wanglab/gogpt-training-data huggingface dataset:
Protein: T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM) (Q9UL17)
Organism: Homo sapiens (Human)
Function: Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs. Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Induces permissive chromatin accessibilty and CpG methylation in IFNG. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells. Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity). Required for the correct development of natural killer (NK) and mucosal-associated invariant T (MAIT) cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:33296702}.
Interaction partners:
- Trans-acting T-cell-specific transcription factor GATA-3
- Runt-related transcription factor 3
- Runt-related transcription factor 1
- Interferon gamma
- T-cell surface glycoprotein CD4
- T-cell surface glycoprotein CD8 alpha chain
- Interleukin-17A
- Forkhead box protein P3
- Lysine-specific demethylase 6B
- Granzyme B
Sequence:
MGIVEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPGGALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPGPREDYALPAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAEFRAVSMKPAFLPSAPGPTMSYYRGQEVLAPGAGWPVAPQYPPKMGPASWFRPMRTLPMEPGPGGSEGRGPEDQGPPLVWTEIAPIRPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN
Protein: Protein SUPPRESSOR OF PHYA-105 1 (EC 2.7.-.-) (Q9SYX2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Controls normal photoperiodic flowering and regulates circadian rhythms. Required for suppression of photomorphogenesis in dark-grown seedlings and for normal elongation growth of adult plants. Integral component of the COP1/SPA E3 ubiquitin-protein ligase complex. Involved in HY5, HFR1, LAF1 and CO degradation.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:10205059, ECO:0000269|PubMed:16854975}. Nucleus {ECO:0000269|PubMed:22739826}. Nucleus, PML body {ECO:0000269|PubMed:21511872}. Note=Present in nuclear bodies (NBs). {ECO:0000269|PubMed:21511872}.
Interaction partners:
- E3 ubiquitin-protein ligase COP1
- Cryptochrome-1
- Cryptochrome-2
- Transcription factor HY5
- Transcription factor HY5-like
- Phytochrome B
- Phytochrome A
- Cullin-4
- Protein SPA1-RELATED 2
- DNA damage-binding protein 1a
Sequence:
MPVMERVAEETVATNNIQLKARVDDVPCNKLDARHNDMVIQSETANSDCPGSSAHRNVDLTKPPPPEEAAGAKLSVEELTLGNYRIVQGSNNTNVDSPRAGKFEHLYRLARGSAFRAGDGDLDSQPRDMDQMLSRIRQQLAGAPSERQNLKPFMSRRSDQNLEAFSERLRAAGENSIMNAPALISEGVQMKTPVSSSNFSQLLLKRAMKGKGVVGKNQETPPEFVSDQDLGSKEKKLDISKSPTPHDVLPLKSSPKGNGMVSHGDGNHSKSSIGISLREFLRSSYAKREKRHGLCLFRQLVELVDSAHSKRLFLLDLRPSLFTLVPSKKLRYIGNFGKNDLESDVDEDLNRRRPVVEESSSGGRDSKKRKMDLHLNSPGNQLQATSTGRPFKRKSPVIDLNMVDARNPDSCELQQQDYIKNLSVSSVSRKQSMSTWLEEQWYTCPEEINGEDIGEKSNIYALGVLLFELLCHCESGEMHAAMMADLRHRILPPTFLSKYPKEAGFCLWLLHPEPSSRPSARDILKSELICEDDSVKSTAAAEEISELLLHFLSSLEVQKKKKASKLLQDIQTLEDDIKEAERRYSSNVSLVRSHGAIEKRVQSSPLDEHCTTSSALFVPTANTDRLMSNIRQLEDAYFFMRSQINLSSSAATARSDKTLKDRDRCSENQNENQDMSTKGKSSDQLEVFFEGLCKFARYSKFETCGTIRSGDLLNSASVVCSLSFDPDEEHIAAAGISKKIKIFDFNAFMNESVGVHYPLVEMVNKSKLSCVCWNSYIKNYLASTDYDGVVQIWDAGTGQGFSQYTEHQKRAWSVDFSPSDPTKFVSGSDDCSVKLWSINEKRSLGTIWSPANVCCVQFSSYSNHLLAFGSADYKVYCYDLRYVKTPWCTLAGHEKAVSYVKFMDSETIVSASTDNSLKLWNLNKTNSSGLSPGACSLTYKGHTNQKNFVGLSVLDGYIACGSETNEVYSYYKSLPMPMTSYKFGSVDPISGNEYFDDNGQFVSSVCWRKKSNMLVAANSTGNMKLLKLV
Protein: Lectin alpha chain [Cleaved into: Lectin beta chain; Lectin gamma-1 chain; Lectin gamma-2 chain] (P58908)
Organism: Macropsychanthus bicolor (Dioclea rostrata)
Function: D-mannose/D-glucose-binding lectin. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production.
Subcellular location: Vacuole, aleurone grain {ECO:0000269|PubMed:18682294}. Vacuole {ECO:0000269|PubMed:18682294}. Note=Cotyledonary membrane-bound vacuolar protein bodies.
Interaction partners:
Sequence:
ADTIVAVELDSYPNTDIGDPNYPHIGIDIKSIRSKSTARWNMQTGKVGTVHISYNSVAKRLSAVVSYTGSSSTTVSYDVDLNNVLPEWVRVGLSATTGLYKETNTILSWSFTSKLKTNSIADANSLHFTFNQFSQNPKDLILQGDATTDSDGNLELTKVSSSGDPQGNSVGRALFYAPVHIWEKSAVVASFDATFTFLIKSPDRDPADGITFFIANPDTSIPSGSGGRLLGLFPDAN
Protein: Ubiquitin-like activating enzyme (UbaB), putative (AFU_orthologue AFUA_6G10510) (Q5BAI0)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- SUMO activating enzyme
- SUMO-conjugating enzyme UBC9
- Ubiquitin-like domain-containing protein
- NEDD8-conjugating enzyme UBC12
- Autophagy-related protein 3
- Autophagy-related protein 8
- Molybdopterin synthase catalytic subunit
- HECT-type E3 ubiquitin transferase
- RNA polymerase I specific transcription initiation factor Rrn7, putative
- UV excision repair protein RAD23
Sequence:
MTRDTYLKRSLGTQANRIRESRVLLVGAGGIGCELLKNLLLTGFGEIHVIDLDTIDLSNLNRQFLFRHEHIKKPKAIVAKEVAQKFQPSARIEAYHANIKDSKFDVDWFATFNVVFNALDNLDARRHVNMMCLAADVPLIESGTTGFNGQVQVIKKNVTECYDCNSKEVPKSFPVCTIRSTPSQPIHCIVWAKSYLLPELFGTSETDTEEFDYSADADNVEEIENLQREARALKEIRQSMGSAEFAQKVFDKVFKEDINRLRGMEDMWTSRKAPEPLDFKELEGTLSTVEPEVSLKDQRVWTVSENLAVFKDSLDRLSKRLKTLQSEESGSPAVLVFDKDDVDTLDFVTASANLRATIFGIEPKSKFDTKQMAGNIIPAIATTNAMTAGLCVLQALKVLKGDYDHAKMVFLERSGARAINSESLNPPNPHCPVCSVAHARIEIDLTRATLNDLVENILRTQLKYGQEFSVNTEQGTIYDPDLEDNLPKKLSDLGITTSAFLTVIDEDEQPRVNLQLIVVAPGSPPSEEQPIVLNRIPEIPRKPQAPAPYDAEANGTSNLGKRKRDANETELNGDPPTKRVANVSISDGADKAHPIDLSEAEGGAILIDDD
Protein: Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) (P67812)
Organism: Homo sapiens (Human)
Function: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P67811}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P67811}.
Interaction partners:
Sequence:
MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVITGSESPIVVVLSGSMEPAFHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIHEKQNGHIKFLTKGDNNAVDDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYPKFKYAVLFLLGLFVLVHRE
Protein: histidine kinase (EC 2.7.13.3) (Q4WI04)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- Uncharacterized protein
- Phosphotransmitter protein Ypd1, putative
Sequence:
MTGADETLTAASAILQTLARGPDASISDPNSSHKTTNGCDTKFAKLPGEPSQAKAAFEFELEALIRRVRHLEFQVVSHQPYPRPAPELPLSSTKNSDFLWLFGLSRLSSHEGAASNSSCGMQQETSRRRQRTRRIRREAEDNEADEALDDDDSDDDVDSRTRLVREEDISYLRNHVQKQAEEISFQKDIIAQVRDELLQQEEHTRRALTKVENEDVVLLERELRKHQQANEAFQKALREIGGIITQVANGDLSMKVQIHPLEMDPEIATFKRTINTMMDQLQVFGSEVSRVAREVGTEGILGGQAQITGVHGIWKELTENVNIMAKNLTDQVREIAAVTTAVAHGDLSQKIESRAQGEILELQQTINTMVDQLRTFATEVTRVARDVGTEGVLGGQAQIEGVQGMWNELTVNVNAMANNLTTQVRDIATVTKAVAKGDLTQKVQANCKGEIAELKNIINSMVDQLRQFAQEVTKIAKEVGTDGVLGGQATVNDVEGTWKDLTENVNRMANNLTTQVREIADVTTAVAKGDLTKKVTANVQGEILDLKSTINGMVDRLNTFAFEVSKVAREVGTDGTLGGQAKVDNVEGKWKDLTDNVNTMAQNLTSQVRSISDVTQAIAKGDLSKKIEVHAQGEILTLKVTINHMVDRLAKFATELKKVARDVGVDGKMGGQANVEGIAGTWKEITEDVNTMAENLTSQVRAFGEITDAATDGDFTKLITVNASGEMDELKRKINKMVSNLRDSIQRNTAAREAAELANRTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDDLKPYTREMLNVVHNLANSLLTIIDDILDISKIEANRMVIESIPFTVRGTVFNALKTLAVKANEKFLSLTYQVDNTVPDYVIGDPFRLRQIILNLVGNAIKFTEHGEVKLTIRKSDREQCAPNEYAFEFSVSDTGIGIEEDKLDLIFDTFQQADGSTTRRFGGTGLGLSISKRLVNLMGGDVWVTSEYGHGSTFHFTCVVKLADQSLNVIASQLMPYKHHRVLFIDKGQNGLQAENIIKMLKQLELEPIVVRDEDHVPPPEIQDPSGKESGHAYDVIIVDSVDTARLLRTYDDFKYVPIVLVCPLVCVSLKSALDLGISSYMTTPCQPIDLGNGMLPALEGRSTPITTDHSRSFDILLAEDNDVNQKLAVKILEKHNHNVSVVGNGLEAVEAVKKRRYDVILMDVQMPVMGGFEATGKIREYEREAGLSRTPIIALTAHAMLGDREKCIQAQMDEYLSKPLKQNQMMQTILKCATLGGSLLEKSKESRLSSSGEIHHHSEGKRPGMETRSITASGSIDRGFSSPAAAKDDEIAMERVSDYRSPKAV
Protein: Vesicle-associated membrane protein-associated protein SCS22 (VAMP-associated protein SCS22) (VAP homolog 2) (Q6Q595)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Targets proteins containing a FFAT motif to membranes (By similarity). Involved in regulation of phospholipid metabolism.
Subcellular location: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Interaction partners:
- Oxysterol-binding protein homolog 3
- Oxysterol-binding protein homolog 2
- Tricalbin-1
- Increased sodium tolerance protein 2
- Choline-phosphate cytidylyltransferase
- Tricalbin-2
- Cholinephosphotransferase 1
- Tricalbin-3
- Oxysterol-binding protein homolog 1
- Inositol-3-phosphate synthase
Sequence:
MRIVPEKLVFKAPLNKQSTEYIKLENDGEKRVIFKVRTSAPTKYCVRPNVAIIGAHESVNVQIVFLGLPKSTADDEMDQKRDKFLIVTLPIPAAYQNVEDGELLSDWPNLEEQYKDDIVFKKIKIFHSVLPKRKPSGNHDAESARAPSAGNGQSLSSRALLIITVIALLVGWIYY
Protein: Programmed cell death 1 (D3ZIN8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Programmed cell death 1 ligand 2
- Programmed cell death 1 ligand 1
- Tyrosine-protein phosphatase non-receptor type 11
- Tyrosine-protein phosphatase non-receptor type 6
- T-lymphocyte activation antigen CD80
- T-cell surface glycoprotein CD4
- T-lymphocyte activation antigen CD86
- Cytotoxic T-lymphocyte protein 4
- Interferon gamma
- Interleukin-2
Sequence:
MWVQQVPWSFTWAVLQLSWQSGWLLEVLNKPWRPLTFSPTWLTVSEGANATFTCSFSNWSEDLKLNWYRLSPSNQTEKQAAFCNGYSQPVRDARFQIVQLPNGHDFHMNILDARRNDSGIYLCGAISLPPKAQIKESPGAELVVTERILETPTRYPRPSPKPEGQFQGLVIVIMSVLVGIPVLLLLAWALAAFCSTGMSEAREAGRKEDPPKEAHAAAPVPSVAYEELDFQGREKTPEPAPCVHTEYATIVFTEGLDASAIGRRGSADGPQGPRPPRHEDGHCSWPL
Protein: Betacellulin (Q64EU6)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Receptor protein-tyrosine kinase.
- Proepiregulin
- Epidermal growth factor receptor
- Amphiregulin
- Epigen
- Proheparin-binding EGF-like growth factor
- Protein kinase domain-containing protein.
- Uncharacterized protein.
- Pro-neuregulin-2, membrane-bound isoform
Sequence:
MEAAAVPVPGGGPGPLLLCLALASGLALFSCVGADANVTEGLPCEGCAGNVTQLRRRGHFSRCPEEYRHYCVKGRCRFLVAEAAPACMCERGYTGARCEQVDIFYLRGDRGQIVVISLIAAVVTLIVFVVCVCLCAHHCRKQRRKRKEEEMETLNKNAPSRSEDVLETDVA
Protein: Probable sucrose-phosphate synthase 3 (EC 2.4.1.14) (Sucrose phosphate synthase 3F) (AtSPS3F) (UDP-glucose-fructose-phosphate glucosyltransferase) (Q8RY24)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in photosynthetic sucrose synthesis by catalyzing the rate-limiting step of sucrose biosynthesis from UDP-glucose and fructose- 6-phosphate. Involved in the regulation of carbon partitioning in the leaves of plants. May regulate the synthesis of sucrose and therefore play a major role as a limiting factor in the export of photoassimilates out of the leaf. Plays a role for sucrose availability that is essential for plant growth and fiber elongation.
Interaction partners:
- Granule-bound starch synthase 1, chloroplastic/amyloplastic
- Probable sucrose-phosphatase 3b
- Probable sucrose-phosphatase 3a
- Probable sucrose-phosphatase 1
- UTP--glucose-1-phosphate uridylyltransferase 1
- Probable sucrose-phosphatase 2
- UTP--glucose-1-phosphate uridylyltransferase 2
- Glucose-1-phosphate adenylyltransferase small subunit, chloroplastic
- Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic
- Glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic
Sequence:
MAGNEWINGYLEAILDSQAQGIEETQQKPQASVNLREGDGQYFNPTKYFVEEVVTGVDETDLHRTWLKVVATRNSRERNSRLENMCWRIWHLTRKKKQLEWEDSQRIANRRLEREQGRRDATEDLSEDLSEGEKGDGLGEIVQPETPRRQLQRNLSNLEIWSDDKKENRLYVVLISLHGLVRGENMELGSDSDTGGQVKYVVELARALARMPGVYRVDLFTRQICSSEVDWSYAEPTEMLTTAEDCDGDETGESSGAYIIRIPFGPRDKYLNKEILWPFVQEFVDGALAHILNMSKVLGEQIGKGKPVWPYVIHGHYADAGDSAALLSGALNVPMVLTGHSLGRNKLEQLLKQGRQSKEDINSTYKIKRRIEAEELSLDAAELVITSTRQEIDEQWGLYDGFDVKLEKVLRARARRGVNCHGRFMPRMAVIPPGMDFTNVEVQEDTPEGDGDLASLVGGTEGSSPKAVPTIWSEVMRFFTNPHKPMILALSRPDPKKNITTLLKAFGECRPLRELANLTLIMGNRDDIDELSSGNASVLTTVLKLIDKYDLYGSVAYPKHHKQSDVPDIYRLAANTKGVFINPALVEPFGLTLIEAAAHGLPMVATKNGGPVDIHRALHNGLLVDPHDQEAIANALLKLVSEKNLWHECRINGWKNIHLFSWPEHCRTYLTRIAACRMRHPQWQTDADEVAAQDDEFSLNDSLKDVQDMSLRLSMDGDKPSLNGSLEPNSADPVKQIMSRMRTPEIKSKPELQGKKQSDNLGSKYPVLRRRERLVVLAVDCYDNEGAPDEKAMVPMIQNIIKAVRSDPQMAKNSGFAISTSMPLDELTRFLKSAKIQVSEFDTLICSSGSEVYYPGGEEGKLLPDPDYSSHIDYRWGMEGLKNTVWKLMNTTAVGGEARNKGSPSLIQEDQASSNSHCVAYMIKDRSKVMRVDDLRQKLRLRGLRCHPMYCRNSTRMQIVPLLASRSQALRYLFVRWRLNVANMYVVVGDRGDTDYEELISGTHKTVIVKGLVTLGSDALLRSTDLRDDIVPSESPFIGFLKVDSPVKEITDIFKQLSKATA
Protein: Anterior pharynx in excess protein 1 (P41990)
Organism: Caenorhabditis elegans
Function: Probable ligand for lin-12/Notch and glp-1/Notch receptors and involved in the mediation of Notch signaling. Involved in the lin-12/Notch pathway signaling of cell fate in vulval precursor cells (VPCs), acting redundantly with dsl-1 and lag-2. Contributes to the establishment of the dorsal-ventral axis in early embryos. Involved in the specification of the blastomere cell ABp fate, probably acting as a signal from the P2 blastomere to the glp-1/Notch receptor on ABp and ABa. Probably acts as a signal, from the secondary vulval epithelial cells and the vulval muscle type 1 (vm1) cells, to activate the lin-12/Notch pathway in type 2 vulval muscle (vm2) cells, contributing to formation of the postsynaptic muscle plasma membrane extensions, known as muscle arms. Required for oocyte growth control, acting redundantly with lag-2, perhaps signaling via the glp-1/Notch pathway. Plays a somatic role in ovulation during adulthood, perhaps via lin-12/Notch signaling. Involved in establishing left-right asymmetry during intestinal organogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8674418}; Single-pass type I membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:8674418}. Cytoplasm {ECO:0000269|PubMed:8674418}. Note=Nuclear localization of transcripts at 36-cell stage in embryos. {ECO:0000269|PubMed:8674418}.
Interaction partners:
- Delta-like protein dsl-1
- Suppressor of hairless protein homolog
- Protein lag-3
- Delta-like protein
- Protein lin-3
- Female germline-specific tumor suppressor gld-1
Sequence:
MTNFSSLLTTIFLCIISSATGSGTIELLISSPQTVLVEPTVCANFECAAPDDLSLARKVQRRVPLRFGTGQYHGEARERIDLHLKIIEPTSNEILALQHHRPAADTEWNSDAPIVIETSRGFNVTVQLRNLCSSNYHGKRCNRYCIANAKLHWECSTHGVRRCSAGWSGEDCSNPICAGGCSNRGRCVAPNQCSCADGFNGTRCEQCLPRAGCVNGDCVNETPNTCKCRDGFIGDRCDIDIKICSLEKPCANGGICSIDSSSSTGYKCHCPFEFVGSQCKTPLSKVRCSAEHVCKNGGACISMDDTNIQCKCRRGFSGKFCEIGNHGDCSAMRCSAGETCQISGDFAICVENDELLLTTNKPAETTKSVEKWREPRKTANDEQASDELQLRLIAAICVLFSVCVIGLALVSFFFYMHSFSKWKHPSSQQAGGSTILPTTTSIPMSTTSSGTGSPVYKVCIIDSEHRGNAPGSSSDSEPDHHCPPPHRHSPPPAYSSLVLYKKVPMAADDESSFRV
Protein: Uncharacterized protein YJL043W (P47053)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MFVDYSGLERYTDINASFGKLVNTYCCFQRCEAISEQLEILKSLVPKCHDIVALTDEDFASGRTAGLTQKLFAMAMTLHQITDCIDLLQKCNTIIPIEIANPASFESGAATAPLRQSYARLLDDWSHYMGPSTVKHTGCTNRPKWRFPWQQSRTIIIPMLFIGETAMSTRDLRSVLHDCEIRHASEMPLQLLWTSSPELVYATPHVDDYDIWSRYGSDYNMQIEDEDEASKGRQRKCVVQLEALLGALPTTDPLFQW
Protein: Cyclin-dependent kinases regulatory subunit 1 (CKS1-At) (O23249)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Associates with cyclin-dependent kinases (CDKs) and plays an essential role in the regulation of the cell cycle that affects plant growth rate. May inhibit both the G1/S and G2/M phases.
Interaction partners:
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase B2-2
- Cyclin-dependent kinase A-1
- Cyclin-dependent kinase B1-2
- Cyclin-A3-4
- Cyclin-A2-3
- Cyclin-D5-1
- Cyclin-A3-3
- Cyclin-D3-2
Sequence:
MGQIQYSEKYFDDTFEYRHVVLPPEVAKLLPKNRLLSENEWRAIGVQQSRGWVHYAVHRPEPHIMLFRRPLNYQQQQENQAQNMLVK
Protein: Lin-28 homolog B (A0A1B0GVD3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MRSFNQVSSAPGGASKGGGEEPGKLPEPAEEESQVLRGTGHCKWFNVRMGFGFISMINREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKNVAQPPASSQGRQEAESQPCTSTLPREVGGGHGCTSPPFPQEARAEISERSGRSPQEASSTKSSIAPEEQSKKGPSVQKRKKT
Protein: Uteroglobin (Club cell 17 kDa protein) (Club cell phospholipid-binding protein) (CCPBP) (Club cells 10 kDa secretory protein) (CC10) (PCB-binding protein) (Secretoglobin family 1A member 1) (Q06318)
Organism: Mus musculus (Mouse)
Function: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
Subcellular location: Secreted.
Interaction partners:
- Surfactant protein C
- Secretoglobin family 3A member 2
- Pulmonary surfactant-associated protein B
- Pulmonary surfactant-associated protein A
- Pulmonary surfactant-associated protein D
- Secretoglobin family 3A member 1
- Aquaporin-5
- Advanced glycosylation end product-specific receptor
- Forkhead box protein J1
- BPI fold-containing family A member 1
Sequence:
MKIAITITVVMLSICCSSASSDICPGFLQVLEALLMESESGYVASLKPFNPGSDLQNAGTQLKRLVDTLPQETRINIMKLTEKILTSPLCKQDLRF
Protein: Brain and acute leukemia cytoplasmic protein (Q8VHV1)
Organism: Mus musculus (Mouse)
Function: May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15749074}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q920K5}. Membrane raft {ECO:0000250|UniProtKB:Q920K5}. Postsynaptic density {ECO:0000250|UniProtKB:Q920K5}. Note=In neurons, localizes to postsynaptic lipid rafts (By similarity). In myocardial and skeletal muscle cells, localizes to the cytoplasm adjacent to the inner cell membrane, polarized to one end of the myocyte (PubMed:15749074). {ECO:0000250|UniProtKB:Q920K5, ECO:0000269|PubMed:15749074}.
Interaction partners:
Sequence:
MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDALPSAAATDSGPEAGGLHAGVLEDGLSSNGVLRPAAPGGIANPEKKMNCGTQCPNSQNLSSGPLTQKQNGLWATEAKRDAKRMSAREVAINVTENIRQMDRSKRVTKNCIN
Protein: Aurora kinase (EC 2.7.11.1) (Q54WX4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Part of a chromosomal passenger complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18326585}. Chromosome, centromere {ECO:0000269|PubMed:18326585}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18326585}. Cleavage furrow {ECO:0000269|PubMed:18326585}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P97477}. Note=When cells entered mitosis, found at spindle poles during prometaphase. With the onset of anaphase, localized at the central spindle and remained there during telophase and early cytokinesis. At the end of cytokinesis, localized at the cytoplasmic bridge and eventually to breaking points. Also found at the cleavage furrow, late in cytokinesis, when the furrow becomes a thin cytoplasmic bridge.
Interaction partners:
- Kinesin-related protein 12
- Inner centromere protein A
- Kinetochore protein Ndc80
- UBC core domain-containing protein
- Uncharacterized protein
- Probable serine/threonine-protein kinase PLK
- Kinesin-related protein 13
- Probable ubiquitin-conjugating enzyme E2 C
- Anaphase-promoting complex subunit cdc20
- Microtubule-associated protein RP/EB family member 1
Sequence:
MSYPNNKENSNNIGGGSFSVPSKQPQRVLQQQNTNINNHQTTSTVKSTITKPTTTGATTSTNTSTIPPTTTASSSSSSSSSSSSSSSSSSSSSSSSSQSVPKKKWCIDDFDIGKLLGMGRFGHVYLAREKKSQFIVALKVLFKNQLQTHNIEHQLRREIEIQSHLRHPNILRLFGYFYDDKRVFLIIEFAKGGECFKELQKVGSFNEQTAATYTLQIADALRYCHSKHVIHRDIKPENLLIGVGGEIKIADFGWSVHAPNTKRSTFCGTLEYLPPEVIEKKGYDQTADVWSLGILIFEFLVGRSPFTSDEEKNIFHNIQENDVYYPSSISPEAKDLISRLLVSDPHQRITLKDVINHPWIKKHAHPKSLEPTKLGLPLPSQMTY
Protein: Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) (A0A1D8PEA0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU365061}. Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
Interaction partners:
- Telomere replication protein EST3
- H/ACA ribonucleoprotein complex subunit NOP10
- Est1p
- H/ACA ribonucleoprotein complex subunit 2
- ATP-dependent DNA helicase II subunit 2
- DNA helicase
- H/ACA ribonucleoprotein complex subunit CBF5
- tRNA pseudouridine
- H/ACA ribonucleoprotein complex subunit
- Replication protein A subunit
Sequence:
MTVKVNEKKTLLQYVLDNTSNEVPLLPSLKEYMETVLVYQSIKRPLPAIRPQESFDEFMKELVTRLVMEKSNNVIAYGYKTSAMESRSIFTTFHSSGNFILTHITSHNWSTIFSLLGPKKFLELLVNNKGFVSKVNGESVQIFGDVNSHRKAVVVSKYITKFNVLYNSYSRDFSRFEMIRPSIQTILQDILSFSGLNPGRSSKRYRGFKSLLSRIIANDKKCRYDILYAKFIGTSKCNFANVVSNKTEISQVIQFVLLVLGKLLPLDAWGGVSNKKIIKDRVVDFLLLGANEKIHMDDLFRGIRLKDFKWLGRAHQISSKQDFELRTAFLKGYLWWLFEHLLKNILRSFWYITETSSIVSLELNYFPQYLWKELYESWVSKYAKNNLVKMPSKIQREQLPCGKIKLIPKRSSFRVICVPIKRSLKLLNKKLELDTLEKEKREFERYRKEVLSPVGQILRLKLSKLRDTYESYRASVHSSSDVAEKISDYRDSLLTRFGEIPKLFILKFDMKECYDRLSQPVLMKKLEELFENQDNKTSYYVRYYAQLDASHKLKKVKTTIDTQYHNLNILSSSRHLSNCKSLVDKTKTIALQKGNILEVCRSQIYDVVGSVKDARGNLHLYKRKRGVFQGFSLSSIFCDILYSAMVHDCFQFLWKSKQDFLFVRLVDDFLLVTPDSNIYDQVHNILSGKILESYGAFVNKDKTVVVNQTTTKPSIDFVGLEVNTTDLSIKRNSGSISLVTTNFRTFKTLVKYLKTFYQLNLEGFLLDCSFGVLENVLENMGSLLRLVLREFKTKFTSIVKYDTFHCYKFIKFLYDISNYTIVKYVETNSDWDGAPELLNCIKQIIVKEFSSFESYSEIVEWVQTLNI
Protein: Uncharacterized protein C1687.08 (O14067)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MFIFNVLTIRCTFHVLFAICYFCDHLLQYISNSRDSKAGLKIFLVFELAVTIFNTVMLQLANRVKNGLTLAILIVSVVMFVYHQQLIVNCKKMLAL
Protein: Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Sodium/hydrogen exchanger) (Solute carrier family 9 member 2) (Q3ZAS0)
Organism: Mus musculus (Mouse)
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:21900251}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Na
- Na
- Chloride anion exchanger
Sequence:
MGPRGTAHSVRAPLSWLLLLLLSLQVAVPAGALAETLLDAPRARGASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENFGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIQTVDVFAGIANFFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPATVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKIRKLTPGEMDEIREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESLRKDNSSNRERRASTSTSRYLSLPKNTKLPEKLQKKKKVSNADGNSSDSDPDVGTTVLNLQPRTRRFLPDQFSKKASQAYKMEWKNEVDVGSVRVPPSVSPAPRSKDGGTQTPGLLRQPLLSKDQRFGRGREDSLTEDVPPKPPPRLVRRASEPGNRKGRLGNEKP