wanglab/gogpt-training-data huggingface dataset:
Protein: Eukaryotic translation initiation factor 3 subunit C-like protein (B5ME19)
Organism: Homo sapiens (Human)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q99613}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 5
Sequence:
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAAEKKREDKAKKKHDRKSKRLDEEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQIAAENNLGEGVIVKIKFNIIASLYDYNPNLATYMKPEMWGKCLDCINELMDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY
Protein: ARS-binding protein 2 (Q9USY4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds, preferentially, to the Maundrell ARS consensus sequence within ARS3002.
Subcellular location: Nucleus {ECO:0000269|PubMed:9488484}.
Interaction partners:
- Putative ATP-dependent RNA helicase ste13
- mRNA-decapping enzyme subunit 1
- mRNA decapping complex subunit 2
- Uncharacterized protein C2A9.02
- Chromodomain helicase hrp3
- Chromodomain helicase hrp1
Sequence:
MNFYSLLPSRHDVSADNITEKFCQFCLCCNPWYAGADTRQLANAFNMIPKSEGQKFEIWVLFLLVRQYHQKIINSWSKLVGFLGVERKDEQSTQKIQQYVVRLKRWMSQTHVDAFFDYLLNKPNPYYLEIPETQPQVRCNVNVTDDLVIKSLRAGLMSHPDVNSSSISTMRTSTSPSNWIHSASASLDDNTHNLGSFVTNPHADSQECPTPQSLLMRASHHMSERGSQQAHQTTPQNHSLPHPPNMFEPPDEDHQLPSAANNSHNHDHAFQTAEAVGVADSIDPDWHQWPDDLRDVSSPKESDGLNDSWSRQTNQVETENVENEAGVPRKRGRPPGARNKIKRLRSEPSVSLTLSISWYERFEKLMHAQNTMLRSAFSHVARLPMETVSQLLSHYTETISQYLPPSETSPIPKTPNFKFISSTLLALVSSHSEILEASTDRLIWTVHQGPLTATICHAFNLEKAPSMHSLAEAQMIPDVPISHSNSMEPLDTVSSLKLEIAKLNAALKEKNLELENLKRKIMNAVFD
Protein: BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) (Q8IXM2)
Organism: Homo sapiens (Human)
Function: Component of chromatin complexes such as the MLL1/MLL and NURF complexes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Nucleosome-remodeling factor subunit BPTF
- HMG domain-containing protein 4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1
- Histone-binding protein RBBP4
- Protein dpy-30 homolog
- WD repeat-containing protein 5
- Bromodomain adjacent to zinc finger domain protein 1A
- Retinoblastoma-binding protein 5
- Histone acetyltransferase KAT8
Sequence:
MTSASTKVGEIFSAAGAAFTKLGELTMQLHPVADSSPAGAKWTETEIEMLRAAVKRFGDDLNHISCVIKERTVAQIKATVKRKVYEDSGIPLPAESPKKGPKKVASGVLSPPPAAPPPSSSSVPEAGGPPIKKQKADVTLSALNDSDANSDVVDIEGLGETPPAKKLNFDQA
Protein: Myelin-associated glycoprotein (1B236) (Brain neuron cytoplasmic protein 3) (Sialic acid-binding Ig-like lectin 4a) (Siglec-4a) (P07722)
Organism: Rattus norvegicus (Rat)
Function: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth. Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16998591, ECO:0000269|PubMed:19367338, ECO:0000269|PubMed:8995428, ECO:0000269|PubMed:9298990}; Single-pass type I membrane protein {ECO:0000269|PubMed:16998591, ECO:0000269|PubMed:19367338, ECO:0000269|PubMed:9298990}. Membrane raft {ECO:0000269|PubMed:16998591}.
Interaction partners:
- Reticulon-4 receptor
- Reticulon-4
- Oligodendrocyte-myelin glycoprotein
- Myelin basic protein
- Leucine rich repeat and Ig domain containing 1
- Myelin-oligodendrocyte glycoprotein
- Reticulon-4 receptor-like 2
- Tumor necrosis factor receptor superfamily member 16
- Myelin proteolipid protein
- 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Sequence:
MIFLTTLPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIINTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAESLYLDLEEVTPAEDGIYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTLRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPHVLYSPEFRISGAPDKYESEKRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
Protein: Agamous-like MADS-box protein AGL62 (Q9FKK2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor. Required for suppression of cellularization and promotion of nuclear proliferation during early endosperm development. The FERTILIZATION-INDEPENDENT SEED (FIS) polycomb complex is required for suppression of ALG62 expression at the end of the syncytial phase of endosperm development.
Subcellular location: Nucleus.
Interaction partners:
- MADS-box transcription factor PHERES 1
- Agamous-like MADS-box protein AGL90
- Agamous-like MADS-box protein AGL36
- MADS-box transcription factor PHERES 2
- Agamous-like MADS-box protein AGL63
- AGAMOUS-like-34
- Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2
- Probable WRKY transcription factor 10
- Receptor-like protein kinase HAIKU2
- Histone-lysine N-methyltransferase MEDEA
Sequence:
MVKKSKGRQKIEMVKMKNESNLQVTFSKRRSGLFKKASELCTLCGAEVAIVVFSPGRKVFSFGHPNVDSVIDRFINNNPLPPHQHNNMQLRETRRNSIVQDLNNHLTQVLSQLETEKKKYDELKKIREKTKALGNWWEDPVEELALSQLEGFKGNLENLKKVVTVEASRFFQANVPNFYVGSSSNNAAFGIDDGSHINPDMDLFSQRRMMDINAFNYNQNQIHPNHALPPFGNNAYGINEGFVPEYNVNFRPEYNPNQNQIQNQNQVQIQIQNQSFKRENISEYEHHHGYPPQSRSDYY
Protein: SUMO-conjugating enzyme UBC9 (EC 6.3.2.19) (Q8I301)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Small ubiquitin-related modifier
- Ran-specific GTPase-activating protein 1, putative
- SUMO-activating enzyme subunit
- MATH and LRR domain-containing protein PFE0570w
- Proliferating cell nuclear antigen 1
- E3 SUMO-protein ligase NSE2, putative
- Aspartyl protease
- SUMO-activating enzyme subunit 1
- Uncharacterized protein
- E3 SUMO-protein ligase PIAS, putative
Sequence:
MSIAKKRLAQERAEWRKDHPAGFSAKYSPMSDGKGLDIMKWICKIPGKKGGLWEGGEYPLTMEFTEDYPSKPPKCKFTTVLFHPNIYPSGTVCLSILNEDEDWKPSITIKQILLGIQDLLDNPNPNSPAQAEPFLLYQQDRDSYEKKVKKQAIEFRPKD
Protein: DH domain-containing protein (Q54P24)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- SH3 domain-containing protein
Sequence:
MPIQFDAGLEQQVNQFLGDVDDFLTVKTGTTVDKLKSLLNCEEKSISYNAIAFLAFANQAAVNKDASREAGLIKLFLEFCHPSKIITVLPMVKHASMGLMFLANHSDENKKEIGDLKGIDTIFELLRDLLVMIKSPPEDVKKEDIVSSISQSLNLVIFLASLQSNREVMGTVQNFLVLNSLLAYENPQSLDLQLQIQEKALSATNNICMHKENKENCRVAGCIENVLKLLKSTKPSIQDSSLRMLYNMTITDANREAIRRCKGLETLASMLSGQAEALTLLSLKALSNMAVDRQTIEYAVANQESVLQPIYGVFPSSYGQGCSDALLDQVLTVIQNLVSEENLIDTVAKSGIIAKLVGATKGMPLTNTTHQSILVKASCIISALITIEEVQQAAVEQGVITLLVEMIQLPSAEVRREAARALANATPYYDDVRAEIGAQGGVKLCVDLLLQADKELVKQAARALVNLARNTHNEEKLYESKGLEHSIRLINSPEKDLKMLGTKLLVNLSLNEQARIAFCQKGGLSIVVQLLTSSDPELQLQGTKIATNLAISGRNRKVMNEQAPDLIPALKALVNSSVSDIKLQSEVSLNNLAFPYEASYEGLDQMEDAMPIFMQSSQYERDDDDEDDEDEAEKDERRRQEEEELRLAAEKEVEERKRIMQEEVKRIEERRKAEHEKRLQEEQELRQKKEEAEKLRLAQEAMEKLRLEQEAAAAAEAEKIRLAEEQRIIKEKEVAEQERIKQLTEQQKQKEEEEAKIALEKAKKEEAERLEKAEALRLQKEQEERIRKEKEIEAERLRVQEEERLAKERQAEEDRMRAVEEEKLKLMEAEIKQREEDIRRQKIEEEERRKREEQEKKLKDQQDKASQESARLAQEAARAQKRTHIVQEIMQVEVNYVKNLTLMVRKFLHPLAQLSTSKRPLLTPDRITQIFSTIENIQNHNSIFSDGLTSRIKRWLADNKKDHLIIGDIFQKIGGFMQDYSKYINNYNQSIKTYNETKKTNLPFAQFIKKVESDPELNDRELENLLITPVQQLPRYIMLIQDLIRNTHDDHPDYKPLTEALDKIKHITTIINEKKRDAEDAFAMLQIHQQVHGKVPNNFVTPHRKFIREGAVHFGSSSGSFKDKDPIVFLFNDMVMMTIKHPNKPNEYKYRYSCQFSTTTTIEELPSVNNGFIIKSNQWWSFSCSTPQEKTSWMETIQKSLTNLPKESKVLTSKK
Protein: Dentin matrix acidic phosphoprotein 1 (DMP-1) (Dentin matrix protein 1) (AG1) (O55188)
Organism: Mus musculus (Mouse)
Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity). {ECO:0000250}.
Interaction partners:
- Matrix metalloproteinase-9
- Matrix extracellular phosphoglycoprotein
- Integrin-binding sialoprotein
- Integrin alpha-V
- Integrin beta-3
- Phosphate-regulating neutral endopeptidase PHEX
- Dentin sialophosphoprotein
- Fibroblast growth factor 23
- Osteopontin
- Stromelysin-1
Sequence:
MKTVILLVFLWGLSCALPVARYHNTESESSEERTGDLAGSPPPPTNSESSEESQASPEGQANSDHTDSSESGEELGYDRGQYRPAGGLSKSTGTGADKEDDEDDSGDDTFGDEDNDLGPEEGQWGGPSKLDSDEDSTDTTQSSEDSTSQENSAQDTPSDSKDHDSEDEADSRPEAGDSTQDSESEEQRVGGGSEGESSHGDGSEFDDEGMQSDDPESTRSDRGHARMSSAGIRSEESKGDHEPTSTQDSDDSQSVEFSSRKSFRRSHVSEEDYRGELTDSNSRETQSDSTEDTASKEESRSESQEDTAESQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVTSESRGDNPDNTSQAGDQEDSESSEEDSLNTFSSSESQSTEEQADSESNESLSLSEESQESAQDGDSSSQEGLQSQSASTESRSQESQSEQDSRSEEDSDSQDSSRSKEESNSTGSASSSEEDIRPKNMEADSRKLIVDAYHNKPIGDQDDNDCQDGY
Protein: VPS10 domain-containing receptor SorCS3 (Q8VI51)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- PRKCA-binding protein
Sequence:
MEAAGTERPAGWPGAPLARTGLLLLSTWVLAGAEITWGATGGPGRLVSPASRPPVLPPLLPRAAENRWPEELASARRAAAPRRRSRLEPLSQASRGEIRTEAAGMSPEGARWVPGIPSPSQAGSARRTRRAQPPSPLERGDSWATALADGAKGSRPHTKGSREEVRATRTGGASTEELRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSVDYGATYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSVLISSDEGATYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVSGLDKEADLVHMEVRTADGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTIGGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKDTAPGLVVATGNIGSELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTLLPLFVDGALVEAGVETHIMTVFGHFSLRSEWQLVKVDYKSIFSRRCTKEDFETWHLLNQGEPCVMGERKIFKKRKPGAQCALGREYSGSVVSEPCVCADWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLRDKYSAKTQLCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGVAVSYANFSPIEDGIRHVYKSAGIFQVTAYAENNLGSDTAFLFLHVVCPVEHVHLRVPFVAIRNKDVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTNTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRQDIGNVIKRALIKVTSVPEDQILVAVFPGLPTSAELFILPPKNLTERRKGHEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGSIATIASSESTKEIPNCTSV
Protein: Glyceraldehyde-3-phosphate dehydrogenase GAPB, chloroplastic (EC 1.2.1.13) (NADP-dependent glyceraldehydephosphate dehydrogenase B) (P25857)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the photosynthetic reductive pentose phosphate pathway (Calvin-Benson cycle). Catalyzes the reduction of 1,3-diphosphoglycerate by NADPH (By similarity).
Subcellular location: Plastid, chloroplast membrane {ECO:0000250|UniProtKB:P25856}; Peripheral membrane protein {ECO:0000250|UniProtKB:P25856}. Plastid, chloroplast stroma {ECO:0000250|UniProtKB:P25856}.
Interaction partners:
- Triosephosphate isomerase, chloroplastic
- Phosphoglycerate kinase 1, chloroplastic
- Triosephosphate isomerase, cytosolic
- Fructose-bisphosphate aldolase 2, chloroplastic
- Phosphoglycerate kinase 3, cytosolic
- Transketolase-1, chloroplastic
- Sedoheptulose-1,7-bisphosphatase, chloroplastic
- Phosphoglycerate kinase 2, chloroplastic
- Glyceraldehyde-3-phosphate dehydrogenase GAPA2, chloroplastic
- Transketolase-2, chloroplastic
Sequence:
MATHAALAVSRIPVTQRLQSKSAIHSFPAQCSSKRLEVAEFSGLRMSSIGGEASFFDAVAAQIIPKAVTTSTPVRGETVAKLKVAINGFGRIGRNFLRCWHGRKDSPLEVVVLNDSGGVKNASHLLKYDSMLGTFKAEVKIVDNETISVDGKLIKVVSNRDPLKLPWAELGIDIVIEGTGVFVDGPGAGKHIQAGASKVIITAPAKGADIPTYVMGVNEQDYGHDVANIISNASCTTNCLAPFAKVLDEEFGIVKGTMTTTHSYTGDQRLLDASHRDLRRARAAALNIVPTSTGAAKAVSLVLPQLKGKLNGIALRVPTPNVSVVDLVINVEKKGLTAEDVNEAFRKAANGPMKGILDVCDAPLVSVDFRCSDVSTTIDSSLTMVMGDDMVKVVAWYDNEWGYSQRVVDLAHLVASKWPGAEAVGSGDPLEDFCKTNPADEECKVYD
Protein: Protein ECT2 (Q22590)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDVSMLQSPQKRIKTIQKLAVSKKDVHDFKDIFEMLEEQKEKRNINIIQYDSLDDLSGDWSEYTFFCGNFDSDLFRTLTKHQETQALFIIGASVLKNKLLKNEDLMTLRAARPLYCELMKDVTMKLAAEVPNKRELVDLVHYMGGSVRKDTVSRTNVFIAAKVEAKVQSISLVGVPTMRADWVTECWKHRDDSYFDVMEPCFVDKHRLGVFEGLSLFFHGFKQTEIDDMLRSLENTGGKLAPSPTLATHVVYNPDNDEVETLAVSSNQVHVTKEWFWVSLHRGCCAIEDNFALPTGKLHRKPLESSSVSSPIGKSLRSQNSRSLSSMRDCSVEGPTSLNMTPDYIYSNDDVENSCKSPRQPSKRLRVCMEMVETEKNYLSLLKLVVKFKEALECEISHNEFMSRSDVAMMFGKLDPILELHERIFARLTVMSNEANTLLTVVNGKKNDDKNLDFAQVWIDAKEEMKKAYPQYINSYDTIKRLFDKQDRENSKFHTFCKAKESNPEFHRLKLTDLMVKPVQRLPSVILLLKEMAKKSDSKLKNNAEEAAKAIDEVLKTANKTREKNDNFISHLSKFTDIENVPPILVAANRMFIRELVVSPIASTSPGLQQFAKMKLFLFHDVLIITKIRSEKNTMQRLARHASFASLHSRQRRPYRYIDQIQLNTMRSAFRIRAPDEIAKCLELQQQNGSTKPNVFVWCLIHRDEQGGDIDTVFESNDDEEVRDFLDDIHVKILSDCGRFFYSSDPSDMNEINDAMVSDMTTRYFRNLCGAKPQYGHGSQMNITEWSHNESFMPPPQSQSRMRRAFSNAQLTLATTLGFGRNQSRNNLGQINENTTFLQSPRVSCDPAALANMTSVGGLPGCQSESESTPKRGIRSRLTSTTFLGGRHNILGRNTSMRRQATGFAHSEKELPRSKTSSYRVTDI
Protein: Uncharacterized protein Rv1265 (P9WM49)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- HTH-type transcriptional regulator Cmr
Sequence:
MVLARPDAVFAPARNRCHVSLPVNAMSLKMKVCNHVIMRHHHMHGRRYGRPGGWQQAQQPDASGAAEWFAGRLPEDWFDGDPTVIVDREEITVIGKLPGLESPEEESAARASGRVSRFRDETRPERMTIADEAQNRYGRKVSWGVEVGGERILFTHIAVPVMTRLKQPERQVLDTLVDAGVARSRSDALAWSVKLVGEHTEEWLAKLRTAMSAVDDLRAQGPDLPA
Protein: Vascular endothelial growth factor C (Q7T3I6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Vascular endothelial growth factor receptor kdr-like
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 3
- receptor protein-tyrosine kinase
- Lymphatic vessel endothelial hyaluronic receptor 1b
- Collagen and calcium-binding EGF domain-containing protein 1
- C-fos induced growth factor
- Angiopoietin-1 receptor
- Platelet-derived growth factor receptor, beta polypeptide
- Neuropilin-1a
Sequence:
MHLFGFSVFCLALFYANLAFESSHDYYEYDQDQADAMQEHSEPDLVEQLRSAGSVDELMRIVYPTYRIMLKCRSKMGSRLLRREPSSTETRSEEASFAAAFINLELLKSIEIEWRKTLCMPRQVCLDVGKEFGATNTFYKPPCVSVYRCGGCCNSEELQCRNISTSYISKTLFEITVPVKQGTKPVTISFANHTSCSCLSKQNLYRQQHSIIRRALTECHVANKTCPKNHSWSNHLCKCVLLPDTLHSKPHSDFETDFCGPDKELDEETCQCECRKELRKAGCGPHHYLDKNTCQCVCKAQPSSCGPQQSFNRDTCQCTCAKVCPRSQPLNRTKCVCECTESPNKCFLKGRRFHPATCSCVRPPCNVDPKRRKCKENEYFSEELCHCIPTYWGRLD
Protein: RecQ-mediated genome instability protein 1 (B3H7H7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MRRRRLQLRYSSDEEEEDETGTSGVGDSVQSFGIASSIQPETSVSSNSNPNPGERIAISEVEIIDVFGNPQPTPPDSSIPTPYPVYPSESVSGNDYESPISEVLSRMGIKLKREWWVSCLSGLETSIPQFSYLDVAAKAKHCFEQFMFFDMNLCGGGVLPPNVASMNRIELAGPFVLQVDEIVNIGCPLKGRYENANAGLKRCLKLSMTDGVQRVFGMEYRPIKDLQVLAPAGLKIVVSSVQVRHGLLMLVPEIVEVLGGMVEELEEARKRLVVEVNKPPRGKSWKDYLQPVCFTDFFGYSFFDLENRDWFGVCLTITRVGVVPSLTTRATLAAWSLNGNDTGNHVHDTGNHVNSSASGNASHTQANQGIPVHVTRTHNSSRAMDEPLASTNVGATVSRVEHMQIDTASAHGERTFSDIHSTSSNIHRAASTAGTGTSCSGACSGARSFANNVGGNSLDQTSNVTSFVEEMHIDTGRVRDTTTHIYGSDSGGVAAEFSNMVVDLEGPSVLSTNTEKPFTYLAELSQKWAVMKDTIHFVQGRIKCFLTGVKKFQFKQQSTYELLCYVDDGSLICEILLHNDVVQKRIGHSSMEVTAALSSSAPTSLNAMMKEKLKRFQLFLADFEGIMVVEMNRSSQYPVAIEMNQGCSLTDARLLLDRIKSSSRTSSSLNPVVVLSP
Protein: Vitellogenin-1 (Vitellogenin I) (Yolk protein 1) (P02843)
Organism: Drosophila melanogaster (Fruit fly)
Function: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis.
Subcellular location: Secreted {ECO:0000305}. Vesicle {ECO:0000269|PubMed:19050045}. Note=Yp1 secreted by fat body cells is taken up by oocytes via clathrin-mediated endocytosis and stored in endocytic derived lysosome-like vesicles called yolk granules. {ECO:0000269|PubMed:19050045}.
Interaction partners:
- Vitellogenin-2
- Vitellogenin-3
- Vitelline membrane protein Vm26Aa
Sequence:
MNPMRVLSLLACLAVAALAKPNGRMDNSVNQALKPSQWLSGSQLEAIPALDDFTIERLENMNLERGAELLQQVYHLSQIHHNVEPNYVPSGIQVYVPKPNGDKTVAPLNEMIQRLKQKQNFGEDEVTIIVTGLPQTSETVKKATRKLVQAYMQRYNLQQQRQHGKNGNQDYQDQSNEQRKNQRTSSEEDYSEEVKNAKTQSGDIIVIDLGSKLNTYERYAMLDIEKTGAKIGKWIVQMVNELDMPFDTIHLIGQNVGAHVAGAAAQEFTRLTGHKLRRVTGLDPSKIVAKSKNTLTGLARGDAEFVDAIHTSVYGMGTPIRSGDVDFYPNGPAAGVPGASNVVEAAMRATRYFAESVRPGNERSFPAVPANSLQQYKQNDGFGKRAYMGIDTAHDLEGDYILQVNPKSPFGRNAPAQKQSSYHGVHQAWNTNQDSKDYQ
Protein: Mannose-1-phosphate guanylyltransferase catalytic subunit beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase 37-kDa subunit) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta) (P0C5I2)
Organism: Sus scrofa (Pig)
Function: Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Y5P6}.
Interaction partners:
Sequence:
MKALILVGGYGTRLRPLTLSIPKPLVDFCNKPILLHQVEALASAGVDHVILAVSYMSQMLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETAEPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLQPTSIEKEIFPVMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQPEQLCSGPGIVGNVLVDPSARIGKNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVCWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPGIIM
Protein: Uncharacterized transcriptional regulatory protein C56F2.05c (O60056)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MDLHSILQPISTPSASVVTAPLPATIALPSPNYYYPPVAQGHYPVNNMWSLPSNVRVISSHGAPGHQTSASQPSTVMPALETNASNAQYYPAYSVINGNNSVQVASPAYTVSHSPHSFSNPRYVAVPQKSTSPNQVCSYCEPLPNHLTKTKSCSIPPILNSSDRSPLSLPTPYPVQYSTQPVSLPQPIAAPAPPSAESSKSTISDEDVAWQLIRLGALSSNSVKSSPSKSFVSISSPVQSTVKPTKASGVVKSEKVEKRSLPPQDFGNASSSTSAKRRRPDHNHTSTLDASSSNTSLASTGPMTVSSSTVERKGKEASEVNPNSTSSVTFSDFAAAISRSRCSRCKKSKKGCDRQRPCGRCRDAGLNSEDCISDDDMPVSNARKPRGRGRGRPKTKN
Protein: Ulbp1 protein (Q3MI26)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
GSFSTLMIILCVIAIAFLGLIFGVSCKLRHLRTKKIGLQSSPPPLLDDSLTVPTSPQSSVCGTMIQCLCPRKLKSPVFMQIDLQSSAPPLLDDSLTVPETCSVKKEDEFPTASQNSVLLTSDDIDGIP
Protein: Phosphodiesterase (EC 3.1.4.-) (A0A8I6AIQ8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTEEVEEYQLSCPQCGEVLFENPEQNVKCVCMLAASSPPPLPMAGQGDVRLRGQTGVPAERRGSYPFIDFRLLNNTTHSGEIGSKKKVRRLLSFQRHFHESRLLRGMTPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLVMVQEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLENIQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGDLEQKFELEISPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTLSESMLNHLAHNKAQWKSLLSNQHRRRGSGQDPAGTAPETLEQTEGATP
Protein: Receptor kinase-like protein Xa21 (EC 2.7.11.1) [Cleaved into: Receptor kinase-like protein Xa21, processed] (Q2R2D5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Receptor kinase that detects X.oryzae pv. oryzae protein Ax21 to promote innate immunity. Following X.oryzae pv. oryzae protein Ax21 detection, undergoes cleavage, releasing the processed protein kinase Xa21 chain.
Subcellular location: [Receptor kinase-like protein Xa21]: Cell membrane {ECO:0000269|PubMed:22735448}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22735448}; Single-pass membrane protein {ECO:0000255}. Note=Present in cortical and perinuclear endoplasmic reticulum. Cleaved upon X.oryzae pv. oryzae protein Ax21 recognition; the kinase containing fragment is translocated into the nucleus. {ECO:0000269|PubMed:22735448}.; SUBCELLULAR LOCATION: [Receptor kinase-like protein Xa21, processed]: Nucleus {ECO:0000269|PubMed:22735448}.
Interaction partners:
- E3 ubiquitin-protein ligase XB3
- Protein phosphatase 2C 35
- Heat shock 70 kDa protein BIP3
- WRKY transcription factor WRKY62
Sequence:
MARSPTSVMISSLLLLLLIGPASSDDAAAAAAARTSTGGVAGDELALLSFKSSLLHQGGLSLASWNTSGHGQHCTWVGVVCGRRRRRHPHRVVKLLLRSSNLSGIISPSLGNLSFLRELDLSDNYLSGEIPPELSRLSRLQLLELSGNSIQGSIPAAIGACTKLTSLDLSHNQLRGMIPREIGASLKHLSNLYLHTNGLSGEIPSALGNLTSLQYFDLSCNRLSGAIPSSLGQLSSSLLTMNLRQNNLSGMIPNSIWNLSSLRAFSVSENKLGGMIPTNAFKTLHLLEVIDMGTNRFYGKIPASVANASHLTQLQIDGNLFSGIITSGFGRLRNLTTLYLWRNLFQTREQEDWGFISDLTNCSKLQTLDLGENNLGGVLPNSFSNLSTSLSFLALDLNKITGSIPKDIGNLIGLQHLYLCNNNFRGSLPSSLGRLRNLGILVAYENNLSGSIPLAIGNLTELNILLLGTNKFSGWIPYTLSNLTNLLSLGLSTNNLSGPIPSELFNIQTLSIMINVSKNNLEGSIPQEIGHLKNLVEFHAESNRLSGKIPNTLGDCQLLRYLYLQNNLLSGSIPSALGQLKGLETLDLSSNNLSGQIPTSLADITMLHSLNLSFNSFMGEVPTIGAFADASGISIQGNAKLCGGIPDLHLPRCCPLLENRKHFPVLPISVSLVAALAILSSLYLLITWHKRTKKGAPSRTSMKGHPLVSYSQLVKATDGFAPTNLLGSGSFGSVYKGKLNIQDHVAVKVLKLENPKALKSFTAECEALRNMRHRNLVKIVTICSSIDNRGNDFKAIVYDFMPSGSLEDWIHPETNDPADQRHLNLHRRVTILLDVACALDYLHRHGPEPVVHCDVKSSNVLLDSDMVAHVGDFGLARILVDGTSLIQQSTSSMGFRGTIGYAAPEYGVGHIASTHGDIYSYGILVLEIVTGKRPTDSTFRPDLGLRQYVELGLHGRVTDVVDTKLILDSENWLNSTNNSPCRRITECIVSLLRLGLSCSQVLPLSRTPTGDIIDELNAIKQNLSGLFPVCEGASLEF