wanglab/gogpt-training-data huggingface dataset:
Protein: Insulin receptor substrate 4 (IRS-4) (Phosphoprotein of 160 kDa) (pp160) (Q9Z0Y7)
Organism: Mus musculus (Mouse)
Function: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Interaction partners:
- Growth factor receptor-bound protein 2
- Suppressor of cytokine signaling 4
- Insulin-like growth factor 1 receptor
- Insulin receptor
- Insulin-1
- Insulin-2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Tyrosine-protein kinase JAK2
- Serine/threonine-protein kinase mTOR
- Tyrosine-protein phosphatase non-receptor type 1
Sequence:
MASCSFSGHQALRRLRASAAAAASAALAAVATTPLLSSGTRTALIGTGSSCPGAMWLSTATGSRSDSESEEEDLPVGDEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYRNARKFRHSVRAAAAAAEAAASGAAVPALIPPRRVIILYQCFSVSQRADARYRHLIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGALPDGEPAALAAAAAAEPPFYKDVWQVVVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDSVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSTRRHLGLLPLEPGGWLRRYGLEQFCRLRAIREREEMLFTRRFISPREPPPPFRRGRGHLPRARRSRRAASVPPSLFRRSAPSPGRIPQPEDVPNDRAREASGSSSGNTEEKDKEGEEGNRGDCIPMNNWGSGNGRGSGGGRGSSGQGSSSQGSGGRQGSGGGQGSGGQGAGGNQCSGNGQGTAGGHGSGGGGHGSGGGQRPGDGHGSGGGKNSGSGKNSDDGDRGKSVKKRSYFGKFTQSKQQQTLPPPPPPPPAAGATGGKGKSGGRFRLYFCADRGTKERKEAKEVRDMETSGGATRGPYRARAFDEDEDDPYVPMRPGVAAPLACSSDYMPMAPQNSSASTKRHSRSPFEDSRGYMMMFPRVSPPPPVPSAPKAPDTNKGDDSKDNDSDSDYMFMAPGAGAIPKNPPNAQGGSSSKSWSSYFSLPSPFQSSPLGQSDHSEYVPMLPGKFLGSGLHKEASFSQGTKNVSSKPSTEASFSKPEDKGSSAKPSDDVPPMNKAKEPNHLSFIAKGTQVKPKPLNPTQERREAAGSRDYINIDFIKRERLVLPSSAQGLPDMRGVVTDPAPTAFSGYLNVEFGVPFPNPTIRLSDLLRVLPGANSIPLAGTRWPFPGSAIGSIVEAGEYIEVIFNPAMTPAMSFADSAICYDAQTGQIYVVDPFSECCMDVSLSPGRCSEPPPVARLRREEAQERRRPQSRSQSLFASTRAAVSAFPTDSLDRDFPAASAVIAAPAEAPLLAVSRALAVVSALAAAPSIGDVFAGFRAAAGVDSASARGFQPVAGAQAVREFQDLAAGWNPGALNHRARGEDLAAGAAAPPPPPRQIWVLRPQERADSEDDDDDDDDIYVRMDFARRDYRK
Protein: Vitamin D3 hydroxylase-associated protein (VDHAP) (Q90578)
Organism: Gallus gallus (Chicken)
Function: May have a vitamin D3 hydroxylase regulatory function.
Subcellular location: Mitochondrion inner membrane.
Interaction partners:
- Lactamase_B domain-containing protein.
- Glutamyl-tRNA
- Bifunctional glutamate/proline--tRNA ligase
- acylglycerol lipase
- Lipase_3 domain-containing protein.
- Lysophosphatidylserine lipase ABHD12
- N-acylethanolamine-hydrolyzing acid amidase
- G protein-coupled receptor 55
- Transient receptor potential cation channel subfamily V member 1
- Aspartyl-tRNA synthetase 2
Sequence:
MTLERLWQVLDPLWADPRVLSALFCGSAMAVVLLKRLGHRRIQQKMEEARRARDLALERMEKAARRFKQENPGTQTAHILSLTMVELAEKLKEGSLSPESVLYSYMGKALEVNREVNCVIDFIHGCEDQLQKVKQQKEKGLLYGIPVSIKDHIDCKGHVSSAGLVKFLGQVKEEDSVIVQVLKSQGAIPFVKTNIPQTMINYDCSNLIFGQTLNPLNHQKTPGGSSGGEGALIAGGGSLLGIGSDVAGSIRLPSSFCGLCGLKPTGFRISKLGVISPITGMNSVIGMLGPIARDVDSLALCMKALLCEEMFRLDPTVPPIPFDEEVYTSSKPLRIGYYEEDGYFQPSPSMKRAVQQTRKLLQEAGHTIVPFAPPKIDYVVDELFTRGIFSDGAAHLVDSFKGDIVDPNLKSQFNTYKLPALVKRILAIILKPIYPRIARDLSALCGVGSAKNLWDQHTAVGLPH
Protein: Protein kinase, putative (Q388A6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDADEGSAPDEEQSMVVDRVALSISDISCMRLDGCRVPSRSSRASHRWSHPQRPHRQPVGDVSSSLSHAASQGSRTSPPSFVFATRVCRSFDSVSQSGGVFDSVVRNHDGESVRSNSEVVKHNTCLEHSQKTCLSSVSLPPLSEACRGHEVSYGLSRRRMSFTSSFSPLPCSPVPKELSPGLLTSIPWNLPTLGWKGMTPTASNVHEGQATNYGEEQCGERVANDTRAYRILNMSNSGGAVATDASVSRERWFHVQHQSFRKRYIGHLNCVYAIYRSLVPRNSPPAASQNISLGDTPTLDRRVRSVALSSASTVTGVAAGYYTLSDSASTRCSGGQNVPVVPRAVRGFSPRRRGRQRALSSREMDPFILGLIKRRVLFRTTIFCEYTYNCIKHSEELRLSSSEIVEPYTEQEYAVSSHSQNGSAFTTSVGRAESDRVATSASDGSSSIFFDDTHRTAPPPGNDGKRRTSVVSPPHEETPMAVHHRTLTRLQTLTTKVHSVDRVMRTVDNEEDDLVVYVGMILMGWLEVVDLLGSGTFGQVFLCKDLRIANKTFVHPSQIEGDDFQYWQCSHTYIPFGDPSMVPTHTPLVAVKVVKSRELFEQQSAREAEILVHVSSQTASQEEQPAEEQQAFPALSFSDPPVPDYRCEYVGKILAHGICYGHHCIVMERYGVNLFEYAMARGFKGLPMYQIQDIGRKILLGLTLLHEECHVVHCDIKPENVLITLDSWLSANPVHMALTVGAHTPGSGASGAISLDASAGQLHQSLRWPASNGLPPLSDSKLPNGAVHSPTPRRMQIAASTERMSMSSILREVAPAGSAAASSPGLNNGAEDDPNLPRIPASPSLLPLNIKLIDFSSSSYIGKGIHTYVQSRYYRAPEVIVGAGYGPAIDVWSTGCLLAELLLGLPLLPGDSDHHQLSLIEEMLGPLPLSLLAKGAATLEYYDVDDVELRSESAGASASEETPAGHKKSPSFRLLSEEEYLRHHRDAKPTKGKRYFQFHTLAELIRKCTASNEERCIATGYSPSAAMDANVMEMVSTQQPRKEIADEISRHRFRFYDLLKKMLHGDPERRLTAREALAHSFFQETPKYLQVYSQR
Protein: Eukaryotic translation initiation factor 3 subunit F (eIF3f) (O43060)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005, ECO:0000269|PubMed:15904532, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit A
- Probable eukaryotic translation initiation factor 3 subunit J
- Eukaryotic translation initiation factor 3 subunit E
Sequence:
MALGTKHVLHLTKPSSRSSPLNIVIEPAVLFSILDHSTRKSENNQRVIGTLLGTRSEDGREIEIKSCFAVPHNESSEQVEVEMEYHRAMYHLHLKANPREVVVGWYATSPDLDAFSALIQNLYASPAEPGTAPLGTYPHPCVHLTVNTDVSSPLAIKTYVSSPVGITERLADSCAFVPTPFTIRDDEAVRSGLKAVAAPKNDPSRLASLFTDLQQLRRSTLELLSMIERVSDYVQNVIDGSSPANVAVGRYLMKCFSLIPCVEGQDFEKIFSSHLQDVLVVVYLANTLRTQVDIASRLNLLP
Protein: Surfeit locus protein 1 (Q15526)
Organism: Homo sapiens (Human)
Function: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P09925}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Heme A synthase COX15
- Protoheme IX farnesyltransferase, mitochondrial
- Protein SCO2 homolog
- Protein SCO1 homolog
- Surfeit locus protein 2
- Surfeit locus protein 4
- Cytochrome c oxidase assembly factor 3 homolog, mitochondrial
- Cytochrome c oxidase assembly protein COX14
- Cytochrome c oxidase assembly protein COX11
- Cytochrome c oxidase subunit 2
Sequence:
MAAVAALQLGLRAAGLGRAPASAAWRSVLRVSPRPGVAWRPSRCGSSAAEASATKAEDDSFLQWVLLLIPVTAFGLGTWQVQRRKWKLNLIAELESRVLAEPVPLPADPMELKNLEYRPVKVRGCFDHSKELYMMPRTMVDPVREAREGGLISSSTQSGAYVVTPFHCTDLGVTILVNRGFVPRKKVNPETRQKGQIEGEVDLIGMVRLTETRQPFVPENNPERNHWHYRDLEAMARITGAEPIFIDANFQSTVPGGPIGGQTRVTLRNEHLQYIVTWYGLSAATSYLWFKKFLRGTPGV
Protein: G-protein coupled receptor 182 (O15218)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Pro-adrenomedullin
- Beta-arrestin-2
- Beta-arrestin-1
Sequence:
MSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS
Protein: Ras-like protein rasC (EC 3.6.5.2) (P32253)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Ras guanine nucleotide exchange factor C
- Ras guanine nucleotide exchange factor A
- Protein kinase 2
- Probable serine/threonine-protein kinase roco5
- Rac guanine nucleotide exchange factor B
- Uncharacterized protein
- Neurofibromin-A
- Protein pianissimo A
- RAC family serine/threonine-protein kinase homolog
- Ras guanine nucleotide exchange factor S
Sequence:
MSKLLKLVIVGDGGVGKSALTIQLTQNQFIAEYDPTIENSYRKQVNIDEEVYMLDILDTAGQEEYSAMRDQYIRSGRGFLIVYSIISRASFEAVTTFREQILRVKDLSTYPIVIIGNKADLPDKDRKVPPMEGKELAKSFGAPFLETSAKSRVNVEEAFFTLVREIKRWNQNPQNEEMLPPKKRGCIIL
Protein: Protein arginine N-methyltransferase 1.1 (AtPRMT11) (EC 2.1.1.319) (Arginine methyltransferase pam1) (Histone-arginine N-methyltransferase PRMT11) (Q9SU94)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain. Type I arginine methyltransferase active on both histones and non-histone proteins. Required for leaves and flowers development. Mediates the methylation of MBD7 and MED36A.
Subcellular location: Nucleus. Cytoplasm. Note=Excluded from nucleolus.
Interaction partners:
- Histone H4
- Small ribosomal subunit protein uS5x
- rRNA 2'-O-methyltransferase fibrillarin 2
- Lysine-specific demethylase JMJ18
- Methyl-CpG-binding domain-containing protein 8
- Protein arginine N-methyltransferase 1.5
- Bystin
Sequence:
MTKNSNHDENEFISFEPNQNTKIRFEDADEDEVAEGSGVAGEETPQDESMFDAGESADTAEVTDDTTSADYYFDSYSHFGIHEEMLKDVVRTKTYQNVIYQNKFLIKDKIVLDVGAGTGILSLFCAKAGAAHVYAVECSQMADMAKEIVKANGFSDVITVLKGKIEEIELPTPKVDVIISEWMGYFLLFENMLDSVLYARDKWLVEGGVVLPDKASLHLTAIEDSEYKEDKIEFWNSVYGFDMSCIKKKAMMEPLVDTVDQNQIVTDSRLLKTMDISKMSSGDASFTAPFKLVAQRNDYIHALVAYFDVSFTMCHKLLGFSTGPKSRATHWKQTVLYLEDVLTICEGETITGTMSVSPNKKNPRDIDIKLSYSLNGQHCKISRTQHYKMR
Protein: CagY protein (E0WK31)
Organism: Helicobacter pylori (Campylobacter pylori)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MNEENDKLETSKKTQQHSPQDLSNEETIKANHFEDSSKESKESSDHHLDNSTETETNFDGDKSEETQTQMDSGGNETSESSNLADKLFKKARKLVDNKRPFTQQKNLDEEIQEPNEEYDQENNGYQEETQMDLIDDETSKKTQQHSPQDLSNEETIKANHFEDSSKESKESSDHHLDNSTETETNFDGDKSEETQTQMDSGGNETSESSNLADKLFKKARKLVDNKRPFTQQKNLDEEIQEPNEEYDQENNGYQEETQMDLIDDETSKKTQQHSPQDLSNEETIKANHFEDSSKESKESSDHHLDNSTETETNFDEYKSEEITNDSNDQEIIKGSKKKYIIGGIVVAVLIVIILFSRSIFHYFIPLEDKSSRFSKDRNLYVNDEIQIRQEYNRLLKERNEKGNMIDKNLFFNDDPNRTLYNYLNIAEIEDKNPLRAFYECISNGGNYEECLKLIKDKKLQDQMKKTLEAYNDCIKNAKTEEERIKCLDLIKDENLKKSLLNQQKVQVALDCLKNAKTDEERNECLKLINDPEIREKFRKELELQKELQEYKDCIKNAKTEAEKNECLKGLSKEAIERLKQQALDCLKNAKTDEERNECLKNIPQDLQKELLADMSVKAYKDCVSKARNEKEKKECEKLLTPEAKKKLEQQVLDCLKNAKTDEERKKCLKDLPKDLQNDILAKESLKAYKDCVSQARTEAEKKECEKLLTPEAKKLLEEEAKESVKAYLDCVSQARTEAEKKECEKLLTPEAKKKLEEAKKSVKAYLDCVSQAKTEAEKKECGKLLTPEARKLLEQQVLDCLKSAKTDEERKKCLKDLPKDLQKKVLAKESVKAYLDCVSQAKNEAEKKECEKLLTPEAKKLLEEAKESLKAYKDCVSQARTEAEKKECEKLLTPEAKKLLEEEAKESVKAYLDCVSQAKTEAEKKECEKLLTPEAKKKLEEAKKSVKAYLDCVSQAKTEAEKKECEKLLTPEARKLLEQEVKKSVKAYLDCVSRARNEKEKKECEKLLTPEAKKKLEEAKKSVKAYLDCVSQAKTEAEKKECEKLLTPEARKLLEQEVKKSVKAYLDCVSRARNEKEKKECEKLLTPEAKKLLEQQALDCLKNAKTEAEKKRCVKDLPKDLQKKVLAKESVKAYLDCVSRARNEKEKKECEKLLTPEARKLLEEAKESLKAYKDCLSQARNEEERKACEKLLTPEARKLLEQEVKKSVKAYLDCVSRARNEKEKQECEKLLTPEARKFLAKQVLSCLEKARNEEERKACLKNIPKDLQKNVLAKESLKAYKNCLSQARNEEERKACEKLLTPEARKLLEQEVKKSVKAYLDCVSRARNEKEKQECEKLLTPEARKFLAKELQQKDKAIKDCLKNADPNDRAAIMKCLDGLSDEEKLKYLQEAREKAVLDCLKTARTDEEKRKCQNLYSDLIQEIQNKRTQSKQNQLSKTERLHQASECLDNLDDPTDQEAIEQCLEGLSDSERALILGIKRQADEVDLIYSDLRNRKTFDNMAAKGYPLLPMDFKNGGDIATINATNVDADKIASDNPIYASIEPDITKQYETEKTIKDKNLEAKLAKALGGNKKDDDKEKSKKSTAEARVESNKIDKDVAETAKNISEIALKNKKEKSGEFVDENGNPIDDKKKTEKQDETSPVKQAFIGKSDPTFVLAQYTPIEITLTSKVDATLTGIVSGVVAKDVWNMNGTMILLDKGTKVYGNYQSVKGGTPVMTRLMIVFTKAITPDGVIIPLANAQAAGMLGEAGVDGYVNNHFMKRIGFAVIASVVNSFLQTAPIIALDKLIGLGKGRSERTPEFNYALGQAINGSMQSSAQMSNQILGQLMNIPPSFYKNEGDSIKILTMDDIDFSGVYDVKITNKSVVDEIIKQSTKTLSREHEEITTSPKGGN
Protein: PNPLA domain-containing protein (Q386C0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPLPTDPREWVKKVRAKTPVLLEVGKPAPKAVLSFGGCGFLVTYSLGVALYLQQEKADLLAQSFLLGAGAGVIPAVALACGARAVNIEKVRDAILDNRFMVTDEERRIEVLTKFINLLLPRNAVELVSGRLALTIGFSNRDPGYMKQTKEQIHFGHHVAQWTDVSDLAQCILASMAPNTAKPMIFRDADNVMRGTMMSLSSELDQYCRHIYIHGYCGYPYNKHQTRHNIYFGRHGFLANTYFPFWKQALLAFAPTFGGAARREELLEAYDAGYNDARRYERWEEDPYHFSKADRSPSDDFSFRQLRANLFGGKKAAERFEL
Protein: Phosphoinositide 3-phosphatase (EC 3.1.3.64) (Yeast myotubularin-related protein 1) (P47147)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P). Involved in the control of PI3P-dependent signaling and in the maintenance of endosomal system integrity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Phosphatidylinositol-3-phosphatase SAC1
- Polyphosphatidylinositol phosphatase INP53
- Polyphosphatidylinositol phosphatase INP52
- Polyphosphoinositide phosphatase
- Phosphatidylinositol 3-kinase VPS34
- 1-phosphatidylinositol 3-phosphate 5-kinase FAB1
- Phosphatidylinositol 4-kinase STT4
- Phosphatidylinositol 4-kinase LSB6
- Phosphatidylinositol 4-kinase PIK1
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Sequence:
MEYIKIAKVSNVVLHRRGTATQGTLHLTTHHLIFESPQLSTEFWFPYPLIYGVHKNPGSTLLSKLTSTNQIQLEGTDSQNYKLYQGKDLWSFVNIKVIGKDYAVFSLDFGGDLHLQARKVYDSILNLTVLSNITQLYAFIYISNNLERKLPSPDSWDIYDPIKEFRRQGLDSKDETCPWRLSTVNEHYEFCPTYPSKLFVPRSTSDILLKHASKFRSQKRIPVLTYHHKATDCNILRSSQPLPGLINQRSIQDEKLVWESFNSFCNKDIRRTKHVIVDARPRTNALAQMALGGGTENMDNYNFFLADNNMGVDKSLKLPTVTRLFLGIDNIHIVSNTAAYMTEVICQGGDLNLPLEQNLIRSQKFSNWLKLNTLILKSVDMLLKSIIFNHSNVLVHCSDGWDRTSQVVSLLEICLDPFYRTFEGFMILVEKDWCSFGHRFLERSGHLNSDIRFHDNTMHSNFNDVDTNGDDLDIGVNTQDDYAEDDEGGEDETNLINLSRISKKFNENFKLNKKSLKFVSPVFQQFLDCVYQLLTQNPDLFEFNERFLRRLVYHLYSCQYGTFLSNSEKEKFQQNLPNKTKSVWDYFRSRRKQFINPNFIQRKRSGMNEHDQNLEEEEKVEWISPDLKKVQWWWQLYGRKDSEMNDELRHKRDSVPISVDKKSKEHSNSDGGKGLNLSIFGFDMFNRK
Protein: HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) (Q53T59)
Organism: Homo sapiens (Human)
Function: May be a modulator of IL-2 signaling.
Interaction partners:
- Calcineurin B homologous protein 1
- Cystinosin
Sequence:
MQSPAVLVTSRRLQNAHTGLDLTVPQHQEVRGKMMSGHVEYQILVVTRLAAFKSAKHRPEDVVQFLVSKKYSEIEEFYQKLSSRYAAASLPPLPRKVLFVGESDIRERRAVFNEILRCVSKDAELAGSPELLEFLGTRSPGAAGLTSRDSSVLDGTDSQTGNDEEAFDFFEEQDQVAEEGPPVQSLKGEDAEESLEEEEALDPLGIMRSKKPKKHPKVAVKAKPSPRLTIFDEEVDPDEGLFGPGRKLSPQDPSEDVSSVDPLKLFDDPDLGGAIPLGDSLLLPAACESGGPTPSLSHRDASKELFRVEEDLDQILNLGAEPKPKPQLKPKPPVAAKPVIPRKPAVPPKAGPAEAVAGQQKPQEQIQAMDEMDILQYIQDHDTPAQAAPSLF
Protein: Insertion element IS1 2 protein InsB (IS1b) (P0CF26)
Organism: Escherichia coli (strain K12)
Function: Absolutely required for transposition of IS1.
Interaction partners:
- Insertion element IS1 2 protein InsA
- Insertion element IS1 1 protein InsA
- Insertion element IS1 7 protein InsA
- Insertion element IS1 4 protein InsB
- Insertion element IS1 1 protein InsB
- Transposase InsE for insertion sequence IS3A
Sequence:
MPGNRPHYGRWPQHDFPPFKKLRPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVEQHDKVIGHYLNIKHYQ
Protein: Copper amine oxidase-like protein cao2 (EC 1.4.3.21) (O42890)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Copper amine oxidase-like protein that does not show any copper amine oxidase activity. May be the appropriate amine substrate for cao2 has not been identified yet.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative aldehyde dehydrogenase-like protein C9E9.09c
- Putative aldehyde dehydrogenase-like protein C922.07c
- Copper amine oxidase 1
- Probable catechol O-methyltransferase 2
- Probable catechol O-methyltransferase 1
- Glutathione-independent glyoxalase hsp3102
- Putative glutathione-independent glyoxalase hsp3105
- Glutathione-independent glyoxalase hsp3101
- Lactoylglutathione lyase
- Probable glutathione-independent glyoxalase hsp3103
Sequence:
MAEESKAAEYFDPLDPLSFNELRYVVNLVRKSYPEKQISFDVVTLSEPHKEEYVHWRYSSAHEGIPDRRAYVIVLEKEVPGVFEGIVNLTTGKIEKWEHSVDTCPIITADLLAITDEIVRNDANVIEQCKICGVPESGLSNVYCDPWTIGYDERYGSGRRLQQALMYYKPGDSGHLRSIPLDFCPIIDVDQKKVIAIDIPKVRRPIPQDVNSDNNLKKLEQEMEAMKMLKPLRITQPEGVNFRIKGRYIEWQNFCFHIGFNYREGIVLSDVVFNEDGHLRPLFYRISLTEMAVPFGAKGHSHHRKHAYDLGEYGVGYRTNPLSFTCGCEGVIHYMDADFVNYRGEITTIKNAISIHEEDDGVLFKYSDLRDRNANISARSIKLVVSQVFTAANYEYLVYWIFRMDGVIECEIRLTGILNTNAINEDEDLKGHGTQVYPKISAENHEHLFCLRINPMLDGLRNSVATVDALRDKNGTLVSKYIIPETVTEAISNYDSSTGRTWDICNLNKLHPYSGKPVSYKLISRDTSPVLSQPGTTNSDCSGFAENNIYVTPYMDDQIFPTGDYAPQASDDTPKGLSKWISDDPNAQIKNTDIVVWHTFGMIHFPAPEDFPIMPAESIHLFLQPRNFFKHNPALDTSSSVNSTSEATSPNTHHENLRDTSQKRESHSTPHDYEPHVSDKNDKSVEDKLHFVQKDESRPKEPVVDAAQKHEGRSETLAQPGQQNANQSEEKQGGQNGSNGGHHHHHHHHYITGHVYGGYHKHSGSGGHLVDMMKNISDVTHDFAMGNFRYHKYD
Protein: Hsp90 co-chaperone Cdc37 (Cell division control protein 37) (Hsp90 chaperone protein kinase-targeting subunit) (Q8X1E6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Heat shock protein 90 homolog
- Hsp90 cochaperone
- Co-chaperone
- Hsp90 cochaperone
- Aha1p
- Serine/threonine-protein phosphatase
- Flavin reductase like domain-containing protein
- Uncharacterized protein
- Peptidyl-prolyl cis-trans isomerase D
- Cyclin-dependent kinase 1
Sequence:
MPIDYSKWDKIEISDDSDVEVHPNVDKQSFIRWKQRDIHEKRMQRNIEIKSILIQLTMYAKLNERVDYLLEKLTSTELLDSEKVMSKLNSEFDPQEKFDYDKLIKDKGSTLRKGLKDLKFDREEIENTPCYNEMIEDLFVQIKDDHPETKTDGDKLIEYLKEHRNRIDDVLSKQTIKLDDLLYQKAQLIVSDDLHTGFDRSFLNKDKPEEKEENQDKPKAPEAKKTTVTTTETINSPKPVEENTDKEILDELEILPATKEFAKIPSDNLSKAAEFLIKHPSICTEQQKDALIMTAFDLQLENKSDEAKHIVHQSLLLQYVGQLSDNGKAAPANVINAIKLFFSKIAAESSPAKHAFLEDVNQTFNHIKGRCEIIKEEQKQNAANKEGTGEEEEEEALIQLKALDDNTELSVNIPQEGTKEYEIFTTKLPIEFQNAIKTESIDEVNKEFAKLKIEDAERILEIFNECGVIGISGYIEDEKEFEELKKEYAHETANQEEDQSASVEDTVD
Protein: Desmin b (Zgc:154009) (Q05AI8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSHSYASSSSSSSYRRMFGGPGYMTPPMSRGVFGRASTGGSGSSRVSSRVYEVSKSSTSSPGFSGYRASSYSMPNLSAGYTRSYGGMGETLDFSLADALNQEFLHTRTNEKAELQHLNDRFANYIEKVRMLEQQNQVLGVEVERLRGREPTRIADLYEDEMRELRREVEVVTNHRSRVEVERDNLADDLQKLKLRLQEEIALREEAENNLSAFRADVDAATLARLDLERRIETLQEEIAFLKKIHEEEIRELQAQMQETQVQIQMDMSKPDLTAALRDIRAQYEGIAAKNIAEAEDWYKSKVSDLNQAVSKNNEALKQSKLETMEYRHQIQSYTCEIDSLKGSNESLMRQMRDMEDRHGREAGALQDTIARLEAEIANMKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRIVMPMQSYSTISFRETSPEHQQRASEMHSKKTVLIKTIETRDGEVVSESTQHQQDLM
Protein: Cyclin-dependent kinase 5 activator (Q9V3H5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cyclin-dependent kinase 5 homolog
- P53, isoform B
- VhaAC45-related protein, isoform B
Sequence:
MGTVLSFNPRDRHPIYSSQPNFQYNHSTDMRNENDSTGSIDSHLNNFSYEQLNNAKNRENKKSACHPMAKNVIGQPGGQCGGVHINLQTQTQLSSHNLNNLANASKDTITNVLDTHNENSVLKAEKSSFEKNLKKHSIFINALSWKKLSTSHNKKKIENKNKCANLPTACFKAQLLESSFASSSDKNRNIQLHCNRIDEHNQQHCNQHPHPHPHQHQLQLQNQHQHQNQNQNQNQNQVQDIREEVMTGPPGKSQNPSKAKDPVKVNNKNSMSNHNKLIQKQPLTLSLPQQVQASSIQTKNTNQIPRKTVIQASTSELLKCLGMFLHCRCQRLNNFDAGDAVMWLRAVDRSLLLQGWQDVAFINPANVVFVYMLVRELVSGEESKESDLQASVLTCLYLSYSYMGNEISYPLKPFLVEDSKEKFWDRCLVIVNKLSDKMLKINAEPGFFTEVFTELKSCGQYHPTIKSYCGGA
Protein: Interferon kappa (IFN-kappa) (Q9P0W0)
Organism: Homo sapiens (Human)
Function: May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.
Subcellular location: Secreted.
Interaction partners:
- Interferon alpha/beta receptor 1
- Interferon alpha/beta receptor 2
- Interferon alpha-1/13
- Interferon lambda receptor 1
- Interleukin-10 receptor subunit beta
- Interferon gamma receptor 1
- Interleukin-12 receptor subunit beta-1
- Interferon lambda-1
- Interferon epsilon
- Interferon lambda-2
Sequence:
MSTKPDMIQKCLWLEILMGIFIAGTLSLDCNLLNVHLRRVTWQNLRHLSSMSNSFPVECLRENIAFELPQEFLQYTQPMKRDIKKAFYEMSLQAFNIFSQHTFKYWKERHLKQIQIGLDQQAEYLNQCLEEDKNENEDMKEMKENEMKPSEARVPQLSSLELRRYFHRIDNFLKEKKYSDCAWEIVRVEIRRCLYYFYKFTALFRRK
Protein: Transcription factor YY2 (Yin and yang 2) (YY-2) (Zinc finger protein 631) (O15391)
Organism: Homo sapiens (Human)
Function: Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Membrane-bound transcription factor site-2 protease
- E3 ubiquitin-protein ligase RING2
- E3 ubiquitin-protein ligase RING1
- Transcriptional repressor protein YY1
- Polycomb complex protein BMI-1
Sequence:
MASNEDFSITQDLEIPADIVELHDINVEPLPMEDIPTESVQYEDVDGNWIYGGHNHPPLMVLQPLFTNTGYGDHDQEMLMLQTQEEVVGYCDSDNQLGNDLEDQLALPDSIEDEHFQMTLASLSASAASTSTSTQSRSKKPSKKPSGKSATSTEANPAGSSSSLGTRKWEQKQMQVKTLEGEFSVTMWSPNDNNDQGAVGEGQAENPPDYSEYLKGKKLPPGGLPGIDLSDPKQLAEFTKVKPKRSKGEPPKTVPCSYSGCEKMFRDYAAMRKHLHIHGPRVHVCAECGKAFLESSKLRRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHLRIHTGDKPFVCPFDVCNRKFAQSTNLKTHILTHVKTKNNP
Protein: Large ribosomal subunit protein eL21 (60S ribosomal protein L21) (P46778)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P49666}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P49666, ECO:0000269|PubMed:25957688}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS15
- Ubiquitin-ribosomal protein eS31 fusion protein
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein eL22
- Ubiquitin-like protein FUBI
Sequence:
MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA