Protein: Ras-related protein rab-11.1 (Rab GTPase rab-11.1) (O01803)
Organism: Caenorhabditis elegans
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in regulating the meiotic maturation of oocytes. Plays a role in egg shell formation, regulating exocytosis of chondroitin proteoglycans following fertilization. Controls cortical granule localization and targets them to the plasma membrane for exocytosis. Acts as a major regulator of membrane delivery during cytokinesis. Regulates the cytoskeleton by facilitating astral microtubule elongation and organization during metaphase to ensure proper spindle alignment and polarity in the first embryonic cell division. Maintains normal endoplasmic reticulum morphology during metaphase. Involved in vesicle formation and plasma membrane repair following exposure to pore forming toxins. Regulates endocytic recycling. May play a role in yolk receptor endocytosis in growing oocytes. Plays a role in the shedding of pathogen spores from intestinal cells via its involvement in spore fusion and endocytic trafficking.
Subcellular location: Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:18765566, ECO:0000269|PubMed:20116245, ECO:0000269|PubMed:22992455}. Endosome {ECO:0000269|PubMed:19158384}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18385514, ECO:0000269|PubMed:19158384}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:18385514}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18385514, ECO:0000269|PubMed:19158384}. Apical cell membrane {ECO:0000269|PubMed:24843160}. Cytoplasm, cytosol {ECO:0000269|PubMed:24843160}. Recycling endosome membrane {ECO:0000269|PubMed:18385514, ECO:0000269|PubMed:18472420, ECO:0000269|PubMed:18765566, ECO:0000269|PubMed:22634595, ECO:0000269|PubMed:26506309}; Lipid-anchor {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:18765566, ECO:0000269|PubMed:26506309}. Cytoplasmic granule {ECO:0000269|PubMed:18385514, ECO:0000269|PubMed:26506309}. Note=Expressed in endosomal vesicles which localize to the pericentriolar region of embryos during prophase and metaphase (PubMed:19158384). Localizes along the spindle in embryos during anaphase (PubMed:19158384). Transiently accumulates on secretory vesicles before their exocytosis (PubMed:18765566). Localizes to recycling endosomes and Golgi apparatus membrane in growing oocytes (PubMed:18765566, PubMed:26506309). Translocates to cytoplasmic granules and extracellular matrix components in mature oocytes (PubMed:26506309). Accumulates on ring-shaped structures in ovulating oocytes and in early one-cell stage embryos (PubMed:18765566). Redistributes to recycling endosomes and Golgi apparatus in embryos (PubMed:26506309). Co-localizes with rei-1 at Golgi apparatus membrane in embryos (PubMed:26506309). Reycling endosomes co-localize with the endoplasmic reticulum in embryos (PubMed:18385514). Co-localizes with rab-6.1-positive vesicles near the plasma membrane until vesicle exocytosis in embryos (PubMed:22992455). Localizes to the cytosol during the meront-stage of N.parisii infection and around the resulting spores that are to be shed from intestinal cells (PubMed:24843160). {ECO:0000269|PubMed:18385514, ECO:0000269|PubMed:18765566, ECO:0000269|PubMed:19158384, ECO:0000269|PubMed:22992455, ECO:0000269|PubMed:24843160, ECO:0000269|PubMed:26506309}.
Interaction partners:
- GDP/GTP exchange factor Sec2 N-terminal domain-containing protein
- FIP-RBD domain-containing protein
- Myosin motor domain-containing protein
- Rab GDP dissociation inhibitor
- Phosphatidylinositol 4-kinase beta
- Ras-related protein Rab-25
- Guanine nucleotide exchange factor rei-2
- RAB family
- Exocyst complex component 7
- Exocyst component Exo84 C-terminal domain-containing protein
Sequence:
MGSRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSISVEGKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHVTYENVERWLKELRDHADQNIVIMLVGNKSDLRHLRAVPTDEAKIYAERNQLSFIETSALDSTNVEAAFTNILTEIYKSVSNKHVGTDRQGYGGGSGTIIPSPASDPPKKQCCIP