wanglab/gogpt-training-data huggingface dataset:
Protein: Protein shisa-7 (Cystine-knot AMPAR modulating protein of 59 kDa) (CKAMP59) (GABA(A) receptor auxiliary subunit Shisa7) (Shisa family member 7) (Q8C3Q5)
Organism: Mus musculus (Mouse)
Function: Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall (Probable). May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses (Probable).
Subcellular location: Postsynaptic density membrane {ECO:0000269|PubMed:29199957, ECO:0000269|PubMed:31601770}; Single-pass type I membrane protein {ECO:0000305|PubMed:29199957}. Note=Localizes at GABAergic inhibitory synapses and colocalizes with gephyrin in hippocampal neurons. {ECO:0000269|PubMed:31601770}.
Interaction partners:
- Protein shisa-2 homolog
Sequence:
MPALLLLGTVALLASAAGPAGARPSNDTSSVAPGPLPALLAHLRRLTGALAGGGSAAGTSANATKTSPASGTGAAARAPPPAELCHGYYDVMGQYDATFNCSTGSYRFCCGTCHYRFCCEHRHMRLAQASCSNYDTPRWATTPPPLAGGAGGAGGAGGGPGPGQAGWLEGGRAGGAGGRGGEGPGGSTAYVVCGVISFALAVGVGAKVAFSKASRAPRAHREINVPRALVDILRHQAGPATRPDRARSSSLTPGLGGPDSMAPRTPKNLYNTMKPSNLDNLHYNVNSPKHHAATLDWRAMPPPSPSLHYSTLSCSRSFHNLSHLPPSYEAAVKSELNRYSSLKRLAEKDLDEAYLKRRQLEMPRGTLPLHALRRPGTGGGYRMDGWGGPEELGLAPAPNPRRVMSQEHLLGDGSRASRYEFTLPRARLVSQEHLLLSSPEALRQSREHLLSPPRSPALPPDPTTRASLAASHSNLLLGPGGPPTPLHGLPPSGLHAHHHHALHGSPQPAWMSDAGGGGGTLARRPPFQRQGTLEQLQFIPGHHLPQHLRTASKNEVTV
Protein: Nucleosome assembly protein 1, like 1 (B5DGT6)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MADMDNKDQAELDPADLEDVEDVEEEETGEDVNSKVPGFVRLPSARQLTVQMMQNPQILAALQERLDGLVGSPSGYMESLPKVVKRRVNALKNLQVKCAHIEAKFYEEVHELERKYAALYQPLFDKRSDIVKAAYEPTEEECEWKADEEEELTVSKQEEMKEKAKVEEEKKDEEKEDPKGIPEFWLTVFKNVDLLSDMLQEHDEPILKHLQDIKVKFSDPGQPMSFSLEFYFEPNEFFTNTLLTKTYKMRSEPDENDPFSFDGPEIMGCTGCTIDWTKGKNITLKTIKKKQKHKGRGTVRTVTKTVPNDSFFNFFTPPDVPESGDLDEDSEAVLAADFEIGHFIRERIVPRAVLYFTGEAIEDDDDDYDEEGEEADDEEGEEEGEEENDPDYDPKV
Protein: Intermediate transcription factor 3 large subunit (VITF-3) (Q80HV2)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Acts with RNA polymerase to initiate transcription from intermediate gene promoters.
Interaction partners:
Sequence:
MDNLFTFLHEIEDRYARTIFNFHLISCDEIGDIYGLMKERISSEDMFDNIVYNKDIHPAIKKLVYCDIQLTKHIINQNTYPVFNDSSQVKCCHYFDINSDNSNISSRTVEIFEREKSSLVSYIKTTNKKRKVNYGEIKKTVHGGTNANYFSGKKSDEYLSTTVRSNINQPWIKTISKRMRVDIINHSIVTRGKSSILQTIEIIFTNRTCVKIFKDSTMHIILSKDKDEKGCIHMIDKLFYVYYNLFLLFEDIIQNEYFKEVANVVNHVLTATALDEKLFLIKKMAEHDVYGVSNFKIGMFNLTFIKSLDHTVFPSLLDEDSKIKFFKGKKLNIVALRSLEDCINYVTKSENMIEMMKERSTILNSIDIETESVDRLKELLLK
Protein: GATA-type zinc finger protein 1 (GATA-like protein 1) (GLP-1) (Q1WG82)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independently of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase.
Subcellular location: Nucleus {ECO:0000269|PubMed:16982049}.
Interaction partners:
Sequence:
MEAAQAGDLTRRQELLAPPCLDTESLRKSRPPALEPGALRCLTPNIRSLWPTCQDSVSTALPFLQEKEKGLPGSPSPATQVLGSCWELMVIGMSDHLSMARNPRGTQCPNLEISSATSPASLQRRPRKQLNPRMGIEKVDPRFKGVTLEFQIQPDSSLQIVPTYSLPGRSCSQKLPASPSKALASPGSSEALGPRRCASCRTQRTPLWRDAEDGTPLCNACGIRYKKYGTRCSSCWLVPRKSIQPKRLCGRCGMSQDPHLSPTQEL
Protein: Importin 7 L homeolog (MGC52556 protein) (RanBP7) (O42480)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDPNILIEALRGTMDPALREAAERQLNESHKSLHFVSTLLQITMSEQLELPVRQAGVIYLKNMITQYWPDREVTPGELPPHTIPEEDRHCIRENIVEAIMHSPELIRVQLTTCIHHIIKHDYPNRWTAVVEKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLIAAMQHFLPMLKDRYIQLLADPSEQSVLIQKQIFKIFYALVQYTLPLELINQQNLAEWIEILKTVVDRDVPAETLQVDEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNDFAEVFLKAFAVGVQQVLLKVLYQYKEKQYIAPRVLQQTLNYFNQGVSHAVTWKNLKPHIQGIIQDVIFPLMCYTDSDEDLWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTSCSKRKEVLQKTMGFCYQILTEPAADPRKKDGALHMIGSLAEILLKKKIYKDQMEFMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKVDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYIVPFIRPVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAHSLTCQQVSPQMWQLLPLVFDIFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYSMCKKILTGVAGEDAECHAAKLLEVVILQCKGRGIDQVIPLFVEAALERLTREVKTSELRTMCLQVAIAALYYSPPLLFNTLENLRFPNNEEPVTNHFIKQWLNDVDCFLGLHDRKICVLGLCALIELEQRPQVLNQMSSQILPAFLLLFNGLKRAYACHAEQENDSDDDGDGEDDEDAAELGSDEDDIDEEGQEYLEILAKQAGEDGDDEDWEDDDAEETALEGYTTLLDDEDTPIDEYQIFKAIFQKLQGRDPVWYQALTQGLNEDQGKQLQDIATLADQRRAAHESKMIEKHGGYKFNAPVVPSTFNFGNPAPGMN
Protein: Serine/threonine-protein kinase 1 (EC 2.7.11.1) (P41415)
Organism: Autographa californica nuclear polyhedrosis virus (AcMNPV)
Function: Serine/threonine protein kinase that plays a role in viral propagation by phosphorylating various viral and cellular substrates including the viral p6.9 protein or host histone H1. Participates in nucleocapsid assembly and polyhedra formation.
Interaction partners:
Sequence:
MATTNATLQTLVQFYENCKNVKTRYKIINGRFGKISILSHKPTSKLYLQKTISAHNFNADEIKVHQLMSDHPNFIKIYFNHGSINNQVIVMDYIDCPDLFETLQIKGELSYQLVSNIIRQLCEALNDLHKHNFIHNDIKLENVLYFEALDRVYVCDYGLCKHENSLSVHDGTLEYFSPEKIRHTTMHVSFDWYAVGVLTYKLLTGGRHPFEKSEDEMLDLNSMKRRQQYNDIGVLKHVRNVNARDFVYCLTRYNIDCRLTNYKQIIKHEFLS
Protein: Undecaprenyl-diphosphooligosaccharide--protein glycotransferase (EC 2.4.99.19) (Protein glycosylation B) (Q0P9C8)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Function: Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (GalNAc(2)GlcGalNAc(3)Bac(NAc)(2) in eubacteria, where Bac(NAc)(2) is di-N-acetyl bacillosamine) from the lipid carrier undecaprenol-pyrophosphate to an asparagine residue within an Asp/Glu-Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:20331969}; Multi-pass membrane protein {ECO:0000305|PubMed:20331969}.
Interaction partners:
- Protein translocase subunit SecY
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL22
Sequence:
MLKKEYLKNPYLVLFAMIVLAYVFSVFCRFYWVWWASEFNEYFFNNQLMIISNDGYAFAEGARDMIAGFHQPNDLSYYGSSLSTLTYWLYKITPFSFESIILYMSTFLSSLVVIPIILLANEYKRPLMGFVAALLASVANSYYNRTMSGYYDTDMLVIVLPMFILFFMVRMILKKDFFSLIALPLFIGIYLWWYPSSYTLNVALIGLFLIYTLIFHRKEKIFYIAVILSSLTLSNIAWFYQSAIIVILFALFALEQKRLNFMIIGILGSATLIFLILSGGVDPILYQLKFYIFRSDESANLTQGFMYFNVNQTIQEVENVDFSEFMRRISGSEIVFLFSLFGFVWLLRKHKSMIMALPILVLGFLALKGGLRFTIYSVPVMALGFGFLLSEFKAILVKKYSQLTSNVCIVFATILTLAPVFIHIYNYKAPTVFSQNEASLLNQLKNIANREDYVVTWWDYGYPVRYYSDVKTLVDGGKHLGKDNFFPSFSLSKDEQAAANMARLSVEYTEKSFYAPQNDILKSDILQAMMKDYNQSNVDLFLASLSKPDFKIDTPKTRDIYLYMPARMSLIFSTVASFSFINLDTGVLDKPFTFSTAYPLDVKNGEIYLSNGVVLSDDFRSFKIGDNVVSVNSIVEINSIKQGEYKITPIDDKAQFYIFYLKDSAIPYAQFILMDKTMFNSAYVQMFFLGNYDKNLFDLVINSRDAKVFKLKI
Protein: Coiled-coil domain-containing protein 92 (Limkain beta-2) (Q53HC0)
Organism: Homo sapiens (Human)
Function: Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22863007}. Cytoplasm {ECO:0000269|PubMed:32528005}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 8
- Proteasomal ubiquitin receptor ADRM1
- 26S proteasome regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 10
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 2
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome regulatory subunit 10B
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome regulatory subunit 8
Sequence:
MTSPHFSSYDEGPLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDASPSGSPVLASYKPAPPKDKLPETPRRRMKKSLSAPLHPEFEEVYRFGAESRKLLLREPVDAMPDPTPFLLARESAEVHLIKERPLVIPPIASDRSGEQHSPAREKPHKAHVGVAHRIHHATPPQAQPEVKTLAVDQVNGGKVVRKHSGTDRTV
Protein: Acetyl-coenzyme A thioesterase (EC 3.1.2.1) (Acyl-CoA thioester hydrolase 12) (Acyl-coenzyme A thioesterase 12) (Acyl-CoA thioesterase 12) (Cytoplasmic acetyl-CoA hydrolase 1) (CACH-1) (hCACH-1) (START domain-containing protein 15) (StARD15) (Q8WYK0)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes acetyl-CoA.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:16951743}.
Interaction partners:
- Acetyl-coenzyme A synthetase, cytoplasmic
- Acetyl-coenzyme A synthetase 2-like, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Acetyl-CoA acetyltransferase, cytosolic
- Acylphosphatase-1
- Acetyl-CoA carboxylase 1
- Aldehyde dehydrogenase X, mitochondrial
- Acylphosphatase-2
- Aldehyde dehydrogenase, mitochondrial
- 4-trimethylaminobutyraldehyde dehydrogenase
Sequence:
MERPAPGEVVMSQAIQPAHATARGELSAGQLLKWIDTTACLAAEKHAGVSCVTASVDDIQFEETARVGQVITIKAKVTRAFSTSMEISIKVMVQDMLTGIEKLVSVAFSTFVAKPVGKEKIHLKPVTLLTEQDHVEHNLAAERRKVRLQHEDTFNNLMKESSKFDDLIFDEEEGAVSTRGTSVQSIELVLPPHANHHGNTFGGQIMAWMETVATISASRLCWAHPFLKSVDMFKFRGPSTVGDRLVFTAIVNNTFQTCVEVGVRVEAFDCQEWAEGRGRHINSAFLIYNAADDKENLITFPRIQPISKDDFRRYRGAIARKRIRLGRKYVISHKEEVPLCIHWDISKQASLSDSNVEALKKLAAKRGWEVTSTVEKIKIYTLEEHDVLSVWVEKHVGSPAHLAYRLLSDFTKRPLWDPHFVSCEVIDWVSEDDQLYHITCPILNDDKPKDLVVLVSRRKPLKDGNTYTVAVKSVILPSVPPSPQYIRSEIICAGFLIHAIDSNSCIVSYFNHMSASILPYFAGNLGGWSKSIEETAASCIQFLENPPDDGFVSTF
Protein: Protein spire homolog 2 (Spir-2) (Q8K1S6)
Organism: Mus musculus (Mouse)
Function: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21983562}. Cytoplasm, cytosol {ECO:0000269|PubMed:21983562}. Cell membrane {ECO:0000269|PubMed:21983562}; Peripheral membrane protein {ECO:0000269|PubMed:21983562}; Cytoplasmic side {ECO:0000269|PubMed:21983562}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21983562}; Peripheral membrane protein {ECO:0000269|PubMed:21983562}; Cytoplasmic side {ECO:0000269|PubMed:21983562}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000269|PubMed:21620703}.
Interaction partners:
- Formin-2
- Unconventional myosin-Va
- Formin-1
- Ribosome quality control complex subunit TCF25
Sequence:
MARAGGGGAAAPERAGGAARPEPWELSLEEVLKVYEQPINEEQAWAVCFQGCRGLRGEPGGVRRIRDTADILLRRDGSVGARLEPEPTTMVVPPASSEAQMVQSLGFAIYRALDWGLDENEERELSPQLERLIDLMANSDCEDSSCGAADEGYVGPEEEEEAEGGPRAVRTFAQAMRLCALRLTDPHGAQAHYQAVCRALFVETLELRAFLARVREAKEMLKKLGEEEPREKPLAELDHLGHTDWARLWVQLMRELRHGVKLKKVQEKEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERQLRPVPQKQRTLHEKILEEIKQERRLRPVGAQHLGGRGFGSLPCILNACSGDIKSTSCINLSVTDTGSGSQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVALKRDRSFSEHDLAQLRSEMASGLQSAAQPPGGTEPPRARAGSMHSWRPSSRDQGFCPVSGQSQPLPSSALPSSLSSVDGPEAASPDTRHLWLEFSHPVESLALTVEEVVDVRRVLVKAEMERFLQDKELFSSLKRGKICCCCRAKFPLFSWPPTCLFCKRAVCTSCSVKMKMPSKKYGHIPVYTLGFESLQRVPTTKATPTLRRDAFQSLQGPKWRSVEEEFPHIYAHGCVLKDVCSDCTSFVADVVCSSRKSVDVLNATPRRSRQTQSLYIPNTRTLNFQ
Protein: Lymphotoxin-alpha (TNF-alpha) (TNF-beta) (Tumor necrosis factor) (Tumor necrosis factor ligand superfamily member 1) (Q1L8A5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- Tumor necrosis factor receptor superfamily, member 1a.
- Nuclear factor NF-kappa-B p105 subunit isoform X1
- Transcription factor Jun
- Tumor necrosis factor receptor superfamily member 1B precursor
- Transcription factor p65
- TNF superfamily member 18
- Interleukin-1.
- CD40 molecule, TNF receptor superfamily member 5
- Interferon gamma related precursor
- Interleukin family protein
Sequence:
MKLESRAFLDVEEGELPLPLVIVSRRKAGSSKSGVWRVFGIILAVGLCAAAAVCFTLHKTQGNQQDGSVLRLTLRDRISQGNFTSKAAIHLTGGYNSESKTLDWRDDQDQAFSSGGLKLVNREIIIPDDGIYFVYSQVSLHISCTSELTEEQVLMSHAVMRFSESYGGKKPLFSAIRSICTQEPESENLWYNTIYLGAAFHLREGDRLGTDTTTALLPMVENDNGKTFFGVFGL
Protein: Eukaryotic translation initiation factor isoform 4E (eIF(iso)4E) (Protein LOSS OF SUSCEPTIBILITY TO POTYVIRUS 1) (eIF-(iso)4F 25 kDa subunit) (eIF-(iso)4F p28 subunit) (eIF4Eiso protein) (mRNA cap-binding protein) (O04663)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Mediates susceptibility to Turnipmosaic potyvirus (TuMV) and Tobacco etch potyvirus (TEV).
Interaction partners:
- Eukaryotic translation initiation factor isoform 4G-1
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor isoform 4G-2
- Protein PIR
- Initiation factor eIF-4 gamma, MA3
- MIF4G domain-containing protein
- Polyadenylate-binding protein 2
- Nuclear cap-binding protein subunit 1
- Eukaryotic translation initiation factor 4E-1
- Basic transcription factor 3
Sequence:
MATDDVNEPLPAAAELPATEAEKQPHKLERKWSFWFDNQSKKGAAWGASLRKAYTFDTVEDFWGLHETIFQTSKLTANAEIHLFKAGVEPKWEDPECANGGKWTWVVTANRKEALDKGWLETLMALIGEQFDEADEICGVVASVRPQSKQDKLSLWTRTKSNEAVLMGIGKKWKEILDVTDKITFNNHDDSRRSRFTV
Protein: Autophagy protein 5 (Q54GT9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in autophagic vesicle formation. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and its association to the vesicle membranes (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Ubiquitin-like protein atg12
- Protein tipD
- Autophagy-related protein 3
- Autophagy-related protein 18
- Ubiquitin-like modifier-activating enzyme atg7
- Autophagy-related protein 8
- Serine/threonine-protein kinase atg1
- Probable serine/threonine-protein kinase vps15
- Autophagy-related protein 9
- Ubiquitin-like-conjugating enzyme ATG10
Sequence:
MSSFDEDIKRSIWEGKIPIVFTLSPDDLTSHLSPSPYTLMAPRNSYFPLITSLVKDYFSSSTLVLLDEMWLEYRGIPLKWHLPIGVLYDTIVGNNNCNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIIMEQPYWNIVVHFQSYPDRILLRCPNIESVRTYYKNVLKEANFIKQGDITKINNLNINQSNDLWDGLKSHDYDKFWSVNKKLIPNSNKEYKNIPIRLIINYKPPIQELIPVFDENLVELTLENLFSRIPYESFSNFLNYNNNNNNNNINNNSPPLSPNSNNNNNNNNVDNSIENSLNQTNVESAEPEFSNLLQYIKATNAEYKIQGIQPSLKSSAVWLYEHFGHPDNFLYIVLIDPSQNNNNNNNNSNNY
Protein: DNA polymerase kappa (Q384G0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA polymerase eta
- DNA polymerase
Sequence:
MCGGEENGGLDQAHVSYSGSASEQNIAEMIVDPSGSRQPTAFQLTLDCNKAGMGNVDKERVEAIIRNVSEGSSFLMNEQRLAEGREKQLQELKRKSSLFTQLLGGERNAAQRKQWELKVSKIEQELEATRRLGTYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTRLQTANYIARGRGVRCSMPGFLALKICPNLLILPPDFDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYIERFEGTKTAEDVASELRVRVFGDTKLTASAGIGPTAALAKIASNINKPNGQHDLNLHTREDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCYILHNNLFRFLLGASIGIVQWPDAATAANTENCEGATGGQRKAISSERSITTPRTKEGMQEMVDTVFNGAYEEMRKSELMCRRISLRIRWASYRYQQYTKSLIQYSDDSATLRRAVDGLLLPHAAKYSEISLLGVRFLDLIFAKDFHMKRKGGNQLSISQFIRPKKPGEVTATTGIKRERTTEPKQVVEIIISSDDEDENDSVGLASSSTILVSTDKGTVEREVTII
Protein: Replication protein A 70 kDa DNA-binding subunit A (AtRPA70A) (AtRPA1-3) (Replication factor A protein 1A) (Replication protein A 1A) (AtRPA1A) (Q9SKI4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Plays an essential role at later stages of meiotic recombination events required for the formation of class I crossovers. Is essential for normal progression through meiosis in pollen mother cells. Is involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses, but does not seem to be required for the repair of meiotic DSBs.
Subcellular location: Nucleus {ECO:0000269|PubMed:19153602}. Note=Associated with meiotic chromosomes from leptotene through to early pachytene.
Interaction partners:
- Replication protein A 32 kDa subunit B
- Replication protein A 32 kDa subunit A
- Replication protein A 70 kDa DNA-binding subunit D
- Replication protein A 70 kDa DNA-binding subunit B
- Replication protein A 70 kDa DNA-binding subunit C
- F5O8.30 protein
- F11M21.26 protein
- Nucleic acid-binding, OB-fold-like protein
- Expressed protein
- Uncharacterized protein At4g28440
Sequence:
MPVSLTPNAITAIHDGDVNLKPLLQVLEIKMIGRSQERSQERYRFLISDGVSAQHAMVAVQLNDRVKSGQFEKGSIVQLIDYICSDVKGRKLIVVLNMETIVQQSETIGNPTIFGETDTEAQKTFSGTGNIPPPNRVVFNEPMVQHSVNRAPPRGVNIQNQANNTPSFRPSVQPSYQPPASYRNHGPIMKNEAPARVIPIAALNPYQGRWAIKARVTAKGDIRRYNNAKGDGKVFSFDLLDYDGGEIRVTCFNALVDRFYDVTEVGKVYLISKGSLKPAQKNFNHLKNEWEIFLESTSTVELCPDEDGSIPKQQFSFRPISDIENAENNTILDVIGVVTSVNPSVPILRKNGMETHRRILNLKDESGKAVEVTLWGEFCNRDGRQLEEMVDSAFHPVLAIKAGKVSDFSGKSVGTISSTQLFINPDFPEAHKLRTWFDYGGKDTASFSISRDTMPGGVSRNEIRKNVSQIKEEGLGRSDKPDWITVKATISFIKTDSFCYTACPLMIGDKQCNKKVTRSGTNRWLCDRCNQESDECDYRYLLQVQIQDHTGLTWITAFQETGEEIMGCPAKKLYAMKYELEKEEEFAEIVRDRLFHQYMLKLKIKEESYGDEQRVKMTVVKVDKVNYTSESKYMLDLLVR
Protein: Probable calcium-binding protein CML18 (Calmodulin-15) (AtCaM-15) (Calmodulin-like protein 18) (Q9M8U1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor that modulates ion selectivity of NHX1.
Subcellular location: Vacuole {ECO:0000269|PubMed:16249341}.
Interaction partners:
- Sodium/hydrogen exchanger 1
- Probable calcium-binding protein CML49
- Probable calcium-binding protein CML48
- Sodium/hydrogen exchanger 3
- Sodium/hydrogen exchanger 4
- At1g73440
- At2g03740
- Probable calcium-binding protein CML47
Sequence:
MSCDGGKPAPAKLGDEQLAELREIFRSFDQNKDGSLTELELGSLLRSLGLKPSQDQLDTLIQKADRNNNGLVEFSEFVALVEPDLVKCPYTDDQLKAIFRMFDRDGNGYITAAELAHSMAKLGHALTAEELTGMIKEADRDGDGCIDFQEFVQAITSAAFDNAWG
Protein: CCR4-NOT transcription complex subunit 4 (EC 2.3.2.27) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) (RING-type E3 ubiquitin transferase CNOT4) (O95628)
Organism: Homo sapiens (Human)
Function: Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- CCR4-NOT transcription complex subunit 1
- Ubiquitin-conjugating enzyme E2 D2
- CCR4-NOT transcription complex subunit 2
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 9
- CCR4-NOT transcription complex subunit 8
- CCR4-NOT transcription complex subunit 7
- Probable ATP-dependent RNA helicase DDX6
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 6-like
Sequence:
MSRSPDAKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPYPEDPAVYKPLSQEELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFGKIHKVVINNSTSYAGSQGPSASAYVTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSYFLKNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKLLQELYKLNPNFLQLSTGSVDKNKNKVTPLQRYDTPIDKPSDSLSIGNGDNSQQISNSDTPSPPPGLSKSNPVIPISSSNHSARSPFEGAVTESQSLFSDNFRHPNPIPSGLPPFPSSPQTSSDWPTAPEPQSLFTSETIPVSSSTDWQAAFGFGSSKQPEDDLGFDPFDVTRKALADLIEKELSVQDQPSLSPTSLQNSSSHTTTAKGPGSGFLHPAAATNANSLNSTFSVLPQRFPQFQQHRAVYNSFSFPGQAARYPWMAFPRNSIMHLNHTANPTSNSNFLDLNLPPQHNTGLGGIPVAGEEEVKVSTMPLSTSSHSLQQGQQPTSLHTTVA
Protein: Beta-alanyl-dopamine/carcinine hydrolase (EC 3.5.1.-) (NBAD/carcinine hydrolase) (Protein tan) [Cleaved into: Beta-alanyl-dopamine/carcinine hydrolase alpha subunit; Beta-alanyl-dopamine/carcinine hydrolase beta subunit] (Q9W369)
Organism: Drosophila melanogaster (Fruit fly)
Function: In the cuticle, catalyzes the hydrolysis of beta-alanyl-dopamine releasing dopamine and beta-alanine; dopamine is a metabolite involved in the pigmentation and sclerotization of the insect cuticle. In the photoreceptor cells, catalyzes the hydrolysis of carcinine releasing histamine and beta-alanine contributing to the recycling of the neurotransmitter histamine in the optical nerve system. Also, regulates the cuticular hydrocarbon composition in females.
Subcellular location: Cell projection, axon {ECO:0000269|PubMed:17154266}. Cytoplasm {ECO:0000269|PubMed:17154266}. Note=Localizes to the narrow axons and expanded terminals of R1-R6 in the lamina and of R7 and R8 in the medulla. {ECO:0000269|PubMed:17154266}.
Interaction partners:
- Argininosuccinate synthase
- Argininosuccinate lyase, isoform B
- Arginase
- Delta-1-pyrroline-5-carboxylate synthase
- FI01460p
- Multifunctional protein r
- Cuticular protein 72Ec
Sequence:
MSSGKILPRRQAVPVLYTRGTHYEVGFDMGRTFGSMIKNFLILSKPLNETYLPLYQSPKGRQIYNETLGSVKDSFPQYVRELEGVADGAEVEFHKLFLLHLDEILPQALKHQPRSKNQPTGCSTIIVNQKNCRLLGHTEDALTETLNHYYFVVAHIISDKPQGKYNVKEEHFMSLCYAGHLPGYTMSHNHHGLVFSINTISAELLRSGKTPRHFITRALLATSNVDDAFRVLKDAGVGAADACSINFTFLADPRQMCYNVEMAPSPDRKNESHLNIKEVPLGEHNYHVNQFDRIRQDQANDLMISSSISRMQTFGAYNPPMSEQDVRHMLGDVSGGVYCVWRENNSCDEVVKTIAVGIFDLSARTISLYSDNPSETEPHCRLPLLYK
Protein: Bub3 interacting GLEBS and zinc finger domain protein, isoform E (M9PG25)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRKKKKASKPWYCNREFDDEKILVQHQKAKHFKCHICHKKLYTGPGLSIHCMQVHKETVDKVPNSLPNRSNIEVEIFGMDGIPAEDLRDHERQKNGGKSDSDDDEPVAKKKVEYAMSVPPPMMMPPNMMPPHMLGQYGMGMMQHMPPLPPYPVPMMPHMMPPRPLFPAAMATTSAAAAAAAAHHHHAAAMAQQKPTFPAYSNATISAPPTTNHAGGASSAPPSGPPDAQQHQQRPPAPPAASGTSAAAVTTKIMHPQEDLSLEELRARQPKIQARLAAALASLANPQSRKSPSNNGGPSTSIPTTPPPPSLAGISPTGSNSSSGMANSIVVSAAMSKAQENAALVAVAQAQAHAHAHAAQVQAQAQAQAVVQAQVQAAHVAHAVAAQQQAVQQQQAAQQQQQAAVQQQAAVQQQQQQQQAAVQQQQAAQQQVKQLEELNRAVMLQRFQAARQPGNPGAAAAAAAAAAVGMMPLPGHMQLMQPMLRPAMAIGPHGTLIGGNMLRAGGPGLHGMPADIHYDCGLGLLPMQIGLPGMPGALPAGAMAMPGMGVMLQGHPNMLQMMQPRFR