wanglab/gogpt-training-data huggingface dataset:
Protein: Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2) (Two pore K(+) channel KT3.2) (Q9NPC2)
Organism: Homo sapiens (Human)
Function: pH-dependent, voltage-insensitive, background potassium channel protein.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23169818}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q3LS21}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q3LS21}. Note=Colocalizes with MAP2 in the soma and proximal dendrites of dentate gyrus granule cells. {ECO:0000250|UniProtKB:Q3LS21}.
Interaction partners:
- Potassium channel subfamily K member 3 channel 1)
- Keratin, type II cytoskeletal 2 oral
- Potassium channel subfamily K member 5 channel 2)
- Potassium channel subfamily K member 1
- Potassium channel subfamily K member 10
- Potassium channel subfamily K member 18
- Potassium channel subfamily K member 4
Sequence:
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV
Protein: Protein BIG1 (Bad in glucose protein 1) (P38813)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for normal beta-1,6-glucan synthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12112232, ECO:0000269|PubMed:14562095}; Single-pass type I membrane protein {ECO:0000269|PubMed:12112232, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein ROT1
- Killer toxin-resistance protein 5
- Glucosidase 2 subunit alpha
- Calnexin homolog
- Mannosyl-oligosaccharide glucosidase
- Cell wall synthesis protein KRE9
- Dolichyl-phosphate beta-glucosyltransferase
Sequence:
MQTVLKYLLLIMCGSFCASEELQNQTNVPAIFFSYKLTPGILKYQEDYDRAVTLPRDTFIEAAEKFLGVCNADTYVFINQPGLRKLDFLEFETEFVSLQRYIRRSSTAIKFEKVDLLPQDLYYDLAEFVKEYCNVDQVLNLRGNNTEDFQPFIDSEKRVIIIEYPKLPEDTNERKEAFRHYDKYLRTILAQIPSPEQNVIYTSLNPGTTLAHESIIPIQIFPDIFDIKSRVGEVEQNNRVLDVPRLSFNDYTPRFSEPPSEYVSIFDSQLIENNRGLLQLIFTILVGYILIQFFFTKKTIVDEKITNKKDNVKQTSPQLLKKVQEIQKKPSQQVS
Protein: Ubiquitin carboxyl-terminal hydrolase YUH1 (UCH) (EC 3.4.19.12) (Ubiquitin thioesterase) (P35127)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or RUB1. Preferentially cleaves ubiquitin from peptides and small adducts.
Interaction partners:
- Polyubiquitin
- NEDD8-like protein RUB1
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40A fusion protein
- COP9 signalosome complex subunit 5
- Ubiquitin carboxyl-terminal hydrolase RPN11
- NEDD8-activating enzyme E1 catalytic subunit
- Ubiquitin carboxyl-terminal hydrolase 6
- Ubiquitin carboxyl-terminal hydrolase 1
- Ubiquitin-activating enzyme E1 1
Sequence:
MSGENRAVVPIESNPEVFTNFAHKLGLKNEWAYFDIYSLTEPELLAFLPRPVKAIVLLFPINEDRKSSTSQQITSSYDVIWFKQSVKNACGLYAILHSLSNNQSLLEPGSDLDNFLKSQSDTSSSKNRFDDVTTDQFVLNVIKENVQTFSTGQSEAPEATADTNLHYITYVEENGGIFELDGRNLSGPLYLGKSDPTATDLIEQELVRVRVASYMENANEEDVLNFAMLGLGPNWE
Protein: EscI protein (EscI/YscI/HrpB family type III secretion system inner rod protein) (ST20 protein) (T3SS component) (Q9AJ18)
Organism: Escherichia coli
Interaction partners:
Sequence:
MDALCHYLSHEKRLTVNMNNINQSENINIHFNKVSQTNFVDDHTPLAPTPSAAGAAQFLDQLLPKTAGVSSPEQVLIEEIKKRHLATMNTDLSFDALSAGGLSPEDVLTLQKNVLNANVNVDVVSKLASLLSTSVTKLVSMQ
Protein: Intraflagellar transport protein 20 homolog (hIFT20) (Q8IY31)
Organism: Homo sapiens (Human)
Function: Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity).
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q61025}. Cell projection, cilium {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61025}. Golgi apparatus {ECO:0000250|UniProtKB:Q61025}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q61025}. Cytoplasm {ECO:0000250|UniProtKB:Q61025}. Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia. Detected in the Golgi apparatus of round spermatids and late spermatocytes. Also detected in the manchette of step 10-12 spermatids. In step 14 spermatids, found in the basal body of the sperm tail. Localization in the manchette of elongating spermatids is dependent on SPAG17. {ECO:0000250|UniProtKB:Q61025}.
Interaction partners:
- TRAF3-interacting protein 1
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 80 homolog
- Thyroid receptor-interacting protein 11
- Intraflagellar transport protein 172 homolog
- Intraflagellar transport protein 52 homolog
- Clusterin-associated protein 1
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 27 homolog
Sequence:
MAKDILGEAGLHFDELNKLRVLDPEVTQQTIELKEECKDFVDKIGQFQKIVGGLIELVDQLAKEAENEKMKAIGARNLLKSIAKQREAQQQQLQALIAEKKMQLERYRVEYEALCKVEAEQNEFIDQFIFQK
Protein: Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Glial growth factor receptor) (Proto-oncogene-like protein c-ErbB-3) (Q61526)
Organism: Mus musculus (Mouse)
Function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Pro-neuregulin-2, membrane-bound isoform
- Epidermal growth factor receptor
- Pro-neuregulin-1, membrane-bound isoform
- Receptor tyrosine-protein kinase erbB-2
- Pro-epidermal growth factor
- Protransforming growth factor alpha
- Receptor tyrosine-protein kinase erbB-4
- SHC-transforming protein 1
- Growth factor receptor-bound protein 2
- Amphiregulin
Sequence:
MSAIGTLQVLGFLLSLARGSEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHMDTIDWRDIVRVPDAEIVVKNNGGNCPPCHEVCKGRCWGPGPEDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGTSTCNGSGSDACARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQAEVLMSKPHLVIAVTVGLTVIFLILGGSFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRASGPGIPPAAEPSALSTKELQDAELEPDLDLDLDVEVEEEGLATTLGSALSLPTGTLTRPRGSQSLLSPSSGYMPMNQSNLGEACLDSAVLGGREQFSRPISLHPIPRGRQTSESSEGHVTGSEAELQERVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDGNGYVMPDTHLRGTSSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRKRRGSPARPPRPGSLEELGYEYMDVGSDLSASLGSTQSCPLHPMAIVPSAGTTPDEDYEYMNRRRGAGGSGGDYAAMGACPAAEQGYEEMRAFQGPGHQAPHVRYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRI
Protein: 2'-dehydrokanamycin reductase (EC 1.1.1.355) (Kanamycin biosynthesis protein K) (Q2MFU6)
Organism: Streptomyces kanamyceticus
Function: Mediates the conversion of 2'-dehydrokanamycin A into kanamycin A.
Interaction partners:
Sequence:
MSSQLALRGPELSANLCKPEEDTLRVLVTGGSGNVGVGVVRALNAARHHVVVASRGYSPALLPEGVRAVRLERTEPDAYTRLVAAEKPDAVIDLTCHDAADAAVTLRACAGVDRVVVVSSVTAAGPATTTPVTEATAAPPLSEYGIDKLAVEETVRAAWADGTSQALLVRLGAVYRLGADLDGQLAEDGCWLAHAAAGAPAVLADDGAARWNLLHADDAGAALAELLANDRARGVLVHLASRHPLPWRELYERVHHALGRPFNPVSVPAEWAAEQLEDAEFLAETSRWDQVFDLGLLDRLAPSYQERGGPSRVTEVALWLIRQGRVGDAELGAEIQELPARLAAVRTAPGLV
Protein: Tetraspanin-18 (TOM2A homologous protein 2) (Q93XY5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the regulation of cell differentiation.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}. Vacuole membrane {ECO:0000269|PubMed:17151019}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 71B26
- At2g45180
- Curculin-like
Sequence:
MRRNCCHVSFASTLKILNFVQAFIGVSIIIYSIWMLHEYSRHLPVDPPPSASSSSGTEIATSVSEPLKNPIDFVASIILGSNGGDHGFNLRSLDLPAPWFIYSFMAVGILVCIVTFIGFIAAEAINGCCLCFYSILKTLLILLEAALVAYIAIDRHWEKDLPYDPTGELSSLRAFIEENIDICKWVGIAVVAVQLLSLLLAMVLRAMVSTPKPELDEEEDDENPRSRTWDPLLGPQGNQAPAGSSKIENWSSRIREKYGLNQSPPVNPKG
Protein: Histidine triad missing (Wpkci) (Q9I871)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Spindlin-W
- Uncharacterized protein.
Sequence:
MAGGIVRSPAAWRGGAALLGKVARQEFSANVIREEEPLWTRSALRSMIFHRKLLRFFLAAPQKAVVGLSGAEDCGAPLLGHLMIVGEKCAASLGLTDGFRMAVRYPPSVPSDYRARLCILGGRQLGQPPG
Protein: Anaphase-promoting complex subunit 4-like WD40 domain-containing protein (Q54XN8)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Cleavage and polyadenylation specificity factor subunit 3
- Cleavage and polyadenylation specificity factor FIP1
- CPSF domain-containing protein
- Cleavage and polyadenylation specificity factor subunit 2
- Symplekin
- Histone-lysine N-methyltransferase set1
- Serine/threonine-protein phosphatase PP1
- Retinoblastoma-binding-like protein E
- WD40 repeat-containing protein
Sequence:
MKSTLRLTDNVVQNMGIGKLHKDDNSSVINSMDFNKDGSLLITASDDESIHLYNIDTGELQKTLNSKKYGVDLIKFTHNNNSIICASKNSWDESLRYLSLHDNKYLKYFKGHRNKVVSISMSPINDMFLSGSLDDTIRMWDLRTNVCQGLLRRNGRPAVSFDPQGIIFATAVSVNTIKLYDLRNYDKGPFSSFSIDHPIPVEWTSMKFTADGKYILLSTKTNIIFLIDSFTGEVKQRYTSFKNDNGSVIESSFSPDAQYVLSGSEDGTVHIWKTLTGEEVAVWGGHSSTVGRVQWNPRSMMAATACSNLAFWIPNDSVL
Protein: MADS-box transcription factor 3 (OsMADS3) (Protein AGAMOUS-like) (RMADS222) (Q40704)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor involved in the development of floral organs. Acts as C-class protein in association with MADS58. Involved in the control of lodicule number (whorl 2), stamen specification (whorl 3) and floral meristem determinacy (whorl 4), but not in the regulation of carpel morphogenesis. Plays a more predominant role in controlling lodicule development and in specifying stamen identity than MADS58.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALIVFSSRGRLYEYANNSVKSTVERYKKANSDTSNSGTVAEVNAQHYQQESSKLRQQISSLQNANSRTIVGDSINTMSLRDLKQVENRLEKGIAKIRARKNELLYAEVEYMQKREVELQNDNMYLRSKVVENERGQQPLNMMGAASTSEYDHMVNNPYDSRNFLQVNIMQQPQHYAHQLQPTTLQLGQQPAFN
Protein: DNA 5'-3' helicase (EC 5.6.2.3) (A0A8I6A002)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTITNPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL
Protein: Lipocalin-type prostaglandin D synthase-like protein (Prostaglandin D2 synthase b, tandem duplicate 1 (EC 5.3.99.2)) (Ptgds protein) (Q8QGV5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Prostaglandin E synthase
- Prostacyclin synthase
- Prostaglandin D2 synthase b, tandem duplicate 2
- Prostaglandin G/H synthase 2
- Prostaglandin-endoperoxide synthase 1.
- Prostaglandin-endoperoxide synthase 2a.
- Prostaglandin E synthase 3
- Zgc:153704
- Prostaglandin E synthase 3b
- Prostaglandin E synthase 2
Sequence:
MTSVVVKMLCLLLCAVFASADVMPMTDFDLQKVEGKWYLVGFATNAKWFVSHKDDMKMGTAMLVPTQEGDLDLSYSNLKSDGSCWRMTYLAKKTETPGRFVFYSQRWGNDNDMRVVDAKFDEYAIFHTIKTKGGVSEILNKLYSRTPEMVDDLKEKFRQFCLDTGILEENIVMLPQNGECSVAA
Protein: Homeodomain-like superfamily protein (F4JI72)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MHSDSGEATADGDKASTENSKKRKLKTPMQVMALENFYNEHKYPTEEMKGKLAEEVGLTEKQVSGWFCHRRLKDKRHVKEDGNAIGSQDRSSVVLQDRGSGLRQDSCGSTKQTDYWNPKPREVESQRLYMGNADGEDSTSSDRSSSLRKNLVSSKDGIRDVESSRYVAHKDVIQHPQFMRSYGYNKPSGYLKVKGESENFAITAVKRQLGRQYQEDGPPLGVEFDPLPPGAFEPQTNPIVHEPIYVGNQRRPHLPHLLGTRKSFNPGPSYELARKSKLHSPDPDSEDDEHDDDDNIMVGMEPGLRDKKSFGEPRLKSPSTSFYNSVPRHKSFKETFKGSPREIPVTNSKKGWISSKSWAEGSRNHLVANVQNLSGSNIETNQSHDYDNNISNGGRKTGYLTKSSKLLPPSRSRSPESMDRGPSSGMAGIYHGERNQMKMQREKLHSTDEPPVAKRVKHGYIQQVYAPKSSSYSEILERKSQINRSGVELPSSLSGDDETDESSSSMD
Protein: IP05844p (Nostrin, isoform F) (D5SHR1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGNAQGQNGFEELRRYVKQGGDFSKELIFVLQERADSELIYSKSLSKLANKLNKAGREIPGSVADAWRGVATEMESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAARVLGEWRASEAKAKKASHTAARENEKLQDAMLDVRIQKSPSIALLHQGPNKQAAEKELKSAEKDCVKLDNKRKKAEEAVKRADVEYYTLCVRSERARVDWEMAVLRGSAQLQSSEQQRLGNMHNFAQQYARLISDMNPILGGLSTRLQPQLDACNVAKDMQVVRHIRRNSEGPSEQLLPDFYCEHTTLAMNRERRKHALIKLLQLVKTDLERERRSRDGLRGLSQSLNHQEHQNITDKLYHIRSMLTYLEGARLKLHSALLELDHKPRATHPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITDITTNHEDELPDENCSHLHSSSHSNNNSNGSCTDVSSVVKPFNRSKSNIETNFTSQPKIISTTNAAIAVSVKSKTLANLQDGHHNNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQQQPLLQNPTINGQVQTQHFYQNAQELQKGQKNGSVPILGRCKALYSYTPKLYDELELSPGDIIEVHAKQDDGWWLGALRNHIGIFPATYVEECA
Protein: AP-1 complex subunit sigma-1 (Clathrin assembly protein complex 1 sigma-1 small chain) (Clathrin coat assembly protein AP19) (Clathrin coat-associated protein AP19) (Golgi adaptor AP-1 19 kDa adaptin) (HA1 19 kDa subunit) (Sigma1-adaptin) (P35181)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP19 is probably a subunit of the Golgi membrane adapter. Component of the AP-1-related (AP-1R) complex, an adapter protein complex that mediates sorting of cargo SNARE SNC1. In contrast to the APM1-containing AP-1 complex, AP-1R is incapable of sorting CHS3.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9P7N2}. Nucleus {ECO:0000250|UniProtKB:Q9P7N2}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q9P7N2}. Endosome {ECO:0000250|UniProtKB:Q9P7N2}. Golgi apparatus {ECO:0000250|UniProtKB:Q9P7N2}.
Interaction partners:
- AP-1 complex subunit beta-1
- AP-1 complex subunit mu-1-I
- AP-1 complex subunit gamma-1
- Adaptin medium chain homolog APM2
- AP-2 complex subunit beta
- Clathrin heavy chain
- AP-2 complex subunit alpha
- AP-3 complex subunit delta
- Clathrin light chain
- Epsin-5
Sequence:
MTQLKYLLLVSRQGKIRLKKWYTAMSAGEKAKIVKDLTPTILARKPKMCNIIEYNDHKVVYKRYASLYFIVGMTPDVDNELLTLEIIHRFVETMDTYFGNVCELDIIFNFSKVYDILNEMIMCDGSIAESSRKEVLHHVTVMDTMESNDNLERVLS
Protein: At3g63160 (Outer envelope membrane protein) (Q9M1X3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transmembrane protein
- Transmembrane protein
- GAG1At protein
- Transmembrane protein
- Plastid division protein PDV2
- Transmembrane protein
- AT3g62190/T17J13_150
- Protein TOC75-3, chloroplastic
- Plastid division protein PDV1
- RHOMBOID-like protein 10, chloroplastic
Sequence:
MVEKSGGEVNFPKLEKPTGKKQTATVVVGVLAVGWLAIELVFKPLFKKLSSSKDKSDSDDATVPPPSGA
Protein: Ferric uptake regulation protein (Q8YU81)
Organism: Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Interaction partners:
Sequence:
MRAIRTRSQERILNLLQTIKQGISAQDIYVELRNRNQSMGLATVYRSLEALKLEGLVQVRTLPNGEALYSLAQQDKHHLTCLQCGVSIPIHQCPVHNLEEQLQTAHKFKIFYHTLEFFGLCGKCQMNHASEI
Protein: pH-response regulator protein palA/RIM20 (P0CM46)
Organism: Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Function: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity).
Interaction partners:
- Vacuolar-sorting protein SNF7
- Calpain-like protease palB/RIM13
- pH-response transcription factor pacC/RIM101
- ESCRT-I complex subunit TSG101
- Magnesium-dependent phosphatase-1
- Vacuolar protein sorting-associated protein 4
Sequence:
MSNFLPIPTKAATPLPSFAKHLLDYISAHFRDTHSEAFRKDVDVLVGMRKDWVEAKLEAHPEIIRAFMRYHAQLAFLSTKFPSDINLPFAYYLPFPATFSLSPDAPISLSSLTFERACVLFNMTALYASMAAAERRAEAEGIKRALGYLTAAAGVLEYLITSVLPTLRSELSSPQAAGYDMTESFLGTLKEFVLAEAQECYWQQAVLQGTYKNGLIGKLSMKVSEYYKAALASMNGTDYPSSSYFPLNWTAHMNVKQMHFEAAAQFRLSQEDLEKSRYGEEIGRLKVAESLAKKGLDAARKGVADSVVSDLKQLHAAIKSSLERAVRDNDLVYVQPIPPANQLAPIVGVGMVKVNVPAEVAEPVAWLMGGKAGMEPLFSGLVPYGVHLALSIYDDRKDTLVRDLDGKREELDGLAASTLQSLNLPGSIQALDRPVGLPPSLLKKSEEVASSGGIERIRSLLDEVNRLAHANVQSLNEAMDILDQEATENESLIARQPELQQTRQPSHVANQPLIQMAEQYEATIKQAGGSDATVRAKWEEWARLVGILAAGEMEMEDYVPGTTSPSGSLPPSVRPLRASLEELDDRIAHRARLVREARQISAADDIRPEVLKEAAKLAHGGSGDVKTEWFEDLFEKGLEKYMGVKREMDEEVAKHDELLEQIRTQNESFLSERKDDPIIKERERRLQDMDLAYWKWREIVDNAEEGIKFYNSFAEMLHGFKAACGQFLNTRRIDVGQMTTQFQQQMNVSEPQQQPEPRYQSPSPQSFQPSFSPSPSHFQPSAPSSFSSSPVRSPAPSAPARRESPPKTLSFLPHPSSSAWQPASVDFLPPPPPPPILRSGGIQSQPKVAPPVTPSITAIRDQTQGTPRRMTRAAAAAAERDEATERNKYSSGGPRRKGGGVV
Protein: Progonadoliberin [Cleaved into: Gonadoliberin (Gonadotropin-releasing hormone) (GnRH) (Luliberin) (Luteinizing hormone-releasing hormone) (LH-RH); GnRH-associated peptide (GnRH-associated peptide)] (Q5Y835)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU000635}.
Interaction partners:
- Progonadoliberin
- Gonadotropin-releasing hormone receptor 1
- Type II GnRH receptor
- Gonadotropin-releasing hormone receptor 2.
- Lhb protein
- Kisspeptin
- Mitochondrial ribosomal protein S22.
- Follicle-stimulating hormone beta subunit
- Mitochondrial ribosomal protein S28.
- KiSS-1 metastasis suppressor
Sequence:
MVLVCRLLLVMGLMLCLSAQLSSAQHWSHGWYPGGKREIDLYDTSEVSEEVKLCEAGKCSYLRPQGRNILKTILLDALIRDFQKRK
Protein: Caspase recruitment domain family member 14 (A0A494C1N2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGELCRRDSALTALDEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLDYELLDTADLPQLESSLQPVSPGRLDVSESGVLMRRRPARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQVHCNEVLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPNYSRAQQQLIALIQDMTQQCTVTRKPSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRMEGEAWILSSTGSSTCFWAESCLTLVPYTLVRPHRPARPRPVLLVPRAVGKILSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWTEQSPR
Protein: Tropomodulin (Q8I7M7)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Tropomodulin
- Actin
- Adducin-related protein 1
- Adducin-related protein 2
- Profilin-3
- Actin-depolymerizing factor 2, isoform c
- Myosin, essential light chain
- Gelsolin-like protein 1
- Profilin-2
- Profilin-1
Sequence:
MEEELQQLRTNASSDLMTDEDFIATIESMGVEAQEREINDLLKAMHENRIVSWDEAERILMETDQTPIKCSLPEQTRPTEPENEVDVDQCIKKLLDNDPSLKEINLNNMKRTPVPAIKRLLEALAYNEHCERISLANMGLYDHDINVLVTVIEMNQAIKKVNLETNYLSGDFFSKLFKAALVNESVEEIKAVNQGVSFSTQSEKEIIDAIVKNHGLTKISINFRLPEGRHKVENATLRNGELKRVKRREAAQKARLEAEELAKNPVPKLAPEPKKEPEPKKMAPKIPPAVPKSLVSPEPKPSLAPKAAPVIATAPPKSTILMKQLSFQRASRESEEDTEFVPPPAVPEPPKKLAIPKTFMKKEETPSFQKVAKRPTRQWEPKKQESLEQEEHKETVKEEVKKEEVKEKVPAKVERKHWEPKVAPAPVIDGYAPILDVSGNAAPSTAKPKLDGAPIRAKRPPITAKNIWEQRMAKIEKKEEKKKPLLSIQKIREMEKNDVIKKEEDDRLEQLLKKEKEPKKLNNEHRKLFENGNVAQKKPEPRRHVQKLIAKKPNSILNQTEPTKIEGPDKQETRPTTVIRRTVIRKKEEMVPSEKPEVSENEKPKRRLVRKKKVVEGDGMNGTNGHQSHLTSAPPQAVH
Protein: Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb) (P19536)
Organism: Mus musculus (Mouse)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}; Peripheral membrane protein {ECO:0000269|PubMed:34616041}; Matrix side {ECO:0000269|PubMed:34616041}.
Interaction partners:
- Cytochrome c oxidase subunit 3
- Cytochrome b-c1 complex subunit 9
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 6C
- Cytochrome c oxidase subunit 6B1
Sequence:
MASRLLRGVGALAAQALRRTARGAAVTRSMASGGGVPTDEEQATGLEREIMIAAQKGLDPYNMLPPKAASGTKEDPNLVPSISNKRIVGCICEEDNCTVIWFWLHKGESQRCPNCGTHYKLVPHQMAH