wanglab/gogpt-training-data huggingface dataset:
Protein: Integrin beta-like protein B (Q54JE1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Implicated in cellular adhesion.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Latrophilin receptor-like protein A
Sequence:
MKNIIKYLFIFLCFLIITEATHFRYGTISWAPTTKYNNIKITVNLAFRTGYWGSVAIGQQISHGNIDFGDNTKTGLTMTVTSKDTDNEWFTATWSGIHEYSPQPTAQTKNYIVVYKDCCRISTLLNNGDQYWHISAGIQIDSSNAFPNVNWSPVTNMMPIVRVIANKNNNFRIIANDQNKQTALSYKFTDTWTMDQPPGMTVDSINGNCWFLPTKEGLYSTQIKVTDALGAYVVVDFLLQTYTEVGKCDPTCSNADASCTSNSQCTKCSNTGSNSINTCTNIQSPPEFIIPTPKNGETILFPIDKSSEFYLSCKTPYASRTASITTSSIPTELALTTTSTGQTNSIKYSWSPKTSSIGSYVISALCKDSSGLTSEVRSFTIRIEKPECGNGGIKGGDGKCVCIGNWDTIYQCFECKDGFYGDKCTVLPPCKNGVPNGGVNGDGKCLCNNGWTGSDCSVSNSQSCGSMTSSILSSSNAVSSYLNPIKAQVYLANDKKFDFPLVLSIPSTLSKLDVYLLVDANMNSAATFLNIYNGMDNFISSVKKFAEDTQFGLGIFSDYPSNSITFQPNSNIGSDISSAIREFKPSSYSSSSNGNSLLAATQASSAQVGWNSGSFKVIVIITDIDYQANPTEKSSFTNSLIDKSVVPVVIGFGSPIPNWGASISSNGFGYTVQSAITSGDWSTKAAAGIKAVSSKLVYKSGEMANGKSLVTSLPIGETITQSTQKTVTISLLKPATTNIESPVAKVSVMGYGQTVISINSNRQPTVSNSGFSVDQNSFATFKLTGSDADLNILTFKFTSFLDSTAGIITSSSGVDVSTQTNTFYSSTEVFKFTPKKNYIATSSISFIANDGCVDSTAATITITINRINQAPECQPITINALLNQQVGISLSASDFEDVASKIAIFVSNPSPLTVYGSFNYQDKPITTTTTINNPWQLTFKQIVNPPSAISVGVPFKSRDSASLYSKECLITVNFVHTNEAPISSSLSPVPVNPRDKTTITLTSTDYDSTSATFNIKSFTTGTDGKGTFYICPQLGDCSCTTTQIKLQKNYVSSAVSYSTNIANLGICFSNDQSSQITDYASVTFTSTDNQGLESLPVTVNINVVGTRPNSPPTIISIPKYSVFQDYKDYDKSSKIIDGTDTDQDDYDKSQGVNNLIAVITEKPKKGTLYLKNDGSVASNSPAPMEIYYVPNPGTFGDDTYSYKVIDTLQASSTIATTTVSVIQINHKPSVSADSYSFTSQDVQFEKSLVTSDFDGDQVNCQVIALPNQISMYDSEGILITQVPAKLSKNSYSFRLLDPSLIIPSPFSNVQSQFTVNCLDVTSKTDPFGPLQSDDLIVNVGYIYINTPPKTKTLTVQLDQDTSKAFTFNGDDIETPTSDLKVKIFSLPTNGRLSNQYGYLNGTSISSRTYYLNELTYTPNAGLSNWDTEDNNSPLDKISYAVLDKGGLSSETDLVYFSVRPRNPPIYTGKDEINVLQNTRYPLTIIGEIGNGGSSVAISVVSFTGNGTLYETFNMGSEGTIDRQISSYPVNRSDSLVGSYFYAYKPPHNQYGDDFDTITFVLIDGDLVSKIYTVTVNVIHVNQPPTIKLISYKVLGGSGKEIEFGSNSTVNMNINTMALVKYIGNDIDKDQVGPLGSKVLNIPLTGTIYKFNNETTPLGAIIKDKNLNIERNDDGFYYFVFVPIKGSTGQGYARVPLIVIDDGGLVSPSESVDFNVNNINIPPVITIDKEKRSYSLLTNLTISATKITFDDPDSKNNDVSITISIVGEKDETVVPFSNVSFTVTTGKATCKPDSTLSSITCVGKKSELNKVISKIDIIAKVAGNYRLKVFVDDLGYNSPISIRSSTHLNATDYVTLQISSPEVTTQNSSNKTVLSGAIAGAAAGTALIAAAMWKMLRKAAPPTDAFFDEGAFLGDGVNSNPMYQESKNGGENPLYLASNETL
Protein: PBX homeobox 1 (A0A8I6AJF6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN
Protein: Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A) (D4A8G3)
Organism: Rattus norvegicus (Rat)
Function: Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (By similarity). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96LR2}.
Interaction partners:
- Serine/threonine-protein kinase MRCK alpha
Sequence:
MEGTAESQTPDLRDVEGKVGRKTPEGLLRGLRGECDLGTSGDVLLPGASSTGHGLGDKIMALRMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPERSRRGSWDSLPDTSSTDRLDSVSIGSFLDTVAPRELDEQGHPGPSCPEIDWAKVIPSEDRARTEVDMTSTKLGSLTATWKLPGDGLQCGPPEPSEDDSAKQGFEAHWYWGQCQDDVTFL
Protein: ARF guanine-nucleotide exchange factor 2 (P39993)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in maintaining mitochondrial morphology.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12808035, ECO:0000269|PubMed:14734650}. Membrane {ECO:0000269|PubMed:12808035}; Peripheral membrane protein {ECO:0000269|PubMed:12808035}. Golgi apparatus membrane {ECO:0000269|PubMed:14734650}; Peripheral membrane protein {ECO:0000269|PubMed:12808035}. Note=Soluble and partially membrane-bound (PubMed:12808035, PubMed:14734650). Associates with early and late Golgi compartments (PubMed:14734650). {ECO:0000269|PubMed:12808035, ECO:0000269|PubMed:14734650}.
Interaction partners:
- ADP-ribosylation factor 1
- ADP-ribosylation factor 2
- ADP-ribosylation factor-like protein 1
- ARF guanine-nucleotide exchange factor 1
- ADP-ribosylation factor 3
- ADP-ribosylation factor guanine nucleotide-exchange factor SEC7
- ADP-ribosylation factor GTPase-activating protein GCS1
- Coatomer subunit gamma
- Phospholipid-transporting ATPase DRS2
- GTP-binding protein YPT1
Sequence:
MSDREFVTVDPVTIIIKECINLSTAMRKYSKFTSQSGVAALLGGGSEIFSNQDDYLAHTFNNLNTNKHNDPFLSGFIQLRLMLNKLKNLDNIDSLTILQPFLLIVSTSSISGYITSLALDSLQKFFTLNIINESSQNYIGAHRATVNALTHCRFEGSQQLSDDSVLLKVVFLLRSIVDSPYGDLLSNSIIYDVLQTILSLACNNRRSEVLRNAAQSTMIAVTVKIFSKLKTIEPVNVNQIYINDESYTNDVLKADTIGTNVESKEEGSQEDPIGMKVNNEEAISEDDGIEEEHIHSEKSTNGAEQLDIVQKTTRSNSRIQAYADDNYGLPVVRQYLNLLLSLIAPENELKHSYSTRIFGLELIQTALEISGDRLQLYPRLFTLISDPIFKSILFIIQNTTKLSLLQATLQLFTTLVVILGNNLQLQIELTLTRIFSILLDDGTANNSSSENKNKPSIIKELLIEQISILWTRSPSFFTSTFINFDCNLDRADVSINFLKALTKLALPESALTTTESVPPICLEGLVSLVDDMFDHMKDIDREEFGRQKNEMEILKKRDRKTEFIECTNAFNEKPKKGIPMLIEKGFIASDSDKDIAEFLFNNNNRMNKKTIGLLLCHPDKVSLLNEYIRLFDFSGLRVDEAIRILLTKFRLPGESQQIERIIEAFSSAYCENQDYDPSKISDNAEDDISTVQPDADSVFILSYSIIMLNTDLHNPQVKEHMSFEDYSGNLKGCCNHKDFPFWYLDRIYCSIRDKEIVMPEEHHGNEKWFEDAWNNLISSTTVITEIKKDTQSVMDKLTPLELLNFDRAIFKQVGPSIVSTLFNIYVVASDDHISTRMITSLDKCSYISAFFDFKDLFNDILNSIAKGTTLINSSHDDELSTLAFEYGPMPLVQIKFEDTNTEIPVSTDAVRFGRSFKGQLNTVVFFRIIRRNKDPKIFSKELWLNIVNIILTLYEDLILSPDIFPDLQKRLKLSNLPKPSPEISINKSKESKGLLSTFASYLKGDEEPTEEEIKSSKKAMECIKSSNIAASVFGNESNITADLIKTLLDSAKTEKNADNSRYFEAELLFIIELTIALFLFCKEEKELGKFILQKVFQLSHTKGLTKRTVRRMLTYKILLISLCADQTEYLSKLINDELLKKGDIFTQKFFATNQGKEFLKRLFSLTESEFYRGFLLGNENFWKFLRKVTAMKEQSESIFEYLNESIKTDSNILTNENFMWVLGLLDEISSMGAVGNHWEIEYKKLTESGHKIDKENPYKKSIELSLKSIQLTSHLLEDNNDLRKNEIFAIIQALAHQCINPCKQISEFAVVTLEQTLINKIEIPTNEMESVEELIEGGLLPLLNSSETQEDQKILISSILTIISNVYLHYLKLGKTSNETFLKILSIFNKFVEDSDIEKKLQQLILDKKSIEKGNGSSSHGSAHEQTPESNDVEIEATAPIDDNTDDDNKPKLSDVEKD
Protein: Aurora kinase (EC 2.7.11.1) (C8V088)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Chromosome segregation protein BIR1, putative
- Polo-like kinase
- Nucleoporin NSP1
- Inner centromere protein ARK-binding domain-containing protein
- ATP synthase subunit beta
- Probable kinetochore protein ndc80
- Ubiquitin-conjugating enzyme E2 2
- Kinesin-like protein bimC
- EB1 homolog
- Mitotic spindle checkpoint protein
Sequence:
MATKTLEARFEHLSVKDDSGNGNKGTSYPKHKSSLSTAVSLSGLGVAGQLTSGANRSNLLKLALQNTNDNKVNAMNANASQSPGKGTQNPASLRNLDENGEYEQPAPRKLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLFGHFQDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAHYIAQMASALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLTSNPQGNFYNEKVDLWSLGVLTYEFLVGEAPFEDTPVMTQRRIQRGDMQVPSFVSPEAKDLIKRLLVLDPEKRISLDEIQRHPWILKHCVKDDRTIKRGSGASKDGKV
Protein: Synaptobrevin homolog YKT6 (EC 2.3.1.-) (O15498)
Organism: Homo sapiens (Human)
Function: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
Subcellular location: Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.
Interaction partners:
- Syntaxin-7
- Syntaxin-5
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Golgi SNAP receptor complex member 1
- Vesicle transport through interaction with t-SNAREs homolog 1A
- BET1-like protein
- BET1 homolog
- Golgi SNAP receptor complex member 2
- Vesicle-trafficking protein SEC22b
- Sec1 family domain-containing protein 1
Sequence:
MKLYSLSVLYKGEAKVVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSSKGTRASVKEQDYLCHVYVRNDSLAGVVIADNEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM
Protein: Mite allergen Der f 21.0101 (Allergen Der f 21) (Mite group 21 allergen Der f 21) (allergen Der f 21.0101) (B2GM84)
Organism: Dermatophagoides farinae (American house dust mite)
Interaction partners:
Sequence:
MKFIIFCAIVMAVSVSGFIVDVDTEDKWRNAFDHMLMEEFEEKMDQIEHGLLMLSEQYKELEKTKSKELKEQILRELTIAENYLRGALKFMQQEAKRTDLNMFERYNFETAVSTIEILVKDLAELAKKVKAVKSDD
Protein: Cytochrome P450 family 2 subfamily C member 8 (cDNA FLJ59467, highly similar to Cytochrome P450 2C8) (B7Z1F5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
Protein: Zona pellucida-binding protein 2 (Q6X786)
Organism: Mus musculus (Mouse)
Function: Is implicated in sperm-oocyte interaction during fertilization.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:17664285}. Secreted {ECO:0000250}. Note=Released after the acrosomal reaction. {ECO:0000269|PubMed:17664285}.
Interaction partners:
- Zona pellucida sperm-binding protein 3 receptor
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit theta
- Zona pellucida-binding protein 1
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit alpha
- Heat shock 70 kDa protein 1-like
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit delta
- Heat shock 70 kDa protein 1B
Sequence:
MLAWALLYAVLWSLAGVGSQRSSLFNIKGFVYGTVGHPVKIYVKLHQASPVLICMDIDRANKETVDPTYLWTGPNENTLKGNSQINITNTGELVLKDFLEPLSGLYSCMLSYKTIKAETQEETMIKKKYDFLVFAYREPDYSYHMAVRFTTGSCVGRHNDLLFRVLKKILDNLISDLLCHVIEPSYKCHFVKLPERDFLYELFIAFQVNPFAPGWRSLCNRSADCEDITNHNVLKARDRMEEFFRKQAHILHHHFNRTVPAMHFVDHSFQVTRIDNCRPGFGKNEGLHSNCATCCVVCSPGTFSPDVDVTCQICVSVHIYGAKACP
Protein: Alternative oxidase (EC 1.-.-.-) (A0A1D8PEH5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MLTASLYKQLPVLTTTATSTYSFIRLSSTLATPPHSTTTTSPSSPAFHQPNHPQQFANPNTSVFDVSTRIYTQEGIDNNNDTKFLTKAPYPHPVFPQDECENVIVTHRETKTLGDKISFRSIQFMRQCFDLVTGYAVPKTNNPDEFKGTRWEMTEGKWLTRCIFLESVAGVPGSVAGFLRHLHSLRMLRRDKAWIETLLDEAYNERMHLLTFIKIGKPSWFTRSIIYVGQGVFTNVFFLLYLLNPRYCHRFVGYLEEEAVRTYSHLLDELAVPGKLPAFETMKIPEVAVQYWPELTPKSSFKDLILRIRADEAKHREVNHTFANLEQKTDRNPFALKIEGLNKPQPNHGINVMRPTGWEKQDLQL
Protein: GTP:AMP phosphotransferase, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Q5BGS1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|HAMAP-Rule:MF_03169}.
Interaction partners:
- Ribonucleoside-diphosphate reductase
- Nucleoside diphosphate kinase
- Ribonucleotide reductase
- adenine phosphoribosyltransferase
- Adenylosuccinate lyase
- Adenosine kinase
- Adenylate kinase isoenzyme 6 homolog
- Phosphodiesterase
- AMP deaminase
- Pyruvate kinase
Sequence:
MTLTTRQLKKAARIILIGAPGVGKGTQTERLLSKFPELASISSGDLLRENVRRRTALGREAEATIQAGNLVPDSMILNLISSEFNSRGWLSKSQSSGSSVSPSASFILDGFPRTASQAASLDSLVPINFVVHLVTPPSIILSRIASRWVHEPSGRVYNTDFNAPKVPGKDDVTGEPLTQREDDSIETWKQRLHKFEETSKALLQHYQQKGCLWRVEGNSSDEITPKLLAEFERKFC
Protein: X-box-binding protein 1 (A7SXY9)
Organism: Nematostella vectensis (Starlet sea anemone)
Interaction partners:
- Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop domain-containing protein
- Uncharacterized protein
- WD repeat-containing protein 18
- Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein
Sequence:
MTSYSFPDVGPTFSSPRSFRDTSWSRDCPEILLKTPCIGMLDIPLVNLGLADHTYCLPPSAITLEVFAKLQAKAMENGELLRWEDASIAFEPPNSDQESKSSCSSLSPAHSVDSGFDAGMESLLADFLGGEGSSPDLNLDLLLNEPTTFTEPKAPTAILTKPKPSPFNEPLTEEELKDIEDKNKKNAIAARENRAKKKKYMEDLEKTVQDLKKENQELQTGHSKLQKTVEALNDEVSYYKNVLANQSTLSLLLNRIATTPGINFGTSFGKDAGGCSQGEKRREVVEVNTNQQSSSAAMVTVEDEGISHRYHTRRARKRPAETGTSSNIAVKHRPKATSGGICLHVSQDKVSLEMCQHCSAKALGIVE
Protein: Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase R) (CPR) (Carboxypeptidase U) (CPU) (Thrombin-activable fibrinolysis inhibitor) (TAFI) (Q9EQV9)
Organism: Rattus norvegicus (Rat)
Function: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
Subcellular location: Secreted.
Interaction partners:
- Prothrombin
- Carboxypeptidase B
- Plasminogen
- Heparin cofactor 2
- Vitamin K-dependent protein C
- Antithrombin-III
- Thrombomodulin
- Carboxypeptidase N catalytic chain
- Complement component C8 beta chain
- Serpin family F member 2
Sequence:
MKLYGLGVLVAIILYEKHGLAFQSGHVLSALPRTSRQVQLLQNLTTTYEVVLWQPVTAEFIEKKKEVHFFVNASDVNSVKAYLNASRIPFNVLMNNVEDLIQQQTSNDTVSPRASSSYYEQYHSLNEIYSWIEVITEQHPDMLQKIYIGSSYEKYPLYVLKVSGKEHRVKNAIWIDCGIHAREWISPAFCLWFIGYVTQFHGKENTYTRLLRHVDFYIMPVMNVDGYDYTWKKNRMWRKNRSVHMNNRCVGTDLNRNFASKHWCEKGASSFSCSETYCGLYPESEPEVKAVADFLRRNINHIKAYISMHSYSQQILFPYSYNRSKSKDHEELSLVASEAVRAIESINKNTRYTHGSGSESLYLAPGGSDDWIYDLGIKYSFTIELRDTGRYGFLLPERFIKPTCAEALAAVSKIAWHVIRNS
Protein: Deoxymugineic acid synthase 1 (ZmDMAS1) (EC 1.1.1.285) (B4F9A4)
Organism: Zea mays (Maize)
Function: Catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. Involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron.
Interaction partners:
- Nicotianamine synthase
- Iron-phytosiderophore transporter yellow stripe 1
- Pyridoxal phosphate
Sequence:
MSATGRAPCGLPRIGLGTAVQGPRPDPVRAAVLRAIQLGYRHFDTAAHYATEAPIGEAAAEAVRTGLVASREDLFVTSKVWCADAHRDRVLPALRRTLSNLQMEYVDLYMVHWPVTMKAGRFTAPFTPEDFEPFDMRAVWEAMEECHRLGLAKAIGVCNFSCKKLETLLSFATIPPVVNQVEINPVWQQRKLREFCRAKGIQLCAYSPLGAKGTHWGSDSVMDSGVLHEIAKSKGKTVAQVCLRWVYEQGDCLIVKSFDEGRMKENLDIVDWELSEEERQRISKIPQRKINQGRRYVSEHGPYKSFEELWDGEI
Protein: Chemokine-like protein TAFA-5 (M0R7X9)
Organism: Rattus norvegicus (Rat)
Function: Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (By similarity). Acts as a adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling. Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries.
Subcellular location: Secreted {ECO:0000269|PubMed:29453251}.
Interaction partners:
Sequence:
MAPSPRTSSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIKTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS
Protein: Protein CASP (P70403)
Organism: Mus musculus (Mouse)
Function: May be involved in intra-Golgi retrograde transport.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MAANVGSMSQYWKRFDLQQLQRELDAAATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLTVYKRLIDVPDPVPALDVGQQLEIKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQADYEEVKKELNTLKSMEFAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGRCAELQIHLTEATAKAVEQKELIARLEQDLSTIQSIQRPDAEGASEQGLEKIPEPIKEATALFYGPSMSSSGTLPEGQVDSLLSIISSQRERFRTRNQELEAESRMAQHTIQALQSELDSLRADNIKLFEKIKFLQSYPGRGIGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLGLSPWDKATLGMGRLILSNKTARTIGFFYTLFLHCLVFLVLYKLAWSESVERDCAATCAKKFADHLHKFHESDNGAAAGDLWQ
Protein: Sigma-54 activator protein ActB (Q1D7F8)
Organism: Myxococcus xanthus (strain DK1622)
Interaction partners:
- C-signal regulator ActA
- RNA polymerase sigma-54 factor
Sequence:
MDRIAVLVVDDEEAVRTFLSELLGSAGYQVRCAASGTQALEMLSGGSFDAVLLDVVMPEMSGLEVLRRYQSMGGGAPVIVLSALAGADDAVRAMKMGASDYLAKPFGNDELQDALARALGTRAPERQAVAPILPSRTVLPVVDSAQEQRVLISTSPAMRRARALVERIADTDVPVLLLGESGTGKEVIAREIHARSQRRNRPFIKVNCAALPGELLESELFGHERGAFTGATAEKPGKFELADQGTIFLDEIGEMAIRLQAKLLQVLQDEEFFRVGGKKSVRVDSRVVVATNRDLEKEIALGNFREDLFYRLNVVAIRLPALRERREDVVPLTDHFLKKYGRGYLSGVSELPTEVLHAFADYDWPGNVRELENMVRRLCVLKDPTLVLDELRAAVRAPASAPSLPTSYAGDDGGPFGRAHDEGFRTPPPAVQVLEMPSRGAAFGLASVAPLAPPAHAPMVMESANAVVSAPRYVNPFDVPQPPPPPAPTGELSLKDIGKRAAMLAEREAILAMLQRTAWNKRRAATKLRISYKALLYKIKECGIIDPRASAEL
Protein: DUF4201 domain-containing protein (Q57XL0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTTALSSAKNARSPGSNAAVSPGSKLASLREGASTGVAKDEAESAALGGLAGGDAEGLAAGAMSGLAETATEAAADELGDAASEDQANFFSEKLVEVIPQCNEIEGERDLNGELLGEEAPRTDEGDVNNVGCSSAAESLPQEEVEETEEQIIIRLQKELREFEAYEKEMQPNLNIYEDIIELRREAEQLEDDRKRALLQIDLGDISSYYDGDVEREVEELEAAVENSYLQACWTKERQRYIARNETDLPEWWRVNVKDLPSRLKDARASFDSSNRVAQDLYRAHEVKVNATTDSRDKAKAEIFNGMKAEIEATKGERERLRQLQKDQLFHLRRGTHVKDQLLTTTKERDIREARVADMESKLVQQRYALNNEMKELNGDIEGLKRLLTDQKHASRETLETLKKQHVAVDSSRGELSEAREKYERENSELMLLKHDLQTVLHYIRVRAREADK
Protein: Glucose-6-phosphate exchanger SLC37A4a (Solute carrier family 37 (Glucose-6-phosphate transporter), member 4) (Q6NY67)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MAKTGYGYYRATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTSIFCLIIIRNEPSEVGLPNIEAGAKKGKGGSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAVAKHGLRLYGNPRHGLLLSMMAGMCVSMYLFRTTVTAHSSNVWILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVTTVGYFLLRNIRTKMGSIPKKAD
Protein: Metadherin (H0YBJ8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
TNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETS
Protein: Cilia- and flagella-associated protein 251 (Flagellar-associated protein 251) (A8IRK7)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: As component of a spoke-associated complex, regulates flagellar dynein activity by mediating regulatory signals between the radial spokes and dynein arms.
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:17967944}.
Interaction partners:
Sequence:
MAEEQTALSLSWVFGASAHVKHGVVNLSDGYTDKICYLAANTAVIYDKRLRRQLFLQGHTSPITCIVTTEDRSHVVTADTGPEALLVVWNVRTGLPTRTVQQPHRHGVSTMDMSADGQWLATVSAADPESGEQEVSLWSMAALLTPPEAAPPGQGPLRPLVTTLVPAGDVQHSIRFSPNNPAELISNGRRRVYFWSWAPGSPRFQYYSPPLRSRDFKQSVGDFVSSVFVPGTTQALTATTDGDLVVWDEQGIAAQVGTSATDRRAIKLMRIHNCPITLLATVGDFIVSGGEDGYVRFFDPLLRIVAWFEDLAAGPVTSVAFSAVLPDRLAHADAADTLNRFMVPDFVVATRNSRIVSVQSASFEEYDADRRRGSSVLDSLLADVVDLAAHPTRAEFAVLGRDGGLQRWDSIAHCLLGGRAFERQVGACLTYSRDGSLLVVGFGSGHLHILNADDCSDLYVMRNTAAGLVRVAVSNTGKHIAAADENHQLLLYAYLPYKHTMRWEYVGRCRSHHGPIASVVFGESPSGQTRLLSVGGDGRVVEYDLAASSVAAGVQVASFYDFPPGGGAPTSLSFAPPLAYFQAFAADTHLLVSGADGTVASWDINTAPLERSATAAEGAGGEARWAAVLGDPDLLREMRDYFVYAQIKTQGEDALEPRDVPGTVPVDLVPDLMRSAGFYPSESDIDNLLHHVQYMAHSRNMESLEVVTLADLLCLYINHRPLFNVTHADIVAAFRELGGRGDPGSCVPKLSREQLLSLLQSTGEPMSGEELTAALAALTGAHTPEKSMPVSVAAEQFSADVLGFDTTEAGAEAAT
Protein: SBDS-like protein (C0J347)
Organism: Trypanosoma cruzi
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSARIQVPLSQRRHTNVAVVRYTKNGVRLEIACYKNKVISYRGGIETRMDEVLQVERVFTNVSRGLYSSEKEIEAVFGKGTSEKEALQYILDHGELQVAQQERAAEIDQMFIDIAVIISQKCVNEVTQRPFPSQVIEQALHSIGAAVKLDQPVKKQALAFIHQLIDAKTIPIARARMKLRCVVPDEPSLEKLVEWCETNGTSILQKVVEAGGSDAALQIHSLLILLQPHLFRDIERFVKTEMPPGGSVHVIENAAMDVGEGDVMDAELIARANAHMTGASGVGNADKSHCTGSSSNPHAESNRGRRKGKGGSRKPQGVQRVLGKDDGTDQQTVTTAELSSTPAVVGENDDELKVALSKLVLDETNGSRDEDYDGKGRRGKKKAKRRQGEPHQKQQQQPATPQKTVEVDEQQGSDEEVLVNRKQRKQAAARVRVKDDKRNEYWNDADDDDYDYGYEDEDAGEVRD
Protein: DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) (Q03267)
Organism: Mus musculus (Mouse)
Function: Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells (By similarity). Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10970879, ECO:0000269|PubMed:12464629, ECO:0000269|PubMed:18223295, ECO:0000269|PubMed:19282287}. Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events.; SUBCELLULAR LOCATION: [Isoform V]: Nucleus. Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events.; SUBCELLULAR LOCATION: [Isoform I]: Cytoplasm.
Interaction partners:
- Protein cereblon
- Histone deacetylase 1
- Paired amphipathic helix protein Sin3a
- Erythroid transcription factor
- Chromodomain-helicase-DNA-binding protein 4
- Paired box protein Pax-5
- Histone deacetylase 2
- Transcription factor PU.1
- DNA damage-binding protein 1
- Runt-related transcription factor 1
Sequence:
MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTTSGAQQNSKSDRGMGSNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIVCIGPNVLMVHKRSHTERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGVCPVIKEETNHNEMAEDLCKIGAERSLVLDRLASNVAKRKSSMPQKFLGDKCLSDMPYDSANYEKEDMMTSHVMDQAINNAINYLGAESLRPLVQTPPGSSEVVPVISSMYQLHKPPSDGPPRSNHSAQDAVDNLLLLSKAKSVSSEREASPSNSCQDSTDTESNAEEQRSGLIYLTNHINPHARNGLALKEEQRAYEVLRAASENSQDAFRVVSTSGEQLKVYKCEHCRVLFLDHVMYTIHMGCHGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRYHLS