wanglab/gogpt-training-data huggingface dataset:
Protein: DNA replication complex GINS protein PSF1 (GINS complex subunit 1) (Q14691)
Organism: Homo sapiens (Human)
Function: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Subcellular location: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
Interaction partners:
- DNA replication complex GINS protein PSF3
- Cell division control protein 45 homolog
- DNA replication licensing factor MCM3
- DNA replication complex GINS protein PSF2
- DNA replication licensing factor MCM2
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM5
- DNA replication complex GINS protein SLD5
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM6
Sequence:
MFCEKAMELIRELHRAPEGQLPAFNEDGLRQVLEEMKALYEQNQSDVNEAKSGGRSDLIPTIKFRHCSLLRNRRCTVAYLYDRLLRIRALRWEYGSVLPNALRFHMAAEEMEWFNNYKRSLATYMRSLGGDEGLDITQDMKPPKSLYIEVRCLKDYGEFEVDDGTSVLLKKNSQHFLPRWKCEQLIRQGVLEHILS
Protein: TELO2-interacting protein 2 (Q6NXR4)
Organism: Homo sapiens (Human)
Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.
Interaction partners:
- Telomere length regulation protein TEL2 homolog
- TELO2-interacting protein 1 homolog
- RuvB-like 2
- RuvB-like 1
- RNA polymerase II-associated protein 3
- PIH1 domain-containing protein 1
- Heat shock protein HSP 90-beta
- Heat shock protein HSP 90-alpha
- Transformation/transcription domain-associated protein
Sequence:
MELDSALEAPSQEDSNLSEELSHSAFGQAFSKILHCLARPEARRGNVKDAVLKDLGDLIEATEFDRLFEGTGARLRGMPETLGQVAKALEKYAAPSKEEEGGGDGHSEAAEKAAQVGLLFLKLLGKVETAKNSLVGPAWQTGLHHLAGPVYIFAITHSLEQPWTTPRSREVAREVLTSLLQVTECGSVAGFLHGENEDEKGRLSVILGLLKPDLYKESWKNNPAIKHVFSWTLQQVTRPWLSQHLERVLPASLVISDDYQTENKILGVHCLHHIVLNVPAADLLQYNRAQVLYHAISNHLYTPEHHLIQAVLLCLLDLFPILEKTLHWKGDGARPTTHCDEVLRLILTHMEPEHRLLLRRTYARNLPAFVNRLGILTVRHLKRLERVIIGYLEVYDGPEEEARLKILETLKLLMQHTWPRVSCRLVVLLKALLKLICDVARDPNLTPESVKSALLQEATDCLILLDRCSQGRVKGLLAKIPQSCEDRKVVNYIRKVQQVSEGAPYNGT
Protein: Mitochondrial inner membrane m-AAA protease component yta12 (EC 3.4.24.-) (EC 3.6.-.-) (Q9HGM3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides (By similarity).
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Lon protease homolog, mitochondrial
- Prohibitin-1
- Uncharacterized protein C13E7.11
- Large ribosomal subunit protein uL2m
- Putative monoglyceride lipase
- Large ribosomal subunit protein uL13m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein uS14m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL27m
Sequence:
MRNPFLTFRAPTRKTGDYLVSKFVKKDNFSSLRLARAYTFSTRSTAVSQFSLLSLSQRSFQSLKINKGIPEKHKIPLISSKQFSVTSKRSQNGSSGSNSDANGRKNGQKNDDSKKKGLNGNDPKKVFEIALNGNTILGGILVAYILYNVLSPNANMQEITWQDFRQQFLDKGLVERLVVVNRNMVRVILRGGVASGSGQYYFSIGSIDSFDRKLEDAQRQLGIPPSEFVPVAYHDEVSVLATLLSFAPTLLIIGSVIYLSRRASGAAGGGQGGIFGIGKSRAKMFNHETDIKIKFADVAGVDEAKEEIMEFVKFLKNPKFYERLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPFLSVSGSEFLEMFVGVGPSRVRDLFATARKNAPCIIFIDEIDAIGKARGRGGQFGSNDERESTLNQLLVEMDGFTSSEHIVVFAGTNRPDVLDPALLRPGRFDRQITIDRPDIGGREQIFKVHLKHIKAADNIDLIAKRLAVLTSGFTGADIMNVCNEGALIAARSNSNEVQMVHFEQAIERVTAGLEKKSRVLSPEEKNTVAHHEAGHAVAGWFMEYVDPLLKVSIIPRAQALGYASYLPKDQYLMSRGQILDQMGMALAGRVSEEIFFGPEKITSGASDDFQKVTRMAQAYVTQYGMSPTVGTIAYPIDTRETVQKPFSEATAQMIDEEIRKLVKHAYERTKKLLLEHKQGLENIAQRLLQKEVITYNEVETILGPRPYAYKHLNISELMRQSEYKNDHDPRNPPIPPSPQQPSA
Protein: Interleukin-1 (A3DTN2)
Organism: Anas platyrhynchos (Mallard) (Anas boschas)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Lysosome {ECO:0000256|ARBA:ARBA00004371}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
Interaction partners:
Sequence:
MAFVPDLDVLESSSLSEETFYGPSCLCLQKKPRLDSEHTTVDVQVTVRKGRGARSFRRAAVLVVAMTKLLRRPRSRDFADSDLSALLEEVFEPVTFQRLESSYAGAPAFRYTRSQSFDIFDINQKCFVLESPTQLVALHLQGPSSSQKVRLNIALYRPRGPRGSAGTGQMPVALGIKGYKLYMSCVMSGTEPTLQLEEADVMRDIDSVELTRFIFYRLDSPTEGTTRFESAAFPGWFICTSLQPRQPVGITNQPDQVNIATYKLSGR
Protein: Inhibitor of Bruton tyrosine kinase (E9PDR5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
Protein: DExH-box ATP-dependent RNA helicase DExH1 (EC 3.6.4.13) (F4ILR7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g31870
- AT3g15090/K15M2_24
- ATP-dependent DNA helicase At3g02060, chloroplastic
- DEAD-box ATP-dependent RNA helicase 28
- Chloroplastic group IIB intron splicing facilitator CRS2-A, chloroplastic
- Chloroplastic group IIB intron splicing facilitator CRS2-B, chloroplastic
- Peptidyl-tRNA hydrolase, chloroplastic
- DEAD-box ATP-dependent RNA helicase 26
- DExH-box ATP-dependent RNA helicase DExH18, mitochondrial
- AP-2 complex subunit sigma
Sequence:
MPPHGPNSQGGRRGGGHSSGRRGGRGGGGRGGGGGGRGEQRWWDPVWRAERLRQQQAEMEVLDENEWWNKIEQWKTGGEQEMLIKRNFSRGDQQTLSDMALQMGLYFHAYNKGKALVVSKVPLPDYRADLDERHGSTQKEIKMSTETERKLGSLLKTTQESGSSGASASAFNDQQDRTSTLGLKRPDSASKLPDSLEKEKFSFALKERQEKLKATESVKALKAFREKLPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSLRGADCNIICTQPRRISAISVASRISAERGESIGESVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSATINADMFSTYFGNSPTMHIPGFTFPVAELFLEDVLEKSRYNIKSSDSGNYQGSSRGRRRESESKKDDLTTLFEDIDINSHYKSYSSATRNSLEAWSGAQIDVDLVEATIEHICRLEGGGAILVFLTGWDEISKLLEKINMNNFLGDSSKFLVLPLHGSMPTVNQREIFDRPPPNKRKIVLATNIAESSITIDDVVYVVDCGKAKETSYDALNKVACLLPSWISKASAHQRRGRAGRVQAGVCYRLYPKVIYDAFPQYQLPEIIRTPLQELCLHIKSLQVGSIGSFLAKALQPPDALAVENAIELLKTIGALNDVEELTPLGRHLCTLPVDPNIGKMLLIGAIFQCVNPALTIAAALAYRSPFVLPLNRKEEADEAKRYFAGDSCSDHIALLKAYEGYRDAKRGGNEKDFCWQNFLSPVTLRMMEDMRNQFLDLLSDIGFVDKSKPNAYNQYSYDMEMISAVLCAGLYPNVVQCKRRGKRTAFYTKELGKVDIHPGSVNARVNLFSLPYLVYSEKVKTTSVYIRDSTNISDYALLMFGGNLIPSKTGEGIEMLGGYLHFSASKNILELIQRLRGEVDKLLNKKIEDPSLDITVEGKGVVSAVVELLRSQKH
Protein: Histone deacetylase complex subunit SAP130b (EC 3.2.1.3) (Sin3A-associated protein b) (B0S8H2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Family with sequence similarity 60, member A
- Paired amphipathic helix protein Sin3a
- Paired amphipathic helix protein Sin3b
- Paired amphipathic helix protein Sin3a
- SDS3 homolog, SIN3A corepressor complex component)
Sequence:
MNSQQYPRPGLPSGLGQGQTAGNNTAGFPGSQKSTGHEDSNHAPRELMSSGATVFRDDKQETVVVRPYPQPQMQPPSHGAAPTLPPPLPQHLPIQPVSVSAAPSHLPQGLSLAFTEGSLKSALKAPMSSRVIAPAPVPTPSHLTLPPKVPGHLTATMESTQASGIPVATISGQQGHSGNLHHLMTSVQIIRSGAPVQQIGSSAAPQHCFPSHLPRGAAAAAVMSSSKGATGLRPAAGPSSATGQPTVQHIIHQPIQSRPIVTTSTAVLPTVVAPVTATRPQSPVITTVAAHSGDMVHGRSAVAIHPPQATLSIQRPPPSRDTPTRITLPSHPAIAAQKALSHSVAQKPIFSTVTPVAAATVAPIQVTNTAPSPTTTGSTPHTQISNSNIVTMTVASHSSHATAVTTSTIPVAKVVPQPITHTSPRIQSEYTERGNLIPISGHRSSPNPITMENRTDNRQSVPVQFQYFLPTYQSAPYPLTHTYTPITSSVSSIRPYPVTAQAPSAAMPTQAGVGVASAVHLNSMQLMTVDRITQINTQNIQPGAMTAQGIQPTPIPAQNLHTSAQITTPSIQPSPVNQQQPPTESKASVVLADGSTLMANSISNAFSNSQPTTTLAQTHIQNANTGTPSLVTSPRPSILRKKPANEGAAVRKNLIPAQLGDTTAPRIDGPIRSASGSPRPAGVKPKPDIHMSLAPSVAAAIEAIPSQGTEQQAQHVGPPSSQLASQPLPSLLASVTPPSLPAPALSALPAAMTVTQPIPSMTNVVAQPIQPAANNTSVCTINSNLPELNIKQEPEPMDSSKPVALGPNSGAQMLTVPPTDLTLGASPRKKPRKQQHIISTEESEMMETNSTDEEKFPPKPLSQRAEKRKSPPKEYIDEEGVRYVPARVRPPITLLRHYRNPWKAAYHHFQRYSDVRIKEDKKGSMQDVANQKGVVCRAQGWKIHLCAAQLMQLSNLEHDVYSRLTTLQEGFVPKKKAGADVDLHRINELIQGNMQRCKLVMDQITEARDSMLKVLDHKERVLKLLNKNSSTKKLNKLKRKDRA
Protein: SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) (Q9DA08)
Organism: Mus musculus (Mouse)
Function: Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (By similarity). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (By similarity). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-491'.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P0C606}.
Interaction partners:
- Transcriptional adapter 3
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 10
- Transcriptional adapter 2-alpha
- Transformation/transcription domain-associated protein
- Cysteine-rich protein 2-binding protein
- ZZ-type zinc finger-containing protein 3
- Transcription factor SPT20 homolog
- Histone acetyltransferase KAT2A
- SPT3, SAGA and STAGA complex component
Sequence:
MALVSADSRIAELLTELHQLIKQTQEERSRSEHNLVNIQKTHERMQTENKISPYYRTKLRGLYTTAKTDAEAECNILRKALDKIAEIKSLLEERRIAAKIAGLYNDSEPPRKTMRRGVLMTLLQQSAMTLPLWIGKPGDKPPPLCGAIPASGDYVAKPGDKVAARVKAVEGDEQWILAEVVSYSHATNKYEVDDIDEEGKERHTLSRRRIIPLPQWKANPETDPEALFQKEQLVLALYPQTTCFYRALIHTPPQRPQDDYSVLFEDTSYADGYSPPLNVAQRYVVACKEPKKK
Protein: Autophagy-related 1, isoform A (LP23904p) (Q9VU14)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNIVGEYEYSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCITKKGQLKTQNLLGKEIKILKELTELHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNSKDRISYESFFVHRFLQGKKAAVSPVDMPPLGGTPPAKAKSPLQQQLEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNSGSCSSHEDSDDFVLVPKNLPEDQRQGLAQVQAQPASGGQRPQQQQNQSSPPRPSSLPISEPKPVPAPARRQVARPGPLTVATLGGQQIPRSQPISVKQPRPDQRKSSVSSDINSISPPAVQFAIGTPPTRMRSASGGSLSETPPPHAPSTWQVSPGHSQSPLRRSGNSSPVLPSAALTKLPTLGSPTMLVAPGSLGSIGSAGSGSENNNQHHMLGPRAFTLPELGATGGLHSLLDTGAGGGGEPHAFQAPELSEETLMDREHNETLSKLNFVLALTDCIQEVADSRCAPLSTFMVAGSQSAAQAASADAQQIPPHAPEHCKRAERLVLLVRGLQLLSSGMNLASQQLSNGQLKPSSNVKNALLTMNAKYRSMLFESKRLNGSGLLQKANAFNITADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHILLHSLVQKCNHPQDKMMLNKYRDAVEKRLSILQQHGYIYMTDENA
Protein: AAA-type ATPase family protein (Putative AAA-type ATPase) (Q9ZPW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein RADIALIS-like 6
- GEM-like protein 4
Sequence:
MAASRLCSAAAIAAAFTSMSMSQNRAYADSRFRFPFFSSSPPAEESPTDHKSSSNSKSETKPDSDEPKGSGFDPESLERGAKALREINSSPHSKQVFDLMRKQEKTRLAELAAEKEHNEAIQASKDIERQRKLAEDQRNLVQQQAQAKAQNLRYEDELARKRMQTDNEAQRRHNAELVSMQEASSIRKEKARIATEEQIQAQQRETEKERAELERETIRVKAMAEAEGRAHEAKLTEEQNRRMLLDKINGEREKWLAAINTTFSHIEGGVRTLLTDRSKLIMTVGGVTALAAGVYTTREGARVTWGYINRILGQPSLIRESSMGRFPWAGSVSQFKNKLSTAAGAAASAEGEKPLENVILHRSLKTRIERLARATANTKSHKAPFRNMMFYGPPGTGKTMVAREIARKSGLDYAMMTGGDVAPLGAQAVTKIHEIFDWAKKSNKGLLLFIDEADAFLCERNSTYMSEAQRSALNALLFRTGDQSRDIVLVLATNRPGDLDSAVTDRIDEVIEFPLPGEEERFKLLKLYLNKYLMGDDKKGEKDSNLKWSNLFKKKKSQKITIEGDLTDQVIKEAAKKTEGFSGREIAKLVAGVQAAVYGRQDCVLDSQLFEEIVDYKIEEHHQRIRLATEGGQSFP
Protein: Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3) (Q16720)
Organism: Homo sapiens (Human)
Function: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:18029012, ECO:0000269|PubMed:25953895}; Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q64568}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at parallel fiber terminals. {ECO:0000250|UniProtKB:Q64568}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit gamma
- cGMP-dependent protein kinase 1
- cGMP-dependent protein kinase 2
- G protein-activated inward rectifier potassium channel 4
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Cytochrome P450 11B2, mitochondrial
- Calmodulin-1
- Calmodulin-like protein 3
Sequence:
MGDMANSSIEFHPKPQQQRDVPQAGGFGCTLAELRTLMELRGAEALQKIEEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGKQQDGAMESSQTKAKKQDGAVAMEMQPLKSAEGGEMEEREKKKANAPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVEGRTWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDKLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVRKIIEPMACDGLRTICIAYRDFSAGQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVIATIPTSQLKCLKEAGHGPGKDEMTDEELAEGEEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESKTSIHNFMATPEFLINDYTHNIPLIDDTDVDENEERLRAPPPPSPNQNNNAIDSGIYLTTHVTKSATSSVFSSSPGSPLHSVETSL
Protein: Uncharacterized membrane protein P22H7.04 (Q9C0W3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSMLIFNIRVARHKALLSRIVSTNMFNPMFRSLRPIQKSFSEISILRVFNKPPIKKFHNSNILKDITSKRNATPAKIAWQAMTTREPFLVYQAKADKKISLIYLLTVGMLINVCVITSFASVDIYRAKDEIFANWVDMDYYEKLSYIGSAFITPALYFTLTLILFLPRRNIYSISTLPSQRFEIVTGFLSPFNKLYFSKSLIVPRKDVSIVTYSLQKNPITLKIRDRPFYYLLNANGKYAGNSKDVLFCVIGNRY
Protein: KLLA0F23980p (Q6CIU1)
Organism: Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- KLLA0E01827p
- Enhancer of mRNA-decapping protein 3
- KLLA0F27357p
- ATP-dependent RNA helicase DHH1
- 5'-3' exoribonuclease 1
- NAD
- U6 snRNA-associated Sm-like protein LSm1
- KLLA0A01474p
- KLLA0B11297p
- U6 snRNA-associated Sm-like protein LSm4
Sequence:
MSLPLLRPFETVSLENAVEDLVVRFILNVPPEDLSTVERVLFHFEEASWFYTDFVKLMNPYLPNLSIKSFSKIVIDICPLIWNWDITPENALVKFSNYKKTIPVRGAAIFNDSLSKILLLRGINSKHWSFPRGKIGKDEDDVACCIREVKEETGFDLTGFIDADQYVERNMNGKNFKIFLVKGVPEDFEFKPEHKNEIQAIEWKDFKKLSKAITKNEGSAKVFLVNSMIRPLSLYVKNEKRAKDENKLKLYAEEHLKSILGLNKKENKIVLDAGRELMEMLQKSAKTAQHQARNETYVAENPVVDVNQARSLFPLMSVQSVSHFSSSNNTNNNIVNGTGMTINTTGNNKLDHEKSYSTEQNTDLQASSKELLAFLHKSSTVNDKERQISGSDSVSSFPSAHFTEFTDDENYEEFESSSDESQYESSQEQLGHSDTEWDPNRDDELLTVKEPKSVKETQPSKPVKPETKQGATNNQKPILLKRPESQNKANNIESQTVKPKIRLLRRGDTLASATQSPSNESIKAVSEKRNDTETTSNKNAANDLLSILKKPSEDQPKINDSETHSNRSVANDLLSILKKPSRSEVPGAASSPLFTNTFENSQSSSSNASVEHHTSSNNDRNGSNFSKQFTASPALNEPSPKNDASDLMQLLKRPQQNSEPQSPISDLSPASKPSNELLNILKNPKTGLNSQISDDPVTHNTQYNRMPPLQVQPQQPFQMQQMQQMMPPPGYPPQNMSYIPQGFSPQQQFQYQQPINGYPMQPQPLNMGQPAPNQGFTKQQELLNILHKPNAPVQETPSNPSSELLSILKR
Protein: Dehydrodolichyl diphosphate synthase 1 (Dedol-PP synthase 1) (EC 2.5.1.87) (Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) 1) (O80458)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10764783, ECO:0000269|PubMed:10908715}; Single-pass membrane protein {ECO:0000269|PubMed:10764783, ECO:0000269|PubMed:10908715}.
Interaction partners:
- Farnesyl pyrophosphate synthase 1, mitochondrial
- Farnesyl pyrophosphate synthase 2
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Protein farnesyltransferase subunit beta
- Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 1, chloroplastic
- Dolichol kinase EVAN
- Hydroxymethylglutaryl-CoA synthase
- (Z)-gamma-bisabolene synthase 1 (Terpenoid synthase 12) (AtTPS12)
- Phytoene synthase 1, chloroplastic
- Alpha-humulene/
Sequence:
MLSLLSSDSSLLSLLFLFLIPCLFITSYIGFPVFLLKLIGLIKIKAARDNEKRDEGTYVVREDGLQRELMPRHVAFILDGNRRWAKRAGLTTSQGHEAGAKRLIDIAELCFELGVHTVSAFAFSTENWGRDKIEIDNLMSLIQHYRNKSNIKFFHRSEVRVSVIGNKTKIPESLLKEIHEIEEATKGYKNKHLIMAVDYSGKFDIMHACKSLVKKSEKGLIREEDVDEALIERELLTNCSDFPSPDLMIRTSGEQRISNFFLWQLAYSELFFSPVFWPDFDKDKLLEALASYQRRERRFGCRV
Protein: Phospholipase C, beta 4 (A2AT93)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
NSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEIKKETEIKIQTLTTDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQSAN
Protein: N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) (Q9DCJ9)
Organism: Mus musculus (Mouse)
Function: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
- N-acylglucosamine 2-epimerase
- N-acetylneuraminate-9-phosphate synthase
Sequence:
MAFPKKKLRGLVAATITPMTENGEINFPVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSVSERRQVAEEWVNQGRNKLDQVVIHVGALNVKESQELAQHAAEIGADGIAVIAPFFFKSQNKDALISFLREVAAAAPTLPFYYYHMPSMTGVKIRAEELLDGIQDKIPTFQGLKFTDTDLLDFGQCVDQNHQRQFALLFGVDEQLLSALVMGATGAVGSTYNYLGKKTNQMLEAFEQKDLASALSYQFRIQRFINYVIKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKATQEFTAKAEAKLKSLDFLSSPSVKEGKPLASA
Protein: Mineralocorticoid receptor (C1KB84)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MSLLVMETKGYHSYPEGLDMERRWGQVPQSVEYSSLGPGEQADASNYMEIVNVSCAAGTFANSSAPGNKEKPELLSCLQQDSSHPAVLPSDIKTETESKELSATVAESMGLYMDSIRDADYPYDQQNQGSPGKIYQNVEQLVKLYKENGHCSSPLHSPSRPLRSLMADSGSAMNGGAMHAVVKSPIVCQEKSPSGCSPQNMASSVCSPAGVNSVSSTTANFGNFAMHSPIGQGTPLSRSPNVESRGSMLHSPAHVSNVGSPLSSPISSMKSPISSPPSHCSVKSPVSSPNNITMRSSVSSPANMNSRSSIASPSNANNRSTRSSPAVSTVGGSSICSPVNSSLGFPASSTPAGPSRSQDTVPSPETKDKGAQEIPFPKMEEMENAISNNSQMNLVQFIKPEPDGSFGSACIGENSKISSDCPFSVPVKQESAKHPCSGASFKGNQTVNPFPFTDGSYFSFMDDKDYYSLSGILGPPVSSFDSSCEGSGFPNPGLPVGIKQEPDDGSYYQDSSIPSSAIVGVNSGGQSFHYRIGAQGTISLSRPVAREQAFQHLSSFPPVSTLVETWKSHSELASRRSDGYPVLEYIPENVSSSSLRSVSSGSSRPSKVCLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGMHEEQPQQRQQPPPQSPEEGTTYIAPVTEPPVNTALVPHMSAISPALTPSPVKILESIEPEIVYAGYDSSKPDTAEYLLSTLNRLAGKQMIQVVKWAKILPGFRNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLIFDEERMRQSAMFELCQGMHQISLQFVRLQLSFEEYTIMKVLLLLSTVPKDGLKSQAAFEEMRANYIKELKKMVTKCPSNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNAKPLYFHKK
Protein: Anoctamin (F1QNZ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU280814}.
Interaction partners:
- Phospholipid scramblase
- Phospholipid scramblase
- Phospholipid scramblase
- Phospholipid scramblase
- Phospholipid scramblase
- Phospholipid scramblase
- Phospholipid scramblase
- Phospholipid scramblase
Sequence:
MSETEDNDILEDSDTDGGDVEMADMIDSKTVQTCRTMPKGSDVPIVDFNGNQDFLFFNDGKRRIDFVLVYEYEESKNGSNKKASVIRRKKRRREFFEGSLMNKGLHLEMTQSVVDEKLFFVKLHMPFDVLCANAEVLHIKLPIKCNDLRTQSSKHNCCTKPFYPNEDVIGKEPDYFTAPFRKDLLNRFQLKEREGRELFTPTMRSRMVYYILSRAEYDIKGENKKFGITKLLAGGIYKAAYPLHDCRFNVKSKEEDCPNERYLLYSEWAHPKNFYKMQPLDLIRKYFGEKIGIYFAWLGFYTFMLSLAAAFGLGCFIYGYRSRESSTWSKEVCDPDIGGQIVMCPQCDNNCPYWRLNTTCESSKRLCVFDNFGTLVFAVFMSVWVTLFLEFWKRYQAKLEYKWDTVEFQQQEEQPRPEYEARCTYERFSPITQSNEKVPYTACGKCMRVSCGIGTVLFWILLIVASVVGVIVYRLAMFMVFSMQLRSDLNRKELEPFREYITPQMATSITASIINVIIIMILNIVYEKVAVWITDFELPRTKTEYENSLTLKMFLFQFVNFYSSCFYIAFFKGKIVGYPGEPVYWLGKFRNEECDPGGCLTELTTQLSIIMTGKAVWNNIQEVLLPWLKNLMFRHCTQVGSEKAIPRWEQDYQLQPMGTLGLFYEYLEMVIQFGFVTLFVASFPLAPLLALVNNLFEIRVDAWKFTTQFRRIVPEKAQDIGAWQPILQGVTILAVVTNTAIIAFTSDMIPRLVYYWAFSVSPYVENSNHTMAGFIDSSLSVFNISHFDDKTRPRDDIKPIWFNNITTCRYRDYRNPPDHQNPYQFNVYYWHVIAAKLAFMIVVEHIVYFTKFMLSYLIPDVPEALNEQIKRERFLTRDILNNSQLTDLIKPIREKLQTDVADFTELEELL
Protein: Putative diacyglycerol O-acyltransferase Rv0221 (EC 2.3.1.20) (Putative triacylglycerol synthase Rv0221) (P9WKB7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis.
Interaction partners:
- Enoyl-CoA hydratase EchA19
- Esterase LipC
- Diacylglycerol kinase
- Triacylglycerol lipase
- Possible triacylglycerol synthase
- Probable acyl-CoA dehydrogenase FadE3
- Probable fatty-acid-CoA ligase FadD4
- Possible esterase LipW
- Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1
- Probable integral membrane acyltransferase
Sequence:
MKRLSGWDAVLLYSETPNVHMHTLKVAVIELDSDRQEFGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHIRPWRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVVAKIHHALADGVASANMMARGMDLLPGPEVGRYVPDPAPTKRQLLSAAFIDHLRHLGRIPATIRYTTQGLGRVRRSSRKLSPALTMPFTPPPTFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLAMSTGALRTLLLRYDGKAEPLLASVPVSYDFSPERISGNRFTGMLVALPADSDDPLQRVRVCHENAVSAKESHQLLGPELISRWAAYWPPAGAEALFRWLSERDGQNKVLNLNISNVPGPRERGRVGAALVTEIYSVGPLTAGSGLNITVWSYVDQLNISVLTDGSTVQDPHEVTAGMIADFIEIRRAAGLSVELTVVESAMAQA