wanglab/gogpt-training-data huggingface dataset:
Protein: ATP-dependent chromatin assembly factor large subunit (Q9V9T4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00475}.
Interaction partners:
- DNA polymerase epsilon subunit 3
- Chromatin-remodeling complex ATPase chain Iswi
- Chromatin accessibility complex 16kD protein
- Nucleosome-remodeling factor subunit NURF301
- Toutatis, isoform E
- Chromatin assembly factor 1 p55 subunit
- C-terminal-binding protein
- Inorganic pyrophosphatase
- Chromodomain-helicase-DNA-binding protein 1
- Uncharacterized protein, isoform B
Sequence:
MPICKREGFDLNQKEGKNETFHDNDQVFCCYITKRIFRDYEHYFRHVMVINSTVWQCEATGKENLTYEEAVKSERAARKKMEQFKQSLRAPVLLVVEHAQQSAVNTLNMIVAKFLRKRYFIGEEVSVQAKKNATYTVLGVKLDKNMPEPLNGIYEDTDNLVYRLRPNKGDPSAELDLPFRQLRRSRMEFNLENLSMFIKSNVSRVDGLLRPKPEAYKQYVTDPGVNFSTIFIGKMPRYSPAKIKKPDGKKQSTLNKYIVAGEATAAKSKAKAKSDAKSLAEELERVKREKEAKLIELEKQKAEKKAQLIERVENECNLLLQKTDDLERTDQKVLPRYRQIVTLLPEHLLGDAFMMREFMHTYTGLLSGIEVFRQNLSFYEMTRALTAREIAGPLSDILLVLLGTVFDLQKEEEEECAVTYLDRAAQTQEPYWSMAQAAKSHLYAKRHFSFKVNELPLDALTLSEVLRLHLLGSGAFVNEKAERWRVMYRNGYSSKEDPGLELRLEHSHILRILKNHSVYQLKFKDIMLLIRCLMSQIMTYSGTINLIEERMEQTAKARQDLRALVVGENKRLAAVEINRKKLTQMHHLEVNGVEPEKREALVEKLKKSIAELHAQSDQQHRKHELQMLKLHSQLFNFLVYLGMDRCYRKYYVLESMPGIFVEHSPDSLDTCLEQPITNKSQIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTKKKAKHSLENKENQEHRLNGSAEPMDVESDSPEAPTHFELLMCSGDKRSCIVHDSRNGQRQRWAYIYKAEEIDELIKALNPNGLREYELLQELSVLRSLIEQHAKTCPVDLLSLENETMRKKFMAAMESETNRKYGEANFGLPNGTDLNEVMRLHLVDRIIQFENDIYTGDLGRLKVKDMEKWRSDLLGGNYDAQCKLQWGPGGKLEDEAGSDNESHETHEEDDGALLGKYARKPYRDPGMYLAASADTKPLPDSDDEEDQHTNAVSIPIAVHNMASALLQVEQAIGKRFLKEPYGMKKWDPKQEALKLACDSRLHQWEVSLMESTSFAQVFLHLNILHDCIQWRRSTNKSLCKVCRRGSDPEKMLLCDECNAGTHMFCLKPKLRSVPPGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDDDMTDEDAEHENEKHDEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLTSKEIEEHAQEDVDSGDVSDDASLTAGEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQRPRRRHSNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNNNNHRRSGRRTNEHMPLNSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDAGCQLERFVIDRCRDMQLPFRPSDMNGEVKAC
Protein: Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 3 (Protein ORGAN BOUNDARY 1) (O82268)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription regulator that acts as a developmental regulator by promoting cell growth in response to light (By similarity). Required for the maintenance of the shoot apical meristem and for the formation of lateral organs. Promotes petal formation and growth, but may suppress organ differentiation in the boundary region.
Subcellular location: Nucleus {ECO:0000269|PubMed:21245300, ECO:0000269|PubMed:21435050}.
Interaction partners:
- Protein CUP-SHAPED COTYLEDON 1
- F23A5.30 protein
- Transcription factor MYB117
- Protein CUP-SHAPED COTYLEDON 2
- Protein CUP-SHAPED COTYLEDON 3
Sequence:
MDMIPQLMEGSSAYGGVTNLNIISNNSSSVTGATGGEATQPLSSSSSPSANSSRYENQKRRDWNTFGQYLRNHRPPLSLSRCSGAHVLEFLRYLDQFGKTKVHTNICHFYGHPNPPAPCPCPLRQAWGSLDALIGRLRAAFEENGGKPETNPFGARAVRLYLREVRDMQSKARGVSYEKKKRKRPLPSSSTSSSSAVASHQQFQMLPGTSSTTQLKFEK
Protein: Stac-like, isoform T (A8DYE4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MGISAHAAPASFWNHPRRIRRTPTSDRDGVDQCRPWICRRKDRRPAHPAANRPPESRVCGPSSTFRWDDWAAPAPRTRERATDCARMCMCTSRIPYSVARICARTTSMHSSRPASRSSSFIRRPLTRRQRMAVGGVTRRLWRTMRVYTIHQGRGVRRARAAQAVAAYLRDRRARIGKGWPAQGHGVRISATEQWADKPVVRRPGDPTRRVAAGAVPVLAERLPKVTGSSVKSSSGRRSRRRRIFGWRGPRGGSLSPQGGSMASYNGVLKDYSHSSLNEAFKSQNNVNFKLIKTVSDFSETLSRLYEEHATALQVAVSNYRKKNAELRKERPACHLAIFQAWETFLQEVETDSQACNDVASVLSRQVSRPMLDKSFHRKVQSRKIFTHRESFETIIAKTEEKLSKCRVDYKQCHLAHRQNPSQHSLTEYIDAHNAYVQQLHATNGMLEAYHTDTLPQQMQELEEIHNDLVAIVSDSLMQGAEVIAGKANDQAKRYNSLSNQCAAVSPQQDLVNFVRLLAQPSQAQKIPRRLFASPQAEVGEEAGDHNEMTPCLRNELVFDRHSTLSQRSALESLKREAIELELQIRQLQDSIEALNRTQTRGIEGQLYNKVNELQEDLSMKKFDLRAKQIHLAAIRAQKDLFVSKVEPTSPRNERKFSAATAPSMKTKWLKAFKSLKPAGSGSAQQADRRNGASSTASEPLRPNLDGSHHLQEYTYKKITACDVCSQILRGHTRQGLRCRICKLNAHGDCAPNLPRCQPKQKLLRRQKSTSELENRVDIEEETSPQESLVAAAADQADDPSPNLNMNTNTNTITNPSANQLNVPNAKFRQKTPFMHRIAQLASANPKSETTRPFGEPLMLLKSTESNPDESKGNRRVR
Protein: Ceramide kinase (AtCERK) (EC 2.7.1.138) (Protein ACCELERATED CELL DEATH 5) (Q6USK2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Possesses high activity on ceramide analogs (C6, C8 synthetic ceramides) and lower activity on C6 and C8 dihydroceramides. Has weak activity on natural ceramides (a mixture of ceramides from bovine brain) and the synthetic substrate C2 ceramide. Has very poor activity on diacylglycerol and sphingosine. Ceramide is a critical sphingolipid metabolite that induces programmed cell death (PCD) in plants and ceramide-1-phosphate has a PCD suppressive effect. Thus, ceramide phosphorylation plays a role in the modulation of PCD and CERK activity is crucial for the maintenance of cell viability.
Interaction partners:
- Neutral ceramidase 1
- Neutral ceramidase 2
- Non-lysosomal glucosylceramidase
- Non-lysosomal glucosylceramidase
- Neutral ceramidase 3
- Non-lysosomal glucosylceramidase
- Non-lysosomal glucosylceramidase
- Long chain base biosynthesis protein 1
- Long chain base biosynthesis protein 2a
- Sphingolipid delta
Sequence:
MEEGRDDEYCSFSNSGDRDGGLSGCFFLDHVGQVLLSRNHDGLSWKCLDSSDCEGTTCLGIIICENSETEIKFSDIYAVEFVSYGLVHSPKLGLRHAKECFRERLLNTQEMYRFTVHGFQSSPKEPCLWNLAAFTFGHMDLQTCQSWMDQLNYSLIKEVERPRNLLVFVHPKSGKGNGSKVWETVSKIFIRAKVNTKVIVTERAGHAFDVMASIQNKELHTYDGIIAVGGDGFFNEILNGYLLSRLKVPLPPSPSDSFNSVQSRGSSSVPEPGDEVHETDQKEHYPLLPDSVQEVMNFRTVNGSCEGIEDPDHPFSSERPRFGLIPAGSTDAIVMCTTGARDPVTSALHIILGRKLFLDAMQVVRWKTASTSTIEPYIRYAASFAGYGFYGDVISESEKYRWMGPKRYDYVGTKIFLKHRSYEAEVMFEEAESENSKASLHTRSKTWPFRNTTRSEKILCRANCKICNSKVGWNSASTTLNPCPEKTRWCRTKGRFLSIGAAVMSNRNERAPDGLVVDAHLSDGFLHLILIKDCSRPKYLWHLTELAKRGGEPLNFEFVEYHKTRAFTFTSFGEESVWNLDGEIFEAHQLSAQVLRGLIPLFASGPEI
Protein: Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (GLUT-R) (Solute carrier family 1 member 2) (P31596)
Organism: Rattus norvegicus (Rat)
Function: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:1448170, ECO:0000269|PubMed:7913472}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43004}.
Interaction partners:
- Excitatory amino acid transporter 1
- Amino acid transporter
- Aquaporin-4
- Glutamine synthetase
- Alpha-synuclein
- Glial fibrillary acidic protein
- Glutamate receptor ionotropic, NMDA 2B
- Disks large homolog 4
- ATP-sensitive inward rectifier potassium channel 10
- Cytosolic 10-formyltetrahydrofolate dehydrogenase
Sequence:
MASTEGANNMPKQVEVRMHDSHLSSEEPKHRNLGMRMCDKLGKNLLLSLTVFGVILGAVCGGLLRLAAPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISLLNETMNEAPEETKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRMHEDIEMTKTQSVYDDTKNHRESNSNQCVYAAHNSVVIDECKVTLAANGKSADCSVEEEPWKREK
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Complex I-ASHI) (CI-ASHI) (NADH-ubiquinone oxidoreductase ASHI subunit) (O95169)
Organism: Homo sapiens (Human)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- Acyl carrier protein, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 subunit C2
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial
Sequence:
MAVARAGVLGVQWLQRASRNVMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLNWGEPMHWHLDMYNRNRVDTSPTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVGPKQYPYNNLYLERGGDPSKEPERVVHYEI
Protein: Biotin transporter (Plasmamembrane biotin transport protein) (P0ADP5)
Organism: Escherichia coli (strain K12)
Function: Uptake of biotin. Acts probably by facilitated diffusion.
Subcellular location: Cell inner membrane {ECO:0000269|Ref.5}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Lysophospholipase L2
- Pyridoxal phosphate phosphatase YigL
- Uncharacterized protein YhfT
- Uncharacterized protein YhfS
Sequence:
MALLIITTILWAFSFSFYGEYLAGHVDSYFAVLVRVGLAALVFLPFLRTRGNSLKTVGLYMLVGAMQLGVMYMLSFRAYLYLTVSELLLFTVLTPLYITLIYDIMSKRRLRWGYAFSALLAVIGAGIIRYDQVTDHFWTGLLLVQLSNITFAIGMVGYKRLMETRPMPQHNAFAWFYLGAFLVAVIAWFLLGNAQKMPQTTLQWGILVFLGVVASGIGYFMWNYGATQVDAGTLGIMNNMHVPAGLLVNLAIWHQQPHWPTFITGALVILASLWVHRKWVAPRSSQTADDRRRDCALSE
Protein: Interleukin 17 receptor B (C9IZN0)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MSLVLLSLAALCRSAVPREPTVQCGSETGPSPEWMLQHDLIPGDLRDLRVEPVTTSVATGDYSILMNVSWVLRADASIRLLKATKICVTGKSNFQSYSCVRCNYTEAFQTQTRPSGGKWTFSYIGFPVELNTVYFIGAHNIPNANMNEDGPSMSVNFTSPGSLWDPNITACKKNEETVEVNFTTTPLGNRYMALIQHSTIIGFSQVFEPHQKKQTRASVVIPVTGDSEGATVQLTPYFPTCGSDCIRHKGTVVLCPQTGVPFPLDNNKSKPGGWLPLLLLSLLVATWVLVAGIYLMWRHERIKKTSFSTTTLLPPIKVLVVYPSEICFHHTICYFTEFLQNHCRSEVI
Protein: Probable arginine--tRNA ligase, mitochondrial (EC 6.1.1.19) (Arginyl-tRNA synthetase) (Q8SXK2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- Tyrosine--tRNA ligase
- Methionine--tRNA ligase, mitochondrial
- leucine--tRNA ligase
- leucine--tRNA ligase
- Tryptophan--tRNA ligase, mitochondrial
- Tryptophan--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase
- Probable glutamine--tRNA ligase
- Tyrosine--tRNA ligase, mitochondrial
Sequence:
MERPHIGLFTYKICNALKELTERMIRLRQAICEQLPHLKNACYALEVPVKKQQLQNSRRPTVEWILPSAFAQQEVELLDSLKKRRFEAYVENVRIVPSAGRSAAKIEFQLQPQVFVEQLLQTKEIALHPSPFAAEHIVVEYSSPNIAKPFHVGHLRSTIIGNVLANLHEHLGYRTTRLNYLGDWGTQFGLLVLGVQLLNVSDKEMQLSPIETLYKSYVAANKAAEQRPEIAQQARDLFAALEGGTDKSMAKKWQQYRNYTIEDLSKVYNRLGVHFDSYEWESQYSQQQIQDVLDKLRSAGLLQPEHDGREIVVVDGRRIPVIKSNGSTLYLARDIAALLERLSRFQFSRLLYVVDNGQADHFNALFKTTAALDDRLSLEQLQHVKFGRIYGMSTRQGKAIFLKDVLDEARDIMREKRNISATTRENYNLDDEHVCDILGVSAVLVNVLKQRRQRDHEFSWQQALQVNGDTGIKLQYTHCRLHSLLDNFRDVDLDDIKPDWKHFSTEPADALDLLYALARFDQSVWQSKEQLEACVLVNYLFGLCNATSQALKRLPVKQESSLEKQLQRLLLFHAAKKTLRHGMELLGLRPLNQM
Protein: UGT protein (A3FMH3)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MEKQQKSGHLVLVMAPFQGHLTPMLQLATILHSKGFSITIVHPELNSLNPSNHPEFTFVPIPDKIKESQLSDEDLADKLKESLVSTVDVAGSVQSLNKNCAAPLKKCLENILHSHHHIAAVIYDTLMFCAQTIVNDLGLPGITLRTSSATTLLLFPVLPQLGEKELMSGIESPELQALQLQRLRALIVQNPTQAMMEVRAAFTNAMKFSSAIIVNSMEFLELEALSKVRQYFRTPIFIVGPLHKLAPAICGSLLTEDDKCISWLNKQAPKSVIYVSLGSIANIDKQELIETAWGLSNSKQPFLWVVRPGMVCGSEWIESLSNGFEENVGERGCIVKWAPQKEVLAHGAVGGFWSHCGWNSTIESICEGVPMLCRPFFGDQLLNTSYICNVWKIGLELQNLERGNIERTIKRLMVDMEGKDIRKRAMDLKKKAALCLMEDGSTSSFNGLIKQITVSET
Protein: Forkhead box protein N1 (Winged-helix transcription factor nude) (O15353)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny.
Subcellular location: Nucleus.
Interaction partners:
- Protein Wnt-5b
- Homeobox protein Hox-C13
- Autoimmune regulator
- Transcription elongation factor SPT6
- Protein Wnt-10b
- Chorion-specific transcription factor GCMb
Sequence:
MVSLPPPQSDVTLPGPTRLEGERQGDLMQAPGLPGSPAPQSKHAGFSCSSFVSDGPPERTPSLPPHSPRIASPGPEQVQGHCPAGPGPGPFRLSPSDKYPGFGFEEAAASSPGRFLKGSHAPFHPYKRPFHEDVFPEAETTLALKGHSFKTPGPLEAFEEIPVDVAEAEAFLPGFSAEAWCNGLPYPSQEHGPQVLGSEVKVKPPVLESGAGMFCYQPPLQHMYCSSQPPFHQYSPGGGSYPIPYLGSSHYQYQRMAPQASTDGHQPLFPKPIYSYSILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKSGSSSRKGCLWALNPAKIDKMQEELQKWKRKDPIAVRKSMAKPEELDSLIGDKREKLGSPLLGCPPPGLSGSGPIRPLAPPAGLSPPLHSLHPAPGPIPGKNPLQDLLMGHTPSCYGQTYLHLSPGLAPPGPPQPLFPQPDGHLELRAQPGTPQDSPLPAHTPPSHSAKLLAEPSPARTMHDTLLPDGDLGTDLDAINPSLTDFDFQGNLWEQLKDDSLALDPLVLVTSSPTSSSMPPPQPPPHCFPPGPCLTETGSGAGDLAAPGSGGSGALGDLHLTTLYSAFMELEPTPPTAPAGPSVYLSPSSKPVALA
Protein: Protein stum homolog (Q69YW2)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEPSHKDAETAAAAAAVAAADPRGASSSSGVVVQVREKKGPLRAAIPYMPFPVAVICLFLNTFVPGLGTFVSAFTVLCGARTDLPDRHVCCVFWLNIAAALIQILTAIVMVGWIMSIFWGMDMVILAISQGYKEQGIPQQL
Protein: Probable threonine/serine exporter (O69704)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the export of L-threonine and L-serine from the cell to the extracellular environment (By similarity). Export is dependent on the proton motive force (By similarity). Required for in vitro growth and survival of bacteria inside macrophages.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Transcriptional regulatory protein
Sequence:
MDQDRSDNTALRRGLRIALRGRRDPLPVAGRRSRTSGGIDDLHTRKVLDLTIRLAEVMLSSGSGTADVVATAQDVAQAYQLTDCVVDITVTTIIVSALATTDTPPVTIMRSVRTRSTDYSRLAELDRLVQRITSGGVAVDQAHEAMDELTERPHPYPRWLATAGAAGFALGVAMLLGGTWLTCVLAAVTSGVIDRLGRLLNRIGTPLFFQRVFGAGIATLVAVAAYLIAGQDPTALVATGIVVLLSGMTLVGSMQDAVTGYMLTALARLGDALFLTAGIVVGILISLRGVTNAGIQIELHVDATTTLATPGMPLPILVAVSGAALSGVCLTIASYAPLRSVATAGLSAGLAELVLIGLGAAGFGRVVATWTAAIGVGFLATLISIRRQAPALVTATAGIMPMLPGLAVFRAVFAFAVNDTPDGGLTQLLEAAATALALGSGVVLGEFLASPLRYGAGRIGDLFRIEGPPGLRRAVGRVVRLQPAKSQQPTGTGGQRWRSVALEPTTADDVDAGYRGDWPATCTSATEVR
Protein: DNA repair protein rad8 (EC 3.6.4.-) (DNA repair protein RAD5 homolog) (P36607)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats (By similarity). Plays a role in surviving topoisomerase-mediated DNA damage.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P32849}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Postreplication repair E3 ubiquitin-protein ligase rad18
- Proliferating cell nuclear antigen
- DNA repair protein rhp51
- Ubiquitin-conjugating enzyme spm2
- Ubiquitin-conjugating enzyme E2 13
- ATP-dependent DNA helicase srs2
- General transcription and DNA repair factor IIH helicase subunit XPD
- DNA polymerase zeta catalytic subunit
- DNA repair protein rad13
- ATP-dependent DNA helicase fml1
Sequence:
MKRKVQKIIDEAPLEENSPPRFFDSDVEADSKPNDLTAANSIVDLKTNSQHENANAAGKEYGDSGVSESWVLDFLSVTGEKTISEFLAQKIWKTSNGDLNVAVDMYFDESFNIKNSNPDSESQKDTDASLTQMDQLSNTVSVKDLSINRNTNKKALNAVSPSLNLSSNSSVQDVSIDKEEMMKKQSRNALTPLDFIMKKNELMKYIGCFGVEAYSTASGTRTLQAGERIYLERQKLSIKSQSRNSRKKSKLLSINSSCYSNIVRFCNSDHHEIGKLPTEVASVISTLMEQGFWSFEAICIYSDNIIRFGSNVTLQVYCFINVNHPSLNRSPFTLATNSMQEEEEHLKASFAQNKRDHLLRLFTWIALEPDLEDCNTKESIHIDDILKTSSLPEARDESNSDLTPSSTEDEEDVVSDQLAILYDKVKTSGAELPSAPKPSTFALDLREYQKQALYWMCCKEEGVQSDGSAPKLHPLWSRFRFPKDSEFPEFFKCSSDDDNTHFYVNLYTGETTMLFPNSMPYHRGGILADEMGLGKTIEVLSLIHSRPCFSTDEIPEAFRHSKPSLPVASRTTLVVAPMSLLDQWHSEACKVSQGTKFRSMIYYGSEKPLDLKSCVIDTSTAPLIIITSYGVLLSEFSQQSHSSGLFSVHWFRVVLDEGHNIRNRESKTAKACHSISSQNRWVITGTPIVNKLDDLYSLIKFMRYEPWCNYTYWQTFVSLPYQSKDVLKALNVVQSILEFLVLRRTKETKDRNGNSIVTLPPKTVKIEYLDFSDSERKIYDSLYTKAKSTVNANIVAGTLFRNYTTILGLLLRLRQACCDPVLLSNMTINSETFDDFEFSVEQFNSLINQFVVTGKPIPSDILKIDTLKSFEALITECPICCNEPIQNPLLLNCKHACCGDCLSEHIQYQKRRNIIPPLCHTCRQPFNEQDVYKPFFVKNNGTQSTLLVGEEVKWKYWNRLQSVKLNGLLGQLRQLTHSSEPEKVVIFSQFTTFLDIIADVLESEKMGYARFDGTMSQQMRSTALETFRNDPDVNVLIISLKAGGVGLNLTCANHVFIMDPWWSWSVEAQAIDRIHRLGQEKPVFVTRYIVRDTVEERMLKIQERKNFITGTLGMSEGKQQVQSIEDIKMLFEY
Protein: Probable intramembrane protease C25B8.17 (EC 3.4.23.-) (Q9UTA3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}. Golgi apparatus membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MEGVILASSALFTVYIGAKWSAQEEEPEEKQLINKRLAVLFPIFGGVTLVLMYLALRYLSKEYIQLILQGYASLASIICFVRSFNPKTTFGKITATMSSIAIALFYFKTKHWMASNILAWALAANSISIMRIDSYNTGALLLGALFFYDIYFVFGTEVMVTVATGIDIPAKYVLPQFKNPTRLSMLGLGDIVMPGLMLALMYRFDLHYYINSTSQPKKHSTYFRNTFIAYGLGLGVTNFALYYFKAAQPALLYLSPACIVAPLLTAWYRDELKTLFSFRSETEDETDEQDKCKST
Protein: Precursor of CEP1 (PCEP1) [Cleaved into: C-terminally encoded peptide 1 (CEP1)] (Q8L8Y3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signaling peptide that represses, in a dose-dependent manner, primary root growth rate and lateral root elongation by inhibiting both cell division in meristems and cell growth in elongation zones. Prevents also slightly growth of above-ground parts. Regulates systemic nitrogen (N)-demand signaling. Mediates systemic up-regulation of genes involved in N uptake and assimilation pathways (e.g. NRT1.1, NRT2.1 and NRT3.1).
Subcellular location: [C-terminally encoded peptide 1]: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:18315543}. Note=Accumulates in xylem sap under nitrogen (N)-starved conditions. {ECO:0000250|UniProtKB:O80460}.
Interaction partners:
- Receptor protein-tyrosine kinase CEPR1
- Receptor protein-tyrosine kinase CEPR2
- Transmembrane protein
- At4g37295
- Precursor of CEP16
- F28L1.2 protein
- At2g23270
- PAMP-induced secreted peptide 2
- Protein GOLVEN 11
- CLAVATA3/ESR
Sequence:
MGMSNRSVSTSIFFLALVVLHGIQDTEERHLKTTSLEIEGIYKKTEAEHPSIVVTYTRRGVLQKEVIAHPTDFRPTNPGNSPGVGHSNGRH
Protein: WD repeat-containing protein fzy-1 (CDC20 protein family homolog 1) (Fizzy protein 1) (Q09373)
Organism: Caenorhabditis elegans
Function: Plays a role in metaphase-anaphase transition during meiosis I. Required for embryonic anterior-posterior axis formation.
Subcellular location: Chromosome {ECO:0000269|PubMed:12498686}. Cytoplasm {ECO:0000269|PubMed:12498686}. Note=At prometaphase, localizes around condensed chromosomes. At metaphase, localizes along chromosomes, dissociates from the sister chromatid after separation and localizes to the cytoplasm at anaphase and interphase. {ECO:0000269|PubMed:12498686}.
Interaction partners:
- Mitotic spindle assembly checkpoint protein MAD2A
- Mitotic checkpoint protein bub-3
- Abnormal embryogenesis protein 30
- Cell division cycle protein 23 homolog
- Cell division cycle protein 16 homolog
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 1
- Protein gfi-3
- Anaphase-promoting complex subunit 11
Sequence:
MNNKGRTPGSAGRTVRSSAQQNGLTMRKRDMTPTRNTNLLPNATFVGDRFLGVRLDQDELDHANHLMTSKLYSNKENLNNSMSEPNSPEKKSVEGEALKQMMRHKSTGALTDADDGDRILCYKKNLAPPPAIGYINQAKVLYSTNSVINPASSVKKSTRHVKETATKVLDGPGLTKDLYSRHLDWGCHNWVAVALGHELYLWNTETCVIKNLFEDNAPTNEGLITSVRWSQEGRYISLGYASGAVKIYDPNRPKTTEYVRELRTLRVGGASRCASIAWRKQGVMTCGYKSGDIVNHDVRISQHVVSSWGGDNGHCRDVTALEWSADENMCVSGSSDRTAKIWDGRHVRGSTVIQDPEPMFTIDEHTGQVRTAQFCSFRDGILATGGGINDGTVKLWDVKRQFQKVRELNVCETGGVGGIVFNRPYSEMLTASDDGFLRIYRFNANYKLSHEIQASNEPIMDLVGSPFDEVLIGDMEETLKVFQLFNVDKSTNILDRTAPKNVGLNVR
Protein: Guanylate kinase, putative (EC 2.7.4.8) (Q38AS6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- adenine phosphoribosyltransferase
- adenine phosphoribosyltransferase
- GMP synthase
- Pyruvate kinase
- Ribonucleoside-diphosphate reductase
- Nucleoside diphosphate kinase, putative
- Nucleoside diphosphate kinase, putative
- Nucleoside diphosphate kinase
- Hypoxanthine phosphoribosyltransferase
- Hypoxanthine phosphoribosyltransferase
Sequence:
MLPPPHPREDEDLTRQRHSPAHIIVFVGPSGCGKSTLADEIMKRWPNRFAFSVSHTTRKPRKNEVNGKHYHFVSKEKFLQLLADGLFAEHSKSFTKAKRNTSDDCGPRGSGAEEDDEDTVYYGTSKMALHDVLSNGRIVLMDTDISGAIKIKRYCDEINTQLTGKTEQSVVQSNAGVIRRLQLHLIFVKCPNLEVGEQRLRNRGTETLTSLQRRFLSNRQCIQWYNAHTGFFNLTLVNDTLERCLEDLFSYVSGKILCSPSSKL
Protein: Tumor-associated glycoprotein E4 (Q60977)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAPLAGASRSRVWSVGLLRLLLLSCFTLQKAGGEIAVQVLSNSTGFLGGSTVLHCSLASKDNVTITQLTWMKRDPDGSHPSVAVFHPKKGPSISDPERVKFLVAKVYEDLRNASLAISNLRVEDEGIYECQIATFPTDSKSANVWLKVFARPKNTAEALEPSPTLILQDVAKCISANGHPPGRISWPSNVNGSHREMKEPGSQPGTTTVTSYLSMVPSHQADGKNITCTVEHESLQELDQLLVTLSQPYPPENVSISGYDGNWYVGLTNLTLTCEAHSKPAPDMAGYNWSTNTGDFPNSVKRQGNMLLISTVEDGLNNTVIVCEVTNALGSGQGQVHIIVKEKPENMQQNTRLHLGYIFLIVFVLAVVIIIAALYTIRRCRHGRALQSNPSERENVQYSSVNGDCRLNMEPNSTR
Protein: (S)-1-Phenylethanol dehydrogenase (EC 1.1.1.311) (Q5P5I4)
Organism: Aromatoleum aromaticum (strain DSM 19018 / LMG 30748 / EbN1) (Azoarcus sp. (strain EbN1))
Function: Catalyzes the NAD-dependent stereospecific oxidation of (S)-1-phenylethanol to acetophenone in the degradation of ethylbenzene.
Interaction partners:
- Gamma-subunit of ethylbenzene dehydrogenase
- Beta-subunit of ethylbenzene dehydrogenase
- Alpha-subunit of ethylbenzene dehydrogenase
- Acetophenone carboxylase delta subunit
- Acetophenone carboxylase gamma subunit
- Acetophenone carboxylase epsilon subunit
- Acetophenone carboxylase alpha subunit
- Acetophenone carboxylase beta subunit
- Delta-subunit of ethylbenzene dehydrogenase
- Predicted MaoC-like
Sequence:
MTQRLKDKLAVITGGANGIGRAIAERFAVEGADIAIADLVPAPEAEAAIRNLGRRVLTVKCDVSQPGDVEAFGKQVISTFGRCDILVNNAGIYPLIPFDELTFEQWKKTFEINVDSGFLMAKAFVPGMKRNGWGRIINLTSTTYWLKIEAYTHYISTKAANIGFTRALASDLGKDGITVNAIAPSLVRTATTEASALSAMFDVLPNMLQAIPRLQVPLDLTGAAAFLASDDASFITGQTLAVDGGMVRH