wanglab/gogpt-training-data huggingface dataset:
Protein: Beta-carotene 3-hydroxylase 2, chloroplastic (AtB2) (EC 1.14.15.24) (Q9LTG0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Nonheme diiron monooxygenase involved in the biosynthesis of xanthophylls. Specific for beta-ring hydroxylations of beta-carotene. Has also a low activity toward the beta- and epsilon-rings of alpha-carotene. No activity with acyclic carotenoids such as lycopene and neurosporene. Uses ferredoxin as an electron donor.
Subcellular location: Plastid, chloroplast membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Lycopene beta cyclase, chloroplastic
- Zeaxanthin epoxidase, chloroplastic
- Carotene epsilon-monooxygenase, chloroplastic
- Protein LUTEIN DEFICIENT 5, chloroplastic
- Violaxanthin de-epoxidase, chloroplastic
- Beta-carotene isomerase D27, chloroplastic
- Beta-carotene 3-hydroxylase 1, chloroplastic
- Phytoene synthase 1, chloroplastic
- 15-cis-phytoene desaturase, chloroplastic/chromoplastic
- Lycopene epsilon cyclase, chloroplastic
Sequence:
MAAGLSTIAVTLKPLNRSSFSANHPISTAVFPPSLRFNGFRRRKILTVCFVVEERKQSSPMDDDNKPESTTSSSEILMTSRLLKKAEKKKSERFTYLIAAVMSSFGITSMAIMAVYYRFSWQMKGGEVSVLEMFGTFALSVGAAVGMEFWARWAHRALWHDSLWNMHESHHKPREGAFELNDVFAITNAVPAIGLLYYGFLNKGLVPGLCFGAGLGITMFGMAYMFVHDGLVHKRFPVGPIANVPYLRKVAAAHQLHHTDKFKGVPYGLFLGPKEVEEVGGKEELEKEISRRIKLYNKGSSTS
Protein: UvrABC system protein A (Excinuclease ABC subunit A) (Q9RYW8)
Organism: Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- UvrABC system protein B
- UvrABC system protein C
- UvrABC system protein A
- DNA 3'-5' helicase
- Transcription-repair-coupling factor
- Ribosomal protein uS12 methylthiotransferase RimO
Sequence:
MVTSSSMRRCRGALSLSFWIFLVLRSVLSRPVFGAAAGPAVQSARQCSASRGTGESDPPPFQPTLRLFPPSRRRRSYCRAMTPSRPSPDFPDGGFVQVRGARQHNLKDISVKVPRDALVVFTGVSGSGKSSLAFGTLYAEAQRRYLESVSPYARRLFNQAGVPDVDAIDGLPPAVALQQARGTPTARSSVGSVTTLSNLLRMLYSRAGDYPPGQGIVYAEGFSPNTPEGACPECHGLGRVYTVTEDSMVPDPSLTIRERAVAAWPQAWGGQNQRDILVTLGIDVDVPWRELPEETRHWILFTDEQPVVPVYPGLTPAETQRALKKKMEPSYMGTFSSARRHVLHTFANTESASMKKRVQGYMISEECPLCHGKRLRQEALNVTFAGLDITELSRLPLARVSELLRPYAEEREPGHAERVKNRPEQAIALQRMAADLVKRLDVLLHLGLGYLGLDRSTPTLSPGELQRLRLATQLYSNLFGVVYVLDEPSAGLHPADTEALLSALENLKRGGNSLFVVEHDLDVIRRADWLVDVGPEAGEKGGEILYSGPPEGLKHVPESQTGQYLFADRHTEPHTPREPAGWLELNGVTRNNLDNLDVRFPLGVMTSVTGVSGSGKSTLVSQALVDALAAHFGQPVNPDPEDDEDPADHTAGSARLGGDLAQITRLVRVDQKPIGRTPRSNMATYTGLFDQVRKLFAATPLAKKRGYNAGRFSFNVKGGRCEHCQGEGWVMVELLFLPSVYAPCPVCHGTRYNAETLEVEYRGKNIADVLALTVDEAHDFFADESAIFRALDTLREVGLGYLRLGQPATELSGGEAQRIKLATELQRSGRGGTVYVLDEPTTGLHPADVERLQRQLVKLVDAGNTVIAVEHKMQVVAASDWVLDIGPGAGEDGGRLVAQGTPAEVAQAAGSVTAPYLRAALR
Protein: COMM domain-containing protein 5 (Q8MQV6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSTFRYNLLRSVKPYTSFTPQLTKSMLRVLIQVSVHYIESKKSSSEVLSLALNKLTNGGHKIPPNFCELFTMVFLTMQIFLRYPKGVVKHHELRKCLMDDLNLTEEYVEDICKVLLNHRDVLSKNFSDTKMDRVKMSKLQWRINISLSLNTVQIDKPTIVLHFKLQNKEYRTLELPLSMFQQVRYNIALLLNELQSLQSRLALK
Protein: MPL proto-oncogene, thrombopoietin receptor (A0A1W2Q6N1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Thrombopoietin
- Tyrosine-protein kinase JAK2
- Erythropoietin
- Interleukin-3
- Tyrosine-protein kinase JAK3
- Granulocyte-macrophage colony-stimulating factor
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Integrin subunit alpha 2b
- Granulocyte colony-stimulating factor
Sequence:
MPSWALFMVTSCLLLAPPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTCFWDEEEAAPSWIYQLLYAYPGEKPRPCPLHSQSVPTFGTRYVCQFPALDEVRLFFPLHLWVKNVFLNQTLMQRVLFVDTVGLPAPPSVIKARGGSQPGELQIHWEAPAPEISNFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLRMPNPVRVLDQHPCVHPTASQQHGPMRTSPAGEAPSLAVKGGSCLISGLHAGQSYWLQLRSQPDGVSLRGSWGPWSLPVTVDLPGDAVAIGLQCFTVDLKKVICQWQQQDHSSSRGFFRHSRTRCCPTDRDPTWEKCEEEEEEEEEEKEEGELDPGSRPALFSRCHFKSRNDSVIHILVEVTTAQGAIHSYLGSPFWIRQAVLLPTPSLHWREISSGRLELEWQHPSPWAAQETCYQLRYTGEGHEDWKVLEPSLGAQGGTLELRPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLGLLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSLLEILPKSPERTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPTAETGSCCTTHIANHSYLPLSYWQQP
Protein: Homeobox containing 1 (H0YKJ1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MLSSFPVVLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDKFGRRSSYGGSSYGNSTNNVPASSSTATASTQTQHSGMSPSPSNSYDTSPQPCTTNQNGRENNERLSTSNGKMSPTRYHANSMGQRSYSFEASEEDLDVDDKVEELMRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKKRAFYRWYQLEKTNPGATLSMRPAPIPIEDPEWRQTPPPVSATSGTFRLRRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRRKEIKRRANIEAAILESHGIDVQSPGGHSNSDDVDGNDYSEQVSPCAAGRGSWCLSRGYSGTA
Protein: Cytochrome b translational activator protein CBS1, mitochondrial (COB-specific translational activator protein CBS1) (P14066)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: mRNA-specific translational activator of cytochrome b. The cytochrome b (COB) leader RNA may represent the target sequence for CBS1 and CBS2, tethering the COB mRNA to the inner mitochondrial membrane, where cotranslational insertion of cytochrome b into the membrane can occur.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:1745228}; Peripheral membrane protein {ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:1745228}.
Interaction partners:
- Cytochrome B translational activator CBS2
- Cytochrome B pre-mRNA-processing protein 6
- Cytochrome b mRNA maturase bI3
- Cytochrome b mRNA maturase bI2
- Cytochrome B pre-mRNA-processing protein 2
- Cytochrome b termination protein 1
- Cytochrome b
- Cytochrome B pre-mRNA-processing protein 1
Sequence:
MLRTKVFATTVARISGIRRYIPIRTINTVTKKNISKIEKLCEVLEVNPDGYKGKERIPTKELTKLLYTTSRNMLVRVPMTGDLSTGNTFETRNETLQKLGEQLIHLEINKMLTITFTNFNQFNIMNKNFNYIHNLDRARVVNMDSISWLIKNSLKINQLAHLRIPANLPKEMGLTSSSNDFQNLNDWKVILSFIGYLKLLEIKNDNKKFIESIIKTICIPLINYHLRKS
Protein: Intracellular protein transport protein uso1 (Q09857)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for protein transport from the ER to the Golgi complex.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- GTP-binding protein ypt1
- Integral membrane protein sed5
- Protein transport protein bos1
- Protein transport protein gos1
- Protein transport protein bet1
- Synaptobrevin homolog ykt6
- Uncharacterized protein C1D4.02c
- Protein sly1
- GRIP domain-containing protein C119.12
- Protein transport protein sft1
Sequence:
MDIFHKSYNVILSPPKVQQADETISKLCDRLEHATLFEDRKAAALGIKSFAREFKELVAAHGLKGIIQSLHRDYDDPELLKVTLETCLILTRHDDDSRASDTGLWIADQFILNQDNIQCLLQSISHKDFYVRLYSVELFSAILSCRPTELKDCLQTFPSAISSIMVPLRDSIEPVRNADLYFLSELVKDCTSIQKLVVFENAFETLFSLLENEGGVDGGIIALEALKFLNVLLKDNISNQNYFRESNHIPSLLKLLSVDTFVDGTWDTSRVQCVIEALYALQSLVPIGLSSSIANQNAVVSNHGIDVLLTLATHPDLLFFDVQKISWITLAHVVYSNARAQNSFVDSTFFDIKNTDVLTCLFDYLFLSSISPSHRYSVAFFLRSLTSENDELSSKFLKQIIHAYTHKQDNRLNIIQGYLDLVHLSDQDQYDNWFTSTILTYLVIDNDQRKYLLCSIPLFQDMDNDEDSESEDKVTFIQCVSTKLIATLRHENALQNCVGYLTLLIALVYGNPDSVKDFLSESSILQTFLTALMDESSSANSVIQGMIAVFLSLVYYYCPIESPVSKSDVYNAITSAVKRDVFINRLQRLRRMNLYEITFLSMKQKMHAIDDAADAFNTKIGEINTLDAFDEAQKQLKSLREEIDNTKEALDLSVKERSIQEEKLNESLKTSKTNLEEQTQLAEKYHEELLDNQQKLYDLRIELDYTKSNCKQMEEEMQVLREGHESEIKDFIEEHSKLTKQLDDIKNQFGIISSKNRDLLSELEKSKSLNNSLAALESKNKKLENDLNLLTEKLNKKNADTESFKNTIREAELSKKALNDNLGNKENIISDLKNKLSEESTRLQELQSQLNQDKNQIETLNERISAAADELSSMESINKNQANELKLAKQKCSNLQEKINFGNKLAKEHTEKISSLEKDLEAATKTASTLSKELKTVKSENDSLKSVSNDDQNKEKSVNNEKFKEVSQALAEANEKLNARDEEIERLKVDIIGLQNASLNMQSLKDSDNRTISDLESKNKELEKKLKEADEYWLLIVEELESKRTKDKELLRQCGQAVSEDEQSEEE
Protein: Ribonuclease PH (RNase PH) (EC 2.7.7.56) (tRNA nucleotidyltransferase) (P28619)
Organism: Bacillus subtilis (strain 168)
Function: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. Plays a role in the secondary pathway of 23S rRNA 3' end maturation.
Interaction partners:
- Ribonuclease R
- dITP/XTP pyrophosphatase
- 3'-5' exoribonuclease YhaM
- Ribonuclease Z
- Ribonuclease 3
- Rhamnulokinase
- Probable metallophosphoesterase YsnB
- ADP-ribose pyrophosphatase
- L-ribulose-5-phosphate 4-epimerase
- Small ribosomal subunit protein bS1 homolog
Sequence:
MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVEDRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVVDLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLAAISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGLLGLAEKGIQELIDKQKEVLGDSLPELK
Protein: Probable short-chain type dehydrogenase/reductase (O50460)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Multifunctional 2-oxoglutarate metabolism enzyme
Sequence:
MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTDGLADTEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTGDIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLFSAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVKTAIARNATAAEGLDQAELAETFDKRVAHLSPQRAAQIILTGVAKNKARVLVGVDAKVLDLVVRLTGSGYQRIFPIITGRLIPRPR
Protein: Protein Wnt (A0A8I6AN69)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
Sequence:
MLYHFTECTVRRNEESAYGELRFGRNGCISRLRLQVPVSRMEGTELIGGVLAKVQGWKPRAQGQGVANLALQGAFRSHHRPLYLSIVALNSVCPSTKRIILRSGLLRATGGSLALHPMTATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYALFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCVFHWCCYVSCQECIRIYDVHTCK
Protein: L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) (Sperm antigen P26h) (Q91XV4)
Organism: Mesocricetus auratus (Golden hamster)
Function: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Subcellular location: Membrane {ECO:0000269|PubMed:9890754}; Peripheral membrane protein {ECO:0000269|PubMed:9890754}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:9890754}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. During epididymal transit, it accumulates on the acrosomal cap of spermatozoa.
Interaction partners:
- aldose reductase
- L-xylulose reductase-like isoform X1
- Carbonyl reductase
- Sorbitol dehydrogenase
- aldose reductase
- Cytochrome P450 2E1
- aldose reductase
- Cyanocobalamin reductase / alkylcobalamin dealkylase
Sequence:
MDLGLAGRRALVTGAGKGIGRSTVLALQAAGAHVVAVSRTQADLDSLVSECPGVETVCVDLADWEATEQALSSVGPVDLLVNNAAVALLQPFLEVTKEAFDMSFNVNLRAVIQVSQIVARGMIARGAPGAIVNVSSQASQRALANHSVYCSTKGALDMLTKMMALELGPHKIRVNAVNPTVVMTSMGRTNWSDPHKAKVMLDRIPLGKFAEVENVVDAILFLLSHRSNMTTGSTLPVDGGFLVT
Protein: AT3G15770 protein (B9DGF6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ethylene-responsive transcription factor 11
Sequence:
MGSSCLACFDKSKAKTSVDVPLNGTKDVLVEEDWSELRKPSVVASEDFWTNTTLDMESNAHGSVSSISTTNLTIDSQGCGSSSNEPAEFVNHGLVLWNQTRQQWVGDKRSESRKSVGREPILNENVTYESLLGSNKRFPRPIPLDEMVQFLVEVWEEEGLYG
Protein: Bazooka protein (O96782)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKVTVCFGDVRILVPCGSGELLVRDLVKEATRRYIKAAGKPDSWVTVTHLQTQSGILDPDDCVRDVADDREQILAHFDDPGPDPGVPQGGGDGASGSSSVGTGSPDIFRDPTNTEAPTCPRDLSTPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLFLDKAGGQLSPQWEEDDDPSHQLKEQLLHQQQPHAANGGSSSGNHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGQLRRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKVADMVEVATVSPTRKPHAAPVGTSLQVANTRKLGRKIQIMLKKGPNGLGFSVTTRDNPAGAHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLAVGNQGPPINTVPGTPSTSSNFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAALDARETGTYQRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAAAEAEARDQLGDLGPSLGMKKSSSLESLQTMVQELQMSDEPRGHQALRAPRGRGREDSLRAAVVSEPDASKPRKTWLLEDGDHEGGFASQRNGPFQSSLNDGKHGCKSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALAALERNGKPPAYQPPPPLPAPNGVGSNGIHQNDIFNHRYQHYANYEDLHQQHQQHQISRRHQHYHSQRSARSQDVSMHSTSSGSQPGSLAQPQAQSDGVRPMSSYYEYETVQQQRVGSIKHSHSSSATSSSSSPINVPHWKAAAMNGYSPASLNSSARSRGPFVTQVTIREQSSGGIPAHLLQQHQQQQLQQQQPTYQTVQKMSGPSQYGSAAGSQPHASKV
Protein: tRNA (adenine(58)-N(1))-methyltransferase TrmI (EC 2.1.1.220) (tRNA(m1A58)-methyltransferase) (tRNA(m1A58)MTase) (Q8GBB2)
Organism: Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Function: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. Is required for cell growth at extreme temperatures.
Interaction partners:
Sequence:
MAWPGPLLLKDRKGRAYLVFPKEGGVFHHHKGSVPHEALLEAGPGGVVRTHLGEELSVHRPTLEEYLLHMKRSATPTYPKDASAMVTLLDLAPGMRVLEAGTGSGGLTLFLARAVGEKGLVESYEARPHHLAQAERNVRAFWQVENVRFHLGKLEEAELEEAAYDGVALDLMEPWKVLEKAALALKPDRFLVAYLPNITQVLELVRAAEAHPFRLERVLEVGWREWEVRLPVAHPRFQQVGHTAFLVALRRWKAS
Protein: ARM repeat superfamily protein (At1g23180) (Q8H0U3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g63610
- Alanine-tRNA ligase, putative
- At1g32160/F3C3_6
- At5g52960
- At4g33110
- Electron transporter, putative
- Thioredoxin domain-containing protein
- Pentatricopeptide repeat
- AT3g29240/MXO21_9)
- Uncharacterized protein At3g49140
Sequence:
MSLSTIASGIGVLELPCLRLLPISSTQIQFLTVEARKQSRRIRRERSFSPFPVLIQSNRRLRHGFSELNSSFDRSNSGETGSDTTLKDGEEVRSESSSGVGDSYVGLFVGMLGLDNDPLDREQAIETLWKYSLGGKKCIDAIMQFHGCLNLIVNLLKSESSSACEAAAGLIRSIASVNLYRESVAESGALEEITALLSRPSLATVVKEQCICALWNLTVDEEIREKVADFDILRLLISFLEDDDVNVKEAAGGVLANLALSRSTHKILVEVGVIPKLAKLLKADNTENKGSKVIRKEARNVLLELAKDEYYRILVIEEGVVPIPIIGADAYKSFRPDLYSWPSLPDGINIEQTAKAPSRFGASELLLGLNVDKNVDDVDEAKMKAIVGRTNQQFLARIGAIEFEKEIKSEGPGKSQQLTLLPCVDGVARLVLILGLADELAATRAAESIADASINEDMRVSFMEAGAVKPLVQLLANNNKETVKLPVIRALKNLSLSRTVCQRIEAEGAVWFLINLLKQPEISLNVTEHVLDIIAHILDPSKEMESKFYEGPVNGSKADSRKEVLDAAVFSRLVQIAKTASPNLLRNAISVIEFGIISNPNMDTIISKDITTVLDLALRQKVLEEPENEAEELEKHLLKLEEAGLTISAASRLLTKLLDSESFRQTIDTAVFIELVRKILRSSLPLHYKDWVAACLVKLTALSSPSQSLNNPINLEVTLYKTIPSLVEQMSFSSSPETKEAAVLELNKIVSEGVPESIQTLASQGGIEPLVKLLEERNERCVEASLSVLYNLTMDSENHTAIIRAGAVPVLRRIVMSQRPQWEKALRLLRNLPV
Protein: Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) (Q92551)
Organism: Homo sapiens (Human)
Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11502751}. Nucleus {ECO:0000269|PubMed:11502751}.
Interaction partners:
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
- Inositol-pentakisphosphate 2-kinase
- Inositol hexakisphosphate kinase 2
- Inositol hexakisphosphate kinase 3
- Guanine nucleotide exchange factor for Rab-3A
- UBX domain-containing protein 4
- Inositol-trisphosphate 3-kinase B
- Exosome complex component RRP42
- Inositol-trisphosphate 3-kinase A
Sequence:
MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ
Protein: RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (RNA-binding motif protein 9) (RNA-binding protein 9) (S4R469)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGF
Protein: NUP-1 protein (Q388X1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
METHLGWKDASLYADRSPSRKADERVNRSGSRAPGAGPRTIDISSPKGELGIASRSASAFGRRSGTSSPLERVIDGADVIGGLSCTRDLHRGLMEQKLQNIQHEADVMQEELKETNSRLSRVTKQLNEQKVEFSSLTQRYGETVEKLTATEGSVKRLEEHLVHERQQHANVRGECDRLKTMLQETQWEVERARRELQQERERPTVDQSEVQRLLNDRTRYIPTGEVQQRIDEIRDTHKAFAGRLTDSFSVLLRAQEEDEASAIATRNSVLSLVAEFESKLNGVEDVLTSLQEQMLAFSEVSEQETMEMINTLIVENKELWKHLSKLKGENETLSTKLEAERRRGDVVPRDQHECTQKKLALTTDKLTDALEAIETQTRQRKAHEAQINELKATNRSLKDQIKRLTGDISAAQAEAGQCKDQLRENKITVKESTRRADELWELLSVERRQSGEKIAQMTEDCKKLRRDCENLSERLAKEQEKARKECQRLKDELHKAEESAKTLQRELNNRDLSFENYKQQSEGQQQEMARSMKEDLAKTKKRLEHELDVTQRRLQKQLDAVGELERERDKERSERRAVEATVAKLEAELAGLRTENQQQQYRLQQLTERTQRMDLEADHLRQKRDSAENEVRQLQLELNRLQDQKCEVEQQLAKERETHTHDSQKYKEDVQKIDKNSNTLQEKLHKARLRITELEQQQQKSLKEADDEKKLEEKNLQLQTQNREVKLENESLREEIKRINKKMKSVEHLSKQLEDARERLLVLPALREAAEEARRDVERAVEETEALRQERDTMAEKLDSFLDIRRRAPKTDVEWTHLLHNVKEQVQQLDGKPSMPRSWKQQEGIPLSITTRPGGYSEMYRNNQRSLSGGRKQQQCSATQGCCQLVESPTQSNGATMPRPWR
Protein: Neurturin (P97463)
Organism: Mus musculus (Mouse)
Function: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
Subcellular location: Secreted {ECO:0000269|PubMed:8945474}.
Interaction partners:
- GDNF family receptor alpha-2
- GDNF family receptor alpha-1
- GDNF family receptor alpha-3
- Proto-oncogene tyrosine-protein kinase receptor Ret
- GDNF family receptor alpha-4
- Syndecan-3
- Beta-nerve growth factor
- BDNF/NT-3 growth factors receptor
- Neurotrophic factor BDNF precursor form
- Persephin
Sequence:
MRRWKAAALVSLICSSLLSVWMCQEGLLLGHRLGPALAPLRRPPRTLDARIARLAQYRALLQGAPDAVELRELSPWAARIPGPRRRAGPRRRRARPGARPCGLRELEVRVSELGLGYTSDETVLFRYCAGACEAAIRIYDLGLRRLRQRRRVRRERARAHPCCRPTAYEDEVSFLDVHSRYHTLQELSARECACV
Protein: SH3 domain-containing protein (Q38CA7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNLSNRVVAFPYTPPPEAKYANLCLQAKAGEEVQVVRQVGGWAVLKLGERMGLFPLAYTVKKKDVKAGNGESSGVSVGCPLENENESVTKTDGCPEFFMEGGSVVTDAEPPAQRAVRNHGNLKRPGCDRISLDFHVSGESEVANTADDAECNVLFTRVRCLPDESEREMPDGSGGAETEVIRKGDRTTTGNELRDAACVLSARKLPEETIGRRGKLRKMPQSRHGDMDYRDNFEEAVGELRGQFVELDMEVEWLNSVTDRLQAVRQNLVGACTSRNETCGSQQLQEGENEGKNHGDQFDAATLKQYVSQLQQSLVAYKAKSDTAPASSADGGLAGCEGATATAAKQNGGECTDGFEVPWWWVISAELRAEMQSIRECIWRELETLSYYSGQRQRLCANADRLLCLKTSMDEESWTLKESEDALEVVAPAGTFKIAYGTGSNNSSYLTDSSHENSFVNSNQDTSLSLAPEGSREDVEVVMKEGFVWPASIPGMLDNEKNVVETHQRAIKKYEEKLEKLRKGKGEEAFERMRAMEKLRKALSTGDAALSALLNRLNEKKAFVMRYRNVAAIMEEQLAISRKLLQQKRVNSRGNPKSPQQAEPTN
Protein: Large ribosomal subunit protein mL44 (EC 3.1.26.-) (39S ribosomal protein L44, mitochondrial) (L44mt) (MRP-L44) (Q2KIS2)
Organism: Bos taurus (Bovine)
Function: Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9H9J2}.
Interaction partners:
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein mL50
- Large ribosomal subunit protein mL51
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein bL34m
- Large ribosomal subunit protein mL65
Sequence:
MASGLTRLLLRGPRCLLATAGLTLIPPVRGVKKGFRAAFRFQKELERWRLLRCPPPPVRRSEKPNWDYHAEIQAFGPRLQETFSLDLLKTAFVNSCYIKSEEAKRQKLGIEKEAVLLNLKDNQELSEQGTSFSQTCLTQFFEDAFPDLPTEGVKSLVDYLTGEEVVCHVARNLAVEQLTLSADFPVPPAVLRQTFFAVIGALLHSSGPERTSLFIRDFLITQMTGKELFEIWKIINPMGLLVQELKKRNISVPESRLTRQSGSTTALPVYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKLYGFTENRQPWDYSRPKEPVRAEKTIAAS
Protein: Endoribonuclease Dicer homolog 2 (EC 3.1.26.-) (Dicer-like protein 2) (AtDCL2) (Q3EBC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ribonuclease (RNase) III involved in RNA-mediated post-transcriptional gene silencing (PTGS). Involved in the processing of natural small interfering RNAs (nat-siRNAs, derived from cis-natural antisense transcripts) by cleaving small dsRNAs into 24 nucleotide nat-siRNAs. Plays an essential role in transitive silencing of transgenes by processing secondary siRNAs. This pathway, which requires DCL4 and RDR6, amplifies silencing by using the target RNA as substrate to generate secondary siRNAs, providing an efficient mechanism for long-distance silencing. May participate with DCL3 in the production of 24 nucleotide repeat-associated siRNAs (ra-siRNAs) which derive from heterochromatin and DNA repeats such as transposons. Plays a role in antiviral RNA silencing. Involved in the production of viral siRNAs derived from the turnip crinkle virus (TCV) and tobacco rattle virus (TRV). Targeted by the viral silencing suppressor (VSR) protein 2b of the cucumber mosaic virus (CMV) that inactivates DCL2 function in RNA silencing. Does not seem to be involved in microRNAs (miRNAs) processing.
Subcellular location: Nucleus {ECO:0000269|PubMed:15024409}. Cytoplasm {ECO:0000269|PubMed:15024409}.
Interaction partners:
- RNA-dependent RNA polymerase 2
- Protein argonaute 2
- Protein DCL homolog, chloroplastic
- RNA-dependent RNA polymerase 6
- Protein argonaute 1
- Protein argonaute 4
- Protein argonaute 7
- Protein argonaute 6
- Protein argonaute 5
- Protein argonaute 10
Sequence:
MTMDADAMETETTDQVSASPLHFARSYQVEALEKAIKQNTIVFLETGSGKTLIAIMLLRSYAYLFRKPSPCFCVFLVPQVVLVTQQAEALKMHTDLKVGMYWGDMGVDFWDSSTWKQEVDKYEVLVMTPAILLDALRHSFLSLSMIKVLIVDECHHAGGKHPYACIMREFYHKELNSGTSNVPRIFGMTASLVKTKGENLDSYWKKIHELETLMNSKVYTCENESVLAGFVPFSTPSFKYYQHIKIPSPKRASLVEKLERLTIKHRLSLGTLDLNSSTVDSVEKRLLRISSTLTYCLDDLGILLAQKAAQSLSASQNDSFLWGELNMFSVALVKKFCSDASQEFLAEIPQGLNWSVANINGNAEAGLLTLKTVCLIETLLGYSSLENIRCIIFVDRVITAIVLESLLAEILPNCNNWKTKYVAGNNSGLQNQTRKKQNEIVEDFRRGLVNIIVATSILEEGLDVQSCNLVIRFDPASNICSFIQSRGRARMQNSDYLMMVESGDLLTQSRLMKYLSGGKRMREESLDHSLVPCPPLPDDSDEPLFRVESTGATVTLSSSVSLIYHYCSRLPSDEYFKPAPRFDVNKDQGSCTLYLPKSCPVKEVKAEANNKVLKQAVCLKACIQLHKVGALSDHLVPDMVVAETVSQKLEKIQYNTEQPCYFPPELVSQFSAQPETTYHFYLIRMKPNSPRNFHLNDVLLGTRVVLEDDIGNTSFRLEDHRGTIAVTLSYVGAFHLTQEEVLFCRRFQITLFRVLLDHSVENLMEALNGLHLRDGVALDYLLVPSTHSHETSLIDWEVIRSVNLTSHEVLEKHENCSTNGASRILHTKDGLFCTCVVQNALVYTPHNGYVYCTKGVLNNLNGNSLLTKRNSGDQTYIEYYEERHGIQLNFVDEPLLNGRHIFTLHSYLHMAKKKKEKEHDREFVELPPELCHVILSPISVDMIYSYTFIPSVMQRIESLLIAYNLKKSIPKVNIPTIKVLEAITTKKCEDQFHLESLETLGDSFLKYAVCQQLFQHCHTHHEGLLSTKKDGMISNVMLCQFGCQQKLQGFIRDECFEPKGWMVPGQSSAAYSLVNDTLPESRNIYVASRRNLKRKSVADVVESLIGAYLSEGGELAALMFMNWVGIKVDFTTTKIQRDSPIQAEKLVNVGYMESLLNYSFEDKSLLVEALTHGSYMMPEIPRCYQRLEFLGDSVLDYLITKHLYDKYPCLSPGLLTDMRSASVNNECYALVAVKANLHKHILYASHHLHKHISRTVSEFEQSSLQSTFGWESDISFPKVLGDVIESLAGAIFVDSGYNKEVVFASIKPLLGCMITPETVKLHPVRELTELCQKWQFELSKAKDFDSFTVEVKAKEMSFAHTAKASDKKMAKKLAYKEVLNLLKNSLDY