wanglab/gogpt-training-data huggingface dataset:
Protein: Ribosomal RNA large subunit methyltransferase I (EC 2.1.1.191) (23S rRNA m5C1962 methyltransferase) (rRNA (cytosine-C(5)-)-methyltransferase RlmI) (P75876)
Organism: Escherichia coli (strain K12)
Function: Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. Methylation occurs before assembly of 23S rRNA into 50S subunits.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Ribosomal RNA small subunit methyltransferase F
- Heat shock protein HspQ
- Ribosomal RNA small subunit methyltransferase B
- 23S rRNA
- Acylphosphatase
Sequence:
MSVRLVLAKGREKSLLRRHPWVFSGAVARMEGKASLGETIDIVDHQGKWLARGAYSPASQIRARVWTFDPSESIDIAFFSRRLQQAQKWRDWLAQKDGLDSYRLIAGESDGLPGITIDRFGNFLVLQLLSAGAEYQRAALISALQTLYPECSIYDRSDVAVRKKEGMELTQGPVTGELPPALLPIEEHGMKLLVDIQHGHKTGYYLDQRDSRLATRRYVENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKLDLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQLMGACRGYKDINMLAIQLLNEGGILLTFSCSGLMTSDLFQKIIADAAIDAGRDVQFIEQFRQAADHPVIATYPEGLYLKGFACRVM
Protein: Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2) (O88801)
Organism: Rattus norvegicus (Rat)
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17584991}. Cell membrane {ECO:0000269|PubMed:17584991}. Postsynaptic density. Synapse. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q9QWW1}. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
Interaction partners:
- Homer protein homolog 1
- Homer protein homolog 3
- Metabotropic glutamate receptor 1
- Metabotropic glutamate receptor 5
Sequence:
MGEQPIFTTRAHVFQIDPSTKKNWVPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVREAARLARDKSQEKIETSSNHSQESGCETPSSTQASSVNGTDDEKASHASPADTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRSKIEELEEQCGEINREKEKNTQLKRRIEELESEVREKEMELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKGELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Protein: Competence and sporulation stimulating factor (CSF) (Extracellular signaling peptide CSF) (RapC inhibitor) (P94416)
Organism: Bacillus subtilis (strain 168)
Function: Signaling molecule that serves as a cell density signal for both genetic competence development and sporulation. Secreted during production, but the mature peptide acts intracellularly, indicating that it needs to be imported into the cell to function. At low concentrations, CSF stimulates expression of the genes controlled by ComA, a transcriptional factor that regulates the development of genetic competence. It includes the srfA operon, which encodes a small protein, ComS, required for competence development, and the surfactin biosynthetic enzymes. Acts by inhibiting RapC, which regulates the activity of ComA. At high concentrations, it inhibits expression of those same ComA-controlled genes, maybe by inhibiting activity of the kinase ComP. In addition, high concentrations of CSF can stimulate sporulation under some conditions. Also inhibits RapB activity, with lower efficiency, but does not act on RapA. Is probably involved in the quorum sensing control of sporulation (Probable). CSF is a species-specific signaling molecule that partially compensates for the lack of ComX-mediated communication between different strains of B.subtilis.
Subcellular location: Secreted {ECO:0000269|PubMed:8769645, ECO:0000269|PubMed:9200610}. Cytoplasm {ECO:0000269|PubMed:8769645, ECO:0000269|PubMed:9200610}. Host cell {ECO:0000269|PubMed:18005709}. Note=Produced through an export-import maturation process (PubMed:8769645, PubMed:9200610). Peptides are secreted by the bacterium, and are then actively transported into the cell where they interact with intracellular receptors to regulate gene expression (PubMed:8769645, PubMed:9200610). Transported into the cell by the Opp (Spo0K) oligopeptide permease (PubMed:8769645, PubMed:9200610). In human gut, is transported into the intestinal epithelia by OCTN2 (PubMed:18005709). {ECO:0000269|PubMed:18005709, ECO:0000269|PubMed:8769645, ECO:0000269|PubMed:9200610}.
Interaction partners:
- Regulatory protein RapC
- Response regulator aspartate phosphatase J
- Response regulator aspartate phosphatase B
- Regulatory protein RapF
- RapF inhibitor
- Phosphatase RapA inhibitor
- Sensor histidine kinase ComP
- Phosphatase RapE inhibitor
- RapK inhibitor
- Surfactin synthase subunit 1
Sequence:
MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT
Protein: Mitogen-activated protein kinase kinae mkk2 (MAPKK mkk2) (EC 2.7.11.24) (MEK mkk2) (Q4WJJ0)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Mitogen-activated protein kinase kinase; part of the cell wall integrity (CWI) signaling pathway composed of pkcA, the bck1-mkk2-mpka MAPK cascade and the downstream rlmA transcription regulator. The CWI signaling pathway regulates cell wall integrity and pyomelanin formation. CWI controls also oxidative stress response, gliotoxin production, iron adaptation and asexual development. Finally, CWI is constitutively required for A.fumigatus to cope with the temperature increase found in the mammalian lung environment, during infection. Mkk2 directly activates mpkA during vegetative growth and under cell wall stress conditions.
Interaction partners:
- Mitogen-activated protein kinase kinae kinase bck1
- Mitogen-activated protein kinase mpkA
- MAP kinase kinase kinase SteC
- Mitogen-activated protein kinase mpkC
Sequence:
MSSSPVPLLRPPVPGNRGNGPRPPKLTLGIPPSPNSRPVDGNGVGPAAAAPEAPQPQRPSTRPAPPQLRLATPMGSSSDVPQEVPRLANGRPAPPPLATTGLNESTGHSRSSSFTYLDGKASGPASASSSNYSALSFAMGLRQPHGSTPDPSSAISSVYSDREGGVQMERDNSVNGLLPDLDKLSLEKGRPLDVDDLDDEGWLAASEQKKIIELGSLGEGAGGAVTRCKLKDGKTVFALKIITTDPNPDVKKQIVRELNFNKDCASEHICRYYGAFMDKSTGTISIAMEFCEGGSLDSIYKEVKKLGGRTGEKVLGKIAEGVLNGLTYLHSRKIIHRDIKPSNILLCRNGQVKLCDFGVSGEFGTKGDANTFIGTSYYMAPERITGQSYTITSDVWSLGVTLLEVAQHRFPFPADGTEMQPRAGLIDLLTYIVRQPIPKLKDEPENRIRWSDNFKYFIECCLEKEPPRRATPWRMLEHPWMLDMKNKKVNMANFVRQVWGWQD
Protein: Chromatin-remodeling complex subunit ies6 (Q9UTE8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- RuvB-like helicase 2
- RuvB-like helicase 1
- Actin-like protein arp5
- Probable actin-related protein 8
- INO80 complex subunit 4
- INO80 complex subunit 3
- INO80 complex subunit 1
- Actin-related protein 4
- Chromatin-remodeling ATPase INO80
- SWI/SNF and RSC complexes subunit arp42
Sequence:
MEKNSSVDSLDISLLARPFRNPNYKAQPRRNRNLRQIIQNDPVQNEPSKFSYSSIEAPPSVLPQPKYCDVTGLLAIYTDPKTRLRYHNKEIYGLIRELPSGADQEYLKLRSSDVVLK
Protein: Actin-like protein ARP10 (Q04549)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Pointed-end-associated component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. May regulate the association of the dynactin complex with the plasma membrane.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Nuclear migration protein JNM1
- Centractin
- Endoplasmic reticulum membrane protein complex subunit 10
- Actin
- Protein NIP100
- Protein LDB18
- Actin-related protein 4
- F-actin-capping protein subunit beta
- Actin-related protein 3
- Actin-related protein 2
Sequence:
MSNTIVIVYLGANRIEIGRSADACPQEIIAWKTGSINEKNREELKKIFEHYFQICNILGNREVQVLILEDIFISVVEKRIICSILFKEFDCAHVSFVPRAIVHCLSCNTRNAIVIDIGTNYTTCVPIFDLRPLQQFIKYSKRGKRQVESRIPLPGSLYMPIFFDEEYNSKNCEVDETPVINLVKNIVESLPIDLRRPLRENIIIVNIEEAYETVIRNLFKLKMDTSKIQFPKNYWQAGSACAKILLHYKGSNIVGIERDEFYNNPHIAPDWFDYYFRTGVKRLQ
Protein: eIF-4F 25 kDa subunit (Q9W5B3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Eukaryotic initiation factor 4A
- Eukaryotic translation initiation factor 4G1, isoform B
- Polyadenylate-binding protein
- Eukaryotic translation initiation factor 4E-binding protein
- Eukaryotic initiation factor 4B
- ATP-dependent RNA helicase
- Cytoplasmic FMR1-interacting protein
- ATP-dependent RNA helicase me31b
- Eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 4 gamma 2
Sequence:
MLPNSFYRMRDFANPRTMFKSCANNNEYPTQGPQKVESPTDVTQPAAAPQSTEDTQPEKTQEPMNDPNKTSPSEPQKRGKGNRKGKKNQKNAPRTPSQTSKSSRSNNPGKDGKSTGNDDNEKGKGQGKQMVQQKENSPEQEQSTSAQYRKNVLDKDLQDKKLIEKNMQGKIITQENLLGQKVLMRLSEQKLLSLRLEPRIKQNTCPPAKKEDAVVAFDNSLEFLSLNNKCDDDLTIAAENAELLEVEDPQHPLNNCWTLWYLENDRNKSWEEMLHKVTSFDTVEKFWSLITHIKPPSELMLGSDYSLFKKGIRPMWEDEANVNGGRWVINLTKSAKMALDSFWMDAMLCLIGEACKHSDDLCGVVVNIRGKSNKISIWNADGGNQTTVLEIGRILRKVLRMDNIYVLEYQLHKDSKDKLGSTVKRIYTV
Protein: Protein BONZAI 2 (Q5S1W2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Negative regulator of cell death and defense responses. May repress a number of R genes and may have effects in promoting growth and development. May function in membrane trafficking and in fusion of vesicles with plasma membrane (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Protein EXORDIUM-like 4
- Protein SMALL AUXIN UP-REGULATED RNA 10
Sequence:
MGSCWSDGSYAGGGMVGVGGGANSSAATPNDAVDYYLKSRGYNGLFSQIELSFSASNLRDRDVISKSDAMVVVYTKGRDGTLAELFRSEVVLNSLNPKWIKNFTIGYQFEIVQTLLFRVYDIDTQFQNSKEELLKLDEQQFLGEATCTLSEVVTKSNRTIALELMRKEGVAAQTQPQHNGKLIVHAEESLASKTNTEIVFRGLNLESKDTFSKSDPFLVISKIVEHGTPIPVSKTEVLKNDPNPLWKPVSLSVQQVGSKDSPLVIECLDFNGNGNHDLIGKVQKSLSDLEKLHLAGQGINLALPTGVGHKHEDRVLKSQLFVDKFTETVQHTFLEYLASGFELNFMVAIDFTASNGNPRLPDSLHYIDPTGRLNAYQRAIVEVGEVLQFYDSDKRFPAWGFGARPIDIPVSHCFNLNGSSTYCEVDGIQGIMNAYNGALFNVSFAGPTLFGPVINAAATIASDSLAQSAKKYYVLLIITDGVITDLQETRDSIVSASDLPLSILIVGVGGADYKEMEVLDGDKGEKLESSSGRIASRDIVQFVALRDIQYGEVSVVEALLAELPTQFLTYMRNRNITPTTTTPSST
Protein: Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] (Q12912)
Organism: Homo sapiens (Human)
Function: Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules.
Subcellular location: [Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm {ECO:0000250|UniProtKB:Q60664}.; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q60664}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q60664}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5RHB5}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q5RHB5}. Chromosome {ECO:0000250|UniProtKB:Q5RHB5}. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q60664}.
Interaction partners:
- Protein KASH5
Sequence:
MESTPFSGVANQIHTLCERPTYGEVKDGALDVKRQHKCPGPTSGPSPGTNLSGCIRMNDDPSMEENGVERVCPESLLQSREYSSLPLPRHTSSTDGTITSSDPGLEILNMASCDLDRNSLCKKEEDTRSASPTIEAQGTSPAHDNIAFQDSTSKDKTILNLEAKEEPETIEEHKKEHASGDSVVSPLPVTTVKSVNLRQSENTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPLCEDDNQAQEIIKKLEKSIKFLSQCAARVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQNERSFNPLEDDDDCQIKKRSASLNSKPSSLRRVTIASLPRNIGNAGMVAGMENNDRFSRRSSSWRILGSKQSEHRPSLPRFISTYSWADAEEEKCELKTKDDSEPSGEETVERTRKPSLSEKKNNPSKWDVSSVYDTIASWATNLKSSIRKANKALWLSIAFIVLFAALMSFLTGQLFQKSVDAAPTQQEDSWTSLEHILWPFTRLRHNGPPPV
Protein: RNA exonuclease 5 (EC 3.1.-.-) (Exonuclease NEF-sp) (Q96IC2)
Organism: Homo sapiens (Human)
Interaction partners:
- Oligoribonuclease, mitochondrial
- RNA exonuclease 1 homolog
Sequence:
MEPEREGTERHPRKVRESRQAPNKLVGAAEAMKAGWDLEESQPEAKKARLSTILFTDNCEVTHDQLCELLKYAVLGKSNVPKPSWCQLFHQNHLNNVVVFVLQGMSQLHFYRFYLEFGCLRKAFRHKFRLPPPSSDFLADVVGLQTEQRAGDLPKTMEGPLPSNAKAAINLQDDPIIQKYGSKKVGLTRCLLTKEEMRTFHFPLQGFPDCENFLLTKCNGSIADNSPLFGLDCEMCLTSKGRELTRISLVAEGGCCVMDELVKPENKILDYLTSFSGITKKILNPVTTKLKDVQRQLKALLPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFKLKFLAKVILGKDIQCPDRLGHDATEDARTILELARYFLKHGPKKIAELNLEALANHQEIQAAGQEPKNTAEVLQHPNTSVLECLDSVGQKLLFLTRETDAGELPSSRNCQTIKCLSNKEVLEQARVEIPLFPFSIVQFSFKAFSPVLTEEMNKRMRIKWTEISTVYAGPFSKNCNLRALKRLFKSFGPVQSMTFVLETRQPHLCIQYEVLEAAQLAIESLDGILVDGICIKVQRPVTELTLDCDTLVNELEGDSENQGSIYLSGVSETFKEQLLQEPRLFLGLEAVILPKDLKSGKQKKYCFLKFKSFGSAQQALNILTGKDWKLKGRHALTPRHLHAWLRGLPPESTRLPGLRVVPPPFEQEALQTLKLDHPKIAAWRWSRKIGKLYNSLCPGTLCLILLPGTKSTHGSLSGLGLMGIKEEEESAGPGLCS
Protein: Neuronal PAS domain protein 3 isoform D (X5D988)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEALQRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNFVDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTLPFPVYSNGIHAAQTLERKED
Protein: Selenoprotein (Q8ILJ2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MDTNENMKNVKDMMSFTTKNIIYIFIGISLLIFIYKILKKNKKDAEVKRNNEISIKMKLSREKQLQELDKEMMINKEKMKEQNIKKNEEKKKDADQAKPKLGSKDNSSFNHLNDYSNYYRPSLKNRYNNRKSUR
Protein: Ammonium transporter (G5EB13)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362002}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362002}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Histone H3
- Nitrate transporter
Sequence:
MSTYPVAYNGTGVNGGDSLREDLNIYYSSGDIAWVITSTALVLLMIPGVGFFYSGLARRKSALSLIWLSLMSIGVVSFQWFFWGYSLAFSHTAGKYIGNLDNFGFKGVLGAPSVGSTKVPDLLFAVFQGMFAAITVALAVGAVAERGRMLPCMVFVFIWSTIIYDPVACWTWNASGWVFQLGGLDFAGGTPVHIVSGTTALAYSLMLGKRRGHGTHELNYRPHNVTHVVIGTVFLWVGWFGFNAGSALSANLRAVMAAVVTNLAASVGGVTWCLLDYRLERKWSTVGFCSGVISGLVAITPGSGFVTPWAAFIFGVVGAAACNFATKVKYLIRVDDALDIFAVHGIGGLVGNLLTGLFAADYIAHLDGSTEIDGGWINHNYIQLGYQLADSVTGMAYSFFGSCIILFIINMIPGLSLRVPEEDEVLGIDDAEIGEFAYDYVELTRDVINGTTEPMDGASKRSTTPTGPVEPSPAELKA
Protein: Microfibrillar-associated protein 5 (MFAP-5) (Microfibril-associated glycoprotein 2) (MAGP-2) (Q9QZJ6)
Organism: Mus musculus (Mouse)
Function: May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity. Component of the elastin-associated microfibrils (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Fibrillin-1
- Microfibrillar-associated protein 2
- Elastin
- Protein jagged-2
- Fibrillin-2
- Lysyl oxidase homolog 1
- Fibulin-5
- EGF-containing fibulin-like extracellular matrix protein 2
- Fibulin-2
- Microfibril-associated glycoprotein 4
Sequence:
MLFLGQKALLLVLAISIPSDWLPLGVSGQRGDDVPETFTDDPNLVNDPSTDDTALADITPSTDDLAGDKNATAECRDEKFACTRLYSVHRPVRQCVHQSCFTSLRRMYIINNEICSRLVCKEHEAMKDELCRQMAGLPPRRLRRSNYFRLPPCENMNLQRPDGL
Protein: Epidermal growth factor receptor pathway substrate 15 (E9PSY8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Epsin-3
- Epsin-1
- Epsin-2
- Intersectin-1
- Stonin-2
- Intersectin 2
- Clathrin heavy chain 1
- Epidermal growth factor receptor substrate 15-like 1
- AP-2 complex subunit beta
- Receptor protein-tyrosine kinase
Sequence:
LVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLNKQEFFIALRLVACAQNGLEVSLSSLNLAVPPPRFHDSSSPLLTSGTSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSTLLAHIWALCDTKNCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDKSSLQKNTIGSSPVADFSAIKELDTLNNEIIDLQREKNNVEQDLKEKEDTVRQRTTEAQDLQDEVQRESLNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAEITSQESQISTYEEELSKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRLAMKDLETDNNQSNWCSSPQSILVNGAADYCSLSTSSSETANLNEHAEGQNNLESEPIHPESSVRSSPEIAPSDVTDESEVVTAADIEKVSPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFATSSTDPFSASSNSSNTSVETWKHNDPFAPGGTVVAATDSATDPFASVFGNESFGDGFADFSTLSKVSNEDPFNPTISSSASSVVIPKPVLEETPSKSEDVPPALPPKTGTPTRPCPPPPGKRPINKLDSSDPFKLNDPFQPFPGNDSPKEKDPDMFCDPFTSSSTTANKEAEPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
Protein: Calcineurin binding protein 1 (G3X8Q1)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Ubinuclein-1
- Protein HIRA
- Histone chaperone ASF1A
- Myocyte-specific enhancer factor 2B
- Ubinuclein-2
- Myocyte-specific enhancer factor 2D
- Ubiquitin-like protein FUBI
- E1A-binding protein p400
- Calmodulin-like protein 4
Sequence:
MIRIAALNASSTIEDDHEGSFKSHKIQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEARLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCDMSIHDVSVSAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFFTWKCLGESLLAMYSHLTTCEPPRPSLGKRIDLSDYQDPSQLLASSVVVTPVSVVQPSPICTNPTVAVAEPVLSYTSVTAASFPLHSPSLLDTGTPMGDVSGGDKSKKGVKRKKTVEESGETAKRRSARVRNTKCKKEEKVDFQGLLVKFLPSRLRKLDPEEEDDPFNNYEVQAEAKLESFSNVGPHRLSFDSATFMESEKQDVHAFLMENLTNGGLLELMMRYLKSMGHKFLLKWPPGLADVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKDMMLMSLSCMELQLDQWLLTKGRSSAVSPRNCPAGVVTGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQGDMEQALENYDICTEILQSSSAIQAQAGAEQGDIVIRLPNLHNDSVVSLEEIDKNLKSLERCQSLEEIQRLFEAGDYKAVVHLLRPTLCTSGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLKDHRQCFECSDVALNEAVQQMLNSSESAAKEEWVATVTQLLLGIEQALSSDSSGSILKESSSTTGLVRLTNNLIQVIDCSMAVQEEPKEPYVSSVLPWIILHRIIWQEEDTFRSLCHQQQLQNPTEEGIPEMPMLPSSLMLLNTAHEYLGRRSWCCNSDGALLRFYVQVLQKELAASASEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVDLIWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTEKPALSMDKVSAYIEGTSAEAPCLPEGADPTPPVLNELYYLLADYHFKNKEQSKAIKFYMHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNCFRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRSELPPELVQQMEDRRDSMLETARHCFTSAARCEGDGDEEEWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEALEVYFRLHASILKLLGKPDSGVGAEVLVSFMKEAAEGPFARGEEKNTPKASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPGLTSPPYTATPIDHDYVKCKKPHQQAAPDDRSQDSTAVALSDSSSTQDFFNEPTSLLEGSRKLFPEKRLSGLSAQAGPSGKDLPGPTEERGKTEESLESTEAFRVVEQSVQKPVADSSASAYIPSKPPASTPPLWDGKKRGDSLGEPVAFPQGLPAGAEEQRQFLTEQCISSFCLCLSRFPQHYKSLYRLAFLYTYSKTHRNLQWARDVLLGSSIPWQQLQHMPAQGLFCERNKTNFFNGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTLSELAEGSEHPGSKACGLSGARMTTDVSHKASPEDGQESPQHPKKLPLADGSGPGPEPGGRMGPLNQLPVVTDIRDNTDQGGEQKDKESPQVGPTEPMDTSEAAGRHSDLEQTSRLLPGRPPRDRGPESRSAELSLEELSISTRQQPAPLAPSPAAPTTTAAPTTMAARGAGHSEEAPPRPNRKRKLLEDTESGKTLLLDAYRVWQQGQKGMAYDLSRIEKIMSETYMLIKQVDEETALEQAVKFCQVHLGAATQRQASGDTPTTPKHPKDSRENFFPATVVPTVPDPTAPDALQRPSDSHLKPVLATVITCPPSASASIPDLSTDPGIPRPHRPETTPSRAPLSPEGEEASGVTEGTSILPQEPRYSHQIKMAATGHLAEQHCWPVEVACQTGAEPTCSQASSTKVPSSGSTQTAESHQGKTESSRAKSRLLPNMPKLVIPSATTKSPPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESLCQPALEVLETSSQESSLESETDEDDDFMDV
Protein: AT-rich binding protein (A/T-stretch binding protein) (Q26635)
Organism: Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)
Function: May be a transcription factor for genes having (A+T) stretches in their promoter and/or enhancer regions. Binds to AT rich DNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:7607207, ECO:0000269|PubMed:8307011}.
Interaction partners:
Sequence:
MGFPRIISKNNKIYTKLGAFCLSGDGQQFWIVCHTCQEELQTQDKFWKHIQDEHNFMHGPKQEQGRTAAQAYMEAAEAAAMTPLPLYRKVSENDQQRDDVVSTEDEDMQKEPKDYTEMRAHDDQQQTAAVAIDIKLEPSSLSQQSAVQAQQQQQQQQQQQQQQQQQQQQQEQLQQQQQQQQTQQIEITTPLMYQIPQVHPPVSAYAALVQAPAINTLNMSVAAAAAAVASNQVPSTMANLLPQELQYKQELQYKQEVQQHKESTNNSTTASASSAMSSDDGERFYICDFENCGLKFKYHSRLELHRSVHSKVRRFACEICGASFKQSCNLSTHRKKKHALKGTTKATLVPSQSF
Protein: 4-aminobutyrate aminotransferase (EC 2.6.1.19) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (O13837)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source. Deaminates GABA to succinate-semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase. Cannot transaminate beta-alanine (BAL).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Succinate-semialdehyde dehydrogenase [NADP
- Succinate-semialdehyde dehydrogenase [NADP
- Aspartokinase
- Putative aldehyde dehydrogenase-like protein C922.07c
- Putative aldehyde dehydrogenase-like protein C9E9.09c
- Pantoate--beta-alanine ligase
- Probable acetyl-coenzyme A synthetase
- Protein arg11
- NADP-specific glutamate dehydrogenase
- Putative alanine aminotransferase
Sequence:
MSSTATVTESTHFFPNEPQGPSIKTETIPGPKGKAAAEEMSKYHDISAVKFPVDYEKSIGNYLVDLDGNVLLDVYSQIATIPIGYNNPTLLKAAKSDEVATILMNRPALGNYPPKEWARVAYEGAIKYAPKGQKYVYFQMSGSDANEIAYKLAMLHHFNNKPRPTGDYTAEENESCLNNAAPGSPEVAVLSFRHSFHGRLFGSLSTTRSKPVHKLGMPAFPWPQADFPALKYPLEEHVEENAKEEQRCIDQVEQILTNHHCPVVACIIEPIQSEGGDNHASPDFFHKLQATLKKHDVKFIVDEVQTGVGSTGTLWAHEQWNLPYPPDMVTFSKKFQAAGIFYHDLALRPHAYQHFNTWMGDPFRAVQSRYILQEIQDKDLLNNVKSVGDFLYAGLEELARKHPGKINNLRGKGKGTFIAWDCESPAARDKFCADMRINGVNIGGCGVAAIRLRPMLVFQKHHAQILLKKIDELI