wanglab/gogpt-training-data huggingface dataset:
Protein: Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta) (P37242)
Organism: Mus musculus (Mouse)
Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Subcellular location: Nucleus.
Interaction partners:
- Nuclear receptor corepressor 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Nuclear receptor coactivator 2
- Nuclear receptor coactivator 1
- Nuclear receptor corepressor 2
- Thyroid hormone receptor alpha
- Mitogen-activated protein kinase 3
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Mitogen-activated protein kinase 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Sequence:
MTPNSMTENGLPAWDKQKPRPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSPHLIQATWTSSIFHLDPDDVNDQSISSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Protein: Chaperonin GroEL (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin-60) (Cpn60) (Heat shock protein 60) (Q5SLM2)
Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Function: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00600}.
Interaction partners:
Sequence:
MAKILVFDEAARRALERGVNAVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENIGAQLLKEVASKTNDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAVEAAVEKIKALAIPVEDRKAIEEVATISANDPEVGKLIADAMEKVGKEGIITVEESKSLETELKFVEGYQFDKGYISPYFVTNPETMEAVLEDAFILIVEKKVSNVRELLPILEQVAQTGKPLLIIAEDVEGEALATLVVNKLRGTLSVAAVKAPGFGDRRKEMLKDIAAVTGGTVISEELGFKLENATLSMLGRAERVRITKDETTIVGGKGKKEDIEARINGIKKELETTDSEYAREKLQERLAKLAGGVAVIRVGAATETELKEKKHRFEDALNATRAAVEEGIVPGGGVTLLRAISAVEELIKKLEGDEATGAKIVRRALEEPARQIAENAGYEGSVIVQQILAETKNPRYGFNAATGEFVDMVEAGIVDPAKVTRSALQNAASIGALILTTEAVVAEKPEKKESTPASAGAGDMDF
Protein: GTP-binding protein RAD (O88667)
Organism: Mus musculus (Mouse)
Function: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17525370}.
Interaction partners:
Sequence:
MTLNGGSGASGSRGAGGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALAPGSLATTAAGTRTQGQRLDWPEGSSDSLSSGGSGSEEGVYKVLLLGAPGVGKSALARIFGGIEDGPEAEAAGHTYDRSITVDGEEASLLVYDIWEEDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEDNARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL
Protein: GTP-binding nuclear protein ran-1 (Ras-related nuclear protein 1) (O17915)
Organism: Caenorhabditis elegans
Function: Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:11909538}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11909538}. Chromosome {ECO:0000269|PubMed:11909538}. Note=At interphase, ran-1 is localized to the nucleus and the nuclear envelope. At prometaphase, ran-1 is still localized to the nuclear envelope. When the nuclear envelope begins to disassemble at M phase (early metaphase), ran-1 is localized throughout the entire cell. At late metaphase, ran-1 localizes to the kinetochore regions, this persists until anaphase. At telophase, ran-1 is localized around the decondensing chromosomes.
Interaction partners:
- Ran GTPase-activating protein 2
- Importin N-terminal domain-containing protein
- Regulator of chromosome condensation
- Importin N-terminal domain-containing protein
- Nuclear Pore complex Protein
- Exportin-T
- Probable nuclear transport factor 2
- Elongation factor 1-alpha
- Exportin-2
- Importin N-terminal domain-containing protein
Sequence:
MSGGDGIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGQIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTARVTYKNVPNWHRDLARVCENIPIVLCGNKVDVKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLLGDPNLEFVAMPALAPPEVQMDPAMIAEYEKDLDNAAKADLPDDDDDL
Protein: Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) (P36507)
Organism: Homo sapiens (Human)
Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10409742}. Membrane {ECO:0000269|PubMed:10409742}; Peripheral membrane protein {ECO:0000269|PubMed:10409742}. Note=Membrane localization is probably regulated by its interaction with KSR1. {ECO:0000269|PubMed:10409742}.
Interaction partners:
- Mitogen-activated protein kinase 1
- Serine/threonine-protein kinase B-raf
- Serine/threonine-protein kinase A-Raf
- Dual specificity mitogen-activated protein kinase kinase 1
- RAF proto-oncogene serine/threonine-protein kinase
- Mitogen-activated protein kinase 3
- Kinase suppressor of Ras 1
- Mitogen-activated protein kinase kinase kinase 1
- GTPase NRas
- GTPase HRas
Sequence:
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
Protein: Calsequestrin (A0A060WP64)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Sarcoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004564}.
Interaction partners:
- Aspartyl beta-hydroxylase/Triadin domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Triadin
- Aspartyl/asparaginy/proline hydroxylase domain-containing protein
- Aspartyl/asparaginy/proline hydroxylase domain-containing protein
- Aspartyl beta-hydroxylase/Triadin domain-containing protein
- Uncharacterized protein
- Calsequestrin
- Calsequestrin
Sequence:
MLALWLLLLPCLSLSPLVQTEKGLEFPRYDGKDRVIDINNKNYQKAMKKYTMMCLLYHKPIPDGKELQKQHLMTEMVLELAAQVMEEKEIGFGMVDSDKDTKVAKKLGLVEEGSVYVFKADRVIEFDGMLSADTLVEFLLDLLEEPVEVIGNALELRAFDRMEEDIRLIGYFKNEDSEHYSAFKEAAEQFQPYIKFFATFEKAVAKELTLKMNEVDFYEPFMEEPVTLPDRPNSEEEIVAFVTEHRRPTLRKLRAEDMFETWEDVVEGSHIVAFAEEEDPDGYEFLELLKEVARDNTHHPGLSIIWIDPDDFPLLIPYWEKTFQVDLFKPQIGVVNVTDADSIWLEMEEQDLLTAQKLADWIENVLSGKVNTEDDDDDNDDDEDDDDDDDDDDSDDDSDDDSDDSDDSDDEEDEDDDDE
Protein: SOS Ras/Rho guanine nucleotide exchange factor 2 (A0A0G2JVU2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MQQAPQPYEFFSEENSPKWRGLLVPALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCLAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDDIGLVSLCEEEPCSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDKKLFKSSEIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILAPEFNDHFSKLMARPAVALHFQQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHCQTRLPGYSSAEYRLKEKFVMRKIQICDKEDACEYKHAFELVSKDENSVIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPRPDVYRFVVTDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPDPEPTEADKLALEKGEQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLEAFISSVRGKAMKKWVESIAKIIKRKKQAQANGVSHNITFESPPPPVEWHISRAGQSETFDLMTLHPIEIARQLTLLESDLYRRVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRVLDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGLLSEKEFTDYLFNKSHEIEPRNCKQPPRFPRKSTFSLKSPGIRPNASRHGSTSGTFRGHPTPLEREPYKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKSFFSSCGSLHKLSEEPLVPPPLPPRKKFDHDAPNSKGAMKSDDDPPAIPPRQPPPPKVKPRAPVLTGTFEGPVPSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVSTCPNSPSTPPPTPSPRIPRRCHLPSPSHNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLFENAETPQ
Protein: RNA exonuclease NGL2 (EC 3.1.-.-) (Carbon catabolite repressor protein 4 homolog) (Q03264)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-rRNA processing. Required for the final stage of 3'-end maturation of 5.8S rRNA at site E.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- RNA exonuclease NGL1
- Oligoribonuclease, mitochondrial
- RNA exonuclease 3
- RNA exonuclease 1
Sequence:
MTQDKEVKVVAPDVAPDQEVEINKSVKDAKHQTNDDSLLQHKKKGKKGKKSKPIVTPEHIAKVRAEREVMRKAKRDAMLAQGVDPDCPPELHFIRRPFLSLHEAEPVTGFRFKLMTYNCLAQALIRRKLFPDSGDALKWYRRSKVLLNEFKYYNSDVICLQEIDHIQFQSFWKDEFSKLGYDGQYYRNATKNHGVAIMWRRELFHQVDKMLIDYDKESSESISTRTTTNNVGLVLALKFSEKVLSNLGKKSSKKCGILIGTTHLFWHPFGTYERTRQCYIVLKKMKEFMHRVNVLQNENDGDLSHWFPFFCGDFNSQPFDTPYLSMTSKPVHYRNRAKTVIGCSTSYKFSKVRDGEEGADDEEGGNIEKYGKDQPESPVPEKFHANEEQSELVDKMAQLHNSLDMRAISLYSVGYKNVHPENAGLDNDRGEPEISNWANTWRGLLDYLFYVKKWDPQSNCQEVETLGDFEKENKVKCRGFLRMPPGNEMTKHGQPHVGEYASDHLSMVCDLELQL
Protein: Low-density lipoprotein receptor-related protein 12 (LRP-12) (Q8BUJ9)
Organism: Mus musculus (Mouse)
Function: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor (By similarity).
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Membrane, coated pit {ECO:0000250}.
Interaction partners:
Sequence:
MARRWSTKESQRRGSAWLLLFLAGVYGNGALAELSENVHISGVSTACGESPEQIRAPSGIITSPGWPSDYPAQVNCSWLIRANPGEIITISFQDFDIQGSRRCTLDWLTIETYKNIESYRACGSTIPPPYISSQDHVWIRFHSDDSVSRKGFRLAYFSGKSEQPDCACDQFRCGNGKCIPEAWKCNSMDECGDSSDEEVCASDAHPPTTTAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDMPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPRKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDEINCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSIRLPMTGRSSNIWNRIFNFARSRHSGSLALVSGDGDEVVPSQSSSRETERSRPHRSLFSVESDDTDTENERRDTAGASGGVAAPLPQKVPPTTAVEATVGSGGNSSAQSTRGGHADGREVSSVEAPSVSPARHQLTSALSRMTQGLRWVRFTLGRSSSTTQNRSPLRQLDTAVSGREDDDDVEMLIPVSDGASDIDANDCSRPLLDLASDQVQGFRQPHSAGNPGVRTSNRDGPCERCGIVHTAQIPDTCLEATVKTETSDDEALLLC
Protein: 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (O88736)
Organism: Mus musculus (Mouse)
Function: Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis. Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1)to a more potent estrogen, 17beta-estradiol (E2). Converts moderately dihydrotestosterone (DHT) to their inactive forms 5a-androstane-3beta,17b-diol and 5alpha-androstane-3alpha,17beta-diol. Does not metabolize progesterone. Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12829805}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with HMGCR in a wide range of tissues during embryonic development. {ECO:0000269|PubMed:12829805}.
Interaction partners:
- Methylsterol monooxygenase 1
- Lathosterol oxidase
- Lanosterol 14-alpha demethylase
- Squalene synthase
- Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
- Lanosterol synthase
- Ergosterol biosynthetic protein 28 homolog
- Delta
- 17-beta-hydroxysteroid dehydrogenase type 1
- Very-long-chain 3-oxoacyl-CoA reductase
Sequence:
MRKVVLITGASSGIGLALCGRLLAEDDDLHLCLACRNLSKARAVRDTLLASHPSAEVSIVQMDVSSLQSVVRGAEEVKQKFQRLDYLYLNAGILPNPQFNLKAFFCGIFSRNVIHMFTTAEGILTQNDSVTADGLQEVFETNLFGHFILIRELEPLLCHADNPSQLIWTSSRNAKKANFSLEDIQHSKGPEPYSSSKYATDLLNVALNRNFNQKGLYSSVMCPGVVMTNMTYGILPPFIWTLLLPIMWLLRFFVNALTVTPYNGAEALVWLFHQKPESLNPLTKYASATSGFGTNYVTGQKMDIDEDTAEKFYEVLLELEKRVRTTVQKSDHPS
Protein: Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) (P48765)
Organism: Bos taurus (Bovine)
Function: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1416984, ECO:0000269|PubMed:2334719}; Multi-pass membrane protein {ECO:0000269|PubMed:2334719}.
Interaction partners:
- Sodium/calcium exchanger 1
- cGMP-dependent protein kinase 1
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Solute carrier family 8 member A3
- cGMP-dependent protein kinase
- Ryanodine receptor 2
Sequence:
MLQFSLSPTLSMGFHVIAMVALLFSHVDHISAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVSSPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVDSFLDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVAENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVKVSLEASEDGILEASHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLYGQPVFRKVHAREHPLPSTIITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTRLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFACTIALKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
Protein: 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (Proteasome 26S subunit ATPase 4) (S6 ATPase) (Tat-binding protein 7) (TBP-7) (Q63570)
Organism: Rattus norvegicus (Rat)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P43686}. Nucleus {ECO:0000250|UniProtKB:P43686}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 2
- 26S proteasome regulatory subunit 10B
- 26S proteasome non-ATPase regulatory subunit 1
- 26S proteasome regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome regulatory subunit 6A
- 26S proteasome non-ATPase regulatory subunit 12
- Proteasome subunit beta type-2
- Proteasome
Sequence:
MEEIGILVEKIQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
Protein: PrimPol-like protein 2 (Q38BZ3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGPKTQEARPPLPGTPMPPIDPIFAITGPSAGVLHVNTADLLPDQRNKLDDNISRAISDCLKSVVVPLDRYWRAASQHHTLLCSTSEDGAVDSSNTEGATPSHWPAAERIPDPENIPYTFYSTRMEAIIRRSYQKDRGEVLVAADVRSGNSGKIFNTLRRREIASFVNAIPLVPQRNLYVMIDKDAAVDPFFDIDCSPPFEWLNFPTEVAEGENLPSNGSRAKDSSSQPPVHIDTAVVERCLLQILQYLRDVVEEYAGAKLEHCLVLTGSVLVSESSVGPSAHTGATRRHNLLSSKDTKLSFHVHFRLEKNVVFSNIRELHKFMMKIRGGIDDSFNKAGDRETRSFYHMLQCCIDFGVYSRWRAFRLPYNVKASSDGLNTMNAASFNSAIDAATKSPFRTALIPNLSVGEASHSIVHEIDLSTLQDSLLYFEPTKKQQEHHALLTKLFGVFRFLLPVVPKVTAIGNAELAKFLLAHQPPFPPTEESVNPSYRDDLARVVFELALIQRDASNLMNEGDDKNTFNFIMWSDSAEDERDNALIQGPFGINRPPLRDGARAPVRDSRIKKLIAEVFHCLSPAFGGGLKSNLQAQSSDILRQSGSYITADSLSVDYQDGVRFYYVRQKSSKFCIRLGREHRSTYPQLYLTYGSIKIRCYSNDCSGKCHCLKWSPNDNERICGSSAVLLSVDDNGYPKYDRLAEIRDLLFPPLSQEELIRRYGITSVASGDEDIVQQW
Protein: UPF0438 protein YifE (P0ADN2)
Organism: Escherichia coli (strain K12)
Interaction partners:
- HTH-type transcriptional regulator HdfR
- Negative modulator of initiation of replication
- Lipopolysaccharide export system protein LptC
- Met repressor
Sequence:
MAESFTTTNRYFDNKHYPRGFSRHGDFTIKEAQLLERHGYAFNELDLGKREPVTEEEKLFVAVCRGEREPVTEAERVWSKYMTRIKRPKRFHTLSGGKPQVEGAEDYTDSDD
Protein: Rhodanese domain-containing protein (Q382H6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGQSTSYEELDRKRALNKFHMAALLKSKRSGKSENTFIVDVRDAFEVKRYGTIPFSVHIPSSEVRSAFRMSPTAFETKYKIRMPQASDKIVFFDQRHGRAATAVDVVEALGYRAATYFADGYNEWSKFTQGEQEEDL
Protein: JmjC domain-containing protein (Q27GT3)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKMKYYHDYMLNNKDDSPLYIFDSSFAERRKTKKLSEDYSVPKFFEDDLFHYADDKKRPPHRWFVMGPARSGTAIHIDPLGTSAWNSLLQGHKRWVLIPPIAPRDLVKPMAHEKGKHPDEGITWFQTVYKRVRSPSWPKEYAPIECRQGPGETMFVPSGWWHVVINEEYTIAVTHNYCSVENLHLVWPKTVKGRPKLSKHWVKRLTEQRPELLEIIKSASEIPLYDMNESSSDSSSSSSSSDDSSDESDCDDSGRCGGRKRKNDDRSNECPEKMSTTYFQNSLV
Protein: Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule) (Q9H400)
Organism: Homo sapiens (Human)
Function: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:14610046}; Single-pass type III membrane protein {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:14610046}. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
Interaction partners:
- Tyrosine-protein kinase Lck
- Growth factor receptor-bound protein 2
- GRB2-related adapter protein 2
- Tyrosine-protein kinase Lyn
- GRB2-related adapter protein
- SLC2A4 regulator
- Zinc finger CCCH-type with G patch domain-containing protein
Sequence:
MGLPVSWAPPALWVLGCCALLLSLWALCTACRRPEDAVAPRKRARRQRARLQGSATAAEASLLRRTHLCSLSKSDTRLHELHRGPRSSRALRPASMDLLRPHWLEVSRDITGPQAAPSAFPHQELPRALPAAAATAGCAGLEATYSNVGLAALPGVSLAASPVVAEYARVQKRKGTHRSPQEPQQGKTEVTPAAQVDVLYSRVCKPKRRDPGPTTDPLDPKGQGAILALAGDLAYQTLPLRALDVDSGPLENVYESIRELGDPAGRSSTCGAGTPPASSCPSLGRGWRPLPASLP
Protein: Serpin 77Bb (Q9VWB4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH21475p
- Male accessory gland protein
- Serpin 38F, isoform A
- Serpin 85F
- IP10416p
- Accessory gland-specific peptide 26Ab
- Ejaculatory bulb-specific protein 2
- Seminal fluid protein 24C1
- FI01422p
- Serpin 28F
Sequence:
MKLGFLGLFGMVLMIMFYEGAEGYTVNELRDVLGIYVDYPTLRRWYEDVRAYHYLNSENTKLFSLRYAYYDDVGDLELVKGYNSVVLEGVGEGNVVLREGRPRGVDFDQGASIIINDDIDKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAKWKYPFDKSQTKVEQFYNDGGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPFGEHELVMIVLLPKSSQGVNLVLYQLKNLGLHRLLEKLEASKNETDVEVKLPKFDTRSVLSLEDTVYDAGLTDLRNDFADLDKLLIAIGHRGACLTLYHQFARIVVDEEGLPNAVPQKSSGKNNIKFHVNRPFAYLVLQKKHKLLIHSGVFREGEIQ
Protein: Regulator of G-protein signaling 17 (A0A8I5ZV65)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MFFNKLLLRCQSDSEAADMRKRQQSQNEGTQAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVRNEERGDSSGRPPHTTKMESIQVLEECQNPTADEVLSWSQNFDKMMKAPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRNLLEPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAFVESTASSTSES
Protein: Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (Q6AWS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU368074}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU368074}.
Interaction partners:
- Translocon-associated protein subunit beta
- AT5G58370 protein
- UPF0496 protein At3g19250
- Oxysterol-binding protein-related protein 2B
- Translocon-associated protein subunit alpha
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- PH, RCC1 and FYVE domains-containing protein 1
- 30-kDa cleavage and polyadenylation specificity factor 30
- Carboxymethylenebutenolidase homolog
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A
Sequence:
MRTSFRLLFFAFLLLVSPFLKVALCQSDSEDSGFEVSDVGEEESDAEEVFGLELTSAPGIETLCVFPKNSAKIIKAGVETELLVGMKNDGQSNVDIVAVKGSLHLPFDQNAVQNLTALSFSNASVPTSAQATLPYAFAVSKFLQAGAFDFVGTIIYEIDGKPYQSIFYNGTIEVVEDGPLFRMESVFLSGLLIFVIAFLAIYIQNVLKHMTKKTKRAPKVEVGTATKDASHDEWLEGTSYTQSSSKSKKKK