wanglab/gogpt-training-data huggingface dataset:
Protein: Lipase LipV (EC 3.1.1.1) (L0TC47)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Lipase that displays broad substrate specificity and preferentially hydrolyzes p-nitrophenyl myristate in vitro. Also shows significant activity with pNP-butyrate (68%), pNP-octanoate (82%), pNP-decanoate (90%), and pNP-laurate (74%). Is probably involved in lipid catabolism. Is active at low pH, and might play some important role in mycobacterial biology in macrophages where the bacteria encounters acidic stress.
Interaction partners:
- Possible DNA-methyltransferase
- Putative amidase AmiB2
- Probable lipase LipE
- Putative non-heme bromoperoxidase BpoC
- Putative hydrolase LipZ
- Protein Rv1367c
Sequence:
MIIDLHVQRYGPSGPARVLTIHGVTEHGRIWHRLAHHLPEIPIAAPDLLGHGRSPWAAPWTIDANVSALAALLDNQGDGPVVVVGHSFGGAVAMHLAAARPDQVAALVLLDPAVALDGSRVREVVDAMLASPDYLDPAEARAEKATGAWADVDPPVLDAELDEHLVALPNGRYGWRISLPAMVCYWSELARDIVLPPVGTATTLVRAVRASPAYVSDQLLAALDKRLGADFELLDFDCGHMVPQAKPTEVAAVIRSRLGPR
Protein: DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide) (Q9NVU0)
Organism: Homo sapiens (Human)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:33335104}.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC4
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC7
- DNA-directed RNA polymerase III subunit RPC8
- DNA-directed RNA polymerase III subunit RPC9
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase III subunit RPC1
- DNA-directed RNA polymerase III subunit RPC10
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerase III subunit RPC6
Sequence:
MANEEDDPVVQEIDVYLAKSLAEKLYLFQYPVRPASMTYDDIPHLSAKIKPKQQKVELEMAIDTLNPNYCRSKGEQIALNVDGACADETSTYSSKLMDKQTFCSSQTTSNTSRYAAALYRQGELHLTPLHGILQLRPSFSYLDKADAKHREREAANEAGDSSQDEAEDDVKQITVRFSRPESEQARQRRVQSYEFLQKKHAEEPWVHLHYYGLRDSRSEHERQYLLCPGSSGVENTELVKSPSEYLMMLMPPSQEEEKDKPVAPSNVLSMAQLRTLPLADQIKILMKNVKVMPFANLMSLLGPSIDSVAVLRGIQKVAMLVQGNWVVKSDILYPKDSSSPHSGVPAEVLCRGRDFVMWKFTQSRWVVRKEVATVTKLCAEDVKDFLEHMAVVRINKGWEFILPYDGEFIKKHPDVVQRQHMLWTGIQAKLEKVYNLVKETMPKKPDAQSGPAGLVCGDQRIQVAKTKAQQNHALLERELQRRKEQLRVPAVPPGVRIKEEPVSEEGEEDEEQEAEEEPMDTSPSGLHSKLANGLPLGRAAGTDSFNGHPPQGCASTPVARELKAFVEATFQRQFVLTLSELKRLFNLHLASLPPGHTLFSGISDRMLQDTVLAAGCKQILVPFPPQTAASPDEQKVFALWESGDMSDQHRQVLLEIFSKNYRVRRNMIQSRLTQECGEDLSKQEVDKVLKDCCVSYGGMWYLKGTVQS
Protein: Uncharacterized protein (Q388U7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proteasome regulatory non-ATP-ase subunit 9
- Proteasome regulatory ATPase subunit 1
- Proteasome regulatory non-ATP-ase subunit 7
- Proteasome regulatory non-ATP-ase subunit 2
- Protease regulatory ATPase subunit 4
- Proteasome regulatory ATPase subunit 3
- Probable 26S proteasome regulatory subunit rpn-6.2
- 26S proteasome regulatory subunit 4 homolog
- Proteasome regulatory non-ATP-ase subunit 5
- Proteasome regulatory ATPase subunit 6
Sequence:
MSDHLSEICKSDEIDAVLECLKRLCPGRAVVIDASSDLKEDEDGGPTLFCQAANISFESHIVAQHSFGGAWSHQDDDGRTALHWAVAMQSYSLAGKLMSAPYHALVYSVDHDGASPFLTACMVGAPIQFLTTILSKAAEQRRWNVAQQLFWDSKRGEASVNTEEPLAEHRIAVVNQPDNSGNTPLLHAASRGRLTIVSFLLQSGAFIAHTNKRGQSALHRAIGRGSLDVVEELVGASRKRHTEVEHKRWINLQDYRGDTALFYASMDNNEELGRYLLRQGADRNVRNKEGKEFWEV
Protein: Autophagy-related protein 8-like protein DDB_G0290491 (Q54G11)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Interaction partners:
- PB1 domain-containing protein
- ZZ-type zinc finger-containing protein
- Autophagy-related protein 3
- Ubiquitin-like modifier-activating enzyme atg7
- Cysteine protease
- Cysteine protease atg4
- Serine/threonine-protein kinase atg1
- Autophagy-related protein 8
- Ubiquitin-like protein atg12
- Autophagy protein 5
Sequence:
MALLSKSFKQEYSLEKRKLISSKIRNRYKDRLPIIVERAANSDVPDINKKKFLAPSNMVITNFIMEIRKHLDDSDHNEQKAIFLFVNKNNLPPSSQLLSSIYDAHKDEDGFLYICYSGENTFGSDI
Protein: Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269) (Q02223)
Organism: Homo sapiens (Human)
Function: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Subcellular location: Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 13B
- Marginal zone B- and B1-cell-specific protein
- Tumor necrosis factor ligand superfamily member 13
- Tumor necrosis factor receptor superfamily member 13B
- Tumor necrosis factor receptor superfamily member 13C
- CD40 ligand
- Immunoglobulin J chain
- POU domain class 2-associating factor 1
- CD27 antigen
- Tumor necrosis factor receptor superfamily member 5
Sequence:
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR
Protein: Microtubule-associated protein RP/EB family member 1A (APC-binding protein EB1A) (End-binding protein 1A) (AtEB1A) (Protein ATEB1 homolog 2) (AtEB1H2) (Q7XJ60)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. May be involved in anchoring microtubules to their nucleation sites and/or functioning as a reservoir for distribution to the growing end. In plants, microtubule minus ends are not necessarily severed from the nucleation site and transported to the plus end of a microtubule as part of the recycling process. May play a role in endomembrane organization during polarized growth of plant cells. Interacts with the tobamovirus movement protein (MP) and may play a role in the association of MP with the microtubule system during infection.
Subcellular location: Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, phragmoplast. Note=Localizes both to the plus ends of microtubules and to the sites of nucleation during division and interphase.
Interaction partners:
- CLIP-associated protein
- Mitotic spindle checkpoint protein MAD2
- Serine/threonine-protein kinase Aurora-2
- Tubulin alpha-6 chain
- Mitotic checkpoint protein BUB3.2
- Mitotic checkpoint protein BUB3.1
- 65-kDa microtubule-associated protein 2
- 65-kDa microtubule-associated protein 1
- Serine/threonine-protein kinase Aurora-1
- 65-kDa microtubule-associated protein 4
Sequence:
MATNIGMMDSAYFVGRNEILTWINDRLHLNLSRVEEAASGAVQCQMLDMTFPGVVPMHKVNFDAKNEYDMIQNYKVLQDVFNKLKITKPLEINRLVKGRPLDNLEFLQWLKRFCDSINGGIMNENYNPVERRSRNGKERSVKGSNKIPKSLQTNNNHPPPNSSSVGLSKASGPKSAKAAEVQALSKELVDLKISTDLLEKERDFYFSKLRDVEILCQTPELDDLPIVVAVKKILYATDANESALEDAQEYLNQSLGVEDDEAEGNGEQLEEEKTQA
Protein: Sestrin-1 (EC 1.11.1.-) (P58006)
Organism: Mus musculus (Mouse)
Function: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y6P5}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y6P5}.
Interaction partners:
- GATOR2 complex protein WDR24
- Sestrin-2
- Sestrin-3
- GATOR1 complex protein DEPDC5
- Nucleoporin SEH1
- GATOR2 complex protein MIOS
- GATOR2 complex protein WDR59
- GATOR1 complex protein NPRL3
- GATOR1 complex protein NPRL2
- Cytosolic arginine sensor for mTORC1 subunit 1
Sequence:
MRLAAASNEAYAASLAVSELLSCHQCGGDRGQDEELGIRIPRPLGHGPSRFIPEKEMLQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVSDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMQVNSAGNASVSDSFFEVEALMEKMRQLQECREEEEASQEEMASRFEMEKRESMFVFSSDDDEVTPARDVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT
Protein: MAPK kinase substrate protein At1g80180 (Q9SSC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in the regulation of stomata patterning.
Interaction partners:
- Probable carboxylesterase 3
- CAP superfamily protein
- At5g01740 family protein)
Sequence:
MAGLQRSTISFRRQGSSGIVWDDRLIAELSQQAANDRKGETLQQDEQAKLITSEVQDQTTKPIAGEGLKPIRTDGGMERSRSNGGGAIRHHRNTGRVSPAVDPPSPRLSAFGCCSAFGKKQPGKKVNQRKRPAKRRSR
Protein: Regulator of G-protein signaling 2 (Q6DG95)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MTEQSQIKKKSWRPRIFFSTLPLKESQNTSPQKKSHLPTTEEVSQWAQSLDNLLSSKCGLNFFRLFIKSELCEENLDFWLACEEFRKIRSRSKLKSKAKSIYNEFIKPDSPKEINLDYNMKEMLQQSLLIPTPCTFKVAQHRVLYLMEHNSYPRFLESELYQTLCRLAEGKQ
Protein: Endoregulin (ELN) (Small integral membrane protein 6) (Q3U0I6)
Organism: Mus musculus (Mouse)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27923914}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN
- Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF
- Myoregulin
Sequence:
MGQMVPPRSIQNEDFWKNPWDVGGLTVIGLFTSTFLLFVLFAVVFGYVEKAVFEEE
Protein: Lipid-anchored protein YDL012C (C-terminally palmitoylated protein CPP1) (Cysteine-rich protein CPP1) (Q12489)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cell membrane {ECO:0000269|PubMed:12514182, ECO:0000269|PubMed:14562095}; Lipid-anchor {ECO:0000250|UniProtKB:P38216}.
Interaction partners:
- Lipid-anchored plasma membrane protein CPP2
- Putative uncharacterized protein YDL057W
- Uncharacterized protein YHR202W
Sequence:
MSAQDYYGNSASKQSYSRPSAPPPGYETASRGYAPSQSQQNYYPPQQQQQQYQQQPQYYQQQQPQYYQQHPQQPIYVQQQPASSGNEDCLAGCLAGLCLCCTLDMLF
Protein: L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) (P07864)
Organism: Homo sapiens (Human)
Function: Possible role in sperm motility.
Subcellular location: Cytoplasm.
Interaction partners:
- Pyruvate kinase PKLR
- L-lactate dehydrogenase A chain
- Pyruvate kinase PKM
- Putative aspartate aminotransferase, cytoplasmic 2
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Pyruvate carboxylase, mitochondrial
- Citrate synthase, mitochondrial
- NADP-dependent malic enzyme, mitochondrial
- Tumor susceptibility gene 101 protein
Sequence:
MSTVKEQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDLADELALVDVALDKLKGEMMDLQHGSLFFSTSKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSPDCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLNSEEEALFKKSAETLWNIQKDLIF
Protein: PWWP domain-containing protein 3 (Q9FNE4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with PDP1, PDP2 and PDP6, interacts with MSI4/FVE and MSI5 to suppress FLC, MAF4 and MAF5 expression by regulating the function of the PRC2 complex and modulating H3K27me3 level, thereby promoting flowering.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- WD-40 repeat-containing protein MSI4
- WD-40 repeat-containing protein MSI5
- PWWP domain-containing protein 2
- Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1
- PWWP domain-containing protein 1
- VIN3-like protein 2
- PWWP domain-containing protein 5
- Putative E3 ubiquitin-protein ligase RING1b
- PWWP domain-containing protein 4
- PWWP domain-containing protein 6
Sequence:
MEIEVVLGIGEDAGPKPCSAEIESAEKTLKDDGVVQENGVRVSDNGEKKSDVVVDVDEKNEKNLNESGVIEDCVMNGVSSLLKLKEDVEEEEEEEEEEEEEEEDGEDEEEEEEEEEEEEEEEHGYCVGDFVWGKIKNHPWWPGQIYDPSDASDLALKIKQKGKLLVACFGDGTFAWCGASQLKPFAESFKECSKVSNSRSFLGAVEEAVEEIGRHIERVLVCDCAEEKKHEFDSPLVNNAGIKEGVLVRDVRREMISSLLIGKHGEILKDVKSFAETVSFSGLLELEILKRKVSAFYRSNRGYGLTEYHEPQSVPGLEDKNNDDDDDDEEKNVNDGLQWRAKRSRVEEVAALDHEESSSLQRSLEKCSGFPDHRLPHRRKEKSITEIIEKESAAKVRFETEPADGDVKSNVKSGRKKTKRHDEVNGDLENVTTTALWRRRKSEVATIEDGGNKQVVESSKGKTSRKKKKMDVDDGDDDGSGDKEESEEKEISDLEINIDSTSLASLRKKVRFDDSVVERSTENGETATQTSKRERKKSKYLSPDFLSDFSRKGRKKSTIESESSKVSSQSQVDERVTDASDSLMEVEEDTLDKPCEPSSDNGLGQEELSRELSNAVDFLRLGATPKEMQDLIRVAALGTQYPKDSSSRDMVREFMTIYRSFTYHDGANHKFLGSYDSSDKEKEELSEMGKPVTKGKEKKDKKGKAKQKAEEIEVTGKEENETDKHGKMKKERKRKKSESKKEGGEGEETQKEANESTKKERKRKKSESKKQSDGEEETQKEPSESTKKERKRKNPESKKKAEAVEEEETRKESVESTKKERKRKKPKHDEEEVPNETEKPEKKKKKKREGKSKKKETETEFSGAELYVTFGPGSSLPKKEDLIEIYEKFGALDKERTDTVDNNFSAHVAFLDVADGEKAFESSLEKCPFTSNSTVKFRLKYPNERTEEKKTEAEVAETTMEVEYLKKKLDEMKLLLDGCEGGMTEEVKVKLEGEMVNLLEKVIEMRSS
Protein: RNA-binding protein, mRNA-processing factor 2a (rbpms2a) (Heart and RRM expressed sequence) (hermes) (Protein hermes A) (Q6DH13)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (By similarity). RNA-binding protein localized in Balbiani body (electron-dense aggregates in the oocyte) and germ plasm during oogenesis, and may be required to maintain germ plasm mRNA translational repression. Translational regulator during topographic map formation in the visual system. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18582455}. Nucleus {ECO:0000250|UniProtKB:Q6ZRY4}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q6ZRY4}. Note=Localizes to the Balbiani body during oogenesis. {ECO:0000269|PubMed:18582455}.
Interaction partners:
- Nucleolysin TIAR
Sequence:
MSLKSDSETNTSVSLEEEVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVTFDSRSGAEAAKNALNGIRFDPESPQTLRLEFAKANTKMAKSKLMATPNPSNLHPALGAHFIARDPYDLTGAALIPASPEAWAPYPLYTTELTPGLPHAAFTYPAAAAAAAALHAQMRWYPSPSESSQPGWKSRQFC
Protein: Membrane-spanning 4-domains subfamily A member 10 (Q99N03)
Organism: Mus musculus (Mouse)
Function: May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MAGQAPTAVPGSVTGEVSRWQNLGPAQPAQKVAQPQNLVPDGHLEKALEGSDLLQKLGGFHIAIAFAHLAFGGYLISTVKNLHLVVLKCWYPLWGTVSFLVAGMAAMTTVTFPKTSLKVLCVIANVISLFCALAGFFVIAKDLFLEGPFPWPIWRPYPEPTTYIQRLELTLFCFTFLEIFLSGSTAITAYRMKRLQAEDKDDTPFVPDTPMELKGLSLGPPPSYKDVAQGHSSSDTGRALATSSGLLLASDSFHQALLHTGPRTLRK
Protein: Mucolipin 1.2 (Mucolipin TRP cation channel 1b) (Mucolipin-1b) (E7FBN6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004337}.
Interaction partners:
- Mucolipin TRP cation channel 1a
Sequence:
MASSFHRPSAQAATEKERLLTPVMGYGSGDLNGGPLDLCSLGSQQQQQDEEEALRRKLKYFFMSPCDKYHAKGRKPYKLALQLLKIIIVTVQLVMFGLSNQMVVAFKEENTDSFKHLFLRDYVEDSQEPLCLHTQKQVHEHIRYAIDQYLILSQTSVGRYAYVPGVGPNSSALYLCQRYFKKGTIDPVNDTFDIDPHVITDCFGVNPSDPSSPVQDLYPNITLNFQKLVNVTIEFQLKAINIQTIINNEIPDCYTFSITILFDNKAHSGKVKLSLLNEAFIKECRDPNVSGHGDSYARVAFDVLVAVVCGLSLVLCGRSILKGIMLQHELVCYFRVSLGRSVSLGDRLEFINGWYLLLIISDVLTIIASFIKIAIETKNLSSYDVCSILMGTSTLLVWVGVIRYFSFFQKYNILIVTLRAAFPNVIRFCCCAAAIYMGYCFCGWIVLGPYHAKFRSLSTVSECLFSLINGDDMFATFSEVEQSGTLVWVFSQIYLYTFISLFIYMVLSLFIALITGAYDTITQQTQDVPQVSELHRFIAECTDTPTSGNFRSPEPSTCSLFCCFS
Protein: Wilms tumor protein (WT33) (P19544)
Organism: Homo sapiens (Human)
Function: Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:15520190}. Nucleus, nucleolus. Cytoplasm {ECO:0000250}. Note=Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm. {ECO:0000250, ECO:0000269|PubMed:15520190}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus speckle {ECO:0000269|PubMed:15520190}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleoplasm {ECO:0000269|PubMed:15520190}.
Interaction partners:
- Pre-mRNA-splicing regulator WTAP
- Cellular tumor antigen p53
- Steroidogenic factor 1
- Sex-determining region Y protein
- Nephrin
- Transcription factor GATA-4
- Podocin
- Transcription factor SOX-9
- Nuclear receptor subfamily 0 group B member 1
- PRKC apoptosis WT1 regulator protein
Sequence:
MGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
Protein: Ras-related protein Rab-14 (EC 3.6.5.2) (Q93874)
Organism: Caenorhabditis elegans
Subcellular location: Early endosome membrane {ECO:0000256|ARBA:ARBA00004438}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004438}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004438}. Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004387}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004387}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004387}.
Interaction partners:
- Rab GDP dissociation inhibitor
- PH domain-containing protein
- Rab proteins geranylgeranyltransferase component A 1
- Vacuolar fusion protein CCZ1 homolog
- Vacuolar fusion protein MON1 homolog
Sequence:
MTAAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLADAKSLTNPNTAIFLIGNKADLEDQRDVPYEEAKAFAEENGLTFLECSAKTGSNVEDAFLETAKQIYQNIQDGSLDLNAADTGVQPKQNLPRAAENNGKKDCNC
Protein: TPD52L2 protein (Tumor protein D52-like 2, isoform CRA_a) (cDNA, FLJ95317, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), mRNA) (Q6FGS1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDSAGQDINLNSPNKGLLSDSMTDVPVDTGVAARTPAVEGLTEAEEEELRAELTKVEEEIVTLRQVLAAKERHCGELKRRLGLSTLGELKQNLSRSWHDVQVSSAYVKTSEKLGEWNEKVTQSDLYKKTQETLSQAGQKTSAALSTVGSAISRKLGDMRNSATFKSFEDRVGTIKSKVVGDRENGSDNLPSSAGSGDKPLSDPAPF
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q38CU4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MQGTMYWVVFLVAVLQGIHLVSGQEEILNEQEFEALCRMINWAERGLKHIKVTKRVTQEALKIGVRYLEVAGEENAAELAEAQDYSCTKRMEDRKRNCGLYKTFWEEAQRVLNKGVDSGERPERKKNGLREHSAEIRKKAMEVADIYHEIEAKSPSGQVEKIEEQLNKALYGRTHTAEEIREREERSRVCGKTLPNPPNREDQSLAVDLLCLCAMHGSWNGREICCADCTTGRNSEEWNPESNSAHRWEFLKQKCAGVIPSYGSTGERLRDAKQNFMDAVTKITTRRGEQLSKLGEKQNNNVKDCGADTSKSQGICMLYGAVDGVNLPWMKTLESVEDRIGLLMQESQDKTSKLERIKELSQEIESLIKGDTGRGRQQGRQKRSVDTENSVPETPADPSDPTQSTTDTNRKKQGERKPISTGNGASKSYGGDEVDSYDSKCDGENSACSDSPAKPTVKSSKSAINCPLGLILLLV
Protein: Hyaluronidase (Hya) (EC 3.2.1.35) (Hyaluronoglucosaminidase) (P86687)
Organism: Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)
Function: Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.
Subcellular location: Secreted {ECO:0000269|Ref.1}.
Interaction partners:
Sequence:
GETISIYYDPGKFPALMPLKNGNYEERNGGVPQRGNITIHLQQFNEDLDKMTPDKNFGGIGVIDFERWKPIFRQNWGNTEIHKKYSIELVRYEHPKWSESMIEAEATKKFEKYARLFMEETLKLAKKTRKRAKWGYYGFPYCYNYTPNNPGPDCDAKAMIENDRLSWMYNNQEILFPSVYVRHELTPDQRVYLVQGRIKEAVRISNNLKHSPKVLSYWWYVYQDKMDIFLSETDVKKTFQEIVTNGGDGIIIWGSSSDVNSLSKCKRLREYLLNTLGPFAVNVTETVN
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (A0A2R8Y6V2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED
Protein: Inositol-tetrakisphosphate 1-kinase 1 (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase 1) (AtItpk-1) (Inositol-triphosphate 5/6-kinase 1) (Ins(1,3,4)P(3) 5/6-kinase 1) (EC 2.7.1.159) (Q9SBA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway.
Interaction partners:
- Inositol-pentakisphosphate 2-kinase
- Inositol polyphosphate multikinase beta
- Inositol polyphosphate multikinase alpha
- Inositol-pentakisphosphate 2-kinase
- Inositol-pentakisphosphate 2-kinase
- Multiple inositol polyphosphate phosphatase 1
- Probable 3'
- 3',5'-bisphosphate nucleotidase 2
- Probable 3'
- Inositol 1,3,4-trisphosphate 5/6-kinase 4
Sequence:
MSDSIQERYLVGYALAAKKQHSFIQPSLIEHSRQRGIDLVKLDPTKSLLEQGKLDCIIHKLYDVYWKENLHEFREKCPGVPVIDLPEAIERLHNRVSMLEVITQLRFPVSDSERFGVPEQVVVMDSSVLSGGGALGELKFPVIAKPLDADGSAKSHKMFLIYDQEGMKILKAPIVLQEFVNHGGVIFKVYVVGDHVKCVKRRSLPDISEEKIGTSKGSLPFSQISNLTAQEDKNIEYGEDRSLEKVEMPPLSFLTDLAKAMRESMGLNLFNFDVIRDAKDANRYLIIDINYFPGYAKMPSYEPVLTEFFWDMVTKKNHV