wanglab/gogpt-training-data huggingface dataset:
Protein: SD04942p (Q8T9D9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDQLAENLEQARLQEGEEEEPLGHDLPEHMLVRNSGTEDAVQPLPQQQQTIDTTGNSQVMAASFMASKTCPYPLSVVWWKTNSGQNRAIIGYSDGSICFVGLSPNCPMIASTAIENGSVMRLVICKDKAYDGVMLLITSSLKQQYKLLLEQKAIKYVYPGDSSPTTREGAWQIVMSVQDKHQSAATGARQSNSSDPASDSSQLEEDVFAPPSSDDVVCSGPAAASSDPSTVSASAEAATADVPPPPAPPSYSEAVARQSGDQGGVRFQQQQLPAGSMDGILPATRARLASLKSLGSKKLQAIKMRLSDQRQKFDEFMPDSTMGSFAIMDSPSVTPEPLGTTSGSFYNIQNLRSTFLLSALHSNSHSLTVHSIDISLKPLFVYKIPKHTQEILISSNILYGIHYVDLHCRSDSDHFTAASLLDDPLVANTEKENRDADIEKIDQADVSAQKSDSTSATTTATSSLDQSDMPSTAINAVSVISSAMASLHTSDEDRFNNLAQLGLFRFENETVLHLYQMAQYRNPSAEPETLTKEEKAKAFELKDIHTPMDYIQFYETADVSSEFSLRQMEIMQSEFPKINYDPSYVITNKNVYTIQLKKEPFELFLDAALQNEFNQCRDFCNTFDLSFEQCIEFAGDYLLRRKKITQALLTYNKARVKPIRTALKLAMYGHTYALMQLSAMALKSTYLLRSRYLGHPLLKGILGDITYRHSEDVRVILPEKHEEEDVNSGVFCSDYHYGVDESISALQMSPSSQFHLANLLLITLAEKAVNDKNYIPLWNFLVTNSKYHTNMTSIVLCQSGLFSSAIILAKIRGVCLDTFNALISVVAQEFGWYNELNVCLYNLSENIFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQRLSKQLNPFSPALRPIVSHNSDCAMSNDNNPQLFEFCKSLIETYLAVLIHMESQRVKYDSIVNALSNFRINYEDNQFAIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNGLYSLGNNNLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAVADGKLYMWGWGIYGQLGQGSCENIATPQLVSFFQI
Protein: Prostate and testis expressed protein 4 (Calcium transport inhibitor) (Caltrin) (PATE-like protein B) (PATE-B) (Seminal vesicle protein 7) (Seminal vesicle protein VII) (SVS VII) (Q09098)
Organism: Mus musculus (Mouse)
Function: Enhances sperm motility. Binds to calmodulin and inhibits calcium transport into spermatozoa. May modulate the function of nicotinic acetylcholine receptors.
Subcellular location: Secreted.
Interaction partners:
- Semenogelin 1
- Seminal vesicle secretory protein 4
- Seminal vesicle secretory protein 3A
- Seminal vesicle secretory protein 6
- Seminal vesicle secretory protein 5
- Amine oxidase
- Prolactin-induced protein
- 9530003J23Rik protein
- Serine protease inhibitor kazal-like protein, minor form
- Prostate and testis expressed protein 3
Sequence:
MNSVTKISTLLIVILSFLCFVEGLICNSCEKSRDSRCTMSQSRCVAKPGESCSTVSHFVGTKHVYSKQMCSPQCKEKQLNTGKKLIYIMCCEKNLCNSF
Protein: Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1) (Q8CBW3)
Organism: Mus musculus (Mouse)
Function: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}.
Interaction partners:
- Nck-associated protein 1-like
- Actin-binding protein WASF2
- Cytoplasmic FMR1-interacting protein 2
- Actin-binding protein WASF1
- Nck-associated protein 1
- Cytoplasmic FMR1-interacting protein 1
- Epidermal growth factor receptor kinase substrate 8
- Protein BRICK1
- Son of sevenless homolog 1
- Actin-binding protein WASF3
Sequence:
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPAAPGAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVAAQFSAQPHVNGGPLYSQNSISVAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD
Protein: P2X purinoceptor 2 (P2X2) (ATP receptor) (Purinergic receptor) (Q8K3P1)
Organism: Mus musculus (Mouse)
Function: Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17706883}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}.
Interaction partners:
- P2X purinoceptor 3
- P2X purinoceptor 6
- P2X purinoceptor 7
- P2X purinoceptor 1
- P2X purinoceptor
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2C
- Neuronal acetylcholine receptor subunit alpha-7
- Glutamate receptor ionotropic, NMDA 2D
- Glutamate receptor ionotropic, NMDA 2A
Sequence:
MAAAQPRLPAGAAMVRRLARGCWSAFWDYETPKVIVVRNRRLGFVHRMVQLLILLYFVWYVFIVQKSYQDSETGPESSIITKVKGITMSEHKVWDVEEYVKPPEGGSVVSIITRIEVTPSQTLGTCPESMRVHSSTCHLDDDCVAGQLDMQGNGIRTGRCVPYYHGDSKTCEVSAWCPVEDGTSENHFLGKMAPNFTILIKNSIHYPKFKFSKGNIASQKSDYLKHCTFDQDSDPYCPIFRLGFIVEQAGENFTELAHKGGVIGVIINWNCDLDLSESECNPKYSFRRLDPKYDPASSGYNFRFAKYYKINGTTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKLYSHKKFDKVRTPRHPSSRWPVTLALVLGQIPPPPSHYSQDQPPSLPSGEGPALGEGAELPLAVQPPRSCSSSALTEQVVDTLDQHMGQRPPVPEPSQQDSTSTDPKGLAQL
Protein: DNA-directed RNA polymerase subunit beta' (EC 2.7.7.6) (PEP) (Plastid-encoded RNA polymerase subunit beta') (RNA polymerase subunit beta') (P56763)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular location: Plastid, chloroplast {ECO:0000255|HAMAP-Rule:MF_01323}.
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit beta''
- DNA-directed RNA polymerase subunit alpha
- ATP synthase subunit b, chloroplastic
- Small ribosomal subunit protein bS16cz
- Large ribosomal subunit protein uL2cz/uL2cy
- Large ribosomal subunit protein uL2mz, N-terminal part
- Ribosomal protein L2.
- Large ribosomal subunit protein uL2z
- Large ribosomal subunit protein uL16m
Sequence:
MIDRYKHQQLRIGLVSPQQISAWATKIIPNGEIVGEVTKPYTFHYKTNKPEKDGLFCERIFGPIKSGICACGNYRVIGDEKEDPKFCEQCGVEFVDSRIRRYQMGYIKLTCPVTHVWYLKRLPSYIANLLDKPLKELEGLVYCDFSFARPITKKPTFLRLRGSFEYEIQSWKYSIPLFFTTQGFDIFRNREISTGAGAIREQLADLDLRIIIENSLVEWKQLGEEGPTGNEWEDRKIVRRKDFLVRRMELAKHFIRTNIEPEWMVLCLLPVLPPELRPIIQIEGGKLMSSDINELYRRVIYRNNTLTDLLTTSRSTPGELVMCQEKLVQEAVDTLLDNGIRGQPMRDGHNKVYKSFSDVIEGKEGRFRETLLGKRVDYSGRSVIVVGPSLSLHRCGLPREIAIELFQTFVIRGLIRQHLASNIGVAKSQIREKKPIVWEILQEVMQGHPVLLNRAPTLHRLGIQSFQPILVEGRTICLHPLVCKGFNADFDGDQMAVHVPLSLEAQAEARLLMFSHMNLLSPAIGDPISVPTQDMLIGLYVLTSGTRRGICANRYNPCNRKNYQNERIYETNYKYTKEPFFCNSYDAIGAYRQKKINLDSPLWLRWQLDQRVIASREVPIEVHYESFGNYHEIYAHYLIVRSVKKENFCIYIRTTVGHISFYREIEEAIQGFSQACSYDT
Protein: Major capsid protein (MCP) (P0C703)
Organism: Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Function: Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04016}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04016}.
Interaction partners:
Sequence:
MASNEGVENRPFPYLTVDADLLSNLRQSAAEGLFHSFDLLVGKDAREAGIKFEVLLGVYTNAIQYVRFLETALAVSCVNTEFKDLSRMTDGKIQFRISVPTIAHGDGRRPSKQRTFIVVKNCHKHHISTEMELSMLDLEILHSIPETPVEYAEYVGAVKTVASALQFGVDALERGLINTVLSVKLRHAPPMFILQTLADPTFTERGFSKTVKSDLIAMFKRHLLEHSFFLDRAENMGSGFSQYVRSRLSEMVAAVSGESVLKGVSTYTTAKGGEPVGGVFIVTDNVLRQLLTFLGEEADNQIMGPSSYASFVVRGENLVTAVSYGRVMRTFEHFMARIVDSPEKAGSTKSDLPAVAAGVEDQPRVPISAAVIKLGNHAVAVESLQKMYNDTQSPYPLNRRMQYSYYFPVGLFMPNPKYTTSAAIKMLDNPTQQLPVEAWIVNKNNLLLAFNLQNALKVLCHPRLHTPAHTLNSLNAAPAPRDRRETYSLQHRRPNHMNVLVIVDEFYDNKYAAPVTDIALKCGLPTEDFLHPSNYDLLRLELHPLYDIYIGRDAGERARHRAVHRLMVGNLPTPLAPAAFQEARGQQFETATSLAHVVDQAVIETVQDTAYDTAYPAFFYVVEAMIHGFEEKFVMNVPLVSLCINTYWERAGRLAFVNSFSMIKFICRHLGNNAISKEAYSMYRKIYGELIALEQALMRLAGSDVVGDESVGQYVCALLDPNLLPPVAYTDIFTHLLTVSDRAPQIIIGNEVYADTLAAPQFIERVGNMDEMAAQFVALYGYRVNGDHDHDFRLHLGPYVDEGHADVLEKIFYYVFLPTCTNAHMCGLGVDFQHVAQTLAYNGPAFSHHFTRDEDILDNLENGTLRDLLEISDLRPTVGMIRDLSASFMTCPTFTRTVRVSVDNDVTQQLAPNPADKRTEQTVLVNGLVAFAFSERTRAVTQCLFHAIPFHMFYGDPRVAATMHQDVATFVMRNPQQRAVEAFNRPEQLFAEYREWHRSPMGKYAAECLPSLVSISGMTAMHIKMSPMAYIAQAKLKIHPGVAMTVVRTDEILSENILFSSRASTSMFIGTPNVSRREARVDAVTFEVHHEMASIDTGLSYSSTMTPARVAAITTDMGIHTQDFFSVFPAEAFGNQQVNDYIKAKVGAQRNGTLLRDPRTYLAGMTNVNGAPGLCHGQQATCEIIVTPVTADVAYFQKSNSPRGRAACVVSCENYNQEVAEGLIYDHSRPDAAYEYRSTVNPWASQLGSLGDIMYNSSYRQTAVPGLYSPCRAFFNKEELLRNNRGLYNMVNEYSQRLGGHPATSNTEVQFVVIAGTDVFLEQPCSFLQEAFPALSASSRALIDEFMSVKQTHAPIHYGHYIIEEVAPVRRILKFGNKVVF
Protein: Vitamin D3 receptor (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) (A0A5K1VW50)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEISXLGQPVAVPGWGCSSRATCQARGWRLLSSPPHPVWGSAPPLPPPLSTQPILSPVQPNPFPAGFSPVP
Protein: LIM zinc-binding domain-containing protein (H2KZV8)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- GEX Interacting protein
- Uncharacterized protein F15G9.1
Sequence:
MPFKPVEHPKCPKCGKSVYAAEEMSAGGYKWHKFCFKCNMCNKLLDSCTVAPHEAELYCKQCHGRKFGPKGVGFGLGAGCLTTDSGEKFGGSKQTNRPMTAEAFTAPINPSHS
Protein: Uncharacterized protein YhiI (P37626)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Ribosome-associated ATPase
- Inner membrane transport permease YhhJ
- Probable multidrug ABC transporter permease YbhS
- Macrolide export ATP-binding/permease protein MacB
- Probable multidrug ABC transporter ATP-binding protein YbhF
- Probable multidrug ABC transporter permease YbhR
Sequence:
MDKSKRHLAWWVVGLLAVAAIVAWWLLRPAGVPEGFAVSNGRIEATEVDIASKIAGRIDTILVKEGKFVREGEVLAKMDTRVLQEQRLEAIAQIKEAQSAVAAAQALLEQRQSETRAAQSLVNQRQAELDSVAKRHTRSRSLAQRGAISAQQLDDDRAAAESARAALESAKAQVSASKAAIEAARTNIIQAQTRVEAAQATERRIAADIDDSELKAPRDGRVQYRVAEPGEVLAAGGRVLNMVDLSDVYMTFFLPTEQAGTLKLGGEARLILDAAPDLRIPATISFVASVAQFTPKTVETSDERLKLMFRVKARIPPELLQQHLEYVKTGLPGVAWVRVNEELPWPDDLVVRLPQ
Protein: Ankyrin repeat domain-containing protein 31 (A0A140LI88)
Organism: Mus musculus (Mouse)
Function: Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes.
Subcellular location: Nucleus {ECO:0000269|PubMed:31000436}. Chromosome {ECO:0000269|PubMed:31000436, ECO:0000269|PubMed:31003867}. Note=Localizes on chromatin between preleptotene and early pachytene (PubMed:31000436). Associates with the chromosome axes, but disappears from axes upon synaptonemal complex formation (PubMed:31000436). {ECO:0000269|PubMed:31000436}.
Interaction partners:
- Meiotic recombination protein REC114
- Interactor of HORMAD1 protein 1
- Meiosis inhibitor protein 1
- Type 2 DNA topoisomerase 6 subunit B-like
Sequence:
MENGAEASDCDSDETVIEGSVTENEPEDEELPWRRLLLNQDTTCRSEFCFHSGVDGMQKGIHSPEIQLGLKLRKDSQEQNNKNKLLLALSEDLVLQDPQDKTAQNQVLLQTTKEFPVFTVSFPHPEVSWSHQNTGGHEAENCENLPHSKKELRENSDSPEVSLLSGTSPVAPDLVALKERLTEPVKTLAVPNTLSEPGEEVTQTMTSKETKDEESSLETFVSTLEKLLESSECTQEERLLEVMDDFNPQELFSTLSNSLGSVSVPLNAWAAQGRDELENKADAALPAKLLAAVNTGADVGPSCQGQEKSSSVSGGNGCLAVQPIMSQVDEDCTQIAQNIEDPKPFRLQTLTHENAISYEQINKKKNSDPIKNTSTQETPRVLRRSSRLEKLKASRDVVHTEAVLKKPERILSNTLSFKDQINSIFTTDSFSKRKNMHSSGFKNEQIRKSEQLRKKNGTGEMKKMCLCTINRRNVFGENLLYKAALHNDVDLVRCCIKNGENVNQPSYDGWTALHEASIGGYYQAVSELLKGGADVNVKGKYQITPLHDAVMNRHYKVAELLLMSGADPLFRSDHGTCALDEAKDSSMETLLMKYIPQQKKCHLSAQRNSTDPAHVEDMFQNKKPKLSSNNYTEFICDENFDRQEPGHLEINKGSNNLLMSKEYVCEHCQKDSNTTKFGKSNLNSVKNSRTNVSKRKGQKNRQQKKTQVDDRDCNLSQKIGTSSFRRTNKLLTQQQHAVQTLSDLPEESFELSTTTLSSLENGIGYNEACLVSKKSDTHVLDSSDGQELESVDQTEAASVSELSSYKEIKLLPVTTHQQPHTNQEQYSSPYKSLGNNSSNEKGKATNKWEDSFFSFIKGRSADSDSDCHTLDKSIASPKEGMSHDHHEEIMTGQEVDSQQRLSSENYFSQENDLKVHPLTTHPQEEAVNFCDSNLISVQHTPDYKNCLHEISFGNSYAKTEQSSTSCTRPPSTQKVSPLTVEVELLKGLQDSLAHRDSSPLVNQAGIHSLERKQDTDKNYTKKGPNTSSSSRPLPTVVHSQVIEITKAEKRREDLPGNEPINNTDFYSTDINKELANSSQLNQRKEKENVRKSDAELTHNDSEAERTLKSCEEKKKNMDSETHSPCDIQEHRKDQNFRKRKCSLKAPCSQGVNTTGIGKRNKKGESQLHVAARGGNLSRVKVLIEARADVNLRDNAGWTPLHKAASGGFDDVIIELLQAGANVNCENIDGIVPLHGASAGNHLKAAEILLEHGANPNQKDQKQRTALDEADDEKMKELLKSYGAIESTNGEKRNSTDLVKIPTVQPKRYKQFICDNDKAIGSPVPSHKAKKSESLPVHQTISAILQDIEEKQENLLKLEIRNSEDEEQYIGKMLEIKEVMDNILAQQKTERDDLAKKYRVSMESFKHGALREQLANLATRQKSLLVVAKKQKKIRLKIQNYKNATAVSGVGLRKLPCNSDISSDKKSQEPPTMGDSAHAQPGLLAPVSLAYGSMQEIPLSPEIESESQKINICLNAEAIRREEFSGNDINSKQNVQDCTLGGLLRSKPTDDAEKIASSSQPAALTPHAENSQAEATVKGCGFDSSALTGTINISEDKSIFSPNGACLAADPHSQKLSRCNPKRRNKKTASQQPSAGAAEPLPQAPAVLDTYTVHQTLPCLRDSAAAASHTDSTQSSLSSASAHQHPTKTVPHRNTTPRKKAVQLKDLILRGRINPGNNILEFKTQETTHRASVLPSGKLKGENGQIYQNPVTWLKELLGGGSYVTWNYAWNTVTYLGRELVKCVSEEAPMSAELNPPQLHQPHLSAGTSRESMQTIPHYLQIKEILQISKQELLPCHVMEQHWKFYVGRSHSEALLSW
Protein: DENN domain-containing protein 4C (A6H8H2)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21454697}. Cell membrane {ECO:0000269|PubMed:21454697}. Cytoplasm, cytosol {ECO:0000269|PubMed:21454697}. Note=Associates with SLC2A4/GLUT4 storage vesicles.
Interaction partners:
- DENN domain-containing protein 5A
- Vacuolar protein sorting-associated protein 26A
- Vacuolar protein sorting-associated protein 26B
- Vacuolar protein sorting-associated protein 35
- Vacuolar protein sorting-associated protein 29
- Rabankyrin-5
- Sorting nexin-2
- TBC1 domain family member 5
- Ras-related protein Rab-7a
- Ras-related protein Rab-10
Sequence:
MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRTDTNSIGPKAPITDIAVIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYRRGRDKPPLTDIGVLYEGKERLMPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPPVRSQNSLAVTDICVIITSKGETPPHTFCKVDKNLNCGMWGSNVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSPSVPLFCLPMGATIECWDPQIKYPLPVFSTFVLTGSSAEKVYGAAIQFYEPYSQERLTEKQLTQLGLLTLVEKRVVSKPINSNKCICLLSHWPFFEAFKNFLMFIYKVSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILIQLSVHDAFILSQPVSTPLPLSGANFSSLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAGVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNTLYVADERKNINWKQLPKRPCKSLLGTLRRLYQQLCSVHRKPQESSAIEMTPIEADYSWQKKMTQLEMEIQETFLRFMASILKGYRSYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGVERTEKVDLDSAEDTRLIELDDSQRSEHTVFIMPPEPPPDDGNNLSPQYSYTYFPRLDLKLFDSPQKLKLCFNRHPPGSSITNSPALMAKRTKQEIKTAHKLAKRCYTNPPQWAKYLFSHCYSLWFICLPAYVRVSHPKVRALQQAHDVLVKMRKTDVDPLDEVCYRVVMQLCGLWVNPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVHGLAQFRQPLKKTGQKSQVFSISGGQSDQGYGSKDELVKEGADGHAPEEHTPPELTTTELHIEEECDISAIVSKHLQPTPEPQSPTEPPAWGSSIVKVPSGLFDTNNRTSTGSTSTVLFSTQAPVEDAVFSEVTNFKKNGDRGEKKQKHFPERSCSFSSESRAGMLLKKSSLDLNSSEMAIMMGADAKILTAALTCPKTSPPHVTRTHSFENVNCHLADSRTRMSEGTRDSEHRSSPVLEMLEESQELLEPVVGDNVAETAAEMTCNSLQSNSHSDQSRDTQAGAQDPVNKRSSSYATRKAIEREDVETGLDPLSLLATECVEKTSDSEDKLFSPVISRNLADEIESYMNLKSPLGSKSCSMELHGEGNQEPGSPAVFAHPLERSSSLPSDRGPPARDSTETEKSSPAVSSSKTLTGRFKPQSPYRAYKDRSTSLSALVRSSPNSSLGSVVNSLSGLKLDNILSGPKIDVLKSSMKQAATVASKMWVAVASAYSYSDDEEETNKDYSFPAGLEDHHIVGETLSPNTSVSGLVPSELTQSNTSLGSSSSSGDVGKLQCPAGEVPFSRNIKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTTCPFCKSNFLPLLNVEFKDLRGSASFFLKPSTSGDSLQSGSIPSASEPSEHKPTSSSAEPDLISFMDFSKHSETITEEASYTVESSDEIKKTNGDVQSVKMSSVPNSLSKRNVSLTRSHSVGGPLQNIDFSQRPFHGVSTVSLPSSLQEDVDHLGKRPSPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNGGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPGEPLYVSWRNLNSEKKPSLLSEQQQAASALVETIRQSIQQNDVLKPINLLSQQMKPGTKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGLAYRSLPSESLERLQRIDAPPSISVEWCRKCFGAPLI
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Q8MSP3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLCRNYGRIKKSIDNISKSKIPNPHNPYVEHRNRTIHSSQGHTLANGYAMGDPRSSRCHDKLFSGSLKSLARREDSNASDSEGTDTAKGSGTGLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIAEQSARRCKPGGLAKSYRRLMQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEELTEQVSMLPQTQNQPQYQSLQQQQPSETDDENDDEAAPASLSHASESEYDTCESSMSERSAEVLLKTEYFVTPCRTNGSNSGLPEGHSVQLQQAPLQHQQKNVSSAEQKPIEAARSIISDVFDGKLLSSVQCLTCDRVSTREETFQDLSLPIPNRDFLNVLHQTHSLSVQSLNAAETSARTNEGWLSWMWNMLRSWIYGPSVTLYDCMASFFSADELKGDNMYSCERCNKLRTGIKYSRVLTLPEVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYIHKDCKSEVAIYNLSSVICHHGTVGGGHYTCFARNALNGKWYEFDDQFVTEVSSELVQSCQAYVLFYHKHNPQMKLVRDEAMTLSTSHPLCDSDIQFYITREWLSRLATFSEPGPINNQEMLCPHGGILHSKADVISQIAVPISQPLWDYLYRTFGGGPAVNIIFECEICKRAAETLSRRQQYELNEFTKYNGLQNEFDSTAIYAIAMPWLRSWQQFSRGKTHKDPGPITNEGIAAPTENGSATVSCVRLGSDYAQLNARLWRFLHNIYGGGPEIILRQALSDEDDAEEIEIIDQDDECDDDEDQDLEGEGEDEEIAAASYQHNHSDTESNLGIRNTPSPSPSTSPSPSLTGTRQPMETESDLRPSSSKSKRSRSKMKVSALRLNMRNRGKRNRSAFKQYAEMFGAKGNYNAHSNAEPVVSEKDEKDKDNDRTVAFPSEYSLPISIPFQSDNFQVNGVHEKSRDKGKLRNSSKSGSTAATKENVTLQKFVTLREANGPSDETDI
Protein: Large ribosomal subunit protein P1y (60S acidic ribosomal protein P1-3) (Q8LEQ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays an important role in the elongation step of protein synthesis.
Interaction partners:
- Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein uL10z
- Large ribosomal subunit protein eL24y
- Large ribosomal subunit protein eL24z
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein uL24z
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein uL10y
Sequence:
MSTVGELACSYAVMILEDEGIAITADKIATLVKAAGVTIESYWPMLFAKMAEKRNVTDLIMNVGAGGGGGAPVAAAAPAAGGGAAAAAPAAEEKKKDEPAEESDGDLGFGLFD
Protein: Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) (O60282)
Organism: Homo sapiens (Human)
Function: Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission. Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:24812067}. Note=Abundant in distal regions of dendrites. {ECO:0000269|PubMed:24812067}.
Interaction partners:
- Kinesin light chain 1
- Kinesin light chain 2
- Kinesin light chain 4
- Kinesin light chain 3
- E3 SUMO-protein ligase RanBP2
- Tubulin beta-2B chain
- Kinesin heavy chain isoform 5A
- Tubulin alpha-1A chain
- Kinesin-1 heavy chain
- Casein kinase II subunit alpha'
Sequence:
MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNSTHYQK
Protein: PQ loop repeat protein (Q5ADX1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MANAVAENVLGTIGTVLWCIQLIPQVIRNYRAKNCEGLPPLMMFLWAASGVPFSIYFIATDGSIPLRIQPQLFTFFCTLSWIQTLYYPPKKVSRTRLVTFVGAFIAISIGLEVGFILWLRPLYRRGIEWPMLIIGIVASILLAIGLIPPYFELAKRQGRVIGINFVFLTLDSLGALFSLLSIVVGTMDIMSIVLYAIVLALEVGIFASHFIWWLRIGRNSDNESVDVQRHHETHSNDEEKSEVVVV
Protein: Metallothionein-like protein 1C (MT-1C) (Q38804)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Confers tolerance to cadmium (Cd) and plays a role in Cd and zinc (Zn) homeostasis.
Interaction partners:
- Metallothionein-like protein 2B
- Glutathione gamma-glutamylcysteinyltransferase 1
- Metallothionein-like protein 4A
- Metallothionein-like protein 4B
- Metallothionein-like protein 2A
- Protein ECS1
- Uncharacterized protein AT4g11020
- Protein NIM1-INTERACTING 3
- Protein DUF642 L-GALACTONO-1,4-LACTONE-RESPONSIVE GENE 2
Sequence:
MAGSNCGCGSSCKCGDSCSCEKNYNKECDNCSCGSNCSCGSSCNC
Protein: Homeobox protein Hox-C6 (Homeobox protein Hox-3.3) (Homeobox protein Hox-6.1) (P10629)
Organism: Mus musculus (Mouse)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-C9
- Homeobox protein Hox-C5
- Homeobox protein Hox-B7
- Homeobox protein Hox-C4
- Homeobox protein Hox-A7
- Homeobox protein Hox-D4
- Homeobox protein Hox-B6
- Homeobox protein Hox-B5
Sequence:
MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAVAQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE