wanglab/gogpt-training-data huggingface dataset:
Protein: Synaptotagmin-12 (Synaptotagmin XII) (SytXII) (Q920N7)
Organism: Mus musculus (Mouse)
Function: Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (By similarity). Essential for mossy-fiber long-term potentiation in the hippocampus.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:17190793}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAVDVTEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGEAYVEAKLKRVPPWNDQRTTTRGPPSRKGSLSIEDTFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSMDYDGASHTLHVAVLQGKDLLEREEATFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSVPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQDQNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNEKSTADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPGVSGMGTTHWNQMLATLRRPVSMWHPVRRN
Protein: Ecdysis-triggering hormone (Q9U4J0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRIITVLSVSLLVGLVAISQADDSSPGFFLKITKNVPRLGKRGENFAIKNLKTIPRIGRSEHSSVTPLLAWLWDLDTSPSKRRLPAGESPAKEQELNVVQPVNSNTLLELLDNNAIPSEQVKFVHWKDFDRALQADADLYSKVIQLGRRPDQHLKQTLSFGSFVPIFGDEQNPDFMMYKNNEDQELYGGGNRYDRQFLKYNIL
Protein: Checkpoint kinase 2 (B7ZBF8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIED
Protein: Cytoplasmic linker associated protein 1 (A0A1B0GWM1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Golgi apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
Interaction partners:
Sequence:
MEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVVLLGMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGGFKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLSKKGLPQSRLNVIFTKFDEVQKSGNMIQSANDKNFDDEDSVDGNRPSSASSSSSKAPSSSRRNVSMGTTRRLMASSLGSKSSAAKEGAGAVDEEDFIKAFDDVPVVQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYDNFFQHLRLLDGAFKLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTHIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHLKNSDSIVSLPQSDRSSSSSQESLNRPLSAKRSPTGSTASRGSTVSTKSMSTTGSLQRSRSDIDVNAAASAKSKVSSSSGSTAFSSAAALPPGSYASLESRHMREDLEYVGLDAGRIRTRRQSSGSTTNVASTSSDSRGRSRAKVVSQSQPGSRSSSPGKLLGSGYGGLAGGSSRGPPVTPSSEKRSKIPRSQGCSRETSPNRIGLDRFGLGQSGRIPGSVSAMRVLSTSTDLEAAVADALLLGDARSKKPVRRRYEPYGMYSDDDANSDASSVCSERSYGSRNGGIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRTLSRVELKRLCEIFTRMFADPHSKRVFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMDPTDFVNSSETRLAVSRIITWTTEPKSSDVRKAAQIVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLKNSSNAGVGSPSNTIGRTPSRHPSSRTSPLTSPTNCSHGGLSPSMLDYDTENLNSEEIYSSLRGVTEAIEKFSFRSQEDLNEPIKRDGKKDCDIVSRDGGAASPATEGRGGSEVEGGRMALDNKTSLLNTQPPRAFPGPRAREYNPYPYSDTINTYDKTALKEAVFDDDMEQLRDVPIDHSDLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPARFKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERITKESLLQLLVDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIGEDLKPHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSTHS
Protein: Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) (Q8BN21)
Organism: Mus musculus (Mouse)
Function: Serine/threonine kinase that regulates several signal transduction pathways. Modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes (By similarity). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (By similarity). Phosphorylates histone H3 (By similarity). Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and activity (By similarity). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins (By similarity). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (By similarity). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (By similarity). May also phosphorylate MAPK8IP1 (By similarity). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14645249}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:31142202}; Single-pass type IV membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q86Y07}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:31142202}.
Interaction partners:
- Ankyrin repeat and LEM domain-containing protein 2
- Barrier-to-autointegration factor
- Barrier-to-autointegration factor-like protein
Sequence:
MAPRRKEKYKLPVPLPEGKILDDMEGNRWALGKMIGSGGFGLIYLAFPTNKPNKDARHVIKLEYQENGPLFSELKFYQRAAKRECIQKWIQQRKLDYLGIPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLDQNGGFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDFTNPDRVYLADYGLSYRYCPNGNHKQYQEDPRKGHNGTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEAKLDDPVAVQTAKTNLLDELPESVLKWAPSGSSCSELVKYLMYVHNLAYDDKPDYQKLKKILNPDGVPLGPLEFSTKVQSVHVRTPAQQKVDSPKATRKPANEFPAKFPKKVHRETRARQREEQEDSQPTMLQSRPAAPENSRTRKIHEYSDIFSEMQSLQQTPSYMSFQGSYCKPYLDCTRRDPIRKPRSLPRYRHTPTGNLGVTDLESSPRFWPAIFQLTLSEETKADVYYYGITIFCLLIFVFLALYFL
Protein: Transcriptional regulator PerR (Oxidative stress genes repressor) (Q97FU2)
Organism: Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W)
Function: Represses the expression of most of the genes involved in oxidative stress response, such as rbr3A-rbr3B, dfx, rd, nror, fprA1 and fprA2, coding for reverse rubrerythrins, desulfoferrodoxin, rubredoxin, NADH-rubredoxin oxidoreductase (NROR), and oxygen-reducing flavoproteins, respectively. Thus, by controlling primarily oxygen and reactive oxygen species (ROS) scavenging, PerR plays an important role in the oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. Probably acts as a peroxide sensor.
Interaction partners:
- Desulfoferrodoxin
- Reverse rubrerythrin-1
- Reverse rubrerythrin-2
- Rubredoxin
- Flavo-diiron protein FprA1
Sequence:
MNDISTIFKEKKLKLTPQRIAVYKYLKSTHEHPSAETIYKAIQSDYPTMSLATVYKALKTLAEVHLIQELNVGEGNFRYDANSSSHPHIQCLSCGKVDDIMGITFDNLNKDVSSHTDYDVISNKLYFYGICKDCKDKA
Protein: Chain length determinant protein (Polysaccharide antigen chain regulator) (Q04866)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 20.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- UDP-N-acetyl-D-mannosamine dehydrogenase
Sequence:
MTVDSNTSSGRGNDPEQIDLIELLLQLWRGKMTIIVAVIIAILLAVGYLMIAKEKWTSTAIITQPDAAQVATYTNALNVLYGGNAPKISEVQANFISRFSSAFSALSEVLDNQKEREKLTIEQSVKGQALPLSVSYVSTTAEGAQRRLAEYIQQVDEEVAKELEVDLKDNITLQTKTLQESLETQEVVAQEQKDLRIKQIEEALRYADEAKITQPQIQQTQDVTQDTMFLLGSDALKSMIQNEATRPLVFSPAYYQTKQTLLDIKNLKVTADTVHVYRYVMKPTLPVRRDSPKTAITLVLAVLLGGMIGAGIVLGRNALRSYKPKAL
Protein: Protein NDL1 (Protein N-MYC DOWNREGULATED-LIKE 1) (Q9FJT7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Interacts with the heterotrimeric G protein beta subunit GB1 and plays an significant role in GB1-dependent regulation of lateral root formation. Involved in a signaling pathway that modulates root auxin transport and auxin gradients. Acts partially by positively regulating the auxin carrier PIN2 and AUX1. Acts, together with GB1 as positive regulator of meristem initiation and branching. GB1 and NDL1 positively regulate basipetal inflorescence auxin transport and modulate MAX2 expression in shoots, which regulates organ and lateral meristem formation by the establishment and maintenance of auxin gradients.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19948787}. Note=Localizes in punctate cytoplasmic structures. {ECO:0000269|PubMed:19948787}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta
- Expressed protein
- Acireductone dioxygenase 2-requiring) 2)
- Annexin D1
- Small ribosomal subunit protein eS27y
- Probable plastidic glucose transporter 3
- Acireductone dioxygenase 1-requiring) 1)
- Guanine nucleotide-binding protein subunit gamma 2
- Regulator of G-protein signaling 1
- Guanine nucleotide-binding protein subunit gamma 1
Sequence:
MTDSYGAVSVDVGTIYLGGKEHRVKTASGVVSVIVYGDREKPALITYPDLALNHMSCFQGLFFCPEAASLLLHNFCIYHISPPGHELGAAPICPNDSVPSAENLADQILEVLNFFGLGVVMCMGVTAGAYILTLFAMKHRERVLGLILVSPLCKAPSWSEWFYNKVITNLLYYYGMCGVVKEFLLQRYFSKEVRGNVEIPESDIAQACRRLLDERQGINVLRFLDAIDRRPDISSGLKKLKCRTLIFIGDQSPFYSEAVHMAATLDRGYCALVEVQACGSMVTEEQPHAMLIPMEYFLMGYGLYRPSLFSESPRSPLSPSCISPELLSPESMGLKLKPIKTRISAA
Protein: Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2) (Q99757)
Organism: Homo sapiens (Human)
Function: Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12032145, ECO:0000269|PubMed:12080052}.
Interaction partners:
- Thioredoxin-interacting protein
- Thioredoxin reductase 2, mitochondrial
- Mitogen-activated protein kinase kinase kinase 5
- Thioredoxin
- Thioredoxin-dependent peroxide reductase, mitochondrial
- Thioredoxin reductase 1, cytoplasmic
- Peroxiredoxin-5, mitochondrial
- Peroxiredoxin-1
- 3-mercaptopyruvate sulfurtransferase
- Mitochondrial peptide methionine sulfoxide reductase
Sequence:
MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
Protein: BAG family molecular chaperone regulator 1 (Bcl-2-associated athanogene 1) (Q0WUQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses.
Interaction partners:
- Pyridoxal phosphate
- TraB family protein
- Transport/golgi organization-like protein
- Protein rolling protein
- At2g17710/T17A5.17
- AT5g51950/MSG15_3
- BAG family molecular chaperone regulator 5, mitochondrial
- Glycerophosphodiester phosphodiesterase GDPDL5
- Metacaspase-7
- GDSL esterase/lipase At1g29660
Sequence:
MMKMMRNKPTNLPTAGMTNGGRGSGGGGGGGGRESGGRDLEIRPGGMLVQKRNPDLDPVGPPPPPMIRVRIKYGAVYHEINISPQASFGELKKMLTGPTGIHHQDQKLMYKDKERDSKAFLDVSGVKDKSKMVLIEDPLSQEKRFLEMRKIAKTEKASKAISDISLEVDRLGGRVSAFEMVTKKGGKIAEKDLVTVIELLMNELIKLDAIVAEGDVKLQRKMQVKRVQNYVETLDALKVKNSMANGQQKQSSTAQRLAPIQEHNNEERQEQKPIQSLMDMPIQYKEKKQEIEEEPRNSGEGPFVLDSSAKWETFDHHPVTPLSSTTAKNNAIPPRFNWEFFD
Protein: Male-enhanced antigen 1 (MEA-1) (Q16626)
Organism: Homo sapiens (Human)
Function: May play an important role in spermatogenesis and/or testis development.
Interaction partners:
- Kelch domain-containing protein 3
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
- Golgin subfamily A member 3
- Spermatogenesis-associated protein 16
- Protein BRICK1
- Kelch-like protein 1
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- Zinc finger Y-chromosomal protein
Sequence:
MGPERHLSGAPARMATVVLGGDTMGPERIFPNQTEELGHQGPSEGTGDWSSEEPEEEQEETGSGPAGYSYQPLNQDPEQEEVELAPVGDGDVVADIQDRIQALGLHLPDPPLESEDEDEEGATALNNHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWAREISDAQWEDVVQKALQARQASPAWK
Protein: Protein FAM210A (Q8BGY7)
Organism: Mus musculus (Mouse)
Function: May play a role in the structure and strength of both muscle and bone.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:29618611}. Cytoplasm {ECO:0000269|PubMed:29618611}.
Interaction partners:
- Elongation factor G, mitochondrial
Sequence:
MQWNVPRTMSRLALRTFVEAQKARLFDHHWRIKGPLLVHRGEYRVAWTPHLRKQWLHLSAVQCLAKQRNLLDAQPPQLGTLRQERWEQDILSKRVLSSSSTSQETPSEKKEETDPLQDKSISLYQRFKKTFRQYGKVLIPVHLITSGIWFGTFYYATIKGVNVIPFLEVIGLPDSIVDILKNSQSGNALTAYAMFKIATPARYTVTLGGTSFTVKYLRSHGYMSTPPPVKEYLQGRMEETKELITEKMEETKDRLTEKLQETKGKVSFKKKVE
Protein: Homeobox protein Hox-A13a (Q6W990)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MTTSLLLRPRWIDPVMFLYDNGGGLDDTSKNMEGFTGGNFSPSPCRNLMSHPASLAPSATYPSSEVAAAAAGDSGKQCSPCSAVQGSASASISYGYFGGGGYYPCRMSHHHGSGGGVKTCAQSPASGSPYGEKYMDTSASTGEDYTSSRAKEFALYSSYASSPYQPVPSYLDVPVVQAISGPSEPRHESLLPMESYQPWAITTSGWNGQVYCTKEQQQTGNVWKSSIPESVSHGGADGSSFRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISAQTNLSERQVTIWFQNRRVKEKKVVNKLKSSS
Protein: ATP-dependent DNA helicase PIF3 (EC 3.6.4.12) (DNA repair and recombination helicase PIF3) (Q383A1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of genome stability.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19646907}.
Interaction partners:
- DNA 3'-5' helicase
- TFIIH basal transcription factor complex helicase/translocase XPB subunit
- Helicase, putative
Sequence:
MRLAAESSLVFFVSHFYFERFFSFVMVAYTLDTLFASDIDSATLFYSEGCGPIRLVALSAQMRRLVRLGPIRVAKACVEVRPMAPTKEFFEEGRQLQHIEAAGVGDFPDSERSGDTFVNPFTGRLTPTWGRVAKELFSLGFEHSIVNPFRLVWNPTKAALVSDAALQPFRTSTVTWRRNLAALLSRRDAADAVGEEIHRLYNEITSAYLPPKLDTMHDPRLSTMTMTPDQQNVIRCALRGYSMFIGGSAGTGKTVLLKAIHRKLTEMGLRVAMTATTGVASVQLGGCTFHLAFGVPIKGEEGTRKRWDSNAFRAVDVVIIDEVSLLDAELFETFEEEARMARLQQSPFGGLQVIACGDFLQLAMMDVSIGGPCYQSHAFRHLIPVCLVTSMRQAQGDPFCELLGQLRVGKFDKKAFKALDRPVSGDANNVTYIFPRRCDAQRLNDEKLCELRSEEMIFAPQRGPLQLVGNFTPAGLVDWGRKKDFPKREKIITVLSEEIKRITGVDIVDHNIVVMPAGGEKNAVLIRLRHSEDRNVLICKNGGSKEHGASNEGGAEESHWRAILEATAGRLKGKLHQIYNQDPHNFIPPSVSLMLADASLHPNAELISPLRLKLGCRVMINRNLSRTVSNGSVGIVEAFAAPNLDLFPRRHETSPKAFHTWSLERNGFQRLPIVRLLSGEVVQLPPLSVMIGGTPSTYFYGHELFVLPLQLGYGFTVHKVQGLTLEGTVVLDCKKFFECPHLVYVACSRVRSMDQLIVRNVRSDMIIVRQSALDFTNALRDASVMSSLDPPDGCTRASWVRRLSPLLVGLTD
Protein: Iron-sulfur assembly protein IscA, chloroplastic (Plastid SufA-like protein) (Protein scaffold protein AtCpIscA) (Q9XIK3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the assembly of chloroplastic iron-sulfur proteins. Is able to transfer iron-sulfur clusters to apo-ferredoxin.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:15888686}.
Interaction partners:
- Monothiol glutaredoxin-S14, chloroplastic
- Iron-sulfur cluster assembly protein 1
- NifU-like protein 2, chloroplastic
- Bifunctional monothiol glutaredoxin-S16, chloroplastic
- NifU-like protein 4, mitochondrial
- NifU-like protein 5, mitochondrial
- NifU-like protein 3, chloroplastic
- Cysteine desulfurase 1, chloroplastic
- Iron-sulfur cluster co-chaperone protein HscB homolog
- Uncharacterized protein At5g03900
Sequence:
MAFATGITTSSNPTFLGLKISNTSLRSVVSCNSISFPSLSYVNLNLNRRNRLSVRSASVPAAPAMEGLKPAISLSENALKHLSKMRSERGEDLCLRIGVKQGGCSGMSYTMDFENRANARPDDSTIEYQGFTIVCDPKSMLFLFGMQLDYSDALIGGGFSFSNPNATQTCGCGKSFAAEM
Protein: UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase) (Q9W0P5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Interaction partners:
- GH11113p
- Probable galactose-1-phosphate uridylyltransferase
- UDP-glucose 6-dehydrogenase
- UTP--glucose-1-phosphate uridylyltransferase
- Aldose 1-epimerase
- mannose-6-phosphate isomerase
- GDP-mannose 4,6 dehydratase
- Glucose-6-phosphate isomerase
- N-acetyl-D-glucosamine kinase
- Aldose 1-epimerase
Sequence:
MAPPTVLVTGGAGYIGSHTVLEMLNAGYNVICVDNLCNAYSSGAKLPEALSRVQEITGKKVNFYRVDITDREQVRSVFQEHKIDMVAHFAALKAVGESCRIPLQYYHNNMTGTNVLLEAMADNNVFKFVYSSSATVYGEPKFLPVTEEHPTGNCTSPYGKTKYFTEEILKDLCKSDKRWAVVSLRYFNPVGAHISGRIGEDPNGEPNNLMPYIAQVAVGRRPSLSVYGSDFPTHDGTGVRDYIHIVDLAEGHVKALDKLRNIAETGFFAYNLGTGVGYSVLDMVKAFEKASGKKVNYTLVDRRSGDVATCYADATLADKKLGWKAERGIDKMCEDTWRWQSQNPNGYANK
Protein: Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF) (Q03386)
Organism: Rattus norvegicus (Rat)
Function: Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q03385}. Nucleus {ECO:0000250|UniProtKB:Q03385}. Note=Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. {ECO:0000250|UniProtKB:Q03385}.
Interaction partners:
- Ras-related protein Ral-A
- Ras-related protein Ral-B
- Ras-related protein R-Ras
- GTPase HRas
- GTPase NRas
- Ras-related protein Rap-1A
- Ras-related protein Rap-1b
- Ras-related protein M-Ras
- Transforming protein RhoA
- RAS related 2
Sequence:
MVQRMWAEASGPIGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCPVVLHSFTQLDPDLPRLESSTQEIGEELINGVIYSISLRKVQLYPGATKGQRWLGCENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENGLCAKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRAKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKASDRARVVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRTQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIVPEEHFGAWFRAMGRLSEAESYNLSCELEPPSESASNTLRSKKSTAIVKRWERRQAPSTELSTSSSAHSKSCDQLRCSPYLSSGDITDALSVHSAGSSTSDVEEINMSFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYDFILKKRAFTKGAKVKHGASSTLPRMKQKGLRIARGIF
Protein: XPG (Q4U2Q3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGVTGLWKLIEPCGKPVPVETLEGKILAVDISIWLHQVVKGFQDNKGSALSNAHLLGLFHRLCKLLYYRVRPVFIFDGCVPQLKRDTIARRQQQRNKLSNEADRIQALLLQSLAKEKVVQQALGKNAELLLKSPVKRPPPAKKNDEDDLFKLPELPAASVQNNQDESEQDTSASASDSSFDESTARHSYNSSLQAIDVKSQHFRNLPADVRHEILTDIKETRKQSSWGRLHELPARSDDFCSFQMKRLLKRRAVQESLEQAEQEMGGHTLTYAELCDFFNEEGILTPTAIEQCTRQISSDEHTRFLLVRDLKKKAMESTKQEVKMEMIEEVPAEEEDEKPSTSTKKEAVKSVDLGTEFDEDLAKALSMSMEETKVYDEKDYEYDSDQELRLNRAQTKQLRHAAKGPARAYMIEYGGMNDEEVGNIMETTQFNDTQSLEKLLEITTVPTDMADNSIEEAKLISQAIEESKQLSQAIEESKKNLNEDKVEIVDTDTDSDLEEVMEVQELDKGKKNLEICVDITGQADSNDLFADIFEDGEANKIEKTISVEEDDDFIEVKDSEELKLDTEDENKPITNKSIKESNEVKPFIDEIIEVKDSQEAVPAEPNLKPDLESILNDLKKQTAAVKDIQLNVNEEEKPKPKVEISSILDELKVKMADVKNITLDNVKLSNSVPIILSSDDESTLKSSKIVPKQELIELCDSDDNKNNRLSPNKTPSKNKSIKDFFETSYVVKRTPDKSQASNETSPGTPKTPKPFFRKRTPKSGRKRASDANEDSDEEVSPTKRSSKASKSLFEPKEPEEEKTVDPEEIIKDAAEALKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVAPMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFRAEQIEQTFNCNRGKLIQLACLVGSDYTTGIHGIGAVTALEILASFSGRDANGPGICNQSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYLAPTIDDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAKSALRVQQPHVSKRVQLAIDKMSGKIDETPEKPKKVTRTRRAKAAPPTDDDLAIADVATKAARPKRGKRKAAPESVVLDGELPSTSQSIPKPEKCPRIPSSVEVIPQREKDLEQMRLNKAKAAEILKNSAKANRK
Protein: Chemotaxis protein (Q0PBM3)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Interaction partners:
- histidine kinase
- Chemotaxis protein
- Methyl-accepting chemotaxis signal transduction protein
- protein-glutamate methylesterase
- MCP-type signal transduction protein
- Methyl-accepting chemotaxis signal transduction protein
- Chemotaxis protein methyltransferase
- Methyl-accepting chemotaxis signal transduction protein
- Bipartate energy taxis response protein cetA
- MCP-type signal transduction protein
Sequence:
MSNEKLEQILQKQQTQMAGPDVDQREDDIIQLVGFVVGDEEYAIPILNIQEIIKPIEYTRVPSVPDYVLGVFNMRGNVMPLIDLAQRFHLGSSKMTPQTRYIVLRGETNGTGVGGNAGFVIDRLTEAIKIHRNRIDPPPETLVKDKGMIYGIGKRDENILTILKVEALLKREF
Protein: MIP14774p (Rab35, isoform C) (F0JAF7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPNGLTCVGKSSLLIRFSDDTFSGSYITTIGVDFKIRTVDIEGMRVKLQIWDTAGQERFRTITSTYYRGTHGVIVVYDVTNGESFANVRRWLEEIQNNCDVVKKVLVGNKNDDPDRKVVITEDAQRFAKQMDIELFETSAKDNINVENMFLSITRQVLDHKLRTSPNEQQKDTLHLKPNPKGSKGGKCCR