wanglab/gogpt-training-data huggingface dataset:
Protein: GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) (Q6PAR5)
Organism: Mus musculus (Mouse)
Function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.
Subcellular location: Membrane {ECO:0000269|PubMed:17189207}; Peripheral membrane protein {ECO:0000269|PubMed:17189207}. Endosome {ECO:0000250}. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.
Interaction partners:
- Ras-related protein Rab-31
- Rab GTPase-binding effector protein 1
- Ras and Rab interactor 1
- Alsin
- Rab5 GDP/GTP exchange factor
- Rabankyrin-5
- Ras-related protein Rab-5B
- Ras-related protein Rab-5C
- Ras-related protein Rab-5A
- ALS2 C-terminal-like protein
Sequence:
MVKLDIHTLAHHLKQERLYVSSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPAQQEKLFGEKGSDRFRQKVQEMVDSNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGTEEGDPRTKNSLGKFDKGCVAAFLDVVIGGRAVETPPMSSVNLLEGLSRTVVYISYSQLITLVNFMKSVMSGDQLKEDRMALDNLLANLPQAKPGKSSSLDMTPYSTPQMSPATTPANKKNRLPIATRSRSRSNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNVDEDRLQEIAGAAAENVLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDDIAHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTAAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEELPPAAATGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDERSDRSRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDEPSPRLSAQAQVAEDILDKYRNAIKRTSPSEGAMANDESAEVMGDGESAHDSPREEALQNISADDLPDSASQAAHPQDSAFSYRDVKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKSLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGVMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
Protein: Pre-mRNA-splicing factor 38 (Q59WJ8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367025}.
Interaction partners:
- Micro-fibrillar-associated protein 1 C-terminal domain-containing protein
- U4/U6-U5 snRNP complex subunit
- Ubiquitin-like modifier HUB1
- U4/U6-U5 snRNP complex subunit
- U4/U6-U5 snRNP complex subunit
- U1 small nuclear ribonucleoprotein component SNU71
- SF3a splicing factor complex subunit
- Pre-mRNA-splicing factor PRP46
- Pre-mRNA-processing factor 17
- U2 snRNP complex subunit
Sequence:
MTENTTPYYKKQASYQDKRYTINKSNLIEPIIRHRIQDSLFYKQHLYLSNEATILPIIIEHVHYIGGTDSSNRPSTFISCLFRLLELEPSKEIIKTYLTQLDFNEFKYLTALTLIYIRLTYPSQEVYSIFDQYFQDFRKLRIKLKTPVFDSQKLPIHYKITFIDEWVDTLLVNERVIDLMLPRLIPRTTLVERGQLAPRQYYIDVSDEEEKDAGEEEKDAGEEEDNDYESDSD
Protein: ATCAY kinesin light chain-interacting caytaxin a (Caytaxin isoform X2) (F6NPA8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDSSCALSDGRTSPPNSLLIGGAGGGGAHRKRRTLVAPDMNLSLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFITNGNDLEWEDDTPVASAKAPPADSDADGEGVDGTGANGRLWRTVIIGEQEHRIDMQVIRPYLRVISHGGYYGEGLNAIIVFTACYLPDSSCPDYHYLMENLFLYVVSSLEMLVAEDYLIIYMNGGTPRSKMPGISWLKKCYQMIDRRLRKNLKSLIITHPSWFIRTVIAISKPFISVKFMNKIRYVHSLEELEKFVPMDHIHIPECILQYEEERLNARKERMEQEQKEQQHQEQQQKPTNPERTTAIEEPGL
Protein: Proteasome subunit alpha type (H0YLC2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Interaction partners:
Sequence:
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAWKLQH
Protein: GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Glycosylphosphatidylinositol-anchor biosynthesis protein 13) (O13663)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Involved in cell wall biosynthesis (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- GPI mannosyltransferase 3
- GPI transamidase component gaa1
- GPI-anchor transamidase
- GPI transamidase component PIG-T homolog
- GPI transamidase component GAB1 homolog
- GPI mannosyltransferase 4
- Alpha-1,2-mannosyltransferase alg9
- Probable Dol-P-Man:Man
Sequence:
MEEKRVKCKKKLTSTIGTWKYIQACIFFAIILISNFYGLKSFTDGFLLRRAVLNQTSLCENPPADVREWKNSSGCWAPKIFERAVIVIIDALRYDFLIPYNDSNYYHNAFTTPYETSVLHPENSYLTQFIADAPTTTSQRLKGLTTGSLPTFIDLGSNFAGTNIDEDNLLLQWKSLDKQIVLLGDDTWDVLFHDYLNETLSQPAFSFNVPDLHGVDNKVNQYVFDYIKDANFDVLIAHYLGVDHVGHRLGPDHPTMRDKLNQMDRCVKEMMDLLDDSTLLIVMGDHGMDNKGNHGGDSFDEINSVLWMYSKKPTFGYLKQPGKVLSANQVDLVPTLSLLLGNPIPYGNLGTLIPEPFYYYGDEYLSKAQKINIGQLNRFFSEYDLDASDFLSSSVHKNNNSYLDQYFLDFDYARDAFSYFKAIWAEFSLFPMIIGFLLLIIGGFNLALLMQDKSVIFRMSANMAPSVMKCLPVCLILILANNELHSPFPAEFYVLLPSFYILLNSFNQKLMEYFKGFVKLDYFSIFITFLHVCSFGSNSFTVWEDRLCHFLIITIGLVMFCKCFSEMSPLFACSTYSALAFILLQVISSYVTNCREEQGAFCVSTYISTPDNSLRTLIVLALMALSSIILPLILQLHLRRVLGLSLKLYHLSILYFFELISSIFWIAHHVFANDALLEKQYHHVLYSLANTYVICILGVLIWQFFLLSRSKFAKINVIERSYFVFALLYSFLSFLQRPLGHLSLFSCFLQILLLIQLKQWQPSVGHNFFSVTLGLLGLSHFFTTGNQAAISSLDWNFAFIHSKSAENQAISAIFMFLHTVGAPILTCISIPLFSFEPLSKKNRFLINLFRFSFSFILYNLLISTSTVFFAGFFRRHLMVWKVFAPRFMLSGILLVTHQLFVLIQCFGSSVVKFPEDAE
Protein: SWI/SNF chromatin-remodeling accessory subunit 2 (O02101)
Organism: Caenorhabditis elegans
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Probably regulates vulva development through the let-60/Ras pathway. Involved in nuclear reassembly after mitosis and recruitment of nuclear envelope protein, mel-28, to the nuclear periphery in the early embryo and in the adult germline. Involved in gonadogenesis.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:26739451}. Chromosome {ECO:0000269|PubMed:26739451}. Nucleus envelope {ECO:0000269|PubMed:26739451}. Note=Localizes to mitotic chromosomes in the early embryo. {ECO:0000269|PubMed:26739451}.
Interaction partners:
- SWI/SNF complex subunit SMARCC2
- Actin-related protein 4
- HMG box domain-containing protein
- SWI/SNF Subunit INI1 DNA binding domain-containing protein
- SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4
- Bromo domain-containing protein
- PHD finger protein 10
- ARID domain-containing protein
- SWI/SNF chromatin remodeling complex subunit swsn-7
- Zinc finger protein dpff-1
Sequence:
MHSQQRPNPQMNRHPYGTPGSAPQMRRPGGFAGQPPQMHGPRMVAPPAAPLPKKKKYADKCIHPKIRELEPDAENYMALLASEQKLDSTLSRKKLDIQEALKRPSKVKKRLRIYISHTFIEEKQPEKDTDEASLPMWELRVEGRLLDEQPPAPAIPGQRPVPKRKFSSFFKSLVIELDKEMYGPDQHLVEWHRTPQTNETDGFQVKRAGDRPVKCRILLLLDNHPAKFKLHPRLAKVLGIATETRPKIIEALWQYIKTHGLQDPQERDIINCDTFLSQCFGVNRMRFMEVPNKLHQLLQQTDPLEFNHIIQRPKEGQEQVSTCYDIDVEMEDPVKQFMHTFVHSPGLANDIQTLDQKCYDIIEQINELKTRRDFYARFYTEPAEFIKSWVMSQNSDLKTMNELSGDLEAERFAESYVRPETEEGVQRYMFQKVNQKRHELEQSLGVRSN
Protein: Nuclear envelope integral membrane protein 1 (Q6ZQE4)
Organism: Mus musculus (Mouse)
Function: Together with EMD, contributes to nuclear envelope stiffness in germ cells. Required for female fertility.
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:25946333}; Multi-pass membrane protein {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}. Nucleus envelope {ECO:0000269|PubMed:25946333, ECO:0000269|PubMed:36215313}. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. {ECO:0000269|PubMed:25946333}.
Interaction partners:
Sequence:
MAGGIKVSVWSAVGPGPRCWGAGGGGGATWLLLVVAGCVVCGSADVNVVMLQESQVDMNSSQQFCYKNVLIPKWHDIWTRIQVRVNSSKLVRVTQVDNEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEMIEKDTTYSVTVTRRFDPKLFLVFLLGLTLFFCGDLLSRSQIFYYSTGMSVGIVASLLIVIFMISKFMPKRSPIYVILVGGWSFSLYLIQLVFKNLQEIWRSYWHYLLSYILTVGFMSFAVCYKYGPLENERSINLLTWTLQLLGLGLMYSSIQIPHVAFALIVIALCTKNLEYPIHWLCSTYRRMCKASGKPVPPRLLTEEEYRIQGEVETQKALQELREFCNSPECSAWKTISRIQSPKRFADFVEGSFHLTPNEVSVHEQEYGLGSIFTQDEELSSEEEGSEYPTFTQNNFLT
Protein: Chlorophyllase type 0 (EC 3.1.1.14) (CaCLH0) (Chlorophyll-chlorophyllido hydrolase 0) (Chlase 0) (Q9LE89)
Organism: Chenopodium album (Fat hen)
Function: Catalyzes the hydrolysis of ester bond in chlorophyll to yield chlorophyllide and phytol.
Interaction partners:
Sequence:
MAKLLLLIFGVFIFVNSQAQTFPTILEKHNSEKITDVFHKGNFQVTNNPIRVKRYEFSAPEPLIIISPKEAGVYPVLLFIHGTMLSNEDYSLFFNYIASHGFIVVAPKLFRLFPPKLPSQQDEIDMAASVANWMPLYLQVVLQRYVTGVEGDLEKLAISGHSRGGKSAFALALGFSNIKLDVTFSALIGVDPVAGRSVDDRTLPHVLTYKPNSFNLSIPVTVIGSGLGNHTISCAPNHVSHQQFYDECKENSSHFVITKYGHMDMLNEFRLSPIAVTMSLMCAQSFRPKATMRRTLGGIMVAFLNAYFRDDGRQYYAIIANRSLAPTNLFAEKKGFNFGFATTYAQL
Protein: R-spondin-3 (Cabriolet) (Roof plate-specific spondin-3) (Q5R328)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q2TJ95}.
Interaction partners:
- Leucine-rich repeat-containing G-protein coupled receptor 4
- E3 ubiquitin-protein ligase znrf3
- R-spondin-2
- R-spondin-1
Sequence:
MQLQLISIVLILHFMEYTNCQHHGSRHRGNKQVSGVSSQGCQGGCQTCSVYNGCLTCKPKLFIHLERDGMRQIGVCLASCPNGFYGTRSPDRNDCIKCGSECDSCFNRNFCLRCRAGSYLHKGKCMESCPDGLVPSDTKKECVAACPALCDLCQNSDTCTRCVPGHFLHAGQCHHVCPDEFEPNDSMECIPTVHCEVSEWSEWGTCSRSGKTCGFKWGEETRTRKVLQNPSPMGSPCPPTSEKRECFVKKKRCKPPKGQRRGEKKKRFNLQEKVTAEARRERKREREKETIDREESENRNKTEQRRRRDQSRDAGTV
Protein: Regeneration, isoform B (Regeneration, isoform C) (M9PFV8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO10847p1
- IP09724p
Sequence:
MCGSHKMWCCQVFILALFAHTIAVEFHGSAARAEINFEGPSPAHSQDTAAPTSRPKRRVYALCPPKFHRVGTDCYSLVDQRSSWLEAHFFCKDKNANLTEPGKHADRKLRLFLQKQDALSGENDPIWLGATYDHHNNRWQWSMSGRNLSTDSFSRTDSAYVQLISNSQPLDNNCAIYDPSLKYRWSARPCSDKLRFICQHKMPKVSGPNRYKIYNRWNATYPNEQANEVVLEILEPRENDRRYHRRVKAEDSDEEMIIPDRRRNNNRRNNHRNRQIKNQNQHPNDVNYQPAQQRQRNRPRTSTVAPTTTQSVSQSNDVLAPSPTPQQMTQYDRKLQRQRERERRRQLRRQERQKLAREQKRERQRRLKEERQRLQREEQQRRQRLHHDEPKPQVNPQVKPQVIDELRQRSGEDLDKNQTDEHEQKLRNEQEKKLREEQQKQRDEQEQKDREEQDRLKQEEEQARTHQKELKENQEQQLRELKAKQEREKQERDYQQQKREHELELLKQRQAEADRQHAADEEAEKLRLERIQKQRELEAQQRREREEQRRKQREEQEEQDRQNHAKRLAEEKRLHDLYAERIRLANTEREKQLAEAHEAKRLEELKLQEQLKKQEDERQEQIRREQEEEEKRLELERLEEARRFEEKELKRLHEENQRREEQKLQREREIALREAAEKKLAEEEEMLRKEVAEEERKVKQRLEDEMRQAEEARKAKEAEERAAEEAKAAEQKRRVEAAKKKADEEVKAKLEEKRREYVTRISALSPEDQKKFIEMRKRRKQLKEKKERDQRAKELKRIQQAMRLDDNE
Protein: Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) (P00637)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Interaction partners:
- Fructose-bisphosphate aldolase B
- Phosphofructokinase domain-containing protein
- Transketolase
- ATP-dependent 6-phosphofructokinase, muscle type
- Transketolase like 1
- Fructose-bisphosphate aldolase
- Fructose-bisphosphate aldolase A
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Sequence:
MADKAPFDTDISTMTRFVMEEGRKAGGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSTKDALQPGRNLVAAGYALYGSATMLVLAGGSGVNSFMLDPAIGEFILVDKNVKIKKKGNIYSLNEGYAKDFDPAVTEYIQKKKFPPDNSSPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPDGKLRLLYECNPMAFIMEKAGGMATTGKEAILDIVPTDIHQRAPVILGSPDDVQEFLEIYKKHAVK
Protein: Cysteine synthase (EC 2.5.1.47) (B9DFR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVAMIMASRFNREAKLASQILSTLLGNRSCYTSMAATSSSALLLNPLTSSSSSSTLRRFRCSPEISSLSFSSASDFSLAMKRQSRSFADGSERDPSVVCEAVKRETGPDGLNIADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYETTGPEIWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVVFPSFGERYLSTPLFQSIREEVEKMQPERVSG
Protein: Transmembrane 7 superfamily member 3 (NARP1) (Q9CRG1)
Organism: Mus musculus (Mouse)
Function: Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9NS93}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MWRLRLLVLAVLAAGSAEAQANSSDGFLEFSVGKFTYFVLSKSSPQEAVLRHISSNVTFLLFQIHSQYQNTTVSFTKTLLPSTSGTGNDRGLVFILRPEQAVCTWYLETGDTKPVQSVALTLSYSERDPIPGGCNLEFDLDIDPNLYLDYNFFETTIKFAPANIGYARATEPPPCDVSTSRESRWRLRYDVYQYFLPEGDLTEASLLHHLQRMAQVAQVKASAIKVATLTADDKTAVSFSSLPGQGVIYNVIVWDPSLNTSAAYVPVHTYACSFESVDGNCASPGRVSTKVFSTLFALLGLFVCFFGHRFWKTDLFFVGFIFLGFFFYILITRLTPLQYDVRLALTAVAGSFGGLLLVASWWRFGILTLCMLCVGLVLGFLVSSGTFFTPLGNLNVFHDDGVFWVTFSCIALLVPVIFMGCLRILNILACGVVGSYSVVLAVNSYMFTSLSYITLNVLRRALNTDFRGAFIRVPFQTNDYIILAVWGMLAVSGITLQIRRERGQPPFPPHPYKLWKQERERRVTNILDPSHHIPPLRERLYGRVARIKELFQKEQPAGERTPLLL
Protein: Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) (P63242)
Organism: Mus musculus (Mouse)
Function: mRNA-binding protein involved in translation elongation (By similarity). Has an important function at the level of mRNA turnover, probably acting downstream of decapping (By similarity). Critical for the efficient synthesis of peptide bonds between consecutive proline residues (By similarity). Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (By similarity). Regulates also TNF-alpha-mediated apoptosis (By similarity). Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17707773}. Nucleus {ECO:0000269|PubMed:17707773}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P63241}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63241}; Cytoplasmic side {ECO:0000250|UniProtKB:P63241}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. Nuclear export of hypusinated protein is mediated by XPO4. {ECO:0000250|UniProtKB:P63241}.
Interaction partners:
- Deoxyhypusine synthase
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL18
- Elongation factor 2
- Exportin-4
- Small ribosomal subunit protein uS19
- Deoxyhypusine hydroxylase
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL23
Sequence:
MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK
Protein: Pyrethroid hydrolase Ces2a (EC 3.1.1.88) (Carboxylic ester hydrolase 2A) (EC 3.1.1.-) (carboxylesterase 2A) (Q8QZR3)
Organism: Mus musculus (Mouse)
Function: Carboxylesterases that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes permethrin faster than cypermethrin. Hydrolyzes retinyl esters (By similarity).
Subcellular location: Microsome {ECO:0000250|UniProtKB:Q8K3R0}.
Interaction partners:
- UDP-glucuronosyltransferase 2B17
- Cytidine deaminase
- Beta-glucuronidase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase 2A3
- Ornithine transcarbamylase, mitochondrial
- UDP-glucuronosyltransferase
- Cytochrome P450, family 2, subfamily c, polypeptide 68
- Fatty acid-binding protein, intestinal
- UDP-glucuronosyltransferase
Sequence:
MPLARLPGWLCVVACGLLLLLQHVHGQDSASPIRNTHRGQVRGSFVHVKDTKSGVHAFLGIPFAKPPVGLLRFAPPEDPEPWSGVRDGTSQPAMCLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIYTPTHAQEGSNLPVMVWIHGGGLVVGSASMNDVSKLAATEEIVIVAIQYRLGVLGFFSTGDQHARGNWGYLDQVAALRWVQKNIAYFGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVALLPDLISDTSEVVYKTVANLSGCEATDSEALIHCLRAKSKQEILAINQVFKMIPAVVDGEFLPKHPQELLTSMDFHPVPSIIGVNTDECGWGVPMFMGLDHIIKNITRETLPAVLKNTAARMMLPPECSHLLVEEYMGDTEDPETLQAQFREMLGDFMFVIPALQVAHFQRSQAPVYFYEFQHLSSFIKHVRPSHVKADHGDDVAFVFGSYLWDMNLDLTEEEELLKRMMMKYWANFARNGNPNSEGLPSWPVLDHDEQYLQLDTQPAVGRALKARRLQFWTKTLPQKIQELKGSQDKHAEL
Protein: At4g21890 (Zinc finger MYND domain protein) (O49712)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDLHLKNLFGRFQEQFGSGPGLGPGSGVCLMIVEGISSNIIQSIFRASASLYSSEPWKRLRPGHLFGVRVGKDSDWSGKRQPFQCVQFIGGDGGDIAIYMYRSMSYALKMTDGDSWEMARDPNVEVFRVTYELESLMLPSNKRMVKSLSLEVSGTDRFPIMDVARCMTSGELQFRSPTLEELRLVFAVMKALSLVHPLLLQEEKQVRGLPRMIKFSPFIETVDVQWPSEMGKGHDFVAVTVSHPPGQSYEQKREDDELEIVSGMTA
Protein: Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein homolog) (WASp) (P70315)
Organism: Mus musculus (Mouse)
Function: Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P42768}. Nucleus {ECO:0000250|UniProtKB:P42768}.
Interaction partners:
- Cell division control protein 42 homolog
- Actin-related protein 2
- WAS/WASL-interacting protein family member 1
- Hematopoietic lineage cell-specific protein
- Src substrate cortactin
- SH2/SH3 adapter protein Nck1
- Actin-related protein 2/3 complex subunit 2
- Cdc42-interacting protein 4
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 1B
Sequence:
MNSGPGPVGGRPGGRGGPAVQQNIPSNLLQDHENQRLFELLGRKCWTLATTVVQLYLALPPGAEHWTMEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYLTPTPFFHTFAGDDCQVGLNFADESEAQAFRALVQEKIQKRNQRQSGERRQLPPPPAPINEERRGGLPPVPPHPGGDHGGPSGGPLSLGLVTVDIQNPDITSSRYRGLPAPGPGPTDKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQEPLPPPPPPCRGGGGGGGGGGGGGGGGGGQPLRPPVVGSNKGRSGPLPPVPMGGAPPPPTPRGPPPPGRGGPPPPPPPATGRSGPPPPPLPGAGGPPAPPPPPPPPPPPPCPGSGPAPPPLPPTPVSGGSPAPGGGRGALLDQIRQGIQLNKTPGALENSVQQPPAQQSEGLVGALMHVMQKRSRVIHSSDEGEDQTGEDEEDDEWDD