wanglab/gogpt-training-data huggingface dataset:
Protein: Beta carbonic anhydrase 1, chloroplastic (AtbCA1) (AtbetaCA1) (EC 4.2.1.1) (Beta carbonate dehydratase 1) (Protein SALICYLIC ACID-BINDING PROTEIN 3) (AtSABP3) (P27140)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Reversible hydration of carbon dioxide. Required for photosynthesis in cotyledons. Binds salicylic acid. Together with BCA4, involved in the CO(2) signaling pathway which controls gas-exchange between plants and the atmosphere by modulating stomatal development and movements. Promotes water use efficiency.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:17407539}. Cell membrane {ECO:0000269|PubMed:20010812}; Peripheral membrane protein {ECO:0000269|PubMed:20010812}.
Interaction partners:
- Cyanate hydratase
- Alpha carbonic anhydrase 1, chloroplastic
- Gamma carbonic anhydrase 1, mitochondrial
- Tubulin-folding cofactor D
- Serine/threonine/tyrosine-protein kinase HT1
- Regulatory protein NPR1
- Protein DETOXIFICATION 56
- Transcription factor TGA1
Sequence:
MSTAPLSGFFLTSLSPSQSSLQKLSLRTSSTVACLPPASSSSSSSSSSSSRSVPTLIRNEPVFAAPAPIIAPYWSEEMGTEAYDEAIEALKKLLIEKEELKTVAAAKVEQITAALQTGTSSDKKAFDPVETIKQGFIKFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFQPGDAFVVRNIANMVPPFDKVKYGGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNNSTDFIEDWVKICLPAKSKVISELGDSAFEDQCGRCEREAVNVSLANLLTYPFVREGLVKGTLALKGGYYDFVKGAFELWGLEFGLSETSSVKDVATILHWKL
Protein: Flagellar biosynthesis protein FlhA (O06758)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Involved in the export of flagellum proteins.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Flagellar biosynthetic protein FlhB
- Flagellar biosynthetic protein FliQ
- Flagellar secretion chaperone FliS
- Flagellum-specific ATP synthase
- Flagellar motor switch protein FliG
- Flagellar biosynthetic protein FliP
- Flagellar motor switch protein FliN
- Flagellar biosynthesis protein FlhF
- Flagellar assembly protein FliH
- Flagellar M-ring protein
Sequence:
MANERSKLAFKKTFPVFKRFLQSKDLALVVFVIAILAIIIVPLPPFVLDFLLTISIALSVLIILIGLYIDKPTDFSAFPTLLLIVTLYRLALNVATTRMILTQGYKGPSAVSDIITAFGEFSVSGNYVIGAIIFSILVLVNLLVVTNGSTRVTEVRARFALDAMPGKQMAIDADLNSGLIDDKEAKKRRAALSQEADFYGAMDGASKFVKGDAIASIIITLINIIGGFLVGVFQRDMSLSFSASTFTILTIGDGLVGQIPALIIATATGIVATRTTQNEEEDFASKLITQLTNKSKTLVIVGAILLLFATIPGLPTFSLAFVGTLFLFIAWLISREGKDGLLTKLENYLSQKFGLDLSEKPHSSKIKPHTPTTRAKTQEELKREEEQAIDEVLKIEFLELALGYQLISLADMKQGGDLLERIRGIRKKIASDYGFLMPQIRIRDNLQLPPTHYEIKLKGIVIGEGMVMPDKFLAMNTGFVNKEIEGIPTKEPAFGMDALWIETKNKEEAIIQGYTIIDPSTVIATHTSELVKKYAEDFITKDEVKSLLERLAKDYPTIVEESKKIPTGAIRSVLQALLHEKIPIKDMLTILETITDIAPLVQNDVNILTEQVRARLSRVITNAFKSEDGRLKFLTFSTDSEQFLLNKLRENGTSKSLLLNVGELQKLIEVVSEEAMKVLQKGIAPVILIVEPNLRKALSNQMEQARIDVIVLSHAELDPNSNFEALGTIHINF
Protein: Calcium up-regulated protein G (Q7Z1Z9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May play an important role in stabilizing and/or regulating the cell membrane during Ca(2+) stress or certain stages of development.
Subcellular location: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MINIEDISKSSNQSEEKQLKSTSSKPKYSFAAKSLFKGSNNITPYYLSTSNTFQCVASESIQTWLLSDDGHIFTSSGNFVLDVSSGGYFVELVQLNSNSKTQIWTIDTTNNKIQNQGNGNYLDIDCFNICVAPLNGNATQQWTTFRRAPIPTGNWGYFQSKQLNSNNYWGLSVLNNSTSYNTSVVMNKVQAKSKGQIWQMTSDGHILSRLDGNLVLDIGPSINGSTTNYYLNTNVYKANDLMQQWGINENNQIFNQYYPNLCIGFVGQLGVDSTVNCVLAQPSSACDTYFQFIANPTYSLNQIVGEVPEPFPAYTSGDLLASYQYLSNDATSNFTDDIRSLYTGINVSLQSFLSIVTNATCPSSIHSTEDFSNVQNQIKTELIYAINVRLVFENYSGFYSKLFSQGSSNLTNLANLINVDMSSNQMVNANYTDAITSIFYSLISEIPVGGPIIANIGQSAVEFGELMSQSNYQGASTYQVELSQLYTHLNTNYENEMANAQSMKDTILQDWGMMSKTYALCFLPTNDPSSLNMNGLDFDEISDVASVAYEIAMIQMLLPTTYQIYFTPAGYWVPYSDGDFAYSDNSGTYIMATIEYSNSYPPKELTDKLWNNGVSKQEFFLSAYGWNLATSLTYYNNTKQHNNIFKLAFPTIKNFTGVPMQFVMTNEGDNLGNFTVKTHFAKFFSTYYSCGEAGHHYFDIAVTDINKNKVANFTVDIKLKALEGSYVSIKTGSLVVQPGYAVGNPICNQGSYSLMFSASILIPIYKSE
Protein: Carcinine transporter (Q9VIK2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Carcinine transporter which is required for recycling of the neurotransmitter histamine in photoreceptor neurons of the compound eye. Following histamine release from photoreceptors and its uptake by glia where it is converted to carcinine, required for the uptake of carcinine from glia into photoreceptor cells where it can be hydrolyzed by tan to form histamine and beta-alanine.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:26653853, ECO:0000269|PubMed:26713872}. Note=Expressed predominantly in photoreceptor axon termini. {ECO:0000269|PubMed:26653853, ECO:0000269|PubMed:26713872}.
Interaction partners:
- Sodium- and chloride-dependent GABA transporter ine
- Beta-alanyl-bioamine nonribosomal peptide synthetase ebony
- Histidine decarboxylase
Sequence:
MSDIEDNDGDEYDELSELRQRHKPESQPSVDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNASWPLIKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQPASYENLDVLAGSSTNASEVELELRDSRRVREPAPRIDERTPLDTTASGSGRPVHRPSMKRLVRQMSVMDTQRTHDGTMQLTHWI
Protein: TBC1 domain family member 23 (Q8K0F1)
Organism: Mus musculus (Mouse)
Function: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (By similarity). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes which are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29084197}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9NUY8}. Note=Localization to the trans-Golgi (TGN) is regulated by ARL1 and ARL5B/ARL8. ARL1 increases Golgi localization, while ARL5B decreases it. Recruitment to the trans-Golgi network requires the presence of GOLGA1 and GOLGA4, but not that of FAM91A1 (By similarity). Recruited on AP-1-derived vesicles by WDR11 complex (By similarity). {ECO:0000250|UniProtKB:Q9NUY8}.
Interaction partners:
- WASH complex subunit 2
- Sorting nexin-27
- WASH complex subunit 3
- Protein FAM91A1
- WASH complex subunit 5
- WASH complex subunit 1
- DnaJ heat shock protein family
- WASH complex subunit 4
- TBC1 domain family member 20
- F-actin-capping protein subunit alpha-1
Sequence:
MAEGEELLPLSTSGGDSWEKDLEEALEAGGCDLETLRNIIQGRPLPAELRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLEFIEQLSVPEEKAAELLLDIESVITFYCKSRSVKYSTSLSWIHLLKPLICLQLPRSDLYNCFYAVMNKYIPRDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFAHYCSTEVTQAIWDGYLQQADPFFIYFLMLIILVNTKEVILAQESDSKEEVIRFLESTPASLNLEDIEDLFSLAQYYCSKTPASFRKDNHHLFGSTLLGIKDDEADLSQALCLAVSVSEILQANQLQGEGVRFFVVDCRPAEQYNAGHLATAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVEGPESGYGHWIASTSGSRGSISSVDGESCNGSNDRGMKSLVSKMTVALKTKSVTVREKVISFIENSSTPVDRHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDIKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATRAIKQQIMKVLDALES
Protein: Outer plastidial membrane protein porin (Voltage-dependent anion-selective channel protein) (VDAC) (P42057)
Organism: Zea mays (Maize)
Function: Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).
Subcellular location: Plastid outer membrane. Note=Found in non-photosynthetic root plastids only.
Interaction partners:
- Ubiquitin-like protein ATG12
- Putative transmembrane GTPase FZO-like chloroplastic
Sequence:
MVVAVGLYTDIGKKTRDLLYKDYNTHQKFCLTTSSPNGVAITAAGTRKNESIFGELHTQIKNKKLTVDVKANSESDLLTTITVDEFGTPGLKSIINLVVPDQRSGKLEFQYLHEYAGVNASVGLNSNPMVNLSGAFGSKALSVGVDVSFDTATSDFTKYNAALSLTSPDLIASLHLNNHGDTLVASYYHLVKNHSGTAVGAELSHSMSRNESTLIFGSQHSLDPHTTIKTRFNNYGMASALVQHEWRPKSFVTISGDVDTKAIEKSTKVGLSLVLKH
Protein: CRP-like protein Clp (Catabolite activation-like protein) (CAP-like) (Q4UZF6)
Organism: Xanthomonas campestris pv. campestris (strain 8004)
Function: Global transcriptional regulator that regulates virulence factors production by activating or repressing the expression of a large set of genes in diffusible signal factor (DSF) pathway.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MSLGNTTVVTTTVRNATPSLTLDAGTIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFIESDTREVILRTRTQCELAEISYERLQQLFQTSLSPDAPRILYAIGVQLSKRLLDTTRKASRLAFLDVTDRIVRTLHDLSKEPEAMSHPQGTQLRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVVLYGTR
Protein: BTB/POZ and TAZ domain-containing protein 4 (BTB and TAZ domain protein 4) (Q9FJX5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19054356}.
Interaction partners:
- Adenine nucleotide transporter BT1, chloroplastic/mitochondrial
- RING-H2 finger protein ATL13
- At5g40590
Sequence:
MVTGCVDLHQSFKSADSSSVPIPPPLPSKSDGLKKKLGHSSVSTATRDMWDRLFNDGYKADVVIYTDNGSIIYAHANILGTASTVIKGMLKQAKRHGKWHTISIRGVPHDAVRVFIRFLYSSCYEKEEMNEFIMHLLLLSHAYVVPQLKRVCEWHLEHGLLTTENVVDVFQLALLCDFPRLSLISHRMIMKHFNELSATEAWTAMKKSHPFLEKEVRDSVIIEANTRKERMRKRNDQRIYSQLYEAMEALVHICRDGCKTIGPHDKDFKPNHATCNYEACKGLESLIRHFAGCKLRVPGGCVHCKRMWQLLELHSRVCAGSDQCRVPLCRNLKEKMEKQSKKDESRWKLLVKNVLGSKKIGGSPFFLPVTNC
Protein: Protein ECERIFERUM 26 (CER2-like protein 1) (CER2-like1) (Q9SVM9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in biosynthesis of the epicuticular wax. Plays a role in very-long-chain fatty acid (VLCFA) biosynthesis and is required for C30 fatty acid elongation in leaf. Despite its classification as a BAHD acyltransferase based on sequence homology, CER26 does not seem to share the catalytic mechanism of the members of the BAHD family.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:23384041}.
Interaction partners:
- 3-ketoacyl-CoA synthase 9
- Very-long-chain 3-oxoacyl-CoA reductase 1
- Very-long-chain
- Very-long-chain enoyl-CoA reductase
- 3-ketoacyl-CoA synthase 5
- 3-ketoacyl-CoA synthase 6
- Very-long-chain aldehyde decarbonylase CER1
- Fatty acyl-CoA reductase 3
- Probable long-chain-alcohol O-fatty-acyltransferase 2
- Exosome complex component RRP45B
Sequence:
MGRSQEQGQGQGPVHSIRLSTVGATRPTETGTTHEPTGLDLAMKLHYLKAAYIYSAETARDLTVRHLKEAMFMLFDQIAWTTGRFSRRDSGRPYIKCNDCGTRFVEGQCNLTVEEWLSKPDRSVDEFLVYHHPIGPELTFSPLIYVQMTRFKCGGLGLGLSWANIIGDAFSLFYAFNLWAKAITGEKIYAPTTPSIGERRFQSPNPTVKDPVSIKRVEPVGDLWVTPNDKKLANYCFNLSVADQISPHFPAKGDDSIPVFEILAGIIWKCIAKVRVEPKPVTVTIIKKDPNDLKLNAIRNSQVISSVSVDFPVAEATVEELVKAMGEAKDERCGIEEIGESCDGNLDFVVYGAKLTFLDLTGEDLYEAKVMGKSPESVYCNVEGIGEEGLVVVYAAAKSEERVVTVTLPEEEMERVKLEFKKFGLIAP
Protein: Histone H2B.v3 (Q54LP8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H4
- PWWP domain-containing protein
- Histone H2A.z
- Histone H2AX
- Histone H3.3 type c
- Histone H3.3 type a
- Histone H3.3 type b
- Plus3 domain-containing protein
- Histone H2A.v1
- Histone H2A.v2
Sequence:
MVFVKGQKKATKGSTQSGEEKTASTTPKVTKTPTEGGEKKRKKRKSDYTSFSTYIHKLLKQITPPTNAKSNEKGDRKFTISSKAMSVMNSFVHDIFDRIATEASGLAKKKKRQTLHSRDIQVAVRIILTGELAKHAILQGMTAVNKYNPTESKN
Protein: ZIC family member 3 heterotaxy 1 (Odd-paired homolog, Drosophila) (Zinc finger protein) (Zinc finger protein of the cerebellum 3) (Q6PV84)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTMLLDSAPQFPSLGVGGFGTPRHHELGNRDPGLGLSPFADSSHSAAFKISPVTHDIASSQTSAFTPQATGYAAALGHHHGGQVGSYAGGAFNSTRDFLFRNRGAGIGETAPPSAQHGIFAASAGSLHGPPGISDNPGHLLFPGLHDQSVSHTSPGGHVVNSQMHLGLRGDIFGRPDPYRPVASPRTEPYGAAPLHNYNHPINMNMGMNVPTHHGPGAFFRYMRQPIKQELSCKWIDENQMNRPKKTCDRTFSTMHEMVTHVSMEHVGGPEQSNHVCYWEDCPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFDGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSESSPAASSGYESSTPPVLVSANTEDPTKTPTSAVQNSSAHSDGLPPNFNEWYV
Protein: Galectin-1 (Cgl-I) (Galectin I) (Q06100)
Organism: Coprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)
Function: Binds lactose. May play a role in fruiting body formation.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10931889}. Secreted, cell wall {ECO:0000269|PubMed:10931889}. Endomembrane system {ECO:0000269|PubMed:10931889}. Note=Detected in extracellular matrix, cell wall and cytoplasmic membrane-bound bodies.
Interaction partners:
Sequence:
MLYHLFVNNQIKLQDDFKAEAVATIRSSVFNSKGGTTVFNFLSAGENILLHISIRPGENAIVFNSRTKGGAWGPEERVPYAGKFKGPNPSITVLDHGDRFQILFDNATAIYYTKRIKENAAAIAYSAENSLFSSPVTVDIHGLLPPLPPA
Protein: NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family (Q95PW9)
Organism: Caenorhabditis elegans
Interaction partners:
- Serine/threonine-protein kinase pak-1
- Serine/threonine-protein kinase pak-2
- Ras-related protein rac-2
- Rac-like GTPase
- Protein sax-3
- WH1 domain-containing protein
- Cell division control protein 42 homolog
- CRIB domain-containing protein
- Tyrosine-protein kinase sid-3
- Serine/threonine-protein kinase max-2
Sequence:
MSEDYVVVKYDYLAQEEQELTIKKNERLKLLDDSKNWWKVMNDSNSVGFVPSNYVRKESIVDKAKGTIKGLARGRNRSSDPEPEERLNGIARLAFSLNNNCAVTPSSNKIPMMSSKTKAVVKFTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGVGWFPSNYVEEVEASTNGNQGSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEVVVALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARNASGTTGLVPRNYIEVVNDSSSSKASHQDFAPQYSGNGEIPMEQQPWYFGRISRERAEDLLLHGREGEFLVRDSESNPGDLSISMRGIERNKHFKVQNVDGLLKIGNRTFVDMNALINHYTTSPIFSSPTEKLFLTGPLPK
Protein: Oryza sativa mitochondrial plasmid-like gene (B1) for 2 ORFs (O47939)
Organism: Oryza sativa (Rice)
Interaction partners:
Sequence:
MGLAWCRGTKPRMIGTHITRFLKQPLALPGGCLAGVREDSEQPSNCGNWGTLCRHESDVIPDRNTGTKVFVKVFGIQQCWMSGTERSGTERVLGN
Protein: Transcriptional regulatory protein rxt2 (O94355)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative histone deacetylase complex subunit cti6
- Transcriptional regulatory protein sds3
- Transcriptional regulatory protein rxt3
- Chromatin modification-related protein png2
- Chromatin modification-related protein eaf3
- Histone deacetylase clr6
- Paired amphipathic helix protein pst3
- Transcriptional regulatory protein dep1
- Uncharacterized protein C2F7.07c
- Uncharacterized protein C16C9.05
Sequence:
MKQFEEQIERFKQALFEDSDASDSDSSIGEALTNRGLKRKKGSKNVYYGCVGNSSGSSIDIDYYNIGNTKRGVVSHFRRRIDPEWLDHDNPYNDINIAEIMSPLTKPQDLLTHPAISSIFEQNYLSILASSALEIISAEHKYTAHLEQLMVALLGDDPSLPGPPHEVFGISPEQCRELTITVQEALEKSKEFIRCWTNVRMDLLRAIRFKNKVIAYCQGEDYNGNTQVLSKNESDGKPNS
Protein: Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (E9PJF4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSFLKSFPPPGPAEGLLRQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHALSRDRSDCLGEHLYVMVNAKFEEESKEPVADEEEEDSDDDVEPITEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHDGMEVDTTPTVAGQFEDADVDH
Protein: Chaperone protein ClpC2, chloroplastic (EC 3.6.1.-) (ATP-dependent Clp protease ATP-binding subunit ClpC homolog 2) (AtClpC) (Casein lytic proteinase C2) (Q9SXJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Molecular chaperone. May act as a suppressor of FtsH-mediated thylakoid membrane biogenesis and may enhance photoinhibition. Seems not involved in chloroplastic protein import. Probable component of the TIC-associated stromal import motor involved in inner membrane translocation. Has an ATPase activity, but no ADPase activity. Interacts with transit peptides with a positional preference. Localization of the signal sequence at the N-terminal end of a protein seems mandatory for interaction to take place.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:10427773, ECO:0000269|PubMed:21737456, ECO:0000269|PubMed:24599948}. Plastid, chloroplast membrane {ECO:0000269|PubMed:21737456, ECO:0000269|PubMed:24599948}.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit 3, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 1, chloroplastic
- ATP-dependent Clp protease adapter protein CLPS1
- ATP-dependent Clp protease proteolytic subunit 6, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 5, chloroplastic
- ATP-dependent Clp protease proteolytic subunit 4, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 2, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 3, chloroplastic
- Chloroplastic ATP-dependent Clp protease proteolytic subunit 1
- ATP-dependent Clp protease proteolytic subunit-related protein 4, chloroplastic
Sequence:
MAWSIALLTPPFFGPGRHVQAKEYREPRGCVMKMSSLKAPVLRIQATEYREPRGRVKMMSSLQAPLLTIQSFSGLRAPSALDYLGRPSPGFLVKYKLAKSSGREKASRCVPKAMFERFTEKAIKVIMLSQEEARRLGHNFVGTEQILLGLIGEGTGIAAKVLKSMGINLKDSRVEVEKIIGRGSGFVAVEIPFTPRAKRVLELSLEEARQLGHNYIGSEHLLLGLLREGEGVAARVLENLGADPSNIRTQVIRMVGENNEVTASVGGGSSGNSKMPTLEEYGTNLTKLAEEGKLDPVVGRQPQIERVVQILARRTKNNPCLIGEPGVGKTAIAEGLAQRIASGDVPETIEGKTVITLDMGLLVAGTKYRGEFEERLKKLMEEIRQSDEIILFIDEVHTLIGAGAAEGAIDAANILKPALARGELQCIGATTIDEYRKHIEKDPALERRFQPVKVPEPTVEEAIQILQGLRERYEIHHKLRYTDEALVAAAQLSHQYISDRFLPDKAIDLIDEAGSRVRLRHAQLPEEARELEKQLRQITKEKNEAVRSQDFEMAGSHRDREIELKAEIANVLSRGKEVAKAENEAEEGGPTVTESDIQHIVATWTGIPVEKVSSDESSRLLQMEQTLHTRVIGQDEAVKAISRAIRRARVGLKNPNRPIASFIFSGPTGVGKSELAKALAAYYFGSEEAMIRLDMSEFMERHTVSKLIGSPPGYVGYTEGGQLTEAVRRRPYTLVLFDEIEKAHPDVFNMMLQILEDGRLTDSKGRTVDFKNTLLIMTSNVGSSVIEKGGRRIGFDLDHDEKDSSYNRIKSLVTEELKQYFRPEFLNRLDEMIVFRQLTKLEVKEIADIMLKEVVARLEVKEIELQVTERFKERVVDEGFDPSYGARPLRRAIMRLLEDSMAEKMLSRDIKEGDSVIVDVDAEGSVVVLSGTTGRVGGFAAEEAMEDPIPIL
Protein: Lipoate--protein ligase (EC 6.3.1.20) (LplA2) (P0DN72)
Organism: Streptococcus pyogenes serotype M5 (strain Manfredo)
Function: Catalyzes specifically the lipoylation of GcvH-L (SpyM50867), likely via the ATP-dependent activation of lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domain of the target protein.
Interaction partners:
Sequence:
MYLIEPIRNGKRITDGAVALAMQVYVQENLFLDDDILFPYYCDPKVEIGKFQNAVVETNQEYLKEHHIPVVRRDTGGGAVYVDSGAVNICYLINDNGVFGDFKRTYQPAIEALHHLGATGVEMSGRNDLVIDGKKVSGAAMTIANGRVYGGYSLLLDVDFEAMEKALKPNRKKIESKGIRSVRSRVGNIREHLAPQYQGITIEEFKDLMICQLLQIETISQAKRYDLTEKDWQQIDALTERKYHNWEWNYGNAPQYRYHRDGRFTGGTVDIHLDIKKGYIAACRIYGDFFGKADIAELEGHLIGTRMEKEDVLATLNAIDLAPYLGAITAEELGDLIFS
Protein: Putative ALA-interacting subunit 4 (AtALIS4) (Q9SA35)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- At4g01860
- Membrane lipoprotein
- Organic cation/carnitine transporter 6
- E3 ubiquitin-protein ligase listerin
- Wall-associated receptor kinase-like 8
- F3O9.7 protein
- Endoglucanase 7
- Extensin-like protein
- Metal tolerance protein 10
- Pentatricopeptide repeat-containing protein At1g71460
Sequence:
MSTKKHNLLANFASSDSRFTQQELPACKPILTPKWVILTFLVSGVVFIPLGVICLFASQGVIEIVDRYDTDCIPLSSRDNKVRYIQGLEDKRCNRTITVTKTMKNPVYVYYQLENYYQNHRRYVKSRQDGQLRSPKDEHETKSCAPEDTLGGQPIVPCGLVAWSLFNDTYDFTRNNQKLPVNKKDISWKSDRESKFGKNVFPKNFQKGSLIGGKSLDQDIPLSEQEDLIVWMRTAALPTFRKLYGKIDTDLQAGDTIKVLLQNNYNTYSFNGKKKLVLSTTSWLGGRNDFLGIAYLTVGSICLFLAVSFSVLYLAKPRQLGDPSYLSWNRSAGGGR
Protein: Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4) (P47879)
Organism: Mus musculus (Mouse)
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular location: Secreted.
Interaction partners:
- Insulin-like growth factor 1
- Insulin-like growth factor 2
- Pappalysin-1
Sequence:
MLPFGLVAALLLAAGPRPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGMRCYPPRGVEKPLRTLMHGQGVCTELSEIEAIQESLQTSDKDESEHPNNSFNPCSAHDHRCLQKHMAKIRDRSKMKIVGTPREEPRPVPQGSCQSELHRALERLAASQSRTHEDLFIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFQE
Protein: Serine/threonine-protein kinase cds1 (EC 2.7.11.1) (Checkpoint kinase cds1) (Q09170)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in the DNA replication-monitoring S/G2 checkpoint system. It is responsible for blocking mitosis in the S phase. It monitors DNA synthesis by interacting with DNA polymerase alpha and sends a signal to block the onset of mitosis while DNA synthesis is in progress. Phosphorylates rad60 and dna2.
Interaction partners:
- Mediator of replication checkpoint protein 1
- Protein kinase rad3
- DNA repair protein crb2
- Cell cycle serine/threonine-protein kinase hsk1
- Histone chaperone cia1
- Serine/threonine-protein kinase plo1
- M-phase inducer phosphatase
- Serine/threonine-protein kinase chk1
- Mitosis inhibitor protein kinase wee1
- Crossover junction endonuclease mus81
Sequence:
MEEPEEATQATQEAPLHVSQNIAKQVVNNENVFMKLVMTRMLDGKTEVIPLTTDVHNGFWRFGRHKSCEVVLNGPRVSNFHFEIYQGHRNDSDESENVVFLHDHSSNGTFLNFERLAKNSRTILSNGDEIRIGLGVPKDEISFLCQVPVKHSRDSQKNMIKSENSHYEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSLHHPGVVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLHLHKQGVTHRDIKPENILITNDFHLKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNVNLDGGYDDKVDIWSLGCVLYVMLTASIPFASSSQAKCIELISKGAYPIEPLLENEISEEGIDLINRMLEINPEKRISESEALQHPWFYTVSTHEHRTPPSSSEHEATEQLNSSS
Protein: 40S ribosomal protein L14, putative (Q383F5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 60S ribosomal protein L17, putative
- 60S ribosomal protein L28, putative
- 60S ribosomal protein L35, putative
- 60S ribosomal protein L13a, putative
- 60S ribosomal protein L27a
- 60S ribosomal protein L6, putative
- Ribosomal protein L37
- 60S ribosomal subunit protein L31, putative
- 60S ribosomal protein L35A, putative
Sequence:
MVKANYIRAGRLVRILRGPRQNRVGVIVDIVDANRVLVENPCEQKMWRHVQNLKNVEPLKFCVSISRNCSTKALKEALESKKVLEKYAATKSAVRIAAKKAFAESTDFERYQLRVAKRSRAYWARKIFDDNDKKNPVSWHKVALKKLLKNAKKVDSTPAAKKRVEKARAARKARLAAGKSKTKVAASKK