wanglab/gogpt-training-data huggingface dataset:
Protein: Large ribosomal subunit protein uL16-like (60S ribosomal protein L10-like) (P86048)
Organism: Mus musculus (Mouse)
Function: Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I. Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (By similarity). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (By similarity). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:36517592}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein eL27
Sequence:
MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDKVAAKRLIPDGCGVKYIPERGPLDKWRALHS
Protein: Sodium-dependent serotonin transporter (5HT transporter) (5HTT) (Cocaine-sensitive serotonin transporter) (dSERT1) (P51905)
Organism: Drosophila melanogaster (Fruit fly)
Function: Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8197200, ECO:0000269|PubMed:8302852}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7K4Y6}.
Interaction partners:
- 5-hydroxytryptamine receptor 2A
- GH10249p
- Tryptophan 5-hydroxylase 2
- 5-hydroxytryptamine
Sequence:
MDRSGSSDFAGAAATTGRSNPAPWSDDKESPNNEDDSNEDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQPEDNCGSVVPGQQGTSV
Protein: Ribonuclease P protein subunit p21 (RNaseP protein p21) (Ribonuclease P/MRP 21 kDa subunit) (Ribonucleoprotein V) (Q9H633)
Organism: Homo sapiens (Human)
Function: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:11497433}.
Interaction partners:
- Ribonuclease P/MRP protein subunit POP5
- Ribonucleases P/MRP protein subunit POP1
- Ribonuclease P protein subunit p30
- Ribonuclease P protein subunit p29
- Ribonuclease P protein subunit p14
- Ribonuclease P protein subunit p38
- Ribonuclease P protein subunit p40
- Ribonuclease P protein subunit p25
- Ribonuclease P protein subunit p20
- Mitochondrial ribonuclease P catalytic subunit
Sequence:
MAGPVKDREAFQRLNFLYQAAHCVLAQDPENQALARFYCYTERTIAKRLVLRRDPSVKRTLCRGCSSLLVPGLTCTQRQRRCRGQRWTVQTCLTCQRSQRFLNDPGHLLWGDRPEAQLGSQADSKPLQPLPNTAHSISDRLPEEKMQTQGSSNQ
Protein: GM08694p (Q8T3M5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTDSKGVQGVTSRLTGVESIQLCSYRIQPCERLQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDEPDRSCRVGCQDEFIKYRYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCLEFGDDDLPLDKTHISLGQLRTRRKRSSTSNDLFNVTEIFIKPSHSDISSENIEFTQPIHVSADELSSKSR
Protein: Mannan-binding lectin associated serine protease 3 (Q6Q1Q8)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MRYPLAWSMCAWLLGVVGAVELTDMFGEIRSPNFPDSYPSDSEVTWNISVPEGFKIKLYYMHFDLESSYLCEYDYVKIEAEDQELATFCGRETTDTEQAPGQQVILSPGPYMGLTFRSDFSNEERFTGFDAHYTAVDVDECLEKSDEELACDHYCHNYIGGYYCSCRFGYILHSDNRTCKVECSDNLYTQRSGVVTSADFPSPYPKSSDCLYRIELEDGFFITLSFEDSFDVEDHPEVTCPYDYIKIKAGQREFGPFCGEKSPGRIETQTNSVQILFHSDNSGENRGWKLSYTAIGNPCPLVQPPINGKIEPSQAKYTFKDQVVISCNTGYKVLKDNLESDSFQIECLKDGTWSNKIPICKIADCQAPPELEHGFVTFLSRNNLTTYRARIQYHCQHPYYHMAPNSTATYTCDASGVWRSEELGTVLPSCRPVCGRPVRALPGIIKRIIGGRNAEPGFFPWQALIVVEDMSRVPNDKWFGSGALLSDSWVLTAAHVLRSQRRDKTVIPVSKEHVTVYLALHDVRNKLEAVNRTVERIILHEDFDIQNYNHDIALVKLKEKVTMGNYVMPICLPQFEHELEGPHPNTLGLVAGWGISNPNITVDEIISSGMRTLSDILQYVKLPVVLHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIQDPGTRRWVAQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVEKNTGSSERWTFLDPELER
Protein: MFLJ00385 protein (Q6KAM2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
EEPRIPKPSTPPGSSCPPGNILGGPSVFIFPPKPKDALMISLTPKVTCVVVDVSEDDPDVHVSWFVDNKEVHTAWTQPREAQYNSTFRVVSALPIQHQDWMRGKEFKCKVNNKALPAPIERTISKPKGRAQTPQVYTIPPPREQMSKKKVSLTCLVTNFFSEAISVEWERNGELEQDYKNTPPILDSDGTYFLYSKLTVDTDSWLQGEIFTCSVVHEALHNHHTQKNLSRSPELELNETCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVQVKQTAIPDYRNMIGQGA
Protein: Protein LNK2 (Night light-inducible and clock-regulated 2) (F4JCX9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1. Antagonizes REV8 function in the regulation of anthocyanin accumulation. Involved in red light input to the clock. Activates clock-controlled genes with afternoon peak. Mediates light inhibition of hypocotyl elongation. Unable to bind to DNA, but recruited to the evening element (EE)-containing region of the PRR5 and TOC1 promoters through its interaction with the DNA binding proteins REV8 and REV4.
Subcellular location: Nucleus {ECO:0000269|PubMed:25012192}.
Interaction partners:
- Protein LHY
- Protein CCA1
- Protein REVEILLE 8
- Protein LNK4
- Protein LNK3
- Protein REVEILLE 4
- Two-component response regulator-like APRR9
- Protein REVEILLE 6
- Two-component response regulator-like APRR5
- WD repeat-containing protein LWD2
Sequence:
MFDWEEEELTNMIWGDDAETGDHIVPFKVRSEQLNKKEQIEESKTAEQKITGTKIDLHDKNLGSSSSHNVDEGLPQPDFCMSSWPDTSLTNATKVDQDLSATELSKCLAEPVRYDSTRGGAFLLKQSCFTWVRSFQSNHFKSCVLTLFLPEKTSELGKGPDIFHSSDESKEQGDFDDYSWANIGSFDDLDRMFSDGFAAMMSLYLVMAVSAVVMSYGHLLKITEFEQQENQQFPLTGKANGLSSQSVPSVRVTLKADQYREHKGQPSVEDQPYQQNKMMKFSKMPGTSEARPFQELYGQRIPFSNSAGKCVNQLAPPQSSLMAVNLLSESEGSGTSHYSHMPNQYMANSAFGNLANPYSSVPVISAVQHPDVRNQLMHPSYNPATATSVNMATDASARPSTMTPQEKLEKLRRRQQMQAMLAIQRQQQQFSHQVPVADQSITQNCLQDIPLQLVDKTNLQGLTAMPSFDPSSSLEQDDSGKFAAAVDNSAEFAVLYRLQDVVAKLDMGTRTCIRDSLFRLAGSAAQRHYTSDTSHSNKTSQDDQEVIPREESRYRYAGMPDTEAVTNPTDRTVAHLLFHRPFDMLAAKRMEGPESPASSKMGTEEKGNFPKCSIRETHLTKQKAQKEEGPADSLALGNAPNSGSSSTVGERVVEASQGNKRKL
Protein: Paxillin (F1MFD1)
Organism: Bos taurus (Bovine)
Subcellular location: Cell junction, focal adhesion {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Tyrosine-protein kinase
- Vinculin
- Talin 1
- Talin 2
- Parvin alpha
- Focal adhesion kinase 1
- GIT ArfGAP 1
- Adapter molecule crk
- Zyxin
- Scaffold protein ILK
Sequence:
RPVFLSEETPYSYPTGNHTYQEIAVPPVPPPPSSEALNGSVLDPLDPWPPSTSRFTHQQPQSSSPVYGSSAKTSSASNPQDGGGPPCPRAGEEDHVYSFPNKQKSAEPSPTVMSSSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGPLSTHYGVPENNSLLGGKAGALTKEKPKRNGGRGLEDLRPSVENLLDELESSVPSPVPTITVNQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVHGSFFEHEGQPYCEAHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
Protein: NudC domain-containing protein 2 (Q8WVJ2)
Organism: Homo sapiens (Human)
Function: May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20133715}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20133715}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20133715}. Note=Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.
Interaction partners:
- F-box only protein 24
- Nuclear migration protein nudC
- NudC domain-containing protein 3
Sequence:
MSAPFEERSGVVPCGTPWGQWYQTLEEVFIEVQVPPGTRAQDIQCGLQSRHVALSVGGREILKGKLFDSTIADEGTWTLEDRKMVRIVLTKTKRDAANCWTSLLESEYAADPWVQDQMQRKLTLERFQKENPGFDFSGAEISGNYTKGGPDFSNLEK
Protein: U6 snRNA-associated Sm-like protein LSm5 (Q9Y4Y9)
Organism: Homo sapiens (Human)
Function: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
Interaction partners:
- U6 snRNA-associated Sm-like protein LSm1
- U6 snRNA-associated Sm-like protein LSm6
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm4
- U6 snRNA-associated Sm-like protein LSm8
- U6 snRNA-associated Sm-like protein LSm2
- Small nuclear ribonucleoprotein Sm D2
- U6 snRNA-associated Sm-like protein LSm3
- Small nuclear ribonucleoprotein F
- U5 small nuclear ribonucleoprotein 200 kDa helicase
Sequence:
MAANATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV
Protein: 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) (Q922K7)
Organism: Mus musculus (Mouse)
Function: Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P46087}. Nucleus {ECO:0000250|UniProtKB:P46087}. Note=Localizes predominantly in the nucleolus and to a smaller extent in the nucleus. {ECO:0000250|UniProtKB:P46087}.
Interaction partners:
- mRNA turnover protein 4 homolog
- 60S ribosome subunit biogenesis protein NIP7 homolog
- GTP-binding protein 4
- MKI67 FHA domain-interacting nucleolar phosphoprotein
- Probable rRNA-processing protein EBP2
- Ribosome production factor 2 homolog
- Nucleolar complex protein 2 homolog
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- ATP-dependent RNA helicase DDX18
- Ribosomal L1 domain-containing protein 1
Sequence:
MGRKLDPTKKEKRGPGRKARKQKGAETELVRFLPAAGDENSKRLSSRARKRAAKRRAGSVDVPKPNKSPGIKTLPGELSKGAVQARGKKRPAPIQNSDGDEEEDSGEDDVVTQGDLWGSEDSDEDMVDDYGAASNSEDEEEKLLPIERAALKQKAQDATAGVLWNEEDTDEDEDDDGVSPESHPRKDDKAEGDLQINVEDEEAFVLPPAGETDQDGQAPDLQRVHKRIQDIVGVLRDFGAQREEGRSRAEYLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTNTLKTRRRDLAQLLINRGVNLDPLGKWSKSGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVNAASKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFQARRFHPTLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQPHAGNSAAATPTEPDLKDQVTPKSENGSQPTKKARGAVKAKQQLLRQPHSKKPFQKLNGIAKGPGLSTEPSVPDAQVSTRPSQSAGNADVNSKRKRSEKLKQRGPKWKPSKEAAVPKPSAPSRVEDSGTPVPTPSEIRAAPRPKDCAPSLGKAKKKQKGKQQLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAKRRKSMTKGNSQPLLS
Protein: Bombesin receptor subtype-3 (BRS-3) (P32247)
Organism: Homo sapiens (Human)
Function: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Gastrin-releasing peptide
- Neuromedin-B
- Gastrin-releasing peptide receptor
- Neuromedin-B receptor
- Coiled-coil domain-containing protein 80
- Sushi repeat-containing protein SRPX
- Bombesin receptor-activated protein C6orf89
- Neurotensin/neuromedin N
- Promotilin
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
Protein: D-lactate dehydrogenase (D-LDH) (EC 1.1.1.28) (Fermentative lactate dehydrogenase) (P52643)
Organism: Escherichia coli (strain K12)
Function: Fermentative lactate dehydrogenase.
Interaction partners:
- Formate acetyltransferase 1
- Pyruvate dehydrogenase
- L-lactate dehydrogenase
- Quinone-dependent D-lactate dehydrogenase
- PFL-like enzyme TdcE
- Pyruvate kinase I
- NADP-dependent malic enzyme
- Phosphoenolpyruvate synthase
- Pyruvate dehydrogenase E1 component
- NAD-dependent malic enzyme
Sequence:
MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV
Protein: Protein YIPF1 (YIP1 family member 1) (Q9Y548)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}. Late endosome membrane {ECO:0000269|PubMed:27999994}. Note=Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi. {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}.
Interaction partners:
- F-box only protein 32
- Protein YIPF6
- E3 ubiquitin-protein ligase TRIM63
- Protein YIPF3
- F-box only protein 25
- Protein YIPF4
Sequence:
MAAVDDLQFEEFGNAATSLTANPDATTVNIEDPGETPKHQPGSPRGSGREEDDELLGNDDSDKTELLAGQKKSSPFWTFEYYQTFFDVDTYQVFDRIKGSLLPIPGKNFVRLYIRSNPDLYGPFWICATLVFAIAISGNLSNFLIHLGEKTYHYVPEFRKVSIAATIIYAYAWLVPLALWGFLMWRNSKVMNIVSYSFLEIVCVYGYSLFIYIPTAILWIIPQKAVRWILVMIALGISGSLLAMTFWPAVREDNRRVALATIVTIVLLHMLLSVGCLAYFFDAPEMDHLPTTTATPNQTVAAAKSS
Protein: Putative Lsm7p protein (Q4Q9J1)
Organism: Leishmania major
Interaction partners:
- Probable eukaryotic initiation factor 4A
- U6 snRNA-associated Sm-like protein LSm4
- Small nuclear ribonucleoprotein Sm D2
- Sm domain-containing protein
- Small nuclear ribonucleoprotein E
- Sm protein F
- Small nuclear ribonucleoprotein component-like protein
- Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein
- Sm protein B
- Putative small nuclear ribonucleoprotein
Sequence:
MSAEAAHILKKKEGILSLEKYLDRKIVVSQKGHEVHGVLKGFDNNVNLVLADAELWHRDTHVRKIGACVVRGGPVNLILSGDTTMIPNPFI
Protein: Adhesion G-protein coupled receptor G7 (G-protein coupled receptor 128) (Q96K78)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASCRAWNLRVLVAVVCGLLTGIILGLGIWRIVIRIQRGKSTSSSSTPTEFCRNGGTWENGRCICTEEWKGLRCTIANFCENSTYMGFTFARIPVGRYGPSLQTCGKDTPNAGNPMAVRLCSLSLYGEIELQKVTIGNCNENLETLEKQVKDVTAPLNNISSEVQILTSDANKLTAENITSATRVVGQIFNTSRNASPEAKKVAIVTVSQLLDASEDAFQRVAATANDDALTTLIEQMETYSLSLGNQSVVEPNIAIQSANFSSENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVDGLNPDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQDQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFKKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTSTKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQSEASKVLMLLSSIGRRKSLPSVTRPRLRVKMYNFLRSLPTLHERFRLLETSPSTEEITLSESDNAKESI
Protein: L-lactate dehydrogenase (EC 1.1.1.27) (B5X4K4)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Pyruvate kinase
- Pyruvate carboxylase
- Pyruvate kinase
- Pyruvate kinase
- Probable D-lactate dehydrogenase, mitochondrial
- Malic enzyme
- Malic enzyme
- 2-oxoisovalerate dehydrogenase subunit alpha
- Pyruvate dehydrogenase E1 component subunit beta
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Sequence:
MSSVMQKLLTPVASGPAEPPRNKVTVVGVGMVGMACAVSVLLRDLADELALVDVMEDKLKGELMDLQHGSLFLKTSKIVADKDYAVTANSRIVVVSAGVRQQEGESRLNLVQRNVNIFKHIIPQIVKHSPNCTLIVVSNPVDVLTYVTWKLSGLPKHRVIGSGTNLDSARFRFLMAERLGIHASSFNGWVLGEHGDTSVPVWSGVNVAGVNLQKLNPEFGLDGDKEDWKATHKAVVDSAYEVIKLKGYTNWAIGLSVADLTESIIKNMSRIHPVSTMVKDMYGIGEEVFLSLPCVLNSNGVGSVINMTLTDAEVGQLKKSAETLWGIQKDLKDI
Protein: Biotin transporter BioY (Biotin ECF transporter S component BioY) (A2RMJ9)
Organism: Lactococcus lactis subsp. cremoris (strain MG1363)
Function: Probably a biotin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
Subcellular location: Cell membrane {ECO:0000305|PubMed:21135102}; Multi-pass membrane protein {ECO:0000305|PubMed:21135102}.
Interaction partners:
- Energy-coupling factor transporter transmembrane protein EcfT
- Energy-coupling factor transporter ATP-binding protein EcfA2
- Bifunctional ligase/repressor BirA
- Energy-coupling factor transporter ATP-binding protein EcfA1
- Thiamine transporter ThiT
- biotin--[biotin carboxyl-carrier protein] ligase
- Biotin transporter BioY2
- Riboflavin transporter RibU
- Putative cobalt ABC transporter permease protein
- Sugar ABC transporter substrate-binding protein
Sequence:
MTNNQKVKTLTYSAFMTAFIIILGFLPGIPIGFIPVPIILQNMGIMMAGGLLGPKYGTISVGAFLALALIGLPVLTGGNGGAASFLGPSGGYRIAWLFTPFLIGFFLKKLKITTSQNWFGELIIVLLFGVIFVDFVGAIWLSFQSNIPLLTSLISNLVFIPGDCIKAILTVVIVRRLRKQGGFELYFRK
Protein: Thiol:disulfide interchange protein DsbA (P0AEG4)
Organism: Escherichia coli (strain K12)
Function: Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.
Subcellular location: Periplasm.
Interaction partners:
- Disulfide bond formation protein B
- Thiol:disulfide interchange protein DsbC
- Stress response kinase A
- Thiol:disulfide interchange protein DsbD
- Thiol:disulfide interchange protein DsbE
- Protein YihD
- Chaperone SurA
- Periplasmic serine endoprotease DegP
- Thiol:disulfide interchange protein DsbG
- Alkaline phosphatase
Sequence:
MKKIWLALAGLVLAFSASAAQYEDGKQYTTLEKPVAGAPQVLEFFSFFCPHCYQFEEVLHISDNVKKKLPEGVKMTKYHVNFMGGDLGKDLTQAWAVAMALGVEDKVTVPLFEGVQKTQTIRSASDIRDVFINAGIKGEEYDAAWNSFVVKSLVAQQEKAAADVQLRGVPAMFVNGKYQLNPQGMDTSNMDVFVQQYADTVKYLSEKK
Protein: Large ribosomal subunit protein bL25 (50S ribosomal protein L25) (General stress protein CTC) (P9WHB5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Interaction partners:
- Large ribosomal subunit protein bL9
- Large ribosomal subunit protein uL30
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL21
- Large ribosomal subunit protein bL17
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein bL31
- Large ribosomal subunit protein bL27
Sequence:
MAKSASNQLRVTVRTETGKGASRRARRAGKIPAVLYGHGAEPQHLELPGHDYAAVLRHSGTNAVLTLDIAGKEQLALTKALHIHPIRRTIQHADLLVVRRGEKVVVEVSVVVEGQAGPDTLVTQETNSIEIEAEALSIPEQLTVSIEGAEPGTQLTAGQIALPAGVSLISDPDLLVVNVVKAPTAEELEGEVAGAEEAEEAAVEAGEAEAAGESE
Protein: Syntaxin 16 (B7ZBM4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MALVSGISLDPEAAIGVTKRPPPKWVDGVDEIQYDVGRIKQKMKELASLHDKHLNRPTLDDSSEEEHAIEITTQEITQLFHRCQRAVQALPSRARACSEQEGRLLGNVVASLAQALQELS
Protein: At4g19200 (Proline-rich family protein) (Q9M0L8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT5g45350/MFC19_1
- Cationic amino acid transporter 2
- Protein NCA1
- U3 snoRNP-associated protein-like YAO
Sequence:
MGGGKDKHHDEQEKGFHGFPGGGHYPPAQGGYPPQGYPPQQGYPPAGGYPPAGYPPGAYPAAPGGYPPAPGGYPPAGYPAPGAHHSGHSGGGLGGMIAGAAGAAAAAYGAHHVGHASHNPYGHAVGHGGYGHAPAHGFGHGGHGKFKHGKHGGKFKHGKHGKHGKHGMFGGGGKFKKWK
Protein: Ribonuclease 3-like protein 2 (EC 3.1.26.-) (Ribonuclease III-like protein 2) (RNase III-like protein 2) (Ribonuclease three-like protein 2) (Q9LTQ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ribonuclease that cleaves double-stranded RNA (dsRNA). Required for 3'-external transcribed spacer (ETS) cleavage of the pre-rRNA precursors. May promote the production of 21 nucleotide small interfering RNA (siRNA) during post-transcriptional gene silencing (PTGS).
Subcellular location: Nucleus {ECO:0000269|PubMed:18158302}. Cytoplasm {ECO:0000269|PubMed:18158302}.
Interaction partners:
- Oligoribonuclease
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Thermosome subunit gamma
- Large ribosomal subunit protein mL46
- 50S ribosomal protein L33
- Large ribosomal subunit protein mL43
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein uL23m
- Large ribosomal subunit protein uL13c
- Large ribosomal subunit protein bL34m
Sequence:
MDHSISPEYNFPAITRCSLSNSLPHRPPSPLPSSADIHRFYNSLSPSAPSVPVSSEMESMEAVEKILNYKFSNKSLLKEAITHTSCTDFPSYERLEFIGDSAIGLAISNYLYLTYPSLEPHDLSLLRAANVSTEKLARVSLNHGLYSFLRRNAPSLDEKVKEFSEAVGKEDDLSVSYGGLVKAPKVLADLFESLAGAVYVDVNFDLQRLWVIFRGLLEPIVTLDDLQKQPQPVSMLFKLCHKHKKRIDIKNWKDGNVSIAVIYLDDELLASGRAENKDIARLIAAKEALRKLSEVFPVEMVIDEDSVEIQLTHAKTKLNEICLKKKWPKPIYSVEEDRSSVQGKRFVCSAKIKITEEKTLYMKGDEQSKIKKAESSSAYHMIRALRKSHYL
Protein: Probable tRNA pseudouridine synthase B (EC 5.4.99.25) (tRNA pseudouridine(55) synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) (Q57612)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Interaction partners:
- Ribosome biogenesis protein Nop10
- Large ribosomal subunit protein eL8
- Uncharacterized protein MJ0782.1
- Uncharacterized NOP5 family protein MJ0694
- Probable translation initiation factor IF-2
- tRNA pseudouridine synthase A
- Uncharacterized protein MJ0149
- Cytidylate kinase
- Uncharacterized protein MJ1408
- Uncharacterized GTP-binding protein MJ1464
Sequence:
MILLEKTQEKKINDKEELIVKEEVETNWDYGCNPYERKIEDLIKYGVVVVDKPRGPTSHEVSTWVKKILNLDKAGHGGTLDPKVTGVLPVALERATKTIPMWHIPPKEYVCLMHLHRDASEEDILRVFKEFTGRIYQRPPLKAAVKRRLRIRKIHELELLDKDGKDVLFRVKCQSGTYIRKLCEDIGEALGTSAHMQELRRTKSGCFEEKDAVYLQDLLDAYVFWKEDGDEEELRRVIKPMEYGLRHLKKVVVKDSAVDAICHGADVYVRGIAKLSKGIGKGETVLVETLKGEAVAVGKALMNTKEILNADKGVAVDVERVYMDRGTYPRMWKRKK