wanglab/gogpt-training-data huggingface dataset:
Protein: Epididymal-specific lipocalin-5 (Epididymal retinoic acid-binding protein) (E-RABP) (mE-RABP) (Epididymal secretory protein 10) (MEP 10) [Cleaved into: Epididymal-specific lipocalin-5, major form; Epididymal-specific lipocalin-5, minor form] (A2AJB7)
Organism: Mus musculus (Mouse)
Function: Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 13-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation.
Subcellular location: Secreted {ECO:0000269|PubMed:1591332, ECO:0000269|PubMed:2393684}. Note=Synthesized by the mid and distal caput of the epididymis and secreted into the epididymal lumen. {ECO:0000269|PubMed:1591332, ECO:0000269|PubMed:2393684}.
Interaction partners:
- Epididymal-specific lipocalin-9
- Epididymal secretory glutathione peroxidase
Sequence:
MCSVARHMESIMLFTLLGLCVGLAAGTEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDLTCVNALQSGQI
Protein: Kinesin heavy chain 73, isoform F (EC 3.6.1.3) (A0A0B4LGK5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLPLIEPFSEDEFDDKDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQPKSKTEFATDNQNGNRSSDELSHSSEDLLEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRINHRASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVLPEWIVVGESVLIRPYNTSGVIRFVGTTEFQPGAWIGVELDTPTGKNDGSVKGVQYFQCKPKHGMFVRSDKLMLDKRGKAMRAYKAAEKSNSISKEMSTSMTGSMTRSKSRGDSLNLSARK
Protein: Proline/serine-rich coiled-coil protein 1 (Q6PGN9)
Organism: Homo sapiens (Human)
Function: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.
Interaction partners:
- Cadherin EGF LAG seven-pass G-type receptor 2
- Sortilin
- Proprotein convertase subtilisin/kexin type 9
- Myosin-binding protein H-like
Sequence:
MEDLEEDVRFIVDETLDFGGLSPSDSREEEDITVLVTPEKPLRRGLSHRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEANRLAAQLEQCALQDRESAGEGLGPRRVKPSPRRETFVLKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSGKRPSNMKRESPTCNLFPASKSPASSPLTRSTPPVRGRAGPSGRAAASEETRAAKLRVSGSGEFVGLTLKFLHPSPPGPPTPIRSVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLTSRSVPPGRGALPPDSLSTRKGLPRPSTAGHRVRESGHKVPVSQRLNLPVMGATRSNLQPPRKVAVPGPTR
Protein: HN (B9VJ59)
Organism: Mumps orthorubulavirus (MuV)
Subcellular location: Host cell membrane {ECO:0000256|ARBA:ARBA00004336}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004336}. Virion membrane {ECO:0000256|ARBA:ARBA00004208}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004208}.
Interaction partners:
Sequence:
MEPSKLFTISDNATFAPGPVINAADKKTFRTCFRILVLSVQAVTLILVIVTLGELVRMINDQGLSNQLPSITNKIRESATMIASAVGVMNQVIHGVTISLPLQIEGNQNQLLSTLATICTSKKQVSNCSTNIPLVNDLRFINGINKFIIEDYATHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQYVSMGILVQTASRYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYVSTQLETDDYAGSSPPTQKLTLLFYNDTVTERTISPSGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSTLGVKSAREFFRPVNPYNPCSGPQQDLDQRALRSYFPSYFSNRRVQSAFLVCAWNQILVTNCELVVPSSNQTLMGAEGRVLLINNRLLYYQRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGSGSCSGENVCPTACVSGVYLDPWPLTPYSHQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLTVLAPYGTQGLFASYTTTTCFQDTGDASVYCVYIMELASNIVGEFQILPVLTRLTIT
Protein: Lebercilin (Leber congenital amaurosis 5 protein) (Q86VQ0)
Organism: Homo sapiens (Human)
Function: Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17546029}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:17546029}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17546029}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17546029}. Cell projection, cilium {ECO:0000269|PubMed:21606596}. Note=In non- ciliated cells, localizes to the centrosome and its associated microtubule array (PubMed:17546029). Colocalizes with IFT complex A and B proteins in the connecting cilium in primary cilia of hTERT-RPE1 cells (PubMed:21606596). {ECO:0000269|PubMed:17546029, ECO:0000269|PubMed:21606596}.
Interaction partners:
- Ninein-like protein
- Usherin
- X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
- Spermatogenesis-associated protein 7
- Protein RD3
- Trafficking protein particle complex subunit 5
- Retinal guanylyl cyclase 1
- Centriole and centriolar satellite protein OFD1
- Aryl-hydrocarbon-interacting protein-like 1
- Retinol dehydrogenase 12
Sequence:
MGERAGSPGTDQERKAGKHHYSYLSDFETPQSSGRSSLVSSSPASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSGNVRSPASPNEFAFGSYVPSFAKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITRKEKKANLMEQLFGASGSSTISSKSSDPNSVASSKGDIDPLNFLPGNKGSRDQEHDEDEGFFLSEGRSFNPNRHRLKHADDKPAVKAADSVEDEIEEVALR
Protein: Ethylene-responsive transcription factor ERF011 (Q9SNE1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MDAGVAVKADVAVKMKRERPFKGIRMRKWGKWVAEIREPNKRSRLWLGSYSTPEAAARAYDTAVFYLRGPTATLNFPELLPCTSAEDMSAATIRKKATEVGAQVDAIGATVVQNNKRRRVFSQKRDFGGGLLELVDLNKLPDPENLDDDLVGK
Protein: Nuclear transport factor 2 (NTF2) family protein (Q9FMC7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDPARECEGKGACELKSNKRFADKIMPHLLNLYGSSAKANDFDMYAPNASFEDPLTHAQGVKQIKSAFYSLPKVFGESKIVEYHIQESETSPGKKEILIDNKQHYKIMGRNIDMISLIKLYVEDGKIVRHEDWWDKKPLRNRDTVSFPLVGRVMEMGRRGLMLATHAMMGFGKDPDSQ
Protein: Beta-toxin Ct25 (P0DUI3)
Organism: Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Function: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
Subcellular location: Secreted {ECO:0000269|PubMed:23840487}.
Interaction partners:
Sequence:
MKVLILIIASVLLIGVECKDGYPKNSEGCKISCVIGNTFCDTECKMLKASSGYCWTLGLACYCEGLPENVEVWDSATNKCGGK
Protein: Coagulation factor V (F5 protein) (B7ZVT7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKLRSWPGALHGLALLAFLCHCATAVERHYYIAAVNINWDYTSGQQRTGQSYKKVVYREYNEGFKQPKAHPLSSGLLGPTLRGQEGDTIIVTFRNMADHPCSLHPHGIAYGKQSEGSLYFDNTSLLEKNDDVIQPGEEHTYQWDVTSDVTPTAADPPCITYTYLSHFDIVRDYNTGLIGPMLICKKGTLDDSGNQIHFHQESVLLFGVFDENKSWYSTGDSPQPLNVKYTINGYTNGSVPDLDICAHSKVSWHLLGMSSEPELFSVHFNGQVLLHDGHKTSAVGIISGTATSASMTGVHPGRWLVSSHISKHLEAGLHGYLNIRKCDEYTAPKRRLTIEQKKESQEWTYYMAAEEVIWDYAPNMPENMDGDFRSKYLKQGPQRIGKKYKKAVFTQYKDGMFKERAEDKQRKRELGILGPVIRAQIRDIIKIVFKNKASRPYSIYPHGLTIDKAAEGASYPQGGNQTYSVQPGETYTYTWSVTEEDVPTDSDPRCLTRMYHSAVDAPRDIASGLVGPLLICKSQSLNKKNVQLKADKEQHAMFTVFDENKSWYQDENINTYCSDPKKVKKDDPEFYKSNVMHTINGYVYESGQELGFCHGEIVTWHVSSVGEQDYIQTATFYGHTFELKNREEDILSLFPMTGETITMNMVNIGIWLLASLNSHDSTKGMRVKFKDLECFRDYVIEYDYEDGKFTAWKPPTINEIKKEEPVRARPDVVDEYSDLFAETLNLRTFNNVKDEVEIIDLTFLDQDDGLLPIVEEKSLGSSNENLHNATLQSFIETHGLLMEEGDLDKGESSNKVLNDSTDKALLETTTTFDSNRVVALNNETDSIILDFPIVERKVRSAPSKPMNEPESVTMNFKTTEHINSSLERINAIYSPITETNINTMTETHTDFSITPFDGSTGEMNFTLEDDTALLNSSESEPLQSNQNSENRIAFQEELNAKDGTDVDSNNSVKNQIFKYNVPSGDTLSNSSKIQVEEDFVLLDSSYFSEMSTTMEYDVSQKDTVKGESKETAQSQELSSTKKTYSGEIILESLPDITSAFNLNSSSVLRNNSLESNESSNETLFMSSNATFSDSTNATSSDSSTATFADFSNTTFSNATFSDFSNRISQMSDSSNATLSDSSNATLSDSSNATLSDSSNATLSDSSNATLSNSSNATFSDSSNKTFSDSSNATLFGVSYSSNTTLSDFSLESEMTEYILSSANDTIKSHSEVVSNTSQLSSSESTENISLLYGSLNASSMKNDSESESEEEVVIYLNKNHSEAILTSHLDQKEEHWGYESKHELVHKELPDHMNKYVKDKSAANSNKPKIEKEKKKVYQRVKPKKGYGMKTKKSKDYKPQPRSSFSPRGFGPSVLTPRGSRPVSSEDELTEKPIVIGVPRRDFNDYELYIPKQDQEADFDGLLDHPEEYEYVEYKDPYSKTADVQALDATSQHLLKMAGDKNTRTYFISVEEEEWDYAGYGQRRLDKTAQNERPTVFRKVVFRRYLDSTFSIRDIRGEMDEHLGILGPLIKAEVDQTVMVFFRNRASRPYSLHANGVKYLKQMEGLSYDDESPYWYKQDDAVPPNGTFTYMWTINPKSGPQNNESDCRTWTYYSAVNPERDINSGLIGPLLVCRKGTLDKKPEDRREFVLLFMTFDENKSWLYEENRQRIERKNRRVVMDPNFQDNLKFDAINGIIYSLKGLRMYTNQLAKWHLINMGSPKDLHSVHFHGQTFINKELKDHRQGVYPLLPGGFATLEMLPSKPGLWQLESEVGLSQQRGMQTLFLVLDNVCDHPLGLISGTVQDEQITASDTRGQWYPHLARLHNTGKYNAWSTSSEPGQYLQVDFQRPVVISKVATQGAKQFLTHNFVLNYTISYSTDKKKWIYYKGDSDAVRKTFEGNAEAYETKENIFFPPLIGRYVRLHPLHSYNFPTVRLEYYGCELDGCSVPLGMEKGLIDDSKITASSVASNWYSGQWHPWYARLNKQGTANAWQAKNNDIQPWIQVELKEVKKITGIVTQGAKSMGNEMFVRSYILEYSEDGRRWMKYTDDDDYEQKLFQGNTDNNGQIKNYIYPPIFSRFIRIIPKQWQKSVTMRIELLGCDFE
Protein: FI04419p (Lamp1) (Q9V9S0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004530}. Membrane {ECO:0000256|PROSITE-ProRule:PRU00740}; Single-pass type I membrane protein {ECO:0000256|PROSITE-ProRule:PRU00740}.
Interaction partners:
- Ras-related protein Rab5
- Raptor, isoform B
- GATOR complex protein NPRL2
- Serine/threonine-protein kinase mTor
- GATOR2 complex protein Wdr24
- Protein SEC13 homolog
- GATOR complex protein NPRL3
- GATOR complex protein Iml1
- GATOR2 complex protein Wdr59
- GATOR2 complex protein Mio
Sequence:
MFANKLLTCSALLIMLFLLSSTVFSQKLIGLPRVGKNVSDLFLEQANPLTSSSSTISTSSTTTEKPITTRSTSTITPRSTTPSTESPSTTAPVISTTIAPQPYPQPSIGAWNTSCIMLQMAAQLNFTYEAREGNFTTGLYNIPSNASVEDAECKSQTTQFIHLIWGPETSKQSLIMYFNKSNDTTVLSFMQIHLALLPEDFPDAKENQTVQLITRSDGAFKTPENMSYHCTRVQKINMTETLDAEQLIGWISVSHVQVEAFRRANDTGFSVGHDCDSSETSDVVPIAVGIALAALILVVLISYLCARRRSTSRGYMSF
Protein: Endo-beta-1,6-galactanase (EC 3.2.1.164) (Q76FP5)
Organism: Hypocrea rufa (Trichoderma viride)
Function: Hydrolyzes galactooligomers with a degree of polymerization higher than 3. Hydrolyzes radish root arabinogalactan-protein. Does not hydrolyze dextran, arabinan, starch, laminarin, beta-1,4- and beta-1,3-galactans, larch wood arabinogalactan or acid-insoluble polygalacturonic acid.
Interaction partners:
Sequence:
MRSIVLPSLALALFSQRARADTTLTIDPTSNWGTWEGWGVSLAWWAKAFGNRDDLASVFFSRNNQAVNGQTLPGLGFNIVRYNAGACSNNSYDGSTMVVSPNIKPSRQMDGFWLDWASSDPSSSSWNWNVDANQRAMLQKAKANGANIFELFSNSPMWWMCNNHNPSGSGSSDNLQSWNYQNHAVYLADIAQHAQQSWRIQFQSVEAFNEPSSSWWTAEGTQEGCHFDVSTMATVIGYLNTELSSRGLSSFVASSDENTYDLAISTWQGFNSSTRNIVKRINVHGYQDGGGRRDTLYSLASQAGKRLWNSEYGDSDASGKSMYQNLLLDFTWLHPTAWVYWQAIDGAGWGLIVGDNDNLTLSSASTKYFVLAQLTRHIRQGMQILTTPDVNTAVAYDAGSQKLVIVTANWGSAQTITFDLTRARTAGSNGATVPRWSTQTGGGDQYRSYTDTKINNGKFSASFSSGQVQTFEVSGVVLQ
Protein: MADS-box transcription factor 47 (MADS-domain-containing protein 1) (OsMDP1) (OsMADS47) (Q5K4R0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor that modulates expressions of multiple genes involved in cell signaling and gene transcription. Plays a negative regulatory role in brassinosteroid signaling.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MAGGGGGGGRGEGEGRAATGKRERIAIRRIDNLAARQVTFSKRRRGLFKKAEELSILCDAEVGLVVFSATGKLFQFASTSMEQIIDRYNSHSKTLQRAEPSQLDLQGEDSSTCARLKEELAETSLRLRQMRGEELHRLNVEQLQELEKSLESGLGSVLKTKSKKILDEIDGLERKRMQLIEENLRLKEQLQVSRMSRMEEMQPGPDSEIVYEEGQSSESVTNASYPRPPPDNDYSSDTSLRLGLSLFSSK
Protein: ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) (Q3UPW2)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity). Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity (By similarity). Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway (By similarity). May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P78545}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:16516205}.
Interaction partners:
- Protein kinase C iota type
Sequence:
MAATCEISNVFSNYFNAMYSSEDPTLAPAPPTTFGTEDLVLTLNNQQMTLEGPGPQTRSQRDRTDPLAVLHLAEKASWTSERPQFWSKTQVLEWISYQVEKNKYDASSIDFSRCDMDGATLCSCALEELRLVFGPLGDQLHAQLRDLTSNSSDELSWIIELLEKDGMSFQESLGDSGPFDQGSPFAQELLDDGRQASPYYCSTYGPGAPSPGSSDVSTARTATPQSSHASDSGGSDVDLDLTESKVFPRDGFPDYKKGEPKHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLWEFIRDILIHPELNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNSSGWKEEEVGESRN
Protein: Transcription factor Sp7 (Zinc finger protein osterix) (Q8TDD2)
Organism: Homo sapiens (Human)
Function: Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8VI67}.
Interaction partners:
- Runt-related transcription factor 2
- Nuclear factor of activated T-cells, cytoplasmic 1
- Ribosomal oxygenase 1
- Osteocalcin
- Integrin-binding sialoprotein
- Collagen alpha-1
- Bone morphogenetic protein 2
- Homeobox protein DLX-5
- Sclerostin
- Catenin beta-1
Sequence:
MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQLEGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPGGSPEQSNLLEI
Protein: Protein BRICK1 (Q54X65)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in regulation of actin and microtubule organization.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Nck-associated protein 1 homolog
- Protein pirA
- Protein SCAR
- Abl interactor homolog
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 3
- Rho-related protein rac1A
Sequence:
MSTKTNIQKDWEQREFIEDMSINIQKIVEFLNKFELSTRNKLSDLNEKLTILDRQVDYLEATFKTVQE
Protein: Zinc finger A20 and AN1 domain-containing stress-associated protein 10 (AtSAP10) (Q9STJ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in environmental stress response.
Interaction partners:
- Zinc finger AN1 and C2H2 domain-containing stress-associated protein 13
- Probable acyl-activating enzyme 8
- Zinc finger AN1 domain-containing stress-associated protein 12
- Protein LIFEGUARD 4
- DNA ligase
- At3g13310
- Immune-associated nucleotide-binding protein 1
- Uncharacterized protein At2g23090
- Pathogenesis-related thaumatin superfamily protein
- Peroxiredoxin-2D
Sequence:
MVNETEALPCEGGCGLYGTRVNNNLCSLCYKKSVLQHSPALRFEPETEQSQCCPPTNSPAVEEEPVKKRRCGICKRKVGMLGFKCRCGHMFCGSHRYPEEHSCPFDYKQSGRLALATQLPLIRADKLQRF
Protein: SH2 domain-containing protein (Q95XA9)
Organism: Caenorhabditis elegans
Interaction partners:
- Rho-GAP domain-containing protein
- Ras protein let-60
- Ras GTPase-activating protein gap-1
- Ras GTPase-activating protein gap-2
- Cell death abnormality protein 2
- Receptor tyrosine-protein kinase let-23
- Sex muscle abnormal protein 5
- KAP NTPase domain-containing protein
- Paxillin homolog 1
- PUM-HD domain-containing protein
Sequence:
MHSSENTTPNSSTEGPLFLKTHTNPTPPDISPNDVWYHGELNEHDANHLLQGTSPGAFLVRQTGQTRFYLSILDQDGYPKHLPIRQLTPPHYFFEGKRFETLRDIVDAYQLAVIPVRKGGIMPINGEIQETKYLCVRRFEQREIDEMNSEIGDILSVCETDETGWMLGRNETSGSVGIILRSHLEPLITEVADLSDLPYFYDTVSTDMVQYSPIGTFLLRRSSKGTDTYALLVKTQFDLVEKFLIVGCPSRGFSLAGRPFPTIGHVLTRYCDRAISGGVRLTHAVCVKHQRKSSSRRSTAEVRWPPFIGNETASMSSSQYDDGLREQKPRRMFRGTSIDTALASSSSFLTSSTAMPSPSTTVSTGIPEHLIDRFHDEDVNNHPETSSSTTTVAATVALRKSREEKQWKECWLTLSDIPGGSSQLSVFDSMGSKLRQQVDLSTCTLFWLDESVFCADGCLFLSPSFPQQQPPTLYLCFRPYTAFLKWIRILRSRTIYQDVPPPMLQGTISVGEPNSQVSILSIEIDKFRSELLKSDMFYSAQVSLNGVKIGVSNAFAPAGNKGPNEMPVVVIDSKFVIPCIPTCSTNIQLSMNSHSSIGKRGRPCGVTVTICLNENNESICQSQADSTGFVFRAQRNRCPVLPLDRYKPLLDMIRECPSSILSWPSQVLPSHLKQFMYTCISHLYALNPQFMSQVIRRIINDILVTSTAEDVFRKDSLATGIITQCLRHLFKTPFDEFLLENAQFSQSLKQQNLDSGGGAVELLVNFVDQRLLTIPLATRLLTIAAECAGCRFGDEQHEQHLIKRTLSALLILRVLNPIIFSTLNTGIGSQIAKLVQISANSAASQTPTDSLTPAASTIRRMFDRIIFLVNQQQPAESPEDSEIGEVHTEWISCLTYMIGHSLTIRSATSSEDVHLPLPVLELIRLHHL
Protein: Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) [Cleaved into: Ferritin heavy chain, N-terminally processed] (P09528)
Organism: Mus musculus (Mouse)
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25327288}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:25327288}. Autolysosome {ECO:0000269|PubMed:25327288}.
Interaction partners:
- Ferritin light chain 1
- Nuclear receptor coactivator 4
- Transferrin receptor protein 1
- T-cell immunoglobulin and mucin domain-containing protein 2
- Cyclic AMP-responsive element-binding protein 1
- Scavenger receptor class A member 5
- Ferroportin
- Natural resistance-associated macrophage protein 2
- Phospholipid hydroperoxide glutathione peroxidase GPX4
- Iron-responsive element-binding protein 2
Sequence:
MTTASPSQVRQNYHQDAEAAINRQINLELYASYVYLSMSCYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWESGLNAMECALHLEKSVNQSLLELHKLATDKNDPHLCDFIETYYLSEQVKSIKELGDHVTNLRKMGAPEAGMAEYLFDKHTLGHGDES
Protein: Artemin (Q9Z0L2)
Organism: Mus musculus (Mouse)
Function: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.
Subcellular location: Secreted {ECO:0000269|PubMed:15204970}.
Interaction partners:
- GDNF family receptor alpha-3
- GDNF family receptor alpha-1
- Proto-oncogene tyrosine-protein kinase receptor Ret
- GDNF family receptor alpha-2
- GDNF family receptor alpha-4
- Syndecan-3
- Glial cell line-derived neurotrophic factor
- Beta-nerve growth factor
- Neurturin
- Persephin
Sequence:
MELGLAEPTALSHCLRPRWQSAWWPTLAVLALLSCVTEASLDPMSRSPAARDGPSPVLAPPTDHLPGGHTAHLCSERTLRPPPQSPQPAPPPPGPALQSPPAALRGARAARAGTRSSRARTTDARGCRLRSQLVPVSALGLGHSSDELIRFRFCSGSCRRARSQHDLSLASLLGAGALRSPPGSRPISQPCCRPTRYEAVSFMDVNSTWRTVDHLSATACGCLG
Protein: Protein-lysine N-methyltransferase EFM5 (EC 2.1.1.-) (Elongation factor methyltransferase 5) (N(6)-adenine-specific DNA methyltransferase-like 1) (P53200)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-79'. Required for replication of Brome mosaic virus (BMV).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03187, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein-lysine N-methyltransferase EFM4
- Protein-lysine N-methyltransferase EFM6
- Protein N-terminal and lysine N-methyltransferase EFM7
- Elongation factor 1-alpha
- Protein-lysine N-methyltransferase EFM1
- Protein-lysine N-methyltransferase EFM3
- Superkiller protein 7
- Protein-lysine N-methyltransferase EFM2
- Adenosine 5'-monophosphoramidase HNT1
Sequence:
MSDSDSDSDYELTLSANALAALEEFKREEQQHQEAFQKLYDETDEDFQKKKKEEGMKLFKEDWQLSQFWYSDDTAAILADAILEGADENTVIAIVSAPSVYAAIQKKPTNEIPTEHIYLFEFDKRFELLAGRDHFFFYDYNKPLDFSDEIKGKVDRLLIDPPFLNEDCQTKSSITAKCLLAPNDNSKTKKGVFKHRLISCTGERMSEVISKVYSDTRITTFLPEHSNGLSNEFRCYANFECSSWKFAS