wanglab/gogpt-training-data huggingface dataset:
Protein: Myocardial zonula adherens protein (Q3UIJ9)
Organism: Mus musculus (Mouse)
Function: Plays a role in cellular signaling via Rho-related GTP-binding proteins and activation of transcription factor SRF. Targets TJP1 to cell junctions (By similarity). In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20093627}. Cell membrane {ECO:0000269|PubMed:20093627}; Peripheral membrane protein {ECO:0000269|PubMed:20093627}; Cytoplasmic side {ECO:0000269|PubMed:20093627}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000269|PubMed:20093627}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:20093627}. Cell junction {ECO:0000250|UniProtKB:P0CAP1}. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin.
Interaction partners:
- DNA-directed RNA polymerase II subunit GRINL1A
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MLRSTSTVTLFSGGGAKSPGTPSRRANVCRLRLTVPPENPVPQQTEKKIERKDQPPELSNGESTKRLPQGVVYGVVRRSDPNQQKEMVVYGWSTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQDLSVSHAQQDYLDSHIQAQASALDSFNAMNAALASDSVGLQKTLVDVTLENSHIKDQIRHLQQTYEASMDKLREKQRQLEAAQMENQLLKMRVESSQEANAEVMREMTRKLYSQYEEKLQEAQRKHSAEKEVLLEETNSFLKAIEEANKKMEAAELSLEEKDQKIGELDRLIERMEKERHQLQLQLLEHETEMSGEMADSDKNRYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQPKTEVETREIGVGCDLLPSPTGRTREITMPSRSYTPYTRVLELSSKKTLT
Protein: Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) (P81125)
Organism: Bos taurus (Bovine)
Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Together with GNA12 promotes CDH5 localization to plasma membrane (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P54920}; Peripheral membrane protein {ECO:0000250|UniProtKB:P54920}.
Interaction partners:
- Synaptosomal-associated protein 25
- Vesicle-associated membrane protein 2
- Syntaxin-1A
- Syntaxin-1B
- Vesicle-fusing ATPase
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Syntaxin-5
- Sec1 family domain-containing protein 1
- Syntaxin-16
- Vesicle-associated membrane protein 8
Sequence:
MDNSGKEAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGSAFCQAAHVHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAAQLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKRIKKLLEAHEEQNVDSYTEAVKEYDSISRLDQWLTTMLLRIKKTIQGDEEDLR
Protein: S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1) (P63208)
Organism: Homo sapiens (Human)
Function: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.
Interaction partners:
- F-box only protein 22
- Cullin-7
- Cyclin-dependent kinase 2
- F-box/LRR-repeat protein 15
- F-box/WD repeat-containing protein 8
- S-phase kinase-associated protein 2
- Catenin beta-1
- F-box/WD repeat-containing protein 11
- F-box/WD repeat-containing protein 1A
- NF-kappa-B inhibitor alpha
Sequence:
MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK
Protein: TNF receptor associated factor 7 (A0A8I6A9T1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSQSRTGRLRARDNPKGSVALPDVSIPSAPSSTDSCVTQPFPSLSAADGTSTYKQHRRTPSSSSTLAYSPRDEEDGMPPINTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNAKLTVVVNNIAVAEQIGELFIHCRHGCRAAGTGKPGVFEVDPRGCPFTIKLSARKDHESSCDYRPVRCPNNPSCPPLLKMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNMLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC
Protein: Perilipin-5 (Lipid droplet-associated protein PAT-1) (Lipid storage droplet protein 5) (Myocardial LD protein) (Q8BVZ1)
Organism: Mus musculus (Mouse)
Function: Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
Subcellular location: Lipid droplet {ECO:0000269|PubMed:16571721, ECO:0000269|PubMed:17130488, ECO:0000269|PubMed:17234449, ECO:0000269|PubMed:19717842, ECO:0000269|PubMed:23345411}. Cytoplasm {ECO:0000269|PubMed:17234449, ECO:0000269|PubMed:19717842}. Mitochondrion {ECO:0000250|UniProtKB:M0R7Z9}. Note=Lipid droplet surface-associated (PubMed:16571721, PubMed:17130488, PubMed:17234449). Exchanges between lipid droplets and the cytoplasm (PubMed:19717842). {ECO:0000269|PubMed:16571721, ECO:0000269|PubMed:17130488, ECO:0000269|PubMed:17234449, ECO:0000269|PubMed:19717842}.
Interaction partners:
- Patatin-like phospholipase domain-containing protein 2
- 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
- Hormone-sensitive lipase
- Peroxisome proliferator-activated receptor alpha
- Lipid transferase CIDEC
Sequence:
MDQRGEDTTLAPHSRMSGDQTAQDPGSSLGELDQQNVVNRVVALPLVKATCTAVSSAYNSAKDRHPLLGSACRLAEHCVCSVTTCALDHAQPLLEHLQPQLATVNDLACRGLDKLEEKLPFLQQPSDMVVTSAKDTVAKSVTGMVDLAQRGRRWSGELRRSMSQAMDMVLGKSEKLVDRFLPMTEAELAVLAAEAEGPEVGTVEEQRQQQGYFVRLGSLSARLRHLAYEHSLGKLRQSKHRTQEMLAQLQETLELIQHMQRGASPSPTFHPPKTQELWGSWSPCLENGRSHSEVELETLALSRSLTLELQNAVDALAGCVRGLPPSAQAKVAEVQRSVDALQATFADAHCLGDVAPTALAEGRGSVARAHACVDEFLDLVLRAMPLPWLVGPFAPILVEQSEPLINLATCVDEVVGDPDPRWAHMDWPAQKRAWEAESADPGGQEAEPPRGQGKHTMMPELDF
Protein: Terminal nucleotidyltransferase 5C (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46C) (Q5VWP2)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.
Subcellular location: Nucleus {ECO:0000269|PubMed:28931820}. Cytoplasm {ECO:0000269|PubMed:28931820}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:32433990}. Note=Recruited into the centrosome through its interaction with PLK4. {ECO:0000269|PubMed:32433990}.
Interaction partners:
- Serine/threonine-protein kinase PLK4
- Centrosomal protein of 192 kDa
- Exosome complex exonuclease RRP44
Sequence:
MAEESSCTRDCMSFSVLNWDQVSRLHEVLTEVVPIHGRGNFPTLEITLKDIVQTVRSRLEEAGIKVHDVRLNGSAAGHVLVKDNGLGCKDLDLIFHVALPTEAEFQLVRDVVLCSLLNFLPEGVNKLKISPVTLKEAYVQKLVKVCTDTDRWSLISLSNKNGKNVELKFVDSIRRQFEFSVDSFQIILDSLLFFYDCSNNPISEHFHPTVIGESMYGDFEEAFDHLQNRLIATKNPEEIRGGGLLKYSNLLVRDFRPTDQEEIKTLERYMCSRFFIDFPDILEQQRKLETYLQNHFAEEERSKYDYLMILRRVVNESTVCLMGHERRQTLNLISLLALRVLAEQNIIPSATNVTCYYQPAPYVSDGNFSNYYVAHPPVTYSQPYPTWLPCN
Protein: 3-alpha-hydroxysteroid dehydrogenase type 1 (Aldo-keto reductase family 1, member C14) (Q91WT7)
Organism: Mus musculus (Mouse)
Interaction partners:
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Sequence:
MNSVSPRVVLNDGHFIPALGFGTTVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQLETILNKPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKIWVDQKSPVLLDDPVLCAMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYNTASYFDDHPNHPFTDEY
Protein: SLIT and NTRK-like protein 3 (Q810B9)
Organism: Mus musculus (Mouse)
Function: Suppresses neurite outgrowth.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase delta
- Receptor-type tyrosine-protein phosphatase S
- Neuroligin-2
- Neuroligin-1
- Interleukin-1 receptor accessory protein-like 1
Sequence:
MMKPSIAEMLHRGRMLWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRRLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPVLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIKKTELCPLLSDSEVEASLGIPHLSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRTPENLTHRDVRTIELEVLCPEMLHIAQPGPSPPQPGDYHPNGGPTSASPYEFSPPGGPVPLSVLILSLLVLFFSAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCHRLFEDSGGNSGGSGGGGRPTLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAASAAQDTGATDRGGPGTQPTGMAEVLLGSEQFAETPKENHSNYRTLLEKEKEWALAVSNSQLNTIVTVNHHHPHPHHSAVGGVSGVGGGTGGDLAGFRHHEKNGGVVLFPPGGGCGGGSLLLDRERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQYPDLQQDARLKETLLFSAGKGFTDHQTPKSDYLDLRAKLQTKPDYLEVLEKTAYRF
Protein: Ubiquitin-conjugating enzyme variant MMS2 (UEV MMS2) (P53152)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has a role in the DNA error-free postreplication repair (PRR) pathway. Lacks catalytic activity by itself. The UBC13/MMS2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.
Interaction partners:
- DNA repair protein RAD5
- Ubiquitin-conjugating enzyme E2 13
- Polyubiquitin
- DNA polymerase zeta catalytic subunit
- Ubiquitin-conjugating enzyme E2 2
- Postreplication repair E3 ubiquitin-protein ligase RAD18
- Protein SIP5
- DNA polymerase eta
- Ubiquitin-ribosomal protein eS31 fusion protein
- DNA repair protein REV1
Sequence:
MSKVPRNFRLLEELEKGEKGFGPESCSYGLADSDDITMTKWNGTILGPPHSNHENRIYSLSIDCGPNYPDSPPKVTFISKINLPCVNPTTGEVQTDFHTLRDWKRAYTMETLLLDLRKEMATPANKKLRQPKEGETF
Protein: Thymocyte selection-associated high mobility group box protein TOX (Thymus high mobility group box protein TOX) (O94900)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (By similarity). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
Sequence:
MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTSQPPQLINSKPSVFHGPSQAHSALYLSSHYHQQPGMNPHLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLNMQQHQPLTMQQPLGNQLPMQVQSALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWNNDYCSSGGMQRDKALYLT
Protein: E3 ubiquitin-protein ligase GW2 (EC 2.3.2.27) (Protein GRAIN WIDTH AND WEIGHT 2) (RING-type E3 ubiquitin transferase GW2) (B9F4Q9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: E3 ubiquitin-protein ligase involved in the regulation of grain size. May limit grain width and weight by restricting cell proliferation of the spikelet hull. Possesses E3 ubiquitin-protein ligase activity in vitro.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17417637}.
Interaction partners:
- Os05g0509900 protein
- Os01g0772200 protein
- Os06g0254600 protein
- Os02g0734600 protein
- Os06g0254700 protein
- Os03g0712300 protein
- Os12g0605400 protein
- Os04g0684800 protein
- Os02g0734400 protein
- Os09g0297100 protein
Sequence:
MGNRIGGRRKAGVEERYTRPQGLYEHRDIDQKKLRKLILEAKLAPCYMGADDAAAAADLEECPICFLYYPSLNRSKCCSKGICTECFLQMKPTHTAQPTQCPFCKTPSYAVEYRGVKTKEERSIEQFEEQKVIEAQMRMRQQALQDEEDKMKRKQNRCSSSRTITPTKEVEYRDICSTSFSVPSYRCAEQETECCSSEPSCSAQTSMRPFHSRHNRDDNIDMNIEDMMVMEAIWRSIQEQGSIGNPVCGNFMPVTEPSPRERQPFVPAASLEIPHGGGFSCAVAAMAEHQPPSMDFSYMAGSSAFPVFDMFRRPCNIAGGSMCNLESSPESWSGIAPSCSREVVREEGECSADHWSEGAEAGTSYAGSDIVADAGTMPQLPFAENFAMAPSHFRPESIEEQMMFSMALSLADGHGRTHSQGLAWL
Protein: Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) (Q6NXS1)
Organism: Homo sapiens (Human)
Function: Inhibitor of protein-phosphatase 1.
Interaction partners:
Sequence:
MAASTASHRPIKGILKNKTSTTSSMVASAEQPRRSVDEELSKKSQKWDEINILATYHPADKGYGLMKIDEPSPPYHSMMGDDEDACRDTETTEAMAPDILAKKLAAAEGLEPKYRIQEQESSGEEDSDLSPEEREKKRQFEMRRKLHYNEGLNIKLARQLISKDLHDDDEDEEMLETADGESMNTEESNQGSTPSDQQQNKLRSS
Protein: Gamma-glutamyl transpeptidase, isoform A (EC 3.4.19.13) (Gamma-glutamyl transpeptidase, isoform B) (LD42301p) (Q9VWT3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glutathione peroxidase
- Glutathione peroxidase
- RE13973p
- FI03324p
- Dipeptidase B, isoform A
- Glutamate--cysteine ligase
- Glutathione S transferase O3
- 1-Cys peroxiredoxin
- Pyrimidodiazepine synthase
- Cytosol aminopeptidase
Sequence:
MRIVWSKKLLLWLLLAALMVTALTLGLVFGLKNRDTLYISGAVVSNGIGCAAVGGEMLTDGGSAVDAAIATLLCEGLLLPHSMGIGGGFVATIYTRSSRKVETVIARESAPAAAHKDMFVGETSITGAKSGAVPGEILGYWEMHRRYGILPWKRLFEPSIKLAREGHVVSRYLAAAIQSKLDNIKADPGLSAVFLNATGDPHLEGDYMKRPALADTLERIAENGAKEFYDGGETGRKFVEDIQKMGGIITEQDLRDYTVRWESDGHVSAHVSGTYTLYSTPMPSSGPVLAFILNLMADLYTDNEPIYWQRVVEAFKHAYGQRTNLGDMYADPVSAASINATLEEMLKPEFLESVRKLIHDNSTSEDYLYYGANFTVEEDHGTAHMNVLATNGDAVSITSTINNYFGSKVASTQTGIILNDEMDDFSTPGVINGFGVPASPANYIYPGKRPMSSMSPCIIVDQEGNVRLLVGAAGGTRITTSVAAVIMKYLLRKESLTAAVNNGRLHHQLAPMRVSYEQEVDSSVTDYLKQVGHEMYEEPVGSSFAAVTAIGALEQPEPFYDRRRIGSALTLAKTNKMQH
Protein: PAT complex subunit CCDC47 (Calumin) (Coiled-coil domain-containing protein 47) (Q96A33)
Organism: Homo sapiens (Human)
Function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity). Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway. Has an essential role in the maintenance of ER organization during embryogenesis (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25009997, ECO:0000269|PubMed:30401460, ECO:0000269|PubMed:32814900}; Single-pass type I membrane protein {ECO:0000255}. Rough endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D024}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Calcium load-activated calcium channel
- Protein transport protein Sec61 subunit alpha isoform 1
- BOS complex subunit NCLN
- BOS complex subunit TMEM147
- PAT complex subunit Asterix
- Large ribosomal subunit protein eL38
- Protein transport protein Sec61 subunit beta
- Protein transport protein Sec61 subunit gamma
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL18
Sequence:
MKAFHTFCVVLLVFGSVSEAKFDDFEDEEDIVEYDDNDFAEFEDVMEDSVTESPQRVIITEDDEDETTVELEGQDENQEGDFEDADTQEGDTESEPYDDEEFEGYEDKPDTSSSKNKDPITIVDVPAHLQNSWESYYLEILMVTGLLAYIMNYIIGKNKNSRLAQAWFNTHRELLESNFTLVGDDGTNKEATSTGKLNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMRPVSDQVQIKVTMNDEDMDTYVFAVGTRKALVRLQKEMQDLSEFCSDKPKSGAKYGLPDSLAILSEMGEVTDGMMDTKMVHFLTHYADKIESVHFSDQFSGPKIMQEEGQPLKLPDTKRTLLFTFNVPGSGNTYPKDMEALLPLMNMVIYSIDKAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRREEKKRAEKERIMNEEDPEKQRRLEEAALRREQKKLEKKQMKMKQIKVKAM
Protein: Photosystem II extrinsic protein O (PsbO) (Photosystem II manganese-stabilizing polypeptide) (MSP) (P10549)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: MSP binds to a putative Mn-binding protein and keeps 2 of the 4 Mn-atoms associated with PSII.
Subcellular location: Cellular thylakoid membrane {ECO:0000269|PubMed:12069591, ECO:0000269|PubMed:34937700}; Peripheral membrane protein {ECO:0000269|PubMed:34937700}; Lumenal side. Note=CyanoQ (PsbQ) binds to the large lumenal domain of PsbC (CP43) between PsbO and PsbV. {ECO:0000269|PubMed:34937700}.
Interaction partners:
- Cytochrome b559 subunit alpha
- Photosystem II reaction center protein L
- Photosystem II extrinsic protein U
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein K
- Photosystem II D2 protein
- Cytochrome b559 subunit beta
- Photosystem II reaction center protein I
- Photosystem II extrinsic protein V
- Photosystem II reaction center protein H
Sequence:
MRFRPSIVALLSVCFGLLTFLYSGSAFAVDKSQLTYDDIVNTGLANVCPEISSFTRGTIEVEPNTKYFVSDFCMEPQEYFVKEEPVNKRQKAEYVKGKVLTRQTTSLEQIRGSIAVGADGTLTFKEKDGIDFQPITVLLPGGEEVPFFFTVKNFTGTTEPGFTSINSSTDFVGDFNVPSYRGAGFLDPKARGLYTGYDNAVALPSAADKFRTNKKETPLGKGTLSLQVTQVDGSTGEIAGIFESEQPSDTDLGAKEPLDVKVRGIFYGRVDTDV
Protein: Opsin Rh4 (Inner R7 photoreceptor cells opsin) (P08255)
Organism: Drosophila melanogaster (Fruit fly)
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Opsin Rh1
- Phosrestin-1
- Opsin Rh3
- Guanine nucleotide-binding protein subunit beta-2
- Transient-receptor-potential-like protein
- Protein kinase C, eye isozyme
- MORN repeat-containing protein 4 homolog
- Phosrestin-2
- Homeotic protein ocelliless
Sequence:
MEPLCNASEPPLRPEARSSGNGDLQFLGWNVPPDQIQYIPEHWLTQLEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLKAPIFIYNSFHRGFALGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNRNMTFTKAVIMNIIIWLYCTPWVVLPLTQFWDRFVPEGYLTSCSFDYLSDNFDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKALREQAKKMNVESLRSNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGAFGDKSLLTPGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWLGVNEKSGEISSAQSTTTQEQQQTTAA
Protein: Stromal cell-derived factor 1 (C-X-C motif chemokine 12) (Q80YV8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Atypical chemokine receptor 3
- C-X-C chemokine receptor type 4
- C-C motif chemokine receptor 7
- C-X-C chemokine receptor type 5
- C-X-C motif chemokine
- C-X-C chemokine receptor type 3
- C-C chemokine receptor type 5
- C-X-C chemokine receptor type 2
- C-C motif chemokine 5
- C-X-C motif chemokine 10
Sequence:
MDAKVVAVLALVLAALCISDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKSNNRQVCIDPKLKWIQEYLDKALNKGRREEKVGKKEKIGKKKRQKKRKAAQKKKN
Protein: Synaptotagmin 7 (Synaptotagmin VIIb) (Synaptotagmin-7b) (D4P8S0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Synapsin-1
- Frequenin homolog b
- Synapsin-1
- Synaptosomal-associated protein 25-A
- Vesicle-associated membrane protein 4.
Sequence:
MHLNREDEDGKGSLSLSVFLVSVGLTVCVVWLVALCGVCGWCQRKLGMRNKPGVETAGTPDSVSVSGRGRGENKAINHNDLDRDFWNNNDSCSVQQRWSSYPPKEFLLNMSPYAPYGDPRLTPKEGKMVVLSLAIGLAEQDDFANLPDLQEAPADTETPPTDKRSNKPGSSPKGQTPDESHRRTDANSSVSDLANSVTSDMLMLSPGSEEEEHEGPVCEKLGRIQFSVGYSFQDSTLTVKILKGQDLPAKDFSGTSDPFVKLYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRTLYLQVLDYDRFSRNDPIGEVSIPLNKVELVPMQTLWKELKPCSDGSGSRGDLLVSLCYNPTANIITVSIIKARNLKAMDIGGTSDPYVKVWLMNKDKRVEKKKTVVMKRCLNPVFNESFPFDVPAHVLRETTIVITVMDKDRLSRNDVIGKIYLSWKSGPAEVKHWKDMMSHPRTAVAQWHALKA