wanglab/gogpt-training-data huggingface dataset:
Protein: Mediator of RNA polymerase II transcription subunit 24 (Mediator complex subunit 24) (dMED24) (dTRAP100) (Q9VSF2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 29
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 11
Sequence:
MKENNKILQLIYVAWRERWTDSQWGINIKKVLPRGVSGDVYNLADCLMQQALIGSTANPLVLNYLKHSLCAHLVSHAAVIRCIAKYDKLERVYCITALLEFLASIVDGVTCRIKSEEAVLPSSVVHLVYWLLQIFARTVQHYELYGEISAEQSYMLDQTCVVIDRLSQQQFLLSMLYVGCHEELEICGRIRDKYATIKGSLTNSNFTLNAPQVEQQLQQLAFIEAKHLEMQPLNPPSTLEKISCCVQPLLAVEVLLNPCKDTSYYVAELQMLQRLKKYSNTRLFYEIIRAGFLTLSNVADTSPDTMWGAFMFFKMPHIIKQLHALQRIPGEQPPPADYIPELVEALELLIEDNLLLDFMDTKCSCNMIEFLLNDWTKQQLVNDVHVKKFASQREAASQLLKKCDNGQQTPSNINFIKRAEVPLSGVLKTLCTNKVQDMVNVLCQVPVGNSFELILSVATVEGRLKTFVSRLIQCNENSKPVPGDLGKLCVIRSTLFDVSFLMLTSIVQTYGSDVVLSERGDSFFEKWVRECMVERNKLKNPRQILALCDDSIVDELLLSFSKPEASQLKPNNLSWQETCLNLPGVLHHVLIAWEQETLSSADVKSILDNIKRRLFSFSVCATSFLCAYMYSVKETELLKPLNMIQQFLAPLTSEELSSQENAKERLALSYQIIRKMQHDVHPAPSTKSRLISHSPLVEQFREVWRTVVDAGHLPVRAAQSLESLLLAGGAAWLSTQLVEQLLACKYTRDMSRTMDVVFAVMHLDIEKTTEALLQYVVAPLILRRQGEDINEPQSLVLARLCVYCIISCLESRKGNGTSALTAMKKRSRSHDDEELAANAAKVRKVIGDGSDNSSDFTDTTTGAGLAALLGSTSTSELRTTPLTLREPLQTSVQHIFAVFLQFVSGDELSPKAVFVYQFISLLVECGGERVAPVLRLLPNGLVQQLLKVLVTDDIKVGLISRLYDLRIQAGRLSAVSDLCLWRNMQMARHSIHL
Protein: Tubulin beta chain (Tubulin beta-5 chain) (P07437)
Organism: Homo sapiens (Human)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26637975}.
Interaction partners:
- Tubulin alpha-1B chain
- Tubulin alpha-1A chain
- Serine/threonine-protein kinase mTOR
- Tubulin alpha-4A chain
- Tubulin alpha-1C chain
- Tubulin beta-4B chain
- Tubulin alpha chain-like 3
- Tubulin alpha-8 chain
- Tubulin alpha-3E chain
- Tubulin alpha-3C chain
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA
Protein: Chitin synthase C (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase C) (Class-V chitin synthase C) (P78611)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- UDP-N-acetylglucosamine diphosphorylase
- Chitin synthase export chaperone
- alpha-1,3-glucan synthase
- alpha-1,3-glucan synthase
Sequence:
MSLPQRPGKTSPRREETSAFREPSRRRRRESDSLSNNDPTSPRHHRHHRSHSSRHQHDIDEERAEEGGIRRKRSLVKPERGRMDPSHPNYLYRQKTQNMPTYNPMTGNEPLIHEEGEAETNSTPSMDSKRKDALYGAHGNVNKPMERVPTRHRSKKRKGSRKISKREAAAEKRRRKAMEQVRPPSLWTTYCSVITFWAPDFVLKCFGMPQKAQRSAWREKIGLISIILMIAAFVGFLTFGFTATVCGTPPTRLKINEIGSGYMIFHGQAYDLTKSTHPAAAGIPDMTNVLYDLPHKYGGQDGSFFFQEVNGACKGLITRTENSDIPTNSNGDLAWYFPCHAFNQDGSSEPNTTVSYYNGWACHTSGSARKSFYSLKNSGDVYFTWEDTKNTSRKLAVYSGNVLDLNLLNWFDDTQVNYPTKFKDLRDNDDIRGVDLTYYFQTGEDKQIGKCLSQIIKVGSIDTDTVGCIASQVVLYVSLIFILSIVIVKFAFALLFQWFLAPRFAAQKTSMGAVDSKARNQQIEDWSNDIYRPGPRLADPVPGDRMSKRASFLPTTSRFSSPYTVSNGGKQKPQWVTMASQNSTTRLVPPASGTTPSIYRQSHNGLGNVSVDNSRLNPSASRTSLVQDSRYSTVIPDSEGIGSAGYVHELVVPQPPPDWQPYGFPLAHAMCLVTCYSEGEEGIRTTLDSIALTDYPNSHKSIVVICDGIIKGKGEEFSTPDIVLRMMRDPIIPPEEVEAFSYVAVATGSKRHNMAKVYAGFYDYGEHSIIPVEKQQRVPMMIIVKCGTPAEATAAKPGNRGKRDSQIILMSFLQKVMFDERMTELEYEMFNGLLHVTGIPPDFYEVVLMVDADTKVFPDSLTHMISAMVKDPEVMGLCGETKIANKTDSWVTMIQVFEYFVSHHQSKAFESVFGGVTCLPGCFSMYRIKAPKGGQNYWVPILANPDIVEHYSENVVDTLHKKNLLLLGEDRYLSTLMLRTFPKRKQIFVPQAVCKTVVPDKFMVLLSQRRRWINSTVHNLMELVLVRDLCGTFCFSMQFVIFVELVGTVVLPAAISFTIYVVVSSIIKQPVQIIPLVLLALILGLPGVLVVVTAHRLVYVLWMLVYLISLPIWNFVLPTYAYWKFDDFSWGDTRKTAGEKDKGHEDGEGEFDSSKITMKRWRDFEKDRRLRMQAGWQLPVGGHPPMPYEPYPEY
Protein: Hemochromatosis type 2 (Hemojuvelin BMP co-receptor) (Hemojuvelin precursor) (Hfe2 protein) (Q1JQE7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
- Transferrin receptor 2.
- Neogenin
- Neogenin 1b
- receptor protein serine/threonine kinase
- receptor protein serine/threonine kinase
- Serine/threonine-protein kinase receptor
- Bone morphogenetic protein 6.
- Receptor protein serine/threonine kinase
- Serine/threonine-protein kinase receptor
- Solute carrier family 40 member 1
Sequence:
MGMAASAGGGNHSHTTWRHIVIIVLMVLLFSAPSVCAQCRILRCNSDFVAATLESGVIGGGNKEGVNTGYCSALRSYALCTQRTARACRGDLAYHSAVQGIEDLLIQYRCPKAGPTAQPQPRPLPQAPLSGDGCFYEKGFIQREGRAPEYLHCGVFGDPHIRTFNEEFQTCAVQGAWPLIDNQYLYIQATSSPTRESSDTTILTEVTVIFQNWRECAEQQVYQAKLGNVPPAFADGSVTGGDRRGHQSLRIHSQDPGRHAEIWATHIGTMIIVRQVGQSLSLSVRSPRAIVESYTPEQDLQLCVWGCPISQRLEMLHAHPFDPAYTHCSSLFPGRDVYFQACLFDVQVTGDVNSSASAVAALEDARAMISDPASVHLVTGGTGNNSPSLLVVLGFSFLTETLRHSFLGSA
Protein: Acetyl-coenzyme A synthetase (EC 6.2.1.1) (D3ZZN3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Citrate synthase, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- NAD-dependent protein deacetylase
- Peroxisomal acyl-coenzyme A oxidase 1
- Aldehyde dehydrogenase X, mitochondrial
- Acetyl-coenzyme A thioesterase
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase family 3 member A2
- Aldehyde dehydrogenase family 3 member B1
- Ethylmalonyl-CoA decarboxylase
Sequence:
MAARSLGSGVGRLLRGLHGHSGQSGWLLSLSRWTTTRFLGSVPAAAQLGSYPALSAQAAQEPAAFWGPLARDTLVWDTPYHTVWDCDFRTGKIGWFLGGQLNVSVNCLDQHVQKSPDTIALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAIHTVVFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKNCPTVQHVLVAHRTDTKVPMGNLDIPLEQEMANEAPVCTPESMNSEDMLFMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYHPGDVFGCVADIGWITGHSYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAVRLLLKFGDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDGRCTLVDTWWQTETGGICIAPRPSEDGAEILPGMAMRPFFGIVPALMDEKGNVVEGGDVSGALCISQAWPGMARTIYGDHQRFVDAYFRTYPGYYFTGDGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIGYPHDIKGEAAFAFIVLKDDVRDANVVVNELKLAVATKIAKYAVPDQILVVKRLPKTRSGKVMRRLLRKIITSRGQDLGDTTTLEDPSVITEIMSAFREYEEQRAATN
Protein: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (OMPDCase) (OMPdecase) (P0CB75)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Interaction partners:
Sequence:
MREHRPIIALDFPSFEAVKEFLALFPAEESLYLKVGMELYYAAGPEIVSYLKGLGHSVFLDLKLHDIPNTVKSAMKILSQLGVDMTNVHAAGGVEMMKAAREGLGSQAKLIAVTQLTSTSEAQMQEFQNIQTSLQESVIHYAKKTAEAGLDGVVCSAQEVQVIKQATNPDFICLTPGIRPAGVAVGDQKRVMTPADAYQIGSDYIVVGRPITQAEDPVAAYHAIKDEWTQDWN
Protein: Small ribosomal subunit protein cS22 (30S ribosomal protein 2, chloroplastic) (Chloroplastic small ribosomal subunit protein cS22) (Plastid-specific 30S ribosomal protein 2, chloroplastic) (PSRP-2) (Q8VYM4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus. May have a role in the recruitment of stored chloroplast mRNAs for active protein synthesis (By similarity). Bind single strand DNA (ssDNA) and RNA in vitro. Exhibits RNA chaperone activity. Regulates negatively resistance responses to abiotic stresses during seed germination (e.g. salt, dehydration, and low temperature) and seedling growth (e.g. salt).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:21923745, ECO:0000269|PubMed:24220572}.
Interaction partners:
- Large ribosomal subunit protein cL37
- Large ribosomal subunit protein cL38
- Small ribosomal subunit protein bTHXc
- Ribosome-recycling factor, chloroplastic
- Peptidyl-prolyl cis-trans isomerase FKBP19, chloroplastic
- Ribosome-recycling factor, chloroplastic
Sequence:
MATFLTNVVSIKPTIFSFQSESFTPLHTRVNVFSSKPFPSLAGTFSRSSRTRFIPYAVTETEEKPAALDPSSEAARRVYIGNIPRTVTNEQLTKLVEEHGAVEKVQVMYDKYSGRSRRFGFATMKSVEDANAVVEKLNGNTVEGREIKVNITEKPIASSPDLSVLQSEDSAFVDSPYKVYVGNLAKTVTKEMLENLFSEKGKVVSAKVSRVPGTSKSTGFGFVTFSSEEDVEAAIVALNNSLLEGQKIRVNKA
Protein: Cardioactive peptide (Cardioacceleratory peptide 2a) (Crustacean cardioactive peptide) (CCAP) (Q9VCW0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cardioregulatory neurohormone that increases heart beat rate during adult wing inflation; has no effect on beat amplitude. The effect of CCAP is both ino- and chronotropic (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q8WRC7}.
Interaction partners:
- Ecdysis triggering hormone
- Bursicon
- Cardioacceleratory peptide receptor
- Eclosion hormone
- Adipokinetic hormone
- Partner of bursicon
- Leucokinin
- Short neuropeptide F
- Beta glycoprotein hormone related polypeptide
- GEO08248p1
Sequence:
MRTSMRISLRLLALLACAICSQASLERENNEGTNMANHKLSGVIQWKYEKRPFCNAFTGCGRKRTYPSYPPFSLFKRNEVEEKPYNNEYLSEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKMLQNEKEMQQLEERESK
Protein: Uncharacterized methyltransferase AN0656 (EC 2.1.1.-) (Q5BFM4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Involved in osmoadaptation.
Interaction partners:
Sequence:
MTNQTIQEALGHGQGNDLGNSDGHRIEYVETIEAYNKWAEVYDTDGNFLQALDTFEMKDLLPRFLCLVQTQTNGKSNMTPGEQVLKLVDLGCGTGRNTLQLAKSAPKEAQIIGLDASPGMLEVAEGNLKAQGVMGTVDERRVVLGVYDLLSPRPESLPVSLRGEARASGAISTLVLEHIPLDKFFEGAARLIRPGGYLLVTNMHAEMGAISQAGFVDVTSGKKIRPTSYAHEVGNVIAAAERAGFEIVPLNGAEKVRERRVNEEMVALLGSRARKWVNVVVWFGLS
Protein: General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) (P19447)
Organism: Homo sapiens (Human)
Function: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular location: Nucleus.
Interaction partners:
- General transcription factor IIH subunit 3
- General transcription factor IIH subunit 5
- Cyclin-dependent kinase 7
- DNA repair protein complementing XP-A cells
- General transcription factor IIE subunit 1
- Cyclin-H
- General transcription factor IIH subunit 4
- Transcription initiation factor IIE subunit beta
- CDK-activating kinase assembly factor MAT1
- General transcription and DNA repair factor IIH helicase subunit XPD
Sequence:
MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQGKSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKRFRK
Protein: DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II 13.2 kDa polypeptide) (DNA-directed RNA polymerase II subunit 9) (O74635)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). Involved in the regulation of transcription elongation.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P32529}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit rpb4
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit rpb7
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit rpb1
- Transcription elongation factor S-II
Sequence:
MSNFQYCIECNNMLYPREDKVDRVLRLACRNCDYSEIAATSKVYRHELQSSNVENTTVSHDASTDPTLPRSDKECPRCHQHEAVFYQTHSRRGDTMMTLIYVCVHCGFAFEEQ
Protein: Frizzled 8a protein (Frizzled class receptor 8a) (Frizzled homolog 8a) (Frizzled-8a precursor) (Q9YI00)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Protein Wnt
- Protein Wnt
- Protein Wnt-8a
- Tyrosine-protein kinase RYK
- Glypican 4
- Protein Wnt-8b
- E3 ubiquitin-protein ligase znrf3
- Protein Wnt
- Protein Wnt-4a
- Protein Wnt-11
Sequence:
MECYLLGIYLFLALALLPRSSGTTAKEITCQEIAVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGAPDTLCMDYNRTDSTTVSPVLSKPTNYPSKAINPHKKKSGRPGVGPNKNKPCEPGCQCRAPMVPVNSDRHPLYNRVKTGQIPNCAMPCHNPYFTQDERTFTAFWIGLWSVLCFISTFATVATFLIDMERFKYPERPIIFLSACYMFVSIGYIVRLIAGHEKVACNREYDVEHIHYETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLIPSMKSIAVLALSSVDGDPVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATIIVACYFYEQHNRQSWEITHNCSCLLEQEIKRPDYAVFMLKYFMCLLVGITSGVWTWSGKTLESWRSFCTRCCWGSKGSGGSMYSDVSTGLTWRSGTASSVSCPKQMPLSQV
Protein: Zinc finger protein 983 (E9PUT0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDNFPVNMSQCLLTFGDVSVDFSQEEWECLDSAQRALYIDVMLENYSNLVSVENYSTCDTVHQHVKTQKESCQRNNLGEMLRDPSHDALYKRGDTTETSNNHRCCKDRDSSVDSSNQCRHRSIHTGEEPCISEDCEKSLNVCSSIIQDKRLYTANKKHREDEYDNYFNCTYNLMQQKVYLEEKSHECGKCGKCFSTSSRLIKHQRIHTGNKPFKCDICDKSYNRCANLKIHQRVHTGEKPYKCKECGKSFRQTSVLKSHQKMHTGEKPYKCKQCDKSFAHSSSFRTHQKIHTSEEHCSCSECGREFHQLSHLRKHYRLHTGEKPYKCNECDASFTHYASLKWHQKTHTPEIHYECKECGKSFLELSHLKRHSRTHTGEKPYKCEVCDKSFSVNSALKIHSKIHTGEKPYKCMECDKSFTHNSNLRAHQRVHTGEKPYKCTECDKSFTRCSYLRAHQKIHT
Protein: Transcription initiation protein SPT3 homolog (Q8BWQ2)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNNAAASPMSTTTSSSGRNAGKTISFAAELQSMMFSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIIKGIDEDDLLEEKLSGSSGTNKRQKIAQDLINSIDQTGELLAMFEDNELDDVKQERMERAERQTHTMDSAQYAEFCESRQLSFSKKASKFRDWLDCSSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVSKAGDPFSHAISATFIQYHNSAEGSSCLKSSPDSPENTPPPTPTAPSSGSQHSGRAASGSLGNGNTGQDTAKTKQRKRKKSTAACGVEAHSDAIQPCHIREAIRRYGHKIGPLSPFTSAYRRSGMAFLAC
Protein: Ubiquitin-conjugating enzyme spm2 (Ubiquitin-conjugating enzyme variant MMS2 homolog) (UEV MMS2) (O74983)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in the DNA error-free postreplication repair (PRR) pathway. Lacks catalytic activity by itself. The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 13
- Polyubiquitin
- DNA polymerase zeta catalytic subunit
- DNA repair protein rad8
- Protein sip5
- DNA repair protein rhp51
- DNA repair protein rev1
- ATP-dependent DNA helicase srs2
- Ubiquitin-conjugating enzyme E2 1
- Ubiquitin-conjugating enzyme E2 2
Sequence:
MAKVPRNFKLLEELEKGEKGLGESSCSYGLTNADDITLSDWNATILGPAHSVHENRIYSLKIHCDANYPDAPPIVTFVSRINLPGVDGETGKVNPHKIDCLRHWKREYSMETVLLDLKKEMASSSNRKLPQPPEGSTFF
Protein: Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (A5I640)
Organism: Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Function: Acts as a chaperone.
Interaction partners:
Sequence:
MAKIIGIDLGTTNSCVSVMEGGEPVVIPNAEGSRTTPSVVSFQANGERLIGQVAKRQAITNPEKTIISIKRYMGTDHKVNIDSTEYTPQQISAMVLQKLKADAEAYLGEKVTQAVITVPAYFNDSQRQATKDAGKIAGLEVLRIINEPTAASLAYGLDKMDTNEKILVYDLGGGTFDVSILELGDGVFEVKATNGDTKLGGDDFDQKLIDYIAETFKAENGIDLRNDKMAIQRLKEAAEKAKIELSSATQTNINLPFITADATGPKHIDMNLTRAKFNELTHDLVQRTLEPIKKSLEGSGYAMSDIDKIIMVGGSTRIPAVQDAVKDFTGKELSKGVNPDEVVAMGAAIQAGVLTGEVKDVLLLDVTPLTLGIETFGGVSTTLIEKNTTIPTRKSQVFSTAADGQTSVEIHVVQGERSMAADNKTLGRFTLSGIAPAPRGIPQIEVTFDIDANGIVNVSAKDKGTGKEANITITASTNLTDDEIEKAVNEAKKFEAEDKKRKESIEIKNNADQIVYQTEKTLTDLGDKVSAEDKAQIEEKVKAVKDVKDGEDLEAIKKATEDLTQTFYGISSKIYQQANPEGAQGAGFDPNNMGGANAGNASAGNDKKDDNVVDADFKVEDDK
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4) (Q62711)
Organism: Rattus norvegicus (Rat)
Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
Subcellular location: Endomembrane system; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
Interaction partners:
- Protein kinase C beta type
- Inositol polyphosphate multikinase
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Inositol polyphosphate-5-phosphatase A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2
- Protein kinase C gamma type
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphoinositide phospholipase C
Sequence:
MASQIQKLLTTNQDLLLMQKGTMMRKVRTKSWKKLRYFRLQDDGMTVWHGRHLESISKPTFSISDVERIRKGQDSELLRYLVEEFPLEQGFTIVFNGRRPNLDLVANSVEEAQTWMRGLQLLVDLVARMNYQEQLDQMLREWFQQADRNQDSRMSFREAQRLLLLMNVEMDEEYAFSLFQEADVSQSNTLDSEEFVQFYKALTKRTEIEELFENFSSDKQKLTLLEFVDFLREEQKESDHSSDLALKLIDRYEPSENGRLLRVLSKDGFLSYLCSADGNIFNPDCLPIYQDMTQPLSHYYINSSHNTYLLGDQFCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGRTLTSRILFKDVLATLAQYAFQSSDYPLILSLDNHCTWEQQKTMAHHLIAILGEQLLSTTLEEQLIDIMPSPEQLRGKILVKGKKLRTIEVVESDKEEEELEKDEGSDLDPASAELDMQSQPESQEQASGNKSKNKKKFLLQSSTTILCPDLSALVVYLRTAPFCSFTHSKENYHIYDISSFSESKAKNLIREAGNEFVQHNARQLCRVYPSGLRTDSSNYNPQEHWNVGCQMVAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSFNPMKPVSLYKAQILVVQVISGQRLPKVDKTKETTVVDPLVRVELYGVPEDTKQQETSYVENNGINPYWGETFYFQIQVPELAMLRFVVKDYSRTSRNNFIGQYTLPWTCMKHGYRHVSLLSKDGTSLHPASIFVYTCMQEDLDMDEP
Protein: E3 ubiquitin/ISG15 ligase TRIM25 isoform X2 (Tripartite motif-containing 25) (A0A2R8QTG3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAEQMSLLGLEDELTCSICLCLFDNPVSLICGHSFCANCLEETWKDKISSLFCPHCRMAFSSKPELKKNTVLGAVLDAYRVKAGISEPVKNPVEEKKKDPDAIKCDSCMEAKAVKTCLTCMASYCEDHVRPHRENAIFRAHQLCDPLPDLMERLCSDHGKLMEFYCIQHQSCICSTCLQYIHKGCEFITADERRFKQKTDLTDKLNMIEGKMDKNEQVITQMKEQQNKLKDLAATRKRILEAEYSQIREMIDRDEKEAMLAIDKEQERGQSKLVSLMKKFNENIEKMERTKCEINSLLDQSQSLSFLKASIDLPSVINFEPYNPRMNLDSKEVIAYHSSAVALKEWITKLMEQSTENRISVLKPGYQSPGILGGTPAFLPNPRDMSYMRPPCSSKPKVLPSKKKNPDRRDTKEKPNRSKNPTQGINPVFSKSMDNLNELRPKTVDIIDINQPASSSAVQNVKRSDLLKYGTILHFDVRTAHKRISLSENNTKATVSDDPANYPEIPHRFSVCSQVLCTKGFSQGRHYWEIKMSSNNFCGLGLAYGKIDRKGPSSRLGRNAESWCVEWFNVKLSAWHNSFETVLENPNPSRVGILLDCDQGSATFYNVQDRAYPFHTFVFPFTEAVYPAFWIFSNGSSVSLCKLNN
Protein: Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X) (P43235)
Organism: Homo sapiens (Human)
Function: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
Subcellular location: Lysosome {ECO:0000269|PubMed:11082042}. Secreted {ECO:0000269|PubMed:11082042}. Apical cell membrane {ECO:0000269|PubMed:11082042}; Peripheral membrane protein {ECO:0000269|PubMed:11082042}; Extracellular side {ECO:0000269|PubMed:11082042}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. {ECO:0000269|PubMed:11082042}.
Interaction partners:
- Apoptosis regulator Bcl-2
- Tartrate-resistant acid phosphatase type 5
- Serpin B13
- Bcl-2-like protein 1
- BH3-interacting domain death agonist
- Procathepsin L
- Nuclear factor of activated T-cells, cytoplasmic 1
- Tumor necrosis factor ligand superfamily member 11
- Matrix metalloproteinase-9
- Dendritic cell-specific transmembrane protein
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM