wanglab/gogpt-training-data huggingface dataset:
Protein: Nicotianamine aminotransferase B (EC 2.6.1.80) (Q9ST03)
Organism: Hordeum vulgare (Barley)
Function: Involved in biosynthesis of mugineic acid family phytosiderophores.
Interaction partners:
Sequence:
MATVRQSDGVAANGLAVAAAANGKSNGHGVAAAVNGKSNGHGVDADANGKSNGHGVAADANGKSNGHAEATANGHGEATANGKTNGHRESNGHAEAADANGESNEHAEDSAANGESNGHAAAAAEEEEAVEWNFAGAKDGVLAATGANMSIRAIRYKISASVQEKGPRPVLPLAHGDPSVFPAFRTAVEAEDAVAAAVRTGQFNCYPAGVGLPAARSAVAEHLSQGVPYMLSADDVFLTAGGTQAIEVIIPVLAQTAGANILLPRPGYPNYEARAAFNRLEVRHFDLIPDKGWEIDIDSLESIADKNTTAMVIINPNNPCGSVYSYDHLSKVAEVAKRLGILVIADEVYGKLVLGSAPFIPMGVFGHITPVLSIGSLSKSWIVPGWRLGWVAVYDPRKILQETKISTSITNYLNVSTDPATFIQAALPQILENTKEDFFKAIIGLLKESSEICYKQIKENKYITCPHKPEGSMFVMVKLNLHLLEEIDDDIDFCCKLAKEESVILCPGSVLGMANWVRITFACVPSSLQDGLGRIKSFCQRNKKRNSSDDC
Protein: Probable histone H2AXa (HTA5) (O04848)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H4
- Histone H2B.11
- Histone H2B.10
- Histone H2B.7
- Histone H2B.6
- Lysine-specific demethylase ELF6
- Histone H2B.4
- Histone H2B.1
- Zinc ion binding / DNA binding protein
- PHD finger family protein / SWIB complex BAF60b domain-containing protein / GYF domain-containing protein
Sequence:
MSTGAGSGTTKGGRGKPKATKSVSRSSKAGLQFPVGRIARFLKSGKYAERVGAGAPVYLSAVLEYLAAEVLELAGNAARDNKKTRIVPRHIQLAVRNDEELSKLLGSVTIANGGVLPNIHQTLLPSKVGKNKGDIGSASQEF
Protein: Solute carrier family 25 member 32 (Mitochondrial FAD transporter) (Q6IZB5)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Transports folate across the inner membranes of mitochondria. Can also transport FAD across the mitochondrial inner membrane (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:17279620, ECO:0000269|PubMed:21768094}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MTGQGQPAAGSAAWSTVFRHVRYENLVAGVSGGVLSNLALHPLDLVKIRFAVSDGLEVRPKYKGILHCLTTIWKVEGLRGLYQGVTPNVWGAGLSWGLYFFFYNAIKSYKTEGRAEQLEPLEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYGGVVNPSQRQYKGMFDALVKIYKYEGVRGLYKGFVPGLFGTSHGALQFMAYELLKLEYNKHINRLPEAQLSTPEYISVAALSKIFAVAATYPYQVVRARLQDQHVSYGGVMDVIVKTWRKEGIGGFYKGIAPNLIRVTPACCITFVVYENVSHFLCGLREKKVS
Protein: Uncharacterized protein YOR032W-A (Q8TGS1)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MRRALFIAGQTYLWLNLTHLLLIFSWSSTMAFSQSRRLLTPTVPCPTLLGIDFLILVLRHFDEIFI
Protein: Clathrin heavy chain linker domain-containing protein 1 (Q8NHS4)
Organism: Homo sapiens (Human)
Interaction partners:
- Cyclin-G-associated kinase
- Auxilin
Sequence:
MSVHQIRKHAVLPPIICRSDKEFLESVQRYIITETERLGCSEEGPADEYYIIYRNVFDKVIEHITAYKSILTSIKKEYDAFIETIKKDRRTTFCLHGKLKGLAAEPTALVYYRKRTIQLEAKMRIIESNSSKIQSQIDHIKQCRAEYDTKEVKYCTFSKDPSKPIPGMTLQESMNLDALTKYMKHLEDKYAEIKQAMLIKYVPAQRKADLDEEMIVLLKRRDVAENLNKKLQFCHQRLQIISQALSSWVKSDMSSPFQDFVEQIQKTKYLQGDQGIVEELMEDDPRRAKEAEIMLHYIERFNELISLGEYEKAACYAANSPRRILRNIGTMNTFKAVGKIRGKPLPLLLFFEALFITSHAFPCPVDAALTLEGIKCGLSEKRLDLVTNWVTQERLTFSEEAGDVICDYGEQDTYNKAKCLALAQIVYSECGLHKKAILCLCKQGQTHRVMEYIQQLKDFTTDDLLQLLMSCPQVELIQCLTKELNEKQPSLSFGLAILHLFSADMKKVGIKLLQEINKGGIDAVESLMINDSFCSIEKWQEVANICSQNGFDKLSNDITSILRSQAAVTEISEEDDAVNLMEHVFW
Protein: Permease for AmpC beta-lactamase expression AmpG (Q9X3S5)
Organism: Pseudomonas aeruginosa
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MTQQSWREALVAYKSPASLALLLLGFAAGLPTMLVFNTLSVWLREAGVARDTIGFASWLGLVYAFKWVWSPMLDQWRLPFVGRLGRRRSWLVFSQVLIALGLLGMALCNPQSHLPWLIGLALLVAFASATQDIAIDAYRLEIAEDSRQAALAACYMTGYRAAILLASAGALILAEWFGSTSLNYSQSAWGLTYALFALLILPGLVTSLLIREPAVDVPIHVNPSRFDFNHQLLSVLLLLILLISLPAMITALLDRAWPRAGLYALLMGICLSPWGRQQIRPVRELLATVRRPLLVAARGKEVPLFDFVHQAVSVMVLIILLVTVTAMCRAYYSGAWPRGTLFLLIAASCLSAPGRLLMAPVLTPITEFVQRYRWQALLLLGLISTYRLSDTVMGVMAGVFYIDMGFSKEVIASVSKVFGVLMTLIGAAAGGVLIARFSILSILFIGGAASAATNLLFAMLAQLGPLHAEALPSHDVISLVMALEPHVLMLVMTITLDNFSGGLAASAFVAYLSSLTNLKFSATQYAMLSSTMLLLPRFIGGYSGTMVESLGYEHFFYVTAVMGIPTLLLIGWLWLRRAPSSEAPAPGHQNAEQH
Protein: E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZNRF4) (Sperizin) (Zinc/RING finger protein 4) (Q9DAH2)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (By similarity). Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (By similarity). Could have a role in spermatogenesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8WWF5}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MARFAWTRVAPVALVTFWLVLSLSPTDAQVNLSSVDFLDLPALLGVPVDPKRARGYLLVARPADACHAIEGPWPDNHSLDPLVLVRPLGCSWEQTGRRAQRAGATAASVGPEAPGQLREFEDLEVTVRCDQPARVLLPHAEPCPDPECHPVVVASWALARALALAASTLFVLRQLWPWVRGLGSRGTAVKTQTCQKAQVRTFTRLSDLCAICLDDYEEGERLKILPCAHAYHCRCIDPWFSRAAQRSCPLCKQSVASTHDGSTDGSVGGEEPPLPGHRPPIWAIQARLRSRRLELLARTVPCRRCSSTTSLGVAENVAQSEATSELS
Protein: CDK-activating kinase assembly factor MAT1 (Q8I3Y3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Cyclin 1
- DNA 5'-3' helicase
- General transcription factor IIH subunit 4
- General transcription factor IIH subunit
- DNA 3'-5' helicase
- RNA polymerase II transcription factor B subunit 4, putative
- Cyclin-dependent kinase 2 homolog
- BSD domain-containing protein
- Transcription initiation factor IIE subunit alpha, putative
- DNA-directed RNA polymerase II 16 kDa subunit, putative
Sequence:
MDEYKCISCFEDIYVNNEKKLYFFDICKHKICGECLENHLNKLNKQYCPLCKVSVTKKNVSLFDIEERIYANQKNVRSKLTEIFNKRRHNFENTPLYNNYLEKVEDMIYVLTNECDEKKRKIIEAYIKKYEKDNYKLIEENNALIYQNERKKIHEIVKEEGNLYEIIKHRPIINKVHNETYVHSLIKENPKFFDEVKVANIVEVQPQPLNPAYKNDTDIPLRKYFSQDELYQADYAGGYDTNVVLKRCDIEFNKTIYYNI
Protein: NADPH:adrenodoxin oxidoreductase, mitochondrial (EC 1.18.1.6) (A0A0C4DGN7)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|PIRNR:PIRNR000362}.
Interaction partners:
Sequence:
MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVVGSGPAGFYTAQHLLKHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHSGRCAFWGNVEVGRDVTVPELQEAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGWYNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLEALLLCQRTDITKAALGVLRQSRVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQALLSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH
Protein: Max-interacting protein 1 (Max interactor 1) (P50540)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. Isoform Short, which lacks a segment, has a much stronger suppressive potential and associates with a SIN3 homologous protein.
Subcellular location: Nucleus.
Interaction partners:
- Protein max
- Cell division cycle protein 20 homolog
- Cell division cycle protein 27 homolog
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Anaphase-promoting complex subunit 4
- Paired amphipathic helix protein Sin3b
- Paired amphipathic helix protein Sin3a
- Myc proto-oncogene protein
Sequence:
MERVRMINVQRLLEAAEFLERRERECEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKRRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEADSVSTTSISDLDDHSSLQSVGSDEGYSSASVKLSFAS
Protein: Endoplasmic reticulum transmembrane protein (Q59UQ1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367026}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367026}.
Interaction partners:
Sequence:
MSLQMSLVFCTLIGQMITLLVLVLPLPYVVRQKIVDLTFVLQKSQNFRVGIVFSIILMSLQLLDCIQRLNKYADAETNPHFPGIDYDRLASKFYSQRNLYLSGAVLYLQVAIGTVVTIVRKMVLKEKLYREANIKPATDDEATEIEKLKHLIELKQQDIDTFKKQVQGLQKAYNSLTPEEKKNKNE
Protein: Taste receptor type 2 member 45 (T2R45) (G-protein coupled receptor 59) (P59539)
Organism: Homo sapiens (Human)
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MITFLPIIFSILVVVTFVIGNFANGFIALVNSTEWVKRQKISFADQIVTALAVSRVGLLWVLLLNWYSTVLNPAFCSVELRTTAYNIWAVTGHFSNWPATSLSIFYLLKIANFSNLIFLRLKRRVKSVILVVLLGPLLFLACHLFVVNMNQIVWTKEYEGNMTWKIKLRRAMYLSDTTVTMLANLVPFTVTLISFLLLVCSLCKHLKKMQLHGKGSQDPSTKVHIKVLQTVISFFLLRAIYFVSVIISVWSFKNLENKPVFMFCQAIGFSCSSAHPFILIWGNKKLKQTYLSVLWQMRY
Protein: Golgi-associated RAB2 interactor protein 1A (Q6NXP2)
Organism: Homo sapiens (Human)
Function: RAB2B effector protein required for accurate acrosome formation and normal male fertility.
Subcellular location: Golgi apparatus {ECO:0000250|UniProtKB:B2RXB0}.
Interaction partners:
- Ras-related protein Rab-2B
- Ras-related protein Rab-2A
Sequence:
MSKIRGLPPEVREPGPGVELGVENGLLCQLIHSPEFNLFSNSVVFESNFIQTHVPEADFQVTKPGNWRDVCEGSATVILGVTSSVPSLPLPNVLLMANVTWPQGPFTTWSTPGDAPVINLSRLLPLKYVELRIYDRLQRILRVRTVTEKIYYLKLHEKHPEIVFQFWVRLVKILQKGLSITTKDPRIKFTHCLVPKMPTNSTETTPENSLLSSPQPSEPLVLLAAEQTSGSFSQLSGKPQLTADRNNDTAIEIDNCSSYKIPSPVASPINLNIPMRAALSHSLWEQEDWNEHLLQVHIASYLGEHFLGA
Protein: CUB-like domain-containing protein (H2KYG0)
Organism: Caenorhabditis elegans
Interaction partners:
- DUF4362 domain-containing protein
- Uncharacterized protein
- DUF19 domain-containing protein
- DUF148 domain-containing protein
- DUF19 domain-containing protein
- FIP
- C-type lectin domain-containing protein
Sequence:
MITFSVFCIALLSTTAAALNCSQIPDSYIYAGNVFWYPNNSSNYVTIPPNFNCNYIIKAPITSSELLHGYVVLWNLMKGVNDYIIVTDSLGAKQTLKSRSDSYLTYDVFPGKEMSIQVVTKSVNMGSQFNFKVAYSKVKVGPTTAMKTGGLMNFVNLEYIRGSDPQLPNAVMIRGNEPISVSLATSRYMYPTDLLYNTFVIDGDFWNQTAVYRLLSLEGTAPLVTTGNDVTIVTFFNETYDACAVVLNPKSEADNFSYLTSQASVNGEIDKISFAPLDQRQAVEVVAVQNTKIIMDSLVFDTNVGPWCIAKVVSGPPNNSSQLLLDLSKAQGMMPYVFEMQYFTVIAEECSFSFTVTSNNL
Protein: GPI-anchored wall transfer protein 1 (EC 2.3.-.-) (Meiotically up-regulated gene 59 protein) (Q9UTL4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor (By similarity). Has a role in meiosis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
- GPI mannosyltransferase 1
Sequence:
MSYKLEKEAFVSNLTGSSSIETCGLLLIGIACNVLWVNMTARNILPKGNLGFLVEFFIFCLIPLFVIYVSSKVGVFTLCIASFLPSFVLHVISPINWDVLRRKPGCCLTKKNENTFDRRIAGVTFYRSQMMLVTVTCILAVDFTLFPRRYAKVETWGTSLMDLGVGSFMFSSGTVAGRKNDIKKPNAFKNVLWNSFILLILGFARMFLTKSINYQEHVSEYGMHWNFFFTLGFMALGVFFFRRSLKKVSYFNLATFITLLHHCLLVLTPFQKWALSAPRTNILAQNREGIASLPGYIAIYFYGMYTGSVVLADRPLMYTRAESWKRFQRLLFPLCILLVLYLVSNFLSVGVSRRLANTPYVANVAFINMFFLTIYILIDAYLFPSSVPYGSRVPKLLEDANNNGLLVFLIANVLTGVVNLSFDTLHSSNAKGLTIMTMYLFIICYMAHWLAQHGIRFRL
Protein: Cellulose synthase-like protein B3 (AtCslB3) (EC 2.4.1.-) (Q8RX83)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein DETOXIFICATION 13
- Probable pectinesterase/pectinesterase inhibitor 59
- Probable pectinesterase/pectinesterase inhibitor 60
- Endo-1,4-beta-xylanase 4
- Protein DETOXIFICATION 15
- Pectin lyase-like superfamily protein
- Pectin lyase-like superfamily protein
- Probable pectinesterase/pectinesterase inhibitor 25
- Glucomannan 4-beta-mannosyltransferase 7
- Glycoside hydrolase family 28 protein / polygalacturonase
Sequence:
MADSSSSLPPLCEKISYKNYFLRVVDLTILGFLFSLLLYRILLMNQNNSVWVVAFLCESFFSFIWLLITSIKWSPASYKSYPERLDERVHDLPSVDMFVTTADPVREPPILVANTLLSLLAVNYPANKLACYVSDDGCSPLTYFSLKEASKFAKIWVPFCKKYNIKVRAPFRYFLNPPAATESSEFSKDWEITKREYEKLSRRVEDATGDSHWLDAEDDFEDFSNTKPNDHSTIVKVVWENKGGVGVENEVPHFVYISREKRPNYLHHYKAGAMNFLVRVSGLMTNAPYMLNVDCDMYANEADVVRQAMCIFLQKSMNSNHCAFVQFPQEFYDSNADELTVLQSYLGRGIAGIQGPTYAGSGCFHTRRVMYGLSIDDLEDDGSLSSLATRKYLAEENLAREFGNSNEMVTSVVEALQRKPNPQNTLANSLEAAQEVGHCHFEYQTSWGKTIGWLYESTAEDANTSIGIHSRGWTSSYISPKPPAFLGAMPPGGPEAMLQQRRWATGLLEVLFNKQSPLIGMFCRKIRFRQSLAYLYIFTWGLRSIPELIYCLLPAYCLLHNAALFPKGVYLGIVVTLVGMHCLYSLWEFMSLGFSVQSWFASQSFWRIKTTCSWLFSIPDIILKLLGISKTVFIVTKKTMPKTMSGSGSEKSQREVDCPNQDSGKFEFDGSLYFLPGTFILLVNLAALAGCSVGLQRHRGGGSGLAEACGCILVVILFLPFLKGMFEKGKYGIPWSTLSKAAFLAVLFVVFSVGN
Protein: Non-motile and phage-resistance protein (EC 2.7.13.3) (P37894)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator PleD, leading to its activation.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Response regulator PleD
- Polar differentiation response regulator
- Sensory/regulatory protein RpfC
- histidine kinase
- Histidine protein kinase DivJ
- histidine kinase
- CpdR
- Cell cycle transcriptional regulator CtrA
- Sensor histidine kinase/response regulator
- histidine kinase
Sequence:
MGRHGGPAAAGPTAPSAVRAKAVNAPSQVFVRIAILAALLLLAVYTAFGVHRLQREAMAQPGGAPLAAKADLIAGRVDANLAAQRAGLSAAADLLKRDPGATMDAAETTLRAAGGEAAAVAVVSEAGVVAVAGRDDGADWKAAALAAGASGRTNWVGSVGETGRLYVATTTSLDRARAFVIASGDASRLVADPEKGESGALALPDGKLIAARGRGVQGAGALREAFALSIEDLGDGPAAVRGQAADGALLDVAVRPVAQGALLAVAAAPTRSVANLDRQVMEGAFSLLVPLGVGIALALLLMIQSRKAEVAHREFIDSERRFRLAVEAARCGIWEWDLNGDQVYLSDVTGAMFGWGGGGVVSGQDLLERISIDHRERVRQALANAAMYGAFDVSFRVPASEQGARSLWIDARGQGFGKPGSEGHARIIGVALDVTEERIAQARAQAAENRLRDAIESVSEAFVLWDRQGRLLMCNRNYRSVFSLEPKILKPGAARAEVNRFAALAIKQDHPAPDGAKGVREAEMMDGRWIQISERRTAEGGLVMTAADITAIKTQEEARRRNEEQLQNAVAGLERSQEQLAELARKYETEKVKAESANKAKSEFLANMSHELRTPLNAINGFSEIMMNEMFGPLGDQRYKGYSQDIHSSGQHLLALINDILDMSKIEAGKMNLKFESMHLEDVAEDAVRLVRNRAEAAGLKLDIDFPQLPEIEADYRAVKQVLLNLLSNAIKFTPRAGSVTVRAEVRRDPFGDLIKVSVTDTGIGIAKEDLARLAKPFEQVESQFSKTTQGTGLGLALTKSLITMHDGVLEMHSTPGEGTTVSFTLPVRHSDQKITRDFVAA
Protein: Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (Core 1 O-glycan T-synthase) (T-syn) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1) (Q9JJ06)
Organism: Mus musculus (Mouse)
Function: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9JJ05}; Single-pass type II membrane protein.
Interaction partners:
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
- C1GALT1-specific chaperone 1
- Polypeptide N-acetylgalactosaminyltransferase 2
- Polypeptide N-acetylgalactosaminyltransferase 1
Sequence:
MASKSWLNFLVFLCGSAIGFFLCSQLLSILLREEAAIQPNMLHNDPHARHSDDNGHSHLKGQMNFNADSSQHKDENIDVAENLYQKVKILCWVMTSPQNLEKKAKHVKATWAQRCNKVLFMSSEENQDFPTVGLKTKEGREQLYWKTIKAFQYVHDHYLEDADWFMKADDDTYVIVDNLRWLLSKYNPEQPIYFGRRFKPYVKQGYMSGGAGYVLSKEALRRFVNAFKTEKCTHSSSIEDLALGRCMEIINVEAGDSRDTIGKETFHPFVPEHHLIKGYLPKTFWYWNYNYYPPIEGPGCCSDIAVSFHYVDGTTMYELEYLVYHLRPYGYLYRYQPALPENILKEINQVNRKEDTKIKLGNP
Protein: Receptor-type guanylate cyclase gcy-8 (EC 4.6.1.2) (Q9GYQ4)
Organism: Caenorhabditis elegans
Function: Guanylate cyclase involved in the production of the second messenger cGMP. Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3. cGMP levels antagonize the actin cytoskeleton regulator wsp-1.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:16415369}. Note=Localizes exclusively to the sensory ending, known as cilium, in AFD neurons. {ECO:0000269|PubMed:16415369}.
Interaction partners:
- Probable 3',5'-cyclic phosphodiesterase pde-2
- Bis
- Inosine triphosphate pyrophosphatase
- Probable 3',5'-cyclic phosphodiesterase pde-5
- Cyclic nucleotide-gated channel
- Cyclic nucleotide-binding domain-containing protein
- Probable 3',5'-cyclic phosphodiesterase pde-1
- Homeobox protein ttx-1
- G-protein coupled receptors family 1 profile domain-containing protein
- GTP cyclohydrolase 1
Sequence:
MRTKKAFLLLTFNVLIYLAACQETERILANNGTEDNEITTSKGVSPNTNPLFLSNSTAGLYDSKGRIRLTIGHIGAIGALRNDVKILEVSHKALQAEGILDDDLDVEIISQTGCGESYEGVAVAADMYHLQKVKAFIGPYCNAEMDAVARMAAFWNIPIIGYMAASNNLADKNAYPTLARISLRTTNSIAEATCAMLRHYGWNKVAIITNTGILAYDRVLSFEEVFHQRGINVVKKIMFDEFADSKAMIASGLLNDIKNSARIVVCLFSNTRESSREFLTAANTQGMNVNEYGYVFPWLQDGGKDASPWTGADGSMLQKVKDQYANAIIIDDVNSFDNTIVGPFIERIKDVGLTEADVDIANIYGYLYLFDALKLYAIAARKVLNETGKAENLLNGRMMWQNMRKLKFVGMVGASGIASGQVSMDDRAERAPLYRGFFVSPNSDSVLPMVHMEPTMLDNCDGIANKSGCYEIVVTDIMRDFWPSVDRKMPKDEPDCGYRNERCDYTLIIIGAALILLFIVAAVSAFFAQKILEKRALDKLPFRIYRDDLQFIDEEQLKSMLSLGSTRTKMSNMNYGSRNHAIVGTNTHAIYHKYVQRRPIVFNRADKTLIQLMKAAVHDNINPFLGMVWNEREEMLLVWKFCSRGTLQDIIYNESIQLDTKFHGAFIRDILAGLEYLHASQIGYHGSLTPWSCLIDRNWMIKLTDYGIADPLERWEKSQSISRDGLTSDDDKSQATQATSILYESPEMLKNREKNRVRRVDQDWMRQTQTRRQLGDVYAFGLVMYEIIFRALPFPEGTNQSELVEWLRDGSKVVKPTIPQNKVLNMDLSALIQDCWNTTPEMRPSLRRIKLNVETYLNIKGSLVDQMTRMMEQYANNLEKLVAERTGMLEEANQRADRLLSQLLPAYVANELKLGRPVPPKTFTSSTVLFSDIVGFTEMCQNASPLEVVAVLNGIFDGFDQFIARKDAYKVETIGDAYMVVSGVPEENGHRHINEIASIALDVHKFLSEFIVPHKRDTKVQCRLGFHTGPVAAAVVGLNAPRYCLFGDTVNMASRMESNSEPGKTQISETAKNLLLKEYPDYICEQRGEIPIKGKGLCMTYWLMGTKSEGSGRSGAYLAPSMKSAGTGFTGMLGNSANDYSLNLKNPTGLQR
Protein: Peroxiredoxin 2 family protein/glutaredoxin (Q7DDK4)
Organism: Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
Interaction partners:
- Peptide methionine sulfoxide reductase MsrA/MsrB
- Glutathione peroxidase homolog
- Glutathione synthetase
- Glutathione hydrolase proenzyme
- 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase
- Ribonucleoside-diphosphate reductase
- Thioredoxin
- Thioredoxin-related protein
- thioredoxin-dependent peroxiredoxin
- Superoxide dismutase
Sequence:
MALQDRTGQKVPSVVFRTRVGDTWKDVSTDDLFKGKKVVVFSLPGAFTPTCSSSHLPRYNELFGAFKENGVDAIYCVSVNDTFVMNAWAAEEESDNIYMIPDGNGEFTEGMGMLVGKEDLGFGKRSWRYSMLVNDGVVEKMFIEPEEPGDPFKVSDADTMLQFVAPDWKAQESVAIFTKPGCQFCAKAKQALQDKGLSYEEIVLGKDATVTSVRAITGKMTAPQVFIGGKYIGGSEDLEAYLAKN
Protein: Protein DBF4 homolog A (MuDBF4) (Q9QZ41)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role DNA in replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Cell division cycle 7-related protein kinase
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM7
- Origin recognition complex subunit 6
- Origin recognition complex subunit 4
- Origin recognition complex subunit 2
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM2
Sequence:
MNLETMRIHSKAPLPGGIQDRNEKNRPSLKSLKADNRLEKSKYKPLWGKIFYLDLPSITICEKLQKDIKELGGRVEEFLSKDISYFVSNKKEAKYAQTLGRVSPVPSPESAYTAETTSPHPSHDGSSFKSQDRVCLSRGKLLAEKAVKDHDFIPANSILSNALSWGVKILHIDDIRYYIEQKKKALSALKKSSASGKDAGKKAGPGIQKTRTGRLKKPFLKVEDVNRCYRPFYLQLPSLPCINYFLQKPCSPFDIEKSSSVQKQAQPKLRINMDGDKCGTPVQLQLKEKRKKGYCECCLQKYEDLETHLLSEKHRNFAQSNQYQVVDDIVSQLVFDFVEYGRDTPQKKRIRYSVGSLSSVSANVLKNTAPKEKPLLEPNFQKDVGESSGHLLKPNSQYEETQKPEEKHGFASEPTTYSSAGLKGCDRKPVSMFNASEPDPEQEYAQLPLRDSTPEHQVTEGRNDGEQRVDPAPGVSQSCGQVSHLSTESNLPQPQLAADITQLSAKDLQEKGFHVVIGHASDLVALNTSKEQLTMKARTPPCSPQEPHECDTENMENLPCGKIQRKVRMLLGQQKANAEPSAELDKKRTEYLPAHEDRTCGSPVQSLLDLFQTSEEKSEFLGFTGYTENSGICDVLDIWEEENSSTLLSTFFSSPSTSAFVGF
Protein: Laccase-8 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 8) (Diphenol oxidase 8) (Urishiol oxidase 8) (Q9LFD2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lignin degradation and detoxification of lignin-derived products (By similarity). Involved in the flowering time inhibition.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Phenylalanine ammonia-lyase 1
- Phenylalanine ammonia-lyase 2
- Phenylalanine ammonia-lyase 4
- Cinnamoyl-CoA reductase 2
- Phenylalanine ammonia-lyase 3
- Cinnamoyl-CoA reductase 1
- Probable caffeoyl-CoA O-methyltransferase At4g26220
- Trans-cinnamate 4-monooxygenase
- Putative caffeoyl-CoA O-methyltransferase At1g67980
- Cytochrome P450 84A1
Sequence:
MPRLHHYLSNQAFLVLLLFSSIASAAVVEHVLHIQDVVVKPLCKEQIIPAANGSLPGPTINVREGDTLVVNVINNSTYNVTIHWHGVFQLKSVWMDGANMITQCPIQPGYNFTYQFDITGQEGTLLWHAHVVNLRATLHGALVIRPRSGRPYPFPKPYKEVPIVFQQWWDTDVRLLQLRPAPVSDAYLINGLAGDSYPCSENRMFNLKVVQGKTYLLRIVNAALNTHLFFKIANHNVTVVAVDAVYSTPYLTDVMILTPGQTVDALLTADQAIGKYYMATLPYISAIGIPTPDIKPTRGLIVYQGATSSSSPAEPLMPVPNDMSTAHRFTSNITSLVGGPHWTPVPRHVDEKMFITMGLGLDPCPAGTKCIGPLGQRYAGSLNNRTFMIPERISMQEAYFYNISGIYTDDFPNQPPLKFDYTKFEQRTNNDMKMMFPERKTSVKKIRFNSTVEIVLQNTAIISPESHPMHLHGFNFYVLGYGFGNYDPIRDARKLNLFNPQMHNTVGVPPGGWVVLRFIANNPGVWLFHCHMDAHLPYGIMSAFIVQNGPTPETSLPSPPSNLPQCTRDPTIYDSRTTNIDLSY