wanglab/gogpt-training-data huggingface dataset:
Protein: LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) (KIZ-1) (P53668)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16204183}. Nucleus {ECO:0000250|UniProtKB:P53667}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P53667}. Cell projection, lamellipodium {ECO:0000269|PubMed:25107909}. Note=Predominantly found in the cytoplasm (By similarity). Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner. {ECO:0000269|PubMed:25107909}.
Interaction partners:
- Cofilin-1
- Cofilin-2
- Bone morphogenetic protein receptor type-2
- Serine/threonine-protein kinase PAK 1
- Rho-associated protein kinase 1
- Rho-associated protein kinase 2
- Serine/threonine-protein kinase PAK 4
- LIM domain kinase 2
- Serine/threonine-protein kinase PAK 2
- Serine/threonine-protein kinase PAK 3
Sequence:
MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCECSVSLSHQYYEKDGQLFCKKDYWARYGESCHGCSEHITKGLVMVAGELKYHPECFICLACGNFIGDGDTYTLVEHSKLYCGQCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASAHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDSLGHGPVSDPSPLSSPVHTPSGQAASSARQKPVLRSCSIDTSPGTSSLASPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETLRMHLSGHLPLGPQLEQLERGFWETYRRGESSLPAHPEVPD
Protein: Putative uncharacterized protein encoded by LINC02913 (Q8NAJ2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAYVALSDKPHLSGEVGEEACSSWNPPLFSPRPLPRLWPLPGTPFLPIRALPFSASSSGKSSLVPSPSSSAHSGFRTPCLGPDCLLCTQGCELHEGRNHMAVHSCVARAWPGDPQEVRHLNPLLCDPGSQVEPSWPWHPGLEQAAASWVGNHVSPAHRQALRGHSLGSALRALMPGGHCPLCVPCKRGCNLRGGRGKHGPRPCCPLLRKFPVLPVHPWPFPCAVWDSGWSCR
Protein: Spinophilin, isoform S (Q9W003)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MEKPMHHAPAPVGKVSQIANIFQRKPIEIQPVEQLSAVAAAHAAAAAAAAAAHHAHVQGAPAVRTESHSARFNNARALFEKLGVESNSNVSSRLLRSGSREDNLCDGSDRSSSRSSDRSQSPPKRRTPFPSGVSLVHNNNNAAIVAQNGVPPEQRLSNSKFIVEPAAQVVPTSVVKYPQHNISRLKSEEPSPVPPPASGSVSALFASSGGDKPEKPERKFNSRELIEKQKKWTSHFTKTKTTRTHSDLNRCDIIRTVPGTGLIMDSEKVAKPAMEPPQPPPNASPNPPMRAQAPPEIKPRSGKIGSPVKSPPLPPIPAVKPKNVSPVKFNPDRLRQSPTKTADNSPPPPPAKSAAVLQRSLMQEQQELLRNSCDQGVAPIPPEKPRKKSVDLIEDTLPLTNCSTPSSCASPTSSYLMQPAKRGSLDGGSGNGQYPGNGLSGSTNSATSGSPVASASSGPSSPVHTEDEKQENESTEKSEMEYYHGGNYNSVPRRRRSENEGRKSVDESSPSANNSQQQQQHSIPGSAAGSPQRVANKRSSITVNMPAAGLGQRPPSIISTTSQDEGGFNESAPELKAKLQPAYDQTEEQPHSLNYVDVGYRLNPDGSESREVYGSEAELYDTAKVTDMQRKFHGANGFGQESSTVYAIIKPDVQESQPVAPSRSVLIQSPNSSSVEGSPLHRGSYSSPPVGVVSPIRRRNSSNQDQSVGGGGSAKTTPQCSPARSALVKGIAPIASIDAHEEEELDLVEEDEHLAVEYVEVLELQQDEEEEEAPVLPERRAPAQGSLELQDLEYADTSAGEDEEDIINHLKDGDVLDVELIDDVVDEVIKVHVNHSVATAPSIQAATPAAAIPREDSLPDDMTAAEAERLLSSSILENKIRQQSLLSDEQAKEVEQILNAAPSVGVAVATVVATATSPTSIKNLIEDLPGQSAVAASAANGEQDIQIAAVPAIVEEDEDEEEDFPEDDEEDHARADFDANGGDADGDSDDVEAVDIVGYGHASTALNATFVKADSTETETTTTTPSTATTATTRHDDDEPEWLRDVLEAPKRSLENLLITSATSSRAPGQREELENGYDLHEKHSDLNQTYITGGESLHESIVSVESTQSDATLNQTTTIDDSIISSKHNSTYSLADAEQATSSTVLSTGVTELDDSQYYIPEYPPVRSKEVLVEAGVHYFEDGNFWMEVPGLLDFDDDDCSYPPITVRKNPKVRFSSGPIHVYSTFSVNDYDRRNEDVDPVAASAEYELEKRVEKMHVFPVELMKGPEGLGLSIIGMGVGADAGLEKLGIFVKTITDNGAAARDGRIQVNDQIIEVDGKSLVGVTQAYAASVLRNTSGLVKFQIGRERDPENSEVAQLIRLSLQADREKEERLKRQQEEYLRRTLDYSEDSTQPVSANSSVCEGPSSPVQVEHPMEVEATHSQEVESLKRLLQEHKALVKLETTGNENELLSERLRQSERELGNIRKEAANLQNMLQQSQGQYMALDKKYNKAKRLVREYQQRELDMCHREEFYQQLLQEKDTEYNALVKKLKDRVINLEHELQETQRKAGFPVGLPYDSATLKLTPQMMRKTPPKPLFHKLETELSDTEISDLSPDGDGVKTATVERKVPVKDELDAAVPQHELLDNSINKTKIDLASRGGLANRQLPSANGNSSTSNGAAVDLGQLSNGNLLKRSRSNSRSSDCTLDDTDEEEEREGSALNLAGAPVAHETISLSNGNSHLLANVNNLLQHHPPAMATVIATPSNGHLGTTTPILLNSTSSASSSSSNQSTAREAQINQLYAQVHKDPSKQQHQQQQQQQQQAQAVTTSIPSIFKNALGSPADNGLNDFHRGSMTTFGTGPATSSNRDLNSSYDSILGSNDKLAENDPAESWMYPSRRRVAPNGSKVPLPGSSFTDQLNQALSDRERRLGDGSSRHSSDDYTEINKSQSAAAINCKTLINEIRQAVNEAQPKVPWQQQHHQQIQQQPSAHTTGPPSPTSMSSGCSSPGYSPSRTLDLSGSSSSFSDRKAMAAGYTYKGGPVHEWTKDQVGHWLMGIELERYIPVFKENNVEGGALLTLDSKDFKTLGICGDDKHRLKKRLKDLKANIEKERKDMERERREREKAIRKAEKKAAKKK
Protein: phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (A0A8I6AFY1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
Sequence:
MRKTRLKPSPDKNHPLYLSSSFQGSQGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRAADALIAISNYRLHIKFKDSVINVPLRMIDSVESRDMFQLHIACKDSKVVRCHFSTFKQCQEWLSRLSRATARPAKPEDLFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRASGGSLSAGTNDASEACDTDFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENAEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPGSDMVLHPVCHVRALHLWTAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNLNNHCQEVRVSLEPWHSNPEGAEAVIESGVGSPQLTVGDVGLPPPLPSSQKDYLSNKPFKGHKSCSLSYKLLNTSVSWEMKNTSEIKVLEETEALAPGPPAREEQSRTSDGLGKPPEQCPEKEATSSLSNVSSKCGGACDFPGEPPQDSFTGTPQQPHLDSMQAVPIRCTPDHGQGSLCNPPSAASQTLQEPNTDLISQDPPGSMAGISYQEQPSSVSDLIYKKEDAGKRGSKNGQLVENPRFGKMPLELARKPISQSQISEFSFLGSNWDSFQGMMTSFPSGETTPRRLLAYGCCSKRPSNKHIRAAAPCFGGQWAQREGMKSPVCSSHSNGHCTGPGGKNNRMWFSSHPKQVSSTKPSLLSCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYKQEVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCLSEASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQHLKKPIATASS
Protein: Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (D4A7K4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR038189}.
Interaction partners:
- TNF receptor-associated factor 6
- Myeloid differentiation primary response protein MyD88
- Interleukin-1 receptor-associated kinase-like 2
- Interleukin-1 receptor-associated kinase 1
- NF-kappa-B essential modulator
- Toll-like receptor 4
- Interferon regulatory factor 7.
- Toll/interleukin-1 receptor domain-containing adapter protein
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Sequence:
MSKPLTPSTYVRSLNVGILRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTCELLFDWGTTNCTVGDLVDLLIQIELFAPATLLLPDAVPQAVHSLPPREAATVAQAHRPCQEKNRTTVTPALAQKLEPSCELPDSSSPGHQSVEFSDTRFHSFSFYELKSITNDFDERPVSIGGNRMGEGGFGVVYKGCVNNTTVAVKKLGAMVEISTEELKQQFDQEIKVMAKCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPLSWHMRCKIARGAANGIRFLHENHHIHRDIKSANILLDQDFTAKISDFGLARASAKLAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLELITGLAAVDENREPQLLLDIKEEIEDKEKTIEDCTDEKMSDADPASVEAMYSVASQCLHEKKNRRPDIAKDPLV
Protein: Large ribosomal subunit protein uL16y (60S ribosomal protein L10-2) (Wilms tumor suppressor protein homolog) (Q08770)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein eL21x/eL21w
- Large ribosomal subunit protein uL15y
- Large ribosomal subunit protein eL24y
- Large ribosomal subunit protein uL5y/uL5x/uL5w
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL4y
- Small ribosomal subunit protein eS6y
Sequence:
MGRRPARCYRQIKGKPYPKSRYCRGVPDPKIRIYDVGMKRKGVDEFPYCVHLVSWEKENVSSEALEAARIACNKYMVKSAGKDAFHLRIRVHPFHVLRINKMLSCAGADRLQTGMRGAFGKALGTCARVAIGQVLLSVRCKDAHGHHAQEALRRAKFKFPGRQKIIVSRKWGFTKFNRADYTKLRQEKRIVPDGVNAKFLSCHGPLANRQPGSAFLSAGAQ
Protein: Synaptosomal-associated protein (H3BP15)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
Interaction partners:
Sequence:
XQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKQADRSGNH
Protein: Guanine nucleotide-binding protein-like 3 homolog (Nucleostemin-1) (Q21086)
Organism: Caenorhabditis elegans
Function: May play a role in regulating cellular proliferation in both germline and somatic tissues.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- RRM domain-containing protein
- Pescadillo homolog
- Nucleolar GTP-binding protein 2
- Nucleolar GTP-binding protein 1
- Nucleolar complex protein 2 homolog
- Ribosome biogenesis protein BOP1 homolog
- Probable rRNA-processing protein EBP2 homolog
- ATP-dependent RNA helicase
- NLE domain-containing protein
- 26S rRNA
Sequence:
MAKYCLKKTSKRVSCAKRYKIEKKVRDHNRKVKKEAKKNGTTNKKEKTISVPNSCPFKEEILVQAEQEREKIKVRQEAAKEAAKIHRIEKRKNNLPANFESMVAKASKQGTEFDKKVASAAEHEKFNTLDDKTIKAYASEVRKTVEIADVIIQVLDARDPLGSRSKSVEDQVLKGGKRLVLLLNKIDLVPRENVQKWLEYLRGQFPTIAFKASTQEQKSNIGRFNSAILNNTETSKCVGADIVMKILANYCRNKDIKTSIRVGVVGFPNVGKSSVINSLKRRKACNVGNLPGITKEIQEVELDKNIRLIDSPGVILVSQKDLDPIEVALKNAIRVDNLLDPIAPVHAILRRCSKETIMLHYNLADFNSVDQFLAQLARRIGKLRRGARPDVNAAAKRVLNDWNTGKLRYYTHPPEQGTAKEDIVVPAEVVSQFSKEFDIDAIAEEQNQIVEGLPMESDIIAPHNSDEEEDDDDEMETDVNEKKQTVTSGRKVKGPTKDDDKPVLPESLALEGNVQLNKLIKTAIKKQKKKSKKTANRADKLSDSLGNMLGGDAMEM
Protein: Ras-related protein RABA1d (AtRABA1d) (Ras-related protein Rab11B) (AtRab11B) (Ras-related protein SGBP) (AthSGBP) (Q9SN35)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intracellular vesicle trafficking and protein transport.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:20841426}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:20841426}; Lipid-anchor {ECO:0000305|PubMed:20841426}.
Interaction partners:
- Vesicle transport v-SNARE 12
- ADP-ribosylation factor
- Kinesin-like protein KIN-14E
- Phosphatidylinositol 4-kinase beta 1
- V-type proton ATPase subunit a1
- ADP-ribosylation factor
Sequence:
MAGYRADDDYDYLFKVVLIGDSGVGKSNLLSRFTRNEFSLESKSTIGVEFATRSLNVNEKVIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDVTRHSTFENVERWLRELRDHTDPNIVVMLVGNKSDLRHLVAVQTEDAKSFAENESLYFMETSALESTNVENAFSEVLTQIYHVVSKKAMEAGEDSGNVPSKGEKIDVDVSAVKKTGCCSN
Protein: Putative mismatch repair protein MSH2 (Q9BLY3)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MSDDRDPAVVQAFNGAGGDDTSCLRLFSRASAGCFILGSWASLVAREYVKSTAVLKNWSGVDAVAVNDSITREVIRDCLLRRGVSVEQYDRQTSGGRYVCMRRGSPGHIADFEAMLFAFEDAEIQLMAIGSVVIDDKANRVNGPGGQHVRVGYAALNTTLRTLTYAEYHDTPQLTNLDVLMAQCNLKQLLYSNTDFSMNNTGEKAADSDESREQSDLLRALKQLCERANITLQERGQSNLPHGKQKSRATKRNSTGPNGELLSTLEGILRVPEDRHGLNSFPLASRALESLLESAIDPFDSTNQHTFYLKHVIPSTFMKMDAAAIEALHIIHRKPEARGSMPTSIYSWLNRCTTGMGSRLMQQWLLQPLRSIEDINQRLSLVQIMVESPILRDALITQVLRRCTDMDRLNRKLQRRTVALKDLQSILVFANTVPLAVDVLRTYHGGHDSSLLLKGYVTPLEDISEHLSNLRTLINATVDLSDENTVRINPEFDDDLSFLERQRQNLVKAIEKENHRVLKQCGWTEKQMKCEYHASYGYVFRVPRKDDHQVRTSKEFITVSTAKDGVRFVSGQLSSLSEQYKGITEDYKTRQQVLKKKLVDTVATYLPVLDDAKELLAALDVFAAWALVVKDSSRPMVRPTVRATQSEEVKGNVDNNSDGAILTIVNARHPLVELRQPAFTPNTVQLTNEANALIITGPNMGGKSTFMRSIGVCVALAQAGCFVPADSADIVVRDAIMCRVGATDHLAQGVSTFMVEMLESAAMLNSATQQTLAIVDELGRGTSTYDGFGLAWAIAQEVAVNAKSALLFSTHFHEMTQLAARHTNVRNVHFGADVDTAARTLRFSYQLQPGPCGRSYGLYVAQLAHIPDDVLDFARQKAVELEDFGGDETKNRAQVLFSTATPEVVQRVTEYAKRIRELESGEGDGDSREAARRRLCSEIKEDALLSSLVEV
Protein: Transcriptional regulator of the unfolded protein response hacA (BZIP transcription factor hacA) (Q4WEY8)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Master transcriptional regulator of the unfolded protein response (UPR) that recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes. In the canonical UPR pathway, the ireA RNase splices the cytoplasmic mRNA hacA, which alters the reading frame to allow translation of the bZIP transcription factor hacA. Induces the expression of pmrA, scrA and spfA in response to UPR.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- Serine/threonine-protein kinase/endoribonuclease ireA
Sequence:
MEDNFASVVESLSGTSASALPLLTVSPADTSLKAPETKVQETKTEEKKPPKKRKSWGQELPIPKTNLPPRKRAKTEDEKEQRRIERVLRNRAAAQTSRERKRLEMEKLENEKIQMEQQNQFLLQRLSQMEAENNRLSQQLAQLTAEVRNSRNSTPKPGSPATASPTLTPTLFKQEGDELPLERIPFPTPSITDYSPTLKPSSLAESSDVTQHPAVSVGGLEGPGSALPLFDLGSGVEHDAANDIAAPLSDDDFHRLFNGDSSTEPDSSVIEDGFSFDILDSGDLSAFPFDSMVNFDSEPVALEGIEPAHGLPNETPYQTSGLQPSLGASTSRCDGQGIAAGC
Protein: Uncharacterized protein, isoform H (M9NEC3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNKVEFKNKNKDQGPCARVRKIRPINMGGNVEQRPWTPTVRIGKIAAETTNPGPATVQLPTLIGSKVPDSKKKAAPSYSFGHKLGGKYDTSGPGPAQYNVTGMRAKGRDYPRAATLQSRPKELTRFSNPGPGEYDVVPAAKAVIDATPKYTFGQRPVALKTFQIPGPNYYQVVPLDVVKRRAPRYSFRIKVNVYLVNNPAPGAYCPEKVKLNKTPEFSFGIKHHEQRPDYTPAPGTYKPEQVVLEHIPAYSFGLKTKHIQVSDTPAPGAYSPEKSRLHSAPAYSIAGKASQDVVDCTPAPGAYEPEKCVLSRTPAFSFGHRAELAKSSDTPAPGTYNPEKVRLDHTPAFTLSGRPETRSVSETPAPGSYAPEKYRNDRTPAFTFGGKHEQRLESSTPAPGDYCPEKVRHDHNPAFSFAGRHDLHKPSDTPAPGAYDTEKVRQDHNPAFSFAGRHDLHKPSETPAPGAYSPEKVRQDHNPAFSMAGKHSQKVTSDSPAPGDYCPEKVRLDHTPAYSFGVKSDPKVENNTPAPGDYHPEKVRQDHNPAYSFAGRHDLQKPDNTPAPGAYFPEKVRLDHNPAFSMAGKYDAKVTNDTPAPGDYSPEKVRQDTNPAYSFAGRHDLHKPSETPAPGAYSPEKVRLDHNPAFTMAGKHDQKILNGTPAPGDYSPEKCRLDHTPAYSFGGKNDPKVENNTPAPGDYHPEKVRLDHNPAYSFAGRHDLQKPSDTPAPGAYSPEKVRQDHNPAFSMAGKPVEKLTNGTPAPGDYSPEKVRLNHTPAYTFGGKNDPKVENNTPAPGDYHPEKVRQDHNPAFSFAGRHDLHKPNDTPAPGAYCPEKVRQDHNPAFSMAGKYTQKVANDTPAPGDYSPEKVRLDHTPAYTFGGKNDPKVESNTPAPGDYHPEKVRQDHNPAFSFAGRHNLQKPSDTPAPGAYSPEKVRQDHNPAFTMAGKHDPKVSNDTPAPGDYSPEKVRLDYTPSFTFAGKNNPKVENDTPAPGDYHPEKVRQDHNPAFSFAGRHDLHKPSDTPAPGAYSPEKVRQDHNPAFSMAGKYIEKITNGTPAPGDYCPEKVRLDHTPAFTFGGKNDPKVENNTPAPGDYHPEKVRQDHVPAFSFAGRHDLHKPNETPAPGAYSPEKVRQDHNPAFTMAGKHDPKVTHDTPAPGDYHPEKVRLDHNPAFSFAGRHDLHKPSETPAPGDYFPEKVRQDFNPAFTFAGKHDPRSLSESPAPGDYSPEKVRLDHAPAFSFGGKHDPKTEHLHPAPCDYAPEKVRLDHTPAYTIAGRPAADHVSQTPAPCDYHPEQCQVDSTPAFTFGMRLGRERISDTPAPSAYEPEKHSLHSTPAYSFGTKSDIRVTTDAPAPGHYHPEQCKLDSSPAYSFGLKTVPTASLPEPRGAYIEDRIVQRRERRLASPVRNNAECTTTTTNHTNNNAGSSTTTTTTTTTTTKTFINGVEQPELQKKETTKQVNGTHKELKSAPQAPLSNGNIVSNGNHSKMVSTTTRIQEVAHGQKESGNLKVVASGKSDASATKAAAVSHQTVVQADGAIVTSGQSSRMQTVKYAVEASSVQEKIISS
Protein: Aspartic proteinase A3 (EC 3.4.23.-) (Q9XEC4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the processing and degradation of storage proteins.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Expressed protein
- Aspartyl protease APCB1
- Eukaryotic aspartyl protease family protein
- Eukaryotic aspartyl protease family protein
- Eukaryotic aspartyl protease family protein
- Aspartic proteinase Asp1
- Eukaryotic aspartyl protease family protein
- Aspartic proteinase Asp1
- Aspartic proteinase NANA, chloroplast
- Eukaryotic aspartyl protease family protein
Sequence:
MGTRFQSFLLVFLLSCLILISTASCERNGDGTIRIGLKKRKLDRSNRLASQLFLKNRGSHWSPKHYFRLNDENADMVPLKNYLDAQYYGDITIGTPPQKFTVIFDTGSSNLWIPSTKCYLSVACYFHSKYKASQSSSYRKNGKPASIRYGTGAISGYFSNDDVKVGDIVVKEQEFIEATSEPGITFLLAKFDGILGLGFKEISVGNSTPVWYNMVEKGLVKEPIFSFWLNRNPKDPEGGEIVFGGVDPKHFKGEHTFVPVTHKGYWQFDMGDLQIAGKPTGYCAKGCSAIADSGTSLLTGPSTVITMINHAIGAQGIVSRECKAVVDQYGKTMLNSLLAQEDPKKVCSQIGVCAYDGTQSVSMGIQSVVDDGTSGLLNQAMCSACEMAAVWMESELTQNQTQERILAYAAELCDHIPTQNQQSAVDCGRVSSMPIVTFSIGGRSFDLTPQDYIFKIGEGVESQCTSGFTAMDIAPPRGPLWILGDIFMGPYHTVFDYGKGRVGFAKAA
Protein: Heterochromatin silencing protein rss1 (Q10214)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:38048463}.
Interaction partners:
Sequence:
MEETVNKILRAQETRAQLYKELEDALNANQEKKIGLEQMGIIVQLVTEGLNEVSSDIRNYQASLTKELKLLVDSLQEKERSKLQATVKLEQLKVVSTNSPVENTQISELEARLSSLSKEINDILQNMKDEI
Protein: Transmembrane protein 134 (Q9H6X4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27899274}.
Interaction partners:
Sequence:
MSAARPQFSIDDAFELSLEDGGPGPESSGVARFGPLHFERRARFEVADEDKQSRLRYQNLENDEDGAQASPEPDGGVGTRDSSRTSIRSSQWSFSTISSSTQRSYNTCCSWTQHPLIQKNRRVVLASFLLLLLGLVLILVGVGLEATPSPGVSSAIFFVPGFLLLVPGVYHVIFIYCAVKGHRGFQFFYLPYFEK
Protein: Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (Q98TT1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cytoplasm, Stress granule {ECO:0000256|ARBA:ARBA00004210}.
Interaction partners:
- FAU ubiquitin like and ribosomal protein S30 fusion b
- Eukaryotic translation initiation factor 3 subunit I
- Ubiquitin-like protein FUBI
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 2 subunit 2
- RRM domain-containing protein
- protein-synthesizing GTPase
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS5
Sequence:
MPNLSCRFYQHRFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEDAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFTRTAWVFDEKYKRPGYGAYDVFKQAVSDPAMLDGLDLTEEERAVLIDNINRRLTPQAVKIRADIEVACYGYEGIDAVKDALRAGLSCSTEAMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAAIKERIEEKRGVFNIQMEAKVVTDTDETELARQLERLERENAEVDGDDEDGEMEAKAED
Protein: Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (Solute carrier family 5 member 8) (Q8BYF6)
Organism: Mus musculus (Mouse)
Function: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:17099289, ECO:0000269|PubMed:17245649, ECO:0000269|PubMed:30604288}; Multi-pass membrane protein {ECO:0000255}. Note=Restricted to the apical cell membrane of enterocytes. {ECO:0000269|PubMed:17099289, ECO:0000269|PubMed:17245649}.
Interaction partners:
- Hydroxycarboxylic acid receptor 2
- Monocarboxylate transporter 1
Sequence:
MDASRDIGSFVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRCIRLCGTILFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFASVIIQASITQHGINKILSDAFNGGRLNFWNFDPNPLQRHTFWTIVIGGTFTWTTIYGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPWTSKKVSAIDQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSLSWISQGMSVLYGALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSIGALTGLLAGFAISLWVGIGAQLYPPLPERTLPLPLETYGCNITHNGSDWMSTTEMPFSTSAFQIHNAERTPLMDNWYSLSYLYFSTIGTLTTLFVGILISLSTGGRKQNLDPRFLLTKQDFLSNFDVFKKRNHVLNYKLHPVEVGGTDNPAFNHVELNFTDHSGKINGTRL
Protein: Uracil permease (P05316)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transport of uracil.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Tryptophan permease
- E3 ubiquitin-protein ligase RSP5
- General amino-acid permease GAP1
- pH-response regulator protein palA/RIM20
- Vacuolar-sorting protein SNF8
- Arginine permease CAN1
- Vacuolar protein-sorting-associated protein 36
- Protein SUR7
- High-affinity methionine permease
- Vacuolar protein-sorting-associated protein 25
Sequence:
MPDNLSLHLSGSSKRLNSRQLMESSNETFAPNNVDLEKEYKSSQSNITTEVYEASSFEEKVSSEKPQYSSFWKKIYYEYVVVDKSILGVSILDSFMYNQDLKPVEKERRVWSWYNYCYFWLAECFNINTWQIAATGLQLGLNWWQCWITIWIGYGFVGAFVVLASRVGSAYHLSFPISSRASFGIFFSLWPVINRVVMAIVWYSVQAYIAATPVSLMLKSIFGKDLQDKIPDHFGSPNATTYEFMCFFIFWAASLPFLLVPPHKIRHLFTVKAVLVPFASFGFLIWAIRRAHGRIALGSLTDVQPHGSAFSWAFLRSLMGCMANFSTMVINAPDFSRFSKNPNSALWSQLVCIPFLFSITCLIGILVTAAGYEIYGINYWSPLDVLEKFLQTTYNKGTRAGVFLISFVFAVAQLGTNISANSLSCGTDMSAIFPKFINIKRGSLFCAAMALCICPWNLMATSSKFTMALSAYAIFLSSIAGVVCSDYFVVRRGYIKLTHIYSHQKGSFYMYGNRFGINWRALAAYLCGVAPCLPGFIAEVGAPAIKVSDGAMKLYYLSYWVGYGLSFSSYTALCYFFPVPGCPVNNIIKDKGWFQRWANVDDFEEEWKDTIERDDLVDDNISVYEHEHEKTFI
Protein: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (P15938)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Influences the fidelity of branchpoint recognition in yeast splicing. This is RNA-dependent ATPase which is essential for viability. It may mediate one of the many ATP-requiring steps of spliceosome assembly and that accuracy of branchpoint recognition may be coupled to ATP binding and/or hydrolysis.
Subcellular location: Nucleus. Note=Binds to the spliceosome.
Interaction partners:
- Pre-mRNA-splicing factor SNU114
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-processing protein 45
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor CWC2
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-splicing factor CLF1
- Pre-mRNA-splicing factor ISY1
- Pre-mRNA-processing factor 19
- Splicing factor YJU2
Sequence:
MGHSGREERIKDIFKELTSKELTPGLLLTLQKLAQKPNTNLEQFIASCKALTKLSSNNPIIFNELLELLKNKSEEDSTGPKKIAPSINKRKKFKIQLDLDDNEDELDSPVQKKPAPTRTLFKRIDKLKAKQLRQYSPTVKDPSPNSEQQTQNGHAETKDYEPTRSEVVEEDREWYDNDDDYGNLVPEPLSELPEEAKLLPVIRNIDNDDALRNTVQLYPIPLKQRMEWIPPFLSKFALENKVPTSIIIGSISETSSQVSALSMVNPFRNPDSEFSANAKRGSKLVALRRINMEHIQQSRDNTTVLNTAMGEVLGLENNNKAKDKSNQKICDDTALFTPSKDDIKHTKEQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAISVAKRVAMEMQVPLGKEVGYSIRFEDVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMNAKKFSAFFGNAPQFTIPGRTFPVQTIYTSNPVQDYVEAAVSQAVKIHLANDCSSGDILIFMTGQEDIETTFDTLQEKFLQVYSKKFGTANFEEINDIEILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYNPKIGLDSLVITPISKANADQRSGRAGRTAPGTAYRLYTEDTFKEDMYLQTIPEIQRTNLSNTLLLLKSLDVTDELSKFPFIDKPPLQTFLSSLYELWFIGAIDTSGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSMLSVPQVFYRPKERQKEADIARNKFFIAKSDHLTLLNVFEQWRANNFSSHWCNKHFVQYKSLVRARDIRDQLLTILKSQKIPVISSGKDWDIIKKCICSGFAHQAAKITGLRNYVHLKTGVSVQLHPTSALHGLGDLPPYVVYHELLMTSKEYICCVTSVDPFWLMEYGGLLYDIKRIKNDQEATTTGLFGEHYEHTLDKVEDDIDINIRRCKDMRDSVIQELKMTDNSNKEDKKQKTKKQNILNGKENSMKPFKRRKPFF
Protein: ferric-chelate reductase (NADPH) (EC 1.16.1.9) (A0A1D8PQM2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MMKRGVSYNGLDCLADASSDAYMKYKHQSQAEIPWVSQTKYAKYTVYFGIATIFVAFVKQIYYKYRDYTYRSKQSSNFGTSLIDIWISYCRYYGYKQLPTWLTYFSIPGSVGSASYMFLSSLYMLCYCLVPHFWYRGCAGFGSSPLAVRAGLMATALTPFIYVLAGKSNAITLLTGISYEKLNTFHQYTGVACFILSVIHVVPFIYQDLAEGGSSNLKMNFKDSFEYYSGIPPLILLGLLCILSKSYIRKVVYELFLHAHWMMGIAYFGTLIWHINKELGADDYMWGALAFWATQIIYRILMKTAFKPNAMFLRSRQAQLEKLGSDGVYQVVIGNTTGVNWKPGQHCYLRFAGVRILDSHPFSIASVDEEDKTAMKFIIKAQKGLTRKIYQELDKSITSNKNVYVDGPYGGTFRDPRSFKRVVLLATGTGVTATLPFLTYLAKTDSIVKRVSFIWIVRSQEDIHWVKSELQECQKLGGSKIDIHIHVAAKKSIYTKGDFEKEIESEETNLNEEDWLIDYGKPSVTSILKSMAGSLAARNMIVCSGSDSLKREVSSIVSELQSLVFNNDLVRSNVEEIYLHTESFGW