wanglab/gogpt-training-data huggingface dataset:
Protein: 2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) (Enoyl-CoA hydratase) (P76082)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reversible conversion of enzymatically produced 2,3-dehydroadipyl-CoA into 3-hydroxyadipyl-CoA.
Interaction partners:
- 1,2-epoxyphenylacetyl-CoA isomerase
- 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase
- 3-hydroxyadipyl-CoA dehydrogenase
- Putative 1,2-phenylacetyl-CoA epoxidase, subunit D
- 1,2-phenylacetyl-CoA epoxidase, subunit A
- Acyl-coenzyme A dehydrogenase
- 1,2-phenylacetyl-CoA epoxidase, subunit C
- 1,2-phenylacetyl-CoA epoxidase, subunit B
- Bifunctional protein PaaZ
- Acyl-coenzyme A thioesterase PaaI
Sequence:
MSELIVSRQQRVLLLTLNRPAARNALNNALLMQLVNELEAAATDTSISVCVITGNARFFAAGADLNEMAEKDLAATLNDTRPQLWARLQAFNKPLIAAVNGYALGAGCELALLCDVVVAGENARFGLPEITLGIMPGAGGTQRLIRSVGKSLASKMVLSGESITAQQAQQAGLVSDVFPSDLTLEYALQLASKMARHSPLALQAAKQALRQSQEVALQAGLAQERQLFTLLAATEDRHEGISAFLQKRTPDFKGR
Protein: NFAT nuclear factor, isoform A (Q9VYA6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLLKFTKTSGAGPSAVPLLTTAPATVTSSASMQATTTSYAARGTGMRMTMSTNSTMSARIHRKGFRIPSKRQPGKGLPGKLHTITRTGPGKMVPGKRIPQRPHPPPCDNSNDSGLGFDQHTELRSSAGAGGVTDPAANGGSGSNSGQRSSLLVNSALTNTVAAAAAAAAAAVASNTLQQHQQHHQQQQQQQQQQQQQQQQQQQQQQQQQHSPQQHLIRAIPVSRSRNNTKVMAHCLEDLDLISASSEDSSTIATPAGLDEDTGFVNDTKTTTTGGNSSSDPFGGVFQATEAAVAAAVNAFNLQQQQHSVQQQQHQLFQYNGLLLQPQQQLQQQQSHHQQQQQQQQHHRHGKHIKRKKLECNQVELDNDDACSEDEFIRKIASSVTMSPTLEATPSPPPIVASVAPATTIVSLLPLISSGNSNNNNNNNNIETKFISARNVTRVANKRQPTTPLNSVASSNDGQVQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGYDKVAVLQVFIGTDIGRVAPHMFYQACKVAGKNSTQCNEKKVDGTMVIEIDFKPETDMTITCDCVGILKERNVDVEHRFPEHLAQKNKKKSTRCRMVFRTQLTRDDGTTETLQVCSNPIICTQPPGVPEICKKSLNSCPVDGGLELFIIGKNFLKDTHVVFQETYDSVNGDDPATEIAVRQQLIGGTAALWEQSVLPDKEYLHQTHLICTVPPYLHQNILKPVQVQVSIVSSGKKSEPHTFTYTAKGQYTTLAAASTLSNTIHAQDVSGFMDTTSASNASGSSGWSAAGGSGNNTSTGDNVEAKHEIDSGMMPPPITTQIPMGVRRSSLPSVTPMITDQQLVHLNAVAASAEALKTELDDSNSHSPLTGESTPDSPNAALQYHRFARKPSLDTIMYDQSNSLPGFPTVVAPATAAAVAAAVDIDPTAVAVAVELAVKNEIVKHVVQQHQQMQEQMHEQQQQQQQQQQQQQQQQQQQPQQQQQQQVHKFIDELTKSTSVVSSNGTTEPALFTTSAVIDHALTDILQAKVGIAPPNVVLERSLSLSSTNSSSSMSGSESSPNSSPLTQDIILNSEPAAALAGAAALGGPAPVDVTGGLSTDIIMNPAVSPSTILCSANGAATAVVPNILAPHQVTMANSILNDIAMQPEPTQQDAAVAALALSNIMMSPPTAASGVGVGDTLPPTPATMQPEVAATATSTAVSNMIIKAAADFITTQEQEQHHYHHHGRIHSHSPQAAVGVSGNPAETASDPLVDLLLNHSNTPETAAAAAAAVAVEAANFQSMNHSHHSHHGHHGHSHGHGHSRVTGHVSGHVTSHHRGHHLPVVPPTPQESLIVALASENALQKSVATAAVTTNGAVMTQQASAPNTAGSILPAAVGAVAAAAAVAVQPPIPQELTTMSDQDLISYINPSTFDQL
Protein: Mannose-binding protein C (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin) (P11226)
Organism: Homo sapiens (Human)
Function: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response.
Subcellular location: Secreted {ECO:0000269|PubMed:7982896}.
Interaction partners:
- Mannan-binding lectin serine protease 2
- Ficolin-2
- MBL associated serine protease 1
- Trypsin-2
- Ficolin-3
- Calreticulin
- Complement C4-A
- Plasma protease C1 inhibitor
- Pentraxin-related protein PTX3
- Complement C4-B
Sequence:
MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI
Protein: Biotin carboxyl carrier protein of acetyl-CoA carboxylase (O25135)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
- Biotin carboxylase
- Beta-ketoacyl-[acyl-carrier-protein] synthase III
- Malonyl CoA-acyl carrier protein transacylase
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- Biotin operon repressor/biotin acetyl coenzyme A carboxylase synthetase
- Citrate synthase
- Fumarate reductase cytochrome b subunit
- Fumarate reductase iron-sulfur subunit
Sequence:
MNLSEIEELIKEFKASDLGHLKLKHEHFELVLDKESAYAKKSALNPAHSPAPIMVEASMPSVQTPVPMVCTPIVDKKEDFVLSPMVGTFYHAPSPGAEPYVKAGDTLKKGQIVGIVEAMKIMNEIEVEYPCKVVSVEVGDAQPVEYGTKLIKVEKL
Protein: Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) (Q586Z5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Triosephosphate isomerase
- Phosphoglycerate kinase
- Phosphoglycerate kinase
- Phosphoglycerate kinase
- Fructose-bisphosphate aldolase
- Glucose-6-phosphate isomerase
- Transaldolase
- Phosphoglycerate kinase
- Transketolase
- Glucose-6-phosphate 1-dehydrogenase
Sequence:
MSVALFFSSFLTVPYFPCICLSFCGAEFIRANQTSKRLTTNLNMTIKVGINGFGRIGRMVFQALCDDGLLGNEIDVVAVVDMNTDARYFAYQMKYDSVHGKFKHSVSTTKSKPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTVKSAAEGHLRGGARKVVISAPASGGAKTFVMGVNHNDYNPREHHVVSNASCTTNCLAPLVHVLVKEGFGISTGLMTTVHSYTATQKTVDGVSVKDWRGGRAAALNIIPSTTGAAKAVGMVIPSTQGKLTGMAFRVPTADVSVVDLTFIATRDTSIKEIDAALKRASKTYMKNILGYTDEELVSADFISDSRSSIYDSKATLQNNLPNERRFFKIVSWYDNEWGYSHRVVDLVRHMAARDRAAKL
Protein: RBR-type E3 ubiquitin transferase (EC 2.3.2.31) (Q9SJT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEKHDLTLISKKRRIDFATTGDIPNLKGEGVSMVAESASASNIFADSLVYRLFFKGLVSDETTTDMEEIVKAGFGIAICDEANTLLYNMKKSLNGDDVINPEEVEIKALICVLNVSIQMELRNVMICCGDYQIFQILTGRGKPQQNIVHLVEQVQHLRGKLSSTEVVLVPRADVIILAIEAIGGETCCICRENTDADRMFFTENCFHRQCFSCVNRHVQRMLLCGISPTCLHFPCNSELTFESCSKVLTPNLIEFWKRKIEEDLVPAADKIYCPYRRCSMLMSKTALSRETDQSNVRACIKCCRLFCIDCKVPSHAGLSCVDYKKLNPDPLYDVKLKSLANKKKWRQCVQCSNLVELFEGCNHITCRCGFEFCYVCGKEWNQRGCLSPGCDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDEDDGYIDSDDDDVDGDDNDDGSELDGINFEDFAVHLPKDVNEQKDESN
Protein: Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (B4F7B7)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation. Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination. May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9H1R2}; Lipid-anchor; Cytoplasmic side.
Interaction partners:
Sequence:
MGNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIVSIHESPQPLLQDITYLRISVSDTPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTVVIAYVMTVTGLGWQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQKLRRQLEERFGEIPFRDEEDLRALLPLCRRCRQGPGTSAPSATTASSAASEGTLQRLVPRSPRESHRPLPLLARVKQTFFCLPRCLSRKGGK
Protein: Uncharacterized protein (Q57XS1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Rhodanese domain-containing protein
- Large ribosomal subunit protein uL3m
- Uncharacterized protein
- 50S ribosomal protein L16, putative
- 50S ribosomal protein L17, putative
- Mitochondrial RNA binding complex 1 subunit
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MLRHCTAHRRYRTAWRELLHPLPVRARKMEWLKRDAVEENEEILRRPYYTIKSYALPPAVGRQESIHNSNNIRGGMHSSHSLDLIMRQPRRVKTPEQLQALRDRLRFIGVTGPMPQATSVSTKSYADTYGSRLRPRYPESWDTVPPHQPSRELL
Protein: Inhibin beta B chain (Activin beta-B chain) (Q91350)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MALLLLPLLLAGLARTCAPSPTPEPGCPSCHPPMEPEMLEAVKRHILTLLHMQDRPNITHMVPRAAMVSALRKLHAGRVREDGNLEIPDLDGHSLPPPGHSTENSAEIITFAETDDVTASRVRLSFTIANEGNQNLFVFQSNLWLYLKLPEVMDKSRRKIRIKVHFQDAFNPDKMNMVEKKVDIRRSGWHTFPLTEAIQSLFEEGERRLNLEVQCDGCGEYSVIPVYVDPGEESHRPFLVVHARLADNKHRIRKRGLECDGHTNLCCRQQFYIDFRLIGWNDWIIAPAGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVDECGCA
Protein: Peroxisomal membrane protein PEX3 (PMP PEX3) (Peroxin-3) (Peroxisomal membrane protein PAS2) (Q92262)
Organism: Komagataella pastoris (Yeast) (Pichia pastoris)
Function: Involved in peroxisome biosynthesis.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:10359594, ECO:0000269|PubMed:21576455, ECO:0000269|PubMed:8702562}; Single-pass membrane protein {ECO:0000255}. Note=Traffics to peroxisomes via the endolasmic reticulum (ER), where it accumulates in the absence of PEX19. {ECO:0000269|PubMed:21576455}.
Interaction partners:
Sequence:
MLEYTAGLIRRNKKKFLISSGIIGVGYYVTKTINNKIQEFQNRIREENFAKEQIKRRFHQTQSDCYMTFLSLLPVLCEPIMDDLPVETITKQLQIRRLEKQIGNKDVKNSGSTVLSDDFSTSQEGAISEDTNKPPELKSKNQLWQELKIKAITRFLTLIYCESLLIVFLHLQLNILSRKSYLETAIRLASETQGIDLVDQESNGDFSGNTQDENLSEQAFLSFSWWLLNKGWLEIKNKIEPCVEQHFGGINPRQQLKINEFAELLNKCQNCIDLKVLNLTEEDIHLGVGVIEDQSQPVGRKSTNFITNALLPPKEFEFFLLQQTNDLDFLSRFNNNIVNTESLNMLLDELNNYLNNADINLIVNKLATLGITKVLDEIVLNLLQKNRPNPISDMNIRDIDLNDFPPYKLAALLANITKQSISLTNNSVENPILADLNNLPELNDLSASVYSNFDP
Protein: DNA-directed RNA polymerase, putative (Q383N7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- PWWP domain-containing protein
- Transcription elongation factor, putative
Sequence:
MSAPMARRDYFSMGSRCCIACGQWIPSEHDMPRSGSAAAGGLQCRRCNVVQPERPMPDFEKASEVTTAALLFTKAEIDAAWKSVKHSLEEARREDVGVAQTDNRVEEEAFCEKCGVPRKCKVFARQIRSADEGQTVFYQCTSCDSEWQLNS
Protein: Kinesin-related protein 13 (Kinesin family member 13) (Kinesin-5) (Q6RZZ9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with dynein to control the spindle elongation rate, but is dispensable for mitosis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Kinesin-related protein 2
- Probable serine/threonine-protein kinase mps1
- Tubulin beta chain
- Probable inactive serine/threonine-protein kinase bub1
- Aurora kinase
- Mitotic spindle assembly checkpoint protein MAD2A
- Tubulin alpha chain
- Kinetochore protein Ndc80
- Uncharacterized protein
- separase
Sequence:
MITGLSIHNQINKKNEPVKKEQNIQAFVRVRPFSVYELNQGVTTVPIRVSDSSKEVLCEYKGTTRQYKFDHVFDQDSIQSEVFNIAVKPICDEVLLGFNGTIFVYGQTGTGKTHTMEGKHGSNEDMGIIPRTINYLFQCLEQSGADYNIRASHLEIYKEEIFDLLACNGNENLNKPLGMFDTQKGFKIPELEEIVVNDRQSILNVLAKSCKRRQTAETQYNKQSSRSHCIFSITVHVKETSVGGEDLIKIGKLNLVDLAGSENAEKSGNNDRLREAALINKSLLTLGKVITDLTNNEKHIPYRSSQLTKILQDSLGGKTKTSIIATVSPSLVNLEETINTLEYALKAKNIKNTPQINQRMSKNSLLKEQSSEIAHLKQLLQAAYDKNGVYLTIDVYEQMKRELEEKCSQQSITEHKMEAQRHEISSMRKSFDEQTMLFEEAMNELESSKKQQQEKQKFIDQFISQDTMLRSNLGSAVQDLSKLHEKLDTMKSTERENQKSIIDSKSILSKRLTDLNQMLVSKLQMGQNELLESLSVQLKVVHDQQTKSNQLIGKRINNLSQLIDSSVLQIQQLNNDDKQQTQPLLKLNKESNDLFMKLDKTIQQLSDQIKIILSDFSLPFFNSNNNNSNNGDEIIDDSLINNCFKLINDHVNKSDLIVSQQNKLIQEFSESMSQWMLHQSQYIIEQRDYQKQLKEKQILNNTQWEKKLLSKLGQVIQQFSKNFTDSTSVYYDTMDNNLQHFEKQFNSINNHSRQQVESLSNNLQQSSTLSHQFESTVKSVLNDHHANNKKVDPKLIESIEKAKKRINQLTDGCIDLSQRQRQCTNQFNEAFTDFTFGIQSQKDILDRVIIEKNQVHEILPLIEKSKSTFKENIDTLIHSLDSRKSIIQSSTNECSNQLNSLISSIPSYLDSAIKVTSKSGETPSKKHFDIPSPISTSSSSSSSSSISSIHSNAGGKENNHQSINNSIKSNNFDGSKSINCDNMKIDTPQKSSTIPITPKSLKLNLNSTPKSVSKNLKSSQQQQPLIVPSSNQLTLSAKKLSNKEYQRLQQQQQQQQQEQQQQQSAKKKKLAIEKQLMITTSPTLSLVNESPFSSPKLSKQKILQDQIQPPQPPSILSQLNSTPISFLQPQQPQQQPPSFFNNLNGSFNRGNNSIDFSLLDDDSDSDNSDDDVRSLLSSNKKSSRASKNAVVSKKVGLTPSRKLKGVNSSANQSLNVKKSKPILTSLSKKQNISTPIIHSSKPSIFGGGSTISSKLKSLKQQTPLK
Protein: CyaB (Q9HZ23)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- cAMP-activated global transcriptional regulator Vfr
- Cyclic AMP
- Adenylate cyclase
- Protein PilG
- Protein PilH
- Probable transcriptional regulator
- Scaffold protein FimL
- cAMP-binding protein A
- Nucleoside diphosphate kinase
- Pyruvate kinase
Sequence:
MKPTLPDRSPTSRSVASMREYYSRVLAYIACGASIAAGTYTQYFSYGILWMVPYALLYPHLAYHLGQRFRQHDPRKVTRALLAVDAVHCGLGMALLGFSVVPSLMFLLVLSFTALVIGGLRLLGMALLVSASSALLVAVLVAPPLLGNTPVEVAAVSILFCGLYICITAFFGHQQGLRLAQVRQEIAREQEKAARLARNLAKYLSPQVWEMIFSGKKSVRLETQRKKLTVFFSDIRGFTELSEELEAEALTDLLNNYLNEMSKIALKYGGTIDKFVGDCVMVFFGDPSTQGAKKDAVAAVSMGIAMRKHMKVLRQQWRAQGITKPLEIRMGINTGYCTVGNFGADTRMDYTIIGREVNLASRLESASEAGEILISHETYSLIKDVIMCRDKGQIAVKGFSRPVQIYQVVDSRRDLGAAPSYVEHELPGFSMYLDTNNIQNYDKERVIQALQQAAERLRDKVIL
Protein: Troponin C (TN-C) (Q9BLG0)
Organism: Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus)
Function: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Interaction partners:
Sequence:
MPVVISEKQFNDAHQAFKLHDKKDEGAVSNKELTNLFKSLALHVSDDKLQQWVDEMDEDATGVIRWEKFKILFERKVQEDEDERELRSAFRVLDKNNQGVIDVEDLRWILKSLGDDLNDDEIQDMINETDTDGSGTVDYEEFSALMLG
Protein: Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (O01822)
Organism: Caenorhabditis elegans
Function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22916203}. Endosome {ECO:0000269|PubMed:22916203}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 4
- SNAPIN protein homolog
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Dysbindin protein homolog
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- C-type LECtin
- C2H2-type domain-containing protein
- BLOC-1-related complex subunit 6 C-terminal helix domain-containing protein
Sequence:
MSNTEHNVESKNVTDTLDEILRLQEDIQARIGSSNHNLETNFESIKDFVSRAHAYIPILNQISKDMIEICERTQALKKKTSQLELSDTNIEDGSTTSTPTTTNKSQ
Protein: Rho-GTPase-activating protein 8 (Q09697)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts in signal transduction. Negatively regulates the pak1/shk1 control pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14506270}. Note=Localizes to the cell ends during interphase and to the septum-forming region during cytokinesis.
Interaction partners:
- Probable Rho-GTPase-activating protein 7
- Rho-type GTPase-activating protein 1
- Rho-GTPase-activating protein 5
- Serine/threonine-protein kinase shk1/pak1
Sequence:
MISSFSNGFWSKDYATGVKKLFDCLDNGVEENEQVKNLLKLYKEANEEFGEKLQEITKECLKGKKPENTEDGATSNKAFEGLRSEIANQGKQHIRIAKDLETLIIAPFSKMSIDHSQKLQTSQQVLTNQIKSYEKKYYTLKKTKSAYYNKCRNLEDYEEESKESNETTSEAITDLTTVSSPQQQSLLENDDDLIQLGFMEFRPEELKEVLAQVLQEIPLQDYRVPILGTYPNTCSGNIIVSWLQENLPVPTLVAAEAFGQDLIAQGFLRHMGVGGSFVNSTNFHYQWKDKAFQFAGLNSVDSLVENAKALPLVGEYLSDYISHRKLYSSETQSQRLKREVLDANKIYSESVVDLDKCRTLVEETIADHLQFLQKCETDRVLYYKDFFMDLSTIISNFLPSMKLLADQIVVYQEIIQPESDIRYILESAATGPFLPRVEIYEDYYNDIKDQIFGVDVEFLSHRDKKRVPIIVSTILSYLDLLYPTLASDEVRQNIWLVNSPLSSVHQLREALNHSSSVTKEVLSQYTPSVVIGVLKLYFLELPDSIVPSSAFELIRSIYMNHSNDTPYRLRLLQNLLSQLRRVNLATLSAIITHLNRLITLTPNKETFTINLANSLSLCISRPATWNLGIQHDKHPTKFMEDLLTYGPSIFEELRKLNSSKRVSDRVLYQSSATPRSTDVSPTRPDSISSVRSHTAVESPRSSFEELQPSEIPAESEFTLENVPTSLIRSSYALNTRKTRRNFSHSSASNESAAIFIDQDAKIVNEAVASRDSSLSGS
Protein: Uncharacterized protein At1g65030 (Q8H177)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSIIAGSYERFIWGFKLKPTKHDAESQTLTLSPLFSYPSHISPITTVACSGPAAASGGSDDTIHLYDLPSASSLGSLLDHNHAASITALSFYTPSSLSFPRNLISAAADGSVAIFDTDPFVLLKSFRPHKKAVNDLAIHPSGKLALAVYRDEFFAMLNLVRGKRSFCCRLGHEASLVKFDPSGERFYMVVSNKVGVHQSEDAKLLLELENPSRKRILCATPGESGTLFTGGEDRAITAWDTNSGKLAYSIEDAHPARIKGIVVFTRNDSDGSLEDPYLIGSASSDGIIRVWDVRMAAKENTKPLAETNTKSRLTCLAGSALKSMRRPQIGKQEPQKVDEEHEDSE
Protein: Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) (P49117)
Organism: Mus musculus (Mouse)
Function: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation (By similarity). Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Juxtaposed with another zinc finger protein 1
- Nuclear receptor corepressor 1
- Nuclear receptor subfamily 2 group C member 1
Sequence:
MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSSKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLAADSKAETSQGALGTLANVVTSLANLSESLNNGDASEMQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDASGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL
Protein: Rho GTPase-activating protein (F4JEP8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 21
- Holliday junction resolvase
- SMAD/FHA domain-containing protein
- ATPase family AAA domain-containing protein FIGL1
- At1g65985
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
Sequence:
MDSIEPPSFSLGFDLDAASDLQSEIHQNPSSTGDQLIGDGDNEPELGLTVSDSDRELEPDFTSPVLKRLRRGINPNKCSVKDDRSVAVEDRDDDIEEFSSPEDFPTDAPASTRSHFSSCSSRVPLHGSGVLSNQPSISRGKRKQSDVQASAASGISSVASLFQMSSRSPLRRFQLLDSDSEDDHPSTSRDLSGATKKHDSFSKNQPSIASKPKRKEPGSIPCIKDLWKDFSPASSKIQTPAFDDVCQDYFISIKTTSTAQKQSSAVASSSNSGNHNLTGFQQTELFHDFSHPSPPSHRFFLHSDPRIRNLARQRLPNFFPLGIVNDRESQREVFLVDYMNQFGSKGSSKAGDSSSKSCRRGKTKSKVSKSQESAHNSEGWLNPKTRAAAPKDAGKRRVSADSGSAGHWFTSPEGRKVYISKSGQEFSGQSAYRCYKKENGVGFKKSRKKRQPKKKAKN
Protein: Uncharacterized PPE family protein PPE46 (P9WHY9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- PE family protein PE27A
Sequence:
MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVAAATITPFPWHEIVQFLEETFAAYDQYLSALLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIVVEWVIGNLFGVVPLLGGPLLGALAAAVVPGVAGLAGVAGLAALPAVGAAAGAPAALVGSVAPVSGGVVSPQARLVSAVEPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTVLADEFGDGAPVPMLPGSWGPDLVGVAGDGGLVSV
Protein: SRR1-like protein (SRR1 domain-containing protein) (Q8K2M3)
Organism: Mus musculus (Mouse)
Function: Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28802827}. Note=Also found in intracellular organelles. {ECO:0000269|PubMed:28802827}.
Interaction partners:
- Aspartate beta-hydroxylase domain-containing protein 2
- Coiled-coil domain containing 121, retrogene 2
- Coiled-coil domain containing 121, retrogene 3
Sequence:
MAAAALEPWSAVAPRRRKRAAGRRPRPGEGPRAEPEADGEAVLRRLREAEEDLRISDFCSSALETITECLRKQLEQLQPLTEALGRLHLGSSLPSASQEPLASSASHVKCVCYGLGTFASCPTARIQLAFMLLFLEKCQVPRSHCWVYDPLFSQTEVSVLTSLGVTVLSENEEGKRSVQGQPTVFYMPHCGTALYNNLLWSNWSADALSRVLIIGNSFRGLEERLLARILQENYPYIAKVSDRIAGPGF
Protein: PIH1D1/2/3 CS-like domain-containing protein (Q57VM8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVLECDSELSFFFPFGPTVALVFHLSVLPRCSNISLTDCKGLHGKLLFVLLYLMLEISSPFHSEVELKGRRSGVPEMAVTSKAKKEEAELRKIAKQARTARKEVAAKERRLKLKGKKRQQTDGTDRENISSKPVTGGHSVKRQGAIILPEEAAEVRQRLLSDTRIESGAAAPENGGAKRDTAITSSQLSNAAAVSRQKPLLSSSSRVEEPAHSVEVHHKRKQFLVGVALHHVPPQHIDVSGTTATALVVDTCKHTKKYRLVLPMPEGICVDPAQAEYEFDCGVLRCVLPIVGEIPSSLRQERDAMLESIQKQKTLRFRMGEDGELKVRSRRALLGNGELKDADGDDKRRKIDENNALRVSGGKKREVRQQAEDVEDDGADETAGEKGKAEGARNREGRCTKRAREVVETSPLQKAGKLQQQRPSQREEQISNNNIVKKKRKGPDSALEEEQKKALELAKAAGRAAKATLRERVAQAKATQQRMLQRMVNRQNRRETQSKKTRDSFARVLEEQKRQLIARAERTAVATAVAAGGKSDGRCGAKGRQSGGKRVTFAESKGSAEE
Protein: 5'-3' exonuclease PLD3 (EC 3.1.16.1) ((S,S)-bis(monoacylglycero)phosphate synthase PLD3) (EC 3.1.4.-) (Phospholipase D3) (Schwannoma-associated protein 9) (SAM-9) (O35405)
Organism: Mus musculus (Mouse)
Function: 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IV08}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8IV08}. Lysosome lumen {ECO:0000250|UniProtKB:Q8IV08}. Early endosome membrane {ECO:0000250|UniProtKB:Q8IV08}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8IV08}. Late endosome membrane {ECO:0000269|PubMed:28128235}; Single-pass type II membrane protein {ECO:0000269|PubMed:28128235}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8IV08}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8IV08}. Endosome membrane {ECO:0000250|UniProtKB:Q8IV08}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8IV08}. Note=Localizes to ER-associated vesicles in differentiating myotubes. Sorted into intralumenal vesicles (ILVs) in lysosomes. The soluble form in lysosome arises by proteolytic processing of the membrane-bound form. {ECO:0000250|UniProtKB:Q8IV08}.
Interaction partners:
- Phospholipase D2
- Phospholipase D1
- 5'-3' exonuclease PLD4
- Phosphatidylserine decarboxylase proenzyme, mitochondrial
- Phosphatidylcholine-sterol acyltransferase
- Lysophospholipid acyltransferase 5
- Membrane-bound glycerophospholipid O-acyltransferase 1
- Phosphatidylserine synthase 2
- Phosphatidylethanolamine N-methyltransferase
- Choline/ethanolaminephosphotransferase 1
Sequence:
MKPKLMYQELKVPVEEPAGELPLNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLEFPNATTSNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLQQLQALAPRGVKVRIAVSKPNGPLADLQSLLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRSFDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDSARSFIYIAVMNYLPTMEFSHPRRFWPAIDDGLRRAAYERGVKVRLLISCWGHSDPSMRSFLLSLAALHDNHTHSDIQVKLFVVPTDESQARIPYARVNHNKYMVTERASYIGTSNWSGSYFTETAGTSLLVTQNGHGGLRSQLEAVFLRDWESPYSHDLDTSANSVGNACRLL
Protein: Probable calcium-binding protein CML46 (Calmodulin-like protein 46) (Q93Z27)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- Heavy metal-associated isoprenylated plant protein 14
- Calmodulin-binding protein 60 G
- Probable calcium-binding protein CML40
- Phospholipase like protein family protein)
- Classical arabinogalactan protein 5
- Probable calcium-binding protein CML16
- Calmodulin-like protein 8
- Calmodulin-like protein 9
- HXXXD-type acyl-transferase family protein
- Calmodulin-like protein 12
Sequence:
MTENQLYSFITMKSSLSKCKQSSSLSFPLFGLINFFLIGFFRWVSFAQLFFSRFWPLVQHQQCVSEKKSKDLEFQTSIKHEEYRDDDDDGLCREDVGMVMKSLGLSTDQENEGLQKQYSSKEVSNLFEEKEPSLEEVKQAFDVFDENRDGFIDPIDLQRVLTILGLKQGSNLENCRRMIRSFDGSKDGRIDFYGFVKFMENNFC