wanglab/gogpt-training-data huggingface dataset:
Protein: CDGSH iron-sulfur domain-containing protein 1 (Cysteine transaminase CISD1) (EC 2.6.1.3) (MitoNEET) (Q9NZ45)
Organism: Homo sapiens (Human)
Function: L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate. The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine). The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate. The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect. Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in iron-sulfur cluster shuttling and/or in redox reactions. Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:17376863, ECO:0000269|PubMed:17766439, ECO:0000269|PubMed:17905743, ECO:0000269|PubMed:18047834}; Single-pass type III membrane protein {ECO:0000269|PubMed:17376863, ECO:0000269|PubMed:17766439, ECO:0000269|PubMed:17905743, ECO:0000269|PubMed:18047834}.
Interaction partners:
- CDGSH iron-sulfur domain-containing protein 3, mitochondrial
- Non-selective voltage-gated ion channel VDAC1
- E3 ubiquitin-protein ligase parkin
Sequence:
MSLTSSSSVRVEWIAAVTIAAGTAAIGYLAYKRFYVKDHRNKAMINLHIQKDNPKIVHAFDMEDLGDKAVYCRCWRSKKFPFCDGAHTKHNEETGDNVGPLIIKKKET
Protein: Ghrelin [Cleaved into: Ghrelin-23; Ghrelin-24] (Q76IQ4)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Ligand for growth hormone secretagogue receptor type 1 (GHSR). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity). Induces the release of growth hormone from the pituitary.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MPLKRNTGLMILMLCTLALWAKSVSAGSSFLSPSQKPQVRQGKGKPPRVGRRDIESFAELFEGPLHQEDKHNTIKAPFEMGITMSEEEFQEYGAVLQKILQDVLGDTATAE
Protein: Glutamyl-tRNA reductase (GluTR) (EC 1.2.1.70) (P0A6X1)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). In the absence of NADPH, exhibits substrate esterase activity, leading to the release of glutamate from tRNA.
Interaction partners:
- Porphobilinogen deaminase
- Glutamate-1-semialdehyde 2,1-aminomutase
- Delta-aminolevulinic acid dehydratase
- Glutamate--tRNA ligase
- Uroporphyrinogen decarboxylase
- Uroporphyrinogen-III synthase
- Ferrochelatase
- Peptide chain release factor RF1
- Oxygen-dependent coproporphyrinogen-III oxidase
- Siroheme synthase
Sequence:
MTLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEEQDNLQEALIRWLCDYHNLNEEDLRKSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLARQIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERLREADIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRKAAAVEAETIVAQETSEFMAWLRAQSASETIREYRSQAEQVRDELTAKALAALEQGGDAQAIMQDLAWKLTNRLIHAPTKSLQQAARDGDNERLNILRDSLGLE
Protein: Protein ERP3 (Q12403)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in vesicular protein trafficking.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Endosomal protein P24B
- Endoplasmic reticulum vesicle protein 25
- Protein ERP6
- Protein ERP5
- Protein ERP1
- Regulator of rDNA transcription protein 6
- Pre-mRNA-processing protein 45
Sequence:
MSNLCVLFFQFFFLAQFFAEASPLTFELNKGRKECLYTLTPEIDCTISYYFAVQQGESNDFDVNYEIFAPDDKNKPIIERSGERQGEWSFIGQHKGEYAICFYGGKAHDKIVDLDFKYNCERQDDIRNERRKARKAQRNLRDSKTDPLQDSVENSIDTIERQLHVLERNIQYYKSRNTRNHHTVCSTEHRIVMFSIYGILLIIGMSCAQIAILEFIFRESRKHNV
Protein: GH10714p (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform B) (Uncharacterized protein, isoform C (EC 1.1.1.300)) (Uncharacterized protein, isoform D) (Q9W404)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- N-alpha-acetyltransferase 20
- Major facilitator superfamily transporter 18
- Sideroflexin-1-3
Sequence:
MSEAATPPGSVPGTVFPPGFDPTAESVEKTLCFRGFWAWAVLIFLIVLGILLFMWLLRKCIQGPAYRKANRIDGKVVIVTGCNTGIGKETVLELAKRGARVYMACRDPGRCEAARLDIMDRSRNQQLFNRTLDLGSLQSVRNFVERFKAEESRLDILINNAGVMACPRTLTADGFEQQFGVNHLGHFLLTNLLLDRLKHSSPSRIVVVSSAAHLFGRINREDLMSEKNYSKFFGAYSQSKLANILFTLKLSTILKDTGVTVNCCHPGVVRTEINRHFSGPGWMKTALQKGSLYFFKTPKAGAQTQLRLALDPQLEGSTGGYYSDCMRWPLFPWVRNMQTADWLWRESEKLLGLPPLEPPPPVQSPTQNGNGTQNGNGSSSASASASSNNPASREMQSVETVVVNRS
Protein: Cyclic nucleotide-gated cation channel subunit A (Cyclic nucleotide-gated ion channel subunit A) (CNG channel) (Q24278)
Organism: Drosophila melanogaster (Fruit fly)
Function: Approximately 50-fold more sensitive to cGMP than to cAMP. May be involved in transduction cascades of both invertebrate photoreceptors and olfactory sensillae.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cyclic nucleotide-gated ion channel subunit B, isoform A
- Cyclic nucleotide-gated ion channel-like, isoform E
- AT10229p
- Uncharacterized protein, isoform E
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1
Sequence:
MRHFKVKAMVQSLDISAITGQQTDAEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLEMNGGPGTWRLECEPQSRARSGRLYSLQPKRRPRSRPDATAKSSDAAKQNTL
Protein: Protein lines (Q9V4Z9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has a dual role as a segment polarity protein and as a modulator of the Abd-B protein. Required for Abd-B to activate the transcription of genes (including ems, cut and sal) that are involved in posterior spiracle morphogenesis. Also required for Abd-B to form an eighth abdominal denticle belt. Acts in a hierarchy downstream of drm and upstream of bowl during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Required to regulate expression of embryonic hindgut patterning genes in order to establish the large intestine and at least some rectum, and to repress small intestine fate. Required for late wingless (wg)-dependent cell fate specification in the dorsal embryonic epidermis. Acts in concert with wg to regulate expression of wg itself and also to regulate wg-target genes. May have a role in ventral epidermal patterning, independent of wg signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10837029}. Nucleus {ECO:0000269|PubMed:10837029}. Note=Cytoplasmic in the half of the parasegment, posterior to the engrailed (en) domain, and nuclear in the half of the parasegment anterior to the en domain.
Interaction partners:
- Protein unc-119 homolog
- Protein drumstick
- Protein bowel
Sequence:
MDTSSAAGSGAGTGDVCPCSTVATSTTSASNEQPQTKRQKIEQQIKVGSKALPPQPPHPPDILDLDANSNSHLCSSLSSSSSHSLSTPSTANNSPTTTPCSSRAASYAQLLHNILPQNGDTDLHSQPESAHDEVDRAAKLPNLLTLDTTNGNGSHASSRSNCLQATTATSIDDMLEFEQSLTRQCLCGVSERTLRKPFQSHYSQDTNGQKRIAYLREWPTNKLLQFLSNLQLLFDIYLKQNAKGFICTRIMDVCDALIRNDHKLIDEIIVLAGYENSYVQFLAGRVLAAFLVIAKQELNDEWLQKIVDQLFNFEQLDQAAVQKIHFSLDIIKRIVEWKDMEIHPLDDDWMASANSTSAASSVVPLSTEASVSYMHFPVQEQPLATNYFALQFREDTEGERETGQEAPDNRDRHRRHFGEDMNVAYEPHPAPQSTTMPSGCHVVTLTDSESFDTTHLKCITIQKLEHKWPTLVKNMSELMAPTHQDAAEHCVLNFLQLWENIISVKANLSIDETRPYYAQLDKFELLLSHSLSCTVYKQMLCLFNEALCYGSTLALQDMLPEETCKLAHQIVCHVRGFRILESLPRRQPDNMVSLIGYNGKPMVYANGTITLAHAAQSGDSEEDGAPLDLIEMDKTLLQKMVLLVLKSIAVTVKEIRSDSSDSSIDSTDYDAFQDMMLIERSIRDVLSKLETFIKQTLEFHPECHFSKILIHLFDDQDDHLIEAMVCTLDVTSGISFRNNAFPELVAMLNPVYTFLEFLKMTSNSSDLLLDLLVSNETCFLLYLLRLLKYIRMNWTMFVHSCHTFGMGSAMLDEAMGVLIRLRLQISRLVSRQLYPYDISPVLRLLESCESLYEGNELS
Protein: rRNA-processing protein FCF1 homolog (Q9Y324)
Organism: Homo sapiens (Human)
Function: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
Interaction partners:
- WD repeat-containing protein 46
- KRR1 small subunit processome component homolog
- Ribosomal RNA small subunit methyltransferase NEP1
- Probable U3 small nucleolar RNA-associated protein 11
- Deoxynucleotidyltransferase terminal-interacting protein 2
- Something about silencing protein 10
- Nucleolar protein 58
- U3 small nucleolar ribonucleoprotein protein IMP3
- Small subunit processome component 20 homolog
- Ribosome biogenesis protein BMS1 homolog
Sequence:
MGKQKKTRKYATMKRMLSLRDQRLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRIAKDPRFERLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYISNHRYNIERMPDDYGAPRF
Protein: SET domain-containing protein (Q57XC0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLQQLSAHMCINVPRSSSAFAFILILLIGIMDPSQEGAEYLTAVFAKLGVPCRVANTVEKGKHILATADMPAQYSVFEEAPVVSWPSQGYLTLGVPFCLFCLRQRNNADIADEGEHNWNSCAGCGSLFCSESCLASAEMPHRVLCGVLQELRKRECTDGCCRPITKESLANCVAWVVGRIAGAIKQRQFSGKLLEENHRENANSISRQLFHVVTAPFNRFLDAPKNAEFADVDANSWYEEIDKLLREPCRAVLLQSAAAPPSIGADWALEIVDGLLRHDTLERFLGILTLNSQGLNGFVAVPGAAGDMDSPSLPITWVLKGGGIYSLQSAFNHSCVPNVAVLAEGGTHDITLRTLRAIKNGEELTITYIPVENTTRAERQMKLEGYFFTCRCPLCEEEE
Protein: Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) (Q8CHP0)
Organism: Mus musculus (Mouse)
Function: Required for the export of polyadenylated mRNAs from the nucleus (By similarity). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage.
Subcellular location: Nucleus {ECO:0000269|PubMed:16115198}.
Interaction partners:
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 3
- Pre-mRNA 3'-end-processing factor FIP1
- Cleavage and polyadenylation specificity factor subunit 1
- Cleavage and polyadenylation specificity factor subunit 5
- Cleavage stimulation factor subunit 2
- Symplekin
- Cleavage stimulation factor subunit 1
- Pre-mRNA cleavage complex 2 protein Pcf11
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Sequence:
MEEKEQLRRQIRLLQGLIDDYKTLHGNGPALGNSSATRWQPPMFPGGRTFGARYSRPSRRGFSSHHGPSWRKKYSLVNQPVESSDPASDPAFQTSLRSEDSQHPEPQQYVLERQVQLSPDQNMVIKIKPPSKSGAINASGVQRGSLEGCDDPSWSGQRPQGSEVEVPGGQLQPARPGRTKVGYSVDDPLLVCQKEPGKPRVVKSVGRVSDSSPEHRRTVSENEVALRVHFPSVLPHHTAVALGRKVGPHSTSYSEQFIGDQRANTGHSDQPASLGPVVASVRPATARQVREASLLVSCRTSKFRKNNYKWVAASEKSPRVARRALSPRTTLESGNKATLGTVGKTEKPQPKVDPEVRPEKLATPSKPGLSPSKYKWKASSPSASSSSSFRWQSEAGSKDHTSQLSPVPSRPTSGDRPAGGPSSLKPLFGESQLSAYKVKSRTKIIRRRGNTSIPGDKKNSPTTATTSKNHLTQRRRQALRGKNSPVLRKTPHKGLMQVNRHRLCCLPSSRTHLSTKEASSVHMGIPPSNKVIKTRYRIVKKTPSSSFGAPSFPSSLPSWRARRIPLSRSLVLNRLRPAITGGGKAPPGTPRWRNKGYRCIGGVLYKVSANKLSKTSSRPSDGNRTLLRTGRLDPATTCSRSLASRAIQRSLAIIRQAKQKKEKKREYCMYYNRFGRCNRGECCPYIHDPEKVAVCTRFVRGTCKKTDGSCPFSHHVSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKCKKKHTLLCPDFARRGICPRGSQCQLLHRNQKRHGRRTAAPPIPGPSDGAPRSKASAGHVLRKPTTTQRSVRQMSSGLASGAEAPASPPPSPRVLASTSTLSSKATAASSPSPSPSTSSPAPSLEQEEAVSGTGSGTGSSGLCKLPSFISLHSSPSPGGQTETGPQAPRSPRTKDSGKPLHIKPRL
Protein: Wiscott-Aldrich syndrome protein (Q9GSG9)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Actin-related protein 2
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 1
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 4
- Rho GTPase-activating protein gacF
- SH3 domain-containing protein
- WH2 domain-containing protein
Sequence:
MGSPTISDQEKSQVAFIAGSSSDIHSTTVARLYEGRQGRWEFMAVGIVSVVSNRVDKTNYIKVFDLKANYRIIFEQEIYDTFEFQKQRDFFFAFEGDSCVYGLSFADVTEAAEFYGQLLNCKQGNIGKTAAINPNTSSTKITASTPAPKVEKKKEKKGFMSKFFSSEEKDLEISAPTNFKHESHIGWDPENGFDIKNIPPDWRKLFQSAGIKKSELKNAETAQFIVNIIGEQMVGGSAPPPTQPGRSAPPAPPSSNQPGRSAPPPPPSVGKSAPPPPPPSHKTPAAPPSGGGAPPPPPPPPPPSSGPPPPPPPMASAPPSSGGGGASGGGRNDLLASIRSGASLKAVDKTNPLPDIQSLGNEGSRSLADTLAAAMANRRGGMREDDEEDDDDDDEWSDY
Protein: Acyl-coenzyme A oxidase acox-1.3 (EC 1.3.3.-) (O62138)
Organism: Caenorhabditis elegans
Function: Involved in the first step of peroxisomal beta-oxidation by catalyzing the desaturation of fatty acid-derived side chains of ascaroside pheromones, which regulates development and behavior. Specifically, shortens ascarosides with a 7-carbon side chain (asc-C7). Does not catalyze the desaturation of fatty acids or hydroxylated fatty acids. Involved in the biosynthesis of asc-C6-MK (daumone 2) and asc-delta-C9 (daumone 3) but not asc-C7 (daumone 1); daumones are pheromones produced during unfavourable growth conditions which promote entry into the dauer stage.
Subcellular location: Peroxisome {ECO:0000250|UniProtKB:O62140}.
Interaction partners:
- MaoC-like domain-containing protein
- SCP2 domain-containing protein
- Non-specific lipid-transfer protein-like 2
- Acetyl-CoA C-acetyltransferase
- Enoyl-CoA Hydratase
- Acetyl-coenzyme A synthetase
- Probable 3-ketoacyl-CoA thiolase
- 3-ketoacyl-CoA thiolase
- Acetyl-CoA acetyltransferase homolog, mitochondrial
- Ethylmalonyl-CoA decarboxylase
Sequence:
MSSICKGDNSDLTEERKNATFDTDKMAAVIYGREEIASRRRQLTESISRIHELAESKPLVFMTREEKIAESCRKLEVLSRHWNQTPFNRDNEEDALHIYREVLGMEGHPLALHDTMFIPTLVAQASQEQQEKWLGRARRKEIIGCYAQTEMGHGTNLRKLETTATYSPDTQEFILNTPTITALKWWPGALGKSSNNAIVVANLLIKDQNYGPHPFMVQLRDEKTHIPLKGIVVGDIGPKMAFNGADNGYLGFNNHRIPRTNLLMRHTKVEANGTYIKPSHAKIGYSSMVKVRSRMAMDQGLFLASALVIAVRYSAVRRQGFLEDKTQKVKVLDYQTQQHRLFPSLARAYAFIFTGFETIHLYSQLLKDVDMGNTSGMADLHALTSGLKSVVTHQTGEGIEQARMACGEHGYSMASYISEIYGVAIGGCTYEGENMVMLLQLARYLVKSVELIKSGEEKKLGPMVSYLAAKGGHPDLSSLNGYVTAFEHMARRQAWKATEKFLKLMETGESREVAWNKSAVELTRASRLHTRLFIIEAFMRRVSRIEDIPVKEVLTDLLHLHVNYELLDVATYALEFMSSTQLDYIRDQLYLYLEKIRPSAVSLVDSFQISDMQLRSVLGRRDGNVYENLFKWAKSSPLNKSDVLPSVDKYLKPMMEKAKL
Protein: Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) (P08133)
Organism: Homo sapiens (Human)
Function: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
Subcellular location: Cytoplasm {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Interaction partners:
- Prolow-density lipoprotein receptor-related protein 1
- Annexin A2
- Dysferlin
- Tripartite motif-containing protein 72
- Caveolin-3
- Annexin A1
- Protein kinase C alpha type
- Transcription factor p65
Sequence:
MAKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFLKALLALCGGED
Protein: Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) (Kinase induced by depolarization) (Protein kinase Kid-1) (O70444)
Organism: Rattus norvegicus (Rat)
Function: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKVYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGMAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWMLGTEGSVPENCDLRLCALDTDDGASTTSSSESL
Protein: Torsin (Q9XXG5)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004319, ECO:0000256|PIRNR:PIRNR038079}.
Interaction partners:
- Nuclear envelope phosphatase-regulatory subunit 1 homolog
Sequence:
MFLKCLFYTCCGETDIFNYHALYKDFDNKIFGQHLMAESVVHSIKSHWHNEHSQKPLVLSFHGGTGTGKNYVTEIIVNNTYRSGMHSPFVNYFVATNNFPNKKYIEDYKLELKDQLIRSARRCQRSIFIFDETDKLQSELIQVIKPFLDYYPAVFGVDFRKTIFIFLSNKGSKEIANIALEHHENGKIRSQLELKHFERTLMLSAFNEEGGLRNTDMISNQLIDHFIPFLPLSKFYVSQCIQVHLRKRGRHDLAKDGEFMQRVLDSLEFFPESSKIFSSSGCKRVNAKTDLEISKMGFSLNSKKEFNDEL
Protein: KxDL domain-containing protein (O01488)
Organism: Caenorhabditis elegans
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- BLOC-1-related complex subunit 6 C-terminal helix domain-containing protein
- BLOC-1-related complex subunit 8 homolog
- SNAPIN protein homolog
- Tropomyosin isoforms a/b/d/f
- BLOC-1-related complex subunit 7
- BLOC-1-related complex subunit 5
- Proteasomal ubiquitin receptor ADRM1 homolog
- ADP-ribosylation factor-like protein 8B
Sequence:
MAEKNHQQQERLPGNPFFPSRSNAGSSFDMPETPHLIDSLTSQIDEFTIQSIIDTQRQSLKRFEKTNEMLMNCAQLGDRRIEKAKRDSVGHKETILQMKTDLEFIFKKIRMFKTVLSSKYPEVYAEVSAELTPKRSEEDE
Protein: Shadow of prion protein 2 (Sho2 protein) (Q65CB0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Prion protein b.
- Prion protein a.
- Ubiquitin-conjugating enzyme E2Ka
Sequence:
MLGNQKLLIIWVWMLLLASLCPCFHCKRGFGGRGMSKGAAPAKAPPSQSKGSSSRQGLKLAGAAAAGAIGGAAIGYGLGSLGRPRYGHNGYSDGYHQPVYNQSHRGYYGSTGSSEHMGSLLITLGTVAHVVIMWA
Protein: Uncharacterized protein (Q383J1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Acyl carrier protein
- Electron transfer protein, putative
Sequence:
MPALRPPMLENHALVVAALAMSFPSPHVSSLILLFFSPEMLRRTLSRCFSADAIGPVHPDVMWGYMDARYAGPGWVSWIKQLPVETLTMQGGTSMTNMNDRTGVIADPEDPRHPIALIQWGPMNHYDGAFMQLSYGDYGPISQGSRLMQVLYDNYLEPFSMNRVCAQLYFYQKVPNNYHESVEASAEYIGQTASLIGQVLVGMGSVIMEGVTVKGDTNCVYIAEGVQVLENTCIVSDAPTDLLAYQRHEAINPYQQWDGMDGVCRIMQNTIIEPNCFLDSCSIGPFNRIGHNTKIMKGVTTGTMVHILPGSVVTKDTKIGDGELWGGAPAVKIGKVSKFEWKRPYFASLLHRESVVESYRNMSRYGDQVVHFQDKMGKLDTLMLQYEKDVPASVKAKIKEFVQGREPFHHMLTRITQGWSPANRPDDKNYNLCPPLPGVKLFAEHNNDSSDSDLHGTYMDITNIFNDFRW
Protein: Protein kinase C and casein kinase substrate in neurons 2 (Protein kinase C and casein kinase substrate in neurons protein 2 isoform X1) (A0A0R4IHF0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004599}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004599}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004599}. Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004180}. Early endosome {ECO:0000256|ARBA:ARBA00004412}. Membrane, caveola {ECO:0000256|ARBA:ARBA00004345}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004565}.
Interaction partners:
Sequence:
MSDFNDSLIDVSSDSFWEVGNYKRSVKRVDDGNRLCNDLMSCLHERARIEKSYSTQLTDWAKRWRQTIEKGPQYGTVERAWCALMTEAEKVSDLHMEVKAALMAEDFEKIKNWQKDAYHKQMIGGFKETKEAEDGFRKAQKPWAKKLKEMETMKKAYHTACKEEKTATSRENSSKLDNSNPEAQKKLQEKVEKCQQEVQKTKERYEKSLEDLDKVTPQYMENMEQVFEQWQQFEGKRLSFFKEVLLEVKQHLDLSSNHKYTTVYHTLQDTIQGADPQEDLKWFRSNHGPGMTMNWPQFEEWSMDLNRTLSRRETKRRPAEGVTLTAISHNPEQSSRVSSVPAVSSSEAACLNPFDDDDDDEDEDEEPVVTHTHSSPVKHEEAVAQTSAAVEKAPAPAAITAADDDDDEESGNPFSSSSANGNPFEEEPSTEMCVPVRAVYDYEGQEQDELSFKAGDELVKLSEEDEQGWCKGRLSNGTVGLYPANYVEDLQ
Protein: Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (P68) (P70) (Protein III) (P51901)
Organism: Gallus gallus (Chicken)
Function: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Melanosome {ECO:0000250}.
Interaction partners:
Sequence:
MAPKGKVYRGSVKDFPGFNASQDADALCNAMKGFGSDKDAILDLITSRSNKQRLEICQAYKSQYGKDLIADLKYELTGKFERLIVSLMRPPAYSDAKEIKDAIAGIGTDEKCLIEILASRTNQEIHDLVAAYKDAYERDLEADVVGDTSGHFKKMLVVLLQGAREEDDVVSEDLVEQDAKDLLEAGELKWGTDEAQFIYILGRRSKQHLRMVFDEYLKISGKPIERSIRAELSGDFEKLKLAVVKCVRSTAEYFAERLYKAMKGLGTRDNTLIHIMVSRSEIDMLDIREVFRTKYDKSLHNMIKEDTSGEYKKALLKLCEGDDDAAAEFFPEAAQVAYRMWELSAVAKVELRGTVQPASNFNDDGDAQVLRKAMKGLGTDEGAIIEVLTQRSNAQRQQILKAYKAHYGRDLLADLKSELSGSLANLILGLMLTPAQYDAKQLRKAVEGDGTDESTLVEIMATRNNQEIAAINEAYQQAYHKSLEDDLSSDTSVHFKRLLVSLALGNRDEGPENLTQAHEDAKVVAETLKLADVPSNDSSDSLETRFLSILCTRSYPHLRRVFQEFVKMTNHDVEHAIRKRMSGDVRDAFVAIVRSVKNKPAFFADKLYKSMKGAGTDERTLTRIMISRSEIDLLNIRGEFIDLFDKSLYQMIEKDSGDYCKALLALCGGDD
Protein: Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Q6R005)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14758365}; Peripheral membrane protein {ECO:0000269|PubMed:14758365}. Postsynaptic density {ECO:0000269|PubMed:14758365}. Synapse {ECO:0000269|PubMed:14758365}. Note=High levels in postsynaptic density of neuronal cells.
Interaction partners:
- Neuroligin 1
- Gephyrin
- Gephyrin
- Discs, large homolog 3
- ADAM metallopeptidase domain 22
- Neurexin-1a-beta
- Synapsin-1
- Tight junction protein 1a
- Disks large-associated protein 1
- SH3 and multiple ankyrin repeat domains 2b
Sequence:
MPLKREDTERALQAMEACQSAGDEGFRTRAERLLTIFQSDLFQALLDIQEFYELTVFENQTAGRALTPGLKYRYHDEETPPLQHSPAHLSTGKSAEMLHLGDSGHAPIDGIHAYTPQMHVSPAKPVLLPSGHAPYYATSTLMNGMDGDVEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNDVDVREVTHSFAVEALKEAGPIVRLYVLRHKPSAEKITELKLIKGPKGLGFSIAGGVGNQHVPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNNMYLEEVMHEDAVAALKNTGDVVFLRVAKTLHQHHHQDAYNPPDITSSYSPHMDMSDYPQALSPSSPRRYSPIPKGLFLDDDISREPRRVVIHRGSTGLGFNIVGGEDGEGIFISFILAGGAADLSGELRKGDQILSVNGVDLRHATHEQAAAALKNAGQTVTIITQYRPEEYSRFEAKIHDLREQLMNSSLVSAAASLRSGKRSFFIRALFDYDKTADGGFLSQAVSFRFGDVLQVFDCSDEEWWQAGKLAPHGELEETGYIPSKRRVERKEWSRLKTRGREPVSGRSDYIVSYETVTQSEVHYARPVIILGPSKDRVNDDLLSEFPDKFGSCVPHTTRPKREYEMDGRDYHFVSSREQMEKDIQSHRFIEAGQYNSHLYGTSVQSVRQVAEQQGKHCILDVSANAVRRLQAAQLYPIAIFIRPSSLQNVLNISKRLTEEQARRALDRAVKLEQDFIECFSAIVEGESFEEIYHHVKSVIEEQSGPYIWIPARERL