wanglab/gogpt-training-data huggingface dataset:
Protein: SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22) (Q7Z422)
Organism: Homo sapiens (Human)
Interaction partners:
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L1
- Serine-threonine kinase receptor-associated protein
Sequence:
MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSSPNSTSRPTLPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR
Protein: Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) (Q99P96)
Organism: Rattus norvegicus (Rat)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8C2B3}. Cytoplasm {ECO:0000250|UniProtKB:Q8C2B3}. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation. {ECO:0000250|UniProtKB:Q8C2B3}.
Interaction partners:
- Histone acetyltransferase KAT5
- Forkhead box P3
- Nuclear receptor corepressor 1
- NAD-dependent protein deacetylase sirtuin-1
- Hepatocyte nuclear factor 3-alpha
- Hypoxia-inducible factor 1-alpha
- Nuclear receptor corepressor 2
- Histone H2A.Z
- Histone deacetylase 1
- H2B.L histone variant 1
Sequence:
TPGSQPQPMDLRVGQRPTVEPPPEPALLTLQHPQRLHRHLFLAGLQQQQRSAEPMRLSMDPPLPELQGGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPSSPSIPYRTLEPLDTEGAARSVLSSFLPPVPSLPTEPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPALGSEADG
Protein: Aralin B chain (P83573)
Organism: Aralia elata (Japanese angelica tree)
Function: Lectin specific for galactose (Gal) and its derivatives. Induces apoptosis. Has cytotoxic activity against several human cancer cell lines. Is less cytotoxic to normal human cells.
Interaction partners:
Sequence:
ANPICPKIPNPTIRISGRNDLCVDVK
Protein: Small ribosomal subunit protein uS7 (30S ribosomal protein S7) (P38526)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
Interaction partners:
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS5
- Conserved hypothetical protein
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein uS8
- Trigger factor
- Large ribosomal subunit protein uL4
- Elongation factor G
- Small ribosomal subunit protein uS9
Sequence:
MRRRRAEKRQIPPDPVFGDVLVAKLINRVMWDGKKTIAQKIVYGAFDIIREKTKKDPLEVFRQAVENVKPVLEVRPRRVGGATYQVPIEVQEPRRTSLALRWIVEAARAKKGRPMKEKLAEEIIAAYNNTGTAIKKKEDTHRMAEANRAFAHYRW
Protein: WW domain-containing adapter protein with coiled-coil homolog (Protein wacky) (Q9VX88)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-118' (By similarity). Regulates the cell-cycle checkpoint activation in response to DNA damage (By similarity). Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates Tor activity. Promotes, in an energy-dependent manner, the assembly of the TTT complex and the RUVBL complex composed of pont and rept into the TTT-RUVBL complex (By similarity). This leads to dimerization of the mTORC1 complex and its subsequent activation (By similarity). May negatively regulate the ubiquitin proteasome pathway (By similarity). Required for habituation, a form of non-associative learning.
Subcellular location: Nucleus {ECO:0000269|PubMed:26812014}. Lysosome {ECO:0000269|PubMed:26812014}.
Interaction partners:
- BcDNA.LD23634
- Cell division cycle 5, isoform A
- GEO08385p1
- U1 small nuclear ribonucleoprotein 70 kDa
- E3 ubiquitin-protein ligase Bre1
- LD45152p
- Histone H2B
- Splicing factor 3B subunit 3
- Pre-mRNA-processing factor 39
- Small nuclear ribonucleoprotein F
Sequence:
MVMHARKPQRMNDGYFEKHTSHTSYQSSKYSSSKRDYERDRSSNYRDRDLSPGAGGGGGGGSAGGGGGGSGNGGGPLNNGNSYRSQSPDIDSPSSRSHDLRDRSDHRGGGGGNGRGGSGERYSFMQKMRDRDRDVYKKDKYSDKRDRRGNDRDSESSYRTNHDRDRRGGGGSGGGSGKLCSSRENDKRSGSDDRDRDRDRDLRDLRDKRDRGSDRDRDMYKKDKYADKRERSDRGERTARYGDWSEHVSSSGKMYYYNCKTEISQWEKPKEWVDRERNLPRDQHREKDYRDKDRDRDRDDRFSRSTYKHSNSSRDNSRLRWNYDNDGGPPSHRRRLDGRHNDNADMDISGDSTPTSEASYSLSGTPTTHGGGPGGGGPGGGGGSNSDQPMGNALPRLSSHPTANSSASVATGTGATGGLHYGSGTGGGPVTGATMLPTMSGMLNSNSSNSAGGSSSNASSSSLRNSVVGHIGSTSGTTVPTLGSQDPHQHHLNSNAPLPPGAKGKDQALLMRQKMHLGLGVLDVQSHHGVNSVGSVSDGTNHAYNSVNNSVSGSLRDNSVNSPLYMHHSMSPSLNFTKSPIPTIVGHTNNMSIAYTCNPPFGLKATLDGGVMVANASPATPGGNASSGSSGANSSQSIVPGMGPVCGISVITSMGSNSGTLCEGPPTPTQELDLSGSALEQQQLAAAAAAATASSLQLQAAQQAQQQRKLDGTSSATLSSLQSCVSSSGQAANLRGPEISPKLAKYFRADLIAHVTNWHAEVLERQAQKCCEDTHLFGDITCTRICAELKCARSLVRSTEINATLQEQKIMYLRHQIRRIEESKTQNAFMSDDT
Protein: Nitrogen assimilation regulatory protein nac (Nitrogen assimilation control protein) (Q47005)
Organism: Escherichia coli (strain K12)
Function: Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity).
Interaction partners:
- Nitrogen regulatory protein GlnK
- Ammonium transporter AmtB
- HTH-type transcriptional regulator cbl
- Sensory histidine kinase/phosphatase NtrB)
- DNA-binding transcriptional regulator NtrC)
- HTH-type transcriptional regulator HdfR
- Uncharacterized protein YbdD
- HTH-type transcriptional regulator DmlR
- Uncharacterized HTH-type transcriptional regulator YcaN
Sequence:
MNFRRLKYFVKIVDIGSLTQAAEVLHIAQPALSQQVATLEGELNQQLLIRTKRGVTPTDAGKILYTHARAILRQCEQAQLAVHNVGQALSGQVSIGFAPGTAASSITMPLLQAVRAEFPEIVIYLHENSGAVLNEKLINHQLDMAVIYEHSPVAGVSSQALLKEDLFLVGTQDCPGQSVDVNAIAQMNLFLPSDYSAIRLRVDEAFSLRRLTAKVIGEIESIATLTAAIASGMGVAVLPESAARSLCGAVNGWMSRITTPSMSLSLSLNLPARANLSPQAQAVKELLMSVISSPVMEKRQWQLVS
Protein: Sterol regulatory element-binding protein 2 (Sterol regulatory element-binding transcription factor 2) (Q90WR7)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004653}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MESGELGTEGMETLTELGDELTLGDIDEMLQFVSNQAGDFPDLFSDPLCGTFQGGGGGGGSGTGVGALDAARPYGQAPQPFPPPAASPQLQSVPVKAPPAPQRPAPLLQPRPQLQPQLQQQTVMIAPTFSSAPQTRIIQQPVLYQNAATSFQVLQPQVQSLVTSPQVQPVTIQQQVQAVPAPRVLTQAAGGTIQALAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGNPVMAAVQNPALTALTTPIQTTAPQTLVGSNGTILTTMPVMMGQEKVPIKQVPGGVKQPDPPKEGERRTTHNIIEKRYRSSINDKIIELKDLIMGTDAKMHKSGVLRKAIDYIKYLQQGNHKLRQENMVLKLANQKNKLLKGIDLSSLVDNDADLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCALTFLCLSFNPLTSLLDARGSPESDSLTRHGSGRNMLTIESDTGGWFGWMMPTLILXLVNGVXVL
Protein: Sodium/hydrogen exchanger (Q8MQP4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSIRTEQDYDSATPALAQQMNLARRACWRIKSYSSESLFKTYASVITDTSANEIDAEAPPPPRDKTKTRIEPQIAPAKRNSSCTSSDWRGMFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPRPKPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSKLTMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGRWAPPTIYTTCPSLTNLDNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVNYKMQMNFRRMFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNAEECQQNPNEINVVGPSDDWDDGLTFTAKSSLAEHPIPEEDRNLSRESDGERRVATPTATESQLPWKRQGDECTDAVQQNEFPAWASNKEYLAYNSPSATFLGGINKPKQPKSVIGLFRRESSSSKAGSVGVGSTGAMDSAASGSEKKKK
Protein: PX domain containing serine/threonine kinase like (A0A0C4DG95)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAFMEKPPAGKVLLDDTVPLTAAIEASQSLQSHTIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQQVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKIQGLELQQIKTYGRQILEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTISRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKKRKILARKKSKRSALENSEEHSAKYSNSNNSGSGASSPLTSPSSPTPPSTSAALGLSKRCKERDICITSTSSTSTTTSSSLASCEHRGTCPALVSGCEWHEPRGLAQLHPEFPKRNFEESQNL
Protein: Drosulfakinins [Cleaved into: Drosulfakinin-0 (DSK-0); Drosulfakinin-1 (Drosulfakinin I) (DSK-I); Drosulfakinin-2 (Drosulfakinin II) (DSK-II)] (P09040)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in diverse biological roles including regulating aspects of gut function, satiety and food ingestion, hyperactivity, and aggression. Regulates gut muscle contraction in adults but not in larvae. Functions downstream of TfAP-2 and twz in octopamine signaling pathways to modulate feeding and male aggression. Inhibits consummatory behavior in adults and functions as part of a negative feedback loop with TfAP-2 and twz to prevent overeating; TfAP-2 and twz regulate octopamine signaling to initiate feeding, then octopamine activates expression of Dsk in insulin-producing cells (IPCs) to inhibit feeding.
Subcellular location: Secreted.
Interaction partners:
- Cholecystokinin-like receptor at 17D1
- Short neuropeptide F
- Gastrin/cholecystokinin type B receptor
- Neuropeptide F
- Protein hugin
- Insulin-like peptide 2
Sequence:
MGPRSCTHFATLFMPLWALAFCFLVVLPIPAQTTSLQNAKDDRRLQELESKIGGEIDQPIANLVGPSFSLFGDRRNQKTMSFGRRVPLISRPIIPIELDLLMDNDDERTKAKRFDDYGHMRFGKRGGDDQFDDYGHMRFGR
Protein: Vacuolar protein sorting-associated protein 16 (Vacuolar morphogenesis protein 9) (Vacuolar protein-targeting protein 16) (Q03308)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. Required for growth at elevated temperatures. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
Subcellular location: Cytoplasm. Vacuole.
Interaction partners:
- Vacuolar morphogenesis protein 7
- Vacuolar morphogenesis protein 6
- Vacuolar protein sorting-associated protein 3
- Vacuolar membrane protein PEP3
- Vacuolar protein sorting-associated protein 41
- E3 ubiquitin-protein ligase PEP5
- Syntaxin VAM3
- Vacuolar protein sorting-associated protein 8
- Ypt/Rab-type GTPase YPT7
- Vacuolar protein sorting-associated protein 33
Sequence:
MKNPSFDWERLKDVFYRSRAIGELKWPTQYEEFKCALSLTVIAVEIQDFIQVYNYFGQLLGKINLQRIHEDIIKFEFDKDEKLILVTKSSIKIVKGWSPLTIESVPLQDPTIDTIWDYHNGIMLLAKSRDIYKLNGNEWELLYENKDKKYNLLTKNHWSCNDDSIILLDVDHVYQVSTSNGALLKLITDSSWHKVTISSRGFICLYNMKDNKLQIFRDPARILMEHNLDSTPDDICWCGNDTVACSFEDEIKLYGPDGLYVTFWYPFTVTNLRAEVDGLKVITTEKIYFLSRVQPQTSNIFRIGSTEPGAMLVDSFSLLEDHAPKAIEILKNFVLEKGVLDCIAAAIDEFEPKLQKMLLNAASYGKASLQYKSFDASIFVNACNTIKLLNCFRSFGIFLTVEEYRCISLKGVIDRLLKYHRYYECIQICKLANERFLLGYVFTEWAKDKIKGSPDMEDDELLDKIKSRLSVIDMTDTLQMVAVAKVAYLEGRFQLSRNLALLEKNEEARIEQLYNLDDDSIALKECIKVQNYSLTISLLIALSKKLTNSQLTKLLIIDMFNNPLYLYYMRMDKAYLYDFYRQTDRFIDLAHVLLQQGKEQQSLHSFLPQIKDLYSQVQNSEVVNNTIEQLQRQEKLWIYQESLGKRFAISFTNMTLDQTLSKLIETGQDKQVKEIVKKFKISEKKLYHLKCKTLVEAKKFDELLQFAQSRKSPIGYMPFYTYLKSRGHMDKASPYVNMIPGLSYQEKKKLYVECRGFRDAIQLAGKEKDIPGLKEIYNIIPPNEPELKALANETMSRI
Protein: Ketol-acid reductoisomerase, mitochondrial (EC 1.1.1.86) (Acetohydroxy-acid reductoisomerase) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Q6FXG6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Mitochondrion {ECO:0000256|PIRNR:PIRNR000119}.
Interaction partners:
- Acetolactate synthase
- dihydroxy-acid dehydratase
- Candida glabrata strain CBS138 chromosome H complete sequence
- T-complex protein 1 subunit gamma
- 3-isopropylmalate dehydratase
- Branched-chain-amino-acid aminotransferase
Sequence:
MIRAQASRLICNSRVITSKRTFALAARAASMRPAASLMAQKSIKPIVATRGIKQINFGGTVETVYERADWPREKLLNYFANDTFALIGYGSQGYGQGLNLRDNGLNVIIGVRKDGASWKAAIEDGWVPGENLFEVEEAVKKGTYVMNLLSDAAQSETWNSLKPLLTKGKTLYFSHGFSPVFKDLTHVEPPKDIDVILVAPKGSGRTVRSLFKEGRGINSSYAVWNDVSGKAHEKAQALAVAVGSGYVYQTTFEKEVNSDLYGERGCLMGGIHGMFLAQYEVLRENGHSPSEAFNETVEEATQSLYPLIGKYGMDYMYDACSTTARRGALDWYPIFKDALKPVFQDLYESTKNGSETKRSLEFNSQPDYREKLESELQTIRDMEIWRVGKEVRKLRPENQ
Protein: Phosphoribosyl transferase domain protein (O51130)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
- Nucleoside 2-deoxyribosyltransferase superfamily
- Nucleoside diphosphate kinase
- Sugar ABC transporter, ATP-binding protein
- Uncharacterized protein BB_0381
- thymidine kinase
Sequence:
MKKYVSYEEIRINGFKLAYKIYKDGFIPDIMYVSLRGGAYLGNIISEFFKFVKVDKPLLYAAVVARSYDIFNEQKKIMIDGWTYDPKYLRAGDKVLFVDDIFDTGRTIVYLRNEVLKKGIESENVKIAVYDYKDHGFVDYIPDYYVNKYSNQEELNTWIHYGNHELTGLNESEYKNSFKYIDDELNEILKFLAKNKS
Protein: Pro-thyrotropin-releasing hormone (Pro-TRH) (Prothyroliberin) [Cleaved into: Thyrotropin-releasing hormone (TRH) (Protirelin) (TSH-releasing factor) (Thyroliberin) (Thyrotropin-releasing factor) (TRF)] (P01150)
Organism: Rattus norvegicus (Rat)
Function: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
Subcellular location: Secreted.
Interaction partners:
- Thyrotropin-releasing hormone receptor
- Thyrotropin-releasing hormone receptor 2
- Prolactin
- Prolactin-6A1
- Corticoliberin
- Oxytocin-neurophysin 1
- Pro-neuropeptide Y
- Somatostatin
- Pro-opiomelanocortin
- Thyrotropin subunit beta
Sequence:
MPGPWLLLALALIFTLTGIPESCALPEAAQEEGAVTPDLPGLENVQVRPERRFLWKDLQRVRGDLGAALDSWITKRQHPGKREEEEKDIEAEERGDLGEGGAWRLHKRQHPGRRANQDKYSWADEEDSDWMPRSWLPDFFLDSWFSDVPQVKRQHPGRRSFPWMESDVTKRQHPGRRFIDPELQRSWEEKEGEGVLMPEKRQHPGKRALGHPCGPQGTCGQTGLLQLLGDLSRGQETLVKQSPQVEPWDKEPLEE
Protein: Uncharacterized transcriptional regulatory protein C1F7.11c (Q09922)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Histone H4
- Set1 complex component ash2
- Set1 complex component swd1
- Histone H2B-alpha
- Inner kinetochore subunit mis15
- Inner kinetochore subunit mal2
- 5'-AMP-activated protein kinase subunit beta
- Histone H3-like centromeric protein cnp1
- Histone H3.1/H3.2
- Histone H3.3
Sequence:
MSASGKKPGTKGTKRHRKITSCRECHRLKLKCDRVWPCENCKKRGIPNLCPNGILVSVSDKLIKLLLSRIDTLQNCVKSVSPNHESLIVSSDDQKIIDDIYEKFGEKPAEDTKDENRSQPIHDPDHPTLEDVAQMLGKLKVGSHGYFNYYGASSSRSCIPQQDPNSEEEDTFMQRPFLYPASSYNSALHWSHRIPNILNPSTLCDMLPVPQFAVRLMGLYFDNVGWSSHIIHRPSFEEACLNLYSAAPDRTNPQPQFLSLTYMVFCLGTLFTSPVLVRNRYSLAHEFFLRAQLCFDISVSGFTPSLDSVVAVMLMAQYSYFCDRLERTNFAWNCIGLAIRLAVAMGLHRDGEVFELSAFQLHMRRLIWSELLFFDRMLSMSLGRPFAISNDQTNVHEPSNVCDIQISSQSNCIPDPSYERTEASFTIFKAKLSKVIASVLDRAFRFTPPSYSEVEALTEQFKVLENELPDYMRISRDTPNLPPMVIIEQYSAKFLIQQALLYLHRPWFVRAATRKEEREHYKSSFNLCTSVSHELIHNLYSLMCLVPVEPLRWWVFRFHSLNAGIIQAAYALCFPNTDYALTAYNDLQYICRIFEHLKGGFMFSNKDYDFLIQLKSKVFNRFQLSSQGLTPEDLTEDVPFLHFNVPSSRPNSKSPDDSSMRAEKAAQLDGLGLSSDDLNTAQSENLPIYEQENPLLFDSLSWHVPKDDTRNDKSPLVPTWNADMMFEEEQKPIVPIDLSSMQDDQVSSLTTNEEFDPLSSFQASHSGSNFWTNMMNEMGIPK
Protein: PF06257 family protein (A0A0H2US72)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MSDAFTDVAKMKKIKEEIKAHEGQVVEMTLENGRKRQKNRLGKLIEVYPSLFIVEFGDVEGDKQVNVYVESFTYSDILTEKNLIHYLD
Protein: Geminin coiled-coil domain-containing protein 1 (Q3URY2)
Organism: Mus musculus (Mouse)
Function: Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Note=Associates with chromatin during pre-replication complex (pre-RC) formation. {ECO:0000250}.
Interaction partners:
- Transcription factor E2F5
- Multicilin
- Transcription factor E2F4
- Cyclin-O
- Forkhead box protein J1
Sequence:
MNSILPCQDQYFVGGQSYNCPYSTTTSESGVDVSKETWVSFWAAGLLDNTELQQAPQVLESPSELSFPVLDSCSWEEAQLSSQLYRNKQLQDTLLQKEEELARLHEENNHLRQYLNSTLVKRLEEKAKKLLSSDEFSKVFGKLRKEKRKPKEHRHSPAEIPQFKTAKRNLSTEFSNCEEQPGPHVDPWVLQTLGLKDLNTIDDTLPANYSATTSHPRAVPSISSLFVHDANGYANVPRDLHLDYVGQGTHGSHTTSIHQEDCHSFPRLSNPPVRVQTLPYHTADVSPNKTEMAFSTSLSPHCNVKTHSFHQGQAFVRRDEEGGWKFTWVPKQT
Protein: Mitochondrial import inner membrane translocase subunit tim50 (O13636)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit tim17
- Mitochondrial import inner membrane translocase subunit tim23
- Mitochondrial import inner membrane translocase subunit tim21
- Mitochondrial import inner membrane translocase subunit tim44
- Mitochondrial import inner membrane translocase subunit tim14
- Mitochondrial import inner membrane translocase subunit tim16
- Probable mitochondrial import receptor subunit tom40
- Protein mgr2
- GrpE protein homolog
- Probable mitochondrial import receptor subunit tom70
Sequence:
MLNRSLLFRNLRLARPRPFLPLVGKRFVTEKSQSQEEKDTSKITENAKEEVKRDTSSLAKESLKLLDLNGLNDESYTGDPGKGPEYTSSTMLKREKQARYAFWGFLGLTGGGLLYYGRRYGPDEKELEKQYPAAGYSPSDWWNRVKARTNNFFSYYQEPAFEKLLPDPLPEPYNRPYTLVLSLDDLLIHSEWTRQHGWRTAKRPGLDYFLGYLSMYYEVVIFTRQYLATAKPIIDKIDPYHVSISAVLTRESSKYEKGKVIKDLSYLNRDLSRVIMIDTNPESWSKQPDNAIAMAPWTGNPKDKELVGLIPLLEFIAIMDIKDVRPVLKSYQGKNIPLEYARREEKLRTKLIEDWNEKKKKGSSFLFGGRSVSEEPPKLIIDIQRERQKAAYAEFKKYIDENGPKMLEEEKAREAEQKTSIFNLLFHPEEVQQQQLEQMQQQQFSPETNASK
Protein: ANKH inorganic pyrophosphate transport regulator (F1SRN1)
Organism: Sus scrofa (Pig)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Alkaline phosphodiesterase I
Sequence:
MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRTKAVLCMVVAGAVAAVFHTLIAYSDLGYYIINKLHHVDESVGNKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYKNIHDIIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKAVSTSNTVTAAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVVPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLITSLVVLPYLGYVVHGATLGVGSLLAGFVGESTMVAIAACYVYRKQKKKMENESAVEGEDSAMTDIPPAEEGTDVVEMREETE
Protein: Cytochrome P450 71A23 (EC 1.14.-.-) (Q9STL0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- At5g19440
Sequence:
MILFLCLIILFIITILFFKKHKTVNKIINFPSPPRLPLIGNLHQLSQHPHRSLCYLSHRYGPLMLLHFGSVPVIVASTAEAARDVLKTHDRVFASRPRSKIFEKLLYKSRNMASAPYGEYWRQMKSVSVLHLLSNKMVRSFQDVRQEEITLMMETIRKSSSKPVNLSKILSSLTNDVICRVALGRKYGVGTDFKELIDRLMRQLGTFTIGSYVPWLAWTDWVSGLEARLEKTANDFDKLLERIVQDHEDGDGDKTDFVDVLLAAQRDKSFGFDIDRLSIKAIVLDAFVGGTDTSSTLVEWEMTELLRHPTCLKKLQEEVRTICKGKSSVSEDDIQGMEYLKAVVKEALRLHPPVPLMVPHQSTQDVRLRDNHIPAGTQVIVNLWAVGREAATWGPDANEFRPERHLESPSDFRGQDFELIPFGAGRRMCPGISFAVVLNEVVLANLVHGFDWQSIDDETDVAESIGSVIRRMHPLYVIPSSTT
Protein: Protein Aster-A (GRAM domain-containing protein 1A) (Q8VEF1)
Organism: Mus musculus (Mouse)
Function: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain. At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER. May play a role in tumor progression. Plays a role in autophagy regulation and is required for biogenesis of the autophagosome. This function in autophagy requires its cholesterol-transfer activity (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q96CP6}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:30220461). Localizes to distinct EPCS than GRAMD2A and ESYT2/3 (By similarity). {ECO:0000250|UniProtKB:Q96CP6, ECO:0000269|PubMed:30220461}.
Interaction partners:
Sequence:
MFDTTPHSGRSSPSSSPSLRKRLQLLPPIRPPPASEPEPGTMVEKGSDSSSEKSGVSGTLSTQSLGSRNFIRNSKKMQSWYSMLCPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVCPLQLNGLGSPKEVGDVIALSDISPSGAADHSQEPSPVGSRRGRVTPNLSRASSDADHGAEEDKEEQTDGLDASSSQTVTPVAEPLSSEPTPPDGPTSSLGPLDLLSREELLTDTSNSSSSTGEEGDLAALLPDLSGRLLINSVFHMGAERLQQMLFSDSPFLQGFLQQRKFTDVTLSPWSSDSKCHQRRVLTYTIPISNQLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLDRELAKAEKLSLEEGGKDTRGLLSGLRRRKRPLSWRGHRDGPQHPDPDPCTQTSMHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVLIVLIALNALLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKHFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVPDPPLDTQPQPDDSFP