wanglab/gogpt-training-data huggingface dataset:
Protein: Large ribosomal subunit protein uL2 (60S ribosomal protein L8) (P62918)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}.
Interaction partners:
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein eL43
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL33
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL29
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL32
Sequence:
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGTKTVQEKEN
Protein: RFS-1 Interacting Partner (Q21621)
Organism: Caenorhabditis elegans
Interaction partners:
- RAD51-like protein 1
- Helicase POLQ-like
Sequence:
MSESCNSLTVVFTDSPKIDDHLFAKAIRWADQNPDDTIFWARRKALERIPEIDVEFSMKAGALRRIRFGYSSKKLLQGCIDIALKASIGSEVAAIFCSMSIPQDCPELGCLLAALANFCNVDDGRAVVVIDLRDDNDDEKQEGVEESDPFENANFLEEEIVENPKELSNEPRETQTQEEFLEKLKRVASIYTKNVLLFDGNEEKFSNCF
Protein: H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (Q9GTN8)
Organism: Trypanosoma brucei
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU366039}.
Interaction partners:
Sequence:
MTAEISEKAFPLAGDRLTQTILDIVQEASNAKMIKKGANEATKALNRGIADLIVLAGDTNPIEILLHLPLLCEDKNVPYVFVPSKTALGRAAQVSRNAVALAILQMENSPISAKIQAVKLEIERLL
Protein: Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase 1) (Q8K0Z7)
Organism: Mus musculus (Mouse)
Function: Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- Aspartate--tRNA ligase, mitochondrial
- Heme A synthase COX15
- Leucine-rich PPR motif-containing protein, mitochondrial
- Protoheme IX farnesyltransferase, mitochondrial
- Elongation factor Ts, mitochondrial
Sequence:
MMSWAAASLRMTAVPCFRVRCLGFRVGPWGASQHANPGCGAAPHRTLHVSATASAGHNKWSKVRHIKGPKDMERSRIFSKLTLSIRLAVKEGGPNPENNSSLANILELCRSKNMPKSTIESALKTEKNKGIYLLYEGRGPGGSSLLIEALSNSGPKCHLDIKYILNKNGGMMAEGARHFFDKKGVVVVGVEDREKKAVNLERALELAIEAGAEDVKEAEDEEEKNLFKFICDASSLHQVRKKLDSLGLCPVSCSMEFIPHSKVQLAEPELEQAAHLIQALNNYEDVIHVYDNIE
Protein: Camphor resistance CrcB family protein (Expressed protein) (Q8RYE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Uncharacterized protein At3g28850
- Protein S-acyltransferase 8
- Urea-proton symporter DUR3
- Probable inactive receptor kinase At5g58300
- Calcium-dependent protein kinase 8
- FAM10 family protein At4g22670
Sequence:
MDTGQSSIEPYQAKSFSRESSVASSLSLSRSLPHLIDNDVDSESVSEAGDIGDRSLRRRHSAGRSSRLSADDFIEQGTHDTSRQEQDILHDLRAFNTASVNKTLPEDITASPLPTKSLLSPEINNSGKEEERVLPKSLEYISCLIHLAVFGIFGAITRYLLQKLFGPTGARVTSDGSILYLDLPSNMVGSFLMGWFGVVFKADIARVSEFVAIGLSTGYLGSLTTFSGWNQKMLDLSADGQWVYAVLGFLLGLFLTSYSIILGVETAKGFKWLLHRRASSEDKFHCLKVNTFQSHIVSLTLMLLLLVALLTASSILLVKEFDKGTSEAQLWFGCLVAAPGVWLRWFLARLNGRGLGKDSQNLRWVPFGTLIANVVAACVMAALATLKKSVNTRTCNTVASSIQFGLLGCLSTVSTFMAEFNAMRESDYPWRAYAYASFTIVVSFAIGTIIYSVPVWVIGFS
Protein: Solute carrier family 25 member 32 (Mitochondrial FAD transporter) (Q8BMG8)
Organism: Mus musculus (Mouse)
Function: Transports folate across the inner membranes of mitochondria. Can also transport FAD across the mitochondrial inner membrane (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:29666258}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- FAD synthase
- Monofunctional C1-tetrahydrofolate synthase, mitochondrial
- Glycine dehydrogenase
Sequence:
MTGQGQSAAGSAAWSAVFRHVRYENLVAGVSGGVLSNLALHPLDLVKIRFAVSDGLEVRPKYKGILHCLATIWKVDGLRGLYQGVTPNVWGAGLSWGLYFFFYNAIKSYKTEGRAEQLEPLEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYGGVASPSQRQYKGMFDALVKIYKYEGVRGLYKGFVPGLFGTSHGALQFMAYELLKLKYNKHINRLPEAQLSTAEYISVAALSKIFAVAATYPYQVVRARLQDQHVSYGGVTDVITKTWRKEGIGGFYKGIAPNLIRVTPACCITFVVYENVSHFLYDLREKKVS
Protein: Cytochrome b561, DM13 and DOMON domain-containing protein At5g54830 (Protein b561A.tha1) (Q9FFU6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a catecholamine-responsive trans-membrane electron transporter.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- DNA-binding bromodomain-containing protein
- Polyadenylate-binding protein interacting protein
- Protein METABOLIC NETWORK MODULATOR 1
- AT5g54940/MBG8_21
- Large ribosomal subunit protein uL23m
Sequence:
MCDQRPNLLGSLVLLGFFIFFVNGEECSNSSSLIGHESEFKMLQHQLRGVFTVVDDCSFRVSRFDMLSGSEVHWWGAMSSDFDNMTNDGFVISDQKLNQTFKNSSFIVRLLGNVTWDKLGVVSVWDLPTASDFGHVLLSNATESDTSKAESPPSESNDVAPGKSNNSEPFKAPTMFDNCKKLSDKYRLRWSLNAEKGYVDIGLEATTGLLNYMAFGWAKPNSTSNLMLNADVVVTGIREDGFPFADDFYITESSVCSVKEGTATGVCPDTVYEEADSVGSSVNNTKLVYGHRIDGVSFVRYRRPLNDSDNKFDFPVNSTESLTVIWALGVIKPPDVINPYYLPVNHGGVESENFGHFSLNLSDHVDECLGPLDADNKYDQDVIIADAHAPLVVTAGPSVHYPNPPNPSKVLYINKKEAPVLKVERGVPVKFSIEAGHDVSFYITSDFLGGNASLRNRTETIYAGGQETHGVLSSPSELVWAPNRNTPDQLYYHSIFQEKMGWKVQVVDGGLSDMYNNSVNLDDQQVKFFWTIVGDSISIAARGEKKSGYLAIGFGSEMTNSYAYIGWFDRNGTGHVNTYWIDGESASAVHPTTENMTYVRCKSEEGIITLEFTRPLKPSCSHRDRPECKNMIDPTTPLKVIWAMGAKWTDGQLTERNMHSVTSQRPVRVMLTRGSAEADQDLRPVLGVHGFMMFLAWGILLPGGILSARYLKHIKGDGWFKIHMYLQCSGLAIVFLGLLFAVAELNGFSFSSTHVKFGFTAIVLACAQPVNAWLRPAKPAQGELISSKRLIWEYSHSIVGQSAVVVGVVALFTGMKHLGERNGTENVDGLNLALGLWVFLCVVTVAYLEYRERGRRRARNLSRGNWVLGNVEEDDSIDLIDSRGGFRDKDDEDRNGGRMEIQLEPLK
Protein: Major capsid protein 1 (MCP1) (Q914J4)
Organism: Sulfolobus islandicus filamentous virus (isolate Iceland/Hveragerdi) (SIFV)
Function: Self-assembles to form a helical, filamentous nucleocapsid mesuring 1980 nm in length and 24 nm in width. Together with capsid protein 2, wraps arounds the DNA and maintains it in an A-form. Capsid proteins probably maintain the DNA in A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues. This certainly protects the viral DNA under conditions such as the extreme desiccation of its host.
Subcellular location: Virion {ECO:0000269|PubMed:32759221}.
Interaction partners:
Sequence:
MAGRQSHKKIDVRNDTSTRYKGKLYGIFVNYMGEKYAQQLVENMYSNYNDVFVEIYNKMHNALRPTLVKLAGAGATFPLWQLVNEAIYAVYLTHKETASFLVTKYVARGVPAMTVKTLLAEVGNQLKELVPAVAEQIGSVTLDHTNVVSTVDNIVTSMPALPNSYAGVLMKTKVPTVTPHYAGTGTFSSMESAYKALEDIERGL
Protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Complex I-15 kDa) (CI-15 kDa) (NADH-ubiquinone oxidoreductase 15 kDa subunit) (Q02379)
Organism: Bos taurus (Bovine)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:10852722, ECO:0000305|PubMed:18721790}; Peripheral membrane protein {ECO:0000305}. Mitochondrion intermembrane space {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 3
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
Sequence:
MPFFDVQKRLGVDLDRWMTIQSAEQPHKIPSRCHAFEKEWIECAHGIGSIRAEKECKIEFEDFRECLLRQKTMKRLHAIRRQREKLIKEGKYTPPPHHSGQEEPRS
Protein: palmitoyl-protein hydrolase (EC 3.1.2.22) (C0PDF4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAAPVIVEATVKQTATLIFMHGLGDTGHGWSSALAAIRPPFMKVICPTAPTQPVSLNAGFRMPSWFDLKTLDIGGPEDEPGIQSARDSVHGMIQKEISAGIPANRIVLGGFSQGGALALYSALTYDQPLAGVVALSCWLPLHKQFPGAKVNSDDVPIFQAHGDYDPVVPYKFGQLSASLLKSFMKNVTFKTYSGLSHSSSDDEMDDVKDIISKWQQANNHL
Protein: Ethylene-responsive transcription factor RAP2-4 (Ethylene-responsive transcription factor ERF059) (Protein RELATED TO APETALA2 4) (Q8H1E4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pentatricopeptide repeat-containing protein At2g20710
- AT4g32020/F10N7_170
- Low-temperature-induced 78 kDa protein
- Probable peroxygenase 3
- Inactive poly [ADP-ribose] polymerase RCD1
- 2-Cys peroxiredoxin BAS1, chloroplastic
Sequence:
MAAAMNLYTCSRSFQDSGGELMDALVPFIKSVSDSPSSSSAASASAFLHPSAFSLPPLPGYYPDSTFLTQPFSYGSDLQQTGSLIGLNNLSSSQIHQIQSQIHHPLPPTHHNNNNSFSNLLSPKPLLMKQSGVAGSCFAYGSGVPSKPTKLYRGVRQRHWGKWVAEIRLPRNRTRLWLGTFDTAEEAALAYDKAAYKLRGDFARLNFPNLRHNGSHIGGDFGEYKPLHSSVDAKLEAICKSMAETQKQDKSTKSSKKREKKVSSPDLSEKVKAEENSVSIGGSPPVTEFEESTAGSSPLSDLTFADPEEPPQWNETFSLEKYPSYEIDWDSILA
Protein: Peptidyl-prolyl cis-trans isomerase CYP22 (PPIase CYP22) (EC 5.2.1.8) (Cyclophilin of 22 kDa) (Cyclophilin-22) (Q9ZVJ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Interaction partners:
- RNA splicing factor-like protein
- Protein RDM16
- Pre-mRNA-splicing factor
- Pre-mRNA-splicing factor
- Sm-like protein LSM4
- UPF0235 protein At5g63440
- Zinc finger protein ZOP1
- Probable small nuclear ribonucleoprotein F
- Sm protein F
- U4/U6 small nuclear ribonucleoprotein PRP4-like protein
Sequence:
MNSGGGIVAAAAPSSGGGNVEWHVRPPNPKNPVVFFDVSIGGIPAGRIKMELFADIAPKTAENFRQFCTGELRKAGKPLGYKECQFHRVIKDFMVQSGDFLKNDGSGCMSIYGHKFEDENFTAKHTGPGLLSMANSGPNTNGCQFFITCAKCDWLDNKHVVFGRVLGDGLLVMRKIENVAIGPNNRPKLAVVITECGEM
Protein: Glutaryl-CoA dehydrogenase, mitochondrial (EC 1.3.8.6) (A0A8I5ZUK9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
MVPAMLTGYMSLRGVSAWLLSRKLGLRFSRVPRTWSSAAAHTEKTQIRSVKSSRPVFDWKDPLVLEEQLTADEKLIRDTFRNYCQERLMSRILLANRNEVFHRDIVYEMGELGVLGPTIKGYGCAGVSSVAYGLLTRELERVDSGYRSMMSVQSSLVMHPIYTYGSEEQRQKYLPRLAKGELLGCFGLTEPNHGSDPGSMETRARHNPSNKSYTLSGTKTWITNSPVADLFVVWARCEDNCIRGFLLEKGMRGLSAPRIEGKFSLRASATGMIIMDSVEVPEENVLPNVSSLAGPFGCLNTARYGITWGVLGAAEFCLHTARQYALDRYICLPLPPEYWVFITCVIPRATPEMVSLLKRNNCGKALDIARQARDILGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTVEK
Protein: Septin-1 (LARP) (Peanut-like protein 3) (Serologically defined breast cancer antigen NY-BR-24) (Q8WYJ6)
Organism: Homo sapiens (Human)
Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis.
Interaction partners:
- Uncharacterized protein C17orf47
- Septin-11
- Septin-10
- Septin-6
- Septin-5
- Septin-9
- Neuronal-specific septin-3
- Septin-8
- Septin-12
- Septin-7
Sequence:
MAGGVMDKEYVGFAALPNQLHRKSVKKGFDFTLMVAGESGLGKSTLINSLFLTNLYEDRQVPEASARLTQTLAIERRGVEIEEGGVKVKLTLVDTPGFGDSVDCSDCWLPVVKFIEEQFEQYLRDESGLNRKNIQDSRVHCCLYFISPFGRGLRPLDVAFLRAVHEKVNIIPVIGKADALMPQETQALKQKIRDQLKEEEIHIYQFPECDSDEDEDFKRQDAEMKESIPFAVVGSCEVVRDGGNRPVRGRRYSWGTVEVENPHHCDFLNLRRMLVQTHLQDLKEVTHDLLYEGYRARCLQSLARPGARDRASRSKLSRQSATEIPLPMLPLADTEKLIREKDEELRRMQEMLEKMQAQMQQSQAQGEQSDAL
Protein: Gap junction protein (Q8K4M7)
Organism: Cavia porcellus (Guinea pig)
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}.
Interaction partners:
Sequence:
MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCNSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEVKRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCEAHPCPNTVDCFVSRPTEKTIFTVFMLAASGICIILNVAEVVYLIIRACARRAQHRSNPPSRKGSAFGHRLSPEYKQNEINKLLSEQDGSLKDILRRSPGTGAGMAEKSDRCSAC
Protein: Protein RCR2 (Protein SSH5) (Resistance to Congo red protein 2) (Q03446)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- E3 ubiquitin-protein ligase RSP5
- Uncharacterized membrane protein YDL180W
- Protein SSH4
Sequence:
MILREQIDFLIHKRQDDNNNNGEAITDDDPFSSSSWRWGRWIFFIFFIVALLILLFSTAKVNRRRRIMGQAPIRGTAWLTPPTYRQSERDYNGTQRCVEDYVPEYTETANENDLGFYDERGEFHPNGKTEYLAPPPLSEEQASSTDKDLQRPVAAVVRIPSESEFDFNLLRPTMNNFVNGQSNRNEQHSPTVESSSFDVNNAPARAKVSK
Protein: Envelope glycoprotein (Pr80env) (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) (gp70); Transmembrane protein (TM) (Envelope protein p15E); R-peptide (p2E)] (P03385)
Organism: Moloney murine leukemia virus (isolate Shinnick) (MoMLV)
Function: The surface protein (SU) attaches the virus to the host cell by binding to its receptor. Interaction with HECT ubiquitin ligases activates a thiol in a CXXC motif of the C-terminal domain, where the other Cys residue participates in the formation of the intersubunit disulfide. The activated thiol will attack the disulfide and cause its isomerization into a disulfide isomer within the motif. This leads to SU displacement and TM refolding, and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.
Subcellular location: [Transmembrane protein]: Virion membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Host cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the viral envelope, but associates with the virion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [R-peptide]: Host cell membrane {ECO:0000269|PubMed:10516003}; Peripheral membrane protein {ECO:0000269|PubMed:10516003}. Note=The R-peptide is membrane-associated through its palmitate.
Interaction partners:
Sequence:
MARSTLSKPLKNKVNPRGPLIPLILLMLRGVSTASPGSSPHQVYNITWEVTNGDRETVWATSGNHPLWTWWPDLTPDLCMLAHHGPSYWGLEYQSPFSSPPGPPCCSGGSSPGCSRDCEEPLTSLTPRCNTAWNRLKLDQTTHKSNEGFYVCPGPHRPRESKSCGGPDSFYCAYWGCETTGRAYWKPSSSWDFITVNNNLTSDQAVQVCKDNKWCNPLVIRFTDAGRRVTSWTTGHYWGLRLYVSGQDPGLTFGIRLRYQNLGPRVPIGPNPVLADQQPLSKPKPVKSPSVTKPPSGTPLSPTQLPPAGTENRLLNLVDGAYQALNLTSPDKTQECWLCLVAGPPYYEGVAVLGTYSNHTSAPANCSVASQHKLTLSEVTGQGLCIGAVPKTHQALCNTTQTSSRGSYYLVAPTGTMWACSTGLTPCISTTILNLTTDYCVLVELWPRVTYHSPSYVYGLFERSNRHKREPVSLTLALLLGGLTMGGIAAGIGTGTTALMATQQFQQLQAAVQDDLREVEKSISNLEKSLTSLSEVVLQNRRGLDLLFLKEGGLCAALKEECCFYADHTGLVRDSMAKLRERLNQRQKLFESTQGWFEGLFNRSPWFTTLISTIMGPLIVLLMILLFGPCILNRLVQFVKDRISVVQALVLTQQYHQLKPIEYEP
Protein: Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1) (Q99LI9)
Organism: Mus musculus (Mouse)
Function: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
Interaction partners:
- Pre-mRNA cleavage complex 2 protein Pcf11
- General transcription factor IIIC, polypeptide 3
- Cleavage stimulation factor subunit 3
- Cleavage stimulation factor subunit 2
- tRNA-splicing endonuclease subunit Sen2
- Cleavage stimulation factor subunit 2 tau variant
- Cleavage and polyadenylation specificity factor subunit 3
- tRNA-splicing endonuclease subunit Sen54
- Pre-mRNA 3'-end-processing factor FIP1
- Cleavage and polyadenylation specificity factor subunit 2
Sequence:
MSEESNDDKKPTTKFELERETELRFEVEASQSVQLELLAGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSLQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGYGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDVEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK
Protein: Set1/Ash2 histone methyltransferase complex subunit ash-2 (G5EFZ3)
Organism: Caenorhabditis elegans
Function: Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids.
Subcellular location: Nucleus {ECO:0000269|PubMed:20555324}.
Interaction partners:
- Retinoblastoma-binding protein homolog 5
- CXXC-type zinc finger protein 1
- Histone-lysine N-methyltransferase set-2
- JmjC domain-containing protein
- WD repeat-containing protein wdr-5.1
- Dosage compensation protein dpy-30
- PHD-type domain-containing protein
- WD repeat-containing protein wdr-5.3
- Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
- PAX-interacting protein 1
Sequence:
MRSSKGGRGRQAAPKTAPTTVCYCDGKRELGSVEVVCSTCLKWFHGRCLKEFHELNSNGVPFMICYTFTCKQCRPTAEDWKAKKADLVQMCVTVLATLSAERLKADGKLSAEHVPEDFTYLSLKDEIVPYMNENWYMLTAIKQKKEWHQNLAPTLLKEKNIFVQHNDDDDLFALAEKNLSLLGPLHEAVKLIGKRPIERENREPRHIELPPIEGPKTRGASKRRHAEAPVTGKKQKLAADYSSTAAPNGVQIDIPFSKDNYRYYLTEVDPNVPEDPAWNQNQSSAYVIPSFHYRELLNPTVNVSSNDRAFQLSINGNSITGFEGYSMARASHGVSKGTWYFEVNFDDQPDDSHIRIGWSQSYASLQACVGYNKFSYGWRSKHGTKFHEAKGKKYHFGGFKQGDVLGCLIHLPVDKKLQIPANLPSEKYLPVSHKGFNLISFKANYFFEVQEESADIAKTLVEMPGSYIEFFHNGKSCGKAYENIYAGAYYPSISIFKSATATMNLGPKFRNLPRGATGIHARADEQQHEQTLSDMLYLVSKEVNLDHPPRVKREDDDDVKDIKKEIKQEI
Protein: Heterogeneous nuclear ribonucleoprotein U (A0A1W2PPL4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFTLDVKSNTVFDIITDNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVLAGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRGGGGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQSQGYNQWQQGQFWGQKPWSQHYHQGYY
Protein: Probable ATP-dependent RNA helicase DHR2 (EC 3.6.4.13) (DEAH box RNA helicase DHR2) (Helicase JA2) (P36009)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable ATP-binding RNA helicase. Required for 18S rRNA synthesis.
Subcellular location: Nucleus, nucleolus.
Interaction partners:
- U3 small nucleolar RNA-associated protein 14
- ATP-dependent RNA helicase FAL1
- Nucleolar complex protein 14
- U3 small nucleolar RNA-associated protein 5
- Probable ATP-dependent RNA helicase DHR1
- ATP-dependent RNA helicase DBP8
- Essential nuclear protein 1
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- U3 small nucleolar RNA-associated protein 18
- Something about silencing protein 10
Sequence:
MAANSNSRVASNHTSKKQKVRRNIHPFTNNTRIKRASKIVKFNDSGEGDHVSDQRSNKENVLTYKSLKSRASDLLKMRETLPVYQHKREIMSYIESNPVTVLIGETGSGKSTQIPQFVLEKLYDTKKHGSIAVTQPRRVAAINLATRVAQEHGCKLGEQVGYSVRFDNTTTTRTRLKYLTDGMLLRELMMNSDLREYSVIVIDEAHERTVLTDLILGFLKSLIQGPRPDLRIIVMSATLQAEKFSEFFNNAPILFVEGRKFDVKQYYLKAPTDDIVDAVIRCCIQINQGEELGDILCFLPGQEEIDKAVTIMEKIAKYVSDEAPVPLIVPYPLYAALPAVQQSLVFAPIKGFKRKVVFSTNIAETSVTISGVKFVVDSGLRKVKVWRHQLGLATLLTVPISQASAMQRSGRAGRESEGKSFRLYCESDYVKLPKQSEPEIARSDVTSPVLMLKRYGVDDLLNWTWFENPGKEAIVMGLQELYELGALDTRGKITKRGQQMALLPLQPHLSSVLIKASEVGCLSQVIDIVSCLSVENLLLNPSPEERDEVNERRLSLCNAGKRYGDLIMLKELFDIYFYELGKSQDASSERNDWCKGLCISIRGFKNVIRVRDQLRVYCKRLFSSISEEDEESKKIGEDGELISKILKCFLTGFIKNTAIGMPDRSYRTVSTGEPISIHPSSMLFMNKSCPGIMYTEYVFTTKGYARNVSRIELSWLQEVVTNAAAVAKQKVSDSK
Protein: Zinc finger protein JAGGED (Q6S591)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Controls the morphogenesis of lateral organs. Functions in lateral organ shape and is sufficient to induce proliferation and growth of lateral organ tissue. Is necessary and sufficient for bract formation, but its expression is excluded from the cryptic bract, which could be a cause of bractless flowers in Arabidopsis. Participates with FIL and YAB3 in regulating valve margin development. Functions with JGL to define stamen and carpel shape. Functions with AS1 and AS2 in the sepal and petal primordia to repress boundary-specifying genes for normal development of the organs.
Subcellular location: Nucleus {ECO:0000269|PubMed:14973281, ECO:0000269|PubMed:14973282}.
Interaction partners:
- Axial regulator YABBY 3
- Axial regulator YABBY 1
- Protein ASYMMETRIC LEAVES 2
- BEL1-like homeodomain protein 9
- Transcription factor AS1
- Cyclin-dependent kinase inhibitor 4
- Agamous-like MADS-box protein AGL5
- Agamous-like MADS-box protein AGL8
- Protein CUP-SHAPED COTYLEDON 1
- Transcription factor TCP4
Sequence:
MRHEENYLDLNNLPDDFSKDGNKQALEEGSSSGQRKKKGSKEGKDESGKVYECRFCSLKFCKSQALGGHMNRHRQERETETLNQARQLVYRNDTITPPGISPFGYHHTTDPTIYRSVYSSPMIYPGSSSTNLVPQPPMPPPPPPYPYSSNQYSPHNHFNDYYLNPSFRGSRSISPSPNLPTTTTVDYMADSPVEPGYTCVGAPIGPTGFPIRGPSIVRAPLEPPQGRDGDASRQRLDHSLRFPINRFQDHHSL