wanglab/gogpt-training-data huggingface dataset:
Protein: Glycoprotease family protein, putative (Q72DR5)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- tRNA N6-adenosine threonylcarbamoyltransferase
- tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
- Bifunctional ligase/repressor BirA
- Zinc metalloprotease
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase
- Isoprenyl transferase
- Phosphatidate cytidylyltransferase
- Aromatic amino acid decarboxylase, putative
Sequence:
MSGLTLIMNAAEGLLQLAVLRDGQRLFAQAWDAPSRGTELLTPALREGFARMHLSIGDIDRIACVNGPGSFTGLRLVLSTAAALARSTGAQTAGIDYMHALADRACQLPGMLVWAVTHARRGLVHMQGFTTRGCDSLPVPVARVEALNLQGAVERILRFGGAPVVLGSGLSRNRAFFAEHLPAALLLPADHDQPTIQSLIRLTAAATWSHDDVQPFYLRPCDAEENLADLVTRRGIDPDAARNTLARLTTLSADESACRQF
Protein: Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) (Q99KY4)
Organism: Mus musculus (Mouse)
Function: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O14976}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O14976}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O14976}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:O14976}. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions. Recruitment to clathrin-coated vesicles depends on temporal variations in phosphoinositide composition of clathrin-coated vesicles. {ECO:0000250|UniProtKB:O14976}.
Interaction partners:
- Clathrin heavy chain 1
- Clathrin heavy chain linker domain-containing protein 1
- Clathrin light chain A
- Huntingtin-interacting protein 1-related protein
- BAG family molecular chaperone regulator 5
- Ras-related protein Rab-7L1
- Clathrin light chain B
- Dynamin-2
- Phosphatidylinositol-binding clathrin assembly protein
- Heat shock cognate 71 kDa protein
Sequence:
MSLLQSALDFLAGPGSLGGAAGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKRVECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPVNDTRYTVFHDLIRAMLKVNPVERLSIAEVVRQLQEIAAARNVNPKAPITELLEQNGGYGNSGPSRAQPPCGGTVNSSGVLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRMFLDAKHPGHYAVYNLSPRIYRASKFHNRVTECGWAVRRAPHLHSLYTLCRSMHAWLREDHRNVCVVHCMDGRAASAVAVCAFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYVCDMVAEEPITPHSKPMLVKSVVMTPVPLFSKQRNGCRPFCEVYVGEERVTTTSQEYDRMKEFKIEDGKAVIPLGVTVQGDVLIIIYHARATLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAPPWENTSLRGLNPKILFSNREEQQDILSKFGKPELPRQPGSTAQYDAEAGSPEAEITESDSPQSSSTDTNHFLHTLDWQEEKEPETGLDNTSPKESQSVLIADGDGSEVSDEEEASFPSEERKPGAGEDTPRLAAGTKQQDLIFDVGMLAAPQEPVQPEEGVDLLGLHSEGDLRPAAPLQACGVPSSNTDLLSCLLEPSDAAQVGPPGDLLGGEAPLLLASPVSPLGLQNNLQGKVPDTVDPFDQFLLSSNSDTQPCSKPDLFGEFLNSDSVASSTAFPSTHSAPPPSCSTAFLHLGDLPAEPSKVIASSSHPDLLGGWDTWADTATPGPASIPVPEGTLFSSAGHPAPPGPNPSQTKSQNLDPFADLSDLSSSLQGLPAGLPAGGFVGAPAPTQKSNSPWQANRPTAPGTSWTPQAKPAPRASEQLRSHFSVIGAREERGVRVPSFAQKPKVSENDFEDLLPNQGFSKSDKKGPKTMAEMRKQELARDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVSMADLVTPEQVKKQYRRAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFENQGSRPLF
Protein: Cyclin-dependent protein kinase-activating kinase (A0A1D8PH53)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Pho81p
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin CLB2
- Nucleoporin NSP1
- Cell division control protein
- Cyclin-dependent kinases regulatory subunit
- Mitosis inhibitor protein kinase SWE1
- Glycerophosphocholine phosphodiesterase GDE1
- [RNA-polymerase]-subunit kinase
- Origin recognition complex subunit 2
Sequence:
MKLSDYYIDKELIYNSAISDIYTAIDKFNNLPVCLKIVDEDFSLPPHSIHREVLILKTLKPHPNIIEYFNDLKICDDIILVTKLYRYDLSQLIEITKYCKRTTRFIYGINGNLVSNQYTLANEIEEKDIKLWLKSMSSGLEFIHSQGIIHRDIKPSNIFFARDDITQPIIGDFDICYDLKSPPKDEPPMAKYIDVSTGIYKAPELILGITNYEYEIDIWSLGIILTGLYSENFQSVLVKDDKELTNDSHVSDLYLLNQIFENFGTPNLTDFEDELFCDEYNNENLHFKKFNLQKYPRKDWDIILPRCNDDFMKEIFTKMIRYDRSKRITSKEILQLMLD
Protein: Cytochrome P450 2A1 (EC 1.14.14.1) (CYPIIA1) (Cytochrome P450-UT-F) (Steroid hormones 7-alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase) (P11711)
Organism: Rattus norvegicus (Rat)
Function: Highly active in the 7-alpha-hydroxylation of testosterone, progesterone and androstenedione.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
Sequence:
MLDTGLLLVVILASLSVMLLVSLWQQKIRGRLPPGPTPLPFIGNYLQLNTKDVYSSITQLSERYGPVFTIHLGPRRVVVLYGYDAVKEALVDQAEEFSGRGEQATYNTLFKGYGVAFSSGERAKQLRRLSIATLRDFGVGKRGVEERILEEAGYLIKMLQGTCGAPIDPTIYLSKTVSNVISSIVFGERFDYEDTEFLSLLQMMGQMNRFAASPTGQLYDMFHSVMKYLPGPQQQIIKVTQKLEDFMIEKVRQNHSTLDPNSPRNFIDSFLIRMQEEKNGNSEFHMKNLVMTTLSLFFAGSETVSSTLRYGFLLLMKHPDVEAKVHEEIEQVIGRNRQPQYEDHMKMPYTQAVINEIQRFSNLAPLGIPRRIIKNTTFRGFFLPKGTDVFPILGSLMTDPKFFPSPKDFDPQNFLDDKGQLKKNAAFLPFSTGKRFCLGDGLAKMELFLLLTTILQNFRFKFPMKLEDINESPKPLGFTRIIPKYTMSFMPI
Protein: GAIP c-terminus interacting protein 2 (GIPC PDZ domain-containing family, member 2) (Gipc2 protein) (PDZ domain-containing protein GIPC2) (Q7ZV93)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- HESX homeobox 1.
- Neuropilin-1a
Sequence:
MPLGLRKKKNKSRESSNLVENEEIGGHAVVGKSAVNGGGLPPPPASLRPKLVFHTQLAHGSPTGRIEGFTNVKELYNKIAEAFNLSPDEILFCTLNTHKIDMEKLLGGQIGLEDFIFAHIKGIKKEMDVYKSEEALGLTITDNGAGYAFIKRIKEGSVVDGVKVICVGDHIECINGKNIVGMRHYEVARMLKELPKDQTFTLKLVEPMKAFEMLEPRSRGAGGKTSGEGKIGTGRETLRLRSKGPATVEEMPTEFEEKAVKKVDDLLESYMGIRDTELAATMVEVGRDKKNPDEFAMALDQALGDFAFPDEFVFDVWGAIGDAKQGRF
Protein: Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) (Q9NRY7)
Organism: Homo sapiens (Human)
Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Subcellular location: Membrane {ECO:0000250|UniProtKB:O15162}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O15162}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:24648509}.
Interaction partners:
Sequence:
MRSWNSLFCLNSSRPPGHIVYPKHQAGHTGKQADHLGSQAFYPGRQHDYLVPPAGTAGIPVQNQPGRPEGVPWMPAPPPPLNCPPGLEYLSQIDMILIHQQIELLEVLFSFESSNMYEIKNSFGQRIYFAAEDTNFCIRNCCGRSRPFTLRITDNVGREVITLERPLRCNCCCCPCCLQEIEIQAPPGVPVGYVTQTWHPCLTKFTIKNQKREDVLKISGPCIVCSCIAGVDFEITSLDEQIVVGRISKHWSGFLREAFTDADNFGIQFPRDLDVKMKAVMIGACFLIDYMFFERTR
Protein: Cell adhesion molecule L1-like (M0RC17)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Contactin-6
Sequence:
MELPLGGRGLILSLIFLLLKLSTAEIPLSVHQVPTIVKQSYVQVAFPFDEYFQIECEAKGNPEPKFSWTKDDKPFDLSDPRIIAFNNSGTFRIPNEGHISHFQGKYRCFASNRLGTAISEEIEFIVPGVPKFPKEKIEPIDVEEGDSIVLPCNPPKGHPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPKLRTIVQKMPMKLTVNSLKHANDSSSSTEISNQANSIKQRKPKLLLPPAQIGSASSKTVLKGDTLLLECFAEGLPTPQIEWSKLGSELPKGRATIEIHEKTLKIENVSYQDRGNYRCTANNLLGKASHDFHVIVEEPPRWKKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGLPIENHPFPGDVMFPREISFTNLQPNHTAVYQCEASNIHGTILANANIDVVDVVPLIQTKNEENYETVVGYSAFLHCEYFASPKATVVWEVADETHPLEGGRYHTHENGTLEIERTTEEDAGSYSCWVDNTMGKAVITANLDIRNATKLRVFPKNPRIPKSHVLELYCESQCDSHLKHSLKLSWSKDGEAFEMNGTEDGRIVIDGANLTISNISGEDQGIYSCSAQTALDSTSGKTQVTVLGVPDPPRNLLLSERQNRSVRLSWEAGDDHNSKISEYIVEFEGNREEPGKWEELTRVRGEETDVVLPLAPYVRYQFRVTAVNEVGKSHSSQPSDHHETPPAAPDKNPHNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVSWKPQGAPEEWEEETVTNHTLRVMTPTVYAPYDVQVQAINQLGSGPEPQPVTLYSGEDYPSTAPVIHRVDVMNSTLVKVTWSSIPKETVHGLLRGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLEPFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPSFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYELGELNEINVTTPSKSSWHLSNLNATTKYKFYLKACTSRGCGKPISEEGATLGEGSKGIRKITEGVNVTQKSHPVEVLVPGAEHIVHLMTKNWGDNDSIFQDVIETRGREYAGLYDDISTQGWFIGLMCAIALLTLILLTVCFVKRNRGGKYSVKEKEDLHPDPEVQSAKDETFGEYSDSDEKPLKGSLRSLNRNMQPTESADSLVEYGEGDQSIFNEDGSFIGAYTGAKEKGSVESNGSSTATFPLRA
Protein: DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerases III 12.5 kDa polypeptide) (RNA polymerase III subunit C11) (Q04307)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in Pol III transcription reinitiation and RNA cleavage during transcription termination.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P32529}.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC5
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase III subunit RPC1
- DNA-directed RNA polymerase III subunit RPC9
- DNA-directed RNA polymerase III subunit RPC3
- DNA-directed RNA polymerase III subunit RPC4
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase III subunit RPC8
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
Sequence:
MLSFCPSCNNMLLITSGDSGVYTLACRSCPYEFPIEGIEIYDRKKLPRKEVDDVLGGGWDNVDQTKTQCPNYDTCGGESAYFFQLQIRSADEPMTTFYKCVNCGHRWKEN
Protein: m7GpppX diphosphatase (EC 3.6.1.59) (A0A384MTI8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|PIRNR:PIRNR028973}.
Interaction partners:
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
Protein: CMT1A duplicated region transcript 4 protein (Q8N9R6)
Organism: Homo sapiens (Human)
Interaction partners:
- Golgi apparatus membrane protein TVP23 homolog C
- Golgi apparatus membrane protein TVP23 homolog
Sequence:
MDARRMKKEEGLTENTGLPRKLLEKHDPWPAYVTYTSQTVKRLIEKSKTRELECMRALEERPWASRQNKPSSVIQPKRRKSSKSSGKAVFRDTLSESTLSMWGAYSVLAMAPTMIPEPTHLHADSRDCPTENYNKIIFARKPMMRMLPTVRY
Protein: Membrane-bound transcription factor peptidase, site 1 (Membrane-bound transcription factor protease, site 1) (Membrane-bound transcription factor site-1 protease isoform X1) (Membrane-bound transcription factor site-1 protease precursor (EC 3.4.21.112)) (Q1LWH3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004194}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004194}.
Interaction partners:
- Membrane-bound transcription factor peptidase, site 2.
- Activating transcription factor 6
- Sterol regulatory element-binding protein cleavage-activating protein
- Cyclic AMP-responsive element-binding protein 3-like protein 3-B
- Sphingosine-1-phosphate transporter SPNS2
- Sphingosine 1-phosphate receptor 2
- Sterol regulatory element-binding protein 2
- Sterol regulatory element-binding transcription factor 1.
Sequence:
MIVRLCLLVAFLGAKLPLVGTEEDSGPFLTPFPPPLPLNADAHLSPNCSQLTLKLDFSTQVVKHEYIVAFNGYFTAKARSDFISSALRDVDAVKWRIVRRDNPASDYPSDFEVVEIKQDTRNSLLTLQDHPYIKRVTPQRMVLRSLKFTDSGTDGASPCNDTRWVQKWQSWQSSRPLRRTSLSLSSGFWHATGRHSSRRLLRAIPRHVAQILQADVLWQMGHTGSGVKVAVFDTGLSEKHPHFKNVKERTNWTNEKTLDDGLGHGTFVAGVIASMRECQGFAPDSELHIFRVFTNNQVSYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANKVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRVKPDIVTYGSGVRGSGLKEGCRSLSGTSVASPVVAGAVTLLASTVLNRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTIVNVTILNGMGVTGRIVEKPIWQPYLPQNGDYVDVAVSYSPVLWPWAGYLAVSISVAKKAASWEGIAQGHVMVTVASPAENDSAIGGEMTSTVKLPVKVKIVPTPPRSKRILWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPITCFDASQYGTLLMVDSEEEYFPEEITKLRRDIDNGLSLIVFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANVPALNDLISVWGMAFSDGLYEGDFTLADHDMYYASGCSIARFPEDGIVIAQTLKDQGLEVLKQETAVVENVPVLGLYQTPSDGGGRIALYGDSNCIDDSHRQKDCFWLLDALLQYTSYSMTPPSLTHSKNRLVPPTGTDRPLPQRLEGNHLYRYSKVLEAHLGDPKPRPLPACPHLSWAKPQPLNETAPSNLWKHQKLLSVDMDKVVLPNVRAYRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPMFAFLGAMVVLSFFVVQLTKAKSKPKRRKPRVKRPLYLQQQQQQQQTPHSGKNPTV
Protein: Oxysterol-binding protein-like protein OBPalpha (Q9UW21)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MGLTAKLDKLKLKTTSEDIEDDSGHAKPDNSDDIDEVDSEYQNILLSIIAQLRPGMDLSKITLPTFILEKKSMLERITNFFQIPKLLIDSNSIEDPLDRFIGVLRWYLASWHISPKAVKKPLNPVLGEVFTCYWDELPNNKSAYYLSEQISHHPPKSSYFYIMPEEKIRVDGVVIPKSRFLGNSSAAIMEGCGYVTLGKWDNEVYVMNQPNVYVRGILFGKMRTELGDHMYVKCERNGLEANIEFKTKGFIYGTYDAIEGIIKDSETQKELFQISGKWNEVMYIKNIKTGKKEVLYDTRGSKTLKPKVRPLEEQWDFESRKLWKPTIAGLAKRNHELATEEKSKVENEQRIKAKKRLEDGVEFHPKFFREVNENDNGVKNLEYVIYKKFDLKEDPEVLRERLFTVAPIVPGQKFDEKFHYPAFKKPESN
Protein: Peptidase, M42 (Glutamyl aminopeptidase) family (A0A0H2UP05)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MNQTVEYIKELTAIASPTGFTREIADYLVKTLEGFGYQPVRTSKGGVNVTIKGQNDEQHRYVTAHVDTLGAIVRAVKPDGRLKMDRIGGFPWNMIEGENCTIHVASTGEKVSGTILIHQTSCHVYKDAGTAERTQDNMEVRLDAKVTSEKETRALGIEVGDFISFDPRTVVTETGFIKSRHLDDKVSAAILLNLLRIYKEEKIELPVTTHFAFSVFEEVGHGANSNIPAQVVEYLAVDMGAMGDDQQTDEYTVSICVKDASGPYHYDFRQHLVALAKEQDIPFKLDIYPFYGSDASAAMSAGAEVKHALLGAGIESSHSYERTHIDSVIATERMVDAYLKSTLVD
Protein: dipeptidyl-peptidase IV (EC 3.4.14.5) (H3BQ40)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDI
Protein: Probable [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial (Pyruvate dehydrogenase kinase) (EC 2.7.11.2) (Q02332)
Organism: Caenorhabditis elegans
Function: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism (By similarity). Required for normal lifespan.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q15118}.
Interaction partners:
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- 2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein
- Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
- PPM-type phosphatase domain-containing protein
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- Probable cytochrome c 2.2
- Cytochrome c 2.1
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
Sequence:
MRFSRKLLGPFVGSLAKKLDYYSQFQPSSLTIQQYLDFGRIGTSANSYTFLKNELLVRLANIMQEFTLLPPKLLQMPSSKMVSNWYAESFEDLLLFEASDSSPEQVARFNDQLTVVLKRHAHVVETMAEGLIELRESDGVDIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGNVLPESPRHVGCIDPACDVESVVYDAFENARFLCDRYYLTSPSMKLEMHNAVEKGKPISIVAVPSHLYHMMFELFKNAMRATVEYHGVDDDLPDIKVYVVKGQEDLSIKICDRGGGVSRTILERLYNYMYSTAPPPPRDGTQAPLAGYGYGLPLSRLYARYFLGDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQVADWSHHVPGQGNRPAQS
Protein: Dynein arm light chain, axonemal, putative (Q385L7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Dynein regulatory complex subunit 2
Sequence:
MPTRPLLVKYETPVLLSEVKHKKALKEKKRVAVGAQSGPQAEDVLYSIIPPREFEENGQQWVQYVSSIPATRMDVINLQERLDSLLLERNARETGICPVREELYSQVFDELIRQVTVNCAERGLLLLRVRDELRMTLDAYRSLYESSAAYGMRKALQAEQSKIEMESKIQALEREKEELKQQVEELEYRCESIIQQEKEKFAEAERKHNEEVAFFRRTYQTLTTNLQTLCNATKA
Protein: Nodulin-like domain-containing protein (Q385G4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MHLEQAGERTYALGCTLERRWFLQFFVSILICLNNGACFCFGIFTPFMKGGAFMFNQSQVNVLSTIGVIFSYFSLPTGFLYDAKGPKVTLMVGTVLNVVGWLGMMLIFLKPEDPLMGTSLWVMSLFYAISQFSASFYETGSLLTNLDAFICYQGRVILVQKTFMGLGSSLIVQIYIAFFEIHFDGIWPFFLFLVLYSFTVGVLGTLFVRLPTEKTQCLGLSIPDKGVVASGGGESSLFKVPFNVGTGILFVAIMYTFIVTMVENYREISVSDRHIIGITTIILCVSFLFMILATPSYSNNVGGYHSRSANSSWSSHLVDEMTTTVPGQNNCNSQRAPTEAVDNETARRCDVNAPDAEGIGRGRGVSKDDTNGLNEREPTEPQNGDNLLNPNEEGRRAAERSNHERTVNNSEVVAELQGIKLNGDSLLTNILRREMWVMWYSCLAAWSSATLVSTNSTQIYKALNFDNYSSTVNVAYVSIYGVASAVGRVIVGSIHPMLVSRKIPISIFLCGAPVLNIIGLPLFIFIPKSALFLPFFIIGLATGVSWGSTILVIKSLFAPTSCGKHYAVLFTAGIVSPIIFNVGLFGPIYDHYSKKQGLWDVRECVGTVCVWIPLVVCAIVNVLALPLAVYFFLRIKKRGGFIY
Protein: E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) (Q8CFI0)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes (By similarity). Involved in the regulation of TOR signaling (By similarity). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF. Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12050153}. Golgi apparatus {ECO:0000250|UniProtKB:Q96PU5}. Endosome, multivesicular body {ECO:0000250|UniProtKB:Q96PU5}.
Interaction partners:
- Epithelial sodium channel subunit alpha
- Serine/threonine-protein kinase Sgk1
- Epithelial sodium channel subunit beta
- Mothers against decapentaplegic homolog 3
- Epithelial sodium channel subunit gamma
- Mothers against decapentaplegic homolog 2
- E3 ubiquitin-protein ligase NEDD4
- Mothers against decapentaplegic homolog 7
- 14-3-3 protein sigma
- Disks large homolog 3
Sequence:
MSLCEAPVHVGDKELKYFQIPQMLSQLSLLASHHSRGLEFSGGQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGPEPWETISEEMNMAGDSLSLALPPPPASPVSRTSPQELSEEVSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDTVAEQAHLPPPSTPTRRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLVEPQIRRPRSLSSPTVTLSAPLEGAKDSPIRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Protein: Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4) (Q8NFF2)
Organism: Homo sapiens (Human)
Function: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived (By similarity). May play a role in calcium transport during amelogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26631410}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8CGQ8}.
Interaction partners:
- Two pore channel protein 2
- P protein
- Membrane-associated transporter protein
- Ras and Rab interactor 3
- Zinc finger CW-type PWWP domain protein 1
- Thioredoxin domain-containing protein 3
- Tyrosinase
- Melanocyte-stimulating hormone receptor
- Cas scaffolding protein family member 4
- Phospholipid-transporting ATPase ABCA7
Sequence:
MALRGTLRPLKVRRRREMLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD
Protein: Nephrocystin 1 (Nephronophthisis 1 (Juvenile), isoform CRA_g) (C9J082)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEYASFLPFFFLF
Protein: Ovochymase-2 (EC 3.4.21.-) (Oviductin) (Q7M761)
Organism: Mus musculus (Mouse)
Function: May be required for sperm ADAM3 processing and consequential sperm fertilizing ability. In vitro, has an endopeptidase activity (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P79953}.
Interaction partners:
Sequence:
MPISKDKLILILGMVCLEQGHSETLSSIRNPDCGQSLVKPQPQNYFSLFSRIVGGSQVEKGSYPWQVSLKQKQKHICGGTIISSQWVITAAHCMANRNIALTLNVTAGEHDLSQAEPGEQTLAIETIIIHPQFSTRKPMIYDIALLKMAGTFQFGQFVRPVCLPEPGEHFNAGFICTTAGWGRLSEGGRLPQVLQQVNLPILTQEECEAVLLTLKNPITGKTFLCTGSPDGGRDACQGDSGGSLMCQNRKGAWTLAGVTSWGLGCGRSWRNNARKKEQGSPGIFTDLRRVLPWILKHIQTGHRRKSTKALCSEPDGLISGSEGELHFPESLHLYYESKQLCVWTFLVPEDMHMLLNLSHLDIESCHHNYLAMYSLEDRLVGKFCGENLPSSILIGSSSIRLRFISDATDYATGFNLTYKALKPRYHPDSGCRSLTILFEEGTIQSLHYPEDYSNMASCTWIFQAPNYCLIKLSFQSLEIEENGDCSSDYVTVHSDVEKEKEIARFCDYVIPSPVLSSSSVMLISFQSDENGTARGFQADISFISRADLNISISEDESVPLETWDLPPGAMEIFDAERDTHTKPPYEEDIGEMPAIDSGLLKQGERRGKH
Protein: DNA 5'-3' helicase (EC 5.6.2.3) (Q6TY70)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
AELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAVDGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNHLTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRNADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISDLTEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVVITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNYGQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETXDNAETSYALMNYVKACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIRENDFLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHXVDSFCNLSTEEAVQLARRWLRRMAQPXTREDQLGIXLLTLAQLENMEQEKLERQAQGKQGVGGEVQEL