wanglab/gogpt-training-data huggingface dataset:
Protein: Protein unc-33 (Inactive dihydropyrimidinase unc-33) (Uncoordinated protein 33) (Q01630)
Organism: Caenorhabditis elegans
Function: During neurogenesis, plays an essential role in axonal guidance and outgrowth by regulating the polarization of both microtubule and actin cytoskeletons. Establishes the asymmetry of axonal and dendrite microtubules and the polarized sorting of neuronal proteins. This is achieved in part by regulating the localization of kinesin-like protein unc-104. In neurons without a distal microtubule-organizing center (MTOC), also controls the organization of microtubules in dendrites. During the dorso-ventral axonal guidance and outgrowth of VD neurons, required downstream of Rac GTPases ced-10 and mig-2 to inhibit growth cone filopodial protrusion mediated by the unc-6/netrin receptor unc-40-unc-5. Specifically, regulates growth cone filopodial protrusion polarity, and thus migration, by promoting F-actin polarization and by restricting plus-end microtubule accumulation in the growth cone. Probably downstream of mab-20/Sema2a and mab-20 receptor plx-2, regulates the guidance of DD/VD neuron axons by modulating fln-1 interaction with F-actin which results in the remodeling of the actin cytoskeleton. In hermaphrodites, involved in sex myoblast (SM) migration by regulating the gonad-dependent repulsion of SMs.
Subcellular location: Cell projection, axon {ECO:0000269|PubMed:16236031}. Cell projection, dendrite {ECO:0000269|PubMed:16236031}.; SUBCELLULAR LOCATION: [Isoform a]: Cell projection, axon {ECO:0000269|PubMed:22101643}.
Interaction partners:
- Multifunctional protein pyr-1
- Probable Golgi transport protein 1
- AO66 ankyrin
- Dihydropyrimidine dehydrogenase [NADP
- Dihydroorotate dehydrogenase
- Carrier protein
- Trifunctional purine biosynthetic protein adenosine-3
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Cytochrome-b5 reductase
- NADH-cytochrome b5 reductase
Sequence:
MFPFLAPIRSANHVEQQGTKYYVEITFLADSPYSRAPSSTGTEKSVIPTLRNLDDLETVSNKSRSSEGVNKLGSRPNSRSSAIVKKTSVSSLPTSARSEGKSSPIPVKDAIPAPARHKNKGLEMSSAMMELFGGGGSTSPAPSKRENPADAPSDRVVSNAKLSQPGPEWFEGFEQMDMTDIELPPDPNCPAEKVLRGEKSTPDFDSDWQEAKEDVLDPQSYPKSFNPAESLPGPDIGAGVDDEEEPEAEAQEMEEPQYESKVDEKDDDDNGSSSSKKGHPSEDGDSTRNGETPTDRRNSGAIEETADGESSAQSAAEKKNSGDDGNGGGGEMSILLVKNAQIVNDDAIFVADILIEDGIIQNVAPNLEAPEGAEVLDAAGKLALPAGIDVYTQVTDSSVDDLSTGCKSAIAGGTGTIVEVVRPRGAESVVSAVKRVKNQLEKSGISCHVALSVAITDFCEQEMSELVKNEGINSFVLDGVSLTDDKLLELFEHVKRLGALIRVVPENKSIVAMLEKKMLKLGVTGPEGFPQSRPESLEADRVSGVCVLGNLASCPISIVQVSSADSLAAIEKARASGALAHAEIASAAVTADGSALFSQDLRFASAHLTDVPLRRGAPDRMIGALSTQPLVVCTSGHRPVNSATRVAAKDFAIAQKGSTGAEERMAVVWERAVRSGRIDAMRFVAVTSTNAAKMFNMYPKKGRIAVGADADLVIWDASGKRVLESSRAQSSQENSMYDGLTVHSVVTATIVGGKIAYQNGEVREAPVAGGFLRLSPNSPYLFSMVGQRDKFANVERVEREASSQQQKPQQNGHHKNSGDFDRNRTKVMESSIDFGGSAANRPRNPPGGRTTGFW
Protein: Guanine nucleotide-binding protein subunit alpha-15 (G alpha-15) (G-protein subunit alpha-15) (O88302)
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Interaction partners:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- B2 bradykinin receptor
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- Guanine nucleotide-binding protein G
Sequence:
MARSLTWGCCPWCLTEEEKTAARIDQEINKILLEQKKQERGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEDRRAFRLLVYQNIFVSMQAMIEAMDRLQIPFSRPDSKQHASLVMTQDPYKVSSFEKPYAVAMQYLWRDAGIRACYERRREFHLLDSAVYYLSHLERIAEDDYIPTAQDVLRSRMPTTGINEYCFSVQKTKLRIVDAGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENSQENRMKESLALFSTILELPWFKSTSVILFLNKTDILEDKIHTSHLASYFPSFQGPRRDAEAAKRFILDMYARVYASCAEPHDGGRKGSRARRLFAHFTCATDTHSVRSVFKDVRDSVLARYLDEINLL
Protein: SUN domain-containing protein 4 (AtSUN4) (F4I8I0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Encodes a member of the mid-SUN subfamily of SUN-domain proteins that is localized to both the nuclear envelope and the ER. It is involved in early seed development and nuclear morphology. [TAIR].
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:25217773}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25217773}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- SUN domain-containing protein 1
- SUN domain-containing protein 2
- TIR domain-containing protein
- Protein KAKU4
- WPP domain-interacting tail-anchored protein 2
- Protein CROWDED NUCLEI 1
- Nuclear envelope-associated protein 1
- Nuclear envelope-associated protein 3
- Protein CROWDED NUCLEI 4
- Mitotic-spindle organizing protein 1B
Sequence:
MQRSRRALLVRRRVSETTSNGRNRFYKVSLSLVFLIWGLVFLSTLWISHVDGDKGRSLVDSVEKGEPDDERADETAESVDATSLESTSVHSNPGLSSDVDIAAAGESKGSETILKQLEVDNTIVIVGNVTESKDNVPMKQSEINNNTVPGNDTETTGSKLDQLSRAVPLGLDEFKSRASNSRDKSLSGQVTGVIHRMEPGGKEYNYAAASKGAKVLSSNKEAKGASSIICRDKDKYLRNPCSTEGKFVVIELSEETLVNTIKIANFEHYSSNLKDFEILGTLVYPTDTWVHLGNFTALNMKHEQNFTFADPKWVRYLKLNLLSHYGSEFYCTLSLLEVYGVDAVERMLEDLISIQDKNILKLQEGDTEQKEKKTMQAKESFESDEDKSKQKEKEQEASPENAVVKDEVSLEKRKLPDPVEEIKHQPGSRMPGDTVLKILMQKIRSLDVSLSVLESYLEERSLKYGMIFKEMDLEASKREKEVETMRLEVEGMKEREENTKKEAMEMRKWRMRVETELEKAENEKEKVKERLEQVLERLEWMEKKGVVVFTICVGFGTIAVVAVVFGMGIVRAEKQGGLAWLLLLISSTFVMFILSL
Protein: Bazooka, isoform C (X2JFU8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKVTVCFGDVRILVPCGSGELLVRDLVKEATRRYIKAAGKPDSWVTVTHLQTQSGILDPDDCVRDVADDREQILAHFDDPGPDPGVPQGGGDGASGSSSVGTGSPDIFRDPTNTEAPTCPRDLSTPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLFLDKAGGQLSPQWEEDDDPSHQLKEQLLHQQQPHAANGGSSSGNHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLAVGNQGPPINTVPGTPSTSSNFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAALDARETGTYQRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAAAEAEARDQLGDLGPSLGMKKSSSLESLQTMVQELQMSDEPRGHQALRAPRGRGREDSLRAAVVSEPDASKPRKTWLLEDGDHEGGFASQRNGPFQSSLNDGKHGCKSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALAALERNGKPPAYQPPPPLPAPNGVGSNGIHQNDIFNHRYQHYANYEDLHQQHQQHQISGGDSTTSISETLSESTLECMRQQVIRQRIKVEAESRRHQHYHSQRSARSQDVSMHSTSSGSQPGSLAQPQAQSNGVRPMSSYYEYETVQQQRVGSIKHSHSSSATSSSSSPINVPHWKAAAMNGYSPASLNSSARSRGPFVTQVTIREQSSGGIPAHLLQQHQQQQLQQQQPTYQTVQKMSGPSQYGSAAGSQPHASKV
Protein: Presenilin-1 (PS-1) (Zf-PS1) (EC 3.4.23.-) (Q9W6T7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49768}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P49768}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P49768}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P49768}. Cytoplasmic granule {ECO:0000250|UniProtKB:P49768}. Cell membrane {ECO:0000250|UniProtKB:P49768}. Cell projection, axon {ECO:0000250|UniProtKB:Q4JIM4}. Synapse {ECO:0000250|UniProtKB:Q4JIM4}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P49768}.
Interaction partners:
- Gamma-secretase subunit PEN-2
- Gamma-secretase subunit Aph-1b
- Catenin beta-1
- Zgc:114200.
- Ncstrn_small domain-containing protein.
- Catenin, beta 2.
- Amyloid beta
- Neurogenic locus notch homolog protein 1
- Presenilin-2
- cAMP-dependent protein kinase
Sequence:
MADLVQNAANNVLNDGMDTSRHTSSTAAPPSRNEVELNGQPPTAPPPQVVTDSEEDEDEELTLKYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTQKDGQQLIYTPFREDTETVGQRALHSMLNAIIMISVIVVMTLVLVVLYKYRCYKVIQAWLFFSNLLLLFFFSLIYLGEVFKTYNVAMDYFTLALIIWNFGVVGMICIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAAISVYDLLAVLCPKGPLRILVETAQERNEAIFPALIYSSTMVWLFNMADSAETRNNSSHPVPQQENQVVAMAPTAQAEDDGGFTPAWVDHQQHQLGPMQSTEESRRQIQEMPSARPPPPADDDEERGVKLGLGDFIFYSMLVGKASATASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDNLVRPFMDQLAVHQFYI
Protein: Alkaline/neutral invertase E, chloroplastic (A/N-INVE) (EC 3.2.1.26) (Q9FK88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Chloroplastic invertase that cleaves sucrose into glucose and fructose and is associated with the development of the photosynthetic apparatus and the assimilation of nitrogen in seedlings to control the sucrose to hexose ratio. Participates in the carbon flux between the cytosol and plastids in leaves.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18034262}.
Interaction partners:
- Sucrose synthase 2
- Sucrose synthase 1
- Sucrose synthase 3
- Sucrose synthase 6
- Sucrose synthase 4
- Sucrose synthase 5
- AT1G06500 protein
Sequence:
MAASETVLRVPLGSVSQSCYLASFFVNSTPNLSFKPVSRNRKTVRCTNSHEVSSVPKHSFHSSNSVLKGKKFVSTICKCQKHDVEESIRSTLLPSDGLSSELKSDLDEMPLPVNGSVSSNGNAQSVGTKSIEDEAWDLLRQSVVFYCGSPIGTIAANDPNSTSVLNYDQVFIRDFIPSGIAFLLKGEYDIVRNFILYTLQLQSWEKTMDCHSPGQGLMPCSFKVKTVPLDGDDSMTEEVLDPDFGEAAIGRVAPVDSGLWWIILLRAYGKCTGDLSVQERVDVQTGIKMILKLCLADGFDMFPTLLVTDGSCMIDRRMGIHGHPLEIQALFYSALVCAREMLTPEDGSADLIRALNNRLVALNFHIREYYWLDLKKINEIYRYQTEEYSYDAVNKFNIYPDQIPSWLVDFMPNRGGYLIGNLQPAHMDFRFFTLGNLWSIVSSLASNDQSHAILDFIEAKWAELVADMPLKICYPAMEGEEWRIITGSDPKNTPWSYHNGGAWPTLLWQLTVASIKMGRPEIAEKAVELAERRISLDKWPEYYDTKRARFIGKQARLYQTWSIAGYLVAKLLLANPAAAKFLTSEEDSDLRNAFSCMLSANPRRTRGPKKAQQPFIV
Protein: DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) (Q9UBC3)
Organism: Homo sapiens (Human)
Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:11735126, ECO:0000269|PubMed:12145218}.
Interaction partners:
- DNA
- DNA
- Histone-lysine N-methyltransferase EZH2
- Histone deacetylase 1
- DNA
- Histone H3.1
- Histone H3.2
- Histone deacetylase 2
- Histone H3-7
- Histone H3.1t
Sequence:
MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
Protein: Protein disulfide-isomerase A6 homolog (EC 5.3.4.1) (Calcium-binding protein 1) (DmCaBP1) (Q9V438)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds to both apoptotic cells and phagocytes and promotes Drpr-dependent phagocytosis of apoptotic cells.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:22158613}. Cell surface {ECO:0000269|PubMed:22158613}. Note=Relocates from the endoplasmic reticulum to the cell surface during apoptosis. {ECO:0000269|PubMed:22158613}.
Interaction partners:
- Heat shock protein 83
- Protein disulfide-isomerase
- Calreticulin
- Endoplasmic reticulum chaperone BiP
- Ero1-like protein
- Thioredoxin domain-containing protein 5 homolog
- Protein windbeutel
- LD25575p
- IP08350p
- DnaJ homolog shv
Sequence:
MRQLASILLLAFVVGSVSAFYSPSDGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALKGVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSGSSSGDDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELKGKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEIINESTFETACEGKPLCVVSVLPHILDCDAKCRNKFLDTLRTLGEKFKQKQWGWAWAEGGQQLALEESLEVGGFGYPAMAVVNFKKMKFSVLKGSFSKDGINEFLRDISYGRGHTAPVRGAKKPAIVSVDPWDGKDGQLPTEEDIDLSDIDLDKDEL
Protein: Glutathione S transferase O1 (EC 1.8.5.1, EC 2.5.1.18) (Glutathione S-transferase omega class) (RE55814p) (Q9VSL6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glutathione S transferase T2
- Glutathione S transferase T1
- Glutathione S transferase E7
- Glutathione S-transferase D1
- Glutathione S transferase O2, isoform A
- Glutathione S transferase E4
- Glutathione S transferase E8, isoform A
- Glutathione S transferase E12, isoform A
- GST-containing FLYWCH zinc-finger protein
- Glutathione peroxidase
Sequence:
MSNTQHLTIGSPKPVFPDDGILKLYSMRFCPYAHRVHLVLDAKKIPYHAIYINLRDKPEWFSLVSSSTKVPALELVKEQGNPVLIESLIICDYLDEKYPEVPLYPKDLLKKAQEKILIERFGQFINAFYYLLLHDNPEQLVDTDHYAGLVVYEEELKRRCTKFFGGDSPGMLDYMMWPWCERFDSLKYTFEQKFELSPERFPTLIKWRDLMIQDRAVKCFYLDGQTHAKYMNSRRSGQADYNMLYNEAKRVKLG
Protein: Fructose-1,6-bisphosphatase, cytosolic (FBPase) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase) (Protein FRUCTOSE INSENSITIVE 1) (Q9MA79)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the first irreversible reaction from fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate and plays an important regulatory role in sucrose biosynthesis and metabolism (Probable). Its activity is essential to regulate starch levels. Functions in fructose-mediated signaling independently of its catalytic activity in sugar metabolism. May act downstream of ABA2/GIN1, which is involved in abscisic acid (ABA) synthesis to regulate autotrophic transition and modulate early seedling establishment after seed germination.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21253566}. Nucleus {ECO:0000269|PubMed:21253566}.
Interaction partners:
- Glucose-6-phosphate isomerase, cytosolic
- Transketolase-1, chloroplastic
- Transketolase-2, chloroplastic
- Glucose-6-phosphate isomerase 1, chloroplastic
- transaldolase
- Hexokinase-1
- Aldolase-type TIM barrel family protein
- Hexokinase-3
- Hexokinase-like 1 protein
- Probable hexokinase-like 2 protein
Sequence:
MDHAADAHRTDLMTITRFVLNEQSKYPESRGDFTILLSHIVLGCKFVCSAVNKAGLAKLIGLAGETNIQGEEQKKLDVLSNDVFVNALVSSGRTSVLVSEEDEEATFVEPSKRGKYCVVFDPLDGSSNIDCGVSIGTIFGIYTLDHTDEPTTADVLKPGNEMVAAGYCMYGSSCMLVLSTGTGVHGFTLDPSLGEFILTHPDIKIPNKGNIYSVNEGNAQNWDGPTTKYVEKCKFPKDGSPAKSLRYVGSMVADVHRTLLYGGIFLYPADKKSPNGKLRVLYEVFPMSFLMEQAGGQAFTGKKRALDLVPEKIHERSPIFLGSYDDVEEIKALYAEEEKKN
Protein: Complex III assembly factor LYRM7 (LYR motif-containing protein 7) (Q9DA03)
Organism: Mus musculus (Mouse)
Function: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Interaction partners:
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Tetratricopeptide repeat protein 19, mitochondrial
- UBX domain-containing protein 7
- Iron-sulfur cluster co-chaperone protein HscB
- Mitochondrial chaperone BCS1
- Ubiquinol-cytochrome c reductase complex assembly factor 1
- Succinate dehydrogenase assembly factor 1, mitochondrial
- Ubiquinol-cytochrome-c reductase complex assembly factor 3
- Small ribosomal subunit protein mS35
- Large ribosomal subunit protein mL46
Sequence:
MGQPAKVLQLFKTLHRTRQQVFKNDKRALEAARVKINEEFKKHKNETSPEKIKEMMKLGSDVELLLRTAVIQGIHTDHDTLQLVPRKDLLTENVPYCDAPTQKQ
Protein: GUK-holder, isoform C (Q4AB30)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPFVQRVVQPVNVAQATAASLGHASGRFHCTPGKCRNNNCINKQSPDVEVPNGHGSPTSLTRVLVHQAPEDQPVPPAPAPMKKLKHHVEFLSTSPTRHQSQSLPNSRHPSQQRPALGRIASAPQSPTAGSSKVVSGHEFDSISNITLSNALRQLASLVLIASDIFDDLQRDLQAVGERAGRVQRKIAAVERRVCAYDPKTVTVPESDLLTFAQRKHHFETDKSFQQELFTGETRPLSVRQLYTEAGKELPVATGATATALASLAHSQSLIPSRSISFNGEVLSSDHEVLQLNGSTDTEDHLLCVSDFGNANRKLRTRIDAEIEIRLPAAIEDLRKWTSSEALGDVTVTPDCMHHVDTSVSTSLAIGENGILTPALSPSVLSADAVDALYAQNLSQAADSSRHNHHTQALIPNDINKDVPLNHRLPSPEEQTKQIALKYPAEVISVNTSGKHFQRMCAARKSTSGGYAGGATAGSSSSTSPENAGQTEGNNLDDNVQTVSRRSRSRKVRGKRRNTIAGIDQKEIQDAANGLKRRKGAHTTFAPGPYVKETESALHSAESAAAAIASSQDPSAASGAISSTKSAKLLLLTSGGLISGNRKVANVRPIVAKSPLSRNVSEMATYQATSYQDQKQLLANRTNPFYETIAAPVANLMMPSPSGKSNSSTGSTATSSSSSASGQSGEEGYQRFSNIYEQVQPAPSTQPQEDATATPFQRSAPIYWTLQNRRSQPRPQPAGNVTCRDDLYATPIRRADRLPRPVAAAAATAAEGNRSNISPIVPRNRSGAFLTSTPTRSGEGERDSENTQLPPMKQPSRNWTDDAPERLNTCADRIGQSKTTLMDFKKLLLAKSAKASPVQRKVSAVELLKKPAQATATPPVVKPSGPGQKVASAGSKPTINTSLKLLDLSGSPKTFANRRMLRQGQFGSPSKTFAPKMRGPVNMVAAAAAPPRTDIMSTTIPEANSEEDHSNTSGGSRASSEAGETVPSSFDLKRNFFLQTEENNFMRGELKPSFARSNGAAGGGSTEGVNKYVAAPVANPPLPSFETAL
Protein: Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2) (P58753)
Organism: Homo sapiens (Human)
Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19948740}. Cell membrane {ECO:0000269|PubMed:19948740}. Membrane {ECO:0000269|PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane.
Interaction partners:
- Interleukin-1 receptor-associated kinase 1
- TNF receptor-associated factor 6
- Toll-like receptor 4
- Myeloid differentiation primary response protein MyD88
- Toll-like receptor 2
- Toll-like receptor 6
- Interleukin-1 receptor-associated kinase 4
- Toll-like receptor 1
- Toll-like receptor 9
- Interleukin-1 receptor type 1
Sequence:
MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTSSDASQPTSQDSPLPPSLSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQDLVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQMLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQTLS
Protein: Protein SOSEKI 1 (AtSOK1) (Q9SYJ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: SOSEKI proteins (SOK1-5) locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes, probably by guiding ANGUSTIFOLIA (AN) polarized localization.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30737509}; Peripheral membrane protein {ECO:0000269|PubMed:30737509}; Cytoplasmic side {ECO:0000269|PubMed:30737509}. Note=SOSEKI proteins (SOK1-5) integrate apical-basal and radial organismal axes to localize to polar cell edges in roots, pointing towards the endodermis, mainly to inner apical edges. {ECO:0000269|PubMed:30737509, ECO:0000269|PubMed:32004461}.
Interaction partners:
- Transcription factor PRE3
Sequence:
MESNGGGGEVRRVNLVYFLSRSGHVDHPHLLRVHHLSRNGVFLRDVKKWLADARGDAMPDAFSWSCKRRYKNGYVWQDLLDDDLITPISDNEYVLKGSEILLSSPKEDYPNVEKKAWVTRNGGIDAEEKLQKLKLTSEKIQKESPVFCSQRSTATTSTVTEESTTNEEGFVLKKQDPKTVSGQRDGSTENGSGNDVESGRPSVSSTTSSSSYIKNKSYSSVRASHVLRNLMKCGGLDTNDAVLVPLNKSRSGAFGPAWEDERRYQYHQQHNARKSFEGAWSGIKMKETIEFCKPKVAPSKPSMAPLCSQCGKLFKPEKMHSHMKLCRGMKNSSANNDLMTSNNTVKPRQQRCRNIPGNPLGHQRVLTTTLKE
Protein: Respiration factor 1 (Q05043)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial and nuclear transcriptional activator required for respiratory growth.
Subcellular location: Cytoplasm. Nucleus. Mitochondrion.
Interaction partners:
- Zinc finger protein RME1
- Meiosis-inducing protein 1
Sequence:
MKDLNPEMGKFATTKGPPQDNRGMVDIATLPNFPANRSGTPREEMYLAPNKMETPRILNMNMVPDYLQKENFSPDFSSATVSAKSSPVNVTHDESLPLGTIESNSTKDSKYAVQRQQQQVVDFIENNMQLLSSETLNFRSDIMKTLELPIPKRRDIKGNHLSKLLFAKSPLTINTYCQFYDRRTKRICNQEMIWKDKNSREKHGSRKYQRHLSKVHDVQLTPNNFTEFFDHNSPLFQECYDYQSRLMRDLLVEPDAKFKEKKKKKKGDVNGNHPETGSSLINHQVQQQNVRELQSKIAMNDLIEILIDLNIPFSVLDYQPMRNWLIKYSIISTDTLPDEVYFKTDPGVNELEHNSSNLNNSNSGTPHNHNQNQHTN
Protein: Syndecan (A0A0S2Z4U3)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}.
Interaction partners:
Sequence:
MAIAYLGSSCPSQPPSSLALSLSPTPSDFEQESGIETAMRFSPDVALAVSTTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIRTTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTPETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKEVLVAVIVGGVVGALFAAFLVTLLIYRMKKKDEGSYTLEEPKQASVTYQKPDKQEEFYA
Protein: GLPGLI family protein (G5EBP0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MIILTFLLFCATVVAENSIHIQYFRRPEEYGIFKVIIDGSRQWESYIYMNRSANLREEEIYKLVKPFFEQDPSTRRYESSSITRHLGKQFEYILNRYTIDEIAFENLCSQMKPKFSSIILSTTQTPKKIKWVVEHPSAPFTIPTGFTKNMGRDEYQIEIGGKAKLDDDNFDFEALQNTQKLIIKQPTEFKNGVNGKRLLKFFAPELYMEGTNEIDSDSLKEFGKEWLEGDRIVRNWEIHLYDEKQSENLYFEKNGTTLQLTIENGRFTASTYKTPEGLIYTFTSL
Protein: Carboxypeptidase A inhibitor (P19399)
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Function: Inhibits carboxypeptidase A.
Subcellular location: Secreted.
Interaction partners:
Sequence:
DQVRKCLSDTDCTNGEKCVQKNKICSTIVEIQRCEKEHFTIPCKSNNDCQVWAHEKICNKLPWGL
Protein: Kinesin-like protein (A0A1D8PT88)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Kinesin-like protein
- Tubulin beta chain
- Tubulin alpha chain
- Kinesin-like protein
- Serine/threonine/tyrosine protein kinase
- Kinesin-like protein
- Structural maintenance of chromosomes protein
- Ase1p
- Probable kinetochore protein NUF2
- Probable kinetochore protein NDC80
Sequence:
MSNIQVVVRCRGRNSQEIAAKSPIVVELTNDNYSITEPYITINQGYTRATATTTTNNTTTTNSNNTAGATPNTSASSLDTNSKRTYKFDQIYGSQADQNLIYSQIAHPLLLDFLRGINVTVLAYGQTGTGKTYTMSGMDNNNKLDENSDIAGIIPRLLGELFQNLSSNATSKNDYMVKISYLEIYNEELIDLLSNNNSNNRKLRIHEKTNANKVKSIGIQNLTEYTINNYNQGIKYLKMGLQKKKTSSTNLNETSSRSHTIFSVQLYQKISSSSSSSSENDNEESVYRISKMNLVDLAGSENISRSGSIVKEAGGINQSLLTLGRVINSLNEKKLSHIPYRESKLTHILQDSLGGNTKTTLIATISPAQVNLSETCSTLDYASKAKNIKNAPMIGHDSEIIMKKTLVKNLAQELTLLNMDLIATRNKNGVYLDPENYDQLIQENESLKTGAKEDRLKLESLQAKIETLEFTKLEAKEEIDNLKQQLQSYQSKLQILETKYHKAVGLNQTNQETICELNNKLKQAFEKSSSSAELLVNLLSNHLHTSIGLVNESRNLQQDNKSVDQLTNFQLEFTKNLDEYKQQLETNLQNYQSQVGNIVNEDLTNYISTFQKNFDNLLTFQQEFYNKTFEVIQDFKIINEKLSGFLKDDYLHNIETNLNSQLGNILGENLPILVDNFKKIMTKELKTTMNNVMDKYKTVSNEEISKERENVLKMENSWNSQINCLLPKLETDLNNNNKFHHDCQTNLQKFINNNDICERINKFQQDNNSQLDKINPFDLKPKLTSSINGITNDIQQYHNQMNNNLTKINQELTQIQQFDANTMKISPIKESSRIPITTANMPNNQFKPIKLHRSNTACGGGGATGKSPSPTRIPTLQRSKSNVPEDTSPQDSTTTNNNKKRKILQTMDNLL