wanglab/gogpt-training-data huggingface dataset:
Protein: Limbin (Ellis-van Creveld syndrome protein 2) (EVC2) (Q86UK5)
Organism: Homo sapiens (Human)
Function: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8K1G2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8K1G2}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8K1G2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8K1G2}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q8K1G2}. Nucleus {ECO:0000250|UniProtKB:Q8K1G2}. Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner. {ECO:0000250|UniProtKB:Q8K1G2}.
Interaction partners:
- EvC complex member EVC
- Protein smoothened
- EF-hand calcium-binding domain-containing protein 7
- IQ domain-containing protein E
- Suppressor of fused homolog
- Serine/threonine-protein kinase 32B
- Neuronal vesicle trafficking-associated protein 1
- Zinc finger protein GLI2
- Dihydropyrimidinase-related protein 1
- Syntaxin-18
Sequence:
MDPSGSRGRPTWVLAGGLLAVALALGGRGCLGASSRPRWRPLGAQPPRDPQVAPRSGPGLRIPPGRSGAGPESSTQDLPCMIWPKVECCHFKTAVEAPLGMKLDKKMEVFIPLSTSAASSGPWAHSLFAFIPSWPKKNLFKRESPITHRLYGDISREVQGTSENGVIFQKCALVSGSSEAQTARIWLLVNNTKTTSSANLSELLLLDSIAGLTIWDSVGNRTSEGFQAFSKKFLQVGDAFAVSYAATLQAGDLGNGESLKLPAQLTFQSSSRNRTQLKVLFSITAEENVTVLPHHGLHAAGFFIAFLLSLVLTWAALFLMVRYQCLKGNMLTRHRVWQYESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQPQLLALLDSATERHVDHAAESDGGAEQADVGRRRKHQSWWQALDGKLRGDLISRGLEKMLWARKRKQSILKKTCLPLRERMIFSGKGSWPHLSLEPIGELAPVPIVGAETIDLLNTGEKLFIFRNPKEPEISLHVPPRKKKNFLNAKKAMRALGMD
Protein: Protein WVD2-like 3 (Protein WAVE-DAMPENED 2-LIKE3) (Q84WL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules. Binds to, bundles and stabilizes microtubules. Required for the organization and stability of cortical microtubules in hypocotyls. Required for normal hypocotyl cell elongation. Acts as negative regulator of hypocotyl cell elongation in the light.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23653471}. Note=Associates with cortical microtubules. {ECO:0000269|PubMed:23653471}.
Interaction partners:
- At1g23060/T26J12_16
- Protein COP1 SUPPRESSOR 2
- Protein SPIRAL1
- E3 ubiquitin-protein ligase MBR2
- 65-kDa microtubule-associated protein 1
Sequence:
MDICMDKEPDGVVVYANGDSCNPNQENVSEPLLDSVSRDDANVHTELRYGEENIEVNEYDVKECTSEIPVGKPIGDDFESKDVTKSSLHAKHASKSGRGNNKTRNTVPQPFSLATEKRASSTRSFTSESLESAGLKKFPDGHSKVQSQATKVPRKPLQPKNKKLSDEEDSCSVASYATSGAKSAKSRTVVTAAPSFRSTERAEKRKEFYTKLEEKHQAMEAEKTQSEARNKEATEAALRQLRKSLRFKANPMPKFYHEGPPPKVELKKPLPTRAKSPKLGRRNPKEGNRAKGASRRHETRKTLVISKEDHDDETTRNADQINHKEMNRNLEPETAFAC
Protein: Immunoglobulin heavy constant gamma 2B (Ig gamma-2B chain C region) (P01867)
Organism: Mus musculus (Mouse)
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Interaction partners:
Sequence:
KTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGLDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQKISPDYRNMIGQGA
Protein: Pyruvate kinase (PK) (EC 2.7.1.40) (P9WKE5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Enolase
- Glucose-6-phosphate isomerase
- Pyruvate carboxylase
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL5
- Putative malate oxidoreductase
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL24
Sequence:
MTRRGKIVCTLGPATQRDDLVRALVEAGMDVARMNFSHGDYDDHKVAYERVRVASDATGRAVGVLADLQGPKIRLGRFASGATHWAEGETVRITVGACEGSHDRVSTTYKRLAQDAVAGDRVLVDDGKVALVVDAVEGDDVVCTVVEGGPVSDNKGISLPGMNVTAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEVMDRIGRRVPVIAKLEKPEAIDNLEAIVLAFDAVMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENSTAAPPLTHIPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLLELARYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV
Protein: Uncharacterized protein, isoform A (Q8IMP1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTDDLLVRRERSEDSQSSSVSIPVTPTTGGAAPAPSAPTSSLDRLRNTFRRTESISSQIFSHISTQFSNAAAAAASSEVIDGTTTYPYPDEPAPPVVPVAPDTVASASASSPSPSKLKAKRLKRARDTAEIERSNLVNICKLVVKELLEQSLRYGRMLDSDHLPLQHFFIVIEHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAWLRIALMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLDSQQGVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQECEDELTQKGEMVSRLQTKASQIGNILQSLEKKYESKLIDQQHHGPGSGSGTGAGTGAGNGAIGGDRSPNTRRQQNLEKFEALTKKHKQDAGPPMKRMHLKMDAFPPFDPSKYRKSPRQPDAPNTEELQQSKDAKTPTSAKSLNDELAEAAAAVTQHFGVDASQSDYVLCREQAADGET
Protein: Sensor histidine kinase component HK2 (EC 2.7.13.3) (O07777)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Member of the three-protein two-component system HK1/HK2/TcrA. HK2 transfers its phosphoryl group to TcrA.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Transcriptional regulatory protein TcrA
- Sensor histidine kinase component HK1
- Transcriptional regulatory protein TrcR
- Multifunctional 2-oxoglutarate metabolism enzyme
- Probable transcriptional regulatory protein TcrX
- Response regulator MprA
- 3-methyl-2-oxobutanoate dehydrogenase subunit beta
- Transcriptional regulatory protein PrrA
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
- Possible two component system response transcriptional positive regulator PhoP
Sequence:
MALVLAAAGAVTVVQFRDAAHEADPDGALRGLTDDITADLVRELVTILPIVLVIAAVAAYLLSRAALRPVDRIRAAAQTLTTTPHPDTDAPLPVPPTDDEIAWLATTLNTMLTRLQRALAHEQQFVADASHELRTPLALLTTELELRCAGPDPPTS
Protein: Nuclear autoantigenic sperm protein (E9PPQ8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAMESTATAAVAAELVSADNLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEE
Protein: FACT complex subunit ssrp1-B (Facilitates chromatin transcription complex subunit ssrp1-B) (HMG box-containing protein 3) (Structure-specific recognition protein 1-B) (O01683)
Organism: Caenorhabditis elegans
Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity). In embryos, may function redundantly with hmg-4 to promote cell cycle progression and development of the anterior pharynx. In the germline, acts non-redundantly with hmg-4 to play a role in oocyte development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:30336114}. Chromosome {ECO:0000250|UniProtKB:Q08945}.
Interaction partners:
- FACT complex subunit spt-16
- Transcription elongation factor SPT5
- Suppressor of Ty 6 homolog
- RNA polymerase-associated protein CTR9
- RNA polymerase-associated protein RTF1 homolog
- RNA polymerase-associated protein LEO1
- Transcription elongation factor SPT4
- RNA polymerase II-associated factor 1 homolog
- Cell division cycle protein 73
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MTELKFKGVYVEDIGHLTCGTLTLTENSINFIGDKGGKSVYITGTDVDKLKWQKLGNKPGLRVGLSDGGAHRFGGFLDDDLQKIQSFTSSNWSKSINQSNLFINGWNYGQADVKGKNIEFSWENEPIFEIPCTNVSNVIANKNEAILEFHQNEQSKVQLMEMRFHMPVDLENEEDTDKVEEFKKAVLAYAGLEAETEQPICLLTDILCTTPRGRYDIKVYPTSIALHGKTYDYKIPVKTINRLFLVPHKDGRQVYFVLSLNPPIRQGQTHYSYLIFEFGKDEEEDLELSLTDEQLDYFNGNLQREMTGPIYETISILFKSICNLKVTVPGRFLGSSGTPAIQCTHRQNLGLLYPMEKGFLFIQKPVMYIRFEEISSCHFARSDSGTVTRTFDFEIDLKTGSSLTFSAMDKEENNKLFDYLNKKEIKIRNSHRIDNKSAGYGSSDEDDIDPYKSTVKAEGREQDDDSDDESTDEDYDLDKDMKKQKNDKDSSEGSGSEPDDEYDSGSEKDASGTGESDPDEENIEPKKKESKEKKNKREKKEKPVKEKAVKKGKKTKDPNEPKRATTAYIIWFNANRNSMKEDGDTLGDVAKKAGAKWKSMSADDKKEWNDKAAQDKARYEAEMKEYKKNGGGVEKASGPSTKKSSDQSPGKQFKSKEHISDTDDSDDDEPLKAKKDESDAASESSGESD
Protein: CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9) (P21926)
Organism: Homo sapiens (Human)
Function: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation. Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P40240}. Note=Present at the cell surface of oocytes. Accumulates in the adhesion area between the sperm and egg following interaction between IZUMO1 and its receptor IZUMO1R/JUNO. {ECO:0000250|UniProtKB:P40240}.
Interaction partners:
- Prostaglandin F2 receptor negative regulator
- Immunoglobulin superfamily member 8
- CD81 antigen
- Tumor susceptibility gene 101 protein
- CD63 antigen
- Integrin beta-1
- CD44 antigen
- CD82 antigen
- Proheparin-binding EGF-like growth factor
- Integrin alpha-3
Sequence:
MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV
Protein: Uncharacterized protein (Q38EH2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
Sequence:
MNFGNMTLGGATATFGGQSNPLCNYTSSLAKKFVYKEINKVYYPLRRHVFRLKVRTAAEIRFNDVVKAYMKDKMTFKKGCYAATITNTVELDHMGSIIPKDEYEVRRLTSYMTSKKMSNDYKKHMQELWTRVLFVCESTNLVGVTENATHQNSRPGTDEEFMAIIWYSTFASTLFAFVITLLVWWYRYGQAPQYAEMK
Protein: Unconventional myosin-Ie (Unconventional myosin 1E) (E9Q634)
Organism: Mus musculus (Mouse)
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain (By similarity). Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated ve (By similarity)sicles. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19005011}. Cell junction {ECO:0000269|PubMed:19005011}. Cytoplasmic vesicle {ECO:0000305|PubMed:19005011}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:19005011}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19005011}. Note=In podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with F-actin (By similarity). Detected in cytoplasmic punctae. {ECO:0000250}.
Interaction partners:
- Synaptojanin-1
- Actin nucleation-promoting factor WASL
- Actin nucleation-promoting factor WAS
- Unconventional myosin-Ic
- WAS/WASL-interacting protein family member 2
Sequence:
MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEVEMYQGAAQYENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKQSLGITSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFSEEQTLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIESKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPVWRGDEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKTWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEERPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGVVKEVLKRRIEVERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPKNSRPTRRNTVTSRGYPGGTKNNYPMRAAPAPPGCHQNGVIRNQFVPPPHAFGNQRSNQKSLYTSMARPPLPRQQSTGSDRLSQTPESLDFLKVPDQGVAGVRRQTSSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI
Protein: Oligodendrocyte transcription factor 1 (Oligo1) (Oligodendrocyte-specific bHLH transcription factor 1) (Q9JKN5)
Organism: Mus musculus (Mouse)
Function: Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- DNA-binding protein inhibitor ID-4
- DNA-binding protein inhibitor ID-2
- Transcription factor SOX-10
- Homeobox protein Nkx-2.2
- Achaete-scute homolog 1
- Glial fibrillary acidic protein
- Oligodendrocyte transcription factor 2
- Myelin basic protein
- Myelin regulatory factor
- 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Sequence:
MYYAISQARVNAAPATMLRPQRPGDVQLGASLYELVGYRQPPISSSSSSSSSTASLLPKPAREKAEAPLAEPRGPAPESGGARADAKEEQQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGDGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPETLRPTKYLSLALDEPPCGQFSLPAGGAGSPGLCSCAVCKFPHLVPAGLGLAAVQAQFSK
Protein: Sodium/potassium-transporting ATPase subunit beta-2 (Sodium/potassium-dependent ATPase subunit beta-2) (P13638)
Organism: Rattus norvegicus (Rat)
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Subcellular location: Cell membrane; Single-pass type II membrane protein.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit alpha-2
- Sodium/potassium-transporting ATPase subunit alpha-1
- Sodium/potassium-transporting ATPase subunit gamma
- Sodium/potassium-transporting ATPase subunit alpha-3
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit alpha-4
- Sodium/potassium-transporting ATPase subunit beta-3
- Phospholemman
- Protein ATP1B4
- cAMP-dependent protein kinase catalytic subunit beta
Sequence:
MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNISDTESWDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDPTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTCVGKKDEDAENLGHFIMFPANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAARVAFKLRINKA
Protein: Ubinuclein-2 (AtUBN2) (Ubiquitously expressed nuclear protein 2) (F4I700)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be required for replication-independent chromatin assembly.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:25086063}. Nucleus, nucleolus {ECO:0000269|PubMed:25086063}. Note=Localized at rDNA loci in the nucleolus. {ECO:0000269|PubMed:25086063}.
Interaction partners:
- Calcineurin-binding protein 1
- Thioredoxin Y1, chloroplastic
- Dormancy-associated protein homolog 3
- Capsid-like protein
- Homogentisate solanesyltransferase, chloroplastic
Sequence:
MEDEPKLPTDDGPTFNESCKISSEILTAGDRKLLKVELLKEETTLVSWKKLMDEASKENGGLFVSAPERLLNANPNLEFRLAPGAQTENEMVNQPHPNRLNSVIAKIERLYMGKDGSDGEELDGAPDDDDYDTEDSFIDDAELDEYFEVDNSPIKHDGFFVNRGKLERIEPSATSNQQQPKKRRRKESAKPCGDVVDVSRKRAKMAKTAGGKDQSASPGPSSKKISNDSKTVQDSFSPLKAQNGNDSLVLENVKHTDKANHQPMNATSPKSKAAGSSGPLHPKCSSKSVHEQSNSPPGKSRPNVSAKSAVVRQQVNNGMPDLDIATESKTSIQISKKSGSNGRPKYSTLEKAIRNLEKLVAESRPPAATENQDADISSQAVKRGLPGDVKLHLAKVARIAYASQGEISGELINRLMGIVGHLIQIRSLKRNLKIMIDSIVTANREKDTRFQRIKSEITEMLKTQVPLVESQETNQEAGTSDDFQDVGSLGKSPVKKFVMDVALEEKLCDLYDVFVEGMDEHSGSQIRKLYSDLAQLWPNSLVDNHEIRRAICREKERRRALEGNIGKEMDQTKITKKKQTQLVPKSEGITYPDKTSGVEVKASVVLTATTTSLVDCQPAADSSFERSKQQHEKLKRTSSLSNPAAEGKKVRRKTEPALEETHLPAEKPLVLALKRQTHLKSKTHKQVQVHPQSKAHKQAQVHPKAKTQTPPDLNLPS
Protein: Cytosolic Fe-S cluster assembly factor CFD1 (Cytosolic Fe-S cluster-deficient protein 1) (Ribosomal export protein 19) (P40558)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Nucleotide binding/hydrolysis seems to be critcal for loading of Fe-S clusters onto CFD1 and NBP35. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03039, ECO:0000269|PubMed:12970194}.
Interaction partners:
- Cytosolic Fe-S cluster assembly factor NBP35
- Cytosolic Fe-S cluster assembly factor NAR1
- Fe-S cluster assembly protein DRE2
- NADPH-dependent diflavin oxidoreductase 1
- MIP18 family protein YHR122W
- Iron-sulfur clusters transporter ATM1, mitochondrial
- DNA repair/transcription protein MET18/MMS19
- Cytosolic iron-sulfur protein assembly protein 1
- Protein YAE1
- Cysteine desulfurase, mitochondrial
Sequence:
MEEQEIGVPAASLAGIKHIILILSGKGGVGKSSVTTQTALTLCSMGFKVGVLDIDLTGPSLPRMFGLENESIYQGPEGWQPVKVETNSTGSLSVISLGFLLGDRGNSVIWRGPKKTSMIKQFISDVAWGELDYLLIDTPPGTSDEHISIAEELRYSKPDGGIVVTTPQSVATADVKKEINFCKKVDLKILGIIENMSGFVCPHCAECTNIFSSGGGKRLSEQFSVPYLGNVPIDPKFVEMIENQVSSKKTLVEMYRESSLCPIFEEIMKKLRKQDTTTPVVDKHEQPQIESPK
Protein: MA3 DOMAIN-CONTAINING TRANSLATION REGULATORY FACTOR 3 (EIN2 C-terminus interacting protein 1) (MA3 domain-containing protein 5) (Q8W4Q4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in target of rapamycin (TOR)-regulated translation control, especially under energy-deficient conditions. Involved in the regulation of the ethylene-mediated signaling pathway. Involved in salt stress responses. Reduced cotyledons size and early flowering.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Cytoplasm, cytosol {ECO:0000269|PubMed:21631530, ECO:0000269|PubMed:29084871}.
Interaction partners:
- F-box protein At5g18160
- Ethylene-insensitive protein 2
- Probable splicing factor 3A subunit 1
- Protein EIN4
Sequence:
MEGFLTDQQREMMKVATQTADDLPPSQKPHSVLLEHLPKPSGGGKASGASNAVKHRRSHAGRSIRSKKDGGGGKGNWGKLIDTDGDYHIDPNDPNYDSGEEPFELVGATLSDPLDDYKKAAASIINEYFSTGDVDVAAADLIELGSSEYHPYFIKRLVSVAMDRHDKEKEMASVLLSALYADVINPNQIRDGFVLLLESADDFVVDIPDAVNVLALFLARAVVDDILPPAFLPRAAKALPITSKGYQVVQTAEKSYLSAAHHAELVERRWGGQTRTTVEEVKKKIADILNEYVETGETYEACRCVRELGVSFFHHEVVKRALVTALENHAAEAPVLKLLNEAASENLISSSQMVKGFSRLRESLDDLALDIPSARTKFGLIVPKAVSGGWLDASFGYPSGECGRQQNEDEKLKRFKEDIVTIIHEYFNSDDIPELIRSLEDLGAPEYNPIFLKKLITLALDRKNHEKEMASVLLSSLHIEMFTTEDVADGFVMLLESAEDTALDILDASNELALFLARAVIDDVLAPFNLEEISSKLRPNSSGTETVKMARSLIFARHAGERLLRCWGGGSGWAVEDAKDKISNLLEEYESSGLVSEACKCIHELGMPFFNHEVVKKALVMGMEKKKDKMMLDLLQESFSEGLITTNQMTKGFTRVKDGLEDLALDIPNAKEKFNDYVEYGKKNGWVSSSFLTSLTEDANVG
Protein: Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31) (Q9EST5)
Organism: Mus musculus (Mouse)
Function: Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription. Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (By similarity). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (By similarity). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (By similarity). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92688}. Note=Accumulates in the nuclei at the S phase. {ECO:0000250|UniProtKB:Q92688}.
Interaction partners:
- Exportin-1
- Histone H2A.Z
- Acidic leucine-rich nuclear phosphoprotein 32 family member A
- Iron-sulfur cluster assembly enzyme ISCU
Sequence:
MDMKRRIHLELRNRTPAAVRELVLDNCKAMDGKIEGLTDEFVNLEFLSLISVGLFSVSDLPKLPKLKKLELSENRIFGGLDRLAEELPSLTHLNLSGNNLKDISTLEPLKRLDCLKSLDLFGCEVTNRSDYRETVFRLLPQLSYLDGYDREDQEAPDSDVEVDSVEEAPDSDGEVDGVDKEEEDEEGEDEEEEEDEDGEEEEDEDEEDEDEDEDVEGEDDEDEVSGEEEEFGHDGEVDEDEEDEDEDEDEEEEESGKGEKRKRETDDEGEDD
Protein: Alpha/beta-Hydrolases superfamily protein (Putative epoxide hydrolase) (Q9M9W5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEGIDHRMVSVNGITMHIAEKGPKEGPVVLLLHGFPDLWYTWRHQISGLSSLGYRAVAPDLRGYGDSDSPESFSEYTCLNVVGDLVALLDSVAGNQEKVFLVGHDWGAIIGWFLCLFRPEKINGFVCLSVPYRSRNPKVKPVQGFKAVFGDDYYICRFQEPGKIEGEIASADPRIFLRNLFTGRTLGPPILPKDNPFGEKPNPNSENIELPEWFSKKDLDFYVSKFEKAGFTGGLNYYRAMDLNWELTAPWTGAKIQVPVKFMTGDFDMVYTTPGMKEYIHGGGFAADVPTLQEIVVIEDAGHFVNQEKPQEVTAHINDFFTKLRDNNKSF