wanglab/gogpt-training-data huggingface dataset:
Protein: Bacterial surface antigen (D15) domain-containing protein (Q580K4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004374}.
Interaction partners:
- Elongation factor Ts, mitochondrial
- tyrosine--tRNA ligase
Sequence:
MTFSSESSVPPQEVYIGEEDIGKVLNVPIRTHVRIRGIENIHPRVISRDVEAIKRSENIEDITNNMNEARTRWARMGIFSKVDFNLEPTFHGESNDVCVHIDVVEAKPKKTFGVFTTETVLPELTLSLENILGGRYSLSGSYVPPTSRAHAVSLSMLSNATYLGQTGEYYLGRRSENKMYHLASNERIDEVKATTRNEKRGLLSEFTIGFQRRLLVSREGTNLPDEMLQDFRTTFKGYFRHELGVSNVWHHADPYLCGIYPLPIKGVQLSMKNELAGGPLGGGFNFLKTEIQTAKYWPLGPFCSVQWNSKVAGIWSYKRARIPLSDRLFLSSCHVRGFRSVGPSTVDGGVREGGHFAATGGNALWATSLSVNFPFLFFPNNGLAAMHLFGNVGNLRMVNSSSELFDTYRWFRTCAASVGFGIVVTRVPLFGVTPNGRFELNFCVPVGVDGRGNITWRNGNNRLFDHVKFGLTWSSAFSM
Protein: ABC transporter C family member 14 (ABC transporter ABCC.14) (AtABCC14) (EC 7.6.2.2) (ATP-energized glutathione S-conjugate pump 10) (Glutathione S-conjugate-transporting ATPase 10) (Multidrug resistance-associated protein 10) (Q9LZJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pump for glutathione S-conjugates.
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Interaction partners:
- ABC transporter G family member 39
- ABC transporter F family member 3
- ABC transporter F family member 1
- ABC transporter E family member 2
Sequence:
MRWLSSTWLSDLSCSSSSVIEPSSSLPAPIQWLRFILLSPCPQRLLSSTVDVLFLLILFFFAIQKLCSSSSSRTNGEADITKPLLGRRTRTRTTGLFKTTVVVTIVLSFCSLVLCVSAFFTTRTKLKLVDTLFWLIHAVTNVVIAVLVLHLKRFASPSHPLTLRIYWVFNFVVTTLFTVSGILHLLSDDPAAASLRADDVASFISFPLTAVLLLVSIKGSTGVVVTTSNVTAPAKSNDVVVEKSENVSLYASASFISKTFWLWMNPLLRKGYKSPLNLDQVPTLSPEHRAEKLATLFESKWPKPQENSRNPVRTTLIRCFWKEIAFTAVLAIIRLSVIYVGPVLIQSFVDFTSGKRSSPSQGYYLVLILLIAKFVEVLSTHQFNFNSQKLGMLIRSTLITALYKKGLKLTGSARQNHGVGQIVNYMAVDAQQLSDMMLQLHAIWLMPLQVAAAIVLLYNTLGPSVVTTVIGLTGIFVFILLGTKRNNRYQFSLMMNRDSRMKATNEMLNYMRVIKFQAWEDHFNERILKFREMEFGWLSKFLYSIAGNIIVLWSTPVLISALTFTTAVFLGVKLDAGTVFTTTTIFKILQEPIRTFPQSMISLSQAMISLGRLDAYMMSRELSEETVERSQGCDGNVAVEIKDGSFSWDDEDDEPAIENINFEVKKGELAAIVGTVGSGKSSLLASVLGEMHKLSGKVRVCGTTAYVAQTSWIQNGTVQDNILFGLPMNRSKYNEVLKVCCLEKDMQIMEFGDQTEIGERGINLSGGQKQRIQLARAVYQESDVYLLDDVFSAVDAHTGSDIFKKCVRGALKGKTILLVTHQVDFLHNVDRILVMRDGMIVQSGKYDELVSSGLDFGELVAAHETSMELVEAGSASATAANVPMASPITQRSISIESPRQPKSPKVHRTTSMESPRVLRTTSMESPRLSELNDESIKSFLGSNIPEDGSRLIKEEEREVGQVSFQVYKLYSTEAYGWWGMILVVFFSVAWQASLMASDYWLAYETSAKNEVSFDATVFIRVYVIIAAVSIVLVCLRAFYVTHLGLKTAQIFFKQILNSLVHAPMSFFDTTPSGRILSRASTDQTNVDIFIPFMIGLVATMYTTLLSIFIVTCQYAWPTVFFIIPLGWLNIWYRGYYLASSRELTRLDSITKAPVIHHFSESIAGVMTIRAFKKQPMFRQENVKRVNANLRMDFHNNGSNEWLGFRLELIGSWVLCISALFMVMLPSNIIKPENVGLSLSYGLSLNGVLFWAIYLSCFIENKMVSVERIKQFTDIPAEAKWEIKESRPPPNWPYKGNIRLEDVKVRYRPNTPLVLKGLTIDIKGGEKIGVVGRTGSGKSTLIQVLFRLVEPSGGKIIIDGIDICTLGLHDLRSRFGIIPQEPVLFEGTVRSNIDPTEKYSDEEIWKSLERCQLKDVVASKPEKLDSLVADNGENWSVGQRQLLCLGRVMLKRSRILFLDEATASVDSQTDAMIQKIIREDFSDCTIISIAHRIPTVMDCDRVLVIDAGKAKEYDSPVRLLERQSLFAALVQEYALRSAGI
Protein: Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma) (O08950)
Organism: Rattus norvegicus (Rat)
Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Transcription initiation factor IIA subunit 1
- TATA box binding protein
- General transcription factor IIF subunit 2
- General transcription factor IIA, 1-like
- Transcription initiation factor IIB
- General transcription factor IIH subunit 3
- Transcription initiation factor IIE subunit beta
- General transcription factor IIE subunit 1
- General transcription factor IIF subunit 1
- Transcription initiation factor TFIID subunit 11
Sequence:
MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINSALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE
Protein: Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) (P24964)
Organism: Sus scrofa (Pig)
Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00157}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00157}.
Interaction partners:
- Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
- NADH-ubiquinone oxidoreductase chain 5
- Cytochrome b-c1 complex subunit 1, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- Cytochrome c oxidase subunit 2
- Ubiquinol-cytochrome c reductase complex III subunit VII.
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 6
- Cytochrome b-c1 complex subunit 10
Sequence:
MTNIRKSHPLMKIINNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWVIRYLHANGASMFFICLFIHVGRGLYYGSYMFLETWNIGVVLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFILPFIITALAAVHLLFLHETGSNNPTGISSDMDKIPFHPYYTIKDILGALFMMLILLILVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVASILILILMPMLHTSKQRGMMFRPLSQCLFWMLVADLITLTWIGGQPVEHPFIIIGQLASILYFLIILVLMPITSIIENNLLKW
Protein: Ubiquitin-like domain-containing protein (Q9TZ84)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPPTVGKSTNKDGPSDLMSAFENLRSETAGINNFLEKGPTIGSITSLSISKFDKFCENQDKVNQKLMLAIQKMSIERSKRQKIQDAFNKEMLDAIRSMKKAFAREKEEFSDDLEIFKEELFEKLDEDNETSEDEDEEEENDVLDAIKLLQTGLDAMKEAQREFFKKVTEDTQAIRRKIGSKNIKFNVILHGSRIPMELDSLDTIYTVGMALLKHGGLALHRQRLMLNDKELQYNQTLEEAGIKDGSVIKQHTDEKCDEDCECCC
Protein: Actin-related protein 2/3 complex subunit 4 (F4JUL8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR039100}.
Interaction partners:
Sequence:
MANSLRLYLACIKNTLEAAMCLQNFPCQEVERHNKPEVELKTSPELLLNPVLICRNEAEKCLIETSINSLRISLKVKQADELENILTKKFLRFLSMRAEAFQVLRRKPVQGYDISFLITNYHCEEMQKQKLIDFIIQFMEARYRERNKGLEGVSEYKRKTRCYGVLETVHVKQLLK
Protein: 4-hydroxylaminobenzoate lyase (EC 4.3.3.-) (Q9FD33)
Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
Interaction partners:
Sequence:
MNKRDELIGLCIDFLAKVKDKTANANIERWLNENYGPDSETYQKISTLVIDGVAEGWAANDEISGPHYRRSRLCEPCAETFYFSITAVYMDSKGHELDNQQRTFRGDYHSHPYGELNMVIPLDEGAVLAGPLGWQGAGWTAPAPGSQHYPEVKNGALIAFFFLPAGRISYDFQAQG
Protein: Netrin-A (Q24567)
Organism: Drosophila melanogaster (Fruit fly)
Function: Netrins control guidance of CNS commissural axons at the midline and peripheral motor axons to their target muscles.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Netrin receptor unc-5
- Roundabout 1, isoform A
Sequence:
MIRGILLLLLGTTRFSPIQCISNDVYFKMFSQQAPPEDPCYNKAHEPRACIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDHERSCHTCDMTDPLRSFPARSLTDLNNSNNVTCWRSEPVTGSGDNVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIYKSTDHGLSWQPFQFFSSQCRRLFGRPARQSTGRHNEHEARCSDVTRPLVSRIAFSTLEGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAGNNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTDASGQLNCECSHNTAGRDCERCKPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLSQGVSGGVCQNCRHSTTGRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKICNSTSGQCPCKDGVTGLTCNRCARGYQQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSGGDRNGAAGMAAQSQYYRTEGGRECGKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSREVQRRAMDPDVADYEMDQVQPGSARSPITGVYEFQAADYPNPNPNPRGSEMERFDLQIQAVFKRSRPGESSGAGNVYGMPNTTLKRGPMTWIIPTKDLECRCPRIRVNRSYLILGRDSEAPPGYLGIGPHSIVIEWKEDWYRRMKRFQRRARTCA
Protein: GMP phosphodiesterase delta subunit domain-containing protein (C0P283)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPRPPPVTEQAITTEAELLAKNQITPNDVLALPGITQGFLCSPSANVYNIEFTKFQIRDLDTEHVLFEIAKPENETEENLQAQAESARYVRYRFAPNFLKLKTVGATVEFKVGDVPITHFRMIERHFFKDRLLKCFDFEFGFCMPNSRNNCEHIYEFPQLSQQLMDDMINNPNETRSDSFYFVENKLVMHNKADYSYDA
Protein: Activator of transcription and developmental regulator AUTS2 a (A0A2R8RIS2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MFASPAALPPPPPLTSNTLPVPGHPAGSAYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHQHQHTHQHTHQHTFTPFPHAIMPTPAPPMVRTPARNFEKYPTKVDPFYRHSLFHSYPPAVSGIPPVIPPTGPFGSLQGAFQPKTSNPLDVAARPGAVPHTLLQKDPRLTDPFRPVLRKPGKWCAMHVHIAWQIYHHQQKVKQMQVDPHKLDFGLKPEFLSRPPGPTLFGAIHHPHDLARPASLFSAAGSTHPAAAPFGHPPHHPSNFLTPAPHLEPFSRPPSFGGLASLSTAAFGGLGNPALASNSVFGHKDSPSAQQHFSGPHEPWNRLHRTPPSFPTPPPWLKPGESERSASVSSHERERERDRERERDLDKRDSSVNKDDKEREPVEKRHQNHQSPLPVNPLTLLGHTRPSEPSRNHISSSEPRDKDKDKPKDRERDREHSDWKDSNTDEHKLKENHHSDKDTPVIHDGRVSEDKPANRITASPYMRPGGMDRVNGGLTRDILEKKAEITYEKKNSEVKVKEERKEEQDGPTERSPEQRSTPQAPPPPPPAALHPPSSMPVPMGMASMHPINSISSLERTRMVAPFMGISPIPGAERFPYPAFHWDPMRDPYRGLDIHRRDPLARELLLRNDPLHRLAAPRLYEAERSYRDREPHDFNRDHPHGLTLEQRREQERAHLEERERLHLLREDYEQGRLHPMHHPVLDGHLPHPGLMAPGLPSMHYPRVSPSSAVAAAAQNGILNKTPPTASLSAPPPLIPTLGARSSSPRRTTPLGPDIRDRPPSHTHKDIEAR
Protein: Unconventional myosin-Ib (MIH-L) (Myosin I alpha) (MMI-alpha) (MMIa) (P46735)
Organism: Mus musculus (Mouse)
Function: Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.
Interaction partners:
- Actin, alpha skeletal muscle
- Calmodulin-1
- EF-hand domain-containing protein
Sequence:
MAKMEVKSSLLDNMIGVGDMVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLYKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFLDHEAEAVLEVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTSIDQVVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHSLIKSLFPEGNPAKVNLKRPPTAGSQFKASVATLMRNLQTKNPNYIRCIKPNDKKAAHIFNESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEHSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRELKHQKRCKEAATTIAAYWHGTQARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP
Protein: Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (A1A766)
Organism: Escherichia coli O1:K1 / APEC
Function: Acts as a chaperone.
Interaction partners:
Sequence:
MGKIIGIDLGTTNSCVAIMDGTTPRVLENAEGDRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRRFQDEEVQRDVSIMPFKIIAADNGDAWVEVKGQKMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKGTGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFDSRLINYLVEEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDIDDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGVLTGDVKDVLLLDVTPLSLGIETMGGVMTTLIAKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGERKRAADNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEDEIQKMVRDAEANAEADRKFEELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALTALETALKGEDKAAIEAKMQELAQVSQKLMEIAQQQHAQQQTAGADASANNAKDDDVVDAEFEEVKDKK
Protein: Cytochrome P450 734A6 (EC 1.14.-.-) (B9X287)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Cytochrome P450 involved in brassinosteroids (BRs) inactivation and regulation of BRs homeostasis. Is a multifunctional and multisubstrate enzyme that controls the endogenous bioactive BR content both by direct inactivation of castasterone (CS) and by decreasing the levels of BR precursors. Catalyzes the oxidation of carbon 22 hydroxylated BR intermediates to produce C26 oxidized metabolites.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 85A1
- Cytochrome P450 734A5
- Os09g0441625 protein
- Os09g0441400 protein
- Os09g0441600 protein
- Nitrate reductase 1
- Nitrate reductase
- Nitrate reductase
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- 4-coumarate--CoA ligase
Sequence:
MGWWGWAAAAAAAAAWVAVKVLEVLWWRPRRVEEHFARQGITGPRYRFLVGCVREMVALMVAASAKPMPPPYRSHNVLPRVLAFYHHWKKIYGSTFLIWFGPTPRLAIADPELIREVLLARADRFDRYESHPMVRQLEGEGLVSLRGDKWAHHRRVLTPAFHMDNLRLLLPCVGMTVLDMADKWRAMAEADKSGEVEIDVSDWFQVVTEDAITRTAFGRSYEDGKVVFKLQAQLMAFASEAFRKVFIPGYRFLPTKKNTSSWKLDKEIRKNLVTLIGRRQEAGDDEKLDGCAKDLLGLMINAAASSNGGKRSALPVSPITVNDIVEECKTFFFAGKQTTSNLLTWAIVVLAMHPEWQERARQEVLDVCGADGVPSREQLAKLKTLGMILNETLRLYPPAVATVRRAKADVELGGYLRIPRDTELLIPIMAVHHDARLWGPDAAQFNPARFAGGVARAARHPAAFIPFGLGARMCIGQNLAILEAKLTVAVILHRFEFRLSARYVHAPTVLMLLHPQYGAPIVFRPRSSSQPTCEKMNPLTSS
Protein: Ephrin-A2 (EPH-related receptor tyrosine kinase ligand 6) (LERK-6) (HEK7 ligand) (HEK7-L) (O43921)
Organism: Homo sapiens (Human)
Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Ephrin type-A receptor 1
- Ephrin type-A receptor 2
- Ephrin type-A receptor 4
- Ephrin type-A receptor 3
- Ephrin type-A receptor 5
- Ephrin type-A receptor 7
- Ephrin type-A receptor 8
- Ephrin type-A receptor 10
- Disintegrin and metalloproteinase domain-containing protein 10
- Tyrosine-protein kinase Fyn
Sequence:
MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
Protein: U4/U6 small nuclear ribonucleoprotein PRP4 (Pre-mRNA-processing protein 4) (P20053)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in RNA splicing. Is required for the association of U4/U6 snRNP with U5 snRNP in an early step of spliceosome assembly.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-mRNA-splicing helicase BRR2
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein E
- LSM complex subunit LSM6
- LSM complex subunit LSM7
- Small nuclear ribonucleoprotein Sm D2
- 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component
- Pre-mRNA-splicing factor 6
- U4/U6 small nuclear ribonucleoprotein PRP3
- Pre-mRNA-splicing factor 8
Sequence:
MSKYIALENLPVDLQHKGATQNESTADILKQLPHERLQAVLEKIPEEDLEVRRLLSILKKPEVVENEDVQQRRIRLAEILMVDEIDLENINNMENINGEEVDEEDDEDFFTPATSELIFARRFLINYSLERSRKRLQKEMERHQKFNTRQELLSRRTELQRMANLELAGSQLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN
Protein: Cholinergic receptor nicotinic alpha 2 subunit (A0A0X1KG79)
Organism: Homo sapiens (Human)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
Sequence:
MAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
Protein: Lysyl oxidase homolog (EC 1.4.3.13) (Q6NYT8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239, ECO:0000256|RuleBase:RU367046}.
Interaction partners:
- Developmental arteries and neural crest EGF-like protein
- Elastin b.
Sequence:
MSMSLIDTFIYAFAHVCLLSCIAQTGQTQRQGNTGAAALRQTIQWQHNGKLFSILSQGSEYQPPLKRDGNKEQAQARPVAIVRNDDAATRTDSSAPSRASQSRGSVRVPSGTGARGGASRWLSGDGARTRGVHGRRNHTDPLRSINGTDRPAGDDEVMVGDDPYNPYKSTDPDNPYYNYYDTYERPRPAQRPGYGTGYFQNGLPDLVGDPYYIQASTYVQRVPMYNLRCAAEENCLASSAYRSSVRDYDMRMLLRFPQRVKNQGTSDFLPSRPRYTWEWHSCHQHYHSMDEFSHYDLLDATTHRRVAEGHKASFCLEDTSCDYGYYRRYACTSHTQGLSPGCYDTYNADIDCQWIDITDVKPGNYILKVSVNPSYQVPESDYSNNVVRCDVRYTGNYAYVSGCHISQY
Protein: Folliculin-like protein bhd1 (O74769)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized protein C30C2.07
- GTP-binding protein gtr1
- GTP-binding protein gtr2
- Ypt/Rab-type GTPase ypt71
- Uncharacterized protein C1778.05c
- V-type proton ATPase subunit C
- Uncharacterized protein C29A10.17
- Uncharacterized protein C23D3.16
- Uncharacterized protein tam1
- V-type proton ATPase subunit D
Sequence:
MDVVFALGHFCEAEGPSIIFCTQKLHRSTVSKFFEHPTSKRSIGVTENGNDSPEAFKNELDNRNNADSQSLQSSTESLFKADSEDYLCKKVSKGPESPRVNSFHNSYSRNQSPISRKSSCVTCSTVLPLEFSVPDVQPRLYTNSSTNPDVLYMSSQHPHTQQRYSTLKRLMVRCLSCEYSTLSEASDSMSNPLFFGDQDNGYVISQSFSLRDPSARGGLRRYAIIATCPNQLDLILRYSFISEKFLHIVQFLRISSFNTKNDYSSSRSKTTASSSNGTFASPSFNISSLSGSSNIGTAPSYEISSSIGANVSSLAHTQRLPSFSFLRRRDDIGEGRSLVDITCWDGIFVGLHSSFSWILEVWDLLVV
Protein: Ubiquitin-like protein NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (P29595)
Organism: Mus musculus (Mouse)
Function: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12215427}. Note=Mainly nuclear. {ECO:0000269|PubMed:12215427}.
Interaction partners:
- Cullin-1
- E3 ubiquitin-protein ligase RBX1
- NEDD8-conjugating enzyme Ubc12
- NEDD8-activating enzyme E1 catalytic subunit
- Sentrin-specific protease 8
- NEDD8-activating enzyme E1 regulatory subunit
- NEDD8-conjugating enzyme UBE2F
- Cullin-2
- Cullin-5
- Elongin-C
Sequence:
MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLGQ
Protein: Sperm protein associated with the nucleus on the X chromosome A (Cancer/testis antigen 11.1) (CT11.1) (Nuclear-associated protein SPAN-Xa) (SPAN-X) (SPANX-A) (SPANX family member A) (Q9NS26)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10906052}. Nucleus {ECO:0000269|PubMed:10906052}. Note=Associated with nuclear craters.
Interaction partners:
- Sperm protein associated with the nucleus on the X chromosome N4
- A-kinase anchor protein 4
- Translin
Sequence:
MDKQSSAGGVKRSVPCDSNEANEMMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNFKRTSPEELLNDHARENRINPLQMEEEEFMEIMVEIPAK
Protein: (-)-5-epieremophilene synthase STPS2 (EC 4.2.3.199) (Sesquiterpene synthase 2) (SmSTPS2) (A0A1W6GW06)
Organism: Salvia miltiorrhiza (Chinese sage)
Function: Sesquiterpene synthase that catalyzes the conversion of farnesyl diphosphate to (-)-5-epi-eremophilene.
Interaction partners:
Sequence:
MATTQVEIQRPIANFSPSLWGDQFIKNDSGAKAAEKHCKAVEELKKEVMNMITAGGSNLVEAMNLIDTLERLGISYHFEKEIDQKLNHFFNLNTDYSDEFYDLYTVSLHFRLFRQHGHRISSDIFGRWIDESGKFKEGLKTDGKGLLSLYEASYLRTRGETILDDALEFATATLNSIAPHLESPLSKQVVHALIQPLHYGNPRIEAHNFISIYEENQDKNEFLLKFAKLDYNLLQMLHKEELHEVSRWWKELDLVSKLPYARDRVVECFFWAMGVYHEPQYSRARIMLTKTITMTSIIDDTYDAYGVIEELDIFTEAIERWNIEEMDRLPEYVKPFYKALLELYEQFEEELAEEGRSYAAHYAIESLKELVRSYHVEAKWFIQGYLPPFEEYLKNALITCTYCYHTTTSLLGVESAVEEDFQWLAKKPKMLVAGLLICRVIDDIATYEVEKERGQSATGIESYMRDNNATIEEAVAKFFEIATDAWKDINEECLMPSPYSRDVLMRILNLERIIDVTYKGNEDGYTQPEKVLKPHIIALFVDPIKM
Protein: Nephrocan (Q9CQ76)
Organism: Mus musculus (Mouse)
Function: May inhibit TGF-beta signaling.
Subcellular location: Secreted {ECO:0000269|PubMed:16990280}.
Interaction partners:
- Semaphorin-3A
- Neural cell adhesion molecule L1
- Neuronal cell adhesion molecule
- Plexin-A3
- Death domain-containing membrane protein NRADD
Sequence:
MHPLWAFLLGLSLTNGLSANCPGRCSCDSMQSVQCYRLMELPSGIPSTTKRLYISHSRIQHLQLSNFTGLLALEDFILLASGTESIENDTFKTLSTLKTLELWKNKLRQVPSALPANLEVLKLNDNAICALRGSEFEGLKNLKVLELKNNLISSLSPSMLSPLASLQSLMVDGNNIESVVGPLSLPHLKYMSMENNQLHLIPGNVFTSLQNLQFLSFSGNFLTKIPINLPKSLLSLKMERNQLKVVRFRDMKHLENLSHLYLSENFLSSIDGAQQLTNLTTLEVSQNQLQMLPPRLPSRLQKLDCSSNFIQRVTAPEFQDLRDLKHLFLDNNVVSLFEAGALQRCSQLSNLALEQNLLLSIPLRLPKTLARLDLKGNAIQDMAERELRDLKQLQVLNLRNNRISALDFKALEGLPRLRHLYLDGNPWNCTCSLLRAREVLKAKGTDVKGGQCAAPAERQGESWMSSKKILRQCEHHLQQSEKSKETKKKPKPEDSSSIRLNMDDDDDDYEID
Protein: Radial spoke head protein 9 homolog (Q27YU5)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Subcellular location: Cell projection, kinocilium {ECO:0000256|ARBA:ARBA00037822}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000256|ARBA:ARBA00004611}.
Interaction partners:
- Uncharacterized protein
- Radial spoke protein 10
- Uncharacterized protein
- Uncharacterized protein
- Nucleoside diphosphate kinase 6
- Uncharacterized protein
- Radial spoke protein 11
- Uncharacterized protein
- Uncharacterized protein
- Radial spoke protein 14
Sequence:
MVQLEPNITLVLKHLASCGAVVSAEQQAALDHSIPIKRIEAGLRSLTLWGRLTTLNGKDYLVAEGYNVASSKEGAAVYETKYFYSQDGARWSDLQPVDSETATRCARIKGMLSGDPAKNYELEEKDPNAPEPSPEAEEEVKPLVFQIPELAVLRCRVDAIATATSVIPTDSTILNAASQVVPNRLFAGAAYPEKLESYQHRFSLPGSGVTLSQDLRGTWAVQYDAFKGVAQVRSLLFPGYFFYYAANELTWGSLYVGDGLRNNDLIFML
Protein: High mobility group AT-hook 2 (O88791)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Insulin-like growth factor 2 mRNA-binding protein 2
- Mothers against decapentaplegic homolog 3
- High mobility group protein HMG-I/HMG-Y
- Mothers against decapentaplegic homolog 4
- Mothers against decapentaplegic homolog 2
- SNW domain-containing protein 1
- Cellular tumor antigen p53
- Mothers against decapentaplegic homolog 1
- Lin-28 homolog B
- Mothers against decapentaplegic homolog 7
Sequence:
MSARGEGAGQPSTSAQGQPATPAPQKRGRGRPRKQPQEPTCEPSPKRPRGRPKGSKNKSPSKAAQKKAETIGEKRPRGRPRKWPQQIVQKPAQETEETSSQESAEED
Protein: Ras-related protein RabG1 (Q54E92)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
Sequence:
MNDSDVFKILLIGDSAVGKTSLLLRFTDPNNFQETSVNMTSVDYKNKNITIDGRTFNLQIWDTAGQERFRTITSSFYRGAHGVLVCYDVTDQLTYNNVGLWMQEIQRYGVLGVSRVLVGNKCDLEDRKLVNASIAQEYADILGIPFIETSATTGVNVEEAFMAMADEIYRNHIGGSKPSVVKPVCGSPPRTKKNIC
Protein: Aminopeptidase N (EC 3.4.11.2) (B4DP01)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGKEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK