wanglab/gogpt-training-data huggingface dataset:
Protein: Nphp4 protein (Q32Q04)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGDRQSFQTTCRKKGKESGTSGEWEPEKQRLREDSDVAPRVRQARHSVRAQHSRDLQVIDAYRERTKAENIASVLSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEIDSPELSIILDSQEWRYFKEATGLLTPLEEDMFHLRGSLAPQLYLRPRETAHIPFKFQNFSVGPPAPTQAPAEVISEKDAESGPHWKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGLGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQMTRLSLVLRGTQTVRKVRAFTSHPQELKTDPAGVFVLPPHGVQDLHVGVRPRRAGSRFIHLNLVDVDYHQLVASWLVCLSCRQPLISKAFEITMAAGEGKGANKRITYTNPYPSRRTYRLHSDRPDLLHFKEDSFQVAGGETYTIGLRFLPSGSAGQEEILIYINDQDDKNEETFCVKVLYQ
Protein: E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (RING finger protein 34) (RING finger protein MOMO) (RING-type E3 ubiquitin transferase RNF34) (Q6AYH3)
Organism: Rattus norvegicus (Rat)
Function: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q969K3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q969K3}. Endomembrane system {ECO:0000269|PubMed:12859687}; Peripheral membrane protein {ECO:0000305}. Nucleus {ECO:0000250|UniProtKB:Q969K3}. Nucleus speckle {ECO:0000250|UniProtKB:Q969K3}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q969K3}.
Interaction partners:
Sequence:
MKAGATSMWASCCGLLNEVMGTGAVRGQQAGFPGSTGPFRFTPSSDFPTYPPAATEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSLCSVSQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQYLLLRNVPTDTCREKEDLVDLVLCHRGLGSGDGLDSRSLSSSRSQTSSFFTQSYFSNYTPPSATVSSFQGELMDREGTFRSEVLTQVQSELASANTDDEDGEEDDDDDDDDDDEDDDEQEENLEEQNPGLSKKKARASLSDLSSLEEVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERMQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS
Protein: Uncharacterized protein C12G12.11c (Q09874)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14655046}.
Interaction partners:
- Polyubiquitin
Sequence:
MDNVQEHDPDTQEHNNETQNHKQEDHSNSYQTRTIPFIEPLSREYQKRIILCQTVNGPCPIIALSNALILKSNVDRPFELPKKRYITPDELTEYLVEFAKAYGLCKNQQSLQDKLTSMHFGQQLNPCLYDIEKFEYGHEIFCTFGVRLVHGWILSDDMGLSDEDLSYLRKLEYYEKVADTFAERRSLLEMQEPLTEQQQDFLNNSTCVDKVMENRYTMQFLTNAGLKKILELVGPGEIVVVFRSSHFSTMYSNPDSFAQFTLVTDSGYARTGEDVVWETFDSQTVETGNGELCAANFIPAVYVLNQRKEEKKKRAKDDEQYAKRLAKEEEERGKKETPKKASNTPRRNKSNTQKSRKQSENCLIS
Protein: Protection of telomeres protein 1 (F1D6H6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPVEKVNNSSDLDTKVPSCLQLTSIGQLTLTSDPSHRCVKARVLRKGPVISCAQRDGLEMLRAEIREEDPLQSTTEHTSINVIFFDTLAKDFSQSVKQGDIVLLANFTISKSPTFLRDKLHPCQLEMDNKDACVYVCPSAIPGPSSSEAKYVYVPLNKLKSKTLVNVYGVVTFFKQPFPSKGSDYCTTLKITDQSDVKVICTIFCKKLEDHPLIFRVGDIIRLHRFKAEAFRDSITLINTFGWSTVTFNGIIDSPIVPRTSSKSFFYGEADKRRVQELRQWAANQSLCSDLNTSLSSVQPHMYFDFTCQLLAKAVMHSGCILLKVWDGTRCQLPLLQVAVPPDELKGECTLAKDKMNLTANVLVYDNHLEVARDLKPGAFLRFYNLRALLQKVPGQLPDQPEHLGFHLHGGTVYGRGLRSLPAETPDLLSLKSVLEKHVDLDEHEEVNDGTLLEIWYTPPESIVLPNDENPGAEENAGPAYTVQTCEHNTQRITLAQVKRSTPPLSCHVRARVKKYLPQQLYQCLKLFCSKCKTMKDVPDDSAVANIFLESARDNQPCDEQWAATSSANSREPGRTISMHVSKDMVGKSSHMQLIFIEGMTLDEISVLSRDHKNLVPVRSENSKMTRMDLTAPFLFSGKKRYYGCKQCSRNTFENPVFTGVETWDEQAVAAVLGVQMMQYRFLIQFELDDVTDTIEALLWEDAERFFHISAVDASGCQDLQDRIQTIMDTIQPPESSLEERPWMDFCLSVYTVKDNDRNKVCYQITNTEIVKQ
Protein: Uncharacterized protein AN2204 (Q5BB76)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Involved in osmoadaptation.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSHLNGSEPSRAQRETEGRWEEKNVLCDQIKEIIAALNDIRTQLAEQNKYLDVLTETYVRKPAPTHLVFAQELETGGWEEGSDWGEYADFAQGEILPAPGLEYEGSCEQNYEGKYKGDYEENYEENYEENYGEENYEEVKGRYREEEKESPKVDSFHVNETAASRNQREPILAESKGDMQKQKCYSLESTGPSFYLPLGLVISAHVSQASFTTVFIILSLAAYIFATFTLWFLREEDWVKRIIGSWRLAKANASASANSNANAITDSIQADQDRGSRIPDLLRRRQVLETS
Protein: Claudin (Q96FX9)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, tight junction {ECO:0000256|RuleBase:RU060637}. Cell membrane {ECO:0000256|RuleBase:RU060637}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU060637}.
Interaction partners:
Sequence:
MSMAVETFGFFMATVGLLMLGVTLPNSYWRVSTVHGNVITTNTIFENLWFSCATDSLGVYNCWEFPSMLALSGSTDSPASLSGGTGLLVRLMSIKGPCEGRRLASCRLSVRCKEAVCVQGIFRPAGHS
Protein: Uncharacterized protein C7D4.13c (O14268)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSLFIGTHNIKNSAIQLLKTKLKNEFLKGVKCITKYPENAHSIFKVQEYTGYKGVTFIVSTKWNLTVDSIHKLIPEIKSSPSACLLLVNQPYPVIEKITDILTKHGITNANLLEFSKSSLLHPFKRNRHLLSFVPYPMTAETLGDISWSFSRRENMKFEKDQQYILSKFKSPRNLLIPYPSFLIQKFLDMAILPPMAALRILFYQYSKASTMSLTDDFYNKYVLENLNIINNLQIFLHLDLEPLHIKSLAKARKRFYETDLKTTFLNAFSRDELLMLVNYFIFRGTELKLSVSMNLAFRDILLSSAYLNKTK
Protein: Alpha-2-HS-glycoprotein (Countertrypin) (Fetuin-A) (P29699)
Organism: Mus musculus (Mouse)
Function: Probably involved in differentiation.
Subcellular location: Secreted.
Interaction partners:
- Albumin
- Toll-like receptor 4
- Prothrombin
- Fibrinogen alpha chain
- Matrix Gla protein
- Plasminogen
- Vitamin D-binding protein
- Apolipoprotein A-II
- Fibrinogen gamma chain
- Protein AMBP
Sequence:
MKSLVLLLCFAQLWGCQSAPQGTGLGFRELACDDPEAEQVALLAVDYLNNHLLQGFKQVLNQIDKVKVWSRRPFGVVYEMEVDTLETTCHALDPTPLANCSVRQLTEHAVEGDCDFHILKQDGQFRVMHTQCHSTPDSAEDVRKLCPRCPLLTPFNDTNVVHTVNTALAAFNTQNNGTYFKLVEISRAQNVPLPVSTLVEFVIAATDCTAKEVTDPAKCNLLAEKQHGFCKANLMHNLGGEEVSVACKLFQTQPQPANANAVGPVPTANAALPADPPASVVVGPVVVPRGLSDHRTYHDLRHAFSPVASVESASGETLHSPKVGQPGAAGPVSPMCPGRIRHFKI
Protein: E3 ubiquitin-protein ligase ATL15 (EC 2.3.2.27) (RING-H2 finger protein ATL15) (RING-type E3 ubiquitin transferase ATL15) (Q9SK92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8, UBC10, UBC11, UBC28 and UBC29 in vitro.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Tetratricopeptide repeat
- Eukaryotic aspartyl protease family protein
- Protein DUF642 L-GALACTONO-1,4-LACTONE-RESPONSIVE GENE 1
- Leucine-rich repeat
- Protein DETOXIFICATION 25
- At1g73120
- C3HC4-type RING finger protein
- C3HC4-type RING finger protein
Sequence:
MVVMSRVSFYSSFLLLLLEVVVASSEFDDEGRTSFSPTTAIIMIVLVSVFFALGCISVYMRRCLQHALGMDSGGGPGNWLNVRQTTEPGLDASVIETFPTFPYSTVKTLRIGKEALECPVCLNEFEDDETLRLIPQCCHVFHPGCIDAWLRSQTTCPLCRANLVPVPGESVSSEIPGLARETGQNSLRTPIDDNRKRVLTSPDERLIDSVAWTGNQSMPRKSMSTGWKLAELYSPASSPGQPEENLDRYTLRLPQEIHDQLVNSSLGKQGSKGQLALPQERSSVRGFRTGSLGTEKNYFYFERFDQDGRLDRRPFSITPPYHTRSIQSPDEIINASGNYQDRAGAPKGLLLAIRSPFDRLFTGKKNAGERSYLQSGDASPV
Protein: PHD finger protein MALE MEIOCYTE DEATH 1 (Q7X6Y7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor required for chromosome organization and progression during male meiosis (e.g. microsporogenesis). Necessary for fertility and meiotic progressive compaction of prophase I chromosomes to metaphase I bivalents. Together with JMJ16, promotes gene expression in male meiocytes in an H3K9me3-dependent manner, and contributes to meiotic chromosome condensation by triggering some condensin promoters (e.g. CAP-D3 and CAP-H).
Subcellular location: Nucleus {ECO:0000269|PubMed:12782723, ECO:0000269|PubMed:32572214}.
Interaction partners:
- Cysteine/Histidine-rich C1 domain family protein
- Chromatin remodeling protein SHL
- Sister chromatid cohesion protein SCC2
- PHD finger protein ALFIN-LIKE 5
- Alpha/beta-Hydrolases superfamily protein
- Chromatin remodeling protein EBS
- Protein OBERON 2
- Protein OBERON 1
- PHD finger protein ALFIN-LIKE 7
- Protein ENHANCED DOWNY MILDEW 2
Sequence:
MPVPIIETCRKRKRKPKVYNLQRFGEDGFPIQRNGAFRDQIRVFLRDCAEIEDYDIRGMTVWCTLLSHETKSSLIPLYIVEENVKHSSEPYCDHCRCTGWSNHFVSKRKYHFIIPIDTEWSLPLEDDAFDSQSHVLHGLIHCNGFGHLVCVNGMESGSKYLCGREIVDFWDRLCNSLGARMITVEDLAKKRSVELRLLYGVAYGHSWFGRWGYKFCCGSFGVTKNEYENAIEALGSLEIDQIEFDFGELRQSKEINQVFRYYREMSEGHLKTFRDLLRFMLIIKSHASPQKLLPVTPPLLTDSPHQKRSSRLLLKKSDVADNDKSPKYRNYSTVAANLGSRWPVRRLIFAAEVIVESLKEMKALKQNGMTRQDVRDSARLHIGDTGLLDYVLKSMNNVVVGDVLVRRYVDPITRILHYTIQDLDDAVKAKEPKKKEAVVLEEITPLRILTPLKPGADVYGDLLLLYTNVLLNYPESELVRSATQAILDSKHFIKEWPIWDNNDTVLQFLCRINPSLVDVRSEQTTELPPGELVTVPLQATVYDLKQAIEETFRDTYCILSNFVVTEIDEVEEDMSLIGSCSALTVRGHGIDLESKLKCQGGCDTWMVKCICRARDDDGERMISCDVCEVWQHTRCCGIDDSDTLPPLFVCSNCCEEFAEQQRKVLQPKYEFPSSENVFLLESADDFFGDQRCLGMIFPEENYLL
Protein: U-box domain-containing protein 43 (EC 2.3.2.27) (Plant U-box protein 43) (RING-type E3 ubiquitin transferase PUB43) (Q9SFX2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as an E3 ubiquitin ligase.
Interaction partners:
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- SCY1-like protein 2 A
- SCY1-like protein 2 B
- ARM repeat superfamily protein
- ARM repeat superfamily protein
- ARM repeat superfamily protein
Sequence:
MAGSGSWDGSQSDNSSQFEPGIDNIYEAFICPLTKQVMHNPVTLENGQTFEREAIEKWFQECRENGQPLSCPITSKELSITDLSPSIALRNTIEEWRARNDALKLDIARQSLYLGNAETNILLALKNVREICRNIRKIRQRVCNPQLVRLITDMLKSSSHEVRCKALQTLQVVVEGDEESKAIVAEGDTVRTIVKFLSQEPSKGREAAVSVLFELSKSEALCEKIGSIHGAIILLVGLTSSKSENVSTVEKADKTLTNLERSEENVRQMAINGRLQPLLAKLLEGSPETKVSMAFYLGVLALNNDVKVIVAQTVGSSLIDLMRTRDMSQREAALGALNNISSFEGSAKLLINTGILPPLIKDLFYVGPNQLPIRLKEVSATILANIVNIGYDFDKVPVGPHHQTLVSEEIVENLLQLTSNTGPEIQGKLLAVLVGLTSCPNSVINVVSAIRNSAAIISLVQFVEIHENDDLRLASIKLLHNISPHMSEELANALRSTVGQLGSLVSIISENTPTITEEQAAAAGLLAELPERDLVLTMRLLREGAFEKIISKIVGIRQGEIRGIRFERTFLEGLVSILARITFALTKETDATLFCCEKNLPSLFLDLLQSNSQDNIQRASATALENLSLESKNLTKIPELPPPTYCVSIFSCLSKPPVVLGICKIHQGICSVRESFCLVEGQAVDKLVDLLDHENDKVVGPALAALSTLLEDGLDVVQGVRLIDEADGITPILNVLLENRTENLRIRAVWMVERILRIEEIAREVGEEQNVTAALVDAFQNADFRTRQIAEKALRHIDKIPNFSGIFTNIG
Protein: Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (Dihydroorotate oxidase) (EC 1.3.5.2) (P32748)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uridine 5'-monophosphate synthase
- Multifunctional protein r
- FI21247p1
- FAD-binding FR-type domain-containing protein
- NADH-cytochrome b5 reductase
- Uncharacterized protein, isoform B
- FI17329p1
- LD30822p
- dihydropyrimidinase
- allantoinase
Sequence:
MDQDHLKNAKNATRRVGRLRSLGIVTVGGAALVAGITAYKNQDQLFRTFVMPAVRLLPAEASHQLAVLACKYRLCPVSQYHDDQNLHTSFFGRMLSNPIGIAAGFDKNAEAVDGLQDLGFGFIEVGTVTPAAQEGNPKPRVFRLTEDKAIINRYGFNSDGHQAVLQRLRLLRKKENFNGVVGVNLGRNKTTMSPIADYVQGVRVFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNVPILLKLSPDLSLDDMKDIVWVIKRKKSRVDGLIVSNTTVSRENIEKNKLAEETGGLSGPPLKARSTEMIAQMYQLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQIYTALVYEGPALVEDIKAELSALITRLGHTNVADVVGTNSKFYLPK
Protein: Fructan 1-exohydrolase w1 (EC 3.2.1.153) (Q84PN8)
Organism: Triticum aestivum (Wheat)
Function: Hydrolyzes inulin-type beta-(2,1)-fructans and beta-(2,1)-linkages in branched fructans. Has low activity against beta-(2,6)-linked fructans. May play a role as a beta-(2,1)-trimmer during graminan biosynthesis.
Interaction partners:
- fructokinase
- fructokinase
- fructokinase
- galactinol--sucrose galactosyltransferase
- galactinol--sucrose galactosyltransferase
Sequence:
MAQAWAFLLPVLVFGSYVTSLFFPSYISGPLCGGDGGGRSLFLCAQAPKDQDPSPAVSTMYKTAFHFQPAKNWMNDPSGPMYFNGFYHEFYQYNLNGPIFGDIVWGHSVSTDLVNWIGLEPALVRDTPSDIDGCWTGSVTILPGGKPVIIYTGGDKDQHQAQNIAFPKNRSDPYLREWIKAANNPVLRPDEPGMNSIEFRDPTTGWIGPDGLWRMAVGGELNGYSAALLYKSEDFLNWTKVDHPLYSHNGSNMWECPDFFAVLPGNNAGLDLSAAIPQGAKHALKMSVDSVDKYMIGVYDLQRDAFVPDNVVDDRRLWLRIDYGTFYASKSFFDSNKNRRIIWGWSRETDSPSDDLEKGWAGLHTIPRTIWLADNGKQLLQWPVEEIESLRTNEISHQGIELNKGDLFEIKEVDAFQADVEIGFELASIDDADPFDPSWLLDPEKHCGEAGASVPGGIGPFGLVILASDNMDEHTEVYFRVYKSQEKYMVLMCSDLRRSSLRPDLEKPAYGGFFEFDLEKERKISLRTLIDRSAVESFGGGGRVCITSRVYPAVLADVGRAHIYAFNNGSATVRVPQLSAWTMRKAQVNVEKGWSAI
Protein: Epithelial cell adhesion molecule precursor (Zgc:110304) (Q568H0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MKVLVALFVVALVDVVTSQCACKTMKWANCDDSCSCSLTLTESSTQTLNCSKLVPKCFLMQAEMYRACNHQDTRSGGKPVETAFVDNDGIYDPVCESDGKFKAVQCNNTEVCWCVNSAGVRRSDKKDKNIKCEPAETYWVRVEMKHKSVDVPIDATKLRTGIENVLQQRYGLDKKLVSEVQYDKDGRLIVVDVKKDKDDRTTDLSLMTYYMEKDIKVLPLFWNGQPFEVDVPGTKVSMENVLIYYVDDRAPTFTMQKLTGGIIAVIVVVSLIVIGGFLVLFFLARRQKAQYSKAQAREMETIS
Protein: Flavin reductase (NADPH) (EC 1.5.1.30) (Flavin dependent oxidoreductase) (Flavin:NAD(P)H reductase) (Q8KI76)
Organism: Lentzea aerocolonigenes (Lechevalieria aerocolonigenes) (Saccharothrix aerocolonigenes)
Function: Catalyzes the NADH-dependent reduction of FAD to provide FADH2 for the halogenase RebH.
Interaction partners:
Sequence:
MTIEFDRPGAHVTAADHRALMSLFPTGVAVITAIDEAGTPHGMTCTSLTSVTLDPPTLLVCLNRASGTLHAVRGGRFGVNLLHARGRRAAEVFSTAVQDRFGEVRWEHSDVTGMPWLAEDAHAFAGCVVRKSTVVGDHEIVLGEVHEVVREHDLPLLYGMREFAVWTPEG
Protein: Mitosis initiation protein fs(1)Ya (P25028)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cell cycle-dependent nuclear envelope component required for embryonic mitosis.
Subcellular location: Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm. Note=In the nuclear envelope during interphase to metaphase. And in the nucleoplasm and cytoplasm during anaphase and telophase.
Interaction partners:
- non-specific serine/threonine protein kinase
- Uncharacterized protein, isoform A
- Tubulin alpha-4 chain
- Vitellogenin receptor Yl
- pH-sensitive chloride channel 2
- Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
- Deubiquitinase otu
- DNA replication inhibitor plutonium
- CG5272 protein
- IP11267p
Sequence:
MSFSNVLIMRQPDEGKCHICKRVFCCGKCRQKHQFKAHAIAVREPLGLRSAGGGIIEHRHQMESGATTIYVFCPICERRPLLLREEMHGELLAHIETCHLPLRCRKCQRNYTRVDDLREFSKCVDQQQSCTDVTGATETSKATLKKAANSTAISTQTSPSVTPISLINMRWKAKSRVTHEEFISDSVSSIRNLSSFSNSSIRRSIGQLGVNPSETMEKGKVIRSTSTPLHVESVFAKPKEPITFNASTGGHVSSIYHEEPSPTPESNPVQQQQQQQQPLQQRAWKMGARNKMSAATPLRQVMSKSIQKAFVEHGGMMVHQPPSAVVQRRVRLDLSEHSSHEAAGSSALDLRLSPAMRRTQSESSASEVNSGSSSSYSTSRNADLCKRQFLLSAQKLTTESIIITRTNSSSQKTSSTVYNSCESVEIIRSTSESAEVCHVPAITPIRVTGAGINKKQIKFETPPKSSQQMRSNGEGDETKDQFFTPEPGTPEIPERRHRQAIVPRQLSGEFSPKKDKPKEKGLAVMALISPPLQQPRVRPPLRECRQQRVYSGVQDVGEPEVVDAEEEDEVFRPTNASTCNDKKLEAPNSGRLWSLMSSMMRLPASLRGEREKDRDRDRDSDKENAGSGSLIRRCASIAGSLVRPSARDSSMEDQQCLKRKRTQTLDSQYCSPLSPSSSSKRYRIRPREPIERMRRQ
Protein: Redox-sensing transcriptional repressor Rex (Q9WX14)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Function: Modulates transcription of respiratory genes in response to changes in cellular NADH/NAD(+) redox state. May play a general role as a sensor of cellular redox balance.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Glutamyl-tRNA reductase
- uroporphyrinogen-III C-methyltransferase
- Porphobilinogen deaminase 1
- Ribonuclease P protein component
- Redoxin
Sequence:
MATGRAHRPATRSRGIPEATVARLPLYLRALTALSERSVPTVSSEELAAAAGVNSAKLRKDFSYLGSYGTRGVGYDVEYLVYQISRELGLTQDWPVVIVGIGNLGAALANYGGFASRGFRVAALIDADPGMAGKPVAGIPVQHTDELEKIIQDDGVSIGVIATPAGAAQQVCDRLVAAGVTSILNFAPTVLNVPEGVDVRKVDLSIELQILAFHEQRKAGEEAAADGAAPPVAARKQQRSTGSADQGPDGDVPAVMPA
Protein: Nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1) (EC 2.7.7.18) (A0A0B4KHH7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSAFIEETKSLLPRIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHINSGGGGGDDGENTHLPGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNFKSKYITDAVRPNHLLFNHAYTDNNKNANSYSIGDQLEQDMDESDTPSPQLQHTPTSRVFCCGEVPLRGSKVLRSGPGQAVQVITMQADEKEESQAKKQKISQVQL
Protein: Protein FAM72D (Gastric cancer up-regulated protein 2) (Q6L9T8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSTNICSFKDRCVSILCCKFCKQVLSSRGMKAVLLADTEIDLFSTDIPPTNAVDFTGRCYFTKICKCKLKDIACLKCGNIVGYHVIVPCSSCLLSCNNRHFWMFHSQAVYDINRLDSTGVNVLLRGNLPEIEESTDEDVLNISAEECIR
Protein: Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-) (Q9EP89)
Organism: Mus musculus (Mouse)
Function: Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (By similarity). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (By similarity). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (By similarity). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P83111}.
Interaction partners:
- NSFL1 cofactor p47
- UBX domain-containing protein 2A
Sequence:
MYRLLSSVTARAAATAGPAWDGGRRGAHRRPGLPVLGLGWAGGLGLGLGLALGAKLVVGLRGAVPIQSPADPEASGTTELSHEQALSPGSPHTPAPPAARGFSRAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVALAKLWEAGKLDLDLPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDIKKVKEEKAYKALKMVKGTPPPSDQEKELKEKGGKNNEKSDAPKAKVEQDSEARCRSAKPGKKKNDFEQGELYLKEKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLLAAIVERASGYKYLDYMQKIFHDLDMLTTVQEENEPVIYNRARFYVYNKKKRLVNTPYVDNSYKWAGGGFLSTVGDLLKFGNAMLYGYQVGQFKNSNENLLPGYLKPETMVMMWTPVPNTEMSWDKEGKYAMAWGVVEKKQTYGSCRKQRHYASHTGGAVGASSVLLVLPEELDSEAVNNKVPPRGIIVSIICNMQSVGLNSTALKIALEFDKDRAD
Protein: Cyclin-dependent protein kinase inhibitor SMR2 (Protein SIAMESE-RELATED 2) (Q9SGE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cyclin-dependent protein kinase (CDK) inhibitor that restricts cell proliferation and cooperates with SIM and SMR1 to promote endoreplication during leaf development.
Subcellular location: Nucleus {ECO:0000269|PubMed:17098811}.
Interaction partners:
- Cyclin-dependent protein kinase inhibitor SMR1
- Cyclin-dependent protein kinase inhibitor SMR11
- Cyclin-B2-4
- Cyclin-dependent kinase B1-1
- Cyclin-dependent protein kinase inhibitor SMR3
- Cyclin-dependent protein kinase inhibitor SMR4
- Cyclin-dependent protein kinase inhibitor SMR5
- Cyclin-dependent protein kinase inhibitor SMR6
- Cyclin-dependent kinase A-1
- Cyclin-dependent protein kinase inhibitor SMR7
Sequence:
MSKLLETLEEEKTVEQKPRSQEEEDHQDSSKKEELLESLCTPTSSDHKIPEVETCPPPPRKRPREISLTKKTRLSKDLRFFEATDVGSQEVETLFVHEPNHVRKKRRSNSA
Protein: Large ribosomal subunit protein uL18 (60S ribosomal protein L5) (A0A2R8Y6J3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFL
Protein: Dehydration-responsive element-binding protein 2D (Protein DREB2D) (Q9LQZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity-inducible transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA binding protein
- Protein kinase superfamily protein
- E3 ubiquitin-protein ligase makorin
Sequence:
MSSIEPKVMMVGANKKQRTVQASSRKGCMRGKGGPDNASCTYKGVRQRTWGKWVAEIREPNRGARLWLGTFDTSREAALAYDSAARKLYGPEAHLNLPESLRSYPKTASSPASQTTPSSNTGGKSSSDSESPCSSNEMSSCGRVTEEISWEHINVDLPVMDDSSIWEEATMSLGFPWVHEGDNDISRFDTCISGGYSNWDSFHSPL
Protein: Killer cell lectin-like receptor subfamily C, member 1 (E9QAJ6)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MSNERVTYAELKVAKNSRNQHRKPRGPRSSISVIEQEIIYSDFSFQNPSQEHPWICRNCPCKDTEAKAQINSSMTRTHRDINYTLSSAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLVSCISKNCSLLYIDSEEEQDFLQSLSLISWTGILRKGRGQPWVWKEDSIFKPKIAEILHDECNCAMMSASGLTADNCTTLHPYLCKCKFPI
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F4KFD4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDGADGTVRVKPGRGFETETDVAVSSPVTRQKAAAAKQFIENHYKNYLQGLHERMERRREFQRKVQEAQLPVEEQDEMMRNLARRETEYMRLQRRKIGIDDFELLTVIGKGAFGEVRLCRLRSTSEVYAMKKLKKTEMLSRGQVEHVRSERNLLAEVDSRYIVKLFYSFQDSECLYLIMEYLPGGDIMTLLMREDILSEDVARFYIAESILAIHSIHQHNYVHRDIKPDNLILDKSGHLKLSDFGLCKPLDDKYSSLLLEDDEMLSQDSENQSGKSDADKAPWQMPKEQLLQWKRNRRALAYSTVGTLDYMAPEVLLKKGYGMECDWWSLGAILYEMLVGYPPFCSDDPRITCRKIINWRVCLKFPEEPKISDEARDLICRLLCDVDSRLGTRGVEEIKSHPWFKGTPWDKLYDMEAAYRPIVDGELDTQNFEKFPEVEGSPSEAPQVGPWRKMLTSKDTNFIGFTFKKSDITRSMESSGSADMKSNGSGEAPSLISLLGRINMEEGEGGELNHKT
Protein: Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) (P48526)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Leucine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase, mitochondrial
- Arginine--tRNA ligase, mitochondrial
- Arginine--tRNA ligase, cytoplasmic
- Methionine--tRNA ligase, mitochondrial
- Probable proline--tRNA ligase, mitochondrial
- Putative proline--tRNA ligase YHR020W
- Glutamine--tRNA ligase
- Methionine--tRNA ligase, cytoplasmic
Sequence:
MKRSRLVPQHIFSIISKRYLAKHAYQKTLNLPKTKFPNRSNLEITLRELIPKSSQLVYKEQLRDFFEEFSKLNTTDEKLEFIKEKLFILHDGPPYANGELHLGHALNKILKDIINRYQLSQGKYIFYKPGWDCHGLPIEIKALKDLSAQQIESISPLKIRSMALKHAQKAIKRQRETFQHFAILTDWETPYLTMDKDYEINQLNIFKEMYERGLIKRQNKPVYWGTETRTALAEGELEYNENHKSIAAYVKFPLEKKSQMDLCKKLGITNNLPIYCLIWTSTPWTLLSNRAICFNQDFSYSLLRLNSELILVETGSIDKLGLTTNSFETIKQFQGTHLNGLYYQNLLVDDKVGRPLLHGAHVTSGTGTGLVHTAPGHGQDDYLIGIQNGLEIYSPVDHQGRYQLNELPQSVRSIVRDEGDLTKGRQVLDAETAKIILCKLSDLNLLYKSHEYTHSYPYDWRSKKPVIIRATPQWFADLHDVKNLALESISRVKFCPKRGYSRLSSFMKSRNEWCISRQRSWGIPILSFYKKSEPDSVLMNSEILAHAIEKIKQKGINAWFNDKDNDMKEWLPEKYHDVAHEYCRSQDTMDVWFDSGSSWSVIKDFYEKSLKLSKLPSPLYQVCLEGSDQHRGWFQSSLLTKVASSNVPVAPYEEVITHGFTLDENGLKMSKSVGNTISPEAIIRGDENLGLPALGVDGLRYLIAQSNFTTDIVAGPTVMKHVGEALKKVRLTFRYLLSNLQKSQDFNLLPIEQLRRVDQYTLYKINELLETTREHYQKYNFSKVLITLQYHLNNELSAFYFDISKDILYSNQISSLARRQVQTTLVHILNAYRAILAPILPVMVQEVWKYIPEGWLQGQEHIDINPMRGKWPFLDSNTEIVTSFENFELKILKQFQEEFKRLSLEEGVTKTTHSHVTIFTKHHLPFSSDELCDILQSSAVDILQMDDNNNSLPTIELGSGINVQILVERSKRHNCPRCWKANSAEEDKLCDRCKEAVDHLMS
Protein: Flagellar motor switch protein FliN (P15070)
Organism: Escherichia coli (strain K12)
Function: FliN is one of three proteins (FliG, FliN, FliM) that form a switch complex that is proposed to be located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
Subcellular location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Interaction partners:
- Flagellar basal-body rod protein FlgG
- Flagellar assembly protein FliH
- Flagellum-specific ATP synthase
- Flagellar hook-length control protein
- Flagellar biosynthetic protein FliQ
- Flagellar protein FliO
- Flagellar basal-body rod protein FlgC
- Flagellar M-ring protein
- Flagellar basal body rod protein FlgB
- Flagellar biosynthetic protein FliP
Sequence:
MSDMNNPADDNNGAMDDLWAEALSEQKSTSSKSAAETVFQQFGGGDVSGTLQDIDLIMDIPVKLTVELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVADKYGVRITDIITPSERMRRLSR