wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) (P62714)
Organism: Homo sapiens (Human)
Function: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16541025}. Nucleus {ECO:0000269|PubMed:16541025}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
Interaction partners:
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Immunoglobulin-binding protein 1
- Striatin
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
- MOB-like protein phocein
- Striatin-3
- Striatin-4
Sequence:
MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
Protein: 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) (O51509)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
- Glucose-6-phosphate 1-dehydrogenase
- Ribose-5-phosphate isomerase A
- 6-phosphogluconolactonase
- Chaperone protein HtpG
- Phosphoglycerate kinase
- Lipoprotein, putative
- Pyruvate kinase
- Enolase
Sequence:
MDVGIYGLGVMGSNLALNIADNGFNVSVYNRDNEKTEIFVKQNSHKKINGFKDIESFVKSLKTPKKIILMVTSSAIEKVIEQILPFMNKSDIIIDGGNSHYKSTMRLEKELFAKDIYFVGLGISGGERGARFGPALMYGGSKSAYEILEPMLNKIAAKTKNNDICSTYIGENGSGHYVKMIHNGVEYADMQLISEVYFFMKKAFNLDNLKISEVFEKWNEGDLSGYLLEITSKILKYKENNEYLVDKILDIANQKGTGVWTAIDALESGVPVNLIVESVFSRFMSGLKHERIIASDLLKMDTSSFEFELSDWILDLYYALLVSKIVAYAQGFMMLKTASVNYGWDLNLGKISLVWREGCIIRSSFLDKIKLAYDKNPHLINLLFDDYFLDLLKNNHKSLRRIISKASEIGIPLPAFYASLSFLDSYSTNYLPSNLIQAQRDFFGAHSFERLDSKRGEFFHSAWQ
Protein: Embigin (Q6PCB8)
Organism: Homo sapiens (Human)
Function: Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O88775}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O88775}. Synapse {ECO:0000250|UniProtKB:P21995}. Note=Localizes to the neuromuscular junctions. {ECO:0000250|UniProtKB:P21995}.
Interaction partners:
- Monocarboxylate transporter 2
- Monocarboxylate transporter 1
- Monocarboxylate transporter 4
- Monocarboxylate transporter 3
- Basigin
- Fibronectin
Sequence:
MRALPGLLEARARTPRLLLLQCLLAAARPSSADGSAPDSPFTSPPLREEIMANNFSLESHNISLTEHSSMPVEKNITLERPSNVNLTCQFTTSGDLNAVNVTWKKDGEQLENNYLVSATGSTLYTQYRFTIINSKQMGSYSCFFREEKEQRGTFNFKVPELHGKNKPLISYVGDSTVLTCKCQNCFPLNWTWYSSNGSVKVPVGVQMNKYVINGTYANETKLKITQLLEEDGESYWCRALFQLGESEEHIELVVLSYLVPLKPFLVIVAEVILLVATILLCEKYTQKKKKHSDEGKEFEQIEQLKSDDSNGIENNVPRHRKNESLGQ
Protein: Elongation factor 1-alpha (EF-1-alpha) (EC 3.6.5.3) (Elongation factor Tu) (EF-Tu) (O27132)
Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00118}.
Interaction partners:
- Fused uL13/uS9 ribosomal subunit protein
- Elongation factor 1-beta
- Small ribosomal subunit protein uS10
- Elongation factor 2
- Peptide chain release factor subunit 1
- Small ribosomal subunit protein eS1
- Protein pelota homolog
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS5
Sequence:
MAKEKEHMNLAFIGHVDHGKSTLVGHLLLQAGAIAEQQLAEGEDKFRFVMDRLSEERERGVTIDLAHAKFETDKYEFTIVDCPGHRDFVKNMITGASQADAAVLVVAVDDGVMPQTKEHVFLSRTLGINQLIVAINKMDLVNYDEEKFNALKDEVAALIKTVGYKPSDVEFIPLSAFEGDNITSKSENTPWYKGKTLVEALDDLEAPEKPVDLPLRIPIQDVYSITGVGTVPVGRVETGVLKKGENVIFEPAGVSGEVKSIEMHHEMIEQAEPGDNIGFNVRGVGKNDIRRGDVAGHLDNPPKVAKEFTAQIVVLQHPGVITVGYTPVFHCHTAQVACTFLELVQKMNPATGQVEEENPDFLKTGNAAVVKVKPTKPLVIEKIKDIPHMGRFAIRDMGQTVAAGMCIDLVPAK
Protein: ATF/CREB activator 1 (P39970)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources. Regulates the expression of COS8. Has efficient silencing blocking activities.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Interaction partners:
- General control transcription factor GCN4
- Chromatin assembly factor 1 subunit A
- Adenylyl cyclase-associated protein
Sequence:
MDYKHNFATSPDSFLDGRQNPLLYTDFLSSNKELIYKQPSGPGLVDSAYNFHHQNSLHDRSVQENLGPMFQPFGVDISHLPITNPPIFQSSLPAFDQPVYKRRISISNGQISQLGEDLETVENLYNCQPPILSSKAQQNPNPQQVANPSAAIYPSFSSNELQNVPQPHEQATVIPEAAPQTGSKNIYAAMTPYDSNIKLNIPAVAATCDIPSATPSIPSGDSTMNQAYINMQLRLQAQMQTKAWKNAQLNVHPCTPASNSSVSSSSSCQNINDHNIENQSVHSSISHGVNHHTVNNSCQNAELNISSSLPYESKCPDVNLTHANSKPQYKDATSALKNNINSEKDVHTAPFSSMHTTATFQIKQEARPQKIENNTAGLKDGAKAWKRARLLERNRIAASKCRQRKKMSQLQLQREFDQISKENTMMKKKIENYEKLVQKMKKISRLHMQECTINGGNNSYQSLQNKDSDVNGFLKMIEEMIRSSSLYDE
Protein: Intermembrane phospholipid transport system permease protein MlaE (Q9HVW2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU362044}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU362044}.
Interaction partners:
- Intermembrane phospholipid transport system ATP-binding protein MlaF
- Mce/MlaD domain-containing protein
- STAS domain-containing protein
- Toluene tolerance protein
- Probable ATP-binding component of ABC transporter
- Mce/MlaD domain-containing protein
- Probable permease of ABC transporter
- DUF7380 domain-containing protein
- GTP 3',8-cyclase 2
- Probable transcriptional regulator
Sequence:
MRRVSPLERIRLFGRAGLDVVAALGRSTLFLGHALLGRRTPGTGLHLLVKQLYSVGVLSLAIIVVSGLFIGMVLALQGYNILISYGSEQAVGQMVALTLLRELGPVVTGLLFAGRAGSALTAEIGNMKATEQLSSLEMIGVDPLKYIVAPRLWAGFISMPLLAAIFSVVGIWGGAMVAVDWLGVYEGSFWANMQNSVQFTEDVLNGVIKSIVFAFVVTWIAVYQGYDCEPTSEGISRATTRTVVYASLAVLGLDFILTALMFGDF
Protein: Telomere length regulation protein conserved domain-containing protein (Q57VF5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQAANISEESIYNEARYSLSKLKNSCRDILGTSRVTPPVEVVQQFLDFLGVDILPDVFSVEIETESLTLCTSAPLVMVLAELSTDCGDDEISLVRKQVLRTRCTFIASLPERLANIICELQAVGKDVDCDWGVLPDRICQALCCFLFAICTASSDQEPTIPNEGKTYELKRSSALAVCDFMIQAVLARGYIGMLFRHFLISLRSATNISTMSNLTFPFVLTSIYNCAFTSRGKSELLEATSTPKRYRATVYWTEWVSWLLEASASEPKTKKCLISTLLLMREGQDDPVMAGKSSHVGQALEVEIFATSAFYLPTRRDVLRVIFREVLPTISFRGDGDKPGHIQNFELTLFAEVFRVWGDRNFAESAPIRLNTTLSNSVMYILLHIKENGIFCERSHFPSALLQPLLDGISLRLESVRSEETRNEGITVAAAFALFFSSEDDTLNGVSDLELFPEALSKWMRHEPNHALMPGLSHEGITERTHRVAGEDRAKFFRHSAENDEYPLDPDAEFTFFCAGDTSKSNVLVSSGTDNALFKHIPIANNEELTSFGKTSHEADSLDGIDVLVTLRESYNAVMGIGRSTSAQLYEVQQETESGLRGLKSSLQVLKGKLGRWNERVIDGNVLRTRSTLGEELHVMLPSLLPALMSITIHAPEPRHKELVELRLSVLIDIIIVSPEVALDQLSKMIYSSGFGIFQRVEMAKAIGEAAKFLSHVKIRVEYEGKLKQYNDTQFRDPQKRIYPPIPNESKSITSTVFTEGRNTRRWGNSTRRRACQEENVYTSYLSEVAPLFISALLQKADDDYFSFFRDKDPYAPAEILRTISTVVQRIAAVRHVAPSLCENIVPFILAVLTRHPLSVIRKQAWILIGEVMRCWCGAGPLVLDDCSSTTCREGFGGSSSHLFSEQWINVQQALEAIFDRSRNDFLCAEVALLVVVDLRDLLVARADFEEMNKRVVSARLISAVE
Protein: UPF0540 protein At1g62080 (O04575)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MNATKFLVLLVIGVLCAIVTARQVKDLSTETKLGASLPKTTTKGIGAQLSATGSTFSSSSVVSYANGFNNPKGPGANAFESGSTFTSGQVTAKGRKARVSSASASTATGEAAAAVTRKAAAARAKGKVASASRVKGSSEKKKKDRKGKKD
Protein: Isocitrate dehydrogenase [NAD] regulatory subunit B, mitochondrial (EC 1.1.1.41) (Q54B68)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Performs an essential role in the oxidative function of the citric acid cycle.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Probable aconitate hydratase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- Probable cytoplasmic aconitate hydratase
- Isocitrate dehydrogenase, mitochondrial
- hydroxymethylglutaryl-CoA lyase
- Isocitrate dehydrogenase regulatory subunit A, mitochondrial
- Glutamate dehydrogenase, mitochondrial
- Glutamate dehydrogenase 2
- Bifunctional protein argC
Sequence:
MLGRLRTVVKASSSNSIRNYLGYTSGVQKKTVTVIPGDGIGPEITSSVMGVFQAAKVPIEWEIFDISGGQPISQELIASITRNKVALKGPLYTEILSGSQSRNMELRKALDLYAHVVPCKQIPGITARHDDVLVDFVVIRENTQGEYSGLEQVLTPGVVQSLKIITKEASERIARYAFEYAKANGRKKVTAVHKANIQKQTDGLFLATCTQIAKEYPEIKFENTIIDNCCMQLVKSPEQYDVMVTPNLYGNIVSNIGAALVGGPGLAGGANVGEGSIIFEMGAHHVAADIAGKDKANPTGLLLASVMMLKHLGLNEHATKVENAVKAVIKEGTLTSDIGGKSSTKQFTGAVIDYIEKNQN
Protein: Calcium-transporting ATPase (EC 7.2.2.10) (Q642Z0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|RuleBase:RU361146}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}. Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004326}.
Interaction partners:
Sequence:
MENAHTKETPECLAYFGVSESTGLTPEQVKKNQAKYGFNELPAEEGKSIWELVVEQFEDLLVRILLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVYRSDRKSVQRIKAREIVPGDIVEVSVGDKVPADIRITAIRSTTLRVDQSILTGESVSVIKHTESVPDPRAVNQDKKNMLFSGTNIAAGKAIGVVVATGVSTEIGKIRDQMAATEQEKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMCVTKMFVIEKVEGESVTLDQYDISGSKYTPEGEVTKNGLPVKCGQFDGLVELATICALCNDSSLDYNESKGIYEKVGEATETALCCLVEKMNVFNTDVRGLSKVERANTCCAVIKQLMKKDFTLEFSRDRKSMSVYCSPAKASKAPVGNKMFVKGAPEGVIDRCAYVRVGTTRVPLTGPVKDKIMAVIKEWGTGRDTLRCLALATRDNPLRPEEMNLEDSTKFAEYETDLTFVGCVGMLDPPRKEVVGSIELCRAAGIRVIMITGDNKGTAVAICRRIGIFSDDEDVTGRAFTGREFDDLPLPQQREAVRKACCYARVEPSHKSKIVEFLQGFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSASEMVLADDNFSSIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMGKAPRSPKEPLISGWLFFRYLAIGGYVGAATVAAAGWWFLYCDEGPMVSFYQLSHFMQCTADNEDFAGIECEVFEAAPPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWSNLWLAGAMTLSMSLHFMIIYVDPLPMIFKLTHLNFDQWIVVLKLSFPVILIDEALKFVARNYLEA
Protein: Mitochondrial ribosomal protein S27 (G5EA06)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MDKTFERKLPVSSLTISRLIDNISSREEIDHAEYYLYKFRHSPNCWYLRNWTIHTWIRQCLKYDAQDKALYTLVNKVQYGIFPDNFTFNLLMDSFIKKENYKDALSVVFEVMMQEAFEVPSTQLLSLYVLFHCLAKKTDFSWEEERNFGASLLLPGLKQKNSVGFSSQLYGYALLGKVELQQGLRAVYHNMPLIWKPGYLDRALQVMEKVAASPEDIKLCREALDVLGAVLKALTSADGASEEQSQNDEDNQGSEKLVEQLDIEETEQSKLPQYLERFKALHSKLQALGKIESEGLLSLTTQLVKEKLSTCEAEDIATYEQNLQQWHLDLVQLIQREQQQREQAKQEYQAQKAAKASA
Protein: Heat shock 70kDa protein 8 isoform 2 variant (Q53HF2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVTTVLIKRNTTIPIKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
Protein: Martik, isoform A (Martik, isoform B) (Martik, isoform C) (Martik, isoform D) (Martik, isoform E) (Martik, isoform F) (Q9VB49)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLMPRYLDSSTSSGSHGAAGATNSSSSPPTTVAAHTKMRLLSKVEHNMRQSQGHIQSNQSNASGQDINHLLHTASTGNGVVDDVDGLLTPMRIKAHMSPPYSAGSSVKSDSLGYSPRPERNLWSRAEMLEMLSIMQNLNALEQLNDRNMKSEQVFRQIEEVMRSKGFVKKSSIQIWTKWKFLKSTYNTTTRHGTGVPKVVPEEVYRVLCRMLSDTNHGGGNSNVNGSLSECGNSMDSSKTAGDDNKEDILGVEHPIFGFRLGPIKPEPIDIGYETTEKHDMVSEPDMESFDYEAGSSHADNGDQEDVPHLPFIVSVKHEPDVDLGMDTTNTPPPTAPASPSPPPVTVDDTEDDSVYSSTPVAPPPLRVASFAKGELRRPTHGILQIDRPPPTLTKMGQQQIPNPGQMSRSVPLQSTSSINFVHPHSKLMLPRRQNPNSSQSGLRLPRDISVQSTGMRMKTVPMRDTGYSLRPDRMTHDIDQSTSSPPQSPSTMSSLLGRGPPPKYQIAGQQAGASTSRQAHMMSSHQLTPVQHQQLQPRKRRLGQSPVMGMPVPVKLQRSSNMYGSAPKDIRSHPAVGEESKKKSSEEETKQRRKRQDELLAKELSQLASAMRTAQKEMLQDFFLQQKEIARREHVFQMKQDSLVMRTLRRQTDALLRTANELVSGVSEAAKMEPDDKEGVIPETQMPFEPETELQTPESEEDNENGEGYAGDDVQETMEEPDYEDNEDDDYEHDEDEEDEGDYDENMANDSDLEMSNLAMSEGSNNAEIISGGH
Protein: CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (CCR4-associated factor 1) (CAF-1) (Q08BM8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex subunit 6-like
- CCR4-NOT transcription complex subunit 2
- CCR4-NOT transcription complex subunit 9
- poly
- CCR4-NOT transcription complex subunit 10
- CCR4-NOT transcription complex subunit 11
- CCR4-NOT transcription complex subunit 3
- m7GpppN-mRNA hydrolase
- CCR4-NOT transcription complex subunit 3
Sequence:
MPAATVDHSQRICEVWACNLEEEMKRIRQVTRKFNYIAMDTEFPGVVARPIGEFRSNADYQYQLLRCNVDLLKIIQLGLTFMNEQGEYPPGTSTWQFNFKFNLTEDMYAQDSIELLTSSGIQFKKHEEEGIETMYFAELLMTSGVVLCEGVKWLSFHSGYDFGYLIKILSNSKLPDEEVDFFEILRLFFPIIYDVKYLMKSCKNLKGGLQEVAEQLELERIGPQHQAGSDSLLTGMAFFKMREMFFEDHIDDAKYCGHLYGLGSGSSYVQNGTGNAYEEEANKQQS
Protein: Protein MENT (Methylated in normal thymocytes protein) (Q9BUN1)
Organism: Homo sapiens (Human)
Function: Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MVPAAGALLWVLLLNLGPRAAGAQGLTQTPTEMQRVSLRFGGPMTRSYRSTARTGLPRKTRIILEDENDAMADADRLAGPAAAELLAATVSTGFSRSSAINEEDGSSEEGVVINAGKDSTSRELPSATPNTAGSSSTRFIANSQEPEIRLTSSLPRSPGRSTEDLPGSQATLSQWSTPGSTPSRWPSPSPTAMPSPEDLRLVLMPWGPWHCHCKSGTMSRSRSGKLHGLSGRLRVGALSQLRTEHKPCTYQQCPCNRLREECPLDTSLCTDTNCASQSTTSTRTTTTPFPTIHLRSSPSLPPASPCPALAFWKRVRIGLEDIWNSLSSVFTEMQPIDRNQR
Protein: Transcriptional regulator WhiB4 (P9WF39)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Redox-responsive transcriptional regulator that regulates a set of genes involved in protection against environmental stresses encountered during infection. The loss of the O(2) and NO-responsive 4Fe-4S cluster and subsequent redox modifications of Cys residue thiols (possibly by disulfide bond formation) may activate its role in gene regulation. The thiol-oxidized apo-form binds in a sequence non-specific manner to GC-rich DNA, probably in the minor groove. Represses transcription of a number of genes including itself. The reduced apo-form and holo-form do not bind DNA. The apo-form can act as protein disulfide reductase.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Probable cell division protein WhiA
- Adenine phosphoribosyltransferase
- Uncharacterized HTH-type transcriptional regulator Rv1830
- Probable protein-export membrane protein SecG
- Uncharacterized protein Rv2901c
- DNA-directed RNA polymerase subunit omega
Sequence:
MSGTRPAARRTNLTAAQNVVRSVDAEERIAWVSKALCRTTDPDELFVRGAAQRKAAVICRHCPVMQECAADALDNKVEFGVWGGMTERQRRALLKQHPEVVSWSDYLEKRKRRTGTAG
Protein: Keratin-associated protein 3-3 (High sulfur keratin-associated protein 3.3) (Keratin-associated protein 3.3) (Q9BYR6)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin, type II cuticular Hb3
Sequence:
MDCCASRGCSVPTGPATTICSSDKSCRCGVCLPSTCPHTVWLLEPTCCDNCPPPCHIPQPCVPTCFLLNSCQPTPGLETLNLTTFTQPCCEPCLPRGC
Protein: Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphoinositide-3-kinase class 3) (O88763)
Organism: Rattus norvegicus (Rat)
Function: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes.
Subcellular location: Midbody {ECO:0000250|UniProtKB:Q8NEB9}. Late endosome {ECO:0000250|UniProtKB:Q8NEB9}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8NEB9}. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (By similarity). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q6PF93, ECO:0000250|UniProtKB:Q8NEB9}.
Interaction partners:
- Nuclear receptor-binding factor 2
- UV radiation resistance associated
- Phosphoinositide 3-kinase regulatory subunit 4
- Beclin-1
- Beclin 1-associated autophagy-related key regulator
- Activating molecule in BECN1-regulated autophagy protein 1
- Autophagy related 13
- non-specific serine/threonine protein kinase
- RB1-inducible coiled-coil protein 1
- Gamma-aminobutyric acid receptor-associated protein
Sequence:
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKPFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGRAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQASVSESLSSSGVSSADIDSSQIITNPLPPVASPPPASKSKEVSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
Protein: Hexosyltransferase (EC 2.4.1.-) (Q57Y33)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}.
Interaction partners:
Sequence:
MCRQFNSRGRILRSSISLTVLLFTICVVTSLLTTLSNNSERAGKREINVPKTAIANKGQHLSEHPLWVKQSLTYVPAPVVSAWEERRYLVVIGIPSIDLDVRRRRRDLQRAACWTYAGVAVRANGFSGEMLPLYILARHPENGYTYTKALVEEATQWSDILTLPMNEGRPSGRKRVGQGGKWGIDAEIGMSRKTFLWFDMSVCLFPYAPYIAKADDDMFLRVPQYLADLRNLPRRGLYWGTIDVLSVQGFRFNYAYGACYTLGRDVAERFVSYKPLRTIIHVPYTAIRDEEFQSLCVMVEDAMVGITLRRAMYHTNITYVHEPKCSFHDVHAGTTLGAVTKSSIMVHHVNESDYNELRRRFNNEKNTSHRSLTGSQGPLREMSCL
Protein: Zinc finger FYVE domain-containing protein (A8Y5G5)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR037289}. Early endosome membrane {ECO:0000256|PIRNR:PIRNR037289}.
Interaction partners:
Sequence:
MENYFQAEAYNLDKVLDEFEQNEDETVSPTLLDTKWNKILDPSSHPLSFNPALASVNEPTVSETGPQLKVFSLAGSAPLTKEDKDPCANGQDCSLNPETDTMWIDENAVTEDQLIKRNYNQDDQFSAVEVGEEKCGSLTCLPDEKNVLVVAVMHNCDKRTLQSDLQDCNNYNSQSLMNSFSCSLDNETRQTDQFSFSMNGSTEKGINSEKQMDALNKPKPERDSVNHLCAASSNSATSISSPSQLKDGENVGRDPSTSTVTSLAVNSSQGMDGGPAIKQQGNYMPDEDLSGMNSSSRTDLGISNSFSHSSGELLIKTEPAEERTAEDSLPSDLSLNLKPDTPALSGRDNCEQSSDCLGSSETRADEDEGNDSQMTNWKLTKLNEMSDSQVNEENQMALQSNQPEDTNSGGECVGMADSDLDFKGTCMNESEGYDFSTVNDAPAANSLSNSCDSYGMQSPIVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNENAEGSGLLLNSTGNVMKKNYLHNFCSQIPSVLGQSSPKIANLQSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDLPANNGNNSKNKNDVLGKAKLGENSAVNACSATLGNISVTDTNGEHLETYEAEISSRPCLALAPDSPDNDLRASQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNVPQPREQRRVWFADGILPNGEVADAAKLTMNGTSSAGTLAVSHDPVKPVATSPLPTEADTSLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVGSLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLLLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEDPQEQIHIQWVDDDKTVNKGVVSPIDGKSMESITNVKIFHGSEYKANGKVIRWTEVFFLENDDHHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILENIA
Protein: Polygalacturonase ADPG1 (AtADPG1) (PG ADPG1) (EC 3.2.1.15) (Pectinase ADPG1) (Protein ARABIDOPSIS DEHISCENCE ZONE POLYGALACTURONASE 1) (O23147)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Polygalacturonase involved in cell separation in the final stages of pod shatter and in anther dehiscence. Not involved in floral organ abscission.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:11485203}. Cytoplasm {ECO:0000269|PubMed:11485203}. Note=Released to the cell wall during maturation of the dehiscence zone.
Interaction partners:
- Polygalacturonase 1 beta-like protein 2
- At1g64405
- GDSL esterase/lipase At1g58430
- Pectinesterase QRT1
- Probable pectinesterase/pectinesterase inhibitor 17
- Exopolygalacturonase clone GBGA483
- Pectin lyase-like superfamily protein
- Pectin lyase-like superfamily protein
- Mannan endo-1,4-beta-mannosidase 7
- Exopolygalacturonase clone GBGE184
Sequence:
MARCCRHLAVFLCVLLMLSLCKALSSNVDDGYGHEDGSFESDSLLKLNNDDVLSLISSDETTLEASTVSVSNFGAKGDGKTDDTQAFKKAWKKACSTNGVTTFLVPKGKTYLLKSTRFRGPCKSLRNFQILGTLSASTKRSDYKDKNHWLILEDVNNLSIDGGSTGIINGNGKTWWQNSCKIDKSKPCTKAPTALTLYNLKNLNVKNLRVKNAQQIQISIEKCNKVEVSNVEITAPGDSPNTDGIHITNTQNIRVSNSDIGTGDDCISIEDGTQNLQIFDLTCGPGHGISIGSLGDDNSKAYVSGINVDGAKFSESDNGVRIKTYQGGSGTAKNIKFQNIRMENVKNPIIIDQDYCDKDKCEDQESAVQVKNVVYKNISGTSATDVAITLNCSEKYPCQGIVLENVKIKGGTASCKNANVKNQGTVSPKCS