wanglab/gogpt-training-data huggingface dataset:
Protein: Copper transport protein CTR2 (Copper transporter 2) (P38865)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:15494390}; Multi-pass membrane protein {ECO:0000269|PubMed:15494390}.
Interaction partners:
- Copper transport protein CTR3
- Cytochrome c oxidase copper chaperone
- Metal-binding activator 1
- Low-affinity Fe
- Iron transport multicopper oxidase FET3
- Superoxide dismutase
- Copper-transporting ATPase
- Copper transport protein CTR1
- Ferric reductase transmembrane component 6
- Copper chaperone ATX1
Sequence:
MDDKKTWSTVTLRTFNQLVTSSLIGYSKKMDSMNHKMEGNAGHDHSDMHMGDGDDTCSMNMLFSWSYKNTCVVFEWWHIKTLPGLILSCLAIFGLAYLYEYLKYCVHKRQLSQRVLLPNRSLTKINQADKVSNSILYGLQVGFSFMLMLVFMTYNGWLMLAVVCGAIWGNYSWCTSYSPEIDDSSLACH
Protein: Glycerol kinase (F4JTL0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Argininosuccinate synthase, chloroplastic
- Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic
- Diaminopimelate epimerase, chloroplastic
- Allantoinase
- Dihydropyrimidinase
- Ornithine transcarbamylase, chloroplastic
- Dihydroorotate dehydrogenase
- Dihydrodipicolinate reductase-like protein CRR1, chloroplastic
- Dihydropyrimidine dehydrogenase
- Arginine biosynthesis bifunctional protein ArgJ
Sequence:
MLSSSGSSLLWRSRTHVPAPPPRSSPPLKALSFPFSSSLWFIHRTTISPLSCSAESSSEIALAQSQPAPDFNPWSEFAQNVSGEWDGFGADFTCEGQPLELPESVVPEAFREWEVKVFDWQTQCPTLAQPNSLSFLYKSIKLLPTVGCEADAATRYSIDQRIIGGGKSSALAFSYSVTGSYVAVWPLRNNQLEVEHCLINPKDKESRVRIFQVVSLAETTNMSLQSVKVFCEQWYGPFRDGDQLGGCAIRSSGFAATPTTAASVVTGSWRVLLATTSFHASDFGCIQQVTGEKVIEIVREENDLLLLPQELWCSLQQGKDRERVFSVGWVFEPGHAITSSCVFSSDSKLKEVTMGRETALSDSLC
Protein: Asparagine--tRNA ligase (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (O51128)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00534}.
Interaction partners:
- DNA polymerase I
- Aspartyl/glutamyl-tRNA
- Glutamyl-tRNA
- Methionine--tRNA ligase
- Glutamate--tRNA ligase
- Proline--tRNA ligase
- Isoleucine--tRNA ligase
- Glutamyl-tRNA
- Arginine--tRNA ligase
- Leucine--tRNA ligase
Sequence:
MFASIKDILKNPILNSNVTINGWIRTKRSNGKIGFIEINDGSTLKGIQAVINEEENQFSEKDLKKLTTGTSISLTGLLVESPAKGQNYEIKTHSFNVIGETDPETYPLQKKRHSFEFLREIPHLRIRTNTFGAIARVRNKISYKIHEYFQKNGFFYINTPIITSNDGEGAGEMFRVSTLKFNKLNNALSNIDFKDDFFGKEAFLSVTGQLHGEAYAMALSKIYTFGPTFRAENSNTTRHASEFWMIEPEMAFYKLNDNIALAEDLLKYLLSSILNECSQDMDFLENYIEKGLIKKLENVINSNFEVITYTKAIEILENSKKNFEIKPYWGIDLQTDHERYLTEETFKKPVVVIDYPKNFKAFYMKANKDNKTVKGMDILVPKIGEIIGGSEREDDLQKLENRIKELNLNIEHLNWYLDLRRFGSAPHSGFGLGLERLVQYSTGISNIRDSIPFPRTPKNLYF
Protein: Hydrolase C26A3.11 (EC 3.5.-.-) (Q10166)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- NADP-specific glutamate dehydrogenase
- Probable NAD-specific glutamate dehydrogenase
- Spermidine synthase
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Glutamate synthase
- Alpha-1,2-galactosyltransferase
- Large ribosomal subunit protein eL31
- Bis
- Malate dehydrogenase, mitochondrial
Sequence:
MNSKFFGLVQKGTRSFFPSLNFCYTRNIMSVSASSLVPKDFRAFRIGLVQLANTKDKSENLQLARLKVLEAAKNGSNVIVLPEIFNSPYGTGYFNQYAEPIEESSPSYQALSSMAKDTKTYLFGGSIPERKDGKLYNTAMVFDPSGKLIAVHRKIHLFDIDIPGGVSFRESDSLSPGDAMTMVDTEYGKFGLGICYDIRFPELAMIAARNGCSVMIYPGAFNLSTGPLHWELLARARAVDNEMFVACCAPARDMNADYHSWGHSTVVDPFGKVIATTDEKPSIVYADIDPSVMSTARNSVPIYTQRRFDVYSEVLPALKKEE
Protein: E3 SUMO-protein ligase NSE2 (E3 SUMO-protein transferase NSE2) (Non-structural maintenance of chromosomes element 2 homolog) (Q8I8I1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDFVSDFSDGGKIKKLLEQSVEQSVEHAVNVVHMKIKHQSLNKAMNQVKNSSATIEEFEEVWKERSKAVEQKRINVKNLHEFKNFVKAVESAAGQAGAEVNDQANGTAYDEDLIMEDSGSEVFSFYDPWSKALIKNPMRNKMCGHIYDRDSVMPIIMDRIGIRCPVLGCANLCYIQPDHLVQDANVQQKIQQSMSNAIVDVTASEEDDE
Protein: Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) (P30530)
Organism: Homo sapiens (Human)
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
Subcellular location: Cell membrane {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}.
Interaction partners:
- Growth arrest-specific protein 6
- Vitamin K-dependent protein S
- Proto-oncogene tyrosine-protein kinase Src
- SHC-transforming protein 1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- Growth factor receptor-bound protein 2
- GRB2-associated-binding protein 1
- Interferon alpha/beta receptor 1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Tyrosine-protein kinase JAK2
Sequence:
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Protein: E3 SUMO-protein ligase SIZ1 (EC 2.3.2.-) (E3 SUMO-protein transferase SIZ2) (SAP and Miz-finger domain-containing protein 1) (Ubiquitin-like protein ligase 1) (Q04195)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as an E3 ligase mediating SUMO/Smt3 attachment to septins and PCNA. May be involved in chromosome maintenance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16109721}. Nucleus {ECO:0000269|PubMed:11572779, ECO:0000269|PubMed:16109721}. Bud neck {ECO:0000269|PubMed:11572779, ECO:0000269|PubMed:11587849, ECO:0000269|PubMed:12761287, ECO:0000269|PubMed:16109721}. Note=Present at the bud neck in early M-phase. {ECO:0000269|PubMed:11587849}.
Interaction partners:
- SUMO-conjugating enzyme UBC9
- Ubiquitin-like protein SMT3
- Proliferating cell nuclear antigen
- E3 SUMO-protein ligase MMS21
- Postreplication repair E3 ubiquitin-protein ligase RAD18
- E3 SUMO-protein ligase SIZ2
- DNA repair protein RAD5
- Ubiquitin-like-specific protease 1
- DNA repair and recombination protein RAD52
- Ubiquitin-like-specific protease 2
Sequence:
MINLEDYWEDETPGPDREPTNELRNEVEETITLMELLKVSELKDICRSVSFPVSGRKAVLQDLIRNFLQNALVVGKSDPYRVQAVKFLIERIRKNEPLPVYKDLWNALRKGTPLSAITVRSMEGPPTVQQQSPSVIRQSPTQRRKTSTTSSTSRAPPPTNPDASSSSSSFAVPTIHFKESPFYKIQRLIPELVMNVEVTGGRGMCSAKFKLSKADYNLLSNPNSKHRLYLFSGMINPLGSRGNEPIQFPFPNELRCNNVQIKDNIRGFKSKPGTAKPADLTPHLKPYTQQNNVELIYAFTTKEYKLFGYIVEMITPEQLLEKVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSLQCPISYTRMKYPSKSINCKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISEFVDDILQNCQKNVEQVELTSDGKWTAILEDDDDSDSDSNDGSRSPEKGTSVSDHHCSSSHPSEPIIINLDSDDDEPNGNNPHVTNNHDDSNRHSNDNNNNSIKNNDSHNKNNNNNNNNNNNNNDNNNSIENNDSNSNNKHDHGSRSNTPSHNHTKNLMNDNDDDDDDRLMAEITSNHLKSTNTDILTEKGSSAPSRTLDPKSYNIVASETTTPVTNRVIPEYLGNSSSYIGKQLPNILGKTPLNVTAVDNSSHLISPDVSVSSPTPRNTASNASSSALSTPPLIRMSSLDPRGSTVPDKTIRPPINSNSYTASISDSFVQPQESSVFPPREQNMDMSFPSTVNSRFNDPRLNTTRFPDSTLRGATILSNNGLDQRNNSLPTTEAITRNDVGRQNSTPVLPTLPQNVPIRTNSNKSGLPLINNENSVPNPPNTATIPLQKSRLIVNPFIPRRPYSNVLPQKRQLSNTSSTSPIMGTWKTQDYGKKYNSG
Protein: 26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) (P62192)
Organism: Mus musculus (Mouse)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:P62191}; Lipid-anchor {ECO:0000250|UniProtKB:P62191}.
Interaction partners:
- 26S proteasome regulatory subunit 7
- Proteasome subunit alpha type-5
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome non-ATPase regulatory subunit 5
- 26S proteasome regulatory subunit 10B
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 3
- 26S proteasome regulatory subunit 6B
- 26S proteasome regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 13
Sequence:
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
Protein: G-protein coupled receptors family 1 profile domain-containing protein (H2FLI4)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MFRNYTDSVQEMVLRAIDSIRDSVINASSAVSTTTLPPLDIPMTSMKPPSIIPTVELVLGTITYLVIIAMTVVGNTLVVVAVFSYRPLKKVQNYFLVSLAASDLAVAIFVMPLHVVTFLAGGKWLLGVTVCQFFTTADILLCTSSILNLCAIALDRYWAIHNPINYAQKRTTKFVCIVIVIVWILSMLISVPPIIGWNNWQENMMEDSCGLSTEKAFVVFSAAGSFFLPLLVMVVVYVKIFISARQRIRTNRGRSALMRIQNAEGDDDYRKMSIKRASVESARTSSRVGEKTPLVIADGQTTVTTLAAHSNPNPTAVLRKREKISVAKEKRAAKTIAVIIFVFSFCWLPFFVAYVIRPFCETCKLHAKVEQAFTWLGYINSSLNPFLYGILNLEFRRAFKKILCPKAVLEQRRRRMSAQP
Protein: Calcineurin-like metallo-phosphoesterase superfamily protein (A8MQN4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Phosphatidylinositol-glycan biosynthesis class X-like protein
- Mannosyltransferase APTG1
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
- Polynucleotide 3'-phosphatase ZDP
- GPI mannosyltransferase 1
- Dol-P-Man:Man
- GDP-Man:Man
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
- Dol-P-Man:Man
Sequence:
MKHHHKLTVALCLIWAATILYGEMFAFWVPSLFTCSWPHHKSDGVESDGNFTKVAIVTDPQLMDKTSFRLSSKTLALELAQFYTDINMRRSFFRSVLPFKPDVVLFLGDYFDGGPFLSEEEWQESLNRLKHVFGLNSEGRVGDIPTFYIPGNHDIGYSRVASHKQGVIDRYEKVFGVRNRRFMIGNVEFISIDAQAIDGNSKKDLASEVWKFVQNVSTDAQSHPRVLLTHIPLYRPDQTPCGPHRGSSVIDQRFWRHSQDQEVIYQNYITPESSTKLLELIKPILVLSGHDHDQCTVIHKSKAGSVTEHTLGTVSWQQGNIHPSFMLLSVPKAFHRNSSDPDKMLHTQLCFLPSQLFIYMWYLSLFVMSLLALLLWPNHGISFLNNAADCISNVMKSSFLSSVTKEKNEDENCEYEMVWDAEGSMHLVKKALQTPVKRQSDKPLVEKGNAVMRSAARKNASEQIELVMDSDVNASAGGSDPLMRSASKSRTKLVIQRVIRTIMMVIVIAALNVPIYMMLLFKDWIEQE
Protein: Nuclear receptor subfamily 6 group A member 1 (Germ cell nuclear factor) (GCNF) (hGCNF) (Retinoid receptor-related testis-specific receptor) (RTR) (hRTR) (Q15406)
Organism: Homo sapiens (Human)
Function: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:26769970}.
Interaction partners:
- Mitochondrial ubiquitin ligase activator of NFKB 1
- V-type proton ATPase 116 kDa subunit a 2
- Protein Cripto
- DNA
- DNA
- Ubiquitin-conjugating enzyme E2 D2
- Nuclear receptor corepressor 1
Sequence:
MERDEPPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLPQQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSVGKE
Protein: BIP1 protein (Bip1, isoform A) (Q9V457)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein tramtrack, alpha isoform
- E3 ubiquitin-protein ligase sina
Sequence:
MTNTITTLRICQAVSLNPSANGPEPVLPPSSRICLMGCQDVKPNDLRRFPVHDTDRCNHWLRHFGVSYKLVDQLGGLQKLRICSRHFSQRQEMAKTRIKMTPLRKSSSSKGIVLPINAAGGSVIAGALAGGGGAGTGSGAVKSAVASSTTIELVESPNRHQAKKPNTGIMPMPQRSHSISSSASSDVLSINSDYEASLPLSALEDSQNGLNRLENGQAKKRKLYVITEKSDETKGQTLETNGQPKKRKMFVVVEQDKDVAGKKLMIMADKPQTNLTQHLEKLLPELLNRIQDKEQKQIKPAPVVTKAKPVVNNPRPHITLPPKKNPTNFAKITSTPSSVPSSIQMPLPIQNTKILKSENSELTMNSDEIETNINLSPDFRFLMKILPKLEQLPEPHKQNVKRSIQIFVEKSYSIYGNKD
Protein: Mediator of RNA polymerase II transcription subunit 4 (Mediator complex subunit 4) (Q9CQA5)
Organism: Mus musculus (Mouse)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 9
- Mediator of RNA polymerase II transcription subunit 26
Sequence:
MAASSSGEKEKERMGGVSGMAGLGSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQLEEENQVLELLIHRDGDFQELMKLALNQGKVHHEMQALEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTSGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSSDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD
Protein: Type II secretion system protein I (T2SS minor pseudopilin I) (E0SLF9)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004377, ECO:0000256|RuleBase:RU368030}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004377, ECO:0000256|RuleBase:RU368030}.
Interaction partners:
- Type II secretion system protein J
- Type II secretion system protein K
- Type II secretion system protein L
- Type II secretion system protein H
- Type II secretion system protein C
- Type II secretion system protein M
- Type II secretion system core protein G
- Secretin OutD
- General secretion pathway protein I
- Type II secretion system protein F
Sequence:
MKQQGMTLLEVMVALVIFALAGLTVLKTTAQQANGLGRLEEKTFALWIAENQQAAMRLEKQWPQTQWVDGEVNFAGSVWFWRIQGVATADTQVRAIDVEVRHERDSRAADAILRSYQVQPGEPAQ
Protein: GH06740p (Leucine-rich repeat 47, isoform A) (Leucine-rich repeat 47, isoform B) (Q9VKU0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cullin-2
- Elongin-B
- Elongin-C
- DNA replication licensing factor Mcm7
- LD46023p
- RING-box protein 1B
- RING-box protein 1A
- Chromosome transmission fidelity 4
- DNA replication complex GINS protein PSF1
- DNA replication licensing factor Mcm3
Sequence:
MKILCEVQVVNRATQTNKTPRPVKSTLAIGYKQSARDANGNTKKELEMVLFSGQNKTGNRYKVKDNIHVVHTKFVLDGKTTIGFIQPPDNLLIKCDPIQLKGFLQTLKLGMDGKDAINLRLNINAATAIPQKAQPQVRMVISKRSEYPIKGFPRTLKSLTINNSQLVKLSFEICTLRNLTKLDVSGNKLTKIPSELGRLPLTSLHLGNNLLGTQNDWCWLRGTKLCQSLGELDLSGNGLTYFPPPLVKFESLVSLNLNNNLLSRLPFAIRRMKALRKLYVCSNELESLPSAVEDLRIDLLDVWGNCFKEFNADAAQQMYLQKAASNSPQPLWLLGARAVDKYMLPLSAGSIPAVLIDLIREAPRCPCGELCYAQRKEDLFQRVVQPKFITVKNLTYSREHQIYADVVLCDSRCSASAELKLLFNIIFS
Protein: Ras-related protein Rab-10 (Q9U1W9)
Organism: Caenorhabditis elegans
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
- Trafficking protein particle complex subunit 3 homolog
- Rab-GAP TBC domain-containing protein
- Trafficking protein particle complex subunit 8
- Rab GDP dissociation inhibitor
- NADH-ubiquinone oxidoreductase chain 4
- Ras-related protein Rab-18
- Trafficking protein particle complex subunit
- Complex 1 LYR protein domain-containing protein
- Probable geranylgeranyl transferase type-2 subunit beta
- Trafficking protein particle complex subunit
Sequence:
MDNDDGFDYLFKIVLVGDMGVGKTCVVQRFRNGTFVDRQGTTIGVDFTMKTLVVDGKRVKLQIWDTGGQERFRTITQSYYRSANGIVLCYDITCKQSFGSLQRWIDDVSKFAAPNVVKLLIGTKCDLEDQRAIEAEEAEMLQRANGMFAMLETSAKGNVNVDNAFLELATILKRQYDQGVVEQGSSGTFQLGSGGTTALGSPWQRCCQYT
Protein: Protection of telomeres protein 1 (mPot1) (POT1-like telomere end-binding protein) (Q91WC1)
Organism: Mus musculus (Mouse)
Function: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000250}. Note=Colocalizes with telomeric DNA. {ECO:0000250}.
Interaction partners:
- Telomeric repeat-binding factor 1
- TERF1-interacting nuclear factor 2
- Telomeric repeat-binding factor 2
- Tripeptidyl-peptidase 1
- Adrenocortical dysplasia protein
- Telomeric repeat-binding factor 2-interacting protein 1
- CST complex subunit CTC1
- CST complex subunit STN1
- Protection of telomeres protein 1
- Telomerase reverse transcriptase
Sequence:
MSLVSTAPYTYTPLNLLKEGTIANVYGVVKFFKPPYVSKGTDYCSVVTIVDQTNVKLTCMLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKMVEALRVWASKHISASSTLVQLCDAQPMQYYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTFEGDLSHIERLQSLVVDILVYDNHVQVARSIEVGCFLRLYSLHTKLQPGNSETSSSESLRLEFHLHGGTSYGRGIRVLPDTSPCVDQLKKALEGANLPVTETSTGICQSENGDSSALSNSGSGAVSPYEEERCQQVSATILTNHQHLEKTPLCAILTQKAPQQYRVRAKLRSYLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPDIKLKATSLYYSKVWTTEDQGGRQVAVHFVKNNGILPASSECLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTLSAPFLIQGKVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTLDDGTGVLEAYLKDSEHFFKIPASEVLTDDDLQRSLETIMDMICPPGIKVDAYPWLECLLKSYNVTIGTERRICYQIFDTTVAENVV
Protein: Transcription antitermination protein RfaH (P0AFW0)
Organism: Escherichia coli (strain K12)
Function: Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains. Enhances expression of several operons involved in synthesis of lipopolysaccharides, exopolysaccharides, hemolysin, and sex factor. Also negatively controls expression and surface presentation of AG43 and possibly another AG43-independent factor that mediates cell-cell interactions and biofilm formation.
Interaction partners:
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit beta
- Transcription termination/antitermination protein NusG
- DNA-directed RNA polymerase subunit alpha
- Transcription termination factor Rho
- Small ribosomal subunit protein uS10
- DNA-directed RNA polymerase subunit omega
- Uncharacterized protein YaeQ
- Large ribosomal subunit protein uL11
- Lipopolysaccharide heptosyltransferase 3
Sequence:
MQSWYLLYCKRGQLQRAQEHLERQAVNCLAPMITLEKIVRGKRTAVSEPLFPNYLFVEFDPEVIHTTTINATRGVSHFVRFGASPAIVPSAVIHQLSVYKPKDIVDPATPYPGDKVIITEGAFEGFQAIFTEPDGEARSMLLLNLINKEIKHSVKNTEFRKL