wanglab/gogpt-training-data huggingface dataset:
Protein: Small ribosomal subunit protein eS27w (40S ribosomal protein S27-3) (Q8L953)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS19x
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS21y
- Small ribosomal subunit protein eS21z
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein eS28x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS7y
Sequence:
MVLQNDIDLLHPPPELEKRKHKLKRLVQSPNSFFMDVKCQGCFNITTVFSHSQTVVVCGNCQTVLCQPTGGKARLQEGCSFRKK
Protein: La-related protein 1B (AtLARP1b) (Q8RWR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes leaf senescence.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Uncharacterized protein At2g23090
- UBP1-associated protein 2B
- UBP1-associated protein 2C
- UBP1-associated protein 2A
- La-related protein 6C
- Ubiquitin carboxyl-terminal hydrolase 1
- Ubiquitin-activating enzyme E1 2
Sequence:
MATTASSAANSASRFSIDSSISRSRHGDSSPWLLPSDSHDHPTLSLSQDDPFSAPSVSPPTGNNSSDYDNADKKPPPVWNMPSSNSSSDVGPVMGAAESWPALSLSARSSSIKSPSLDASKPFPDGSSSSIPPPQATSNTSTNANAGSSVSATSSENSAVNNSQRKPFRRNNNTSSSSTSSNVSNAAPLNTRDQNHSQRGGGSFGSGNFRNSQRNRNSSSYPRGEGLHHGNRRNYEHGNQSGFSHRNYSGRDMHLQPQRGVGMIRPQMLMGPPSFPASSAQYMAAPQLGSYGGPIIYPDYAQHVFMPHPSPDPMGLVGPFPLQPMYFRNFDAILYNKILTQVEYYFSADNLSRDEHLRDQMNDEGWVPVRVIAAFRRLAELTNNIQTILEALRSSEVVEIQGETLRRRGDWDKYLLPREPSRSGPAAGASNNASLVSQIESMTLSERSREGV
Protein: Creatine kinase B-type (EC 2.7.3.2) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase M-type) (CPK-B) (P05122)
Organism: Gallus gallus (Chicken)
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}. Cell membrane {ECO:0000250|UniProtKB:P12277}.
Interaction partners:
- RMT2 domain-containing protein.
- Creatine kinase U-type, mitochondrial
- Creatine kinase S-type, mitochondrial
- Phosphagen kinase C-terminal domain-containing protein
- Uncharacterized protein.
Sequence:
MPFSNSHNLLKMKYSVDDEYPDLSVHNNHMAKVLTLDLYKKLRDRQTSSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKELFDPVIEDRHGGYKPTDEHKTDLNADNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLSVEALGSLGGDLKGKYYALRNMTDAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPNLGKHEKFGEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEKRLEKGQSIDDLMPAQK
Protein: MGC163038 protein (A4QP88)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSEYSAVPPPGPGAALGAGGLKKDAFADAVQRARQIAAKIGGDVTGPPMSNNGGAESYPFPTPKRSLEDEDQPESKKMASDRDNAAALSIGAQLAALSKQSVRPSSMTEEYRVPDGMVGLIIGRGGEQINKIQQDSGCKVQIAPDSGGLPDRSVSITGGPEAIQKAKMMLDDIVSRGRGTPPSFHESTNGSGHMQEMVIPAGKAGLIIGKGGETIKQLQERAGVKMILIQDASQGPNMDKPLRIIGDPYKVQQAREMVQEILRERDHPGFERNEYGSRMGGGGGGGGGGGGGGGGIEVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKPDDGTGPDKIAHIMGPPDRCEHAASIINELLQSIRVREEGGGGPPGPPGTGMPPGGRGRGRGPGGNWGGPPGSEMTFSIPAHKCGLVIGRGGENVKAINQQTGAFVEISRQPPPNGDPNFKLFTIRGSPQQIDHAKQLIEDKIEGPLCPVGPGPGGPGPAGPMGPYNPNPYQPGPPGGPPHGGPPGGQYPQGWGNAYQQWQPHDPSKAATDPNAAWAAYYAQYYQQPGGAAMPGQTPAAQPAAPGPADQSQAAPGAAQPDYTKAWEEYYKKMAAAGGGAAPAAAGGAQPAGAAAAAGQTDYSAAWAEYYRQQAAYYGQTGQTPGQPGATPQGQQAQ
Protein: Bruno 3, isoform N (Bruno 3, isoform O) (M9PI52)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQLQQLPGQISHRKLMNRALQLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAFVKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNPFVFNQFSPYGAYAQQQQQAALMAAAATAPGSAAAYMNPMAALATQIPHGLNGTGQPPSLPSPTMPNFNMGANTPNGQPGGAAAAAAAAAAADGVFTNGIPQTAFPGHPLHLTIPPQGLPNGDAATLQHAFPGLPPFPGVAFPAVYGQFPQALPPPLAAVAPTQREDFLMFPGCSISGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRPY
Protein: Protocadherin 18 (Q8VHR0)
Organism: Mus musculus (Mouse)
Function: Potential calcium-dependent cell-adhesion protein.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MHQMNTKMHFRFALALLMAFFSHDVLAKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSAVRFRAMPRGNSPLLVVNENTGEISIGAKIDREQLCQKNLNCSIEFDVLTLPTEHLQLFHIEVDVLDINDNSPQFSRPVIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDYFNIEVRTRTDGAKYAELIVVKELDRELKASYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQPSYTIQLLENSPVGTLLLDLNATDPDEGANGRIVYSFSSHVSPKIIETFKIDSEKGHLTLFKPVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEISINLMSPGKEEVSYVFEGDPIDTFVAIVRVQDKDSGLNGEIICKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDKGTPSLSSVRHFTVQINDINDNPPRFQRSRYEFVISENNSPGAYITTVTATDPDLGENGHVTYTILESFVLGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSQKQLSSNTTVVLTIIDENDNVPVVIGPAMHNNTAEISIPKGAESGFHVTRIRVVDRDSGANAEFSCSIVSGNEENIFIMDPRSCDIHTNVSMESIPSAEWALSVIIQDKGSPPLHTKVLLRCMVFDYAESVTSTAMTSVSRASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPAQPQQQHSHQGLDDDSQPAENGEKKKSFSTFGKDSPSDEDSGDSSTSSLLSEMSSVFQRLLPASLDTFSECNEGDRSNSLERRKGPAQGKTGGYPQGVAAWAASTHFQNPTSSSGTPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLSDGKHELMDASELVAEINKLLQDVRQS
Protein: Ubiquitin homeostasis protein lub1 (O94289)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a negative regulator of vacuole-dependent ubiquitin degradation.
Subcellular location: Nucleus {ECO:0000269|PubMed:14993272}. Cytoplasm {ECO:0000269|PubMed:14993272}.
Interaction partners:
- Cell division cycle protein 48
- Ubiquitin fusion degradation protein 1
- Nuclear protein localization protein 4
- Putative ubiquitin thioesterase otu1
- UBX domain-containing protein 3
- Polyubiquitin
- UBX domain-containing protein 10
- ATPase family gene 2 protein
- Ankyrin and IPT/TIG repeat-containing protein C26H5.05
- AN1-type zinc finger protein C1271.05c
Sequence:
MTSYELSRELGGHKQDVRGVCSISNELIGSASRDGTYSVWEQINGEWTPHFYENHEGFVNCVCYVPAIDKNSRGYIFSGGQDKCGILQEVGTNSPSYYLFGHESNICSASALNSETIITGSWDSTARVWALGQCKYVLKGHQSSVWAVLALGEDIFITGSADKLIKIWNGEKLVKSILAHNDCVRSLCQIPGGFASCSNDGVIKLWTSDGEFLYELHGHTSFVYSLTYIHNQQLIASCGEDRTIRIWKGKECLQCITLPTTSVWSVSSLPNGDLVCGSSDGFVRIFTVDKVRVAPTEVLKNFEERVSQFAISSQEVGDIKKGSLPGLEILSKPGKADGDVVMVRVNNDVEAYQWSQKENEWKKIGQVVDAVGNNRKQLFEGKEYDYVFDVDVADGQAPLKLPYNATENPYQAANRFLELNQLPLSYTDEVVKFIEKNTQGHSLESKKEPNLESQSSNKIKTTIFPVSQLLFSNANVPAMCQRLRSLNNTKSNPLPAKSIDSLERALSSKKITDTEKNELLETCLSILDSWSLAERFPALDALRLLAINSSSDLAPIFLEVFSRVVKSVPSSGNFESINVMLALRGLSNVVPNITDAEGVSKLMDCLTSTVPQASSAKDFKIAFATLAMNLSILLIQLNLENTGIELLSILFSFLDDPSPDNEAFYRALMALGTLCTVPDIALAASQIYHAQSIVHGIAERFSQEMRFVDAEKQILSLF
Protein: AT3g15940/MVC8_7 (Glycosyl transferases-like protein) (Glycosyltransferase) (UDP-Glycosyltransferase superfamily protein) (Q9LSB5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEDLRLSPLKLGSFKSSLSGRSTPRGSPTLRKVHSGRTPRREGKGSGGAVQWFRSNRLLYWLLLITLWTYLGFYVQSRWAHDDDNKVEFLRFGGKLREDVLHVEQNKRRDLVADESSHAVVDHTNIVHLGVNKRMHVTLAKKEDSTSRRSVSPRRRTRKASRSSRTRIRSTQKVRKVMETKELDEQDQELPNINVTYGKLFGPFGSLEDRILEWSPQKRSGTCDRKSDFKRLVWSRRFVLLFHELSMTGAPISMMELASELLSCGATVYAVVLSRRGGLLQELTRRRIKVVEDKGELSFKTAMKADLVIAGSAVCASWIDQYMDHHPAGGSQIAWWVMENRREYFDRAKPVLDRVKLLIFLSEVQSKQWLTWCEEDHVKLRSQPVIVPLSVNDELAFVAGVSSSLNTPTLTQETMKEKRQKLRESVRTEFGLTDKDMLVMSLSSINPGKGQLLLLESVALALEREQTQEQVAKRNQSKIIKNLNGIRKEKISLSARHRLRGSSRKMKITSPAVDNHPSVLSATGRRKLLLSGNVTQKQDLKLLLGSVGSKSNKVAYVKEMLSFLSNNGNLSNSVLWTPATTRVASLYSAADVYVTNSQGVGETFGRVTIEAMAYGLPVLGTDAGGTKEIVEHNVTGLLHPVGRAGNKVLAQNLLFLLRNPSTRLQLGSQGREIVEKMYMKQHMYKRFVDVLVKCMRP
Protein: Protamine-2 (Sperm histone P2) (Sperm protamine P2) (Q1LZN1)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVRYRVRSLSERSHEVYRQQLHGQEQGHHGQEEQGLSPEHVEVYERTHGQSHYRRRHCSRRRLHRIHRRQHRSCRRRKRRSCRHRRRHRRGCRTRKRTCRRH
Protein: Clampless protein 1 (CLP1) (P0CP18)
Organism: Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Function: Required for developmental progression after cells of opposite mating types fuse with one another, essential for processes common to both dikaryotic filament formation and monokaryotic fruiting. A direct target for transcription factors Sxi1-alpha and Sxi2-a.
Interaction partners:
Sequence:
MATYLAPPVSSNKENSPAPNIALSDIDAISLSLRTSLSGVTLPAKKKVAALGLGRAPKFTYRRHSNKPYNRSTSITRAKKAAVQTKSVRSKAAVKKSNTRPLPLKLVQRLDVESARLERLRKAVWNPPAPVPGQVRVPLKLPYPRFPSIEYIDNEYLKEIPVQYIFDRMVPLLPSIATITLAYQPYASIPHPDSKILRDTTLAFAIPEVIDGRKPHWAAKARGREPDLALAVAYKSGEGSNGNTVVAVNSLAFATQCAYWPRLLTTSIPIPTPKRPTPSASAVSTSLPAIVETEENVSDASFSSSSSWSDSDSEVEFIDLPRLPRPVKDDKGFLHLPLVELPIPSPSTFPIIHRHLHHPSRALLPDLLGLPEHYTTRSQVLDAISGLSVQQLMDKLTTLQGVWQNLCSLGIGRLGTWRQLGEAWACVVGVIAGQGLLIAGQEEAEVQRTGRKTAAEDVAWEWVRREKAKEQQ
Protein: Arginine repressor (Q9Z8Z1)
Organism: Chlamydia pneumoniae (Chlamydophila pneumoniae)
Function: Regulates arginine biosynthesis genes.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- ABC Amino Acid Transporter ATPase
- ABC Amino Acid Transporter Permease
- Conserved outer membrane lipoprotein protein
Sequence:
MKKKVTIDEALKEILRLEGAATQEELCAKLLAQGFATTQSSVSRWLRKIQAVKVAGERGARYSLPSSTEKTTTRHLVLSIRHNASLIVIRTVPGSASWIAALLDQGLKDEILGTLAGDDTIFVTPIDEGRLPLLMVSIANLLQVFLD
Protein: DNA endonuclease I-CreI (EC 3.1.-.-) (23S rRNA intron protein) (P05725)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Endonuclease involved in group I intron homing. Recognizes and cleaves a 19-24 bp palindromic DNA site.
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MNTKYNKEFLLYLAGFVDGDGSIIAQIKPNQSYKFKHQLSLTFQVTQKTQRRWFLDKLVDEIGVGYVRDRGSVSDYILSEIKPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDKFLEVCTWVDQIAALNDSKTRKTTSETVRAVLDSLSEKKKSSP
Protein: HTH-type transcriptional regulator LysG (P9WMF5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Positively regulates the expression of the exporter LysE and represses its own expression. Activity requires the presence of a coinducer, lysine or histidine. Acts by binding to lysG-lysE promoter region. Also up-regulates the expression of ppsB, ppsC and ppsD, by binding to the upstream region of ppsB.
Interaction partners:
- Lysine exporter LysE
- Transcriptional regulatory protein
- Possible transcriptional regulatory protein
- Uncharacterized HTH-type transcriptional regulator Rv0494
- Putative amino-acid transporter Rv0488
- Probable transcriptional regulatory protein
- HTH-type transcriptional regulator LrpA
- Putative antitoxin HigA3
- Putative mycofactocin biosynthesis transcriptional regulator MftR
- Probable transcriptional regulatory protein
Sequence:
MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLEQQVGQVLVVREKPCRATTAGIPLLRLAAQTALLESEALAEMGGNASLKRTRITIAVNADSMATWFSAVFDGLGDVLLDVRIEDQDHSARLLREGVAMGAVTTERNPVPGCRVHPLGEMRYLPVASRPFVQRHLSDGFTAAAAAKAPSLAWNRDDGLQDMLVRKAFRRAITRPTHFVPTTEGFTAAARAGLGWGMFPEKLAASPLADGSFVRVCDIHLDVPLYWQCWKLDSPIIARITDTVRAAASGLYRGQQRRRRPG
Protein: Mitochondrial import inner membrane translocase subunit TIM50 (Q6NWD4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q3ZCQ8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q3ZCQ8}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim21
- Mitochondrial import inner membrane translocase subunit Tim23
- Mitochondrial import inner membrane translocase subunit tim16
- Mitochondrial import inner membrane translocase subunit Tim17-B)
- Translocase of inner mitochondrial membrane 23 homolog b
- Mitochondrial import inner membrane translocase subunit TIM17
- Mitochondrial import inner membrane translocase subunit Tim10
- Translocase of outer mitochondrial membrane 70 homolog A
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import receptor subunit TOM40 homolog)
Sequence:
MSAVSVYPMCVRASRGLLRLRQGARCSTAPPLLDVVRPLSADTSSSSATGGLAQAILQERLQQQQKSQEQPPPEGEDSGHKQDEQGEDKKQKENTAYAKKMVLRLAGIMGLGGTVGIVYIFGSNSVDEQGNKIPDEFDNDVPVIQQLRRTFKYFKDYRQMIIEPTSPKLLPDPLREPYYQPPYTLVLELTDVLLHPEWSLATGWRFKKRPGIDYLFQQLAPLYEIVIFTSETGMTAYPLIDSIDPQGFVMYRLFRDATRYMEGHHVKDVSCLNRDTSKVIVVDCKREAFGLQPFNGLALCKWDGNSEDRTLYDLAAFLKTIATSGVEDVRSVLENYAHEEDPIEAFKRRQAQLAREEEQRISEMAQQKKQGFSLGTIAGRFWSRKQQ
Protein: Mitochondrial dicarboxylate carrier (DIC) (Solute carrier family 25 member 10) (Q9QZD8)
Organism: Mus musculus (Mouse)
Function: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane. Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:10567211}; Multi-pass membrane protein.
Interaction partners:
- Large ribosomal subunit protein bL12m
Sequence:
MAEARASRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALQVVRTDGFLALYNGLSASLCRQMTYSLTRFAIYETMRDYMTKDSQGPLPFYNKVLLGGISGLTGGFVGTPADLVNVRMQNDMKLPPSQRRNYSHALDGLYRVAREESLRKLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVSSFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAMETAKLGPQAFFKGLFPAGIRLIPHTVLTFMFLEQLRKHFGIKVPTT
Protein: Proline-rich protein LAS17 (Q12446)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Actin-related protein 2
- Protein BZZ1
- Reduced viability upon starvation protein 167
- Actin-related protein 3
- Verprolin
- Actin cytoskeleton-regulatory complex protein SLA1
- Myosin-3
- LAS seventeen-binding protein 3
- Actin
- Actin cytoskeleton-regulatory complex protein PAN1
Sequence:
MGLLNSSDKEIIKRALPKASNKIIDVTVARLYIAYPDKNEWQYTGLSGALALVDDLVGNTFFLKLVDINGHRGVIWDQELYVNFEYYQDRTFFHTFEMEECFAGLLFVDINEASHFLKRVQKRERYANRKTLLNKNAVALTKKVREEQKSQVVHGPRGESLIDNQRKRYNYEDVDTIPTTKHKAPPPPPPTAETFDSDQTSSFSDINSTTASAPTTPAPALPPASPEVRKEETHPKHSLPPLPNQFAPLPDPPQHNSPPQNNAPSQPQSNPFPFPIPEIPSTQSATNPFPFPVPQQQFNQAPSMGIPQQNRPLPQLPNRNNRPVPPPPPMRTTTEGSGVRLPAPPPPPRRGPAPPPPPHRHVTSNTLNSAGGNSLLPQATGRRGPAPPPPPRASRPTPNVTMQQNPQQYNNSNRPFGYQTNSNMSSPPPPPVTTFNTLTPQMTAATGQPAVPLPQNTQAPSQATNVPVAPPPPPASLGQSQIPQSAPSAPIPPTLPSTTSAAPPPPPAFLTQQPQSGGAPAPPPPPQMPATSTSGGGSFAETTGDAGRDALLASIRGAGGIGALRKVDKSQLDKPSVLLQEARGESASPPAAAGNGGTPGGPPASLADALAAALNKRKTKVGAHDDMDNGDDW
Protein: Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) (Q9H1R3)
Organism: Homo sapiens (Human)
Function: Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
Subcellular location: Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
Interaction partners:
- Calmodulin-like protein 6
- Calmodulin-like protein 4
- Calmodulin-like protein 5
- Calmodulin-like protein 3
- Calmodulin-1
- Myosin regulatory light chain 12A
- Myosin regulatory light polypeptide 9
- Myosin light chain 3
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin regulatory light chain 12B
Sequence:
MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVPMTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
Protein: ToMV resistance protein Tm-2(GCR236) (Disease resistance protein Tm-2) (Q71BH0)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Inhibitor of viral mouvements which confers resistance to some tobamoviruses including tomato mosaic virus (ToMV) (e.g. isolates L, W3 and SL-1) and tobacco mosaic virus (TMV), but not to resistance-breaking isolates (e.g. B7, LT1, LII, Ltbl, ToMV2, and ToMV1-2) ToMV and tomato brown rugose fruit virus (ToBRFV). Elicits a hypersensitive reaction in response to avirulent (Avr) movement proteins from resistance inducing tobamoviruses (e.g. ToMV and TMV) strains, thus leading to programmed cell death.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q71BG9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q71BG9}; Cytoplasmic side {ECO:0000250|UniProtKB:Q71BG9}.
Interaction partners:
- ToMV susceptible protein tm-1
- ToMV resistance protein Tm-1
- Agamous-like MADS-box protein AGL9 homolog
Sequence:
MAEILLTSVINKSVEIAGNLLIQEGKRLYWLKEDIDWLQREMRHIRSYVDNAKAKEAGGDSRVKNLLKDIQELAGDVEDLLDDFLPKIQQSNKFNYCLKRSSFADEFAMEIEKIKRRVVDIDRIRKTYNIIDTDNNNDDCVLLDRRRLFLHADETEIIGLDDDFNMLQAKLLNQDLHYGVVSIVGMPGLGKTTLAKKLYRLIRDQFECSGLVYVSQQPRASEILLDIAKQIGLTEQKMKENLEDNLRSLLKIKRYVFLLDDIWDVEIWDDLKLVLPECDSKVGSRIIITSRNSNVGRYIGGESSLHALQPLESEKSFELFTKKIFNFDDNNSWANASPDLVNIGRNIVGRCGGIPLAIVVTAGMLRARERTEHAWNRVLESMGHKVQDGCAKVLALSYNDLPIASRPCFLYFGLYPEDHEIRAFDLINMWIAEKFIVVNSGNRREAEDLAEDVLNDLVSRNLIQLAKRTYNGRISSCRIHDLLHSLCVDLAKESNFFHTAHDAFGDPGNVARLRRITFYSDNVMIEFFRSNPKLEKLRVLFCFAKDPSIFSHMAYFDFKLLHTLVVVMSQSFQAYVTIPSKFGNMTCLRYLRLEGNICGKLPNSIVKLTRLETIDIDRRSLIQPPSGVWESKHLRHLCYRDYGQACNSCFSISSFYPNIYSLHPNNLQTLMWIPDKFFEPRLLHRLINLRKLGILGVSNSTVKMLSIFSPVLKALEVLKLSFSSDPSEQIKLSSYPHIAKLHLNVNRTMALNSQSFPPNLIKLTLANFTVDRYILAVLKTFPKLRKLKMFICKYNEEKMDLSGEANGYSFPQLEVLHIHSPNGLSEVTCTDDVSMPKLKKLLLTGFHCRISLSERLKKLSK
Protein: Protein MAK16 (Maintenance of killer protein 16) (P10962)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Its role might be as part of the apparatus concerned with the nuclear events of the cell cycle.
Subcellular location: Nucleus.
Interaction partners:
- Ribosome biogenesis protein NSA1
- Nucleolar complex-associated protein 3
- Ribosome biogenesis protein NSA2
- Ribosome biogenesis protein ERB1
- Ribosomal RNA-processing protein 1
- 27S pre-rRNA
- Ribosome production factor 1
- Ribosome biogenesis protein YTM1
- Ribosome biogenesis protein RLP24
- Nucleolar GTP-binding protein 1
Sequence:
MSDEIVWQVINQSFCSHRIKAPNGQNFCRNEYNVTGLCTRQSCPLANSKYATVKCDNGKLYLYMKTPERAHTPAKLWERIKLSKNYTKALQQIDEHLLHWSKFFRHKCKQRFTKLTQVMITERRLALREEERHYVGVAPKVKRREQNRERKALVAAKIEKAIEKELMDRLKSGAYGDKPLNVDEKVWKKIMGQMEEENSQDEEEDWDEEEESDDGEVEYVADDGEGEYVDVDDLEKWLADSDREASSASESESDSESESDSDSDEENKNSAKRRKKGTSAKTKRPKVEIEYEEEHEVQNAEQEVAQ
Protein: IP12392p (Q8IMT3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RE37682p
- Uncharacterized protein, isoform A
Sequence:
MSGNPQNNQFNDDELVPPEWLNSEFMARVLEGNELEAAVKVIDLTFSPASAKGDHYASIMFRARVKYTNRKGEFQKSLIIKTMPEAEGHKKDMLGGSPIFETEMGLYTKVLPEFERILRQVGDDTQLYVNCIYHSLEPHQVLIFEDLAEMGYIVLRDRDATLDEIRRIYFKLAKWHAVSLKVQNEQPEFLESYTHGLFEMPHVLNDPFMRTGMEFFVELLGKEPELNKYKPYFESIKDDFLERLVEEWKDIRKSQKKDEYWVLCHGDLHLRNIMFKHKDTVSLEDCMLLDFQISNLFPLTFDLLYSIYMLLEPEHRWNNWDDLINYYISVLQDVLKKIGYKGVMPSQSGLWKRLHQHKYYEFFLISTFLPLMWALRDKSVDFGDLLQNEEKRRKCSFSKGYIKEVTILLARLDQLGLLHA
Protein: Ion transport domain-containing protein (Q3UQG9)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMIVGVVVENFHKCRQHQEEEEARRREEKRLKRLEKKRRSKEKQMADLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGVNSPDSPKPGAPHTTAHIGAASSGFSLEHPTMVPHTEEGPVPLGPDLLTVRKSGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGLPKAQSGSILSVHSQPADTSCILQLPKDAHYLLQPHGAPTWGAIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSSFWGGSSIQVQQRSGSQSKVSKHIRLPAPCPGLEPSWAKDPQETRSSLELDTELSWISGDLLPSSQEEPLSPRDLKKCYSVEAQSCRRRPGSWLDEQRRHSIAVSCLDSGSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGPRPPCSPGVCLRRRAPASDSKDPSASSPLDSTAASPSPKKDALSLSGLSSDPTDLDP
Protein: Mast cell protease-11 (Protease serine 34) (Serine protease 34) (Q80UR4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MCLGMLWLLFLSLPCLGNTMPLTLDLGSGQGLVGIVGGCPVSASRFPWQVSLRLYDMEHSRWEHECGGSLIHPQWVLTAAHCVRPKEVEAYGVRVQVGQLRLYENDQLMKVVKIIRHPKFSEKLSARGGADIALLKLDTRVVLSEHVYPVSLPAASLRISSKKTCWVAGWGVIENYMPLPPPYHLREVAVPIVENNDCEQKYQTNSSSDSTTRIIKDDMLCAGKEGRDSCKADSGGPLVCRWNCSWVQVGVVSWGIGCGLPDFPGVYTRVMSYVSWIKCYVPTFLEPLKGPDGIHTTEETPATHIDPFTPPSGPASLS
Protein: H(+)-transporting two-sector ATPase (EC 7.1.2.2) (Q7SY46)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDFSKLPKIRDEERESQFGYVHGVSGPVVTASSMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVCVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDINDLTQSIYIPRGVNIGALNRDLKWDFTPINNLRVGSHVTGGDIYGLVNENSLIKHKLMLPPRSRGTVTYVAPPGNYDVSDVVLELEFEGVKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVGGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYTRALDEYYDKHFQEFVPLRTKAKEILQGEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGILSNMIAFYDLARHAVETTAQSDNKITWAQIREHMGEILYRISSMKFKDPVKEGEAKIKADYAQLLEDMQNSFRTLED
Protein: Cruzioseptin-6 (CZS-6) (A0A193H396)
Organism: Cruziohyla calcarifer (Splendid leaf frog) (Agalychnis calcarifer)
Function: Has antimicrobial activity.
Subcellular location: Secreted {ECO:0000269|PubMed:27321580}.
Interaction partners:
Sequence:
MAYLKKSLFLVLFLGLVSLSICEEEKREEENEEEQEDDDQSEEKRGFLDVITHVGKAVGKAALNAVTEMVNQAEQ
Protein: 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 (EC 1.1.1.395) (3alpha-hydroxysteroid dehydrogenase 2) (3alpha-HSDH 2) (Bile acid-inducible protein BaiA2) (P19337)
Organism: Clostridium scindens (strain JCM 10418 / VPI 12708)
Function: Involved in the multi-step bile acid 7alpha-dehydroxylation pathway that transforms primary bile acids to secondary bile acids in the human gut. Catalyzes the oxidation of C3-hydroxyl group of CoA conjugated bile acids generating a C3-oxo bile acid intermediate. Can use choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA as substrates with similar efficiency. Highly prefers NAD over NADP as cosubstrate. Also catalyzes the reverse reactions; in vitro, the preferred direction of reaction depends on the pH. Has very little activity with unconjugated (non-CoA) bile acid substrates.
Interaction partners:
Sequence:
MNLVQDKVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSRDAVMAAVGQVAQKYGRLDVMINNAGITSNNVFSRVSEEEFKHIMDINVTGVFNGAWCAYQCMKDAKKGVIINTASVTGIFGSLSGVGYPASKASVIGLTHGLGREIIRKNIRVVGVAPGVVNTDMTNGNPPEIMEGYLKALPMKRMLEPEEIANVYLFLASDLASGITATTVSVDGAYRP