wanglab/gogpt-training-data huggingface dataset:
Protein: Peroxisomal membrane protein PEX31 (Peroxin-31) (P53203)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Peroxisomal membrane protein PEX30
- Peroxisomal membrane protein PEX29
- Peroxisomal membrane protein PEX28
- Peroxisomal biogenesis factor 3
- Peroxisomal membrane protein PMP27
- Sporulation-specific protein 73
Sequence:
MSEINNENLEPTSSTVAESTESKNKHIRSALRKRRGKLSAQTYEEDQEAILSSPLLTSTPKTVSRSLVRLYPYLIVVDNFLSIITWSNDNVSANLLGIFLFTVCVLYFGFITRYFGHLMIVGIIWVYLLIDKHVQETMASCPSLDDIIHVMDRVSMKSSAVLSPITILSAQDVRRLLFTIAFLSPVYIFLTVFVLSPNYLMLIGGLYVLTYHSKLIRRMRRYLWKFRVVRLLVFFITGLDLGGPDNNRRLFASVNKKIRSFVWNEVGNTSNTKKTVLFKVALFENQRRWLGIGWTSTMLSYERASWTDEFLNTSPSPEVFTLPEEQSGMAWEWHDKDWMLDLTNDGIIQLPASAAKTKVKPGADEGFIYYDNTWNNPSATDTYKKYTRRRRWIRTATVTTTYDDEPTVEKATPNSHALKSEENNRVRKRKVSFSTANEVHIIPSSDSSKLIQISDVSMSPSL
Protein: RNA helicase (EC 3.6.4.13) (O88757)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
KFEKNFYQEHPDLARRTAQEVDTYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSVFAACHCTHKPPAILR
Protein: Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit SOH1) (hSOH1) (Q9Y3C7)
Organism: Homo sapiens (Human)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 26
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 18
Sequence:
MAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNNTSGK
Protein: Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) (P49902)
Organism: Homo sapiens (Human)
Function: Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:9371705}.
Interaction partners:
- Cytosolic 5'-nucleotidase 1A
- Deoxycytidine kinase
- 5'
- Cytosolic 5'-nucleotidase 3A
- 5'
- Purine nucleoside phosphorylase
- Cytosolic 5'-nucleotidase 1B
- Deoxycytidylate deaminase
- Inosine-5'-monophosphate dehydrogenase 2
- 7-methylguanosine phosphate-specific 5'-nucleotidase
Sequence:
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEEE
Protein: Ras homolog gene family, member V (Ras family GTPase) (Ras homolog family member V) (Rho-related GTP-binding protein RhoV) (Q5YLG6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- non-specific serine/threonine protein kinase
- Non-specific serine/threonine protein kinase.
- Intersectin 2a.
- Intersectin-2b
- Intersectin 1
- Non-specific serine/threonine protein kinase.
- non-specific serine/threonine protein kinase
Sequence:
MPPQMDYFYHESRVPSVCLEQDEELLEPAISCMLVGDGAVGKTSMIVSYTTNGYPTDYKQTAFDVFSGQVQVDGTPVRIQLMDTAGQEEFDEFRSLSYAHTDVFLLCFSVVNPTSFQNITKKWIPEIRECNPSSPIILVGTQSDLVLDVNVLIDLDRYKVKPVCSSRARSLSEKIRAAEYVECSALTQKNLKEAFDAAIFAAIKHKARKAKKRRLSDRRTKAFSKCSWKKFFCFI
Protein: Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) (F8VX42)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004137}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004137}; Intermembrane side {ECO:0000256|ARBA:ARBA00004137}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTAPSCAFPVQFRQPSVSGLSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGKNT
Protein: Iodotyrosine deiodinase (EC 1.21.1.1) (Halotyrosine dehalogenase) (Protein condet) (E1JIB2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. Activity towards 3-fluoro-L-tyrosine is weak. Important for male and female fertility. May be involved in maintaining the viability of sperm, both during development in the testes and storage in the female spermatheca.
Subcellular location: Cell membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MDVDELISSSKLLKHWPSLFITLALIWIVKRLFFKGNRVLKTYNLDEQVEEEVEHFADLGDELQPALEDKPHVPFVPGQNLNPNGAKRLYELMRGRRSIRSFNSHPKPDLSVIEDCIRAAGTAPSGAHTEPWTYCVVQEPELKRSIREIVEQEELVNYSQRMHPQWVTDLRPLQTNHVKEYLTEAPYLILIFKQTYGLSENGKRMRRHYYNEISTSIAAGILLCALQAAGLASLVTTPLNCGPALRNLLGRPVNEKLLILLPVGYPKDGCTVPDLARKNLSNIMVTF
Protein: Candida glabrata strain CBS138 chromosome K complete sequence (Q6FMZ0)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Acyl-coenzyme A oxidase
- DASH complex subunit SPC34
- acetyl-CoA C-acyltransferase
- Acetyl-CoA acetyltransferase
Sequence:
MVSQLFEEKAKAVNELPTQPSQDEMLKLYGLYKQATVGDNTKEKPGIFNMKDRYKWDAWEKLKGMSQEEAEQKYIELVDELIAKYN
Protein: LIM homeobox protein (P92031)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MVMAEIGGHLAHQLPLHNHNHNQTGLQPSLVMNHHLDLDCHGHDVIKKQRLSHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCDKCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSLTSSSVESNNNISSSNNNNTNLSNNNHSSELGSMSDSGSESGSHKSIRDKRPSGPSDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMHEEKEGRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQTYQPPWKALSDFALHADLDSNGAINTHTPAFQQLVNQMHGYDLNGMPILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPNQQPGGSSLDSGITSHHHPDSTDSYVTYLESDDKSKLALTPSSSSSASAGTSISSPPSGVGAGGGGAVGGGSGVLGLGVVANQSATEQLMQMLQKVTGSASPASHAVL
Protein: Nicotinate N-methyltransferase 1 (EC 2.1.1.7) (I1M2U5)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Involved in nicotinate detoxification in planta. Catalyzes the conversion of nicotinate to N-methylnicotinate, which is a detoxified form of endogenous nicotinate in planta.
Interaction partners:
Sequence:
MEKEESTEQRKQARLAIMELANMISVPMALNAVVRLNVADAIWQGGANNPLSAAEILPRLLPAGGGDAENLQRLLRMLASYGVFYEHLSAGERKYSLTDVGKTLVTDEQGLSYAHYVLQHHQDALMRAWPMVHEAVVDPTKEPFERANGEPAYGYYLKHPEMNDLMVRAMSGVSVPFIRAMLEGYDGFQGVEKLVDVGGSGGDCLRMILEKHPTIKEGINFDLPEVVAKAPQIPFVTHVGGDMFKFIPQGDAIFMKWVLTTWTDEECKHIMQNCHKALPEGGKLIACEPVLPEDSDESHRTRALLEGDIFVMTIYRAKGKHRTEEQFRQLAIDAGFPRFRAFHVDHFYTVLEFQK
Protein: Phosphatidylinositol-3-phosphatase (A0A1D8PEV5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- 1-phosphatidylinositol 4-kinase
- Phosphatidylinositol 4-kinase PIK1a
- 1-phosphatidylinositol-4-phosphate 5-kinase
- Phosphatidylinositol-3-phosphatase
- Phosphatidylinositol 4-kinase
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
- phosphoinositide 5-phosphatase
- Phosphatidylinositol 3-kinase VPS34
- phosphoinositide 5-phosphatase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Sequence:
MVLTHSTATDGTHIFHNKVSGNYLILTSGGGVEVSQTIPFVYQNLANAKTISCIIGVIRLKFNSYVIIADKHSVTGSILGHDIGFIESFQILPIGINDLAKKNLEELSYLKLLTTHLNNATLYYSIDNKYDVTNSLQRQFNKSNTGGVVPVDDRFWWNKYLTQDLVNNHVGNDFVHPIIYGYFKSHSAVFNGKSLQFALLTRRSTLRAGTRYFRRGIDIDGNVANFNETEQIFISDDNHLFSLLQTRGSVPVYWAEINNLKYKPNLVISSQSSLDATEKHFHQQVFLYGDNYLVNLVNQKGYEKPVKQAYESAVNNLPEKLGQHVNYIYFDFHHECKGMKYHKINLLLDRLISLGYTSNNYFEYDLNANKIIRLQDKIVRTNCMDCLDRTNVVQSTIGRWVLQNQFTETNYLSSNNVTPFEKLNPQFNLFFQNFWADNADAVSCAYSGTGALKTDFTRLGKRTYKGGLNDFLNSVTRYYKNNLTDGSRQDSYDLFLGKYKPFQDSVRSPFIDRRSPYNQLLPYLMGTSFLILLAIIYFPKGSIWNWKNLFIMAFCILFNLKNLSYINSHGYQFVDWPKLINLDFLKKNEIYTNGTTGKIVGIKYEEAENFTVNNKKKN
Protein: RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (CTD phosphatase FCP1) (Q03254)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II.
Subcellular location: Nucleus.
Interaction partners:
- Transcription initiation factor IIF subunit alpha
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB3
- Transcription initiation factor IIB
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- DNA-directed RNA polymerase II subunit RPB2
- Transcription elongation factor SPT5
- Transcription initiation factor IIF subunit beta
- DNA-directed RNA polymerase II subunit RPB4
Sequence:
MTTQIRSPQGLPYPIQIDKLIPSVGSYLHEGDRLLVYKFWYLVERASDTGDDDNEHDVSPGGSAGSNGVSPPTKQLRESIEFFESPYEGDLISWNVDVGDEVATANQVICEIKRPCNHDIVYGGLCTQCGKEVSADAFDGVPLDVVGDVDLQISETEAIRTGKALKEHLRRDKKLILVVDLDQTIIHCGVDPTIAEWKNDPNNPNFETLRDVKSFTLDEELVLPLMYMNDDGSMLRPPPVRKCWYYVKVRPGLKEFFAKVAPLFEMHIYTMATRAYALQIAKIVDPTGELFGDRILSRDENGSLTTKSLAKLFPTDQSMVVVIDDRGDVWNWCPNLIKVVPYNFFVGVGDINSNFLPKQSTGMLQLGRKTRQKSQESQELLTDIMDNEKKLQEKIDKEVKRQEEKLNHQLATAEEPPANESKEELTKKLEYSASLEVQQQNRPLAKLQKHLHDQKLLVDDDDELYYLMGTLSNIHKTYYDMLSQQNEPEPNLMEIIPSLKQKVFQNCYFVFSGLIPLGTDIQRSDIVIWTSTFGATSTPDIDYLTTHLITKNPSTYKARLAKKFNPQIKIVHPDWIFECLVNWKKVDEKPYTLIVDSPISDEELQNFQTQLQKRQEYLEETQEQQHMLTSQENLNLFAAGTSWLNNDDDEDIPDTASDDDEDDDHDDESDDENNSEGIDRKRSIEDNHDDTSQKKTKAEPSQDGPVQHKGEGDDNEDSDSQLEEELMDMLDD
Protein: Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I) (P10620)
Organism: Homo sapiens (Human)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P08011}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P08011}.
Interaction partners:
- Microsomal glutathione S-transferase 2
- Glutathione S-transferase 3, mitochondrial
- Epoxide hydrolase 1
- Glutathione reductase, mitochondrial
- Leukotriene C4 synthase
- Peroxiredoxin-6
- Cytochrome P450 1B1
- Cytochrome P450 2E1
- Cytochrome P450 1A1
- Phospholipid hydroperoxide glutathione peroxidase GPX4
Sequence:
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIAYLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL
Protein: Tumor necrosis factor (TNF-alpha) (Q9I976)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MEGYAMTPEDMERGPVYNTTVTAVAEGKASRGWLWRLCGVLLIAGLCAAAALLFAWCQHGRPSTMQDEIEPQLEILIGAKDTHHTLKQIAGNAKAAIHLEGEYNPNLSADTVQWRKDDGQAFSQGGFELQGNQILIPHTGLFFVYSQASFRVKCNSPGEHTTPLSHIIWRYSDSIGVNANLLSGVRSVCQQNYGDAESEIGEGWYNAVYLGAVFQLNEGDKLWTETNRLTDVEPEQGKNFFGVFAL
Protein: At3g49760 (BZIP transcription factor AtbZip5) (Basic leucine-zipper 5) (Q29PT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Basic leucine-zipper 70
- Activator of spomin::LUC2
Sequence:
MMSTISPVFSTEPGLLTSVLPAFETSFTPWDISHLFSVFDSLIDPKPVSTHDYGSVNQIGSDMSPTDNTDERKKKRKLSNRESAKRSREKKQKHLEEMSIQLNQLKIQNQELKNQLRYVLYHCQRTKMENDRLLMEHRILHDKLLNIRQVLMFRQT
Protein: Elongin-A (P53861)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit RPO21 to trigger its proteolysis; plays a role in global genomic repair.
Interaction partners:
- Elongin-C
- RING-box protein HRT1
- Cullin-3
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL19A
Sequence:
MKSLQTLCEISLMRNHSNIQSVSNVPYHLLKRILQKVKIPQLLKLEKSNVLLIFDDDELWLEFLRQDFPTNVHEQFVSKRDIICKYYFDFVKENDIELYHSNQDLLKSCVRQSVVKDIRNNKYRIPYRMLYSKYQQEVEKKQEESAERLRLEMQKLQQEREKKQTIVVDHTVYFKKRNTKKTTRLHNEPHSQLYMKSLKDHESRLKHFKDGGFNIAKRHAQRVAFGGQAGGQSSSPKKGPLSIKPEPVKVNRQMDNVTAEKKDVTQPITPVKKRRSESPSIFLNRKKPALFRPTPKTNAAGSRPHTTAITNDHRTTSHPYPHKDVVTSISSVTANPVTKGHKKKKSGIFVRNAGSDGDSFPHVTATGPTTRPYIYEPRK
Protein: RNA helicase (EC 3.6.4.13) (A0A2R8Y5G6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNTTSKKHGNNGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN
Protein: Ubiquitin fusion degradation protein 1 homolog (UB fusion protein 1) (Q19584)
Organism: Caenorhabditis elegans
Function: Functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway (By similarity). In association with npl-4.1 and/or npl-4.2 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with npl-4.1 and/or npl-4.2, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5. Regulates ubxn-3 nuclear localization during S phase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18728180}. Nucleus {ECO:0000269|PubMed:18728180}. Note=Localizes to the cytoplasm during mitosis. Nuclear localization upon nuclear membrane re-assembly is cdc-48-dependent. {ECO:0000269|PubMed:18728180}.
Interaction partners:
- Nuclear protein localization protein 4 homolog 1
- Nuclear protein localization protein 4 homolog 2
- Transitional endoplasmic reticulum ATPase homolog 1
- Transitional endoplasmic reticulum ATPase homolog 2
- Ubiquitin fusion degradation protein 3 homolog
- Ubiquitin conjugation factor E4 ufd-2
- Derlin-1
- Derlin-2
- UBX domain-containing protein 2
- UBX domain-containing protein 3
Sequence:
MQAWIQQGLHGMQMGGRVGNYDQTFVVYGPVFLPNATQSKISEINYGGKILLPSSALNLLMQYNIPMPMLFKLTNMAVQRVTHCGVLEFSAPEGQAILPLWMMQQLGLDDGDTIRIESATLPKATFAKLKPMSLEFLNITNPKAVLEVELRKYACLTKNDRIPTSYAGQTLEFLVVDLKPANSVCIIECDVNLDFDPPEGYVEQPRQVTPAVTAKPPAPDASAFIGAGQKAGGSGGTGQNATSVFGGAGRRLDGKKKPSSSVSLSDGTGVSTSNAAPVANDLPAIPPVVVNEDYKPGRVSFLRYDYKRVDVLEKELREKEASKAGQPSNVFRGGNRTLRGAR
Protein: Uncharacterized protein (F4I4N4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transmembrane protein
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- Type II inositol polyphosphate 5-phosphatase 15
- Peroxidase 66
- Defensin-like protein 4
Sequence:
MDPIESVEYNGFETTNGNSHNDDHGWKKVVYPKRNRKQKPADQAAATKNGVTGNLIPNGTLSNGGGNVFRSLEEQAEGRHLQILAAKKASDTADVSDGGRSKWRSNGYGDEGYDFDDSDSEIAVGKENLKAEEVKKPKVKKVKKPKVTLAEAAAKIDVSNLAAFLVEASESYASQPEIQLMKFADYFGRSLSQVSSAHFPWVKTFKESPLSKLIDIPLSHIPEAVYKTSADWINQRPIEALGAFVLWGLDCILADLAVQQGGVKGGKKGAQQASSKSQVAIFVAVAMVLRKKPDALTNILPTLRENPKYQGQDKLPVTVWMMAQASQGDISVGLYSWAHNLLPVVSSKSCNPQSRDLILQLVERILSNPKARTILVNGAVRKGERLIPPPSFEILVRLTFPASSARVKATERFEAIYPLLKEVSLAGAPGSKAMKQVTQQIFTFALKAAGEENPLLAKEAAAITIWALTQNVDCCKHWENLYTDNLKASVAVLKKLIGEWKERSVKLTPAETLTLNQTMKSLRQKNEEALTEGGNGVSQSLYKDADKYCKVIAGKLSSGGCIKSIATTAALLAATGFAGAAALSANPEAIAYLKNLVESLDINKFTETVMTALKN
Protein: ATP synthase subunit e, mitochondrial (Q7LZ14)
Organism: Gallus gallus (Chicken)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273, ECO:0000256|RuleBase:RU367005}.
Interaction partners:
Sequence:
MIPPVQVSPLIKFTXYSALLVGMIYGKKXYDYLKPIA
Protein: Roundabout homolog 4 isoform X1 (Roundabout, axon guidance receptor, homolog 4 (Drosophila)) (F1RE66)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Slit homolog 2
- Slit homolog 1a
- Slit homolog 1b
- Unc-5 netrin receptor B.
- Slit homolog 3
- Netrin-1
Sequence:
MQVSAWMLWVAWLCTCSKAVRQCACPPDEQVAQRSEGKGHLRHRLMHQRASHRDRAHRRKGSRLVSEINLPRIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDTDKMDAQSQPIVLPDGSLFFFSVVPGRKGQSHEAVYACIAHNSIGNATSRNASLHIAALREDFRVQPSDVEVAIGEMATINCSPPVGHPEPNVTWRKDGILINSSNEHYTELKGKLIIAPAQKNDSGVYSCIASNMIGVRESRAARLSVLAKPVLLRKPEDVSVQLGESAQFFCEADGDPMPSIEWSREQGPLPNGRYLINPDHSLQIHYVTAQDMGRYSCTVENKLGVSVASAQLLVEDAGGTRLRDLHKELSALRVSLENVTVMSTASNMSQVMWKLQSFGSQPHYLEGFEVLYRSLLPASSDWTAQRVPQPSLHTHVGPLKRGYKYEFKVRPYGSSLYGRESNTRHLRVPEIVPSAAPQDVSITMPAERNDTVHLSWEPPPHDAHNGIIQGYQVWCVESEEQTSFNWTVDSGTHSIEIFTLLPSRLYWVTVAAVNGAGVGVQSDPYKLLIESRLEATPYQTGILSMSHFVSVIKEPVFIGSVGTLLWCVLMITAVFLYRRHIRPANPSGKSSGLYRLESEDLIIKHRMAAPDSPWISGGWRPGSNSEPKQGLWTPSQENSGLRRTTLPITVKKDPNPLRSAVPIVPDNCGVYGTFYVDLTGNGLKTFNSPGRCPRMPHGNSQLQNSETIRITEPIVKTAVVRELQALPWKRTLPAQPNMGVKKESWEKNVKRELHAVKSAPLMPLNQQALAVCSAPNHQQRFSQHPAGGVSEPVKPLSSPRILHYSASLQLVDMLPSPPPLPMEDNHSLSSEDESTRSTKLTVDIGSQQSVCAASGLQGPASANTGCPNNHSPAQLSPSYSHLSTASFCLSTDDYQDTTLSTQGHTQYMEISPKPQGQSTSHQSTPSMPRPFSPTPTLGYICGPGDREMDEEQETVPIGLRRATLRSTPSSCCSEWEGSLWNGWGSVSESNVTSARTSIISSSDCSFINDANFARVLALTAESMSGNLSDFSPPASPLSVLFPPRECFGEVEPLPVWDWSTAWVEELEAQFKASRDPRRPARNSGIERWRGHLESPSHR
Protein: Papillary renal cell carcinoma isoform 1 (A0A0S2Z456)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLVAYASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPAPKGPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGFPPPPGVSPAEAAGVGEGLGLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDSDSEEDEPTKKKTILQGSSEGTGLSALLPQPKNLTVKETNRLLLPHAFSRKPSDGSPDTKPSRLASKTKTSSLAPVVGTTTTTPSPSAIKAAAKSAALQVTKQITQEEDDSDEEVAPENFFSLPEKAEPPGVEPYPYPIPTVPEELPPGTEPEPAFQDDAANAPLEFKMAAGSSGAPWMPKPGDDYSYNQFSTYGDANAAGAYYQDYYSGGYYPAQDPALVPPQEIAPDASFIDDEAFKRLQGKRNRGREEINFVEIKGDDQLSGAQQWMTKSLTEEKTMKSFSKKKGEQPTGQQRRKHQITYLIHQAKERELELKNTWSENKLSRRQTQAKYGF
Protein: Interleukin enhancer-binding factor 2 homolog (Q9VG73)
Organism: Drosophila melanogaster (Fruit fly)
Function: May regulate transcription of undefined genes.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Zinc-finger protein at 72D, isoform B
- FI21236p1
- Small ribosomal subunit protein uS10m
- Probable small nuclear ribonucleoprotein Sm D2
- Heterogeneous nuclear ribonucleoprotein K, isoform C
- Small nuclear ribonucleoprotein F
- LD24793p
- GH08712p
Sequence:
MVRGALRGGRPMRGGIRPPFKKTFVPRHPFDLTLAEVFFPKVPSAGAVDDSALTAALLKRNQDLSPTPSEQTAIGNLVTKVQAVLDNLVVAPGDLTTCQLEEVRQVGSFKKGTILTGNNVADVVVILKTLPTKEAVDALAKKVEADLKASMKTEVLTKGDQHTVQIHERGFDIANVHAKVRILIATLPQNLRKLEPEIHLDHKLMQSHLAAIRHTRWFEENAHHSSIKVLIRILKDLTRRFDAFSPLSAWMLDLIAHLAIMNNPSRQALPINLAFRRVFQLLSAGLFLPGSAGITDPTEPGHIRVHTAMTLEQQDVCCYTSQTLLRVLAHGGYKHILGLEGNTSVVREMSVWNGVCISPLTAVYEKPTDKKEGDLEEDIDMIENENEEEGSDDGAE
Protein: Aminoacyl-histidine dipeptidase (O51553)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
- Uncharacterized protein
Sequence:
MSIVIDSFKEISKIPRCSKNIKGIINFIKQRAKKFGYSFKEDRVGNIVVQIKSNNNIDMHPIILQSHVDMVCEKNESSLHNFETDPIEIVEEDGYLKAVGTTLGADNGIGVAMMLGIMSEANNFPHPDLELLFTVDEEIGLIGALGLDSNLCSGKSLINLDGEEEGYFLVGCAGSRLVEIVFSPKYSLVTKKTKVEILFKGLKGGHSGADIHLDLANSLKLMFFALFEIKANLNFEIEGIFGGNSSNAIPIEAKALIFIDDNDYDLLNKELKLFVLKVKSAYSLEDEFDIIVNKREFSSVKVLDENSKNKLLNMGMGFLHGVQKVENYENKLIKTSLNFSSLLRMQDDYIFTFLIRSLLDLDKEYVCNHLQSISDLSGANLRVIYDDPSWQPDKNSNLLKHLQEVYKEMYLEDANVSTIHAGLETGIISSRLGGIESVTLGPWIEWPHTTRERVNISSTIRVYDFLKKSLERFQKF
Protein: Large ribosomal subunit protein uL14c (50S ribosomal protein L14, chloroplastic) (P0C438)
Organism: Oryza sativa (Rice)
Function: Binds to 23S rRNA.
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MIQPQTLLNVADNSGARKLMCIRVIGAASNQRYARIGDVIVAVIKDAVPQMPLERSEVIRAVIVRTCKEFKCEDGIIIRYDDNAAVIIDQKGNPKGTRVFGAIAEELRELNFTKIVSLAPEVL
Protein: Interferon alpha and beta receptor subunit 1 (D3ZDS9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Tyrosine-protein kinase
- Interferon alpha/beta receptor 2
- Tyrosine-protein kinase
- Interferon beta
- Signal transducer and activator of transcription
- Interferon epsilon
- Interferon gamma receptor 1
- Interferon 1fa
- Interferon gamma
- Interferon gamma receptor 2
Sequence:
MLAVVGAAALVLVAGAPWMLPVASGEDNLRPPEDVAIYIIDDNYTLKWNHHRESMGNVTFSAEYQKGEGRIWLKVPKCQHITRTKCEFSLLGINVYSKTQFRVRAEEGNSTSSWNEADSFIPFYKAHVSPPRVHLKAEDKAILVYISPPGEDGTMWAQEKRCFNYTIRIWGRSFPVREIKPMYFPKKISKLLPETTYCLEVRAVHTSLQRHSNYSSARCINTTVANKIPVPENLEVDVQGDSYVLKWDHAFANMTFKAQWIPVYSKSSPGNHSDKWKPIPTCANVQTTHCVSPRETFHTGTFFLRVQASDGNNTSFWSEEKLIDSQKYTLLPPPVIAVTPTGDSLLVYVSCKDSKCNGLIYEVIFWENTSNTEKRQHPQSMIKEHPEFNVVNLRPLTVYCVQARVLSTGVWNKTSKFSDKLCKKTHPGNSSVTWIITGFGALLFSAMAFYAGRSLQKYLYYVFSPPLKPPCSIDEFFSELPSKSLLLLTAEEHTERCFVIENTGVVAGEENRAPEEELRKYSSQSSQDSGNYSNEEEESVGPESGQDMLSTAPSGSPWSLPCPAGTLEDGACFPGKEKHLQSPVLRTQPALHG
Protein: ABC transmembrane type-1 domain-containing protein (Q8BIU4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEINVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHRKPIDLRAIGKLPIAMRALTNYQRLCAAFDAQARKDTQSQQGARAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPSTDHCGRDPPLLHPWGQCLDWSSCHHSAGSCTVLCGHQALPGTAEHPGIFQ