wanglab/gogpt-training-data huggingface dataset:
Protein: Apoptosis regulator Bcl-2 (Q00709)
Organism: Gallus gallus (Chicken)
Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P10415}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:P10415}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P10415}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P10417}.
Interaction partners:
- Beclin-1
- BCL2 like 11.
- BCL2 interacting protein 3.
- BH3-interacting domain death agonist
- Caspase-3
- Bcl-2 homologous antagonist/killer
- Caspase 9
- Cytochrome c
- Uncharacterized protein.
- Apoptotic protease-activating factor 1
Sequence:
MAHPGRRGYDNREIVLKYIHYKLSQRGYDWAAGEDRPPVPPAPAPAAAPAAVAAAGASSHHRPEPPGSAAASEVPPAEGLRPAPPGVHLALRQAGDEFSRRYQRDFAQMSGQLHLTPFTAHGRFVAVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIATWMTEYLNRHLHNWIQDNGGWDAFVELYGNSMRPLFDFSWISLKTILSLVLVGACITLGAYLGHK
Protein: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32) (Q7L7V1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000269|PubMed:16959245}. Mitochondrion {ECO:0000269|PubMed:16959245}.
Interaction partners:
- BRCA2 and CDKN1A-interacting protein
- Something about silencing protein 10
- Activator of basal transcription 1
- Uroporphyrinogen-III synthase
- Bystin
- 116 kDa U5 small nuclear ribonucleoprotein component
- Tuftelin-interacting protein 11
- U4/U6.U5 tri-snRNP-associated protein 1
- NudC domain-containing protein 1
- Cell division cycle 5-like protein
Sequence:
MEEEGLECPNSSSEKRYFPESLDSSDGDEEEVLACEDLELNPFDGLPYSSRYYKLLKEREDLPIWKEKYSFMENLLQNQIVIVSGDAKCGKSAQVPQWCAEYCLSIHYQHGGVICTQVHKQTVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNVPVIEVKNKHPVEVVYLSEAQKDSFESILRLIFEIHHSGEKGDIVVFLACEQDIEKVCETVYQGSNLNPDLGELVVVPLYPKEKCSLFKPLDETEKRCQVYQRRVVLTTSSGEFLIWSNSVRFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEEFASKDMTPLKPAEMQEANLTSMVLFMKRIDIAGLGHCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFSHVPHGAEEAALTCWKTFLHPEGDHFTLISIYKAYQDTTLNSSSEYCVEKWCRDYFLNCSALRMADVIRAELLEIIKRIELPYAEPAFGSKENTLNIKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGYSITKKMPEWVLFHKFSISENNYIRITSEISPELFMQLVPQYYFSNLPPSESKDILQQVVDHLSPVSTMNKEQQMCETCPETEQRCTLQ
Protein: GM09977p (Q9VSC5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Transitional endoplasmic reticulum ATPase TER94
- UBX domain-containing protein 7
- Caspar, isoform A
- UBX domain-containing protein 6
- GH01724p
- Uncharacterized protein
- Large proline-rich protein BAG6
- Derlin-1
- UBX domain-containing protein 4
- BTB/POZ domain-containing protein 9
Sequence:
MSEVQTLMDMGFPRERVEYALEVTSNKGVEPAMEWLLAHVDDPIPSRQGAGESPGSTAQPAAAVDSSAAAASSSTSGAGETSAPVAKSLKCDECGKVLRDHTEVEYHAAKTGHTKFSESEEEKKALTEEEKKAQLALIEEKLKQKRIEREEREKIEALQREKNRIKSGKDMTEAKRRMEELEMKKIVEQRKREKDEEKAARDRVKAQIEADKAARKAREQKELGNAEPAPSVSSTTVSSPPAGVKSPPRDYTETRIQVRLQDGSTLQETFNVKEQLSAVRVFIQMKTGIESPFSLMTTFPRKLFAEDDYEKPLEVLGLVPSAVITMTKTPA
Protein: Secreted protein (Q8VKS4)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MESAESIQRLTEFEMKLKFARLSTAILGCAAALVFPASVASADPPDPHQPDMTKGYCPGGRWGFGDLAVCDGEKYPDGSFWHQWMQTWFTGPQFYFDCVSGGEPLPGPPPPGGCGGAIPSEQPNAP
Protein: Fl(2)d-associated complex component (Protein Xiong) (Q9VWN4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the WMM complex, acts as a key regulator of m6A methylation by bridging fl(2)d to the RNA-binding component nito. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy.
Subcellular location: Nucleus {ECO:0000269|PubMed:29535189, ECO:0000269|PubMed:29555755}.
Interaction partners:
- Protein virilizer
- Pre-mRNA-splicing regulator female-lethal
- N
- RNA-binding protein spenito
- E3 ubiquitin-protein ligase Hakai
- N
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 1
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB2
Sequence:
MEKKAKESLRRYKKAARHSATHSSSSDSTSDSDSGSSSYSSTDSEQGVGGVGVGVGVPGGAGGPGGSGSVHGHPHTHGHGHHPRSAERHHRKKKSSRRGGSSSGDEPSSSRRKRDKRDHVQKKLVAKRNHIKRKLKEARLKKRAAAALSGHVHRSLSPTTRAKLKKLAERKRLRAASKEQRERDKLRVVQRDRERDHHRLGSSRSPPSSSTTTTTKIRIHQDIVGKRQKSPGLGSGLGGGSSSSSSRMHHQLMSREKIIIQTRARGRTPSLERERERERERERERERERHDLSLRERDRRDRERERAEREAARDKERAEALARCQERQRERERLAREKLRRQEEEEGGKRGGPGRDLDLPPYGSRERSLDTVERERERERSGRHVRDKRELDPYEREQEYLEERHGHGLIDEMRRYRRRDLSPMPEHYAPRLRDPRELYSEEERERAYKRAYLDARYSSREREAWLEARELRERELQGREYRDLETEDTLYPDERERLIRDRERDRERERDRERERNIGPRGDFRPEWEREWEEEGAGGGPGGPSGTPGRPGGFVGGPKRGKPPAHAGGGPPSQQQHHSASEPDWDADERERERERERDRERERDREDRPDTGGGGAGGDRPSIKNEPAWLEHDQREKPRGWQQQSSNSGGDWRDNDDAPPAPSHPHPASPHHHVHPRGERGSGRGFRRGGHGHGDHGERPGYRSHPPPLMTLPVQPPGGYSRGFPHKRLPYGSGRDGAALGARDGGLPGSSTFLKKHTHAPLVSPTQTPLLNPLLNAAKPNAAAQASAVAAATTAVAAAKAAAQSAANATTNPGILAQVSKLNTVCIKQEDASEDSAGTPELGAQDSPTQSLNLNQSLSSEGNPVKQELIRTSAVEGELSEISDSDDDILNKTDKVRPKNELPTETEQEMDTNADEVKSEALHIVAGHPIKGEEGDEVLDFEEISDGELEEDARHKGIGDALGVDWQGLIAETRQQASDAQAAQQGVDRGTSAKQRWQPYRVLLDLGISFGMAGEGYARCVMEEARQQLLQEKEQGQQRELDGDEEPPAKIPSPLLDYREFLASQQQLEPLACVQMGLRSAAVERQRLVGNVCGPGSRALSARQDLRLRRQLCGLPARECEFPRSVPIVGEGLRNLAMQMFQRRLLDVK
Protein: PRA1 family protein (Q9VJ59)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363107}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363107}.
Interaction partners:
Sequence:
MTTPSTSVGDAAAALSGNLQLPPLRTLDDFILGSARFQLPNLKDFEKWGNRVVKNLLYYQTNYFLLFITIYVLMIFFNPSKIITGLLVQALIIGVIWQFFSGKSKKNFIASRLTGGNANAAEQNAQQKWYILAGALLGGYLLLHLLSAVLLTIFTVLLPISLTFIHASLRLRNIKNKLTNSIESFAPSTPMGSLLDALNVRAEGVFN
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q7ZUS7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Immunoglobulin
- Protein phosphatase 6, regulatory subunit 3
- Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
- Ankyrin repeat domain 28b
- Protein phosphatase 6, regulatory subunit 2b
- Protein phosphatase 6, regulatory subunit 2a
- Serine/threonine-protein phosphatase 2A activator
- TIP41-like protein
- Protein phosphatase 2, regulatory subunit A, beta a
- Serine/threonine kinase 19
Sequence:
MAPLDLDKYVEIARQCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL
Protein: TSET complex member tstF (Protein TTRAY2) (Q54K14)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MSSTSNENISSYVIFKSKGQHINTSYNPIDIHPIHPWIVYADSDSNIVIQNYQNNEKILNFSISQHDEEKKEQILLLQKKVPTLSALSSSASGINGTNNNNSGSNSSNNNNNNNGSLSNSPNNNNNVAFIGSTGGVDSRSASVTSIGSGGGVVTPINVNSNSNSNSPSVPTLHVIGNQTLHNRSPNNTIKLSPNSSNNDSLNNNNNNINNNSTNSNNYLNENLDKMKLGQIKFIYFYDKHTRSCKDKKPKISQNKLQNISKAQPSVGIEDYIVVVAENRIVFINYHSQRLREVKIPAFENKSPNSVEFFSNSPFVAFGGPDSMIRLWNTEKWEIEKQLAGHPKGTIVKLKAIEIEGEFLVSGGTDGFVCVWNVKTGSLATQFSKVHEIVDLSYDYVTGQVMALTQDRHIMIYDLNTLKEVSKVSCGKKEFFSIEAYYHSRFNQDLLLGMKQPAQVSFFSRSGSTKEYSIDLDALLNPSKKEKSKLYKVVQHPLQPHLLLCWLNKSVYIVSTLATSIPMQVTTFNSLSNDHTVYYPFAGYLYSSSLTNVLTCEKVQTPIQLSLNENYKLDISPSGKYLSIHAISSGNYQILEISTWKILEKGQALDVAWSGKGKDSTVDEKFGKLEKILESVDSVKKKKTLGILPSIVKSTKKEETVISKILLKTKEFNNNNVVQELLLHANEDRISGGLMLGVYHKESTNSNGTLNYGSGGSIGSGSGSGTISSGSSNLINGSVGGSSSNNSANSNNSNNNNNNNNNNSNNSNNNNNSSQPILEPPIITTGEETESKSFQLLDWWTLQPVGESLPPPLKIYWDQNQTHCAIAFTHYFFVFKLRPTFHMLCRWSLGITSAVWHNNTLFFSTHNDIQCIFPHKHESSPIILASSTGNVFPEDLYDLSSGSLSTSKPNQSFSTLPNIKPTGPISLIEVNNEGLVLLDSNYKFYCIPLTHYLLKFFILAQMEAIDLAMKCSTMVDPKYHYLMAKFLTVRGHPKECLQMNGISNFLKLQICLNNEAFETSLDIVPLITEAIKSGQSITNENNNDEEVTLSSMGKMCIEIGQRAQNKNEYPTAEKAFKLATSLEPNSAYQELALHYVFLKKMNELKELQQSISTTYPLESNLISLFLD
Protein: Huntingtin associated protein 1 (H7C295)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
ADIMRGEDFTPAEEFVPQEELGAAKKVPAEEGVMEEAELVSEETEGWEEVELELDEATRMNVVTSALEASGLGPSHLDMNYVLQQLANWQDAHYRRQLRWKMLQKEPQPRT
Protein: F-box family protein-like protein (F4JUM4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MENKHNPTSHTSHTWSELPELNPCVPLGTLLPDKSCPKTHPLADLIPPRQQQQFMHGNSWKLAPYGRSMIMRYAMQVRGQLAPTVLGINRTWKGDTCWNQIPKTSDCFHMVYKDHKLYFLNKTGSFKIFDFCGDIPQQTFEWSVKVERSQFGPPPPSNPWKVLATKLVVTVTGKVLKVEEMGGARPRTWSFRVFESMLLDQGITVLANDTGGFIRNTIYFSASHGNNTHDIYIFNLETQKTEPLHTLDSYSSSVQFYGAQWFVPSFKH
Protein: Elongase (K0H6Z1)
Organism: Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Uncharacterized protein
- Enoyl-CoA reductase
- 3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein
- Very-long-chain
- Very-long-chain
- Very-long-chain 3-oxoacyl-CoA synthase
- Delta
- Cytochrome b5 heme-binding domain-containing protein
- Cytochrome b5 heme-binding domain-containing protein
- Cytochrome b5 heme-binding domain-containing protein
Sequence:
MAAFSEPVDWLADNAARDVGWQMVHVGDKAHNLTLNPATSSFAVALESTSLWSISTLDYAVHRFLKDFVELDMRKPSTITAGLPLVSSPTPVVLAIFAYIVVVWLWSSYIRRVGLKPRSQDPGWLRALVVVHNWFLCCLSFYMGCGIISEARHHGYSFFGNSGNDGEVKMGFYIYIFYVSKLYEFMDTIVMLLRMNLRQITFLHVYHHASISFVWWIISYVCPYGPAYFSAALNSWIHVFMYLYYLLAATIAKDEERRRKYLFWGKYLTMFQMLQFVSFIGQAVHGLVNPSTYPKNMPRMLFLYSLSLLILFCNFFVAKYMKSSPKLQSKPFKTE
Protein: E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23) (Q8BGX0)
Organism: Mus musculus (Mouse)
Function: Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P36406}. Endomembrane system {ECO:0000250|UniProtKB:P36406}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P36406}. Lysosome membrane {ECO:0000250|UniProtKB:P36406}. Note=Membrane-associated with the Golgi complex and lysosomal structures. {ECO:0000250|UniProtKB:P36406}.
Interaction partners:
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- Thioredoxin domain-containing protein 3
- TNF receptor-associated factor 3
- Intersectin-2
Sequence:
MAALAVNKPGAGVDSGRQGSRGTAVVKVLECGVCEDVFSLQGDKVPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTDLGDSGVWGLKKNFALLELLERLQNGHIGQYGAAEEAIGTSGESIIRCDEDEAHVASVYCTVCATHLCSDCSQVTHSTKTLAKHRRVPLADKPHEKTMCCQHQVHAIEFVCLEEGCQTSPLMCCVCKEYGKHQGHKHSVLEPEANQIRASILDMAHCIRTFTEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHTEHVPGTAENARSCVRAYFSDLHETLCRQEEMALSVVDAHVREKLIWLRQQQEDMTILLSQVSTACLHCEKTLQQDDCRVVLAKQEITRLLETLQKQQQQFTEVADHIQLDASIPVTFTKDNRVHIGPKMEIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNVETVEYKNLKFTIWDVGGKHKLRPLWKHYYLNTQAVVFVVDSSHRDRISEAHSELAKLLTEKELRDALLLIFANKQDVAGALSVEEITELLSLHKLCCGRSWYIQGCDARSGMGLYEGLDWLSRQLVAAGVLDVA
Protein: Rhamnose binding lectin STL1 (Q9IB53)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MLLGQSILFAALQASLFLVPGYGMSEIQRRFLTCGDPSLQCDHGVIMVYGVQFSTIEKLSSNERPKACSDTEAFNGVSNRCDGNEKCDVATSGSVCDLCSTAYLTNIFLDVTYGCLESKKVTTCHGVVHLECGDGVVFLQKALYGRIDSQTCSQGRPQSELTNTKCSQEGTLALWSQRCDGKQTCEVNMRVNQISDPCVGTYKYLDVPYICLPAKTSITCEGSTSSLDCGKGVIKVFHANYGRRDGSTCSAGRHELSNQNCLQPKTLDVVKQWCEGKSQCTVGLDPVFGDPCYGTYKYLEVSYTCLGGSPTV
Protein: Cytochrome b561 homolog 2 (P75925)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein YceI
Sequence:
MSFTNTPERYGVISAAFHWLSAIIVYGMFALGLWMVTLSYYDGWYHKAPELHKSIGILLMMGLVIRVLWRVISPPPGPLPSYSPMTRLAARAGHLALYLLLFAIGISGYLISTADGKPISVFGWFDVPATLADAGAQADFAGALHFWLAWSVVVLSVMHGFMALKHHFIDKDDTLKRMLGKSSSDYGV
Protein: N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (AGA) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] (Q64191)
Organism: Mus musculus (Mouse)
Function: Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
Subcellular location: Lysosome.
Interaction partners:
Sequence:
MERKSNLSLLLLLLVLGMPLVRGSSPLPLVVNTWPFKNATEAAWWTLLSGGSALDAVENGCAVCEKEQCDGTVGFGGSPDEGGETTLDAMIMDGTAMDVGAVGGLRRIKNAIGVARRVLEHTTHTLLVGDSATKFAESMGFTNEDLSTKTSRDLHSDWLSRNCQPNYWRNVIPDPSKYCGPYKPSGFLKQSISPHKEEVDIHSHDTIGMVVIHKTGHTAAGTSTNGIKFKIPGRVGDSPIPGAGAYADDTAGAAAATGDGDTLLRFLPSYQAVEYMRGGDDPAIACQKVILRIQKYYPNFFGAVICASVNGSYGAACNKLPTFTQFSFMVSNSLHNEPTEKKVDCI
Protein: Protein CWC15 homolog (Q9V3B6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in pre-mRNA splicing.
Interaction partners:
- Pleiotropic regulator 1
- Cell division cycle 5, isoform A
- Pre-mRNA-processing factor 19
- Protein BUD31 homolog
- Puff-specific protein Bx42
- LD41978p
- 116 kDa U5 small nuclear ribonucleoprotein component
- Pre-mRNA-splicing factor SPF27
- Protein crooked neck
- Pre-mRNA-processing-splicing factor 8
Sequence:
MTTAARPTFDPARGGSGRGEKDLSALSKQYSSRDLPGHTKLKYRETGQGTSDENRNRDFRKELEEREREARSGTGATSSSSGKALPSIVRKAIEANNAGGGSSAAKRSKPDAGQQQAQQAAQQQAANMDADEPLDNDSSDSDSDSDDDDAALLAELQKIKQERLQETARRESEKKQEDERIRMENILSGNPLMNYEPGTAASAAGRASGLGGDLKIKRRWDDDVVFKNCARSAPDKKTHFVNDALRSDFHKKFMDKYIK
Protein: CCAAT/enhancer-binding protein homolog 1 (Q18909)
Organism: Caenorhabditis elegans
Function: Transcription factor (By similarity). Binds to promoter regions of target genes, perhaps at the motif 5'-[AGCT]TT[AGT][TC]GAAA[ACT]-3'. Modulates expression of genes involved in development and in stress responses, including those regulating the p38/MAPK signaling pathways such as MAPKK sek-1 and phosphatase vhp-1. Involved in innate immunity. Plays a role in repressing the response to infection by the Gram-negative bacterium P.aeruginosa, perhaps acting independently of the pmk-1 or pmk-3 p38/MAPK pathways. However, also plays a protective role in the response to infection by P.aeruginosa. Required in axonal regrowth following injury and synaptogenesis. Following axon injury, in concert with transcription factor ets-4, activates expression of receptor tyrosine kinase svh-2. May function downstream of the Ca2+-activated p38/MAPK pathway to promote axon regeneration. Plays a role in modulating polymerization of neuronal microtubules. Involved in modulating lipid homeostasis.
Subcellular location: Synapse {ECO:0000269|PubMed:19737525}. Cytoplasm {ECO:0000269|PubMed:19737525}. Nucleus {ECO:0000269|PubMed:19737525, ECO:0000269|PubMed:31417366}. Cell projection, axon {ECO:0000269|PubMed:19737525}. Note=Localization to nucleus dependent partially upon importin ima-3. {ECO:0000269|PubMed:31417366}.
Interaction partners:
- MAP kinase-activated protein kinase mak-2
- Transcription factor ets-4
- cAMP-dependent protein kinase catalytic subunit
- Mitogen-activated protein kinase kinase kinase dlk-1
- Mitogen-activated protein kinase pmk-3
- E3 ubiquitin-protein ligase rpm-1
- Tyrosine-protein kinase receptor svh-2
- Transcription factor atf-7
- Cytochrome c oxidase subunit 5A, mitochondrial
- COX5B-domain-containing protein
Sequence:
MYSKLNYSHQKGDQALKHPHLVRLQQSEVRGFTDMPNNGASTSSAGSFARQDSLTIAASLQQRDRERHPVDFMETELDLGDYLQVLHDLDVPTDNVDFDDAELQKCNILYDGEHPYEQPELNGYERHVAYGTGYRVPGDYDQDGYKMNCEVKAETPDFGATKTRRAVKRPVPYDDYQKEYSEESSDMTDNDGSVDDSYFEPKSKKTKSAGLENFKPQTRARKYKLKADEEKAEPTYKLKRARNNDAVRKSRKKAKELQDKKEAEHDKMKRRIAELEGLLQSERDARRRDQDTLEQLLRNKGPMKEQRMPQRHILENFNK
Protein: F-box/kelch-repeat protein At5g42350 (Q9FII2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RNI-like superfamily protein
- F-box/kelch-repeat protein At5g48980
- F-box protein At4g02760
- Disease resistance protein
- F-box/FBD/LRR-repeat protein At5g44980
- Disease resistance protein
- F-box/kelch-repeat protein SKIP25
- FAD/NAD
- UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase
- UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase 1
Sequence:
MMISEKPLGVEESIRQDLEVLTVSRRLVKSVSQKLKKKIHKTEVVEDEEIARGAVNCLSISVGCRVADTGEDFEDSSNKRWSSASEEGKGLMTICGTEETRLDCFSYGVRERFWKKNNRKYLADSGQDYRKHVYLPDDILEMCLMRLPLTSLLNAHLVCKKWQSMANTQRFLQMRREGSFQTPWLFLFAALKDGCSSGDIHGYDVSQDKWHRIETDLLKGRFMYSVTSIHEEIYIVGGRSMDRNSFKSHRGILVFSPSIKAWRKIASMRHARSLPIVGATEVTSEFSTMQTKQNRQDRRFHLSRVGGESDVYEDPHRLSVRRQNRNSADQNGTKSHRLIRQKLDRLNRNSSKRFVLIAIGGTGLFDEPLDSGEIYDSATNTWSEMQRLPMGFGVVSCGIICNGIFYAYSENDKLSGYDIERGFWITIQTSPIPPRVHEFYPKLVSCNHRLFMLSVSWCDEGDGQIGRRNKAVRKLWELDLVYLTWTEVSVHPDAPMDWNATYVSDQNILMGIEMFKIFGQVLSFFTVCDVLTEEASWRHVSRNQRSQKLNLSCTNKTIALLHL
Protein: Rap guanine nucleotide exchange factor 6 (A0A5F9ZHG7)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MPLDFLPLCSALVHSDIFMYYRFINCPHVVLGQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV
Protein: Probable non-specific lipid-transfer protein 3 (TaLTP3) (Q84N29)
Organism: Triticum aestivum (Wheat)
Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).
Interaction partners:
Sequence:
MARLNSKAVAAAVVLAAVVLMMAGREASAALSCGQVDSKLAPCVAYVTGRASSISKECCSGVQGLNGLARSSPDRKIACRCLKSLATSIKSINMGKVSGVPGKCGVSVPFPISMSTNCNNVN
Protein: B30.2/SPRY domain-containing protein (Q9XXH4)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MRSSKGGRGRQAAPKTAPTTVCYCDGKRELGSVEVVCSTCLKWFHGRCLKEFHEFSRNSNGVPFMICYTFTCKQCRPTAEDWKAKKADLVQMCVTVLATLSAERLKADGKLSAEHVPEDFTYLSLKDEIVPYMNENWYMLTAIKQKKEWHQNLAPTLLKEKNIFVQHNDDDDLFALAEKNLSLLGPLHEAVKLIGKRPIERENREPRHIELPPIEGPKTRGASKRRHAEAPVTGKKQKLAADYSSTAAPNGVQIDIPFSKDNYRYYLTEVDPNVPEDPAWNQNQSSAYVIPSFHYRELLNPTVNVSSNDRAFQLSINGNSITGFEGYSMARASHGVSKGTWYFEVNFDDQPDDSHIRIGWSQSYASLQACVGYNKFSYGWRSKHGTKFHEAKGKKYHFGGFKQGDVLGCLIHLPVDKKLQIPANLPSEKYLPVSHKGFNLISFKANYFFEVQEESADIAKTLVEMPGSYIEFFHNGKSCGKAYENIYAGAYYPSISIFKSATATMNLGPKFRNLPRGATGIHARADEQQHEQTLSDMLYLVSKEVNLDHPPRVKREDDDDVKDIKKEIKQEI
Protein: Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) (P63098)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q63810}. Cell membrane {ECO:0000250|UniProtKB:Q63810}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q63810}. Cell membrane {ECO:0000269|PubMed:25255805}; Lipid-anchor {ECO:0000269|PubMed:25255805}. Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy. {ECO:0000250|UniProtKB:Q63810}.
Interaction partners:
- Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
- Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
- Protein phosphatase 3 catalytic subunit alpha
- Nuclear factor of activated T-cells, cytoplasmic 1
- Peptidyl-prolyl cis-trans isomerase FKBP1A
- Nuclear factor of activated T-cells, cytoplasmic 3
- Peptidyl-prolyl cis-trans isomerase A
- Nuclear factor of activated T-cells, cytoplasmic 4
- Calmodulin-like protein 4
- Calmodulin-1
Sequence:
MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
Protein: E3 ubiquitin-protein ligase APD4 (EC 2.3.2.27) (Protein ABERRANT POLLEN DEVELOPMENT 4) (F4ISV9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in pollen mitosis II (PMII) regulation during male gametogenesis.
Subcellular location: Endomembrane system {ECO:0000250|UniProtKB:Q0WS06}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:Q0WS06}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable protein phosphatase 2C 79
- Probable protein phosphatase 2C 63
- Probable protein phosphatase 2C 68
- Probable protein phosphatase 2C 64
- Probable protein phosphatase 2C 46
- Probable protein phosphatase 2C 42
- Probable protein phosphatase 2C 38
- Probable protein phosphatase 2C 67
- Homeodomain-like superfamily protein
- Probable protein phosphatase 2C 48
Sequence:
MGSIRGDLQPLFVMPPPPLDEDCDDIFNSDESSWGLLSLSCFGIIMGLWFFASVCLIFGVYGSETVWLGPNSSILVKPSSIFVKSINAKELDFSKPGLQLYGFNGQSTPSGYFVNWTESRVLSVSQNSYKGWPYYLNRGTHMNISYNILPKGSAVRLVITEGMPFFYRSSLKDIAFRDTAWSWNLIQGSGMIQLDISKSKGYYLTVANLKRKDVEVELDIDVKVVLYDTKQSSYNCSFSNGECSFKMNERSPVENYAVVTSPALGQGVSIDDEWYIELSYQPRLIAYGSFTGVLLSFMLVAIHFCNKLKCCGGEGFLSEDDSVRTCLLADKGDNDCCNDVEASNKSLCAICFDAPRDCCFLPCGHCVSCYQCGTKIKRTKGRCPICRKKIMHVKRIYTA