wanglab/gogpt-training-data huggingface dataset:
Protein: Alginate biosynthesis protein AlgK (P96956)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: May be involved in the polymerization of mannuronate to alginate.
Subcellular location: Cell outer membrane {ECO:0000305|PubMed:21713511, ECO:0000305|PubMed:9457868}; Lipid-anchor {ECO:0000305|PubMed:21713511, ECO:0000305|PubMed:9457868}; Periplasmic side {ECO:0000305|PubMed:21713511, ECO:0000305|PubMed:9457868}.
Interaction partners:
- Alginate lyase
- Mannuronan C5-epimerase
- Alginate biosynthesis protein AlgX
- Mannuronan synthase
- Alginate production protein AlgE
- Mannuronan synthase
- Probable alginate O-acetylase AlgJ
- GDP-mannose 6-dehydrogenase
- Probable alginate O-acetylase AlgI
- Alginate biosynthesis protein AlgA
Sequence:
MKMPILPPLPLASRHLLLASAIALAAGCAGLPDQRLAQEALERGDLATAQSNYQALAAMGYADAQVGLADMQVASGDSAQQAKAEKLYREAAQTSPRARARLGKWLAAKPGASDAEHREAERLLSQAFEQGEDSALVPLIVLYLQYPQSWPEIDPQQRIDQWRARGLPQADLAQIILYRTQGTYAQHLGEIEQVCQRWLRRMDVCWYELATVYQMQGNAEKQKVLLEQLRAAYKAGRVPGERVDSVAGVLADGELGQPDPQTAQALLEEIAPSYPAAWVSLAKLLYDYPDQGDLEKMLGYLKNAQDAAQPRAELLLGRLYYDGKWAPQDPRKAERHLLKAAASEPQANYYLGQIYRRGFLGKVYPQKAVDHLILAARAGQASADMALAQLWSQGRGIQPNRVNAYVFGQLAVQQQVPQASDLLGQIEAQLPPAERSQAQQLLKREQQSRGNNWQATVSLLQSQDSPINEEEPESL
Protein: Cullin-1 (Q94AH6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Regulator of mitotic processes which plays a role during gametogenesis and embryogenesis. Together with SKP1, RBX1 and a F-box protein, it forms a SCF complex. The functional specificity of this complex depends of the type of F-box protein. SCF(UFO) is implicated in floral organ development. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1/ZTL), SCF(ADO2/LKP2), SCF(ADO3/FKF1) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling.
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Mainly nuclear during interphase and preprophase, but also weakly cytoplasmic during interphase. Associated to mitotic spindle during metaphase, and to the phragmoplast during telophase.
Interaction partners:
- SKP1-like protein 13
- SKP1-like protein 17
- SKP1-like protein 3
- SKP1-like protein 10
- SKP1-like protein 9
- SKP1-like protein 19
- SKP1-like protein 5
- SKP1-like protein 14
- SKP1-like protein 18
- SKP1-like protein 11
Sequence:
MERKTIDLEQGWDYMQTGITKLKRILEGLNEPAFDSEQYMMLYTTIYNMCTQKPPHDYSQQLYDKYREAFEEYINSTVLPALREKHDEFMLRELFKRWSNHKVMVRWLSRFFYYLDRYFIARRSLPPLNEVGLTCFRDLVYNELHSKVKQAVIALVDKEREGEQIDRALLKNVLDIYVEIGMGQMERYEEDFESFMLQDTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERERVAHYLHSSSEPKLVEKVQHELLVVFASQLLEKEHSGCRALLRDDKVDDLSRMYRLYHKILRGLEPVANIFKQHVTAEGNALVQQAEDTATNQVANTASVQEQVLIRKVIELHDKYMVYVTECFQNHTLFHKALKEAFEIFCNKTVAGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDRSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLARENQNSFEDYLGSNPAANPGIDLTVTVLTTGFWPSYKSFDINLPSEMIKCVEVFKGFYETKTKHRKLTWIYSLGTCHINGKFDQKAIELIVSTYQAAVLLLFNTTDKLSYTEILAQLNLSHEDLVRLLHSLSCAKYKILLKEPNTKTVSQNDAFEFNSKFTDRMRRIKIPLPPVDERKKVVEDVDKDRRYAIDAAIVRIMKSRKVLGHQQLVSECVEQLSRMFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYLA
Protein: DUF2921 family protein, putative (DUF2921) (Q9SVS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ran-binding protein 1 homolog a
- Ras-related protein RABA2b
- Secretory carrier-associated membrane protein 1
- Probable galacturonosyltransferase 10
- Chloride channel protein CLC-d
- Protein YIP
- Probable methyltransferase PMT18
- Probable methyltransferase PMT12
- Syntaxin-42
- Copper-transporting ATPase RAN1
Sequence:
MATFWPSSSSSNHPSIFLYLQSYPSLFFLLFLTTSATSLTVASLVNPHSFIAPRIPYSDHCNHIVPESPIDPSPSAVFSHASLAFDVSFFSGGDLFFNRFQSQNGDVKSARFRPKSIRKTLGDGKIYKVEAKLTLQISKTSASSSYYGGDFGQKKLQVMQIDGRSSWGGASFDFYGFWSESTGQVCMVGSTQVLSVEGTRLKIFDARLMLNYSKESNIYGSLVKGVLESVDSLSEFKTVLILGARNTPLNYEYKLLEQSKLDCGVNGGESLSLENVLGGMCKVFEGRSHVFGLMYRNDCGVDHSCSPFGSDVEYTPGFMSMLSFLCDGEKMRMLLSFSNMSGYSSLFPFDPRTSLVAEGSWDVERNRFCGVACRILNFSDSLSNAVVDDCSLRLSLRFPAILSIKSMAPVVGELWSAQAESDPSYFRRIEFSSLNDQLWRFPSLRYEYTESERVGKLCGAGKSRPKRKGNHYPDAQTSDMRFVMSVKYSGEGNVLRTARASPYFVGDRLYRDLLVRGQGVGLTGIPMNVNSVTKSFTNITYRIRSLNPNSESRGDIYAEGTYDRDTGELCMVGCQSVRLKNTVAIQNETVDCSLAIKINFSPIDSRSDDRLKGTIKSTREKTDPLYVGRMEVLSRSIYVHQAKESVWRMDLEVAMVLVSNTLSCLFLGMQLYHMKQHQEALPFISVAMLILITLGHMIPLLLNFEELFKGSHNQRNLFFENDRWLEAKEIVVRIVTLIAFLLECRLLQLAWTARKTGDHHHREDVWKAEKKVSYVCLPLYITGGLIAWLVNRNRTPKRIVYIGKPQARNLLYRPVNLKRSFQRPPLWKDLKSYGGLMLDAFLLPQILFNGFSNSDLKPLAALFYVGNSFVRLLPHAYDLYRSHSYGKILDWSFIYANHKMDYYSTAWDIIILCIGFLFAFLIFLQQRFGGRCFIPKRFREYVGYEKVVELQQAGEQHNTNDS
Protein: Beta-hexosaminidase (EC 3.2.1.52) (H3BP20)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
Sequence:
MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGWPHQAYPVFLGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
Protein: Cytochrome c oxidase subunit 4, mitochondrial (Cytochrome c oxidase polypeptide IV) (P79010)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P04037}; Peripheral membrane protein {ECO:0000250|UniProtKB:P04037}; Matrix side {ECO:0000250|UniProtKB:P04037}.
Interaction partners:
- Cytochrome c oxidase subunit 12, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 7
- Cytochrome c oxidase subunit 13, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b-c1 complex subunit 9
Sequence:
MFMNSMLRVSRQRAAVRSTVSLYRGFVSASIRRNEQNVVKAAAQELANAKEPSDLIGPGGRDGEVPTDLEQATGLERYELLSELSGRDAFDMKPLDASRKGTLTDPIMVTSLDPYRHIGCTGSPSGSHNLIWMTVYKDKLRRCPECGSVYKLKFMGDPNAEHSH
Protein: GPI ethanolamine phosphate transferase 2 (F4IJJ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- At1g16040
- Haloacid dehalogenase-like hydrolase domain-containing protein Sgpp
- Transcription factor ALC
- Phytol kinase 1, chloroplastic
- Homogentisate solanesyltransferase, chloroplastic
- GPI inositol-deacylase
- 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase, chloroplastic
- Tocopherol O-methyltransferase, chloroplastic
- Transmembrane emp24 domain-containing protein p24delta7
- Emp24/gp25L/p24 family/GOLD family protein
Sequence:
MTTAAMTCTRLTIFTVAGILLQIIGLSIFVFGFFPVKPTLSGVSGSESYRDPFCDSSLISNESELHHPEKLRLLYQELSGISSKYDRLILMVIDGLPAEFVLGKDGKPPEKVLKESMPYTQSLLANGDAIGYHAKAAPPTVTMPRLKAMVSGAIGGFLDVAFNFNTQALLDDNILGQFFRIGWKMVMLGDETWLKLFPGLFMRHDGVSSFFVKDTVQVDRNVSRHLPDELNSDDWNLLILHYLGLDHVGHTGGRNSPLMPAKLKEMDDIVRTMHLRAMMDRSHDQGQTLLIIVSDHGMTENGNHGGSSYEETDSLMLFIGLNSNISDYASATNNVAFQVDLAPTLALLFGVPIPKNNVGVLVPGTLCSLRDFEQLRALELNSWQLLRLMLAQIQSSSFPRVSCNCFLDGTCEGLDLDISECSGDKEKQLICLFRNAAALHGIWKSKKSTESSSTMEDFSRALDAYNTFLKTASEWLASKTTEKPVLLLGLGVSAMLLSCFICGTVFLSLFKEVYHEPKDRVCSLSNLLNLEEVFIFALLLILVISMGSSSMVEEEHYIWHFMVSTFHLLLLFKTAKSFKISKGMNILRDFKFGSIFSLLISGRLLRGWHQGGVNWTYLPDISKWLVQGGSGYVKWIQLISIILVIGLGLYTLFRTGSNRKGVRILAFGFSTCGFLVLLHVGRYQDELSTGFGATVTVKVIYYLLSISSIGASLVLPWSALNKDKSFLAEVGDCLYLIGSAYILCWCLLQQLLQQPINSGPILLLLLQILAILCLSSSDFQVNEWVEITALYYMGMAGHFALGNSNTLATIDVAGAFIGISSHSTILSGILMFMITYASPMLFLLSLVMYIGANLRNHSNSTISTHRETSLGQILKLKLGFPCLVPLCINSILLTAYTVVLLLMRNHLFVWSVFSPKYLYVCATTLCTYIGVCIVAATVTYTFYVTTFLRSNRTRHNNS
Protein: Alpha1,4-galactosyltransferase 2 (Q9VBL5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Interaction partners:
- Alpha1,4-galactosyltransferase 1
- Alpha-galactosidase
- beta-N-acetylhexosaminidase
- beta-N-acetylhexosaminidase
- Beta-galactosidase
- Beta galactosidase, isoform A
- Uncharacterized protein, isoform A
Sequence:
MKVSRTLIVVGSLLLILSIVLTYKWIAYNHAYPKAQTELTNSTKKANLIDSKAKNKKHVQNSLAKKAAKSVANQSKFKLDKVSKKIPVIPLLDVLKAKKQPSRGQNIFFHETTNFKRIEKSSVVQLTAREACAIESAALHNPGLTVFVLFAGATHRPSSGDPLIRALHNYKNIRLRHLNLWRYAAGTPIAKWLKSGKLFKSKFLFPHVSDLLRYVSLYKYGGLYLDLDVVVQQNLEKLPPNFTGAESNISVACGVMKMSPGGLGHKIATMCLRDLEANYNANKWGTNGPGVITRVVKKQCNTDNIKSVINNPKRCNGFKVFDANAFYAISWLQWKDFFQPNRHNVTMKRVSKSPVIHVWNKFSKGWKVKTKSNCAYTTLAKIHCPRSFAAAGELF
Protein: DNA gyrase subunit B (EC 5.6.2.2) (P0C559)
Organism: Mycolicibacterium smegmatis (Mycobacterium smegmatis)
Function: Supercoils relaxed DNA in an ATP-dependent manner. A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes. At comparable concentrations has a stronger decatenation activity than E.coli, which is inhibited by ciprofloxacin and novobiocin. Cleaves dsDNA at the sequence 5'-AT/GGCC-3', leaving a 4 base overhang. Relaxes negatively supercoiled DNA in an ATP-independent manner.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12000834}.
Interaction partners:
Sequence:
MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGFATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGLHGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIFETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEATGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISVKVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHISTLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKKINVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARRSFITRNAKDVRFLDV
Protein: Bcl-2-binding component 3 (p53 up-regulated modulator of apoptosis) (Q99ML1)
Organism: Mus musculus (Mouse)
Function: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (By similarity). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (By similarity). Regulates ER stress-induced neuronal apoptosis.
Subcellular location: Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. {ECO:0000250}.
Interaction partners:
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
- Phorbol-12-myristate-13-acetate-induced protein 1
- Bcl-2-related protein A1
- Bcl-2-like protein 11
- BH3-interacting domain death agonist
- Bcl-2-like protein 2
- Bcl-2 homologous antagonist/killer
- Apoptosis regulator BAX
Sequence:
MARARQEGSSPEPVEGLARDSPRPFPLGRLMPSAVSCSLCEPGLPAAPAAPALLPAAYLCAPTAPPAVTAALGGPRWPGGHRSRPRGPRPDGPQPSLSPAQQHLESPVPSAPEALAGGPTQAAPGVRVEEEEWAREIGAQLRRMADDLNAQYERRRQEEQHRHRPSPWRVMYNLFMGLLPLPRDPGAPEMEPN
Protein: Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) (Q9BSM1)
Organism: Homo sapiens (Human)
Function: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:21282530}.
Interaction partners:
- YY1-associated factor 2
- E3 ubiquitin-protein ligase RING2
- E3 ubiquitin-protein ligase RING1
- BCL-6 corepressor
- RING1 and YY1-binding protein
- Lysine-specific demethylase 2B
- S-phase kinase-associated protein 1
- BCL-6 corepressor-like protein 1
- Chromobox protein homolog 2
- Chromobox protein homolog 8
Sequence:
MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSRWFGKPSPLLLQYSVKEKRR
Protein: Calponin (Q6PBA5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSSQFNRGPAYGFSAEVKSKIAQKYDPQREEELRIWIENTTGRSIGDDFQKGLKNGVILCELINKLQPGSVKKINQSSQNWHQLENLTNFIKAITTYGLKPHDIFEANDLFENGNMTQVQTTLLALAGMAKTKGIHSSVDIGVKYAERQERAFDDEKMKAGQCVIGLQMGTNKCASQAGMNAYGTRRHLYYPKSHILPPMDHSTISLQMGTNKGASQAGMTAPGTRRAIYDQKTGTDKCDNSTMSLQMGYSQGANQSGQNFGLGRQIYDAKYCPKGGAVAAGEGNDGQYTDYQDEGYQGYQDDGQDY
Protein: Ankyrin 2 (H0Y8Y2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEVTLCEPSILSSTSQFQAEPVEGRRVSKVVKTTVVLGERMEKHLGDSSLATDLPSAKDDFEEDNNE
Protein: Cheilanthifoline synthase (CHS) (EC 1.14.19.65) (Cytochrome P450 719A14) (B1NF20)
Organism: Argemone mexicana (Mexican prickly poppy)
Function: Methylenedioxy bridge-forming cytochrome P450 involved in the biosynthesis of isoquinoline alkaloids. Converts (S)-scoulerine into (S)-cheilanthifoline, a precursor of sanguinarine. Catalyzes an oxidative reaction that does not incorporate oxygen into the product.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDETIWLIISTVIIVLGIAKFLLGKSSSSSLSTMEWPVGPKKLPIIGNLHQLGGDVFHVVLANLAKVYGSVFTIWVGSWRPMIIVSDIDKAWEVLVNKSSDYSARDMPDITKIISANWKNISCSDSGPFWHNLRKGLQGVALTPLNVASQYHLQERDMKNLINSMYKDASRKNGILKPLDYLKEETVRLLSRLIFGQDFQDEKLVVGMHHALDDLVRISGYASLADAFKFCENLPSHKKSIREVHEVKKRVENLIRPHIVSNPPTNTYLYFLKTQDFNEDIIISAILEVYDLGVDSTASTTVWALTFLVREQEIQEKLYREIVNVTGGKRSVKVEDVNKMPYLQAVMKETMRMKPIAPMAIPHKTSKDTSLMGKKINKGSVIMVNLYAIHHNPKVFPEPYKFMPERFLKDVNSDESLGNIKTMESSLLAFSAGMRICAGMELGKLQLAFGLASLVHEFKWSCSVDGKLPDLSEDHCFILLMKNPLEAKITCRIH
Protein: Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45) (Q5JXC2)
Organism: Homo sapiens (Human)
Function: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.
Interaction partners:
- Insulin-like growth factor-binding protein 2
Sequence:
MVEAEELAQLRLLNLELLRQLWVGQDAVRRSVARAASESSLESSSSYNSETPSTPETSSTSLSTSCPRGRSSVWGPPDACRGDLRDVARSGVASLPPAKCQHQESLGRPRPHSAPSLGTSSLRDPEPSGRLGDPGPQEAQTPRSILAQQSKLSKPRVTFSEESAVPKRSWRLRPYLGYDWIAGSLDTSSSITSQPEAFFSKLQEFRETNKEECICSHPEPQLPGLRESSGSGVEEDHECVYCYRVNRRLFPVPVDPGTPCRLCRTPRDQQGPGTLAQPAHVRVSIPLSILEPPHRYHIHRRKSFDASDTLALPRHCLLGWDIFPPKSEKSSAPRNLDLWSSVSAEAQHQKLSGTSSPFHPASPMQMLPPTPTWSVPQVPRPHVPRQKP
Protein: FI24319p1 (Mst89B) (Q9VEX4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH16156p
- FI21290p1
- IP09407p
- Dynein light chain 2, cytoplasmic
- Uncharacterized protein, isoform A
- Galectin
- Uncharacterized protein, isoform E
- inositol-phosphate phosphatase
Sequence:
MANNFNTRKVMQVAEEGAPPVHIPIMVGNEIIVLTQQDIRRVEDTRVISYSRVGPNGQFLPLDTSSPGAVYFPPPNTTHFCTLDDLLRNASDKRETSNPLKTVASVSTQLVWSKKKSGSEHRLPLCYDAGTSTSGLMTNTGCQHCPKCETQHSSCQTQMFAKTQTTVEREMPRNASCQTKDTATPTRTSIVKAPQNVGCQTQSCLSENTYMKNEPANSRCQAQRNTNSTGCGTYSDLFETTSAESYTSAECDYTSSVESTCQHCKSQPTCTDQTLIVPMQPQVQSPVPPQEQPCTSRHIRFDLCTQVNNFEPHVEPHFYRTIPLGQNPYPRAQVSKPSVSKHTGWTNLNPDHEILQQELSQNASISKHQ
Protein: Tumor protein 63 (p63) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (Q9JJP6)
Organism: Rattus norvegicus (Rat)
Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Tumor protein p73
- Keratin, type II cytoskeletal 5
- Cellular tumor antigen p53
- Protein phosphatase 1, regulatory subunit 13B
- Protein phosphatase 1, regulatory subunit 13 like
- E3 ubiquitin-protein ligase Mdm2
- Tumor protein p53 binding protein, 2
- SRY-box transcription factor 2
- Keratin, type I cytoskeletal 14
- Uteroglobin
Sequence:
MNFETSRCATLQYCPDPYIQRFIETPSHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNGMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE
Protein: Nucleoporin NUP37 (Nuclear pore protein NUP37) (G0S2X1)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q8NFH4}.
Interaction partners:
- Nucleoporin NUP120
- Protein ELYS
Sequence:
MALQPVPRMRRTLQNTQHTYSLGRRIYDVKTYPVQSPQGATILIYGHENGATVVWRGGRRLKPPKPQTNEKRNGTKPEDAVMIIDSDDETGPTFVDKPEFEDSPSVADGSVAEIIQTLDLALGTAVNHIAVLPMPPCAAEDASWNGANILKTKIVFAVTCATNDVYVITLPLTPPSHEAKARPELRKSLLAGNAGKGVWGETLTLLTGPSRSCNGVAISLVKHRSSSRSRSSERSAAQAAPITRVVVAAHSREASGTLRLWDVPLEAKPGTINRVEPFQTEYLPSPLTSISFNPVNLTQLLTVASPHAVRIYDYATASLPSDDTSEGPFPSQGSWLISLYPPFARGPAMSTSRKPIVAAEWIARGRAILTLLADGQWGIWDLDGASPTAAGGGSNLFSKTSAGLRGTAITAFSVTGHLEGTSPLRNPTTQKASSSSSGEFVPMTPHTRRDAIATAFGGSPEKLAAVRGGITVAQLPSTLTSGAGDESAVLFLGGADPIVCVIPVLSKFWDSQLRRAAGGGVNLWSGAQPTRMIRLTDLSAGLLGERCTGAVAITKAVRANASTNGILKEDDNSGSQGLPIEVLLQGESRLVIVHENGDAPTSSLTSRLLGARKKQRDEFKSVNAIVAYPPLEKPSVSFNLNLTQRPEKPGTLFAPRSRHSKSLFEQSIDTIPSTDAGDEETIPATSAPSSQQGFMFATDLELAADLPDDEADAEGRDVEQELLDIMEIDRELEQLEQARERGRKRVFFEEG