Protein: Helicase domino (EC 3.6.4.-) (Q9NDJ2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549, ECO:0000269|PubMed:11262242}.
Interaction partners:
- RuvB-like helicase 1
- RuvB-like helicase 2
- DNA methyltransferase 1-associated protein 1
- Actin-related protein 5
- Brahma associated protein 55kD
- Transcription-associated protein 1
- Enhancer of polycomb-like protein
- Histone acetyltransferase Tip60
- MRG/MORF4L binding protein
- LD10749p
Sequence:
MNEGNSAGGGHEGLSPAPPAVPDRVTPHSTEISVAPANSTSTTVRAAGSVGAALPATRHHQHIATQVKGIASSSSKQQKQLASAQLPVPLSPLPQQQQQTAEATAAAAAPAHSNVSVSSSTIEASVLPPQAKRQRLDDNEDRTSAASIVGPAESSNIVSSLLPASVASSSEVGGLSSTALQDLNALKKRILQQKLQILRNLKERHLENVSEYFYLQNGGSMMDYPAWRKKTPTPQFISYSNANRIDQLIHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIGTGATKGAPLDGNISNSTVKTNTQSQVPSKIGSFTESTPAATESNSSTTVPGTATSGAATSTSATSAEASGNVLAVEAEIKIPAVGATPVAISTKLPAAVVQLTQQGGTPLLPCNTSAGSTALRRPQGQNNASSGSAAASGGGGSLTPTPLYTGNGPAALGGSGGLTPGTPTSGSLLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKREWEANRLAAMHKEEELLKQETEAEEMLTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYIDYSLSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPNKMRREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTEPEAMAEWCVFEDMAILHVLVNLQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFSAPSLMNPKHMEVLQEFGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPPLPQQQQPQQVVQQVQQQQQQQQQQQQQQVVQQQLPTVSNVQQTLPVQQTVELVQQQPTTTTTVAVPAAGGQLQQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTIVGTSSSLTAGQLQQLAQQSAVASGGQSSVSVVLTTPVQTLPSVVQPQIGSGAQIVSISSQTLPVNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQHQTTAVTTLNTTMLRGQRIVSTAAGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRLAAVPTSPATQTTQLVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTTQAVPSGSAGATGATANLVQAGGTIIQASNMATHVTSQKVAVSGMPGTSTTVQAGNVVSSVQMHGQARTQFIKQMAAGKQQLQRQVVSADGTTTTTAAGDMLLVKRHNILAAQKAQQASGALFTTTTGQQQQQQQQQGQLPVAGQPQQVTQHQIASLVKASTAAAASGSSVNAGGVTVSATNPTVQAGSVNMTLPQLKPGSQIKVTMPNQMRHLQMQQQLTMPRKISRMTQLVSASGQPTATNIITTTGPQQQQQGVTVSGGGTLPTVASQQQQQQHQQKVGGGNSVQAQLLHIQNTKGLSNSVTMQQIQQVMRSGQQGTLATTNLVLGKTSVGRVIPVSVASQANQRQTIQVVSAASAQALAAGNLRTHVAGPSIASTLKVAAPGSAGGQTTQQTLIAALQHNQRQNASPVRLQTTAGGNLLAVVQQQQQQQHTSIAGPTAGPAEVMTITQTTTTLPTVGSLQQQQQQQQQQGGISQPTTQQVRKLVQKKILIRSEKE