wanglab/gogpt-training-data huggingface dataset:
Protein: Disheveled-associated activator of morphogenesis 1 isoform X2 (Dishevelled-associated activator of morphogenesis 1a) (A0A0R4IER9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MMAPRKRGGRGLSFLCCCLKGSDHPEITYSLRHGSNFTLQTMEPTLPMPPTEELDAMFTELVDELDLTEKHRAAMFALPAEKKWQIYCSKKKEQEENKGATSWPEFYIDQINSMAARKSLLALEKEDEEERNKTIESLKTALRTQPMRFVTRFIDQDGLTCILNFLKTMDYETTESQIHTSLIGCIKALMNNSQGRAHVLSHSESINIIAQSLATENIKTKVAVLEIMGAVCLVPGGHKKILEAMLHYQKFACERTRFQTLLNDLDRSTGRYRDEVNLKTAIMSFINAVLSQGAGETSLEFRIHLRYEFLMLGIQPVIDKLRSHENSTLDRHLDFFEMLRNEDELALAKRFENVHVDTKSATQMFELIRKRINHTDAFPHFISVLQHCLHMPYKKTGNTVQYWVLLDRIVQQIILQNDKGLDPDVAPLENFDVKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKAQEKEEMMQTLNKMKEKLEKESSEHKLVKQQVADLSARLHEMSNRTNIPGGPPLAPLGPGLPPPPPPPGQAGLPPPPPPGGAPPPPPPPPGGPPPPPGLLGFGAPPPPGGLLGSTLKKKNIPQPSNPLKSFNWTKLSENKLEGTVWLDLDDVRVFKQLDLEDIEKTFSAYQRQQKESEDDTVTSKKVKELSVIDGRRAQNCNILLSKLKLSNEEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDVDLLEEHKHELERMAKADRFLYEMSRINHYQQRLQSLYFKKKFAERIAEIKPKVEALSKASKEVLQSKNLRQLLEIVLAFGNYMNKGQRGNAYGFKVSSLNKIADTKSSIDKNVTLLHYLITVLEQKYPKVSLIHEDLQNVPVAAKVNMTELEKDINNLRSGLKSVETELEYQRTQPQTYGDKFVSVVSQFITVAGFSFSDIEDSLQDAKDSFGKAVQHFGEDATRMQPDEFFGIFDQFLQGFSEAKQDNENMRRRKEEEERRARMEAQLKEQRERERKSRKAKENCEEDGEFDDLVSALRSGEVFDKDMSKMKHNRKRPVKSSAESSRERPVTKLNF
Protein: N-alpha-acetyltransferase 60 (dNaa60) (EC 2.3.1.259) (EC 2.3.1.48) (NatF catalytic subunit) (Q95SX8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase.
Interaction partners:
- N
- N-alpha-acetyltransferase 40
- GEO02452p1
- N-terminal amino-acid N
- N-alpha-acetyltransferase 80
- GEO07882p1
Sequence:
MAQFTLYNKHSAPPSSESTRVDCEHVPLCSINDVQLRFLVPDDLTEVRQLCQEWFPIDYPLSWYEDITSSTRFFALAAVYNLAIIGLIVAEIKPYRNVNKEVIANMSDSDELYTRLSGFPMQDKGILPDSMGRSADVGYILSLGVHRSHRRNGIGSLLLDALMNHLTTAERHSVKAIFLHTLTTNQPAIFFYEKRRFTLHSFLPYYYNIRGKGKDGFTYVNYINGGHPPWTLLDHIKHYASMVRHTSSLCAWLAGRVQQVVRWFYHKLLTRFNFIE
Protein: BTB/POZ domain-containing protein 7 (Function-unkown protein 1) (Q8CFE5)
Organism: Mus musculus (Mouse)
Function: Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression.
Subcellular location: Nucleus {ECO:0000269|PubMed:11527404}.
Interaction partners:
Sequence:
MGANASNYPHSCSPRVGGNSQAQQTFIGTSSYSQQGYGCESKLYSLDHGHEKPQDKKKRTSGLATLKKKFIKRRKSNRSADHAKQMRELLSGWDVRDVNALVEEYEGTSALKELSLQASLARPEARTLQKDMADLYEDKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDISTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDILVQLSEEFGTPNPLDVDMRGLFDYMCYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAIISARSPFFRNLLQRRIRTGEEITDRTLRTPTRIILDESIIPKKYAKVILHCMYTDVVDLSVLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQGCEDIIAESISLDTLIAVLKWSSHPYGSKWVHRQAVHFLCEELSQVMTSDVFYELSKDHLLTAIQSDYLQASEQDILKYLIKWGEHQLMKRIADREPNLLSGTAHSVNKRGVKRRDLDIEELREILSSLLPFVRIEHILPINSEVLSDAMKRGLISTPPSDMLPTAEGGKSNAWLRQKNAGIYVRPRLFSPYVEEAKSVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVSNAMPQCCHMISHQQISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERFGDESPLLTMRQPGRCRVNSTPTAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSHHPSRSFSYPCNHSLFHCRTAPKPGPPPVYLPGVKVAPPDCTNTTGLGRQTVAAAAAAAAASAAIIPEKQVCPQPVLNDLMPDIAMGVSTLSLKDRRLPELAADTELCQTVSEAGTGPPQHLSCIPQRHTNTSRKKPTLEQKADGRENQQEYPDLYDFSNAACRPSTPAPGRHSPSPAHGRYFGPDLYSHNKASPNGLKSVYLPGQTSPKKQEDPRREYPPSPDGHPHRQKREPIRLDVVEQPPQRPDFPSAASENASHGPAHVRARTAVETDLTFGLTSNRPPSHSACSSEVLEERSSRRLTDSEPLGHGAHQRNADLERGDSISRGRRSPSKPDFLYKKSAL
Protein: Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r) (P06899)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H2A type 1-B/E
- Histone H4
- Histone H3.1
- Histone H2A type 1
- Histone H2A type 1-C
- Histone H3.2
- Histone H3.1t
- Histone H3.3
- Histone H2A.Z
- Histone H2AX
Sequence:
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK
Protein: C-C motif chemokine 4 (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Small-inducible cytokine A4) (P50230)
Organism: Rattus norvegicus (Rat)
Function: Monokine with inflammatory and chemokinetic properties.
Subcellular location: Secreted.
Interaction partners:
- C-C chemokine receptor type 5
- Macrophage inflammatory protein-1 alpha receptor
- C-C chemokine receptor type 3
- C-X-C chemokine receptor type 3
- C-C motif chemokine 3
- C-X-C chemokine receptor type 4
- C-C motif chemokine receptor 7
- C-C motif chemokine 5
- C-X-C chemokine receptor type 2
- C-C motif chemokine receptor 8
Sequence:
MKLCVSAFSLLLLVAAFCDSVLSAPIGSDPPTSCCFSYTSRKIHRNFVMDYYETSSLCSQPAVVFLTKKGRQICADPSEPWVNEYVNDLELN
Protein: ADP-ribosylation factor-like protein alp41 (Altered polarity protein 41) (Q09767)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in the cofactor-dependent pathway of microtubule biogenesis. Required for growth polarity control.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Tubulin-folding cofactor D
- Cell polarity protein alp21
- Cytochrome b-c1 complex subunit 10
- Tubulin-specific chaperone C
- Cell polarity protein alp11
- N-acetyltransferase ats1
- D-aminoacyl-tRNA deacylase
- Probable tubulin--tyrosine ligase C12B10.04
- Eukaryotic translation initiation factor 3 subunit G
Sequence:
MGLLTILRQQKLKEREVRVLLLGLDNAGKTTILKCLLNEDVNEVSPTFGFQIRTLEVEGLRFTIWDIGGQKTLRNFWKNYFESTEAIIWVVDSLDDLRLEECRNTLQELLVEEKLLFTSILVLANKSDVSGALSSEEISKILNISKYKSSHWRIFSVSALTGLNIKDAISWLANDLKEIKLGTIDY
Protein: Zinc finger protein 14 homolog (Zfp-14) (Zinc finger protein 531) (Q9HCL3)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MAHGSVTFRDVAIDFSQEEWEFLDPAQRDLYRDVMWENYSNFISLGPSISKPDVITLLDEERKEPGMVVREGTRRYCPDLESRYRTNTLSPEKDIYEIYSFQWDIMERIKSYSLQGSIFRNDWECKSKIEGEKEQQEGYFGQVKITSEKMTTYKRHNFLTEYQIVHNGEKVYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKECGKAFTVLQELTQHQRLHTGEKPYECKECGKAFRVHQQLARHQRIHTGEKPYECKDCGKTFRQCTHLTRHQRLHTAEKLYECKECGKAFVCGPDLRVHQKIHFGEKPYECKECGKAFRICQQLTVHQSIHTGEKPYECKECGKTFRLRQQLVRHQRIHTREKPYECMECWKTFSSYSQLISHQSIHIGERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECKECRKPFRLLSQLTQHQSIHTGEKPYECKECGKAFRLYSFLTQHQRIHTGEKPYKCKECKKAFRQHSHLTQHQKIHNGI
Protein: E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1) (Q96FA3)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3. Negatively regulates necroptosis by reducing RIPK3 expression. Mediates 'Lys-63'-linked ubiquitination of RIPK1.
Subcellular location: Chromosome {ECO:0000269|PubMed:17997719}. Note=Localizes to DNA double-strand breaks (DSBs) in response to DNA damage. {ECO:0000269|PubMed:17997719}.
Interaction partners:
- Interleukin-1 receptor-associated kinase 1
- Interleukin-1 receptor-associated kinase 4
- TNF receptor-associated factor 6
- Receptor-interacting serine/threonine-protein kinase 1
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Receptor-interacting serine/threonine-protein kinase 3
- Ubiquitin conjugating enzyme E2 V1
- Mothers against decapentaplegic homolog 6
- Ubiquitin-conjugating enzyme E2 N
- Serine/threonine-protein kinase TBK1
Sequence:
MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD
Protein: Pre-tRNA-processing protein PTA1 (Q01329)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential in pre-tRNA processing. Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:12819204}.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-2
- mRNA 3'-end-processing protein RNA14
- mRNA 3'-end-processing protein YTH1
- Protein SYC1
- Protein PCF11
- Pre-mRNA polyadenylation factor FIP1
- RNA end formation protein 2
- Protein CFT1
- mRNA 3'-end-processing protein RNA15
- Endoribonuclease YSH1
Sequence:
MSSAEMEQLLQAKTLAMHNNPTEMLPKVLETTASMYHNGNLSKLKLPLAKFFTQLVLDVVSMDSPIANTERPFIAAQYLPLLLAMAQSTADVLVYKNIVLIMCASYPLVLDLVAKTSNQEMFDQLCMLKKFVLSHWRTAYPLRATVDDETDVEQWLAQIDQNIGVKLATIKFISEVVLSQTKSPSGNEINSSTIPDNHPVLNKPALESEAKRLLDMLLNYLIEEQYMVSSVFIGIINSLSFVIKRRPQTTIRILSGLLRFNVDAKFPLEGKSDLNYKLSKRFVERAYKNFVQFGLKNQIITKSLSSGSGSSIYSKLTKISQTLHVIGEETKSKGILNFDPSKGNSKKTLSRQDKLKYISLWKRQLSALLSTLGVSTKTPTPVSAPATGSSTENMLDQLKILQKYTLNKASHQGNTFFNNSPKPISNTYSSVYSLMNSSNSNQDVTQLPNDILIKLSTEAILQMDSTKLITGLSIVASRYTDLMNTYINSVPSSSSSKRKSDDDDDGNDNEEVGNDGPTANSKKIKMETEPLAEEPEEPEDDDRMQKMLQEEESAQEISGDANKSTSAIKEIAPPFEPDSLTQDEKLKYLSKLTKKLFELSGRQDTTRAKSSSSSSILLDDDDSSSWLHVLIRLVTRGIEAQEASDLIREELLGFFIQDFEQRVSLIIEWLNEEWFFQTSLHQDPSNYKKWSLRVLESLGPFLENKHRRFFIRLMSELPSLQSDHLEALKPICLDPARSSLGFQTLKFLIMFRPPVQDTVRDLLHQLKQEDEGLHKQCDSLLDRLK
Protein: Prefoldin subunit 3 (Gene involved in microtubule biogenesis 2) (P57741)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Together with other chaperonins, contribute to the regulation of gene expression by modulating the spliceosome function on pre-mRNA splicing post-transcriptionally by acting as a co-chaperone of Hsp90 to control levels of LSM8 (By similarity). Required for the biogenesis of tubulins and for subsequent microtubules (MTs) organization and dynamicity. Necessary for tolerance to NaCl salt stress. Involved in the process leading to microtubules dissociation in response to gibberellic acid (GA) probably due to the DELLA proteins-mediated translocation of the prefoldin co-chaperone complex from the cytoplasm to the nucleus (By similarity). Prevents cold acclimation (e.g. 7 days at 4 degrees Celsius) in a DELLA proteins-dependent manner by promoting nuclear proteasome-mediated HY5 degradation, thus modulating the expression of several genes and reducing anthocyanin biosynthesis, but seems not involved in constitutive freezing tolerance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28412546}. Nucleus {ECO:0000269|PubMed:28412546}. Note=In the presence of gibberellic acid (GA) and at room temperature, the prefoldin complex stays in the cytoplasm and is functional (PubMed:28412546). But in the absence of GA or in response to cold, the prefoldin complex is localized to the nucleus in the presence of DELLA proteins, which severely compromises alpha/beta-tubulin heterodimer availability, thus affecting microtubules (MTs) organization (PubMed:28412546). This changing subcellular localization follows a daily rhythm coordinated oscillation (By similarity). {ECO:0000250|UniProtKB:P57742, ECO:0000269|PubMed:28412546}.
Interaction partners:
- Prefoldin subunit 6
- Prefoldin subunit 2
- Prefoldin subunit 4
- Prefoldin subunit 1
- Prefoldin subunit 5
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit alpha
- At1g49245
Sequence:
MSSSSPSGSGSDLTERRGIPAAKFIQDVETYLSQSGLDPNSALAFHQERLQQYKVVEMKLLAQQRDLQAKIPDIEKCLEVVATLEAKKGTGEALLADFEVSEGIYSRACIEDTDSVCLWLGANVMLEYSCEEASALLKNNLENAKASLEVLVADLQFLRDQVTVTQVTIARVYNWDVHQRRVKQVTPTAIAVADS
Protein: 2'-5' oligoadenylate synthase (EC 2.7.7.84) (Q91YM7)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
GCQAGEHAACFAELRRNFINTCPPKLKSLMLLVKHWYRQVVTQYKGGEAAGDAPPPAYALELLTIFAWEQGCGEQKFSLAEGLQTILRLIQQHQSLCIYWTVNYSVQDPAIRAHLLCQLRKARPLVLDPADPTWNVGQGDWKLLAQEAAALGSQVCLQSGDGTLVPPWDVTPALLHQTLAEDLDKFISEFLQPNRHFLTQVKRAVDTICSFLKENCFRNSTIKVLKVVKGGSSAKGTALQGRSDADLVVFLSCFRQFSEQGSHRAEIISEIQAQLEACQQTHSFDVKFEVSKRKNPRVLSFTLTSQTLLDQSVDFDVLPAFDALGQLRSGSRPDPRVYTDLIHSCSNAGEFSTCFTELQRDFITSRPTKLKSLIRLVKYWYQQCNKTIKGKGSLPPQHGLELLTVYAWEQGGQNPQFNLAEGFRTVLELIVQYRQLCVYWTINYSAEDKTIGDFLKMQLRKPRPVILDPADPTGNLGHNARWDLLAKEATVYASALCCVDRDGNPIKPWPVKAAV
Protein: Melanoma-associated antigen B4 (MAGE-B4 antigen) (O15481)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A2A9R3}.
Interaction partners:
Sequence:
MPRGQKSKLRAREKRQRTRGQTQDLKVGQPTAAEKEESPSSSSSVLRDTASSSLAFGIPQEPQREPPTTSAAAAMSCTGSDKGDESQDEENASSSQASTSTERSLKDSLTRKTKMLVQFLLYKYKMKEPTTKAEMLKIISKKYKEHFPEIFRKVSQRTELVFGLALKEVNPTTHSYILVSMLGPNDGNQSSAWTLPRNGLLMPLLSVIFLNGNCAREEEIWEFLNMLGIYDGKRHLIFGEPRKLITQDLVQEKYLEYQQVPNSDPPRYQFLWGPRAHAETSKMKVLEFLAKVNDTTPNNFPLLYEEALRDEEERAGARPRVAARRGTTAMTSAYSRATSSSSSQPM
Protein: Cysteine synthase 1 (CS 1) (EC 2.5.1.-) (EC 2.5.1.47) (O-acetylserine (thiol)-lyase 1) (OAS-TL 1) (O-acetylserine sulfhydrylase 1) (O-succinylserine sulfhydrylase) (O59701)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14981292}.
Interaction partners:
- Homocysteine synthase
- Sulfite reductase subunit beta
- Cystathionine beta-lyase
- Probable cystathionine gamma-synthase
- Sulfide:quinone oxidoreductase, mitochondrial
- Putative serine acetyltransferase
- Probable sulfite reductase flavoprotein component
- Adenosylhomocysteinase
- Putative phosphoserine aminotransferase
- Glutamate--cysteine ligase
Sequence:
MATSGIQTKVPGIVSGFIGAIGRTPLIRLNTLSNETGCNILAKAEFQNPGGSVKDRAAYYVVRDAEKKGKLSRGGTIVEGTAGNTGIGLAHIARARGYKCVIYMPNTQSQAKIDTLKFLGAEVHPVPVAPFSNPLNYNHQARRHAESTPNASWTDQFDNVANLLSHYETTGPEIWDQTKGTVDGFTCSTGTGGTFAGVTKYLKEKSDGRVASFVADPPGSVLYSHIKTKGKHPDNKGSSFTEGIGQGRITGNVQPVYDLIDDAMKIPDEKSINMFFRLLDQEGLFLGGSSCLNVVAAVEMAKILGPGKTVVTILCDSGHKYATRLFSRSFLESKKLFDVIEPQYKKYIVLP
Protein: Aquaporin PIP1-2 (Plasma membrane intrinsic protein 1-2) (ZmPIP1-2) (ZmPIP1;2) (ZmPIP1b) (Q9XF59)
Organism: Zea mays (Maize)
Function: Water channel required to facilitate the transport of water across cell membrane. Active as heteromers with PIP1-1, PIP2-1, PIP2-4 or PIP2-5, but not as homomers.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10759498, ECO:0000269|PubMed:14671024}; Multi-pass membrane protein {ECO:0000269|PubMed:10759498, ECO:0000269|PubMed:14671024}.
Interaction partners:
- Aquaporin SIP2-1
Sequence:
MEGKEEDVRLGANKFSERQPIGTAAQGAADDKDYKEPPPAPLFEPGELKSWSFYRAGIAEFVATFLFLYITILTVMGVSKSTSKCATVGIQGIAWSFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRALFYIIMQCLGAVCGAGVVKGFQQGLYMGNGGGANVVAPGYTKGDGLGAEIVGTFILVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNRDHAWNDHWIFWVGPFIGAALAAIYHQVIIRAIPFKSRS
Protein: Folylpolyglutamate synthase (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (Tetrahydrofolylpolyglutamate synthase) (M0R401)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}. Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
- Dihydrofolate reductase
- Thymidylate synthase
- Gamma-glutamyl hydrolase
- Methylenetetrahydrofolate dehydrogenase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase
- Nucleotide triphosphate diphosphatase NUDT15
- Monofunctional C1-tetrahydrofolate synthase, mitochondrial
- GTP cyclohydrolase 1
Sequence:
MSWARSHLCSALSLAAVSARGATMEGAAYRWLSAWPAPQEPSMEYQDAVRTLNTLQTNASCLEEVKRQRSDPQAQLEAMEVYLARSGLQVEDLNQLKIIHVTGTKGKGSTCAFTERILRNYGLKTGFFSSPHLVQVRERIRINGKPISPELFTKYFWHLYQQLEEFKDDSHISMPSYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKPGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPPLEALEQVGLPLSLGLEGEHQRHNAALALQLARCWLEQQNYHDIQELKASKPSIRWQLPLAPVFRPTPHMRRGLRDTEWPGRTQVLQRGPVTWYLDGAHTTSSVQACVHWYCQSLERSRRTDGGHEVHILLFNSTGDRDSAALLKLLQPCHFDYAVFCPNVTEISSIGNADQQNFTVTLDQVLLRCLQHQKHWNCLAEKQASSNLWGSCGPESARPGSLLLAPHPPQPTSTSSLVFSCISHALQWISQGRDPIFQPESPPRNLLNHPTANSGASILREAAAIHVLVTGSLHLVGGALRLLDPSMSQ
Protein: P/Homo B domain-containing protein (Q2UUJ5)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- Neutral protease 2 homolog AO090001000135
- Neutral protease 2
- Alkaline protease 1
- Neutral protease 2
- Peptidase S1 domain-containing protein
Sequence:
MRLSESATVAFGLFCAATASAHPRRSYETRDFFALHLDDSTSPDEIAQRLGARHEGQVGELTQHHTFSIPKENGADLDALLEHARIRKRSSRAEGRGMTLDKERDLSGILWSQKLAPKQRLVKRAPPTNVASRGSVKEEDPVAAQAQKRIASSLGITDPIFGGQWHLYNTVQVGHDLNVSDVWLEGITGKGVITAVVDDGLDMYSNDLKPNYFAEGSYDFNDHVPEPRPRLGDDRHGTRCAGEIGAARNDVCGVGVAYDSQVAGIRILSAPIDDADEAAAINYGFQRNDIYSCSWGPPDDGATMEAPGILIKRAMVNGIQNGRGGKGSIFVFAAGNGAGYDDNCNFDGYTNSIYSITVGAIDREGKHPSYSESCSAQLVVAYSSGSSDAIHTTDVGTDKCYSLHGGTSAAGPLAAGTIALALSARPELTWRDAQYLMIETAVPVHEDDGSWQTTKMGKKFSHDWGFGKVDAYSLVQLAKTWELVKPQAWFHSPWLRVKHEIPQGDQGLASSYEITKDMMYQANIEKLEHVTVTMNVNHTRRGDISVELRSPEGIVSHLSTARRSDNAKAGYEDWTFMTVAHWGESGVGKWTVIVKDTNVNDHVGEFIDWRLNLWGLSIDGSSQPLHPMPDEHDDDHSIEDAIVVTTSVDPLPTKTEAPPVPTDPVDRPVNAKPSAQPTTPSEAPAQETSEAPTPTKPSSTESPSTTTSADSFLPSFFPTFGASKRTQAWIYAAISSIIVFCIGLGVYFHVQRRKRLRNDPRDDYDFEMIEDEDETQAMNGRSGRTQRRGGELYNAFAGESDEEPLFSDDEDEPYRDHALSEDRERRGSTSGDHARS
Protein: Lnk-like protein (Q9U8B9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
PHRGEQRLSASSNFDGIEGTENDADVADLTAEMSVFPWFHGTLTRSEAARMVLHSDAAGHGYFLVRQSETRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHLWFPSIQEMLEHFRHNPIPLESGGTSDVTLTEWVHSHSRLNDPTTAANHDSGQLNDLSTNGNGNGNGNGYDNGQGSSTASNAAGGTASGAAGGGHPSPRHCNEVITMNLSVRLKTNEIELPQEPTHVYFPEQVYFHLDPTTLTVHGSPPPAQNFLDQPHLRASNASLQAAAHHQAGSSGNRHPSDGGSNSGGAGGGSGSSGGAECTGRAVDNQYSFT
Protein: Vasorin (Protein slit-like 2) (Q9CZT5)
Organism: Mus musculus (Mouse)
Function: May act as an inhibitor of TGF-beta signaling.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MHSRSCLPPLLLLLLVLLGSGVQGCPSGCQCNQPQTVFCTARQGTTVPRDVPPDTVGLYIFENGITTLDVGCFAGLPGLQLLDLSQNQITSLPGGIFQPLVNLSNLDLTANKLHEISNETFRGLRRLERLYLGKNRIRHIQPGAFDALDRLLELKLPDNELRVLPPLHLPRLLLLDLSHNSIPALEAGILDTANVEALRLAGLGLRQLDEGLFGRLLNLHDLDVSDNQLEHMPSVIQGLRGLTRLRLAGNTRIAQIRPEDLAGLTALQELDVSNLSLQALPSDLSSLFPRLRLLAAARNPFNCLCPLSWFGPWVRENHVVLASPEETRCHFPPKNAGRLLLDLDYADFGCPVTTTTATVPTIRSTIREPTLSTSSQAPTWPSLTEPTTQASTVLSTAPPTMRPAPQPQDCPASICLNGGSCRLGARHHWECLCPEGFIGLYCESPVEQGMKPSSIPDTPRPPPLLPLSIEPVSPTSLRVKLQRYLQGNTVQLRSLRLTYRNLSGPDKRLVTLRLPASLAEYTVTQLRPNATYSICVTPLGAGRTPEGEEACGEANTSQAVRSNHAPVTQAREGNLPLLIAPALAAVLLAVLAAAGAAYCVRRARATSTAQDKGQVGPGTGPLELEGVKAPLEPGSKATEGGGEALSGGPECEVPLMGYPGPSLQGVLPAKHYI
Protein: Voltage-dependent anion channel-forming protein YneE (P76146)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Trans-aconitate 2-methyltransferase
- UPF0162 protein YchA
Sequence:
MIVRPQQHWLRRIFVWHGSVLSKISSRLLLNFLFSIAVIFMLPWYTHLGIKFTLAPFSILGVAIAIFLGFRNNAGYARYVEARKLWGQLMIASRSLLREVKTTLPDSASVREFARLQIAFAHCLRMTLRKQPQAEVLAHYLKTEDLQRVLASNSPANRILLIMGEWLAVQRRNGQLSDILFISLNDRLNDISAVLAGCERIAYTPIPFAYTLILHRTVYLFCIMLPFALVVDLHYMTPFISVLISYTFISLDCLAEELEDPFGTENNDLPLDAICNAIEIDLLQMNDEAEIPAKILPDRHYQLT
Protein: Amino-acid permease BAT1 (Bidirectional amino acid transporter 1) (GABA permease) (AtGABP) (Q9ZU50)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in primary carbon metabolism and plant growth, by mediating the transport of GABA from the cytosol to mitochondria. When expressed in a heterologous system (yeast), imports Arg and Ala across the plasma membrane and exports Lys and Glu, but does not transport proline.
Subcellular location: Mitochondrion membrane {ECO:0000305|PubMed:21501262}; Multi-pass membrane protein {ECO:0000305|PubMed:21501262}.
Interaction partners:
- Glutamate decarboxylase 4
- Glutamate decarboxylase 1
- GABA transporter 1
- Glutamate decarboxylase 2
- Glutamate decarboxylase 5
- Phosphoglycerate mutase-like protein 2
- Proline transporter 2
- Gamma-aminobutyrate transaminase POP2, mitochondrial
- Glutamate decarboxylase 3
- Zinc finger transcription factor YY1
Sequence:
MGLGGDQSFVPVMDSGQVRLKELGYKQELKRDLSVFSNFAISFSIISVLTGITTTYNTGLRFGGTVTLVYGWFLAGSFTMCVGLSMAEICSSYPTSGGLYYWSAMLAGPRWAPLASWMTGWFNIVGQWAVTASVDFSLAQLIQVIVLLSTGGRNGGGYKGSDFVVIGIHGGILFIHALLNSLPISVLSFIGQLAALWNLLGVLVLMILIPLVSTERATTKFVFTNFNTDNGLGITSYAYIFVLGLLMSQYTITGYDASAHMTEETVDADKNGPRGIISAIGISILFGWGYILGISYAVTDIPSLLSETNNSGGYAIAEIFYLAFKNRFGSGTGGIVCLGVVAVAVFFCGMSSVTSNSRMAYAFSRDGAMPMSPLWHKVNSREVPINAVWLSALISFCMALTSLGSIVAFQAMVSIATIGLYIAYAIPIILRVTLARNTFVPGPFSLGKYGMVVGWVAVLWVVTISVLFSLPVAYPITAETLNYTPVAVAGLVAITLSYWLFSARHWFTGPISNILS
Protein: Catalase A (EC 1.11.1.6) (Spore-specific catalase) (P55305)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Subcellular location: Peroxisome matrix {ECO:0000250|UniProtKB:P15202}.
Interaction partners:
- FMN-dependent dehydrogenase family protein
- Kynureninase 1
- Kynureninase 2
- propanoyl-CoA C-acyltransferase
- propanoyl-CoA C-acyltransferase
- Lipid transfer protein, putative
- Catalase-peroxidase
Sequence:
MATSITAGLQKAQQAVQDTATKNKKIVDISHDTVNVHTDQEQRTDFGVAITDPDHWLRVTNETHSGPSLLEDHIARERIHRFDHERIPERVVHARGTGAYGNFTLKESIEDLTYAGVLTDTSRNTPVFVRFSTVQGSRGSADTVRDVRGFAVKFYTDEGNWDIVGNNIPVFFIQDAIKFPDFVHAVKPEPHNEVPQAQTAHNNFWDFVYLHPEATHMFMWAMSDRAIPRSYRMMQGFGVNTFSLVNKEGKRHFVKFHWIPHLGVHSLVWDEALKLAGQDPDFHRKDLMEAIDNKAYPKWDFAIQAIPEEDQDKFEFDIFDATKVWPEEQVPLRVVGELELNRNIDEFFPETEQVAFCTSHIVPGIDFSDDPLLQGRNFSYQDTQISRLGVNWEEIPINRPVCPFLNHNRDGAKRHRITKGTVNYWPNRFEANPPASDKGFKSHPAPITGRKRRDLTPKFKEYHNQAQLFYNSLSEVEKVHVKKAFSFELDHCDDPIVYERLAGQRLAEIDLPLAQAVAEMVGAPIPTKALRDNHGKTSVRLSQFDFTPKAPGIISRRIAIIIGDGYDKIAFNGMKAAILAAQALPFVIGTKRSAIYAQGEDKNSSKGVIPDHMYDGMRSTMFDATFIPGGSHIETLQKNGQIRYWIAETFGHLKALGAMGEAAQLVKEVLGNVMGVQIAGADSAEPVEWYGVVTARGPESAESLSEGFKVLKDAGDFTSKFFYQISQHRNWQRELDGLASTVAF