Protein: Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP) (Q8I0G5)
Organism: Drosophila melanogaster (Fruit fly)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P32074, ECO:0000250|UniProtKB:P53620, ECO:0000250|UniProtKB:P53622}. Golgi apparatus membrane {ECO:0000269|PubMed:18398480, ECO:0000269|PubMed:18802472}; Peripheral membrane protein {ECO:0000269|PubMed:18398480, ECO:0000269|PubMed:18802472}; Cytoplasmic side {ECO:0000269|PubMed:18398480, ECO:0000269|PubMed:18802472}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:18398480, ECO:0000269|PubMed:18802472}; Peripheral membrane protein {ECO:0000269|PubMed:18398480, ECO:0000269|PubMed:18802472}; Cytoplasmic side {ECO:0000269|PubMed:18398480, ECO:0000269|PubMed:18802472}. Endoplasmic reticulum {ECO:0000269|PubMed:18398480, ECO:0000269|PubMed:18802472}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250|UniProtKB:P32074, ECO:0000250|UniProtKB:P53620, ECO:0000250|UniProtKB:P53622, ECO:0000269|PubMed:18398480, ECO:0000269|PubMed:18802472}.
Interaction partners:
- Coatomer subunit delta
- Coatomer subunit epsilon
- Coatomer subunit alpha
- Coatomer subunit beta'
- Coatomer subunit zeta
- Coatomer subunit beta
- ADP-ribosylation factor GTPase activating protein 3, isoform H
- Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
- ADP-ribosylation factor 1
- Protein transport protein SEC23
Sequence:
MNYFSLTSHKKHRGHPSAGPSNAYQNLEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHALGLLYHIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDIPSEELSDSPLFTFIESCLRHKSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLLGRCQMDPDDEVRDRATYYLSILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVKPVIANDVMLVTSSAPRPPKITREEESAARLAQLPGIQVLGPIHRSTAPIQLTESETEYTVQCIKHIFGQHVVFQFDCLNTLSDQILENVRVELTLPEGFTTRAVIPCPKLPYNDLQTTFVIVEFPPDAANSIATFGATLRFVVKDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVSWDAADSEEWLQAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENVPEGTHLHTLLCSGTFRGGAEILVRAKLALSEGVTLNLTVRSTDQDVAELITAAIG