wanglab/gogpt-training-data huggingface dataset:
Protein: Aldehyde dehydrogenase domain-containing protein (A0A1D8PSW6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Acetyl-coenzyme A synthetase
- Acetyl-coenzyme A synthetase 2
- Pdc12p
- methylmalonate-semialdehyde dehydrogenase
- 4-aminobutyrate aminotransferase
- Glutamate decarboxylase
- Pyruvate decarboxylase
- 4-aminobutyrate aminotransferase
- amidase
- 3-hydroxyisobutyrate dehydrogenase
Sequence:
MTIPLSVDVTLPDGKKFTQPTGLFINNEFIKSKSGKTLESINPGTSEINGEVYAAESEDIDYAVECASKAFKSWKKITGVERGKYLYKLADLVEQQRDLLGAMEAWDSGKTKSTNAVFDVDECIAVIRYAASWADKITGKVIQNDPKKFAYTIHEPWGVCAQIVPWNYPLLMSMWKIPIAVAAGNTVVLKTSEITPLSMLYFASLVKQVGFPPGVINIVSGFGATAGAALASHKKVAKIAFTGSTATGKIIQKLAAENLKAVTLECGGKSPLIIRSDADIDQAVKWGAIGIMSNQGQICTSTSRIYVHESIYDKFIEEFAAHVKSDYKQGDVFDDEAVVGPQVSKMQHDKILNYIDIGKKEGARCVLGGEKNIEGELSKGYFVKPTIFADVKPEMRIVNEEIFGPVVVVGKFSTDEEAITYANQTDYGLGAAIFTKNITAAHNMASDIEAGMVWINSSNDSDYHVPFGGVKMSGVGRELGEYGLNMYTQAKAVHVNLGTRL
Protein: Subtilisin-like protease SBT3.8 (EC 3.4.21.-) (Subtilase subfamily 3 member 8) (AtSBT3.8) (Q9SZY3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q84WS0}.
Interaction partners:
- Phytosulfokines 1
- Protein GOLVEN 1
- Tripeptidyl-peptidase 2
- Putative phytosulfokines 4
- Subtilisin-like protease SBT6.1
- Phytosulfokines 3
- Transmembrane protein
Sequence:
MKSCRTLIFVAIILNGLSTFVAHAGAESKVHIVYLGEKQHDDPEFVTESHHRMLWSLLGSKEDAHSSMVHSYRHGFSGFAAKLTKSQAKKLADLPEVVHVTPDSFYQLDTTRTWDYLGLSVANPKNLLNDTNMGEEVIIGIVDSGVWPESEVFNDNGIGPVPSHWKGGCVSGENFTSSQCNKKLIGAKYFINGFLATHESFNSTESLDFISPRDRSGHGTHVATIAGGSYVPSISYKGLAGGTVRGGAPRARIAMYKACWYLDRFDINTCSSADILKAMDEAMHDGVDVLSLSIGYRFPYFPETDVRAVIATGAFHAVLKGITVVCSGGNSGPAAQTVGNTAPWILTVAATTLDRSFPTPITLGNNKLILGQAMYTGPELGFTSLVYPENPGNSNESFSGDCELLFFNSNHTMAGKVVLCFTTSTRYITVSSAVSYVKEAGGLGVIVARNPGDNLSPCEDDFPCVAVDYELGTDILLYIRSTGLPVVKIQPSKTLVGQPVGTKVADFSSRGPNSIEPAILKPDIAAPGVSILAATTTNKTFNDRGFIFLSGTSMAAPTISGVVALLKALHRDWSPAAIRSAIVTTAWRTDPFGEQIFAEGSPRKLADPFDYGGGLVNPEKAAKPGLVYDLGLEDYVLYMCSVGYNETSISQLVGKGTVCSNPKPSVLDFNLPSITIPNLKDEVTLTRTLTNVGQLESVYKVVIEPPIGIQVTVTPETLLFNSTTKRVSFKVKVSTTHKINTGYFFGSLTWSDSLHNVTIPLSVRTQILQNYYDEN
Protein: Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (C9IZQ1)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU368074}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU368074}.
Interaction partners:
Sequence:
MRLLPRLLLLLLLVFPATVLFRGGPRGLLAVAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLVEDKEEEDVSGEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYPQDYQFYIQNFTALPLNTVVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGETIFMYMFLAGLGLLVIVGLHQLLESRKRKRPIQKVEMGTSSQNDVDMSWIPQETLNQIMQSRRDKASPRRLPRKRAQKRSVGSDERRRRETH
Protein: Aldehyde oxidoreductase molybdenum-binding subunit PaoC (EC 1.2.99.6) (P77489)
Organism: Escherichia coli (strain K12)
Function: Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxification of aldehydes to avoid cell damage.
Subcellular location: Periplasm {ECO:0000305|PubMed:19368556}.
Interaction partners:
- Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA
- Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC
- Aldehyde oxidoreductase FAD-binding subunit PaoB
- Putative xanthine dehydrogenase FAD-binding subunit XdhB
- Molybdenum cofactor insertion chaperone PaoD
- Putative xanthine dehydrogenase molybdenum-binding subunit XdhA
- Adenine deaminase
- Pyrimidine-specific ribonucleoside hydrolase RihB
- Guanine deaminase
- Xanthine-guanine phosphoribosyltransferase
Sequence:
MKFDKPAGENPIDQLKVVGRPHDRIDGPLKTTGTARYAYEWHEEAPNAAYGYIVGSAIAKGRLTALDTDAAQKAPGVLAVITASNAGALGKGDKNTARLLGGPTIEHYHQAIALVVAETFEQARAAASLVQAHYRRNKGAYSLADEKQAVNQPPEDTPDKNVGDFDGAFTSAAVKIDATYTTPDQSHMAMEPHASMAVWDGNKLTLWTSNQMIDWCRTDLAKTLKVPVENVRIISPYIGGGFGGKLFLRSDALLAALAARAVKRPVKVMLPRPSIPNNTTHRPATLQHLRIGADQSGKITAISHESWSGNLPGGTPETAVQQSELLYAGANRHTGLRLATLDLPEGNAMRAPGEAPGLMALEIAIDELAEKAGIDPVEFRILNDTQVDPADPTRCFSRRQLIECLRTGADKFGWKQRNATPGQVRDGEWLVGHGVAAGFRNNLLEKSGARVHLEQNGTVTVETDMTDIGTGSYTILAQTAAEMLGVPLEQVAVHLGDSSFPVSAGSGGQWGANTSTSGVYAACMKLREMIASAVGFDPEQSQFADGKITNGTRSATLHEATAGGRLTAEESIEFGTLSKEYQQSTFAGHFVEVGVHSATGEVRVRRMLAVCAAGRILNPKTARSQVIGAMTMGMGAALMEELAVDDRLGYFVNHDMAGYEVPVHADIPKQEVIFLDDTDPISSPMKAKGVGELGLCGVSAAIANAVYNATGIRVRDYPITLDKLLDKLPDVV
Protein: AT-hook motif nuclear-localized protein 27 (DNA-binding protein ESCAROLA) (Protein ORESARA 7) (Q9S7C9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs). Negatively regulates plant innate immunity (PTI) to pathogens through the down-regulation of the PAMP-triggered FRK1 expression. Acts redundantly with AHL18, AHL22 and AHL29 in the regulation of flowering and regulation of the hypocotyl elongation. Acts as a chromatin remodeling factor that negatively regulates the leaf senescence. Acts redundantly with AHL29/SOB3 to modulate hypocotyl growth inhibition in response to light.
Subcellular location: Nucleus {ECO:0000269|PubMed:17971039, ECO:0000269|PubMed:18088311}.
Interaction partners:
- Peroxidase 55
- Probable phospholipid-transporting ATPase 4
Sequence:
MEGGYEQGGGASRYFHNLFRPEIHHQQLQPQGGINLIDQHHHQHQQHQQQQQPSDDSRESDHSNKDHHQQGRPDSDPNTSSSAPGKRPRGRPPGSKNKAKPPIIVTRDSPNALRSHVLEVSPGADIVESVSTYARRRGRGVSVLGGNGTVSNVTLRQPVTPGNGGGVSGGGGVVTLHGRFEILSLTGTVLPPPAPPGAGGLSIFLAGGQGQVVGGSVVAPLIASAPVILMAASFSNAVFERLPIEEEEEEGGGGGGGGGGGPPQMQQAPSASPPSGVTGQGQLGGNVGGYGFSGDPHLLGWGAGTPSRPPF
Protein: Probable transporter (Q9HWG8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Uncharacterized protein PA4219
- Fe
- Probable ATP-binding component of ABC transporter
- Pyochelin biosynthetic protein PchG
- Probable ATP-binding component of ABC transporter
- Pyochelin synthetase PchE
- Salicylate biosynthesis isochorismate synthase
- Pyochelin synthetase PchF
- Isochorismate pyruvate lyase
- Regulatory protein PchR
Sequence:
MLELYRHRRLVITLALLYLSQGIPIGLAMDALPTLLRQDGAPLQALAFLPLVGLPWVVKFLWAPWVDNHWSRRLGRRRSWILPMQCMVLACLLGLATLGLGVASAGWAVGLLALASLASATQDIATDGMAAEHFSGELLAKVNAVQIAGVMIGFFGGGAGSLILAGHFGQRTAFLVMACVPLASLCCVLALGRGDPHELPPAPAAKASLLRFLRRPLAPSLLALALLSAMTAVSGFGLSKLYLSDAGWALQDIGRLGMSGGLVTVFLGCGGGAWLVRRIGLWRGFALGVVLAGCSALLWYLQAGRWLALSEGLAWTCVLIGSLATGITSVAILTAAMRFAGQGGQAGTDVTAVQSTRDLGEMLASSFLVSLTAQIGYAGGFLTGSALAVLALLLALRLQAGEGRGEWKGRAEEA
Protein: Uncharacterized protein C1805.10 (Q9UTG5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MVLVEHFCIHRCTPDGVIEMLWMYQSELMGNKQPILNKDEMAANNPELEALKNQIALFHGMYGFSVETKDILKEQPTDSKSTTSSAPKNSPFSLLESYDCLQVDTATVQKVLIKRPEGCRELHSCNVLMNNDEKNTLSLTPSIFLSVMKPCPKTSVLVTTVAALWEQFNIFHGSYLFDEIEKKSSFEIIDRWWTSVLSPLECGGYLLKSLSVLPVLHSLDDPLVKKMNDVIRKEDGTMGSLILFTKSGQPRLLSLQGLRLKPEFRNLLSYYCSHNYQHLIENESADINIAHRPLTTLFSDTDSNLAITNEVGEMTLRIFCLKKKSNKRLLAILWKLGQTSSEEVSNAFTNYIIGLAPLSQSVFDSQASTGFNFKIQKRVETELDMFWYIVANCTTGLAVVNTDFPLNDAHHLWNHLENLCNNQSFNSCQLQKITRGYWISLQQKEYNSRIYVDTVADQSQTYTPTRRFTKQGSQGDFNAIHSRKVPVTHTFTYILISKTNRWNSLHDTKAKIQRFIDQFDLTPTLYD
Protein: Protein transport protein Sec61 subunit beta (Q2NKT5)
Organism: Bos taurus (Bovine)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
Sequence:
MPGPAPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
Protein: H/ACA ribonucleoprotein complex subunit 1-like protein 2 (Q9FK53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit 2-like protein
- H/ACA ribonucleoprotein complex subunit 3-like protein
- H/ACA ribonucleoprotein complex subunit 4
- Putative rRNA 2'-O-methyltransferase fibrillarin 3
- rRNA 2'-O-methyltransferase fibrillarin 1
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- rRNA 2'-O-methyltransferase fibrillarin 2
- At4g22380
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein
- Telomerase reverse transcriptase
Sequence:
MRPPRGGGSFRGRGGRDNGGRGRGRGRGRGRFGGGNYDEGPPSEVVEVATFLHACEGDAVFKLSNVKIPHFNAPIYLQNKTQIGRVDEIFGPINESLFSIKMREGIVATSYSQGDKFFISPEKLLPLSRFLPQPKGQSGGRGEGRVPPRGRGPPRGRGNFRGRGAPRGASRGFQPRGGPRGGFRGRGRA
Protein: Calmodulin, putative (Q38EV6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- IF rod domain-containing protein
- Uncharacterized protein
- Dynein assembly factor 3, axonemal
- Protein kinase, putative
Sequence:
MSFPKEWTDTWNLFDDRRSGSVTHSDVKHIIRSLGRRYTEAEFNELLHDIPDPIPYQSFVEIMQKPYNGPTEDDLRTALRAFDGNDSGQLKLSELITLLTSLGEKMPEAEVKQLLSEVHTNEDGRVNIDDLARFLCTPLPTTQPDIAELQKQLAGIS
Protein: Uncharacterized HTH-type transcriptional regulator Rv2282c (P9WMF3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- HTH-type transcriptional regulator Cmr
- Possible transcriptional regulatory protein
- Possible transcriptional regulatory protein
- Putative mycofactocin biosynthesis transcriptional regulator MftR
- Probable transcriptional regulatory protein
- Probable hydrogen peroxide-inducible genes activator
- Transcriptional regulatory protein
- Transcriptional regulatory protein
- Probable transcriptional regulatory protein
- Probable transcriptional regulatory protein
Sequence:
MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRRLASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSLRTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSEHAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVVVPPGHKWARRSRVVSARELAQTPLVTREPNSGIRDSLTAALRDTLGEDMQQAPPVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAIWVGGRTPPAGAIRDLLSHITSRST
Protein: T. brucei spp.-specific protein (Q388H3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDRQFLCGNWCLTCITTVRVSGMCLYTHTHTHIFVFPDFSLLLFAFSSSWTLFFIFLKYGSFCLPSFVAVNISHLIPGLFSPLSVTARGSRRRRGRLAFCLVAAVFVCCPFTPT
Protein: Uncharacterized protein C05C10.5 (Q09230)
Organism: Caenorhabditis elegans
Interaction partners:
- LDL receptor repeat-containing protein egg-1
- Protein lilliputian
- Chitin-binding domain protein cbd-1
- Chondroitin proteoglycan 4 domain-containing protein
- RING-type domain-containing protein
- Pumilio domain-containing protein 5
- Uncharacterized protein
- CCCH-type zinc finger protein oma-2
- G2/mitotic-specific cyclin-B
- Protein mom-2
Sequence:
MEHFHGNRWDQLRAVEADILCPPPADPFQIFPSGWTRASELSEKGWRELLDRRRSQSPPPREPSPDVRRAIRRTPPPRVNRVAPIRLPERRPLRQLNANDARRPAQDAANRINQENMRAGNIDNGQPRRRALSPTQLPGVRAIPKDFNRFFRGLLTPGEFFAKSQTRYLGPFDEMPTEDTLPAADEYIILQRMGRLPDSGKSIFRQVGNLST
Protein: Myomesin 2 (Q80UL0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
WEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGTSENSQESEVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGSAIIGYYLDKREVHHKNWHEINSSPVKERILTVE
Protein: Symplekin C-terminal domain-containing protein (Q584L2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEAFIEAARQAVTVAAVDFGPVQQLAEDAAKGVADGEALRETITTLVDTYSAADSSQVVLQCSLMKAIGSILCATASNIGGSNCQLAVDDYILLALFFNEISTVGDVQLFSLLTEAVTALFRQTAAVAFKSALSPSSNETEDCSSITSLRGELQSLRLVMAKRLVGPSNASEFVSKQHQRHDTAMQLKVIDCLRVLLLSLLEVSNSEDATLAAVKEMQKGGTGNEAALQAARQVVEGLFLPLSTAVDALRPHVTNSSSGKGRLLVTPQPNGAHGTAVSPLVLVSTFRVVEELLWHCAGRGTDDSIVVVGRFAANRLLTAVQQYLVLQQQKSVESTGTESQEKPAAAFDVLRAAGPQRAIRRLLSVVHRQLPVFPSIESAVTAAIGVFGGQLDVDDPLKLTNLQQDGVGAENGCNNATDVSGDNRICAAKWEEAPSSSATSRLRECEQILPAPSSDAVVNEGAAADFDDPTLMEDGADGGPRETLLKSTVGPLPANALVEMVFLSISRLDIINEQGIQLLHMQGLQQQQYEAVRRAQRAELQRLRRIEQQGVENIPVGRLLEHLKESTAMYAAGAQLLSNESGLATMQRAALFSLLDAYDLLVDAQEGRVREAQALIARTIAQMPSSMMDSALDAVCARLKKELAAASSFQKTRGGSPVAKVPPLTSAYQLALQVLFMLYSAQAPVHEHDGKALMFAVSPSSAFANMGGEVQLQSRAVLTIDTENPVDWLQAPDMQSSLTDRKRPRDDGSSFGGNDLDSFHREGVSGSEEAQSATDGPSRFFREDSIQNPCVYSHFLCRMMEVLTEGEMPVLLLDLLLQCPRITRYVWHYLHKHYCLSPEKARCLLGMWLLKSVAARRAVCRRYALNSLLYMTTSRSEYPRRLAVKQLGALLASSAGLDGRRVIDDNVETLLVRHAKRQIAAIPVTRLPTAVTSSGSAVAKQEEGETTMTGGDAAETRAKELQKLTEALDRHLGPFLMLCARQPRELIPALLDVFKECVERQNTAMVQLLADHVDVRRMCQRLFQTDALSFMSNVMPYLRRYSNSATMLVQRILWAVSAELRSMGKGGEVSAADLEGIAAALLGHARVMYENSEIPFVYHSALASNGEPADVVNVQESPASLHDVRFIAPFMSLIPMEELKRTYLRSFLHFVEQQLQQRAEETMDNDTAPESMRMSEEEMSRLIRDVAQEVLVRSPVQFSDGSPRGVSRVDLLVYLHHATRGVRDGDAYQSKAHQSSPHSTVVETPMRTHAETRGILSSSGPQSPDGSVVGNNAKARTAEGETSLIAENLPLSALTTKEVICVLLKLRRTFDESTTEYLYGPAEIKGAVRQLMKNTGATKVPSQLMATLIFACGLHPPRAAVDLVRFVHQEVLLPLAKDGTWEKDVQLWRGVLLFAEMHYRECSSFLVNLPDQVLIEALRVRPQLCEYFREEHGNNAYFGHILGSL
Protein: Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) (Q9CY50)
Organism: Mus musculus (Mouse)
Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Translocon-associated protein subunit gamma
- Translocon-associated protein subunit beta
- Translocon-associated protein subunit delta
- Calnexin
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- Derlin-1
- Protein transport protein Sec61 subunit beta
Sequence:
MRLLPRLLLLFLLAFPAAVLLRGGPGGSLALAQDPTEDEEIVEDSIIEDEDDEAEVEEDEPTDLAEDKEEEDVSSEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYPQDYQFYIQNFTALPLNTVVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGETIFMYMFLAGLGLLVVVGLHQLLESRKRKRPIQKVEMGTSSQNDVDMSWIPQETLNQINKASPRRQPRKRAQKRSVGSDE
Protein: Glutathione S-transferase T2 (AtGSTT2) (EC 2.5.1.18) (GST class-theta member 2) (Glutathione S-transferase 10B) (Q8L727)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Peroxisome {ECO:0000269|PubMed:19174456}.
Interaction partners:
- Methionine--tRNA ligase, cytoplasmic
- Glutathione S-transferase DHAR2
- Subtilisin-like protease SBT4.9
- Subtilisin-like protease SBT4.4
- Putative defensin-like protein 3
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Glutathione S-transferase U25
- Glutathione S-transferase U28
- Glutathione S-transferase TCHQD
Sequence:
MKLKVYADRMSQPSRAVLIFCKVNEIQFDEILISLGKRQQLSPEFKEINPMGKVPAIVDGRLKLFESHAILIYLSSAYASVVDHWYPNDLSKRAKIHSVLDWHHTNLRPGASGYVLNSVLAPALGLPLNPKAAAEAENILTNSLSTLETFWLKGSAKFLLGGKQPSIADLSLVCELMQLQVLDDKDRLRLLSPHKKVEQWIESTRKATMPHSDEVHEVLFRAKDRFQKQREMATASKPGPQSKIIQFSSIGGTSDGPNLVQDTTDRKARRRKWSPPDDVILISAWLNTSKDRKVVVYDEQQAHTFWKRIGAHVSNSASLANLPKREWNHCRQRWRKINDYVCKFVGCYDQALNQRASGQSEDDVFQVAYQLYYNNYMSNFKLEHAWRELRHNKKWCSTYTSENSKGGGSSKRTKLNGGGVYSSSCNPESVPIALDGEEQVMDRPLGVKSSKQKEKKVATKTMLEEREADSRSRLENLWVLDEEEQVMDLPLGVKSSKQKERKVATKTMIEEREAANFRSRLGNLWLLKEKEEREADSRSRLENLWALKEKDIEEQKKLTRMEVLKSLLGRRTGETSEKEETLKNKLIDEML
Protein: Myeloid-associated differentiation marker (Protein SB135) (Q96S97)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Plasmolipin
Sequence:
MPVTVTRTTITTTTTSSSGLGSPMIVGSPRALTQPLGLLRLLQLVSTCVAFSLVASVGAWTGSMGNWSMFTWCFCFSVTLIILIVELCGLQARFPLSWRNFPITFACYAALFCLSASIIYPTTYVQFLSHGRSRDHAIAATFFSCIACVAYATEVAWTRARPGEITGYMATVPGLLKVLETFVACIIFAFISDPNLYQHQPALEWCVAVYAICFILAAIAILLNLGECTNVLPIPFPSFLSGLALLSVLLYATALVLWPLYQFDEKYGGQPRRSRDVSCSRSHAYYVCAWDRRLAVAILTAINLLAYVADLVHSAHLVFVKV
Protein: Chromosome alignment-maintaining phosphoprotein 1 (A0A2R8Y735)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEAFQELRKPSARLECDHCSFRGTDYENVQIHMGTIHPEFCDEMDAGGLGKMIFYQKSAKLFHCHKCFFTSKMYSNVYYHITSKHASPDKWNDKPKNQLNKETDPVKSPPLPEHQKIPCNSAEPKSIPALSMETQKLGSVLSPESPKPTPLTPLEPQKPGSVVSPELQTPLPSPEPSKPASVSSPEPPKSVPVC
Protein: Phosphodiesterase (EC 3.1.4.-) (A0A8I6A9G5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGDVRLRGQTGVPAERRGSYPFIDFRLLNNTTHSGEIGSKKKVRRLLSFQRHFHESRLLRGMTPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLVMVQEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLENIQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGDLEQKFELEISPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTLSESMLNHLAHNKAQWKSLLSNQHRRRGSGQDPAGTAPETLEQTEGATP
Protein: Signal recognition particle subunit SRP21 (Signal recognition particle 21 kDa protein) (P32342)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:11352936}.
Interaction partners:
- Signal recognition particle subunit SRP72
- Signal recognition particle subunit SRP14
- Signal recognition particle subunit SRP68
- Signal recognition particle subunit SRP54
- Signal recognition particle subunit SEC65
- Signal recognition particle receptor subunit alpha homolog
- Signal recognition particle receptor subunit beta
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL38
Sequence:
MSVKPIDNYITNSVRLFEVNPSQTLFSISYKPPTQKTDTKVSFRTHNSHLSLNYKFTTNKSKDVSRLLSALGPRGVSITPGKIEKIAQSKKKNNKIKESSKKIKGKSIQDIVGLATLIVNTDVEKSDPAAKKTATEPKQKANAVQNNNGNSAASKKKKNKNKGKKKR
Protein: F14J22.5 protein (PLC-like phosphodiesterases superfamily protein) (Q9FXA0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Type I inositol polyphosphate 5-phosphatase 10
- Small ribosomal subunit protein uS4m
- Protein DAY-LENGTH-DEPENDENT DELAYED-GREENING 1, chloroplastic
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- At5g19500
- Type I inositol polyphosphate 5-phosphatase 4
- Type I inositol polyphosphate 5-phosphatase 8
- Membrane lipoprotein
- ADP,ATP carrier protein
- Probably inactive leucine-rich repeat receptor-like protein kinase At3g28040
Sequence:
MFQRLLLFLLIALLLQSSFLLEISSALKEGKTCITNSNCDAGLHCETCIANTDFRPRCSRTQPINPITKAKGLPFNKYSWLTTHNSFARLGEVSRTGSAILAPTNQQDSITSQLNNGVRGFMLDMYDFQNDIWLCHSFDGTCFNFTAFQPAINILREFQVFLEKNKEEVVTIIIEDYVKSPKGLTKVFDAAGLRKFMFPVSRMPKNGGDWPRLDDMVRKNQRLLVFTSDSHKEATEGIAYQWKYMVENQYGNGGLKVGVCPNRAQSAPMSDKSKSLVLVNHFPDAADVIVACKQNSASLLESIKTCYQAAGQRWPNFIAVDFYKRSDGGGAPQAVDVANGNLICGCDNFAACKADGKCG
Protein: UDP-N-acetylglucosamine transporter (Golgi UDP-GlcNAc transporter) (Solute carrier family 35 member A3) (O77592)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Y2D2}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Solute carrier family 35 member D2.
- RAB14, member RAS oncogene family.
- Major facilitator superfamily domain containing 14A.
- Chitinase domain containing 1
- Major facilitator superfamily domain containing 14B.
- Solute carrier family 35 member B4.
- Hexosyltransferase.
- Helicase for meiosis 1.
Sequence:
MSTNLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAELLKIMACILLVYKDSKCSLRALNRILHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLSKKLGVYQWLSLVILMTGVAFVQWPSDSQELDSKELSAGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYIYDGELVSKNGFFQGYNRLTWIVVILQALGGLVIAAVIKYADNILKGFATSLSIILSTLISYFWLQDFVPTSVFFLGAILVITATFLYGYDPKPTGNPTKA
Protein: Uncharacterized protein (C8VUL7)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MRFSSLFGGLLLAGAAIAQNTSCSPKSSDAEVIEYAYALQGLLERYYTSQPINQTFLRDATNGSRVEYYQNLLGIQRQNRLGVRALQQVGSQIPGFSNPRCDYSIPNATSGEDYVKNAAVLEGSVASAFIGATGYTQSPEVSFILARLAAVHTADASWLAAEQRSVVFPSNVSSLVPAYNPEYVLGSGKEPGRLGQYLQDCVTAPSDPCGQTFFIGPLVGSVGNRSSAAAVPSGSSASITPSISPTAAARRRFGF
Protein: WD repeat-containing protein 48 (USP1-associated factor 1) (Q8BH57)
Organism: Mus musculus (Mouse)
Function: Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme. Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes.Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8TAF3}. Cytoplasm {ECO:0000250|UniProtKB:Q8TAF3}. Lysosome {ECO:0000250|UniProtKB:Q8TAF3}. Late endosome {ECO:0000250|UniProtKB:Q8TAF3}. Note=Mainly in cytoplasmic compartments. {ECO:0000250|UniProtKB:Q8TAF3}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 1
- Ubiquitin carboxyl-terminal hydrolase 12
- Ubiquitin carboxyl-terminal hydrolase 46
- Fanconi anemia group I protein homolog
- WD repeat-containing protein 20
- WD repeat-containing protein 20
- RAD51-associated protein 1
- E3 ubiquitin-protein ligase FANCL
- Fanconi anemia group D2 protein homolog
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDVVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLHRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVTPMDEEENEVNHVSGGQESRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETEAMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST