wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome c oxidase subunit NDUFA4 (Q62425)
Organism: Mus musculus (Mouse)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:O00483}; Single-pass membrane protein {ECO:0000250|UniProtKB:O00483}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 6C
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Cytochrome c oxidase subunit 6B1
- Cytochrome c oxidase subunit 5A, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- Cytochrome c oxidase subunit 7A2, mitochondrial
Sequence:
MLRQILGQAKKHPSLIPLFVFIGAGGTGAALYVMRLALFNPDVSWDRKNNPEPWNKLGPNEQYKFYSVNVDYSKLKKEGPDF
Protein: Autophagy-related 14 (LD37690p) (Q9VAP6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Autophagy-related 1, isoform B
- Beclin-1-like protein
- non-specific serine/threonine protein kinase
- Syntaxin 17, isoform B
- UV radiation resistance-associated gene protein
- Autophagy-related protein 13 homolog
- RB1-inducible coiled-coil protein 1
- LD03592p
- phosphatidylinositol 3-kinase
Sequence:
MANSSSSDESCKAPDNFRISSASTNGEDEESDVAGYTTKRRPTAATKELLKDANAKDRNATTGMGAHMRCPLCHSCSASRFHCRNCVRNGNITHSQAERPESLTEKQQRYINLQAGLKTFSTRYERLIGQHRSNEDRLMAIKAKRKQLELLQQLISGTGQRLRVLGERRDELRRANAEKRKNLPKYPDKVKMLENYVLDRVEKIEKLRETHLGLLDSIKQAARRSIQQLVTYVFPIAEVVLKEEQQRRASVERTEEAETIAALADAKNTSYIRGKWVFHGSGISEVQYRIVGPSLPANGDYTAYLDWLADNKDDVPKATANEITPSRFEAYRIVGALTYTAQLTQLLSFYLNVRLPHKIAYGDFCRKLLNEEQFRRKISRLNSNIMYLAYTQQVKLRALIEQHTLENLLAILDLERSDLGRYGHLDVNNAPLMKSVDSLLIGIETATESESEDENSLRMDWEAVPSLTPQPELADPNLMPAANQQSTIAFVRMAATSVLRWIK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A7MB68)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQNSIPFEHHGK
Protein: Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) (Q28165)
Organism: Bos taurus (Bovine)
Function: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (By similarity). Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10688363}. Cytoplasm {ECO:0000269|PubMed:10688363}. Nucleus speckle {ECO:0000269|PubMed:10688363}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism (PubMed:10688363). Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Nucleus; nuclear speckle. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). {ECO:0000250|UniProtKB:Q86U42, ECO:0000269|PubMed:10688363}.
Interaction partners:
- Poly
- Zinc finger C3H1-type containing
- Nuclear cap-binding protein subunit 2
- Serine/arginine-rich splicing factor 1
- Serine/arginine-rich splicing factor 7
- RRM domain-containing protein
- Serine/arginine-rich splicing factor 5
- Serine/arginine-rich splicing factor 3
- Uncharacterized protein.
- polynucleotide adenylyltransferase
Sequence:
MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEELLLEPEPEPEPEEEPPRPRAPPGAPGPGPGSGAPGNQEEEEESGLVEGDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRARATSWYSPY
Protein: Transcriptional regulator LdrP (Cyclic AMP receptor protein/Fumarate and nitrate reduction regulator superfamily protein LdrP) (CRP/FNR superfamily protein LdrP) (Light induced transcription regulator-dependent regulatory protein) (LitR-dependent regulatory protein) (LdrP) (Q746J8)
Organism: Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Function: Activates transcription. Positively regulates PcrtB promoter upstream of the crtB operon in a cAMP-independent manner. Regulated genes include genes encoding DNA photolyase, phytoene synthase and cytochrome P450 monooxygenase, which are involved in carotenoid biosynthesis. Positively regulates the light-inducible gene cluster in the megaplasmid in a cAMP-independent manner.
Interaction partners:
Sequence:
MKRFARKETIYLRGEEARTLYRLEEGLVRVVELLPDGRLITLRHVLPGDYFGEEALEGKAYRYTAEAMTEAVVQGLDPRAMDHEALHRVARNLARQMRRVQAYEAHLQTGELRARIARYLLFLADTPLSARDRQGIYVTVSHEEIADATASIRESVSKVLADLRREGLIATAYRRVYLLDLAALEREAGSALEAA
Protein: Ferritin-2, chloroplastic (EC 1.16.3.1) (Q9SRL5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).
Subcellular location: Plastid, chloroplast {ECO:0000250}.
Interaction partners:
- 1-Cys peroxiredoxin PER1
- CDGSH iron-sulfur domain-containing protein NEET
- Probable metal-nicotianamine transporter YSL4
Sequence:
MLHKASPALSLLSSGYTGGGNLFPPSRNSSNLLFSPSGSRFSVQAAKGTNTKSLTGVVFEPFEEVKKEMELVPTTPFVSLARHKFSDDSESAINDQINVEYNVSYVYHALYAYFDRDNVGLKGFAKFFNDSSLEERGHAEMFMEYQNKRGGRVKLQSILMPVSEFDHEEKGDALHAMELALSLEKLTNEKLLKLQSVGVKNNDVQLVDFVESEFLGEQVEAIKKISEYVAQLRRIGKGHGVWHFDQMLLNDEV
Protein: Transmembrane protein (G5EDR4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSVISDGVISDGVVSDGEVETTTSTILATIVTTVISTLATTQEDHVSTRFPPPRNWTPSNATLKLPRMGNSASAKQVADQVAYGVISCITVGVLIVMLYMSVFGQRVRATAVRWHVLNCSLWGILHLISYASFAEKAPWPNYITNQNWRDTARQVECFTRSVFPAGMVFVYLEQIILTIAPKLANSIVFNAIFFILLIPFLNGLMIFLYYAHFMDIVWWYEPIDLFNLATYLIFTTFTFIYFLFCLFGTCLCCATMTSKKPSSRTTGTFADMWLLFPYGLIPSIMYGPSFGMTSVSFAMQHLLTWVLESGLLTGGGGSSSGGSFIDMNLLMQVATNAILAMPWFVLLFPLVQSILALVCLRMFREQFFFMISCGRIFEGKRAKIGMTEWNVTSIGPPPLYPNSPSEKQEA
Protein: Acyl-CoA dehydrogenase family member 11 (ACAD-11) (EC 1.3.8.-) (Q709F0)
Organism: Homo sapiens (Human)
Function: Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain (Probable).
Subcellular location: Peroxisome {ECO:0000250|UniProtKB:Q80XL6}. Mitochondrion membrane {ECO:0000269|PubMed:21237683}. Note=Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles (PubMed:21237683). No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316. {ECO:0000269|PubMed:21237683}.
Interaction partners:
- UBX domain-containing protein 7
- NSFL1 cofactor p47
- Large subunit GTPase 1 homolog
- Methylthioribose-1-phosphate isomerase
- Hydroxysteroid dehydrogenase-like protein 2
- Enoyl-CoA delta isomerase 2
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Sequence:
MKPGATGESDLAEVLPQHKFDSKSLEAYLNQHLSGFGAEREATLTIAQYRAGKSNPTFYLQKGFQTYVLRKKPPGSLLPKAHQIDREFKVQKALFSIGFPVPKPILYCSDTSVIGTEFYVMEHVQGRIFRDLTIPGLSPAERSAIYVATVETLAQLHSLNIQSLQLEGYGIGAGYCKRQVSTWTKQYQAAAHQDIPAMQQLSEWLMKNLPDNDNEENLIHGDFRLDNIVFHPKECRVIAVLDWELSTIGHPLSDLAHFSLFYFWPRTVPMINQGSYSENSGIPSMEELISIYCRCRGINSILPNWNFFLALSYFKMAGIAQGVYSRYLLGNNSSEDSFLFANIVQPLAETGLQLSKRTFSTVLPQIDTTGQLFVQTRKGQEVLIKVKHFMKQHILPAEKEVTEFYVQNENSVDKWGKPLVIDKLKEMAKVEGLWNLFLPAVSGLSHVDYALIAEETGKCFFAPDVFNCQAPDTGNMEVLHLYGSEEQKKQWLEPLLQGNITSCFCMTEPDVASSDATNIECSIQRDEDSYVINGKKWWSSGAGNPKCKIAIVLGRTQNTSLSRHKQHSMILVPMNTPGVKIIRPLSVFGYTDNFHGGHFEIHFNQVRVPATNLILGEGRGFEISQGRLGPGRIHHCMRTVGLAERALQIMCERATQRIAFKKKLYAHEVVAHWIAESRIAIEKIRLLTLKAAHSMDTLGSAGAKKEIAMIKVAAPRAVSKIVDWAIQVCGGAGVSQDYPLANMYAITRVLRLADGPDEVHLSAIATMELRDQAKRLTAKI
Protein: Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105) (Q92750)
Organism: Homo sapiens (Human)
Function: Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:11567023, ECO:0000269|PubMed:16088961}. Cytoplasm {ECO:0000269|PubMed:11567023, ECO:0000269|PubMed:16088961}. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation. {ECO:0000269|PubMed:11567023}.
Interaction partners:
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 11
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 7-like
- Transcription initiation factor TFIID subunit 8
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 6
Sequence:
MPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSPVGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGTVLIKSNSGPLMLVSPQQTVTRAETTSNITSRPAVPANPQTVKICTVPNSSSQLIKKVAVTPVKKLAQIGTTVVTTVPKPSSVQSVAVPTSVVTVTPGKPLNTVTTLKPSSLGASSTPSNEPNLKAENSAAVQINLSPTMLENVKKCKNFLAMLIKLACSGSQSPEMGQNVKKLVEQLLDAKIEAEEFTRKLYVELKSSPQPHLVPFLKKSVVALRQLLPNSQSFIQQCVQQTSSDMVIATCTTTVTTSPVVTTTVSSSQSEKSIIVSGATAPRTVSVQTLNPLAGPVGAKAGVVTLHSVGPTAATGGTTAGTGLLQTSKPLVTSVANTVTTVSLQPEKPVVSGTAVTLSLPAVTFGETSGAAICLPSVKPVVSSAGTTSDKPVIGTPVQIKLAQPGPVLSQPAGIPQAVQVKQLVVQQPSGGNEKQVTTISHSSTLTIQKCGQKTMPVNTIIPTSQFPPASILKQITLPGNKILSLQASPTQKNRIKENVTSCFRDEDDINDVTSMAGVNLNEENACILATNSELVGTLIQSCKDEPFLFIGALQKRILDIGKKHDITELNSDAVNLISQATQERLRGLLEKLTAIAQHRMTTYKASENYILCSDTRSQLKFLEKLDQLEKQRKDLEEREMLLKAAKSRSNKEDPEQLRLKQKAKELQQLELAQIQHRDANLTALAAIGPRKKRPLESGIEGLKDNLLASGTSSLTATKQLHRPRITRICLRDLIFCMEQEREMKYSRALYLALLK
Protein: Sulfite reductase [ferredoxin] (EC 1.8.7.1) (P9WJ03)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.
Interaction partners:
- Adenosine 5'-phosphosulfate reductase
- Bifunctional enzyme CysN/CysC
- Ferrochelatase Che1
- uroporphyrinogen-III C-methyltransferase
- Cystathionine gamma-synthase
- Probable gamma-glutamyltranspeptidase GgtB
- O-acetylserine sulfhydrylase
- Sulfate adenylyltransferase subunit 2
- O-succinylhomoserine sulfhydrylase
- L-cysteine desulfhydrase Cds1
Sequence:
MTTARPAKARNEGQWALGHREPLNANEELKKAGNPLDVRERIENIYAKQGFDSIDKTDLRGRFRWWGLYTQREQGYDGTWTGDDNIDKLEAKYFMMRVRCDGGALSAAALRTLGQISTEFARDTADISDRQNVQYHWIEVENVPEIWRRLDDVGLQTTEACGDCPRVVLGSPLAGESLDEVLDPTWAIEEIVRRYIGKPDFADLPRKYKTAISGLQDVAHEINDVAFIGVNHPEHGPGLDLWVGGGLSTNPMLAQRVGAWVPLGEVPEVWAAVTSVFRDYGYRRLRAKARLKFLIKDWGIAKFREVLETEYLKRPLIDGPAPEPVKHPIDHVGVQRLKNGLNAVGVAPIAGRVSGTILTAVADLMARAGSDRIRFTPYQKLVILDIPDALLDDLIAGLDALGLQSRPSHWRRNLMACSGIEFCKLSFAETRVRAQHLVPELERRLEDINSQLDVPITVNINGCPNSCARIQIADIGFKGQMIDDGHGGSVEGFQVHLGGHLGLDAGFGRKLRQHKVTSDELGDYIDRVVRNFVKHRSEGERFAQWVIRAEEDDLR
Protein: Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4] (O75487)
Organism: Homo sapiens (Human)
Function: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.; SUBCELLULAR LOCATION: [Secreted glypican-4]: Secreted, extracellular space {ECO:0000250}.
Interaction partners:
- Leucine-rich repeat transmembrane neuronal protein 4
- Frizzled-7
- Frizzled-2
- Frizzled-3
- Frizzled-8
- Frizzled-5
- Frizzled-9
- Frizzled-1
- Frizzled-6
- Frizzled-4
Sequence:
MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKICPQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANEKADSAGVRPGAQAYLLTVFCILFLVMQREWR
Protein: Uncharacterized protein (O34461)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- Epoxyqueuosine reductase QueH
- Purine nucleoside phosphorylase
- Transcriptional regulator
Sequence:
MLLDYDFLLLLNDESGKPTRYYYLLQDFEKDFVAREVAQNKTKRFVKEIIGSEKASKTKNSAIEVSNTKASAMKNETIGSGDLKKVCEKIKSALPFGIISAFKPFKDAFYRDFNHNEQKLLIGAAKSGCIQSSADKLAQLKTRLLYWQDKSVKVDWDKPILIKDFFKGNNYLYRRFCFLLGKHFMDRFLKNNAKASVKDFMSSKEFVAKYRYTPKQNTERAKKLQSYLENKRDFIGFVQALNSLKDNPQDPFLPNEETSFLVFANEPTIVFNLRDYLLVLAQIFNQQAICYCESKCPIELINASPGKDFNKTQDSFPDIKFSTPNQLEQSLNALKNKLAAFFSKHPDKHNGMEFNEIAKTQIEALYMPQSSDGFDDFRKHLEESIKSFIRAKKNRYGFPKIFDVADIEQEERKVIEWREKERASKQSYKQNLQINKIANDLKRDKVVDKRTILSVIDADLDRGFIPPKDLLKQLEKISASLSKDIVIAIKQVEKLELSYALIDNIQHNTLDDTLDFTFIVGDSLSVQSLYVTFDLVIDMDRPMSEQFLNHIGELGSFESRERALEWVRLSQAKLIIETPREALKNAQLSQIEEILTGCIFNGAYRLQNDLKGNRHGNFK
Protein: Transcription factor HNF-4 homolog (dHNF4) (Nuclear receptor subfamily 2 group A member 4) (P49866)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcriptionally controlled transcription factor. Important for the differentiation of various specialized cell types that arise from both endoderm and mesoderm. May have a role in early gut formation. Plays an essential role in lipid catabolism, regulating lipid mobilization and beta-oxidation in response to nutrient deprivation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:19254568}.
Interaction partners:
- LP12374p
- FI18188p1
- Uncharacterized protein, isoform A
- Nuclear hormone receptor HR96
Sequence:
MMKHPQDLSVTDDQQLMKVNKVEKMEQELHDPESESHIMHADALASAYPAASQPHSPIGLALSPNGGGLGLSNSSNQSSENFALCNGNGNAGSAGGGSASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLPLSPPNQSNDYQSPTHTGNMEGGNQVNSSLDSLATSGGPGSHSLDLEVQHIQALIEANSADDSFRAYAASTAAAAAAAVSSSSSAPASVAPASISPPLNSPKSQHQHQQHATHQQQQESSYLDMPVKHYNGSRSGPLPTQHSPQRMHPYQRAVASPVEVSSGGGGLGLRNPADITLNEYNRSEGSSAEELLRRTPLKIRAPEMLTAPAGYGTEPCRMTLKQEPETGY
Protein: Adhesion G protein-coupled receptor L3 isoform X5 (Adhesion G protein-coupled receptor L3.1) (A0A2R8Q6E9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MALTCPRRSFSESVQRSTGSSAVMWSTRLLFFFTLFTPVTLVLSRAPVPMAVVRRELSCEGYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENTRCYLPDAYKIMGFRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGVLRGVYQSEHLFESDHQAGSWCKDPLQSSNKIYYMPWTPYRTDTLTEYSSKEDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGRIVVSQLNPYTLRVEGSWDTSYDKRSASNAFMICGILYVVKSVYEDDDNEALGNKIDYMYNTEKSRETHLSIPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVIYSLDFGNNDNRLGFDPPSSVLLPDPLPPVRSSTTPPRPYTGTLRPSLTTTTTTTMVPPRRHNNVLPEALTRAPPSPQTPVTVDYCAPRLTAEISWPRTHQGQVAKQPCPPGTIGVATFNCLLGYWDPKGPDLSNCTSPWTNHITQRMRSGETAAIVARELAEQTKGELRPGDVPSTVKAMAQLVELLDVQLRNLTPGGKDTAARSLNKLQKRERSCRFFIQAMVETVNNLLQVRSQAAWRELSVAEQLRCATMLLDTVETGAFMLADNLLKTDTIQESTDNIQLEVARLSTDVNLADLSFPQSGLTGNSIHLSANTLKQQGRNGEIRMALVLYKNLGQYLSTENASVRLGSEAVYPNYSLIVNSPVITAAINKDSNKVYLSEPVVFTVKHIQQSEENFNPNCSFWSYSKRTMTGFWSTQDCRLLGTNRTHTSCSCTHLTNFAVLMAHVEVKKADQVHELLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFIAETLFLTGINRADQPIVCAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEYSRTKYFYLTGYGVPAVIVAVSAAVDYRSYGTERVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPDSGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCILQKKVRKEYGRCLRTHCCSGKSVESTISTSTKTSTARTPGRYSTNSQSRIRRMWNDTVRKQSESSFITADMNSSATLNREGILNNARDSSVMDTLPLNGNHGNSYGVAAGDYLTYSSRGSEPPTTLEKKILKELTANYAPSYLNTQERQGKAHQGTLTNKLNNHLANGGVAGSSSIPKDDVMVLDNPGAFHRHDDGGGLSLELIREESQAPLLPPRPPPPENHAPLHTFTAHRRLPQENSESFFPLLPNDTHSSHTHTPRAHTHSPLRDSLYTSMPTLTDLPHGTDDLINGLHDDEDEEEEEDGEEEEGSELHLANGKGVIMESDDVYYKSMPNLGSRNHIQELESYYQMGRGGSDGFIAPPEKEDSSPEEQPPDPSQLVTSL
Protein: Cyclic AMP response element-binding protein B (cAMP response element-binding protein B) (dCREB-B) (Q9VWW0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Isoform E is a PKA-dependent transcriptional activator. Isoform J is a direct antagonist of activation by isoform E in cell culture. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Has a role in long-term memory.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00312, ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:7651429}.
Interaction partners:
- Cyclic AMP response element-binding protein A
- histone acetyltransferase
- Chromosomal serine/threonine-protein kinase JIL-1
- non-specific serine/threonine protein kinase
- RAC serine/threonine-protein kinase
- MAP kinase-activated protein kinase 2
- CREB-regulated transcription coactivator, isoform B
Sequence:
MDNSIVEENGNSSAASGSNDVVDVVAQQAAAAVGGGGGGGGGGGGGNPQQQQQNPQSTTAGGPTGATNNAQGGGVSSVLTTTANCNIQYPIQTLAQHGLQVSIWGPGAWCQLSSVRCYGSQPEVATKDVQSVIQANPSGVIQTAAGTQQQQQALAAATAMQKVVYVAKPPNSTVIHTTPGNAVQVRNKIPPTFPCKIKPEPNTQHPEDSDESLSDDDSQHHRSELTRRPSYNKIFTEISGPDMSGASLPMSDGVLNSQLAGTGAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIAEDQTRKREIRLQKNREAARECRRKKKEYIKCLENRVAVLENQNKALIEELKSLKELYCQTKND
Protein: Cell division protein FtsX (P0AC30)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. Encoded in an operon consisting of genes ftsY, ftsE and ftsX.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:10048040, ECO:0000269|PubMed:14729705, ECO:0000269|PubMed:3323846}; Multi-pass membrane protein {ECO:0000269|PubMed:10048040, ECO:0000269|PubMed:14729705, ECO:0000269|PubMed:3323846}. Note=Localizes to the septal ring at the later stages of cell growth and remains there until division is complete. This localization is dependent on localization of FtsZ, FtsA and ZipA, but not on the downstream division proteins FtsK, FtsQ or FtsI.
Interaction partners:
- Cell division ATP-binding protein FtsE
- Murein hydrolase activator EnvC
- Cell division protein FtsA
- Cell division protein ZipA
- Cell division protein FtsQ
- Cell division protein FtsZ
- DNA translocase FtsK
- Probable peptidoglycan glycosyltransferase FtsW
- Cell division protein FtsL
- Peptidoglycan D,D-transpeptidase FtsI
Sequence:
MNKRDAINHIRQFGGRLDRFRKSVGGSGDGGRNAPKRAKSSPKPVNRKTNVFNEQVRYAFHGALQDLKSKPFATFLTVMVIAISLTLPSVCYMVYKNVNQAATQYYPSPQITVYLQKTLDDDAAAGVVAQLQAEQGVEKVNYLSREDALGEFRNWSGFGGALDMLEENPLPAVAVVIPKLDFQGTESLNTLRDRITQINGIDEVRMDDSWFARLAALTGLVGRVSAMIGVLMVAAVFLVIGNSVRLSIFARRDSINVQKLIGATDGFILRPFLYGGALLGFSGALLSLILSEILVLRLSSAVAEVAQVFGTKFDINGLSFDECLLLLLVCSMIGWVAAWLATVQHLRHFTPE
Protein: Probable G-protein coupled receptor 85 (Super conserved receptor expressed in brain 2) (P60893)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:25780553}.
Interaction partners:
- C-X-C motif chemokine 14
- Insulin-induced gene 2 protein
Sequence:
MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKSRLPREPYCVI
Protein: Terpene synthase 2 (PnTPS2) (Cadinene synthase) (PnCDS) (EC 4.2.3.-) (Cadinol synthase) (PnCO) (EC 4.2.3.-) (A0A1V0E4A6)
Organism: Piper nigrum (Black pepper)
Function: Sesquiterpene synthase involved in the biosynthesis of volatile compounds that contribute to the characteristic flavors of black pepper. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into alpha-cadinene, delta-cadinene and delta-cadinol.
Interaction partners:
Sequence:
MDAVSCAINALSAQAPPKHLGGNNVGRKSVTFPKDIWGDYFLKISPNEEKLDSWRVRAKELKEKVFDILSCAKGAEQVHIIDALYHLGVSYQFEKEIEEALKNMLTTYNDDTSTEDDLYTLALRFRLLRQNGFHASTKALNKFKDAHGSFREDLASDVMGLLSLYEASYAGTVDDLILDEALAFTKIHLKAALPHLDSHLAQRVSHSLELPLHKRIQRLEAREFISLCEKDDSIVIKELLEFAKLDYNILQALHQWELKELTKWWKKLNLVGKMTFARDRMTEIYFYVSGFFFEPQYSRGRIISSKILAICSVVDDEYDVYGTLDELQVFTDAICRLDVAAMENLPEYVKPLYEAIFFSLKEFEEELAREGNAYRVNYLREEVKNLCKSYLQETKWLHQRYIPTLEEYLLVSEISSTYTVIFNGCFVGCGEIATKEVFEWFQAFPKLLSDSARIGRIADDIMSCKFEQSRGHCPSAVECCMEEHQCTKEVALGNLDGVLGRAWKDMNKACMRPTPFPMEVLRPIVNLARMAEISYQYEDGYTFSGGKTKERISMLYKDPIPV