wanglab/gogpt-training-data huggingface dataset:
Protein: Coatomer subunit gamma (Q382Z1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR037093}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR037093}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR037093}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR037093}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000256|PIRNR:PIRNR037093}; Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR037093}; Cytoplasmic side {ECO:0000256|PIRNR:PIRNR037093}.
Interaction partners:
- Coatomer subunit beta'
- Coatomer subunit zeta
- Coatomer subunit beta
- Coatomer subunit alpha
- Coatomer subunit delta
- Coatomer subunit epsilon
- ADP-ribosylation factor GTPase activating protein, putative
- SEC7 domain-containing protein
- ER lumen protein-retaining receptor
- Vesicle-associated membrane protein, putative
Sequence:
MQHDRDRYDSEEDDEESLPFDGIEKASVLQQCRVFNDVQLDISACLRCLTECLYLIYTGTTFTEAEATELFFMSTKLLQSNRSRLRRLHYVLMKELSPFVEQSFIASNSLMGDTKSNNESNKRNGMRTLCKVMNPSLYPLLDRTIVESLTSRSEKVLLASLITGFHVALSHPDLARKWSTQLNEAIRVLGNTQYLTVAIMHIIRKSDRVTVKRFIEQVRNGVVRSPLALSFLVKLTTDVLQEGFEEDPEVKKYIATMRHSSSEIVVFDTLRCMCVAGNASPQQFALVASVAQIYLNAKTSVSRFCAIRVLHDLAAIYPDAVTPISSDIEQLIMDQNRFTASFAMLTLLKTGTEASVERLIGALGSVGQLRELPDEFKVAITLELRSVSARFPQRYNLFLGFLVKLLSDDGSSTFKESIVEVITSVAKANDGAREAALKHLVDYVEDCAHVSILHRVHMYLGDEVPRSENPALFIRYINNHAALEFPEVRAAAVSTFARIAARVPSLRRSILPLLKHKCSDEDDEVRDRAIMYTKVFLLGDEDVIHSMVTEVSNTVAARRKLITPMTPTPLLEPVKRRMCQADHSTVAVETGIGKEAAHSSSGGGSVPGNQYSSAISEGRAKLLKIKQLQELGEPRASSEPVPLSDPDSEYFVTLIKHVYVAHVVLQFRVKNTMDSVVFRRVTVEMDTEELDAEPLYAIPISAIEPGATEYAYAVLQYSEGRYPSGTLGCRIKFALQERDGSSVAGEGEEEYPLEDFEVNVSDFITPIDLGECFQQKWEELRQEETCGTYALSSMRNLTAAAHELVEFFGMHVVGGKVDKITAASHTLLMSGSMVDGASSLVMINARLFIATDNTVALQLTLRGGSSELREYLSGALLS
Protein: Carboxylic ester hydrolase LipN (EC 3.1.1.-) (P95125)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Non specific carboxylic ester hydrolase. Hydrolyzes various pNP-esters, with a preference for short carbon chain substrates. Can also hydrolyze tributyrin to di- and monobutyrin and 4-hydroxyphenylacetate to hydroquinone.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26212120}.
Interaction partners:
- Probable carboxylic ester hydrolase LipM
- Possible conserved membrane protein
- Possible conserved membrane or secreted protein
- Probable conserved integral membrane protein
- Uncharacterized protein
- Pyruvate carboxylase
- Triacylglycerol lipase
- Esterase LipQ
- Aldo-keto reductase Rv2971
- Phospholipase Culp4
Sequence:
MTKSLPGVADLRLGANHPRMWTRRVQGTVVNVGVKVLPWIPTPAKRILSAGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDDIVASRAHMRAICEAMPGPQIHVDVTDLSIPGPAGEIPARHYRPSGGGATPLLVFYHGGGWTLGDLDTHDALCRLTCRDADIQVLSIDYRLAPEHPAPAAVEDAYAAFVWAHEHASDEFGALPGRVAVGGDSAGGNLSAVVCQLARDKARYEGGPTPVLQWLLYPRTDFTAQTRSMGLFGNGFLLTKRDIDWFHTQYLRDSDVDPADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVDLRYLGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV
Protein: Defensin (Galiomicin) (P85213)
Organism: Galleria mellonella (Greater wax moth)
Function: Has antifungal activity against A.niger (MIC=2.1 uM), C.albicans (MIC=8.5 uM), C.fructus (MIC=8.5 uM), F.oxysporum (MIC=16.9 uM), P.pastoris (MIC=16.9 uM), P.tannophilus (MIC=8.5 uM), T.harzianum (MIC=4.2 uM), and Z.marxianus (MIC=8.5 uM). Lacks antibacterial activity against the Gram-positive bacteria L.monocytogenes, M.luteus, S.aureus, and S.lutea, and the Gram-negative bacteria E.coli D31, E.coli ATCC 25922, and S.typhimurium.
Subcellular location: Secreted {ECO:0000255|PROSITE-ProRule:PRU00710, ECO:0000269|PubMed:14728668, ECO:0000269|PubMed:17194500, ECO:0000269|PubMed:34443685}. Note=Secreted in the hemolymph. {ECO:0000269|PubMed:14728668, ECO:0000269|PubMed:17194500, ECO:0000269|PubMed:34443685}.
Interaction partners:
Sequence:
MAKNFQSVLLLVCLSFLVIVSSPQNAVQADTLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFLNVNCWCE
Protein: L-galactonate-5-dehydrogenase (EC 1.1.1.414) (P39400)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the oxidation of L-galactonate to D-tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate.
Interaction partners:
- Probable HTH-type transcriptional regulator LgoR
- Starvation-sensing protein RspB
- Uronate isomerase
- L-arabinose isomerase
- Beta-glucuronidase
- Probable L-galactonate transporter
Sequence:
MSTMNVLICQQPKELVWKQREIPIPGDNEALIKIKSVGICGTDIHAWGGNQPFFSYPRVLGHEICGEIVGLGKNIADLKNGQQVAVIPYVACQQCPACKSGRTNCCEKISVIGVHQDGGFSEYLSVPVANILPADGIDPQAAALIEPFAISAHAVRRAAIAPGEQVLVVGAGPIGLGAAAIAKADGAQVVVADTSPARREHVATRLELPLLDPSAEDFDAQLRAQFGGSLAQKVIDATGNQHAMNNTVNLIRHGGTVVFVGLFKGELQFSDPEFHKKETTMMGSRNATPEDFAKVGRLMAEGKITADMMLTHRYPFATLAETYERDVINNRELIKGVITF
Protein: Uncharacterized protein YjbB (P0AF43)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLTLLHLLSAVALLVWGTHIVRTGVMRVFGARLRTVLSRSVEKKPLAFCAGIGVTALVQSSNATTMLVTSFVAQDLVALAPALVIVLGADVGTALMARILTFDLSWLSPLLIFIGVIFFLGRKQSRAGQLGRVGIGLGLILLALELIVQAVTPITQANGVQVIFASLTGDILLDALIGAMFAIISYSSLAAVLLTATLTAAGIISFPVALCLVIGANLGSGLLAMLNNSAANAAARRVALGSLLFKLVGSLIILPFVHLLAETMGKLSLPKAELVIYFHVFYNLVRCLVMLPFVDPMARFCKTIIRDEPELDTQLRPKHLDVSALDTPTLALANAARETLRIGDAMEQMMEGLNKVMHGEPRQEKELRKLADDINVLYTAIKLYLARMPKEELAEEESRRWAEIIEMSLNLEQASDIVERMGSEIADKSLAARRAFSLDGLKELDALYEQLLSNLKLAMSVFFSGDVTSARRLRRSKHRFRILNRRYSHAHVDRLHQQNVQSIETSSLHLGLLGDMQRLNSLFCSVAYSVLEQPDEDEGRDEY
Protein: 2'-5' oligoadenylate synthase (EC 2.7.7.84) (G3SFB1)
Organism: Gorilla gorilla gorilla (Western lowland gorilla)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- 2'-5' oligoadenylate synthase
- 2'-5'-oligoadenylate synthase 3
- MX dynamin like GTPase 1
- Ubiquitin-like protein ISG15
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Interferon induced protein with tetratricopeptide repeats 1
- Interferon-induced protein 44
- Interferon alpha inducible protein 6
- Interferon regulatory factor 7
- Interferon induced protein with tetratricopeptide repeats 3
Sequence:
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTALRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIKECTYLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWEQGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLRKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLTQHTPGSIHPTGRRGLDLHHPLNASASWGKGLQCYLDQFLHFQVGLLIQRGQSSSVSWCIIQDRTQVS
Protein: Stellate protein CG33246 (Q7KV22)
Organism: Drosophila melanogaster (Fruit fly)
Function: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.
Interaction partners:
- Casein kinase II subunit alpha
- Casein kinase II subunit beta
- Stellate protein CG33243
- Stellate protein CG33247
- Stellate protein CG33236/CG33240/CG33244/CG33245
- Ste:CG33242
- Segment polarity protein dishevelled
- Stellate protein CG33238
- Stellate protein CG33237
- Stellate protein CG33239/CG33241
Sequence:
MSSSQNNNSSWIDWFLGIKGNQFLCRVPTDYVQDTFNQMGLEYFSEILDVILKPVIDSSSGLLYGDGKKWYGMIHARYIRSERGLIAMHRKYMRGDFGSCPNISCDRQNTLPVGLSAVWGKSTVKIHCPRCKSNFYPKSDTQLDGAMFGPSFPDIFFSLLPNLTSPLDDPRT
Protein: Uncharacterized cox1 intron-2 37.2 kDa protein (Probable maturase) (P22190)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Probable intron-encoded endonuclease Cox1-I1b
- Cytochrome c1, heme protein, mitochondrial
- ATP synthase subunit a
- Uncharacterized 91 kDa protein in cob intron
- Cytochrome b
- Cytochrome c
- Cytochrome c oxidase subunit 4, mitochondrial
Sequence:
NLIGLLTLLYAGTTWKILDKSFCFKYSKKNTRLVFIFIVKMLKQLSISAGNLLNKGTSETLRNEITTKKVSIHLPKHLKPANDSQFGHYLAGLIDGDGHFSSKQQLIIAFHSLDIQLAYYIKKQIGYGIVRKIKDKNAILFIIANSKGIERVITLINNKFRTTSKYNQIINNIFAHPRFKEFSKTITLGLNSNNNLNNHWLAGFSDADASFQIKILNRDKKIEVRLNYQIDQKKEYLLSLIKDNLGGNIGYRKSQDTYYYGSTSFGSAKKVINYFDNYHLLSSKYISYLKWRKAYLIIQENKHLTESGLSQIKKPHPYRKNIN
Protein: Protein FAM136A (Q96C01)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAELQQLRVQEAVESMVKSLERENIRKMQGLMFRCSASCCEDSQASMKQVHQCIERCHVPLAQAQALVTSELEKFQDRLARCTMHCNDKAKDSIDAGSKELQVKQQLDSCVTKCVDDHMHLIPTMTKKMKEALLSIGK
Protein: Homeo box A13 (A0A0G2K6K0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MTASVLLHPRWIEPTVMFLYDNGGGLVADELNKNMEGAAAAAAAAAAAAAAGAGGGGFPHPAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPAPLAPGAAAAYSSAPGEAPPTAAAAAAAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSPCSAAAQSSSGPAALPYGYFGSGYYPCARMGPHPNAIKSCAQPASAAAAFADKYMDTAGPAAEEFSSRAKEFAFYHQGYAAGPYHHHQPVPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQMYCPKEQTQPPHLWKSTLPDVVSHPSDASSYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTNLSERQVTIWFQNRRVKEKKVINKLKTTS
Protein: Ptr2p (A0A1D8PS27)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003755}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003755}.
Interaction partners:
- Oligopeptide transporter
Sequence:
MVSSDFENEKQPDVVQVLTDEKNISLDDKYDYEDPKNYSTNYVDDYNPKGLRRPTPQESKSLRRVIGNIRYSTFMLCICEFAERASYYSTTGILTNYIQRRIDPDSPHGWGAPPPGSPDASAGALGKGLQAASALTNLLTFLAYVFPLIGGYLGDSTIGRWKAIQWGVFFGFVGHLFFIFASIPQAIENANAGLGLCVIAIITLSAGSGLMKPNLLPLVLDQYPEERDMVKVLPTGESIILDREKSLSRITNVFYLAINIGAFLQIATSYCERRVGFWLAFFVPMILYIIVPIFLFIVKPKLKIKPPQGQVMTNVVKILAVLFSGNFIKRLWNGTFWDHARPSHMEARGTIYYNSKKKSAITWSDQWILDIKQTFDSCKIFLYYIIFNLADSGLGSVETSLIGAMKLDGVPNDLFNNFNPLTIIILIPILEYGLYPLLNKFKIDFKPIWRICFGFVVCSFSQIAGFVLQKQVYEQSPCGYYATNCDSPAPITAWKASSLFILAAAGECWAYTTAYELAYTRSPPALKSLVYALFLVMSAFSAALSLAITPALKDPNLHWVFLAIGLAGFLCAIVMLAQFWNLDKWMENETNERERLDREEEEEANRGIHDVDHPIEAIVSIKS
Protein: Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Aspartate 1-decarboxylase) (EC 4.1.1.11) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) (Q64611)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate.
Interaction partners:
- Cysteine dioxygenase type 1
- Bile acid-CoA:amino acid N-acyltransferase
- Acyl-coenzyme A amino acid N-acyltransferase 1
- Acyl-coenzyme A amino acid N-acyltransferase 2
- Glutathione hydrolase 5 proenzyme
- Glutathione hydrolase 7
- Glutathione hydrolase 6
- Glutamate decarboxylase 2
- Glutamate decarboxylase 1
- Aspartate aminotransferase, cytoplasmic
Sequence:
MADSKPLRTLDGDPVAVEALLRDVFGIVVDEAIRKGTNASEKVCEWKEPEELKQLLDLELQSQGESRERILERCRAVIHYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNTGDGVFCPGGSISNMYAINLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGKMIPEDLERQISLAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWLHVDAAWGGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQASYLFQQDKFYNVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLEWRIDQAFALTRYLVEEIKKREGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGTMMIGYQPHGTRANFFRMVVANPILVQADIDFLLGELERLGQDL
Protein: Fungal lipase-like domain-containing protein (Q580K0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSIFYNFLPAKPETTSPSSLSKLTPDEVPSLPLVSHYVYALLSLHVYGIADAPPLPKPWNLHLTAAELGLDKDGYFAASYINEELRHCIIAHRGTADALSLRSGVWYYFNERTILFSLAQQFSKQVRIHLSATKGEGEGEWFISYTGHSLGAVLAACRAVEDRAPAITFESPGCKLFIENTLYQHKADDGDIITYLREPNPINTLRPHCGYIVQLHPIQDDAVAAQAGAAVASKPRLAAIFNAQEAVRGLFQRAAGIPDIQHYLGKIEPLIREMVEHTQQAHSMSSVLRHFKENEEPLAYAVLRWPENALQFMEFYNAKKVLEVRENTQQNLVAAYESLIRTMYVVVEHPKNSLPLRYLSKDALKLLRLWSRESPSKLARMPFTEMDHKVLNTIIIEDGCMRTSVLTAFQAKQYISLVVFKPEIRQVLDRLLLDPLLENASKM
Protein: Ribose operon repressor (P0ACQ0)
Organism: Escherichia coli (strain K12)
Function: Transcriptional repressor for the ribose rbsDACBK operon. RbsR binds to a region of perfect dyad symmetry spanning the rbs operon transcriptional start site. The affinity for the rbs operator is reduced by addition of ribose, consistent with ribose being the inducer of the operon.
Interaction partners:
- Ribokinase
- D-ribose pyranase
- Ribose import ATP-binding protein RbsA
- Ribose import permease protein RbsC
- Ornithine carbamoyltransferase subunit F
- Ribose import binding protein RbsB
Sequence:
MATMKDVARLAGVSTSTVSHVINKDRFVSEAITAKVEAAIKELNYAPSALARSLKLNQTHTIGMLITASTNPFYSELVRGVERSCFERGYSLVLCNTEGDEQRMNRNLETLMQKRVDGLLLLCTETHQPSREIMQRYPTVPTVMMDWAPFDGDSDLIQDNSLLGGDLATQYLIDKGHTRIACITGPLDKTPARLRLEGYRAAMKRAGLNIPDGYEVTGDFEFNGGFDAMRQLLSHPLRPQAVFTGNDAMAVGVYQALYQAELQVPQDIAVIGYDDIELASFMTPPLTTIHQPKDELGELAIDVLIHRITQPTLQQQRLQLTPILMERGSA
Protein: Growth hormone (A7UIY9)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MMAAGPRTSLLLAFTLLCLPWTQVVGAFPAMSLSGLFANAVLRAQHLHQLVADTFKEFEHTYIPEGQRYSIQNTQVAFCFSETIPAPTGKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDVTPRAGQILKQTYDKFDTNMRSDNALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
Protein: Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer) (Q7Z7G1)
Organism: Homo sapiens (Human)
Function: An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26009488}.
Interaction partners:
- Linker for activation of T-cells family member 1
Sequence:
MNRQGNRKTTKEGSNDLKFQNFSLPKNRSWPRINSATGQYQRMNKPLLDWERNFAAVLDGAKGHSDDDYDDPELRMEETWQSIKILPARPIKESEYADTHYFKVAMDTPLPLDTRTSISIGQPTWNTQTRLERVDKPISKDVRSQNIKGDASVRKNKIPLPPPRPLITLPKKYQPLPPEPESSRPPLSQRHTFPEVQRMPSQISLRDLSEVLEAEKVPHNQRKPESTHLLENQNTQEIPLAISSSSFTTSNHSVQNRDHRGGMQPCSPQRCQPPASCSPHENILPYKYTSWRPPFPKRSDRKDVQHNEWYIGEYSRQAVEEAFMKENKDGSFLVRDCSTKSKEEPYVLAVFYENKVYNVKIRFLERNQQFALGTGLRGDEKFDSVEDIIEHYKNFPIILIDGKDKTGVHRKQCHLTQPLPLTRHLLPL
Protein: Proton pump-interactor 1 (O23144)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes AHA1 plasma membrane ATPase activity by binding to a site different from the 14-3-3 binding site.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19796364}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19796364}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- CwfJ-like family protein
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Endoplasmic reticulum transmembrane protein
- ATPase 1, plasma membrane-type
- Probable protein phosphatase 2C 9
- NAC domain containing protein 38
Sequence:
MGVEVVNSGGFEVAPAPFEGKPEKNGKLDQGKGDDAPINFGSVGELPKNAEENNNKVVNSDAPKNAAEEWPVAKQIHSFYLVKYRSYADPKIKAKLDLADKELEKLNKARTGVLDKLRAKRAERSELFDLLDPLKSERKGFNTMFDEKRKEMEPLQQALGKLRSNDGGSARGPAICSSEEELNSMIYSYQYRIQHESIPLTEEKQILKEIRLLEGTRDKVIANAAMRAKIKESMGQKDDIQGQVKLMGAGLDGVKKERQAISARINELSEKLKATKDEITVLENELKTVSEKRDKAYSNIHDLRRQRDETNSEYYQNRTVLNKARDLAAQKNISELEALANAEVEKFISLWCSKKNFREDYEKRILQSLDSRQLSRDGRMRNPDEKPLIAPEAAPSKATPSETEVVPKAKAKPQPKEEPVSAPKPDATVAQNTEKAKDAVKVKNVADDDDDEVYGLGKPQKEEKPVDAATAKEMRKQEEIAKAKQAMERKKKLAEKAAAKAAIRAQKEAEKKEKKEQEKKAKKKTGGNTETETEEVPEASEEEIEAPVQEEKPQKEKVFKEKPIRNRTRGRGPETIPRAILKRKKSTNYWVYAAPAALVVLLLLVLGYYYVL
Protein: Transcription initiation factor IIB (General transcription factor TFIIB) (P29052)
Organism: Drosophila melanogaster (Fruit fly)
Function: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Subcellular location: Nucleus.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB3
- TATA-box-binding protein
- ENL/AF9-related, isoform B
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- General transcription factor IIF subunit 2
- General transcription factor IIE subunit 1
- DNA-directed RNA polymerase II subunit RPB1
- Transcription initiation factor TFIID subunit 1
- DNA-directed RNA polymerase II subunit RPB2
- General transcription factor IIF subunit 1
Sequence:
MASTSRLDNNKVCCYAHPESPLIEDYRAGDMICSECGLVVGDRVIDVGSEWRTFSNEKSGVDPSRVGGPENPLLSGGDLSTIIGPGTGSASFDAFGAPKYQNRRTMSSSDRSLISAFKEISSMADRINLPKTIVDRANNLFKQVHDGKNLKGRSNDAKASACLYIACRQEGVPRTFKEICAVSKISKKEIGRCFKLTLKALETSVDLITTADFMCRFCANLDLPNMVQRAATHIAKKAVEMDIVPGRSPISVAAAAIYMASQASEHKRSQKEIGDIAGVADVTIRQSYKLMYPHAAKLFPEDFKFTTPIDQLPQM
Protein: General transcription and DNA repair factor IIH subunit tfb4 (TFIIH subunit tfb4) (RNA polymerase II transcription factor B subunit 4) (O74366)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- General transcription and DNA repair factor IIH subunit tfb2
- General transcription and DNA repair factor IIH subunit tfb1
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH subunit ssl1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- Cyclin mcs2
- Serine/threonine-protein kinase crk1
- RNA polymerase II transcription factor B subunit 3
- Transcription initiation factor IIE subunit alpha
- Transcription initiation factor IIE subunit beta
Sequence:
MDEFQTLKQNASWDISEDANDTPSLLVVILDANPASWYSLSKKVPVSKVLADITVFLNAHLAFHHDNRVAVLASHSDKVEYLYPSIAPEQKVAEVDPTKEANTYRKFREVDDLVLSGMKRLMSSTDKVSRKTMISGALSRALAYINQVQNKNTLRSRILIFSLTGDVALQYIPTMNCIFCAQKKNIPINVCNIEGGTLFLEQAADATGGIYLKVDNPKGLLQYLMMSLFPDQNLRKHLNTPNQANVDFRATCFCHKKVLDIGFVCSVCLSIFCEPRVHCSTCHTKFTVEPMSKKLHT
Protein: WD repeat domain 62, isoform G (M9PB01)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Microcephalin, isoform D
- Centrosomal protein 135kDa, isoform B
- Protein abnormal spindle
- Aurora kinase
Sequence:
MTPASLSASTPTLSTLHHQRMALQSQSQSPLASPLTPSPSSVFGSPKFPANYERSEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRKYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQTLPEECFVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSEIEQPQLQPKFGVAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNVQTSDYNSASSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSENLPQSSTNSFLHAALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEELLQVINKVKQQLENGTRKNGNTRLNAIAEVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQKPVDSHDTSQYTSPQNTTATAAPTNTQQQIQPPVQQQYQIPKEPHQQAQQQHQQYAPPASQQFFNCAAPKSKLQQNFQTMRQVQQHYPPYPHHVGVHQIHPPPGVPFGGSAAGSTSAMRSHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPVHEEVEWSAEGNERGALLGEPKRHSVYADDARTILDMIHADTEKMIDEITRKYGDLDEPGIPASYSMPANLRNLGGLGSTGDSTPTGRTTQYYVYREFYQCERKVSLSDILQPEQFAASQRRLDEARFLETQRHSSASFFLTGQQSQESLSLLSDGDGPGSYCNSLESVLSDESDCQSAPLEYPQTQVAVLQQRHAGIRNFIIHGPVSKSYGNSPNAYGSFDYYMRQQHSTTTDSFDVTGYNLEPLKPLPSSKTYPRIAQVQASENIPTLRSKNKQYTSGVNKSLSTDFAQQRQQRNSNPMQSGDNLFVRKPLKPKPPVPAKPHNLVSTLSHMEKQQKQKSQSRTASVVQQFEHNLQKFEKEKQREREQQRRPAMRSSVSSGALAGGSTTQSCLKKVSRFDTSESSRRATSVRQKNRPKISVRFNTVSQIKYTPSAKRERQAREEEPPEMEVGSLPSDYGERSFEMYFAENGNAPENLENMQTLKLYTKPQLQAVVDEIQQEREKYRKNLDNAGKISGKGGSGKGKGAGSSTSHQCQNIAKKIDIIEKLIAMEENKMEQIRLATESRLRPFNCNAKEKGYVKSLTMNFDMLARGEDPTEDEDLASKDASDLCAYARNIRRNCSLPDVLESTDFTGIYNSQGVELAKEVIADDESGDPVNPGITADSADHDGIGQTVVLRMEPGNPKTLNPMPIEESSIRRACSLSDLHMGNFGKPGKSQNGTPQKPQVQHRNGNVSRSASKRNSLQGKTGLGASSNSMNVLNQGSDSEPEDSNRLRSASNGQGRSNGPIAANRQYSNKINNVNNNRRKTPNFSSATPMQDDSSSEETPNSTVNNKPIVPPRPRNLAFDHKSKLMINNSGSPGGNAKQRSGVTSTEDFEGTDPEAQVHNVINKLYTTTQAAMQLHANLKNTLLLKELENALIMSRNMLSSITNRQADKTNNGGGGLGVGGSGGLNHDQLNADNGDYLMMVNNCADLLSNLRTKHKPDDCENNS
Protein: Possible conserved exported protein (O07236)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable conserved integral membrane protein
- Uncharacterized protein Rv2599
- N-acetylmuramoyl-L-alanine amidase Rv3717
- Uncharacterized protein Rv1303
Sequence:
MSRLLALLCAAVCTGCVAVVLAPVSLAVVNPWFANSVGNATQVVSVVGTGGSTAKMDVYQRTAAGWQPLKTGITTHIGSAGMAPEAKSGYPATPMGVYSLDSAFGTAPNPGGGLPYTQVGPNHWWSGDDNSPTFNSMQVCQKSQCPFSTADSENLQIPQYKHSVVMGVNKAKVPGKGSAFFFHTTDGGPTAGCVAIDDATLVQIIRWLRPGAVIAIAK
Protein: Potassium channel toxin alpha-KTx 19.2 (Toxin Kbot21) (C0HJQ2)
Organism: Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Function: Blocks voltage-gated potassium channels rKv1.1/KCNA1, rKv1.2/KCNA2, hKv1.3/KCNA3, rKv1.6/KCNA6 (IC(50)=75.9 nM) and, to a lesser extent, Shaker IR (with the inactivation domain removed).
Subcellular location: Secreted {ECO:0000269|PubMed:26398235}.
Interaction partners:
Sequence:
AACYSSDCRVKCRAMGFSSGKCIDSKCKCYK