wanglab/gogpt-training-data huggingface dataset:
Protein: Translin-associated factor X-interacting protein 1 (Trax-interacting protein 1) (Q2TAA8)
Organism: Homo sapiens (Human)
Function: Possible role in spermatogenesis.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q99P25}.
Interaction partners:
- Translin-associated protein X
Sequence:
MGGHLSPWPTYTSGQTILQNRKPCSDDYRKRVGSCQQHPFRTAKPQYLEELENYLRKELLLLDLGTDSTQELRLQPYREIFEFFIEDFKTYKPLLSSIKNAYEGMLAHQREKIRALEPLKAKLVTVNEDCNERILAMRAEEKYEISLLKKEKMNLLKLIDKKNEEKISLQSEVTKLRKNLAEEYLHYLSERDACKILIADLNELRYQREDMSLAQSPGIWGEDPVKLTLALKMTRQDLTRTQMELNNMKANFGDVVPRRDFEMQEKTNKDLQEQLDTLRASYEEVRKEHEILMQLHMSTLKERDQFFSELQEIQRTSTPRPDWTKCKDVVAGGPERWQMLAEGKNSDQLVDVLLEEIGSGLLREKDFFPGLGYGEAIPAFLRFDGLVENKKPSKKDVVNLLKDAWKERLAEEQKETFPDFFFNFLEHRFGPSDAMAWAYTIFENIKIFHSNEVMSQFYAVLMGKRSENVYVTQKETVAQLLKEMTNADSQNEGLLTMEQFNTVLKSTFPLKTEEQIQELMEAGGWHPSSSNADLLNYRSLFMEDEEGQSEPFVQKLWEQYMDEKDEYLQQLKQELGIELHEEVTLPKLRGGLMTIDPSLDKQTVNTYMSQAFQLPESEMPEEGDEKEEAVVEILQTALERLQVIDIRRVGPREPEPAS
Protein: Ubiquitin-like protein 4A (B7NZQ9)
Organism: Oryctolagus cuniculus (Rabbit)
Function: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P11441}. Nucleus {ECO:0000250|UniProtKB:P11441}.
Interaction partners:
- Sodium/bile acid cotransporter 7
- Retrotransposon Gag like 5
- Ubiquitin-like domain-containing protein
Sequence:
MQLTVKALQGRECNLQVPEDEQVSTLKQLVSEKLNVPVRQQRLLFKGKALADGKRLSDYSIGPNSKLNLVVKPLEKVLLAEGTARRLADSPPPPVWHLISKVLARHFSAADASRVLEQLQRDYERSLSRLTLDDIERLASRFLHPEGTEAMEKGLSK
Protein: Protein SWOLLEN 1 (Protein G2484-1) (AtG2484-1) (F4JP43)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000269|PubMed:37676567}.
Interaction partners:
- Protein DOWNSTREAM OF FLC
- Uncharacterized protein
- Asparagine--tRNA ligase, cytoplasmic 2
- Protein RECOGNITION OF PERONOSPORA PARASITICA 7
- Protein CTR9 homolog
- Protein CDC73 homolog
- Protein PAF1 homolog
- Asparagine--tRNA ligase, chloroplastic/mitochondrial
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- At2g30720
Sequence:
MDYDDSDFQNQNLHLAGEANNKFPPVLQPYALPKFDFDDTLNTHLRFDSLGESEAFLGIEGNEDNNWIEDFSRGSSGIVFSSGATESCAISRHNNVWSEATSSESVAMLLNSVGQDEVIVREDTIKKSDTSHELGCTMETVEPGQTSHERSLSKEETVNLQPNPSVDDTPGESSVVKTDDGQEQVLVKDDSPTAVEEASVEEKNSILTSNTATVEAIDTTDLGKIGTETTDNLLDQTEEKANVESRMEDDCSDGNVQTIITCSGELNNQSTLLPETSNDENVISDHIQSSYNRNDLTADARSILVEGHSDSHIDSASEVEKVEAENIGKTAKPDLKEIELSDVTVLERGDQAPSTLEVGGQDVSGTECQDLLVSTVHTSVAVEASLELAGELTTITNSVSIEKPELLSHQHMEVITSEHESTFQIETETYPQIHVFETSESVYISTMDSMVEAREGGVSKKSDNEGSARTSNLEQSMELPVNANDRDQDVKNSQILSESVVSGSVGYVSGGSTSELAESESQSDSIPTDKSETMIDSSLNLEELQPLSQDGAPAVSLTSSIDLHMVKTSSDDSDQGSYSETKKVYGEPENGQTVPPVDASCSGSQMDQEARKRAEGTKQSTYSVEGCPRSEGSKDAVDADGVGQVLQQQSEELIFEENVVTEAVKAPETLSVLDKDNKNEMPITSSLPILGSEAGKDGQEEDNTAASGGIMAAGTPVTHPKGDAIVLGDSRASTCSESSVKSYVTAIEDAATNLKTPLDSFPTVKTSELQFNNTETNSVKKPEDQNISGFMSAGSPVLNRNETSSSEMNLTPDQLKAGKISKAVIFSQATLVSPIVVGSPSTSSLDKTAAKSSKAKSERKPRRTSKSVGKETSRKGTSVKGATPIEQFQSGGKTNAVNQSLASHIQITQSTEKQRSLQSPALKAFGSLSTPTASLPDLNSSALSSILRRPFTDLQQVQLRAQIFVYGALIQGTAPDEAYMISAFGGADGGKGSWEKSWRTCVVRAQKSLVATPETPLQSRPGKTETPSAGHTNSKESSGTNPMIPLSSPLWSLSTSVDTLQSSSVQRGSAATHQPLLSASHAHQTPPTQNIVGHNTPWMSPLPFRNAWLASQQTSGFDVGSRFPVYPITDPVKLTPMKESSMTLSGAKHVQSGTSSNVSKVTPTLEPTSTVVAPAQHSTRVKSRKRKKMPVSVESGPNILNSLKQTELAASPLVPFTPTPANLGYNAGTLPSVVSMTAVPMDLVSTFPGKKIKSSFPSPIFGGNLVREVKQRSVLSEDTIEKLKEAKMHAEDASALATAAVSHSEYVWKQIEQQSHAGLQPETQDRLASAAVAIAAAAAVAKAAAAAANVAANAALQAKLMAEEASLPNASDQGLPKSYDSILPGQGTPASILKGEGAVVNSSSVLIAAREASKKRVEAATAATKRAENMDSIVKAAELASEAVSQAGILVSMGHPPLLNKLVEAGPSNYWRQAQESQEVQPCKTVVLEKETVSTSEGTFAGPKIVQTEFGGSVNTADGVSGPVPATGKLKGQEGDKYADLAKNNDVVFEPEVGSKFSIDAQQTIKATKNEDIKEGSNVEVFKEEPGLRTAWYSANVLSLEDDKAYVLFSDLSVEQGTDKLKEWVALKGEGDQAPKIRPARSVTALPYEGTRKRRRAALGDHIWKIGDRVDSWVHDSWLEGVITEKNKKDENTVTVHFPAEEETLTIKAWNLRPSLVWKDGKWIECSSSGETISSSHEGDTPKEKRPRLGTPALVAEVKDTSMKIVDDPDLGKPPQTGVLNLGVSENTFNIGKSTREENKPDPLRMKRTGLQKQGSKVIFGVPKPGKKRKFMDVSKHYVSEASTKTQERKEPVKPVRSIVPQNSGIGSWKMPSKTISIEKQTTISRPKTFKPAPKPKEKPGATARIIPRKDSRNTTASDMESDESAENRGPGSGVSFKGTVEEQTTSSSHDTGSKNSSSLSTNKGRVAPTAGRLAKIEEDKALAENSSKTSEGMEPRRSIRRIQPTSRLLEGLQTSMMTSKIPSVSHSKSHLSQSKK
Protein: Mortality factor 4 like 1 (H0YNE0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XLLYEAKCVKVAIKDKQVKYFIHYSGWNKNAVRPRRSEKSLKTHEDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDY
Protein: Division inhibition protein DicB (P09557)
Organism: Escherichia coli (strain K12)
Function: Involved in cell division inhibition; this function can be repressed by DicA and DicC proteins as well as antitoxin CbeA (yeeU).
Interaction partners:
- Septum site-determining protein MinC
- Uncharacterized protein YdfD
- Repressor protein of division inhibition gene dicB
- HTH-type transcriptional regulator DicA
- Cell division protein ZipA
- Killing protein KilR
- Uncharacterized protein YdfA
- Cell division protein FtsZ
Sequence:
MKTLLPNVNTSEGCFEIGVTISNPVFTEDAINKRKQERELLNKICIVSMLARLRLMPKGCAQ
Protein: Inner centromere protein, ARK-binding region protein (Q9FM57)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Small ribosomal subunit protein mS75
- 110 kDa U5 small nuclear ribonucleoprotein component CLO
- Splicing factor SF3a60 homolog
- Probable helicase MAGATAMA 3
- Eukaryotic aspartyl protease family protein
- Chaperone protein dnaJ GFA2, mitochondrial
- Probable aspartic protease At2g35615
- DnaJ protein P58IPK homolog
- Cysteine--tRNA ligase, chloroplastic/mitochondrial
- GTP-binding protein-like protein
Sequence:
MIRDSENKTTTAKVLKDREKRHRMKKSRSSAMFSVKENPRGKTANVKIENLFVQIFERKRRIVEQVQQQVDLYDQHLASKCLLAGVSPPSWLWSPSLPSQTSELNKEEIISELLFPSSRPSIVCPSSRPFSYQRPVRFLADNVVRQDLTSVVNNPLEEQLLEEEPQHNLSHNLVRQVSNHSHEQDVNIASPRDVHEKERLPESVSIDCRENQSCSSPEHSKNQRVETNLDATSPGCSQGEKVPKCVSTTGCKRKSSSLGYCQEEIEPDTCIDPGLSLAKMQRSRSRQKALELRSSAKASKSRSNSRNELKPSPGGDIGFGIASLRSDSVSEIKLFKHDENDEECREEVENSNSQGKRGDQCIKISVPTESFTLHHEVDSVSISSSGDAYASIVPECLLESGHVNDIDILQSIETIDEASGKVDEQVDDPKSRSCYETAYLDGSTRSKSSIQDNSKRKHQKSSNSFSGNFLLTNSNPSHWADHEVELPQAITTTSEVSMVTDAGTSIFQSEIIARSRSNARENRSKTEHSGSVESSSINLEPRDSIPVLQGSHVKDSLNPSSVDAEGLVVENITSSDQSKETGECVDTNRCSSAERVSQTGISPDETTFAGAIQDSISQIELLSFVESSSIELQSRHSVKQSDDESVLLKPVTVNGEALLVEEDNNGESTEISGISKSRSLSQTDITVVLPVVVESILNESGTPEKLIDHSKRCDISCGSKEVQPLGSLTEVGSNQSHGIISRARSSLIEEESANDYKALSDGSNHKSADKQLEVREGNSLLRTPDRPVFVDNFDEVPENSREKSSMEKVPTPAPTARVFDVPSLTDSGVNLSANNEMNDIEDHNGLNIEMVAEMESYASHPGLKVGENEPTESNTFTGHIDALTKRPQHETSSEKAVPPIKRDVTCTEADECHDLESPIQEFFCSSSPMGGSMRQNKRRRILEKPTRRELSSSPGGDILESDYVREAVHHREEAACHNVDNYDVELQKLIGSASSHHYSVELQKMIGSASSAELRFEEGDILESDYVREAVHHREEAACHNVDNYDVELQKLIGSASSHHYSVELQKMIGSASSAELRFEESYLLKEAGLMSPASLSYRTEQLSVQRSQIAPDHRVGSENINFFPYAGETSHGLASCIVRDSDSSPCLTPLGLISSDDGSPPVLEGFIIQTDDENQSGSKNQLNHDSFQLPRTTAESAAMIEQICKSACMNTPSLHLAKTFKFDEKLDLDQSVSTELFDGMFFSQNLEGSSVFDNLGINHDYTGRSYTDSLPGTGSSAEARNPCMSPTEKLWYRSLQKSSSSEKRSTQTPDLPCISEENENIEEEAENLCTNTPKSMRSEKRGSSIPELPCIAEENENIDEISDAVNEASGSERENVSAERKPLGDVNEDPMKLLPSVSEAKIPADRQSLDSVSTAFSFSAKCNSVKSKVGKLSNRRFTGKGKENQGGAGAKRNVKPPSSRFSKPKLSCNSSLTTVGPRLQEKEPRHNNIVSNITSFVPLVQQQKPAPALITGKRDVKVKALEAAEASKRIAEQKENDRKLKKEAMKLERAKQEQENLKKQEIEKKKKEEDRKKKEAEMAWKQEMEKKKKEEERKRKEFEMADRKRQREEEDKRLKEAKKRQRIADFQRQQREADEKLQAEKELKRQAMDARIKAQKELKEDQNNAEKTRQANSRIPAVRSKSNSSDDTNASRSSRENDFKVISNPGNMSEEANMGIEEMEESYNISPYKCSDDEDEEEDDNDDMSNKKFAPTWASKSNVRLAVISQQNIDPDVTFPAKSACDISNGSVDFPSGKSQVLKARDLFFFNITKFSLLFNVDFVKITFG
Protein: EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) (Q3UP38)
Organism: Mus musculus (Mouse)
Function: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity).
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q9BSW2}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q9BSW2}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q9BSW2}. Cell membrane {ECO:0000250|UniProtKB:Q9BSW2}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9BSW2}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9BSW2}. Vesicle {ECO:0000250|UniProtKB:Q9BSW2}. Note=T-cell activation-induced elevation of intracellular of Ca(2+) stimulates its transport toward the microtubule organizing center (MTOC). Histamine stimulation induces a trafficking to the MTOC in a GTP-binding-dependent but Ca(2+)-binding-independent manner. Localizes to Golgi membrane in resting T-cells and upon its interaction with VAV1, is translocated from the Golgi membrane to the immunological synapse via subsynaptic vesicles. Its localization in the Golgi membrane requires isoprenylation and GTP-binding. {ECO:0000250|UniProtKB:Q9BSW2}.
Interaction partners:
- Ras-related protein Rab-44
- Stromal interaction molecule 1
- Ras-related protein Rab-15
- Cytoplasmic dynein 1 light intermediate chain 1
- Store-operated calcium entry-associated regulatory factor
Sequence:
MATPSGREDSSSQTPGHGKQGSGACVEQLDHPEKLEVEMPDQSAMWKKAQEFFQTCDSEGKGFIARTDMQRLHQELPLSLEELEDVFDALDADGNGFLTPEEFTTGFSHFFFSQNIQGEEEADQQVAQLQEEKVYQSRGEEDVGDMDHDEEAQFQMLMDRLGAQKVLEDESDVRQLWLQLRKDEPHLLSNFEDLLTTIFAQLQEAHEQKNELECALRKKIAAYDEEIQHLYEEMEQQIKSEREQFLLKDTERFQARSRELEKKLSAKEQELERLNQKQRKLEGQCAALHNDKHETKAENSKLRLTNQELARELERTSHQLQEAQQQLESLQREACELQQEKEMEVYRVTESLQREKSGLLKQLDFLRERNKHLRDERDITFQKDKAAKANTAASKASRKQRSGSVIGKYVDGRGILRSQSEEEEDVFSAPRRRSSVGLSAYLQAEEDLGTGEPGSGVPRRQALRRIISIEEDPLPQLLEGGFEKPLSRCPEEEEVSDQGTERQSVAAPVLDLIPTSPRGQPVGKETLYKEERVPSTPDRLFKIVFVGDSAVGKTSFLRRLCEARFSPGMAATVGIDYRVKTVTVDNAQVALQLWDTAGQERYRCISQQFFRKADGVAVMYDLTAKQSFLSIRQWLSSVEEAVGDRIPVLLLGNKLDNEKEREVPRGLGEQLAKENNLIFYECSACSGHNAQESLLHLARLLKEQEDTVRNDTIQVGPPAKKKSCCG
Protein: Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36) (Q86VN1)
Organism: Homo sapiens (Human)
Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
Subcellular location: Cytoplasm. Endosome. Late endosome {ECO:0000250|UniProtKB:Q91XD6}. Membrane. Nucleus {ECO:0000305}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. {ECO:0000250|UniProtKB:Q91XD6}.
Interaction partners:
- Vacuolar protein-sorting-associated protein 25
- Charged multivesicular body protein 6
- Vacuolar-sorting protein SNF8
- Vacuolar protein sorting-associated protein 28 homolog
- Tumor susceptibility gene 101 protein
- Charged multivesicular body protein 3
- Charged multivesicular body protein 2a
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-C
Sequence:
MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDAGTLLLSTHRLIWRDQKNHECCMAILLSQIVFIEEQAAGIGKSAKIVVHLHPAPPNKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVSQSLQTNRGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMIKAKEMVELSKSIANKIKDKQGDITEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQVPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEALKLPLRLRVFDSGVMVIELQSHKEEEMVASALETVSEKGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQS
Protein: Serine/threonine-protein phosphatase alpha-2 isoform (EC 3.1.3.16) (P12982)
Organism: Drosophila melanogaster (Fruit fly)
Function: Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase.
Subcellular location: Cytoplasm.
Interaction partners:
- Protein phosphatase 1 regulatory subunit 12B
- GH07711p
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- LD24014p
- Myosin regulatory light chain sqh
- Serine/threonine-protein phosphatase beta isoform
- WD repeat-containing protein 82
- FI19335p1
- Nuclear inhibitor of protein phosphatase 1
- Protein phosphatase 1 regulatory subunit
Sequence:
MGDVMNIDSIISRLLEVRGARPGKNVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADKRKK
Protein: Nuclear receptor subfamily 1, group H, member 3 (Oxysterols receptor LXR-alpha (EC 3.4.13.9)) (A0A0R4IVP0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
- Retinoic acid receptor RXR-alpha-A
- P-type phospholipid transporter
- Retinoic acid receptor RXR-beta-A
- Peroxisome proliferator-activated receptor gamma
- Nuclear receptor coactivator 1.
- ATP-binding cassette, sub-family G
- Sterol regulatory element-binding transcription factor 1.
- Nuclear receptor coactivator 2
- Nuclear receptor corepressor 2
- Nuclear receptor coactivator 3
Sequence:
MSTLSATDITDVGHGDSLGCDSEEGPSAAMAEVKQEILSQTDLYNTSHDDLNDSMLMESNDIKMFFREDKAAPEGQPVKRKKGPAPKMLGNEVCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAQYSCKNSGRCEMDMYMRRKCQQCRLRKCREAGMLEQCVLSEEQIRLKKMKKQEEETARTSTVATPSPAPEMPPLAPEQQEMIEKLVAMQKQCNKRSFIDRPKVTPWPQSQDPQNREVRQQRFAHFTELAIMSVQEIVDFAKQLPGFLELTREDQIALLKTSTIEIMLLETSRRYNPAIDSITFLKDFTYNKEDFAKAGLQLEFINPIFEFSKGMNDLHLDEAEYALLIAINIFSADRPNVQDHELVERLQQPYVDALHSYIRIKRPNDHLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Protein: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein (F4JLV7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
Sequence:
MNPKCSKTTLALFFAFTILLIGHAESNSRPRPRTPPPPRTPRTPSPPPPRTPKTPPPPPPRTPRTPPPPPPRTPRTPPPPPPRTPRTPPTAPPRTPPVSPRIPPILPPKTPPTAPPQTPPVSPPKSPPNSPPRAPPLSPPRTPPTSPPRVPPLSPPRTPPTSPPRAPPIPPPRTPSTSPPRAPPLSPPRTPPTSPPRAPPVPPPNTPPTSPPRAPPLSPPRTPPNSPPRTPPTSPPRAPPVPPPRISPTAPPRAPPLSPPRTPPTSPPRTPPLSPPITPPTSPPRAPPLSPPRTPPTSPPRAPPISPPRTPPSSPPRAPPMPPPRTPPTSPPLSPLSPPPRSPPMPPTRTPPVSPPTSPSRTPPVTPPRAPPTAPPQTPPVSPPIVPPNSPPKRPPMSPPITPPTSPPRAPPQSPPITPPISPPRAPPTPPGTPSVPPPPRTPPPPPPSGRCPRNGIPLQICSTILNMFDGFLGLGTAQPCCSLIRGLSDADALACLCESVRAPSRSLPRNIINLFMTCGRSIPPGFTCP
Protein: Uncharacterized MFS-type transporter C1271.10c (O94343)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEPDGYVEELPGTILIYKENQYAASEHSVLKKDGDIVLQPQPSDDPNDPLNWNKFRKNWHLVLICLVSLVTGAIANDAGSAQDQMNAELGISYDAMDNAAGVLFICVGYFTYLAMPATFLYGRRCVYLVCLLFGMLGSMWFALVKTTSNSIGNQAFIGISEACAEALTQFSVSEVFFEHERGIKIGIYILSTSVGTYLGPLAAGYIASSQGWRWIGWWGLIISGITFVLFLFTFEETTFDRAAAIDRKQIQISNDQLTVKEDFDLKDMQSDIKPDVEKSDAMDDSKMKVDYTVNEISNAVQPIYSKPSYWKRIALITPANSLSGIGFRQYIMRLFQTLRIFLFPAVLYSGLQWGAQDAWLSFYLTTEEEDWMEAPYNYGDNAVAIMNVPCIIGATIGCIYGGYFGDYFTLWAAKRNNGIKEAESRLWLMILPCIINPIGLFMFGIGTARHWHWGPTYVGLGFIGFGWGCAGDISMAYLMDAYPGMVLEAMVGVSVINNTFGYVFTFACQSWIDSLGTERTYISIGVLCFIFIATSFPMILCGKRLRKWTAKQYYTFLNVRNRLDEKIPDQDRRGQDGVESR
Protein: SR-CI (Q5ELS3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEFFWTLAVIVIYCIGHIHGRCERSLDLDNGSINYRPRNIVRFRCNRGYTLQGTVMQTCDRDGRLRGEKPFCASRGCARPEDPENGHVENLSLRADVMCHDGYVLVGGRTAYCDGERWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFSTTTEPTAPTGSNEQPLVYDMMSCSGRCGTSISASNITNNGIVMGCGCNDECLSDETCCLNYLEECTKEMLTTTEDDISSLPPTVTSTSTSTTRKSTTTTTTSTTTTSTTTTKRPTTTTTTTKATTTKRTTTTKKPTTTSTTPKPTTTTSTTPKSTTSTTSTTSTTPTTTTTINVFTTKKTTTMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIEGHMDTSGSTPNPALVVLYLLLGIVLVVVLANVVNRWIIPITGSKTSSEKAVRFKKAFDSLKKQRKRNSMDDQPLCDSDNDDVEYFEEMGVDIRHRTDL
Protein: 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase (EC 6.3.2.55) (Staphyloferrin B biosynthesis protein SbnF) (Q2G1M8)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Catalyzes the condensation of L-2,3-diaminopropionic acid (L-Dap) and citryl-diaminoethane to form L-2,3-diaminopropionyl-citryl-diaminoethane, the third step in staphyloferrin B biosynthesis.
Interaction partners:
- 2-[
- Staphyloferrin B synthase
- L-2,3-diaminopropanoate--citrate ligase
- N-
- ATP-dependent L-serine kinase SbnI
- N-
- Staphyloferrin B transporter
- HpcH/HpaI aldolase/citrate lyase domain-containing protein
Sequence:
MIVVQTLFIHIYQIQFVITRRYRIVNQTILNRVKTRVMHQLVSSLIYENIVVYKASYQDGVGHFTIEGHDSEYRFTAEKTHSFDRIRITSPIERVVGDEADTTTDYTQLLREVVFTFPKNDEKLEQFIVELLQTELKDTQSMQYRESNPPATPETFNDYEFYAMEGHQYHPSYKSRLGFTLSDNLKFGPDFVPNVKLQWLAIDKDKVETTVSRNVVVNEMLRQQVGDKTYEHFVQQIEASGKHVNDVEMIPVHPWQFEHVIQVDLAEERLNGTVLWLGESDELYHPQQSIRTMSPIDTTKYYLKVPISITNTSTKRVLAPHTIENAAQITDWLKQIQQQDMYLKDELKTVFLGEVLGQSYLNTQLSPYKQTQVYGALGVIWRENIYHMLIDEEDAIPFNALYASDKDGVPFIENWIKQYGSEAWTKQFLAVAIRPMIHMLYYHGIAFESHAQNMMLIHENGWPTRIALKDFHDGVRFKREHLSEAASHLTLKPMPEAHKKVNSNSFIETDDERLVRDFLHDAFFFINIAEIILFIEKQYGIDEELQWQWVKGIIEAYQEAFPELNNYQHFDLFEPTIQVEKLTTRRLLSDSELRIHHVTNPLGVGGINDATTISET
Protein: Trafficking protein particle complex subunit 2L (H3BPN3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
Interaction partners:
Sequence:
MAVCIAVIAKENYPLYIRSTPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKLTFRARH
Protein: Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) (Q9NZ09)
Organism: Homo sapiens (Human)
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:21757351}. Endosome {ECO:0000269|PubMed:21757351}. Note=Predominantly cytosolic (PubMed:21757351). Recruited to endosomes as part of the ESCRT-I complex (PubMed:21757351). {ECO:0000269|PubMed:21757351}.
Interaction partners:
- Vacuolar protein sorting-associated protein 28 homolog
- Vacuolar protein sorting-associated protein 37A
- Tumor susceptibility gene 101 protein
- Tyrosine-protein phosphatase non-receptor type 23
- Vacuolar protein sorting-associated protein 37B
- Multivesicular body subunit 12A
- Charged multivesicular body protein 4a
- Multivesicular body subunit 12B
- Vacuolar protein sorting-associated protein 37C
- Vacuolar protein-sorting-associated protein 36
Sequence:
MASKKLGADFHGTFSYLDDVPFKTGDKFKTPAKVGLPIGFSLPDCLQVVREVQYDFSLEKKTIEWAEEIKKIEEAEREAECKIAEAEAKVNSKSGPEGDSKMSFSKTHSTATMPPPINPILASLQHNSILTPTRVSSSATKQKVLSPPHIKADFNLADFECEEDPFDNLELKTIDEKEELRNILVGTTGPIMAQLLDNNLPRGGSGSVLQDEEVLASLERATLDFKPLHKPNGFITLPQLGNCEKMSLSSKVSLPPIPAVSNIKSLSFPKLDSDDSNQKTAKLASTFHSTSCLRNGTFQNSLKPSTQSSASELNGHHTLGLSALNLDSGTEMPALTSSQMPSLSVLSVCTEESSPPNTGPTVTPPNFSVSQVPNMPSCPQAYSELQMLSPSERQCVETVVNMGYSYECVLRAMKKKGENIEQILDYLFAHGQLCEKGFDPLLVEEALEMHQCSEEKMMEFLQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLMARAGAS
Protein: Transmembrane protein 74 (Q8BQU7)
Organism: Mus musculus (Mouse)
Function: Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction (By similarity).
Subcellular location: Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MELHSLSKRNSPVDPCNALEWSSGETSGDHIEEATIRDAFCYQKNLVSTPRADVVEVCRLSTSPASPTSLLQDSAIQTSFSLSGPPDSGNNQVMADRKVCNCCSQELETSFTYVDENVNLEQRSQRSPSAKGSNHPVDLGWGNPNEWSHETAMSLMSEDDDDTSSEATSSGKSVDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLEKESAMLGAHLDRCVIAGLCLLTLGGVVLSCLLMMSMWKGELYRRNRFASSKESAKLYGSFNFRMKTSTNEDTLELSLVEEDALAVQS
Protein: High-affinity branched-chain amino acid transport ATP-binding protein BraG (P21630)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids.
Subcellular location: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- High-affinity branched-chain amino acid transport system permease protein BraD
- High-affinity branched-chain amino acid transport system permease protein BraE
- Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein
- Amino acid binding protein
- Probable permease of ABC branched-chain amino acid transporter
- High-affinity branched-chain amino acid transport ATP-binding protein BraF
- Branched chain amino acid ABC transporter membrane protein
- High-affinity branched-chain amino acid transport ATP-binding protein
- Probable amino acid binding protein
- Aliphatic amidase expression-regulating protein
Sequence:
MLSFDKVSTYYGKIQALHDVSVEVKKGEIVTLIGANGAGKSTLLMTLCGSPQAASGSIRYEGEELVGLPSSTIMRKSIAVVPEGRRVFSRLTVEENLAMGGFFTDKDDYQVQMDKVLELFPRLKERYEQRAGTMSGGEQQMLAIGRALMSKPKLLLLDEPSLGLAPIIIQQIFEIIEQLRREGVTVFLVEQNANQALKLADRAYVLENGRIVMHDTGAALLTNPKVRDAYLGG