wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome P450 6a8 (EC 1.14.-.-) (CYPVIA8) (Q27593)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- NADPH--cytochrome P450 reductase
- NADPH-dependent diflavin oxidoreductase 1
Sequence:
MALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVAVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKVETV
Protein: ABC transporter G family member 11 (ABC transporter ABCG.11) (AtABCG11) (Protein CUTICULAR DEFECT AND ORGAN FUSION 1) (Protein DESPERADO) (Protein PERMEABLE LEAVES 1) (White-brown complex homolog protein 11) (AtWBC11) (Q8RXN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the cuticle, root suberin and pollen coat development by controlling cutin and maybe wax transport to the extracellular matrix. Involved in developmental plasticity and stress responses. Together with ABCG9 and ABCG14, required for vascular development by regulating lipid/sterol homeostasis. May be a transporter of lignin precursors during tracheary element differentiation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17727615, ECO:0000269|PubMed:17951461, ECO:0000269|PubMed:17971336, ECO:0000269|PubMed:17989085, ECO:0000269|PubMed:20870961, ECO:0000269|PubMed:24112720}; Multi-pass membrane protein {ECO:0000269|PubMed:17727615, ECO:0000269|PubMed:17951461, ECO:0000269|PubMed:17971336, ECO:0000269|PubMed:17989085}. Note=Localized in a polar manner in the epidermis side facing the extracellular matrix (cuticle) and in the endosperm tissue of the developing seed (PubMed:20035035). Trafficking to the plasma membrane is independent of ABCG12 (PubMed:20870961). {ECO:0000269|PubMed:20035035, ECO:0000269|PubMed:20870961}.
Interaction partners:
- 3-ketoacyl-CoA synthase 6
- Non-specific lipid transfer protein GPI-anchored 1
- Non-specific lipid transfer protein GPI-anchored 2
- Very-long-chain aldehyde decarbonylase CER3
- Very-long-chain enoyl-CoA reductase
- Very-long-chain aldehyde decarbonylase CER1
- ABC transporter G family member 12
- Fatty acyl-CoA reductase 3
- Exosome complex component RRP45B
- Alkane hydroxylase MAH1
Sequence:
MEIEASRQQTTVPVSVGGGNFPVGGLSPLSEAIWREKAPTEFVGDVSARLTWQDLTVMVTMGDGETQNVLEGLTGYAEPGSLTALMGPSGSGKSTMLDALASRLAANAFLSGTVLLNGRKTKLSFGTAAYVTQDDNLIGTLTVRETIWYSARVRLPDKMLRSEKRALVERTIIEMGLQDCADTVIGNWHLRGISGGEKRRVSIALEILMRPRLLFLDEPTSGLDSASAFFVTQTLRALSRDGRTVIASIHQPSSEVFELFDRLYLLSGGKTVYFGQASDAYEFFAQAGFPCPALRNPSDHFLRCINSDFDKVRATLKGSMKLRFEASDDPLEKITTAEAIRLLVDYYHTSDYYYTAKAKVEEISQFKGTILDSGGSQASFLLQTYTLTKRSFINMSRDFGYYWLRLLIYILVTVCIGTIYLNVGTSYSAILARGSCASFVFGFVTFMSIGGFPSFVEDMKVFQRERLNGHYGVAAFVIANTLSATPFLIMITFISGTICYFMVGLHPGFTHYLFFVLCLYASVTVVESLMMAIASIVPNFLMGIIIGAGIQGIFMLVSGFFRLPNDIPKPFWRYPMSYISFHFWALQGQYQNDLRGLTFDSQGSAFKIPGEYVLENVFQIDLHRSKWINLSVILSMIIIYRIIFFIMIKTNEDVTPWVRGYIARRRMKQKNGTQNTTVAPDGLTQSPSLRNYIATRTDGARRW
Protein: Phosphoribosylpyrophosphate synthetase, putative (EC 2.7.6.1) (Q386K8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Transketolase
- Ribose-phosphate pyrophosphokinase, putative
- Ribokinase
- Ribose 5-phosphate isomerase, putative
- Orotidine 5'-phosphate decarboxylase
- NUDIX hydrolase, conserved
- ribose-phosphate diphosphokinase
- ribose-phosphate diphosphokinase
- inorganic diphosphatase
- inorganic diphosphatase
Sequence:
MGCAMHFARLYLSFSFRSPTYFQCDSCFCPFALYAFFAVTCVLSSPAYPIWFLPLLIINFVYRLDRCDNKKLGYVRQSPSRAISNMQGQADALTPKAQRVAAGETYFYREHRKPQVETSYRIRVISGTANYALSESVAKYLKVDLCRTEIKRFANGELNIKVVDDVRGDDCFILQPIAANEHTDINTAMMELLLLVHTLKLSSAKRITAIVPYFAYSRQDRKTEPRVPISASAVAQLLQCMGVDRVVTVDLHCGQIQGFFRNMPVDNLLMFPEFATYVMRQPWFDRERTVVVSPDAGGVERANVLADRIGASHIVTILKRRSGPGKVDSMQTVGNVEGYTCVIVDDIVDTAGTLCKACELLRDMGALRLVACATHGILTDPACERISQCDALTELVVSDSIAQNINSQKCNKLTVLTIAPLLVQAIYNLHFECSLSSLFRT
Protein: Transcription initiation factor TFIID subunit 13 (TBP-associated factor 13) (AtTAF13) (Q6NQH4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. May be involved in polycomb repressive complex 2 (PRC2) mediated repression.
Subcellular location: Nucleus {ECO:0000269|PubMed:23506837}. Cell membrane {ECO:0000269|PubMed:23506837}. Note=At the torpedo stage, localized both in the nucleus and at the plasma membrane.
Interaction partners:
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 12b
- Transcription initiation factor TFIID subunit 6b
- Transcription initiation factor TFIID subunit 4b
- Transcription initiation factor TFIID subunit 6
Sequence:
MSNTPAAAASSSSKSKAAGTSQPQEKRKTLFQKELQHMMYGFGDEQNPLPESVALVEDIVVEYVTDLTHKAQEIGSKRGRLLVDDFLYLIRKDLPKLNRCRELLAMQEELKQARKAFDVDEKELVD
Protein: GEO13501p1 (Uncharacterized protein, isoform B) (Uncharacterized protein, isoform C) (Q9VWX1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- AT04489p
- Uncharacterized protein, isoform D
- Uncharacterized protein, isoform A
Sequence:
MPNSSVISRVNAGLARCLSHHRRLCRGIAELDRLIHNDEFLKDPRTQWLLHQRRQTEEEQANADARISPLGRMGCEMGRLLGRSKINLSPQSRKNNLVVTRTFCQILQVENSTPRKQSGPMPAPTPLPSPERRQSLIFSASLSRPEP
Protein: Uncharacterized protein C1F8.04c (Q92342)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Putative purine nucleoside phosphorylase
- NASP-related protein sim3
- Inner kinetochore subunit sim4
Sequence:
MLYTHANIITVNPTRDILIDGAILVKDGSNTIDDIGKTDRLVSIYPNEKHKSLEGHIVMPGLISLHVHLAQSLLRSAADDLPLISWLCDTVWKMQGNFTQEDGYVASQLTIAEMLKSGTTTFVEALFAQRYGIEGAVKAVIESGIRGCIGKVVMDQPRYATQTGVSMHEGLIENSNSLNQAVESHSKFHGKGNGRVEIWFGARTPGGVSEELYRKMVKIARANNIGITMHCAEVKADREFFASKEHTPMTYCKDLGLLGPKTVLAHMVHLDTQDLEILEKHGNGTSVAHCPVSNSKLGSGIAPLKEMLEKSIIVGIGCDGCPCNNTMDLLQEMKMASLLPKALHGDPSIVPAEKIVEMATINGAKALGRDDLGSLEVGKKADFISLDLSNKLYAQPLRDLVSAVVYIATGADVATVVIDGKLIVEDHVLLTIDEPKLIDKAKKHGKKLQERAKVDVKGRWKEI
Protein: Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) (Q17348)
Organism: Caenorhabditis elegans
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P62318}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62318}.
Interaction partners:
- Probable small nuclear ribonucleoprotein-associated protein B
- Probable small nuclear ribonucleoprotein E
- Probable small nuclear ribonucleoprotein Sm D1
- Probable small nuclear ribonucleoprotein F
- Probable small nuclear ribonucleoprotein G
- U6 snRNA-associated Sm-like protein LSm7
- Probable small nuclear ribonucleoprotein Sm D2
- Probable U6 snRNA-associated Sm-like protein LSm4
- U1 small nuclear ribonucleoprotein C
- U6 snRNA-associated Sm-like protein LSm8
Sequence:
MTSVGVPIKILHEAEGHMVTLETVTGEVYRGKLSEAEDNMNCQLAETVVTFRDGRSHQLDNVFIRGNKIRFMILPDMLKNAPMFKNIGRAQKGAIGMGLGGLDQRGRGRGTAFRRPMGRGGPRGMSRPGGAPTFRG
Protein: Lectin (DlyL) (C0HK27)
Organism: Dioclea lasiophylla
Function: D-mannose-binding lectin that also binds alpha-methyl-D-mannoside with even higher affinity. Has hemagglutinating activity against rabbit erythrocytes. Shows toxicity against the brine shrimp A.nauplii. Induces reversible paw edema and hypernociceptivity in rats.
Interaction partners:
Sequence:
MGISKKSQLVPLLAFITMFLMVVSRVSSSIADANSLHFSFSQFSQNPKDLILQGDATTDSDGNLQLTRVSSDGSPQGSSVGRALFYAPVHIWEKSAVVASFDATFTFLIKSPDRDPADGITFFIANTDTSIPSGSGGRLLGLFPDANIIKNSTNLDFNAAYNADTIVAVELDSYPNTDIGDPSYPHIGIDIKSIRSKSTARWNMQTGKVGTAHISYNSVAKRLSAVVSYSGTSSTTVSYDVDLNNVLPEWVRVGLSATTGLYKETNTILSWSFTSKLKTNQLQDLRIASVV
Protein: Centrosomal protein 170 (H0Y4T4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
TRLGSLSARSDSEATISRSSASSRTAEAIIRSGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASALKTTRLQSAGSAMPTSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTLVDRVFDESLNFRKIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESKLRAESEVPIVKTSSM
Protein: Transcriptional regulator NRG1 (Zinc finger protein MSS1) (Q03125)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional repressor involved in regulation of glucose repression. Binds to UAS-1 in the STA1 promoter.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- General transcriptional corepressor TUP1
- pH-response transcription factor pacC/RIM101
- Probable transcriptional regulator NRG2
- General transcriptional corepressor CYC8
- Carbon catabolite-derepressing protein kinase
- Flocculation suppression protein
- Ty transcription activator TEC1
- Putative transcription factor PHD1
- Calpain-like protease 1
- Transcriptional regulatory protein UME6
Sequence:
MFYPYNYSNLNVSTMPALPGISAFDGMQDEENVEISPERKYQTLLPVLTNSHVVENELKHKLNKTAFDFRYQTKSENGSEKWEPKYLITPNLQTRSVSFDNSSVQYNSDSSEKSSLSQLTCNSSIIQQPENGIVSNDAYNKMANSRYSLKTRKQRTDPRNTLSDEEDLEQRRKYICKICARGFTTSGHLARHNRIHTGEKNHCCPYKGCTQRFSRHDNCLQHYRTHLKKGQ
Protein: Transcription factor 7-like 1-A (HMG box transcription factor 3-A) (TCF-3) (TCF-3-A) (zTcf-3) (Protein headless) (Q9YHE8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:11057671}.
Interaction partners:
- Catenin beta-1
- Catenin, beta 2.
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase
- Transducin-like enhancer protein 3-A
- SRY-box containing gene 17
- Mothers against decapentaplegic homolog.
- E1A-binding protein p300 b.
- E1A-binding protein p300 a.
- Mothers against decapentaplegic homolog.
Sequence:
MPQLNGGGGDDLGANDELISFKDEGEQEEKISENVSSERDLDEVKSSLVNESENNSSSSDSEQTDRRPRPRPDLESYEKQREYFAEALRRQQDGGFFKGPPYAGYPFLMIPDITNPYLSNGSLSPSTRTYLQMKWPLLDVPASAALKDSRSPTPGHLSNKVPVVQHPHHVHPLTPLITYSNEHFSPGTPPSHLSPEILDPKTGIPRTPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQHMYSIPPGGFRHPYPALAMNASMSSLVSSRFSPHMVPHPPHGLHQTGIPHPAIVSPAIKQEPNGESPSNSTHGKPSVPVKKEEEKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYGKRKKRKRDCKSDSPSESNFSPQPKKQCVPYLSSEKMCDSPTSSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPEGRAHHNHPHFPLPGKSSGSGSGSSMALHSLSRPIPFTSLPPSLLGPNSPFHQAALHSHHALLQTQPLSLVTKSVE
Protein: SET domain-containing protein (Q38CC2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPLTCLGPSKVVPGATGVFLTCALKKFTPVEIAPTVGATSPPYLCNLISAPRRTISLRRFLALRHQFSSGMCFNIATLRGWYLLAPSTHAPLSDPSGLRAWMQRHHHRYTHVCSTGNGSGSLGLRYEGEEQGVFTASGGDCNPADFEDEEDETVVEDKGDAMQSSAAASPGRSTSAGAVSPLCIQEEHLFEINDGILWEMPPNDDLASPTYWRRHRERMQVYEDTSVGVEQAELIGSDATGGSSHESVVAVEKEQYTGQLRLVRALTCKANVRLTVDDNTQLLVLMPVVDLKEGDELLLHYGREWWSHRLLSTLFMSVQDKEISDVRWVESLFAKPTDVHRPFPLLCRAFAGKRKRRLVGRERDAGREGRTSTECSNSEGTGNDAKVVLYNIATKKKATDSEALIFAVRRSCVDRNFFTSLVGGSERGAFNASRCDDEVPISRVRRVLLQSLRQGGGTVGEGPAKDSLDEGETQDDGSFCF
Protein: Mitochondrial carrier protein LEU5 (P38702)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the accumulation of coenzyme A in the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11158296, ECO:0000269|PubMed:16823961}; Multi-pass membrane protein {ECO:0000269|PubMed:11158296}.
Interaction partners:
- 2-isopropylmalate synthase
Sequence:
MTRDSPDSNDSYKHINKNTTQKTSFDRNSFDYIVRSGLAGGISGSCAKTLIAPLDRIKILFQTSNPHYTKYTGSLIGLVEAAKHIWINDGVRGFFQGHSATLLRIFPYAAVKFVAYEQIRNTLIPSKEFESHWRRLVSGSLAGLCSVFITYPLDLVRVRLAYETEHKRVKLGRIIKKIYKEPASATLIKNDYIPNWFCHWCNFYRGYVPTVLGMIPYAGVSFFAHDLLHDVLKSPFFAPYSVLELSEDDELERVQKKQRRPLRTWAELISGGLAGMASQTAAYPFEIIRRRLQVSALSPKTMYDHKFQSISEIAHIIFKERGVRGFFVGLSIGYIKVTPMVACSFFVYERMKWNFGI
Protein: Uncharacterized protein C21D10.08c (O74348)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSNVEQPFMQGIDDGWNLKNYLNIQSTSLCLDKLCNIYTQGQDENEDAKELQAIKIKIEWCKDTSVLLSSICVMLLDSIHDFLVQQGKITKESISKRDYSHEITIFNFKYAQQEMQNEKLYHFAKLLEPALESLKVTNNHITHATIVGQVSGSEHNLSTAIEQVDVIVNYFYDSSEKFLELGNKVQTLGKAKNKKHWLGVYQSFGKASVDQIQKQLECYNVRMMELNKTDENNESAICESQASSKEDERSDKTTSSSKKKSFTKLISNSRLNLWNKQ
Protein: Protein TRANSPORT INHIBITOR RESPONSE 1 (Weak ethylene-insensitive protein 1) (Q570C0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae.
Subcellular location: Nucleus {ECO:0000269|PubMed:15992545}.
Interaction partners:
- Auxin transporter protein 1
- Auxin-responsive protein IAA7
- SKP1-like protein 1A
- Auxin-responsive protein IAA14
- Cullin-1
- Auxin-responsive protein IAA17
- Auxin-responsive protein IAA3
- Auxin-responsive protein IAA9
- Auxin-responsive protein IAA12
- Auxin-responsive protein IAA28
Sequence:
MQKRIALSFPEEVLEHVFSFIQLDKDRNSVSLVCKSWYEIERWCRRKVFIGNCYAVSPATVIRRFPKVRSVELKGKPHFADFNLVPDGWGGYVYPWIEAMSSSYTWLEEIRLKRMVVTDDCLELIAKSFKNFKVLVLSSCEGFSTDGLAAIAATCRNLKELDLRESDVDDVSGHWLSHFPDTYTSLVSLNISCLASEVSFSALERLVTRCPNLKSLKLNRAVPLEKLATLLQRAPQLEELGTGGYTAEVRPDVYSGLSVALSGCKELRCLSGFWDAVPAYLPAVYSVCSRLTTLNLSYATVQSYDLVKLLCQCPKLQRLWVLDYIEDAGLEVLASTCKDLRELRVFPSEPFVMEPNVALTEQGLVSVSMGCPKLESVLYFCRQMTNAALITIARNRPNMTRFRLCIIEPKAPDYLTLEPLDIGFGAIVEHCKDLRRLSLSGLLTDKVFEYIGTYAKKMEMLSVAFAGDSDLGMHHVLSGCDSLRKLEIRDCPFGDKALLANASKLETMRSLWMSSCSVSFGACKLLGQKMPKLNVEVIDERGAPDSRPESCPVERVFIYRTVAGPRFDMPGFVWNMDQDSTMRFSRQIITTNGL
Protein: Copine-2 (Copine II) (Q96FN4)
Organism: Homo sapiens (Human)
Function: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P59108}. Nucleus {ECO:0000250|UniProtKB:P59108}. Cell membrane {ECO:0000250|UniProtKB:P59108}. Note=Translocates to the cell membrane and the nucleus in a calcium-dependent manner. Colocalizes with CD2 at the cell membrane. {ECO:0000250|UniProtKB:P59108}.
Interaction partners:
Sequence:
MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAGKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA
Protein: Caspase 9 (A0A0G2K3V0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEEADRQLLRRCRVRLVRELQVAELWDALLSRELFTRDMIEDIQRAGSGSRRDQARQLVIDLETRGRQALPRFISCLEDTGQGSLASFLQSSGQAAKQDPEAVTPLDHLVPVVLGPMGLKSKEQKVVKLDPSQPALGNLTPVVLGPEELWPTRLRPEVLTPETPRPVDIGSGRAHDVCEYQENAYTLDSDPCGHCLIINNVNFCPSSGLSTRIGSHVDCEKLQHRFCWLRFMVEVKNDLTAKV
Protein: Methyl-accepting chemotaxis protein CtpH (G3XDA3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for inorganic phosphate, which is required for taxis at high concentrations of phosphate. Recognizes inorganic phosphate directly. Can also bind to other components that have a pyrophosphate group, including ATP and ADP.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:27353565}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Chemotaxis protein CheA
- Chemotaxis protein CheA
- Chemotaxis protein methyltransferase 1
- Probable chemoreceptor glutamine deamidase CheD
- Probable purine-binding chemotaxis protein
- Chemotaxis protein CheW
- Protein-glutamate methylesterase/protein-glutamine glutaminase 1
- Chemotaxis protein methyltransferase 2
- Protein-glutamate methylesterase/protein-glutamine glutaminase 2
- Chemotaxis protein CheA
Sequence:
MPASPGHRDVLGCLVAACVPVQPGNPSRRSMLQQSLRAQILVLLGGSLAALLLIALACFGSLTGDVRAYRELLGGPVRAAQLIDEANLQFRGQVQEWKNVLLRGRQTEAQTKYWSQFEAQERAVQDILGRLGSVAEGELKDRVERLREEHRRLGTAYRQGRQRFLEAGADPIAGDQAVTGIDRATTAQMQTLRDELHQASDLHSSSISAEARRTMLLGSLVLIGASLAVALLSLWLVNRNLVRPVQRLIEHIAQLSHGDFGERIEIRRKDELGKLALAANTLRDFLVDIFDRLRRSTRDLDSASGSLNAIASLMAAGTREQFSRTDQVATAMQEMSATAQEVARYAGDAARAADEADDSAQRGEDVMEETIRSIGEMRKEIDHTVEVIRQLESDSGRIGKVLDVIRGIAEQTNLLALNAAIEAARAGDAGRGFAVVADEVRTLAQRTAESIAEIHQIIDTVQNGAVNAARAIESGQSRSEAGAEQVANAGAMLRQITASVESIRDMNRQIATAAEEQTAVAEEISRNLTEIASIASSNQEQVEQTEAASRDLHGLSAQLGDALQRLRA
Protein: Bile acid-CoA:amino acid N-acyltransferase (BACAT) (BAT) (EC 2.3.1.65) (Bile acid-CoA thioesterase) (Choloyl-CoA hydrolase) (EC 3.1.2.27) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2) (Q14032)
Organism: Homo sapiens (Human)
Function: Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine. More than 95% of the BAs are N-acyl amidates with glycine and taurine. Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism. This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption. May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12810727, ECO:0000269|PubMed:23415802, ECO:0000269|PubMed:8034703}. Peroxisome {ECO:0000250|UniProtKB:Q63276}.
Interaction partners:
- Long-chain fatty acid transport protein 5
- Sterol carrier protein 2
- Acyl-coenzyme A thioesterase 8
- Cysteine sulfinic acid decarboxylase
- Glutathione hydrolase 1 proenzyme
- Glutathione hydrolase 6
- Glutamate decarboxylase 1
- Glutamate decarboxylase 2
- Glutathione hydrolase 7
- Glutathione hydrolase 5 proenzyme
Sequence:
MIQLTATPVSALVDEPVHIRATGLIPFQMVSFQASLEDENGDMFYSQAHYRANEFGEVDLNHASSLGGDYMGVHPMGLFWSLKPEKLLTRLLKRDVMNRPFQVQVKLYDLELIVNNKVASAPKASLTLERWYVAPGVTRIKVREGRLRGALFLPPGEGLFPGVIDLFGGLGGLLEFRASLLASRGFASLALAYHNYEDLPRKPEVTDLEYFEEAANFLLRHPKVFGSGVGVVSVCQGVQIGLSMAIYLKQVTATVLINGTNFPFGIPQVYHGQIHQPLPHSAQLISTNALGLLELYRTFETTQVGASQYLFPIEEAQGQFLFIVGEGDKTINSKAHAEQAIGQLKRHGKNNWTLLSYPGAGHLIEPPYSPLCCASTTHDLRLHWGGEVIPHAAAQEHAWKEIQRFLRKHLIPDVTSQL
Protein: Bilin biosynthesis protein PecF (P29730)
Organism: Mastigocladus laminosus (Fischerella sp.)
Function: An enzyme involved in the biosynthesis of bilin.
Interaction partners:
Sequence:
MIAARFTNSKQLISQLNCALSPADALCAIAAISDSETTEVAVISALLQLLSRHHHHSSVATAAVEVLVKLAPASVEPLLAAFRSCSDQGFQAWIIQALAMIGDAKAFDLLAEVVGTEVANHCQGNVRRIAARGLGKIGSTVKDREVTDRAIEKLHWALVTPQDWGLRYAAVVSLQEIATPQAHAVLSAAVAGESDWVVRSRMKKALEQIPAC
Protein: Mitochondrial ornithine transporter 1 (Solute carrier family 25 member 15) (Q9WVD5)
Organism: Mus musculus (Mouse)
Function: Mitochondrial ornithine-citrulline antiporter. Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle. Lysine and arginine are also transported by the antiport mechanism (By similarity). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q12375}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:A0A0G2K309}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVVGLDQQAKLSDLQNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAASQNTVWSVVKEIFRKDGPLGFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGFGGICLWLAVYPVDCIKSRIQVLSMTGKQTGLVRTFLSIVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEAW