wanglab/gogpt-training-data huggingface dataset:
Protein: GDSL esterase/lipase LTL1 (EC 3.1.1.-) (Extracellular lipase LTL1) (Lithium-tolerant lipase 1) (AtLTL1) (Li-tolerant lipase 1) (Q9M8Y5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the mechanisms of salt tolerance. Mediates resistance to LiCl and NaCl.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- GDSL esterase/lipase
- Kunitz trypsin inhibitor 3
- Acetyl-CoA:benzylalcohol acetyltranferase-like protein
- Putative casein kinase II subunit beta-4
- Probable lysophospholipase BODYGUARD 3
- Probable inactive patatin-like protein 9
- Protein WVD2-like 1
Sequence:
MNINCSPLGFLISLFFIVTFLAPQVKSRAFFVFGDSLVDNGNNDYLVTTARADNYPYGIDYPTRRPTGRFSNGLNIPDIISEAIGMPSTLPYLSPHLTGENLLVGANFASAGIGILNDTGIQFVNIIRISKQMEYFEQYQLRVSALIGPEATQQLVNQALVLITLGGNDFVNNYYLIPFSARSRQYALPDYVVYLISEYGKILRKLYELGARRVLVTGTGAMGCAPAELAQHSRNGECYGALQTAAALFNPQLVDLIASVNAEIGQDVFVAANAYQMNMDYLSNPEQFGFVTSKVACCGQGPYNGIGLCTPVSNLCPNRDLYAFWDAFHPTEKANRIIVNQILTGSSKYMHPMNLSTAMLLDSSKI
Protein: Neuritin (O08957)
Organism: Rattus norvegicus (Rat)
Function: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Synapse {ECO:0000305|PubMed:22632720}.
Interaction partners:
- von Willebrand factor C domain containing 2
- Protein cornichon homolog 2
- von Willebrand factor C domain containing 2 like
- Voltage-dependent calcium channel gamma-3 subunit
- Glutamate receptor 1
- Glutamate receptor 2
- Noelin-3
- ELAV-like protein 4
- Glutamate receptor ionotropic, NMDA 1
- Voltage-dependent calcium channel gamma-4 subunit
Sequence:
MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSGNGAAGSLLPALSVLLVSLSAALATWLSF
Protein: Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) (O35618)
Organism: Mus musculus (Mouse)
Function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform.
Subcellular location: Nucleus.
Interaction partners:
- E3 ubiquitin-protein ligase Mdm2
- Cellular tumor antigen p53
- Serine-protein kinase ATM
- Ubiquitin carboxyl-terminal hydrolase 7
- 14-3-3 protein sigma
- Serine/threonine-protein kinase Chk2
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-B
- Cyclin-dependent kinase inhibitor 1
- Polyubiquitin-C
Sequence:
MTSHSTSAQCSASDSACRISSEQISQVRPKLQLLKILHAAGAQGEVFTMKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGDLLGCQSFSVKDPSPLYDMLRKNLVTSASINTDAAQTLALAQDHTMDFPSQDRLKHGATEYSNPRKRTEEEDTHTLPTSRHKCRDSRADEDLIEHLSQDETSRLDLDFEEWDVAGLPWWFLGNLRNNCIPKSNGSTDLQTNQDIGTAIVSDTTDDLWFLNETVSEQLGVGIKVEAANSEQTSEVGKTSNKKTVEVGKDDDLEDSRSLSDDTDVELTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSNITAIPEKKDNEGIDVPDCRRTISAPVVRPKDGYLKEEKPRFDPCNSVGFLDLAHSSESQEIISSAREQTDIFSEQKAETESMEDFQNVLKPCSLCEKRPRDGNIIHGKTSHLTTCFHCARRLKKSGASCPACKKEIQLVIKVFIA
Protein: Carboxysome shell protein CcmK2 (Carbon dioxide-concentrating mechanism protein CcmK2) (Q8DKB2)
Organism: Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)
Function: Probably the major shell protein of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome. The hexamer central pore probably regulates metabolite flux.
Subcellular location: Carboxysome {ECO:0000255|HAMAP-Rule:MF_00854, ECO:0000305|PubMed:22748766, ECO:0000305|PubMed:24504539}. Note=This cyanobacterium makes beta-type carboxysomes. {ECO:0000269|PubMed:22748766}.
Interaction partners:
- Carboxysome shell vertex protein CcmL
- Carboxysome assembly protein CcmM
- Ribulose bisphosphate carboxylase small subunit
- Ribulose bisphosphate carboxylase large chain
- Carboxysome shell protein CcmK1
- Glycolate oxidase subunit
- Carbon dioxide concentrating mechanism protein
- Tlr0311 protein
Sequence:
MPIAVGMIETRGFPAVVEAADAMVKAARVTLVGYEKIGSGRVTVIVRGDVSEVQASVAAGVDSAKRVNGGEVLSTHIIARPHENLEYVLPIRYTEAVEQFRN
Protein: Aspartic proteinase yapsin-3 (EC 3.4.23.-) (Q12303)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cleaves proteins C-terminally to mono- and paired-basic residues. Required for cell wall integrity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10191273, ECO:0000269|PubMed:11016834}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10191273, ECO:0000269|PubMed:11016834}. Note=GPI-anchored plasma membrane protein (GPI-PMP).
Interaction partners:
Sequence:
MKLQLAAVATLAVLTSPAFGRVLPDGKYVKIPFTKKKNGDNGELSKRSNGHEKFVLANEQSFYSVELAIGTPSQNLTVLLDTGSADLWVPGKGNPYCGSVMDCDQYGVFDKTKSSTFKANKSSPFYAAYGDGTYAEGAFGQDKLKYNELDLSGLSFAVANESNSTFGVLGIGLSTLEVTYSGKVAIMDKRSYEYDNFPLFLKHSGAIDATAYSLFLNDESQSSGSILFGAVDHSKYEGQLYTIPLVNLYKSQGYQHPVAFDVTLQGLGLQTDKRNITLTTTKLPALLDSGTTLTYLPSQAVALLAKSLNASYSKTLGYYEYTCPSSDNKTSVAFDFGGFRINAPLSDFTMQTSVGTCVLAIIPQAGNATAILGDSFLRNAYVVYDLDNYEISLAQAKYGTGKENVEVIKSTVPSAIRAPSYNNTWSNYASATSGGNIFTTVRTFNGTSTATTTRSTTTKKTNSTTTAKSTHKSKRALQRAATNSASSIRSTLGLLLVPSLLILSVFFS
Protein: Taste receptor type 1 member 3 (Sweet taste receptor T1R3) (Q923K1)
Organism: Rattus norvegicus (Rat)
Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Taste receptor type 1 member 1
- Guanine nucleotide-binding protein G
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Transient receptor potential cation channel, subfamily M, member 5
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Sodium/glucose cotransporter 1
- Pro-glucagon
- Taste receptor type 2 member 105
Sequence:
MPGLAILGLSLAAFLELGMGSSLCLSQQFKAQGDYILGGLFPLGTTEEATLNQRTQPNGILCTRFSPLGLFLAMAMKMAVEEINNGSALLPGLRLGYDLFDTCSEPVVTMKPSLMFMAKVGSQSIAAYCNYTQYQPRVLAVIGPHSSELALITGKFFSFFLMPQVSYSASMDRLSDRETFPSFFRTVPSDRVQLQAVVTLLQNFSWNWVAALGSDDDYGREGLSIFSGLANSRGICIAHEGLVPQHDTSGQQLGKVVDVLRQVNQSKVQVVVLFASARAVYSLFSYSILHDLSPKVWVASESWLTSDLVMTLPNIARVGTVLGFLQRGALLPEFSHYVETRLALAADPTFCASLKAELDLEERVMGPRCSQCDYIMLQNLSSGLMQNLSAGQLHHQIFATYAAVYSVAQALHNTLQCNVSHCHTSEPVQPWQLLENMYNMSFRARDLTLQFDAKGSVDMEYDLKMWVWQSPTPVLHTVGTFNGTLQLQHSKMYWPGNQVPVSQCSRQCKDGQVRRVKGFHSCCYDCVDCKAGSYRKHPDDFTCTPCGKDQWSPEKSTTCLPRRPKFLAWGEPAVLSLLLLLCLVLGLTLAALGLFVHYWDSPLVQASGGSLFCFGLICLGLFCLSVLLFPGRPRSASCLAQQPMAHLPLTGCLSTLFLQAAEIFVESELPLSWANWLCSYLRGPWAWLVVLLATLVEAALCAWYLMAFPPEVVTDWQVLPTEVLEHCRMRSWVSLGLVHITNAVLAFLCFLGTFLVQSQPGRYNRARGLTFAMLAYFIIWVSFVPLLANVQVAYQPAVQMGAILFCALGILATFHLPKCYVLLWLPELNTQEFFLGRSPKEASDGNSGSSEATRGHSE
Protein: Large ribosomal subunit protein uL30m (39S ribosomal protein L30, mitochondrial) (L30mt) (MRP-L30) (Q58DV5)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279069, ECO:0000269|PubMed:11551941}.
Interaction partners:
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein mL64
- Large ribosomal subunit protein uL22m
- Uncharacterized protein.
- Small ribosomal subunit protein bS21m
- Large ribosomal subunit protein uL13m
- Small ribosomal subunit protein mS40
Sequence:
MAGILRSIVQRPPGRLQTATKGVEPLVCVDWIRHKFTRSRIPDEVFRPSPEDHEKYGGDPQQPHKLHIVTRIKSTKRRPYWEKDIIKMLGLQKAHTPQVHKNIPSVNAKLKIVKHLIRIKPLKLPQGLPTEEDMSNTCLKSTGELVTRWLLNPADQEAKKC
Protein: Syntaxin-6 (Q63635)
Organism: Rattus norvegicus (Rat)
Function: SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:O43752}; Single-pass type IV membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:30962439}; Single-pass type IV membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:30962439}; Single-pass type IV membrane protein {ECO:0000255}.
Interaction partners:
- Vesicle-associated membrane protein 4
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Syntaxin-16
- Syntaxin-5
- Vesicle-associated membrane protein 8
- Synaptosomal-associated protein 29
- Synaptobrevin homolog YKT6
- Vesicle-associated membrane protein 3
- Syntaxin-12
Sequence:
MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQGPSAATREEIDWTTNELRNNLRSIEWDLEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQIVRDMKDQMSASSVQALAERKNRQALLGDSSSQNWDAGVTDRYGRLDRELQLANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLDDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLTLFLVL
Protein: 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (Heat shock protein 60) (A0A024R3X4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
Protein: Bidirectional sugar transporter SWEET5 (OsSWEET5) (Q6L568)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane (By similarity). Can transport galactose. Prevents growth but promotes senescence. Involved in regulating the crosstalk between sugar and auxin. Regulates negatively the auxin signaling pathway and translocation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24709840}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
Interaction partners:
Sequence:
MVMNPDAVRNVVGIIGNLISFGLFLSPLPTFVTIVKKKDVEEFVPDPYLATFLNCALWVFYGLPFIHPNSILVVTINGTGLLIEIAYLAIYFAYAPKPKRCRMLGVLTVELVFLAAVAAGVLLGAHTYDKRSLIVGTLCVFFGTLMYAAPLTIMKQVIATKSVEYMPFTLSLVSFINGICWTIYAFIRFDILITIPNGMGTLLGAAQLILYFCYYDGSTAKNKGALELPKDGDSSAV
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A1ZBH7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH04846p
- GH16429p
Sequence:
MAAAHSHHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLPQQQQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGMGFGMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSNYRSAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPRTRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMSLSGKSCQLYRHDLVALHSKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPVFEMIITPELEYPIVCTGVRKAMNGCLKLELINMNSASWFHSEDLEYDAMATMVPRRDLLKVVRVHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY
Protein: Mitochondrial distribution and morphology protein 10 (Mitochondrial inheritance component MDM10) (B5VDL3)
Organism: Saccharomyces cerevisiae (strain AWRI1631) (Baker's yeast)
Function: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
Subcellular location: Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03102}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03102}. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids. {ECO:0000255|HAMAP-Rule:MF_03102}.
Interaction partners:
Sequence:
MLPYMDQVLRAFYQSTHWSTQNSYEDITATSRTLLDFRIPSAIHLQISNKSTPNTFNSLDFSTRSRINGSLSYLYSDAQQLENFMRNSTDIPLQDATETYRQLQPNLNFSVSSGNTLSSDNTTVDNDKKLLHDSKFVKKSLYYGRMYYPSSDLEAMIIKRLNPQTQFMLKGVSSFKESLNVLTCYFQRDSHRNLQEWIFSTSDLLCGYRVLHNFLTTPSKFNTSLYNNSSLSLGAEFWLGLVSLSPGCSTTLRYYTHSTNTGRPLTLTLSWNPLFGHISSTYSAKTGTNSTFCAKYDFNLYSIESNLSFGCEFWQKKHHLLETNKNNNDKLEPISDELVDINSNSRATKLLHENVPDLNLAVNDIPSTLDIPVHKQKLLNDLTYAFSSSLRKIDEERSTIEKFDNKINSSIFTSVWKLSTSLRDKTLKLLWEGKWRGFLISAGTELVFTRGFQESLSDDEKNDNAISISATDTENGNIPVFPTKFGIQFQYST
Protein: Putative homeobox-leucine zipper protein ATHB-51 (HD-ZIP protein ATHB-51) (Homeodomain transcription factor ATHB-51) (Q9LZR0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcription factor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- At5g60630
- Arabidopsis thaliana genomic DNA, chromosome 5, P1 clone:MOK16
- Protein LEAFY
- Probable leucine-rich repeat receptor-like protein kinase At5g49770
- Late embryogenesis abundant
- ACT domain-containing protein ACR7
- Probable cysteine protease RD21C
- Beta-glucosidase 15
- Probable transcription factor KAN4
- At2g18850
Sequence:
MEWSTTSNVENVRVAFMPPPWPESSSFNSLHSFNFDPYAGNSYTPGDTQTGPVISVPESEKIMNAYRFPNNNNEMIKKKRLTSGQLASLERSFQEEIKLDSDRKVKLSRELGLQPRQIAVWFQNRRARWKAKQLEQLYDSLRQEYDVVSREKQMLHDEVKKLRALLRDQGLIKKQISAGTIKVSGEEDTVEISSVVVAHPRTENMNANQITGGNQVYGQYNNPMLVASSGWPSYP
Protein: Serpin-ZX (ArathZx) (AtSerpin1) (Serpin-1) (Q9S7T8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inhibits metacaspase-9 (MC9) cysteine protease. Functions through cleavage of its reactive center loop and covalent binding to MC9. Involved in the control of elicitor-stimulated programmed cell death (PCD). During infection by the necrotrophic fungal pathogen Botrytis cinerea, functions to protect cells by limiting the PCD-promoting protease RD21A activity that is released from the ER body or vacuole to the cytoplasm. Involved in the control of water stress-induced cell death by limiting the pro-death protease RD21A activity that is released from the vacuole to the cytoplasm.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:17028019}. Cytoplasm {ECO:0000269|PubMed:23398119}.
Interaction partners:
- Cysteine proteinase RD21A
- Metacaspase-9
- Kunitz trypsin inhibitor 2
- Metacaspase-4
- Metacaspase-1
- Thiol protease aleurain
- Proteasome subunit beta type-6
- Protein disulfide isomerase-like 1-1
- Subtilisin-like protease SBT6.1
- Rapid alkalinization factor 23
Sequence:
MDVRESISLQNQVSMNLAKHVITTVSQNSNVIFSPASINVVLSIIAAGSAGATKDQILSFLKFSSTDQLNSFSSEIVSAVLADGSANGGPKLSVANGAWIDKSLSFKPSFKQLLEDSYKAASNQADFQSKAVEVIAEVNSWAEKETNGLITEVLPEGSADSMTKLIFANALYFKGTWNEKFDESLTQEGEFHLLDGNKVTAPFMTSKKKQYVSAYDGFKVLGLPYLQGQDKRQFSMYFYLPDANNGLSDLLDKIVSTPGFLDNHIPRRQVKVREFKIPKFKFSFGFDASNVLKGLGLTSPFSGEEGLTEMVESPEMGKNLCVSNIFHKACIEVNEEGTEAAAASAGVIKLRGLLMEEDEIDFVADHPFLLVVTENITGVVLFIGQVVDPLH
Protein: Zinc finger protein 385C (Q66K41)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MLLGPASGAPSPLLASLPLPTRPLQPPLDFKHLLAFHFNGAAPLSLFPNFSTMDPVQKAVISHTFGVPSPLKKKLFISCNICHLRFNSANQAEAHYKGHKHARKLKAVEAAKSKQRPHTQAQDGAVVSPIPTLASGAPGEPQSKVPAAPPLGPPLQPPPTPDPTCREPAHSELLDAASSSSSSSCPPCSPEPGREAPGPEPAAAAVGSSMSGEGRSEKGHLYCPTCKVTVNSASQLQAHNTGAKHRWMMEGQRGAPRRSRGRPVSRGGAGHKAKRVTGGRGGRQGPSPAFHCALCQLQVNSETQLKQHMSSRRHKDRLAGKTPKPSSQHSKLQKHAALAVSILKSKLALQKQLTKTLAARFLPSPLPTAATAICALPGPLALRPAPTAATTLFPAPILGPALFRTPAGAVRPATGPIVLAPY
Protein: Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing protein 1) (Palmitoyl protein thioesterase DESI2) (EC 3.1.2.22) (Protein FAM152A) (S-depalmitoylase DESI2) (Q9D291)
Organism: Mus musculus (Mouse)
Function: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22370726}.
Interaction partners:
Sequence:
MGANQLVVLNVYDMYWMNEYTSSIGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIPFLQSCLPKEWLTPAALQSSVSQELQDELEEAEDAAASSAMASAAAGARTGRHTKL
Protein: Probable peptide methionine sulfoxide reductase (Protein-methionine-S-oxide reductase) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Q09859)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized protein C216.04c
- Glutaredoxin-2
- Thioredoxin-1
- Thioredoxin-2, mitochondrial
- Glutathione reductase
- Plasma membrane fusion protein prm1
- Thioredoxin-like protein 1
- DNA polymerase gamma
- Probable phosphoadenosine phosphosulfate reductase
Sequence:
MQIAIIAAGCFWGVQEVYLRKFIPAAAILKTSVGYTGGITADPTYKEVCTNTTNHAEALKIEFDEKLTSYDKIIEFFFAMHDPTTSNQQGNDIGTQYRSAIFTTNPEQATIAKRVMNEVQAKHYPNKKIVTQILPAGKWWDAEDYHQLYLEKNPDGYRCSSHFLRWNVFE
Protein: Conserved domain protein (Q2YLD2)
Organism: Brucella abortus (strain 2308)
Interaction partners:
- Flagellar motor switch protein FliN
Sequence:
MSLLLANVLSTLMALASLAALIVVGRKANETIRLGKVLALRVAAASNGLERAVKAIRNERTDLTDASAKLDARLAETQRVRREMDEAIEELNRLRKALSRDMRQARILAETPPPRQEKTPSAAEQPLPADKNALPVFVRRAVKKATVELAGQA
Protein: Cytochrome P450 2D26 (EC 1.14.14.1) (CYPIID26) (Cytochrome P450-CMF2) (Cytochrome P450-DB2) (Debrisoquine 4-hydroxylase) (P10634)
Organism: Rattus norvegicus (Rat)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Cytochrome P450 7A1
- Cytochrome P450 3A1
- NADPH-dependent 3-keto-steroid reductase Hsd3b5
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
- Cytochrome P450 4F4
- Fructose-bisphosphate aldolase B
- Steroid 17-alpha-hydroxylase/17,20 lyase
Sequence:
MGLLIGDDLWAVVIFTAIFLLLVDLVHRHKFWTAHYPPGPVPLPGLGNLLQVDFENMPYSLYKLRSRYGDVFSLQIAWKPVVVINGLKAVRELLVTYGEDTADRPLLPIYNHLGYGNKSKGVVLAPYGPEWREQRRFSVSTLRDFGVGKKSLEQWVTEEAGHLCDTFAKEAEHPFNPSILLSKAVSNVIASLVYARRFEYEDPFFNRMLKTLKESFGEDTGFMAEVLNAIPILLQIPGLPGKVFPKLNSFIALVDKMLIEHKKSWDPAQPPRDMTDAFLAEMQKAKGNPESSFNDENLRLVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHEEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADIVPTNIPHMTSRDIKFQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVLAGRPRPSTHGVYALPVTPQPYQLCAVAR
Protein: Transducin-like enhancer protein 3-B (Protein groucho-1) (O13168)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional corepressor that binds to a number of transcription factors.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q04726}.
Interaction partners:
- Histone deacetylase 1
- Forkhead box A1
- Transcription factor 7-like 1-A
- E1A-binding protein p300 b.
- Nuclear receptor-interacting protein 1
- Transcription factor GATA-3
- Transcription factor 7-like 2
- Homeobox protein Nkx-2.2a
- Lymphoid enhancer-binding factor 1
- Transcription factor 7.
Sequence:
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSHAAHGPPVQLPPHPSGLQPPGIPPVTGSGSGLLALGALGSQAHLPVKDEKNHHDLEHRERESSTNNSVSPSDSLRASEKHRGSSEYSLDPKKRRVEEKDNMSRYDSDGDKSDDLVVDVSNEDPATPRVSPSHSPPENGLDKARALKKDAPNSPASVASSGSTPSSKAKDHPHNDKSSTPGLKSNTPTPRNDAPTPGTSNTPGLRPHPGKPPGMEALTAPALRTPLSIAPPYGTPFMMGHHPEMNGSLTSPGVYPGLHISPQMSAAAAAAYGRTHMPGFDPHPHMRAPVLPASLTSIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPVSQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASQTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
Protein: Replication factor C subunit 2 (Replication factor C2) (Activator 1 41 kDa subunit) (Q09843)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 2 binds ATP and single-stranded DNA.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Replication factor C subunit 1
- Replication factor C subunit 4
- Replication factor C subunit 3
- Telomere length regulation protein elg1
- Replication factor C subunit 5
- Checkpoint protein rad17
- Proliferating cell nuclear antigen
- Chromosome transmission fidelity protein 18
- Sister chromatid cohesion protein dcc1
- Checkpoint protein hus1
Sequence:
MSFFAPRNKKTEQEAKKSIPWVELYRPKTLDQVSSQESTVQVLKKTLLSNNLPHMLFYGSPGTGKTSTILALSRELFGPQLMKSRVLELNASDERGISIIREKVKSFAKTTVTNKVDGYPCPPFKIIILDEADSMTQDAQAALRRTMESYARITRFCLICNYMTRIIDPLSSRCSKYRFKPLDNENMVKRLEFIAADQAVSMEPGVVNALVECSGGDMRKAITFLQSAANLHQGTPITISSVEELAGAVPYNIIRSLLDTAYTKNVSNIETLSRDVAAEGYSTGIILSQLHDVLLKEETLSSPVKYKIFMKLSEVDKRLNDGADETLQLLDLLSSISVVC
Protein: Uncharacterized protein (Q57XA7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFSTTTGSFCGPSLSQPVSYSLLVLPPKKELRKKGYNMTDINTTSTRVHPLARWQTHVLKHGATYRDALDAVEEANTKHWGFLKARIQFSCGSFESFVRTNPNDPSTLKGVSTYDPNGVFHKETLDCTLKNRSTLLPRLRAIVDGRGHHLSGSTPPARSFHPQVLYKNCPPPVLSQAGYDFTPMSHNAFLLRTNDHPQGVRDVKSDFMKGSCDYRPRAYLRDEVSGGVNSRHCHCAEVYQVGDYTMDLARGAEIDHRNRTVNFEYTKKGTLKSGSNIVGKRHARVPRFPCDHSVKGACADAGMDTRDGGELPLVSGEAVAEGAEQGGATTSPALRSPRRHCGAGNGKGSSDSPVGRSQEREKQVQVLVD