wanglab/gogpt-training-data huggingface dataset:
Protein: Free fatty acid receptor 3 (G-protein coupled receptor 41) (Q3UFD7)
Organism: Mus musculus (Mouse)
Function: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Exhibits an SCFA-independent constitutive G protein-coupled receptor activity.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Olfactory receptor 51E2
- Free fatty acid receptor 4
- Peptide YY
- G-protein coupled receptor 84
- Delta-1-pyrroline-5-carboxylate synthase
- Pro-glucagon
Sequence:
MGTSFFLGNYWLFFSVYLLVFLVGLPLNVMALVVFVGKLRRRPVAVDLLLLNLTISDLLLLLFLPFRMVEAACGMRWLLPFIFCPLSGFLFFTTIYLTSLFLTAVSIERFLSVAYPLWYKTRPRLAQAGLVSVVCWFLASAHCSVVYITEYWGNATYSQGTNGTCYLEFREDQLAILLPVRLEMAVVLFMVPLCITSYCYSRLVWILSRGASRRRRKRIMGLLAATLLIFFVCFGPYNMSHVVGYVSRESPSWRSYVLLLSTLNSCIDPLVFYFSSSKFQADFHQLLGRLLRTCVPWTQQVSLELKVKNGEEPSKECPS
Protein: Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s) (Q96KK5)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
Sequence:
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAK
Protein: Vomeronasal 2, receptor 120 (A0A3Q4L2R4)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLIFVSVLLFLNFPVASCEPINPGCSLGMADAIFQDGDVLVDCHFVLLTVSIALQKIFHFLRFHLSFPMFIYRIHPNKYQYVIALNFAIEEINKNIHLLPNISLGYDMYSIVQYQATILEHSIRFLTGLKEAIPNYTCRKESKLIAVVTGTSWEFPSRISTILGLYKYPQNPLGLFEIYGIVFFTSLHIFFSHQLTFGPFDPMLSDHVKFPFIYQMAPEDTSLALGMVSLMVHFSWTWVGLIITENEKGIKFLSDLKREMKKNSVCAAFVQMLSLKYRYNWNDLLSTDPAIMGEMLHPFLKNIQFNNPSGDKVDLSHTGKLETKYDIFNFWNFPQGLGLKVKVGTFSSFLPRNKQFSLSDGMIEWGTKDKQTVFSV
Protein: Epididymis secretory sperm binding protein (A0A384NYW3)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNCREPGDIFSELKIL
Protein: Putative complexin-1 (Q9GUM7)
Organism: Caenorhabditis elegans
Function: Positively regulates a late step in synaptic vesicle exocytosis.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}.
Interaction partners:
- Rab-3-interacting molecule unc-10
- Acetylcholine regulator unc-18
- Syntaxin-1A homolog
- Synaptosomal-associated protein
- Lethal giant larvae homologue 2 domain-containing protein
- Phorbol ester/diacylglycerol-binding protein unc-13
- Synaptotagmin-1
- Synaptobrevin-1
- Ras-related protein Rab-3
Sequence:
MAGFLMKQMVGNQLSEVTGGLGMKDDGGEKTETGEDPEVIAARLEQEERRKEKHRKMENEREKMRQGIRDKYAIKKKEEGVAMDFTEGRIGGPRKTPEEIAAEMNAEDDSLIGQLGLTEQVEKAKTMATGAFETVKGFFPFGK
Protein: CREB3 regulatory factor (Luman recruitment factor) (LRF) (Q8IUR6)
Organism: Homo sapiens (Human)
Function: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
Subcellular location: Nucleus {ECO:0000269|PubMed:18391022}. Note=Colocalizes with CREB3 in nuclear foci.
Interaction partners:
- Cyclic AMP-responsive element-binding protein 3
- Kelch-like protein 24
- Cyclic AMP-responsive element-binding protein 3-like protein 4
- cAMP-responsive element-binding protein-like 2
Sequence:
MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFLSLEDCKDIENLESFTDVLDNEGALTSNWEQWDTYCEDLTKYTKLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSLFSVKQNPLPSSFPGKKITSRAAAPVCSSKTLQAEVPLSDCVQKASKPTSSTQIMVKTNMYHNEKVNFHVECKDYVKKAKVKINPVQQSRPLLSQIHTDAAKENTCYCGAVAKRQEKKGMEPLQGHATPALPFKETQELLLSPLPQEGPGSLAAGESSSLSASTSVSDSSQKKEEHNYSLFVSDNLGEQPTKCSPEEDEEDEEDVDDEDHDEGFGSEHELSENEEEEEEEEDYEDDKDDDISDTFSEPGYENDSVEDLKEVTSISSRKRGKRRYFWEYSEQLTPSQQERMLRPSEWNRDTLPSNMYQKNGLHHGKYAVKKSRRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLNTEYDNLLFVINSIKQEIVNRVQNPRDERGPNMGQKLEILIKDTLGLPVAGQTSEFVNQVLEKTAEGNPTGGLVGLRIPTSKV
Protein: Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) (P56926)
Organism: Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00126}.
Interaction partners:
- Proline--tRNA ligase
- Aspartyl/glutamyl-tRNA
- Glutamyl-tRNA
- Glutamyl-tRNA
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein uL15
Sequence:
MGAFGWEQDRGAPFSGRSPRILTRMTDAPRPTAGADAPARPPAAPLVAPNFITEIIERDLEAGKYPRVVTRFPPDPSGYAHLGHVFASLLDFNTARQYGGQFNLRMDDTNPELARQEYVDSIADDLKWLGLDWGEHFYYASDYFDRYYAYAEQLIRQGDAYVESVSPEELSRLRGNATTPGTPSPYRDRSVEENLDLLRRMKAGEFADGEHVLRAKIDLTAPNMKLRDPVLYRIVNKPHFRTSDEWHIYPAYDFEHPLQDAIEGVTHSMCSLEFVDNRAIYDWLMEKLNFDPRPHQYEFGRRGLEYTITSKRKLRELVQAGRVSGWDDPRMPTLRAQRRLGVTPEAVRAFAAQIGVSRTNRTVDIAVYENAVRDDLNHRAPRVMAVLDPVKVTLTNLDGEKTLSLPYWPHDVVRDSPDGLVGMPGGGRVAPEEAVRDVPLTRELYIERDDFSPAPPKGFKRLTPGGTVRLRGAGIIRADDFGTDEAGQVTHIRATLLGEDAKAAGVIHWVSAERALPAEFRLYDRLFRVPHPEGENADVEDDSAGPAEHEAEPGAGQETAPVSQGFMRYLTPDSLRVLRGYVEPSVAGDPADTRYQFERQGYFWRDPVELERVDSREDALVFGRIITLKDTWGKQGGGTQQKAEGKKRPSTKGRGPDEVRGEGSSSPAKAHAPKAQPLTPEQDAEFTRLLGLGASEGDARTIARDPALLAFVGGAAPGDTFAQVASWTVNELVAGLRAGEVKVRAADLAPLAEGVASGQLSARIAREALARAAASGDAPLTIIEREGLNAGLSAEALQQVVAQVIAANPDKAEAYRGGKTALLGFFTGQVMRATAGKADPQALAAALKDALA
Protein: Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) (Q00536)
Organism: Homo sapiens (Human)
Function: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22798068}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q63686}. Cell membrane {ECO:0000269|PubMed:22184064}; Peripheral membrane protein {ECO:0000269|PubMed:22184064}; Cytoplasmic side {ECO:0000269|PubMed:22184064}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q63686}. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.
Interaction partners:
- Cyclin-Y
- Cyclin-Y-like protein 1
- Tudor domain-containing protein 7
Sequence:
MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF
Protein: Non-structural protein 1 (NS1) (Q194T2)
Organism: Influenza A virus (A/WSN/1933(H1N1))
Subcellular location: Host nucleus {ECO:0000256|RuleBase:RU362113}. Host cytoplasm {ECO:0000256|RuleBase:RU362113}.
Interaction partners:
Sequence:
MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV
Protein: CAlcium channel Localization Factor (Q9XVF6)
Organism: Caenorhabditis elegans
Interaction partners:
- Voltage-dependent calcium channel type A subunit alpha-1
- Voltage-dependent calcium channel unc-36
- BK channel Interacting Protein
- Caveolin-2
Sequence:
MSSPQQFTIPASEVMTSIVLPTIIFCVGLVAAMLLGINKCKQWELDKVVEMRRSRRVLQRVTNRLREKNFKTIQRARTMRKRAASAKARNEFSPPAYQSKNNSTEFPCGTSPPPSYEDDVLEEYYKECHPSRRSIPVPSSPRRYIRQRSKFSSAARRVSRSSVSTGCHQPRGSIHIV
Protein: Dephosphocoenzyme A carrier, isoform A (Dephosphocoenzyme A carrier, isoform C) (Dephosphocoenzyme A carrier, isoform F) (RE52377p) (Q9VDL7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- Large ribosomal subunit protein eL18
Sequence:
MSRLLEKPNIAMSIKSTGSQLSSTMTTASATLSSDLDDADTSRTQLSPSETSGVVLVPATTVTPMRQKIDQVVISLISGAAAGALAKTVIAPLDRTKINFQIRNDVPFSFRASLRYLQNTYANEGVLALWRGNSATMARIVPYAAIQFTAHEQWRRILHVDKDGTNTKGRRFLAGSLAGITSQSLTYPLDLARARMAVTDRYTGYRTLRQVFTKIWVEEGPRTLFRGYWATVLGVIPYAGTSFFTYETLKREYYEVVGNNKPNTLVSLAFGAAAGAAGQTASYPLDIVRRRMQTMRVNTAGGDRYPTILETLVKIYREEGVKNGFYKGLSMNWIKGPIAVGISFSTYDLIKAWLTELANLRRVEK
Protein: Tlo16p (A0A1D8PRM3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MPENLQTRLHNSLDEILKSSGYIFEVIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKEEAARKKEEGAKKKEEEAKKKAEEAKKCFILLFCQICTTFNLCANILFYLIFIYFYFTILFYRTFYIFSLSTVRYRVGLPS
Protein: Receptor-like protein Cf-9 (Q40235)
Organism: Solanum pimpinellifolium (Currant tomato) (Lycopersicon pimpinellifolium)
Function: Involved in plant defense. Confers resistance to the fungal pathogen C.fulvum through recognition of the AVR9 elicitor protein.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDCVKLVFLMLYTFLCQLALSSSLPHLCPEDQALSLLQFKNMFTINPNASDYCYDIRTYVDIQSYPRTLSWNKSTSCCSWDGVHCDETTGQVIALDLRCSQLQGKFHSNSSLFQLSNLKRLDLSFNNFTGSLISPKFGEFSNLTHLDLSHSSFTGLIPSEICHLSKLHVLRICDQYGLSLVPYNFELLLKNLTQLRELNLESVNISSTIPSNFSSHLTTLQLSGTELHGILPERVFHLSNLQSLHLSVNPQLTVRFPTTKWNSSASLMTLYVDSVNIADRIPKSFSHLTSLHELYMGRCNLSGPIPKPLWNLTNIVFLHLGDNHLEGPISHFTIFEKLKRLSLVNNNFDGGLEFLSFNTQLERLDLSSNSLTGPIPSNISGLQNLECLYLSSNHLNGSIPSWIFSLPSLVELDLSNNTFSGKIQEFKSKTLSAVTLKQNKLKGRIPNSLLNQKNLQLLLLSHNNISGHISSAICNLKTLILLDLGSNNLEGTIPQCVVERNEYLSHLDLSKNRLSGTINTTFSVGNILRVISLHGNKLTGKVPRSMINCKYLTLLDLGNNMLNDTFPNWLGYLFQLKILSLRSNKLHGPIKSSGNTNLFMGLQILDLSSNGFSGNLPERILGNLQTMKEIDESTGFPEYISDPYDIYYNYLTTISTKGQDYDSVRILDSNMIINLSKNRFEGHIPSIIGDLVGLRTLNLSHNVLEGHIPASFQNLSVLESLDLSSNKISGEIPQQLASLTFLEVLNLSHNHLVGCIPKGKQFDSFGNTSYQGNDGLRGFPLSKLCGGEDQVTTPAELDQEEEEEDSPMISWQGVLVGYGCGLVIGLSVIYIMWSTQYPAWFSRMDLKLEHIITTKMKKHKKRY
Protein: Seminal vesicle secretory protein 2 (Q3UN62)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MKSSVFVLSLLLILERQSAVVGQYGATKGHFQSSSSEGFMLGQKGRLSFGIKGGSDEAAEESLFMQSQRRVYGQGGGDMTQTRVSQEHTSVKGAALCRNGQVSQLKSQESQIKSYGQVKSSGQLKSGGSAFGQVKSSVSQIKSYGQLKSGGQLKSGGPAFGQVKSQESQMKSYGQLKSSGQLKSGGSAFGQVKSSVSQIKSYGQLKSGGSQVKSYGQTKSYGEEGQLNSFSQLKSQGAQLKSYGQQKSQQQSSFSQVKSQSSQLKSYGQQKSLKGFSQQTQHKGFAMDEGMSQVRKQFSDDDLSVQQKSTQQMKTEEDLSQFGQQRQYGQERSQSYKGYLEQYRKKVQEQQRKNFNPGNYFTKGGADLYQAQLKG
Protein: Uncharacterized protein (Q57UJ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Small ribosomal subunit protein uS5 C-terminal domain-containing protein
- Mitochondrial ribosomal protein S18
- Uncharacterized protein
- Uncharacterized protein
- Treble clef zinc finger domain-containing protein
- Uncharacterized protein
- 30S Ribosomal protein S17, putative
- Uncharacterized protein
- Ribosomal protein S23 mitochondrial conserved domain-containing protein
- Trans-sialidase
Sequence:
MMRRVASTGSNGGHCYVGSSLWADSVYMEVSSITLQKRFSFKYATKLQHDEMRQPYYIHEKRYGIFSNERNIAKARRGLPFITPLYTKHMNLWDTDTDASNNRFFRGYYYGQRELHQLLGRPHSLEATNADGSNDLSTYEANTSQLYKGIPRPAITNLHYEPAWRYTLYQAGAHGAQLSNPRSPFTAKVLGDELMQVRDIKSVEHCKAWFDRLQYLINLHYEAVGDIGEFKSRHTRHVHEFFVAFHDALSSLDFRDTYLFDQFKAVRPPELSDLFGIFLEMEANYVHEDYCPRCSLPYSTTRYCGEGDVDTPFRKHRGRWAPHQKWGREWYDVVARRAEALWYRATEDPYFGTPQHTQRQAEALLKVYVQAKQRGKAIDFMNKLRGSVEYLTGDITITTVMQESYDALLDTTPHPHLLTNGFTLESDAAKYTGEVNKAPLSPLQFRIDMEMNKYRRQQKEEGVVRVPPALWRLDTSAIVPYKVDSKTRRIVNWREVKEGIEKSFLSVGLPKEAYTGNEWREMLYLHDVIANREAKAAVLEQQQKLDREKLKARERASLKGEKSSNSASNGIGIIFPDKDGYQVFFVDEASLRPFGIGASGTLFKAVARVYPSPAAVPYDDPVHGKQFLIDTTDETCHLFGGFEHGDRLLLRAKSSGGDVDGGNNSNCRNTGSFTDEEEEVIVMGVSTEGSDAERMLCAMHVDTGKQRERGIVFLGTDCIDIRERWESVRYAASAYVKGRVTLLESQRTAREEFMGQVVGIRDGVLFVQWRLLKGGGSVLDRSVAVPIGDSTQVRELFVETKVLGVEPLQSPPSWRTPFRNDFAEERLKELQRAPFKREKYVSLIQGKYTPKVKKFGYTQHTTVDDFETKEYKDRLLSKQFFQNPQAFEVVPDRNERSVQFGGKWEYQRTHGLPTVDRNELENGWSEVEPISDGEMKVIEQALRDISGPRPGNFVKPPSKTKSLQLSESWWEPLGYGWEQHNEEQKALCDVTEQRLIDGSNLPFGGKLPPFGTSYGMGERMRAIIEDYSKGFGLGPHGHSPTHDTIHYNTLNAEGERVRDLGYTDALGRLFSEKLGDRDVHQWAVESCADGEADVRQLLLSLHEWRERGRPPSLLLANVLSKYLEEEIAAFNKGIPENAPKLQLETSDGTLAHSGSGGSRSGTMWADVDPTTFALHQASQSIRSTRCDEPFILHLVKRAKLGECVTNFTDTAYIAHLESSVINEFHLALTKLVGKGISPTLLAQKTGQLHRGSVRVGGNVVPFVKSRELSRLLERMGLTSESIAVITRGLANCPEQESVGDDFAVPVSLILSWDGPGSSGGSGSGDRRLNTTAVRNEQQRKGSAALSSAIRQLSQHQKQRGSASGRGWQNEDKMVVHVLEELSLRNDGLVMDIQYAIRENKKNRRLRWEFVTTLLPVFGGNEAKVEQLYSDYCDGKYVPNITVAVEAFIAFLHNATQHPETYSASDYFDIDDGKSSTASGTGDQPSAGQYTTLKLLDPLEGPFVFDNVKVEYIQTVERFRRHGIRAGPVMAPATGFIAANCKSLNYFTRRQEEVVYVTNDSDQGLRRSLENSAYHKTIAANPALQYLLKARRGAALVETFNRFFYRTMPMLNFYQNVLKHYSETIQPLRQAAKSSTRGLARALESERSAAMEEFRRNSERYWRNIIEGRSVEQVVLANGESNRRTVGGGAGEQLQKPQGNHDAVRTNFTGEATDGSRKGQRQHQQPPLSQQQQHSRGEGERSAVHTSPRQGGSRGMADLLSRLNTPKTGSGVKGSTAKNTGNNRRGPKS
Protein: Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI) (P00946)
Organism: Escherichia coli (strain K12)
Function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Phosphomannomutase
- Glucose-6-phosphate isomerase
- Mannitol-1-phosphate 5-dehydrogenase
- Fructokinase
- PTS system mannose-specific EIIAB component
- D-allulose-6-phosphate 3-epimerase
- Glucosamine-6-phosphate deaminase
- ATP-dependent 6-phosphofructokinase isozyme 1
- Glutamine--fructose-6-phosphate aminotransferase
- ATP-dependent 6-phosphofructokinase isozyme 2
Sequence:
MQKLINSVQNYAWGSKTALTELYGMENPSSQPMAELWMGAHPKSSSRVQNAAGDIVSLRDVIESDKSTLLGEAVAKRFGELPFLFKVLCAAQPLSIQVHPNKHNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSEIVSLLQPVAGAHPAIAHFLQQPDAERLSELFASLLNMQGEEKSRALAILKSALDSQQGEPWQTIRLISEFYPEDSGLFSPLLLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEAKPANQLLTQPVKQGAELDFPIPVDDFAFSLHDLSDKETTISQQSAAILFCVEGDATLWKGSQQLQLKPGESAFIAANESPVTVKGHGRLARVYNKL
Protein: Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) (Q9UQX0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:11350071}.
Interaction partners:
- Superoxide dismutase
- Small ribosomal subunit protein mS43
- Catalase
- Putative thiosulfate sulfurtransferase, mitochondrial
- Glutathione peroxidase-like peroxiredoxin gpx1
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL29m
- Small ribosomal subunit protein bS18m
- Large ribosomal subunit protein mL46
Sequence:
MLRFLSKNSVAAIRNVSIARGVHTKATLPPLPYAYNALEPALSETIMKLHHDKHHQTYVNNLNAAQEKLADPNLDLEGEVALQAAIKFNGGGHINHSLFWKILAPQKEGGGKPVTSGSLHKAITSKWGSLEDFQKEMNAALASIQGSGWAWLIVDKDGSLRITTTANQDTIVKSKPIIGIDAWEHAYYPQYENRKAEYFKAIWNVINWKEAESRYSNR
Protein: Translocon component PTEX88 (Q8IIU7)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Translocon component PTEX150
- Heat shock protein 101
- Thioredoxin 2
- Exported protein 2
Sequence:
MIYQYIFVLCILLVHVGQCMYKIKQSGDILLSSQHNSLMNVKVVGKDNSFNLELNNMIKFPTNCIPFSTIDYNNKKGKKPIYYIKHEFKNLIFLYKNNVNIMQMVFPDRLYMVGIAANNGLLLTLTDVDIYRIDTKKKKVLLSRIKPGKYAHILNNRELFYTGVIGDSVLNKFFVTAAIRNNYYILHMEYNEENESIEILNVIDKVNGQYLRVLNDISIVGDVLYITENAENIVQIIINREKNTIQEKNIYTFNNNDKIVGISASRHTLYNNNNDMVDKYVNHNMKDNQNKPADNMNDLSNNTMIITVDYILVNSKKMFKEKPSSEGCLYLLKITKDSVEKYTIVDLFSKDINSFYFTIYDAHISLDDDYKKSGIVEALHKQKRKFLNFDIPNDEDEPTNNINSNENNKNQNNNNNNINVVKIVWTNYYNCTINKGIVDLRNVKIDEDSKEKKLPFVNVTNQFSLAPHIGASSYCSRKEKIFNDICYYDNRNNYVSLLNKSEEYNLRYQGNFVFDGYRIYLGFDYKSFQDTHIITYPINNMLYVYMTKGFVTINLPQPYGISIDSKSSTNNQIVVYITGNDEQHNYVNKCVIKKVEKAYDCFVVHKKKKEANELFQYISHISYGDNEEKLSTYIYVTNNKKTIYKLTKQENKWNFEKWFNLDNPSIRVGPISTSVNYFYVQRNVLEDLIKKYPDSALLSKFINVNEQDLHITEDGYIFLTLFHTVIFTSNNDAYGNDSGSTIHFYTSILKEKFYQSFGVDSIIYNIENDSKFSYYLS
Protein: Amylo-1,6-glucosidase, 4-alpha-glucanotransferase (E0CYU6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MEHSKQIRILLLNEMEKLEKTLFRLEQGFELQFRLGPTLQGKAVTVYTNYPLPGEAFNREKFRSLDWENPTEREDDSDKYCKLHLQQSGSFQYYFLQGNEKSGGGYIVVDPILRIGVDNHVLPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHFTPLQTLGLSRSCYSLADQLELNPDFSRPSKRYTWSDVGQLVEKLKREWNILCITDVVYNHTVTSYSPLENWQY
Protein: Amino acid APC family transporter (Q9I6R8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Probable aldehyde dehydrogenase
- Probable aminotransferase
- Gamma-aminobutyric acid-binding protein
- Probable transcriptional regulator
- Amino acid ABC transporter ATP binding protein
- Amino acid ABC transporter periplasmic binding protein
- Amino acid ABC transporter membrane protein
- Tryptophan 2-monooxygenase
- Probable amino acid permease
Sequence:
MNDTPNVREPALRRVLGLGPLLAVAIGLVVSQGVMVLMLQGAGTAGLGFIVPLGVAYLLALSYAFSFSELALMIPRAGSLSSYTEVAIGHFPAILATFSGYVVVAMFALSAELLLLDLIIGKVYPGALPPMLVAYGVLGLFTLLNLLGIDIFARLQSALALLMMIVLLVLGLGAVSSDHASAQTALASGWNPLGVSALALTAMAVWGFVGAEFVCPLVEETRRPERNIPRSMILGLSIIFLTIALYCFGALLCIPQAELAGDPLPHFLFANRVFGEYGQLFLVIAAITATCSTLNSSLAAIPRMLYGMAQNGQAFPQFKQLSRRARTPWVAVLFVAAITGLPILILGQDPDSINLLLLAAALAWLLAYIIAHVDVLALRRRYPHIARPFRTPFYPLPQLFGIAGMIYAVVHVSPTPEMTGRIFASAGVVLGVVSLVAVVWIKGVMRKPLFVPEPLETAGETAQGKSVALDPLQSPSA
Protein: Peroxisomal and mitochondrial division factor 2 (Ubiquitin-interacting factor 7) (Q9SHJ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in morphogenesis and proliferation of mitochondria. Does not act redundantly with PMD1. Is not involved in peroxisomal proliferation.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:21896887, ECO:0000269|PubMed:22147290}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial fission protein ELM1
- Dynamin-related protein 3B
- Dynamin-related protein 3A
- Mitochondrial fission 1 protein A
- Mitochondrial fission 1 protein B
- Mitochondrial import receptor subunit TOM20-1
- At5g06180)
- Signal peptidase complex subunit 1
- Protein PLANT CADMIUM RESISTANCE 12
- MICOS complex subunit Mic10-like protein
Sequence:
MAEERSLNGEATGQDDESFFDSDQQGDDGKSTELNQKIGDLESQNQELARDNDAINRKIESLTAEIEELRGAESKAKRKMGEMEREIDKSDEERKVLEAIASRASELETEVARLQHELITARTEGEEATAEAEKLRSEISQKGGGIEELEKEVAGLRTVKEENEKRMKELESKLGALEVKELDEKNKKFRAEEEMREKIDNKEKEVHDLKEKIKSLESDVAKGKTELQKWITEKMVVEDSLKDSEKKVVALESEIVELQKQLDDAEKMINGLKNVVEEPLNGIEFKSWSPNVTAVGSGGAVAAVAVAVAGAAVVCYIYHSRRV
Protein: C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) (Q8IY22)
Organism: Homo sapiens (Human)
Function: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.
Subcellular location: Nucleus {ECO:0000269|PubMed:12939343}. Cytoplasm {ECO:0000269|PubMed:12939343}. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343, PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343, PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343). {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15616553}.
Interaction partners:
- Calcium-transporting ATPase type 2C member 2
- Filamin-A
- Transcription factor p65
Sequence:
MDVTSSSGGGGDPRQIEETKPLLGGDVSAPEGTKMGAVPCRRALLLCNGMRYKLLQEGDIQVCVIRHPRTFLSKILTSKFLRRWEPHHLTLADNSLASATPTGYMENSVSYSAIEDVQLLSWENAPKYCLQLTIPGGTVLLQAANSYLRDQWFHSLQWKKKIYKYKKVLSNPSRWEVVLKEIRTLVDMALTSPLQDDSINQAPLEIVSKLLSENTNLTTQEHENIIVAIAPLLENNHPPPDLCEFFCKHCRERPRSMVVIEVFTPVVQRILKHNMDFGKCPRLRLFTQEYILALNELNAGMEVVKKFIQSMHGPTGHCPHPRVLPNLVAVCLAAIYSCYEEFINSRDNSPSLKEIRNGCQQPCDRKPTLPLRLLHPSPDLVSQEATLSEARLKSVVVASSEIHVEVERTSTAKPALTASAGNDSEPNLIDCLMVSPACSTMSIELGPQADRTLGCYVEILKLLSDYDDWRPSLASLLQPIPFPKEALAHEKFTKELKYVIQRFAEDPRQEVHSCLLSVRAGKDGWFQLYSPGGVACDDDGELFASMVHILMGSCYKTKKFLLSLAENKLGPCMLLALRGNQTMVEILCLMLEYNIIDNNDTQLQIISTLESTDVGKRMYEQLCDRQRELKELQRKGGPTRLTLPSKSTDADLARLLSSGSFGNLENLSLAFTNVTSACAEHLIKLPSLKQLNLWSTQFGDAGLRLLSEHLTMLQVLNLCETPVTDAGLLALSSMKSLCSLNMNSTKLSADTYEDLKAKLPNLKEVDVRYTEAW