wanglab/gogpt-training-data huggingface dataset:
Protein: Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta) (Q7ZUC5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR000551}. Cytoplasm, perinuclear region {ECO:0000256|PIRNR:PIRNR000551}. Nucleus {ECO:0000256|PIRNR:PIRNR000551}.
Interaction partners:
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase
- Caspase recruitment domain family, member 9
- Mitogen-activated protein kinase 8
- Stress-activated protein kinase JNK
- Stress-activated protein kinase JNK
- Stress-activated protein kinase JNK
- Raf-1 proto-oncogene, serine/threonine kinase b.
- Raf-1 proto-oncogene, serine/threonine kinase a.
- Protein kinase C delta type
Sequence:
MAPFLRIAFNAYDLGTFSPMAEAPFCAVKMKEALSTERGKTLVQKKPTMYPAWRSSFDAHIFEGRVIQILLMRTAEEPLADVTVGVSVLAERCKKANGHAEFWVDLQPSGKVMMSVQFFLEDSDTGSVCRHSVVANEEIPTLNRRRGAIKQAKIHFIKNHEFIATFFRQPTFCSVCRDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTMFQKERFKIDMPHRFKTNNYMSPTFCDHCGSLLWGLVKQGLKCEDCSMNVHHKCQTKVANLCGINQKLLAEALTQVSTKSSTKRPDNNTQDVGVYQDFNKSPGPDVTDGTPYGHIWEGSSPRPPSRITHQTRITAEHFIFHKVLGKGSFGKVLLAELKGTGEWFAVKALKKDVVLMDDDVECTMVEKRVLALAWDNPFLTHLYSTFQTKEHLFFVMEYLNGGDLMFHIQEKGRFDLYRATFYAAEIVCGLQFLHSKGIIYRDLKLDNVMLDGDGHIKIADFGMCKENVFGDNRATTFCGTPDYIAPEILLGQQYSFSVDWWSFGVLVYEMLIGQSPFHGDDEDELFESIRMDTPHYPRWILLDTRDMLERLFERDPSRRLGIVGNIRGHSFFKTVNWAALEGREVDPPFKPKVKAPNDCSNFDREFLSEKPRLSHCEKGLIDSMDQCAFAGFSFINPKMEHLITK
Protein: Interleukin 18 receptor accessory protein (A0A0G2K2K7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Interleukin 18 receptor 1
- Interleukin-18
- Ig-like domain-containing protein.
Sequence:
MLCLGWVFLWFVAGEKTTGFNHSACTTKKLLWTYSARGAENFVLFCDLQELQKQDFSHRSQSSSTLGPAHQPCSGSEKDLSDVQWYMQPRSGGPLEEINRNSPHMQNKGTLRILAPQMNSIWSYICRPRSRRPQDTACCVKTVLEVKPQRNISCGSSAQDEQVLLLGSTGSIHCPSLSCQSDVRSPEMTWYKDGRLLPEYKKNPIEMEDIYDFHQGLYVCDYTQSDNVSSWTVRAVVQVRTIDEDTNVKPDILDPVTDTLDVELGKAFTLPCRVQFGFQRYSKPVIKWYVKESTQEWEISEFVEKRIQSTLKNEVIEHTVFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEGVVFLYILLGMTVMLVGVLVAAALLYWHWIEVVLLCRTFKNKDETLRDKKEFDAFVSYANWSSPETEATGSLSEEHLALNLFPEVLENTYGYSLCLFERDVTPGGVYTDDIVSIIKRSRRGIFILSPRYINGPRVFELQAAVNLALVDQTLKLILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHATSRFWTQIRYHMPVKNSNRFMFNWLRLIPKGFSPEKDLATQKPLGGMPNSGNSHGAQNRTPDAGNRHGAQNLLLSGHQKRC
Protein: Homeobox protein SIX5 (DM locus-associated homeodomain protein homolog) (Sine oculis homeobox homolog 5) (P70178)
Organism: Mus musculus (Mouse)
Function: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Protein phosphatase EYA1
- Zinc finger protein 143
- Dystrophia myotonica WD repeat-containing protein
- Transcriptional repressor CTCF
- Protein phosphatase EYA2
- Myotonin-protein kinase
- Protein phosphatase EYA3
Sequence:
MATSPAEPSAGPAARGEAAAATEEQEEEARQLLQTLQAAEGEAAAAGAGDAAAAADSGSPSGPGSPRETVTEVPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCKSESDGNPTTEDESSRSPEDLERGVASMAAEAPAQSSIFLAGATSPATCPASSSILVNGSFLAASSPPAVLLNGSPVIINSLALGENSSLGPLLLTGGSAPQPQPSLQGVSEAKNSLVLDPQTGEVRLDEAQSEAPETKGVHGTTGEEIPGALPQVVPGPPPASTFPLTPGAVPAVAAPQVVPLSPSSGYPTGLSPTSPRLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPTNVHLINSSVGVTALQLPSSTAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPSLALPLKQEPAITVPEGALPVGPSPTLPEGHTLGPISTQPLPPASVVTSGTSLPFSPDSSGLLSSFSAPLPEGLMLSPAAVPVWPAGLELSTGVEGLGTQATHTVLRLPDPDPQGLLLGATTGTEVDEGLEAEAKVLTQLQSVPVEEPLEL
Protein: Histone deacetylase 11 (A0A8I6ALH9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MPHATQLYQHVPEKRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKFLFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYNRHIYPGDRFAKEAIRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKRDEVVFRVVRAHDIPILMVTSGGYQKRTARIIADSILNLHDLGLIGPEFPYVPARNSSIPLLSRAVP
Protein: Protein PHYTOCHROME-DEPENDENT LATE-FLOWERING (F4IDB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Triggers photoperiod-monitored flowering by repressing PHYB-dependent flowering negative regulation, probably through physical interactions with PHYB and CO.
Subcellular location: Nucleus {ECO:0000269|PubMed:24127609}. Nucleus, nuclear body {ECO:0000269|PubMed:24127609}. Cytoplasmic granule {ECO:0000269|PubMed:24127609}. Cytoplasm {ECO:0000269|PubMed:24127609}. Note=Circadian clock-regulated subcellular localization. During the night, mainly present in the cytoplasm. During the day, moves and accumulates progressively in the nuclei. {ECO:0000269|PubMed:24127609}.
Interaction partners:
- Transcriptional regulator of RNA polII, SAGA, subunit
- Transcriptional regulator of RNA polII, SAGA, subunit
- Katanin p80 WD40 repeat-containing subunit B1 homolog KTN80.3
- Katanin p80 WD40 repeat-containing subunit B1 homolog KTN80.4
- Phosphotransferases/inositol or phosphatidylinositol kinase
- Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 6b
- SAGA-associated factor 29 homolog B
- SAGA-associated factor 29 homolog A
Sequence:
MGVSFKISKVGRKFRPKISTELATPDSPKAIVLSGKPKATDDSNIGDVSGFSKPSLPDISPDHEVSFILSLYPNGYSIGKTSEAMQQISFRDVPKVLHPYDRAAEGLLSAIEAGRLPGDILEDIPCKFVDGVVICEVHDYRKHTSSQVSPVINKLRLKMSLENVVKDIPSMSDNSWTYGDLMEVESRILKALQPELCLDPLPRLDRLSKNPLTAKLDLSLSTLRRKRLRQMAEVTVMSQNKIQGKKVCIDRLPESSERGNLPGHLIMQQTNNNQAIQNLGTNMLAGLRSQPLQDAPNSSLALVPPQQQRYMGIGSTRNTQDQGSNSVSVSGASPGGLDAMLPYGSDSMNPGTSFHRKRESQEGQMSSMPGLNKRTRVSHMGPDGVPQQQLGQRMDGLHGSDTNWKNTLLQHQDMLGRSIQYPNTSIQRFSPHQMEGVMNQEGGPMQFPASQQGGMKYTSKEEPFETGKIDGGTRNNIPGVGSDANDLDPRIQSRMPHNAFIRSNFPQTSWNVNPGQQIEKEPKKEEQFSRRISAQSPRLSAGGPPQSPLSSKSGEFSGGSMGTHYGAVAAAQKDKAVTSIPAIGATQSVGSSANEAMQQRQHQAQMAAKRRTNSLPKTQVISTVGSPVSVNTISVPVNARSPSVGPQTLGDHAILDRFSKIERVAARYQLNCKKHKVDEYSRRPRVYAKQPLTVCLSNLSNEEVFKDEDEALSKSIFGGSMNTYKTRVIHFGQMERVMQGSVPSFIPRNRTRLVMSEKAVDGTVAWYQGDVDEGDVFQAEDFLLALPNTHIADLLATQFKSLMAREGYMIEEHIMAKPNRGDTGPISSHPNSAGGYPRGYSANDMQQYGDAVAGQASGEASKHGNTGNTPNNSTQNILANARMVPPTNSQALQMSQGLLSGVSMPMQPQQLDPQQSALLSSHSQQKNQQSMFTQQQHPQMQRPSMILPTNPLSAINSMSQSSGMQPGGQMANKYSPLQLQMLQQQQQAAVQKKIMMGLGSGVGMGMGMGMGMGMGSMGNSIAGLGALGNQLNMAGRGMGGTGISSSMSVPGIGNMGQNPMNLNPASNLNAISQQLRSGALTPQQNALFTQIRMGMANRGGVMGAPQTGISGVSGTRQMHPSSAGLSMLDQNRANLQRAAAMGNMGPPKLMPGMMNLYMNQQQQQQQLQQQPQQQQLQHQQQLQQPMSQPSQQLAQSPQQQQQLQQHEQPQQAQQQQQATASPLQSVLSPPQVGSPSAGITQQQLQQSSPQQMSQRTPMSPQQVNQRTPMSPQISSGAMHPMSTSNLEGCPASPQLSSQTMGSVGSITNSPMELQGPKNNSAGNNS
Protein: RE01051p (Silnoon) (Q5U154)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSSLQRDWHLQGSRGSVYCASEPDPTGGVQYESGGCLLHTKTAEGSGGGAGVDGSGGGVGLECGSLFSVVSAPPAPLPDIVVPTEMDGKHMESAAFRSGCCSPNASPMRRPATLSLDTQCCPRTLHASLLEHQISELEEDDNENLLTVSSITARPLIAKSHELRSSRKSGSGSGSGLNTARSRCVRRAKERERDRVTVARRSKQVVKDRDSSTTTTESGGPNVEPPDGGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFPSSTATVASWIPAILSALCLVLAPLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLTFGVLTGIGGGLSTTPGIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILILGGCMLHVCVSATLYRPISAYTDQDSGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAGHELSDKFIEHLFLEESKNHLNYYASKQPAQDKSAQESDDEVKDIIGETTFIKPMKKVRSSGLLHSVEDLSTDSTWVYRKHSGTDSNRGSRRRRNVFANDEVISKIQAHLEKPLSPPSVVSRGLSKSMEIPTPVSNLSDLKQQPVEQAELGILDSQLVESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDISLLQDPSFILMCLSVTLMSVGCPYMLYYLPAHVISIGYNKSEAGYLVAISAVLDLIGRLGLGWLCDLQLFDRKKTYTLCILGAGCAVLTIPFAKTLVLVGLSAAVYGLCLGSWYVLMPVLLADVFGTDRISSSYGLVRMFQSIGAISVPPLAGLMRDLSGDYEICFYCMGSCMVLGTTPLIVWSILEARNHRLFVQREEEECEEA
Protein: Transcription factor YY1 (YY1 transcription factor) (Q8CHJ4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone deacetylase 1
- Histone deacetylase 2
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Histone-lysine N-methyltransferase EZH2
- RING1 and YY1 binding protein
- SUZ12 polycomb repressive complex 2 subunit
- E3 ubiquitin-protein ligase RING1
- NAD-dependent protein deacetylase sirtuin-1
- Transcriptional repressor CTCF
- BMI1 proto-oncogene, polycomb ring finger.
Sequence:
MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEDDDEDDEDGGGGDHGGGGGHGHAGHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGSSSGGGRVKKGGGKKSGKKSYLGSGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ
Protein: AT5G44290 protein (Cyclin-dependent protein kinase-like protein) (Protein kinase superfamily protein) (Q9FKV9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- LONGIFOLIA protein
- Calcium-transporting ATPase 4, plasma membrane-type
- U1 small nuclear ribonucleoprotein 70 kDa
- Transcriptional corepressor LEUNIG_HOMOLOG
Sequence:
MGCIISKKKSPKRNPPWKETLEKRSSRINSSRIDDSSQTKEEQDRSNKVRLIESEKFSSSRFSEKHQEIAEIGDTDEDEDDDHHPPEELKREPSVVIPPSPETVSKEAELAAGWPAWLVSVAGEALVNWTPRRASTFEKLEKIGQGTYSSVYKARDLTNNKIVALKRVRFDLSDLESVKFMAREIIVMRRLDHPNVLKLEGLITASVSSSLYLVFEYMDHDLVGLASIPGIKFSEPQVKCYMQQLLSGLHHCHSRGVLHRDIKGSNLLIDSNGVLKIADFGLATFFDPQNCVPLTSRVVTLWYRPPELLLGACHYGVGVDLWSTGCILGELYSGKPILAGKTEVEQLHKIFKLCGSPTEDYWRKLKLPPSAAFRPALPYGRRVAEMFKDLPTNVLSLLEALLSIDPDRRGSAARALESEYFRTEPFACDPSSLPKYPPSKEIDAKIRDDAKRQRPTQEKHERQDSQTRRSHERKLIPPVKANNPSLSTAVENPYLRSCVPGNSQRQMQDMTCNNPTSGRVSHSGPMMKNRNLSRLTYVKDNAAPRIPSYRANSAGQGGGYVGSDQQMMDQQRKELRTFNRADTMDNSKRQTKIPNDPSWYDSGDNKMYMSGPLLAQPRKVDQMLEEHDRQLQDFTRQKAKHCRN
Protein: LP19005p (Q6AWJ8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MALEPYTKSAEIEPQLCQVIDNNEDVTTKATKCTKSNSGVGWRQMLIGFLLICFGISNSWQYKNVHMPSSSSLIASPPASAFVNTPATLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIVNNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKELIDTPKAPNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLISANTCANGSQEMMFIVQRTQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTESPTDSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSGKNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELAYKLEGVTALALDQQSDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERITVNGERRSA
Protein: Succinate semialdehyde dehydrogenase [NAD(P)+] Sad (SSADH) (SSDH) (EC 1.2.1.16) (P76149)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the NAD(+)-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources.
Interaction partners:
- 4-aminobutyrate aminotransferase PuuE
- 4-aminobutyrate aminotransferase GabT
- Succinate-semialdehyde dehydrogenase [NADP
- Succinate dehydrogenase flavoprotein subunit
- 3-sulfolactaldehyde reductase
- Succinate dehydrogenase iron-sulfur subunit
- Fumarate reductase flavoprotein subunit
- Fumarate reductase iron-sulfur subunit
- Fumarate reductase subunit D
- Succinate dehydrogenase hydrophobic membrane anchor subunit
Sequence:
MTITPATHAISINPATGEQLSVLPWAGADDIENALQLAAAGFRDWRETNIDYRAEKLRDIGKALRARSEEMAQMITREMGKPINQARAEVAKSANLCDWYAEHGPAMLKAEPTLVENQQAVIEYRPLGTILAIMPWNFPLWQVMRGAVPIILAGNGYLLKHAPNVMGCAQLIAQVFKDAGIPQGVYGWLNADNDGVSQMIKDSRIAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLNDADLELAVKAAVAGRYQNTGQVCAAAKRFIIEEGIASAFTERFVAAAAALKMGDPRDEENALGPMARFDLRDELHHQVEKTLAQGARLLLGGEKMAGAGNYYPPTVLANVTPEMTAFREEMFGPVAAITIAKDAEHALELANDSEFGLSATIFTTDETQARQMAARLECGGVFINGYCASDARVAFGGVKKSGFGRELSHFGLHEFCNIQTVWKDRI
Protein: Apoptosis inhibitor UL38 (F5HG98)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays a role in the inhibition of host apoptosis to facilitate efficient viral replication. Promotes stabilization and inactivation of host TP53 through interaction with host MDM2 (By similarity). Induces host mTORC1 activation by antagonizing the ability of host TSC1/2 to negatively regulate mTORC1. Thus, inhibits a growth regulatory pathway to facilitate viral replication. Prevents premature cell host cell death by blocking host ubiquitin-specific protease 24/USP24-mediated autophagic ferritin degradation in lysosomes thus maintaining lysosome integrity and cellular viability.
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:17202209}. Host nucleus {ECO:0000269|PubMed:17202209}. Note=localized in the host nucleus at early times postinfection and then increases in both nuclear and cytoplasmic compartments during the course of infection.
Interaction partners:
Sequence:
MTTTTHSTAAIMSLLDEAEWRQTQMDVGGLIQASALGKVALRYAVRKLMKRGARLRHDSGLYVCICDPSYEFLQMNLSKISWLERHCPPLDQELIMFGVIEAWEEASVRPTRQLVLFMTPKWDVFAYDSGILFFLAPSMAQFWHGAIVLEYWNALFPVEVRSHVRQHAHTMDDLVMVFHQLDYEKQVLEARRDKNTEGPRTFAKSVNSYVRAILESERRIREGKIPMTFVDRDSLRANSLAHIQATGAQPSHAPAQRVLSAPPSLPSPVSEEDPAAAATPPSSAATTPPSSVVPASVESELSSSPPLPPVVVKDVMYTAGEGDVVQMVVVV
Protein: Kinase suppressor of ras (Q8ISD7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSNNNAPASAPDTGSTNANDPISGSLSVDSNLVIIQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMRLNERIPANGLVPHTTGNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAMQNLRKCMESLESGTASSNNDPEQWHWDSWDRPTHIHRGSVGNIGLGNNSTASPRTHHRQHGVKGKNSALANSTNFKSGRQSPSATEELNSTQGSQLTLTLTPSPPNSPFTPSSGLSSSLNGTPQRSRGTPPPARKHQTLLSQSHVQVDGEQLARNRLPTDPSPDSHSSTSSDIFVDPNTNASSGGSSSNVLMVPCSPGVGHVGMGHAIKHRFTKALGFMATCTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGGYASLPHVHGAAKGSPLVKKSTLGKPLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPSLGKHQPSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSLIGSQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARSPSHPVNLSRSAESVF
Protein: Viral late gene transcription factor 2 (VLTF-2) (Trans-activator protein A1) (P07610)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Acts with RNA polymerase to initiate transcription from late gene promoters.
Interaction partners:
Sequence:
MAKRVSLPDVVISAPKAVFKPAKEEALACILPKYYKSMADVSIKTNSVIDKCWFCNQDLVFKPISIETFKGGEVGYFCSKICRDSLASMVKSHVALREEPKISLLPLVFYEDKEKVINTINLLRDKDGVYGSCYFKENSQIIDISLRSLL
Protein: 20S rRNA accumulation protein 4 (P25040)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for processing of the 20S pre-rRNA at site D to generate mature 18S rRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein BCP1
- Small ribosomal subunit protein uS5
- Synchronized import protein 1
- Assembly chaperone of RPL4
- Ribosome assembly protein RRB1
- rRNA biogenesis protein RRP36
- Pre-rRNA-processing protein TSR2
- Ankyrin repeat-containing protein YAR1
- U3 small nucleolar RNA-associated protein 25
- 18S rRNA aminocarboxypropyltransferase
Sequence:
MSKIEELPPSDTDDHSYSSKPGDVFLAFVDAPVKETDDILVEDSFIGGEPKWLHPDSEPPAELLKCGACKSADNMKLLLQAFSPLDDEQMSAIQQRLGINNMSYINPQDDRVLYVFLCTECQRKGNSVRCIRGVKKNKNVDSLSEKMASTSLEKDFQINPFDLSNNSDSKCNAFSSNPFGGANANPFGADSINSNISQSKDEGKKKESATVSAKTARKLHDLQKDKEYDGNKCFKSCLLYVEEETFKNKKPAHLQLPKNLKIDKEALDLTGDEDLEKDPIKLDPRTEKLSKFLDDDTFQKFQEVVGYNPLQVLRYDLGGKPLLYAETKVDILSTVPRPGYNPSSQRIFEMQLMPKMIFDLEEVVSVDNGMEWGTILVFTDVENYMPEFDEHGVGYVEECVKVQWESRT
Protein: Methylsterol monooxygenase 1-2 (EC 1.14.18.10) (EC 1.14.18.9) (Sterol 4-alpha-methyl-oxidase 1-2) (AtSMO1-2) (Q1EC69)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Non-heme iron oxygenase involved in sterols biosynthesis by catalyzing the removal of the first methyl group at the C-4 position (By similarity). 4,4-dimethyl-9-beta,19-cyclopropylsterols such as 24-methylenecycloartanol are the preferred substrates (By similarity). Acts as a rate-limiting enzyme in the sterol pathway via interaction with ACBP1; sterols serve as lipid modulators for gene expression of homeodomain-leucine zipper IV transcription factors. Together with SMO1-1, involved in the maintenance of sterol composition to balance auxin and cytokinin activities during embryogenesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29288621, ECO:0000269|PubMed:31341004}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ergosterol biosynthetic protein 28
- Sterol 14-demethylase
- Cycloartenol-C-24-methyltransferase
- 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1
- Delta
- 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 3
- 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2
- Putative Delta
- Putative sterol 14-demethylase-like protein
- 7-dehydrocholesterol reductase
Sequence:
MIPYATIEEASIALSRNLTWLETLWFDYSATKSDYYLYCHNILFLFLIFSLVPLPLVFIESSQSTSDLFNRYKIQPKVKNSFSSMFKCYKDVMKMFILVVGPLQLVSYPSIQMIEIRSGLPLPSCMEIVAQLVVYFLVEDYTNYWVHRFFHCKWGYEKFHHIHHEYTAPIGYAAPYAHWAEVLLLGIPTFLGPAIAPGHMITFWLWIALRQIEAIETHSGYDFPWSLTKYIPFYGGAEYHDYHHYVGGQSQSNFASVFTYCDYIYGTDKGYRFQKKLLQQMKEKSKKSNKLVNGGEKFD
Protein: Type 4 prepilin-like protein specific leader peptidase (EC 3.4.23.43) (Q4QNP7)
Organism: Haemophilus influenzae (strain 86-028NP)
Interaction partners:
Sequence:
MIYFTMFLLGGILGIALWFYLSGFITHLQQEIYATYVELFPQNSSPFQPHFASIQQKKCGHILRYFFSIGVGFIFLQIAFKDSIFTVWIGLTLIILWTISYLDWHYQLISTTPCLWLLTLGLFGADNNFSLLTLSESIKSAASFFIVFYAIYWIAKCYYRKEAFGRGDYWLAMALGSFIHLETLPHFLLLASVLGICFSLIHKKKKEFIPFAPFMNLSAIIIYLVKYYGY
Protein: Transcription factor 7 like 2 (A0A8I6A9A2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPQLNGGGGDDLGANDELISFKDEGEQEEKNSENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGSLSPTARTLHFQSGSTHYSAYKTIEHQIAIQYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVQSPLPCCTQGHACPHFYTPSDFTVSTQVFRDTKSSHSLQKVGEPWFLESNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPHLLGSPPQDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEAAHGKASALCPNGALDLPPATLQPSMVPSSSLAQPSTSSLHSHNSLAGTQPQPLSLVTKSLE
Protein: Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) (P37288)
Organism: Homo sapiens (Human)
Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Vasopressin-neurophysin 2-copeptin
- VIP peptides
- Oxytocin-neurophysin 1
- Guanine nucleotide-binding protein G
- Vasopressin V2 receptor
- Vasopressin V1b receptor
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit alpha-14
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
Protein: Olfactory receptor 5AS1 (Olfactory receptor OR11-168) (Q8N127)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MLESNYTMPTEFLFVGFTDYLPLRVTLFLVFLLVYTLTMVGNILLIILVNINSSLQIPMYYFLSNLSFLDISCSTAITPKMLANFLASRKSISPYGCALQMFFFASFADAECLILAAMAYDRYAAICNPLLYTTLMSRRVCVCFIVLAYFSGSTTSLVHVCLTFRLSFCGSNIVNHFFCDIPPLLALSCTDTQINQLLLFALCSFIQTSTFVVIFISYFCILITVLSIKSSGGRSKTFSTCASHLIAVTLFYGALLFMYLQPTTSYSLDTDKVVAVFYTVVFPMFNPIIYSFRNKDVKNALKKLLERIGYSNEWYLNRLRIVNI
Protein: Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (p21-activated kinase 3) (PAK-3) (p65-PAK) (Q62829)
Organism: Rattus norvegicus (Rat)
Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Rho guanine nucleotide exchange factor 7
- Cell division control protein 42 homolog
- Rho guanine nucleotide exchange factor 6
- Cytoplasmic protein
- NCK adaptor protein 1.
- small monomeric GTPase
- Ras-related C3 botulinum toxin substrate 1
- Serine/threonine-protein kinase PAK 1
- Dual specificity mitogen-activated protein kinase kinase 1
- LIM domain kinase 2
Sequence:
MSDSLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHQSNTKTASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVVESIASPAAPNKEATPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAIKNSSR
Protein: Tubulin folding cofactor B (A0A494C0X0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEVTGVSAPTVTVFISSSLNTFRSEKRYSRSLTIAEFKCKLELLVGSPASCMELELYGVDDKFYSKLDQEDALLGSYPVDDGCRIHVIDHSGARLGEYEDVSRVEKYTISQEAYDQRQDTVRSFLKRSKLGRYNEEERAQQEAEAAQRLAEEKAQASSIPVGSRCEVRAAGQSPRRGTVMYVVSLRHPGWSAVVLSAHCILCLPGSSNSHASASRVAGIIGLTDFKPGYWIGVRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPAVVTVGDFPEEDYGLDEI