wanglab/gogpt-training-data huggingface dataset:
Protein: Dipeptidase 3 (Membrane-bound dipeptidase 3) (MBD-3) (Protein expressed in male leptotene and zygotene spermatocytes 136) (MLZ-136) (Q9DA79)
Organism: Mus musculus (Mouse)
Function: Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine. The absence of activity may be due to the inability of serine (instead of aspartate found in DPEP1/2) at position 356 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide. Does not hydrolyze leukotriene D4 (LTD4) into leukotriene E4 (LTE4). Does not hydrolyze the beta-lactam antibiotic imipenem (By similarity).
Subcellular location: Membrane {ECO:0000269|PubMed:12738806}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12738806}.
Interaction partners:
- Testis-expressed protein 101
Sequence:
MQPAGLEGPRALGLRPLGHRLSLLGVLLLVPSLWVTCTLTTPSPSSAPTTPEASNATTAPGIPNDTATSGVTSDPRLREQALALMRDFPLVDGHNDLPLLLRELFQNQLQDVNLRNFTRGQTNLDRLRDGLVGAQFWSAYIPCQTQDRDAVRLALEQIDLIRRMCSAYPELELVTSADGLNNTQKLACLIGVEGGHSLDTSLAVLRSFYELGVRYLTLTFTCSTPWAESATKFRHHFYTNISGLTSFGEKVVEEMNRLGMMIDLSHASDTLVKQTLEVSQAPVIFSHSAARSVCDNLLNIPDDILQLLKKNGGIVMVTLSMGVLQCSLFANVSTVADHFDHIRTVIGSEFIGIGGSYDGSGRFPQGLEDVSTYPVLIEELLSRGWDERELQGVLRGNLLRVFRQVEQVREKSLGQSPVEVKFPERQQSNTCHSHLLPQPQEDQHQDTHLKVTKLPNILQRASKAPPHPLPGLMATLTSLALILWLCCSGHRAV
Protein: FERM and PDZ domain-containing protein 3 (Q5JV73)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQEESANDMECEQLPAEILRQVTVHRDPIYGFGFVAGSERPVVVRSVRPGGPSENKLLAGDQIVAINEEDVSEAPRERLIELIRSAKEFIVLTVLHTHQSPKSAFISAAKKAKLRSNPVKVRFSEQVAVGETDAKMMKKEALLLIPNVLKVFLENGQIKSFTFDGRTTVKDVMLTLQDRLSLRFIEHFALVLEYAGPEQNHKFLLLQDKQPLAYVVQRTHYHGMKCLFRISFFPKDPVELLRRDPAAFEYLYIQSRNDVIRERFGMDPKPEMLLGLAALHIYITVSATRPSQKISLKNVEKEWGLEPFLPPSLLQVIKEKNLRKSLSQQLKAHQTHPSCGTKGSAIQAKLQYLRILNELPTFTGVLFNTVGLDEKQSATTLLVGPRHGISHVIDLKTNLTTVLSEFSKISKIQLFRENQGVARVETSIMDAKPLVLLMEWPEATNFACLIAGYCRLLLDSRKMVFSRPASQPLPPPMIKADYMHSAHRPVTGGHLGKKESSYVGSVGTSPRKSSRCTPPPADSELVSFCYLHMREQRKEQESRTDVNENLIFFEETRPRTKSDPTSKSSGQGYEVVPDDFDAASLDHEPCASRARSYTLDNSLGAEALNFYCDSCKAKLQEQLGPRKGGKPGSSRDNIVDLMSLPPPGSEEEEEEEDETTSLLPAIAAPPPGFRDNSSDEDDPKRRAVQSQEQGRHLRGLLYDEIPVTLIDSVQTRTVRDHAQELDDALVSTLQALEALAASEDGPHPPPPQTAGLIVLATITPESSLDSGHETNSSELTDMSEMMSAMKQHQNTTYFLAQHLNKDSLLARKDLPFRIQSCAAQAVLTAPYSLGRPDPNPSLQPIATGQSPGPPGARRKLPQSEGQVQGERTYSLAVHPALSPQLSEQKNLSLLSPVPEDKGPGHTRAGLEMSLRAATSSLSEEQVSELRDNLPKEVRLSPKLILDPKSSVTPAIISAALQQVVHNKSLVTAGGALGNPPSRGERRLEASMGRPEVSMMSSSASKNLKFKISPSAPETSWNSQHQLGAEVSSSPRAPTGSRADSLHLSQQEDSLPVQNFPPKSYLLRTSRESVGKQATGEVAGKGGPVGGKPTLQKQGTISSQGEKAQLESTPKRSKLEETSLVPRATYPMALQSPSCQSRSHSPSCQPHGHSPSSQSRGQSPSCQPRGQSPLRSQAASRQVSTMPSRKLETTLNGAHSTSEGPAKPKSSRGPFRLRNLFSATFPTRQKKETDERQAQLQKVKQYELEFLEELLKPPSQGELPGTEYLQPPAPGRCSCQLRSSPVQQGPGMSREQRRSCDCKRICRGGRPQATQTPVPSLRGRERDRVLPSQRQPEAGPGVSLSSPINVQRIRSTSLESRECRSDPESGVSCLTTCASGGECLGAPNYRKLMRRYSISELDQGDRASLTSDVYPHPPLGMLPREAKEVEASLPIALGPKSRSLESPTLGDPSYVQVAPETKGPRQMAVFSLPEEVYRKPAELDEDSESSKCCSIRYCFYYRKCDMADDASDGKDELSYSIPMKILPGMKLDEQVVPVVSRTLQVLDAATCSSSSPEASRTQEIDLRVSTFEGSLAKINALRAHAYGLPDGFLAARLDTNELLTVLRQCVASPEARAPKPYVSQISEYKLELALKFKELRASCRRVANVDKSPTHMLAAITGSFQVLSSLIETFVRLVFIVRSEAQRQELLAKVEEVVRNYTFLLRAAEESTARNLNQQQQQQQQQQQQQQQQQQQQQQQQQQQVAAAAGAATEHPPGSPTSATVMSTFTHSLKTLIK
Protein: Uncharacterized protein CC613.01 (O74901)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSTTTETVTWSQYKPQETQRRLSRSSTITPSVSEYRSGFSKTAFGNIELEEIPDKQGNITRATSNLESNSYPKALDPDACPPKRSIALVLLNNLMSEMSLTIALPISAAYTEILGGTDAFSGLVIGIPTMISLVCLYPMLRFANPKSANGYTLYFRPLIVSCISQIIGHLLYSLAYRAQWLYLILIGRMCSGVGFTMFLYHKTYLTDKNFVGQNRSTFLATLNILAQILGSMAGAFLGGILAKASMHLTDPIWNQYTAGSWFMLFIWIVYSIFLSIFFKEVRVGNTATNVRKPESFTGKTAPLSFKQKFMLCFLSMAAFISIFNVAGYQTSVPIYAKALYHYNPFQSGNFLSLSSLVIAPFVFFSTFLSKWLEDRQIMLYGFMMGIVALIVHLVLDAVHKIPVQPYFVLYSIMQFGFSVGSAPLVSLATKQLHPKYHMITGVVVQVGISIGETVGSICGGAIFDITTVGFIAMNLGIALLVFIQLLYLWTFIKTKTG
Protein: Pentatricopeptide repeat-containing protein At3g18110, chloroplastic (Protein EMBRYO DEFECTIVE 1270) (Q5G1S8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in embryogenesis.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- DNA mismatch repair protein MutS, type 2
- CRM-domain containing factor CFM2, chloroplastic
- PTI1-like tyrosine-protein kinase At3g15890
- Probable calcium-binding protein CML1
- Probable calcium-binding protein CML35
Sequence:
MAVSAGALAFPALSVRATLNPEIKDEQANISSTTSSSQKFTYSRASPAVRWPHLNLREIYDSTPSQTLSSPVSPIAGTPDSGDVVDSIASREEQKTKDETAVATRRRRVKKMNKVALIKAKDWRERVKFLTDKILSLKSNQFVADILDARLVQMTPTDYCFVVKSVGQESWQRALEVFEWLNLRHWHSPNARMVAAILGVLGRWNQESLAVEIFTRAEPTVGDRVQVYNAMMGVYSRSGKFSKAQELVDAMRQRGCVPDLISFNTLINARLKSGGLTPNLAVELLDMVRNSGLRPDAITYNTLLSACSRDSNLDGAVKVFEDMEAHRCQPDLWTYNAMISVYGRCGLAAEAERLFMELELKGFFPDAVTYNSLLYAFARERNTEKVKEVYQQMQKMGFGKDEMTYNTIIHMYGKQGQLDLALQLYKDMKGLSGRNPDAITYTVLIDSLGKANRTVEAAALMSEMLDVGIKPTLQTYSALICGYAKAGKREEAEDTFSCMLRSGTKPDNLAYSVMLDVLLRGNETRKAWGLYRDMISDGHTPSYTLYELMILGLMKENRSDDIQKTIRDMEELCGMNPLEISSVLVKGECFDLAARQLKVAITNGYELENDTLLSILGSYSSSGRHSEAFELLEFLKEHASGSKRLITEALIVLHCKVNNLSAALDEYFADPCVHGWCFGSSTMYETLLHCCVANEHYAEASQVFSDLRLSGCEASESVCKSMVVVYCKLGFPETAHQVVNQAETKGFHFACSPMYTDIIEAYGKQKLWQKAESVVGNLRQSGRTPDLKTWNSLMSAYAQCGCYERARAIFNTMMRDGPSPTVESINILLHALCVDGRLEELYVVVEELQDMGFKISKSSILLMLDAFARAGNIFEVKKIYSSMKAAGYLPTIRLYRMMIELLCKGKRVRDAEIMVSEMEEANFKVELAIWNSMLKMYTAIEDYKKTVQVYQRIKETGLEPDETTYNTLIIMYCRDRRPEEGYLLMQQMRNLGLDPKLDTYKSLISAFGKQKCLEQAEQLFEELLSKGLKLDRSFYHTMMKISRDSGSDSKAEKLLQMMKNAGIEPTLATMHLLMVSYSSSGNPQEAEKVLSNLKDTEVELTTLPYSSVIDAYLRSKDYNSGIERLLEMKKEGLEPDHRIWTCFVRAASFSKEKIEVMLLLKALEDIGFDLPIRLLAGRPELLVSEVDGWFEKLKSIEDNAALNFVNALLNLLWAFELRATASWVFQLGIKRGIFSLDVFRVADKDWGADFRRLSGGAALVALTLWLDHMQDASLEGYPESPKSVVLITGTAEYNGISLDKTLKACLWEMGSPFLPCKTRTGLLVAKAHSLRMWLKDSPFCFDLELKDSVSLPESNSMDLIDGCFIRRGLVPAFNHIKERLGGFVSPKKFSRLALLPDEMRERVIKTDIEGHRQKLEKMKKKKMGNETNGINTRRKFVRSK
Protein: Guanylyl cyclase domain containing 1 (A0A8I5ZSK9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLPRMGPGDLKETGHAWVTALLESGDQHLGGLCVGLTGCGLCLGESAGGMRTVSCGKAPEILESFCGANGALAGPVQSLRPHCRLFAEDFVQLPVPTIQQLYHWDCGLACSRMVLRYLGQLDDREFENALQELQLTRSIWTIDLAYLMRHFGVRHRFCTQTLGVDKGYKNQSFYRKHFDTEETRVNQLFAQAKACKVQVEKCTVSVQDIQAHLAQGHVAIVLVNSGVLHCELCSSPVKYCCFTPRGHRCFCRAPDYQGHFIVLRGYNRATGCIFYNNPAYADRMCSTSISNFEEARTSYGTDEDILFVYLDS
Protein: cDNA FLJ40572 fis, clone THYMU2006170 (Q7L8T7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSGGHSSPEPPRPWPLDRGSLPSPPAFPPGIATRATRAWAAPAKMLPCARSACRARDSGLASGTRAEVGGGPASEEYARRLAGCCPRLARPSLPTCEMHRTGLHLFNESFLSSCCEPGLEQAWVLWMGAGP
Protein: Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) (P29350)
Organism: Homo sapiens (Human)
Function: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:9065461}. Nucleus {ECO:0000269|PubMed:37595871}. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. {ECO:0000250}.
Interaction partners:
- B-cell receptor CD22
- Tyrosine-protein kinase SYK
- NKG2-A/NKG2-B type II integral membrane protein
- Leukocyte immunoglobulin-like receptor subfamily B member 1
- B-cell differentiation antigen CD72
- Tyrosine-protein kinase JAK2
- Platelet endothelial cell adhesion molecule
- Lymphocyte cytosolic protein 2
- Killer cell immunoglobulin-like receptor 2DL3
- Tyrosine-protein kinase JAK1
Sequence:
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
Protein: DNA topoisomerase IIB (Q63177)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
AQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVDNVRRMLEGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVETTELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (H7C560)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
Protein: Virulence-associated protein 1 (Q8I2F5)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MLNGKHLSKVFFFKISLILKLIWFLYFPYPKCELFQNKKHIRFLTQGKVEKDFNIRHVKIALKSNNMDLTTSQKNIDKKQIEYKDKDNINDKEQIYTSYNNSEFTPVYVTPTKKKNTKKNFITIKKIDIYFENLIYSFLESISYIEEPPDYELYNNEINQKMKEYLFIFEPVVLVFISVYYLAAEEYIISIIISFICSVILIYILIKIRKYDKAHNNFFTVSNMLKEFIQLIKNIPKNILNVVLHIPKKFIRIINYFKT
Protein: Glycogen synthase kinase-3 homolog YGK3 (EC 2.7.11.1) (Q12222)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for heat stress-instigated phosphorylation of BCY1 which is involved in cell wall integrity signaling. Regulates activity of MSN2, a transcription factor that binds to the stress-response element (STRE). Probably promotes formation of a complex between MSN2 and DNA. Regulates the stability of ROG1.
Interaction partners:
- Phosphoglucomutase 2
Sequence:
MLKVNNVFGSNPNRMTKLEDEHYFIDDIVSIKNRQKSKMYVREGKRIGHGSFGTVTQSILSSNSIEWLGPYAIKRVVKSPKVQSLELEILQNIRHPNLVTLEFFFESHCTTKDGGHLYQKNFVMEYIPQTLSSEIHEYFDNGSKMPTKHIKLYTFQILRALLTLHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDDNTELKTYFCSRFYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGDSANSQLEEIAKLLGRFPKSSIKNSQELQDSLNDQKFKKFMHWFPSIEFFDVEFLLKVLTYDATERCDARQLMAHEFFDALRNETYFLPRGSSMPVHLPDLFNFSASEKRALGEYYNLIVPSLD
Protein: Low glucose sensor SNF3 (High-affinity glucose receptor SNF3) (High-affinity transporter-like sensor SNF3) (Sucrose nonfermenting protein 3) (P10870)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: High-affinity low glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell. The transporter-like sensor generates an intracellular signal in the presence of low levels of glucose to promote low glucose-induced expression of HXT2. Binding of glucose to the SNF3 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane (By similarity). SNF3 is involved as well in the transport of mannose and fructose. Even though SNF3 is similar to glucose transporters, it appears to be unable to transport glucose.
Subcellular location: Cell membrane {ECO:0000269|PubMed:2406560, ECO:0000269|PubMed:3281163}; Multi-pass membrane protein {ECO:0000269|PubMed:3281163}.
Interaction partners:
- Carbon catabolite-derepressing protein kinase
- Hexokinase-2
- Glucose transport transcription regulator RGT1
- Hexokinase-1
- Glucokinase-1
- Protein STD1
- G protein-coupled receptor GPR1
- Guanine nucleotide-binding protein alpha-2 subunit
- High glucose sensor RGT2
- Regulatory protein MIG1
Sequence:
MDPNSNSSSETLRQEKQGFLDKALQRVKGIALRRNNSNKDHTTDDTTGSIRTPTSLQRQNSDRQSNMTSVFTDDISTIDDNSILFSEPPQKQSMMMSICVGVFVAVGGFLFGYDTGLINSITSMNYVKSHVAPNHDSFTAQQMSILVSFLSLGTFFGALTAPFISDSYGRKPTIIFSTIFIFSIGNSLQVGAGGITLLIVGRVISGIGIGAISAVVPLYQAEATHKSLRGAIISTYQWAITWGLLVSSAVSQGTHARNDASSYRIPIGLQYVWSSFLAIGMFFLPESPRYYVLKDKLDEAAKSLSFLRGVPVHDSGLLEELVEIKATYDYEASFGSSNFIDCFISSKSRPKQTLRMFTGIALQAFQQFSGINFIFYYGVNFFNKTGVSNSYLVSFITYAVNVVFNVPGLFFVEFFGRRKVLVVGGVIMTIANFIVAIVGCSLKTVAAAKVMIAFICLFIAAFSATWGGVVWVISAELYPLGVRSKCTAICAAANWLVNFICALITPYIVDTGSHTSSLGAKIFFIWGSLNAMGVIVVYLTVYETKGLTLEEIDELYIKSSTGVVSPKFNKDIRERALKFQYDPLQRLEDGKNTFVAKRNNFDDETPRNDFRNTISGEIDHSPNQKEVHSIPERVDIPTSTEILESPNKSSGMTVPVSPSLQDVPIPQTTEPAEIRTKYVDLGNGLGLNTYNRGPPSLSSDSSEDYTEDEIGGPSSQGDQSNRSTMNDINDYMARLIHSTSTASNTTDKFSGNQSTLRYHTASSHSDTTEEDSNLMDLGNGLALNAYNRGPPSILMNSSDEEANGGETSDNLNTAQDLAGMKERMAQFAQSYIDKRGGLEPETQSNILSTSLSVMADTNEHNNEILHSSEENATNQPVNENNDLK
Protein: Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Q09179)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- NADP-specific glutamate dehydrogenase
- Glutamate synthase
- Probable NAD-specific glutamate dehydrogenase
- Amidophosphoribosyltransferase
- Probable glutamine--fructose-6-phosphate aminotransferase
- Carbamoyl phosphate synthase arginine-specific small chain
- Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial
- Multifunctional protein ura1
- Putative glycine dehydrogenase
- Probable delta-1-pyrroline-5-carboxylate dehydrogenase
Sequence:
MSQYDVEPLLSKAAILNKYADLPQNGKVMAEYIWIDGFNHLRSKTMTLDAKPSSIDQLRVWNFDGSSTGQAPGNNSDTLLKPVAMYNDPFRRGDNILVLAACYTADGSPNGFNHRDACAKLLEKHADKETWFGIEQEYTMLDYYDRPFGWPKGGFPGPQGPFYCGVGTGRVFARDIVEAHYKACLYAGINISGINAEVMPSQWEYQVGPCAGIEMGDQLWMSRFLLHRIAEDFGVKISFHPKPILGDWNGAGCHTNVSTKDTRAEGGIKAIESYLEKFAKRHKEHIAVYGDDNDLRLTGRHETGSIDKFTYGVADRGASVRIPRSVAMNGCGYFEDRRPASSIDPYLVTGIITETMFEH
Protein: Sesquiterpene synthase 12 (ShTPS12) ((E)-beta-ocimene synthase TPS12) (EC 4.2.3.106) ((Z)-gamma-bisabolene synthase TPS12) (EC 4.2.3.-) (Alpha-humulene synthase TPS12) (EC 4.2.3.104) (Beta bisabolene synthase TPS12) (EC 4.2.3.-) (Beta caryophyllene synthase TPS12) (EC 4.2.3.57) (Beta-myrcene synthase TPS12) (EC 4.2.3.15) (Gamma-curcumene synthase TPS12) (EC 4.2.3.-) (Limonene synthase TPS12) (EC 4.2.3.-) (Terpinolene synthase TPS12) (EC 4.2.3.113) (G8H5M8)
Organism: Solanum habrochaites (Wild tomato) (Lycopersicon hirsutum)
Function: Sesquiterpene synthase involved in the biosynthesis of volatile compounds. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into (1E,4E,8E)-alpha-humulene and (-)-(E)-beta-caryophyllene, and of (2Z,6Z)-farnesyl diphosphate ((ZZ)-FPP) into beta-bisabolene, gamma-curcumene and (Z)-gamma-bisabolene. Can act with a low efficiency as a monoterpene synthase with geranyl diphosphate (GPP) as substrate, thus producing beta-myrcene, (E)-beta-ocimene, limonene and terpinolene.
Interaction partners:
Sequence:
MAASSADKSRPLANFSPTVWGYHFLSYTPEISSQEKHEVDELKEIFRKMLVETCDNSTQKLVLIDTIQRLGVAYHFDNEIETSIQNIFDASKQNDNDDNLHIVSLRFRLVRQQGHYMSSDVFKQFTNQDGKFKETLTNDVQGLLSLYEASHLRVRDEEILEEALTFTTTHLESIVSNLSNNNKVEVSEALTQPIRMTLPRMGARKYISIYENNDAHNHLLLKFAKLDFNMLQKLHQRELSDLTRWWKDLDFANKYPYARDRLVECYFWILGVYFEPKYSRARKMMTKVIQMASFFDDTFDAYATFDELEPFNDAIQRWDINAIDSVPPYLRHAYQALLDIYSEMEQELAKEFKSDRVYYAKYEMKKLVRAYFKEAQWLNDDNHIPKYEEHMENAMVSAGYMMGATTCLVGVDEFISQETFEWIINEPLIVRASSLIARAMDDIAGHEVEQQREHGASLIECYMKDYGVSKQEAYVKFQKEVTNGWMDINKEFFCLDVQVPKFVLERVLNFTRVINTLYKEKDEYTNSKGKFKNMIITLLVESVEI
Protein: Reduction in Cnn dots 1, isoform H (EC 3.-.-.-) (A0A0B4LFC1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKESGSVSKNQPQTSEARGSIITYSPSKFLTSVGTGRTTYSTHTHTTTATSAATTATKTNNLPMGGSSAAYYVVKAGSLGSAASMSGCIKVSSPPKGPPMAKSPALVVTSPCTPTESSSTISAPSESSFSEKMEHSYMRDTPVRSDVHNGLTPARNILVRHPPQCPSCHTYPPQHEELSEIQQAHVPPYDEVVAKEAMNECARIAKYVKNNNSDEQDWVARVNKFNWTPMQEMVFEKVCSILDQDQLARLANDKRQHEPIHRRISSDKSASRFRKLLASVAWESRITQWIHALLMEHLSPSYMASYLEILQTLKTKLPTLVDKMLFGRPLNNSQELLAPVMKKRWEPNIMPKSRQLTHNAIMVVLPNMPTTGTVSDRMQKWYQALSTITQVVQISLPNTNNRIGNQNLDHVAETIVSITRVKINELRTENPSRGIILVGFNAGAALALQVALSESVACVVCMGFAYNTIRGPRGTPDDRMLDIKAPILFVIGQNSARTSQEEMEGLRERMQSESSLVVVGSADDALRVPKSKRRIEGVTQSMVDYMVVEEIFEFVNRTLSNPPGPRMPTCLMHQQGYQRLPKQSPHILADGNANKAVQQMRKRKMDGGLDDSMGQPSKTKFVPHNRVHKPKPPRLIDPFAVKRKVGRPRTRPLPNVGGSARSVSQKDDAQDYGDAQTTAGGSASLPKVITPGVLGKQLPPVNLAAGTKIKMIPSSQFVQIKSLPSQSKLINYTLNKPSVGTSSTANIGSVVKTLPCSSVSGQQIITLKTPSGQTQQFATAATSTGAAGSSTSTGTGQKKYTVFKNANGMTMLHLTKSVPTTGSSSGSANMDLSNIIDMPIVFADNEGNIPEHQQADKDIKPAPIRSANKSPLIISQKIIKEANKPSGMVTSGSITAVSKPGNIVLNKGLQQLLNSSPGGTLATQNKVVYLNRSTIKPMGNVAPGTHRVPIRIVSTPNTGGAVTTTASSSPIMVDPATGSKVAKTVNVQTIKPTGSVLAQGTIRQAGNVGTKSYLQMINTAPGASKTVAGDGKGSVRNIYFKSATGLKQLPVQMLGNRIPGGAVISSTASASSGSPGLRRVVNIGPVSKVTATSTTSSSIAATLTHNKM
Protein: Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Q6MG60)
Organism: Rattus norvegicus (Rat)
Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O95865}. Mitochondrion {ECO:0000250|UniProtKB:O95865}. Note=Translocates from cytosol to mitochondrion upon IL1B stimulation in chondrocytes. {ECO:0000250|UniProtKB:O95865}.
Interaction partners:
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Protein arginine N-methyltransferase 1
Sequence:
MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGASHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGTTPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKVGAGLSSLCLVLSTRPHC
Protein: Redox-sensing transcriptional repressor Rex (Q97QV8)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
Interaction partners:
Sequence:
MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIGIDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLHYRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSVKSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED
Protein: Transmembrane protein 42 (Q69YG0)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- SUMO-conjugating enzyme UBC9
Sequence:
MAERPGPPGGAVSATAYPDTPAEFPPHLQAGAMRRRFWGVFNCLCAGAFGALAAASAKLAFGSEVSMGLCVLGIIVMASTNSLMWTFFSRGLSFSMSSAIASVTVTFSNILSSAFLGYVLYGECQEVLWWGGVFLILCGLTLIHRKLPPTWKPLPHKQQ
Protein: Transcription factor bHLH103 (Basic helix-loop-helix protein 103) (AtbHLH103) (bHLH 103) (Transcription factor EN 62) (bHLH transcription factor bHLH103) (Q8VZ22)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Lysine-specific demethylase JMJ28
- Subtilisin-like protease SBT3.1
- Tubby-like F-box protein 11
Sequence:
MTEEFDTTGVCTGTWWSSSNGMFSGCSLPRSAEIVVDFGEIEWQNIDTLDAKTYNENYLSTSTFLGNANLDTTSQIYVSSPSNIHEEERYNQINSFLEGLFDSSEQLLVPNCPKPELFESFHFFDDVFPNESRMISVFDHQKPKEDMQACKSLTTCKRASEKSGELEDIESSQPLKRPRLETPSHFPSFKVRKEKLGDRITALQQLVSPFGKTDTASVLHDAIDYIKFLQEQITEKVSTSPHLNSIGSGEQKQWSDKSSNNTHNQNCSPRQDLRSRGLCLMPISSTFSTPPQHLDTSSLWN
Protein: Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit) (P61008)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:3511473, ECO:0000269|PubMed:8444896}; Single-pass type II membrane protein {ECO:0000269|PubMed:8444896}.
Interaction partners:
- Signal peptidase complex subunit 1.
- Signal peptidase complex subunit 2
- Signal peptidase complex catalytic subunit SEC11C
- Signal peptidase complex catalytic subunit SEC11A
- Actin-related protein 2/3 complex subunit 5
- Uncharacterized protein.
- Uncharacterized protein.
- FCH domain only 1.
- Epidermal growth factor receptor pathway substrate 15 like 1.
- Mitochondrial ribosomal protein S18B.
Sequence:
MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY
Protein: Chromo domain-containing protein (A0A0K3AR81)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPSSSETLQLFPHEGRGKKCETQVNVDTEEEGSDRTLEESEDEQEGEEDEEDEELDDDLWIVEKIQKMRYNGKLKRVEFLVLWEADKSKSWEPIENFHSGYDNVEIERFRTENPEQFDDVTDKSTATKKKGRPKKLQKRITKDIDDEPDETAQGESKRLADPNKLQDPSEKTPRKTKLRDGKIIDSNDQKQEVSSRKWSVGRSKKRPPTQMAENETSSCMKPREKSTRSQAEVYLPPLKRSRSKCQVSAPQPSNSSLQLSQCISESVPRRSRTRCRTTSDTTIEEDSMIALSDPKNHNFMQNKNTASGSRNKSTSQMGRSQSKASDDVIISEVSPIVTRRSRSRSHVSSLMENPPPLTRSRSIPQKATTIPTTRSRSRGRFELSGNSGAEIRIERNLPRPVEQSSSRHGQSQSEAIIVSEVSSRRSRSRCRVASLKETPPSLSTTRSKPIQQEKSIRHPRSRSRSRVVLSENSCAEIIKKRNPPRSKSVVGRPQSNNEDEKKKNQKVPTRVRSKSVSYEISKLVPNRHVSRVPPDFYEMQILWTQISEKTTPTELSEYKSGLQKLLTGRVSCLKPIFQLLPTLPIELYETHEKLYSLFCEITGAFPFKYHQGSNLISRHSIADKSQIGAQILLECLSQNILPFDVVNDQTTLLAIHNFIRIGIKDMLEDIVEKLPKGRNVITENDLQGSLSSKLLG
Protein: FANCD2 (D3YT99)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLMMPSKSTEKEATRFEIDEIISRFLLSVSDREKFLGLLALLMKIQVEMGKKHSENQEHLVREGISRCEEAVKSSSALRGAFYEHMRIVLQQHKRTEEIRFLSDWSTDLLKRFKNDFFELPPNPESNTDPDSQSTWNLKLNSARLLEIAPMFELIKEIQVLKMRWREEDQDSLTSSYDISVIKNLSFAFEAVLPKDENLPLNRQEKLAQLFFNVQWTRTVLNGFLSQSSVDFLSSDDVSTLSIKNFYVMMDAEKKLAASLVDLATWNVPNLNFGRSGKRDVIVISSEKTKSKKGRKRKSDETTVIGGDGQTNSADVTVNDDDREENLEAEVVKEAPSVLLQLKSHYIPLKLRPIVHLMKLANKKRSALKYLCDELQSVIDTLIKQKKKTPPMLLAARRAAAPTTPNSSKFYHGDSVTIWFCVKKAVEQVWGIVELVFGVFAEQSDASQELKSRVQKDMDDLGEKSLNLIHSILSGELYGGEEKLSPAERVERKSVLIRIIEKKMLSSEHLSNDSEKARVEIGKFLAKSAEFSPTPAVAVAILDVFEDLKLDEDDDAETRKIMAKYALAYLKKDWSKVDELWSKGTRYTCAVRDILHHYIRLRKEKDQLLAIQWILTNKVVQLVPEDDKRKSCVFSQQSDDDLLEKEDRKATFYCISKTTFGVIFKTLFGNLNSRCLKYDMSASAAKNGGVDIEDTLESWETASSCFLILCLLLRINKIRTTAVLTSAIKEGKQFLITVSKKSSFIFLMDNITKGTNFDTICRRVEKILSAVQQGNRVLQSIGTFAKTNKCVLLLKKFPELRAESENCLRVIHSAMVKNECLNAFTVGLVKSRSIDGDIIMDQRASEIDSDSE
Protein: Protein delta homolog 2 (DLK-2) (Epidermal growth factor-like protein 9) (EGF-like protein 9) (Q6UY11)
Organism: Homo sapiens (Human)
Function: Regulates adipogenesis.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEAGLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQVSMLPAGLPLPRDLPPEPGKTTAL