wanglab/gogpt-training-data huggingface dataset:
Protein: 2-isopropylmalate synthase 2, chloroplastic (EC 2.3.3.13) (2-isopropylmalate synthase 1) (Methylthioalkylmalate synthase-like 3) (Q9C550)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Involved in Leu biosynthesis, but does not participate in the chain elongation of glucosinolates.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Dihydroxy-acid dehydratase, chloroplastic
- 3-isopropylmalate dehydratase small subunit 3
- 3-isopropylmalate dehydratase small subunit 1
- 3-isopropylmalate dehydratase small subunit 2
- 3-isopropylmalate dehydratase large subunit, chloroplastic
- Branched-chain-amino-acid aminotransferase 2, chloroplastic
- Branched-chain-amino-acid aminotransferase 6
- Branched-chain-amino-acid aminotransferase 5, chloroplastic
- Branched-chain-amino-acid aminotransferase 1, mitochondrial
- Branched-chain-amino-acid aminotransferase 3, chloroplastic
Sequence:
MESSILKSPNLSSPSFGVPSIPALSSSSTSPFSSLHLRSQNHRTISLTTAGKFRVSYSLSASSPLPPHAPRRRPNYIPNRISDPNYVRIFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTIAETVGNTVDENGYVPVICGLSRCNKKDIETAWEAVKYAKRPRIHTFIATSDIHLKYKLKKSKEEVIEIARNMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTVGITLPSEFGQLIADIKANTPGIQNVIISTHCQNDLGLSTANTLSGAHSGARQVEVTINGIGERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGANAFAHESGIHQDGMLKHKGTYEIMSPEEIGLERSNDAGIVLGKLSGRHALKDRLNELGYVLDDGQLSNLFWRFKAVAEQKKRVTDADLIALVSDEVFQPEAVWKLLDMQITCGTLGLSTSTVKLADSDGKEHVACSVGTGPVDAAYKAVDLIVKEPATLLEYSMNAVTEGIDAIATTRVLIRGDNNYSSTNAVTGESVERTFSGTGAGMDIVVSSVKAYVGALNKMLGFKEHTSTLSKTPLETNEVPA
Protein: Distal tail protein (Dit) (Gene product 15) (Gp15) (D3WAD3)
Organism: Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)
Function: Forms the distal part of the tail. Self-associates as two rings organized back to back, with a central channel allowing DNA ejection.
Subcellular location: Virion {ECO:0000269|PubMed:20351260}. Note=Part of the tail. {ECO:0000269|PubMed:20351260}.
Interaction partners:
Sequence:
MVRQYKIHTNLDGTDDKVWDVTNGKVRFYQPSNLGLQSTNNIWQSNGIGVMGTRSITQPQIEFKLETFGESLEENYQLMKDFVNDILSKKFVTLEYQTEIFQVYADLALADVTKTEGYGKNGTFSEKITFDIITKWYTYENLTFDKIQNGKVIAGMSKIYGGTAPGNYKYIKGTSYTYYGESDIDRLSRWDIKEEIFSFMGILYPKLPKTPAGVRFLDDIGNEYTAIVFKTEQVQDYILINTDVNDETYQGWKGTTALNLFPVMDFERYRTRIIEKGQMELINLSKAEFKIKRKADFV
Protein: Nuclear receptor subfamily 4 group A member 2 (Q6DH08)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MPCVQAQYGTSPPGASPASQSYSYNTTGEYNCDFLTPEFVKFSMDLTNAEIAVTSSLPSFSTFVDTYSSNYDVKPPCLYQMAHSGDQLSIKVEEIPAHGYHQQQHHQPHQAEESIPHTGAIYYKPSSPNISQSPSYPTAPHHTWEDTGSLHSFHQNYLATSHIMDQQRKNAMSRLFSFKQSPVDTPMPSCQMRFDGSLHVSMGPDTAHRALDSFALPAPPRKQHGVGLSHSLNVGHPLLESPVASPQARGSPSSEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLVVGMVKEVVRTASLKGRRGRLPSKPKSPQDIPVSFTPVNLLNALVRAHIDSNPSMARLDYSKFQTSPEYHSGGDESLHIQQFYDLLTASMSIIRGWAEKIPGFTELPKCDQELLFESAFLELFVLRLAYRSNLPEDKLIFCNGMVLHKLQCVRGFGEWIDSIVEFSSNLQSMSLDVSAFSCIAALTIVTERHGLKEPKKAEELQNKLINCLKDQVSCSGELSKLLEKLPEVRALCTQGLQRIFYLKLEDLVPTPAIIDKLFHDTLPF
Protein: Catalase isozyme B (CAT-B) (EC 1.11.1.6) (Q0D9C4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide (By similarity). May prevent the excessive accumulation of H(2)O(2) during water stress in response to the accumulation of abscisic acid (ABA). Involved in the modulation of ROS levels related to root growth regulation (Ref.11). Required for pollen viability and floret fertility upon heat stress (HS) by detoxifying reactive oxygen species (ROS) and malondialdehyde (MDA) accumulation in developing anthers exposed to HS.
Subcellular location: Peroxisome {ECO:0000269|PubMed:26900141, ECO:0000305|PubMed:21398647}. Glyoxysome {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:29581216}.
Interaction partners:
- Os09g0544900 protein
- Peroxisomal
- Catalase isozyme A
- Catalase isozyme C
- Superoxide dismutase, mitochondrial
- Superoxide dismutase 2, chloroplastic
- Superoxide dismutase 2
- Superoxide dismutase 1
- Os06g0211300 protein
- Os02g0765800 protein.
Sequence:
MDPYKHRPSSGSNSTFWTTNSGAPVWNNNSALTVGERGPILLEDYHLIEKLAQFDRERIPERVVHARGASAKGFFEVTHDISHLTCADFLRAPGVQTPVIVRFSTVVHERGSPETLRDPRGFAVKFYTREGNFDLVGNNMPVFFIRDGMKFPDMVHAFKPSPKTNMQENWRIVDFFSHHPESLHMFSFLFDDVGIPLNYRHMEGFGVNTYTLINKDGKPHLVKFHWKPTCGVKCLLDDEAVTVGGTCHSHATKDLTDSIAAGNYPEWKLYIQTIDPDHEDRFDFDPLDVTKTWPEDIIPLQPVGRMVLNKNIDNFFAENEQLAFCPAIIVPGIHYSDDKLLQTRIFSYADTQRHRLGPNYLMLPVNAPKCAYHNNHHDGSMNFMHRDEEVNYFPSRFDAARHAEKVPIPPRVLTGCREKCVIDKENNFQQAGERYRSFDPARQDRFLQRWVDALSDPRITHELRGIWISYWSQCDASLGQKLASRLNLKPNM
Protein: Uncharacterized protein (Q38BJ4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQQVGEPFPSEELRGSNDYQGCKWYRTEGVHSSMDSNIVSTGAACEYSGPCVLRSFRTAPAISWESFQVIRKGKVVLGGAHEGAIAEDLAKLSNIYNKTDGPTSTNTNSNNPSGARGNDINLPVKSIGKFLEDQLPGLCDKRGDSLYRGATFLLLGVLTGNIALAERCLEWGANPNEMSFLSEPFATLDQMRHGYSPMFVAIITGNIAMMNLLHSAGGSLIVYDRWGRTPLHAALALADREVIQWLVEKGAPRCLGNTAPVLQGVTMCPDLSPVNLALNPRPKLSIGHQVGLPGNDEAKIVDMKEGDTEKAALCHCWSGLPKGYCGCIDDMFLRWSYDRLHSRWQPGITFTETSAAHPSKASKRPKAA
Protein: RING-type E3 ubiquitin transferase BRCA1 (Q9ZW89)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
Interaction partners:
- Nibrin homolog
- Protein BREAST CANCER SUSCEPTIBILITY 1 homolog
- Dentin sialophosphoprotein-like protein
- Serine/threonine-protein kinase ATM
- Protein TRAUCO
- Structural maintenance of chromosomes protein 6A
- BRCT domain-containing protein At4g02110
- DNA repair protein RAD50
- Structural maintenance of chromosomes protein 6B
- Transcription coactivator
Sequence:
MENVVATVSGYHGSDRFKLIKLISHSGASYVGAMSRSITHLVCWKFEGKKYDLAKKFGTVVVNHRWVEECVKEGRRVSETPYMFDSGEEVGPLMIELPAVSEEAKVTKKVNKASETFDKYFSNGGENRSGSTSELATWMEKNVEANRHSVRLRTKRPSSILENKENSGVAESSRKGKKRVVKQRSYRNLIDLESDEESDNNHHDNSDENQNETQDHREPADENVRGFVFEQGETSALRHPGDLATPNWDVDEIEESENWSHSAVFKRPRSFSPEIKPQDDDESTREETEATEKAPAQVSCIICWTEFSSSRGILPCGHRFCYSCIQKWADRLVSERKKTTCPLCKSNFITITKIEDADSSDQKIYSQTVPDLSSTNNILVVLPEEEEQRQTLNPLTRASGCSRCYLTEPEELLIRCHLCNFRRIHSYCLDPYLLPWTCNHCNDLQMMYHRRNY
Protein: Glutathione S-transferase GstA (EC 2.5.1.18) (E9R0R8)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- Glutathione reductase
- Glutathione synthetase
- glutathione-specific gamma-glutamylcyclotransferase
- Calcium/calmodulin-dependent protein kinase, putative
Sequence:
MANRPDITLYTTQTPNGIKISIALEELGLPYKVEKIDISKNTQKEPWFLEINPNGRIPALTDTFTDGQKIRLFESGSILTYLAEQYDKDYKISYPRGTREYYETISWLYFQNAGVGPMQGQANHFVRYASEHIQYGVDRYVNETRRLYGVLDKHLSTSKSGYLVGDHVTIADISHWGWVAAAGWAGVNIDEFPHLKAWEERMAARPGVEKGRHVPAPHTIKDLLKDKERMEQEAAKTRQWVQQGMKSDANKAKH
Protein: Toll-like receptor 7-long (Q5ZJD0)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasmic vesicle, phagosome {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Endosome {ECO:0000256|ARBA:ARBA00004177}. Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Interaction partners:
Sequence:
MTNLSEVAAHRKMVHHARTSNALLFVLLFLFPMLLSGRWFPKTLPCDVEAFESTVRVDCSDRRLKEVPRGIPGNATNLTLTINHIPRISPVSFTQLENLVEIDFRCNCVPPRLGPKDNVCITPPSIENGSFAALSRLKSLYLDANQLSKIPRGLPATLRLLSLEANNIFSIKKNTFSELRNIELLYLGQNCYYRNPCNVSFEIEETAFLNLKNLTVLSLKSNNLTFIPPNLSSTLKELYIYNNRIQEVQEHDLSNLYNLEILDLSGNCPRCYNAPYPCTPCPNISIKIHSKAFYSLKKLRILRLHSNSLQSIPSSWFKNIKNLKNLDLSQNFLIKEIGDAEFLKLIPSLVELDLSFNFELQMYSPFLNLSKTFSCLSNLETLRIKGYVFKELREENLDPLLNLRNLTVLDLGTNFIKIADLRVFKKFRSLKIIDLSMNKISPSSGESNFYGFCSDHRITVEQYSRHVLQEMHYFRYDEYGRSCKSKDKEADSYQPLVNGDCMSYGETLDLSRNNIFFVNSIDFQDLSFLKCLNLSGNAISQTLNGSEFYYLSGLKYLDFSNNRIDLLYSTAFKELKFLEILDLSNNKHYFLAEGVSHVLSFMKNLAYLKKLMMNENEISTSISTGMESQSLQTLEFRGNRLDIFWSDGKKEYLSFFKNLTNLEQLDISPNMLNFLPPDVFEAMPPELKILNLTSNRLHTFNWGKLHLLTKLITLDLSNNLLTTVPRKLSNCTSTLQELILRNNRITRITKYFLRGAIQLTYLDLSSNKIQIIKKSSFPENIINNLRMLLLHNNPFKCNCDAVWFVGWINQTQVAIPLLATDVTCAGPGAHKGRSLVFLDLNTCELDTSYFIMYALSTSAVLCLMMFAVMSHLYFWDMWYSYHYCTAKLKGYRRIPLPDACYDAFIAYDNTDLAVNEWVMTELVEKLEDQKARQFNLCLEERDWLPGQPVFDNLSQSIQLSKKTIFVLTNKYIKSGTFKTTFYMAHQRLLDEKIDVIILIFLEKVLQKSRYVQLRKRLCRSSVLEWPTNPRSQPYFWQRLKNAIAMNNTLSYNKLLQETV
Protein: Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K) (Q8WYR1)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O02696}. Cytoplasm {ECO:0000250|UniProtKB:O02696}. Cell membrane {ECO:0000250|UniProtKB:O02696}; Peripheral membrane protein {ECO:0000250|UniProtKB:O02696}. Note=Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner. {ECO:0000250|UniProtKB:O02696}.
Interaction partners:
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Phosphatidylinositol 3-kinase regulatory subunit gamma
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphoinositide 3-kinase regulatory subunit 6
- RAC-alpha serine/threonine-protein kinase
- RAC-gamma serine/threonine-protein kinase
Sequence:
MQPGATTCTEDRIQHALERCLHGLSLSRRSTSWSAGLCLNCWSLQELVSRDPGHFLILLEQILQKTREVQEKGTYDLLTPLALLFYSTVLCTPHFPPDSDLLLKAASTYHRFLTWPVPYCSICQELLTFIDAELKAPGISYQRLVRAEQGLPIRSHRSSTVTVLLLNPVEVQAEFLAVANKLSTPGHSPHSAYTTLLLHAFQATFGAHCDVPGLHCRLQAKTLAELEDIFTETAEAQELASGIGDAAEARRWLRTKLQAVGEKAGFPGVLDTAKPGKLHTIPIPVARCYTYSWSQDSFDILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGHCAERDSLLSTSSLASHDSTLSLASSQASGPALSRHLLTSFVSGLSDGMDSGYVEDSEESSSEWPWRRGSQERRGHRRPGQKFIRIYKLFKSTSQLVLRRDSRSLEGSSDTALPLRRAGSLCSPLDEPVSPPSRAQRSRSLPQPKLGTQLPSWLLAPASRPQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRLENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDSPRHASPGELGTTPWEESTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVVKRQNSKSKKGFNQISTSQIKVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQAAPDLCSLLCLPIMTFSGALP
Protein: DNA repair protein RAD9 (P14737)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for cell cycle arrest at the G2 stage following DNA damage by X-irradiation or inactivation of DNA ligase.
Subcellular location: Nucleus.
Interaction partners:
- DNA replication regulator DPB11
- Serine/threonine-protein kinase CHK1
- Serine/threonine-protein kinase MEC1
- Serine/threonine-protein kinase RAD53
- DNA repair protein RAD1
- Serine/threonine-protein kinase TEL1
- Protein CRT10
- ATP-dependent helicase SGS1
- DNA damage checkpoint control protein RAD17
- Checkpoint protein RAD24
Sequence:
MSGQLVQWKSSPDRVTQSAIKEALHSPLADGDMNEMNVPVDPLENKVNSTNIIEGSPKANPNPVKFMNTSEIFQKSLGLLDESPRHDDELNIEVGDNDRPNANILHNERTPDLDRIANFFKSNRTPGKENLLTKYQSSDLEDTPLMLRKKMTFQTPTDPLEQKTFKKLKSDTGFCYYGEQNDGEENASLEVTEADATFVQMAERSADNYDCALEGIVTPKRYKDELSKSGGMQDERVQKTQIMISAESPNSISSYDKNKITGNGRTTRNVNKVFNNNEDNIGAIEEKNPVKKKSENYSSDDLRERNNQIIQSNESEEINELEKNLNVSGRENDVNNLDIDINSAVSGTPSRNNAEEEMYSSESVNNREPSKKWIFRYSKDKTENNSNRSTQIVNNPRTQEMPLDSISIDTQPLSKSFNTETNNELETQIIVSSLSQGISAQKGPVFHSTGQTEEIKTQIINSPEQNALNATFETPVTLSRINFEPILEVPETSSPSKNTMSKPSNSSPIPKEKDTFNIHEREVETNNVFSNDIQNSSNAATRDDIIIAGSSDFNEQKEITDRIYLQLSGKQISDSGSDETERMSPNELDTKKESTIMSEVELTQELPEVEEQQDLQTSPKKLVVEEETLMEIKKSKGNSLQLHDDNKECNSDKQDGTESLDVALIEHESKGQSSELQKNLMQLFPSESQEIIQNRRTIKRRQKDTIEIGEEEENRSTKTSPTKHLKRNSDLDAASIKREPSCSITIQTGETGSGKDSKEQSYVFPEGIRTADNSFLSKDDIIFGNAVWCQYTWNYKFYPGILLEVDTNQDGCWIYFETGRSLTKDEDIYYLDIRIGDAVTFDGNEYVVVGLECRSHDLNIIRCIRGYDTVHLKKKNASGLLGKRTLIKALSSISLDLSEWAKRAKIILEDNEKNKGDAYRYLRHPIRGRKSMTNVLSPKKHTDDEKDINTHTEVYNNEIESSSEKKEIVKKDSRDALAEHAGAPSLLFSSGEIRTGNVFDKCIFVLTSLFENREELRQTIESQGGTVIESGFSTLFNFTHPLAKSLVNKGNTDNIRELALKLAWKPHSLFADCRFACLITKRHLRSLKYLETLALGWPTLHWKFISACIEKKRIVPHLIYQYLLPSGESFRLSLDSPSKGGIIKSNNIFSFYTQFLRGSNLRDQICGVKKMLNDYIVIVWGRSELDSFVKFAFACLSAGRMLTIDLPNIDVDDTEPLLNALDSLVPRIGSELSNRKLKFLIYANENNGKSQMKLLERLRSQISLKFKKFNYIFHTESKEWLIQTIINEDTGFHDDITDNDIYNTISEVR
Protein: MIP06744p (C3KKC3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTSAVRAKSAAAAVGVAVDESSGSSNGSVADQEVASSKEAVLSVLIRKRYEKYVFAPWDDPIILIMEQLEHIEHCRSAALGNQVAIGRDPSQDDSLNDLGKVISNMRQDQSLVPIVKHIEQISDIQASNGQELASLGSLRELIRTIRKEWPRDDSIKLRLKEIQILGMPPARSLCFGERIRDDRCPLSLQTKRHKERIQAMMYERQPWRIRERMKTASVALVLCLNIGVDPPDVVKIQPCSRLECWIDPSSVSPPKAMELIGSNLQMQYERWQPRARYKKCNDPTVDDVKKLCTSLRRNAKGERILFHYNGHGVPKPTANGEIWVFNKTFTQYIPLSIFELITWMSAPSIYVYDCSNAGIIINSFQPYAKQHEEELGKALAAAQQRGGVQQLVGGSGGAANVAANQVQLTNQMVSYKNCIHLAACAANEILPMNAQLPADLFTSCLTTPINIALKWYAMQEKLGMVPRIQSELIDKIPGKVNDRRTMMGELNWIFTAITDTIAWNTLPRELFQRLFRQDLLVASLFRNFLLAERILRSHDCTPVSLPALPPCYRHPMWKAWDLVVDLALQQLPEILDHNAPYRQLPFFEHQLTAFQVWLDSESESRTPPEQLPIVLQVLLSQVHRLRALELLARFLDLGPWAVNLALGVGIFPYVLKLLQSSTRELRPVLVFIWAKILAVDPSCQVDLVKEYKYFLSVLQDTSVSKEHRTLSAFVLSSIVHNFLLGQTSALQGPLLSICLEQLNDGSWLLRQWLAICLGMLWQNFEKARWSGARDLAHEKLYVLLRDSIPEVRAAAVFALGTFISSVTDRSEEQANNIDRIIAITMLETVGEDMSPLVRMELAAALQWMVVLFESQFVAVYLTEHMRGHVSAASFVMCPDPRDLTSSTHSLERHVTIRRGASSSSISNMGGASISSGTGSSSNPLGRSKSGSGSSGGRGAAGAAGGTNSIPFQSIFTKLWLGICNLAQDPFPRVAAIAQEIVEHVRDTALCPIMAAKEATMANASEKCSSLSVSLPPSPNTRVNYLGGGGAPGGAGATAESPPVGAAASGASHWAQKLRLSGSGACMGAGDPQTILQRKLRTSSINDETDSGPGYSRGVAGAGTGLGLPSGPRESTHSARSSGSESNHYLEPGHSLTPIVLTEFIPWAISYFTRPGKERYSSAEGSAEEGRQRFPVDRNSAELRRRRLRFLRNDFVRRHAGRKHQELIDPYGFDVCVWNRKTQFTPSIVKLLPYEPQIAVAYREKVLVYDFQYNSVRTYGAESLGGNFTGYSSGYGSGSGSSSSLNGSTPRKSGAHTSGGGGGGFSAAPFARVSSIEFINAQDMALNLVAHEDGVVRVWQSSPPASSATSEDTPSKARLVTAWTALGQVNQHNHRQRSVASGGSIGKGADASGLSSAAIGSGGIVTAWQQCSQHLVIGGGGCRFIRIWDVERELKLADIPLGRSETCARVLSPYLPNMRSDVILAGCDDGSVRLFDKRCAPQDAGISAYRRHSAPILHASLRANGLVLVSGCTEGRISVADMRGSQSSINPFDVVYEWDAGGDVTAITSHQLEDTVACGNASKIVIYSLDGRQQKVLRTNEGFIGPKIGHPTYLYFHPYKAQLAVGFVDNTVAIYSPTPVL
Protein: Uncharacterized protein C6orf141 (Q5SZD1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNDPFARMETRGPQGAANPMDSSRSLGDLGPFPREVGRGAPLAPGARNPATAGASRSQGGGHEDRTADRALGPRAGEELDRESWVREKVLFLLHPERWLGTRGDPAREEVAGAEDLPHAGGEDHGEEPNYPSVFQRQKRISGRRVAPPRDAADPPKYVLVRVEDYQVTQEVLQTSWAKGRMTTRTEEHFVTALTFRSSREGQPGERWGPAESRALQARTGASRVHAAGRRVSPSPGTWLEEIKL
Protein: Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Q9VSI6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFALRRTAAMMTSVHRQPHLSQAVFRANFAISAAMAQKIKAGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDGQVIDEVINDFKGPGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLEGALAKNAVAAK
Protein: nitroreductase FRM2 (EC 1.7.1.9) (Fatty acid repression mutant protein 2) (P37261)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in negative regulation of fatty acid metabolism.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase II subunit RPB11
- Transcription elongation factor SPT5
- Mediator of RNA polymerase II transcription subunit 7
Sequence:
MSPTGNYLNAITNRRTIYNLKPELPQGVGLDDVKRTVHVILKNTPTAFNSQVNRAVIIVGDTHKRIWDAVASAMPTAEAKKRPESCRDEAYGSVIFFTDEGPTEKLQRDFPALAAAFPTCAAHTTGAVQIQSWTALELLGLGANLQHYNDYVKSALPQDVPIAWTVQSQLVFGVPTALPEEKTFINNVINVYH
Protein: ZAP3, isoform D (M9NF08)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWGQWQTAAAVAPTAALPPQPSVPPPLPDAPPPPPPSDATAGAGASSGASAPIVTTAAAVTTAPGFNPYSSGQATGAGNPYQQYTAAQYAAMTPEQQYALQHHWQQWQTYQEEYAKWHAQYGEQYKREMAAAAATTTAVQGVPAPVVATPAAAPVPVVAPPGPQAYPVAHNYYQGVSASPAQSTTPVAVAGAPPLPGKIMAQPQMYNQPPPPPQKGGYNQHPNDIQSMWSGPPPMQQPPPNRYGGGQMNQMNYNIAGQDNQGFPNLQQPPPSLQRPTPQQQQPHLNHMDHGQWGNNQHGVGNNNRPTWDTSGPPPDNTGQPNRWNGPPPANDVNNRWNGTSFNNNTNDGNRRWDGTSNQAPSGGDQQLNRWMSEPPPSLPNPNQQYQNQNSWMSGPPPSISDPPQDHQQQNNSSQNARSSRWQGINSDIDTPPMRTNNKPNSIQNSRNSWGDGGGDGNQSKNPFIKNPQSDFGNYGNSYNSQDQGSAGGGNFGGFGDDSGGKQSQDSFAGRGGGPGNNINNNFSNNRRQNNRRDNNRNQGFSDERGGGDSGPGGYNPNRGNYNQRNSFNQSNAPYKQSQQNRNQQQPPDLDEASFDLLFDQWEQQFEEWKLANANHPDRDEYRRYEEEFEKQRRRIAERREQMRRRRQLQMGGSAGGSTTDIRKEAAAGASTTAEQKPNKDPFEGQGRFADQGDQDHGSGPNFGNGNRQSGNAGHFGKENRPFESAGVPAFRGNQGPPPGMHNQYQTAQEAIQQILDEQPDESNQEIPTKPAASNENSSDVKKAKTTASPVAPPIAPVVPPEVKAPAAPVVPDPTVVPPTQPPPVSTNYGKRRQRAAPSQIPAKQVKEEEPIFTISLDDDDDDDEEKEVVQDAPNTPMGSIFKKNDGIPGLDLVDDGSNKNNSSSVFNVVLKDSSEKKAADETEKQPGDVSADKKGDESLSNALKDPNFINNLSQAVANVQEREQRDRHEQRDDQESGTDGRPLSFAEWQRKKNSGNENKSQDAGDSVSTNNGEKPDNNGPPGGFGPGNGPGGGPGSGPGQNDGSRFDVFGPNQVSGNNFIDLDNNGPPGFGPPGRNFGPNGPGPRGNFGPNFGHNFGPRGPGGPFIRPNGPLPGPGPNFGPHFRPNGPNFGPNFGPNFGPRPGSRNFGPRGPDGPFGPGRDDFGGPPFGGPRPHMGPNGPGHNMRGFNGGPISDNPFRRQGGPPGPGFGNDDLGAGPPRGPRNFGNRFGNPGGGGGGGGGGGNNNRKNWNDGTIMHAPTLAQQWENPRHSRMRLSRRQTTAIAPTLPTIAAS
Protein: Sideroflexin-5 (Q8TD22)
Organism: Homo sapiens (Human)
Function: Mitochondrial amino-acid transporter (By similarity). Transports citrate (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity). In brown adipose tissue, plays a role in the regulation of UCP1-dependent thermogenesis probably by supporting mitochondrial glycerol-3-phosphate utilization (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:30442778}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MADTATTASAAAASAASASSDAPPFQLGKPRFQQTSFYGRFRHFLDIIDPRTLFVTERRLREAVQLLEDYKHGTLRPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLIQRFVPFPAVASANICNVVLMRYGELEEGIDVLDSDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIAQATSSRTVVYNKGL
Protein: Class B acid phosphatase (CBAP) (EC 3.1.3.2) (P0AE22)
Organism: Escherichia coli (strain K12)
Function: Dephosphorylates several organic phosphate monoesters including 3'- and 5'-nucleotides, 2'-deoxy-5'-nucleotides, pNPP, phenyl phosphate, glycerol 2-phosphate, ribose 5-phosphate, O-phospho-L-amino acids and phytic acid, showing the highest activity with aryl phosphoesters (pNPP, phenyl phosphate and O-phospho-L-tyrosine), and to a lesser extent with 3'- and 5'-nucleotides. No activity toward ATP, phosphodiesters, glycerol-1-phosphate, glucose 1-phosphate, glucose 6-phosphate, NADP, GTP or 3',5'-cAMP, ADP or ATP. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds. Capable of transferring phosphate from either pNPP or UMP to adenosine or uridine. Does not exhibit nucleotide phosphomutase activity.
Subcellular location: Periplasm {ECO:0000269|PubMed:9011040}.
Interaction partners:
- 5-amino-6-
- NAD
- FMN reductase
- 5-amino-6-
- Riboflavin synthase
- Phytase AppA
- Bifunctional riboflavin kinase/FMN adenylyltransferase
Sequence:
MRKITQAISAVCLLFALNSSAVALASSPSPLNPGTNVARLAEQAPIHWVSVAQIENSLAGRPPMAVGFDIDDTVLFSSPGFWRGKKTFSPESEDYLKNPVFWEKMNNGWDEFSIPKEVARQLIDMHVRRGDAIFFVTGRSPTKTETVSKTLADNFHIPATNMNPVIFAGDKPGQNTKSQWLQDKNIRIFYGDSDNDITAARDVGARGIRILRASNSTYKPLPQAGAFGEEVIVNSEY
Protein: Large ribosomal subunit protein uL4 (60S ribosomal protein L4-B) (A0A1D8PFV1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:35613268}.
Interaction partners:
- Small ribosomal subunit protein eS24
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein uL29
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS30
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein uS13
Sequence:
MSSRPQVSVISVKGEQGSSQLPLPAVFAAPVRPDLVHSVFVRVNKNKRQAYAVAENAGHQTSAESWGTGRAVARIPRVGGGGTHRSGQAAFGNMCRGGRMFAPTKTWRRWNVKVNHNEKRYATASAIAASAVTSLVLARGHRVEQVKELPLVVSNEFESVTKTKDAVAVLKAVGAHKDVVKVIKSKKLRAGKGKLRGRRFTQRRGPLVVYAQDNGIVKALRNVPGVETASVKHLGLLQLAPGAHLGRFIIWTQGAFESLDSVYGSDSTKSIKSGYTLPSNIISNTDVTRLINSAEVQAVVRPAGEKTQKKSHVLKKNPLKNKQVLLRLNPYAKAYAAEKVGSAKVEQAKVKPSKGQFAEVLKN
Protein: FACT complex subunit POB3 (G0SHK5)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU364013}. Chromosome {ECO:0000256|RuleBase:RU364013}.
Interaction partners:
- FACT complex subunit
- RNA polymerase II-like protein
- Cell division control protein 73 C-terminal domain-containing protein
- Tetratricopeptide repeat protein 1
- RNA polymerase II-associated protein
- RNA polymerase-like protein
- Transcription elongation factor SPT5
- Transcription elongation factor Spt6
- Transcription elongation factor SPT4
- DNA-directed RNA polymerase subunit
Sequence:
MAAIESFDHIYLDLSKEPGKCRFAENGLGWKPVGGGETFTLDVSNIGGAQWSRAARGYEVKILQRTSGVIQLDGFQQEDYERLAKIFKNWYSTNLENKEHSLRGWNWGKAEFGKAELTFNVQNRPAFEIPYSEIANTNLAGRNEIAVEFAPGDHGKSSQNGQVKSKKASASRDQLVEIRFYIPGTTTRKEAEGGEAGSDADEEEKNAVTLFYDTLIEKAEIGETAGDTIATFLDVLHLTPRGRFDIDMYDTSFRLRGKTYDYKIQYEAIKKFMVLPKPDDLHFMLCIGLDPPLRQGQTRYPFIVMQFKQDEEVTLDLNLSEEELNGKYKDRLQAHYEQPAHQVVTYIFKGLANKKVTAPAKDFTTHRGHYGIKCSIKASEGFLYCLEKAFMFVPKPATYISYEQTQSVTFSRVGGAVSTLSTFDITVHMKNGQGSSQFSNINREELKALEDFFKLKGLKVKNEIDEDANLLAAALRDDDMASSDEDVVGGKADRGSADEDEESVDEDFQAESESEVAEEYDSQHESSGSGSDEDDDDLDDDVVDDDEDEEEEEEEEEEEEEERPKKKKKTG