wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein ycf15 (ORF77) (P56809)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- ATP synthase subunit 9
- Alpha/beta-Hydrolases superfamily protein
- ATP synthase subunit 9, mitochondrial
- Probable disease resistance protein RF9
- ATP synthase subunit delta', mitochondrial
- Disease resistance protein RFL1
Sequence:
MLLLKHGRIEILDQNTMYGWYELPKQEFLNSEQPELLLTTSKKFPLIKDGNPLENQKYACRIKLLLLSVPITNQLNN
Protein: Transcriptional regulatory protein BasR (P30843)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Sensor protein BasS
- Signal transduction protein PmrD
- Phosphoethanolamine transferase EptA
- Sensor protein PhoQ
- PhoP/PhoQ regulator MgrB
- Sensor protein QseC
- Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase
- UDP-glucose 6-dehydrogenase
- UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase aminotransferase)
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Sequence:
MKILIVEDDTLLLQGLILAAQTEGYACDSVTTARMAEQSLEAGHYSLVVLDLGLPDEDGLHFLARIRQKKYTLPVLILTARDTLTDKIAGLDVGADDYLVKPFALEELHARIRALLRRHNNQGESELIVGNLTLNMGRRQVWMGGEELILTPKEYALLSRLMLKAGSPVHREILYNDIYNWDNEPSTNTLEVHIHNLRDKVGKARIRTVRGFGYMLVANEEN
Protein: Candida glabrata strain CBS138 chromosome G complete sequence (Q6FTB3)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome E complete sequence
- Candida glabrata strain CBS138 chromosome H complete sequence
- Candida glabrata strain CBS138 chromosome H complete sequence
- GrpE protein homolog
- Eukaryotic peptide chain release factor GTP-binding subunit
- Heat shock protein homolog SSE1
- Candida glabrata strain CBS138 chromosome G complete sequence
- Candida glabrata strain CBS138 chromosome L complete sequence
- Candida glabrata strain CBS138 chromosome J complete sequence
Sequence:
MNDETQFTERALHILTVAQKLATDHQHPQLQPIHLLAAFIETPEDGSVAYLQNLIEKGRYDYDLFKKTVNKALVRVPQQHPAPAEVTPSYALGKVIQDAVKIQKQQKDSFIAQDHLLFALFNDASIKQVFKDAGVDTEAVKQQALELRGSQRIDSRGADTNTPLEYLGKYAIDMTEQARQGKLDPVIGREEEIRSTIRVLARRIKSNPCLIGEPGIGKTAIIEGVAQRIIDDDVPTILQGSKLFSLDLAALTAGAKYKGDFEERLKGVLKEVEESKTLIVLFIDEIHMLMGNGKDDAANILKPALSRGHLKVIGATTNNEYRSIVEKDGAFERRFQKIDVQEPTIRQTVAILRGLQPKYEIHHGVRILDSALVTASQLAKRYLPYRRLPDSAIDLVDISCAGVAVARDSKPEELDSKERQLQLLQVEIKALERDKDADCTTKDRLKQAKKREASLIEELEPLRQRYNEERKGHEELTKLKKKLDELENKALDAERRYDTATAADLRYFAIPDIKKKIDDLENQVAEEEQRAGANSMIQNVVDSDTISETAARLTGIPVKKLSESENEKLIHMERDLSSEVVGQMEAVKAVSNAVRLSRSGLANPRQPASFMFLGLSGSGKTELAKKIAGFLFNDENMMIRVDCSELSEKYSVSKLLGTTAGYVGYEEGGFLTNQLQYKPYSVLLFDEIEKAHPDVLTILLQMLDDGRITSGQGKTIDCSNCIVIMTSNLGAQYINLQKGSKIMDETKTLVMEAVKQHFRPEFLNRISSIVVFNKLSRKAIHKIVDIRLKEIEDRFEMNDKHYKLELTPEAKDFLAKYGYSEDMGARPLNRLIQTEILNKMALRILKGEIQDKETVKVVLKVGKERGSASTEDEEESLDVLPNHEATIAIDNDTMDIDDDDDDDAVDVD
Protein: H-2 class II histocompatibility antigen, E-D alpha chain (H2-IE-alpha) (P01904)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MATIGALVLRFFFIAVLMSSQKSWAIKEEHTIIQAEFYLLPDKRGEFMFDFDGDEIFHVDIEKSETIWRLEEFAKFASFEAQGALANIAVDKANLDVMKERSNNTPDANVAPEVTVLSRSPVNLGEPNILICFIDKFSPPVVNVTWLRNGRPVTEGVSETVFLPRDDHLFRKFHYLTFLPSTDDFYDCEVDHWGLEEPLRKTWEFEEKTLLPETKENVMCALGLFVGLVGIVVGIILIMKGIKKRNVVERRQGAL
Protein: Polyphosphatidylinositol phosphatase INP53 (Suppressor of PMA1 protein 2) (Synaptojanin-like protein 3) [Includes: SAC1-like phosphoinositide phosphatase (EC 3.1.3.-); Phosphatidylinositol 4,5-bisphosphate 5-phosphatase (EC 3.1.3.36)] (Q12271)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Dephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11094088, ECO:0000269|PubMed:14562095}. Note=Cytoplasmic punctate structures. Hyperosmotic stress causes translocation to actin patches.
Interaction partners:
- AP-1 complex subunit gamma-1
- Phosphoinositide 3-phosphatase
- Polyphosphatidylinositol phosphatase INP52
- Phosphatidylinositol 4-kinase PIK1
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 4-kinase STT4
- Phosphatidylinositol 4-phosphate 5-kinase MSS4
- Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1
- Clathrin heavy chain
Sequence:
MIIFVSEEPERRLAIVSNLYALVLKPVGKKPSDKPLCAIELLQKNDLKKYGFKRLTSHEIFGVIGLIEVNGLLFVGAITGKSKVAQPCPGETVNKIFAVDFFCLNDNSWDFIEIDSSGYPVLPETASTEYQDALPKHPCYELKKLLSNGSFYYSSDFDLTSTLQHRGYGQHSLSTDTYEEEYMWNSFLMQEMITYRDHLDTNLKQILDDEGFLTTVIRGFAETFVSYVKKLKVALTIISKQSWKRAGTRFNARGVDDEANVANFVETEFIMYSSQYCYAFTQIRGSIPVFWEQGTSLINPRVQITRSFEATQPVFDKHIMKSVEKYGPVHVVNLLSTKSSEIELSKRYKEHLTHSKKLNFNKDIFLTEFDFHKETSQEGFSGVRKLIPLILDSLLSSGYYSYDVREKKNISEQHGIFRTNCLDCLDRTNLAQQIISLAAFRTFLEDFRLISSNSFIDDDDFVSKHNTLWADHGDQISQIYTGTNALKSSFSRKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDTLLGRLPYQKAVQLYDPVNEYVSTKLQSMSDKFTSTSNINLLIGSFNVNGATKKVDLSKWLFPIGEKFKPDIVVLGLQEVIELSAGSILNADYSKSSFWENLVGDCLNQYDDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATKKTGFRGMAGNKGAVSIRFEYGATSFCFVNSHLAAGATNVEERRSDYESIVRGITFTRTKMIPHHDSIFWLGDMNYRINLPNEDVRRELLNQEEGYIDKLLHFDQLTLGINSGSVFEGFKEPTLKFRPTYKYDPGTGTYDSSEKERTPSWTDRIIYKGENLLPLSYSDAPIMISDHRPVYAAYRAKITFVDDKERLSLKKRLFTEYKQEHPEEPGSLISDLLSLDLDNKSTDGFKSSSESSLLDIDPIMAQPTASSVASSSPVSSASASLQPVRTQNSSQSRTPIKKPVLRPPPPPAHKSVSAPAPSTSKEKSPTPQTSTASLSSVTKNIQENKPLAQNRRIPPPGFSQNILTPKSTSNLASPMSSKVDLYNSASESTRSAQDARQQTPTAFAASRDVNGQPEALLGDENPIEPEEKAKLNHMTLDSWQPLTPK
Protein: Universal stress protein Rv2624c (USP Rv2624c) (P9WFD5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Putative zinc metalloprotease Rip3
- Hypoxic response protein 1
- Universal stress protein Rv2028c
- Probable cation-transporting ATPase F
- ATP-dependent 6-phosphofructokinase isozyme 2
- Oxygen sensor histidine kinase response regulator DevS/DosS
- Putative NAD
- Putative uncharacterized protein Rv2628
- Universal stress protein Rv2623
- Nitrate reductase-like protein NarX
Sequence:
MSGRGEPTMKTIIVGIDGSHAAITAALWGVDEAISRAVPLRLVSVIKPTHPSPDDYDRDLAHAERSLREAQSAVEAAGKLVKIETDIPRGPAGPVLVEASRDAEMICVGSVGIGRYASSILGSTATELAEKAHCPVAVMRSKVDQPASDINWIVVRMTDAPDNEAVLEYAAREAKLRQAPILALGGRPEELREIPDGEFERRVQDWHHRHPDVRVYPITTHTGIARFLADHDERVQLAVIGGGEAGQLARLVGPSGHPVFRHAECSVLVVRR
Protein: Peptide transporter 3 (Oligopeptide transporter 3) (O01840)
Organism: Caenorhabditis elegans
Function: Neuron-specific, H(+)-coupled oligopeptide transporter with broad specificity towards di- and tripeptides in a Na(+) and Cl(-)-independent manner. Shows H(+) channel activity in the absence of peptide substrates.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Receptor-type guanylate cyclase gcy-13
- NMDA-type ionotropic glutamate receptor NMR-2
- Nuclear hormone receptor family member fax-1
- LITAF domain-containing protein
- Neuronal immunoglobulin domain-containing protein rig-3
Sequence:
MEEKSLLQKLRSYPPAVFFMLGNEFCERFSFYGMKTILFIYLITEHEFSPSKATFIYHLFTCIAYLTPLIGSIMADSVFGRFKVILYGSSIYVVGHVLLSLGAVPFLSYPIRSSLDFSGLFVIAFATGCIKPCVSAFAADQFTEDQKDLRSQFFSFFYFAINGGSLFAIIITPILRGRVQCFGNAHCFPLAFGVPGVLMLLALILFLMGWSMYKKHPPSKENVGSKVVAVIYTSLRKMVGGASRDKPVTHWLDHAAPEHSQKMIDSTRGLLNVAVIFCPLIFFWALFDQQGSTWVLQARRLDGRVGHFSILPEQIHAINPVCVLILVPIFEGWVYPALRKITRVTPLRKMAVGGLLTAFSFAIAGVLQLKVNETMEFPPSLGRIYLQRVGNESLISDFRYKSDGRLIGDGMLPKGRTELDAGIYTFNTGLKNESQEIDISTPNKGYVMAVFRLKDAVEVVKFDYKVEKTDNGATRVFVVTAREDADTLVYAINKKGKILSSCELKSGSYVDVIPGIISDPNVRLYWGPKNSCSGVDCPNTVTLNAQMGAVHVLHIHPSTTEGDFNLLVRPNSVSILWSLPQYIIITLGEVLLSVTGLEFAYSQAAPNMKSVLTAMWLLTVFAGNLIDMMISGTRLIPHPALEFFFYSTLMVIVMGVFILLAMQYTYVEDNDDEITITESEKKDVIALTEIESGTATSDKKE
Protein: Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80) (Q9NVC6)
Organism: Homo sapiens (Human)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 14
Sequence:
MSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGSGSEEEEAAGTEGDAQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQVPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATEKQCPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDNKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL
Protein: Palmitoyltransferase ZDHHC16 (EC 2.3.1.225) (Abl-philin 2) (Zinc finger DHHC domain-containing protein 16) (DHHC-16) (Q969W1)
Organism: Homo sapiens (Human)
Function: Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6. Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function. May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:17123647}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9ESG8}.
Interaction partners:
- Tyrosine-protein kinase ABL1
Sequence:
MRGQRSLLLGPARLCLRLLLLLGYRRRCPPLLRGLVQRWRYGKVCLRSLLYNSFGGSDTAVDAAFEPVYWLVDNVIRWFGVVFVVLVIVLTGSIVAIAYLCVLPLILRTYSVPRLCWHFFYSHWNLILIVFHYYQAITTPPGYPPQGRNDIATVSICKKCIYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGSWDLFREAYAAIEKMKQLDKNKLQAVANQTYHQTPPPTFSFRERMTHKSLVYLWFLCSSVALALGALTVWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDNWKVFLGVDTGRHWLTRVLLPSSHLPHGNGMSWEPPPWVTAHSASVMAV
Protein: Large ribosomal subunit protein uL14m (54S ribosomal protein L38, mitochondrial) (YmL38) [Cleaved into: 54S ribosomal protein L34, mitochondrial (YmL34)] (P35996)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein uS17m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein uL13m
Sequence:
MIFLKSVIKVIDNSGAQLAECIKVIRKGSPKSPAMVGDRIVCVIQKAKPLTQNITGTANTNRVKKGDICHAIVVRSKQRNMCRKDGSTVAFGDTACVLINKNTGEPLGTRIMANDGCVDRTLKDKGYNKICSLASRVI
Protein: Pentatricopeptide repeat-containing protein At2g03880, mitochondrial (Q9SI53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Zinc finger, C3HC4 type
- Phosphoglycerate mutase family protein
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- Transcription factor bHLH118
- Uncharacterized tatC-like protein ymf16
Sequence:
MKSVMSKIKLFRPVVTLRCSYSSTDQTLLLSEFTRLCYQRDLPRAMKAMDSLQSHGLWADSATYSELIKCCISNRAVHEGNLICRHLYFNGHRPMMFLVNVLINMYVKFNLLNDAHQLFDQMPQRNVISWTTMISAYSKCKIHQKALELLVLMLRDNVRPNVYTYSSVLRSCNGMSDVRMLHCGIIKEGLESDVFVRSALIDVFAKLGEPEDALSVFDEMVTGDAIVWNSIIGGFAQNSRSDVALELFKRMKRAGFIAEQATLTSVLRACTGLALLELGMQAHVHIVKYDQDLILNNALVDMYCKCGSLEDALRVFNQMKERDVITWSTMISGLAQNGYSQEALKLFERMKSSGTKPNYITIVGVLFACSHAGLLEDGWYYFRSMKKLYGIDPVREHYGCMIDLLGKAGKLDDAVKLLNEMECEPDAVTWRTLLGACRVQRNMVLAEYAAKKVIALDPEDAGTYTLLSNIYANSQKWDSVEEIRTRMRDRGIKKEPGCSWIEVNKQIHAFIIGDNSHPQIVEVSKKLNQLIHRLTGIGYVPETNFVLQDLEGEQMEDSLRHHSEKLALAFGLMTLPIEKVIRIRKNLRICGDCHVFCKLASKLEIRSIVIRDPIRYHHFQDGKCSCGDYW
Protein: Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein homolog) (Q64446)
Organism: Mus musculus (Mouse)
Function: Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P35670}; Multi-pass membrane protein {ECO:0000255}. Late endosome {ECO:0000250|UniProtKB:P35670}. Note=Predominantly found in the trans-Golgi network (TGN). Not redistributed to the plasma membrane in response to elevated copper levels. {ECO:0000250|UniProtKB:P35670}.
Interaction partners:
- Copper transport protein ATOX1
- Copper chaperone for superoxide dismutase
- High affinity copper uptake protein 1
- Copper-transporting ATPase 1
- Ceruloplasmin
- Cytochrome c oxidase copper chaperone
- COMM domain-containing protein 1
- Protein SLC31A2
- COMM domain-containing protein 1
- Natural resistance-associated macrophage protein 2
Sequence:
MDPRKNLASVGTMPEQERQVTAKEASRKILSKLALPGRPWEQSMKQSFAFDNVGYEGGLDSTSSSPAATDVVNILGMTCHSCVKSIEDRISSLKGIVNIKVSLEQGSATVRYVPSVMNLQQICLQIEDMGFEASAAEGKAASWPSRSSPAQEAVVKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAIKNRTAPLRLGPIDVNKLESTNLKKETVSPVQISNHFETLGHQGSYLATLPLRIDGMHCKSCVLNIEGNIGQLPGVQNIHVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSLPDGVEENEPQSGSSQRHQEQGPGRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGSVQKMAPDTRGLPTHQGPGHSSETPSSPGATASQKCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVMEDNTVSEGDIELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIVGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMVYMLIPSSTPQETMVLDHNIIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHRSANMDVLIVLATTIAYAYSLVILVVAVAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLLKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIVIGFVDFGVVQKYFPSPSKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGVLIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRFLLLADVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYSTDFQAVPGCGISCKVSNVEGILARSDLTAHPVGVGNPPTGEGAGPQTFSVLIGNREWMRRNGLTISSDISDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRVNLVLALIYNMVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLERYEAQAHGRMKPLSASQVSVHIGMDDRRRDSPRATAWDQVSYVSQVSLSSLTSDRLSRHGGAAEDGGDKWSLLLSDRDEEQCI
Protein: Transcriptional activator HAA1 (Q12753)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulates the transcription of a set of genes, many of which encode membrane proteins. Among the genes regulated are YGR138C and YRO2. Does not seem to be dependent on copper.
Subcellular location: Nucleus {ECO:0000269|PubMed:11504737}.
Interaction partners:
- Polyamine transporter 2
- Polyamine transporter 3
- Weak acid resistance protein 1
- Serine/threonine-protein kinase HRK1
- Protein MSN5
- Protein YRO2
- Protein YGP1
- ATP-dependent permease PDR12
- Probable transporter AQR1
- Zinc finger protein MSN2
Sequence:
MVLINGIKYACERCIRGHRVTTCNHTDQPLMMIKPKGRPSTTCDYCKQLRKNKNANPEGVCTCGRLEKKKLAQKAKEEARAKAKEKQRKQCTCGTDEVCKYHAQKRHLRKSPSSSQKKGRSISRSQPMFERVLSSTSLDSNMLSGHGALSDTSSILTSTFLDSEPGVGKISKDYHHVPSLASISSLQSSQSLDQNFSIPQSPPLSSMSFNFLTGNINETNQNHSNHQHSKSGNNWQDSSVSLPAKADSRLNMMDKNNSVGLDLLGHSKRISPISNSRVGEVSVPLEEYIPSDIDGVGRVTDKSSLVYDWPFDESIERNFSTTATAATGESKFDINDNCNRINSKSYSKTNSMNGNGMNNSNNNNINSNGNDKNNNNSSRQEHQGNGLFDMFTDSSSISTLSRANLLLQEKIGSQENSVKQENYSKNPQLRHQLTSRSRSFIHHPANEYLKNTFGNSHSNDIGKGVEVLSLTPSFMDIPEKERETERSPSSNYITDRPFTRKPRSSSIDVNHRYPPMAPTTVATSPGALNNAVASNLDDQLSLTSLNSQPSSIANMMMDPSNLAEQSSIHSVPQSINSPRMPKTGSRQDKNIHTKKEERNPLNNIHDLSQLENVPDEMNQMFSPPLKSMNRPDAIRENSSSSNFIIQGNSMISTPSGRNDLPDTSPMSSIQTASPPSQLLTDQGFADLDNFMSSL
Protein: DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153) (P14607)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. {ECO:0000250}.
Interaction partners:
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDENGGPYSSSLGNEEGESKTFTTLDPASLAWLTEEPGPAEVTSSSQSPRSPDSSQSCMAQEEEEDQGRTRKRKQSGQCPARGTGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRPGSDRPHVNLQQV
Protein: Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (p160 ROCK-1) (I3LFH3)
Organism: Sus scrofa (Pig)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cell projection, bleb {ECO:0000256|ARBA:ARBA00043945}. Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395}.
Interaction partners:
Sequence:
MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLSAANPNDNRASSNVDKSLQENLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTLSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLAQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSITQLESLNRELQERNRILENSKSQTDKDYYQLQAVLEAERRDRGRDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKDAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFESDNLKGLQKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHIVSRLEETNSMLTKDIDLLRKENEELTDKMRKAEEEYKLKKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPVDSACIPYLFIFYSYLL
Protein: ATP-dependent DNA helicase (EC 5.6.2.4) (Q7YZ98)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU364117}.
Interaction partners:
Sequence:
MAHESAVHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDLLQTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQPVAQFSTPSFRKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYCRTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTERAIKQFEKITEFCERTTCRHKLFSDFFGDPTPDCSGQCDVCKRPKKAEKALEIFHRLCMDDAFKSHISLQDCADLYEGEF