wanglab/gogpt-training-data huggingface dataset:
Protein: Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain] (P22304)
Organism: Homo sapiens (Human)
Function: Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.
Subcellular location: Lysosome {ECO:0000269|PubMed:10838181}.
Interaction partners:
- Alpha-L-iduronidase
- Heparanase
- Inactive heparanase-2
- Formylglycine-generating enzyme
- Beta-glucuronidase
- Alpha-N-acetylglucosaminidase
Sequence:
MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP
Protein: Receptor-like tyrosine kinase (Tyrosine-protein kinase RYK isoform X1) (E7FAI5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MFLPARGSVGGAASAVSRGWPHTVQWRLVGFFLLLLLEGARCLANPSNSPGINNNNRPNVNIFMSEEEVKKLLGLDAELYYVRDDVVNHYALSFVLPVPSDTNSLHFTWHSSSKVDYRLGFHVENTSAMDQPQSNISVQGEVPRTRSVFRVDLFCSGKADGEAVLTVQLNLSTAANFTVLNFKRRKMCYRRIEQPEPPKTLPFPNTTIQRIDASSPNAPTTSTRVFYISVCVCCIVIFLVAIILAVLHLHSMKRVEMDDSVSDSGSSQGLSQPSTQTTQYLRADTPNNATPVTNAQTGSAPMLQLAGASFPHPGAPSHETKSYPSLRIEKNDLRSVTLLEAKAKVKDIAISRERVTLRDVLHEGTFGRIFHGVLLDEKDPSKEKQVFVKAVKDHASEVQVTMMLTESCKLRGLHHRNLLPISHVCIEDGEKPMVLLPYMNWGNLKLFLRQCKLAEANNPQAISQQDLVHMAIQISCGMSYLARREVIHKDLAARNCVIDNSMQVKITDNALARDLFPMDYHCLGDNENRPVRWMALESLLNNDFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV
Protein: NAD(P)H dehydrogenase subunit H (Q8HCQ3)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 6
- Os07g0640100 protein
- NADH dehydrogenase iron-sulfur protein 3
- NAD
- CHCH domain containing protein, expressed
- NADH-ubiquinone oxidoreductase chain 5
- NADH-ubiquinone oxidoreductase chain 3
- NAD
- NADH dehydrogenase iron-sulfur protein 3
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MTTRNGQIKNFTSNSGPQHPAAHGVSRSVLEMNGEVVERAEPHIGSLHRGTEKLIEYKTYLQALPYFDRSDYVSTMAQEHAHSSAVERLLNCEVPLRAQYIRVLFCEITRISNHSLASTTHAMDVGASTPFLWAFEEREKLLEFYERVPGARMHASFIRPGGVAQDLPLGLCRDIDSSTQQFASRIDELEEMSTGNRIWKQRLVDIGTVTAQQAKDWGFSGVMLRGPGVCWDSRRAAPYDVHDQSDLDVPVGTRGDRYDRYCIRIEEMRQSVRIIVQCPNQMPSGMIKADDRKLCPPSRSRMKLSMESSIHHFELYTEGFSVPAPSTYTAVEAPKGEFGVFLVSNGSNRPYRCKIRAPGFAHSQGLDSMSKHHMPADVVTIIGTQDIVFGEVDR
Protein: 5'-3' exoribonuclease 1 (EC 3.1.13.-) (A0A1D8PFP3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
Interaction partners:
- Decapping enzyme complex catalytic subunit
- mRNA-decapping enzyme subunit 1
- U6 snRNA-associated Sm-like protein LSm1
- mRNA decay factor PAT1 domain-containing protein
- U6 snRNA-associated Sm-like protein LSm3
- 5'-3' exoribonuclease 2
- H/ACA ribonucleoprotein complex subunit CBF5
- Enhancer of mRNA-decapping protein 3
- SKI complex RNA helicase subunit
- ATP-dependent RNA helicase DHH1
Sequence:
MGIPKFFRFISERWPLISQLIDENQIPEFDNLYLDMNSILHTCTHSNDNTITRLSDDQMYAAIFNYIEHLFQIIKPQKTFYMAIDGVAPRAKMNQQRARRFRTAYEAEINLKKAIENGEEIPKEDPFDSNSITPGTEFMANLTNNLKYFIHKKITEDSSWANIEIILSGHEVPGEGEHKIMEYIRSIRSQDDYNPNLRHCIYGLDADLIMLGLVTHDPHFALLREEVTFGPQRKVGPKDLHDQKFYLLHLSLLREYLSLEFQEIENQLNFEYDFDRILDDFILIMYVIGNDFLPNLPDLFINKGAFPLLIAAFKQTLLESDGYINENGKINLVRLNIYIKILSKFEFENFEKHEVDVEWFNKKLDDISISGEKKRQRIGKLLILKEQKKLVGFIKPWLMEWASQPINEILNLDQQGKLPTLHLNKDDVEKNLEFIKEFAIEAGFLIIHSQSNDTYEAKLDIDGISPTESEEEHEERITELRKTIKQYQSANLIESEEVLNETKEVYSEKFQSWKNDYYQPKLHFSIDTEEGKGDLIEMTKHYIEGLQWVLYYYYRGCPSWNWYYRYHYAPRISDISLGLEELINEKTDLKFELSHPFKPFEQLMAVLPARSKKLMPVVYRPLMTDEKSPIINFYPHEVDIDMNGKTASWEAVVLLDFVDEKKLIEALKPIESKLTPEEKQRNSYGHAIKFIHNPQIDHVFSSPLPGFFHDIEHDQCYEEEFKLPKIENLKIGFIKGAKTGKDLLAGFPTLSTIPFTSELALNEVKIFNFPSRSESMILNVEDVWSDLTVAQFAQSFVNKLVYSKWPFLRECRVVKVVSEENKFESIKTNTGLKKVVTNELSVEDKKSFRSEVSNLKVTWDKFKGVKLGEINALVYVKPVNGLIRNHKGAYVKTYSKDVEVYPLQLIVKEVTNKDQRYLTRPPLPIDQEFPIDSQVVFLGDMAYGSPAKIVGYNEDKTKLGVKIFKIQSTAEPNIGKKRLTIEKNEIKYYPSFEVAKTLRLNPLLLSKITSQFMVQDSSKGKVNIGLELKFESKRQKVLGYTRKSSNGKFWEFSPLAINLINTYKTKFPGLFKKLVNNVSGSNFPTVDEISSLEELKEIRSWLKEVKSELIPVSLESESFTKFSYQAIEQYMDNYLSMNQIPTINKDIKGVPREAILNANESYQLLSDQRFELGDRIIYVQDFGKVSILSKGTVASILTVGSKTSLGVIFDQPLLSGNNMNGKLNSNRGLIIDSSLVLNLTNKQFVYHSHASKNRKKLTDEEKIAKLKAIEAKKNQKQQQQQKEQQTKQKQVEQQKQKGANELLSLLKKKSDMNSTTTTSTTDGDCKKTEEKDYDKNNGNEDERVDPNAIKQIYGHIYSNVMNQGNVRPPPPPPTGPGHPQQFPYGMPIPPPGAPMHPGYIPVVPGNPLPPSFYQQYPPNGQQFVNSQPPPPPPPPPSQQQQPQVAESTSDEKSKNDNKHNVNGRGRGGSRGRGGYRGRGGVRGGRGGNKSSHQNQPKDKVKQES
Protein: Acyl-homoserine-lactone synthase (EC 2.3.1.184) (Autoinducer synthesis protein LuxI) (P12747)
Organism: Aliivibrio fischeri (Vibrio fischeri)
Function: Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L-homoserine lactone) also known as VAI or N-(beta-ketocaproyl)homoserine lactone or 3-oxo-N-(tetrahydro-2-oxo-3-furanyl)-hexanamide, an autoinducer molecule which binds to LuxR and thus acts in bioluminescence regulation.
Interaction partners:
Sequence:
MTIMIKKSDFLAIPSEEYKGILSLRYQVFKQRLEWDLVVENNLESDEYDNSNAEYIYACDDTENVSGCWRLLPTTGDYMLKSVFPELLGQQSAPKDPNIVELSRFAVGKNSSKINNSASEITMKLFEAIYKHAVSQGITEYVTVTSTAIERFLKRIKVPCHRIGDKEIHVLGDTKSVVLSMPINEQFKKAVLN
Protein: Letm1 RBD domain-containing protein (C9ZLK0)
Organism: Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
Sequence:
MFPDLIPSTFESENQGRNKAFTTLMGTVRARRRLAEYLSSTAFVSFTKEQQEVVRFSAMGEAVTANQIRLIAPHFGREGPFNVYQIPNGIAVALARTVGVYKAYHGLFLTKMAPYMRRKILRQYHKTREDDRMLRLEGLDDLTDEELIKANLVRGMRWTEDAETLRIQLEWWISLGRDPDVPYNTLFWVKPTRYSLKESMKRLPVEQRRQLLGIQHLPESIRGNLETLCETVDTAPSMSEGKPEDADQLVEKLAELNAKTKISDKDIAIQNIQISLGAYLTEPNVKRMFEDIRKSKTVNEYITVTDVIDFIGSETHNSSHVVSTVFDAFDQSSGVKAITESTLISIGARCREASKAHVDVSSQSSPGKQPSEVIAKN
Protein: Cell growth regulator with RING finger domain protein 1 (Cell growth regulatory gene 19 protein) (RING finger protein 197) (Q99675)
Organism: Homo sapiens (Human)
Function: Able to inhibit growth in several cell lines.
Subcellular location: Nucleus {ECO:0000269|PubMed:22361696}. Endoplasmic reticulum {ECO:0000269|PubMed:27485036}.
Interaction partners:
- Cell growth regulator with EF hand domain protein 1
Sequence:
MAAVFLVTLYEYSPLFYIAVVFTCFIVTTGLVLGWFGWDVPVILRNSEETQFSTRVFKKQMRQVKNPFGLEITNPSSASITTGITLTTDCLEDSLLTCYWGCSVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEIYCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRILYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEENSKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPKTL
Protein: Histidine-containing phosphotransfer protein (Q8LNY9)
Organism: Zea mays (Maize)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|RuleBase:RU369004}. Nucleus {ECO:0000256|RuleBase:RU369004}.
Interaction partners:
Sequence:
MSAANQLAALVSNMYATGLLDDQFQQLQMLQNASTPDFVSEVVTLFCQDGERIIGELAKLLEKPNVDFDRVDAFVHQLKGSSASIGAQKVKNTCIQFRESCQQKSKDGCLKTLETVKINFYDLRDKFQTMLQLQRQVNGCPPSK
Protein: T-Box protein 4 (T-box 4) (O93288)
Organism: Gallus gallus (Chicken)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00201}.
Interaction partners:
- PDZ and LIM domain protein 7
- Pituitary homeobox 1
- Fibroblast growth factor 10
- Homeobox protein Nkx-2.5
Sequence:
MLQEKSLSETEEGFPTAPAPGHADSSAGSPVLGVAGGSSTPLSSPQLPDPEQTIENIKVYLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLVSSHGQLSTKPDVNPLHGSHQTLQHYQYENGAHMQFAASDTQDLSLNTFTAQRDSGLFYHCLKRRESARHLDLPCKRSYLEASSSVGDDHYFRSPPPYEQQMLSPSYCSEVAPREACMYSGSGAEIAGVPAVDDLPPPPPPLSCNMWTSVAPYTSYSVQTMETVPYQPFPAHFTATTMMPRLPSIAGQGSQPPGNSHFSVYNQLAQSQVRERVPPSSFPRERVHPSVCERKPPSPHLNAANEFLYSQSFSLSRESSLQYHSGMGTVENWTDG
Protein: Defective proboscis extension response 16, isoform C (A0A0B4LGN7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Dpr-interacting protein epsilon
- Dpr-interacting protein gamma
- FI23040p1
- GEO10179p1
- Dpr-interacting protein zeta, isoform A
- proteasome endopeptidase complex
- Dpr-interacting protein theta
Sequence:
MPSPSGMSWRQRERGAGGTPGGRGAGILAGSGRSPGTASILLAFLAAVSFRGMRAPLAATATPMENASLIASPATGTSTMGSAGSPVLMLGDDQQQQEYDTTVVDSWSDRPDTATLTKGFSIPSYLPPFPEFIPADLPHMLRNASSGAAPPADIGPSGSPMPSKPNEQSRLHAYDSEQKAQQLRREKELAKERELLPRRQLSLPPLNATVQAGQHAYLPCKLNQHSGKPLSWVRLRDEHIIAVDHTTFINDARFASLLQSTTLTTLVSGGALSTTATPVAALGNSFAHAVPGGQERGNSSSLSWTLQIKYVNLEDAGWYECQLATEPKMSAKVQLFVITPRTELIGDRQRFVKAGSRVELHCIVRGTLEAPKYIFWYRGDQQVTAENEASGAQSGWYTQIDRNIFGSTEHNRNTIGSLVIPLVRKIHSGNYTCEPENSAAASMQLHVLSGEYSASAIKSTAARPHRLGHGYTSLHQWLIFLLVALNKT
Protein: Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) (O14607)
Organism: Homo sapiens (Human)
Function: Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 9Y
- ATP-dependent RNA helicase DDX3Y
- Lysine-specific demethylase 5D
- Eukaryotic translation initiation factor 1A, Y-chromosomal
- Zinc finger Y-chromosomal protein
- Thymosin beta-4, Y-chromosomal
- Small ribosomal subunit protein eS4, Y isoform 1
- Sex-determining region Y protein
- Putative serine/threonine-protein kinase PRKY
- ATP synthase F
Sequence:
MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCLTPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDSSLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGRRRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQTLREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLSSSS
Protein: Protein SHORT ROOT IN SALT MEDIUM 1 (AtRSA1) (Protein EMBRYO DEFECTIVE 1579) (F4IS91)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for salt tolerance and sodium (Na) homeostasis after salt stress. Together with BHLH148/RITF1, regulates the transcription of several genes involved in the detoxification of reactive oxygen species (ROS) generated by salt (NaCl) stress. Binds calcium.
Subcellular location: Nucleus {ECO:0000269|PubMed:24009530}.
Interaction partners:
- Transcription factor bHLH148
- VQ motif-containing protein 9
- 2-oxoglutarate
- Peroxidase 55
- Polyadenylate-binding protein RBP47C
- Nucleophosmin
- DEAD-box ATP-dependent RNA helicase 15
- Polyadenylate-binding protein RBP47C'
- Pre-mRNA-processing protein 40C
Sequence:
MHRDMYSSRGTGYGQQQYGSQSGYSQNLGSGYPGSSVSGGAEGGSQISLSSRHPSITGAPQETDIGGGYRSHLSTAASHYGTQYGSVYGSTSLSSSQPLSTNGLGSSVLDNRSGYVPTLPDSPKFASGSYLSPSSHGYGQKTDDLYSDKLSGYIPVDRRQYGEQSSSYLGRELQNEPTRRYADPSNFARQTDLYDRIDQASLLRGEQLLKMQSLHTSSVDAGVNRQTDYLTERSSTVRHSDQEAMHYGGRLESDPHGLSVRNTSSYASQHTPSLLGAVPRRNLDDYIYPESSSNPGYGVSLPPGRDYGTGKGIHSAASLDLDYPGGMLARGTGAAPRVDDLRKGDRASYLREFDLREEERRREDQRARDKEREREREREHDRERERQRERERQRARDRERERILERREKERQGERERERKRALEIKRDRTPTARATSKDTKERTPVPKSISRDARSSSLRRDAHHREASIRRSSPIKPIRRDYVCKVLSSRLVDMERDYVTLDKRYPRLFVPSEFSKVVVNWPKQKLTLSMHTAVSFEHDYIEDGGADVKSTSTKPLALKTGGKSVWNAKMVLMSGLSRTALEDLASDKFFEDRIPHICNILKFAVLKKDHSFMAIGGSWDPTDGMDPSVDQSSLIQTMLRHSKDKLHLDLSNCRHWNPFLEIHYDRVGTDGVFSYKEITVLFVPDLSECLPSFDVWRTQWLAHRKALTERDRLLSQEVKKDTVEVTKDAEKKSPGDTSGTPTTGTKKTVKKIIKRVVKRPVNDGKATGMKGEKSDVPEHVAIPETTVPKEESTGTSSNKKIVKKVAETGDTSDPSAKANEQTPAKTIVKKKIIKRVAKRKVAEIDNKMDGDSKKDGDSDEKKVMEVGKKSSDSGSVEMKPTAESLEDVKDENASKTVDVKQETGSPDTKKKEGASSSSKKDTKTGEDKKAEKKNNSETMSEGKKIDRNNTDEKEVKEKVTEKEIKERGGKDESRIQVKDRKKCEEPPRAGFILQTKRNKDSKLRSLSASLDSLLDYTDKDLDESSFEISLFAESLYEMLQYQMGSRIFEFLKKLRVKIVRQRNQRKRHQEELSVKQNEAKSQDKRQKTAEHEDKEASVISESAPGKDDKETSGKETVDGSREIADKEAVAKTKETLGSKEVTVGEAVNMEVENQDEEDDDGDDDPEEDPEEDPEEDPEEDPEEDPEECEEMDVANTEQEEPAEEPQKKEENLEKTSGTVADPITEAETDNRKEERGPNDSKTEIKPKSETEKHGKQDGGTSDAAKREETVDKELLQAFRFFDRNQAGYVRVEDMRVTIHSLGKFLSHREVKELVQSALLESNTGRDDRILYNKLVRLSL
Protein: Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) (O08725)
Organism: Rattus norvegicus (Rat)
Function: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Appetite-regulating hormone
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Somatostatin
- Pro-neuropeptide Y
- Membrane-bound ghrelin O-acyltransferase MBOAT4
- Somatoliberin
- Melanocortin receptor 3
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
Protein: GEO08372p1 (A1Z8H0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO07177p1
- Uncharacterized protein
- Protein dpy-30 homolog
- Lectin-33A
Sequence:
MRLTLLALIGVLCLACAYALDDSENNDQVVGLLDVADQGANHANDGAREARQLGGWGGGWGGRGGWGGRGGWGGRGGWGGRGGWGGGWGGRGGWGGRGGGWYGR
Protein: Isoflavone reductase homolog A622-like (NtA622L) (EC 1.3.1.-) (B6VRE6)
Organism: Nicotiana tabacum (Common tobacco)
Function: Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN). Reductase that may be involved in a late step of tobacco alkaloid biosynthesis. Maybe involved in either the formation of a nicotinic acid-derived precursor or the final condensation reaction of tobacco alkaloids.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P52580}.
Interaction partners:
Sequence:
MVVSEKSKILIIGGTGYIGKYLVETSAKSGHPTFVLIRESTLVNPEKSKLIDTFKSYGVTLLFGDISNQESLLKAIKQVDVVISTVGGQQFADQVNIIKAIKEAGNIKRFLPSEFGFDVDHAHAIEPAASLFALKVKIRRMIEAEGIPYTYVICNWFADFFLPNLGQLEAKTPPRDKVVIFGDGNPKAIYVKEEDIATYTMKAVDDPRTLNKTLHMRPPANILSFNEIVSLWEEKIGKTLEKLYLSEEDILHIVQEGPMPLRVNLAICHSVFVNGDSANFEIQPSTGVEATELYPKVKYTTVDEYYNKFV
Protein: Sex-determining region Y protein (Testis-determining factor) (P36394)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (By similarity). Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q05066}. Cytoplasm {ECO:0000269|PubMed:16488877}. Nucleus {ECO:0000269|PubMed:16488877}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization. Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus. Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH). {ECO:0000250|UniProtKB:Q05066, ECO:0000250|UniProtKB:Q05738}.
Interaction partners:
- POU domain protein
- Steroidogenic factor 1
- Muellerian-inhibiting factor
- Homeobox protein NANOG
- Zinc finger protein 1, Y-linked
- Eukaryotic translation initiation factor 2 subunit 3, Y-linked
- Forkhead box protein L2
- Transcription factor 4
- RBMY
Sequence:
MEGHVKRPMNAFMVWSRGERRKLAQQNPSMQNSEISKHLGYQWKSLTEAEKRPFFQEAQRLKTLHREKYPNYKYQPHRRVKVPQRSYTLQREVASTKLYNLLQWDNNLHTIIYGQDWARAAHQSSKNQKSIYLQPVDIPTGYPLQQKQQHQQQQHVHLQQQQQQQHQFH
Protein: Inclusion membrane protein E (P0DJI4)
Organism: Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx)
Function: Inclusion membrane protein probably involved in early modification events of the chlamydial inclusion.
Subcellular location: Secreted {ECO:0000250|UniProtKB:B0B9M4}. Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole membrane {ECO:0000250|UniProtKB:B0B9M4}; Multi-pass membrane protein {ECO:0000255}. Note=Secreted, probably by a type III secretion system (By similarity). Localized in the inclusion membrane (By similarity). {ECO:0000250|UniProtKB:B0B9M4}.
Interaction partners:
- Inclusion membrane protein F
- Inclusion membrane protein D
- Inclusion membrane protein G
- IncA family protein
- Inclusion Membrane Protein C
- IncA family protein
Sequence:
MECVKQLCRNHLCLDSLTGPVRSVLTQGTTAEKVQLVVSCLGVVCSIICLALGIAAAAVGVSCSGFAIGLGVIAILLGIVLFAISALDVLEDHGLVGCPFKLPCKSSPANEPTVQFFKGKNGSADKVILVTQ
Protein: Pseudouridylate synthase 7 homolog (EC 5.4.99.-) (Q96PZ0)
Organism: Homo sapiens (Human)
Function: Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types.
Subcellular location: Nucleus {ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:35144859}.
Interaction partners:
- Pseudouridylate synthase 1 homolog
- Pseudouridylate synthase TRUB1
- Pseudouridylate synthase RPUSD2
- tRNA pseudouridine
- RNA cytosine C
- Pseudouridylate synthase RPUSD4, mitochondrial
- Mitochondrial mRNA pseudouridine synthase RPUSD3
- Nucleolar complex protein 3 homolog
- Protein MAK16 homolog
- H/ACA ribonucleoprotein complex subunit DKC1
Sequence:
MEMTEMTGVSLKRGALVVEDNDSGVPVEETKKQKLSECSLTKGQDGLQNDFLSISEDVPRPPDTVSTGKGGKNSEAQLEDEEEEEEDGLSEECEEEESESFADMMKHGLTEADVGITKFVSSHQGFSGILKERYSDFVVHEIGKDGRISHLNDLSIPVDEEDPSEDIFTVLTAEEKQRLEELQLFKNKETSVAIEVIEDTKEKRTIIHQAIKSLFPGLETKTEDREGKKYIVAYHAAGKKALANPRKHSWPKSRGSYCHFVLYKENKDTMDAINVLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKITAQRLAHLNKCLMNFKLGNFSYQKNPLKLGELQGNHFTVVLRNITGTDDQVQQAMNSLKEIGFINYYGMQRFGTTAVPTYQVGRAILQNSWTEVMDLILKPRSGAEKGYLVKCREEWAKTKDPTAALRKLPVKRCVEGQLLRGLSKYGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNNMVSKRIEDYGLKPVPGDLVLKGATATYIEEDDVNNYSIHDVVMPLPGFDVIYPKHKIQEAYREMLTADNLDIDNMRHKIRDYSLSGAYRKIIIRPQNVSWEVVAYDDPKIPLFNTDVDNLEGKTPPVFASEGKYRALKMDFSLPPSTYATMAIREVLKMDTSIKNQTQLNTTWLR
Protein: Endoglin (Osler-Rendu-Weber syndrome 1) (Q5T9B9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTREYPRPPQ
Protein: Uracil phosphoribosyltransferase homolog (E9PSD7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFSADRLIRLVVEEGLNQLPYKECMVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD
Protein: Protein RADIALIS-like 2 (AtRL2) (Protein RAD-like 2) (Protein MATERNAL EFFECT EMBRYO ARREST 3) (Protein RADIALIS-LIKE SANT/MYB 1) (Protein RSM1) (Q9SIJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor. Required for female gametophyte development.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Carotenoid cleavage dioxygenase 8, chloroplastic
- Protein HEAT STRESS TOLERANT DWD 1
- Carotenoid cleavage dioxygenase 7, chloroplastic
- Cytochrome P450 711A1
- F-box protein MAX2
- Beta-carotene isomerase D27, chloroplastic
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD2
- Strigolactone esterase D14
- Protein SUPPRESSOR OF MAX2 1
- Probable esterase KAI2
Sequence:
MASGSMSSYGSGSWTVKQNKAFERALAVYDQDTPDRWHNVARAVGGKTPEEAKRQYDLLVRDIESIENGHVPFPDYKTTTGNSNRGRLRDEEKRMRSMKLQ