wanglab/gogpt-training-data huggingface dataset:
Protein: Interleukin 1 receptor accessory protein (Q70YG5)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Interleukin-1 receptor type II
- Interleukin-1
- Interleukin-1
- Interleukin-1 receptor type I
- Interleukin-1 receptor type 1-like
- Interleukin-1 receptor type 1-like
- Interleukin-1 receptor-like 1
- ST2L protein isoform X1
- Myeloid differentiation primary response protein MyD88
- Interleukin-1 receptor-associated kinase 1-like isoform X1
Sequence:
MALFITALLSLSVAMVGVGGATPATTPSSVHSVIQCHDWGESGDGAVRVMEGEACWLLCPLFSHPTVYNYSSVQAAGLNLVWYHVAAGQDLEQPIDFHHPDQRLSKEREKLWLQPTTMQDAGQYICMLRNRTSCAKIAVRLEVLPSGQDPNCEVKAAVPPTPVIAPIQEGRTLTCPDLEDIKLPNTSHSVTWYHECNAFGNFNIDRVFKGDKLVIHVMLEHYQGLYHCVVTYETKGRAIKFTRVVNVTAVSSSGLPKQPNILNPAKEQLYPVKQGSEVTLICRVSLPYLEGPRETWWTIDGKTVDQLADPRISFTSRVVLNYFGDWTVENVLRIQDFSSEDLTREYNCSGRNGRDVATRRAVLEEEVYLPSVELGCGLGVTLFLMLVLFVVYHIFWLELLLLYRSWFGTDERCTDDKEYDIYISYARNSEEEQFVLLTLRRVLENELGYTVCIFDRDSLPGGTITDETLTFVGRSRRVLVVLSPGYGLQGTQALLELKAGLDSMAWGGHLRVILVQYKPLRRGGWVRELRRARVALALVRWQGDKSSDLSSRFWKRLRVELPVRRIKD
Protein: Myosin IC (F5H6E2)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, stereocilium membrane {ECO:0000256|ARBA:ARBA00004289}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSFLLNLRRQLPQNVLDTSWPTPPPALREASELLRELCIKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQRADNKQKGDVVLQSDHVIETLTKTALSANRVNSININQGSITFAGGPGRDGTIDFTPGSELLITKAKNGHLAVVAPRLNSR
Protein: Protein transport protein SEC24 (Abnormal nuclear morphology 1) (P40482)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SEC24 specifically recruits cargo proteins like BET1 or SYS1 to the COPII vesicles. The SEC23/24 complex is also involved in internalization of plasma membrane proteins like the maltose transporter.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8548805}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10720463, ECO:0000269|PubMed:10753972, ECO:0000269|PubMed:11086000, ECO:0000269|PubMed:12235121, ECO:0000269|PubMed:8548805, ECO:0000269|PubMed:9568718}; Peripheral membrane protein {ECO:0000269|PubMed:11086000, ECO:0000269|PubMed:8548805}; Cytoplasmic side {ECO:0000269|PubMed:8548805}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10712514, ECO:0000269|PubMed:8548805}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane {ECO:0000305|PubMed:8548805}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Protein transport protein SEC13
- Protein transport protein SEC23
- Protein transport protein SEC31
- Small COPII coat GTPase SAR1
- COPII coat assembly protein SEC16
- SED5-binding protein 3
- Protein transport protein SEC22
- Protein transport protein BET1
- SED5-binding protein 2
- GTPase-activating protein NEL1
Sequence:
MSHHKKRVYPQAQLQYGQNATPLQQPAQFMPPQDPAAAGMSYGQMGMPPQGAVPSMGQQQFLTPAQEQLHQQIDQATTSMNDMHLHNVPLVDPNAYMQPQVPVQMGTPLQQQQQPMAAPAYGQPSAAMGQNMRPMNQLYPIDLLTELPPPITDLTLPPPPLVIPPERMLVPSELSNASPDYIRSTLNAVPKNSSLLKKSKLPFGLVIRPYQHLYDDIDPPPLNEDGLIVRCRRCRSYMNPFVTFIEQGRRWRCNFCRLANDVPMQMDQSDPNDPKSRYDRNEIKCAVMEYMAPKEYTLRQPPPATYCFLIDVSQSSIKSGLLATTINTLLQNLDSIPNHDERTRISILCVDNAIHYFKIPLDSENNEESADQINMMDIADLEEPFLPRPNSMVVSLKACRQNIETLLTKIPQIFQSNLITNFALGPALKSAYHLIGGVGGKIIVVSGTLPNLGIGKLQRRNESGVVNTSKETAQLLSCQDSFYKNFTIDCSKVQITVDLFLASEDYMDVASLSNLSRFTAGQTHFYPGFSGKNPNDIVKFSTEFAKHISMDFCMETVMRARGSTGLRMSRFYGHFFNRSSDLCAFSTMPRDQSYLFEVNVDESIMADYCYVQVAVLLSLNNSQRRIRIITLAMPTTESLAEVYASADQLAIASFYNSKAVEKALNSSLDDARVLINKSVQDILATYKKEIVVSNTAGGAPLRLCANLRMFPLLMHSLTKHMAFRSGIVPSDHRASALNNLESLPLKYLIKNIYPDVYSLHDMADEAGLPVQTEDGEATGTIVLPQPINATSSLFERYGLYLIDNGNELFLWMGGDAVPALVFDVFGTQDIFDIPIGKQEIPVVENSEFNQRVRNIINQLRNHDDVITYQSLYIVRGASLSEPVNHASAREVATLRLWASSTLVEDKILNNESYREFLQIMKARISK
Protein: Ribonuclease E (RNase E) (EC 3.1.26.12) (Q3IHD2)
Organism: Pseudoalteromonas translucida (strain TAC 125)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00970}. Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00970}; Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_00970}; Cytoplasmic side {ECO:0000256|HAMAP-Rule:MF_00970}.
Interaction partners:
- Polyribonucleotide nucleotidyltransferase
- Transcription termination factor Rho
- ATP-dependent RNA helicase RhlB
- Ribonuclease R
- Ribonuclease PH
- Enolase
- Nucleotide-binding protein PSHAa2554
Sequence:
MKRMLINATQQEEMRVALVDGQRLYDLDIESPGHEQKKANIYKGKITRIEPSLEAAFVEYGADRHGFLPLKEIARTYFPAGYTFHGRPNIRDVIKEGQEVIVQVDKEERGQKGAALTTFISVAGSYLVLMPNNPRAGGISRRIEGDERTELKESLSRLELPKGMGLIVRTAGVGKSFEELNYDLKALLVHWEAIGVAADSAKAPFLIHQESNVIFRAIRDYLRRDIGEILIDKPRVFEEAKAHIERFRPDFMSRVKLYQGDTPLFTHYQIESQIESAFQREVRLPSGGSIVIDPTEALTSIDINSSKATKGGDIEETALNTNLEAADEIARQLRLRDLGGLIVIDFIDMTPPRHQREVENRLKDAVRPDRARVQIGKISRFGLLEMSRQRLRPSLGEASQGPCPRCSGQGTIRSNESIALSILRLIEEEAIKDNTAQVNAQVPVAVAAYLLNEQRRSVHRMEKQHKCDIVIIPNQHMETPHYEVMRLRKDETIETVSYGQIVAPEPEAFEMSKSPVAPVREEPMLKGVVMPAAPAPQAAPANVVAPAETKAQSGLLDAIGKWFKSLFASETVEVKKEETQKQQQETRDNTRNNDNRRRNNNNQRRRNNPRSKPRTERTADEEVKTNSVSTPEAATQTNENQERGENRNKRRRNPNSRKRPEPRTEDKDAVKVDAPAKAEAETKPVQAEEPKDQKPKVRRQRRNLRKKVRLQDENAEQVQTTDETPVQATEKETPVAQEQAPVVEKQTQTAAEKTAHIKEEKVEDVDSNDETPTTEDEQEQTRTRSRRSPRHLRASGQRRRRPEGEGNEAKSDEAPAFVPVADQAAAEYEAELKAKSAATPADAAQQVEQAVAVEDLAKVEAVEEPVQTEEPAKVETPVVTEEPAKVETPVAAEEPAKVETPVAAEEPAKVEAPVVTEEPAKVETPLVTEEPAKVEAPVVTEEPAKVETPVVTEEPAKVEAPVVTEEPTKVETPVVTEEPTKVEAPVVTEEPAKVETPVVTAAPHVKTAIAQGSASAPMAQPTPVADSEVKHTSVAMAHDKRELVPDSGLRAGSIKPAGRASSTMTKTMSVD
Protein: Cystine/glutamate transporter (Amino acid transport system xc-) (Solute carrier family 7 member 11) (Subtle gray protein) (xCT) (Q9WTR6)
Organism: Mus musculus (Mouse)
Function: Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (Probable). Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for protection of cells from oxidative stress. The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine. In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis (By similarity). Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis (By similarity). In vitro can also transport L-aspartate (By similarity). May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons. Controls the production of pheomelanin pigment directly.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9UPY5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UPY5}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:Q9UPY5}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the microvillous membrane of the placental syncytiotrophoblast. {ECO:0000250|UniProtKB:Q9UPY5}.
Interaction partners:
- Amino acid transporter heavy chain SLC3A2
- CD44 antigen
- Phospholipid hydroperoxide glutathione peroxidase GPX4
- Beclin-1
- Cellular tumor antigen p53
- Amino acid transporter heavy chain SLC3A1
- Excitatory amino acid transporter 2
- Long-chain-fatty-acid--CoA ligase 4
- Neutral amino acid transporter B
Sequence:
MVRKPVVATISKGGYLQGNMSGRLPSMGDQEPPGQEKVVLKKKITLLRGVSIIIGTVIGSGIFISPKGILQNTGSVGMSLVFWSACGVLSLFGALSYAELGTSIKKSGGHYTYILEVFGPLLAFVRVWVELLVIRPGATAVISLAFGRYILEPFFIQCEIPELAIKLVTAVGITVVMVLNSTSVSWSARIQIFLTFCKLTAILIIIVPGVIQLIKGQTHHFKDAFSGRDTSLMGLPLAFYYGMYAYAGWFYLNFITEEVDNPEKTIPLAICISMAIITVGYVLTNVAYFTTISAEELLQSSAVAVTFSERLLGKFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVHKHTPLPAVIVLHPLTMVMLFSGDLYSLLNFLSFARWLFMGLAVAGLIYLRYKRPDMHRPFKVPLFIPALFSFTCLFMVVLSLYSDPFSTGVGFLITLTGVPAYYLFIVWDKKPKWFRRLSDRITRTLQIILEVVPEDSKEL
Protein: PRA1 family protein B4 (AtPRA1.B4) (O80915)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18583532}; Multi-pass membrane protein {ECO:0000269|PubMed:18583532}.
Interaction partners:
- PRA1 family protein A2
- PRA1 family protein A3
- PRA1 family protein H
- PRA1 family protein A1
- Signal peptidase complex subunit 3B
- AT5g66780/MUD21_2
- Ethylene-responsive transcription factor ERF096
- U-box domain-containing protein 18
- Beta-galactosidase 13
Sequence:
MASSAPPVLPISNPQTVPSAAPSSVESQPPIATPAFRNFINQITETVKNGLSKRRPWAELADRSALSKPESISDAAVRIRKNYSYFKVNYLTVATAIVGFSLVTHPFSLVFLLCLLASWLFLYLFRPTDQPIVLFGRTFSDRETLGCLILFSIFVIFLTDVGSVLVSAMMIGVALICAHGAFRAPEDLFLDEQEPAATGFLSFLGGAASSAAPAVIAARV
Protein: Dehydrodolichyl diphosphate synthase 6 (Dedol-PP synthase 6) (EC 2.5.1.-) (Q8S2T1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein.
Interaction partners:
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Protein farnesyltransferase subunit beta
- Protein RETICULATA-RELATED 2
- Alpha-humulene/
- Farnesyl pyrophosphate synthase 1, mitochondrial
- Farnesyl pyrophosphate synthase 2
- Inactive squalene synthase 2
- Phytoene synthase 1, chloroplastic
- Squalene synthase 1
- Putative geranylgeranyl pyrophosphate synthase 8, chloroplastic
Sequence:
MAELPGQIRHIGGRMSQLLEQIYGFSRRSLFRVISMGPIPCHIAFIMDGNRRYAKKCGLLDGSGHKAGFSALMSMLQYCYELGIKYVTIYAFSIDNFRRKPEEVESVMDLMLEKIKSLLEKESIVHQYGIRVYFIGNLALLNDQVRAAAEKVMKATAKNSRVVLLICIAYNSTDEIVQAVKKSCINKSDNIEASNYKHEDSDSDIEGTDMENQEKKIQLVDIEENMQMSVAPNPDILIRSSGETRLSNFLLWQTGNTQLCSPAALWPEIGLRHLLWAILNFQRNHSYLEKRKKQL
Protein: Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) (Q3V129)
Organism: Mus musculus (Mouse)
Function: May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.
Interaction partners:
- Suppressor of fused homolog
Sequence:
MENFVLYEEIGRGSRTVVYKGRRKGTINFVAILCTEKCKRPEITNWVRLTHEIKHKNIVTFHEWYETSNHLWLVVELCTGGSLETVIAQDENLPEDVVREFGVDLVTGLHHLHRLGILFCDLSPGKILLEGPGTLKFSNFCLAKVAGESLEEFFALVAAEEGGGDSGENALKKSMKTRVRGSLIYAAPEIVKGTEFSVTSDLWSLGCLLYEMFSGKPPFFSETVSELVEKILYEDPLPPIPKDSSFPKASSDFLNLLDGLLQKDPQKRFSWEGVLQHPFWKDALRGEDSGWASEDSPFSRNVMECSGPHDSRELLQSPKNGQAKGQKAAHRLSQSFRLENPTELRPKSIMGGQLNESIFLLSSRPTPRTSAMVELNPGEGEDPSSPQKTSPLSKMTSGHLSQGALESQMRELIYTDSDLVITPIIDNPKIMKQPAIKFDPKILHLPAYSVEKLLVLKDQDWNDFLQQVCSQIDSSEKSTGALRAKLNLLCYLCVVATHKEVATRLLHSPLFQLLIQHLRIAPNWDIRSKVARVVGMLALHTTELQENVPVIEAITLLTELIRENFRSGKLKQCLLPTLGQLLYLVATQEEKNQHSRDCWAVPLAAYTVLMRCLREGEERVVNHMAAKIIENVCTTFSAQAQGFTTGEIGPVLWHLFRHSTVDALRITAISALCRITRQSPTAFQNVIEKVGLNAVISSLASAICKVQQYMLTLFTAMLSCGIHLQRLIQEKDFVSTVIRLLDSPSTPIRAKAFLVLLYILIHNRDMLLLSCQARLVMYIERDSRKTSPGKEQQSGNEYLARCLDLLIQHMVQEPPRILGDILNALANVSGRKHPSTVQGKQLKMCLPMMPVVLHLVMSQVFRPQVVTEEFLFSYGTILSHIKSIDLGETNIDGAIGIVASEEFIKVTLSAFEAVIQYPVLLADYRSTVMDYILPPLVSLVQSQNVEWRLFSLRLLSETTTLLVSQEPEDGDEEASCDSDSSLLALIRDELLPQYEHILMEPDPVPAYALKLLVAMTEHNPAFTRLVEESKLVPLIFEVILEHQESILGNTMQSVIALLNNLVAYKDSNMQLLYEQGLVGHVCNMFTETATLCLDRDNKTNTEPASTLLASLLDILLGMLTYTSRIVRQALQVQKSGSRGDTQAAEDLLLLSKPLTDLISLLIPLLPSEDPEISEVSSKCLSILVQLYGGENPESLSPENMVTFANLLMTKEDPKDQKLLLRILKRMVTSNERLLESLKNTGSLLQALERLAPAHRLRGPWAGISCALFQQRAAAQGIPELPPYGIPCCGPSHKRVTGVKLYPC
Protein: Uncharacterized protein C8orf74 (Q6P047)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MALLTPQGVKEVFQLQRPQGRERLRRLLNWEEFDEQRDSRRSILLDTLYESIIFAVGKGFPWVEVAQVVKFTEELLRETKGCSITEAVTILGNKLRDYRGHFNTTHLLALCDYFHHTFIRHYKLYQYVLGQDQQVDLTVAHLEVCMPPHPLPLAEGMDRDLWIHEQQVATLTEAEAQKRADVLLLKEALRLERENSLQKAFAAAAPAQPGQVLERQELESLICQAVHTQMELLQELLQRQIQNTFAILDLKLQKKTLNLNAPTPIPPPITSHAGQEEALKPQRASKGKKAKARK
Protein: Protocadherin gamma-B4 (PCDH-gamma-B4) (Cadherin-20) (Fibroblast cadherin-2) (Q9UN71)
Organism: Homo sapiens (Human)
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MGSGAGELGRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDITDRPDPSDLQAELQFYLVVALALISVLFLVAMILAIALRLRRSSSPASWSCFQPGLCVKSESVVPPNYSEGTLPYSYNLCVAHTGKTEFNFLKCSEQLSSGQDILCGDSSGALFPLCNSSELTSHQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Protein: Wolframin (P56695)
Organism: Mus musculus (Mouse)
Function: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (By similarity). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O76024}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:O76024}. Note=Co-localizes with ATP6V1A in the secretory granules in neuroblastoma cell lines. {ECO:0000250|UniProtKB:O76024}.
Interaction partners:
- Cyclic AMP-dependent transcription factor ATF-6 alpha
- Cyclic AMP-dependent transcription factor ATF-6 beta
- CDGSH iron-sulfur domain-containing protein 2
- Transmembrane protein 214
Sequence:
MNSGTPPPSPSGPPPPPAPQPQARARLNATASLEQDKIEPPRAPRPQADPSAGRSAGEAAAPEPRAPQTGSREETDRAGPMKADVEIPFEEVLEKAKAGDPKAQTEVGKHYLRLANDADEELNSCSAVAWLILAAKQGRREAVKLLRRCLADRKGITSENEAEVKQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVSELLENVGQVNEQDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGIIPTNLFLQDEDEDEDELAGKSPEDLPLRQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTIVPTHHINALIFFFIISNLTIDFFAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVISTFFTVTSYMSLSSSAEPYTRRALVTEVAAGLLSLLPTVPVDWRFLKVLGQTFFTVPVGHFIILNVSLPCLLYVYLFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIGYFLFLFALPILVAGLALMGTVQFARWFLSLDLTKIMVTTVICGVPLLFRWWTKANFSVMGMVKSLTKSSMVKLILVWLTAILLFCWFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTEIDNSAESAINMLPFFLGDWMRCLYGEAYPSCSSGNTSTAEEELCRLKQLAKHPCHIKKFDRYKFEITVGMPFGTNGNRGHEEDDITKDIVLRASSEFKDVLLNLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMTQLSPARRHVKIEQDWRSTVHGALKFAFDFFFFPFLSAA
Protein: ABC transporter, periplasmic substrate-binding protein (Q5LWK7)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Interaction partners:
- ABC transporter, permease protein
- ABC transporter, ATP-binding protein
- Aminopyrimidine aminohydrolase
- Thiamine biosynthesis protein ThiS
- Thiamine-phosphate synthase
- D-amino-acid oxidase
- Thiazole synthase
- hydroxymethylpyrimidine kinase
- ABC transporter, permease protein
- Sulfonate ABC transporter, permease protein, putative
Sequence:
MPPASGPGALRNSCNRFGRARSFSLRPPHHERKRDMKHLVTALALLAATPALAQDKMTLLLDWFINPDHGPIIVAQEKGYFAERGLEVEIVAPADPSAPPRLVAAGQADLAVSYQPQLHLQIHEGLPLKRVGTLVATPLNCLLVLDNGPIKSPADLKGKKIGFSVAGVEEAILTTVLGKYDVALSDVEMINVNFSLSPALMSGQVDAVIGAYRNFELNQMDIEGEPGRCFYIEEEGVPSYDELIYVANPDRMDAGKIARFLEATEKATQFIVNNPQASWEIFSATSPELQDELNKRAWADTLPRFALRPAGFDAGRYARFETFLKDSGMIDSVNSVSAITIDVTAE
Protein: Uncharacterized protein (Q389G3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Telomerase-associated protein, putative
Sequence:
MSSREERRNDTADENGEEEDELFEEEMEDEDHLTADRFSPVSNIGKESMSPSDRSRSINRSAELKSGKEKGVYSSLPPRKPDITEITMQLPGMGDDFMTVHVRLTPAIDLQPPKGNWLKEVEKDGEIDEEAQEEEEQGRDEEDEENEEEEDEEGDEDEDENGTVPRKRGGTQLGKGKKEANEEEEGDNEEEEENSDVNATKERLCPPWLLPLLSDDAFYWEHTLDKMFGYELPPSPNIDACGDPKSAIRRPRTSRDDGDGDAEDQTGDKLKTPEKVVITDAADDKSAASGDSSDADGDIREGELSTITVPTNQTSKQLEAQPRPARFSLQSSSSLGMNVQNQFPKRPVLRFTEASRLFYIVRSIGGKRWYLLDTLPMPEEESEEDVEEEAMEEVEEGEESEEDETNSASGSTETGDQNLDEEREKNVEDDQAKEPMEQAVGAQSDVDQVEEEEDDGGVPDASMLDMQSVICIDTLTLAALRCPAALRTCLVQKDPISLACIETWMRLDVNIALPILTTIYRTMLAIRAEAPRLPYSLPDWKFDYNIFLTSSYLAHRKPQYPRQTANLVSSTSQILAVVDSPCVGERQSYETMAGLLSVRTFPSKPILLQNLNHVVGMRLFVWLITEIPHHVLLQWASLKSSPPDSGRKDAETGSESDDGDDEEDEEGDGKKKAARYIASVVDAFWKRVPSVDGPYLILSPFLKAVVVEVRRRQRREREGFGASKYTLMECVAHALPKRIEDGKPKKDPLVASSFSLFPQNYGPPELSTPSPPDQRVYQSDLVILLLTLTTTPATRDATTVRTERLALGVRSHPRPLSYAPDGNYELLTYLLNKKTEKVRTPVEAVRSGYFRVLYLSLLRFVAPSSVMLLLSVTPLFSVMGPADRCPLPQLLHAWHIEWDFCFRGHLDHFINTFWNELYYRTLEKQFDDATVLRAKQLMLLEKVTERRNQYLFAIRQLNSRARPLSARAFVGFPVLVGEECEETLAISSTLEALPPIKPRKIIKSSEHPLNLSPYSEDWRHEEEHVRYMLASLPMAPRTYLTPETLHLLLFDVPHANRYAIHYLMRGCGVVQTQINPLKGAAVPAMEYALLTRNVEAVLMLLATGETLDDQMLGGMVNGEAWLYEAFRGRDAMRLLAVWRKKEQERKSDPDVRFGVLRTIPTSE
Protein: Ribosome-associated complex subunit SSZ1 (DnaK-related protein SSZ1) (Heat shock protein 70 homolog SSZ1) (Pleiotropic drug resistance protein 13) (P38788)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. SSZ1 is required for ZUO1 to function efficiently as a J-protein for SSB1/SSB2. Also involved in pleiotropic drug resistance by post-translational activation of transcription factor PDR1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Zuotin
- Mitochondrial protein import protein MAS5
- Transcription factor PDR1
- ATP-dependent molecular chaperone HSC82
- Pleiotropic ABC efflux transporter of multiple drugs
- ATP-dependent molecular chaperone HSP82
- Heat shock protein 104
- Protein SIS1
- Transcription factor PDR3
- Auxilin-like clathrin uncoating factor SWA2
Sequence:
MSSPVIGITFGNTSSSIAYINPKNDVDVIANPDGERAIPSALSYVGEDEYHGGQALQQLIRNPKNTIINFRDFIGLPFDKCDVSKCANGAPAVEVDGKVGFVISRGEGKEEKLTVDEVVSRHLNRLKLAAEDYIGSAVKEAVLTVPTNFSEEQKTALKASAAKIGLQIVQFINEPSAALLAHAEQFPFEKDVNVVVADFGGIRSDAAVIAVRNGIFTILATAHDLSLGGDNLDTELVEYFASEFQKKYQANPRKNARSLAKLKANSSITKKTLSNATSATISIDSLADGFDYHASINRMRYELVANKVFAQFSSFVDSVIAKAELDPLDIDAVLLTGGVSFTPKLTTNLEYTLPESVEILGPQNKNASNNPNELAASGAALQARLISDYDADELAEALQPVIVNTPHLKKPIGLIGAKGEFHPVLLAETSFPVQKKLTLKQAKGDFLIGVYEGDHHIEEKTLEPIPKEENAEEDDESEWSDDEPEVVREKLYTLGTKLMELGIKNANGVEIIFNINKDGALRVTARDLKTGNAVKGEL
Protein: Uncharacterized HTH La-type RNA-binding protein C1527.03 (Q9P6K0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Stress-responsive protein 1
- Polyadenylate-binding protein, cytoplasmic and nuclear
Sequence:
MSHKEPSAAETSTVVHSEEDKAFCIGTGAVISEEREKEVLKNLQNSLTGKTAEENLNDEANHTSSDKSKSEDYQPSNVNVWALRKEKMIPKKHSHVKQEKRFSKSLQLQDPNVWPSPEIAEKQVEDRKLSDDSQKPLAPKANGKEKWVTITPNFTHTPISNRKSSRSRNDGSRRNGNGRRRGNYSSHGSNKRQTNYSREKDASRSIDSSNPSAEYRDDINNTFGSQTVSSANGKEVPQTSEDSSSQAPHHSSSSGHAPSQQGGNKHSYKKSDSQQSFHHKGRNTRKGQRHNNGFYRNIANNIQGPFPNYPVVVNGNGVNPYLCDVQAFLTSQLEYYFSIENLCKDMFLRKHMDDEGYVPLAFLASFNRIKSFSTDLNLLHAACKASDIIDVAIDLQSPMSIKVRRKETWSPWILPSESRLKFEMAKYPQINSSSSMSPLASSISNLTISPPFIPSSVDSIIKRDVQTEVEDKLTV
Protein: Fife, isoform D (M9PE32)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
- Bruchpilot, isoform J
- Unc-13, isoform E
- Glutamate receptor 1
- RIM-binding protein, isoform F
Sequence:
MLPTNVMSFMKKMVATDEQTSERQQHAADSGGGASQTGALNKMKATISSSLLTVTDKVNKMSPRPSLVPTDADTSGSYGSPSYQSQQQQQQDYGSSLNNNNNNSSGGGTATTGGGGGGAAAKQEPGRRAGACRVCLKSFKPDDYHKTCFECQQRVCEDCASYSKLDEHEDATMWRCSVCRRKMASRVCIPQDSTDSMLDVPVLEALQRRHSDAKLGSSTQTLAPSNGAALAPPRSPELRRHSDVSPASLKELERQLKGGRSMAPSRSNSPPRGEGPDGQPPFGAPLSRMQSRRGSRVARQHSYDDDMKTGPVGGSMGGGGPALGLGADGAGLGIPTMPRRKSAYDVFAPGLTQGGATPATQLQRSPGEGGIMPPIQLPGSRRPSFRVPHPSEDIQNDDSPGSPDKGSPVLTVDDDRRMRRRGSQLPDIAMLQNRGALPAVPPSSIPPPMASFTGPNLEDLEAPRRQTSMDGEAIRIVIHDVDSGPICASKRRIILRRDPTDKAHRTRGFGMRVVGGKTGADGRLFAYIVWTVPGGAAEKNGLQQGDKILEWNGMSLIDRSFEEVCSIMDRTGDVVELLVEHATDFRMCDLFDENLPPGNAGGQSGPRRSGDGPVGLGLIAEPETTTDKSPASPTRRKLPKTPEQIAREKLVTGRVQIQVWYHAERSELVVSLMAGDDLAPRDEAYGHGNLPEAYAKVRILPKCGDGSVQQTEVSRPTQNPIWNATLTFGHVKADTLMVRYIDIQLWDLVPHTESIFLGECSIELQQAFLDDQAIWCRLEDTKGLRGISISKSPSVSPRGSIAAGAGAPSGDVTRLLRRDYNMQRSNSDDVDSIGDGTSLLHPDHAWIAGSRRGSSQSETMEVEVYQLGKDFSRSLPGSRRSSFQDAEKNRLEEDAMATPPTSYLVGRRRSSVARRDPDEILKSLKAVRGELGRTMSLGTEQHKRMGSRRASRVGLPSGPSSRKSSVLDLSQQHQQQLQQLQQLQLQQQQYLQQQLPMGVGNADTSPPSEDEDKRYRPRWKGSVSQLPPQSPKQALSRLKQAASASNVAQDTQRQGQLLTTNPLQQRKSSMFQLGESQASPPTTTTTHLQRKGSMYVAKVTETPPHGTPTRKGSVYQRSVVGLSVDSPGADSPQRKQSVVKTLSGSYVNICPLTGGESSYGLKLGPSQIHPKGYRLTTARYGELKMGFLKIKGNVEVELICARNIVNEDCETPPDTYVKCYIKDGDRLRHKKKTRVVRHAAEPLYRQTIKYQSSDVFGRNIVIMVWQRCVGFEHNQGLGGTEVNLDKLSIGQPISGWYPLFPMHSYGGSDSDNSP
Protein: Mago homolog B, exon junction complex subunit (F1M0X6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Protein CASC3
- RCG43312)
- RNA-binding protein 8A
- UPF3B, regulator of nonsense mediated mRNA decay
- Eukaryotic initiation factor 4A-III
- PYM homolog 1, exon junction complex associated factor
- Protein mago nashi homolog
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein Sm D3
- Aly/REF export factor
Sequence:
MALASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI