wanglab/gogpt-training-data huggingface dataset:
Protein: 14-3-3-like protein G-BOX factor 14 lambda (14-3-3-like protein GF14 lambda) (14-3-3lambda) (14-3-3-like protein AFT1) (14-3-3-like protein RCI2) (General regulatory factor 6) (P48349)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes (By similarity). Specific negative regulator of slow-vacuolar (SV) ion channel. Mediates F-actin dynamics possibly through inhibiting ADF1 phosphorylation. Negative regulator of freezing tolerance that modulates cold-responsive C-repeat-binding factors (CBF) DREB1A and DREB1B proteins stability by facilitating their ubiquitin-mediated degradation when activated by CRPK1-mediated phosophorylation in freezing conditions.
Subcellular location: Nucleus {ECO:0000269|PubMed:15592873, ECO:0000269|PubMed:28344081}. Cell membrane {ECO:0000269|PubMed:15592873}. Cytoplasm {ECO:0000269|PubMed:28344081}. Note=Translocates from the cytosol to the nucleus when phosphorylated by CRPK1 in response to cold stress. {ECO:0000269|PubMed:28344081}.
Interaction partners:
- Hydrophobic protein RCI2A
- Monothiol glutaredoxin-S17
- Protein BOLA1
- Monothiol glutaredoxin-S14, chloroplastic
- Probable E3 ubiquitin-protein ligase RHC2A
- Monothiol glutaredoxin-S15, mitochondrial
- Dual specificity phosphatase Cdc25
- NifU-like protein 1, chloroplastic
- NifU-like protein 5, mitochondrial
- Bifunctional monothiol glutaredoxin-S16, chloroplastic
Sequence:
MAATLGRDQYVYMAKLAEQAERYEEMVQFMEQLVTGATPAEELTVEERNLLSVAYKNVIGSLRAAWRIVSSIEQKEESRKNDEHVSLVKDYRSKVESELSSVCSGILKLLDSHLIPSAGASESKVFYLKMKGDYHRYMAEFKSGDERKTAAEDTMLAYKAAQDIAAADMAPTHPIRLGLALNFSVFYYEILNSSDKACNMAKQAFEEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQEQMDEA
Protein: TU4 isoform A (B2M0R4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MSQAPKPQLPGNTEDPNCGTHPEPSQLFSDDDQVIVCSKCFQSPEHKQHGAYGIQEAAEYYRMLLQETLVTLREKRDAATSLLAEERERMVTIQEEEQRFKEMIEAEYKMRFQLLTEEEELAAYKVDLNLNGPNPDQLMKCGTELMQKSQEMLQRLSHLGRENMEKLKASEVRLGEHLRSLQTMITDLEKNCGESAVALLQNAKCYLKRNESILLQSLEPAQITDLSSCQIIETSRVLLRLQRHITLDPGTAHPSLVLSEDLRGVGFRETPKTGPGTTRRLDFGASVLGAESFTTGRHYWEVAVGQATQWQVGICDCTERKGNIPGASGDKVLLMGSMMGTDCTLWVFPPLRKVCLRNQMYKVGVFLDCECGQVSFYNVTEQSLIYSFSDLTFRGAVKPIFSLCIPNGGMSSDSLTVCLSQTHP
Protein: U3 small nucleolar RNA-associated protein 15 homolog (Q8TED0)
Organism: Homo sapiens (Human)
Function: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24219289, ECO:0000269|PubMed:34516797}. Note=Found predominantly at the fibrillar center. {ECO:0000269|PubMed:24219289}.
Interaction partners:
- WD repeat-containing protein 36
- Transducin beta-like protein 3
- Ribosome biogenesis protein BMS1 homolog
- NHP2-like protein 1
- U3 small nucleolar RNA-interacting protein 2
- U3 small nucleolar RNA-associated protein 18 homolog
- WD repeat-containing protein 3
- U3 small nucleolar ribonucleoprotein protein MPP10
- WD repeat-containing protein 43
- U3 small nucleolar RNA-associated protein 4 homolog
Sequence:
MAGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKNYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTCTIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDMLFATMRRKEGTSVLEHTSDGFPENKKIES
Protein: Pore and endoplasmic reticulum protein of 33 kDa (Q12144)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus, nuclear pore complex.
Interaction partners:
- Reticulon-like protein 1
- Protein SEY1
- Tyrosine--tRNA ligase, cytoplasmic
Sequence:
MTVPRNRPMAPFGTIIKSRIKQPQFYWFIGHFLTIFNFIQFHLSITSKQNQLSCYRRSLFYISVTYAIVLYQFFKSDQLKFNFTLLRQEMKKLDNLQYFAMLFILFLLSQFNIIISGSLYSPVIFSIFHFLNYFKENLLPFLPLIPLNLKNLLNSKITVFIQNYNGFFLQMAQVFEIICGLRVGLFLVPFNFFLLLVRRANVSFEVVGTMLAGLTYVWFFKLRYLQSESMRQIFKQYVLRLDAYVSRTLPPYCSRLWNGYKNFVMTVFWKIPV
Protein: Protein TIFY 10b (OsTIFY10b) (Jasmonate ZIM domain-containing protein 7) (OsJAZ7) (OsJAZ6) (Q8H395)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Repressor of jasmonate responses.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Coronatine-insensitive protein homolog 1b
- Coronatine-insensitive protein homolog 1a
- Transcription factor MYC2
- Os10g0506950 protein
- Coronatine-insensitive protein homolog 2
- Protein TIFY 9
- Protein TIFY 3
Sequence:
MAASARPVGVGGERATSFAMACSLLSRYVRQNGAAAAELGLGIRGEGEAPRAAPATMSLLPGEAERKKETMELFPQSAGFGQQDAITADSAADAREQEPEKRQLTIFYGGKVLVFNDFPADKAKGLMQLASKGSPVAPQNAAAPAPAAVTDNTKAPMAVPAPVSSLPTAQADAQKPARANASDMPIARKASLHRFLEKRKDRLNAKTPYQASPSDATPVKKEPESQPWLGLGPNAVVKPIERGQ
Protein: Platelet-activating factor acetylhydrolase (EC 3.1.1.47) (A0A8I6GE94)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239}.
Interaction partners:
Sequence:
MEDQRVMFHKLQSVMSAVSAGRCKIPKGNGSYPVGCTDMMFGYGNESIFLRLYYPAQDQGPHDTVWVPNIEYFWGLSKFLGTPTFVGNILRLLYGSLTAPASWNFPLRTGEKYPLIIFSHGLGAFRTIYSAIGAALASYGFIVATVEHRDGSASATYYFEDQAAAKMENRSWFYLKKIKQEESERARKEQVRQRAKECSKALSAILDIEHGNPKENVLGLPFDMKQLKDSIDETKIAVMGHSFGGATVFQALSEDQRFRCGIALDPWMFPVSEELYSRVPQPLFFINSAEFQTPKDIAKMKNFYQPDKERKMITIKGSVHQNFADGTFVTGKIIGNKLSLKGDIDSRVAIDLTNKASLAFLQKHLGLHKDFDQWDCLVEGENENLIPGSPFDVVTQSPALQSSPGSHNQN
Protein: Protein SHORT INTERNODES (Q9XGX0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that binds DNA on 5'-ACTCTAC-3' and promotes auxin homeostasis-regulating gene expression (e.g. YUC genes), as well as genes affecting stamen development, cell expansion and timing of flowering. Synergistically with other SHI-related proteins, regulates gynoecium, stamen and leaf development in a dose-dependent manner, controlling apical-basal patterning. Promotes style and stigma formation, and influences vascular development during gynoecium development. May also have a role in the formation and/or maintenance of the shoot apical meristem (SAM). Suppressor of the gibberellin (GA) signal transduction.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Probable indole-3-pyruvate monooxygenase YUCCA4
- Probable indole-3-pyruvate monooxygenase YUCCA1
- B3 domain-containing transcription factor NGA3
- Electron carrier/iron ion-binding protein
- RNA-binding KH domain-containing protein RCF3
Sequence:
MAGFFSLGHGGGGNTPDNHRTNTNNPSSSGTESWLWCRNPNSNADGGEAGPSYKGTLELWQHPNNQEIIFQQQQQQQQRLDLYTSAAGLGVGPSNRSLIETSGGALMMMRSGSGSGGPSCQDCGNQSKKDCSHMRCRTCCKSRGLDCPTHVKSTWVPAAKRRERQQQLSTGQQPQQLGGSVPKRQRERIPARSTSMAYTRIPSNNTSGLEVGNFPPEVSSSAVFRCVRVSSVDDEEEEYAYKTAVSIGGHVFKGVLYDQGPAERSSSGGGSQPLNLITAGPSASSSSPNVSCNNGVVGSTSDHYIDPASLNYPTPINTFMTGTHFFSNSRS
Protein: Peroxisomal membrane protein PEX13 (Peroxin-13) (Q19951)
Organism: Caenorhabditis elegans
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5/prx-5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5/prx-5 receptor along with cargo proteins associates with the PEX14/prx-14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (By similarity).
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:Q92968}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisomal membrane protein PEX14
- Putative peroxisomal biogenesis factor 19
- Peroxisome assembly protein 12
- TPR_REGION domain-containing protein
- Peroxisomal biogenesis factor 11
- Peroxisomal ATPase PEX1
- Peroxisomal ATPase PEX1
- Peroxisomal biogenesis factor 3
- RING-type E3 ubiquitin transferase
- Acyl-coenzyme A oxidase acox-1.1
Sequence:
MSAPPTNQPPPLPPRSFDNQMSNPMINTGFGYGGGYGMNTFPGSGMYGGGGMYGGGMGYGGFGGGFNHMGYGQGPDSNFARLAEEQSRGAFQSIESVVNAVSSVANMLNSTHNAVYSSFRAVIGVVEQFGRLKTQLSSVVVSLAVFRWVYRFWRWLLVMLKLKPASYASAAEMAWGTSQPYATDVLGATRTPASVNWPAALFWVVAIGGPWLIYRCVSQMVQAAEEKRKWATGAAPHYTAQALFDFQASNEQELSFMNGETLRVAPKEEQPRVRGWLLASVADGSRIGLVPINYVRIVGKQSQSPPLTQQSNLDTFVNAFPARDLNSNIQ
Protein: GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) (Q99L27)
Organism: Mus musculus (Mouse)
Function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity).
Interaction partners:
- GMP synthase
- Adenylosuccinate synthetase isozyme 2
- Adenylosuccinate synthetase isozyme 1
- Bifunctional purine biosynthesis protein ATIC
- Adenine phosphoribosyltransferase
- Inosine triphosphate pyrophosphatase
- Hypoxanthine-guanine phosphoribosyltransferase
- GMP reductase 1
- AMP deaminase 1
- Inosine-5'-monophosphate dehydrogenase 2
Sequence:
MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVELTRSFSFRNSKQMYSGIPVIAANMDTVGTFEMARVLCKFSLFTAIHKHYSIHQWQEFASQNPDCLECLAASSGSGSADFEQLEQILEAIPQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYSGGVAEYRASEGKIVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQQVNPIFSNSQ
Protein: DNA-binding protein SATB (Special AT-rich sequence-binding protein) (C9JR56)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MERRSESPCLRDSPDRRSGSPDVKGPPPVKVARLEQNGSPMGARGRPNGAVAKAVGGIIKLGRWNPLPLSYVTDAPDATVADMLQDVYHVVTLKIQLQSCSKLEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIKVERVERENLSDYCVLGQRPMHLPNMNQLASLGKTNEQSPHSQIHHSTPIRNQVPALQPIMSPGLLSPQLSPQLVRQQIAMAHLINQQIAVSRLLAHQHPQAINQQFLNHPPIPRAVKPEPTNSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKEEDPRTASQSLLVNLRAMQNFLNLPEVERDRIYQDERERSMNPNVSMVSSASSSPSSSRTPQAKTSTPTTDLPIKVDGANINITAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRWKENPSPENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREEAPPPPPPTEDSCAKKPRSRTKISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEEMYKVEAEEENADKSKAAPAEIDQR
Protein: Interferon alpha-17 (IFN-alpha-17) (Interferon alpha-88) (Interferon alpha-I') (LeIF I) (Interferon alpha-T) (P01571)
Organism: Homo sapiens (Human)
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular location: Secreted.
Interaction partners:
- Interferon alpha-16
- Interferon alpha-10
- Interferon alpha/beta receptor 1
- Interferon alpha/beta receptor 2
- Interferon regulatory factor 7
- Interferon gamma
- Interferon gamma receptor 1
- Interferon regulatory factor 3
- Signal transducer and activator of transcription 1-alpha/beta
- Tyrosine-protein kinase JAK1
Sequence:
MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFGLPQEEFDGNQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNNLEACVIQEVGMEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTNLQKILRRKD
Protein: Uncharacterized protein B0303.7 (P34258)
Organism: Caenorhabditis elegans
Interaction partners:
- GTP cyclohydrolase 1
- SH3 domain-containing protein
- Unconventional myosin-Ie
- Endophilin-A homolog
Sequence:
MVRLPPPTPPRKPNICGTSGNSNGINENIDTSTFSVSAAKALFESAKRPEVRNAAIAAAKNPFVRQTAKNVAQDEKARGAVLNAVKDPSGGNKISAAFAVADANRKSDSVPPPPPHRGGTSPGKLSGSHSAIRSQLENMHIGGSVMSSNSSTATPSYQSNSTSSYSSSAPVAPPPVPRHTQSIPSYSAPAISTPYGIAKFDYAPTQSDEMGLRIGDTVLISKKVDAEWFYGENQNQRTFGIVPSSYLDIKIPLKEAFTALPPRPAAPSGSSSGTYATAIYDYNSNEAGDLNFAVGSQIMVTARVNEEWLEGECFGRSGIFPSQFVDCPNLYQVPMKQSAPSSAPSYSHPITNNSGPKQTVTVSYDYDSGVASDLRLFEGDVITALEDIDAQWLLAECRGQQGMVPKTFLGPPYGSPKKAPSKGIAEIACAFSPKKAVATGDYHSEDPKHLYVTRGDHLLIVEDVDDYYYKGKLEAFKTLPAGILPKNIVKLEN
Protein: Pre-rRNA-processing protein ipi1 (O94718)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P38803}.
Interaction partners:
- Pre-rRNA-processing protein crb3/ipi3
- Pre-rRNA-processing protein rix1
- Nucleolar GTP-binding protein 2
- Pescadillo homolog
- Probable nucleolar GTP-binding protein 1
- GTPase grn1
- Zinc finger protein bud20
- Nucleolar complex-associated protein 3
- Polynucleotide 5'-hydroxyl-kinase grc3
- Eukaryotic translation initiation factor 6
Sequence:
MGKSKKAKAKRADFNKQKLKVGKSKNAPNNFTDTSFRTKTLVLPTQAALEKEDFNTTAKDQAYFAHLLGMLKHHNANQRQETLEKLTQYVLSHTSILTTSTALLLKLTSPLILDESSSVRDCLYRFLEKFIYIMGPELLEPNIGMIFLYTHSGMTHITPSIRNDSTKFLSLLINACKDRLSSSAISLQWKKTLECFTNLLGWNSESASVKRTTSFSKKSSANMIRHLTVCNDFLQLGLNPKLQAKNQQSSVHLKYPYLQQCIVIHPKYEAFRSPCSFAYLSLFNPNKHDLVDNPTFRWQTIYPLIPGIIEFIRNSWSDACPVVKDGSNSPSASKVCRTVLSMLGLFTEQVFSVADEPNNHRKKISQVLRKINRDIELININYGTDSEWRGVLKGYDKLRERAVELDALENPGK
Protein: Ras-like protein rasD (EC 3.6.5.2) (Transforming protein p23 homolog) (P03967)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Ras guanine nucleotide exchange factor C
- Cyclic GMP-binding protein C
- Ras GTPase-activating-like protein rgaA
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Ras guanine nucleotide exchange factor S
- Serine/threonine-protein kinase phg2
- Extracellular signal-regulated kinase 2
- Protein kinase 2
- Ras guanine nucleotide exchange factor A
- Probable serine/threonine-protein kinase roco5
Sequence:
MTEYKLVIVGGGGVGKSALTIQLIQNHFIDEYDPTIEDSYRKQVSIDDETCLLDILDTAGQEEYSAMRDQYMRTGQGFLCVYSITSRSSYDEIASFREQILRVKDKDRVPLILVGNKADLDHERQVSVNEGQELAKGFNCPFMESSAKSRINVEEAFYSLVREIRKELKGDQSSGKAQKKKKQCLIL
Protein: Heme uptake outer membrane receptor HasR (Q9HYJ7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004571, ECO:0000256|PROSITE-ProRule:PRU01360}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004571, ECO:0000256|PROSITE-ProRule:PRU01360}.
Interaction partners:
- Heme acquisition protein HasAp
- Transport protein HasD
- Heme oxygenase PigA
- Probable transmembrane sensor
- Ferric enterobactin receptor
- Protein TonB
- Biopolymer transport protein ExbD
- Hemin import ATP-binding protein HmuV
- Sigma factor PvdS
Sequence:
MKHRGWSAVRGGRKGAQLALGLGLVLLGTAALPLHAQDGADSASQQQTALRRVRLDIPAQPLNRALLRFAEQAGVQVFFDSQRFAGLGSAAVHGEYLLADGLSQMLQGSPVEYRFSGKDQLSLIRVSQDDLVQMSPSVISAARPDDWVYQTPHSVSVIGREQIERNPPRHAADMLEETPGVYSSVSQQDPGLSVNIRGIQDYGRVNMSVDGMRQNYQQSGHQQRNGTLYVDPELLSEVVIDKGASSAMGGAGVIGGIANFRTLEARDLVRPGKQVGGRVRLTSGLGGDANGTHFIGSAAFAIGTEVWDMLVAASERHLGDYDPGTKGSIGELRTGAWFNPEAGQRVKHSPVAYSGYVMRSRLAKLGVALPQDQRLQFSYLTTQVSYDDANMLNTENQALWEKLGSSDVRAQNFAIDYGYAPDNPLVDFKAKLYYVDNRNRQQTLQRGITPGYSITYQTDTYGAQAQNTSTFALDDLSTLRANYGLEFFYDKVRPDSSQPRASTSAVGFPAAEGMTPKGDRALGSLFARLDYDYDDWLNLNAGLRYDRYRLRGDTGFNARTFILGTTRQTDMPLQYAVDREEGRFSPTFGLSVKPGVDWLQLFATYGKGWRPPAVTESLITGRPHGGGAENMYPNPFLSPERSKAWEVGFNVLKENLWFSDDRLGLKVAYFDTRVDDFIFMGMGMQPPGYGMAGIGNSAYVNNLDSTRFRGVEYQLDYDAGLAYGQLSYTHMIGSNDFCSKTAWLGGVTQTVKGSGRRPPVIDMRPDEQANAATHCSAVLGSAEHMPMDRGSLTLGMRFFDRRLDVGARARYSEGYSVAGGATVSQAGVYPADWKEYTVYDLYGSYRVSDELTLRLAMENVTDRAYLVPLGDVLAFTLGRGRTLQGTLEYQF
Protein: Akirin-2 (Q53H80)
Organism: Homo sapiens (Human)
Function: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development. Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore. Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:18066067, ECO:0000269|PubMed:34711951}. Cytoplasm {ECO:0000250|UniProtKB:B1AXD8}. Membrane {ECO:0000250|UniProtKB:B1AXD8}. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. {ECO:0000250|UniProtKB:B1AXD8}.
Interaction partners:
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-1
- NF-kappa-B inhibitor zeta
- Proteasome subunit alpha type-6
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-7
- Proteasome subunit beta type-2
- Proteasome subunit beta type-3
- Proteasome subunit beta type-1
Sequence:
MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPTSAAASPLSAAAATAASFSAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLETSFQQTDPCCTSDAQPHAFLLSGPASPGTSSAASSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS
Protein: phosphatidylserine decarboxylase (EC 4.1.1.65) (Q38DZ5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Phosphatidyl serine synthase, putative
- Ethanolaminephosphotransferase, putative
- Choline dehydrogenase, putative
Sequence:
MASLTRQLRFYKNDTTRPFTNPMRRWLYHYLFGGAIIGGAVYVGGRYQLAAWEATRHPEGGTRLCSVGMLEMLMLFPFNYISHICGRISENECLPSSFHRAVIAAIIWWYGMDAPRGKEREYKTLQEFFVRRWEDGERRVATSPVVMPSDGVVLSVQEDVVDDQLLQVKGVTYSVRRLFHSPLGTVAEGNRRIAVALHLRTQDYHHVVTPCLFTCKEVVYIPGALLPHTPAGYHWIPSVLPLNERVVLLGSWTDEHSASGNMGLALVGGTLTGRIVLHLDQRIKTNFLAPPEYAVHRCYSRAATSKKGDLLSTFYWGSSVVLVLDIPKTASVAVKPGDIVKAGEALVTYGLSESGK
Protein: NFKB inhibitor zeta (C9JZ23)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQ
Protein: Mitochondrial membrane-anchored protein domain-containing protein (Q57ZY0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Cytochrome c oxidase assembly protein
- Ubiquinol-cytochrome c reductase complex 14 kDa protein
Sequence:
MLRRTRFICVGAKHFFRTDGQPYQPYTIKSLFLFGFIASTAFLSVFTVKETKKAGPLELPDELEDERRRRNDPRRPPWPLLHQRSVLLREGKAPHDDLLLLWEQTRHYYPADWLVPLEITQVLKYTSGAYLQNYVPDPDQLRKEVLMQLLNIQYGRVRDPNGGRLNRDVKEIIAMAIEDLENMDLSPGTEPALVPTHT
Protein: Uncharacterized protein (Q57WV3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRRSVPSLYSTIVAPIGKGRVVPLNFSGPKPVYQPKSFVTQFNVLGMWTISNMIPNFIFGALLIAGAHGGLAGAWPPDPHSLHP
Protein: Tlo13p (A0A1D8PPA9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Tlo1p
- Cta24p
- Tlo9p
- Cta2p
- Tlo4p
Sequence:
MPENLQTRLHNSLDEILKSSGYIFEIIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLDDAEWCLGVMVEKKKKLDELKVKEEAARKKEEEAKKEEEXKKAEEAKKCFILLFCQICTTFNLCANILFYLIFIYFYFTILFYRTFYIFSLSTHLLYNIFLRL
Protein: Kinetochore-associated protein NSL1 (Q12143)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules. NSL1 facilitates the attachment of two of the DASH complex components, DAD2 and SPC19, to the kinetochore in a microtubule-dependent manner.
Subcellular location: Nucleus {ECO:0000269|PubMed:12455957, ECO:0000269|PubMed:14657030}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12455957, ECO:0000269|PubMed:14657030}. Note=Associated with the kinetochore (PubMed:12455957, PubMed:14657030).
Interaction partners:
- Kinetochore-associated protein MTW1
- Kinetochore-associated protein DSN1
- Kinetochore-associated protein NNF1
- Outer kinetochore KNL1 complex subunit SPC105
- Inner kinetochore subunit AME1
- Kinetochore protein SPC24
- Inner kinetochore subunit OKP1
- Kinetochore protein SPC25
- Inner kinetochore subunit CTF19
- Outer kinetochore KNL1 complex subunit KRE28
Sequence:
MSQGQSKKLDVTVEQLRSIYHQFHDILEEKTDLHLPKKEYDDDAVRREVQIQLQEFLLSAMTMASKSLEVVNADTVGKTVKQLIMESQEKYMEPFDLDLNEQVRKMYQEWEDETVKVAQLRQTGPAKINEVYNNSKDEYLAQLDGRIGVLQARMMQQQSADHDDSTDDADDHINWEHIKQDYVASLNELYQTQQDLPKVRYNVEKVKRLMDFLEED
Protein: Arabinose kinase-like protein (Mevalonate/galactokinase family protein) (Q9M1M0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSESESSSSPRSSLVFAYYVTGHGFGHATRVVEVVRYLISSGHRVHVVSAAPEFVFTMEIHSPNLFIRKVLLDCGSVQADALSVDRRASLEKYCEIAVEPRDSILATEAEWLKSIKANLVVSDVVPIACRAAANAGIRSVCVTNFSWDFIYAEYVMAAGHHHRSIVWQIAEDYSHCEFLIRLPGYCPMPAFHDVIDIPLVVRPVHKSGQEVRRELGVPDNVKLLIFNFGGQPTGWTLKEEYLPAGWLCLVCGASAKQELPPNFIALPKDAYTPDVIAASDCMLGKIGYGTVSEALAYKLRFIFVRRDYFNEEPFLRKMLEYYQGGVEMIRRDLLAGCWAPYLERAVTLKPCYDGGIDGGEVAAKILQDTAMGKKRSKLNLSGARRLRDAIILGFQLQRAPGRDLSVPEWYQVAGNEAGIPSVDQTQKPSKFVEGFEILHGDHHGLSDTIGFLDSLATLAKIGGHHQEREHLAAAALFNWEEDIVVARAPGRLDVMGGIADYSGSLVLLMPTREACHAAVQRNHPSKQKLWKHAEARHHSRDTPILEIVSFGSELSNRGPTFDMDLSDFMEEDGKPISYDKAYHYFSRDPSQKWAAYVAGTILVLMREMDVRFEDSISILVSSTVPEGKGVSSSASVEVATMSAVAAAHGLEISPRDVALLCQKVENYVVGAPCGVMDQMASACGEANKLLAMICQPAEILGLVEIPSHIRFWGIDSGIRHSVGGSDYGSVRIGAFIGKTMIRSFAASFAETNSEEAEEESSELIESDTSLDYLCNLSPHRFQALYASKLPQSITGEEFLEKYGDHGDSVTTIDKDGTYAIMAPTRHPIYENFRVQAFKALLTATPSEEQVIGLGELMYQCHDSYSACGIGSDGTDRLVRLVQNMENLKSSKTENGTLYGAKITGGGSGGTVCVIGKSSLRSSEQILQIQQKYKEATGFMPYVFEGSSPGAGKFGYLKIRKNSAT
Protein: Endo-1,4-beta-xylanase 4 (Xylanase 4) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase 4) (Q12550)
Organism: Aspergillus niger
Function: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MKVTAAFAGLLVTAFAPPVPEPVLVSRSAGINYVQNYNGNLGDFTYDESAGTFSMYWEDGVSSDFVVGLGWTTGSSNAITYSAEYSASGSSSYLAVYGWVNLSQAEYYIVEDYGDYNPCSSATSLGTEYSDGSTYQVCTDTRTNEPSITGTSTFTQYFSVRESTRTSGTVTVAIHFNFWAQHGFGNSDFNYQVMAVEAWSGACSASVTISS