wanglab/gogpt-training-data huggingface dataset:
Protein: Glycerol kinase, glycosomal (GK) (Glycerokinase) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) (Q9NJP9)
Organism: Trypanosoma brucei brucei
Function: Catalyzes the phosphorylation of glycerol using ATP. Under anoxic conditions, when glycerol 3-phosphate accumulates in the glycosome, it catalyzes the reverse reaction, maintaining the ATP balance. Key enzyme for the survival of bloodstream forms under anoxic conditions.
Subcellular location: Glycosome {ECO:0000269|PubMed:11154065}.
Interaction partners:
Sequence:
MKYVGSIDQGTTSTRFIIFDERQRPVSVHQVPHTQHTPHPGWLEHDPMEIFRSACKCMSVAIAKLRQKDASFRKIEAIGITNQRETTVAWDRVTKEPLCYAPVWNDLRTYDITKKVTAELGGGDSMFASKITGLPVSTYFAAFKMRWMLENVPAVADACRRGTLCFGTIDTWLMYKLSGGKAFVTDVTNASRTFLMDLRTRKWSPELCEKLKIPMETLPEIRSNSELFGYVETDECGVAAALNERTPIMGSIGDQQSALFGNMCFEKGEAKNTYGTGCFLLMNVGEEARFSKHGLLSTVGFQVGRDGPCYYALEGAIACAGATVEWMRRNMNLFSHITECEKLARSVPGTQGIVFVPAFSGLLAPYWDPSARGTIVGMTLKTTRAHVIRAALQAIALQLNDVVGSMKRDAGLNLSSLRVDGGLSKNGLLMEIQASLLGVDILVPSMHETTALGAALCAGLAAGVWTSLEEVKAVSRRENSWKTVSPSGSAMEREAMIAEWREALKRTKWAKL
Protein: Vang-like protein 2 (Loop-tail protein 1) (Loop-tail-associated protein) (Van Gogh-like protein 2) (Q91ZD4)
Organism: Mus musculus (Mouse)
Function: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23029439}; Multi-pass membrane protein {ECO:0000269|PubMed:23029439}.
Interaction partners:
- Prickle-like protein 1
- Prickle planar cell polarity protein 3
- Prickle-like protein 2
- Predicted gene 21981
- Segment polarity protein dishevelled homolog DVL-2
- Segment polarity protein dishevelled homolog DVL-1
- Protein scribble homolog
- Segment polarity protein dishevelled homolog DVL-3
- Protein Wnt-5a
- Frizzled-3
Sequence:
MDTESQYSGYSYKSGHSRSSRKHRDRRDRHRSKSRDGSRGDKSVTIQAPGEPLLDNESTRGDERDDNWGETTTVVTGTSEHSISHDDLTRIAKDMEDSVPLDCSRHLGVAAGAILALLSFLTPLAFLLLPPLLWREELEPCGTACEGLFISVAFKLLILLLGSWALFFRRPKASLPRVFVLRALLMVLVFLLVISYWLFYGVRILDARERSYQGVVQFAVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDGASRFYNVGHLSIQRVAVWILEKYYHDFPVYNPALLNLPKSVLAKKVSGFKVYSLGEENSTNNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEEQKNPREVMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGPTIQYHKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKSHKFVMRLQSETSV
Protein: Barrier-to-autointegration factor 1 (Q03565)
Organism: Caenorhabditis elegans
Function: DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2. In association with lem-3, plays a role in radiation-induced DNA damage repair response.
Subcellular location: Nucleus {ECO:0000269|PubMed:17170708}.
Interaction partners:
- Serine/threonine-protein kinase VRK1
- Ankyrin repeat and LEM domain-containing protein 2 homolog
- Lamin-1
- LEM protein 2
- Emerin homolog 1
- Charged multivesicular body protein 7
- Sun domain-containing protein 1
- Transmembrane protein 201 homolog
- Putative aminopeptidase W07G4.4
- Protein mel-28
Sequence:
MSTSVKHREFVGEPMGDKEVTCIAGIGPTYGTKLTDAGFDKAYVLFGQYLLLKKDEDLFIEWLKETAGVTANHAKTAFNCLNEWADQFM
Protein: Cytochrome P450 72A68 (EC 1.14.14.-) (Q2MJ19)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Catalyzes the carboxylation of oleanolic acid at the C-23 position to form gypsogenic acid. Involved in the hemolytic saponin biosynthetic pathway.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MELSWETKSAIILITVTFGLVYAWRVLNWMWLKPKKIEKLLREQGLQGNPYRLLLGDAKDYFVMQKKVQSKPMNLSDDIAPRVAPYIHHAVQTHGKKSFIWFGMKPWVILNEPEQIREVFNKMSEFPKVQYKFMKLITRGLVKLEGEKWSKHRRIINPAFHMEKLKIMTPTFLKSCNDLISNWEKMLSSNGSCEMDVWPSLQSLTSDVIARSSFGSSYEEGRKVFQLQIEQGELIMKNLMKSLIPLWRFLPTADHRKINENEKQIETTLKNIINKREKAIKAGEATENDLLGLLLESNHREIKEHGNVKNMGLSLEEVVGECRLFHVAGQETTSDLLVWTMVLLSRYPDWQERARKEVLEIFGNEKPDFDGLNKLKIMAMILYEVLRLYPPVTGVARKVENDIKLGDLTLYAGMEVYMPIVLIHHDCELWGDDAKIFNPERFSGGISKATNGRFSYFPFGAGPRICIGQNFSLLEAKMAMALILKNFSFELSQTYAHAPSVVLSVQPQHGAHVILRKIKT
Protein: Chloride intracellular channel protein (Q6FIC5)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00037855}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037855}. Membrane {ECO:0000256|RuleBase:RU362009}; Single-pass membrane protein {ECO:0000256|RuleBase:RU362009}. Cytoplasm {ECO:0000256|RuleBase:RU362009}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK
Protein: Cilia- and flagella-associated protein 45 (A0A087WUV1)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium, flagellum {ECO:0000256|ARBA:ARBA00004230}.
Interaction partners:
Sequence:
MVRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEK
Protein: PA-I galactophilic lectin (PA-IL) (Galactose-binding lectin) (Q05097)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
Subcellular location: Cytoplasm. Periplasm. Cell surface. Note=Low exposure on the cell surface.
Interaction partners:
- Fucose-binding lectin PA-IIL
- Protease LasA
- Elastase
- HTH-type quorum-sensing regulator RhlR
- Transcriptional activator protein LasR
- ATP-dependent RNA helicase RhlB
- Acyl-homoserine-lactone synthase
- High-affinity zinc uptake system protein ZnuA
- chitinase
- Multiple virulence factor regulator MvfR
Sequence:
MAWKGEVLANNEAGQVTSIIYNPGDVITIVAAGWASYGPTQKWGPQGDREHPDQGLICHDAFCGALVMKIGNSGTIPVNTGLFRWVAPNNVQGAITLIYNDVPGTYGNNSGSFSVNIGKDQS
Protein: Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204) (P21757)
Organism: Homo sapiens (Human)
Function: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- Apolipoprotein E
- Collagen alpha-2
- Platelet glycoprotein 4
- Scavenger receptor class B member 1
- Lysosome membrane protein 2
- Macrophage mannose receptor 1
- Macrosialin
- Oxidized low-density lipoprotein receptor 1
- Toll-like receptor 2
- Zinc phosphodiesterase ELAC protein 2
Sequence:
MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL
Protein: Cell division control protein 25 (P43069)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.
Interaction partners:
- Ras-like protein 1
- Pin3p
- Adenylate cyclase
- Ras GTPase activating protein
- Ras2p
- Guanine nucleotide-binding protein subunit alpha
- M-phase inducer phosphatase
Sequence:
MSSANYISDEVPPDMVSPHDHRPSKDEPLKHLDTVIALYDFPGTQSSHLPLNLGDTIHVLSKSATGWWDGVVMGNSGELQRGWFPHNYVRSVNYVQPVLKKLKDNKDLDSITAANTAANVVMPSLTNLIQKSLQESERNSPANSTRKNSVVSFASSETSMPSDSKYTQQQTNTNQNSPEYQSISLPSTRDHSTVEMQLPSQQSSISHTLTGFGIGDDEIIPMEVEEAEKLVEEYRLKYNKTVTWIPRTSTKGDIIFYCEQLDVYCESLPLILFDGEASSPNLEYPGSDVIMDPTPISVQGSQSMENVLDTREGSAAGSFDSTKRDSNVSMSTQSSGSSYHRFSRPFFSVDNLFYKHSSDIGTWNELKEQCNYILDLMLKAIKDQNRQFFSTHFSRLNKLVVALCAAVRLNQEDYIDTKYENTTRRKLKRVCASFAQIYINGILHLSVLHYSLEGFNEGRLFGYDMGKLNRSSSSSAFQSPASSLSTIRQGSDDSTRFAQKLSQDRNSEGNGDMNYINQLVYEIDNLRENVNSIVKIFLKLSANKKIKNSDYDSSDASDDEGEDRFDILPQVYPRFLVDEFNGGNWCNPFFSTKNTVLNVSGDDLKNRYHTKIIIDHSAYDSLSQYVDKIVDACENILEALDPKVQNTFYYNEMLRNERNTQILRLTYKSLYHCSAMVDLIESFDFTVFCSVKRHTGNAIDTEDESYENPSVWGDHYDSNLSFDYPVVLEFFRLKQELHDLVAKIIMATQSLTLEDPEVFKGLKEEDPLFYNREISKIPKEKAALLLSSILKEQLSFKDGGAISLNPDTLLSGYLVEIAKTTKTVLLITQQLIEERETIINYATRVMQDNFDVQLLLVERNNTSSSEKADDNSYYVGGHKKSTDVPWYLEGDDEYELLLDVKGNIKGGSKEALVSHLTHHLSLDSNFNAVFLLMFSSMMSLGELISLLIARFNIEPPEGLSYEEYNLWVSKKRNPIRLRVINIMKLLLEKNWSMSYYNEPVLRRWLTFAHSDQVQTYSLGNLLVNYLERLLRGERIYVERDPVIPNTKPPAPLTKGSSLSKKPRVMDIDYVELARQLTLREFKLYCKITKFACLAKVWGKKSGLSESIDSITQFIKASNQLTNFVGYMILRKADPKKRVQIIRYFIQVADKCRQYNNFSSMTAIISALYSSPIHRLKKTWEYMNADALSNLKNMNKLMNSSRNFNEYRDVLKFIGSEPCVPFFGVYLSDLTFVYHGNPDYLYNRTRQVNFAKRAKTSEIVSGIDRFKTTGYNFQEVPEIQKFLDAWFEKCPTIDEQYQISLNLEPREQAVGASNSNSTTNATTNIKSFKPFSLK
Protein: Cysteine/Histidine-rich C1 domain family protein (F4HZZ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Early light-induced protein 2
Sequence:
MGFEDGPRCLMSHPAHPSHNLSVRYRFNFRIGCFTCGGKAAATTPDCLYYYCTTCEVTFHNGCHQRPRRITHPYHLQHPLTLFYRNPETRVISNIIPDACPGKIEDTSGPEKYEFVDIVPYKSDIIFNKCTWCAKDFKGDWFYRCLICSFCLDLSCAATLPLLTITNPKSHHHSLVFLPRPLLVPCDACGLVDGLEPSYACFQCNYMVHQNCIDLPRVIKITRHPHRLSHTPYCSSLTSSCQICYKEVDIKYGQYSCHLQDCFYVVHSKCATHENVWDGKELEWEIESDETEDISPFRNLGDGFIKHFCHKHRLKLKNHDGARDTEKQCRACIYPIVSHQFYHCKKCNYSLHEVCAGLSRKLDHALHNHTLILSPSPGKFCCSACSRESTGFSYICSNKGCQDFVLDVRCISVLEYFIHRSHEHPIFISTSYNSKDEILCKVCKKRCLGAHLQCTLCEFTMCYSCAIIPDEIHYKFDKHPLTLSCGESADNTYWCEVCEKQLDPKEWFYTCNKCCITIHLHCIFGSSVFMKPGSIFRDYYGKVQVFRNNSNTRQLCYMCHNRCTGLIFYEGYRRNATYYYNHSNRSTHRMIFCSLECEILGMRKRRLIRLPR
Protein: 8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (MutT homolog 3) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18) (Q6ZVK8)
Organism: Homo sapiens (Human)
Function: Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
Interaction partners:
- Nucleotide triphosphate diphosphatase NUDT15
- ADP-sugar pyrophosphatase
- Oxidized purine nucleoside triphosphate hydrolase
- Uridine diphosphate glucose pyrophosphatase NUDT14
- m7GpppN-mRNA hydrolase NUDT17
- Uridine diphosphate glucose pyrophosphatase NUDT22
- NAD-capped RNA hydrolase NUDT12
Sequence:
MASEGLAGALASVLAGQGSSVHSCDSAPAGEPPAPVRLRKNVCYVVLAVFLSEQDEVLLIQEAKRECRGSWYLPAGRMEPGETIVEALQREVKEEAGLHCEPETLLSVEERGPSWVRFVFLARPTGGILKTSKEADAESLQAAWYPRTSLPTPLRAHDILHLVELAAQYRQQARHPLILPQELPCDLVCQRLVATFTSAQTVWVLVGTVGMPHLPVTACGLDPMEQRGGMKMAVLRLLQECLTLHHLVVEIKGLLGLQHLGRDHSDGICLNVLVTVAFRSPGIQDEPPKVRGENFSWWKVMEEDLQSQLLQRLQGSSVVPVNR
Protein: Misfire, isoform B (B7Z0F0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MARTQDEWPELVLSLSASGKDVGVCRLNAKLFLNLRNQDADQDQETLCWRLKSFSFKSAGCSHTCPNCGCTTAIVSGCLSIVVERERKRFLAVVNKEWANIEPMLWQLNPEQTHFLCHVYIHQAKVRPGGEKKNICDSHLRVLFADQACETYTSPGTLSPIWNAVITFNWVSLPGGIGLYLKNPPLLSLEFYNSERSLPEDLVGMGSVAMSVISEDRASDSNWEDAGVFGCSKNPLRKLQRLKYLTPPPLKWVPIARKGTLQAEVLMSAEIIQISMESLTTGQNDKKEPQLATGIPMAIRPTMQNFVLEVFFVGLRNYSKSSMSSAGKRKINLMMGDLVLSSGPSTARIRNSINFLVAYASGVVSLPDQQDYWPAIIATDVLLSGFSSESILGAALIPNSSNFLQRDRTLKCVFKKEQEAAEASTTVSVDEDDEDEEEELEWEEEETKPSRISSWWMRLLFAFGLRPAPYANRHALRFHDDLDDHELVEEREFTWWTKFYNSMYWSAAEMCHEHKHRLVIYYEELEKQAQFGYLQDWAVPVQLVHGVKFKKHGPPKEDIYATLKLQLKLTPCQCPVLEDPGGGGDMVRNMSNPIHPRHQSTLQSLGETVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKIKDEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYYYGNVIEVDGMLFGDETLISKDEELQERLSLAVLKNMDKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPSPIDITPVPPADFEVRVVVKNLVGIQAGDKNIFGKLMSDVYVIGWCEDEDKRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMVIRRKAGLLEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKRKRINLFKRKVINGWFPLQSNAHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPP
Protein: A-to-I RNA editing regulator adr-1 (Q9U3D6)
Organism: Caenorhabditis elegans
Function: Required for the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. Does not have deaminase activity but binds to dsRNA and regulates A-to-I RNA editing, possibly by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 for target adenosines. Regulates editing efficiency of specific adenosines in 3' untranslated regions of target mRNAs. Represses editing efficiency of the Y75B8A.8 3' UTR in neurons. Required for correct expression and A-to-I editing of clec-41. Required for normal chemotaxis. Also required for normal vulva development. Plays a role in determining lifespan. Not required for RNA interference. Likely to play a role in determining whether a dsRNA enters the RNAi pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:18719245}. Cytoplasm {ECO:0000269|PubMed:18719245}. Note=Detected both in the nuclear fraction and in the ribosome-containing pellet of the cytoplasm. {ECO:0000269|PubMed:18719245}.
Interaction partners:
- DRBM domain-containing protein
- Protein kinase domain-containing protein
- Adr-2-binding protein 1
- Cubilin
- adenosine deaminase
- Double-stranded RNA-specific adenosine deaminase adr-2
- CABIT domain-containing protein
- Piwi domain-containing protein
Sequence:
MDQNPNYNFGYGQAYGSGTDHTSDSTNNYNWASQWSQPESAASLATHTFPQYVSQQQQQQQQQAQQQAQNTYAAMNPISTFMQQQQRAQTFPQKKYGQQGGAPKPSAIRNNNFGAFGGGHALSQEWVQPMSQNQMGGPQGNRFFNNQKGGPFNQNKPNWRQNKPKGPAAPKKFDSTGKSPAMLLHELFKDVSEEYTEVEGVPKKYCCTLKVNGRTFQMESVNKKAAKQKCSELVVRDLRPDVHVTPFEEGVAAKAAAPVKKEIDAASGNGQNNKRNLLQADAISNQPTPKKVSAVKKAKLQLTPVESALSLLDLMQKIIAESAEKYSPVFEASEVPKDPEIPEVEVKKEEVDTNGENVANEKKSGWRKNETMHNVTLKFVEQNKQYTKMGPSRGVLKDMVIREALRDLFNVSHADITTVARRHASNRLGHDTTILQCLNTICSILNCTLTIECEPAEDRPLGIGRAYFMAKCTIIDHNENDLKFEVKSSSLASKAMAKDWVAQETLKNYFAIDPSSCVKTDAVSSQGPCALLHAMLNKQTKQKCKIAYEFKDNVPPVAGQATTTFYCECVIDETDRYIGVGRSKKLAKSEAAMQALKKLFKIDYDPAGNYPLALTSRAMTESKVSPLCRHIAEFCKREYHQMTEYYQIPPSNLFAAFLLVNAQEEKRVLAMGSSIQYIVEPDTLSGANGTSLLHLDAIILARRAMLKAFIHELSTVDSECSIFEKKEEGKAALKPNLRLVLYSNYSPPCIHAVDDAATKKLSYVTPTNLTCVPDDVLTYEQIKETKSLRVHCTADKLFKWNTLGIQGALLSNVLHPIFIDNIFFGSEAPVSDESLSYALQGRLGPNENEREIIVESMPVQMRMHMGISHLWHRGVDSVETLDYNTGRTSKGSPSRVCKAEIFEAYRKLNGVDQAVVNYAKAKEMASEYQYEKKVFYEKLEAAGLGKWQTKPAELVDSFTLAAFD
Protein: Protein UL20 (P10204)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: Plays an essential role in egress of virus particles from the nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a functional protein complex with gK and this interaction is absolutely essential for their coordinate intracellular transport, gK glycosylation, expression on host cell surface, and function. Together, they modulate gB-mediated virus-induced cell fusion and virion egress and therefore actively participate in these processes.
Subcellular location: Virion {ECO:0000269|PubMed:18596102, ECO:0000269|PubMed:7933124}. Host Golgi apparatus membrane {ECO:0000269|PubMed:15254173}; Multi-pass membrane protein {ECO:0000255}. Host nucleus membrane {ECO:0000269|PubMed:15254173}; Multi-pass membrane protein {ECO:0000255}. Note=During virion morphogenesis, this protein probably accumulates in the trans-Golgi where secondary envelopment occurs. It is probably transported with gK to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). {ECO:0000269|PubMed:15254173}.
Interaction partners:
Sequence:
MTMRDDLPLVDRDLVDEAAFGGEEGELPLEEQFSLSSYGTSDFFVSSAYSRLPPHTQPVFSKRVILFLWSFLVLKPLEMVAAGMYYGLTGRVVAPACILAAIVGYYVTWAVRALLLYVNIKRDRLPLSAPVFWGMSVFLGGTALCALFAAAHETFSPDGLFHFIATNQMLPPTDPLRTRALGIACAAGASMWVAAADSFAASANFFLARFWTRAILNAPVAF
Protein: Pre-rRNA-processing protein TSR2 homolog (Q969E8)
Organism: Homo sapiens (Human)
Function: May be involved in 20S pre-rRNA processing.
Interaction partners:
- Small ribosomal subunit protein eS26
- Pre-rRNA-processing protein TSR1 homolog
- 18S rRNA aminocarboxypropyltransferase
- Ribosome production factor 2 homolog
- Glutamate-rich WD repeat-containing protein 1
- Neuroguidin
- RNA-binding protein NOB1
- U3 small nucleolar ribonucleoprotein protein IMP4
- Probable ribosome biogenesis protein RLP24
- Protein LTV1 homolog
Sequence:
MAGAAEDARALFRAGVCAALEAWPALQIAVENGFGGVHSQEKAKWLGGAVEDYFMRNADLELDEVEDFLGELLTNEFDTVVEDGSLPQVSQQLQTMFHHFQRGDGAALREMASCITQRKCKVTATALKTARETDEDEDDVDSVEEMEVTATNDGAATDGVCPQPEPSDPDAQTIKEEDIVEDGWTIVRRKK
Protein: Signal recognition particle subunit SRP19 (Q8I5P4)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Small ribosomal subunit protein eS30
- Signal recognition particle 14 kDa protein
- Signal recognition particle subunit SRP9
- Signal recognition particle 54 kDa protein
- Signal recognition particle subunit SRP68
- Signal recognition particle subunit SRP72, putative
- Signal recognition particle receptor subunit alpha, putative
- Signal recognition particle receptor subunit beta
- 60S ribosomal protein L23
- 60S ribosomal protein L19
Sequence:
MVKEQGLNITNVYNRDIYNNAENNTIDESKDYSRWKIIYPNYLNKKKKVNEGRRINLKYCVSDPTVDEIALACKELNVSYVIEKKKYYPRDWLIEGRIRIKLPNQNNDILNKFELMKKIGLKLQTIKVNVESNVVINTNNLSKKKKKKKNKE
Protein: RNA-binding protein 1 (AtRBP1) (Q9C652)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: RNA binding protein. Can also bind in vitro to single-stranded DNA.
Interaction partners:
- AT5g11760/T22P22_150
- F3E22.8 protein
- At2g17975
Sequence:
MDYDRYKLFVGGIAKETSEEALKQYFSRYGAVLEAVVAKEKVTGKPRGFGFVRFANDCDVVKALRDTHFILGKPVDVRKAIRKHELYQQPFSMQFLERKVQQMNGGLREMSSNGVTSRTKKIFVGGLSSNTTEEEFKSYFERFGRTTDVVVMHDGVTNRPRGFGFVTYDSEDSVEVVMQSNFHELSDKRVEVKRAIPKEGIQSNNGNAVNIPPSYSSFQATPYVPEQNGYGMVLQFPPPVFGYHHNVQAVQYPYGYQFTAQVANVSWNNPIMQPTGFYCAPPHPTPPPTNNLGYIQYMNGFDLSGTNISGYNPLAWPVTGDAAGALIHQFVDLKLDVHSQAHQRMNGGNMGIPLQNGTYI
Protein: E3 ubiquitin protein ligase DRIP1 (EC 2.3.2.27) (DREB2A-interacting protein 1) (RING-type E3 ubiquitin transferase DRIP1) (Q9M9Y4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the response to water stress. Mediates ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator DREB2A. Functionally redundant with DRIP2.
Subcellular location: Nucleus {ECO:0000269|PubMed:18552202}.
Interaction partners:
- Putative E3 ubiquitin-protein ligase RING1a
- Dehydration-responsive element-binding protein 2A
- Putative E3 ubiquitin-protein ligase RING1b
- PHD finger protein ALFIN-LIKE 2
- E3 ubiquitin-protein ligase SDIR1
- E3 ubiquitin-protein ligase AIRP1
- E3 ubiquitin-protein ligase RMA1
- E3 ubiquitin-protein ligase KEG
- E3 ubiquitin-protein ligase HOS1
- E3 ubiquitin-protein ligase RHA2A
Sequence:
MMIKVKKETMRACLSCSICDNILRDATTISECLHTFCRKCIYEKITEDEIETCPVCNIDLGSTPLEKLRPDHNLQDLRAKIFALKRRKVKAPGIVSLPGKRKERSISSLVVSTPMVSAQAGTTRRRTKAPTRKELRNGSLAERTVKKEESSGDELLESTSSPDTLNKFTQNKRQSKKSCKESISNKENKDGDEPWDSKMDWKPLNFLVEVANGTKPLKSSASQGSGSKSEHANVSRNQFQGSKTKTKNKKRKCKREDDKSNNGDPTTSETVTPKRMRTTQRKRSATTLGDSRNLPQPDESSAKQERRNGPVWFSLVASNDQEGGTSLPQIPANFLRIRDGNTTVSFIQKYLMRKLDLESENEIEIKCMGEAVIPTLTLYNLVDLWLQKSSNHQRFAALVGSSAKDFTMVLVYARKLPECNM
Protein: Small ribosomal subunit protein eS17 (40S ribosomal protein S17) (P63276)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P08708}.
Interaction partners:
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein eS8
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein uS4
Sequence:
MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGAV
Protein: Kinesin-like protein kif3a (Q2P9S3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
FAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSE
Protein: 23.2 kDa heat shock protein (OsHsp23.2) (Q7XUW5)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Endoplasmic reticulum {ECO:0000305}.
Interaction partners:
- 23.6 kDa heat shock protein, mitochondrial
Sequence:
MASMRTAAAAAMLACIAVVLASTAADGALLPWFGGGGARDEAVPELGLLAAADPFRILEHVPFGFDRDDVAMLSMARVDWRETGDAHEVVVDVPGMRKEDLRVEVEDNRVLRISGERRREETTEQKGGGDHWHREERSYGRFWRQLRLPDNADLDSIAASLDNGVLTVRFRKLAPDQIKGPRVVGIASAGGDDGGKKSIGGAGEGQNQQAKKVEL
Protein: Probable indole-3-acetic acid-amido synthetase GH3.2 (EC 6.3.2.-) (Auxin-responsive GH3-like protein 2) (OsGH3-2) (P0C0M2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May catalyze the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin.
Interaction partners:
Sequence:
MAPAAVAAAEAGSKAAAVAGKAVAACERDAEKLEFIEEMTRGFDAVQERVLAAILARNNGAEYLRRHGMEGRTDREAFKARVPVVTYEDLRPEIERIANGDRSNIISSHPITEFLTSSGTSAGERKLMPTIEDELDRRQMLYSLLMPVMNLYVPGLDKGKGLYFLFIKSETKTPGGLPARPVLTSYYKSDHFKHRPFDPYNVYTSPTAAILCTDAFQSMYAQMLCGLVARAEVLRVGAVFASGLLRAIRFLQLHWRELAHDIRTGTLSAKVTEPSIRDAVAEVLAAPDAELAAFVEAECGKDKWEGIITRMWPNTKYLDVIVTGAMAQYIPTLKFYSGGLPMACTMYASSECYFGLNLRPMCDPSEVSYTIMPNMGYFELMPHDPDAPPLPRDAPPPRLVDLADAEVGREYELVITTYAGLCRYRVGDILQVTGFHNAAPQFRFVRRKNVLLSIDSDKTDEAELQAAVERASALLSPYGASIVEYTSQADATTIPGHYVVYWELMVREGGAWPPPAEEEGRGVFERCCLEMEEALNAVYRQGRNGEAIGPLEIRVVRAGTFEEVMDYAISRGASINQYKAPRCVSFGPIIELLNSRVISKHFSPACPKYSPHKK
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q585I8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Serine/threonine protein kinase, putative
- non-specific serine/threonine protein kinase
Sequence:
MTLVQTLLERMLSAKGSATQQQILIREEDIRTILNTVRDVFMSQPMLLEITPPVRICGDIHGQYYDLLRVFEKCGFPPYSNYLFLGDYVDRGRHSVETITLLFCYKIVYPENFFLLRGNHECASINKMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVVSEKIICMHGGLSPDMTSLASVNEIERPLDVPDKGILCDLLWADPEDEVKGFLESDRGVSYLFGEDIVTDFLDMVDMDLVVRAHQVMERGYGFFANRQLVTIFSAPNYCGEFDNDAAVMNVDEKLQCSFLIIPAR