wanglab/gogpt-training-data huggingface dataset:
Protein: Voltage-dependent T-type calcium channel subunit alpha (Q5SUG0)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
Interaction partners:
Sequence:
MDEEEDGAGAEESGQPRSFTQLNDLSGAGGRQGPGSTEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLEPYYQTENEDESPFICSQPRENGMRSCRSVPTLRGEGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAVGVRAGLLSSPVARGGQEPQPSGSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRVPRASPEIQDRDANGSRWLMLPPPSTPTPSGGPPRGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPEMLKDKALVEVAPSPGPPTLTSFNIPPGPFSSMHKLLETQSTGACHSSCKISSPCSKADSGACGPDSCPYCARTGAGEPESADHEMPDSDSEAVYEFTQDAQHSDLRDPHRRRRPSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEIGKREDTSGQLSCIQLPVNSQGGDATKSESEPDFFSPSVDGDGDRKKRLALVALGEHSELRKSLLPPLIIHTAATPMSLPKSSSTGVGEALGSGSRRTSSSGSAEPGTAHHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEDRASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRSSASEHQDCNGKSASGRLARTLRADDPPLDGDDGDDEGNLSKGERLRAWVRARLPACCRERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLKRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGVNSPDSPKPGAPHTTAHIGAASSGFSLEHPTMVPHTEEGPVPLGPDLLTVRKSGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGLPKAQSGSILSVHSQPADTSCILQLPKDAHYLLQPHGAPTWGAIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSSFWGGSSIQVQQRSGSQSKVSKHIRLPAPCPGLEPSWAKDPQETRSSLELDTELSWISGDLLPSSQEEPLSPRDLKKCYSVEAQSCRRRPGSWLDEQRRHSIAVSCLDSGSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGPRPPCSPGVCLRRRAPASDSKDPSASSPLDSTAASPSPKKDALSLSGLSSDPTDLDP
Protein: LIM and cysteine-rich domains protein 1 (Q8VEE1)
Organism: Mus musculus (Mouse)
Function: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16199866}. Nucleus {ECO:0000269|PubMed:16199866}. Note=May shuttle between the cytoplasm and the nucleus.
Interaction partners:
- Transcription factor GATA-6
Sequence:
MAKVAKDLNPGVQKMSLGQQQSARGVACLRCKGMCSGFEPHSWRKICKSCKCSQEEHCLSSDLDDDRKIGRLLMDSKYATLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKERQPVTGTEGALYRRRQLMHQLPIYDQDPSRCRGLVENELKAMEEFVKHYKSEALGVGEVALPGQGGLPKEENKTQEKPEGTETTAPTTNGSLGDPSKEVEYVCELCKGAAPVDSPVVYADRAGYSKQWHPTCFQCIKCSEPLVDLIYFWKDGAPWCGRHYCESVRPRCSGCDEIIFSEDYQRVEDLAWHRKHFICEGCEQLLSGRAYIVTKGQLLCPTCSKSKRS
Protein: Zinc finger protein AZF3 (Zinc-finger protein 3) (Q9SSW0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor probably involved in abiotic stress responses. Binds DNA in a sequence-specific manner and can repress the transactivation activity of other transcription factors.
Subcellular location: Nucleus {ECO:0000269|PubMed:15333755, ECO:0000269|PubMed:21852415}.
Interaction partners:
- C2H2 and C2HC zinc fingers superfamily protein
- Zinc finger protein ENHYDROUS
- Zinc finger protein MAGPIE
- C2H2-type zinc finger family protein
- Protein indeterminate-domain 13
Sequence:
MALEALNSPRLVEDPLRFNGVEQWTKCKKRSKRSRSDLHHNHRLTEEEYLAFCLMLLARDGGDLDSVTVAEKPSYKCGVCYKTFSSYQALGGHKASHRSLYGGGENDKSTPSTAVKSHVCSVCGKSFATGQALGGHKRCHYDGGVSNSEGVGSTSHVSSSSHRGFDLNIIPVQGFSPDDEVMSPMATKKPRLK
Protein: Uncharacterized protein (Q57ZR8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- TOG domain-containing protein
- Cytochrome c
Sequence:
MSVSFLLGWQLFILSFQQFLLTEYIYIYIFHVLLCIYIWHKEESTKKKKRRERERKRERKRKEKKRSKGGMTQSQSQGHPRVGPAPLCIDYPTQQPLCPEFTYTTDIIALMAPPRIAAKFSPCFRKYSWDPYAVLLTDHDLERVKKSYRRATAPPAIASSPTRQPPQQNPADMDINDSHHNHNIDHSPSRLPQLCQQQQQQQEQQQQEQQEQEQSLQQQHQQLKLQQQQQQEQQQLKQQSLQQQQQQQHQQQQQRLKRQSLQQHQHYHQHHHRRYHPYAQLHHGGGHQSRGVHHPSWHNRQPVTWRAMGPNQDSEFKSAGGRSAARGSSARFSR
Protein: Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) (P11412)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).
Interaction partners:
- 6-phosphogluconate dehydrogenase, decarboxylating 1
- 6-phosphogluconolactonase-like protein 1
- 6-phosphogluconolactonase 3
- 6-phosphogluconolactonase-like protein 2
- Glucose-6-phosphate isomerase
- 6-phosphogluconate dehydrogenase, decarboxylating 2
- 6-phosphogluconolactonase 4
- Glucokinase-1
- N-acetylglucosamine kinase
- Transketolase 1
Sequence:
MSEGPVKFEKNTVISVFGASGDLAKKKTFPALFGLFREGYLDPSTKIFGYARSKLSMEEDLKSRVLPHLKKPHGEADDSKVEQFFKMVSYISGNYDTDEGFDELRTQIEKFEKSANVDVPHRLFYLALPPSVFLTVAKQIKSRVYAENGITRVIVEKPFGHDLASARELQKNLGPLFKEEELYRIDHYLGKELVKNLLVLRFGNQFLNASWNRDNIQSVQISFKERFGTEGRGGYFDSIGIIRDVMQNHLLQIMTLLTMERPVSFDPESIRDEKVKVLKAVAPIDTDDVLLGQYGKSEDGSKPAYVDDDTVDKDSKCVTFAAMTFNIENERWEGVPIMMRAGKALNESKVEIRLQYKAVASGVFKDIPNNELVIRVQPDAAVYLKFNAKTPGLSNATQVTDLNLTYASRYQDFWIPEAYEVLIRDALLGDHSNFVRDDELDISWGIFTPLLKHIERPDGPTPEIYPYGSRGPKGLKEYMQKHKYVMPEKHPYAWPVTKPEDTKDN
Protein: ATPase 3, plasma membrane-type (EC 7.1.2.1) (Proton pump 3) (P20431)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Subcellular location: Cell membrane {ECO:0000305|PubMed:15308754}; Multi-pass membrane protein {ECO:0000305|PubMed:15308754}.
Interaction partners:
- Soluble inorganic pyrophosphatase 5
- Soluble inorganic pyrophosphatase 4
- Soluble inorganic pyrophosphatase 3
- Soluble inorganic pyrophosphatase 6, chloroplastic
- Soluble inorganic pyrophosphatase 1
- Solute carrier family 35 protein
- Soluble inorganic pyrophosphatase 2
Sequence:
MASGLEDIVNENVDLEKIPIEEVFQQLKCSREGLSGAEGENRLQIFGPNKLEEKKESKLLKFLGFMWNPLSWVMEAAAIMAIALANGGGKPPDWQDFVGIVCLLVINSTISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQVGHFQKVLTAIGNFCICSIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLIEVYCKGVEKDEVLLFAARASRVENQDAIDAAMVGMLADPKEARAGIREIHFLPFNPVDKRTALTFIDSNGNWHRVSKGAPEQILDLCNARADLRKRVHSTIDKYAERGLRSLAVSRQTVPEKTKESSGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSNMYPSSSLLGKHKDEAMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMLIALIWKFDFSPFMVLIIAILNDGTIMTISKDRVKPSPTPDSWKLKEIFATGVVLGGYMAIMTVVFFWAAYKTDFFPRTFHVRDLRGSEHEMMSALYLQVSIVSQALIFVTRSRSWSFTERPGYFLLIAFWVAQLIATAIAVYGNWEFARIKGIGWGWAGVIWLYSIVFYFPLDIMKFAIRYILAGTAWKNIIDNRTAFTTKQNYGIEEREAQWAHAQRTLHGLQNTETANVVPERGGYRELSEIANQAKRRAEIARLRELHTLKGHVESVVKLKGLDIETAGHYTV
Protein: Neutral sphingomyelinase (N-SMase) activation-associated factor (Protein FAN isoform X1) (F1QZ06)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Tumor necrosis factor receptor superfamily, member 1a.
- Sphingomyelin phosphodiesterase 2
Sequence:
MAFITKKDRSKERFSLLLLDLEEQYFEQHIAYNLTNRGPETNRRTNGSLKICSKSVIFEPDDAVKPILKIPLKDCSEIAAVEETAHNPFIESKPACIVIKTKQIYQIKEENVVAPYKYDRGEKKITFQLGSPIKTEDVVQILLQLHRASRLDKQSDQTAMIAAILQSRLARTRFDKNSFQNVTELPHMECEAEMVSPLVTNAGHVCITDCNLYFQPLNSYPDSVVQIGLHSVRRIYKRRHGLRPLGLEVFCTENDLCSDIYLKFYKTKDRDELYYYIATFLENHVAEHTAESYMLQWQRGHISNYQYLLHLNNLADRSVNDLSQYPVFPWVISDYSSTQLDLLNPASFRDLSKPIGALNKERLERLLERYRDMPEPRFMYGSHYSSPGYVLFYLVRVAPEHMLCLQNGRFDHADRMFNSIGETWKNCLEGGTDFKELIPEFYGSDSSFLRNLLGLDLGRRQGGGRVENVELPPWASDPDDFLQKMCLALESQYVSEHLHEWIDLIFGYKQRGSEAVASHNVFHPLTYEGGVDCDSIEDPDQKIAMLTQILEFGQTPRQLFVTPHPQRITPRFYNLSTTPSLSSSELSPVSPCMESFEDLTEESRKMAWSNMNKLVLQSCHKIHKEAVTGVAVTLSGDSIFTTSQDSTLKMFSKENGLQRSVSFSNMALSSCLMLPDDKIVVCSSWDNNVYFYSIAYGRRQDTLMGHDDAVSDICWRDDKLYTASWDSTVKVWECVAADISSNKRTQFDPLAEFEHEAGVNTLDLSPAGTLLATGTKEGTLTVWDLASPLPVNQLTCHSGKIHQVAFSPDSRHILSVGEDSCLMVTDVQTGMLIATIPAEQEQRCFCWDGNTVLSGGISGDLSVWNLLNSKVVHKIPAAHSGAVTCMWMNEQCSSIITGGLDKQIILWKPQY
Protein: Response regulator inhibitor for tor operon (Tor inhibitor) (Q2EES9)
Organism: Escherichia coli (strain K12)
Function: Transcription inhibitory protein for the torCAD operon. Also acts as an excisionase and plays an essential role in the defective prophage CPS53 excision.
Interaction partners:
- TorCAD operon transcriptional regulatory protein TorR
- Prophage integrase IntS
Sequence:
MQHELQPDSLVDLKFIMADTGFGKTFIYDRIKSGDLPKAKVIHGRARWLYRDHCEFKNKLLSRANG
Protein: Zinc finger protein STP4 (Q07351)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Mitochondrion {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized vacuolar protein YLR297W
Sequence:
MLVSSSFASSIDSVMSHETMSLRRNPPFIDTPEKMPNPTASPNGTIHHLIDPSLPLLSSTTSSSRSTLSSTLNSPPPPPLTTSYSSYNSSACQSITSSPTDNTALAHNSKCYFPHSLSPTPLSSNSSSHVILPPISSFTNLITVAEREFNGRSNSLHANFTSPVPRTVLDHHRHELTFCNPNNTTGFKTITPSPPTQHQSILPTAVDNVPRSKSVSSLPVSGFPPLIVKQQQQQQLNSSSSASALPSIHSPLTNEHTSRYSSSLKDSAKITKQRKKKECPICHNFYANLSTHKSTHLTPEDRPHKCPICQRGFARNNDLIRHKKRHWKDEFMQIYARESDNNSGADDQDDTARTSANNDSDDSNDKLAASSSSEETKLLKKNQLKSLYKIKGAFKCPYNSTLINLDMEVYPHKSRSLYFEPINCHQTGVFSRCDTFKNHLKALHFEYPPKTKKEDRGVVPGKCKHCGLQFPNVDVWLNKHVGKGCGYSYH
Protein: Stress-response A/B barrel domain-containing protein HS1 (Pop3 family protein At3g17210) (Protein HEAT STABLE 1) (AtHS1) (Q9LUV2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Heat stable protein involved in defense against fungal pathogens. Possesses antifungal activity against diverse pathogenic fungi. Possesses antimicrobial activity. Possesses ribonuclease activity.
Interaction partners:
- At5g02550
- Aminomethyltransferase, mitochondrial
- FAD-dependent oxidoreductase domain-containing protein 1
- Putative transferase At1g60990, chloroplastic
- Remorin 4.1
- Monodehydroascorbate reductase 1, peroxisomal
- Monodehydroascorbate reductase, chloroplastic/mitochondrial
- Monodehydroascorbate reductase 2
- Monodehydroascorbate reductase 4, peroxisomal
- Monodehydroascorbate reductase 3
Sequence:
MEEAKGPVKHVLLASFKDGVSPEKIEELIKGYANLVNLIEPMKAFHWGKDVSIENLHQGYTHIFESTFESKEAVAEYIAHPAHVEFATIFLGSLDKVLVIDYKPTSVSL
Protein: Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.8.27) (Medulla oblongata-derived protein) (Protein Mob) (Sphingomyelin synthase 1) (Transmembrane protein 23) (Q86VZ5)
Organism: Homo sapiens (Human)
Function: Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Does not use free phosphorylcholine or CDP-choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912, ECO:0000269|PubMed:18694848}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sphingomyelin phosphodiesterase
- Ceramide synthase 3
- Sphingomyelin phosphodiesterase 4
- Sphingomyelin phosphodiesterase 2
- Ceramide kinase
- Neutral ceramidase
- Ceramide synthase 2
- Ceramide glucosyltransferase
- Sphingolipid delta
- Acid ceramidase
Sequence:
MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRLLDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPMPELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
Protein: Transcription factor tau subunit sfc6 (TFIIIC subunit sfc6) (Transcription factor C subunit 6) (O60174)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with sfc3 in DNA binding. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Transcription factor tau subunit sfc3
- Transcription factor tau subunit sfc1
- Transcription factor tau subunit sfc4
- Putative transcription factor tau subunit sfc9
- Transcription factor IIIB 60 kDa subunit
- Transcription factor tau subunit sfc7
- DNA-directed RNA polymerase III subunit RPC2
- TATA-box-binding protein
- DNA-directed RNA polymerase III subunit rpc8
- Transcription factor TFIIIB component B''
Sequence:
MGPKSKEYENPSSYKNDEDNDDDGDFVLENVMSEEDIEIETPSRNRKRVSTTRRTPSKPIRSQPLTPSSSKGAGNEPKSQNSSTTRGSAKKQSSKGLEEKLINSYGTHVESLNKGRRLIEIWKYYETAPGQSSFEGQTSSDSKLQTLLNLDGQQLLSYSENPFYLFEVKNLSISFHFESPQQVEPCQPVNPFKENPQKSGFVVNTGIPLSSVSWLPTNKETQFLAVGGMLKFSETTESVFMRTSGRNQIQLWKLENKTNFKSEFILYHDWGSVLQLEWCPTISVEDSILGFLAVVCSDGKLRVLRVPRSPVKFHVFVEQADFTFGFNDSLISCCTWVSPEHGDIHQILVGCSNGYLALWDILSSQECPLFYIPYHDSYIHNVVQCLDDFPWLFLTTAFDCYTRIFDIRDPIIDNRPLSHKRDICYTITWNNMLQSIISCSESQSVVIESLRGTSTQLLDERNGSIISLSNSKFHPFVACAASDGIVTIVNPFRLLGFSHKQKANVHRIFQLEYSEKQDSYRMLDGFRPRLPKAKKLDMYIYPWQIQVNKVEWNGNKGYAGWLASGMACGILRVEDLSAVERR
Protein: Glyceraldehyde-3-phosphate dehydrogenase, putative (EC 5.3.1.1) (Q38E18)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Phosphoglycerate kinase
- Phosphoglycerate kinase
- Fructose-bisphosphate aldolase
- Glucose-6-phosphate isomerase
- Transaldolase
- Transketolase
- Glucose-6-phosphate 1-dehydrogenase
- Phosphoglycerate kinase
Sequence:
MEAETSKISEVPLPIPIGINGFGAVGRAVLFASMTEPQVTVVAVNDFSVSINYVLYVLQNESPLSAEDKASLTVVGEYIFYRGTERIRVTQKHDLVDIAWRDAGVSYVVECTGFTSTRDRCWGHLTSGARGVLVAGQSGDAPAIVAGVNDSDLSKIQPIICSGAPLAVALAPFIRILHESFGVEDCSYTAIHAIQPVEPNAARSANSQDWRQTRVTLDSITPYAHTGMTTFCKLMPTLSSRITGSAFQVPVTKGCAIDMLLRFKQPVAKESVDEALIEASKDRLKDVLFVSKRDFISRDLLPDGKLCYDPSASQCVREGELYKFTLWFDLERSFAKRLISLIPVMNDADAKKNNV
Protein: POU domain protein (Q5U4D4)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MDPGAGSDSSLTVNEQVIVMSGHETIRVLEVGVDAQLPAEEESKGLESVAAGGSQSGGPVEASGPAEAGSCDPDHSAEATVAARSPSESCPSDCHLQPSPEPASGITDPDAAGCTSCPPGQVAGQQGLAVWTIPTATVAALPGLTAASPTGGTFKPPLAGLQAAAVLNTALPTPVQAAPPIQASSPAQPRPPAQPQPLFQTQPLLQTTPAILPQPTAATVAAPTPKTVDATPQITVQPAGFAFSPGIISAASLGGQTQILGSLTTAPVITNTIPSMPGISSQILTNAQGQVIGALPWVVNSASVATPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPNTPESPAKSEVQPIQPTQAVPQPAVILTSPTPALKPSAATPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP
Protein: Oxidation resistance protein 1 (A4V2F2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MSIIDSGKYRLRKDWASASIPSLVNIDEHDGDSGDTEGSLNATAPLPPQKPPRRSSLALGLFSSKSDKSQKRRSSIAVSFLRRDSSKNSTKDSYESAVRSEKSDGSGTPTSPEIVYSSEENIRASSPNDPGKQTFFEDGSQSPRPVLQGLNTSYEGPQNDRQRRRRSSLQTKLDRHRRKKMEYSNQRSLDSGMMCSESHSDLTNDSLAEGSGSFANRSRNGNDDEDDIIDPSHGEYFPREKRHSWWNIFVPDNFKNRSKSRSVDHGLAAPFDLDSLRSKVEQRFESVDKLSRQKSSLPTIPTISYTVGNRDTLTSVAARFDTTPSELTHLNRLNSSFIYPGQQLLVPDKSAKDDASSSSTHDADGASLSGKSSPVERKLSGDESREKDILEGLRPGSPKPGHIERVGGSSQQQQAEEEANKSDDPVITQRFLKINVRHITDGQGVVGGVLLVTPNAVMFDPNVSDPLVIEHGPESYGVIAPMELVVNAAIFHDIAHMRVAGGAGQGLNSASGDAEKPEIYYPKPVLVEEDSKELPEQQSLLGEDGNKRLDAEIGSLEIADDQESLCSSTGRDGDAFPKAFDRERVEDSSMEAKDSAKTDALDDEDKKAGLGLSSTRSTLEERRKSLLDHHWAIPSKDRSSEDEGDNESNVTVDSGARVQDPHSANSSVSGVPLSQPPVAAAAAAAAVAPASAVVPLPPSGIDLEHLEQLSKQSCYDSGIDIREPVPNVQPIPKKTVYSDADIVLSSDWVPPKTIVPTHFSESPPRSTILGQSLDAGTGGAGGVRKKTSSVSFSVDDEAAQQAQAQSAALAVTDKQADKKNKMLKRLSYPLTWVEGLTGEGGAVPPGGVGSGSLNKSGDTDSAPNTGDSNQSVFSKVFSRRSSIGTFIRPHSSEGTSSSTKLKEAKQAPKLDYRSMVSMDDKPELFISVDKLIPRPARACLDPPLYLRLRMGKPIGKAIPLPTSVMSYGKNKLRAEYWFSVPKNRVDELYRFINTWVKHLYGELDEEQIKARGFELIQEDTEWTKSGTTKAGMGGGSQDGEEISDLTRESWEVLSMSTDEYRKTSLFATGSFDLDFPIPDLIGKTEILTEEHREKLCSHLPARAEGYSWSLIFSTSQHGFALNSLYRKMARLESPVLIVIEDTEHNVFGALTSCSLHVSDHFYGTGESLLYKFNPSFKVFHWTGENMYFIKGNMESLSIGAGDGRFGLWLDGDLNQGRSQQCSTYGNEPLAPQEDFVIKTLECWAFV
Protein: AP-3 complex subunit beta (Q9W4K1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004145}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004145}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004145}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
- AP-3 complex subunit delta
- Carmine, isoform A
- Adaptor protein complex AP-3 small chain sigma3
- AP-1 complex subunit gamma
- AP-2 complex subunit alpha
- Adaptor protein complex 1, mu subunit
- AP complex subunit sigma
- AP complex subunit beta
- Adaptor protein complex 2, mu subunit, isoform A
- Non-lysosomal glucosylceramidase
Sequence:
MQQNSASNPFAMSTYVERPQMGLDVEFGADPASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSESGSSSGSGTSDSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTHAVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERAKLRGMNEHQCELRGLRQDLIDVVALRQKVFESINVAHTHSSSSGQLHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMVLNELRNALQLSFAM
Protein: Nucleoporin 214 (M0RBV9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nuclear pore complex protein Nup88
- Nuclear pore complex protein Nup153
- Nuclear pore glycoprotein p62
- Nuclear pore complex protein Nup98-Nup96
- E3 SUMO-protein ligase RanBP2
- Nuclear pore complex protein Nup214
- Exportin-1
- Nuclear pore complex protein Nup133
- Nucleoporin 205
- Nuclear pore complex protein Nup107
Sequence:
RLNTDFQFRALKKVRIFDSPEELPKERSSVLTVSNKYGMLFAGGTNGLNVFPTKSLLIQNKPGDDPNKIVDTIQGLNVPMKFPVHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFTYHKLSNGASGMVNDMKWNPTVPSMAAVCLADGSISVLQVTDVVKVCATLPPSSGVTCVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYEADHPVRVLDVLWIGTYVFTIVYAGADGALETCPDVVMALLPVSL
Protein: Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor) (P30556)
Organism: Homo sapiens (Human)
Function: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.
Subcellular location: Cell membrane {ECO:0000269|PubMed:33713620}; Multi-pass membrane protein {ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768}.
Interaction partners:
- Angiotensinogen
- Guanine nucleotide-binding protein G
- Angiotensin-converting enzyme 2
- Type-1 angiotensin II receptor-associated protein
- Type-2 angiotensin II receptor
- B2 bradykinin receptor
- Angiotensin-converting enzyme
- Renin
- Kininogen-1
- Beta-arrestin-2
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
Protein: GH23019p (Q961H6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MFWVDLFDWIMHKEMALAPDTRVYENWKSPPIDLSLDIYLYNWTNPEDFGNLSTKPILEQVGPYRFIERPDKVDIHWHPENASVTYRRRSLFYFDAAGSNGSLDDEITTLNAVALSAAATAKYWPPVKRSLVDVGLKMYGAEMSVQKSIDELLFTGYNDAMIDVAMAMPIFGDEVKVPFDKFGWFYTRNGSADLTGVFNVFTGADQLAKLGQMHSWNYQENTGFFDSYCGMTNGSAGEFQPQHLKPGDSVGLFTPDMCRTIPLDYVETVDIEGLEGYKFSGGPRSVDNGTQYPENLCFCGGQCVPSGVMNISSCRFGSPVFMSYPHFFNADPYYPDQVEGLSPNQKDHEFYMVVQPSTGIPLEVAARFQVNMLVEPIQGISLYTGIPRIFFPLVWFEQKVRITPDMADQLKVLPIVMLSGHIFAGICLIVGITLLCWTPVQILLASCRNRRYDLRTKTKTNGQYKSRSQFSSAEELKSKASTLVCEKSVKGSPDSSPLLEKGRKPTIIKSQTGESVATASTAISDNKQD