wanglab/gogpt-training-data huggingface dataset:
Protein: G-protein coupled receptor 83 (Glucocorticoid-induced receptor) (P30731)
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN. Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27117253}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with GPR171 in the paraventricular nucleus (PubMed:27117253). Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus (PubMed:23744028). {ECO:0000269|PubMed:23744028, ECO:0000269|PubMed:27117253}.
Interaction partners:
- G-protein coupled receptor 83
- Insulin receptor substrate 4
- Insulin receptor substrate-3
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Insulin receptor substrate 1
- Insulin receptor substrate 2
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Pro-neuropeptide Y
- G-protein coupled receptor 171
- ProSAAS
Sequence:
MKVPPVLLLFLLSSVRATEQPQVVTEHPSMEAALTGPNASSHFWANYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFTIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWVFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRISITKGVIYIAVIWVMATFFSLPHAICQKLFTFKYSEDIVRSLCLPDFPEPADLFWKYLDLATFILLYLLPLFIISVAYARVAKKLWLCNTIGDVTTEQYLALRRKKKTTVKMLVLVVVLFALCWFPLNCYVLLLSSKAIHTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRVELKALLSMCQRPPKPQEDRLPSPVPSFRVAWTEKSHGRRAPLPNHHLPSSQIQSGKTDLSSVEPVVAMS
Protein: Transmembrane protein 138 (Q7YX41)
Organism: Caenorhabditis elegans
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Vacuole membrane {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004128}.
Interaction partners:
- Nephrocystin-1-like protein
- Transmembrane protein 237 homolog
- Transmembrane protein 231
- MecKel-Gruber Syndrome
- TMEM
Sequence:
MTSKYPYVLTTQVFMLSIDILFNALGVLCYGNNMTLLLIYILQDTLLIMSSLVLFVSFTATFVFQLGLIHIVIFQFLPTVIISILYTFVSIGYHYASLSSTWEDRTVNIFMNGPLLLFFIIHKIVSCVFYAYYKRTALQISDPKYNSDSTWLRELFIKHMNDKAAKIEARTAAENN
Protein: Glutathione S-transferase omega (GSTO) (EC 1.20.4.2) (EC 1.8.5.1) (EC 2.5.1.18) (Glutathione-dependent dehydroascorbate reductase) (Monomethylarsonic acid reductase) (C1BG28)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MASEKCFAKGSSAPGLVAKGQIRLYSMRFCPFAHRTRQVLHAKGIKHDTVNINLKDKPEWFLKKNPLGLVPTLETSSGQVIYESPITCDYLDEVYTDKKLLPADPFQKAQQKMMLENFSKVTPYFYKIPMGKKNGEDISVLEGELKEKFVKLNEDLVNKKFFGGNAITMIDYMMWPWFERLEIFELKHCLDGTPELKKWTEHMSEDQTVKATMFPTETYKAFYKTYADGKPNYDYGL
Protein: CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Protein FISP-12) (P29268)
Organism: Mus musculus (Mouse)
Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9184077}. Secreted {ECO:0000269|PubMed:9184077}.
Interaction partners:
- Vascular endothelial growth factor A, long form
- Transforming growth factor beta-1 proprotein
- Decorin
- Fibronectin
- Actin, aortic smooth muscle
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Integrin beta-1
- Insulin-like growth factor 1
- High affinity nerve growth factor receptor
- Fibroblast growth factor 2
Sequence:
MLASVAGPISLALVLLALCTRPAMGQDCSAQCQCAAEAAPHCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDRTAVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA
Protein: Catenin beta 1 (A0A2R8YCH5)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}.
Interaction partners:
Sequence:
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDT
Protein: Oligo-1,6-glucosidase IMA1 (A0A1D8PUB9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Glucoamylase 1
- Glucoamylase 1
- glucan 1,4-alpha-glucosidase
- Glycosyl hydrolase family 13 catalytic domain-containing protein
- Glycogen debranching enzyme
Sequence:
MSEHKWWKEAVVYQIWPASYKDSNGDGVGDIPGIISTLDYIASLGVTTVWLSPMYDSPQDDMGYDVSDYENVYSKYGTLQDMDRLIAGCHDRGLKLILDLVINHTSVEHKWFKESRSSKDNPKRDWYIWKPPRIDSNGNKHPPNNWGSYFSGSAWKYDELTGEYYLHLFAESQPDLNWENKECREAIYNSAIKFWLDKGVDGFRIDTAGMYSKYQHFKDVPVAFPDTEFQPCEIYHKNGPRIHEFHKEMAKVMEPYDTMTVGEVGHSTREQALKYVSAAEKEMNMMFLFDVVELGSDPRDRFRYNGFDLVDLKKAIKSQGEFAEGTDAWSTVFIENHDQARAISRFGNDSPEFRVLSGKAIAMLQCCLTGTLFIYQGQEIGMTNVPRSWPIEEYKDINTINYYRAFKEKYGKDADYKQKEEKLVDVINRLARDNARTPVQWSHQQYAGFSEVEPWMRVNDNYKEINVEDQDGDDHSLLNFYRKLLKLRGEYKDLFVYGEMKFLDFDDKKLFTFAKEAPGSPVAYIVINFSGEDVKFEPLIKGNYKLVLTNVDKDSKDALSPYEARMYVVD
Protein: Developmentally-regulated GTP-binding protein 1 (DRG-1) (xDRG) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-) (P43690)
Organism: Xenopus laevis (African clawed frog)
Function: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (By similarity). Binds to microtubules and promotes microtubule polymerization and bundling. GTPase activity is not necessary for these microtubule-related functions.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y295}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y295}.
Interaction partners:
Sequence:
MSGTLARIAEIEAEMARTQKNKATAYHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVVRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNKQPPNIGFKKKDKGGINLTATCAQSELDNDTVKSILAEYKIHNADITLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLQLVRIYTKPKGQLPDYTSPVVLPCSHTAAEDFCTKIHKNLIKEFKYALVWGSSVKHNPQKVGKDHVLEDEDVIQIVKK
Protein: Repellent protein 1 [Cleaved into: Rep1-1; Rep1-2; Rep1-3; Rep1-4; Rep1-5; Rep1-6; Rep1-7; Rep1-8; Rep1-9; Rep1-10; Rep1-C] (Q99109)
Organism: Mycosarcoma maydis (Corn smut fungus) (Ustilago maydis)
Function: Water-repellent structural protein required for surface hydrophobicity and formation of aerial hyphae during filamentous growth.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:8861956}.
Interaction partners:
Sequence:
MPSKIALSISVLTAALGMVSAAPHYEYKSYNAGHNVESVVENKLVDASDLTLGVDILKRTDYSACKKYVSSYNAGYNVYSINENKLIDLSDATVKLSLLTNNGRPVKTWNKAPRYCLEYIKSYNGGHNVIIDNENKLIDLSGLNLGIDILKRKAPEFSYYNPGHNVKSTTENKLVDASDLLANVNILSKRGDKYSYYNGGYNVESDTENKLIDLSGLLANIDILKKRTGSQYSYYNGGHNVESTNENKLVDASDLLANVDILKKRGDKYTYYNGGHNIESTNENKLIDLSDLTANVGVLDDVHVNIGLLDKRTDKYSYYDGGHNIELTNENKLIDLSDLLANVDVLKKRTDKFSYYNGGHNVESDTQNKLIDVSHLTAIVNALSKRTDKYSYYNGGHNVESTNENKLIDLSDLTALVNVLSKRSLKGYGSKIHARDISEELYRRTNADEDCTCVKKSKPTPPKQTVTKPSADCDAPPAVTPKPKPSTKPSPSPTTPPPSKDTSKPTTKPEPKPQPSDKPEPKPSDKPEPKPSDKPEPKPSDKPEPTPSPKPTPPKVTCGTDEVYVDEGHNVVSKNSNKLLDLSNISINIGILDGLFGGKKSKEVAADSTCTSKQGCCVSKSVYYYNGGNNVQSSNENSGIDLSGLNLGLDIL
Protein: Klaroid, isoform E (A4UZ58)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTPDAKRKQNSITATVTSILTKRSGGATSTPRNRSQLETTQNTLNSAQEKLNQSNGNLSSGNVSDYLAYIEYRDAGEYWNKTPKTDYTYSELSPHRRQLAPGIVAMPNMSRKSLENHNDRVNYMVQQNPAQEEFIRRRYQSKYTQQVNYDSADELDATFGQQKQSWWLIRLIQLVVSSITTVWSRVTNLSATETTAYQNYHAKRQQSQQVGLWWKIVQTIGGGLASLLRYLYVFIGSVLSLDTWLLRSSDAENKSKKRFLIFLLILLPLLLLSGLFYYIHPNETFPPKSLSEYTFTLPELPKIDVKDYLNQEQFESLRSQAAEHAVRVRDWADDYVLYLRTIGQNVVNKGRQLFQGDDKVYYERV
Protein: Exocyst complex component EXO70I (MtExo70I) (Exocyst subunit Exo70 family protein I) (A0A396JG59)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Component of an exocyst subcomplex specifically required for periarbuscular membrane (PAM) biogenesis during arbuscular mycorrhizal (AM) symbiosis with AM fungi (e.g. Glomus versiforme), especially critical during the early branching phase of arbuscule development; probably involved in STR and STR2 delivery into the PAM.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26234213}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=During arbuscule branching, restricted to zones adjacent to the periarbuscular membrane (PAM) around the arbuscule hyphal tips. {ECO:0000269|PubMed:26234213}.
Interaction partners:
Sequence:
MHKKQLMALLMVPQTSDSQDATITKLESAYSDLESLLRSSKQMEQNIETMETRFDLLHGSITTASRRVHPLQSLSMSRKALDTRINRAISPALALLETFKLAESLQNNLLNLSSKLSTEKTHQKRLSKLLDYMDCVDQLNEAINSISEVVEPVIMRLQEVVEFISRTKAADQYRTQRLREALITLKALYETEVDEMRFEGLLDQALLHMQDEFEVLLLKLKHRKLGDMSHMQNGGEDCDDHFEVSFELGSELEIEVLRRISNTLAANDCLDICIDIYVKVRYKRAAKALMKLNPDYLRTYTPEGIDEMEWENLETSITLWTQHFEVATKKVLLSEKKLCESVLGEIIDGLIHPECFVKISDKIMAVFFRFGEGVARSNKEPQKLFKLLDMFESLEKLKPYVLEIFDGESGEDICARFRELEKLIIDASSKVFWEFGLQIEGNVDGFLPPPQDGSVPKIVRYAVNYLKYLSTENYRTTMAKVLRTELTWKTELMLSSKQSETDEDLLKHAICNVMEALQRNIESKRLSCKDKILVNIFMMNTYWYMYMRTKNTELGDLLGEKYIKESYKAVAEESAYLYQKQAWLVLVKILDQDDDDIKEQKQGKEKSIGRLVNEKIETFFKCLSEICDRHRSFYSIPDVDLREQMRDSTVKLLVPVYAEFLESYSGFLQRKVYPSPQRLQGLLGKAFGSTNDWNLNGGRNSGSLETDIRRSR
Protein: Selenium-binding protein 2 (Protein EMBRYO SAC DEVELOPMENT ARREST 38) (Q93WN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the fusion of female gametophyte polar nuclei.
Interaction partners:
- Assimilatory sulfite reductase
- Cystathionine gamma-synthase 1, chloroplastic
- Selenium-binding protein 3
- Probable cystathionine gamma-synthase 2
- Selenium-binding protein 1
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 2
- Homocysteine S-methyltransferase 3
- Homocysteine S-methyltransferase 1
- Homocysteine S-methyltransferase 2
- Cystathionine beta-lyase, chloroplastic
Sequence:
MATETVLATAVSNGKSKGCCKSGPGYATPLAAMAGPREKLIYVTALYSGTGRDKPDYLATVDVDPSSPTFSSVIHRLKMPYIGDELHHTGWNSCSSCHGDASADRRYLVLPGLISGRIYAIDTKTDPKAPSLYKVVEPKEIAEKTGLAFPHTSHCLASGDMLVSCLGDKEGNAKGNGFLLLDSDFNVKSRWDKPGHGPLFGYDFWYQPRFKTMISTSWGAPKAFSKGFNLQHVADGLYGSHLHIYQWPEGEMKQIIDLGNTGLLPLEIRFLHDPSKDTGYVGSALSSNMIRFFKNSDDTWSHEVVISVKPLKVENWILPEMPGLITDFLISLDDRFFYFVNWLHGDIRQYNIEDPKNPVLTGQIWVGGLLQKGSPYKAVGEDGNTYQFDVPQIKGKSLRAGPQMIQLSLDGKRLYATNSLFSAWDRQFYPEIMEKGSHIIQIDVDTDKGGLTLNPDFFVDFGDEPDGPALAHEMRYPGGDCTSDIWI
Protein: Sec1 family domain-containing protein 1 (Syntaxin-binding protein 1-like 2) (Q8BRF7)
Organism: Mus musculus (Mouse)
Function: Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- BET1 homolog
- Golgi SNAP receptor complex member 2
- Syntaxin-5
- Synaptobrevin homolog YKT6
- Golgi SNAP receptor complex member 1
- Vesicle-trafficking protein SEC22b
- General vesicular transport factor p115
- Syntaxin-18
- Vesicle-fusing ATPase
- Alpha-soluble NSF attachment protein
Sequence:
MVGSKMAATASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRLCQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDPLGTGQFSFQRPLLVLVDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESTGVENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDVISDPDAGTPEDKMRLFLIYYISAQQAPSEVDLEQYKKALTDAGCNLSPLQYIKQWKAFAKMASTPASYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRSNDSSVPRNKSPFQEAIVFVVGGGNYIEYQNLVDYIKAKQGKHILYGCSEIFNATQFIKQLSQLGQK
Protein: Spermatogenesis-associated protein 31 (Acrosome-expressed protein 1) (B6VQA5)
Organism: Rattus norvegicus (Rat)
Function: May play a role in spermatogenesis.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome lumen {ECO:0000269|PubMed:16924657, ECO:0000269|PubMed:20850414}. Note=Localizes to the inner and outer membranes as well as to the matrix of the acrosome.
Interaction partners:
- Spermatogenesis-associated protein 32
Sequence:
MENLPSLLESIYTTWLSLSSTIWAMDMILAFVCGLGLYLLLLPFLESHLSSSPSDINFTRKPQIQMTWQSQYMKKFRNHCRNDAKAWEECLKKLKEKEKDELFLEEMSPGHHLNSLGNMFNSASAKQDSTTLSPFWNLKEKSEEQMATQKLSYPKISGDHLQEKYDQLYWGLPSLHSESLVAAAWIPQTTSTLPSPFFLFNVISSVYPIHLQDKMSPVLPHTHPLSYLDLQPPPLILSPLEFQSPALNQVHFQSPLPVLLPSSLPYSRDSGACYSQSQSKPHCPTTEIQYRERPLVTKQLESRLTLPLMVQKDAYSILASNPSHDWAVPIFPDNFPISCELRDKLEQHIQKWFIQHQWYFPPEIQESEEVMGLQNSVTGNYQIRDQPCTSQAHMSTGEHNKQGQKVKFQLENESCKNLGPILGKGPKDPVKGLEKNVVKVQGANILEPERNLVKHFKSDSRNDSSNYIDEDLENNWKANFGTKSGQINQGLTPLSMRQSWLAMNDSFCDTDIHMETRNLTAIKSSEKFMCSREKLAFLNPETRQTLEEHVVRFWVKHRWGLPLKMLKPINLFKLKSTESLPLTLCTQPSSTNSVHRTNSAVEVVRFLGKPCLRQIIIKDSSPPPGNLLLVSSPSCKRAAIRRPPSGVDHEPSVALPNKPQSAYLAETLAYNFMETPTQSGGVLKDEMETEEVLLLPRMTCAPNLRAHNPQAKVVSEYPYNVETELTGQPQIYTTSVLLPKHSRSMPLPVDTLTSNALGDIVMVDGGNGLVQQRPSTPKHQVSQKGQIKMLVPTYQGEDTKRQSERKYEDMSKFSPVTERKNNFENQYYQTLPKTTQVLPESLFQRLLSRFLPRVHPKKTIKGQECHPQKDNPTAATAQNQRRQVRKQPYMDDNVTEAQKLMTTVGQMLEKKMMQHQHHASKVNQPRVVPPGPTSWFSHGHMPVSCLKRRRPPSYPANSLCQRRYIQGRHNRGQLPQKSVQFSQKPQILRNPRHMYPKSALNVVNSSQNRTTVPRTPNQHLCCPRHCAFQRNVCRELGHPSVAFPNRKT
Protein: SNS (Q9V4Y0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MALQQQHQRHQQHQQHQQQQQQQQQQQQQHIKWQQHATKRRRCRQHWIKHLQLLRLLAVIVLASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLNSAIRANAKLTVISPPASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKCAPEIAKAPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYIDEARKKAASTYLVEGSDMPPPRYQKDGTLPVNYPNNVVNACTLPHPRHNNGSAAIHMTRDDQMLISKGVYIPSPSPAPPPDGSYYNMNSDRYLSYPPMEYPAALDFTAQPMPMAHLQPMTVTSLATNGGPTLIGNGSVAAVAGGSGTLRRGILRGVVGVPQPDVTHHTSTVGGSPMQMLHDLHPVNLSASTLTTSTTLNGSLPTATATLPRQPHGILKDPNRNKQQQQQQQQQQQQQQQLQHQQQLLNASLVGVGVPVSAPLGSLQILNLPPASGGLGNNLLMTTNAFDPTTVGLSSFGAVSQAGGIPVAYTDADGHLV
Protein: Interleukin-17B (IL-17B) (Cytokine CX1) (Cytokine-like protein ZCYTO7) (Neuronal interleukin-17-related factor) (Q9QXT6)
Organism: Mus musculus (Mouse)
Function: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
Subcellular location: Secreted.
Interaction partners:
- Interleukin-17 receptor B
- Interleukin-25
- Interleukin-17 receptor A
- Interleukin-17 receptor E
- Interleukin-17 receptor D
- Interleukin-17A
- Interleukin-17 receptor C
Sequence:
MDWPHSLLFLLAISIFLAPSHPRNTKGKRKGQGRPSPLAPGPHQVPLDLVSRVKPYARMEEYERNLGEMVAQLRNSSEPAKKKCEVNLQLWLSNKRSLSPWGYSINHDPSRIPADLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPQPPRPGPCRQRVVMETIAVGCTCIF
Protein: Chymopasin (Chymotrypsin A CTRA-1) (Chymotrypsin-like) (MFLJ00366 protein) (Q9ER05)
Organism: Mus musculus (Mouse)
Interaction partners:
- Carboxypeptidase A1
- Bile salt-activated lipase
- Chymotrypsin-like elastase family member 2A
- Chymotrypsin-like elastase family member 3B
- Chymotrypsinogen B
- trypsin
- Carboxypeptidase B
- Anionic trypsin-2
- Trypsin-5
- Colipase
Sequence:
MLLLSLTLSLVLLGSSWGCGVPAITPALSYNQRIVNGENAVPGSWPWQVSLQDNTGFHFCGGSLISPNWVVTAAHCQVTPGRHFVVLGEYDRSSNAEPVQVLSIARAITHPNWNANTMNNDLTLLKLASPARYTAQVSPVCLASTNEALPSGLTCVTTGWGRISGVGNVTPARLQQVVLPLVTVNQCRQYWGARITDAMICAGGSGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNCNIQAPAMYTRVSKFSTWINQVMAYN
Protein: Lipase (EC 3.1.1.3) (EC 3.1.1.32) (Phospholipase A1) (Triacylglycerol lipase) [Cleaved into: Lipase 86 kDa form; Lipase 46 kDa form] (P04635)
Organism: Staphylococcus hyicus
Function: Has a broad substrate specificity hydrolyzing a variety of triglycerides and phosphatidylcholines.
Subcellular location: Secreted {ECO:0000269|PubMed:2611229}.
Interaction partners:
- Diglucosyl diacylglycerol synthase
- Diacylglycerol kinase
- Putative long chain fatty acid-CoA ligase VraA
- Putative long chain fatty acid-CoA ligase VraA
Sequence:
MKETKHQHTFSIRKSAYGAASVMVASCIFVIGGGVAEANDSTTQTTTPLEVAQTSQQETHTHQTPVTSLHTATPEHVDDSKEATPLPEKAESPKTEVTVQPSSHTQEVPALHKKTQQQPAYKDKTVPESTIASKSVESNKATENEMSPVEHHASNVEKREDRLETNETTPPSVDREFSHKIINNTHVNPKTDGQTNVNVDTKTIDTVSPKDDRIDTAQPKQVDVPKENTTAQNKFTSQASDKKPTVKAAPEAVQNPENPKNKDPFVFVHGFTGFVGEVAAKGENHWGGTKANLRNHLRKAGYETYEASVSALASNHERAVELYYYLKGGRVDYGAAHSEKYGHERYGKTYEGVLKDWKPGHPVHFIGHSMGGQTIRLLEHYLRFGDKAEIAYQQQHGGIISELFKGGQDNMVTSITTIATPHNGTHASDDIGNTPTIRNILYSFAQMSSHLGTIDFGMDHWGFKRKDGESLTDYNKRIAESKIWDSEDTGLYDLTREGAEKINQKTELNPNIYYKTYTGVATHETQLGKHIADLGMEFTKILTGNYIGSVDDILWRPNDGLVSEISSQHPSDEKNISVDENSELHKGTWQVMPTMKGWDHSDFIGNDALDTKHSAIELTNFYHSISDYLMRIEKAESTKNA
Protein: Cytokinin dehydrogenase 1 (EC 1.5.99.12) (Cytokinin oxidase 1) (AtCKX1) (CKO 1) (O22213)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group. Catalyzes in vitro the oxidation of various types of cytokinin nucleotides that are known as direct products of cytokinin biosynthesis. Promotes adventitious root initiation downstream of MYC2-dependent jasmonate signaling. Cytokinin degraded by CKX1 is required for cell division in the female gametophyte by modulating the expression of cell cycle genes.
Subcellular location: Vacuole {ECO:0000269|PubMed:14555694}.
Interaction partners:
- Adenylate isopentenyltransferase 3, chloroplastic
- Adenylate isopentenyltransferase 1, chloroplastic
- Adenylate isopentenyltransferase 5, chloroplastic
- Adenylate isopentenyltransferase 7, mitochondrial
- Adenylate isopentenyltransferase 8, chloroplastic
- Histidine kinase 3
- Histidine kinase 2
- Histidine kinase 4
- Cytokinin hydroxylase
- Cytokinin hydroxylase
Sequence:
MGLTSSLRFHRQNNKTFLGIFMILVLSCIPGRTNLCSNHSVSTPKELPSSNPSDIRSSLVSLDLEGYISFDDVHNVAKDFGNRYQLPPLAILHPRSVFDISSMMKHIVHLGSTSNLTVAARGHGHSLQGQALAHQGVVIKMESLRSPDIRIYKGKQPYVDVSGGEIWINILRETLKYGLSPKSWTDYLHLTVGGTLSNAGISGQAFKHGPQINNVYQLEIVTGKGEVVTCSEKRNSELFFSVLGGLGQFGIITRARISLEPAPHMVKWIRVLYSDFSAFSRDQEYLISKEKTFDYVEGFVIINRTDLLNNWRSSFSPNDSTQASRFKSDGKTLYCLEVVKYFNPEEASSMDQETGKLLSELNYIPSTLFSSEVPYIEFLDRVHIAERKLRAKGLWEVPHPWLNLLIPKSSIYQFATEVFNNILTSNNNGPILIYPVNQSKWKKHTSLITPNEDIFYLVAFLPSAVPNSSGKNDLEYLLKQNQRVMNFCAAANLNVKQYLPHYETQKEWKSHFGKRWETFAQRKQAYDPLAILAPGQRIFQKTTGKLSPIQLAKSKATGSPQRYHYASILPKPRTV
Protein: CD9 antigen (CD antigen CD9) (P40240)
Organism: Mus musculus (Mouse)
Function: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. Acts as a receptor for PSG17. Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis (By similarity). Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10518536, ECO:0000269|PubMed:10634791, ECO:0000269|PubMed:11805154, ECO:0000269|PubMed:23213457}; Multi-pass membrane protein {ECO:0000269|PubMed:11805154}. Membrane {ECO:0000269|PubMed:11805154}; Multi-pass membrane protein {ECO:0000269|PubMed:11805154}. Secreted, extracellular exosome {ECO:0000269|PubMed:26109643}. Note=Present at the cell surface of oocytes (PubMed:10518536, PubMed:10634791, PubMed:23213457). Accumulates in the adhesion area between the sperm and egg following interaction between IZUMO1 and its receptor IZUMO1R/JUNO (PubMed:25209248). {ECO:0000269|PubMed:10518536, ECO:0000269|PubMed:10634791, ECO:0000269|PubMed:23213457, ECO:0000269|PubMed:25209248}.
Interaction partners:
- Prostaglandin F2 receptor negative regulator
- Immunoglobulin superfamily member 8
- Tumor susceptibility gene 101 protein
- CD81 antigen
- CD63 antigen
- Integrin beta-1
- Pregnancy specific beta-1-glycoprotein 17
- CD44 antigen
- CD82 antigen
- Integrin alpha-3
Sequence:
MPVKGGSKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNHSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYKDTYQKLRSKDEPQRETLKAIHMALDCCGIAGPLEQFISDTCPKKQLLESFQVKPCPEAISEVFNNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV
Protein: Transcription factor AP2-Z (AP2 transcription factor-related protein 1) (A0A509AJL3)
Organism: Plasmodium berghei (strain Anka)
Function: Transcription factor which binds the 5'-[TC][AC]TG[AT]AC[AG]-3' motif. During the mosquito vector stage, plays an essential role in the zygote for de novo transcription of genes required for ookinete formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:34119684}. Chromosome {ECO:0000269|PubMed:35947628}.
Interaction partners:
Sequence:
MNSKKIEELDKTTNHLDNSRNNMYSCTFMEKGDEDNILNSTILKMNNTEKGISFQTIEEEIKDKNKISNIPSDYAEKEKYCFNELLYTKQNGYINIIEKEDKPIQEILTDDKKNISEIDSSKSDKMDPCLSSQKVDEEYKYGDNYNINGDNPVHNSDEINEDSKCECSFFISKCDYEKDSDANTNGPKKSCKDSEENINYYNNNLLLGISENKDTLIKCDKIFERSYYSTSASTVLASNENEQNLQNISSYETVSSMNEKIKLDGNGKYEKLEKEQTYIMNKETNVINPQDYSIHDIGTYRDECISYLNKIKDIPHNIGSQINSYQNNNIIGNNNFKDKSYLIHENDFFDVETKKKNILQNYFLVNNNNEINANEDMNNRSDDLKNIEAVASDLNEIIEEDTIQKKINISKNCKIEENINMNINDHNKNAVFNFNINRQLFHDNQGDENMYKTNFNTENNKSINIINGMSKEVYEQNSGDIHAQVENINNIEQTTNNIIENNMMIIQGSDDLRFTTLNCINDNSNTDIMKCKRKIKNDENRENIMIKTDQKNIKMKDELDEDDKDELYGIPDKKRRKKNKKKKIPGRVYKVIVRGKECWRAEWLVQKNQENIEREKEESKMDRYSIMKLENTKDVDKNINKMNTPNFQKKSKQFSVSVYGYENARLFALFELIKYNSVPDSLKEEASICIHNIKRNIMNSENSSNKSFSGHFLQFLLADENNEYSSLLYKRLEDNVIQNVNKYSMHEMNNINRMNLFQTQGKEIGFRNEKYFTVQYDNENGHGNNIVDGTIWNIQNNERNLFYNNNNKCRNDYYYNNSNDIIKMKKENNEKLTTFNDNNFYNKANYINRYNNPYVSNNNPSIHNLNNLVYNINSYDFNPMHIRNGYGNDSNSTINISSPNSNYHRGFGEEKDIQKKKNFFNINNTRKYVGDINNKPMDGFKQNLFEKVLNNLENNMGNNNLYNYNSLEHHINSKVKSTYPYNNDNITNDPANTTTMISHGANNNQISNETEIRNSQQILHDNLLVYRNFMNPSSCDIGNVDKNSENDRGEKMASNFEGAFLNKSNIVFKQNANFDPFLGRNVSNINT