wanglab/gogpt-training-data huggingface dataset:
Protein: Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) (O60841)
Organism: Homo sapiens (Human)
Function: Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q05D44}.
Interaction partners:
- ATPase inhibitor, mitochondrial
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS12
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein RACK1
- Eukaryotic translation initiation factor 5
Sequence:
MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQLIVELKKVFEII
Protein: Rab3 interacting molecule, isoform W (A0A0B4K742)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRRKQDEVVTLEMQIRQRSEQQKKAGVELDATCHICLKTKFADGVGHICHYCNIRCCARCGGKVTLRSNKVIWVCILCRKKQELLSKTGQWINKTAAQQDGFIRRIEPDGSSDISQHPIVDPHDTTDKRPKLERTRSAAEKENLPMQRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNERDLLSSGGGGGGGVGGADFRHLSHATQRLYASADQRDRYELQLQHRERLEQYPLTRTARLDVQQRNSLNRSNHERQFSGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSSYYPQSKPQIVIGPGSGYDRGSGSMASMASAAAATAADAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPATSSSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKSLDAVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNTRLIGHMILRKYYDGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYGANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSSSPAGVHPHAHDHTSTTPSSLVGYVRDHQDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEPPSSDPAMCGECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSVLRLSRQLSEDALVAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTKSWGRRRIRYEDEVMPSSGDYPYPHSNPYSSYSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSHFLVTDDKIVTITYDSDVGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYLKRRRNLPHPPSAQNAHNFSPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHHNSQASSVSVSQSHNQQLQQQQQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGGTNANNASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQSQQQQLQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNNTNEPNATTTTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLSDTANDRKKGGGVDQERSPKGGSGMGKKSNSTSQLSATEQEQYQAQFAIAGSSTSSAGHHHITLPPPHPYHQRQSRGSAGSIQRSVEVPPVPPVTRYSAGSIHSITSSEGSSFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIASLDSLKL
Protein: Leucine-responsive regulatory protein [Lrp] (Q979L0)
Organism: Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Interaction partners:
- Dihydrodipicolinate synthase
Sequence:
MDEKDRDILNLLIDNSRISNTEIAKVLNVSEGTVRKRIKKMIDEGIIKRFTVETSDNTIDALILVKIDNKKYKEVLQRLRARYYEIYEFSGRIDVAIRIKTDSTDNLNRIVDQIREIEGVVDTDTLIRLQ
Protein: Interleukin-1 (O73909)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Lysosome {ECO:0000256|ARBA:ARBA00004371}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
Interaction partners:
- Uncharacterized protein
- Interleukin 1 receptor type 2.
- Interleukin 1 receptor accessory protein.
- Uncharacterized protein.
- Interleukin-6
- Interleukin-10
- Interferon gamma
- Myeloid differentiation primary response protein MyD88
- Interleukin-18
- Toll-like receptor 4
Sequence:
MAFVPDLDVLESSSLSEETFYGPSCLCLQKKPRLDSEHTTVDVQVTVRKGRGARSFRRAAVLVVAMTKLLRRPRSRDFADSDLSALLEEVFEPVTFQRLESSYAGAPAFRYTRSQSFDIFDINQKCFVLESPTQLVALHLQGPSSSQKVRLNIALYRPRGPRGSAGTGQMPVALGIKGYKLYMSCVMSGTEPTLQLEEADVMRDIDSVELTRFIFYRLDSPTEGTTRFESAAFPGWFICTSLQPRQPVGITNQPDQVNIATYKLSGR
Protein: Kunitz-type elastase inhibitor BrEI (P84881)
Organism: Bauhinia rufa (Orchid tree) (Pauletia rufa)
Function: Inhibitor of porcine pancreatic elastase with a Ki of 27 nM. Does not inhibit human neutrophil elastase, bovine trypsin, human plasma kallikrein or porcine pancreatic kallikrein.
Interaction partners:
Sequence:
ASPVLDANGDPLVPGGQYYVLPHIWPGPGGLSFEKTGNQTCPVSVFQLPRLPLEQNNGKPLVFTPVSETDDINEDTAVEIAFAEPPSCAESGKWLIVNDFKEEYWSVGIGGPQDHEGYQTLTGYFKIHKVGSFAYMFSFLPFVR
Protein: Tricin synthase 2 (EC 2.1.1.175) (Caffeoyl-CoA 3-O-methyltransferase ROMT17) (Q7F8T6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Catalyzes the stepwise methylation of tricetin to its 3'-mono- and 3',5'-dimethyl ethers. No 3',4',5'-trimethylated ester derivatives are produced. Can use caffeoyl CoA, 5-hydroxyferulic acid, luteolin, tricetin, quercetin, myrcetin and 7,8-dihydroxyflavone as substrates, but not naringenin, apigenin or kaempferol. The 2,3-double bond and the O-dihydroxyl group of the substrate are both required for catalytic activity of the enzyme.
Interaction partners:
- 4-coumarate--CoA ligase-like 9
- 4-coumarate--CoA ligase-like 2
- 4-coumarate--CoA ligase-like 3
- 4-coumarate--CoA ligase-like 1
- Os11g0205400 protein
- Hydroxycinnamoyltransferase 4
- Thymidine kinase
- Chalcone synthase 1
- Chalcone synthase 2
- Agmatine hydroxycinnamoyltransferase 1
Sequence:
MSMACTKVWRSTMYTPRRLKRTTPASRVSSTAMAAANGDASHGANGGIQIQSKEMKTAIHSNDSPKTLLKSESLHEYMLNTMVYPRENEFMRELRLITSEHTYGFMSSPPEEGQLLSLLLNLTGAKNTIEVGVFTGCSVLATALAIPDDGKVVAIDVSREYFDLGLPVIKKAGVAHKVDFREGAAMPILDNLLANEENEGKFDFAFVDADKGNYGEYHERLLRLVRAGGVLAYDNTLWGGSVALEDDSVLEEFDQDIRRSIVAFNAKIAGDPRVEAVQLPVSDGITLCRRLV
Protein: Probable lipase LipE (P72041)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible enoyl-CoA hydratase EchA21
- Lipase LipV
- GDSL-like esterase Rv1075c
Sequence:
MRAGDGKIRVPADLDAVTATGEEDHSEIDGAAVDRIWRAARHWYRAGMHPAIQLCIRHHGRVVLNRAIGHGWGNAPTDEADAEKIPVTTDTPFCVYSAAKAITATVVHMLVERGHFALDDRVCEYLPSYTSHGKHRTTIRHVLTHSAGVPFPTGPRPDVRRADDHEYAVERLGELRPLYRPGLVHIYHALTWGPLMREIVYAATGKEIREILATEILDPLGFRWTNFGVAERDVPLVAPSHATGRQLPPVIAAVFRKAIGGTVHEIIPYTNTPFFLSTILPSSNTVSTANELSRFMEILRRGGELDGVRVLSPETLRGAVTECRRLRPDFATGLMPLRWGTGFMLGSAKYGPFGRNAPAAFGHLGLVNIAVWADPERALSGGLISSGKPGRDPEAGRYGALLNAITAEIPRASSG
Protein: Alpha/beta hydrolase domain-containing protein 17C (Abhydrolase domain-containing protein 17C) (EC 3.1.2.22) (Q8VCV1)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95.
Subcellular location: Recycling endosome membrane {ECO:0000250|UniProtKB:B5DFK7}; Lipid-anchor {ECO:0000250|UniProtKB:B5DFK7}; Cytoplasmic side {ECO:0000250|UniProtKB:B5DFK7}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:B5DFK7}. Postsynaptic density membrane {ECO:0000250|UniProtKB:B5DFK7}.
Interaction partners:
Sequence:
MPEPGPRMNGFSLGELCWLFCCPPCPSRIAAKLAFLPPEPTYTVLAPEQRAPAPAATPAPAPAAQPAPAEEGAGPGACSLHLSERADWQYSQRELDAVEVFFSRTARDNRLGCMFVRCAPSSRYTLLFSHGNAVDLGQMCSFYIGLGSRINCNIFSYDYSGYGVSSGKPSEKNLYADIDAAWQALRTRYGVSPENIILYGQSIGTVPTVDLASRYECAAVILHSPLMSGLRVAFPDTRKTYCFDAFPSIDKISKVTSPVLVIHGTEDEVIDFSHGLAMYERCPRAVEPLWVEGAGHNDIELYAQYLERLKQFISHELPNS
Protein: F10A16.6 protein (Q9M9L9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSMKRSREESQGGGNHNRFVDEGPRLNLPLTKTPELINKIESYLKVHYTCPHQQTENSSKTSTLPKSPEKLKAMNFPISTIKIGDCVFVAKNPDDIVAKFYFAKKKLLWEFLFGEPVANMPRLKSKIEIQWNDVSSFEESINSRDETGILKIELKKRPTFFTETNPQAGKHTQWKQLDYDFTGDQASYYRRHTLHFPPGVLQKNLEKLLTDSFWSKLYKVPFPVHESLYFDIGFENNNSSNGHSKTVGFNVNNGLQHDFSQVRDLKERKKIITLIGIGGVGEGEGNFSMANGGWQRNSYSHVNSLNYNTDNGLLGMQAIPPSSQVANEHYNNTQNDYTGSQFGYRMNQDEIQKMQRIGKILESQAYAVPDTQTKLTSSGMNNGPMYPPAGSYLESRLLEEWYEHTRRFQQ
Protein: 26S proteasome regulatory subunit RPN5 (Proteasome non-ATPase subunit 5) (Q12250)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase RPN11
- COP9 signalosome complex subunit 5
- 26S proteasome regulatory subunit RPN10
- Proteasome subunit alpha type-3
- 26S proteasome regulatory subunit RPN1
- 26S proteasome regulatory subunit RPN6
- 26S proteasome regulatory subunit RPN12
- Proteasome subunit beta type-6
- Ubiquitin carboxyl-terminal hydrolase 6
- Proteasome subunit beta type-4
Sequence:
MSRDAPIKADKDYSQILKEEFPKIDSLAQNDCNSALDQLLVLEKKTRQASDLASSKEVLAKIVDLLASRNKWDDLNEQLTLLSKKHGQLKLSIQYMIQKVMEYLKSSKSLDLNTRISVIETIRVVTENKIFVEVERARVTKDLVEIKKEEGKIDEAADILCELQVETYGSMEMSEKIQFILEQMELSILKGDYSQATVLSRKILKKTFKNPKYESLKLEYYNLLVKISLHKREYLEVAQYLQEIYQTDAIKSDEAKWKPVLSHIVYFLVLSPYGNLQNDLIHKIQNDNNLKKLESQESLVKLFTTNELMRWPIVQKTYEPVLNEDDLAFGGEANKHHWEDLQKRVIEHNLRVISEYYSRITLLRLNELLDLTESQTETYISDLVNQGIIYAKVNRPAKIVNFEKPKNSSQLLNEWSHNVDELLEHIETIGHLITKEEIMHGLQAK
Protein: Purine nucleoside phosphorylase (EC 2.4.2.1) (PvPNP) (A5K9M4)
Organism: Plasmodium vivax (strain Salvador I)
Function: As part of the purine salvage pathway, catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on inosine and guanosine, and to a lesser extent on 2'-deoxyinosine and 2'-deoxyguanosine.
Interaction partners:
Sequence:
MEGEMQRHIKLTKAQTTPVVLVVGDPGRVDKVKVLCDSYVDLAYNREYKSVECTYKGQKFLCVSHGVGSAGCAICFEELMNNGAKVIIRAGSCGSLQPTQMKRGDICICNAAVREDRVSHLMIYSDFPAVADYEVYATLNQVAEELKVPVFNGISLSSDMYYPHKIIPTRLEDYSKANVAVVEMEVATLMVMGTLRKVKTGGIFIVDGCPLKWDEGDFDNNLVPERLENMIKISLETCARLAKKY
Protein: (S)-ureidoglycine aminohydrolase (AtUGLYAH) (EC 3.5.3.26) (Q8GXV5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the catabolism of purine nucleotides. Can use (S)-2-ureidoglycine as substrate, but not allantoate. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:20038185}.
Interaction partners:
- Ureidoglycolate hydrolase
- Allantoate deiminase
- Allantoinase
- Uricase
- Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial
- Dihydropyrimidinase
- Dihydropyrimidine dehydrogenase
Sequence:
MRSLYLIVFIVISLVKASKSDDGFCSAPSIVESDEKTNPIYWKATNPTLSPSHLQDLPGFTRSVYKRDHALITPESHVYSPLPDWTNTLGAYLITPATGSHFVMYLAKMKEMSSSGLPPQDIERLIFVVEGAVTLTNTSSSSKKLTVDSYAYLPPNFHHSLDCVESATLVVFERRYEYLGSHTTELIVGSTDKQPLLETPGEVFELRKLLPMSVAYDFNIHTMDFQPGEFLNVKEVHYNQHGLLLLEGQGIYRLGDNWYPVQAGDVIWMAPFVPQWYAALGKTRSRYLLYKDVNRNPL
Protein: Protein STE12 (P13574)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds to the DNA sequence mediating pheromone induction (called the pheromone response element = PRE) which is found in the upstream control region of several a-, alpha- and haploid-specific genes. Involved in mating of haploids and in pseudohyphae formation in diploids.
Subcellular location: Nucleus.
Interaction partners:
- Down-regulator of invasive growth 2
- Mitogen-activated protein kinase KSS1
- Mitogen-activated protein kinase FUS3
- Ty transcription activator TEC1
- Pheromone receptor transcription factor
- Down-regulator of invasive growth 1
- Silenced mating-type protein ALPHA1
- Serine/threonine-protein kinase STE11
- Transcription activator MSS11
- Serine/threonine-protein kinase STE7
Sequence:
MKVQITNSRTEEILKVQANNENDEVSKATPGEVEESLRLIGDLKFFLATAPVNWQENQIIRRYYLNSGQGFVSCVFWNNLYYITGTDIVKCCLYRMQKFGREVVQKKKFEEGIFSDLRNLKCGIDATLEQPKSEFLSFLFRNMCLKTQKKQKVFFWFSVAHDKLFADALERDLKRESLNQPSTTKPVNEPALSFSYDSSSDKPLYDQLLQHLDSRRPSSTTKSDNSPPKLESENFKDNELVTVTNQPLLGVGLMDDDAPESPSQINDFIPQKLIIEPNTLELNGLTEETPHDLPKNTAKGRDEEDFPLDYFPVSVEYPTEENAFDPFPPQAFTPAAPSMPISYDNVNERDSMPVNSLLNRYPYQLSVAPTFPVPPSSSRQHFMTNRDFYSSNNNKEKLVSPSDPTSYMKYDEPVMDFDESRPNENCTNAKSHNSGQQTKQHQLYSNNFQQSYPNGMVPGYYPKMPYNPMGGDPLLDQAFYGADDFFFPPEGCDNNMLYPQTATSWNVLPPQAMQPAPTYVGRPYTPNYRSTPGSAMFPYMQSSNSMQWNTAVSPYSSRAPSTTAKNYPPSTFYSQNINQYPRRRTVGMKSSQGNVPTGNKQSVGKSAKISKPLHIKTSAYQKQYKINLETKARPSAGDEDSAHPDKNKEISMPTPDSNTLVVQSEEGGAHSLEVDTNRRSDKNLPDAT
Protein: ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase alpha) (Endoplasmic reticulum oxidoreductin-1-like protein) (Oxidoreductin-1-L-alpha) (Q8R180)
Organism: Mus musculus (Mouse)
Function: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins (By similarity). Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96HE7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96HE7}; Lumenal side {ECO:0000250|UniProtKB:Q96HE7}. Golgi apparatus lumen {ECO:0000250|UniProtKB:Q96HE7}. Secreted {ECO:0000250|UniProtKB:Q96HE7}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8R4A1}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum (By similarity). In neurons, it localizes to dendrites (By similarity). {ECO:0000250|UniProtKB:Q8R4A1, ECO:0000250|UniProtKB:Q96HE7}.
Interaction partners:
- Protein disulfide-isomerase A4
- Protein disulfide-isomerase
- Protein disulfide-isomerase A6
- Endoplasmic reticulum resident protein 29
- Thioredoxin domain-containing protein 5
- Endoplasmic reticulum resident protein 44
- ERO1-like protein beta
- Endoplasmic reticulum chaperone BiP
- Protein disulfide-isomerase A3
- Probable glutathione peroxidase 8
Sequence:
MGRAWGLLVGLLGVVWLLRLGHGEERRPETAAQRCFCQVSGYLDDCTCDVETIDKFNNYRLFPRLQKLLESDYFRYYKVNLKKPCPFWNDINQCGRRDCAVKPCHSDEVPDGIKSASYKYSEEANRIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDSFCEIDDIQSPDAEYVDLLLNPERYTGYKGPDAWRIWSVIYEENCFKPQTIQRPLASGRGKSKENTFYNWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQDTWLEKKWGHNVTEFQQRFDGILTEGEGPRRLRNLYFLYLIELRALSKVLPFFERPDFQLFTGNKVQDAENKALLLEILHEIKSFPLHFDENSFFAGDKNEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKLIANMPESGPSYEFQLTRQEIVSLFNAFGRISTSVRELENFRHLLQNVH
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (F7AAP4)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}.
Interaction partners:
Sequence:
MTNPPGQSVSANTVAESHEGEFGCTLMDLRKLMELRGADAVAQISAHYGGVQEICTRLKTSPIEGLSGNPADLEKRRLVFGKNVIPPKRPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPPGGDNEICGHIASSPEEEEEGETGWIEGAAILASVIIVVLVTAFNDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQIKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKTLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGASEEEDDDDKKKKGKKQGAPENRNKAKTQDGVALEIQPLNSQEGLDSEDKEKKIARIPKKEKSVLQGKLTRLAVQIGKAGLIMSVLTVVILILYFVVDNFVIQRREWLPECTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQIPQPDVFPPKVLELIVNGISINCAYTSKIQPPEKEGGLPRQVGNKTECGLLGFVTDLKQDYQAVRNEVPEEKLFKVYTFNSVRKSMSTVIRKPEGGFRMFSKGASEIMLRRCDRILNKEGEIKSFRSKDRDNMVRNVIEPMASEGLRTICLAYRDFDGTEPSWDIEGEILTSLICIAVVGIEDPVRPEVPDAIAKCKRAGITVRMVTGDNVNTARAIATKCGILTPKDDFLCLEGKEFNSLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTAGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLRRRPYGRNKPLISRTMMKNILGHAVYQLLIVFLLVFAGDTLFDIDSGRKAPLNSPPSQHYTIVFNTFVLMQLFNEINARKIHGEKNVFAGVYRNIIFCTVVLGTFFCQIMIVELGGKPFSCTSLTMEQWMWCLFIGIGELLWGQVISAIPTKSLKFLKEAGHGSDKEDISRDTEGMDEIDLAEMELRRGQILWVRGLNRIQTQIDVINKFQTEAPLKRVRENMTQHLDVKLVPSSYSAAVASLRTCPSISSAISSAVTSPPVGSE
Protein: S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent), chloroplastic (EC 2.5.1.144) (AtCS26) (Beta-substituted Ala synthase 5;1) (ARAth-Bsas5;1) (O-acetylserine sulfhydrylase) (O22682)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: S-sulfocysteine synthase that plays an important role in chloroplast function and is essential for light-dependent redox regulation and photosynthetic performance within the chloroplast. Probably unable to interact with SAT and to form the decameric Cys synthase complex (CSC) required for O-acetylserine (thiol)-lyase (OAS-TL) enzymatic activity. Lacks OAS-TL activity.
Subcellular location: Plastid, chloroplast thylakoid lumen {ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:22829322}.
Interaction partners:
- Serine acetyltransferase 1, chloroplastic
- Serine acetyltransferase 5
- Serine acetyltransferase 2
- Serine acetyltransferase 4
- Serine acetyltransferase 3, mitochondrial
- Probable cystathionine gamma-synthase 2
- Cystathionine gamma-synthase 1, chloroplastic
- 5'-adenylylsulfate reductase 2, chloroplastic
- Assimilatory sulfite reductase
- Methionine gamma-lyase
Sequence:
MAFASPSLRLLPQSPLGRITSKLHRFSTAKLSLFSFHHDSSSSLAVRTPVSSFVVGAISGKSSTGTKSKSKTKRKPPPPPPVTTVAEEQHIAESETVNIAEDVTQLIGSTPMVYLNRVTDGCLADIAAKLESMEPCRSVKDRIGLSMINEAENSGAITPRKTVLVEPTTGNTGLGIAFVAAAKGYKLIVTMPASINIERRMLLRALGAEIVLTNPEKGLKGAVDKAKEIVLKTKNAYMFQQFDNTANTKIHFETTGPEIWEDTMGNVDIFVAGIGTGGTVTGTGGFLKMMNKDIKVVGVEPSERSVISGDNPGYLPGILDVKLLDEVFKVSNGEAIEMARRLALEEGLLVGISSGAAAVAAVSLAKRAENAGKLITVLFPSHGERYITTALFSSINREVQEMRY
Protein: Ring finger protein 111 (D4A9T1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
Interaction partners:
- Mothers against decapentaplegic homolog 7
- Mothers against decapentaplegic homolog 3
- Ubiquitin-ribosomal protein eL40 fusion protein
- SKI-like proto-oncogene
- Small ubiquitin-related modifier 1
- Ski oncogene
- Polyubiquitin-C
- Mothers against decapentaplegic homolog 2
- Axin-2
Sequence:
MAAENFSWLGSIDVLSSLNAWLVSPRPSLKFPMTQWTPEYNELYTLKVAMKSGTPPDAPTTQESLKAVLLHPQPLGATKSFPAEVEMINSKVGNEFSHLCDDSQKQEKDMNDNQQEQEKSGVVRKKRKSQQAGPSYVQNCVKENQEILGLRQHLATPSDEDDDSSFSECLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQPILSAKSRSHNARSHKWPRTEAEPVPGLLMKRPCFHGSAVRRVPCRKRPVKSSSSQRTQKQKERLLVQRKKLAQRKYALLASSSTSSENDLSSDSSSSSSTDGEEDLCASASENPSNPAAPSGSIDEDVVVIEASFTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHTGRAQEPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMDSQTTSASINNSNPSTSEQGSDTTSTVASSQPSTVSETAATLTSNSATGSSVGDDVRRTASNAVPESGPPAMPRLPSCCPQHSPCGGTSQSHHALAHPHSSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVERPQVQAPCGANSSSGSSYHDQQALPVDLSNSALRTHGSGGFHGASAFDPCCPVSSSRAAVFGHQAAAAPTQPLSIDGYGSSMVAQPQPQPPPQPSLSSCRHYMPPPYASLTRALHHQASACHHSHGSAPPQTQPPPQVDYVIPHPVHAFHSQISTHAASHPVAPPPPTHLGSTAAPIPQHLPPAHQPISHHIPAPAPSAQRLHPHEVMQRMEVQRRRLMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQAPERTAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIRYISSGLDGTSFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKRKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIEAQLPSES
Protein: Complement factor H-related protein 4 (FHR-4) (Q92496)
Organism: Homo sapiens (Human)
Function: Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.
Subcellular location: Secreted.
Interaction partners:
- Complement C3
- C-reactive protein
- Complement factor B
- Complement factor H-related protein 5
- Myosin-binding protein H
- C4b-binding protein beta chain
- Complement factor H-related protein 3
- Properdin
- Complement C4-B
Sequence:
MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNCKPGYATAEGNSSGSITCLQNGWSTQPICIKFCDMPVFENSRAKSNGMWFKLHDTLDYECYDGYESSYGNTTDSIVCGEDGWSHLPTCYNSSENCGPPPPISNGDTTSFPQKVYLPWSRVEYQCQSYYELQGSKYVTCSNGDWSEPPRCISMKPCEFPEIQHGHLYYENTRRPYFPVATGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICIKFCDMPVFENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE
Protein: Nucleolar MIF4G domain-containing protein 1 isoform 1 (Nucleolar protein with MIF4G domain 1) (Q1LY17)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Eukaryotic initiation factor 4A-III
- ATP-dependent RNA helicase
- Neuroguidin
- WD repeat domain 3.
- Something about silencing protein 10
- RNA cytidine acetyltransferase
- rRNA biogenesis protein RRP36
- Nucleolar complex protein 4 homolog
- ESF1 homolog)
- U3 small nucleolar RNA-interacting protein 2
Sequence:
MKAKRQRKGKGGKQANNDKFKKLKDSVSDFVKSKGGFDKNENDQRVNFVKRKSRKDLRKEKRKMKKAKMKSHYMGQAMAKSSEELNPNTPAVKEENTHKPVLKKTTDAPQRQQKTKKGDAKTKDAKDETKSKKVHFSEDLPKQKKKSGLNESRKLALLEANVEEDREIKKLEKRLGLNKRKNKKSLPQSFTNDGLDYILGILEPGASATGLYESDEEMDIDKAKENFDELEEDSEEQMTDDEDTGDGEEEDEAQMEEEEDVEEEDTQIDDEEVEGDEEDDTDASEENEEVEEAESEQKNPESQELNPATTGKYVPPHLREAADSKRKAELEKLKRSVKGLINRLSQPNMASISSQLEELYMNTSRKDMNDTLTDILLAACVTPALMPERLLMEHILLVSVLHYSVGLEVGAHFLETVVRQFDRIYSELDGTDKECDNLVSIIAHLYNFHVVHAVLVFDILKKLVTSFSSKDIELLLLVLKTVGFALRKDDPIALKELISEAQRKASAEGEQFQDQTRIRFMLETMMALKNNDMRKIPGYDPEPVEKLRKLQRTLIHSSAGSSDMKLRVSLDNLLEAERVGRWWIVGSSWSGAPMIDDQGNKTTTPSTKGEQYSAKMLELARKQRMNTDVRRNIFCVLMSSEDFLDAYEKLLRLGLKDQQEREIVHVLMDCCLQEKMFNRFYAVLAEKLCSHDRRFQMTFQFSLWDKFRDLANLSNRSFSNLVQLVTHLLHRKSLSLSILKAIEFGELDKPKVKFLKQILSKLLKETEPEDLVNIFGRISGIPKLGMLREGLKLFISHFLLRTVNTQEPPEQAKVLKDRAEVATKAMEARDAKIKL