wanglab/gogpt-training-data huggingface dataset:
Protein: Nitric oxide synthase (EC 1.14.13.39) (Q6Y5E2)
Organism: Oryctolagus cuniculus (Rabbit)
Subcellular location: Membrane, caveola {ECO:0000256|ARBA:ARBA00004345}.
Interaction partners:
Sequence:
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPASPPPTPPAPDHSPKPSSNSPPLTRPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTQRRCLGSLVFPRKLQSRPTQGAPPPEQLLVQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRENELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRGPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQVPDEPPELFTLPPELVLEVSLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSGAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAARDIFSPKRSWKRQRYRLSTQTEGLQLLPGLIHVHRRKMFQATILSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPPTEPVAVEQLEKGSPGGPPPSWVRDPRLPPCSLRQALTFFLDITSPSSPRLLRLLSTLAEEPSEQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSIYPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQQRLHDIESKGLQPAPLTLVFGCRCSQLDHLYRDEVQDAQQRGVFGCVLTAFSREPDSPKTYVQDILRTELASEVHRVLCLERGHMYVCGDVTMATSVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDLPGSDTPGP
Protein: Malate:quinone oxidoreductase (EC 1.1.5.4) (MQO) (Malate dehydrogenase [quinone]) (P33940)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Citrate synthase
- Malate dehydrogenase
- NADP-dependent malic enzyme
- Phosphoenolpyruvate carboxylase
- Malate synthase A
- Fumarate hydratase class I, aerobic
- Fumarate hydratase class II
- Fumarate hydratase class I, anaerobic
- Phosphoenolpyruvate carboxykinase
- Malate synthase G
Sequence:
MKKVTAMLFSMAVGLNAVSMAAKAKASEEQETDVLLIGGGIMSATLGTYLRELEPEWSMTMVERLEGVAQESSNGWNNAGTGHSALMELNYTPQNADGSISIEKAVAINEAFQISRQFWAHQVERGVLRTPRSFINTVPHMSFVWGEDNVNFLRARYAALQQSSLFRGMRYSEDHAQIKEWAPLVMEGRDPQQKVAATRTEIGTDVNYGEITRQLIASLQKKSNFSLQLSSEVRALKRNDDNTWTVTVADLKNGTAQNIRAKFVFIGAGGAALKLLQESGIPEAKDYAGFPVGGQFLVSENPDVVNHHLAKVYGKASVGAPPMSVPHIDTRVLDGKRVVLFGPFATFSTKFLKNGSLWDLMSSTTTSNVMPMMHVGLDNFDLVKYLVSQVMLSEEDRFEALKEYYPQAKKEDWRLWQAGQRVQIIKRDAEKGGVLRLGTEVVSDQQGTIAALLGASPGASTAAPIMLNLLEKVFGDRVSSPQWQATLKAIVPSYGRKLNGDVAATERELQYTSEVLGLNYDKPQAADSTPKPQLKPQPVQKEVADIAL
Protein: Rhomboid-type serine protease 2 (EC 3.4.21.105) (Rhomboid protein 2) (Q12270)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable serine protease.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Rhomboid protein 1, mitochondrial
- Cell division control protein 48
- Uncharacterized protein YHR086W-A
- Cystine transporter
- Copper transport protein CTR2
Sequence:
MNWKSYVFPGGHPPAALTTGLVVFLTAIYLLSFIFALREDLSLAPESLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETHGTVYTGVFLNLSALFAGILYCLLGKLLYPEALVAGASGWCFTLFAYYSFKESQIRPRTRIFRTDYSIPTLYTPLVLLVAIAVVIPGSSFWGHFFGLCVGYAIGYKESWFNKITPPGWIITKIEKSLDGLIRLIPWGIKYYRDEDIDRTKDYEPLMSTETPLPLHNDNSGTVLGTA
Protein: Candida glabrata strain CBS138 chromosome M complete sequence (Q6FJN8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Candida glabrata strain CBS138 chromosome L complete sequence
- Candida glabrata strain CBS138 chromosome E complete sequence
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome J complete sequence
- Candida glabrata strain CBS138 chromosome K complete sequence
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome F complete sequence
- Candida glabrata strain CBS138 chromosome G complete sequence
- Candida glabrata strain CBS138 chromosome K complete sequence
- Actin-related protein 4
Sequence:
MDVPMPQRQLTKEEINRCYLKWQQLRNEHGKNAANVPEFIHLTKILHVAAKQQQEQKQKLQQQQQQQQQQQQVHVGTPQNDNKNNSEPWRVDNPNGSTFSHNKEQLETSTDQRPPNFTMNGTEGSASSASPATNPQVQFYKKENSNNGASQRDNFQSRTISDNSNSPATSPKSQVVTQNMPVRNNSQPNKSINSPHTINKPNDRQTQPAPLNPTQQRPVPQNSIFTPQQSELLRAQISALKSLVNNQPVPQEYQKVIQQSINNPPDFKRMLLSLSDFVKKKQLNQQSGSPASEIPEPQPQAQPPVQPPTEPQVQPQATPQAQSQPHAQSQQQDKNSTSDNAKIDTNTASANTSMTEEKPIIKTGTNTPNVTHEQIPPVGVQGTSSNTLREETHKTDTPSPRTIPGSVTHQIATPNLNKQENQNPETQNQYALKPPTERVPDPLVDGELKPAQQLPPVPIQKFVEKYPYVKNVVSIEDPDLMVDTFSIPTIPEEPVDYYSLFPNTANPKLVMEPGMLPAGVDIHTATDIYQTLIALNLDTSVNECISDMLDDSKDENTKEETLYDYFALQLLPLQKAVRGHVLQYEWYQNSLLTNAHPNFLSKIRNINFNDVLLTIELYRKREVIRQEEESKRYQQKLTRIRNSVVNTFNHKVHRRNKRIKLGHKLVATHANIEKEEQKRAERKAKERLQALKANDEEAYIKLLDQTKDTRITHLLKQTNAFLDSLTKAVKDQQKYTKDMLNQHLMEKKEESAEPVVYNDDQMLTMSMNDDDDDEENIDYYNVAHRIKEEVRQQPSILVGGTLKEYQIKGLQWMVSLFNNHLNGILADEMGLGKTIQTISLLTYLYEMKNIKGPFLIIVPLSTLPNWSSEFAKWAPKLRTISYKGSPNERKMKQAQIKSGEFDAVITTFEYIIKERAILSKVKWVHMIIDEGHRMKNAQSKLSLTLNTFYHSDYRLILTGTPLQNNLPELWALLNFVLPKIFNSAKSFDEWFNTPFANTGGQDKIELSEEETLLIIRRLHKVLRPFLLRRLKKDVEKELPDKVEKVIKCKMSALQHAMYQQMLKHKQLFIGDQKKNKLVGLRGFNNQLMQLKKICNHPFVFEEVEDHINPTRDTNMNIWRVAGKFELLERILPKLKASRHRVLIFFQMTQIMDIMEDFLRYIDIKYLRLDGHTRSDERGELLKLFNDPNSEYFCFILSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRIIRLITTNSVEEVILERAYKKLDIDGKVIQAGKFDNKSTAEEQEALLRSLLEAEEGRRRRREAGIEEEEELRDNEINEILARSEDDLALFSKLDTEREEADKAMHINSRLMTLDELPEIYHRNIDEELKKEESESAETYGRGTRERKQMIYSDNMSEEQWLKQFEVSDSEDKDPNKIMELKDDETDVNSNTIKTESNEAIRSSSISIPSSPTQTMNNTPETNDLDSDSGEYAKKRKAPSTRPRGRPKKIKTDDGENNPTESITGDVGDNTEDVVKRAGKTSIKSANTSSRGRGRGRGRGKPRGRAGMRGRGRPPKSKNGMVYVRMLPEDPVSEEERKGIAEQATKLYDFALNYVNSDERRLSDIFLVKPSKHLYPDYYLIIKYPIAFDTIKDAIDRLQYNSITEVMEDFHLMFANARVYNTEGSIIYEDAIELEDAMLQKYVEITNDTATLDFTEFDAKYGTKPLHIQEPETHSTNENTPQDSSKDII
Protein: Mechanosensitive ion channel protein 2, chloroplastic (Mechanosensitive channel of small conductance-like 2) (MscS-Like protein 2) (Q56X46)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer (By similarity). Controls plastid size, shape, and perhaps division during normal plant development by altering ion flux in response to changes in membrane tension. Acts as a component of the chloroplast division machinery.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:16401419}; Multi-pass membrane protein {ECO:0000269|PubMed:16401419}.
Interaction partners:
- Mechanosensitive ion channel protein 8
- Mechanosensitive ion channel protein 10
- Mechanosensitive ion channel protein 4
- Mechanosensitive ion channel protein 9
- Mechanosensitive ion channel protein 6
- Mechanosensitive ion channel protein 5
- Mechanosensitive ion channel protein 7
- Protein MID1-COMPLEMENTING ACTIVITY 1
- Protein MID1-COMPLEMENTING ACTIVITY 2
- Septum site-determining protein minD homolog, chloroplastic
Sequence:
MALYGTLQLSHSLGLCRNQRFCNPENSAMRRRLHISNGPLSLGVPLGQHGFSNILLSNYLRRPICSVPCRTTAFRCHSFSASGKAIEPAVKAVTVVLTKSHGLMQQFPFVYKLVPAVALLVFSLWGLVPFARQGRNILLNKNDNGWKKSGTYHVMTSYVQPLLLWLGALFICRALDPVVLPTEASKIVKDRLLNFVRSLSTVLAFAYCLSSLIQQTQKLFSETSNPSDTRNMGFQFAGKALYSAVWVAAVSLFMELLGFSTQKWLTAGGLGTVLITLAGREILTNFLSSVMIHATRPFVLNEWIQTKIEGYEVSGTVEHVGWWSPTIIRGEDREAIHIPNHKFTVNVVRNLTQKTHWRIKTHLAISHLDVNKINNIVADMRKVLAKNPMVEQQRLHRRVFLENVIPENQALSILISCFVKTSHHEEYLGVKEAILLDLLRVISHHRARLATPIRTIRKMYTETDVENTPFGESMYGGVTSRRPLMLIEPAYKINGEDKSKSQNRAAKPTAEQENKGSNPKSKETSSPDLKANVKVGESPVSDTNKVPEETVAKPVIKAVSKPPTPKDTETSGTEKPKAKRSGGTIKSTKTDETDSSTSSASRSTLEENIVLGVALEGSKRTLPIEEEIHSPPMETDAKELTGARRSGGNGPLVADKEQKDSQSQPNSGASTEP
Protein: DEAD/H-box helicase 11 (C9K0E8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKRQEEEERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEAL
Protein: Ribosome biogenesis regulatory protein homolog (Q9SH88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in ribosome biogenesis.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ribosome production factor 2 homolog
- Probable rRNA-processing protein EBP2 homolog
- AT5g04600/T32M21_200
- Ribosome assembly factor mrt4
- Nuclear/nucleolar GTPase 2
- Pescadillo homolog
- Large ribosomal subunit protein uL18y
- Probable ribosome biogenesis protein RLP24
- Pumilio homolog 24
- Ribosomal protein L1p/L10e family
Sequence:
MDTEMETEQIYQVDVGNLLAFNPNHRFPSAPSSRGELVKEILTEGTKLVQEIANKLFNFPSTETNDGPIVQLPPPTTKLPREKHIPRPKPPTKWEEFALKKGIQKRKKEKVVWDEQTNQFKRRHGYDRVNDDNDVPIIEAKESDEPGVDPFAKRLDDKKKRVGKQEKNRLQNLKAAEKAGALPSHVQLAATSLPISGTKAQPKKIGKDELGDVAGLAATSTASGGKFDKKLPGEKPPKKQGKHHKYLPVVSGRGDVNAEKEQTNNVLSKIFSKHSHEILNVGKAINMYNVKKEKKKSGRSDKLKPKKDITKKPANKAK
Protein: Aquaporin 8ab (Aquaporin-8) (S5R5I0)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Aquaporin
- Aquaporin
- Aquaporin-7-like
- Aquaporin
- Aquaporin
Sequence:
MGVEKMELDEGHSTLMSGTKKPPPVRPPNMFERIIQPCLAEVVGTMFFVFIGCVSVIENVESAGRVQPALVHGLAVAVMVACMDQISGSHFNPPFTIAIYLCGGMKLFMVIPYLISQLLGGVLGAAMSKMMTSKENYANATGAAFTILQSEDQLAGAIFGEIAMTCLVSMVVLLGAVNAKSKSPMVPFLVGCTVIINILAGGDVSGTCLNPARALGPAVMANYWTYHWVYWVGPIAGGLLAAGLVRLVLGDEKTRIIMK
Protein: Immunoglobulin superfamily member 2 (IgSF2) (Cell surface glycoprotein V7) (Glu-Trp-Ile EWI motif-containing protein 101) (EWI-101) (CD antigen CD101) (Q93033)
Organism: Homo sapiens (Human)
Function: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Leukocyte surface antigen CD53
Sequence:
MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCNVTGHQGPSEQHFQWSVYLPTNPTQEVQIISTKDAAFSYAVYTQRVRSGDVYVERVQGNSVLLHISKLQMKDAGEYECHTPNTDEKYYGSYSAKTNLIVIPDTLSATMSSQTLGKEEGEPLALTCEASKATAQHTHLSVTWYLTQDGGGSQATEIISLSKDFILVPGPLYTERFAASDVQLNKLGPTTFRLSIERLQSSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLRIQPAVKDFQVNITADSLFAEGKPLELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGVLGLKNDYKERASQGELQVSKLGPKAFSLKIFSLGPEDEGAYRCVVAEVMKTRTGSWQVLQRKQSPDSHVHLRKPAARSVVMSTKNKQQVVWEGETLAFLCKAGGAESPLSVSWWHIPRDQTQPEFVAGMGQDGIVQLGASYGVPSYHGNTRLEKMDWATFQLEITFTAITDSGTYECRVSEKSRNQARDLSWTQKISVTVKSLESSLQVSLMSRQPQVMLTNTFDLSCVVRAGYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGTIEWGNFLSRFQKKTKVSQSLFRSQLLVHDATEEETGVYQCEVEVYDRNSLYNNRPPRASAISHPLRIAVTLPESKLKVNSRSQVQELSINSNTDIECSILSRSNGNLQLAIIWYFSPVSTNASWLKILEMDQTNVIKTGDEFHTPQRKQKFHTEKVSQDLFQLHILNVEDSDRGKYHCAVEEWLLSTNGTWHKLGEKKSGLTELKLKPTGSKVRVSKVYWTENVTEHREVAIRCSLESVGSSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVEMEDAGMYWCRVAEWQLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLFICPFVLLLLLLISLLCLYWKARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEGN
Protein: AN1-type zinc finger protein 2A (Q8N6M9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MEFPDLGKHCSEKTCKQLDFLPVKCDACKQDFCKDHFPYAAHKCPFAFQKDVHVPVCPLCNTPIPVKKGQIPDVVVGDHIDRDCDSHPGKKKEKIFTYRCSKEGCKKKEMLQMVCAQCHGNFCIQHRHPLDHSCRHGSRPTIKAG
Protein: Interferon alpha-1/13 (IFN-alpha-1/13) (Interferon alpha-D) (LeIF D) (P01562)
Organism: Homo sapiens (Human)
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular location: Secreted.
Interaction partners:
- Interferon alpha/beta receptor 2
- Interferon alpha/beta receptor 1
- Interferon beta
- Tyrosine-protein kinase JAK1
- Non-receptor tyrosine-protein kinase TYK2
- Interferon regulatory factor 3
- Ubiquitin-like protein ISG15
- Interferon regulatory factor 7
- Interferon gamma receptor 1
- Signal transducer and activator of transcription 1-alpha/beta
Sequence:
MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFGFPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLEACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTNLQERLRRKE
Protein: Major sperm protein 38 (MSP) (P53020)
Organism: Caenorhabditis elegans
Function: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Subcellular location: Cell projection, pseudopodium. Cytoplasm, cytoskeleton.
Interaction partners:
- Major sperm protein 78
- Major sperm protein 33
- Major sperm protein 3
- Major sperm protein 49
- Nematode Specific Peptide family, group D
- Nematode Specific Peptide family, group D
Sequence:
MAQSVPPGDIQTQPGTKIVFNAPYDDKHTDHIKVINSSARRIGYGIKTTNMKRLGVDPPCGVFDPKEAVLLAVSCDAFAFGQEDTNNDRITVEWTNTPDGAAKQFRREWFQGDGMVRRKNLPIEYNP
Protein: Kelch domain-containing protein 2 (Endothelial differentiation inhibitory protein TNG) (Q4G5Y1)
Organism: Mus musculus (Mouse)
Function: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y2U9}.
Interaction partners:
- Elongin-B
- Cullin-2
- Amyloid protein-binding protein 2
- Kelch domain-containing protein 3
- Protein fem-1 homolog C
- Protein zyg-11 homolog B
- E3 ubiquitin-protein ligase RBX1
- Kelch domain-containing protein 10
- Protein zer-1 homolog
- Protein fem-1 homolog B
Sequence:
MADGNEDARAEDLPGPAFENYEAMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSADRGLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGVCPVGRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTYCISKNEWIQFNHPYVEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEVLIFSVQPKSLVRLSLEAVICFKEMLANSWSCLPKHLLHSVNQRFGSNNTSGS
Protein: ATP-dependent RNA helicase DOB1 (EC 3.6.4.13) (mRNA transport regulator MTR4) (P47047)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-dependent RNA helicase required for the 3'-end formation of 5.8S RNA. Cofactor for the exosome complex that unwinds secondary structure in pre-rRNA. Required for nucleocytoplasmic transport of mRNA. May serve as a chaperone which translocates or normalizes the structure of mRNAs in preparation for export. Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates.
Subcellular location: Nucleus.
Interaction partners:
- Protein AIR2
- Exosome complex component RRP42
- Ribosome biogenesis protein NOP53
- Exosome complex exonuclease RRP6
- Exosome complex component RRP4
- Poly
- Exosome complex component RRP46
- Exosome complex component RRP40
- Poly
- Protein AIR1
Sequence:
MDSTDLFDVFEETPVELPTDSNGEKNADTNVGDTPDHTQDKKHGLEEEKEEHEENNSENKKIKSNKSKTEDKNKKVVVPVLADSFEQEASREVDASKGLTNSETLQVEQDGKVRLSHQVRHQVALPPNYDYTPIAEHKRVNEARTYPFTLDPFQDTAISCIDRGESVLVSAHTSAGKTVVAEYAIAQSLKNKQRVIYTSPIKALSNQKYRELLAEFGDVGLMTGDITINPDAGCLVMTTEILRSMLYRGSEVMREVAWVIFDEVHYMRDKERGVVWEETIILLPDKVRYVFLSATIPNAMEFAEWICKIHSQPCHIVYTNFRPTPLQHYLFPAHGDGIYLVVDEKSTFREENFQKAMASISNQIGDDPNSTDSRGKKGQTYKGGSAKGDAKGDIYKIVKMIWKKKYNPVIVFSFSKRDCEELALKMSKLDFNSDDEKEALTKIFNNAIALLPETDRELPQIKHILPLLRRGIGIHHSGLLPILKEVIEILFQEGFLKVLFATETFSIGLNMPAKTVVFTSVRKWDGQQFRWVSGGEYIQMSGRAGRRGLDDRGIVIMMIDEKMEPQVAKGMVKGQADRLDSAFHLGYNMILNLMRVEGISPEFMLEHSFFQFQNVISVPVMEKKLAELKKDFDGIEVEDEENVKEYHEIEQAIKGYREDVRQVVTHPANALSFLQPGRLVEISVNGKDNYGWGAVVDFAKRINKRNPSAVYTDHESYIVNVVVNTMYIDSPVNLLKPFNPTLPEGIRPAEEGEKSICAVIPITLDSIKSIGNLRLYMPKDIRASGQKETVGKSLREVNRRFPDGIPVLDPVKNMKIEDEDFLKLMKKIDVLNTKLSSNPLTNSMRLEELYGKYSRKHDLHEDMKQLKRKISESQAVIQLDDLRRRKRVLRRLGFCTPNDIIELKGRVACEISSGDELLLTELIFNGNFNELKPEQAAALLSCFAFQERCKEAPRLKPELAEPLKAMREIAAKIAKIMKDSKIEVVEKDYVESFRHELMEVVYEWCRGATFTQICKMTDVYEGSLIRMFKRLEELVKELVDVANTIGNSSLKEKMEAVLKLIHRDIVSAGSLYL
Protein: Uncharacterized protein C22G7.07c (Q09800)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable zinc transporter zip2
- DUF1769 family protein duc1
- Putative D-3-phosphoglycerate dehydrogenase
Sequence:
MPCILYMDDTSCLIDLPTSLQFNKHILPTRTKPVVKPYLLPEKSTSDYENSGKGTVGQVLQSLQRVRRALQLRSLDDNQSTDKSHHVQFQDIVYRSNTSASEIHFQAENAPLVQWYSDIFKVLVKAPVIQFEDQCLQWLKMLNTIPPSYSFITIKSKDTVELGLEEIYQQCVQNDGASAIKLKLKGSKVITESSETNCRDSIYYIPARSSFIMGDVEKTAQILLEAIDGHLEKPKCIIIDPPWPNKSVARSSVYKVNRNLGYLKALPIQESLSKTGVVAVWCTNKEKYVNFVKKVLFKKWNLTLVSTWTWLKITAFGEPLFDVYSNMRKPWEQLLIGVTSEYTSVYSDKIPPTFTIIGIPDYHSRKPSLKPFISRWFNCSANESLPVLEIFGRSLTPNWITWGREPLLFMHELYWSSDN
Protein: Casein kinase II subunit beta (CK II beta) (P28548)
Organism: Caenorhabditis elegans
Function: Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2.
Subcellular location: Cell projection, axon {ECO:0000269|PubMed:16481400}. Cell projection, cilium {ECO:0000269|PubMed:16481400}. Cell projection, dendrite {ECO:0000269|PubMed:16481400}. Perikaryon {ECO:0000269|PubMed:16481400}. Note=Enriched in cilia in male sensory neurons.
Interaction partners:
- Casein kinase II subunit alpha
- FACT complex subunit spt-16
- Ribosomal RNA-processing protein 7 homolog
- Nucleolar protein 6
- FACT complex subunit SSRP1-A
- WD_REPEATS_REGION domain-containing protein
- DiSHevelled related
- DiSHevelled related
- FUN14 domain-containing protein fndc-1
- UMP-CMP kinase 2
Sequence:
MSSSEEVSWITWFCGLRGNEFFCEVDEEYIQDRFNLTGLNEQVPKYRQALDMILDLEPDDIEDNATNTDLVEQAAEMLYGLIHARYILTNRGISQMVEKWRDHDFGVCPRVYCENQPMLPIGLSDVPGEAMVKLYCPRCNDVFVPRSSRHQHTDGSYFGTGFPHMLFFVHPDLRPRRPVTQFVPKLYGFKIHPVAYGGQEGNSGGNTANNVAAAQNNTTPAGQQSGGQFNNYGL
Protein: Chalcone 4'-O-glucosyltransferase (4'CGT) (Am4'CGT) (EC 2.4.1.286) (Q33DV3)
Organism: Antirrhinum majus (Garden snapdragon)
Function: Glycosyltransferase involved in the biosynthesis of aurones, plant flavonoids that provide yellow coloration to flowers.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16832053}.
Interaction partners:
Sequence:
MGEEYKKTHTIVFHTSEEHLNSSIALAKFITKHHSSISITIISTAPAESSEVAKIINNPSITYRGLTAVALPENLTSNINKNPVELFFEIPRLQNANLREALLDISRKSDIKALIIDFFCNAAFEVSTSMNIPTYFDVSGGAFLLCTFLHHPTLHQTVRGDIADLNDSVEMPGFPLIHSSDLPMSLFYRKTNVYKHFLDTSLNMRKSSGILVNTFVALEFRAKEALSNGLYGPTPPLYLLSHTIAEPHDTKVLVNQHECLSWLDLQPSKSVIFLCFGRRGAFSAQQLKEIAIGLEKSGCRFLWLARISPEMDLNALLPEGFLSRTKGVGFVTNTWVPQKEVLSHDAVGGFVTHCGWSSVLEALSFGVPMIGWPLYAEQRINRVFMVEEIKVALPLDEEDGFVTAMELEKRVRELMESVKGKEVKRRVAELKISTKAAVSKGGSSLASLEKFINSVTR
Protein: Growth hormone receptor (Somatotropin receptor) (A0A087X0H5)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MNWGPTGMDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP
Protein: T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (B0YIY5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN
Protein: Protein S100 (S100 calcium-binding protein) (Q5XJJ5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- PDZ domain-containing protein.
- AHNAK nucleoprotein
- Annexin.
- Annexin
- Annexin
- Si:ch211-125o16.4.
- Protein S100
- Helicase-like transcription factor.
- Annexin
- S100 calcium-binding protein U
Sequence:
MPSELETAMESLIMVFHRYAGKEGRSGTLTRRELRILMENELSGFLKSQKDPTFVDRIMKDLDANGDGEVDFEEFVSLVLGLSIACEACYRVDLRKSQSWNL
Protein: Uncharacterized protein, isoform A (Q86BH9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIEVDDQITKPLNLANSAVLRAVEEEEQQAKCGYKRVAWPPASEERIIREFTPQPQTQSPAPGAGGYYPQAHAPTAAAAAPPQGPIYNNVQPRTTQTPQNAYPSAPQTTSTAYPTNQYPDSYSHQEQQQQQQQQQPVQYTQAQFGRQRSREPVQVSAPSPAPATDPSGYPYQANYQSNYPQEPLQAVNNVGGGWKHIGAPQPKSRSEFTAGNGAYPPFQGSYQQQQQQPQQQYGAPSYDGQQPGAQWQQQQQQQQVPQQQYQPQSQAQAPYQPPQWNQPQQQQQQPSYQASPYQQQQQQQPSYYPQQNGGSTYAQPPYNSYSQPQLPYSQDQTDLQQQQQQQQQQYPGAYAGQDSYRGASPGIITLRKEAPVSQKPAPVYTSQPAAVSYQGGSKLRGDLKWPPPEYKEAAARENEERRQLALGPVCRPRRVNRDYTPFFAKHQLNNGYPSYKVPPGTQHIFG