wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor TYE7 (Basic-helix-loop-helix protein SGC1) (Ty1-mediated expression protein 7) (P33122)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional activator of glycolytic gene expression, such as enolase genes (ENO1 and ENO2), glyceraldehyde-3-phosphate dehydrogenase gene (TDH), phosphoglycerate kinase (PGK1), phosphoglycerate mutase (PGM1), pyruvate kinase (PYK1) and triosephosphate isomerase (TPI1) genes. Binds DNA on E-box motifs: 5'-CANNTG-3'.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- NPC intracellular sterol transporter 1-related protein 1
- Glycolytic genes transcriptional activator GCR2
- Centromere-binding protein 1
- Glycolytic genes transcriptional activator GCR1
- Ty transcription activator TEC1
Sequence:
MNSILDRNVRSSETTLIKPESEFDNWLSDENDGASHINVNKDSSSVLSASSSTWFEPLENIISSASSSSIGSPIEDQFISSNNEESALFPTDQFFSNPSSYSHSPEVSSSIKREEDDNALSLADFEPASLQLMPNMINTDNNDDSTPLKNEIELNDSFIKTNLDAKETKKRAPRKRLTPFQKQAHNKIEKRYRININTKIARLQQIIPWVASEQTAFEVGDSVKKQDEDGAETAATTPLPSAAATSTKLNKSMILEKAVDYILYLQNNERLYEMEVQRLKSEIDTLKQDQK
Protein: Cationic amino acid transporter 2, vacuolar (Q9ASS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Permease involved in the transport of the cationic amino acids.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:15377779, ECO:0000269|PubMed:17151019}; Multi-pass membrane protein {ECO:0000269|PubMed:15377779, ECO:0000269|PubMed:17151019}.
Interaction partners:
- Catalase-2
- WAT1-related protein At3g28100
- WAT1-related protein At4g15540
- WAT1-related protein At3g28070
- WAT1-related protein At3g28130
- WAT1-related protein At3g28050
- WAT1-related protein At3g28080
- Probable polyamine transporter At1g31820
- At4g19200
- TolB protein-like protein
Sequence:
MGFLVDTQKEGGGHSWGYVRSLVRRKQVDSANGQSHGHQLARALTVPHLVAIGVGATIGAGVYILVGTVAREHSGPSLALSFLIAGIAAGLSAFCYAELSSRCPSAGSAYHYSYICVGEGVAWIIGWALILEYTIGGSAVARGISPNLALIFGGEDGLPAILARHQIPGLDIVVDPCAAILVFVVTGLLCMGIKESTFAQGIVTAVNVCVLLFVIVAGSYLGFKTGWPGYELPTGFFPFGVDGMFAGSATVFFAFIGFDSVASTAEEVRNPQRDLPIGIGLALLLCCSLYMMVSIVIVGLIPYYAMDPDTPISSAFASHDMQWAVYLITLGAVMALCSALMGALLPQPRILMAMARDGLLPSIFSDINKRTQVPVKATVATGLCAATLAFFMDVSQLAGMVSVGTLLAFTMVAISVLILRYVPPDEQPLPSSLQERIDSVSFICGETTSSGHVGTSDSSHQPLIVNNDALVDVPLIKNQEALGCLVLSEETRRIVAGWSIMFTCVGAFLLSYAASSLSFPGLIRYPLCGVGGCLLLAGLIALSSIDQDDARHTFGHSGGYMCPFVPLLPIICILINMYLLVNLGSATWARVSVWLLIGVIVYVFYGRKNSSLANAVYVTTAHAEEIYREHEGSLA
Protein: Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III) (Q03167)
Organism: Homo sapiens (Human)
Function: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19416857, ECO:0000269|PubMed:19726563, ECO:0000269|PubMed:22562249}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:P26342}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P26342}. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix. {ECO:0000250|UniProtKB:P26342}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-2 proprotein
- Transforming growth factor beta-3 proprotein
- TGF-beta receptor type-2
- TGF-beta receptor type-1
- Activin receptor type-2A
- Inhibin alpha chain
- Bone morphogenetic protein 2
- Probable non-functional immunoglobulin heavy variable 3-16
- Immunoglobulin kappa variable 2-28
Sequence:
MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA
Protein: Fanconi anemia group A protein homolog (Protein FACA) (Q9JL70)
Organism: Mus musculus (Mouse)
Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=The major form is nuclear. The minor form is cytoplasmic.
Interaction partners:
- Fanconi anemia, complementation group E
- Fanconi anemia group D2 protein homolog
- Fanconi anemia core complex-associated protein 24
- Fanconi anemia group F protein
- Fanconi anemia group M protein homolog
- Fanconi anemia group G protein homolog
- Fanconi anemia group B protein homolog
- Fanconi anemia core complex-associated protein 100
- E3 ubiquitin-protein ligase FANCL
- Fanconi anemia group C protein homolog
Sequence:
MPGSPARGAAMGGGPRGLRKTWTELLAGRVKKQKYDPEREQKLKDSALKLLRYHQNMHDLLLEVEEPQCKRLRLSELIDRDSADASSDRSASFIRSAFRDQASRLGVPVGVLSAKVFARSVQQVCVEPSHPVLLSPEQSKKLSSLLMIARHLLAQNMFSRLTFCQELWKAQNSLLLEAMWRLHTHSVVSLQELLQSHPDSEAMAMWLFRNLRSLCEQIGASCPSPDTTEAMLSGLVQLLISRGFQGSSDPRRLVEPERLPQVATDVLQRMLAFSLDTLEADPQTTLDCQAVSGWIPIYSGHTCCGVVTENSLKSFFSHTLTQILTHKPVLKVSDAIQMQKEWSFAKTHHLLTDLHCRVLATLGPEESVGRLQEVLEMQEVNWQHVLSCVSTLVVCFPEAQQLVKGWVASLMARAFESYHLDSMVTAFLIVRQATLEGPYVFPSYADWFKESFGSSHGYHSCSKKTLVFLFKFLSDLVPWEAPRYMQVHIFHPPLVPSKYHSLLTDYISLAKTRLADLKVSLENVGLYEDLSSPGDIAERESQAVQDVKKAIMVFEQTGKIPMPVLEASIFRRPYYVSHFLPTLLAPRVLPEVPDPRVALIETLKRADKIPSSIYDAYRKACASAEKQQPENATSAQRTEADCAKEPLGLLTAALEELRALMTDPTQYSVISAQVAVVSEKLNAVLGHRNDGGSLQRAKIQLSVLPSTLQKQDQAVVDLLLTAFCQNLMAASSFVPPERQSPWAVLFVRTLCGHVLLPAVLTRLRQLLRHQGQSLSTSHVLGLAALAVHLGECRSMLPEVDPDVLAPSAGSLCVPDFLNSLLTCRTRDSLLFCMNFCTAAVSYCLCKFSALRNCLSPGLIKKFQFVVLRLFPEARAPCAPEHAACVPWRPLYLPSADWQRAALSLWRRDSFQELLKDKEFYLTYRDWVQLELEIQPEADVLSDMERHDFHQWAIYERYLPAPTALGGCGGDLEEACTVLVSEIMDFHQSSRSYNHSEDSDLVLGGRTGNKDILSRLQEIALDLELDQGSAVPHGCSTPQSHFLFRVFRRRLQALARPDSMATSLRRQQELLTCKRLLLCLPPSVLVGGPQAGQPISPNCGEFFSLVNSELRNFCCHGSVLTSDITIHFFRGLLRVCLRSQDPALVANQTLTECQTKCPVILTSALLWWSSLEPVLCGRWMRCYQSPLPRELRRLQEAREFASNFASASASPAPSPAWIAAAALHFAWRGVRKEDVTAHLQRLDCQREELLIALFFFSLMGLLSSYLTQRDTAEHLKAVDICAEVLTCLERRKVSWLVLFQLTEKDAKLGHLLHLAPDQHTRLLPLAFYSLLSCFSEGAAVREAAFLHVAVDMYLKLLQLFVDGETRLQGHSESQGSPVQLITKARVFLLQLIPQCPKQCFSNMTELLAGRGDCDPEVSNALRQRQQADPSFDLYQEPQLF
Protein: Tetanus toxin (EC 3.4.24.68) (Tentoxylysin) [Cleaved into: Tetanus toxin light chain (Tetanus toxin chain L); Tetanus toxin heavy chain (Tetanus toxin chain H)] (P04958)
Organism: Clostridium tetani (strain Massachusetts / E88)
Function: Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
Interaction partners:
Sequence:
MPITINNFRYSDPVNNDTIIMMEPPYCKGLDIYYKAFKITDRIWIVPERYEFGTKPEDFNPPSSLIEGASEYYDPNYLRTDSDKDRFLQTMVKLFNRIKNNVAGEALLDKIINAIPYLGNSYSLLDKFDTNSNSVSFNLLEQDPSGATTKSAMLTNLIIFGPGPVLNKNEVRGIVLRVDNKNYFPCRDGFGSIMQMAFCPEYVPTFDNVIENITSLTIGKSKYFQDPALLLMHELIHVLHGLYGMQVSSHEIIPSKQEIYMQHTYPISAEELFTFGGQDANLISIDIKNDLYEKTLNDYKAIANKLSQVTSCNDPNIDIDSYKQIYQQKYQFDKDSNGQYIVNEDKFQILYNSIMYGFTEIELGKKFNIKTRLSYFSMNHDPVKIPNLLDDTIYNDTEGFNIESKDLKSEYKGQNMRVNTNAFRNVDGSGLVSKLIGLCKKIIPPTNIRENLYNRTASLTDLGGELCIKIKNEDLTFIAEKNSFSEEPFQDEIVSYNTKNKPLNFNYSLDKIIVDYNLQSKITLPNDRTTPVTKGIPYAPEYKSNAASTIEIHNIDDNTIYQYLYAQKSPTTLQRITMTNSVDDALINSTKIYSYFPSVISKVNQGAQGILFLQWVRDIIDDFTNESSQKTTIDKISDVSTIVPYIGPALNIVKQGYEGNFIGALETTGVVLLLEYIPEITLPVIAALSIAESSTQKEKIIKTIDNFLEKRYEKWIEVYKLVKAKWLGTVNTQFQKRSYQMYRSLEYQVDAIKKIIDYEYKIYSGPDKEQIADEINNLKNKLEEKANKAMININIFMRESSRSFLVNQMINEAKKQLLEFDTQSKNILMQYIKANSKFIGITELKKLESKINKVFSTPIPFSYSKNLDCWVDNEEDIDVILKKSTILNLDINNDIISDISGFNSSVITYPDAQLVPGINGKAIHLVNNESSEVIVHKAMDIEYNDMFNNFTVSFWLRVPKVSASHLEQYGTNEYSIISSMKKHSLSIGSGWSVSLKGNNLIWTLKDSAGEVRQITFRDLPDKFNAYLANKWVFITITNDRLSSANLYINGVLMGSAEITGLGAIREDNNITLKLDRCNNNNQYVSIDKFRIFCKALNPKEIEKLYTSYLSITFLRDFWGNPLRYDTEYYLIPVASSSKDVQLKNITDYMYLTNAPSYTNGKLNIYYRRLYNGLKFIIKRYTPNNEIDSFVKSGDFIKLYVSYNNNEHIVGYPKDGNAFNNLDRILRVGYNAPGIPLYKKMEAVKLRDLKTYSVQLKLYDDKNASLGLVGTHNGQIGNDPNRDILIASNWYFNHLKDKILGCDWYFVPTDEGWTND
Protein: Helix-loop-helix DNA-binding domain containing protein, expressed (Putative DNA binding protein) (Q84LH4)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MYSGQQSDQCPGPNSGKEFLEVNWDSVALHQKMGYNSGAFGFQAYPMVLEDREGLYRSPNGTFCQNIQLSDDHSSGAKRRKGIDDHIALLNPSASSRIQNVGDQQTEVSSQQERISMEEDNQKSCSKMQSKEDSSDGDGTKEDYVHVRAKRGQATNSHSLAERLRRKKISERMKLLQDLVPGCSKITGKAVMLDEIINYVQSLQRQVEFLSMKLATVNPELSFDIEQILSKQMMLSQDRHLAFYGVDPGSSALVAHFNQGIMQPEMLCNVSNPADVLQGTTIQDISTVNQIPAMWEGLQNIPHLNYNPGGAMAEGSTNNSGSMKIEK
Protein: Splicing factor U2af small subunit A (U2 auxiliary factor 35 kDa subunit A) (U2 small nuclear ribonucleoprotein auxiliary factor small subunit A) (U2 snRNP auxiliary factor small subunit A) (Zinc finger CCCH domain-containing protein 8) (AtC3H8) (Q9S709)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Necessary for the splicing of pre-mRNA (By similarity). Probably active at the 3' splice sites.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:16407443, ECO:0000269|PubMed:22563826, ECO:0000269|PubMed:28760995, ECO:0000269|PubMed:36282917}. Note=Colocalizes in nuclear speckles with DRT111/RSN2/SFPS. {ECO:0000269|PubMed:28760995, ECO:0000269|PubMed:36282917}.
Interaction partners:
- Splicing factor U2af large subunit A
- Splicing factor U2af large subunit B
- RNA-binding
- Splicing factor U2af small subunit B
- Nuclear protein-like
- U1 small nuclear ribonucleoprotein 70 kDa
- Zinc finger C-x8-C-x5-C-x3-H type family protein
- Serine/arginine-rich splicing factor SR45
- RNA-binding
- Serine/arginine-rich splicing factor SC35
Sequence:
MAEHLASIFGTEKDRVNCPFYFKIGACRHGDRCSRLHNRPTISPTLLLSNMYQRPDMITPGVDAQGQPLDPRKIQEHFEDFFEDLFEELGKFGEIESLNICDNLADHMIGNVYVQFKEEDQAAAALQALQGRFYSGRPIIADFSPVTDFREATCRQYEENNCNRGGYCNFMHVKLVSRELRRKLFGRYRRSYRRGSRSRSRSRSISPRNKRDNDRRDPSHREFSHRDRDREFYRHGSGKRSSERSERQERDGSRGRRQASPKRGGSPGGGREGSEERRARIEQWNREREEKEEGGA
Protein: ATP-dependent RNA helicase (EC 3.6.4.13) (F6S2B7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVCFCDSHFPRGDNEELHLP
Protein: Actin-depolymerizing factor gmf1 (Glia maturation factor-like protein 1) (O13808)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Actin depolymerizing factor involved in the control of the disassembly of actin patches. Binds and suppresses the arp2/3 complex functions such as the promotion of actin polymerisation and branching filaments.
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, actin patch.
Interaction partners:
- Actin-related protein 2
- Cofilin
- Twinfilin
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 1
- Uncharacterized WD repeat-containing protein C9G1.05
- Actin-related protein 2/3 complex subunit 2
- Protein dip1
Sequence:
MSSEARMFTISDTTMKEIDRFRLRLKKSVMYAFILKVDKATKEIVPDGEIMDLQSIEEVADELSETNPRFILVSYPTKTTDGRLSTPLFMIYWRPSATPNDLSMIYASAKVWFQDVSQVHKVFEARDSEDITSEAVDEFLH
Protein: Aquaporin-3 (AQP-3) (Aquaglyceroporin-3) (Q92482)
Organism: Homo sapiens (Human)
Function: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12239222}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}. Basolateral cell membrane {ECO:0000250|UniProtKB:P47862}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}.
Interaction partners:
- Aquaporin-11
- Putative aquaporin-12A
- Glycerol kinase 2
- Glycerol kinase
- Aquaporin-2
- Aquaporin-8
- Aquaporin-1
- Lens fiber major intrinsic protein
- Aquaporin-5
- Aquaporin-10
Sequence:
MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI
Protein: AFP homolog 2 (Novel interactor of JAZ) (Q9SV55)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a transcriptional repressor. Negative regulator of jasmonate responses. Connects the JAZ proteins and the non-JAZ protein TIFY8 with the TOPLESS corepressors.
Subcellular location: Nucleus {ECO:0000269|PubMed:20360743}.
Interaction partners:
- Protein TOPLESS
- Transcription factor MYC2
- Protein TIFY 10A
- Protein TIFY 9
- Protein TIFY 5A
- Protein TIFY 10B
- Corepressor
- Protein TIFY 11A
- Protein TIFY 6A
- Protein TIFY 6B
Sequence:
MDDDNGLELSLGLSCGGSTGKAKGNNNNNAGSSSENYRAEGGDRSAKVIDDFKNFLHPTSQRPAEPSSGSQRSDSGQQPPQNFFNDLSKAPTTEAEASTKPLWVEDESRKEAGNKRKFGFPGMNDDKKKEKDSSHVDMHEKKTKASHVSTATDEGSTAENEDVAESEVGGGSSSNHAKEVVRPPTDTNIVDNLTGQRRSNHGGSGTEEFTMRNMSYTVPFTVHPQNVVTSMPYSLPTKESGQHAAATSLLQPNANAGNLPIMFGYSPVQLPMLDKDGSGGIVALSQSPFAGRVPSNSATAKGEGKQPVAEEGSSEDASERPTGDNSNLNTAFSFDFSAIKPGMAADVKFGGSGARPNLPWVSTTGSGPHGRTISGVTYRYNANQIKIVCACHGSHMSPEEFVRHASEEYVSPESSMGMTAASAHT
Protein: Carbonic anhydrase 2 (Beta-CA 2) (EC 4.2.1.1) (Carbonate dehydratase 2) (mtCA 2) (P9WPJ9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
Interaction partners:
- Beta-carbonic anhydrase 1
- carbonic anhydrase
- Adenine DNA glycosylase
- Possible siderophore-binding protein
- Adenine phosphoribosyltransferase
- Probable conserved membrane protein
- Probable conserved transmembrane protein
Sequence:
MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV
Protein: Ssz1p (Q5A678)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Zuotin
- Fgr32p
- Hsp90 cochaperone
- Type I HSP40 co-chaperone
- T-complex protein 1 subunit alpha
- Heat shock protein homolog SSE1
- Eukaryotic peptide chain release factor GTP-binding subunit
- CCT-beta
- CCT-theta
- Chaperone ATPase
Sequence:
MSVIGITFGNTSSSIAVASADGKVDVIANPDGDRSIPSALSYIGADEYHGSQAEARLIRNPENTIVNFRDYIGKKFSEINPNTTTGAKPKEINGEISYEITNDGKTEILTVHEVAKRHFKQLKLAAEDFIGKNIEGVVLTVPTDFTEVQRQEIARIAEDAGLKVLQLINEPSAALLAHLSNDEDRLSQDKIYVVADFGGIRTDGAVIAVRGGVLTILATAHEYGLGGDNLDAALSEYFAKEFEKKYKANPRNNARSLAKLKAESIVVKKTLSNVQTSTCSIESLADGFDFHTSINRLRYELTARDPLSKMTAFVEKVIAKADLDPLDIDEVLLVGGAAHTPKLASNISFLFPETTNIIAPSLDSKALNPSELVALGAALQASLVESFDESEIKESLQPIVVNTQHLSKPIGIKDADGNFQPILVAETAYPIKKSIEVTNGDSTSVIVELYEGKRTVKETVIEAEPVEDSEDEDSEEEEPEIKREVVYECGDKLAELSLKDLKPNANLEVIVNITQNGVLHLSGRELKQGSIAVKGEITSQ
Protein: Large ribosomal subunit protein bL12m (39S ribosomal protein L12, mitochondrial) (L12mt) (MRP-L12) (5c5-2) [Cleaved into: Large ribosomal subunit protein bL12m, long mature form; Large ribosomal subunit protein bL12m, short mature form] (P52815)
Organism: Homo sapiens (Human)
Function: As a component of the mitochondrial large ribosomal subunit, it plays a role in mitochondrial translation. Associates with mitochondrial RNA polymerase to activate transcription.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:27184847, ECO:0000269|PubMed:8626705}.
Interaction partners:
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein mL62
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein uL23
Sequence:
MLPAAARPLWGPCLGLRAAAFRLARRQVPCVCAVRHMRSSGHQRCEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLVPMGGVMSGAVPAAAAQEAVEEDIPIAKERTHFTVRLTEAKPVDKVKLIKEIKNYIQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE
Protein: Uncharacterized protein, isoform A (Uncharacterized protein, isoform B) (Q9VMF1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Sugar phosphate phosphatase
Sequence:
MCSIVFDADVVAPPSHLDVPFFEEVLETALRTARVQLLSIHIRMGSSTGENYCSQIYRVKVSFKRPDHPEQHMAFIVKSIPHLDSVEFIDDLQVYLKEKITYYEVLPRLELLMQCNRRFGPKLYHYLKQPENSLVFEDLAEKGFVMASRELGLNEEHCQLVMERLAEFHATSMALAVVDPHIFDAYGDGMLSPRGLAKDDGLLMQFFSGNGKELHHLVSTWPGFEKIAEKIGKYMQNQRANLERSQAPQEKEVKVLNHGDLWVNNMLFKYDGAQRPQDLILIDFQLSVWGSPGIDLNYFFYTSLTLEVLRHRRTQLLRTYHARLAKTLLDLDMGIPVPSYEQILEEVHRRESYGFFASYGIFPTVSQDKAQTADNNLENFKDADFAKQKVRQMFQSRRLADTLRYTLPHFERAGVLD
Protein: NAD(P)-binding Rossmann-fold superfamily protein (Putative cinnamoyl-CoA reductase) (O22809)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable pectate lyase 1
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Defensin-like protein 149
- Putative defensin-like protein 148
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS1z
- AP-4 complex subunit mu
- Small ribosomal subunit protein eS10z
- Small ribosomal subunit protein eS10y
- Small ribosomal subunit protein eS10x
Sequence:
MADVHKGKVCVTGAGGFLGSWVVDLLLSKDYFVHGTVRDPDNEKYAHLKKLEKAGDKLKLFKADLLDYGSLQSAIAGCSGVFHVACPVPPASVPNPEVELIAPAVDGTLNVLKACIEANVKRVVYVSSVAAAFMNPMWSKNQVLDEACWSDQEYCKKTENWYCLAKTRAESEAFEFAKRTGLHLVSVCPTLVLGPILQQNTVNASSLVLLKLLKEGFETRDNQERHLVDVRDVAQALLLVYEKAEAEGRYICTSHTVKEEIVVEKLKSFYPHYNYPKKYIDAEDRVKVSSEKLQKLGWTYRPLEETLVDSVESYRKAKLVD
Protein: NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) (Flavoprotein WrbA) (NAD(P)H:quinone oxidoreductase) (NQO) (P0A8G6)
Organism: Escherichia coli (strain K12)
Function: It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide. It prefers NADH over NADPH.
Interaction partners:
- Uncharacterized protein YccJ
- UPF0759 protein YecE
- HTH-type transcriptional regulator MlrA
- Quinone oxidoreductase 2
- Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
- Fructose-bisphosphate aldolase class 1
- Uncharacterized protein YqjD
- DNA protection during starvation protein
- Potassium binding protein Kbp
- Exodeoxyribonuclease I
Sequence:
MAKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVRGGTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG
Protein: Delta(14)-sterol reductase TM7SF2 (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2) (Q71KT5)
Organism: Mus musculus (Mouse)
Function: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O76062}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:18785926}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Lanosterol 14-alpha demethylase
- Methylsterol monooxygenase 1
- Delta
- 3-beta-hydroxysteroid-Delta
- Lathosterol oxidase
- Squalene monooxygenase
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Delta
- Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
- Ergosterol biosynthetic protein 28 homolog
Sequence:
MTSREASQAPLEFGGPLGVAALLILLPATMFHLLLAARSGPARLLALPAYLPGLEELWSPWALLLLFIWLGLQVALYLLPARKVAEGLELKDKSRLRYPINGFQALVLTALLMGLGVSVGLPLGALPGMLLPLAFATTLTSFIFSLLLYAKALVAPASALAPGGNSGNSMYDFFLGRELNPRLGSFDFKYFCELRPGLIGWVFINLALLMQEAELRGSPSLAMWLVNGFQLLYVGDALWYEESVLTTMDIIHDGFGFMLVFGDLAWVPFTYSLQAQFLLYHPQPLGLPMALLICLLKVIGYYIFRGANSQKNTFRKNPSDPSVAGLETIPTATGRQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGLSHLLPYFYVLYFTALLVHREARDEQQCLQKYGRAWQEYCKRVPYRIIPYVY
Protein: Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) (Q92569)
Organism: Homo sapiens (Human)
Function: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Interaction partners:
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Insulin receptor substrate 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Insulin-like growth factor 1 receptor
- Epidermal growth factor receptor
- Phosphoinositide 3-kinase regulatory subunit 5
Sequence:
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
Protein: SRA stem-loop interacting RNA binding protein (G3V2S9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAASAARGAAALRRSINQPVAFVRRIPWTAASSQLKEHFAQFGHVRRCILPFDKETGFHRGLGWVQFSSEEGLRNALQQENHIIDGVKESLFRDTQWTAKGERPPQANGRKAAQSQPARFTPPK
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit) (Q7Z4X2)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Interaction partners:
Sequence:
MAAESVVAAGLFGLSARRLLAARRRGLPAARVRWESSFSRTVVAPSAVAGKRPPEPTTPWQEDPEPEDENLYEKNPDSHGYDKDPVLDVWNMRLVFFFGVSIILVLGSTFVAYLPDYRMKEWSRREAERLVKYREANGLPIMESNCFDPSKIQLPEDE
Protein: INSIG family protein (Q9Y7R5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Sterol regulatory element-binding protein cleavage-activating protein
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Sequence:
MSRKEIYEPRPRYPDGYNGNRAVKKSLSVLSLDNMKSTLSGLFAPLKLDEEQAEDDESLSSYEDYASRQIDDDLKKQRKKGITFIDYSSLITFFCKLCVIFGLGFVFTYLAEQIVQDAKLPLLTVNLKSWKFEPPWPAIFGFVAVILGLSYRRMDTKYPLGAAPLRPSQSSKWQWISRYLAAFATLLLSMKKLLFISNSHSIVALVASSASIWYIFDRSRNGIILSTITSVLGSILYYNLVDTSKIELNGVEFPEIQFRLWIPMILFSASTIVGNAGRLLF