wanglab/gogpt-training-data huggingface dataset:
Protein: Pregnancy-associated plasma protein A, pappalysin 1a precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A paralog a, Papp-aa, pappalysin 1a) (M1XYM1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MKVWTFLQCLAILLVLLCVGSECGTVLRNTRSKRELVKIREAKLVFPGACGTRLPRGKRSLPGMDRRIPRQRRRSSPTEDASSSRGKAVYFTGRGDQLRLKPGVEIPKGNFTLQMWVKAEGGQRSPTVIAGLFDKCFYASSDRGWLLGIKSVSEQGNRDPRFFFSLKTDRAHKVASIHSNARYLPNHWVHVAVTYNGLFMKLYINGAQTAVSREQSGDVFSPLTKKCKVLMVGGNALNHNYRGSVERLGLWRQALSQRQIMRDMHGREDPEDLVDLVIRETFEHPARKWLAVKDGSFPIPDDGPRAGLGSLDTTLEPPACGQTVCDNTEVVRNYNHFWSFRQPKTVRYRVVNVFDDFQRKPTVTDQQIHLQHQHLNEAFSMYNISWELTVHNVSNSSLYNRLVLANCDISKVGDDDCDPECNHTLTGFDAGFCKPRPEKHRTECPERKQGNGVCDPECNCENYNYDNGDCCNSSVTDVTKTCFNPTSHLRAYLDVKELKEILKLDGSTHLNIFFANSSDEDLAGVATWPWDKDALAHLGGIVLNPSFYGTFGHTHTMIHEIGHSLGLYHVFRGISEIESCNDACLETEPSLETGDLCADTNPTPKYKLCKDPEPGNETCGNRNFVHTPFNNYMSYAEDDCTDSFTLNQVARMHCYLDLIYQTWQPNYRPPPVPMAPQVVEQDHGSISIEWFPPISGHFYDREVGSVCDKCAEGRILLQYASNSSSPRPCSPSGHWSPREAEGPPDVEQACEPSVHTWSPHNGMDLGLVPPPCPLQGCMLQLEFAYAVVPDSLTVWVTFSSQDETVLPAIHNIILLTVGGNNLSLGPSNLFCDTPLTIKLDVQEKVYGVQFYTMEQHLEIDATLLTSKPDCPLCGDCEPLHFRLLRQPPFSNSKQGIMLSDSTRRYTDRDVEYGGIYTYQVQTVSSRSESEPSPPFTHRIGAPYCGDGFIQRSLGEECDDLNAMNGDGCSSHCKKEPFFNCIDEPSMCYYYDGDGVCEDFERETSVKDCGLYTPNGFLDQWATVVEVSHEERLYCPADVAAGYPAITKTCQSKVFDLSDGVSQYAWFPCREAHSVPWYPPYWLKAYFSHPMVAAAVIIHLAADGTSYMDQTQCNITVQLIDTKEAIHSLGDWRLSCRTNPLVIPVSHDLSMAFYHTKAILLMFRSEFVAISGVGLRSFQFFDPITISGCQSNEIYNPMGQSCVHYSCEAIDCQEPLIRNAEVECSDGGYFNGARCTVVCNCGYVLQIHRDDDIIKSQTDSSVTITCADRKWNKQVSCEPVDCGLPDKYHVHPTIFDFPEGTTYGKKSTFQCKEPAQLVGFNNTLTCMEDGLWSFPEALCELRCPVPPPVPNAVLQTKRCNDTGLKVGTLCKYKCKPGYHVANKPKRRAFKRQCTEDGRWLEGSCEAVTCPAPPSVYYGMYQCTDGFRFDSTCWIDCDGANHTLTQPPPCKQGAGSNVIRCRKDGNWTGSFRLCPQLKGQCSLPQNLHPSIRISCKKGHGIGEECELSCRDSNNDVVILPGNMTTSSIMRHHWMNPPKVKHIVCTMGLKWYPHPEVLHCIKGCEPFMGDNYCDAINNRAYCNYDGGDCCHSTVKTKKVIPFPMSCDIRRECACRDPNALENRKDEHLHSLG
Protein: Zinc finger protein egl-43 (Egg-laying defective protein 43) (Q22024)
Organism: Caenorhabditis elegans
Function: Probable transcription factor, required for migration of the hermaphrodite-specific motor neurons (HSNs) from the tail to the gonad primordium during HSN cell differentiation. Required for phasmid neuron development. Required to specify the pi-cell fate of ventral uterine precursor cell (VU) cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:10049362}.
Interaction partners:
- Transcription factor fos-1
- Nuclear hormone receptor family member nhr-67
- Matrix metalloproteinase-A
- Protein lin-12
- Ig-like domain-containing protein
- Cadherin-3
Sequence:
MSIDTDFLTSVEVKEDELHGNVLIAVTQIALGRTIGVIDKATPNDSNALLILNLIKEADDGEDANICMRQEDRKTFLQTSKIINIGERLLLQRLSEEECDEEDQDDLENLILLKDEDRPDSTQSCTKSSSEDSNLNGFEEYIREHGELVPGQTPPDGSHKCGVCPKSFSSASGLKQHSHIHCSLKPFRCHLCPKSYTQFSNLCRHRRVHSDGWTCPTCQSQMPSQAALTKHRPVCEMTALYKPLMAQLAGLSGAGGLGSVPYWPHILQMATQAPHFPLAFLAANPEAYKLMQQTTCASPDAECSSGHASESSPTTTEPVDLTATPKPPSTSEMETTSKSDDGEDRDSIGDSGNDDDDDSEAGVLDESSTTTSTKKRPTSHTISDILAAPQLGAQALNSTFLGMLQRSLNYNPAVPSPHSFLRAMSGAKASSSPSSSSGSGKDRYTCKFCQKVFPRSANLTRHLRTHTGEQPYKCQYCERSFSISSNLQRHVRNIHNKPNTSLTPHNHHRQRSLHNSTSTSTTTTTVHHPLLHLPGTSVPVPKV
Protein: Nebulette (Actin-binding Z-disk protein) (O76041)
Organism: Homo sapiens (Human)
Function: Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion.
Subcellular location: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15004028}.
Interaction partners:
- Myopalladin
- Titin
- Xin actin-binding repeat-containing protein 2
- Alpha-actinin-2
- Heart- and neural crest derivatives-expressed protein 2
- Zyxin
Sequence:
MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEISEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN
Protein: Mitochondrial inner membrane magnesium transporter MFM1 (MRS2 function modulating factor 1) (Q02783)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11254124, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:19756047}; Multi-pass membrane protein {ECO:0000269|PubMed:11254124, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:19756047}.
Interaction partners:
- Magnesium transporter ALR1
- Manganese resistance protein MNR2
- Required for respiratory growth protein 1
- Mitochondrial distribution and morphology protein 38
Sequence:
MRAFPRVLPFRHQRSYNNILLRTVRLFGSSLSSFDFSRQMPKVDPDNTAAMLLQKNLIQRNNMLYGYGSGTIRCTLLDSTGRAKSPLVEIKREDLVSKHGLLPRDLRKIEKSRKNDLVPSLLVRENSILISLLTVKALIKPDMVIIFDSAGSGITLNSEAHKDFINDMKLRLKNQETSELNSDPLPYEFRALETIFISALSNLTSEMKVLLTICKGVLQDLEFSITRDKLRFLLGQNKKLSSFNKKAVLVKDMLDDLLEQDDMLCDMYLTDKKAGKIRVQDDHTEIEMLLETYHNYVDEIVQKSESAISDVKTTEEIINIILDSNRNELMLLGIRYAIGMLSLGGALFLGSIYGMNLESFIEESNYAYLTVTILGLISTVWLYAKGIRHLHKLQRMTLLSKIKTDSVHELLKK
Protein: Ras-related protein Rab-7a (B5X431)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MASRKKVLLKVIILGDSGVGKTSLMNQYVNKRFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVTAPNTFKTLDSWRDEFLIQASPRDPDNFPFVVLGNKIDLENRQVTTKRAQAWCASKNNIPYFETSAKEAINVDQAFQTIARNALKQESEVETYDFPDQIKLRDERPSSSSDGCSC
Protein: RNA-binding protein, putative (Q389P7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- REH2-associated factor 1
- Mitochondrial RNA binding complex 1 subunit
Sequence:
MKRTPVRVLNATVAFLQGWGGGSSGGGWGSDDGPGNGSGGGGSGGRGGWGSGGGGGGGWGSGGGGNGGWGSGGGGGGGWGSGGGGRGSGGGSNGGWGSGRGGSAHGFSNPWNDGDAGWRGAATGARANRGRGGFRRGRGGADDGVWGQPNVVDEEAWTAAPPSFNPPVRRVDPLTLTAVEVEIDGIKKLVGQRVQVSGLSDETTWHTLKDHLRQAGEVTFCKVFSGGRAVVEFVTPEDAARAITELQASELEGATLFLREDREDTVLVNTRRKIREVRDAQLRARKEEMEKKRREQAIAEGDCSAPAPPAEVAGDASQKV
Protein: Small ribosomal subunit protein mS26 (28S ribosomal protein S26, mitochondrial) (MRP-S26) (S26mt) (Q9VVN2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q3SZ86}.
Interaction partners:
- FI07234p
- GH07821p
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS3m
- Small ribosomal subunit protein bS16m
- LD06441p
- Small ribosomal subunit protein mS25
- Small ribosomal subunit protein uS2m
Sequence:
MLRAGCQLLTQSTLPTGKTVGNSFALEFVRWRRKPRWLPVAKSKMFRVPERKKQSEEERTELMRLHNQYKTQLRSVRQFLREEVVRHEETSTADHIVLTPEQEEAEFQKCLDANAAWNAAIAKERDQRLAKKREEKVAYIQERLEAQQLREEERKEQANQRVLLEIERSKNYITRENLDAAIETALANPVDHNFAIDMAGNLYHGRSTSQLPDATPEPNQQVLSN
Protein: Zinc finger protein GLI1 (GLI) (P55878)
Organism: Gallus gallus (Chicken)
Function: Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity). May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P08151}. Nucleus {ECO:0000250|UniProtKB:P08151}.
Interaction partners:
- Suppressor of fused homolog
- Protein smoothened
- Sonic hedgehog protein
- Protein patched homolog 1
- Kinesin family member 7
- Speckle type BTB/POZ protein
- Kinesin-like protein
- Speckle type BTB/POZ protein like
- Zinc finger protein GLI2
- cAMP-dependent protein kinase
Sequence:
MFNPVTPQARPYAEHCCPRPLHGASAGTPGLQGLDFPVCHQPNLASSHHGYGLVPGTEHPGGAADGSRFSTPRGAGKLGKKRALSISPLSDSSVDLQTVIRTSPNSLVAFINSRCASAGGSYGHLSISTISPSLGYQNPPGQQKGQGQLFSHTPPLPPCSSHETLSSRPGLLHPTPARGTIKHCQQLKLERSLSSPLTAKYPEEKSEGDISSPASTGTQDPLLGMLSVRDDLEKEDGKPESETIYETNCYWDGCAKEFDTQEQLVHHINNEHIHGEKKEFVCHWAACSREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKHRGSVVPGHALPASAAPQDMKQEKNTNGPAEIRKDDGKLLVPDLVSKPQPSPGGQSSCSSDRSPLGSTTNNDSGVEMTGNTGGSYEDLVHAGGCGARGSHGHLGADGLQKLENLRIDKLKQMRKPSTKGLNLPAIPEPVCRRCVRVCV
Protein: Zinc finger protein 513 (Q8N8E2)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator that plays a role in retinal development and maintenance.
Subcellular location: Nucleus {ECO:0000269|PubMed:20797688}.
Interaction partners:
- Interphotoreceptor matrix proteoglycan 2
- Photoreceptor disk component PRCD
- Photoreceptor cilium actin regulator
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
- Ceramide kinase-like protein
- Protein eyes shut homolog
- U4/U6 small nuclear ribonucleoprotein Prp31
- Fascin-2
- Guanylyl cyclase-activating protein 2
- U4/U6 small nuclear ribonucleoprotein Prp3
Sequence:
MPRRKQSHPQPVKCEGVKVDTEDSLDEGPGALVLESDLLLGQDLEFEEEEEEEEGDGNSDQLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVEEPARGPGEARGERPGPACQLCGGPTGEGPCCGAGGPGGGPLLPPRLLYSCRLCTFVSHYSSHLKRHMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHAGPPTPPCPTCGFRCCTPRPARPPSPTEQEGAVPRRPEDALLLPDLSLHVPPGGASFLPDCGQLRGEGEGLCGTGSEPLPELLFPWTCRGCGQELEEGEGSRLGAAMCGRCMRGEAGGGASGGPQGPSDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYTTGHWDNYKRHQKVHGHGGAGGPGLSASEGWAPPHSPPSVLSSRGPPALGTAGSRAVHTDSS
Protein: Major viral transcription factor (155 kDa immediate-early protein) (P17473)
Organism: Equine herpesvirus 1 (strain Kentucky A) (EHV-1) (Equine abortion virus)
Function: This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis.
Subcellular location: Host nucleus.
Interaction partners:
Sequence:
MASQRSDFAPDLYDFIESNDFGEDPLIRAASAAEEGFTQPAAPDLLYGSQNMFGVDDAPLSTPVVVIPPPSPAPEPRGGKAKRSPSAAGSGGPPTPAAAAQPASPAPSPAPGLAAMLKMVHSSVAPGNGRRATGSSSPGGGDAADPVALDSDTETCPGSPQPEFPSSASPGGGSPAPRVRSISISSSSSSSSSMDEDDQADGAGASSSSSSSSDDSDSDEGGEEETPRPRHSQNAAKTPSAAGSPGPSSGGDRPAAGAATPKSCRSGAASPGAPAPAPASAPAPSRPGGGLLPPGARILEYLEGVREANLAKTLERPEPPAGMASPPGRSPHRLPKDQRPKSALAGASKRKRANPRPRPQTQTQAPAEEAPQTAVWDLLDMNSSQATGAAAAAASAPAAASCAPGVYQREPLLTPSGDPWPGSDPPPMGRVRYGGTGDSRDGLWDDPEIVLAASRYAEAQAPVPVFVPEMGDSTKQYNALVRMVFESREAMSWLQNSKLSGQDQNLAQFCQKFIHAPRGHGSFITGSVANPLPHIGDAMAAGNALWALPHAAASVAMSRRYDRTQKSFILQSLRRAYADMAYPRDEAGRPDSLAAVAGCPAQAAAAAASQQQPEAPAPSVRVREAYTRVCAALGPRRKAAAAAAAPGTRAPRPSAFRLRELGDACVLACQAVFEALLRLRGGASAVPGLDPSEIPSPACPPEALCSNPAGLETAALSLYELRDLVERARLLGDSDPTHRLGSDELRLAVRAVLVVARTVAPLVRYNAEGARARASAWTVTQAVFSIPSLVGGMLGEAVSLLAPPTRSQQPSSSSPGGEPFSGSAAAEGSLQTLPPLWPTVPGKQSATVPSSHSQSPQHSQSGGGAGATTATCCRATQTNARSRGQQHQPQKARSPQAAASPAHLSQEAMPGSSSDDRAIHGRPRGKSGKRRSEPLEPAAQAGASASFSSSARGYDPSGPVDSPPAPKRRVATPGHQAPRALGPMPAEGPDRRGGFRRVPRGDCHTPRPSDAACAAYCPPELVAELIDNQLFPEAWRPALTFDPQALATIAARCSGPPARDGARLGELAASGPLRRRAAWMHQIPDPEDVKVVVLYSPLQDEDLLGGLPASRPGGSRREPLWSDLKGGLSALLAALGNRILTKRSHAWAGNWTGAPDVSALNAQGVLLLSTGDLAFTGCVEYLCLRLGSARRKLLVLDAVSTEDWPQDGPAISQYHIYMRAALTPRVACAVRWPGERHLSRAVLTSSTLFGPGLFARAEAAFARLYPDSAPLRLCRSSNVAYTVDTRAGERTRVPLAPREYRQRVLPDYDGCKDMRAQAEGLGFHDPDFEEGAAQSHRAANRWGLGAWLRPVYLACGRRGAGAVEPSELLIPELLSEFCRVALLEPDAEAEPLVLPITEAPRRRAPRVDWEPGFGSRSTSVLHMGATELCLPEPDDELEIDGAGDVELVVEHPGPSPGVAQALRRAPIKIEVVSDDEDGGDWCNPYLS
Protein: Polygalacturonase QRT2 (AtQRT2) (PG QRT2) (EC 3.2.1.15) (Pectinase QRT2) (Protein QUARTET 2) (Q9SFB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Polygalacturonase required for cell type-specific pectin degradation to separate microspores. Involved in anther dehiscence and floral organ abscission.
Subcellular location: Secreted, cell wall {ECO:0000250}.
Interaction partners:
- Pectinesterase QRT1
- Polygalacturonase QRT3
- Polygalacturonase 1 beta-like protein 2
- Probable pectinesterase 48
- Protein trichome birefringence-like 8
- Probable pectinesterase 55
- Protein RIK
- Protein trichome birefringence-like 16
- Protein trichome birefringence-like 9
- Protein trichome birefringence-like 18
Sequence:
MYEKIIILSVFLLTFLPSCFSSYPFNHRDDLFMSSNVYYETNRQHQHGHNTRNSHLKNRHGYAPRSSPRSFNVNTFGAKANGNDDSKAFMKAWEAACSSTGIVYIVAPKNRDYMLKAVTFSGPCKSSLIIFKIYGRIEAWENPSDYKERRHWIVFENVNNLRVEGGGRIDGNGHIWWPKSCKINPQLPCLGAPTAVTFVECNNLRVSNIRLENAQQMHLTFQDCKNVKALNLMVTSPADSPNTDGIHVSGTQNILIQDSIVRTGDDCISIVSGSENVRATGITCGPGHGISIGSLGEDNSEAYVSNVVVNKATLIGTTNGVRIKTWQGGHGMAKNIIFQDIIMKNVTNPIIINQDYCDRVEACPEQKSAVQVSNVLYKNIQGTSSRPIAVKFVCSKNIPCRGISMQNVKLVDQTQQDVSKASCSNVKLDTRGNVSPLCT
Protein: Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (MAC25 protein) (Q61581)
Organism: Mus musculus (Mouse)
Function: Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q16270}.
Interaction partners:
- Insulin-like growth factor 1
- Insulin-1
- Insulin-2
- Insulin-like growth factor 2
- Metalloproteinase inhibitor 2
- Insulin-like growth factor-binding protein 5
Sequence:
MERPPRALLLGAAGLLLLLLPLSSSSSSDACGPCVPASCPALPRLGCPLGETRDACGCCPVCARGEGEPCGGGAAGRGHCAPGMECVKSRKRRKGKAGAAAGGPATLAVCVCKSRYPVCGSNGITYPSGCQLRAASLRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAKVFLSCEVIGIPTPVLIWNKVKRDHSGVQRTELLPGDRENLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASAAAKITVVDALHEIPLKKGEGAQL
Protein: Ras-related protein RABE1e (AtRABE1e) (Ras-related protein Rab8E) (AtRab8E) (Q9SF91)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in membrane trafficking from the Golgi to the plasma membrane.
Subcellular location: Golgi apparatus membrane. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta 1
- Ran-binding protein 1 homolog b
- Rab escort protein 1
- Guanosine nucleotide diphosphate dissociation inhibitor 2
Sequence:
MAVAPARARSDYDYLIKLLLIGDSGVGKSCLLLRFSDDTFTTSFITTIGIDFKIRTVELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDESSFNNIRNWMKNIEQHASDSVNKILVGNKADMDESKRAVPTSKGQALADEYGIKFFETSAKTNQNVEQVFLSIAKDIKQRLTESDTKAEPQGIKITKQDANKASSSSTNEKSACCSYV
Protein: Uncharacterized protein (O25709)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- Flagellar secretion chaperone FliS
- Flagellin B
Sequence:
MDILKTLQKHLGDVETSDFTTNAIEKSQQIAKFSRDMKNINESVGALQVLQIACKKLFNKSMGLEDKDALQASIIKQELREIVENCQFLASPLFDTQLNIAINDEIFSMIVVNPLDLLENVGEFQAYLEEKLNEIKELLGYLSESLSNPKAFMPSFSNQSLKDLLSDNLRA
Protein: Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Subtilisin-like proprotein convertase 7) (SPC7) (Subtilisin/kexin-like protease PC7) (Q61139)
Organism: Mus musculus (Mouse)
Function: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Seems to be localized intracellularly to the trans Golgi network. {ECO:0000250}.
Interaction partners:
Sequence:
MPKGRQKVPHLDAHLGLPICLWLELAIFFLVPQVMGLSEAGGLDILGTGGLSWAVHLDSLEGERKEESLTQQADAVAQAAGLVNAGRIGELQGHYLFVQPTGHRQAMEVEAMRQQAEAVLARHEAVRWHSEQTLLKRAKRSIHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPHPDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTAIQYEDHHADWLTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAVPRSPHSLEVLWNVSRTDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNAWTFSTVRCWGERARGVYRLVIRDVGDEPLQMGILQQWQLTLYGSMWSPVDIKDRQSLLESAMSGKYLHDGFTLPCPPGLKIPEEDGYTITPNTLKTLVLVGCFSVFWTIYYMLEVCLSQRNKASTHGCRKGCCPWAPRRQNSKDAGTALESMPLCSSKDLDGVDSEHGDCTTASSFLAPELDCPPHQPPDLLQGKSGQIC
Protein: Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114) (O18235)
Organism: Caenorhabditis elegans
Subcellular location: Mitochondrion inner membrane {ECO:0000256|HAMAP-Rule:MF_03190}; Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_03190}; Matrix side {ECO:0000256|HAMAP-Rule:MF_03190}.
Interaction partners:
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial
- Ubiquinone biosynthesis protein coq-4, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Atypical kinase coq-8, mitochondrial
- All trans-polyprenyl-diphosphate synthase PDSS1
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Kynurenine 3-monooxygenase
- FAD-binding domain-containing protein
Sequence:
MIPSRSARIIAKLQRLHSTTSAASVSSIDVKEVEKFGDLSAEWADELGPFHALHSLNRIRVPWIVDNVRKSDQKAPPRLVDVGSGGGLLSIPLARSGFDVTGIDATKQAVEAANQSLTAKPLQIAGISKRLRFEHTSVEDFCQKPHNKSAYDAVVASEIVEHVADLPGFIGCLAELARPGAPLFITTINRTWLSKLAAIWLAENVLKIVPPGVHDWEKFITPAELTSHLEKAGCRVTAVHGLMFHPVGNHWTWIESTQCNYGILAVKN
Protein: Cardiotrophin-2 (CT-2) (Neuropoietin) (Np) (P83714)
Organism: Mus musculus (Mouse)
Function: Increases the platelet count associated with splenomegaly. May have an important role in neuronal precursor development and maturation.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Leukemia inhibitory factor receptor
- Interleukin-6 receptor subunit beta
- Ciliary neurotrophic factor receptor subunit alpha
- Cardiotrophin-1
- Oncostatin-M-specific receptor subunit beta
- Interleukin-6 receptor subunit alpha
- Interleukin-27 receptor subunit alpha
- Ciliary neurotrophic factor
Sequence:
MYCLLATPLCLLSLLLPPLSPAAPISPSEPIGQAYSLALYMQKNTSALLQTYLQHQGSPFSDPGFSAPELQLSTLPSAAVSFKTWHAMEDAERLSRAQGAFLALTQHLQLVGDDQSYLNPGSPILLAQLGAARLRAQGLLGNMAAIMTALGLPIPPEEDTLGFVPFGASAFERKCRGYIVTREYGHWTDRAVRDLALLKAKYSA
Protein: ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) (P48048)
Organism: Homo sapiens (Human)
Function: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12684516, ECO:0000269|PubMed:16357011}; Multi-pass membrane protein {ECO:0000255}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000269|PubMed:12684516}.
Interaction partners:
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Serine/threonine-protein kinase Sgk1
- Serine/threonine-protein kinase WNK4
- Solute carrier family 12 member 3
- Chloride channel protein ClC-Kb
- Serine/threonine-protein kinase WNK1
- Cystic fibrosis transmembrane conductance regulator
- Barttin
- Extracellular calcium-sensing receptor
- Serine/threonine-protein kinase WNK3
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
Protein: Low-affinity phosphate transporter PHO91 (P27514)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:17804816}; Multi-pass membrane protein {ECO:0000269|PubMed:17804816}.
Interaction partners:
- Inorganic phosphate transporter PHO84
- Phosphate permease PHO89
- Phosphate system positive regulatory protein PHO81
- Phosphate system positive regulatory protein PHO4
- Tryptophan synthase
- Cyclin-dependent protein kinase PHO85
- PHO85 cyclin PHO80
- Vacuolar transporter chaperone 3 complex subunit 3
- Vacuolar transporter chaperone complex subunit 4
- Protein SYG1
Sequence:
MKFSHSLQFNSVPEWSTKYLAYSQLKKLIYSLQKDKLYSNNKHHVVEPHDANDENLPLLADASPDDQFYISKFVAALNQELKKIDKFYISQETGLIANYNELKDDVMELENTNKATQLFNQQQQHQLQSVARNRKSKSQQRQRRFSSVSSTDSNPSLTDMSIDSAPVIHTQVSNTTNNGNSMQNLASASVSLSNSNPVYLSPFTQHRLSLKKRLISIYTQLSELKDFIELNQTGFSKICKKFDKSLNTNLKQNYLNYIKFHSHVFNPATINRIQHHITETILTYASLNKGTRRPSNTFNLDADRINNDENSSGNEEDEDGNRQEVLDFQDAERELSSHLRDHVVWERNTVWKDMMNLERKYQSAKTDNKKFSKLSSSQLRPNANITESMAMSSGGAGIIAPSTDSLTFRELMHLPPKQWLQFIMGQTSLLKFLLITSCFIALLTFNLTPFTQDSLQKNCFAILIYASLLWATETIPLFVTSLMIPLLIVVFPVIKDPITSQPMSPRDSSQFILSTMWSSVIMLLLGGFTLAAALSKYNIAKVLSTHILASAGTNPHFILLTNMFVALFVSMWVSNVAAPVLCYSIVQPLLRTLPRNCSYAKALILGIALASNIGGMSSPIASPQNIFSIGIMDPSPSWAEWFMIALPVCFICVMAIWVLLIITFPPEPNVKILQLHPSRDPFTLKQWFVTLVCIITIVLWCLSNQISGIFGEMGIISIIPIVVFFGTGLLTSDDFNNFMWTIVVLAMGGTTLGKAVSSSGLLSTMAQLIKAQVEHEPIFIIVLIFGLVILVMATFVSHTVAAMIIVPLMSEIGSNLPSGDHSRLLIVIAALLCSSAMGLPTSGFPNVTAISMIDEVGDRYLTVGTFITRGVPASLLSYAAIVTVGYGILKVMGF
Protein: Histidine N-alpha-methyltransferase (EC 2.1.1.44) (Histidine trimethyltransferase) (A0R5M8)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate.
Interaction partners:
- Hercynine oxygenase
- Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase
- Glutamate--cysteine ligase EgtA
- Probable hercynylcysteine sulfoxide lyase
- Sulfatase-modifying factor 1
- Sulfatase-modifying factor 1
- Histidine ammonia-lyase
- Histidinol dehydrogenase
- DUF58 domain-containing protein
- Phosphoribosylamine--glycine ligase
Sequence:
MTLSLANYLAADSAAEALRRDVRAGLTAAPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRTEAQILRTRSAEIIAAAGADTLVELGSGTSEKTRMLLDAMRDAELLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPHVGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGRLVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIEMWLRARTAQHVRVAALDLEVDFAAGEEMLTEVSCKFRPENVVAELAEAGLRQTHWWTDPAGDFGLSLAVR
Protein: Squalene synthase (SQS) (SS) (EC 2.5.1.21) (A0A1W2PQ47)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAAACGTKAMALFKRTLVLSPAAAPRGPGAGTAPRGCCLPPAAWPCKDWPRGEGGRLWSRLPQSHSHSHSHSHSHSCSSTSPTAVCVVCPQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH