wanglab/gogpt-training-data huggingface dataset:
Protein: CLAVATA3/ESR (CLE)-related protein 10 [Cleaved into: CLE10p] (Q4PSX1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular location: [CLE10p]: Secreted, extracellular space {ECO:0000250|UniProtKB:O49519}.
Interaction partners:
- Receptor-like protein kinase HSL1
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- Somatic embryogenesis receptor kinase 1
- CLAVATA3/ESR
- Leucine-rich repeat receptor-like serine/threonine-protein kinase RGI4
- CLAVATA3/ESR
Sequence:
MKTNRNRPINILIVFFLLTTARAATRNWTNRTHRTVPKVQHAYYAYPHRSCESFSRPYARSMCIELERIHRSSRQPLFSPPPPPTEIDQRYGVEKRLVPSGPNPLHN
Protein: Gallinacin-13 (Gal-13) (Beta-defensin 13) (Gallinacin-11) (Gal-11) (Q6IV18)
Organism: Gallus gallus (Chicken)
Function: Has bactericidal activity. Potent activity against E.coli, L.monocytogenes, S.typhimurium and S.pyogenes but mot against S.aureus.
Subcellular location: Secreted. Cytoplasmic granule {ECO:0000250}.
Interaction partners:
- Gallinacin-8
- Gallinacin-12
- Gallinacin-1
- Gallinacin-9
- Gallinacin-6
- Gallinacin-10
- Gallinacin-11
- Gallinacin-14
- Gallinacin-3
- Gallinacin-5
Sequence:
MRILQLLFAIVVILLLQDAPARGFSDSQLCRNNHGHCRRLCFHMESWAGSCMNGRLRCCRFSTKQPFSNPKHSVLHTAEQDPSPSLGGT
Protein: F-box protein COS111 (Ciclopirox olamine sensitivity protein 111) (P38308)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: F-box protein probably involved in ubiquitin conjugation pathway. Involved in the resistance to ciclopirox olamine (CPO), a synthetic antifungal agent.
Interaction partners:
- Uncharacterized protein YBR071W
- Putative uncharacterized protein YBL012C
Sequence:
MSSASRLQNVNIVSNNYSRYGTSVYDKLYHSNGSGSNNAGKNSTTVGKLSSISQKSRSKQRHGSNCSRSMSQSPLSTFKSPLSNQNQSSAPDDLASIGQRRSDDVTSLDNETIITMNSRKSRIKKKYKSLISTSSKKFMNKLYDHGASSDSFSIFSLKTSHSGKHENSRFEKLRKRKYHAWGKFADINDLPVEIIAKILSEFELGRDQKTLVRCLYVSKKFYKATKIVLYRLPYFTSTYRVAQFVTSLRLHPDNGAYVKVLDLSHLKPGIIGQDSKDSQGLDDDGHSRRHRRRRRRSTNTSLNLPPATPTSTISNEDDANSGLIKDDASNGSEVEDLALAGWRDWRYRNEPLYSSPLLNSFKLKKVVSRSSSITSTSSGNSTGVHSTRRQRSNSSVASITTSIMSSIYNTSHVSLSSTTSNTSNGNISSGSNLSRVSTAGSLKKASAKSTRSSPQKAKPISDITSSSWFRMRLSSRNRKARTANTINLKNSKDKSDDDFKVLKHDSGHPSNYRSSTLKFSIEQPFSTHHPYANKFLLKYAPYKDLPLGYILHMLNLCPNLVELNLSNLVICTDFKLINQRSERRRMTSSLLPAVQESSVSAGPEKDLEIVYMTDSGKGYEYYEGLSKKHSRSSSLGTNPSSWIGGQANWTDYPPPIDAQTKTREEHRRNNTLNNKNVVLKKLNPFEIFEMICNRNEEKGGYCSLTKVKMNDIVWCRQYMVKYFVMRTFRQHLDYKSMENNSYERHLFSFRDSGLDRNFSWACNAKLHEFVALMVMDHLSNLDDLGLEELFNIKSEKLYIKNYCCRDPDILEISNLFDIRYGAGSEADATSDSNLEAESLQFRLTILKTEKPTSFWLTKVSKDYVSLVVKLCVDDDIDMDKMKVGKPTLRIDSITHNLISRLKELRRVDLRRNVGENNYYAESII
Protein: Small ribosomal subunit protein eS17A (40S ribosomal protein S17-A) (O42984)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS14
- Elongation factor 3
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein uL5B
- Small ribosomal subunit protein uS5
- mRNA export factor elf1
- Small ribosomal subunit protein eS27
Sequence:
MGRVRTKTTKRASRVVIEKYYPRLTLDFQTNKRIVDEVAIIASKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEVSELEVDRVNVDQDTKDMLKSLGYDQIPVRVLAPAPQERFRRRQ
Protein: Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) (Q8R0G9)
Organism: Mus musculus (Mouse)
Function: Involved in poly(A)+ RNA transport. Involved in nephrogenesis.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q8WUM0}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q8WUM0}. Note=Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores. {ECO:0000250|UniProtKB:Q8WUM0}.
Interaction partners:
- Nuclear pore complex protein Nup107
- Nuclear pore complex protein Nup160
- Nuclear pore complex protein Nup85
- Nucleoporin SEH1
- Nucleoporin Nup37
- Nuclear pore complex protein Nup98-Nup96
- Protein SEC13 homolog
- Nucleoporin Nup43
- Protein ELYS
- E3 SUMO-protein ligase RanBP2
Sequence:
MFPSVSSPRTPGPGTRRGPLVGIGPTSTPRASRRGLSLGSAVNSPVLFSPAGRRSSVSSRGTPTRIFPHHSISESVNYDVRVFGSSLPVKIMEALTMAEADEQLSVHVDEGGWACLVCTEKLLIWKIAVSPVTKLSVCKELQLPPSDFHGSADLVALSYAATSGEVHSVQAVSVMVATKEGSIRYWPSLAREDTYSDTCVDLGGEKMCRFLTAVQGGSFILSSVGSQLVRLIPESSGKIHQHVLPQGQGMLSGIGRRVSSLFGILSPTSDLMLASVLWDRGGSSFYTLTSSNISKWELDDSSEKQVHSWDVHRTLKESITDAVWGSESNYEAIKEGVNIQYLDLKQNCDGLLILAAAWHLGDSPCLVYYSVITVEDNGNQMSDAVTVEVTQYNPPFQSEDLIACRLMVPNFSSQMTYLYMENAVFVCSTGTGKFSLPQEKIVFDTQGDGILGAGSCAGVPILFSRNSGLVSVTPRENVSLLAEDLEESLTSSVGGRGSESMVFETTTKNETVAHEDKTKLLKAAFLQYCRKDLGRAQIMADELFSSHTDLDSDPELDKAVTQISVDLIDDYPASDPRWAESVPQEAPGLSNTSLIILHQLEDKMKAHCLLVDFLHQVGLFRRLSSYPIRGTPMSTRLLLCEHAEKLSAAITLKNHHSRLPDLVNSAILLALNKRECEVPNSLTPADVFFREVSQVDTICECLLEHEEQVLREVALVSQEWAEVAIDVNTVLKDMLQAATHYRLNKSSMYSQEEVLGKEPEYVPWTATSGPSGIRTAVMRQHGIILKMVYPQADSKLRNVVMEQLVALIDCFLDSYVSQLKSLEKSSDQERYSSLEVEYLQKRSELLSPLLTLGQYPWAASLAEKYCDFDILVQMCEQTDNQARLQRYMTQFADQNFSDFLFRWYLEKGKRGKLLSQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHTTLLGLANMETRYFAKKKTLLGLSKLAALASDISEDRLQEKIEAMAEQERFLLHQETLPEQLLTERQLSLSAMPVLTAPQLISLYICDENRRANEYDFKKALDLLEYIDEEEDVSIDDLKLEILCRALQRDDWSGSDGKDDPIEVSKDSVFVKILQKLIKDGIQLSEYLPEVTDLLRAEQLGSLKSNSYFEFVLKANYEYYVQGQM
Protein: Ras-related protein Rab-5A (EC 3.6.5.2) (Q0IIG7)
Organism: Bos taurus (Bovine)
Function: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}; Cytoplasmic side {ECO:0000250|UniProtKB:P18066}. Early endosome membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}. Melanosome {ECO:0000250|UniProtKB:P20339}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P20339}. Cell projection, ruffle {ECO:0000250|UniProtKB:P18066}. Membrane {ECO:0000250|UniProtKB:P20339}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P20339}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CQD1}. Endosome membrane {ECO:0000250|UniProtKB:P20339}. Note=Enriched in stage I melanosomes. Alternates between membrane-bound and cytosolic forms. {ECO:0000250|UniProtKB:P20339}.
Interaction partners:
- Early endosome antigen 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Rab5 GDP/GTP exchange factor
- Rabenosyn, RAB effector.
- BRMS1 transcriptional repressor and anoikis regulator
- Alsin
- small monomeric GTPase
- Vacuolar protein sorting-associated protein 45
- Ras-related protein Rab-5C
- GTPase-activating protein and VPS9 domain-containing protein 1
Sequence:
MANRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSTRGRGVDLTEPTQPTRSQCCSN
Protein: Splicing factor 3b, subunit 1 (A0A8I6AP19)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
IFYIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAKGSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPVLTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL
Protein: Spc105-related, isoform B (M9PIC9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Centromeric protein-C, isoform A
- Monopolar spindle 1, isoform B
- Nnf1a
- Serine/threonine-protein kinase polo
- Kinetochore protein NDC80
- Nnf1b
- Small ubiquitin-related modifier
- Bub1 kinase, isoform A
- Bub1-related kinase
- Dorsal interacting protein 4
Sequence:
MNANKRRSSLRKVPTKEDEATTTTSAIKQQIKRRISFSGKKSVREFVNTKETNNWDDSYEVSEHHAEDSSGSKCCSTGSASVARVSEHADKENIPLPSHCEREHVDLSVNLQASVDFTLLPCEMMDKSRKTSSISAVSFCMTSEERKLLQSSLSDRQLVDKTMDLISGSLVNRHQIASSVCEESSIKVATNKLEKVVFTPAVKAVSDSFMDITPLGFTDPNPAAPAPAPVATLYPPTQQSLMELEEDSIVREMRESTKNQTKTPAQKSLFMDVGETKNKTQQGAGGASFSLNVSNNRDRSPSNSFESLNSTMNFTRDESMLIPFDMISGKNISKKLNFRQLNEDLETGKIQIFPNGPKTPTTDRKAKKNRFWCGLEEESAGDNSPKKDIRSIVPRGMLNFSENMTLTPTKTSPVGKNKEKLKAADEKQKYRLSQADEMMLDNTNFLAHARLGDETQSRNTSKNSTRRETTCETSELNLEYPTLSQDFQPIPSSKTRKTDFMAEEMQLSQTNYPAIPALKTATSRRTLHLNESMDHETTKSTYVRKEISVTTQETIYEKSTTNEQNSNQNRNTWACTKTKRRATLLMQESMEEDIISPLKNLQLKPNAAPMNTGQSKVNHTLYLAEPLEEVDINQSNMLPTKNVAPREQLKARKTLLLEEPMEEEMSSNIGYNSKRKTLHLAEPLVVEGEDFILEKHIPIKVVAHQENKSKGRQTLLFEEPVEEEIFHNAKDLPECALKGNKTGPQKYSQLNQGKSFTSQSRSKARQTLLIEEPMEEDTEFNNKYNIAKPGENHIRKIAKSRQTLLLSEPLEEEMCLPPPKNKSIVSQKTIDKSTEQQRSKSRHTLLLSEPIEEEHIQQDLPAEKEDSLARQQRFKPRQTLIMAEPIEEDVGETERRVQTNITGSSTSRPRHTLLMSEPIEEELTNEDKSTNASTNRTLRSRRTILMAEPIEEEGNKSIAEKIGQFTKESSEEAVFQTSKSRQTLLMAEPIEEDVFNQSNDQPKPLPISKDKITRKTSRRHTLITAEPIEEDLSVRKPLENSKESSLTARIIQSFAEPIENALFSITDQIAKQQFSESVQTPPKEPLNYLHQKPRNTLISHETIQEDLEPVNENSSVGPLRSRYRKTLIMAEPIEEDVNNHNMTKQNGICDSLNVPQSGGYMAAKTRQSVHIPVPIEEDHIPGQQQRESEPAVKGRTTLLTESIEEDVPAQHTRISKNKSMGSKVSAEPIIEDLDSNRPEISQSVEETLPQRSQVPDVPSSRRHTLLLSEPMEEDEGIFGHNYPIRTKHQISEKLEKPEGPIHSSKNSVENEEIGTPPSAKTQQSIAMSESMDFQSPQFRPRGPDFNAITPGMSLTEFVDQEEMCKTPIHKRVLLTSHRKKLSMYQPVPIDLEANASGFGTPKNLVQLKRLPTHLTPNLPESKKRNTHLFPNSNMDIELEEDQEGSWGTKSIQMHTGTSKSRRTYTVDQLDASVQPVRDYNPVVTEMNKQGGLNMLELPRKSTYNMDLEEKPITISDVNNYFHEQKEQQRQSSERESGSSNDRTFKSYAATISKFINLTGNTTIFAAAEDLGGEGKDQPHQIDNEHLSLVSTLAEETDDDGDEKEEEEEQKQKQHLLQPEICEAQLNSMVKAGSEGSCKKCRNCNHTLSETRLSSESFVLPPRKLWDFSRLQQRLRNIRQRPSWKEVNTYWEIEEEARLSRNQDSDDSMEQTRVEEEATKWNKAALLEMCKLRTEEKDIAMPPESFFTRLKRLLTEQQPNWIFDYQRKVSQQMIFYNRQLTTIRIVVNYQIEDLVEESTISVCSIQLDNDVPTPKDQWSSREHFLNFHLSLRLPMNPSDEIEGSDETAFLKFLNGIDRRIAEVKQKLHKVLDLLAQKRARLTREANRTIVRKIVRKCIDQEPIVRLEKITFLIEIGNIEDVSFTDILRPELHLFNENIQYLPKGIPFLEAFLTDPEQYLRK
Protein: Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) (Q63447)
Organism: Rattus norvegicus (Rat)
Function: Receptor for neuropeptide Y and peptide YY.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8643536}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peptide YY
- Pancreatic polypeptide prohormone
- Pro-neuropeptide Y
Sequence:
MNTSHLMASLSPAFLQGKNGTNPLDSLYNLSDGCQDSADLLAFIITTYSVETVLGVLGNLCLIFVTTRQKEKSNVTNLLIANLAFSDFLMCLICQPLTVTYTIMDYWIFGEVLCKMLTFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVVIWFISCFLSLPFLANSILNDLFHYNHSKVVEFLEDKVVCFVSWSSDHHRLIYTTFLLLFQYCVPLAFILVCYMRIYQRLQRQRRAFHTHTCSSRVGQMKRINGMLMAMVTAFAVLWLPLHVFNTLEDWYQEAIPACHGNLIFLMCHLFAMASTCVNPFIYGFLNINFKKDIKALVLTCRCRPPQGEPEPLPLSTVHTDLSKGSMRMGSKSNVM
Protein: Cadherin-13 (Q8R490)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- 30 kDa adipocyte complement-related protein
- Adiponectin receptor 2
- Adiponectin receptor 1
- Catenin beta-1
- Catenin alpha-2
- Catenin alpha-2
- Catenin delta 1
- Catenin alpha-1
- Cadherin-8
- Cadherin 9
Sequence:
MQPRTPLTLCVLLSQVLLVTSAGDLDCTPGFQQKVLHIHQPAEFIEDQPVLNLTFSDCKGNKKLHYEVSSPYFKVNSDGTLVAVRNITAVGRTLFVHARTPHAEDMAELVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPEGSKFRLTGKGVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLFVETTDASGRTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIVIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPATGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTKQENISVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLSINPINGTVDTTAVLDRESPFVHNSVYTALFLAIDSGNPPATGTGTLMITLEDVNDNAPVIYPTVAEVCDDARNLSVVILGASDKDLHPNTDPFKFEIHKQTVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCKNSKVDCNAAGTLHLSLSLLLLFSLLSLLSGL
Protein: LAS seventeen-binding protein 1 (LAS17-binding protein 1) (P53281)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in resistance to EDTA.
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, actin patch.
Interaction partners:
- [PSI+] inducibility protein 3
- Proline-rich protein LAS17
- Myosin tail region-interacting protein MTI1
- Protein BZZ1
- E3 ubiquitin-protein ligase RSP5
- Myosin-3
Sequence:
MSASLVNRSLKNIRNELEFLKESNVISGDIFELINSKLPEKWDGNQRSPQNADTEEYVEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGKSNNKIGIFPANYVKPAFTRSASPKSAEAASSSTVSRPSVPPPSYEPAASQYPSQQVSAPYAPPAGYMQAPPPQQQQAPLPYPPPFTNYYQQPQQQYAPPSQQAPVEAQPQQSSGASSAFKSFGSKLGNAAIFGAGSAIGSDIVNSIF
Protein: Uncharacterized membrane protein YNR062C (P53748)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Putative uncharacterized protein YCL021W
- Uncharacterized transcriptional regulatory protein YNR063W
- Probable alpha-1,3-mannosyltransferase MNT4
- Anaphase-promoting complex subunit 1
Sequence:
MSIAQDRGIVFKLLSIYRAAAGIFMALAQLIVIFFGYCDFKIKGYRIASYNAPTFASSFIILAVCLLLVVVLENPEVKVTNSENSLFSALKQFFRVERKKLISCLILLWSMFLSSFIMSEVVYFMPLFLTLHVNWDTKFQGIAFMVASILGVTGSYFAPKLINVGCSCGRAKDGGLEESDTTGSETVEVKKKDSLYSGQVFLSIFALFVSLLGQAFMIGASEALKHKSMPPTNSGIFFSAGMSITLLGYNFLASSIPALFSMYIDPKLKVQLMPSIGAISGIGKLVAPIVLAALYGTRLGLSIAVGFGMILVAVSIPPLIWLRKKRC
Protein: Tetratricopeptide repeat protein 29 (TPR repeat protein 29) (Q80VM3)
Organism: Mus musculus (Mouse)
Function: Axonemal protein which is implicated in axonemal and/or peri-axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility.
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:31735292, ECO:0000269|PubMed:31735294}.
Interaction partners:
- Dynein axonemal heavy chain 1
- Cilia- and flagella-associated protein 43
- Tetratricopeptide repeat protein 21A
- Cilia- and flagella-associated protein 65
- Cilia- and flagella-associated protein 91
- Cilia- and flagella-associated protein 70
- Dynein axonemal heavy chain 17
- Cilia and flagella-associated protein 47
- Cilia- and flagella-associated protein 44
- Fibrous sheath-interacting protein 2
Sequence:
MATFPPLPMTHTRLAILARQKLPCSSKKIPRAQLIKEKEDIDYYLEQNFKGLSKEEVAAHRNSYKKSICVDMLRDGFHKSFTELFALMEQWDKLPEAAKAQSLFWQQRPLEDQPDKLDNFYHYLTRAEAAERKGYYEEVYNNLYALACYFDNSEDKWVRNHFYERCFNIAQLIKADGGKKEAEAESHMGLLFEEEGELLKAAEHYEAFHELTHGRLWKDGTGQLLNLVACESLVRTYRLLSDRMLENKDYKQAIKILIKASEIAREGNDRSMEGEASYYLGLAHLASGEYETALTVLNRYSEISTSLDDDHGLGRAYEAIAKALQSQGETTEAINYLEKFVTIARNNLQSLDMIRACTMLGDIYNEKGQYSKASEYFQQAFSTAMELMKTALMDETKVHYGIARAHQMMLAMKGYIESADSNGLNCLLSWKETRTQIEYDPILGESRRATEDNIYQLPDAEEETRRSPENQ
Protein: Swi1-interacting protein swi3 (Replication fork protection complex subunit swi3) (O14350)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Forms a fork protection complex (FPC) with swi1. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. It is required for programmed fork-pausing which is necessary for mating-type switching. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors. It is involved in termination at the mat1-proximal polar-terminator of replication (RTS1) and also required for activation of the Rad53-like checkpoint kinase cds1.
Subcellular location: Nucleus {ECO:0000269|PubMed:15367656}. Note=Nuclear throughout the cell cycle. Associated with chromatin during S phase.
Interaction partners:
- Mating-type switching protein swi1
- Mediator of replication checkpoint protein 1
- DNA replication licensing factor mcm2
- DNA replication complex GINS protein sld5
- DNA replication licensing factor mcm7
- Minichromosome loss protein 1
- DNA replication licensing factor mcm4
- Cell division control protein 45 homolog
- Replication factor A protein 1
- DNA replication complex GINS protein psf1
Sequence:
MSTAASDSGVEKLVEENKREEVKKNEEEKEFDLGLEENPDSVKKPRKRLAKFDEERLISENGIPKLRKMMRKVKLKGKGHEAKDLKQLLGMYHIWTHELYPRATFDDSISYLKTLGKHRSVKVRRRGWINEIAVENGSDSNASLFTGPSSNSLVNLTSGDPYVQDTADDAFVAQDNDTQLE
Protein: R2D2 (Q2Q0K8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDNKSAVSALQEFCARTQINLPTYSFIPGEDGGYVCKVELLEIEAIGNGRSKRDAKHLAASNILRKIQLLPGIHGLMKDSTVGDLGEELTNLNRDMVKELRDYCVRREMPLPCIEVVQQSGTPSAPEFVACCSVASIVRYGKSDKKKDARQRAAIEMLALISSNSDNLRPDQMQVASTSKLKVVDMEESMEELEASRRKKFTTYWELKEAGSVDHTGMRLCDRHNYFKNFYPTLKKEAIEAINSDEYESSKDKAMDVMSSLKITPKISEVESSSLVPLLSVELNCAFDVVLMAKETDIYDHIIDYFRTMLI
Protein: GDNF family receptor alpha-2 (GDNF receptor alpha-2) (GDNFR-alpha-2) (GFR-alpha-2) (GDNF receptor beta) (GDNFR-beta) (Neurturin receptor alpha) (NRTNR-alpha) (NTNR-alpha) (RET ligand 2) (TGF-beta-related neurotrophic factor receptor 2) (O00451)
Organism: Homo sapiens (Human)
Function: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O08842}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:O08842}.
Interaction partners:
- Neurturin
- Glial cell line-derived neurotrophic factor
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Persephin
- Artemin
- High affinity nerve growth factor receptor
- Neural cell adhesion molecule 1
Sequence:
MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
Protein: Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1) (Q9JHZ9)
Organism: Rattus norvegicus (Rat)
Function: Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity. Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons. Also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine. The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+), pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions. Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport. In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:10619430, ECO:0000269|PubMed:17148440, ECO:0000269|PubMed:19596860, ECO:0000269|PubMed:21525297, ECO:0000269|PubMed:29561757}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15716335}. Note=The localization appears to be basolateral in the plasma membrane of hepatocytes surrounding the central vein. Localized at the cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelial cells. In astrocytes, the localization at cell membrane is decreased by ammonia through the PKC signaling. Expressed in both luminal and abluminal plasma membranes of larger microvessels and blood brain barrier (BBB) capillaries (By similarity). Restricted to the basolateral membranes of S3 segment cells of the proximal tubules (PubMed:15716335). {ECO:0000250|UniProtKB:Q9DCP2, ECO:0000269|PubMed:15716335}.
Interaction partners:
- Sodium-coupled neutral amino acid transporter 5
- Neutral amino acid transporter B
Sequence:
MEIPRQTEMVELVPNGKHLEGLLPVGMPTADTQRAEDAQHCGEGKGFLQQSSSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKSSGIVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEKPTPVWYMDGNYLVILVSVIIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFQVPCPLAHNLVNATGNFSHMVVVEEKSQLQSEPDTAEAFCTPSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKRKMQHISNLSIAVMYVMYFLAALFGYLTFYDGVESELLHTYSKVDPFDVLILCVRVAVLIAVTLTVPIVLFPVRRAIQQMLFQNQEFSWLRHVLIATGLLTCINLLVIFAPNILGIFGIIGATSAPCLIFIFPAIFYFRIMPTEKEPVRSTPKILALCFAAVGFLLMTMSLSFIITDWVSGTSQHGGNH
Protein: Zinc finger protein weckle (Q9VJN5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as an adapter to assemble/stabilize a Toll/wek/Myd88/tube complex; required for efficient recruitment of Myd88 to Toll. Dispensable for innate immune response; plays a minimal role, if any, in the immune defense against Gram-positive bacteria and fungi. Involved in dorsoventral axis determination.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16782008}. Note=Localizes to the plasma membrane in embryos when bound to Myd88. {ECO:0000269|PubMed:16782008}.
Interaction partners:
- LD20892p
Sequence:
MGVPTSDWIYWCRLCARDDVVYKVRERDDDLVRIISKCFDVEMTLEEPELGSMLCEECYSVIGQLITFSDSVSKVQAIFELLRHSEPQDSQDLDALRLEYGLPPACKQDLEFLDIDDTEDRCSLVEELTISDHSTSPSPDFEAQTVRTRANLKQCNSDPKVLASPTASIPEVETKRSRRQQFAAKRNSKVYTATESDDEEAILDEDEAVSPPPLKRKRGRPKGSGKQKNVDDSDNVTSREPDDNAKSKQDDKTSELSMSPHGSQSSNFVDYPCKICNETFMSFMALRRHKHDMHGGPKKYVCDHCGKGLKTFTSLVEHQLVHTEEKPCICPVCNAGFKNKARLRVHSQTHGEPKFECNVCGKKLQTRAILNKHKYVHTDERRFKCEVCGSGCKNSTALKIHLLGHTGLRPYVCKYCGKAFASNTNCRSHKWKKHPELASKEDETESSRVPVPTLEELRAITREMAKAKQD