wanglab/gogpt-training-data huggingface dataset:
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q288P2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MRVRILNRTSVLSLGLCSLLLLSAVAAAQSEERERECAFNDQHQQVDEQSVAGDWHITRENNTILCSKSSRCYGLWEKTHDGEIRLVKQGCWTYIGDQQDCHDDRCVVTTTPSQIQNGTYRFCCCSTNMCNVNFTENWVPSPTSTANRDQPPIHRDEAIFIALASVSIVAVLIVALFFGYRVMMGECKQGLHNMDMIEAAPSEPSLDLDSLKLLELIGRGRYGSVYKGSLDERPVAVKVFTYANRQNFVNERSIYRVPLLEHENIARFIVGDERMTTDGRMEYLLVMEYYPHGSLCRYLSLHTLDWVSCCRLAHSLTRGLAYLHTELLRGDIYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMKLTGNRLVRPGEEENAAISEVGTIRYMAPEVLEGAVNLRGCESALKQVDMYAIGLIYWETFMRCTDLFPGETVPEYQMAFQAEAGNHPSFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETMEDCWDQDAEARLTAQCAEERMAELLLIWERNKPVSPTINPMSTALQNERNLTHSRRAPKMGSYPDYSSSSYIEDHEGMVKNLPGDVSTSGTSSVGGVGVSGSSGGVAATGEKNRNSINYERQQAQAQARLPSPETSGTSLSTTTTTTGLTPSTIMTTISESGHSEDTGAGGSVPVCLQLTEEDLETTKLDPKEVDKNLKESSDENLMEHSQKQFSAPDPLSSGSTSLLYPLIKLAAEVTGGSGSGGQTDFGVGSSGMSDTPTAMFPLPKQQNLPKRPTSLPLNTKNPGRESSSSRLKFGKHKSNLKQVETGVAKMNTVVAVEPHLATVTNNGPSVRSGAGVVVVNGYGVGNGASSSDAFGNTNPVGPQGEGGAPLLQSQLSGEDSRLNININSSPDEHEPLLRREQPAARDHSGRTNSNNNNSNIHTTATFCALTAADAQIEALTCLSGAPDGRDNGVPLRPPKPRRPERPNSLDLSASSQDSSLLGEAVSQEGKAGSAEKIKKRVKTPYSLKRWRPSTWVVSTDTLDGEVNNNGHSQQTTMAVSGGGHPSAGQSKSSIAVFLVGGGTATATLTSDPPDMTCL
Protein: Large ribosomal subunit protein mL55 (39S ribosomal protein L55, mitochondrial) (L55mt) (MRP-L55) (Mitochondrial large ribosomal subunit protein bL31m) (Q7Z7F7)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Interaction partners:
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein mL52
- Large ribosomal subunit protein mL65
- Large ribosomal subunit protein mL41
- Mitochondrial ribosomal protein L40
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein mL51
- Large ribosomal subunit protein mL39
- Large ribosomal subunit protein mL37
- Large ribosomal subunit protein uL13m
Sequence:
MAAVGSLLGRLRQSTVKATGPALRRLHTSSWRADSSRASLTRVHRQAYARLYPVLLVKQDGSTIHIRYREPRRMLAMPIDLDTLSPEERRARLRKREAQLQSRKEYEQELSDDLHVERYRQFWTRTKK
Protein: Cyclin-dependent kinase 5 activator (F1Q6W4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Cell projection, neuron projection {ECO:0000256|ARBA:ARBA00004487}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Perikaryon {ECO:0000256|ARBA:ARBA00004484}.
Interaction partners:
- Cell division protein kinase 5
- Cellular tumor antigen p53
Sequence:
MGTVLSLSPSYRKAALFEDGPATVGHYTAVQNSKNAKDKNLKRHPLINVLPWKRIVAVSAKKKGSKKVQPNTTYQNNVSHLNNENLKKSQSCANLASFTQDQTSPSNQGSKNSNNTASSVKKAPLSNSNAVPGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFVYMLCRDVVSSEVATEHELQAVLLTCLYLSYSYMGNEISYPLKPFLVETSKETFWDRCLSIINLMSAKMLQINSDPHYFTQVFADLKNESQKEEERSRLLIGLDR
Protein: Spermine synthase, isoform D (EC 2.5.1.22) (X2JGL7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Arginase
- Deoxyhypusine hydroxylase
- S-methyl-5'-thioadenosine phosphorylase
- Eukaryotic translation initiation factor 5A
Sequence:
MAAQTILFDFTLDKDKTADEEARLQVAKILRNELEQLFPQLELAYSMESPENGYFAVLHENKDTVITCRIFQHGLLTLNVEYFLPDGKEPSISFDTMRTMELILRQKFDSDRSKYLPPIKRGGYIDIYMTSSDERIIEYDIDKVVFEARSPFQKIQIMHSKTLGNMLLLDELQNIAESDLIYTETLMCRGVENYEGKEICILGGGDGALLYELLKENPKHVVMLEIDELVMQTCNKYLNVICGDVLEKRKGDQYEIIVGDCVEYLKKFIAEGRKFDYVFGDLTDIPITDAPEGETWDFIRTIFEHSFKVLKPDGKYLTHGNGSTCKVQLRLFEEQLNLLRPKVKFTTTKAFVPSFMEEWLFYQVTFAXQAQVDSSAAAVATSSAPPTASHTPASHSISQEPGTVGEMLQLHSYTVTIHGAAVGVQEEENMNNGAVGQLKPRPRRRKKKRVHYHHTLVS
Protein: Zinc finger protein RME1 (P32338)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the control of meiosis. Represses the transcription of the IME1 gene thereby inhibiting cells from entering meiosis. But also activates the CLN2 gene thus promoting mitosis.
Subcellular location: Nucleus.
Interaction partners:
- Regulatory protein SWI4
- G1/S-specific cyclin CLN3
- Regulatory protein SWI6
- Protein BCK2
- G1/S-specific cyclin CLN2
- Meiosis-inducing protein 1
- Silenced mating-type protein ALPHA2
- Silenced mating-type protein A1
- Glucoamylase, intracellular sporulation-specific
- Respiration factor 1
Sequence:
MSPCYGQNSAIAKGSWNREVLQEVQPIYHWHDFGQNMKEYSASPLEGDSSLPSSLPSSTEDCLLLSLENTITVIAGNQRQAYDSTSSTEEGTAPQLRPDEIADSTHCITSLVDPEFRDLINYGRQKGANPVFIESNTTEQSHSQCILGYPQKSHVAQLYHDPKVLSTISEGQTKRGSYHCSHCSEKFATLVEFAAHLDEFNLERPCKCPIEQCPWKILGFQQATGLRRHCASQHIGELDIEMEKSLNLKVEKYPGLNCPFPICQKTFRRKDAYKRHVAMVHNNADSRFNKRLKKILNNTK
Protein: Protein TRANSPARENT TESTA 1 (TTL1) (WIP-domain protein 1) (Zinc finger protein TT1) (Q8VWG3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a transcriptional regulator involved in the differentiation of young endothelium. Altered differentiation results in incompetence for pigments synthesis and the lack of condensed tannins in the seed coat. Plays a role in the regulatory network controlling flavonoid accumulation in endothelium cells during seed development.
Subcellular location: Nucleus {ECO:0000269|PubMed:11782451, ECO:0000269|PubMed:20541552, ECO:0000269|PubMed:21477081}.
Interaction partners:
- Transcription factor TT2
- Transcription factor TT8
- Protein TRANSPARENT TESTA GLABRA 1
- Protein TRANSPARENT TESTA 16
- WRKY transcription factor 44
- Protein DETOXIFICATION 41
- Chalcone--flavanone isomerase 1
- Laccase-15
- Glutathione S-transferase F12
- Dihydroflavonol 4-reductase
Sequence:
MESPPLYEISSSSSSEKPRHHFQSLDLFPNLNQNSCINNTLIEPLPLIDRINLNSNLDLNPNPLYAEEGEQEEEEEEEEDREVDVDLHIGLPGFGKPSNDAKQLKKRNGKEIATYDAGKGIENELSGKAYWIPAPEQILIGFTHFSCHVCFKTFNRYNNLQMHMWGHGSQYRKGPESLKGTQPRAMLGIPCYCCVEGCRNHIDHPRSKPLKDFRTLQTHYKRKHGHKPFSCRLCGKLLAVKGDWRTHEKNCGKRWVCVCGSDFKHKRSLKDHVKAFGSGHGPYPTGLFEEQASNSSVSETLFF
Protein: Major capsid protein (Q858G8)
Organism: Salmonella phage epsilon15
Interaction partners:
Sequence:
MALIGQTLPSLLDIYNRTDKNGRIARIVEQLAKTNDILTDAIYVPCNDGSKHKTTIRAGIPEPVWRRYNQGVQPTKTQTVPVTDTTGMLYDLGFVDKALADRSNNAAAFRVSENMGKLQGFNNKVARYSIYGNTDAEPEAFMGLAPRFNTLSTSKAASAENVFSAGGSGSTNTSIWFMSWGENTAHMIYPEGMVAGFQHEDLGDDLVSDGNGGQFRAYRDEFKWDIGLSVRDWRSISRICNIDVTTLTKDASTGADLISMMVDAYYARDVAMLGDGKEVIYANKTIHAWLHKQAMNAKNVNLTIEEYGGKKIVSFLGIPIRRVDAILNTESAVTA
Protein: Photosystem II reaction center protein J (PSII-J) (Q2LIL6)
Organism: Oryza glumipatula
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01305}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01305}.
Interaction partners:
Sequence:
MADTTGRIPLWLIGTVTGIAVIGLIGVFFYGSYSGLGSSL
Protein: SPRY domain-containing SOCS box protein 1 (SSB-1) (Q9D5L7)
Organism: Mus musculus (Mouse)
Function: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links the NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96BD6}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000250|UniProtKB:Q96BD6}.
Interaction partners:
- Elongin-C
- Cullin-5
Sequence:
MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGKERLGAIPALPLPASLKAYLLYQ
Protein: Uncharacterized protein (Q869Q6)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Fructose-bisphosphate aldolase
Sequence:
MNIIKLLLVLICFIGIISAQTFNFAFDPTLCGAQENPCRFTDPTNWQQGAVPSNNSNVVIDFTKVTNANKQVFIVASGINNIFTSINIVGTSAVNVVVSFQNTNMQVTGGFTGNNSATIVFDNEKSNNITQFGYDVEVNGKFLLFGSTMQASYSILQFKDIFTDQNSQFSAQSFSNVLINGVAQFWTTVTFTDNSILTANECFFNAGINSDDRVIVGPTTFYGQSNLEIVTLNDDIIVQGGALTIADSFKYTGNPSIKVTNANLTISGSASANFPSINLQNANLICFHPKGNFANGVQGNGQITFDINKQGNVESECYLWNVNSVGISVTVAGGLNLFVQNCTFGHLTDKQSSFVINPDHQPTPSVQFDGGNSLGYISTNLTQIVFSDASMNTLNGPFDSWVRKYPINLLGNLAFNQVNFFGSIDTLDKDSYIGIDSGIIGGSVDLIAGRIHPQSIATINGDLIMTSGAVLDMDQTSEQFAVAGNLEMDAESTIFIAETLSTDAGALITVDGNLVLNGTLIMDITDTNPSDGDSYKIISCAGSTLGTFSTIVPLTNGQATTLDYSVSVSDDGIVSIKFNSKEQSHKKLPGWAVFLIIVAVLGTVAGGAYGYIRYKKRAGYLPINN
Protein: Heat shock protein family B (small) member 7 (D3YTC6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSHRTSSTFRAERSFHSSSSSSSSSTSSSASRALPAQDPPMEKALSMFSDDFGSFMRPHSEPLAFPARPGGAGNIKTLGDAYEFAVDVRDFSPEDIIVTTSNNHIELAADGTVMNTFAHKCQLPEDVDPTSVTSALREDGSLTIRARRHPHTEHVQQTFRTEIKI
Protein: Glucans biosynthesis protein C (EC 2.1.-.-) (P75920)
Organism: Escherichia coli (strain K12)
Function: Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Phosphoglycerol transferase I
- Glucans biosynthesis protein G
- Glucans biosynthesis glucosyltransferase H
- Phosphotransferase RcsD
- O-acetyltransferase WecH
- Iron
- Protein AmpE
- Uncharacterized protein YpfG
Sequence:
MNPVPAQREYFLDSIRAWLMLLGIPFHISLIYSSHTWHVNSAESSLWLTLFNDFIHSFRMQVFFVISGYFSYMLFLRYPLKKWWKVRVERVGIPMLTAIPLLTLPQFIMLQYVKGKAESWPGLSLYDKYNTLAWELISHLWFLLVLVVMTTLCVWIFKRIRNNLENSDKTNKKFSMVKLSVIFLCLGIGYAVIRRTIFIVYPPILSNGMFNFIVMQTLFYLPFFILGALAFIFPHLKALFTTPSRGCTLAAALAFVAYLLNQRYGSGDAWMYETESVITMVLGLWMVNVVFSFGHRLLNFQSARVTYFVNASLFIYLVHHPLTLFFGAYITPHITSNWLGFLCGLIFVVGIAIILYEIHLRIPLLKFLFSGKPVVKRENDKAPAR
Protein: A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) (Q9P0M2)
Organism: Homo sapiens (Human)
Function: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:10613906}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit gamma
- cAMP-dependent protein kinase type II-beta regulatory subunit
- A-kinase anchor protein 1, mitochondrial
- Voltage-dependent L-type calcium channel subunit alpha-1C
- 3',5'-cyclic-AMP phosphodiesterase 4D
- A-kinase anchor protein 5
- Endoribonuclease YbeY
Sequence:
MERPEAGGINSNECENVSRKKKMSEEFEANTMDSLVDMPFATVDIQDDCGITDEPQINLKRSQENEWVKSDQVKKRKKKRKDYQPNYFLSIPITNKEIIKGIKILQNAIIQQDERLAKAMVSDGSFHITLLVMQLLNEDEVNIGIDALLELKPFIEELLQGKHLTLPFQGIGTFGNQVGFVKLAEGDHVNSLLEIAETANRTFQEKGILVGESRSFKPHLTFMKLSKSPWLRKNGVKKIDPDLYEKFISHRFGEEILYRIDLCSMLKKKQSNGYYHCESSIVIGEKNGGEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGEGSSVKTEAADQNGNDNENNRK
Protein: Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (Q388Y3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSVYGNGGDHEWTPSFSPPLYVQRAQKVQTLLRENGCSSFIDAGCSSGGLLRHILTSQLQEHSFSRALAIDLDKVALHEAKEAITALGFSSPVALLHPMHVEFVQGDLTKPPVFTPFEEDKEREREIGKEATQLGEAVPRTQLSHQYDAVISIEVLEHINVSDVPLFTEVLFAHLAAACGARVVVITTPNRDRNGIGNAKSNVTGQLGGSIQPRLNGAPHSLPGLPYNVRHEDHKFEMTAAQFRRYCDYVIEAYHPRWVSYTLFGVGEMFTQGSIFHAGPDRVAVRRQKVLPSLPVTLDALKETRFPLSQLSGVPPLTPSDAGGSEINWTHDMLARGRLFPWEEVFGELSTRPDEDMLCCIRTTSPYCSLPPVEMPYKPLWNRMGEAVRGAFAAAASEDEVVQEHDSYLSFADVSVNYHYRFFAPFNASLCALISCMLRKVHRRNGIWNPNDRPARPLVRCSESASGYVRLVLAWILYDCWGVDALKRGVGDDSYGSARRTLSSDEMKVLLFLSSLGFFPGSVHHLRSVLHRGRLLTGSGRRRGVGGNRRAASATSGCSSEIDKANREKIRWLSYALFQHGVSARHIASCWNNVA
Protein: Neuroligin 1 (B9VMQ4)
Organism: Apis mellifera (Honeybee)
Interaction partners:
Sequence:
MSRMLRLELVGLVLLACTQILTEHRNIYETRPVYGYRSKFLDPPERFTREVRVKQGRLRGIVVQPRTNHDLQPVDVFLGVPYAEPPVNFLRFSPPRSPEPWRGTRESQEFAPVCPQVVPKLQDEMKPVRYEYLERLLPYLKNQSEDCLYLNIYTPHQPEGQKTLRKYPVMVFIHGESFEWNSGNPYDGTILAAYGNVVFVTISFRLGILGFLRPGIRDDTASNFGLLDQIAALLWLRENIAEFGGDPNSITLVGHGTGAIFANLLLISPVANKKGLFRRAILMSGSALSADAIGKAPLQITKQVAHALHCPTTTDSDLAICLRGQDVDTLLNVKIHKPSYVPAFAPLIDNAVIPDKPYNLMKNPQMFDRFDQMYGVTESEKYHLLSPVDLMHGMSEGQRDAVLKEHAKATHELEAELILSKILEQYGDFSPGFQGEYMLKNRDLVLEALSDSGTAAPLIMAANLHSRANPNSYMYVFAHPKATQEYSGQQRKYTVHSEELPYLLGAPLDGLRGRYDIGGTLFSEAIMNWWCSFAYIGNPNVKAISKRYPYMRNGLKELSQYDIDWPEYDPQNQRYLNLTIPPSTGMQYRLAEMQFWSEHLPKMLLHPGKDIPLPIRPKGPRPQIPDIADGIGKYAYASRDYDTYGSRFKEGSRSGAEAGITAEERSTTSEIATSPQSLEEEAIAQPSAPKSSSVIAMLTGFGALFLLINFTACLYLYCKKQETKMKGAGVKRRASQKEAESDRYENHYGELGYKSDSKPDLNDVIKNDKAYDNNSNFGRRSKLSRQSSGSTIDTHIKVREWIQQEIVHR
Protein: Anoctamin (A0A8I6GL36)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU280814}.
Interaction partners:
Sequence:
MQDTQDSDISLEGLTREGAPADRECQRGPETIVHEAQDAGTPNSGDATGAVDGEREATMRVPEKYSTLPAEDRSVHIVNICAIEDLGYLPSEGTLLNSLSVDPDAECKYGLYFRDGKRKVDYILVYHHKRASGSRTLARRGLQNDMVLGTRSVRQDQPLPGKGSPVDVGSPEAPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWHVLCREAEFLKLKMPTKKVYHISETRGLLKTINSVLQKITDPIQPKVAEHRPQTTKRLSYPFSREKQHLRKDSALLSKRRKCGKYGITSLLANGVYSAAYPLHDVSNLHLLYEEWASYGVFYKYQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGCATVDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEVSSCDHPRAEYEARVLEKSLRKESRNKETDKVKLTWRDRFPAYFTNLVSIIFMIAVTFAIVLGVIIYRISTAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLTFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKFIRYLKLRRQSPSDREEYIKRKQRYEVDFNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISFTSDFIPRLVYLYMYSQNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQGKQQLLDTWMEKEKPRDVPCNNHSPTAHPEAGDSSPVPSYEYHGGAL
Protein: Nitrosoguanidine resistance protein SNG1 (P46950)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May function as a N-methyl-N'nitro-N-nitrosoguanidine (MNNG) export permease.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Non-classical export protein 2
- Zinc finger transcription factor YRR1
Sequence:
MTKSVGDEESQYIEDPSFAAAAAFTGGRDGVSYSNQRFAEGSGHSSDLAKSLEDYRPPDEKPSSLSSVGEGGANEEEKGGNDGGPLARIQTGLFSPRLRNHRKKILSKFVLNNFFIACVCVSLISIYWGACYGTDRYFFKVKNIVVLQDAPSNTSVQSISAIIPSLLASVPGTWHIYNATSFHRKFGTTNSTEIDRKIVDLIYDERYWLALNVKPNATDTLYNSLISQDANSEFNSSIFFESVFESGRDPSSVKSTILPLMQQLEVRLQKYYVKEYLPSLMSNITSNDRDLNINMENWAIAGQLLFTYNDYRPFADRILMAPLQVGLIYCILLTVLQLSLYGKLHGEMARVLKPKHILIYRLLISWATYFLLSIGFCTVSAIFRIDFTPAFGRGGFVVYWMSTWLVMMAVGGANENVLSLVIAYCPPYLSIWLMTWIILNISASFYPMVLNNEFYRYGYIMPIHNAVDIYKVIFLNLTKRKMGRNYGILVAWVALNTSLMPFCMKFAGKKMQKNAMQAAEAAVAAATQRASRPAEANTDKNNNPPGN
Protein: Endo-1,4-beta-xylanase Z (Xylanase Z) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase Z) (P10478)
Organism: Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)
Interaction partners:
- Beta-xylanase
- Cellulosomal-scaffolding protein A
- Endoglucanase C
- Ricin B lectin
- Intracellular exo-alpha-
Sequence:
MSRKLFSVLLVGLMLMTSLLVTISSTSAASLPTMPPSGYDQVRNGVPRGQVVNISYFSTATNSTRPARVYLPPGYSKDKKYSVLYLLHGIGGSENDWFEGGGRANVIADNLIAEGKIKPLIIVTPNTNAAGPGIADGYENFTKDLLNSLIPYIESNYSVYTDREHRAIAGLSMGGGQSFNIGLTNLDKFAYIGPISAAPNTYPNERLFPDGGKAAREKLKLLFIACGTNDSLIGFGQRVHEYCVANNINHVYWLIQGGGHDFNVWKPGLWNFLQMADEAGLTRDGNTPVPTPSPKPANTRIEAEDYDGINSSSIEIIGVPPEGGRGIGYITSGDYLVYKSIDFGNGATSFKAKVANANTSNIELRLNGPNGTLIGTLSVKSTGDWNTYEEQTCSISKVTGINDLYLVFKGPVNIDWFTFGVESSSTGLGDLNGDGNINSSDLQALKRHLLGISPLTGEALLRADVNRSGKVDSTDYSVLKRYILRIITEFPGQGDVQTPNPSVTPTQTPIPTISGNALRDYAEARGIKIGTCVNYPFYNNSDPTYNSILQREFSMVVCENEMKFDALQPRQNVFDFSKGDQLLAFAERNGMQMRGHTLIWHNQNPSWLTNGNWNRDSLLAVMKNHITTVMTHYKGKIVEWDVANECMDDSGNGLRSSIWRNVIGQDYLDYAFRYAREADPDALLFYNDYNIEDLGPKSNAVFNMIKSMKERGVPIDGVGFQCHFINGMSPEYLASIDQNIKRYAEIGVIVSFTEIDIRIPQSENPATAFQVQANNYKELMKICLANPNCNTFVMWGFTDKYTWIPGTFPGYGNPLIYDSNYNPKPAYNAIKEALMGY
Protein: Pcl5p (Q5AK08)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Amino acid starvation-responsive transcription factor
- Negative regulator of the PHO system
- Pho81p
- Serine/threonine-protein kinase ATG1
- Cyclin-dependent kinase 1
Sequence:
MQSPTSPISYKETSVPSFSKESTTTETSKSLPHANLLTPPTLSPPTITSDLPTSTLSPNHHNYYTHYLNKAQFNSILVNCSINLLKILYKNQKFDEKSIKLFIIEILRRSKTSIQSLQLSCFYIYKLIVAKQKITFDAKKLFLGLIIISSKFNQDYNYSFKSWCKICGLNENSNVKQLVHIESTILQWLNYDLCLIGSKYENWCNLLLIFGYDFIQYQLIFDNRTEIVWNQEIKDKINSWQSFFNQLNLDNLNIINVNFNNYFNNQLNKKVFVVKDEQPTLLSKKRSSTSLFDTEQPVAKKVKA
Protein: Kal1.1 (Q9IAR4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRDGLTGLCIGIILLLNGGLVVMRRQDSSSALGSIFRTRCAARCLSLHSTRIALSPRHFQSNGSLGWCQSHKQCAKCLEPCKDSWELKDGPCRDLCEHAFPKRHGECVTSCEFLRSVMVVKQGDCPPPERASGFAAACVEGCEEDGECSGQKKCCPNGCGHTCQSPKNLYRGAPLKPRKELVFEELESGVLEVRWSSKFNVSAEPVLNVLQRRWNYGIHPSEDGATEWQVVARTSGERVWLTDIRPGRWYQFRVAAVNVHGTRGYTTPSRHFRSSKDPPPPPAPSDLHVSDMTFGADHSASVRLSWSISADLDIPVNHYKLSWSSSDHNLPPKLKKRETVNGDSTYAELDDLRENGSYTVELQAVSYWGQVPLKSSKAILQFTTSQTQSDLEPTVSPVFIKPQSDLLDVGTPFYQDGQLQVRVYWKKKDPTVNRYRVQWAPEFCSHNGSRTQGKLITQENFASLPGLQFSCKYKVIIQPVGLKGRTQVESTTFYTPSCATIQSKSPKPIPCSSVPVVQPKVLVKAENLTAAFSVYLGNVTGLFSWVVAMPQQPQQVTGYQVTWAEVITESRRNNLPNSLISQSQILPPERNILVVSGLQLASLYRLEVQVITAAGQGPATSRTFQTPTHSKPVLHYKPRIKKHHLRSVIERH
Protein: Large ribosomal subunit protein P2C (60S acidic ribosomal protein P2-C) (O14317)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays an important role in the elongation step of protein synthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein uL29
Sequence:
MKYLAAYLLLTVGGKNSPSASDIESVLSTVGIESESERVEALIKELDGKDIDELIAAGNEKLATVPSGGAAAAAAPAAAGGAAPAAEEAAKEEAKEEEESDEDMGFGLFD
Protein: Frizzled-1 (Fz-1) (mFz1) (O70421)
Organism: Mus musculus (Mouse)
Function: Receptor for Wnt proteins. Activated by WNT7B. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (By similarity). Contradictory results showing activation by WNT7B have been described for mouse. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15923619}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein Wnt-3a
- Proto-oncogene Wnt-1
- Low-density lipoprotein receptor-related protein 5
- Protein Wnt-5a
- Tyrosine-protein kinase RYK
- Protein Wnt-2
- Protein Wnt-11
- Protein Wnt-7b
- Low-density lipoprotein receptor-related protein 6
- Protein Wnt-10b
Sequence:
MAEEAAPSESRAAGRLSLELCAEALPGRREEVGHEDTASHRRPRADPRRWASGLLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQSGQQYNGERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGTVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
Protein: 5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2) (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2) (Q7Z4H3)
Organism: Homo sapiens (Human)
Function: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Interaction partners:
- S-methyl-5'-thioadenosine phosphorylase
- Purine nucleoside phosphorylase
- NAD-capped RNA hydrolase NUDT12
- rRNA N
- NAD
Sequence:
MASVSSATFSGHGARSLLQFLRLVGQLKRVPRTGWVYRNVQRPESVSDHMYRMAVMAMVIKDDRLNKDRCVRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKQITQLLPEDLRKELYELWEEYETQSSAEAKFVKQLDQCEMILQASEYEDLEHKPGRLQDFYDSTAGKFNHPEIVQLVSELEAERSTNIAAAASEPHS
Protein: Nuclear factor 1 (A0A8I6AFY4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
Sequence:
MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPNSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSTSPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNSSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLTMTDTKPITTSTEGEAASPTATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQAETSN
Protein: tRNA (adenine(22)-N(1))-methyltransferase (EC 2.1.1.217) (TrMet(m1A22)) (tRNA(m1A22)-methyltransferase) (tRNA(m1A22)MTase) (P54471)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 22 (m1A22) in tRNA.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- GTP cyclohydrolase 1 type 2 homolog
- Uncharacterized protein YlaF
- Uncharacterized protein YlxR
- Uncharacterized lipoprotein YkyA
- TPR repeat-containing protein YvcD
- Uncharacterized sugar epimerase YhfK
- tRNA pseudouridine synthase A
- UPF0122 protein YlxM
- UPF0297 protein YrzL
Sequence:
MNELKLSKRLQTVAEYIPNGAVMADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKSGLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNIHAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFLAKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG