wanglab/gogpt-training-data huggingface dataset:
Protein: Natural killer cell receptor Ly-49P1 (Natural killer cell receptor Ly49P1) (Q9EPB6)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSEQEVTFSTVRFQKTSGLQNRVRLEETLKPRKAGLRVCSVPWQFIVIALGILISLRLVIVAVLVTNIFQYGQQKHELQEFLNHHNNCSIMQSDIKLKDELLKKKSIECNLLESLNRDQNRLYSKTKTVLDFLQHTGRGDKVYWFCYGRKCYYFVMDRKPWSGCKQTCQSSGLSLLKIDDEDELKFLQLVVPSDVCWIGLSYDNKKKDWSWVDNGPSKLALNTRKYNIRDGGCMLLSKTRLDNGNCDQVFICICAKRLDKFPH
Protein: Immunoglobulin lambda variable 3-1 (Ig lambda chain V-IV region Bau) (Ig lambda chain V-IV region MOL) (Ig lambda chain V-IV region X) (P01715)
Organism: Homo sapiens (Human)
Function: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular location: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
Interaction partners:
Sequence:
MAWIPLFLGVLAYCTGSVASYELTQPPSVSVSPGQTASITCSGDKLGDKYACWYQQKPGQSPVLVIYQDSKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTAH
Protein: Uncharacterized mitochondrial carrier C83.13 (P78763)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Probable citrate synthase, mitochondrial
- ATP synthase subunit g, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- ATP synthase subunit K
- Syntaxin-like protein psy1
- Plasma membrane ATPase 2
- ATP synthase subunit f
- Mitochondrial import inner membrane translocase subunit tim17
Sequence:
MSKIEKKQASASNLLLGAGLNLFETSSLGQPLEVTKVQMAANRTQTMAQAIKAIMSRGGILGFYQGLIPWAWIEASTKGAVLLFTSAELEYWGRRLGLGATSAGAIAGMGGGVAQAYATMGFCTCMKTAEVTRAKQAATGQEVKGTFRVFADLYKEKGIRGINRGVNAVALRQMTNWGSRLALSRFLEKPIRYFTGRTEAEPLTTGQRFVASVSAGALSCWNQPLEVARVEMQSLTKGIQHSSPGIMQTIMSIYKNNGIKGLYRGAVPRMGLGAYQTFVMVFLADCVRGYLAK
Protein: Cyclin-D5-1 (G1/S-specific cyclin-D5-1) (CycD5;1) (Q2V3B2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cyclin-dependent kinase A-1
- Cyclin-dependent kinases regulatory subunit 2
- Cyclin-dependent kinase B1-1
- Retinoblastoma-related protein 1
- Cyclin-dependent kinases regulatory subunit 1
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinase B2-2
- Cyclin-dependent kinase B2-1
- Cyclin-dependent protein kinase inhibitor SMR8
- Cyclin-B1-3
Sequence:
MGEPKDSLALFLCHESESSLNEDDDETIERSDKQEPHFTTTIDDEDYVADLVLKENLRFETLPSKTTSSSDRLIAIDWILTTRTRFGFQHQTAYIAISYFDLFLHKRFIGLQKDETWAMRLLSVACLSLAAKMEERIVPGLSQYPQDHDFVFKPDVIRKTELLILSTLDWKMNLITPFHYFNYFLAKISQDNHSVSKDLVLLRSSDSLLALTKEISFTEYRQFVVAAVTTLLASSSTSSDIRLTREEIANKFGSISWWTSNENENVYLCYQRTLEIEERKHMTPPPEIAVSREPPASGSGAKRRLSFDDSDQSSPPAKRMRRL
Protein: Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) (Q9CSB4)
Organism: Mus musculus (Mouse)
Function: Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions (By similarity).
Subcellular location: Endomembrane system {ECO:0000250}. Cell junction {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions (By similarity). {ECO:0000250}.
Interaction partners:
- Protein kinase C zeta type
- Protein kinase C iota type
- Partitioning defective 6 homolog alpha
- Partitioning defective 6 homolog beta
- Partitioning defective 6 homolog gamma
Sequence:
MKVTVCFGRTGIVVPCKDGQLRVRELTQQALQRYLKTRDQDPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFDEQEPLQKTESPGGNPADRQSPDAFETEVAAQLAAFKPVGGEIVVTPSALKLGTPLLVRRSSDPAPGPHADAQPSTASLSGQSLKPVVLDSTQNVENKEAMNGEQAGLLSLHRPKDELSDMTRAVEISGEGDPLGIHVVPFFSSLSGRILGLFIRGIEENSRCKQEGLFQENECIVKINNVELLDKTFAQAQDVFRQAMKSPSVILHVLLPQNREQYEKSVIGPLNIFGNNDGASRTKAAPPARGKPGLKAVHLTRASSPEGEEPASPQQSKSPRVPRLGRKPSSPSLSPLMGFGSKKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAVKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETVSLVIARQEGSFLPRELKGEPDCYALSLESSEQLTLEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGETLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPLEELSECGALSRPGFENCQEALSTSRRNDSSILYPFGTYSPQDKRKDLLLPSDGWAENEVPPSPPPHPALEWGLEDFSHSSGVDSTGYFPDQHVNFRTVTPVRQPELINLKASKSMDLVPDEGKVQSLADRRSDSPGKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEADADGLSDKSSRSGHTALNCESAPQGNPELDNVENKAKNIKKTKEKEKKKGKGKLKVKEKKLKEEHEDAERKMKRKGFGAMLRFGKKKDDKVGKAEQKGAQKSGHPEEEELERMKEERERIGAKHQELREKQARGLVDYATAVTGPVHDMDDDEMDPNYARVNHFREPCASANVFRSPSPLRAGPLAYPRDGRPLSPDHLEGLYAKVNKPYHPPALADSGRPMAGTTDRIQKLRKEYYQARREGFLLYEDENTRARPSDHDLRWVSGKGPDGSTHNLRFEGMERQYASLPRGGSADPVDYLTASPRGRYNDRELPYYPGPHPVHAPRGSYPRPPDLRATDLRYPQYYPPPPAHQHKGPFRQDVPPSPPQHQRVPVYQEMGRAGPRGSSPDQYPYRNQDPRQKNPMTAAV
Protein: Syntaxin, Qa-SNARE family (Q8IIW1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Alpha-soluble NSF attachment protein, putative
- Protein transport protein SEC22
- SNARE protein, putative
- SNARE protein, putative
- SNARE protein, putative
- Syntaxin-6, putative
- Vacuolar protein sorting-associated protein 33, putative
- Vacuolar protein sorting-associated protein 16, putative
- Vesicle-fusing ATPase
- Vacuolar protein sorting-associated protein 18, putative
Sequence:
MSYSNKKKEYKKFSNKNVMSFEFNSDIQNDIGVIKSYTSRISRINDDEPYSIESSEKVQEIVQEGKLKIQEIQKKLKNYRNITENVPQHEKVRVKLMLQRLSNSYLEAVNNFQNASKNYINKTIMNDLSTKNYNVEENMEYDSLNNFSRKSNSNYDTNIDKYNVNIYDYNFYENNYETSYSKYNNSTEFQSVDSTIEEKTYKKKKKYKSNIFTGDKKNEVNEYLLENNNYEQENNNYGQEKQFVSINTVDIENEILTQKNKEIKKLHKDIINIQELYKELFEQINIQGENIDNIDSQMVNTHDNIMMSGREIEIARNRYFSSLRCTIYLLFLILILVIIILVVFRII
Protein: Kinesin-like protein KIF12 (Q96FN5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Kinesin-associated protein 3
Sequence:
MEERGSPDGDLARSLEQGPEGPETPIQVVLRVRPMSAAELRRGQQSVLHCSGTRTLQGGPEVAFRFGAVLDAARTQEDVFRACGVRRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQGEGVPVPPSLAGIMQRTFAWLLDRVQHLGAPVTLRASYLEIYNEQVRDLLSLGSPRPLPVRWNKTRGFYVEQLRVVEFGSLEALMELLQTGLSRRRNSAHTLNQASSRSHALLTLYISRQTAQQMPSVDPGEPPVGGKLCFVDLAGSEKVAATGSRGELMLEANSINRSLLALGHCISLLLDPQRKQSHIPFRDSKLTKLLADSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRVTTRPQAPKSPVAKQPQRLETEMLQLQEENRRLQFQLDQMDCKASGLSGARVAWAQRNLYGMLQEFMLENERLRKEKSQLQNSRDLAQNEQRILAQQVHALERRLLSACYHHQQGPGLTPPCPCLMAPAPPCHALPPLYSCPCCHICPLCRVPLAHWACLPGEHHLPQVLDPEASGGRPPSARPPPWAPPCSPGSAKCPRERSHSDWTQTRVLAEMLTEEEVVPSAPPLPVRPPKTSPGLRGGAGVPNLAQRLEALRDQIGSSLRRGRSQPPCSEGARSPGQVLPPH
Protein: DNA ligase 1 (AtLIG1) (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) (Q42572)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein. DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Involved in repair of both single strand breaks (SSBs) and double strand breaks (DSBs). Required in the endosperm for embryogenesis, probably to repair DNA-breaks generated by DME.
Subcellular location: [Isoform 1]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus.
Interaction partners:
- DNA-repair protein XRCC1
- Flap endonuclease 1
- DNA polymerase lambda
- ATP-dependent DNA helicase 2 subunit KU80
- ATP-dependent DNA helicase 2 subunit KU70
- Polynucleotide 3'-phosphatase ZDP
- Proliferating cell nuclear antigen 2
- Proliferating cellular nuclear antigen 1
- DNA repair protein XRCC4
- N-glycosylase/DNA lyase OGG1
Sequence:
MLAIRSSNYLRCIPSLCTKTQISQFSSVLISFSRQISHLRLSSCHRAMSSSRPSAFDALMSNARAAAKKKTPQTTNLSRSPNKRKIGETQDANLGKTIVSEGTLPKTEDLLEPVSDSANPRSDTSSIAEDSKTGAKKAKTLSKTDEMKSKIGLLKKKPNDFDPEKMSCWEKGERVPFLFVALAFDLISNESGRIVITDILCNMLRTVIATTPEDLVATVYLSANEIAPAHEGVELGIGESTIIKAISEAFGRTEDHVKKQNTELGDLGLVAKGSRSTQTMMFKPEPLTVVKVFDTFRQIAKESGKDSNEKKKNRMKALLVATTDCEPLYLTRLLQAKLRLGFSGQTVLAALGQAAVYNEEHSKPPPNTKSPLEEAAKIVKQVFTVLPVYDIIVPALLSGGVWNLPKTCNFTLGVPIGPMLAKPTKGVAEILNKFQDIVFTCEYKYDGERAQIHFMEDGTFEIYSRNAERNTGKYPDVALALSRLKKPSVKSFILDCEVVAFDREKKKILPFQILSTRARKNVNVNDIKVGVCIFAFDMLYLNGQQLIQENLKIRREKLYESFEEDPGYFQFATAVTSNDIDEIQKFLDASVDVGCEGLIIKTLDSDATYEPAKRSNNWLKLKKDYMDSIGDSVDLVPIAAFHGRGKRTGVYGAFLLACYDVDKEEFQSICKIGTGFSDAMLDERSSSLRSQVIATPKQYYRVGDSLNPDVWFEPTEVWEVKAADLTISPVHRAATGIVDPDKGISLRFPRLLRVREDKKPEEATSSEQIADLYQAQKHNHPSNEVKGDDD
Protein: GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) (Q96S15)
Organism: Homo sapiens (Human)
Function: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:28199306}.
Interaction partners:
- Nucleoporin SEH1
- GATOR1 complex protein NPRL2
- GATOR1 complex protein NPRL3
- GATOR2 complex protein WDR59
- KICSTOR complex protein kaptin
- Ras-related GTP-binding protein B
- GATOR1 complex protein DEPDC5
- GATOR2 complex protein MIOS
- Ras-related GTP-binding protein C
- Protein SEC13 homolog
Sequence:
MEKMSRVTTALGGSVLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLVAAESGRKPYTGDRRHPIFFKRKLDPAEPFAGLASSALSVFETEPGGGGMRWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPTANLNHSVGKGGSCGLPLMNSFNLKDMAPGLGSETRLDRSKGDARSDTVLLDSSATLITNEDNEETEGSDVPADYLLGDVEGEEDELYLLDPEHAHPEDPECVLPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGSEADVASLAPVDSSFSLLSVSHALYDSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS
Protein: UDP-glycosyltransferase 76D1 (EC 2.4.1.-) (O48715)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses low quercetin 7-O-glucosyltransferase activity in vitro.
Interaction partners:
Sequence:
MAEIRQRRVLMVPAPFQGHLPSMMNLASYLSSQGFSITIVRNEFNFKDISHNFPGIKFFTIKDGLSESDVKSLGLLEFVLELNSVCEPLLKEFLTNHDDVVDFIIYDEFVYFPRRVAEDMNLPKMVFSPSSAATSISRCVLMENQSNGLLPPQDARSQLEETVPEFHPFRFKDLPFTAYGSMERLMILYENVSNRASSSGIIHNSSDCLENSFITTAQEKWGVPVYPVGPLHMTNSAMSCPSLFEEERNCLEWLEKQETSSVIYISMGSLAMTQDIEAVEMAMGFVQSNQPFLWVIRPGSINGQESLDFLPEQFNQTVTDGRGFVVKWAPQKEVLRHRAVGGFWNHGGWNSCLESISSGVPMICRPYSGDQRVNTRLMSHVWQTAYEIEGELERGAVEMAVRRLIVDQEGQEMRMRATILKEEVEASVTTEGSSHNSLNNLVHAIMMQIDEQ
Protein: Myelin expression factor 2 (MEF-2) (MyEF-2) (Q8C854)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA.
Subcellular location: Nucleus.
Interaction partners:
- Pre-mRNA-splicing factor SYF1
- Heterogeneous nuclear ribonucleoprotein M
Sequence:
MADADKSEAAAGDDGSQQQPAEPRRDTHPGEPEKPPRSSANGVKMENDESVKEEKSDLKEKSTGNKKANRFHPYSKDKNSGTGEKKGPNRNRVFISNIPYDMKWQAIKDLMREKVGEVTYVELFKDAEGKSRGCGVVEFKDEEFVKKALETMNKYDLSGRPLNIKEDPDGENARRALQRTGTSFQGSHASDVGSGLVNLPPSILNNPNIPPEVISNLQAGRLGSTIFVANLDFKVGWKKLKEVFSIAGTVKRADIKEDKDGKSRGMGTVTFEQAIEAVQAISMFNGQFLFDRPMHVKMDDKSVPHEDYRSHDSKTSQLPRGLGGIGMGLGPGGQPISASQLNITGVMGNLGPSGMGMDGPGFGGVNRIGGGVGFGGLEAMNSMAGFGGVGRMGELYRGAMTSSMERDFGRGDIGLSRGFGDSFGRLGSAMIGGFAGRIGASNMGPVGTGISGSMSGMSTVTGGMGMGLDRMSSSFDRMGPGIGAILERSIDVDRGFLSGPMGSGMRDRLGSKGNQIFVRNLPFDLTWQKLKEKFSQCGHVMFAEIKMENGKSKGCGTVRFESAESAEKACRIMNGIKISGREIDVRLDRNA
Protein: Transforming growth factor-beta-induced protein ig-h3 (A0A8I6AMY6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MHLDCRGQSDRPKLVGASADPLASCSLVGSPNVCAVQKVIGTNKKYFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETLGIVGSTTTQLYTDRTEKLRPEMEGPGSFTIFAPSNEAWSSLPAEVLDSLVSNVNIELLNALRYHMVDRRVLTDELKHGMALTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTVTNNIQQIIEIEDTFETLRAAVAASGLNTVLEGDGQFTLLAPTNEAFEKIPAETLNRILGDPEALRDLLNNHILKTAMCAEAIVAGMAMETLGGTTLEVGCSGDMLTINGKAVISNKDILATNGVIHFIDELLIPDSAKTLLELASESDVSTAIDLLRQAGLSTHLSGKEQLTFLAPLNSVFKDGVPRIDGQMKTLLLNHMVKGQLASKYLYSGQTLDTLGGKKLRVFVYRNSLCIENSCIAAHDKKGRYGTLFTMDRMLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLMETLNREGVYTVFAPTNEAFQAMPPEELNKLLANAKELTNILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSSKNNVVSVNKEPVAETDIMATNGVVYAINTVLQPPANRPQERGEELADSALEIFKKASAYSRSAQSSMRLAPVYQRLLERMKRRG
Protein: Zinc transporter 1 (ZRT/IRT-like protein 1) (OsZIP1) (Q94DG6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Zinc transporter that may mediate zinc uptake from the rhizosphere. May also transport other divalent cations.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MARTMTMRVSSLLVAVVLLAALSFQACSGHGGINDGDGQVDAPATPASSSGVRSKGLIAVKVWCLVILLVFTFAGGVSPYFYRWNESFLLLGTQFAAGVFLGTALMHFLADSTSTFKGLTTNQYPFSFMLTCVGFLLTMLSDLVIAAVARRSAAAGVSDNQVSEQQQRQQAEGAVMSRKEEEAAAVAHPAMLVRTSSFEDAVLLIVALCFHSVFEGIAIGVSASKSEAWRNLWTIGLHKIFAAVAMGIALLRMIPKRPFLMTVVYSLAFAVSSPVGVGIGIAIDATSQGRAADWTYAISMGLATGVFIYVAINHLIAKGYRPHHPTAADKPLFKFLAVLLGVAVMAVVMIWD
Protein: UPF0494 membrane protein C1348.01 (P0CS86)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Copper-binding regulatory protein cuf2
- Putative fatty acid elongase 1
- Meiotic expression up-regulated protein 14
Sequence:
MSNPESLKKQVEPPGYNELFMVEDVCNVDLEQGLDLCKPEKVNKQSQRSRQSRQSLFTNTIKPQKDKMNIKTNKIKEFLNDLFTEFSKFHNSYYPDGRISTRSNFRWPLLIIWSIIIVFAVDKKFEVQKFLSIWINENRFYSEIWVPIAIYVCLLVLMLLSLIFFAEFAVLALRVTGVIIAVLGMIIAVLGMIIAALGATITGLLYFGHWALYKLVILSLGFKIVTPGDVCVSNTLPTHNGETALHSETTVGSDIEQIELQNMPTPVKK
Protein: External NADH-ubiquinone oxidoreductase 1, mitochondrial (EC 1.6.5.9) (External NADH dehydrogenase 1) (P40215)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE2, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxidation.
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:14576278}.
Interaction partners:
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- D-lactate dehydrogenase [cytochrome] 1, mitochondrial
- L-lactate dehydrogenase
- External NADH-ubiquinone oxidoreductase 2, mitochondrial
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 2
- Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial
- Cytochrome c isoform 1
Sequence:
MIRQSLMKTVWANSSRFSLQSKSGLVKYAKNRSFHAARNLLEDKKVILQKVAPTTGVVAKQSFFKRTGKFTLKALLYSALAGTAYVSYSLYREANPSTQVPQSDTFPNGSKRKTLVILGSGWGSVSLLKNLDTTLYNVVVVSPRNYFLFTPLLPSTPVGTIELKSIVEPVRTIARRSHGEVHYYEAEAYDVDPENKTIKVKSSAKNNDYDLDLKYDYLVVGVGAQPNTFGTPGVYEYSSFLKEISDAQEIRLKIMSSIEKAASLSPKDPERARLLSFVVVGGGPTGVEFAAELRDYVDQDLRKWMPELSKEIKVTLVEALPNILNMFDKYLVDYAQDLFKEEKIDLRLKTMVKKVDATTITAKTGDGDIENIPYGVLVWATGNAPREVSKNLMTKLEEQDSRRGLLIDNKLQLLGAKGSIFAIGDCTFHPGLFPTAQVAHQEGEYLAQYFKKAYKIDQLNWKMTHAKDDSEVARLKNQIVKTQSQIEDFKYNHKGALAYIGSDKAIADLAVGEAKYRLAGSFTFLFWKSAYLAMCLSFRNRVLVAMDWAKVYFLGRDSSI
Protein: Synaptopodin 2 (H0Y9Y3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
XGDEVVSINGNPCADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAEELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVHINSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCRLQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDKMEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSESGRSLSLPGRSVPPPISTSPWVYQPTYSYSSKPTDGLEKANKRPTPWEAAAKSPLGLVDDAFQPRNIQESIVANVVSAARRKVLPGPPEDWNERLSYIPQTQKAYMGSCGRQEYNVTANNNMSTTSQYGSQLPYAYYRQASRNDSAIMSMETRSDYCLPVADYNYNPHPRGWRRQT
Protein: Cell division control protein (A8KC19)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR001767}.
Interaction partners:
Sequence:
MPSTRSQNQPTLQFPRRKSSRLGSRPKSSCENKVDDKTTPLSPRKAIVGNSLGVCQSPRNKVLNSPLSERLPLSPRKRTGDENGCNLPASMLGSPPKQRCAPLCSPRKLSFNENTPVLSSPPRPILSSHKVPLSPISRPSPTRLNETSCTNIIPRTEGKSPVMRLFPMKKSGFQSVKQALHTAVPERLLSREAERAAIVSFLQNHVVAEKPSSLYISGAPGTGKTACLNCVLQEQKALLKGIQTVVINCMNLRSSHAIFPLLGEQLEVPKGNSQARLEKYLTSSGPTVLLVLDEMDQLDSKSQEVLYTIFEWPYLPKSRVCLIGIANALDLTDRILPRLQAKPHCRPKLLNFPPYSHEELNAIVQDRLTQVSGEGVLDAAAVQFCARKVSAVSGDARKALDICRRAVEIVEAGDRSKMASEPTASSKVSRVSVPQVARVLSEVYGDRMASSSGDGESFPLQQKLLVCCLLLIIRNGKSKEIQLGKLCEVYSKLCKQRQVGGVGQTECLSLCSLLESRGILTLKKAKDARLTKISLKIEERDVEHALKDRTLLGSILAAGLP
Protein: Histone deacetylase complex subunit (F4HP43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- F22L4.11 protein)
- At1g31750
- At5g65925
- NADH dehydrogenase iron-sulfur protein 5-B
- Peter Pan-like protein
- non-specific serine/threonine protein kinase
- Protein SHI RELATED SEQUENCE 8
- Probable lysophospholipase BODYGUARD 2
- Probable envelope ADP,ATP carrier protein, chloroplastic
- Calcium-binding EF-hand family protein
Sequence:
MLEAVDSSGVVNGGFPQIQSFYGDCSSEEELSVLPRHTKVVVTGNNRTKSVLVGLQGVVKKAVGLGGWHWLVLTNGIEVKLQRNALSVLEPPTGNEEDDDLDFENTQRNGSDMIVSFPASEDTLKPHKSKLRGQRSSRSSHKTMSRSLSSDSQSKSSGFTPPENMQKVDLSKLEMPALLNYWRHFNLVDAIPNPSKEQLIDIVQRHFMSQQMDELQVIVGFVQAAKRMKKACKFQSKESRNTDLNCIS
Protein: Catechol O-methyltransferase (EC 2.1.1.6) (P21964)
Organism: Homo sapiens (Human)
Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Subcellular location: [Isoform Soluble]: Cytoplasm {ECO:0000269|PubMed:11559542}.; SUBCELLULAR LOCATION: [Isoform Membrane-bound]: Cell membrane {ECO:0000269|PubMed:21846718}; Single-pass type II membrane protein {ECO:0000269|PubMed:21846718}; Extracellular side {ECO:0000269|PubMed:21846718}.
Interaction partners:
- Amine oxidase [flavin-containing] B
- Amine oxidase [flavin-containing] A
- Cytochrome P450 1A1
- Aromatic-L-amino-acid decarboxylase
- Dopamine beta-hydroxylase
- Cytochrome P450 1B1
- Phenylethanolamine N-methyltransferase
- Aldehyde dehydrogenase family 3 member B1
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Sodium-dependent serotonin transporter
Sequence:
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Protein: Protein tas (P0A9T4)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized lipoprotein YgdR
- UPF0053 inner membrane protein YgdQ
- Lysophospholipid transporter LplT
Sequence:
MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQVYTYPAP
Protein: N(5)-(carboxyethyl)ornithine synthase (CEOS) (EC 1.5.1.24) (N(5)-(L-1-carboxyethyl)-L-ornithine:NADP(+) oxidoreductase) (P15244)
Organism: Lactococcus lactis subsp. lactis (Streptococcus lactis)
Function: Catalyzes the NADPH-dependent reductive condensation between pyruvic acid and the side chain amino group of L-ornithine to form N(5)-(L-1-carboxyethyl)-L-ornithine. To a lesser extent, can also use L-lysine as substrate (yielding N(6)-(L-1-carboxyethyl)-L-lysine). NADH cannot replace NADPH in the condensation reaction.
Interaction partners:
Sequence:
MKIGLVKANFPGERRVPLLPKDIKDFKNEILVEEGFGKFLDIDDQEYSDKGCHILSRAEVFAESEAIFSLKLIQPTDYYHLREGQMIIGWTHPFGSGQSFMKEQALPKKLIVVDLDSNSPCIYYENEIFESGIPKGLLYKNSFYAGYAGVLDALLQYGLIPTEETKIAILGSGNVAQGAFSSISKYSSNIRMYYRKTMSIFKENYTKYDIIINGIEIGKDDDPILSFSEQKSLKKGTLIIDVAADAGNTIEGSHFTSIDAPIYENAGKYYYVVPNTPSLIYRNVSQELSKILSENIFRKDCSRFIEKVKPLNK
Protein: K(+) efflux antiporter 4 (AtKEA4) (Q9ZUN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Electroneutral K(+)/H(+) efflux antiporter involved in K(+) homeostasis and osmotic adjustment. Together with KEA5 and KEA6, promotes growth and development, and facilitates endosomal pH and ions homeostasis, as well as salt tolerance (e.g. K(+), NaCl and LiCl), probably by supporting cell wall biosynthesis during rapid etiolated seedling growth.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:30255504, ECO:0000269|PubMed:30309966}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:30309966}; Multi-pass membrane protein {ECO:0000255}. Prevacuolar compartment membrane {ECO:0000269|PubMed:30309966}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000269|PubMed:30309966}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cation/H
- Sodium/hydrogen exchanger 5
- Sodium/hydrogen exchanger 6
- F-actin-capping protein subunit alpha
- Sodium/hydrogen exchanger 8
- Sodium/hydrogen exchanger 1
- Cation/H
- Potassium transporter 3
- Cation/H
- Cation/H
Sequence:
MRRCKNNTDKFSVITMRLLTLLLICTFFFFFSFAYSAESDNETDSVVTREINGTVVESNATSAKPREDSFADMIDRALEKEFPDNDQNEVPDPGSFNNSVADQQAVLETVARVKPKKNETKTKEEKSFFNLDNENGVEDTPRLIDRKDNVFIMSNPKSKYPVLQLDLRLISDLVVVIVSATCGGIAFACAGQPVITGYLLAGSIIGPGGLSFVSEMVQVETVAQFGVIFLLFALGLEFSAAKLRVVRAVAIPGGLLQIFLFMCLSGITASLCGGKLTEGIFVGAFLSMSSTAVVLKFLMERNSISALHGQITVGTLILQDCAVGLLFALLPVLGGTSGVLQGVLSMAKSLAILIAFLGALFVLSRTWVPWFLKLMTSLSSQTNELYQLAAVAFCLLVAWCSDKLGLSLELGSFAAGVMISTTDLAQHTLEQVEPIRNFFAALFLASIGMLIHMHFLWNHVDILLAAVLLVIVIKTVVVAIVVKVFGYNNKTAVLVGMSLAQIGEFAFVLLSRASNLHLIESKLYLLLLGTTALSLVTTPLLFKLIPAVVHLGVLLRWFSPDSSTEIGFKGELYHSESAKRISLMIQGSLHDS