wanglab/gogpt-training-data huggingface dataset:
Protein: Cation-transporting ATPase catp-5 (EC 7.2.2.-) (Q21286)
Organism: Caenorhabditis elegans
Function: Involved in the uptake and/or transport of polyamines, probably through ATP hydrolysis. This contributes to the maintenance of intracellular polyamine levels. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:19762559}; Multi-pass membrane protein.
Interaction partners:
- MAM domain-containing protein
- MFS domain-containing protein
- Tubulin-specific chaperone A
Sequence:
MNTSEREPLLDTTTRNRVYDTTDNPSTKIMKREKDNPKAKTTSFNQGKLNIGEETCDLYAYKETIGRQILFWLLTIVTLGFYQLLAYWVKSLFVKVRFQPTSHDECEYVMVEDIHGTQTIKEVFKAESDVGLARPTRSGKQEKVKVMRFFTYRKIKYIWYEKDQEWLNPADMDSAAPFNIYQKLTLDVIGLKEQDVIASRKIYNMNALALALTPILVILFKEVLGPFYLFQCFSVALWYSDNYAYYASVIVIITVGSAAVAVYQMRAQEKRIRNMVGDTISVIVRRDGHDITIDASEIVPMDILILPSNTFILPCDCLLMNGTVIVNEAMLTGESVPVTKASLKEADECGPEIRLSSEHNRHTLFSGTTVLQTRNYKGQPVMARVIRTGFSTLKGQLVRSIMYPKPQEKEALKDVMVFILVLGFIALIGFIYTVIEMVSRGESLKHIIIRSLDIITIVVPPALPAAMSVGIINANSRLKKKKIFCTSPTTVNVCGLINVACFDKTGTLTEDGLDFNCLKAIRKNEDGKPEFTSEFEELDPVKLSAENANLNIVVAAASCHSLTRIDGTLHGDPLELILVEKSKWIIEEAVNSDEETQDFDTVQPTVLRPPPEQATYHPENNEYSVIKQHPFNSALQRMSVIISTPSEHSAHDMMVFTKGSPEMIASLCIPDTIPEDYMEVVDEYAQRGFRLIAVASKAVHLNFAKALKTPRDIMESELEFLGLIVMENRLKDVTLSVINELSVANIRCVMVTGDNLLTAMSVARECGIIRPTKKAFLITHSKTEKDPLGRTKLFIKESVSSSENDIDTDSEVRAFDRKAVLRTATYQMAIAGPTYSVITHEYPELVDRITAMCDVYARMAPDQKAQLIGALQEIGAKVSMCGDGANDCAALKAAHAGISLSQAEASIAAPFTSNVPDIRCVPTVIKEGRCALVTSYAVSKYMAAYSLNEFLSVMLLYNDGTNISDGQFLYIDLVLITLVALFLGNTEASRKLSGIPPPRRLATSAFYFSVFGQMFFNIITQTTGYLLVRGQSWYVPNPEELDNTTTMIGTTVFFTSCCMYLGYAFVYSKGHPYRRSVFTNWLLCGIIFVIGAINMVMIFTNMGFLMNLMGFVYVPSTSMRFILLAISLAGVFLSLLYEHFFVEKVVAIHFESYLRQRRLRNGDPSLSAYEKILAAIGSSPRWFEDEINLSKSIDRKETIESKC
Protein: Uncharacterized protein (Q38C96)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Trans-sialidase
- Ribosomal protein S23 mitochondrial conserved domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Rhodanese domain-containing protein
- Uncharacterized protein
- Mitochondrial SSU ribosomal protein
Sequence:
MKSSDIFFAYRLTPVVFKSRQHDSGVNQYGLKPTNAYDYINPTNLINFGRGTTFDNLGVRRAGRGEIDSSPSHSGSPVFTQAKLIGLSGEEQLTMCQSETMALRLCMAKAGKETCERESRALDSCLGRVGHLRRAMSEACWEFNDWFIQNVSDNHTKPFQHRPHDWRHFYAQEKLVRERQQNGHAYGRRPKQFSFGARYVKTDGYGKRPRLPYNK
Protein: Accessory gene regulator protein C (Q2FWM5)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Interaction partners:
- Accessory gene regulator protein B
- Accessory gene regulator protein A
- enoyl-CoA hydratase
Sequence:
MILMFTIPAIISGIKYSKLDYFFIIVISTLSLFLFKMFDSASLIILTSFIIIMYFVKIKWYSILLIMTSQIILYCANYMYIVIYAYITKISDSIFVIFPSFFVVYVTISILFSYIINRVLKKISTPYLILNKGFLIVISTILLLTFSLFFFYSQINSDEAKVIRQYSFIFIGITIFLSILTFVISQFLLKEMKYKRNQEEIETYYEYTLKIEAINNEMRKFRHDYVNILTTLSEYIREDDMPGLRDYFNKNIVPMKDNLQMNAIKLNGIENLKVREIKGLITAKILRAQEMNIPISIEIPDEVSSINLNMIDLSRSIGIILDNAIEASTEIDDPIIRVAFIESENSVTFIVMNKCADDIPRIHELFQESFSTKGEGRGLGLSTLKEIADNADNVLLDTIIENGFFIQKVEIINN
Protein: Homeobox protein CDX-2 (Caudal-type homeobox protein 2) (P43241)
Organism: Mus musculus (Mouse)
Function: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:11729123, ECO:0000269|PubMed:7910823}.
Interaction partners:
- POU domain, class 5, transcription factor 1
- Transcription factor SOX-2
- Transcriptional enhancer factor TEF-3
- Transcription factor GATA-6
- Eomesodermin homolog
- ETS-related transcription factor Elf-5
- Trans-acting T-cell-specific transcription factor GATA-3
- Transcription factor SOX-17
- Transcription factor GATA-4
- Keratin, type I cytoskeletal 20
Sequence:
MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAATANLDSAQSPGPSWPTAYGAPLREDWNGYAPGGAAAANAVAHGLNGGSPAAAMGYSSPAEYHAHHHPHHHPHHPAASPSCASGLLQTLNLGPPGPAATAAAEQLSPSGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERKIKKKQQQQQQQQQQQPPQPPPQPSQPQPGALRSVPEPLSPVTSLQGSVPGSVPGVLGPAGGVLNSTVTQ
Protein: Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) (P62993)
Organism: Homo sapiens (Human)
Function: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:21179510, ECO:0000269|PubMed:37328606}. Cytoplasm {ECO:0000269|PubMed:21179510, ECO:0000269|PubMed:30282717, ECO:0000269|PubMed:37328606}. Endosome {ECO:0000269|PubMed:21179510}. Golgi apparatus {ECO:0000250|UniProtKB:Q60631}.
Interaction partners:
- Receptor tyrosine-protein kinase erbB-4
- Linker for activation of T-cells family member 1
- Lymphocyte cytosolic protein 2
- Insulin receptor substrate 1
- Tyrosine-protein phosphatase non-receptor type 11
- Epidermal growth factor receptor
- Receptor tyrosine-protein kinase erbB-2
- Tyrosine-protein kinase ABL1
- Proto-oncogene vav
- Insulin receptor substrate 2
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Protein: Cyclic nucleotide-binding domain-containing protein (Q381L3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDSRWAASRRVAASQVTVPFGWQLMQYPSATREEVRAIAFAALRRLLYPIARRYIARWYRERVARDMSKEVKMEPLLFRALRQRSVLGSCLKKSNAVDELENNNEQLKRLLDSISYRVYLRGEFIQYSREPSNAVVFVAKGIVKKCSTVSQTRGRVSHDRRLSSSHVEVSITYDDDEGPIVATPSTQCSEKMSVGSIESEALRTQRNTLLSAPTILGECSAVGSFPCTEYLLAESSVVLIGWIPKSAYCTLLGSFPPQIHRSLLMKALETRERLLPHFGCMTCNRMRICPLLVSLSDRDLLQLMEHLVPRVRPAGVQIGEREAPRHIFFIWRGVVCLQQEEAVIPMGGAPPSQPRSRTLFSEGHTFGEWQCMFHEGLGDKFFTLTNVDLYLLPFSVLSSFMKRDQNIRQQIHRAAKVISLTADKCFDGMRFVPPSLDVLKTVVLSPSQVPKLIQRGQGAAGVFSKRVTIANNSIASHVFRPRDNKTDRVNVSPFFIEQLRKMPLVGLCGPHDSFYTDCAARFKLMRYEAGQCIVERGSECNSVILFCQGGAVVVEDEGVVQRNAEGTVQAREWASLPRVPDGSIVGYTCVRRHPWTCSIVAPDDGTEVWELNRVNFVDVLRKHRIERQMHELVLQLMQPLSSVETRDPLLDTQPLLTPSPNSLWSEYRLPNMHPVILSETPRFPIWKEDETMLEATPQWRRSSVV
Protein: Translation machinery-associated protein 16 (Q08687)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ribosome biogenesis protein RLP24
- Nucleolar GTP-binding protein 1
- Bud site selection protein 20
- 60S ribosomal export protein NMD3
- Nucleolar GTP-binding protein 2
- Shuttling pre-60S factor ECM1
- Large subunit GTPase 1
- Ribosome biogenesis protein 15
- Ribosomal RNA-processing protein 15
- Cytoplasmic 60S subunit biogenesis factor REI1
Sequence:
MPVTKSLSKLQKNLSKKGKNITVHPKGRKYEKLVRATMREDKIAAKKKLHQDKRVHELARVKFMQDVVNSDTFKGQPIFDHAHTREFIQSFIERDDTELDELKKKRRSNRPPSNRQVLLQQRRDQELKEFKAGFLCPDLSDAKNMEFLRNWNGTFGLLNTLRLIRINDKGEQVVGGNE
Protein: Neurexin 1, isoform F (A0A0B4KGL0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Neuroligin 3, isoform B
- FI21425p1
- Neuroligin 1, isoform D
- Peripheral plasma membrane protein CASK
- Liprin-alpha, isoform E
- GH07829p
- Molybdenum cofactor synthesis protein cinnamon
- Ephrin
- Contactin
- Bruchpilot, isoform J
Sequence:
MKAPHSATYQDNYADAAMTARTRPSMDMDQQRNRNQAELRLLPAQRTSTSAFESPDLRFNKARRRRRSEQVPPVVVEYRRSYRVLIVSALLVSLAASFVTLSAGFQLDGSQNSFYTFRKWYTGLNGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRNDEQTSLIVDGVSQQRSTKGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGTQFLSYDLGQTGAEPIVSAQDAISFYFRTRQPNGLLFYTGHGTDYLNLALRDGGVSLTMGLANGKQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSSRVYVGGAVNPRALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQCPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQANVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAESNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSETILGRHSTMEIRSVHLGGLFHAEEEIQMTSTMPNFVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTVDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVVPSSLVVSGCEGPTKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFITTRPDAVLLRVESATTQDYMELEIVEGNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVERDPHITIRGDVQLVTGVLDRNDLQRMQQTLNSTRQTPASGYPGALDDLIFSGAGSGCRGDDEDECTPPFESGSGDDLITPVYVPPTKQTTTSQQGNSLSTGGSSSGGVITNGTERACDDEDCVHGSGDYGETTEQFTSTSTARGSESNNEMVTITTTGRSDVTTEQHQGSSSSSSSGSTPSYATTQSSSSSSSGGSAASTPGQVSTTSSVATSSTQRATSSSTSTSSSTTSTTTTTTTTQATPPPEIRSTVTERETTPYDIYIAGGGMGGSGRNDHDRMQLPDEHHPLPPLPPPIPPQDPPPYGPYGGNTYNTNMNNYRPKGKGGRINSIEEERTAMIIGIVAGILIAVVLVILLVLWLKSNGDRGYKTESEKAAAYGSHNPNAALLGNTSTNGSYHQQRQHHMHGGGGGGGAGQQQHHAQQQMHNGHNGNGNGGGGGGGGMMSSGSGSLGYGSDGRPQMAGLVQPKAKKRDSKDVKEWYV
Protein: Basal-body rod modification protein FlgD (P0A1I9)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Required for flagellar hook formation. May act as a scaffolding protein.
Interaction partners:
- Flagellar hook protein FlgE
- Peptidoglycan hydrolase FlgJ
- Flagellar basal body rod protein FlgB
- Flagellar basal-body rod protein FlgG
- Flagellar P-ring protein
- Flagellar hook-length control protein
- Flagellar hook-basal body complex protein FliE
- Flagellar hook-associated protein 3
- Flagellar basal-body rod protein FlgF
- Flagellar M-ring protein
Sequence:
MSIAVNMNDPTNTGVKTTTGSGSMTGSNAADLQSSFLTLLVAQLKNQDPTNPLQNNELTTQLAQISTVSGIEKLNTTLGAISGQIDNSQSLQATTLIGHGVMVPGTTILAGKGAEEGAVTSTTPFGVELQQPADKVTATITDKDGRVVRTLEIGELRAGVHTFTWDGKQTDGTTVPNGSYNIAITASNGGTQLVAQPLQFALVQGVTKGSNGNLLDLGTYGTTTLDEVRQII
Protein: Ferritin (EC 1.16.3.1) (Q9VYH1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ferritin
- Frataxin homolog, mitochondrial
- GEO10752p1
Sequence:
MAWCFRDIRRHMCMLVRQNFAKSCEKKLNDQINMELKASHQYLAMAYHFDRSDISSPGMHRFFLKASVEEREHAEKIMTYMNKRGGLIILSSVPQPLPCFASTLDALKHAMKMELEVNKHLLDLHALAGKEADPNLCDFIEANFLQEQVDGQKILADYISQLEKAQNQVGEFLFDKYMGSGMHPAK
Protein: Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42) (P28698)
Organism: Homo sapiens (Human)
Function: Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.
Subcellular location: Nucleus.
Interaction partners:
- Zinc finger protein 202
- SCAN domain-containing protein 1
- Zinc finger protein 24
- Zinc finger and SCAN domain-containing protein 1
- Plasmalemma vesicle-associated protein
Sequence:
MRPAVLGSPDRAPPEDEGPVMVKLEDSEEEGEAALWDPGPEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALVDGLRREPGGPRRWVTVQVQGQEVLSEKMEPSSFQPLPETEPPTPEPGPKTPPRTMQESPLGLQVKEESEVTEDSDFLESGPLAATQESVPTLLPEEAQRCGTVLDQIFPHSKTGPEGPSWREHPRALWHEEAGGIFSPGFALQLGSISAGPGSVSPHLHVPWDLGMAGLSGQIQSPSREGGFAHALLLPSDLRSEQDPTDEDPCRGVGPALITTRWRSPRGRSRGRPSTGGGVVRGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCSECGRSFSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEEHRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGDPPGPGAKPPAPPGAPEPPGPFPCSECRESFARRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQHRRIHTGERPFACAECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRFSQRLKLTRHQRTHTGEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLTQHRRIHTGERPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQSTKLIQHQRVHSAE
Protein: Os05g0228400 protein (Q75IG3)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVGGMKEEGSMAQAAATAAAAAYSFYGSHLAGDHQHEIQAAAAGGGASNKSQLSQMLMASSPRSCITTSLGSNMLDFSNTAAPPELRSHHHNSDNSSECNSTATGSALKKARVQASSSAQSTLKVRKERLGDRITALHQIVSPFGKTDTASVLQETIGYIRFLLSQIEALSYPYMGDANGTGPMQNGPVGERNPGLFPEYPGQLLNHNGNTGAQQPAAQPEQQGANDDGKKDLRSRGLCLVPVSCTSHFGGDNAADYWAPAPLGGILR
Protein: Uncharacterized protein C18E5.01 (O59681)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MKLVIGTCTDGPVLVFDMETKSITEKLEGVSSPTWVEWEKKSKRLYVANEIEEGYVAVFEWDNGKFSLVDRFTIDGHSPTSLCVLENGSVLTANYNSASISRSKAKDEKPHVWHHEGKSLHPERQTSSHPHQVTAHKHLVCSVDLGLDRFSIFDAEDTSSDPVVVVNVPAGYGPRHIVFHKTLPVCYLICELANRILVYDTNTFECLQDVSTLPPSMTLEKDPKFPQPPSAAEVAVVHDGPFLVASNRYLNHGQCDSLWAARLDPVTGKVIEGTEMQIMLHGICPRHFMFNRGASLLAVAMQDDDLVHVYRREPKSMCLHLLFTIPAPKPTCVKFLEDEDLA
Protein: Cilia- and flagella-associated protein 58 (Coiled-coil domain-containing protein 147) (Q5T655)
Organism: Homo sapiens (Human)
Function: Has an essential role in the assembly and organization of the sperm flagellar axoneme. Required for the elongation of the primary cilium and sperm flagellar midpiece via modulation of the Notch signaling pathway (By similarity).
Subcellular location: Cell projection, cilium {ECO:0000250|UniProtKB:A8HUA1}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:32791035, ECO:0000269|PubMed:33314088}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:B2RW38}. Note=Localized to the entire flagellum and predominantly concentrated in the midpiece. Co-localizes with ODFP2 at the centrosome (By similarity). {ECO:0000250|UniProtKB:B2RW38, ECO:0000269|PubMed:32791035}.
Interaction partners:
Sequence:
MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNKDTAPMDNTFLMVKPNGPGFTGGGFPLRSTKMTF
Protein: Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] (Q9BX67)
Organism: Homo sapiens (Human)
Function: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). Plays a role in angiogenesis. Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15994945, ECO:0000269|PubMed:23255084, ECO:0000269|PubMed:28196865}; Single-pass type I membrane protein {ECO:0000305|PubMed:11590146}. Cell junction {ECO:0000269|PubMed:15994945}. Cell junction, desmosome {ECO:0000269|PubMed:15194813}. Cell junction, tight junction {ECO:0000269|PubMed:28196865}. Note=Detected in the acrosome region in developing spermatids (By similarity). In epithelial cells, it is expressed at desmosomes but not at tight junctions (PubMed:15194813). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (PubMed:15994945). {ECO:0000250|UniProtKB:Q9D8B7}.; SUBCELLULAR LOCATION: [Soluble form of JAM-C]: Secreted {ECO:0000269|PubMed:20592283}.
Interaction partners:
- Integrin beta-2
- Tight junction protein 1
- Integrin alpha-M
- Junctional adhesion molecule B
- Partitioning defective 3 homolog
- Junctional adhesion molecule A
- Immunoglobulin superfamily member 5
- Integrin alpha-4
- Golgi reassembly-stacking protein 2
- InaD-like protein
Sequence:
MALRRPPRLRLCARLPDFFLLLLFRGCLIGAVNLKSSNRTPVVQEFESVELSCIITDSQTSDPRIEWKKIQDEQTTYVFFDNKIQGDLAGRAEILGKTSLKIWNVTRRDSALYRCEVVARNDRKEIDEIVIELTVQVKPVTPVCRVPKAVPVGKMATLHCQESEGHPRPHYSWYRNDVPLPTDSRANPRFRNSSFHLNSETGTLVFTAVHKDDSGQYYCIASNDAGSARCEEQEMEVYDLNIGGIIGGVLVVLAVLALITLGICCAYRRGYFINNKQDGESYKNPGKPDGVNYIRTDEEGDFRHKSSFVI
Protein: Frizzled-7 (Fz-7) (mFz7) (Q61090)
Organism: Mus musculus (Mouse)
Function: Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes. Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:15353129}; Multi-pass membrane protein {ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:15353129}. Endosome membrane {ECO:0000250|UniProtKB:O75084}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O75084}. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. {ECO:0000250|UniProtKB:O75084}.
Interaction partners:
- Protein Wnt-7a
- Protein Wnt-11
- Syndecan-4
- Protein Wnt-5a
- Segment polarity protein dishevelled homolog DVL-1
- Proto-oncogene Wnt-1
- Low-density lipoprotein receptor-related protein 6
- Tyrosine-protein kinase RYK
- Protein Wnt-2
- Low-density lipoprotein receptor-related protein 5
Sequence:
MRGPGTAASHSPLGLCALVLALLGALPTDTRAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTAMSPSDGRGRLSFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFSPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
Protein: Anoctamin (F1M0A0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU280814}.
Interaction partners:
Sequence:
MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSEFCLALGKDKDYMDESEHANYDRSRLLNDFVTKDKPESKTKLSKNDMNYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAVANPDIMFIKVHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSMSRVQKYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEIINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFIKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGIGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQRRKSGQPIHHEWP
Protein: Phosphatidylinositol N-acetyglucosaminlytransferase subunit P-like protein (O80829)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- GPI-anchored adhesin-like protein
- Bifunctional dihydrofolate reductase-thymidylate synthase 2
- Ribonucleoside-diphosphate reductase small chain C
- Putative ribonucleoside-diphosphate reductase small chain B
- Ribonucleoside-diphosphate reductase small chain A
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Bifunctional dihydrofolate reductase-thymidylate synthase 1
- LONGIFOLIA protein
- DNA replication licensing factor MCM5
- Nicotinamide adenine dinucleotide transporter 1, chloroplastic
Sequence:
MEKEICRRHLSREGLGCVWVFMSMFDFRHGGSNQKLLMDKKRRSKRIIIGNNGVFETKVEKQLTCDCDCDEESEAEMQSVKKLIEAEIDEKTTQKCEARNRKRRSRTCSKISEDINVLIAGDDDDDHAEKSDNECPIVSHNEVDMVNDDSEEKFSELIKRLIAQKESEVESCKKNLVDAFQVLDSKEESLNIGTPTSGDSQRIKETQTIVILKPEPNTLDVGSSPGTPSTDNKAKNEKFSSRFSLSRIRRRLKFAVGKNPCNAQHDSDPDPDADALSSSMSQNCCLGEEIETNPGSDGEILPDIASKGEANKEDTFHESEKDSKKSMCGIYIAAKKHLSEMLAEGDIDADLPDKEVPRILGKILALPEFFTPENSPRVTLALDHQIIEKPNIQQCSSKDYYYEPLRLDSNNHEETEFMPVPEDTRMEEEEQTVMDSLSEAISSSIIQQDAYIDEDEHKQLLEKEVLKEGQSPCSPPNSSVRMSECQENTTDVLGKSSPVSVLEPFFTDDDTSPNSSRFSSAEMRMQPLCIRFDEPDFPGPEKDNDVKTRMDDKELALEYIQAVVKSSELNWEELLARSFYSEKILEQALMDDIDFCSTNLCSDKKLLFDCINEVLMEFCGHGPWISFVKPAMHFFPDMENAVEVVQEEVYWHLLPLPSPHTLDQIVRKDLARTGNWMDLRFDIGCIVSETGEIILDELLEEIISNCRDLVQPERINKLVP
Protein: Zinc finger protein 136 (P52737)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MDSVAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIGKKWKDQNIKDHYKHRGRNLRSHMLERLYQTKDGSQRGGIFSQFANQNLSKKIPGVKLCESIVYGEVSMGQSSLNRHIKDHSGHEPKEYQEYGEKPDTRNQCWKPFSSHHSFRTHEIIHTGEKLYDCKECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGEKPYECQECGKAFTCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQVHERIHTGEKPFKCKQCGKAFSCSPTLRIHERTHTGEKPYECKQCGKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEGPYKCKVCGKPFHSLSPFRIHERTHTGEKPYVCKHCGKAFVSSTSIRIHERTHTGEKPYECKQCGKAFSYLNSFRTHEMIHTGEKPFECKRCGKAFRSSSSFRLHERTHTGQKPYHCKECGKAYSCRASFQRHMLTHAEDGPPYKCMWESL