wanglab/gogpt-training-data huggingface dataset:
Protein: Protein kintoun (Dynein assembly factor 2, axonemal homolog) (PP1-interacting protein 20) (Q0E9G3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03069}.
Interaction partners:
- RuvB-like helicase 1
- RuvB-like helicase 2
- Dynein axonemal assembly factor 4
- Nucleolar protein 58
- AT03545p
- AT12351p
- IP21091p
- Dynein axonemal assembly factor 5
Sequence:
MSASRSRNKQSKLCDDERLDISRDEFNRFQEAFGKEEFRKLFFDYVDEIQDPENRKIYESEITQLEKERGVEVRFIHPKPGFVIKTALDGELKCFINIASCEEIQRPKNEVATDPSSGSRGLSWSIPMAQTTSRDDFDAKNNHCKVFDVVFHPDALHLAMRNKQFRQCLIDTALDAIEREYKVSLDRANLKFPKLDYKGIPRPTVIRKMADNPTAEEQEPHPLAHMFPTKPPAPGKQEPRVLPMKTKPSPVPEFTVPRYTIKHSHDVDLSEYTDELDAKLHVTVPRSLVVEIELPLLRSTAECQLDVTSKSIYLFSERQGAKYRLKLDLPFIVDDKAGRARFDTDMRRLSITLPVVRKSIQEQAQMHETLRHFSREDSGVELHSNSESPVEEDPDGELSDSKADISETSSPSVAPANSPFLKSSVHYQLPSKFDCNVLDNVMAFVLHVPNVQPDSIEQLREQRSLHLKFATIGSGYYPTHYAFYVELSAEHEDSSIESAEAEAWDNNVVLKLCLNSQSETPASYLAGLDATELKEYPVHGQYHVKSKGKVNAKKDNAPLDVKFERNQEGHALKVTIRPGTKEEEEDKENQDQEPESDQQQQQQVQNKKPGKKQRKKNKKERSLSESACADMILQEPLAKTNELQPRATFKLPPQRKQRSYSECNDSTGRSHRGILKRFSRYGPRPSMSDSWSSIDDSSSYSCSVDASGTSLFSQSFGGIPEEDRSDAGLSESCKKTVRFNDHIMKQVFRLDSSILGQRKKNQKRRDLKLRAQQRRLSEGDSVDYEETRGSALKQEENPSRNCNDSGLDLTGAAGAHSNNNESDAKNTMMFEMDD
Protein: Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) (P09572)
Organism: Gallus gallus (Chicken)
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P05023}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit beta-1
- FXYD domain-containing ion transport regulator
- Sodium/potassium-transporting ATPase subunit beta-3
- Protein ATP1B4
- Uncharacterized protein.
- cAMP-dependent protein kinase
- Sodium/potassium-transporting ATPase subunit beta
- FXYD domain-containing ion transport regulator
Sequence:
MGKGAGRDKYEPTATSEHGTKKKKAKERDMDELKKEISMDDHKLSLDELHRKYGTDLSRGLTTARAAEILARDGPNTLTPPPTTPEWVKFCRQLFGGFSLLLWIGSLLCFLAYGITSVMEGEPNSDNLYLGVVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVVRNGEKMSINAEGVVVGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPDFSNENPLETRNIAFFSTNCVEGTAVGIVISTGDRTVMGRIASLASGLEGGKTPIAMEIEHFIHLITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVGTLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGASFDKSSATWLALSRIAGLCNRAVFQANQENVPILKRAVAGDASESALLKCIELCCGSVKEMRERYPKVVEIPFNSTNKYQLSIHKNANAGESRHLLVMKGAPERILDRCDSILIHGKVQPLDEEIKDAFQNAYLELGGLGERVLGFCHLALPDDQFPEGFQFDTDEVNFPVEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISDGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILLHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTCTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVIMAENGFLPSGLVGIRLQWDDRWINDVEDSYGQQWTFEQRKIVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPYSLLIFLYDEIRKLIIRRNPGGWVERETYY
Protein: RNA exonuclease NGL1 (EC 3.1.-.-) (Q08213)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823961}.
Interaction partners:
- Poly
- Protein CAF40
- General negative regulator of transcription subunit 1
- Deadenylation-dependent mRNA-decapping factor PAT1
- Probable RNA exonuclease NGL3
- RNA exonuclease NGL2
- WW domain-containing protein WWM1
- General negative regulator of transcription subunit 3
- General negative regulator of transcription subunit 5
- General negative regulator of transcription subunit 2
Sequence:
MFTRRFIPVVQSTKQNIGKYVRKDARFTLLTYNMLSPSYMWPQVYTYVAEPYKNWSYRHRLLEKELLNTFKADIMCLQEMTARDYEDYWHDSIGVDVNYGSKFISKTPPKYWKKPVKDMDGVSIFYNLAKFDFISSSGIYLNQLLNVFNQRELKYLYNKKVTLTDGASNVIGEDSLLDVLKGKNQVCLFVSLRHKETGTIFVVLNTHLYWKYDEVKLTQCMIIMRELSKIIKQLLPGDVKGQERVKILFTGDLNSTRDSLVVNFLQGQIVSHGDLNLINPMRPYLDRCVYDDIPKDYFVHTCYSGKLKGIFDYVWYHDSDFLLTKILTGNEVSDELLASNQLGLPNENHPSDHIPLLTEFKIL
Protein: Alkaline phosphatase PhoV (APase PhoV) (EC 3.1.3.1) (Q55320)
Organism: Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2)
Function: Alkaline phosphatase with broad substrate specificity.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:8574398}; Lipid-anchor {ECO:0000269|PubMed:8574398, ECO:0000305}; Periplasmic side {ECO:0000269|PubMed:8574398}. Cell inner membrane {ECO:0000269|PubMed:8574398}; Peripheral membrane protein {ECO:0000269|PubMed:8574398}; Periplasmic side {ECO:0000269|PubMed:8574398}. Note=Associated with the periplasmic side of the inner membrane. {ECO:0000269|PubMed:8574398}.
Interaction partners:
Sequence:
MKIKLLCISLAVLFCSSANAQKKQAKVQPSVFPQTVARPKLVVGMVIDQMRWDYLYRFYARYGNGGFKRLINEGFSAENTLIPYTPTLTACGHSSIYTGSVPAINGIIGNNWFDPQLGRDVYCVEDKSVKTVGSSSNEGLMSPKNLLVTTVTDELRMATNFRSKVISVSIKDRGAILPGGHTANGAYWYDDMTGSFISSTHYMQQLPTWVNDFNAQRLPNKYFEQDWNTLYPIETYTESTADAKPYERTFKGAKTSSFPHLFKQYANKNYSMMASMPQGNSFTLEFAKAAIPAEKLGQTGNTDFLAVSLSSTDYVGHQFGPNSIELEDTYLRLDKDLEDFFNYLDKTIGKGNYLLFLTADHGATHVPGFLRNKMPGGRLLLKVQTDLDSLIFNEFKVRCNFTIINNQVIFDTDAIKEAKADYAKIKQSTIDYLVKQDGVLNAVDIKNMGAVTIPQEIKNKIINGYNARRSGDVYIILDAGWYPTLTPGTGHAAWNPYDSHIPALFMGWGVKPGKTNKEYYMSDIAPTVSALLHIQQPSGSIGKVITDLLK
Protein: Putative RNA exonuclease pqe-1 (PolyQ enhancer protein 1) (Q10124)
Organism: Caenorhabditis elegans
Function: Putative RNA exonuclease which protects neurons from the toxic effects of expanded poly-Q disease proteins. It is unknown whether this is via participation in the pathogenic mechanism underlying poly-Q-induced neurodegeneration or if it is by acting as a genetic modifier of the age of onset or progression of neurodegeneration. Regulates gene expression in neurons.
Subcellular location: [Isoform a]: Nucleus {ECO:0000269|PubMed:12486229, ECO:0000269|PubMed:22870397}. Note=Forms aggregates in the nucleus. {ECO:0000269|PubMed:22870397}.
Interaction partners:
- Probable oligoribonuclease
- Exonuclease domain-containing protein
- Exonuclease domain-containing protein
- Proliferating cell nuclear antigen
- PAN2-PAN3 deadenylation complex subunit PAN3
Sequence:
MFNGGYGSGNSFNLQNYAPIDPMTGIPGFGPSQNAQQQQQQASAPGTSSGGPSQAVSGASSGASMKTEPVARQVSTAQMKRDLEQAAVYVPTPIPEGSTQPQQRQQQQSQPQARQMSTQQAANLRKNAAAAGTPPKQAMQGASREQGNAHQPTAGQIPQSSNQPAQQTHNVPRMPQPLQQVPHPSPVRGSHPAAQQVQNAPQRIPQHVPMPQGVAPHQVIQQVRAPNIGASQMVQQAPSRGHTGAAPASRMAQQPVPLHQGVAPHQAAPQTIQQTPARGRPANAQLAQNAQQRNPQQVPMPQGVAPHHIPPQALGPHGAAPQMTQQAPARGPSGAAQHAQNAHRMTHQQVPLQAPVQGPHRGAPQMAQQPGPHGAAQHPSSGTVAPMHITSLPGNHPLNRTHLLFNRQVVPALDIRNLIAQHRLMVDDFVRAQICYRLPENHQDYWPPGGHPIPMQQQQMRQGAGLPNMAMPPPPLMRHPGPHQNPIHAMQSMQVQPPLSPDQMNMQMFQQRALMMQQQAMQMQMQNPPPVHQQPPPQQPPQQQRQKQQRSQPAPARVPPQVPSQVPVTGGVAADEPPPPCSYSPVAQSSESKIEPVDVKPRVAPVPPQVPVTPTKPVITNNKKKRIDVVTLDEDAPRRVQVKQEIPEVSSTSDATKSDAAPTARGAVRIKQEVESDVAPNTILISAKKFERMKAEAEDKEDMKKKIAALQEALFNIQEERRVEKEIAAFATTNQAVPQNQPASSVQIAQVSTSESDAPGTSEAAATETMTSPKTKNNVIVETEGEQEEDEDEIPIKKSKKRRAKIVSNDEEEEPVRHPKRRSDEKREKRHVSYAESDDDMPVVKKKRRNQSPEDPEYSAASPSEDEDDDIGSFVVSDNEDDDADSFVVGDDEPIEYEEEDEDDMIERRSSRKRRSDSRSKKSATPTDRRRSRDTPTGSRSMRSTSPNDRRKSRETPPGNRSMRRTSPSDGRKSRDTPTASSSMSSSTLSYCKKSKETPMSYEEIEQQKKAKRQRNCKTREENRERKRLAQLEELESSETTGVRRTLRSTQDNSDPLDASLATTIEEFRKTKKKDAKSSENRAKEKQKPMNKRPTSSASVDSNDDGVHIPAKRMAHASSVPGPSRSKPPMIGAVKNRPNHTEMLDKRNKESEEKRRKDRDELERLRNKKHTTEEEKIKMARLQNALKVVGKAAGLKATVKKELTGSPAKKQKPAPAVPKILDFSVGRTFTAIRQTAIKLVFDTFLERDSPNAAREAQEFELSIAKQYTDGQKYRINIGHKVAALRKENTSGILEVNKNAVSHDKILAGGPKDNCTVARGRKTHVDHRQLSIEKLHPLLLQFKLTTSELETNAYPMRRDGSTKAVSIADTVYTQNKKMFLDDYDMSRNCSRCNKEFKLSPNGTMIRSTGICRYHNRGVAINGKRDTFRKRYSCCNEEFNVALGCKFSDVHVTDQLFKKELSTFVSTPVPVPNDQRSTRVYALDCEMVYTIAGPALARLTMVDMQRNRVLDVFVKPPTDVLDPNTEFSGLTMEQINSAPDTLKTCHQKLFKYVNADTILIGHSLESDLKAMRVVHKNVIDTAILFRSTRDTKVALKVLSAKLLHKNIQGDNEDAIGHDSMEDALTCVDLIFYGLRNPESIAIREANTNC
Protein: Serine/threonine-protein kinase SULU (EC 2.7.11.1) (Protein kinase 18) (P46549)
Organism: Caenorhabditis elegans
Function: Acts as a negative regulator of cortical contractions during early embryonic cell division, possibly by regulating rho-1-dependent actomyosin contractility. Plays a role in polarity establishment in early embryos by regulating the size of the anterior and posterior cortex in the first asymmetric cell division. Might play a role in cell cycle progression. In the germline, involved in the regulation of meiotic progression during oogenesis, possibly by modulating the timing of mpk-1 activation. Plays a role in meiotic recombination events. Involved in pharyngeal pumping.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23064028}. Cytoplasm, cell cortex {ECO:0000269|PubMed:23064028}. Note=Localized to the anterior cortex in embryos; localization to the anterior cortex depends on par-3 and rho-1. {ECO:0000269|PubMed:23064028}.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase sek-1
- Uncharacterized protein
- F-box A protein
Sequence:
MAPAVLQKPGVIKDPSIAALFSNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLFSMNAMSALYHIAQNDPPTLSPIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKMRKLMYLDETEGKEGSEGNGASDDLDFHGNEANSIGRAGDSASSRSASLTSFRSMQSSGGAGLLVSTNTTGAMDNVHGSSGYGNGSSSTTSSARRRPPIPSQMLSSTSTSGVGTMPSHGSVGASITAIAVNPTPSPSEPIPTSQPTSKSESSSILETAHDDPLDTSIRAPVKDLHMPHRAVKERIATLQNHKFATLRSQRIINQEQEEYTKENNMYEQMSKYKHLRQAHHKELQQFEERCALDREQLRVKMDRELEQLTTTYSKEKMRVRCSQNNELDKRKKDIEDGEKKMKKTKNSQNQQQMKLYSAQQLKEYKYNKEAQKTRLRSLNMPRSTYENAMKEVKADLNRVKDARENDFDEKLRAELEDEIVRYRRQQLSNLHQLEEQLDDEDVNVQERQMDTRHGLLSKQHEMTRDLEIQHLNELHAMKKRHLETQHEAESASQNEYTQRQQDELRKKHAMQSRQQPRDLKIQEAQIRKQYRQVVKTQTRQFKLYLTQMVQVVPKDEQKELTSRLKQDQMQKVALLASQYESQIKKMVQDKTVKLESWQEDEQRVLSEKLEKELEELIAYQKKTRATLEEQIKKERTALEERIGTRRAMLEQKIIEEREQMGEMRRLKKEQIRDRHSQERHRLENHFVRTGSTSRSSGGIAPGVGNSSSIQMAM
Protein: Electrogenic sodium bicarbonate cotransporter 4 (NBCe2) (Solute carrier family 4 member 5) (Q9BY07)
Organism: Homo sapiens (Human)
Function: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:17715183, ECO:0000269|PubMed:26447209}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6RI88}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. {ECO:0000269|PubMed:17715183}.
Interaction partners:
- Centrosome-associated protein ALMS1
- Dynactin subunit 1
Sequence:
MKVKEEKAGVGKLDHTNHRRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKKPIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKETDKKRKRKKGAHEDCDEEPQFPPPSVIKIPMESVQSDPQNGIHCIARKRSSSWSYSL
Protein: Large ribosomal subunit protein uL29m (Q38EM7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- 50S ribosomal protein L17, putative
- Small ribosomal subunit protein uS5
- 60S ribosomal protein L17, putative
- 40S ribosomal protein S13, putative
- 50S ribosomal protein L2, putative
- 50S ribosomal protein L13, putative
- Ribosomal protein L11, putative
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein mL46
- 40S ribosomal protein S5, putative
Sequence:
MQRNLTKLSAAAFYEFVDNNFLNNKRPPVPGGSWTVEVLRNKSLADLQHIWFLLLKERNMLKSMKEHYLRHQEELGAMPAPSRLKMIDESMRNIKRVVKERDEEATARAVEIFKERLKRGIYRYPPGPPPPPGAHDKTSVVKVELSCYVEEERLRELFGRYDVFEPHKGIVRVELKLPDEVLKQKEEAEQLWTQYMAECSDVKAYHQWSTAAPSAYDYTEVELAPGIFANDAISDKGAKHSGDTETHEGVIVAARVPVPPPKEKQPPPKNPLERLKAERRSYLARTTIQLGYFPNVTLPPPRYETVEAVPRPVHPDEIEGPWEAYITYDREDGLSYAQSLGITTIGVATVLGLTEHVREPQPYAVVDPVYCEALRRERAREETLMKWPHVPEWKYEYSTYTRKHLADIVQYNYTNVVDYVDREVLLTGKSVWECPIHIDHTCGGSKTVPPHAKKPVRYMDAGIANVGVTDI
Protein: Thioredoxin M2, chloroplastic (AtTrxm2) (Q9SEU8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiol-disulfide oxidoreductase that may participate in various redox reactions. May activate NADP-malate dehydrogenase.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:19259774}.
Interaction partners:
- Ferredoxin-thioredoxin reductase catalytic chain, chloroplastic
- NADPH-dependent thioredoxin reductase 3
- 6-phosphogluconolactonase 3, chloroplastic
- Mitochondrial outer membrane protein porin 3
- Ferredoxin/thioredoxin reductase subunit A
- Thioredoxin-like protein CDSP32, chloroplastic
- Uncharacterized protein
- Kinesin-like protein KIN-14F
- 2-Cys peroxiredoxin BAS1-like, chloroplastic
- 2-Cys peroxiredoxin BAS1, chloroplastic
Sequence:
MAAFTCTSRPPISLRSETRIVSSSPSASSLSSRRMFAVLPESSGLRIRLSLSPASLTSIHQPRVSRLRRAVVCEAQETTTDIQVVNDSTWDSLVLKATGPVVVDFWAPWCGPCKMIDPLVNDLAQHYTGKIKFYKLNTDESPNTPGQYGVRSIPTIMIFVGGEKKDTIIGAVPKTTLTSSLDKFLP
Protein: Nudix hydrolase (AtNUDT) (EC 3.6.1.13) (EC 3.6.1.22) (ADP-ribose pyrophosphatase) (NADH pyrophosphatase) (F4JRE7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGTRAQQIPLLEGETDNYDGVTVTMVEPMDSEVFTESLRASLSHWREEGKKGIWIKLPLGLANLVEAAVSEGFRYHHAEPEYLMLVSWISETPDTIPANASHVVGAGALVINKNTKEVLVVQERSGFFKDKNVWKLPTGVINEELVVLRVVGELHKKVVLTSYRSIKCLLIICNDTKNETKRMGEDIWTGVAREVEEETGIIADFVEVLAFRQSHKAILKKKTDMFFLCVLSPRSYDITEQKSEILQAKWMPIQEYVDQPWNKKNEMFKFMANICQKKCEEEYLGFAIVPTTTSSGKESFIYCNADHAKRLKVSRDQASASL
Protein: Tubulin-specific chaperone A (B5G0F2)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|RuleBase:RU364030}.
Interaction partners:
Sequence:
MADPRLRQIKIKTGVVRRLAKEKIMYEKEAKQQEEKIEKMKAEACDDYGIKKQIEILQESRMMIPDCQRRLEVAHAELTQLLXK
Protein: Envelope small membrane protein (E protein) (sM protein) (P0C2R0)
Organism: Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus)
Function: Component of the viral envelope that plays a central role in virus morphogenesis and assembly. It is sufficient to form virus-like particles. Seems to be important for creating the membrane curvature needed to acquire the rounded, stable and infectious particle phenotype. Acts as a viroporin, inducing the formation of hydrophilic pores in cellular membranes. Also induces apoptosis.
Subcellular location: Host Golgi apparatus membrane {ECO:0000255|HAMAP-Rule:MF_04204}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04204}. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04204}.
Interaction partners:
Sequence:
MFNLFLTDTVWYVGQIIFIFAVCLMVTIIVVAFLASIKLCIQLCGLCNTLVLSPSIYLYDRSKQLYKYYNEEMRLPLLEVDDI
Protein: Alpha-1,3-galactosyltransferase 2 (EC 2.4.1.87) (Isoglobotriaosylceramide synthase) (iGb3 synthase) (iGb3S) (Q3V1N9)
Organism: Mus musculus (Mouse)
Function: Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Synthesis of iGb3 is the initial step in the formation of the isoglobo-series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids. Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids.
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:A0A4Z3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:A0A4Z3}. Note=Also found in numerous large vesicles throughout the cytoplasm of the soma. {ECO:0000250|UniProtKB:A0A4Z3}.
Interaction partners:
- UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
- Beta-1,4-galactosyltransferase 6
- Beta-galactosidase
Sequence:
MALGTELGVSWPGSHGSCREQEGQRQRGPGKPTWGLSRAKKRLLWRFFLSAFGFLGLYHYRFIIIRLIEGSIPMGTCPTAIMPLPRDNFTGVLHHWARPEVLTCTSWGAPIIWDGTFDPHVAQQEARRRNLTIGLTVFAVGRYLEKYLEHFLVSAEQHFMVGQNVVYYVFTDRPEAVPYVALGQGRLLRAKPVQRERRWQDVSMARMPTLHEALGGQLGQEADFVFCLDVDQYFTGNFGPEVLADLVAQLHAWHYRWPRWLLPYERDKRSAAALSLSEGDFYYHAAVFGGSVAALLKLTAHCATGQQLDHKRGIEALWHDESHLNKFFWLNKPTKLLSPEFCWAEEIIWRREIHHPRLLWAPKEYTLVRN
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (H7C2X4)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|PIRNR:PIRNR000543}.
Interaction partners:
Sequence:
MALRLLKLAATSASARVVAAGAQRVRGIHSSVQCKLRYGMWHFLLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGKPLATDYNGNCSLEKFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIRKQCVDHYNEVKSVTICDYLPPHLVIYIDVPVPEVQRRIQKKGDPHEMKITSAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAQDSKKVVEDIEYLKFDKGPWLKQDNRTLYHLRLLVQDKFEVLNYTSIPIFLPEVTIGAHQTDRVLHQFREFSLFNGRKPDAVKILCSLLEADRSLLEADRSLLEADRVQDSC
Protein: Flavohemoprotein (EC 1.14.12.17) (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) (P39676)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- mRNA-binding protein PUF3
- DNA repair protein RAD51
- Zinc finger protein FZF1
- Pentafunctional AROM polypeptide
Sequence:
MLAEKTRSIIKATVPVLEQQGTVITRTFYKNMLTEHTELLNIFNRTNQKVGAQPNALATTVLAAAKNIDDLSVLMDHVKQIGHKHRALQIKPEHYPIVGEYLLKAIKEVLGDAATPEIINAWGEAYQAIADIFITVEKKMYEEALWPGWKPFDITAKEYVASDIVEFTVKPKFGSGIELESLPITPGQYITVNTHPIRQENQYDALRHYSLCSASTKNGLRFAVKMEAARENFPAGLVSEYLHKDAKVGDEIKLSAPAGDFAINKELIHQNEVPLVLLSSGVGVTPLLAMLEEQVKCNPNRPIYWIQSSYDEKTQAFKKHVDELLAECANVDKIIVHTDTEPLINAAFLKEKSPAHADVYTCGSLAFMQAMIGHLKELEHRDDMIHYEPFGPKMSTVQV
Protein: FHL3 protein (Q96C98)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPKCSSCKRPIVGLGGGKYVSFEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQGCSQAGP
Protein: Sigma-O factor regulatory protein RsoA (C0H3R4)
Organism: Bacillus subtilis (strain 168)
Function: Together with RNA polymerase sigma factor SigO, positively regulates the expression of at least three operons, including oxdC-yvrL, sigO-rsoA and yvrJ. Required for the acid stress-dependent induction of the oxalate decarboxylase oxdC.
Interaction partners:
- RNA polymerase sigma factor SigO
- Membrane-bound negative regulator YvrL
- Oxalate decarboxylase OxdC
Sequence:
MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDLEQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS
Protein: Glutamate decarboxylase (GAD) (EC 4.1.1.15) (Q04792)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- 4-aminobutyrate aminotransferase
- NAD-specific glutamate dehydrogenase
- Succinate-semialdehyde dehydrogenase [NADP
- Aldehyde dehydrogenase [NAD
- Potassium-activated aldehyde dehydrogenase, mitochondrial
- NADP-specific glutamate dehydrogenase 2
- Aldehyde dehydrogenase [NAD
- NADP-specific glutamate dehydrogenase 1
- Fatty aldehyde dehydrogenase HFD1
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Sequence:
MLHRHGSKQKNFENIAGKVVHDLAGLQLLSNDVQKSAVQSGHQGSNNMRDTSSQGMANKYSVPKKGLPADLSYQLIHNELTLDGNPHLNLASFVNTFTTDQARKLIDENLTKNLADNDEYPQLIELTQRCISMLAQLWHANPDEEPIGCATTGSSEAIMLGGLAMKKRWEHRMKNAGKDASKPNIIMSSACQVALEKFTRYFEVECRLVPVSHRSHHMLDPESLWDYVDENTIGCFVILGTTYTGHLENVEKVADVLSQIEAKHPDWSNTDIPIHADGASGGFIIPFGFEKEHMKAYGMERWGFNHPRVVSMNTSGHKFGLTTPGLGWVLWRDESLLADELRFKLKYLGGVEETFGLNFSRPGFQVVHQYFNFVSLGHSGYRTQFQNSLFVARAFSFELLNSSKLPGCFEIVSSIHESIENDSAPKSVKDYWEHPQAYKPGVPLVAFKLSKKFHEEYPEVPQAILSSLLRGRGWIIPNYPLPKATDGSDEKEVLRVVFRSEMKLDLAQLLIVDIESILTKLIHSYEKVCHHIELASEQTPERKSSFIYEMLLALASPQDDIPTPDEIEKKNKLKETTTRNYRGTC
Protein: Candida glabrata strain CBS138 chromosome E complete sequence (Q6FVI0)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
Sequence:
MKFLLFAAVAQAYLQLDFERQTAQDVALAKRHTSNGVANAMDVPIEQIGDLMYTVQLHVGTPPQNVTVQLDTGSSDLWFPVASNPYCKRNAKLAPKKVKALPATGFATENDQVAKKLRTFDCDAFGLFNSSMSSSFKSNDSSEFFVKYEDGTYASGMWGTDTFKLNHHNVSNITFALANIANASMGVLGVGFPAEETTDDPSPGSLIDKEHYQYDNFPIALKRTRTIKKVSYSIFLNDTNSKKGVILFGGVDHSKYQGTLWTVPMVNNLLTLNQTTTSRPEITLNGLGFRDDKKNVTLWGEKIPVLLDTGTTLAYAPKQVVDVIAKRVNGTIDSKTGGIKLKKCPNAKDNSELIFNFAGAEIPVSLLNMVEKRKGKCYLEIRYHEELSKTGMLLGDIFMRHVYSVFNMEDMEVSFAVANGNDSAPLQIEAIISDVPSAVKAPQYYNTFASSNLPSTVTNDIFASTATASMEPPSSVLESLKSKSSSTSSIDTSVPSDDKKIIDDDHSGHDHAKRDAYSNTAGILQISTTLVLVAMTLLL
Protein: Semaphorin-6B (Semaphorin-Z) (Sema Z) (Q9H3T3)
Organism: Homo sapiens (Human)
Function: Functions as a cell surface repellent for mossy fibers of developping neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons.
Subcellular location: Cell membrane {ECO:0000269|PubMed:32302524}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Plexin-A2
- Plexin-A4
- Ena/VASP-like protein
- Plexin-A3
Sequence:
MQTPRASPPRPALLLLLLLLGGAHGLFPEEPPPLSVAPRDYLNHYPVFVGSGPGRLTPAEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCIFLSPGTRAAFEQDVSGASTSGLGDCTGLLRASLSEDRAGLVSVNLLVTSSVAAFVVGAVVSGFSVGWFVGLRERRELARRKDKEAILAHGAGEAVLSVSRLGERRAQGPGGRGGGGGGGAGVPPEALLAPLMQNGWAKATLLQGGPHDLDSGLLPTPEQTPLPQKRLPTPHPHPHALGPRAWDHGHPLLPASASSSLLLLAPARAPEQPPAPGEPTPDGRLYAARPGRASHGDFPLTPHASPDRRRVVSAPTGPLDPASAADGLPRPWSPPPTGSLRRPLGPHAPPAATLRRTHTFNSGEARPGDRHRGCHARPGTDLAHLLPYGGADRTAPPVP