wanglab/gogpt-training-data huggingface dataset:
Protein: Cycloartenol Synthase (PgCAS) (EC 5.4.99.8) (Phytosterol synthase) (O82139)
Organism: Panax ginseng (Korean ginseng)
Function: Component of the phytosterols biosynthetic pathways (Probable). Oxidosqualene cyclase converting oxidosqualene to cycloartenol.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MWKLKIAEGGNPWLRTLNDHVGRQIWEFDPNIGSPEELAEVEKVRENFRNHRFEKKHSADLLMRIQFANENPGSVVLPQVKVNDGEDISEDKVTVTLKRAMSFYSTLQAHDGHWPGDYGGPMFLMPGLVITLSITGVLNVVLSKEHKREICRYLYNHQNRDGGWGLHIEGPSTMFGTVLNYVTLRLLGEGANDGQGAMEKGRQWILDHGSATAITSWGKMWLSVLGVFEWSGNNPLPPETWLLPYILPIHPGRMWCHRRMVYLPMSYLYGKRFVGPITPTVLSLRKEVFSVPYHEIDWNQARNLCAKEDLYYPHPLIQDILWASLDKVWEPIFMHWPAKKLREKSLRTVMEHIHYEDENTRYICIGPVNKVLNMLCCWVEDPNSEAFKLHLPRLHDFLWLAEDGMKMQGYNGSQLWDTAFAVQAIISTNLAEEYGPTLRKAHTFMKNSQVLDDCPGDLDAWYRHVSKGAWPFSTADHGWPISDCTAEGFKAVLQLSKLPSELVGEPLDAKRLYDAVNVILSLQNSDGGYATYELTRSYSWLELVNPAETFGDIVIDYPYVECTSAAIQALTAFKKLFPGHRREEIQHSIEKAALFIEKIQSSDGSWYGSWGVCFTYGTWFGIKGLVTAGRTFSSCASIRKACDFLLSKQVASGGWGESYLSCQNKVYTNLEGNRSHVVNTGWAMLALIDAGQAERDATPLHRAAKLLINSQMENGDFPQEEIMGVFDKNCMITYAAYRNIFPIWALGEYRCRVLQGPS
Protein: Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] (Q9BVT8)
Organism: Homo sapiens (Human)
Function: Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as negative regulator of hepatocyte growth during regeneration (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9JMG3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JMG3}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9JMG3}. Recycling endosome {ECO:0000250|UniProtKB:Q53AQ4}. Cytoplasm {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}.; SUBCELLULAR LOCATION: [iHOPS]: Cytoplasm {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Note=iHOPS is proposed to be the shuttling form across different cellular compartments. XPO1-dependent exported from the nucleus in dividing cells. Predominantly nuclear during growth arrest. {ECO:0000250|UniProtKB:Q9JMG3}.
Interaction partners:
- Erlin-2
- Membralin
- E3 ubiquitin-protein ligase RNF185
- Erlin-1
- Transmembrane and ubiquitin-like domain-containing protein 2
- E3 ubiquitin-protein ligase RNF170
- E3 ubiquitin-protein ligase AMFR
Sequence:
MTLIEGVGDEVTVLFSVLACLLVLALAWVSTHTAEGGDPLPQPSGTPTPSQPSAAMAATDSMRGEAPGAETPSLRHRGQAAQPEPSTGFTATPPAPDSPQEPLVLRLKFLNDSEQVARAWPHDTIGSLKRTQFPGREQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPNPPCPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP
Protein: Acyl carrier protein phosphodiesterase (ACP phosphodiesterase) (EC 3.1.4.14) (P21515)
Organism: Escherichia coli (strain K12)
Function: Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
Interaction partners:
- Pantothenate kinase
- Holo-[acyl-carrier-protein] synthase
- Phosphopantetheine adenylyltransferase
- 4'-phosphopantetheinyl transferase AcpT
- Coenzyme A biosynthesis bifunctional protein CoaBC
- Nucleoside triphosphate pyrophosphohydrolase
Sequence:
MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRSETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFVCYAREQVMTILPDSPPRFINLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQFYPRMMAQASRKAL
Protein: SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) (Q9NFP5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Multiplexin, isoform R
Sequence:
MVLKVYVSGMSGNKEVKKRQQRVLMILDSKNIKYDTVDITEPGKESEKELMQNKSTSNGGTVSDPEPRHPLPPQLFNDDEYCGDYDAFDMANEIDTLEVFLKLAPADTTAVSTAQIELKQENGDAKKEEAETEAEDKKTEAGDGDVDVKEEAAEKAEV
Protein: Tyrosine-protein kinase receptor (EC 2.7.10.1) (Q8CJH1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
DPESHKVICFCDHGTVLADDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFPGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPHPSKSNQEVLEFVTSGGRM
Protein: Protein YRO2 (P38079)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Protein YGP1
- Polyamine transporter 2
- Transcriptional activator HAA1
- Polyamine transporter 3
- Uncharacterized protein YBR053C
Sequence:
MSDYVELLKRGGNEAIKINPPTGADFHITSRGSDWLFTVFCVNLLFGVILVPLMFRKPVKDRFVYYTAIAPNLFMSIAYFTMASNLGWIPVRAKYNHVQTSTQKEHPGYRQIFYARYVGWFLAFPWPIIQMSLLGGTPLWQIAFNVGMTEIFTVCWLIAACVHSTYKWGYYTIGIGAAIVVCISLMTTTFNLVKARGKDVSNVFITFMSVIMFLWLIAYPTCFGITDGGNVLQPDSATIFYGIIDLLILSILPVLFMPLANYLGIERLGLIFDEEPAEHVGPVAEKKMPSPASFKSSDSDSSIKEKLKLKKKHKKDKKKAKKAKKAKKAKKAQEEEEDVATDSE
Protein: Solute carrier family 26 member 6, like 1 (Zgc:175226 protein) (A9JTH4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDSRHEEYHVKREVINEQRLKERSQRMNPSQINLPISHRLKTSLSCSVPRIKRSIVGFLPVLSWLPRYSIWDYGMPDLISGISVGIMHLPQGMAYALLASLPPVFGLYTSLYPSLIYFIFGTSRHISVGTFTILSIMIGSVTERLAPDTDFLIYNGTNVTGEVDIASRDLYRVQVAAAATVLGGLIQVVLGLVQFGFVGTYLSEPLVRGYTTAASAHAVVAQLKYILGVSPKRFNGPLSIVYTLVDLFTLLPETHLPTLVASVVSIVVLITAKELNNALKKKMIIPIPVELCTIVVATVISFYTRLNESYKISVVGDIPSGLQPPSVPNVYIFSEVVLDAFAMAIVGYAISISLGKTFALKHGYKVESNQELVALGLSNTVGGFFQCFSVCSSMSRSLIQESTGGKTQIAGVVSGVIVLVTVLKLGSLFQELPKAVLSAIVFVNLKGMFKQYYDIVTLWRSNKIDLLIWLVTFVSTVLFNLDMGLGASMGFALLTVIFRTQRPSYALLGHLPGTELYLDMETHKEVREVPGITIFRSSATMYFANAELYLEALKKKSGLDIGKMLTYKRRQEAKQKRRERRAERRARREAKRQKKAFREASQRSKHAVFSVEEEAGQLSDMNGDLHREAEIGWKERENNTVFVIPETARTSDGQHTWMYLKGTDPDTATLGSVSDLHDADVTTIDSSSEDTLSRDLERVSLGSLGKWTWDIHSIILDLSTANFIDTVAIKTLRNIFHDFGEIDVHIYMAGCQELVMKQLERGGFFSDVITEACVFATVHDAVLYCVKHHGAATINGHENALDMSGTRL
Protein: Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2) (O43155)
Organism: Homo sapiens (Human)
Function: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8BLU0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8BLU0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BLU0}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8BLU0}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q8BLU0}. Microsome membrane {ECO:0000250|UniProtKB:Q8BLU0}. Secreted {ECO:0000250|UniProtKB:Q8BLU0}. Synapse, synaptosome {ECO:0000250|UniProtKB:D3ZTV3}. Note=Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250|UniProtKB:Q8BLU0}.
Interaction partners:
- Netrin receptor UNC5D
- Adhesion G protein-coupled receptor L3
- Netrin receptor UNC5C
- Fibronectin
- Adhesion G protein-coupled receptor L1
- Netrin receptor UNC5A
- Adhesion G protein-coupled receptor L2
- Netrin receptor UNC5B
Sequence:
MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT
Protein: Peroxisomal ATPase PEX6 (EC 3.6.4.-) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Q99LC9)
Organism: Mus musculus (Mouse)
Function: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q13608}. Peroxisome membrane {ECO:0000250|UniProtKB:Q13608}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:26593283}. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes (By similarity). Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283). {ECO:0000250|UniProtKB:Q13608, ECO:0000269|PubMed:26593283}.
Interaction partners:
- Peroxisomal ATPase PEX1
- Peroxisome assembly protein 26
- Peroxisomal targeting signal 1 receptor
- Peroxisome biogenesis factor 10
- Peroxisomal membrane protein PEX14
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX13
- Peroxisomal targeting signal 2 receptor
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein PEX16
Sequence:
MALAVLRVLDPFPTETPPLAVLLPPGGPWPATGLGLVLALRPASESPAKPALLVAAVEGSGAQGEQRGPGPPPLLVSRALLRVLALGPGARVRARLVRRPPALGWALLATAPGPGLGPRVGPLLVRRGETLPVPGSRVLETRPALQGLLGPGTRLAVTELRGRAKLGQESRDHSHPPPPPVVSSFAASHSVRRLRGVLGGTGDALGVSRSCLRSLGLFQGEWVWVAQVAELPNSSQPRLAQVQVLEPRWELSERLGPNSGQQPGEPLADGLVFLPATLAFNLGCDPLEVGELRIQRYLEGSIAPENKGSCSPLPGPPFARELHIEILSSPHYSANGNYDHVLYRHFQTPRVVQEGDVLCVSTAGQVEILEGSLERLPRWREMFFKVKKTVGEAPEGPASAFLADTTHTSLYLAGTALSHVPSLPSGRSPPWDSLSPPGLEALVNELCAILKPHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVAATLRHLLLDEDALSRCPPLMVVATTSRVQDLPTDVQTAFPHELEVPVLSEAQRLSILQALTAHLPLGQEVNLPQLARRCAGFVVGDLYALLTHTCRAACTRIRASGSAGGLSEEDEGDLCVAGFPLLAEDFGQALDQLQTAHSQAVGAPRIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGASEDRASQLRVLSAITRKFKLEASVSLANVLDCCPPQLTGADLYSLCSDAMMTALKRRVRDLEEGLELRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC
Protein: Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) (Q59H18)
Organism: Homo sapiens (Human)
Function: May play a role in cardiac physiology.
Subcellular location: Nucleus {ECO:0000269|PubMed:12721663}. Cytoplasm {ECO:0000269|PubMed:12721663}. Note=Expressed at lower levels in the cytoplasm.
Interaction partners:
- Troponin I, cardiac muscle
- Serine/threonine-protein kinase TNNI3K
- Fucose-1-phosphate guanylyltransferase
- Protein transport protein Sec16B
Sequence:
MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
Protein: Polyketide synthase (F9XFI6)
Organism: Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
Interaction partners:
Sequence:
MASEHRSSKEFKQEPLAIVGLACRLPGHCNSPRDFLNLLQAGRIASIEVPKSRFNRDGFYAGPNQPGSIRSPGGMFIEDIDPKTFDATFFGINKQTAVAMDPQQRQLLEVVYEAMENAGIRLEDVNKKPIGCFVGSYAVDYGDIQGRDPADRAPGVTVGVGRAILSNRISYFLNTQGPSMTIDTACSGSLVGLDVAARYLSSGEIDGAIVAGANIYLSPEHAMDKGVINGAMSPTGKCHTFDARADGYIKAEAVNAVIVKRLSDALRDGDPVRAIIRGSATNNDGRTGGITAPSPEAQAVAIRAAYANAGITDFNATTYVECHGTGTQAGDPAEAQGVASVFAETRDPLHPLIIGSAKANIGHSEPAAGVTGLIKAILTLESDSIPGLPSLQTPNPQIDFEGLRLRVSRDAVPWPEVALRRVSVNSFGYGGSNVHLVLDAPNNEQRRLFQFSYEGNDTGRLLQQERGPSRPTLLVLSAHDEQAVRRNFLSLQKHLLNPSISTDLGSLSYTLSERRSRLFHRGFIVTDSSELDVGHLVTGKRRGKPPNIGFIFTGQGAQWPRQGKALLEYYPQAKKVILDLDDVLARLPHPPAWKLIDELTLSRTADEVQRPELSQALVTALQLALVHILKEWNVIPTAVLGHSSGEIAAAAATGIITNAQAITLAYYRGYAAERAAQVSGYGMLATGVGAVEVRPFLEGVEDGVEIACCNSPRSTTLSGRVEQLHTVQSRLEAAGLFARPLRVNVAYHSQFIKEVADDYRKLIAPIVSDEESQGERPIMYSSLTGRKRGLKVNADYWAKNMASVVRFDEALTELVQDTDASIDFLVEIGPSGALAGPVKQVLEQAQRHQEVSYTPAFARGKNAIRTLVECAGRAFIAGTDVDISRVNAIDSQHRPPVLVDLPNYSWDRSQEYWYENESSADWRHRLHPHHELLGSKVLGTSWQEPTWKNTLRVEDLPWLADHKATQSSSLGSEILFPATAFLAMAIEAIQQQHEGLTGVVPQTSIHGVRLRDIKFHRALPFQSESDVRIRLTLRPRTGDKSVWHEYNVASFVLERWQEHSSGLVRLAHAEEAAHAEGEEAHPLERPVPGDLWYKAMRDVGYKFGPSFRTQKAISAYPGQRRSRSLVSLREPALQRPASRYLIHPATFDGCIQSTAPAMWEGVRWDVNELLVPVSINDMFVSSHLTPSTDEARVEATADYSGVGRPESAKSHVYHISAHDTSSGQLVLQVSGLSHSIIDRSPSIYDKHRYSQVQWKPDITFERQAYPAGSLSLTDEYISLVLHKHSRLSVLEIVHTPDADQSLWLGGSSKFREAASDFTLAVSGFDELVKFQSKYPADATDGRFVVIERTTEALEAFALAQPESFQHDLVIYRSGLASDAELVQSARKYLKDGGYLLWSREQDTSSSEEHAGIDGHDDPVDSSHEEIAGGGNGIRRKANIEGLCPKDLRRIQLDIPRTLLREDVTLWADFSHSNSAGAGGNVKLCSLTRPDEAVRALLGGIAQAGWRMTHDGEPPAEVDSSAISLVIESGQPILPDISEKDWVSLQELLASGAPILWITEGSQMRPSQPHKALIHGLRRTAKAEDPLLELITLDVECINGPNTVPAVLDVLQRLKAGKLKGTGVDFEFAEREGVVYVPRVVPDTELNSAAAQRGRAGRSIPTTHRPLSSFDARVALHCEKPGDLDSLTWQEEDVVETLQPGTVEVEIMAVSLAFKDVAVAMGLVPENEHVLGLDGAGIVRRVASSGVVALRPGQRVVVSGHGVLANRVIKPACRVHELPAWMSFEQVATTPFITALHSLEGLAKLRKGSRVLVHSASGALGAAVIQLCQVAQAEVFATVGSAEKKEFLVREYGIPEDHIFSSRDTAFSHGIKKITGGRGVDIVLNSLTGELLEESWRCIAEGGTFIELGKRDLLDRGYLPLQPFLRNTSYRCIDFGHREMPDELIGETLKKAITLLEQGVLKPIEPVTVFRFDQISAAFRAMGGYHIGRVVVSRSAPPDVLIPVRPRARRLHLDPGAAYVLIGGLKGLNGGIAVQLALWGARTLVVLGRSGYDDDKSQAVLRELELLNTRVVLVQGDVARYEDVGRCLKAAGSPIRGIVHAAMVLRDRVFASMTNQEYHQALRSKVQGAWNLHRAAEELGISLDFFTLFSSISGLIGQKGQANYAAGNAFLDALAEHRKARGLPACSIDLGAIDDVGYMSEHVDLLRALDTDSWTPINQSLLHEILQFSIEQQDKEAPINPASSAQLVTSISHHQKPGGALLSDARFGALGRGYIGEDDDSADEIEAGGAAEVRAFKTLVQNGANTASLQQGAVAAIKAHLAKILQSTQPIEEERSLIDYGIDSLAGVELRNWIRSRFDVELSTLEVTQTPSLSALGSKVVKRKSSSEHDDERARKRVRKD
Protein: Meprin A subunit alpha (EC 3.4.24.18) (Endopeptidase-2) (Endopeptidase-24.18 subunit alpha) (E-24.18) (MEP-1) (Q64230)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Lysosomal Pro-X carboxypeptidase
- Xaa-Pro aminopeptidase 2
- Meprin A subunit beta
- Dipeptidyl peptidase 4
- Angiotensin-converting enzyme 2
- Neprilysin
Sequence:
MLWTLPVCLLSLSFSAHIAAVSIQHLSTGHDHDDVDVGEQQKDISEINSAAGLNLFQGDILLPRTRNALRDPSSRWKLPIPYILADNLDLNAKGAILNAFEMFRLKSCVDFKPYEGESSYIIFQQFSGCWSMVGDQHVGQNISIGEGCDYKAIIEHEILHALGFFHEQSRTDRDDYVNIWWNEIMTDYEHNFNTYDDKTITDLNTPYDYESLMHYGPFSFNKNETIPTITTKIPEFNAIIGQRLDFSATDLTRLNRMYNCTRTHTLLDHCAFEKTNICGMIQGTRDDADWVHEDSSQPGQVDHTLVGRCKAAGYFMYFNTSSGVTGEVALLESRILYPKRKQQCLQFFYKMTGSPADRLLIWVRRDDNTGNVCQLAKIQTFQGDSDHNWKIAHVTLNEEKKFRYVFQGTKGDPGNSDGGIYLDDITLTETPCPTGVWTIRNISQVLENTVKGDRLVSPRFYNSEGYGFGVTLYPNGRITSNSGYLGLAFHLYSGDNDVILEWPVENRQAIMTILDQEPDARNRMSLSLMFTTSKYQTSSAINGSVIWDRPTKVGVYDKDCDCFRSIDWGWGQAISHQMLMRRNFLKDDTLIIFVDFKDLTHLRQTEVPIPSRSVIPRGLLLQGQEPLALGDSRIAMMEESLPRRLDQRQPSRPKRSVENTGPMEDHNWPQYFRDPCDPNPCQNEGTCVNVKGMASCRCVSGHAFFYTGERCQAMHVHGSLLGLLIGCITALIFLTFITFSNTYQKLRQ
Protein: Phosphorelay intermediate protein YPD1 (Histidine-containing phosphotransfer protein YPD1) (Tyrosine phosphatase-dependent protein 1) (Q07688)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Phosphorelay intermediate protein that is part of the branched SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound osmosensing histidine kinase SLN1 to two distinct response regulator proteins, SSK1 in the cytoplasm, and transcription factor SKN7 in the nucleus.
Subcellular location: Cytoplasm. Nucleus. Note=Localizes constitutively to the cytoplasm and the nucleus, independent on osmotic conditions and phosphorylation status of the protein.
Interaction partners:
- Osmosensing histidine protein kinase SLN1
- Osmolarity two-component system protein SSK1
- Transcription factor SKN7
- Mitogen-activated protein kinase HOG1
- MAP kinase kinase PBS2
- MAP kinase kinase kinase SSK2
- Serine/threonine-protein kinase SSK22
- High osmolarity signaling protein SHO1
- Serine/threonine-protein kinase STE11
- Signaling mucin HKR1
Sequence:
MSTIPSEIINWTILNEIISMDDDDSDFSKGLIIQFIDQAQTTFAQMQRQLDGEKNLTELDNLGHFLKGSSAALGLQRIAWVCERIQNLGRKMEHFFPNKTELVNTLSDKSIINGINIDEDDEEIKIQVDDKDENSIYLILIAKALNQSRLEFKLARIELSKYYNTNL
Protein: Stevor (Q8I3D8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKMYNLKMLLFTFLINTLALPHYDNYQNSHYNINLIQYRAQRTTINSRLLAQTKNHNPHYHNDPELKEIIDKMNEEAIKKYQQTHDPYKQLKEVVEKNGTKYTGGNDAEPMSTLEKELLETYEEVFGNDNHMLKSGMHPNDDDISDTSSSCECTDIDNAKLAKTKGRDKYLKHLKGRCTRGIYFCSVGSALLTTIGVCATKAALIAKFAEVPKNCIYTISILDMLTYESMSSALKALSIQACASDLAGTAASAAMGIFYPCGIAALVLLILAVVLIILYIWLYRRRKNSWKHECKKHLCK
Protein: Stanniocalcin-1 (STC-1) (P52823)
Organism: Homo sapiens (Human)
Function: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MLQNSAVLLVLVISASATHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGVTSKVFLAIRRCSTFQRMIAEVQEECYSKLNVCSIAKRNPEAITEVVQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEEDSPSHIKRTSHESA
Protein: Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6) (Q92947)
Organism: Homo sapiens (Human)
Function: Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Enoyl-CoA hydratase, mitochondrial
- Peroxisomal bifunctional enzyme
- Trifunctional enzyme subunit alpha, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- 2-oxoadipate dehydrogenase complex component E1
- Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 1
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 3
Sequence:
MALRGVSVRLLSRGPGLHVLRTWVSSAAQTEKGGRTQSQLAKSSRPEFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTASK
Protein: Achromobactin-binding periplasmic protein (Q47084)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Function: Binds citrate- or chloride-dependent Fe(3+); part of the binding-protein-dependent transport system CbrABCD for uptake of the siderophore achromobactin.
Subcellular location: Periplasm.
Interaction partners:
- Achromobactin transport ATP-binding protein CbrD
- Achromobactin transport system permease protein CbrC
- Achromobactin transport system permease protein CbrB
- Ferrichrysobactin transporter, permease ATPase component
- Achromobactin siderophore NIS synthase
- TonB-dependent receptor
- Achromobactin siderophore NIS synthase
- ATP-binding component of iron-hydroxamate transporter
Sequence:
MNEYLVSRRRLLRLSLSLLPLGLGRPALAQSLFMPQRVITLFQGATDTAVALGITPAGVVDSWSEKPMYRYLRQALAGVPHVGLETQPSLEDIVLLKPDAIVASRFRHQRLEPLLSQIAPVVMLDEIYQFKKTVQVMGQALQRQAVADQLLQNWQLRVNGLREQLQRKFGGDWPPTVSILDIREDHIRSYLPGSFPGSVLSELGFGWSDASRAQPGVSLKLTNKESIPVVDADIFFIFLRSESPSVQRNYESLIRHPLWQQLRAPRRNQVWVVNGVTWSLSGGILGANMMLDDIARVTGIAGGVS
Protein: Inner membrane protein YjiG (P0AEH8)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized protein YjiH
- Isoaspartyl dipeptidase
- HTH-type transcriptional regulator YjiE
Sequence:
MTTQVRKNVMDMFIDGARRGFTIATTNLLPNVVMAFVIIQALKITGLLDWVGHICEPVMALWGLPGEAATVLLAALMSMGGAVGVAASLATAGALTGHDVTVLLPAMYLMGNPVQNVGRCLGTAEVNAKYYPHIITVCVINALLSIWVMQLIV
Protein: C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195) (P51681)
Organism: Homo sapiens (Human)
Function: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10383387, ECO:0000269|PubMed:11323418}; Multi-pass membrane protein {ECO:0000269|PubMed:11323418}.
Interaction partners:
- C-C motif chemokine 3-like 1
- C-C motif chemokine 8
- C-C motif chemokine 5
- Inter-alpha-trypsin inhibitor heavy chain H4
- T-cell surface glycoprotein CD4
- C-C motif chemokine 4
- C-C motif chemokine 2
- C-C motif chemokine 3
- C-X-C motif chemokine 10
- Eotaxin
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
Protein: Complement C1q and tumor necrosis factor-related protein 9B (C1q/TNF-related protein 9B) (CTRP9B) (Complement C1q and tumor necrosis factor-related protein 9-like) (B2RNN3)
Organism: Homo sapiens (Human)
Function: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.
Subcellular location: Secreted {ECO:0000269|PubMed:19666007}. Note=Heteromeric complex formation with CTRP9A or ADIPOQ is required for secretion, otherwise, it is retained in the endoplasmic reticulum.
Interaction partners:
- Complement C1q and tumor necrosis factor-related protein 9A
Sequence:
MRIWWLLLAIEICTGNINSQDTCRQGHPGIPGNPGHNGLPGRDGRDGAKGDKGDAGEPGCPGSPGKDGTSGEKGERGADGKVEAKGIKGDQGSRGSPGKHGPKGLAGPMGEKGLRGETGPQGQKGNKGDVGPTGPEGPRGNIGPLGPTGLPGPMGPIGKPGPKGEAGPTGPQGEPGVRGIRGWKGDRGEKGKIGETLVLPKSAFTVGLTVLSKFPSSDVPIKFDKILYNEFNHYDTAVGKFTCHIAGVYYFTYHITVFSRNVQVSLVKNGVKILHTRDAYVSSEDQASGSIVLQLKLGDEMWLQVTGGERFNGLFADEDDDTTFTGFLLFSSQ