wanglab/gogpt-training-data huggingface dataset:
Protein: Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6) (O43657)
Organism: Homo sapiens (Human)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Syntenin-1
Sequence:
MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIATGTVIILLGTFGCFATCRASAWMLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV
Protein: Origin of replication complex subunit 1 (OsORC1) (Q5SMU7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Essential protein (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that regulates positively the transcription of a subset of genes (By similarity). Required for cell proliferation.
Subcellular location: Nucleus {ECO:0000269|PubMed:15939553}.
Interaction partners:
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM7
- Probable DNA helicase MCM8
- Origin of replication complex subunit 6
- Origin of replication complex subunit 1
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM5
- Origin of replication complex subunit 3
- Cell division control protein 6 homolog
- Origin of replication complex subunit 2
Sequence:
MDLSATPSRSKSGLRSSPRKPVAAPAVAQMDLSTPSKPTPRRKPKAPPVAAPMSPVTPSSVRRSSRLLETPTKVTSETPVKPTPTPKRKRAAPSPSPKTPTQSEPKRQRQRQRQRQQPKKPKKRAYYRKVVYDGGEFAAGDDVYVKRRDGAESDAEDPEAEECRVCFRAGAAVMVECDVCLGGFHLRCVRPPLRRVPEGDWACPYCEAERAGKAIERPKPPEGKRIVRTAKEKLLSSDLWAARIESLWREPDGIFWAKVRWYIIPEETAAGRQPHNLRRELYRTNDLADIEMETILRHCYVMSPKEFKDASDQGDDVFYCEYEYDIHWHNFKRLADIDDEPETKEDPGDEPYNAGNDYVSDSDEDSEYDEEEEPTKCSSARTHQSHALAANLRKGRTYGLQKIGIRKIPEHVRCHQKTNLEKAKATLLLATLPKSLPCRDKEMEEISAFVKDAICNDQCLGRCLYIHGVPGTGKTMSVLAVMRRLRSELDSGNLRPYSFIEINGLKLASPENIYKVIYEQLSGHRVGWKKALHYLTEHFSGGTKIGKQANQPIILLIDELDLLLTRNQSVLYNILDWPTRPNSNLVVIGIANTMDLPEKLLPRISSRMGIQRLCFGPYNYRQLQEIITSRLKGIDAFEDQAIEFASRKVAAMSGDARRALEICRRAAEFADYRVKQSGHTSVNRGKNVVCMGDIEAAIQEVFQAPHIQVMKNCPKFGKIILVAMVHELYRSGLGEVMFDKLAATVLSWCHVNRELLPGYDTLLKICCKLGEGKIILCEEGTKHKLQKLQLNYPSDDVTFALKESPDIPWLSKYL
Protein: Motor neuron and pancreas homeobox 1 (Homeobox protein HB9) (M0R6D8)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor. Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9QZW9}.
Interaction partners:
- Regulatory factor X, 6
- Insulin gene enhancer protein ISL-1
- LIM/homeobox protein Lhx3
Sequence:
MEKSKNFRIDALLAVDPPRAASTQSAPLALVTSLAATPSGPGRGGSGGGGTSSGASRSCSPASSEATAAPGDRLRAESPSPPRLLTAHCALLPKPGFLGAGGGGGAAGGPGTPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYSYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGAGTFQLDQWLRASTAGMILPKMPDFSSQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGSGGGAGKGGTEEKTEEELLGPPVSGDKASGRRLRDLRDSDPDEDEDDEEDHFPYSNGVGAHAASSDCSSEDDSPPPRPGGPGHQPLPQ
Protein: Paired box 6b (Paired box protein Pax-6b) (Pax-family transcription factor 6.2) (Q9YHZ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MPQKEYHNQPTWESGVASMMQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVGKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQSGTWGTRPGWYPGTSVPGQPNQDGCQQQDNGGENTNSISSNGEDSDETQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNSSSHIPISSSFNTSVYQAIPQPTTPVSFTTGSMLGRPDTALTNTYTGLPPMPSFTMANNLPMQPSQTSSYSCMLPSSPSVNGRSFDTYTPPHMQAHMNSQTMATSGTASTGLISPGVSVPVQVPGTEPDMSQYWSRLQ
Protein: Photosystem I assembly protein Ycf3 (P61843)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential for the assembly of the photosystem I (PSI) complex. May act as a chaperone-like factor to guide the assembly of the PSI subunits.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00439}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00439}.
Interaction partners:
- Photosystem I P700 chlorophyll a apoprotein A1
- Photosystem I P700 chlorophyll a apoprotein A2
- NAD
- Photosystem I iron-sulfur center
- Photosystem I reaction center subunit III, chloroplastic
- Cytochrome b6-f complex subunit 4
- ATP synthase subunit b, chloroplastic
- Photosystem I assembly protein Ycf4
- Chloroplastic ATP-dependent Clp protease proteolytic subunit 1
- DNA-directed RNA polymerase subunit beta''
Sequence:
MPRSRINGNFIDKTFTIVADILLRVIPTTSGEKEAFTYYRDGMSAQSEGNYAEALQNYYEAMRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFRALERNPFLPQAFNNMAVICHYRGEQAIQQGDSEMAEAWFAQAAEYWKQAITLTPGNYIEAQNWLTITRRFE
Protein: DOMON domain-containing protein FRRS1L (Brain protein CG-6) (Ferric-chelate reductase 1-like protein) (Q9P0K9)
Organism: Homo sapiens (Human)
Function: Important modulator of glutamate signaling pathway.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:B1AXV0}. Synapse {ECO:0000250|UniProtKB:B1AXV0}.
Interaction partners:
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein mL46
- Protein Abitram
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein uL22m
- Small ribosomal subunit protein uS15m
Sequence:
MARPPRQHPGVWASLLLLLLTGPAACAASPADDGAGPGGRGPRGRARGDTGADEAVPRHDSSYGTFAGEFYDLRYLSEEGYPFPTAPPVDPFAKIKVDDCGKTKGCFRYGKPGCNAETCDYFLSYRMIGADVEFELSADTDGWVAVGFSSDKKMGGDDVMACVHDDNGRVRIQHFYNVGQWAKEIQRNPARDEEGVFENNRVTCRFKRPVNVPRDETIVDLHLSWYYLFAWGPAIQGSITRHDIDSPPASERVVSIYKYEDIFMPSAAYQTFSSPFCLLLIVALTFYLLMGTP
Protein: Phosphodiesterase (EC 3.1.4.-) (A0A8I6AT14)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGCAPSIHVSQSGVIYCRDSDESNSPRQTSSVSQGPTAPLHGLFVQTDAADAMPPSRAAGPPGAVRVRRSRAELGSGSSTGSSGPAATTCRGRRRHCCSSAEAETQTSYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTRNFDAEAVCRSIRATNPSEHTVILAVVSQASDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDSSKQIHRIHRDSGDNSQTEPHSFRHKSRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKDGLRRLSGNEYVFTKNVHHSHSHLSMPITINDVPPSIAQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAAESEGSDCECNPTGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSNS
Protein: Ecdysone dependent glycoprotein (Q9U9P3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
IPCANIVLTYFNDIYDHVSKHLTTDAVCHVSGVCASRYHQHEEEKQPQEALVALDAGDDIPCELCEQLVKHLRDVLVANTTETEFKQVMEGFCKQSKGFKDECLSIVDQYYHVIYETLVSKLDANGACCMIGICQKNSASSMKDVPIMPLLPVIEPAQVKITIEKLEKHEKKQLGASEPKFSQQEILDMQLPIDHLMGAANPGALVEGGELCTLCEYMLHFIQETLATPSTDDEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMCPKNLPKKEDVEVFNPQPASDEQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVNTYSNELIDMLITDFKPQEICVQLKLCPKTTYALWDLRISLEDDVDGEHKSSSEEISFNDIESLEELPPQLPSTQDSPLLRTA
Protein: 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase (EC 3.7.1.21) (6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase) (Beta-oxoacyl-CoA hydrolase) (Oah) (O87872)
Organism: Thauera aromatica
Function: Involved in the central benzoyl-CoA catabolism. Catalyzes the addition of one molecule of water to the double bond and the hydrolytic cleavage of C-C bond in the alicyclic ring, 6-oxocyclohex-1-ene-1-carbonyl-CoA (6-OCH-CoA) to yield 3-hydroxypimelyl-CoA.
Interaction partners:
Sequence:
MNPTTQKLVEQNAPAQLVDHNLVPETVCPGVLYEKRPARNLKGEVVPGLYNVWISLDNPKQYNSYTTDMVKGLILAFRAASCARDVASVVFTAVGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSAILGCDKPVICRVNGMRIGGGQEIGMAADFTVAQDLANFGQAGPKHGSAAIGGATDFLPLMIGCEQAMVSGTLCEPFSAHKANRLGICMQIVPALKVDGKFIANPLVVTDRYLDEFGRIIHGEFKTGDELAAGKELMKRGEIDLSLLDEAVEKLCAKLISTFPECLTKSFEELRKPKLDAWNRNKENSRAWLALNMMNEARTGFRAFNEGNKETGREIEFTDLRQALAKGMPWTPELIESLMPGAK
Protein: Phosphoglucomutase 1 (PGM) (EC 5.4.2.2) (Glucose phosphomutase) (Q9VUY9)
Organism: Drosophila melanogaster (Fruit fly)
Function: This enzyme participates in both the breakdown and synthesis of glucose.
Interaction partners:
- Glycogen phosphorylase
- Glucose-6-phosphate isomerase
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogen debranching enzyme
- glucose-6-phosphate 1-epimerase
- 1,4-alpha-glucan branching enzyme
- transketolase
- ribose-5-phosphate isomerase
- Probable transaldolase
- Hexokinase type 1
Sequence:
MSLTVEIVATKPYEGQKPGTSGLRKKVKVFTQPNYTENFVQAILEANGAALAGSTLVVGGDGRFYCKEAAELIVRLSAANGVSKLLVGQNGILSTPAVSSLIRHNKALGGIVLTASHNPGGPENDFGIKFNCENGGPAPDAFTNHIYKITTEIKEYKLVRNLQIDISKVGVTSFDIAGKPFTVEVIDSVANYVRHMEEIFDFAKLKDFVSGKATGKPLKMRIDAMNGVTGSYVREIFLNRLGATESSVVHTTPLPDFGGLHPDPNLTYAKDLVDTVAQGDYDIGAAFDGDGDRNMIIGSKAFFVTPSDSLAVIAHYLEAIPYFQKNGVQGFARSMPTASAVDLVGRKLGKEVFEVPTGWKYFGNLMDAGRLCLCGEESFGTGSNHIREKDGIWAVLAWISVMQHTGKGIEDILKQHWSVYGRNYFTRYDYEECASDPCNEMVATMEKTITAPEFVGKSYSSGGKTYKVKEADNFSYTDPVDKSVATKQGLRIVFEDGSRIVVRLSGTGSSGATVRLYIDSYEKENVLGQASVMLKPLIDIALEISQLPKFTGRNAPTVIT
Protein: Mycothione reductase (EC 1.8.1.15) (Mycothiol-disulfide reductase) (NADPH-dependent mycothione reductase) (P9WHH3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol.
Interaction partners:
- Multifunctional 2-oxoglutarate metabolism enzyme
- 3-methyl-2-oxobutanoate dehydrogenase subunit beta
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoyllysine-residue acyltransferase component of branched-chain alpha-ketoacid dehydrogenase complex
- Serine aminopeptidase S33 domain-containing protein
- Putative glutaredoxin Rv3198A
- Uncharacterized protein Rv1734c
- Probable dehydrogenase
- 3-methyl-2-oxobutanoate dehydrogenase subunit alpha
- Mycothiol S-conjugate amidase
Sequence:
METYDIAIIGTGSGNSILDERYASKRAAICEQGTFGGTCLNVGCIPTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALSGEDYRRCAPNIDVYRTHTRFGPVQADGRYLLRTDAGEEFTAEQVVIAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIVGSGFIAAEFAHVFSALGVRVTLVIRGSCLLRHCDDTICERFTRIASTKWELRTHRNVVDGQQRGSGVALRLDDGCTINADLLLVATGRVSNADLLDAEQAGVDVEDGRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVVQHNLLCDWEDTQSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAYGWAMEDTSGIVKLITERGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAAEMARGQYWIHPALPEVVENALLGLR
Protein: Glyceraldehyde-3-phosphate dehydrogenase 2 (GAPDH) (EC 1.2.1.59) (NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase) (O34425)
Organism: Bacillus subtilis (strain 168)
Function: Involved in the gluconeogenesis. Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NADP. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NADP to NADPH. The reduced NADPH is then exchanged with the second NADP, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Probable fructose-bisphosphate aldolase
- Enolase
- Phosphoenolpyruvate carboxykinase
- Glucose-6-phosphate isomerase
- Pyruvate kinase
- Glucose-6-phosphate 1-dehydrogenase
- Transketolase
- L-lactate dehydrogenase
Sequence:
MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHLIKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNAKDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPVVKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSLVLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYSDEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARMKHPSAV
Protein: Uncharacterized protein (Q580T0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSDYGDSFDSSASSSTTTPSSSLTSASSSQQESEKATSDTKELTSVVSPLAALPVPLPLPVPVAAPVPAPVLSPQPASGVSSEVTAADAPTLKPTDNLPTPDIAAAPREAVDSQEPPMRSPRNSTASKTLVNTSDSAYEAPGGDLAAADTVAYKRLTSYVAFNQSSDGSVAAECANTSSFSGKREASADDDTKVPKMDEPTGPVATLEENSETATAAGVEESSTVDGSSAFSTLSQHLSKTVTHAKLCAEMASVTKGPSDEVRTGGDGVMHPSGDGGGPMITANVPAAATTMLKPLMSLPPLPSAAESMTLKADFPLPSTSPSPDGLIPERIAFAAQSIQSMPIPPPLPPAPLSGIKSGMMPSLDNAPASSFYLPPPPLAQSREPPVNNKIVELRETSEAVEKLVRAFALLRGHNPTGSRGAAADISEVSFAPNELARMSSLRQEHGVGDSATIKTSQTHRRRPLRSGMPKTHVEESDENQKASQQINEAAVEEAVLSLVMEMMQQDPQQMSKASSSRRFLQPACELIGMDDFRYSHHRSSKRQRGPRPQAAPLSVFGGGMQAFAPDDDGAAESLYNSVIEALGKYVWSHVEESSLRGERPTFPPVSAHCAIALQLDLLSVCLQVIETRLTHRGNVADGPVWIQYDGPRESEPLARNAAHCLPFESIDVKTSRRPVFRLEYWVTRENMWAVAEALVSSVRGGILDGGDGYGVFNAKSTTYVDPDTLFPTRVPYFSLLPGDSSRPPREECSPSPGKKFFTNTRRSDKDSEDEATDKPCAEHFHLEPPALQAIAHAVSTVGTEILEENINAARGDYKQNYGDATCAVVEAVRELLEDANIRAAVRRRAKAKMKDIAQRREVEGQLSREEKERSIIAAAEAEAEQVVQRILQELRVEEARNV
Protein: MYB proto-oncogene, transcription factor (A0A0G2K2A4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Histone lysine acetyltransferase CREBBP
- CCAAT/enhancer-binding protein beta
- Lin-9 DREAM MuvB core complex component
- Protein lin-52 homolog
- Lin-37 DREAM MuvB core complex component
- Histone-lysine N-methyltransferase
Sequence:
MARRPRHSIYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEDEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQEPSKASQTPVVSSFQKNNHLMGFAHASPPPTSQSSVNGEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQALPTQNHTCSYPGWHSTSIVDQTRPHGDSAPVSCLGENHATPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSDSSRCDLSSFEFSEEAAAFSPSQQHTGKTFQLQEREGHGTRSAGEPSLRVTRRVLSEASLRQAKASPLVFLRKRRGQASPTAAGDSSSSLFADVSSSTPKRSPVKSLPFSPSQFLNTSSNHENSGLDTPTLPSTPLIGHKLTPCHRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHVVEDLQDVIKQESDESGIVAEFHENGPPLLKKIKQEVDSPTEKAGNFFCSNHWEETNLSTQLFAQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPCVGAWEPTPSCGKTEDQMTASGQARKYVNTFSARTLVM
Protein: Trichohyalin, putative (Q383D0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein kinase, putative
- DNA replication licensing factor MCM4
- Uncharacterized protein
- Cell division cycle 45
- DNA replication licensing factor MCM2
- DNA helicase
- non-specific serine/threonine protein kinase
- Phosphatidylinositol 3-kinase catalytic subunit, putative
- DNA 3'-5' helicase
Sequence:
MPDSEGAASIHDERPSEVPEGGSPLGEAAITSTANGHSKVKRRRILQREIDKFRQQSIENAKQTVSRIKASEVEVKRRREQDAETRAKRAEDVKKSLEEERLFLQKVREREEQRKVAQVKLLRTSTPPREEVRRRIEEDRRKNRERVQAESEKLLAAAREEEERRMEMILKRKQEEEEAPRKQRNAELERKAKELENLKKSLERDRQAIRKAREEEERRKAREVRILRRIEKDWCAEAVKESLEHRRKIKERVQAESEKLLAAAREEEERRMEMILKRKQGEEDGPRRVQESELEKQRKAKELENLKKSLEEERLFLRKMREEEEQRKVAQVKLLRTSTPPREEVRRRIEEDRRKNRERVQAESEKLLAAAREEEERRRKMILQKKQGEEEAPRKQRNAELERKAKELENLKKSLERDRQAIRKAREEEEQRKVAQVKLLRTSTPPREEVRRRIEEDRRKNRERVQAESEKLLAAAREAEERRMEMILKRKQGEEDGPRRVQESELEKQRKAKELENLKRRLEKDRLALQKIRKEDDSVDETALAENGIVELLEVAHAVVEEGEKVLLQRKHTTREASTPRRMEVEKKKAKAVEDIKKALEEERLARQKEREQEVQRKAEQVRLLREKMKQRREDLLRAQEEKRKKAAEGIWEFVPVS
Protein: T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Chaperonin CCT3) (Q84WV1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit beta
- TCP-1/cpn60 chaperonin family protein
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit zeta 2
- T-complex protein 1 subunit zeta 1
- ATP binding protein
Sequence:
MHAPVLVLSDSLKRESGSKVHHGNIQASKAVADIIRTTLGPRSMLKMLLDAGGGIVVTNDGNAILRELDVAHPAAKSMIELSRTQDEEVGDGTTSVIVLAGEMLHVAEAFLEKNYHPTVICRAYIKALEDSIAVLDKIAMSIDINDRSQVLGLVKSCIGTKFTSQFGDLIADLAIDATTTVGVDLGQGLREVDIKKYIKVEKVPGGQFEDSEVLKGVMFNKDVVAPGKMKRKIVNPRIILLDCPLEYKKGENQTNAELVREEDWEVLLKLEEEYIENICVQILKFKPDLVITEKGLSDLACHYFSKAGVSAIRRLRKTDNNRIAKACGAVIVNRPDELQESDIGTGAGLFEVKKIGDDFFSFIVDCKEPKACTVLLRGPSKDFINEVERNLQDAMSVARNIIKNPKLVPGGGATELTVSATLKQKSATIEGIEKWPYEAAAIAFEAIPRTLAQNCGVNVIRTMTALQGKHANGENAWTGIDGNTGAIADMKESKIWDSYNVKAQTFKTAIEAACMLLRIDDIVSGIKKKQAPGSGPSKPTIETEGDADNEQILPD
Protein: Ribonuclease H1 (RNase H1) (EC 3.1.26.4) (O44114)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLLPRYFCWNLQRCTMAFYAVASGRRSGVYGSWAECEEQVKGFKNAKYKKFKTRQEADQFVNGCKSYAPQDVAVPLGKEKASLASWKNSIEVNKNPKYTDEWPEEDHDLAEDDLNAAMNEVEGDPKPSNSSNLPDILNRKRKGTTSGDKRNKIPRHASQVSEATGLKQVGAFQFEIDAEGYVIVYTDGSCIGNGRTGACAGYGVYFGKNHQLNAAKPVEGRVTNNVGEIQAAIHAIKTALDLGIQKLCISTDSQFLINSITLWVAGWKKRDWKLKNNQPVKNVVDFKELDKLLQDNNITVKWNYVEAHKGIEGNEMADKLARQGSALYKQKNG
Protein: Calcineurin-like phosphoesterase domain-containing protein (Q55D82)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MKSILFKIFTFIVINFIYPIFSNNLKVETININIDRLQNKDDNDQINKNKKQQKPIKIIQLSDIHYDKIPLRITDKFLEKIVKTTNDLKPDLILITGDLIERDPIPISQLYNKHLSKLKSKYGVYSILGNHDYKNSTSPEIIKNALKNTNINLLENEIVYPMGKENDDGSGGIQLIGFDNYAKRDKKQMDELNNEIKSSSNENLIKLALVHNPDHVIQMLLKDNDLNMDIALCGHSHGSQICFPSFNFLGFKIGSGGPVMPHFESLLQKIPFKFIRDIKYPGKKTLKYWQYGKGYHKIMNNDNLLIGAHNSNNSNNNNNNITKLNLYVNRGLGTHPPVRLFCDPEITVINIYQ
Protein: B-cell receptor-associated protein (BCR-associated protein) (A0A0G2JXK2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367026}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367026}.
Interaction partners:
Sequence:
MQGGLLASGETFLVLELSPRNKLLSICWKPLSHRMSLQWTAVATFLYAEVFAVLLLCIPFISPKRWQKIFKSRLVELVVTYGNTFFVVLIVILVLLVIDAVREIRKYDDVTEKVNLQNNPGAMEHFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKGTAEDGGKLDVGSPEMKLEENKILKTDLKKLKDELASTKKKLEKAENEALAMQKQSEGLTKEYDRLLEEHAKLQASVRGPSDKKEE
Protein: Transmembrane protein 196 (Q5HYL7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36355209}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed in the cytoplasm in lung cancer cells. {ECO:0000269|PubMed:36355209}.
Interaction partners:
Sequence:
MCTSGQIIGSLLVLSVLEIGLGVSSVAVGAVSFSLALREHKPQLGDSSPVWSGVCFLLCGICGILCAKKKSGLVMILFSACCICGLIGGILNFQFLRAVTKKTSSLYPLHLASMSLACIGIGGCTLSSWLTCRLASYEQRRMFSEREHSLHHSHEMAEKEITDNMSNGGPQLIFNGRV
Protein: Flocculation protein FLO1 (Flocculin-1) (P32768)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. Also involved in cell-substrate adhesion.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Identified as GPI-anchored plasma membrane protein (GPI-PMP) as well as covalently-linked GPI-modified cell wall protein (GPI-CWP) in the outer cell wall layer.
Interaction partners:
- Transcription activator MSS11
- Flocculation protein FLO11
- Flocculation suppression protein
- Ty transcription activator TEC1
- Protein MSN1
- Protein STE12
- Putative transcription factor PHD1
- Morphogenetic regulator of filamentous growth protein 1
- cAMP-dependent protein kinase type 2
- FACT complex subunit SPT16
Sequence:
MTMPHRYMFLAVFTLLALTSVASGATEACLPAGQRKSGMNINFYQYSLKDSSTYSNAAYMAYGYASKTKLGSVGGQTDISIDYNIPCVSSSGTFPCPQEDSYGNWGCKGMGACSNSQGIAYWSTDLFGFYTTPTNVTLEMTGYFLPPQTGSYTFKFATVDDSAILSVGGATAFNCCAQQQPPITSTNFTIDGIKPWGGSLPPNIEGTVYMYAGYYYPMKVVYSNAVSWGTLPISVTLPDGTTVSDDFEGYVYSFDDDLSQSNCTVPDPSNYAVSTTTTTTEPWTGTFTSTSTEMTTVTGTNGVPTDETVIVIRTPTTASTIITTTEPWNSTFTSTSTELTTVTGTNGVRTDETIIVIRTPTTATTAITTTEPWNSTFTSTSTELTTVTGTNGLPTDETIIVIRTPTTATTAMTTTQPWNDTFTSTSTELTTVTGTNGLPTDETIIVIRTPTTATTAMTTTQPWNDTFTSTSTELTTVTGTNGLPTDETIIVIRTPTTATTAMTTTQPWNDTFTSTSTEITTVTGTNGLPTDETIIVIRTPTTATTAMTTPQPWNDTFTSTSTEMTTVTGTNGLPTDETIIVIRTPTTATTAITTTEPWNSTFTSTSTEMTTVTGTNGLPTDETIIVIRTPTTATTAITTTQPWNDTFTSTSTEMTTVTGTNGLPTDETIIVIRTPTTATTAMTTTQPWNDTFTSTSTEITTVTGTTGLPTDETIIVIRTPTTATTAMTTTQPWNDTFTSTSTEMTTVTGTNGVPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLVTTTTEPWTGTFTSTSTEMTTITGTNGVPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEMTTITGTNGQPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEMTHVTGTNGVPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLVTTTTEPWTGTFTSTSTEMSTVTGTNGLPTDETVIVVKTPTTAISSSLSSSSSGQITSSITSSRPIITPFYPSNGTSVISSSVISSSVTSSLFTSSPVISSSVISSSTTTSTSIFSESSKSSVIPTSSSTSGSSESETSSAGSVSSSSFISSESSKSPTYSSSSLPLVTSATTSQETASSLPPATTTKTSEQTTLVTVTSCESHVCTESISPAIVSTATVTVSGVTTEYTTWCPISTTETTKQTKGTTEQTTETTKQTTVVTISSCESDVCSKTASPAIVSTSTATINGVTTEYTTWCPISTTESRQQTTLVTVTSCESGVCSETASPAIVSTATATVNDVVTVYPTWRPQTANEESVSSKMNSATGETTTNTLAAETTTNTVAAETITNTGAAETKTVVTSSLSRSNHAETQTASATDVIGHSSSVVSVSETGNTKSLTSSGLSTMSQQPRSTPASSMVGYSTASLEISTYAGSANSLLAGSGLSVFIASLLLAII
Protein: Antitoxin RelJ (Antitoxin YefM) (P9WF25)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. A probable antitoxin for the putative mRNA interferase RelK. Upon expression in E.coli but not in M.smegmatis this protein neutralizes E.coli YoeB.
Interaction partners:
- Toxin RelK
- Toxin RelE
- Antitoxin RelB
- Antitoxin RelF
- Toxin RelG
Sequence:
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSVDELREMAGGEE
Protein: Homeobox protein ceh-60 (Q45EK2)
Organism: Caenorhabditis elegans
Function: Probable transcription regulator which binds to DNA, repressing genes involved in longevity and stress, while activating genes involved in reproduction, such as the vitellogenins. Associates with homeobox unc-62 to regulate gene expression, including repression of genes involved in innate immunity. Required for intestinal expression of vitellogenin genes. Negatively modulates longevity, probably independently of effects on vitellogenesis. Involved in lipid homeostasis, contributing to the reallocation of intestinal lipids to the germline and to the formation of the cuticle. Associates with transcriptional regulator pqm-1 at the daf-16 associated element within the promoters of stress-responsive genes to regulate expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:30956009}. Note=Localizes to the nucleus in an unc-62-dependent manner. {ECO:0000269|PubMed:30956009}.
Interaction partners:
- Homeobox protein unc-62
- Vitellogenin Regulating Protein
- Homeobox protein php-3
- Zinc finger transcription factor pqm-1
- Homeobox protein nob-1
Sequence:
MDNLIKQLQMSVSSENVDRNFIEKCIEMNPCRRMLHEVLLERKDILRSRMNLVALYDTDEQSSEIEEILAQFENPTFPLEEVNTEKDEEWQPLERKYLDGINRIKEDTIMKQIQLDKDMEKALTNSEEVLRNHRDFRPIDEKDFSNIRQSISKRFEHSKNNIRGEAATKILVLRREIEQQGRKRRNFDKNTTDILQNWFHDHRQNPYPSDQEKAELAKQCNIKISQVNNWFGNQRIRTKQQALRMQEDERERAASMANEAQAIQNSLNSSTVASSSNMSTSGLINIPLVNPTMQSMVIPAVQPGLLGNPNAFLHQPHYFTAGGQMSLNDNGNGQQFFTDYETFGLAQSDTESFNQMGYLG