wanglab/gogpt-training-data huggingface dataset:
Protein: Insulin like growth factor 2 receptor (F1MIE6)
Organism: Bos taurus (Bovine)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004608}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
Interaction partners:
Sequence:
MEAAAGRSSHLGPAPAGRPPRCPLLLQLQLLLLLLLLPPGWVPGAAGTQGAEFPELCSYTWEAVDTKNNMLYKINICGNMGVAQCGPSSAVCMHDLKTDSFHSVGDSLLKTASRSLLEFNTTVNCKQQNHKIQSSITFLCGKTLGTPEFVTATDCVHYFEWRTTAACKKNIFKANKEVPCYAFDRELKKHDLNPLIKTSGAYLVDDSDPDTSLFINVCRDIEVLRASSPQVRVCPTGAAACLVRGDRAFDVGRPQEGLKLVSNDRLVLSYVKEGAGQPDFCDGHSPAVTITFVCPSERREGTIPKLTAKSNCRFEIEWVTEYACHRDYLESRSCSLSSAQHDVAVDLQPLSRVEASDSLFYTSEADEYTYYLSICGGSQAPICNKKDAAVCQVKKADSTQVKVAGRPQNLTLRYSDGDLTLIYFGGEECSSGFQRMSVINFECNQTAGNNGRGAPVFTGEVDCTYFFTWDTKYACVHEKEALLCGVSDGKQRFDLSALARHSELEQNWEAVDGSQREAEKKHFFINICHRVLQTGQARGCPEDAAVCAVDKNGSKNLGRFISSPTREKGNIQLSYSDGDECGGGQKIITNITLMCKPGDLESAPVLTTSRADGCFYEFEWRTAAACVLSRTEGDNCTVFDSQAGFSFDLTPLTKKDAYKVETDKYEFHINVCGPVSVGACPPDSGACQVSRSDRKSWNLGRSNAKLSYYDGMIQLTYRDGTPYNNEKRTPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECIVTDPVTLDQYDLSRLAKSEGGPGGNWYSLDNGGARSTWRKYYINVCRPLNPVPGCDRYASACQMKYQGEQGSYSETVSISNLGVAKTGPMVEDSGSLLLEYVNGSACTTSDQRRTTYTTRIHLVCSTGSLYTHPIFSLNWECVVSFLWNTAAACPIRITTDIDQVCSIKDPNSGYVFDLNPLNNSRGYVVLGIGKTFLFNVCGDMPACGTLDGKPASGCEAEVQMDDMKTLKPGRLVGLEKSLQLSTEGFITLNYTGLPSHPNGRADAFIIRFVCNDDVYPGTPKFLHQDIDSSLGIRDTFFEFETALACVPSPVDCQVTDPAGNEYDLSGLSKARKPWTAVDTFDEGKKRTFYLSVCTPLPYIPGCHGTAVGSCLVTEDSKLNLGVVQISPQVGANGSLSLVYVNGDKCKNQRFSTRINLECAHTTGSPTFQLQNDCEYVFLWRTVEACPVVRAEGDYCEVRDPRHGNLYNLIPLGLNDTVVRAGEYTYYFRVCGELTSGVCPTSDKSKVISSCQEKRGPQGFQKVAGLFNQKLTYENGVLKMNYTGGDTCHKVYQRSTTIFFYCDRSTQAPVFLQETSDCSYLFEWRTQYACPPYDLTECSFKNEAGETYDLSSLSRYSDNWEAVTGTGSTEHYLINVCKSLSPQAGSDPCPPEAAVCLLGGPKPVNLGRVRDSPQWSQGLTLLKYVDGDLCPDQIRKKSTTIRFTCSESHVNSRPMFISAVEDCEYTFSWPTAAACAVKSNVHDDCQVTNPATGHLFDLSSLSGRAGFTAAYSEKGLVYLSVCGDNENCANGVGACFGQTRISVGKASKRLTYVDQVLQLVYEGGSPCPSKTGLSYKSVISFVCRPEVGPTNRPMLISLDKRTCTLFFSWHTPLACEQTTECSVRNGSSLIDLSPLIHRTGGYEAYDESEDDGSDTSPDFYINICQPLNPMHGLACPAGTAVCKVPVDGPPIDIGRVAGPPILNPIANEVYLNFESSTPCLADRHFNYTSLITFHCKRGVSMGTPKLLRTSVCDFVFEWETPLVCPDEVKTDGCSLTDEQLYYSFNLSSLSKSTFKVTRGPHTYSVGVCTAAAGLDEGGCKDGAVCLLSGSKGASFGRLASMKLDYRHQDEAVILSYANGDTCPPETEDGEPCVFPFVFNGKSYEECVVESRARLWCATTANYDRDHEWGFCKHSTSHRTSVIIFKCDEDADVGRPQVFSEVRGCEVTFEWKTKVVCPPKKMECKFVQKHRTYDLRLLSSLTGSWSFVHNGASYYINLCQKIYKGPQDCSERASVCKKSTSGEVQVLGLVHTQKLDVVDDRVIVTYSKGHYCGDNKTASAVIELTCAKTVGRPSFTRFDVDSCTYHFSWDSRAACAVKPQEVQMVNGTITNPANGRSFSLGDIYFKRFSASGDVRTNGDRYIYEIQLSSIMGSSSPACSGASICQRKANDQHFSRKVGTSNQTRYYVQDGDLDVVFTSSSKCGKDKTKSVSSTIFFHCDPLVKDGIPEFSHETADCQYLFSWHTSAVCPLGAGFDEEIAGDDAQEHKGLSERSQAVGAVLSLLLVALTACLLTLLLYKKERREMVMSRLTNCCRRSANVSYKYSKVNKEEEADENETEWLMEEIQPPAPRPGKEGQENGHVAAKSVRAADTLSALHGDEQDSEDEVLTLPEVKVRPPGRAPGAEGGPPLRPLPRKAPPPLRADDRVGLVRGEPARRGRPRAAATPISTFHDDSDEDLLHV
Protein: Chaperone protein ClpB1 (Q8IB03)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Endoplasmic reticulum chaperone GRP170
- Heat shock protein 70
- ATP-dependent Clp protease proteolytic subunit
- Heptatricopeptide repeat-containing protein
- ATP-dependent Clp protease proteolytic subunit
- Heat shock protein 110
- Heat shock 70 kDa protein
- Heat shock 70 kDa protein
- GrpE protein homolog
- Endoplasmic reticulum chaperone BIP
Sequence:
MVNSFFFCFVIIGLIYVWDITYSKKAKIFFNKNDIFSIKNTHWDIYDKKKYFFIGNNHLKNEESFLPEVRKDYKSQIKEYKNSTNGIIYHNNKNRLSYTINDQVNYDNNMTSGINKKRKVKDSSIHMNNSYEKNRNKNKFALFMSDEEYTINSDDYTEKAWEAISSLNKIGEKYDSAYVEAEMLLLALLNDSPDGLAERILKESGIDTQLLVQEIDDYLKKQPKMPSGFGEQKILGRTLQTVLSTSKRLKKEFNDEYISIEHLLLSIISEDSKFTRPWLLKYNVNYEKVKKAVEKIRGKKKVTSKTPEMTYQALEKYSRDLTALARAGKLDPVIGRDNEIRRAIQILSRRTKNNPILLGDPGVGKTAIVEGLAIKIVQGDVPDSLKGRKLVSLDMSSLIAGAKYRGDFEERLKSILKEVQDAEGQVVMFIDEIHTVVGAGAVAEGALDAGNILKPMLARGELRCIGATTVSEYRQFIEKDKALERRFQQILVEQPSVDETISILRGLKERYEVHHGVRILDSALVQAAVLSDRYISYRFLPDKAIDLIDEAASNLKIQLSSKPIQLENIEKQLIQLEMEKISILGDKQKNLFNYSSVANTHNNNNNSSISSNNSSSYGNAEETEATVDYTKSPNFLKKRINEKEIDRLKMIDRIMSELRKEQRKILDSWSTEKSYVDNIRAIKERIDVVKIEIEKAERYFDLNRAAELRFETLPDLEKQLKKAEENYLNDIPEKSRILKDEVTSEDIVNIVSMSTGIRLNKLLKSEKEKILNLENELHKQIIGQDDAVKVVTKAVQRSRVGMNNPKRPIASLMFLGPTGVGKTELSKVLADVLFDTPEAVIHFDMSEYMEKHSISKLIGAAPGYVGYEQGGLLTDAVRKKPYSIILFDEIEKAHPDVYNLLLRVIDEGKLSDTKGNVANFRNTIIIFTSNLGSQSILDLANDPNKKEKIKEQVMKSVRETFRPEFYNRIDDHVIFDSLSKKELKEIANIEIRKVANRLFDKNFKITIDDAVFSYIVDKAYDPSFGARPLKRVIQSEIETEIAVRILDETFVENDTINISLKDQKLHFSKS
Protein: Pullulanase A (EC 3.2.1.41) (Alpha-dextrin endo-1,6-alpha-glucosidase) (Pullulan 6-glucanohydrolase) (Q9F930)
Organism: Streptococcus pneumoniae
Function: Virulence factor (By similarity). Involved in the degradation of glycogen of the mammalian host cells. Hydrolyzes the alpha-1,6-branchpoints of glycogen (By similarity). Hydrolyzes pullulan. Does not hydrolyze dextran. Binds to mouse lung alveolar type II cells that are rich in glycogen stores. Is an alpha-glucan-specific carbohydrate-binding protein, which binds to amylose (pure alpha-(1,4)-linked glucose), amylopectin (alpha-(1,4)-linked glucose with alpha-(1,6) branch points), pullulan (linear polymer of mixed alpha-(1,4)- and alpha-(1,6)-linked glucose) and glycogen (similar to amylopectin with more frequent alpha-(1,6) branch points) in vitro. Does not bind to dextran (a linear polymer of alpha-(1,6)-linked glucose) (By similarity).
Subcellular location: Secreted, cell wall {ECO:0000255|PROSITE-ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-ProRule:PRU00477}. Cell surface {ECO:0000269|PubMed:11083842}. Note=Localizes to cytoplasm in the lung alveolar type II cells of the mouse and human hosts. {ECO:0000250|UniProtKB:A0A0H2UNG0}.
Interaction partners:
Sequence:
MRKTPSHTEKKMVYSIRSLKNGTGSVLIGASLVLLAMATPTISSDESTPTTNEPNNRNTTTLAQPLTDTAAGSGKNESDISSPGNANASLEKTEEKPATEPTTPAASPADPAPQTGQDRSSEPTTSTSPVTTETKAEEPIEDNYFRIHVKKLPEENKDAQGLWTWDDVEKPSENWPNGALSFKDAKKDDYGYYLDVKLKGEQAKKISFLINNTAGKNLTGDKSVEKLVPKMNEAWLDQDYKVFSYEPQPAGTVRVNYYRTDGNYDKKSLWYWGDVKNPSSAQWPDGTDFTATGKYGRYIDIPLNEAAREFGFLLLDESKQGDDVKIRKENYKFTDLKNHSQIFLKDDDESIYTNPYYVHDIRMTGAQHVGTSSIESSFSTLVGAKKEDILKHSNITNHLGNKVTITDVAIDEAGKKVTYSGDFSDTKHPYTVSYNSDQFTTKTSWRLKDETYSYDGKLGADLKEEGKQVDLTLWSPSADKVSVVVYDKNDPDKVVGTVALEKGERGTWKQTLDSTNKLGITDFTGYYYQYQIERQGKTVLALDPYAKSLAAWNSDDAKIDDAHKVAKAAFVDPAKLGPQDLTYGKIHNFKTREDAVIYEAHVRDFTSDPAIAKDLTKPFGTFEAFIEKLDYLKDLGVTHIQLLPVLSYYFVNELKNHEHLSDYASSNSNYNWGYDPQNYFSLTGMYSSDPKNPEKRIAEFKNLINEIHKRGMGAILDVVYNHTAKVDIFEDLEPNYYHFMDADGTPRTSFGGGRLGTTHHMTKRLLVDSIKYLVDTYKVDGFRFDMMGDHDAASIEEAYKAARALNPNLIMLGEGWRTYAGDENMPTKAADQDWMKHTDTVAVFSDDIRNNLKSGYPNEGQPAFITGGKRDVNTIFKNLIAQPTNFEADSPGDVIQYIAAHDNLTLFDIIAQSIKKDPSKAENYAEIHRRLRLGNLMVLTAQGTPFIHSGQEYGRTKQFRNPAYRTPVAEDKVPNKSHLLRDKDGNPFDYPYFIHDSYDSSDAVNKFDWTKATDGKAYPENVKSRDYMKGLIALRQSTDAFRLKSLQDIKDRVHLITVPGQNGVEKEDVVIGYQITAPNGDIYAVFVNADEKAREFNLGTAFAHLRNAEVLADENQAGSVGIANPKGLEWTEKGLKLNALTATVLRVSQNGTSHESTAEEKPDSTPSKPEHQNEASHPAHQDPAPEARPDSTKPDAKVADAENKPSQATADSQAEQPAQEAQASSVKEAVRKESVENSSKENISATPDRQAELPNTGIKNENKLLFAGISLLALLGLGFLLKNKKEN
Protein: Monopolin complex subunit mde4 (Mei4-dependent protein 4) (O43068)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules.
Subcellular location: Nucleus {ECO:0000269|PubMed:17627824}. Chromosome, centromere {ECO:0000269|PubMed:17627824}. Note=Localizes to the central core of the centromere.
Interaction partners:
- Monopolin complex subunit pcs1
- Kinetochore protein spc25
- Kinetochore protein spc24
- Inner kinetochore subunit fta1
Sequence:
MSTISTSTDSKLDNLGLSVTSRRNQILFYLSKALNLAHLLRSDSLQKSFLDALKQSATDSELLHKNLDEIKFLQNEKLNNEKLLEQEQNEANDYRLKVERLEHKISDYVQEINSLNSQLQIQKSNPEKHEDAVSQNRLRGSLDTVSSPSKTHKANKDEKATRLHLIIANLKKALKEKDAEVLNLQSHVSSKESELDRFKIKLETEESNWKVRLQVLESKLATQDRKLRMQKKSTERKSLLVSPRVSSPKLFSPSKQAIMGTRQPNATSGSPLSVTPFLQKTSTSIGLSSSPPQSSPSAQSSQPFSRDKYPHSMTVSPSNARYLKKHLDDTIPSNVSDINHNDHLKIPQSPSSLSPSKIPIRKKRKLKDTVSNCEFTEEDSESSFLLETIQPTKSTLRRSISPLKKRNDEINELKKGFTMKK
Protein: Inositol 5-phosphatase (Q54PV1)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Inositol 5-phosphatase 4
- Pre-mRNA-processing factor 19
Sequence:
MKVLYTWGKGKTGNTCHNIDKKYPSPPSVLISLNLDQLSMGPNHSAAIVNNECLMWGEVMGRKHTTLFKIVWKRRVVSVSCGFNHTLLLTSEYKIFSMGFNQTGQLGIENVVDSAVPLPVDTLSKFNVIKIKAGNNVSAAITEAGDLYCWGSSAYGQLGNGKMNAKLHSFTPTTILNPLIPDAEKDDPIYQNLQYTNICFGAQHTIAISTTGAIFSWGSNQYGQLGLGHCNAKLVPVPIHLDNSFERRAGHINSLGEIVTTDFTAKTIHRIVVDIACGNFHSALLTLEGDLFLWGSNQYGQLGQGDSLDQSVPKTVKGSLEFVKINRMALGNNHTILLTKEQDVFTFGSNEFYQLGHGSIGGKNRLYFPTQIQKPKVMASDIFAAGDCSAYFVLDDSPVHLNLLGQHQLLNGAGGNGGGGGSSNNNNNLLNNYNNGLMGSTNKHLSIFVGTWNCNAKRTQNLANWILTNSFAPDIIVLGLQEIVNMKAGAIVKATAADKQNNKENAYHPWKHDIEQTLSLSSGGRYVKVMNKVLVGLMILVYVKEEHAPYISEVSGAVVPCGMMGKIGNKGGLGVRFTLYKTGICFVNSHLAAGPSHEKMERRTQDYKKIQMMTFENHLSMLDHECLIWFGDLNYRIDLPYSETKALIEQKNWQKLQAHDQLNNERKAGKAFIGFKEELTNFAPSYKYDIGVNQYDTSEKNRTPSWCDRIIYRGESLKQISYQRHELMESDHRPISAIFLLETKEYIHAESSKAWSKFKHKDHANRSDSPDPFFSKIGSAAHHFSPVELKSSSSSINSTNSSVDSLVGSISSSNTTNSTNTTTDSINIINTSTKRNLPNLPAPPLPPKSNAVKKSLLNIHQHHSHSGSGSIGGSSSGNPFVVGSMPTFSPHFMYSNSPTSSDTSTNSGVTLNDSPMIRSILKNNAINKRLSFSAEDIHSVKVLSNHRKIKLNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGDNKNNNEVGNINNNNNEVGNINNINNNNNNNNNSNDINNNSNLIIEKEINNKSQQQQEEETNSPNLQPTDNSNSTNTRPPSSSLLSSVINSLETATSIDSPPMFSLNSDDNVDSSMENRNFTNDNEYIGQNNVNNEKDNNHNSHHNVDVDDDDVIIIKPMQQKTIVDRKGKRKTVLINTFDSIDSLGGSEALEIAKDSLNYPHHTDDEEDEDDGDDEEEEEEEDEEDDEDFIDSESDSDVGGYCSSMPTLNSLGDSGACHLEDLPLNFLKNREINYGYDHIGHSSSSNNNSTNNLGDYISSISPRAITSTTLTKNPKQEIERELENSVNNSNNNNSINNNSNNNNNNNTNNNNNTNNNNNTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSDKNSDSEEASIGSGILGNIDDIQNIIGNIKNGDQVNKNLNHKKSNSVEVVVVEHHDEENCSNDIFYIEPFTIVDQYTNNNNNNNNNNNNNNNNNNNDNNNDNNNDNNNDNDNNDNNNSGATITITPRSSPIKDSELKSMIRNSLSGLEPMVVSSSNTPPIVSSPSVNTITPKQSPSSKSIQSLKNESEFICVSPSSPSRVLFNPIFDKSFFEQKHRVVNTDIVLGSHKRSSPPVISPIGEFNSTTNSTTNSTTNSTTNSNSNINTKTNAINNNNKSDRELDKLKTKSGGSSFINIKSANSSRNNSMIYHSIENRHNNYNSDDSEDDGISYNINSDSDSDSDSHSDTNENSNINIEPKTIEPKIIEPTTSIATTTEPTTSTEIETNTTVTTSTDPKLPTEKEGSSL
Protein: D-3-phosphoglycerate dehydrogenase 2, chloroplastic (PGDH) (EC 1.1.1.95) (O04130)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the plastidial phosphorylated pathway of serine biosynthesis (PPSB).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:24058165, ECO:0000269|PubMed:24368794, ECO:0000269|PubMed:9867856}.
Interaction partners:
- Phosphoserine aminotransferase 1, chloroplastic
- Phosphoserine aminotransferase 2, chloroplastic
- Phosphoserine phosphatase, chloroplastic
- D-glycerate 3-kinase, chloroplastic
- D-3-phosphoglycerate dehydrogenase 1, chloroplastic
- Serine--glyoxylate aminotransferase
- Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1
- Phosphoglycerate mutase-like protein 4
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2
Sequence:
MAFSSSCSSVKAVNSRWTSPSPSPSSRFAVLPAFLHRRYATSVKLTAISAALKTVEQTTLTEDNRFSTVGSDSDEYNPTLPKPRILVTEKLGEAGVNLLREFGDVDCSYDLSPEDLKKKVAESDALIVRSGTKVTREVFEAAKGRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVAQADASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADRARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDALVRALDAGIVAQAALDVFCEEPPSKDSRLIQHENVTVTPHLGASTKEAQEGVAIEIAEAVAGALKGELSATAVNAPMVAPEVLSELTPYIVLAEKLGRLAVQLASGGKGVQSIRVVYRSARDRDDLDTRLLRAMITKGIIEPISDSYVNLVNADFIAKQKGLRISEERMVVDSSPEYPVDSIQVQILNVESNFAGAVSDAGDISIEGKVKYGVPHLTCVGSFGVDVSLEGNLILCRQVDQPGMIGQVGNILGEQNVNVNFMSVGRTVLRKQAIMAIGVDEEPDNKTLERIGGVSAIEEFVFLKL
Protein: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas) (Q6R0H7)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q63803}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63803}. Apical cell membrane {ECO:0000250|UniProtKB:Q5JWF2}.
Interaction partners:
- Beta-2 adrenergic receptor
- Prostaglandin E2 receptor EP2 subtype
- Prostaglandin E2 receptor EP4 subtype
- Glucagon-like peptide 1 receptor
- Guanine nucleotide-binding protein G
- D
- Glucose-dependent insulinotropic receptor
- Beta-1 adrenergic receptor
- D
- Parathyroid hormone/parathyroid hormone-related peptide receptor
Sequence:
MGMFNCLHGNNMSGQHDIPPEVGEQPEQEPLEAPGAAAPGAGAGPAEEMATEPDSEPSNNEPVPDETGSEISGPPEDSKSDIQSPCQAFEEVRVGGDYSPPPEEAMPFETQQPSLGDFWPTLEQPGPSGTPSGLQAFNPAILEPGTPTGASPGLGAYTPPPEEAMPFEFNEPAQGDHSQPPLQVPDLAPGGPEALVPRALPAEPGNIRFENAGFREDYSPPPEESVPFQVGGEEFGGDSPPPGLPRVIPQIGIGGEFPTVAVPSALCLAPAENAPPLWVRGAIDRPFREAVRSPPNFACDSPPMEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSECAERPPVEREAAEMEGSPTTATAVEGKVPSPERGDGSSTQPEAMDAKPAPAAQAVSTGSDAGAPTDSAMLTDSQSDAGEDGTAPGTPSDLQSDPEELEEAPAVRADPDGGAAPVAPATPAESESEGSRDPAAEPASEAVPATTAESASGAAPVTQVEPAAAAVSATLAEPAARAAPITPKEPTTRAVPSARAHPAAGAVPGAPAMSASARAAAARAAYAGPLVWGARSLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRAHLRPPSPEIQVADPPTPRPPPRPTAWPDKYERGRSCCRYEASSGICEIESSSDESEEGATGCFQWLLRRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLSECTRSRSLSPGKAKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
Protein: Acireductone dioxygenase 2 (Acireductone dioxygenase (Fe(2+)-requiring) 2) (ARD' 2) (Fe-ARD 2) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring) 2) (ARD 2) (Ni-ARD 2) (EC 1.13.11.53) (Q8GXE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03154}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03154}.
Interaction partners:
- Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1
- Aromatic aminotransferase ISS1
- At1g77670
- Guanine nucleotide-binding protein subunit beta
- Acireductone dioxygenase 4-requiring) 4)
- Acireductone dioxygenase 3-requiring) 3)
- Acireductone dioxygenase 1-requiring) 1)
- Probable plastidic glucose transporter 3
- Protein NDL1
- Protein THYLAKOID FORMATION 1
Sequence:
MGEAVKDGREEVIQAWYMDDSEEDQRLPHHKDPKEFVSLDKLAELGVLSWRLDADNYETDEDLKKIRESRGYSYMDFCEVCPEKLPNYEVKVKSFFEEHLHTDEEIRYCVAGTGYFDVRDRNEAWIRVLVKKGGMIVLPAGIYHRFTVDSDNYIKAMRLFVGEPVWTPYNRPHDHLPARKEYVDNFMINASA
Protein: Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) (Q99808)
Organism: Homo sapiens (Human)
Function: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:23639800}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:11584005, ECO:0000269|PubMed:15501974, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:26406980}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral membrane of Sertoli cells (PubMed:23639800). Localized to the cell membrane of erythrocytes (PubMed:11584005, PubMed:23219802). {ECO:0000269|PubMed:11584005, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:23639800}.
Interaction partners:
- Equilibrative nucleoside transporter 3
- Equilibrative nucleoside transporter 2
- Sodium/nucleoside cotransporter 1
- Solute carrier family 28 member 3
- Sodium/nucleoside cotransporter 2
- Adenosine receptor A1
- Deoxycytidine kinase
- Adenosine deaminase
- Adenosine kinase
- Adenosine receptor A2a
Sequence:
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
Protein: Polycomb protein mes-3 (G8JY65)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTPATAEVKVGGRKRKNDEPVFIKTKQSRSARREEEKENLLNKSLPSTPTSSEAGSSRESSNPVTSSSRRKNPPTKLENIQKTLPTCSDGLEIRNYVKKYGLPEDNKFLVRNVFDKQLLFGKKYVCRRRVIKSIDEFFPRLKTDAHRENGLYNFCTLQFMKISSWGSSMDEKIYVTSAAIVQSYVIIVDDNDSVTCIENGISVIPMANRTLPSISYNSSNVKNITLTGPELKKAKNVYLAVIVKRKTPKLGENRVGTRGKSTRASFETAASSENFQQLVRFGCTLMYDKDAEINCLNDGVQRIILLDREEKPAYLKIFGKADEPELENAWMNNVKHLEFISDTNYNKEDSHLARLIFSSNTHNYFDRPDISKFSPWQPRSRRTTLKSGTITLKQLLLGTKKLCGRRKRHLTRLTSRWPCFSVDPTKINSYFNETGVTLLENSCSYRPGTQRSIPIKPTRVIRVREETPVSVPIEVITIEDDSDDSPCFSARNRAPGGTRKYGLDFIQSSGHMPYIRYVYMNRANDLVPQLNGEENGKIEGLMEAYPMNNAHMYSDIEFLRKEKLNLPKNAQKYGEMTILDYPLTKTETDEYNKKMSVMNVKDFAVKPRKPIPTVGNTTLSLDLEGCPISTFSEIFFPSGKTELFNILCRHFYSEAGQRPGCFSAQWKSRVLTGFINKYHQYIFDMKLNSLFEKQINLIAMVSPDWKLEDFELPMVRYKQLKKEWKNRQRDIPSSN
Protein: Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) (Q5XJV7)
Organism: Mus musculus (Mouse)
Function: Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion.
Subcellular location: Nucleus {ECO:0000269|PubMed:27864380}. Chromosome {ECO:0000269|PubMed:31515109}. Note=Localizes to active transcribed genes. {ECO:0000269|PubMed:31515109}.
Interaction partners:
- tRNA
- Inactive histone-lysine N-methyltransferase 2E
Sequence:
MSIAIPLGVTTPDTSYSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQRHGCRGLPYATIIPRSDLNGLPSPVEERCGDSPNSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPTSITLTVRRTKPKKRKKSPEKGRAAPKTKKIKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQNALEQHLHSNKEFVGKPAILDTINKTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNAAELPLPPPPSFPTIGAETRRRKARRKELELEQQNEVPEENPDPQPQEVPEKVTVSNEHEEVDNPEEKPEEEEKEEATDDQENSAHSRRTREDRKVEAIMHAFESLEKRKKRRDQPVEQSSSDIEITTSSSEIVVGEETKTAAPESEVSSPVSNVAIPSTPQSTGVNTRRSSHAGDVAAEKPIPKPPPAKPSRPRPKSRISRYRTSSAQRLKRQKQAIAQQAELSQAALEEGGSNNSVTPPEAGNTDSSGENRQLTGSDPTVISVTGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFMPERRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQHLYQSNETSNSSSICKDNADLLSPLKKWKSRYLMEQNITKLLQPLSPVTPPPPSSGSKSPQLTTPGQTHPGEEECRNGYSLMFSPITSLTTASRSNTPLQFELCHRKDLDLTKVGFPDSSTHSCADRPSLLNCNHPDLASHPSVVPTSEAGFPSRSGDGPQTLLRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRYEHGFMKDLSRGSMSPGGERTCEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENSGGGNDSSQSKSKSSGAGQGSSNSVSDTGAHGVQGSSAGTPSSPHKKFSPSHSSASHLEAVSPSDSRGTSSSHCRPQENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPSPTWESNITEKESDPADGEGPEPLSSALSKGATVYSPSRYSYQLLQCDSPRTESQSLLQQSSSPFRGHPTQSPGYSYRTTALRPGNPPSHGSSESSLSSTSYPSPAHPVSTDSLAPFTGTPGYYSSQPHSGNSTGSNLPRRSCSSSAASPTPQGPSDSPTSDSVSQSSTGTLSSTSFPQNSRSSLPSDLRTISLPNAGQSAAYQASRVSAVSNSQHYPHRGSGGVHQYRLQPLQGSGVKTQTGLS
Protein: Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) (Q498D6)
Organism: Rattus norvegicus (Rat)
Function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 (By similarity).
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane. {ECO:0000250}.
Interaction partners:
- Fibroblast growth factor
- Klotho beta
- Fibroblast growth factor 2
- Fibroblast growth factor 1
- Fibroblast growth factor
- Fibroblast growth factor 23
- Fibroblast growth factor 9
- Fibroblast growth factor 17
- Fibroblast growth factor 18
- Fibroblast growth factor
Sequence:
MWLLLALLSIFQETPAFSLEASEEMEQEPCPAPISEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLIMDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPAEEEDLAWTTATSEARYTDIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPSPFPFPEAQTT