Protein: Histone-lysine N-methyltransferase ATXR3 (EC 2.1.1.354) (Protein SET DOMAIN GROUP 2) (Trithorax-related protein 3) (TRX-related protein 3) (O23372)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone methyltransferase specifically required for trimethylation of 'Lys-4' of histone H3 (H3K4me3) and is crucial for both sporophyte and gametophyte development. Function as a diurnal 'writer' to counteract the nocturne 'eraser' demethylase activity of JMJ14 thus orchestrating the circadian rythm of histone modifications (e.g. H3K4me3) and modulating the rythmic expression of diurnal target genes; this mechanism relies also on the circadian clock oscillators CCA1 and LHY.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Histone H3-like centromeric protein CENH3
- Histone H3.3
- Histone H3-like 2
- Histone H3-like 5
- Histone H3.1
- Histone H3-like 3
- Histone H3-like 4
- Histone H3-like 1
- Histone-lysine N-methyltransferase CLF
- Protein TRAUCO
Sequence:
MSDGGVACMPLLNIMEKLPIVEKTTLCGGNESKTAATTENGHTSIATKVPESQPANKPSASSQPVKKKRIVKVIRKVVKRRPKQPQKQADEQLKDQPPSQVVQLPAESQLQIKEQDKKSEFKGGTSGVKEVENGGDSGFKDEVEEGELGTLKLHEDLENGEISPVKSLQKSEIEKGEIVGESWKKDEPTKGEFSHLKYHKGYVERRDFSADKNWKGGKEEREFRSWRDPSDEIEKGEFIPDRWQKMDTGKDDHSYIRSRRNGVDREKTWKYEYEYERTPPGGRFVNEDIYHQREFRSGLDRTTRISSKIVIEENLHKNEYNNSSNFVKEYSSTGNRLKRHGAEPDSIERKHSYADYGDYGSSKCRKLSDDCSRSLHSDHYSQHSAERLYRDSYPSKNSSLEKYPRKHQDASFPAKAFSDKHGHSPSRSDWSPHDRSRYHENRDRSPYARERSPYIFEKSSHARKRSPRDRRHHDYRRSPSYSEWSPHDRSRPSDRRDYIPNFMEDTQSDRNRRNGHREISRKSGVRERRDCQTGTELEIKHKYKESNGKESTSSSKELQGKNILYNNSLLVEKNSVCDSSKIPVPCATGKEPVQVGEAPTEELPSMEVDMDICDTPPHEPMASDSSLGKWFYLDYYGTEHGPARLSDLKALMEQGILFSDHMIKHSDNNRWLVNPPEAPGNLLEDIADTTEAVCIEQGAGDSLPELVSVRTLPDGKEIFVENREDFQIDMRVENLLDGRTITPGREFETLGEALKVNVEFEETRRCVTSEGVVGMFRPMKRAIEEFKSDDAYGSESDEIGSWFSGRWSCKGGDWIRQDEASQDRYYKKKIVLNDGFPLCLMQKSGHEDPRWHHKDDLYYPLSSSRLELPLWAFSVVDERNQTRGVKASLLSVVRLNSLVVNDQVPPIPDPRAKVRSKERCPSRPARPSPASSDSKRESVESHSQSTASTGQDSQGLWKTDTSVNTPRDRLCTVDDLQLHIGDWFYTDGAGQEQGPLSFSELQKLVEKGFIKSHSSVFRKSDKIWVPVTSITKSPETIAMLRGKTPALPSACQGLVVSETQDFKYSEMDTSLNSFHGVHPQFLGYFRGKLHQLVMKTFKSRDFSAAINDVVDSWIHARQPKKESEKYMYQSSELNSCYTKRARLMAGESGEDSEMEDTQMFQKDELTFEDLCGDLTFNIEGNRSAGTVGIYWGLLDGHALARVFHMLRYDVKSLAFASMTCRHWKATINSYKDISRQVDLSSLGPSCTDSRLRSIMNTYNKEKIDSIILVGCTNVTASMLEEILRLHPRISSVDITGCSQFGDLTVNYKNVSWLRCQNTRSGELHSRIRSLKQTTDVAKSKGLGGDTDDFGNLKDYFDRVEKRDSANQLFRRSLYKRSKLYDARRSSAILSRDARIRRWAIKKSEHGYKRVEEFLASSLRGIMKQNTFDFFALKVSQIEEKMKNGYYVSHGLRSVKEDISRMCREAIKDELMKSWQDGSGLSSATKYNKKLSKTVAEKKYMSRTSDTFGVNGASDYGEYASDREIKRRLSKLNRKSFSSESDTSSELSDNGKSDNYSSASASESESDIRSEGRSQDLRIEKYFTADDSFDSVTEEREWGARMTKASLVPPVTRKYEVIEKYAIVADEEEVQRKMRVSLPEDYGEKLNAQRNGIEELDMELPEVKEYKPRKLLGDEVLEQEVYGIDPYTHNLLLDSMPGELDWSLQDKHSFIEDVVLRTLNRQVRLFTGSGSTPMVFPLRPVIEELKESAREECDIRTMKMCQGVLKEIESRSDDKYVSYRKGLGVVCNKEGGFGEEDFVVEFLGEVYPVWKWFEKQDGIRSLQENKTDPAPEFYNIYLERPKGDADGYDLVVVDAMHMANYASRICHSCRPNCEAKVTAVDGHYQIGIYSVRAIEYGEEITFDYNSVTESKEEYEASVCLCGSQVCRGSYLNLTGEGAFQKVLKDWHGLLERHRLMLEACVLNSVSEEDYLELGRAGLGSCLLGGLPDWMIAYSARLVRFINFERTKLPEEILKHNLEEKRKYFSDIHLDVEKSDAEVQAEGVYNQRLQNLAVTLDKVRYVMRHVFGDPKNAPPPLERLTPEETVSFVWNGDGSLVDELLQSLSPHLEEGPLNELRSKIHGHDPSGSADVLKELQRSLLWLRDEIRDLPCTYKCRNDAAADLIHIYAYTKCFFKVREYQSFISSPVHISPLDLGAKYADKLGESIKEYRKTYGENYCLGQLIYWYNQTNTDPDLTLVKATRGCLSLPDVASFYAKAQKPSKHRVYGPKTVKTMVSQMSKQPQRPWPKDKIWTFKSTPRVFGSPMFDAVLNNSSSLDRELLQWLRNRRHVFQATWDS