wanglab/gogpt-training-data huggingface dataset:
Protein: Histone H2A.Z (H2A/z) (P0C0S6)
Organism: Mus musculus (Mouse)
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Essential for early development.
Subcellular location: Nucleus {ECO:0000269|PubMed:12660166}. Chromosome {ECO:0000269|PubMed:12660166, ECO:0000269|PubMed:15195148}. Note=Enriched in constitutive heterochromatin (PubMed:12660166, PubMed:15195148). Absent from facultative heterochromatin of the inactive X chromosome (PubMed:12660166). {ECO:0000269|PubMed:12660166, ECO:0000269|PubMed:15195148}.
Interaction partners:
- Histone H3.2
- Histone H3.3
- Vacuolar protein sorting-associated protein 72 homolog
- Histone H3.1
- RuvB-like 1
- Histone H3-like centromeric protein A
- Histone H4
- Acidic leucine-rich nuclear phosphoprotein 32 family member E
- E1A-binding protein p400
- Histone deacetylase 1
Sequence:
MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV
Protein: Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) (GABAAR subunit beta-1) (P50571)
Organism: Mus musculus (Mouse)
Function: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P08220}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08220}. Cell membrane {ECO:0000250|UniProtKB:P08220}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08220}.
Interaction partners:
- Gamma-aminobutyric acid receptor subunit alpha-1
- Gamma-aminobutyric acid receptor subunit beta-3
- Gamma-aminobutyric acid receptor subunit gamma-2
- Gamma-aminobutyric acid receptor subunit alpha-4
- Gamma-aminobutyric acid receptor subunit alpha-2
- Gamma-aminobutyric acid receptor subunit gamma-1
- Trafficking protein, kinesin binding 2
- Vesicle-fusing ATPase
- Huntingtin-associated protein 1
- Inactive phospholipase C-like protein 1
Sequence:
MWTVQNRESLGLLSFPVMVAMVCCAHSSNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNRLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTGVSDPKATMYSYDSASIQYRKPLSSREGFGRGLDRHGVPGKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
Protein: Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (FSH-B) (FSH-beta) (Follitropin beta chain) (P01227)
Organism: Ovis aries (Sheep)
Function: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01225}. Note=Efficient secretion requires dimerization with CGA. {ECO:0000250|UniProtKB:P01225}.
Interaction partners:
- Follicle-stimulating hormone receptor
- Glycoprotein hormones alpha chain
- Lutropin-choriogonadotropic hormone receptor
- Gonadotropin-releasing hormone receptor
- Thyrotropin receptor
- Progonadoliberin-1
- Uncharacterized protein
- Nuclear transport factor 2.
- Pro-opiomelanocortin
- Prolactin
Sequence:
MKSVQFCFLFCCWRAICCRSCELTNITITVEKEECSFCISINTTWCAGYCYTRDLVYKDPARPNIQKACTFKELVYETVKVPGCAHHADSLYTYPVATECHCGKCDRDSTDCTVRGLGPSYCSFSDIRE
Protein: Uncharacterized protein (Q382A0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSKEAPHRFLLETRSQQLHRLEAIRRRRELLERESQKPVQMRFGIGGRGPSWSPPPRIQSPVVTTVNGVQKRPAETRKGFSSCSRCPRSCEPRKATHVPLVRSRSAPHMRLSQCFATRSTSNRRTSLVPPFGSLCNLQQKKDTPPIKRMLKRQRSRTVSTSPSTSLTSRFRRRTPLASARNKEKMTPWNNFPNTSRSAQILTPPLGPKHGKRVSAPRERSPSPLPSSTQTTAINGTTHDEQRQPAVTLGSETVSSSPTNRFPLPRSRSVSNAEPKEMVNQHVGSSPLRCVSDENMETVTAFRVSEFPTPRTPKLRESLAVSLSPATSQGVSIKQELVAETRISTDSSPPVVKEEATCNPCDGLLLQSSTCQSVFVGSSSVLTGGLCEVDIHLNEESDAPPPCEIETSRDNKETRVSAAASPAGESDIVSMSPSSPGCKAAAACRPSAMTSYTFDCSPTTSEFDGTEIERNSHRQLMFDMEESQSSTVAVEDKKNADGQLHQHVSGEDEELENDSDLNNREEELCTPRDNRGEWLPDTLTHGLDASAESEKPHECVNALCTPVDQILYSSPLCEMVSPRPQTPLLQVRMEHKLTMLNTAEREDENSRGSLLLVTGESPIPHTPVLQEPHTPPPTEGVPLFISNTSNLPRPVTLISALQSPMSARRLVRPVAESPIGECAVWNGGKWSPPMRTDLNKEPTVQPREVVDLERRYLEAGSGLQGESVPSSSSSPCSGSRFKNKKLPTDLLMVSHILEASEEAHQPITSETSCCTPSHSQGNDQASGQLSGSSSTAQTAASQPRKHYYEKTHWEQHQLGTTASNIAKEHRRSEKVVGKVELCASKVSEAVAASLNFTAGEKREREASSDTDRTSQSPHILKANAAPSRDLRQAGASPQGSSQSSTGDDPIGSTTQTKLVSEKRHAKKHRRRRVRRFNKGGK
Protein: RRM domain-containing protein (B3KYC2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPMPWGGGYGGDMGYGAYGGGYGGGYGGPGAYGDFGAYGGGGFRGGMRGSPRGGMGGGGGFRGGPPGRGGMANRRGRGKRPGDGRGGPASKRDNGKPDFSADVNMSTF
Protein: Nutrient and stress factor 1 (Up in starvation protein 1) (Q12132)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor that participates in the transcriptional activation of glucose-repressed genes during exponential growth in non-fermentable carbon conditions. Also involved in salt-stress response.
Subcellular location: Nucleus {ECO:0000269|PubMed:18667581}. Note=Found in the nucleus in conditions under which NSF1 is actively transcribed, such as growth with non-fermentable carbon sources or salt stress.
Interaction partners:
- Transcriptional repressor XBP1
Sequence:
MENTTNRNTAGVLTSSNGNFATNSVAASTPKRSKSARRKTFKCTGYDGCTMSFTRAEHLARHIRKHTGEKPFQCPACLKFFSRVDNLKQHRESVHAHKNHHSTSSHQRKPSSSSLSSSSSASSSSSASSSTSYSDPYRKTNINSGNMPMMAENEKAPQIIHSSPEFITSTRSIPPISPRSIYNTQRQQQHQQQQHQQAPYYFPSHPITDSYYQYPLPSNNNTINYLPSVDVQYPLNVSPSSTSHPASEVIISSFPPRSMPSTSFKYKDSADFQARTTMNKYNIRPSNINVNTSNINNHLDSFSPPFSPSTTVAEAKPIILPQYQQAFSQPPNGNKNNNMSSSKNGGKGGENFKNTDDRNDNNNKKRSETLSESDISVNTNKKRLSVDYILT
Protein: Anoctamin-7 (New gene expressed in prostate homolog) (Transmembrane protein 16G) (Q14AT5)
Organism: Mus musculus (Mouse)
Function: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q6IWH7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6IWH7}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6IWH7}. Note=Concentrates at sites of cell-cell contact. Shows an intracellular localization. {ECO:0000250|UniProtKB:Q6IWH7}.
Interaction partners:
Sequence:
MLRGQAREEDSVVLIDMASPEAGNGCSYGSTAQASEAGKQQVAPSRVGSSAKPPIDFVLVWEEDLRNQENPTKDKTDTHEVWRETFLENLCLAGLKIDQHDVQDEAAAVHYILLRAPWAVLCYYAEDLRLKLPLQELPNQASNWSATLLEWLGIPNILLEHVPDTPPEYYSCQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGHEKKGLFGIDQLLAEGVFSAAFPLHDGPFSAVPESSQVLGLIQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTVVFLVGCFLVFSDIPTQELCHSSDSFDMCPLCSDCSFWLLSSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPRPQFAATAPMTALNPITGEDEPYFPEKNRVRRMLAGSVVLLMMVAVVIMCLVSVILYRAVMAIIVSRSDNAFLSAWASRIASLTGSVVNLVFILILSKVYVLLAQVLTRWEMHRTQTEFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGNYHTLFGIRNEECPAGGCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKFSRGKKAGTGTHPAPWEADYELLPCEGLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILTGLTHLAVISNAFLLAFSSDFLPRVYYSWTHAPDLHGFLNFTLARAPPTFTSAHNRTCRYRAFRDDDGHYSPTYWTLLAIRLAFVIVFEHVVFSIGRVLDLLVPDIPESVEIKVKREYYLAKQALAENEALLGATGVKDDQPPSSEPSLGLPA
Protein: Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) (P37231)
Organism: Homo sapiens (Human)
Function: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity).
Subcellular location: Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Nuclear receptor corepressor 1
- Nuclear receptor corepressor 2
- Retinoic acid receptor RXR-alpha
- Mediator of RNA polymerase II transcription subunit 1
- Nuclear receptor coactivator 1
- CREB-binding protein
- Nuclear receptor coactivator 2
- Transcription factor p65
- NAD-dependent protein deacetylase sirtuin-1
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Protein: Homeobox protein Nkx-6.2 (Q8CF07)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDANRPGAFVLSSAPLAALHNMAEMKTSLFPYALQGPAGFKTPALGSLGAQLPLGTPHGISDILGRPVGAAGGGLLGSLPRLNGLASSAGVYFGPAAAVARGYPKPLAELPGRPPIFWPGVVQGSPWRDPRLAGSAQAGGVLDKDGKKKHSRPTFSGQQDLRAGEDFRADQVFGRPRARAACLLSGHDREPSEGVVPESADQVAQAARGRDGVG
Protein: HssA/B-like protein 33 (Protein 2C) (P15648)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Peptidase A1 domain-containing protein
- Probable inactive serine/threonine-protein kinase fnkD
- Endoglucanase
- Uncharacterized protein
Sequence:
MTLFSSISSMSSSMTSSRSSFSSFGSGTSMGSNSIACSVGSGGGGCGSGSGGCGDLTGGAKSSGGSCGGKGGPHNHGHGNGHGPHGHGGKGSGGSCSC
Protein: Plexin domain-containing protein 1 (Tumor endothelial marker 3) (Tumor endothelial marker 7) (Q8IUK5)
Organism: Homo sapiens (Human)
Function: Plays a critical role in endothelial cell capillary morphogenesis.
Subcellular location: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
Interaction partners:
- Endosialin
- GTP-binding protein Rhes
Sequence:
MRGELWLLVLVLREAARALSPQPGAGHDEGPGSGWAAKGTVRGWNRRARESPGHVSEPDRTQLSQDLGGGTLAMDTLPDNRTRVVEDNHSYYVSRLYGPSEPHSRELWVDVAEANRSQVKIHTILSNTHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDVIHRMLTATQYVAPLMANFNPGYSDNSTVVYFDNGTVFVVQWDHVYLQGWEDKGSFTFQAALHHDGRIVFAYKEIPMSVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRSIFEYHRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGTPVHLGTIVGIVLAVLLVAAIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRSHPDHSTYAEVEPSGHEKEGFMEAEQC
Protein: Wide awake, isoform C (A0A0B4K6W6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MERRKALSSYAKFKDQQEAAAAVTPQKDNESDDSLPALRRSHSVRSSLRRLKNKLHSPALSMQSPFKLRTQLHMRNRSSRGSATLDKSKAAKALRMLGDLDAVAVLTTKVKGKNEFVPLKRAMNSDSCDHDELGIERLMSSLPVGAKLPRKACKLLQIPESYCRQAEVAPKATLDSDLEKTFSGEESSAVLADITRHAQQGIYGTTRMRTATIRKPMPYLNSHNILPQDKRDGDIDSVRLREKVVNPSGGNNNNQDNYPTYYPAPLLSTSRWSEQLTQHAAVAKIRTAISCHSQDLREMEFLLPHSRTDSQSNSQSQLCISRHSQPKNAKLRDDHDETGSSELDSPPLGDENASANGQLSVHRQPVQLRSKIPGNTPHPRASKMSKKQLKLAQAQLDKLTQNNLHLHALFSAVEHGHLEKARTILESTDVDVNSINNDGLSALDLAVLSNNRSMTRMLLQHGAVEGSQFSVDTIGTKLNGLLKDAESRIHDLSGPEGLCPPVFASRPSISSIIIGNSSASVTGCTGSEVEKQIGIWERRVKGLRRLQLGWDQARPPDAPASVVVDVTGDNSISVQILEPFEGAIGTKFKVQWSTRADFNNVVGESELLEWISFHGTMGAQCHISGLTQGRRYFLRAACGNVKGWGTYRTSVPASVVPSTWRDLDNREDRFVGRHRILDNLFTAVRLARPADVSELTLDPASAQRRNPKKKTTIKQLFSVTTKFQKTLRRGIYFSCIIHCDDKVLVTSEDFPPVIEVDESYPSALHMDYYWLMKVACTWEDVKSLRSDMERNLTSAVHFRTKLLSAVCQMQSALGITDLGQLYYKPLRDAQGTVVLTCVQSVKSQKAVSILNSRWVPVSKLQKKLGALHEDYTINELLISSIGDQLHYQQAALQRLEPGLYLGYLKMQCSIDQIQVVVPVKTPNVLPHCKVRENSHITAEEWQVLHRYSSDPLRLPLDFSAQGGDGASGATATTEVQRLFLYDLTNAMHKLFASMNIKIADATTHRLYDVEVIEHSPDISFLVVCPSAESSCAVPGQSELLLQRDDLASLSIQAFEMIHLRTYQPAIIQKYARLSCILELDTALATHSLREAFSSSELQAAKERLATLQELSASLTIVWKSVRWLMDVVAYARNKNAQPSLAMREILDFAQQRQDEAVATSAGGSANKQLLQLPIRESKFSKTGQGRGSWPGPGTSEDQSQNKPEHSKSEQNLELSAITPVEPASNQVPTQQQQPQQQSQQQQLLQVSNISEYAGSICSEVSFRKNSGDSMSSTYTSRSFYSAVDSASDGNSTNSVFAIPPSRSDDTLADALRHSQAVAAQRKRTSSNIASHTNPLITVHSSSSAPYLAGSSVSLRSGNGAFATDLEHKPLKPATKAASSANLREGGPYLKSTLAELRAVGGEEPVASTSKASSMKSLSRQSSEEDSASCSSLNAEQTSGIIQVYTAYSTGLASGTSLKIHVTPKTTAREVINLVVKQLNMAVVLKGNNGPIYGPEMLENFCLVAVIGARERCLRDDFKPLQLQNPWKKGRLYVRKKHELLAAIEHSNRKSHLI
Protein: Protein ABCI12, chloroplastic (ABC transporter I family member 12) (ABC transporter ABCI.12) (AtABCI12) (Q944H2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18431481}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- ABC transporter I family member 10
- ABC transporter I family member 11, chloroplastic
- Protein ABCI7, chloroplastic
- Iron-sulfur cluster assembly SufBD family protein ABCI9
- Iron-sulfur cluster assembly SufBD family protein ABCI8, chloroplastic
- Protein TRIGALACTOSYLDIACYLGLYCEROL 2, chloroplastic
- Protein TIC 21, chloroplastic
- ABC transporter I family member 6, chloroplastic
- ABC transporter I family member 19
- ABC transporter I family member 1
Sequence:
MNHSNLANPTVSLTVTLIPKHPIRHLTSPIPNRNFTNPKLLFPLRLNETPSSSLAAKRVFIVRATVDGDGKTGNWVNRLPIPGLGAENVFRLISSATGSPIGQFISSPVTFLHSVDPRIKLVWLLTLVVLPARANLVVRLGLVLCTALLSILVLPRQVWIDQLARVSLLSGILFITLGLGSDGAPPMLQSRTPPSSITSLPNLPMSLSGYSYMLLKLGPLQFTRKGLSVGSTAACLTFIIFQSASICLATTTPEQLALALRWFLFPLTYIGVPVSEIILTLLLSLRFINLVFDEVRSVSLGIVSRRVNWQQLTVLETLDIFASFIRRIFKNIFRHAEQISQAMIVRGFRGESSSHKIYFFSGSSNKFADFASVLCLIGVISTALLSEYFLV
Protein: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) (F1LPV8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03221}.
Interaction partners:
- Succinate--CoA ligase subunit alpha, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Methylmalonyl-CoA mutase, mitochondrial
Sequence:
MASAVAIAAQAGKLLRERSLRPRLLAVRSQAGHLTPRRWLNLQEYQSKKLMSEHGVRVQRFFVASTAKEAQEAAKRLNAKEIVLKAQILAGGRGKGVHLTKDPKVVGQLAQQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSHNGPVLVGSPQGGVDIEEVAASSPELIFKEQIDIFEGIKDSQAQRMAENLGFLGSLKNQAADQIKKLYHLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAARYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKESQVYQAFKLLTSDPKVEAILVNIFGGIVNCAIIANGITKACQELELKVPLVVRLEGTNVQEAQNILKSSGLPITSAVDLEDAAKKAVASVAKK
Protein: AT-rich interaction domain 5A (A0A669KBH0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAPVKGNRKQSTEGDALDPPASPKPAGKQNGIQNPISLEDSPEAGGEREEEQEREEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPTSKPRKQYKMAKENRGDDGATERPKKAKEERRMDQMMPGKTKADAADPAPLPSQEPPRNSTEQQGLASGSSVSFVGASGCPEAYKRLLSSFYCKGTHGIMSPLAKKKLLAQCPPPQTLPGLICLARTTSHNLCSAPLLPPQHQAVGQPMVLCTLWSRQGPTTGRYCCQGALN
Protein: Hsp70 nucleotide exchange factor fes1 (O43030)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Elongation factor 3
- mRNA export factor elf1
- Endoplasmic reticulum chaperone BiP
- Probable heat shock protein ssa1
- Protein psi1
- Heat shock protein sti1 homolog
- Heat shock protein 104
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL29
- Small ribosomal subunit protein bS16m
Sequence:
MEKLLAFSTQLQAQGNSSNSPPDPKDLDPSVLDHIFGANPADEMRKAMDAIEDPSVPLDQKEIAFDNLEMLVEHIDNANNLVPLQLWPRLLKQLESPESTLRRLAAWTIATAVQNNPKSQQALIENDGLKILFGALKKEDSDETKNKVLYAITSELKLNEAGIALLDKIPNSWEMLIEILELKHSVMTKRVIFFFYALLIQEDKSKQIILQKAHEFQIPEKVYQFSLEHSVDEDCVTKSLHTLYLFQKNKVSVANTNELLKSLVQFKSEFPEIFTVDEWKAFHEALE
Protein: Bruno 1, isoform B (Bruno 1, isoform G) (FI19388p1) (Q8IP90)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Maternal effect protein oskar
- Protein bicaudal C
- FI20148p1
- RRM domain-containing protein
- RNA-binding protein squid
- NHP2-like protein 1 homolog
Sequence:
MLSSLDALAGKIATATPGTGAVTADSKNTQSLHHHHRLDYDYSAVEIEPPAEQLANSPRSERERLQQAQQAYEQQAQAELEFGLAEVDAKLTQLKSSHSLQHHHSHHHQLQRHTALNQQQQQLHHHQPHHNHHHHHPYQRPRPTSPPQQQTSSYQQQLSQLAALQDHHDLLQTQQELFHKQLATMQEYQRERERERERERERERERERERDRSSFIDNSDYDSQTEFKICLRDSAFGMSDKSSSATNSLPNSPIHSNNNNPSLLNNNNNNSNGTSSNNSLNVGNNNSNPSLGGSNSNALVSVGSNGIMSAAGLVNNNNNPCSANRNVVAMVDDDACFRLDTDATVTYGEKEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRHAALKAQDALHNVKTLNGMYHPIQMKPADSENRNERKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQIQANLWNLASNINIPLGQTATSVTTPILPNPPQQPSPVLGADAITPASIQLLQQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPMTVQNLAAIAAMTQPSLSNAAAAAAAATSPGSAQLTNTAALLWSDPNPMASAYMSTAAGLPQFGSASALSTSPLASVALSAAAAAAAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLSKCFGFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPKDSKPY
Protein: Cinnamyl alcohol dehydrogenase 7 (AtCAD7) (EC 1.1.1.195) (Cinnamyl alcohol dehydrogenase-like protein B) (Q02971)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
Interaction partners:
- Cinnamoyl-CoA reductase 1
- Aldehyde dehydrogenase family 2 member C4
- Cinnamoyl-CoA reductase 2
- Flavone 3'-O-methyltransferase 1
- F5F19.5 protein
- Peroxidase 68
- Peroxidase 67
- 1-Cys peroxiredoxin PER1
- Peroxidase 15
- Peroxidase 55
Sequence:
MGKVLEKEAFGLAAKDESGILSPFSFSRRATGEKDVRFKVLFCGICHTDLSMAKNEWGLTTYPLVPGHEIVGVVTEVGAKVKKFNAGDKVGVGYMAGSCRSCDSCNDGDENYCPKMILTSGAKNFDDTMTHGGYSDHMVCAEDFIIRIPDNLPLDGAAPLLCAGVTVYSPMKYHGLDKPGMHIGVVGLGGLGHVAVKFAKAMGTKVTVISTSERKRDEAVTRLGADAFLVSRDPKQMKDAMGTMDGIIDTVSATHPLLPLLGLLKNKGKLVMVGAPAEPLELPVFPLIFGRKMVVGSMVGGIKETQEMVDLAGKHNITADIELISADYVNTAMERLAKADVKYRFVIDVANTMKPTP
Protein: Vacuolar protein sorting-associated protein 51 homolog (Protein UNHINGED) (Q0WQ75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (By similarity). Required for vacuolar targeting and cellular trafficking. Involved in the regulation of vascular tissue patterning, probably by regulating PIN1 expression pattern, thus modulating auxin flux. Important to prevent PIN1 accumulation within margin cells, possibly by targeting PIN1 to the lytic vacuole. Regulates PIN1 and ATHB8 expression pattern in secondary veins.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:24757006}. Recycling endosome {ECO:0000250|UniProtKB:Q9UID3}. Prevacuolar compartment {ECO:0000269|PubMed:24757006}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex. {ECO:0000250|UniProtKB:Q9UID3}.
Interaction partners:
- Vacuolar protein sorting-associated protein 54, chloroplastic
- Vacuolar protein sorting-associated protein 52 A
- At2g27890
- Vacuolar protein sorting-associated protein 53 A
- Vacuolar protein sorting-associated protein 53 B
- Vacuolar protein sorting-associated protein 52 B
- Conserved oligomeric Golgi complex subunit 5
- Conserved oligomeric Golgi complex subunit 7
- Conserved oligomeric Golgi complex subunit 2
- Conserved oligomeric Golgi complex subunit 4
Sequence:
MATEAAPMDEKAKRMRDLLSSFYAPDPSISTSGSSINASFDNINSTSFDADQYMDLMIKKSNLEVLLQRHVQMAAEIKNLDTDLQMLVYENYNKFISATDTIKRMKSNIFGMEGNMDQLLQKIMSVQSKSDGVNTSLFEKREHIEKLHRTRNLLRKVQFIYDLPARLQKCIKSEAYGDAVRFYTGAMPILKVYGDTSFQDCRRASEEAIEIIIKNLQTKLFSDSESIQARAEAAVLLKQLDVPVDSLKAKLLEKLEQSLDGLQIKPEEASTLVEDDDSSNDTESNDQHPAKIHEDAVRGFSEAIRAYREIFPDSEERLFKLARALTAMHFEYMELYIKKRVSAADFLGIFRIVWEDVVLMDEVLPEAALSDLSAEAAQVTLKQFVARMFSHLQQDISDTLLKFDINQKEAVEGELLKVVLEASQKAVLQGTTNIFQDFRQLLDEKTGIFIKMKDLISGWIQKGSQDFFRSLEAQFLVLSGKTSSSNDIEGKSSDKIHAGLILVLAQLSVFIEQKVIPRVTEEIAASFSGGNSQAFENGPAFIPGELCRVFHAASEKLLQHYIDTRTQKVSVLLRKRFKTPNWVKHKEPREVHMYVDMFLHELEEVGKEVKQVLPQGTFRKHKRTDSNGSNTTTSSRSNTLHNDKMARSNSQRARSQLFETHLAKLFKQKVEIFTKVEFTQESVVTTTVKLCLKSLQEYVRLQTFNRSGFQQIQLDIQFLKAPLKEAVEDEAAIDFLLDEVIVAASERCLDVIPLEPPILDKLIQAKLAKSKEHNNNTVSS
Protein: Lipolysis-activating peptide 1-beta chain (BotLVP1-beta) (LVP1-beta) (P84809)
Organism: Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Function: The homodimer inhibits HMG-CoA reductase (HMGCR) (32% of inhibition produced by 0.6 uM), a glycoprotein involved in the control of cholesterol biosynthesis. The inhibitory effects of bumarsin are seen at much lower concentrations (0.6 uM) than that for statins such as atorvastatin (5 mM) and simvastatin (10 uM). In addition to inhibition of HMG-CoA reductase, this protein lowers cholesterol levels by inducing steroid hormone synthesis via StAR, and by increasing reverse cholesterol transport mediated by the induction of ABCA1 and APOA1 (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:15680238}.
Interaction partners:
Sequence:
MISVQVIFIAFISIIAFSMVCGGNVFPNRELGILYGCKGYGNAFCDKVCKMHLARGGGRCGEPNPVMWACECIDIDEDNGYFLNALEKQCPLLKG