wanglab/gogpt-training-data huggingface dataset:
Protein: Na/Ca-exchange protein, isoform E (A0A0B4K790)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MQLLLKSIFTCALFVIFVYATAQSLLKVQETEARQAYLNVTSSSSSNLSQDDGHFLSRRLRQVSHGEEGDEGAPSQMDDELEQMTKVHGEAPDAEELRECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNKRGTVVAGEHDQVEMDAEKGPKQPMVTSARGNDAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDTNKESFFNRFFDDELAAKIKEVEKKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVICILEAYDVIRV
Protein: Exosome complex component CSL4 (CEP1 synthetic lethal protein 4) (P53859)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Exosome complex exonuclease DIS3
- Exosome complex component RRP42
- Exosome complex exonuclease RRP6
- Exosome complex component RRP4
- Exosome complex component RRP40
- Exosome complex component RRP46
- Superkiller protein 7
- M-phase phosphoprotein 6 homolog
- Exosome complex component SKI6
- Exosome complex component RRP45
Sequence:
MACNFQFPEIAYPGKLICPQYGTENKDGEDIIFNYVPGPGTKLIQYEHNGRTLEAITATLVGTVRCEEEKKTDQEEEREGTDQSTEEEKSVDASPNDVTRRTVKNILVSVLPGTEKGRKTNKYANNDFANNLPKEGDIVLTRVTRLSLQRANVEILAVEDKPSPIDSGIGSNGSGIVAAGGGSGAATFSVSQASSDLGETFRGIIRSQDVRSTDRDRVKVIECFKPGDIVRAQVLSLGDGTNYYLTTARNDLGVVFARAANGAGGLMYATDWQMMTSPVTGATEKRKCAKPF
Protein: Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) (Q61177)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369118}.
Interaction partners:
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMSSTSMAGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANSLGIPVPAAACAQQ
Protein: Apelin (APJ endogenous ligand) [Cleaved into: Apelin-36; Apelin-31; Apelin-28; Apelin-13] (Q9R0R3)
Organism: Rattus norvegicus (Rat)
Function: Endogenous ligand for the apelin receptor (APLNR). Drives internalization of the apelin receptor. Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR. Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior.
Subcellular location: Secreted {ECO:0000269|PubMed:10525157}. Secreted, extracellular space {ECO:0000269|PubMed:10525157}. Note=Abundantly secreted in the colostrum (By similarity). Lower level in milk (PubMed:10525157). Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk (By similarity). {ECO:0000250|UniProtKB:Q9TUI9}.
Interaction partners:
- Apelin receptor
- Angiotensin-converting enzyme 2
- Insulin-1
- Insulin-2
- Coagulation factor XIII A chain
- Angiotensinogen
- Resistin-like gamma
- Resistin
- Nicotinamide phosphoribosyltransferase
Sequence:
MNLSFCVQALLLLWLSLTAVCGVPLMLPPDGKGLEEGNMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF
Protein: At1g76060 (LYR family of Fe/S cluster biogenesis protein) (Q63Z96)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MMAAKLQKWRNLAGRLDLMNRSGAVSTRRFLHEGPDTVEELLERHLAKKEKPIIDHDEAEFLNRRRLTSTRREALSLYRDILRATRFFTWIDSRGNLWRDVLRENARKEFEAARFETDPEVITRLLIGGSDAVSSALDKLAEKQREMIEKQRRGDQR
Protein: Fizzy-related protein (O18402)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFSPEYQKRILKHYSPVARNLFNNFESSTTPTSLDRFIPCRAYNNWQTNFASINKSNDNSPQTSKKQRDCGETARDSLAYSCLLKNELLGSAIDDVKTAGEERNENAYTPAAKRSLFKYQSPTKQDYNGECPYSLSPVSAKSQKLLRSPRKATRKISRIPFKVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWNVFSKARSQKENKSVLNLFANIR
Protein: Lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.3.9) (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase) (Ganglioside GM3 synthase) (ST3Gal V) (Sialyltransferase 9) (A0JMC3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Interaction partners:
Sequence:
MRRVMKQSSCYFSKRTMILLLSLALMSLAFLKLPSFHTELKPVEVPVDNKFRKRVHSHVREILDKECRPSFARQRMVTEHHGSTPTIDPFLNKNMKLDKQIFQYPPPFGFLDMKNKLEEILNLLPVSSEQRLGERDCRRCVVVGNGGILKGLGLGHLLNRFDIIIRLNSGPLQDFSADVGNRTTIRMSYPESCPKVWEDTDPDLKYVAVIFKSVDFHWLRAMISRTPVSLWDRLFFWQNVPMSVPVKTSQFHLLNPQIIREMALDLLNYPEPKKRLWSWDQNIPTLGLTALNLATYICDEVSLAGFGYNLSQKEAPLHYYDSVPMTTILKEAMHNVQKETVFLKRLVASGSITDLTGGIHCSFC
Protein: Fatty acyl-CoA reductase (EC 1.2.1.84) (D2SNU9)
Organism: Heliothis virescens (Tobacco budworm moth)
Interaction partners:
Sequence:
MVVLTSKETKPSVAEFYAGKSVFITGGTGFLGKVFIEKLLYSCPDIVNIYMLIREKKGLSVSERIKQFLDDPLFTRLKDKRPADLEKIVLIPGDITAPDLGITAANEKMLIEKVSVIIHSAATVKFNEPLPTAWKINVEGTRMMLALSRRMKRIEVFIHISTAYTNTNREVVDEILYPAPADIDQVYQYVKEGISEEDTEKILNGRPNTYTFTKALTEHLVAENQAYVPTIIVRPSVVAAIKDEPLKGWLGNWFGATGLTVFTAKGLNRVIYGHSNYIVDLIPVDYVANLVIAAGAKSNTSSELKVYNCCSSSCNPVKIGTLMSMFADDAIKQKSYAMPLPGWYIFTKYKWLVLLLTFLFQVIPAYITDLSRHLVGKSPRYIKLQSLVNQTRSSIDFFTNHSWVMKADRVRELYASLSPADKYLFPCDPVNINWTQYLQDYCWGVRNFLEKKT
Protein: Protein DNA-DAMAGE INDUCIBLE 1 (EC 3.4.23.-) (Q1EBV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor of ubiquitinated protein targeted to ubiquitin/proteasome-mediated proteolysis (UPP). Relatively weak affinity for both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains with a slight preference for 'Lys-48-'linked chains of three or more ubiquitin units.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5TDH0}.
Interaction partners:
- Probable ubiquitin receptor RAD23a
- Ubiquitin receptor RAD23d
- Ubiquitin receptor RAD23c
- Ubiquitin receptor RAD23b
- Ubiquitin domain-containing protein DSK2b
- Ubiquitin-ribosomal protein eS31x fusion protein
- Ubiquitin-ribosomal protein eS31y fusion protein
- Ubiquitin-ribosomal protein eS31z fusion protein
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- Ubiquitin domain-containing protein DSK2a
Sequence:
MRITVMTAGEQIITLDVDSQETVENVKALLEVESNVPIQQQQLLYNGNEMGNSDKLSALGVKDDDLLMMMVSNASSGSATSAAGNDLGMNPDGSALNPAAFQQHIRGDSNLMGQLFQNDPELAQVISGSDLNKLQDVLRARHRQRSVLQRQKEEELALLYADPFDVEAQRKIEAAIRQKGIDENWEAALEHNPEGFARVIMLYVDMEVNGVPLKAFVDSGAQSTIISKSCAERCGLLRLMDQRYKGIAHGVGQTEILGRIHVAPIKIGNNFYPCSFVVLDSPNMEFLFGLDMLRKHQCTIDLKENVMTVGGGEVSVPFLQEKDIPSRFLDEERVPNDASSSGATVPSGFTEKKNNTVANPTSQQPKRQNTSEGPEFEAKIAKLVELGFSRDSVIQALKLFEGNEEQAAGFLFGG
Protein: Bilobe protein, conserved (Q57W72)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKYSGDTPVADDEAVDKLRGELVDLQKRFILLFKASGQSLEQIRSTVESSLKSRANEPTQGGRLSDRDSMLQDLVRIVERTQRYVQLAGKPPLGSVSADALQIEYQSWASNMPTASSHRSHGDHATTEQRVKSLQLERDDVKRKLQEAEENNAKLQRKLKAAVQKYNHLAKNTKEMGEPSHTTRARTLSPSAHNGNSSKSSEAVSKRFTGHSYRDSAGQRSCRQNSCNDVVGDSAFNSQHTSARGGSSEFLDAVRQDNASLRREVTKLKEELRQTQRGAIARTKQGDEDVGSLLMKITGLKQELVLEERQRMDALLHLGEAKRENQRLVTQVEELKQQLVHVQQSDGRVPDVISVESKETNIMNSLGKELGHTQQVAAMQVLQAKELTRVLERMQDFLHSSFLKQRKLVTELEKAGKGWSTTPLQLEAAQTHEGCTPANKVKIEDANVSSPGVESSGGKSRTILKASDDSGSSDLNTFCDRVLTVDDVDPLTLGKNDGDTHLRSQNSELVKENQQLHDALSKLSMMYRSTKEKPKSGERSVMEREALPPGVKQPDRSAEVASAKRVVKEHVRKDNAKAHRDAKKEKAQSSLREQVPPKQLPVQPHQLPKAPKPQAQRDLPPKSPVRRHDSHLQRSRTTTPRREAHAQYDQKQRHNLSSSLQAETGYTQSPSASQSRDDRSSSHSSTSTARFLRRLAEFRFPKEGAASVPDSGERNTDSGKDDVRNFSPPRLSYMKST
Protein: Keratin 76 (A0A8I6ABD6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MESLLQPLNVEIDPQIGQVKAQEREQIKILNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTRSGSGPLNLESFFESYISCLRKQLDSLLGAKGSLQGELKSMQDLVEDFKRKYEEEINRRTTAENEFVALKKDVDGAYMSKVELQAKVDSLTDEINFLRTLYDMELSQMQSHISDTSVVLSMDNNRCLDLDSIIAEVKAQYEDIAQRSKAEAEALYQTKLGELQTTAGRH
Protein: Probable inactive ATP-dependent zinc metalloprotease FTSHI 4, chloroplastic (AtFTSHI4) (Protein EMBRYO DEFECTIVE 3144) (Protein FTSH INACTIVE PROTEASE 4) (F4KF14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions in chloroplast biogenesis and chloroplast division. Required for plastid development during embryogenesis. Might be involved in chaperone functions or play a structural role in the thylakoid FtsH complex.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:24964212}; Single-pass membrane protein {ECO:0000269|PubMed:24964212}.
Interaction partners:
- ATP-dependent zinc metalloprotease FTSH 12, chloroplastic
- Protein Ycf2
- Probable inactive ATP-dependent zinc metalloprotease FTSHI 2, chloroplastic
- Probable inactive ATP-dependent zinc metalloprotease FTSHI 1, chloroplastic
- Probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic
- Malate dehydrogenase, chloroplastic
- Protein TIC 56, chloroplastic
- Protein TIC 100
- AT5g10910/T30N20_180
- Membrane metalloprotease ARASP, chloroplastic
Sequence:
MTFYISSSLTPTHFSKPLNPSNTLFPSQFRGSLSSFVRRRKPTEAKLSSKFNLFPSRRNGLITCCSTSSFESTESSVSQEEDAESNRLFEKLRETERERLSNMEELERKANVQLERQLVMASDWSRTLLTMRGKLKGTEWDPETSHRINFSDFMKLLDSNSVQYMEYSNYGQTISVILPYYKDGEPLGEEEDSKKEIIFRRHIVDRMPIDGWNDVWKKLHQQIVNVEVFNVDVVPAEVYTTVATFVVWSMRLALFVSLYVWIDSITRPIYAKLIPCDLGTPTKKIRQPLKRQALGSLGKSRAKFISAEEKTGVTFDDFAGQEYIKRELQEIVRILKNDEEFQNKGIYCPKGVLLHGPPGTGKTLLAKAIAGEAGLPFFAANGTDFVEMFVGVAASRVKDLFASSRSYAPSIIFIDEIDAIGSKRGGPDIGGGGAEREQGLLQILTEMDGFKVTTSQVLVIGATNRLDILDPALLRKGRFDKIIRVGLPSKDGRLAILKVHARNKFFRSEDEKEELLQEVAENTEDFTGAELQNVLNEAGILTARKDLDYIGREELLEALKRQKGTFETGQEDSTEVPEELKLRLAYREAAVAVLACYLPDQYRPISETDINSIRSQPNMRYSETSGRVFARKSDYVNSIIRACAPRVVEEEMFGIENLCWISAKSTLEASQRAEFLILQTGMTAFGKAYYRNQRDLVPNLVPKLEALRDEYMRFAVEKCSSILQEYQSALEEITDVLLEKGEIKADEIWNIYNTAPRIPQKPVRPVDEYGALIYAGRWGIHGVSLPGRVTFSPGNIGFATFGAPRPMETQIISDDTWKLVDEIWDKKVEEIKAEAVIQIEEEKKKPQILMATHFF
Protein: Phosphatidylinositol-3-phosphate phosphatase MTMR7 (EC 3.1.3.64) (Inositol 1,3-bisphosphate phosphatase) (Myotubularin-related protein 7) (Q9Y216)
Organism: Homo sapiens (Human)
Function: Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16787938}. Endomembrane system {ECO:0000250|UniProtKB:Q9Z2C9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z2C9}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z2C9}. Note=May partially localize to endosomes and/or the Golgi apparatus. {ECO:0000250|UniProtKB:Q9Z2C9}.
Interaction partners:
- Myotubularin-related protein 9
- Polyphosphoinositide phosphatase
- 1-phosphatidylinositol 3-phosphate 5-kinase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Inositol polyphosphate 4-phosphatase type II
- Inositol polyphosphate-4-phosphatase type I A
- Phosphatidylinositide phosphatase SAC2
- Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
- Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
- Phosphatidylinositol 3-kinase catalytic subunit type 3
Sequence:
MEHIRTPKVENVRLVDRVSPKKAALGTLYLTATHVIFVENSPDPRKETWILHSQISTIEKQATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYEELYCFSFNPMLDKEEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLSANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
Protein: Glutathione S-transferase 1 (EC 2.5.1.18) (GST class-sigma) (P46436)
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can also function as a GSH peroxidase.
Interaction partners:
Sequence:
MPQYKLTYFDIRGLGEGARLIFHQAGVKFEDNRLKREDWPALKPKTPFGQLPLLEVDGEVLAQSAAIYRYLGRQFGLAGKTPMEEAQVDSIFDQFKDFMAELRPCFRVLAGFEEGDKEKVLKEVAVPARDKHLPLLEKFLAKSGSEYMVGKSVTWADLVITDSLASWESLIPDFLSGHLQLKKYIEHVRELPNIKKWIAERPKTPY
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (B2BJC0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRPKTFPATLYVGNTRQRLQDIKEGLKQPAKLVSQALHGGSSRGEGGRGGDSKGKDQAARQQQLRPPQKFNNYQSALREIRKSLRPYANDSGPGSSSGHPGEVSRQMLQDLVNAGCDQEMAVRALKQTGSRNIEAALEYISKMSYLDPHTEQIVRVIKQTSPGKSGMPNLMDHRTAMEGSGDGALPPYHQMGAPLYEGASYGAEGEMARAYMGGPPVMNYMPPPANPSQGSQPSGGPGAHYDYRSHMMENSSYGVKRSASFQNKMPQLTTENYVNMPSKAAMGQNAGGYAPNLYLPPHSHPRQASPTSHQVHMMQRPPGVAPGAMGGEFSDVPQGLLTPSRASLNLDLYEHHWPGAQGPEGTPPARQPQGPFRGEVRVPSRTNSFNNHQKVTVRQTLPPTASVAGKPESSLGPPNTITAVTSPPIQPPVKSIRVMRPEPKTAVGPCHPGWLSAQSPEAQDSLGYIPDENFTLEPSQEHRCPPPPYPKTLLVSGSGPEPASLEPVAMSGLQDVSATGRTIQSSSVGKQEEPIFKDKVKMGKGEKAVKDKKQIQTSPVPVRKNARDEEKRESRIKSYSPFAFKFYMEQHVENVMKTYQQKLNRRMQLEQEMSKAGLSEAEQEQMRKMLYQKESNYNRLRRAKMDKSMFVKIKTLGIGAFGEVCLTRKVDTGALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVRLYYSFQDRDNLYFVMDYIPGGDMMSLLIRMGVFPEVLARFYVAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHIRQDSMEPSDSWDDVSNCRCGDRLMTLEQRATRQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTEAQLKVINWENTLQVPPQVKLSPEAVDIIGQLCCSAEERLGGNGAGEIKAHPFFSEVDFSSNLRTQPAPYRPKIAHPMDTSNFDPVEEEGGPGAWSDSGDSTRTWDTLCSPHGKHPEHAFYEFTFRRFFDDNGCPFRYPKPLEATQSLSSSDGAGSLKPELEEEEAHEEEEQGEGCEPVYV
Protein: Argonaute (Plant)-Like protein (G5EC94)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSRRNATNFVDNNTLTSSGSGSLSPPITSRPASGQASPLSSNGSLSPPVDDQGSVSYNSDSPRDLSPLLLSELACLNMREVVARPGLGTIGRKIPVKSNFFAVDLKNPKMVVVQYHVEVHHPGCRKLDKDEMRIIFWKAVSDHPNIFHNKFALAYDGAHQLYTVARLEFPDDQGSVRLDCEATLPKDNRDRTRCAISIQNVGPVLLEMQRTRTNNLDERVLTPIQILDIICRQSLTCPLLKNSANFYTWKSSCYRIPTAAGQALDLEGGKEMWTGFFSSAHIASNYRPLLNIDVAHTAFYKTRITVLQFMCDVLNERTSKPNRNNPRGPGAPGGYRGGRGGARGGSYQNFGNRGPPGANVRDDFGGNGLTFTMDTLSRDTQLSSFETRIFGDSIRGMKIRATHRPNAIRVYKVNSLQLPADKLMFQGIDEEGRQVVCSVADYFSEKYGPLKYPKLPCLHVGPPTRNIFLPMEHCLIDSPQKYNKKMTEKQTSAIIKAAAVDATQREDRIKQLAAQASFGTDPFLKEFGVAVSSQMIETSARVIQPPPIMFGGNNRSINPVVFPKDGSWSMDHQTLYMPATCRSYSMIALVDPRDQTSLQTFCQSLTMKATAMGMNFPRWPDLVKYGRSKEDVCTLFTEIADEYRVTNTVCDCIIVVLQSKNSDIYMTVKEQSDIVHGIMSQCVLMKNVSRPTPATCANIILKLNMKMGGINSRIVADQITNKYLVDQPTMVVGIDVTHPTQAEMRMNMPSVAAIVANVDLLPQSYGANVKVQKKCRESVVYLLDAIRERIITFYRHTKQKPARIIVYRDGVSEGQFSEVLREEIQSIRTACLAIAEDFRPPITYIVVQKRHHARIFCKFPNDMVGKAKNVPPGTTVDTGIVSPEGFDFYLCSHYGVQGTSRPARYHVLLDECKFTADEIQNITYGMCHTYGRCTRSVSIPTPVYYADLVATRARCHIKRKLGLADNNDCDTNSLSSSLASLLNVRTGSGKGKKSHAPSVDDESYSLPDAASDQILQDCVSVAADFKSRMYFI
Protein: Mut7-C RNAse domain-containing protein (Q382E2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHSSPATSQDGFLLDFSLYRVAKYIRLLGYNAVCDSQLFRRDMVNRAVKDNLVLVTSSCALIEQAKAHNRTVQKHRSVIGGGKTVVAYDSDGESIYSEGDDDMREITFYELAHPTADNFFTLMVDAIRTLGLLYRRDRIFSRCVMCNEVLVEVVKEDVKEDVHPKVYEVYDAFTRCPACRKVFWGVDNGKVINYTAFRTLETLQRLFEAAMGPDLRPPRISHLCYFRSFPRRVHSTVFSYLSDADLRVLSVVVPKLKDLSDAVKKRSQSVR
Protein: Cytosolic 5'-nucleotidase 1A (cN1A) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.99) (5'-deoxynucleotidase) (Cytosolic 5'-nucleotidase IA) (cN-IA) (A3KFX0)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (By similarity). AMP is the major substrate but can also hydrolyze dCMP and IMP (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BXI3}.
Interaction partners:
- 5'
- Cytosolic 5'-nucleotidase 3A
- Cytosolic purine 5'-nucleotidase
- 7-methylguanosine phosphate-specific 5'-nucleotidase
- Deoxycytidine kinase
- 5'
- Deoxycytidylate deaminase
- Adenylosuccinate synthetase isozyme 1
- 5'-nucleotidase
- Cytidine deaminase
Sequence:
MEPGQPREAREPGPGAETAAVPRWEEAKTFYDNLSSKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKRLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADADKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRRAAAAKQSLGAQ
Protein: Small ribosomal subunit protein eS28 (40S ribosomal protein S28) (P62857)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6QAT1}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q6QAT1, ECO:0000269|PubMed:25957688}.
Interaction partners:
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein uL13
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein P2
- Large ribosomal subunit protein uL11
- Small ribosomal subunit protein uS3
Sequence:
MDTSRVQPIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREGDVLTLLESEREARRLR
Protein: FAD/NAD(P)-binding oxidoreductase family protein (Q9C574)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Tetratricopeptide repeat domain-containing protein PYG7, chloroplastic
- Succinate dehydrogenase subunit 3-1
- Thioredoxin Y2, chloroplastic
- F-box/kelch-repeat protein At5g42350
- Disease resistance protein
- Agamous-like MADS-box protein AGL27
- Disease resistance protein
Sequence:
MEGIESGSKQGKRVVVIGGGIAGSLAAKLLQFDAEVTLIDPKEYFEITWASLRSMVEPKFAERTVINHKSYLKQGRLVTSPAINITESDVMTEDGSVIGYDYLVIATGHNDLFPKTRQEKLSHYQSEYEKIKSSGSVLIVGGGPSGVELAAEIAVDFPEKKVTLVHKGPRLLEFVGQKAADKASDWLESKKVEVILNQSVDLSSASDGNKIYRTSGGETIHADIHFLCVGKPLSSQWLNGTVLKDSLDGKGRVMVDEYLRIRGRSNVFAVGDITNIPEMKQGYIAETHANVVVKNIKVMMSGGKKKKMSTYKPGPELAIVSLGRKDSVAQFPFVTVVGCLPGLIKSKDLFVGKTRKARGLNPKLV
Protein: 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS) (P29728)
Organism: Homo sapiens (Human)
Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19923450}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19923450}.
Interaction partners:
- 2'-5'-oligoadenylate synthase 3
- 2'-5'-oligoadenylate synthase 1
- Interferon-induced GTP-binding protein Mx1
- Signal transducer and activator of transcription 1-alpha/beta
- Antiviral innate immune response effector IFIT1
- Interferon regulatory factor 7
- Interferon alpha-inducible protein 6
- Ubiquitin-like protein ISG15
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Antiviral innate immune response receptor RIG-I
Sequence:
MGNGESQLSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEPEQFPLVQGVAIGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFEIQKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIYRELKRSLDKTNASPGEFAVCFTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPVILDPVDPTNNVSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAPRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKVPTMQTPGSCGARIHPIVNEMFSSRSHRILNNNSKRNF
Protein: Myeloid differentiation primary response protein MyD88 (B3SRQ2)
Organism: Salmo salar (Atlantic salmon)
Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Interleukin-1 receptor-associated kinase 1-like isoform X1
- NF-kappa-B essential modulator-like
- non-specific serine/threonine protein kinase
- TNF receptor-associated factor 6-like
- TNF receptor-associated factor 6-like
- Toll/interleukin-1 receptor domain-containing adapter protein-like
- E3 ubiquitin-protein ligase TRAF6
- Interferon regulatory factor 7
- Mitogen-activated protein kinase kinase kinase 7
- Mitogen-activated protein kinase kinase kinase 7
Sequence:
MSTSLDLWNIPLRALNINVRKRLGLFLNPRNTVASDWMSVAENMGFSYLEIKNYEDCLDPTRRILEDWQARCPGAKVGKLLSILDNVDRKDVVEDLRDLIEEDCRRYIERQNEPPLQVPEVDSCVPKTQERQGITLEDDPEGGIPELFDAFICYCQSDFDFVHEMXQQLEQTDHKLKLCVFDRDVLPGSCVWTITSELIEKRCKRMVVVISDEYLDSDACDFQTKFALSLCPGARSKRLIPVKYRSMKKPFPSILRFLTVCDYTRPCTQSWFWVRLARALSLP