wanglab/gogpt-training-data huggingface dataset:
Protein: Protein INO2 (P26798)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Positive regulatory factor required for depression of the coregulated phospholipid biosynthetic enzymes. Also involved in the expression of ITR1.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein INO4
- Transcriptional repressor OPI1
- Inositol-3-phosphate synthase
- Phosphatidylethanolamine N-methyltransferase
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- Acetyl-CoA carboxylase
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Transcriptional activator HAC1
- Vesicle-associated membrane protein-associated protein SCS2
- Phosphatidic acid phosphohydrolase 1
Sequence:
MQQATGNELLGILDLDNDIDFETAYQMLSSNFDDQMSAHIHENTFSATSPPLLTHELGIIPNVATVQPSHVETIPADNQTHHAPLHTHAHYLNHNPHQPSMGFDQALGLKLSPSSSGLLSTNESNAIEQFLDNLISQDMMSSNASMNSESHLHIRSPKKQHRYTELNQRYPETHPHSNTGELPTNTADVPTEFTTREGPHQPIGNDHYNPPPFSVPEIRIPDSDIPANIEDDPVKVRKWKHVQMEKIRRINTKEAFERLIKSVRTPPKENGKRIPKHILLTCVMNDIKSIRSANEALQHILDDS
Protein: NifU-like protein, mitochondrial (P32860)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in iron homeostasis within the mitochondrion where it is involved in the assembly of iron-sulfur proteins. Together with BOL3, required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein. Required for protecting iron sulfur clusters from oxidative damage.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:10468587}.
Interaction partners:
- Cysteine desulfurase, mitochondrial
- Iron sulfur cluster assembly protein 1, mitochondrial
- Iron sulfur cluster assembly protein 2, mitochondrial
- Frataxin homolog, mitochondrial
- Iron-sulfur assembly protein 1
- Iron-sulfur cluster assembly factor IBA57, mitochondrial
- Aconitate hydratase, mitochondrial
- Iron-sulfur assembly protein 2
- Lipoyl synthase, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
Sequence:
MFKSVAKLGKSPIFYLNSQRLIHIKTLTTPNENALKFLSTDGEMLQTRGSKSIVIKNTDENLINHSKLAQQIFLQCPGVESLMIGDDFLTINKDRMVHWNSIKPEIIDLLTKQLAYGEDVISKEFHAVQEEEGEGGYKINMPKFELTEEDEEVSELIEELIDTRIRPAILEDGGDIDYRGWDPKTGTVYLRLQGACTSCSSSEVTLKYGIESMLKHYVDEVKEVIQIMDPEQEIALKEFDKLEKKLESSKNTSHEK
Protein: Cyclic GMP-AMP synthase-like receptor 2 (cGLR2) (EC 2.7.7.-) (EC 2.7.7.86) (A8DYP7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP from ATP and GTP and plays a key role in antiviral innate immunity. Directly binds some unknown nucleic acid, activating the nucleotidyltransferase activity, leading to synthesis of both 3',2'-cGAMP and 2',3'-cGAMP second messengers. 3',2'-cGAMP and 2',3'-cGAMP bind to and activate Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish).
Interaction partners:
Sequence:
MKESRNLENFVEKKLYECKKKYVDIPKDEGQRYGGKHYEALTSKIFEILRKENPELDIIIAEFSLEGSVGMLKIAKPNEFDLVFKLKFPYYKSIAVTRDPKIPGNVLLDMTRVLELLKDDPREDFQRIRELIQGRLVDAQNFFVVDRLRSWLQSLFSQALNRISYRVELVAGVVSHLKYRTCGPAHTIYVYGDYEYSVDYVPAICLAAEQNVLPTKQLECFKRANTSYWEAIPKPLKPLTETSMISFRSSFYAVEKILLQDVHENCRNAIRFMKKFRDVKTNLGNCKSYYIKTLFLWKIIQEPESYWLNPLSFILADMFDDLAENLRRGVITFFWDPELNMIDALTRDQVWEMYLCVQRIPRDLRGAEISRNKWSFFVLREFSHKKERNVNLKCSSRRKRNVIKGLKTTSICKLRNARTNGTWTAGLWTRPGHAYRGPSETVSTWDTVKDAAWSEGIVE
Protein: Large neutral amino acids transporter small subunit 1 (Q19834)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Glycosyl hydrolase family 13 catalytic domain-containing protein
- alpha-glucosidase
- Potential vesicular glutamate transporter vglu-3
- Autophagy-related protein 2
- Large neutral amino acids transporter small subunit 1
- Metallo-beta-lactamase domain-containing protein 1
- Na
Sequence:
MTAEKEPLKSREGDEAPQNETEGKGKGLEKSLTLFNGVSMIVGCIIGSGIFVSPTGVQEQAGSVGLSLIVWLISGIFTAIGAYCYAELGTLIKKSGGDYAYIMEAFGPFVAFIRLWIEAIVVRPCTVTIVALTFAIYGLRPFFPDCAPPDVVAELLAILLIVLMTAINCISVRLATIVQDWFTIAKVVALCLIILTGLGLLFFGESQYKDSFENIFENTSQDFTKVSLAFYSGLFAYSGWNFLNFIVEELQNPKRNLPLAIAISITSCTVIYVLTNVALYTAISPDEMLESPAVAVLFANKLYGKFAFIMPLCVACSTIGSANGVIFTSARLFYSGAREGQMPAVLTMINKKTKTPIPAVILTGALSIAYLLASKDVYQLINYIQISYWLAIGTAIAALFWLRRTMPDASRPIKVPLIWPAIFLAGCIALVLIPMVAAPRDTGIGLLIMLSAVPVYGIFIGWKNKPKWFNEFIDSSTVFIQKLFMVVDEDKED
Protein: Oxysterol-binding protein homolog 4 (Bypass SECl4 recessive protein 3) (KRE11-1 suppressor protein 1) (Protein KES1) (Oxysterol-binding protein-related protein 4) (ORP 4) (OSBP-related protein 4) (P35844)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis. Involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum. Specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation. Thus, by maintaining a PI4P gradient at the ER/Golgi interface, SAC1 may drive PS transport. Displays a similar affinity for PI4P and sterols. Binds sterol and PI4P in a mutually exclusive manner. Involved in ergosterol transport from the plasma membrane (PM) to the ER. Mediates sterol transport from the ER to mitochondria. Involved in the negative regulation of Golgi-derived transport vesicle biogenesis. Plays a role in the positive regulation of vesicular transport of ceramide from the ER to the Golgi, negatively regulating COPII-mediated ER export of cargos.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8978672}. Golgi apparatus membrane {ECO:0000269|PubMed:11916983}.
Interaction partners:
- SEC14 cytosolic factor
- Oxysterol-binding protein homolog 3
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 4-kinase PIK1
- Phospholipase D1
- Phospholipid-transporting ATPase DRS2
- Ras-related protein SEC4
- Phosphatidylinositol 4-kinase STT4
- Protein PRY1
- Phosphatidylinositol transfer protein PDR17
Sequence:
MSQYASSSSWTSFLKSIASFNGDLSSLSAPPFILSPISLTEFSQYWAEHPELFLEPSFINDDNYKEHCLIDPEVESPELARMLAVTKWFISTLKSQYCSRNESLGSEKKPLNPFLGELFVGKWENKEHPEFGETVLLSEQVSHHPPVTAFSIFNDKNKVKLQGYNQIKASFTKSLMLTVKQFGHTMLDIKDESYLVTPPPLHIEGILVASPFVELEGKSYIQSSTGLLCVIEFSGRGYFSGKKNSFKARIYKDSKDSKDKEKALYTISGQWSGSSKIIKANKKEESRLFYDAARIPAEHLNVKPLEEQHPLESRKAWYDVAGAIKLGDFNLIAKTKTELEETQRELRKEEEAKGISWQRRWFKDFDYSVTPEEGALVPEKDDTFLKLASALNLSTKNAPSGTLVGDKEDRKEDLSSIHWRFQRELWDEEKEIVL
Protein: G-protein coupled receptor Mth (Protein methuselah) (P83120)
Organism: Drosophila simulans (Fruit fly)
Function: Involved in biological aging and stress response. Essential for adult survival (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- GD12325
Sequence:
MKTLFVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQKVASHIRGCVCKLKPCVRFCCPHDHIMDNGVCNDNMSEEELTELDPFLNVTLDDGSVSRRHFKNELIVQWDLPMPCDGMFYLDNREEQDQYTLFENGTFFRHFDRVTLSKREYCLQHLTFADGNATSIRIAPHNCLIVPSITGQTVVMITSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLFDLWQISISFCKPAGVLGYFFVMAAFLWLSVISLHLWNTFRGSSHKASRFFSEHRFLAYNTYAWGMSMVLTGITVLADNVVEDQDWNPRVGEEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTARRIIGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYISQSNQTWANVFLVADYLNWSQGIIIFILFILKRSTLRLLQESIRGEGEEVDNSEEEISLENTRFDRNVLS
Protein: Replication factor C subunit 1 (A1-P145) (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (Differentiation-specific element-binding protein) (ISRE-binding protein) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) (P35601)
Organism: Mus musculus (Mouse)
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction.
Subcellular location: Nucleus.
Interaction partners:
- Replication factor C subunit 5
- Replication factor C subunit 4
- Replication factor C subunit 3
- Replication factor C subunit 2
- Proliferating cell nuclear antigen
- Replication protein A 70 kDa DNA-binding subunit
- Flap endonuclease 1
- ATPase family AAA domain-containing protein 5
- Chromosome transmission fidelity protein 18 homolog
- DNA polymerase epsilon catalytic subunit A
Sequence:
MDIRKFFGVISSGKKPVNETVKNEKTKASEGTVKGKKGVKEAKVNNSGKEDASKPKQHSKKKRIIYDSDSESEETVQVKNAKKKSEKLSLSYKPGKVSQKDPVTYVSETDEDDDFVCKKAASKSKENGVSTNSYLGTSNVKKNEENVKTKNKPLSPIKLTPTSVLDYFGTESVQRSGKKMVTSKRKESSQNTEDSRLNDEAIAKQLQLDEDAELERQLHEDEEFARTLALLDEEPKIKKARKDSEEGEESFSSVQDDLSKAEKQKSPNKAELFSTARKTYSPAKHGKGRASEDAKQPCKSAHRKEACSSPKASAKLALMKAKEESSYNETELLAARRKESATEPKGEKTTPKKTKVSPTKRESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLTFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKILDEDGLLDLIRTMPGKRSKYEMAAEAEMKKEKSKLERTPQKNDQGKRKISPAKKESESKKCKLTLLKNSPMKAVKKEASTCPRGLDVKETHGNRSSNKEECLLWVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAAKFGKLASKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTSGAAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQSKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGEETAHMSLMDKSDLFFHDYSIAPLFVQENYLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSLLPTQAIYASVLPGELMRGYMTQFPSFPSWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTVNMDYLSHIRDALVRPLTSQGVEGAQHVIKLMDTYYLMKEDFENIMEVSSWGGKPSAFSKLDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSTGPALDSEYSEEFQEDDTQSEKEQDAVETDAMIKKKTRSSKPSKSEREKESKKGKGKNWKK
Protein: Protocadherin related 15 (A0A8I6B3E0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MSPQFALWKCMPHGILLASLLIVSWGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFAGDNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNYEDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPILVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFLHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYILESAPVGATISESLNLTTPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTPTGITRYLTLLQPVDREEQQTYTFLITAFDGVQESEPVVVNIRVMDANDNTPTFPEISYNVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGSKGDFVINRTTGLVSIAPGVELVVGQTYALTVQASDNAPPAERRHSICTVYIEVLPPNNQSPPRFPQLMYSLEVSEAMRIGAVLLNLQATDREGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTAFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFDVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVRILVLHPGEIPRFTQEEYRPPPVSELAARGTVVGVISAAAINQSIVYSIVAGNEDDKFGINNVTGVIYVNSPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENDHPPVFQKKFYIGGVSEDARMFTSVLRVKATDRDTGNYSAMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYSKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQSAMPAAKPAAPVPAAPPPPPPPPPPGAHLYEELGESAILFLLYHFEQSRGNNPVPEDRSSHRDGMAFSSSTTESHEPAHVEGPLDNQANPARTFSFLPDEDDLSTHNPLYMESIGQRSTNSDLQPGTEFGELFVPRTQVKSQSLRGPREKIQRVWNQSVRFPRRLMWKTPNRPETIDLVEWQITRQRAECEKTRCHPSQQGSSNLMVTTEDARGSEKEGGHRDTLIVQQTEQLKSLSSGSSFSSSWSHFSFSTLPTISRAVELGSEPDVVTSPADCTLELSPPRRPRVLNSLGSKRETPTCASDTETKRNSFEMVPHPPSISAPLPQLPLPQPPIAFTTFPLPLSSPNPPRPQLLTFSLPISTTPASSLPPPPPPSLPPPPRPPAPRLFPLPPSTSVPSTDSISTPAAKCTASVTHARETMSTTQPPASNPPCGAEPHRHPKGILRHVKNLAELEKSVSNMYSHIEKNCPPTELSKLHPFCPAEKTNMKITCDQSQETLVRVVEGIDVQTHSQSTSL
Protein: Protein canopy homolog 3 (Protein associated with Tlr4) (Trinucleotide repeat-containing gene 5 protein) (Q9DAU1)
Organism: Mus musculus (Mouse)
Function: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:17998391, ECO:0000269|PubMed:20865800}.
Interaction partners:
- Endoplasmin
- Protein unc-93 homolog B1
- Toll-like receptor 9
- Lymphocyte antigen 96
- Toll-like receptor 7
- Protein canopy homolog 2
Sequence:
MESMSELAPRCLLFPLLLLLPLLLLPAPKLGPSPAGAEETDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIDTGYGILDGKGSGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAERWSGKKGDIASLGGKKSKKKRSGVKGSSSGSSKQRKELGGLGEDANAEEEEGVQKASPLPHSPPDEL
Protein: Protein trichome birefringence-like 23 (O82509)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- At5g50410
- F21B7.2
- At2g39980/T28M21.14
Sequence:
MKLKWESISNLQQNTYLIKLVAATLITCLAFRFFVFRFGQFSPVQVSVTGNSNSQISPTSVILSDNEDQIPVDIEVEKCDLFTGKWIKDPLGPIYTNESCGIVVDAHQNCITNGRPDSGFLNWKWKPNDCSLPRFDSLRFLQLMRNKSWAIIGDSIARNHVESLLCMLSTVEKPVEVYHDENYRSKRWHFPSYNFTVSNIWSPFLVQADIFEDSNGVSSAAVQLHLDKLDNTWTDLFPSLDYAIISSGEWFLKTAVYHENANPVGCHGCPESSNMTDLGFDYAYNTSLRHVMDFIAKSKTKGMIFFRTSIPDHFEDGEWHNGGTCKKTEPVGEEAVEMKVLNKILRDVEINQFERVVTEMGQESENLKLLDFAGMLLTRPDGHPGPYREFRPFDKDKNATVQNDCLHWCLPGPIDHLNDVILEIIVNGRTGK
Protein: Interferon-induced GTP-binding protein MxB (IFN-inducible antiviral protein MxB) (Interferon-inducible MxB protein) (Q800G8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Protein kinase-containing Z-DNA-binding domains
- Interferon-induced protein with tetratricopeptide repeats 5
- Ubiquitin-specific peptidase 18
- Immunoglobulin heavy variable 4-9.
Sequence:
MEKMSYTFSQQYEEKIRPCIDTIDNLRSLGVEKDLALPAIAVIGDQSSGKSSVLEALSGVPLPRGSGIVTRCPLELKMIRSKEDEKWHGRISYQNHEEDFDDPAEVEKKIREAQDEMAGAGVGISEELISLQITSANVPDLTLIDLPGIARVAVKGQPENIGDQIKRLIRMFITKQETINLVVVPCNVDIATTEALQMAQAEDPEGERTLGILTKPDLVDKGTEGTVVDIVHNEVIHLTKGYMIVRCRGQKEIMDQVTLNEATETESAFFKDHPHFRKLYEEGFATIPKLAEKLTIELVHHIQRSLPRLEDQIQTKLAETQKELEAYGDGPPSDPAERLSFFIDKVTAFTCDTLNLTTGEEVKSASKLLIFPELRQEFAYWNSFLDSSGYSFKLKIEEEVDNYEVKYRGRELPGFINYKTFEGLVREQMKLLEEPALKMLKNVSDMVKKKFIQLAQSSFTGFPILLKIAKTKIEAIKQDKECLAESMLRTQFKMELIVYTQDGTYSQSLLRSKEKREEDEEDTENFDCMTVGIATSNHATLSEMKLHLESYYMIASQRLADQIPMVIRYLLLQEAALELQRSMLQLLQDKDGVDDMLKEDFDIGQKRENLLSRQKRLMKAQNLLATY
Protein: Solute carrier family 26 member 6 (D3Z9I5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Cystic fibrosis transmembrane conductance regulator
- Na
- Sodium/hydrogen exchanger 3
- Electrogenic sodium bicarbonate cotransporter 1
- Sodium/hydrogen exchanger 1
- S-adenosylhomocysteine hydrolase-like protein 1
Sequence:
MGLPDGSDHGTQQTQALLSATQEMELERRDYHVERPLLNQEQLEDLGHWGPVSKTHPWRTWFRCSRARAKSLLIQHVPVLGWLPRYPVREWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPMFGLYSSFYPVFVYFLFGTSRHISVGTFAVMSVMVGGVTESLTADEAFVQSLNTTVDGARVQVAYTLSFLVGLFQVGLGLVHFGFVVTYLSEPLVRSYTTAASVQVLVSQLKYVFGIKLNSHSGPLSVIYTVLEVCAQLPKTVPGTVVTAIVAGVVLVLVKLLNEKLRRRLPLPIPGELLTLIGATAISYGVKLNDRFKVDVVGNITTGLIPPVAPKTELFATLVGNAFAIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGFFQCFPVSCSMSRSLVQESTGGNTQIAGAVSSLFILLIIVKLGELFRDLPKAVLAAVIIVNLKGMMKQFSDICSLWKANRVDLLIWLVTFVATILLNLDIGLAVSIVFSLLLVVIRMQLPHYSVLGQVPDTDIYRDVAEYSGAKEVPGVKVFRSSATMYFANAELYSDSLKKKCGVDVDRLITQKKKRIKKQEMKIKRMNKAKKSQKQAASSKISSVSVNVNTNFEDIKSNDVEGSEAKVHQGEELEDVVASNQEDAKPPIMTSLKALGLPQPDFHSLILDLSTVSFVDTVCIKSLKNIFRDFREIEVEVYIAACYSPVVTQLEAGHFFDESITKQHVFASVHDAVTFALHHRKSGPKSPVLATKL
Protein: P-type domain-containing protein (Q19004)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Alpha-amylase
- Glycoside hydrolase family 1 protein
- Phosphotransferase
- Mannosyl-oligosaccharide glucosidase
- ShKT domain-containing protein
- P-type domain-containing protein
- Glucosidase 2 subunit beta
- Alpha-1,4 glucan phosphorylase
Sequence:
MFLKKGSTIVVLLLVFYQNTNSQSVDVSKRVDCYPEPGASQDACQSRGCIWTEAPSSSPVGTPWCYYPTESGFTVQSTGTNSFVLAAKTKNPYGNNISPLNVKYSSNGATLLLTIGNDDRYVPPVNFPKKPSTSTESLKFTSGTIGSSDVFSFKVTRASTGVALWDTSIGGMQFADKFIQIATYLPSKNIYGFGDHIHKKIRHNLDRYTTWPMFARDIGPDSGSALSTQNLYGVHPFYMCIEADGKAHGVFILNSNAQEVETGPGPHLLYRTIGGRIDMAFFPGPTPEQVVNQYLQHIGFPFLPAYWALGYQLCRWGYGNLDAMKTVISRNQALGIPLDVPYADIDYMNHYEDFTEGDNWSGFPAYTQQIHAQGLHLIVIFDPAVEVDYASFQRGINADASFIEWARDDQVPHNIQDQYPMAKNTKIMLGNVWPDRNTAFPDFLDPRNNTNAWWAGEFAQFHKTLPFDGMWIDMNEPSNFDTGTYNTVEEQLASAKLSCPITGSDSSLDVPPYPTQAVYQRNGEYLFSKTLCMLGKTAHRTRDFYDTKNLYGWSEARATYQAIPQVTGKRSAVISRSTFPSSGRYGGHWLGDNTARWGDLQTSVIGVMEFNMFGVPYVGSDICGFNGVSNEELCLRWHQFGAFSPFSRDHNSEGMPDQDPAVWPSVANAAKIALTFRYYFLPFLYSLHYNAARYGHTVIRPLFFEFPKDEETLNISEQFLWGSALMIAPALYQGQTSVHAYFPSDTWYSLQPETYGQKMFSGFNDVNAPLSSLTPVFVRGGFVLPRQSPGTTTTASRLSPFELLITVKTNAASSGDLYYDGGDDLIPNDDIEQHPRVHWQFSFTSSIAGGVLTGNCETCSTAVRPPTLDIIEILGYPSSPNFNGFKLDGSSVTLDMTKTSYNSANQRVMISARNMISLMALKKKFTLSFTNLNVYL
Protein: Kinetochore protein spc24 (Q9UST6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:15728720}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15728720}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}. Note=Associated with kinetochores. {ECO:0000269|PubMed:15728720}.
Interaction partners:
- Kinetochore protein nuf2
- Kinetochore protein spc25
- Kinetochore protein ndc80
- Kinetochore protein mis13
- Outer kinetochore KNL1 complex subunit spc7
- Kinetochore protein nnf1
- Kinetochore protein mis14
- Centromere protein mis12
- Outer kinetochore KNL1 complex subunit sos7
- Monopolin complex subunit pcs1
Sequence:
MSDSPIELMRSTLAGFQIAPDVKTISNIQDIRAQIQSFREKELEGSQTKFKVLSRKLEISTQAMESLKQTAESSQHAEEILSREKEKFRIAKLLNITENEIMSLESQLQKMKEQLLQLEERENTSEDICQSEENANMLKLNFYHSLGFDLETAENTGNKRVIIHTENDLQTVQISNKYSPYFYSNYFWDLLDDSKDKK
Protein: Transcription factor AZF1 (asparagine-rich zinc-finger protein 1) (P41696)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Potential transcription factor; suppressor for a mitochondrial RNA polymerase mutant.
Subcellular location: Nucleus {ECO:0000269|PubMed:22932476, ECO:0000269|PubMed:34019539, ECO:0000269|PubMed:9799362}. Cytoplasm, cytosol {ECO:0000269|PubMed:22932476}. Note=relocalizes to the cytosol in response to hypoxia. {ECO:0000269|PubMed:22932476}.
Interaction partners:
Sequence:
MPPPTAQFMGPTQAGQNESQNQSSGEAGEQNQEHGQGPTPILNQSQPASSQPQHQQQRNESISYYTNFNQPRYSTDASINSFLNISDNVPVTSTGGPSSGGAYSNLPRLSTSSTHQPPDLSQIGRGFSIVNNLFPQQQQLQNQHRQQQQQQQQQSHQQPPFKTPSFSTGLTGSSSQYQFLPRNDNTSQPPSKRNSVYLGPNDGPDFEFFSMQQSQQPQFQPSSRRESNSMRPPLLIPAATTKSQSNGTNNSGNMNTNADYESFFNTGTNNSNSNQNPYFLSSRNNSLKFNPEDFDFQFKRRNSFVRGTLDHSSQNAFIPESRLNSLSVNNKANGDPVADNVTNNMKGKSNEVDNDDGNDSSNNNNNNNNNNNNENNNDNNNDNNDNSINSATSTNIPNQEDHSLASTDTTSNSRKDLKEIEQRLRKHLNDEDNYSSAISRPLDKNDVIEGSEGLNKHIDESGMQPNIIKKRKKDDSTVYVKNEMPRTDPPMSKDNSTSAEGAAMANFSGKEPPIPDISSVSDDATNLIGATKVDQLMLIIQARKKGFTEKVNTTQDGDLLFNQTMDILPPKSELVGGVEKPKGTQNTRAVKKHECPYCHRLFSQATHLEVHVRSHIGYKPFVCDYCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHLVTHQKLKPFVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSENIPLEERQLLEYFASIYKNSNRGIKGRGKGVGTKKSTISSPENHPASTILNPNTNANNAIANDSENNGNPEGNIDSSSNSNPGSHSMISPTQKDMGTLQSQFIQNNFNNSVNSSNPSNQPIINYNYTTLPHSRLGSSSSSNTNNNNSNFSVGAAPGVLMAPTTNNDFSFNLDQSNDNERSQQEQVRFKNINYKS
Protein: Toxin RelG (EC 3.1.-.-) (Putative endoribonuclease RelG) (O33348)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriostatic rather than bacteriocidal fashion. Its toxic effect is neutralized by coexpression with cognate antitoxin RelB2 (shown only for M.smegmatis). Overexpression also increases the number of gentamicin-tolerant and levofloxacin-tolerant persister cells.
Interaction partners:
- Antitoxin RelF
- Antitoxin RelB
- Toxin RelK
- Antitoxin RelJ
Sequence:
MPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDHRADIYRR
Protein: E3 ubiquitin-protein ligase brl1 (EC 2.3.2.27) (BRE1-like protein 1) (RING finger protein 2) (RING-type E3 ubiquitin transferase brl1) (Q1MTQ0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 2
- Small histone ubiquitination factor 1
- E3 ubiquitin-protein ligase brl2
- PWWP domain-containing protein 3
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
Sequence:
MSVVNESRKRRRLIHSEKETRRLDLGEEDDLELFQKEAAWRRSREYEHLTVLEKKLYEYWESLVLKLDHYVAAALENHEQSFEELEKITASLYQPDDNLQTLDLSLAEFSLIKDAQNYLNKYASYFQAHEPTLQKLAKFGSFKLKETPNVHEWIDQRQVHFTSMINYRTSQLKLALLKRKLSFFREALNSAELEWKRVQQDQLTSASERSIENIADDIPASEPKAILENGEGCLNDNDNISKLKNNFQSQADLMQANINSKLDELSQKSTRAAQLYVDIMGITDERVSREPHYLELKGVLSSNEEKIESINRDLSSLFEDIQFFISQRTKRQKDIIDLKLACVKEKQQLIKTLESSLTQIRNERDSLVAKQQMQYTNNLFFDDMMLLLSNLSNARVAILEGYSNRLCIWDRIERSKTGEMNNVLDEKEEISASSALEKLIKNNSCLEAELPSMYAAFDQSQSRLLKKYEELETKEKKALEMHYEKARATQKYFAAMKARDILMTEKKTLKLAENKEHDYIGKLQEREHALTKYESSLKAELEVYKQIKEIYGKHSVEVLTEDKHLQVKQTKLTQKLEDLIESVQKSGEKLMIMHQKLFHLQEEHTILSIKASYNKKESHLINQAYETQEAQVYKGMLKCSVCNFSNWKSKLIPNCGHAFCSNCMEPFYEHKTSTCPQCETPFSVSDILTIHL
Protein: Uncharacterized membrane protein PB8E5.08 (Q9C0X7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MRKLRCKQMIPKLLPFIFIYLSVANKIMFYCILNERAFKHYKTYRRITDCPEIKNKKSRRKNQRNSSSIGLSNPNKFSIYIYIYFFFYSFLCSPYLFKYISLF