wanglab/gogpt-training-data huggingface dataset:
Protein: 3-phosphoinositide-dependent protein kinase 1 (dPDK-1) (EC 2.7.11.1) (Serine/threonine-protein kinase 61C) (dSTPK61) (Q9W0V1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- RAC serine/threonine-protein kinase
- Ribosomal protein S6 kinase
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- phosphatidylinositol 3-kinase
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Serine/threonine-protein kinase N
- Pi3K21B, isoform B
- Atypical protein kinase C
- Forkhead box protein O
- Insulin-like receptor
Sequence:
MKCKSWSNKINNYVVRKIKSIKINGTQQQLQLPGSGASGIAAAAVITVASDCGENCSSNGTEHQQHFNIATTTATSATEATMPAMAKEKASATVSLGESNFRDINLKDLAVVVEAASRLHHQQNVCGCGAVSSTENNNNSRYGSSKYLTNGHTSPLAAAVASNSSSVATTPHCRMLHNCSLQQYQNDIRQQTEILDMLRQQHQQGYQSQQQQQQPQQQQEQQQQQEQSQQQQQLQNPAPRRSPNDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYLPGVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDLNDAEKLQRLEQQKTDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAYGDPSSTSAVSCSSGSSNSLAVISNSSAASSSNSPTVKRSSPVNAPQASTASDNRTLGSTRTGTSPSKKTASK
Protein: Guanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3) (Q9H0R5)
Organism: Homo sapiens (Human)
Function: Exhibits antiviral activity against influenza virus.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17266443}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:21151871}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. {ECO:0000269|PubMed:21151871}.
Interaction partners:
- Guanylate-binding protein 2
- Guanylate-binding protein 1
- Signal transducer and activator of transcription 1-alpha/beta
Sequence:
MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI
Protein: Exosome complex component RRP42 (Ribosomal RNA-processing protein 42) (Q12277)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP42 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Exosome complex exonuclease DIS3
- Exosome complex exonuclease RRP6
- Exosome complex component CSL4
- Exosome complex component RRP4
- ATP-dependent RNA helicase DOB1
- Exosome complex component RRP46
- Exosome complex component RRP40
- Superkiller protein 7
- Exosome complex component SKI6
- M-phase phosphoprotein 6 homolog
Sequence:
MSLSVAEKSYLYDSLASTPSIRPDGRLPHQFRPIEIFTDFLPSSNGSSRIIASDGSECIVSIKSKVVDHHVENELLQVDVDIAGQRDDALVVETITSLLNKVLKSGSGVDSSKLQLTKKYSFKIFVDVLVISSHSHPVSLISFAIYSALNSTYLPKLISAFDDLEVEELPTFHDYDMVKLDINPPLVFILAVVGNNMLLDPAANESEVANNGLIISWSNGKITSPIRSVALNDSNVKSFKPHLLKQGLAMVEKYAPDVVRSLENL
Protein: Voltage-gated sodium channel (F7IVA8)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- 23S rRNA
Sequence:
MQRMQAFIDRPGFGRFITAVIMLNAVVLGMETSPYLMERWGGLILAADRICLGIFIVEIALKLTAQRQRFFLNGWNLFDFVIVGIALIPAAGGLSVLRALRILRVLRVISVAPRLRRVVEGFITALPGMASVFLLMTIIFYIGAVIATKLFAASFPDWFGDLGLSAYTLFQIMTLESWSMGIVRPVMQVYPYAWLFFVPFIMITTFAVVNLLVGLIVNSMQDAHHAEDGERTDAYRDEVLARLEQIDQRLNALGETKK
Protein: Endophilin B, isoform D (A8DYJ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNINLPNFNVKNLVKEAGSTISRVVQLTEEKLGTTERTEYDLHFQNLAERADVTKTWTEKIVRDTESVLIPNPQNRVEDFIFEKIEKSKPKRLSNLEHLALDMIEAGGDFGQDLPYGQALIKVGQAEQKLGQCEHDFIATSGICFTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSAERDLRVAQAEFDRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCGDVMEQLQRELAKMQHPKPRLRINSEDVDCGPPSSVSMHSCDSDSLGGIALDSDPDPDLDKSLTNLLEDFHIEFDTTAVSTVIFVTECSPVNEDYMYGKQGLLKGLVPRAFVEMLDEEHDVTL
Protein: Mineralization regulator ANKH (ATP carrier protein ANKH) (Progressive ankylosis protein homolog) (ANK) (P58366)
Organism: Rattus norvegicus (Rat)
Function: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9HCJ1}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Sequence:
MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFAGPMSDFKNVGLVFVNSKRDRAKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYRNIHDIIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLANTNNTVTSAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVIPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLITSLVVLPYLGVHGATLGVGSLLAGFVGESTMVALAACYVYRKQKKKMENESATEGEDSAMTDMPPAEEVTDIVEMREENE
Protein: Erythrocyte membrane protein 1, PfEMP1 (Q8I1V6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MAPTSGGGGTKDESAKHALDSIGKRVHAQVQNEAKQRSNGDLKGLLTSATLSGGESAFTENPCELIKEKREKLLGARGERNPCGNGSASEKRFSEVSGGECDDKKIEGNGRNNGGACAPYRRLSLCNKNFQKINNYDSSKAKHNLLVDVCMAANYEAQSLIPYHDQYDATYPGSDFSMCTMLARSFADIGDIIRGKDLYRGKKKKKQNGKETETERDQLESKLKEIFGDIYNELTNGRNGVKDHYQDTTDYFQLREDWWTANRHTVWKAITCGTHEGDTYFRPTCSNRQGPSQAHHYCRCNGDKPDDDKPNTDPPTYFDYVPQYLRWFEEWAEDFCRKKKKYVDIVKKYCRGVYNDVPRYCSRNGYDCEQTIYKKGYFVIDKGCINCLYACNPYVEWIEKQKEQFDKQKKKYTDEINEASRSSRRQKRGARSTGSSSNYDGYESKFYNILKDDYGTVDDFLKLLNKEKSCQAVKDNDGGTINFTEKNDDKNNNNKDKGTFYRSEYCQVCPDCGVKYNGSGWEEKKKNDQCNIKLYKPKKDAPHTPIKILKSGEGKEEIEKKLEAFCDKKDGGNSDSSLYDPWQCYQFDQLEKDEKEEGVDDRNYDNDVRTGGGLCILPNQKKNKEEGANTSEKDHDEIQKTFNPFFYYWVAHMLKDSIHWKKKLEKCLQNGTKTRCRNNEKCNKECECFQRWVEKKKTEWGKIKDHFKTQNIGDETNCDPIVTLEGVLKLQFLNEDSTQDKQNSLDSEELKHLKHLSEMLQETSGDGLTCGASDNEKETLMDKLIEHEEGIAKECLRKQNECEKKAKPEGRSDSHDDPQPPDDADNEDDLDDEDDEDEEEEVQVEDNTQEEGEQPVVPQQEEGSSSPTPAPAGPDVCDIVSQLFSDPSQFSDACTLKYVTGKNYGWKCIPSGNTSDTTGSESEATGARQRRDTDSSGDTTGGKDGATGGLCIPPRRRRLYVGGLSQWASQRTQGETSSQSGENLLEAFIQSAAIETFFLWHKYKAENTKTQGVGAGGADFLPATSSVATALAPGAVPSRPSLQLLSGVGVPGEPGMAPGVKSIPVPPLGVGVGGIPGVGALGGGALGPGGPVGLDGVPGQAQPLTLLRPGVLGNGLQSPQSRLRTLDGHFAGGESEDKTPQQWLQQGHIPPDFLRLMFYTLADYRDICIGGDRDIVGDTIVSNTEGSSSSKIKISEKIKEILNHDNKQEPAPKPSVEKTTPTEWWSQNGQHIWNGMICALTYTDSGGSITEDKDVRDKLIDKDTGKPQKNGDNDYTYEKVELKDDESGPKGNDTIQPATLKDFVEIPTYFRWLHEWGSDFCGKRARMLKDVKDNCRNIDKAGHHYCSGDGYDCTRDVIERNDKFVDLNCLGCYKQCRKYKKWIDIKFVEYHNQEKKYKDEYGKLTKDKSSDDKKLEGYKCAENFLKELKHCKPSEDNNDQDNKINFDKPEKTFNPSKYCKACPVYGVKYIGGNYIPNEEKDYKSKKGRVKKENDTIPKNIEVLVLGRKGEEKDKDKHLHDACKNTGLFEVARYEQWNCQKKKGIDQCKITKFANDIDFDKDIVFNEFFQRWLRYFVQDYNKLKDKINPCTKKETEKEKEKSYKCTQGCNDKCECVKEWLSKKKQEWTQIKTLYKQYSKISDQEIAFRVKSYFVDQGLFDNDYKKAQEVVEKPCDKEKLWGCTGDNLKEGEDPGKCHMGDFITNLISKLQKKIDDCNKNQAQNSVETQPSDENTAQCQDTHPDDEEDLLLEENENQVAQPNICPNQVEDKKIEEEVEKCETAQTTAEETAAAGGERQTPPAPAPAAPPSPPRPLPKPKPPKPDLPPALKNAMLSSTIMWSVGIGFAAFTYFFLKKKTKASVGNLFQILQIPKGDYDIPTLKSSNRYIPYASDRYKGKTYIYMEGDSSGDEKYAFMSDTTDVTSSESEYEELDVNDIYVPGSPKYKTLIEVVLEPSGNNTPTSDIPSDNTPTPQPITDDEWNQLKHDFISNMLQNTQNTEPNILHDNVDNNTHPTMSRHNMDQKPFIMSIHDRNLFSGEEYNYDMFNSGNNPINISDSTNSMDSLTSNNHSPYNDKNDLYSGIDLINDALSGNHIDIYDEMLKRKENELFGTQHHPKNITSNRVVTQTSSDDPIHNQLNLFHTWLDRHRDMCEKLKNDNERLAKLKEEWENETHSGDINSGIPSGNHVLNTDVSIQIHMDNPKPINEFTNMDTSPDKSTMDTIIDDLEKYNEPYYYDFYEYDIYYDVNDDDKTSMDNNNNLVNKNNPVDSNSSTYNHHNPADINKTFVDINNHNQHPIEKPTKIQIEMNSNNREVDEQQYPIADIWNI
Protein: Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III) (P14669)
Organism: Rattus norvegicus (Rat)
Function: Inhibitor of phospholipase A2, also possesses anti-coagulant properties.
Interaction partners:
Sequence:
MAASLWVGPRGTINNYPGFNPSVDAEAIRKAIKGIGTDEKTLINILTERSNAQRQLIVKQYQEAYEQALKADLKGDLSGHFEHVMVALITAPAVFDAKQLKKSMRGMGTDEDTLIEILTTRTSRQMKEISQAYYTAYKKNLRDDISSETSGDFRKALLTLADGGRDESLKVDEHLAKKDAQTLYDAGEKKWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIEDSIKGELSGHFEDLLLAVVRCTRNTPAFLAGRLHQALKGAGTDEFTLNRIMVSRSEIDLLDIRREFKKHYGCSLYSAIQSDTSGDYRTVLLKICGGDD
Protein: Flavanone-3-hydroxylase (A2IBF9)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MAPSTLTALAEEKTLQASFVRDEDERPKVAYNQFSNDIPVISLAGIDDVDGKRGEICKKIVEACEDWGVFQVVDHGVDTKLVSEMTRFAREFFALPAEEKLRFDMSGGKKGGFIVSSHLQGEAVQDWREIVTYFSYPLKSRDYSRWPDKPEGWIEVTKEYSEKLMGLACKLLEVLSEAMGLEKEALTKACVDMDQKVVVNFYPKCPQPDLTLGLKRHTDPGTITLLLQDQVGGLQATRDNGKTWITVQPVEGAFVVNLGDHGHYLSNGRFKNADHQAVVNSNCSRLSIATFQNPAPDATVYPLKIREGEKPILEEPITFAEMYRRKMSKDLELARLKKLAKEQQQLKEKEAENEKPKLEAKPLEEILA
Protein: Putative cytochrome P450 123 (EC 1.14.-.-) (P9WPP5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Sterol 14alpha-demethylase
- Probable oxidoreductase
- Probable aldehyde dehydrogenase NAD dependent AldA
- Nuclear transport factor 2 family protein
- Polyketide synthase Pks13
- Ferredoxin Fdx
- Probable oxidoreductase
- Uncharacterized HTH-type transcriptional regulator Rv0767c
- Uncharacterized oxidoreductase Rv0770
- Phosphoribosylamine--glycine ligase
Sequence:
MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
Protein: Serine and arginine rich splicing factor 2 (J3KP15)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSRRGPPPRRYGGGGYGRRSRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRSTSKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRSKSPPKSPEEEGAVSS
Protein: SOS Ras/Rac guanine nucleotide exchange factor 1 (D4A3T0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Growth factor receptor-bound protein 2
- Tyrosine-protein phosphatase non-receptor type 11
- Receptor protein-tyrosine kinase
- SHC-transforming protein 1
- GTPase HRas
- Focal adhesion kinase 1
- GRB2-associated-binding protein 1.
- GTPase NRas
- SHC-transforming protein 3
- Epidermal growth factor receptor kinase substrate 8
Sequence:
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNEDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPAERIHHLLREVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSSYDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDVLRPGFHERFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECMKQAITALLNVQSGMEKICSKNLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTSEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEHMRLPSADVYRFAEPDSEENILFEENVQPKAGIPIIKAGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLNLLIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDVDLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQNSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKELINFSKRRRVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTPLTPPPASSASSNTDVCSVFDSDHSASPFHSRSASVSSISLSKGTEEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQLIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS
Protein: Increased recombination centers protein 19 (Respiratory growth protein 4) (Q07843)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in sporulation and maintenance of the mitochondrial DNA. Is probably involved in a pathway contributing to genomic integrity.
Interaction partners:
- Protein YPR117W
- Putative increased recombination centers protein 14
- Uncharacterized protein IRC4
- Uncharacterized protein IRC9
- Required for respiratory growth protein 8
- Protein PET130
- Required for respiratory growth protein 7
- Genetic interactor of prohibitin 5, mitochondrial
- Regulator of rDNA transcription protein 7
- Required for respiratory growth protein 9
Sequence:
MRKPSITITTAKAIITPDYTLIKSHSKYQLPSRFQKLDADSPERSTVVKLFYRRFMRLKPFISNVKMVKDTYRDYVRYKFMKENYELKRYLVFNPDGLRSKINLELLSNTKCCERILPVTEMQRTLEFVLKSCSYLPETKVQKWDIARDNTYCRQILKNLLTMQYEKYRSILHRGIGHDELDVKFSHLKTTSSPLTKLNKTEKKKIPLFKVFSDFDTTLIYLNETLGTRL
Protein: Delta(14)-sterol reductase (EC 1.3.1.70) (C-14 sterol reductase) (C14SR) (MaSR1) (Sterol C14-reductase) (G4SW86)
Organism: Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) (Methylomicrobium alcaliphilum)
Function: Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. Complements the deletion of the Delta(14)-sterol reductase gene ERG24 in yeast.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:25307054}; Multi-pass membrane protein {ECO:0000269|PubMed:25307054}.
Interaction partners:
- Lanosterol 14-alpha demethylase
- Lipid biosynthetic enzyme, related to human 24-dehydrocholesterol reductase DHCR
- C-8 sterol isomerase
- (S)-2,3-epoxysqualene cyclase
- squalene monooxygenase
- Lipoprotein signal peptidase
- Disulfide bond formation protein B
Sequence:
MSEQESRDNAAVDAVRQKYGFGFSWLVLMIALPPLVYYLWICVTYYQGELVFTSDAAAWRRFWSHVAPPTWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQWERPTGRPFYDYFMGTALNPRIGSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY
Protein: Signal transducer and activator of transcription (A0A0G2JXH1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
Sequence:
MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQDWEVASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSILVNQEVLTLQEMLNNLDFKRKEALSKMTQIVNETDLLMNSMLLEELQDWKKRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQLEKLQEQSTKMTYEGDPIPAQRVHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHIKAMSSEESSNGSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSDQLNMLAEKLTVQSNYSDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHSVEPYNKARLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTM
Protein: Regulator of telomere elongation helicase 1 homolog (EC 5.6.2.-) (F4HQE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent DNA helicase implicated in DNA replication, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also plays a role in preserving the stability of 45S rDNA repeats.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- MMS19 nucleotide excision repair protein homolog
- Crossover junction endonuclease MUS81
- Exonuclease 1
- Pentatricopeptide repeat-containing protein At4g30825
- DEAD-box ATP-dependent RNA helicase FANCM
- ATP-dependent DNA helicase Q-like 4A
- General transcription factor IIH subunit 2
- General transcription and DNA repair factor IIH subunit TFB4
- General transcription and DNA repair factor IIH subunit TFB2
- Telomerase reverse transcriptase
Sequence:
MGFTVVSRSGSPTRRENQKRRVCFRLLLRLLRRGFVVLSAESDPKMPNYSIRGINVEFPFEAYQSQIIYMDRVIESLQNKCHALLESPTGTGKTLCLLCATLAWRKSLGSFSTRKDRKNSAIPWSDSDEPLSQSGGGGGGAFPTIVYASRTHSQLRQVIKELKRSSYRPKMVVLGSREQLCVNEEVNSLRGKALTNACQYLCKKRGKRQCNHFNRLPDYLKHNPHIGDEPVDIEDLVNIGKDSGPCPYYITRELHKDVDIIFAPYNYLISNGYRKFLKVNWTNSVLIFDEAHNLESLCADSASFDLPSVLLSACISEAQECVQLAAARRDSLNDVSINPENFAILKGLLLKLQELISKVPIPKRDEGFTKPGPYIYEMLKSLNITHETAPKLIGTVEEAAVFLEEEKQRTATNAGSKLEIIADMLKLIFRENGSNHADVYRVHVQELEQNSTDVMKGKVSRTLSWWCFSPGITMLDIAQKGVGSIILTSGTLSPMDSLAQELKLDFPIRLENPHVISSNQLWAGVVSTGPSGYVLNSSYRNRDVPEYKQELGNAIVNFSRVVPEGLLIFFPSYYLMDSCITFWKNGCYRNSMTVWERICKLKKPVIEPKDSSLFPAAMRDFSEKLQDRATSGVVFFAVCRGKVSEGLDFADGAGRAVVITGLPYARVTDPRVKLKREFLDEQSQLADVKLPRSTLLSGSMWYSQEAARAVNQAIGRVIRHRHDYGAIIFCDDRFEQPSQQSKISLWIRPNVKCYSRYGEVISDLARFFRTERSNFPARLVTEQENNIVSTLLPVESIEDNPTPAFGNSNLKNVGVAQNELSRLEAFPPANRASPLERDGNNVKRNGLTILKHTGKIPRIVKGDVMQGCSSRKAKLVELSDDEETPVERRCEVVDLESDNCETQTCVTEVLASSTCLNTMGLKKKRKVPESQGSASSSVLTAKGNGGGDKKEASASAFLSQVKEKLNTEEYKKFIGYMQALKKKEIKLANVMQSIVQLFCGSERDHLLMGFKDFVPVKYRPAYEECIKTRKRQSIIFGNSN
Protein: Growth factor receptor-bound protein 10 (GRB10 adapter protein) (P0CE43)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). {ECO:0000250}.
Interaction partners:
- Insulin-like growth factor 1 receptor
- E3 ubiquitin-protein ligase NEDD4
- Insulin receptor
- Serine/threonine-protein kinase mTOR
- Insulin-like growth factor 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Insulin-like growth factor 2
- Insulin-2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Insulin receptor substrate 1
Sequence:
MNNDINSSVESLNSACNMQSDTDTVPLLENGQSASNQPSASSSRGQPQASPRQKMQRSQPVHIQPLRRLQEEDQQLRTSSLPAIPNPFPELAGGAPGSPPSVAPSSLPPPPSQPPAKHFPPGFQLAKLTRPGLWTKTTARFSKRQPKNQCQTDTANAVSRIPTSQMEKLRLRKDVKVFSEDGTSKVVEILTDMTARDLCQLLVYKSHCVDDNSWTLVEHHPQLGLERCLEDHEIVVQVESTMPSESKFLFRKNYAKYEFFKNPVNFFPDQMVTWCQQSNGGQAQLLQNFLNSSSCPEIQGFLQVKEVGRKSWKKLYVCLRRSGLYYSTKGTSKEPRHLQLLADLEESSIFYLIAGKKQYNAPNEHGMCIKPNKAKIEMKELRLLCAEDEQIRTCWMTAFRLLKYGMLLYQNYRIPQQRKGLAPPFNAPMRSVSENSLVAMDFSGQIGRVIDNPAEAQSAALEEGHAWRKRSTRMNILSSQSPLHPSTLNSVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHQQKIRNFQILPCEDDGQTFFTLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
Protein: General transcription and DNA repair factor IIH subunit ssl1 (TFIIH subunit ssl1) (RNA polymerase II transcription factor B subunit ssl1) (TFB subunit ssl1) (Suppressor of stem-loop protein 1 homolog) (SSL1 homolog) (TFIIH basal transcription factor complex p47 subunit) (O74995)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- RNA polymerase II transcription factor B subunit 3
- General transcription and DNA repair factor IIH subunit tfb2
- General transcription and DNA repair factor IIH subunit tfb4
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH subunit tfb1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor IIE subunit alpha
- Transcription initiation factor IIA subunit 2
- Transcription initiation factor IIA large subunit
Sequence:
MNENQKSFDSDKSESEDEQKNGRVKVRSRKTDDNEGYTWEGEYQRSWDIVQEDAEGSLVGVIAGLIQSGKRKRLLRDTTPLQRGIIRHMVLVLDLSNSMEERDFHHKRFDLQIKYASEFVLEFFEQNPISQLSIIGVMDGIAHRITDLHGNPQSHIQKLKSLRDCSGNFSLQNALEMARASLSHIASHGTREVLIIFGSILSSDPGDIFKTIDALVHDSIRVRIVGLAAEVAICKEICNKTNSSTKNAYGVVISEQHFRELLLESTIPPATDSAKTTDASLVMMGFPSKVVEQLPSLCACHSIPSRGGFHCPRCKAKVCTLPIECPSCSLVLILSTHLARSYHHLFPLKNWSEIPWSANPKSTHCFACQLPFPKPPVSPFDESTSSMRYACPSCKNHFCLDCDVFAHEQLHECYGCQCSGN