wanglab/gogpt-training-data huggingface dataset:
Protein: V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (P39) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (Vacuolar proton pump subunit d 1) (P61420)
Organism: Bos taurus (Bovine)
Function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P61421}; Peripheral membrane protein {ECO:0000250|UniProtKB:P61421}; Cytoplasmic side {ECO:0000250|UniProtKB:P61421}. Lysosome membrane {ECO:0000250|UniProtKB:P61421}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32764564}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250|UniProtKB:Q6PGV1}.
Interaction partners:
- Ribonuclease kappa
- V-type proton ATPase 116 kDa subunit a 1
- V-type proton ATPase subunit B, brain isoform
- Renin receptor
- V-type proton ATPase subunit F
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit D
- V-type proton ATPase subunit C 1
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit H
Sequence:
MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF
Protein: phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Q6XPX3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- GXIVsPLA2, isoform A
- phospholipase A2
- phospholipase A2
- Phospholipase A2
- Phospholipase A2
- Phospholipase A2
- GH11618p
- FI05338p
- Phosphatidylserine decarboxylase proenzyme, mitochondrial
- FI14826p
Sequence:
MWLLREAFFFGLLAMAWAFGDEAIFEDEDIYNQALPPVPHTGITVPGTKWCGPGNTAANFEDLGRERETDKCCRAHDHCDEIIESHGALHGLPTNTDWFPILKCTCEQQFINCLQAVNSITAKTLGRIYYGSRSRCFANGHPTTGCKQYQEGTFRKRCIRYQVDKSKAKVWQFYDMPFFTIPASAG
Protein: Pluviatolide synthase (EC 1.14.19.72) (Cytochrome P450 family 719 subfamily A polypeptide 23) (L7T720)
Organism: Podophyllum peltatum (American mandrake)
Function: Cytochrome P450 involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family. Catalyzes the conversion of matairesinol to pluviatolide.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEMETSVLGLSSTLIIALAITVIFLLKAKSSSAIKWPPGPKTLPIIGNLHQLGGDELHIVLAKLARVHGAIMTIWMAKKPVIVVSDVNSVWEVLVSKSSDYAARDAAEISKIVSASSHSINTSDSGPYWQTLRRGLTHGPLGPLNISAQIPIQQRDMQRVIREMQQDAAANGGVIKPLDHLKRSSTRLVSRLIFGDTFDNDPYNDSMHEVVQDLNRFGGIALLEQAFSFAKYLPSYKRGVKEFHIHKRKIDDLVRPVVASSNPPSNSYLGFLQSQNYSEEIIIACIFELYLLAMDSSASTATWALAFMIRDQQVQEKLYQDIKRVIGDEVGLVKAEDLSKMHYLQAVVKETMRMKPIAPLAIPHKTAIDTSLMGTKVPKGTCVMVNLYALHHDESVWAKPYTFMPERFLQREDGKSVTEQAFLPFGAGMRICGGMEVGKLQFSLALANLVNAFKWTSAAEGKLPDMSDELQFITVMKTPLEARIVPRNP
Protein: Vitellogenin-6 (P18948)
Organism: Caenorhabditis elegans
Function: Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). May play a role in cholesterol uptake. May be involved in thermotolerance.
Subcellular location: Secreted.
Interaction partners:
- Vitellogenin-5
- Vitellogenin-2
- Vitellogenin-4
- Uterine Lumin Expressed/locailized
- Vitellogenin-1
- EGF-like domain-containing protein
- DUF1525 domain-containing protein
- Microsomal triglyceride transfer protein homolog
- Uterine Lumin Expressed/locailized
- UPF0375 protein ule-4
Sequence:
MKFFIALALLGAALASTHLDRYNSIERNIQESSFRAGREYRYLFNGQLSAGLPVPSTPQGISRLQSQVTLQWTDGNTVRMQLQKTRFATSQQESNSMKMLPFERFEEVERMNREHQELLSMPVEFDYEHGLVREIRFAENDQPWSENIKRAVINMLQVNILKKEKYEGAEKSDNQEPTFSFTNVERTLEGECEVLYTVEEIKKEDEQRWAKSINFDKCTRRPYIHHVQTPVCKDCQQTLEQDKMSSTVLNYNITGTSSSFLINSVELRSQHLFAPISEKHQLVSAFTLNTMELIYAGEKKTEIKQVRNEKTSELVYNQESEWAEQQWAQTGEEKYLRQLPQWTENKVEMIKKMFSLMAKQIEQGEAELEAAHTVARIVKVLRECNEEQLEQIYRHVAEHKDEKIAEQLRSIYFNTLALAGTRVTIQQFVDKVQSRKNIAPLKASVAIKTLVDMRYPSLAIAEDIARLCESDVSSSFPALRQSCWLTYGAIVNGVCGQTPRVFVQKNGVKMCPRDAKQRIVDKLVQQFESASTRYEKVLALKTLANAGLDLSVYPLEKIILNEQHETTIRTQAIESFRRLRTQMPTKIQRVLMPVYLNRQQPQHIRMSALHQIIYTQPEWSVLSQIGNQLRQERNQQVRAFTLSLLRSYANNESPCEQTFSSRVQSLLNNIPFSSQEIDRFESVYGKWSTYSRRHQSGFEANFASLFTTESVLPTEMMASIEGVLSGEWNQYFAQIGFTQKNMEKIIKKLLSNVQEKGLEQIVVRGKRASGSFQPTEFLSNLLEKLRITRRQSSEQDPHAFVYIRHRDMDYAFLPIDADSIPEVVRSMIQGGRLEIGDIERVLAQGIHFSASNAAFLYETVRRVPTPMGLPVQFTSKMPTISSIRGQVTFELEPKNGKSFDGLRLRVQAGPRVASTHVLSLRVICPIAEVGTKFLHQAVLNTPVDTEIRMNWEDKVVIRAIYNTPSEEKRIAMIQSRPVTFTRTVAPDARQYPEPIEMTYMLPAHKQLSQSLDREYPQIRVQGTLNRPTSVRIPQWIVDSNVEVYYKPNVEQYEAIFELNLYNNYKMEKNYEKVYKKHNGRRYLEAEPEYDEEEHREQITKKFEWLQNEKVYQHVAKFEIKPEVVKMEVEAVCNNDFHFCKTQIRGEELKATIQYVYPQTPRTVEELKEQKYRQLVVMGEMNYGENTIHININGQQSQEQKKFVKQIEQAPEHETLLEASRLDQYQTVVEYEFEPKPAQYFARYWNMVQAYLRTQYPWTSRIETREEPSRKNMIRATINVEPRQRLTVNMTIETPMETTVLERVELPFRLPTAQIHYQPRNSRYEQKPVMEKIAHHASKQANCVVKSTKINTFDQVAYRNQFTPCYSVLAKDCGSEKSEPRFVVLMKKINEKKEWKNVKVVYGENEIEMYKTEEGLICRVNGEEIEYQPESEIEKKQYNIIWLNKNTLKFDSDDVTVQFDGVNARIHLSALYRNQQCGLCGHYDNEKETEFYDAENQENTIPKFAKSYLYKDSKCNYEREMFEKEENFQRIEKNQEEEKDQEMNYEESRREQDDEPTEQVAIVERQHEICFTQKPVLRCQNGKSQESKKQKVTSVYCLPSSNSWARRQMREIRREPLAQWPEHKLRNLRDQPQMEERTVRVAVDQKCDKFDY
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (A0A1D8PCA8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Calcineurin subunit B
- FK506-binding protein 1
- Rcn1p
- Calmodulin
- Mlc1p
- Calcium-binding protein NCS-1
- Protein phosphatase 2A structural subunit
- Protein phosphatase PP2A regulatory subunit B
- Uncharacterized protein
- Mlc2p
Sequence:
MSGNTVQRNTEQINNALNAIQHRRTTTGNESNTNTNQRQILQNPTGRDYTIYVTDDGEKYSTVERAVKSVDPPATFKPKDEQVFYPNGKPNHQFLKQHFIHEGRLHEHQAIQILKQATHLLSKEPNLLSVPAPVTICGDVHGQYYDLMKLFEVGGDPASTKYLFLGDYVDRGSFSIECLLYLYSLKINYPDTFWMLRGNHECRHLTEYFTFKNECLHKYSEELYEECLVSFNALPLAAIMNEQFFCVHGGLSPQLTSLDSLRKLHRFREPPTKGLMCDLLWADPIEEYDDDNLDQEYVTNVVRGCSFAFTYKAACKFLDRTKLLSVIRAHEAQNAGYRMYKRTKTMGFPSLLTMFSAPNYLDSYNNKAAVLKYENNVMNIRQFNASPHPYWLPHFMDVFTWSLPFVGEKVTDMLVSILNVCTEEELDEDLPFSEAEIGVTPTTTTTGATPVSPKAYPPSSRITSPHKSTKLVESRANEEEKSNDGDDDSEMTLEEKKQALRNKIIAIGKMSRMFQVLREEQENVAHLKELNRGSLPKGSLLHGADGLKNTINSFEEAKAADRVNEALPPSPEDLQRLKQEKNTRIRQQIENQEMSGPVFQRLIRRLSQS
Protein: Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Dopamine receptor-regulating factor) (Transcription factor BTEB4) (P58334)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds GC and GT boxes in the D1A, D2 and D3 dopamine receptor promoters and displaces Sp1 and Sp3 from these sequences. It modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MSAAVACVDYFAADVLMAISSGAVVHRGRPGPEGAGPAAGLDVRATRREATPPGTPGAPPPPATAPGPGGATAAPHLLAASILADLRGGPVVATAASTAGGTSPVSSSSAASSPSSGRAPGAAKSHRCPFHGCAKAYYKSSHLKSHLRTHTGERPFACDWPGCDKKFARSDELARHHRTHTGEKRFPCPLCTKRFTRSDHLTKHARRHPGFRPELLRRPGARSVSPSDSLPCSLAGSPTPSPVPSPAPAGL
Protein: Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) (Q6QMG1)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Function: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P16473}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P16473}. Basolateral cell membrane {ECO:0000250|UniProtKB:P16473}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P16473}.
Interaction partners:
- Thyrotropin subunit beta
- Glycoprotein hormones alpha chain
- Gonadotropin subunit beta-1
Sequence:
MRLFALVLIFFFSTRTCTEDVKSCPNGCECTDWKGYYVSCTDIATLPIFPGNTETLRLYETRLSSVPQDAFVNMVNISLIYLSVDVTLRSLEKHSFFNLKKITHVEIRNTRSLMSIDPEAFKDLPELKYLGLFNTGLTIFPALTRIHSHESNFMLEITDNLYITEIPANAFQGITKDALTVMLYSNGFTKIQHHAFNGTKLDAIYLHRNKELTELSEDMFAETISGPVLLDVSDSGVTSLPATGLESLRELSARNVWALKKLPSVKTFRHLIGADMTYPSHCCAFKNLKKKKGYLDYIICNLTAMRGQHYERSVGRITVPAVMDGTDKGIDISDPLLGNTYDHHDFLRSLHYHEFLGGHADYDMGFGDTLKNPQIATSQDFDSHYDYVVCEDGEAVTCAPAPDDFNPCEDIMGFSFLRVSVWFVSLLAVLGNMVVLFVLLTSHYKLSVSRFLMCHLAIADLCMGIYLLLIASVDLYTQSEYYNHAIDWQTGPWCTLAGFISIFATELSVYTLTTITLERWHAINFAMQLDRKLRLSHASAVMLGGWLLCLLLALMPVLGVSSYQKVSICLPMSTQNLLDQVYILFILVINIVAFVAICACYIKIYCAVHNPNYTSSRKDSSIAKRMAVLIFTNFLCIAPISFYAISAALDHPLITISNSKILLVLFYPLNSCANPFLYAIFTKAFQGDVFILLSKIGLCEQQAKLFRGQTISTRASSGDTNRRGIKTKILTRWNVQATATCHQSSVNKDNNTSRGRKCEPTANKSKHIQGMNSTMVFY
Protein: Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) (Q923Y8)
Organism: Mus musculus (Mouse)
Function: Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Subcellular location: Endomembrane system {ECO:0000250|UniProtKB:Q96RJ0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96RJ0}; Multi-pass membrane protein {ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465}. Cell membrane {ECO:0000269|PubMed:37225986}; Multi-pass membrane protein {ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465}. Note=Localizes mainly intracellularly. Partially colocalizes with the endoplasmic reticulum; also found at lower lever at the plasma membrane. {ECO:0000250|UniProtKB:Q96RJ0}.
Interaction partners:
Sequence:
MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
Protein: VQ motif-containing protein (Q9M1D4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g32610
- VQ motif-containing protein
- VQ motif-containing protein
- At5g65170
- F16F4.1 protein
- VQ motif-containing protein 5
- VQ motif-containing protein
- VQ motif-containing protein 19
- VQ motif-containing protein 13
- At5g46780
Sequence:
MVRNSMKAEYDIDHLPHQTFYGDYSKTLVPMNKNSQIITKIKPKIRIIHIFAPEIINTDVKNFRTLVQSLTGKPEITKTGSKKKITNTNFPAPPGLPQDSGQEHTAELDNRIIGSHVVKEEWGSSSNTNTYFDFDGLIDLDEDDNIFSSRWFDLQQQ
Protein: Epsin-2 (EPS-15-interacting protein 2) (Q9Z1Z3)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in the formation of clathrin-coated invaginations and endocytosis.
Subcellular location: Cytoplasm {ECO:0000250}. Note=In punctate structures throughout the cell and particularly concentrated in the region of the Golgi complex. {ECO:0000250}.
Interaction partners:
- Clathrin heavy chain 1
- Epidermal growth factor receptor pathway substrate 15
- Clathrin light chain B
- Epidermal growth factor receptor substrate 15-like 1
- Clathrin light chain A
- AP2-associated protein kinase 1
- Intersectin-1
- AP-2 complex subunit beta
- Synergin gamma
- Clathrin coat assembly protein AP180
Sequence:
MTTSSIRRQMKNIVNSYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVRFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKVERVQALKTKERMAQVATGVGSNQITFGRGSSQPNLSISHSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRGDDLRLQMALEESRRDTVKVPKKKEVKACCKPGSHSQQTTLLDLMDALPSSGPVAQKTEPWSTGTPANQTNPWGGTVAPANISDPWPSFGTKPAASVDPWGVPTTASIQSVPKNSDPWAASQQPASDAGKTADAWGAAKPSPASGSFELFSNFNGTVKDDFSEFDNLRTSKKPAESGASVPPQDSRTTSPDLFESQSLTSASSKPSSARKTPESFLGPNAALVNLDSLVTKPAPPAQSLNPFLAPGAAAPAPVNPFQVNQPQPLTLNQLRGSPVLGSSASFGSGPGVETVAPMPSVAPHSALGATGSSLTPLGPTAMNMVGSMGIPPSAAQPAGTTNPFLL
Protein: BCL2-binding component 3 (Bcl-2-binding component 3 isoform X1) (F1QKA1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Noxa
Sequence:
MARPEMESRVDEHNSGTPNSCRMEVLRQDAWPNGSIIQPCHRRRTIATQTSTLSAPLPHIPSHDAFSLDSVQQQDSLLRDNSGTEQEVSRPLPLPDLLADNQSSSEESTSSSSSTAEEDPTLEEQAVERVAVQLRTIGDEMNAVFLQRNAVPHWQNWRGLYRGLMALVSDTINALYQHGLR
Protein: Cholesterol transporter ABCA5 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 5) (Q8CF82)
Organism: Rattus norvegicus (Rat)
Function: Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:16162093}; Multi-pass membrane protein {ECO:0000269|PubMed:16162093}. Late endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000269|PubMed:16162093}; Multi-pass membrane protein {ECO:0000269|PubMed:16162093}. Cell membrane {ECO:0000250|UniProtKB:Q8K448}. Note=Localized at cell membrane under high cholesterol levels. {ECO:0000250|UniProtKB:Q8K448}.
Interaction partners:
Sequence:
MATAIRDVGVWRQTRTLLLKNYLVKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVSDIELSPMDKSILSNLILGYTPVTNTTSSVMQRVSTDHLPDVLVTEEYASEKELLASSLSKPSNFVGVVFKDVMSYELRFFPDMVPVSSVYMDSRAGCSKSCDAAQYWSSGFTALQASIDAAIIQLKTNVSLWRELESTKAVIMGEAAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKRLKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASSLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGVVEFFVTVVFGFVGLLIVLVESFPRSLVWLFSPLCQCAFLIGIAQVMHLEDFNEGALFSSLTEGPYPLIITLTMLALDSVFYALLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKNKRNYKELSEGNINGNISLNEIVEPVSSEFIGKEAIRISGIQKAYRKKNETVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQSDMNFDVLTVEENLSILASVKGIPANNIIQEVQKVLLDLDMQAIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATESLSSLVRQHIPAAALLQQNDQQIVYSLPFKDMDKFSGLFSALDIHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPREEETDSKSFDEMEQSLLILSETKASLVSTMSLWKQQVSTIAKFHFLSLKRESKSVRSVLLLLLIFFAVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSTDSDINDLIDFFTQQNIIVAMFNDSDYVSAAPHSAALNVVQSEKDYVFTAVFNSTMVYSLPVMMNIISNYYLYHLNVTDTIQIWSTPFIQEITDIVFKVELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFVVLTLMLGSLFAFHHGLYFYPVKFLAVVFCLIAYVPSVILFTYIASFTFKKILNTKEFWSFIYSVTALACVAVTEITFFLGYGVTAVFHYTFCIAIPIYPLLGCLISFIKGSWKNIPKTENAYNPWDRLLVAVIMPYLQCVLWIFLLQHYEKKHGGRSIRKDPLFRALSQKAKHKKFPEPPINEDEDEDVKAERLKVKELMGCQCCEEKPAIMVYNLHKEYDDKKDFLHSRKTTKVATKYVSFCVKKGEILGLLGPNGAGKSTIINILVGDVEPTSGKIFLGDYGSHSNEDDESTKCMGYCPQTNPLWPDITLQEHFEIYGAVKGMSSGDMKEVISRITKALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEIDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFAKLEEAKHTFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWERRQEDRVVF
Protein: Synaptosomal-associated protein 25-A (SNAP-25A) (Synaptosome-associated protein 25.1) (SNAP-25.1) (Q5TZ66)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
Subcellular location: Synapse, synaptosome {ECO:0000250|UniProtKB:P36977, ECO:0000250|UniProtKB:P60880}. Cell membrane {ECO:0000250|UniProtKB:P60881}. Note=Complexed with macromolecular elements of the nerve terminal. {ECO:0000250|UniProtKB:P36977, ECO:0000250|UniProtKB:P60880}.
Interaction partners:
- Vesicle-associated membrane protein 2
- Syntaxin 1A
- Synaptotagmin
- VAMP/synaptobrevin
- Secretagogin
- Syntaxin 1B
- Vesicle-associated membrane protein 3
- Syntaxin-binding protein 1a
- Vesicle-fusing ATPase
- Synapsin-1
Sequence:
MAEDSDMRNELADMQQRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKDAEKNLNDLGKFCGLCSCPCNKMKSGASKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTDDARENEMDENLEQVGGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
Protein: Kinesin-like protein (G5ED75)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MLVVGMHVEIKRSDGRIHGAVIAEVKSNGRFMVEWYEKGETKGKESSLEELLTLNPSLQAPKPTPPPQPPQKTLQASTAVNRQNGIHAQSMILDDEDTFLLDHINMIPAKGASANKRPTGAFTQHVPVRMAPPSEKPLPTRRAPSPKEDAAPAPKSTRTTAAFKPDLDSTAITVPKHTARRTVVVAPAPAPVPAPPIANMTSQRAPSPVARVPSPKNVPRSYPQQDVQPSNGNFAFAEMIRNYRAQIDYRPLSMFDGVNENRISVCVRKRPLNKKELTKAEVDVITIPSRDITILHQPQTRVDLTKYLDNQKFRFDYSFDEYANNELVYRFTAAPLVKTVFDNGTATCFAYGQTGSGKTHTMGGDFSGKKQNASMGIYALTARDVFRMLEQPQYRRKDLSVHCAFFEIYGTKTYDLLNDKAELRVLEDKMQKVQVVGLKEEQAHNEQDVLELINKGTLVRTAGTTSANANSSRSHAIFQIILRQGKKVWGKFSLIDLAGNERGQDTRECDRDTRKEGANINTSLLALKECIRGMARNSSHVPFRQSKLTMVLRDSFIGEKSRTVMISMISPGISSSDHTLNTLRYADRVKEMGTDGSGEATPIRDEELFLPPSADKSDEEYDEMVEKQEHRRVAVDHVRNLKDMSEKIIRETTIVLSNEPSAAQKAECLAKLDQLAQIVSNTRVAVENV
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A8I5ZL09)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRVRPLSSPPPPKPLPLLSLSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEDEKRRVEREQEYIRRQLEEEQRHLEILQQQLLQEQAMLLHDHRRPHAQQPPPPQQQDRSKPSYHAPEPKPHYDPADRAREVEDRFRKTNHSSPEAQAKQTGRGLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCPPSRSEGLSQSSDSKSEVPEPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAAKKPEDKKEVFRPLKPADLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEEEDVEQEGADDSTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQSTVDQKRASHHESNGFAGRIHLLPDLLQQSHSSSTSSTSSSPSSSQPTPTMSPQTPQDKLTANETQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGLRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCTIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
Protein: Evasin P1172 (V5I2G9)
Organism: Ixodes ricinus (Common tick) (Acarus ricinus)
Function: Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL5 and CXCL8.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
FLLKSQLCYCLFGIELIGAGIHALHEDEIFTVDYCGTNCTKQSNGSWTTCPGNCSCYHEDGKTDGFCLSTEYTDFTQFPNLTSEEMDAATPRPE
Protein: Creb1 protein (Cyclic AMP-responsive element-binding protein 1a) (cAMP responsive element binding protein 1) (cAMP-responsive element-binding protein 1a) (Q803K8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- histone acetyltransferase
- Cyclic AMP-responsive element-binding protein 3-like protein 2
- Cyclic AMP-responsive element-binding protein 3-like protein 3-A isoform X1
- Cyclic AMP-responsive element-binding protein 3-like protein 3-B
- cAMP-responsive element-binding protein 3-like 3 like.
- Cyclic AMP-responsive element-binding protein 5
- Cyclic AMP-dependent transcription factor ATF-4
- CREB-binding protein b.
- Ribosomal protein S6 kinase
- Cyclic AMP-dependent transcription factor ATF-4
Sequence:
MTMEAGADVQQGGDTAVSETDTQQIATLAQVSMAAAQASATAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESDDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPAVPRIEEEKSEEDSTPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAGAQPGTTILQYAQTSDGQQILVPSNQVVVQAASGDVQAYQIRTAAASTIAPGVVMASSPALPSQGAEEATRKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSE
Protein: Probable transcriptional regulator (Q9I551)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable transcriptional regulator
- Transcriptional regulator
- Uncharacterized protein
Sequence:
MELKDRIKAARKHAHLSQVQLAQAVGMTQTSISDLERGKSRATSFVAQIAGACGVNPLWLAEGRGEMLAERGQANAGPNASWLGAVESWDDETPLDADEIELPFYKEIELSGGKGSTVILQTGGRKLRFGKYTLRKKNIDPASAACVTVSGNSMEPVLPDGSTVGVDTSARTIKDGDMYAFDHDGQLRVKLLYRLPGGGLRIRSFNSDEHPDERYEPQEAAEHINVIGRVFWYSVLV
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit) (Q9CQH3)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000250|UniProtKB:O43674}; Matrix side {ECO:0000250|UniProtKB:O43674}.
Interaction partners:
- NADH dehydrogenase flavoprotein 3, mitochondrial
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 4
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 5
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
Sequence:
MAAMSLLQRASVSALTALSCRRAGPRLGVGSFLTRSFPKTVAPVRHSGDHGKRLFVVKPSLYYDARFLRLMKFYLMLTGIPVIIGITLVNIFIGEAELAEIPEGYIPEHWEYYKHPISRWIARNFYDGPEKNYEKTLAILQIESEKAELRLKEQEVRRLMRARGDGPWYQFPTPEKEFIDHSPKATPDN