Protein: Atypical protein kinase C (EC 2.7.11.13) (A1Z9X0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Serine/threonine protein kinase which is required for apico-basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishment of correct oocyte polarity. Essential for apical localization of l(2)gl and par-6 in neuroblasts and for exclusion of mira from the apical cortex. Phosphorylates baz which is required for targeting of baz to the postsynaptic region where it is involved in actin organization, and for apical exclusion of baz which is necessary for establishment of the apical/lateral border in epithelial cells. Phosphorylates yrt which prevents its premature apical localization and is necessary for correct epithelial cell polarization. Required for the establishment of mitotic spindle orientation during symmetric division of epithelial cells and for apical exclusion of raps/Pins. Involved in symmetric adherens junction positioning during embryogenesis. Required for polarization of the spermatid cyst which is necessary for sperm differentiation. Required for stimulation of the Toll signaling pathway which activates Dif and dl and plays a role in innate immunity. Plays a role in memory enhancement.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:10995441, ECO:0000269|PubMed:11734648, ECO:0000269|PubMed:15302858, ECO:0000269|PubMed:18614576, ECO:0000269|PubMed:20434988, ECO:0000269|PubMed:24830287}. Apicolateral cell membrane {ECO:0000269|PubMed:10995441, ECO:0000269|PubMed:11734648, ECO:0000269|PubMed:15302858, ECO:0000269|PubMed:18614576, ECO:0000269|PubMed:20434988, ECO:0000269|PubMed:24830287}; Peripheral membrane protein {ECO:0000269|PubMed:10995441, ECO:0000269|PubMed:11734648, ECO:0000269|PubMed:15302858, ECO:0000269|PubMed:18614576, ECO:0000269|PubMed:20434988, ECO:0000269|PubMed:24830287}. Note=Cytoplasmic at interphase but localizes to the apical cell cortex during mitosis. {ECO:0000269|PubMed:10995441, ECO:0000269|PubMed:11734648, ECO:0000269|PubMed:15302858, ECO:0000269|PubMed:18614576, ECO:0000269|PubMed:20434988, ECO:0000269|PubMed:24830287}.
Interaction partners:
- Lethal
- Bazooka, isoform B
- LD29223p
- Cdc42 homolog
- Patj homolog
- Protein crumbs
- Protein PALS1
- Protein numb
- Inscuteable
- Moesin/ezrin/radixin homolog 1
Sequence:
MQKMPSQILNDGSSVSLNSASMNMANTPNSITVKTAYNGQIIITTINKNISYEELCYEIRNICRFPLDQPFTIKWVDEENDPCTISTKMELDEAIRLYEMNFDSQLVIHVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV