wanglab/gogpt-training-data huggingface dataset:
Protein: Sin3A-associated protein 130, isoform C (Q8IQI0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Paired amphipathic helix protein Sin3a
- Inhibitor of growth protein
- FI07430p
- PHD finger protein 12
- BRMS1 transcriptional repressor
- BRCA2-interacting transcriptional repressor EMSY
- Chromatin assembly factor 1 p55 subunit
- Histone deacetylase HDAC1
- Lysine-specific demethylase 5
- Uncharacterized protein, isoform C
Sequence:
MSAPSEGGAGGGPVGGGSTATAPSAPLKTIKIRTQQLHTHAVPSLSLLPSIYPSSSSSSLAATGSLSASASLVSHSHPPLQLRGVINKYSLPSHLPSSAAHPAVAAKITHVKSDGGGGISIAGTPILSGGTIKVASANQVQQTSLGGTPIALNAGQATTAASIRAIGAGGQSTQVRVVMPMIKQLENVTATGRTQITAIPAAPARSGANASITVTRPVTQATYLPRASVTATQMGGVGVGVGQRLVTPLRATSSATVTPTAPTVLSSTGGFVRGATASVSRSGVALTSQPSSAVISSSNSGAWMQSQGQVQLIRTIHQPRQRIITTSAGVSNASVVTTTPVQAPTALSVSAGQPLATQQATGPGGGPQAYVATVLPQRQHQATLVYSSNVSAPNASQNPGQQFNPRFAVATPTGGVTTTTPGGTTVTPRQVRPIPLGKSFPTAKLNTTSISIRAPSIPQLNTSVTASPTAVSVSGGATVAPGRGPGAGGTALTATNLPTTRIIQLQQPATGTTQQIIGSGARLAGNVMLQPFLMSTTAAAKMGIRPPVTMTAKVQPSLTITQLNPIGKLSAGGGSGGQTMGPQGVASIQAVPVPNVSASVVNSSSVTGATSAAGGATVLPLTISGRGAGVGPGGNILTGTLTPIKNASGITLGKMMMAPASSAPGADGSSTSGATVTGFQRTWNPVVASQSQLMKIDEKGSAATIYYESMPASASTGVLSLTTTTVTQSTQAQAQLVSSAGGSLSVSSLPFASHATAGAGSGGGGSQATFTVLPSGAGGTATRTIGHQQLIIPAGPNSAPPQHMVIPLHTSVKVTTGAGNPQQATASGALVSSFMRKRDAEGSPIRAAKNLGPTLLSMASNNSGQNMPPAPGTTFNIQPVSVTVPQSVGSGLTVEALAKKERERVTHGVASSAASVPATVGPVNSTRNSRADSPASSDGSTTVSANSSPGVDQQLQDRIGDQPATGGAGGRDNSTHFNPINEMYSSHQSIQQNLGHSSLGARSGSSAFVDVQAPTPQQQQPQQVPHLVGSTQMQQGTRMNGTGNSSSSSYDCSSRKKPRRSTNDSQHSTQSQASLSLPPPSSEPTPPAGASYMQKHNNGGLLVTAATPGVAPNSAPGDANHRNSTPAVAGNKENANPVDFVIRRPRNCALLNTYKPTHKLANNHFHRYTDVKPREERRATVIDLANQPNVQGKINGWKIYHLRSQMEDLNESEVFSLGRLETMLQDLEKDKEKHSEIERVTELLKGNIQRSKIITDGINEAQNQLMKIFEHKPHVSNIITRCASKRNFKKREKI
Protein: Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3) (P12035)
Organism: Homo sapiens (Human)
Interaction partners:
- Keratin, type II cytoskeletal 5
- Keratin, type I cytoskeletal 14
Sequence:
MSRQASKTSGGGSQGFSGRSAVVSGSSRMSCVAHSGGAGGGAYGFRSGAGGFGSRSLYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGARYGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR
Protein: Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Micromolar-calpain) (muCANP) (O35350)
Organism: Mus musculus (Mouse)
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'. Cleaves and activates caspase-7 (CASP7).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P07384}. Cell membrane {ECO:0000250|UniProtKB:P07384}. Note=Translocates to the plasma membrane upon Ca(2+) binding. {ECO:0000250|UniProtKB:P07384}.
Interaction partners:
- Calpastatin
- Calpain small subunit 1
- Calpain-2 catalytic subunit
- Caspase-12
- BH3-interacting domain death agonist
- Bcl-2 homologous antagonist/killer
- Cyclin-dependent kinase 5 activator 1
- Apoptosis regulator BAX
- Interleukin-1 alpha
- Calpain small subunit 2
Sequence:
MTEELITPVYCTGVSAQVQKKRDKELGLGRHENAIKYLGQDYETLRARCLQSGVLFQDEAFPPVSHSLGFKELGPHSSKTYGIKWKRPTELMSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQDGYAGIFHFQLWQFGEWVDVVIDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTGAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDSSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLTPDALKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEEVDDADDYDNRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQIQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDLRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKLLDTDLDGVVTFDLFKWLQLTMFA
Protein: Inhibitor of growth protein (Q4VBS0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361213}.
Interaction partners:
- Protein Jade-1
- Bromodomain-containing 1a
- Chromatin modification-related protein MEAF6
- Bromodomain and PHD finger-containing, 1.
- Protein Jade-3
- Bromodomain and PHD finger-containing protein 3
- Centrosomal protein CCDC61
- Inhibitor of growth protein
Sequence:
MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKGQIDSLAREYTANARTLSSEQKLSLLRQIQQSYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESTDYDSTSSKGNKSDIRGPKKKEVNRARSKVKNSDDDCSSKSGQKKVKLTQSTEFSTPAVNFGNVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNTDCSIEWFHFACVGLTTKPRGKWYCPRCSQERKKK
Protein: 17.6 kDa class II heat shock protein (17.6 kDa heat shock protein) (AtHsp17.6) (P29830)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- 23.6 kDa heat shock protein, mitochondrial
- Chaperone protein ClpB1
- 26.5 kDa heat shock protein, mitochondrial
- 23.5 kDa heat shock protein, mitochondrial
- Heat shock 70 kDa protein 4
- Heat shock protein 90-1
- Heat shock 70 kDa protein 5
- Heat stress transcription factor A-2
- Heat shock protein 21, chloroplastic
- Heat shock 70 kDa protein 8
Sequence:
MDLGRFPIISILEDMLEVPEDHNNEKTRNNPSRVYMRDAKAMAATPADVIEHPNAYAFVVDMPGIKGDEIKVQVENDNVLVVSGERQRENKENEGVKYVRMERRMGKFMRKFQLPENADLDKISAVCHDGVLKVTVQKLPPPEPKKPKTIQVQVA
Protein: MADS-box transcription factor 7 (FDRMADS1) (MADS-box protein 45) (OsMADS45) (OsMADS7) (Protein AGAMOUS-like 6) (RMADS216) (Q0J466)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor. May be involved in the control of flowering time.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- MADS-box transcription factor 13
Sequence:
MGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSTQSMTKTLEKYQKCSYAGPETAVQNRESEQLKASRNEYLKLKARVENLQRTQRNLLGEDLDSLGIKELESLEKQLDSSLKHVRTTRTKHLVDQLTELQRKEQMVSEANRCLRRKLEESNHVRGQQVWEQGCNLIGYERQPEVQQPLHGGNGFFHPLDAAGEPTLQIGYPAEHHEAMNSACMNTYMPPWLP
Protein: Protocadherin 9 (A0A0A6YY37)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFNREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDEDAGENKAVTLSILNDNENFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDIDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKALHTLVLVFLYVNDTAGNTSYIYDLIRRTMETPLDRNIGDSGQPYQNEDYLTIMIAIVAGAMVVIVVIFVTVLVRCRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAELEEQGIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSDNCWMPPGLGPYQHPKSPLSTFAPQKEWIKKDKLVNGHTLTRAWKEDTNRNQFNDRKQYGSNEGHFNNGGHMADIPLANLKSYKQAGGTIESPKEHQL
Protein: NAC domain-containing protein 41 (ANAC041) (O22798)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator of the mannan synthase CSLA9. Recognizes and binds to DNA-specific sequence of CSLA9 promoter.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
Interaction partners:
- B3 domain-containing protein REM-like 3
- PLATZ transcription factor family protein
- At1g21000/F9H16_1
Sequence:
MEKRSSIKNRGVLRLPPGFRFHPTDEELVVQYLRRKVTGLPLPASVIPETDVCKSDPWDLPGDCESEMYFFSTREAKYPNGNRSNRSTGSGYWKATGLDKQIGKKKLVVGMKKTLVFYKGKPPNGTRTNWVLHEYRLVDSQQDSLYGQNMNWVLCRVFLKKRSNSNSKRKEDEKEEVENEKETETEREREEENKKSTCPIFYDFMRKDTKKKRRRRRCCDLNLTPATCCCCSSSTSSSSVCSSALTHTSSNDNRQEISYRENKFCLFL
Protein: Interferon-induced GTP-binding protein MxE (IFN-inducible antiviral protein MxE) (Interferon-inducible MxE protein) (Q800G5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Protein kinase-containing Z-DNA-binding domains
- Ubiquitin-specific peptidase 18
Sequence:
MSPSGSTKGESSGLNQHYEEKVRPCIDLVDSLRALGVEKDLNLPAIAVIGDQSSGKSSVLEALSGVALPRGTGIVTRCPLVLKLKKITKDKSWHGLLTYNDKIRELKDPAKIEKAVLNAQTALAGIGEGISHEMITLEIQSCDVPDLTLIDLPGIARVATGNQPEDIEKQIKSLIEKFIKRQETISLVVVPANIDIATTEALKMASTVDPTGQRTLGILTKPDLVDRGMEDTVVRTVNNEVIPLKKGYMIVKCRGQQDINDKLGLVEALEKERRFFDENVHFRSLLEDRKATIPLLAERLTKELVEHIAKNLPQLQNQLEMKLEKTSADLRGLGDGVPLDKNEKSNFLIMKIRQFNDVLERVQMAEEDVEKPNTRVFSKIRSEFVKWKRILDSKAIKTEETLRDEVQEYVKTRRGKELPGFVNYRTFENIVKKHIAELHEPALKLLKDVTDIVHSSVDHIVNAHFSSFSPLMRAAKDPTEDFLHEQFQRAEEKIHSQFRMEKIVYSQDDLYSDQLTTAKNTLRGYGLQSPNVSADVREMAYHLTSYLTIACERLANQIPLIVQYHMLNQYISQLQNAMLGLIGKNSPGMLLCEDSGVARKRKDLKERLERLKSAGRVLSKFVHSA
Protein: single-stranded DNA cytosine deaminase (EC 3.5.4.38) (B7TQM4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MALLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKKCHAEICFINEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLGIFASRLYYHWCKPQQKGLRLLCGSQVPVEVMGFPEFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLERIKS
Protein: Tetratricopeptide SHNi-TPR domain-containing protein (Q38EJ5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRQGRVRTESTVQRFAKTPIGEGFDLWDRDYLLGAMRLFLFKAETAPPFQVGPCMDATGEILVQLEELEDAREQFSIAAEKYLITQQQQLAKIMEIKALECERGPQAALEELTAFLKKETASTNATAVPAPITRAYAYQAELLLKTATPETPELFTEAVETAKLACNHAWDRVHMGYVVLGDALKASGCPDEARKAYSEAFETNRNCITALERHIEVLKEYIAESNDDMRIEALRKELLPLLESAISLHPRPTLIREKAFLLSETLGDAAALEFLDPLICNPPPEEADAAGNVGGRTVATLLKAKAAILADGGKMQEALEVAEAALKESPSDEEAKAIVAELRESL
Protein: Tubulin-specific chaperone D (Q9VQ78)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- ADP-ribosylation factor-like protein 2
- Tubulin-specific chaperone E
- Tubulin-binding cofactor B
- LD34582p
- Carbonic anhydrase
- Uncharacterized protein
- Tubulin beta chain
- MMS19 nucleotide excision repair protein
- Mitotic spindle assembly checkpoint protein MAD2A
- Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial
Sequence:
MSNSVEECKDEDLPANTLEHFTELQQVLEMIDNIKSIAANTFEREFEQYAQVLSRYQEQPHLLDPHLEELLGKLLHKIRKPDLDTGELHAAFKYLYIICKVRTYKVLVKFMPHELSDLEFVLDLLGQQNPKEFEQWETRYILLLWMSILVLNPFHMSRLDAYDTSTSAPTTNCSPVNHVQSKNTKMDRIFELIQLYVSSNDTCSSMAAFLAAKYFIRSDIKDLYLERFLDWIMEQHQADTLNVKFGQLAAVAAILKHGKREDLLPYADKLLQWITSCQYKDDNDFLKYKNYVKIIQRIGLVHLKPRIASWRYKRGTRSLATNLNQTTAAGGEPVVLEQSLEEGEEIVVPDAIEEVIEELLQALRSGGNDIRWSAAKGLGRVTNRLPKELADEVIGSVIDILNPLEPHEAWHGACLALAELAKRGLLLPHRLEELVPLLMQALFYDEMKGYMSVGQHIRDSACYMCWAFARAYNPDDVKPFVHKISSGLLTVAVFDREVNCRRAASAAFQESVGRLGNFPFGIEISTTTDFYSVGIRQNSYLNISDYIAQFEVYREPLINHLVQHKVSHWDSAIRELTAKALHKLSLWEPEYMAAVVLPQLLAKTDTIDINCRHGCVLAMGEITLTLRKLEEKSDPQVVYLSNQRVAELNELIITFLDKNFYRGMSGDLMKSCTSSYIKNCSLAKLQATPECLVSWQKVIDSCLITKSNAIRDGAVEAFGELCTTYYCSDSRHGENEAIINTYLTGADNDLEEHIRMGYIAALGVLPSFMIRCHLQAILDSLVKHSLTPLQAVLVGEMGDRENIQAYRWSEARTQSVLALTKLVKTVGYGGGIDSFAEPKNFNKVIECLLRALQEYTLDNRGDIGAWVREAAMSSLYEIVTTCPPDLLAPEQVHEIVVGFMQQAVEKIDRTRGLGGRLCCQLIHHQPRIPYIREHSKLLEIFPADADSVLWLFADHTFPLFCELLSLPDYSKRVLLGLSASIGQLTESLIKYASSALFHFLRSNPETVPRLCSEVVQIFEEHLLNERVTYPLLSFLDILIGSGTVESVLHDEANPFAEDIFRLLNLEVKGYKKLYKTATSISAFCQLLQVPRLSKRILSKLSVFLGLQHVHVRKTAATKLYEALALHGDVTEVPEENMDEILTLLSETDWTQPLVEVRPLRNQLCQLMDIKPPVSGAAAAAALQQASADK
Protein: DNA repair protein, putative (Q387H5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Polynucleotide kinase 3'-phosphatase, putative
- DNA excision repair protein, putative
- Adenylosuccinate synthetase
- DNA repair protein, putative
- DNA repair protein, putative
- DNA-repair protein, putative
- DNA repair protein, putative
- DNA mismatch repair protein, putative
Sequence:
MTSKHSAVLTITEKGDWRTAKNGEKVWRYMVQTAPTMRARCRKCSQPILKGDLKWGTPIRHSHGAYGWITAWHHVGCTRIAERKGFSDIVHGIDLLPPEKRAQVVAEVTSDSMPEHLLPLNPDDLVKKPLLPETEAPAELLRPLLRYQKEGLGWMVSQELSQVKGGILADEMGMGKTIQMISLFLARRLVGPTLVVCPVSSMLQWESEVKDHVVSGSLSVVVVSRTKNVRRDDIQNADVVLTTYPMLEQSWRELVNKKRVPCPYCQQLYLPRQLVVHNRYFCGPHAKKTSKQAKREKRQGGTGSSPTRKVQAKETIMKGLRTLRVDVDDNAEEGEDSVFEEGPRGVVGPMGLYRELMVEAGRKVRSRWDPAYVGSDSSGDTNNSTTESSTSSERDDSEEVLSKEEVADDKLSSFRCLHCGFQLLRYPFCPKIGQCHVLSDYMKQIIETDDGSDGVDLSQSVFHSVTWSRIVLDEAHRIKGSNTSTSRAAFALVGEHRWCLTGTPLQNRVGDVYSLVRFLRLAPYARYYCGTEGCSCSSFSHPFSGNDLRHCIFCGHGPVQHYAYFNRHILNPIIRYGYVGDGRRGMMMLSNEILQKCMLRRTKAERASDLHLPPMTVETFQVKLTDEERSFYESLYKKSTAAFDTFVEKGTVLHNYAHIFQLLSRLRQALDHPLIVINSMNVGGSSCSKGMCGICTESCGENSVQVDPCKHTFHRICLSQFVESQPLKEYNCPVCYVAINIDLRSLHSGWDEDGAQPVLPPELVHSDNESDENNVEEESKGRKLDDSAEGKSARARSVKKRGILSRIDSSKPLRGTKLDAITEYICSIPEEEKVIVFSQFGDTLDLIQLWLQKVKVKTVKLVGSLMLSQRQAVLRAFLHDKSVRAILISLKAGGEGLNLQIANHVVLVDPWWNPAVEMQAAQRAHRIGQTRPVRVVRFVTERSVEERMLELQEKKMLVIEGTIDGKVSSLQSLSEDDLQFLFTR
Protein: Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Q8CG71)
Organism: Mus musculus (Mouse)
Function: Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule. Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that have proline instead of 4-hydroxyproline in the third position (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IVL5, ECO:0000255|PROSITE-ProRule:PRU10138}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q8IVL5}. Golgi apparatus {ECO:0000250|UniProtKB:Q8IVL5}.
Interaction partners:
Sequence:
MRESTWVSLLLLLLLPTPQRGGPQDGRRSPEPEPERGPLQPFDLLYASGVAAYYSGDYERAVRDLEAALSSHRRLRDIRTRCARHCAARRPLAPPGAGPGAELPFFRAVLERARCSRSCQSQRLGGPASRHRVSEDVRSDFQRRVPYNYLQRAYIKLNQLEKAMEAAHTFFMANPEHMEMQQDLEDYKATARVEAPLLDREAKPHLESYNAGVKHYEADDFESAIKYFEQALREYFNEDMECRALCEGPQRFEEYEYLGYKGGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLMFHPDNEDVLDNVDFYESLLDDSTDPASIEAREDLTAFVKRHKLEAELIKLAAEGLGFSYAEPNYWISYGGRQDENRVPSGVNMDGAEVHGLSMGKKSPPKIGRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSQEQCRELHSVANGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKFGYEGRVPLKSARLFYDISEKARKIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFDGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTRGQRCAVALWFTLDPLYRELERIQADEVIAILDQEQRGKHGLNINPKDEL
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (G3V1K6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHSCLSPTIPV
Protein: Brevinin-1SN2 (E7EKH2)
Organism: Sylvirana spinulosa (Fine-spined frog) (Hylarana spinulosa)
Function: Antimicrobial peptide. Active against a variety of Gram-negative and Gram-positive bacterial strains. Active against fungus C.glabrata 090902 and C.albicans ATCC 10231. Shows hemolytic activity against human erythrocytes.
Subcellular location: Secreted {ECO:0000305|PubMed:24055160}.
Interaction partners:
Sequence:
MFTMKKSLLLIFFLGTINLSLCEEERNADEDEKRDGDDESDVEVQKRFMGTALKIAANVLPAAFCKIFKKC
Protein: IP14655p (Testis-specifically expressed bromodomain containing protein-2) (Q4V5A7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- IP01291p
- IP14417p1
- Transcription initiation factor TFIID subunit 8
- Uncharacterized protein
- Transcription initiation factor TFIID subunit 7
Sequence:
MASCKPLSVKLKLPNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVPTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKKLRGMPSGPEVPCNRDPKAVGRPRTNAPSSAQTERKCRELLKKLQSITNQTDAMTRNFFSNKWDSLQKKVDRQYFKSVNEFCLHVDGCFRKYHEPAKILYERVFNQPAAWCTSMNGNSSLESALNAADLNELLAAAKLTVNSLMQCVQMPGSGEPLTAKSLVETFCDTLNKMINKMEAGQRNSPNPSSSKRQKMSPEQETDLVQGEFKPAMELLSGNEIDNLMAVSIESSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQIEGFSSENCGDLSFDVKGLATDTMIMMKSAVTKATRAHSKLKLKDMQPSEKEGLQRALQSQLVNITRMLNKNRRRCGPLINFRNKNNTANNVVRKRATAPLTAKLKPLQANVMAPQLGAGVVETHNLSDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVVELQMSSSSSSESEMKSKSGRLSRSRSRSMSDTKLRPRSNSSASSRSNSSSSSGSNAGSSSGSRSRSSSSSSSSSNNSSESNDSSDVEVVPNVPEGQLRA
Protein: Cytosine deaminase (yCD) (EC 3.5.4.1) (Cytosine aminohydrolase) (Fluorocytosine resistance protein 1) (Q12178)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uracil phosphoribosyltransferase
- Cytidine deaminase
- Thymidylate synthase
- Uridine nucleosidase
- Deoxycytidylate deaminase
- Purine nucleoside phosphorylase
- tRNA-specific adenosine deaminase subunit TAD3
- Purine-cytosine permease FCY2
- Bifunctional purine biosynthesis protein ADE16
- Bifunctional purine biosynthesis protein ADE17
Sequence:
MVTGGMASKWDQKGMDIAYEEAALGYKEGGVPIGGCLINNKDGSVLGRGHNMRFQKGSATLHGEISTLENCGRLEGKVYKDTTLYTTLSPCDMCTGAIIMYGIPRCVVGENVNFKSKGEKYLQTRGHEVVVVDDERCKKIMKQFIDERPQDWFEDIGE
Protein: Homeodomain protein Nkx2.7 (NK2 transcription factor-related 7) (Q98873)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- GATA-binding protein 5
- Myosin, heavy chain 6, cardiac muscle, alpha
- GATA-binding protein 6
- Heart- and neural crest derivatives-expressed protein 2
Sequence:
MLPSPVTSTPFSVKDILKLEQQQALNPGVFMGVEQDSVPLQSLQLQCMQNTLSRSLDLLYSPEKGIPGEQVKCDDFDIVRSSCGSPTEEEMDANEETSMCPFTDSSYSSKNGETLREKPKQRLRRKPRVLFSQTQVFELERRFKQQRYLSAPERDHLALALKLTSTQVKIWFQNRRYKCKRQRQDKSLELAGPRRVAVPVLVRDGKPCHGAPYNVTVSYPYNNYYNSYGNNPYHCNFTSVPSFANTSQIPNHFVDMNLTTGSVDSIRTW
Protein: ADP-ribosylation factor-like protein 2 (Abnormal eversion of vulva protein 20) (Q19705)
Organism: Caenorhabditis elegans
Function: GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12015966}. Cell membrane {ECO:0000269|PubMed:12015966}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12015966}. Note=Some diffuse cytoplasmic expression is detected but expression is concentrated mainly next to centrosomes and is excluded from the mitotic spindle area. Localizes to the cortical plasma membrane of embryonic blastomeres.
Interaction partners:
- Protein unc-119
- Tubulin-specific chaperone D
- Phosphodiesterase delta-like protein
- Eukaryotic translation initiation factor 3 subunit G
- Tubulin-specific chaperone B
- C-CAP/cofactor C-like domain-containing protein
- Tubulin-specific chaperone E
- MItoGuArdin homolog
Sequence:
MGFLKILRKQRAREREMRILILGLDNAGKTTLMKKFLDEPTDTIEPTLGFDIKTVHFKDFQLNLWDVGGQKSLRSYWKNYFESTDALIWVVDSSDRERLLQCSEELKKLLGEERLAGASLLVLANKSDLPGAIDVNSIAQVLDLHSIKSHHWKIFSCCALSGDRLVQAMTWLCDDVGSRLFILD
Protein: DNA primase small subunit (EC 2.7.7.-) (DNA polymerase subunit A) (DNA polymerase subunit gamma) (DNA primase 50 kDa subunit) (dPRI50) (Q24317)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit PolA1, an accessory subunit PolA2 and two primase subunits, the catalytic subunit Prim1 and the regulatory subunit Prim2) is recruited to DNA at the replicative forks (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (By similarity). Can add both ribo- and deoxynucleotides during elongation of the primers. Binds single stranded DNA (By similarity).
Interaction partners:
- DNA polymerase alpha catalytic subunit
- DNA polymerase alpha subunit B
- DNA primase large subunit
- DNA polymerase delta catalytic subunit
- DNA polymerase epsilon catalytic subunit 1
- Replication factor C subunit 2
- DNA polymerase subunit gamma-1, mitochondrial
- DNA replication licensing factor Mcm5
- DNA polymerase epsilon subunit 2
- DNA polymerase delta subunit 2
Sequence:
MPEQVTDQENQAPQQQTTAVHAYNPEVLQDMLPVYYRRLFPHLPFYRWLSYGSSEDAIFSNREISFTLQDDIYIRYLCFDTQAELEKEICSRNPIKIDIGPVMHSKPKNHRSIPGGLTPVQRELVFDIDMTDYDEVRTCCSGAGVCLKCWKFMVLAARVLDVALREDFGFEHIIWIFSGRRGIHCWVCDYQARHLDGRGRYAVAEYLNIITYASFAGGNSPRCSMGDRPHHSLKRALKIVEPMFEEIVLEDQNLFGTPKGVTKLLNMVHDDAARGELESYMQKNLEDGAHSRLVWESFIKYANSMRTSTTSAWSRKLKNIVAEIQLGLLYPRLDINVTRGFNHLLKAPFCIHPATGKVCVPFSVSAVAKFDPTTVPTITQLLHEINAFDDKSKSYMEAPEDKSRIKDHKKTSMFKGVVVFEEFLRKLERSQKSASLQF
Protein: Serine/threonine-protein kinase fused (EC 2.7.11.1) (P23647)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2.
Interaction partners:
- Suppressor of fused homolog
- Kinesin-like protein costa
- Transcriptional activator cubitus interruptus
- Protein smoothened
- cAMP-dependent protein kinase catalytic subunit 1
- Protein hedgehog
- Protein patched
- Discs overgrown protein kinase
- Casein kinase I isoform alpha
- Protein kinase shaggy
Sequence:
MNRYAVSSLVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHVIEMIESFESKTDLFVVTEFALMDLHRYLSYNGAMGEEPARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYDHHADMWSLGCIAYESMAGQPPFCASSILHLVKMIKHEDVKWPSTLTSECRSFLQGLLEKDPGLRISWTQLLCHPFVEGRIFIAETQAEAAKESPFTNPEAKVKSSKQSDPEVGDLDEALAALDFGESRQENLTTSRDSINAIAPSDVEHLETDVEDNMQRVVVPFADLSYRDLSGVRAMPMVHQPVINSHTCFVSGNSNMILNHMNDNFDFQASLRGGGVAAKPIVAPTVRQSRSKDLEKRKLSQNLDNFSVRLGHSVDHEAQRKATEIATQEKHNQENKPPAEAISYANSQPPQQQPQQLKHSMHSTNEEKLSSDNTPPCLLPGWDSCDESQSPPIENDEWLAFLNRSVQELLDGELDSLKQHNLVSIIVAPLRNSKAIPRVLKSVAQLLSLPFVLVDPVLIVDLELIRNVYVDVKLVPNLMYACKLLLSHKQLSDSAASAPLTTGSLSRTLRSIPELTVEELETACSLYELVCHLVHLQQQFLTQFCDAVAILAASDLFLNFLTHDFRQSDSDAASVRLAGCMLALMGCVLRELPENAELVERIVFNPRLNFVSLLQSRHHLLRQRSCQLLRLLARFSLRGVQRIWNGELRFALQQLSEHHSYPALRGEAAQTLDEISHFTFFVT