wanglab/gogpt-training-data huggingface dataset:
Protein: Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1) (Q16881)
Organism: Homo sapiens (Human)
Function: Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2).
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:18042542}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:15199063}. Nucleus {ECO:0000269|PubMed:15199063}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15199063}.
Interaction partners:
- Thioredoxin
- Selenide, water dikinase 2
- Selenide, water dikinase 1
- Thioredoxin, mitochondrial
- Selenocysteine lyase
- Cystathionine gamma-lyase
- Thioredoxin reductase 2, mitochondrial
- Glutaredoxin-1
- Kynurenine--oxoglutarate transaminase 1
- Kynurenine--oxoglutarate transaminase 3
Sequence:
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG
Protein: DLG associated protein 5 (G3V4E5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPTLEGRILVELDETSQGLVPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQLQKLKEQREKAKRGIFKVGRYRPDMPCFLLSNQNAVKAEPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPRQTSEKKVSDKEKKVVQPVMPTSLRMTRSATQAAKQVPRTVSSTTARKPVTRAAN
Protein: Transcriptional regulator STP3 (Q5ANI6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor that activates genes required for degradation of extracellular protein and uptake of peptides such as the secreted aspartyl protease SAP2 or the oligopeptide transporter OPT1. Required for virulence. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes to the cytoplasm in its unprocessed form and is targeted to the nucleus after proteolytic processing upon induction by amino acids. {ECO:0000250}.
Interaction partners:
Sequence:
MLILSIGLIHHTSNKSLYTISPNKGKRYEPFTTTSLGNFQFHVVRFLHRLIYGTQRYQELFPPIQKIKNINNVKQQRIFPVNCAADDLDLGFGESDQIELFNHPSKDTYGQFNLIQLIDIFDPPQVHAPSSADEFFKSNKGSEHIDIFDMITRQPPPFHQHQLNIETPYFEDFATPLVLPPHEVSSDDVESYFSGSVSTVSSIEPLDDEFVPPPQPPRTHTSRKRKHDSISPPASSDSSSSSSYVPQLIPSSSSSVTSNGDSPVSPTTKRKYTKKKQPVFSNVDEPIVITTTTKTNNIDVKKITTTKNGTVENRFDCPSCDASFKVKGYLTRHLKKHSTSKAFECPFFDNHGVHGSKCHPTGGFSRRDTFKVHLRALHFIYPAGVKASQRNSFNGRCAGCFQYFDNNSEWLENHIEAGKCTGTVQYKQNVSNLLLD
Protein: Syntaxin-5 (Sed5 protein) (dSed5) (Q24509)
Organism: Drosophila melanogaster (Fruit fly)
Function: Mediates endoplasmic reticulum to Golgi transport.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:7929581}; Single-pass type IV membrane protein {ECO:0000269|PubMed:7929581}.
Interaction partners:
- Probable Golgi SNAP receptor complex member 2
- LD34211p
- BET1 homolog
- Secretory 22, isoform B
- Golgi SNAP receptor complex member 1
- LD27967p
- Protein sly1 homolog
- HL02043p
- General vesicular transport factor p115
- Alpha-soluble NSF attachment protein
Sequence:
MQTRRRLHQTDQQDYSSSSTYTIQEDQQGGAGAGSVGTGTAGGSVGLLAQSLVPPPTGHEAAIHIGDNYQSGDSISTPDYSDDKYGKAARQWNLRAFSGHALRTLSAAAAVVTGNQPGINNDSQSNYSYPASIPTSSQFYQSKEEPQETEPEPEIFVMAARDRTGEFANAIRSLQARNITRAVNIRDPRKAKQVQSYSEFMMVARFIGKNIASTYAKLEKLTMLAKKKSLFDDRPQEIQELTYIIKGDLNALNQQIARLQDISKDQRRHTNGKHLVSHSSNMVLALQSKLASMSTDFKQILEVRTENLKQQKTRRDQFSQGPGPLAAHTVSPSTAKQGSLLLSEENQAVSIDMGSSDTTPLLSTQTQMAIYDDSDNYVQQRAETMQNIESTIVELGGIFQQLAHMVKEQEEIVERIDTNVADAELNIEAAHGEILKYFQSVSKNRWLMIKIFGVLIFFFLFFVVFMS
Protein: Glucose-6-phosphate isomerase, cytosolic A (GPI-A) (EC 5.3.1.9) (Phosphoglucose isomerase A) (PGI-A) (Phosphohexose isomerase A) (PHI-A) (P42862)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:8722567}.
Interaction partners:
- Os06g0258900 protein
- phosphoglucomutase
- phosphoglucomutase
- Os01g0841600 protein
- Os09g0535000 protein
- Triosephosphate isomerase, cytosolic
- phosphopyruvate hydratase
- Enolase
- phosphopyruvate hydratase
- phosphopyruvate hydratase
Sequence:
MASSALICDTEQWKGLQAHVGEIQKTHLRHLMHDVERCKAMTAEYEGIYLDYSRQRATGETMEKLFKLAEAAKLKEKIEKMFRGDKINSTENRSVLHVALRAPRDEVINSNGVNVVPEVWGVKDKIKQFSETFRSGSWVGATGKALTNVVSVGIGGSFLGPLFVHAALQTDPEAAESAKGRQLRFLANVDPVDVARSIKDLDPETTLVVVVSKTFTTAETMLNARTLKEWIVSSLGPDAVAKHMIAVSTNLELVEKFGIDPKNAFAFWDWVGGRYSVCSAVGVLPLSLQYGFPIVQKFLEGAASIDKHFRSSSFEKNIPVLLGLLSVWNVSFLGYPARAILPYSQALEKFAPHIQQLSMESNGKGVSIDGVQLPFESGEIDFGEPGTNGQHSFYQLIHQGRVIPCDFIGVVKSQQPVYLKGEIVSNHDELMSNFFAQPDALAYGKTPEQLHSEKVPEHLIPHKTFQGNRPSLSLLLPSLSAYEIGQLLAIYEHRIAVQGFLWGINSFDQWGVELGKSLASQVRKSLHASRVEGKPVLGFNSSTTSLLTRYLAVEPSTPYNTTTLPKV
Protein: JmjC domain-containing protein (A0A131MBT2)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Set1/Ash2 histone methyltransferase complex subunit ash-2
- Retinoblastoma-binding protein homolog 5
- PAX-interacting protein 1
- PHD-type domain-containing protein
- WD repeat-containing protein wdr-5.1
- ATP synthase subunit a
- ATP synthase subunit delta, mitochondrial
- F-ATPase gamma subunit
- Oligomycin sensitivity conferral protein
- WD repeat-containing protein wdr-5.3
Sequence:
MNTVSLLTPPMDESEPLPEERHPGNFKKWLELPLLTNYELERIRTLSSLSFDEFHVQNPADLTYQVRLFFAKARQYLVRYVDEMKSIYKTHKYKTIERRIFYGLAKQCHVVLLANDWTGALELYQEVLSHHPDLFSHDPSMYFGLGLVYLHFKQWKPAIEAFTRLLYSFPTGMIALQAKVRLGVCYMELEDYNRCINLFKLAVNDSDESVFMPKFTIKYNIALSHENNDELEIAESEYENLITELTQHISFLQSKSNVDQQQVDLLISVKAACLRQIGWISYRRSYKDDANRLDHLKKAQENLISAHDTDPRDGQSYYYLGRVYGEHEPSVSGQVAHDAFVNYRFSIDKKEQNADTWCSIGALYQRQNQPIDALQAFICAIELNSTHSAAWTDLGELYEKNAQYQDALECFKNAMLNNPVAPEPIKARVQFLEKELSMPVPARPSNHASSSTFETVIPSLKEAYEQPIPLELRNRQDAAYADREAQYDNAFWDLWEDFRTMEHEKPEDMEWDVTYPRPMEDLEIQVMQLLRANEPALVKAEREVLECLETSEAVFKAKVIEYVIPEAVREMPRVTEEMIQNLRDHGHLLESPRCYSFPFLPKISFNDLPDSFSLLSELYVSMDISAQEIMQMVHRRTQPNSTYLPVFEEFAKLPEPPRGPVKPIVTDEDVRTALERSEKHPLILKTPILTVDNRKEAQSLELQRFLDGSTISCIRGLTGCLRLDLSLFSTKAVAEIDGNQEIEIRTQYQLPPETNCDHASQQTWQCVSDPSYTTVNKYAEYQSESFKHTLKGEAEKIKKNVGGTRGPSPKRMKLYKRASSPPKHLKSIKYGTNIDLSDDTKWGKQINELSKLPAFCRLIAGSNMLSHLGHQVHGMNTVKLFMKVPGCRTPAHQDSNHMASININIGPGDCEWFAVPYEYWGKMHKLCEKNGVDLLTGTFWPIIDDLLDAGIPVHRFTQKAGDMVYVSGGAIHWVQASGWCNNISWNVAPLNFQQLSISLLSYEYNKLRRFKSEVPMQLMCWQVAKNVKFTNQLIYNTCKGVLIRSLAFLRMVADYIVSQKKTIKAHTRTSGEQSHFCMTCECEVFCILFVKDIGGKFTVFCVYCAKSQGIEGFIALQQFSFTDLYSIYDNMKYIPAANNNKMSFTA
Protein: Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Complexed with cdc5 protein 8) (RING-type E3 ubiquitin transferase PRP19) (O14011)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable ubiquitin-protein ligase involved in pre-mRNA splicing (By similarity). May also function in DNA repair (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9UMS4}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D1
- Pre-mRNA-splicing factor brr2
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43
- Small nuclear ribonucleoprotein-associated protein B
- Pre-mRNA-splicing factor cwf19
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein E
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-splicing factor cwf11
Sequence:
MFCSISGETPKEPVISRVSGNVYEKRLIEQVIRETSKDPVTQQECTLEDLVPVKVPDFVRPRPPSATSLPALLSLFQEEWDSVALEQFELRRNLTETKQELSTALYSLDAALRVISRLTKERDEAREALAKFSDNIGTVSSKTIEVQEVEMGESDDQLKTSLRSTVEKTFQELSSKRKRTKLQPKWATDDAVSQLLQATPSTILENLETESTTSFFPSPENSSFVLCLHKDELLCLDIQSNSTLKIFEGSALACCWLTSSKIAVATADAISIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNEKCYIFSLKSQVYNITVAQHITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAVSLDITSQLLVSSDGETLYVHIYVKSSKSWRCMSQTHVSSISNLVWLNELHQLLFSTSNGAILRLG
Protein: Agamous-like MADS-box protein AGL70 (MADS box FLC1-like nuclear protein 3) (Protein AGAMOUS-like 70) (Protein MADS AFFECTING FLOWERING 3) (Q9LSR7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in the negative regulation of flowering time, probably through the photoperiodic and vernalization pathways; more efficient in cv. Landsberg erecta than in cv. Columbia background. Prevents premature flowering. Involved in the modulation of vernalization impact on flowering according to genotype acclimation to altitude.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Kinesin-like protein KIN-7F
- At4g02725
- Homeobox protein ATH1
- E3 ubiquitin-protein ligase RFI2
- Putative E3 ubiquitin-protein ligase XBAT35
Sequence:
MGRRKVEIKRIENKSSRQVTFSKRRKGLIEKARQLSILCESSIAVVAVSGSGKLYDSASGDNMSKIIDRYEIHHADELKALDLAEKIRNYLPHKELLEIVQSKLEESNVDNVSVDSLISMEEQLETALSVIRAKKTELMMEDMKSLQEREKLLIEENQILASQVGKKTFLVIEGDRGMSRENGSGNKVPETLSLLK
Protein: Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) (Q64471)
Organism: Mus musculus (Mouse)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Glutathione S-transferase Mu 1
- Glutathione S-transferase P 1
- Hematopoietic prostaglandin D synthase
- Glutathione S-transferase kappa 1
- Glutathione S-transferase A3
- Glutathione S-transferase omega-2
- Glutathione S-transferase Mu 5
- Glutathione S-transferase Mu 3
- Glutathione S-transferase A1
- Glutathione S-transferase A4
Sequence:
MVLELYLDLLSQPCRAIYIFAKKNNIPFQMHTVELRKGEHLSDAFARVNPMKRVPAMMDGGFTLCESVAILLYLAHKYKVPDHWYPQDLQARARVDEYLAWQHTGLRRSCLRALWHKVMFPVFLGEQIPPETLAATLAELDVNLQVLEDKFLQDKDFLVGPHISLADLVAITELMHPVGGGCPVFEGHPRLAAWYQRVEAAVGKDLFREAHEVILKVKDCPPADLIIKQKLMPRVLAMIQ
Protein: Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha) (P86252)
Organism: Rattus norvegicus (Rat)
Function: This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the c-Myc gene. May play a role in the initiation of DNA replication and in recombination (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P42669}.
Interaction partners:
Sequence:
FLKIAEVGAGGNKLTLSMSVAVEFRDYLGDFIEHYAQLGPSQPPDLAQAQDEPRYYMDLKENQRGPGLGSTQGQTIALPAQGLIEFRLIDDYGVEEEPAELPEGTSLTVDNKRFFFDVGSNKVSEVKPTYRFGHTFCK
Protein: SH3 domain-containing protein (Q7YTG2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPFYPPDDASISSETSEMFERDVNTLNRCFDDIERFVARIQSAALAQREIEQQNHRYRTANRRDKKNQQPPDPNGILFMRAQLPLESEFVDILKKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLAVILEACHWGLGRNVAPTVASPLLSLEARELMQNCLTSHESDIWMSLGEAWRTPPEDWTKPLPPPYRPIFNDGFAPYGVADRAMATPNQIHRGHSAPPEHFRQPPPRERNMVDTLEFDRLTLERERLEFEKAKIMERESRLRHEEKQIEDEKRRMHAEKDLITKETTQPVPPPAAVVTHQPITKRYDPPISISPPPQRNNYSHVKVTVDSDTSPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFDERNWWECKNMHQRVGYVPHTILSMVPFEQQQYASPNHHNNSSSTGGYNNGHHQGPAQNVYRPPPPPLVSDAGVQVEIRREHVAPPPPPVVIPPPPPPVRTPTMEELLRMQQQQQQKQRKPPVEEPVYQPQPAQRAGLEIWRRNQNPQLIQEVTETVGQHSGDILRPAMQRATRVAINEKSSPEDVTRWLQEKGFSPRVIDLLDGQDGANLFSLSKLHLQQACGRDEGGYLYSQLLVQKKRSGFRTHTGDELKAILNHRRTHVELSNEAAADEPVFTINPIL
Protein: CYFIP-related Rac1 interactor B (Protein FAM49B) (Q921M7)
Organism: Mus musculus (Mouse)
Function: Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling. Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (By similarity). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry. Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9NUQ9}; Lipid-anchor {ECO:0000250|UniProtKB:Q9NUQ9}. Mitochondrion {ECO:0000250|UniProtKB:Q9NUQ9}.
Interaction partners:
Sequence:
MGNLLKVLTCTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRINNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRFTNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIRSMLQ
Protein: Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) (Q96BR1)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
Subcellular location: Cytoplasmic vesicle {ECO:0000250}. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.
Interaction partners:
- 3-phosphoinositide-dependent protein kinase 1
- Serine/threonine-protein kinase Sgk2
- Forkhead box protein O3
- Forkhead box protein O1
- Forkhead box protein O4
- Serine/threonine-protein kinase Sgk1
- E3 ubiquitin-protein ligase NEDD4-like
- Ubiquitin-conjugating enzyme E2 G1
- Acid-sensing ion channel 1
Sequence:
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
Protein: Trypsin-modulating oostatic factor (TMOF) (P41495)
Organism: Sarcophaga bullata (Grey flesh fly) (Neobellieria bullata)
Function: Has an oostatic activity. Inhibits trypsin biosynthesis in the midgut which indirectly reduces the vitellogenin concentration in the hemolymph resulting in inhibition of oocyte development.
Interaction partners:
Sequence:
NPTNLH
Protein: Transcriptional activator protein TraR (P33905)
Organism: Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter)
Function: Positive regulation of conjugal transfer of Ti plasmids. TraR activates target genes in the presence of AAI and also activates traR and traI themselves.
Interaction partners:
Sequence:
MQHWLDKLTDLAAIEGDECILKTGLADIADHFGFTGYAYLHIQHRHITAVTNYHRQWQSTYFDKKFEALDPVVKRARSRKHIFTWSGEHERPTLSKDERAFYDHASDFGIRSGITIPIKTANGFMSMFTMASDKPVIDLDREIDAVAAAATIGQIHARISFLRTTPTAEDAAWLDPKEATYLRWIAVGKTMEEIADVEGVKYNSVRVKLREAMKRFDVRSKAHLTALAIRRKLI
Protein: pH-response transcription factor pacC/RIM101 (Regulator of IME2 protein 1) (pH-response regulator protein RIM101) (P33400)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself), mainly by repressing transcriptional repressors of those genes, and represses transcription of acid-expressed genes. Required for meiosis, sporulation and invasive growth.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- pH-response regulator protein palA/RIM20
- Calpain-like protease 1
- Transcriptional regulator NRG1
- pH-response regulator protein palF/RIM8
- pH-response regulator protein palI/RIM9
- pH-response regulator protein palH/RIM21
- Vacuolar-sorting protein SNF7
- Sodium/potassium exporting P-type ATPase 1
- Vacuolar-sorting protein BRO1
- Cytochrome P450-DIT2
Sequence:
MVPLEDLLNKENGTAAPQHSRESIVENGTDVSNVTKKDGLPSPNLSKRSSDCSKRPRIRCTTEAIGLNGQEDERMSPGSTSSSCLPYHSTSHLNTPPYDLLGASAVSPTTSSSSDSSSSSPLAQAHNPAGDDDDADNDGDSEDITLYCKWDNCGMIFNQPELLYNHLCHDHVGRKSHKNLQLNCHWGDCTTKTEKRDHITSHLRVHVPLKPFGCSTCSKKFKRPQDLKKHLKIHLESGGILKRKRGPKWGSKRTSKKNKSCASDAVSSCSASVPSAIAGSFKSHSTSPQILPPLPVGISQHLPSQQQQRAISLNQLCSDELSQYKPVYSPQLSARLQTILPPLYYNNGSTVSQGANSRSMNVYEDGCSNKTIANATQFFTKLSRNMTNNYILQQSGGSTESSSSSGRIPVAQTSYVQPPNAPSYQSVQGGSSISATANTATYVPVRLAKYPTGPSLTEHLPPLHSNTAGGVFNRQSQYAMPHYPSVRAAPSYSSSGCSILPPLQSKIPMLPSRRTMAGGTSLKPNWEFSLNQKSCTNDIIMSKLAIEEVDDESEIEDDFVEMLGIVNIIKDYLLCCVMEDLDDEESEDKDEENAFLQESLEKLSLQNQMGTNSVRILTKYPKILV
Protein: ELAV-like protein 1-B (Protein ElrA-B) (ElrA) (Q5U259)
Organism: Xenopus laevis (African clawed frog)
Function: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Acts cooperatively with cribp to stabilize AU-rich sequence (ARE)-containing mRNAs. May play a role during gastrulation. Required for the vegetal localization of vg1 mRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19458392}. Cytoplasm, cell cortex {ECO:0000269|PubMed:19458392}. Note=Enriched at the vegetal cortex in stage III and IV oocytes. Shows very weak nuclear localization. {ECO:0000269|PubMed:19458392}.
Interaction partners:
Sequence:
MSNGYEDHMDDVCRDDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYLNAKDAERAINTLNGLRLQSKTIKVSFARPSSETIKDANLYISGLPRTMTQKDVEDMFLPFGHIINSRVLVDQATGLSRGVAFIRFDKRSEAEEAIASFNGHKPPGSSEPITVKFAANPNQSKNMALLSQICHSPARRFGGPVHHQAQRFRFSPMGVDHMSSISSVNVASSASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKTLQVSFKTSKSHK
Protein: SSD domain-containing protein (Q19945)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- CHE-14 protein
- Protein dyf-7
Sequence:
MQILQIEPLVRNAFEWYGPVVHRWRWFCFISPLFLTLACSVGFFRMTELRVDDPSYVFTPSDARWRREISVFNENWPLDENKFLPGKSFEAKRFVNILIRAKDGGSIMRDNVLHEIEILNQWIMNNISIPTDDLKFNLTYQDLCLSYDWVCGANEHIQMLLRRNDVNQILDLHFPRGGTKDTPVYLGGIFGDVQFFQNGTLSDAKLTQLFYFLKQDQKMVEEYSSKFSYALETFLNQVYSSDVITLSFAHYQSLEDGLDENAKAFVPNFVVSFFVLAMYALVSSFTLKSSSATKIDWISSKPWLAAAGMFSTVLSIISAFGFLFILGVRYNVINTIIPFLIIAIGIDDMFLMNACWDQTSKSLSVPERMSKTLSHAGVAVTITNVTDVMSFAIGCITDLPGIQFFCIYACVSVAFSYFYQLTFFSGAMAIMGEVEREKRHCLFFYRTFQLVDISKMNEEADSKLQQIKSRSASPAPFNYLSSSNSSFSSDSDSFSSKKTIPAEFAWKEQQSPNSSLSKKSKDREEKDRIVHFIGKIYGPFILSNSVRIFSGLIFVVYLAIAMYGCYNFREGLNPGNLVTNDHYIAKYFSDIKHFWRIGAQLHVAVLNPPNLTISENRNELLKVVSAFENTQYTLGREGTVFFLLEYLNYLSELNAEVEDTERLWKTKLNSWLKYTGGSTQWASNLKINKTDGSFQAFRFQIALKNFVEPNDHKHAAQLLRDIADHQPFNVVVYHEAFPFADQYLIILPATIQNVVISLLCMAVVSFLLVPSLPSGFVIFVSIVSINIGVFGYMTLWGVNLDAVSMISIIMSIGFAVDLSAHIIYAFVTSHGDTKQRVIGALETLGWPIFQGASSTIAGISILYTVDAYIILVFFKTIWLTMLIGAIHGLFFIPIFLSLFPVEFFRIPKSSELH
Protein: ENTH/VHS/GAT family protein (F4JV51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
Sequence:
MVNAMVERATSEMLIGPDWAMNLEICDMLNSDPAQAKDVVKGIKKRIGSRNPKAQLLALTLLETIVKNCGDMVHMHVAEKGVIHEMVRIVKKKPDFHVKEKILVLIDTWQEAFGGPRARYPQYYAGYQELLRAGAVFPQRSERSAPVFTPPQTQPLTSYPPNLRNAGPGNDVPEPSAEPEFPTLSLSEIQNAKGIMDVLAEMLSALEPGNKEDLKQEVMVDLVEQCRTYKQRVVHLVNSTSDESLLCQGLALNDDLQRVLTNYEAIASGLPGTSSQIEKPKSETGKSLVDVDGPLIDTGDSSNQANGATSSSGNGVLNQLALPAPPVTNGSANSKIDLLSGDDLALVPVGPPQPASPVASDQNALALIDMFSDNTNNPSPATAPSGNPAQNIPLNPQGHQQPNSQAGEAGLQQSNGFAPQVGYSQFEQPSYGQGVSSPWSSQPAQQPVQPSYEGAQDSTAFPPPPWEAQLQDYSPSAESGSPFSPGMHPTQTAFTHAQPVNNNNPYPQIPQTGPPVNNNSPYAQMPQTGQAVANISPYPQIPQNGVYMPNQPNQALGSGYQPQQQQQQQMMMAQYYAQQQQLQQQQQQQAYGNQMGGYGYGYNQQQQGSSPYLDQQMYGLSMRDQTSHQVASSSSTTSYLPPMKPKNKPEDKLFGDLVDISKFKPTKPTSGRAGTM
Protein: ANKS1A protein (Q49AR9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSSIGEGIDFSQERQKISGSRTLEQSVGEWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLLSQTSSQLSQNDSCTGRSADLLLPPGDTGRRRHDSLHDPAAPSRAERFRIQEEHREAKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRATGASAAEMIETKSSKPVPKPRVGVRKSAVPLPPDSRCCYCHTCTTHRPSYLPLPSVSPGVKLEPPDMDQDAQSHASVSWVVDPKPDSKRSLSTNHTRLELVCCSQPENELVSTISGDKPKSFLEPLLFVMPTTAYNHNCPEWRSQKDGGCSTSECPHHLCLEKPGVLSLER
Protein: Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1) (Q08C38)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- COP9 signalosome complex subunit 5
- Ubiquitin carboxyl-terminal hydrolase 7
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin carboxyl-terminal hydrolase 4
- Ubiquitin carboxyl-terminal hydrolase 46
- Ubiquitin carboxyl-terminal hydrolase.
- OTU domain-containing protein 5-A
- Ubiquitin thioesterase
Sequence:
MGSTPCSGKGRGVGGFQELGCMPWKVSKQKGEALGGRGSELEDRPNAGTPPTSLQPPAIYHEKQHRELCALHALNNVFQDGAAFSRDALQDIYQRLSPSTLVTPHKKNMLGNGNYDVNVIMAALQTRGFEAVWWDKRRDVGSIALPNVTGFILNVPSNLRWGPLRLPLKRQHWIGVREVAGVYYNLDSKLRSPHAIGTADELRKFLRHQLRGKNCELLLVVSEEVEVHQTWKSDN