wanglab/gogpt-training-data huggingface dataset:
Protein: Protocadherin gamma A9 (Protocadherin gamma subfamily A, 9) (Q91XX9)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MAAAPARRPHCRELVVLCALLGMLWEARAGQIRYSVPEETEKGYIVGNISKDLGLEPRELAERGVRIISKGKTQLFSLSPRSGSLVTAGRIDREELCAQSATCLLNFKVLVEDRVKLYGVEVEVVDINDNAPKFEAENLFVKISEIAAPGARYPLPEAVDPDVGINSLQSYQLSPNRHFSLHLQTGDDGTINPELVLERTLDREEEPTHHLVLTAYDGGNPRRSSTALIQVTVLDTNDNAPVFDQPVYRVKVLENVAPGTLLLTVRASDPDEGANGKVTYKFRKINEKHSLLFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDGGGLKGRTKVVVMVEDVNDNRPEVTITSLFSPVREDAPPGTVILLFNAHDQDSGKNGQVVCSIQENPSFKLENSVDDYYRLLTAQILDREKASEYNITVTATDRGTPSMSTEVHITLYVADINDNPPAFSQTSYSVYLPENNPRGTSIFSVSAHDPDDEENAKVTYSLVENTIQGAPLSSYVSINSDTGVLYALQSFDYEQFQNLQMQVKASDNGHPPLSSNVSLSVFLLDQNDNAPKILYPSLPTDGSTGVELAPRSAEAGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFTVGLRSGEIRTARALLERDALKQSLVVAVQDHGQPPLSATITLTVAVADSIPDILADLGSINTPADPDSDITLYLVVAVAVVSCVFLLFVLVLLALRLRRWHASHLLQDAMGGSTGVPTSHIVGVHGVQTFLQTYSQEFSLTPDSGKSHLIFPQPNYADTLISQESCGKSEPLCSSVEPKFPIDDTPLVPQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Protein: Gp108 (A8ASU2)
Organism: Listeria phage A511 (Bacteriophage A511)
Interaction partners:
Sequence:
MSRYDHSTVEYTDKIKDLTDSVNRVGNYLSGDNSPYDDVQKLKAITQNIKLTKDTGLAKSITAGTTALRSVVEVGVYYINSTEALALTDKPPELTGAFILVNYPTTASTSVKQEVHMFATGTTGSYVGYRWISASSVSSWWTYENTLGSQAKADKALADGKTYTDSSVNSALQAIQNSAQMYKLTADDGKPIDASAMATPPTSVASLTKTGIYYFTAAFGNTMPDTPCTGQPFWLVVLQHVTDNSISQSVTANTVEVERVVADRIITTLGVPSKWEYRAKASNFFFSASNSSRITLVSTQQNIITPNKFINNPDSLPLSAINPAITIPEDGMYQVMVTLNINGILEKVYLVSELTLLVNDVVHPATFGMVKTVDNANGQYSLAGNGIYQLKKGDKLKLRSYCNNTGNNPYLDVDKLYISVGKIADISLFK
Protein: Amino acid permease 1 (Amino acid transporter AAP1) (Neutral amino acid transporter II) (Q42400)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Amino acid-proton symporter. Stereospecific transporter with a broad specificity for histidine, glutamate and neutral amino acids. Reduced affinities for asparagine and valine. Involved in amino acid uptake from the apoplastic cavity into the embryo cells for storage protein accumulation and in root amino acid uptake.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17419840}; Multi-pass membrane protein {ECO:0000269|PubMed:17419840}.
Interaction partners:
- Cationic amino acid transporter 6
- Cationic amino acid transporter 9
- WAT1-related protein At1g44800
- WAT1-related protein At4g01430
- WAT1-related protein At1g01070
- WAT1-related protein At1g09380
- WAT1-related protein At2g39510
- WAT1-related protein At2g40900
- WAT1-related protein At3g28100
- Probable polyamine transporter At3g13620
Sequence:
MKSFNTEGHNHSTAESGDAYTVSDPTKNVDEDGREKRTGTWLTASAHIITAVIGSGVLSLAWAIAQLGWIAGTSILLIFSFITYFTSTMLADCYRAPDPVTGKRNYTYMDVVRSYLGGRKVQLCGVAQYGNLIGVTVGYTITASISLVAVGKSNCFHDKGHTADCTISNYPYMAVFGIIQVILSQIPNFHKLSFLSIMAAVMSFTYATIGIGLAIATVAGGKVGKTSMTGTAVGVDVTAAQKIWRSFQAVGDIAFAYAYATVLIEIQDTLRSSPAENKAMKRASLVGVSTTTFFYILCGCIGYAAFGNNAPGDFLTDFGFFEPFWLIDFANACIAVHLIGAYQVFAQPIFQFVEKKCNRNYPDNKFITSEYSVNVPFLGKFNISLFRLVWRTAYVVITTVVAMIFPFFNAILGLIGAASFWPLTVYFPVEMHIAQTKIKKYSARWIALKTMCYVCLIVSLLAAAGSIAGLISSVKTYKPFRTMHE
Protein: Beta-lactamase (EC 3.5.2.6) (Ambler class A beta-lactamase) (P9WKD3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta-lactam ring. Displays high levels of penicillinase and cephalosporinase activity as well as measurable activity with carbapenems, including imipenem and meropenem. Plays a primary role in the intrinsic resistance of M.tuberculosis to beta-lactam antibiotics.
Subcellular location: Cell inner membrane {ECO:0000303|PubMed:15699201}. Periplasm {ECO:0000305|PubMed:16267291}. Secreted {ECO:0000250|UniProtKB:A5U493}.
Interaction partners:
- Uncharacterized protein Rv2067c
- Serine protease inhibitor Rv3364c
- Probable lipase LipD
Sequence:
MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLHQNPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDAEEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPREALLAEAATCVAGVLA
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (C9J383)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDSKYRGHLILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLR
Protein: MICOS complex subunit MIC60, mitochondrial (AtMic60) (Mitochondrial contact site and cristae organizing system 60 kDa subunit) (Mitofilin) (Q9ASV5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (By similarity). Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity). Involved in the maintenance of mitochondria morphology. Binds to glycerolipids such as cardiolipin (CL). Contributes to the export of phosphatidylethanolamine (PE) from mitochondria and to the import of galactoglycerolipids from plastids during phosphate (Pi) starvation. Promotes lipid desorption from membranes, likely as an initial step for lipid transfer, and regulates probably the tethering between the inner and outer membranes of mitochondria by binding to TOM40 proteins.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:26898467, ECO:0000269|PubMed:31118221}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- MICOS complex subunit Mic10-like protein
- Protein DGS1, mitochondrial
- SAP domain-containing protein
- Mitochondrial import receptor subunit TOM40-1
- Transducin family protein / WD-40 repeat family protein
- Transducin family protein / WD-40 repeat family protein
- Mitochondrial Rho GTPase 1
Sequence:
MLRKSVLELSSRLSIKRFPRNLGAQRFHLSSSRNASTSGKNGLPGAKPVGKPDASKVDPPKVTPPPPTKGNSSKVVIGGVAIAGAFLVAYQTGYLDQYLGKEQQKLSERIHSDALTEKLEEAHHLNVPSGVEDSTEKDGKVETQPQVTHSEASEGVQSDIELQPESDLSSDRFTYISSNQEETPQETVIDRAEINLPISASEDSGAKPDMPSEIISEAESVKLEAVPKPGDSPIIVNAQSSSVHRESETESASPKDPAALKTPEDGIEREVQLPGSLLKEYNLEGSDTESTGSSSIGEQITKETEAFPNSTEGLKDSYMTEDGKLVLDFLAAIHAAEKQQAHLDAQVFAEELRALKEKYENELRDLRARELMRIEEAAILDKELKRERTKAAAAIKAIQERMEDKLKAELEQKETEAQLALSKAEELAKAEMISTIAKEKAAQIEKMAEADLNIKALSMAFYARSEEARQSHSVHKLALGALALDDTLSKGLPVQKEIDTLQTYLEGTHKDSILGLVLSSLPEEARSNGTDTVLQLNQKFDTLKGTLRHFSLIPPGGGGILAHSLAHVASSLKFKEVDQANGGIESVIKKVDNYLAEGKLAEAAATLEEGVKGSKAEEIVSDWVRRARNRAITEQALTLLQSYATCVSLT
Protein: Bitesize, isoform E (A8JR10)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKQVTRLIGPRRMASSKPKEAPSYNAFASASTSSKKSQPASTAPAPLARVHNYGRVKSQPAGSSLPSSSAGKIQYAALNRMRKKRSEDEGKKLKRKSKWRQLFGQCWWKKRRRQRSYQDYWSSSREKSKKSHFFCYCCRRRTNGYGYDSEEEDDDIDAKVASYIVEMKQREAAANGQSEILVEETPNPVPQEQVKQLPTQLRSPPIVKRRAWTWDDSLRSNSDRFLETLEDDLPVSSEEVVAAASGGRTSLILHRRTPLHVTFVENEEEQSEREDRQKQERVTVQEEAKVAAEELSRSPVIGQRQADGSGSPIQSRASSETWPTQSDEDIDRLVAMHQNRSSLSSLGVRSESMASVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLFDNPQSQWYLLQERSEPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEGSLVLRSSLDGIRANLP
Protein: Urokinase plasminogen activator (Q9TVA8)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
CLNGGKCVTYKYFSNIQRCSCPKKFQGEHCEIDTSKTCYQGNGHSYRGKANRDLSGRPCLAWDSPTVLLKMYHAHRSDAIQLGLGKHNYCRNPDNQRRPWCYVQIGLKQFVQFCMVQDCSVGKSPSSPREKEEFQCGQKALRPRFKIVGGQVTNAEN
Protein: Microspherule protein 1 (A0A8I6A524)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPKRRSSSRFIKRKKFDDELVESSLAKSSTRVKGAGSVESGRCSGSEPSSSEKKKVSKAPSTPVPPSPAPTPGLTKRVKKSKQPLQVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRFTLREVQERWYALLYDPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLSKVGSTSQPTLETFQDLLHRHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGDQVLNFSDAEDLIDDSKLNSLLPFHFTSELTVADRRQKREIRQLEQELHKWQVLVDSITGMSSPDFDNQTLAVLRGRMVRYLMRSREITLGRATKDNQIDVDLSLEGPAWKISRKQGVIKLKNNGDFFIANEGRRPIYIDGRPVLCGSKWRLSNNSVVEIASLRFVFLINQDLIALIRAEAAKITPQ
Protein: AUGMIN subunit 2 (O48767)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Contributes to the assembly of the acentrosomal spindle and phragmoplast microtubule arrays as part of the augmin complex.
Interaction partners:
- AUGMIN subunit 3
- AUGMIN subunit 1
- AUGMIN subunit 5
- AUGMIN subunit 4
- AUGMIN subunit 7
- AUGMIN subunit 6
- Ribonucleases P/MRP protein subunit POP1
- AUGMIN subunit 8
Sequence:
MSMGGDTTWVGKKPIRRIGGLSDALSIASDLGFAVAPPPSQEELQSFASSNGERGDDLIRVLRELSVVQRKIADLQVELQGRKDDKNVAHLTHVGEMQKKIETLSRITQILKDVIQNKDRIIARLQQPYSLDCIPVEAEYQKQFSELLMKAASDYGALTASVSDFQWSQNFKEPPSVWGEMLRPIPVALASCTRFFEAMSAMRESFATLQELRVGNSAVSLPTTPGGNEMTHRDSDCVTPPQGRIESSFDDLAVHKTRRQNNDQNEEEEEEEEEEDGNNNGNRRLSWPPSVKKSSV
Protein: Provisional ortholog of ankyrin repeat domain 52 L homeolog (Putative transient receptor potential channel) (Q4A520)
Organism: Xenopus laevis (African clawed frog)
Interaction partners:
Sequence:
MSLQDCLTALHVAAAHSKDEIVRLLLKKAEPNIPGGPKDQLPLHYTALRPNGAINVTQTLLRASHKDARLTPDKDGCIPLFLAIEAGNLGICKELLLVNPESQLRAVSKKYGDTALHASCRKRDVDAAKLLVEYGANVDCQNDEGQTPLHIVAWAGDEMMLKFLHQCKTNANITDKMERTPLHVAAERGNTNVVEILTEKFRSNVLARTKDGNTLMHIASQCGHPETALAFLKRGVLLHMPNKSGAVCLHAAAKRGHTAVVKALLQKGAHVDARTKDNYTALHVAAENCKPQVVQTLLGFGAQVQLKGGKAQETPLHVAARIKDGEKVAEMLIKSGADINVEQENGETAMHISAQHGNLKMITALIEEGGEPTWQSKNQENPLHTAVRHCHLPIVEVLLQHLINERGRADAVGCVNQANKAGETSLHLAAAVKKEMIHTKEEDVKIIGILMEHDGDISRPTNTTLETPLHYCARVGNEDVLLEMIRHISSSRMQQTMNKQAKNGRSPLLVAAEQGHTGIVRILLQNQARVDVFDEHGKAALHLAAENGHDKIADILLKHKAFVNAKTKLGLTPLHLCAQNGFNHLVKLLVGTHSASIDAMALTKRTPLHMAALNGQLDVCNSLLNMKADVNATDIEGQTPLHLAAENDHSEVVKVFLKHKPELVTSANMEGSTCAHIAASKGSAAVIKELLKFNKTGVTTARNKTNDSTPLHLAAAGGHTDVVKVLLETGALASDENGEGMTAIHLAAKNGHINVLEALKGSVSFRITSTKTGFTALHVAAHFGQLDFVREILTKVPATMTSEPPKAVPDLLHMKEQRGESGYTPLHLASQSGHESLVRLLLNYPGVQADTATTRQGSTPIHLAAQNGHTAVVGLLLSKSTSQLHMKDKRGRTCLHLAAANGHIEMMRALIGQGAEINVTDKNGWCPLHFAARSGFLDTVRFLVECGANPTLECKDGKTAIQYAAAKNHQDVVSFLLKKNHNTLKLIEDRKFVFDLMVCGKLNDNRIIQEFILNSSAPLDTAVKLSRALNITAFKEKERAMDLLNAAKYSENMATELLTIASGSTNAGFILRAVDHRCTTILDCLIECEQKDVVAHPAVQKYLTEVWYGNLDWTTWKLVLLFFTFLACPPVWLVFSLPLKHRFNKIPIMKFMSYLASHIFLIVLFILTIVYPPLSPIYEGHMVPCWNEWLLLAWLSGMLVSELTHHGERAGLAWIRVFVLGFSAAAFFCHLLAFLFSDRDRLHCLFARNILLGMAMTLSFVQFLEFLTFHHLFGPWAIIIRDLIKDLTRFAVILALFHVAFTMQLSAVYQPVYPDDTATQSLNETETVHSESNIQDPIDITVLLFFSLFGLVEPGCLPSLNRTPQFTFVIVRFVFGVYLIVTLIVLINLLIAMMSDTYQRIQAQSDTEWKFGRATLIRDMTRKPGTPSPFNLFTNLFYYIKLLCKHKGKLCSANARNLMSEEDIDGFSDTRSIDLLAQTSLSWIRTPAKRTMQVAPEGKNLHVLRVLLFCIPVNVKGKFST
Protein: Galanin-like G-protein coupled receptor npr-9 (Probable neuropeptide receptor 9) (Q23497)
Organism: Caenorhabditis elegans
Function: Neuropeptide that controls movement such as roaming, foraging and backwards locomotion or 'reversals' in response to environmental cues such as food availability or volatile odorants such as octanol. Antagonizes AIB interneuron activity to control bacterial colonization and may negatively regulate the expression of immunity-related genes such as pqm-1 and dod-22 in response to infection by P.aeruginosa.
Subcellular location: Cell membrane {ECO:0000305|PubMed:18216257}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neuropeptide-Like Protein
- Neuropeptide-Like Protein
Sequence:
MEFENLTKEEMEQLQKIYDDTISFERKIGIIIPTIFAVIILVGLVGNALVVIVAFGRQMRNSTNTLIIGLAISDLMFLLLCVPFTAVDYAAPTWIFPEWTCSMINFFQHTSAYCSVWTLTLMALDRYLAVVYPVESMTLRTPRNTVIALCFIYIIIIASQIPVGRMHGIYVYDFIMEKRSTCAILTIATAEATPTMARTYFMTFNVFGYVLPLGISVVLYGLMLRKLWDMPRPGNSQSVGGRNLTNRDSGSSIRRRPEATAAKRKVTRLVLCVLITWALCWLPLNVCFFMSGLAYPEPLVISHGVIMVIVQIASQVLAYTNSCLNPILYALMSQSFREGFIRVMKMLINKLSRGRFCTNYRRSALRTELTHYNQTPAHPANTVVQVSNGERSSLLKDNSSSATSVQPLRTSIQAKKTKNIGRSKSTRSYNL
Protein: Lectin-related NK cell receptor LY49V (Q9JHV0)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSEQEVTYSTVRFHKSAGLQKQVRPEETKGPREAGYRRCSVPWKFIVIALGILCFLLLVTVSVLAIKIFQYGQQKKLQEILNHHNNCSNMQSDINLKDEQLKNKSIECNLLESLNRDKNRLYNKTKTVLDSLQHTGRGDKVYWFCYGMKCYYFVMDRKPWIRCKQTCQNSSFSLLKIDNEDELKFLQLVVPSDSCWIGLSYDNKKKDWAWIDNHPSKLALNTMKYNIRDGGCMFLSKTRLDNNYCDQSLICICGRRLDKFPH
Protein: Transmembrane and immunoglobulin domain-containing protein 1 (Q6UXZ0)
Organism: Homo sapiens (Human)
Function: May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26342724}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:26342724}.
Interaction partners:
- Guanylin
- Clarin-3
Sequence:
MAWKSSVIMQMGRFLLLVILFLPREMTSSVLTVNGKTENYILDTTPGSQASLICAVQNHTREEELLWYREEGRVDLKSGNKINSSSVCVSSISENDNGISFTCRLGRDQSVSVSVVLNVTFPPLLSGNDFQTVEEGSNVKLVCNVKANPQAQMMWYKNSSLLDLEKSRHQIQQTSESFQLSITKVEKPDNGTYSCIAKSSLKTESLDFHLIVKDKTVGVPIEPIIAACVVIFLTLCFGLIARRKKIMKLCMKDKDPHSETAL
Protein: GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1) (P70426)
Organism: Mus musculus (Mouse)
Function: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation (By similarity).
Subcellular location: Cell membrane.
Interaction partners:
Sequence:
MESGARPIGSSCSSPAALSREYKLVMLGAGGVGKSAMTMQFISHRFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVSKEEGLSLAREFSCPFFETSAAYRYYIDDVFHALVREIRKKEKELVLAMEKKAKPKNSVWKRLKSPFRRKKDSVT
Protein: Cyclomaltodextrinase (CDase) (EC 3.2.1.54) (Cyclomaltodextrin hydrolase, decycling) (A0A7U9P668)
Organism: Geobacillus thermopakistaniensis (strain MAS1)
Function: Hydrolyzes alpha-, beta- and gamma-cyclodextrins with the highest activity with alpha-cyclodextrin (cyclomaltohexaose). Pullulan is the preferred substrate from linear substrates. Maltose is a major product of these reactions. Is also able to hydrolyze maltotriose and acarbose, and transglycosylate their hydrolytic products. Major reaction products of maltotriose and of acarbose are maltose and glucose, and glucose and pseudotrisaccharide, respectively. No activity with glucose or maltose as substrate.
Interaction partners:
Sequence:
MRKEAIHHRSTDNFAYAYDSETLHLRLQTKKNDVDHVELLFGDPYEWHDGAWQFQTMPMRKTGSDGLFDYWLAEVKPPYRRLRYGFVLRAGGEKLVYTEKGFYHEAPSDDTAYYFCFPFLHRVDLFQAPDWVKDTVWYQIFPERFANGNPAISPKGARPWGSEDPTPTSFFGGDLQGIIDHLDYLADLGITGIYLTPIFRAPSNHKYDTADYFEIDPHFGDKETLKTLVKRCHEKGIRVMLDAVFNHCGYEFGPFQDVLKNGAASRYKDWFHIREFPLQTEPRPNYDTFAFVPQMPKLNTAHPEVKRYLLDVATYWIREFDIDGWRLDVANEIDHQFWREFRQAVKALKPDVYILGEIWHDAMPWLRGDQFDAVMNYPLADAALRFFAKEDMSASEFADRLMHVLHSYPKQVNEAAFNLLGSHDTPRLLTVCGGDVRKVKLLFLFQLTFTGSPCIYYGDEIGMTGGNDPECRKCMVWDPEKQNKELYEHVKQLIALRKQYRALRRGDVAFLAADDEVNHLVYAKTDGNETVMIIINRSNEAAEIPMPIDARGKWLVNLLTGERFAAEAETLCVSLPPYGFVLYAVESW
Protein: Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304) (Q9QWJ9)
Organism: Rattus norvegicus (Rat)
Function: Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity).
Subcellular location: Mitochondrion membrane {ECO:0000250|UniProtKB:O14786}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O14786}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O14786}.
Interaction partners:
- Plexin-A4
- Plexin-A2
- Plexin-A3
- Plexin-A1
- Semaphorin-3A
- Vascular endothelial growth factor receptor 2
- Semaphorin-3B
- Semaphorin 3D
- Semaphorin-3C
- Neural cell adhesion molecule L1
Sequence:
MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVFGVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYPERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLHYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIPQEDCAKPTDLDKKNTEIKIDETGSTPGYEEGKGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA
Protein: Vesicle transport protein USE1 (Protein D12) (USE1-like protein) (Q9CQ56)
Organism: Mus musculus (Mouse)
Function: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
- Syntaxin-18
- Vesicle transport protein SEC20
- Vesicle-trafficking protein SEC22b
- RAD50-interacting protein 1
- Centromere/kinetochore protein zw10 homolog
- Synaptobrevin homolog YKT6
- Syntaxin-5
- Neuroblastoma amplified sequence
- Golgi SNAP receptor complex member 2
- BET1 homolog
Sequence:
MAQAEGAYHRPLATSRLELNLVRLLCRCESMAAEKREPDEWRLEKYVGALEDMLQALKVQASKPASEVISEYSRKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTAKERVPATKTVHLQSRARYTSEMRSELLGMEPSGECEVDMRKRAAKGSRPADERQSASELDLVLQRHQGLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKLESERLEQHAQKSVNWLLWAMLIVVCFVFISMILFIRIMPRLK
Protein: Homeobox B8 (I3L383)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
XYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKQKLERAPEAADEGDAQKGDKKNGSVQGPWAGSCALGAPRKTCSISARISGAPRETES
Protein: Zinc finger protein Noc (Zinc finger protein NocA) (Q24423)
Organism: Drosophila melanogaster (Fruit fly)
Function: May negatively regulate Notch-induced cell proliferation in the eye-head primordium. Required for development of the supraesophageal ganglion and ocelli. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Plays a role in tracheal development.
Interaction partners:
- Elastin-like, isoform A
Sequence:
MVVLEGGGGVVTIGNNQYLQPDYLAPLPTTMDAKKSPLALLAQTCSQIGADSSAVKPLLAMDKNKTKPGACSSSSNSSSSSGSAEISAAKSPSGQAKSPKSSTPISSTATSASLSNTSTGEIKLAFKPYETNVLSHQNQNSFKSSSSLDAEPTRPSSKNSSSAQERVPSRSKSNATPTDGGKAEISAHDSSSSRKTVSPSGSSQRGASPIVRSGMEVLNNANGTAQHPKEMSSMAAAAAAAAAAYKAAGPYGLNPLSALCCPPGMEQHANPAFRPPFAGGFSHHHAAMLAVAANGGYPGGAPGGGPAGQPNPYISYQRIKTPAGGEAIVPVCKDPYCQGCPYSAHTQQMLMGAPCPAGCTQCEHQKYGLAMASAAGLPPAHPYSQAAAAAAANAAAARSAPYVCSWVVGDAYCGKRFQTSDELFSHLRTHTGNLSDPAAAAAALAQSQAQSLLGTLFPPSALRAGYPTPPLSPMSAAAAAARYHPYAKPPPGALAGGPSPFGAAGAFNPAAAAAAAALGPYYSPYAMYGQRMGAAHQ
Protein: Dapper homolog 1 (Frodo 1) (Q6QZN6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 and may regulate the degradation of ctnnb1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Seems to activate the canonical Wnt signaling pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15539487}.
Interaction partners:
- Dishevelled segment polarity protein 2.
- Vang-like protein 2
- Protein naked cuticle homolog 1
- Vang-like protein
Sequence:
MNEWSEMLVCRDYCALMMRDRKECDARCCRDGEGERVRARERLDATVAGLTELEYLRQRQELLVRSVLSCPEAAGQDKPCLTVDDSYLNTEEKLLEENILLLRKQLNCLRRRDAGLINQLQELDRQISDLRLDTETSHEHVETDSRPSSGFYDLSDGASGSLSNSSNSVFSECLSSCRSTTCLCTPLDTSLCASEGRLKPADDPGSCAECDCHCEDSSSGTVRRSLSASYSPSPDSSCDGISKFHCDLIAKNGNDVYRYPSPLHAVAVQSPIFIQSMTSHLKDDCNFSKPGEALNDEQKPEQVVGSQTSSWHASQMLPNKKLDSYIYGLLQRRAQPLRTNKPRTSINTDPSKSILRQASLCSRAPASVQAQQWTSDLKPNWQTCLQDASATSTEPSTASPQRQWSAESKGGTPQNGAYLSSSQPQNSYSTTNENTNCLLKKKVSGTSKGQLLSATPKDCPDLGSPKAVSSPKLNKHCFYNVEDNKTGQAMKASPLKRSPKTQTSLSCGKDSEQLAQELVSLGSSSQSQDEGGPLVSAQYIPAQKQNVNLQKGGTKNIKIVKVKNSASSKSRPQVFEHVSETVRDKHRTGSRRTRQVDEVHHLHKSSKKASAKTKRIPASIPEGRILERHTSSSGARSSAQRHHGHHRHHEAVLAKPKYKRNDFHRRPRGLHEIPYEEAYRRAHRRQKREMLSHMYLPSNAHYTSPYAYVGSDSEYSAECASLFHSTILDTSEDERSNYTTNCFGDSESSASEADYVAESSTSSDSEGSAGVNWRQISQAGSGSHGMTSAQAKAFVKIKASHNLKKKILRFRSGSLKLMTTV
Protein: F-box only protein 25 (Q9D2Y6)
Organism: Mus musculus (Mouse)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT).
Subcellular location: Nucleus {ECO:0000269|PubMed:16714087, ECO:0000269|PubMed:18287534}. Note=In the nucleus, associates with a specific and novel subnuclear dot-like structure. Colocalized with SKP1.
Interaction partners:
- S-phase kinase-associated protein 1
- F-box only protein 32
- Cullin-1
Sequence:
MPFLGQDWRSPGWSWIKTEDGWKRCDPCSHELRSEDSQYTINHSIILNSGEEEIFNNECEYAAKKRKKEHFGNDTAAHSFYREKWIYVHKESTKERHGYCTLGEAFNRLDFSSAIQDIRRFTYVVKLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLDDHQNPRLIKGLLQDLSSTLGILVRGVGKSVLVGNINIWICRLETVLSWQQQLQNLQVTKQVNTGLTLSDLPLHMLNNILYRFSDGWDIVTLGQVTPTLYMLSEDRRLWKRLCQYHFAEQQFCRHLILSEKGHIEWKLMYFTLQKYYPTKEQYGDTLHFCRHCSILFWKDSGHPCTAADPDSCFTPVSPEHFIDLFKF