wanglab/gogpt-training-data huggingface dataset:
Protein: Anion exchange protein 3 (AE 3) (Solute carrier family 4 member 3) (A0A096X8J7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000269|PubMed:24668450}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGRSYNEKDFEYHRHTFHHTHHPLSTHLPPQRFRKRVLSMDRRRKRKRKKKKTSMPPSDVTPTIHEVDEEEAESEIEGQCQAATPTEPSEELPQLSLGSEEDLAADLPLSSFHMESERPASSEETLPSPASMEEKEETQQPPDGGEHKDISNSFSPSPEAASMTTRGWFRRKPVHRLAGAQRTSYDLRERICIGSMTAMETAVYQKVPTDEAEAQMLASADLDDMKSHRFEDNPGVRRHLVKKSSRCQLPRSSNGSPPLSSLKRRKRMDKKTHEVFVELNELIVDKNQEMRWKERARWIKFEEDVEEETDRWGKPHVASLSFRSLLELRRTITHGAIMLDLDQSTLPGIAHLMVETMIISDQIRAEDRANVLRALLLKHSHPNDEKEGLFHRNHSVTSLGSFRHNHNHVHDTSLPLVSQDHEEMHDSKAAEHDKEKSLHPIPAEGHAASRSLKLLAKIPKDAEATVVLVGCVEFLEKPAMAFVRLNESILLESILEVPVPIRFIFVLLGPTQTNVDYHEIGRSFSTLMSDKNFHEVAYFADDRQDLLNGINEFLDCSIVIPPSDVEGKDLLKTVASFQKQMLRKRKERELKKCASTVTGAELETKDVNIEEQEEEDQFDVDPLKRSGIPFGGLIHDIRRRYPRYISDLKDALDTQCIAAVIFIYFAALSPTITFGGLLGEKTQGMMGVSELIISTATVGVLFSLLAGQPLLIIGFSGPLLVFEEAFYKFCQAQGFEYLTGRVWIGFWLIFIVLVIVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFSKLIKVFQEHPLMMSYTSAAFKHSDQRGSSVIGEPILNQPNTALLSMVLMMGTFFTAFFLRKLRNSRFLGGKVRRVIGDFGIPISILISVLVDILIPDTYTQKLNVPSGFSVTSPDKRGWFISPFGDKQPFPVWMMGASVIPALLVFILIFMETQITTLIVSKKERRLMKGSGFHLDLLLIVTLGAICPLFGLPWLTAATVRSVTHVNALTVMSKATAPGEKPMIQEVKEQRVTGMCVAILVGLSIVMTDVLRHIPLAVLFGIFLYMGITSLTGIQLYERITLMVTPAKHHPDHVYVTKVKTWRMNMFTVIQLLCIVLLWVVKSTVASLAFPFILIMTVPLRRLILTRIFEERELAALDADEDSPNFDEDGRDEYNEIHMLV
Protein: Acyl transferase (ACT) (EC 2.3.1.-) (C14ACP-TE) (Myristoyl-ACP-specific thioesterase) (Q9S3Z2)
Organism: Aliivibrio fischeri (Vibrio fischeri)
Function: Acyl transferase is part of the fatty acid reductase system required for aldehyde biosynthesis; it produces fatty acids for the luminescent reaction.
Interaction partners:
Sequence:
MKDESAFFTIDHIIKLDNGQSIRVWETLPKKNVPEKKHTILIASGFARRMDHFAGLAEYLSTNGFHVIRYDSLHHVGLSSGCINEFTMSIGKNSLLTVVDWLTDHGVERIGLIAASLSARIAYEVVNKIKLSFLITAVGVVNLRDTLEKALEYDYLQLPISELPEDLDFEGHNLGSEVFVTDCFKHNWDTLDSTLNSVKGLAIPFIAFTANDDSWVKQSEVIELIDSIESSNCKLYSLIGSSHDLGENLVVLRNFYQSVTKAALALDDGLLDLEIDIIEPRFEDVTSITVKERRLKNEIENELLELA
Protein: AT4g02010/T10M13_2 (Protein kinase superfamily protein) (Q8L7V7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSIFSLASSSDSQRDDLIMALKAVVIVYCVVSLVSVQLADAQHEGLPVSPTLSPSTSPVITDLPLPAEFPRFHRKYFAPQQAEAPQHSPPYSRLVASDHPPTSSHFSKPSMKRNAQSPGAGLADIAPAQSSNGVLPDALTQPPLSPSISNCCKSDMVLKRRSIGCHCVYPIKLDILLLNVSETPSWNMFLNEFATQLGLLPHQIELINFYVLSLSRMNISMDITPHSGISFSASQASAINSSLISHKIQFSPTLVGDYKLLNLTWFEAPAPSQAPLVASSPHKAPSQGSSATTSVRSPGKKRHPNLILIFSIAAGVLILAIITVLVICSRALREEKAPDPHKEAVKPRNLDAGSFGGSLPHPASTRFLSYEELKEATSNFESASILGEGGFGKVYRGILADGTAVAIKKLTSGGPQGDKEFQVEIDMLSRLHHRNLVKLVGYYSSRDSSQHLLCYELVPNGSLEAWLHGPLGLNCPLDWDTRMKIALDAARGLAYLHEDSQPSVIHRDFKASNILLENNFNAKVADFGLAKQAPEGRGNHLSTRVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLTGRKPVDMSQPSGQENLVTWTRPVLRDKDRLEELVDSRLEGKYPKEDFIRVCTIAAACVAPEASQRPTMGEVVQSLKMVQRVVEYQDPVLNTSNKARPNRRQSSATFESEVTSSMFSSGPYSGLSAFDHENITRTTVFSEDLHEGR
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (E7F2F9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSENLNDKMVKFLSPPSKNTNGSSSDTLVGEHLGVDVRRRHHTMDRELLKAEHRFFRRSVINDSNATALELPSKNAILTHSTDSHAPVCEPPALETKAASVITQSAPEKKVADVVEMVIESTPVLITNAALHLSAEAPSLVSEVKSGDGIDGKREAEKEEDEDSKEKAARAEAELRDAKKEEEDNEEIETNAVGTSPDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLSKSERQRFKEEAGMLKGLQHPNIVRFYDSWESSLKGRKCIVLVTELMTSGTLKTYLKRFKEMKIKVLRSWCRQILKGLHFLHTRSPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPGSFDKVAIPEVKEIIEGCIRQNKDERYCIKDLLSHAFFQEETGVRVELAEEDDGELVAIKLLLRIEDVKKLKGKYKENEAIEFSFDLDKDVPDDVAQEMVESGYICEGDHKTIAKAIKDRVSLISRKREQRKLVREEQEKRKMEQENDAAQQTNPTVKSPGSALASVIMESEEAETDQHQQPGASASAVGFVDPQSSVTILEAHPVQPNTSFSTTQPDPQPQHTIIRPQSMSQHPVQAPLQQPSSTLTLGPVPQTSPPQVIGQTASLPSTVQSIVPLQYRQPPQDGITLPQSLPSAQVLQIWACQLSPPVFSPPPNAEQLYFLYQACQAPLSVSQSQPVEQTQPQTSLVPASTESGHSDPASGLSDGNEGRHEGRSMKRPQRRSVRSRSRHEKTAKVKLNVLNISNIGDRVAECQLETHNRKMVTFKFDLDGDNPVEIAEIMVKSDFILESERESFIEQVQLVIQNADQKGKAPQNSQTQVISNSSQQVPEILTSSVPGMPPSLAAQVVHSAGRRFIVSPVPEARLREPLFGTPSANTSFEDTAPAPDPTSASSAPQDQANFASDSNQISVVPPTPGDLAPESSIPPTSQSPYQNPVPSSTATLTVTTTQVSTPTPTTTPQPITGRTSPSPAPTEPPAARRMSLPSPSQTPQIAPGESNGLDQAQASNQQVTQPSATGDSESDVQGKPPGIEDIHALDQKLRSLFKDSSQNSCSQPDGSGETSTTSPPNTISTNTPGFVSGVTPSSLSLNSSGNFAPGAFASIGTPTSYTQTPSTDQSPPRPQIAVGVTQPDGHNSTEEKEPQLEKAFQLGRFQVSVASDQDPPTALDPGVVVSSSSATPSSTSSSSSSSSSPSSLSSPENTIHKSQTPPPRVSPEPVPPTTTVGRFQVTCSTDIKLGRFSVTPAERKSSSVEGPDTAKEPKLTPSSVSITNHYLSSDNDSEPEDEGLRREMNRLKERHKVEIMALQNKQKKEIEELFTRLGKTPSVVVPPTVAMTPGRRRPAKGKGNRPRSGSATQAASFQQGNKQAVQSGSLSQSASEKTSPSETAPSSNNDVQDNTSPVRKENGQSHDQDQTPTTNLPRKGTFTDDLHQLVDNWARDAMNMMPQVKKGSKKNVHEMPRKYSAPGQLCSTGGHIPATINPTAGRKGSIGVANQQFGYTCPNYNMPQWNQVGTISSTAPPAGLQQGFLIPSGAHQTGNNCGSSNLRTTQAS
Protein: Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit K) (Proteasome subunit alpha-7) (alpha-7) (P18422)
Organism: Rattus norvegicus (Rat)
Function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P25788}. Nucleus {ECO:0000250|UniProtKB:P25788}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P25788}.
Interaction partners:
- Proteasome subunit beta type-7
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-7
- Proteasome subunit beta type-6
- Proteasome subunit beta type-2
- Proteasome subunit beta type-3
- Proteasome subunit alpha type-5
- Proteasome subunit beta type-1
- Proteasome subunit beta type-9
- 26S proteasome regulatory subunit 10B
Sequence:
MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDVREEAEKYAKESLKEEDESDDDNM
Protein: Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) (P48147)
Organism: Homo sapiens (Human)
Function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
Subcellular location: Cytoplasm.
Interaction partners:
- Dipeptidyl peptidase 8
- Pyroglutamyl-peptidase 1
- Dipeptidyl peptidase 9
- Dipeptidyl peptidase 4
- Acylamino-acid-releasing enzyme
- Lysosomal Pro-X carboxypeptidase
- Pro-thyrotropin-releasing hormone
- Thimet oligopeptidase
- Palmitoyltransferase ZDHHC3
- Thymus-specific serine protease
Sequence:
MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
Protein: AbpA (A9P3U3)
Organism: Emericella nidulans (Aspergillus nidulans)
Interaction partners:
Sequence:
MASLNLSANGPSISKSYQSVVDYAITDSAKSSSTFAKWVLFSVSTPLVSAFQQDASNKESVLKVQDTGEGELADLIDEFSEGKIQFAFVKVIDTNTGLPKSVLIAWCGEGVPERTKGYFTSHLSTVSKFLHGYHVQITARSEADLTVEGIIQKVGDASGAKYTQGLEKPNASVPKPPVSSKPVFTPLRTGGINVNAAAAAPLPLRAKKNDDDGWGPDAPPVTRTNLEKVEPAYKPTRVNIQELKSEKQNEPTVNPSLTTGHQPDGVIKGGYQPIGKVDIAAIRRQAREAGNLTDDRPEPVKGAYQPVGKVDIAAIRARAQKPDETDTSSKGSSARPDGSSGPTTDLDSTESSRLTSLPKPKVTNKFASSTSFTGTKPPLPGGNALSATPVPPIGSASRTFADQGGKTPAQLWAEKKAKERSQEPAAAEESTKPAVANNVQSQLSGVREWKSSYTGRTWAPVQTTHTGKSVENNRTEVAGSFATGMPTPEAITAQQSEGIAQDQLTQGPPKEAPSSPEAGEPVSSLSIPAEATAGVPREPQAPQPPVLQTQIPESSTLERSEGESSPIRVAMPVAKDAIDDHETRNAATMAEPLERPEEVSLVDSDENRLTQNADFEAVPIGKAGVGELRALVHYDYEKAEDNEVDLREGEFVTEIEMVDKDWWLGSNAQGERGLFPSNYVELLEDGRQSRAESDTRPADAHESEALADPTPTSGSHVKPTAKALYDYEAAEDNELSFPEGAEIINIEFPDDDWWLGEFRGKTGLFPANYVQLDD
Protein: Hematopoietically expressed homeobox (Q9WV22)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MQFPHPGPAAAPAVGVPLYAPTPLLQPAHPTPFYIDDILGRGPAAPTPTPTLPSPNSSFTSLVSSYRTPVYEPTPVHPAFSHHPAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWNPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKDELDSLDTSCDQGQDLPSEQNKGASLDSSQCSPSPASPEDPESEISEDSDQEVDIEGDKGYFNAG
Protein: Inter-alpha-trypsin inhibitor heavy chain-like protein (Q8L798)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ribosome production factor 2 homolog
- Large ribosomal subunit protein uL18y
Sequence:
MAEDFARAVDDGLKLAKRIYFGKDRAVAAPRPPAPMDRSSTTQPYLPTAPMVYAVIPDPGIVDNPDLPSYQPHVHGRCDPPALIPLQMNSIELDVDCYLDTALVTVTGSWRVHCVMGSKRCDCRIAIPMGEQGSILGVEVEIPRKSYTTQLITAEDGNEFEKTALPETGGFLKPNIFTLTIPQVDGGTNLSIKMTWSQKLTYNQGQFFLDIPFNFPEYVTPAVKKISKREKIYLSVNAGTGTEVLCKGCSHQLKEKLRSAGKLRFAYEADVLKWSNTDFSFSYTASSSNIVGGLFLQSAPVHDVDQRDIFSFYLFPGKQQKTKAFKREVVFVVDISKSMTGKPLEDVKNAISTALSKLDPGDSFNIITFSNDTALFSTSMESVTSDAVERGIEWMNKNFVVADGTNMLPPLEKAVEMLSNTRGSIPMIFFVTDGSVEDERHICDVMKKHLASAGSVFPRIHTFGLGVFCNHYFLQMLANISCGQHESVYNTDHIEERMDKLFTKALSTILVNIAIEPLQSLDEVEVYPSNIPDLTSASPLMIYGRYRGKFPENVIAKGLLGDLSSFSTDLTVQSAKDMPLDKVFAKNVIDLLTAEAWFSEDKQLKEKIAKLSIQTGVLSEYTRMIQLENTEELKPSETGGKKKTTSNGEKQKMISRTIPLQSLGIGFGDKTATRENVPPGFGEQKAPDAAEKFVKAASSCCVSLCNKCCCMCCVQCCSKLNDQCVLVFTQLFTAIACIACFECCSTVCCSGDDG
Protein: Small ribosomal subunit protein mS26 (28S ribosomal protein S26, mitochondrial) (H6UQ71)
Organism: Gallus gallus (Chicken)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAPGGCPLLALLLLAGTAQGQHWSHGWYPGGKRDLSAPQAIPAWSPWLVPSRGRKSRYDPPAKAKASRLKVPPPVDPAELYVVTERYRQHRLVLSALRSIFRSEVVQRKSEAQRDAEDSAALSEEHRLLMAWNDAENARQRARR
Protein: Cytochrome P450 1A (EC 1.14.14.1) (Q9PRH3)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU368045}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368045}. Microsome membrane {ECO:0000256|RuleBase:RU368045}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368045}.
Interaction partners:
Sequence:
MVLMILPIIGSVSASEGLVAMVTLCLVYMIMKYMHTEIPEGLKRLPGPKPLPIIGNVLEVHNNPHLSLTAMSERYGSVFQIQIGMRPVVVLSGSETVRQALIKQGEDFAGRPDLYSFKFINDGKSLAFSTDKAGVWRARRKLAMSALRSFATLEGSTPEYSCALEEHVCKEGEYLVKQLTSVMDVSGSFDPFRHIVVSVANVICGMCFGRRYSHDDQELLGLVNMSDEFGQVVGSGNPADFIPILRYLPNRTMKRFMDINDRFNTFVQKIVSEHYDSYDKDNIRDITDSLIDHCEDRKLDENANVQVSDEKIVGIVNDLFGAGFDTISTALSWAVVYLVAYPEIQERLHQELKEKVGMIRTPRLSDKINLPLLEAFILEIFRHSSFLPFTIPHCTVKDTSLNGYFIPKDTCVFINQWQVNHDPELWKEPSSFNPDRFLSADGTELNKLEGEKVLVFGMGKRRCIGEAIGRNEVYLFLAILLQRLCFQEKPGHPLDMTPEYGLTMKHKRCQLKASLRPWGQEE
Protein: Septin (Q4WWT7)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- Septin AspA, putative
- Septin-type G domain-containing protein
- Septin AspB
- Septin
Sequence:
MATVSRPRTPGQTQPSSNTLSPITENGNGHFKDQRRASSLGFLRRAKSTEPLSERKSSGSRSKKRTQAQEEELRRQRESMPQFPPRLPDLAPTPVIDAFGGDGQHDSVPTPSKETIASHHNLAIRSNMTTSAEVVDPYARTESMTHRGRYSYASSAVSTVNNPRRMRRRKDPTPYNVLVIGARNSGKTSFLNFLRKSLTMPPHKHPIRSPEEVEAYERHSPANEGFTSHYLETEIDGERVGLTLWDSQGLEKNIVDIQLRGVTGFLESKFEETLREETKVIRSPGFRDTHIHCTFLLLDPVRLDENIAAAERAAQGTSKATDTPVIGVLDEFLDIQVLRTVLGKTTVVPVISKADTITTAHMSYLKKAVWQSLKKANIDPLEILTLEDQDEYTSSESADEDEEGNDPDDNADEEHKAESDLADKGKAEVSPPGSPSQRSEQTTQSSGSQAASQYLPFSILSPDPHSLEAGDEPVGRKFPWGFANPYDPEHCDFVKLKDSVFTDWRTELREASRVVWYERWRTSRLNRNGISASPMQKTYSGRMGPSHDGRRTR
Protein: Protein BRASSINOSTEROID INSENSITIVE 1 (AtBRI1) (EC 2.7.10.1) (EC 2.7.11.1) (Brassinosteroid LRR receptor kinase) (O22476)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor with a dual specificity kinase activity acting on both serine/threonine- and tyrosine-containing substrates. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering. Binds brassinolide (BL), and less effectively castasterone (CS), but not 2,3,22,23-O-tetramethylbrassinolide or ecdysone. May be involved in a feedback regulation of brassinosteroid biosynthesis. Phosphorylates BRI1-associated receptor kinase 1 (BAK1), Transthyretin-Like protein (TTL) and SERK1 on 'Ser-299' and 'Thr-462' in vitro. May have a guanylyl cyclase activity. Phosphorylates BSK1, BSK2 and BSK3 in vitro. Phosphorylates BSK1, BSK3, BSK5, BSK6, BSK8 and BSK11 in vitro.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26071421}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane; Single-pass type I membrane protein.
Interaction partners:
- BRI1 kinase inhibitor 1
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Somatic embryogenesis receptor kinase 1
- Protein BRASSINAZOLE-RESISTANT 2
- Serine/threonine-protein kinase BSK1
- Serine/threonine-protein kinase BSK3
- Serine/threonine-protein kinase BSK8
- Serine/threonine-protein kinase BSK11
- Protein BRASSINAZOLE-RESISTANT 1
- Serine/threonine-protein kinase BSK7
Sequence:
MKTFSSFFLSVTTLFFFSFFSLSFQASPSQSLYREIHQLISFKDVLPDKNLLPDWSSNKNPCTFDGVTCRDDKVTSIDLSSKPLNVGFSAVSSSLLSLTGLESLFLSNSHINGSVSGFKCSASLTSLDLSRNSLSGPVTTLTSLGSCSGLKFLNVSSNTLDFPGKVSGGLKLNSLEVLDLSANSISGANVVGWVLSDGCGELKHLAISGNKISGDVDVSRCVNLEFLDVSSNNFSTGIPFLGDCSALQHLDISGNKLSGDFSRAISTCTELKLLNISSNQFVGPIPPLPLKSLQYLSLAENKFTGEIPDFLSGACDTLTGLDLSGNHFYGAVPPFFGSCSLLESLALSSNNFSGELPMDTLLKMRGLKVLDLSFNEFSGELPESLTNLSASLLTLDLSSNNFSGPILPNLCQNPKNTLQELYLQNNGFTGKIPPTLSNCSELVSLHLSFNYLSGTIPSSLGSLSKLRDLKLWLNMLEGEIPQELMYVKTLETLILDFNDLTGEIPSGLSNCTNLNWISLSNNRLTGEIPKWIGRLENLAILKLSNNSFSGNIPAELGDCRSLIWLDLNTNLFNGTIPAAMFKQSGKIAANFIAGKRYVYIKNDGMKKECHGAGNLLEFQGIRSEQLNRLSTRNPCNITSRVYGGHTSPTFDNNGSMMFLDMSYNMLSGYIPKEIGSMPYLFILNLGHNDISGSIPDEVGDLRGLNILDLSSNKLDGRIPQAMSALTMLTEIDLSNNNLSGPIPEMGQFETFPPAKFLNNPGLCGYPLPRCDPSNADGYAHHQRSHGRRPASLAGSVAMGLLFSFVCIFGLILVGREMRKRRRKKEAELEMYAEGHGNSGDRTANNTNWKLTGVKEALSINLAAFEKPLRKLTFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQAGSGIDSQSTIRSIEDGGFSTIEMVDMSIKEVPEGKL
Protein: Protein salivary glands marred (Tumor necrosis factor alpha-induced protein 8-like protein) (TNF alpha-induced protein 8-like protein) (Q7KVH9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Important for modulating JNK signaling, cytoskeletal remodeling and autophagy in larval salivary glands. During salivary gland development, involved in the positive regulation of the JNK signaling pathway, acting downstream of the TNF ligand egr and upstream of bsk.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25836674}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25836674}. Note=Localizes to actin containing cellular projections and microtubules. {ECO:0000269|PubMed:25836674}.
Interaction partners:
- F-box and WD repeat domain containing 5
- 205 kDa microtubule-associated protein
Sequence:
MADNVFKSHDIGLRAQKKILSRMATKNIAKTFIDGTTASLLDNLYRLCKMHTGNKAKAEKLIKNIIKIVIKIGVLHRNNQFSDEELQKAELFKRKFQNTQLSIISFYEVDFTFDLPYLQKSIAESQVALKSIVQPHLTEKSLGRIDEVFDFFGEEALLETAFRPDSPYREVMGKIVADINAAMETGDI
Protein: Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Synectin-binding RhoA exchange factor) (SYX) (Q66T02)
Organism: Mus musculus (Mouse)
Function: Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16467373}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16467373}. Cell membrane {ECO:0000269|PubMed:16467373}. Cell junction {ECO:0000269|PubMed:21543326}. Cell projection, lamellipodium {ECO:0000269|PubMed:21543326}. Note=Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane (PubMed:16467373). Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (PubMed:21543326). {ECO:0000269|PubMed:16467373, ECO:0000269|PubMed:21543326}.
Interaction partners:
- Rho guanine nucleotide exchange factor 11
- Rho guanine nucleotide exchange factor 12
- Rho-related GTP-binding protein RhoE
- Transforming protein RhoA
Sequence:
MGTGPGVSGRRAAARPSSELPSPDSQLLWVGGHAHSSDSQVCHHADCQQLHHRGPLNLCETCDSKFHSTLHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAADLEEEEEGCTDGKGDRKSAGLKISKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAKPGDEGKVEQGVKDSKSLSLPALRPSGAGPPVSERVDPQSRRESSLDILAPGRRRKNMSEFLGEAGIPGHEPPAPSSCSLPVGSSGGTSSGINESWKNRAASRFSGFFSSSPSTSAFSREVDKMEQLESKLHAYSLFGLPRMPRRLRFDHDSWEEEEEDDEEDEESSGLRLEDSWRELTDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTKVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASSQALCRSWVDTIYNAQNQLQQLRAQLSAQEHPGSQHLQSLEEEEDEQEEEGEESGTSAASSPTILRKSSNSLDSEHCTSDGSTETLAMVVVEPGATLSSPEFEGGPVSSQSDESSLSNTASSVTPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPHPVVEPAPVPQTPSPQPSPRLRRRTPVQLLPRPPRLLKSKSEASLLQLLSGTPAARGVPPAPSRSLSELCLISVAPGVRTQRPLQEGGPGWNGPGMCDPCHGPQLSESENRPSHMTGGPADSARRRCREMPSGTMSRVQSEPPSGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
Protein: CD2 antigen cytoplasmic tail-binding protein 2 homolog (Protein hole-in-one) (Q9VKV5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for embryonic epithelial tissue repair, but not for the assembly of the actomyosin cable at the wound edge. Probably acts downstream of rl in the regulation of Ddc and msn transcription to promote wound healing.
Subcellular location: Nucleus {ECO:0000269|PubMed:22140578}.
Interaction partners:
- Pre-mRNA-processing-splicing factor 8
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Probable ATP-dependent RNA helicase DDX23
- 116 kDa U5 small nuclear ribonucleoprotein component
- Protein AAR2 homolog
- Small nuclear ribonucleoprotein-associated protein B
- Thioredoxin-like protein
- Obelus
- Pre-mRNA-processing factor 6
- U5 small nuclear ribonucleoprotein TSSC4
Sequence:
MASKRKHQASQKVKEESFKKHTLDSDEEDSDDYEREYLNDSDIEGGEEGVAKVEDDVKVTPFNMKEELEEGHFDKDGHYHWNKETEAKDNWLDNIDWVKIGTQKNAFDPAKDEENSSDEEKNEPVGKAFNLSMNLMKMVEFMKPGETVKMTLQRLGKQRPVLTTLQRIKQKKAGIVDPKTQEISQLTELANEILSKTGNMDIYQDTYESIKAKIADLPGTSKPKVADDIDMYADDFETKELERSKTSSSDSSKPTTTTSEVTWEFKWSQDETDIQGPFSTEKMLKWSQENYFKNGVYVRKCGENTNFYTSNRIDFDLYL
Protein: Negative elongation factor E (Q6DHD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAIFPSSLTEDEEALQKKYAKLKKKKKALMALKKQSSTNQTSQTGLKRTLSDQPVVDTATATEQAKMLVKSGAISAIKSENKNSGFKRSRMLEGKLKDPEKGPAPAFLPFQRSVSTDEEPPDSAKRIHRKSLYESFVPGDRSRDEEAGMPSRDSERDREREMDWERDRERDRDRERDRERGRERERDRERERDRSRDGERDRERDRDRDRERDRERDGPYRRSDSYPERRGVRKGNTVYVYGTGLVEDSLRTAFAQHGNIIDLSMDSPRNCAFVTFEKIESADQAVAELNGTTVGDVNIKVSIARKQPMLDAATGKSVWASLAVQNSAKGSYRDKRSQVVYSEDFL
Protein: Uncharacterized protein, isoform A (EC 3.4.21.-) (Q9VR15)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRVYLALPLLLLGIGLSLAQYQYQAPHQTLAQQFADVVDVVDPAEQSIKAVRPPKSRNQCTAKQNCFCGTPNVNRIVGGQQVRSNKYPWTAQLVKGRHYPRLFCGGSLINDRYVLTAAHCVHGNRDQITIRLLQIDRSSRDPGIVRKVVQTTVHPNYDPNRIVNDVALLKLESPVPLTGNMRPVCLPEANHNFDGKTAVVAGWGLIKEGGVTSNYLQEVNVPVITNAQCRQTRYKDKIAEVMLCAGLVQQGGKDACQGDSGGPLIVNEGRYKLAGVVSFGYGCAQKNAPGVYARVSKFLDWIRKNTADGCYCQS
Protein: TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) (Q8BYJ6)
Organism: Mus musculus (Mouse)
Function: May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11994271}. Note=Cytoplasmic perinuclear. {ECO:0000250}.
Interaction partners:
- RAC-beta serine/threonine-protein kinase
- RAC-alpha serine/threonine-protein kinase
- RAC-gamma serine/threonine-protein kinase
- Leucyl-cystinyl aminopeptidase
- Solute carrier family 2, facilitated glucose transporter member 4
- Ras-related protein Rab-8A
- Ras-related protein Rab-10
- 14-3-3 protein zeta/delta
- Insulin-1
- Insulin-2
Sequence:
MESPSCIQDEPFPHPLEPEPSAPAQPGATKPGDKRFRLWYVGGSCLDRRTTLPMLPWLMAEIRRRSQKPDAGGCGAPAAREVILVLSAPFLRCVPAPGAGVGGGAGSGAVQPNTGVFIFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPNQVPDVISSIRQLSKAAMKEDSKPSKDNEDAFYNSQKFEVLYCGRVIVTHKKAPSSLIDDCKDKFSLHEQQRLKLQGERGGDPGDEMGVLEVESPVSPDDSLPEKADGTVNSPRALPSLASLPALASQPALASSRVCFPERILEDCGFDEQQEFRSRCSSVTGVMQKKVHENNQKTQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCANESLVDEVMLTLKQAFSTAAALQSAKTQIKLCETCPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPISDQEENELVILHLRQLCEAKQRTHVHIGEGPAIISNSTIPENVTSGGRFKLDVLKNKAKRSLTSSLENIFSRGANRMRGRLGSMDSFERANSLASEKDFSPGDSPPGTPPASPLSSAWHAFPEEDSDSPQFRRRAHTFSHPPSSSRRKLNLQDGKAHGLRSPLLRQSSSEQCSIVPSARRMYKESNSSCSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLNAGGTPVTPRRVSWRQRIFLRVASPVNKSPSAMQQQKDGLDRTELLPLSPLSPTMEEEPLIIFLSGDEDTEKVEEKKKSKELKSLWKKAIHQQILLLRMEKENQKLEEARRDELQSRKVKLDYEEVGTCQKEILIAWDKKLLNCRTKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKHQPPDTSYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRELYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSSQEALIMECENFENIVEFLKSTLPDMNTTEMEKIITQVFEMDISKQLHAYEVEYHVLQDELLESSYACEDNESLEKLERANNQLKRQNMDLLEKLQVAHAKIQALESNLETLLTRETKMKALIRTLEQDKMAYQKTVEQIRKLLPADALANCELLLKDLTHPTNDKAKAGNKP