wanglab/gogpt-training-data huggingface dataset:
Protein: Cell migration inducing hyaluronidase 2 (cDNA FLJ55828, highly similar to Homo sapiens transmembrane protein 2 (TMEM2), mRNA) (B4E1B9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTITRDEYPSNPMVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYLQRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQVVFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLTEKTVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGSTIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQASKAH
Protein: Late embryogenis abundant protein 41 (Protein DROUGHT-INDUCED 21) (AtDI21) (Q39084)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25005920}.
Interaction partners:
- F3E22.8 protein
- AT5g11760/T22P22_150
- Dehydrin Xero 1
- Metallothionein-like protein 3
- Chaperone protein dnaJ 72
- Late embryogenesis abundant domain-containing protein / LEA domain-containing protein
- Heavy metal-associated isoprenylated plant protein 4
- At2g23110
- Late embryogenesis abundant protein 37
Sequence:
MAARSLSGAVKSLCSAASGSLSCSIVLRRSYVATSQNVTAAGLSKGGSTRVMVGKMEQRGLDQEAESAWGPDPVTGYYRPSNRAAEIDPAELRELLLKNKAKSF
Protein: Cornetto (Q967H1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSATLFEMDSQTEEQQQTVCLEEQQLVVGMTSLELSESVVTPGNCDGSDSGLDVASCCHSRITLQRGLSSTSGGYTSSNGLKEIYDSCELKVTTVAQTPSETGSEKTSPPRRTGSVKKKVAMFEPEPTGTPAKDQLRGRVANLKRAESLPRNSAAPGTPGTPSTHRDKARLSTSSFRVPSTTGTPSSSRLARPQKPDTLPNALNRAQSVQRLTQVQRTPSLSRARTPGTPSDDGRWPANRGAARRGMSVTPEVTTNRMRGSPAPGGTLPRRRKQQSVEDLTGGRLSRSNSISRAAIVDARMTSSVMVVPTSRRSLAPAAAKVNSLRRPQPATPRTRIYHETAVQTALTSEDLEQVLGGGLLQTRAVDAVEQRNQSTQAEPDQREFELEQLRHEVRQLSGKLQREREEKLAMQQELHLNTERVMGMLELARVVSASAGTPTSEDSGDGSGHDSLLMLESQIQISGHELFERQQEIGQLRSMCRALQLEMRRSLATQQLLLQEKAAIEQESSELQDFLQHEKAAQCDALRDLEADYQAVKLQLANREEEAKVLRDECRHLVRLNEQRRQENRLLQTKFTALENKSRELIHQQNASVAGASTALSGLHSRLDGLVEQLVYSYSISEQDLEDIRFQAETEHVQNGQRPNGLDLPICPAASGDAIHTLVLASDGSLSPQRNQSFIAAVIGAIRQATTHSGKRLSLRQAGKKNGMGLGSAQAVSAGTQGQEPQGNGDDSDSTEMLDSETEPCLLMMDNVLEDVVHHDSHSHNMVSSCTGMISQIELPTELISQCSHQNNINGGAGGDDSLQQLSQAITNRQQMELHMHKMNGMPMNPRDQCNTEELSCHDSLAELTELPSLMEYSTAQAVVDQVIEVDTLVTKLLKVLRLVQLDNDNCIQQLIVDKNKLQQHKEDMLEKLKDLEDVNLKLQDELMDATQELMIKGSDLSGAKAEMQRHRNEIDVRF
Protein: Mediator of RNA polymerase II transcription subunit 33A (REF4-related 1 protein) (REF4-resembling 1 protein) (Q9LUG9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Involved in the repression of phenylpropanoid biosynthesis. May compete with MED33B for common binding partners or for occupancy in Mediator.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 33B
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 32
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 20a
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 22b
Sequence:
MVVPGRRTVWDCVIELTKMAQENCVDPRLWASQLSSNLKFFAVELPSTELAEVIVSYICWDNNVPIVWKFLERAMALKLVSPLVVLALLADRVVPTRSTQQAAYRIYLELLKRNMFTIKDHISGPHYQKVMISVSNILRLSELFDLDTSKPGVLLVEFVFKMVSQLLDAALSDEGLLELSQDSSSQWLVKSQDMEIDAPERYNEKTGSLEKLQSLNTIMAIELIAEFLRNTVIARLLYLVSSNRASKWHEFVQKVQLLGENSSALKHSKVLNSGDLLQLISNRRFGYSYDSKVTSARKSNAIVDFGSLSSYAGLCHGASLSSLWLPLDLVFEDAMDGYQVNPTSAIEIITGLAKTLKEINGSTWHDTFLGLWIAALRLVQRERDPIEGPIPRLDTRLCMSLCIVPLVVANLIEEGKYESVMEKLRDDLVTSLQVLGDFPGLLAPPKCVVSAANKAATKAILFLSGGNVGKSCFDVINMKDMPVNCSGNMRHLIVEACIARNILDMSAYSWPGYVNGRINQIPQSLPNEVPCWSSFVKGAPLNAAMVNTLVSVPASSLAELEKLFEVAVKGSDDEKISAATVLCGASLTRGWNIQEHTVEYLTRLLSPPVPADYSRAENHLIGYACMLNVVIVGIGSVDSIQIFSLHGMVPQLACSLMPICEEFGSYTPSVSWTLPSGEAISAYSVFSNAFTLLLKLWRFNHPPIEHGVGDVPTVGSQLTPEHLLSVRNSYLVSSEILDRDRNRKRLSEVARAASCQPVFVDSFPKLKVWYRQHQRCIAATLSGLTHGSPVHQTVEALLNMTFGKVRGSQTLNPVNSGTSSSSGAASEDSNIRPEFPAWDILKAVPYVVDAALTACTHGRLSPRQLATGLKDLADFLPASLATIVSYFSAEVSRGVWKPVFMNGVDWPSPATNLSTVEEYITKILATTGVDIPSLAPGGSSPATLPLPLAAFVSLTITYKIDKASERFLNLAGPALECLAAGCPWPCMPIVASLWTQKAKRWFDFLVFSASRTVFLHNQDAVIQLLRNCFSATLGLNAAPMSNDGGVGALLGHGFGSHFYGGISPVAPGILYLRMYRALRDTVSVSEEILSLLIHSVEDIAQNRLSKEKLEKLKTVKNGSRYGQSSLATAMTQVKLAASLSASLVWLTGGLGVVHVLIKETIPSWFLSTDKSDREQGPSDLVAELRGHALAYFVVLCGALTWGVDSRSSASKRRRQAILGSHLEFIASALDGKISVGCETATWRTYISGLVSLMVSCLPLWVTEIDTEVLKSLSNGLRKWGKDELAIVLLSLGGLKTMDYAADFIIHLRS
Protein: ABC transporter I family member 17 (ABC transporter ABCI.17) (AtABCI17) (MRP-related protein 1) (Non-intrinsic ABC protein 3) (Q9C9W0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein ALUMINUM SENSITIVE 3
- Protein ABCI7, chloroplastic
- ABC transporter I family member 6, chloroplastic
- Protein transport protein Sec61 subunit beta
- Preprotein translocase Sec, Sec61-beta subunit protein
- Protein TRIGALACTOSYLDIACYLGLYCEROL 1, chloroplastic
- ABC transporter I family member 20
- Iron-sulfur cluster assembly SufBD family protein ABCI8, chloroplastic
- Cytochrome C assembly protein
- ABC transporter-like protein
Sequence:
MPSLWSNESDGSLREHLVDVVVSGSEPKIRVHDLTRVADDGSRILKGVTIDIPKGMIVGVIGPSGSGKSTFLRSLNRLWEPPESTVFLDGEDITNVDVIALRRRVGMLFQLPVLFQGTVADNVRYGPNLRGEKLSDEEVYKLLSLADLDASFAKKTGAELSVGQAQRVALARTLANEPEVLLLDEPTSALDPISTENIEDVIVKLKKQRGITTVIVSHSIKQIQKVADIVCLVVDGEIVEVLKPSELSHATHPMAQRFLQLSS
Protein: Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (Q9CPR4)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}.
Interaction partners:
- Large ribosomal subunit protein eL21
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein eS25
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS15
Sequence:
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE
Protein: Condensin-2 complex subunit (Q8MSN8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR036508}.
Interaction partners:
Sequence:
MRQTFPMHVYTDSPQMIAYGRRGAMQTGEHISDWFIQLIDKYPDIVNRILHFYIECVVSNPIKAWKSNDEKVAIGYAAKYDRVLFTKCNKSCADYVLEAVKADDAVGIQIRALDLIEKILLQESEVEWSIFRHEVSDVPREVPLLREVLRCLNDRTLTVRRKACQVLILALRQGSPMTKKILQESIRFVQFDDTDVEALAEPSAQQNELRFEKPGIVQYAFSFQGHEQLETEVKNLPQTVYQRFLAADNGLARSAGIALLERLVLVNPLIIYNTNFVKETSLLAVDRLSSVRKSALETIETLLEAYSNCFALICVYCRIWACLMSDEDVALQKLAISSFDRMVLKNIQPLEYSNEAKHFMPWRIISTLLMTQPRAYLQERFAVLLERETIVTPRLVNVIISHLSTSMATDAWGLLLFLSSRITNNMDALIGIFNGLSSYNMKSNQFLALQLITGCLRNFSKPALNQLFQKLLNALRTGSIWLGIISSAVNLLNQIHHLSTSQSPTIASEMPYWQLSLLEDLVEGILSSAQNFQEEYARLQCLLGAYTELIVMVPQDVDNRIVSIVFKYLQECTKLCESEFDSDNERMTNWMIVIAGRLSLRDNHLANSASKLYITILTKNDRPQIINTTLIALNDLGKKHPSILESNFQAILSKLQSKFAMTRVRTFRCVKDVILSGNIKLKGPILISMLAALVDESAEVAREADAFFTRYKKLYNKMLFDHCLKECPFDLNDQAILRGVRTNGNYKSPLKGSQMAKKRRLLYNHIMSSMDENVLLLYFGQLKLLAEKTRDQAFINNPDALIVVQDMLFIMRRICYCTKGMGKEKNSRGEGDNIDEGEDASSEPATPPTRPEAGEATSRGRGRKADMSEEPLKQLERCLRFVEETHRNIVSVMSPELSQNFESFCRAMAMRFPNYIEFAQPAQFWRQFRSSAKAPRASRSKRRRMEEGEVESHEEHESESDSDSELPLDRHKTTPTASRLSQRKTSCDMLVTELIFQPPDW
Protein: Syntaxin-2 (Epimorphin) (P32856)
Organism: Homo sapiens (Human)
Function: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Subcellular location: Membrane; Single-pass type IV membrane protein.
Interaction partners:
- Vesicle-associated membrane protein 2
- Synaptosomal-associated protein 23
- Vesicle-associated membrane protein 3
- Syntaxin-binding protein 1
- Vesicle-associated membrane protein 8
- Vesicle-associated membrane protein 1
- Vesicle-associated membrane protein 4
- Alpha-2,8-sialyltransferase 8B
- Alpha-soluble NSF attachment protein
- Synaptosomal-associated protein 25
Sequence:
MRDRLPDLTACRKNDDGDTVVVVEKDHFMDDFFHQVEEIRNSIDKITQYVEEVKKNHSIILSAPNPEGKIKEELEDLNKEIKKTANKIRAKLKAIEQSFDQDESGNRTSVDLRIRRTQHSVLSRKFVEAMAEYNEAQTLFRERSKGRIQRQLEITGRTTTDDELEEMLESGKPSIFTSDIISDSQITRQALNEIESRHKDIMKLETSIRELHEMFMDMAMFVETQGEMINNIERNVMNATDYVEHAKEETKKAIKYQSKARRKKWIIIAVSVVLVAIIALIIGLSVGK
Protein: Protein AUXIN RESPONSE 4 (Q9FZ33)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the auxin influx facilitator AUX1 polar trafficking and its asymmetric localization within the plasma membrane. Not involved in the PIN proteins localization.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16690816}; Single-pass membrane protein {ECO:0000269|PubMed:16690816}.
Interaction partners:
- Auxin transporter protein 1
- NEDD8-activating enzyme E1 regulatory subunit AXR1
- F-box protein At1g55000
- Auxin efflux carrier component 2
- Protein AUXIN SIGNALING F-BOX 3
Sequence:
MAIITEEEEDPKTLNPPKNKPKDSDFTKSESTMKNPKPQSQNPFPFWFYFTVVVSLATIIFISLSLFSSQNDPRSWFLSLPPALRQHYSNGRTIKVQVNSNESPIEVFVAESGSIHTETVVIVHGLGLSSFAFKEMIQSLGSKGIHSVAIDLPGNGFSDKSMVVIGGDREIGFVARVKEVYGLIQEKGVFWAFDQMIETGDLPYEEIIKLQNSKRRSFKAIELGSEETARVLGQVIDTLGLAPVHLVLHDSALGLASNWVSENWQSVRSVTLIDSSISPALPLWVLNVPGIREILLAFSFGFEKLVSFRCSKEMTLSDIDAHRILLKGRNGREAVVASLNKLNHSFDIAQWGNSDGINGIPMQVIWSSEASKEWSDEGQRVAKALPKAKFVTHSGSRWPQESKSGELADYISEFVSLLPKSIRRVAEEPIPEEVQKVLEEAKAGDDHDHHHGHGHAHAGYSDAYGLGEEWTTT
Protein: Free methionine-R-sulfoxide reductase (fRMsr) (EC 1.8.4.14) (P76270)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Specific for free L-methionine-(R)-S-oxide.
Interaction partners:
- Peptide methionine sulfoxide reductase MsrA
- RNA chaperone ProQ
- Homocysteine S-methyltransferase
- Aromatic-amino-acid aminotransferase
- S-adenosylmethionine synthase
- Methionine synthase
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Peptide methionine sulfoxide reductase MsrB
- Biotin sulfoxide reductase
- Protein-methionine-sulfoxide reductase catalytic subunit MsrP
Sequence:
MNKTEFYADLNRDFNALMAGETSFLATLANTSALLYERLTDINWAGFYLLEDDTLVLGPFQGKIACVRIPVGRGVCGTAVARNQVQRIEDVHVFDGHIACDAASNSEIVLPLVVKNQIIGVLDIDSTVFGRFTDEDEQGLRQLVAQLEKVLATTDYKKFFASVAG
Protein: UDP-arabinopyranose mutase 2 (EC 5.4.99.30) (Reversibly glycosylated polypeptide 2) (AtRGP2) (UDP-L-arabinose mutase 2) (Q9LFW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: UDP-L-arabinose mutase involved in the biosynthesis of cell wall non-cellulosic polysaccharides. Catalyzes the interconvertion of UDP-L-arabinopyranose (UDP-Arap) and UDP-L-arabinofuranose (UDP-Araf) in vitro. Preferentially catalyzes the formation of UDP-Arap from UDP-Araf. At thermodynamic equilibrium in vitro the ratio of the pyranose form over the furanose form is 95:5. Is not active on other UDP-sugars (UDP-Gal, UDP-Xyl, UDP-Glc, GDP-Man and GDP-Fuc). Functions redundantly with RGP2 and is essential for proper cell walls and pollen development. Probably involved in the formation of the pectocellulosic cell wall layer intine. Is probably active as heteromer in vivo.
Subcellular location: Cytoplasm, cytosol. Golgi apparatus. Note=Soluble and membrane-associated. {ECO:0000269|PubMed:17071651, ECO:0000269|PubMed:21478444}.
Interaction partners:
- UDP-sugar pyrophosphorylase
- UDP-arabinopyranose mutase 1
- UDP-arabinose 4-epimerase 1
- Actin-related protein 4
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 3
- Small ribosomal subunit protein RACK1z
- Probable arabinosyltransferase ARAD1
- Ankyrin repeat-containing protein At5g02620
- F-actin-capping protein subunit beta
Sequence:
MVEPANTVGLPVNPTPLLKDELDIVIPTIRNLDFLEMWRPFLQPYHLIIVQDGDPSKKIHVPEGYDYELYNRNDINRILGPKASCISFKDSACRCFGYMVSKKKYIFTIDDDCFVAKDPSGKAVNALEQHIKNLLCPSSPFFFNTLYDPYREGADFVRGYPFSLREGVSTAVSHGLWLNIPDYDAPTQLVKPKERNTRYVDAVMTIPKGTLFPMCGMNLAFDRDLIGPAMYFGLMGDGQPIGRYDDMWAGWCIKVICDHLSLGVKTGLPYIYHSKASNPFVNLKKEYKGIFWQEEIIPFFQNAKLSKEAVTVQQCYIELSKMVKEKLSSLDPYFDKLADAMVTWIEAWDELNPPAASGKA
Protein: Actin-like protein ARP8 (Q12386)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Exhibits low basal ATPase activity, and unable to polymerize. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
Subcellular location: Nucleus. Cytoplasm, cytoskeleton.
Interaction partners:
- Actin
- Actin-related protein 4
- Ino eighty subunit 4
- Chromatin-remodeling ATPase INO80
- Actin-related protein 5
- Chromatin-remodeling complex subunit IES6
- RuvB-like protein 2
- Ino eighty subunit 3
- Non-histone protein 10
- RuvB-like protein 1
Sequence:
MSQEEAESSIIYEEPIDIPLEDDDDEDELEEENSVPLSSQADQENAENESDDSVDNVVGSETPRSVTGLSVDPRDVADEEDEDEEGEDEDEDEDDNDVDNEDENDNDNANENENELGSSRDKRAPPAVQTSKRYKKYPKLDPAKAPPGKKVPLHLLEKRRLGRIKAAEEFAKTLKKIGIEKVETTTLPATGLFQPLMLINQKNYSSDYLKKDDQIFALRDRKFLRNNNTSQISSTNTPDVIDLKSLPHSEASAAPLNDEIDLNDPTATIVIHPGSNSIKIGFPKDDHPVVVPNCVAVPKKWLDLENSEHVENVCLQREQSEEFNNIKSEMEKNFRERMRYYKRKVPGNAHEQVVSFNENSKPEIISEKNDPSPIEWIFDDSKLYYGSDALRCVDEKFVIRKPFRGGSFNVKSPYYKSLAELISDVTKLLEHALNSETLNVKPTKFNQYKVVLVIPDIFKKSHVETFIRVLLTELQFQAVAIIQESLATCYGAGISTSTCVVNIGAAETRIACVDEGTVLEHSAITLDYGGDDITRLFALFLLQSDFPLQDWKIDSKHGWLLAERLKKNFTTFQDADVAVQLYNFMNRSPNQPTEKYEFKLFDEVMLAPLALFFPQIFKLIRTSSHKNSSLEFQLPESRDLFTNELNDWNSLSQFESKEGNLYCDLNDDLKILNRILDAHNIIDQLQDKPENYGNTLKENFAPLEKAIVQSIANASITADVTRMNSFYSNILIVGGSSKIPALDFILTDRINIWRPSLLSSASFPQFYKKLTKEIKDLEGHYVNAPDKTEDENKQILQAQIKEKIVEELEEQHQNIEHQNGNEHIFPVSIIPPPRDMNPALIIWKGASVLAQIKLVEELFITNSDWDVHGSRILQYKCIFTY
Protein: Tubulin alpha chain (Q6NWK7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Tubulin beta chain
- Tight junction protein 1a
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSIEGEGEEEGEEY
Protein: Thymidine kinase 2 (A0A8I5ZTL4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLLRSLRSWAARSLRSMGPGSSGSPGSLDSGAGPLWAPRRACPPDKDREKDKEKKAVVCIEGNIASGKTTCLEFFSNTTDVEVLMEPVLKWRNVHGHNPLSLMYHNASRWGLTLQTYVQLTMLDQHTRPQWEDARG
Protein: ADP-ribosylation factor 1 (PfARF1) (EC 3.6.5.2) (Q7KQL3)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). Regulates the transport of N-acylated AK2 to the parasitophorous vacuole membrane. May be involved in the activation of lipid kinase PIP5K.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:33604307}; Lipid-anchor {ECO:0000250|UniProtKB:P84077}; Cytoplasmic side {ECO:0000305}. Note=In the GDP-bound form, associates transiently with the membranes via its myristoylated N-terminus where guanine nucleotide-exchange factor (GEF)-mediated nucleotide exchange occurs (By similarity). Following nucleotide exchange, the GTP-bound form undergoes a conformational change, leading to the exposure of a myristoylated N-terminal amphipathic helix that provides stable membrane anchorage (By similarity). {ECO:0000250|UniProtKB:P84080}.
Interaction partners:
- Gametocyte-specific protein
- Kinesin-like protein
- Coatomer subunit gamma
- Protein transport protein SEC7, putative
- ADP-ribosylation factor GTPase-activating protein
- Glycylpeptide N-tetradecanoyltransferase
- AP complex subunit beta
- AP complex subunit beta
- AP-1 complex subunit gamma, putative
- AP-4 complex subunit epsilon, putative
Sequence:
MGLYVSRLFNRLFQKKDVRILMVGLDAAGKTTILYKVKLGEVVTTIPTIGFNVETVEFRNISFTVWDVGGQDKIRPLWRHYYSNTDGLIFVVDSNDRERIDDAREELHRMINEEELKDAIILVFANKQDLPNAMSAAEVTEKLHLNTIRERNWFIQSTCATRGDGLYEGFDWLTTHLNNAK
Protein: Fibroblast growth factor 7 (FGF-7) (Heparin-binding growth factor 7) (HBGF-7) (Keratinocyte growth factor) (P21781)
Organism: Homo sapiens (Human)
Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
Subcellular location: Secreted.
Interaction partners:
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 4
- Pro-epidermal growth factor
- Fibroblast growth factor-binding protein 1
- Klotho
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Fibroblast growth factor receptor 3
- Decorin
- Vascular endothelial growth factor receptor 2
Sequence:
MHKWILTWILPTLLYRSCFHIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT
Protein: EP300-interacting inhibitor of differentiation 2 (EID-2) (CREBBP/EP300 inhibitor 2) (EID-1-like inhibitor of differentiation 2) (Q8N6I1)
Organism: Homo sapiens (Human)
Function: Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:14585496}.
Interaction partners:
- EP300-interacting inhibitor of differentiation 3
- Structural maintenance of chromosomes protein 5
Sequence:
MSKLPADSSVPQTGAANGDRDVPQAEVGRGRREPAPAQPEEAGEGAMAAARGGPVPAAREGRMAAARAAPAAAARGAPVAAAALARAAAAGRESPAAAAAREARMAEVARLLGEPVDEEGPEGRPRSRHGNGGLAALPYLRLRHPLSVLGINYQQFLRHYLENYPIAPGRIQELEERRRRFVEACRAREAAFDAEYQRNPHRVDLDILTFTIALTASEVINPLIEELGCDKFINRE
Protein: Small ribosomal subunit protein uS10 (40S ribosomal protein S20) (P55828)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein uS11A
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein eL8
- Small ribosomal subunit protein eS10B
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein eL19
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL43
Sequence:
MAAAPKDIEKPHVGDSASVHRIRITLTSRNVRSLENVCRDLINGAKNQNLRVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRIIDLHSPSEIVKKITSINIEPGVEVEVTIAN
Protein: Uncharacterized ABC transporter ATP-binding protein C16H5.08c (O42943)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit gar1
- Putative ribosomal RNA-processing protein 12
- Uncharacterized protein C1105.01
- Translation initiation factor rli1
- rRNA 2'-O-methyltransferase fibrillarin
- mRNA export factor elf1
- Eukaryotic translation initiation factor 5B
- Eukaryotic translation initiation factor 6
- Elongation factor 3
- DNA-directed RNA polymerase I subunit rpa1
Sequence:
MSSKSASKLKREAKKAERLAAKGESVKPSKKNGTKNGKDKEVDGVTKDLSELSTSDPIFERSASGVLTSQPMSRDIKIDSYTLSFHGRLLIENATIELNHGQRYGLLGDNGSGKSTFLESVAARDVEYPEHIDSYLLNAEAEPSDVNAVDYIIQSAKDKVQKLEAEIEELSTADDVDDVLLESKYEELDDMDPSTFEAKAAMILHGLGFTQEMMAKPTKDMSGGWRMRVALSRALFIKPSLLLLDEPTNHLDLEAVVWLENYLAKYDKILVVTSHSQDFLNNVCTNIIDLTSKKQLVYYGGNFDIYMRTKEENETNQMKAYLKQQEEIAHIKKFIASAGTYANLVRQAKSKQKIIDKMEAAGLVEKPEPPRQFSFEFDEVRKLPPPIIAFNDVAFSYDGNLDHALYRDLSFGIDMDSRVAIVGKNGTGKSTLLNLITGLLIPIEGNVSRYSGLKMAKYSQHSADQLPYDKSPLEYIMDTYKPKFPERELQQWRSVLGKFGLSGLHQTSEIRTLSDGLKSRVVFAALALEQPHILLLDEPTNHLDITSIDALAKAINVWTGGVVLVSHDFRLIGQVSKELWEVKDKKVVKLDCSIEEYKKSMAKEVQSRDTTAKVKHLI
Protein: E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) (P16581)
Organism: Homo sapiens (Human)
Function: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12649084, ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein.
Interaction partners:
- P-selectin glycoprotein ligand 1
- Golgi apparatus protein 1
- CD44 antigen
- Integrin beta-2
- L-selectin
- Leukosialin
- Cadherin-5
- Alpha-
- Vascular cell adhesion protein 1
- Platelet endothelial cell adhesion molecule
Sequence:
MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL