wanglab/gogpt-training-data huggingface dataset:
Protein: Elongator complex protein 3 (EC 2.3.1.311) (Gamma-toxin target 3) (tRNA uridine(34) acetyltransferase) (Q02908)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). The complex functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitivity to Pichia inositovora toxin. Independently, ELP3 may be involved in polarized exocytosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15780940}. Nucleus {ECO:0000269|PubMed:10024884}.
Interaction partners:
- Elongator complex protein 4
- Elongator complex protein 2
- Elongator complex protein 6
- Elongator complex protein 5
- Elongator complex protein 1
- Protein KTI12
- Diphthamide biosynthesis protein 3
- Cytoplasmic tRNA 2-thiolation protein 1
- Cytoplasmic tRNA 2-thiolation protein 2
- Histone acetyltransferase GCN5
Sequence:
MARHGKGPKTNKKKLAPEKERFIQCCADITLELTDSLTSGTTREINLNGLITKYSKKYKLKQQPRLTDIINSIPDQYKKYLLPKLKAKPVRTASGIAVVAVMCKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYEQARGRVEQLKQLGHSIDKVEYVLMGGTFMSLPKEYREDFIVKLHNALSGFNGNDIDEAILYSQQSLTKCVGITIETRPDYCTQTHLDDMLKYGCTRLEIGVQSLYEDVARDTNRGHTVRSVCETFAVSKDAGYKVVSHMMPDLPNVGMERDIEQFKEYFENPDFRTDGLKIYPTLVIRGTGLYELWKTGRYKSYSANALVDLVARILALVPPWTRIYRVQRDIPMPLVTSGVDNGNLRELALARMKDLGTTCRDVRTREVGIQEVHHKVQPDQVELIRRDYYANGGWETFLSYEDPKKDILIGLLRLRKASKKYTYRKEFTSQRTSIVRELHVYGSVVPLHSRDPRKFQHQGFGTLLMEEAERIAKEEHGSEKISVISGVGVRNYYGKLGYELDGPYMSKRI
Protein: E3 ubiquitin-protein ligase pellino homolog 1b (Pellino E3 ubiquitin protein ligase 1b) (Zgc:153297 protein) (A4QN36)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Interleukin-1 receptor-associated kinase 1
- Interleukin-1 receptor-associated kinase 4.
- TNF receptor-associated factor 6
- Receptor
- Receptor-interacting serine-threonine kinase 3.
- Ubiquitin-conjugating enzyme E2 variant 1.
- Ube2n protein
Sequence:
MFSPDQENISTSSTKVPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKSNGVKPSTVHVACTPQAAKAISNKDQHSISYTLSRVQTVVVEYTQDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIMCQRTPPYNARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRHGFTEDSKPGVWREISVCGNVFTLRETRSAQQRGKMVENETQELVDGSLIDLCGATLLWRTAEGLSRTPTIKHLEALRQELNAARPQCPVGFNTLAFPSMRRKDIVDEKQPWVYLNCGHVHGYHNWGNRDAERDGREGRERECPMCRARGPYVPLWLGCEAGFYLDAAPPTHAFSPCGHVCSEKTAAYWSQIPLPHGTHTFHAACPFCAQQLNGEQGYIRLIFQGPVD
Protein: Protocadherin beta-6 (PCDH-beta-6) (Q9Y5E3)
Organism: Homo sapiens (Human)
Function: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q91XZ4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q91XZ4}.
Interaction partners:
- Protocadherin beta-16
Sequence:
MMQTKVQNKKRQVAFFILLMLWGEVGSESIQYSVLEETESGTFVANLTKDLGLRVGELASRGARVVFKGNRQHLQFDPQTHDLLLNEKLDREELCGSTEPCVLPFQVLLENPLQFFQASLRVRDINDHAPEFPAREMLLKISEITMPGKIFPLKMAHDLDTGSNGLQRYTISSNPHFHVLTRNRSEGRKFPELVLDKPLDREEQPQLRLTLIALDGGSPPRSGTSEIQIQVLDINDNVPEFAQELYEAQVPENNPLGSLVITVSARDLDAGSFGKVSYALFQVDDVNQPFEINAITGEIRLRKALDFEEIQSYDVDVEATDGGGLSGKCSLVVRVLDVNDNAPELTMSFFISLIPENLPEITVAVFSVSDADSGHNQQVICSIENNLPFLLRPSVENFYTLVTEGALDRESRAEYNITITVTDLGTPRLKTQQSITVQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGINAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQSFEFRVGATDRGSPALSSEALVRLLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRYSVPEGPFPGHLVDVSGTGTLSQSYQYKVCLTGGSETNEFKFLKPIMPNFPPQGTEREMEETPTSRNSFPFS
Protein: Rho guanine nucleotide exchange factor (GEF) 28a (Rho guanine nucleotide exchange factor 28 isoform X2) (F6P6M2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Rho-related GTP-binding protein RhoA-C
Sequence:
MELSRGEVPLYGQVEVCVKLPLSEFVQEETDYYVLLVGSSLHHVTAAHRTEDHSSIRFTVPGHIVPEKVSVEVYSCTKESKSPISPFCHSEKLSVEYILDEVQEVAEQLMNFETLTSSSHQDILKKLYPKKKVFSEKNHVEQTAQHGTDGVCDPHGGLLQLESLAETEQGFNVCEQGNLSQSEVSGTEEFDPEQHSSVDEKVTQALANLHFLGWDGQAGQENQVLLPRETPLHVAMRLGFPHLSHFLLREFNGQMMVSIANEEGHTPVALAEKHGDPVLITALTHGSALRPVWMCQIWTDCSQQLRICPVTDSISLTVRHQTLINVQNSIQLYREKSKEPDILTRVRHLSELSEGSVHRSDECDADLNNSLKIEDQTLVDSVFEEQLVLCLDEEDEDLSVFNSEKQFSSPGSCTPFHLHSSAAAAVRLTAMLKGSTKDSELNMKYAVPGATEDSSGTDSGMWRMSDTGVSSPGTIDISPTVKDDEGQRGRYPASRSFSPTSPAGLMLDRFMRATRTTELTYNSSSSPTESCDLRSPILSLSPSLVALEMDSEEDDDDDILMKKPLPQLQPDSKDSTDEQVMSSPAPVLICTRSHSASSACNPAPAKDVEQGVRLRSYSYTSPKISLLPPRFSRDAHPPPADLSQEHRSSSTSEQPQEKRIEEEEWDKYIIPSKTESEKYKVSRTFSFIKSRMYSTRNKNKGKGKEKETKDKQVNGHQFTAGSVLGSTLCEICSKPASGKEVVHCTHCAVSVHKGCKDSSTPCLKKPQDKYSVMTVKSKTASLPQNFIVRESSSSSLQISTSASLPVMTSRDSAPLPCPLSRSVPLTTERLSESPEADSDSNLWRNHIQSEELLQTMESSTSTDSSIIEDSVDSPLQIELLMNAVDLEAESWSLAVEAQFCRMQEKRIIKRQDVIYEFMQTELHHVQTLMVMAEVFRRGMRDEVGLDAETIGRIFPCLDELLQLHRDFLTAMRERRQSCVQNNSSKNFLIHRVGDIFLQQFSQENAEKMKQVYGEFCSHHTEAVSYFKELQQQNKRFQLFIKQQSSNSLVKRREIPECILLVTQRITKYPVLLERILQYTDEGTEEHSDLSRALVLIRELISAVDQYVSQYEQNQKLSEVLGRMENKCSTKLKTGCTFRKQDITSGRNLLHQGPLLWKTATGRLKDVLAFLLSDSLVFLQEKDQKYIFATVDQKPPVISLQKLIVREVANEERGMFLISASSAGPEMYEVHAASKDERNAWMRLIREAVENCPEEEDETTSESEEERRVTEAKVQKIHRLQETLCGHDHLICSNLEEKLHIYAELSVMAGQREAGPEPRLLVRPSTEDVPQAGVLLSAALREAESLRAALSSHCASTPPVPSGPEDLNKPEPCTPPSPLPPESPLTDPIQSEEEEWRTEESSEAQTFNHNSDSDHNLQLKVSQSVQSLTQLLYSLQAAVTIQDSCYEVQKLLLLLMSSPAPNQQSRPLSITRSGQALHEQERQREAERRREELADVARLRGALVRERQQWERECQARQLQHSELETTLEQRELLCHLEERRLQSERQELQEQLQEYQQSLERLREGQRNVEKEKEKLETQKMLLEGLKHGCQQNLPAMVIPLDGQQTQNHLGIQDEHGSIFVNEAAFISSSVNNRHLHLQHHPQHHHQTVHVHSGSIGYSDSPSAQNSLNSLLARSNHRPSSAGASDHSWTSLRSLTESANNNVGQISHVEESWSAGVTGAGLHQTDVLLVSQPFLSMETENRDTDGEETIVYL
Protein: Collagen type VI alpha 2 chain (A0A8I5Y5R7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTTTTKMLQGSFSVLLLGGLLGVLHAQQQEAISPDISTTDRNNNCPEKADCPVNVYFVLDTSESVAMQSPTDSLLYHMQQFVPQFISQLQNEFYLEQVALSWRYGGLHFSDQVEVFSPPGSDRASFTKSLQGIRSFRRGTFTDCALANMTQQIRQHVGRGVVNFAVVITDGHVTGNPCGGIKMQAERAREEGIRLFAVAPNRNLNEQGLRDIANTPHELYRNNYATMRPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPGPHGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGSDGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGSRGPDGYPGEAGSPGEQGDQGAKGDSGRPGRRGPPGNPGDKGSKGYRGNSGAPGSPGVKGGKGGPGPRGPKGEPGRRGDPGTKGGPGSDGPKGEKGDPGPEGPRGLAGEIGSKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGTPGEKGEPGPPGPEGGRGDFGLKGAPGRKGEKGEPADPGPPGEPGPRGPRGIPGPEGEPGPPGDPGLTECDVMTYVRETCGCCDCEKRCGALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIRLDDERVNSLSSFKEAVKNLEWIAGGTWTPSALKFAYNQLIKESRRQKTRVFAVVITDGRHDPRDDDLNLRALCDRDVTVTAIGIGDMFHETHESENLYSIACDKPQQVRNMTLFSDLVAEKFIDDMEDVLCPDPQIVCPELPCQTDEPWPGNKPPVTFLRTEEGPDPTFPKTIPLIQQLLNATEFTQNPAAYSQLVAVMVYTAERAKFSTGVERQDWMQLFIDTFKLVHRDITGDPESVLALC
Protein: DNA repair protein RAD51 (P25454)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required both for recombination and for the repair of DNA damage caused by X-rays. Its function may be modulated by interaction with other repair proteins. RAD52 interacts directly with RAD51, via its C-terminus. Forms a nucleoprotein filament with DNA as an early intermediate in recombination.
Subcellular location: Nucleus {ECO:0000269|PubMed:16818607}. Chromosome {ECO:0000269|PubMed:16818607}. Note=Localizes as foci on meiotic chromosomes.
Interaction partners:
- DNA repair protein RAD55
- DNA repair and recombination protein RAD52
- DNA repair and recombination protein RDH54
- ATP-dependent DNA helicase SRS2
- DNA repair protein RAD59
- ATP-dependent helicase SGS1
- DNA repair and recombination protein RAD54
- Replication factor A protein 1
- Exodeoxyribonuclease 1
- DNA repair protein RAD57
Sequence:
MSQVQEQHISESQLQYGNGSLMSTVPADLSQSVVDGNGNGSSEDIEATNGSGDGGGLQEQAEAQGEMEDEAYDEAALGSFVPIEKLQVNGITMADVKKLRESGLHTAEAVAYAPRKDLLEIKGISEAKADKLLNEAARLVPMGFVTAADFHMRRSELICLTTGSKNLDTLLGGGVETGSITELFGEFRTGKSQLCHTLAVTCQIPLDIGGGEGKCLYIDTEGTFRPVRLVSIAQRFGLDPDDALNNVAYARAYNADHQLRLLDAAAQMMSESRFSLIVVDSVMALYRTDFSGRGELSARQMHLAKFMRALQRLADQFGVAVVVTNQVVAQVDGGMAFNPDPKKPIGGNIMAHSSTTRLGFKKGKGCQRLCKVVDSPCLPEAECVFAIYEDGVGDPREEDE
Protein: Uncharacterized protein (Q57WL1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTAVKEPRVDFELHNSSIARDDACLQWLFSRYRAHTSTTLPSRSDTSAAPTTKGNDNIKNATEALLVQLENDVTACKALRWEKFRYSSPIYEAASPTYPLRRGSTIETVVEEVEDSAATTGTVGKPHRVLRVKLQESSPKHDHEARVRSVQEEPSRHVFAEMLRKKNRENLVRSIEEAEAARGHNGHSGWLRPYFGGYFHMPLPRGPTRFLVFPQWHHDVTVATEKQQWFPYFLRGSCYQKVPHARVPIVGDAVGPLRMPWNDLVLAVSFAREFPRELSEDFGDRVRLWRDVDAIYLDGHANQVRTERLVLCKTRSKSPEMSHLSAGETAVVGMTEEAEAEGKETETEIITTKLRESGFRASLQFRNPRYSLTVKGTTCIPERAPNQRITSLLVLDEYDSFVQHFTSPFLRWLFPRATYCLRWAGGPGVDFNSDERSLTFFGKLWSEWWVELPLRADRFFLRLRNKSSLVQPLTAGQWKQTFSDVQVNGSHGNHAVRSGEHSLFWATQGPVWDAGLIRGFRDIYPGMHYASRWYTVLSMELGFGGKLRDESKMLVDGASQTGWRKPGGMIYANACLMDSFKNPPRASMGFSLTSGPRAKEDAFNTLAPSSFECNFNWWLKFGRDGMKLLSGLVEGQSVDKAVLRPSATEAFHHLRCGLTWNL
Protein: At1g05410/T25N20_5 (CDPK adapter, putative (DUF1423)) (Q8VZE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- AT5G14540 protein)
- At5g08360
- At1g73210
- At3g50040
- At3g26990
- Uncharacterized protein At4g21930
- Elongation factor
- At1g44770
- Uncharacterized protein
- At5g09670
Sequence:
MDSMDIDQSNIGESPHLLLRPVSPLESGEGLPYAPENWPNPGDTWHWKVGPRISGKGYFVDRYLYPPKYLPGLDTEILRKNKVFRSRLSLQRYIRVHFPEADVQKFFASFSWSIPCRDGQGVLPQKQVQLPVYSSDEDPMRDDGSDTAVCKAGNEKCRSLMPQCEAETLPAMPCDICCGERKFCVDCCCILCCKLISLEHGGYSYIKCEAVVSEGHICGHVAHMNCALRAYLAGTIGGSMGLDTEYYCRRCDAKKDLFPHVNKFLEICQTVEYQGDVEKILNLGICILRGAQRDNAKELLNCIESTVIKLKCGTSLEDLWNDDTPTIWSDYSDSGEARENDTLQSLQDVTPIGPIPFNHEAEMHKLEEEIGEVLRALRKAQEFEYQIAEGKLHAQKECLSDLYRQLEKEKSELSRRVSGTDANSLMTNVLKRLDQIRKEVTKLKEMEEVAKGFGRTPRGVLEEYFHLNIED
Protein: Ion_trans_2 domain-containing protein (H9G2R7)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDDIYEEYFDNDDIARTDSEAEGTVYKNSYASLMNELQPTTSFDDFKQSITQLTDIFRADPARMQYGEKKNIKHKLQQWFIENPSISARIRSCNVLIKLLTCILYCIRVVNDERSYPDDFPFSEEEAGKQDVTLYKYLLWVDFDFKIWFLQTMFACISMVYTILVFYLSYSGSVVRLLINIHFLLELITSFPFIISIFIPSLTYLYVPVFLNCWLAKGALQAMMNDLNRKSFISSSALFRQLLLLFSVLACLIFTGMCSIEHLQRARGKRIDLFTSFYFVMVTFSTVGYGDWYPDYWASQLCVVILICVALGLIPKQLDELGQTWSERQKSGTDFSSWNGVESHVVVTITTLEVEFIRDFLEEFYAHPENQRIQIVLLSPAELDNQTRMLLKIPLWNNRVHYVRGSSLRDEDLERANVATSKACFILSARHVNRKVATDEHTILRSWAIKDFAPNVKQYVQIFRAETKMHIEHAEVLICEDEFKYALLANNCICPGISTFITLLMHTSRGEEGQKSTEPWHKVYGFHSGNEMYQIKVQDSKFFCEYVGKSFSSTSFHAHKEYGIGLIAVSPDGDTSRMKLNPGSSHIIQPTDTVYYMGLTNEESLTDFRKGIRSQQKRANVASTIANIGTVAVDVPRSDKTELVGRKKKKRKEKAADEIHLIEVGEHVQSSRRPSIAMVTEGKIDSSSDSDQEEICDKCRGPCIQHKLQRTYPQVRTYIGTSNTVCHMMKERRSLCCLKLDEKCAHKSATSAHEYQWRNRPIILAADRTSSGMYNLVIPLRAYYRPVHDLHPIIILLELEEQDSLNDAFLDAISYFPDVYWMKGKVGNLDCLLRAGVSSAEHVVVVKETAVMAEEHTADCNTIITVQKIHRMFPRLRMITELTHATNMRFVQFNPHNAYSLAQSRFEKKERKRGSHMPFMFRLPFAQGGVFSANMLDRLLYQAIIKPFVVDLVRLLLGIDQHSDGGYLTSFVITSDDLWIRNYGRLYQKLCSSVADIPIGIFRTKKMDTKTVSLDLQEQCKDFENTEMGRNKDMYDHVKNRMRLLNIKDTHTLLEGSDEKSQISYVIINPAQDLELESGDIVYVIRSPIRKDATNARINPRRGLRRSKNVSETIDSTNQVPTIVIDENNL
Protein: Virus-induced RNA 1, isoform G (M9PFQ2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKLLFGLLMTVLALSGVFTLPARNDPQDDAEVIKVPSRPQPESDFHNFRGVIDTGSGYPFLQPNPSSFNVGIFDSFDDLFRRLRTRLWPVIGRDSGEEGASPTGDSDDSSDGSGAGFPFGVRPLIPLDSKNANTTSTIKVVNGHKVEINETVYGDSNSVFKVRLVNVRPLESGEEVAQGVHTSGGDFQPALEPSTSAPPKKFEEFDEEDDDDRREPLEKQPQDNESTTPTNTSYTTNLHTSAPIDSEFEASDISEDIVETQPEEQKNTMDQLQQMMEPLREEIRHEEDLEQEHEDKEYLERKEKKEREEFDSSDDEDGEATTPVVMSETFNDEWAEFDQDQDREHDRNEDQDHDLDFENDLNNEIDIEENFVPIDLSNDIAVNDLAAADPNFPINEDAEFIVHPAVIRTMPMFEKLSLGEPAK
Protein: NKG2-E type II integral membrane protein (NK cell receptor E) (NKG2-E-activating NK receptor) (Q07444)
Organism: Homo sapiens (Human)
Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- HLA class I histocompatibility antigen, alpha chain E
- Natural killer cells antigen CD94
- TYRO protein tyrosine kinase-binding protein
- NKG2-C type II integral membrane protein
- Killer cell immunoglobulin-like receptor 2DL1
- Killer cell immunoglobulin-like receptor 2DL3
- Killer cell immunoglobulin-like receptor 3DL1
- Killer cell immunoglobulin-like receptor 3DL2
- Killer cell immunoglobulin-like receptor 3DL3
- NKG2-A/NKG2-B type II integral membrane protein
Sequence:
MSKQRGTFSEVSLAQDPKWQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNARTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLQACASKNSSSLLCIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHEIKDSDHAERNCAMLHVRGLISDQCGSSRIIRRGFIMLTRLVLNS
Protein: 4'-phosphopantetheinyl transferase PptT (PPTase) (EC 2.7.8.7) (O33336)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. Involved in post-translational modification of various type-I polyketide synthases required for the formation of both mycolic acids and lipid virulence factors. Acts on Pks13, Mas, PpsA, PpsB, PpsC and PpsD. Also acts on AcpM, the meromycolate extension acyl carrier protein. In addition, is involved in the activation of the acyl carrier protein MbtL and the nonribosomal peptides synthases MbtB and MbtE, which are involved in the biosynthesis of the siderophore mycobactin.
Interaction partners:
- [Acyl-carrier-protein] phosphodiesterase PptH
- Phenyloxazoline synthase MbtB
- Polyketide synthase Pks13
- tRNA pseudouridine synthase B
- Salicyl-AMP ligase / salicyl-S-ArCP synthetase
- Peptide synthetase MbtE
- propanoyl-CoA C-acyltransferase
- Probable acyl-CoA dehydrogenase FadE21
Sequence:
MTVGTLVASVLPATVFEDLAYAELYSDPPGLTPLPEEAPLIARSVAKRRNEFITVRHCARIALDQLGVPPAPILKGDKGEPCWPDGMVGSLTHCAGYRGAVVGRRDAVRSVGIDAEPHDVLPNGVLDAISLPAERADMPRTMPAALHWDRILFCAKEATYKAWFPLTKRWLGFEDAHITFETDSTGWTGRFVSRILIDGSTLSGPPLTTLRGRWSVERGLVLTAIVL
Protein: Defensin-like protein 32 (Q2V4I8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Defensin-like protein 35
- Transmembrane protein
- Defensin-like protein 10
- Defensin-like protein 6
Sequence:
MVSSRKCVFLVFLCMVVLLNPKSTKAKDIDGRKPLLIGTCIEFPTEKCNKTCIESNFAGGKCVHIGQSLDFVCVCFPKYYI
Protein: LD42289p (Q8MR16)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
LLPNFRMNTIRPCGCKGVRTCLSCEQDFHIAKTSLREQFQQLEAWSYCIQCDLLQRGWDTNHVQKDHENHKKDEGLPLPGILVQEEFLSVDEGAQLIADLDDLPWDISQSGRRKQNFGPKTNFKKRKLRLGSFAGFPRTTEYVQRRFEDVPLLRGFQTIEQCSLEYEPSKGASIDPHVDDCWIWGERVVTVNCLGDSVLTLTPYEVQQSGKYNLDLVASYEDELLAPLLTDDQLATFEGKVLRIPMPNLSLIVLYGPARYQFEHSVLREDVQERRVCVAYREFTPMYINGVDIQKGDPVREKSQIFWQIN
Protein: Tyrosine-protein kinase receptor (EC 2.7.10.1) (Q1LVG4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Insulin
- Insulin
- Insulin receptor substrate 2a.
- Insulin receptor substrate 2
- Insulin receptor substrate 1
- Insulin receptor substrate 2-B
- Protein tyrosine phosphatase non-receptor type 1.
- SHC-transforming protein 1
- SHC adaptor protein 3.
- Growth factor receptor-bound protein 10 isoform X2
Sequence:
MRLDTSVVVLVTFAYILCLCGSLHGEICPSTDIRNIATNLRVLENCTVIEGHLKILLMFKTTQEDFRGLSFPKLVMVTDYLLIFRVYGLESLGSLFPNLTVIRGSNLFFNYALVMFEMIQMKEIGLHSLTNITRGAVRIEKNPNLCYLSTLDWSKILDSVEDNYIVANKDDLECGNICPGTIAGTISCKQTTINGNFGERCWNQNHCQRICPSECVHGACTSHKECCHEQCLGGCSVPGNSTKCVACRNFLYGEACVDRCPPGYYTFKSWRCVSLQFCQDLHNQCKDKSGDCHAYVIHNGACIPECPSGYTTVNSTSLTCMPCTGRCPKVCTGVQTVDSVTAAQALRGCTVLNGSLIIKISGGNSIAAELESSLGQLEEITGYLTIRRAYALVSLSFLRKLHLIRGETLDGGNYSFHAMDNQNLRQLWDWNKHNLTILKGRMKFIQNGKLCKSEILRMEQATGTKNRMNDISNEKDQSYCESHILKFTQIRTMSDKILIRWESFWPSDFRDLLGFMVLYKEAPHRNVTEYDGQDACGSNSWAIADVEPPQRPSEGKEVEPGYLIMPLKPWTQYAVMVKAQLAASEDHQVRGAKTEIIYVRTNATRPSVPLDPHSWSNSSSQIILKWKPPSDPNGNITHYIIYCQKQSEDITHYKFDYCQQGMKVPSHTPTHHDVEEDQKLNQTEVPDQKGHCCACPKTEMQLKKEAEETEFRKTFENYLHNEVFEPRPHRRRRSVGVANATLPNFGTTPTIIPNFPTTSIPEEEKSRKMVFKASSKEAMVISNLLHFTSYQIEIHACNDPTDPGRCSMPTYVKARTLPELKADVIAEPVTHEFFPDEPDVVYIRWKEPKTPNGMIILYEVKYLRMSDNYEDQICVSRISYEKNHGYRLRVGHPGNYSVRVRATSLAGNGSWTDPAYFYVQDREMSMKIVIILAICIFLLVILASVGYFVLKKKQTEGPTGPLIASSNPEYISANDVYIPDEWEVPREKITVMRELGQGSFGMVYEGIAKDIIKGEPDTRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSKGQPTLVVMELMTHGDLKSYLRSLRPDAENNPGSPPPTLKEMIQMSAEIADGMAYLNAKKFVHRDLAARNCMVAEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGYLDRPENCPERMHNLMQMCWQYNPKMRPTFHEIIEMIKEDLHPTFQEVSFFYSEENKAPESEEFDMDFENMESIPLDPSSYSQREESHSRDNGPSVGLRGNYEEHVPYTHMNGGKKNGRILSLPRSSPS
Protein: Matrix protein 2 (Proton channel protein M2) (P06821)
Organism: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Function: Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
Subcellular location: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04069}. Host apical cell membrane {ECO:0000255|HAMAP-Rule:MF_04069}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04069}. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion). {ECO:0000255|HAMAP-Rule:MF_04069}.
Interaction partners:
Sequence:
MSLLTEVETPIRNEWGCRCNGSSDPLAIAANIIGILHLILWILDRLFFKCIYRRFKYGLKGGPSTEGVPKSMREEYRKEQQSAVDADDGHFVSIELE
Protein: Phospholamban (PLB) (P61015)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P26678}; Single-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P26678}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:A4IFH6}; Single-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:P61014}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with HAX1 at the endoplasmic reticulum. Colocalizes with DMPK at the sarcoplasmic reticulum. {ECO:0000250|UniProtKB:P26678}.
Interaction partners:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- cAMP-dependent protein kinase
- Calcium-transporting ATPase
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
- cGMP-dependent protein kinase 1
- Sarcolipin
- cGMP-dependent protein kinase
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Serine/threonine-protein phosphatase
Sequence:
MEKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLILICLLLICIIVMLL
Protein: Immediate early response gene 2 protein (Q6P7D3)
Organism: Rattus norvegicus (Rat)
Function: DNA-binding protein that seems to act as a transcription factor (By similarity). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells. May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BTL4}. Nucleus {ECO:0000250|UniProtKB:Q9BTL4}. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation. {ECO:0000250|UniProtKB:Q9BTL4}.
Interaction partners:
Sequence:
MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSARELYLSAKVETHQPEFPPSRRALDPRLHPPREPEAAMEAATPDVEQPPEPMDTQEEVLRVQETPALCDPPPARVSRKRRSSSDLSDGSDAGLVPSKKARLEEVEGEATSEVSNRLQLPPAQTEGAFPNLARVLQRRFSSLLNCGPAVPPPTPPTCEAKPACRPADNMLNVLVRTVVAF
Protein: Ribonuclease M5 (EC 3.1.26.8) (RNase M5) (Ribosomal RNA terminal maturase M5) (P37547)
Organism: Bacillus subtilis (strain 168)
Function: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. Releases 5'-phosphoryl and 3'-hydroxy termini.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01469, ECO:0000269|PubMed:11233981, ECO:0000269|PubMed:402365}. Note=Associated with 70S ribosomes.
Interaction partners:
- Ribosomal RNA small subunit methyltransferase A
- Mini-ribonuclease 3
- Ribonuclease J1
- Ribonuclease Y
- Ribonuclease Z
- 3'-5' exoribonuclease YhaM
- Ribonuclease 3
- Ribonuclease HIII
- Putative cell wall shaping protein YabE
- Uncharacterized metal-dependent hydrolase YabD
Sequence:
MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRLAQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVESIRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQKRLQMFQIKKSDFMSALDTVMREEQNE
Protein: Homeobox protein TOS8 (Target of SBF 8) (P53147)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGTSIVNLNQKIELPPIQVLFESLNRENETKPHFEERRLYQPNPSFVPRTNIAVGSPVNPVPVSSPVFFIGPSPQRSIQNHNAIMTQNIRQYPVIYNNNREVISTGERNYIITVGGPPVTSSQPEYEHISTPNFYQEQRLAQPHPVNESMMIGGYTNPQPISISRGKMLSGNISTNSVRGSNNGYSAKEKKHKAHGKRSNLPKATVSILNKWLHEHVNNPYPTVQEKRELLAKTGLTKLQISNWFINARRRKIFSGQNDANNFRRKFSSSTNLAKF
Protein: (-)-5-epieremophilene synthase STPS3 (EC 4.2.3.199) (Sesquiterpene synthase 3) (SmSTPS3) (A0A1W6GW18)
Organism: Salvia miltiorrhiza (Chinese sage)
Function: Sesquiterpene synthase that catalyzes the conversion of farnesyl diphosphate to (-)-5-epi-eremophilene.
Interaction partners:
Sequence:
MATTQVEIQRPIANFSPSLWGDQFIKNDSGAKAAEKHCKAVEELKKEVMNMITAAESNLVEAMNLIDTLERLGISYHFEKEIDQKLNHFFSLNTDYSDESYDLYTVSLHFRLFRQHGHRISSDIFGRWIDESGKFKEGLKTDGKGLLSLYEASYLRTRGETILDDALEFATATLNSIAPHLESPLSKQVVHALIQPLHYGNPRIEAHNFISIYEENQDKNEFLLKFAKLDYNLLQMLHKEELHEVSRWWKELDLVSKLPYARDRVVECFFWAMGVYHEPQYSRARIMLTKTITMTSIIDDTYDAYGVIEELDIFTEAIERWNIEEMDRLPEYVKPFYKALLELYEQFEEELAEEGRSYAAHYAIESLKELVRSYHVEAKWFIQGYLPPFEEYLKNALITCTYCYHTTTSLLGVESAVEEDFQWLAKKPKMLVAGLLICRVIDDIATYEVEKERGQSATGIESYMRDNNATIEEAVAKFFEIATDAWKDINEECLMPSPYSRDVLMRILNLERIIDVTYKGNEDGYTQPEKVLKPHIIALFVDPIKM