDLTPSEEKESLCREDAHEDPVSPKAGSEEEISPNSTSNVVVSRECLDNFMKQLLKLEESLNKLELEQKVTNKEPNHRISGTIDIPEDRSELVNFFTELKTVKQLEDVFQRYHDYERLSQECDSKTEIASDHSKKETKIEVEPPNERSLQITMNQRDNSLYFQLFNNTNSVLAGNCKLKFTDAGDKPTTQIIDMGPHEIGIKEYKEYRYFPYALDLEAGSTIEIENQYGEVIFLGKYGSSPMINLRPPSRLSAESLQASQEPFYSFQIDTLPELDDSSIISTSISLSYDGDDNEKALTWEEL
Protein: Syncytin-1 (Endogenous retrovirus group W member 1) (Env-W) (Envelope polyprotein gPr73) (Enverin) (HERV-7q Envelope protein) (HERV-W envelope protein) (HERV-W_7q21.2 provirus ancestral Env polyprotein) (Syncytin) [Cleaved into: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)] (Q9UQF0)
Organism: Homo sapiens (Human)
Function: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5.
Subcellular location: [Surface protein]: Cell membrane {ECO:0000305|PubMed:15827173}; Peripheral membrane protein {ECO:0000305|PubMed:15827173}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000305|PubMed:15827173}.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Syncytin-1]: Virion {ECO:0000250}.
Interaction partners:
- C-C chemokine receptor type 5
- T-cell surface glycoprotein CD4
- Angiotensin-converting enzyme 2
- C-X-C chemokine receptor type 4
- Inter-alpha-trypsin inhibitor heavy chain H4
- Neutral amino acid transporter B
- Toll-like receptor 4
- Neutral amino acid transporter A
- Plasminogen
- CD209 antigen
Sequence:
MALPYHIFLFTVLLPSFTLTAPPPCRCMTSSSPYQEFLWRMQRPGNIDAPSYRSLSKGTPTFTAHTHMPRNCYHSATLCMHANTHYWTGKMINPSCPGGLGVTVCWTYFTQTGMSDGGGVQDQAREKHVKEVISQLTRVHGTSSPYKGLDLSKLHETLRTHTRLVSLFNTTLTGLHEVSAQNPTNCWICLPLNFRPYVSIPVPEQWNNFSTEINTTSVLVGPLVSNLEITHTSNLTCVKFSNTTYTTNSQCIRWVTPPTQIVCLPSGIFFVCGTSAYRCLNGSSESMCFLSFLVPPMTIYTEQDLYSYVISKPRNKRVPILPFVIGAGVLGALGTGIGGITTSTQFYYKLSQELNGDMERVADSLVTLQDQLNSLAAVVLQNRRALDLLTAERGGTCLFLGEECCYYVNQSGIVTEKVKEIRDRIQRRAEELRNTGPWGLLSQWMPWILPFLGPLAAIILLLLFGPCIFNLLVNFVSSRIEAVKLQMEPKMQSKTKIYRRPLDRPASPRSDVNDIKGTPPEEISAAQPLLRPNSAGSS