wanglab/gogpt-training-data huggingface dataset:
Protein: Probable cytosolic Fe-S cluster assembly factor SPAC806.02c (Q9UT57)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Fusion protein of two essential components of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. May form a heterotetramer with nubp35, functioning as a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- MIP18 family protein C144.16
- DNA repair/transcription protein mms19
- Cytosolic Fe-S cluster assembly factor NAR1 homolog
- General transcription and DNA repair factor IIH helicase subunit XPD
- DNA polymerase delta catalytic subunit
- Protein NIF3 homolog
Sequence:
MDKVQHVILVLSGKGGVGKSSVTTQLALSLHDSKVYSRPLKTGILDIDLTGPSIPRMFGKDAERNRIHQSSAGWVPVYTDETKEIGLMSLGFLLTSKNDSVVWRGPKKAAMIRQFISDVSWGELDFLIIDTPPGTGDEHLTIVESLLSETSTVRDVPIDGAVIVTTPQGIATLDVQKEIDFCKKASIKILGIVENMSGYICPHCADCTNIFSSGGGLTLSEKYKLPFLGSVPIDPKFGEMIENLTPDSNIVHLYSKTEMSKKFSFITNEFLNQLYGPRKLDTITTISGHTGRLWSVAAHPMLPLFATSSQDKSVRIYNSNTYNLVHVIDGFHTRSIRRVAWRPIERPVLAVASFDSVVSINEKIDDDWECTAALEGHENEVKCIAWSCNGNYLATCSRDKSVWIWEATEDDEFDCLAVLQEHTQDVKVVTWHPTEDLLVSGSYDNSICFWRDDGDDWALTCQLQGHTNTVWALAFSPNGNTLASADNDGNVFLWIKISSNEDVATIDSTNILRPALQEEWKQQTSLPHIHKGAVYTISWMNDATLCSAGGDGKIVVYQREKHDEALWHVAYEQDHAHGVYEINSLEYLRDDRLLSGGDDGECRVWSFK
Protein: Twinfilin-2 (A6-related protein) (mA6RP) (Twinfilin-1-like protein) (Q9Z0P5)
Organism: Mus musculus (Mouse)
Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19955359}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000269|PubMed:19774077, ECO:0000269|PubMed:19955359}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. Isoform 2 found also along myofibrils in cardiomyocytes (PubMed:18837697). Localized in cochlea hair cells to the tips of the middle and short rows of stereocilia (PubMed:19955359). {ECO:0000269|PubMed:18837697, ECO:0000269|PubMed:19955359}.
Interaction partners:
- Epidermal growth factor receptor kinase substrate 8-like protein 2
- F-actin-capping protein subunit beta
- Gelsolin
- Espin
- Whirlin
- Unconventional myosin-XV
- Epidermal growth factor receptor kinase substrate 8
- Myosin-IIIa
- Espin-like protein
- WD repeat-containing protein 82
Sequence:
MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSLAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTEPTNVAQLPSRIPRDAARYHFFLYKHTHEGDALESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFQLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGEDS
Protein: Transcription factor Sp6 (Epiprofin) (Krueppel-like factor 14) (Q9ESX2)
Organism: Mus musculus (Mouse)
Function: Promotes cell proliferation. Plays a role in tooth germ growth.
Subcellular location: Nucleus {ECO:0000269|PubMed:14551215}.
Interaction partners:
Sequence:
MLTAVCGSLGSQHTDAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGTEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQPALGGYVGDHQLCAPPPHPHPHHLLPAAGGQHLLGPPDGAKALEAAAQESQGLDSSLDAASRPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAAAAQGEGKAGGVVEPPGGKGKREAEGSSASSN
Protein: Small ribosomal subunit protein eS25w (40S ribosomal protein S25-4) (Q9T029)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS19z
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS21z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS12z
- Small ribosomal subunit protein uS2z
- Small ribosomal subunit protein eS1z
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein eS6y
Sequence:
MAPKKDKVPPPSSKPAKSGGGKQKKKKWSKGKQKEKVNNMVLFDQATYDKLLTEAPKFKLITPSILSDRMRINGSLARRAIRELMAKGVIRMVAAHSSQQIYTRATNT
Protein: DUF4201 domain-containing protein (Q57XK9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTTALSSAKNARSPGSNAAVSPGSKSVSLREGALRSDRKSTRELSPQSELKSDRKSMREISHSELKSDRKSTRELSPQSELKSDRKSMSGVSPQSELKSDRKSMREISHSELKSDRKSTRELSPQSELKSDRKSVRDSEMRSAGKSGRSVEARYGVRDDGDGEWSELGSEVTSELRSKAKSGRRSERRQGGADEFELSESDVDAHGENFFDSSRRSDRQPSSGAPEEEEETEEQIIIRLREELREFEAYEEEMQPNLNMYEEVIELRREAEQLEDDRKRALLQIDLGDISSYYDGDVEREVEELEAAVENSYLQACWTKERQRYIARNETDLPEWWRVDIMKLGFRLREAKRSFDSSNRVAQDLYRAHEVKVNATTDSRDKAKAELRQEIAAELNELRQRRERLLVIDKEQRFHLRRGTHVKELQVTSKRRQDALEARVVGEENRHFGASVELKRTVKDLEMELIQLRRELKDAKVSGESIVQELRKHLLDVTRSGEEVRKARQDYEEENSDLMSLKHELQCVLHYIRVRAREANY
Protein: RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein) (P0CJ62)
Organism: Xenopus laevis (African clawed frog)
Function: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of rbpj/rbpsuh, thereby preventing the interaction between rbpj/rbpsuh and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21102556}. Nucleus {ECO:0000269|PubMed:21102556}. Note=Shuttles rapidly between the cytoplasm and the nucleus.
Interaction partners:
Sequence:
MPDNLYATNMSLDLSITGHSTALPQRKSRSTYRFKAANSYVDESLFGSSGVRVDQTLQWNTAPPSQTPLLWSPGEIKENKKTSSCRPKSTPAGTPRKKIQYRVKSRTPSYCDESLFGGKVEECTWDAPWVKKEDTVKIRPLLWSPSPRLVQQSSMQNAKQGPLRAVHPPETSDSPLGTHKGLGAFWKPPESDSDYSPSPFSARQRQSTPGRETVRSASCSGRVTARRGSVKMQERPPWK
Protein: Bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase (A0A1D8PE67)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Phosphoribosylaminoimidazole carboxylase
- Phosphoribosylglycinamide formyltransferase
- Phosphoribosylformylglycinamidine synthase
- Amidophosphoribosyltransferase
- Adenylosuccinate lyase
- Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
- Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Adenylosuccinate synthetase
- Serine hydroxymethyltransferase, cytosolic
- Glycine cleavage system P protein
Sequence:
MSLNILVIGNGGREHAIVWRLLQSPTVNHIYVAPGNGGTISESSSSKITNVPISSSPKDFNKLQQFAVENKINLVIPGPEQPLVDGIADIFYAVGIPVFGPSAKAAKMEGSKAFSKEFMDKHNIPTARFQNFTDVAKAKEHIQSIDYKIVLKADGIAAGKGVLIPETTEEALQGLNEIMVDKNFGDAGNEIVIEEFLEGDELSILTITDGYSFYNLPAAQDHKRIGDGDKGLNTGGMGAYAPAPIATQDVLKKINDQIIKPTIDGMRKDGFPMCGVLFTGIMLSPTKEPKVLEYNVRFGDPETQTVLPLLSENTDLAQVMLAAAQHRLDSVTIETKPLYSTTVVMAAGGYPEAYGKGDEITIKKPLPQDTFIFHAGTSVNDQGKIVTSGGRVIASTAIAETLRQSVDKAYVGVNEHVSFNKKYNRKDIAHRAFRDADKAASAGSGSGSGVTYADAGVSVDNGNLLVENIKAKVKSTARPGADSDIGGFGGLFDLKKAGYNTDDTLLVAATDGVGTKLRIAQIMNIHNTVGIDLVAMNVNDLVVQGAEPLIFLDYFATGKLDIEVAAQFVDGVANGCIQAGCALVGGETSEMPGMYDEGHYDTNGTAVGAVLKDKILPQINNMKSGNVLIGLKSDGIHSNGFSLVRKIIEISEYEYQSPAPWKQGSTIGEEVLVPTKIYVKQLLSSINQGLLLGLAHITGGGLVENIPRALPKHLQATVDIEQWQVPEIFKWFGKQGNVPYEDILKTFNLGIGMVLIVEKENVDKVLKNLEESGEKDAVVIGELVERKQGEPGCVVNNIDGLY
Protein: Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) (Q7Z698)
Organism: Homo sapiens (Human)
Function: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:34626534}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q924S7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q924S7}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:15580519}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:15580519}. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules. {ECO:0000269|PubMed:15580519}.
Interaction partners:
- Sprouty-related, EVH1 domain-containing protein 1
- Neurofibromin
- Next to BRCA1 gene 1 protein
- GTPase KRas
- Fibroblast growth factor receptor-like 1
- Protein sprouty homolog 4
Sequence:
MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIHGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIEDLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTLGHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRRKEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA
Protein: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (F7A19.21 protein) (Putative dioxygenase) (Q9XI75)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Aldehyde dehydrogenase family 3 member H1
- Aldehyde dehydrogenase family 3 member F1
- Nitrilase 3
- Aldehyde dehydrogenase family 7 member B4
- 2-oxoglutarate-dependent dioxygenase DAO
- Nitrilase 2
- Aldehyde dehydrogenase family 2 member B4, mitochondrial
- Indole-3-acetaldehyde oxidase
- Amidase 1
- Probable amidase At4g34880
Sequence:
MGELNGVIIPTIDLEEVSDKILNQKIREASERWGCFRVINHGVSLSLMAEMKKTVIDLFQRPYEVKVRNTDVLLGSGYRAPNEINPYYEALGLYDMASPHAVNTFCDQLEASADQREIMVKYAKAINGLATDLARKLAESYGLVETDFFKEWPSQFRINKYHFKPETVGKLGVQLHTDSGFLTILQDDENVGGLEAMDNSSGTFFPIDPLPNTLAINLGDMATIWSNGRLCNVKHRVQCKEATMRYSIASFLLGPMDTDLEPPSEFVDAEHPRLYKPISHEGVRNIRMTKKLHDGEALKLITHAGLDK
Protein: Cytochrome b5 domain-containing protein RLF (Protein REDUCED LATERAL ROOT FORMATION) (Q9LXD1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the control of lateral root (LR) formation. Acts a positive regulator of early cell divisions involved in LR initiation, independently of ARF7 and ARF19-mediated auxin signaling.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:20230485}.
Interaction partners:
- Aberrant root formation protein 4
Sequence:
MDTSRDDDFTFSKVSPPDSEVKDLASDVGSITLKDGLDQQKSNGLIWKDKSLPPKEETIGSLSFTVTDSSSSKKQSNESSETFKTPARKPITRTKVPFEKGYSQMDWLKLTRTHPDLAGLKGESNKRLIPMDEVKKHRTGDSMWTVLKGRVYNISPYMNFHPGGVDMLMKAVGRDGTLLFNKYHAWVNVDILLEKCLVGVLDDTKVKKQEP
Protein: Claudin-18 (Q5I0E5)
Organism: Rattus norvegicus (Rat)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier. Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity).
Subcellular location: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Cell membrane {ECO:0000250|UniProtKB:P56857}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU060637}.; SUBCELLULAR LOCATION: [Isoform A1.1]: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}.
Interaction partners:
- Occludin
- Tight junction protein ZO-1
- Claudin
- Claudin-16
- Claudin-15
- Claudin
- Tight junction protein 3
- Claudin
- Claudin 34D
- Claudin
Sequence:
MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVQQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGVIGILVSIFALKCIRIGSMDDSAKAKMTLTSGIMFIISGVCAIIGVSVFANMLVTNFWMSTANMYSGMGGMVQTVQTRYTFGAALFVGWIAGGLTLIGGVMMCIACRGLTPDDRNFKAVSYHASGQNVAYKPGGFKASTGFGSNARNKKIYDGGARTEDDEQSHPTKYDYV
Protein: biotin--[biotin carboxyl-carrier protein] ligase (EC 6.3.4.15) (P96884)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVSAGDVVHLR
Protein: SPARC-like protein 1 (Matrix glycoprotein Sc1) (P24054)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- C-type lectin domain family 14 member A
- Cysteine and tyrosine-rich protein 1
- Pleiotrophin
- Myocilin
Sequence:
MKAVLLLLYALGIAAAVPTTFLSDHSNPTSATLPTLEDATVPTVPAEAAADIEKHPNHKAEKPSALNSEEEAHEQSTEQDKTYSFEVDLKDEEDGDGDLSVDPTERTLDLQEGTSEPQQKRLPENADFPATVSTPFVDSDQPANITKGEESQEQPVSDSHQQQDESGKQTQDSMTEESHKQDPGIPNEEKEEEEDPEDVGAPSDNQEEEKEPPEEQPTSKWEGNGDQSEDILQESSQPTQISKTKNDFEQGSQGQEGDSNAEGEDKAAGSKEHLPHTEWQGQEGRAGLDAIGNRKDTDEEKAVSTEPTDAAVVPRNHGASDNGGGDDSKHGASDDYFIPSQEFLEAERMHSLSYYLKYGEETPDESENRSEAGDNQGAKKAESSPNAEPSDEGNSRGHSADSCMNFQCKRGHTCKTDQHGKPHCVCQDPETCPPAKILDQACGTDNQTYASSCHLFATKCMLEGTKKGHQLQLDYFGACKSIPACTDFEVAQFPLRMRDWLKNILMQLYEPNPKHGGYLNEKQRSKVKKIYLDEKRLLAGDHPIELLLRDFKKNYHMYVYPVHWQFNELDQHPADRILTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDENLLF
Protein: At2g37400 (Chloroplast lumen common protein family) (Tetratricopeptide repeat (TPR)-like superfamily protein) (Q9ZUS6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein eL38z/eL38y
- At1g43860
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein uL24z
Sequence:
MESLGKLQLHQQPNHLSFTHFSSSFPKKPSSFSLRSLPRSTSSFKCISIKASSSKSQDSKLSILKSTCVSFTAAAALFLVNLQLKPSPAIAAPVAATPLMESLKQSNGNVSFEEEERSLEEYLASHPDDVEALRSLMEVRIKSRKLLEAIELIDRLIELEPEEKEWPMLKANIFSYSGDLESAKTGFEEILVKDPLRVEAYHGLVMAYSDSGDDLNAVEKRIEEAMVRCKKEKNRKDLRDFKLLVAQIRVIEGKHNEALKLYEELVKEEPRDFRPYLCQGIIYTVLKKENEAEKQFEKFRRLVPKNHPYREYFMDNMVASKLFAEKVQREMAE
Protein: Vacuolar-sorting protein dot2 (Defective organization of telomere protein 2) (ELL-associated protein of 30 kDa homolog dot2) (O94663)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Negatively regulates meiotic spindle pole body maturation via indirect regulation of the pcp1 gene. Required for efficient entry into pre-meiotic S phase.
Subcellular location: Cytoplasm. Nucleus. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Vacuolar protein-sorting-associated protein 36
- Vacuolar protein-sorting-associated protein 25
- Vacuolar protein sorting-associated protein 20
- Vacuolar-sorting protein snf7
- ESCRT-I complex subunit vps23
- Meiosis protein mei2
- RNA binding exosome specificity factor Mmi1
- Vacuolar protein sorting-associated protein 28 homolog
- ESCRT-III complex subunit did4
- Vacuolar protein sorting-associated protein 27
Sequence:
MRKRIGIGALNDDEYLKQYEEVGNELIEQQSDEIASQLSTFQEALKTFAREHATEIKQNSQFRNTFVKLALKIGLDPFVSGSDESAWAAVGMNEFYYQVAVRVIEVCYATQMENGGLLSVSQVCRFLNEENEAFGHEWLRETDVVRAVDSLAPLGPGFVLEKIAGKQYIRSLPLELNTDQNVVLEAVEILGYVTISILRDNYAWERSRCIQVLNDLVSKSLLWIDSQGVEMAYWGASNLIDDQAQRFLYENF
Protein: Tol-Pal system protein TolA (P19934)
Organism: Escherichia coli (strain K12)
Function: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. The Tol-Pal system is also required for polar localization of chemoreceptors clusters. The system also appears to be required for the activity of several outer membrane-localized enzymes with cell wall remodeling activity. Is involved in the uptake of group A colicins (colicins A, E1, E2, E3, and K) and in the uptake of filamentous phage DNA.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:2068069, ECO:0000269|PubMed:2687247}; Single-pass membrane protein {ECO:0000269|PubMed:2687247}. Note=Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity. {ECO:0000269|PubMed:17233825}.
Interaction partners:
- Tol-Pal system protein TolR
- Tol-Pal system protein TolB
- Tol-Pal system protein TolQ
- Cell division coordinator CpoB
- Outer membrane porin F
- Lipopolysaccharide export system protein LptC
- Acyl-CoA thioester hydrolase YbgC
Sequence:
MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQAEEAAAKAAADAKAKAEADAKAAEEAAKKAAADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAAEKAAADKKAAEKAAAEKAAADKKAAAEKAAADKKAAAAKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNASPAGSGNTKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP
Protein: UPF0283 membrane protein YcjF (P0A8R7)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Ras-like GTPase YcjX
- Chaperedoxin
- Sensor histidine kinase GlrK
- Chaperone protein ClpB
- UPF0716 protein FxsA
Sequence:
MTEPLKPRIDFDGPLEVDQNPKFRAQQTFDENQAQNFAPATLDEAQEEEGQVEAVMDAALRPKRSLWRKMVMGGLALFGASVVGQGVQWTMNAWQTQDWVALGGCAAGALIIGAGVGSVVTEWRRLWRLRQRAHERDEARDLLHSHGTGKGRAFCEKLAQQAGIDQSHPALQRWYASIHETQNDREVVSLYAHLVQPVLDAQARREISRSAAESTLMIAVSPLALVDMAFIAWRNLRLINRIATLYGIELGYYSRLRLFKLVLLNIAFAGASELVREVGMDWMSQDLAARLSTRAAQGIGAGLLTARLGIKAMELCRPLPWIDDDKPRLGDFRRQLIGQVKETLQKGKTPSEK
Protein: Phosphatidate cytidylyltransferase (EC 2.7.7.41) (Q8ILZ6)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- phosphatidate phosphatase
- Diacylglycerol kinase
- diacylglycerol kinase
- 4-hydroxybenzoate polyprenyltransferase, putative
- Glycerol-3-phosphate 1-O-acyltransferase
- 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative
- Mitochondrial cardiolipin synthase, putative
- Phospholipid/glycerol acyltransferase domain-containing protein
Sequence:
MPRKNSKTMTNKCANSNSNDFIEDKVLDDKKRKKSTESSTVDEKGDIIKRRSKSKSLDDSNGGIENMDKVKVSNNNRKKKSETMINNDNNNDNDDIKSMNHMNSMTHTNSTNHTNNMDNMDNMDNVNNMDDVNNMNNVNNMKNNINDEVYKLGSFEYEEECKKRNIRNSECKRRRNLKDMKYFKDIKPLKDFVNLKNSNNNNNTNQHNSGIFSNFTRFYGYNNKNSFNSNRSKQSTCSNSNLQNNMNLVNSESFESKLQTFKVRSQWTFILILLYFIILAAGHFYCSILVLILVTTLYKEIISLKSIENKDKKLPEIFYIRWYWFFLTIMTLGIPWVIPKLKHQIPLYKFLLTYHSINMFILAFVGFVWFILSLRKFSLKYQFSQIGIILLSSLFIVTQSLMHIANIYSGMIWFIVPVSSVVINDIFAYVFGILFGKTRLIQLSPKKTVEGYVGSSIITIVWGILITYFLQRYKFFICPQKYITFQPFVSWNYIDCDINPIFQQKVYEVPKQISQILSIKNIYYSKMIFHGLMLSLFAAFLAPFGGFFASGFKRALKIKDFGKSIPGHGGVTDRFDCQIFIGMFTYIYMKTFVKIKGGIYSYDLIIESIQKLDHKEIIRLFNQLKNIVDKKRRKQCTDNNTNDIHTRKDKRSNIDKPCTDKNKIPNK
Protein: F420-dependent formate dehydrogenase subunit beta (EC 1.17.98.3) (P06130)
Organism: Methanobacterium formicicum
Function: Catalyzes the oxidation of formate.
Interaction partners:
- Hydrogenase iron-sulfur subunit
- F420-dependent formate dehydrogenase subunit alpha
- CoB--CoM heterodisulfide reductase iron-sulfur subunit A
- CoB--CoM heterodisulfide reductase subunit C HdrC1
- CoB--CoM heterodisulfide reductase subunit B
- Formylmethanofuran dehydrogenase subunit D FwdD
- formylmethanofuran dehydrogenase
- Formylmethanofuran dehydrogenase subunit B FwdB
- Formylmethanofuran dehydrogenase subunit G FwdG
- Formylmethanofuran dehydrogenase subunit A FwdA
Sequence:
MINTNDMFYAKSSDAEIAEAGEYGGAVTTLLKFLLKEGIVDAVLAVDSSADLYDVVPILIEDPEDVVKAAGSLHFGTLNLAKVVTRYLDGAQDMKIAVTVKPCDAMTMVELMKREKVNADNVIMVGLNCGGTMPPVKGRQMMEEFYEVDPDSVVKEEIAKGKLIVETEDGTEKEIPIDELEDEGFGRRTNCRRCEVNIPRMADLACGNWGVIGPLAGKATFIEVCSPKGAEVLEKAKEAGVIDLEDPIPKGIEIREKIDGAMVKLADKWQGNDWEDKAGREIFSVLTEYMDDFSRCLKCYGCREACPICYCEDCCLEANNGPDWLSKGEIPPSPMFHLERMLHMVESCTNCGQCEEVCPGEIPLAKIWHEVNAKMKDTFGYVKGTGDEKPPIAYFPVGK
Protein: Monothiol glutaredoxin-3 (Q9Y7N3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Uncharacterized bolA-like protein C8C9.11
- Monothiol glutaredoxin-4
- Uncharacterized bolA-like protein C4B3.11c
- Monothiol glutaredoxin-5
- UV-induced protein uvi31
- Iron-sulfur cluster biogenesis chaperone, mitochondrial
- Iron-sulfur assembly protein 2
- Iron-sensing transcriptional repressor
- CCAAT-binding factor complex subunit php4
- Transcriptional activator hap2
Sequence:
MANRKIFLITSLIISLLLIHIFIFSPLNEPEKNAKAGPLGLSDVSVPSAPKLPAKDSTDFEVFLENPVIIFSRPGCPYSAAAKKLLTETLRLDPPAVVVEVTDYEHTQELRDWLSSISDISTMPNIFVGGHSIGGSDSVRALYQEEKLQSTLDEWTHNKVLILPTD
Protein: Ganglioside GM2 activator (A0A8I6A5G9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKLIPLLKRLFSLFIDLYTMYLYCIQSHIPLQSITIFFSFSFFRSWGPNPGPCPSQLGGFSWDNCDEGKDPAVIKSLTLQPDPIVVPGDVIVSAEGKTSIPLTSPQKVELTVEKEVAGFWVKIPCVEQLGSCTYENVCDLIDQYIPPGETCPEPLHTYGLPCHCPFKEGTYSLPSSNFTVPDLELPSWLSTGNYRIQSILSSGGKRLACIKIAASLKGK
Protein: Protoporphyrin uptake protein 1 (P40100)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in inducible protoporphyrin IX influx and heme efflux.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein YDR124W
Sequence:
MSTTDSGFVLYHYTPSKAAAIVFVVLFIIMTVIFAVQTLYAARKSSKALKNNPFESSDDKVDSLEDAEYKQLKITPTVFAFIPFFTGCIMEAVGYIGRALSSSNPERTTPYIIQSVLLLVAPALIAATIYMIFGRLLHVMRCQSLILISARFGTTFFVVGDVFSFFLQAAGGGLMSKAGSTKTGSGLITAGLFVQVIFFGFFIINEIRFTVNVKRRCLFYEDISRKWIFVNATLLLSSMLILLRSIVRIVEFIQGFNGYIISHEYFIYVFDAVPMLLVIIAFSVGSFFGNVFDVIKECQTLSN
Protein: Proprotein convertase subtilisin/kexin type 6 (F6XJP7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPPRAPPAPGPRPPPRAADVARGAGAAGRHGLPPLALRPWRWLLLLALPAACSALPPPRPVYTNHWAVQVLGGPGAADRVAAAHGYLNLGQIGNLDDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQARSDSLYFNDPIWSNMWYMHCTDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHVCVATADKRPRSIPIVQVLRTTALTNACADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLLDFSNEGFTNWEFMTVHCWGEKAEGEWTLEVQDIPSQVRNPEKQGKLKEWSLILYGTAEHPYRTFSSHQSRSRMLELSVPEQEPPKAAGQPPQAETPEDEEEYTAPSIQGSPNTLQTSVCHPECGDKGCDGPNADQCLNCVHFSLGNSKTNRKCVSECPLGYFGDAAARRCRRCHKGCETCTGRSPAQCLSCRRGFYHHQETNTCVTLCPAGLYADESQRLCLRCHPSCQKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELVKCGECHHTCRTCVGPSREECIHCAKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCEENCLSCEGSSRNCSRCKAGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG