wanglab/gogpt-training-data huggingface dataset:
Protein: Serotonin receptor 5-HT1a (Q800U7)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
VTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSSAVTDLMVSVLVLPMAALYQVLNRWTQGQVTCDLFIALDVLC
Protein: NAD(P)-binding domain-containing protein (Q20697)
Organism: Caenorhabditis elegans
Interaction partners:
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- Ground-like domain-containing protein
- UDP-glucose 6-dehydrogenase
- Alkylglycerol monooxygenase
- Alpha-1,3/1,6-mannosyltransferase ALG2
- Probable galactose-1-phosphate uridylyltransferase
- NAD
- UTP--glucose-1-phosphate uridylyltransferase
- UTP--glucose-1-phosphate uridylyltransferase
Sequence:
MGSAWEEPTCVLITGGCGFIGSNYINFTFNKWKNTKFINYDKLAFGASPLHVEKEIRESPRYKFVEAALEDQPTLIKTLQENEVDMVIHFAAITHVDESYSDRIGTIQDNIISTTTLLESIVNSPYKGVKKLVHISTDEVYGDSFEDTTPKSESASLPNPTNPYAASKAACEMVIRSYWHSYKLPYVMVRMNNVYGPRQIHTKLIPKFTKLALDGKPYPLMGDGLHTRSWMYVEDCSEAITRVALEGTLGEIYNIGTDFEMTNIELTKMIHFTVSKLLNREPTAPTFAPIPDRPYHDRRYYIDFSKIRNAMGWQCTTPFSEGLMKTIDYYVKLHVATARLQG
Protein: Elongation of very long chain fatty acids protein (EC 2.3.1.199) (Very-long-chain 3-oxoacyl-CoA synthase) (Q1RM84)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MESYEKIDKLLNSVVDSLFGERDTRVRGWLLLDSYTPTFLLTITYLLTIYLGTKYMRNRPAYSLKNVLLLYNFSVTVLSFYMLVELISAVWSAGYRLQCQALDEVGEADIRVAKVLWWYYFSKLIEFLDTIFIVLRKKNSQISFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHVLMYSYYGLATIPSMHKYLWWKRYLTQAQLVQFVLTITHTVSAWVVPCGFPLGCLKFQTFYMCTLVVLFVNFYIQTYKKR
Protein: Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) (Q00403)
Organism: Homo sapiens (Human)
Function: General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Exhibits also autoacetyltransferase activity that contributes to the activated transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:12931194}. Chromosome {ECO:0000269|PubMed:24441171}. Note=Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis (PubMed:24441171). Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle (PubMed:24441171). {ECO:0000269|PubMed:24441171}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB1
- Transcription initiation factor IIA subunit 1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIE subunit 1
- General transcription factor IIF subunit 2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Transcription initiation factor IIE subunit beta
- DNA-directed RNA polymerase II subunit RPB2
- Transcription initiation factor IIA subunit 2
- TATA-box-binding protein
Sequence:
MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKFDTPVDKLPQL
Protein: Transcription factor bHLH101 (Basic helix-loop-helix protein 101) (AtbHLH101) (bHLH 101) (Transcription factor EN 10) (bHLH transcription factor bHLH101) (Q9FYE6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor bHLH47
- Fe
- Ferric reduction oxidase 2
- Transcription factor ILR3
- Transcription factor bHLH104
- Ferric reduction oxidase 3, mitochondrial
- Transcription factor bHLH115
- Probable nicotianamine synthase 4
- Transcription factor bHLH34
- Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
Sequence:
MEYPWLQSQVHSFSPTLHFPSFLHPLDDSKSHNINLHHMSLSHSNNTNSNNNNYQEEDRGAVVLEKKLNHNASERDRRRKLNALYSSLRALLPLSDQKRKLSIPMTVARVVKYIPEQKQELQRLSRRKEELLKRISRKTHQEQLRNKAMMDSIDSSSSQRIAANWLTDTEIAVQIATSKWTSVSDMLLRLEENGLNVISVSSSVSSTARIFYTLHLQMRGDCKVRLEELINGMLLGLRQS
Protein: Protein G1 (Protein ELONGATED EMPTY GLUME) (Q8GVZ6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription regulator that acts as a developmental regulator by promoting cell growth in response to light (By similarity). Transcription regulator that restrains empty glumes growth, lemmas of the sterile florets located at the lateral side of the rice spikelet, to maintain their small size, probably by repressing lemma identity via transcription regulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:19901325, ECO:0000269|PubMed:20227044}.
Interaction partners:
Sequence:
MSSSSAAALGSDDGCSPAELRPSRYESQKRRDWQTFTQYLAAHRPPLELRRCSGAHVLEFLRYLDRFGKTRVHEPPCPSYGGRSPSAAGPVAAAAAACQCPLRQAWGSLDALVGRLRAAYDERHGRAGEPDAVAGAGAVATDSTSSSSAAAANPFAARAVRLYLRDVRDAQAMARGISYHKKKKRRGGNMNGARGGGGGGARAGVNDGDATAPPVAVTPGLPLPPLPPCLNGVPFEYCDFGSVLGGAHGAHGGHGGGGGGFYGAGVYLPFLYNTFS
Protein: Protein disulfide-isomerase 2 (PDI2) (EC 5.3.4.1) (Q54EN4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Endoplasmic reticulum oxidoreductin-1
- Calnexin
- Calreticulin
- Luminal-binding protein 1
- Luminal-binding protein 2
- Probable tetraspanin tspD
- Probable tetraspanin tspA
Sequence:
MNKFLALLFVLALFANIAFSCEGHPEHDHGDGDHEHDHDESFVKILDSDNFHNSVSEHDVTLVMFYAPWCGHCKTLKPLYEEAAKQLSANKKIAIAKVDCTQHEQLCKQNKVQGYPTLVVFKNGKAEPYEGDRTTKSIVQTLEEELKPTISTLESNEDIEEFKKQHPISVVGFFDNDHDDRFKLFSELAGNNKKSAKFAVVIDKDFSKEHVESTPNVVLFRSFDEPTVAHKGEFDSESLIKFIKGNSVPLLGEINRNTYKKYESIAVPLAYLFIDSTQDNTQVLEDVKKIATSQKGNAVFCWVDMKKFPQQATHMGLSGKVVPAISVDSVANKARYNFDEKETFSFDTVSKWIQDVIGGKVSPFVKSQPEPESNDAPVKVAVGTTFKKLVLDSPKDVLVEFYAPWCGHCKNLAPIYDKLGEYLKDVESVSIVKIDADSNDVPSDIEIRGYPTIMLFKADDKENPISYEGQRNDHMNFVEFIQDNAAIEFKLPSSQTDDNVESKKDSSAKHDEL
Protein: Mitochondrial import inner membrane translocase subunit TIM44 (Q8IHE3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273, ECO:0000256|PIRNR:PIRNR037871}.
Interaction partners:
Sequence:
MKATSCRPIPFINFRIVRYFYRPRRLNKYYDIYRIAALVRDRACLFTCQQASQNLQQQQPRFYSAPGRRAGFFSQFFDNMKAEMDKNKEIKDNIRKFREEAQKLEESDALKSARQKFNIVESEAQKSSSMLKEQLGAIKERVGDVLEDASKSHLAKKVTEELSKKARGVSDTISDTSGKLGQTSAFQAISNTTTTIKKEMDSASIENRVYRAPAKLRKRVQLVMSDSDRVVEPNTEATGMELHKDSKFYESWENFKNNNTYVNKVLDWKVKYDESENPVIRASRLLTDKVSDVMGGLFSKTELSETMTELVKIDPSFDQKDFLRDCETDIIPNILESIVRGDLEILKDWCFESTFNIIANPIKEAKKAGLYLDSKILDIENIELAMGKVMEQGPVLIITFQAQQIMCVRDQKSQVVEGDPEKVMRVHYVWVLCRDRNELNPKAAWRLMELSANSSEQFV
Protein: Proto-oncogene c-Rel (P15307)
Organism: Mus musculus (Mouse)
Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- NF-kappa-B inhibitor alpha
- Nuclear factor NF-kappa-B p105 subunit
- NF-kappa-B inhibitor beta
- Transcription factor p65
- NF-kappa-B inhibitor epsilon
- Nuclear factor NF-kappa-B p100 subunit
- Transcription factor RelB
- Targeting protein for Xklp2
- Tumor necrosis factor receptor superfamily member 5
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
Sequence:
MASSGYNPYVEIIEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSVQIMNYYGKGKIRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGPERRPLFFQNLGIRCVKKKEVKGAIILRISAGINPFNVGEQQLLDIEDCDLNVVRCVFMFFLPDEDGNFTTALPPIVSNPIYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEARGVFSQADVHRQVAIVFKTPPYCKAILEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDAYGNKSKKQKTTLIFQKLLQDCGHFTEKPRTAPLGSTGEGRFIKKESNLFSHGTVLPEMPRSSGVPGQAEPYYSSCGSISSGLPHHPPAIPSVAHQPTSWPPVTHPTSHPVSTNTLSTFSAGTLSSNSQGILPFLEGPGVSDLSASNSCLYNPDDLARMETPSMSPTDLYSISDVNMLSTRPLSVMAPSTDGMGDTDNPRLVSINLENPSCNARLGPRDLRQLHQMSPASLSAGTSSSSVFVSQSDAFDRSNFSCVDNGLMNEPGLSDDANNPTFVQSSHYSVNTLQSEQLSDPFTYGFFKI
Protein: cDNA FLJ11939 fis, clone HEMBB1000592 (Q9HAA0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGLISHLERLMAEGKWGGTGVVEGMGMAEEGAGNGKAVWGMGRGKGERSPSLSSTFPQGRRSQVPGLGSGHPCSGRLDPKSQTPEAPGSGCVLSTCPGPLLSSLSGQPPQPPSLNSRGSIAPGHPSPAPALPFPQRWPLHLCSDLSPSLCPSFSHKCHEFSNIFGSQPAAAMNFVGLRGRGSRKELGGRGQVGGWRDPFCC
Protein: ABC transporter protein (P-glycoprotein) (O93437)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MHSEDEKQKHTVDGNTYEIANSNQDQDPEDEKKGKKKKGKKPQMVSPLALFRYSSCTDKLLMIFGSLLAIAHGTSLPIAMIIFGDMTDSFVTSGMTNITGNSSGLNSSADVFNKLEEEMTRYAYYYSAIAAAVLVAAYIQTSFWTLAAGRQVKKIREKFFHAIMRQEIGWFDVNDAGELNTRLIDDVSKINEGIGDKIGFLIQSETTFLTGFIVGFIRGWKLTLVILAVSPVLGLSAALWAKILTAFTDKEQAAYAKAGAVAEEVLSAVRTVIAFGGQEKEIKRYHKNLEDAKRIGIRKAITSNISMGAAFLLIYASYALAFWYGTTLILANEYSIGNVLTVFFSVLIGAFSIGQTAPSIEAFANARGAAYAIFNIIDNEPEIDSYSDAGHKPDHIKGNLEFQNVFFNYPSRPDVEILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDPKEGTITIDGQDLKSLNVRYLREIIGVVNQEPVLFATTIAENIRYGREDVTMEEIERATKEANAYDFIMKLPKKFETVVGERGAQMSGGQKQRIAIARALVHNPKILLLDEATSALDTESESVVQAALDKAREGRTTVVVAHRLSTVRNADLIAVFESGVITEQGNHSQLIEKKGIYYKLVNMQTIETEDPSSEKSENAVSVKRSGSQSNLDESLKKELRRGSTRRSMKKPGEPNDTDEKGSSPDEELPPVSFLKLMKLNKNEWPYFVAGTFCAIVNGALQPAFSVIFSEIIGIFSETDQKVLREKSNLYSLLFLALGIISFFTFFVQGFAFGKAGEILTMKLRFMAFKAMLRQDMAWFDDPKNSTGALTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAVVPIIAVAGMIEMKMLAGHAKKDKIELEAAGKIATEAIENIRTVASLTREKRFELMYGEHLLVPYRNSVKKAHIFGFCFSLSQAMMFFTYAGCFRFGAYLVVNGHIEYKTVFLVFSAVVFGAMALGQTSSFAPDYAKAKISAAHLFVLFNRVPPIDSYREDGEKPEKFGGNTRIKDVKFNYPNRPEVKILQGLNLAVEKGETLALVGSSGCGKSTVVQLLERFYDPLSGEIVFDDIDAKTLNIQWLRSHIGIVSQEPILFDFTIAENIAYGDNSREVSHEEIISAAKAASIHSFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALIRKPQILLLDEATSALDTESEKIVQEALDKAREGRTCIVIAHRLSTIQNADKIAVIQNGKVIEQGTHQQLLAEKGFYYSLVNVQSGSCNM
Protein: Small ribosomal subunit protein uS10c (30S ribosomal protein S10, chloroplastic) (Q9LK61)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000250}.
Interaction partners:
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein uS9c
- Large ribosomal subunit protein bL28c
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS14c
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL38z/eL38y
- Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein
- Large ribosomal subunit protein eL42z/eL42y
Sequence:
MAVSTVSSFLLPSFGIPSSSPSSTRLKVSLLPSSSTHGGLSSCVLTKPSVSLTKVFAVPDTLDPTPEILDEPASEVPSSSSISVDADKMAPKQKIRIKLRSYWVPLIEDSCKQILDAARNTNAKTMGPVPLPTKKRIYCVLKSPHVHKDARFHFEIRTHQRMIDILYPTAQTIDSLMQLDLPAGVDVEVKL
Protein: Trihelix transcription factor GTL2 (GT2-LIKE protein 2) (AtGTL2) (Trihelix DNA-binding protein GTL2) (Q8H181)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that binds specific DNA sequence.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Alcohol dehydrogenase transcription factor Myb/SANT-like family protein
- UMP kinase
- Trihelix transcription factor ASIL1
- At5g63780
- 14.7 kDa heat shock protein
- Trihelix transcription factor GT-3a
- Xyloglucan 6-xylosyltransferase 2
- Trihelix transcription factor GT-3b
- Trihelix transcription factor ASIL2
Sequence:
MFDGGVPEQIHRFIASPPPPPPLPPHQPAAERSLPFPVSFSSFNTNHQPQHMLSLDSRKIIHHHHHHHHHDIKDGGATTGEWIGQTDHDDSDNHHQHHHHHPWCSDEVLALLRFRSTVENWFPEFTWEHTSRKLAEVGFKRSPQECKEKFEEEERRYFNSNNNNNNNTNDHQHIGNYNNKGNNYRIFSEVEEFYHHGHDNEHVSSEVGDNQNKRTNLVEGKGNVGETVQDLMAEDKLRDQDQGQVEEASMENQRNSIEVGKVGNVEDDAKSSSSSSLMMIMKEKKRKKRKKEKERFGVLKGFCEGLVRNMIAQQEEMHKKLLEDMVKKEEEKIAREEAWKKQEIERVNKEVEIRAQEQAMASDRNTNIIKFISKFTDHDLDVVQNPTSPSQDSSSLALRKTQGRRKFQTSSSLLPQTLTPHNLLTIDKSLEPFSTKTLKPKNQNPKPPKSDDKSDLGKRWPKDEVLALINIRRSISNMNDDDHKDENSLSTSSKAVPLWERISKKMLEIGYKRSAKRCKEKWENINKYFRKTKDVNKKRPLDSRTCPYFHQLTALYSQPPTGTTATTATTATSARDLDTRPEENRVGSQDPDISVPMHVDGDGAGDKSNVQFSGFDLEF
Protein: Protein SHORTAGE IN CHIASMATA 1 homolog (OsSHOC1) (B9F1C0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Essential for normal crossover (CO) formation during meiosis. Essential component for the formation of class I meiotic COs. Interacts with PTD, another meiotic component, to regulate CO formation, possibly by stabilizing the recombination intermediates during meiosis. SHOC1 and PTD may form transient heterotrimeric or heterotetrametric complexes with HEI10 and/or ZIP4 to promote class I COs formation. Does not seem to be involved in early meiotic recombination steps involving double-strand break (DSB) formation, processing, and single-strand invasion. Does not seem to be involved in homologous pairing or synaptonemal complex (SC) assembly.
Subcellular location: Chromosome {ECO:0000269|PubMed:31266799}. Nucleus {ECO:0000269|PubMed:30589140, ECO:0000269|PubMed:31266799}. Cytoplasm {ECO:0000269|PubMed:30589140}. Cell membrane {ECO:0000269|PubMed:30589140}. Note=Predominantly localized in the nucleus (PubMed:30589140). Localized in punctuate foci onto meiocyte chromosomes from leptotene to early pachytene with a maximal number of foci at zygotene (PubMed:31266799). {ECO:0000269|PubMed:30589140, ECO:0000269|PubMed:31266799}.
Interaction partners:
- Nitrate reductase 1
- Nitrate reductase
- Nitrate reductase
- E3 ubiquitin-protein ligase CCNB1IP1 homolog
- DNA mismatch repair protein MSH5
Sequence:
MRTRFLATDYFAPSSSSAAGKALALEFFSFPSLPVPALPPDPHFLPFTSADELPAATVADDGLGPLPIASALSDFLAAVIPQALPVPTVPAADEVLDDFLYDRGGYGEDFSSWEFGAFRIPKASEGYGVINREKDEKGEGSRSDGLEISSVMKRWEQLKELRFEVVEVDLLMALQEDIASFGEEESGGGVTLLLRVPDMKIHLDFIDIETDIKIRYQSDLPESVYQVEKVPVKDNDGNGHSSLREDCCLEIAALDHGAVIPRLEVSRNSWELDDCLTETDRYGVFDNVVRHLDEAQIQHSVFKSTEFLRSTDMDMLTFVCEDAPCHDIQVDKPAEIKAAVEMDVVRINGNILLEKNSALYPLKPDGTCSDLPCSILLEEVQIIDFPSDNVFKMLVQSETNKMNISDEIFKDDFDPARRLYESMVSCELALVDDTFRSLPTPILNDDIAVRSRVPPIQEILCSLKPHPLSASDGIYLDWHLLLEGPCNREICCSYASMVEEAKTCHLSSELQRSCQSTSVFVSDFLEDFQRSPKLQDEDKHSDIYVPAPLSHDPQKLEATQKCEQEGGTRNHSSMKRPSPEKSSSFPELISHSGDLNFYLNVRSATKSGTNNENTSTLDVPHSEEQALSLSTRAKVDKLIEIHPVSPSNLIQGLIEQIHASYTSALQESTYWRHSFSDEQGLGISKQKLLELITGEGSEGSYNHCEHKDKMELIVLYALKQVAYYLCFFGLHAAHLYISNLTRSLENTPERLKHILWSISEAQRKSERQLFESHPSLSCIETILRSNKQIDQKILIVADRAFWLPLGQKLASMRMTFVEFGQNPATTFVDLVNKTNSTAWVLEELLKSDCILLDNKNIPASFPFDKFGIILEYGGPNKSSTLLSLAPKLDGLPPLHFLYVKVDGKDFPAALVEDNHKDQDLKSTLDKVLLTLQKDLQERMNKMRIVDSLNFIPATNQLQGLQEKRSKHFAADATKELLPDDQPHRLQNLNKKNTFDSHNVVLADEQLHIQQTLSNKPVVNSQCVPTVEKSSSTSSVSANVLKDPQENQSTTDLPSCVKNDCIMPGRLSVPDVVIVVNTGNHGKTMLVSRRSSYQQILALEKGGMQVVERDIDLPVDLILSAAVCLVWYETALFEANELTTSAETSGIKENVENIATNILMSVSFSFTGCIMVFEGEADFLSAVMDSSDSLYTAAASLDMNLQLFFSHTPRSTDEIILNCITNVTSCYKAPLPDIPESESLAESFLTSFPSINPVSAYMLLSSGGSLVEFLSWPHERRIQAVGKYLLSPKIISLFNALCKFGELGESRSVMTECSSVDSDISSAFLQSPRKRKQRSLQACAVPTNKLLFSDSLNQIPGDYAEHAEVFSPSKLRKFSDMDNTIPELPDVFTFDESLNMRSEGFSYQQKKHDVDAIPGNQVINDDFSNGLTPNNQAYNRRTGNMVDTFDLPWQPEFGGTHPSKSTFHTSRPSCSRTHSNPVFSTAFEINDDPGEWNISGGTKQTWKGLAHGGTVDDSYRYDMDNRYHEPRDEIMQHPASSLAFQKLDFGSHATSQGSCWEIDYLRQMSAKRKARQERSRCSNSPGMSIPRMRDSNSKILNPPPKESFRYRGDRDTPSRDQSPSIGTQHYGKGKEGAKAQNRRARKDFNVQPTSHKKRIEPSIDPTWTPIDKRARQKLSFVTYGKEKQSKLVWRNQNSPGVGCGFRKRFREEGT
Protein: Transcriptional activator (DUF662) (Q8L9S7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Carboxylesterase SOBER1
Sequence:
MTTTNEATTQPPQQMMSLSFSSQMSKEDEEMARSALSAFRAKEDEIEKRKMEVRERVKAQLGRVEEETRRLASIREELETMADPMRKEVNWVRKKIDSVNKELKPLGSTVQKKEREYKEALDTFNEKNREKVQLITKLMEMGQLVGESEKLRLKKLDELSRSIDTESESISQDKTIPIKN
Protein: Putative hydroxypyruvate isomerase (EC 5.3.1.22) (G4XUV3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGLGAVPGRQAAFREGLEQAVRYAKALGCPRIHLMAGRVPQGADRIAVKAEMEAVFLENLRHAAGVLAQEDLVGLLEPINTRITDPQYFLDTPQQAAAILQKVGRPNLQLQMDIFHWQIMDGNLTGNIRGFLPIVGHVQVAQVPGRGEPSSPGELNFPYLFQLLEDEGYKGFVGCEYQPRGDTVEGLSWLRSYWDRRATQRLASEGPHTTHVPPDSE
Protein: X antigen family member 3 (XAGE-3) (Cancer/testis antigen 12.3) (CT12.3) (G antigen family D member 4) (Placenta-specific gene 6 protein) (Q8WTP9)
Organism: Homo sapiens (Human)
Interaction partners:
- X antigen family member 1
Sequence:
MIWRGRSTYRPRPRRSVPPPELIGPMLEPGDEEPQQEEPPTESRDPAPGQEREEDQGAAETQVPDLEADLQELSQSKTGGECGNGPDDQGKILPKSEQFKMPEGGDRQPQV
Protein: Protein PAT1 homolog 1 (Q20374)
Organism: Caenorhabditis elegans
Function: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity). Required for the recruitment of P-body components such as cgh-1 in somatic blastomeres. May play a role in recruiting the decapping enzyme dcap-1 to cytoplasmic puncta in the cell body of the posterior touch receptor neuron, PLM.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:18692039, ECO:0000269|PubMed:18695045}.
Interaction partners:
- U6 snRNA-associated Sm-like protein LSm1
- ATP-dependent RNA helicase cgh-1
- CCR4-NOT transcription complex subunit 7
- m7GpppN-mRNA hydrolase dcap-2
- U6 snRNA-associated Sm-like protein LSm7
- mRNA-decapping enzyme 1
- U6 snRNA-associated Sm-like protein LSm3
- U6 snRNA-associated Sm-like protein LSm2
- poly
- 5'-3' exoribonuclease 1
Sequence:
MEEVKKYGKTLEEIEGGLMFDDFPESLVDSDEDHNIFDDEFDAANDETFGGGLDNIGENAELENYATQTAKLRFDDPVWQKPSSSDHVAPSASEIPIPFPNFGNGDASDSFKSSFEAESPFLKKSIWGNGTDGAYNIWGTNFGISSVPAAPTLDLDFGALLPTPTIQATKEVKSSQIPSMPSSALTLEDCERMQMGNKPDSLVDAFKDLQLGSTPVQPQSAQFSKHPLEARIAAPGTPATASSQALPTLPTAALSLEELELQIMKEAQILKGRQQVPSDMREDNKFSHPPPGFNQNVQPRMDPSLSPGGMHGMPPSMGTSMPHMGPMMPPQNMQLPRLPPLNPQFLPLIPVWFNAIINNIQLPMGVPPPPPFLFQLLNHYRNPQLVHAMIMQSSIPPNIRQNGPQFSHPSGPHSPGNRVQRKHSGMPSTRTIYDLALDSFAGYMSYKEREWLIRIQFIQCKGSGDPQVDDYYYVTWRDKQIANGWTAETKLEEATKEKKEKSSESQKDYLERISRMNYREMQKERARERDKERQRERQERIDRGEDKKLRQTLSDKFATSLGLPSKSSTHNPRHVLDMKAQVESVDNQTKKLSDEERKIAVAKKLRTMLLRLEGALNILMEVDELRRSSLPEKSQFKDLSSDEKDQEVEKRTTVIINELMGDDLSKLMQMSKGRAVITRTLKVVEPRDQARIILALMTAGGLVSKKMYGEIVLDILPVVYQKVSNLHPDQFKYLVGALNLDTLKRQLLDSNMFIRDMMMTLFFVSVKNNQQLVEWAKATKFSSLKMPSSAPLSIWRKALSVISDSEIKEFADDIKYSGIVDCHDVAQLIEQSL
Protein: Rap guanine nucleotide exchange factor 1 (F1M8L9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Crk-like protein
- Adapter molecule crk
- E3 ubiquitin-protein ligase CBL
- Breast cancer anti-estrogen resistance protein 1
- Growth factor receptor-bound protein 2
- Fibroblast growth factor receptor substrate 2.
- Ras-related protein Rap-1b
- Guanine nucleotide exchange factor MSS4
- Ras-related protein Rap-1A
- Paxillin
Sequence:
MGNAIEKQKPLRQSHLCPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKTPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVDSRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTEREMEILNKTSVSPSTELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRAVSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQTPPQAACNLSPLPESMGESGPPFVGYSFQLPLGSCLQQDGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEDDLQNPAQPVSYPPFAAILPFQQGASSTPVEFVGDFSVPESAGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSDSFCGSDSTQELAPPPALPPKQRQLASYAASSFSVSHCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSYKSVFRSYSQDFMPHHQASVQPFLPPTSSSSPHFPPVHASQSSDLAVPTVSSPPPSTVDGPLSSSQDSSFHGNPVRLPSETSFTDSSENASSEEAGGGEYVNLYSSGQTSEELAPSGGEPPSGKDGHPRDLSVSSASGKDSRENGERSPKSLDALESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQCRYPSPPKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSVIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQVHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
Protein: Solute carrier organic anion transporter family member 3A1 (Organic anion-transporting polypeptide D) (OATP-D) (Prostaglandin transporter subtype 2) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11) (Q99N02)
Organism: Rattus norvegicus (Rat)
Function: Mediates the Na(+)-independent transport of organic anions such as prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin. Also displays a low transport activity of estrone 3-sulfate. Shows a pH-sensitive substrate specificity towards T4 and estrone 3-sulfate which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier.
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9UIG8}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9UIG8}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000250|UniProtKB:Q9UIG8}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Vasopressin-neurophysin 2-copeptin
Sequence:
MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCATNGSSSDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPGMESEQAMLPEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTVPVAGVTVRYGNNSARGSPLDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPPENATVVPGKCPSPGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTSEFLASTLTLDNLGRDPVPAHQTHRTKFIYNLEDHEWCENMESVL