wanglab/gogpt-training-data huggingface dataset:
Protein: Mycothiol acetyltransferase (MSH acetyltransferase) (EC 2.3.1.189) (Mycothiol synthase) (P9WJM7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
Interaction partners:
- L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
- 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
- D-inositol 3-phosphate glycosyltransferase
- Mycothiol S-conjugate amidase
- Transcriptional regulatory protein
- Polyphosphate kinase
- Phosphate import ATP-binding protein PstB 1
- Probable thioredoxin ThiX
- Thioredoxin-like reductase Rv2466c
- Uncharacterized protein Rv1998c
Sequence:
MTALDWRSALTADEQRSVRALVTATTAVDGVAPVGEQVLRELGQQRTEHLLVAGSRPGGPIIGYLNLSPPRGAGGAMAELVVHPQSRRRGIGTAMARAALAKTAGRNQFWAHGTLDPARATASALGLVGVRELIQMRRPLRDIPEPTIPDGVVIRTYAGTSDDAELLRVNNAAFAGHPEQGGWTAVQLAERRGEAWFDPDGLILAFGDSPRERPGRLLGFHWTKVHPDHPGLGEVYVLGVDPAAQRRGLGQMLTSIGIVSLARRLGGRKTLDPAVEPAVLLYVESDNVAAVRTYQSLGFTTYSVDTAYALAGTDN
Protein: Ankyrin repeat and MYND domain-containing protein 2 (Q3TPE9)
Organism: Mus musculus (Mouse)
Function: May be involved in the trafficking of signaling proteins to the cilia.
Subcellular location: Cell projection, cilium {ECO:0000250}.
Interaction partners:
Sequence:
MGHIKKGELTQEEKELLEVIGKGTVQEAGRLLSSKNVHVNCLDENGMTPLMHAAYKGKLEMCKLLLRHGADASCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVAIINNFFPRERLDYYTKPQGLDKEPKLPPKLAGPLHKIITTTNLHPVKIVMLVSENPLLADAAALGKCYRVMDLICEKCMKQRDMNEVLAMKMHYISCIFQKCITFLKEGENKLDTLIRSLLKGRASDGFPVYQEKIIRESIRKFPYCEATLLQQLVRSIAPVEIGSDPTAFSVLTQAITGQVGFVDVEFCTTCGEKGASKRCSVCKMVIYCDQTCQKTHWFAHKKMCKSLKDVYEKQQIEAAKHKRQEEKNGNPNVSSNHVNEDQPEAEEGITQENSIPSDSVEGEKEAANDTGLASAQDAPTGPQLSEE
Protein: Progestin and adipoQ receptor family member 3 (Progestin and adipoQ receptor family member III) (Raf kinase trapping to Golgi) (RKTG) (Q6TCG8)
Organism: Mus musculus (Mouse)
Function: Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:17724343, ECO:0000269|PubMed:26311497}; Multi-pass membrane protein {ECO:0000269|PubMed:17724343}.
Interaction partners:
Sequence:
MHQKLLKSAHYIELGSYQYWPVLVPRGIRLYTYEQIPVSLKDNPYITDGYRAYLPSRLCIKSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLPSASASREDFVICSICLFCFQVCMLCSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGVFYAFYCNNYWRQVYLITVLAMILAVFFAQIHPSYLTQQWQRLRPIIFCSVSGYGVIPTLHWVWLNGGVSAPIVQDFAPRVIVMYVIALLAFLFYISKVPERYFPGQLNYLGSSHQIWHVLAVVMLYWWHQSTVYVMQYRHSKPCPDYVSHL
Protein: Jonah 25Bii, isoform A (Jonah 25Bii, isoform B (EC 3.4.21.-)) (Q9VMX8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Jonah 44E, isoform A
- Jonah 25Bi
- Jonah 99Fii
- Peptidase S1 domain-containing protein
- Jonah 25Biii
- Venom allergen-1
- trypsin
- Serine protease 3
- Trypsin beta
- Trypsin epsilon
Sequence:
MKLFLTVLAVAIACAAAQPEKVKPVPLKDAVLGSGSGSIEGRITNGYPAYEGKVPYIVGLGFSSDSGGWWCGGSIIGHTWVITAAHCTHGAHSVTIYYGALWRLQAQYTHTVGSGHFRQHSDYNTNNLNNDISLINTPHVDFWHLINKVELPDGNERHDSFAGWWALASGWGRPCDSCGVSDYLNCVDSQIITRDECSSVYGTDVITDNVICTSTPGGKSTCAGDSGGPLVLHDRSKLVGVTSFVAASGCTSGLPDGFTRVTSYLDWIRDHTGISY
Protein: FIGalpha (Factor in the germline alpha) (Figla protein) (Q568W8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSCEMTGKKFRAIVGLMKVPERELMGDVLLRESAEPSLPVHVNIGKFVRLDDGQYIDTEDRDKAVKRRQLANAKERLRVRSLNSMFSYLRRIVPVMPRDRKPSKVDMLKAATEYIRLLSAVLNHTSDKGNENANVFLETGINYPSINPDCSDLWNMEDALDSMSSPFLSETVSLTAPLVTMTSGADEDLDLNNMTVQCVVPMYIVQVGSDQTMVPSSLPS
Protein: Androgen receptor alpha (O93244)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MEIPVGLGGVCDSTNLVFRGPFQNVFHNVQALPSNTTVTESLDFCSSKFSFLQNKQPWEMRQASRQSSRKEIWSGTARNSDIEVREDDSVGFSRTLESVACRIHFAKSSKGNKAGFSSLNESDNPNANEYGSCRSGQQVSNTEQQSCQPSVSHHGNELNHNSEACVASSCSSSACSTISKTARELCNAVSVSLGLTMDANEMTDLGPNHAPSSVNHQSQGNYLFEVPLLKCSGAGENVSITEYTCPSERNAKPLQSDKQLVEMFQRSPANDLTEKVATIQHLSSGHPCTDKQEFRLNENRDDPTSKETDHFLNTGARSRSYHFDQLLPAHLAHFSQTETDRNSSHVFYKPPAHVGETGETMEDKYADYLQQQYSVKIKYEAFNRHNELPEPSWDFQYRYNDNDNTQYGLNSYIAGPDSALICNPHEYERGGGLVRRERPTPEQWYPGEMLGRMPYPNSPCIKNEVGDSLDVSYTDARFEGGSDHMYPMEFFFPPQRTCLICAEEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKLRRKNCPSCRLRRCFEAGMTLGTRKLKKIVQLKSPEEDLPTQGPTDTIQGVSPQSGLSFHSQLVFLNILESIEPEVVHAGHDQCQPDSAAALLTSLNELGERQLVKVVKWAKGLPGFRNLHVDDQMTVIQHSWMGVMVFGLGWRSYKNANCRLLYFAPDLVFNDHRMHISSMFDHCIRMRQLSQEFVLLQVTQEEFLCMKALLLFSIIPVDGLKSQKYFDELRLTYINELGRVINYGRKSNCSQRLYQLTRLMDSLQPVVRKLQQFTFDLFVQAQSLPTKVNFPEMIAEIISVHLPKILAGLAKPILFHK
Protein: Calreticulin family protein (F4K6M8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
Sequence:
MRERIITFVSLLLVALLSFPSVSYCDDQTVIGHFLEKILYESFDEPFDGRWVVSEKAEYQGVWKHEKSEGHDDYGLLVSEKAKKYGIVKELDVDEPLNLNEGTVVLQYEARFQEGLECGGAYLKYLRPQEAGWVPQGFDNDSPYSIMFGPDKCGATNKVHFILKHKNPKSGEFVEHHLKFPPSVPFDMLSHVYTAVLKSDNEVRILVDGEEKKKGNLLSAEDFEPPLIPSKTIPDPEDKKPEDWDERAKIPDPNAVKPDDWDEDAPMEIEDEEAEKPEGWLDDEPVEVEDPEASKPEDWDDEEDGEWEAPKVSNTKCEAAPGCGEWKRPMKRNPAYKGKWSSPLIDNPAYKGIWKPRDIPNPDYFELERPNLEPIAAIGIEIWTMQDGILFDNILISKDEKVAETYRQSTWKPKFDVEKEKQKAEDEAAGEADGLKSYQKKVFDLLYKVADISFLSAYKSKIMELIEKAETQPNLTIGVLISIVIVFLSLFFKLIFGGAKAKVEKKKPETAAETSTSEAKTEEKAEAVAAPRKRQTRRES
Protein: Hgt12p (A0A1D8PQJ5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Carbon catabolite-derepressing protein kinase
- Ngt1p
- Hgt2p
- Hxt5p
Sequence:
MSANIQALMKSYVNFDEHTSGSAARGILIGMFAAFGGFLFGYDTGTISGVLSMDYVKARFPNNKTDFTSGESSLIVSILSVGTFVGSLIAPLFSDRIGRRWTLILSTLIVFNLGVLLQTVATEKKLLIAGRAIAGTGVGLISSVIPNYISETTPKWARGAVTASYQWMITWGLLIAACANKGSQGRKDSGSYRIPIGIQFLWALILGIGFLFLPETPRYWVSKSEETKAKDSLRRIRNLPVDHPDLVSEYDDIKANFDFESKYATSSWTQVFKNVNKQHHRLFTGVAIQALQQLTGINFIFYYGTQFFKRSGIEDPFLIQLATNIVNVGMTVPGIILVETWGRRPLLMAGSVVMAVSQLIVAIVGVAASSHAANQCLVAFSCIFIAGFAATWGPLCWAICGESFALNVRSKSISLCTASNWLWNFGIGYATPYMVDSGKGNADLGSKVFFIWGGCNVIGGLFAYFMVYETKSLTLEQVDELYLKVDHAWQSKGFVPSVHAFRDDGDIEHISSDGKAEMVEVDENSV
Protein: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform BRA) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) (P36876)
Organism: Rattus norvegicus (Rat)
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.
Interaction partners:
- Protein phosphatase 2 scaffold subunit A alpha
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
- Protein phosphatase 2, regulatory subunit B'', alpha
- Interleukin-1 receptor-associated kinase 1
- Apoptosis regulator Bcl-2
- WW domain containing transcription regulator 1
Sequence:
MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN
Protein: Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8) (Q6IA17)
Organism: Homo sapiens (Human)
Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Subcellular location: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Interaction partners:
- Interleukin-1 receptor-associated kinase 1
- Interleukin-37
- Myeloid differentiation primary response protein MyD88
- Toll-like receptor 4
- Interleukin-18 receptor 1
- TNF receptor-associated factor 6
- Interleukin-1 receptor-associated kinase 3
- Toll-like receptor 5
- Interleukin-33
- Toll/interleukin-1 receptor domain-containing adapter protein
Sequence:
MPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDKDPMLILRGRVPEGRALDSEVDPDPEGDLGVRGPVFGEPSAPPHTSGVSLGESRSSEVDVSDLGSRNYSARTDFYCLVSKDDM
Protein: Betainyl-CoA thioesterase (EC 3.1.2.33) (Betainyl-CoA thiolase) (Q9HTH9)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- L-carnitine dehydrogenase
- 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase
- Probable lipolytic enzyme
- ABC-type glycine betaine transport system substrate-binding domain-containing protein
- HTH-type transcriptional regulator CdhR
Sequence:
MSQVLTTYETPVLPEWVDYNGHLRDAFYLLVFSYATDALMAHIGLDSQNRDASGHSLFTLECHLNFLHEVKEGARVEVRTQLLGHDRKRLHIHHALYLPGSGQALALSEQMLLHVSLDGPRSAPFEGEVLARVEALAEAHRALPVPEGVGRVIGLPPVR
Protein: 23S rRNA (uracil(747)-C(5))-methyltransferase (EC 2.1.1.189) (23S rRNA(m5U747)-methyltransferase) (Q9UZK1)
Organism: Pyrococcus abyssi (strain GE5 / Orsay)
Function: Catalyzes the formation of 5-methyl-uridine at position equivalent to 747 (m5U747) in 23S rRNA (m5U859 in the P.abyssi numbering).
Interaction partners:
- tRNA
- Transport protein, permease
- Predicted ATPases of PP-loop superfamily
- prolyl oligopeptidase
Sequence:
MRGIIKGVSNDGLGVLGEVLVPFAYPGDVVEVISTRERFGRTIARDFKLVKSSPIRVPGKCRYFGRCGGCLWQGLKYREQLKLKEEIFKRVTGVEAEIKGSPRIWFFRNISNFIVTVNGIGFKEFGMPRTVVSVDECPVFSERTKLYIRAMKRFLRETGLNPWNWKNGDVHYLQVREGKFTGEVMINVIAHIPPSGREELTEAFGFADSVYWSLKRDKRDDPKGIPTLIKGNEFIRESIEGLVYLIHPSTFFQTNSYALPILLKAVESFAEGSKVLDLYSGVGTFSLYLAKKGFEVTGVEVNEESVRVAKKSAEVNSLDVSFIPGRAEDAKLKGYETLIVDPPRKGLKDFSKRIAKEGPENLIYVSCNPSKFVLDYRNYLSKAYKIEDAVLIDMFPHTPHVEAVVKLRRR
Protein: Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (NCBP 20 kDa subunit) (CBP20) (Q9P383)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the CBC complex, which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Nuclear cap-binding protein subunit 1
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- U1 small nuclear ribonucleoprotein C
- Pre-mRNA-processing factor 39
- Small nuclear ribonucleoprotein E
- mRNA export factor mex67
- Small nuclear ribonucleoprotein Sm D1
- U1 snRNP-associated protein usp107
- Small nuclear ribonucleoprotein Sm D2
- U2 small nuclear ribonucleoprotein A'
Sequence:
MASITRLDAVSPYLIRRFKNDLRALDAVKQSNCVYVGNLSFYTTEEQIYALFSKCGEIRRIIMGVDRFTKTPCGFCFVEYFENQDALDSLKYISRTSLDERIIRADLDHGYEEGRQYGRGASGGQVRDEMREEFDPGRGGYAKNRQPTSSRQLANYSGISSAPLGSSLELQSNPRYNRWKKN
Protein: Heat shock 70 kDa protein BIP3 (BiP chaperone BIP-L) (Heat shock 70 kDa protein 13) (Heat shock protein 70-13) (AtHsp70-13) (Hsp70 protein BiP chaperone BIP-L) (Luminal-binding protein 3) (AtBP3) (BiP3) (Q8H1B3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). Required for pollen development and pollen tube growth. May be required for the early stages of female gametophyte development, but not for polar nuclei fusion during female gametophyte. Possesses ATPase activity in vitro.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:23624714}. Nucleus {ECO:0000305}.
Interaction partners:
- Heat shock 70 kDa protein 17
- Serine/threonine-protein kinase/endoribonuclease IRE1b
- Serine/threonine-protein kinase/endoribonuclease IRE1a
- Calnexin homolog 1
- DnaJ protein ERDJ2A
- DnaJ protein ERDJ3A
- Endoplasmin homolog
- Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like
- DnaJ protein ERDJ3B
- Calreticulin-2
Sequence:
MIFIKENTAKMTRNKAIACLVFLTVLDFLMNIGAALMSSLAIEGEEQKLGTVIGIDLGTTYSCVGVYHNKHVEIIANDQGNRITPSWVAFTDTERLIGEAAKNQAAKNPERTIFDPKRLIGRKFDDPDVQRDIKFLPYKVVNKDGKPYIQVKVKGEEKLFSPEEISAMILTKMKETAEAFLGKKIKDAVITVPAYFNDAQRQATKDAGAIAGLNVVRIINEPTGAAIAYGLDKKGGESNILVYDLGGGTFDVSILTIDNGVFEVLSTSGDTHLGGEDFDHRVMDYFIKLVKKKYNKDISKDHKALGKLRRECELAKRSLSNQHQVRVEIESLFDGVDFSEPLTRARFEELNMDLFKKTMEPVKKALKDAGLKKSDIDEIVLVGGSTRIPKVQQMLKDFFDGKEPSKGTNPDEAVAYGAAVQGGVLSGEGGEETQNILLLDVAPLSLGIETVGGVMTNIIPRNTVIPTKKSQVFTTYQDQQTTVTINVYEGERSMTKDNRELGKFDLTGILPAPRGVPQIEVTFEVDANGILQVKAEDKVAKTSQSITITNDKGRLTEEEIEEMIREAEEFAEEDKIMKEKIDARNKLETYVYNMKSTVADKEKLAKKISDEDKEKMEGVLKEALEWLEENVNAEKEDYDEKLKEVELVCDPVIKSVYEKTEGENEDDDGDDHDEL
Protein: histone deacetylase (EC 3.5.1.98) (Q8T6T4)
Organism: Trypanosoma brucei
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSVRERNKNPWAHGRQLDLDGDVTVRCQADPRLCTTAAIRRGKLVEPVDQVALRVGVEASGVESLVDAQGITFFGSLKNGMEVFVSGPAMLDAAKTDNDNSDLFLPDVSVAWAYDPRVLEHVPPVDRVPETPYRLQRAVEALRSAPRAAHFLPMELQSSGERSPPREGAPVGTGATAGETPSAAPSGTPLWIPPRLATLDEVTLCHNIHRYRCFIEEGTALLPPLKTDVYCNGKTSSIATRLSVGAVVDAARRALSGSPAFAFCLVRPPGHHASADTPSGFCLVNNVAIAAMQLLQDWHVKYDCGVGGSRSVPSEERDIPERPRIAIVDIDVHHGEGTQSFVEVEPQLLYLSLHRYDRGSFYPCDPAGATSYVGQHRNICNVAVDTAATDPARCEEVISDMLFARVVDDVFLPRLEQFHPNIILLSLGFDAAHGDPLGRMAVEGGFAYVVRALKRFCLQSQGTIGLVAVLEGGYSPEGVSRGVVSVAHALCYPFDDVAVVNYARLRTPKTWMELRSRLSRRMEVRTDETGGATSLSSGLSSQGLGDATSTERAIADDDVLMERHVAWCDKLVKRVLAIHAESNIIK
Protein: Conidial yellow pigment biosynthesis polyketide synthase (PKS) (EC 2.3.1.-) (Q03149)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Non-reducing polyketide synthase that condenses acetate units to form a heptaketide naphthopyrene YWA1, a yellow pigment found in mature asexual spores (conidia), via a polyketomethylene intermediate step.
Interaction partners:
- Laccase-1
Sequence:
MEDPYRVYLFGDQTGDFEVGLRRLLQAKNHSLLSSFLQRSYHAVRQEISHLPPSERSTFPRFTSIGDLLARHCESPGNPAIESVLTCIYQLGCFINYYGDLGHTFPSHSQSQLVGLCTGLLSCAAVSCASNIGELLKPAVEVVVVALRLGLCVYRVRKLFGQDQAAPLSWSALVSGLSESEGTSLIDKFTRRNVIPPSSRPYISAVCANTLTISGPPVVLNQFLDTFISGKNKAVMVPIHGPFHASHLYEKRDVEWILKSCNVETIRNHKPRIPVLSSNTGELIVVENMEGFLKIALEEILLRQMSWDKVTDSCISILKSVGDNKPKKLLPISSTATQSLFNSLKKSNLVNIEVDGGISDFAAETQLVNQTGRAELSKIAIIGMSGRFPEADSPQDFWNLLYKGLDVHRKVPEDRWDADAHVDLTGTATNTSKVPYGCWIREPGLFDPRFFNMSPREALQADPAQRLALLTAYEALEGAGFVPDSTPSTQRDRVGIFYGMTSDDYREVNSGQDIDTYFIPGGNRAFTPGRINYYFKFSGPSVSVDTACSSSLAAIHLACNSIWRNDCDTAITGGVNILTNPDNHAGLDRGHFLSRTGNCNTFDDGADGYCRADGVGTVVLKRLEDALADNDPILGVINGAYTNHSAEAVSITRPHVGAQAFIFKKLLNEANVDPKNISYIEMHGTGTQAGDAVEMQSVLDVFAPDHRRGPGQSLHLGSAKSNIGHGESASGVTSLVKVLLMMKENMIPPHCGIKTKINHNFPTDLAQRNVHIALQPTAWNRPSFGKRQIFLNNFSAAGGNTALLLEDGPVSDPEGEDKRRTHVITLSARSQTALQNNIDALCQYISEQEKTFGVKDSNALPSLAYTTTARRIHHPFRVTAIGSSFQEMRDSLIASSRKEFVAVPAKTPGIGFLFTGQGAQYAAMGKQLYEDCSHFRSAIEHLDCISQGQDLPSILPLVDGSLPLSELSPVVVQLGTTCVQMALSSFWASLGITPSFVLGHSLGDFAAMNAAGVLSTSDTIYACGRRAQLLTERCQPGTHAMLAIKAPLVEVKQLLNEKVHDMACINSPSETVISGPKSSIDELSRACSEKGLKSTILTVPYAFHSAQVEPILEDLEKALQGITFNKPSVPFVSALLGEVITEAGSNILNAEYLVRHCRETVNFLSAFEAVRNAKLGGDQTLWLEVGPHTVCSGMVKATLGPQTTTMASLRRDEDTWKVLSNSLSSLYLAGVDINWKQYHQDFSSSHRVLPLPTYKWDLKNYWIPYRNNFCLTKGSSMSAASASLQPTFLTTSAQRVVESRDDGLTATVVVHNDIADPDLNRVIQGHKVNGAALCPSSLYADSAQTLAEYLIEKYKPELKGSGLDVCNVTVPKPLIAKTGKEQFRISATANWVDKHVSVQVFSVTAEGKKLIDHAHCEVKLFDCMAADLEWKRGSYLVKRSIELLENSAVKGDAHRLRRGMVYKLFSALVDYDENYQSIREVILDSEHHEATALVKFQAPQANFHRNPYWIDSFGHLSGFIMNASDGTDSKSQVFVNHGWDSMRCLKKFSADVTYRTYVRMQPWRDSIWAGNVYIFEGDDIIAVFGGVKFQALSRKILDIALPPAGLSKAQTSPIQSSAPQKPIETAKPTSRPAPPVTMKSFVKKSAGPSVVVRALNILASEVGLSESDMSDDLVFADYGVDSLLSLTVTGKYREELNLDMDSSVFIEHPTVGDFKRFVTQLSPSVASDSSSTDRESEYSFNGDSCSGLSSPASPGTVSPPNEKVIQIHENGTMKEIRAIIADEIGVSADEIKSDENLNELGMDSLLSLTVLGKIRESLDMDLPGEFFIENQTLDQIETALDLKPKAVPTAVPQSQPITLPQSQSTKQLSTRPTSSSDNHPPATSILLQGNPRTASKTLFLFPDGSGSATSYATIPGVSPNVAVYGLNCPYMKAPEKLTCSLDSLTTPYLAEIRRRQPTGPYNLGGWSAGGICAYDAARKLVLQQGEIVETLLLLDTPFPIGLEKLPPRLYSFFNSIGLFGEGKAAPPAWLLPHFLAFIDSLDAYKAVPLPFNEQEWKGKLPKTYLVWAKDGVCPKPGDPWPEPAEDGSKDPREMVWLLSNRTDLGPNGWDTLVGKENIGGITVIHDANHFTMTKGEKAKELATFMKNALGVCERRLV
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Q6JHV3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQSPPHLAVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHLQNLENSAFTADRHKKRKLLENSTLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEGRWFHFNDSTVTLTDEETVVKAKAYILFYVEHQAKAGSDKL
Protein: Melanocyte protein PMEL (115 kDa melanosomal matrix protein) (Melanocyte protein Pmel 17) (Premelanosome protein) (Silver locus protein homolog) (Q98917)
Organism: Gallus gallus (Chicken)
Function: Might be required for polymerization of melanin onto the core structure of melanosomes with enzymatic function of tyrosinase.
Subcellular location: Melanosome lumen. Note=On the fibrous matrix structure of the premelanosome.
Interaction partners:
- Tyrosinase
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
- Melan-A
- Uncharacterized protein.
- BHLH domain-containing protein.
- L-dopachrome tautomerase
- Sodium/potassium/calcium exchanger 5
- Melanocyte-stimulating hormone receptor
Sequence:
MRLHGAIVLLAALLALVTAQQRGGGRSRGGVKGSAWGGRPAPFRSWDTARYRPWQEGTARQNDCWRGGDVTFDISNDAPTLVGARATFSIALRFPGTQTVLPDGRVVWSQNCTVNGTRMLQGDPVYPEQLAEGSDGVFPDGQPFPRSAWGKRGRFVYVWWTWGRYWQVVDGATSQLTVGTDGVALGSYTMEVVVYHYRGRQRFIPIGHASTQFSITDQVPIAVDVTQLEVAAGDGGSFVRNRPVAFNVRLHDPSHYLRDADISYSWDFGDQSGTLISRSPTVTHTYLQAGSFAARLVLQAAIPLSSCGTSAPPVVDPTTGPVPSLGPTATQPVGPTGSGTATAPSNLTGSGTAAAPGTTAAPRASGAPAEPTGVSVAVLSDSAATEPLPDPVLSTAVADAAAGTDPTADPLPPTSVSSGGDAPGTVAPTAVEGSVAAGVGTAEDVAAATPGATAADVAVDTAGATDGDAVGPTAAATAESIADPTAGATDGDAVGATAESIADPTAGATDGDAVGPTAAATAESIADPTAGATAVSSGSATAGATAEPLLLVKRQAPEAEPTGCVLYRYGTFSTELNIVQGIESVAIVQVVPAAPEGSGNSVELTVTCEGSLPEEVCTVVADAECRTAQMQTCSAVAPAPGCQLVLRQDFNQSGLYCLNVSLANGNGLAVASTHVAVGGASPAASGTTLTVGLLWAPLIAAALGTAAYTYRRVKYSPLLPTAPTAPRPHSWLPPGATLRLLLRQAFGGAPSGESSPLLRANAV
Protein: Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Q8RWU6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in trafficking to the vacuole. Required for cell proliferation and cell expansion, but not for cell differentiation. Acts in low affinity electroneutral exchange of protons for cations such as Na(+) or K(+) across membranes (By similarity). May also exchange Li(+) and Cs(+) with a lower affinity (By similarity).
Subcellular location: Endosome membrane {ECO:0000269|PubMed:21278129}; Multi-pass membrane protein {ECO:0000269|PubMed:21278129}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:21278129}; Multi-pass membrane protein {ECO:0000269|PubMed:21278129}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21278129}; Multi-pass membrane protein {ECO:0000269|PubMed:21278129}.
Interaction partners:
- K
- K
- K
- Sodium transporter HKT1
- Calcineurin B-like protein 4
- GPN-loop GTPase QQT1
- F-actin-capping protein subunit alpha
- K
- V-type proton ATPase subunit a1
- 1-phosphatidylinositol 4-kinase
Sequence:
MSSELQISPAIHDPQGQEKQQQAAGVGILLQIMMLVLSFVLGHVLRRHKFYYLPEASASLLIGLIVGGLANISNTETSIRTWFNFHDEFFFLFLLPPIIFQSGFSLQPKPFFSNFGAIVTFSVLGTFVASMVTGLLVYLGGVMFLMYRLPFVECLMFGSLISATDPVTVLSIFQELGSDVNLYALVFGESVLNDAMAISLYRTMSLVRSHSSGQNFFMVIVRFLETFVGSMSAGVGVGFTSALLFKYAGLDVDNLQNLECCLFVLFPYFSYMLAEGLSLSGIVSILFTGIVMKHYTYSNLSANSQRFVSAFFHLISSLAETFVFIYMGFDIAMEKHSWSHLGFIFFSILFIVIARAANVFGCGYLVNLARPAHRKIPMTHQKALWYSGLRGAMAFALALQSVHDLPEGHGQTIFTATTAIVVLTVLLIGGSTGTMLEALEVVGDSHDTSLGDGFEVVNSRYMTSYDDEDTPPGSGFRTKLREFHKSAASFTELDRNYLTPFFTSNNGDYDDEGNMEQHHEERIPFTRRGNLNNRG
Protein: 2-amino-4-deoxychorismate dehydrogenase (ADIC dehydrogenase) (EC 1.3.8.16) (Q8GMH2)
Organism: Streptomyces globisporus
Function: Converts 2-amino-4-deoxychorismate (ADIC) to 3-O-enolpyruvoylanthranilic acid (OPA). Involved in the biosynthesis of the benzoxazolinate moiety of the enediyne antitumor antibiotic C-1027.
Interaction partners:
Sequence:
MSAQLKILAINGSERDGNTADVLRHAARVAENRGVDFEAVDLRSIRMERCGPCGDCNDRPVACTLADGVPEVVAKMVAADGIIFAAPVHGFGTASLMQTFIERAGVGYLRFDRPLSNKVAGIISVARRYSAGEVWAQLTVNALLNRMILVGSGFPATVHALHRGDALKDEEGLTNVSRLVERMTDMIELLDEHRRLTGRSDVLASNEVNERVGLALNELQAQP
Protein: Periplasmic protein TorT (P38683)
Organism: Escherichia coli (strain K12)
Function: Upon binding a putative inducer it probably interacts with TorS and allows it to play a role in the induction of the torCAD operon for trimethylamine N-oxide reductase.
Subcellular location: Periplasm.
Interaction partners:
- Sensor protein TorS
- TorCAD operon transcriptional regulatory protein TorR
- Cytochrome c-type protein TorC
- Trimethylamine-N-oxide reductase 1
- Signal transduction histidine-protein kinase BarA
- Sensor protein EvgS
- Aerobic respiration control sensor protein ArcB
Sequence:
MRVLLFLLLSLFMLPAFSADNLLRWHDAQHFTVQASTPLKAKRAWKLCALYPSLKDSYWLSLNYGMQEAARRYGVDLKVLEAGGYSQLATQQAQIDQCKQWGAEAILLGSSTTSFPDLQKQVASLPVIELVNAIDAPQVKSRVGVPWFQMGYQPGRYLVQWAHGKPLNVLLMPGPDNAGGSKEMVEGFRAAIAGSPVRIVDIALGDNDIEIQRNLLQEMLERHPEIDVVAGTAIAAEAAMGEGRNLKTPLTVVSFYLSHQVYRGLKRGRVIMAASDQMVWQGELAVEQAIRQLQGQSVSDNVSPPILVLTPKNADREHIRRSLSPGGFRPVYFYQHTSAAKK
Protein: DNA (cytosine-5-)-methyltransferase M.ApeKI (M.ApeKI) (EC 2.1.1.37) (Cytosine-specific methyltransferase ApeKI) (Modification methylase ApeKI) (Type II methyltransferase M.ApeKI) (Q9YDP3)
Organism: Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Function: Cytosine methylase that recognizes the double-stranded sequence 5'-GC(A/T)GC-3', methylates C-5 position of the second cytosine on both strands, and protects the DNA from cleavage by the ApeKI endonuclease.
Interaction partners:
- DNA
- Adenosylhomocysteinase
- Arginine decarboxylase proenzyme
- S-adenosylmethionine decarboxylase proenzyme
- S-adenosylmethionine synthase
- CopG family transcriptional regulator
Sequence:
MSRYSTISLFSGAGGLDLGFVQSGRFRIVFANEILLPAAVTYSRNLGLRLEVCGDEPRVEAQPGTIMACDVAKLDFTGLSGVDADVIIGGPPCQDFSIVRGPDWDRRGINVKRGRLYAHFVRALASLQPKAFVFENVPGLVSANRGLAYKVILEDFARLSIRWDEIKRIVSSNGNGGKVEGYEIVFTGIVDFSKLGVPQKRERLVIIGLRKDLAGGGFETISRLRARIDHVLSGKRWLLHRYPLTPIEVFEGQPLDRLGDKYKEVMLKWEGVWDEVGTERAFEWKRRVWDRLTFDIISDYLSFNGIKHADKQELEEALMQHEVLLKELGYYGRPVYSLKLPDSTTEPPYEGKAVVERMKRIPPDENHEFVRGTRWEVEGRGISLVYRRIHPLKPSYTVVAYGGGGTHGYHYDRDRATLTLRERARLQTFPDSFLFYGKKPEIRAQIGEAVPPLAAKRIAEALAEVLDAV