Protein: Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) (Mediator complex subunit sur-2) (Q10669)
Organism: Caenorhabditis elegans
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Functions downstream of receptor let-23 and let-60/Ras during vulval induction likely by down-regulating the expression of phosphatase dep-1 and lin-12/Notch in vulva precursor cell descendants with a primary cell fate. Acts to repress beta-catenin target genes. Required for asymmetric division of T-cells. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 4
Sequence:
MTDKPGSAEDTIEMDDTCSPQFVQEVNRIKSQIKSLVEENHTRKFFRPLTSNIGDETAILRIQFNNMMSKMEEKEKQSLVKELIKMVHHVAEKNSPDRVFVGTNYERVVDQLLRYAHQKGAISTNLCAEGLIMTSDFRLCSRICQEKWKFINDCIPKIDYKGIRNILRYILESQLRRLPYSLSPEQVNEIRIVENVILHIVDRDSNLMPPLITLSEIMRGMPKQALMLPRLTEKLASLSVHFRPIADLSHVCGRGFVYPIPLHPSFYPLTSCWEEHGLNASNTIVQPHHTLPYRPEHTSTYLYTLYMILRQPLGKDSLHPPSKTKTKTNWEMLISVMICESMAEAESLPETEPIPRYQWDNIVNIVIYGITQHLLVPKTFFNVLKNLIKRCKYTRARDEVMWIVFQVVGSLSNLTRLDDAVTEIVELYNELFDGDVVWMGASDHPALFARFLAAAGTWMILEKDFADKMPPANETIKSHIKFIQDGVDNFDSSNTAMLAVLSNIYRTDTKMGKLIVPTLQQMLESIDDTKSLFELSYKRMAVNCFSAFPVEFMEALTFRSKKTLLIQCFQPLRSFSTVRLPSPAVFETVAKICESEDYEMAVKDMEHLAQRSLHVATAADRSSGEHQNVQAKDQCYFLFDFLVYRLPHLHAYSKYSSTVNALSYFTQHIPNNPQNHQIYRLMEQFLMRRWCWAGFHGCITAHTQMFGTSYKDNTMMRHMAYPKTFSVPDQYPFAINPEIFKMAIYSFLRAVKITAQDIAIEKTMFPTIINGFGWPEKSTSYFPKWALDAIKASDTSNAVNTEEILSDVRNTARMHTSLTPNQFVIRYGEDRDPATSHCMLAVLFHFAYNSVDSTYNITSEFYEVMEKKTPKEIVVMGNYLVDYIIADAKTQDCNEKTFKNIAKAAALLVFQFQVLRADRLLLSLIMHPATDEDALICIQIANEFILTPEFQERIRWYHQNVPKKDHFPTEYIKAIVKYHDAFPEFEACELVRSYDSSSNVHMPTYYGCLIERLLPIMDQYLHVALEQQGYKLNPQILQSVSMLYKFHAMPIHFMYSVLFTSHGLMSGPDAKSFVLAFATQIEECHLTEAFEKFNHQKSSREQLIMELIDRMSASLDFILTPPPFVAKDWKIAELSPGAQTLYLACIELMASPHSPETLVAAMINVMQMKPHARPFNIVNLTALLLTALPAAYSNALHDEFVAVFVNGETANLKFEEIVFDNYEESLLLNLPNRARTINVISQQYWLHCSLSLLNFFSHEYVPRILEHVKTEKDLWYTLRLVMPYLRRYYENWDTAKQMRSQRENFGPLHIVKLVFQKLGSMAEEGVEIVYEQHLCDLFYNCKYFFAGDFLRNTAITEFAKLPEKMRDRLKFYVSQSEPTAEQETPPEKEKSPEKEKEQEQEQHVKAHQPLESTPSVSSLPQMQHHLQQAPLLPSHQMMPPPQQHSSSLQHHLQHHTSTHQMMDTSQHQTIQQQSNHPTQQQLQHQIPNMSMHQQMGPQYPGAVFHHPSGPVGHVPMQYGMGHHMQQHPHLPHHQQMPAPMHTMNPMMQNMTPQQQYLYMQQLQQHQQHQQYMQQQQQHHHQHQQQPH