wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein Rv2558 (P9WLA3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv2557
- Protein USFY
- Tetracyclin repressor-like C-terminal domain-containing protein
- PE family protein
Sequence:
MPGSAGWRKVFGGTGGATGALPRHGRGSIVYARSTTIEAQPLSVDIGIAHVRDVVMPALQEIDGCVGVSLLVDRQSGRCIATSAWETLEAMRASVERVAPIRDRAALMFAGSARVEEWDIALLHRDHPSHEGACVRATWLKVVPDQLGRSLEFYRTSVLPELESLDGFCSASLMVDHPACRRAVSCSTFDSMDAMARNRDRASELRSRRVRELGAEVLDVAEFELAIAHLRVPELV
Protein: Capsid maturation protease (EC 3.4.21.-) (Gp175) (Prohead protease) (Q8SCY7)
Organism: Pseudomonas phage phiKZ
Subcellular location: Virion {ECO:0000269|PubMed:22429790}. Note=Low-copy capsid protein. {ECO:0000269|PubMed:22429790}.
Interaction partners:
Sequence:
MQPYSNFSGLQQRTNNQVVIGSDMLAGTNKKGVLVPDADGYYLTPLGAYGTRNSAGMFYEMASGVSMFNPDSPLMRRVKKGVLFMEYKHPEPYRKDGTRMNEHEYLMRIRQIDDDRVCAHIKELILVDSTDEKGLPIKLVLGKCKPYGPFGKYFEASITNPSQNTYCSVRSITQDDPMRGIKYTREISTWDMVGEGGIYGANKWNSPALENYEDQLMVITPDTLYQVQRERERQINMGFECSDITNVTDLAKSLGWDISPVKHRRPGFMR
Protein: Bile acid receptor (Nuclear receptor subfamily 1, group H, member 4) (Q6DGW7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MNDWVGHDVNVVGPLQIPPNDAFPLSESSHFFDILAEQNSPLLQDQEVMPFTSYPSMQYTSVEPSMSSPSYYSSQHCYSQYGAEEWYSPSAMFEMRKGPLDGGFDNELDESCPVIPTVCKRSRHAGHSGKSKGEELCVVCGDKASGYHYNALTCEGCKVFFRRSITKNAVYKCKSGGNCEMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKNTKASSDGSIGDDVVDSRDPKQVVSTTKPSKENIELSQDQQALINYIVDAHNKHRIPQDMAKKLLQEQFNAEENFLLLTEMATSHVQVLVEFTKNIPGFQSLDHEDQIALLKGSAVEAMFLRSAQVFSKKLPNGHTEVLEDRIRRSGISEEFITPMFNFYKSIGELQMMQEEHALLTAITILSPDRPYVKDQQAVERLQEPMLEVLRKICKLQHPQEPQHFARLLGRLTELRTLNHHHAEMLESWRMSDHKFNPLLCEIWDVQ
Protein: At1g72940/F3N23_14 (Similar to NL27) (Toll-Interleukin-Resistance (TIR) domain-containing protein) (Q9SSN2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable disease resistance protein At5g04720
- Lysophospholipid acyltransferase LPEAT2
- Serine/threonine-protein phosphatase PP2A-3 catalytic subunit
- At1g72880
Sequence:
MTSPTATKYDVFLSFRGVDTRRNFISFLYKEFVRRKIRTFKDDKELENGRRISPELKRAIEESKFAVVVVSVNYAASPWCLDELVKIMDFENKGSITVMPIFYGVDPCHLRRQIGDVAEQFKKHEAREEDHEKVASWRRALTSLASISGDCSSKCEDEAKLVDEIADKISKNLMTVTTISNGKNLVGIDTHMKALNKKLDLNSNKSLRVVGIWARGYNGRSALAKYVYQDICHHFDSHCFLGSVKRISQGRHLSHLHEEFLIRIQGSKHNLKDQKVLLVADDVYKLEQLDALAEDFNGFGPGSVVIITTQDKHLFVSAGIKLVYEVELLKFQKVCELFRQFAFKKRDISAAVKLVYYRATNWLGCLSGRSG
Protein: Vang-like protein (Q8MRA6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MENESVKSEHSGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRERDRSRHSHRSTHSSKSAKGFQRGDMAPYQTSVNMTGDGSHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSISMEDINNMWHRESDKGFSLACRRYVESSFYFLLGCGAFFSQVAMVVMPYVGFFPSAFDHPEITQTVRTQLLACSEQCKGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLFYIVQVTNGAKIVVETGGDAVDYKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRSPDGVSRSYMLGQLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEVDGVSNSQQQSQSRAVLAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNEPAPALPLDPQEAASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTESPVMQSEKERRWVQSWSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSNKFVLKLNSETSV
Protein: H2-Q1 protein (Q66JR0)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MALGRLLLLLAAALTLTKTGAGSHSLRYFETSVSQPGFGKPRFISVGYVDDTQFVRFDSDAKNPRYELRAPWMEQEGPEYWERNTRRVKGSEKRFQESLSTLLSYYNQSKGGIHTFQKLSGCDLGSDGRLQSGYLQFAYDGLDYIALNEDLETWTAADVAAQETRHKWEQAGAAEKHRTYLEGKCLMWLHRYLELRKEMLLRTDPPKAHVTHHPRSQGDVTLRCWALGFYPADITLTWQLNGEELTQHMELVETRPAGDGTFQKWASVVVPLGKEQNYTCHVYHEGLPEPLTLRWEPPPYTVSNMVIIAVLVVLGAVIVIGAVVIIGVMVSFVMKRRRNKA
Protein: Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) (Q71RI9)
Organism: Mus musculus (Mouse)
Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).
Interaction partners:
- Kynurenine 3-monooxygenase
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
- Kynureninase
- Kynurenine formamidase
- Aspartate aminotransferase, mitochondrial
- Cystathionine gamma-lyase
- Aspartate aminotransferase, cytoplasmic
- Cystathionine beta-synthase
- Adenosylhomocysteinase
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
Sequence:
MLLAQRRLISLGCRSKPIKTIYSSSKVLGLCTSAKMALKFKNAKRIEGLDSNVWVEFTKLAADPSVVNLGQGFPDISPPSYVKEELSKAAFIDNMNQYTRGFGHPALVKALSCLYGKIYQRQIDPNEEILVAVGAYGSLFNSIQGLVDPGDEVIIMVPFYDCYEPMVRMAGAVPVFIPLRSKPTDGMKWTSSDWTFDPRELESKFSSKTKAIILNTPHNPLGKVYTRQELQVIADLCVKHDTLCISDEVYEWLVYTGHTHVKIATLPGMWERTITIGSAGKTFSVTGWKLGWSIGPAHLIKHLQTVQQNSFYTCATPLQAALAEAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLNSVGLKPIVPDGGYFIIADVSSLGADLSDMNSDEPYDYKFVKWMTKHKKLTAIPVSAFCDSKSKPHFEKLVRFCFIKKDSTLDAAEEIFRAWNSQKS
Protein: Plexin A, isoform A (Q9V491)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Semaphorin-1A
- MIP07328p
- Semaphorin-2A
- [F-actin]-monooxygenase Mical
- Semaphorin 5c
- Semaphorin-2A
- Tyrosine-protein kinase-like otk
- Plexin-B
- Ephrin
- Receptor-type guanylate cyclase Gyc76C
Sequence:
MNFVLSVLLIAILKDKYDYWLPSRTGCQTLAANIWSDKTTAQNEPINLTNANAPIKNAKNLNSTITNVAAFDTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVECSILDCPLNAVRSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSIIEHEVPDAVVANDANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSLEKTKMFQIASSAVTTGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGNTPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDFISPSMPCVLTKLQTIGEDFCGLDVNSPLGGETPITSVPVAMFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIIDHLPQLKENLICAFTTEDKALFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRVTSLNAQLLGDTIYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQIGDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCRVQSDTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEERVKYFKSEYLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHEDHIVLQWERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQVHNIMSSE
Protein: Amino acid transporter (F1MUJ6)
Organism: Bos taurus (Bovine)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}.
Interaction partners:
Sequence:
MPKQVEVRMHDSHLSAEEPKPRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSDEDGNATNAVLSLLNETVTEVPEETQVVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFLVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDLKNHRESNSNQCVYAAHNSVIVDECKLSDRVQLCGDREVRQLTLLVLDQSAGLTPMHRGGSQSYRDEFAGFTQSIGVTFTPAFETLSGLFCSTVLKTELGTSVLSTSPLPFRLF
Protein: Mitochondrial distribution and morphology protein 10 (Mitochondrial inheritance component mdm10) (O13814)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the receptor tom22 and small TOM proteins. Can associate with the SAM(core) complex as well as the mdm12-mmm1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the tom40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
Subcellular location: Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03102}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03102}. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids. {ECO:0000255|HAMAP-Rule:MF_03102}.
Interaction partners:
- Mitochondrial distribution and morphology protein 34
- Mitochondrial distribution and morphology protein 12
- Maintenance of mitochondrial morphology protein 1
- SAM50-like protein SPAC17C9.06
- Probable mitochondrial import receptor subunit tom40
- Mitochondrial Rho GTPase 1
- Metaxin-like protein C409.19c
- Mitochondrial import receptor subunit tom7
- Dynamin-related protein dnm1
- Metaxin-1
Sequence:
MMSFNDYIFYEYLKKTNWNIHNLYCNLTQTADNILNFEIPSGVSCQLSSLTSSNFASGCKISAMPILNGSMSYVYTNVNLENLNRNITYNLQHFYEGYKHVDVPFVHYVNEFQDKKLPLRPTLLYGRMHLPSQHLDAIFATRLSPWLLFFIQGVNEIEDGVGDNLCFNWQYDTGKRCLEFVYESSGAMLGVRGLWNLNYRELNTKINMENKAPSNMRWSLGFETYYGVLTKCAGASLGMRLHSGPSHPYAPFILTCTLNPIVGHITSTFSTAEPRTKAFSAQYDFNIYSYESQLKLGIELWRSKQEMSQSTNDPTANSMSSLLKGTCSTSGDVSISWQARIRNFLLTIGTEAQLTKIDPLFFGVHFEYSK
Protein: RE73180p (Suppressor of variegation 2-10, isoform D) (Q8IGK3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRKTRSQTARTQAENAATSSSPGHQSTSSAPIAVNPFDSTKYKECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLELLAPKVQEVYAQSVQEQNATLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSETVDLTLSDSDDDMPLAKRRPPAKQAVASSTSNGSGGGQRAYTPAQQPQQSGGNVFKKPQKAEELYKRVHLGVWLRPRKPKPESSRRPNVG
Protein: Retinol dehydrogenase 5 (EC 1.1.1.105) (Q4V8Y1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MYEFLSNSCPSTYALGTFAILWVLVWFYRDNLKITRVSEKHVFVTGCDSGFGNLLCKRLDKRGFRVLAGCLTEKGADDLKRAAGPFLKTCILDVTSSASIQKAMEWTKNEVGDKGLWGLVNNAGRSLPMGPSEWMKIEDFESTLKVNMTGVIETTMTFLPLVKKARGRIVNVASVLGRVAANGGGYCISKFAVESFSDCLRRDIQGFGVNVCIIEPGFFKTQVTSLEPIERELHRLWNQLTPEVKESYGDKYLDKYIWIQRLIMNAICDSDLSKVTNCMEHALLAVHPRTRYSAGWDAKFLWIPLSYMPACFVDIALKLVMPKPAKGV
Protein: Leucine-rich repeat protein (LRRP), putative (Q382Z5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFISFYYFKRVFLVCQVKMREKEAHKGRNGVLNVSNLPGEHTSLDSIGQLHDALTGGNCKRYVSITAQHDSLLSLTLSPSLASAVQHITSLTASHNRLSTLQGIEAFVCLEFLDLSHNALRILDAHSTTLLRKLRCLKRCNFSYNEICMADFDTTFRCGISHNESGANKEGGIASAATPMASAGSVGPAVPGFLEELTHLDLSHNQLIEVPDLRCIPVLEELNLSYNRIDLIADLDNRLPLLRLCSFSISHNSLAVLPSLLPLTVLAGTLCVLNVAGNPCVQDFESTDPAMGGIRAWLLWLLPYLELLDEVPLTTEERQIACKLFRRNNKLSYELMDVMNTNNGTQLVSYLRKFTQRTTSRSLVGARESVREKSPPSPNPAVGAVNGGVINNVGGIRFATGAVFPSASPSPAADGTVRRTSSKPQPIELVVQMLQWKVRQLSNVMEVLWQESMARRVFAVRVLQRHVRGFLARRQLPEVVHRTCTRIRTNMLASGQRPYFPDQRRSAKADTTLSVVRSLGCESISTAESEHSVHTEIMQRIDNFDHLFRQMEEELHKFRIFWARTREKSVVVVQKYYRGYLDRKRWRNLKESYDVFIDSLRPYVVELQRVSRGYVSRARLAKDSRQLREMSRLRGEVAGLRAAVDEMRAILQQYAQKQRRGDPESPVVESPTKRAVAHSIPLAKNSAANTGTTLTAAATAAAAQASAVARISPEL
Protein: Probable (S)-ureidoglycine aminohydrolase (OsUGLYAH) (EC 3.5.3.26) (Q7F1K9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in the catabolism of purine nucleotides. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8GXV5}.
Interaction partners:
- Ureidoglycolate hydrolase
- Probable allantoate deiminase
- alanine--glyoxylate transaminase
- Probable allantoinase
- N-acyl-aliphatic-L-amino acid amidohydrolase
- Os08g0511900 protein
- Acetylornithine deacetylase
- Os03g0128800 protein
- Os05g0392700 protein
- Os01g0513200 protein
Sequence:
MMLPRLLLLVVASALPLASVAAGAVGVGEGFCSAEPSAASGGCSGVRPPLYWKATNPTLAPAHLQDLPGFTRSVYKRDHALITPESHVFSPLPDWINTLGAYLISPAIGAHFTMYLAKMHDGSKSALPPKGVERLIFVLQGSILLSEESGNTHTLLVDSYAYLPANMKHSVISDEVTTLVIFERRYTTIEGYHPDLIVGSTDKQPLLETPGEVFELRKLLPTSLPYDFNIHIMDFQPGEYLNVKEVHYNQHGLLLLEGQGIYRLGDSWYPVQSGDTIWMAPFVPQWYAALGKTKTRYLLYKDVNRDPLI
Protein: cDNA FLJ61541, highly similar to Homo sapiens PDZ and LIM domain 5 (PDLIM5), transcript variant 2, mRNA (B7Z8X5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKPTVTSVCSETSQELAEGQRRGSQGDSKQQNGKIPPKRPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTTAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPL
Protein: Large ribosomal subunit protein uL23 (60S ribosomal protein L25) (RP16L) (YL25) (YP42') (P04456)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL23 is a major component of the universal docking site for these factors at the polypeptide exit tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein uL6A
- Small ribosomal subunit protein eS1A
- Small ribosomal subunit protein eS10A
- Nucleolar GTP-binding protein 2
- Large ribosomal subunit protein eL24B
- Large ribosomal subunit protein eL19A
- Large ribosomal subunit protein uL6B
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein eL27B
Sequence:
MAPSAKATAAKKAVVKGTNGKKALKVRTSATFRLPKTLKLARAPKYASKAVPHYNRLDSYKVIEQPITSETAMKKVEDGNILVFQVSMKANKYQIKKAVKELYEVDVLKVNTLVRPNGTKKAYVRLTADYDALDIANRIGYI
Protein: Biogenesis of lysosome-related organelles complex 1 subunit SNN1 (BLOC-1 subunit SNN1) (SNAPIN-like protein 1) (P48232)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.
Subcellular location: Endosome {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit BLI1
- Biogenesis of lysosome-related organelles complex 1 subunit VAB2
- Biogenesis of lysosome-related organelles complex 1 subunit CNL1
- Biogenesis of lysosome-related organelles complex 1 subunit KXD1
- Biogenesis of lysosome-related organelles complex 1 subunit BLS1
Sequence:
MAGDSISADGTGVHPVELSVYSVLSTDLDGLYQSINELRESQALLILMLRKVRDKLRREGQVLYDPEPFKPTMDKLADLSARVRILSQRYEELQGNARALNN
Protein: Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Protein-tyrosine kinase Mpk-9) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Q9WUT3)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- GTPase KRas
- GTPase HRas
- Tuberin
- Mitogen-activated protein kinase 7
- Hamartin
- GTPase NRas
- TBC1 domain family member 7
- Mitotic checkpoint serine/threonine-protein kinase BUB1
Sequence:
MELSMKKFTVRRFFSVYLRKKSRSKSSSLSRLEEEGIVKEIDISNHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFFVTIDWNKLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLVQEPSQQDVPKAPIHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPWIVNREYLSQNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSSLAQRRGMKRLTSTRL
Protein: Thymine DNA glycosylase (G8JL98)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGECYSLQQAQAFYTFPFQQLMAEAPNMAVVNEQQMPEEVPAPAPAQEPVQEAPKGRKRKPRTTEPKQPVEPKKPVESKKSGKSAKSKEKQEKITDTFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNMDVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCSSEPCGFSSNGLIESVELRGESAFSGIPNGQWMTQSFTDQIPSFSNHCGTQEQEEESHA
Protein: FERM, ARHGEF and pleckstrin domain-containing protein 1 (FERM, RhoGEF and pleckstrin domain-containing protein 1) (E9QIC8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
Interaction partners:
Sequence:
MVEPEERPSVAGQRLGAPESLGISTLEPGQRPPTMPPGRQISIRVQMLDDTQEVFEVSQRAPGKALFDLVCSHLNLVEGDYFGLEFQDQRKMIVWLDLLKPILKQIRRPKNIILRFVVKFFPPDHTQLLEELTRYLFALQIKHDLACGRLTCNESSAALLVAHIVQSEIGDFDEVQCKQHLLNNKYIPEQDTLMDKIIGYHRKHVGQTPAESDYQLLEIARRLEMYGVRLHPAKDREGTRLSLAVAHSGVLVFQGHTKINAFNWSKVRKLSFKRKRFLIKLRPDLNSNCQDTLEFMMGSRDCCKVFWKICVEYHAFFRLFEEPKPKPKPVLFTRGSSFRFSGRTQRQVIDYVKDTEFKKVPFERKHSKIQSNSNLSPFPSRQSAEGQGERNASASGHQADSPLGRTQVTVENPALQRYTGSLNSQTNGCRNGTSDEADARLKPSPSKQQAEHLSTGPVSRSPQHSESPSAGQMMVNGQKQSLSVGQSPDGRQPSPLTSPLLYDAGFIRADDEDERFPTDKAYFIAKELLTTERTYLKDLEVITVSFQKAVLKDEAMPDSLRNLIFANFEPVYKFHETFLKDVEQRLAQWEGRSNAHIKGDYQRVGDVMLKNIQGLKLLSSHLQKHSESLLELEQSCRSSRRLEVLCRDFELQKVCYLPLNIFFLRPLHRLLHYKQILERLCKHYPPTHDDFRDSRAALADVSELVLQLHTTLMKMENFQKLLELKKDLVGIDSLAAPGREFIRLGCLSKLSGKGLQQRMFFLFSDVVMYTSRGLTASNQFKVHGQLPLYGMTIRESEDEWGVPYSFTLFGQRQSVVVAASSASEMEKWIEDIRMAIELADKSNGPTTEILSSSFSDSKSPEDCSADQESEDDLSSSRSSLERQTPHRGNTTVHVCWHRSTSVSMVDFSVALENQLSGNLLRKFKNSNGWQKLWVVFTNFSLFFYKTHQDEYPLASLPLLGYSITIPSESENIHKDYVFKLHFKSHVYYFRSESEYTFERWMEVIRSATCSSSVLRSSSRKDPLVY
Protein: Transcription factor efl-3 (E2F-like family member 3) (Q20619)
Organism: Caenorhabditis elegans
Function: Probable transcription factor which represses gene expression in a subset of ventral nerve cord neurons. Involved in regulating programmed cell death and determining cell fate during development, acting in a partially redundant manner with lin-39 to repress the BH3 domain-encoding gene egl-1 in the VA and VB motor neurons.
Subcellular location: Nucleus {ECO:0000255|RuleBase:RU003796}.
Interaction partners:
- Transcription factor dpl-1
- Retinoblastoma-like protein homolog lin-35
- Serpentine Receptor, class T
Sequence:
MTTIFGSSNAMFLNIEANKENIPPGTEFKKESFVLPEPRVNRTTDPDHENLLPSPVPRPSPAMSQLSDASFLSQDGGAVNTSADEADDDLEVTSRKEKSLGLLCQRFLIAINEETVGSSTREVHLETVARKMNVEKRRIYDIVNVMEALDAMQKTNKSYYQWQGLESLPKLMFDLQNEAVEEGLPERVLRVEQAMCSFTELSSPRGKQGFKDIVGSFVSCTSTPTTPSTSFDSVTVKMEPAGLLEKRSRVDTRDRQGRNSLAQLCRRFLMVLLSNPKNIRKVSLDVASTVLIKDPETEGFEPPSRSRCRRLYDIANVLVALGLIKKVHYLFGTKKIPLFVYCGPEPDQTGSFDVFQSVERLLSSSQNVPQTPIIKAQTDKIVQQIAGFGKRTLSEQNLTKPSGNTPKIAKIKSAAVRSSPMYMENNLFMFAEVVTAEAAAEKMRYDAFAQLSRTILGSVASINSLNAPLTSSQHPMTSRLPPLPMAPLQLPKLPEIPKPQAQKQFTFPATSRPRFNFPDYTPVQSTIRPLVSQMTFPQESSQLHNLDVKPKHLMSNILGESKKFKNNQNTFEHTTSSAFQVVKKGETRPKKVFGEIQNLQ
Protein: Uncharacterized protein (B0G115)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MLLYGNKELFRYKVTRNEKDSLYFQDGDINVILQKCKDQDKDYKLFQDLFINYFHYFFPNTIETNNLLNLIIKHDNLIAFKVFLTIINPIITKKTIIDAIKFGAVDIVTHLSNNNNNNNNNNNNNNNNNNNNNNYNNSNNNNYMYLSEDDIVKLLEFIINKNNCFGSEKENDCFLIFSNDSINDFGFKQNNDIDFSNLNIIRFFKRSIECFKKLNIKIPNQLLNPIKYYIFSGFNENGSQRTSLLDITLEFLIELYEAVHYLSPLFLESPADQTYKSCYQSTNMVLSNEEFQSIKNSFTKIELKSLLKDLDYSDKIEILFRNVSMVSNINPNDYNLKYYFKVEILRNLEFIINYGDSSFLKSFSQQLINDIENVNNNNKEEFIRSIFFLLLENFECLKMIVNQCKETDRGGEFLKSNIHIFKRVNSIETFNILYGCEILKSQFKLDDLFYGFYDINDNDLNEIDESDVRDQSILLSILNHFKITYPEDYNRESIKLDFIENKRLFSNDFICNNYQDFKENILKCNLPIENQQIINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGYWSTYFREISEIENVNIEISLHLNLNQFISILELTPAQQQYSCLSNPEILAWIFENRDYDLKSGRCIQPLNKTLFSYLFHSNQLSKALNDIDYFNNPGERDHRNYQDLYDPDHHLLERIGEEEFGLEKVTNAMSESNKNFTKEEIQDFNTIIKLSLLMNVDINNFINTIIKFNFLDDLEILYHFLNSIGNSKKFGKQLSQLKDIILSCIANYNRINCLKLLWRLDQYNKSFFDDRLLTSIYKEFRKSRSMVIHEIENILRNHFKKKIQDEEEVNQESEDDENEGDNEENKDYEENENEDEENEDEEDEE