Protein: BEACH domain-containing protein lvsB (Q86JF2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in negative regulation of lysosome biogenesis, by limiting the heterotypic fusion of early endosomes and postlysosomal compartments.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Lysosome {ECO:0000269|PubMed:17488289}. Endosome {ECO:0000269|PubMed:17488289}. Note=Also found in post-lysosome.
Interaction partners:
- AP-3 complex subunit mu
Sequence:
MNRNFNNINNNNNNNNNYHGYQYHQQQQQQNQQQQQQQYNNNVIKYLWNTYTQTVVYQDSLFNLVEFLQFFTLNYYNDTIGDLLFLSNGTLTDITRHLSKHLIEEIGYSCTLLNQQQQTQQTQTQTQSKQQTIPQLSLNNSIPTSFTTTASSTNTTPNAGLKLAEYEIYQYLIGYSTAGEGPLVLAALDILSRQSPNGIPLSFLNFLITILLRILSLPPELLYNNNNNDNNNNINNFSGNNNNNFNNNNHYFNNNHNNHNHHYQHHQLKEKKKNVNKQHFKPIESFFYLQPLPSSLSDMFRDDDYASLSSSYGGGGNLTPLSLSSNHAFSPPLSSLKNSSSNTFTKPSSSTTTTTTTTTQTPTPNSNTDSKQNKDNNNSKNNNKEVSSVVLLGYQILKIVENLVKDKLFLYELVTSDCFSQLLNIFYKLPILSTTASSLPPNSSFSIIYQQLSQIFAQIMSKSCLSSDTIVLIHNFKLIKNLLNIMDKLKEKDEYNMNLIIELNKIILFSIKSSTSITKLLHDDFTKANGYSILLNSMIFISDYGTLKNKIDYIQTTTNLLFIGHRSSYLDKANTKMFEIYLNVFSISTSEETKTELLKCIKGVFYTSLIEESSSSSSLIISSSDNNNNNNNNSDGVNDDKNNNNNNRDNIIFEDVIDMDGNDSYLIFHQFQPFTILFSQFDTLNINNRRMILDMMDVLLTKNRISLNELKEYCNLFKSELPSTVLLVSQHLTELLTKGKVSCDVLGRDLSLTQKLLEFLVNDPTTLRFSSILLQNETELQLCFSILSTNNNNNNSSSKYYSNNIQQQQQQQQQQQQQQKKRHVSRYLVLYMIVTEILSLLLELLVPPSIQTIFIQECQGLKLLYPMLLDEYLIQPALKVIASIAIGGLQLESRIIPDLIMELQNNGGGATNLDSKVLTMRKNIFSSMCYIFHNNPNSKNSFRNFQGFTWSLSILDGISRYLISIDNNNNNSSNNNSNDNLNDFKESLDHSCNGVLNSNNSSNNSNLNGGIGNEIKKSSFNEIFYFLKVLIDMLSAAMKNNSINQEYFRKEIIIISRSLKQCKYMEGIHAISLCDSLLNMAITGSWPPSCENHSLEEGSLFSLYSPITSFFPINTTLSKNFDISFILKFEKKEQMEQQLKQQILLNSNNNINNGNGGSISPSSIINNMNSPGGGSSSSNDSLKSPTRRSRSYTNDFHLDKSSRIPHPPDFNNNNDTMNYDYNFQDDYIESLNSKSSSSFSLDLASVTGDSEIVYYGGSTTSRMIHSPGLPSSSLQALSSNSTKLPEKSSLQLAQERYICCQSCRDTLTLEMPEIFKLIIELMSSDDDISQTEIKSSCYIIRELIFLTNCSLANQKRLSSLLIDIITHFKPLLLSIILYQKQQQQQQQQQQQSNSNSNSNSTIILKKKINNETSTKLKPLLLDLIQTLAGHNLTLIEFRKYFELLKVKDSNNQFIYPIDLLNLLLKISSNRDNIPLYYAELSKHGLEYIDFPSWGERTWPPTKGFGISFWFRYSLPCLNINKSPIYLLSIEGSIGNSSTKSCECQLILENGKLVYKIYHFSGICETYHFSDHKFEPDQFYHISISHSSLLSTTTTTATTANTTTNSTTASTTTTTTNSTTAVSSTTNSISTTAAVAAITTSDGNSGISRENSLGGRDSIGSNSSSSSSSSNSGVSSGSSTNLNKKSPVKLYVNGCLRGQILANYPKSNSMTLYIRFGGVNAASSVISNNQDVQSFNVNNSWNLGNAYFFEEVPLDKEIFYLYLLGPNHFRGLKVDLSAVDSIQPSLDKVSNLHPFLIDHLLNPTVQPLLSLHEKIMYIFTAKCLYVTTHRITNKTESVTHASALPQLSTILFQQQQLQQQQLQQQITNSTTSILNELNLSNSINLIRRGSENSLITSSSSSSLSLSLSSNTNNNNNNNTRSSLERSISGNFLQSPSSSNNNLRERSINNNNNNNNNSNNNNNNNSISSSTSSLSSSVISLVAGAMAVPSPPSPNKLGSGINGSSILNASLTTLSISTNNNSNNSNNSNSNNNNNNNNTNYNSNSLNNSLNHQALSLLHTGLPIALPRGVISQIGVKDAIMNSGGVSVIIYLIAMAEDKEYQRSGLKLLQSIIHNSQLNLKDMKEISGYQLVSFLIRKKNWVLDDQLLSILFSFVGIQSTRTSIHYVDGVVQDVLALKHFLLERSIWRRASLIDQKKLFESLEKLVNVLHENHEFNIIKFRQAGAYETILKMCREDDLPLELLSTLTKILRSITTNKSNKLKDDLQLILSWLLETMPKQQIFKKYNSFNGLNSTNNSNNNNNNPISLFRKGRKTLLQVQFDNHQLYLQQQQQQNLIPQVNSNNNNEESNNGIEGIIRINILNLLLDILSKTELSVVEDFHSICSLETIFGLLTCESMVSRVMFLKIIDIFLHSQMIFGHFQKMKGFHLLGHQLLPFETSEKIFGVLFCILFGKPSNSDILEGLSMRMYFLSHLSDAEMKYPGAIVTILIILCNSNSTTQHNVIKMIHNIFLQNDQFKQSLLDNELIPRLVDILSSNYQRRGSSSSSTNSTTNNNNNNSSTTTTSNNNNNNNENNNEDDWVAEESILSLLKEIALYGAKSQDGSAALLRDILVVLHLNTRMDYDYICCLQRRVLFDVISFFNDNIHSFSSIDSLVSSFEKLCVLTIHTLSYQEKLLLTNGTGTGGGTGGSGGGLLTKKSFRSNLFSPSRSKEKEKEKEKEKEKEKEKEKERERERETTNVTSDSDNILSANDIFYGDQSNEESSTTDSDSTSDNNNNNNRNSYSGRNIRGNGINNNNNKNKFIPIWIKEGNLLDQEEFIRSLLKVLSKSKIPQSNTTYRNLFSTQYSARSLLCKFIFILLTFDEFKDYYLMVLQELSNMVPSLSNTPISSSPIISPINNNNNYYNTNSNTNSNSSTPSLFSITSNNNNNNNNNNNNNNNNNNNNNTNSTNQTITDTTLSPASSNVSISNQSTPISNNNNNNNSSGGGSGGSNINIPPTINISDSNSNSNEQQGISSVLSEIIMEEDFILVLLHITHKFLQSGNDYEIQRNSFRLWVSIIQHCSQVDYVKKAFDTTTTSLAVLSSSQEIRDLLIRYQQIYVENEFKKWEEKFNQSKKEWKLQYFETQKNKQSMITKNQDITKSTKKLSDSLIQLKSEYEKSNYQYLIENRESKRFFQSQWKLLIKKVTHEKAIWSPNYEISNSSSTNITTTTTTTTTAKKWKLDPTEGLNRMRMRLKVISDNTSNSHIPLIPDLSTPSTPPSPQNTKDQLLFNFNNYNNNNNNNNNNGLNAPPLHGSLDYSSFDNLKLGEKVNEVFKCSCISPFYQRDGELLIGDQNVYFLDELLTSADRKKTTASTVGGSNNNNNNNNNNNNNNNNNNNNSNDTTSSINSTTATNTNTTNTTTTNTTTTTTTTNGLSNIVKPPQRGKHITWSYDDIIEIHKRRHVLKNNAIEIFLGSGVPHKTYLFAFNKPSDRDIVYDLIMSKPLPNRVDYAAEVHGNILKMSITKKWQSGLISNFEYLMHLNTLAGRSFNDLTQYPIFPFILRDYESEVLDLENPNTFRDFTKPMGAQDPKRLEKFIEKYNDLLEMNEKPYHYGSHYSNIGSVLHFLVRLQPFTSYFIDFQGGRFDVPDRAFHSIAQSWNLSSSISNSDVKELIPEFFYLSDFLVNSNKFFMGIKQNGVKVDDVILPPWAHNDPRLFIKKHNEALECKYVSENLHHWIDLLFGYKQQGEAAVKAHNMFFPLTYEGAVDIDSIEDQLNRDAAVAQIHSYGQTPKQIFTKPHPKKNWSKTIRLTQDSIFTKPERLTSYIMFQYRSPIGSITIANDSSPIHLTPQRILFFPDNNKSISWGHWDQNLRVNSIDTGKVLSIIEVLNDDIICGDITKNGRLFVTGGTAGTVKVWKRCNNDGTIMTRKERGDNLSLWSTLYGHTNSILCVTVSQEYSIIVSGSKDSNCIIWDLNRLTYINSLQHDHPVTCVQVSPTFGYIATFETNIYNKQNNNSGGGGSKNDNSINGSGCLRLWSINGTLLAKQNFVNDRVNCMIFTSTIQGVNTNLLITGMESGTIILWNAWNLQKIRTLVSKSTITALAVSKDNTQLISGDINGLIECLSSRSFDGYSSIVLG