wanglab/gogpt-training-data huggingface dataset:
Protein: Protein TBF1 (TBF-alpha) (TTAGGG repeat-binding factor 1) (Q02457)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. 52 binding sites have been identified, distributed over 15 chromosomes. A member of the general regulatory factors (GRFs) which act as genome partitioners. Acts as a chromatin insulator which are known as STARs (Subtelomeric anti-silencing region). STARs prevent negative or positive transcription influence by extending across chromatin to a promoter.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:10871401}. Chromosome, telomere {ECO:0000269|PubMed:10871401}. Note=Localizes to synapsed chromosomes during meiosis.
Interaction partners:
- Vacuolar import and degradation protein 22
- ARS-binding factor 1
- Late endosome and vacuole interface protein 11
- DNA-binding protein RAP1
- DNA-binding protein REB1
- Pheromone receptor transcription factor
- Protein IFH1
- Putative uncharacterized protein YDR544C
- Putative uncharacterized protein YBL109W
- Histone H2B.1
Sequence:
MDSQVPNNNESLNRFNDIIQSLPARTRLTICSLCLLDNISTQLLRFLILNANSPNIIAVLTDQTAFLSSGETEIFQTLVKLFKQIRMIYHTRSPLLSVHDVAPGLWFPNSPPPLILRGHEAFIITAIRKANLLTFLLTSLNCLNYGFELLQSIFLDIFCPNTNTVGNNSLEQSGKFLKSQAILYLDLKTQAYIAGLKEFQDETNEISLEKKQELLDLIFPSNLADILVQRRTGDSGDITLLTPSEKDFVERCDRRRENLKIVQDFNSLTQSYEWAQFIRELLDYCNKNMGLIIWGRKGRGKSPLYDFDVNEFDPQVLFSTGTRTVEFMDDQNQPSSASAFLSTARPNHYSTHTPTTDVSSKNPAITQSIVDAAVAASMSNSSSGPHSSHNNSSNSNNNGSIGLRKPKAKRTWSKEEEEALVEGLKEVGPSWSKILDLYGPGGKITENLKNRTQVQLKDKARNWKLQYLKSGKPLPDYLIKVTGNLEKIYKAKKKFSQSPNSSTIMEQNLSQHPSSAASATEDTQTHQEDSHGQNSDNMPSNGLFGNSTSDNTGFDPHLEDGM
Protein: Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) (P51813)
Organism: Homo sapiens (Human)
Function: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
Interaction partners:
- Signal transducer and activator of transcription 3
- RUN and FYVE domain-containing protein 1
- Caspase-3
- Signal-transducing adaptor protein 1
- Pleckstrin
- Pleckstrin-2
Sequence:
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH
Protein: Small-subunit processome Utp12 domain-containing protein (Q57UQ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Small-subunit processome Utp21 domain-containing protein
- U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein
- Periodic tryptophan protein 2, putative
- U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein
- HEAT repeat-containing protein 1
- Nrap protein domain-containing protein
- U3 small nucleolar RNA-associated protein 15 C-terminal domain-containing protein
- Bms1-type G domain-containing protein
- BING4 C-terminal domain-containing protein
Sequence:
MKVGFMVGKTYLRYVVGPQGGAVASNGSLSCYSSITRPSYAKSTGVAKTTYSERNNRNQGRDKSSTAASAVIFTASLEAVRVYSLRSGVLQHTLIPREGKMPLEVTALRVVPLDMVGTSTASATPLNTLNQIEQEGWMLLVGYHNGHVAVFSCGPTSNYGEPVCRFYALGHKIDTSVLSVAIDSQRACLCSGGQDTDLTVWDVVTQEPSFRLRGHRGGIVGVEFVPQRRPTGRLVVVTGSSDGLIKVWELSIRQCLQTIVASDTQVSSILIDATGSRLYCGLRESQLKVFNTEELTASSEMDKELGAVTEHGGVPRKHQKPITSFSFSYDGNFLLACTSKTVEIFRILSRDDVRRKVARKRKRREAKNSGNAPLNDVAEDDGDEPNAPGDEDRIEEKLPPTRITTDGKSEANDAGSKSTHSAHATAMEEMALLRTFFLDEKVRSACFVPPFPGMSGGRGSGSPGQLHIAVTFNNNTVRTFTTALTCGDPPAAAMWSLENLSMRHTMDYSGHQSDIRSLQFVDDDTTLLSLSSEKLMMWNISTKDPEEDHRNEHDFYDAVEANVKRGDKTGSLTCTSQVALDDAVAVAAIASNLCCVGRKDGSVLLVDLPAAETVFTDTAVHVGGVRHVTPLPDKSGFVSVGADRRMIVWTLAMVKAGSDAASSGSGSQAASHRHKNSSPDTPEPTDENGNGETDTKNMSLQLLQSAQLELTESPLFAVCSADGRFLAVGLQNTNIQLFFADTMKPYLSLYGHKLPPTAATFSTDGTLIASCGMDKALRLWGTDFGDCHRSIHAHDDYVTDVAFFRDTHQLLTVSLDGTLKHWDGDNWIMIQMFRQHQRGVWAVAATANSTCVATAGVDKCIRCFLRTSDIVFPAEEEERLAQEAMDEEAAKRAAMQSLNGIQHQQEVGVAGHATTATAAAAEKIMEALDLVSVELQRRKNDSDSAPPNPLLVNKTVWEYLWSIIESVRPSDLRHALSNLTSTHVDALLDYVEQMLKERAVLNYETAARILLALVGTPASVATTHIARVAVAGEVSEARGARRLAALRRMIAEGLDQSATRMDYNVSGLQFVRKILEDSEKARFFDVSKVQGYKQRYHSRVLHEEQRGEKH
Protein: Small nuclear ribonucleoprotein, putative (Q38BA6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Small nuclear ribonucleoprotein E
- Sm protein F
- Small nuclear ribonucleoprotein Sm D2
- Sm protein G
- Small nuclear ribonucleoprotein SmD1
- Sm protein B
- U2 small nuclear ribonucleoprotein B, putative
- PRP8 protein homologue
- U1 small nuclear ribonucleoprotein, putative
- U5 small nuclear ribonucleoprotein component, putative
Sequence:
MEGVADIPLRAICEATGFLVKVETTDGSVYDGKLMQLDAICGDIELIDVRCQHRDSSLSVEGRVFLKGSSVRLVHLPSDLKRAPFLDWKNLSIQKQLKSSLKASKGGENKWPKRTRMKPTKLEHRKKKLLL
Protein: Diaminopropionate ammonia-lyase (DAPAL) (EC 4.3.1.15) (2,3-diaminopropionate ammonia-lyase) (Alpha,beta-diaminopropionate ammonia-lyase) (Diaminopropionatase) (P66899)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia. In vitro the D-isomer of serine is degraded to pyruvate, though very poorly; other amino acids (L-serine, D- and L-threonine, D- and L-beta-Cl-alanine) are not substrates. In vivo allows poor growth on L-DAP or a DL-DAP mixture but not on D-DAP alone, this may be due to a poor promoter. DL-DAP is toxic in the absence of this enzyme, it may inhibit enzymes involved in the synthesis of pyruvate and aspartate, as well as amino acids derived from them.
Interaction partners:
- Uncharacterized protein YgeY
- Putative carbamoyltransferase YgeW
- D-phenylhydantoinase
- Putative oxidoreductase YgfK
- HTH-type transcriptional regulator MalT
- Allantoate amidohydrolase
- Acetylornithine deacetylase
- Putative aminohydrolase SsnA
- 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenasepropanoate dehydrogenase)
- Recombination-promoting nuclease RpnA
Sequence:
MSVFSLKIDIADNKFFNGETSPLFSQSQAKLARQFHQKIAGYRPTPLCALDDLANLFGVKKILVKDESKRFGLNAFKMLGGAYAIAQLLCEKYHLDIETLSFEHLKNAIGEKMTFATTTDGNHGRGVAWAAQQLGQNAVIYMPKGSAQERVDAILNLGAECIVTDMNYDDTVRLTMQHAQQHGWEVVQDTAWEGYTKIPTWIMQGYATLADEAVEQMREMGVTPTHVLLQAGVGAMAGGVLGYLVDVYSPQNLHSIIVEPDKADCIYRSGVKGDIVNVGGDMATIMAGLACGEPNPLGWEILRNCATQFISCQDSVAALGMRVLGNPYGNDPRIISGESGAVGLGVLAAVHYHPQRQSLMEKLALNKDAVVLVISTEGDTDVKHYREVVWEGKHAVAP
Protein: Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3) (Q2Y0W8)
Organism: Homo sapiens (Human)
Function: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons (By similarity). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:17715183}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Carbonic anhydrase 2
- Adhesion G-protein coupled receptor V1
- Pendrin
Sequence:
MPAAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEQEPHGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKAKEEEEAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALSMNSGNAKEKSLFN
Protein: Sliding clamp (DNA polymerase accessory protein Gp45) (DNA polymerase clamp) (Gene product 45) (gp45) (Sliding clamp Gp45) (P04525)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Sliding clamp that encircles the genomic DNA and links the DNA polymerase to the template to control the processivity of DNA synthesis. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Interaction with the sliding-clamp-loader opens the sliding clamp so that it can be loaded around the DNA template. During transcription, encircles the DNA and tethers host RNA polymerase (RNAP) to it.
Interaction partners:
Sequence:
MKLSKDTTALLKNFATINSGIMLKSGQFIMTRAVNGTTYAEANISDVIDFDVAIYDLNGFLGILSLVNDDAEISQSEDGNIKIADARSTIFWPAADPSTVVAPNKPIPFPVASAVTEIKAEDLQQLLRVSRGLQIDTIAITVKEGKIVINGFNKVEDSALTRVKYSLTLGDYDGENTFNFIINMANMKMQPGNYKLLLWAKGKQGAAKFEGEHANYVVALEADSTHDF
Protein: Probable WRKY transcription factor 25 (WRKY DNA-binding protein 25) (O22921)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Functions with WRKY33 as positive regulator of salt stress response and abscisic acid (ABA) signaling. Plays a partial role in heat stress tolerance. Functions with WRKY26 and WRKY33 as positive regulator of plant thermotolerance by partially participating in ethylene-response signal transduction pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:18839316}.
Interaction partners:
- Protein MKS1
- Probable WRKY transcription factor 33
- Mitogen-activated protein kinase 4
- Mitogen-activated protein kinase 3
- Zinc finger protein ZAT12
- Zinc finger protein ZAT7
- Sigma factor binding protein 1, chloroplastic
- Mitogen-activated protein kinase kinase 1
- Sigma factor binding protein 2, chloroplastic
- Mitogen-activated protein kinase kinase kinase 1
Sequence:
MSSTSFTDLLGSSGVDCYEDDEDLRVSGSSFGGYYPERTGSGLPKFKTAQPPPLPISQSSHNFTFSDYLDSPLLLSSSHSLISPTTGTFPLQGFNGTTNNHSDFPWQLQSQPSNASSALQETYGVQDHEKKQEMIPNEIATQNNNQSFGTERQIKIPAYMVSRNSNDGYGWRKYGQKQVKKSENPRSYFKCTYPDCVSKKIVETASDGQITEIIYKGGHNHPKPEFTKRPSQSSLPSSVNGRRLFNPASVVSEPHDQSENSSISFDYSDLEQKSFKSEYGEIDEEEEQPEMKRMKREGEDEGMSIEVSKGVKEPRVVVQTISDIDVLIDGFRWRKYGQKVVKGNTNPRSYYKCTFQGCGVKKQVERSAADERAVLTTYEGRHNHDIPTALRRS
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (O46122)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MCVNRETQSSSNNNSNNTTTATSTARNNNSHNGRCECDGDGDSVSHIQSEMKMRIKREAPCLLLFMPIQNTNNNNRIGANQKDYPNKRSRENLACDEVTSTTSSSTAMNGGGRTPALTRSCSSPAVYDIETHPASPVFPHLLLGNGRDADNPSSVGANCVLNVTCQSPNESHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARPIISPNLNFMGQLLELEQNLRKSGVLAPATPHLNSPSNPSSSSVGLSTQSSQLVEQPEEEEKREQRERGKSKSDSEAMDEDGFDYDDVDSGSGSLAGSNCSSRLTSPPITPDDEAPSTSAAASSVSELDSPSSTSSSSGICSLLQSTSSSVSPRAISKPNLLSPTRQLALFKRNSPAKLRLDLESSYAPASPIPNTMPWLSVPSTPVCEEAPDSRINHVASNLTRD
Protein: General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (DNA 3'-5' helicase/translocase XPB) (DNA repair helicase ptr8) (Poly(A)+ RNA transport protein 8) (RNA polymerase II transcription factor B subunit ercc3) (TFB subunit ercc3) (O13768)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ptr8, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ptr8 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription (By similarity). Plays a role in mRNA export.
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889}.
Interaction partners:
- General transcription and DNA repair factor IIH subunit tfb4
- General transcription and DNA repair factor IIH subunit tfb1
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH subunit tfb2
- RNA polymerase II transcription factor B subunit 3
- General transcription and DNA repair factor IIH subunit ssl1
- Transcription initiation factor IIE subunit alpha
- Transcription initiation factor IIE subunit beta
- Cyclin mcs2
- Uncharacterized protein C1494.09c
Sequence:
MSLKRKNNAREGTPDEDLEEYSDYSDVDNYGEEDDDSYKPAPRIRINNNKTKAQTTTNSNEARQSGISAMFGQNDFSNLLGLKLDHTARPLWINPIDGRIILEAFSPLAEQAIDFLVTISEPVSRPAFIHEYRITAYSLYAAVSVGLKTEDIIAVLDRLSKTPIPPSIVDFIRACTVSYGKVKLVLKKNRYFIESGDASVLRLLLRDPVIGPLRIDYSTQSSKQKSSKPSNEDNVEDKKDITNDSSKETAEKSSSDELFSAVVGLQEEEDDEDAVHLFEIKHSSVETIKKRCAEIDYPLLEEYDFRNDNINPDLPIDLKPSTQIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIVLCTSSVSVMQWRQQFLQWSNIKPDHIAVFTADHKERFHSEAGVVVSTYSMVANTRNRSYDSQKMMDFLTGREWGFILLDEVHVVPAAMFRRVVTTIAAHTKLGLTATLVREDDKIDDLNFLIGPKMYEANWMDLAQKGHIAKVQCAEVWCAMTTEFYNEYLRENSRKRMLLYIMNPKKFQACQFLIDYHEKRGDKIIVFSDNVYALRAYAIKLGKYFIYGGTPQQERMRILENFQYNELVNTIFLSKVGDTSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYSSKRQAFLIDQGYAFKVITNLKGMENLPNLAYASKAERLELLQEVLLQNEEAADLDDGEDTSFGSRSLSRAPAKAKRSSGSLSTLAGADNMAYVEYNKSANKQLKKDSKEHHALFRKHLYTKRR
Protein: Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86) (Q96JA3)
Organism: Homo sapiens (Human)
Function: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15107860}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:15107860}. Note=Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites. {ECO:0000269|PubMed:15107860}.
Interaction partners:
- ADP-ribosylation factor 1
- Bile salt-activated lipase
- Phosphatidylinositol 4-kinase beta
- Pleckstrin-2
Sequence:
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV
Protein: Flotillin-1 (Q767L6)
Organism: Sus scrofa (Pig)
Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O75955}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75955}. Endosome {ECO:0000250|UniProtKB:O75955}. Membrane, caveola {ECO:0000250|UniProtKB:O08917}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08917}. Melanosome {ECO:0000250|UniProtKB:O75955}. Membrane raft {ECO:0000250|UniProtKB:O75955}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Membrane-associated protein of caveola. {ECO:0000250|UniProtKB:O08917, ECO:0000250|UniProtKB:O75955}.
Interaction partners:
- Tetraspanin
- CD81 molecule
- Flotillin
- CD9 antigen
- Caveolin-1
- UEV domain-containing protein
- Stomatin
- Leucine-rich repeat and fibronectin type-III domain-containing protein 3
Sequence:
MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAAAEKSQLIMQAEAEAESVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSAKKITLVSSGSGTMGAAKVTGEVLDILSRLPESVERLTGVSISQVNHKPLRTA
Protein: LIM/homeobox protein Lhx8 (LIM homeobox protein 8) (Q68G74)
Organism: Homo sapiens (Human)
Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Factor in the germline alpha
- Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1
- Homeobox protein NOBOX
- Homeobox protein GBX-1
- Homeobox protein MSX-1
- Y-box-binding protein 2
- Paired box protein Pax-9
- LIM domain-binding protein 1
- Homeobox protein DLX-2
Sequence:
MQILSRCQGLMSEECGRTTALAAGRTRKGAGEEGLVSPEGAGDEDSCSSSAPLSPSSSPRSMASGSGCPPGKCVCNSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSTPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHSPTTLGLQPLLPHSMTQLPISHT
Protein: Kinesin-like protein Klp59C (Kinesin-like protein at cytological position 59C) (Q9W1U4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required during anaphase to drive sister chromatid separation to actively depolymerize kinetochore microtubules at their kinetochore-associated plus ends, thereby contributing to chromatid mobility through a 'Pac-man' mechanism.
Subcellular location: Chromosome, centromere {ECO:0000269|PubMed:14681690}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14681690}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:14681690}. Note=Primarily restricted to centromeric regions of chromosomes during both metaphase and anaphase. Not localized on spindle poles throughout mitosis. Concentrated on the plus ends of kinetochore microtubules embedded in the kinetochore.
Interaction partners:
- FI06030p
- Kinesin-like protein Klp61F
- non-specific serine/threonine protein kinase
- RT07324p
- FI21273p1
- Kinesin-like protein at 67A, isoform A
- Kinesin-like protein
- CENP-meta, isoform C
- Kinesin-like protein subito
- Aurora kinase B
Sequence:
MDKLSIEQKIFIRRSDGRVHLAEIIKLEGGDSKLITVEWPEGHTVRGKELPLELVVLMNPHIFDSPRCSGGNAASANQTASISPRSMKQRIATGSLSPVLATAPPRQQTAPPVREDEVVHQAERMRKERERRREAQARTRLDREQGKNEDPGNPNWEVARMIRLQREQMESQRVRSGTTNERINCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAMAAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHGKFSLIDLAGNERGADNSSADRQTRLEGSEINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKELSVESIPSKRMPDANLGSTSMSDIVCQSSTQRLFPCASSTSMPGGGNQAQQHTNTANDLNRSQKPTSKPTYPTSGQQLVQRKGSSQREASMMLTKSLAQFRGRNFP
Protein: Ceramide kinase-like (Zgc:162213 protein) (A4QNW6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Protein FAM161A
- Protein eyes shut homolog.
- Protein eyes shut homolog
Sequence:
MLESPCKSISVLNAWSESQEELRETQPVSPHGTEKRVKTKKKKRKQKQSQKRSVSAPQLCPEEDYKERVETKYRPDEPIVRGIFQIEKKSHDVVLTTTRVTWTPIQPETPTADRDLKKQEEYVDLKDVFAVKVKRRRSAGQQSGGTLLGITLFQCKKKGLKLKDHAIHLNNLSVDHCEIWFKTLKELLNGFKNRPKSLKVFVNPISHKKEAYQIYLDEVAPLFKLADIQVDVTITERKGHALSILKDCSLEDYDGVVCVGGDGSVSEVAHGLLLRAQMDAGRDTDSIFTPVQAALPLGVIPAGSTDVVACSVHGIRRAATAALHIIMGHHQPVDVCSFSCMGRLLRFGFSAMFGFGGRTLALAERHRWMPPSQRREFALIKTLAKLKPEDCELSFLTAKGAEDQKKAELNGDGGDICEGDWQSRKGLFLNISIMAIPCLCSMAPRGLAPNTRLNNGSMALISVGNTSRSEFIKHLKRYNSTNNQFGFSFIETHSVKAVRLRPSSQSSWTDDVSEENEESDSKNTPIISSEGTYPWNIDGDLLDVPSELLIRVHPQLLTLFGSDVEEAEETPVKCSCI