wanglab/gogpt-training-data huggingface dataset:
Protein: Glutamate racemase (EC 5.1.1.3) (P63640)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Provides the (R)-glutamate required for cell wall biosynthesis.
Interaction partners:
Sequence:
MDNRPIGFLDSGVGGLTVVRELMRQLPHEEIVYIGDSARAPYGPRPAEQIREYTWQLVNFLLTKDVKMIVIACNTATAVVWEEIKAQLDIPVLGVILPGASAAIKSSQGGKIGVIGTPMTVQSDIYRQKIHDLDPDLQVESLACPKFAPLVESGALSTSVTKKVVYETLRPLVGKVDSLILGCTHYPLLRPIIQNVMGPKVQLIDSGAECVRDISVLLNYFEINRGRDAGPLHHRFYTTASSQSFAQIGEEWLEKEIHVEHVEL
Protein: Coiled-coil domain-containing protein 102B (Q68D86)
Organism: Homo sapiens (Human)
Function: During interphase, forms fibers at the proximal ends of centrioles to maintain centrosome cohesion. During mitosis, dissociates from the centrosome following phosphorylation to allow centrosome separation. Contributes to CROCC/rootletin filament formation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30404835}. Note=Concentrated at the proximal ends of centrioles where it forms fibers (PubMed:30404835). Centrosomal localization becomes weak when cells enter prophase and is significantly decreased in metaphase (PubMed:30404835). {ECO:0000269|PubMed:30404835}.
Interaction partners:
Sequence:
MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAHSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEAKVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQNW
Protein: RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) (P55199)
Organism: Homo sapiens (Human)
Function: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.
Subcellular location: Nucleus {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:12446457}. Nucleus speckle {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:12446457}. Nucleus, Cajal body {ECO:0000269|PubMed:12686606, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. Note=Colocalizes with EAF2 to nuclear speckles (PubMed:12446457). Colocalizes with coilin in subnuclear cajal and histone locus bodies (PubMed:12686606). Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes (PubMed:23932780). {ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12686606, ECO:0000269|PubMed:23932780}.
Interaction partners:
- ELL-associated factor 1
- AF4/FMR2 family member 1
- Protein AF-9
- AF4/FMR2 family member 4
- Protein ENL
- ELL-associated factor 2
- Cyclin-T1
- Cyclin-dependent kinase 9
- RNA polymerase II elongation factor ELL3
- Little elongation complex subunit 2
Sequence:
MAALKEDRSYGLSCGRVSDGSKVSVFHVKLTDSALRAFESYRARQDSVSLRPSIRFQGSQGHISIPQPDCPAEARTFSFYLSNIGRDNPQGSFDCIQQYVSSHGEVHLDCLGSIQDKITVCATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKVQFRKPAPGATDAVPSRKRATPINLASAIRKSGASAVSGGSGVSQRPFRDRVLHLLALRPYRKAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPNGREALLPTPGPPASTDTLSSSTHLPPRLEPPRAHDPLADVSNDLGHSGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQLRQLSQGSEEYETTRGQILQEYRKIKKTNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQRQLQAWP
Protein: MORF4 family-associated protein 1 (T-cell activation protein-related protein) (Q5M820)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y605}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9Y605}. Note=Colocalizes with MORF4L1 to cell nuclei. {ECO:0000250|UniProtKB:Q9Y605}.
Interaction partners:
- Mortality factor 4-like protein 2
- Mortality factor 4-like protein 1
Sequence:
MRPLDAVELAEPEEVEVLEPEEDFEQFLLPVIHEMREDIASLTRERGRAPVRNRGKLWEMDNMLIQIKTQVEASEESALNHLQGAGGAEPRGPRAEKADEKAQEMAKMAEMLVQLVRRIEKSESS
Protein: ABC transporter B family member 29, chloroplastic (ABC transporter ABCB.29) (AtABCB29) (ABC2 homolog 12) (Q9LZB8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:18431481}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:18431481}.
Interaction partners:
- ABC transporter B family member 24, mitochondrial
- ABC transporter B family member 23, mitochondrial
Sequence:
MSFLLLTPPPCLLIPPPPLSHRRSSSLFLKHPFQPSPRPLSFCKPSALRLRANTTVNSLKALETIKPYLQSESKTVLLGWLCSCVSVVSLSQIVPRLGSFTSNLNANAASLTKLKGECLVLAGLVLAKVVAYYLQQAFLWEAALNTVYKIRVFAYRRVLERELEFFEGGNGISSGDIAYRITAEASEVADTIYALLNTVVPSAIQISVMTAHMIVASPALTLVSAMVIPSVALLIAYLGDRLRKISRKAQIASAQLSTYLNEVLPAILFVKANNAEISESVRFQRFARADLDERFKKKKMKSLIPQIVQVMYLGSLSIFCVGAVILAGSSLSSSAIVSFVASLAFLIDPVQDLGKAYNELKQGEPAIERLFDLTSLESKVIERPEAIQLEKVAGEVELCDISFKYDENMLPVLDGLNLHIKAGETVALVGPSGGGKTTLIKLLLRLYEPSSGSIIIDKIDIKDIKLESLRKHVGLVSQDTTLFSGTIADNIGYRDLTTGIDMKRVELAAKTANADEFIRNLPEGYNTGVGPRGSSLSGGQKQRLAIARALYQKSSILILDEATSALDSLSELLVREALERVMQDHTVIVIAHRLETVMMAQRVFLVERGKLKELNRSSLLSTHKDSLTSAGLVI
Protein: Tubulin alpha-1 chain (EC 3.6.5.-) (P24633)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Tubulin beta-2 chain
- Tubulin beta-1 chain
- Dynein heavy chain, cytoplasmic
- Tubulin alpha-2 chain
- RNase H type-1 domain-containing protein
- Calponin-homology domain protein
- Cytoplasmic dynein intermediate chain
- Mis6 domain protein
- ATP synthase subunit beta
- Actin, gamma
Sequence:
MREVISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKKEDPDHGFSTFFSETGQGKYVPRTIYADLEPNVVDEVRTGTYRSLFHPENLITGKEDASNNYARGHYTVGKEMIDQVLDKVRRMADSCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQNATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPSYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYSPVISADKASHEANSVQDITMSCFEPNNQMVKCDPRNGKYMATCLLYRGDVVPKETHAAVATLKTKRTIQFVDWCPTGFKIGICYQPPQQVPNGDLAKVNRAVCMLSNTTAISEAWSALDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVASDSLEEEGEEVEY
Protein: CRISPR-associated endoribonuclease Cas6 (EC 3.1.-.-) (Q8U1S4)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), also called psiRNA (prokaryotic silencing) in this organism. This protein processes pre-crRNA into individual crRNA units, with an 8-nt 5'-repeat DNA tag that may help other proteins recognize the crRNA. Further processing occurs at their 3' termini in this organism. Generates a 5'-hydroxy and 2',3'-cyclic phosphodiester.
Interaction partners:
- CRISPR-associated endoribonuclease Cas2
- CRISPR system Cmr subunit Cmr6
- CRISPR-associated exonuclease Cas4
- CRISPR-associated endonuclease Cas1
- CRISPR system Cmr subunit Cmr3
- CRISPR system Cmr subunit Cmr2
- CRISPR system Cmr endoribonuclease Cmr4
- CRISPR-associated helicase Cas3
- Type I-B CRISPR-associated protein Cas5
- Ferredoxin
Sequence:
MRFLIRLVPEDKDRAFKVPYNHQYYLQGLIYNAIKSSNPKLATYLHEVKGPKLFTYSLFMAEKREHPKGLPYFLGYKKGFFYFSTCVPEIAEALVNGLLMNPEVRLWDERFYLHEIKVLREPKKFNGSTFVTLSPIAVTVVRKGKSYDVPPMEKEFYSIIKDDLQDKYVMAYGDKPPSEFEMEVLIAKPKRFRIKPGIYQTAWHLVFRAYGNDDLLKVGYEVGFGEKNSLGFGMVKVEGNKTTKEAEEQEKITFNSREELKTGV
Protein: Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) (Q08828)
Organism: Homo sapiens (Human)
Function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P19754}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19754}. Cell membrane {ECO:0000269|PubMed:11549699}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O88444}. Membrane raft {ECO:0000250|UniProtKB:P19754}. Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. {ECO:0000250|UniProtKB:O88444}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Calmodulin-like protein 5
- Calmodulin-like protein 4
- Calmodulin-like protein 6
- Calmodulin-1
- Calmodulin-like protein 3
- cAMP-dependent protein kinase catalytic subunit gamma
- Rap guanine nucleotide exchange factor 3
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
Sequence:
MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAVSGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRAGLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA
Protein: CalG3 (Q8KND7)
Organism: Micromonospora echinospora (Micromonospora purpurea)
Interaction partners:
Sequence:
MLFVSSPGIGHLFPLIQLAWGFRTAGHDVLIAVAEHADRAAAAGLEVVDVAPDYSAVKVFEQVAKDNPRFAETVATRPAIDLEEWGVQIAAVNRPLVDGTMALVDDYRPDLVVYEQGATVGLLAADRAGVPAVQRNQSAWRTRGMHRSIASFLTDLMDKHQVSLPEPVATIESFPPSLLLEAEPEGWFMRWVPYGGGAVLGDRLPPVPARPEVAITMGTIELQAFGIGAVEPIIAAAGEVDADFVLALGDLDISPLGTLPRNVRAVGWTPLHTLLRTCTAVVHHGGGGTVMTAIDAGIPQLLAPDPRDQFQHTAREAVSRRGIGLVSTSDKVDADLLRRLIGDESLRTAAREVREEMVALPTPAETVRRIVERISG
Protein: Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Q8CHD8)
Organism: Mus musculus (Mouse)
Function: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). Also required for the structural integrity of the endosomal recycling compartment during interphase. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity).
Subcellular location: Recycling endosome membrane {ECO:0000250|UniProtKB:O75154}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O75154}. Cleavage furrow {ECO:0000250|UniProtKB:O75154}. Midbody {ECO:0000250|UniProtKB:O75154}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O75154}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:O75154}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- Ras-related protein Rab-11A
- Rab-3A-interacting protein
- Rab11 family-interacting protein 4
- Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
- ADP-ribosylation factor 6
- ADP-ribosylation factor 4
- Rab11 family-interacting protein 2
- Rab11 family-interacting protein 5
- Homeobox protein goosecoid
- Phosphatidylinositol 4-kinase beta
Sequence:
MELCQPTSLSDHDQPASGPQRGVMGLVGPDAPRGWSEEPEEHAQLQRWPEGPNAPICWPEEVEEPHAPSRWAKEPNAPRCSSQEPDESCHLAEELEESDSPRCWPQEPDTPCHLAKELEEPDAPRCLPQEPDTPCYLAKELEEPNIPRCWPQEPDVPCHLAKELEEPDAPRCWPQEPDAFCHLLKEVEEPDALRCWLQGPDAPCHLAKELEDLDSPRCWPQEPDESCHLAKELEEPDAPCHLAKELEEPDAPRCWPQEPDVPCLLAKKWEESDAPCLLTEELEEPDALHCWPQESEAPCLLAKELEEPDASHSCPQEADTGCLSAKEPEEPDVSHLWQGVPDAPCLLVKEPEEADALHCCWPEESEEPDALNPPCFWANEPDEPDPSRCWSEEPQVLCLWPEEQNTKRCWQEEPDAPCFWPEDREEPIVSCLQFKEPEKPKVRSSWPEELEDCCPTRGLPLEPLLADGELLQACPGPPSDPGPALSLPSEPGTAQEEGARLRAVFDALDRDGDGFVRIEDFIQFATVYGAEQVKDLTQYLDPSGLGVISFEDFYQGIVAIRNGDPDGQLYSVEPVQDEETPACADEFDDFVTYEANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDVDSAGGSGVPSECLDTMEEPDHGALLLLPGRSRPHSQAVVMVIGSEEHFEDYGEGNEAELSPETLCDGDGEDPAFLTPSPAKRLSSRKVARYLHQSGTLTMEALEDPPPEPVECPEEDIADKVIFLERRVSELEKDSAAAGEQHGRLRQENLQLVHRANALEEQLKEQEFRAQEKVLEETRKQKELLCKMEREKSIEIENLQARLQQLDEENSELRSCTPCLKANIERLEEEKQKMLDEIEELTQRLSEEQENKRKMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLRLEVEQRRGRSSSLGLQEYNSRARESELEQEVRRLKQDNRNLKEQNDELNGQIITLSIQGAKSLFSTSFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAILETNPSILEVK
Protein: Gb|AAD20086.1 (Nuclear transport factor 2 (NTF2) family protein with RNA binding (RRM-RBD-RNP motifs) domain-containing protein) (Q9FND0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 24
- Polyadenylate-binding protein RBP47A
- Eukaryotic translation initiation factor 2 subunit alpha homolog
- Serine/arginine-rich SC35-like splicing factor SCL30
- Sister chromatid cohesion protein PDS5 homolog C
- NTF2-like protein
- T-complex protein 1 subunit beta
- protein-synthesizing GTPase
- Nuclear transport factor 2A
- Nuclear transport factor 2 family protein
Sequence:
MATPYPGATQVGSYFVGQYYQVLQQQPDLIHQFYSEPSRAIRIDGDSTETANSLLHIHNMVMSLNFTAIEVKTINSVESWEGGVLVVVSGSVKTKEFSNRRSFVQTFFLAPQEKGYFVLSDVFLFVDEGTVYYHQPSYLSEIKHEAQLNPPTRHPDPQVSDYVLEEEASDYVNAVQIKDDLVDKYSLQEDQHQPQHEDYEDEVAIEETPREEVAVDVVHEHRAAPVEEPVGEKSKMSYASILKVAKEAATVPVAATQPSYNKSSQDINEWDQPMRTPSPQLAAPLAPIQQSNSSTYVSDYGAEAEDGSGFEDFEFKSVYVRNLPSDISASEIEEEFKNFGTIKPDGVFLRTRKDVMGVCYAFVEFEDMTSVENAIKASPIYLGGRQVYIEERRPNPAGVRGARRGGGRGRGGYPTEAPRGRFGGRGSGRGNQDGGDYRPRGNGYYRGGGR
Protein: CAX-interacting protein 4 (Q84Y18)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May regulate CAX1 cation transporter.
Subcellular location: Nucleus {ECO:0000269|PubMed:14960315}.
Interaction partners:
- Vacuolar cation/proton exchanger 4
- Vacuolar cation/proton exchanger 1
- Vacuolar cation/proton exchanger 3
- Putative potassium transporter 12
- Vacuolar cation/proton exchanger 2
- Potassium transporter 7
Sequence:
MPATAGRVRMPANNRVHSSAALQTHGIWQSAIGYDPYAPTSKEEPKTTQQKTEDPENSYASFQGLLALARITGSNNDEARGSCKKCGRVGHLTFQCRNFLSTKEDKEKDPGAIEAAVLSGLEKIRRGVGKGEVEEVSSEEEEESESSDSDVDSEMERIIAERFGKKKGGSSVKKTSSVRKKKKRVSDESDSDSDSGDRKRRRRSMKKRSSHKRRSLSESEDEEEGRSKRRKERRGRKRDEDDSDESEDEDDRRVKRKSRKEKRRRRSRRNHSDDSDSESSEDDRRQKRRNKVAASSDSEANVSGDDVSRVGRGSSKRSEKKSRKRHHRKERE
Protein: Iodotyrosine deiodinase (EC 1.21.1.1) (Halotyrosine dehalogenase) (A7S5D9)
Organism: Nematostella vectensis (Starlet sea anemone)
Function: Catalyzes the dehalogenation of halotyrosines such as 3,5-diiodo-L-tyrosine. Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity).
Interaction partners:
- Uncharacterized protein
- ABC transmembrane type-2 domain-containing protein
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Phosphonoacetaldehyde hydrolase
- 2Fe-2S ferredoxin-type domain-containing protein
- 2Fe-2S ferredoxin-type domain-containing protein
- Riboflavin kinase
Sequence:
MEVFKALFKSKEAYTVDVDPMKDSDEHDLPRDPLSIRVTGEEEVNHIPYPYFDEIPTEEEMKKKSAEFYKSMKKRRTVRKISSEPVPLEVIENIVRVAGTSPSGAHTEPWTYVVIRDPDLKKQIKEVVEEEEQLNYARRMGEKWVQDLSILKTTWSKPYIETAPYLILIFKQVYGIKPDGDKKVHYYNEISVCISCGLLLAAIQNAGLVTVTSTPMNAGPRLRVLLNRPQNEKLIMLLPVGYPAKDAEVPNLTRKPLEEIMVLK
Protein: CX3CL1-binding protein 1 (Gametocyte exported protein 10) (PfGEXP10) (Q8I2D9)
Organism: Plasmodium falciparum (isolate 3D7)
Function: By binding to host chemokine CX3CL1, mediates the cytoadherence of host erythrocytes infected with parasite mature forms (late trophozoite and schizont) to endothelial cells, which sequesters them away from the circulation and thus prevents their elimination by the host spleen.
Subcellular location: Host cell membrane {ECO:0000269|PubMed:27653778}; Multi-pass membrane protein {ECO:0000255}. Host cytoplasmic vesicle membrane {ECO:0000269|PubMed:20332084}; Multi-pass membrane protein {ECO:0000255}. Note=At the ring and trophozoite stages, localizes to Maurer's clefts (PubMed:32184257). Localizes to the cell membrane of host erythrocyte infected with parasite mature forms (late trophozoite and schizont) (PubMed:27653778). In gametocytes, localizes to the host erythrocyte cytoplasm; export to the host cytoplasm begins after stage I (PubMed:20332084). {ECO:0000269|PubMed:20332084, ECO:0000269|PubMed:27653778, ECO:0000269|PubMed:32184257}.
Interaction partners:
Sequence:
MNIYIRTIFFAPFICLLIFSSNHGLFQKKDNQNCNSHKFCLNCSGSYLKNSRWLSETSVSYSDEGEPLKYGANDNNYDSNLLKSEEQKQEISEHMKMLIKLYIDSSHDSAKEEKLFQQVKKYFKNNEYKDFMRTFIKVIKIHNDLTHLKKQMASTEKRYRIISCVAAFLSTVSLAFTVVMLSTLNLKNENVIVTIILGLLGFIISLPVISYILSPYLNSSLEKGYRIADLYSEKILRQILHFQ
Protein: T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247) (P24161)
Organism: Mus musculus (Mouse)
Function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).
Subcellular location: Cell membrane {ECO:0000269|PubMed:9575182}; Single-pass type I membrane protein.
Interaction partners:
- T-cell surface glycoprotein CD3 gamma chain
- Tyrosine-protein kinase ZAP-70
- Natural cytotoxicity triggering receptor 1
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface glycoprotein CD3 delta chain
- Tyrosine-protein kinase SYK
- Tumor necrosis factor receptor superfamily member 9
- Tyrosine-protein kinase Fyn
- High affinity immunoglobulin epsilon receptor subunit gamma
- Low affinity immunoglobulin gamma Fc region receptor III
Sequence:
MKWKVSVLACILHVRFPGAEAQSFGLLDPKLCYLLDGILFIYGVIITALYLRAKFSRSAETAANLQDPNQLYNELNLGRREEYDVLEKKRARDPEMGGKQQRRRNPQEGVYNALQKDKMAEAYSEIGTKGERRRGKGHDGLYQGLSTATKDTYDALHMQTLAPR
Protein: MIP05908p (Pcf11 cleavage and polyadenylation factor subunit, isoform C) (C0P8M6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEQLFQNYRDDERRIGEEYLSSLQDLNCNSKPLINMLTMLAEENINYAHIIVKVVEYYISQVNKTKAYLLKNKDTPAYTQLIDGRH
Protein: Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) (Q6IRE4)
Organism: Rattus norvegicus (Rat)
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q99816}. Early endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99816}. Late endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q99816}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q99816}. Nucleus {ECO:0000250|UniProtKB:Q99816}. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis. {ECO:0000250|UniProtKB:Q99816}.
Interaction partners:
- Vacuolar protein sorting-associated protein 28 homolog
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- VPS37B subunit of ESCRT-I
- Programmed cell death 6-interacting protein
- CD63 antigen
- Similar to DNA segment, Chr 8, ERATO Doi 531, expressed, isoform CRA_c.
- Ubiquitin-associated protein 1
- Arrestin domain-containing protein 1
- Multivesicular body subunit 12A
- CD9 antigen
Sequence:
MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYRGNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELIQIMIVIFGEEPPVFSRPTVSASYPPYTAAGPPNTSYLPSMPSGISAYPSGYPPNPSGYPGCPYPPAGPYPATTSSQYPSQPPVTTAGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDGAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY