wanglab/gogpt-training-data huggingface dataset:
Protein: Glycogen phosphorylase (EC 2.4.1.1) (P06738)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:24146988, ECO:0000269|PubMed:38832010}.
Interaction partners:
- Glycogen debranching enzyme
- 1,4-alpha-glucan-branching enzyme
- Phosphoglucomutase 2
- Glucoamylase, intracellular sporulation-specific
- Phosphoglucomutase 1
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogen [starch] synthase isoform 2
- Glycogen [starch] synthase isoform 1
- Probable UTP--glucose-1-phosphate uridylyltransferase
- Phosphoribomutase
Sequence:
MPPASTSTTNDMITEEPTSPHQIPRLTRRLTGFLPQEIKSIDTMIPLKSRALWNKHQVKKFNKAEDFQDRFIDHVETTLARSLYNCDDMAAYEAASMSIRDNLVIDWNKTQQKFTTRDPKRVYYLSLEFLMGRALDNALINMKIEDPEDPAASKGKPREMIKGALDDLGFKLEDVLDQEPDAGLGNGGLGRLAACFVDSMATEGIPAWGYGLRYEYGIFAQKIIDGYQVETPDYWLNSGNPWEIERNEVQIPVTFYGYVDRPEGGKTTLSASQWIGGERVLAVAYDFPVPGFKTSNVNNLRLWQARPTTEFDFAKFNNGDYKNSVAQQQRAESITAVLYPNDNFAQGKELRLKQQYFWCAASLHDILRRFKKSKRPWTEFPDQVAIQLNDTHPTLAIVELQRVLVDLEKLDWHEAWDIVTKTFAYTNHTVMQEALEKWPVGLFGHLLPRHLEIIYDINWFFLQDVAKKFPKDVDLLSRISIIEENSPERQIRMAFLAIVGSHKVNGVAELHSELIKTTIFKDFVKFYGPSKFVNVTNGITPRRWLKQANPSLAKLISETLNDPTEEYLLDMAKLTQLGKYVEDKEFLKKWNQVKLNNKIRLVDLIKKENDGVDIINREYLDDTLFDMQVKRIHEYKRQQLNVFGIIYRYLAMKNMLKNGASIEEVAKKYPRKVSIFGGKSAPGYYMAKLIIKLINCVADIVNNDESIEHLLKVVFVADYNVSKAEIIIPASDLSEHISTAGTEASGTSNMKFVMNGGLIIGTVDGANVEITREIGEDNVFLFGNLSENVEELRYNHQYHPQDLPSSLDSVLSYIESGQFSPENPNEFKPLVDSIKYHGDYYLVSDDFESYLATHELVDQEFHNQRSEWLKKSVLSVANVGFFSSDRCIEEYSDTIWNVEPVT
Protein: fructose-bisphosphatase (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase) (Q9FMF1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Glucose-6-phosphate isomerase, cytosolic
- transaldolase
- Aldolase-type TIM barrel family protein
- Transketolase-1, chloroplastic
- Transketolase-2, chloroplastic
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
- Glucose-6-phosphate isomerase 1, chloroplastic
- Hexokinase-4
- Probable hexokinase-like 2 protein
- Hexokinase-1
Sequence:
MQSLTLTRYPTPISPPRLNLYPLRQIAASVLSAPTAGINRRDMASRHQSTSFKPLAVGRNLTGDDDDGYCTLIDFAGSGGGEGKNVGEDLVVLLYHLQHACKRIASLVASPFNSSLGKLSVNSSSGSDRDAPKPLDIVSNDIVLSSLRNSGKVAVMASEENDSPTWIKDDGPYVVVVDPLDGSRNIDASIPTGTIFGIYNRLVELDHLPVEEKAELNSLQRGSRLVASGYVLYSSATIFCVTLGSGTHAFTLDHSTGEFVLTHQNIKIPTRGQIYSVNDARYFDWPEGLRKYIDTVRQGKGQNPKKYSARYICSLVADLHRTLLYGGVAMNPRDHLRLVYEGNPLAFLVEQAGGKSSDGKRGILSIQPVKLHQRLPLFLGSLEDVAELESYGDVQQTVNPGYEV
Protein: THAP domain-containing protein 2 (Q9H0W7)
Organism: Homo sapiens (Human)
Interaction partners:
- THAP domain-containing protein 11
- Host cell factor 1
- Host cell factor 2
Sequence:
MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEANSVLPKGTSEHMLPTALSSLPLEDFKILEQDQQDKTLLSLNLKQTKSTFI
Protein: GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed] (P32883)
Organism: Mus musculus (Mouse)
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P01116}; Lipid-anchor {ECO:0000250|UniProtKB:P01116}; Cytoplasmic side {ECO:0000250|UniProtKB:P01116}. Endomembrane system {ECO:0000250|UniProtKB:P01116}. Cytoplasm {ECO:0000250|UniProtKB:P01116}.; SUBCELLULAR LOCATION: [Isoform 2B]: Cell membrane {ECO:0000250|UniProtKB:P01116}; Lipid-anchor {ECO:0000250|UniProtKB:P01116}.
Interaction partners:
- Son of sevenless homolog 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Afadin
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- RAF proto-oncogene serine/threonine-protein kinase
- Ral guanine nucleotide dissociation stimulator
- Zinc fingers and homeoboxes protein 2
- Serine/threonine-protein kinase A-Raf
- Leucine-rich repeat protein SHOC-2
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQELARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCVIM
Protein: Clusterin (Q6PTX2)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
AGSKYIDTEVENAINGVKQMKTLMDKTSKEHQAMLHTLEETKRRKEEAVKLALEKEKQLAEKQEVCNET
Protein: RE05635p (Q6AWL3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEEISSLDSFGADSNARPESATPRSEEQQDQDRQQTAPAASETLDTPASPPAEDAAAQESKPPPSKEADDDFEQISEGSLDADDNQSRDKAASTPADPVDAEEPAEEPTPNEEPQGGEDEQPQTEAVRVDPQEEPEEAEEETDALQATAEEVEAAAAEADAVDGGPASPEAVDVDEGEVDAEGEAEQEAEDDAALDREATDDVDMQSVGADSHQAEDAEPPEGRDEVDTSLEEQENGQDPDEREKDAAADEDDPDAEGDAESEQVDENAEETGEAEHGDDTVENVLEPEESDVCLIPDDQETEVTEAEKELARENAEKAAEEEEAEERQAKTPDNDRKSPADAAADPEDDSAAAVDATDVSPTTPTADGVAAAANEEEAGGDVPDPDEPTAEESSSAGAGEPGSTPKIIISWIVGSVQKCKQCGDEKNCGFRYRSPEESEEMDKEKENDKAEENAEEGEEEEARQKPAAPSGFEYICDTACVDALLEDQPGKYFVRRKKFLVEEVVREEGAAEAEASADGEGGDAEEEATPANTQDCLQCKDKTRCKYFIKQDQDCFYICNDDCFNLLNAEEPDKFKLKRHSIRVRNIGATTLQPPQNSPTKRTDGSVVARTVEEAETARLDRIESFRRRCADCEADINTDEKQLMWETMDFCNEVCLGSYQRTIGSTCETCKQEVSSIALGKYCVRFGFDVRQFCCAGCLNTFKKGLKTCSCCQKDISGGQEGFLAPVGDKDQFKDFCSQSCLRRYESMCNPRRKLRTDVCGVCNNQKPVRVEMLLEDREHYFCSNPCFSAFKFVSNVNADPCAMCSKYFERRSAESYTIYNEQQSPKVFCSRVCINVYIIVNRHIVSCQWCKVKKYNFDMIYQIGGPHDQETLTCSINCLTMHGVSCNISARAVTKCDNCSNFNTPQYHLTMSDASMRNFCTYQCVMQFQNQFARAPLTLDSDLPPSSAGSSKSQQQSNRGNKNAAPFPTGLPKRVKLKLSHTGKGGVGGKKSGSGTMLPVISTVQSLASGETEARIGNLTVRRKRGRPRESGTSSPPLSMPGVHPPAQRGRPRKHAVDYSARSPSPTMSGGSSHMGIPVRRNTTTTMDFGPATVTETKIITVPPYPKAVRNVNISCKPLTVTQGEQCSPDVRDCATQTEKDYSNKVLIPVPVPIFVPQPMYMYSAPFPVPVPIPLPIPVPIFIPTTRNTAQGILKEIKKIQDKMPEDPLEAELLMMAEMVAEEKHESDSDSDNEIKPDPGLVALQYQNSLESVAQQQQQQQVVDVSGAGHNPYGDDMLQIALKMATGDYDNHHQTSTVDLETSMTANTISSQSPMGHDGMGQMGVHHLDQQHHMLDATQRTARGRKRGVGVVMDPPNRNSRSPVKRQRGGEMDHSALQQQSQQAQQPQEKPDAQMFLKYTFGVNAWKQWVMTKNADIEKSSMRRRPFKTELLQMTADELNYSLCLFVKEVRKPNGTEYAPDTIYYLVLGIQQYLYVNGRIDNIFYDPYYERFTECLDEVARKFSVLYNDSQYIVTRVEEEHLWECKQLGAHSPHVLLSTLMFFNTKHFNLTTVEEHMQLSFSHIMKHWKRSSQNSKVPGSRNVLLRFYPPQAGLDANPRKKKVYEQQENEENPLRCPVRLYEFYLSKCPESVKTRNDVFYLQPERSCVPDSPVWYSTQALGQDALQRMLHRVKMVKEINIALLTT
Protein: Interferon alpha-14 (IFN-alpha-14) (Interferon alpha-H) (LeIF H) (Interferon lambda-2-H) (P01570)
Organism: Homo sapiens (Human)
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular location: Secreted.
Interaction partners:
- Interferon alpha/beta receptor 1
- Interferon alpha-21
- Interferon alpha-5
- Ubiquitin-like protein ISG15
- Interferon alpha-16
- Interferon alpha-6
- Interferon alpha-1/13
- Antiviral innate immune response effector IFIT1
- Interferon-induced protein with tetratricopeptide repeats 3
- Interferon alpha-7
Sequence:
MALPFALMMALVVLSCKSSCSLGCNLSQTHSLNNRRTLMLMAQMRRISPFSCLKDRHDFEFPQEEFDGNQFQKAQAISVLHEMMQQTFNLFSTKNSSAAWDETLLEKFYIELFQQMNDLEACVIQEVGVEETPLMNEDSILAVKKYFQRITLYLMEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD
Protein: Kinetochore protein spc25 (Q10430)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:15728720}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15728720, ECO:0000269|PubMed:16823372}. Note=Associated with kinetochores. {ECO:0000250|UniProtKB:P40014}.
Interaction partners:
- Kinetochore protein nuf2
- Kinetochore protein ndc80
- Kinetochore protein spc24
- Kinetochore protein mis13
- Outer kinetochore KNL1 complex subunit spc7
- Kinetochore protein nnf1
- Kinetochore protein mis14
- Centromere protein mis12
- Monopolin complex subunit pcs1
- Monopolin complex subunit mde4
Sequence:
MSLANFPTIELDYDSLKSKISNFNSIFDRFLQEERKKLLNNKNEYLRQLSEINEAQKKAEKSLEQTEARKQNFTELLEKEHEEQAITEQEIFSFQEKLDAMLKRKQKLSEELDHYRAIISSKRELRAQEMEAKRKQDSYNNPELKFWEDYLGLKMEGVHDEVIRFIFTNIDEKDWNKQFSFQINLAERDYKVVHCHPPLPHVDDLVNKVNRTRDFYQFLKDMRKGFRELHRKDLSQLI
Protein: Protein FAM234A (Protein ITFG3) (Q9H0X4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLDHKDLEAEIHPLKNEERKSQENLGNPSKNEDNVKSAPPQSRLSRCRAAAFFLSLFLCLFVVFVVSFVIPCPDRPASQRMWRIDYSAAVIYDFLAVDDINGDRIQDVLFLYKNTNSSNNFSRSCVDEGFSSPCTFAAAVSGANGSTLWERPVAQDVALVECAVPQPRGSEAPSACILVGRPSSFIAVNLFTGETLWNHSSSFSGNASILSPLLQVPDVDGDGAPDLLVLTQEREEVSGHLYSGSTGHQIGLRGSLGVDGESGFLLHVTRTGAHYILFPCASSLCGCSVKGLYEKVTGSGGPFKSDPHWESMLNATTRRMLSHSSGAVRYLMHVPGNAGADVLLVGSEAFVLLDGQELTPRWTPKAAHVLRKPIFGRYKPDTLAVAVENGTGTDRQILFLDLGTGAVLCSLALPSLPGGPLSASLPTADHRSAFFFWGLHELGSTSETETGEARHSLYMFHPTLPRVLLELANVSTHIVAFDAVLFEPSRHAAYILLTGPADSEAPGLVSVIKHKVRDLVPSSRVVRLGEGGPDSDQAIRDRFSRLRYQSEA
Protein: Photosystem II reaction center protein J (PSII-J) (Q2LIJ5)
Organism: Oryza punctata (Red rice)
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01305}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01305}.
Interaction partners:
Sequence:
MADTTGRIPLWLIGTVTGIAVIGLIGVFFYGSYSGLGSSL
Protein: Protein unzipped (Protein zipper) (P10379)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for normal axon patterning during neurogenesis.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Uncharacterized protein, isoform D
Sequence:
MTSNSCLISLGLLLVLIQILAPAKAAEHSVFTHKNASSVLGQLVTSSTLVWESYDPKDATQLQFAVEGGKYVTEDEHYPMYVCRVPIDGIQVSGHTEKILQRHVCLAAHYKHGKYDNFDVLMNKGHLGKVGWRHWRKFDAGVPVGAIRIGDDSYIGRHRAPSQPNKDGVVTHWGADFNLGHLEPVGLGKIRVIEAEREKYYDDGEVLVETEPFRYELRDIKLDRLRTDIQENMTELVTRKLENLEDKYSTVETILSYTFNYNQYWGSHEGVARGLPTKIFEKDEAVPAEINWALKHTEKRSENKAVHTKLWPGTAINVTLRGNYVTLEAPYSGKLFAFYYGSDESVSRKISAEVRKSYLKEVKLEFSPVYWIENGTLVPTTTTTTTTSTSTTTHATTTSTNEPTPINEPPLVHMKDNGVQHSGPDTLEKTLHDSPSSNELNSHEAPENMSSDPGKDVALAGFGVNAAGSTFIAGSALLTLLLTIFLSL
Protein: U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'') (P40567)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA.
Subcellular location: Nucleus.
Interaction partners:
- Pre-mRNA-splicing factor SYF1
- Protein HSH49
- Pre-mRNA-splicing factor CWC2
- Cold sensitive U2 snRNA suppressor 1
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor PRP46
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- Small nuclear ribonucleoprotein F
- Pre-mRNA-splicing helicase BRR2
Sequence:
MVEPARKKQRIDRDTHHTVAEPVTEAKNTLYVSQLNEKINMQRLRVNLFLLFATFGEVLKVSMNFKKQRGQAFITMRTIDQASLAQISLNGERFFGKPLKVEFSKSETKTL
Protein: hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) (D6XFK6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Methylglutaconyl-CoA hydratase, mitochondrial, putative
- Hydroxymethylglutaryl-CoA synthase
- propanoyl-CoA C-acyltransferase
- Succinyl-CoA:3-ketoacid-coenzyme A transferase
- Citrate synthase
- 3-oxoacyl-[acyl-carrier-protein] reductase
- Succinate--CoA ligase subunit beta, mitochondrial
- 3-methylcrotonyl-CoA carboxylase, putative
- Succinate--CoA ligase subunit alpha, mitochondrial
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Sequence:
MFRTLPLRSSIRMVECPRDAMQGLPHFIPTEQKIRYLKALLKCGFYALDCGSFVSPRAVPQMRDSTEVIANCWKTMQEEKAAPKLSVVVASLAGFKQALETPGVSVIGYPIGCCERFQQRNAKKSIAMSLDEIRNIKEATDAFNAQRSSNPVAPNEDVNGRELLIYISMAFGNPYGESHSIDLVEKLVGELVASGARDISLADTTGVAQPPLIFDTFTQLRKKFPDVTFAGHFHSNAVEARGKIVAALDAGCTMIDSALCGMGGCPFAKDDGLVGNVATEVVVKALEERGVLPAALNKEQLKKCVLIKQEIFGVSVRDMLISQTLHDEKRFATLCQEHFKLYDVNDDGTLDYEGFRDSMIHVFAELGAPQPSEEKIRSSFAKVDIQNLGFITIDAYTMGARRLLVKRLASNTNTTTKNEERGEGVVEASSC
Protein: Large ribosomal subunit protein eL21 (60S ribosomal protein L21) (P20280)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P46778}. Cytoplasm {ECO:0000250|UniProtKB:P46778}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P49666}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P46778, ECO:0000250|UniProtKB:P49666}.
Interaction partners:
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein eL24
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL32
Sequence:
MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIIVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVKENDQKKKEAKEKGTWVQLNGQPAPPREAHFVRTNGKEPELLEPIPYEFMA
Protein: Vesicle-fusing ATPase 2 (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein 2) (NEM-sensitive fusion protein 2) (Vesicular-fusion protein NSF2) (dNsf-2) (NSF-2) (P54351)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7642522}.
Interaction partners:
- Alpha-soluble NSF attachment protein
- Protein sly1 homolog
- Gamma-soluble NSF attachment protein
- Syntaxin-5
- Synaptobrevin
- Syntaxin-1A
- Gamma-soluble NSF attachment protein
- Secretory 22, isoform B
- LD27967p
- Neuronal synaptobrevin, isoform J
Sequence:
MSIEKAHRMRAIKCPTDELSLTNKAIVNVSDFTEEVKYVDISPGPGLHYIFALEKISGPELPLGHVGFSLVQRKWATLSINQEIDVRPYRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLTVGQTLVFQFKDKKFLGLAVKTLEAVDPRTVGDSLPKTRNVRFGRILGNTVVQFEKAENSVLNLQGRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRLIKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLARGIINWGPPVTELLEDGMLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDMVGFTESAKCLHIRKIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLTLQALLVLLKKQPPKGRKLLILCTSSRRDVLEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEELQSIARKMAGKRLCIGIKKLLALIDMIRQSEPHQRVIKFLSKMEEEGGLEMDRVQGH
Protein: Mitochondrial Rho GTPase (Miro) (dMiro) (EC 3.6.5.-) (Q8IMX7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Mitochondrial GTPase involved in mitochondrial trafficking. Forms an essential protein complex with Milt that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs). Also involved in the regulation of mitochondrial dynamics by promoting drp1-mediated mitochondrial fission during high calcium conditions, and negatively regulating fission during normal conditions.
Subcellular location: Mitochondrion outer membrane {ECO:0000305|PubMed:16055062}; Single-pass type IV membrane protein {ECO:0000305|PubMed:16055062}.
Interaction partners:
- Trafficking kinesin-binding protein milt
- E3 ubiquitin-protein ligase parkin
- Serine/threonine-protein kinase Pink1, mitochondrial
- Transmembrane GTPase Marf
- GTPase-GDP dissociation stimulator vimar
- Kinesin heavy chain
- Voltage-dependent anion-selective channel
- Transmembrane GTPase fzo
- LD30155p
- HDC05827
Sequence:
MGQYTASQRKNVRILLVGDAGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFSAVEQSEDALAAEINKAHVVCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAEAEGDTQREPIRKPIVLVGNKIDLIEYSTMDSVLAIMEDYPEIESCVECSAKSLHNISEMFYYAQKAVLHPTSPLYMMEEQELTSACKKSLVRIFKICDIDGDNLLNDYELNLFQRRCFNTPLQPQILDEVKAVIQKNVPDGIYNDAVTLKGFLFLHCLFIQRGRNETTWAVLRRFGYNDQLEMCQEYLRPPLKIPPGSSTELSHRGQQFLIAVFERYDRDGDGALSPEEHKMLFSTCPAAPWSYSTDIRKSCPINETTGWVTLHGWLCRWTLMTLIDVVKTMEYLAYLGFNVHENDSQLAAIHVTRERRIDLAKRQSSRSVYKCHVIGPKGSGKTGMCRGFLVEDMHKLIGKEFKTNVVNCINSVQVYGQEKHLILRDIDVRHALDPLQPQEVNCDVACLVYDSSNPRSFEYVARIYIKYYAESKIPVMIVGTKCDMDERRQDYLMQPSEFCDKYKLLPPHLFSLKTNKKELYTKLATMAAFPHLRQFGLMTEDPKLWLKAGLGVAAATMLGFIVLKTISAAGAHTR
Protein: DUF7087 domain-containing protein (Q9N431)
Organism: Caenorhabditis elegans
Interaction partners:
- PDZ domain-containing protein
- PH domain-containing protein
- DUF389 domain membrane protein
- Uncharacterized protein
- DUF7087 domain-containing protein
Sequence:
MDQIPPYEFNKYVLYVRGAVIVCASFELLLVLFGSLEDCNFLAKLFYFIFLGGAVAISAHNIGLNVDGREELNKVLSSSENEVRGKSAALILVPALSGVLVFLCVSGHAFFSLFVLIHVLAAVGQLGIEVYELKKGQSGGSARGAAPSAQDPAAAPPAQ
Protein: Rho guanine nucleotide exchange factor 3, isoform G (B7Z0H3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQLILSYLQSQQIKAVSSPTLSEPCLEEQPQKGTESTDVANTGSSAGSGGLGVLQKFKRTLNNFNNKNQLHISPLSPAAVGNNAPKTKTSPTTTTASIAPMITTTTASDPGSEAGDTSSGKYRFGPLIWRSSKERRKTKYNRRDKCNSGDSGIQIELEQDEQYSRATMAVSRQDEPRAFALTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNIGESDKAERKAPESLPTRSLSQPNGLESYGMGRPDLEDSDSDSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVEDILGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQNQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSETIARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRVVNVRDGKMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAKSTSRLCETLPKKSQSRDGISSAENSQIVTTTSTGSLGRRHFGNWFRKPKSANCTPSQSPTHKPSFDADATLTEARVAAMELAEAAAALVPTDSSSA
Protein: AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin) (Q9Y587)
Organism: Homo sapiens (Human)
Function: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:10436028}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- AP-4 complex subunit beta-1
- AP-4 complex subunit mu-1
- AP-4 complex subunit epsilon-1
- AP-2 complex subunit beta
- AP-5 complex subunit zeta-1
- AP-2 complex subunit alpha-1
- AP-5 complex subunit mu-1
- AP-5 complex subunit sigma-1
- AP-2 complex subunit mu
- AP-5 complex subunit beta-1
Sequence:
MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSES
Protein: POU domain protein (A0A0B4LEG2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MAEGCEDSAGAAESTTSQSQYTTLDKMLGTVLPCEAAIGATPGGGSSSGNSSSNIGGNTTNSSNNGSNIVKREFCDGSLMPGAGASVNNNNANAANNNNNNSSSSNNNNNNNNTKMQAMICNKSSSTNNSSSSSSSSSSCSSSSSSSSSATSTLTSCTTAAVVPSNCSTNANKSPVSPYSQSLGMAIGIGAGAGSSPLREASPLPSSRSPLNAIASTIAAKSPCSGAAPASPPSASSNSSSHVLALNIKTESDFDKEISCHKIHSPSSSSHAHSLHHHHHHHHHPHHSSRSNNNDDEMEITDGHALLSPPPPSHSHSHSPFDSKDHVKELEFYKNLAAKAASLANQHSPPPMPLPLPLPMQIDGEEDENEGEGEGEGEAEEQSAEVMRLRREEQAQAKAFAAHLNGTMQDMINLQKLQNLATLQQQQQQQQQHPHPHHGHQHHHHHPATAAALASLQGLAASVFNSPLNLSVGGEPVATTGPSVAPTSPTHNGGKSKTAKGGSSGNGSGGSSANSGTSSAQQQQQPDNPSSSSSPHHPLSASSLANVLAAATASPPPSLQAPPASAQMPQLILASGQLVQGVQGAQLLIPTAQGIAVQTILTIPVSPQIPTTEQFLPNAFGAFASYQQQQQQQQQQRDLLPPSLAALQHATALPQLAQTPTNLLKPNLFSTGVQQLLTALHPELFAAAAATHQQQQQQQQQQVQQQREREREREREREREREREREQHLGIGHLPHSHLAADLRRSAERSPTAGSPTGGSPGLAAKGPQPPPPGAAFLLQQQLHIKPETQTHLHHHLQTQSTSAVSSTLPQISLRHPDELTAPQMDLKPLELSASTSPPAPPPRHHFGHSLRGSSTVSPKHSPQGRMGGSGGSTTTGMNLSQHHERHDRLERLERQERHERRSHTPTATATRASVSSSSSAGHHGGSLPSGRLSPPSSAPSNSAANSISDRGYTSPLFRTHSPQGHALSLGGSPRLERDYLGNGPSSGTATSTSSCGAPTAAGSSATANVLSSINRLNASNGELTITKSLGAPTATATRASSASPRDDSPGPGPSTSSVSHMQPLKLSPSSRSEPPHLSPNGNDNDNDLLMDSPNEPTINQATTNVVDGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMKEAEESHWNRYKSGQNHLTDYIGVEPSKKRKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKNTVRMMSKGMV
Protein: Chromosome 19 open reading frame 40 isoform 1 (A0A0S2Z5V6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEKNPPDDTGPVHVPLGHIVANEKWRGSQLAQEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQPR
Protein: ARHGAP12 protein (Rho GTPase activating protein 12) (Q1RLN5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSKAFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPSSSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHFPGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTRDASISKGDFQNPGDQEWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTASSPKDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFGR