wanglab/gogpt-training-data huggingface dataset:
Protein: Heat shock 70 kDa protein 4 (Heat shock cognate 70 kDa protein 4) (Heat shock cognate protein 70-4) (AtHsc70-4) (Heat shock protein 70-4) (AtHsp70-4) (Q9LHA8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). ATP-dependent molecular chaperone that assists folding of unfolded or misfolded proteins under stress conditions. Mediates plastid precursor degradation to prevent cytosolic precursor accumulation, together with the E3 ubiquitin-protein ligase CHIP. Recognizes specific sequence motifs in transit peptides and thereby led to precursor degradation through the ubiquitin-proteasome system. Plays a critical role in embryogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:28004282}. Nucleus {ECO:0000269|PubMed:28004282}.
Interaction partners:
- E3 ubiquitin-protein ligase CHIP
- Heat stress transcription factor A-1a
- Heat shock protein 90-1
- Chaperone protein ClpB1
- Chaperonin CPN60, mitochondrial
- Hsp70-Hsp90 organizing protein 1
- Heat stress transcription factor A-2
- Protein SGT1 homolog B
- Hsp70-Hsp90 organizing protein 3
- Heat shock protein 90-5, chloroplastic
Sequence:
MAGKGEGPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPTNTVFDAKRLIGRRYSDPSVQADKSHWPFKVVSGPGEKPMIVVNHKGEEKQFSAEEISSMVLIKMREIAEAFLGSPVKNAVVTVPAYFNDSQRQATKDAGVISGLNVMRIINEPTAAAIAYGLDKKASSVGEKNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHFVQEFKRKNKKDITGNPRALRRLRTACERAKRTLSSTAQTTIEIDSLFEGIDFYTTITRARFEELNMDLFRKCMEPVEKCLRDAKMDKSSVHDVVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQAAILSGEGNEKVQDLLLLDVTPLSLGLETAGGVMTVLIPRNTTIPTKKEQIFSTYSDNQPGVLIQVYEGERARTKDNNLLGKFELSGIPPAPRGVPQITVCFDIDANGILNVSAEDKTTGQKNKITITNDKGRLSKEEIEKMVQEAEKYKAEDEEHKKKVDAKNALENYAYNMRNTIKDEKIASKLDAADKKKIEDAIDQAIEWLDGNQLAEADEFEDKMKELESLCNPIIARMYQGAGPDMGGAGGMDDDTPAGGSGGAGPKIEEVD
Protein: Ubiquitin-conjugating enzyme E2 8 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 8) (UBCAT4A) (Ubiquitin carrier protein 8) (Ubiquitin-conjugating enzyme E2-17 kDa 8) (Ubiquitin-protein ligase 8) (P35131)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.
Interaction partners:
- Ubiquitin-activating enzyme E1 1
- Membrane-anchored ubiquitin-fold protein 3
- E3 ubiquitin-protein ligase UPL4
- E3 ubiquitin-protein ligase UPL3
- E3 ubiquitin-protein ligase KEG
- Ubiquitin-like superfamily protein
- Ubiquitin-activating enzyme E1 2
- E3 ubiquitin-protein ligase PRT1
- CMP-sialic acid transporter 1
- Protein kinase family protein
Sequence:
MASKRILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPAESPYSGGVFLVTIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILKEQWSPALTISKVLLSICSLLTDPNPDDPLVPEIAHMYKTDRAKYEATARNWTQKYAMG
Protein: Vesicle-fusing ATPase (EC 3.6.4.6) (B7Z9U2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU367045}.
Interaction partners:
Sequence:
MTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQETEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFD
Protein: Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta) (Q9H115)
Organism: Homo sapiens (Human)
Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Synaptosomal-associated protein 25
- Vesicle-fusing ATPase
- Syntaxin-3
- Syntaxin-6
- Syntaxin-4
- Syntaxin-1B
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Synaptosomal-associated protein 23
- Syntaxin-12
- Syntaxin-5
Sequence:
MDNAGKEREAVQLMAEAEKRVKASHSFLRGLFGGNTRIEEACEMYTRAANMFKMAKNWSAAGNAFCQAAKLHMQLQSKHDSATSFVDAGNAYKKADPQEAINCLNAAIDIYTDMGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANTMDNPLLKYSAKDYFFKAALCHFIVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRLDQWLTTMLLRIKKSIQGDGEGDGDLK
Protein: Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) (Q54PV8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Probable plasma membrane ATPase
- Polyphosphate kinase
- ATP synthase subunit alpha
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase F
- ATP-dependent 6-phosphofructokinase
- V-ATPase proteolipid subunit C-like domain-containing protein
- ATP synthase subunit a
- V-type proton ATPase proteolipid subunit
- ATP synthase subunit 9, mitochondrial
Sequence:
MKNFFSFSKLTPHLKNIYHRNMTYTTKQVGETGSLEYRLFFLKDNKPVSSFHDVPLWVNKEKQIVNMLVEIPRGTNAKLEIATKEYMNPIKQDVKDGKLRFVHDKYPFNYGALPQTWESPEHTHPSTGAKGDNDPLDACEIGSGQGVTGEFKQVKVLGVFAMIDAGETDWKILCIDVNDPIASQINSQEDIEKHLPGKINEVYTFLRDYKIPDGKGPNQFAFDGKLQSIDFSMKIIEETEAEWKDLVGGKTKSSLSVVNTTLNDSNTVTADVAAQKLNF
Protein: Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic (AtG6PD2) (G6PDH2) (EC 1.1.1.49) (Q9FY99)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:21309870}.
Interaction partners:
- Glucose-6-phosphate isomerase 1, chloroplastic
- Glucose-6-phosphate isomerase, cytosolic
- 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic
- 6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic
- 6-phosphogluconate dehydrogenase, decarboxylating 2
- Probable 6-phosphogluconolactonase 1
- 6-phosphogluconolactonase 3, chloroplastic
- Probable 6-phosphogluconolactonase 5
- Probable 6-phosphogluconolactonase 4
- Probable 6-phosphogluconolactonase 2
Sequence:
MAALSSSVTTRSYHSGYLASFSPVNGDRHRSLSFLSASPQGLNPLDLCVRFQRKSGRASVFMQDGAIVTNSNSSESKTSLKGLKDEVLSALSQEAAKVGVESDGQSQSTVSITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYSRSKMTDVELRNMVSKTLTCRIDKRANCGEKMEEFLKRCFYHSGQYDSQEHFTELDKKLKEHEAGRISNRLFYLSIPPNIFVDAVKCASTSASSVNGWTRVIVEKPFGRDSETSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIRVEDVVIGQYKSHTKGGVTYPAYTDDKTVPKGSLTPTFAAAALFIDNARWDGVPFLMKAGKALHTRSAEIRVQFRHVPGNLYNRNTGSDLDQATNELVIRVQPDEAIYLKINNKVPGLGMRLDRSNLNLLYSARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWSLFTPLLKEIEEKKRIPEYYPYGSRGPVGAHYLAAKHKVQWGDVSIDQ
Protein: Flagellum-associated coiled-coil domain-containing protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog) (Q8BVM7)
Organism: Mus musculus (Mouse)
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:21402173}. Cytoplasmic granule {ECO:0000269|PubMed:21402173}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:21402173}. Note=Expressed in the principal piece of the sperm tail, nearest the sperm head. {ECO:0000269|PubMed:21402173}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:21402173}. Cytoplasmic granule {ECO:0000269|PubMed:21402173}.
Interaction partners:
Sequence:
MDPNPFIYCTCCDCCKLGQPKLIKTPYPLPKHPTGKFKPVLPPPISKEHNSLLSQPGKSTVSPRDKVQSGNTESSKAPSEVIQVSPGYTLIRNREQISVTLGDEMFNRKKHLESDVLSKVKFSRTDIISDLQEQIAELMAIIEQMNRDQQSALKLLSKDLDLRCSNMKQKFETESRELKETHREELERLENNYKEALKAEKALAEEKLDKMSKEYKYLKSMFHVFQDSIYEEMEDKWLRRKAEWEKDEKMEREKILLQQKCRIIKKFELQSEEKKKKMNESISAVSDNFAREKEELLRQHDEDILQIQELRKSKEILEAELRAQATVLETLNTNLFQCQKELERQKTIAANLEKLFQTKLAEAEEKHKYNIKTPTEENNCLRC
Protein: PR domain containing 2, with ZNF domain (Q8C2W5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MHQNTESVAVTETLAEVPEHVLRGLPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSK
Protein: Y' element ATP-dependent helicase protein 1 copy 3 (EC 3.6.4.12) (P0CX14)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Interaction partners:
- Y' element ATP-dependent helicase YML133C
- Putative uncharacterized protein YHR219W
Sequence:
MEIENEQICTCIAQILHLLNSLIITFLDDDKTETGQSFVYIDGFLVKKHNNQHTIVNFETYKNKMKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPDFQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCYEIASARPNDSSTMRTFTDFVSGTPIVRGLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETALKDSYRITLVPSSDGVSVCGKLFNREYVRGFYFACKAQFDNLWEELNDCFYMPTVVDIASLILRNREVLFREPKRGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMIHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDILLCRDSSREVGE
Protein: Probable ADP-ribosylation factor GTPase-activating protein AGD13 (ARF GAP AGD13) (Protein ARF-GAP DOMAIN 13) (AtAGD13) (Q8LFN9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTPase-activating protein (GAP) for ADP ribosylation factor (ARF).
Interaction partners:
- Tubby-like F-box protein 6
- Shaggy-related protein kinase beta
- Protein PLANT CADMIUM RESISTANCE 11
- F-box protein At3g62230
- Tubby-like F-box protein 7
- Transducin/WD40 repeat-like superfamily protein
- Pre-rRNA-processing ESF1-like protein
- Hydroxyproline-rich glycoprotein family protein
- Probable aquaporin TIP5-1
- Dynamin-related protein 3B
Sequence:
MSNYAAGLGKPGSGKRRIRDLLNQPDNRVCADCGASDPKWASANIGVFICLKCCGVHRSLGTHISKVLSVTLDEWSDEEVDSMIEIGGNASANSIYEAFLPDTCSKPGPDVNHDQRMRFIRAKYELQEFLKPSLRITSGKGSTKSSAFLTSSLSRKIMDSFRTNSSSQTMFQEGMVEFIGLLKVTIKKGTNLAIRDMMSSDPYVVLNLGKQKLQTTVMNSNLNPVWNQELMLSVPESYGPVKLQVYDYDTFSADDIMGEADIDIQPLITSAMAFGDPEMFGDMQIGKWLKSHDNPLIDDSIINIVDGKVKQEVQIKLQNVESGELELEMEWLPLDQ
Protein: Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) (P30531)
Organism: Homo sapiens (Human)
Function: Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse. The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P23978}; Multi-pass membrane protein {ECO:0000255}. Presynapse {ECO:0000250|UniProtKB:P31648}. Note=Localized at the presynaptic terminals of interneurons. {ECO:0000250|UniProtKB:P31648}.
Interaction partners:
- Gamma-aminobutyric acid receptor subunit delta
- Syntaxin-1A
- Putative protein CASTOR3P
- Gamma-aminobutyric acid receptor subunit alpha-5
- Glutamate decarboxylase 2
- Glutamate decarboxylase 1
- Protoporphyrinogen oxidase
- Parvalbumin alpha
- Vesicular inhibitory amino acid transporter
- Gamma-aminobutyric acid receptor subunit alpha-6
Sequence:
MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
Protein: Probable pectinesterase/pectinesterase inhibitor 41 [Includes: Pectinesterase inhibitor 41 (Pectin methylesterase inhibitor 41); Pectinesterase 41 (PE 41) (EC 3.1.1.11) (AtPMEpcrB) (Pectin methylesterase 41) (AtPME41)] (Q8RXK7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular location: Secreted, cell wall {ECO:0000250}.
Interaction partners:
- Serine carboxypeptidase-like 43
- EP1-like glycoprotein 1
- Pectinesterase inhibitor 3
- Probable polygalacturonase At2g43860
- Pectinesterase inhibitor 10
- ATPase family AAA domain-containing protein At1g05910
- Pectate lyase
- Pectate lyase
- Probable pectate lyase 12
- Probable pectate lyase 5
Sequence:
MLSLKLFLVTLFLSLQTLFIASQTLLPSNSSSTICKTTPDPKFCKSVFPQTSQGDVREYGRFSLRKSLTQSRKFTRTIDRYLKRNNALLSQSAVGALQDCRYLASLTTDYLITSFETVNITTSSKTLSFSKADEIQTLLSAALTNEQTCLDGINTAASSSWTIRNGVALPLINDTKLFSVSLALFTKGWVPKKKKQVASYSWAHPKNTHSHTKPFRHFRNGALPLKMTEHTRAVYESLSRRKLADDDNDVNTVLVSDIVTVNQNGTGNFTTITEAVNSAPNKTDGTAGYFVIYVTSGVYEENVVIAKNKRYLMMIGDGINRTVVTGNRNVVDGWTTFNSATFAVTSPNFVAVNMTFRNTAGPEKHQAVAMRSSADLSIFYSCSFEAYQDTLYTHSLRQFYRECDIYGTVDFIFGNAAVVFQDCNLYPRQPMQNQFNAITAQGRTDPNQNTGISIHNCTIKPADDLVSSNYTVKTYLGRPWKEYSRTVFMQSYIDEVVEPVGWREWNGDFALSTLYYAEYNNTGSGSSTTDRVVWPGYHVINSTDANNFTVENFLLGDGWMVQSGVPYISGLLS
Protein: Transcription factor Sp3 (O70494)
Organism: Mus musculus (Mouse)
Function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity).
Subcellular location: Nucleus. Nucleus, PML body {ECO:0000250}. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies (By similarity). {ECO:0000250}.
Interaction partners:
- Transcription factor Sp1
- Histone deacetylase 1
Sequence:
MTAPEKPVKQEEMAALDVDGGGGGGGHGEYLQQQQQQQQQHGNGAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDDEEAAVAAAAGVPAAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGSSDNGGINQENSQIQIIPGSNQTLLASGTPPANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNETNADTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTTSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAGRDDALITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME
Protein: Probable vesicular-fusion protein sec17 homolog (Q9P4X4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Vesicular-fusion protein sec18
- Syntaxin-like protein psy1
- Vesicle transport v-SNARE protein vti1
- Protein transport protein sec9
- Synaptobrevin homolog 1
- Protein transport protein sec22
- Protein sly1
- Syntaxin pep12
- Synaptobrevin homolog ykt6
- Integral membrane protein sed5
Sequence:
MIADPDQLMQKAAKKAQGTGGFALFGGGNKYDEASELFLDAANGYRLQKQGSAAGYAFEKAAEMQLKTDDKDDAASTYVEAFKSYRREKPSEAARVLQIAIELFTRRGNFRRAANYKMDLGDIFEQELQDTKAALGAYEDAGEWYSSDQADALANKAYLKAADLAGLCGEYSLAIRKFEQVARASVQNNLLKWSVKDYLLKAGLCYMANGDEIATRRALEHFLEIDPSFASTREYQLLKDLQDTIEASDANMFADKVFTYDQLSKLDSWKTTILLKIKSSIQEAEDDLT
Protein: Sterile20-like kinase, isoform G (EC 2.7.11.-) (A4UZU8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDETEKLKRQVKRRSLYQREPRNSALQLDLDDDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTKATTPDRPNHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKKPEDVAAVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPAASDSQTSPKKLATPEPTSPVTTAIEVAIGQEAMEPKPQPPSPTASSIVSVQSVASSSSSGSVSNAVLSSSTSLITINSDPPTPHHHQPLPPQPQHLILPNSLESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSNDMNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSSTVHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSNELVKRQPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVRGRRGIEVLVGGSGGSDVDSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSLTNNHNHETIDEEEEVVIRPKARVPAVVKSANAQGLTKEEIELRNLRKKTRKRTRKFEIDGVQMTTTTSRVIYGDDENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQDRRFEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIRLLKQEVDLFPKDKRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATINRNFLQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRMLQRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRYMQEERRFEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQLVPRKQQLQQRLQQERLEETFAQQLDEMETLYGGALIVSMPSDTLQRDHFTGSTRSSLSSYSEG
Protein: Uncharacterized protein (Q38AE8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRGSGSSVHSLTWLWDKMPVLVAEKARSNGPWRLRVSAALESTRRFVGERLGYCDISCEKGHQVDGNVWYAEQYLYPNHWQPGSGLRPKLVDDGESRTWLRAWARAVLVPLSILLFAFFLYISL
Protein: Potassium-transporting ATPase potassium-binding subunit (ATP phosphohydrolase [potassium-transporting] A chain) (Potassium-binding and translocating subunit A) (Potassium-translocating ATPase A chain) (P9WKF3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00275}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00275}.
Interaction partners:
- Potassium-transporting ATPase KdpC subunit
- Potassium-transporting ATPase ATP-binding subunit
- Sensor protein KdpD
- Probable membrane protein KdpF
- Transcriptional regulatory protein KdpE
- Bifunctional aminodeoxychorismate lyase / D-amino acid transaminase
Sequence:
MSGTSWLQFAALIAVLLLTAPALGGYLAKIYGDEAKKPGDRVFGPIERVIYQVCRVDPGSEQRWSTYALSVLAFSVMSFLLLYGIARFQGVLPFNPTDKPAVTDHVAFNAAVSFMTNTNWQSYSGEATMSHFTQMTGLAVQNFVSASAGMCVLAALIRGLARKRASTLGNFWVDLARTVLRIMFPLSFVVAILLVSQGVIQNLHGFIVANTLEGAPQLIPGGPVASQVAIKQLGTNGGGFFNVNSAHPFENYTPIGNFVENWAILIIPFALCFAFGKMVHDRRQGWAVLAIMGIIWIGMSVAAMSFEAKGNPRLDALGVTQQTTVDQSGGNLEGKEVRFGVGASGLWAASTTGTSNGSVNSMHDSYTPLGGMVPLAHMMLGEVSPGGTGVGLNGLLVMAILAVFIAGLMVGRTPEYLGKKIQATEMKLVTLYILAMPIALLSFAAASVLISSALASRNNPGPHGLSEILYAYTSGANNNGSAFAGLTASTWSYDTTIGVAMLIGRFFLIIPVLAIAGSLARKGTTPVTAATFPTHKPLFVGLVIGVVLIVGGLTFFPALALGPIVEQLSTQ
Protein: Fibronectin leucine-rich transmembrane 3 (Leucine-rich repeat transmembrane protein FLRT3 precursor) (B8A507)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L3
- Unc-5 netrin receptor B.
- Fibroblast growth factor 17
- Fibroblast growth factor receptor 1-A
- Fibroblast growth factor 8
- Rho-related GTP-binding protein Rho6
Sequence:
MASNYMSFFVFFIRAGLLLGLANPLMTSASCPSQCRCDGTFIYCNDRDLTSIPSGIPEDATVLFLQNNRIKSAGIPTDLRRLNGVEKIYLYCNNLDEFPTNLPLNVKELHLQENNIRTITHASLAQIPFIEELHLDDNSVSAVSIEEGAFRDSNHLRLLFLSRNHLSTIPSGLPMTIEELRFDDNRISSISEASLQDLINLKRLVLDGNLLNNRGIGEMALVNLVNLTELSLVRNSLTSPPANLPGSSLEKLNLQDNHINHVPPGAFAFLRQLYRLDLSGNNLSSLPMGVFEDLDNLTQLLLRNNPWHCNCRMKWVRDWLRTLPSKVNVRGFMCQGPDKVKGMAIKDLSTELFGCSDTEIPTTYETSTVSNTLPPSRPQWPSYVTKRPVVKGPDLGRNYRSTTPSSRKIITISVKSSSAETVHISWRVSQPMTALRLSWLKLGHSPAFGSITETIVQGERTEYLLTALEPESSYRICMVPMETSNIYLSDETPVCIETETGSLKAYNPTTTLNREQEKEPYKNSNLPLASIIGGAVALLAIIMLALVCWYVHRNGSLFSRNCTYNKGRRRKDDYAEAGTKKDNSILEIRETSFQMIPINHMPVSKEEFVIHTIFPPNGLSLYKSPHSENSINNRSYRDSGIPDSDYSHS
Protein: Protein STICHEL (O64728)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a key regulator of trichome branching through an endoreduplication-independent pathway.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Replication factor C subunit 3
- Replication factor C subunit 5
- Replication factor C subunit 2
- Cell cycle checkpoint protein RAD17
- Proliferating cellular nuclear antigen 1
- Proliferating cell nuclear antigen 2
- Checkpoint protein
- DNA primase
- Replication factor C subunit 1
- Chromosome transmission fidelity protein 18 homolog
Sequence:
MSGSRVSDLSKLHLKKELTQIRKAGRVLRDPGTTSSWKSPLDSSRSVALLETPASRNGGSSSQFPIRGESSTNRRGKEKKVFLYNWKTQKSSSEKSGLAKNGKEEEEEEEDASSWTQASVNDDDDVSDARNGGDSYRREIQSASMGFRCRDTNLASQGVSKMRKSNVGSCKKKSKKKISSSRLDCLSKYQPRDDIVARNCNAGSDDTEEELSNSEDLRKVTGASPLLLKLKQKNWSRSSSRLLRANNRKEDSSCTYNSTPALSTSSYNMYAVRNPSTVGSWDGTTTSVNDGDDELDDNLDLPGRQGCGIPCYWTKKAMKHRGGCRSCCSPSFSDTLRRTGSSILCGSQSVYRRHNRHSSGGYSKQKIACRSAQGVLPLLSYGGDGRGGSSLGTGLSDDELSTNYGELDLEAQSRLDGRRWSTSYRSQDGLEAVALDGEEEEGSTPETIRSFSQKYRPMFFEELIGQSIVVQSLMNAVKRSRIAPVYLFQGPRGTGKTSTARIFSAALNCVATEEMKPCGYCKECNDFMSGKSKDFWELDGANKKGADKVRYLLKNLPTILPRNSSMYKVFVIDECHLLPSKTWLSFLKFLENPLQKVVFIFITTDLENVPRTIQSRCQKFLFDKLKDSDIVVRLKKIASDENLDVDLHALDLIAMNADGSLRDAETMLEQLSLLGKRITTALVNELVGVVSDEKLLELLELALSSDTAETVKRARELLDLGADPIVLMSQLASLIMDIIAGTYKVVDEKYSNAFFDGRNLTEADMEGLKHALKLLSEAEKQLRVSNDRSTWFTATLLQLGSMPSPGTTHTGSSRRQSSRATDDDPASVSREVMAYKQRIGGLHFSKSASPASVIKRNGNHSHEAKPFSRVIDNNCYKSSSSSQMIESEGSIASHENSIASTMMLNQRSSEKLNDIWRKCIERCHSKTLRQLLYTHGKLISISEVEGILVAYIAFGENDIKLRAERFLSSITNSIEMVLRRSVEVRIILLPETELLVVPHQTRKPEMTNKSGHLNNIAGLNAETDVEVGSSVESRSKLPMQRIESIIREQRLETAWLQTADKDTPGSIIRVKPERNQILPQEDTYRQTNVASAISSSGLTTHQWVDELNNEVKLLKIGDNGELQENLTGTRGQHCPLSPSLLHDTNFGNNKDNLGGYESGSGRVGCNILFCWNTKKTQRRSKSKQVKGTPVRSRRNRKSRFSLFNGCAKPRKAEGNIRR