wanglab/gogpt-training-data huggingface dataset:
Protein: Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A) (Q9NPD3)
Organism: Homo sapiens (Human)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:36912080}. Nucleus, nucleolus {ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:36912080}. Nucleus {ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:36912080}. Nucleus, nucleoplasm {ECO:0000269|PubMed:36912080}.
Interaction partners:
- Exosome complex component RRP40
- Exosome complex component RRP4
- M-phase phosphoprotein 6
- Exosome complex component CSL4
- Exosome complex exonuclease RRP44
- Exosome complex component 10
- Exosome complex component RRP45
- Exosome complex component MTR3
- Exosome complex component RRP46
- Exosome complex component RRP43
Sequence:
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEIRGSRARALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREASILLGD
Protein: Elicitin (O42718)
Organism: Phytophthora infestans (Potato late blight agent) (Botrytis infestans)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU368111}.
Interaction partners:
Sequence:
MNTKTFLAIAAAAFVGFAAAETCSPTDQTTAYSTLASVLTLSSFQGCADDSGFSLLYSTALPDDDQYVKMCASDNCKSLIESVASLNPPNCDLTVPTSGLVLNVVDLTSGFSEKCSSSSSTSNTASSAATSTTTEAPAATTAAPTTDTTTASTATDAPAATPVATPATTTTNSTESVTQTSAAAC
Protein: 3'(2'),5'-bisphosphate nucleotidase (EC 3.1.3.7) (Q8VWZ6)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
LDPIDGTKGFLRGDQYAIALALLDGGKVVLGVLACQNLPLTSLSDAGQHSPNNKVGCLFFAVVGGGTYMQPLDGSSAVKVQVSAVENPEEASFFESYEAAHSMHDLSSLIAQKLGVKAPPVRIDSQAKYGALSRGDGAIYLRLPHKGYREKIWDHAAGCIVVSEAGGVAQMLQAAIGFFKGKYLDLDTGIIVTNQKLMPLLFNAVRKSIQEKASSL
Protein: Mucin-21 (MUC-21) (Epiglycanin) (Q5SSG8)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000269|PubMed:17977904}; Single-pass type I membrane protein {ECO:0000269|PubMed:17977904}; Extracellular side {ECO:0000269|PubMed:17977904}.
Interaction partners:
- Mucin-13
- Mucin-20
- Mucin-15
- Mucin-4
- Mucin-12
- Mucin-3A
- Mucin-7
- Mucin-17
- Mucin-19
- Mucin-5B
Sequence:
MKMQKGNVLLMFGLLLHLEAATNSNETSTSANTGSSVISSGASTATNSGSSVTSSGVSTATISGSSVTSNGVSIVTNSEFHTTSSGISTATNSEFSTVSSGISIATNSESSTTSSGASTATNSESSTPSSGASTATNSDSSTTSSGASTATNSDSSTTSSEASTATNSESSTTSSGASTATNSESSTVSSRASTATNSESSTTSSGASTATNSESRTTSNGAGTATNSESSTTSSGASTATNSESSTPSSGAGTATNSESSTTSSGAGTATNSESSTVSSGISTVTNSESSTPSSGANTATNSESSTTSSGANTATNSDSSTTSSGASTATNSESSTTSSGASTATNSESSTTSSGASTATNSGSSTTSSGTSTATNSESSTVSSGASTATTSESSTTSSGASTATNSESSTVSSGASTATNSESSTTSSGANTATNSGSSVTSAGSGTAALTGMHTTSHSASTAVSEAKPGGSLVPWEIFLITLVSVVAAVGLFAGLFFCVRNSLSLRNTFNTAVYHPHGLNHGLGPGPGGNHGAPHRPRWSPNWFWRRPVSSIAMEMSGRNSGP
Protein: Uncharacterized protein (Q8BUK9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MELASSEEVQMQLGRSQERRAHVDHLHQLALTLGVDIISSVQQPNCSNISAKNLQQQLEALELESRSWSAQAKEHERVLSCSLEYCTARDEISELKESFKDIKKKFNNLKFNYS
Protein: Nucleolar protein NET1 (P47035)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has a role in chromosome maintenance and is involved in mitotic exit. Inhibits the action of CDC14 by sequestering it in the nucleolus. Also binds to RNA polymerase I and stimulates rRNA synthesis. Influences RDNA chromatin by tethering SIR2 to rDNA in the nucleolus.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12056824}.
Interaction partners:
- DBF2 kinase activator protein MOB1
- Protein phosphatase PP2A regulatory subunit B
- Cell cycle protein kinase DBF2
- Cell division control protein 15
- NAD-dependent histone deacetylase SIR2
- DNA replication fork-blocking protein FOB1
- Protein TEM1
- Tyrosine-protein phosphatase CDC14
- G2/mitotic-specific cyclin-2
- Mitosis inhibitor protein kinase SWE1
Sequence:
MYKLQVVLVPPSLQATMPIQFGYGPTIAESSQLLPNRTNMAQSAGDASLQYANLRSANVSFTPSYFNQSRFRKFLLFTKPTNTLLNLSDEIIDKCEKMYPSLQEDIEILSLQDNSGCDLDPDFLVKDVFNVNNIVRVILKNEIDLDDSAPVSLYKSVKRSKLNNGSPQSVQPQQQIPSSSGVLRIAKKRPPTGTTTTTTIRSATNGSMRVSTPLARQIYPPPSSKIVSNNSDDEDEDIGERSFLPPPTQPQSPPIRISSGIDAGKKIKSSIVEEDIVSRSATVDPDKTKQQRLLSGTPIMSTMTPNRVTLTGQRVVSEHAHKNELVFSASASSSSFANGGTAAVTAQDINRKPPVTTPRITSGMLKIPEPRISEIEKELKEGPSSPASILPAKAAKIPMKKPYLENGENYESDDSSSSENQETPETEPHSKASLQRSQSSIADNNGSPVKNSPLGDAMPHNVHLAELPKASNTSITKSSNGESWGKQQEHQPPRKSSLETIVEKKSQAEPSGIVEPKRMTNFLDDNQVREKEDTNDKLLEKEILPTIPHNDQPILASSDKSNGTLKSLAGKVSSNNNASKEDGTIINGTIEDDGNDNDEVDTTVRIVPQDSDSSSFPKSDLFKMIEGDDTDLPQWFKGKNSRTSGNSKNSKPYTTVLNKDIDNSKPDPRNILPQRTPRSAAKRAAQLLAGAKKNEVPQKSTEDSSSAASTDDESESGIETDFSSDDDFKRKNMSVPNNGPKDISLHSLKGSVVPVKDSKIINKEVDEERNDKRDSQKKSAVSESSVTNSKISEQMAKSFYPNSNKKQNEATKVETKPATQASSFPVVGGSPSVATKGTTSFNEEGNRKNVKTKAKNESAQIDRQQKETTSRVADLKSANIGGEDLNKKAEGSKEPEKASANIQDANDKNNSKEKEDSKSKQVSQKKLKMTDHLKEGNVQLPKPSANDKLKDLKAKFTNSKTLVPPGIISNEKNNSSANDDDSSSSGSSTEDESSSSSSSSDEETSTSRKARRVVVNTPREPVRSSSKIEAPSPSVNKKINATPDKIPVTQLMDMSSPPSVKSKTTSNPSSILHDLPRKVRPSLSSLSDLVSRGIPDVKEKTSKSNEKSQTKAPSSSDDESSSDSDSNSSSDSVSDSSSDSKSESDSDDSGDSSDDGKSFISAKSASAALGKKKKPSGGFASLIKDFKKK
Protein: Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) (V9HVZ4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
Protein: CD164 molecule, sialomucin (Sialomucin core protein 24 precursor) (Q5TZ44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MFWRLFAVTLLLALLGSMTSQQFSADEVCSTFHGCDACENVTLCQWMNCTDGFQCVNSSHENQTANCVSANCTEPPVASTVNPVTTSSTNATTNATTVIPTIPVTPTRNGTDTNSTTTASPTTAPSKTSTFDAASFIGGIVLVLGLQAVIFFLYKFCKSKDRNYHTL
Protein: Splicing factor YJU2 (A8MR03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|HAMAP-Rule:MF_03226}.
Interaction partners:
- Sm protein F
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7
- Pre-mRNA-splicing factor SYF2
- At2g44200/F6E13.34
- Pre-mRNA-splicing factor 18
- Pre-mRNA splicing factor domain-containing protein
- Probable small nuclear ribonucleoprotein F
- Cell division cycle 5-like protein
- Tetratricopeptide repeat
- Polyadenylate-binding protein RBP45C
Sequence:
MGERKVLNKYYPPDFDPAKLQRLRRPKNQQIKVRMMLPMSVRCGTCGNYIYKGTKFNSRKEDVIGENFSFDVQTYLGIQIFRFYFKCTKCSAELTMKTDPQNSDYIVESGASRNYEPWRAEDEEVDKDKQKRDAEEMGDAMKSLENRTLDSKREMDIIAALDEMKSMKSRHATVSVDAMLEALQRTGAEKVKRIEEEDEAVIKSIFGKQKEVIRRIADEEIDDDYDDDDIDDYPSLQKEKKGSSSDLSKKRKATEVSPSNPTDILTSSSAENPKEPKKQAISKQPFKSVHIKVIKKQPQPTSSSTPAPAKPEEKKSDGAANTSLASLFQNYGSDEDED
Protein: P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) (Q64663)
Organism: Rattus norvegicus (Rat)
Function: Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q99572}; Multi-pass membrane protein {ECO:0000269|PubMed:31587896, ECO:0000269|PubMed:39107314}.
Interaction partners:
- Pannexin-1
- P2X purinoceptor 1
- NACHT, LRR and PYD domains-containing protein 3
- Caspase-1
- P2Y purinoceptor 2
- P2Y purinoceptor 6
- P2X purinoceptor 2
- P2Y purinoceptor 1
- P2X purinoceptor 3
- P2X purinoceptor 4
Sequence:
MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISSVHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCPEYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPALLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGENFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYKENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYASTCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKSLQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCGNCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEAINSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
Protein: Regulator of DNA class I crossover intermediates 1 (Q86WS4)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000250|UniProtKB:A0A087WRU1}. Note=In pachytene spermatocytes, localized along autosomal axes and the synapsed pseudoautosomal region on sex chromosomes, decreasing rapidly after early pachytene, by mid- or late pachytene, and disappearing in the diplotene stage. Also detected on the paired regions of homologous chromosomes in zygotene and pachytene oocytes, colocalizing with MSH4. Chromosomal localization of REDIC1 is mainly dependent on meiotic DNA double-strand breaks (DSBs) and interhomolog strand invasion. In spermatocytes from early zygotene to early pachytene, more than 90% of REDIC1 foci colocalize with RPA2. Probably localizes first to recombination intermediates and later colocalizes with MLH1 at crossover sites. {ECO:0000250|UniProtKB:A0A087WRU1}.
Interaction partners:
Sequence:
MNWVGGSRSRVLIKQERRKQKEYFEKHRLKSKMKSLGVLSPVKNSAVSLDILNLYMVNQISCKKKIPETVRKPTHVNMNRDIKMPLRKHNLELTMSPHCVPSKLCLDDTETNVNCQRLSSKEDLGPVQSQGMDSYSMLHPQFSKIENCSFTPSSFSVELPSNRHISKLNFTSGIAPTPQKLAYEKKQNDQRSTVNCSDSLLSKLNKSQDVFSPSHKTTRFGTLFERLNSLGNRNLLTKSPAVIMDEDCRSTDEIRQSDYITEKHSIQHIWGKNGKEVSNFLEDVNQSTPNLLSENCDSFVSQNMINVLNIDEQRIKKTFNKCDYDSMGDTCVVTSSDKNHVTDRCIRNIFTVPELTFSNSTLNKTSYPEKCQPNKKYQREYNKNERNDLSTSFENDYYPSSSERKEKFENDYQEKTPQKSIQKYPANSMGNIPSEELHSKQSWDFGLDEILMEEGGIYSLKSKRISTKKISLDSAQSSRSTSYSPRPTDSCFSSSSDLPSEDEDQISQQIEDSNRMTIKTKEKMNNFYVERMAKLSGDRIVKNDDKIHKQNENFYQFSVKNNTDQFPQLQCNSAHILQNKTNDNCVLQAARCDAGIQTESESVMEEKLDVAIQCDLISKCTCRSDVSLCNLERCSGNIKADTTGGQEIHKNN
Protein: AP-1 complex subunit sigma-1 (Sigma1-adaptin) (Valproic acid-sensitive protein 2) (Q9P7N2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the AP-1 complex which links clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:19624755, ECO:0000305}. Endosome {ECO:0000269|PubMed:19624755}. Golgi apparatus {ECO:0000269|PubMed:19624755}.
Interaction partners:
- AP-1 complex subunit mu-1
- AP-1 complex subunit gamma-1
- AP-1 complex subunit beta-1
- AP-2 complex subunit beta
- AP-2 complex subunit alpha
- Repressor of RNA polymerase III transcription maf1
- AP-3 complex subunit delta
- Valine--tRNA ligase, mitochondrial
- Uncharacterized transcriptional regulatory protein C965.10
- AP-3 complex subunit beta
Sequence:
MSIKFFLLVSRQGKVRLAKWFNTLSIKERAKIIRDVSSLVITRKPKMCNFVEYKGEKIVYRRYASLFFVCGIEQDDNELIILEVIHKFVECLDKYFGNVCELDLIFNFEKAYYVMEELLLAGELQESSKTNVLSAVLAGDAESEADAQQDSLQKLVGSVKKR
Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (Q8IPC3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
Interaction partners:
Sequence:
MNIYQQKLSSDSDIHNNIPLTVLEFYSPNLLPEELGFTIADYQPLIEIPGTELAIGSLVEVSNPGVCEDLYGVVRWIGIPPGPQKNVLVGIEVEDESNLKNVVASDGRHNGVRLFTCHDGRAIFVPANRCTADRRFADVDNSISANRVSSNHAKKFGVADCPAIYGSIPPLQIHNSDELASICGKFKGIQGHHNSCYLDATLFSMFTFTSVFDSILYRRPGPQDIRNYSEVQKVLRDEIVNPLRKNVFVRSDRVMKLRELLDQLSSVSGLTCEEKDPEEFLNSLLSQIMRVEPFLKLSSGQDSYFYQLFVEKDEKLTLPSVQQLFEQSFHSSDIKLKEVPSCFIIQMPRFGKNYKMYPRILPSQVLDVTDIIENSPRQCSLCGKLAEYECRDCFGSLQAGSGLECTAFCPKCLKTFHSHIKRTNHVSKKIYSPKEFKIMAEHMVVPRLYMELFAVVCIETSHYVAFVKSGSGPDAPWCFFDSMADRKGEQNGYNIPEITCVPELTQWLSEEGARSINETSTNDKVLPEHAKRIFCDAYMCLYQSTDIMMYH
Protein: F-box involved in polyQ pathogenesis, isoform A (Q9VAK7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Crystallin, isoform A
- GEO01111p1
- Cullin homolog 1
- Protein cycle
- Circadian locomoter output cycles protein kaput
- S-phase kinase-associated protein 2
- GEO01805p1
- Cryptochrome-1
Sequence:
MDISTDIWGQLAVEASQVYLSDGTVRSPFADTTIEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWKNVSLRPEVSGLHVGSLEMLLQLISVRFGPTLRYIELPIELITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKLRYMCVCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIYEVINVHKLKSATPNLRVINLYGINFIDDSHIDAFSSNCIQLECLAVNFCNKVTGSTLKTLIQRSKRLTCLLMNGTSLKSEFVMQAEWDKCALQELDITATDLSTECLVDMLSRIPSLKFLSAGQINGFNDSVLKQWMESGTTRSLISLDLDSSDNISDEGLLKFIQRQGHQLSACCLSGMPHITDQLWMSILPLLGNCKIIVMGTAEKLGVNIHVDQLMDTIASNCGNLERLELRWDPDNLRFSDKSQKAIDILRVKCLKLRCMVLSDGRYYETVKANFERADRITVVRTTTCCRVSPYHLLRNYNDLIFN
Protein: Serine/threonine-protein phosphatase BSL1 (EC 3.1.3.16) (BSU1-like protein 1) (Q8L7U5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphatase involved in elongation process, probably by acting as a regulator of brassinolide signaling.
Subcellular location: Nucleus {ECO:0000269|PubMed:19245862}.
Interaction partners:
- UPF0235 protein At5g63440
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- WW domain-containing protein
- AT5g16210/T21H19_130
- Serine/threonine-protein kinase BSK1
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- Cysteine proteinase RD21A
- Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Sequence:
MGSKPWLHPAPQYKTLETFWDDEDDAPGPRCAHTLTAVAATKTHGPRLILFGGATAIEGGSSSVPGIRLAGVTNTVHSYDILTRKWTRLKPAGEPPSPRAAHAAAAVGTMVVFQGGIGPAGHSTDDLYVLDMTNDKFKWHRVVVQGDGPGPRYGHVMDLVSQRYLVTVTGNDGKRALSDAWALDTAQKPYVWQRLNPDGDRPSARMYASGSARSDGMFLLCGGRDTLGAPLGDAYGLLMHRNGQWEWTLAPGVAPSPRYQHAAVFVGARLHVSGGVLRGGRVIDAEASVAVLDTAAGVWLDRNGQVTSARGSKGQIDQDPSFELMRRCRHGAASVGIRIYVHGGLRGDVLLDDFLVAENSTFQSDISSPLLASDRTQQSSTPRFSYAARPPSGSEPSFSMSEGLSLDENSLEKLTEASAAEAEVASSVWRAAQLGAGTLDEEPSTSDASSPIVESTTDGTANEGDVRLHPRAVVVAKETVGSLGGMVRQLSLDQFQNESRRMVPMNNSDVPQPTKKFTRQKSPQGLHKKVIAALLRPRNWKPPGNRKFFLDSYEVGELCYAAEQIFMHEQTVLQLKAPIKVFGDLHGQFGDLMRLFDEYGFPSTAGDITYIDYLFLGDYVDRGQHSLETITLLLALKIEYPENVHLIRGNHEAADINALFGFRLECIERMGENDGIWAWTRFNQLFNYLPLAALIENKIICMHGGIGRSISTVEQIEKIERPITMDAGSLVLMDLLWSDPTENDSIEGLRPNARGPGLVTFGPDRVTEFCKRNKLQLIIRAHECVMDGFERFAQGQLITLFSATNYCGTANNAGAILVVGRGLVIVPKLIHPLPPPILSPENSPEHSGDDAWMQELNIQRPPTPTRGRPQPDFDRSSLAYI
Protein: Galanin-like peptide (Q9QXQ6)
Organism: Rattus norvegicus (Rat)
Function: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Serine/threonine-protein kinase A-Raf
- Galanin receptor type 2
- Galanin receptor type 1
- Galanin peptides
- Galanin receptor type 3
- Heterogeneous nuclear ribonucleoprotein U-like protein 2
Sequence:
MACSKHLVLFLTILLSLAETPDSAPAHRGRGGWTLNSAGYLLGPVLHLSSKANQGRKTDSALEILDLWKAIDGLPYSRSPRMTKRSMGETFVKPRTGDLRIVDKNVPDEEATLNL
Protein: Aminopeptidase (EC 3.4.11.-) (E9PLK3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDAESIHQYLLQRKASPPTV
Protein: Homeobox protein MOX-1 (Mesenchyme homeobox 1) (Protein choker) (F1Q4R9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by mediating specification of endothelial cells of the endotome within the nascent somite, notably by repressing expression of cxcl12b.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the nucleus. {ECO:0000250|UniProtKB:P32442}.
Interaction partners:
- T-box transcription factor TBX6L
- T-box transcription factor TBX6
- Transcription factor 15.
Sequence:
MEQSASSCMRSPHTGGALWGCVRSPHSGGSGAGIQPYQQAPFALHQKHDFLAYTDFSSSCLVPAPHAYPREDRLYPETHSGYQRTEWQFSPCEPRGRGQEPCQGAAEAVGAEMDSAGGDRLAGAVTGCLEGDYSPQSVPAVDTEKKSSKRKREVTDIQDSSFKADSNCKARKERTAFTKEQLRELEAEFTHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQPASPHDLEADELDSAASPSSE
Protein: Golgin candidate 1 (AtGC1) (Golgin-84) (Q8S8N9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18182439}; Single-pass type II membrane protein {ECO:0000269|PubMed:18182439}. Note=Probably located to cisternal rims of cis or medial Golgi.
Interaction partners:
- Golgin candidate 3
- Golgin
- Golgin candidate 6
- Golgin candidate 4
- Epimerase family protein SDR39U1 homolog, chloroplastic
- At1g21930
- Golgin candidate 5
- Wax ester synthase/diacylglycerol acyltransferase 11
- Conserved oligomeric Golgi complex subunit 3
- At4g19400
Sequence:
MASWLKAAEDLFEVVDRRAKSVVEDLSEEQNDLQLPASGRKGSQGKRTSSKKKKLVKEESSNKRDSSGDQSGPGVSQSEVPPSKSSVSTDETSSSGPVLLTREIHPTDADVQSVLSLPLSVADTKSDDAAVVAQESIVDGDRSESKHADGDIPNDSLVQPSPSLPDKEIEVVVSENLMDAPKNGTQRELDDSSKRDVENLDSVVHAPSVNEGNVAQSTGDEVKVGTSINLEKEQEPKVPVTSTNLKREQDRRADTTSMKIQDQLEEAQGLLKATVSTGQSKEARLARVCAGLSSRLQEIKAENAQLEELLTAEQELTKSYEASIRHLQKDLSAAKSEVTKVESSMVEALAAKNSEIETLVSAMDALKNQAALNEGKLSSLQGDMESIMRNRELAETRMMQALREELATTERRAEEERSAHNATKMAAMERERELEHRAVDASTALVRIQRIADERTAKVADFEQKVALLEAECTSLNQELQDMEVRARRGQKKAPDEANQVIQIQAWQDEVDRARQGQRDAEEKLSLMEAEMQKLRVEMAAMKRDAEHYSRQEHTELEKRYRELTDLLYYKQTQLETMASEKAAAEFQLEKEVKRLHEAQVEVEKSRVSRRASATWEEDSEIKTLEPLPLYHRHMATASTQLQNAVKLLDSGAVRATRFLWRYPIARMFLLFYLVFVHLFLMYLIHRLQEQAEAQEVAAMTNNVFRL
Protein: Peroxiredoxin-2 (EC 1.11.1.24) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) (P35704)
Organism: Rattus norvegicus (Rat)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P32119}.
Interaction partners:
- Thioredoxin
- Peroxiredoxin-5, mitochondrial
- Glutathione peroxidase 1
- Sulfiredoxin-1
- Parkinson disease protein 7 homolog
- Superoxide dismutase
- Glutathione peroxidase 3
- Thioredoxin reductase 1, cytoplasmic
- Phosphatidylethanolamine-binding protein 1
- Glutathione peroxidase
Sequence:
MASGNAHIGKPAPDFTGTAVVDGAFKEIKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN