wanglab/gogpt-training-data huggingface dataset:
Protein: TMV resistance protein N (EC 3.2.2.6) (Q40392)
Organism: Nicotiana glutinosa (Tobacco)
Function: Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MASSSSSSRWSYDVFLSFRGEDTRKTFTSHLYEVLNDKGIKTFQDDKRLEYGATIPGELCKAIEESQFAIVVFSENYATSRWCLNELVKIMECKTRFKQTVIPIFYDVDPSHVRNQKESFAKAFEEHETKYKDDVEGIQRWRIALNEAANLKGSCDNRDKTDADCIRQIVDQISSKLCKISLSYLQNIVGIDTHLEKIESLLEIGINGVRIMGIWGMGGVGKTTIARAIFDTLLGRMDSSYQFDGACFLKDIKENKRGMHSLQNALLSELLREKANYNNEEDGKHQMASRLRSKKVLIVLDDIDNKDHYLEYLAGDLDWFGNGSRIIITTRDKHLIEKNDIIYEVTALPDHESIQLFKQHAFGKEVPNENFEKLSLEVVNYAKGLPLALKVWGSLLHNLRLTEWKSAIEHMKNNSYSGIIDKLKISYDGLEPKQQEMFLDIACFLRGEEKDYILQILESCHIGAEYGLRILIDKSLVFISEYNQVQMHDLIQDMGKYIVNFQKDPGERSRLWLAKEVEEVMSNNTGTMAMEAIWVSSYSSTLRFSNQAVKNMKRLRVFNMGRSSTHYAIDYLPNNLRCFVCTNYPWESFPSTFELKMLVHLQLRHNSLRHLWTETKHLPSLRRIDLSWSKRLTRTPDFTGMPNLEYVNLYQCSNLEEVHHSLGCCSKVIGLYLNDCKSLKRFPCVNVESLEYLGLRSCDSLEKLPEIYGRMKPEIQIHMQGSGIRELPSSIFQYKTHVTKLLLWNMKNLVALPSSICRLKSLVSLSVSGCSKLESLPEEIGDLDNLRVFDASDTLILRPPSSIIRLNKLIILMFRGFKDGVHFEFPPVAEGLHSLEYLNLSYCNLIDGGLPEEIGSLSSLKKLDLSRNNFEHLPSSIAQLGALQSLDLKDCQRLTQLPELPPELNELHVDCHMALKFIHYLVTKRKKLHRVKLDDAHNDTMYNLFAYTMFQNISSMRHDISASDSLSLTVFTGQPYPEKIPSWFHHQGWDSSVSVNLPENWYIPDKFLGFAVCYSRSLIDTTAHLIPVCDDKMSRMTQKLALSECDTESSNYSEWDIHFFFVPFAGLWDTSKANGKTPNDYGIIRLSFSGEEKMYGLRLLYKEGPEVNALLQMRENSNEPTEHSTGIRRTQYNNRTSFYELING
Protein: Early growth response protein 1 (EGR-1) (Zinc finger protein ZENK) (O73693)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity). Plays role in regulating the expression of circadian clock genes (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P18146}. Cytoplasm {ECO:0000250|UniProtKB:P18146}.
Interaction partners:
- Mitogen-activated protein kinase
- Protein c-Fos
- Dual specificity protein phosphatase
- Dual specificity protein phosphatase
Sequence:
CDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKVEKAAPASTASPIPAYSSSVTTSYPSSITTTYPSPVRTAYSSPAPSSYPSPVHTTFPSPSIATTYPSGTATFQTQVATSFSSPGVANNFSSQVTSALSDINSAFSPRTIEIC
Protein: PALM2-AKAP2 fusion protein (A-kinase anchor protein 2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL) (Paralemmin A kinase anchor protein) (Paralemmin-2) (Protein kinase A-anchoring protein 2) (PRKA2) (O54931)
Organism: Mus musculus (Mouse)
Function: Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:9497389}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:9497389}; Cytoplasmic side {ECO:0000269|PubMed:9497389}. Note=Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons. {ECO:0000269|PubMed:9497389}.
Interaction partners:
- Paralemmin-2.
- Paralemmin-1
- A-kinase anchor protein 1, mitochondrial
Sequence:
MAEAELHKERLQAIAEKRKRQTEIEGKRRQLDEQVLLLQHSKSKVLREKWLLQGVPAGTAEEEEARRRQSEEDEFKVKQLEDNIQRLEQEIQALESEESQISAKEQIILEKLKETEKSFKDLQKSFSTADGASGWSTVLLQGDELTADPIGTNADMAIQKPPQLSEDANQLRSKQDNCGDSRLEPAASSLSPDHKNMEIGVSVAECKSVPGVTSTPHSKDHSSPFYSPSHNGLLADHHESLDNDVAREIQYLDEVLEANCCDSSVDGTYNGISSPEPGAAILVSSLGSPAHSVTEAEPTEKASGRQVPPHIELSRSPSDRMAEGERANGHSTDQPQDLLGNSLQAPASPSSSTSSHCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEEDEREKEQFCVRKVRPSEEMIELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHRKYKERKEKRAQQEQLQLQQQQQQQLQQQQLQQQQLQQQQLQQQLQQQQLSTSQPCTAPAAHKHLDGIEHTKEDVVTEQIDFSAARKQFQLMENSRQTLAKGQSTPRLFSIKPYYKPLGSIHSDKPPTILRPATVGGTLEDGGTQAAKEQKAPCVSESQSAGAGPANAATQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDEDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETPSALQENSLADFSLPQTPQTDNPSEGREGVSKSFSDHGFYSPSSTLGDSPSVDDPLEYQAGLLVQNAIQQAIAEQVDKAEAHTSKEGSEQQEPEATVEEAGSQTPGSEKPQGMFAPPQVSSPVQEKRDILPKNLPAEDRALREKGPSQPPTAAQPSGPVNMEETRPEGGYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVRQSTPSPRAKNAPSLPSRTTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSYTSKLLSCKVTSEVLEATRVNRRKSALALRWEAGIYANQEEEDNE
Protein: Protein crooked neck (P17886)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in pre-mRNA splicing process. Involved in embryonic neurogenesis and cell rearrangement during Malpighian tubule morphogenesis.
Subcellular location: Nucleus speckle. Note=Concentrated in nuclear speckles.
Interaction partners:
- Protein BUD31 homolog
- Pre-mRNA-splicing factor Syf2
- RE31520p
- Puff-specific protein Bx42
- Pre-mRNA-splicing factor syf1 homolog
- Pre-mRNA-splicing factor RBM22
- Cell division cycle 5, isoform A
- 116 kDa U5 small nuclear ribonucleoprotein component
- Pleiotropic regulator 1
- Pre-mRNA-processing factor 19
Sequence:
MERPQKMPKVAKVKNKAPAEVQITAEQLLREAKERDLEILPPPPKQKISDPAELADYQQRKRKTFEDNLRKNRMVVSHWIKYAQWEEQQQEIQRARSIWERALDNEHRNVTLWLKYAEMEMKNKQVNHARNLWDRAVTIMPRVNQFWYKYTYMEEMLENVAGARQVFERWMEWQPEEQAWQTYVNFELRYKEIDRAREIYERFVYVHPDVKNWIKFARFEESHGFIHGSRRVFERAVEFFGDDYIEERLFIAFARFEEGQKEHDRARIIYKYALDHLPKDRTQELFKAYTKHEKKYGDRAGIEDVIVSKRKYQYEQEVAANPTNYDAWFDYLRLIEAEGDRDQIRETYERAISNVPPANEKNFWRRYIYLWINYALYEELEAEDAERTRQIYKTCLELIPHKQFTFSKLWLLYAQFEIRCKELQRARKALGLAIGMCPRDKLFRGYIDLEIQLREFERCRMLYEKFLEFGPENCVTWMKFAELENLLGDTDRARAIFELAVQQPRLDMPELLWKAYIDFEVALGETELARQLYERLLERTQHVKVWMSFAKFEMGLSHGDSGPDAELNVQLARRIYERANEMLRQLGDKESRVLLLEAWRDFERDASDSQEMQKVMDKMPRRIKKRQKIVSDNGVEEGWEEVFDYIFPEDEMARPNLKLLAAAKMWKTQKDNTVDDPPATAIASEPEPAADAAPADTTDSGD
Protein: E3 ubiquitin-protein ligase XBAT33 (EC 2.3.2.27) (Ankyrin repeat domain and RING finger-containing protein XBAT33) (Protein XB3 homolog 3) (RING-type E3 ubiquitin transferase XBAT33) (Q4FE45)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses E3 ubiquitin-protein ligase activity when associated with the E2 enzyme UBC8 in vitro.
Interaction partners:
- Putative E3 ubiquitin-protein ligase XBAT35
- Putative E3 ubiquitin-protein ligase XBAT34
- Transcription factor Pur-alpha 1
- 40S ribosomal protein
- DNA replication licensing factor MCM3
Sequence:
MGNSFGCSASGERLVSAARDGDFVEAKMLLDCNPCLAKYSTFGGLNSPLHFAAAKGHNEIVGLLLENGADVNSRNYCGQTALMQACRYGHWEVVQTLLLFRCNVTRADYLAGRTALHFAAVNGHARCIRLVLADFLPSDKLNSLPETGVVTAKNKSEQSALSKFVNKAADGGITALHMAALNGLFDCVQLLLDLEANVSAVTFHYGTSMDMIGAGSTPLHYAACGGNLKCCQILLARGARKMTLNCNGWLPIDIARMWSRHWLEPLLSPNSDVVIPAFPHSNYLSLPLLSILNIAREFGLQSATIGDEVDICAVCLERTCTVAAEGCEHQLCVRCALYLCSSSNVPSVTVGPPGSIPCPLCRHGITAFKRLPSSLTREMKLPMSLGFCAPCMLHTGDTTDQSSPTCPPTEQRSSKTRAASVSSDIFCPVTCSPFPSVNIPMCTCNEGTCPNFETHGTERHSEEHVESSPSRTTTEQEKIEEGQRLGKTTTCSSMFWGRRSCSRENQCNSEINA
Protein: Calcyphosin (Calcyphosine) (Q13938)
Organism: Homo sapiens (Human)
Function: Calcium-binding protein. May play a role in cellular signaling events (Potential).
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MQCHRDLALSQALWGWQLSKQSGWAHPSLPHSPLPSTVHSCSWAPPHLQRHLPLATVSPGTTQLTQGPAGRTLGQTQASCPEPRPSMDAVDATMEKLRAQCLSRGASGIQGLARFFRQLDRDGSRSLDADEFRQGLAKLGLVLDQAEAEGVCRKWDRNGSGTLDLEEFLRALRPPMSQAREAVIAAAFAKLDRSGDGVVTVDDLRGVYSGRAHPKVRSGEWTEDEVLRRFLDNFDSSEKDGQVTLAEFQDYYSGVSASMNTDEEFVAMMTSAWQL
Protein: Thiamine transporter thi9 (Q9UT18)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Thiamine transporter involved in the cellular uptake of thiamine. Pyrithiamine, oxythiamine, amprolium, and the thiazole part of thiamine have been shown to be also substrates of thi9.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Vitamin B6 transporter bsu1
- Eukaryotic translation initiation factor 5B
- Thiamine repressible genes regulatory protein thi5
- Probable urea active transporter 1
- Thiamine thiazole synthase
- Thiamine pyrophosphokinase
Sequence:
MPSSQISHQDPELGQTSSGSSSIKEKAEPQLYAGPIDPARRPDVFQEGFEDVSVTDDDNDNELLRKMGYQPVLHRSFEFFESFAASFASLDVVSGVRLTFSWGISFGGPAAYWSAMLVTGFCSIVTAACLAEICSALPAAGSIYLWAAESAGPRFGRFVSFLVAWWSTTAWTTFVASITQSTANFIFAEVSTFNNPWPTNDSDVKFRAVQWIVAEVLLVFTILLNQVPPRYYKWIFKASMLLMFIDYVMNIIWVPVATSKKPDGFRSAKWVFTETIYDQAGYIKEVDDANGNPIASLSKIVPKGWQWCLSYFATAGVIVGYDASGHIAEETKDASIKAARGIFYSTVTSFIVAFSLAILYLFCCPDLDTFTAILYNDNSPQPFVNFYSYLLGRGGHVVMNVVIILEIFLNGVVSVLACSRLVFAVSRDGVLPFSNWISQVSKTGQPKNAITVIYIVSALLLCTILPSAVAFTSLVSAAGAPSFAAYAVLAFCRLFITRDKFPKGRWSLGWLSKPCLVITLVYNLFALVVNVSPYTYPVTGPSFNYAVVIMGGVSIFAIICTIVIPKSRWVANRYRYESDSEHSASVKELKV
Protein: SAP domain-containing ribonucleoprotein (Nuclear protein Hcc-1) (Q9D1J3)
Organism: Mus musculus (Mouse)
Function: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}.
Interaction partners:
- Spliceosome RNA helicase Ddx39b
- Chromatin target of PRMT1 protein
- ATP-dependent RNA helicase DDX39A
- THO complex subunit 4
- Aly/REF export factor 2
- UAP56-interacting factor
- THO complex subunit 1
- Polymerase delta-interacting protein 3
- THO complex subunit 7 homolog
- THO complex subunit 3
Sequence:
MAAETVELHKLKLAELKQECLARGLETKGIKQDLINRLQAYLEDHAEEEANEEDVLGDETEEEEPKPIELPVKEEEPPEKAVDMASEKKVVKITSGIPQTERMQKRAERFNVPVSLESKKAARAARFGISSVPTKGLSSDTKPMVNLDKLKERAQRFGLNVSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDTEAKKRKRAERFGIA
Protein: Suppressor of variegation 2-10, isoform G (A1Z7P8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPFPSLQECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLELLAPKVQEVYAQSVQEQNATLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSETVDLTLSDSDDDMPLAKRRPPAKQAVASSTSNGSGGGQRAYTPAQQPQQSESPEQQASRQSPEKQTVSEQQLQQQQHEQPATAAVHASLLESLAAAVADQKHFQLLDLAAVAAAAAATASSGQSQNAGP
Protein: Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) (Q9JKC9)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (By similarity). May act by linking the adapter protein complex AP-1 to other proteins (By similarity). Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10477754}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10477754}; Peripheral membrane protein {ECO:0000269|PubMed:10477754}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9UMZ2}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q9UMZ2}. Note=Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin (By similarity). Associates with membranes via the adapter protein complex AP-1 (PubMed:10477754). Colocalizes with AP1G1 (PubMed:10477754). {ECO:0000250|UniProtKB:Q9UMZ2, ECO:0000269|PubMed:10477754}.
Interaction partners:
- Aftiphilin
- AP-2 complex subunit sigma
- Epsin-2
- Clathrin heavy chain 1
- AP2-associated protein kinase 1
- Clathrin light chain B
- Clathrin light chain A
- Sodium channel and clathrin linker 1
- Sodium channel protein type 10 subunit alpha
- Leucine-rich repeat neuronal protein 3
Sequence:
MALRPGAGASGAAGAGTGPGGAGSFMFPVAGGMRPPQGLIPMQQQGFPMVSVMQPNMQGMMGMNYSSQMSQGPIAMQAGIPMGPMPAAGVPFLGQPPFLGMRPAAPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKNRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPDCPTSSHSTKTVSPSSAFLGEDEFSGFMQGPVELPTCGPSSTAQPFQSFLPSTPLGQLHTQKAGAQPLPPGQAPVSFAVHGVHGQIPCLSAASASHSMQKAGPSLEEKLLVSCDISASGQEHIKLSSPEAGHRAVVPGSSKNSPGLMAHNGGAVDGCVSGPTTAVAEKTSDQNLSKEESGVGVFPSQDPVQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGKLTKEELYTVLAMVAVTQRGVPAMSPDTLNQFPAAPIPTLSGFPMTLPTPVSQPTAMTSGPAGSIPLSLGQPIMGINLVGPVGGAAAPTSSGFMPAYPSNQVGKTEEDDFQDFQDASKSGSIDDSFTDFQEVPASSKTSNSQHGNSAPSLLIPLPGTKASTDKYAVFKGISAEKPSENPASFGESGDKYSAFRELEPTADSKPLGESFAEFRSTGTDDGFTDFKTADSVSPLEPPTKDSFPSAFASGAAQQTQTQVKTPLNLADLDMFSSVDCSGEKPVPFSAAFSTSKSVSSRPQPAGSAAAPASLASTKASSLADDFGEFNLFGEYSNPASVGEQDDFADFMAFGNSSIPSEPKADDKYEALREEGSPGALSTSTVEGAHNPPVSSSKYDVFKQLSLEGAGLAIEEFKENTPSTKSDGDFADFHSSKFSSTSSDKSLGEKAVAFRHAKEDSASVKSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPAAGSALASEDALPETPFPAFASFKDMMPQTTEQKEYESGDFQDFTRQDMPMVDRSQENTCPSPASSVASHETPKEGADDFGEFQSEKPKISKFDFLVANSQSKMKSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLSERAALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALDVIKKANDTLNGISSSAVCTEVIQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQLLKDIDKVWNNLIGFMSLTTLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEETPAEEQPKKAFNSETDSFKLAYGGHQYHASCANFWINCVEPKPPGLLLPDLL
Protein: 60 kDa lysophospholipase (LysoLP) (EC 3.1.1.5) (Lysophospholipase-transacylase) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase)] (Q86U10)
Organism: Homo sapiens (Human)
Function: Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity).
Interaction partners:
- Isoaspartyl peptidase/L-asparaginase
- Threonine aspartase 1
- Asparagine synthetase
Sequence:
MARAVGPERRLLAVYTGGTIGMRSELGVLVPGTGLAAILRTLPMFHDEEHARARGLSEDTLVLPPASRNQRILYTVLECQPLFDSSDMTIAEWVCLAQTIKRHYEQYHGFVVIHGTDTMAFAASMLSFMLENLQKTVILTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRATKVDARRFAAFCSPNLLPLATVGADITINRELVRKVDGKAGLVVHSSMEQDVGLLRLYPGIPAALVRAFLQPPLKGVVMETFGSGNGPTKPDLLQELRVATERGLVIVNCTHCLQGAVTTDYAAGMAMAGAGVISGFDMTSEAALAKLSYVLGQPGLSLDVRKELLTKDLRGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQAPCPEVLPGV
Protein: Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) (P9WFW1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Valine--tRNA ligase
- Uncharacterized tRNA/rRNA methyltransferase Rv3579c
- Arginine--tRNA ligase
- Serine acetyltransferase
- Threonine--tRNA ligase
- Glutamate--tRNA ligase
- Leucine--tRNA ligase
- Serine--tRNA ligase
- Isoleucine--tRNA ligase
- Histidine--tRNA ligase
Sequence:
MTDRARLRLHDTAAGVVRDFVPLRPGHVSIYLCGATVQGLPHIGHVRSGVAFDILRRWLLARGYDVAFIRNVTDIEDKILAKAAAAGRPWWEWAATHERAFTAAYDALDVLPPSAEPRATGHITQMIEMIERLIQAGHAYTGGGDVYFDVLSYPEYGQLSGHKIDDVHQGEGVAAGKRDQRDFTLWKGEKPGEPSWPTPWGRGRPGWHLECSAMARSYLGPEFDIHCGGMDLVFPHHENEIAQSRAAGDGFARYWLHNGWVTMGGEKMSKSLGNVLSMPAMLQRVRPAELRYYLGSAHYRSMLEFSETAMQDAVKAYVGLEDFLHRVRTRVGAVCPGDPTPRFAEALDDDLSVPIALAEIHHVRAEGNRALDAGDHDGALRSASAIRAMMGILGCDPLDQRWESRDETSAALAAVDVLVQAELQNREKAREQRNWALADEIRGRLKRAGIEVTDTADGPQWSLLGGDTK
Protein: Large ribosomal subunit protein eL18 (60S ribosomal protein L18) (P35980)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q07020}. Cytoplasm {ECO:0000269|PubMed:36517592}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q95342}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q07020, ECO:0000250|UniProtKB:Q95342}.
Interaction partners:
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein eL8
- Small ribosomal subunit protein uS13
- Small ribosomal subunit protein eS17
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein eL30
Sequence:
MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTVTDDVRILEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALESPKGRGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN
Protein: Interferon gamma (IFN-gamma) (Q1KMD4)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|PIRNR:PIRNR001936}.
Interaction partners:
Sequence:
MTCQTYNLFVLSVIMIYYGHTASSLNLVQLQDDIDKLKADFNSSHSDVADGGPIIVEKLKNWTGRNEKRIILSQIVSMYLEMLENTDKSKPHIKHISEELYTLKNNLPDGVKKVKDIMDLAKLPMNDLRIQRKAANELFSILQKLVDPPSFKRKRSQSQRRCNC
Protein: Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) (P38400)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell membrane {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:P04899}; Lipid-anchor {ECO:0000250|UniProtKB:P04899}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody (By similarity). {ECO:0000250}.
Interaction partners:
- Lysophosphatidic acid receptor 1
- D
- Guanine nucleotide-binding protein G
- G protein subunit beta 4.
- G protein signaling modulator 1.
- Adenosine receptor A3
- Sphingosine-1-phosphate receptor 3
- G_PROTEIN_RECEP_F1_2 domain-containing protein
- Uncharacterized protein
- Adenylate cyclase type 6
Sequence:
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFDDPSRADDARQLFALSCTAEEQGVLPEDLSCVIRRLWADNGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYEEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Protein: Sister chromatid cohesion protein DCC1 (Defective in sister chromatid cohesion protein 1 homolog) (Q9BVC3)
Organism: Homo sapiens (Human)
Function: Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Replication factor C subunit 2
- Chromosome transmission fidelity protein 8 homolog
- Replication factor C subunit 5
- Chromosome transmission fidelity protein 18 homolog
- Replication factor C subunit 3
- Replication factor C subunit 4
- DNA polymerase epsilon catalytic subunit A
- Structural maintenance of chromosomes protein 3
- N-acetyltransferase ESCO2
- N-acetyltransferase ESCO1
Sequence:
MKRTRDEVDATLQIAKLNAAELLPAVHCLGFGPGASGAAAGDFCLLELEPTLCQQLEDGHSLVIRGDKDEQAVLCSKDKTYDLKIADTSNMLLFIPGCKTPDQLKKEDSHCNIIHTEIFGFSNNYWELRRRRPKLKKLKKLLMENPYEGPDSQKEKDSNSSKYTTEDLLDQIQASEEEIMTQLQVLNACKIGGYWRILEFDYEMKLLNHVTQLVDSESWSFGKVPLNTCLQELGPLEPEEMIEHCLKCYGKKYVDEGEVYFELDADKICRAAARMLLQNAVKFNLAEFQEVWQQSVPEGMVTSLDQLKGLALVDRHSRPEIIFLLKVDDLPEDNQERFNSLFSLREKWTEEDIAPYIQDLCGEKQTIGALLTKYSHSSMQNGVKVYNSRRPIS
Protein: Phosphate transporter PHO1 homolog 5 (Protein PHO1 homolog 5) (AtPHO1;H5) (Q6R8G5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May transport inorganic phosphate (Pi).
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- AT5g37540/mpa22_p_70
- AT4g33900 family protein)
- At1g13195
- Extracellular ligand-gated ion channel protein
- Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC
- 1,4-dihydroxy-2-naphthoyl-CoA thioesterase 1
- Duplicated homeodomain-like superfamily protein
- SPX domain-containing protein 4
- Receptor like protein kinase S.2
- GDSL esterase/lipase At4g10955
Sequence:
MKFGKEFSSQMVPEWHEAYMDYDYLKSQLKEIIKFKRKTNPHGPHHHHHHLLHRKMTLHRAFSGLISTSPKKKKHHGHGGGHGGGHQIGHFSDSDDDIEEGIKHVTAPILINSASHGYETTFLMASEEGGEYETVFFRRLDDEFNKVEKFYKEKVEEVMKEAVMLEKQMDALIAFRVKVEHPDGWPWEERTVEMTQLASDVANSAAAVAASTPAGARSMKVGAQAHMEAIQEGGSSKAGKSSDEEDDDDAEKEEDNGVSGEVSGDVRKMKAGRPPPIEVLDRVKFNHTKETPRSTIKSVLQASNLTELKFSRENLRKVEAKLRRAFVEFYQKLRLLKSYSFLNELAFSKILKKYDKITSRHASKSYMKMIDNSYLGSSDEVTRLVERVEATFIKHFSNANRSKGMNILRPKAKRERHRITFSTGFLGGCLFSLVVALFAIIRTRNILQEEGQKQYMNTMFPLYSLFGFVVLHILMYAGNIYYWRRYRVNYSFIFGFKHGTELGYRQVLFVGLSIGVFALLCILANLDMEVDPETKDYQALTELLPLFLLTGMFVVLVLPFNIFYRSSRFFFLTCLFHCLAAPLYKVTLPDFLVGDQLTSQVQALRSIQFYICHYGWGDYKHRINTCTESDAYNAFLFIVAVIPYVSRLLQCLRRLFEEKNPEQGYNGLKYFLTIVAVCLRTTYSVDEDNQFIWRILAGIFSAIAAIFCTYWDLVYDWGLLNRTSKNPWLRDKLLVPQKKVYFIAMILNILLRFAWLQTVLDFNFSFMHRQTMVAVVASLEIIRRGIWNFFRLENEHLNNVGKYRAFKTVPLPFNYDEDDDKGN
Protein: Centriolar coiled coil protein 110kDa, isoform A (Centriolar coiled coil protein 110kDa, isoform C) (Centriolar coiled coil protein 110kDa, isoform E) (Centriolar coiled coil protein 110kDa, isoform G) (GH03511p) (Q9VR58)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDATWAMEQLLSAVEMGGSHSEATTPTATTTISIWSAPSEGSGSSSMDPVSFRFHLDGQPILPPLMTSAKKREVQLARQMAEALEKRYRLARHSAGSDMASRRSVSQLQQTETLIYDSTRGQARPQTLVFGKQLPTIQVDPPTPQPFVKSIENTSPRRHNRITDRILQFEQSGLGKLLPKVPDKCILRTSPAVAEDQQDQDTKDTTARELGSPLAEPANFQRSRSFTLEEPSQVLVEHMEREALAVKPSQSLANFEKQTIESQAKRVNRSARSISSKISHNSYNSNSSAATKSTIATKTTTAGSSCSRRDREVERIIERALDEHGALEASRKAGVRNYLRGHRERMNQLVIHQEKERRRMQAEFDHQQRQLIEELCAEIDVSSATENPDSLISQSTSTGDLQRFSPSPTLPSFSEDIEDFPTMEDKCQIAGPSSARKRLFSPKPSKDSEPQLLSAPSTPRSLPLRNSSLTNSRRSVQVVRRRSQSVGGSLVKTITAADREVKKSPAKPGGGAGRPKSSPGKNSSIIAKRGSAPPKSASPTKRLGNRKKP