wanglab/gogpt-training-data huggingface dataset:
Protein: Protein starmaker (A2VD23)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration. May be one of the organic components of the ortholiths.
Subcellular location: Secreted {ECO:0000269|PubMed:14551434}. Note=Detected on otoliths and the apical surface of epithelial cells in the otic placode in larvae 24 hours after fertilization.
Interaction partners:
- Notchless protein homolog 1
- Ribosome biogenesis protein wdr12
- Otolith matrix protein 1
- Si:dkey-92i15.4.
- Nucleolar GTP-binding protein 2
- Zona pellucida-like domain-containing 1a.
- Protein SDA1 homolog
- Si:dkey-205h13.2.
- Testis-expressed protein 10 homolog
- Small subunit processome component 20 homolog
Sequence:
MLSRTVFVPLILAFVGVSISAPVSNNNGTDNDESAADQRHIFTVQFNVGTPAPADGDSVTTDGKDSAEKNEAPGDSSDTTEKPGTTDGKDSAEQHGVTTDGKDEAEQHGVTTDGQDSAEKRGEADGAPDKPDTQNGTDDTDSDQETDASHHKTGDSDENKDKPSAEDHTDGNHAGKDSTDSKESPDTTDKPEGPDSDSAPDGDSASAEKTDSDHSPDEDANKSSTEADKDDTSDKDSSQTDEKHDSDASDKDEKHEDKDEKSDEKDSSKDSEDKSQEKSDKSDDGSNSEADEQKESVESKDHDSDSQDSDSAEKKEKHDDKDQDSSDSADSKDSDEDKDKDHSEQKDSEDHEHKEKHTKDKEEHKDSDEGKDDEDKSKSDEHDKDESESKEASKSDESEQEEKKDDKSDSDNSSRDSHSDSDSDSHSDSDSDSHSDSHSDSDSDSHSDSDSDSDSDSDSDSDSDSDSNSRDKDEKKDKSSESRDEDSSDSDSKSNSESSETAEEDTNDDKDSSVEKDKTDSSDSASVEANDSDDEHDDDSKDATPSSEDHTAEKTDEDSHDVSDDDDDIDAHDDEAGVEHGTDEASKPHQEPDHHDDTTHGSDDGRKTSMPIS
Protein: Shaven, isoform D (Q59DP0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLIMDIQTSTHHIHGLGTHELQHRILHPHILHSTQEETLNTSTGQLEHDSQHLQQHHLTHHQQQDVSPTLHNLQNTRTGDSLSTTINTNQNQHGHQHLSGSNMYTSSQMEDKSKANKYDEYSSRTLSNISDANTTPSANNFITQSQGIEWITAMNDIQNGAEDSHSSQGSISGDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSINRIVRNKAAEKAKHVHHHQQHHVSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSANSVNTNVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGIQHGHHSHNNNNNSSVNNNNNTESSCKRKRIEAHDENHDTNIHSDNDDGKRQRMSTYSGDQLYTNIWSGKWCIKDDHKLLAELGNLTASTGNCPATYYEASNGFSTTPISGSGATASGNDTSMLYDSITTISQTQSSIYTPAIGPSIGTGSLTPLVPISMHEMKLSANSIQEQTVPPFYTGCSSVVPGSDYAYNPAYTQYGGAYGSYGYGTGSGLINSSYYYESGQTQSPLTHDLRSPLVATRANSLASAASPGSGSACTKSESSDIFLA
Protein: Serine/threonine-protein kinase BSK5 (EC 2.7.11.1) (Brassinosteroid-signaling kinase 5) (Q9FIL1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Involved in abiotic stress tolerance. Required for salt stress and abscisic acid-mediated drought stress tolerance.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22982312}; Lipid-anchor {ECO:0000305|PubMed:12912986}.
Interaction partners:
- Shaggy-related protein kinase eta
- Shaggy-related protein kinase iota
- Putative acyl-activating enzyme 19
- Protein BRASSINAZOLE-RESISTANT 2
- Serine/threonine-protein phosphatase BSU1
- Serine carboxypeptidase 24
Sequence:
MGPRCSKLSLCWWPTHLKSTHNEASDLDNGTDDLPSFTEFSFDQLRAATCGFSTDSIVSEHGVKAPNVVYKGRLEDDRWIAVKRFNRSAWPDTRQFLEEAKAVGQLRNERLANLIGFCCEGDERLLVAEFMPFETLSKHLFHWDSQPMKWSMRLRVALYLAQALEYCSSKGRALYHDLNAYRILFDQDGNPRLSCFGLMKNSRDGKSYSTNLAFTPPEYLRTGRVIPESVVYSFGTLLLDLLSGKHIPPSHALDLIRGKNFLMLMDSCLDGHFSNDDGTDLVRLASRCLQYEARERPNVKSLVSSLAPLQKETDIPSHVLMGIPHGAASPKETTSLTPLGDACSRHDLTAIHEILEKVGYKDDEGVANELSFQVWTDQIQETLNSKKQGDAAFKGKDFVTAVECYTQFIEDGTMVSPTVFARRCLCYLMSNMPQEALGDAMQAQVVSPEWPTAFYLQAAALFSLGMDKDACETLKDGTSLEAKKHNNRN
Protein: Caveolae-associated protein 1 (Cav-p60) (Cavin-1) (Polymerase I and transcript release factor) (O54724)
Organism: Mus musculus (Mouse)
Function: Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template. The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A.
Subcellular location: Membrane, caveola {ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19546242, ECO:0000269|PubMed:25514038}. Cell membrane {ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225}. Microsome {ECO:0000250|UniProtKB:Q6NZI2}. Endoplasmic reticulum {ECO:0000269|PubMed:30188967}. Cytoplasm, cytosol {ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19546242}. Mitochondrion {ECO:0000250|UniProtKB:Q6NZI2}. Nucleus {ECO:0000269|PubMed:25514038, ECO:0000269|PubMed:27528195}. Note=Translocates to the cytoplasm from caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes (PubMed:18056712). Localizes in the caveolae in a caveolin-dependent manner (PubMed:19546242). {ECO:0000250|UniProtKB:Q6NZI2, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:19546242}.
Interaction partners:
- Caveolin-1
- Caveolin-3
- EH domain-containing protein 2
- Caveolin-2
- Tripartite motif-containing protein 72
- Dysferlin
- EH domain-containing protein 3
- Protein kinase C and casein kinase substrate in neurons protein 2
- Caveolae-associated protein 3
- Transcription termination factor 1
Sequence:
MEDVTLHIVERPYSGFPDASSEGPEPTQGEARATEEPSGTGSDELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSVSKSLKESEALPEKEGDELGEGERPEDDTAAIELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPVERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGEVEVLKATEMVEVGPEDDEVGAERGEATDLLRGSSPDVHTLLEITEESDAVLVDKSDSD
Protein: Glutathione synthetase (EC 6.3.2.3) (GSH synthetase) (GSH-S) (GSHase) (Glutathione synthase) (P04425)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Glutamate--cysteine ligase
- Glutathione reductase
- Cytosol non-specific dipeptidase
- Glutathione hydrolase proenzyme
- Cytosol aminopeptidase
- Bifunctional glutathionylspermidine synthetase/amidase
- Thioredoxin/glutathione peroxidase BtuE
- Glutathione S-transferase YfcF
- Putative glutamate--cysteine ligase 2
- Glutathione S-transferase GstA
Sequence:
MIKLGIVMDPIANINIKKDSSFAMLLEAQRRGYELHYMEMGDLYLINGEARAHTRTLNVKQNYEEWFSFVGEQDLPLADLDVILMRKDPPFDTEFIYATYILERAEEKGTLIVNKPQSLRDCNEKLFTAWFSDLTPETLVTRNKAQLKAFWEKHSDIILKPLDGMGGASIFRVKEGDPNLGVIAETLTEHGTRYCMAQNYLPAIKDGDKRVLVVDGEPVPYCLARIPQGGETRGNLAAGGRGEPRPLTESDWKIARQIGPTLKEKGLIFVGLDIIGDRLTEINVTSPTCIREIEAEFPVSITGMLMDAIEARLQQQ
Protein: Sulfite reductase [NADPH] flavoprotein component (EC 1.8.1.2) (P39692)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Interaction partners:
- Sulfite reductase subunit beta
- Uroporphyrinogen-III C-methyltransferase
- Phosphoadenosine phosphosulfate reductase
- Adenylyl-sulfate kinase
- Sulfate adenylyltransferase
- Homocysteine/cysteine synthase
- Putative mitochondrial cysteine synthase
- Cystathionine gamma-synthase
- Thiosulfate sulfurtransferase TUM1
- Homocysteine/cysteine synthase
Sequence:
MPVEFATNPFGEAKNATSLPKYGTPVTAISSVLFNNVDSIFAYKSFSQPDLLHQDLKKWSEKRGNESRGKPFFQELDIRSGAGLAPLGFSHGLKNTTAIVAPGFSLPYFINSLKTVSHDGKFLLNVGALNYDNATGSVTNDYVTALDAASKLKYGVVTPISANEVQSVALLALAIATFSNNSGAINLFDGLNYSKTVLPLVESVPEASILAKLSKVIAPDAAFDDVLDKFNELTGLRLHNFQYFGAQDAETVFITYGSLESELFNSAISGNNSKIGLINVRVPLPFNVAKFVTHVPSTTKQIVVIGQTLDGSSPSFLRSQVSAALFYHGRTSISVSEYIYQPDFIWSPKAVKSIVSSFIPEFTYNADSSFGEGFIYWASDKSINIDVASKLVKALSLEDGKFVSLRTKFDNLANAGTFQAQFVTSKEQIPVSNIDSTKLSVVEDVSLLKHLDVAATVAEQGSIALVSQKAVKDLDLNSVESYVKNLGIPESFLISIAKKNIKLFIIDGETTNDESKLSLFIQAVFWKLAFGLDVAECTNRIWKSIDSGADISAASISEFLTGAFKNFLSEVPLALYTKFSEINIEKKEDEEEPAALPIFVNETSFLPNNSTIEEIPLPETSEISDIAKKLSFKEAYEVENKLRPDLPVKNFVVKVKENRRVTPADYDRYIFHIEFDISGTGMTYDIGEALGIHARNNESLVKEFLTFYGLNESDVVLVPNKDNHHLLETRTVLQAFVENLDIFGKPPKRFYESLIPYASNEEEKKKLEDLVTPAGAVDLKRFQDVEYYTYADIFELFPSVRPSLEELVTIIEPLKRREYSIASSQKVHPNEVHLLIVVVDWVDNKGRKRYGQASKYISDLAVGSELVVSVKPSVMKLPPSPKQPVIMSGLGTGLAPFKAIVEEKLWQKQQGYEIGEVFLYLGSRHKREEYLYGELWEAYKDAGIITHIGAAFSRDQPQKIYIQDRIKENLDELKTAMIDNKGSFYLCGPTWPVPDITQALQDILAKDAEERGIKVDLDAAIEELKEASRYILEVY
Protein: Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) (Vitellogenin receptor) (VTG receptor) (P98165)
Organism: Gallus gallus (Chicken)
Function: Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.
Interaction partners:
- Reelin
- DAB1, reelin adaptor protein
- Proprotein convertase subtilisin/kexin type 9
- Apolipoprotein B
- SH3 domain-containing kinase-binding protein 1
- Vitellogenin-1
- Vitellogenin-2
- Lipoprotein lipase
- Apovitellenin-1
Sequence:
MRSSRQRGDRSAATGGGCGARRWALPRCGALCLLLALGCLRTATDGAKAKCEESQFQCSNGRCIPLLWKCDGDEDCSDGSDESACVKKTCAESDFVCNSGQCVPNRWQCDGDPDCEDGSDESAELCHMRTCRVNEISCGPQSTQCIPVSWKCDGEKDCDSGEDEENCGNVTCSAAEFTCSSGQCISKSFVCNGQDDCSDGSDELECAPPTCGVHEFQCKSSTCIPISWVCDDDADCSDHSDESLEQCGRQPAPPVKCSTSEVQCGSGECIHKKWRCDGDPDCKDGSDEINCPSRTCRPDQFRCEDGNCIHGSRQCNGVRDCLDGTDEANCNNVIQCSGPGKFKCRSGECIDINKVCNHHGDCKDWSDEPLKECNINECLVNNGGCSHICRDLVIGYECDCPAGFELVDRRTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPCLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAEQKLYWADFSQKAIFSASIDTRDKVGTHTRILDNIHSPAGIAVDWIYKNIYWTDSSAKTISVASLNGKKRKVLFLSELREPASIAVDPLSGFMYWSDWGEPAKIEKAGMNGFDRQQLVTTEIQWPNGIALDLVKSRLYWLDSKLHMLSSVDLNGQDRRLVLKSHMFLPHPLALTIFEDRVFWIDGENEAVYGANKFTGAELVTLVNNLNDAQDIIVYHELVQPSGRNWCEENMVNGGCSYLCLPAPQINEHSPKYTCTCPAGYFLQEDGLRCGGFNISSVVSEVAARGAAGAWAVLPILLLVTAALAGYFMWRNWQHKNMKSMNFDNPVYLKTTEEDLTIDIGRHSGSVGHTYPAISVVSTDDDML
Protein: RRM domain-containing protein (H2L051)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MYGQVQDPLVHAAAAALAQSTNAEPVVGSRDTMFTKIFVGGLPYHTSDKTLHEYFEQFGDIEEAVVITDRNTQKSRGYGFVTMKDRASAERACKDPNPIIDGRKANVNLAYLGAKPRTNVQLAALAAGQVQLPLTTQLQALFQPRMGQVAG
Protein: Vicilin-like seed storage protein At3g22640 (Globulin At3g22640) (Q9LUJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Seed storage protein.
Interaction partners:
- Glycine-rich protein
- Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 8
- Oleosin family protein
- Late embryogenesis abundant protein M17
- Pollen Ole e 1 allergen and extensin family protein
- Serine carboxypeptidase-like 20
Sequence:
MAITNKLIITLLLLISIAVVHCLSFRVEIDEFEPPQQGEQEGPRRRPGGGSGEGWEEESTNHPYHFRKRSFSDWFQSKEGFVRVLPKFTKHAPALFRGIENYRFSLVEMEPTTFFVPHHLDADAVFIVLQGKGVIEFVTDKTKESFHITKGDVVRIPSGVTNFITNTNQTVPLRLAQITVPVNNPGNYKDYFPAASQFQQSYFNGFTKEVLSTSFNVPEELLGRLVTRSKEIGQGIIRRISPDQIKELAEHATSPSNKHKAKKEKEEDKDLRTLWTPFNLFAIDPIYSNDFGHFHEAHPKNYNQLQDLHIAAAWANMTQGSLFLPHFNSKTTFVTFVENGCARFEMATPYKFQRGQQQWPGQGQEEEEDMSENVHKVVSRVCKGEVFIVPAGHPFTILSQDQDFIAVGFGIYATNSKRTFLAGEENLLSNLNPAATRVTFGVGSKVAEKLFTSQNYSYFAPTSRSQQQIPEKHKPSFQSILDFAGF
Protein: Muscleblind-like protein 2 (Q8C181)
Organism: Mus musculus (Mouse)
Function: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q5VZF2}. Cytoplasm {ECO:0000250|UniProtKB:Q5VZF2}. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques. Location in the cytoplasm is microtubule-dependent. {ECO:0000250|UniProtKB:Q5VZF2}.
Interaction partners:
- KH domain-containing RNA-binding protein QKI
- CUGBP Elav-like family member 1
- Chloride channel protein 1
- Myotonin-protein kinase
- CCHC-type zinc finger nucleic acid binding protein
- CUGBP Elav-like family member 2
Sequence:
MALNVAPVRDTKWLTLEVCRQYQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHPVPTFPVGPTIGTNAAISFAPYLAPVTPGVGLVPTEVLPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMTQSTAKALKRPLEATVDLAFPPGALHPLPKRQALEKSNGASTVFNPSVLHYQQALTSAQLQQHTAFIPTVPMMHSATSATVSAATTPATSVPFAATATANQIILK
Protein: Protein PET130 (P47065)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion matrix {ECO:0000305}.
Interaction partners:
- Required for respiratory growth protein 8
- Protein YPR117W
- Ribonuclease P protein component, mitochondrial
- Genetic interactor of prohibitin 5, mitochondrial
- Increased recombination centers protein 19
- Required for respiratory growth protein 1
- Uncharacterized protein YOR304C-A
Sequence:
MKIFSTLLSQKPKGKLVIRPSTTIHSSDPFSKFIVTKNTEPLSLGDLRKSDSGNSAVCLNAENTILSTLTDLQKEEERNWDPVKFVAGKLRGVISPIQAYVTIGKKFSPNSLVYTSRFFQLHYFPEDHFMSCFRKSKPAITVKSNKKFYLNGKVFNKDKEYFNETRISKANEVELSKIQTAMTRLTNRHRNSIPSEFAYLRRDLKLKVKTTFIKEWCKLNGDKAIREYVNLNRSPNINPASMKGKPKKSFLDNLGRSTVGTAKDGYYLYIVSIFPDKDMLGEFNDEVNRSVQKVANLDWDGFLTPKKGTKGKNWVESFNDSINVQTINKILEINKFPFELRREQTEG
Protein: Killer cell lectin-like receptor subfamily C, member 2 (Q8CB89)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MSHLLGTEQASEPRKATKKTQAQFRFSNAAGDRLLEFSLQHASQKHLKASRHGYCKNFASPPEKLIAGILGTIWFTLLIALVISTRIVSPYAELKKQIHPFLVRTQKGSHALLSKAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLGSCLSKNCSLLHIDSEEEQDFLQSLSLVSWTGILRKGRGQAWDWKKDSIFKPKSLAPFR
Protein: Hypoxia-inducible factor 1-alpha (D0VY79)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
Protein: DUF866 domain-containing protein (Q4GYN4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPLYRLSVSAETEGVVCIRPMRPRNWGLKVTCDACREFSPNFVYVDESEECDSGGGGTRNAAFKCASCKTLITAHIDPESYGTYRPEEDNGKGDGNSILIIEVRGATPTELEIDDKWVVEAEGATFEAADLSTDWMEYDEKSGNAVSVSQFTVEFSRLKKSK
Protein: Uncharacterized protein (Q9VLB0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- MIP13722p
- IP19013p
- GEO10373p1
- Mucin 4B, isoform B
- RE05851p
- Femcoat
- Uncharacterized protein, isoform B
- Kazal-like domain-containing protein
- FI16876p1
- Uncharacterized protein
Sequence:
MHPWSISAKMVGCPETRQLLVTLLLTLGFCLGGSSKDTVADADAKWMAPLKQYGYTPQHLKNKVEHGEFTTFELGTPNYQILNPEDEPEYITADQPHYQEMLRRLTSGRSKADTIDVEMASRTETVRETSDPGQSKKPSQIQVPVKPKTQLKQNRWEKLRKRSSIEKRRDHKETMETDVRDDQSFFPDIQVYPGLPFQSRVANLN
Protein: SD22389p (Q8MSQ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSALESIVRENPERLTRFLHELQKVTRFLHQLCCHSKSIKNTAIISYIPSLRETIETLVFRVKALLAANNCHSAFHMGNMINRDLHGDSIITPRSSFAGEENSDDELPADDTSVDETVLGDDMGITAVSVSTRPSDGSRRSKSSSRSKCF
Protein: Cadherin 5 (I3L1J2)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIG
Protein: Uncharacterized protein YqjD (P64581)
Organism: Escherichia coli (strain K12)
Function: Upon overexpression inhibits growth.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:22380631, ECO:0000269|PubMed:22661687}; Single-pass membrane protein {ECO:0000269|PubMed:22380631, ECO:0000269|PubMed:22661687}. Note=Predominantly localized to 1 cell pole in stationary phase, with a few smaller foci elsewhere in the cell; polar localization depends on the minCDE operon.
Interaction partners:
- Protein YqjC
- Protein ElaB
- Inner membrane protein YqjE
- Uncharacterized protein YqjK
- Uncharacterized protein YgaM
- Osmotically-inducible protein Y
- Uncharacterized protein YccJ
- DNA protection during starvation protein
- NAD
- Serine/threonine kinase YeaG
Sequence:
MSKEHTTEHLRAELKSLSDTLEEVLSSSGEKSKEELSKIRSKAEQALKQSRYRLGETGDAIAKQTRVAAARADEYVRENPWTGVGIGAAIGVVLGVLLSRR
Protein: Putative cytochrome P450 139 (EC 1.14.-.-) (P9WPM1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Polyketide synthase Pks13
- Beta-dihydromenaquinone-9 omega-hydroxylase
- Cytochrome P450 143
- Putative cytochrome P450 141
- Possible oxygenase
- Probable second part of macrolide-transport ATP-binding protein ABC transporter
- Probable first part of macrolide-transport ATP-binding protein ABC transporter
- Peptide synthetase MbtE
- Methyl-branched lipid omega-hydroxylase-3-oxocholest-4-en-26-oate forming])
- Probable polyketide synthase Pks17
Sequence:
MRYPLGEALLALYRWRGPLINAGVGGHGYTYLLGAEANRFVFANADAFSWSQTFESLVPVDGPTALIVSDGADHRRRRSVVAPGLRHHHVQRYVATMVSNIDTVIDGWQPGQRLDIYQELRSAVRRSTAESLFGQRLAVHSDFLGEQLQPLLDLTRRPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTAPRPDDHMLTTLISGCSEEGTTLSDNEIRDSIVSLITAGYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETLRLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQLPAQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ
Protein: 23S rRNA (cytidine-2'-O)-methyltransferase TlyA (EC 2.1.1.226) (23S rRNA (cytidine1920-2'-O)-methyltransferase) (Hemolysin A) (A0A0H3PEK7)
Organism: Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Function: Catalyzes the 2'-O-methylation at nucleotide C1920 in 23S rRNA. Enhances motility. Enchances biofilm formation. Involved in the assembly of 70S ribosomes. Involved in virulence by promoting adherence and invasion to host cells. Involved in pathogenicity by modulating secretion of host-protective chemokine interleukin 8 (IL-8). Involved in susceptibility to antibiotic capreomycin.
Interaction partners:
Sequence:
MRFDFFVSKRLNISRNKALELIENEEVLLNGKSFKASFDVKNFLENLKKTQDLNPEDILLTDGLKLDLLSEIYVSRAALKLKNFLEENGIEIKHKNCLDIGSSTGGFVQILLENQALKITALDVGNNQLHLSLRTNEKIILHENTDLRTFKSEEKFELITCDVSFISLINLLYYIDNLALKEIILLFKPQFEVGKNIKRDKKGVLKDDKAILKARMDFEKACAKLGWLLKNTQKSSIKGKEGNVEYFYYYIKN
Protein: Heat shock protein 83 (P12861)
Organism: Trypanosoma brucei brucei
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNSSDACDKIRYQSLTNQSVLGDEPHLRIRVIPDRVNKTLTVEDSGIGMTKADLVNNLGTIARSGTKSFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNEDDAYTWESSAGGTFTVTSTPDCDLKRGTRIVLHLKEDQQEYLEERRLKDLIKKHSEFIGYDIELMVENTTEKEVTDEDEDEEAAKKAEEGEEPKVEEVKDGVDADAKKKKTKKVKEVKQEFVVQNKHKPLWTRDPKDVTKEEYASFYKAISNDWEEQLSTKHFSVEGQLEFRAILFLPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPEWLGFLRGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKALELFEELAGNKEDYKKFYEQFSKNVKLGIHEDSTNRKKLMELLRFHSSESGEEMTTLKDYVTRMKEGQKCIYYVTGDSKKKLETSPFIEQARRRGMEVLFMTDPIDEYVMQQVKDFEDKKFACLTKEGVHFEETEEEKKQREEEKASYERLCKAMKEVLGDKVEKVVVSDRLATSPCILVTSEFGWSAHMEQIMRNQALRDSSMSAYMMRKKTMEINTTHAIVKELKRRVEADENDKAAKDLIFLLFDTSLLTSGFTLDDPTAYADRIHRMIKLGLSLDDDAEEEEAQAPVAAAANSSTGASGMEEVD
Protein: Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4) (O75081)
Organism: Homo sapiens (Human)
Function: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation.
Subcellular location: [Isoform 1]: Nucleus, nucleolus. Note=The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleoplasm {ECO:0000269|PubMed:11823486}. Golgi apparatus membrane {ECO:0000269|PubMed:11823486}.
Interaction partners:
- LIM domain-binding protein 1
- LIM domain-binding protein 2
- Runt-related transcription factor 1
- T-cell acute lymphocytic leukemia protein 1
- Erythroid transcription factor
- Protein CBFA2T2
- Histone deacetylase 1
- Transcription factor E2-alpha
- Protein lyl-1
- Nuclear receptor corepressor 1
Sequence:
MPASRLRDRAASSASGSTCGSMSQTHPVLESGLLASAGCSAPRGPRKGGPAPVDRKAKASAMPDSPAEVKTQPRSTPPSMPPPPPAASQGATRPPSFTPHTHREDGPATLPHGRFHGCLKWSMVCLLMNGSSHSPTAINGAPCTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASASSPIDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPEHLSKRPCTLNPAQRYSPSNGPPQPTPPPHYRLEDIAMAHHFRDAYRHPDPRELRERHRPLVVPGSRQEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWARRYSDAEDTKKGPAPAAARPRSSSAGPEGPQLDVPREFLPRTLTGYVPEDIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHRDWEKHHHVCGQSLQGPTAVVADPVPGPPEAAHSLGPSLPVGAASPSEAGSAGPSRPGSPSPPGPLDTVPR