wanglab/gogpt-training-data huggingface dataset:
Protein: TGN-related, localized SYP41 interacting protein (F4I9A1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MHEKDDLPQDSIADGIENDDESNGQEEEELDPDQGTAFVDSKEDMFVDAPEELNFDTPSKEALTTDDDDNDDLGTHFNIEKGDWEKELAGLQEQFKLLTGENDLTGEDGNTTVDIVSRFSKFLKTAKEERIQHEVALKELHGVISGRDDEIADLTTKISELSSSQPVSEMGDQAQNLEHLEAATDRIMVSLSNVFGEGELQYGSSISEKLAHLENRVSFLGAKYTEFYYGADQLRKCLASDVLDLSFQEDFGSALGAACSELFELKQKEAAFFERLSHLEDENRNFVEQVNREKEMCESMRTEFEKLKAELELEKTKCTNTKEKLSMAVTKGKALVQNRDALKHQLSEKTTELANRLTELQEKEIALESSEVMKGQLEQSLTEKTDELEKCYAELNDRSVSLEAYELTKKELEQSLAEKTKELEECLTKLQEMSTALDQSELDKGELAKSDAMVASYQEMLSVRNSIIENIETILSNIYTPEEGHSFDIVEKVRSLAEERKELTNVSQEYNRLKDLIVSIDLPEEMSQSSLESRLAWLRESFLQGKDEVNALQNRIESVSMSLSAEMEEKSNIRKELDDLSFSLKKMEETAERGSLEREEIVRRLVETSGLMTEGVEDHTSSDINLLVDRSFDKIEKQIRDSSDSSYGNEEIFEAFQSLLYVRDLEFSLCKEMLGEGELISFQVSNLSDELKIASQELAFVKEEKIALEKDLERSEEKSALLRDKLSMAIKKGKGLVQDREKFKTQLDEKKSEIEKLMLELQQLGGTVDGYKNQIDMLSRDLERTKELETELVATKEERDQLQQSLSLIDTLLQKVMKSVEIIALPVDLASEDPSEKIDRLAGYIQEVQLARVEEQEEIEKVKSEVDALTSKLAETQTALKLVEDALSTAEDNISRLTEENRNVQAAKENAELELQKAVADASSVASELDEVLATKSTLEAALMQAERNISDIISEKEEAQGRTATAEMEQEMLQKEASIQKNKLTEAHSTINSLEETLAQTESNMDSLSKQIEDDKVLTTSLKNELEKLKIEAEFERNKMAEASLTIVSHEEALMKAENSLSALQGEMVKAEGEISTLSSKLNVCMEELAGSSGNSQSKSLEIITHLDNLQMLLKDGGLISKVNEFLQRKFKSLRDVDVIARDITRNIGENGLLAGEMGNAEVTAVLLITLLYFQDDSTEAKSLLSDLDNSVNTEPENSQGSAADEDEISSSLRKMAEGVRLRNKTLENNFEGFSTSIDTLIATLMQNMTAARADVLNIVGHNSSLEEQVRSVENIVREQENTISALQKDLSSLISACGAAARELQLEVKNNLLELVQFQENENGGEMESTEDPQELHVSECAQRIKELSSAAEKACATLKLFETTNNAAATVIRDMENRLTEASVALEKAVLERDLNQTKVSSSEAKVESLEELCQDLKLQVKEEKWHEKEVELSTLYDKLLVQEQGNFYLLLSLISLNLHHIITTILKCHVLLLRIAEAKENLIPASDMRTLFDKINGIEVPSVDLVNGLDPQSPYDVKKLFAIVDSVTEMQHQIDILSYGQKELNSTLAEKDLEIQGLKKATEAESTTELELVKAKNELSKLISGLEKLLGILASNNPVVDPNFSESWTLVQALEKKITSLLLESESSKSRAQELGLKLAGSEKLVDKLSLRVKEFEEKLQTKAIQPDIVQERSIFETPRAPSTSEISEIEDKGALGIKSISPVPTAAQVRTVRKGSTDHLSINIDSESEHLMNNNETDEDKGHVFKSLNMSGLIPTQGKIIADRVDGIWVSGGRVLMSRPQARLGVMVYSLLLHLWLLASIL
Protein: ScfA (C8VS78)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MVETRAEGLRQPQSPHFPRVSRACQRCRRQKLKCDEARPCTMCVRAGVSCQSRDIMNTPIRRKKRAVRPPAAATSSNQHVEAAVDRPYEGQNYGASSSAVGFAVNIFGQRATLYSSDISGIPGRASPQPNPRPEWTLEKMSMPPPAVMDAALQAYFDHMHWFIFIFHEIEFMQSVTPLLRQSSWSESSRGRVIAALTAAAVGLQCVAHDSRWPGHSLLASFSLQATSLRDSLIAEVRLHVLKLLDECSLESVQVSLLLGTYYVFHGSPGLAWNMLGLSVRTAYALSMHCPGGITHPDPVLSQVYRRTWNFIIVADTYSAMIYGRPASLDAAFCHLHEMTELEDTRLPPTVSYLLQDPNANGLMFHNQKYRLYEIMRTTLNKVRLINLQTPVSLESFASLVAAIGNAQASLDTWKSGVSPVFKQQYWEEHPALASTAIEKNPPSSENRTIRHLFLQSQMLQLTYDSAVLFINRPLLEHQAKPEFRTAVAEHLSAVRLSMDLSLKAALRVSRVSPVHHESEFSLSFVLMNFFIAGVILCLAPTLWPFSTASNDAKAGVLRIIHASRNLQTKSKIAKHTVQLLTRLVKLSLHQELENALNSNESGSDTNPREQEQGPSQHASPSHSPRLPPTEPCSSSTFKGHFNPPPANPTQSQPAVDVSFPMAGVPAGDLYIEPMHEGGNLNPGLGIPDNSCYHQIDSYMDETLGAFGEMLFNLVPNDPYSAWNWGNNFR
Protein: CLAVATA3/ESR (CLE)-related protein 14 [Cleaved into: CLE14p] (Q3ECJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Acts as an elicitor of the root meristem differentiation through the CLV2/CRN complex signaling pathway. Inhibits irreversibly root growth by reducing cell division rates in the root apical meristem. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular location: [CLE14p]: Secreted, extracellular space {ECO:0000250|UniProtKB:O49519}.
Interaction partners:
- CLAVATA3/ESR
- CLAVATA3/ESR
- Receptor-like protein CLAVATA2
- Leucine-rich repeat receptor-like protein kinase PEPR2
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- Protein CLAVATA 3
- CLAVATA3/ESR
- Probable manganese-transporting ATPase PDR2
Sequence:
MKVWSQRLSFLIVMIFILAGLHSSSAGRKLPSMTTTEEFQRLSFDGKRILSEVTADKKYDRIYGASARLVPKGPNPLHNK
Protein: Cell cycle progression protein 1 (Q640L3)
Organism: Mus musculus (Mouse)
Function: Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation.
Subcellular location: Cytoplasmic granule membrane {ECO:0000269|PubMed:17000758}; Single-pass type II membrane protein {ECO:0000269|PubMed:17000758}.
Interaction partners:
- RB1-inducible coiled-coil protein 1
- Translocation protein SEC62
- Reticulophagy regulator 1
- Gamma-aminobutyric acid receptor-associated protein
- Testis-expressed protein 264 homolog
- Reticulon-3
- Atlastin-3
Sequence:
MSESSSDSDSSCGWTVINHEGSDIEIVNSATASDNCGLTLECSLVEQEELPVLYVGHGGEESSANNTSSVGETMLSSMRETKSAAEVEEAPSPEDNVYFGTTSDDSDIVTLEPPKLEEMGNQEVTIQEAPSSDDLNMGSSSSSQYAFCQPEPVFSSQPSDEESSSDDTSHEPSPAPRRRRNRKKTVSISESEEPPLAEPEDEPSKEPSKRHFSRGLNKCVILALVIAVSMGFGHFYGTIQIQKQLVRKTHEDELDGVKGYLSQRKQEQESFLDFKSLKENLERCWTVTESEKITFETQKKNLAAENQYLRISLEKEEQALSSLQEELRQLREQIRLLEDKGTSTQLVRENQVLKQYLEVEKQKTDSFLREREMLLEEARMLKRDLEREQLTAMALRAELEQFIPGQAQSRAESPSVQTEEKEVGLLQQRLAELEQKLIFEQQRSDLWERLYVEAKDQHGKQETDGRKRGSRGSHRAKSKSKETFLGTVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGSKRFRAPKEAATEKTRTAYSYSSYSQQEAPNQNQNCRRPSAQRDGGREKPSHSEEIRKNANSYTYKAKSDCRGTHSTRRVCSGMFECAGQEAISPVNKASPVRMNDFKQLIHWYLLNELETFHHWKELDQFISPFFPNGVFRHDQQLFADFVDDVKGYLKSIKEYRVEDGNLEKLDGCIYRHFGHVFALPFGPRSVYIKPCYYNSF
Protein: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.7) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) (LYS5 ortholog) (Q9NRN7)
Organism: Homo sapiens (Human)
Function: Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12815048}.
Interaction partners:
- Fatty acid synthase
- Beta-alanine-activating enzyme
- Bifunctional coenzyme A synthase
- Histone acetyltransferase type B catalytic subunit
- Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
- Complex I assembly factor TMEM126B, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Transmembrane protein 126A
- Histone H4
- Histone H4-like protein type G
Sequence:
MVFPAKRFCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHFVAVALRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLMSSAVPMTPEDPSFWDCFCFTEEIPIRNGTKS
Protein: Calpain-A (EC 3.4.22.-) (Calcium-activated neutral proteinase A) (CANP A) [Cleaved into: Calpain-A catalytic subunit] (Q11002)
Organism: Drosophila melanogaster (Fruit fly)
Function: Calcium-regulated non-lysosomal thiol-protease. Involved in the organization of the actin-related cytoskeleton during embryogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7823949}.
Interaction partners:
Sequence:
MDDLRGFLRQAGQEFLNAAGEAAMGAAKDVVGSVINEIFIKKEADTKRVLPSIKNMRVLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTIYS
Protein: ALK and LTK ligand 2a (Augmentor alpha-1) (AUG-alpha-1) (E7F5F0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK. Required for neural crest cell differentiation and iridophore development during embryonic iridophore development and adult stripe development by acting as a receptor for LTK.
Subcellular location: Secreted {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q6UX46}.
Interaction partners:
- Tyrosine-protein kinase receptor
- ALK tyrosine kinase receptor
- Small RNA 2'-O-methyltransferase
Sequence:
MRALRAPVLVMGLVLLICTAAQSDASANKVEKTLRRIMEIMRQVENSADDESAQKTESAPEPKDTHHLKTASGETILEIFPRDLSRKEKFITILTGRRLSNPLRHQSCVFETSDLVVFHPSGPLYFGPKCKKDVYRLYHNTRDCTIPAHYKRCARLLTRLAGTRKCQEG
Protein: Alhambra, isoform I (E1JJ75)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMMMDTMDTSQSQPMDVAPAVAVAATSGAALVDFTAAMVSMAATAEAESAESNNNHIDMAEYKEHRKNKKKKREKREREGKEHRHHKHRDREHREHRRHRDRDRDKERDREGHHHHPTHHHPNNSQHSTSASSSPSSASTTPSATIEYVGGSASASPSYLGGGATGTGAAVGATTTYPHNLKIRFLLSGQRTELSPPTHQTSATAEVNAPLASSTSASIAVTASATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSNIKDISSSSNQQASTASSSSAPSLYVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGPPMGGSAGAFHGGTTSAGSSSVIQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTESGNLKISYEKQTTRVQQLQEQEAPPARRSRTLDLSTASASSSSPSAVPATTSPLVVLSNQLPLNSVAASSSTGGLKFTYESQTQMDVPMMPVSAIKDSPPSSPGSEIGSAMHSATTAPGSLTGASTAATAQPGNVRKRGRKAKDATIAAAAAAAAAAAALSNSQQDLKDVRILQNGASNTPGNPAGSTPTPPATPASSNAVSSASSIITHTAAHMLGNQINPNSSVAQKLSEQLHMEVQDHSIYTPDSMNSQYAGVPFPGKQRNSTAVPSNATPAQNPLQSMFSGGGMNGNMPIPQSLEQLLERQWEQGSQFLMEQAQHFDIASLLNCLHQLQSENLRLEEHVTSLIARRDHLLAVNARLQIPLSTIASNTKAEAHAAISTTAAPTTTTTTSTTTATSTCTTSVISTIASSGNSSTSTIGLGSSTSALNAATTIAAAVSLATTAINTTIPTMANSRPTVAAASSSGVLDYRGPGATSNSSNSNSSNNTISNSVSNSSSNPTSSSSASVPPASSMSISGMSISNATNLGMRHVSAAHGSNNAGNSNSSVWSLTASSTVNSNSLHHQHSSQQQQQHQAQHQSHPLQQQQQQQQQVQHHLHQSHHTSAAVAAAHMLGVGMSLGAGGGAAGGIGRGGSATAMAATAATTTTTFTTTAGTGMGQQHHHPHPHQHPSIQIQSQLRRDDNLAKTS
Protein: Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] (Q58501)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP-GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1-P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcNAc and pyrophosphate. Also catalyzes the reverse reaction, i.e. the cleavage of UDP-GlcNAc with pyrophosphate to form UTP and GlcNAc-1-P. To a lesser extent, is also able to use dUTP or dTTP as the nucleotide substrate, but not CTP, ATP or GTP.
Interaction partners:
- Phosphoglucosamine mutase
- Ribose 1,5-bisphosphate isomerase
- Translation initiation factor 2 subunit alpha
- Translation initiation factor 2 subunit gamma
- Uncharacterized protein MJ0325
- Selenocysteine-specific elongation factor
- Adenosylcobinamide-phosphate guanylyltransferase
- Uncharacterized protein MJ1066
- Putative UDP-glucose 4-epimerase
- Phosphoglycerate kinase
Sequence:
MDAIILCAGKGERLRPLTENRPKPMIPIAGKPILQHIIEKVEDLVDNIYLIVKYKKEKIVDYFKNHPKIKFLEQGEIDGTGQAVLTAKDYVDDEFLVINGDIIFEDDLEEFLKYKYAVAVKEVKNPENFGVVVLDDENNIIELQEKPENPKSNLINAGIYKFDKKIFELIEKTKISERGERELTDAIKHLIKEEKVKGIKLNGYWNDVGRPWDILEANKYLLDKINTDIKGKIEENVVIKGEVIIEEGAIVKANSVIEGPAIIKKGAVVGPLAYIRPYTVLMENTFVGNSSEVKASIIMKNTKIPHLSYVGDSIIGENCNFGCNTITANLRFDDKPVKVNIKSKRVESVRKLGVIMGDNVKTGIQVSFMPGVKVGSNCWIGASCLIDRDIESNTFVYKRDELIFRKLK
Protein: Protein trichome birefringence-like 35 (Q8RXQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Protein REDUCED WALL ACETYLATION 2
- Cellulose synthase-like protein B1
- At5g54130
- Uncharacterized calcium-binding protein At1g02270
- Protein REDUCED WALL ACETYLATION 3
- Putative pumilio homolog 7, chloroplastic
- UDP-glucuronate:xylan alpha-glucuronosyltransferase 1
Sequence:
MSQRWSRKKSRLPLAGLLFILVVTFMILFNERSIQQIHHHAASHTQNLREPSTFDFVKPNVPRINYLGAHEVLDRFSKCNSTKEYSGKKIGWVDPFEDHPGQVTKEEQKCDVFSGKWVFDNSSSYPLHKESQCPYMSDQLACQKHGRKDLEYQHWRWQPHACNLKRWNAIEMWEKLRGKRLMFVGDSLNRGQWISMVCLLQSVIPRDKQSMSPNAHLTIFRAEDYNATVEFLWAPLLVESNSDDPVNHRLSERIIRPDSVLKHASKWQHADILIFNTYLWWRQDSVKLRWSSEEKGSCEEVKSAEGMEMAMDSWGDWVANNVDPNKKRVFFVTMSPTHQWSREWNPGSEGNCYGEKKPIEEESYWGSGSDIPTMRMVKRVLERLGPKVSVINITQLSEYRKDGHPSVYRKFWEPLNEDRLKNPASYSDCTHWCVPGVPDVWNQLLFHFL
Protein: PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) (Q9PW72)
Organism: Gallus gallus (Chicken)
Function: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P36202}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P36202}. Early endosome membrane {ECO:0000250|UniProtKB:P36202}; Peripheral membrane protein {ECO:0000250|UniProtKB:P36202}; Cytoplasmic side {ECO:0000250|UniProtKB:P36202}. Recycling endosome membrane {ECO:0000250|UniProtKB:P36202}; Peripheral membrane protein {ECO:0000250|UniProtKB:P36202}; Cytoplasmic side {ECO:0000250|UniProtKB:P36202}. Nucleus {ECO:0000250|UniProtKB:P50479}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P50479}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P50479}. Synapse, synaptosome {ECO:0000250|UniProtKB:P36202}. Note=Localizes to actin stress fibers in nonmuscle cells. Colocalizes with GRIA1 in early endosomes. Enriched in numerous but not all spine-like structures along dendritic branches. Colocalizes with actin and enriched at sites containing larger amounts of actin and alpha-actinin. Targeted efficiently to spines via its PDZ domain-mediated interaction with the alpha-actinin/actin cytoskeletal complex. Localizes to synaptosomes in brain (By similarity). Colocalizes with F-actin. Colocalizes with TRIP6 at cell-cell contacts and lamellipodia. In the cytoplasm, displays a fibrillar pattern with characteristic thick fibers and occasional clusters. Colocalizes with the actin stress fibers. Oxidative stress induces redistribution from cytoskeleton to cytosol. Colocalizes with SRC at the perinuclear region, but not at focal adhesions (By similarity). {ECO:0000250|UniProtKB:P36202, ECO:0000250|UniProtKB:P50479}.
Interaction partners:
- Tetraspanin
Sequence:
MPHSVALRGPSPWGFRLVGGKDFSTPLTISRINPGSKAALANLCPGDIILAINGESTEAMTHLEAQNKIKACVEQLLLSVSRAEERSWSPPILEDGKAQAYRINIEPEPQDNGPAVGKRPMPHAAGGSPVDSRPALSLQHPQPSRPHASSSADAALPLQLSGLHISPSQSTDPLKSLPRNRNGIDVESDVYKMLQDYERPASEPKQSGSFRYLQGMLEAGENGEKLDRLSNPRSIKPAGPKLGAAMSGLQMLPECTRCGNGIVGTIVKARDKLYHPECFMCDDCGLNLKQRGYFFIEEQLYCETHAKERVKPPEGYDVVAVYPNAKVELV
Protein: S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (SAND) (EC 4.2.-.-) (Radical S-adenosyl methionine domain-containing protein 2) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) (Viperin) (Q8CBB9)
Organism: Mus musculus (Mouse)
Function: Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses (By similarity). Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8WXG1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8WXG1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8WXG1}. Golgi apparatus {ECO:0000250|UniProtKB:Q8WXG1}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8WXG1}. Lipid droplet {ECO:0000269|PubMed:19920176, ECO:0000269|PubMed:21435586}. Mitochondrion {ECO:0000250|UniProtKB:Q8WXG1}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8WXG1}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8WXG1}.
Interaction partners:
- Farnesyl pyrophosphate synthase
- Interferon-induced protein 44
- Antiviral innate immune response effector IFIT1
- Ubiquitin-like protein ISG15
- UMP-CMP kinase 2, mitochondrial
- Geranylgeranyl pyrophosphate synthase
- Ubl carboxyl-terminal hydrolase 18
- 2'-5'-oligoadenylate synthase-like protein 2
- Interferon-induced protein with tetratricopeptide repeats 3
- Interferon-induced helicase C domain-containing protein 1
Sequence:
MGMLVPTALAARLLSLFQQQLGSLWSGLAILFCWLRIALGWLDPGKEQPQVRGEPEDTQETQEDGNSTQPTTPVSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKQAGLEKINFSGGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGSLIRERWFKDYGEYLDILAISCDSFDEQVNALIGRGQGKKNHVENLQKLRRWCRDYKVAFKINSVINRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLISNEEFETFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCTGGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYVWSKADLKLDW
Protein: AT13643p (Q8T470)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTRSHATSTTSSAAASRAEQQPAVSTHDHNYLGNVNSSRAPRRILSRHQRNADELDTSLDVLENSRLLSAIANHRRPTSTTNSNSASNVVTRRLRGRASQANSHDEDHEEEEAAASDEGTDGGSSSQSYEDEDEDSDSEDNQPLTSYVSPSNGRPRRKAKTSSSSATTQERPLRRTRRPPSNNSIANDNDDDDDYVVPRSRRANRGGNQRAGRNQKRPRYNEQSEEEEAAAGYSHRSKRIRNGDSHASSQERSQASTERDQEE
Protein: RE48347p (Rab-related protein 3) (Rab19, isoform A) (Rab19, isoform B) (O18339)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046278}; Lipid-anchor {ECO:0000256|ARBA:ARBA00046278}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00046278}.
Interaction partners:
- Trafficking protein particle complex subunit
- Rab GDP dissociation inhibitor
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 5
- Autophagy-related 16, isoform F
- Related to the N terminus of tre oncogene, isoform A
- Trafficking protein particle complex subunit
- FI18195p1
- Rab11
- Probable trafficking protein particle complex subunit 2
Sequence:
MTARNPQTLMALPNEEHFDFLFKIVLIGDCGTGKTCIVDRFKTGNYIERHGNTIGVDFSMKTIAVEGKQIKLQIWDTAGQERFRTITQSYYRSANGVLIVYDITKRSSFSNLQKWIEEVRRYTASNVLIILVGNKCDLEEQREVDFEEARQMCQYIPEILFVMETSAKENMNVEDAFRCLANELKRQHDANNVEEVPENTITLGQGKPLKSCSSSCNLT
Protein: Sialidase-4 (EC 3.2.1.18) (N-acetyl-alpha-neuraminidase 4) (Q8WWR8)
Organism: Homo sapiens (Human)
Function: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:21521691}; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Mitochondrion membrane {ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:19797320}; Peripheral membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8BZL1}. Note=Predominantly associates with endoplasmic reticulum membranes. Only a small fraction associates with mitochondrial and plasma membranes. {ECO:0000269|PubMed:19797320, ECO:0000269|PubMed:21521691}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion inner membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Mitochondrion outer membrane {ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:19797320}; Peripheral membrane protein. Lysosome lumen {ECO:0000269|PubMed:15213228}. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.
Interaction partners:
- Galactosylceramide sulfotransferase
- Arylsulfatase A
- 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
- Galactocerebrosidase
- Alpha-galactosidase A
- Galactose-3-O-sulfotransferase 2
- Thymidylate kinase
- Beta-galactosidase
- Lysosomal protective protein
- Sialidase-1
Sequence:
MGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGTLAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYRVDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCNARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGPGSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSWTLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYSDLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGCCWPS
Protein: Heat shock cognate 70 kDa protein (HSP70) (P08108)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPCNTVFDAKRLIGRRFDDGVVQSDMKHWPFEVINDSTRPKLQVEYKGETKSFYPEEISSMVLVKMKEIAEAYLGKTVNNAVVTVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKYKKDISDNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKSLRDAKMDKAQVHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGIMNVSAADKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKCEDDVQRDKVSSKNSLESYAFNMKSTVEDEKLQGKISDEDKTKILEKCNEVIGWLDKNQTAEKEEYEHHQKELEKVCNPIITKLYQGAGGMPGGMPEGMAGGFPGAGGAAPGGGGSSGPTIEEVD