wanglab/gogpt-training-data huggingface dataset:
Protein: Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (P04046)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Phosphoribosylformylglycinamidine synthase
- Bifunctional purine biosynthetic protein ADE5,7
- Phosphoribosylglycinamide formyltransferase
- Adenylosuccinate lyase
- Bifunctional purine biosynthesis protein ADE17
- Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Phosphoribosylaminoimidazole carboxylase
- Multifunctional protein URA2
- Glutamine synthetase
- Bifunctional purine biosynthesis protein ADE16
Sequence:
MCGILGIVLANQTTPVAPELCDGCIFLQHRGQDAAGIATCGSRGRIYQCKGNGMARDVFTQQRVSGLAGSMGIAHLRYPTAGSSANSEAQPFYVNSPYGINLAHNGNLVNTASLKRYMDEDVHRHINTDSDSELLLNIFAAELEKHNKYRVNNEDVFHALEGVYRLCRGGYACVGLLAGFALFGFRDPNGIRPLLFGERENPDGTKDYMLASESVVFKAHNFTKYRDLKPGEAVIIPKNCSKGEPEFKQVVPINSYRPDLFEYVYFARPDSVLDGISVYHTRLAMGSKLAENILKQLKPEDIDVVIPVPDTARTCALECANVLGKPYREGFVKNRYVGRTFIMPNQRERVSSVRRKLNPMESEFKGKKVLIVDDSIVRGTTSKEIVNMAKESGATKVYFASAAPAIRYNHIYGIDLTDTKNLIAYNRTDEEVAEVIGCERVIYQSLEDLIDCCKTDKITKFEDGVFTGNYVTGVEDGYIQELEEKRESIANNSSDMKAEVDIGLYNCADY
Protein: Photosystem II reaction center protein H (PSII-H) (Photosystem II 10 kDa phosphoprotein) (P0C421)
Organism: Oryza sativa subsp. indica (Rice)
Function: One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00752}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00752}.
Interaction partners:
- Photosystem II D2 protein
- Photosystem II CP43 reaction center protein
- Photosystem II CP47 reaction center protein
- Photosystem II protein D1
- Cytochrome b559 subunit alpha
- Cytochrome b559 subunit beta
- Photosystem II reaction center protein K
- Photosystem II reaction center protein L
- Photosystem II reaction center protein I
- Photosystem II reaction center protein Z
Sequence:
MATQTVEDSSRPGPRQTRVGNLLKPLNSEYGKVAPGWGTTPFMGVAMALFAVFLSIILEIYNSSVLLDGILMN
Protein: Arginine N-methyltransferase 2 (EC 2.1.1.-) (A0A1D8PMZ3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR038148}. Nucleus {ECO:0000256|PIRNR:PIRNR038148}.
Interaction partners:
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Rpl7p
- SnoRNA-binding rRNA-processing protein
- Nucleolar GTP-binding protein 1
- Csi2p
- Protein-arginine omega-N methyltransferase
- Ribosome production factor 2 homolog
- GTPase
- mRNA-binding ribosome synthesis protein
- Alpha N-terminal protein methyltransferase 1
Sequence:
MSELHDLCKFPTRPIDQSYIDKLTQYLKDGIPATYTIEEAYNYINNIEEEPTTTTTPLHLICSHAPFDITKEEQEIISTMVEKLFEYGAGWSFTDINNQTPGCILISRRKERENKEEDGKWMNDVYQQIIDAGVRAELLLRKVNEFEEIEFIEEDDEQEEKEEEDIPQLVKDEQEIKEEAKQEQTTTTDIKPVVIDDAPDAPSQNQQSYLNTKLEYINDALITKDDKDGVMMAWENDIMKLASDTITSSASSASDSESEQEVNILNIGFGMGIIDAMIQSKLKSHPNAKHYICEAHPDVLQKMKIDGWYEKPNVIILEGRWQDKLNDLLSSSSSSSEASVFFDGIYYDTFSEHYQDMLELFDIIVGLLKPHGIFSFFNGLGADRQIIYEVYKNLLIIDLENYGLNCQFKEFNVPNEKFWNKLQDKSIWDDVKRSYWSCPIYYHPIIKFIDY
Protein: Putative uridine kinase C227.14 (EC 2.7.1.48) (Q9UTC5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein mL61
- Vacuolar amino acid transporter 3
- Pantoate--beta-alanine ligase
- Synaptobrevin homolog ykt6
- Autophagy-related protein 18
- Uncharacterized protein C4B3.18
- Probable thymidylate synthase
- 1-phosphatidylinositol 3-phosphate 5-kinase fab1
- Putative cytidine deaminase
Sequence:
MALQVDAPDVSSYDELYNRAVELLKHQQRVLIGLAGGPGSGKSTLCAILAKAWNERFGSEIVKIIPMDGFHYSLEELDRFDNPEKARALRGAEWTFDADLFYSLVRLMKKITDRELYAPSFDHAIGDPVVDDICVEPKNRILIFEGNYLLLNKPPWSDACKLYDIKAYLPVEHSVARARVAHRHLVSGLCATEEEAIERTDRNDMINLTFVEKNMVTPDIVLQQLRLKTVKTSSL
Protein: Protein Tob2 (Protein Tob4) (Transducer of erbB-2 2) (Q14106)
Organism: Homo sapiens (Human)
Function: Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
Subcellular location: Cytoplasm.
Interaction partners:
- CCR4-NOT transcription complex subunit 7
- Polyadenylate-binding protein 1
- RIB43A-like with coiled-coils protein 1
- CCR4-NOT transcription complex subunit 8
- Nanos homolog 2
- CCR4-NOT transcription complex subunit 6-like
Sequence:
MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHWYPEKPLKGSGFRCVHIGEMVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQIGEKGAVKVLYLDDSEGCGAPELDKEIKSSFNPDAQVFVPIGSQDSSLSNSPSPSFGQSPSPTFIPRSAQPITFTTASFAATKFGSTKMKKGGGAASGGGVASSGAGGQQPPQQPRMARSPTNSLLKHKSLSLSMHSLNFITANPAPQSQLSPNAKEFVYNGGGSPSLFFDAADGQGSGTPGPFGGSGAGTCNSSSFDMAQVFGGGANSLFLEKTPFVEGLSYNLNTMQYPSQQFQPVVLAN
Protein: Endoplasmic reticulum membrane protein 65 (65 kDa endoplasmic reticulum membrane protein) (P40085)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in membrane protein folding.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23275891}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:14576278}.
Interaction partners:
- Uncharacterized protein SLP1
Sequence:
MQHKDTAVAKDTAKKRLLRRNSAPSAIHIISRLDKKWSFLWNTIDRHNIVEEQDESSAAKSEEEHEDDYELEQLLNMIRIPMFLEKFMLFALLTSLDCFLYYFTVLPIRLIKGYVKQFKSYRQHYRLQQRSGHKNKIPFRYRITSREYKERCMIFIIVISSILLSKLDTSKLYHRIKRQSTMKLYMLFSVLEMADKMLASLGQSLLTVMLSRKNSERILLHKCLLVSMSLTYVTIHGYVLVYQAISLNIAVNSYSNALLTLLLSMQFAEIKSSVLKKFDKEGFFQITIADVVERFKLTLLLSITGLRNLQSWSSSLSNTSINFWSPRSTLSIVINILCGPMVSVVGSEVLVDWAKHAYITKFNRIRPQIYDKFYYIIYKDYSTRTHKLEDRLGLPLPAFVVLFIVMVRPTLFKSSEPSYLPSLFRILFMGASVFLLALLAKFTLDLILIKWSKRIEQRFRDQAFNTVVTEEEYVPGLLSGGMGKVDVSTRIALHSDYNKENRIETESVSPMRKRKTTLTAECTPPSLNDIRRQKDSKNPRSLENVARYKMVSKRIW
Protein: Cytochrome P450, family 89, subfamily A, polypeptide 5 (Putative cytochrome P450) (Q9XIQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- FAD/NAD
- PIF1 helicase
- PIF1 helicase
- PIF1 helicase
- Protein TIFY 4A
- DEAD-box ATP-dependent RNA helicase 8
Sequence:
MEIWLLILGSLFLSLLLNLLFFRLRDSSSLPLPPDPNYFPFIGTIQWLRQGLGGLNNYLRSVHHRLGPIITLRITSRPSIFVADRSLAHQALVLNGAVFADRPPAAPISKIISSNQHNISSCLYGATWRLLRRNLTSEILHPSRVRSYSHARRWVLEILFDRFGKNRGEEPIVVVDHLHYAMFALLVLMCFGDKLDEKQIKQVEYVQRRQLLGFSRFNILNLWPKFTKLILRKRWEEFFQMRREQHDVLLPLIRARRKIVEERKNRSSEEEEDNKEYVQSYVDTLLELELPDEKRKLNEDEIVSLCSEFLNGGTDTTATALQWIMANLVKNPDIQKRLYEEIKSVVGEEANEVEEEDAQKMPYLEAVVMEGLRRHPPGHFVLPHSVTEDTVLGGYKVPKNGTINFMVAEIGRDPKVWEEPMAFKPERFMEEAVDITGSRGIKMMPFGAGRRICPGIGLAMLHLEYYVANMVREFDWKEVQGHEVDLTEKLEFTVVMKHPLKALAVPRRSH
Protein: Iron-phytosiderophore transporter (Q2PGC4)
Organism: Hordeum vulgare (Barley)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDIVAPDRTRIAPEIDRDEALEGDRESDPALASTREWQLEDMPRWQDELTVRGLVAALLIGFIYTVIVMKIALTTGLVPTLNVSAALLSFLALRGWTRLLERFGVVSRPFTRQENTIVQTCGVACYTIAFAGGFGSTLLGLNKKTYELAGDSPGNVPGSWKEPGIGWMTGFLLACSFGGLLTLIPLRQVLVVDYKLVYPSGTATAILINGFHTDQGDKNSRKQIRGFLKYFGGSFLWSFFQWFYTGGDACGFVQFPTFGLKAWKQTFYFDFSMTYVGAGMICPHIVNISTLLGAIISWGIMWPLISKNKGDWYPAKVPESSMKSLYGYKAFICIALIMGDGMYHFIKIVGITAMSMYRQFSHKQVNNKAKNADDTVSLEELHRQEIFKRGHIPSWMAYAGYALFSVLAVVTIPVMFKQVKWYYVVIAYVVAPMLGFANSYGTGLTDINMGYNYGKIALFVFAGWAGKENGVIAGLVAGTLVKQLVLISADLMQDFKTSYLTQTSPKSMMIAQVVGTAMGCIVSPLTFMLFYKAFDIGNPDGTWKAPYALIYRNMAILGVEGFSVLPKYCIVISGGFFAFAAILSITRDVMPHKYAKYVPLPMAMAVPFLVGGSFAIDMCLGSLIVFAWTKINKKEAGFMVPAVASALICGDGIWTFPASILALAKIKPPICMKFLPAA
Protein: Autophagy-related protein 9 (O74312)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (By similarity). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through atg2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking (By similarity). Has a role in meiosis and sporulation.
Subcellular location: Preautophagosomal structure membrane {ECO:0000269|PubMed:23950735}; Multi-pass membrane protein {ECO:0000269|PubMed:23950735}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q12142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12142}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q12142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12142}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q12142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12142}.
Interaction partners:
- Serine/threonine-protein kinase atg1
- Autophagy-related protein 2
- Autophagy-related protein 18
- Autophagy-related protein 17
- Autophagy protein 13
- Taz1-interacting factor 1
- Autophagy-related protein 8
- Vacuolar protein sorting-associated protein atg6
- Ubiquitin-like protein ATG12
- Ubiquitin-like modifier-activating enzyme atg7
Sequence:
MFYQPAQNKKQYDDLADIEAQNNVPNTQEVLEAWQESLDSDEDESSPLEESNGFTISEHDDFVKSVPRKNNPTDLLYSGKLLDSDEPPSVHGNSSKVPSKHPSPSFPETTSLRNLQNGSKQKPALPNFNDPHFYNEDVTRSGHPNRSIYTQLPRNEFSNARVLWNRLSARDRVLWRWANVENLDSFLQQVYTYYTGKGLSCIIVHRLFQILTVSFVIGFTTFITSCIDWPAVTPHGSLAGVTKSQCIAQMSPITYLVLWLFLSFLLALWIYYLTDIPRLWQMREFYIHALKIATADMPTVSWQRVLYRLLKLKNVNALTAEDGRVVSLHNMKRLDAYAIANRIMRKDNYFIALINNGIINIELPLLHRRILTHTTEWNINWCIFNFVFDEQGQLRSAFRNPNSRKRLSEELRRRFIVAGFLNCLFAPIVAIYLVIHNFFRYFNEYHKNPGALSTRRYTPLALWTFREYNELQHFFDERINDSYAAASHYVSQFPDFNMIRLFKYISFILGSFTAILVIITVFDPELMVTFEITKDRSVLFYLGLFGSLIAVSRSIIPDETLVFAPEKALRRVITFTHYMPGWWSDNMHSKAVQQEFCSLYSYRIVNLLWEILGILLTPVLLFFTFPSCSQDIVDFFREHTINVEGVGYVCSYAVFQDNPPYESVASLVQSRKISPLIQNKPELSRISFYEQFNTEAPRRDLR
Protein: RE55660p (Q86P50)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGSFWQQHVATPSSSTPFDSPFFSATHGLVQTHPSIGGSHSGPAPLNGNSLGSGAPSSILAGTKPALTAGSGYLNSRGSLPTSARYPANKITGTVVEPNPKSPFRHLDFSTSATAELRRNPALSAPDECARACREGEPPRICYYHFTLEYYAVLGAACQVCTPNATNTVWSHCQCVLADGVERGILTANRMIPGPSIQVCENDKVVIDVENHMEGMEVTIHWRGIWQRGSQYYDGVPFVTQCPIQQGNTFRYQWTGNAGTHFWHAHTGLQKLDGLYGSVVVRQPPSRDPNSHLYDFDLTTHIMLISDWLHEDAAERYPGRLAVNTGQDPESMLINGKCQFRDPNTGFMTNTPLEIFTITPGRRYRFRMINAFASVCPAQVTIEGHGMTVIATDGEPVHPVDVNTIISFSGERYDFVISADQPVGAYWIQLRGLGECGIRRAQQLAILRYARGPYQPASSPPTYDVGIPQVVVMNPLDAQCNRQRNDAICVSQLKNALEIDRGILAEKPDVKIFLPFRFFVYRAEDLFQPNTYNRFLVAPTGDHVISLIDEISYLSAPAPLTSQYNDINPDQFCNGDNRPADCGPNCMCTHKIDIPLNAIVEVVLVDEVQQPNLSHPFHLHGYGFSVIGIGRSPDSSVKKINLKHALDLDRRGLLHRQYNLPPTKDTIAVPNNGYVVLRFRADNPGFWLFHCHFLFHIVIGMNLILQDGTNADLPPVPPGFPTCGDHTPSIPIN
Protein: Pectinesterase inhibitor 6 (Pectin methylesterase inhibitor 6) (AtPMEI6) (O22244)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pectin methylesterase (PME) inhibitor that targets PME from seeds and modulates PME activity and pectin methylesterification during seed germination. Promotes mucilage release by limiting methylesterification of homogalacturonan in seed coat epidermal cells.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000250|UniProtKB:Q9STY5}.
Interaction partners:
- Peroxidase 36
- Subtilisin-like protease SBT1.7
- Beta-galactosidase 6
- Probable galacturonosyltransferase-like 5
- Transmembrane E3 ubiquitin-protein ligase FLY1
- Transcriptional corepressor LEUNIG_HOMOLOG
- Pectinesterase inhibitor 5
- Pectinesterase inhibitor 2
- Pectinesterase inhibitor 1
- Probable pectinesterase/pectinesterase inhibitor 58
Sequence:
MTSSSSSPITFTLLLLLSLLVALNPNPSLASTGSNINTNDIVTQYSTYVRNACNVTRYNRLCVRTLWPFAIVARNNTSKWARASVAVTITDTKRVLRLLLKTQRSAVGESERIALSDCRELFVDSLDNLYKSLAVLRTLNADEFQRQISDLATWLSAALTDDDTCLDGFEETSSRTRTVRMVRRKATKCMRLCSNALALLKKLAFDGL
Protein: Rhodopsin (P02699)
Organism: Bos taurus (Bovine)
Function: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling.
Subcellular location: Membrane {ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23303210, ECO:0000269|PubMed:27509380, ECO:0000269|PubMed:3350146, ECO:0000269|PubMed:9541408}; Multi-pass membrane protein {ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:27509380, ECO:0000269|PubMed:28655769, ECO:0000269|PubMed:3350146, ECO:0000269|PubMed:9541408}. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia. {ECO:0000250|UniProtKB:P08100}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Rhodopsin kinase GRK1
- Rhodopsin kinase GRK7
- Recoverin
- S-arrestin
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Cone-rod homeobox protein
Sequence:
MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q59DW8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MQRRERQASGGGPQTTTAGPSAGNVANATTALAGGKSSSNNMYSTRQSVSTTTGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHAEGVPEVYYFGPCGKYNALVMELLGPSLEDLFDICGRRFTLKSVLLIAIQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWTGKTMSTPVGSLQTGHEVIISPNKDRHNVTAKTNAKGGVAAWPDVPKPGATLGNLTPADRHGSVQVVSSTNGELNPDDPTAGHSNTPITQQPEVEVVDETKCCCFFKRKKKKSTRQK
Protein: Galactitol 2-dehydrogenase (GDH) (EC 1.1.1.16) (Sorbitol dehydrogenase) (SorbD) (EC 1.1.1.-) (A9CES4)
Organism: Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Function: Involved in galactitol catabolism. Catalyzes the oxidation of galactitol to D-tagatose. Can also catalyze the oxidation of D-sorbitol to D-fructose.
Interaction partners:
- Tagatose kinase
- D-altritol 5-dehydrogenase
- ABC transporter, substrate binding protein
Sequence:
MRLNNKVALITGAARGIGLGFAQAFAAEGAKVIIADIDIARATTSAAAIGPAAKAVKLDVTDLAQIDAVVKAVDEEFGGIDILVNNAAIFDMAPINGITEESYERVFDINLKGPMFMMKAVSNVMIARARGGKIINMASQAGRRGEALVTLYCASKAAIISATQSAALALVKHGINVNAIAPGVVDGEHWEVVDAHFAKWEGLKPGEKKAAVAKSVPIGRFATPDDIKGLAVFLASADSDYILAQTYNVDGGNWMS
Protein: Multidrug resistance protein MdtA (Multidrug transporter MdtA) (Q8ZNQ3)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01422}.
Interaction partners:
- Multidrug resistance protein MdtB
- Multidrug resistance protein MdtC
- Efflux pump membrane transporter
- Putative multidrug resistance protein MdtD
- histidine kinase
- Transcriptional regulatory protein BaeR
- Macrolide export ATP-binding/permease protein MacB
- Efflux pump membrane transporter
- Outer membrane protein TolC
- Periplasmic chaperone Spy
Sequence:
MKGSNTFRWAIAIGVVVAAAAFWFWHSRSESPTAAPGVAAQAPHTASAGRRGMRDGPLAPVQAATATTQAVPRYLSGLGTVTAANTVTVRSRVDGQLIALHFQEGQQVNAGDLLAQIDPSQFKVALAQAQGQLAKDNATLANARRDLARYQQLAKTNLVSRQELDAQQALVNETQGTIKADEANVASAQLQLDWSRITAPVSGRVGLKQVDVGNQISSSDTAGIVVITQTHPIDLIFTLPESDIATVVQAQKAGKALVVEAWDRTNSHKLSEGVLLSLDNQIDPTTGTIKIKARFTNQDDTLFPNQFVNARMLVDTEQNAVVVPAAAVQMGNEGHFVWVLNDENNVSKKRVKIGIQDNRNVVISAGLSAGDRVVTDGIDRLTEGAKVEVVEPQTTVADEKSPSRHEGQKGARA
Protein: Rfx, isoform C (A0A0B4K6P1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTTRLAPQRQFILSTRSAIVDATSPPEDSAEEQQQLTVEVESATNGVITNSTTSPPPHAEQFEFCTEDGVVVSATLEDVMTQNCQLLQKKLVDEDDDSTGVGATDADQLEVISVVLPMDAEDSTSDAHLHGHVVNSSSDTMGTITTTEPNGTTVTHSIPIHSMADLAAIKDGVDLAQQVANGQVTVVQTTEDDDGTPFITVTVSGQEQNYQVQYVDSELYHSNSSQTQMTYPFCPVGDYQGNGQTAYYSTTGQYGTTSSAGGSSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSPHSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDSDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICERMKKDMDFEFECQFAYITSDTEHQTTPSSASSGGDVGNEAKRLKQE
Protein: Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) (GABAAR subunit beta-1) (P18505)
Organism: Homo sapiens (Human)
Function: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P08220}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08220}. Cell membrane {ECO:0000269|PubMed:26950270}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08220}.
Interaction partners:
- Gamma-aminobutyric acid receptor subunit alpha-1
- Gamma-aminobutyric acid receptor subunit beta-3
- Gamma-aminobutyric acid receptor subunit beta-2
- Huntingtin-associated protein 1
- Gamma-aminobutyric acid receptor subunit alpha-4
- Gamma-aminobutyric acid receptor subunit alpha-2
- Vesicle-fusing ATPase
- Trafficking kinesin-binding protein 2
- Inactive phospholipase C-like protein 1
- Gamma-aminobutyric acid receptor subunit gamma-1
Sequence:
MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
Protein: Heat stress transcription factor A-2c (Heat stress transcription factor 25) (OsHsf-25) (Heat stress transcription factor 6) (OsHSF6) (rHsf6) (Q338B0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcriptional activator that specifically binds DNA of heat shock promoter elements (HSE).
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- Os01g0178000 protein.
- Aminotransferase
- Os11g0552000 protein
- Acireductone dioxygenase 4-requiring) 4)
- nicotianamine aminotransferase
- Nicotianamine aminotransferase 1
- Heat shock protein 81-2
- Os04g0107900 protein
- Os06g0274000 protein.
Sequence:
MDPAAAGIVKEEMLESQQQQRQEDGGAAPRPMEGLHEVGPPPFLTKTYDLVEDPATDGVVSWSRAGNSFVVWDPHVFADLLLPRLFKHNNFSSFVRQLNTYGFRKVDPDRWEFANEGFLRGQRHLLKTIKRRKPPSNAPPSQQQSLTSCLEVGEFGFEEEIDRLKRDKNILITEVVKLRQEQQATKDHVKAMEDRLRAAEQKQVQMMGFLARAMRNPEFFQQLAQQKEKRKELEDAISKKRRRPIDNVPFYDPGETSQTEQLDSPYLFDSGVLNELSEPGIPELENLAVNIQDLGKGKVDEERQNQTNGQAELGDDFWAELLVEDFTGKEEQSELDGKIDGIDELAQQLGYLSSTSPK
Protein: Superoxide dismutase 1 copper chaperone (Q59WC0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Superoxide dismutase
- Cu
- Crp1p
- Cell surface superoxide dismutase 6
- Cell surface Cu-only superoxide dismutase 5
- Cell surface superoxide dismutase 4
- Copper metallochaperone
- Multifunctional tryptophan biosynthesis protein
- Copper metallochaperone
- Thiosulfate sulfurtransferase
Sequence:
MTNTFEIVFAVPMECDSCVDSIASVLKGLDGVEKFNINLKDNLVSTEGSLPPSEISKAIQSTGKDAIIRGTGKPDSAAVCILESFDPNDIQHPVKGLARLVEVSPNDLFVDLTVNGLPKGVYYPSIRVSGNLSQGALSTGPSFYELNPIEVKTPVNAETTISSRGAKLEEDSTLYAGQAFLHAKLNINQLIGRSIILSKIKDQVAPDSLCGVIARSAGVWENDKQVCSCSGKTVWQERIDARVKGVHV
Protein: Importin subunit beta-1 (J3QR48)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKE
Protein: Integral membrane protein GPR137C (Transmembrane 7 superfamily member 1-like 2 protein) (Q8N3F9)
Organism: Homo sapiens (Human)
Function: Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:31036939}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MRVSVPGPAAAAAPAAGREPSTPGGGSGGGGAVAAASGAAVPGSVQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLLWAALRTTLFSAAFSLSGSLPLLRPPAHLHFFPHWLLYCFPSCLQFSTLCLLNLYLAEVICKVRCATELDRHKILLHLGFIMASLLFLVVNLTCAMLVHGDVPENQLKWTVFVRALINDSLFILCAISLVCYICKITKMSSANVYLESKGMSLCQTVVVGSVVILLYSSRACYNLVVVTISQDTLESPFNYGWDNLSDKAHVEDISGEEYIVFGMVLFLWEHVPAWSVVLFFRAQRLNQNLAPAGMINSHSYSSRAYFFDNPRRYDSDDDLPRLGSSREGSLPNSQSLGWYGTMTGCGSSSYTVTPHLNGPMTDTAPLLFTCSNLDLNNHHSLYVTPQN
Protein: ATP-dependent RNA helicase RhlE (Q72AL0)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Polyribonucleotide nucleotidyltransferase
- Ribonuclease G
- Bifunctional NAD
- Large ribosomal subunit protein uL3
- Enolase
- ATP-dependent helicase HrpB
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL4
Sequence:
MTFADLSLSPRLLAALDGMGYRQPTPVQRGAIPPALAGEDVLALAATGTGKTAAFVLPMLQRLMDGPRGAVRALVVAPTRELAEQTHDHVRRLGSMSRLRSTTIYGGVGVVAQALRLRAGVEVVVGCPGRLLDHIRRGNLDLSSLEVLVLDEGDSLFDLGFLADVRMLLGMVPATCQRMLFSATMPDAVRVLAAEALRQPVTVQVDAVQPASTVHHALYPVPAHLRTPLLKTFLRSGPEGSVVVFVRTRHGARRLWQQLDNVGFSVTCLQGKLSQRRRLAALEGFRDGRYDVLVATDVAARGLDISQVTHVVNYDVPSTADAYIHRVGRTGRAARNGTAMTFVTPADEAQVRNIERVLGTVIPRERLADFDYGAPVRGPEGARPAMPPRQPRLPAGKRPAAPQEAQEQPRRGRPRPPRHAVPPAAHPPTIPSRLPRQTPAGAEQVDLVRSSRMRGQGGDSDE