wanglab/gogpt-training-data huggingface dataset:
Protein: Immunoglobulin superfamily member 10 (IgSF10) (Q3V1M1)
Organism: Mus musculus (Mouse)
Function: Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q6WRI0}.
Interaction partners:
Sequence:
MQKRGREVSCLLISLTAICLVVTPGSRVCPRRCACYVPTEVHCTFRYLTSIPDGIPANVERVNLGYNSLTRLTENDFSGLSRLELLMLHSNGIHRVSDKTFSGLQSLQVLKMSYNKVQIIEKDTLYGLRSLTRLHLDHNNIEFINPEAFYGLTLLRLVHLEGNRLTKLHPDTFVSLSYLQIFKTSFIKYLYLSDNFLTSLPKEMVSSMPNLESLYLHGNPWTCDCHLKWLSEWMQGNPDIIKCKKERIPSSPQQCPLCMNPRISKGRSIAMVPSGSFLCTKPTIDPSLKSKSLGIQEDNGSASVSPQDFIEPFGSLSLNMTDLSGNKANVICSIQKPSRTLPIAFTEENDYIMLNMSFSTNLVCSVNYNHIQPVWQLLALYSDSPLILERKPQHTETPLLSPKYQQVALRPEDTFTNIEADFKADPFWFQQEKISLQLNRTATTLSTLQIQFSTDAQITLPKAEMRPVKRKWTMILMMNNTRLEHTVLVGGTIALDCPGKGDPSPHLEWVLADGSKVRAPYVSEDGRILIDKKGKLELQMADTFDAGLYHCISTNDADADILTYRITVVEPYVENKHENGALHTVIMGEILDLPCLSTGIPDASISWILPRNTVFSQSSRDMQILNNGTLRILQATPKDQGHYRCVAANPSGADFSSFQVSVQMKGQRTIEHDRDIDGSGLEEPKPSVLLKQPPSLKLPASSLTGTEAGKQVSGIHKKNKHRDLTHRRRGDSTLRRFREHRRQLPLSARRIDPQHWAALLEKAKKNSVLRKQENTTVKPTPLAIPLVELAGEEKDASGLTPPDEEFTVLKTKAFGVPERSPTADSRPVNHGFVTSSASGTEVSSTVNPQTLLPTHLPDFKLFNVVDSAAVSKSMNRPVTSKIEDTTHQNPIIIFPSVAEIQDSAQVGRTSSQSAHPATGGAMATYGYTTMLSSFTNKANTVLQSANPTESYGPQIPLTEVSRVSSNNSLAHTTKDPGFSKRPSDSHTTAPSLFQTPRNNSTGNVGRERTIWSRGRAISPYRTPVLRRHRHRIVRPALKGPANRNISQVSATEPPGMCRTCSSTERLTMATAALSVTGSSHTTLPKANNVGIISEESTTVVKKPSLLLKNKQDVDIETITTTINYFRSESTHMTPTEASMISAPTSISLGKTPIDTSGHLSMPRTIQAGTDLVVTPPLSSPLSQPSIPTKATSTKLSRRKIPWHPIFANNHNKEGMLKNLHQFGLQKNTATKPPEKAPLLPTDHGSSSPSTTLLASLTPAQSATMAATRRNGTEVQGARSLSAGKEQPFINSFLVLPSTTRKRSSTLSFLSVETPTVTTPPVIASAIISETQEVRSKKAKDQTKGSLKNRKGPTITPRQISGYSTYSVPTTTDTPLAFSHSPGKVTGRTVSTAAPHSAASLLGITELPQKCTHTSGNITASETTLLSKSQESTAMKRASATPPLLSSGAPRMPTPSPPPFTKVVVTDSEVPAVFKMMSNRMVTIYESSRHDIDLQQPSAEASPNPEILTGSTDFPLSSLLTSTPMPAPRVDKPQDSQWKPSPWPENKFQLRSYSETIEKGKRPEISLSPHLSFPEASTHALHWNAQRHAEKSVFDKKPAQNPTSKHLPYDSLPKTILKKPRIIGGKAASFTVPTNSDVLLPCEAVGDPKPTIHWTRVSSGREISRGIQKTRFHVLPNGTLSIQRVSIQDRGQYLCAASNPLGVDHLHVTLSVVSYPARILESHVKEITAHSGSTVKLKCRVEGMPRPTISWILANQTVVSETPEGSRKVWVTPDGTLIIHNLSLYDRGFYKCVANNPSGQDSLLVKIQVITAPPVIIEQKRQAIVGVLGESLKLPCTAKGTPQPSVHWVLYDGTELKPLQLTHSRFFLYPNGTLYIRNIVSSVRGTYECIATSSSGSERRVVILRVEEQETVPRIETASQKWTEVNLGEKLLLNCSATGDPKPTIIWKLPSKVVIDQWHRMGSRIHVYPNGSLVIGSVTEKDGGDYLCVARNKMGDDLVLMHVRLRLTPAKIEHKQHFKKQVLHGKDFQVDCKASGSPVPEVSWSLPDGTVVNNVAQADDSGYRTKRYTLFHNGTLYFNKVGMAEEGDYICSAQNTLGKDEMKVHLTVLTAIPRIRQNYRSNVRIKAGDTAVLDCEVTGEPKPNVFWLLPSNNVISFSNDRFIFHANGTLSINKVKPLDSGKYVCVAQNPSGDDTKTYKLDIVSRPPLINGLYANKTVIKATAIQHSKKHLDCRADGVPPPQITWIMPDNIFLTAPYYGGRITVHQNGTLEIRNIRLSDSADFTCVVRSEGGESVLVVQLKVLEMLRRPTFRNPFNEKVVAQVGKPVAMNCSVDGNPTPEIIWILPDGTQFANGPQNSPYLMASNGSLIVYKATRNKSGKYRCTARNKVGYIEKLILLEIGQKPVILTYEPGMIKSAGGESLSLHCVSDGIPKPNVKWTTPGGLVIDRPQVGGKYILHENGTLVIKETTAHDRGNYICKAQNSVGQAVISVPVTIVAYPPRIINYLPRSMLRRTGEAMQLHCVALGVPKPQITWETPGYSLLSTATERRPHRSEMLPLQGTLVIQNLRASDSGVYKCRAQNVLGADYATTYIQVL
Protein: Respiratory transcription factor ZNF1 (Zinc finger protein 1) (P43551)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor that regulates respiratory growth and plays a critical role in stress adaptation during non-fermentative growth. Binds to promoters of genes involved in non-fermentative metabolism, including processes such as gluconeogenesis (PCK1, FBP1 and MDH2), glyoxylate shunt (MLS1 and ICL1) and the tricarboxylic acid cycle (ACO1). Plays a role in maintaining mitochondrial morphology and function. Also plays a role in tolerance to pH and osmotic stress, especially during the oxidative metabolism.
Subcellular location: Nucleus {ECO:0000305|PubMed:25673751}.
Interaction partners:
- Alpha-agglutinin
Sequence:
MARNRQACDCCCIRRVKCDRKKPCKCCLQHNLQCTYLRPLKKRGPKPVKVRNLKKVDDVQVFSKSSSGGIMKVPKALIDQCLRLYNDKLYVIWPLLCYDDLYELLEKRYDETCVYWFLVSLSAATLSDLQTEIESEGGVTFTGIQLSSFCMSSRQEFDDFNGSDIFKIMTYYCLNRCYAQMSNSRTSYRLSCEAVGLIKLAGFHREETLKLLPFDEQQLGRKVYYLLLLTERYFSVYTHCATSLDTTIAPPQPENVTDPRLSLDSFLEMIRVFTVPGKCFFDALATDSANVTCTEDSLKKIWRELHTVPLEIEPWSYGYVDISFSRHWIRTLAWKLVLQISGMRISFLSNSKNTHIPVEIARDMLEDTFLIPKNLYAVHGPGISVKALEIADALVDVVNQYDQNAESEAWNFLFDISKFVFSLKHCDSTLVDKFTTKCQCALITLPLSNPLESTDGSKEDVDALP
Protein: Major facilitator superfamily domain-containing protein 12 (A0A3Q2HW92)
Organism: Equus caballus (Horse)
Function: Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin/hair pigmentation. In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin/hair pigmentation. Also catalyzes import of cysteine into lysosomes in non-pigmented cells.
Subcellular location: Melanosome membrane {ECO:0000250|UniProtKB:Q6NUT3}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q6NUT3}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MVPGSPAAGAGPAPRALSLAARLSYAVGHFLNDLCASMWFTYLLLYLHSVRAYSSRGAGLLLLLGQVADGLCTPLVGYEADRAAGRCARCGPRKAWHLVGTVCVLLSFPFIFSPCLGCGAATPEWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVVANITVFGAAWLLLRLQGSAREGPPDEAGDHLGVQDVPVFRTLSLCVVGVGAVFSLLFHLGTRERRRPPAQEPDERSPLLAPATARPLLLWKHWLREPSFYQVGLLYMSTRLIVNLSQTYIAMYLTYSLNLPKKFIATIPLVMYVSGFCSSFLMKPVNKCIGRNMTYFVGLLVILAFAAWVVLVDELGMAVYVAAVLLGGGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVMVIQSLHPCSLELCCRACVGFYHWVMVAVTGGVGVAATLSLCSLLVWPIRLRSWDPGAQP
Protein: Envelope glycoprotein H (gH) (P36336)
Organism: Gallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus type 1)
Function: The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
Subcellular location: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04033}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04033}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04033}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04033}. Host endosome membrane {ECO:0000255|HAMAP-Rule:MF_04033}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04033}. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). {ECO:0000255|HAMAP-Rule:MF_04033}.
Interaction partners:
Sequence:
MGLPGSIVFLIMIHAFCAKKTPTNTLPSLLSLLGITDLPSLRLNILSLDGSANNQGSWVRDNTTFVYIGASSPANGVLFYMPTSHVQQMTFYKRPVSKLLASNNLIKFLNTGSYINHSFMTAMPPYRRNVQIPSDRSGLKLDDKDDAQPTGTNPPTELKNLKPIDVVNPEHRFILTSELTGTYVKHVCFVDPMDMLIPVDYAHIRTIIFGSDGAEVIMKIGITFASITISMKSAPPVELILSERARNISLIWPALKPYEPVDKFTRRPYLIYLLGPHMNASDMEIKSYINMIESVEESSNYDFQIAQTHAQLFIFAATPISDINDIYCFRVVTTRLFMSLVASVRNAFQSGYISFDEIIKTEANIKMITETLSTFALHSNPGTYFLLSGMHLRNENADIIKSLIRKTIINASKNTASLSILQHLYVLRSAYAFNISQESGNLGEHVSSISLELIIALHEESVRDTIAWNTSARHALYYAFASIFQRPPNEWDASRTARKALLFASSMCTEEHIVATELVIQEMYIKINVKNSPVHILDVYTPCVTALRMDISEHHHRLYAMSDVILHPVIEKYLENDSRGIDAEEELETKAELVITKLKTPLMRRLTIYASEVVTCSDADILEATALLVLPISGLGSYVVTRQLGIRGIVYNVDGVDVNNQLYITYVRLPCTTTAGNIVPMVLPRPLGSDCPYCGCVLLRYSTNGNLRHTIYISSQDLQRELIAGGNSSIRYFNPTIAQIYGTSLLLYPNGTIVRILAFESERVTIISATYVATATAGASIAISIAIITVRMRINNFRYNYHRYKKLSLYDDL
Protein: Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (Phosphotyrosyl phosphatase activator) (Q24466)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU361210}.
Interaction partners:
Sequence:
MASGINQAAGKLPAIAKKVQNLGDMGVWQKSRAFHDLIGYINGTSSAIQGIKTTDEIFESEMLKKLLRLFDALEKLVEQNPPLEQPQRFGNKAYRDWAQAMRELLPELLEQLLPDDKKRYQVELGQYLTESFGNATRIDYGTGHELSFLFFLCSLFKAEILQERDIVSAALRRFNRYLEVARQLQRTYNMEPAGSQGVWSLDDFQFVPFIWGSAQLAVKSPFDPSKFVDEAIITEYKDHFMFISCIDYICKVKTGHFGEHSNQLWSITDVPTWAKINAGLVKMYQKEILSKFPVIQHVYFGELMTFEPVSSGTTLSNALLGHVAPPPSKRICIGTPNLVPPVPVATAPPPPAESLSIEQNVGDSSSESSDNSVVLRPSTSSSSLVAAAEGSGDKPSKE
Protein: Hepcidin (Q9EQ21)
Organism: Mus musculus (Mouse)
Function: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
Subcellular location: Secreted {ECO:0000269|PubMed:11113132, ECO:0000269|PubMed:15124018}.
Interaction partners:
- Ferroportin
- Hemojuvelin
- Hepcidin-2
- Hereditary hemochromatosis protein homolog
- Natural resistance-associated macrophage protein 2
- Transferrin receptor protein 2
- Erythroferrone
- Transmembrane protease serine 6
- Transferrin receptor protein 1
- Neutrophil gelatinase-associated lipocalin
Sequence:
MALSTRTQAACLLLLLLASLSSTTYLHQQMRQTTELQPLHGEESRADIAIPMQKRRKRDTNFPICIFCCKCCNNSQCGICCKT
Protein: DNA-directed RNA polymerase subunit (EC 2.7.7.6) (Q57YU2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- Plastid-encoded RNA polymerase subunit alpha
- RNA polymerase-like protein
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-direcetd RNA polymerase II, subunit 9, putative
- DNA-directed RNA polymerase II, putative
- DNA-directed RNA polymerase subunit
- Transcription initiation protein, putative
- Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2
Sequence:
MSGGAALPVSQMELHKVNEVQFEIFKERQIKSYAVCLVEHAKSYERGRPVRGGINDLRMGTTDFEFACETCHRKHPECPGHFGYIELAEPVFNIGVFDLVLQVLKCVCKTCGALLLNTREQDVHKKLQHMTGLNRLRQVAKMAEAKCRVSTSTEDDMGIDGFDSAPFNGGSGMGPGATRGCGASQPRVSRFYGIYPTLVIKAVHEEQDAEWHADKVRQVLDRVSDDDARLMGFDPQRCHPRDLVLTVLPVPPPQVRPAISFGGLRSDDELTHQIMSIVKRNNQLRRDKESDVQAAIDRSRALLQEHVATYFNNASTYYKPTKVNDTKKLKSLTERLKGKYGRLRGNLMGKRVDFSARTVITGDPNIDVDEVGVPFSVAMTLTFPERVNTVNKKRLTEFARRTVYPSANYIHHPNGTITKLALLRDRSKVTLNIGDVVERHVINGDVVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSLLGSYRLTDKDTFLDKYFVQSVALWLDLWQLPIPAILKPRPLWTGKQVFSLILPEVNHPATPQDRPPFPHNDSVVMIRRGQLLCGPITKSIVGAAPGSLIHVIFNEHGSDEVARFINGVQRVTTFFLLNFGFSVGVQDTVADSDTLRQMNDVLVKTRRNVEKIGAAANNRTLNRKAGMTLLQSFEADVNSALNKCREEAAKKALSNVRRTNSFKVMIEAGSKGTDLNICQIAVFVGQQNVAGSRIPFGFRRRTLPHFMLDDYGETSRGMANRGYVEGLKPHEFFFHTMAGREGLIDTAVKTSDTGYLQRKLIKALEDVHAAYDGTVRNANDELIQFMYGEDGLDGARIEGGQLFPLPFRDDKEMEDTYKYEYDVDGTFSGKVGGNYMDPHVRKMLRADPQNVRKLQEEYEQLTADREWSRKMLDLEDRDKLKLNLPVNPGRLIQNARSTMGKRSQVSNLSPITIIDHVRKLQEDLMKLFPSYHRGGDGYIRNTLSRERIESALTLFNVHLRQLLASKRVLKEYKLNDRAFEYLLKEIRTKYHQSLTTPGENIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLGVPRLLELLNVSRNQKHASMTVSLFPPYDEKRNAQKAQHLIEYCTLESITRRIQFIYDPDPRHTVVEADRDILELEWNVMDESDAELRIQEVVAGSPWVVRLELDVDMVTDKALDMKDVKQAILRVDESYIIETGMANNVRQRTIRMRSRYNEGADSIPQLKREIPALLARVHLRGIPGVRRALLKDTTEFTVDQATGKMSGNKIWAIDTDGTALRRAFIGVVGEDGKNIINAVKTSSNKVPEVCSLLGIEAARSKMLTELREAYLAYGLNINYRHYTILVDTICQHGYLMAVSRSGINRSDTSGPLMRCSFEETVKVLMAAASFGECDPVRGVSANLVLGNQARVGTGLFDLVLNMAALQQAVPQAEAVAPGKDVNVYHSLGSTLQQNIQSSIAYRPRDHDATPFVNNASLFLRQGFGGGSSSAPVTASAPYNPSTTYHGGRLEASAVHRSQAYSTSPALEYGGREASASQMYSVMSSASAFNPVSTRMSSVAHSYSEYSEASSYHLQHSVAPTSMQASLPRTDNSMTMQGIGSVSVPYTPHAMSSAAPPSQVYASTEVGRSHSEDSRSQSALYVPTLSPTHAGYAIRGDEPSTHRSDSNVMWREAGGGREQDEEDDLSTNYMPTAKTPQQVAPPTAAEFGDEEEEEQ
Protein: Nicotinamide nucleotide adenylyltransferase 3 (A0A2R8YEU0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKSRIPVVLLACGSFNPITNMHLRMFEVARDHLHQTGMYQVIQGIISPVNDTYGKKDLAASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHSKLLRSPPQMEGPDHGKALFSTPAGILKRILQTLFEHLTGTDSGLRLRTETASPSPHLKLETGYEWRWPNRNSSSLQLPARAIQKTGDFCISN
Protein: [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) (A0A096MJZ8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKTFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEIVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPDLDLKEKVEAEVLSTDIQPSPERGTRMNIPPKRTRRVKSQSDSGEVNRNTELKKLQIFGAGPKVVGLAVGAKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLLPPLPDVPKGDWRCPKCVAEECNKPREAFGFEQAIREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPIKDGQRKMLPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVVMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCSCPMQNKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVNRVTEALSASFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCGSVAQLLLSKKQKHRQSSDSGKTRTKLTVEELKAFVQQLVSLPCVISQTRQVKNLLDDVEEFHERAQEAMMDETPDSSKLQVLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSMANLENIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLDALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKEIIEKEKEKDLDLEPLSDLEEGLEETRDAAMVVAVFKEREQKEIEAMHSLRAANLAKMTIVDRIEEVKFCICRKTASGFMLQCELCKDWFHNGCVPLPKSGSQKKGSSWQAKDVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPHQAMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSVEEKPLKMKGKDSSEKKRKRKLEKVEQFFGEGKQKTKELKKIDKPKKKKLKLNVDKSKELNKLAKKLAKEEERKKKKEKAAAAKVELAKESTEKKRERKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCKDKGVVFVTEEEKNKK
Protein: Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8) (O70461)
Organism: Rattus norvegicus (Rat)
Function: Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity).
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:9841555}; Multi-pass membrane protein {ECO:0000255}. Note=Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (By similarity). Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (By similarity). {ECO:0000250|UniProtKB:O35308, ECO:0000250|UniProtKB:O95907}.
Interaction partners:
- Basigin
Sequence:
MGAGGPRRGAGPPDGGWGWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGFLLFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRARHRQLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAVTTYCCQRCSKDIPPGPSAEGGTSDTEDVEAERDSEPMPASTEEPGSLEALEVLSPRAGSPEPEEEAVPDLSHESVGGHEAHGQNA
Protein: Tectonic-like complex member Mks1 (Meckel syndrome type 1 protein homolog) (Q9VYM3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:25447994, ECO:0000269|PubMed:27577095, ECO:0000269|PubMed:27646273, ECO:0000269|PubMed:30013109}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27646273}. Note=Localizes at the transition zone (TZ), a region between the basal body and the ciliary axoneme in the olfactory, auditory and speromatocyte system (PubMed:27646273, PubMed:30013109). In spermatocytes, localizes in the transition zone and the migrating base of the spermatid ciliary cap (PubMed:25447994, PubMed:27577095, PubMed:27646273). Co-localizes with the tectonic-like complex (PubMed:27646273). {ECO:0000269|PubMed:25447994, ECO:0000269|PubMed:27577095, ECO:0000269|PubMed:27646273, ECO:0000269|PubMed:30013109}.
Interaction partners:
- B9 domain-containing protein 1
- Coiled-coil and C2 domain-containing protein 2A
- B9 domain-containing protein 2
- Tectonic
- Centrosomal protein Cep290
- GH21622p
- Uncharacterized protein, isoform C
- GEO07735p1
- Bardet-Biedl syndrome 9
Sequence:
MQKSRDIKRTGVYRVSGNIGDLQLELKLRHISEWLPVPKFEYAGAQSTNAYGDHYPGSEEDIWQDCYIHVPQGDDSCGGKTGLGYNCSYYNVGIGYTGRRRRSPISQHEGEMEKDKNEGEITDLESQSNRSWSILSDNSRPPAGDLFYKRNKELCNGAIATIRISWQQKHFSQAELEQYINNPGSCASKLQRRYHRWALETLKLQQRYLRKLENLEDAETVEDPEPITIRRRIRKPKAKQRGCSAAAHPTITSLSSANMSEVSILDDPNFAARTCLIHTLLDNDSESLMPAEASEFHKKGYQLMYIYADLQQDTLLVSIRYDPEQGLLYVYPDFSSSAQDLDYVIQIERNNDCRQLYAFGFENVTPLEAYDDDGFSEEADGEDEQELGDGLPIEEDLPEEASAEEILEFYRRRREAASERRSLLQFEMPPKRMKRVSLLLELQEGQNFENPNIHVRYYLKAPANTFYEGTPGVDTMQGATATCRNAGDWRSAHLGHCWQVTLLLEEQHHPADLLHLYFEVISIDSWQRERCEGYAHYAIPLTSALPTDSIRLQCIRPLGNWLDALNRYFIGGRQLFDFESFFDVHRQSEMHSRLNFNSDRPMTTTGTLSLRLQKLQQRQIDTSDQFHHHFHLELGNDSSDDGDSNDDDVRSSSNPDTSRATTLDEVMAAFVEARKRIELLLGNSSETASPSSAYYQAEF
Protein: Dynein regulatory complex protein 1 (Coiled-coil domain-containing protein 164) (Q32KY1)
Organism: Bos taurus (Bovine)
Function: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:P0DL09}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:P0DL09}.
Interaction partners:
- Dynein regulatory complex subunit 4
- Dynein regulatory complex subunit 3
- Dynein axonemal intermediate chain 2
- Dynein regulatory complex subunit 2
- Coiled-coil domain 40 molecular ruler complex subunit
- Coiled-coil domain containing 103
- Coiled-coil domain-containing protein 39
- Cilia and flagella associated protein 45.
- Dynein axonemal heavy chain 5
- Dynein axonemal intermediate chain 1
Sequence:
MNPPGSLGVLEEKEEEHLAPPILGPSIHSDNPQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAADIREIHRRVEEEEIKRQRLEKLENEVKTSQDKFDEITVKWEEGKQRRIPQELWEMLNAQQVHCAGLIEDKNKLISELQQELKMKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFRQELQNIEKAFEVERQELLTSNKKKWERALQAHNAKELEYLMNRIKKVEDYEKQLNKQRIWDCEEYNTIKIKLEQDVQILEQQLQQMKATYQLNQEKLEYNFQVLKKRDEESTVIKSQQKRKINRLHDVLNNLRSKYNKQVKQFQEENQSLTSDYKRLVLQFKELQKAMRHFALIDDKRFREIWLMNEEEAKDLINRAFDVDRIISTHHLGLPWMAPDFWFLKNVGPISQQQQKSATQILEEVLMEAEKEGADEDSSESETYLDLPKQVSARTTRKILMLLCDESGFLIESKLLSLLLPLEKNECYLLRLDAVFSALGIENEDDLYKLVNFFLKYQTHHSPSSQEPLDLRAEKERSLVDGKSQEKEPPPSPKLIHPNDVLKILEAFVMSLRKPRDFWVPVKLLKAVRDDSKDSEYWEALTTVIPATTLNLWDALYTALEKYHLVLTQRAELLIENSSLERQNTELQQLLQQYLDTKINSELQVPPTQVFRVPTK
Protein: E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) (E7FAM5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development.
Subcellular location: Cytoplasm, P-body {ECO:0000250|UniProtKB:Q2Q1W2}.
Interaction partners:
- Protein lin-28 homolog A
Sequence:
MCEVILWSSAQMASFPDSDLQTCPLCKELCGCSAPISSNSSTSSSSSQTSNSSSTSSTRRLHVLPCLHAFCRQCLEGQRSPGDPLKLRCPTCDQKVSLSESGVDALPSSNFLFSNLLDVVVSAEEQGKNGRSSAVVHHGGLLRPQHLSDPQCSSCDEGNPATSHCLDCQEYLCDNCVRAHQRVRLTKDHFIEGLLESLHLANRTNNSNTPVSISQSFHNSFSMLNVFQERMDFCQHHDDAVLRFFCDSCTVPICRECSLGRHAGHSFTYLQDALQDSRALTIQLLADAQQGRQAIQLSIEKAQAIAEQVELKAKVVQSEVKTITLRHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLHQNLTKLDSTIATVTQVLEEGRSIDVLLAREHMLNQLQELKSLRCILQPQEDDRIMFTPPDQALLIAIKSLGLISSGAFATASKAHGEGIKRALQGKPASFTVVGYDHDGEPRLSGGDSVSVVLMSPDGNLSSAEVSDHQDGTYTVSYLPKGEGEHLLSVLICNQHIEGSPFKVMVKSGRSYGGVGLPMASFGGEGDGDGQLCRPWGICVDKEGYVVVADRSNNRVQIFKPCGTFHHKFGTLGSRPGQFDRPAGVACDSQRRIIVADKDNHRIQIFTFDGQFLLKFGEKGTKNGQFNYPWDVAVNFEGKILVSDTRNHRVQLFGPDGTFLNKYGFEGALWKHFDSPRGVAFNQEGHLVVTDFNNHRLLVIRPDCQSARFLGSEGTGNGQFLRPQGVAVDQEDRIIVADSRNHRIQVFEPNGNFLCKFGTHGNGFGQMDRPSGIAVTPDGVIVAVDFGNNRILMF
Protein: Protein translocase subunit SecA (EC 7.4.2.8) (P10408)
Organism: Escherichia coli (strain K12)
Function: Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01382}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01382}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_01382}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01382}. Note=Distribution is 50-50. {ECO:0000255|HAMAP-Rule:MF_01382}.
Interaction partners:
- Protein-export protein SecB
- Protein translocase subunit SecE
- Protein translocase subunit SecY
- Protein-export membrane protein SecG
- Sec translocon accessory complex subunit YajC
- Membrane protein insertase YidC
- Signal recognition particle protein
- Signal recognition particle receptor FtsY
- Protein translocase subunit SecD
- Maltoporin
Sequence:
MLIKLLTKVFGSRNDRTLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVLENLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGLTVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKRVNKIIPHLIRQEKEDSETFQGEGHFSVDEKSRQVNLTERGLVLIEELLVKEGIMDEGESLYSPANIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLNAKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKADWQVRHDAVLEAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYSQRNELLDVSDVSETINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLDLPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEELEQQRRMEAERLAQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCPCGSGKKYKQCHGRLQ
Protein: RAD54 like (V9GYX6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRRSLAPSQLAKRKPEGRSCDDEDWQPGLVTPRKRKSSSETQIQECFLSPFRKPLSQLTNQPPCLDSSQHEAFIRSILSKPFKVPIPNYQGPLGSRALGLKRAGVRRALHDPLEKDALVLYEPPPLSAHDQLKLDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPECKPE
Protein: Protein AF1q (P97783)
Organism: Mus musculus (Mouse)
Function: Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T-cell fate.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13015}. Cytoplasm {ECO:0000250|UniProtKB:Q13015}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q13015}. Note=Continuous nuclear export is followed by degradation. {ECO:0000250|UniProtKB:Q13015}.
Interaction partners:
Sequence:
MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTPTYESKDSSSVGKMNGQASGTEQKNPEGDPLLEYSTFNFWRAPIASIHSVDLDLL