wanglab/gogpt-training-data huggingface dataset:
Protein: Longitudinals lacking protein, isoform G (P42283)
Organism: Drosophila melanogaster (Fruit fly)
Function: Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
Subcellular location: Nucleus {ECO:0000269|PubMed:8050351}.
Interaction partners:
- Modifier of mdg4
Sequence:
MDDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQYDKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPESSGHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMENDAHDNSNSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKTESAKLTSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQSQGGAQGVQGDDEDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTYATWQHDRSQDELGLMAQDAQQRDPQDLSRKENTAPDVASTAEIQRSFQRSILNGKQRDEQKIQLPGSRRKRLSVTEVSDMLFEFYKTKSAKVPKAEQPHRQVSPTSGEILDPSTISAIAVYGTASETASKNLNADEVMRVQNATATRVVGAAAGAAASFHPRPKYTLKTAASSTEHTTAIPTSVLVANSAAALTPKPQAAVIAEALMRNGLHNFQQQLRAQEILRQQTPHRRIKEENDVEIAGGDITPTKILENLLRKQQERDLRHSECENEPGYSTEDDEEGRYHAFDDIHLMEQSGGKFGNNSGMGMFNANAHGGSASSILDAHQAFRNLEFTLSDYGGSSSNGSTTSPNGIGLDGEPVYECRHCGKKYRWKSTLRRHENVECGGKEPSHQCPYCPYKSKQRGNLGVHVRKHHTDLPQLPSKRRSKYSMNRENGMSGSMSDDSQGKLIIDFNGKGELETK
Protein: Target of Myb protein 1 (DdTom1) (Q54GH3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May contribute to the sorting of ubiquitinated proteins and transfer them for further sorting/trafficking processes to the endosomal multivesicular bodies (MVBs) pathway. Binds to phospholipids, such as phosphatidylinositol PtdIns(3)P and PtdIns(3,5)P2. These phospholipids are involved in the recruitment of the ESCRT machinery to endosomal membranes (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19054384}. Membrane {ECO:0000305|PubMed:19054384}; Peripheral membrane protein {ECO:0000305|PubMed:19054384}. Note=Localized to discrete punctae throughout the cytoplasm which are distinct from endocytic vacuoles expressing endosomal protein p80.
Interaction partners:
- Clathrin heavy chain
Sequence:
MVTELVDKATNELLIQTDWTTVLQISDILNRDPIHARGVVRQVTKKLKDRSRVILLALELADSLLQNCHCTHVYFAERTFQTELCRLIMNKKTKLNVKEKTLEIVESWGNAFQARHDVPGFYETYSFIKRSGYKFPPKPSDAPILNFNNSPAKRTVSTTILTNNSHSTTPPQANVPSFNNVSSVGSNNAGGGGSSSQPIKNQEISSIKGSTSVFNEMISFLNVEDEDPQENDLIKELFETCKQSQIRVKEMIESGSTNERDLNVLLKLNDEINNALNDHEACIKRRRAFVENGYKPVPPPQQQQQQQQQQQQQQQQQQQQQSHSNNHNGTTTTTTTNNNNKNPSYLTKHKELEEIDFFKAPDGISPYSVQQQLQPFQQQQFNSTYNPFAQPQPQQFQQQPQQQLQQQPQQQQGFNQRIQQPQQQADAFDLFVANRQQSNNNNNNNNINNTTSSFGANNPFANNSSNNNNTNGAIQPYIPNTAKSLPPVSQQLQQPMQNQFSPQPQKFVGSSITPSAPPPFKPNTTQSNPFNTSPPLNNMNNHNNNMMQQQQPQQQQQQQPQQQFNPMYNNNAMAPSYPNYNAIGADNQHNTNPYGMMNHQQQQQQQQQQQPMMNQMNNFSAPTYSQFTNYAQPNQQPYNNNYGGMNQSNMYPNNNMSGKSSLI
Protein: Syntaxin binding protein 1, putative (Q38FW1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- t-SNARE coiled-coil homology domain-containing protein
- Target SNARE, putative
- Exocyst complex component EXOC6/Sec15 N-terminal domain-containing protein
Sequence:
MSNHAKLSKQKPPESPGIRSCVQRYVFKNMLDAVPGKYKVIICDPPSAVVLNSFARMNDLMEHGVALVEDLKKKRQPLICLPAMYFFDPNDESVERIIDDWEEKDPYKEVHLFALGTTPDSYMQRLARARVAQRVTGFKDMMLNFLVPERLVFHFNMQNDLSRLMLPMQSPQCESFLSEAAARLTQVLHAMGGGIPVVRAQGRSQSCEVFSRLLLDELAKLAISVPNFENGVDDDGVDSSKPVLIILDRSFDTVTPLMHHRTYQCLLEDLMPLENDMYVQKFETRSGERSTRELSVDEEDPYWCQYRHRFFAECMEEFPAELKKLHNENPHLVNTREASPSITELSNVTRVLSTFQKDQGRLSVHIDICTKIFNLYREQCLDVVCEAEQDIAAGRKSFKTNFETVRHIIKDQAVPRDVRLRLLLLLSAATDTSEYSEAKKQTLIKQSELTEVAGAFSKLEQLTSRVGKLNPEGRNAKTSAEKDPFITQTYQIMEALAGNKLDTADYKYVTRSDESSGDATSNTAPSGGANTKKSLRVALGSSALWSDKGSAISDTLSSASEKPLAAIAALPPLPKAVHDLAGTGNVGGRSSKQRFVFFVLGGITFSEIRAAYEATKKLGCEFIIGGTSLLRPNEFVKVLSE
Protein: Histone H2A.Z (H2A/z) (P0C0S5)
Organism: Homo sapiens (Human)
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H2B type 2-E
- Helicase SRCAP
- Vacuolar protein sorting-associated protein 72 homolog
- Acidic leucine-rich nuclear phosphoprotein 32 family member E
- Histone H4
- E1A-binding protein p400
- Histone acetyltransferase KAT5
- RuvB-like 1
- Histone H2B type 1-J
- Histone H3.2
Sequence:
MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV
Protein: Aldo-keto reductase family 7 member A2 (H7C5H7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQLLEGAPLRGHCVGGEGPAGRIWRQRPQCDLGCPPVDVPPLTAAGCPRGRGHPGHVQPGAAGAELGSNRGRAPGAGCRGCL
Protein: Transmembrane phosphatase with tensin homology (Tyrosine-protein phosphatase TPTE isoform X1) (F1QG29)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Voltage-gated hydrogen channel 1
- Anoctamin
- DNA-dependent metalloprotease SPRTN
- Potassium voltage-gated channel, KQT-like subfamily, member 3
- Transient receptor potential cation channel, subfamily C, member 3
- Potassium voltage-gated channel subfamily A member 2
- Pleckstrin.
- Pleckstrin-2
Sequence:
MTSVHFNPGLDSKEVNGNSVKEEAEVQIDDGKEETKDPDTMYHQVRKKITPFVMSFGFRVFGLVLIILDIIMVIVDLSLSEKSRDVGGALETVSLVISFFFLIDVLLRVYVEGFKVYFSSKLNIVDACIVVITLVVTMIYAFSDFSGASLIPRVVTFLRSLRILILVRIFRLASQKRELEKVTRRMVSENKRRYQKDGFDLDLTYVTERVIAMSFPSSGKQALYRNPIREVVRFLDTKHMDHYKVFNLCSEKGYDPKFFHYRVERVMIDDHNVPSLDDMLRYTACVRDWMAADSRNVIAIHCKGGKGRTGTMVCTWLIDSDQFESAQESLDYFGERRTDKSMSSKFQGVETPSQSRYVGYYEIMKNQYNRQLPPRKSLKIKSIRIHSIAGVGKGNGSDLKLKIIVKHELVFQCVCAKQHNCTVFPDTGSNAVVISLQDGPIVTGDVKVMFESSAGLPKGYEDCPFYFWFNTSFVENYRLFLSREELDNPHKPKTWDIYKEDFGVTLSFTEP
Protein: Basic leucine-zipper 42 (Q9LW45)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQPQTDVFSLHNYLNSSILQSPYPSNFPISTPFPTNGQNPYLLYGFQSPTNNPQSMSLSSNNSTSDEAEEQQTNNNIINERKQRRMISNRESARRSRMRKQRHLDELWSQVMWLRIENHQLLDKLNNLSESHDKVLQENAQLKEETFELKQVISDMQIQSPFSCFRDDIIPIE
Protein: Phosphopantothenate--cysteine ligase (EC 6.3.2.51) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) (Q9HAB8)
Organism: Homo sapiens (Human)
Function: Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate.
Interaction partners:
- Phosphopantothenoylcysteine decarboxylase
- Bifunctional coenzyme A synthase
- Pantothenate kinase 1
- Pantothenate kinase 2, mitochondrial
- Pantothenate kinase 3
- 4'-phosphopantetheine phosphatase
- Kynurenine--oxoglutarate transaminase 3
- Kynurenine--oxoglutarate transaminase 1
- Cystathionine gamma-lyase
- Aspartate aminotransferase, cytoplasmic
Sequence:
MAEMDPVAEFPQPPGAARWAEVMARFAARLGAQGRRVVLVTSGGTKVPLEARPVRFLDNFSSGRRGATSAEAFLAAGYGVLFLYRARSAFPYAHRFPPQTWLSALRPSGPALSGLLSLEAEENALPGFAEALRSYQEAAAAGTFLAVEFTTLADYLHLLQAAAQALNPLGPSAMFYLAAAVSDFYVPVSEMPEHKIQSSGGPLQITMKMVPKLLSPLVKDWAPKAFIISFKLETDPAIVINRARKALEIYQHQVVVANILESRQSFVFIVTKDSETKLLLSEEEIEKGVEIEEKIVDNLQSRHTAFIGDRN
Protein: Uncharacterized oxidoreductase C24B10.20 (EC 1.-.-.-) (Q9P7I6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSAAGGIVYVIVGGNRGIGLSLVKELSNKEGVTVFASARGPGSASELKDWSKTHSNVHIIKLDVTSLRSAKDAAMQVEKVVKCIDVLWVNSGISKSFQPVLKTSDELWMSHYQTNVLGPIHVYQAFYHLLKEGKLKNIVFTSSMAACMGGVRPNTYSAYGQSKAALNYTMKEISFELEKDGFVVVSIHPGVVNTDMFVNAMQKLASKYPEMVESIKSNAISPEQSASSMLKIVDNLKTEDNGMFYNLDGTKLPF
Protein: Dachshund, isoform G (Q59DZ0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDSVTSEQSENNNNKAGAINNNINSGIERAAGNMNTTAMLMHHQQQQQAAAAAAAAAAQQQQQQHNGRDGSNSSRGANEDRPNGRSSHTGRGSSCSPASSPSRHPSAVSPVSSLNHSMMQQMQQQQQQQQQQQQQQQHHQLSPPPHGMPSGNGLPTGLPPRMPHGLPPHSLGLLNSLQMMHHASPLELMAAAHHHVPPRSYNSPPPISTSDPSANECKLVEYRGQKVAAFIISNETMLCLPQAFELFLKHLVGGLHTVYTKLKRLDIVPLVCNVEQVRILRGLGAIQPGVNRCKLLCCKDFDILYRDCTTARPGRPPKRGPVGLSLPPTHLSQHPQLKKHRLDNGDYAYENGHISDMKSPLLANGYNPPPINHMAFMQMNAHHPGAAALMSPGMPPHGLHARPESQMLKAAAQNAGMSAANMDALARSGIWENCRAAYEDIVKHLERLREERTDERQQAMGVGGAVVDRVGNVMVAEHKPRDLSSRNCSPTRQSPVLNLSKSGGNTDHGGSNCDAGSERSDCHSVAGSPARGGSRSLDEGSRSGVGGGVASHVGGGIIGVEDDEEEEENLSDENQSEVDERCLAKDDEDLSDTERDNLSTGSAAAAAAAAAAAAHQLHQHAASHHHQTVGLSHLGVVPPHQRGSPSSAEAAAAALQHQRALNYSQLAAAAAVANGAAVGGGAVANGPTGGGGALTPNEALLAANDAAALAGGLALGPLGIDAHAAVPASSTETLLRNIQSLLKVAADNARQQERQISYEKAELKMDVLREREVKDSLERQLVDERKLRVLYQKRFRRERKIRIRYQQQLGGGSGAVKGSPNANGSGGGGSGSACSESEACGGGGGDAKCNNNNNNNNNNNNSNSSSHGGDVETMKENDAGSEKSDKSLASNSSCDVTAGHSAGSVSGSISAGLNCPDSPTHFKREPSSDHEGSVERQPRSSAASLAAHDEDNTKRCGSRDRDERPPSGSAASVAAEGSLAAAAAAAAAAAAAAASNGKGPWSYPGIDLMATGAFWQNYSESLAQELEMERKSRAANAERDVKSPLSERPTAYYKNSVLFGSAN
Protein: Transcription initiation factor TFIID subunit 9B (Neuronal cell death-related gene in neuron 7) (DN-7) (Transcription initiation factor TFIID subunit 9-like) (Transcription-associated factor TAFII31L) (Q62880)
Organism: Rattus norvegicus (Rat)
Function: Essential for cell viability. TAF9 and TAF9L are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 13
- Transcriptional adapter 3
- SAGA-associated factor 29
- SPT3 homolog, SAGA and STAGA complex component
- Transcription initiation factor TFIID subunit 8
Sequence:
MEPSKMAPLKNAPRDALVMAQILKDMGITDYEPRVINQMLEFAFRYVTTILDDAKIYSSHAKKPTVDADDVRLAIQCRADQSFTSPPPRDFLLDIARQKNQTPLPLIKPYAGPRLPPDRYCLTAPNYRLKSLVKKGPNQGRLVPRLSVGAVSSRPTTPTVAPPQAVSVPNKVATPVSVTSQRFAVQIPTSQSTPAKPAPAATSVQNVLINPSMIGSKNILITTNMVSSQSTATDSNPLKRKHDDDDDDDDDDDDNDTM
Protein: NBPF family member NBPF1 (Neuroblastoma breakpoint family member 1) (Q3BBV0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16079250}.
Interaction partners:
- Hydrocephalus-inducing protein homolog
- SLIT-ROBO Rho GTPase-activating protein 2
- SLIT-ROBO Rho GTPase-activating protein 3
- G protein-regulated inducer of neurite outgrowth 2
- UDP-glucuronosyltransferase 2B17
- Puromycin-sensitive aminopeptidase
- D
- General transcription factor II-I
- NBPF family member NBPF3
Sequence:
MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHSPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDKPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKYKNEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASCSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMPKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYKSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALDVDNRFLTLMGTSLHLVFQMGVIFPQ
Protein: Cytochrome c oxidase assembly protein COX20, mitochondrial (Q9D7J4)
Organism: Mus musculus (Mouse)
Function: Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q5RI15}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAAAPEPHETEKKPFKLLGILDVENTPCARESILYGSLGSIVTGLGHFLVTSRIRRSCDVGVGGFILVTLGCWFHCRYNFAKQRIQERIAREGIKNKILYESTHLDPERKMKTNNSS
Protein: LD34931p (Q95RF1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFIKEEVMFEDSAALHSPQSPPSSKFRISNFDSDLVDHHVDLNHSLPPYGNLFEPHSIPDSIPVQLYPDDDDDFRLDHSSLGGLHNTTSSSTTDGDFIKKEWVYGTGASSYAMNGKFDDDSDALCDAANFIYN
Protein: Transcription factor MYB3R-2 (Myb-related protein 3R-2) (Plant c-MYB-like protein 2) (Protein PC-MYB2) (Q9SPN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (By similarity). Required for proper circadian rhythm.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- Transcription factor LRL2
- Homeobox-leucine zipper protein HDG9
- Homeobox-leucine zipper protein HDG3
- non-specific serine/threonine protein kinase
- Homeodomain-like superfamily protein
- Protein DETOXIFICATION 29
- E3 ubiquitin-protein ligase ORTHRUS-LIKE 1
- Probable E3 ubiquitin protein ligase DRIPH
Sequence:
MTESIDLNRSESESDNNTDDVTPIFAIDDSSKGRVSGPTRRSTKGGWTAEEDQILTNVVKKYQGRNWKRIAECLPGSEENRRNDVQCQHRWLKVLDPSLQKGAWKKEEDELLSELVKDYMENDRPPWSKISKELPGRIGKQCRERWHNHLNPTIIKSPWTREEELILVQAQRGNGNKWAEIAKLLPGRTENNIKNHWNCSVKKRLEQFPSNLFSGVVYGSKPSSGFEYNFFNQRNTMVESCITSQIKEAAKSPQRDFLDLTLGLNWRSISSSTSSLRGEESVSSSVDSVCARLNACLETPQNSNNDTVCVKEVREMKERLRMAARTFDTPSIISKTSSPASGLKRLRQKYDTPFPTDARSHMSSEEDHSVSASPSSKYRFVKRNTCSGSKPLERRLDFDFLLWDEHGRRNGIVNFSVRILPQKSDLKSGLVRPFWLR
Protein: Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (P49759)
Organism: Homo sapiens (Human)
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P22518}.
Interaction partners:
- Dual specificity protein kinase CLK4
- Serine/arginine-rich splicing factor 1
- Probable ATP-dependent RNA helicase DDX23
- Serine/arginine-rich splicing factor 2
- Cytochrome c
- Transformer-2 protein homolog alpha
- Dual specificity protein kinase CLK2
- NK-tumor recognition protein
- Serine/arginine-rich splicing factor 3
- SRSF protein kinase 2
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
Protein: Mannose-1-phosphate guanylyltransferase regulatory subunit alpha (GDP-mannose pyrophosphorylase A) (Q8SXU3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- Phosphomannomutase
- GDP-mannose 4,6 dehydratase
- Dolichol-phosphate mannosyltransferase subunit 1
- ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Dolichol-phosphate mannosyltransferase subunit 3
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 2 subunit 1
- Phosphoglucomutase 2a
Sequence:
MLKAVILIGGPQKGTRFRPLSLDTPKPLFPLAGRPLIAHHIEACAQLPDIREILIIGYYPQTQMEGFVGDMQALYSSSNINIRYLQEFTALGTAGGMYHFRDQIRAGNPRAFFVLNGDVCADFPLQELCDFHEKRPASALVTIMSTEATRQQSLHYGCLVFDRSSGAVSHYVEKPSSYVSTFINCGVYVCSMDIFTVLAQIFHSRGQEYSCQAFCNGNGNGNGREQGHIKWEQEVLTPLAGTDKLFAMPVPNWWSQLKTAGSAIYANRHYLGLYKKTHPERLANVGIKRGEGDGSLICTVHPDVYVHPSATVHHSAVLGPNVAIGPGVTIGPGVRIRESIVLEQAQILDHTLVLHSIVGRGSTIGAWARVEGTPSDPDPNKPFAKMENPPLFNNEGKLNPSITILGCFVQVPAEKILLNSIVLPHKELSRSFKNEIIL
Protein: Photoreceptor ankyrin repeat protein (Ankyrin repeat domain-containing protein 33) (Q7Z3H0)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8BXP5}. Nucleus {ECO:0000250|UniProtKB:Q8BXP5}.
Interaction partners:
Sequence:
MKVQPSVTCVASWGGIVHLEAFGDPVIVLRGAWAVPRVDCLIDTLRTPNASCMRKGTHLLVPCLEEEELALHRRRLDMSEALPCPGKETPTPGCRLGALYWACVHNDPTQLQAILDGGVSPEEATQVDSNGRTGLMVACYHGFQSVVALLSHCPFLDVNQQDKGGDTALMLAAQAGHVPLVSLLLNYYVGLDLERRDQRGLTALMKAAMRNRCADLTAVDPVRGKTALEWAVLTDSFDTVWRIRQLLRRPQVEQLSQHYKPEWPALSGLVAQAQAQAQVAPSLLERLQATLSLPFAPSPQEGGVLDHLVTATTSLASPFVTTACHTLCPDHPPSLGTRSKSVPELLGTAPPPPLVPQSPPGSPQRSPWVFVPYQSPQGILSKCLQWLQPRDSTSPRPQVPKILLSKASSSSHQCQPKPSPSGHQSLALPLWRYQELRIEKRKQEEEARMAQK
Protein: B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) (P11836)
Organism: Homo sapiens (Human)
Function: B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:22615937}; Multi-pass membrane protein {ECO:0000269|PubMed:22615937}. Cell membrane {ECO:0000269|PubMed:22615937}; Lipid-anchor {ECO:0000269|PubMed:22615937}. Note=Constitutively associated with membrane rafts. {ECO:0000269|PubMed:12920111}.
Interaction partners:
- B-lymphocyte antigen CD19
- Membrane-spanning 4-domains subfamily A member 3
- B-cell antigen receptor complex-associated protein alpha chain
- B-cell receptor CD22
- Immunoglobulin kappa variable 2D-29
- Immunoglobulin heavy variable 3-43D
- POU domain class 2-associating factor 1
- B-cell antigen receptor complex-associated protein beta chain
- B-cell scaffold protein with ankyrin repeats
- T-cell leukemia/lymphoma protein 1A
Sequence:
MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
Protein: Membrane-associated transporter protein (Slc45a2 protein) (Solute carrier family 45 member 2) (A8WG95)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MTLLTEDQPCRFSAPESPIASMEQYQVDSELKEDCLDNMEAAVFGAVEPPRRSRGRLIMHGSAMFGREFCYAVEAAFVTPVLLSVGLPRRLYSLVWLISPILGFILQPVIGSASDYCRSSWGRRRPYILLLGILMLVGMTLFLNGDAVTTAIISDRNLKRTWAIVVVMFGVVLFDFAADFIDGPIKAYLFDVCSHRDKERGLHYHALLTGLGGACGYLIGAMDWGHSALGSILGSEYQVIYFFSSLTWGIFLTTHLFSIPEKPLMKEPSSDSCPSASLLPEGPLQNGYGSVCKEPVSLSNVRERTFSVLSEANAVTPSAKQPNSEVQKRMTLKSLLSAMVSMPSHYRCLCMTHLLGWTAFLCNMLFFTDFMGQIVYKGNPYAEHNSTAYATYERGVEVGCWGLCINAVSSALYSYVQRLLLPYIGLKGLYFLGYFMFGLGTGLIGLFPNIVATLTLCCVFGVMSSTLYTIPFNLISEYHKAEEEQRKLGGDGVAPEGRGTGMDCAALTCMVQLAQVIVGAGLGALVNLAGSVIVVVLSASTVSLIGCLFIAIFM
Protein: DNA repair protein RAD2, putative (Q38DL8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein artemis
- DNA excision repair protein, putative
- Proliferating cell nuclear antigen
- DNA 5'-3' helicase
- Endo/exonuclease Mre11
- TFIIH basal transcription factor complex helicase/translocase XPB subunit
- DNA repair and transcription factor protein, putative
- DNA repair helicase/translocase XPB-R
- Crossover junction endonuclease MUS81
- DNA repair protein, putative
Sequence:
MGVHGLWRLLDTFGEVTQPADWKGKRVAIDASIWIAQFRSSCEPGESVEERILEGFFMRILKLLFYGIEPIFVFDGPSTMSKRAEQRRRAQHREALEQAMVTRHARRLIAAQMSAGLLDVHSLPRKYRSPGSGKKLQKPLRQSLPPTDLLHDVDEDVGESCVETGTILLQPKGRKKRTREVCLAPEVVSRSLTHSFLSEAEIFLEQRKTFEKFHENNRLAYTSTSIFMGPRRVAEEVSRALGGATRGEAESIQGSSAGNSSSSSVLVEGVGSAAIVVEEECGDSVCEILSSSSCSVIVVDNAIKTDPHAVDAFHHNVSFGKEEESTSDEVEVLSSGDYWSCADNDCDDLLSLAASDRTPDTQCNDSTHLWYPGTQLLGGLGSADDGGIVDESRDNCTETSCGLSEFNPFGGVVVPSGNLRKDEKEVLLNTSVITSSETLETTGIPLKVPSVSREHVREKQVVPFELLGIVELLDCCGIPYVLSPNEADAQCAFLNEQRVVDAVFTEDSDVIVHGAPVVLRGFFSKGRHVVAYRQSDLLACGVDKVVLVALALLLGCDYAEGVNGLSLLESLHVIAATWRQTTNSVEGGAEQVRDMLSSWCSAVRRRRIPWGEDVPLTRFYRNYVKWSTLQLADSFPESHVVDAYFNPTVNTDTRPFVCAAPDWTKLRLFASMHGILNKKYCGERLENAQRECQRRQPPSGDPADSAQRRLTDFFSPLPNRERVIFRKQPPKFSEALSYLRAARGDP
Protein: Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) (P24367)
Organism: Gallus gallus (Chicken)
Function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P23284}. Melanosome {ECO:0000250|UniProtKB:P23284}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:P23284}.
Interaction partners:
- Cartilage-associated protein
- Prolyl 3-hydroxylase 1
- Protein disulfide-isomerase
- Protein disulfide-isomerase A4
- Serpin H1
- Peptidylprolyl isomerase.
- RanBD1 domain-containing protein.
- Transmembrane protein 38B.
- TPR_REGION domain-containing protein.
- peptidylprolyl isomerase
Sequence:
MKALVAATALGPALLLLLPAASRADERKKGPKVTAKVFFDLRVGEEDAGRVVIGLFGKTVPKTVENFVALATGEKGFGFKGSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGDRFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMDVVRKVENTKTDSRDKPLKDVTIADCGTIEVEKPFAIAKE