wanglab/gogpt-training-data huggingface dataset:
Protein: Myb-like DNA-binding protein BAS1 (P22035)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Activates HIS4 transcription only in combination with PHO2/BAS2. BAS1 is also involved in the regulation of the purine biosynthesis pathway.
Subcellular location: Nucleus.
Interaction partners:
- Regulatory protein PHO2
- Adenylosuccinate lyase
- General control transcription factor GCN4
- Adenylosuccinate synthetase
- Serine hydroxymethyltransferase, cytosolic
- Phosphoribosylaminoimidazole carboxylase
- Bifunctional purine biosynthetic protein ADE5,7
- ATP phosphoribosyltransferase
- Amidophosphoribosyltransferase
- Transcriptional regulator MET31
Sequence:
MSNISTKDIRKSKPKRGSGFDLLEVTESLGYQTHRKNGRNSWSKDDDNMLRSLVNESAKELGYENGLEDVKTIQQSNHLSKCIAWDVLATRFKHTVRTSKDVRKRWTGSLDPNLKKGKWTQEEDEQLLKAYEEHGPHWLSISMDIPGRTEDQCAKRYIEVLGPGSKGRLREWTLEEDLNLISKVKAYGTKWRKISSEMEFRPSLTCRNRWRKIITMVVRGQASEVITKAIKENKNIDMTDGKLRQHPIADSDIRSDSTPNKEEQLQLSQQNNPSLIKQDILNVKENESSKLPRLKDNDGPILNDSKPQALPPLKEISAPPPIRMTQVGQTHTSGSIRSKVSLPIEGLSQMNKQSPGGISDSPQTSLPPAFNPASLDEHMMNSNSISDSPKHAYSTVKTREPNSSSTQWKFTLKDGQGLSISNGTIDSTKLVKELVDQAKKYSLKISIHQHIHNHYVTSTDHPVSSNTGLSNIGNINGNPLLMDSFPHMGRQLGNGLPGLNSNSDTFNPEYRTSLDNMDSDFLSRTPNYNAFSLEATSHNPADNANELGSQSNRETNSPSVFYPQANTLIPTNSTATNNEIIQGNVSANSMSPNFNGTNGKAPSSTASYTTSGSEMPPDVGPNRIAHFNYLPPTIRPHLGSSDATRGADLNKLLNPSPNSVRSNGSKTKKKEKRKSESSQHHSSSSVTTNKFNHIDQSEISRTTSRSDTPLRDEDGLDFWETLRSLATTNPNPPVEKSAENDGAKPQVVHQGIGSHTEDSSLGSHSGGYDFFNELLDKKADTLHNEAKKTSEHDMTSGGSTDNGSVLPLNPS
Protein: Guanylate cyclase (EC 4.6.1.2) (B3DHF2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Photoreceptor outer segment membrane {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004451}.
Interaction partners:
- Guanylate cyclase activator 1A.
- Phosphodiesterase
- Guanylate cyclase.
- Guanylate cyclase activator 1C
- Guanylate cyclase
- Guanylate cyclase-activating protein 2.
- Ectonucleotide pyrophosphatase/phosphodiesterase 1
- Bis
- Rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
- Inosine triphosphate pyrophosphatase
Sequence:
MRHIHLPFGGALWQFSSYPCCPVLRSRRSLSTLPFYSITLWIILGVLTFPRCVQCLVFKVGIIGPWNCDPNYAKSLPAIASRLAVGRINNDFSLDLGCTMDFVILQEACETSKALTSFVQYENVADAFVGPTNPGYCNAAALMSKNWDKSLFSWACVNHELDRVQGYPTFARTLPSPLRVLFNVLKFFRWANIGIVSSNEDIWIDTAAKLASALRNRGLPVGIVTSMGNNDTMLENTLMSIKNAGDIKVIIMCMHSVLIGGEQQATFLTKAYDMGLASGRYVFIPYDTLLYSLPYINITYYPLQNNSKLSKAYDAVLTITLDSDIMTFNEAFNAAKQLGELMVTQEPEQVSPLFGTIYNSLYLLAKSMHNARRAGRWLSGTNLAYFTRNITFTGFNQDIQTDEQGNGQTNYVILDTEAWGTQLYRCFLVDMTSDLVLFAGRFIHFPGESPPPSDSRCWFEDNAICTGGVDIIYVIIAFVIVLIIVLGSIGLSLFIRRRIQQIQLIKGPNRILLTLEDLTFINPQLSKRKITLEDLSDSKSYIEEKSTGDRSRSVNSMATATHETSNVAVYEGDWVWLKKFTEGHFKEVKQSTTKIFTKMKDLRNENVNPFLGFFTDCEMFAIVTEHCSRGSLHDLLRNDDVKLDWMFKSSLVLDLIKGMKYLHHREFPHGRLKSRNCVVDGRFVLKITDYGYNEILETQKAPKETLPPEDLFWTAPEHLRDPESPRKGTYKGDVYSFAIILQEVVVRGAPYCMLGLSPEEIIRKVKKPPPMCRPTVAPDQAPLECIQLMKQCWSEQPDRRPPFDQIFDQFKLINKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSVAEALKTGASVEPEYFDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLGSHDVYKVETIGDAYMVASGLPKKNGNKHAAEIANMSLNILSSVGSFKMRHMPEVPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNISTVQILRSLNDGYKIDVRGKTELKGKGIEETYWLVGKANFTKPLPNPPEIKPGDNWQDMMTEEIKSLFRKANRPVDKHKI
Protein: Calcitonin receptor (CT-R) (P30988)
Organism: Homo sapiens (Human)
Function: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
Subcellular location: Cell membrane {ECO:0000269|PubMed:35324283}; Multi-pass membrane protein {ECO:0000269|PubMed:35324283}.
Interaction partners:
- Calcitonin
- Islet amyloid polypeptide
- Receptor activity-modifying protein 2
- Receptor activity-modifying protein 1
- Receptor activity-modifying protein 3
- Pro-adrenomedullin
- Guanine nucleotide-binding protein G
- Calcitonin gene-related peptide 2
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQELRNEPANNQGEESAEIIPLNIIEQESSA
Protein: DSC E3 ubiquitin ligase complex subunit 1 (EC 2.3.2.27) (Defective for SREBP cleavage protein 1) (RING-type E3 ubiquitin transferase DSC1) (O43085)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Interaction partners:
- DSC E3 ubiquitin ligase complex subunit 2
- DSC E3 ubiquitin ligase complex subunit 3
- UBX domain-containing protein 10
- DSC E3 ubiquitin ligase complex subunit 4
- Cell division cycle-related protein res2/pct1
- Start control protein cdc10
- Cell division cycle-related protein res1/sct1
- UBX domain-containing protein 2
Sequence:
MDRRRWVPSTPVVTLLLLFMLFAPAPRLPSRNGESSEKSIKAEKRAFSEIKNATFLNIPERVEHSLTFPTEIWETRDGLFEEPVGKGDSHLNHTSVMTGNWNILPYPSFGKVSPNVTWHTTLRNIVMSQSGRFSANLYEYVDGNSDGISFVLNLENNNDTSVYHMTFHGDRVKPINVFLGSTDVTPNFGGVDVIPWLLKDSPYKDAPPLDGTEYFPLLQNRSLERIETRLQDAQTVGWSPLVFEEEEVTCSAFVFLHNKNTGLDKETLKAIENEFYHPQGVSTQKMPEVFVSGLVYSPDCNVAFTFSNTKGPRNFVLENHLVRFSSLYIFIVLSQIFVLLRQMRINSPSHVQRLSFLTIAMQAGLDAYIAIFFLSTNAVIEKGYLPFVSVAFLSLVPSVMFTMRYLALILRVQNSNMPPPAPRPVTNNSSNNNTNQSNASNENSPNAPSAANDNTETTTVNPPQEDDQPMTQHERDQRDWSAVCLRFYFIILVVCIASLYSAFWPVIYRFYFISALIFTSYSFWIPQIIQNVKQGTSRSFTWTYILGASVLRLYLPLAIFIDSELILGFPPKYFFALGLVLWMLFQVLVLLVQDTLGPRFFLPKKFFLSSPVYDYHPVIQQDDLEAFMRDANVCPICMQPIELVSTGSTLNPASMMVRRNYMLTPCHHLYHRQCLLQWMETRSICPVCRCHLPAV
Protein: G protein-coupled receptor kinase 1b (O95098)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
KLRAHPLFKDLNWRQLEAGTVGRLSPGEGGVLCCVALGCPPGPACESRQGGVPQTPKALPLPPARPPVLHSSSQPQDKPMEPASGQRALGAMGGRKHTGRTGASRPKPSTTSPGAGGSPRSNGGQWLRPSAGEKVIHPPALA
Protein: Rpgrip1-like (D3Z8G3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
- Nephrocystin 4
- Nephrocystin-1
- Centrosomal protein 290
- X-linked retinitis pigmentosa GTPase regulator
- Meckelin
- Coiled-coil and C2 domain containing 2A
- Nephrocystin-3
- Jouberin
- Transmembrane protein 216
- IQ calmodulin-binding motif-containing protein 1
Sequence:
MSGPSDETAGDLPVKDTGLHLFGIGGLQETSTARTVKARQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELERQNEVLKNRLISAKQQLQVQGHRQTSYSRVQARTNTGRRKASTTAGLQECLGKGIKVQNVDEAETVQPTLTKYSSGLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLKRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSVIEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSVRFSERRVEELQDRINDLEKERELLKENYDKLYNSAFSAAHEEQWKLKEQQMKVQIAQLETALKSDLTDKAEVLDQLKTERGPLINQNEKLVQENRDLQLQCLQQKQQLHELQNRMKFFNQESDINVDDLSEALLLIKAQKEQKNGDLSFLEKVDSKINKDLDRSMKELQATHAETVQELEKTRNMLIMQHKINKDYQMEVETVTQKMENLQQDHELKVEQYVHLLDVRAARIQKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVAFASDVLRASGDKELLTFCTYAFYDFELQTTPIVRGPCPEYNFTSQYLVHVNDLFLQYIQKNTVTLELHQAYSTDYETVAACQLRFHEILEKSGRIFCTTSLVGTKGDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKKPEKMQLLSQQAATTAQISSPESTDGNLNELHITVRCCTNLQSRARHLQPHAYVVYKFFDFPDHDTAIIPSSNDPQFDDYMCFPVPMNMDLDRYLKSESLSFYVFDDSDIQENIYIGKVNVPLISLAHDRCISGIFELMDKDKHAAGTIQVILKWKFTYLPPSGSIPTEDLGRFVGREEPEAIQRRPPTSSGTEAVVTPKPKPRQRLTFVDKKVSFVDTMPHPSPEASPPPKDIKHNSPEVGPETENSMPAVACPSKESSVAKVEENMGKTQQGKEDDISFLSEGQLASQSVASSEDETEITEELEPEDEDRSASDSDDCIIPSSVSTDTKKPSEEIRIEIIALSLNDSQITREDTVQRLFIECRFYSLPAEETPMSLPKPKSGQWVYYNYTHVLYLDKENNPAVRDVLKAVLQRRELPHRSVRFTVVSDPPEDEQDLECEDIGVAHLDLVDVFQKGRDIIEQDIDVLDARTDGGSIGKLKVTVEALHALRSVYEQYRKDLEA
Protein: At3g10570 (Cytochrome P450, family 77, subfamily A, polypeptide 6) (Cytochrome P450, putative) (Putative cytochrome P450; 45201-43660) (Q9SQY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein HOTHEAD
- Cytochrome P450 704B1
- Glycerol-3-phosphate 2-O-acyltransferase 6
- F21B7.2
- Fatty alcohol:caffeoyl-CoA acyltransferase
- Omega-hydroxypalmitate O-feruloyl transferase
- Cytochrome P450 86A7
- Cytochrome P450 86A4
- BAHD acyltransferase DCR
- Cytochrome P450 86A1
Sequence:
MSILSFPHTFFNISPSLFYTILISSLVLLILTRRSAKSKIVKLPPGPPGWPVVGNLFQFARSGKQFYEYVDDVRKKYGPIYTLRMGSRTMIIISDSALVHDVLIQRGPMFATRPTENPTRTIFSSNTFTVNASAYGPVWRSLRKNMVQNMLSSIRFREFGSLRQSAMDKLVERIKSEAKDNDGLVWVLRNARFAAFCILLEMCFGIEMDEESILNMDQVMKKVLITLNPRLDDYLPILAPFYSKERARALEVRCEQVDFIVKLIERRRRAIQKPGTDKTASSFSYLDTLFDLKTEGRITTPSNEELVSLCSEFLNGGTDTTGTAIEWGIAQLIVNPEIQSRLYDEIKSTVGDREVEEKDVDKMVFLQAVVKEILRKHPPTYFTLTHSVTEPTTVAGYDVPVGINVEFYLPGINEDPKLWSDPKKFNPDRFISGKEEADITGVTGVKMMPFGIGRRICPGLAMATVHVHLMLAKMVQEFEWSAYPPESEIDFAGKLEFTVVMKKPLRAMVKPRV
Protein: Ras-related protein RABE1c (AtRABE1c) (Ras-related protein Ara-3) (Ras-related protein Rab8A) (AtRab8A) (P28186)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in membrane trafficking from the Golgi to the plasma membrane.
Subcellular location: Golgi apparatus membrane. Cell membrane {ECO:0000269|PubMed:15060130}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Peroxisome biogenesis protein 7
- Putative RRM-containing protein family protein)
- At4g25660
- Uncharacterized protein F9K21.80
- Reverse transcriptase-like protein
- Hydroxyproline O-arabinosyltransferase 3
- Arabinosyltransferase RRA1
- Putative RING zinc finger protein; 84572-85321
- Arabinosyltransferase XEG113
- At5g58750
Sequence:
MAAPPARARADYDYLIKLLLIGDSGVGKSCLLLRFSDGSFTTSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDESSFNNIRNWIRNIEQHASDNVNKILVGNKADMDESKRAVPTAKGQALADEYGIKFFETSAKTNLNVEEVFFSIGRDIKQRLSDTDSRAEPATIKISQTDQAAGAGQATQKSACCGT
Protein: Scavenger receptor class B member 1 (SRB1) (SR-BI) (Q61009)
Organism: Mus musculus (Mouse)
Function: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (By similarity). Both isoform 1 and isoform 2 act as receptors for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:9254074, ECO:0000269|PubMed:9614139}; Multi-pass membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000269|PubMed:9614139}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:9614139}. Membrane, caveola {ECO:0000269|PubMed:9614139}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:9614139}. Membrane, caveola {ECO:0000269|PubMed:9614139}.
Interaction partners:
- Apolipoprotein A-I
- Toll-like receptor 4
- Apolipoprotein B-100
- Toll-like receptor 2
- Thrombospondin-1
- Leukocyte surface antigen CD47
- Toll-like receptor 6
- CD81 antigen
- Integrin beta-1
- Tyrosine-protein kinase Lyn
Sequence:
MGGSSRARWVALGLGALGLLFAALGVVMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQVLHYAQYVLLGLGGLLLLVPIICQLRSQEKCFLFWSGSKKGSQDKEAIQAYSESLMSPAAKGTVLQEAKL
Protein: Integrator complex subunit 5 (A0A0R4IY96)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Integrator complex subunit 1
- Integrator complex subunit 8
- Integrator complex subunit 4
- Integrator complex subunit 9
- Integrator complex subunit 11
- Integrator complex subunit 12
- Integrator complex subunit 7
- Integrator complex subunit 2
- Integrator complex subunit 3
- Integrator complex subunit 13.
Sequence:
MSGMFEGNALPGIQTHSHTPNNYSPQELSLEIKAFISGVDQTQGRKLSVRDHARCAIRLLRTVPACREAVLEHLRGVYDEYVASFLQDLEAEGENGGNSASGGASVSISNLEDVIKEVHAVLSEFIKLSPKAWAPLVSSWAVDLLGQLSSKHAGRRAAPHSSSLNELLQLWMSCAATRSLMECYSQCLAAMLAWCPDACVDALLDTSVQHSPHFDWVVAHIGSAFPGTIISRVLACGLKDFYAHGYSSAEKISQQQAIDKSSRVPKIGSVVGILGHLASRHSDSIKKELLRMFQDSLSVPPQNVPQLTSGAGGWENSPHLRRATVPFLLQLAALSPTLLGAVSTELVEFLRPPVLIQLQAQFQALPREELENMLGLAVHLISQSPSGGARVLKFLADTATPSSVIISGPTPSPHDGIREACDRLLQMLLLHLHKLVHNRPDGDEPFPQSSTSPAMPQVIPFLEELQAHIADLCAETLRLERKRHLWLHQLLCLLSVYGGPSIATEALCQLFTQARNPEELALASQLYTQLSTSLSGLLPSTVARCVAQIHTQTLDIKELAQLLNNLATAVQSQEEDGKNGGGTTTTTGSLTQSSMASEVRVAVSSNLQDFCPLLLHGDSGVSKAAVRLLSCSQIPRACSPAHLLRICRAAVSHFFVCLRQQGKSPQAGQEEVGYSRRLLSRLAAYSSLSQKAVLQQLVEGALHKGNQDLFGGLQENPSDDTTQAQNLVPDLGISLLDVNRKFGTSVNFSGNVWSVFHAGIIGKGLKPPYTPLHPDPDRVSQNMQTLLAVMVQCCSSSGGNPTGSAGSTCSEPNVSDKLPPINAEAAKVIAVTLVENICPDVANGELSWPPEEHSKTTVERDIHIRRCFEKNPVLFYLLHVVAAGRPALCYCSVILRALLSTLLAHWESSREPSVSDSPWHLQTSCWLVSCMGEGQLLPPVLSNINEVFPHLSPFEVRLLLLGVWEYMRGNSPMPQKFTFCADQGLFFRDFSRDGDVARYIAPIHSVLHKNIDRLGHLCWRFQV
Protein: ER membrane protein complex subunit 3 (Q38BC5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 7 beta-sandwich domain-containing protein
- MPN domain-containing protein
Sequence:
MTQNILLDPSIRDWVLFPLIALVIFVGILKHYASILMKTSASPKMETMCCANTVNCARHLLSEGRKLPSEAFQQRVKALREGPLKKKIEVNPMEIMNDPTVLGDMMKGNVLSMLPSMGMMMLVSYFFSGFVVAKFPFVLASRFRGMMQRGVEIDDLDCNYVTSLSMYFLIMFGSNSVLQLLLGEGGIPDENAMMMNSMSGGGPQQPVDYNKVFKSLSDELEYAQDKHRWVYGDAPRLLLEGK
Protein: I[[h]] channel, isoform F (B7YZE7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MHVKHTQRRVSGPGAFGTFTNDQRASRDNLCPDNQQQQQQRHSHSHQHLVRQSLVSLSNGQPAASAAPDSVSLLRAGDDQQQHPQQPHLQQQQQQQQHLQQQQQRHRSSSSRLSTSGISKQNSSDSRSGLRILDSSHSPVSCGTQSVSSTGGQSALYDACHEYSRSLSAAAAEGAASLLKSHYSDQQLAQTEPDPEPDPERDRDRDRDRDRDRERERRHLTNLNLNLSSEYDYSGSDKQQLVNETYIFKCIANSPSFLRTNKIKEQSKKLRNLSLKTRTAKKKGQIISKSNAVSDNSLHPGDKYLNLYLVEKKHSLQPQVASTSSSINTTHPQASSAPASSSSTCTKAPQLPALSAVAARQQQLLLNGSLKGKGQSQSQGQSRQTLPGHRASVRSESGSGSSHTIPATGKSPPVPHSLAAKISSSASGSKNCNLLSASSNSCHKLNAHAQGSGAGSGSGSGSGSGPPGHSHYAAASPKSSVSSNGHLNKYCLTDLTRRKAEFNRQLSAPTDYTHHSSSNGSQQEGSSEANEGHEPVGESTITVASAGVSYPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAAEADDCKDDDMDLKENLLHGSESSIAEPVQTIREGLPRPRSGEFRALFEGNTP
Protein: STE20-related kinase adapter protein strd-1 (STRAD STE20-related adapter homolog) (G5ECN5)
Organism: Caenorhabditis elegans
Function: Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses. Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4. May be involved in maintaining the integrity of the early embryonic cortex when bound to par-4.
Subcellular location: Perikaryon {ECO:0000269|PubMed:20023164}. Nucleus {ECO:0000269|PubMed:20023164}. Cell projection, dendrite {ECO:0000269|PubMed:20023164}. Cell projection, axon {ECO:0000269|PubMed:20023164}. Synapse {ECO:0000269|PubMed:20023164}. Cytoplasm, cell cortex {ECO:0000269|PubMed:20110331}. Cytoplasm {ECO:0000269|PubMed:20110331}. Note=Localizes in punctate structures along the neurites of GABAergic motoneurons. Co-localizes with sad-1 at synapses (PubMed:20023164). Co-localizes with par-4 at the cell cortex of the early embryo. Cell cortex localization is regulated by par-4 (PubMed:20110331). {ECO:0000269|PubMed:20023164, ECO:0000269|PubMed:20110331}.
Interaction partners:
- Serine/threonine-protein kinase par-4
- MO25-like protein 2
- MO25 homolog
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- J domain-containing protein
- Protein transport protein Sec61 subunit gamma
- Translocation protein SEC62
- MO25-like protein 3
- Protein transport protein Sec61 subunit beta
Sequence:
MADTTILDTTCSSTLAANVEFSHATDSAIGISLKNATITEAEGVPNLKETGYDCVRYMGTCNGGQIYLGRERKKLKDYVAIKKFAIDDVDDYAAIAKESSNLRLMHHPNIIELCECFVYERSIYQITPAMNLGSLFDIVFEYMKWGINEKSAAAITRQLLDALSYLHQRRYIHRDLKPKHILIDSSGNVKLSGFRFMIELNHHLDCVFEFDAHLQNQLYYLAPEVLAQNIHGYTSKSDIYMLGISICEAINGVMPFGELEPLEMLHRKLNGQVPRPVDMISLKDDQKMGLDISHRPQEHLTRRFSKEMHEFIANCLDYDPQQRGSASDLKSSAWLGSKIHKNLGPVDVRQELNLDYAHFDLSLWEQEPLIPMEPDQKYEIVFDYSPIS
Protein: F-box and leucine-rich repeat protein 7 (LD38495p) (Q9VF10)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Cullin homolog 1
- GEO01111p1
- SH3 domain-containing protein Dlish
- RING-box protein 1A
- Discs overgrown protein kinase
- Aurora kinase
- Extracellular serine/threonine protein kinase four-jointed
- Dachs, isoform E
- F-box only protein 9
Sequence:
MSHKTSNRRSSDLECPLASLGRNSNAVRDHYHHPHPLSSSPLDPQAYKMMSRKSPNPGLEVAEALASRSSTPPSDQAGASSTAAAAAVLHMVQQKAATFELRGRHSRPTEQQTSYGAHSTASVGRHAKKSPELPAPASRNVAPVPQPRNFLTLEHVLQFGTQRPSWMHGNSADTEDSSDNNAGGGGAGSGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRTLPLGAEASQFQNERYYLEDYSSGSGNERLPERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCNLGRFSPSLDQGYATLVSPSPTGHHSSGGAGNVTNSTTASGAGIMASSTPTTTPRRGASSNGLGGGAASAIGPPPWNRKGPFRCGPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCRISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEPPRRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIGKCDVSDAGLRALAESCPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQDCPVSIEGYRAVKKYCKRCIIEHTNPGFC
Protein: HY5-homolog (A8MS70)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSLQRPNGNSSSSSSHKKHKTAGSTCVLSSSADDGVNNPELDQTQNGVSTAKRRRGRNPVDKEYRSLKRLLRNRVSAQQARERKKVYVSDLESRANELQNNNDQLEEKISTLTNENTMLRKMLINTRPKTDDNH
Protein: Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (Anaerobically induced protein 1) (Hypusine-containing protein HP1) (eIF-4D) (P19211)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Essential for polarized growth, a process necessary for G1/S transition. May mediate large range of effects of the polyamine spermidine in the cell (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P23301}. Note=Concentrates in the perinuclear region. {ECO:0000250|UniProtKB:P23301}.
Interaction partners:
- Deoxyhypusine synthase
- Deoxyhypusine hydroxylase
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein bL28m
Sequence:
MSDEEHTFENADAGASATYPMQCSALRKNGFVVIKGRPCKIVDMSTSKTGKHGHAKVHLVTLDIFTGKKLEDLSPSTHNLEVPFVKRSEYQLLDIDDGYLSLMTMDGETKDDVKAPEGELGDSMQAAFDEGKDLMVTIISAMGEEAAISFKEAPRSD
Protein: Poly(rC) binding protein 2 (A0A0G2KBC5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDTGVIEGGLNVTLTIRLLMHGKVRISLENWKGESVKKMREESGARINISEGNCPERIITLAGPTNAIFKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGIPQSIIECVKQICVVMLEVSPQSPPKGVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVREAEIGGPLYSLRLG
Protein: Signal transducer and activator of transcription (X2KN52)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
Sequence:
MAQWEKLRQLDSVYLTQVDELYDGDAFPMDVRHYLAHWIEGQDWDRAARDHDVAMVLFQVLLENLDIQHSRFVQGGESFLLQHNIRRFKHSFQRYQEEPYNLANIIQWFLEKEKEILQNAELAEQVQLLQVQQNPMETDSQRNIERKMADVKNKVQCMEHTVKCLEEQQDEFDFKYQTHNMEGTTNEAEKTEQMKVLQALLNRLDASRKSMLSGMSVLLDVAEDLLCVLVREELVQWQRRQQKACIGAPDSTCLDQLEKWFTTEAECLFQVRKFLKKLEELMGKVTYEHDPVKKQKPALQKRVDSLLTSLLKSAFVVETQPSMPQGKGPLVLRTNVQFSVKTRFLVKFPELNHAMKVNVSMDREAPLVKGYRRFNVLGTNSKALNMAESMSGGMVADFRHLTLKEQKSGGGGKGIHDLSLSVTEELHIINFNTEFLLHDMSVSLETSSLPVVIISNSSQQQSAWASILWFNMLCLEPKNLLFFANCPAATWPQLGEMLSWQFLSSTTRGLEANQLDMIAHKLFGKQQSYDACKISWTKFSKENVPNTNFTFWVWFDGILFMVKTHLENLWKDGSIMGFVSKGKEKTLLKKKRRGTFLLRFSESIRDGGITFSWVDYSPTGEPDVRSVQPFTKVDLCQIPFHEIIRNFQILEEENVPENPLLFLYPDTPKVEAFGKYYTEKSGADSQFFKYIRTKLVFVSKENTLEAKSLMYSDTVEGEGSGPMNPRYGLGGEAVEPSTFLPLPPSPDPMFPDAMVNPDEDLNPTFQEFLDDQSIYDCGDFLSDDTTFLEGALPGLPFTALLQPCE
Protein: Probable WRKY transcription factor 38 (WRKY DNA-binding protein 38) (Q8GWF1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable WRKY transcription factor 40
- Histone deacetylase 19
- Protein NIM1-INTERACTING 1
- Probable WRKY transcription factor 59
- Regulatory protein NPR1
- Isochorismate synthase 1, chloroplastic
- Pathogenesis-related protein 5
- Probable WRKY transcription factor 70
- Histone deacetylase 6
Sequence:
MEMNSPHEKAVQAIRYGHSCAMRLKRRLNHPMADGGPLSSYDLAKSIVESFSNAISILSAKPETEDDQFSDLSSRDSSPPPQGSPSKKRKIDSTNSSENWRDDSPDPIYYDGYLWRKYGQKSIKKSNHQRSYYRCSYNKDHNCEARKHEQKIKDNPPVYRTTYFGHHTCKTEHNLDAIFIAGQDPLDDFKSTQMIRFGKDQDQEKESRSNGFSLSVKHEEDIIKEQAIDQYREITSNDQDCQDVIEEYLSSPSGSYPPSSSSGSESADFNSDLLFDNPDSWDRYDQFYF