wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2) (Q3LAC4)
Organism: Mus musculus (Mouse)
Function: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase (By similarity).
Interaction partners:
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Cell division control protein 42 homolog
- Ras-related C3 botulinum toxin substrate 1
Sequence:
MSDESAREVDKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAKVDKNVTEETVKMLFSNIEEILIVHKEFLKVVEECLYPEPSAQQEVGACFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRRHSDYTAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQAHIEGWEGSNITDTCTEMLMCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGYRYVFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDGAGDAFECKVEDVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERIEHVCHRISSYGRFSRVLKNRAWPTFKQAKPKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSVEPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLQYLLKEEDLETQDIYHKLLGKLQTALKEVEMSVCQIDDLLSSITYSPKLERKTTECVTPMDSDNEKGERNSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPISVRISHDKQDKIHTCLEQLFSQIDSIINLLKGQAVIRAFEQTKYLTPGRGLQEFQQEMEAKLSCPRRLRLHLKQDPWNLPSSIQALAQSIRKHAEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETCEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEDPLVANVPLTYQVEGSRQALKVYFYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRAFYLDKSNSPPNTTSKAAYIDKLMKPLNALDELYRLITSFIRSKRIAACVNTPCSASGVGLLSVSSELCDRLGACHIIMCSSGVHRCTLSVTLEQTITLARSHGLPPRYIMQAMDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGEE
Protein: Putative uncharacterized protein FYV1 (Q99341)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MSLYQSIVFIARNVVNSITRILHDHPTNSSLITQTYFITPNHSGKNISFHLFHDFKYCSADTRHYSQLIIFPVKENSRPTQVSRPLGGRPHESVFLPKFTRTQNSYCLTRLDRMGFPPPRKASTIMHFFQDDRTVMCSPKDGIPVSSFHIMICFLERRKGN
Protein: Complement C1q tumor necrosis factor-related protein 2 (Q9BXJ5)
Organism: Homo sapiens (Human)
Function: Involved in the regulation of lipid metabolism in adipose tissue and liver.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Neurocalcin-delta
Sequence:
MIPWVLLACALPCAADPLLGAFARRDFRKGSPQLVCSLPGPQGPPGPPGAPGPSGMMGRMGFPGKDGQDGHDGDRGDSGEEGPPGRTGNRGKPGPKGKAGAIGRAGPRGPKGVNGTPGKHGTPGKKGPKGKKGEPGLPGPCSCGSGHTKSAFSVAVTKSYPRERLPIKFDKILMNEGGHYNASSGKFVCGVPGIYYFTYDITLANKHLAIGLVHNGQYRIRTFDANTGNHDVASGSTILALKQGDEVWLQIFYSEQNGLFYDPYWTDSLFTGFLIYADQDDPNEV
Protein: Cell wall protein PGA59 (GPI-anchored protein 59) (Q5AF39)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Cell wall protein necessary for cell wall integrity. Plays only a minor role in hyphal morphogenesis and is not critical to biofilm formation.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:19383685, ECO:0000269|PubMed:19687206}. Membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
Sequence:
MQFSSAIILSAVAGSALATYANSTVTDIATTVVTITSCEENKCHETEVTTGVTTVTEVETTYTTYCPLPTAKAPVASTSNSTTTPPVSTAEGAAAANAVPAVAAGLLALGAFM
Protein: Rho GTPase activating protein at 15B, isoform B (Q0KHR5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEQARPVPAPRRLYPELRPANYENIEIRRPNSPSNNINHNNIKKLNINAENLHGNCAEKKLPSSGQNKLILQENNSDSQQPIYGPDANENVQEPVYATPRPAPRQRLPPAGEPEDSYPDPDDEVPLRILRAAPQIPPKPLNILLDQRSSICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSGKFKSQSPGNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGRSLKHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGLPDLRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYDEALRSRPSPSDSPMSRNLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQEATYGKLFEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEGAVGGVPLPQAVIEEFDPLSSKCSTLARSNKSNELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNARLLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSKTTPPIEGDSPPTYLEAIGGSKDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRKASFRGANQRQSDVRVALQMVPRPSLSPLLIRYEGPLVRFPSGVVEDILKEMQNRKAILRERQFQTFLDQEMKTPREMIPLDTITTLQCVSNSRVTDTATHFYCFEITTSQPKNGNGAGDAMSSNPNLLMTSSSSGNVKQQRVSHLYGVGKESERGVWMQKILESLTNSLPVKYTCHYYRAGWCYLKNSITSEWSGTWLVLRKSQRRLIFVSEANGNVEKMDLRKARCIVLKESDESIDNLHVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERLLGKLTDSFVFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPCSADEIKREQAMLACLQKYYAAAETLKDAVKQSGDIKIWISLNPNPENKTEEKTQVNATISPTKTAYELCREYSAKMQLPTHQLTLYEVILNDSLERPLHHDTKVFDVILNWSYWPEEDRKHNYLVVRPVEMLREIQRAVKNLATVTPGKELRFADSRTKTFKTLQCELRDGKIVVSKKDKNDKTTIVREIFLQSSTAYLGCERKRDFPWSWAITFVERTQAQIMRSRDAPFIGHVLAGSEWGDRTIWYSSIWYCLYRDNILPPAEIIIK
Protein: Leucine-rich repeat receptor protein kinase MSP1 (EC 2.7.11.1) (Protein MULTIPLE SPOROCYTE 1) (Q8RZV7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Receptor-like kinase that plays important roles in restricting the number of cells entering into male and female sporogenesis. Involved in cell specification during anther development and initiation of anther wall formation.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- TPD1 protein homolog 1A
Sequence:
MVSNSFWLFILLVSFIPISAWAESRDISTLFTLRDSITEGKGFLRNWFDSETPPCSWSGITCIGHNVVAIDLSSVPLYAPFPLCIGAFQSLVRLNFSGCGFSGELPEALGNLQNLQYLDLSNNELTGPIPISLYNLKMLKEMVLDYNSLSGQLSPAIAQLQHLTKLSISMNSISGSLPPDLGSLKNLELLDIKMNTFNGSIPATFGNLSCLLHFDASQNNLTGSIFPGITSLTNLLTLDLSSNSFEGTIPREIGQLENLELLILGKNDLTGRIPQEIGSLKQLKLLHLEECQFTGKIPWSISGLSSLTELDISDNNFDAELPSSMGELGNLTQLIAKNAGLSGNMPKELGNCKKLTVINLSFNALIGPIPEEFADLEAIVSFFVEGNKLSGRVPDWIQKWKNARSIRLGQNKFSGPLPVLPLQHLLSFAAESNLLSGSIPSHICQANSLHSLLLHHNNLTGTIDEAFKGCTNLTELNLLDNHIHGEVPGYLAELPLVTLELSQNKFAGMLPAELWESKTLLEISLSNNEITGPIPESIGKLSVLQRLHIDNNLLEGPIPQSVGDLRNLTNLSLRGNRLSGIIPLALFNCRKLATLDLSYNNLTGNIPSAISHLTLLDSLILSSNQLSGSIPAEICVGFENEAHPDSEFLQHHGLLDLSYNQLTGQIPTSIKNCAMVMVLNLQGNLLNGTIPVELGELTNLTSINLSFNEFVGPMLPWSGPLVQLQGLILSNNHLDGSIPAKIGQILPKIAVLDLSSNALTGTLPQSLLCNNYLNHLDVSNNHLSGHIQFSCPDGKEYSSTLLFFNSSSNHFSGSLDESISNFTQLSTLDIHNNSLTGRLPSALSDLSSLNYLDLSSNNLYGAIPCGICNIFGLSFANFSGNYIDMYSLADCAAGGICSTNGTDHKALHPYHRVRRAITICAFTFVIIIVLVLLAVYLRRKLVRSRPLAFESASKAKATVEPTSTDELLGKKSREPLSINLATFEHALLRVTADDILKATENFSKVHIIGDGGFGTVYKAALPEGRRVAIKRLHGGHQFQGDREFLAEMETIGKVKHPNLVPLLGYCVCGDERFLIYEYMENGSLEMWLRNRADALEALGWPDRLKICLGSARGLAFLHHGFVPHIIHRDMKSSNILLDENFEPRVSDFGLARIISACETHVSTDIAGTFGYIPPEYGLTMKSTTKGDVYSFGVVMLELLTGRPPTGQEEVQGGGNLVGWVRWMIARGKQNELFDPCLPVSSVWREQMARVLAIARDCTADEPFKRPTMLEVVKGLKMTHGMECGPLVVTVSRDM
Protein: Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen homolog) (Q8BWY9)
Organism: Mus musculus (Mouse)
Function: Promotes anchorage-independent cell growth and tumor formation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8TCG1}. Chromosome {ECO:0000250|UniProtKB:Q8TCG1}. Note=Predominantly localizes within the cytoplasm. Localizes to broken chromosomes within micronuclei during interphase and following chromothripsis. Localization to broken chromosomes is mainly independent of MDC1. {ECO:0000250|UniProtKB:Q8TCG1}.
Interaction partners:
- Myc proto-oncogene protein
Sequence:
MDSTACLKSLLLSISQYKAVKSEANATQLLRHLEVVSGQKLTRLFTSHQILPSECLSCLVELLEDPNISASLILSIISLLSQLAIDNETRDCLQNIYNLNSVLSGVVCRSSACHNDSVFLQCIQLLQRLTYNAKFFHSGAHIDDLITFLIGHVQSSEDELTMPCLGLLANLCRHNLSVQTQIKTLSNVKSFYRTLISFLAHSSLTVVVFALSILSSLTLNEEVGEKLFHARNIHQTFQLIFNILINGDGTLTRKYSVDLLMDLLKNPKIADYLTRYEHFSSCLSQVLGLLNAKDPDSSSKVLELLLAFCAVTQLRHVLSQMMFEQSPSGNILGSRPKSLEPTAALLRWLSQPLDGAENCSVLALELFKEIFEDVIDTGNCSSTDHFVTLLLPTILDQLQFKEQNLDETLVRNKCERMVKAIEVLLTLCGDDSLKMHVVKILTTLKCTTLIEQQFTYGKIDLGFGTKVADSELCKLAADVILKTLTLMNKLKQLVPGMEVSFYKILQDPRLITPLAFALTSDNREQVQSGLGILLEASPLPDFPAFVLGESIAANNVYRQQETEHLPRKMTFQPLNHGFSTSAKCLTPPPSKDNAPALNIEDLIEKLQAGVMVKDQISDIRISDIMDVYEMKLSTLASKESRLQDLLEAKALALAQADRLIAQYRCQRTQAETEARTLAGMLREVERKNEELSVLLKSQQLESERAQNDIEHLFQHSKKLESVAAEHEILTKSYMELVQRNEATEKKNTDLQTTCESLNKHIETMKKLNEALKQQNEKTIAQLIEKEEQRKEVQSQLADRECKLSNLHKIAKSQEEKLNVLQKEKEDKQETIDILRKELSRTEQIRKELSIKASSLEMHKAQLEGRLEEKESLLKLQQEELNKHSHMIAMIHSLSGGKISPETVNLSI
Protein: Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha) (P16446)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P53810}. Nucleus {ECO:0000250|UniProtKB:P53810}.
Interaction partners:
- Membrane-associated phosphatidylinositol transfer protein 3
Sequence:
MVLLKEYRVILPVSVDEYQVGQLYSVAEASKNETGGGEGVEVLVNEPYEKDDGEKGQYTHKIYHLQSKVPTFVRMLAPEGALNIHEKAWNAYPYCRTVITNEYMKEDFLIKIETWHKPDLGTQENVHKLEPEAWKHVEAIYIDIADRSQVLSKDYKAEEDPAKFKSIKTGRGPLGPNWKQELVNQKDCPYMCAYKLVTVKFKWWGLQNKVENFIHKQEKRLFTNFHRQLFCWLDKWVDLTMDDIRRMEEETKRQLDEMRQKDPVKGMTADD
Protein: Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) (Q9UPU9)
Organism: Homo sapiens (Human)
Function: Acts as a translational repressor of SRE-containing messengers.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16221671}. Cell projection, dendrite {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptoneurosomes (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1. {ECO:0000250}.
Interaction partners:
- Double-stranded RNA-binding protein Staufen homolog 1
- Nucleolysin TIAR
- Cytotoxic granule associated RNA binding protein TIA1
- Protein Smaug homolog 2
Sequence:
MMFRDQVGVLAGWFKGWNECEQTVALLSLLKRVSQTQARFLQLCLEHSLADCAELHVLEREANSPGIINQWQQESKDKVISLLLTHLPLLKPGNLDAKVEYMKLLPKILAHSIEHNQHIEESRQLLSYALIHPATSLEDRSALAMWLNHLEDRTSTSFGGQNRGRSDSVDYGQTHYYHQRQNSDDKLNGWQNSRDSGICINASNWQDKSMGCENGHVPLYSSSSVPTTINTIGTSTSTILSGQAHHSPLKRSVSLTPPMNVPNQPLGHGWMSHEDLRARGPQCLPSDHAPLSPQSSVASSGSGGSEHLEDQTTARNTFQEEGSGMKDVPAWLKSLRLHKYAALFSQMTYEEMMALTECQLEAQNVTKGARHKIVISIQKLKERQNLLKSLERDIIEGGSLRIPLQELHQMILTPIKAYSSPSTTPEARRREPQAPRQPSLMGPESQSPDCKDGAAATGATATPSAGASGGLQPHQLSSCDGELAVAPLPEGDLPGQFTRVMGKVCTQLLVSRPDEENISSYLQLIDKCLIHEAFTETQKKRLLSWKQQVQKLFRSFPRKTLLDISGYRQQRNRGFGQSNSLPTAGSVGGGMGRRNPRQYQIPSRNVPSARLGLLGTSGFVSSNQRNTTATPTIMKQGRQNLWFANPGGSNSMPSRTHSSVQRTRSLPVHTSPQNMLMFQQPEFQLPVTEPDINNRLESLCLSMTEHALGDGVDRTSTI
Protein: Protein DETOXIFICATION 50 (AtDTX50) (DETOXIFICATION EFFLUX CARRIER 50) (Multidrug and toxic compound extrusion protein 50) (MATE protein 50) (Protein ABNORMAL SHOOT 3-like 1) (Q9FJ87)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as a multidrug and toxin extrusion transporter in the export of abscisic acid (ABA) in guard cells. Plays a role in ABA-mediated growth inhibition and responses to drought conditions. May act as a negative regulator of hypocotyl cell elongation in the light.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24851876}; Multi-pass membrane protein {ECO:0000269|PubMed:24851876}. Late endosome membrane {ECO:0000269|PubMed:26160579}; Multi-pass membrane protein {ECO:0000269|PubMed:26160579}.
Interaction partners:
- ABC transporter G family member 25
- Protein NRT1/ PTR FAMILY 4.6
- ABC transporter G family member 40
- ABC transporter G family member 30
- ABC transporter G family member 31
- ABC transporter G family member 22
- Pyridoxal phosphate
- TraB family protein
- Protein DETOXIFICATION 43
- U-box domain-containing protein 6
Sequence:
MSQSNRVRDEVTLPLLQKTSHLKNHSSVLSVFLNEAISICKISYPLVLTGLFLYVRSFVSLSFLGGLGDATLAGGSLAAAFANITGYSLFSGLTMGVESICSQAFGARRYNYVCASVKRGIILLLVTSLPVTLLWMNMEKILLILKQDKKLASEAHIFLLYSVPDLVAQSFLHPLRVYLRTQSKTLPLSICTVIASFLHLPITFFLVSYLGLGIKGIALSGVVSNFNLVAFLFLYICFFEDKLSVNEDEKITEETCEDSVREWKKLLCLAIPSCISVCLEWWCYEIMILLCGFLLDPKASVASMGILIQITSLVYIFPHSLSLGVSTRVGNELGSNQPKRARRAAIVGLGLSIALGFTAFAFTVSVRNTWAMFFTDDKEIMKLTAMALPIVGLCELGNCPQTTGCGVLRGSARPKIGANINGVAFYAVGIPVGAVLAFWFGFGFKGLWLGMLAAQITCVIGMMAATCRTDWELEAERAKVLTTAVDCGSSDDDAKEDMEAGMVDK
Protein: MIP21537p (D5SHT6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein suppressor of white apricot
Sequence:
MCSISQLQWIHNRLSIGAQNKEPMDVRIDMPWGYVVGKWYGNRQVRPILALHGWLDNLGTWDKLLPLLPKHLGVLCIDLPGHGYSSKLPEGIAYHFVDYLCVILRVMEEYRWQKVSLMAHSMSAMLCFVFASLYPHRTDMLVSIDIVKTRYRKPPSQIDYLRKNIEGYIVEDERFANSKRQEPPAYTYTEMEQVLYKGTDYSVELENCRHILERNISRSTKFPAKFFFSRDGRCKYYTEFHTSPPFAAELARTIKNVPYCVIKGSESNYIDEQSDEVIGILRENNPHFELHEVQGTHHVHLNNAQGVAAVINPFILHHRPPHLENWTVDGTDETLPEVVKEFKLAVEDSENVKRRKRKSNL
Protein: Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) (Q99P50)
Organism: Mus musculus (Mouse)
Function: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Appetite-regulating hormone
- Guanine nucleotide-binding protein G
- Membrane-bound ghrelin O-acyltransferase MBOAT4
- Somatostatin
- Guanine nucleotide-binding protein subunit alpha-11
- Pro-neuropeptide Y
- Melanocortin receptor 3
- Somatoliberin
- Agouti-related protein
- Guanine nucleotide-binding protein G
Sequence:
MWNATPSEEPEPNVTLDLDWDASPGNDSLSDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGSSLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
Protein: Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) (Q9NRZ9)
Organism: Homo sapiens (Human)
Function: Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Note=Closely associated with pericentric heterochromatin. {ECO:0000250}.
Interaction partners:
- WD repeat-containing protein 76
- DNA
- Cell division cycle-associated protein 7
- ATPase family AAA domain-containing protein 2
- Cell division control protein 6 homolog
- DNA repair protein RAD51 homolog 1
- DNA
- Histone deacetylase 1
- Exonuclease 1
- E3 ubiquitin-protein ligase UHRF1
Sequence:
MPAERPAGSGGSEAPAMVEQLDTAVITPAMLEEEEQLEAAGLERERKMLEKARMSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLERKKESLKVKKGKNSIDASEEKPVMRKKRGREDESYNISEVMSKEEILSVAKKNKKENEDENSSSTNLCVEDLQKNKDSNSIIKDRLSETVRQNTKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPDIPTMLYHGTQEERQKLVRNIYKRKGTLQIHPVVITSFEIAMRDRNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLSKKQEIFYTAIVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKIDDFPNELEKLISQIQPEVDRERAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLLFSQMTSMLDILMDYCHLRDFNFSRLDGSMSYSEREKNMHSFNTDPEVFIFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLNLSKNFLDPKELMELLKSRDYEREIKGSREKVISDKDLELLLDRSDLIDQMNASGPIKEKMGIFKILENSEDSSPECLF
Protein: Protein YfdO (P0AD35)
Organism: Escherichia coli (strain K12)
Interaction partners:
Sequence:
MTCAQWLWKKIIALYEQAAECDGEVVRPKEPNWTAWANEIRLMCVQDGRTHKQICEMYSRVSRDPFWCRNVLSPSKLREKWDELSLRLSPSVSTYTEKREDPYFKASYDNVDYSQIPAGFRG
Protein: ATP-dependent RNA helicase glh-4 (EC 3.6.4.13) (Germline helicase 4) (O76743)
Organism: Caenorhabditis elegans
Function: Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development.
Interaction partners:
- Guanyl-specific ribonuclease pgl-3
- Guanyl-specific ribonuclease pgl-1
- P-granule-associated protein deps-1
- Uncharacterized protein
- ATP-dependent RNA helicase glh-1
- Piwi-like protein 1
- Argonaute protein wago-1
- J domain-containing protein
Sequence:
MSFSDDGWGAEAEVKVAEDVPEKNVPPPVEPPRAPQSTAIKTEPERNSDEPSAGFGIDPITTSKTFGSQTTPKTEFGGAPSLSGFGGNAAAAAANKTSFDQQGNGFGGAAKHGFGGVGGAPSSFGANVIPVNKPSLGHKTTGFGGEPKHVSGGAFSSANNFDQQDKGFGGAASSGFGNGSMLTNQKVGLENQTTGVGASEVPTSKPSSFGQQPAVVSGFGGAAKMGFGGSSSSGFGGQKAGATESSGFPTKETSTSQPGFGGDSSTGFGSGLKAGFGGHGAGAAENSGLPTETTGFGGKLPSAGFGASSSNESAFGQQSKGFGGATKNGFGGDSSSSFGSGSKAGFGGTSSSGIGGQKPGATESSGFPTKETSTSGGTFGSGFGGKPTSTGFGAPSTTDSSSGQQTAGFGGASKPGFGGDSSTGFGSGLKAGFGGHRASTAENSGLPTETTGFGGKLPPAGFGASSSNESAFGQQSKGFGGATKNGFGGDSSNSFGKRDSGFGGPQDQGFGDTDAPSKSGLGSFNTGGGAVKSAFGAAGFGSSSNFGNGNTFGEPSDNQRGNWDGGERPRGCHNCGEEGHISKECDKPKVPRFPCRNCEQLGHFASDCDQPRVPRGPCRNCGIEGHFAVDCDQPKVPRGPCRNCGQEGHFAKDCQNERVRMEPTEPCRRCAEEGHWGYECPTRPKDLQGNFLESYDFVFTPDDKMFEDAVNNDDKIDFDQKVVASTGKVEIPDMASFDGFKILPQDLHDNLKRMKMNRPTPIQRASFFPIMHGNDVVACAHTGSGKTLAFLIPFVIKLMEEFEKDRDVTDEKPSPRLLIVAPTRELVNQTFTTARQLTYETGLKCGLAFGGYSRNANVQHLRSFSQLNILVATMGRLQDFVNAGEVSLSKMKYIVLDEADRMVDSNDFGEEVSKIIGSPGERTQQTVLFSASFSEDLQSDDLPKFVKEGYTMLQVDKFGTANEKIDQKILPVPRTEKRDAIYKLLGIDENTVTLLPDAPIEKQKTLIFVNSVKFCDTLAALISSAGVSTISMHSYQNQEQRDRTLDDFRRGKYQCMVASNVCARGLNIAGLDHVVNYDMPDKNGFDEYVNRIGRTGRAGFTGTSTAFVDVENDTDIIPCLVSILNEAKKEVPEWLTEGAGHQEEGGDDWNEQEQEW
Protein: Hexosyltransferase (EC 2.4.1.-) (A1Z8R6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}.
Interaction partners:
- Hexosyltransferase
- Hexosyltransferase
- Beta-1,4-galactosyltransferase 7
- EG:100G10.5 protein
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Xylosyltransferase oxt
Sequence:
MDRRWNPEKIEEQSSLLAAEYSSSSGAAASGSEDETVTTSGALRSKAKLRKRQLRNRMPLPRMLRRLGCYTLSAFLICGLLLVYLPLVYLDVHKRSAGLPDWTSETSRSIADYLDIGLSSGVIVPKDFCRNKTFLVIAVCTGVDNFIQRHTIRETWGNTTEFNYPAFGKLHGHLKGHYLPPLPDRLKMYGDYLSGEGQSLTASVRIVFIVGRQKDEAMLGNETLNRIHIESEKYNDIIQENFVDSYNNLTLKSVMALKHISRSCFNTAVYFLKCDDDTFVNIPNLLNFLLGGTIPLYNDTLDYHDRSTYLVTAPQTRLKASSDVLYGHQFCNVVPVSEVSSKWYMPSYMYKPESYPKYLSGAGYLMSIDVVQRLFEASLNTTLVYLEDVYITGLCAQKAKINRHHHPLFSFAHSKQMCAFKGTITQHQLKDDSMVSAWNYVSNYSIKCPPPGRYFSQVRLRKRPIC
Protein: Isthmin-1 (A2ATD1)
Organism: Mus musculus (Mouse)
Function: Acts as an angiogenesis inhibitor.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Serine palmitoyltransferase 1
Sequence:
MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY
Protein: LD45254p (Uncharacterized protein, isoform A) (Q9V9U3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein CDV3 homolog
- Ccp84Ae
- UPF0184 protein CG14818
- Kazal-like domain-containing protein
- Putative SERF-like protein
- Protein Notchless
- Ribosome biogenesis protein WDR12 homolog
Sequence:
MSEATVAQKPEAVEDVNASTGDEKQTPKRTPKRRSFIERAQKESEELVRTMGGSLELAGGRRTRSSTRGTPTRAAEAVTPPPSKKARTSPASATKASAGKGRGARKLDVGADEPEPELEKEKEKVQTSVKGKGAVKKDKKEVKKQEKATEKYAPEEAKEDVAEAKEEDASPAGVQDQPDGVENLPSVAEAKQNHVDEVKPISEEPGNSSEEVPKAEEPLKSSGETSENGAATETAAAPKEPASVMDVDEDETLVENTPSANKEKALDDEKEPEQKSEEHAAAVLESKEQNEPAKEPTPEPMEVDGSSKGSSDTAQVDTPAIENVSAAPETEAAAKTTESSNDVVEVATEGKETVLEVPAAEPKEAESTVESAEELTETSTVVVTEPKEAASSEEEPSKVVDSAEPKEAESNTDESATPVPIDVSTAPASNDVSKPLEIDTTLVKTADSPAKEPQEICEVKKAEINVNGEPKIVNSSAEVGENAAPKVCN
Protein: 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) (Q5EB55)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
ENNNVNYDWIHWDPENPYKFRHSRPKKPRSLRIYESHVGISSHEGKIASYKHFTSNVLPRIKDLGYNCIQLMAIMEHAYYASFGYQVTSFFAASSRYGTPEELKELVDTAHLMGIVVLLDVVHSHASKNSEDGLNMFDGTDSCYFHSGPRGTHDLWDSRLFIYSSWEVLRFLLSNIRWWLEEYCFDGFRFDGVTSMLYHHHGMGQGFSGDYSEYFGLQVDEDALVYLMLANHLTHTMYPDSITIAEDVSGMPALCSPTSQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGNIVYTLTNRRHLEKCVAYAESHDQALVGDKTLAFWLMDAEMYTNMSVLAPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFNLTDDDLLRYKFLNNFDRDMNRLEETCGWLSAPQAYVSEKHEGNKTITFERAGLLFIFNFHPSKSYTDYRVGTAMPGKFKIVLDSDAAEYGGHQRLDHSTDYFAEAFEHNGRPYSLLVYIPSRVALILQNVDLPN
Protein: Ets variant 6 isoform 1 (A0A0S2Z3C9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004019}.
Interaction partners:
Sequence:
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQIYQEDEC
Protein: Ras-related protein RABA2c (AtRABA2c) (Ras-related protein Rab11A) (AtRab11A) (Q96283)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intracellular vesicle trafficking and protein transport.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18239134}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:18239134}; Lipid-anchor {ECO:0000305|PubMed:18239134}. Note=During cytokinesis located to the growing margins of the cell plate.
Interaction partners:
- Kinesin-like protein KIN-14E
- Trafficking protein particle complex subunit
Sequence:
MTHRVDQEYDYLFKIVLIGDSGVGKSNILSRFTRNEFCLESKSTIGVEFATRTTQVEGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDITKRQTFDNVLRWLRELRDHADSNIVIMMAGNKSDLNHLRSVAEEDGQSLAEKEGLSFLETSALEATNVEKAFQTILGEIYHIISKKALAAQEAAAANSAIPGQGTTINVDDTSGGAKRACCSS