wanglab/gogpt-training-data huggingface dataset:
Protein: Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA) (Q90669)
Organism: Gallus gallus (Chicken)
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P27038}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Bone morphogenetic protein 4
- Bone morphogenetic protein 7.
- Bone morphogenetic protein 6.
- Growth differentiation factor 11.
- Inhibin beta B chain
- Growth differentiation factor 7.
- Activin receptor type-1
- Bone morphogenetic protein 2
- BMP5
- Inhibin alpha chain
Sequence:
MGAATKLAFAVFLISCSSGAILGRSETQECIYYNANWEKDKTNRSGIEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRNDCIEKKDSPEVFFCCCEGNMCNERFFYFPEMEVTQPTSNPVTPKPPLFNTLLYSLVPIMGIAVIVLFSFWMYRHHKLAYPPVLVPTQDPGPPPPSPLMGLKPLQLLEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEIYSLPGMKHDNILQFIGAEKRGTSIDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAQTMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTASDGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRECWQKHSGMAMLCETIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTEDIVTVVTMVTNVDFPPKESSL
Protein: Sodium/potassium-transporting ATPase subunit beta (Q91580)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}. Membrane {ECO:0000256|RuleBase:RU362099}.
Interaction partners:
- FXYD domain-containing ion transport regulator
- FXYD domain-containing ion transport regulator
- Sodium/potassium-transporting ATPase subunit alpha
- Cation_ATPase_N domain-containing protein
- Sodium/potassium-transporting ATPase subunit alpha
- Sodium/potassium-transporting ATPase subunit alpha
- FXYD domain-containing ion transport regulator
- FXYD domain-containing ion transport regulator
- Sodium/potassium-transporting ATPase subunit alpha.
- Sodium/potassium-transporting ATPase subunit alpha.
Sequence:
MARDKAKETDGGWRKFIWNADKKEFLGRTGGSWFKILLFYLIFYGCLAGIFIGTIQVLLLTISEFEPKYQDRVAPPGLTQLPRAVKTEISFSPSDSNSYQEYVKSMDNFLSKYNNEKQGSNMFEDCGTIPGPYHERGALNKDEGMKKSCVFRREWLQNCSGLNDPSYGFADGKPCVIVKLNRILAFKPVPPQNNSLPPEMTLNYNPYVIPIHCQAKKEEDIEKIKEVKYYGMGGFAGFPLTYYPYYGKLLQPDYLQPLIAVQFTNITFDAEVRIECKAYGENIDYHDKDRFQGRFDVKFDIKSS
Protein: Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 (Polypeptide GalNAc transferase 15) (GalNAc-T15) (pp-GaNTase 15) (Protein-UDP acetylgalactosaminyltransferase 15) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15) (Q7Z4T8)
Organism: Homo sapiens (Human)
Function: Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region.
Subcellular location: Late endosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (By similarity). {ECO:0000250}.
Interaction partners:
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- C1GALT1-specific chaperone 1
Sequence:
MRNAIIQGLFYGSLTFGIWTALLFIYLHHNHVSSWQKKSQEPLSAWSPGKKVHQQIIYGSEQIPKPHVIVKRTDEDKAKSMLGTDFNHTNPELHKELLKYGFNVIISRSLGIEREVPDTRSKMCLQKHYPARLPTASIVICFYNEECNALFQTMSSVTNLTPHYFLEEIILVDDMSKVDDLKEKLDYHLETFRGKVKIIRNKKREGLIRARLIGASHASGDVLVFLDSHCEVNRVWLEPLLHAIAKDPKMVVCPLIDVIDDRTLEYKPSPLVRGTFDWNLQFKWDNVFSYEMDGPEGSTKPIRSPAMSGGIFAIRRHYFNEIGQYDKDMDFWGRENLELSLRIWMCGGQLFIIPCSRVGHISKKQTGKPSTIISAMTHNYLRLVHVWLDEYKEQFFLRKPGLKYVTYGNIRERVELRKRLGCKSFQWYLDNVFPELEASVNSL
Protein: Defensin-like protein 266 (Q2V4F0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MEKIVFRKIVFVAFLLSLSCLLEGEARMSGDVTIQRGGSCNNDNTCHDTCPGCRITQCIFRQCVCTRCNTPRSSLRIESHM
Protein: Alpha-tubulin N-acetyltransferase (Alpha-TAT) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) (Q57XX3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Interaction partners:
Sequence:
MTHNVMCDDVLPQLNLPDGVTRWNANLLEEERRLRNSDGHADRIILTINTLGKRSKEAQSLNTILTSVPRLRENRDARLYLLCHGGRGVGILKIGVKRLFVVPPSHAGLMEIEPVCVLDFFVDTSNQRQGYGKILFEHMLAFERLSPGDVAIDRPSVKFLAFLRKHYGLVEYTPQSNNFVVFHKYFERHQQQRRGVGGSGRSGYQHCNETTTQQLGTQSGLLEDINQTHPAPSYALRGVVMGHTGPPLDLTNVTQQQKPYHQPFATGRKTSYELQYERYLQSQNCRPTGNAGYGGGNGPASSAEVRATNCQARRRTSPTRSGVPYNIINGSTGS
Protein: GH01077p (Ubiquinol-cytochrome c reductase core protein 1, isoform A (EC 3.4.24.-)) (Ubiquinol-cytochrome c reductase core protein 1, isoform B) (Q9VFF0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Cytochrome b-c1 complex subunit 8
- Cytochrome b-c1 complex subunit 6
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- AT02348p
- Cytochrome b-c1 complex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Mitochondrial-processing peptidase subunit alpha
- Cytochrome b-c1 complex subunit 9
Sequence:
MALRVLGVTQNMRSFMRGVDMIKRYKSAATLQKTLLNIPATQVTKLDNGLRVASEDSGASTATVGLWIDAGSRSENEKNNGVAHFLEHMAFKGTAKRSQTDLELEVENLGAHLNAYTSREQTVFYAKCLSKDVPKAVEILADIIQNSKLGEAEIARERSVILREMQEVESNLQEVVFDHLHATAYQGTPLGQTILGPTKNIQSIGKADLTDYIQTHYKASRIVLAAAGGVKHDDLVKLACSSLGGLEASVLPAEVTPCRFTGSEVRVRDDSLPLAHVAIAVEGCGWTDQDNIPLMVANTLVGAWDRSQGGGANNASNLARASAEDNLCHSFQSFNTCYKDTGLWGIYFVCDPLQCEDMLFNVQTEWMRLCTMVTEAEVERAKNLLKTNMLLQLDGTTPICEDIGRQILCYNRRIPLHELEQRIDAVSVGNVRDVAMKYIYDRCPAVAAVGPVENLPDYNRIRSSMYWLRV
Protein: Cell adhesion molecule-related/down-regulated by oncogenes (O35158)
Organism: Rattus norvegicus (Rat)
Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:21802063, ECO:0000269|PubMed:9214393}; Single-pass membrane protein {ECO:0000269|PubMed:21802063, ECO:0000269|PubMed:9214393}.
Interaction partners:
- Sonic hedgehog protein
- Patched
- Hedgehog protein
- Hedgehog protein
- Growth arrest-specific 1.
- Brother of CDO
- Low-density lipoprotein receptor-related protein 2
- Protein smoothened
- Patched 2
- Cadherin-15
Sequence:
MHPDLGPLWKLLYVLVILCSSVSSDLATYFISEPLSAVQKLGRPVVLHCSAKPVTARISWLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSVGAVVSGPATVSADALADFDSSTMHVITAEKKNTGFIGCRVPESNPKAEVRYKIRGKWLMYSTGNYIILPSGNLQILNVSSKDKGSYKCAAYNPVTSELKVEPAGRKLLVSRPSSDGFHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDCLSGSNWRRLYSHLATASIDPADSGNYSCVVGNNSSGDVKHVTYTVNVLEHASISKGLHDQKVSLGATVRFTCEVHGNPAPNRTWFHNAQPIRPSSRHLTEGSVLKITGVIMEDSGLYQCMADNGIGFMQSTGRLQIEQDSGQRPVIVTAPANVEVTDGDFVTLSCNATGEPVPVIHWYGRHGLITSHPSQVLRSKSRKSHLFRPGDLDPEPVYLIMSQAGSSSLSIQAVTREHAGKYTCEAVNKHGSTQSEAFLTVVPFETNTKAEPVTPSEASQNDERDPRDGSESGLLNLFPVKVHSGGVELPAEKNASVPDAPNILSPPQTHMPDTYTLVWRTGRDGGMPINAYFVKYRKLDDGSGAVGSWHTVRVPGSESELHLTELEPSSLYEVLMVARSAVGEGQPAMLTFRTSKEKMASSKNTQASFPPVGIPKRPVTSEASNSNFGVVLTDSSRHSGVPEAPDRPTISMASETSVYVTWIPRANGGSPITAFKVEYKRMKSSDWLVAAEDIPPSKLSVEVRSLEPGSIYKFRVIVINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPMKELSTPPSSSGNGGNVGPATSPARSSDMLYLIVGCVLGVMVLILLVFIALCLWKSRQQSAIQKYDPPGYLYQGSEINGQMVEYTTLSGTARINGSVHGGFLSKGSLSNGCSHLHHKGPNGVNGILNGTINGGLYSAHTSSLTRTCVEFEHPHHLVNGGAVYTAVPQMDPLECINCRNCRNNNRCFTKTNSPLPVVPVVASYPQDGLEMKPLGVMKFPVCPVSTVPDGGQIPEECLKDSVAPAPTQRTCRQDNTSDINSDSTEDTAEFNRGDSSGHSEAEDKVFSWSPLILSPVLEDCSEKTAWSPPGPPLDGLSVVLQQAQET
Protein: peptidyl-tRNA hydrolase (EC 3.1.1.29) (Q582G7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTPLGFDFTSFVLSFGTGVFVALFLMRWGCPFQFSVRSKMRQANAFACCGEPLKMTLVVRRDLKMGTGKIAAQCAHAAVAVMEEVQSRRSDNGANCNDSCSTYGYSGNSDHYSPAASQMCGGSGADKWVSWYDAWRFAGSKKVALQCENEEQLMEAYRAARREGIPHAVIRDAGRTQIAAGSKTVLAVGPAPDSLVDRVTGHFKLL
Protein: Excitatory amino acid transporter (Q94AL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g67350
- At4g16450
- Uncharacterized protein At2g27730
- Gamma carbonic anhydrase-like 2, mitochondrial
- Gamma carbonic anhydrase 1, mitochondrial
- 2Fe-2S ferredoxin-like superfamily protein
- NADH dehydrogenase 1 beta subcomplex subunit 2
- NADH dehydrogenase 1 alpha subcomplex subunit 1
- Transmembrane protein
- NADH dehydrogenase iron-sulfur protein 5-A
Sequence:
MPISATMVGALLGLGTQMYSNALRKLPYMRHPWEHVVGMGLGAVFANQLVKWDVKLKEDLDVMLAKARAANERRYFDEDRD
Protein: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (F6RXM1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XAQSEIRAVQLSYLYLGAMKSLSALLGCSKYAELLLIPKVLAENGHNSDCASSPVVHEDVEMRAALQFLMRHMVKRAVMRSPIKRALGLADLERAQAMIYKLVVHGLLEDQFGGKIKQEIDQQAEESDQAQQAQTPVTTSPSASSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTTVLPTRRAQTPPISSLPASPSDEVGRRQSLTSPDSQSTRPANRTALSDPSSRLSTSPPPPAIAVPLLEMGFSLRQIAKAMEATGARGEADAQSITVLAMWMIEHPGHEDEEEPQPSSTADSRHGATVLGSGGKSNDPCYLQSPGDIPSADAAEMEEGFSESPDNLDHTENAASGSGPPTRGRSTVTRRHKFDLAARTLLARAAGLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDNDILGMWIPEHVCESEDREEVVVCELCECNVVSFNQHMKRNHPGCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGSCREKYLALKTKTKTTNSERYKGQAPDLIGKQDSVY
Protein: Long chain acyl-CoA synthetase 1 (EC 6.2.1.3) (Protein ECERIFERUM 8) (O22898)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Acts in both the wax and cutin pathways. Preferentially uses palmitate, palmitoleate, linoleate and eicosenoate. Seems to have a specific activity against very long-chain fatty acid (VLCFA) class with acids longer than 24 carbons (C(24)).
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:20237894}.
Interaction partners:
- Palmitoyl-acyl carrier protein thioesterase, chloroplastic
- Oleoyl-acyl carrier protein thioesterase 1, chloroplastic
- Oleoyl-acyl carrier protein thioesterase 2, chloroplastic
- Peroxisomal acyl-coenzyme A oxidase 1
- Putative peroxisomal acyl-coenzyme A oxidase 1.2
- Diacylglycerol O-acyltransferase 3
- Probable acyl-CoA dehydrogenase IBR3
- Acyl-coenzyme A oxidase 3, peroxisomal
- Acyl-coenzyme A oxidase 2, peroxisomal
- Acyl-coenzyme A oxidase 4, peroxisomal
Sequence:
MKSFAAKVEEGVKGIDGKPSVGPVYRNLLSEKGFPPIDSEITTAWDIFSKSVEKFPDNNMLGWRRIVDEKVGPYMWKTYKEVYEEVLQIGSALRAAGAEPGSRVGIYGVNCPQWIIAMEACAAHTLICVPLYDTLGSGAVDYIVEHAEIDFVFVQDTKIKGLLEPDCKCAKRLKAIVSFTNVSDELSHKASEIGVKTYSWIDFLHMGREKPEDTNPPKAFNICTIMYTSGTSGDPKGVVLTHQAVATFVVGMDLYMDQFEDKMTHDDVYLSFLPLAHILDRMNEEYFFRKGASVGYYHGNLNVLRDDIQELKPTYLAGVPRVFERIHEGIQKALQELNPRRRFIFNALYKHKLAWLNRGYSHSKASPMADFIAFRKIRDKLGGRIRLLVSGGAPLSPEIEEFLRVTCCCFVVQGYGLTETLGGTALGFPDEMCMLGTVGIPAVYNEIRLEEVSEMGYDPLGENPAGEICIRGQCMFSGYYKNPELTEEVMKDGWFHTGDIGEILPNGVLKIIDRKKNLIKLSQGEYVALEHLENIFGQNSVVQDIWVYGDSFKSMLVAVVVPNPETVNRWAKDLGFTKPFEELCSFPELKEHIISELKSTAEKNKLRKFEYIKAVTVETKPFDVERDLVTATLKNRRNNLLKYYQVQIDEMYRKLASKKI
Protein: Protein kinase kin1 (EC 2.7.11.1) (P22987)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in establishing the characteristic rod cell shape. Important for cell polarity and is involved in directing growth to the cell ends.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14596912}. Note=Localized to the cell tips except during mitosis.
Interaction partners:
- 5'-AMP-activated protein kinase subunit beta
- 5'-AMP-activated protein kinase subunit gamma
- Autophagy-related protein 17
Sequence:
MEYRTNNVPVGNETKSAALNALPKIKISDSPNRHHNLVDAFMQSPSYSTQPKSAVEPLGLSFSPGYISPSSQSPHHGPVRSPSSRKPLPASPSRTRDHSLRVPVSGHSYSADEKPRERRKVIGNYVLGKTIGAGSMGKVKVAHHLKTGEQFAIKIVTRLHPDITKAKAAASAEATKAAQSEKNKEIRTVREAALSTLLRHPYICEARDVYITNSHYYMVFEFVDGGQMLDYIISHGKLKEKQARKFVRQIGSALSYLHQNSVVHRDLKIENILISKTGDIKIIDFGLSNLYRRQSRLRTFCGSLYFAAPELLNAQPYIGPEVDVWSFGIVLYVLVCGKVPFDDQNMSALHAKIKKGTVEYPSYLSSDCKGLLSRMLVTDPLKRATLEEVLNHPWMIRNYEGPPASFAPERSPITLPLDPEIIREMNGFDFGPPEKIVRELTKVISSEAYQSLAKTGFYSGPNSADKKKSFFEFRIRHAAHDIENPILPSLSMNTDIYDAFHPLISIYYLVSERRVYEKGGNWNRIAKTPVSSVPSSPVQPTSYNRTLPPMPEVVAYKGDEESPRVSRNTSLARRKPLPDTESHSPSPSATSSIKKNPSSIFRRFSSRRKQNKSSTSTLQISAPLETSQSPPTPRTKPSHKPPVSYKNKLVTQSAIGRSTSVREGRYAGISSQMDSLNMDSTGPSASNMANAPPSVRNNRVLNPRGASLGHGRMSTSTTNRQKQILNETMGNPVDKNSTSPSKSTDKLDPIKPVFLKGLFSVSTTSTKSTESIQRDLIRVMGMLDIEYKEIKGGYACLYKPQGIRTPTKSTSVHTRRKPSYGSNSTTDSYGSVPDTVPLDDNGESPASNLAFEIYIVKVPILSLRGVSFHRISGNSWQYKTLASRILNELKL
Protein: Pipsqueak, isoform M (A1Z8A6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00320}.
Interaction partners:
- Polycomb group protein Pc
- Polycomb protein PHO
- Histone-lysine N-methyltransferase E
- Polycomb protein esc
- Polycomb protein Su
- Polycomb group protein Psc
- Chromatin assembly factor 1 p55 subunit
- Polycomb protein esc
- E3 ubiquitin-protein ligase RING1
- Histone deacetylase HDAC1
Sequence:
MAAVRGHQYFSLRWNNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHPTIILPADIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAEQLKIKGLCETAENADDLNDAATATITVSENIQQAVVGNIVNAAIVPGAPSPSLEQQQQHHQQQQQQQAQEQHQQQQVHAQQQQQQQQQINAALLTQHGVSSGSVSLSGQLLSSSASGSSGSLAGGQQASQTPSGLQPTPRKSRLKRSKSPDLSSGGGAGSSGGSSSGSTQQQPQPAHHHHPQTILIQGQNPNSIVSLQQTADGNYIPVSGSGDDSDAEDHEHEHNHGHGHGHGGHTHGHGHSHEHSHDHEHEHKPNKICKTEHSVASPASNSSSASNNAAGVSGVTSTGQAIVTQIVVARDGKDTKNMTSLGMGMNGGLLGVPMGFLDFTPEPPAPSATPVTVTEHVDLSCNPSTDTRDLSNTTEPLDIDNHLAQQIHRLDQSPMHSISHHHTGDESNSNLVQHIKSEVIEAKHLAAQHHALSQAQQQHAHHQAHQQHQQHQQQQHQQQQQHLHAQQLLAQSQLQQQQQQQQQQQQHHQQQQQQAAAAAAAAGVHGQHGGHVTHADIGGATVMEIDPSQIKHEPGMIITPEIVNMMSSGHMDMYNSDTSEDSMMIANGSPHDQKEPHYTNLDQQHGLGGSVCGPGPGGAGGGGGMSGGAGSGSGEKALDALKNQNMSLTKASAIYGIPSTTLWQRAHRMGIETPKKEGGTKSWNEDALQNALEALRSGQISANKASKAFGIPSSTLYKIARREGIRLAAPFNAAPTTWTPEDLERALEAIRAGNTSVQKASAEFGIPTGTLYGRCKREGIELSRSNPTPWSEDAMNEALNSVRVGQMSINQAAIHYNLPYSSLYGRFKRGKYDVVANTSGVALLNTSGNTTGSIEIIEHSQENSQQFPYSPSPHPPTPQHHSTPQHHSSAQQGPPTPQHMQQHVVHMQQQQQQQQQQSPHPGHHPQHMQQDVVTSSSQVVHSQQQQQLQQIYQHHGTPERSXESLHAATLMGSTGGGGGGGVGGVAASTSDGTAASSTPFASISALVSGPSSAPPPPVTASGSSAVSGGTSKRKKANKQKR
Protein: Mx3 protein (Q98992)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MNNTLNQHYEEKVRPCIDLIDSLRSLGVEKDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLELKMKRKKEGEEWHGKISYQDHEEEIEDPSDVEKKIREAQDEMAGVGVGISDDLISLEIGSPDVPDLTLIDLPGIARVAVKGQPENIGEQIKRLIRKFIMKQETINLVVVPCNVDIATTEALKMAQEVDPEGERTLGILTKPDLVDKGTEETVVDIVHNEVIHLTKGYMIVKCRGQKEIMERVSLTEATEREKAFFKEHAHLSTLYDEGHATIPKLAEKLTIELVHHIEKSLPRLEEQIEAKLAETHAELERYGTGPPEDSAERMYFLIDKVTAFTHDAINLSTGEELKNGVRLNVFSTLRKEFGKWKLHLEHSGENFNQRIEGEVADYEKTYRGRELPGFINYKTFEVMVKDQIKQLEEPAVKKLKEISDAVRKVFLLLAQSSFIGFPNLLKSAKTKIEAIKQVNESTAESMLRTQFKMELIVYTQDSTYSHSLSERKREEEEDEDKPFSEIRSTIFCTDNHATLQEMMLHLKSYYSIASQRLADQIPMVIRYLVLQEFASQLQREMLQTLQEKDNIEQLLKEDFDIGSKRASLQSKLKRLMKARSYLVEF
Protein: CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Menage a trois) (RING finger protein MAT1) (Q7KPG8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR003338}.
Interaction partners:
- Cyclin-dependent kinase 7
- Cyclin-H
- General transcription factor IIH subunit 4
- General transcription factor IIH subunit
- General transcription factor IIH subunit 1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription factor IIH subunit 3
- Transcription initiation factor IIE subunit beta
- General transcription factor IIE subunit 1
Sequence:
MDDQACPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFLKGSGACPECMVPLRRNNFRVQLFEDPMVEKEVDIRRRILRDYNKREEDFASLAEYNDYLEEIEDIVYNLCNNIDIIETNKRIEAYKRDNREVIQRNKTRVGRDEYALEEMLELEKVQEEARRKELEELENEHKKKKARDKQALIEELMYSGKDAAQIVTEFAEKAEKQREEEKQLPPPKPANEFSTGIKFGQTADPSLLPVPKSEEGPLFVYEPLVPFSEGPAMPPTNEIVSRGYIAHIRAETPQENAGGFTSALACERALQEALQGLYYTATTGVVSGT
Protein: T-cell surface glycoprotein CD1e, membrane-associated (hCD1e) (R2G1) (CD antigen CD1e) [Cleaved into: T-cell surface glycoprotein CD1e, soluble (sCD1e)] (P15812)
Organism: Homo sapiens (Human)
Function: T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
Subcellular location: [T-cell surface glycoprotein CD1e, membrane-associated]: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.; SUBCELLULAR LOCATION: [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen.
Interaction partners:
- T-cell surface glycoprotein CD1b
- C-type lectin domain family 4 member K
- CD83 antigen
- Macrosialin
- Beta-2-microglobulin
- T-lymphocyte activation antigen CD86
- T-cell surface glycoprotein CD4
- T-lymphocyte activation antigen CD80
- T-cell surface glycoprotein CD1a
- T-cell surface glycoprotein CD5
Sequence:
MLLLFLLFEGLCCPGENTAAPQALQSYHLAAEEQLSFRMLQTSSFANHSWAHSEGSGWLGDLQTHGWDTVLGTIRFLKPWSHGNFSKQELKNLQSLFQLYFHSFIQIVQASAGQFQLEYPFEIQILAGCRMNAPQIFLNMAYQGSDFLSFQGISWEPSPGAGIRAQNICKVLNRYLDIKEILQSLLGHTCPRFLAGLMEAGESELKRKVKPEAWLSCGPSPGPGRLQLVCHVSGFYPKPVWVMWMRGEQEQRGTQRGDVLPNADETWYLRATLDVAAGEAAGLSCRVKHSSLGGHDLIIHWGGYSIFLILICLTVIVTLVILVVVDSRLKKQSSNKNILSPHTPSPVFLMGANTQDTKNSRHQFCLAQVSWIKNRVLKKWKTRLNQLW
Protein: Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) (O45624)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MQCSPDPEDLLIVPTHDIPSYDESLDPFGPEGHLSLDIDCFSKFMSRSDNRIMSKPIIVRGIPWRILAICRNQQGSRHSMNSRVNRSNFNFGFFLQCNNDELLQKRGMWRCYGTAVLEVLNADGPSIQKKIHHSFHNTEVDWGFSNYDQYDTLCNPKDGYVVNDTIKLRCRFTADVPTGANYMWDSKRHTGCIGLRNQGATCYMNSILQSFYFTTGFRRAVYNMDVGTEPNESNIVLAMQRVFYELQMASEAVETNSLTRAFGWDKLDAFNQHDVQEFCRVLLDNLETKMKGTSEEKSIPNLFRGNMKSYIKCLDVDYESSRTESFYDVQLNVLGMDSLERAFEAYTTSEILDDENKYDAGDHGLQRAEKGVKFVELPPILHVQLMRFQYCGVEQKINERFSFPEKMNLASCCELGPMLTEEDCVYSLHAVLVHSGEFHGGHYVTYINVNLHESAVDPTSSAKWCKFDDDVVSRTTTDDAIVSNFGGEKTMNSSAYMLVYVRDNAIDQFLAPIPDSQIPQSVSRTFEMERLHRNREKKKLEEEQLCMGIVLVTPDIVASNHSFDLVDQSIVHDSIPHETVWKHMFTAELYQFVHDRLFEKSAMQKIDMFDSDDEARQARRDNLRRIKSKKFNFRLWRMTDSYSLERTTQKLTSRLRPSEFIDCKTDTRLDTLLSQDFETIYVEFSNNIERPLCEYDTARDLLFFVKYYDTMTDKFTIIGHTMFDCHKRFNLYRSMLCEMIGLPADTELKYYMEHAASYLELVDLTQNYSIGRLVEEQDGGILVVEKVETSTSTQNAKQKMNELFLDVEVEFVQSFYNKKPEEEPFEQFVKRICLDDKLFTVAEEIGARLNVDPKKVLIWTRVSGSRFEPFFDDYMLNTCKGLMTRPVHDPRAYKRYRVQYAIMPFDIDEISKHRIQTKLFWQLPNGHVEELTLFPLKEGTVIDIINEAKRYYPFVEGGSGKFRLLQIGAPPLSNQRVYQIYGENTLISDLDQRTMYKLQALHCRLEEVPIDELDMSPGEFLCPVVHFDREPTKLFGLSFVIKIRNNELMTEVRDRLRRKLNDVSDADFAKYKFALLSRDKLCRTIEFNNGEKVNLADMANQTTGVPQVYIGLDHKSPIQHSSEAAIRILN
Protein: Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) (Q60520)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation.
Subcellular location: Nucleus {ECO:0000269|PubMed:21454521}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q96ST3}. Note=Recruited to the nucleolus by SAP30L. {ECO:0000250|UniProtKB:Q96ST3, ECO:0000269|PubMed:21454521}.
Interaction partners:
- Histone deacetylase complex subunit SAP18
- Sin3 histone deacetylase corepressor complex component SDS3
- Nuclear receptor corepressor 2
- Nuclear receptor corepressor 1
- Methyl-CpG-binding protein 2
- Histone deacetylase 1
- Histone-binding protein RBBP4
- Histone deacetylase complex subunit SAP30
- Histone deacetylase 2
- Histone-binding protein RBBP7
Sequence:
MKRRLDDQESPVYAAQQRRIPGSTEAFSHQHRVLAPAPPVYEAVSETMQSATGIQYSVAPNYQVSAVPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSSQSAPTPAQPAPQPTAAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHSGTGATPPVKKKPKLMSLKESSMADASKHGVGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLESFPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAPKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEVCVQVTDLYLAENNNGATGGQLNSQTSRSLLESAYQRKAEQLMSDENCFKLMFIQSQGQVQLTVELLDTEEENSDDPVEAERWSDYVERYMSSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVESLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSINKYRVKYGTVFKAP
Protein: Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Q9WUR2)
Organism: Mus musculus (Mouse)
Function: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).
Subcellular location: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:24344334}.; SUBCELLULAR LOCATION: [Isoform 2]: Peroxisome matrix {ECO:0000269|PubMed:24344334}.
Interaction partners:
- Trifunctional enzyme subunit beta, mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 1
- 3-ketoacyl-CoA thiolase A, peroxisomal
- Enoyl-CoA delta isomerase 3, peroxisomal
- 3-ketoacyl-CoA thiolase B, peroxisomal
- Enoyl-CoA delta isomerase 1, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 2
Sequence:
MAAVTWSRARCWCPSVLQVFRLQVAKLHLGRPTMRASQQDFENALNQVKLLKKDPGNEVKLRLYALYKQATEGPCNMPKPGMLDFVNKAKWDAWNALGSLPKETARQNYVDLVSSLSSSSEAPSQGKRGADEKARESKDILVTSEDGITKITFNRPTKKNAISFQMYRDIILALKNASTDNTVMAVFTGTGDYYCSGNDLTNFTSATGGIEEAASNGAVLLRDFVNSFIDFPKPLVAVVNGPAVGISVTLLGLFDAVFASDRATFHTPFSQLGQSPEACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYAKLPPNAMRISKELIRKNEKEKLYAVNAEECTTLQARWLSEECMNAIMSFVSRKPKL