wanglab/gogpt-training-data huggingface dataset:
Protein: Receptor tyrosine kinase (Q9VIE4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MESTTIVFVTLLTIITQRKHCAAVDVYFPTTSVKFNLPINEESESIFSKIPLAQFQVLRMEDNRLASDYLYSLEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTAFPRDQPDHELLNVSHLSLEVTPQPLEEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSL
Protein: Receptor activity-modifying protein 3 (Q9JJ73)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O60896}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60896}. Membrane {ECO:0000250|UniProtKB:O60896}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60896}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner. {ECO:0000250|UniProtKB:O60896}.
Interaction partners:
- Calcitonin gene-related peptide type 1 receptor
- Pro-adrenomedullin
- Calcitonin receptor
- Protein ADM2
- Islet amyloid polypeptide
- Receptor activity-modifying protein 2
- Calcitonin gene-related peptide 2
- Receptor activity-modifying protein 1
- Neuroendocrine secretory protein 55
- Gamma-aminobutyric acid type B receptor subunit 2
Sequence:
MATPAQRLHLLPLLLLLCGECAQVCGCNETGMLERLPRCGKAFAEMMQKVDVWKWCNLSEFIVYYESFTNCTEMETNIVGCYWPNPLAQSFITGIHRQFFSNCTVDRTHWEDPPDEVLIPLIAVPVLLTVAMAGLVVWRSKRTDRLL
Protein: Spectrin beta, non-erythrocytic 2 (A0A5F8MPM8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MNTNGVGRVHGNGLNGAAEFYYEAVEGSQNPGGVLLSPAAFINPAQYASVLEGRFKQLQDEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKH
Protein: Vascular endothelial zinc finger 1 (Q5SXC4)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEANWTAFLFQAHEASHHQQQAAQNSLLPLLSSAVEPPDQKPLLPIPITQKPQAAPETLKDAIGIKKEKPKTSFVCTYCSKAFRDSYHLRRHQSCHTGIKLVSRAKKTPTTVVPLISTIAGDSSRTSLVSTIAGILSTVTTSSSGTNPSSSASTTSMPVPQSVKKPSKPVKKNHACEMCGKAFRDVYHLNRHKLSHSDEKPFECPICNQRFKRKDRMTYHVRSHEGGITKPYTCSVCGKGFSRPDHLSCHVKHVHSTERPFKCQTCTAAFATKDRLRTHMVRHEGKVSCNICGKLLSAAYITSHLKTHGQSQSINCNTCKQGISKTCMSEETSNQKQQQQQQQQQQQQQQQHVTSWPGKQVETLRLWEEAVKARKKEAANLCQTSTAATTPVTLTTPFNITSSVSSGTMSNPVTVAAAMSMRSPVNVSSAVNITSPMNIGHPVTITSPLAMTSPLTLTTPVNLPTPVTAPVNIAHPVTITSPMNLPTPMTLAAPLNIAMRPVESMPFLPQALPTSPPW
Protein: DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) (P49736)
Organism: Homo sapiens (Human)
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:8175912}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250|UniProtKB:P55861}.
Interaction partners:
- DNA replication licensing factor MCM6
- DNA replication factor Cdt1
- Origin recognition complex subunit 2
- DNA replication complex GINS protein PSF3
- Cell division control protein 45 homolog
- Cell division control protein 6 homolog
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM7
- DNA replication complex GINS protein PSF1
- Cell division cycle 7-related protein kinase
Sequence:
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQQF
Protein: BCR1 (G8BGH3)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- HTH APSES-type domain-containing protein
- TEA domain-containing protein
- GATA-type domain-containing protein
- Transcriptional repressor Tup1 N-terminal domain-containing protein
- 40S ribosomal protein S7
Sequence:
MNSIQSPSSPQQQQHSHSQQLPPTQPHLPGINSLPPISAHHYSSHRPFGSSSQSPPQSQHYPQSQRSQINATLPPPPIISSQQHYPLPSLRAPPPLLTSNVSNNSNNHNHHHLHHNSSPNSSTANGSAGVLSSFPQLTPTITNATHSTISTISTISSSSSTESAASSSSNNTNGSKPKSKRSSKGRVFQCTGYPGCNMSFTRSEHLARHKRKHTGERPFTCPYCSKNFSRLDNLRQHKQTVHAYETYLTKDKSDSKLLIERSKLKKKMKQSEQKKQQQHQQQQQQQHESANLQSSQQRQQQPQQLQLQSQYTYGQPSPVPPSQNPTSSFTPSHYGNQVYMPGNYPTQGQHQQQQPLQGQPFSSHVPIPSVYNGQYSVPLQQSQSQHKPLPPLPHQVDQQQQPQLQTTLPQINKDSYEQEQQQQQSQCTPTAGNANSSSDELKIPTHTFKPKKRPQPLSLHHSTYESDEDIDLVNGGGTIKSAQLPAPRSAMSEVDPSSGQGGGATSISGLNNIGTSFPPPPKSASSVASSTPHLVSPLSPMFHMSFGSNSRTPLSMQQQQQQQQQQQQQQQQGSLSISYPRSTSLTNNSNAVNGMMKSPLSQQFPSTSTPTTQTHDLNNNNSLPSIKNLPIPGNFHSSNGGGPMNVNNASVGGGERRDVRNVNGHSIGSVGSLIHNEEESTTIASTSNNNANVTASTSMNTTTSETLGKSNWLKGVLNNDEKRQ
Protein: Conserved protein (O06389)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
Sequence:
MQLPQWLARFNRYVTNPIQRLWAGWLPAFAILEHVGRRSGKPYRTPLNVFSADVDGRAGVAILLTYGPNRDWLKNITAAGGGRMRRYGKTFGVANPRRLTKAEAAPYVSSRWRPVFARLPFDEAVLLTKAD
Protein: Nuclear hormone receptor family member nhr-115 (O16662)
Organism: Caenorhabditis elegans
Function: Orphan nuclear receptor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- CYtochrome P450 family
- SNF2 N-terminal domain-containing protein
- phospholipase A2
- CaDmium Responsive
- P-type Cu
Sequence:
MKKVLFPCQICGQNSHGTHFGIVSCRACAAFFRRSVNSKWARKGCLTNFKDKGSCFCKPCRLRKCVEIGMDASKFQYDRDAISAIKHPKIFPSVSYYVGRPEFLMFSDSNVTSQKTFIDVQNLVFEVSRYLDHGCETPIYAENQLKKLTLGFKLMQFDYQNVKFFDKIGKAEFIDIIEYYFLTVAKWIAHFDEFRKLDQSLQIKLLQAIWHVWSKIHKCASTAFYRKSNPNAKPTQKILRNVCMDRMHVHKLDTSWMSDYPTEHVTRFMLTHHVYDFKIVESLLKLDPTDVELTFMFAQLCFEYAGKRFQGEILKITDHFQQVLSNDLHHYYITDQRRERYFQRLTDLMKVNNLIQRSIWETRPHRELGRVFEISKLEFSHPEMFDDSGFC
Protein: Mannan endo-1,4-beta-mannosidase 3 (EC 3.2.1.78) (Beta-mannanase 3) (Endo-beta-1,4-mannanase 3) (AtMAN3) (Q9SG94)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- At2g21655)
- Protein DOWN-REGULATED IN DIF1 11
- Bifunctional fucokinase/GDP-fucose pyrophosphorylase
- Defensin-like protein 44
- Inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- EP1-like glycoprotein 2 lectin family protein)
- At4g07515)
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Alpha-mannosidase 2
- F3F19.21 protein family protein)
Sequence:
MKCLCFVVLLAILIAQNSSDLGVKSASSDGFVSRKGVQFILNGKPFYANGFNAYWLAYEATDSTTRFKITYVFQNATIHDLTIVRTWGFRDGGYRALQIAPGVYDEKTFQGLDFAIAEAKRLGIKMIITFVNNYSDFGGRKQYVDWAKNTGQNVSSDDDFYTNPLVKQYYKNHVKTMVNRVNTFTKVEYKDEPTIMGWELMNEPQCRADPSGKTLTAWMNEMALYVKSVDSKHLLSTGLEGFYGDSSPQRKTSLNPVAANVLGTDFIANHKLDAIDFASIHSYPDLWFPNLDEKSRLNLLRKWLECHLEDAQNILKKPLILGEFGKPTNTPGYTQAQRDAVFNATFDTIYESAEKGGPAAGALFWHVISDGMNNFKDPLSIVLSENSTTVNIITEESRKLGLIRGKGKLSKTKI
Protein: Ag1 (Anterior gradient 1) (F1Q8B0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Si:dkey-193p11.2.
- ETS domain-containing transcription factor ERF
Sequence:
MQHWPLCILLLCLVFCDVSTQRKKKTVQTLSRGWGDDISWAQTYEEGLAKAAKSKKPLMIIHHLEDCPHSIALKKAFSEHQSIQRMAKSEFIMLNLVHETTDTHLAPDGFYVPRIMFVDPTLTVRADIVGKYANRMYTYEPDDIDFLAENMIKAKILLKEEHEEHDDL
Protein: RT1 class Ia, locus A1 (A0A0G2K1E1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Beta-2-microglobulin
- TAP binding protein
- T-cell surface glycoprotein CD8 alpha chain
- T-cell surface glycoprotein CD8 beta chain
- T-cell receptor alpha chain V region PHDS58-like.
- Killer cell lectin-like receptor subfamily A, member 22
- Histocompatibility 2, class II antigen E alpha
- Rano class II histocompatibility antigen, B-1 beta chain
- Natural killer cells antigen CD94
- Rano class II histocompatibility antigen, D-1 beta chain
Sequence:
MEAMARPTLLLLLAAALAPTKTRAGSHWMRYFHTAVSRPGLGEPRYISVGYVDDTQFVRFDSDAENPRYEPRARWMEREGPEYWERNTRIVKGKEQIFRDNLRTLLGYYNQSEGGSHTLQLMYGCDVGSDWSLLRGYEQHAYDGRDYIALNEDLKTWAAADFEAQKTRSKWEREGVAERSRAYLEGECVKWLRRHLEHGKEALLRLDPPEAHVTLHPRPEGDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVALGKEQKYTCLVEHEGLPEPLTQRWEAPPSTDSNMETNVIYVVVGALVITGAVIIGAVVAVVRKRNTGGTGGDYAPAPA
Protein: Viral inhibitor of caspase-8-induced apoptosis (vICA) (F5HAY6)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays a role in the inhibition of apoptosis by interacting with the pro-domain of pro-caspase-8/CASP8 and thus preventing its activation.
Interaction partners:
Sequence:
MDDLRDTLMAYGCIAIRAGDFNGLNDFLEQECGTRLHVAWPERCFIQLRSRSALGPFVGKMGTVCSQGAYVCCQEYLHPFGFVEGPGFMRYQLIVLIGQRGGIYCYDDLRDCIYELAPTMKDFLRHGFRHCDHFHTMRDYQRPMVQYDDYWNAVMLYRGDVESLSAEVTKRGYASYSIDDPFDECPDTHFAFWTHNTEVMKFKETSFSVVRAGGSIQTMELMIRTVPRITCYHQLLGALGHEVPERKEFLVRQYVLVDTFGVVYGYDPAMDAVYRLAEDVVMFTCVMGKKGHRNHRFSGRREAIVRLEKTPTCQHPKKTPDPMIMFDEDDDDELSLPRNVMTHEEAESRLYDAITENLMHCVKLVTTDSPLATHLWPQELQALCDSPALSLCTDDVEGVRQKLRARTGSLHHFELSYRFHDEDPETYMGFLWDIPSCDRCVRRRRFKVCDVGRRHIIPGAANGMPPLTPPHAYMNN
Protein: ABC transporter, putative (Q385F7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MQEPFDANANGGVHEPSTTTLQMDSRSSATTGSVEVSTHDISLHAVRKDSNRIGDGVSGVHNCRASFMDMFRATVQRLFRQTVRRKSEVVLEVVVPLLFMTVTVILWSIWGTNHIEESPRIDYGALPRTMNPTIYQHFTCSAKLGGVPGLRVCRNKKEVECIKDEITAPFRGVCVHKRVGATTLVAFFANGFVGRIAPIPPLDTLIMHQWLARHANTRVLIPRGLIPNNRLSAIQSSGLLYFVGNASVVRGIVQHLGRVSHYFTNVYGGTFETLPEAQEEVRRQTLNWGIVHVRCFEPGSLDVQIYLNGTALPTLRETVANAYPGGFQHNRAEMYALSGYLTLQKEISEHHMGLFNPGMGLNITPYMMPQGFVEFTETPLLQTARGILPVLFGLAFLFTVTSRVHVNVMEKESKIRETILIMGMRKSVLNVVWFLKPLLIDLVVCSLITVLLKLTYMPRSGSVSLFVVLFVFALTTIPLSGVISCFFSKTRLALLVSPIIYFLMTLPYAVERPTNGLLCMISALLSPTAFISIVHGALAMEVSGGFHLTQLRIGGDPVCAEMLLIMLVADLVLYTLLMLYLDTVLQNDWGTTKHPLFFITNPIRALFWERRKVGTSACPFTDGRADNGVFEDIGDTKEEATVVMAGLRKEYQRGGDTFVAVNNFCWSMGRGEISVLLGLNGAGKSTVINMITGMVKPDAGDCYVNGRSVRRELSAARQQMGFCPQHNILWPQLTCREHLEFFGKIKGLKGKALDLAVGHVLHETGLSEKSDDLAGHLSGGQKRMLSVGIAFVGGSPLVLLDEPTAGMDASSRRHAWGLLQRMAAHHTILLTTHFMDEADILGHRIAILNDGRLQCSGSSMFLKSKLGLGYSLTVVMRSKDNFCFVDDAVKKHVPGAELLSYCGCEVIYRLPLGGVAAFPSLIEKLEIASDVNLNSYSLAATTLEEVFLRVCGGQQCSAEKPRDCSSLWGRARRRAAGITQLKAIMLKRIFTALRDRRMHMLQVVCLTSVLLATVLIGSNPAQVGPLPLTFDLYDEKVIVDSANCGLFWGKSPGVPNVHISEISAKDTRELSIYGMKTWFAHEYPRYAAIFCGDRMLYNPKLRGMPVVMLYNSSALHQVAITMSMFYQLVLQRVSGVQANVSWSVGVLEDEATYVGALQLMLIGAIMMIPLTLISSNPLAWVVKERECGSLHMQRIAGLRFPIYWASNFLFDITMYFISVSAIVSVLMLFDQEDYVGSETIGAFITALMLYGLTSIVFAYLLSFLFREHSKAQLVVMGFNFVVGFLSVIVVYVFSLLEITRETSESLRWPFRLIPSFCVGEAIINISHFRFGKAVGNATSAFDMDVTGYPFIYLAVEFPIFSLLGFLFDHPRRRAWWNRRSYDRTKVFDEAHSGDSDVEEERCRVCLPMVDGPGYPPARVVNLSKKYPNGKEAVRDLFFLVSSGEIFALLGTNGAGKTTTMSILCQELMPTGGVVETCGCDIVKQGGKALRCIGYCPQFDTCISLLSVEEHIRLQAGLYGMVGEEVENVVTDLLYMCDLTKYRKSLAGELSGGNRRKLSLAVALVGGPGVIFLDEPTAGMDPIARRKIWSVIERAACQCAVVLTTHHLEEVEALAHRVAIMKDGTMRCVGRNAHLKDKYGAGYEMHICVAEGELPALVREFVDRQFAGATLRECKGRQLVYALPRSTSLADAFRTLESSKDLLGIVDYSVSQATIERVFLQITEQDEWVSKQTTEMDIV
Protein: Protein transport protein Sec24A (SEC24-related protein A) (Q3U2P1)
Organism: Mus musculus (Mouse)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:O95486}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95486}; Cytoplasmic side {ECO:0000250|UniProtKB:O95486}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O95486}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95486}; Cytoplasmic side {ECO:0000250|UniProtKB:O95486}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O95486}.
Interaction partners:
- Protein SEC13 homolog
- Protein transport protein Sec31A
- Protein transport protein Sec16A
- Protein transport protein Sec31B
- Protein transport protein Sec23B
- Protein transport protein Sec23A
- Small COPII coat GTPase SAR1B
- Vesicle-trafficking protein SEC22b
- SEC24 homolog D, COPII coat complex component)
- SEC24 homolog C, COPII coat complex component
Sequence:
MAQPRIPAARGAAASLQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGSYPRPMPAKTLNPFSAQSNYGGSQGSGQTLNSPLVTSGPVLPSLHSGPVPRMPLPTSQNPAATPMPSGSFLPGANPPPPLNWQYNYPSTGPQTNHFPHVAPPTLPGNPNLTADHQYVSSGDPALQTSFKKPGSALPLQNPPLPPTFQPGAPPGPPPAGGPPPSRGPAPQKTPPRAAPPPSFNSAVNQEGITSNANNGSTAAHNTYDEIEGGGFLATPQLVNQNPKTSRSVGSAYPSLPPGYQNSAPPVAGMPPPSLSYPSGPQAFTQTPLGANHLTASMSGLSLHPEGLRVVNLLQERNMLPSTPLQPPVPNLLEDIQKLNCNPELFRCTLTSVPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVNFLDQRRWKCNLCYRVNDVPEEFMYNPLTRVYGEPHKRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRSSAKEIHLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGADVQAISGLLANMAVDRSVTASLSDARDALVNAVIDSLSAYRSSVLSGQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTSIRLDERIFAMCQVKSQPLVHLMLTTHPSLYRVDNLSDEGALNINDRTIPQPPILQLSVEKLSRDGAFLMDAGSLLMLWVGRNCSQNFLSQVLGVQNYASIPQTMTDLPELDTPESARIAAFISWLREQRPFFPVLYVIREESLMKAAFLQSLVEDRTESALSYYEFLLHIQQQVNK
Protein: Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) (A0A0A0MTH3)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, myofibril, sarcomere {ECO:0000256|ARBA:ARBA00004204}.
Interaction partners:
Sequence:
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRGPSPHPLACVLSSLPTCLLPLYHSLGCFSSLERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
Protein: Probable is like-2 transposase (P96360)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Possible transposase
Sequence:
MRASPADGLAITGLSWKGSRGGSVREVRGGTCPLSSGRGKRCGSAITVGRWMVPATRCSPTLPRCSGWTLRWPRISRSCCRWIPRTCGHTSIRRAPARTRSPQGALSDYKKSADEPDDHAIGRSRGGLTTKIHALTDQREAPVRIRLTAGQAGDNPQLLPLLDDYRHASTEYALGSTDFRLLADKAYSHPSTRAALRSKKIKHTIPERQDQIDRRKAKGSAGGRPPAFDAALYGLRNTVERGFHRLKQWRGIATRYDKYALTYLGGVLLACAVIHARVGTPKLGDTP
Protein: DNA replication and repair protein RecF (Q9RVE0)
Organism: Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
Function: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- DUF721 domain-containing protein
- Recombination protein RecR
- DNA repair protein RecO
- Protein RecA
- DNA repair protein RecN
- Chromosomal replication initiator protein DnaA
- Beta sliding clamp
- Regulatory protein RecX
- DNA topoisomerase
- ATP-dependent DNA helicase RecG
Sequence:
MGDVRLSALSTLNYRNLAPGTLNFPEGVTGIYGENGAGKTNLLEAAYLALTGQTDAPRIEQLIQAGETEAYVRADLQQGGSLSIQEVGLGRGRRQLKVDGVRARTGDLPRGGAVWIRPEDSELVFGPPSGRRAYLDSLLSRLSARYGEQLSRYERTVSQRNAALRGGEEWAMHVWDDVLLKLGTEIMLFRRRALTRLDELAREANAQLGSRKTLALTLTESTSPETYAADLRGRRAEELARGSTVTGPHRDDLLLTLGDFPASDYASRGEGRTVALALRRAELELLREKFGEDPVLLLDDFTAELDPHRRQYLLDLAASVPQAIVTGTELAPGAALTLRAQAGRFTPVADEEMQAEGTA
Protein: Vascular endothelial zinc finger 1 (J9JIC7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XLNRHKLSHSDEKPFECPICNQRFKRKDRMTYHVRSHEGGITKPYTCSVCGKGFSRPDHLSCHVKHVHSTERPFKCQFSSLMQTCTAAFATKDRLRTHMVRHEGKVSCNICGKLLSAAYITSHLKTHGQSQSINCNTCKQGISKTCMSEETSNQKQQQQQQQQQQQQQQQQQQHVTSWPGKQVETLRLWEEAVKARKKEAANLCQTSTAATTPVTLTTPFSITSSVSSGTMSNPVTVAAAMSMRSPVNVSSAVNITSPMNIGHPVTITSPLSMTSPLTLTTPVNLPTPVTAPVNIAHPVTITSPMNLPTPMTLAAPLNIAMRPVESMPFLPQALPTSPPW
Protein: Ras-related protein Rab-12 (EC 3.6.5.2) (P35284)
Organism: Rattus norvegicus (Rat)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).
Subcellular location: Recycling endosome membrane {ECO:0000250|UniProtKB:P35283}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:P35283}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P51152}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:P35283}.
Interaction partners:
- Rab GDP dissociation inhibitor alpha
- DENN domain-containing protein 3
Sequence:
MDPSAALHRRPAGGGLGAVSPALSGGQARRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREISRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDVLRSELSNSILSLQPEPEIPPELPPPRPHVRCC
Protein: Auxin response factor 19 (Auxin-responsive protein IAA22) (Q8RYC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Involved in ethylene responses. Regulates lateral root formation through direct regulation of LBD16 and/or LBD29. Functionally redundant with ARF7. Involved in cellular dedifferentiation during callus formation on callus-inducing medium (CIM) and in an ATXR2-dependent manner.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00326, ECO:0000269|PubMed:29184030, ECO:0000269|PubMed:9342315}.
Interaction partners:
- Auxin-responsive protein IAA14
- Auxin transporter protein 1
- Auxin-responsive protein IAA3
- LOB domain-containing protein 29
- LOB domain-containing protein 16
- Auxin-responsive protein IAA8
- Auxin-responsive protein IAA1
- Histone-lysine N-methyltransferase ATXR2
- Auxin-responsive protein IAA17
- Auxin-responsive protein IAA7
Sequence:
MKAPSNGFLPSSNEGEKKPINSQLWHACAGPLVSLPPVGSLVVYFPQGHSEQVAASMQKQTDFIPNYPNLPSKLICLLHSVTLHADTETDEVYAQMTLQPVNKYDREALLASDMGLKLNRQPTEFFCKTLTASDTSTHGGFSVPRRAAEKIFPPLDFSMQPPAQEIVAKDLHDTTWTFRHIYRGQPKRHLLTTGWSVFVSTKRLFAGDSVLFVRDEKSQLMLGIRRANRQTPTLSSSVISSDSMHIGILAAAAHANANSSPFTIFFNPRASPSEFVVPLAKYNKALYAQVSLGMRFRMMFETEDCGVRRYMGTVTGISDLDPVRWKGSQWRNLQVGWDESTAGDRPSRVSIWEIEPVITPFYICPPPFFRPKYPRQPGMPDDELDMENAFKRAMPWMGEDFGMKDAQSSMFPGLSLVQWMSMQQNNPLSGSATPQLPSALSSFNLPNNFASNDPSKLLNFQSPNLSSANSQFNKPNTVNHISQQMQAQPAMVKSQQQQQQQQQQHQHQQQQLQQQQQLQMSQQQVQQQGIYNNGTIAVANQVSCQSPNQPTGFSQSQLQQQSMLPTGAKMTHQNINSMGNKGLSQMTSFAQEMQFQQQLEMHNSSQLLRNQQEQSSLHSLQQNLSQNPQQLQMQQQSSKPSPSQQLQLQLLQKLQQQQQQQSIPPVSSSLQPQLSALQQTQSHQLQQLLSSQNQQPLAHGNNSFPASTFMQPPQIQVSPQQQGQMSNKNLVAAGRSHSGHTDGEAPSCSTSPSANNTGHDNVSPTNFLSRNQQQGQAASVSASDSVFERASNPVQELYTKTESRISQGMMNMKSAGEHFRFKSAVTDQIDVSTAGTTYCPDVVGPVQQQQTFPLPSFGFDGDCQSHHPRNNLAFPGNLEAVTSDPLYSQKDFQNLVPNYGNTPRDIETELSSAAISSQSFGIPSIPFKPGCSNEVGGINDSGIMNGGGLWPNQTQRMRTYTKVQKRGSVGRSIDVTRYSGYDELRHDLARMFGIEGQLEDPLTSDWKLVYTDHENDILLVGDDPWEEFVNCVQNIKILSSVEVQQMSLDGDLAAIPTTNQACSETDSGNAWKVHYEDTSAAASFNR
Protein: Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) (Galactitol 2-dehydrogenase) (EC 1.1.1.16) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Q59787)
Organism: Cereibacter sphaeroides (Rhodobacter sphaeroides)
Function: Catalyzes the oxidation of D-sorbitol (D-glucitol) to D-fructose. Can also catalyze the oxidation of galactitol to D-tagatose and the oxidation of L-iditol, with lower efficiency.
Interaction partners:
Sequence:
MRLDGKTALITGSARGIGRAFAEAYVREGARVAIADINLEAARATAAEIGPAACAIALDVTDQASIDRCVAELLDRWGSIDILVNNAALFDLAPIVEITRESYDRLFAINVSGTLFMMQAVARAMIAGGRGGKIINMASQAGRRGEALVGVYCATKAAVISLTQSAGLNLIRHGINVNAIAPGVVDGEHWDGVDAKFADYENLPRGEKKRQVGAAVPFGRMGRAEDLTGMAIFLATPEADYIVAQTYNVDGGNWMS