wanglab/gogpt-training-data huggingface dataset:
Protein: Protein SIP5 (SNF1-interacting protein 5) (P40210)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May negatively regulate the SNF1 kinase by promoting the interaction of the REG1/GLC7 phosphatase complex with the kinase. Deletion of SIP5 promotes resistance to artimisin, which is probably an indirect effect of an action on the electron transport chain.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ubiquitin-conjugating enzyme variant MMS2
- Transcription initiation factor IIF subunit beta
- Ubiquitin-conjugating enzyme E2 13
- Pyruvate carboxylase 1
- Carbonic anhydrase
- Serine/threonine-protein kinase VHS1
- Serine/threonine-protein phosphatase PP1-2
- Carbon catabolite-derepressing protein kinase
Sequence:
MGNVPGKIDQEDSFNDVRPDSSYNTTSSNSVIKQYDEEASSRVRTRRTTSLVNNILNGNNARTKTGSHLSSTSRRKTSREKELAKEAHAKQLVVRCSETVDGGFLAPFGCYSFEKLDYDATVVKNLIIKRKLAPFYTPLQDFDESWTRDELIKIVDGLPLHDTFDENLEEFEDVPIGNLRKSTFNELIDKSLSKKEQRRMHAKIFRARLYKKRILWQENENETFLERKLEMKRIGSKSSNVEDNTSSQPRKNYHLPSDDLKYTLYKNGSECPICFLYFPGPFNYSKCCQQPICTECFVQIKRADPHFPHDEVDPTEPQTNDSEKDPNLLTSEPANCPYCATASFSITYQPPTNRETGIGGMPADSYVYKDAAISRADGGQPNISAITSDTIRPDWEIKLNKERARLMRRSANATAIHISNRLIDPSHSRRRNTSHSITPIHDESTSASRSPEPTINELEDQMVREAIRLSLEDQDNRKKSKNRNTSLRP
Protein: Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) (Q9VAN6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in histone pre-mRNA 3' processing and couples histone mRNA production with the cell cycle. Both maternal and zygotic proteins play an essential and vital function for development.
Interaction partners:
- FI05704p
- Lsm10
- Symplekin
- Nuclear cap-binding protein subunit 1
- Cleavage and polyadenylation specificity factor 73
- Regulator of nonsense transcripts 1 homolog
- Nuclear cap-binding protein subunit 2
- LP20791p
- RE28271p
- Cleavage stimulation factor 64 kD subunit
Sequence:
MLCEDQHMSVENTPQKGSGSLNSSASSISIDVKPTMQSWAQEVRAEFGHSDEASSSLNSSAASCGSLAKKETADGNLESKDGEGREMAFEFLDGVNEVKFERLVKEEKLKTPYKRRHSFTPPSNENSRSNSPNSSNSSANGDAAAPKGGNNPHSRNSKKSGNFRAHKEEKRVRHNSYTSSTSSSSSYTEADPAILSRRQKQIDYGKNTAAYERYVEMVPKDERTRDHPRTPNKYGKYSRRAFDGLVKIWRKSLHIYDPPTQARDTAKDSNSDSDSD
Protein: Probable E3 ubiquitin-protein ligase sinah (EC 2.3.2.27) (RING-type E3 ubiquitin transferase sinah) (Sina homolog) (Q8T3Y0)
Organism: Drosophila melanogaster (Fruit fly)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. The adapter phyl is required to direct the degradation of the two isoforms of the transcriptional repressor Tramtrack (Ttk). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. A phyl-independent mechanism of degradation exists for isoform beta of ttk that involves motifs in the C-terminus of ttk.
Interaction partners:
- Calcyclin-binding protein
- Protein phyllopod
- Ubiquitin-conjugating enzyme E2-17 kDa
- F-box-like/WD repeat-containing protein ebi
- Armadillo segment polarity protein
- E3 ubiquitin-protein ligase sina
- LP03867p
- Male sterile
- FI13205p
- GH20441p
Sequence:
MSVRNSRPQLSWPERVSPQRTIDTPTASGEMLTRRQSAPALVVPPEETTHVVVVKRQSPDAAAAGELVPSRRKDSVAVQSGIVATGPLDTTRSGARDDFLMALLECPVCFGYIMPPIMQCPRGHLICSTCRSKLTICPVCRVFMTNIRSLAMEKVASKLIFPCKHSHFGCRARLSYAEKTKHEEDCECRPYFCPYPDDKCSWQGPLRDVYQHLMSSHENVITMEGNDIIFLATNVNLEGALDWTMVQSCHGRHFLLSLEKINLGEDCQQYFTACRMIGSMKDAAEFVYNISLEAYNRTLRWQSKPRSIRENFSSFTNADFLVLNKHTVELFSEDGNLALNVVIRKVEERTN
Protein: Taiman, isoform G (M9ND53)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ecdysone receptor
- Protein ultraspiracle
- histone acetyltransferase
- Ecdysone-induced protein 75B, isoform B
- ETV5-related protein Ets96B
- histone acetyltransferase
- Nuclear hormone receptor HR96
- Estrogen-related receptor splice variant
- Mediator of RNA polymerase II transcription subunit 1
- Probable nuclear hormone receptor HR3
Sequence:
MSIAAAENAGLSPSDLPDHWASGTSNPSTSTSSSSSSSISASGSNNNKYNSGNISVCNLPRSSPAAATAAVTLSSAAGGIGSNLLSGLHHGLAPGTHPLQRATAASGGGAGAGGVAGASTAAALTLQQHQHQQQQQQQQQQAQHQHQHQHQQQTQQQQLAYQHQQLQQQIISHRSIQNKAAATAAAQTANLAAALQRSAAIMNAVASPISANSANSATSGRKIRRKTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKRGDMTSTKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQTSSNCEEKPLRQSGHQDKYEEVVLIAAPVKDDADASSSVLCLITRPEDESPLEINIQQHVQQQPIEQMTFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQDLCHPHDLSTLKSHLRDIQDSASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAASGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASPAPAEHSFYGSDTFEFDIAAHSSSFELDPSGGVGAWTDSRPNSRASVATPVSTPRPPSGHGFSPAVCASPATPYQLSSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDVKPEKDVQQQQNQQQSNNNSSSSNPLLGGGLPNGVGGMLLSQQQQQQQTPPQQQQQQQQQESSERLRHLLTKSQSMAGGLGGLGDDEKYFKPEGSEEEKHASGGFKMGGQPGGMGMFGPMGSMGRGVGNSSMLHKAGNSQNPMLLKLLNEKSEDDDGNGSGGGPGSMNNSRQSELMRQLKNPDGGSHGMHRNSASGNMSTEDLKAMLKIQSDPSLNRKRSLNEPDDDPSAKRSEDKPSKLCTQNKMLAKLLQNPPKIPKAPNPEQPLQVKTLPDITSSTVSSTLAAPGNLISAGSTGPKAAANRNRKQQQQQQQQQQQQQQQQVAGIPSQQQQQQPNDVYLSQQQQQQLQSPQLAFQHQQLATTATTSITTAASTSAAAAAAAAILGEGDSELSKLLDSVMEYYPDDTPIVTNAPSEASAINDIQKSLMLDVESAAFGNDLNQQLMMTQQQQHQQQQQQQQLLALQLAQQQQQQRQQHLQQPPAYPGMLNMQQQQHQQQQQQNQQHIMQRLEAMRNQGNQGFQRPPPMYPARGRGPMNAVATPGGVVLPAQQQLRNIRQQQQLAAAQQKERLLQQQQKQQLLVPENASEYWGNSNLQLIIKLIVSYILAGMNAGLNNIGSLLNTTGAPNVSLSRTNLPSDAQLSPNFAQTLMQQQLSPGRSAPYSPQPNQGYAPQFPQPGQRLSPQQQQQLSQQQQNNVQQQQLAYQQQQVGDGGRSNTPFGSNSGMQSPGMQNSPQQWGSGGGGGGGPGGPLPSGNAGRTLQQHNPMLIAQLQGVSPYNARQYQQNQRRGLNSPGAVGPGGNPAAQAALQRQNSFQGQGGGGATTPDGSGVGFGGPQSPYGTNVNVFQQQQLQRLQRQGSVPQATQHLPGSPRFGSSPGSSNNTDSSAAAGNQQQQQQQQQQQQQQHQQQQHQQLMNGLSMSPHPHPHPAMMGVGGMGSGGGNGIIGLGGGGGNYGATLGGYGQSQQANDFYGRAQTAGGGGSVAGGNANSEFVKQELRAVVSVRAQQAAAAATGGAGVGGGVAQRGQTPQSPLQQGSVIGGGGGIVGGVNSTNTMGNVTPTGSGNVSNSMLNTPPDPTLSFSFETPDFFTSSATR
Protein: Xyloglucan O-acetyltransferase 1 (EC 2.3.1.-) (Protein ALTERED XYLOGLUCAN 4) (Protein TRICHOME BIREFRINGENCE-LIKE 27) (O04523)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Xyloglucan acetyltransferase that catalyzes the acetylation of fucosylated Gal residues on xyloglucan side chains. Predominantly catalyze 6-O-monoacetylation of Gal residues in the Fuc-Gal-Xyl trisaccharide side chains of xyloglucan oligomers. Involved in xyloglucan specific O-acetylation in roots and rosette leaves.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Protein REDUCED WALL ACETYLATION 2
- Protein REDUCED WALL ACETYLATION 1
- Protein REDUCED WALL ACETYLATION 4
- Protein REDUCED WALL ACETYLATION 3
- Alpha-L-fucosidase 2
- Xyloglucan galactosyltransferase MUR3
Sequence:
MGLNEQQNVPSQRKIIVFIVLAFIPIALFRLCFNNPFSSIKDTSLQDSAANVVITSFSSSSQEEESQESFDHIQDEPLCDYTQGNWVRDEIGPLYNGSTCGTIKDGQNCFRHGRPDSGYLYWKWKPNECDIPRFDSNRFLDLMRDKHLAFIGDSMARNQLESLLCLLSTVSSPDLVYRNGEDNKFRRWRFESHNVTVSVYWSPFLVAGLEKSGNLDHNVLHIDRVDERWGNDLERFDTVVVSVGHWFLHPAVYYESGSVLGCHSCETSNCTEVGFYDVFRKAIRTTLRAVAGSGREVILTTFSPSHFEGRPWDSLGACNMTKPYEGKVLEGLDLDMRKIEIEEYTAAAAEVRLEVLDVTAMSVLRPDGHPGPYMYADPFKNGVPERIPNDCLHWCLPGPVDTWNEIMIEMLRRWKV
Protein: CD40 molecule (A0A8I5XVD8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLPLPQLCALWGCLLTAVHLGQCVTCSDKQYLQGGECCDLCQPGNRLVSHCTALEKTQCQPCDSGEFSAHWNREIRCHQHRHCELNQGLQVKKEGTAVSDTVCTCKEGQHCASKECETCAQHTPCGPGFGVVQMATETTDTVCQPCPVGFFSNGSSLFEKCHPWTRFPAPDASPAGHSRRDGHPHHHLCGFSLYQKGGQETKGQ
Protein: Type VI lipoprotein IgE-like C-terminal domain-containing protein (A0Q7H2)
Organism: Francisella tularensis subsp. novicida (strain U112)
Interaction partners:
Sequence:
MYNKLLKNLCLVLSTIIGLSSCISDGLYINNNIPKTKIVLESKPDKNIFYSDNYQSISQRIYDDNVKVLNLKTGKNEFPLDKDIKDYALYFILPENKKTENWKYLISSDSVNEFTIKNDSSIEKD
Protein: Evasin P985 (A0A023FT45)
Organism: Amblyomma parvum (South American tick)
Function: Salivary chemokine-binding protein which binds to host chemokine CCL5.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MHSTIAYVSLLPLALFVAMHGASTDEESEELGASTDVDYEELDANCTCPAPALTSTRNNKHYPLGCIYNCSSYNCTIPDGTPCYVLTLGEVKEHLQIGSTVPNCTCGLCRNGTCVSNGTVEECFAVEEIEET
Protein: RE02671p (Q8SZF1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTNFLDQLPKHIREIAEQVNVLAPEEVLTTPKVRFLDTRQQSLHTIVRKCTPDDVRVLKDAAAKWLAEMPQSADSLFKPLVNVRWSRVSFGCSALDRCTGGGVVTRGITELCGAAGVGKTELLLQLSLCVQLPRELGGLGKGVAYICTESSFPARRLLQMSKACEKRHPEMELNFLGNIFVENHIEAEPLLACVINRIPRLMQQHGIGLIIIDSVAAIFRLYNDYLERARHMRRLADALLSYADKYNCAVVCVNQVATRDGQDEIPCLGLQWAHLGRTRLRVSRVPKQHRMGDQLITVRKLEILYSPETPNDFAEFLITAEGVVNVPEPSVPSPPAKMRRL
Protein: AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) (O43299)
Organism: Homo sapiens (Human)
Function: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20613862}. Nucleus {ECO:0000269|PubMed:20613862}. Note=By SDS-PAGE, 2 isoforms have been observed, the shorter seems to be predominantly nuclear and the longer is mostly cytoplasmic. {ECO:0000269|PubMed:20613862}.
Interaction partners:
- AP-5 complex subunit beta-1
- AP-5 complex subunit sigma-1
- Spatacsin
- Zinc finger FYVE domain-containing protein 26
- AP-5 complex subunit mu-1
- AP-4 complex subunit sigma-1
- AP-4 complex subunit beta-1
- AP-4 complex subunit epsilon-1
- AP-4 complex subunit mu-1
- AP-3 complex subunit sigma-2
Sequence:
MFSAGAESLLHQAREIQDEELKKFCSRICKLLQAEDLGPDTLDSLQRLFLIISATKYSRRLEKTCVDLLQATLGLPACPEQLQVLCAAILREMSPSDSLSLAWDHTQNSRQLSLVASVLLAQGDRNEEVRAVGQGVLRALESRQPEGPSLRHLLPVMAKVVVLSPGTLQEDQATLLSKRLVDWLRYASLQQGLPHSGGFFSTPRARQPGPVTEVDGAVATDFFTVLSSGHRFTDDQWLNVQAFSMLRAWLLHSGPEGPGTLDTDDRSEQEGSTLSVISATSSAGRLLPPRERLREVAFEYCQRLIEQSNRRALRKGDSDLQKACLVEAVLVLDVLCRQDPSFLYRSLSCLKALHGRVRGDPASVRVLLPLAHFFLSHGEAAAVDSEAVYQHLFTRIPVEQFHSPMLAFEFIQFCRDNLHLFSGHLSTLRLSFPNLFKFLAWNSPPLTSEFVALLPALVDAGTALEMLHALLDLPCLTAVLDLQLRSAPAASERPLWDTSLRAPSCLEAFRDPQFQGLFQYLLRPKASGATERLAPLHQLLQPMAGCARVAQCAQAVPTLLQAFFSAVTQVADGSLINQLALLLLGRSDSLYPAPGYAAGVHSVLSSQFLALCTLKPSLVVELARDLLEFLGSVNGLCSRASLVTSVVWAIGEYLSVTYDRRCTVEQINKFFEALEALLFEVTQCRPSAALPRCPPQVVTVLMTTLTKLASRSQDLIPRASLLLSKMRTLAHSPATSSTHSEEGAEAIRTRATELLTLLKMPSVAQFVLTPSTEVCSPRYHRDANTALPLALRTVSRLVEREAGLMPG
Protein: Proliferating cell nuclear antigen 2 (PfPCNA2) (Q7KQJ9)
Organism: Plasmodium falciparum (isolate 3D7)
Function: May be involved in DNA damage response. Appears not to be involved in DNA replication in trophozoites.
Subcellular location: Nucleus {ECO:0000269|PubMed:26251451}. Chromosome {ECO:0000269|PubMed:26251451}. Cytoplasm {ECO:0000269|PubMed:26251451}. Note=Unlike PCNA1, does not localize to nuclear foci (PubMed:26251451). Enriched in the nucleus in response to DNA damage (PubMed:26251451). {ECO:0000269|PubMed:26251451}.
Interaction partners:
- Replication factor C subunit 2, putative
- Replication factor C subunit 3, putative
- Replication factor C subunit 5, putative
- DNA ligase
- Replication factor C subunit 4, putative
- 3'-5' exonuclease
- DNA polymerase
- Proliferating cell nuclear antigen 1
- DNA polymerase delta small subunit, putative
- Replication factor C subunit 1
Sequence:
MFECRIDGQFFKKLFETLKDICTEVNLECDENGIKMQSMDCSHVSLVDLNIVSDFFQHYRCDKNCVLGISINFMLKILSVIKEKSTVFLFKEDNENDAVLNIGIIDEEEQSSADDSLEIQVKLINAQKEHLEIPQSEYHCQCTMKSKKFQEFTKYLNSIGDNVSISMKKDAMILSTTGSDIKVTKQFTNDMTDISITCTKSVSQEFATRYLVMFSRASSLSDEVLISLSPHIPISIKFNFKQQLTDLQDPSHLTFFLAPKIGDY
Protein: S-adenosylmethionine decarboxylase proenzyme 4 (AdoMetDC4) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase 1 alpha chain; S-adenosylmethionine decarboxylase 1 beta chain (Protein BUSHY AND DWARF 2)] (Q3E9D5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development.
Interaction partners:
- Spermidine synthase 1
- Spermine synthase
- Spermidine synthase 2
- S-adenosylmethionine synthase 2
- Thermospermine synthase ACAULIS5
- S-adenosylmethionine synthase 1
- S-adenosylmethionine synthase 3
- S-adenosylmethionine synthase 4
- Arginine decarboxylase 2
- Arginine decarboxylase 1, chloroplastic
Sequence:
MAVSGFEGFEKRLELRFFDDDKPITKNPMGLRLIDFESLDQVLNEVQCTVVSAVANRSFDAYVLSESSLFVYPTKIIIKTCGTTQLLKSIRPLIHLARNLGLTLRACRYSRGSFIFPKAQPFPYTSFKDEVIVVEESLPKSLCYRKASVMTPSNNPSRAWHVFTASADVESDEHVVVVEVCMTELDRVNARSFFKRKGDEKNNSDSAGKEMTRLSGIDNINANAYICDFAFDPCGYSMNGVDGDRYSTIHVTPEDGFSYASFECGLSLYDNGHEDISEVLSRAIDVFRPSDVSIATTYGGEDYNHEVTKRVERVLAKKLDLKCRSRLMDEFPGSGTVVYQSFTPRRK
Protein: Lymphotoxin-alpha (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1) (P01374)
Organism: Homo sapiens (Human)
Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
Subcellular location: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 3
- Tumor necrosis factor receptor superfamily member 14
- Lymphotoxin-beta
- Tumor necrosis factor receptor superfamily member 1B
- Tumor necrosis factor receptor superfamily member 1A
- Tumor necrosis factor
- Tumor necrosis factor receptor superfamily member 5
- Interferon gamma
- Interleukin-1 beta
- CD40 ligand
Sequence:
MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL
Protein: Putative glycogen storage disease type 1b protein (Q9Z295)
Organism: Mus musculus (Mouse)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MAAQGYGYYRTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAAPWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPLPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSLYGNPRHGLLLLMMAGMAASTYLFRVTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNIRTKMGRVSKKGE
Protein: TNF receptor-associated factor homolog 1b (Protein MUTANT SNC1-ENHANCING 13) (A8MQL1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions redundantly with TRAF1A in the regulation of plant immune response. Contributes to the turnover of the nucleotide-binding domain and leucine-rich repeat-containing (NB-LRR) immune receptors SNC1 and RPS2. May associate with an E3 ubiquitin-protein ligase complex, which modulates ubiquitination and subsequent degradation of NB-LRR immune sensors to maintain their homeostasis. Functions redundantly with TRAF1A in the regulation of autophagosome formation. Required for SINAT1- and SINAT2-mediated ubiquitination and destabilization of ATG6. Functions as molecular adapter that helps to regulate autophagy by modulating ATG6 stability.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26867179, ECO:0000269|PubMed:28351989}. Cell membrane {ECO:0000269|PubMed:26867179}; Peripheral membrane protein {ECO:0000305|PubMed:26867179}. Note=Predominantly expressed in the cytoplasm (PubMed:26867179, PubMed:28351989). Associates with starvation-induced autophagosomes in continuous darkness (PubMed:28351989). {ECO:0000269|PubMed:26867179, ECO:0000269|PubMed:28351989}.
Interaction partners:
- Putative E3 ubiquitin-protein ligase SINAT1
- Choline transporter-like protein
- E3 ubiquitin-protein ligase SINAT2
- Beclin-1-like protein
- Probable inactive E3 ubiquitin-protein ligase SINAT6
- Protein SWEETIE
- Autophagy-related protein 13a
- Autophagy-related protein 13b
- Cytochrome c-type biogenesis protein CcmE homolog, mitochondrial
- Actin cross-linking protein, putative
Sequence:
MAEAVDEDSGVGRSLEESSNGQHSQAGEALSEWRSSGQVENGTPSTSPSYWDIDDDDDYGLKPSELYGQYTWKIPKFSEITKREHRSNVFEAGGYKWYILIYPQGCDVCNHLSLFLCVANYDKLLPGSFAILEAGWSQFAQFTISVLSQDLKKSKFSDTLHRFWKKEHDWGWKKFMELPKLKDGFIDESGCLTIEAKVQVIRERVDRPFRCLDCGYRRELVRVYFQNVEQICRRFVEEKRSKLGRLIEDKARWTSFGVFWLGMDQNSRRRMCREKVDVILKGVVKHFFVEKEVSSTLVMDSLYSGLKALEGQTKNMKARSRLLDAKQLPAPIVSVDKDMFVLVDDVLLLLERAALEPLPPKDEKGRQNRTKDGNDGEEVNKEADERDERRLTELGRRTVEIFILSHIFSTKIEVAHQEAIALKRQEELIREEEEAWLAETEQRAKRGAAEREKKSKKKQAKQKRNKNKGKDKRKEEKVSFATHAKDLEENQNQNQNDEEEKDSVTEKAQSSAEKPDTLGDVSDISDSVDGSADILQPDLEDRDSSSVLWDTDALEIHPPSSEGSSRGRGISISTPNGITEGKSHSTMDDSSSTCSNDSIRSGVTNGSYQGNSLNFRNQKSPNKGKNQQVKAMTDAHSLASETDDQPSTLGTDPKGQNYSSEASNVGESDWVVVSHIQEPEGSRNRIPVGRERKTVQSIVNSVDMDRPKEKSTAVLSSPRNVAKNPSPLTQTKPEKKSISTADGIPNRKVLATGPPSSSQVVLPSDIQSQTVGLRADMQKLSAPKQPPATTISRPSSAPIIPAMRPSPITVSSSVQTTTSLPRSVSSAGRLGPDPSLHNQQTYTPQSYKNAIVGNSLGSSSSSFNHHPSSHGVVPTTLPSSSYSQAPTSSYQSSFPYSQDGLLWTGRSPSSVNMGMYNNTYSPAVTSNRSLNHMDVQIAQQQAQSMMTDEFPHLDIINDLLEDEQCSNMVYNGSIFNPQPQVFNGQYSSYHGELLSGGRTRSFGEEGLHYMARGPYGTDGMMPRQWQMTNMDLSLPAMRSNGMEDGTSSAANYHHSYFGLDASNPSFTSGINGYTEFRPSNGH
Protein: Aconitate hydratase A (ACN) (Aconitase) (EC 4.2.1.3) ((2R,3S)-2-methylisocitrate dehydratase) ((2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase) (Iron-responsive protein-like) (IRP-like) (Probable 2-methyl-cis-aconitate hydratase) (EC 4.2.1.99) (RNA-binding protein) (O53166)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. The apo form of AcnA functions as a RNA-binding regulatory protein which binds to selected IRE-like sequences present within the UTRs (untranslated regions) of 3' trxC and 5' IdeR mRNA. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate (By similarity).
Interaction partners:
- Citrate synthase 1
- Putative citrate synthase 2
- 2-methylcitrate synthase
- Isocitrate dehydrogenase 1
- Isocitrate dehydrogenase 2
- Superoxide dismutase
- Isocitrate lyase
- Putative isocitrate lyase subunit A
- Putative isocitrate lyase subunit B
- HTH-type transcriptional repressor Rv1474c
Sequence:
MTSKSVNSFGAHDTLKVGEKSYQIYRLDAVPNTAKLPYSLKVLAENLLRNEDGSNITKDHIEAIANWDPKAEPSIEIQYTPARVVMQDFTGVPCIVDLATMREAIADLGGNPDKVNPLAPADLVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQGAFDDFKVVPPGTGIVHQVNIEYLASVVMTRDGVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFRLTGEIQPGVTATDVVLTVTEMLRQHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIFPIDEETIKYLRFTGRTPEQVALVEAYAKAQGMWHDPKHEPEFSEYLELNLSDVVPSIAGPKRPQDRIALAQAKSTFREQIYHYVGNGSPDSPHDPHSKLDEVVEETFPASDPGQLTFANDDVATDETVHSAAAHADGRVSNPVRVKSDELGEFVLDHGAVVIAAITSCTNTSNPEVMLGAALLARNAVEKGLTSKPWVKTTIAPGSQVVNDYYDRSGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISKAVNDNDLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVIAYALAGTMDFDFQTQPLGQDKDGKNVFLRDIWPSQQDVSDTIAAAINQEMFTRNYADVFKGDDRWRNLPTPSGNTFEWDPNSTYVRKPPYFEGMTAKPEPVGNISGARVLALLGDSVTTDHISPAGAIKPGTPAARYLDEHGVDRKDYNSFGSRRGNHEVMIRGTFANIRLRNQLLDDVSGGYTRDFTQPGGPQAFIYDAAQNYAAQHIPLVVFGGKEYGSGSSRDWAAKGTLLLGVRAVIAESFERIHRSNLIGMGVIPLQFPEGKSASSLGLDGTEVFDITGIDVLNDGKTPKTVCVQATKGDGATIEFDAVVRIDTPGEADYYRNGGILQYVLRNILKSG
Protein: Cytochrome P450 4F1 (CYPIVF1) (Cytochrome P450-A3) (Leukotriene-B4 20-monooxygenase) (EC 1.14.14.94) (P33274)
Organism: Rattus norvegicus (Rat)
Function: A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its oxygenated derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. May play a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs.
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein {ECO:0000255}. Microsome membrane; Peripheral membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 2E1
- Cytochrome P450, family 2, subfamily j, polypeptide 4
- Cytochrome P450 2U1
- Cytochrome P450 4A10
- unspecific monooxygenase
- Cytochrome P450 4A2
- Prostaglandin G/H synthase 2
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Cytochrome P450 4A12
- Leukotriene A-4 hydrolase
Sequence:
MSQLSLSWLGLGPEVAFPWQTLLLFGASWILAQILTQIYAAYRNFRRLRGFPQPPKRNWLMGHVGMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYTILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWKRLISEGSSRLDMFEHVSLMTLDSLQKCVFSFDSNCQEKSSEYIAAILELSALVAKRHQQPLLFMDLLYNLTPDGMRFHKACNLVHEFTDAVIRERRRTLPDQGLDEFLKSKAKSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLANDPEYQERCRQEVQELLRDRDPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYNPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVEPLTAGAQ
Protein: Transposon Ty4-J Gag-Pol polyprotein (TY4A-TY4B) (Transposon Ty4 TYA-TYB polyprotein) [Includes: Capsid protein (CA); Ty4 protease (PR) (EC 3.4.23.-); Integrase (IN); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4)] (P47024)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MATPVRGETRNVIDDNISARIQSKVKTNDTVRQTPSSLRKVSIKDEQVRQYQRNLNRFKTILNGLKAEEEKLSEADDIQMLAEKLLKLGETIDKVENRIVDLVEKIQLLETNENNNILHEHIDATGTYYLFDTLTSTNKRFYPKDCVFDYRTNNVENIPILLNNFKKFIKKYQFDDVFENDIIEIDPRENEILCKIIKEGLGESLDIMNTNTTDIFRIIDGLKKQNIEVCMVEMSELEPGEKVLVDTTCRNSALLMNKLQKLVLMEKWIFSKCCQDCPNLKDYLQEAIMGTLHESLRNSVKQRLYNIPHDVGIDHEEFLINTVIETVIDLSPIADDQIENSCMYCKSVFHCSINCKKKPNRELGLTRPISQKPIIYKVHRDNNHLSPVQNEQKSWNKTQKRSNKVYNSKKLVIIDTGSGVNITNDKTLLHNYEDSNRSTRFFGIGKNSSVSVKGYGYIKIKNGHNNTDNKCLLTYYVPEEESTIISCYDLAKKTKMVLSRKYTRLGNKIIKIKTKIVNGVIHVKMNELIERPSDDSKINAIKPTSSPGFKLNKRSITLEDAHKRMGHTGIQQIENSIKHNHYEESLDLIKEPNEFWCQTCKISKATKRNHYTGSMNNHSTDHEPGSSWCMDIFGPVSSSNADTKRYMLIMVDNNTRYCMTSTHFNKNAETILAQVRKNIQYVETQFDRKVREINSDRGTEFTNDQIEEYFISKGIHHILTSTQDHAANGRAERYIRTIITDATTLLRQSNLRVKFWEYAVTSATNIRNYLEHKSTGKLPLKAISRQPVTVRLMSFLPFGEKGIIWNHNHKKLKPSGLPSIILCKDPNSYGYKFFIPSKNKIVTSDNYTIPNYTMDGRVRNTQNINKSHQFSSDNDDEEDQIETVTNLCEALENYEDDNKPITRLEDLFTEEELSQIDSNAKYPSPSNNLEGDLDYVFSDVEESGDYDVESELSTTNNSISTDKNKILSNKDFNSELASTEISISGIDKKGLINTSHIDEDKYDEKVHRIPSIIQEKLVGSKNTIKINDENKISDRIRSKNIGSILNTGLSRCVDITDESITNKDESMHNAKPELIQEQLKKTNHETSFPKEGSIGTNVKFRNTNNEISLKTGDTSLPIKTLESINNHHSNDYSTNKVEKFEKENHHPPPIEDIVDMSDQTDMESNCQDGNNLKELKVTDKNVPTDNGTNVSPRLEQNIEASGSPVQTVNKSAFLNKEFSSLNMKRKRKRHDKNNSLTSYELERDKKRSKKNRVKLIPDNMETVSAPKIRAIYYNEAISKNPDLKEKHEYKQAYHKELQNLKDMKVFDVDVKYSRSEIPDNLIVPTNTIFTKKRNGIYKARIVCRGDTQSPDTYSVITTESLNHNHIKIFLMIANNRNMFMKTLDINHAFLYAKLEEEIYIPHPHDRRCVVKLNKALYGLKQSPKEWNDHLRQYLNGIGLKDNSYTPGLYQTEDKNLMIAVYVDDCVIAASNEQRLDEFINKLKSNFELKITGTLIDDVLDTDILGMDLVYNKRLGTIDLTLKSFINRMDKKYNEELKKIRKSSIPHMSTYKIDPKKDVLQMSEEEFRQGVLKLQQLLGELNYVRHKCRYDIEFAVKKVARLVNYPHERVFYMIYKIIQYLVRYKDIGIHYDRDCNKDKKVIAITDASVGSEYDAQSRIGVILWYGMNIFNVYSNKSTNRCVSSTEAELHAIYEGYADSETLKVTLKELGEGDNNDIVMITDSKPAIQGLNRSYQQPKEKFTWIKTEIIKEKIKEKSIKLLKITGKGNIADLLTKPVSASDFKRFIQVLKNKITSQDILASTDY