wanglab/gogpt-training-data huggingface dataset:
Protein: Presenilin 1 (G3V3Z0)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, growth cone {ECO:0000256|ARBA:ARBA00004624}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004520}.
Interaction partners:
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIM
Protein: Trehalose synthase complex regulatory subunit TPS3 (Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 115 kDa subunit) (P38426)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Alpha,alpha-trehalose-phosphate synthase 56 kDa subunit
- Trehalose-phosphatase
- Trehalose synthase complex regulatory subunit TSL1
- Cytosolic neutral trehalase
- Probable trehalase
- Periplasmic acid trehalase ATH1
- Glycogen [starch] synthase isoform 2
- Glycogen [starch] synthase isoform 1
- UTP--glucose-1-phosphate uridylyltransferase
- Probable UTP--glucose-1-phosphate uridylyltransferase
Sequence:
MTIIVASLFLPYTPQFEADVTNSDTAKLVESSMIKVDCNNQELSNNKQERSSSVTSASSHYIGLPQEAQINGEPLQRANVGSPATGVNYHNEMEMLSSEQFLEELTANATHAANSGIPPANNPVSSGSTAQRPSVEEFFSAPSARVCSPSQEASASSISASRSSAHHNDLSSSLMKNPNLSFDSHPPRVRSSSKSAVITPVSKSVPDVDPAVVDVAKVREEFQQQASLPSMKRVSGSTAGDSSIASSSSNLRYSQQFQDNFIEDTDSEDDIDSDLETDATKKYNVPKFGGYSNNAKLRASLMRNSYELFKHLPWTIVDSDKGNGSLKNAVNIAVAEKTVKEPVSWVGTMGIPTDELPHEVCHKISKKLEQDFSSFPVVTDDITFKGAYKNYAKQILWPTLHYQIPDNPNSKAFEDHSWDYYQKVNQKFSDRIVSVYKPGDTIWIHDYHLMLVPQMVREKLPKAKIGFFLHVSFPSSEVFRCLANRERILEGIIGANFVGFQTKEYKRHFLQTCNRLLAADVSNDEVKYHCNIVSVMYAPIGIDYYHLTSQLRNGSVLEWRQLIKERWRNKKLIVCRDQFDRIRGLQKKMLAYERFLIENPEYIEKVVLIQICIGKSSDPEYERQIMVVVDRINSLSSNISISQPVVFLHQDLDFAQYLALNCEADVFLVDALREGMNLTCHEFIVSSFEKNAPLLLSEFTGSSSVLKEGAILINPWDINHVAQSIKRSLEMSPEEKRRRWKKLFKSVIEHDSDNWITKCFEYINNAWESNQETSTVFNLAPEKFCADYKASKKHLFIFKISEPPTSRMLSLLSELSSNNIVYVLSSFTKNTFESLYNGVLNIGLIAENGAYVRVNGSWYNIVEELDWMKEVAKIFDEKVERLPGSYYKIADSMIRFHTENADDQDRVPTVIGEAITHINTLFDDRDIHAYVHKDIVFVQQTGLALAAAEFLMKFYNSGVSPTDNSRISLSRTSSSMSVGNNKKHFQNQVDFVCVSGSTSPIIEPLFKLVKQEVEKNNLKFGYTILYGSSRSTYAKEHINGVNELFTILHDLTAA
Protein: Replication protein A 32 kDa subunit B (OsRPA32B) (OsRPA32-2) (Replication factor A protein 2B) (Replication protein A 2B) (Q6H7J5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Replication protein A 70 kDa DNA-binding subunit B
- Replication protein A 70 kDa DNA-binding subunit A
- Replication protein A 70 kDa DNA-binding subunit C
- DNA primase large subunit
- Os05g0358200 protein
- Os01g0660500 protein
- ATP-dependent DNA helicase
- DNA polymerase alpha catalytic subunit
- Replication protein A 32 kDa subunit A
- DNA polymerase alpha subunit B
Sequence:
MYGVGVGGGGGGNYDGGGGNASSLFGGGGFMPSQATNAAEGTSGGGGGFPKSRNAQALLPLTVKQIMDASQTNDDKSNFAVNGMEVSTVRLVGRMLNKLDRVTDVSFTLDDGTGRVPVNRWENDSTDTKEMADIQNGDYVIVNGGLKGFQGKRQVVAYSVRRITNFNDVTHHFLHCVHVHLELTRPKSQVNANTATGTPNQTMPRDSMAYNQSPLTNQASTFSAPQNTGTGTNMIDLVLNVFHDPAVMNDDHGVGVDYVSRRLNLPEETVGKIIIDQVDLGHLYATIDDHHYKSTMNG
Protein: Cytadherence high molecular weight protein 1 (Cytadherence accessory protein 1) (Q50365)
Organism: Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae)
Function: Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle (By similarity).
Subcellular location: Cell projection, attachment organelle membrane. Note=Localizes specifically to the attachment membrane.
Interaction partners:
- Cytadherence high molecular weight protein 2
- Cytadherence high molecular weight protein 3
- Adhesin P1
- P30 adhesin
- Uncharacterized protein MG328 homolog
- Chaperone protein DnaK
- Small ribosomal subunit protein uS4
- Phosphomannomutase
- Uncharacterized lipoprotein MPN_199
- Uncharacterized protein MG316 homolog
Sequence:
MKKSKEAVFEDKDYTEENPEQIFGNLYDGKLTVQDGKVKIAYDGDGNGYYIAFNSETGVYYDPYGDTEYDISVLFDANGNSFVFADAPTVEVLAGEQEQTEAEPDYLQYVGNEAYGYYDEAGEWVWSGYFEGDQWISTLPQTEAEEKQFGFEDNIETTPTASEDFGLEADVPAPEVAEPSYEVQPEVAAEPVYDVQPEVAVEPVGETTATVEPQAVEIQPEVVVEPIVESQLEQPVEVQAEMVQPEVAVEPQLEVSLDPIGETAPILEQVEPQAVQTQPEIPAEQSAVELQPEPVAEVQSEMVQPEAAAEPVTEAQQTEPTPVVETIAEITPQVVTEPVVAVVEHQPEAVAEPLPVEPAVAGVSELIPTEQVQPEVVVESTPVAEVQSEMVQPEVAVEPIVEPQPEQPVEVQPEVITTPEVASVLEVQPENPVVEVEQVVEPQPETPVEVQPEPVVETVQEAVAEPTQVVEPQPQAAPQPAVYEWNLTPEAAPVEQPEVIPVTVVESQATATAEPQPAVAPVADMDYVLHLTDTVKNQPQTAPVQPTTPIKIEVAESTPTVTTSPVEPTIAPPLFEIELNNTTSSDLPLVEVVDFKHNQHGAVGTHSFDDFTPPEVGMESKTHCHSNSEVVWRVSEPKTVPVPPAVSSINIQTVNRVVEPTISTPTTPVVESAPAIEIFVDTPPVETKEASSNVDVVQQPVKPLMPVMVEQLRTTELQPTTEINLFANSDINSIIAELKQGRSNPAINFDDIFKMSSYQMVVKKSFVQISDFITNSKTDITNRFLLIKKELQAELTRLIEENEQLKAEFLNAKDLSVYQKDELLRSLSNDFTIAHRPSDSYEQLQKSGELVRNIQKAILENESKIKNIQITLKELKAVYKLCSDTVLNGMAKLDSVLRFNKKEKDPLLLNSMETLSSFETEPQAIIEDLLDFSSSFDKMSNEQLDEFVYQNLDSGLNLDLDGFDHQLSSMNIHGLEPLDPMKLDDFDFETLTPDKTSNLSSILDDELMENGGDFNLDY
Protein: Uncharacterized N-acetyltransferase C550.08 (EC 2.3.1.-) (O59806)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Golgi apparatus {ECO:0000269|PubMed:16823372}. Vacuole {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Isopentenyl-diphosphate delta-isomerase
Sequence:
MAAKRVEAKDYKKAAATLVDAFFDDPVCVYLCHTTNEQQFKKLMTEMFEYIVYAHIIRGLVLEVGDFAGISLWMGPGNNMDDWYSILRSGLWRLKYKLDGEGRKRFFNEFLPILNDTKADVLKERDDHSWYLVYVGVSSKEQGKGYLRKLIEPIFNICDQEGLPIYLESSHLHNRPIYEHFGFVYQQSIYLTRDNQKVPLEIMIREPETESKAEQSAKPKAALSKTVSASIAEKVEGSLAVSSTPVC
Protein: ELAV-like protein (P79736)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MVTIISTMETQVSNGPSGTSLPNGPVISTNGATDDSKTNLIVNYLPQNMTQEEFKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYVDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKDMEQLFSQYGRIITSRILVNQVTGISRGVGFIRFDKRNEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTQLYQTAARRYTGPLHHQTQRFRFSPITIDSMTSLAGVNLTGPTGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTSKQHKA
Protein: CLAVATA3/ESR (CLE)-related protein 16D10 (Esophageal gland cell secretory protein 16) (Q6YKB1)
Organism: Meloidogyne incognita (Southern root-knot nematode)
Function: Plays a role in the differentiation or division of feeding cells (syncytia) induced in plant roots during infection. Promotes host root growth.
Subcellular location: Secreted {ECO:0000269|PubMed:16673933}. Host cytoplasm {ECO:0000250}. Host extracellular space {ECO:0000250}. Note=Secreted into host root cells via the nematode stylet to transform the recipient cells into enlarged multinucleate feeding cells called giant-cells or syncytia.
Interaction partners:
Sequence:
MFTNSIKNLIIYLMPLMVTLMLLSVSFVDAGKKPSGPNPGGNN
Protein: Netrin-1 (Epididymis tissue protein Li 131P) (O95631)
Organism: Homo sapiens (Human)
Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Subcellular location: Secreted {ECO:0000269|PubMed:28945198}. Cytoplasm {ECO:0000269|PubMed:28945198}. Note=Mainly secreted. {ECO:0000269|PubMed:28945198}.
Interaction partners:
- Netrin receptor UNC5A
- Cell adhesion molecule DSCAM
- Netrin receptor UNC5B
- Netrin receptor DCC
- Netrin receptor UNC5C
- Neogenin
- Netrin receptor UNC5D
- Draxin
- Repulsive guidance molecule B
- Slit homolog 3 protein
Sequence:
MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKINMKKYCKKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA
Protein: 4'-phosphopantetheinyl transferase Sfp (EC 2.7.8.7) (Surfactin synthase-activating enzyme) (P39135)
Organism: Bacillus subtilis (strain 168)
Function: Activates the seven peptidyl carrier protein (PCP) domains of the first three subunits (SrfAA, SrfAB and SrfAC) of surfactin synthetase by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for cells of B.subtilis to become producers of the lipopeptide antibiotics surfactin and plipastatin B1.
Interaction partners:
Sequence:
MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRTLLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQPIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQEGKGLSLPLDSFSVRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAAHPDFPEDITMVSYEELL
Protein: Cytochrome c oxidase assembly protein COX20, mitochondrial (Q04935)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the assembly of the cytochrome oxidase complex. Required for the maturation and subsequent assembly of the mitochondrially encoded COX2, the precursor of subunit 2 of cytochrome oxidase.
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cytochrome c oxidase subunit 2
- Protein SOM1, mitochondrial
- Cytochrome c oxidase assembly protein COX18, mitochondrial
Sequence:
MRWWPWSNQTEDQKQQQQPQGKADGDRVLTNYSRGQKILLEDTPPKFADDLSNSQLAKKQERATLKEAWDSIRWSDFSLQKLTSIPCFRDAGMLGFSSMFLMGSIIFIYHKSPTKATNWAMSSLILGSIVGWEQCRLKRQKSFQIAQLAKETVAKKEKPMLHNVPHDPSLPGQWEAAKNEKQSQFEQSNQNLSQASSEKKWYKFW
Protein: Putative ABC transporter, permease protein (Q608U0)
Organism: Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- ABC transporter, ATP-binding protein
- Arylesterase
- Putative ABC-transporter permease protein
- Putative ABC transporter, permease protein
Sequence:
MRAAYGFRLAWRLARRDWRGGELGVLLAALLIAVAATAATQLFSDRLARTMVDHAAEFIAGDLTLASHRQIPPEWLEQAASLGLKHAASVELPSVLMENEQILLGGIKAVSPAYPLRGEVRTRAAGAVDERPAGGIPQPGTVWVESRVLTTLGLTLGASLTVGSAQFRVERLLTHEPDRRGDLYSLSPRVIMNLGDLPATRVIQPGSRVHYYDMFAGKDTAVRRFKAWLRPRLQRGERLLDVHEDRPEVGTALNRAERYLGMTGVMIVLIAGVAIGMSARRYTERHSDTTALLKCMGATKNDILAIHICVLMMVGLPGSLLGSALGYLVQAAIARSVAGLLPHDLAQPGLESLLTAPLIGMVILVGFAVPPLPELMRVPPLRVLRRDLGPTPPSVWLGLGIAIVTLAALLLRPARDPALVGFVLMGGAATLAGFGFCLDGLLRLLPRLLRRRPLVWRLGLHSLLRRRRLASVQIMGFGLAMAAMLISHVVQNELVSEWKRQSPDNVPNFFALNLQETELDRFRQMLEAESIESSGIYPIVRGRLVSVDGIDAHELAPKDSHAEAALERDLSLTWSEGLPAGNRIVRGHWWSGVPLRVSVEEKLAAELGIRIGSQLTFDVAGTPVSATVESIRSVRWDAMTPNFYMIFSPRSLQDQPRTYLTSFHVPSGRSTVLSNLVKAFPGITLLDVDALLKQFQSILQQVTLAVQVVLGFAVVAGFTVLFGAVHATAEERLREDALLRALGADTPLLKRSQWIEFAVLGFLAGILAAASTELVGAVAFSRVMNLAPQAHPWLWLAAPCLGAITVGMAGRWSVRRVVAVSPNDVLRDLS
Protein: PDZ domain-containing protein (O02063)
Organism: Caenorhabditis elegans
Interaction partners:
- Phosphate carrier protein
- PH domain-containing protein
- BAR domain-containing protein
- non-specific serine/threonine protein kinase
- Expressed conserved protein
- Regulator of microtubule dynamics protein 1
- AAA+ ATPase domain-containing protein
- DUF1248 domain-containing protein
- Nematode Specific Peptide family, group D
- Nematode Specific Peptide family
Sequence:
MGSEKMIEICIDMEEGEPLGATPNDKLVITKIQAGTISEGKLRIGDQVKKVNGQNCKDCNDFFRALRFAAPCAKITVNRDEKKAEELEARVHIPEDRAKIIQRREGYVYELATLVWVQNGPKLGLGIKHFQNRVLVSRVDPGSLAEKCLVLGDHLCDVDGIPVSDKDVARDLLVKNIQEKGKVTFVVERPDSIDAKQWAKQALATNLMQPPSVQMNEDVKGIASQYRQALPGLKPPAKSAMSTGPNARRVSIIEQTQTHEIGHDHEGKALRKVK
Protein: CCR4-NOT transcription complex subunit 3, isoform A (CCR4-NOT transcription complex subunit 3, isoform B (EC 3.1.13.4)) (LD13864p) (MIP07457p) (Q7K126)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 4
- poly
- Not1, isoform H
- CCR4-NOT transcription complex subunit 9
- Regulator of gene activity
- CCR4-NOT transcription complex subunit 11
- Protein associated with topo II related - 1, isoform A
- poly
- ATP-dependent RNA helicase me31b
Sequence:
MAATRKLQGEIDRCLKKVAEGVETFEDIWKKVHNATNTNQKQKHLQEKYEADLKKEIKKLQRLRDQIKSWIASAEIKDKSSLLENRRLIETQMERFKVVERETKTKAYSKEGLGAAQKMDPAQRIKDDARNWLTSSISSLQIQIDQYESEIESLLAGKKKRLDRDKQERMDDLRGKLDRHKFHITKLETLLRLLDNDGVEAEQVNKIKDDVEYYIDSSQEPDFEENEFIYDDIIGLDEVELSGTATTDSNNSNETSGSPSSVTSGGSPSQSPVTVQQILNTSSQGAASSGSSAASAALFQQQLTAAQSNGNNVGYASDTSAASSSATTSTDPAGGTVAVNCVGGLADKRNKSSESNALKLKPQPHQLIKPTPVRATAKLPLSSDTQVNKIVSSTPSKNQQQLPTAASIVATSAMQSQSSIGSCSSTGGTGASQSASSGNNPGNNPAVQPNAPTPGQSGIAAAAASTNVVSATIVSSANVQGQSVIQPTPTIAFAAVAKHNTSLLENGPVLQQQLAVTPTVAAIVGAGTQAQQKHVPPLSNLQTNSPHIQNGLPVSDSTNDNSCNVVDTISLKTMAQDAINRSAIDPNSLNQQQTSSIDLRQPQSQKSLLQHFNSETNTNQQQLTSQQQQQLQNNSLAATTGSNNGTSTGSGLMNVANATGQPISGNAKTHACQPQQMATTEAHIPTLLGVTPLGPTPLQKEHQMQFQMMEAAYYHLPQPMDTEKLQTYFHRAPVLTPSHYPQAQMPIYDTVEFYQRLSTETLFFVFYYMEGSKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKIINDDYEQGTYIYFDYEKWSQRKKEGFTFEYKYLEDKELN
Protein: Mitochondrial import inner membrane translocase subunit Tim8 B (DDP-like protein) (Deafness dystonia protein 2) (Q9Y5J9)
Organism: Homo sapiens (Human)
Function: Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim13
- Mitochondrial import inner membrane translocase subunit Tim10
- Mitochondrial import inner membrane translocase subunit Tim9
- Mitochondrial import inner membrane translocase subunit Tim10 B
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Dipeptidyl peptidase 2
- Mitochondrial import inner membrane translocase subunit Tim23
- Mitochondrial import inner membrane translocase subunit Tim22
- Thioredoxin domain-containing protein 17
- Mitochondrial import receptor subunit TOM22 homolog
Sequence:
MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCVDRFIDTTLAITSRFAQIVQKGGQ
Protein: Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3-oxoacyl-CoA synthase 1) (A0A0R4IT00)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|HAMAP-Rule:MF_03201}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03201}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Elongation of very long chain fatty acids protein 1
- Very-long-chain 3-oxoacyl-CoA reductase-A
- Very-long-chain 3-oxoacyl-CoA reductase-B
- 20beta-hydroxysteroid dehydrogenase type 2
Sequence:
MLETVKDRVLEAYGSLLAARDPRLKDYPLMESPFSMTAILLAYLFFVLYAGPKFMANRKPFQLKEAMIIYNLSLVGLSAYIVYEFLMSGWATGYTWRCDPCDYSNSPQGLRMARVAWLFLFSKFIELMDTVFFVLRKKHSQITFLHIFHHSFMPWTWWWGVSIVPGGMGSFHAMVNSCVHVIMYFYYGLSAAGPRFQKFLWWKKYMTAIQLTQFVLVSLHVSQWYFMESCDFQVPVIIHLIWLYGTFFFVLFSNFWYQAYIKGKRLPKNTQETTKTNGSTIVTNGSSGVSNGHAIHENGLSNGKKHHENGNALNGKMKKA
Protein: Rab GTPase-binding effector protein 2 (B4DHR0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Early endosome {ECO:0000256|ARBA:ARBA00004412}.
Interaction partners:
Sequence:
MAAAAPVAADDDERRRRPGADSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT
Protein: Trypsin delta (EC 3.4.21.4) (C0HKA2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted, extracellular space {ECO:0000250|UniProtKB:P04814}.
Interaction partners:
- Bazooka, isoform B
Sequence:
MLKFVILLSAVACALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSSNVIVTAAHCLQSVSASVLQIRAGSSYWSSGGVTFSVSSFKNHEGYNANTMVNDIAIIKINGALTFSSTIKAIGLASSNPANGAAASVSGWGTLSYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRSTMICAAASGKDACQGDSGGPLVSGGVLVGVVSWGYGCAYSNYPGVYADVAALRSWVISNA
Protein: Probable NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (FDXR) (Ferredoxin reductase) (P48360)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Adrenodoxin reductase transfers electrons from NADPH to adrenodoxin, which subsequently donates them to the cytochrome P450 forms.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:9727014, ECO:0000269|PubMed:9818721}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Adrenodoxin homolog, mitochondrial
- Glutamate synthase
- Heme A synthase COX15
- Protoheme IX farnesyltransferase, mitochondrial
- Protein ISD11
- Cysteine desulfurase, mitochondrial
- Frataxin homolog, mitochondrial
- Probable electron transfer flavoprotein subunit beta
- Dihydroorotate dehydrogenase
- Iron sulfur cluster assembly protein 1, mitochondrial
Sequence:
MSFVQIRHISSQINRKTVSIVGSGPSGFYTAYHLLKKSPIPLNVTIWEKLPVPFGLSRYGVAPDHPEVKNCEETFTTCAEEFSSPTNQKHKFSFVGGITIGKEILLKELLDNQDAVILSYGCTGDRKLNIPGELGTKGVFSSREFVNWYNGHPDFAKDKRFTDFDWSKVSKVGIIGNGNVALDITRVLISNQIDEIWENTDISSLALNLLRRAPVKDVKLIARRDFVHSKFTNKELRELWELEKYGIRGRIDPKFFQKEMFDPSKYDRAFNRRVEMCSEYLKPFNERSKKNYKKAPPPSSGYDKFWELDYLKTPLKINRDDFGAINSLSLCNNRLNEDNSLQPLKDVNNIMTYKVDLLITSLGYAGVPMPEFSKLSIGFDKDHIANKQGRVLTSSGEIFPHLYASGWIRKGSQGVIASTMQDAFEVGDRVIQDLVVSGALSLENSIDLSNIKHTTWKDWERINKKELLRGKKEHKTRSKFLTFEELWNGVEGI
Protein: Protein NAR1 (Nuclear architecture related 1) (Protein GROWTH AT DIFFERENT OXYGEN LEVELS INFLUENCES MORPHOGENESIS) ([FeFe]-hydrogenase-like protein GOLLUM) (Q94CL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe/S proteins (By similarity). Required for expression of the imprinted FWA gene, for seed development and is involved in the oxidative stress response in vegetative tissues. Involved in the regulation of cell size, ploidy and cell cycle progression. Required for growth under normoxic conditions and necessary for recovery after hypoxic treatment but its action is reactive oxygen species (ROS) independent.
Subcellular location: Nucleus {ECO:0000269|PubMed:23639116}. Cytoplasm {ECO:0000269|PubMed:23639116}.
Interaction partners:
- MMS19 nucleotide excision repair protein homolog
- Protein AE7
- Cytosolic Fe-S cluster assembly factor NBP35
- Protein CIA1
- Protein CHLOROPLAST IMPORT APPARATUS 2
- Fe-S cluster assembly factor HCF101, chloroplastic
- Protein AE7-like 2
- Anamorsin homolog
- NADPH-dependent diflavin oxidoreductase 1
- Ferredoxin-1, chloroplastic
Sequence:
MSEKFSPTLRLGDLNDFIAPSQACVISLKDSKPIVKKSDRPQVVIAPKQQLEPVKISLKDCLACSGCITSAETVMLEKQSLDEFLSALSKGKDVVVSVSPQSRASLAVHYDISPLQVFKKLTTFLKSLGVKAVFDTSCSRDLVLIESCNEFVSRYKQANSDDGENSQSPLPVLSSACPGWICYAEKQLGSYVLPYVSSVKSPQQAIGAAIKHHLCQALGLRLHEVYHVTVMPCYDKKLEAARDDFVFDDGTQDNGDLKLTEVDSVLTTGEIMDLIKLKGVDFKDLEESPLDRVLTNVTEEGDLYGVAGSSGGYAETIFRHAAKALFGQTIEGPLEFKTLRNSDFREVTLQLEGKTVLKFALCYGFQNLQNIVRRVKTRKCDYQYVEIMACPAGCLNGGGQIKPKTGQSQKELIHSLEATYMNDTTLNTDPYQNPTAKRLFEEWLKEPGSNEAKKYLHTQYHPVVKSVTSQLNNW
Protein: Protein-tyrosine sulfotransferase 1 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 1) (TPST-1) (O60507)
Organism: Homo sapiens (Human)
Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16859706, ECO:0000269|PubMed:25660941}; Single-pass type II membrane protein {ECO:0000269|PubMed:25660941, ECO:0000305|PubMed:16859706}.
Interaction partners:
- Gastrin
- Ribosome maturation protein SBDS
- Coagulation factor VIII
- Podocalyxin-like protein 2
Sequence:
MVGKLKQNLLLACLVISSVTVFYLGQHAMECHHRIEERSQPVKLESTRTTVRTGLDLKANKTFAYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQMWSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFALKSLTYLSRLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNHSVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQDMAVIAPMLAKLGYDPYANPPNYGKPDPKIIENTRRVYKGEFQLPDFLKEKPQTEQVE
Protein: CLIP-associating protein (Q55BD8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Microtubule-associated protein RP/EB family member 1
Sequence:
MTNQEEISEIILKLCTKNQDGQDDMISILRGYKLLLEFFKSKLLEFDSFIEISNILIKHLRKENNEIIIMKLLECSKFIIDILSDQIDEECIDILNQLINCFFNLLGNDDYSIDLELEESIFENVKIIISNLIQYFGFNRILPFLERIIKNNNNREIENSLKIINHLIIESTSTSSPIIDIKDIQPLLNDLITLFTLQNHQSKFPSLNSLIIHFFNEYGNNFFNTCIDYNSLNNSIKKELSTLFNSFEKKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKQQQQKQQNNNKSNESSNEFDTIENTSGNSSFNNSCGSENFSNSSKCINNSFRDISNRVSNFVAAAKLQQQQQQQQQQQQQQQHQQQQQQKPIQEDRFSKLSKKPLGIHSLINNLTESDFEYKMNEIIEILSNSDTEWSIKLNNILKFQAIIKSGACKLSNFIIVFNRIKELLALQILDKRSILMKEACLTLSLIAKELEHHFEPYLEKYFDVLLKCIVVTTKIVSESSDNCIKCIISSSKSCKIIPRIYEAISSDKSVIIRSKCTEYLYILLRDLPSSSGNHHHHHHLFEKHLDSIEKSIRIGVVDANLTARSYSRKVFIQFSLNWPDRSNSLFSTLDPSAQKTIESELSGNNIIGSISSSSISSSYSGGGGSSSSLKTPLTKKIITNSTPTSSITNKPRSNVLTTSTSSSFLPQRNVDLSTPKLTPSHVSSSISSISSISSISSISGGQPTFQIGKPLISNRPSIKKISTPPLISKNFTSSIITPPHHNFSINSSISSSSSNRSSSSSNDSYEKKRLFSSVTDSLPSRKKQMISHPSSPDSIRQQHTSILEQPFKTISTSSSSSTSLIKQPLKISKSITNNTISSGNPIKNYVRDIHNQQSKLLANQK