wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc finger protein 436 (Q9C0F3)
Organism: Homo sapiens (Human)
Function: May be a transcriptional repressor.
Subcellular location: Nucleus {ECO:0000269|PubMed:17089209}.
Interaction partners:
- Transcription intermediary factor 1-beta
- Zinc finger-containing ubiquitin peptidase 1
- Polyubiquitin-C
- Ubiquitin carboxyl-terminal hydrolase 5
- Ubiquitin thioesterase OTU1
- Ubiquitin carboxyl-terminal hydrolase 44
- OTU domain-containing protein 7A
- Histone-lysine N-methyltransferase SETDB1
Sequence:
MAATLLMAGSQAPVTFEDMAMYLTREEWRPLDAAQRDLYRDVMQENYGNVVSLDFEIRSENEVNPKQEISEDVQFGTTSERPAENAEENPESEEGFESGDRSERQWGDLTAEEWVSYPLQPVTDLLVHKEVHTGIRYHICSHCGKAFSQISDLNRHQKTHTGDRPYKCYECGKGFSRSSHLIQHQRTHTGERPYDCNECGKSFGRSSHLIQHQTIHTGEKPHKCNECGKSFCRLSHLIQHQRTHSGEKPYECEECGKSFSRSSHLAQHQRTHTGEKPYECNECGRGFSERSDLIKHYRVHTGERPYKCDECGKNFSQNSDLVRHRRAHTGEKPYHCNECGENFSRISHLVQHQRTHTGEKPYECNACGKSFSRSSHLITHQKIHTGEKPYECNECWRSFGERSDLIKHQRTHTGEKPYECVQCGKGFTQSSNLITHQRVHTGEKPYECTECEKSFSRSSALIKHKRVHTD
Protein: Staufen double-stranded RNA binding protein 1 (Q5JW30)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKLGKKPMYKPVDPYSRMQSTYNYNMRGGAYPPRYFYPFPVPPLLYQVELSVGGQQFNGKGKTRQAAKHDAAAKALRILQNEPLPERLEVNGRESEEENLNKSEISQVFEIALKRNLPVNFEVARESGPPHMKNFVTKVSVGEFVGEGEGKSKKISKKNAAIAVLEELKKLPPLPAVERVKPRIKKKTKPIVKTSPEYGQGINPISRLAQIQQAKKEKEPEYTLLTERGLPRRREFVMQVKVGNHTAEGTGTNKKVAKRNAAENMLEILGFKVPQAQPTKPALKSEEKTPIKKPGDGRKVTFFEPGSGDENGTSNKEDEFRMPYLSHQQLPAGILPMVPEVAQAVGVSQGHHTKDFTRAAPNPAKATVTAMIARELLYGGTSPTAETILKNNISSGHVPHGPLTRPSEQLDYLSRVQGFQVEYKDFPKNNKNEFVSLINCSSQPPLISHGIGKDVESCHDMAALNILKLLSELDQQSTEMPRTGNGPMSVCGRC
Protein: Large ribosomal subunit protein uL1x (60S ribosomal protein L10a-3) (P59231)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein uL22z
- Large ribosomal subunit protein eL31x
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein uL4z
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein uL2x
- Large ribosomal subunit protein eL13z
Sequence:
MSKLQSEAVREAISSIITHCKETKPRNFTETIELQIGLKNYDPQKDKRFSGSVKLPHVPRPKMKICMLGDAQHVEEAEKIGLESMDVEALKKLNKNKKLVKKLAKKFHAFLASESVIKQIPRLLGPGLNKAGKFPTLVSHQESLESKVNETKATVKFQLKKVLCMGVAVGNLSMEEKQIFQNVQMSVNFLVSLLKKNWQNVRCLYLKSTMGPPNRVF
Protein: Lysine-specific demethylase jmjd-3.1 (EC 1.14.11.-) (JmjC domain-containing protein 3.1) (Q95QK3)
Organism: Caenorhabditis elegans
Function: Histone demethylase that specifically demethylates trimethylated 'Lys-27' of histone H3, a mark associated with transcriptional repression, thereby playing a central role in the histone code. Involved in the transcriptional regulation of the heat shock response, unfolded protein response and possibly other stress response target genes. Required for gonad development and organization. Required for the robust transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. Acts cell-autonomously in Y-to-PDA transdifferentiation, which depends on the demethylase activity and on recognition of the H3 tail. Cooperates with set-2 and unc-3 to ensure robust Y-to-PDA transdifferentiation. Promotes mitochondrial stress-induced longevity. Involved in lifespan regulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:25124442}.
Interaction partners:
- Lysine-specific demethylase 7 homolog
- ATP synthase subunit delta, mitochondrial
- ATP synthase subunit a
- F-ATPase gamma subunit
- Oligomycin sensitivity conferral protein
- WD repeat-containing protein wdr-5.1
- LIN-65L
- ATP synthase subunit d
- ATP synthase subunit alpha, mitochondrial
- ATP synthase subunit alpha
Sequence:
MQGKNSHLTGITGTTHFTIFGASPRSMSLVKNSQETPPFPGMNSTMRPVEFNSTKQPEAQTIDQEQDAPKSFDFKNQTLGVYSDTVLNPLKNDSFKDELVVDVQKNLPIESLTVSPKSSTDQNCRSTNEAIRIAGFDNFADQLQESNGVFEACPEAHSEQGNESEDFKDLINSETECNIEDVVLPTVHVSTDSEEIISGDVIMNDSNVVSKPKNLEKVETPDVLIGSGSNDKLSDMTEQIGNNQHLEKLISEKTEKSLSDNETTLKPVPVQHTNSVGSSIGTTSGDSEISDDDQKSWSPKNESLDYQPASTSSEFTETTSVANQTESNAGSVDDYCPRTSIDIGLDSSAPSCSSDATREPTPIKKRGRKKKEQSATEPPIPRTKRAYTKNPNTIRKRRMKKNQSDDEEDDGPPKRRTINYQIEFRDASGAWTMAQQLIFVRDFMSKKNDKIVKLSKSRQDRVDKFILQFQKTQDSHYMRAAIQLNTIFPDQGNYRHCQDYLKDLTIRVVVPPKRREGKRKSEVPANPPALLLTGPLYLNFYCTSQEVLEAAGQLLEFHVNAVYKDERLQPPVADKTLLDLERAMYHEQVKDLTDYHKYRIPCPTLTVTTKEEVFSSDFERILNSASITNISGIAKALNIKTELFSLPEIAKCHPELSIDILNQVPQSADGNCDSKGIRCWDVTSYSSKMKLQDFERYMQKEESEAMQAFETISNCTAKELESTCQKLKAERIAAQNAIEGCDETMPWIKFGTNIDLLSENFKKQMNEIEKLPTFLLPNREGNLLNYAGVDVLGINTVQMYAKPIGSRTPAHMENSLMASINWNRGPGTCVWFAVPYEYWGQLEFMIGEHGHKYQDQDYWPSEKELLELGVPVIKFEQKADEMVYVNTGCFHWVQSNSFCINVSWNVGQPNFTQLATSIVAHDHNMLIGNQAHVPLVNLVWNAARQRLFVDDPEMYKAMRGVMIRSLAHSKWYFDLIDHHDYIVGDASEWKLADRVQRCKYCTSEIFNIVRWYTTEDLSVDSYPFCSHCHVANEYKKDRFLKYTWFFSLETLVNIFDAYVPN
Protein: MFS siderochrome iron transporter C (Q4WHE1)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Major facilitator transporter that contributes to the maintenance of intracellular siderophore ferricrocin (FC) levels. Plays a role in conidiation and confers protection against oxidative stress. Contributes also to fungal virulence in the Galleria mellonella animal model system. Does not appear to play a role in either siderophore export or uptake.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=localizes intracellularly, possibly to vacuole-like structures, but not found in the plasma membrane or at the nucleus (PubMed:28367141). {ECO:0000269|PubMed:28367141}.
Interaction partners:
- GATA-type transcription factor sreA
Sequence:
MPFLDHRTGPSYGTIDQMEQHSDDEGERFLQEQCDTGRFSSDITSISEDSVQEGVRKIEAINLTWTARSLVIAYVSIFLMSFCTSLEGQTVMSLGAYATSAFSKHSLISTVLVVQNVVNAVIKPPMAKVADVFGRFEAFCVSILIYVLGYIQMAASTNVQTYASAQIFYSAGSTGLQILQQVFIADSSNLLNRAFLALLPEFPFLVTVWIGPTIADAVLKHASWRWGYGMWSIILPASFLPLALSLLLNQRKARRLNLIKPKSRPRGGVFAVLRRTWYDLDMGGLILLSAAVTLILVPLTLAANSKNGWKSDSIVAMIVVGLFCLIALPFWESSKRLAPKPLLSLHLLKQRTALAGCTLAFWYFMAFYFSVQPYFYSYLQVVQGYDVATAGRVTQTFAFTSTIAAFAVSILIKYTRRYRAFVIAGCVVYIIGMVLMMVTRHEGSTPAQILVTQVVVGIGGGLLNVPVQLGVQASASHQEVAAATAMFLTSMEMGGAVGAALSGAVWTHNIPRKLRLYLPEENKGDADAIFGKITKALSYPLGSPVRVAINQAYQETFKKLLILALIAIIPLVPLSLAMEDYKLDKMSEEPLVDPVPAEEGEIEPNRHVKRT
Protein: Vacuolar sorting protein Vps3844 C-terminal domain-containing protein (A0A1D8PQW4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MKWVNLLSWSSLFISSFALAESDSKHKHQQRRHDSNVYLLSNGKVVSNDDTTLLTKHEAMTYLDTFLELDEPYVKLGDNDQLIDLLNGLWDTKKLGSPKLIVNVKGEDLDATPMFKTKHLPLHKLMKNLVTNVPSVQLYKLTPELKYVTTTDNEVDSSSLVHHFNYFTEKLDSIWKQFNAKHQQEIQSYTPTNDKLFINELSQLIHLGEKINHTTGKSTDVFFFEVSSLLSIKRKIGSSSTTFIHAKEAMTDLLLKLSQTFDIIVVTFPQIQELSHLNKRNVELSVKSFQYGTQAACEVATNKCNSHGKCTQVGDNWACQCEPSFNKTTSKTTTWVGHDCSKKDVSVEANLFLWTSIALVVILVGGIQLMFGIGNDPLPGVLDAATIPKKSNL
Protein: Beta-lactamase-related domain-containing protein (Q9HT32)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Pyruvate dehydrogenase
- Probable beta-lactamase
- D-alanine--D-alanine ligase B
Sequence:
MRSCISVFRPALLALFVSASGSAGADAAVENPRIGRAADLYELIPEYQPDTYRNMDKVYPTRVIHKGTKVRPLPAGVAIAPRYRIGGEEYGVDDFMRRNRVGGVLILKDGKVALERYGLGNDERTRWTSFSVVKSISSTLVGAAVQQGLLALDQPVDKYLPSLAGSAYQGVTVEQVLQMSSGVRWNETYRDPKSDRRQMFDAQLAERPGGILRLLASLPRQYPSGTHFTYSTGESHLQSELLHAATRIPVSDYLSERIWARMGMESDGFWQLESPAGQEIGSSGLSATLRDYGRFGQFVLEDGVIDGERILPEGWVDRASRVEASSHLAPGKLYDGEYALGYGYQWWTFPVGAKALPEHDGGAFEAQGIFGQYLYINRKEKIVAVVWSAWPKPEMDDREEETYAFLGAAVKALR
Protein: Porphobilinogen deaminase (PBG) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) (P28789)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the tetrapolymerization of the monopyrrole porphobilinogen (PBG) into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Interaction partners:
- Uroporphyrinogen-III synthase
- Delta-aminolevulinic acid dehydratase
- Uroporphyrinogen decarboxylase
- 5-aminolevulinate synthase, mitochondrial
- Uroporphyrinogen-III C-methyltransferase
- Oxygen-dependent coproporphyrinogen-III oxidase
- Protoporphyrinogen oxidase
- Squalene epoxidase ERG1
- Ferrochelatase, mitochondrial
- Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating
Sequence:
MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILASAGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMACGKILAERMIADGAKKILDEINLDRIK
Protein: Adhesion G protein-coupled receptor L3 isoform X3 (Adhesion G protein-coupled receptor L3.1) (F1Q579)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MALTCPRRSFSESVQRSTGSSAVMWSTRLLFFFTLFTPVTLVLSRAPVPMAVVRRELSCEGYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENTRCYLPDAYKIMGFRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGVLRGVYQSEHLFESDHQAGSWCKDPLQSSNKIYYMPWTPYRTDTLTEYSSKEDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGRIVVSQLNPYTLRVEGSWDTSYDKRSASNAFMICGILYVVKSVYEDDDNEALGNKIDYMYNTEKSRETHLSIPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVIYSLDFGNNDNRLGFDPPSSVLLPDPLPPVRSSTTPPRPYTGTLRPSLTTTTTTTMVPPRRHNNVLPEALTRAPPSPQTPVTVDYCAPRLTAEISWPRTHQGQVAKQPCPPGTIGVATFNCLLGYWDPKGPDLSNCTSPWTNHITQRMRSGETAAIVARELAEQTKGELRPGDVPSTVKAMAQLVELLDVQLRNLTPGGKDTAARSLNKLQKRERSCRFFIQAMVETVNNLLQVRSQAAWRELSVAEQLRCATMLLDTVETGAFMLADNLLKTDTIQESTDNIQLEVARLSTDVNLADLSFPQSGLTGNSIHLSANTLKQQGRNGEIRMALVLYKNLGQYLSTENASVRLGSEAVYPNYSLIVNSPVITAAINKDSNKVYLSEPVVFTVKHIQQSEENFNPNCSFWSYSKRTMTGFWSTQDCRLLGTNRTHTSCSCTHLTNFAVLMAHVEVKKADQVHELLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFIAETLFLTGINRADQPIVCAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEYSRTKYFYLTGYGVPAVIVAVSAAVDYRSYGTERVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPDSGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCILQKKVRKEYGRCLRTHCCSGKSVESTISTSTKTSTARTPGRYSTNSQSRIRRMWNDTVRKQSESSFITADMNSSATLNRGTMANHLISNALLRPHGTNPYNTLLGESAVYNNPTANMFNTQEGILNNARDSSVMDTLPLNGNHGNSYGVAAGDYLTYSSRGSEPPTTLEKKILKELTANYAPSYLNTQERQGKAHQGTLTNKLNNHLANGGVAGSSSIPKDDVMVLDNPGAFHRHDDGGGLSLELIREESQAPLLPPRPPPPENHAPLHTFTAHRRLPQENSESFFPLLPNDTHSSHTHTPRAHTHSPLRDSLYTSMPTLTDLPHGTDDLINGLHDDEDEEEEEDGEEEEGSELHLANGKGVIMESDDVYYKSMPNLGSRNHIQELESYYQMGRGGSDGFIAPPEKEDSSPEEQPPDPSQLVTSL
Protein: Pyochelin biosynthetic protein PchC (Q9HWG2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Pyochelin synthase PchD
- Pyochelin synthetase PchE
- Pyochelin synthetase PchF
- Isochorismate pyruvate lyase
- Salicylate biosynthesis isochorismate synthase
- Pyochelin biosynthetic protein PchG
- Probable non-ribosomal peptide synthetase
- Fe
- Probable ATP-binding component of ABC transporter
- Probable ATP-binding component of ABC transporter
Sequence:
MSAAWVRPFRLTPMPRLRLACFPHAGGSASFFRSWSERLPPDIDLLALQYPGREDRFNEAPATRLEDLADGAALALRDFADAPLALFGHSLGAALAYETALRLESAGAPLRHLFVSAHPAPHRQRGGALHRGDEAALLEDVRRQGGASELLEDADLRALFLPILRADYQAIETYRRAQPIALACALDVLLGEHDEEVSAAEAQAWSDASRTPARLRRFPGGHFYLSEGRDAVIEHLLRRLAHPDALSREVA
Protein: Putative leucine-rich repeat receptor-like protein kinase At2g19210 (EC 2.7.11.1) (O65924)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Expressed protein
- Coiled-coil protein
- At1g52720
- Large ribosomal subunit protein uL1c
- Transmembrane protein
- SWIB complex BAF60b domain-containing protein
- Glycylpeptide N-tetradecanoyltransferase 1
- Disease resistance protein RPP2B
Sequence:
MVHYNFLSLIIFACFFAVFVLLVRAQDQSGFVSIDCGIPEDSSYNDETTDIKYVSDAAFVESGTIHSIDPEFQTSSLEKQFQNVRSFPEGNRNCYDVKPPQGKGFKYLIRTRFMYGNYDNLGKAPDFDLYLGFNIWDSVTIDNATTIVTKEIIHTLRSDHVHVCLVDKNRGTPFLSALEIRLLKSNTYETPYDSLILFKRWDLGGLGALPVRYKDDVFDRIWIPLRFPKYTIFNASLTIDSNNNEGFQPARFVMNTATSPEDLSQDIIFSWEPKDPTWKYFVYMHFAEVVELPSNETREFKVLLNEKEINMSSFSPRYLYTDTLFVQNPVSGPKLEFRLQQTPRSTLPPIINAIETYRVNEFLQSPTDQQDVDAIMRIKSKYGVKKSWLGDPCAPVKYPWKDINCSYVDNESPRIISVNLSSSGLTGEIDAAFSNLTLLHILDLSNNSLTGKIPDFLGNLHNLTELNLEGNKLSGAIPVKLLERSNKKLILLRIDGNPDLCVSASCQISDEKTKKNVYIIPLVASVVGVLGLVLAIALFLLYKKRHRRGGSGGVRAGPLDTTKRYYKYSEVVKVTNNFERVLGQGGFGKVYHGVLNDDQVAVKILSESSAQGYKEFRAEVELLLRVHHKNLTALIGYCHEGKKMALIYEFMANGTLGDYLSGEKSYVLSWEERLQISLDAAQGLEYLHNGCKPPIVQRDVKPANILINEKLQAKIADFGLSRSVALDGNNQDTTAVAGTIGYLDPEYHLTQKLSEKSDIYSFGVVLLEVVSGQPVIARSRTTAENIHITDRVDLMLSTGDIRGIVDPKLGERFDAGSAWKITEVAMACASSSSKNRPTMSHVVAELKESVSRARAGGGSGASSVTDPAMTNFDSGMFPQAR
Protein: FMRF-Like Peptide (FMRFamide-like peptide 12) (G5EBV5)
Organism: Caenorhabditis elegans
Interaction partners:
- FMRFamide-like neuropeptides 16
- FMRFamide-like neuropeptides 14
- FMRFamide-like neuropeptides 1
- FMRFamide-like neuropeptides 11
- FMRF-Like Peptide
- FMRFamide-like neuropeptides 22
- FMRFamide-like neuropeptide 18
- FMRFamide-like neuropeptides 7
- FMRFamide-like neuropeptides 6
- FMRFamide-like neuropeptides 3
Sequence:
MNVQVIIALLFCLIATCATQKVKGSPEVLPAAMYDGELSHESVNKISAQLLNALSELEALQEGNQQLKMAEKRRNKFEFIRFGRK
Protein: U4/U6 snRNA-associated-splicing factor PRP24 (U4/U6 snRNP protein) (P49960)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds preferentially to the U4/U6 hybrid snRNAs. Can stimulate the annealing of U4 and U6. Could participate in both the formation and disassembly of the U4/U6 hybrid during splicing.
Subcellular location: Nucleus.
Interaction partners:
- LSM complex subunit LSM2
- LSM2-LSM8 complex subunit LSM8
- LSM complex subunit LSM4
- LSM complex subunit LSM3
- LSM complex subunit LSM5
- LSM complex subunit LSM7
- LSM complex subunit LSM6
- Pre-mRNA-processing factor 31
- U4/U6 small nuclear ribonucleoprotein PRP3
- Pre-mRNA-splicing helicase BRR2
Sequence:
MEYGHHARPDSKRPLDEGSPAAAGLTSKKANEALTRNRELTTVLVKNLPKSYNQNKVYKYFKHCGPIIHVDVADSLKKNFRFARIEFARYDGALAAITKTHKVVGQNEIIVSHLTECTLWMTNFPPSYTQRNIRDLLQDINVVALSIRLPSLRFNTSRRFAYIDVTSKEDARYCVEKLNGLKIEGYTLVTKVSNPLEKSKRTDSATLEGREIMIRNLSTELLDENLLRESFEGFGSIEKINIPAGQKEHSFNNCCAFMVFENKDSAERALQMNRSLLGNREISVSLADKKPFLERNEVKRLLASRNSKELETLICLFPLSDKVSPSLICQFLQEEIHINEKDIRKILLVSDFNGAIIIFRDSKFAAKMLMILNGSQFQGKVIRSGTINDMKRYYNNQQNHSMKHVKPSCINMMEKGPNLQVKKKIPDKQEQMSNDDFRKMFLGE
Protein: Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) (P46414)
Organism: Mus musculus (Mouse)
Function: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (By similarity). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Subcellular location: Nucleus. Cytoplasm. Endosome {ECO:0000269|PubMed:20228253}. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-197, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 (By similarity). Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (PubMed:20228253). {ECO:0000250, ECO:0000269|PubMed:20228253}.
Interaction partners:
- Cyclin-A2
- G1/S-specific cyclin-E1
- Cyclin-dependent kinase 4
- G1/S-specific cyclin-D1
- G1/S-specific cyclin-D3
- Cyclin-dependent kinase 2
- S-phase kinase-associated protein 2
- Cyclin-dependent kinase 6
- Cyclin-A1
- G1/S-specific cyclin-D2
Sequence:
MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVNHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGRYEWQEVERGSLPEFYYRPPRPPKSACKVLAQESQDVSGSRQAVPLIGSQANSEDRHLVDQMPDSSDNPAGLAEQCPGMRKRPAAEDSSSQNKRANRTEENVSDGSPNAGTVEQTPKKPGLRRQT
Protein: WAS/WASL-interacting protein family member 1 (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) (Q6IN36)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. Plays a role in the formation of cell ruffles (By similarity). May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:11687573}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11687573}. Cell projection, ruffle {ECO:0000250}. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL.
Interaction partners:
- Actin nucleation-promoting factor WASL
- Actin nucleation-promoting factor WAS
- NCK adaptor protein 1.
- Src substrate cortactin
- Hematopoietic lineage cell-specific protein
- WAS/WASL interacting protein family, member 2
- Growth factor receptor-bound protein 2
- Cell division control protein 42 homolog
- Formin-binding protein 1-like
- Cofilin-1
Sequence:
MPVPPPPAPPPPPTFALANTEKPSLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGAGGGYGGGSGGGGGGGSSGGGGNFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPILPPGGRATSAKPFSSPSGPGRFPAPSPGHRSGPPEPPRNRMPPPRPDVGSKPDSLPPPVPNTPRPIPSSLHNRGSPAGLGAPRPPFPGNRGAAFGAGSVRQNLSSSSSPFPRPPLPPTPSRALDDKPPPPPPPVGNRPSMHREAVPPPPSQNSKPPVPSTPRPGAGSQAPPPPPPSRPGPPPLPPTSSDEIPRLPQRNLSLTSPTPPLPSPGRSGPLPPPPTERPPPPVRDPPGRSGPLPPPPPINRNGSTARALPATPQLPSRSGMDSPRSGPRPPLPPDRPGAGAPPPPPPSTSVRNGFQDSSCEDEWESRFYFHPISDLPPPEPYVPTTKTYPSKVARSESRSGSNRRERGAPPLPPIPR
Protein: Small ribosomal subunit protein uS12 (30S ribosomal protein S12) (P0A0X4)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: With S4 and S5 plays an important role in translational accuracy.
Interaction partners:
- Small ribosomal subunit protein uS5
- Nucleoside diphosphate kinase
- Translation initiation factor IF-1
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS15
Sequence:
MPTINQLIRKERKKVVKKTKSPALVECPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTSKFEVISYIPGEGHNLQEHSIVLVRGGRVKDLPGVKYHIVRGALDTAGVNKRTVSRSKYGTKKAKATDKKATDNKKK
Protein: Amyloid beta precursor protein binding family B member 3 (D6RBA1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGRGQYRGGAIVAVPCAPCDIYWCWPRPTHLWPHR
Protein: Cystathionine beta-lyase, chloroplastic (CBL) (EC 4.4.1.13) (Beta-cystathionase) (Cysteine lyase) (Cysteine-S-conjugate beta-lyase) (P53780)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:31002461}.
Interaction partners:
- Homocysteine S-methyltransferase 2
- Bifunctional cystathionine gamma-lyase/cysteine synthase
- Homocysteine S-methyltransferase 1
- Homocysteine S-methyltransferase 3
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 2
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 3, chloroplastic
- Adenosylhomocysteinase 2
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1
- Cysteine synthase 1
- Bifunctional L-3-cyanoalanine synthase/cysteine synthase C1, mitochondrial
Sequence:
MTSSLSLHSSFVPSFADLSDRGLISKNSPTSVSISKVPTWEKKQISNRNSFKLNCVMEKSVDGQTHSTVNNTTDSLNTMNIKEEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKTFPL
Protein: GTPase HflX (GTP-binding protein HflX) (O33230)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00900}. Note=May associate with membranes. {ECO:0000256|HAMAP-Rule:MF_00900}.
Interaction partners:
- GTPase Era
- Dethiobiotin synthetase BioD
- GTPase Der
- Large ribosomal subunit protein uL11
- Diaminopimelate epimerase
- Large ribosomal subunit protein bL32
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein bL19
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein bL27
Sequence:
MPANSDARPAATCHHRVLAMTYPDPPQTGLSDFTPSLGELALEDRSALRRVAGLSTELADVSEVEYRQLRLERVVLVGVWTEGSAADNRASLAELAALAETAGSQVLEGLIQRRDKPDPSTYIGSGKAAELREVIVATGADTVICDGELSPAQLTALEKAVQVKVIDRTALILDIFAQHATSREGKAQVSLAQMEYMLPRLRGWGESMSRQAGGRAGGSGGGVGLRGPGETKIETDRRRIRERMAKLRRDIRAMKQVRDTQRSRRRHSDVPSIAIVGYTNAGKSSLLNALTGAGVLVQDALFATLEPTTRRAEFGDGRPVVLTDTVGFVRHLPTQLVEAFRSTLEEVVHADLLVHVVDGSDGHPLAQIDAVRQVISEVIADHDGDPPPELLVVNKVDVASDLMLAKLRHGLPGAVFVSARTGDGIDALRRRMAELVVPADTAVDVVIPYDRGDLVARVHADGRIQQAEHKPEGTRIKARVPEALAATLREFAPRA
Protein: Killer cell lectin-like receptor subfamily C, member 2 (D3YXP2)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MSHLLGTEQASEPRKATKKTQAQFRFSNAAGDRLLEFSLQHASQKHLKASRHGYCKNFASPPEKLIAGILGTIWFTLLIALVISTRIVSPYINYTLSSAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLGSCLSKNCSLLHIDSEEEQDFLQSLSLVSWTGILRKGRGQAWDWKKDSIFKPKIAEISHDECNCAMMSASGLTADNCTTLHPYLCKCKFPI
Protein: DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) (G2WSP8)
Organism: Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137) (Verticillium wilt)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- YDG domain-containing protein
- DNA
- SET domain-containing protein
- Adenosylhomocysteinase
- S-adenosylmethionine synthase
- adenosylmethionine decarboxylase
- ubiquitinyl hydrolase 1
- Proliferating cell nuclear antigen
- Vezatin
- 40S ribosomal protein S27a
Sequence:
MPYFIYDDVDTSADDSSSTHSREVNGIPNSEDAYSGDTEGIIDDGYWPEVDDEWLPDGRRSSAPHDEDDDAATLQPGDPLPWENDEIGLVQDERGKTLGRLLSPSVDTLAKSRGFTVAIPESTLVHPVSSFSGFCAPAPERKEKCAVEALLKNPVSLPKDEFFEIELGQFVVYRHSASDRDKPPHRRQYPYEMRPLQTLCTKGAHSTLYADGILSHGDAKFFVRGIAFEELPLGNYGMAEPTVGDQIWISSTLNQRMGKQNLYYKLTTPAKEYARYHHGFLWVADLAKHVVDYMAAAGDKKRRVEFRHFKSHFHRWLIQAHGRDAVFNRWLDQYGRTDFRVAVNAYSDFIYKEAHGVLTSQQVFFHTFWKEIKSYTAYKPYGLVLNDASGRVSAGQSPEAEPSGPRGFDSASSLLGSNLRAQNGKRSSTPPPTVVTPYIYDCFAHMPFGHLLEEVNLSQRTEKLRNALIEQQHLQPGSHVDKSARHLDTTRVARAKGLQRPVRVGDVISTPRDEGLDSKWKREVAAGFDDVDRWLGLVQRIHISKAGKRSFDVIWIYRPVDTICGQMKYPWDNELFLSDHCSCYDKHDKIEEGEVLEIHAIQWGGSPTSADFFCRQTYLHEEHRWITLKEEHKMCSHRAPRVVDPDNYRVGETVLALLDPSGKRLEPCELVTAPTKPGVKMELRRLLRRIEVDPYSQARPNELVYSDEIYSVLLAAVYGRCLVRYYSPGETVQTPYDRDGVGNAFYISTYLQDTLGTKTCEPFSHERPFPKTFRQGMDPSEGFTKLQGFDLFCGGGNFGRGLEESGAVEMRWANDINMRAIHTYMANLDDPSRVSPFAGSIDDLARLALEGRFASNVPAVGEVDFVSGGSPCPGFSRLTVDKTTPNQRKNQSLVAAFASFIDMYRPKYGLLENVVEIIQGRKTREEDVFCQLICAIVGMGYQTHFFLLDAWTFGSPQSRSRIFLAFAAPGLRLPEVPMQSHRPLAMRSRSLGLLSNGEPMLRKTFTPTAFASVTARQALADLPDIADAKADCCIPFPDHRQSIGVTQLLRPQLGCIPTRPWGLNLGTAHNKGDGPMTAAELSLYPQAQRQGPSSKAFGRLRPDRLMGTITTKPSPSDGYGRAVLHWAQNRILTVMEARRAQGFRDHEVILGTPAEQWKTVGNSVAREVSLALGLSFRAAWLGSLIEGDEHLPLPRHMVRQPTMGGVEAERRKTQRQQPPADDEATLVQREGGDTPDTPLRHPAVERFTATHVSHSYPTPAKHGTPRRAMTPRRASSRRSSPTVAHGMTAYDPHDESIFGPETGLPIRKPRGDHERVTDWRGRRAVDETYAPPSDYESERTTTTSQDPEVWTPEPSRDLSATPATSVEGESRVDSAASARTRPANSVMYRLFTSKRKTAGEEKREAKRTCLP