wanglab/gogpt-training-data huggingface dataset:
Protein: Glycine N-acyltransferase (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase) (AAc) (Aralkyl acyl-CoA N-acyltransferase) (Aralkyl acyl-CoA:amino acid N-acyltransferase) (Benzoyl-coenzyme A:glycine N-acyltransferase) (Glycine N-benzoyltransferase) (EC 2.3.1.71) (Q91XE0)
Organism: Mus musculus (Mouse)
Function: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q6IB77}.
Interaction partners:
- Glycine N-acyltransferase-like protein Keg1
- Aldo-keto reductase family 1 member D1
- Bile acid-CoA:amino acid N-acyltransferase
Sequence:
MIVPLQGAQMLQMLEKSLRKYLPESLKVYGTVYHMIHGNPFNLKALVDKWPDFNTVVVRPQEQEMTDDLDFYINTYQVYSKDPQNCQEFLESSEVINWKQHLQIQSSQSHLNKTIQNLASIQSFQIKHSENILYVSSETIKKLFPSLLDTKNLSTGSGKPKAIDQDKFKLSSLDVVHAALVNKFWLFGGNERSQRFIERCIKNFPSSCVLGPEGTPASWTLMDQTGEMRMGGTMPEYRLQGLVSFVVHSQDQIMTKRGYPVYSHTEKSNIAMQKMSYTLQHLPMPCAWNQWKCMPM
Protein: FBD-associated F-box protein At1g66310 (Q9C8Y6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cysteine/Histidine-rich C1 domain family protein
- F-box protein At2g20380
- F-box/kelch-repeat protein At2g22030
- F-box/kelch-repeat protein At2g43270
- Putative F-box protein At3g22940
- F-box protein At2g07140
- Putative F-box/kelch-repeat protein At1g60570
- F-box protein At3g08750
- F-box/kelch-repeat protein At4g29370
- Putative F-box only protein 10
Sequence:
MDQDGEKRVRAKQSDDEVDWLRDLPESLLCHILLNLPTKDVVKTSVLSSKWRNLWRLVPGLDLDSSDFTENNTFVSFIDRFMSFHSDLYLKKFKLRFFCNLNGDEVSENAHIARWINDVVKRKVHNLDLTWGAVEIPPILYLCNSLVSLKLCGVTLPNLELTSLPCVKVIVLEWVKFANDLALEMLISGCLVLESLTLCRRPNDNVKILRVSSQSLLRFSYNGSSYKGLHDDLVLEINAPKLKILKLFSHQLTTSFIRNTSSSIVEADINIGLGKKFDPKDLPKRNVICNFLAGISSVKNLFIAPCTLEVIYDYSRCEPLPLFCNLSYLSVDFYNNSWEILPIFLESCPNLKSLVVGSITSPKRRTSVLSGPRRLLSSLEYVEIESPLTGEVFEMKLVSYLLENSPILKKLTINLDDSSRKKAECELLTIPRRSTSCQVVVL
Protein: Anterior gradient protein 2 (XAG-2) (Secreted protein np77) (P55869)
Organism: Xenopus laevis (African clawed frog)
Function: Involved in cement gland formation; probably specifies dorsal ectoderm to acquire an anterior fate such as cement gland and forebrain. Signals via the FGF pathway.
Subcellular location: Secreted {ECO:0000269|PubMed:9533957}.
Interaction partners:
Sequence:
MQTGLSLACLVLLCSVLGEAALRKPKRQAGATDTNGAAKSEPAPVKTKGLKTLDRGWGEDIEWAQTYEEGLAKARENNKPLMVIHHLEDCPYSIALKKAFVADKMAQKLAQEDFIMLNLVHPVADENQSPDGHYVPRVIFIDPSLTVRSDLKGRYGNKLYAYDADDIPELITNMKKAKSFLKTEL
Protein: Transcription elongation factor SPT5 (Chromatin elongation factor SPT5) (P27692)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
Subcellular location: Nucleus {ECO:0000269|PubMed:14576278}. Mitochondrion {ECO:0000269|PubMed:14576278}. Chromosome {ECO:0000269|PubMed:19683497}. Note=Associates with the coding region of HTA1. {ECO:0000269|PubMed:19683497}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB1
- Transcription elongation factor SPT6
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerase II subunit RPB7
- FACT complex subunit POB3
- RNA polymerase-associated protein RTF1
- Transcription elongation factor S-II
- DNA-directed RNA polymerase II subunit RPB3
- Transcription elongation factor SPT4
- Cell division control protein 73
Sequence:
MSDNSDTNVSMQDHDQQFADPVVVPQSTDTKDENTSDKDTVDSGNVTTTESTERAESTSNIPPLDGEEKEAKSEPQQPEDNAETAATEQVSSSNGPATDDAQATLNTDSSEANEIVKKEEGSDERKRPREEDTKNSDGDTKDEGDNKDEDDDEDDDDDDDDEDDDDEAPTKRRRQERNRFLDIEAEVSDDEDEDEDEEDSELVREGFITHGDDEDDEASAPGARRDDRLHRQLDQDLNKTSEEDAQRLAKELRERYGRSSSKQYRAAAQDGYVPQRFLLPSVDTATIWGVRCRPGKEKELIRKLLKKKFNLDRAMGKKKLKILSIFQRDNYTGRIYIEAPKQSVIEKFCNGVPDIYISQKLLIPVQELPLLLKPNKSDDVALEEGSYVRIKRGIYKGDLAMVDQISENNLEVMLKIVPRLDYGKFDEIDPTTQQRKSRRPTFAHRAPPQLFNPTMALRLDQANLYKRDDRHFTYKNEDYIDGYLYKSFRIQHVETKNIQPTVEELARFGSKEGAVDLTSVSQSIKKAQAAKVTFQPGDRIEVLNGEQRGSKGIVTRTTKDIATIKLNGFTTPLEFPISTLRKIFEPGDHVTVINGEHQGDAGLVLMVEQGQVTFMSTQTSREVTITANNLSKSIDTTATSSEYALHDIVELSAKNVACIIQAGHDIFKVIDETGKVSTITKGSILSKINTARARVSSVDANGNEIKIGDTIVEKVGSRREGQVLYIQTQQIFVVSKKIVENAGVFVVNPSNVEAVASKDNMLSNKMDLSKMNPEIISKMGPPSSKTFQQPIQSRGGREVALGKTVRIRSAGYKGQLGIVKDVNGDKATVELHSKNKHITIDKHKLTYYNREGGEGITYDELVNRRGRVPQARMGPSYVSAPRNMATGGIAAGAAATSSGLSGGMTPGWSSFDGGKTPAVNAHGGSGGGGVSSWGGASTWGGQGNGGASAWGGAGGGASAWGGQGTGATSTWGGASAWGNKSSWGGASTWASGGESNGAMSTWGGTGDRSAYGGASTWGGNNNNKSTRDGGASAWGNQDDGNRSAWNNQGNKSNYGGNSTWGGH
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q57Z11)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Kinesin, putative
- BTB domain-containing protein
- Serine/threonine protein phosphatase 2a regulatory subunit, putative
- Serine/threonine-protein phosphatase 4 regulatory subunit 4
- Serine/threonine-protein phosphatase 4 regulatory subunit 1
- Protein phosphatase 2A regulatory subunit, putative
- Uncharacterized protein
- GP-PDE domain-containing protein
Sequence:
MDPPNVPPSPQAPPDLSPPSGSLSFRADNLVTLEMVQAVTINREKLSEWHHKIRSRLFPLVTGFFVRCRVEDSTDGRALYKVGRIKTLKTDWSVELDLLTTDEILSGRSNTNYDCISNAKLTAGEFSAFISKVPPELLSNISNTVHKMEERLRMMETIILTEPAFHGRRRDDRRQQEAQPAQAVTGLPDKYVFSQNVLLCDDEFSTFPMTVTIVDLLQNAVGQKGMTEPDTPRAGISAITGPKSRAFDEAVASHSTMLQLQDVRNYINSPTQPPVDAARLIEMIRRSSNAQNTSFSYDNLTEFCKLVISVCSQCREVVAKEPLFIRLKSPVTVFGDIHGNFADMAYFLDKVVAFDDIMLKYTTSHLLFLGDYVDRGAFSVECVMYLFALKVISPSKVTLLRGNHESPEVNGDMDVYGYSSFKYQCLDKFGRDRGIDVWVAVNEVFQFLPVIADIDKKIFCVHGGLPQYSGGEDKRLEILSDPSFPRIPVVQCTDPTNVAQRMMVNDLLWSDPAPPNHQLDKYGFGPNPRGPDIKTFGSRAVDMFCERYNYQYIFRAHQEKADGVRLSDNARVVTIFSTSDYAGHQNGAGCILVANGKMRMAIKKPHRHEMKETKGPVSPRTLSKSVPGMIPRLKRI
Protein: Family with sequence similarity 20 member C,-like (Novel protein similar to H.sapiens family with sequence similarity 20) (B0V1R7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MRVCTRRRSLTLRVWLFIVFLSLHLLVVSLVLSVYHTSCELPSTYGIQTTQNASTSEITMATTRSVSKEMKMVDPTGDLAKLDALFSHPLYNLPTPPVPDGDWLLKVRTKVKEQERSTQQWVSANDDGFDPILWNTSTDTHPPWLRFHLGISRWQMYQHKDPNLSALNQQLASHRIVSAVQKSGGTQLKLVMSFPNYGQALFKPMKQERHEETNVNLYYFSDFERHNAEIAAFHLDRILGFRRIPPVIGRLINVIKEIKEVTTDHKLVTTFFNSPVGNTCFHGHCSYYCSTEHAVCGRPIKLEGSLAVMLPDLSLAPRHSWRSPWRRSYSRTNQAEWETNSNYCDTVKQTPPYDRGTRLVDVIDMSILDFLMSNMDRHHYETFEKFGNDTFLIHLDNGRAFGRHSKDEPSILAPLVQCCRVRRSTLLRLRLLSLPPYRLSDVMRASLSRDPLAEVAPLLTEPHLSALDRRLETVMQAIQDCLQQHQHHSDVIYDDIMDYPQA
Protein: Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma) (Q80ZM7)
Organism: Mus musculus (Mouse)
Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription initiation factor IIA subunit 1
- TATA-box-binding protein
- General transcription factor IIE subunit 2
- Transcription initiation factor IIB
- General transcription factor IIF subunit 1
- General transcription factor IIF subunit 2
- General transcription factor IIH subunit 3
- General transcription factor IIE subunit 1
- General transcription factor IIH subunit 2
- TFIIA-alpha and beta-like factor
Sequence:
MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINSALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE
Protein: Ferric uptake regulation protein (Q7VHS0)
Organism: Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Bifunctional DNA-directed RNA polymerase subunit beta-beta'
- Transcriptional regulator
Sequence:
MNMNANHRVETLDSILERLRSSIKKNGLKNSKQREEIIAVLYKSGTHLSPEEITNIIKTTDKNASISSVYRILSFLEKEGFITALEADKSGRRYEIAAKEHHDHIICLACGDIIEFVDADIERLQLDIAQQFGAKLISHDMRLFVKCSKCQGL
Protein: At5g48490 (Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein) (Q9LV65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Dirigent protein 11
- Dirigent protein 1
- Non-specific lipid transfer protein GPI-anchored 6
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
Sequence:
MTSKKVAIMVIVMVMASLVVERSVAIDLCGMTQAELNECLPAVSKNNPTSPSLLCCNALKHADYTCLCGYKNSPWLGSFGVDPKLASSLPKECDLTNAPTC
Protein: Choriogonadotropin subunit beta 3 (Choriogonadotropin subunit beta) (CG-beta) (Chorionic gonadotropin chain beta) (P0DN86)
Organism: Homo sapiens (Human)
Function: Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Subcellular location: Secreted {ECO:0000269|PubMed:16123088}.
Interaction partners:
- Glycoprotein hormones alpha chain
- Lutropin-choriogonadotropic hormone receptor
- Transcription factor AP-2-alpha
- Transcription factor AP-2 gamma
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Probable non-functional immunoglobulin heavy variable 3-16
- Histidine--tRNA ligase, cytoplasmic
- Histidine--tRNA ligase, mitochondrial
- Follitropin subunit beta
Sequence:
MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ
Protein: Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) (Q8N4Q1)
Organism: Homo sapiens (Human)
Function: Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes. Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake.
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:16185709, ECO:0000269|PubMed:23186364, ECO:0000269|PubMed:23676665, ECO:0000269|PubMed:26004228}.
Interaction partners:
- FAD-linked sulfhydryl oxidase ALR
- Cytochrome c oxidase copper chaperone
- Mitochondrial import inner membrane translocase subunit Tim10
- Mitochondrial import inner membrane translocase subunit Tim8 A
- Mitochondrial import inner membrane translocase subunit Tim9
- Mitochondrial import inner membrane translocase subunit Tim13
- Calcium uptake protein 1, mitochondrial
- Mitochondrial inner membrane protease ATP23 homolog
- Mitochondrial import inner membrane translocase subunit Tim10 B
- Cytochrome c oxidase assembly protein COX19
Sequence:
MSYCRQEGKDRIIFVTKEDHETPSSAELVADDPNDPYEEHGLILPNGNINWNCPCLGGMASGPCGEQFKSAFSCFHYSTEEIKGSDCVDQFRAMQECMQKYPDLYPQEDEDEEEEREKKPAEQAEETAPIEATATKEEEGSS
Protein: Antithrombin-III (Serpin C1) (Q5M7T5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
- Prothrombin
- Coagulation factor X
- Coagulation factor IX
- Coagulation factor XII
- Plasminogen
- Fibrinogen alpha chain
- Fibrinogen beta chain
- Protein AMBP
- Vitamin K-dependent protein C
- Fibrinogen gamma chain
Sequence:
MYSPGIGSAVAGERKLCLLSLLLIGALGCAVCHGNPVDDICIAKPRDIPVNPMCIYRSPAKKATEEDVLEQKVPEATNRRVWELSKANSRFATNFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNNTLKQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSNLVSANRLFGDKSLTFNESYQDVSEIVYGAKLQPLDFKENPEQSRVTINNWVANKTEGRIKDVIPQGAIDELTALVLVNTIYFKGLWKSKFSPENTRKEPFHKVDGQSCLVPMMYQEGKFKYRRVGEGTQVLEMPFKGDDITMVLILPKPEKSLAKVEQELTPELLQEWLDELSEVMLVVHVPRFRIEDSFSLKEQLQDMGLVDLFSPEKSQLPGIIAEGRDDLFVSDAFHKAFLEVNEEGSEAAASTSVVITGRSLNPSRVTFKANRPFLVLIREVALNTIIFMGRVSNPCVN
Protein: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) (Q9SSL0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alpha-glucan phosphorylase 1
- Starch synthase 3, chloroplastic/amyloplastic
- Anthranilate N-hydroxycinnamoyl/benzoyltransferase-like protein
- Probable phosphoglucomutase, cytoplasmic 2
- Ornithine transcarbamylase, chloroplastic
- 5-amino-6-
- Probable starch synthase 4, chloroplastic/amyloplastic
- Glutamine--fructose-6-phosphate aminotransferase 1
- Probable pectate lyase 12
- Probable protein phosphatase 2C 62
Sequence:
MASTSTSSLMASKTVISKTALFSSLPGIVSRSFLTFAPASPSVKPLRIRSSNVTKFDEVTNSLDEDMDQIRRLQNGSDVRGVALEGEKGRTVDLTPAAVEAIAESFGEWVAATESNGNGVIKISLGRDPRVSGGKLSTAVFAGLARAGCLAFDMGLATTPACFMSTLLSPFEYDASIMMTASHLPYTRNGLKFFTKRGGLTSPEVEKICDLAARKYATRQTKVSTLIRTRPQQVDFMSAYSKHLREIIKERINHPEHYDTPLKGFQIVVNAGNGSGGFFTWDVLDKLGADTFGSLYLNPDGMFPNHIPNPENKIAMQHTRAAVLENSADLGVVFDTDVDRSGVVDNKGNPINGDKLIALMSAIVLKEHPGSTVVTDARTSMGLTRFITERGGRHCLYRVGYRNVIDKGVELNKDGIETHLMMETSGHGAVKENHFLDDGAYMVVKIIIEMVRMRLAGSNEGIGSLIEDLEEPLEAVELRLNILSEPRDAKAKGIEAIETFRQYIEEGKLKGWELGTCGDCWVTEGCLVDSNDHPSAIDAHMYRARVSDEESGEEYGWVHMRQSIHNPNIALNMQSMLPGGCLSMTRIFRDQFLEASGVARFLDISDFDNYIGGQS
Protein: Autophagy-related protein 9 (I1S9X9)
Organism: Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)
Function: Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence. Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant. Required for aerial hyphae development and lipid droplet degradation in response to starvation.
Subcellular location: Preautophagosomal structure membrane {ECO:0000250|UniProtKB:Q12142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12142}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q12142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12142}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q12142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12142}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q12142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12142}.
Interaction partners:
- Serine/threonine-protein kinase ATG1
- Autophagy-related protein 18
- Autophagy-related protein 2
- Autophagy-related protein 11
- Autophagy-related protein 17
- Autophagy-related protein 13
- Chromosome 3, complete genome
- Autophagy-related protein 27
- Vacuolar protein sorting-associated protein 30
- Phosphatidylinositol 3-kinase VPS34
Sequence:
MASNIFSRIKSPSGGSQSFYQQLRSGEDPEYDPGLDEENLGHRFDDFQAEGMDIGDSSMTVESVAPGSKGKGKATFRPTAHARSSGITSPRWQQDDDGDNEVPASLLMEPKDLDPPASPPNKRATNPGSSRTPASVGPSSARTRAQWEAATAQQQLHQDHPYTTPMGPQPIPVARGTMSNNPREKALWRWVNTSNLDSFMRDVYDYFEGGGLWCILCANALWLFQCIDYSRVPDSRSLHEVIVPQCTRKMSGLWNFAIWLYTFFFIWKCVQYFVEIRRLTYIRDFYIYLLDIPEQDMQTISWQDVVARIMALREENPKTATNISPRLRQFMGSQSKERLDALDIANRLMRKENYLIAMINKDILDLSLPVPFLRGRQMFSKTMEWYLQYCILDMAFNELGQVQQDFLRPDRRRLLSQKLRQRFLFAGFLNLLFAPVVLAYVVIVYFFTYYYEYQKDPKQAAARKYTSLAEWKFRQFNELPHIFYERLHMSYPFATRYIDQFPKRITEAVARTIAFMSGAITAILAIGSVLDSELFLNFEITKDRPVIFYLGVFAAIWATTRGMVSEETLVFNPEYALRNVIEYTRYVPDHWKNKLHSSEVKQEFSELYKMKVVIFLEEMMGIVTTPMLLLFSLPRCSDQIVDFFREFTIHVDGLGYVCSFAVFDFQKGPGNTGPQGPRPDVREDYYSTKHGKMAASYYGFLDNYAANPKTGIPGHLPPGPKPSFHPPPSFPGIGSPTLAADMQGSHIGRTGTETGRARSRAPGGRGPRIGVMPQPSPMASMLLDQHHQPPGGNMVARSLHASRYPRGYRGESQIIEETEASSIRRNGEDDELYEPGGALGESVWETSPARGVTRENSAANTEDPEAGVLGLIYQLQQTQRPRRGGGMV
Protein: Thiol peroxidase (Tpx) (EC 1.11.1.24) (Peroxiredoxin tpx) (Prx) (Thioredoxin peroxidase) (Thioredoxin-dependent peroxiredoxin) (P57668)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Interaction partners:
- Superoxide dismutase
- Glutathione reductase
- NAD
- Alkyl hydroperoxide reductase C
- Superoxide dismutase
Sequence:
MAQVTLKGNPVNVDGQLPQKGAQAPAFSLVGGDLADVTLENFAGKRKVLNIFPSVDTPTCATSVRKFNVEAGKLANTVVLCISADLPFAQKRFCGAEGLENVVNLSTLRGREFLENYGVAIASGPLAGLAARAVVVLDEQNKVLHSELVGEIADEPNYAAALAAL
Protein: H2.0-like homeobox protein (Homeobox protein HB24) (Homeobox protein HLX1) (Q14774)
Organism: Homo sapiens (Human)
Function: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- T-box transcription factor TBX21
- Transducin-like enhancer protein 2
- Transducin-like enhancer protein 4
Sequence:
MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSFCIADILHAGVGDLGAAPEGLAGASAAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGTRVVPNPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLSGLQPSAGQFFASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAADGEQDERSPSRSEGEAESESSDSESLDMAPSDTERTEGSERSLHQTTVIKAPVTGALITASSAGSGGSSGGGGNSFSFSSASSLSSSSTSAGCASSLGGGGASELLPATQPTASSAPKSPEPAQGALGCL
Protein: Sodium myo-inositol transporter 1 (Q80WA5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRAVLETADIAIVALYFVLVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLLLYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMVISMMKVGGFEEVKRRYMLASPNVASILLTHNLSNTNSCMVHPKADALKMLRDPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFVDDIACINPEHCMQVCGSRAGCSNIAYPRLVMELVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLLRNNASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAIRLILAFTYRAPECDQPDNRPSFIKDIHYMYVATALFWITGLITVIVSLLTPPPTKDQIRTTTFWSKKTVVTKESCSQKDEPYKMQEKSILRCSENSEVVSHTIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASMGHSGAETPVDAYSNGQAALMGERAREKETESRSRYWKFIDWFCGFKSRSLSKRSLRDSMDEEAVCLQMLEETPRVRVILNIGLFAVCSLGIFMFVYFSL
Protein: Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Q6IMZ0)
Organism: Rattus norvegicus (Rat)
Function: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- Nuclear receptor subfamily 1 group D member 1
- Period circadian protein homolog 2
- Period circadian protein homolog 3
- Basic helix-loop-helix ARNT-like protein 1
- Cryptochrome-1
- Nuclear receptor subfamily 1 group D member 2
- Cryptochrome-2
- Neuronal PAS domain protein 2
- Hepatic leukemia factor
- Circadian locomoter output cycles protein kaput
Sequence:
MQLRKMQAIKKEPASLDPTGSSDKMLLLNSALAEVAEDLASGEDLLLNEGSMGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTVYAQEIQKLSNSTAVYFQDYQTSKAAVSSYVDEHEPAMVAGSCISVIKHSPQSSLSDVSEVSSVEHTQESPAQGGCRSPENKFPVIKQEPVELESFARESREERGAYSASIYQSYMGSSFSTYSHSPPLLQVHGSTSNSPRTSEADEGVVGKSSDGEDEQQVPKGPIHSPVELQRVHATVVKVPEVNPSALPHKLRIKAKAMQVKVEALDSEFEGMQKLSSPADALAKRHFDLEKHGASGTAHSSLPPFSVQVTNIQDWSLRSEHWHHKELGGKTQGTFKTGVVEVKDSGYKVSEAENLYLKQGVANLSAEVVSLKRFIATQPISASDSR
Protein: Kinase (EC 2.7.-.-) (M9ND56)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSLLKFLAINALELSAPATPHLLQHQQAHKQAKPQGWMQLSGHPESIVPTSTGIVRKRISGLEDSEVHAYRLICKEPQTAQIVPAYFGIQEMQSQHFIELQDLLAGFRDPCVMDIKMGSRTFLESEVSNATLRPDLYQKMIAVDAGAPTPAEHEARAITKLRYMTFRESLSSSHSKGFRIEALRLRGRPPVKDLKTCRSSEQIAQTIEQFLAARRSVQKELLKRLKHMRLVIEQSTFFASHEIIGSSIFIVYDDDRVGVWLIDFAKCRELPPHVRVDHRSAWAPGNREEGLLRGMDELIRSFEEVYARCGSHRSCLKI
Protein: Voltage-gated sodium channel (Q9ESV8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
ILMCMSNLPEWILAVENTLLGIYTFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRSSPLSSLPMFKTIRTLRILKIIPLNHGLQSIVVTLVQCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKHKCVRWPQEDGNDVMYNGT
Protein: CFEM2 (G8BIM4)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MDNNWSTYPSVAKTASINGFADRIYDLVPQCAQECLKESTGSTPCPYWDTGCLCIMPQFAGAIGNCVAENCQGQNVVQFESLATSLCSSAGVWEPYWMPPASVTTALSTAAAAEAAETTPASTEEEQSSSAPAETSAPETTAQETSAAEESSSAPAETSAPAESSSAPAESSAPAESSQEEKPSSAEEQSSSSAPAEGEGEGEGEATVSTVNGGVIPGVAMGGVIAALAALI