wanglab/gogpt-training-data huggingface dataset:
Protein: Voltage-dependent T-type calcium channel subunit alpha (Q5SUF6)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
Interaction partners:
Sequence:
MDEEEDGAGAEESGQPRSFTQLNDLSGAGGRQGPGSTEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLEPYYQTENEDESPFICSQPRENGMRSCRSVPTLRGEGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAVGVRAGLLSSPVARGGQEPQPSGSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRVPRASPEIQDRDANGSRWLMLPPPSTPTPSGGPPRGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPEMLKDKALVEVAPSPGPPTLTSFNIPPGPFSSMHKLLETQSTGACHSSCKISSPCSKADSGACGPDSCPYCARTGAGEPESADHEMPDSDSEAVYEFTQDAQHSDLRDPHRRRRPSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEIGKREDTSGQLSCIQLPVNSQGGDATKSESEPDFFSPSVDGDGDRKKRLALVALGEHSELRKSLLPPLIIHTAATPMSLPKSSSTGVGEALGSGSRRTSSSGSAEPGTAHHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEDRASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRSSASEHQDCNGKSASGRLARTLRADDPPLDGDDGDDEGNLSKGERLRAWVRARLPACCRERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLKRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGVNSPDSPKPGAPHTTAHIGAASSGFSLEHPTMVPHTEEGPVPLGPDLLTVRKSGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGLPKAQSGSILSVHSQPADTSCILQLPKDAHYLLQPHGAPTWGAIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSSFWGGSSIQVQQRSGSQSKVSKHIRLPAPCPGLEPSWAKDPQETRSSLELDTELSWISGDLLPSSQEEPLSPRDLKKCYSVEAQSCRRRPGSWLDEQRRHSIAVSCLDSGSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGPRPPCSPGVCLRRRAPASDSKDPSASSPLDSTAASPSPKKDALSLSGLSSDPTDLDP
Protein: Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) (P97930)
Organism: Mus musculus (Mouse)
Function: Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+).
Interaction partners:
- Thymidine kinase, cytosolic
- Thymidylate synthase
- Deoxyuridine triphosphatase.
- Ribonucleoside-diphosphate reductase large subunit
- Deoxycytidylate deaminase
- Thymidine kinase 2, mitochondrial
- Nucleoside diphosphate kinase 6
- Adenylate kinase 9
- Ribonucleoside-diphosphate reductase subunit M2
- Nucleoside diphosphate kinase 3
Sequence:
MASRRGALIVLEGVDRAGKTTQGLKLVTALCASGHRAELLRFPERSTEIGKLLNSYLEKKTELEDHSVHLLFSANRWEQVPLIKAKLNQGVTLVLDRYAFSGVAFTGAKENFSLDWCKQPDVGLPKPDLILFLQLQLLDAAARGEFGLERYETGTFQKQVLLCFQQLMEEKNLNWKVVDASKSIEEVHKEIRAHSEDAIRNAAQRPLGELWK
Protein: Uncharacterized protein YcfJ (P0AB35)
Organism: Escherichia coli (strain K12)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein YpfG
- Osmotically-inducible lipoprotein B
Sequence:
MNKSMLAGIGIGVAAALGVAAVASLNVFERGPQYAQVVSATPIKETVKTPRQECRNVTVTHRRPVQDENRITGSVLGAVAGGVIGHQFGGGRGKDVATVVGALGGGYAGNQIQGSLQESDTYTTTQQRCKTVYDKSEKMLGYDVTYKIGDQQGKIRMDRDPGTQIPLDSNGQLILNNKV
Protein: RE11224p (Q8SXK8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MERTVEIEDSESNNPIIIDASIKTDPLISVENLSTVSENNFELDLIDGSTNGENSSNAENESPVQDTSNILIKGEDDKAIENCKSQDTTKSSSEKNVNDPTSIASDLSAENTKADLVSLNEPKTYEPTTIAPDLKMENTKNSIPSPIKPNVNDQTSSASDLTAENTKADHDSLNKPKDFNNQILNIISDIDINIKAQEKITQLKEQELKLIQKQNDLANEIHKQQILAKQLSAQNQLKQNECQSGELDLHSQYQNERGGPTSTLYQEKNIASKESANVSKTVDLRKIFTPATDAAEILPKNHFQQYQQRPVLSPNILPAYSDAGKHRVQLNIHQNQLIEKYSKPGLQVVQSPWKAALQTGSASSAFLEDTKSFSPPALTPIPSSQAGSKDWTDANEPMPHGSSRRNTNAVASSPRSVIVPSNPQRDLAYTPCVAQGWGGRSVELPKGLYVPKEISLSSYAAPSQQCEIHSKHFERPYEDTFPRTFPRNNYSANNNFPGNDGIGEFPLSKPTGLTTGTLHQQPYSPTSYKKTVPGLEKVENFARYEQPDRKRLTSGSPQYLNALQNSQVRNASPIPFGTSLNEQTSWPPRSVLLQGGSPSPLPNHVQTFNKCAKGWGSIPVKQQSYSSQYNLPGNLPYSDF
Protein: NAD-dependent epimerase/dehydratase family protein (Q86AQ3)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Small ribosomal subunit protein eS30
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS10
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL32
Sequence:
MSIVENNDNLVAVTGATGFLGAYIVRDLLEQNYRVLAFVRDPYNQEKLKTLKSFDPTGSKLTFTGGDLETIDYEKELKNVNYVIHTASPFKYSSPDPWGEIINPAINGTLGVLKAASKISTIKKVIVTSSGLAVYDIGTKKPEINDDDWSNVQDPINQPYPYSKVAAEKKAWEYIKENNENPSTNHFKLVVINPSYILGAALSPLVNASVATIVRHLTLAEKPRNVAIGVVDVRDVSRSHLIALENDDANDQRLLVSAKVVTFKSISDSIVQLFPQFKFNTNTLNNEDPEPFIFNLKSTKLDKLNFGQFIPFDETLKTMTKHLLDLKIINPELKN
Protein: Cyclic nucleotide-gated channel alpha-3 (CNG channel alpha-3) (CNG-3) (CNG3) (Cone photoreceptor cGMP-gated channel subunit alpha-3) (Q16281)
Organism: Homo sapiens (Human)
Function: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12815043, ECO:0000269|PubMed:35233102}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cyclic nucleotide-gated channel beta-3
- Guanine nucleotide-binding protein G
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
- Melanopsin
- Cyclic nucleotide-gated channel alpha-2
- Guanine nucleotide-binding protein G
- Retinoid isomerohydrolase
- Cyclic nucleotide-gated channel beta-1
- Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
- Glycine N-acyltransferase-like protein 1
Sequence:
MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ
Protein: Cysteine-rich secretory protein LCCL domain-containing 1 (CocoaCrisp) (Q8CGD2)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MMCKAQEWLRVTALLFVARAVPAMVVPNATLLEKLLEKYMDEDGEWWTAKQRGKRAITDNDMQSILDLHNKLRSQVYPTASNMEYMTWDVELERSAESWAEMCLWEHGPASLLPSIGQNLGAHWGRYRPPTFHVQAWYDEVRDFSYPYENECDPYCPFRCSGPVCTHYTQVVWATSSRIGCAVNLCHNMNIWGQIWPKAVYLVCNYSPKGNWWGHAPYKHGRPCSACPPSFGGGCRENLCYKEGSDRYYTPREEETNEIERQQSQVHDTHVRTRSDDSDRNDVISTQQMSQIVSCEVRLRDQCKGTTCNRYECPAGCLDSKAKVIGSVHYEMQSSICRAAIHYGIIDNEGGWVDVTRQGRKHYFIKSNRNGIQTIGKYHSANSFTVSKVTVQAVTCETTVEQLCPFHKPASHCPRVYCPRNCMQSNPHYARVIGTRIYSDLSSICRAAVHAGVVRNHGGYVDVMPVDKRKMYTASFQNGIFSESLQNPTGGKAFRVFAVV
Protein: Uncharacterized protein, isoform C (A0A0B4KEI1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 5B, isoform A
- Cytochrome c oxidase subunit 5B-like
- Mitochondrial-processing peptidase subunit beta
Sequence:
MYIHISENNTVAISLTDRLKASKLTRRGNKFSNLFKMSSNSLFETDEDVAQANKLSRKVKESPFMLVGIAGFVAAGLIGAYKYRNRGSMSTSVFLMQLRVAAQGTVVGCLTAGLAYTMAKEYLLHEEPKSNTRPDE
Protein: Uncharacterized membrane protein YkgR (C1P5Z8)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:21778229}; Single-pass membrane protein {ECO:0000305|PubMed:21778229}.
Interaction partners:
- Uncharacterized membrane protein YohP
- Uncharacterized protein YoaJ
- Uncharacterized protein YshB
- Uncharacterized protein AzuC
- Uncharacterized protein YobI
- Uncharacterized protein YnbG
Sequence:
MKENKVQQISHKLINIVVFVAIVEYAYLFLHFY
Protein: Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Nuclear body-associated kinase 3) (Nbak3) (Q9ERH7)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Cellular tumor antigen p53
- Ras association domain-containing protein 5
- FAS-associated death domain protein
Sequence:
MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSGCVFQERTYPQIHVNGRNFGNSHPSTKGSAFQTKIPFTKPRGHSFSLQAGAIVVKDTAGATKVLAAQAQQAGVEAPRAVVWRNRLHFLEGPQRCGLKRKSEELENHSGAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTSGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGGDLLAEKADRREFVNLLKKMLLIDADLRITPIETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSPSSCETNNHSKMSLLRPVASNGTAALAANFTKVGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHYNSVMPPPLLTNQITLSAPQPISVGIAHVVWPQPATTKKNKLCQNRSNSLQNTNIPHSAFISPKIISGKEVEEVSCVDTQDNHTSEGEAGTCREASVRQDSSVSDKQRQTIIIADSPSPAVSVITISSDSDDEETSPRPSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCETVDGSPTSDSSGHDSPFAENSFVEDAHQNTELGTCAGPEAKPAVGTAVEPPVGRESGLSVDEHMANTDSTCQPLRKGQPAPGKLHQPPALGARQQKPAAAFPQQHLNLSQVQHFGTGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGSTHLGGQPTLLPYPSSASLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGINPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM
Protein: Uncharacterized protein (Q57ZA6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRVAVLLAWPSAPFVSGGSGFGGSSGGSSMTKFAHRAAALKRKYRGRGQYDFARREAERFLETEVPQNEINVWIEQGNNAVALAQLLSFFEIEPDTSLQALITNKLVRTLDDKNHDGVTRLLAAVALTQRGDQYLERTFATVDRVLNEISQEGGSSNTDYHDFWNLIECAAKVLQRGGKHAPSTLSETLAQVAVTRLQNTPTTDMPRMQPPLLRVYSWLVRTGKVAEASHFLVALLDHSGEFHSYDFSTLMNSCLRHHQLLPFPPQLQQRLARAGLMYSTTANGRDVASIIGSVAKMVGSLQPGRNGLTQHDVCELGGRLSTLLEEYEPRVMSFFDCNDKLHWSHCDDMTTIAFAYEMGGRLRYRNVFLAYQAYVGRHVGRFEPQQLAMAAGILRRSSLLSQELAVRLGERIETVLGEFSLSEISHICATFAPMAPSWMPEAKAVASRLLQPECSSHTKLLLALAFPDDEALHAQVNLSDVSARQLVDALSLVQGTKFDGALVAELVARLQAAQERFSPDEIRMLQASGRPELHSACVAFLSARFAEAEWTSDTLYCLPLAANLIPHARDTAKALEAAKTVSVSPEQFVSLVELMTGVFGGGSGDAICHFVVSGGQELLGAERIRMGTVLRYLEAVRPLAKMHPGPEWLARFREKFHERLCNINAKEMENLLCSLCTVYGSVTQQPLLEQILTELVNGPYGRLTQPDETTARITVLLAQAQQGALQTPLTQSSPMVKSVRSNADAYEPQLREAVRNIALPQEAEQKRVGRFTLKMTKALGEAPPVNELTVSQDLNESLSMDPFSNATIGMPGKTESKSSAGSDALVVAPPFAMNAGHTLTSSTEIGGASGSGAAPQTGLASNTNESSADAAGSTNRARGSNVHQQQQQQHQQQNEPDRYRTDKPAAAEGNPTGFNSTLWSMFKNPLSSAEDPQRSQHFGTSASASASTSSPVTLRSPETRTASPFMGLLNHNNPPTTMFASPPPEKHRPAAVPERSYSQQLEQKCHEEGQPRRTKIPLSDVRSAALKDNRSSGGTGQYSKQEYPKYELGNWGASPPSNTSWLSSASMWGAPEESPVVPQSNMEGLGGTWPSMKPQPTQAFGAPSSSNIFGLSTDQQQRDPYYYNQFHNQQQQYNQQANQPHQSQQFRQPQQFLYEQQQQQQQQQQQQQQQRHIPFHQPQQTQRPQHQQLQYHHQQQQQQQPPQWQQQQHQRFPQEQQHYFQQQQQAPQQQLFHHEHSGQQQKYNRQQREHQPGLIPGATSFGASAMQVLRPANTGLQRSNTPVVGGMLYSDQTSSSRARPVITKVLLKSTQLLPGAPQNDDDNPPFAKDLSGTNIGFQSPKKFIERSPRKEEEQEDDDGEEEEEGSEDTDEEAEEPPKKTRGARAEVGGKKANRAGKIRNDLKEWLDSPPEKELEPMRATRKKRAAAAATAVVKGKAKDTGKRGKSKDPAAGTRGAATAKGKAANKKTVAAKNSKAAVTATEKAKTAGKQAAVTAAEKPKGAGKQVAAAKNAKATAAATEKAKGANKQTAKTTKAKKPVAKPTAKKQPAEPAASKKKPGRKPTEKAKAGKR
Protein: Parvalbumin (E0WDA2)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MACAHLCKEADIKTALEACKAADSFNFKTFFHTIGFASKSADDVKKAFKVIDQDASGFIEVEELKLFLQNFCPKARVLTDAETKAFLKAGDADGDGMIGIDEFAVWVKQ
Protein: OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 (OTU domain-containing protein 2) (EC 3.4.19.12) (Deubiquitinating enzyme OTU2) (Q9LPT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Cysteine protease with a preference for 'Lys-63' and 'Lys-48' -linked ubiquitin (UB) tetramers as substrates.
Interaction partners:
- AT3g18860/MCB22_3
- Probable ubiquitin conjugation factor E4
- OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 3
- OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 4
- NPL4-like protein 2
- NPL4-like protein 1
- Cell division control protein 48 homolog E
- Cell division control protein 48 homolog D
- AAA-type ATPase family protein / ankyrin repeat family protein
- Cell division control protein 48 homolog A
Sequence:
MEGIIVRRVIPSDNSCLFNAIGYVMDKDKNKAPELRQVIAAAVASNKEKYNEAFLGKLNEEYCAWILNPDKWGGAIELSILADYYGREIAAYDIQTSRCDLYGQTRNYDERVMLIYDGLHYDALALSPFEGAEEDFDMTIYPVGKDRSIGSIEGLALNLVKDQQRKRSYTDTANFTLRCGVCQIGVIGQKEAVEHAQATGHVNFQEYK
Protein: Fatty acid desaturase 2 (Putative delta 6-desaturase) (Q8AY64)
Organism: Sparus aurata (Gilthead sea bream)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGGGGQLTEPGEPGSRRAGGVYTWEEVQSHSSRNDQWLVIDRKVYNVTKWAKRHPGGFRVINHYAGEDATEAFTAFHPDLKFVQKFLKPLLIGELAATEPSQDRNKNAAVIQDFHTLRAQAESDGLFRAQPLFFCLHLGHILLLEALAWLIIWLWGTSWTLTFLISIILATAQTQAGWLQHDFGHLSVFKKSSWNHILHKFVIGHLKGASANWWNHRHFQHHAKPNIFSKDPDVNMLHIFVLGDTQPVEYGIKKIKYLPYHHQHQYFLLVGPPLLIPVYFHIQIIRTMISRHDWVDLAWSMSYYLRYLCCYVPLYGLFGSVALISFVRFLESHWFVWVTQMNHLPMDIDHEKHHDWLTMQLQATCNIEKSVFNDWFSGHLNFQIEHHLFPTMPRHNYHLVAPLVHALCEKHGIPYQVKTMWQGIVDVIRSLKNSGDLWLDAYLHK
Protein: Vasotocin receptor 3 (I0CF49)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}.
Interaction partners:
Sequence:
ITFRFYGPDFLCRLIKYLQVVGMFASTYMLLLMSLDRCLAICQPLRSLHRRADRVSVLLTWLLCLLVSIPQIHIFSLRDVGNGVYDCWADFIQPWGPKAYVTWITLMVYIIPMLMLSICYGLISSKIWQNVKLKTAHGPSVGLGSGSRGGVVFARVSSTRLISKAKIRAVKMTFIIVLAFIVCWTPFFVQMWSVWDSNAPQEASPFIIAMLLASLNSCCNPWIY
Protein: Arhgef11 protein (Q7TQK9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
PAYQGSTSSRVEVNDSEVYPTEREPKKPSEGPGPEQRGQDKQLLAQEGPEQEEDAEELRALPCPPPSLDGENRGIRTRDPVLLALTGPLLMEGLADAALEDVENLRHLILWSLLPGHTVKTQAAGEPEDDLTPTPSVVSITSHPWDPGSPGQAPAISDNTQFPRPEGSQPEGEDVALCSLAHLPPRTRNSGIWDSPELDRNPAEEASSSEPAGSYKVVRKGNCFYVSMPAEPLDSSTEPPGTPPSLSQCHSLPAWPTEPPQHRGVTGGQRSSLVLRDMGVIFHTIEQLTVKLHRLKDMELAHRELLNSLGGESSGGTTPVGSFHTEAARWTDYSLSPPAKEALTSDPQNNQEQGSYPEEGSDTPLEDSATDTASSPGP
Protein: cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) (P61926)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Interaction partners:
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase inhibitor gamma
- Exportin-1
- THAP domain-containing protein 1
- THAP domain containing 6
Sequence:
MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEEDAQRSSTEQSGEAQGEAAKSES
Protein: Blanks (GH28067p) (Q9VRL8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEAKQLLAESCAKVDILEMKKALIPNPSAEEDAVAVIPLADNLKKTAMGGENKSDEKGTVSSEPKALSDQITSSMRVTKNKIADDKSSDVITDDATNGRKKQKKNKKAKIRPLTMPVTSKDALMVLNELKGVTVDNMQIKRDHEGKIMARVVVNSKKYEAEGSSVNSARNAACEKALQEILTTKMKAVLDGPGKSLESDEDDILEKMASYAIHKLGEEWKTDDIDVATLYNDLKNKQTSVVEPKKPLPETWKNMHPCMVLNYMRPQCTFIVSGGTGTNQNNTFSMSVCVDNCEFNAEGPSKKAARYKLSALVCNKLFGTDYPQK
Protein: TOBE domain protein (D5ARW3)
Organism: Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Interaction partners:
- Molybdenum transport operon repressor MopB
- Molybdenum transport operon repressor MopA
Sequence:
MKLSARNILAGKVTAVETGNVTTHVKIDIGGTVVTASITNEAAADLALKVGDEACAIIKASDVIVGKN
Protein: Golgi/endosome-localized DSC protein 1 (Q06104)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the Golgi/endosome-localized DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquinate Golgi/endosome membrane proteins. Competes with VLD1 to determine the subcellular localizations of the DSC complex. May be required for cell cycle progression.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:29355480}; Multi-pass membrane protein {ECO:0000269|PubMed:12829295}. Endosome membrane {ECO:0000269|PubMed:29355480}; Multi-pass membrane protein {ECO:0000269|PubMed:12829295}.
Interaction partners:
- Vacuole localized DSC protein 1
- UBX domain-containing protein 3
- Transmembrane E3 ubiquitin-protein ligase 1
- DSC E3 ubiquitin ligase complex subunit 3
- DSC E3 ubiquitin ligase complex subunit 2
Sequence:
MDNFESTAEGNLSIGNKRVYELRKRNFQRNLVNNLSFLGYVLISLEYIKYDRTVWTLITRAIVQSLISSPFPSDAKLRRLATLGADNNTTGVATLPGGRSIRFPGMFGTEMLYNSSSEAEQQDHDDTAIVSMKKQIRKFLFHGCLSLNMLFIILTILFPIDFFEPLSGSEPVDDGPKNTPSPFSNSDGLLLGERRGGLFLQMIGERLPKSNFSGNLGLVMFEFSILIVQFTLFSLTCVVLADLDFEEPERLEPVNSDGYDGSVIVARIPLNKTMNAILNDGNINDNNENASNSV
Protein: Homeobox protein Hox-C9a (Hox-C9) (Q9YGS6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Homeobox protein Hox-C6a
- Homeobox protein Hox-C4a
- Homeobox protein Hox-C6b
- Forkhead box protein P1-B
- Pre-B-cell leukemia homeobox 3a.
- Pre-B-cell leukemia transcription factor 1
Sequence:
MSATGPISNYYVDSLINHESEDVLASRFTATGPISSSSRPTPLVPECADYPSCSFAPKPPVFTTSWAPVHSQSSVVYHPYTHQPHLGTDSRYVRSWLEPIPGTVSFPGYAGNSRHYGLKPDTFQDPRAGDCLGSNGRTYTDYLYCSAVDIREKQQNTPSPETESLSSGKHKDDKAELDPNNPVANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQNRRMKMKKMNKEKNDSKEQ
Protein: Elongation factor Ts (EF-Ts) (Q9CDR5)
Organism: Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Function: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MAVTAAQVKELREKTGAGIMDAKRALVETDGNMEAAAELLREKGIAKAAKKADRVAAEGLTGIAVNGNVAAIVELNSETDFVAKNDQFVALVKETAELIASKKPATNEEALALETASGITLEAELVQATATIGEKITFRRFAVIEKTDAQHFGAYQHNGGKIGVVSVVEGADETLAKQVSMHIAAMNPTVLSADELDSEFVKAELAQMNHKIDEDNASRVLVNKPELPHHEFGSKSQLTEEVLAAAKASFEEELKAEGKPEKIWDKILPGKMAKFIVDNTKVDQQFALLAQLYIMDDSKTVEAFLESKGAKAIAFTRFEVGEGIEKAETDFAAEVEAAKAGL
Protein: L-dopachrome tautomerase yellow-f2 (EC 5.3.3.12) (Q9VG08)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages.
Subcellular location: Secreted {ECO:0000269|PubMed:12164780}.
Interaction partners:
- L-dopachrome tautomerase yellow-f
Sequence:
MLSPQFLILSLISGLQLLSLADADPMIEVFRWKQMDFYNRGDGHLSSGGRKDRPSFSAPVVFPGKYSRRKRKIMTSRDTPVVVSSRADSDDPNASYIPYNNVPMGATHFRGRLFVTMPRRRVGIPSTLNYIDLAEDGSNRSPKLRAYPNFALNQFNASAENLVSVYRTSVDACQRLWFIDTGMLEYPNNRQQIRRPSIWVVDLATDQVLKRFDVPESIAETGRGLASITVDVKAGQCGDAYAYIPDLVYRRLYVYHLRNDRIWSFEHNYFNFDPLSGDLSIGGQTFRWDDGIFSITLGAQKLDGSRDAYFHPMASTNEFVVSNRVLQQESNAARSDHGNDFRVLGSRGPSTQSTMHAYDPGTGVIFFDEIQRNGVGCWKTSKPISAENYGSVDSNAEDMIYPSDLSIDEDGTIWVMSNSMPIFIYSTLDTSIYNFRIWKQKASLAKRGTVCE
Protein: ER membrane protein complex subunit 6 (Transmembrane protein 93) (Q9BV81)
Organism: Homo sapiens (Human)
Function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785, ECO:0000269|PubMed:30415835}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}.
Interaction partners:
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 8
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 9
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 5
- Endoplasmic reticulum membrane protein complex subunit 7
- ER membrane protein complex subunit 10
- Dynactin subunit 4
Sequence:
MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASVLLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY