wanglab/gogpt-training-data huggingface dataset:
Protein: Leucine-rich repeat-containing protein SOG2 (Q08817)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for proper cell morphogenesis and cell separation after mitosis. Functions in the RAM (regulation of ACE2 activity and cellular morphogenesis) signaling network and is required for proper ACE2 localization and CBK1 kinase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12972564, ECO:0000269|PubMed:14562095}. Note=Localizes to cortical sites of growth during both budding and mating pheromone response. Localized prominently to incipient bud sites and small buds and weakly to the cortex and bud necks of large budded cells. Also localized to the growing tips of mating projections.
Interaction partners:
- Serine/threonine-protein kinase KIC1
- Protein HYM1
- Serine/threonine-protein kinase CBK1
- Cell morphogenesis protein PAG1
- CBK1 kinase activator protein MOB2
- Elongin-C
- Metallothionein expression activator
- Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease
- Dynein heavy chain, cytoplasmic
- U2 small nuclear ribonucleoprotein B''
Sequence:
MVATSSKRTLDPKEEHLPADKTSTNSSNTIISELATQEKSSSSGTTLKLIALNIKSISDEDVGYIQNVERLSLRKNHLTSLPASFKRLSRLQYLDLHNNNFKEIPYILTQCPQLEILDLSSNEIEALPDEISSFWQDNIRVLSLKDNNVTSIRNLKSITKLNKLSILDLEDNKIPKEELDQVQSYTPFHTGIPKEEYWAIAISRYLKDHPNLPTPEPKISRAAKRMGFINTNLSNGAMNENNIISLAPSANTTISASTAMVSSNQTSATSFSGTVNAESEQSGAVNGTELYNHTKYNDYFKRLSILPEESMSNGHQKISHAELVVSCRKLLFSFTECQQAIRKIASFCKEKAVAVNVVSLLYSVRSHTDNLVEVLQQTENEDESHDQALIKLCLTIITNFKQIITLLRKNFEIFFKEDDLCFIRMFYMTLMCAYMEMYNAWSFIKEDDQVSGSASKAPKKHSFSRHETSSSSITSGGGPAASTTSTHCSGNIKLLPKTRSTRTPSASALLSNSNILTGDTTAVPLLSPNLNGAHTHGPILGHQNAISNGSSQTNMNEVKTTSDTIPRQQLLQHNKSISDSKKESQAHEPKQHPVMTSSIINASNSNNVSNVNITPPPMNGGGAANSSANVVETNIDIQLYQTLSTVVKMVSVVYNQLTSEISKIAIASTMGKQILTDSLAPKIRDLTETCRQAMDLSKQLNERLNVLIPNDSNSEKYLTSLEKLKTWEIMNSFLKVIISILANTKIVMSDVPNLNELRPNLANLAKITKDVTVILDLSSYKAVSVSANSPE
Protein: Arsenical resistance operon repressor (P37309)
Organism: Escherichia coli (strain K12)
Function: Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity).
Interaction partners:
- Arsenical pump membrane protein
- Arsenate reductase
- Nickel-responsive regulator
- Transcriptional activator CadC
- HTH-type transcriptional regulator ZntR
- Zinc/cadmium/lead-transporting P-type ATPase
- Transcriptional repressor RcnR
- Multiple antibiotic resistance protein MarR
- HTH-type transcriptional regulator GntR
- Regulatory protein AsnC
Sequence:
MSFLLPIQLFKILADETRLGIVLLLSELGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWAAKIIDEAWRCEQEKVQAIVRNLARQNCSGDSKNICS
Protein: G protein-regulated inducer of neurite outgrowth 1 (GRIN1) (Q3UNH4)
Organism: Mus musculus (Mouse)
Function: May be involved in neurite outgrowth.
Subcellular location: Cell membrane; Lipid-anchor. Cell projection, growth cone {ECO:0000250}. Note=Highly enriched in growth cone.
Interaction partners:
- Methyl-CpG-binding protein 2
Sequence:
MRDCCSSPKAIPAPPRHALDQSLGMDPRHTSSSGAAEGASCSERPAGSLACPSPNCSPLPETPRAHGALTSDNSGTTLFGKPEPMSSAEATPTASEIRNPVFSGKMDGNSLKQADSTSTRKEEAGSLRNEESMLKGKAEPMIYGKGEPGTVGRVDCTASGAENSGSLGKVDMPCSSKVDIVSPGGDNAGSLRKVETISSGKMDPKTENVMHSRRERPGSTGEGDLVSLRENDMKPPDNTDSASTKKTDPEFSGKLTPGSSGKTELVSSVTVAPVTSENVNPVCSGGAGPAAVGNSETLSSVKKDPQLLGKKEAVSSGEGGSVSVRMAETVSARQPEGMFPAKTDSTSSNSTGPSGRADPVSLRNSELVSPVKPERLSSGQAERVSLVKTETLSSGKEDPRSSRRVDHTTVTGNMQTSQKGNPESSGKTDLGSSSSGDTRSLGTWGSLSAAKAEVTEGKGDPQPWKKASLPASEKTDPLASSKAGSASQGKAETVSPGEVDAMTLGKTVPTSSGKTALVSPGKVDLMTSERAEGIPELQASEKGNPVNSTRVDTGATGSTEPKSGVKVITQIPGATSPGKVETPSLQKEQPQLSEKTDPSRKVDPPTTVEPVSLGKADSASPSPRKAESQTSAKTVPQAPDKATSSLRQSDGTPYSSAQPQRDTRSIGSLPEREPSASTSQKDLAAAAAQKSPSAEAAAPPPGPRTRDNFTKAPSWDAGAPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGPAFSFQAAPRAPSPAPRPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAVPPVFPEVRVRPGSVLAAALAPQEATEPVRDVSWDEKGMTWEVYGASMEVEVLGMAIQKHLERQIEEHGRQGAPAPAPPPAVRAGPGRAGSVRTAPAEGAAKRPPGLFRALLQSVRRPRCCSRAGPTAE
Protein: Sodium/potassium-transporting ATPase subunit alpha (E1B8N5)
Organism: Bos taurus (Bovine)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362084}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit beta
- Protein ATP1B4
- Sodium/potassium-transporting ATPase subunit gamma
- Sodium/potassium-transporting ATPase subunit beta-2
- Sodium/potassium-transporting ATPase subunit beta-3
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase 1
- cGMP-dependent protein kinase 1
Sequence:
NLFIGGRVLFLFKLYFSRAQEILTRDGPNALTPPSTTPEWVKFCKQLFGGFSLLLWTGAILCFVAFGIQLYFNEDTTKDNLYLGIVLTVVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKFQIPVYEVVVGDLVEVKGGDRIPADIRLISSQGCKVDNSSLTGESEPQSRSTEFTNENPLETQNICFFSTNCVEGSAQGIVIATGDSTVMGRIASLTSGLAVGKTPIAIELEHFIHLITGVAVFLGVTFFGLSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWFDKTIYEADTTEEQTGNPFAKGSDTWFILARIAGLCNRADFKANEESLPIAKRATTGDASESALLKFIEQSYSSVNEMREKSPKVAEIPFNSTNKYQVSIHLREDSSQAHVLMMKGAPERILEFCSTYLLKGQEYPIDDEMKDAFQNAYLDLGGLGERVLGFCFLNLPNTYPKGFKFNTDEINFPINNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGSETAEDIAARLKIPVSKVNPRDAQAIVVHGSELKNMNSEQLDEILQNHTEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGIAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRAPRNSKTDKLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFKPPDLLGIRVNWENRYINDLEDSYGQQWTYEQRKVLEFTCQTAFFVSIVIVQWADLIICKTRRNSIFQQGMKNKILIFGILEETILAAFLSYTPGMDVALRMYPLKITWWFCATPYSLLIFVYDEIRRLIIRRYPGGEAPPHLGLRGR
Protein: Gamma-secretase subunit APH-1 (APH-1) (Q0PY50)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}.
Interaction partners:
- Presenilin-2
- Gamma-secretase subunit PEN-2
- Nicastrin
- Presenilin-1
- Anterior pharynx defective 1a homolog
- Transmembrane emp24 domain-containing protein 10
- Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 3
- Amyloid-beta precursor protein
- Notch homolog 4, isoform CRA_b.
Sequence:
MTAPVFFGCAFIAFGPALALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYRLLKKASEGLKSINPEETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSNALGPGTVGIHGDSPQFFLNSAFMTLVIIMLHVFWGIVFFDGCEKNKWYILLTVLLTHLLVSTQTLLSPHYEVNLVTAYIIMVLMGIWAFCVAGGSRRSLKLCLLCQDKDFLLYNQRSR
Protein: GH15292p (Q8T0P6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MQEMSYLQDNSKVEALTKAVLISILGVAIVLSNLLIIATYANFKGPTEVINYYLLSLAIADLLCGLLVVPFSVYPALTGEWMYGDIVCRFTGYLEVTLWAVSVYTFMWISVDRYLAVRKPLRYETVQTKTRCQCWMVFTWISAALLCCPPILGYSMPIENNMTHICMLDWGNMAAYSATLAILVLGPSLISIVHNYGYIFVMMRKIRSGEPIHDKEYATALAENLSNPSHMMSFALVFAFWVSWLPWILLRLYEVVTGDVIQSTLINFAVVWIGILNSFWKILIMTSMSPQFRIALRVFCLTICCRTRGRLQAELVGLDPDDWS
Protein: Non-POU domain-containing octamer-binding protein (Non-POU domain-containing, octamer-binding) (Q802Z5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
- Matrin 3-like 1.1
Sequence:
MQGNRGPRSEQQNHGPQRQQPNPQQEQQRKPTGADSNGQHTDAGEQSSPNAGFTIDLQNFKKPGEKTYTQRSRLFVGNLPAGTTEEDVEKLFSKYGKASEIFINKDRGFGFIRLETKTLADIAKAELDDTIFRGRQIRVRFATHGAALTVKNLPQFVSNELLEEAFSMFGPIERAIVIVDDRGRPTGKGIVEFANKPSARKALDRCGDGAFLLTAFPRPVTIEPMEQLDEEEGLPERLINKNPVYHKEREQPPRFAQPGSFEYEYAMRWKALMEMEKQQYEQVDRNIKEAKEKLETELEAARHEHQVMLMRQDLLRRQEELRRMEEAHSQEVQKRKQMELRQEEERRRREEELRAHSEELMRRQQGQGGNFSEKRDPDMRMHMGGQGMGMNRNPMGGNASNTGSTNLTSNEQGASGNPGGLPLPFPRPGPNDFGANKRRRF
Protein: Histone deacetylase (EC 3.5.1.98) (A0A1D8PSA6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR037913}.
Interaction partners:
- Transcriptional regulator
- Ume1p
- Chromatin modification-related protein EAF3
- histone deacetylase
- Transcriptional regulatory protein SDS3
- NAD-dependent histone deacetylase SIR2
- Histone acetyltransferase GCN5
- Histone H3.1/H3.2
- SIR4-interacting protein SIF2
- Histone H3.3
Sequence:
MYQELPFDELKVDPRKRRVAYFYDQDVGNYFYGTGHCMKPHRIRMAHSLIMNYELYKKMEIYRAQPATNLELTQFHTDEYIDFIDRVTPDNLHLFEREQVIFNVGDDCPVFDGLGEFCKISCGGSMEGAARLNRGQADIAINYAGGLHHAKKSEASGFCYTNDIVLGIIELLRYHPRVLYIDTDVHHGDGVEEAFYTNDRVMTCSFHKFGEFFPGTGNLTDIGIGKGKYHAINIPLRDGIDDASYKSIFEPIITKIMEWYQPSAIVLQCGGDSLSGDRLGPFNLSMRGHANCVNFVRSLGVPMMVLGGGGYTIRNVARTWAFETGVCNGEILPKELPYNGYYEYYAPTYELDVRSANMTNANSKEYLDKILTQVISNLDNTKHTPSVQMNEVPLDMEDLGDVDEDMPDAIDTKGGSQFAKDKLVQADGEFYDDDEKDKGEKNIQENGNVNTNANENGNGNGNVIITEEEQAELDKLNNNV
Protein: Pleckstrin homology domain containing, family G (with RhoGef domain) member 4 (F8VPS6)
Organism: Mus musculus (Mouse)
Interaction partners:
- BTB/POZ domain-containing protein KCTD19
Sequence:
MEGPLECGDVSPDSQGHVADGKRFAVCSFRNTRKEEEPAHEIQAMDPRPSRPAAGATQGVGLQGDFLAKEPQSLPEQRAEDGPRGYQRSIIGAPPTQSEEPAFSELENLLCSGSSHLNLTQGDNDYRGEGLIGDPGPGRTLPAGCSPLSETSPKLLEADPSGSSFPKPADCLLARDLAWELLASGMAALPGTRDVEGRAVLLLCAHSPAWLHPKSNSHELLSLLFYLRGIPRPEVQALGLTVLVDARVCSPSSSLTWGLSRLQEASPGSVQQVLLIGKMPEDVPVGLQWKQLRSHQSLLTHIPNVELPTSLGGSLSYCHQGWLDFRMRLEALQQSCQVACALLQGVIDSMKALRPPMESGEVAQLLQQTQSLMQQVLDSPQLSWLQSQGSQELAWLKQGTPRVTLSPDYRSAVDKADALYGQVDELLHQLALKSNQRIRALELLQALEAQEGVLRQIEVWLQEVGWPGVEEPGEPSLDTLLQAQGPFQELDLVAQEQVTQGEKLLQPLVGLEAAELGSPGKRFLALRSQLTEFSRALAQRRQRLADAEKLFQFFKQASTWTEEGRRLLTELEQERPEVVLQRLQLHWTRHPDLPPAHFRKMWALATGLGSEGIRQECRCAWAQCQDTWLALDQKREAALKPMPATNNTATLYVRRAPAVPTVPPLRKAYSFDRNLGRHLQDVSSRGHCAAIVTDCHRPEARGGVRPRSSPPVPLSGSSDFRSPNRLQLVLAEMVATEREYVRALDYTIQNYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHYNFFLRELEACTRHPPRVAHAFLRHRVQFGMYALYSKNKPRSDALMTNYGHTFFKEKQQALGDHLDLASYLLKPIQHMSKYALLLQELARACGGPAQELGALQAAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFTVRAGRHKACRRVFLFEELLLFSKPRRGPAGVDIFTYKRSFKMADLGLTECCGESQLRFEIWFRRRKARDLFVLQASDVATKQAWTADISRLLWRQAVHNKEVRMAEMASMGVGSKAFWDIAPSEEAINDRNINYVLKRRDVRSRASIAVAPFDCDNPYLGALGSLPGDRASGSVLGSLNLHLYRDPALMGGHWSLYPPNFSEEASLDLGSQPSLTPEDSEVSSQCPSASGSSDSDSSCVSGQTMGRGLEDLSCV
Protein: Somatostatin receptor type 1 subtype A (Q5G547)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDNMAANGTSNYPAYPTDFPYNSSLDYEDYDQEPDTSKIIIPSIYALVCCVGLTGNTMVIYVILKYAKMKTATNIYILNLAIADELFMLSVPFLATSAAVRHWPFGSLMCRLVLSVDGINMFTSIFCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNVCVWGLSLLVILPIIIFADTVPAQDGGVDCNFLWPEAAWSEAFVVYTFLLGFLLPVGAICLCYCLMVARMRAVGLKAGWLQRRRSEKKITRMVVCEVAVFVLCWMPFYIVQLVSVFHHPPNPMVTQLFVILSYANSGANPILYGFVSDNFRRSFQRIVCFRWLESGLDCEQVDYRAVALKRQATNGQKDFPKECLASDMVFRNGTYTSRTTTL
Protein: E3 ubiquitin-protein ligase goliath (EC 2.3.2.27) (Q06003)
Organism: Drosophila melanogaster (Fruit fly)
Function: Endosomal E3 ubiquitin-protein ligase that regulates the recycling endosome pathway. May play an indirect role in regulation of gene expression during embryonic mesoderm formation.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:23353890}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Ubiquitin thioesterase otubain-like
- Lipoyl synthase, mitochondrial
Sequence:
MYIRKTLLLACLVLLFGGLPPLTFPATTTTLVAAMSIANQDLERYFRPGNGTHSFSGMEDRIAVDVYNYAFLNWSYVEHGNMLCNMEFAQEQARYGEGKVLNVTGRLIHITATDNFSDDYACTPYIRGTLGAPIPDKGETWIALVRRGRCTFEEKVKHVYQQNAAGVIIYNDKQVMQLEKMQIKGKTRNIAAVITYQNIGQDLSLTLDKGYNVTISIIEGRRGVRTISSLNRTSVLFVSISFIVLMIISLVWLIFYYIQRFRYMQAKDQQSRNLCSVTKKAIMKIPTKTGKFSDEKDLDSDCCAICIEAYKPTDTIRILPCKHEFHKNCIDPWLIEHRTCPMCKLDVLKFYGYVFLGSEESILEYQPDPPQGLALVEARDESADLNRSRDFVVDFPRVFVLDSGCVVGAREMLFPCRIPERSQSSLSLRQARDWVSLMSNKLEEQQGLRSMRNDEMQQVIK
Protein: Beta-hexosaminidase (EC 3.2.1.52) (A2BHD8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000256|ARBA:ARBA00037865}. Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
- Alpha-galactosidase
- Alpha-galactosidase
- chitinase
- chitinase
- Chitinase, acidic.4
- Oviductal glycoprotein 1
- chitinase
- chitinase
- chitinase
- Zgc:113333.
Sequence:
MLCLLKFTPLFLVVAVCHGWLFGDLFEKQKELDEISLWPLPQKYQSSAVAFKLSAASFQIVHAKQSTAGPSCSLLENAFRRYFEYMFGELKRQEKSRKKAFDSDLSELQVWITSADPECDGYPSLRTDESYSLSVDETSAVLKAANVWGALRGLETFSQLVYEDDYGVRNINKTDISDFPRFAHRGILLDSSRHFLPLKVILANLEAMAMNKFNVFHWHIVDDPSFPFMSRTFPELSQKGAYHPFTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGNGIKDLLTPCYSGSSPSGSFGPVNPILNSSYEFMAQLFKEISTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMNQQGFGTDYSKLESFYIQRLLDIVAATKKGYMVWQEVFDNGVKLKDDTVVEVWKGNDMKEELQNVTGAGFTTILSAPWYLDYISYGQDWQRYYKVEPLDFTGTDAQKKLVIGGEACLWGEYVDATNLTPRLWPRASAVAERLWSDASVTDVGNAYTRLAQHRCRMVRRGIPAEPLFVGHCRHEYKGL
Protein: Uncharacterized WD repeat-containing protein C3H5.08c (Q6LA54)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MNGNLPHIQIQSPKNSLDHLNNGRQATHNFEHGKPGDREEANGHADAHSSSGRSRYLSSDTNLLRDGSSSLDPLSKHIMKRTRSEKTLSFLNPSRASSNTHLSREGTNRSSNVTRTVSGRKSNHGSSLTDTGESDQLSLKSFGAIRQPSQHRSSLFSRMLGSTSHIFGIREDMDNESSEEERDGIPRVEGNAADPFSWIPDGKNVWDSPPKYIRVLSHNKKEKSLDHLFLAQELYCKPTLAATHDRYYEPRATDFPNLAHESSEPSSSRHTADAQSITNASVHLHNSSSPLNRTPSVISDTLAVAITSNSSSNSSNNAIWAMKFSRDGRYLAVGGQDRILRIWAVLDSEHARSVASETCSSDPNNPKLNLKAPVFSEAPIREYAGHTADILDLSWSRNNFLLSSSMDKTARLWHPVRKDCLCCFEHSDFVTSIAFHPKDDRFFLSGSLDCKLRLWSIKEKAVSFWNELPELITAVAFSPDGGLAIAGTFVGLCLFYDTRGLRFRTQMSIRSSRGKNAKGSKVTGIQTRTQMIDNIAGDTEMLVTTNDSRIRIYNLRDKSLELKFKGHANAQSQNRAYFDDDGNYVICGSEDHQVFIWDLPPQHMHKTKKKKHEHFKASVRPITAAVFAPTKTKQLLTLSGDPVYLAAISARRSSVISNASIETGPSLRNLKSLSHSYLPIEIMKGHIIVCGDLDGRIRVFRQDSVFAARKLIEKKNIERKNSETLSNSSFFPQALKAHMNSISSPKRHFSLRHKKNASQITNNENNGNDDIKKGDEPEEEHVGLRKNSTQEKNANLDPNEALKRADMMMLQEGASSMVYYSLTNLDNPGATVNEAAKTAATIEQNEHEIQTSVDPISNVKAILPNADDVSSKNSSTEDQLECLRCGNSLFNVFSRSFVFEGAKFSIVCSHCNRKLLKSGSDDGSETHEMSTLP
Protein: DNA helicase (EC 3.6.4.12) (A0A2R8YFK9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLCRQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDGSQEDRDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPAEDGIKIEENSLKEEESIEGEKEVKSTAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEKAEVKERTEEPMETEPKGAADVEKVEEKSAIDLTPIVVEDKEEKKEEEEKKEVMLQNGETPKDLNDEKQKKNIKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANRAPEPTPQQVAQQQ
Protein: Endothelial cell surface-expressed chemotaxis and apoptosis regulator (Endothelial cell-specific chemotaxis regulator) (E7F0W6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Hemoglobin, alpha embryonic 1.3
Sequence:
MEKLLFFLIPLITFSSIISAGNDTNLTSPTPPSTVFSPTNSVNLTEAAQQIENSTTYDDDISNQTSKPTTVQFSRSTGESTSSSSFIRSTTPTTISKFYTDTSLNGVSASATKITEAVSSTTVFSNISMSEATATPSPAESRLTLLAFGVMSLILILIVVMVILVAAVNLKGRCCRNTQQHESIKNRDSLVSDSNLTSNGEKENITLVSVRTINTEYNADSPQISSVHSTIVDNDDHELSRDQLISLGS
Protein: Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)] (P56942)
Organism: Mus musculus (Mouse)
Function: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Melanin-concentrating hormone receptor 1
- Hypocretin neuropeptide precursor
- Pro-opiomelanocortin
- Pro-neuropeptide Y
- Oxytocin-neurophysin 1
- Galanin peptides
- Vasopressin-neurophysin 2-copeptin
- Agouti-related protein
- Pro-thyrotropin-releasing hormone
- Appetite-regulating hormone
Sequence:
MAKMTLSSYMLMLAFSLFSQGILLSASKSIRNLEDDIVFNTFRMGKAFQKEDTAERSVVAPSLEQYKNDESGFMNDDDNKNSKNTGSKQNLVTHGLPLSLAVKPYLALKGSVAFPAENGVQNAESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV
Protein: PPP1R8 protein (Protein phosphatase 1, regulatory (Inhibitor) subunit 8, isoform CRA_f) (cDNA FLJ60722, highly similar to Nuclear inhibitor of protein phosphatase 1) (cDNA, FLJ94432, Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit8 (PPP1R8), transcript variant 3, mRNA) (Q6ICT4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVQTAVVPVKKKRVEGPGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIHGTALIGGLPMPYPNLAPDVDLTPVVPSAVNMNPAPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTPSLLI
Protein: Farnesyl pyrophosphate synthase 1, mitochondrial (FPP synthase 1) (FPS 1) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase 1) (Dimethylallyltranstransferase 1) (EC 2.5.1.1) (Farnesyl diphosphate synthase 1) (Geranyltranstransferase 1) (Q09152)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Subcellular location: Mitochondrion. Cytoplasm.
Interaction partners:
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- Diphosphomevalonate decarboxylase MVD1, peroxisomal
- Diphosphomevalonate decarboxylase MVD2, peroxisomal
- Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial)
- Phytoene synthase 1, chloroplastic
- Hydroxymethylglutaryl-CoA synthase
- Dehydrodolichyl diphosphate synthase 1
- Squalene synthase 1
- Inactive squalene synthase 2
- Isopentenyl-diphosphate Delta-isomerase I, chloroplastic
Sequence:
MSVSCCCRNLGKTIKKAIPSHHLHLRSLGGSLYRRRIQSSSMETDLKSTFLNVYSVLKSDLLHDPSFEFTNESRLWVDRMLDYNVRGGKLNRGLSVVDSFKLLKQGNDLTEQEVFLSCALGWCIEWLQAYFLVLDDIMDNSVTRRGQPCWFRVPQVGMVAINDGILLRNHIHRILKKHFRDKPYYVDLVDLFNEVELQTACGQMIDLITTFEGEKDLAKYSLSIHRRIVQYKTAYYSFYLPVACALLMAGENLENHIDVKNVLVDMGIYFQVQDDYLDCFADPETLGKIGTDIEDFKCSWLVVKALERCSEEQTKILYENYGKPDPSNVAKVKDLYKELDLEGVFMEYESKSYEKLTGAIEGHQSKAIQAVLKSFLAKIYKRQK
Protein: Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (Q8R2U0)
Organism: Mus musculus (Mouse)
Function: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q96EE3}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q96EE3}. Lysosome membrane {ECO:0000250|UniProtKB:Q96EE3}.
Interaction partners:
- Protein SEC13 homolog
- Nuclear pore complex protein Nup98-Nup96
- Nucleoporin Nup37
- GATOR2 complex protein WDR59
- Nuclear pore complex protein Nup133
- Nucleoporin Nup43
- GATOR2 complex protein WDR24
- Nuclear pore complex protein Nup160
- GATOR1 complex protein NPRL2
- Nuclear pore complex protein Nup107
Sequence:
MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRVYEAPDVMNLSQWSLQHEVSCKLCCSCISWNPSSSRAHPPMIAVGSDDSSPNSMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAVATKDVRIFTLKPLRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQLGNSNPSLSSNIPNLQNSLNGTSASRKHS
Protein: Transcription termination factor 2 (EC 3.6.4.-) (Protein lodestar) (RNA polymerase II termination factor) (Transcription release factor 2) (P34739)
Organism: Drosophila melanogaster (Fruit fly)
Function: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- FI07206p
- Phosphoserine phosphatase
- Uncharacterized protein, isoform A
- Trifunctional purine biosynthetic protein adenosine-3
- Delta-1-pyrroline-5-carboxylate synthase
- Adenylosuccinate synthetase
Sequence:
MSSENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLKGLFGM