wanglab/gogpt-training-data huggingface dataset:
Protein: Probable G-protein coupled receptor 101 (Q96P66)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MTSTCTNSTRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLEVRVKDCVENEDEEGAEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSVEARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGEDDINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDMLKKFFCKEKPPKEDSHPDLPGTEGGTEGKIVPSYDSATFP
Protein: Pleckstrin homology domain containing A7 (A0A1B0GUN0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
NSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKIKNNEPLINVLYKVLKKSARGCRPRRSMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKAKPKVQEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLGQGERTGLPSSRYLSRPLPGDLGSVC
Protein: Uncharacterized protein C191.01 (O94733)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MVTRRLSTNVHIDLQPIRQGILLPFHDRPAEMRDLAKCNDQFFRNVRDTISEPKFTQLMELWLEKSRAEVPDADFLMTTRNIMLSFPSNEEQGHQRSASHGSTSSATSTPKRLSISSMDPARIHLWRQFCNVVGYDMPTPGEQKEAPPSPAQEAIPESPVEEAIASDSDEEEEEEIKA
Protein: Innexin (Q17394)
Organism: Caenorhabditis elegans
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU010713}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU010713}.
Interaction partners:
- Receptor-type guanylate cyclase gcy-13
Sequence:
MLLYYLAAIFKGLHPRVDDDFVDKLNYHYTSAIIFAFAIIVSAKQYVGYPIQCWVPAQFTDAWEQYTENYCWVENTYYLPLTSAFPLEYGDRRARQISYYQWVPFVLALEALCFYIPCIMWRGLLHWHSGINVQSLTQMACDARMMDADARAATVQTIAGHMEDALEIQREVTDVSGMCVQKRWANYVTLLYVFIKMLYLGNVVLQVFMLNSFLGTDNLFYGFHILRDLLNGREWEVSGNFPRVTMCDFEVRVLGNVHHHTVQCVLMINMFNEKIFLFLWFWYFMVAFVSAVSMFHWIIISFLPGQHMKFIRKYLRATDLATDRQSVKKFVHKFLGYDGVFCMRMISAHAGDILATELIVALWHNFNDRVRKSPIEMFEGGVTQSPSKLDANFKTWLLGQTRGKPPFDGSNPTRGKKRRKSDGYFTFV
Protein: Probable NAD(P)H-dependent D-xylose reductase xyl1 (XR) (EC 1.1.1.307) (Q2UKD0)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).
Interaction partners:
- D-xylulose reductase
- D-xylulose reductase A
- L-arabinitol 4-dehydrogenase
- D-xylulose reductase
- D-xylulose reductase
- D-xylulose reductase
- Enoyl reductase
- D-xylulose reductase
- Zinc-dependent alcohol dehydrogenase
- D-xylose 1-dehydrogenase
Sequence:
MASPTVKLNSGHDMPLVGFGLWKVNNETCADQVYEAIKAGYRLFDGACDYGNEVECGQGVARAIKEGIVKREELFIVSKLWNSFHEGDRVEPICRKQLADWGVDYFDLYIVHFPVALKYVDPAVRYPPGWNSESGKIEFSNATIQETWTAMESLVDKKLARSIGVSNFSAQLLMDLLRYARVRPATLQIEHHPYLTQPRLVEYAQKEGIAVTAYSSFGPLSFLELEVKNAVDTPPLFEHNTIKSLAEKYGKTPAQVLLRWATQRGIAVIPKSNNPTRLSQNLEVTGWDLEKSELEAISSLDKGLRFNDPIGYGMYVPIF
Protein: Rap-GAP domain-containing protein (V6CLC2)
Organism: Caenorhabditis elegans
Interaction partners:
- Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein
Sequence:
MFARKGKSSDVQASISRFTDLNRDCVSRVKHLKILLDTLTTNEKRQLLDEHSFETFHLVDELLLVNDVSSQIDSAIEAESGLWTLEQVLCLAPELVGSGWQRHAIESLLKKAVYPKNLMAVRKIAIRLFLVFYQCLGVYGKATPDLDRVFQCLLPFFPLTSGENAEDVLNEYCQSSGAGDWCERLRNGPIKSTASASQTSKERAQMLQVYLDKFLEYCTRETVRIEWNDEGKRQECANFIIEKVIKLYMGECFTDLETNGVDVFGGWEGADENGEPLDTADPVVIARYWLIRWINNIASATTHTTAGGQPTLQTTHASLILYRNALFSSHKATNVALTLMREAMKLPLACSNVTHKVVNVLSAWLLQYEIPPFVASGEVSIERCSLLLSNILLGFFHSPYLAQCGERHSSAISIAFAILTSCKQLVSHRIQLPKPLPQKFWSELMAGLCTCASKICRQSDAFSQNVSAAFTSTLISNVVVIKAVRRIEIDDEVWDEVHDVMKKGVWIPMAEQWASIVNSVTRALILHLAHIDIFSREEALRKATEVSQNSRRQAIESAMMEDPRNDSSETGDSMSSSNTIAEDNVFHDTDDITNAVTSWSGDKLAWLQTWRRVISLVDPYTNSSAHVAIDCMSLTIENLLLVNLHPLAHWLACRLVTVPPILLPRCVPALSAILNESTIRRPPPLLSANILLCFIRLMQSKEQLVVPAICGLSAHELSIVAPRALEHLPKMLQAAKSSKDTKVSSNSLKLFSMLASSYPGAEQILLDQLVNTDVSENAVVIVNSLAILIVQKAQIDLVLTALKTIETHQFAMRLIPLFCSSIASLAQFSSTTLLQALLRAASLLRDERTRTEIEWQMVKLCMQWPQPQMPLVIRGILADRHMVLHGELVTLGGQYPVRGFEVQRWSSAGAPPLQGEDKTVYINRQSAIISVSRKDFHAKSPCEITSRTVVGRHIWDLDTHEDVRKPATNVTNWLRKEALKGKRPGRESQGILGAMDDPFDDLPDYPPSRGSPSPVDGAAQFTSMIETSRRQPQPLGTSSAAHDHLPAFTPNAKLLEWRSLSASLGFVPLVSQVHANFPRDLKHLDQTSSREVHKVAVIYVGESQEDRASILSNTTASASAQFDSFTSELGWEVKVGRGHDGYTGGLPVETRAPYFADAEAEVIFHVSTMLNGDVQQKWKHIGNDEVHVVWTENTRKVYTRETIATKFCDVLIVLEQVGDKMVRVRVDTASALEFGPLFDGALVTMSELSQLVRLTVINASRAYRLARVEHSRPLRHREEVFCNEALAHMKPMPLAQSINHLYVPTI
Protein: Cyclin-dependent kinase 20 (EC 2.7.11.22) (Cell cycle-related kinase) (Cell division protein kinase 20) (A0A2K5VFY2)
Organism: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cyclin-H
- CDK-activating kinase assembly factor MAT1
- General transcription and DNA repair factor IIH helicase subunit XPD
- Transcription initiation factor IIE subunit beta
- General transcription factor IIH subunit
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIE subunit 1
- General transcription factor IIH subunit 4
- DNA-directed RNA polymerase II subunit RPB3
- RNA polymerase II subunit D
Sequence:
MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGIPNQALREIKALQEMEDNQYVVQLKAVFPHGAGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDSSRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQAPVPLEEVLPDASPQALDLLGQFLLYPPRQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFIPEG
Protein: RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) (Q96PK6)
Organism: Homo sapiens (Human)
Function: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:25385835}. Nucleus, nucleolus {ECO:0000269|PubMed:11790299}. Cytoplasm {ECO:0000269|PubMed:25385835}. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles (PubMed:11790299). Cytoplasmic localization is crucial for its function in suppressing the formation of aberrant centriolar protein complexes (PubMed:25385835). {ECO:0000269|PubMed:11790299, ECO:0000269|PubMed:25385835}.
Interaction partners:
- Non-POU domain-containing octamer-binding protein
- Splicing factor, proline- and glutamine-rich
- Paraspeckle component 1
- Matrin-3
- Heterogeneous nuclear ribonucleoprotein H
- Heterogeneous nuclear ribonucleoprotein K
- Heterogeneous nuclear ribonucleoprotein A1
- X-ray repair cross-complementing protein 5
- U1 small nuclear ribonucleoprotein 70 kDa
- Heterogeneous nuclear ribonucleoprotein M
Sequence:
MKIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRENAGALRAIEALHGHELRPGRALVVEMSRPRPLNTWKIFVGNVSAACTSQELRSLFERRGRVIECDVVKDYAFVHMEKEADAKAAIAQLNGKEVKGKRINVELSTKGQKKGPGLAVQSGDKTKKPGAGDTAFPGTGGFSATFDYQQAFGNSTGGFDGQARQPTPPFFGRDRSPLRRSPPRASYVAPLTAQPATYRAQPSVSLGAAYRAQPSASLGVGYRTQPMTAQAASYRAQPSVSLGAPYRGQLASPSSQSAAASSLGPYGGAQPSASALSSYGGQAAAASSLNSYGAQGSSLASYGNQPSSYGAQAASSYGVRAAASSYNTQGAASSLGSYGAQAASYGAQSAASSLAYGAQAASYNAQPSASYNAQSAPYAAQQAASYSSQPAAYVAQPATAAAYASQPAAYAAQATTPMAGSYGAQPVVQTQLNSYGAQASMGLSGSYGAQSAAAATGSYGAAAAYGAQPSATLAAPYRTQSSASLAASYAAQQHPQAAASYRGQPGNAYDGAGQPSAAYLSMSQGAVANANSTPPPYERTRLSPPRASYDDPYKKAVAMSKRYGSDRRLAELSDYRRLSESQLSFRRSPTKSSLDYRRLPDAHSDYARYSGSYNDYLRAAQMHSGYQRRM
Protein: Transmembrane protein (Q382I5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGSGFVTRLVSLRRRKRLLFHVVVVAFALYILSILFMLYADVSTSKNSASSAATPPSTPGSVAPSREWKPDELGPKITEYSTRVVGPQERDYILEVQKAALAEAGRSGLRAVTSRTLVDVGVSEKQLVSGFLTRVYNSDSAKSGPQVEGPLQLMPYYKQDSRRKDAHIAYYDGIIDLDQNAFAEAVENHLFSEMLLLVFSDWDEATDKYIALLQRLSEAMNPYKEAPQGSWHVLLNSILSKVSENQAPNVVTARVNAFATLSTGGGTGREGRNHLFLWPTAKSEGPVQVIAAIRKADFGEYHFFGSETLKMTLHSPSLFFCSGGKKNVHRYDGPLTEKGLINFVHAHTSSHLQLTKKEEIDAVLGKYDRFLLILCKGSGYNEGSGTSPMREILLENDDIHFKLRTKIPTFFVQEEMMEEAHSINWKALNIIETKELKLESLKFLVDDPQAGVTADFITQLHAFPLSDDTRLLLLDRMVPKGESKASPLDHFTGVALRFPAPSGKTNFSAWVNTVGTRLVDYAEDMMSEKAYLVPVSGLNMQHVYERHFRTSYLALKRRLRQRQGLTSAHGASKESLEDRGNNRFLVLVVLPPTGSERATGCERAARRAAGTARRDTNVQFASAAFEEAEELSKELRTVIWRDFDEKMSVTNCEVYVFNSDGDVRGVDMGYGELQGPKGGWGQLFHSDVGGSVGSPKHCMPAPRAPSPSVMYKALRGLRDSISKETNADARVTYRSILVSAVKGVAPSYLWIPEGESVPLIAYNQKVEDNRCEAAKEESVFLLLIHDSSCAATANHYKALRLLGNCQKKGVLPSSVKLLEYDISDHYTTLFTVEKLIQPIAAQVDVAKRTALYERLQPLLQHTASLHPPQLVVVNQTHILSTLNTATYYIQHSVSGHKPLKNGFVRTVANMLNLVDSGIHADRIASCMLQSLEDDRAARKKYRHTGKPEQ
Protein: Cytochrome c-1 (Cytochrome c At1g22840) (O23138)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:14671022}. Note=Loosely associated with the inner membrane.
Interaction partners:
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome c1 1, heme protein, mitochondrial
- Cytochrome c1 2, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit Rieske-1, mitochondrial
- Cytochrome b-c1 complex subunit Rieske-2, mitochondrial
- Cytochrome b6-f complex iron-sulfur subunit, chloroplastic
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 1
- Cytochrome b
- Cytochrome c oxidase subunit 2
Sequence:
MASFDEAPPGNAKAGEKIFRTKCAQCHTVEAGAGHKQGPNLNGLFGRQSGTTAGYSYSAANKNKAVEWEEKALYDYLLNPKKYIPGTKMVFPGLKKPQDRADLIAYLKESTAPK
Protein: Uncharacterized protein, isoform D (Q9VWJ2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAVFGMLVMHPVEWHMRRVPIQPEEQEELKELSPTVVIRVQPETPLKATREEPNFHTADPGARKLSHAEEQMLKVLSSRASSITSLGNWSGPVVVSDASPQMMHSLQTSRRPSTIAGASGAVAPAHATKKSWVRTIVDFLDLTLLKKPIFVNIVLGITFALYSDITFFTMQPVYLFELGYSRPDTATIIAIGAAADLASRIFLAITAVCIQVPSRYIYLAGAVFTVFARFAFNGITQFVGMACITAVIGFLRTWLHVPLPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIVGFIRDKTRDYIFVFHILNGFMILCAAPWVLEVLIVKFRRRNKIERNNVDHEDVDNQGRSAMVQ
Protein: Transposon Ty1-PR3 Gag-Pol polyprotein (Gag-Pol-p199) (TY1A-TY1B) (Transposon Ty1 TYA-TYB polyprotein) (p190) [Cleaved into: Capsid protein (CA) (Gag-p45) (p54); Ty1 protease (PR) (EC 3.4.23.-) (Pol-p20) (p23); Integrase (IN) (Pol-p71) (p84) (p90); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Pol-p63) (p60)] (P0C2J1)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
Subcellular location: Cytoplasm. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MESQQLSNYSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVQYGDFYWVSKRYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSASQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKPISEINLRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSNNETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDPPPEPPTELSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDRYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDTGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSHYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
Protein: Plant intracellular Ras-group-related LRR protein 8 (Q8RWE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
Interaction partners:
- Immune-associated nucleotide-binding protein 4
- F-box protein At3g17710
- At2g41380
- Serine/threonine-protein phosphatase PP1 isozyme 8
- Putative expansin-A17
- Zinc finger CCCH domain-containing protein 26
- Pectin lyase-like superfamily protein
- Polyadenylate-binding protein 3
- Protein SENSITIVE TO PROTON RHIZOTOXICITY 2
- Pectinesterase inhibitor 11
Sequence:
MMGYEQMNQMTMTTTAMMKNYNKKGLINTPQKKMTRRSVSAIDGGAAATAKEGDRRQNIKTLDLSGMSLASLSASSINLASISKLDLSNNNIQKIPESLVARMLNLWALDLQSNQLKTLPNSIGCLSKLKFLNVSGNYLQSLPKTIEDCRSLEELNANFNELTRLPDAIGFELTNLTKLSVNSNKLVLLPNSVSYLTSLRVLDARLNRLSSLPEDLENLVNLQVLNVSQNFQHLTTLPYSVGLLISLVELDVSYNGITVLPDSLGCLRRIQKLSVEGNPLISPPFEVVEQGLEALKQYMSEKMTESYKKTPTKKKSWGIGKLVKYGLSSSPGRSTGREDGKEGFINVSDYRQIDGIASPRHVSLFNPRRLLSPLSAYFSPPRY
Protein: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) (P04035)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17180682, ECO:0000305|PubMed:2991281}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}. Peroxisome membrane {ECO:0000269|PubMed:17180682}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}.
Interaction partners:
- Insulin-induced gene 1 protein
- Mevalonate kinase
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- Insulin-induced gene 2 protein
- Sterol regulatory element-binding protein 2
- Squalene monooxygenase
- Farnesyl pyrophosphate synthase
- Sterol regulatory element-binding protein 1
- Squalene synthase
Sequence:
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
Protein: Cyclic GMP-AMP synthase (c-GAMP synthase) (c-GMP-AMP synthase) (EC 2.7.7.-) (3'3'-cGAMP synthase) (CD-NTase001) (Ec-DncV) (Q6XGD8)
Organism: Escherichia coli
Function: CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type II-C(GA) CBASS system.
Interaction partners:
Sequence:
MPWDFNNYYSHNMDGLISKLKLSKTESDKLKALRQIVRERTRDVFQEARQVAIDVRRQALTLESVRLKLEKTNVRYLSPEERADLARLIFEMEDEARDDFIKFQPRFWTQGSFQYDTLNRPFHPGQEMDIDDGTYMPMTVFESEPSIGHTLLLLLVDTSLKSLEAENDGWVFEEKNTCGRIKIYREKTHIDVPMYAIPKEQFQKKQTAADSAHLIKSDSVFESFALNRGGREAYAVESDKVNLALREGVRRWSVSDPKIVEDWFNESCKRIGGHLRSVCRFMKAWRDAQWEVGGPSSISLMTAVVNILDRESHNGSDLTGTMKLIARLLPEEFNRGVESPDDTDEKPLFPAESNHNVHHRAIVETMEGLYGILLAAEQSESREEALRKINEAFGKRVTNALLITSSAAAPAFLNAPSKEPSSKPINKTMVSG
Protein: Hydroxysteroid 17-beta dehydrogenase 4 (A0A2R8YD50)
Organism: Homo sapiens (Human)
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Interaction partners:
Sequence:
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKVYGR
Protein: Nck-associated protein 1 (NAP 1) (B0S6R1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). Plays a role in neural tube closure.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.
Interaction partners:
- Probable protein BRICK1
- Abl-interactor 1a
- Cytoplasmic FMR1-interacting protein
- Cytoplasmic FMR1-interacting protein 1 homolog
- WASP family member 3b.
- Abl-interactor 1b.
- WASP family member 2.
- WASP family member 1.
- Wiskott-Aldrich syndrome protein family member
- Wiskott-Aldrich syndrome protein family member
Sequence:
MSRGAMQPSQQKLAEKLTILNDRGIGMLTRIYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDACQVFFDITVNFDLTKNYLDLVVTYTTLMLLLSRIEERKAIIGLYNYAHEMTHGSSDREYPRLGQMIVDYENPLKKMMEEFVPHGKSLSDALVSLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLSLDTMEKWIVFGFILCHAALNSDPAALSLWKLALQSSTCLCLFRDEVFHIHKAAEDLFVNIRGYNKRVNDIRECKESALSHAGSMHRERRKFLRSALKELATVLADQPGLLGPKALFVFMALSFARDEIIWLLRHADNIQKKSTDDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSISFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLLVTNLDKLHTALSELCFSINYVPNMMVWEHTFTPREYLTSHLEIRFTKSIVGMTMYNQTTQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVDNVEVLTQMRTSFDKPDHMAALFKRLTSVDSVLKRMTIIGVILSFRSLAQEALRDVLSCHIPFLVSSVEDFKDHIPRETDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSMPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVSSSA
Protein: IE (Q5NTY3)
Organism: Equid alphaherpesvirus 1 (Equine herpesvirus 1)
Subcellular location: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
Interaction partners:
Sequence:
MASQRSDFAPDLYDFIESNDFGEDPLIRAASAAEEGFTQPAAPDLLYGSQNMFGVDDAPLSTPAVVIPPPSPTPEPRGGKAKRSPSAAGSGGPPTPAAAAQPASPAPSPAPGLAAMLKMVHSSVAPGNGRRATGSSSPGGGDAADPVALDSDTETCPGSPQPEFPSSASPGGGSPAPRVRSISISSSSSSSSSMDEDDQADGAGASSSSSSSSDDSDSDEGGEEETPRPRHSQNAAKTPSAAGSPGPSSGGDRPAAGAATPKSCRSGAASPGAPAPAPASAPAPSRPGGGLLPPGARILEYLEGVREANLAKTLERPEPPAGMASPPGRSPHRLPKDQRPKSALAGASKRKRANPRPIPQTQTQAPAEEAPQTAVWDLLDMNSSQATGAAAAAASAPAAASCAPGVYQREPLLTPSGDPWPGSDPPPMGRVRYGGTGDSRDGLWDDPEIVLAASRYAEAQAPVPVFVPEMGDSTKQYNALVRMVFESREAMSWLQNSKLSGQDQNLAQFCQKFIHAPRGHGSFITGSVANPLPHIGDAMAAGNALWALPHAAASVAMSRRYDRTQKSFILQSLRRAYADMAYPRDEAGRPDSLAAVAGYPAQAAAAAASQQQPEAPAPSVRVREAYTRVCAALGPRRKAAAAAAAPGTRAPRPSAFRLRELGDACVLACQAVFEALLRLRGGASAVPGLDPSEIPSPACPPEALCSNPAGLETAALSLYELRDLVERARLLGDSDPTHRLGSDELRLAVRAVLVVARTVAPLVRYNAEGARARASAWTVTQAVFSIPSLVGGMLGEAVSLLAPPTRSQQPSSSSPGGEPFSGSAAAEGSLQTLPPLWPTVPGKQSATVPSSHSQSPQHSQSGGGAGATTATCCRATQTNARSRGQQHQPQKARSPQAAASPAHLSQEAMPGSSSDDRAIHGRPRGKSGKRRSEPLEPAAQAGASASFSSSARGYDPSGPVDSPPAPKRRVATPGHQAPRALGPMPAEGPDRRGGFRRVPRGDCHTPRPSDAACAAYCPPELVAELIDNQLFPEAWRPALTFDPQALATIAARCSGPPARDGARFGELAASGPLRRRAAWMHQIPDPEDVKVVVLYSPLQDEDLLGGLPASRPGGSRREPLWSDLKGGLSALLAALGNRILTKRSHAWAGNWTGAPDVSALNAQGVLLLSTGDLAFTGCVEYLCLRLGSARRKLLVLDAVSTEDWPQDGPAISQYHIYMRAALTPRVACAVRWPRERHLSRAVLTSSTLFGPGLFARAEAAFARLYPDSAPLRLCRSSNVAYTVDTRAGERTRVPLAPREYRQRVLPDYDGCKDMRAQAEGLGFHDPDFEEGAAQSHRAANRWGLGAWLRPVYLACGRRGAGAVEPAELLIPELLSEFCRVALLEPDAEAEPLVMPITEAPRRRAPRVEWEPGFGQRSTSVLHMGALELCLPESDDELEIDGPGDVELVADHPGVSPAAQLIRRAPIKIEVVSDEEDGEDWCNPYLT