Protein: Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger homolog) (Monocytic leukemia zinc finger protein) (Q5TKR9)
Organism: Rattus norvegicus (Rat)
Function: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2 (By similarity). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q92794}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q92794}. Nucleus, PML body {ECO:0000250|UniProtKB:Q92794}. Note=Recruited into PML body after DNA damage. {ECO:0000250|UniProtKB:Q92794}.
Interaction partners:
- Bromodomain and PHD finger containing, 1
- Inhibitor of growth protein
- Nuclear receptor coactivator 2
- Bromodomain containing 1
- histone acetyltransferase
- Chromatin modification-related protein MEAF6
- Bromodomain and PHD finger containing, 3
- Inhibitor of growth protein
- Histone acetyltransferase
- Histone lysine acetyltransferase CREBBP
Sequence:
MVKLANPLYTQWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQSVDWNKLLKRAFEGLAESGGSTLKSIERFLKSQKDVSAACGGTAASGFHQQLRLAIKRAVGHGRLLKDGPLYRLNTKAANAEGKEGCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEDLISCADCGNSGHPSCLKFSPELTVRVRALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYANPIGRPKNRLKKQSTVSKGPFSKVRTGPGRGRKRKITVSSQSASSSEEGYLERIDGLDFCRDSSAPLKFNKKTKGLIDGLTKFFTPSPDGRKARGEAVDYSELRIRKKGNRKSSTSHWPTDNQDGWESKQESEERLFGSQEIMTERDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGVCPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEDEEADDGEKEEPQGQERELETRERVGKSVSRENKDQDSSSLIESEKKPEVKELASSSRLSKQALVRDSLPANSQPPRRGRCGRKNRKTQERFGDKDSKMLVGETLSTSQEQYGECEEKSAASRERYTEVGEQPAAPQAQADGNPDIPKGRFSESADLWRGQLKKSPETLKCRLPEGNDRLPCCYTDGDRAVFRGFSESSEEEEEPESPRSNSPPVLTKPTLKRKKPILHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIEEEEEEEDENELFPRGYFHCLSSQDILRCQASSKRTASKDEEEEEEESDDADDTPVLKPVSLLRKCDVNSASLEPDTSTPMKKKKGWPKGKSRKPIHWKKRPGRKPGFKLNQDIIAVSTQECIVEPIVPIKPGRKPRTQESEELVEVKEGLVEERKEEMHTEADEEAEEEEDAASSDIRAMSPLDSSNSPDADPKEPEAEEEEEKPLDDPRQSEEEPQELEEQEQEEEDEVTAEANQNEDHDADDEDDGHLDSLKTKEPEGQPAREDGTEEPGTQESFLDASIQDSRENAKDKDETEADSEEEQPSHEASVGSETMPGSEEDHEEDSNTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTHTDEDPQMSMVEDCHASEHNSPISSIPSHPSQSVRSVSSPSMPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGSSICGNNSSQSSCSYGGLSSSSSLTQNSCVVTQQMASMGNSCSMLQQNSVQPATNCNIKSPQTCVVERPPSNQQPPPPPPPPPPPQQPQPQPQQQAAPQPPPPQPQQQPPPPPQQQPQPPPPPQQQPPLSQCSMNNSFTAAPMIMEIPESGGTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLAPTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSKSAPLPSATAHQQQLYGRSPPAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR