wanglab/gogpt-training-data huggingface dataset:
Protein: CyanoQ (Photosystem II lipoprotein PsbQ) (P73048)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Subcellular location: Cellular thylakoid membrane {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:12069591, ECO:0000269|PubMed:15258264, ECO:0000269|PubMed:17287351, ECO:0000269|PubMed:24550459}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000305|PubMed:18078799, ECO:0000305|PubMed:24550459}; Lumenal side {ECO:0000269|PubMed:24550459, ECO:0000269|PubMed:34937700}. Note=Associated with PSII at the lumenal side of the thylakoid membrane, binds to the large lumenal domain of PsbC (CP43) between PsbO and PsbV (PubMed:34937700). Contacts CP47 (psbB) and PsbO (PubMed:24550459). {ECO:0000269|PubMed:24550459, ECO:0000269|PubMed:34937700}.
Interaction partners:
- Photosystem II CP47 reaction center protein
- Photosystem II extrinsic protein O
- Photosystem II extrinsic protein V
- Photosystem II extrinsic protein U
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein Y
- Photosystem II reaction center protein X
- Photosystem II reaction center protein M
- Photosystem II reaction center protein J
- Photosystem II reaction center protein Z
Sequence:
MSRLRSLLSLILVLVTTVLVSCSSPQVEIPTTYSPEKIAQLQVYVNPIAVARDGMEKRLQGLIADQNWVDTQTYIHGPLGQLRRDMLGLASSLLPKDQDKAKTLAKEVFGHLERLDAAAKDRNGSQAKIQYQEALADFDSFLNLLPQAS
Protein: Bptf protein (Q6P9L3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAAKAPPGGGSTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPEAPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIESWVAEEELELWEIRAFAERVEKEKAQAAEQQTKKRLEQQKPAVIAASTTSPANNTSSTVSPAQKVMVAPLSGSVTPGTKMVLATKVGSPATVTFQQNKNFHQTFATWVKQGQSNSGMVQVQQKVLGIIPSTTGPSQQTFTSFQPRTATVTIRPNTSASAGTTTTSQVITGPQIRPGMTVIRTPLQQPALGKAIIRTPVVVQPGTPQQVVTQIIRGQPVSTAISAPSTASSAPVQKGLTPGAAAGPLQPSAPHSPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGMTVLPGPGQQLMQAAMPNGTVQRFLFTPLSTSATAASSSSNSSSTTTNATAAGSGEQKQSKILPQTQVQPATTLAPTQSSSVSPAEAQPQPAQPAAQPQPQPQPPAQPEVQTQPAVSSHVPSETQPSQAQTSKPLVATQCQPQSSVQGQSPVRVQSPPLTRIRPSTPSQVTPGQQPQVQTTASQPIPIPPPTSLQAPSQGQPQSQPQVQSSTQTLSSGQTLNQVTVLSPSCPQPQPQVIAVPQLQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQVQQNSAAQTQSVVTVQAASVQEQLQRVQQLRDQQQKKKQQIETEREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKTMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNASKLSALLFKHKEQLKAEILRKRALLDKELQIQVQEELKRDLKMKREREMAQAVQANAASVPTPSVPAPVPAPAPAAPPAPPRSPPPSTHSLPPAGHPTAPLPVTSQKRKREEEKDSKSKKKKMISTTSKEAKKDTRLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEADLIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERIQKRYYEKLTEFVADMTKIFDNCRYYNPRDTPFYQCAEVLESFFVQKLKGFKASRSHNNKLQSTAP
Protein: Uncharacterized peptidase C18A7.01 (EC 3.4.-.-) (Q9UUD8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- DNA-dependent metalloprotease WSS1 homolog
- DNA-dependent metalloprotease WSS1 homolog 2
- Probable delta-1-pyrroline-5-carboxylate dehydrogenase
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS3
Sequence:
MVSFESSFERGTDFLNRNFKKCLFACISIFIFALLALSFLSLLQPDTVQRLYQCAVPSMIYVPPMINEAISIQHEEFNNRRRRLSAALREDKLDALIMEPTVSMDYFANITTGSWGLSERPFLGIIFSDDEPYPGDVASRIYFLVPKFELPRAKELVGKNIDAKYITWDEDENPYQVLYDRLGPLKLMIDGTVRNFIAQGLQYAGFTTFGVSPRVASLREIKSPAEVDIMSRVNIATVAAIRSVQPCIKPGITEKELAEVINMLFVYGGLPVQESPIVLFGERAAMPHGGPSNRRLKKSEFVLMDVGTTLFGYHSDCTRTVLPHGQKMTERMEKLWNLVYDAQTAGIQMLSHLSNTSCAEVDLAARKVIKDAGYGEYFIHRLGHGLGLEEHEQTYLNPANKGTPVQKGNVFTVEPGIYIPDEIGIRIEDAVLASDVPILLTNFRAKSPYEP
Protein: Cytochrome b5 (Q93315)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004131}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004131}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004131}. Microsome membrane {ECO:0000256|ARBA:ARBA00037877}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037877}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037877}.
Interaction partners:
- NADH-cytochrome b5 reductase
- NADH-cytochrome b5 reductase
- Stress-associated endoplasmic reticulum protein 2
- Cytochrome-b5 reductase
- Cytochrome b5 heme-binding domain-containing protein
- Serpentine Receptor, class T
- sulfite oxidase
- Acyl carrier protein
- NADPH--cytochrome P450 reductase
- Protein transport protein Sec61 subunit beta
Sequence:
MADLKQITLKEIAEHNTNKSAWLVIGNKVFDVTKFLDEHPGGCEVLLEQAGSDGTEAFEDVGHSTDARHMKDEYLIGEVVASERKTYSYDKKQWKSTTEQDNKQRGGESMQTDNIVYFALLAVIVALVYYLIAA
Protein: Coiled-coil domain containing 24 (E9Q214)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPGDSPALWELVEEHVPLPERPEVKRILGEAAVDLSLELREEVAMLKALLQEIQSSQVSNSDPPSLLAPPPLLRDLIRQELRQLLQGLRLKAISEGRDQTQMWAQYSPRVLRFALEDTRCDSTQQELPMRADEPRAGMNNTERVMVTSPVSTCPRDLTVIKDQLNVSNIDQVVRHLRSLLEEECHML
Protein: Phosphatidylinositol 4-phosphate 5-kinase 6 (AtPIP5K6) (EC 2.7.1.68) (1-phosphatidylinositol 4-phosphate kinase 6) (Diphosphoinositide kinase 6) (PtdIns(4)P-5-kinase 6) (Q9SFB8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Phosphatidylinositol 4-kinase beta 1
- Phosphatidylinositol 4-kinase beta 2
- Phosphatidylinositol 4-kinase alpha 1
- Phosphatidylinositol 4-kinase alpha 2
- CRIB domain-containing protein RIC5
- Phosphoinositide phospholipase C 2
- Phosphoinositide phospholipase C 3
- CRIB domain-containing protein RIC3
- Phosphoinositide phospholipase C 5
- Phosphoinositide phospholipase C 7
Sequence:
MSVAHADDADDYSRPTGESYHAEKALPSGDFYTGQWRDNLPHGHGKYLWTDGCMYVGDWHRGKTMGKGRFSWPSGATYEGDFKNGYMDGKGTYIDSSGDLYRGSWVMNLRHGQGTKSYVNGDCYDGEWRRGLQDGHGRYQWKNENHYIGQWKNGLMNGNGTMIWSNGNRYDGSWEDGAPKGNGTFRWSDGSFYVGVWSKDPKEQNGTYYPSTSSGNFDWQPQQVFYVDLSECVVCTCQRIPVLPSQKMPVWYGASEQSSSGNRTKNSERPRRRSVDGRVSNGEMELRSNGSGYLQVDDNAESTRSSLGPLRIQPAKKQGQTISKGHKNYELMLNLQLGIRHSVGRPAPATSLDLKASAFDPKEKLWTKFPSEGSKYTPPHQSCEFKWKDYCPVVFRTLRKLFSVDAADYMLSICGNDALRELSSPGKSGSFFYLTNDDRYMIKTMKKAETKVLIRMLPAYYNHVRACENTLVTKFFGLHCVKLTGTAQKKVRFVIMGNLFCTGHSIHRRFDLKGSSHGRLTTKPESEIDPNTTLKDLDLNFAFRLQKNWFQEFCRQVDRDCEFLEQERIMDYSLLVGLHFREAAIKDSATPTSGARTPTGNSETRLSRAEMDRFLLDASKLASIKLGINMPARVERTARRSDCENQLVGDPTGEFYDVIVYFGIIDILQDYDISKKLEHAYKSMQYDPTSISAVDPKQYSRRFRDFIFRVFVEDA
Protein: GDP-L-fucose synthase 1 (EC 1.1.1.271) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase 1) (AtFX) (AtGER1) (O49213)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Not involved in the synthesis of GDP-L-galactose from GDP-D-manose.
Interaction partners:
- GDP-mannose 4,6 dehydratase 2
- GDP-mannose 4,6 dehydratase 1
- Putative GDP-L-fucose synthase 2
- Bifunctional fucokinase/GDP-fucose pyrophosphorylase
- Bifunctional dTDP-4-dehydrorhamnose 3,5-epimerase/dTDP-4-dehydrorhamnose reductase
- Probable mannose-1-phosphate guanylyltransferase 2
- ADP-glucose pyrophosphorylase family protein
- ADP-glucose pyrophosphorylase family protein
- Probable mannose-1-phosphate guanylyltransferase 3
Sequence:
MAETIGSEVSSMSDKSAKIFVAGHRGLVGSAIVRKLQEQGFTNLVLKTHAELDLTRQADVESFFSQEKPVYVILAAAKVGGIHANNTYPADFIGVNLQIQTNVIHSAYEHGVKKLLFLGSSCIYPKFAPQPIPESALLTASLEPTNEWYAIAKIAGIKTCQAYRIQHGWDAISGMPTNLYGPNDNFHPENSHVLPALMRRFHEAKVNGAEEVVVWGTGSPLREFLHVDDLADACVFLLDRYSGLEHVNIGSGQEVTIRELAELVKEVVGFEGKLGWDCTKPDGTPRKLMDSSKLASLGWTPKVSLRDGLSQTYDWYLKNVCNR
Protein: DNA ligase, putative (EC 6.5.1.1) (D6XJX8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- KU80 protein
- DNA ligase
- KU70 protein
- DNA ligase, putative
- Proliferating cell nuclear antigen
- Protein artemis
- Inhibitor of apoptosis-promoting Bax1
- RNA-editing ligase 1, mitochondrial
- Mitochondrial inner membrane signal peptidase, putative
- Exonuclease, putative
Sequence:
MWRISNLWRRPQLTTLPKDPSLFFGVGRPRTPEQVERYHAMKNTTIESAFPHLAACWVGPSWGTVMLTPHHVAPTCVKSAVWRCSQCLQEFEMSIARFIDQHGTCPLCGKEQRRISSTRNEGPERINGKMSEGDNTDVGITTSPTDATNEEDLELEDVNSLRAPRMTHTNYKSVLHSNPEWEGRNILPMLAQRWELVAEELLHPADTEEQESLLVSPKIDGIRCLIGYNKSQKKLQFFSRSGILLECCHGLVPHAMPLFKADPSLLLDGELFAPHCGFERLSGLVRRLEKFTTQTTRRKQAKLLEYFAFDIMASDQLSSPDAPFSERYRLLKELIPHSGADRVFDTMKPNGRRNHQLEKEELSSRKKIPKLYHVPATLVSPDEVESVLEKACSQGYEGVIIRRPKFPYEHGKRSLGLLKYKYMHDAEYRIVDFLPGNGKFEGGLGAFVCETSTGIRFNATPKTTTKRRLELWAERDRLLGKYLTVQYQELSSQDVPRFPIAKCVRGESEKDWL
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Q8QHI0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MAMKAVCVLKGTGEVTGTVFFEQEGADGPVKLIGEISGLAPGEHGFHVHAYGDNTNGCMSAGPHFNPHNQTHGGPTDAVRHVGDLGNVTAGADNVAKINIQDKMLTLTGPDSIIGRTMVIHEKADDLGKGGNEESLKTGNAGGRQACGVIGIAQ
Protein: Glutaredoxin domain-containing cysteine-rich protein 1 (A8MXD5)
Organism: Homo sapiens (Human)
Function: May play a role in actin filament architecture in developing stereocilia of sensory cells.
Subcellular location: Cell projection, stereocilium {ECO:0000250}. Cell projection, microvillus {ECO:0000250}. Cell projection, kinocilium {ECO:0000250}. Note=In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia. {ECO:0000250}.
Interaction partners:
- Taperin
- Phospholipid-transporting ATPase IA
- Unconventional myosin-VIIa
- Serine incorporator 3
- Myosin-9
- Rho family-interacting cell polarization regulator 2
- Glutaredoxin domain-containing cysteine-rich protein 2
- Glutaredoxin-1
- Fascin-2
- Adenylyl cyclase-associated protein 2
Sequence:
MLKREMKPESDRPRKVRFRIASSHSGRVLKEVYEDGQPSGSLDSECASICGIDGLGDSDGQQNGHIESEGDENENDQDSLLVLARAASEKGFGTRRVNILSKNGTVRGVKYKVSAGQALFNNLTKVLQQPSTDLEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGEYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDILTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSMFRNCFTDSFKALKCTACNENGLQRCKNCAG
Protein: Mitochondrial carrier protein, putative (Q587G5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSSEHAPVVASRKTSFRATAAGIAGVMEIGLFHPFDTVAKRLMSHHGPILCRPISASFCTVNEIIFRAKAHASAWEKLLYLYPGSTYAVGYKVLQRVYKLAGQPIVRDHLKCHYDRGFDNVFGRHSRLAMEAVAGSIVGGGEVLLLPLDRLKVLSQTNESALGRGVVELVRREGVRGMYAGTLVTAMRNVPGTFCLFGGAAFTKESIFRLEDFSKASFFQNMCASGVGACLAIAVTNPMDVIKTRVQNKDPGSTLTGLVVFRKLLREEGLTALAKGITPKIIASAPKLVFAYSMTEFLLQLLEGEKRGVVRH
Protein: Hypersensitive-induced response protein 4 (AtHIR4) (Q9FHM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000305|PubMed:17644812, ECO:0000305|Ref.6}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:17644812, ECO:0000305|Ref.6}.
Interaction partners:
- Prohibitin-5, mitochondrial
- Flotillin-like protein 3
- Prohibitin-4, mitochondrial
- Flotillin-like protein 2
- Prohibitin-7, mitochondrial
- Prohibitin-2, mitochondrial
- Flotillin-like protein 1
- Prohibitin-1, mitochondrial
- Prohibitin-6, mitochondrial
- NDR1/HIN1-like protein 3
Sequence:
MGNTYCILGGCIEQASVGVVERWGRFEHIAEPGCHFFNPLAGQWLAGVLSTRIKSLDVKIETKTKDNVFVQLVCSIQYRVVKASADDAFYELQNPKEQIQAYVFDVVRALVPMMTLDALFEQKGEVAKSVLEELEKVMGAYGYSIEHILMVDIIPDPSVRKAMNEINAAQRLQLASVYKGEAEKILQVKRAEAEAEAKYLGGVGVARQRQAITDGLRENILNFSDKVEGTSAKEVMDLIMITQYFDTIRDLGNSSKNTTVFLPHGPGHVRDISDQIRNGMMEAAASTQVNDV
Protein: SCP domain-containing protein (Q2PDZ4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- HDC01001
- trypsin
- RT03039p
- Seminal fluid protein 24F
- IP08087p
- FI16633p1
- Uncharacterized protein
- Prolyl 4-hydroxylase alpha subunit domain-containing protein
- Sulfhydryl oxidase
- DUF229 domain containing protein
Sequence:
MWSGPCVATGLLLLFGLNLVFLLPETNYCHLKNCPADKKLPHIGCNNSGSWSPKCGKDPKIIDVPKHIKKLILNHHNTYRDIVAGGQMHRLPIAARMLKLKWDHELALLATILVKRCDLQPTDHCISTEEFSSPSYHAVYNKFKAKEDTFRIVRSQLNAWYDQYKHVSSSSLIDGLSTAKKEIGHFLRMIVGPSNRLGCAIASIEKGGWTHQWLACLYSCSPQKNSLLYEYSGKPGVYCTTGINGKFQNLCNDTEPVKDCMHSELFQTITANDTTSLIRSMLNRQTQPRTFGWLWNWGKKIWGWVKNAWNAIVGCGKGGGGGGGDGGGGGGGDDGGEGDDGGDGGGGGDY
Protein: CG9437 protein (CG9437-PA) (Hinge1) (RT10665p) (RT11847p) (Q9W2K3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00371}.
Interaction partners:
- Hinge2
Sequence:
MSSNHRPLDDSDILLIQTIRETPSLYDPQLPSFRLSQRKEEDWAKVADLLNISISDARRRWTCLRDRYSRELKQKRLHPSGEFGHNDFFRKMDFLRDFVRKRRERRGRERDREQKPTGWMKVDLQRRRRTRLPIDTETLIEEQGSHAYDEGEEQHDYDAKLESHTTQSETYSVVVEADDGQEPEQESFDEFLGDAECEQKVKVVTIHPEIAAPNATSAPEPIESNHADLNYLVCMPPNANQEREHSAPELPNPTAVITQKTCETEDDFFCKSIAAYLRQLSRVHKIKAKVEMYQILEKYILLEECGKGSGAGGSG
Protein: Metacaspase-2 (EC 3.4.22.-) (PfMCA2) (Q8IL84)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Protease that cleaves specifically after arginine or lysine residues. May play a role in parasite growth and/or development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29317266}.
Interaction partners:
Sequence:
MNSMNTYSPLYSSYENINIYKKNRKFEEDNYETSTANISCDSKGRILVKESENDRNESIQKKQMLSSMDNRKTNKSEKHNISSYYKMRKKASNHLKDKEKLNNNIIYAKNPHANRYDKYYSLNMNIMNNMNNMNNMNNVNNMNNVNNMNNVNNMNNMNNVNNMNNMNNVNNMNNVKSMYNNNNNSNVYYRISRQNINGKERLLNRYNIMRPQRSADMLIRNYLYNDLPYEINQQNLNKNINDNNAGSFDNLNKTVFENYNKNILDEYNRNIMQYYNSNLKNYRNSSFDNIYTRYNNNNNNNNVYSNNNVYSNNNIYNNNNNNDNINNSFQFSKQEGLMKIYSNNNRNMNDYVVKTSNITRAADNTCAQEQINIPTYNKTVLLKSSPNTENTFNKTLSNILKEQPKRSSMFSFNSSDFFKDFGKLRKNFVGKKKNKINKDIVINGNIFNNKIIDNNTSNAKSEGNSTLHKIYNFIFPSSVKKLQKKKQKLQVIEDKEKNSNRAVVMPLKNKIIYINDANITNDKFKHSFENYNYHQTNIPFVSVTNYMNKDSTKNVRSFSSFDVKERISPRVIRNGNINNNKNNNINNNNNNINNNNNNINNNNNNINNNNNINNNNNINNNNNINNNNNINNNNINNINNINNDFVNDSNINKTVNIHNNNNNLNNYSNTMKSVAKNTQKLSAQKNSLVNDKHHTYHEKLITNIYQFTGGQSQKSCNIKNQNVKEEKINNTQISYINNTAYNDYTNLPNVETYVLSEKSNNLENKEDNNINEKFKNDNNVDKKNNDENNIIKHNVNQNNNEVIVMNNQTEEQINDNKFIKPLNNITGIDPKKKNIYNTVMHINDKMDLNKHDYNYNYNNIIPHNYINSSDKMTNNSLHINKKADDIFQNMISNNDTNVPCVYVNKYINNIFQNNNPSNVTNYINTINMNKAPITIDENSNKLDNNINYENVTKNMIYNNYTNNNVLYITKEKSDNKLNNSTNHLNDLKNNYYVINPSLLYIHNNNNNIEWNKQYTNNFSKPNFLDKFFYEKKVESIQPHHLNQYYYNNQNVKYNPSHINILENKYVNQFTNQNENSLYNFTTHHNNIKNNNIDNILLLDKAIRNQSIYYNNNKGDDETKSAEHTTNPSINLLKNNYEDKNKSNYVHSIVSITDKDNSIYAKNKYAEVVTKNNEKREDAIHKKDEQYIFNNNDNNNDNIHNNNIHNNIHNNIHNNIHNNIHNNIHNNIHNNIHNNIHNNIHNNIHNNIDVSSRENFFQHDIQNTNQINNKTILDITQNEKPNATNEKCLDINNKEKKKKKIKSVHYDMDEILSLKCKVYDELDTCLKCINNLTKNKKLYEQLKKYKHKLDKDTKTKKLYDECTSEKTGSYYTMKDSYISSLLCNEYKLNHILNKSNNKVSDDKHILSYNHHHNKNNNINDINNIKHISKFVNKDNEKTLNNINILNHNNKDPNSGVFLPSDNTESVIYNMNRNRKLCDNNFNVSKHVLYKDSKGTDSTRTNFYDDYSMSYVKSNVDNVEKKEKIKNNINISDKYFLSETDSPYIGKKKALMITLNYNGLLEGCVNDTVDMCDHLMQRFGFNDFILLNDCNLCYRNFVTQKANKKNILSNLHNFIVNSNNGDILFFYFCGYSIKLIDSKFTENYNFALLPQDHSKNNYIYSNEIFNIIKKLQGGKQLCIIFDTTYTSYFVPVPTSITYNKNMNTTEIYKYNNFSSNQKYLKSLKTFGKIRDRNVDSIFVENIKKPLLYEIYKKENDTNTNDKIILVPSIFFFSPDCNDRNDFEFSIKNKVRGLLTYCLGKAIELLKNDFSYHDLFVAASQILIDIKKEYNLKYVKFKLSFLNEYSPDDIKFLSHESLFLKKKLQLDEPLWKPSLKLNNLNQYIQDICNMDERKMLKSSKKKCLLIFIKDIKFYTYKNIDTKNEYFVSCFIKNKNVNILCVRRNNTKEQRIVQDKIFFLEYITLNVTHMENANIYVELFKKKKKNYFVARSIFNIRNVNGKFSLSDEKKNIIGIIDLNIKCVS
Protein: Ancillary SecYEG translocon subunit (Periplasmic chaperone YfgM) (P76576)
Organism: Escherichia coli (strain K12)
Function: May mediate protein transfer from the SecYEG translocon to the periplasmic chaperone network via its periplasmic C-terminal region. In addition, at the cytosolic site, acts as a negative regulator of RcsB. In stationary phase, the FtsH-dependent degradation of YfgM ensures the release of RcsB from YfgM and thereby permits cellular protection by the Rcs phosphorelay system. May coordinate stress responses across the inner membrane via a dynamic protein-protein interaction network inside and outside of the membrane.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:21210718}; Single-pass type II membrane protein {ECO:0000269|PubMed:21210718}; Periplasmic side {ECO:0000269|PubMed:21210718}.
Interaction partners:
- Outer membrane protein assembly factor BamB
- Histidine--tRNA ligase
- Periplasmic chaperone PpiD
- Protein translocase subunit SecE
- Outer membrane protein assembly factor BamC
- UPF0149 protein YgfB
- Transcriptional regulatory protein RcsB
- Cytoskeleton protein RodZ
- Rod shape-determining protein MreD
- Chaperone SurA
Sequence:
MEIYENENDQVEAVKRFFAENGKALAVGVILGVGALIGWRYWNSHQVDSARSASLAYQNAVTAVSEGKPDSIPAAEKFAAENKNTYGALASLELAQQFVDKNELEKAAAQLQQGLADTSDENLKAVINLRLARVQVQLKQADAALKTLDTIKGEGWAAIVADLRGEALLSKGDKQGARSAWEAGVKSDVTPALSEMMQMKINNLSI
Protein: Carbon storage regulator (Translational dual regulator CsrA) (P69913)
Organism: Escherichia coli (strain K12)
Function: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability, initially identified for its effects on central carbon metabolism. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Binds to the 5'-UTR of mRNA to repress or activate translation; 2 binding sites on the homodimer can bridge 2 sites within target RNA (By similarity). Exerts reciprocal effects on enzymes of gluconeogenesis and glycogen biosynthesis versus those of glycolysis. Negatively effects glycogen biosynthesis, gluconeogenesis, alters cell size and surface properties. Activates regulates expression of glycolysis genes. Represses biofilm formation. Regulates glycogen synthesis under both aerobic and anaerobic conditions; overexpression strongly inhibits glycogen accumulation. Binds to 4 sites in its own promoter, including the Shine-Dalgarno sequence, repressing its own translation; mutating the binding-sites decreases repression. Indirectly activates transcription from 1 of its 5 promoters, which is responsible for increased expression during stationary phase. Binds to at least 720 transcripts in strain K12 / CF7789, many of which are also part of the stringent response, including relA, spoT and dksA; slightly represses RelA and slightly activates DskA translation. Binds to and represses the ECF sigma factor rpoE promoter. Accelerates the degradation of glgC gene transcripts; overexpression further decreases glgC transcripts. Binds 2 sites in the glgC mRNA leader, 1 of which overlaps the Shine-Dalgarno sequence, preventing ribosome-binding and thus destabilizing the mRNA. Acts to inhibit interaction between the CcdB (also known as LetD) protein and the A subunit of DNA gyrase. Required to activate motility and flagellum biosynthesis through the post-transcriptional activation of flhDC expression by binding to and stabilizing the flhDC message. Represses translation of iraD mRNA via translational coupling to an upstream open reading frame. Binds to mRNA and reduces levels of probable diguanylate cyclases dgcT and dgcZ.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00167}.
Interaction partners:
- RNA-binding protein Hfq
- Signal transduction histidine-protein kinase BarA
- Ribosomal RNA small subunit methyltransferase A
- Flagellin
- Glucose-1-phosphate adenylyltransferase
- Ribonuclease E
- Response regulator UvrY
- RNase E specificity factor CsrD
- Poly-beta-1,6-N-acetyl-D-glucosamine export protein
- RNA polymerase sigma factor RpoS
Sequence:
MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKSQQSSY
Protein: Uncharacterized protein C17D1.07c (Q10201)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Cell division control protein 42 homolog
- Meiotic expression up-regulated protein 14
- Sporulation-specific protein 3
- Ras GTPase-activating-like protein rng2
Sequence:
MKMLQNKGPLQELTLNAMAPNGIFQDEPMIQKFENHYVFKKDMKSKRNKEVKNQMNDWLAYGYLCSVHEAKKWLEEETNNEYQNLDDFVDALVNGKVLCQLAFKYYPKLASNWKPRYQISERNTVYLNAFFHFLDFIGMFTPFRFETKDLVRRFNIPKVIYCLHALSYLLDFLEVTRHVPSLYGKLRIKKSQLNTATKEISLLKKAKKFPNFPKLKNFFCSYSHRHETATSNKQVSCFREVPAWIKQCQSQCRGFLTRKCVSIEKLRRDDMSERLGWLPKLETKLSSISDEERLILLKESHQIYRKMVSLHLELLHLPQLEMSLDFCGFSSDDSSIAISSQLVPPILNNLIFKLEESPQIWILIISRFSSDGIDKIDVQNFILLILKFFGFAISASDRRSFLNLIMSCVMVSIQQSSAEVGHSTSDSLISWASRLFTKGFCLQLQSFFEKHLGNVVDKFFLEHLCETTIESDAMRVVTEMLVSCYENRERIPNELPMVLKQIYYSRSESFKPSAIKEFIEYFLCDQLMNCLSVYYSKYFEGKDSKKFTLVKHFMNSLFGRVKLNEQTEIIWHTRNYRIVEALVRKLIHLSTPKIIPVYGGRTLSCTHKDIFDLQNILRYCDERGDFSSFPSFKKLISLLGSPKLFKKHENQILLLESKNEVIHSSLPCSKSSLYQLSLSLCIPLIEGHLRNSLEEILFGVPTELENQKFMSVLRNDKLIKSIHPGSLSGISNSFVNSKHPIEQWQSRLRKILHLFSGRNEDIASLQCVLQFGSSERIHLEDIQNSHRYLCSLKKNNSQKDIHRNPLLSHVFDTNTKSFDTLKTLNYKHAILKKSMGELYKMEMIHECPRQLFGQILVVYLNRERTLLNFYLIENSKTIDEATLQLTDLIQAIKTGIYYLRMFNLPFHVKQLYTWLAPISKYDSEISFNQKKERRKTFLSFERRGKNRKF
Protein: Dehydrogenase/reductase SDR family member 1 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 19C member 1) (Protein SDR19C1) (Q96LJ7)
Organism: Homo sapiens (Human)
Function: NADPH-dependent oxidoreductase which catalyzes the reduction of steroids (estrone, androstene-3,17-dione and cortisone) as well as prostaglandin E1, isatin and xenobiotics in vitro. May have a role in steroid and/or xenobiotic metabolism.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:30031147}. Note=May be attached to the ER membrane by its C-terminus segment. {ECO:0000269|PubMed:30031147}.
Interaction partners:
Sequence:
MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLRVPKWIIALYTSKF
Protein: Epidermal stripes and patches, isoform A (Epidermal stripes and patches, isoform B) (RE29477p) (Q9VC29)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Tartan, isoform B
- Zinc carboxypeptidase A 1
- Ventrally expressed gene D protein
Sequence:
MKSNPASDHVYFNDGFKCSTISISTNLTEPNGSSNSVGSQGSKEFILTEDGKKVKPTVSTLDCTRSWLQDCQRRTFNRKTLHKRLPILGWLPKYNSQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSCKDVPMGPSAIVALLTYQAAQGSWQKSVLLCLLSGIVELLMGLFGLGFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLGITAKGNTFVEIWTQVFHNIEHTRAGDTVLGLTCIVILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIMGYMLHTEEHGAPFRVVGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFANGKPVDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFYFIPRPTLAAIIISAVVFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAARPKLSTELLTTQSGVEYSMITPDRCLIFPSVDYVRNLVNKQSIRQNVPVVIDASHVYGADFTTATVIDSLISDFNQRGQLLFFYNLKPSICSIFEHVSAAQFVVYYQEQQLDELLKERNYVQKRLETA
Protein: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase (EC 2.7.7.18) (Q8IE38)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Glutamine-dependent NAD
- nicotinate phosphoribosyltransferase
- nicotinamidase
- Bifunctional dihydrofolate reductase-thymidylate synthase
Sequence:
MHKNICIYGGSFDPITYAHEMVLDKISNLNWIHEIWVVICRCRNDKSLTEFHHRHNMFTIIINNSSKIIKSKIFLKDLESHSEMTPTYDLLKTQKELHPNYTFYFGLGSDLICDIFSWDEGEKLVLENAFIIIERGHFKIDESILKKFPKYYLINIPKLSFINFISSSEARKFLTKENDINDIKKYIHPLTIDYIIKYNLYDFN
Protein: T. brucei spp.-specific protein (Q389X8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHVCILLLVLPFFMCVGFLFATICSAFLRGPSCGRRLPILVRTLLFSTSVSPLFKVFSTLSETLFTCIPGPKLIQIINRAMSSRNCSLSQGRLLSRQKRPLVVAQFLNKVPIEDRHAATNALLCLGLRAYKMVHATTPPDMQTLRSAVSAEISAVASGSEGLNDQKIDEGTASGRQRGAVDDVDAFLFARRERGQAPSSSPPVDRRLEGNTEEEEFYTRIESVRNVGEPSYHDRMPQLMEDVDVYSSSKSGADTRALNRLAGDGGESDRAAGKSGCFTDVLDFVTNCAVGSLSLCTPTRCREAANVSSSPPANCYNAPGSEQPNMGHASPLRASGSQDLPLGGMKEFNMNTVVPLLDDNGVVYPVEFIHHLMARIKSTRGVRENPILVAAYMPQSLAVYTLQGSFGDLYRSLLVSYHVSMW
Protein: Pregnancy specific beta-1-glycoprotein 16 (Pregnancy-specific glycoprotein) (D0VY58)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGQMYSGREIVSSNGSLWIHNVTRKDTGLYTLRTVNRRGEIVSTSFTFLYVYTSLFICGRPSFPAKLTIESVPPSVAEGGSVLLRVHNLQDKLRGLSWYKGAHVSRNLEIARQIIAKNSSVPGPAHSGRETVYSNGSLLLQNVTRNDTGFYTLQTLSRHRKMELAHVQLQVDTSLSSCCDTLDSTQLIIDPMPRYAAEGESILLRVLNLPEDFQVFCWYKGALIFQIFKIAEYSRARNSITKGPAQSRTERVYTNGSLLLQDVTEKDTGLYTLQTIDRNFKIEKAHVQIQVNKPVTQPFMRVTDSTVRVQSSVVFTCFSDNTGVSIHWLFNNQSLQLTERITLSPSKCQLRINPVRKEDGGEYQCEVFNLASSKSSLPVSLAVMNE