wanglab/gogpt-training-data huggingface dataset:
Protein: Myosin motor domain-containing protein (C6KRJ0)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MENPLLARQIPRAYPYQNGNVVPPPPSSYRAPSPAPTSGDRRGLNRLPQESYTEPAVKNTKNNSEYLSPHRFNLDEQKAVIRHEKETAKNAINMLSDRLRSPVPQPTPPPPPPPVREEWVIRDSVERDPVTQGRIRGSFRKEPLVPQPPRPPVVAEKPAVKFVKAPWKLTIRKEMFYPGEVLNDIQIIDQVFAQIVEDCKKSYPYRIREQDRKQVETVLRQYEIPPSDLNNQSNIHPDVKVAVIELARLWPLYFNQVYEVVEKRPDESVSTIFAISEHGIRLIVHTPHDLENPLKIQDFFPFETIADVSLEANDILSVHVRHEDEENAYSAVRIKTNQAPQIKKTLDRCLSGGVVPKRKFVRALEDYVTSEVNHLSFKQGDVIELLQEPEGETPPVGNWLYGKIENRFGFLLAQYVDSTDGDNVPPIRHETSEDRDERVRFFDDEVPFSSERYTMIDFATKYFRKPKDKKKQETWAWEDISQIVRFSEKPISQSLLADLGNEESKYAVETFHAIMKFMGDEPLKKSESMTDVVFKVLLICHRQPTLRDEVYCQLIKQTTSNISQKPNSALRAWRLLTIITAYFPSSLTLKPYVLQYLGDNADEWQRPFHGTARICQTNMIQTFKYGGRKVLLNALEVQQITDGCQLRRQAFYISKDHNVSQTLRPITVAEEMIQELCNLLNVRSLHEQQEFSLCYTVGKDKHLNYCKNDNYLMDIITESEHKKLPFQFYLKRTVWVHPLRYDNAAYIDSMFDQVIDDYLRGSLISTNSLGQLTAATTEEIIKLAAYLFLLLPDNPKGLNAKTLPQIVPKSVIEPKHRHQEEMVTRISRQLKMFGGRMRPAEAKSHFLELLSTWPTFGVLHYRLKSVVENGHQLPEVILTINKSGIQLLQPKSKEVFKERNYDQIVSVESIRKTAYKIVRLVINTMQGEETLDIKTDEADEISHLIGQYMFVTGGAEERGSTEL
Protein: Dual specificity protein phosphatase Mpk3 (EC 3.1.3.16) (EC 3.1.3.48) (Drosophila MKP3) (DMKP3) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) (Q9VVW5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Negatively regulates the activity of members of the MAP kinase family in response to changes in the cellular environment. Has a specificity for the ERK family. Acts as negative regulator in a variety of developmental processes including cell differentiation and proliferation controlled by the Ras/ERK pathway. Suppresses the photoreceptor cell differentiation and wing vein formation. Required for proper oogenesis and early embryogenesis. Functions autonomously in a subset of photoreceptor progenitor cells in eye imaginal disks. Appears also to be required in surrounding non-neuronal cells for ommatidial patterning and photoreceptor differentiation. Plays a role in the maintenance of epithelial integrity during tracheal development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11742539}.
Interaction partners:
- Mitogen-activated protein kinase ERK-A
- Mitogen-activated protein kinase p38a
- protein-tyrosine-phosphatase
Sequence:
MPETEHETCSKEWLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCESSSHHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANATGVSPDSGIEFDRWTPSDTGLK
Protein: ATP synthase F(0) complex subunit 8 (A6L) (F-ATPase subunit 8) (P03929)
Organism: Bos taurus (Bovine)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Subcellular location: Mitochondrion membrane; Single-pass membrane protein.
Interaction partners:
- ATP synthase peripheral stalk subunit d, mitochondrial
- ATP synthase peripheral stalk subunit b, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase subunit e
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase F
Sequence:
MPQLDTSTWLTMILSMFLTLFIIFQLKVSKHNFYHNPELTPTKMLKQNTPWETKWTKIYLPLLLPL
Protein: Ephrin type-B receptor 1 (EC 2.7.10.1) (Q8CBF3)
Organism: Mus musculus (Mouse)
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P54762}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P54762}. Early endosome membrane {ECO:0000250|UniProtKB:P54762}. Cell projection, dendrite {ECO:0000269|PubMed:14691139}.
Interaction partners:
- Ephrin-B1
- Ephrin-B2
- Ephrin-B3
- Ephrin-A5
- Ephrin-A4
- Ephexin-1
- Ephrin-A1
- Ras GTPase-activating protein 1
- Ephrin type-B receptor 6
- Ephrin-A2
Sequence:
MALDCLLLFLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPSEASPICTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAAYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGVTLAGHQKKILSSIHSMRVQMNQSPSVMA
Protein: Transcription factor LRL2 (Basic helix-loop-helix protein 69) (AtbHLH69) (bHLH 69) (Protein DEFECTIVE REGION OF POLLEN 2) (Protein LJRHL1- LIKE 2) (AtLRL2) (Transcription factor EN 94) (Transcription factor bHLH69) (bHLH transcription factor bHLH069) (Q8S3D5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that regulates the development of root hairs. Transcription factor that regulates the development of sperm cells.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Transcription factor MYB3R-2
- Uncharacterized protein AT4g30970
- F-box/kelch-repeat protein SKIP30
- Shaggy-related protein kinase gamma
- Shaggy-related protein kinase alpha
- Extensin-like protein
- Transcription factor WER
Sequence:
MNSSSLLTPSSSPSPHLQSPATFDHDDFLHHIFSSTPWPSSVLDDTPPPTSDCAPVTGFHHHDADSRNQITMIPLSHNHPNDALFNGFSTGSLPFHLPQGSGGQTQTQSQATASATTGGATAQPQTKPKVRARRGQATDPHSIAERLRRERIAERMKSLQELVPNGNKTDKASMLDEIIDYVKFLQLQVKVLSMSRLGGAASASSQISEDAGGSHENTSSSGEAKMTEHQVAKLMEEDMGSAMQYLQGKGLCLMPISLATTISTATCPSRSPFVKDTGVPLSPNLSTTIVANGNGSSLVTVKDAPSVSKP
Protein: Regulator of G-protein signaling rgs-3 (Q18312)
Organism: Caenorhabditis elegans
Function: Modulates chemotaxis responses by regulating positively the sensitivity to CO2 levels in BAG neurons and by regulating negatively the sensitivity to quinine in ASH sensory neurons.
Interaction partners:
- RGS domain-containing protein
- RGS domain-containing protein
- Regulator of G-protein signaling 7
- Regulator of G-protein signaling rgs-10
- Regulator of G-protein signaling rgs-6
- Guanine nucleotide-binding protein subunit beta-2
- Regulator of G-protein signaling rgs-11
- Guanine nucleotide-binding protein subunit beta-1
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MWRSYKAETPELADETQEVDLNLHDSSESDHEGRQSRSASITSSTSAPASNDVTLQVPITNSSATSPTPSTGSMYFIAGMFDGKEKVNREQPPMPTTDGVEYPRAASWAAGNCANVLNDDKGKQLFRVFLFQSLAEENLAFLEAMEKLKKMKISDEKVAYAKEILETYQGSINLSSSSMKSLRNAVASETLDMEEFAPAIKEVRRLLENDQFPRFRRSELYLEYLEELLPRSYAEKWAQSFEGLLGNHVGRHHFRIFLRSIHAEENLRFWEAVVEFRSSRHKANAMNNLGKVILSTYLAEGTTNEVFLPFGVRQVIERRIQDNQIDITLFDEAIKHVEQVLRNDPYVRFLQSSQYIDLLSKLK
Protein: Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (Q8JG38)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity).
Subcellular location: Cell membrane; Single-pass type I membrane protein. Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded (By similarity). {ECO:0000250}.
Interaction partners:
- Putative fibroblast growth factor 1
- Fibroblast growth factor
- Fibroblast growth factor
- Fibroblast growth factor 8
- Fibroblast growth factor 17
- Fibroblast growth factor
- Fibroblast growth factor
- Fibroblast growth factor
- Son of sevenless homolog 1
- Fibroblast growth factor 8b
Sequence:
MFARGWLLGALLLMTLATVSVARPSLKIDLVNTSAPEEPPTKNQNCVPVLFSVHPGELLKLKCPLSGADDVVWTKDSSSLRPDNRTLVARDWLQISDATPKDSGLYSCSATGLRDCDVFSFIVNVTDAISSGDDEDDTERSDDVGADGEQMRLPYWTFPEKMEKKLHAVPAANTVKFRCAAAGNPKPKMRWLKNAKPFRQEDRMGGYKVRLQHWTLIMESVVPSDKGNYTCLVENQYGSIDHTYTLDVVERSPHRPILQAGLPANVTVQVGQDAKFVCKVYSDAQPHIQWLQHYTKNGSCCGPDGLPYVRVLKTAGVNTTDKEIEVLYLPNVTFEDAGEYTCLAGNSIGISYHTAWLTVHPAETNPIETDYPPDYVEIAIYCIGVFLIACMVVIVVVCRMRTSAKKPDFSSQPAVHKLTKQIPLRRQVTVSSDSSSSMSSSTPLVRITTRRSSAHDDPIPEYDLPEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDLDRILTLATNEEYLDLCAPVEQYSPSFPDTRSSCPSGDDSVFSHDPLADEPCLPKYQHINGGIKT
Protein: Secreted effector protein SifA (Q56061)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.
Subcellular location: Secreted. Host cytoplasm. Host cell membrane. Note=Secreted via type III secretion system 2 (SPI-2 T3SS), and delivered into the host cytoplasm. It associates with membranes and colocalizes with microtubules along the length of Sifs in infected cells.
Interaction partners:
- Secreted effector protein PipB
- Secreted effector protein SseJ
- Secreted effector protein PipB2
- Secretion system effector
- Secretion system effector
- Secreted effector protein sopD2
- Inositol phosphate phosphatase SopB
- E3 ubiquitin-protein ligase SspH2
- E3 ubiquitin-protein ligase SopA
- SPI-2 type 3 secretion system translocon protein SctB
Sequence:
MPITIGNGFLKSEILTNSPRNTKEAWWKVLWEKIKDFFFSTGKAKADRCLHEMLFAERAPTRERLTEIFFELKELACASQRDRFQVHNPHENDATIILRIMDQNEENELLRITQNTDTFSCEVMGNLYFLMKDRPDILKSHPQMTAMIKRRYSEIVDYPLPSTLCLNPAGAPILSVPLDNIEGYLYTELRKGHLDGWKAQEKATYLAAKIQSGIEKTTRILHHANISESTQQNAFLETMAMCGLKQLEIPPPHTHIPIEKMVKEVLLADKTFQAFLVTDPSTSQSMLAEIVEAISDQVFHAIFRIDPQAIQKMAEEQLTTLHVRSEQQSGCLCCFL
Protein: WRKY transcription factor 22 (WRKY DNA-binding protein 22) (O04609)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor involved in the expression of defense genes in innate immune response of plants. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Activates WRKY 29, SIRK and its own promoters.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 6
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 9
- Cytochrome b-c1 complex subunit 9, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MADDWDLHAVVRGCSAVSSSATTTVYSPGVSSHTNPIFTVGRQSNAVSFGEIRDLYTPFTQESVVSSFSCINYPEEPRKPQNQKRPLSLSASSGSVTSKPSGSNTSRSKRRKIQHKKVCHVAAEALNSDVWAWRKYGQKPIKGSPYPRGYYRCSTSKGCLARKQVERNRSDPKMFIVTYTAEHNHPAPTHRNSLAGSTRQKPSDQQTSKSPTTTIATYSSSPVTSADEFVLPVEDHLAVGDLDGEEDLLSLSDTVVSDDFFDGLEEFAAGDSFSGNSAPASFDLSWVVNSAATTTGGI
Protein: Zinc finger protein GLIS1 (GLI-similar 1) (Q8NBF1)
Organism: Homo sapiens (Human)
Function: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells. Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8K1M4}.
Interaction partners:
- Cornifin-B
Sequence:
MAEARTSLSAHCRGPLATGLHPDLDLPGRSLATPAPSCYLLGSEPSSGLGLQPETHLPEGSLKRCCVLGLPPTSPASSSPCASSDVTSIIRSSQTSLVTCVNGLRSPPLTGDLGGPSKRARPGPASTDSHEGSLQLEACRKASFLKQEPADEFSELFGPHQQGLPPPYPLSQLPPGPSLGGLGLGLAGRVVAGRQACRWVDCCAAYEQQEELVRHIEKSHIDQRKGEDFTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHAGPDTEADVLTECLVLQQLHTSTQLAASDGKGGCGLGQELLPGVYPGSITPHNGLASGLLPPAHDVPSRHHPLDATTSSHHHLSPLPMAESTRDGLGPGLLSPIVSPLKGLGPPPLPPSSQSHSPGGQPFPTLPSKPSYPPFQSPPPPPLPSPQGYQGSFHSIQSCFPYGDCYRMAEPAAGGDGLVGETHGFNPLRPNGYHSLSTPLPATGYEALAEASCPTALPQQPSEDVVSSGPEDCGFFPNGAFDHCLGHIPSIYTDT
Protein: EP1-like glycoprotein 2 (Curculin-like (Mannose-binding) lectin family protein) (Q9ZVA2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000269|PubMed:23738689}. Secreted, cell wall {ECO:0000269|PubMed:18796151}.
Interaction partners:
- Mannan endo-1,4-beta-mannosidase 3
- Protein ZINC INDUCED FACILITATOR 1
Sequence:
MSRFAILVTLALAIATVSVVIAQVPPEKQFRVVNEGEFGEYITEYDASYRFIESSNQSFFTSPFQLLFYNTTPSAYILALRVGLRRDESTMRWIWDANRNNPVGENATLSLGRNGNLVLAEADGRVKWQTNTANKGVTGFQILPNGNIVLHDKNGKFVWQSFDHPTDTLLTGQSLKVNGVNKLVSRTSDSNGSDGPYSMVLDKKGLTMYVNKTGTPLVYGGWPDHDFRGTVTFAVTREFDNLTEPSAYELLLEPAPQPATNPGNNRRLLQVRPIGSGGGTLNLNKINYNGTISYLRLGSDGSLKAYSYFPAATYLKWEESFSFFSTYFVRQCGLPSFCGDYGYCDRGMCNACPTPKGLLGWSDKCAPPKTTQFCSGVKGKTVNYYKIVGVEHFTGPYVNDGQGPTSVNDCKAKCDRDCKCLGYFYKEKDKKCLLAPLLGTLIKDANTSSVAYIKY
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Q8MQX4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAKLKKLHMSSNLDDLEKMSIIPDLRSKGMKILLNTARKLYMTAEEYRLDGDEELAYITYMKYFNMLTAIHKKSDYPSHKTTVRQMLGDTESNRRIMDTLEEIINSLRHRYAQQHQAPEPIAPDLVSNGRAGVDSPITQPTQYARLGLITCQDLYRRMQEKSVLVMDCRPSADYEDSHLTYYCAFNVPEELITPGMSAGRLQARLSSSAKASWASRSVKDSVVLMDWNTKDAQPATNTAISTLLDILKNWDPDVTYRAPIQIVEGGYEYFIMMYPTHCTNPSVQAPQQNNNDIETIDDIEYPSIHDITMKEDISAKDFRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKMWKRQAAEGDGLNATEDQELHFRILQLESKAQDYIVENNRLREELSRIQELHNVTQQLSQKEVEATRNIESKIRERQRLDEQHELERQERERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERIHGWKCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFYTWLPPMQVPL
Protein: Kinesin heavy chain isoform 5A (EC 5.6.1.3) (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) (Q6QLM7)
Organism: Rattus norvegicus (Rat)
Function: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:7514426}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7514426}. Perikaryon {ECO:0000269|PubMed:7514426}. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region.
Interaction partners:
- Kinesin light chain
- Kinesin light chain 1
- Kinesin light chain 4
- Kinesin light chain 3
- Kinesin heavy chain isoform 5C
- Kinesin-1 heavy chain
- Trafficking kinesin-binding protein 2
- Neurofilament light polypeptide
- Platelet-activating factor acetylhydrolase IB subunit alpha
- Nuclear distribution protein nudE-like 1
Sequence:
MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVIIGGKPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVRGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENIETEQKLSGKLYLADLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEDSALAAEICEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKEEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESEPQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQTVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDAEEVKKALELQMENHREAHHRQLARLRDEINEKQKTIDELKDLDQKLQLELEKLQADYERLKNEENEKSAKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTEVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNNLFQNYQNLHLQAAPSSTSDVYFASNGATSVAPLASYQKANTDNGNATDINDNRSDLPCGYEAEDPAKLFPLHQETAAS
Protein: Tsc22d2 protein (Q148S0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MTAAVQPTQLQGAVAGGALPGPVGQGLPPPPNVNLAQPVALAAQPGPAGGSSLSQQFAYPQPQIPPGHLLPMQPSGQSEYLPPHVALQPPSPAQPLSTSASATSASAASFPLGSGQSVSSLGAQMMGASAQPSEAVAPGPVPVGQAAPCQPAGVAPAALGGVVQPGSGLTGVGQPQPVQPPQQMGGSGQLPAVPGGPHTVVPGVPNVPAAVPVPSVPSVPTTSVTMPNVPAPLGQSQQLSSHTPVSRSSSVIQQVGSPLAQGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQAPLSLIAESKPVVKPPVADALTNPLQLTPMNSLATSVFSIAIPVDGDEDSASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNNDQLSQLPAQQANPGSTSQQQAMIAQPPQPTQPPQQPNVSSA
Protein: Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (mSART-3) (Tumor-rejection antigen SART3) (Q9JLI8)
Organism: Mus musculus (Mouse)
Function: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (By similarity). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:12578909}. Nucleus, Cajal body {ECO:0000269|PubMed:12578909}. Nucleus speckle {ECO:0000250|UniProtKB:Q15020}. Cytoplasm {ECO:0000250|UniProtKB:Q15020}.
Interaction partners:
- U6 snRNA-associated Sm-like protein LSm8
- U6 snRNA-associated Sm-like protein LSm2
- U6 snRNA-associated Sm-like protein LSm4
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm5
- U6 snRNA-associated Sm-like protein LSm6
- Ubiquitin carboxyl-terminal hydrolase 4
- Ubiquitin carboxyl-terminal hydrolase 15
- U4/U6 small nuclear ribonucleoprotein Prp4
- U4/U6 small nuclear ribonucleoprotein Prp31
Sequence:
MATTAASSASEPEVEPQAGPEAEGEEDEAKPAGVQRKVLSGAVAAEAAEAKGPGWDLQREGASGSDGDEEDAMASSAESSAGEDEWEYDEEEEKNQLEIERLEEQLSINGYDYNCHVELIRLLRLEGELSRVRAARQKMSELFPLTEELWLEWLHDEISMAMDGLDREHVYELFERAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLAIWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYEMEATFAEYEEWSEEPMPESVLQSYQKALGQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQYLDRQLKVKDLVLSVHSRAVRNCPWTVALWSRYLLAMERHGLDHQTISATFENALSAGFIQATDYVEIWQVYLDYLRRRVDFRQDSSKELEELRSMFTRALEYLQQEVEERFSESGDPSCLIMQSWARVEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGTLEDWDLAIQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKKVRAEKKALKKKKKTRGADKRREDEDEENEWGEEEEEQPSKRRRTENSLASGEASAMKEETELSGKCLTIDVGPPSKQKEKAASLKRDMPKVAHDSSKDSVTVFVSNLPYSIEEPEVKLRPLFEVCGEVVQIRPIFSNRGDFRGYCYVEFGEEKSAQQALELDRKIVEGRPMFVSPCVDKSKNPDFKVFRYSTTLEKHKLFISGLPFSCTKEELEDICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIRENVIKVAISNPPQRKVPEKPEVRTAPGAPMLPRQMYGARGKGRTQLSLLPRALQRQGAAPQAENGPAPGPAVAPSVATEAPKMSNADFAKLLLRK