wanglab/gogpt-training-data huggingface dataset:
Protein: 5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73) (P21589)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate. Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms. Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN.
Subcellular location: Cell membrane {ECO:0000269|PubMed:2129526, ECO:0000269|PubMed:24887587}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2129526}.
Interaction partners:
- Ectonucleoside triphosphate diphosphohydrolase 1
- Purine nucleoside phosphorylase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenosine deaminase
- Uridine phosphorylase 1
- NAD-capped RNA hydrolase NUDT12
- Uridine phosphorylase 2
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- Adenosine kinase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
Sequence:
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
Protein: Nucleoporin NUP42 (Nucleoporin-like protein 2) (C9JYA1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus membrane {ECO:0000256|ARBA:ARBA00004335}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004335}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004335}. Nucleus, nuclear pore complex {ECO:0000256|ARBA:ARBA00004567}.
Interaction partners:
Sequence:
MAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQPQQQPSGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWESSGQWMFSVYSPVKKKPNISGFTDISPEELRLEYHNFLTSNNLQSYLNSVQRLINQWRNRVNELKSLNISTKVALKCLWKIYTHLSPKIYGPDCGKFIIFLSDVKDGVNQAAPAFGFGSSQAATFMSPGFPVNNSSSDNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAASFSFKSPAASSFGSPGFSGLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEELEQFQSKKFTLGK
Protein: Nucleolar MIF4G domain-containing protein 1 isoform 2 (Nucleolar protein with MIF4G domain 1) (Q1LY16)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MASISSQLEELYMNTSRKDMNDTLTDILLAACVTPALMPERLLMEHILLVSVLHYSVGLEVGAHFLETVVRQFDRIYSELDGTDKECDNLVSIIAHLYNFHVVHAVLVFDILKKLVTSFSSKDIELLLLVLKTVGFALRKDDPIALKELISEAQRKASAEGEQFQDQTRIRFMLETMMALKNNDMRKIPGYDPEPVEKLRKLQRTLIHSSAGSSDMKLRVSLDNLLEAERVGRWWIVGSSWSGAPMIDDQGNKTTTPSTKGEQYSAKMLELARKQRMNTDVRRNIFCVLMSSEDFLDAYEKLLRLGLKDQQEREIVHVLMDCCLQEKMFNRFYAVLAEKLCSHDRRFQMTFQFSLWDKFRDLANLSNRSFSNLVQLVTHLLHRKSLSLSILKAIEFGELDKPKVKFLKQILSKLLKETEPEDLVNIFGRISGIPKLGMLREGLKLFISHFLLRTVNTQEPPEQAKVLKDRAEVATKAMEARDAKIKL
Protein: FT-interacting protein 7 (OsFTIP7) (Q60EW9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Promotes nuclear translocation of the transcription factor OSH1, which directly suppresses the auxin biosynthetic gene YUCCA4 during the late development of anthers. Reduction of auxin levels at late stage of anther development, after meiosis of microspore mother cells, is necessary for normal anther dehiscence and seed setting. Required for jasmonate (JA) biosynthetic genes expression and JA production in anthers.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29915329}; Multi-pass membrane protein {ECO:0000255}. Note=May be associated with the endoplasmic reticulum membrane in the close vicinity of the plasma membrane. {ECO:0000305|PubMed:29915329}.
Interaction partners:
Sequence:
MMQRPFRPEEYSLKETSPHLGGGAAGDKLTTTYDLVEQMQYLYVRVVKAKDLPSKDITGSCDPYVEVKLGNYKGTTRHFEKKTNPEWNQVFAFSKERIQSSVVEIIVKDKDFVKDDFIGRVLFDLNEVPKRVPPDSPLAPQWYRLEERNGHKVKGELMLAVWMGTQADEAFPEAWHSDAASIPGDGLASIRSKVYLTPKLWYLRVNVIEAQDLIPNDRTRFPDVYVKAMLGNQALRTRVSPSRTLNPMWNEDLMFVAAEPFEEHLILSVEDRIAPGKDDVLGRTIISLQHVPRRLDHKLLNSQWYNLEKHVIVDGEQKKETKFSSRIHLRICLEGGYHVLDESTHYSSDLRPTAKQLWKHSIGILELGILTAQGLLPMKTKDGRGTTDAYCVAKYGQKWVRTRTIIDSFTPKWNEQYTWEVYDPCTVITIGVFDNCHLNGGEKANGARDTRIGKVRIRLSTLETDRVYTHAYPLIVLTPAGVKKMGEVQLAVRFTCSSLLNMMHLYSQPLLPKMHYVHPLSVMQVDNLRRQATNIVSTRLSRAEPPLRKEIVEYMLDVDSHMWSMRKSKANFFRIMGVLSPLIAVAKWFDQICHWRNPLTTILIHILFVILVLYPELILPTIFLYLFLIGVWYYRWRPRQPPHMDTRLSHAESAHPDELDEEFDTFPTSRPPDIVRMRYDRLRSVAGRIQTVVGDLATQGERLQSLLSWRDPRATALFVTFCFVAAIVLYVTPFRVVVFLAGLYTLRHPRFRHKMPSVPLNFFRRLPARTDSML
Protein: Zinc finger protein 76 (Zinc finger protein 523) (P36508)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- T-complex protein 11 homolog
Sequence:
MESLGLHTVTLSDGTTAYVQQAVKGEKLLEGQVIQLEDGTTAYIHQVTVQKEALSFEDGQPVQLEDGSMAYIHRTPREGYDPSTLEAVQLEDGSTAYIHHPVAVPSESTILAVQTEVGLEDLAAEDDEGFSADAVVALEQYASKVLHDSQIPRNGKGQQVGDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFQCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELEATEESEQALYEQQQLEAASAAEESPPPKRPRIAYLSEVKEERDDIPAQVAMVTEEDGAPQVALITQDGAQQVSLSPEDLQALGSAISMVTQHGSTTLTIPSPDADLATSGTHTVTMVSADGTQTQPVTIITSGAVVAEDSSVASLRHQQVALLATANGTHIAVQLEEQQTLEEAINVATAAMQQGAVTLETTVSESGC
Protein: Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) (O94906)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:10561546, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34023904}. Nucleus speckle {ECO:0000269|PubMed:21549338}. Note=Localized in splicing speckles. {ECO:0000269|PubMed:21549338}.
Interaction partners:
- Splicing factor 3B subunit 3
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Small nuclear ribonucleoprotein F
- U4/U6 small nuclear ribonucleoprotein Prp4
- U4/U6 small nuclear ribonucleoprotein Prp31
- Splicing factor 3B subunit 2
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein E
- U4/U6.U5 tri-snRNP-associated protein 1
- U4/U6 small nuclear ribonucleoprotein Prp3
Sequence:
MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPRHGELWCAVSKDIANWQKKIGDILRLVAGRIKNTF
Protein: Cell wall protein phiA (Bafilomycin-induced protein B) (Phialide development protein A) (Q5ATP7)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Cell wall protein involved in development of asexual structures such as phialide and conidium development, and thus required for spore formation. Plays a role as a general stress protectant produced by the fungus in competition with antagonistic bacteria (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:D4AV66}. Secreted, cell wall {ECO:0000269|PubMed:14599891}.
Interaction partners:
Sequence:
MKLTSTAALASLAVAATAAPSTPETFGLVAIRSGDAVQYAGFNAALGSIFAGLPKQNATCEGTDSGFATFYIKDGALYLYGSEETQEIYVDRSGMGQGLIGYTTGDNASGPRNSERTGWSIDENNHLVFDGNSLIACPNSIDSAYSIWASAGVANPGGNKDCVGIAARVEKTENPIACTYSS
Protein: Periplasmic nitrate reductase (EC 1.9.6.1) (O88111)
Organism: Cereibacter sphaeroides f. sp. denitrificans
Subcellular location: Periplasm {ECO:0000256|HAMAP-Rule:MF_01630}.
Interaction partners:
Sequence:
MTLTRRDLIKAQAAATAAAAAGLPVSALAQPVTGGAEALRIRWSKAPCRFCGTGCGVMVGTRDGQVVATHGDTQAEVNRGLNCVKGYFLSKIMYGEDRLTTPLLRMKDGVYHKEGEFAPVSWDEAFDVMAAQAKRVLKDKGPKAMGMFGSGQWTIWEGYAASKLMRAGFLSNNLDPNARHCMASAATAFMRTFGMDEPMGCYDDFEAADAFVLWGSNMAEMHPILWSRLTDRRLSHEHVRVAVLSTFTHRSMDLADTPIIFRPGTDLAILNYIAHHIISTGRVNRDFVDRHTNFALGATDIGYGLRPEHQLQLIAKGAADAGAMTPTDFETFAALVSEYTLERAAEISGVEPALLEELAELYADPDRKVMSLWTMGFNQHVRGVWANHMVYNLHLLTGKISEPGNSPFSLTGQPSACGTAREVGTFAHRLPADMVVTNPEHRAHAEEIWKLPAGLLPDWVGAHAVEQDRKLHDGEINFYWVQVNNNMQAAPNIDQETYPGYRNPENFIVVSDAYPTVTGRCADLVLPAAMWVEKEGAYGNAERRTHFWHQLVEAPGEARSDLWQLMEFSKRFTTDEVWPEEILAAAPAYRGKTLFEVLFANGSVDRFPVSDVDPDHANHEAALFGFYPQKGLFEEYAAFGRGHGHDLAPFDTYHEVRGLRWPVVEGEETRWRYREGYDPYVKPGEGLRFYGKPDGRAVILGVPYEPPAESPDEEFGFWLVTGRVLEHWHSGSMTLRVPELYKAFPGAVCFMHPEDARSRGLNRGSEVRVISRRGEIRTRLETRGRNRMPRGVVFVPWFDASQLINKVTLDANDPISRQTDFKKCAVKIEAV
Protein: Low molecular weight phosphotyrosine protein phosphatase 1 (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase 1) (EC 3.1.3.2) (PTPase 1) (P82890)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
Subcellular location: Cytoplasm.
Interaction partners:
- Arginine phosphatase
- Thiamine pyrophosphokinase 1
- Low molecular weight phosphotyrosine protein phosphatase 2
- Putative riboflavin kinase
- IP06402p
- GH19849p
- FAD synthase
- acid phosphatase
- FAD synthase
- Uncharacterized protein, isoform B
Sequence:
MVRKVLMICLGNICRSPIAEVVMVDTLEKANVKDVEVDSAAIGGWHVGNRADPRAISTLQKHGLKCTHIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAPKGSKAELLMLGDFGLEKKNRIIEDPYYERGAEGFETAYQQCVVACAAFMKERLQK
Protein: Leukocyte ribonuclease A-2 (Q27J90)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAMSSLWWTAILLLALTVSMCYGVPTYQDFLYKHMDFPKTSFPSNAAYCNVMMVRRGMTAHGRCKSFNTFVHTDPRNLNTLCINQPDQALRTTRRHFRITDCKLIRSHPTCRYSGNQFNRRVRVGCRGGLPVHLDGTSP
Protein: Probable replication factor A 73 kDa subunit (RP-A p73) (Replication factor A protein 1) (RF-A protein 1) (Q19537)
Organism: Caenorhabditis elegans
Function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
Subcellular location: Nucleus {ECO:0000269|PubMed:30383754}.
Interaction partners:
- Replication protein A C-terminal domain-containing protein
- RecQ-like DNA helicase blm-1
- DNA topoisomerase 3
- RPA_C domain-containing protein
- RecQ-mediated genome instability protein 1
- DNA topoisomerase
- DNA repair protein RAD51 homolog
- Protein TIPIN homolog
- DNA polymerase delta catalytic subunit
- Protein timeless homolog
Sequence:
MAAIHINHDVFNKYHTNGKLRLTTGYVQEAIENNGYPGHDGIVQVLKGKVEQGEQLGHAFTFRIRISDGVFQYNALMSADIDDQIKREVEHLVEGTIIALTKFEIYDQGEGAKNCFLIKGYKILSRYHQVLTSPEVKPRSHSGKPDEHKGYRPNIIIEDVWPEAEGMAADYQENMANPPAAKAPKREFGEEASYNRAAAPEATRARAVPPPARRTASNTERGVMPIAMVTPYVSNFKIHGMVSRKEEIRTFPAKNTKVFNFEITDSNGDTIRCTAFNEVAESLYTTITENLSYYLSGGSVKQANKKFNNTGHDYEITLRSDSIIEAGGELLAAPKLILKRVKLGEIAGYAGQLIDVLVVVEKMDPEATEFTSKAGKSLIKREMELIDESGALVRLTLWGDEATKALVDDYVQKVIAFKGVIPREFNGGFSLGTGSATRIISVPEIAGVSELYDWYANVKPTTEVKMMSQAAGGSNEAPRTIAGLQEMQFGKDSDKGDYATVKAMITRVNPTNALYRGCASEGCQKKLVGENGDYRCEKCNKNMNKFKWLYMMQFELSDETGQVYVTAFGDSAAKIVGKSAAELGELHDESPDEYNAIFERLQFVPKMWRLRCKMDSYNEEVRQKMTVYGVDDVNQDKYIENLKQMIEQMQQMSDY
Protein: Cdc2 protein (Q9GKX0)
Organism: Sus scrofa (Pig)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSRRVLHRXLKPQNLLIDDKGTIKLADF
Protein: Imidazoleglycerol-phosphate dehydratase 1, chloroplastic (IGPD 1) (EC 4.2.1.19) (Protein HISTIDINE BIOSYNTHESIS 5A) (P34047)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Imidazole glycerol phosphate synthase hisHF, chloroplastic
- Histidinol dehydrogenase, chloroplastic
- Histidinol-phosphate aminotransferase 1, chloroplastic
- Histidine biosynthesis bifunctional protein hisIE, chloroplastic
- 1-
- ATP phosphoribosyltransferase 2, chloroplastic
- Histidinol-phosphate aminotransferase 2, chloroplastic
- ATP phosphoribosyltransferase 1, chloroplastic
- Helicase protein with RING/U-box domain-containing protein
- Bifunctional phosphatase IMPL2, chloroplastic
Sequence:
MELSSASAILSHSSSAAQLLRPKLGFIDLLPRRAMIVSSPSSSLPRFLRMESQSQLRQSISCSASSSSSMALGRIGEVKRVTKETNVSVKINLDGTGVADSSSGIPFLDHMLDQLASHGLFDVHVRATGDVHIDDHHTNEDIALAIGTALLKALGERKGINRFGDFTAPLDEALIHVSLDLSGRPYLGYNLEIPTQRVGTYDTQLVEHFFQSLVNTSGMTLHIRQLAGENSHHIIEATFKAFARALRQATETDPRRGGTIPSSKGVLSRS
Protein: RUN and FYVE domain containing 1 (H0YAC8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKDCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNE
Protein: Glutathione peroxidase (Q5UTE7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Glutathione reductase
- Glutathione peroxidase
- Glutathione S-transferase omega
- Glutathione peroxidase
- Glutathione peroxidase
- Peroxiredoxin-6
- Peroxiredoxin-6
- Superoxide dismutase
- Glutathione S-transferase kappa
- DSBA-like thioredoxin domain-containing protein
Sequence:
MNELHERYADKGLVILGVPCNQFGHQENCKNEEILMSLKYVRPGNGFEPKFQLLEKVDVNGKDAHPLFVYLKDKLPFPSDEPMALMNDPKCIIWSPVCRTDIAWNFEKFLIGPAGEPFKRYGRRFLTSNIEGDIKELLNTAN
Protein: Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60) (Q13105)
Organism: Homo sapiens (Human)
Function: Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1.
Subcellular location: Nucleus {ECO:0000269|PubMed:14739298, ECO:0000269|PubMed:9312026}.
Interaction partners:
- Myc proto-oncogene protein
- Protein max
- Transcription factor Sp1
- B-cell lymphoma 6 protein
- DNA topoisomerase 2-binding protein 1
- Zinc finger and BTB domain-containing protein 4
- N-myc proto-oncogene protein
- E3 ubiquitin-protein ligase HUWE1
- Histone acetyltransferase p300
- X-box-binding protein 1
Sequence:
MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE
Protein: Guanylate-binding family protein (F4KG14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT5g59210/mnc17_100
- DNA ligase-like protein
- AT5g22320/MWD9_11
- Nucleolar GTP-binding protein 1
- Carbohydrate-binding-like fold
- At1g13730
- AT5g25280/F18G18_20
- AT5g42220/K5J14_2
- Clustered mitochondria protein
- UPF0057 membrane protein At4g30650
Sequence:
MRSFFGRGGKDSPADSASPSPRSYPSTSPASSSAVTGPPRPIRLVYCDEKGKFRMDPEAVATLQLVKEPIGVVSVCGRARQGKSFILNQLLGRSNGFQVASTHKPCTKGLWLWSSPIKRTALDGTEYNLLLLDSEGIDAYDQTGTYSTQIFSLAVLLSSMFVYNQMGGIDEASLDRLSLVTQMTKHIRVKASGGTSSRSELGQFSPIFVWLLRDFYLDLVEDNRKISPRDYLEIALRPVQGSGGDIGAKNEIRDSIRALFPDRECFTLVRPLNNEKDLQRLDQISLEKLRPEFGAGLDAFTKFVFEKTRPKQLGGTVMTGPILVGITQSYLDALNNGAVPTITSSWQSVEETECRRAYDSGVEAYMAAFDQSKAPEEGALREEHEEAVRKALAIFNSNAVGNGSARKKFEDLLHKDLKKKFEDYKKNAFMEADLRCTSTIQRMEKQLRAACHASNANMDNVVKVLEARLAEYEASCHGPGKWQKLSVFLQQSLEGPIYDLTKRLIDSIAIEKNSLAMKFRSVEDAMKHLKQQLDDSERYKLEYQKRYDESNNDKKKLEDIYRERITKLQGENSSLNERCSTLVKTVESKKEEIKEWIRNYDQIVLKQKAVQEQLSSEMEVLRTRSTTSEARVAAAREQAKSAAEETKEWKRKYDYAVGEARSALQKAASVQERSGKETQLREDALREEFSITLANKDEEITEKATKLEKAEQSLTVLRSDLKVAESKLESFEVELASLRLTLSEMTDKLDSANKKALAYEKEANKLEQEKIRMEQKYRSEFQRFDEVKERCKAAEIEAKRATELADKARTDAVTSQKEKSESQRLAMERLAQIERAERQVENLERQKTDLEDELDRLRVSEMEAVSKVTILEARVEEREKEIGSLIKETNAQRAHNVKSLEKLLDEERKAHIAANRRAEALSLELQAAQAHVDNLQQELAQARLKETALDNKIRAASSSHGKRSRFEDVVDMDIGEGSDRILRTNKRARSTRGDDHGPTDEGDEDFQSHQDNGEEEEEEDYRKLTVQNLKHELTKYDCGHLLLNRGHQNKKEILALYEAHVLPKKALAREEERKKQREVTSS
Protein: Serine/threonine-protein kinase STE7 homolog (EC 2.7.12.2) (Q5A6T5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- mitogen-activated protein kinase kinase kinase
- Extracellular signal-regulated kinase 1
- Mitogen-activated protein kinase
- Cst5p
- Transcription factor CPH1
- G protein subunit beta
- Mitogen-activated protein kinase kinase kinase
- Ste50p
- High osmolarity signaling protein SHO1
- Ras-like protein 1
Sequence:
MTRTTRIDTQEATKHKDLPPVPSPLSLSSNPNPECLMESKSLGRKNFKKLSLDASPVKSTSGSLRSSDMMSIKEPTSLRQKRQRPPPILHLPTASSSATSTPTSNITGSSSASSIQFAQKSPGSGVIVSQTLSRPSSAGGIPSSGYSSLNVNQSNRNVDPDNVVSTDMILNQISNLDLTSMNHHRQHYQNSHHHLPTTNRKRQTVISSISPTKSSAASSSLEPQIQSLPASSQSPIATTSSLKLNNKDLLTLKQLGSGNSGSVSKILHIPTQKTMAKKIIHIDSKSVIQTQIIRELRILHECHSPYIIEFYGACLNNNNTIVICMEYCNCGSLDKILPLCENKQFPTFVLKKLSFAILSGLTYLYTTHKIIHRDIKPNNVLMTHKGEFKLCDFGVSRELTNSLAMADTFVGTSMYMSPERIQGLDYGVKSDVWSTGLMLIELASGVPVWSEDDNNNDDDEDDEDDAYVRQGSIAAERNGQNSPSRSRKNKQKGNGYNSYNGPEGILDLLQRIVNEDAPTLTNKINPVTKLPYDKYLCQFIDLCLIKDDSVRKTPWQLLEDKEHFFKGVEEGVYDKEHKSWAKKIRKCKV
Protein: UPF0046 protein T07D4.2 (Q22306)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MLSPALLKVSLNRRSSAPVPQDEKMMFHSRNRAASYLQPMIEDQELIGFNRDRRRSSGSIIVDSFELGNASPSRRGSIASGIPMDKKTRRKLSNPVSLHQYTEDPTLAWEMLKEKRPVKPVRQMRLDTPVKPDHVRFVCIGCTHGEQFDISKLPPGDVLLVAGDFTSCGLPNEVHNFNKLLGKLKYSYKVVIGGNHECTFDDTFLKLKQESEPKEMALKQALLSAIHSDSKGGISAKDLLSNAIYLEDNVIELFGITIYGTPWQPKVDNWAFNLSRGQQLLDKWNLIPAGVDVLLTHTPPLGHGDMMNNGQRMGCAELLNTVFKRVRPKYHVFGHIHEGYGCTTDGYTKFINCCMCNENLDLKNEPVIFDIPVHPHTKQFYIQNVKKIHKRFQKKK
Protein: RNA-binding (RRM/RBD/RNP motifs) family protein (T16E15.6 protein) (Q9LME7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSNTSYYRSPFGDTTHTKVFVGGLAWETPTDEMRRYFDQFGEILEAVIITDKATGKSKGYGFVTFRDSDSATRAVADPNPVIDGRKANCNIASFGRPRPSTPRGRGQGGSPSQYQGGGQSSYTGMAAPVQQAAAAQLMYPSYGYTYNSEYGYHQALYNAQLQQAQYYQQQMYGGGGATSPSSSNIMPSPYYYLQAPSPRPYLHHQQHYQYHHHQQQQQQQQQRLPSASSYLIYPSNVEAPTPSNVPTSQGPLSSSTESHAPQQVSEEGGEFDPTDAPESTTTNIRDLTSSS
Protein: Polynucleotide kinase 3'-phosphatase (M0QYH2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEETRTPESQPDTPPGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITTRSGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAEEFKAKVEAVVEKLGVPFQVLVATHAGLYRKPVTGMWDHLQEQANDGTPISIGDSIFVGDAAGRPANWAPGRKKKDFSCADRLRTVSRSGPLCLPESRALLSASPEVVVAVGFPGAGKSTFLKKHLVSAGYVHVNRDTLGSWQRCVTTCETALKQGKRVAIDNTNPDAASRARYVQCARAAGVPCRCFLFTATLEQARHNNRFREMTDSSHIPVSDMVMYGYRKQFEAPTLAEGFSAILEIPFRLWVEPRLGRLYCQFSEG
Protein: Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) (Q9XY92)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate (By similarity).
Interaction partners:
- S-adenosylmethionine decarboxylase proenzyme
- Probable ornithine decarboxylase
- Arginase/agmatinase/formiminoglutamase family protein
- S-adenosylmethionine synthase
- Probable saccharopine dehydrogenase [NADP
- Amidohydrolase-related domain-containing protein
- Aminoadipic semialdehyde synthase
- Nitrilase homolog 2
- Deaminated glutathione amidase
- Group IV decarboxylase
Sequence:
MDKIQNGWFSEISEFWPGNSFSLEVEKVLHHEKSEYQDFLVFKSKSFGNVLVLDGVIQATERDEFAYQEMITHIPLFSHPSPKRVLVVGGGDGGVLREVVKHPLVESVTLCEIDKGVIEASRNFLPNMRVGFDHPKVTLFIGDGMEFMRQRKGEFDVIITDSSDPIGPAQGLFERAYYELLKAALAPGGIVCSQCESMWLHLDTIKGLTTFCKELYPNVEYAYTSIPSYPGGSIGFILCSLGGSTKAPIREITPEVQSQMQYYNGEVHKASFVLPQFAAKKLNL
Protein: NifU-like protein 2, chloroplastic (AtCNfu2) (AtCnfU-V) (Q93W20)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Molecular scaffold for [Fe-S] cluster assembly of chloroplastic iron-sulfur proteins. Required for biogenesis of ferredoxin, a major photosynthetic electron carrier containing [2Fe-2S] cluster. Required for the assembly of photosystem I complex.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:12553879, ECO:0000269|PubMed:15031412}.
Interaction partners:
- Dihydroxy-acid dehydratase, chloroplastic
- Fe-S cluster assembly factor HCF101, chloroplastic
- Bifunctional monothiol glutaredoxin-S16, chloroplastic
- Monothiol glutaredoxin-S14, chloroplastic
- Iron-sulfur assembly protein IscA, chloroplastic
- Cysteine desulfurase, mitochondrial
- Iron-sulfur cluster co-chaperone protein HscB homolog
- Iron-sulfur cluster assembly protein 1
- CDK5RAP1-like protein
- Threonylcarbamoyladenosine tRNA methylthiotransferase
Sequence:
MQLLTLNPAAISRTPPQAIDPSSSSSLLLPFPQILSSQRALGLVARPCNPLRRGLSRFLSSRQLFRRSKVVKAVATPDPILEVPLTEENVESVLDEIRPYLMSDGGNVALHEIDGNIVRVKLQGACGSCPSSTMTMKMGIERRLMEKIPEIVAVEALPDEETGLELNEENIEKVLEEIRPYLIGTADGSLDLVEIEDPIVKIRITGPAAGVMTVRVAVTQKLREKIPSIAAVQLI