wanglab/gogpt-training-data huggingface dataset:
Protein: Potassium voltage-gated channel subfamily A member 4 (RCK4) (RHK1) (RK3) (Voltage-gated potassium channel subunit Kv1.4) (P15385)
Organism: Rattus norvegicus (Rat)
Function: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure. Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10896669, ECO:0000269|PubMed:2348860, ECO:0000269|PubMed:2384173}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:10896669, ECO:0000269|PubMed:1497894, ECO:0000305|PubMed:8361540}.
Interaction partners:
- A-type potassium channel modulatory protein KCNIP1
- A-type potassium channel modulatory protein KCNIP2
- Potassium voltage-gated channel subfamily A member 1
- Disks large homolog 4
- Calsenilin
- Voltage-gated potassium channel subunit beta-1
- A-type potassium channel modulatory protein DPP6
- Voltage-gated potassium channel subunit beta-2
- Inactive dipeptidyl peptidase 10
- Kv channel-interacting protein 4
Sequence:
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGTGGSGGGPHHHHQTRGAYSSHDPQGSRGSREEEATRTEKKKKLHHRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEEDHGDGCSYTDLLPQDDGGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCGKEEKCQGKGDDSETDKNNCSNAKAVETDV
Protein: Monocarboxylate transporter 6 (MCT 6) (Monocarboxylate transporter 5) (MCT 5) (Solute carrier family 16 member 5) (O15375)
Organism: Homo sapiens (Human)
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MPQALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHNTGYCVYILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMGGSFYALQKKEQGKQAVAADALERDLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWGCPASSRTSHEWLLWPKAVLQAKQTALGWNSPT
Protein: Type I iodothyronine deiodinase (EC 1.21.99.3) (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase) (P24389)
Organism: Rattus norvegicus (Rat)
Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11089566}; Single-pass type III membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:7744884}; Single-pass type III membrane protein {ECO:0000305|PubMed:7744884}. Basolateral cell membrane {ECO:0000269|PubMed:2040632}; Single-pass type III membrane protein {ECO:0000305|PubMed:2040632}.
Interaction partners:
- Type II iodothyronine deiodinase
- Selenoprotein P
- Thyroid hormone receptor alpha
Sequence:
MGLSQLWLWLKRLVIFLQVALEVATGKVLMTLFPERVKQNILAMGQKTGMTRNPRFAPDNWVPTFFSIQYFWFVLKVRWQRLEDRAEYGGLAPNCTVVRLSGQKCNVWDFIQGSRPLVLNFGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNNVDIRQHRSLQDRLRAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKPGPWNYNPEEVRAVLEKLCIPPGHMPQF
Protein: Accumulation of dyads protein 2 (Ammonia transport outward protein 1) (P25613)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transporter protein required for ammonia export and acetate uptake and resistance. Necessary for up-regulation and down-regulation of meiotic plaque (MP) component levels in a dependency on external acetate. Has a role in ascus formation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16286509, ECO:0000269|PubMed:17395151}; Multi-pass membrane protein {ECO:0000269|PubMed:16286509, ECO:0000269|PubMed:17395151}. Vacuole membrane {ECO:0000269|PubMed:16286509}; Multi-pass membrane protein {ECO:0000269|PubMed:16286509}. Note=Localizes to large detergent resistant patches of the cell membrane (DRM) enriched in ergosterol and sphingolipids (PubMed:17395151).
Interaction partners:
- Carboxylic acid transporter protein homolog
- Acetyl-coenzyme A synthetase 1
- Alcohol dehydrogenase 2
- Citrate synthase 3, mitochondrial
Sequence:
MSDKEQTSGNTDLENAPAGYYSSHDNDVNGVAEDERPSHDSLGKIYTGGDNNEYIYIGRQKFLKSDLYQAFGGTLNPGLAPAPVHKFANPAPLGLSAFALTTFVLSMFNARAQGITVPNVVVGCAMFYGGLVQLIAGIWEIALENTFGGTALCSYGGFWLSFAAIYIPWFGILEAYEDNESDLNNALGFYLLGWAIFTFGLTVCTMKSTVMFFLLFFLLALTFLLLSIGHFANRLGVTRAGGVLGVVVAFIAWYNAYAGVATKQNSYVLARPFPLPSTERVIF
Protein: Putative G1 cyclin CycE4 (Q8I8A9)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MTLSVDTAIGDTAICMERSCDAPTPTYAVKTRAMVLSGGSGCTLSRCRRLGRSARQRSPSNKRFSGRMSAASVTPSGGPVMDRSGTGYVDVCRGGECAPMLCRSGGCDHGVSIFAAAATPAAAVPLLDGTVAAECTNGAGGMPADGSRCVTQLYDAGASLRNESGRRYRNNYSCHYSNSGGSGYCCCSASYRGQKGHKGGQSQVFHNSPLFMGNGGNLPPNRGVISNYHYHHHPPCGASHHHHQRCAVRSHRRRGFGAAAVEAIRSRFQAGATMSHHAPPLSAVKCNRQTKQTASNGDQEPRQAFQVPLPRSKAAAGVTQPSATSCDAGVVRPSKGDFRIEMDTPFSATDSMNDPVNGSSRLSGIAPLFDLAIQQLILECDRRVANASGTACASAHSPSNSCNSQKQSSAHFSVNTHSFDMPTASHTKTTFAQTPKESSFATFAVEQAPLEGGQLESPHRDAEAEVMARDGACTTKLHRVEPRLEERVTARRENHVGNVVGRLFRDQSEDAVDLGSDCSKLQLLIVSVGLTVSFGESAPLVLIGTLIYLFRIVKRCDSEYSSVTAANWYRLTAVALLVATKMYVDGSGSWNECFSNATDIPLKELNKLEIDFLFLLDFDALITEEEVEARADWMDSVASRHDMMTPLRTFVLGSSCAPSCVATPLSPAADEAFRSVPLGSSSNMPSTPLSLTPSNMTPVNCFSTPFTQSRPIRNQCVGSLVSGVDASDKQQQQTRPSSMRRLSSSLCPCDRMSPLPLSVSSLSLTERLFSVVHAPAEPETPPSLRRFARQDDEPVSPLTPPDQERMSPVFFFCNATRGRRCNAMTAVGEKTNKTSPAGSAVQYRVSAGVAGDAWNGDEMDEEGGTPPHPRRCILSPPTQEAAPLPPLGMTDFHHRLPRK
Protein: Rifin (Q8IIZ8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKLHYTKILLFFFPLYILEHNQNKPYITQHHTPTTTSRVLSECDIPTSNYNNDEDMKSVKENFDRQTSKRFDEYEERMKDKRQKRKEERDKNIQEIIEKDRMDKLLAEKVEKGCLRCGCALGGVAASVGLFGGLGIYVSKSAALATAIAEGAETAKAAGEAARIPAAIDAVIKGIETKFGVSTLGGQKMETFFNTTLYTEVSKIADAVYNQYAATCITSGNGARGPICTLAWQYSESRGNVVSAYNSIEVAVKPIVSQAETVAERAVKTATDEAIQRSIGVVESTYAICQTAIIASVVAIIIIALVMIIIYLVLRYRRKKKMNKKLQYTKLLNQ
Protein: Zinc finger protein 649 (Q9BS31)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.
Subcellular location: Nucleus {ECO:0000269|PubMed:15950191}.
Interaction partners:
- Transcription intermediary factor 1-beta
Sequence:
MTKAQESLTLEDVAVDFTWEEWQFLSPAQKDLYRDVMLENYSNLVSVGYQAGKPDALTKLEQGEPLWTLEDEIHSPAHPEIEKADDHLQQPLQNQKILKRTGQRYEHGRTLKSYLGLTNQSRRYNRKEPAEFNGDGAFLHDNHEQMPTEIEFPESRKPISTKSQFLKHQQTHNIEKAHECTDCGKAFLKKSQLTEHKRIHTGKKPHVCSLCGKAFYKKYRLTEHERAHRGEKPHGCSLCGKAFYKRYRLTEHERAHKGEKPYGCSECGKAFPRKSELTEHQRIHTGIKPHQCSECGRAFSRKSLLVVHQRTHTGEKPHTCSECGKGFIQKGNLNIHQRTHTGEKPYGCIDCGKAFSQKSCLVAHQRYHTGKTPFVCPECGQPCSQKSGLIRHQKIHSGEKPYKCSDCGKAFLTKTMLIVHHRTHTGERPYGCDECEKAYFYMSCLVKHKRIHSREKRGDSVKVENPSTASHSLSPSEHVQGKSPVNMVTVAMVAGQCEFAHILHS
Protein: Leucine-rich repeat (LRR) family protein (F4I0W7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Dihydrofolate reductase
- UDP-glycosyltransferase 91B1
- Protein DA1-related 2
- Cysteine-rich receptor-like protein kinase 2
- Cysteine-rich receptor-like protein kinase 10
- Methylesterase 3
- Methylesterase 10
- Acetylserotonin O-methyltransferase
- 25S rRNA
Sequence:
MMMRFTKLVWCLMFLLRFGFFTEAILDPVDFLALQAIRKSLDDLPGSKFFESWDFTSDPCGFAGVYCNGDKVISLNLGDPRAGSPGLSGRIDPAIGKLSALTELSIVPGRIMGALPATISQLKDLRFLAISRNFISGEIPASLGEVRGLRTLDLSYNQLTGTISPSIGSLPELSNLILCHNHLTGSIPPFLSQTLTRIDLKRNSLTGSISPASLPPSLQYLSLAWNQLTGSVYHVLLRLNQLNYLDLSLNRFTGTIPARVFAFPITNLQLQRNFFFGLIQPANQVTISTVDLSYNRFSGGISPLLSSVENLYLNSNRFTGEVPASFVERLLSANIQTLYLQHNFLTGIQISPAAEIPVSSSLCLQYNCMVPPLQTPCPLKAGPQKTRPTTQCTEWRG
Protein: Prolactin-3C1 (Decidualin) (Placental prolactin-like protein J) (PLP-J) (PRL-like protein J) (Prolactin-like protein I) (PLP-I) (PRL-like protein I) (Q9QUL0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Follitropin subunit beta
- Decidual prolactin-related protein
Sequence:
MQLSLTQARTWKGLLLLVSCMILWISVTPTPYDQMSNEELYDNLLSCSHRTHVVARKMYKILDLNVAERRCFKNKRNNTCHTTSTHTAKTNEDLLKVIISVSNAWIYPLKMLIPAVLTHLGSYDGMMARAIELNYGNQKILEGAKFLLSRIQPGIEENDYPVWSSLKELRSSNKSIHLFAFCKFFYCLRKDTKKIKDYLQILRPNIIKNKW
Protein: Molybdenum cofactor biosynthesis protein 1 [Includes: GTP 3',8-cyclase (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)] (Q8IQF1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.
Interaction partners:
- Molybdopterin synthase catalytic subunit
- Molybdenum cofactor synthesis protein cinnamon
- GTP cyclohydrolase 1
- Sulfite oxidase, mitochondrial
- Molybdopterin synthase sulfur carrier subunit
- Molybdenum cofactor sulfurase
- Adenylyltransferase and sulfurtransferase MOCS3
- Bis
- Guanylate cyclase
- Guanylate cyclase
Sequence:
MRLLARHAIRLLGQENSAGEVASLSRGAIRLKATTGYLNLATASVQPLEPEKQVLRKNSPLTDSFGRHHTYLRISLTERCNLRCDYCMPAEGVPLQPKNKLLTTEEILRLARIFVEQGVRKIRLTGGEPTVRRDIVEIVAQMKALPELEQIGITTNGLVLTRLLLPLQRAGLDNLNISLDTLKRDRFEKITRRKGWERVIAGIDLAVQLGYRPKVNCVLMRDFNEDEICDFVEFTRNRPVDVRFIEYMPFSGNKWHTERLISYKDTLQIIRQRWPDFKALPNGPNDTSKAYAVPGFKGQVGFITSMTEHFCGTCNRLRLTADGNIKVCLFGNKEFSLRDAMRDESVSEEQLVDLIGAAVQRKKKQHADAAPRLHHHLHPYSYHHAYHTSRLQLQARNYSQLTHVDGQGKAQMVDVGAKPSTTRLARAEATVQVGEKLTQLIADNQVAKGDVLTVAQIAGIMGAKRTAELIPLCHNISLSSVKVQATLLKTEQSVRLEATVRCSGQTGVEMEALTAVSVAALTVYDMCKAVSHDICITNVRLLSKSGGKRDFQREEPQNGIVTEVE
Protein: Transmembrane protein 107 (Q9CPV0)
Organism: Mus musculus (Mouse)
Function: Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types. During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000269|PubMed:26518474}.
Interaction partners:
- B9 domain-containing protein 1
- Transmembrane protein 216
- Transmembrane protein 231
- Coiled-coil and C2 domain-containing protein 2A
- B9 domain-containing protein 2
- Tectonic-2
- Transmembrane protein 17
- Tectonic-1
- Centrosomal protein of 290 kDa
- Meckelin
Sequence:
MGRISGLVPSRFLTLLAHLVVVITLFWSRESNIQACLPLKFTPEEYEKQDNQLVAALCLTLGLFAVELAGFLSGVSMFNSTQSLLSIAAHCSASVALSFFVFERWECTTYWYIFTFCSAFPAVTETALFIAVFGLKKKPF
Protein: AAA family ATPase (Q59WG3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Ubiquitin fusion degradation protein 1
- Nuclear protein localization protein 4
- Protein phosphatase regulator
- UBX domain-containing protein
- Protein OS-9 homolog
- RING-type E3 ubiquitin transferase
- Derlin
- UBX domain-containing protein
- Ubiquitin ligase complex subunit
- Doa1p
Sequence:
MTGEEDKKQHFDASGASAVDDKTATAILRRKKKDNALVVDDATNDDNSVITMSSNTMELLQLFRGDTVLVKGKKRKDTVLIVLADDDMPDGVARVNRCVRNNLRVRLGDIVTVHPCPDIKYANRISVLPIADTVEGINGSLFDLYLKPYFVEAYRPVRKGDLFTVRGGMRQVEFKVVEVDPEEIAIVAQDTIIHCEGEPINREDEENSLNEVGYDDIGGCKKQMAQIRELVELPLRHPQLFKSIGIKPPKGILMYGPPGTGKTIMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPSIIFIDEIDSIAPKRDKTNGEVERRVVSQLLTLMDGMKARSNVVVIAATNRPNSIDPALRRFGRFDREVDIGVPDAEGRLEILRIHTKNMKLADDVDLEAIASETHGFVGADIASLCSEAAMQQIREKMDLIDLEEETIDTEVLNSLGVTQDNFRFALGNSNPSALRETVVENVNVTWDDIGGLDNIKNELKETVEYPVLHPDQYQKFGLAPTKGVLFFGPPGTGKTLLAKAVATEVSANFISVKGPELLSMWYGESESNIRDIFDKARAAAPTVVFLDELDSIAKARGGSHGDAGGASDRVVNQLLTEMDGMNAKKNVFVIGATNRPDQIDPALLRPGRLDQLIYVPLPDEPARLSILQAQLRNTPLEPGLDLNEIAKITHGFSGADLSYIVQRSAKFAIKDSIEAQVKINKIKEEKEKVKTEDVDMKVDEVEEEDPVPYITRAHFEEAMKTAKRSVSDAELRRYESYAQQLQASRGQFSSFRFNENAGATDNGSAAGANSGAAFGNVEEEDDLYS
Protein: Cytochrome P450, family 96, subfamily A, polypeptide 3 (T8F5.12 protein) (O80806)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At4g10262
- Monocopper oxidase-like protein SKS1
- At4g10270
Sequence:
MAIVIGLLEIFTAFVFFIFFQCLLLHKKTPKPLLTNWPALGMLPGLLLQVPRIYDWITEVLEATDMTFCFKGPCLSGMDILLTVDPVNIHYILSSNFANYPKGMEFKKIFEVVGDSIFNVDSGLWEDMRNSSHAIFSNQDFQMFWVSTSVRKLRQGLVPILENAADKNILVDLQDLFQRFLFDTSLILMTGYDPKCLSVEMPKVEFGDAVDGVSDGVFYRHVKPVFLWRLQYLIGVGVEKRLKRGLAVFDQLLEKIITAKREEINSHGTHHPSRGEAIDVLTYYMTMDTTKYKYLEPSDDRFIKDTILGFLIAARDTTSSALTWFFWLMSKNPEAINKIRQEVNKKMPRFDPADLEKLVYLHGAVCETLRLYPPVPFNHKSPAKPDVLPSGHRVDEKWKIVISMYALGRMKSVWGDDAEDFRPERWISDSGRLKHEPSYKFLAFNAGPRACLGKKLTFLQMKTVAAEIIRNYDIKVVEGHKTEPVPSVLFRMQHGLKVNITRI
Protein: Cytosolic protein (A0A0H3K9R5)
Organism: Staphylococcus aureus (strain Newman)
Interaction partners:
Sequence:
MGYSIVRNVNEGVNAMTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQEEAMEELLVTFQKLIKD
Protein: Prophage bactoprenol-linked glucose translocase homolog (Bactoprenol-linked glucose translocase homolog from prophage CPS-53) (P77682)
Organism: Escherichia coli (strain K12)
Function: Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity).
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Prophage bactoprenol glucosyl transferase homolog
- Prophage integrase IntS
- Uncharacterized protein YfdI
- Inner membrane protein YfdC
Sequence:
MLKLFAKYTSIGVLNTLIHWVVFGVCIYVAHTNQALANFAGFVVAVSFSFFANAKFTFKASTTTMRYMLYVGFMGTLSATVGWAADRCALPPMITLVTFSAISLVCGFVYSKFIVFRDAK
Protein: Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) [Includes: Alkaline phosphodiesterase 1 (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)] (P25353)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP2 and PHO5.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein YCR025C
- Ectonucleotide pyrophosphatase/phosphodiesterase 2
- Outer spore wall assembly protein SHE10
- Outer spore wall protein 7
- Ribosomal RNA small subunit methyltransferase NEP1
- Outer spore wall protein 6
Sequence:
MELQNDLESLDNELNDFSEDPFRDDFITDEDAVRSGWRSAWTRMKYWFYKNRLKWTNNPIVIGDAKDSRDGSNFRRGIPLYELDANGQPIDTELVDENELSFGTGFHSKVPFKIIFRTLFGSLVFAIFLILMINIAKPHHSTRVLSHFGSPEFDPYVKYFNGTHEFFPLTIVISLDGFHPSLISKRNTPFLHDLYELKYDGGMNITSTPFMVPSFPTETFPNHWTLVTGQYPIHHGIVSNVFWDPDLNEEFHPGVLDPRIWNNNDTEPIWQTVQSAFDGDIPFKAATHMWPGSDVNYTKYNEEKLQPEHKNPIARERTPFYFDEFNAKEPLSQKLSKIIEYVDMSTLNERPQLILGYVPNVDAFGHKHGYPSESEYYYEDFTETLGEVDTFLKQLVESLQERNLTSFTNLVIVSDHGMSDIVVPSNVIIWEDLLDEKLRKDYVSHAYLEGPMMAISLKDSGNINEVYHNLKTSIDEDKYTVYVNGNFPKEWNFNDGKNHHMASIWIVPEPGYAVMKKEQLKKVAKGDHKDKNEDNVFTIGSHGYDNNAIDMRSVFIGMGPYFPQGYIEPFQNTEIYNLLCDICGVAEKDRNSNDGTGMLMNQLREPQSSEEVEIEDDFDYLVSKFGEFSTYNIIWGGYPEETEQDNVDNDNDDNDDGNTDEIAAMPSSSLTIKLEMTTSIPSATETLLGETSPSSRSSSSSSIQASATASTVGDWLQDIINDAKDLIDDIIDSIDDLVDSDT
Protein: Prorelaxin H2 [Cleaved into: Relaxin B chain; Relaxin A chain] (P04090)
Organism: Homo sapiens (Human)
Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
Subcellular location: Secreted.
Interaction partners:
- Relaxin receptor 1
- Relaxin receptor 2
- Insulin-like peptide INSL5
- Relaxin-3
- Insulin-like 3
- Prorelaxin H1
- Relaxin-3 receptor 1
- Relaxin-3 receptor 2
- Early placenta insulin-like peptide
- Insulin
Sequence:
MPRLFFFHLLGVCLLLNQFSRAVADSWMEEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETINMMSEFVANLPQELKLTLSEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSSPSELKYLGLDTHSRKKRQLYSALANKCCHVGCTKRSLARFC
Protein: Desert hedgehog protein (DHH) (EC 3.1.-.-) (HHG-3) [Cleaved into: Desert hedgehog protein N-product (DHH-N)] (O43323)
Organism: Homo sapiens (Human)
Function: The C-terminal part of the desert hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (N-product and C-product) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Functions in cell-cell mediated juxtacrine signaling. Promotes endothelium integrity. Binds to PTCH1 receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes in endothelial cells. In Schwann cells, controls the development of the peripheral nerve sheath and the transition of mesenchymal cells to form the epithelium-like structure of the perineurial tube (By similarity).
Subcellular location: [Desert hedgehog protein N-product]: Cell membrane {ECO:0000250|UniProtKB:Q62226}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}.; SUBCELLULAR LOCATION: [Desert hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Secreted {ECO:0000269|PubMed:33063110}. Cell membrane {ECO:0000269|PubMed:24342078}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}.
Interaction partners:
- Hedgehog-interacting protein
- Protein patched homolog 1
- Cell adhesion molecule-related/down-regulated by oncogenes
- Protein patched homolog 2
- Brother of CDO
- Growth arrest-specific protein 1
- Protein smoothened
- Sonic hedgehog protein
- Indian hedgehog protein
- Low-density lipoprotein receptor-related protein 2
Sequence:
MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG
Protein: Fcgbp protein (Q8R1J5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
AISSPGVYELSSRCPGLQKNVPWYRVLADVQPCHNNDKIVSKVHIFFQDGLVTVIPSKGAWVNGLRVDLPATVLTSVSVRRMPDGSMLVHQKAGVTVWLGKDGLLDVMVGDDLAAMLCGACGNFDGDQTNDAYGSQGKTPIEKWRAQDFSPCSN
Protein: Autophagy-related protein 22 (Q09812)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:21307582}; Multi-pass membrane protein {ECO:0000269|PubMed:21307582}.
Interaction partners:
- Putative lipase atg15
- Vacuolar amino acid transporter 3
- Autophagy-related protein 8
- Ubiquitin-like modifier-activating enzyme atg7
- Endoplasmic reticulum chaperone BiP
- Serine/threonine-protein kinase atg1
- Vacuolar amino acid transporter 5
- Tryptophan synthase
- Vacuolar membrane amino acid uptake transporter fnx2
- Autophagy-related protein 3
Sequence:
MNSPIQLHKKFSTTVWHVLSWILYAVGAGPTAIISMGVYVPLIVMKNAHDHGFLRTDHTIPCSLYPEEPCSLNIVGPLWIDVSSIVFAASAISTFLQMAMMVSLGVICDYGNNRRYILFSCVIIGSISGIILSWSPSSFLLGKIVFLILVDLNFIISQSCYDSFLPIFLRFYPITRGPITLESALQDETDDLDSYITNTTIDSSEEEPYLLEHSLILNESAPPADVEDEHKAKIAARLSSVGFGSFFGAAILFQIIFTPILYKTNNNPIILPITVTVCSCWWLILSTPLCTIVTLPVENHSSDAILTLLYNSVKESYHSFKHAMSISSIRLFLFSRLFINCGIQTSLSSAVIFGKARLNLSNFQLTLLGMGISSFALLGTVIIPYLTEYFQLNSLQVVMIISILLPMAPLYGLLGYIPGFENAGIRTSADVFRATLFFGFFLGGAHSYCRSVYAQLVPSGKETRFFALYALISQTGVLFSHISLTLISNYTSDLRAVYIFVIVVMTLPLSSLWIMYQHSKTPNLHRSSS