wanglab/gogpt-training-data huggingface dataset:
Protein: Acetylcholine receptor subunit beta-type acr-3 (Q93149)
Organism: Caenorhabditis elegans
Function: Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q23022}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q23022}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acetylcholine receptor subunit alpha-type unc-38
- Acetylcholine receptor subunit alpha-type unc-63
- AcetylCholine Receptor
- Acetylcholine receptor subunit beta-type acr-2
Sequence:
MQKIWLFSIITIFLITELQCYPNSAEERLLSYIFDGYNSLIRPVLNASSPPIEVFFSLAFVLLINVDEKNQIMQTNVWPTMKWNDYQMQWDPREFDGIKTIRVPPDKVWLPDIVLFNNADGNYLVSFYSNVVVEHTGDMLWVPPAVYKSSCLIDVEFFPFDEQVCSLTFGSWTFRKDELQLSYLSGKRHVELNDYLPSGVWDLIDAPGLLIDERSKISYQIKIRRKALFYTVILIMPTVLMAFLSMMVFYLPAESSEKITLAISILLALVVFLLVVSKILPPTSSTIPLMAKYLLMTFIMNMITIMVSVIIINVYFRGPATHIMPNWVKTVFLKFLPVLFVMRRPESTEKELAKMKREKRERRSMKSALKTFFKRNDAKISEQPKQTSRKDGSSSEEKLSSDAKKAIEAIEYITTHLTHDNAFKRQREEWKFVSVVIDRLLLYLFFAVTTGGTVGILLSAPNVFEQVNQTSVIERLKQQAAEEMLNS
Protein: histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (A0A2R8Y6I1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRYREFCQCDFDIAGQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLNVGSVAAGGRYDGLVGMFDPKGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVRTTETQVFVATPQKNFLQERLKLIAELWDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIRSVASREEVAIKRENFVAEIQKRLSES
Protein: Secreted effector protein SptP [Includes: GTPase-activating protein (GAP); Tyrosine-protein phosphatase (EC 3.1.3.48)] (P74873)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear.
Subcellular location: Secreted {ECO:0000269|PubMed:10499590}. Host cytoplasm {ECO:0000269|PubMed:10499590}. Note=Secreted via type III secretion system 1 (SPI-1 T3SS), and delivered into the host cytoplasm.
Interaction partners:
- Chaperone protein SicP
- SPI-1 type 3 secretion system translocon protein SctB
- Cell invasion protein SipA
- SPI-1 type 3 secretion system translocon protein SctE
- Inositol phosphate phosphatase SopB
- SPI-1 type 3 secretion system secretin
- Cell invasion protein SipD
- Guanine nucleotide exchange factor sopE2
- Lipoprotein PrgK
- Chaperone protein SicA
Sequence:
MLKYEERKLNNLTLSSFSKVGVSNDARLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFKNTEVVQKHTENIRVQDQKILQTFLHALTEKYGETAVNDALLMSRINMNKPLTQRLAVQITECVKAADEGFINLIKSKDNVGVRNAALVIKGGDTKVAEKNNDVGAESKQPLLDIALKGLKRTLPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQNLNKIPEAKQLNDYVTTLTNIQVGVARFSQWGTCGGEVERWVDKASTHELTQAVKKIHVIAKELKNVTAELEKIEAGAPMPQTMSGPTLGLARFAVSSIPINQQTQVKLSDGMPVPVNTLTFDGKPVALAGSYPKNTPDALEAHMKMLLEKECSCLVVLTSEDQMQAKQLPPYFRGSYTFGEVHTNSQKVSSASQGEAIDQYNMQLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIHCLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRDSRNNRMLEDASQFVQLKAMQAQLLMTTAS
Protein: Cell adhesion molecule CEACAM16 (Carcinoembryonic antigen-related cell adhesion molecule 16) (CEA cell adhesion molecule 16) (E9QA28)
Organism: Mus musculus (Mouse)
Function: Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.
Subcellular location: Secreted {ECO:0000269|PubMed:21368133}. Note=Localizes at the tip of cochlear outer hair cells and to the tectorial membrane. {ECO:0000269|PubMed:21368133}.
Interaction partners:
- Alpha-tectorin
- Beta-tectorin
- Stereocilin
- CEA cell adhesion molecule 19
- Lipoxygenase homology domain-containing protein 1
- Thrombospondin-type laminin G domain and EAR repeat-containing protein
- Otogelin
- Otogelin-like protein
- Whirlin
- Espin
Sequence:
MKMPLTWYSWFLLSAWILNTGAEISITPEPAQPAEGDNVTLVVHGLSGELLAYNWYAGPTLSLTFLVASYIVSTGDETPGPAHTGREAVRPDGSLDIHGALPGHTGTYILQTLNRQFQTEVGYGHMQVYEILAPPTVMANDTALVERRDTLRLVCSSPSPAEVRWFFNGDALPVAVRLGMSPDGRMLTRHGVRREEAGAYQCEVWNPVSVSRSEPLNLTVYFGPERVAILQDSTTRTGCTIKVDFNMSLTLWCVARSCPEPEYVWAFNGKALKNGQDHLNISSMTAAHEGTYTCIAKNSKTLLSGSASVVVKLSAAAVAMMIVPVPTKPTEGQDVTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGNWIAGPAHTGREVGFANCSLLVQKLNLTDAGRYTLKTVTLQGKTDTLEVELQVAPLE
Protein: Maltase-glucoamylase (A0A0J9YVJ0)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
GAEKVKAYVPNATWYDYETGEELGWRKQSIEMQLPGDKIGLHLRGGYIFPTQQPATTTEASRKNPLGLIVALDENKEARGELFWDDGESKDTVAQNIYLFSEFSVTQNRLDVSTLQSTYMNPDNLAFQEIKIFGTRPLYNVTVKHNGMVNQMAPQVSYDPSMKVAVITGLQLLLNESYTVEWDDSIRDEEKIDCYPDQHGASETSCTARGCVWEESNSDVVPFCYFVNELYSVSNVQYGSHGATANISLKASPYSGAFPSTPVKELQLQVTYHKNEMLQFKIYDPNHSRYEVPVPLNIPSAPSSTPESRLYDVLIKENPFGIEIRRKGTGTVVWDSQLLGFTFSDMFIRISTRLPSTYIYGFGETEHTTFKIDMNWNKWGMFSRDEPPGYRKNSYGVHPYYMGLEEDGNAHGVLLMNSNAMDVTFQPMPALTYRTTGGILDFYVFLGPTPEFVTQQYTELIGRPVMVPYWSLGFQLCRYGYENDSEIASLYDEMVDKKIPYDVQYSDIDYMERQLDFKLSPKFSGFPALINRMKANGMRVILILDPAISGNETEPYPAFTRGVENDVFIRYPNNGSIVWGKVWPDYPNITVDPSLGWDHQVEQYRAYVAFPDFFRNSTATWWKKEIKELHSNTQDPAKSLKFDGLWIDMNEPSSFVNGAVPSGCSDATLNHPPYMPYLEARDRGLSSKTLCMESEQILPDGSRVRHYDVHNLYGWSQTRPTYEAVQEVTGERGIVITRSTFPSSGRWGGHWLGDNTAAWDQLGKSIIGMMDFSLFGISYTGSDICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWNKTFEDISRSVLETRYTLLPYLYTLMYKAHTEGSTVVRPLLHEFVSDRETWNIDKQFLLGPAFLVSPVLEPNARKVEAYFPRARWYDYYKGVDINATGEWKTLEAPLEYINLHIRGGYILPWQEPAMNTHLSRQKFMGLRAALNAEGRAEGWLFWDDGKRI
Protein: Histone H2A-alpha (H2A.1) (P04909)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H2B-alpha
- Histone H4
- DNA repair protein crb2
- Histone H2A-beta
- BRCT-containing protein 1
- Histone H2A.Z
- Histone H3.1/H3.2
- Histone H3.3
- Histone acetyltransferase mst1
- FACT complex subunit spt16
Sequence:
MSGGKSGGKAAVAKSAQSRSAKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVVPNINAHLLPKTSGRTGKPSQEL
Protein: ATP-sensitive inward rectifier potassium channel 10 (ATP-sensitive inward rectifier potassium channel KAB-2) (BIR10) (Brain-specific inwardly rectifying K(+) channel 1) (BIRK1) (Inward rectifier K(+) channel Kir4.1) (Potassium channel, inwardly rectifying subfamily J member 10) (P49655)
Organism: Rattus norvegicus (Rat)
Function: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P78508}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P78508}. Basolateral cell membrane {ECO:0000250|UniProtKB:P78508}. Note=In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16. {ECO:0000250|UniProtKB:P78508}.
Interaction partners:
- Inward rectifier potassium channel 16
- Aquaporin-4
- Dystrophin
- Caveolin-1
- Pendrin
- Excitatory amino acid transporter 2
- Excitatory amino acid transporter 1
- Disks large homolog 1
- Gap junction protein
Sequence:
MTSVAKVYYSQTTQTESRPLVAPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELGPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVAYHNGKLCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYVADFSLFDQVVKVASPGGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV
Protein: Inner membrane amino-acid ABC transporter permease protein YhdY (P45768)
Organism: Escherichia coli (strain K12)
Function: Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid; probably responsible for the translocation of the substrate across the membrane.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized amino-acid ABC transporter ATP-binding protein YhdZ
- Putative amino-acid ABC transporter permease protein YhdX
- L-cystine-binding protein TcyJ
- Glutamine-binding periplasmic protein
- Putative ABC transporter arginine-binding protein 2
- ABC transporter arginine-binding protein 1
- Glutamate/aspartate import ATP-binding protein GltL
- Lysine/arginine/ornithine-binding periplasmic protein
- Glutamine transport ATP-binding protein GlnQ
- L-cystine transport system ATP-binding protein TcyN
Sequence:
MTKVLLSHPPRPASHNSSRAMVWVRKNLFSSWSNSLLTIGCIWLMWELIPPLLNWAFLQANWVGSTRADCTKAGACWVFIHERFGQFMYGLYPHDQRWRINLALLIGLVSIAPMFWKILPHRGRYIAAWAVIYPLIVWWLMYGGFFALERVETRQWGGLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFMAEGTSIDKLIRALVGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLFSSVQQATVDPAWLGMSTEGYVFAALIYWIFCFSMSRYSQYLEKRFNTGRTPH
Protein: Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha) (Q9VAD4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
- Translation initiation factor eIF2B subunit gamma
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit epsilon
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 2 subunit 3
- Translation initiation factor eIF2B subunit delta
- Eukaryotic translation initiation factor 2 subunit 2
- non-specific serine/threonine protein kinase
- Eukaryotic translation elongation factor, selenocysteine-specific
- Guanine nucleotide exchange factor MSS4 homolog
Sequence:
MPQITENGQDFDVVKYFLQLLDEDKDLSSGIAAIRTLLMILEKKQFGTIHILHTTMREAVAAMRNTDLSIAAIVSAGELFCRFITLSLDDKHMEECRQIMLNRGKIFLTKLLNSRQVIAQQAQRFITDGCRILTHSRSRVVLKALITASQNKKSFHVYVTQGGTGNSGEEMVKDLHAAGIDCTLILDSATGYVMESVDFVLVGAEAVVESGGIINRIGTYTMGLCAREMKKPFYVLAESFKFSRLYPLNQRDLPNEYKYSRKHLNDVSKVHPLVDYTPPVYITLLFTDLGRLTPSAVSDELIKLYM
Protein: Growth hormone 2 (somatotropin-2) (B2Z9Z2)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
- Growth hormone receptor
- Growth hormone receptor isoform 1
- Growth hormone receptor-like isoform X1
- Somatolactin receptor
- Somatolactin
- Somatotropin
- Prolactin receptor
- Appetite-regulating hormone precursor
- Pro-opiomelanocortin A1
- Pro-opiomelanocortin A2
Sequence:
MGQVFLLMPVLLVSCFLSQGAAMENQRLFNIAVNRVQHLHLLAQKMFNDFEGTLLSDERRQLNKIFLLDFCNSDSIVSPIDKQETQKSSVLKLLHISFRLIESWEYPSQTLAISNSLMVRNSNQISEKLSDLKVGINLLIKGSQDGVLSLDDNDSQHLPPYGNYYQNLGGDGNIRRNYELLACFKKDMHKVETYLTVAKCRKSLEANCTL
Protein: Superoxide dismutase (EC 1.15.1.1) (F5GYZ5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
MFAFWPTHRRVAFQAWPQSLARRRTPPGEESTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQ
Protein: E3 ubiquitin-protein ligase ATL23 (EC 2.3.2.27) (RING-H2 finger protein ATL23) (RING-type E3 ubiquitin transferase ATL23) (Q8L9W3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8, UBC10, UBC11, UBC28 and UBC29 in vitro.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative actin-9
- 17.6 kDa class II heat shock protein
- 18.1 kDa class I heat shock protein
Sequence:
MHYTRISPALVPSLSPTAAAESSGGGTMIATVFMALLLPCVGMCIVFLIYLFLLWCSTRRRIERLRFAEPVKPVTGKGLSVLELEKIPKLTGRELAVIARSTECAVCLEDIESGQSTRLVPGCNHGFHQLCADTWLSNHTVCPVCRAELAPNLPQCNENQSPC
Protein: Receptor-type guanylate cyclase gcy-14 (EC 4.6.1.2) (Q23310)
Organism: Caenorhabditis elegans
Function: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Na(1+) and Li(1+) salt ions and alkaline pH in ASE left (ASEL) sensory neuron. Directly senses environmental alkalinity in ASEL neuron which probably leads to the activation of cGMP-gated cation channel tax2/tax4.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:23664973}. Note=Localizes in cilium of ASEL sensory neurons. {ECO:0000269|PubMed:23664973}.
Interaction partners:
- Bis
- Inosine triphosphate pyrophosphatase
- GTP cyclohydrolase 1
- Probable 3',5'-cyclic phosphodiesterase pde-5
- Probable 3',5'-cyclic phosphodiesterase pde-2
- Probable 3',5'-cyclic phosphodiesterase pde-3
Sequence:
MCLFLLLFPYLASGQFLQTVKVGLLFSKDTASVMRAVGYRTSAAAVLVARDRIRAEHLLDQYDFNFTVKFDECTEGLAGGKTVELINHDNVDVIIGPTCNRAGIAVASLAAYYNVPVFQWGLTTAADIGNVSRYPTTVTLSLDTHSMALGVREVLRRFEWDEFVFIYSNDGDEEKCASMKDDLEKMGIENSDVTLAYMVQIQTVTLDALQKALTEVSKRGRIIIACFANGRGFKKAFVASTVLAGMSTDEYMYMFAEPQSRGFYVDEINGGEHYSWDDTDGNFVTGLTPEQIRDAYGKVLYICDNMGLPTTITPEFANFSSQLISRMTEQPFNCVQDCSNSTYKVPATYAGQLFDAFYAYGVALNRSLTQDPTRANLKNGSFVLSDIGMSFQGVGGGTVTLDDTGTRIVQVYMFALNTSLLPYLAASLVINGSEVEYTPFYKSEADLWSVRPLARPICGFSGLECPPDFVKEYLVYTIIAAVIVVLALLAGCAGLLYTMQMKRKEMERQDLLWQVPFIELQQVQSKSKAEASMHSFASGPSTSTKITVESRSETINFIFYYYQQDILAAMKHDLILQFDAEQKAEFRQMRNFDNDNLNKFIGLCLDGPQLFSLWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISNGLLFIHNSFLKCHGHLTSRCCLIDDRWQIKISGYGLKSVRTFENPKKEDLLWTPPENLRNENEERLPEGDIYSFGIICSEILTRSSAFDLENRKEKPDVIIYQVKKGGHNPMRPSLDTGETVEINPALLHLIRDCWTERPSERPSIEQVRGHLNGMRDGRKSNLMDHVFNMLETYASTLEEEVSDRTKELVEEKKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNEHIRHIARMSLGFLSSLEFFRVQHLPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLTQVVGGFRTESRGEVIIKGKGVMETYWLLGEQSRISVSAQAPREKTPEPPRRQSVRSISPIIEKMSEETQKGLYSAYKDFNNGNECVS
Protein: Peptide methionine sulfoxide reductase 2 (EC 1.8.4.12) (P25566)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Methionine-R-sulfoxide reductase which catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. Protects iron-sulfur clusters from oxidative inactivation along with MXR1. Involved in the regulation of lifespan.
Interaction partners:
- Peptide methionine sulfoxide reductase
- Free methionine-R-sulfoxide reductase
- Guanine nucleotide-binding protein subunit beta 2
- GrpE protein homolog
- Glutathione peroxidase-like peroxiredoxin HYR1
Sequence:
MNKWSRLYVITVRRTFPGRRNIVLTQYWNKSKKMSDESNDVKWNDALTPLQLMVLRDKATERPNTGAYLHTNESGVYHCANCDRPLYSSKAKFDARCGWPAFYEEVSPGAITYHRDNSLMPARVEICCARCGGHLGHVFEGEGWKQLLNLPKDTRHCVNSASLNLKKD
Protein: Ferric enterobactin transport system permease protein FepD (P23876)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex FepBDGC involved in ferric enterobactin uptake. Responsible for the translocation of the substrate across the membrane (Probable).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:1479347, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ferric enterobactin transport ATP-binding protein FepC
- Ferric enterobactin transport system permease protein FepG
- Ferric enterobactin-binding periplasmic protein FepB
- Enterobactin exporter EntS
- Fe
- Iron
- Iron
- Vitamin B12-binding protein
- Ferrienterobactin receptor
- Iron
Sequence:
MSGSVAVTRAIAVPGLLLLLIIATALSLLIGAKSLPASVVLEAFSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAIVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRVIVPGELRVSVVSAFIGAPVLIFLVRRKTRGGA
Protein: Histamine-gated chloride channel subunit 1 (Q9VGI0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Histamine-gated chloride channel alpha1 subunit
- Histidine decarboxylase
Sequence:
MQSPTSKLVEFRCLIALAIYLHALEQSIQHCHCVHGYRNNTESAELVSHYESSLSLPDILPIPSKTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTEIELPQLDISNNYTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFMGPVATKAMKGYSDENISDLDDLKSALQHHRESIIEPQYDTFCHGHATAIYIDKFSRFFFPFSFFILNIVYWTTFL
Protein: Outer surface protein D (OspD) (H7C7Q2)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
Sequence:
MKKLIKILLLSLFLLLSISCVHDKQELSSKSNLNNQKGYLDNEGANSNYESKKQSILSELNQLLKQTTNSLKEAKNTTDNLNASNEANKVVEAVINAVNLISSAADQVKSATKNMHDLAQMAEIDLEKIKNSSDKAIFASNLAKEAYSLTKAAEQNMQKLYKEQQKISESESESDYSDSAEIKQAKEAVEIAWKATVEAKDKLIDVENTVKETLDKIKTETTNNTKLADIKEAAELVLQIAKNAKEIVQEVVALLNT
Protein: 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B) (P41595)
Organism: Homo sapiens (Human)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856}; Multi-pass membrane protein {ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q02152}.
Interaction partners:
- Guanine nucleotide-binding protein G
- 5-hydroxytryptamine receptor 2C
- 5-hydroxytryptamine receptor 2A
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Voltage-dependent L-type calcium channel subunit alpha-1F
- Tryptophan 5-hydroxylase 1
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
Protein: Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist) (Q15672)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Runt-related transcription factor 2
- Cellular tumor antigen p53
- Ras GTPase-activating protein-binding protein 2
- CD44 antigen
- Zinc finger protein SNAI2
- Twist-related protein 2
- Zinc finger E-box-binding homeobox 1
- Zinc finger protein SNAI1
- Homeobox protein MSX-2
- Transcription factor 12
Sequence:
MMQDVSSSPVSPADDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGGGVGGGDEPGSPAQGKRGKKSAGCGGGGGAGGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH
Protein: ADP-L-glycero-D-mannoheptose-6-epimerase (RfaD) (O25530)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- Bifunctional protein HldE
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS15
Sequence:
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVIILDKFRSNTLFSNKRPSSLGHFKNLIGFKGEVIAADINNPLDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIYASSAGVYGNTKAPNVVGSNESPENVYGFSKLCMDEFVLSHSNDNVQVGLRYFNVYGPREFYKEKTASMVLQLALGAMAFKEVKLFEFGEQLRDFVYIEDVIQASVKAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAILDLDYTPLYDLESGIKDYLPHIHAIFKGQCA