wanglab/gogpt-training-data huggingface dataset:
Protein: Actin-like protein 6B (53 kDa BRG1-associated factor B) (Actin-related protein Baf53b) (ArpN-alpha) (ArpNa) (BRG1-associated factor 53B) (BAF53B) (Q99MR0)
Organism: Mus musculus (Mouse)
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12437990}.
Interaction partners:
- Zinc finger protein DPF3
- Zinc finger protein neuro-d4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- SWI/SNF complex subunit SMARCC2
- SWI/SNF complex subunit SMARCC1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
- Calcium-responsive transactivator
Sequence:
MSGGVYGGDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGEKEKKGKIFHIDTNALHVPRDGAEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP
Protein: Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1) (Q8IZJ1)
Organism: Homo sapiens (Human)
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:25374360}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O08722}. Membrane raft {ECO:0000250|UniProtKB:O08722}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:O08722}.
Interaction partners:
- Netrin-1
- Neogenin
- Netrin receptor DCC
- Leucine-rich repeat transmembrane protein FLRT3
- Focal adhesion kinase 1
- Netrin-4
- Tyrosine-protein phosphatase non-receptor type 11
- Proto-oncogene tyrosine-protein kinase Src
- Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- Death-associated protein kinase 1
Sequence:
MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTLSDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGGFHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSLKVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRDPGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTVLSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDTPVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFYHIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLCSAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKASPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC
Protein: Putative MutL protein homolog 1 (DNA mismatch repair protein MLH1) (Q9P7W6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: This protein is involved in the repair of mismatches in DNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA mismatch repair protein msh2
- DNA mismatch repair protein pms1
- Exodeoxyribonuclease 1
- DNA mismatch repair protein msh6
- DNA mismatch repair protein msh3
- MutS protein homolog 1
- UPF0589 protein C32H8.01c
- DNA repair protein rhp51
- Crossover junction endonuclease mus81
- Fanconi-associated nuclease 1 homolog
Sequence:
MDVNSRAKIRPLDQLVINKIAAGEIIERPENAIKELIENSLDAGSTSIDVLLKDGGLKLLQITDNGSGIQYDDLPYLCQRFSTSKIDNFNDLQHLQTFGFRGEALASISHVAKVTVVTKLSSDIHAWKAFYVDGALAPISPGMSPAPQPCAGKQGTVITAEDLFYNVRSRKSALKNGSEEFRRIMILVQKYAIHNDQVSFNCKKVGDTVASLSLSSRLSKADKIRHIYGPRVASHLRDFSLGEGQSSIVGFSANGFISNADFQDKKSNLILFINNRLVESVELRHALEETYAKYLHKGASYFVYLSLNMSPEQLDVNVHPSKRIVHFLYDQEIATSICDKLGEILERTDTERSYPLQAMIPSISNTKNAESSSQKAVRTYENYLVRTDPRERSIKSMLSDNFLQRSSNNYDNEIIEKVDSANSNKNATNDIKDLQTEEIVEEGNSIDLESIKSLQKQVINSMHVLATNILTEHKYVGLVCPTRRIAAVQHNIGLYVVDYGKLSYHLFYQICLTEFGNYGEFVLETPLSISDLFEIVNGDEDKSESEKFTRLLVSRRDMLKDYFSISVTSGGLLTAVPMLSPKYHPPFEQLPLLISSLTPKFFDWLDEKSCLNGIMKAIAKFYVPLPLSYEESDVKSIRSLESCLEDYLFPEFRRRVICPKKVFEEKCIYQITSLPRLYNVFERC
Protein: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) (Q587C0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU361219}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361219}.
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase
- Mevalonate kinase
- Lanosterol 14-alpha-demethylase
- Squalene monooxygenase
- NAD
- Chromatin assembly factor 1 subunit A dimerization domain-containing protein
Sequence:
MLRRTLSCACGTGKTGWGAMSNAELVKAVSSRQLTFYGLEQALEPDYQRAIAVRREVVSDYVASSQSAEVKRKSLERIPFENYEWDRVVGQNCENIVGYVPIPLGMAGPIIMDGCEYPIPMATTEGALVASTHRGARAISQSGGCKTLILGEGMSRAPVVEVESLEEAGRLHNFCVENFTEIKAAFESTTRFGKLQSLKCVIIGRKAYIRFRATTGDAMGMNMITKGVDKALELIKQNFPSMKVIALSGNYCTDKKPSAVNWIEGRGKTVVAEALVRGELVERTLKCTVEDLVSLNIDKNLVGSAVAGSVGGFNAQAANVVAAIFIATGQDPAQVVESSTCITTMSKVGNDLLISVAMPSIEVGTVGGGTGLPAQSGCLDMIGCAGSNKEAPGANAQLLSRLVAAGVLSAELSLMSGLAAGHLLSAHMRLNRRK
Protein: Tyrosine-protein phosphatase MSG5 (EC 3.1.3.48) (P38590)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Dual specificity phosphatase that dephosphorylates MAP kinase FUS3 on both a Tyr and a Ser or Thr. Has a role in adaptation to pheromone.
Interaction partners:
- Mitogen-activated protein kinase FUS3
- Mitogen-activated protein kinase SLT2/MPK1
- Mitogen-activated protein kinase KSS1
- Tyrosine-protein phosphatase 3
- Serine/threonine-protein kinase KDX1
- Dual-specificity protein phosphatase SDP1
- Protein SST2
- MAP kinase kinase MKK1/SSP32
- Serine/threonine-protein kinase BCK1/SLK1/SSP31
- Protein STE5
Sequence:
MQFHSDKQHLDSKTDIDFKPNSPRSLQNRNTKNLSLDIAALHPLMEFSSPSQDVPGSVKFPSPTPLNLFMKPKPIVLEKCPPKVSPRPTPPSLSMRRSEASIYTLPTSLKNRTVSPSVYTKSSTVSSISKLSSSSPLSSFSEKPHLNRVHSLSVKTKDLKLKGIRGRSQTISGLETSTPISSTREGTLDSTDVNRFSNQKNMQTTLIFPEEDSDLNIDMVHAEIYQRTVYLDGPLLVLPPNLYLYSEPKLEDILSFDLVINVAKEIPNLEFLIPPEMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSKNSPGEEGETVHMPEEDDIGNNEVSSTTKSYSSASFRSFPMVTNLSSSPNDSSVNSSEVTPRTPATLTGARTALATERGEDDEHCKSLSQPADSLEASVDNESISTAPEQMMFLP
Protein: Ecto-ADP-ribosyltransferase 4 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 4) (ARTC4) (Dombrock blood group carrier molecule) (Mono(ADP-ribosyl)transferase 4) (NAD(P)(+)--arginine ADP-ribosyltransferase 4) (CD antigen CD297) (Q93070)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
Sequence:
MGPLINRCKKILLPTTVPPATMRIWLLGGLLPFLLLLSGLQRPTEGSEVAIKIDFDFAPGSFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHLAWLNQGKVLPQNMTTTHAVAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLHYYLTSAIQLLRKDSIMENGTLCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQEFGNQTLFTIFTCLGAPVQYFSLKKEVLIPPYELFKVINMSYHPRGDWLQLRSTGNLSTYNCQLLKASSKKCIPDPIAIASLSFLTSVIIFSKSRV
Protein: At4g31270 (Sequence-specific DNA binding transcription factor) (Q8GWR8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Nucleolar pre-ribosomal-associated protein
- Probable transcription factor At1g11510
- Homeobox-leucine zipper protein ATHB-23
- Ubinuclein-1
- Homeodomain-like superfamily protein
- Guanosine nucleotide diphosphate dissociation inhibitor 2
- Guanosine nucleotide diphosphate dissociation inhibitor 1
- Guanosine nucleotide diphosphate dissociation inhibitor At5g09550
- Transducin family protein / WD-40 repeat family protein
- Vacuolar protein sorting-associated protein 45 homolog
Sequence:
MEEGTSGSRRTRSQVAPEWAVKDCLVLVNEIAAVEADCSNALSSFQKWTMITENCNALDVSRNLNQCRRKWDSLMSDYNQIKKWESQYRGTGRSYWSLSSDKRKLLNLPGDIDIELFEAINAVVMIQDEKAGTESDSDPEAQDVVDLSAELAFVGSKRSRQRTMVMKETKKEEPRTSRVQVNTREKPITTKATHQNKTMGEKKPVEDMSTDEEEDETMNIEEDVEVMEAKLSYKIDLIHAIVGRNLAKDNETKDGVSMDDKLKSVRQQGDELIGCLSEIVSTLNRLHEVPQEIE
Protein: Peroxin-7 (Q4VQ66)
Organism: Leishmania major
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Peroxisome matrix {ECO:0000256|ARBA:ARBA00004253}.
Interaction partners:
- Putative peroxisome targeting signal 1 receptor
- Peroxisomal membrane protein PEX14
- Peroxin-13
- Putative 3-ketoacyl-CoA thiolase-like protein
- Thiolase protein-like protein
- Peroxin-12
- RING-type E3 ubiquitin transferase
- Alkylglycerone-phosphate synthase
- Phytanoyl-CoA dioxygenase
- Peroxisomal ATPase PEX6
Sequence:
MPSFQMHPGFAGQSIRTNPWKPTQFIISTSQNFGIVGSGKAYVVEAAPGFQAGSPVSLVGCWGTSDGVFDACFSEVDQNIVVTACGDGVKVYNLAMSLNRDGVIPLVHNAEHQAEVSCVTWNSAHRDTFYSASWDTTIKMYSAVKPEVSMVTMQEHFKEVYEVASTAHSPSSILSCSGDGSWKLWDNRSPQRSVLTQMAHQNQIVLSIDFCKSDPNIFASGGVDRTVRVWDARRPNQPLASFPGHDQACRRVRFSTHNPSMLASSGYDMRVCVWDLSKPQQPLTARYQHHREFVAGLEWSQAAPNALASASYDGSAFFWSVGQAATPSLPTQQLPPAVPPPRVPRPRTKVLAGLPQPSMPMPMAVTSPPRSPR
Protein: Extraembryonic, spermatogenesis, homeobox 1 (G3UXJ1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MENSLFNSMFLEEANYQEPEGFEPSRGEAAAPVAEAPQAWNGNENLGGGFLESNAQLGEADAAPVRQSLMRPLMQPVAQSSPQPLPANPLQAPQQPEEQ
Protein: Nicknack (RE19693p) (Q8SX40)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- IP01435p
Sequence:
MTPQCRLCGDLIYTQNPVNIFDENSKMVRQIALVTGLWLTDHSKMPRNMCSCCLLSLKSAIAFRQACIKTNNRLTIQRRSVEAKDDGCWADPLSDAHEGLKINDAEVEQEVLYEVSYADNEGLEEDHDLYKKEEEESEVNENKEFEDIACEIPFSKEDDEQEQQQEYEDMVDKKTGHDDGEESQECEESQPDEEESQQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDIEATSRQSALDEDKKPRRKYTKRSSPKNDDTDFLKPAKKKRKTYISQKVHICDHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQKEFNRYILNIHIRVKHRGEKPYACQFCDERFVHSTMRSRHENRVHRNKKTPKNFKCNYCDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHYRSRQHQNKLIAMSAKSEIDSKNK
Protein: BTEB2-like zinc finger protein (O77251)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
HTGEKPYVCSWPDCVWRFSRSDELARHKRSHSGVKPYKCDYCSKCFARSDHLTKHRKVHERGLLAASRAGRSLISDDLYAVRPGPKAKESVMTTFQGHDG
Protein: Glucosylceramidase (EC 3.2.1.45) (Q9VCJ4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Beta-galactosidase
- ceramide glucosyltransferase
- Beta galactosidase, isoform A
- Non-lysosomal glucosylceramidase
- Glucosylceramidase
- alpha-glucosidase
- Sphingomyelin phosphodiesterase
- Putative neutral sphingomyelinase
- Ceramide kinase, isoform A
- LD18904p
Sequence:
MGKMFASRGMLVLGVLLVSAIGGQSESIPCKLIDAEHGKVCVCTADYCDYLENPVLTDENEWFLISSSKQGLRFSTTSDKFGKEEKFTVQDYVEPTQETANATILSRLLDKVVDSAFTLESRESSITRTVTLRLDRSKTHQKMVGFGGSYTGAVEYLVENFKHSELADHLYKSFYAEDGLGFNLMRVSIGGCDFDLEPWSYAEEEGDTELSDMDELNAHDVTRVAQIKRLIEVSGVKNLLVKGAAWSSPPWMKTNNRWTGFGRLKRAYYQTWADYHLRWLRLMKDNGIPIWAISTGNEPLNGIIFMYFVKFMSLGWTPQTQAIWLNDYLGPTIRNSEFKDITLFGNDDQRYSFPHWFKMMNRTRPNSIDYLDGLSLHWYWDEIFGNSFIEQTKEYAPDKILIVSESCIGDKPWQAAAPLLGSWERAEKYARDYLLNIKLGFHGWIDWNICLDEIGGPNYVDNTVDAPVIVNTTTFEEFYKQPMFYAIGHFSKWVPEGSVRIDAVPSNVNLDSVAFLRPDNKITAVLFNSGRADLDITLVDSIRGQFVVNVPAKSIHTLLYS
Protein: CLAVATA3/ESR (CLE)-related protein 13 [Cleaved into: CLE13p] (Q6NMF0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular location: [CLE13p]: Secreted, extracellular space {ECO:0000250|UniProtKB:O49519}.
Interaction partners:
- CLAVATA3/ESR
- CLAVATA3/ESR
- CRIB domain-containing protein RIC2
- CLAVATA3/ESR
- Protein CLAVATA 3
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
Sequence:
MATTRVSHVLGFLLWISLLIFVSIGLFGNFSSKPINPFPSPVITLPALYYRPGRRALAVKTFDFTPFLKDLRRSNHRKALPAGGSEIDPRYGVEKRLVPSGPNPLHH
Protein: Protein CTR9 homolog (Protein EARLY FLOWERING 8) (Protein VERNALIZATION INDEPENDENCE 6) (B5X0I6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3). Involved in regulation of flowering time. Required for the expression of the MADS box genes and flowering repressors FLC, AGL27/FLM and AGL31/MAF2. Required for histone H3 trimethylation on 'Lys-4' H3K4me3 at the FLC and AGL27/FLM loci. Involved in the control of seed dormancy and germination.
Subcellular location: Nucleus {ECO:0000269|PubMed:20363855}.
Interaction partners:
- Protein LEO1 homolog
- Protein PAF1 homolog
- Protein CDC73 homolog
- Protein RTF1 homolog
- FACT complex subunit SSRP1
- FACT complex subunit SPT16
- WD repeat-containing protein VIP3
- FACT complex subunit
- Transcription elongation factor SPT6 homolog
- Transcription elongation factor SPT6-like
Sequence:
MASVYIPVQNSEEEVRVVLDQLPRDASDILDILKAEQAPLDLWLIIAREYFKQGKIEQFRQILEEGSSSDIDEYYADVKYERIAILNALGAYYSYLGKTETKNREKEEQFISATRYYNKASRIDMHEPSTWVGKGQLLLAKGEIDNALQAFKIVLDTAPDNVPALLGQASVEFNRGRFSESLQLYKRALQVFPGCPAAVRLGIGLCRYKLGQLDKARQAFDRVLQLDPDNVEALVALGIMDLQANDSIGMRKGMDRMQQAFEIYPYCASALNYLANHFFFTGQHFLVEQLTETALAVTTHGPTKSHSFYNLARSYHSKGDFEKAGMYYMAAIKETNNNPHEFVFPYFGLGQVQLKLGELKGSVFNFEKVLEVYPDNCETLKALGHLYTQLGQNEKALEYMRKATKLDPRDAQAFVGLGELLISSDTGAALDAFKMARTLMKKGGQEVPIEVLNDIGALHFEREEFESALENFKEALGDGIWISFLDEKENLEQTGVSVLGYKDTGIFHRLIESGHSVDVPWNKVTTLFNLARLLEQIHKTEAATFMYRLILFKYPGYIDAYLRLAASAKAQNNLPLAIELVNEALKVDDKNPNALSLLGELELKNDDWVKAKETFRAANDATDGKDSYAILSLGNWNYFAAMRNEKRNPKLEATHLEKAKELYTKVLTQHNSNMYAANGSGIVLAEKGQFDIAKDVFTQVQEAASGSVFLQMPDVWVNLAHVYFAQGNFALTVKMYQNCLRKFFYNTDSQILLYLARTHYEAEQWQECKKTLLRAIHLTPSNYTFRFDLGAVMQKSSSSTLQKKKRTADEVRSTVAEAENAVRVFTQLSAASDLHVHGFDSKKIQTHVQYCSHLLEAAKVHREAAEQEELQNRQRLEVARQAALAEEARRKAEEQRKYQLEKRKQEEELRRLKQEEEKFQRIKEQWKSSTPGSNKRKDRVEDDDGESKPSERRRKKGGKRRKKDKSSRARHYEDDEEEAATMDDHNEVEDEDANTNYNREDEMTTQEAEEPVDDDAHDLLAAAGLEDPDVDDDEVPTSGVRRRRALSSSDEEGELMEESHPNSSPQKEKEESNGEAGDPNMEEEEEEEEAN
Protein: Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Q9JLT0)
Organism: Rattus norvegicus (Rat)
Function: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
Subcellular location: Cell projection, lamellipodium {ECO:0000250}. Note=Colocalizes with MCC at the leading edge of migrating cells. {ECO:0000250}.
Interaction partners:
- Myosin light polypeptide 6
- Myosin regulatory light polypeptide 9
- Myosin-9
- Myosin regulatory light chain 12B
- Actin, cytoplasmic 1
- Myosin regulatory light chain RLC-A
- Actin, cytoplasmic 2
- Actin, aortic smooth muscle
- Actin, gamma-enteric smooth muscle
- Myosin-10
Sequence:
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEKPPHIYAISESAYRCMLQDRKDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIPIPGQQDKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGTSFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVDRIVGLDQVTGMTETAFGSAYKTKKGMFRNVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEGEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVLLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDELKVQLTKKEEELQGALARGDDETLHKNNALKVARELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGMKFAKDAAGLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIEGLEEAKKKLLKDVEALSQRLEEKVLAYDKLEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHIEGASLELSDDDTESKTSDVNETQPPQSE
Protein: Tellurite methyltransferase (EC 2.1.1.265) (Chalcogen-detoxifying protein TehB) (Selenite methyltransferase) (Tellurite resistance protein TehB) (P25397)
Organism: Escherichia coli (strain K12)
Function: S-adenosyl-L-methionine dependent methyltransferase that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Cannot methylate arsenic compounds.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:11053398}. Note=Probably a peripheral membrane protein that interacts with TehA.
Interaction partners:
- Tellurite resistance protein TehA
Sequence:
MIIRDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDKNAMSIANVERIKSIENLDNLHTRVVDLNNLTFDRQYDFILSTVVLMFLEAKTIPGLIANMQRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYYEGWERVKYNEDVGELHRTDANGNRIKLRFATMLARKK
Protein: Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS) (P29473)
Organism: Bos taurus (Bovine)
Function: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17071725}. Membrane, caveola {ECO:0000269|PubMed:17071725}. Cytoplasm, cytoskeleton {ECO:0000250}. Golgi apparatus {ECO:0000269|PubMed:17071725}. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. {ECO:0000250}.
Interaction partners:
- Calmodulin
- Calmodulin-like protein 4
- EF-hand calcium-binding domain-containing protein 11
- CALML5 protein
- Arginase-2, mitochondrial
- RAC-alpha serine/threonine-protein kinase
- Arginase-1
- Argininosuccinate lyase
- Caveolin-1
- Antizyme inhibitor 2
Sequence:
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPTLTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRCCLGSLVLPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPDPWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKAAAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRATILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPGGPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGIAPFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFSREPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGPDTPGP
Protein: Delta and Notch-like epidermal growth factor-related receptor precursor (Delta/notch-like EGF-related receptor) (S4TYY2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MQLFILPLLLLLLGEMDGLFGTPLTSSPGPGEDPSTAPDPCEGRPCLNGGVCSRLGEMEDSQSTQMQTLEPWAYICVCSRGFTGQNCEFFADPCASSPCLHGNCSQDGEGEGFTCECSEGYSGARCDLPTLTFDLSESTWDLAESLVPEHATPATPATPATTTQVLQPTTVLTTTQAPPTLEPWQPRAGQRVLEILWDDQQITNEAECVSTAGGESAGMMSISLELAEETAVKLVGNVSGSAVLWRVGASGYEQCSVADGTIMWFQQSSEGLVLPDQSLPLGHNYFITLLVGSPSGPEVTLRLHLLVKTNNCMEPGSAFSDPQCSGKGKCVTQSSVDTFYCRCDDGYSGIFCEEFDACHLKPCENNGSCADLRQRDEGQNYTCTCQTGFEGERCQSLVDHCVSGPCRNGATCSSSLEGPHCYCAEGYQGIMCEQKIDPCASGPCHNNASCSPQGAGLGFSCTCPAGFTGPTCAQLVDFCALNPCAHGICRSIGTSYRCLCVPGYHGLYCEEEYNECLSAPCQNYATCRDLINAYECICASQFTGKHCEIYKDPCLKLRCQNGGHCESGGRNASCVCPPGYMGENCEVDVNECESNPCHHGGTCIDQSNGYTCHCPPGWVGGSCEIHLQWKMAQPVDSLTNMPRHSLYIIIGALCVAFVLMLIILIVGICRISRIEYQGSSRHAYQEFYNCRSIDSDFSNAIASIRHARFGKKSRPAMYDATPISYEDYSPDDKPLVALIKTKDL