wanglab/gogpt-training-data huggingface dataset:
Protein: NF-X1-type zinc finger protein NFXL1 (AtNFXL1) (EC 2.3.2.-) (Q9SY59)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates E2-dependent ubiquitination (By similarity). Confers resistance to osmotic stress such as high salinity. Promotes H(2)O(2) production. Negative regulator of some defense-related genes via an salicylic acid (SA)-dependent signaling pathway. Confers susceptibility to the compatible phytopathogen Pseudomonas syringae pv. tomato strain DC3000 (Pst DC3000). Mediates resistance to type A trichothecenes (phytotoxins produced by phytopathogenic fungi).
Subcellular location: Nucleus {ECO:0000269|PubMed:16905136, ECO:0000269|PubMed:18069941}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase FKBP12
- Large ribosomal subunit protein uL18y
- Histone deacetylase complex subunit
- Probable WRKY transcription factor 3
- Small ribosomal subunit protein eS12z
- Small ribosomal subunit protein eS12y
Sequence:
MSFQVRRDRSDDRSHRFNHQQTWIPRNSSTSSVVVNEPLLPPNTDRNSETLDAGSASRPVYLQRQHNASGPPSYNHHQRSSNIGPPPPNQHRRYNAPDNQHQRSDNIGPPQPNQHRRYNAPDNQHQRSDNSGPPQPYRHRRNNAPENQHQRSDNIGPPPPNRQRRNNASGTLPDNRQRVASRTRPVNQGKRVAKEENVVLTDPNLPQLVQELQEKLVKSSIECMICYDKVGRSANIWSCSSCYSIFHINCIKRWARAPTSVDLLAEKNQGDNWRCPGCQSVQLTSSKEISYRCFCGKRRDPPSDPYLTPHSCGEPCGKPLEKEFAPAETTEEDLCPHVCVLQCHPGPCPPCKAFAPPRSCPCGKKMVTTRCSERRSDLVCGQRCDKLLSCGRHQCERTCHVGPCDPCQVLVNATCFCKKKVETVICGDMNVKGELKAEDGVYSCSFNCGKPLGCGNHFCSEVCHPGPCGDCDLLPSRVKTCYCGNTRLEEQIRQSCLDPIPSCSNVCRKLLPCRLHTCNEMCHAGDCPPCLVQVNQKCRCGSTSRAVECYITTSSEAEKFVCAKPCGRKKNCGRHRCSERCCPLLNGKKNDLSGDWDPHVCQIPCQKKLRCGQHSCESLCHSGHCPPCLEMIFTDLTCACGRTSIPPPLSCGTPVPSCQLPCPIPQPCGHSDTHGCHFGDCPPCSTPVEKKCVGGHVVLRNIPCGLKDIRCTKICGKTRRCGMHACARTCHPEPCDSFNESEAGMRVTCRQKCGAPRTDCRHTCAALCHPSAPCPDLRCEFSVTITCSCGRITATVPCDAGGRSANGSNVYCAAYDEASVLQKLPAPLQPVESSGNRIPLGQRKLSCDDECAKLERKRVLQDAFDITPPNLEALHFSENSAMTEIISDLYRRDPKWVLAVEERCKFLVLGKARGSTSALKVHIFCPMQKDKRDTVRLIAERWKLGVSNAGWEPKRFTVVHVTAKSKPPTRIIGARGGAISIGGPHPPFYDSLVDMDPGLVVSFLDLPREANISALVLRFGGECELVWLNDKNALAVFHDHARAATAMRRLEHGSVYHGAVVVQSGGQSPSLNNVWGKLPGSSAWDVDKGNPWRRAVIQESDDSWGAEDSPIGGSSTDAQASALRSAKSNSPIVTSVNRWSVLEPKKASTSTLEPIAQIEESSSSKTTGKQPVEGSGEEVVDDWEKVCE
Protein: DNA repair and recombination protein RAD54 (EC 3.6.4.12) (P32863)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA.
Subcellular location: Nucleus.
Interaction partners:
- DNA repair protein RAD51
- DNA repair and recombination protein RAD52
- DNA repair protein RAD55
- DNA repair protein RAD57
- Crossover junction endonuclease MUS81
- DNA repair protein RAD59
- DNA repair and recombination protein RDH54
- ATP-dependent DNA helicase SRS2
- ATP-dependent helicase SGS1
- Meiotic recombination protein DMC1
Sequence:
MARRRLPDRPPNGIGAGERPRLVPRPINVQDSVNRLTKPFRVPYKNTHIPPAAGRIATGSDNIVGGRSLRKRSATVCYSGLDINADEAEYNSQDISFSQLTKRRKDALSAQRLAKDPTRLSHIQYTLRRSFTVPIKGYVQRHSLPLTLGMKKKITPEPRPLHDPTDEFAIVLYDPSVDGEMIVHDTSMDNKEEESKKMIKSTQEKDNINKEKNSQEERPTQRIGRHPALMTNGVRNKPLRELLGDSENSAENKKKFASVPVVIDPKLAKILRPHQVEGVRFLYRCVTGLVMKDYLEAEAFNTSSEDPLKSDEKALTESQKTEQNNRGAYGCIMADEMGLGKTLQCIALMWTLLRQGPQGKRLIDKCIIVCPSSLVNNWANELIKWLGPNTLTPLAVDGKKSSMGGGNTTVSQAIHAWAQAQGRNIVKPVLIISYETLRRNVDQLKNCNVGLMLADEGHRLKNGDSLTFTALDSISCPRRVILSGTPIQNDLSEYFALLSFSNPGLLGSRAEFRKNFENPILRGRDADATDKEITKGEAQLQKLSTIVSKFIIRRTNDILAKYLPCKYEHVIFVNLKPLQNELYNKLIKSREVKKVVKGVGGSQPLRAIGILKKLCNHPNLLNFEDEFDDEDDLELPDDYNMPGSKARDVQTKYSAKFSILERFLHKIKTESDDKIVLISNYTQTLDLIEKMCRYKHYSAVRLDGTMSINKRQKLVDRFNDPEGQEFIFLLSSKAGGCGINLIGANRLILMDPDWNPAADQQALARVWRDGQKKDCFIYRFISTGTIEEKIFQRQSMKMSLSSCVVDAKEDVERLFSSDNLRQLFQKNENTICETHETYHCKRCNAQGKQLKRAPAMLYGDATTWNHLNHDALEKTNDHLLKNEHHYNDISFAFQYISH
Protein: F-box/kelch-repeat protein At1g23390 (Q9LDE3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F-box/kelch-repeat protein At1g55270
- F-box/kelch-repeat protein SKIP20
- F-box/kelch-repeat protein At2g44130
- F-box protein PP2-A13
- F-box protein At5g52880
- F-box/kelch-repeat protein At2g24250
- F-box/LRR-repeat protein At1g67190
- F-box/kelch-repeat protein At1g64840
- Putative F-box protein At1g47730
- F-box protein At4g27050
Sequence:
MEKKKNNNNGGDFGEEESSIDGDILESILSYLPLLDLDSACQVSKSWNRAVFYSLRRLKTMPWLFVYNQRNSPPYTMATMAMAYDPKSEAWIELNTASSPVEHVSVARSSHSTLLYALSPARFSFSTDAFHLTWQHVAPPRVWRIDPIVAVVGRSLIIAGGVCDFEEDRFAVELFDIESGDGAWERCESMPDFLYESASSTWLSVAVSSEKMYVTEKRSGVTCSFNPVTRSWTKLLDLCPGECSLYSRSIGFSVNRLIMAGIIGDEYNPTGIELWEVIDSDESHLKFESIGSMPETYLEKLRGINSDWPLTSIVLNAVGDMVYVHGAAENGGEIVAAEIEGGKLCKWRTLPNADATWKKSHAAERVIVACSNVGFSDLKLAFRNNLSFLSTSKY
Protein: Prefoldin subunit 5 (Genes involved in microtubule biogenesis protein 5) (Gim complex subunit 5) (GimC subunit 5) (Q04493)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Interaction partners:
- Prefoldin subunit 2
- Prefoldin subunit 1
- Prefoldin subunit 6
- Prefoldin subunit 3
- Prefoldin subunit 4
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit theta
Sequence:
MSSQKIDLTKLNPEQLNAVKQQFDQELQHFTQSLQALTMAKGKFTECIDDIKTVSQAGNEGQKLLVPASASLYIPGKIVDNKKFMVDIGTGYYVEKSAEAAIAFYQKKVDKLNKESVQIQDIIKEKTQYSLSIEAQIRQAAIRQHEAMSKQQQQQQKKESSTA
Protein: Transmembrane 4 L6 family member 1 (Membrane component chromosome 3 surface marker 1) (Tumor-associated antigen L6) (P30408)
Organism: Homo sapiens (Human)
Subcellular location: Membrane; Multi-pass membrane protein. Note=Colocalizes with SDCBP2 in the apical region of the cell (PubMed:11102519). {ECO:0000269|PubMed:11102519}.
Interaction partners:
- Epithelial discoidin domain-containing receptor 1
- Tetraspanin-1
- Tetraspanin-7
- Integrin alpha-5
Sequence:
MCYGKCARCIGHSLVGLALLCIAANILLYFPNGETKYASENHLSRFVWFFSGIVGGGLLMLLPAFVFIGLEQDDCCGCCGHENCGKRCAMLSSVLAALIGIAGSGYCVIVAALGLAEGPLCLDSLGQWNYTFASTEGQYLLDTSTWSECTEPKHIVEWNVSLFSILLALGGIEFILCLIQVINGVLGGICGFCCSHQQQYDC
Protein: RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) (Q01844)
Organism: Homo sapiens (Human)
Function: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:16965792}. Cytoplasm {ECO:0000269|PubMed:16965792}. Cell membrane {ECO:0000269|PubMed:16965792}. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.
Interaction partners:
- ATP-dependent RNA helicase A
- U1 small nuclear ribonucleoprotein C
- RNA-binding protein FUS
- Heterogeneous nuclear ribonucleoprotein A1
- Y-box-binding protein 1
- CD99 antigen
- TAR DNA-binding protein 43
- Friend leukemia integration 1 transcription factor
- Heterogeneous nuclear ribonucleoprotein M
- Nuclear receptor subfamily 4 group A member 3
Sequence:
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQDHPSSMGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGSAGERGGFNKPGGPMDEGPDLDLGPPVDPDEDSDNSAIYVQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSMRGGLPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPLMEQMGGRRGGRGGPGKMDKGEHRQERRDRPY
Protein: 5'-3' exoribonuclease (EC 3.1.13.-) (D4A914)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Decapping and exoribonuclease protein
- 5'-3' exoribonuclease 1
- Regulation of nuclear pre-mRNA domain-containing protein
- Regulation of nuclear pre-mRNA domain-containing protein
- Pre-mRNA-processing factor 40 homolog A
- Exosome RNA helicase MTR4
- Poly
- Fas binding factor 1
- CDKN2A-interacting protein
- Regulation of nuclear pre-mRNA domain-containing protein 2
Sequence:
MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFNIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCALCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFPFDVERSIDDWVFMCFFVGNDFLPHLPSLEIREGAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPYALGSRNSPGCQVASNPRQAAYEMRMQSNSSPSISPNTSFASDGSPSPLGGLKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSEFEKGTKPFKPLEQLMGVFPAASGNFLPPTWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEENRRNSLGSDVLFVGKVHPLHDFILELYQTGSTEPVDVPPELCHGIQGKFSLDEEAILPDQTVCSPVPMLRDLTQNTAISINFKDPQFAEDYVFKAIMLPGARKPAAVLKPGDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVIPRGSGTGVYSNTAPPPANYQGNVYRPLLRGQAQIPKLMSNMRPQDNWRGPPPLFQQQRFDRSVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDHRGGRQGYPREGRKYPLPPPSGRYSWN
Protein: T cell receptor alpha variable 8-4 (T cell receptor alpha chain V region PY14) (P01737)
Organism: Homo sapiens (Human)
Function: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Subcellular location: Cell membrane {ECO:0000303|PubMed:20452950}.
Interaction partners:
Sequence:
MLLLLVPVLEVIFTLGGTRAQSVTQLGSHVSVSEGALVLLRCNYSSSVPPYLFWYVQYPNQGLQLLLKYTSAATLVKGINGFEAEFKKSETSFHLTKPSAHMSDAAEYFCAVS
Protein: Zinc finger protein KNUCKLES (Q9FFX4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as a transcriptional repressor of cellular proliferation that regulates floral determinacy and relative size of basal pattern elements along the proximo-distal axis of the developing gynoecium.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein WUSCHEL
- Floral homeotic protein AGAMOUS
- Mini zinc finger protein 2
- Protein CLAVATA 3
- Developmental protein SEPALLATA 3
- Protein SPOROCYTELESS
- Floral homeotic protein APETALA 3
- Receptor protein kinase CLAVATA1
- Protein ULTRAPETALA 1
- Chromo domain-containing protein LHP1
Sequence:
MAEPPPSYLHFVGPAKTRSSSKRHSFSSSAHPASHRLFPCQYCPRKFYTSQALGGHQNAHKRERAAARRNLGVLANSPPILDDNNTFLRPYPCFYQNPFQGSTSGNEPLQEQPTMMTMDGYDPFHPYPYVYPFALSGNNNDGGNGVMEEDEPLDLDLSLRL
Protein: Vacuolar proton pump subunit B (V-ATPase subunit B) (Vacuolar proton pump subunit B) (A0A8I6AHZ0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MATQVDGRPSGFTSNSCDPGTAREHVQVVTRNYITHPRVTYRTVCSVNGPLVVLDQVKVFEGTSGIDSQKTTCEFTGDILRTPVSEDMLGRIFNGSGKPIDKGPAVMAEDFLDINGQPINPHDRIYPEEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKAVLDYHEDNFAIVFAAMGVNMETARFFKSDFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRGGSITQIPILTMPNDDITHPIPDLTGFITEGQIYVDRQLHNRQVYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYACYAIGKDVQAMKAVVGEEALTSEDLLYLEFLQKFEKNFINQGPYENRTVFESLDLGWKLLRIFPKEMLKRIPQSVTDEFYSRQGAQQDPASDTAL
Protein: AT3g52570/F22O6_50 (Alpha/beta-Hydrolases superfamily protein) (Q8VXV0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g53545
- At5g05950
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
- Eukaryotic LigT
- Uncharacterized protein
- Transmembrane protein
- Transmembrane protein
- Calcineurin-like metallo-phosphoesterase superfamily protein
- Nuclear envelope-associated protein 2
- Phosphoglycolate phosphatase
Sequence:
MARTRIITNRFESRFLIRFLESPTLFASCFTSSRSLQTLAYEEVRTSGDRESESTALILHGLLGSGRNWRSFSRSLASSLSVSSASDWKMILVDLRNHGRSAEVEGLNPPHDLVNSAKDLADLVKASGWNWPDVVIGHSLGGKVALQFMESCARGDFGESASPPKQLWVLDSVPGEVKAEKSDGEVEKVLKTLQSLPSSIPSRKWLVDRMVELGFSRSLSEWIGSNLKRSGDSETWTFNLDGAVQMFNSYRETSYWSLLENPPKETEINFVIAEKSDRWDNDTTKRLETIANQRQNVAEGKVATHLLRNSGHWVHTDNPKGLLEIVSPNFFSPHE
Protein: Acetylcholine receptor subunit beta-like 2 (Nicotinic acetylcholine receptor beta 2) (P25162)
Organism: Drosophila melanogaster (Fruit fly)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MWHWSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPIDRQLSEIPLRKNNFMLPPDIVRQVLT
Protein: TNF-receptor-associated factor-like, isoform B (TNF-receptor-associated factor-like, isoform D) (TNF-receptor-associated factor-like, isoform E) (TNF-receptor-associated factor-like, isoform F) (TNF-receptor-associated factor-like, isoform G) (Q9VXG5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRSHLKECPRNQHNLSNQQRMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNEEIRQRLHLITDVGNIRKQNQVVEDWTRETEKAMDDLRRQMEEETNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKLEELIFENERLNREKFFQIEEFLQQINEDIKTKLGNSDYVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAMQQRIASVQNIRGHLIWRIKDYSKKLEESKQYDTILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLNVLSGEYDPLLAWPCRLQAEIIIRDQCTNVADAEDYVKTIFVRKKSDDFIQSNQYFHIPHKVITSRNYLRNDSMFIEVRVLK
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (Q9W4F5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- RH22148p
Sequence:
MDCATRKQQQLRAHHQQQQIQIQTHGRKRQQLQKQRHNHHHYYQNSQQQQKHFVWLVVGILTIFLAQHANAADLVINVPNASSNANAFYRIDYSPPFGFPEPNTTIPASDIGKDIKFSRALPGTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMGTLPIRASLAMAEKLDADLMTNKDEDEDQEQQQQQQLQLATEVKPKGSNDDEEDEEDDDDDDDDQQPLNNETTATLSSASCSSSTHDVHVVLQEAIEKPKQEQERICAGTQSHADTESDNTDSDDDDEDGDGKVAKDGAVADEDGWWY
Protein: Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) (Q96BD0)
Organism: Homo sapiens (Human)
Function: Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, taurocholate, estrone 3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2). Shows a pH-sensitive substrate specificity T4 and estrone 3-sulfate which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrierr (Probable).
Subcellular location: Cell membrane {ECO:0000305|PubMed:30343886}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Monocarboxylate transporter 8
- Hepatic sodium/bile acid cotransporter
Sequence:
MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLCQLWAEKHGARGTHEVRYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELTTESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVFSLHCPSVPMAGVTASYGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQKVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALTATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYILIMGLLYKVLGVLFFAIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQSSV
Protein: Small ribosomal subunit protein RACK1 (E9KL35)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR
Protein: Tip41p (A0A1D8PNZ9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Type 2A phosphatase-associated protein 42
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase 2A activator 1
- Serine/threonine-protein phosphatase 4 regulatory subunit 3
- Serine/threonine-protein phosphatase SIT4
Sequence:
MSETNNPASSNDKKPVVFAVPSSSTRRGINAVHVNSAREMVRLHTQGRNPPAARQANVPSIPSRVVEASHAPTKKATDSMPSKFPNIQIPLHHDETECKNPQCQHCGQIIIPSPQSSYPIQDKPSISVNGWSVFTTKKPILNSLELDHLAETKFEFPLPEMIFGNNNVRIRNDVTGGTIEFNAIDALSSLDPNCPLKVSCHEEWLKSRRSKHASLKQEQSLKKDLSEFTENLDGLKPYDWTYSTNYKGTLQNLDLKSSTLHEIPIDKLTKPDPILFFDEAILFEDELADNGISILSYKIRVMPTCLLLLCRFFLRIDDVIFRVRDTRCYIDFETNTLTREYKVQEQEYDKVMSLVKVKNNKDPKKLFRDSNWVSQNIPVLNKEIETIVVNTET
Protein: Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)] (O94985)
Organism: Homo sapiens (Human)
Function: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9EPL2}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17332754}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:17332754, ECO:0000269|PubMed:21385839}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000269|PubMed:17332754}. Note=Localized in the postsynaptic membrane of both excitatory and inhibitory synapses. {ECO:0000250|UniProtKB:Q9EPL2}.; SUBCELLULAR LOCATION: [Soluble Alc-alpha]: Nucleus {ECO:0000269|PubMed:17332754}. Note=The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000269|PubMed:17332754}.
Interaction partners:
- Kinesin light chain 1
- Kinesin light chain 2
- Kinesin light chain 4
- Amyloid-beta A4 precursor protein-binding family A member 2
- Amyloid-beta precursor protein
- Kinesin light chain 3
- Cadherin-17
Sequence:
MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDDSTLSY