wanglab/gogpt-training-data huggingface dataset:
Protein: Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) (Q2M2R8)
Organism: Rattus norvegicus (Rat)
Function: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P50542}. Peroxisome matrix {ECO:0000250|UniProtKB:P50542}. Note=Cycles between the cytosol and the peroxisome matrix (By similarity). Following binding to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, recruited to the docking complex, composed of PEX13 and PEX14, leading to translocation into the peroxisome matrix along with cargo proteins. Export and recycling to the cytosol is initiated by binding to the PEX2-PEX10-PEX12 ligase complex via its unstructured N-terminus that inserts into the ligase pore and emerges in the cytosol (By similarity). Cys-11 of PEX5 is then monoubiquitinated, promoting its extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex (By similarity). Extraction is accompanied by unfolding of the TPR repeats and release of bound cargo in the peroxisome matrix. The TPR repeats refold in the cytosol and ubiquitination is removed by deubiquitinating enzymes, resetting PEX5 for a subsequent import cycle (By similarity). {ECO:0000250|UniProtKB:A0A1L8FDW4, ECO:0000250|UniProtKB:P50542}.
Interaction partners:
- Peroxisomal targeting signal 2 receptor
- Peroxisomal membrane protein PEX13
- Peroxisomal membrane protein PEX14
- Peroxisome assembly protein 12
- Peroxisomal ATPase PEX6
- Peroxisome biogenesis factor 10
- Next to BRCA1 gene 1 protein
- Serine-protein kinase ATM
- Alanine--glyoxylate aminotransferase
- Similar to peroxisome biogenesis factor 26.
Sequence:
MAMRELVESECGGANPLMKLATHFTQDKALRQEGLRPPWPPGASAAETVSKPLGVGTEDELVAEFLQDQNATLVSRAPQTFKMDDLLAEMQEIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVAQDYNETDWSQEFIAEVTDPLSVSPARWAEEYLEQSEEKLWLGDPEGTSTTDRWYDEYHPEEDLQHTASDFVSKVDDPKLANSEFLKFVRQIGEGQVSLESAAGSGRAQAEQWAAEFIQQQGTSEAWVDQFTRPGNKLAALQVEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSASYDKGYQFEEENPLRDHPQPFEEGLRRLEEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNRTALMALAVSFTNESLQRQACETLRDWLRYSPAYAHLVAPGEEGASGAGLGPSKRVLGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLPALLTMFGLPQ
Protein: Arp2/3 complex 34 kDa subunit (B5DGD5)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU364015}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 3 isoform X2
- Actin-related protein 3-like
- Actin-related protein 3
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit
- Actin-related protein 2/3 complex subunit 1B-like
- Actin-related protein 2/3 complex subunit
Sequence:
MILLEINNRIIEETLTLKFDSASNGTKPEAVEVTFADFDGVLYHISNPDGDKTKLMVSISLKFYKELQEHGADELLKRVYGNFLVSPEECYNVSLLFDLDAVPANKEEVIHQAGMLKRNCFASVFEKYFKFQEEGKEGEKRAVVHYRDDESMYLEAKKDRVTVVFSTVFKDDDDVILGKVFMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNANARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTMSGKTFSR
Protein: WPP domain-containing protein 1 (MFP1 attachment factor 1) (Q9FMH6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates the mitotic activity in roots. Plays a role with HSP70-1 in facilitating WIT1 nuclear envelope targeting.
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:15548735}. Cytoplasm {ECO:0000269|PubMed:15548735}. Nucleus {ECO:0000269|PubMed:15548735}. Golgi apparatus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Associated to the nuclear envelope (NE) in undifferentiated cells of the root tip. Associated with the outer NE and the nuclear pores in interphase cells and with the immature cell plate during cytokinesis. In differentiated cells, localized in both cytoplasm and nucleus. Accumulate in speckles of the cytoplasm belonging to the Golgi apparatus (By similarity). Appears at the NE as cells reenter the cell cycle during dedifferentiation. {ECO:0000250}.
Interaction partners:
- WPP domain-associated protein
- AT3g52230/F4F15_340
- Early endosome antigen
- At1g68680
- Expressed protein
- WPP domain-interacting tail-anchored protein 1
- At4g16450
- At3g49350
- V-type proton ATPase subunit c3
- Protein KINASE OF THE OUTER CHLOROPLAST MEMBRANE 1
Sequence:
MAETETESITTSSPPPISETENSTTLPTTETEKNPNPVTISLRIWPPTQKTRDAVINRLIETLSTESILSKRFGSLESEEASSVAKSIEDEAYAIASATVFGDDDGIEILKAYSKEISKRMLESVKAKSNVASPPPKDGDGIESAVDSKIDSSEA
Protein: Periphilin 1 (F8VPY7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAYRRDEMWSEGRYEYERIPRERAPPRSHPSDGYNRLVNIVPKKPPLLDRPGEGSYNRYYSHVDYRDYDEGRSFSHDRRSGPPHRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSY
Protein: TATA-box binding protein (Q7Z6S4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPIT
Protein: DNA polymerase delta 3, accessory subunit (H0YD46)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVVLDMQSHSLDILEHYVEMPIQRLER
Protein: Ferric uptake regulation protein (Ferric uptake regulator) (P0C631)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- DUF1882 domain-containing protein
- DNA-directed RNA polymerase subunit alpha
- Glutamate synthase large chain
- Serine hydroxymethyltransferase
- Lysine--tRNA ligase
- Colicin V production protein homolog
- Shikimate dehydrogenase
- Transmembrane protein
- Flagellar basal-body rod protein FlgC
- Thioredoxin
Sequence:
MLIENVEYDVLLERFKKILRQGGLKYTKQREVLLKTLYHSDTHYTPESLYMEIKQAEPDLNVGIATVYRTLNLLEEAEMVTSISFGSAGKKYELANKPHHDHMICKNCGKIIEFENPIIERQQALIAKEHGFKLTGHLMQLYGVCGDCNNQKAKVKI
Protein: H(2):CoB-CoM heterodisulfide,ferredoxin reductase subunit B (EC 1.8.98.5) (CoB--CoM heterodisulfide reductase subunit B) (Q50755)
Organism: Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
Interaction partners:
- F420-non-reducing hydrogenase subunit G
- H
- F420-non-reducing hydrogenase iron-sulfur subunit D
- H
- F420-non-reducing hydrogenase subunit A
- Energy-converting hydrogenase A, subunit Q
- Methyl viologen-reducing hydrogenase, subunit D-related protein
- formate dehydrogenase
- Molybdenum-containing formylmethanofuran dehydrogenase 1 subunit C
- Formate dehydrogenase, alpha subunit
Sequence:
MEIAYFLGCIMNNRYPGIEKATRVLFDKLGIELKDMEGASCCPAPGVFGSFDKTTWAAIAARNITIAEDMGADIMTECNGCFGSLFETNHLLKEDEEMKAKINEILKETGREYKGEVNVRHFAEVLYNDVGLDKLSELVEKPLNLNVAVHYGCHFLKPSDEINIDNPERPTILDEIVEVTGAKSVEYKDKMMCCGAGGGVRSRDLDVALDFTREKLTNMKEAGVDAIVNVCPFCHLQFDVGQMEIKDKFGEEFDIPVLHLAQLLGLAMGLPKEDLVVDAHQVCVDECLEKLEELDRLAPGSG
Protein: Tryptamine 5-hydroxylase (EC 1.14.-.-) (Cytochrome P450 71P1) (Protein SEKIGUCHI LESION) (Q2QUC5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in serotonin biosynthesis. Catalyzes the conversion of tryptamine to serotonin. Accumulation of serotonin may play a role in innate immunity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:20150424}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Nitrate reductase 1
- Nitrate reductase
- Nitrate reductase
- 4-coumarate--CoA ligase
Sequence:
MELTMASTMSLALLVLSAAYVLVALRRSRSSSSKPRRLPPSPPGWPVIGHLHLMSGMPHHALAELARTMRAPLFRMRLGSVPAVVISKPDLARAALTTNDAALASRPHLLSGQFLSFGCSDVTFAPAGPYHRMARRVVVSELLSARRVATYGAVRVKELRRLLAHLTKNTSPAKPVDLSECFLNLANDVLCRVAFGRRFPHGEGDKLGAVLAEAQDLFAGFTIGDFFPELEPVASTVTGLRRRLKKCLADLREACDVIVDEHISGNRQRIPGDRDEDFVDVLLRVQKSPDLEVPLTDDNLKALVLDMFVAGTDTTFATLEWVMTELVRHPRILKKAQEEVRRVVGDSGRVEESHLGELHYMRAIIKETFRLHPAVPLLVPRESVAPCTLGGYDIPARTRVFINTFAMGRDPEIWDNPLEYSPERFESAGGGGEIDLKDPDYKLLPFGGGRRGCPGYTFALATVQVSLASLLYHFEWALPAGVRAEDVNLDETFGLATRKKEPLFVAVRKSDAYEFKGEELSEV
Protein: SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) (Q6ZMT1)
Organism: Homo sapiens (Human)
Function: Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8R1B0}. Cell membrane {ECO:0000250|UniProtKB:Q8R1B0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1B0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R1B0}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q8R1B0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1B0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R1B0}. Note=Colocalizes with CACNA1C at the plasma membrane of transfected cells. {ECO:0000250|UniProtKB:Q8R1B0}.
Interaction partners:
- Voltage-dependent L-type calcium channel subunit alpha-1S
Sequence:
MTEMSEKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI
Protein: Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) (Q726Y7)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Pyruvate:ferredoxin oxidoreductase
- Malate synthase G
- Acetate kinase
- Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha
- Phosphate acetyltransferase
- Succinate--CoA ligase subunit alpha
- Pyruvate ferredoxin oxidoreductase, alpha subunit
- AMP-binding protein
- Citramalate synthase
- 2-isopropylmalate synthase
Sequence:
MSQERIESMMDEKRHFAPPADSRGRAHVSGEAAREALVRRAAEDPEGFWGERAAQLIDWFKPWDTVLDADMNEPRIEWFKGGRLNVAHNCLDRHVAGNRRNKAAIIWQGEPEEDVRVLTYQMLYDEVRRFAAVLRKMGVHKGDRVSLYMPMIPELAVAMLACARIGAVHSIVFAGFSAVSLQNRIHDCEAKVVVTADAVLRAGRRIPLKVNVDEAVRQCPSVEKVVVVNRGSLEVTMEEGRDLWWHEVMADRTLDVDRPCEEMDAEDMLFILYTSGSTGKPKGVVHTTGGYLTYAAHTTQWVFDVQDDDVYWCTADIGWITGHSYIVYGPLALGATSLMFEGVPSWPSPDRFWRIVEKFRVNIFYTAPTVVRALMREGTDWTERHDLSSLRVLGSVGEPINPEAWMWYHTHIGKGRLPIVDTWWQTETGGIMISGLPYATTLKPGSATQPLPGVDAAIVRPDGSPAGPNEGGHLVIRKPWPGMLRGIFGSPERYRSTYFERFPGMYESGDGARTDTDGYFWIMGRLDDVINVSGHRMGTAEVESALVAHPSVAEAAVVGMPHAVKGEAIYAYVTLGADAEETEELRAELRAWVRKEIGPIATPDVLQFAEGLPKTRSGKIMRRILRKIAAGATSEFGDTSTLADPGVVSDLIEGRLQLTGR
Protein: Small ribosomal subunit protein uS11m (37S ribosomal protein S18, mitochondrial) (YmS18) (P42847)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein bS6m
- Small ribosomal subunit protein mS47
- Small ribosomal subunit protein uS8m
- Small ribosomal subunit protein uS17m
- Small ribosomal subunit protein uS4m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS19m
Sequence:
MLLQPVWKGCRWTQFVRPIRRWNSTGTNRGVPFSFKDISNQEDITNISYPSSSDSVLTKSNGSSEVYKPKEEVVKYILHGKFTKNNTHLTFSSVVEDKNFHKNKGLTYNDTMLYYLNLPQKVKISLSTGCLGFRKAARGEYEAAFQTSGRMFELIKEKNMLNKDIEVVMDDFGKGRAAFISALVGKEGASVVKKVVKISDATKLKFGGVRSPKMRRL
Protein: N-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2) (Q93015)
Organism: Homo sapiens (Human)
Function: N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10644992, ECO:0000269|PubMed:30028079}.
Interaction partners:
- Profilin-1
- Actin, cytoplasmic 1
- Actin, alpha skeletal muscle
- Glycine N-acyltransferase-like protein 1
- N-alpha-acetyltransferase 60
- N-alpha-acetyltransferase 40
- N-alpha-acetyltransferase 10
- Profilin-2
- N-acetyltransferase ESCO1
- N-acetyltransferase ESCO2
Sequence:
MELILSTSPAELTLDPACQPKLPLDSTCQPEMTFNPGPTELTLDPEHQPEETPAPSLAELTLEPVHRRPELLDACADLINDQWPRSRTSRLHSLGQSSDAFPLCLMLLSPHPTLEAAPVVVGHARLSRVLNQPQSLLVETVVVARALRGRGFGRRLMEGLEVFARARGFRKLHLTTHDQVHFYTHLGYQLGEPVQGLVFTSRRLPATLLNAFPTAPSPRPPRKAPNLTAQAAPRGPKGPPLPPPPPLPECLTISPPVPSGPPSKSLLETQYQNVRGRPIFWMEKDI
Protein: Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) (Q14D04)
Organism: Homo sapiens (Human)
Function: Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26039994}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9VS24}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9VS24}.
Interaction partners:
Sequence:
MHQLFRLVLGQKDLSRAGDLFSLDDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPFGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNTMLLRVLPAVYEKQPQPINRHLTELLALMSQLEQPEQYHLLRLLHVAAKKKQLEVVQKCIPFLIGHLKDSTHNDIILNILIEIAVYEPVALNSFLPMLKEIGERFPYLTGQMARIYGAVGHVDEERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETAMMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVAVAQAKERESREVTTYL
Protein: Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) (P62718)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q02543}.
Interaction partners:
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL13
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL5
Sequence:
MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAAGKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF
Protein: Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) (S6CMQ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR000929}.
Interaction partners:
Sequence:
MVRWFHPNITGIEAEHLLLTRGVHGSFLARPSKSNPGDFTLSVRRNDEVTHIKIQNSGDYYDLYGGEKFATLAELVQYYTEQHDLLRERNGDVIELKYPLNCKDPTSERWYHGHLSGRDAEKLLTEKGKSGSFLVRESQSKPGDFVLSVLTNEEKHENVDRKTKVTHVMIRYQDGKYDVGGGERFDTLADLVEHYKKNPMVEKSGIVVHLKQPFNATRINAANIENRVHELNKVADNSEKPKQGFWEEFEVLQQQECKLLYPRKEGQRPENKNKNRYKNILPFDTTRVQIKEADPDVPGSDYINANYIRSVNEEGRHMDEGKVFIATQGCLQNTVLDFWKMVYQENTHVIVMTTKEMERGRNKCVRYWPDLNSTKEFGKVCVKNIEEHTAQDYIRRELEVTRLDRREPPRCIWHYQYLSWPDHGVPNEPGGVLSFLEQVNRTQSAIPESGPIVVHCSAGIGRTGTIIVIDILIDIINRQGLDCDIDIPKTIQRVRQQRSGMVQTEAQYKFIYMAVQQYIDTAQKRLEEEQRNKTKEREYSNIKYPQMSNARAKPNMSSSRSSSVMNDDSSVYENLNIKNPKGSTSSNTRR
Protein: Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (EC 1.1.1.300) (NADPH-dependent carbonyl reductase) (CR) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (Short chain dehydrogenase/reductase family 25C member 2) (Protein SDR25C2) (Q8VID1)
Organism: Rattus norvegicus (Rat)
Function: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds.
Subcellular location: Peroxisome {ECO:0000250|UniProtKB:Q8WNV7}.
Interaction partners:
- Aldehyde dehydrogenase 1A1
- All-trans-retinol 13,14-reductase
- Dehydrogenase/reductase SDR family member 9
- Retinaldehyde dehydrogenase 3
- Cytochrome P450 26A1
- Aldehyde oxidase 1
- Dehydrogenase/reductase
- Retinal dehydrogenase 2
- Lecithin retinol acyltransferase
- Beta,beta-carotene 15,15'-dioxygenase
Sequence:
MQKAGLLLRGWTRAWKSVRMASSGLTRQNPLANKVALVTASTDGIGLAIARRLAEDGAHVVISSRKQQNVDRAVATLQGEGLSVTGVVCHVGKAEDREKLVNMALKLHQGIDILVSNAAVNPFFGNLMDVTEEVWNKVLSINVTASAMMIKAVVPAMEKRGGGSVVIVSSVAGFVLFPSLGPYNVSKTALLGLTKNFAAELAPKNIRVNCLAPGLIKTHFSSVLWKEKAREEMIKETMQIRRLGKPEDCVGIVSFLCSEDASYINGETVVVGGGTPSRL
Protein: Hemoglobin subunit mu (Hemoglobin mu chain) (Mu-globin) (Q6B0K9)
Organism: Homo sapiens (Human)
Interaction partners:
- Hemoglobin subunit delta
- Hemoglobin subunit gamma-2
- Hemoglobin subunit beta
- Hemoglobin subunit gamma 1
- Hemoglobin subunit theta-1
- Alpha-hemoglobin-stabilizing protein
- Hemoglobin subunit epsilon
- 5-aminolevulinate synthase, erythroid-specific, mitochondrial
- Protein 4.2
- Hemoglobin subunit zeta
Sequence:
MLSAQERAQIAQVWDLIAGHEAQFGAELLLRLFTVYPSTKVYFPHLSACQDATQLLSHGQRMLAAVGAAVQHVDNLRAALSPLADLHALVLRVDPANFPLLIQCFHVVLASHLQDEFTVQMQAAWDKFLTGVAVVLTEKYR
Protein: Histone deacetylase 6 isoform B (Histone deacetylase 6, isoform B (EC 3.5.1.98)) (Q8IR38)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLRDIWIQSPPIVTRRSAQQAKIQTRAMASKSKTGTTGAATAAGGTGSSSGSISGGFNAADPRKSNKPNAALLEAKRRARNNMLKNQGCGSQESVTDIFQNAVNSKSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKEEDLHTVLRHWIGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGRRLPRDPVVGENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGDERPSGSKPKVKVKTLSDYLAENKEALEQSEMFAVYPLKTCPHLRLLRPEEAPRSLDSGAECSVCGSTGENWVCLSCRHVACGRYVNAHMEQHSVEEQHPLAMSTADLSVWCYACSAYVDHPRLYAYLNPLHEDKFQEPMAWTHGCAWREDGCYATGPDGRDEDDDDDNGAGSSICLRLERNN
Protein: Interferon gamma (IFN-gamma) (P17773)
Organism: Ovis aries (Sheep)
Function: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01579}.
Interaction partners:
- Interferon gamma receptor 1
- Fibronectin type-III domain-containing protein
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Interleukin-13
- Interleukin-10
- T-cell surface glycoprotein CD4
- Interleukin-1 beta
- Interferon alpha/beta receptor 1
- Interleukin-5
Sequence:
MKYTSSFLALLLCVLLGFSGSYGQGPFFKEIENLKEYFNASNPDVAKGGPLFSEILKNWKEESDKKIIQSQIVSFYFKLFENLKDNQVIQRSMDIIKQDMFQKFLNGSSEKLEDFKRLIQIPVDDLQIQRKAINELIKVMNDLSPKSNLRKRKRSQNLFRGRRASM