wanglab/gogpt-training-data huggingface dataset:
Protein: Glycine N-methyltransferase (EC 2.1.1.20) (Folate-binding protein) (P13255)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:6587377}.
Interaction partners:
- Dimethylglycine dehydrogenase, mitochondrial
- Sarcosine dehydrogenase, mitochondrial
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase
- Pipecolic acid and sarcosine oxidase
- 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
- Alanine--glyoxylate aminotransferase
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- D-amino-acid oxidase
- Glycine amidinotransferase, mitochondrial
Sequence:
MVDSVYRTRSLGVAAEGIPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRKEPAFDKWVIEEANWLTLDKDVPAGDGFDAVICLGNSFAHLPDSKGDQSEHRLALKNIASMVRPGGLLVIDHRNYDYILSTGCAPPGKNIYYKSDLTKDITTSVLTVNNKAHMVTLDYTVQVPGAGRDGAPGFSKFRLSYYPHCLASFTELVQEAFGGRCQHSVLGDFKPYRPGQAYVPCYFIHVLKKTG
Protein: Galactinol synthase 1 (AtGolS1) (GolS-1) (EC 2.4.1.123) (O22893)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Galactinol synthase involved in the biosynthesis of raffinose family oligosaccharides (RFOs) that function as osmoprotectants. Promotes plant stress tolerance such as heat, chilling, salinity and methylviologen (MV), a superoxide radical generating drug, by mediating raffinose accumulation, an osmoprotective substance.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Probable galactinol--sucrose galactosyltransferase 5
- Probable galactinol--sucrose galactosyltransferase 1
- Probable galactinol--sucrose galactosyltransferase 2
- Probable galactinol--sucrose galactosyltransferase 6
- UDP-sugar pyrophosphorylase
- ADP-glucose phosphorylase
- L-ascorbate peroxidase 2, cytosolic
- Heat stress transcription factor A-2
- Probable galactinol--sucrose galactosyltransferase 4
- UDP-glucose 4-epimerase 5
Sequence:
MAPGLTQTADAMSTVTITKPSLPSVQDSDRAYVTFLAGNGDYVKGVVGLAKGLRKVKSAYPLVVAMLPDVPEEHRRILVDQGCIVREIEPVYPPENQTQFAMAYYVINYSKLRIWKFVEYSKMIYLDGDIQVYENIDHLFDLPDGYLYAVMDCFCEKTWSHTPQYKIRYCQQCPDKVQWPKAELGEPPALYFNAGMFLYEPNLETYEDLLRTLKITPPTPFAEQDFLNMYFKKIYKPIPLVYNLVLAMLWRHPENVELGKVKVVHYCAAGSKPWRYTGKEANMEREDIKMLVKKWWDIYDDESLDYKKPVTVVDTEVDLVNLKPFITALTEAGRLNYVTAPSAA
Protein: Salt tolerance receptor-like cytoplasmic kinase 1 (EC 2.7.12.1) (Receptor-like cytoplasmic kinase 154) (OsRLCK154) (A2XW02)
Organism: Oryza sativa subsp. indica (Rice)
Function: Acts probably as a dual specificity protein kinase (Probable). Regulates hydrogen peroxide (H(2)O(2)) homeostasis and improves salt tolerance by phosphorylating tyrosine residues of CATC thus activating its catalase activity. Promotes growth at the seedling stage and prevents grain yield loss under salt stress conditions (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q7XR88}; Lipid-anchor {ECO:0000250|UniProtKB:Q7XR88}.
Interaction partners:
Sequence:
MFTGCGLFACVRRCDGGDVRKRGEAGAMSSRVAADPAGVEEEGSCKNVAAASARQLAWADVESVTGGFSSRVIGHGGFSTVYLASLSSSRLGAVKVHCSSERLHRAFRQELEVLLSLRHPHIVRLLGYCDERDEGVLVFEYAPNGDLHERLHCSEVAGGVASVLPWARRVAIAFQVAMALEYLHESRHPAVIHGDIKASNVLLDANMNAKLCDFGFAHVGFSATVGCRPSARAVMGSPGYVDPHLIRSGVATKKSDVYSFGVLLLELVTGKEAVCRDTGRRLTAAVGPMLSEGKVADVVDRRLGGEHDGAEAAVMAELAMQCIGDSPGLRPSMADVVRALQEKTSALASAVGSRLDRKMMF
Protein: PAPS synthetase, isoform E (EC 2.7.1.25, EC 2.7.7.4) (PAPS synthetase, isoform F) (PAPS synthetase, isoform H) (RE03925p) (Q7KUT8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPNPPIGFYPHIKRRCLQVATNVTEQKHHVTRETRGKNLGLCRGFRGCTVWLTGLSGAGKTSIAFELEAYLVSRGIPAYGLDGDNIRTGLNKNLGFTPADREENIRRVGEVAKLFADSGVVAICSFVSPFADDREMARKIHKDAGLKFYEIFVDTPLDVCETRDVKGLYKKAREGVIKGFTGITQEYERPQMPELVVNTHGYTVRESTQKLVTLLEQEGIIPRSLRDVDLLPELYPSESIATEALRHEAESLQAIEISTVELQWVQVLAEGWAYPLRGFMREDEYLQTLHFNTLQSGMDGSYRENHSVPIVLSATQADKDRLDGCSSLTLKYQGKAVAILRRPEFYFQRKEERLARQFGTSNPNHPYSKQVYESGDYLVGGDLAVIERIRWEDGLDQYRLTPNELRRRFKELNADAIFAFQLRNPIHNGHALLMQDTRRQLLERGFKQPVLLLHPLGGWTKDDDVPLDVRMKQHQAVLDAGVLRREDTVLAIFPSPMMYAGPTEVQWHAKARMNAGANFYIVGRDPAGMPHPAKETYPDGNLYDATHGARVLKMAQGLDSMEILPFRVAAYDKSASRMAFFEPKRKDEFEFISGTKMRTLAKTGASPPDGFMEPEAWRILATYYQNLPQS
Protein: Small ribosomal subunit protein uS7B (40S ribosomal protein S5-B) (Q9P3T6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS15
- Elongation factor 3
- mRNA export factor elf1
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS27
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein eS21
Sequence:
MAASIIPKEVSLDETGHIKLFNKFPFEGVEVKDISLVDYITIGNGQPLPHTAGRFQTKRFRKARCFIVERLTNSLMMNGRNNGKKLLATRIVKHAFEIIALLTDQNPLQVLVDAVAACGPREDSTRIGSAGTVRRQAVDVSPLRRVNQALALITIGAREAAFRNVKSISECLAEEIINAAKGSSNSYAIKKKDELERVAKSNR
Protein: Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) (Q06418)
Organism: Homo sapiens (Human)
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Growth arrest-specific protein 6
- Vitamin K-dependent protein S
- Suppressor of cytokine signaling 1
- Tubby-related protein 1
- Interferon alpha/beta receptor 1
- T-cell immunoglobulin and mucin domain-containing protein 4
- Suppressor of cytokine signaling 3
- CD209 antigen
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
Protein: Lysine-specific histone demethylase (EC 1.14.99.66) (B3STT9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR038051}.
Interaction partners:
Sequence:
MLSGKKAAAAAAAAAAAAAGTEAGPGAAGGAENGSEVAAPPAGLAGPADIATGAAGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTAGPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGQAGGLQDDSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPIKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
Protein: Death effector domain-containing protein (Death effector domain-containing testicular molecule) (Q9Z2K0)
Organism: Rattus norvegicus (Rat)
Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli. Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MAGLKRRASQVWPEERVEQEHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVTLKKRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGSQMCSKRPARGRTTLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP
Protein: Uncharacterized heme-binding protein C330.03c (O74875)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- NADH-cytochrome b5 reductase 1
Sequence:
MLSIFKNLLGTSEEDGTTQEANSKDTKGLKEERKRKKRKNKYKIPPGHTQQDWDALVASGKNLSGVESPISVTAEELAKHCSPDDCWMAIRGKVYNVTAYLPYHPVGPKKILKHSGVDATKPYLKHHDWVNEEELLKTSFVGYLV
Protein: Ppr1p (A0A1D8PP34)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Dilute domain-containing protein
- Major facilitator superfamily
- C2H2-type domain-containing protein
- Tos4p
- C2H2-type domain-containing protein
Sequence:
MSESPSQPPQKKHKPTTTGPSSSSSSKLTRAISACKRCRTKKIKCDQKFPQCGKCEVNGVECIGVDSVTGREIPRSYIVHLEERVKFLEEKLRLQDRSGFVDEGVSSTPPGSSTIKKKSNEISINEPLIKNESPLINTKLDSIAFSKIMSTAVRVQNRLSDPNIKPGNGNVNLGHNSTTTNENGIDINNDISRAVLPPKSTAMQFLRVFFHQCNSQLPLFHREEFLRDYFIPIYGEFDESISLASNNTKINKSFFNSSSSDGDKTPCWFDVYKSKIQQLLTENTQNDIQTIANNIIPPLKYRKPLYFLNLVFAVATSANHLRYPIHISESFRLAAMRFSQDVDNSIDPLEHLQGILLYAGYSIMRPTNPGVWYIMGEALRICVDLDLQNELKTKSKQNFNIDNFTRDKRRRIFWCCYSIDRQICFYLDRPFGIPDESINTPYPSSLDDSKIIPNDNSTDYYYYKNHHHHHHHDDDDDDNEDDINFSYKNVSLLFFKIRKIQSQVTKILYTNAEIPREYKDLNHWKQSILIQLTQWKQELQSKLISKQLNCDFNEIFFQLNYHHTLLYIHGLSPKNYKLSLIDYENLTNSSIQVINCYTELLKTKSINYTWAGVHNLFMAGTSYLYALYNSKEIRLINSIDQVQKITNDCLLVLQSLIGRCDAANYCCEIFHNLTMIIINLKYAPKDKKHLTELKPANSIPSSSFSSSSSFSSSSSTSSSKISRESLYRINNGNVHSNLFHLVTELDHLNPLTKTKTINNNNSDHFDITNDEKQDHDSTIITDDLSSPPIDSSLLPLNQQTILQWNDEELQNFLNELNQSNQSNQSSPNNNSSIRDEKKTFELIHDMPNEIIWDEFFANKQ
Protein: Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL) (P22894)
Organism: Homo sapiens (Human)
Function: Can degrade fibrillar type I, II, and III collagens.
Subcellular location: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Note=Stored in intracellular granules.
Interaction partners:
- Cell adhesion molecule CEACAM8
- Defensin alpha 4
- Neutrophil elastase
- Serpin H1
- Metalloproteinase inhibitor 2
- Olfactomedin-4
- Alpha-2-macroglobulin
- Myeloperoxidase
- Metalloproteinase inhibitor 4
- Metalloproteinase inhibitor 1
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Protein: Homocitrate synthase, cytosolic isozyme (HCS) (EC 2.3.3.14) (P48570)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.
Subcellular location: Cytoplasm.
Interaction partners:
- Homocitrate synthase, mitochondrial
- Homocitrate dehydratase, mitochondrial
- 2-isopropylmalate synthase
- Acetyl-coenzyme A synthetase 2
- Acetyl-coenzyme A synthetase 1
- 3-isopropylmalate dehydratase
- Lysine biosynthesis regulatory protein LYS14
- Homoisocitrate dehydrogenase, mitochondrial
- Acetyl-CoA acetyltransferase
- Acetyl-CoA hydrolase
Sequence:
MTAAKPNPYAAKPGDYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDAKVAVETGVDGVDVVIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPELATIPAAKRTKPSA
Protein: Vigilin (Q7ZU44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSSVAVLTQESFNEHRSGLLPEQVKAAAGGDPSSVEDDDSLPTYKDAFPPLPEKPLPEGVQETENAWTTKTKPLKSSIITQVFHVPLEERKYKDMNQFGEGDQAKVCLDIMHKTGAHLELSMAKDQGLSIMVSGKYDAVMKARKEIVSRLQTQASATVAIPKEHHRFVIGKSGEKLQELELKTATKIQIPRPDDPSNQIKISGTKEGLEKAKHEILLISAEQDKRAVERMNIDKVFHPFITGAHGKLVGDLMQETGARINVPPPSVNKTEIVITGEKEQVALAMVKIKKLYEEKKKNATTIAVEVKKSQHKYVIGPKGNTLQEILERTGVSVEIPPLDSSSETVILRGEPARLGQALTEVYAKANSYTVSSVSAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTKDVQIVQGQIEVIVTDLVSRMDYTEISVDPKFHRHLIGKGGANINRIKELHKVSVRIPPDNEKSNLIRIEGDPQGVQEAKKELLELASRMENERTKDMIIEQRFHRAIIGQKGEKIKEIRDKFPEVIINFPDPAQKSDIVQLRGPRTEVEKCSKFMQKMVAEMVENSFSVSVPIFKQFHKNIIGKGGANIKKIREETNTKIDLPAENSNSEMVVITGKKANCEAAKNRILAIQKELANITEVEVSIPSKLHNSLIGSKGRFVRSIMEECGGVHIHFPTEGSGIDAVTIRGPAEEVEKAKKQLLSLAEEKQTKSHTVELRAKPEYHKFLIGKGGGNVRKVRDSTGARIIFPTAEDKDHELITVIGTEEAVAEAQKELEALIKSLDNIVEDFMIVDPKHHRFFVARRGQVLRDIADEYGGVIVSFPRTAAQSDKVTLKGAKDCVEAAKKRMLEMIEDLDAQVTMECVIPQKFHRSIMGPKGSRIQQITKDHNVQIKFPDREEQQQADASVQENGEANGEVKEPVDPTAPKKCDVIVLSGRKERCEAAVEALKALVPVTIAVEVPFELHRYIIGQKGSGIRKMMDEFEVNIQVPAHELQSDIISITGLASHLDRAKEGLLERVKELQAEQEDRALRSFKLTITVEPKYHPKIIGRKGAIISHIRHDHEVNIQFPEKNDENQDQITITGYEQNAIAARDAIQAIVDELEEMISEDITLDSRVHARIIGARGKGIRKIMDEFKVDVRFPQSGAADPNLVTVTGRPEHVDEAIDHLLNLEEEYMADVVENEAKMAYM
Protein: Chemotaxis protein CheA (EC 2.7.13.3) (P29072)
Organism: Bacillus subtilis (strain 168)
Function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to CheB, CheY or CheV.
Subcellular location: Membrane {ECO:0000305}. Note=It is not known whether CheA is actually membrane bound although CheA has two regions at the C-terminal end with the potential to be transmembrane regions.
Interaction partners:
- Chemotaxis protein CheY
- Chemoreceptor glutamine deamidase CheD
- CheY-P phosphatase CheC
- Chemotaxis protein CheV
- Flagellar motor switch phosphatase FliY
- Chemotaxis protein CheW
- Protein-glutamate methylesterase/protein-glutamine glutaminase
- Flagellar motor switch protein FliM
- Methyl-accepting chemotaxis protein McpB
- Methyl-accepting chemotaxis protein McpC
Sequence:
MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRAAHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQSIIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEEQGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVCFLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQKQPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTETVERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDRTVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDGAGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDVVKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETAVIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAFVVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII
Protein: NADPH oxidase 2 (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b-245 heavy chain) (Heme-binding membrane glycoprotein gp91phox) (Neutrophil cytochrome b 91 kDa polypeptide) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome) (B8YQA0)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MGNFAANEGLSVFVILVWLGINAYLFVQFYMNFLTERWFYTRVLIGDALSWARAPAACLNFNCMLILLPVCRNLLSFLRGSIQCCSRTAARQLDRNITFHKLVAYMIAFHTAVHIIAHLFNFEWFMGAQLYRNSSSLPFVLSQIGTGDNASYLNPIRTDQTNPTIVMFTTIAGLTGVVITLALILIITSSMEVIRRSYFEVFWYTHHLFIIFFIGLVFHGFGRIVRGQTATSLLENKPSQCADQFESWGKNGTFCPKPEFAGNPPMTWKWVVGPMILYVCERLVRFYRSQQKVVITKVVMHPSKTLELQMKRKGFRMEVGQYVFMQCPCVSQLEWHPFTLTSAPEEDHFSVHIRIVGDWTQGLYEACGGDKNETQEAWKLPKMAIDGPFGTASEDVFGYEVVMLVGAGIGVTPFASVLKSVWYKHIQENQNVFTKKIYFYWLCPETQAFEWFADLLQSLEGQMTEKGMVDFLSYNIYLTRWKETEAAHFRVHHEAENDPITGLKQKTLYGKPNWDNEFTTIGTKHPEKKVGVFLCGPTQLADVLEKQCLSHSEAGVKFIFNKENF
Protein: Uncharacterized protein PB24D3.07c (Q9C0Y7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta
- Zinc-type alcohol dehydrogenase-like protein PB24D3.08c
Sequence:
MKSFVWTLLGALSLGSLTTAYGANASNSSVPTPDNTLVVSYTNTSCYTSGPLSPDTRFNRTTRGTFSKVRDALKFRLNGPIHHWDIANELFDTALGVEIIDTQYGINNRTSRDWCTAVSALEKGDLIEFAAAFTAFDDVNPTKEVVPDALVGTLALWAKYSYEYDLTSIVSLFGKNWTVDELGWGTYIAHSLNEISSNTTGAANATLFIDTQTKSDCYKLASTIESWKYAPLSAFPNYGPFYIYGQCVATFTSGYSPLVEPAFTFASALNTTLNSFPNGTLPTQTQVVGDIGVKFLQYFA
Protein: ATP-dependent RNA helicase DDX60 (A0A3G9HN97)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MERNVLTTFSQEMSQLILNEMPKAEYSSLFNDFVESEFFLIDGDSLLITCICEISFKPGQNLHFFYLVERYLVDLISKGGQFTIVFFKDAEYAYFNFPELLSLRTALILHLQKNTTIDVRTTFSRCLSKEWGSFLEESYPYFLIVADEGLNDLQTQLFNFLIIHSWARKVNVVLSSGQESDVLCLYAYLLPSMYRHQIFSWKNKQNIKDAYTTLLNQLERFKLSALAPLFGSLKWNNITEEAHKTVSLLTQVWPEGSDIRRVFCVTSCSLSLRMYHRFLGNREPSSGQETEIQQVNSNCLTLQEMEDLCKLHCLTVVFLLHLPLSQRACARVITSHWAEDMKPLLQMKKWCEYFILRNIHTFEFWNLNLIHLSDLNDELLLKNIAFYYENENVKGLHLNLGDTIMKDYEYLWNTVSKLVRDFEVGQPFPLRTTKVCFLEKKPSPIKDSSNEMVPNLGFIPTSSFVVDKFAGDILKDLPFLKSDDPIVTSLVKQKEFDELVHWHSHKPLSDDYDRSRCQFDEKSRDPRVLRSVQKYHVFQRFYGNSLETVSSKIIVTQTIKSKKDFSGPKSKKAHETKAEIIARENKKRLFAREEQKEEQKWNALSFSIEEQLKENLHSGIKSLEDFLKSCKSSCVKLQVEMVGLTACLKAWKEHCRSEEGKTTKDLSIAVQVMKRIHSLMEKYSELLQEDDRQLIARCLKYLGFDELASSLHPAQDAENDVKVKKRNKYSVGIGPARFQLQYMGHYLIRDERKDPDPRVQDFIPDTWQRELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLKESDDGVVVYVAPTKALVNQVAATVQNRFTKNLPSGEVLCGVFTREYRHDALNCQVLITVPACFEILLLAPHRQNWVKKIRYVIFDEVHCLGGEIGAEIWEHLLVMIRCPFLALSATISNPEHLTEWLQSVKWYWKQEDKIIENNTASKRHVGRQAGFPKDYLQVKQSYKVRLVLYGERYNDLEKHVCSIKHGDIHFDHFHPCAALTTDHIERYGFPPDLTLSPRESIQLYDAMFQIWKSWPRAQELCPENFIHFNNKLVIKKMDARKYEESLKAELTSWIKNGNVEQARMVLQNLSPEADLSPENMITMFPLLVEKLRKMEKLPALFFLFKLGAVENAAESVSTFLKKKQETKRPPKADKEAHVMANKLRKVKKSIEKQKIIDEKSQKKTRNVDQSLIHEAEHDNLVKCLEKNLEIPQDCTYADQKAVDTETLQKVFGRVKFERKGEELKALAERGIGYHHSAMSFKEKQLVEILFRKGYLRVVTATGTLALGVNMPCKSVVFAQNSVYLDALNYRQMSGRAGRRGQDLMGDVYFFDIPFPKIGKLIKSNVPELRGHFPLSITLVLRLMLLASKGDDPEDAKAKVLSVLKHSLLSFKQPRVMDMLKLYFLFSLQFLVKEGYLDQEGNPMGFAGLVSHLHYHEPSNLVFVSFLVNGLFHDLCQPTRKGSKHFSQDVMEKLVLVLAHLFGRRYFPPKFQDAHFEFYQSKVFLDDLPEDFSDALDEYNMKIMEDFTTFLRIVSKLADMNQEYQLPLSKIKFTGKECEDSQLVSHLMSCKEGRVAISPFVCLSGNFDDDLLRLETPNHVTLGTIGVNRSQAPVLLSQKFDNRGRKMSLNAYALDFYKHGSLIGLVQDNRMNEGDAYYLLKDFALTIKSISVSLRELCENEDDNVVLAFEQLSTTFWEKLNKV
Protein: Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) (Q05909)
Organism: Mus musculus (Mouse)
Function: Possesses tyrosine phosphatase activity.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Contactin-4
- Contactin-6
- Contactin-3
- Contactin-5
- Contactin-1
- Tyrosine-protein phosphatase non-receptor type 14
Sequence:
MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGTLQESRQDSSVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGSHQSPIDILDHHARVGDEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSVNGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFILRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQALNDRVVSKSAVRDAWNHDLADFLDNPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPTASAASKQAGRTVLATTEALASPGPDVHSAPSKDSEGTEEGEKEEKSESEDGEREHEEEEKDSEKKEKSEATHTAAESDRTAPAPTPSSPHRTAAEGGHQTIPGRRQDHSAPATDQPGHVAPDLDPLVDTATQVPPTATEEHYSGSDPRRPEMPSKKPMSRGDRFSEDSKFITVNPAEKNTSGMLSRPSPGRMEWIIPLIVVSALTFVCLVLLIAVLVYWRGCNKIKSKGFPRRSREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESVPIIPIPDDMEAIPVKQFGKHIGELYSNSQHGFSEDFEEVQRCTADMNITAEHSNHPDNKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIIMITNLVEKGRRKCDQYWPTENTEEYGNIIVTLKSTKVHACYTVRRLSVRNTKVKKGQKGNPKGRQNERTVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPDMGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETAVSSSQLHSYVNSILIPGVGGKTRLEKQFKLITQCNAKYVECFSAQKECNKEKNRNSSVVPAERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFVYKAMLSLISTKENGNGPMTGDKNGAVLTAEESDPAESMESLV
Protein: C3H1-type domain-containing protein (Q587D8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRPEQCDTYTELSSAPRETKVICKYFATGGCSRGAACAFSHVLNQNAPEGVDASRGFFICGNVANFGRTTALPTTQSVLSLPPSTTPEDSSILVEQMCAGAQQLHAPTAEPKLTPTIPSLPTIVDAGTARATYSSIPPERSLICCEESWMPQQRPLVPLNHSPVVHFVAPPPAMAFYHPMPYVLVGQVPLGYSLQGSTVNITRAN
Protein: G-protein coupled receptors family 1 profile domain-containing protein (Serotonin receptor) (G5ECV2)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MGIYHFNGVALFLLPVLCLIGLIGNFLVCVAIATDRRLHNVTNYFLFSLALADLLVCCIVMPLSIVVEVRHGVWTWSVSMCLLYVYSDVFLCSASIVHMSVISLDRYLGISQPLRTRNRSKTLIFIKIAIVWVVTLLVSCPIAVLAMHDTANILRNNQCMIFSRYYIIYGSTMTFLIPLCIMGVTYAKTTQLLNKQASILSQKAGDKFNGNGLRRTMPHRKLGYARTYSATVNGTIANGKAIGAHGRTMSSISNIANGETADRLGTSRPSINTNGHKQLQKASTINKWKSRTSNLVTNFANKVGRRSSLQTATQDLANEHKATRVLAVVFACFFICWTPFFFINFLIGFGGENVQIPDWVASIFLWLGYVSSTINPIIYTVFNKRFRQAFVRILRCQCFHPLRDSHQMYSRNFTTTIVPDTYTCSRSNQERTTSVITRDETRSARSSERPEPSRARSEISEEPVARTNGKLTSEKKKISLPSFPRVSSSRDSRATTEASTTDEETKPLIPKSTVPATVINIPEQLINPIKKSLTTIINMPLLDETIPEKAQVHHKSQTLLTSSTLNFATFSTCPQQPTRSYSCVDCKKAEKMLSSDVSDMMTTSTASTASTVNGAPRKHLTLFNHFDSAIKETFL