wanglab/gogpt-training-data huggingface dataset:
Protein: 4-coumarate--CoA ligase 1 (4CL 1) (EC 6.2.1.12) ((E)-ferulate--CoA ligase) (EC 6.2.1.34) (4-coumarate--CoA ligase isoform 1) (At4CL1) (4-coumaroyl-CoA synthase 1) (Q42524)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Produces CoA thioesters of a variety of hydroxy- and methoxy-substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioesters (By similarity).
Interaction partners:
- Trans-cinnamate 4-monooxygenase
- Cinnamoyl-CoA reductase 1
- Cinnamoyl-CoA reductase 2
- Cytochrome P450 84A1
- Phenylalanine ammonia-lyase 1
- Flavone 3'-O-methyltransferase 1
- Phenylalanine ammonia-lyase 2
- Phenylalanine ammonia-lyase 4
- Caffeoyl-CoA O-methyltransferase 1
- F5F19.5 protein
Sequence:
MAPQEQAVSQVMEKQSNNNNSDVIFRSKLPDIYIPNHLSLHDYIFQNISEFATKPCLINGPTGHVYTYSDVHVISRQIAANFHKLGVNQNDVVMLLLPNCPEFVLSFLAASFRGATATAANPFFTPAEIAKQAKASNTKLIITEARYVDKIKPLQNDDGVVIVCIDDNESVPIPEGCLRFTELTQSTTEASEVIDSVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSDDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEINLLLELIQRCKVTVAPMVPPIVLAIAKSSETEKYDLSSIRVVKSGAAPLGKELEDAVNAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTGDSLSRNQPGEICIRGHQIMKGYLNNPAATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIGHPDITDVAVVAMKEEAAGEVPVAFVVKSKDSELSEDDVKQFVSKQVVFYKRINKVFFTESIPKAPSGKILRKDLRAKLANGL
Protein: Serine/threonine-protein phosphatase PP2A-like PPG1 (EC 3.1.3.16) (P32838)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in glycogen accumulation.
Interaction partners:
- Type 2A phosphatase-associated protein 42
- Protein phosphatase PP2A regulatory subunit A
- Serine/threonine-protein phosphatase 4 regulatory subunit 2
- Factor arrest protein 8
- Factor arrest protein 11
- Protein phosphatase PP2A regulatory subunit B
- Serine/threonine-protein phosphatase 4 regulatory subunit 3
- Factor arrest protein 10
- Vacuolar protein sorting-associated protein 64
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Sequence:
MELDECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTECLNKYGGNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNNPTLDHPDNSGQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFEEAPENKLLKENSMNDNALEDSISNPVANRKLIADYFEDDSASADGSTDPEMYIFSDVYQARSASNRHVDYFL
Protein: Putative colanic acid biosynthesis acetyltransferase WcaB (EC 2.3.1.-) (P0ACC9)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Putative colanic acid biosynthesis glycosyl transferase WcaC
- Putative colanic acid biosynthesis glycosyl transferase WcaA
- Putative colanic acid biosynthesis acetyltransferase WcaF
- Putative colanic acid biosynthesis glycosyl transferase WcaE
- Putative colanic acid biosynthesis glycosyl transferase WcaI
- Putative colanic acid polymerase
- Tyrosine-protein kinase wzc
- UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
- GDP-mannose mannosyl hydrolase
- Putative polysaccharide export protein Wza
Sequence:
MLEDLRANSWSLRPCCMVLAYRVAHFCSVWRKKNVLNNLWAAPLLVLYRIITECFFGYEIQAAATIGRRFTIHHGYAVVINKNVVAGDDFTIRHGVTIGNRGADNMACPHIGNGVELGANVIILGDITLGNNVTVGAGSVVLDSVPDNALVVGEKARVKVIK
Protein: Membrane-associated protein UidC (Q47706)
Organism: Escherichia coli (strain K12)
Function: Enhances the activity of the UidB (GusB) glucuronide transporter, on its own however it has no transport activity. Glucuronide transport does not occur in strain K12 due to a variant at position 100 of the UidB (GusB, AC P0CE44, AC P0CE45) protein.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:15774881}.
Interaction partners:
- Glucuronide carrier protein homolog
- Beta-glucuronidase
- Protein YdgA
Sequence:
MRKIVAMAVICLTAASGLTSAYAAQLADDEAGLRIRLKNELRRADKPSAGAGRDIYAWVQGGLLDFNSGYYSNIIGVEGGAYYVYKLGARADMSTRWYLDGDKSFGFALGAVKIKPSENSLLKLGRFGTDYSYGSLPYRIPLMAGSSQRTLPTVSEGALGYWALTPNIDLWGMWRSRVFLWTDSTTGIRDEGVYNSQTGKYDKHRARSFLAASWHDDTSRYSLGASVQKDVSNQIQSILEKSIPLDPNYTLKGELLGFYAQLEGLSRNTSQPNETALVSGQLTWNAPWGSVFGSGGYLRHAMNGAVVDTDIGYPFSLSLDRNREGMQSWQLGVNYRLTPQFTLTFAPIVTRGYESSKRDVRIEGTGILGGMNYRVSEGPLQGMNFFLAADKGREKRDGSTLGDRLNYWDVKMSIQYDFMLK
Protein: Helix-loop-helix protein 1 (HEN-1) (Class A basic helix-loop-helix protein 35) (bHLHa35) (Nescient helix loop helix 1) (NSCL-1) (Q02575)
Organism: Homo sapiens (Human)
Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- LIM/homeobox protein Lhx9
Sequence:
MMLNSDTMELDLPPTHSETESGFSDCGGGAGPDGAGPGGPGGGQARGPEPGEPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV
Protein: Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9) (P08134)
Organism: Homo sapiens (Human)
Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cleavage furrow {ECO:0000269|PubMed:16236794}. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
Interaction partners:
- Rho GDP-dissociation inhibitor 1
- Formin-like protein 2
- Protein diaphanous homolog 1
- Rho-associated protein kinase 1
- Rhotekin
- Transforming protein RhoA
- Rho guanine nucleotide exchange factor 11
- Rho guanine nucleotide exchange factor 12
- Formin-like protein 3
- Rho guanine nucleotide exchange factor 3
Sequence:
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL
Protein: Isoaspartyl dipeptidase (EC 3.4.19.-) (P39377)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. The best substrate for the enzyme reported thus far is iso-Asp-Leu.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7876157}.
Interaction partners:
- Inner membrane protein YjiG
- Uncharacterized protein YjiH
Sequence:
MIDYTAAGFTLLQGAHLYAPEDRGICDVLVANGKIIAVASNIPSDIVPNCTVVDLSGQILCPGFIDQHVHLIGGGGEAGPTTRTPEVALSRLTEAGVTSVVGLLGTDSISRHPESLLAKTRALNEEGISAWMLTGAYHVPSRTITGSVEKDVAIIDRVIGVKCAISDHRSAAPDVYHLANMAAESRVGGLLGGKPGVTVFHMGDSKKALQPIYDLLENCDVPISKLLPTHVNRNVPLFEQALEFARKGGTIDITSSIDEPVAPAEGIARAVQAGIPLARVTLSSDGNGSQPFFDDEGNLTHIGVAGFETLLETVQVLVKDYDFSISDALRPLTSSVAGFLNLTGKGEILPGNDADLLVMTPELRIEQVYARGKLMVKDGKACVKGTFETA
Protein: Uncharacterized protein (Q583W4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- ATP-dependent DNA helicase PIF1
Sequence:
MNRQQRQPQGGLTSRSVNLPPRSANLANKTSTVTKPSASPPASATSRSNRKSDPASNEKVSDSKLEYENALAQLQLIQQKLRQQALTACHLEREALEFYYSHVICFEGYSGEPMPQQQSSSHHYYFNSTIARARQTDRERRATEEQQLQRERCRVEQLEEELRSSVVMKRLEEERCAVRSAEAEKEALERQLAQKHAERNSREEELQKQREKLQQMRREFLEREAGIRQLEIGKRKQMEDMETIRLQLKTQRGELDSAQTELQRREKVVEDLQQTIERLSRKK
Protein: Large ribosomal subunit protein uL2 (50S ribosomal protein L2) (Q9AMK8)
Organism: Streptomyces collinus
Function: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
Interaction partners:
Sequence:
MAIRKYKPTTPGRRGASVADFVEVTRSTPEKSLVRPLHSKGGRNNAGRITVRHQGGGHKRAYRIVDFRRHDKDGVPAKVAHIEYDPNRSARIALLHYADGEKRYILAPRNLQQGDRVENGPGADIKPGNNLALRNIPVGTTIHAIELRPGGGAKFARSAGASVQLLAKEGAYAHLRMPSGEIRLVNVRCRATIGEVGNAEQSNINWGKAGRKRWLGVRPTVRGVVMNPVDHPHGGGEGRTSGGRHPVSPWGKPTGRTRSNKKASNKYIVRRRTKNKKR
Protein: Protein YffB (P24178)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Succinyl-diaminopimelate desuccinylase
- UPF0235 protein YggU
Sequence:
MVTLYGIKNCDTIKKARRWLEANNIDYRFHDYRVDGLDSELLNDFINELGWEALLNTRGTTWRKLDETTRNKITDAASAAALMTEMPAIIKRPLLCVPGKPMLLGFSDSSYQQFFHEV
Protein: Benzaldehyde dehydrogenase, mitochondrial (EC 1.2.1.28) (2-phenylacetaldehyde dehydrogenase) (EC 1.2.1.39) (Acetaldehyde dehydrogenase) (EC 1.2.1.3) (C7A2A0)
Organism: Antirrhinum majus (Garden snapdragon)
Function: Component of the floral volatile benzenoid/phenylpropanoid (FVBP) biosynthetic pathway. Catalyzes the oxidation of benzaldehyde to benzoic acid (BA). Capable of oxidizing a broad spectrum of aliphatic aldehydes; increased carbon chain length results in a decrease in its efficiency.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19292760}.
Interaction partners:
Sequence:
MAAHRFSSLLSRSVPLLSRGGKQSYLGRGVYRYGTAAAAALEEPIKPPVSVQYDKLLINGQFVDAASGKTFPTLDPRSGEVIAHVAEGDAEDINRAVAAARKAFDEGPWPKMPAYERQKIMLRFADLVEKHNDEVAALEAWDSGKPYEQCAQVEIPMFVRLFRYYAGWADKIHGLTIPADGPHHVQTLHEPIGVAGQIIPWNFPLVMFGWKVGPALACGNSVVLKTAEQTPLSALLVSKLFHEAGLPEGVLNIVSGFGPTAGAALCRHMDVDKLAFTGSTETGKIVLELSAKSNLKPVTLELGGKSPFIVCEDADVDKAVELAHFALFFNQGQCCCAGSRTFVHEKVYDEFVEKAKARALKRTVGDPFKAGMEQGPQVDADQFEKILKYIRSGAESGATLETGGDRLGTKGYYIQPTVFSDVKDDMLIAKDEIFGPVQTILKFKELDEVIRRANNSSYGLAAGVFTQNLDTANTMMRALRAGTVWINCFDTFDAAIPFGGYKMSGIGREKGEYSLKNYLQVKAVVTALKNPAWL
Protein: Hydroxyproline-rich glycoprotein family protein (F4I764)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Histone-binding protein MSI1
- Probable methyltransferase PMT4
- Integral membrane hemolysin-III-like protein
- At5g55620
- At2g40630/T2P4.2
- Transcription factor-like protein DPA
- Transcription factor MYB3R-3
- Protein ALWAYS EARLY 2
- Retinoblastoma-related protein 1
- Proline-rich family protein
Sequence:
MSIPDPNSSASLTVSPSLSTASETPVTPVNTVRPPPSQPPPAPPPLPPPTYRPIAPLRHPNPFQQQSAYSNNLYAHSIPVRRQIQDPSAVLYPFALPGRGFSARPVRGFVADPSVTAGNLSGYPPRPSFTYDPGPYEQRQMESLLQQFIRERNPQIRPLPRLGLGSPVGLGPIRASPQFLQPRLSSGKISGENARDDPKFLDWSLSRTESDCTVAPPPTSILDTSRNRKARSKDGALAVVRGRKVRITEGSSSLYSLGRSWLKNGAHVGIQPQRSGIMKPLPKPLPVDLTTETSVPDDPDEESADEDKEDEEAVKQLSEKDLLKRHIERAKKVRAQLREERSRRIRRYKERITLILAQSEDR
Protein: UPF0324 inner membrane protein YeiH (P62723)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized HTH-type transcriptional regulator YeiE
- UPF0178 protein YaiI
- Protein RarD
Sequence:
MTNITLQKQHRTLWHFIPGLALSAVITGVALWGGSIPAVAGAGFSALTLAILLGMVLGNTIYPHIWKSCDGGVLFAKQYLLRLGIILYGFRLTFSQIADVGISGIIIDVLTLSSTFLLACFLGQKVFGLDKHTSWLIGAGSSICGAAAVLATEPVVKAEASKVTVAVATVVIFGTVAIFLYPAIYPLMSQWFSPETFGIYIGSTVHEVAQVVAAGHAISPDAENAAVISKMLRVMMLAPFLILLAARVKQLSGANSGEKSKITIPWFAILFIVVAIFNSFHLLPQSVVNMLVTLDTFLLAMAMAALGLTTHVSALKKAGAKPLLMALVLFAWLIVGGGAINYVIQSVIA
Protein: Transcription factor HES-1 (Hairy and enhancer of split 1) (P35428)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- E3 ubiquitin-protein ligase FANCL
- Fanconi anemia group F protein
- Fanconi anemia group G protein homolog
- Fanconi anemia group A protein homolog
- Fanconi anemia group C protein homolog
- Fanconi anemia, complementation group E
- Neurogenin-3
- Recombining binding protein suppressor of hairless
- Neurogenic locus notch homolog protein 2
- Transcription factor HES-5
Sequence:
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMWRPWRN
Protein: Cyclin Y (Cyclin-Y isoform X3) (E7F3H3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Cyclin-dependent kinase 14
Sequence:
MGNSTSCCVSSSPKLRRNAHSRLEPYRPEPELSREDTGCNLQHISDRENIDELNMEYNPSDHPRASTIFLSKSQTDVLLPNKKVREKRKSLYVNHQHPSGPMRRKYSSCSTIFLDDSTVSQPNLKYTIKCVALAIYYHIKNRNVDGRMLLDIFDEKLHPLSKSEVPSDYDKHDPEQKQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNELERQFLELLQFNINVPSSVYAKYYFDLRSLSEANNLSFPLEPLSRDKAQKLEAISRLCDDKYKDLRKAAKKRSVSADNLSVVRWSPAIIS
Protein: Inhibin beta A chain (Activin beta-A chain) (A4D1W7)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
Protein: Antitoxin VbhA (E6Z0R4)
Organism: Bartonella schoenbuchensis (strain DSM 13525 / NCTC 13165 / R1)
Function: Antitoxin component of type II toxin-antitoxin (TA) system VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT.
Interaction partners:
Sequence:
MLSEEEIEYRRRDARNALASQRLEGLEPDPQVVAQMERVVVGELETSDVIKDLMERIKREEI
Protein: Prostaglandin F2 receptor negative regulator (CD9 partner 1) (CD9P-1) (Glu-Trp-Ile EWI motif-containing protein F) (EWI-F) (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD antigen CD315) (Q62786)
Organism: Rattus norvegicus (Rat)
Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity).
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Interaction partners:
- CD9 antigen
- CD81 antigen
- Tetraspanin
- Tetraspanin
- CD151 antigen
- Tetraspanin.
- Tetraspanin
- Tetraspanin
- Tetraspanin
- Tetraspanin.
Sequence:
MGRPAPRPLLLALLSLAVCRGRVVRVPAGTLVRVVGTELVIPCNVSDYDGPSEQNFDWSFSSSGSSFVELASTWEVGFPAQQYRERLQRGDILLRRTANDAVELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTMQVKVLADALVVGPSSRPPPGLSLREGEPFELRCIASTTSPLHTHLALRWELHRGPVHRSILALSHEGRFHPGPGYEQRYHSGDVRLDTVGSDAYRLSVARALSADQGSYRCVVSEWITEQGSWQEIQEKAVEVATVVIQPTALQLAVPRTVSVTEGKDLDLSCNITTDRVDDVRPEVTWYFKKTPDTSLLASHMLARLDRDSLVHSSPHVALSHVDTRSYHLLVRDVSKENSGYYLCLVALWAPGHNRSWHKVAEAMSAPSGVSVTWLEPEYQVYLNASKVPGFSDDPTELQCRVIDTKRVDAGVRLTVSWYYRMNRRNDDVVASELLAVMDGDWTLRYGERSKQRAQDGEFIFSKEHTDTFSFRIQRTTEEDRGSYYCVVSAWTRQRNSSWVKSKDVFSKPVNIFWASEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLITAEKPVGDLSSPNETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAWSPIGGSLWREAATSLSNPIEIDFQTSGPIFNASVHSDTLSVTRGDLIKLFCIVTVDGAVLDPDDMAFDVSWFAVHSFGLDKAPILLSSLDRKGVVTTGQRDWKSTVSLERVSVLEFLLQVHSSEDQDFGNYYCSVTPWVRSPTGSWQREAEIHSRPIFITVKMDVLNAFKYPLLIGVGLSTVIGLLSCLIGYCSSHWCCKKEVRETRRERRRLMSMEMD
Protein: Prokineticin (Prokineticin-2 isoform X1) (Prokineticin-2 precursor) (D3GDN2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Prokineticin receptor 1b
- Prokineticin receptor
- NMDA receptor synaptonuclear signaling and neuronal migration factor
- Anosmin 1a.
- Uncharacterized protein.
- DNA helicase
- Anosmin 1b
- Type II GnRH receptor
- Heparan-sulfate 6-O-sulfotransferase 1-A
- KISS1 receptor a
Sequence:
MTSNISFFLCLLLVSRGWTAVITGACEKDSQCGGGMCCAVSLWIRSLRMCIPMGQEGEDCHPMSHKVPFFGKRLHHTCPCLPNLACITTADGKSKCLPPFPFQDQYL
Protein: Intracellular protein transport protein USO1-like protein (F4I5B1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKSKEEEEEEEEEDDGGEGQKGKRFIEKLRRRAVFVGHRSVFRRPSTPVHISFNPNKNPSSASSRKLAASLWEFYQYYDNDHLIHPPAATKMHRAPLGSAGPSNSRRLRHGHGKAAVADNNGIELTDHQPESAGSIRRQIGQMLMKHHHLTERNDHALQPVSPTSYDSSLEFRGRRRAGEPNNNIKTSTELLKVLNRIWILEEQHSANISLIKSLKTELAHSRARIKDLLRCKQADKRDMDDFVKQLAEEKLSKGTKEHDRLSSAVQSLEDERKLRKRSESLYRKLAQELSEVKSTLSNCVKEMERGTESKKILERLCDEFAKGIKSYEREIHGLKQKLDKNWKGWDEQDHMILCIAESWLDERIQSGNGSALEKLEFEIETFLKTNQNADSNEIARNRRTSLESVPFNAMSAPIWEVDREEEEDSGGSGSNCFELKKHGSDVAKPPRGDETEKPELIKVGVSERPQRRSQSPSSLQVKFEDQMAWAMSSNEKKKTRANEMEPETEKCGKETNNVVGEMIRTHRRLSSETREIDEASCSYPSRRRESPIRQWNTRTVTPDLGAPRGVKDNTLKTKLSEARTTSSRPRVRLFKD
Protein: Translocation protein SEC62 (X2J9A4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
Sequence:
MSEKKRARRRKDEYTEPGAQKVDKPSKDEKNVAKWLKKNVKTKKTKFLSHIVEYFTSSKAIDALLKSKFTEGSNPLFTTREQVIEFLDVMLEHKFFHRAKKVPVTLEEIRGKSGGDKKADKEKTQDKEKDKAKDEKKDTDPEGDNGQGDGGASGNEKEKEKKEKKKRKIRLDMHPEQIFVDGSEAYVWIYDPIPLHYWIFGFILLLGAVGICLFPLWPPLLRKGVYYLSIAAAGFLVFILALTIVRLIVFIIVWALTGGKLHFWIFPNLTEDVSFFASFWPLYESNYNSDPNNSSAKTDKKSKSKDKKKEKESDAEDTAVDADGDADGDVDAEVSTLEPEKIELIKEHDTDMEIRKRRKVGADDYEEDDVDEEETKAQPKDSKAG
Protein: Epididymis secretory sperm binding protein (Kruppel-like factor 5 (Intestinal)) (Q5T6X2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATRVLSMSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAALFPGEELKHAHHRPQAQPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLTPQLPPVPIIPEHKKYRRDSASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPPAPTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMPSSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVKQFQGMPPCTYTMPSQFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYNRRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDELTRHYRKHTGAKPFQCGVCNRSFSRSDHLALHMKRHQN
Protein: Phosphorelay intermediate protein rdeA (Hpt domain-containing protein rdeA) (Rapid development protein A) (Q54RR8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Phosphorelay protein that supplies phosphate to regA or accepts phosphate from regA; depending on the relative concentration of the phosphodonor proteins. In vitro, acts as a substrate for cheA (bacterial kinase). Plays a role in the development. ypd1 (yeast) can complement rdeA defect.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9582274}.
Interaction partners:
- 3',5'-cyclic-nucleotide phosphodiesterase regA
- Hybrid signal transduction protein dokA
- Hybrid signal transduction histidine kinase C
Sequence:
MISDYEGPTPTKKFDQDILFDYSEGEKEFTFELLDSYISSVEEHLPELLNSFEAKDLKGAVLHSHDIKGSSSYIGCEAVRYVSGKIEAYCKNDELEKAESFYPELKKEVEEVFKILSDFKKNWDKNHGEGGSDDGGDDNESEPTENNNNDGSSVNNNDSSSGGGGKDIENKNTDENTGKNLNERSKSPVPLQTTLKPVTIETPKTASDKIATETPTSLANNTNSSSNNNSKNENGLNSKQPQTSSNSPTKIQTK
Protein: Cationic amino acid transporter 3 (CAT-3) (CAT3) (Cationic amino acid transporter y+) (Solute carrier family 7 member 3) (Q8WY07)
Organism: Homo sapiens (Human)
Function: Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine. The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Solute carrier family 7 member 13
Sequence:
MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSRKSRAKTVDLDPGTLYVHSV
Protein: Carboxypeptidase Q (E5RJZ7)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKFLIFAFFGGVHLLSLCSGKAICKNGISKRTFEEIKEEIASCGDVAKAIINLAVYGKAQNRSYERLALLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLEKVHLEPVRIPHWERGEESAVMLEPRIHKIA
Protein: DNA polymerase Y family protein (Q92ZJ7)
Organism: Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Interaction partners:
Sequence:
MVIARSGSKRWISAADTAATKLGLRVGMPAAKAQALVQGLVMIDADTAADLAALERLALWAFSQYSPVVAMDPPDGIVMDTEGADHLQGGEDLMLSSLVNRFRGRGLAARAAIADTWGAAHALARTTDRETVIVGRGDAARAANRLPLSSLRLPAETVQSLRTLGFTTVGDLAATPRAPLTLRFGLEVGRRLDQMFGHIAEPIDPIRPAELVEVQKSFAEPIGAPETIEKYVSRLVRQLCLELERRGLGVRRADLIVHRVDNTIQALRAGTAKPVRDIAWLTKLFRDRIDRIEPGFGIEKLGLAAILAEPLIEAQSASSLIEEQVTDVTPLIDVLGNRGGQRIFRVAPVASDVPERSVRRIAPIADEDGATWPLNWPRPPRLLARPELIEVIALLPDHPPVSFTWRSKRRRVKRADGPERIFGEWWKHSSEWVAVRDYFVVEDDRGERFWIFRSGDGVDAETGSHKWFMHGMFA
Protein: T-cell immunoreceptor with Ig and ITIM domains (V-set and transmembrane domain-containing protein 3) (P86176)
Organism: Mus musculus (Mouse)
Function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q495A1}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q495A1}. Note=Clustered to the immunological synapse where it disrupts granule polarization and cytotoxicity of NK cells once engaged with PVR. {ECO:0000250|UniProtKB:Q495A1}.
Interaction partners:
- Nectin-2
- Poliovirus receptor
- Nectin-3
- Programmed cell death 1 ligand 1
- Galectin-9
- CD226 antigen
- Lymphocyte activation gene 3 protein
- T-lymphocyte activation antigen CD80
- Hepatitis A virus cellular receptor 2 homolog
- Cytotoxic T-lymphocyte protein 4
Sequence:
MHGWLLLVWVQGLIQAAFLATAIGATAGTIDTKRNISAEEGGSVILQCHFSSDTAEVTQVDWKQQDQLLAIYSVDLGWHVASVFSDRVVPGPSLGLTFQSLTMNDTGEYFCTYHTYPGGIYKGRIFLKVQESSDDRNGLAQFQTAPLGGTMAAVLGLICLMVTGVTVLARKDKSIRMHSIESGLGRTEAEPQEWNLRSLSSPGSPVQTQTAPAGPCGEQAEDDYADPQEYFNVLSYRSLESFIAVSKTG
Protein: Putative high affinity immunoglobulin gamma Fc receptor IB (IgG Fc receptor IB) (Fc gamma receptor IB pseudogene) (Fc-gamma RIB) (FcRIB) (hFcgammaRIB) (Q92637)
Organism: Homo sapiens (Human)
Function: May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1430234}; Single-pass type I membrane protein {ECO:0000269|PubMed:1430234}.
Interaction partners:
- High affinity immunoglobulin gamma Fc receptor I
Sequence:
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFMEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISQYTVKGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWNLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT