wanglab/gogpt-training-data huggingface dataset:
Protein: Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13) (Q14344)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10747909}; Lipid-anchor {ECO:0000269|PubMed:10747909}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm {ECO:0000269|PubMed:10747909, ECO:0000269|PubMed:18703424}. Nucleus {ECO:0000269|PubMed:18703424}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424). In round spermatids, also present in the nuclei (PubMed:18703424). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18703424}.
Interaction partners:
- Rho guanine nucleotide exchange factor 1
- Sphingosine 1-phosphate receptor 2
- Rho guanine nucleotide exchange factor 12
- Rho guanine nucleotide exchange factor 11
- Integrin beta-3
- Guanine nucleotide-binding protein subunit alpha-12
- Transforming protein RhoA
- Guanine nucleotide-binding protein G
- Sphingosine 1-phosphate receptor 3
- Estrogen receptor
Sequence:
MADFLPSRSVLSVCFPGCLLTSGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNSNQQHGDKMMSFDTRAPMAAQGMVETRVFLQYLPAIRALWADSGIQNAYDRRREFQLGESVKYFLDNLDKLGEPDYIPSQQDILLARRPTKGIHEYDFEIKNVPFKMVDVGGQRSERKRWFECFDSVTSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQIVSIKDYFLEFEGDPHCLRDVQKFLVECFRNKRRDQQQKPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLMLQ
Protein: Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Q54UU3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62753}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62753}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS8
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein eS8
Sequence:
MKLNIAYPVNGSQKKINIEDKNKVRCFMEKRIGQEVEATTLGDEFKGYVFKITGGNDTEGFPMMQGVGAPTRVRLLLDGRSGCFKPSRDGERKRKSVRGCIVAEDIASLQLIIVKKGDAEIPGLTDVSFPASKGPKRASNIRKLFKLSKDEDVRSFVIRRELPATDKRKAKSKAPKIQRLVTPTTVARRKALRAKKAARHTKASNEAAEYAKLVAQRQQAKAKRSVKVSSKKVVAK
Protein: Neurexin 1, isoform E (A0A0B4KGQ3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKAPHSATYQDNYADAAMTARTRPSMDMDQQRNRNQAELRLLPAQRTSTSAFESPDLRFNKARRRRRSEQVPPVVVEYRRSYRVLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVDGVSQQRSTKGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSSRVYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQANVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMPNFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCEGPTKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVLLRVESATTQDYMELEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQLTPASGYPGALDDLIFSGAGSGCRGDDEDECTPPFESGSGDDLITPVYVPPTKQTTTSQQGNSLSTGGSSSGGVITNGTERACDDEDCVHGSGDYGETTEQFTSTSTARGSESNNEMVTITTTGRSDVTTEQHQGSSSSSSSGSTPSYATTQSSSSSSSGGSAASTPGQVSTTSSVATSSTQRATSSSTSTSSSTTSTTTTTTTTQATPPPEIRSTVTERETTPYDIYIAGGGMGGSGRNDHDRMQLPDEHHPLPPLPPPIPPQDPPPYGPYGGNTYNTNMNNYRPKGKGGRINSIEEERTAMIIGIVAGILIAVVLVILLVLWLKSNGDRGYKTESEKAAAYGSHNPNAALLGNTSTNGSYHQQRQHHMHGGGGGGGAGQQQHHAQQQMHNGHNGNGNGGGGGGGGMMSSGSGSLGYGSDGRPQMAGLVQPKAKKRDSKDVKEWYV
Protein: eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] (Q91YR5)
Organism: Mus musculus (Mouse)
Function: Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (By similarity). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (By similarity). Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (By similarity). Has no activity towards core histones H2A, H2B, H3 and H4 (By similarity). Negatively regulates cell proliferation at G1/S transition via transcriptional suppression of cell cycle regulatory genes such as CDK4 and CDK6 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27659353}. Nucleus {ECO:0000269|PubMed:27659353}. Mitochondrion {ECO:0000269|PubMed:27659353}.
Interaction partners:
- N
- EEF1A lysine methyltransferase 2
- Pre-mRNA-splicing regulator WTAP
- Probable methyltransferase-like protein 25
- RNA N
- Protein virilizer homolog
Sequence:
MNLLPKSSKEFGSADYWEKFFQQRGKTAFEWYGTYLELCEVLHKYIKPKEKVLVIGCGNSELSEQLYDVGYQDIVNIDISEVVIKQMKERNGSRRPHMSFLKMDMTQLEFPDATFQVVLDKGTLDAVLTDEEEVTLRQVDRMLAEVGRVLQVGGRYLCISLAQAHILKKAVGHFSREGWMVRAHQVASSQDRVSEAEPRFSLPVFAFVMTKFRPVPGSALQIFELCTQEQGKPVRLESADQLAEAVRERQYYAWLCSQLRRKAGLGSVSLDLCSGDTGEPRYTLHVVDNPAVKPSRDNHFAIFIIPQGRETEWLFGMEEGRKQLAASAGFRRLVTVALHRGQRYAGMESIQAELSARVMELAPAGLPPQQQVPFLSVGGDIGVRTVQHQDHSALSGDYVIEDVQGEDRWYFRRLIFLSNRNVVQSEARLLKDTSHRAQKKRKKDRKKQRPADTSEDFPPAPGQSIDKSYLCCEHHKAMVAGLALLRNPELLLETPLTLLVVGLGGGSLPLFVHDHFPKSRIDAVEIDPTMLEVATQWFGFSQSDRMKVHIADGLDYITSLAGEAPPHYDVIMFDVDSKDPTLGMSCPPPAFVDQVFLQKVKSILCHDGVFILNLVCRDVRLKDSVLAGLKAAFPLLYVRRIEGEVNEILFCQLHPEQKLATPELLEMAQVLERTLRKPGQGWDDTYVLSDMLKTVKIV
Protein: Histone-lysine N-methyltransferase, H3 lysine-9 specific (EC 2.1.1.355) (EC 2.1.1.366) (EC 2.1.1.367) (Cryptic loci regulator 4) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (HKMT) (Lysine N-methyltransferase 1) (Protein lysine methyltransferase clr4) (PKMT) (O60016)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Histone methyltransferase which contributes to the establishment of heterochromatin by specifically methylating histone H3 to form H3K9me. Part of the Clr4 methyltransferase complex (ClrC). ClrC preferentially ubiquitylates H3K14 and ClrC-mediated H3 ubiquitination promotes clr4 methyltransferase activity. Clr4 functions as a reader and writer of H3K9 methylation. It sets the H3K9me mark and afterwards this H3K9me mark is recognized by the chromodomains of clr4 and swi6/HP1, which then recruit additional clr4 leading to the methylation of neighboring nucleosomes. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeres, ribosomal DNA repeats, and the silent mating-type region. Clr4 methyltransferase activity promotes the assembly of a tripartite complex composed of ClrC and complexes involved in siRNA generation. Apart from H3K9, methylates also non-histone proteins such as mlo3. Interacts with mlo3 to promote the processing of centromeric and antisense RNAs.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:18345014}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}. Chromosome {ECO:0000269|PubMed:18345014, ECO:0000305|PubMed:16823372}.
Interaction partners:
- Rik1-associated factor 2
- Histone H3.1/H3.2
- Cullin-4
- Chromatin modification-related protein rik1
- Rik1-associated factor 1
- Chromatin-associated protein swi6
- Protein Dicer
- Protein argonaute
- Putative JmjC domain-containing histone demethylation protein 1
- Histone deacetylase clr3
Sequence:
MSPKQEEYEVERIVDEKLDRNGAVKLYRIRWLNYSSRSDTWEPPENLSGCSAVLAEWKRRKRRLKGSNSDSDSPHHASNPHPNSRQKHQHQTSKSVPRSQRFSRELNVKKENKKVFSSQTTKRQSRKQSTALTTNDTSIILDDSLHTNSKKLGKTRNEVKEESQKRELVSNSIKEATSPKTSSILTKPRNPSKLDSYTHLSFYEKRELFRKKLREIEGPEVTLVNEVDDEPCPSLDFQFISQYRLTQGVIPPDPNFQSGCNCSSLGGCDLNNPSRCECLDDLDEPTHFAYDAQGRVRADTGAVIYECNSFCSCSMECPNRVVQRGRTLPLEIFKTKEKGWGVRSLRFAPAGTFITCYLGEVITSAEAAKRDKNYDDDGITYLFDLDMFDDASEYTVDAQNYGDVSRFFNHSCSPNIAIYSAVRNHGFRTIYDLAFFAIKDIQPLEELTFDYAGAKDFSPVQSQKSQQNRISKLRRQCKCGSANCRGWLFG
Protein: Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B') (P14678)
Organism: Homo sapiens (Human)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
Interaction partners:
- 116 kDa U5 small nuclear ribonucleoprotein component
- Splicing factor 3A subunit 3
- U6 snRNA-associated Sm-like protein LSm2
- Splicing factor 3B subunit 4
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein G
- Splicing factor 3A subunit 2
- Pre-mRNA-processing-splicing factor 8
- U2 small nuclear ribonucleoprotein A'
Sequence:
MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAEREEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGIGRAAGRGIPAGVPMPQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAAAATASIAGAPTQYPPGRGGPPPPMGRGAPPPGMMGPPPGMRPPMGPPMGIPPGRGTPMGMPPPGMRPPPPGMRGPPPPGMRPPRP
Protein: ELMO domain-containing protein (Q38B09)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGTSSTDLTVVSPDAVVLSYRNSDDIIATPCELDQQHQQQLQLQLEQQLHGNVVMGCVQSLKASEDAFPEAFSPSESITGNVVIADTSRHKYSESERESKSRKCDSSVPSIDWDDVNDATMRRVLSVMSLSHADTGESFRSISFVDAVRALKHDRSSWEPYAIPLRARGRGRCLRLRGFLRKVFFCCNSSSSLDSQTNADAPIDPKNPKQVLQQDVDFCSTLPSMPFDHSNPIHRRLLITLRNVLIRDAEEHNGNVWNEWEKLGFQGSDPATDLRSTGLFGLLQLVFLLEYYRAFGFRLWDTCIKKGEDGDNVFEELPFVLIGFNFTGVVLDQLKDTRTHAEMMRRARSSGGEGRGGKQNISPLPLHPQCEETLRREFPFLITCCEYYVGCLFQFLELWLELKKQRGGRAPMIGDFNVVKVKLCASIKRKGAPQIFSACSSARHPVPSPEGDHDDNNEE
Protein: BRO1 domain-containing protein (H8ESG1)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endosome {ECO:0000256|ARBA:ARBA00004177}.
Interaction partners:
- Tumor susceptibility gene 101 protein
- Core-binding factor subunit beta homolog bro-1 homolog)
- Charged multivesicular body protein 4b
- Charged multivesicular body protein 4b
- Glycine Rich Secreted Protein
- ubiquitinyl hydrolase 1
- vesicle-fusing ATPase
- RING-type E3 ubiquitin transferase
- EF-hand domain-containing protein
Sequence:
MEALPIMPMLAPQSRSSTLSYDNIPNFDFRLRMKEYILLTFNADPHDYDSAFDELTQMKFEANVPTPSVEQTLKLKRYYGQLCMMQKRFPMGAGEQLETPFAWHDGLIDIRSAQSEVTICDIEFEKASVMFNIGACHAQYAAEQTRDTQDCIKAAFMHFQYAAYAFEQLNSFRNSDIFYPSVDLDANVISFYYKVMIAQAQECLVQKSLLDNRSAIVIAKLSLWLQEAYDSAAKIVDEWSVNIPESVQRYYAKICSLKSAMYAVIAYMSFGDNLEKEDKKMGWRLQYYNIANKYMELLSSNHSKMRERYPELFVTSSFLFDVISAKQRNAEKENDFIYHDRVPKQEDAIDAVQKDGGGAMCKVKTLSFDPLDPSVCGCDLFGKLLPTFVQDAVKKYSDDKDQALREIKECVRSYDEHLNYQLQLAEFDKLRFMLNEGKRSREAWFEISEDLMKRNADMTSYPDCVPNLIDKMGESSDTARVAEAKLNTLLSKLRAIDLQKSSIRSDEGFILIQKELERLAEHLEQAKAHNVSLNKAIAQHSANLQLLTLPCREMWMKIVPPEQQGEMRNGSSPEELQVRKMIEKVMEMQAQRRKLVEQFEADLKADNISNKLMGTNERGAEEIMKSELTKHTNIQQLIRLNITAQDAILRAFADANADFFEERLAMSTKKEEYEKRVSELCASYEVYRDVSKKVDEGEQFYRQLMARCDQFAIPVHAMEEQYREEMEKKERAKKEAEHHLNQIRMSRDAQNALMDFGGGRGGGAPGARAQQQAYQPSRGAAGAGAGAPRGPRLGDFMDSYRARKQAPQAQIPEDQGPPSPTPSSICDFPVQSQRSQRFGAFEGAQGAPGAQRGYQGPHSPVPGALTGSQASGPFGAPPGAPHGYGAPLQAPPQAPYGYDPSRYQDPSTYPAPPPILPGSAAYEHAIRPYPGDTGSYQVPRIVPGAQYGAQAGSGAYFGAQFGAQGAQGAHFGAQGVQFGAQGAQGAHFGAQGAQGAQFGAQGAQGEQFGAQGAQGAHFGAQGAQGAHFGAQGAQGTQFGAQGAQGPPPASYGAPTPPQASYGPAPGAHGYQNGAQGPPGAEVGAQGPPGAHFGAHGASAPPPTSYGAPTPQRPPQASYGAAPGAQGPPGGQFEAHGAAALPPTSHGAPTPQGPFGAAPGAQFGAQGPYGQQGARYEAQKSPGAAIFGAPGAPPQHQGSFGAQFGVPPPQNSAPGAQFGAKPEASSHAPTPPPQPHPSYQAPAPPPALSVFQHSPQGAPITAPPPASSHHEHIAAPQARFTPTPGAPSPWHATPAELKFQTPWNTTPQYHAPPGAQAAAPEAPAAPAPGAPAARSNVDLLSDLLGDFNLPPQPIQPTVHSTQQLQHQAPQQQEMSDFRIAAATLNPPPESVKPVKPAAAVQPMPQMTAQQVPAHGAQETPILKSSELSSSASTSSSITELSDPSKFQLGVGNVQKLEKRMLHQSFRNQGPPPPMNQSDPLNQIDAFSSFMTPRHQ
Protein: Importin subunit beta (Importin-90) (Karyopherin subunit beta) (p97) (P52297)
Organism: Xenopus laevis (African clawed frog)
Function: Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14974}. Nucleus envelope {ECO:0000250|UniProtKB:Q14974}.
Interaction partners:
Sequence:
MELVTILEKTVSPDRNELEAAQKFLEQAAVENLPTFVVELSKVLANPANSQVARVAAGLQIKNPLTSRDPDVKAQYQQRWLAIDASARGEIKTYVLRTLGTESYRPSSASQCVAGIACAEITVNQWPQLIPQLVANVTDPNSTERMKESTLEAIGYICQDIDPEQLQHKSNEILTAIIQGMRKEEPSNNVRLAATNALLNSLEFTKANFDKESERHYIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITVEAMKNEIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPESCQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAINDVYLAPLLQCLIEGLGAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPSSYCLSSSFEVIVQKLLETTDRPDGHQNNLRSAAYEALMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQVESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGAEFLKYMEAFKPFLTIGLKNYAEYQVCLAAVGLVGDLCRALQSNILPFCDEMMQFLLENLGNENVHRSVKPQILSVFGDVALAIGGEFKKYLDVVLNTLQQASQAQVDKSDYDMVDYLNELREGCIEAYTGIIQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDSVVACGAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKTKTLATWATKELRKLKNQA
Protein: Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Q13542)
Organism: Homo sapiens (Human)
Function: Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P70445}. Nucleus {ECO:0000250|UniProtKB:P70445}.
Interaction partners:
- Eukaryotic translation initiation factor 4E
- Regulatory-associated protein of mTOR
- Serine/threonine-protein kinase mTOR
- Eukaryotic translation initiation factor 4E-binding protein 1
- Eukaryotic translation initiation factor 4E-binding protein 3
- Ribosomal protein S6 kinase beta-1
- Eukaryotic translation initiation factor 4 gamma 1
Sequence:
MSSSAGSGHQPSQSRAIPTRTVAISDAAQLPHDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGTLIEDSKVEVNNLNNLNNHDRKHAVGDDAQFEMDI
Protein: Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form] (P28300)
Organism: Homo sapiens (Human)
Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:31152061}. Secreted, extracellular space.
Interaction partners:
- Elastin
- Fibulin-5
- EGF-containing fibulin-like extracellular matrix protein 2
- Fibronectin
- Fibrillin-1
- Microfibrillar-associated protein 2
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Collagen alpha-1
- Bone morphogenetic protein 1
- Polyunsaturated fatty acid lipoxygenase ALOX15B
Sequence:
MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
Protein: DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1) (Q969P6)
Organism: Homo sapiens (Human)
Function: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11526219}.
Interaction partners:
- DNA topoisomerase 2-beta
- DNA topoisomerase 2-alpha
- Tyrosyl-DNA phosphodiesterase 1
- Cellular tumor antigen p53
- DNA topoisomerase 3-alpha
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- Ribonuclease H2 subunit A
- RecQ-mediated genome instability protein 1
- Exonuclease 1
- ATP-dependent DNA helicase Q4
Sequence:
MRVVRLLRLRAALTLLGEVPRRPASRGVPGSRRTQKGSGARWEKEKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFFYEGRPVRLSVAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFEF
Protein: Suppressor of fused homolog (Q7ZVZ9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR011844}. Nucleus {ECO:0000256|PIRNR:PIRNR011844}.
Interaction partners:
Sequence:
MDEMRPSSGAAAHLGLASIFPPGLQAIYGECRRLYPDQANPLQVTAIVKYWLGGPDPLDYISMYRNAGCPGQDVPEHWHYVSLGLSDLYGDNRVHEFTGLEGPSGFGFELTFRLKREAGETAPPTWPAELMQGLARYVFQSENTFCSGDHISWHSPLDNSESRIQHMLLTEDPQMHPVQTPFGHVSFLQIVGVCTEELQAAQQWNGQGILDLLRGVHIAGGPWLITDMRRGESIFDIDPHLRQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDEDDSRSICIGAQPRRLSDKDTEQIREALRKGLEIKSKSILPPISGQRHSHDRPQQSVGHFQTQQISRSRKDSLESESSAAIVPHELVRTRQLESVHLKFNQESGTLIPMCLRGRLLHGRHFTFKSINGDTAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEQMLAEVQDLSTRDVCKLPKEYSWPDKKLKISVLPDTVFDSPLQ
Protein: Transcription factor MYB36 (Myb-related protein 36) (AtMYB36) (Q9FKL2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factors that activates genes required for endodermal differentiation but represses genes involved in proliferative divisions, thus regulating the transition from proliferation to differentiation in root endodermis. Required for Casparian strip formation by positively regulating the expression of the Casparian strip genes CASP1, PER64 and ESB1 and other endodermis-specific genes, thus triggering correct localized lignin biosynthesis in root endodermis and subsequently regulating global ion homeostasis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Casparian strip membrane protein 1
- Dirigent protein 10
- LRR receptor-like serine/threonine-protein kinase GSO1
- Peroxidase 64
- Casparian strip membrane protein 3
- Blue copper-binding protein-like
- Magnesium dechelatase SGR1, chloroplastic
- Transcription factor UPBEAT1
- Uclacyanin 1
- non-specific serine/threonine protein kinase
Sequence:
MGRAPCCDKANVKKGPWSPEEDVKLKDYIDKYGTGGNWIALPQKIGLKRCGKSCRLRWLNYLRPNIKHGGFSEEEDRIILSLYISIGSRWSIIAAQLPGRTDNDIKNYWNTKLKKKLLGRQKQMNRQDSITDSTENNLSNNNNNKSPQNLSNSALERLQLHMQLQNLQSPFSSFYNNPILWPKLHPLLQSTTTNQNPKLASQESFHPLGVNVDHQHNNTKLAQINNGASSLYSENVEQSQNPAHEFQPNFGFSQDLRLDNHNMDFMNRGVSKELFQVGNEFELTNGSSWWSEEVELERKTTSSSSWGSASVLDQTTEGMVMLQDYAQMSYHSV
Protein: Putative two-component response regulator-like APRR6 (Pseudo-response regulator 6) (Q9C9F6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Histidine-containing phosphotransfer protein
- Histidine-containing phosphotransfer protein 2
- Histidine-containing phosphotransfer protein 4
- Histidine-containing phosphotransfer protein 1
- Pseudo histidine-containing phosphotransfer protein 6
- Two-component response regulator ARR16
- Two-component response regulator ARR17
- Histidine-containing phosphotransfer protein 3
- Histidine-containing phosphotransfer protein 5
- Two-component response regulator ARR8
Sequence:
MAGCLVPECADDISILLIDHDTASIASLTSMLQQFSKRVMSVDVASKALSMIEKQKKEIGLIIANIEMPHIDSHSFLNALLLKDIPLILINPEIKTKEPSDLLTKRACFSLDKPISNDDIKNMWQHVFSKKSQELKKINITEDQENVMDKDTYQIEAFRANLKRQRISQASLLGRRPFIDTFSTYETFQKRKSIANVEWKTTPSYAIEIENKRKEWKKSVGRRKSLWNSERHMKFIAAISILGEEDFRPKSILEIMNDPNLTHRQVGSHLQKYKAQIDQISYTLPRNESRSIDKTFEYPSNYKYPFKISDLTNNLIVSNSLWNSLEKKNSASASITQFLFKKPIGEKEETMPKFHIGGKLDLSNHSVHGNVLNKLSMNVNFVPSTISNNPAYNILSIDSSSIDSSSYTGLVSTGLSSENSPILYGLPSNDGASNTCTSQMESERISIPQYDPNQCHPHRSILETDVNQIDLDFTSILDSFDPLVDECLMKENNRFLPNPTMNLLDTDIDKMDWVSFIENLSHHDINMNHMDWDPSTANYVLPETNMNINFPEKHTNEIGWVSSQVGYVPFENMIPSEVDINHMGMGYSGGSIPPQEETNTNNVGFVSCEIHSEIPPKTNMAILETNYSNPLDWVFPEDITSLETNTIQKSLVSCETSYDALDNMVPLETNMEEMNDALYDISIEDLISFDIDANEKDIFSWLEDNGFSEENNMMESCEYHNIESVNQSDDMKIDDNFDDYRECMDWINEEMNKDV
Protein: Palmitoyltransferase (EC 2.3.1.225) (E1JIY0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MCIVNDWCREYANLYPKKAVSIGHPLSVIFLLFFVISAIFTTYNILGNLLACYRTSSAVKSLPQERQIPKPGTEHLWHYCDICQKLMPPRSWHCALCKCCILKRDHHCIFAATCIGHNNHRYFFWLTFYLAFGIFMSMATLFVDVGRSFYLLHRMKAGFGNTVKSLSYFRYVCLILNIFALGFPALMLRFQVQILKLNSTYYQISSRHHDLGFRNNCQLIMGQRGLWTFISPSLRSPLPHDGTHWKIKQCF