wanglab/gogpt-training-data huggingface dataset:
Protein: Antitoxin VapB4 (VapB-mt4) (P9WF21)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4.
Interaction partners:
- Ribonuclease VapC4
- Ribonuclease VapC5
- Ribonuclease VapC8
Sequence:
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTTDDVRW
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (A1Z850)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSIKMRRGDESYAGALRSALDGVGQVEIDTQEGRVIIQTQRPWSEIQDKIEATGVRAVLSGFGGQSAVALINTTGSVVDKTPIQGVVRFTTITADKKPGVVVDGVVDGLSPGLHGLHIHESGDTSAGCSSVGEHYNPRQSPHGSPAAGAEERHAGDLGNIRADENGRATFRFVDPVLEVWDIIGRAVVLTANADDLGRGGNDQSLIDGNSGERIACGIIARSAGILENFKRICACDGVTLWDERNKPLAGKERSQKL
Protein: HTH TFE/IIEalpha-type domain-containing protein (TFIIE-alpha protein) (G5EG49)
Organism: Caenorhabditis elegans
Interaction partners:
- Transcription initiation factor IIE subunit beta
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIH subunit 4
- BSD domain-containing protein
- General transcription factor IIH subunit 2
- DNA-directed RNA polymerase II subunit RPB1
- General transcription factor IIH subunit 3
- CDK-activating kinase assembly factor MAT1
- General transcription and DNA repair factor IIH helicase subunit XPD
- Transcription initiation factor IIF subunit alpha
Sequence:
MSSGPATSGSSSAHTETQVVDEIPEALNTILLMVVKNFFSSEHFIIVYHIMRAQCIREENLKARIQFDQKMLRQLLASLKAEKLVKERTITQKNENNRTVSIIFYYINYRAVLNVVRYKIDHMRQKLESREQMDTNRAHYRCGACQSSYDMLEINRILDAESGRLICWRCHGDVLADETVVPSRTTRTAVARFNEQMTPLFSHICALNGIQLAPHLLEPDITKYLEDDKELQLQQQQMDFTSGGGGGGRIQLGGVAHSYQNIASINYQNGDAVFVDLNADINKGPVEEAKIMPEWLKDNAIGGGEASHNEHVLDQAKTEEEETSTKQRRYGPSLDYLKEIECSSEESAPNVKIEEPPAKQIKMEVDEEAIKMEVDNDESEEEDLIHVAGRALPLSQITPRMVENEMSELEKESYCSVVQDLFAMFFSQQIAIH
Protein: polynucleotide adenylyltransferase (EC 2.7.7.19) (Q5B186)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Zinc knuckle domain protein
- ATP dependent RNA helicase
- RNA-binding protein
- RNA binding protein Nrd1, putative
Sequence:
MPPPAYEFRGGNHRPSHPRHEFTFRYQRPGTSERPLLRSRREVTPEQFIAPEAGNEKPAMKYARIENLSDSEEAEMEVSSDDEESHPRKKRALENNTSTADAPVESKPVPKWSNPDPYTALPPPDESQTKKIDVVKLIRKARLAVSAQPAKTDAVVSNEDFISLAGLVDDDETDKAPENAPKGPRRHLEGGDPALGNRKRTHDDEIKGPAKMGGKPVSRYYNDGSIIDEWKLRPSETGTPWLSLMPPTLHLGTRLHDEILSFYHWVKPVRYEHIVRQDLVARLQAAFQSRYYGVEIHAFGSFASGLYLPNADIDLVLLSTSFRRTGVKTFGERKGQIYAFSAFLKNQNIAVPGSVETIAHARVPILKFVDKLTGLKVDLSFDNDSGLIANRTFQQWKSEYPAMPVIVSVIKQFLLLRGLNEVPTLGLGGFSITCLVTSLLQHMPHGNLYPNLGSVLMDFFQFYGNNFDYETVGIRMNPPGYFNKRVYGVYKANNGARLSIEDPNNPDNDISGGTREIALIFKSFADAFRLLKDRLVSAAISGKTNESILGAIIAANFDEYTELRWQLREVFENDPRFAQYRKPPTPPPPPYSPPPPNQPAPPPPSETHPLPAKPSSGGRKTKETKEPKEKLTKLQKKKQASKDRAARLKRLRPDLENIPSSISNDEALKLGGYKTQSDMDKDLIMREKGLIAVS
Protein: Zinc finger BED domain-containing protein RICESLEEPER 2 (Transposase-like protein RICESLEEPER 2) (Q6AVI0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transposase-like protein that is essential for plant growth and development. May regulate global gene expression by recruiting other cellular factors.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MTEETGNDFQMVQGYEIVPSNEEAHAEEVQGDELVLAEDLAQGDEVQVNGLVSAEMSTPPTSRRRRKKSLVWEHFTIEAVSGGATRACCKLCKQTFAYSSGSKIAGTSHLKRHITLGSCPIIKNQEHKLALTPAVGTDNDGEGTVERPSKRRYRYTGYANAAFDQDRSCSYLAKMIILHDYPLHIVQQPAFTTFIDSLQPRFRVVDVETMEGEVYAVYQKEKENLMQAFSTMPGRISLTIGLWTTSQTLGYVSLAGQFIDSEWKIHRRMLNFMMVSSPHSENALSEAISTSLSDWNMKDKLFTITLDNDCSSHDIYSANLRDYLSNKNNLMLKGQLFVVRCYAHILNAVAQDVIASIHGVIYNIRESIKFIKASPSREEKFAEIALQLEIPSTKTLCLDVTTQWNTTYLMLLAALDYKQAFSTLETSDDNYNEAPSAEDWKKVEAACNYLKLLYDSAHSIMAAANPTSNLFFHEAWKLQLELSNATGHEDPVFSSIAKDMHERFDKYWKDCNLVLAIAVVMDPRFKMKLVEFSYSKIYGVEAAKYVKVVDDAVHELYKEYVAQPLPLTPAYVEQGDGNNAPASENGTQATAPSTGDGLVDFDMYLSEIATSQPTKSELEQYLDESLTPRIQEFDILNWWKLNTLKFPTLSRMARDILAIPMSMVSSGNSIFSAGTGTRMLDDYRSSLRPEIVEALVCAKDWLQYLPATPEAPSTTLVKVDAP
Protein: Nuclear pore complex protein Nup153 (Nucleoporin 153) (A0A0R4IVZ0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nucleoporin 50.
- Nucleoporin 214.
- Nuclear pore complex protein
- Nuclear pore complex protein Nup93
- Nucleoporin 155.
- Nuclear pore complex protein Nup133
- Nucleoporin 205.
- Nucleoporin NUP35
- Nucleoporin 88
- Nucleoporin 160.
Sequence:
MAATGGGKIRSRRHHIASKPYAKGKQQPGLITRVTDTVKSIVPSWLQKYFRNGEGPEGGASAAGVEHNNMTPPPNGSDEAPLRDGRDSPEPSTSNTEPSTSRASLNFQEALSRPPLNRTHLQFPSLDGSPALGGSSSLFSQPSTSTAPFSGSPFAVTSNFSLVKEIKDSSSQHEDDNISTTSGFSSRASDKDVPTSKTVPLLWSPETERTHSGSQTAHSGLKKPAFNLSVFGTSSSSVLNSSVLNSSQLGDSPFYPGKTTYGGASAMRTARSRPATPYQPPVRRQIKAKPTGAQPCGVTSATARRILQSLERMSSPLADAKRIPSTVSSPLSASLNHTDLDISNYQAKRKRLEPSVPPVQKLVVPAAAAVSGNRSISFRPSLTPGGVSRGVEKTSRETPVRQSPPISEPAQAPPPSTSTLSYPLSSTPAANSAALGGGKMKRERAIRPSSKRPDDEVAEEPDLPPASLPSNFTLPTFTFSTPPPTSSLKSSTAPLITVSEEPAANKQPAAPSTPPSAPFTFSSPIVKATAASPPSFSPSSGFTFSAPTMKMGPSFSNGKIVPSVAPVKSVVIEEKEFEGPFKPAKVLKQGSVLDILKGPGFASPSQNSTDKPLQSTSTTTSSPFSGFGDKFRPPAGSWNCGTCMLQNKPSDKKCVACLAPQPNTDSSKSDSKPAEAPASISSLFAPPAGSWECDTCLVSNKPDAVKCVACDTAKPGTGVKSSLTLLAASESSSSTTTTATTTAAALTSTGLLGLGDKFKKPEGAWDCDVCMVQNKAQDLKCVACLTAKPGAAAAPLSTPASAPVSSAAPLLGFGDKFKKPEGSWECDVCCVQNKADDQQCVACQSAKPGAKIESKGFSSSFGVQSNSTDSNTSGFKFGTGSTDSSSSSAGLKFGGTFSDSSTTGGIKFGFGLSSTSSEGFKFGGSSSDAGGAKLSSTLSESTATKESSTKSFAFGGSADDTLEKKSKTQESNTGFKFGGGSGMASGSENSSFLFGAKPSEKGSSNPSFSFPVPQSKVEKDAPSETPPVSNTTTTTTAANALPVFGKSLVAESSAPKFGEPATKEQTLVTSTFTFGKPEEKKDTSAPSSTFLFGSSKEAEKPTPNLGFAFSEPDPPKDFPKPALTFGKPAESTEPPKPSFGFGQSLTETSAPKPSFGFMANSTSSTPASSSSTPSLFGTPTTSSLAPTPAPTSTFVFGQNSSSELNVGKTFVFGQQQQDSQPAPPAAPSAAPAQPFQFGSGSNSSTPSFTFGAAASSTPASAAPAPSANPSPFVFSSAAPSSGFGSGQTPIFGQSASQPSAPAFGSAAPSFSASATPASTFGAKPSSAPVFGQQANAAPTFGSTAASTGQGGFQFGSTGGFGASATSNSVFNFGGGSAAPAASPAMPALNPPAGGGFGFSPTPAFNIGSAKSSFTASPAGQNSIAGRKIKTAVRRRK
Protein: Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Q9DBG9)
Organism: Mus musculus (Mouse)
Function: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12874278}. Nucleus {ECO:0000269|PubMed:12874278}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to the cell membrane by interaction with membrane proteins. {ECO:0000250}.
Interaction partners:
- Catenin beta-1
- PDZ domain-containing protein GIPC1
Sequence:
MSYTPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS
Protein: IP09768p (Q4QQ62)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MACGSEAIIMKFPMHMRAHLLAVLNDFRNTVAKGQYPHLRPASRMATLRWHEELAGLAKFALRRCDYIDDYCSNTDEFSYVSYIYGSTKWLQLEKDPISVLDFVLQFWMDDVKGCTMAHINAEKPAKDGQCRGYFTQLVQDLAAHVGCAMMLRKGQTSGLYQYGVLCHFSRGKIANELVYRASAHPGSRCYAGTHSIYEGLCSPEEHVNPNALQLGELN
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (H7C189)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHY
Protein: MutL homolog 1 (A0A669KB03)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC
Protein: TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (B5LZ55)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- High affinity immunoglobulin epsilon receptor subunit gamma
- IgE receptor gamma.
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- V-set and Ig domain-containing protein
- T-cell surface glycoprotein CD3 zeta chain
- Lymphocyte cytosolic protein 2
Sequence:
MGWILHSIALLSGLFGYVAATQDCGTCYQLNMMVVIGIITCDIILTLLITITVYCFASREKRKKSLRTHKNSSETDKGKFRQSSSKPKEVEITESPYQELYGVQSDIYSDLHQYRK
Protein: Protein GOLM2 (Golgi membrane protein 2) (A0A3B3IRW9)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPALRKPPISVSQHESHQAISHLPTGQPLSPNMPPDSHINHNGNPGTSKQNPSSPLQRLIPGSNLDSEPRIQTDILKQATKDRVSDFHKLKQSRFFDENESPVDPQHGSKLADYNGDDGNVGEYEADKQAELAYNEEEDGDGGEEDVQDDEERELQMDPADYGKQHFNDVL
Protein: Leucine-rich repeat-containing protein 26 (BK channel auxiliary gamma subunit LRRC26) (Cytokeratin-associated protein in cancer) (Q2I0M4)
Organism: Homo sapiens (Human)
Function: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000269|PubMed:15164053}.
Interaction partners:
- Calcium-activated potassium channel subunit alpha-1
- Calcium-activated potassium channel subunit beta-1
- Keratin, type II cytoskeletal 1
- Leucine-rich repeat-containing protein 58
Sequence:
MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTAALRPPRPPDPNPDPDPHGCASPADPGSPAAAAQA
Protein: Fanconi anemia complementation group G (A0A0S2Z3R2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKHILASRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLSWIRPSDRDAFLEEFRTSLPKSCDL
Protein: Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (Q8I592)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|HAMAP-Rule:MF_03061}.
Interaction partners:
- Small ribosomal subunit protein eS30
- Ribosomal protein S16, mitochondrial, putative
- 40S ribosomal protein S18, putative
- 40S ribosomal protein S11, putative
- 60S ribosomal protein L6, putative
- 40S ribosomal protein S11
- 40S ribosomal protein S3
- 60S ribosomal protein L5, putative
- 40S ribosomal protein S19
- 40S ribosomal protein S5, putative
Sequence:
MIILKHILYKNNGRRFFEKTIPNKIYNFYLSGLCKFSSCCIDNLRNIGISAHIDAGKTTLTERILYYTGKIKSIHEVRGNDGVGATMDSMELEREKGITIQSATTNCVWEINNKKYNINIIDTPGHVDFTIEVERSLRVLDSAILVICGVSGVQSQTLTVNRQMDRYHIPRILFINKLDRDGANVERTLHTIEKRLNLNTILLQMPIGIEQKFKGVYDLINRKGYLFQGKNGIILNEINNKEEILSLDNSFSFEIMELLRNRILEKLADVDDEFAEIYLNNDINDIKKNDIYSSIRKSTIKNLVTPICLGSAKNNVGVQILLNYVCNFLPSPKEINNYGYIIYSDVLEDKIKNNDICNETQNTQQYQSQDQNDISIINYNNQNSINNYTHKDDHHSSKNKSKKKIQLLCDNNLPMVGFLFKIQEDNMYGQMSYFRIYQGKIKKKEMITNMMTNKKEIVKKIMKMHSNMAKEVNEASAGDIVAICGINGSTGTTYTNGINTNLHLLNIFIPKPVISVAVEILKKGDMTKLTKALNKFTKEDPTFYVKTDEQTKETIFEGIGELQLEIYKERLKREFNINVNLKNPKINFKETITKPFECSYTYKKQKGGAGLYAHVHAIFETISDNYNDTTHCTFVNEVIGNDLPKNFILSIEKAFKEQIEKGYLYNSEIINMKMRLIGGKIHEVDSNDLAFKKATINLIKENYHNFCPVLLEPIMLVEIISNYEHQSNILTSITKRKGLVNNIVNNLNIIYIYADIPLKHMFNYINEIRAITQGQGTYTMEFSRYEQVSKNDLDEILKQKSTA
Protein: Transmembrane emp24 domain-containing protein 2 (COPI-coated vesicle membrane protein p24) (p24 family protein beta-1) (p24beta1) (P49020)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity).
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass type I membrane protein {ECO:0000255}. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000250|UniProtKB:Q15363}.
Interaction partners:
Sequence:
DVLVLLAALLATASGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV
Protein: Glucose-6-phosphate 1-dehydrogenase gcd1 (G6PD) (EC 1.1.1.49) (O59812)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable 6-phosphogluconolactonase
- 6-phosphogluconate dehydrogenase, decarboxylating
- Glucose-6-phosphate isomerase
- Hexokinase-2
- Hexokinase-1
- Glucose-6-phosphate 1-dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase 2
- Probable glucose-6-phosphate 1-dehydrogenase C7.13c
- Glyceraldehyde-3-phosphate dehydrogenase 1
- Triosephosphate isomerase
Sequence:
MLSIIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIVTAHIPIDDTVGASQKALNTFVEHYKYVPGTYDKPESFEMLNSIIAEKETAPASECTRIFYLVLPPHLFAPVSELIKSKAHPNGMVTRLIVEKPIGFDYKSADAILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQNHLLQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDIVYGQYTKSANGKVPGYRELDGVADDSEVSTFCALQLRSEAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFPTVDSSNVLVLRVYPKEFIALKGHIKQPGFSRQIVPVTLDVKYPEAFPDTWIHKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDTTGDLSPLPYAFGSHHGPDATLEFFKKRNLEWD
Protein: Fumble, isoform F (EC 2.7.1.33) (MIP21736p) (D8FT20)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDNVEIRKRRGSLHFIRFQTTDMGNFLSLAKQKGMAELVTTVCATGGGAFKFEQDFRDQVNMKLAKFDELDTLIKGILFADLHNRTECYYYENARDILKSEKQQFNFSQPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVSVSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQFNGELAAALNDGVEHSIHTESDSASEAAQTSSTADEPPEKAPTSKHSTR
Protein: Uncharacterized RNA-binding protein C428.12c (O94359)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MERRKATVHVGNLAPSVTESLLYNAFIPFGEIISVALHRKEKAVDRSYAFVEFDEPEDAKEAMENMNYSILCDRCIRVSPANFALSAEETAVPDIAMLHPESADFQTFKSTSTPTS
Protein: Dihydrofolate reductase 2, mitochondrial (Dihydrofolate reductase, mitochondrial) (EC 1.5.1.3) (Dihydrofolate reductase-like protein 1) (Q86XF0)
Organism: Homo sapiens (Human)
Function: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188}. Mitochondrion matrix {ECO:0000269|PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}.
Interaction partners:
- Thymidylate synthase
- Folylpolyglutamate synthase, mitochondrial
- Serine hydroxymethyltransferase, cytosolic
- Trifunctional purine biosynthetic protein adenosine-3
- Serine hydroxymethyltransferase, mitochondrial
- C-1-tetrahydrofolate synthase, cytoplasmic
- Sepiapterin reductase
- Carbonyl reductase 1])
- Dihydropteridine reductase
- Bifunctional purine biosynthesis protein ATIC
Sequence:
MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSSVYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKFEVCEKDD
Protein: Proteasome subunit alpha type (G3V5Z7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Interaction partners:
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCWSFLFLGMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
Protein: Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I) (Q55CT0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Serine protease with tripeptidyl-peptidase I activity.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Cathepsin D
- Ceroid-lipofuscinosis neuronal protein 5 homolog
- Cysteine proteinase 1
- Battenin
Sequence:
MNIKFNLIIIILFILFISNVNCKKIKNKKHLTPQRLRRFVEHSKPISLNKKVWKITEIENIFSAQIELTFGIRQRNIVELEDFVWRVSDPNDSLYGSYKTFEEIKEWVKPLDESIDAVKNWLIENDINEFTVTKSGDFIRTIVSIDKAEELLSVRYNKMVHKLSKQSFFRSLDPYTIPRELYDHIDFIGGVNHLPLLSPRPKESSGSAGGGGGGKVNGIGYELESLRNNKQIKSFNDKKVAARNGDPYLSPDLIRKEMNVSQTSTNSTHLGNSQAIAQFLKEYFSPSDLKIFQYRFGLEPSQVDNIIGPNQNLNPGIETALDIQYIMAMAPDVPTWIVSTGGLHEGQEPFLDWLVDLSSNPKLPLVHSISYGDDESSIGLAYTDRVDTEFKKYAAMGRTIVFSSGDFGVGCNDDCDSFSPGWPASSRFVLAVGGVIKKKDGSIIGDEISGGGFSNYFSRPWYQVDECSSYIEWLNGSLSSFYNQSGRGFPDISSFSENVVILYKDKLMPIGGTSASAPIIAGLLSLINDQRLQKNQSPIGLFNPLLYKIARDHPNSFLDIDFGENNYKCCTNGFKSKSGWDPVTGLGLPNFDELVKYCLE
Protein: Transcriptional regulator SUPERMAN (Q38895)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcriptional regulator considered as cadastral protein that acts indirectly to prevent the B class homeotic proteins APETALA3 and perhaps PISTILLATA from acting in the gynoecial whorl. Principal function is to balance cell proliferation in the third and fourth whorls of developing flowers thereby maintaining the boundary between stamens and carpels. May fulfill this role by repressing genes implicated in cell division. Plays equally a role in the determinacy of the floral meristem. Is also required for normal ovule development.
Subcellular location: Nucleus.
Interaction partners:
- C2H2-like zinc finger protein
- C2H2-like zinc finger protein
- Defensin-like protein 97
- Uncharacterized protein
- SWI-SNF-related chromatin binding protein
Sequence:
MERSNSIELRNSFYGRARTSPWSYGDYDNCQQDHDYLLGFSWPPRSYTCSFCKREFRSAQALGGHMNVHRRDRARLRLQQSPSSSSTPSPPYPNPNYSYSTMANSPPPHHSPLTLFPTLSPPSSPRYRAGLIRSLSPKSKHTPENACKTKKSSLLVEAGEATRFTSKDACKILRNDEIISLELEIGLINESEQDLDLELRLGFA
Protein: Large ribosomal subunit protein eL28 (60S ribosomal protein L28) (P46779)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}.
Interaction partners:
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL20
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL21
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL37
Sequence:
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKRTRPTKSS