wanglab/gogpt-training-data huggingface dataset:
Protein: Kinesin-like protein KIN-7F (F4JUI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Agamous-like MADS-box protein AGL70
- Cell division cycle 45
- Regulator of nonsense transcripts UPF3
- B-box zinc finger protein 19
Sequence:
MEKTQMPVAREEKILVLVRLRPLNQKEIAANEAADWECINDTTILYRNTLREGSNFPSAYSFDKVYRGECPTRQVYEDGTKEIALSVVKGINCSIFAYGQTSSGKTYTMTGITEFAVADIFDYIFQHEERAFSVKFSAIEIYNEAIRDLLSSDGTSLRLRDDPEKGTVVEKATEETLRDWNHLKELLSICEAQRKIGETSLNERSSRSHQMIRLTVESSAREFLGKENSTTLMASVNFIDLAGSERASQAMSAGTRLKEGCHINRSLLTLGTVIRKLSKGRQGHINFRDSKLTRILQPCLGGNARTAIICTLSPARSHVELTKNTLLFACCAKEVTTKARINVVMSDKALLKQLQRELARLETELRNPASSPASNCDCAMTVRKKDLQIQKMEKEIAELRKQRDLAQSRLEDFMRMIEHNVASKPGTPHFGNHTDKWEDGSVSETSGVVDSDRRSFISDGMSTPLSISRAYVHSHSDDDDLDEDLPRRSEDLSEEYCREVQCIETEESVTVYNNKKDKRAEPENVLGCGEDANGETSVSQNVRVRSWNRRETVSGPSTPPENIGTGFLGRPESHKIAFPDLEFGSTVSRNDSMSSCGSDSTGTQSIRTPLGEEGGITSIRTFVEGLKEMAKRQGEVSNAEDSGKMRRDIGLDSMDREFERQRQEILELWQTCNISLVHRTYFYLLFKGDEADSIYIGVELRRLLFMKDSFSQGNQALEGGETLTLASSRKELHRERKMLSKLVGKRFSGEERKRIYHKFGIAINSKRRRLQLVNELWSNPKDMTQVMESADVVAKLVRFAEQGRAMKEMFGLTFTPPSFLTTRRSHSWRKSMPALF
Protein: Zinc finger E-box binding homeobox 2 (A0A1B0GVV8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM
Protein: Photosystem II reaction center protein J (PSII-J) (Q2LIM8)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01305}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01305}.
Interaction partners:
Sequence:
MADTTGRIPLWLIGTVTGIAVIGLIGVFFYGSYSGLGSSL
Protein: Methyltransferase like 17 isoform 4 (A0A0S2Z5L8)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MAAALKCLLTLGRWCPGLGVAPQARALAALVPGVTQVDNKSGFLQKRPHRQHPGILKLPHVRLPQALANGAQLLLLGSAGPTMENQVQTLTSYLWSRHLPVEPEELQRRARHLEKKFLENPDLSQTEEKLRGAVLHALRKTTYHWQELSYTEGLSLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGQSLREYMCVDRSAAMLVLAEKLLKGGSESGEPYIPGVFFRQFLPVSPKVQFDVVVSAFSLSELPSKADRTEVVQTLWRKTGHFLVLVENGTKAGHSLLMDARDLVLKGKEKSPLDPRPGFVFAPCPHELPCPQLTNLACSFSQAYHPIPFSWNKKPKEEKFSMVILARGSPEEAHRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVLTARRHGRDLYRCARVSSWGDLLPVLTPSAFPPSTAQDPSES
Protein: Protein MARD1 (FCS-Like Zinc finger 9) (Mediator of ABA-regulated dormancy1) (Senescence-associated protein SAG102) (Q8LGS1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway. Involved in seed dormancy control.
Subcellular location: Cytoplasm, Stress granule {ECO:0000269|PubMed:26978070}. Cytoplasm, P-body {ECO:0000269|PubMed:26978070, ECO:0000269|PubMed:29945970}.
Interaction partners:
- Zinc finger CCCH domain-containing protein 61
- Protein INCREASED RESISTANCE TO MYZUS PERSICAE 1
- Uncharacterized protein
- FCS-Like Zinc finger 16
- FCS-Like Zinc finger 3
- FCS-Like Zinc finger 1
- FCS-Like Zinc finger 2
- Uncharacterized protein PHLOEM PROTEIN 2-LIKE A4
- Cysteine proteinase RD21A
- At1g71190
Sequence:
MLRNKPRAAVTTKKQTSLLMADQPPPPKPNTCHCSPSLFSSPKFRFFTSKMMMTPFDSDFSLVSPTSILEANPSIFSSKNPKPVSYFEPTIPNPQRFHSPDVFGLADLVKDGDSNRDHSRKPVNKMVLFGSKLRVQIPSSADFGTKTGIRYPPCQLSPCVQTKVLAVSEIDQTEDYTRVISHGPNPTITHIFDNSVFVEATPCSVPLPQPAMETKSTESFLSRCFTCKKNLDQKQDIYIYRGEKGFCSSECRYQEMLLDQMET
Protein: Uncharacterized protein (Q4GZ44)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Treble clef zinc finger domain-containing protein
Sequence:
MELNLTQLPLVHITFCGRPAVSIGVVNLVGLFGSTDYVLLQRIGSQGQTALRKGDGGGRHSKDSRDSSLDSLEIENRVRSSNMKLCRNTGLPVGCYNVVEGGIYDVVRYSDLRKGKVKGMDFATLNRHSDGRPKTRRGCRSRRKRRRDGTVENAAQSTPSDTVSSSFKQPSTPVPTDPSGTSGGTNGVSQRAKVVRAAQPSERKAHQKATKVSQTSKQTGGKEAPAVDEKNSNGTKVERTRTTKPRAPGIPKERPPRVGKEKVQQLKPVAEAAPQHAPSRSPSPRQANSNFAAVVLTASDLRSCDLGSSLSNVSVCTDKAETQMTPTTGPVTTSMQLNKSKHVPSSTGRTAAQDNGAKKTPQVATPVGESANAKKQQDVVDVDNALLVGHGSSSNGKKEGGSTGLANVRTDHSRDVVDRRAAAAPSNSIVECPCAPDAASPELGFVTVESALSRDFSLGSSLASSADSVY
Protein: Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)] (P16382)
Organism: Mus musculus (Mouse)
Function: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Subcellular location: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Interaction partners:
- Cytokine receptor common subunit gamma
- Interleukin-13 receptor subunit alpha-1
- Interleukin-13
- Interleukin-4
- Interleukin-13 receptor subunit alpha-2
- Signal transducer and transcription activator 6
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase JAK2
- Interleukin-10
Sequence:
MGRLCTKFLTSVGCLILLLVTGSGSIKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRLPLGVTISCLCIPLFCLFCYFSITKIKKIWWDQIPTPARSPLVAIIIQDAQVPLWDKQTRSQESTKYPHWKTCLDKLLPCLLKHRVKKKTDFPKAAPTKSLQSPGKAGWCPMEVSRTVLWPENVSVSVVRCMELFEAPVQNVEEEEDEIVKEDLSMSPENSGGCGFQESQADIMARLTENLFSDLLEAENGGLGQSALAESCSPLPSGSGQASVSWACLPMGPSEEATCQVTEQPSHPGPLSGSPAQSAPTLACTQVPLVLADNPAYRSFSDCCSPAPNPGELAPEQQQADHLEEEEPPSPADPHSSGPPMQPVESWEQILHMSVLQHGAAAGSTPAPAGGYQEFVQAVKQGAAQDPGVPGVRPSGDPGYKAFSSLLSSNGIRGDTAAAGTDDGHGGYKPFQNPVPNQSPSSVPLFTFGLDTELSPSPLNSDPPKSPPECLGLELGLKGGDWVKAPPPADQVPKPFGDDLGFGIVYSSLTCHLCGHLKQHHSQEEGGQSPIVASPGCGCCYDDRSPSLGSLSGALESCPEGIPPEANLMSAPKTPSNLSGEGKGPGHSPVPSQTTEVPVGALGIAVS
Protein: Very long chain fatty acid elongase 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Elongation of very long chain fatty acids protein 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) (Q9EQC4)
Organism: Mus musculus (Mouse)
Function: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:23509295, ECO:0000269|PubMed:24569140}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03204}.
Interaction partners:
- Very-long-chain 3-oxoacyl-CoA reductase
- Very-long-chain
- Very-long-chain enoyl-CoA reductase
- Very-long-chain
- Very-long-chain
- Very-long-chain
- Very long chain fatty acid elongase 1
- Retinal-specific phospholipid-transporting ATPase ABCA4
- Ceramide synthase 3
Sequence:
MGLLDSEPGSVLNAMSTAFNDTVEFYRWTWTIADKRVADWPLMQSPWPTISISTLYLLFVWLGPKWMKDREPFQMRLVLIIYNFGMVLLNLFIFRELFMGSYNAGYSYICQSVDYSNDVNEVRIAGALWWYFVSKGVEYLDTVFFILRKKNNQVSFLHVYHHCTMFTLWWIGIKWVAGGQAFFGAQMNSFIHVIMYSYYGLTAFGPWIQKYLWWKRYLTMLQLVQFHVTIGHTALSLYTDCPFPKWMHWALIAYAISFIFLFLNFYTRTYNEPKQSKTGKTATNGISSNGVNKSEKALENGKPQKNGKPKGE
Protein: Pipsqueak protein (Q24457)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00320}.
Interaction partners:
Sequence:
MQNGGLLGVPMGFLDFTPEPPAPSATPVTVTEHVDLSCNPSTDTRDLSNTTEPLDIDNHLAQQIHRLDQSPMHSISHHHTGDESNSNLVQHIKSEVIEAKHLAAQHHALSQAQQQHAHHQAHQQHQQHQQQQHQQQQQHLHAQQLLAQSQLQQQQQQQQQQQQHHQQQQQQAAAAAAAAGVHGQHGGHVTHADIGGATVMEIDPSQIKHEPGMIITPEIVNMMSSGHMDMYNSDTSEDSMMIANGSPHDQKEPHYTNLDQQHGLGGSVCGPGPGGAGGGGGMSGGAGSGSGEKGQFNGPKAWTQDDMNSALDALKNQNMSLTKASAIYGIPSTTLWQRAHRMGIETPKKEGGTKSWNEDALQNALEALRSGQISANKASKAFGIPSSTLYKIARREGIRLAAPFNAAPTTWTPEDLERALEAIRAGNTSVQKASAEFGIPTGTLYGRCKREGIELSRSNPTPWSEDAMNEALNSVRVGQMSINQAAIHYNLPYSSLYGRFKRGKYDVVANTSGVALLNTSGNTTGSIEIIEHSQENSLHMLQQQFPYSPSPHPPTPQHHSTPQHHSSAQQGPPTPQHMQQYVVHMQQQQQQQQQQSPHPGHHPQHMQQDVVTSSSQVVHSQQQQQLQQIYQHHGTPVTASGSSAVSGGTSKRKKANKQKR
Protein: PelA (Q9HZE4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- PelB
- PelF
- PelD
- PelG
- PelE
- PelC
- PslA
- PslG
- GDP-mannose 6-dehydrogenase
- Alginate biosynthesis protein AlgA
Sequence:
MRFSKKGIAVLRLPSRRNILRPIECPLAWLAGLALALCAGTAAGAAGGPSSVAFWYAERPPLAELSQFDWVVLEAAHLKPADVGYLKEQGSTPFAYLSVGEFDGDAAAIADSGLARGKSAVRNQAWNSQVMDLAAPSWRAHLLKRAAELRKQGYAGLFLDTLDSFQLQAEERREGQRRALASFLAQLHRQEPGLKLFFNRGFEVLPELPGVASAVAVESIHAGWDAAAGQYREVPQDDRDWLKGHLDALRAQGMPIVAIDYLPPERRDEARALAARLRSEGYVPFVSTPALDYLGVSDVEVQPRRIALLYDPREGDLTLSPGHVYLGGLLEYLGYRVDYLPTDQPLPERPLSGLYAGVVTWMTSGPPLASDAFDNWIAARLDEKVPVAFLAGLPTENDGLLQRLGIRRLSQKLKVKPSTETHDQALLGSFEAPLVIRIRDLPALTVLDPARVTPALKLKGDGKEYVPVATADWGGFALAPYVLEEGSEHRRWILDPFAFLRKALRLVPLPSPDATTENGRRIATVHIDGDGFVSRAEVPGSPYAGQQVLEDFIKPYPFLTSVSVIEGEVGPKGMYPHLARELEPIARRIFADDKVEVASHTFSHPFFWQPQLAEQGENFEAQYGYKMAIPGYDKVDFVREVIGARDYIEQRLTTPRKPVKMIFWSGDALPDAATIKLAYDAGLMNVNGGNTALTRAFPSLTGLYPLIRPTRGGVQYYAPIINENVYTNLWQGPYYGFRGVIDTFALTDSPRRLRGLHLYYHFYSGTKQASIRTMHQIYAAMQAEHPLSLWMSDYIPRLEGLHRASLAKRADGSWQLRGFAALRTVRLDPALGWPDLGRSTGVAGVRDLPQGRYVHLSAANARLVLRDSRDPRPALEEANLPLKHWRYRDDGRVEFAFAGHLPLRLVVRAAGDCRLSAAGKAFPGKAGNGLWTFELPMEQVRDGQLVCR
Protein: Trimeric intracellular cation channel type A (TRIC-A) (TRICA) (27 kDa sarcoplasmic reticulum protein) (Mitsugumin-33A) (SPR-27) (Transmembrane protein 38A) (Q3TMP8)
Organism: Mus musculus (Mouse)
Function: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
Subcellular location: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:A5A6S6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A5A6S6}. Nucleus membrane {ECO:0000250|UniProtKB:A5A6S6}.
Interaction partners:
- Inactive phospholipid phosphatase 7
Sequence:
MDLMSALSLGELALSFSRVPLFPVFDLSYFIVSIIYLKYEPGAVELSRRHPVASWLCAMLHCFGSYILADLLLGEPIIDYFSNSSSILLASGVWYLIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFIMIATGWVKGSGVALLSNVEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFVFTMFMVSCKVFLTATHSHSSPFDILEGYICPVLFGATWGGDHHHDNHGAPHGMGLGTQHSGLPAKAKEELGEGSRKKKTKKAD
Protein: Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) (Q86XZ4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MSRKQNQKDSSGFIFDLQSNTVLAQGGAFENMKEKINAVRAIVPNKSNNEIILVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTESVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSKKLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQMSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSLTSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIERGQTHSAGTNGTGVSMEPSPPTPSFKKGLPQRKPRTSQTEAVNS
Protein: 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase (EC 1.14.15.31) (Neocarzinostatin biosynthesis protein B3) (P450 hydroxylase) (Q84HB6)
Organism: Streptomyces carzinostaticus
Function: Involved in the biosynthesis of the naphthoic acid (NA) moiety in the chromophore of the enedyine antitumor antibiotic neocarzinostatin (NCS). Catalyzes the hydroxylation at C-7 position of 2-hydroxy-5-methyl-1-naphthoate to yield 2,7-dihydroxy-5-methyl-1-naphthoate.
Interaction partners:
Sequence:
MCPYRLDPEGADTHGETARLREQGPIARVELQDGVLAWSVHDYAVAKQIMADERFSKNPRKNWPAYINGEISNGWPLITWVAMDTMATQDGADHARLRKLLLKAFTERRVESMRPHIEKTVKELLDNMAAKADDEIVDIKEMFHAELPTRLMCDLFGVPEERRAEVLAGGHKNIDTRISSEAAEANLGQWQEAISDLVEYKRHHPGDDLTSALIEARDEGSRLSDSELIGTLHLLLGAGSETLVNALAHSSLALLVDADLRKKVTSGEIPWVNVWEETLRVESPVAHLPFRYATEDFEIGGVKISKGDPLLVDFAGIGRDPAVHSDAPDEFDALRPDKTHLSFGHGVHYCLGARLAKHAWMIGIPALFERFPDMELAVRRDELKGQGSFVVNGHASLPVHLKGRAAALAR
Protein: Staphylococcal nuclease domain-containing protein (EC 3.1.31.1) (A0A140VK49)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR017179}.
Interaction partners:
Sequence:
MASSAQSGGSSGGPAVPTVQRGIIKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLARRAAATQPDAKDTPDEPWAFPAREFLRKKLIGKEVCFTIENKTPQGREYGMIYLGKDTNGENIAESLVAEGLATRREGMRANNPEQNRLSECEEQAKAAKKGMWSEGNGSHTIRDLKYTIENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPDYYLVTVMLSGIKCPTFRREADGSETPEPFAAEAKFFTESRLLQRDVQIILESCHNQNILGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLRAAERFAKERRLRIWRDYVAPTANLDQKDKQFVAKVMQVLNADAIVVKLNSGDYKTIHLSSIRPPRLEGENTQDKNKKLRPLYDIPYMFEAREFLRKKLIGKKVNVTVDYIRPASPATETVPAFSERTCATVTIGGINIAEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKKEVPIHRVADISGDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGARNLPGLVQEGEPFSEEATLFTKELVLQREVEVEVESMDKAGNFIGWLHIDGANLSVLLVEHALSKVHFTAERSSYYKSLLSAEEAAKQKKEKVWAHYEEQPVEEVMPVLEEKERSASYKPVFVTEITDDLHFYVQDVETGTQLEKLMENMRNDIASHPPVEGSYAPRRGEFCIAKFVDGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLSPAFSTRVLPAQATEYAFAFIQVPQDDDARTDAVDSVVRDIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVGLGLVKEGLVMVEVRKEKQFQKVITEYLNAQESAKSARLNLWRYGDFRADDADEFGYSR
Protein: Frizzled-4 (Fz-4) (rFz4) (CD antigen CD344) (Q9QZH0)
Organism: Rattus norvegicus (Rat)
Function: Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase (By similarity). Both pathways seem to involve interactions with G-proteins (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9ULV1}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein Wnt-5a
- LDL receptor related protein 5
- Low-density lipoprotein receptor-related protein
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Tetraspanin-12
- Protein Wnt
- Protein Wnt
Sequence:
MAWQGTGPSVRGMPGGVRLRLGLLLLQLLLLQRPALGFGDEEERRCDPIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPDSLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQSLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGNETVV
Protein: Dub protein (Duboraya) (Q0P484)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MEEHAVVKKRSVAELAGKFSCPIAHMTDAEVNKPVRRRPPRSLPLSTNNDAAQAHEEKGAETVSTRKNRNSALIEKLQANLTLSPTGPPVFPKSPGIKLVVPCFSPGSPSSPSSPPVAGTPKEEETAASFESPADGSVLMSINKGRARLSIKRRPPSRRHRKSSADEAGDEMDKTALSALENTTPNGHEGDVFVEQMPDAETLKSSKEQTEEETKPEPEKAETGDTEEPKAKAKDTKELMTAEEKEEKIEPEEKEEKSEAEAQSIDSTEETREEPITQSPTEPESKPDSTQEKEEEHKEEEDGNH
Protein: Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) (Q9H2P0)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. Chromosome {ECO:0000250|UniProtKB:Q9Z103}.
Interaction partners:
- Chromodomain-helicase-DNA-binding protein 4
- Chromobox protein homolog 3
- Chromobox protein homolog 1
- Chromodomain-helicase-DNA-binding protein 8
- Chromobox protein homolog 5
- Zinc finger and BTB domain-containing protein 14
- AT-rich interactive domain-containing protein 1A
- Nucleosome-remodeling factor subunit BPTF
- SWI/SNF complex subunit SMARCC2
- Pogo transposable element with ZNF domain
Sequence:
MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASAPSSSLSTFKDKNKNDGLKPKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPLGSNAREESSIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSMGLPPRIGSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSSVHLQQNNYGVKSVGQGYSVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRSQAPARYSLQSANASSLSSGQLKSPSLSQSQASRVLGQSSSKPAAAATGPPPGNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNPPVPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPSLAPVKRTYEQMEFPLLKKRKLDDDSDSPSFFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTADKKLNLGKEDDSSSDSFENLEEESNESGSPFDPVFEVEPKISNDNPEEHVLKVIPEDASESEEKLDQKEDGSKYETIHLTEEPTKLMHNASDSEVDQDDVVEWKDGASPSESGPGSQQVSDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATMQGDREQLKWKNSSYGKVEGFWSKDQSQWKNASENDERLSNPQIEWQNSTIDSEDGEQFDNMTDGVAEPMHGSLAGVKLSSQQA
Protein: Receptor protein-tyrosine kinase (EC 2.7.10.1) (A6QR62)
Organism: Bos taurus (Bovine)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- NRG1 protein
- Receptor protein-tyrosine kinase
- Pro-neuregulin-1, membrane-bound isoform
- Receptor protein-tyrosine kinase
- Pro-neuregulin-2, membrane-bound isoform
- Receptor protein-tyrosine kinase
- Growth factor receptor-bound protein 2
- SHC-transforming protein 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 3-kinase regulatory subunit alpha
Sequence:
MRVNRALQVLGFLLSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLHKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNEKLCHMDTIDWRDIVRDRDAEIVVKNNGKTCPPCHEACKGRCWGPGPEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQNTDCFACRLFNDSGACVRQCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKICEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTRLLRGPSEERLDIKHNRPRRDCVAEGKVCDPLCSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHQECQPMEGTVTCNGSGSDACAQCAHFRDGPHCVSSCPFGVLGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQLLPLISKTHLAMALTVVVGLAVTFLILGSTFLYWRGRKIQNKRAMRRYLERGESVEPLDPSEKANKVLARVFKETELRKLKVLGSGIFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYNEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGITPGAEPPPLTNKELEEVELEPELDLDLELEAEEENLATTLGSALSLPIGTLNRPRGSQSLVSPSSGYMPMNQGNLGEVGQESAVFGGNERYPRPASLHPMPRGRLASESSEGHVTGSEAELQEKVSMCRSQSRSPRPRGDSAYHSQRHSLLTPVTPQSPPGLEEEDVNGYVMPDTHIKGTSSREGTLSSVGLSSVLGTEDDDDEEYEYMNRRRRCSPSRPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLNPVPNMPNASTTPDEDYEYMNRRRGGGGPGGDYAAMDACPASEQGYEEMRAFQGPVLHGPQVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRI
Protein: Pumillio RNA binding protein, putative (Q4GYW2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Zinc finger protein ZFP1
Sequence:
MEVRDVNTHGGGHTAGGRPAIIKRDEQSRAIPSSSTVTNEPATRVKPERQSNATQTEADMYVPSVYHDVNNTVELQRPASAPPLSYAECPCAACAQQLSSYPAAAPMRRPPTSPYGTITTQQYNTYAAPQTPLQSHQSRNLSVHPQQRTTAAATATATAPPVPTLSRPAPSTSGDYGHYQQEPHYPPQQKEQPQQHQYPRHNVIQHQPYQLYAQPRPSQQPPPSQAPIYSKAVTAPTALDVHPLIDTTSEFLRKCAGRVVELACTPDGRSMLINALSSQDAALVDTMVREIADDLERVALDVHGCHVLRALQSYASAEHTRILVSCFTETLVLNLCTATQHTRHILESLFQRRLIDLQPIIDVLASHSRYLAATQQGCISFMHILEFCNEAQKKQLISPLVPYFAHVALDPFGNYVVQRIIQSIGLDASEYITSCFAGELLNMSCNKFGSNVVEETIKVCGGVPAVRRLLMEELISKPGALQRLVQDSFGNFVVQTFIGSITDQNELKYVNERLRPVLQNSPYAARIETRLRTALTAASKRNSQASAHCQQRQPHPNRCSQHYPTHPGTPTQLAADAPPCFAPPSSSFAHVATTAASHHQPRQQPQQQQQQQQQFMSPRYQPPPCNKAAFPQRQQNRRQSHSQPRRQPQQQHHHQHQQQVDCDDGEC
Protein: Glucose-6-phosphatase catalytic subunit 1 (EC 3.1.3.9) (Glucose-6-phosphatase) (G-6-Pase) (G6Pase) (P35576)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P35575}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Hexokinase-4
- Hexokinase HKDC1
- Hexokinase-3
- Hexokinase-1
- Hexokinase-2
- Forkhead box protein O1
- Phosphoglucomutase-1
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Fructose-bisphosphate aldolase B
- Glucose-6-phosphatase 2
Sequence:
MEEGMNILHDFGIQSTRYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLKETVGINLLWVAVVGDWFNLVFKWILFGQRPYWWVLDTDYYSNSSVPIIKQFPVTCETGPGSPSGHAMGAAGVYYVMVTSTLAIFRGKKKPTYGFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIRGIYNASLRKYCLITIFLFGFALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALNSSMYRKSCKGELSKLLPFRFACIVASLVLLHLFDSLKPPSQVELIFYILSFCKSATVPFASVSLIPYCLARILGQTHKKSL