wanglab/gogpt-training-data huggingface dataset:
Protein: O-methyltransferase cicE (EC 2.1.1.-) (Cichorine biosynthesis cluster protein E) (A0A1U8QH20)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of cichorine, a phytotoxin active against knapweed, corn, and soybeans. The first step in the pathway is performed by the non-reducing polyketide synthase pkbA that condenses one acetyl-CoA starter unit with 3 malonyl-CoA units. PkbA also catalyzes one methylation step to produce 3-methylorsellinate. The nonribosomal peptide synthase-like protein cicB, the cytochrome P450 monooxygenase cicH and the O-methyltransferase cicE are involved in the conversion of 3-methylorsellinate into nidulol. CicB converts 3-methylorsellinate to a yet unidentified intermediate, cicH may play a ring-closing role for cichorine and cicE is plausibly responsible for the methylation of one of the phenol groups (Probable). The oxidoreductase cicC acts downstream with still unidentified enzymes to further convert nidulol into cichorine.
Interaction partners:
Sequence:
MERFPRSAADAQQLLQLAELFKQSAEIIAEEWNKEDFSRIKAETNSIKSNLGSLDTARILPSPRLHEATRTVLAITGAATELVAEPYSRIQEVACQYFESRALFVAAERRIPDLLAGAGEYGLSVGEIAEATGIEERKLSRILRCLCSIHIFRQIGTDRFANNRISAALKNNEPLRAYVQLFNLDIYTASDQLPKYLLSSQGASYKVHETAWQKAVGTTKARWDWLAERVSLDEVRPKEAPYPGLPDVRHLQPGPDGKYARPELDNFGLAMVGGGKVSGAAHAYDFPWASLGDALVVDVGGGVGGFVLQLLPAYPQLRYIVQDRAEVLQQAQEEIWPVEAPEAVADGRVQFMEHNFFQPNPVKGADVYWLRGIFYCVQILSALRTSMAPTSRILVCDQVMNTTAGCDEIPPAPSPLPANYGYYMRYPHHRDLAMMSIINGIERTPAQFTELVKQAGLKVNKIWNCRSMVGIVEIGLKNEKDRHHRRLSYMGFGNYTQLGIGFFSSAKGPVRDELQADEQA
Protein: Protein argonaute-4 (Argonaute4) (mAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4) (Piwi/argonaute family protein meIF2C4) (Q8CJF8)
Organism: Mus musculus (Mouse)
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.
Subcellular location: Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03033}.
Interaction partners:
- Protein argonaute-1
- Endoribonuclease Dicer
- Protein argonaute-2
- Trinucleotide repeat-containing gene 6A protein
- RISC-loading complex subunit TARBP2
- Protein argonaute-3
- Ribonuclease 3
- Trinucleotide repeat-containing gene 6C protein
- Microprocessor complex subunit DGCR8
- Exportin-5
Sequence:
MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRIDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKHPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPSQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKMNAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEITQELLYSQEVVQDLTSMARELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKMERVGKSGNVPAGTTVDSTVTHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA
Protein: Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) (Q15906)
Organism: Homo sapiens (Human)
Function: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Subcellular location: Nucleus {ECO:0000305|PubMed:26974126}.
Interaction partners:
- DNA methyltransferase 1-associated protein 1
- RuvB-like 1
- YEATS domain-containing protein 4
- RuvB-like 2
- Histone H2A.Z
- Helicase SRCAP
- Transformation/transcription domain-associated protein
- Histone acetyltransferase KAT5
- Zinc finger HIT domain-containing protein 1
- Mortality factor 4-like protein 1
Sequence:
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPAPSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK
Protein: At5g65790 (MYB transcription factor) (Myb - related protein) (Myb domain protein 68) (Transcription factor-like protein) (O49538)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRAPCCDKANVKKGPWSPEEDAKLKDYIENSGTGGNWIALPQKIGLRRCGKSCRLRWLNYLRPNIKHGGFSEEEDNIICNLYVTIGSRWSIIAAQLPGRTDNDIKNYWNTRLKKKLLNKQRKEFQEARMKQEMVMMKRQQQGQGQGQSNGSTDLYLNNMFGSSPWPLLPQLPPPHHQIPLGMMEPTSCNYYQTTPSCNLEQKPLITLKNMVKIEEEQERTNPDHHHQDSVTNPFDFSFSQLLLDPNYYLGSGGGGEGDFAIMSSSTNSPLPNTSSDQHPSQQQEILQWFGSSNFQTEAINDMFINNNNNIVNLETIENTKVYGDASVAGAAVRAALGGGTTSTSADQSTISWEDITSLVNSEDASYFNAPNHV
Protein: Plasmanylethanolamine desaturase 1 (EC 1.14.19.77) (Transmembrane protein 189) (Q99LQ7)
Organism: Mus musculus (Mouse)
Function: Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:32209662}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ethanolaminephosphotransferase 1
- Choline/ethanolaminephosphotransferase 1
- 5'-3' exonuclease PLD4
- Phospholipase D2
- Lysophospholipid acyltransferase LPCAT4
- Group 3 secretory phospholipase A2
- Cytosolic phospholipase A2 epsilon
- Group IIE secretory phospholipase A2
- Cytosolic phospholipase A2 gamma
- Cytosolic phospholipase A2 beta
Sequence:
MAGAEDAPGRQPELDEDETAEGRRWGAQHAGARELAALYSPGKRFQEWCSVILCFSLIAHNLVHLLLLARWEHTPLVILGVVAGALVADFLSGLVHWGADTWGSVDLPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTQSPETLEQLYPWECFVFCLTIFGTFTNQIHKWSHTYLGLPYWVTVLQDWHVILPRKHHRIHHVAPHETYFCITTGWLNYPLEVIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q9C9X1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- At1g12450
- AT hook motif-containing protein
- Serine carboxypeptidase-like 3
- Eukaryotic translation initiation factor 2A
- Probable disease resistance protein At5g43740
- Probable phospholipid-transporting ATPase 11
- DNA repair DEAD helicase RAD3/XP-D subfamily protein
- L-ascorbate oxidase
- Disease resistance like protein
- Heavy metal-associated isoprenylated plant protein 42
Sequence:
MSSPESPSGSDSSTPLLRSRQSSPRRQPVIAVLLNRASGRRGASMVVRETAAQELEERRADWGYSKPVVALDMLWNTAFVLVAIVMLLVFKEEKPNVPIRIWICGYAIQCLVHVVLVWLEFRKRNARSRPGDLEAAQATNQDSEDEDNDERFLSTKTCESMNTIISFVWWIVGFYWLVSGGDILLQNATHLYWLTFVFLAFDVFFAIFCVVLACLIGIALCCCLPCIIALLYAVAGQEGASEADLSILPKYRFHTMNNDEKQSDGGGKMIPVDAASENLGNERVLLPEDADCCICLSSYEDGAELVSLPCNHHFHSTCIVKWLKMNATCPLCKFNILKGNEQE
Protein: Urease subunit alpha (EC 3.5.1.5) (Urea amidohydrolase subunit alpha) (P18314)
Organism: Klebsiella aerogenes (Enterobacter aerogenes)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01953}.
Interaction partners:
Sequence:
MSNISRQAYADMFGPTVGDKVRLADTELWIEVEDDLTTYGEEVKFGGGKVIRDGMGQGQMLAADCVDLVLTNALIVDHWGIVKADIGVKDGRIFAIGKAGNPDIQPNVTIPIGAATEVIAAEGKIVTAGGIDTHIHWICPQQAEEALVSGVTTMVGGGTGPAAGTHATTCTPGPWYISRMLQAADSLPVNIGLLGKGNVSQPDALREQVAAGVIGLKIHEDWGATPAAIDCALTVADEMDIQVALHSDTLNESGFVEDTLAAIGGRTIHTFHTEGAGGGHAPDIITACAHPNILPSSTNPTLPYTLNTIDEHLDMLMVCHHLDPDIAEDVAFAESRIRRETIAAEDVLHDLGAFSLTSSDSQAMGRVGEVILRTWQVAHRMKVQRGALAEETGDNDNFRVKRYIAKYTINPALTHGIAHEVGSIEVGKLADLVVWSPAFFGVKPATVIKGGMIAIAPMGDINASIPTPQPVHYRPMFGALGSARHHCRLTFLSQAAAANGVAERLNLRSAIAVVKGCRTVQKADMVHNSLQPNITVDAQTYEVRVDGELITSEPADVLPMAQRYFLF
Protein: Selenoprotein (C0Z3M5)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKAYYVVIILKVVLLLFFSYDFIFLKNEDNIIKGKGSSFLKSSYELLFVQKDVLLPHIKKNNQISIFLCRSUQSQYIINKIKNYFDILNKGRETEIYFENNNYIVDNDQKYILFLMSIQPPLFFTLICYFILFIFILIALNIYLPKHCEFFIPSFLLNNTKFIETFEKMRKKKIIVSSIMFLAYNIIYSILCNTNEIHVYQNKNLIYKDYFNEYFFIQTLRTNLKNIHK
Protein: Sphinganine C4-monooxygenase 2 (EC 1.14.18.5) (Sphingoid C4-hydroxylase 2) (Sphingoid base hydroxylase 2) (Q9AST3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in sphingolipid trihydroxy long-chain base (4-hydroxysphinganine) biosynthesis. Can use C18- and C20-sphinganine as substrates to produce C18- and C20-phytosphinganines (D-ribo-2-amino-1,3,4-trihydroxyoctadecane and -eicosane).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18612100}; Multi-pass membrane protein {ECO:0000269|PubMed:18612100}.
Interaction partners:
- 3-dehydrosphinganine reductase TSC10A
- 3-dehydrosphinganine reductase TSC10B
- Alkaline ceramidase
- Dihydroceramide fatty acyl 2-hydroxylase FAH2
- Delta
- Delta
- Sphingosine kinase 1
- Sphingosine kinase 2
- Neutral ceramidase 1
- Ceramide synthase LOH2
Sequence:
MMSFVISDEFLGTFVPILVYWVYSGMYICLGSLDKYRLHSKIDEDEKNLVSKSAVVKGVLLQQTLQAIISVILFKITGSDADAATTQQFSILLLARQFIIAMLVIDTWQYFIHRYMHLNKFLYKHIHSQHHRLIVPYSYGALYNHPLEGLLLDTIGGALSFLFSGMSPRTAIFFFSFATIKTVDDHCGLWLPGNPFHIFFSNNSAYHDVHHQLYGTKYNFSQPFFVMWDRILGTYLPYSLEKRANGGFETRPIKVSKDE
Protein: DSC E3 ubiquitin ligase complex subunit 4 (Defective for SREBP cleavage protein 4) (O14175)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:21504829}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- DSC E3 ubiquitin ligase complex subunit 2
- DSC E3 ubiquitin ligase complex subunit 3
- DSC E3 ubiquitin ligase complex subunit 1
- Uncharacterized protein new13
- UBX domain-containing protein 10
Sequence:
MDTIVLDQRGEVFSFFRSLDMLCYAIIAQQYFQDPTVLLLLLKVFVQLSYLTPKPFSQLNALPLFYPLLLNFLISLMVRMFFNLPTAGESLDGYLYGGSIINFIGEKNESSRIDFITSDLVLFCLQIFMALILIASNKRPTQASHIQASQSGLSNVDGDEEPSDLITEDSRDTQQGQRQEDLQRQLENERSRLIARFSHSLYSFQHGLSFGSPQNRNTPLQRQSADSYSTPVCIEVDSEDWKDLVWKSQYATENANTNSINNSPLSSNTTGVPNSVLTNPI
Protein: BSD domain-containing protein (Q57XW3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein kinase domain-containing protein
Sequence:
MWFTNITKDIGEITSSFVEDTRNLANIVTRFATEVTGGNVLIAGDEDSRLAQQCPLSDTDIASFQRNSMVFLDDISEDEKASFDVWAKESEFKSQPLPQRREGHAELLPGSRYEKLATFRQQLLDTNPFVKKRYAAFVLSDERRHQKGGAEAIEHKRDEQVDTAAEHMEKDEIAPLDETLRITEDVFFDRYFFRLSQLRLRLAAERKQREEATKKEELEVNGVDQWSKGGLKAFTQRIVEAADGLINWDDENRERSGESQRTKSECETQENTIAALQSVVQALQSELWSEKRKLAAVLEVARNCGLSEEQQRLLREAAQNEEHSGNAPVRSSVCELELTGSGRKSMSVRSKGGDKESRGGSVDCKESRKNEDGADGNVKVSSKAASEGDNNESSSGVQFFVDNDGWTNVK
Protein: Small ribosomal subunit protein uS5c (30S ribosomal protein S5, chloroplastic) (P93014)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds directly to 16S ribosomal RNA.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS9c
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS26z
- Small ribosomal subunit protein eS26y
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- Small ribosomal subunit protein eS26x
- Small ribosomal subunit protein uS4c
- Small ribosomal subunit protein uS13c
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS17c
Sequence:
MATASALSSLSSLSLHTRTSSLISSSSTKSIVSFSSFLNRRFSSLTLVKASSTDTETIFFEDETPEITANVVFDPPIAPEGFVSPPYFDEGSDETEEEIATAFEELYGPAYSGESMLGKDIYVMDSKHKKSSGIGGKPKKDKIRDGFEERVVQVRRVTKVVKGGKQLKFRAIVVVGDKQGNVGVGCAKAKEVVAAVQKSAIDARRNIVQVPMTKYSTFPHRSEGDYGAAKVMLRPASPGTGVIAGGAVRIVLEMAGVENALGKQLGSNNALNNARATLAAVQQMRQFRDVAQERGIPMEELWK
Protein: Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) (Q53GS9)
Organism: Homo sapiens (Human)
Function: Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178}.
Interaction partners:
- U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
- Probable ATP-dependent RNA helicase DDX23
- U4/U6 small nuclear ribonucleoprotein Prp3
- 116 kDa U5 small nuclear ribonucleoprotein component
- U4/U6 small nuclear ribonucleoprotein Prp31
- Pre-mRNA-processing-splicing factor 8
- U6 snRNA-associated Sm-like protein LSm4
- Small nuclear ribonucleoprotein Sm D2
- U6 snRNA-associated Sm-like protein LSm2
- U6 snRNA-associated Sm-like protein LSm8
Sequence:
MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAREAPASVVPFVRVKREREVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDFEKLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEIIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQGA
Protein: Bone morphogenetic protein 15 precursor (Bone morphogenetic protein-15) (Q58FS4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKATSGPNGLRLCVLSCLFVLHIFTRVAGNMASPSHFGVASTEVHRNRHPKRRNPHFRPPVESRTDDDGMRLMLSLYRIAADADGRPKQHKIFGSNTIRLLQASTTEKHFPPTSSDLQYTYTVKYELNDLLLDKLVKASFMYLRSPMSSRLPYICEASVTSLQNPLEGDRITMGPRSRWTETDVTDHVSESKDGHVSFFARYWCTKPEHKRSVAHRKRFPPQHHLRAPLLLLFLEENKHPVEWGKSFPPLSRPRTRRSKKSGSIVSDIPNFKQGLNRVTKNNCKLYSSSVDFKDLGWDHWVIAPHKYNPGYCMGDCPRILHYGYNSPNHAIMQTFISELGVADIPLPSCVPYKYKRMSMLVMGSNGQIDYKEYEDMIADSCTCR
Protein: Large ribosomal subunit protein eL33B (60S ribosomal protein L33-B) (L37) (RP47) (YL37) (P41056)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL6A
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein eL6B
- Large ribosomal subunit protein eL30
- Ribosome biogenesis protein NOP53
- Large ribosomal subunit protein eL14A
- Large ribosomal subunit protein eL20A
- Large ribosomal subunit protein eL38
- Small ribosomal subunit protein eS21B
Sequence:
MAESHRLYVKGKHLSYQRSKRVNNPNVSLIKIEGVATPQEAQFYLGKRIAYVYRASKEVRGSKIRVMWGKVTRTHGNSGVVRATFRNNLPAKTFGASVRIFLYPSNI
Protein: Ribosome biogenesis protein nsa2 (Q9UU79)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Nucleolar GTP-binding protein 2
- Probable nucleolar GTP-binding protein 1
- Ribosome biogenesis protein rlp24
- Eukaryotic translation initiation factor 6
- Ribosome assembly factor mrt4
- Ribosome biogenesis protein nsa1
- Pescadillo homolog
- Large ribosomal subunit protein eL31
- Ribosome biogenesis protein erb1
- Ribosome biogenesis protein ytm1
Sequence:
MPQNEYIEESIRKHGRRFDHEERKRKKAAREAHDASLYAQKTRGIKAKLYQEKRRKEKIQMKKTIKQHEERNATQRGSDAQTQGAVPTYLLDREQESQAKMLSSAVKQKRKEKAAKYSVPLPQVRGVAEEEMFKVIRTGKSKKNSWKRMITKATFVGDGFTRRPVKYERFIRPMALRQKKANVTHKELGVTMQLPIIGVKKNPQSPTYTQLGVLTKGTVIEVNVSELGLVTSGGKVVWGKYAQITNNPELDGCVNALLLT
Protein: LP14331p (Multi drug resistance 50 (EC 3.6.1.3)) (Q5BI62)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Enhancer of split m4 protein
- Multidrug resistance protein homolog 49
- Multidrug resistance protein homolog 65
- Uncharacterized protein, isoform A
- Sodium/potassium-transporting ATPase subunit alpha
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit beta-2
Sequence:
MTVKNGDVVKDDVNSRSQYKTNIVLGAKLEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQSGAM
Protein: Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1) (Q8N257)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H4
- Histone H3.2
- Histone H3.1
- Histone H2A type 1-B/E
- Core histone macro-H2A.1
- Histone H3.1t
- Histone H3.3
- Histone H2A type 2-C
- Histone H2A.Z
- HLA class II histocompatibility antigen, DRB1 beta chain
Sequence:
MPDPSKSAPAPKKGSKKAVTKAQKKDGKKRKRGRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Protein: Translocating chain-associated membrane protein 1 (Protein TRAM1) (Q91V04)
Organism: Mus musculus (Mouse)
Function: Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel. Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21237175}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Translocating chain-associated membrane protein 1-like 1
Sequence:
MAIRKKSNKNPPLLSHEFLLQNHADIVSCLAMLFLLGLMFEVTAKGAIIFVALQYNVTRPATEEQATESASLYHYGIKDLATVLFYMLVAIIIHAIIQEYVLDKINRRMHFSKTKHSKFNESGQLSAFYLFACVWGTFILISENYISDPTILWRAYPHNLMTFQTKFFYISQLAYWLHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSDEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICITQAFMMWKFINFQLRRWREHSAFQAPPVKRKPAVTKGRSSRKGTENGVNGTVTSNGADSPRNRKEKSS
Protein: Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (Roadblock domain-containing protein 3) (Q9JHS3)
Organism: Mus musculus (Mouse)
Function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:11266467, ECO:0000269|PubMed:15263099, ECO:0000269|PubMed:19177150}; Peripheral membrane protein {ECO:0000269|PubMed:19177150}; Cytoplasmic side {ECO:0000269|PubMed:19177150}. Lysosome membrane {ECO:0000269|PubMed:11266467}; Peripheral membrane protein {ECO:0000269|PubMed:19177150}; Cytoplasmic side {ECO:0000269|PubMed:19177150}. Note=Recruited to lysosome and endosome membranes by LAMTOR1. {ECO:0000269|PubMed:19177150}.
Interaction partners:
- Ragulator complex protein LAMTOR3
- Ragulator complex protein LAMTOR5
- Ragulator complex protein LAMTOR1
- Ragulator complex protein LAMTOR4
- Neutral amino acid transporter 9
- Ras-related GTP-binding protein C
- Ras-related GTP-binding protein A
- Ras-related GTP-binding protein B
- Ras-related GTP-binding protein D
- Regulatory-associated protein of mTOR
Sequence:
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDSLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS