wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor elt-3 (B7WN96)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000269|PubMed:10191044}.
Interaction partners:
- Defective pharyngeal development protein 4
- Zinc finger transcription factor pqm-1
- Protein skinhead-1
- B lymphocyte-induced maturation protein 1 homolog
- Transcription factor elt-2
- Nuclear hormone receptor family member nhr-25
- Transcription factor elt-6
- Signal transducer and activator of transcription b
Sequence:
METANYYLPSPPYSSTSSSDSRESRMNTPIPTTYSEENVNSLFHLMPDNTDQWMTSQKNFWQEGSPSSSEYLHQQAVQPSQQARLPGISNFMKDSQLSVKPAAYYCSPTMNDYRVEKVANTLLDPYVQLDQPTYADFTNAQVLNHQQEMLQMNFPTPLSTSYMNTAQVTQTHQMPFNIFELNLSNFATFQPACDTPLPLLNSSPTHPYTTMSNFTPPPQDPLVAEPKPMKKRMAAVQCHQNSICSNCKTRETTLWRRNGEGGVECNACNLYFRKNNRKRPLSLRKDGIMKRNRRPRNESPNSAIRNTHQRHGHAAAC
Protein: tRNA (34-2'-O)-methyltransferase regulator trm734 (Q9USZ0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play a role in the regulation of the retromer complex and in the recycling from endosomes of plasma membrane proteins. May be involved in the methylation of the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)) by SPAC4F10.03c (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- tRNA
- tRNA
- Putative tRNA pseudouridine synthase C16C4.06c
- tRNA
- tRNA
- rRNA methyltransferase 2, mitochondrial
- Putative ribosomal RNA methyltransferase PB17E12.10c
- U3 small nucleolar RNA-associated protein 15
- tRNA
- S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
Sequence:
MLVEGDKGVLEPVNFVGPVTSLALIHNDKFLCCAQGPCLRIYDVSESRHESDLIKSILLPFHNRIHGMLPCKQGLFVWGGTYFAVVDVETSQVYYDRISDWIFNAAELGEENKFCVVTSKNQVHLLSLSKGSWEVTNTISCEKTPLLFCATVQISGNEIYIASASAFQQIYVWKFNYNNPPSCVSIDTYLVGHEGACFDLKFSSDGRYLCSVSEDRTLRLWSIESSPFLIATGFGHSARVWRCVFLPNKEIATVSEDLTLRLWTWNDKTLTNTYTYTGHRGKHIWSLVVSSANPIIYTGGNDGSVRSWDYKTRIQESCISVSSLFTSKTLLASFCFVKCQKLLCLAKNGEMSIIDNKGKKAIPALTTTSDMSIIRSWKNSFFVAAASNKGTIYVFSYQNTNLLKAIDLHRGKIQQLLTYQVKERYFLLSKSFVGKNQFRVYLQEFDFEADKVNLISTIELELPATFDPTSLTVDEEYSNFLIGSRTGSLALYNIGESNYLSVWRRIHEFDAISSIHIKSSKRDYLLIQTVGRDGYVNLFSIPRVEKSAVPQELCSKKCCDGILSGGLCKKLKNGKENQWVWGFHASNFFLRDETNETNVFFIDCGGSHRPWAFSMEMDIQSFASYRANQLYIYSTALNLLQRNSVLQNGLHGREIRAMDFNPSGDLLLSGSEDTKVTLLEFQSNGNIIPLNSVKFHNSGIQSLTWFSDDILFSTGGLEELNVYRLIQKPEAYLKRIVHEKLCKPNKSNKTYDGDLRITDISVVKATHLGERVLWINTVQSDSTIKAFTYNVDTKQLNCIKSWKYKTVCLVFAEAVIFGSHLLLVVASTDGNVAIWNTFWRDPQIEPLIIWIKTVHQFCVKSLNISRDQDVLTISTGGDDGAISRSILLLEQISENSVVVNSLHNYFFAEAHASSVTGVLSITKELLLSVSIDQRILLWKVEGDSLKPILERYTHVADVGGMIRNNDFLIIYGIGCEVFRLGSLR
Protein: SPARC-related modular calcium-binding protein 1 (SPARC-related gene protein) (Secreted modular calcium-binding protein 1) (SMOC-1) (Q8BLY1)
Organism: Mus musculus (Mouse)
Function: Probable regulator of osteoblast differentiation. Plays essential roles in both eye and limb development.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Note=In or around the basement membrane. {ECO:0000250}.
Interaction partners:
- Sodium-coupled neutral amino acid transporter 4
Sequence:
MLPARVRLLTPHLLLVLVQLSPAGGHRTTGPRFLISDRDPPCNPHCPRTQPKPICASDGRSYESMCEYQRAKCRDPALAVVHRGRCKDAGQSKCRLERAQALEQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGPVTDKPLSQGNSGRKVSFRFFLTLNSDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNVRNSEKVHSCDQERQSALEEARQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDTGRPLPGTSTRYVMPSCESDARAKSVEADDPFKDRELPGCPEGKKMEFITSLLDALTTDMVQAINSAAPTGGGRFSEPDPSHTLEERVAHWYFSQLDSNSSDDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGCLGVSKEGGSLGSFPQGKRAGTNPFIGRLV
Protein: Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Protein GIG47) (Secreted protein of unknown function) (SPUF protein) (Q9UMX5)
Organism: Homo sapiens (Human)
Function: Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity).
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:31536960}. Mitochondrion {ECO:0000269|PubMed:31536960}. Endoplasmic reticulum {ECO:0000269|PubMed:31536960}. Note=Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7. {ECO:0000269|PubMed:31536960}.
Interaction partners:
- Cytochrome b5 type B
- Cytochrome b5
- Corepressor interacting with RBPJ 1
Sequence:
MVGPAPRRRLRPLAALALVLALAPGLPTARAGQTPRPAERGPPVRLFTEEELARYGGEEEDQPIYLAVKGVVFDVTSGKEFYGRGAPYNALTGKDSTRGVAKMSLDPADLTHDTTGLTAKELEALDEVFTKVYKAKYPIVGYTARRILNEDGSPNLDFKPEDQPHFDIKDEF
Protein: L-asparagine permease (L-asparagine transport protein) (P77610)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
Sequence:
MSKHDTDTSDQHAAKRRWLNAHEEGYHKAMGNRQVQMIAIGGAIGTGLFLGAGARLQMAGPALALVYLICGLFSFFILRALGELVLHRPSSGSFVSYAREFLGEKAAYVAGWMYFINWAMTGIVDITAVALYMHYWGAFGGVPQWVFALAALTIVGTMNMIGVKWFAEMEFWFALIKVLAIVTFLVVGTVFLGSGQPLDGNTTGFHLITDNGGFFPHGLLPALVLIQGVVFAFASIEMVGTAAGECKDPQTMVPKAINSVIWRIGLFYVGSVVLLVMLLPWSAYQAGQSPFVTFFSKLGVPYIGSIMNIVVLTAALSSLNSGLYCTGRILRSMAMGGSAPSFMAKMSRQHVPYAGILATLVVYVVGVFLNYLVPSRVFEIVLNFASLGIIASWAFIIVCQMRLRKAIKEGKAADVSFKLPGAPFTSWLTLLFLLSVLVLMAFDYPNGTYTIAALPIIGILLVIGWFGVRKRVAEIHSTAPVVEEDEEKQEIVFKPETAS
Protein: 2-oxoglutarate oxidoreductase OorD subunit (B5Z6V9)
Organism: Helicobacter pylori (strain G27)
Interaction partners:
Sequence:
MAKMSTPDGVAVWVNEDRCKGCDICVSVCPAGVLGMGIEKERVLGKVAKVAYPESCIGCVQCELHCPDFAIYVADRKDFKFAKVSKEAQERSEKVKANKYMLLEETILEGRGK
Protein: MARVEL domain-containing protein 3 (Q96A59)
Organism: Homo sapiens (Human)
Function: As a component of tight junctions, plays a role in paracellular ion conductivity.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000269|PubMed:20028514}.
Interaction partners:
Sequence:
MEDPSGAREPRARPRERDPGRRPHPDQGRTHDRPRDRPGDPRRKRSSDGNRRRDGDRDPERDQERDGNRDRNRDRERERERERDPDRGPRRDTHRDAGPRAGEHGVWEKPRQSRTRDGARGLTWDAAAPPGPAPWEAPEPPQPQRKGDPGRRRPESEPPSERYLPSTPRPGREEVEYYQSEAEGLLECHKCKYLCTGRACCQMLEVLLNLLILACSSVSYSSTGGYTGITSLGGIYYYQFGGAYSGFDGADGEKAQQLDVQFYQLKLPMVTVAMACSGALTALCCLFVAMGVLRVPWHCPLLLVTEGLLDMLIAGGYIPALYFYFHYLSAAYGSPVCKERQALYQSKGYSGFGCSFHGADIGAGIFAALGIVVFALGAVLAIKGYRKVRKLKEKPAEMFEF
Protein: FUN14 domain containing 2B (Q9D9Q3)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004374}.
Interaction partners:
Sequence:
MTTNTSTTTTATVARSISSFTDPHHFPSHNHIIRMASASQGHFDAYEALDLTEFAKKQPWWRKLFGQESRSAGEKYSVATQLLIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWSRVEKDMKKAKEQLTIRKSAQIPTEVKSKAEEVVCFVKKNVLVTGGFFGGFLLGMAS
Protein: RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related) (Q8WXA3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ephrin type-A receptor 3
- RUN and FYVE domain-containing protein 1
Sequence:
MATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSSNLP
Protein: Oligopeptide/dipeptide ABC transporter, permease protein (Q5LSV9)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}.
Interaction partners:
- Oligopeptide/dipeptide ABC transporter, ATP-binding protein
- Oligopeptide/dipeptide ABC transporter, permease protein
- Oligopeptide/dipeptide ABC transporter, periplasmic substrate-binding protein
- Dipeptide ABC transporter, periplasmic dipeptide-binding protein
- Dipeptide ABC transporter, permease protein
- Oligopeptide ABC transporter, ATP-binding protein
- Fatty acid desaturase family protein
- Sarcosine oxidase, gamma subunit family
- Methyltransferase
Sequence:
MEPLGTFEIIIRVLYQLSSVWIALLLLFALSIAFKRRLGLYGKLFDSPIGMIGFALVMFWVFVGIFGAMDMIITHDPLSQVSGMKNKVPGTPLAGAAEGDYAWYLLGGDNLARDVFSRVIKGAWIVVQIAPLATLFAFMVGITLGLPAGYYGGRLDTFLSFLANLILAFPVILLFYLLVTPEIVATGLPTMMAIVLFMFPIVFLCVLLNSRYRTQPAFRTPLLIGVLGFALWLYLALISENGYLVRSIPGLPSVLDPFDIPGGILVVFVSVVFVNSPTVFRIVRGLAMDIKTRDYVAAAQTRGEGPWYIMLWEILPNARGPLIVDFCLRIGYTTILLGTLGFFGLGLPPESPDWGSTINEGRKLLSIYLHPALPPALALLSLVLGLNLLADGLREESLKD
Protein: Toll-like receptor 9 (CD antigen CD289) (Q9NR96)
Organism: Homo sapiens (Human)
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14716310}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9EQU3}. Early endosome membrane {ECO:0000269|PubMed:14716310}. Lysosome {ECO:0000250|UniProtKB:Q9EQU3}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9EQU3}. Golgi apparatus membrane {ECO:0000269|PubMed:38169466}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid. {ECO:0000250|UniProtKB:Q9EQU3, ECO:0000269|PubMed:14716310, ECO:0000269|PubMed:38169466}.
Interaction partners:
- Myeloid differentiation primary response protein MyD88
- High mobility group protein B1
- Toll-like receptor 7
- Interleukin-1 receptor-associated kinase 1
- Toll/interleukin-1 receptor domain-containing adapter protein
- TNF receptor-associated factor 6
- Toll-like receptor 4
- Interleukin-1 beta
- Protein unc-93 homolog B1
- TIR domain-containing adapter molecule 1
Sequence:
MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE
Protein: Putative methyl-CpG-binding domain protein 3-like 3 (MBD3-like protein 3) (A6NE82)
Organism: Homo sapiens (Human)
Interaction partners:
- Methyl-CpG-binding domain protein 3-like 2
- Methyl-CpG-binding domain protein 3-like 5
- Paired-like homeodomain transcription factor LEUTX
Sequence:
MGEPAFTSFPSPPVLGKLKRNMMPWALQKKREIHMAKAHRRRAARSALPMRLTSCIFRRPVTRIRSHPDNQVRRRKGDEHLEKPQQLCAYRRLQALQPCSSQGEGSSPLHLESVLSILAPGTAGESLDRAGAERVRSPLEPTPGRFPAVAGGPTPGMGCQLPPPLSGQLVTPADIRRQARRVKKARERLAKALQADRLARQAEMLTCR
Protein: Eukaryotic translation initiation factor 4E type 5 (Q38B99)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEEESHALKDPWFVSYIPQLTTEIVKNNYEGDWNLAKEALQQPLDYVRTVEEFWSTLNSLPKLHQLESSSTFVFARNNVDASYEAFPNGTRIIVDIRKAAMAEKATAVILSSVIGESVSQEVCGGKPICDVLRLSSRPNKESPELVRLEVWLSDQTYGKAVLAYVRKALNDVGMSQPHVIFGESLFEKEKKKKGK
Protein: Sorting assembly machinery 37 kDa subunit (MAS37 protein) (Mitochondrial 37 kDa outer membrane protein) (P50110)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:16823961}; Multi-pass membrane protein {ECO:0000269|PubMed:16823961}.
Interaction partners:
- Mitochondrial import receptor subunit TOM22
- Mitochondrial distribution and morphology protein 10
- Sorting assembly machinery 50 kDa subunit
- Mitochondrial import receptor subunit TOM40
- Sorting assembly machinery 35 kDa subunit
- Mitochondrial import receptor subunit TOM5
- Mitochondrial import receptor subunit TOM6
- Mitochondrial import receptor subunit TOM70
- Mitochondrial import receptor subunit TOM20
- Mitochondrial import receptor subunit TOM7
Sequence:
MVKGSVHLWGKDGKASLISVDSIALVWFIKLCTSEEAKSMVAGLQIVFSNNTDLSSDGKLPVLILDNGTKVSGYVNIVQFLHKNICTSKYEKGTDYEEDLAIVRKKDRLLEYSLLNYVDVEISRLTDYQLFLNTKNYNEYTKKLFSKLLYFPMWYNTPLQLRSQARENCEEIIGSLTLEDDEEFVESKAMESASQLAQSKTFKIAHKNKIKGKQELQQVKYNLQFDNRLQSCVSNWLAARKKLDDSVILSSDLLFLANLYVQLGLPDGNRIRSKLEQTFGSELLNSMSNKIDDFVHRPSNNLEQRDPQFREQGNVVMSLYNLACKYI
Protein: Kinesin light chain (B2GV74)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367020}.
Interaction partners:
- Kinesin-1 heavy chain
- Kinesin heavy chain isoform 5A
- Kinesin heavy chain isoform 5C
- Calsyntenin-1
- Kinesin light chain 1
- Kinesin light chain 3
- C-Jun-amino-terminal kinase-interacting protein 3
- Kinesin light chain 4
- Huntingtin-associated protein 1
- Glycogen synthase kinase-3 beta
Sequence:
MATMVLPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLASHEAGEAEPGSQERCLLLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDSLDDLFPNEDEQSPAPSPGGGDVAAQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGENKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRSRKQGLDPASQTKVVELLKDGSGGRGDRRGSRDVAGGAGPRSESDLEESGPAAEWSGDGSGSLRRSGSFGKLRDALRRSSEMLVRKLQGGGPQEPPNSRMKRASSLNFLNKSVEEPVQPGGTGLSDSRTLSSSSMDLSRRSSLVG
Protein: Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin) (Q96BP3)
Organism: Homo sapiens (Human)
Function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:18397323}. Note=Associated with spliceosomal complexes. {ECO:0000269|PubMed:11991638}.
Interaction partners:
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor SYF2
- Peptidyl-prolyl cis-trans isomerase-like 1
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
- Pre-mRNA-processing-splicing factor 8
- Peptidyl-prolyl cis-trans isomerase G
- Crooked neck-like protein 1
- U2 small nuclear ribonucleoprotein A'
- Cell division cycle 5-like protein
- Pre-mRNA-splicing factor CWC22 homolog
Sequence:
MAAESGSDFQQRRRRRRDPEEPEKTELSERELAVAVAVSQENDEENEERWVGPLPVEATLAKKRKVLEFERVYLDNLPSASMYERSYMHRDVITHVVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFDESLSMFTELQQMRQQLPDMEFGRRMAVERELEKVDAVRLINIVFDETGHFVLYGTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHRAATTIEMKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREPEDTKSADSDRDVFNEKPSKEEVMAATQAEGPKRVSDSAIIHTSMGDIHTKLFPVECPKTVENFCVHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGMGGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPTPWLDNKHTVFGRVTKGMEVVQRISNVKVNPKTDKPYEDVSIINITVK
Protein: Phenazine biosynthesis-like domain-containing protein (EC 5.1.-.-) (MAWD-binding protein) (MAWDBP) (Unknown protein 32 from 2D-page of liver tissue) (P30039)
Organism: Homo sapiens (Human)
Interaction partners:
- Serine-threonine kinase receptor-associated protein
- Antizyme inhibitor 2
- Ornithine decarboxylase
- Antizyme inhibitor 1
Sequence:
MKLPIFIADAFTARAFRGNPAAVCLLENELDEDMHQKIAREMNLSETAFIRKLHPTDNFAQSSCFGLRWFTPASEVPLCGHATLASAAVLFHKIKNMNSTLTFVTLSGELRARRAEDGIVLDLPLYPAHPQDFHEVEDLIKTAIGNTLVQDICYSPDTQKLLVRLSDVYNRSFLENLKVNTENLLQVENTGKVKGLILTLKGEPGGQTQAFDFYSRYFAPWVGVAEDPVTGSAHAVLSSYWSQHLGKKEMHAFQCSHRGGELGISLRPDGRVDIRGGAAVVLEGTLTA
Protein: StAR related lipid transfer domain containing 10 (F5GY11)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEKLAASTEPQGPRPVLGRESVQCRMECCDVPAETLYDVLHDIEYRKKWDSNVIETFDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYIIMNYSVKHPKYPPRKDLVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKSSQFLAPKAMKKMYKACLKYPEWKQKHLPHFKPWLHPEQSPLPSLALSELSVQHADSLENIDESAVAESREERMGGAGGEGSDDDTSLT
Protein: Pentatricopeptide repeat-containing protein At1g02150 (Q8LPS6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RNA-binding
- AT3G20230 protein
- Pentatricopeptide repeat-containing protein At4g35850
- Small ribosomal subunit protein cS23y
- Pentatricopeptide repeat-containing protein At2g17033
- Multiple organellar RNA editing factor 2, chloroplastic
- RNA polymerase sigma factor sigB
- RNA-binding protein CP31B
- Large ribosomal subunit protein uL3c
- Small ribosomal subunit protein uS3m
Sequence:
MLLQAAVQNRNVPLASSASYSRLLRCRSPVVSVAALSKKTAAIVCSISQVYGYGTVDYERRPIVQWNAIYKKISLMEKPELGAASVLNQWEKAGRKLTKWELCRVVKELRKYKRANQALEVYDWMNNRGERFRLSASDAAIQLDLIGKVRGIPDAEEFFLQLPENFKDRRVYGSLLNAYVRAKSREKAEALLNTMRDKGYALHPLPFNVMMTLYMNLREYDKVDAMVFEMKQKDIRLDIYSYNIWLSSCGSLGSVEKMELVYQQMKSDVSIYPNWTTFSTMATMYIKMGETEKAEDALRKVEARITGRNRIPYHYLLSLYGSLGNKKELYRVWHVYKSVVPSIPNLGYHALVSSLVRMGDIEGAEKVYEEWLPVKSSYDPRIPNLLMNAYVKNDQLETAEGLFDHMVEMGGKPSSSTWEILAVGHTRKRCISEALTCLRNAFSAEGSSNWRPKVLMLSGFFKLCEEESDVTSKEAVLELLRQSGDLEDKSYLALIDVDENRTVNNSEIDAHETDALLTQLQDDL
Protein: Uncharacterized urease accessory protein ureD-like (P87125)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probably facilitates nickel incorporation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized urease accessory protein UreF-like
- Bifunctional purine biosynthetic protein ADE1
- Uncharacterized urease accessory protein ureG-like
- Phosphoribosylformylglycinamidine synthase
- Urease
- Amidophosphoribosyltransferase
- Phosphoribosylglycinamide formyltransferase
- Alpha-ketoglutarate-dependent xanthine dioxygenase xan1
- Adenylosuccinate synthetase
- Inosine-5'-monophosphate dehydrogenase
Sequence:
MEDKEGRFRVECIENVHYVTDMFCKYPLKLIAPKTKLDFSILYIMSYGGGLVSGDRVALDIIVGKNATLCIQSQGNTKLYKQIPGKPATQQKLDVEVGTNALCLLLQDPVQPFGDSNYIQTQNFVLEDETSSLALLDWTLHGRSHINEQWSMRSYVSKNCIQMKIPASNQRKTLLRDVLKIFDEPNLHIGLKAERMHHFECIGNLYLIGPKFLKTKEAVLNQYRNKEKRISKTTDSSQMKKIIWTACEIRSVTIIKFAAYNTETARNFLLKLFSDYASFLDHETLRAFWY
Protein: Dermatan-sulfate epimerase-like protein (EC 5.1.-.-) (Q8IZU8)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MALMFTGHLLFLALLMFAFSTFEESVSNYSEWAVFTDDIDQFKTQKVQDFRPNQKLKKSMLHPSLYFDAGEIQAMRQKSRASHLHLFRAIRSAVTVMLSNPTYYLPPPKHADFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFVLEYMDRMVGYKDWLVENAPGDEVPIGHSLTGFATAFDFLYNLLDNHRRQKYLEKIWVITEEMYEYSKVRSWGKQLLHNHQATNMIALLTGALVTGVDKGSKANIWKQAVVDVMEKTMFLLNHIVDGSLDEGVAYGSYTAKSVTQYVFLAQRHFNINNLDNNWLKMHFWFYYATLLPGFQRTVGIADSNYNWFYGPESQLVFLDKFILKNGAGNWLAQQIRKHRPKDGPMVPSTAQRWSTLHTEYIWYDPQLTPQPPADYGTAKIHTFPNWGVVTYGAGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYSWIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPSSQCNKPWEGQLGECAQWLKWTGEEVGDAAGEIITASQHGEMVFVSGEAVSAYSSAMRLKSVYRALLLLNSQTLLVVDHIERQEDSPINSVSAFFHNLDIDFKYIPYKFMNRYNGAMMDVWDAHYKMFWFDHHGNSPMASIQEAEQAAEFKKRWTQFVNVTFQMEPTITRIAYVFYGPYINVSSCRFIDSSNPGLQISLNVNNTEHVVSIVTDYHNLKTRFNYLGFGGFASVADQGQITRFGLGTQAIVKPVRHDRIIFPFGFKFNIAVGLILCISLVILTFQWRFYLSFRKLMRWILILVIALWFIELLDVWSTCSQPICAKWTRTEAEGSKKSLSSEGHHMDLPDVVITSLPGSGAEILKQLFFNSSDFLYIRVPTAYIDIPETELEIDSFVDACEWKVSDIRSGHFRLLRGWLQSLVQDTKLHLQNIHLHEPNRGKLAQYFAMNKDKKRKFKRRESLPEQRSQMKGAFDRDAEYIRALRRHLVYYPSARPVLSLSSGSWTLKLHFFQEVLGASMRALYIVRDPRAWIYSMLYNSKPSLYSLKNVPEHLAKLFKIEGGKGKCNLNSGYAFEYEPLRKELSKSKSNAVSLLSHLWLANTAAALRINTDLLPTSYQLVKFEDIVHFPQKTTERIFAFLGIPLSPASLNQILFATSTNLFYLPYEGEISPTNTNVWKQNLPRDEIKLIENICWTLMDRLGYPKFMD
Protein: Interleukin-1 alpha (IL-1 alpha) (P16598)
Organism: Rattus norvegicus (Rat)
Function: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P01583}. Cytoplasm {ECO:0000250|UniProtKB:P01583}. Secreted {ECO:0000250|UniProtKB:P01583}. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Recruited to DNA damage sites and secreted after genotoxic stress. {ECO:0000250|UniProtKB:P01583}.
Interaction partners:
- Interleukin-1 receptor type 1
- Interleukin-1 beta
- Interleukin-1 receptor type 2
- Granulocyte-macrophage colony-stimulating factor
- Interleukin-2
- Interferon gamma
- Granulocyte colony-stimulating factor
- Interleukin-4
- Interleukin-10
- Interleukin-3
Sequence:
MAKVPDLFEDLKNCYSENEEYSSAIDHLSLNQKSFYDASYGSLHENCTDKFVSLRTSETSKMSTFTFKESRVVVSATSNKGKILKKRRLSFNQPFTEDDLEAIAHDLEETIQPRSAPHSFQNNLRYKLIRIVKQEFIMNDSLNQNIYVDMDRIHLKAASLNDLQLEVKFDMYAYSSGGDDSKYPVTLKVSNTQLFVSAQGEDKPVLLKEIPETPKLITGSETDLIFFWEKINSKNYFTSAAFPELLIATKEQSQVHLARGLPSMIDFQIS