wanglab/gogpt-training-data huggingface dataset:
Protein: Vascular endothelial growth factor B (E7EZR4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Si:dkeyp-98a7.4.
- Si:ch1073-75o15.4.
- SUEL-type lectin domain-containing protein.
- Si:ch211-226h8.8.
- Adhesion G protein-coupled receptor L1a
- Si:ch211-66i15.5.
- Uncharacterized protein LOC791752 precursor
- Si:dkeyp-98a7.4.
- Si:ch211-226h8.6.
- Si:ch211-12h2.8.
Sequence:
MGIKLRVILGMFQFVTLTRIPTQCARTQSDHWMPTQSHKSGEVVRWLDVFQRSGCHPRETLVEVWQEFPWETNHLFLPSCVTLRRCGGCCSDEALECVPSQTHTLVMELMKTSYMKHELVQLPFIEHNQCECRLKANLYAEPTRQGPQTTRRGRKRHRGKPKRKKHMGKNSMMLVPTTPPPPPPPTLPPSSAPPTPAREACPPCPIRKMTSHPPSCECRCSLREVSCTKRGKTLNQSSCRCETQSE
Protein: Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-) (Sialyltransferase 8E) (SIAT8-E) (Sialyltransferase St8Sia V) (ST8SiaV) (O15466)
Organism: Homo sapiens (Human)
Function: Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6ZXC8}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Lactosylceramide alpha-2,3-sialyltransferase
Sequence:
MRYADPSANRDLLGSRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC
Protein: Peptide chain release factor 1, putative (Q57WY8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Prokaryotic-type class I peptide chain release factors domain-containing protein
- peptide chain release factor N
- Methyltransferase small domain-containing protein
- 40S ribosomal protein S5, putative
- 50S ribosomal protein L17, putative
- 40S ribosomal protein S23, putative
- 40S ribosomal protein S14
- 60S ribosomal protein L17, putative
- Large ribosomal subunit protein bL21m
- 40S ribosomal protein S18, putative
Sequence:
MFICPLCVLFLQTSCMRNAPLLLFGAGGTLGGVKKIANPKTIPYHSWVLSEKSRVLLDSIHHPLVTEYFLRLNMRRVGLEQQQECADLASLHTKVGDTSYNHVMWNIQYRDELDVSERLSAHLLKINDNIKLKDQLHSHETLSDDDRDILLMVEEDVRELVEKVRDMDSDVNAVMTRRLNLSDALGSCTNTWSLEVAGKAGGEEASLFASELLEMYRAYATEIRHWSVDVDGGEGDGEPVSSGGPAVGGNGMKIKVKGEGVYRNLRHEIGVHKVQRVPVTDQDGKMQTSTAVVTLMPVLDPVSVDVHEKDCNIEFVRGSGPGGQGMQSSSNAVCLTHKPSGISVKCHQSRSALGNKELALQMVAQQLLVRRVKDQNSSLHETWCNQWSSGERSDKMRTYNYPQNRVTDHRLGRDYSLGTFLDGGAGLVGLHDDLNAIDDRQQLVRVLLQHIESDFNCVT
Protein: Transcription factor bHLH120 (Basic helix-loop-helix protein 120) (AtbHLH120) (bHLH 120) (Transcription factor EN 4) (bHLH transcription factor bHLH120) (Q9FLI0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Glucose-methanol-choline
- 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1
- Zinc finger CCCH domain-containing protein 63
- At1g12570
- Putative transcription factor bHLH086
- 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2
- Zinc finger CCCH domain-containing protein 48
Sequence:
MNPSNNPKKTRHQSHMPQERDETKKEKKLLHRNIERQRRQEMAILFASLRSQLPLKYIKGKRAMSDHVNGAVSFIKDTQTRIKDLSARRDELKREIGDPTSLTGSGSGSGSSRSEPASVMVQPCVSGFEVVVSSLASGLEAWPLSRVLEVLHGQGLEVISSLTARVNERLMYTIQVEVNSFDCFDLAWLQQKLIEQLVLSTTRH
Protein: Squalene synthase 12 (PgSS12) (SQS 12) (EC 2.5.1.21) (FPP:FPP farnesyltransferase SS12) (Farnesyl-diphosphate farnesyltransferase SS12) (A0A1P7Y0A8)
Organism: Panax ginseng (Korean ginseng)
Function: Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways. Catalyzes the biosynthesis of squalene (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P53799}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGSLGAILKHPDDFYPLLKLKIAARHAEKQIPSEPHWAFCYSMLHKVSRSFGLVIQQLGPQLRDAVCIFYLVLRALDTVEDDTSISTEVKVPIVMAFHCHIYDNDWHFSCGTKEYKVLMDEFHHVSNAFLDLGSSYKEAIEDITMRMGAGMAKFICKEVETIDDYDEYCHYVAGLVGLGLSKLFHASGAEDLATDSLSNSMGLFLQKTNIIRDYLEDINEIPKSRMFWPRQIWSKYVDKLEDLKYEENSAKAVQCLNDMVTDALVHAEDCLKYMSDLRGPAIFRFCAIPQIMAIGTLALCFNNTQVFRGVVKMRRGLTAKVIDQTKTMSDVYGAFFDFSCLLKSKVDNNDPNATKTLSRLEAIQKTCKESGTLSKRKSYIIESESGHNSALIAIIFIILAILYAYLSSNLLPNKQ
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (D4P3N9)
Organism: Triticum aestivum (Wheat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU361136}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU361136}.
Interaction partners:
Sequence:
MPKPAGDAKLLIQSLTKAYAATPTNLKIIDLYVVFAVATALVQVVYMGIVGSFPFNSFLSGVLSCIGTAVLGVCLRIQVNKDNKEFKDLPPERAFADFVLCNLVLHLVTMNFLG
Protein: Protein DOWNY MILDEW RESISTANCE 6 (AtDMR6) (EC 1.14.11.-) (2-oxoglutarate (2OG)-Fe(II) oxygenase-like protein DMR6) (Salicylate 3-hydroxylase DMR6) (S3H DMR6) (SA 3-hydroxylase DMR6) (Salicylic acid 3-hydroxylase DMR6) (EC 1.14.13.-) (Q9FLV0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Converts salicylic acid (SA) to 2,3-dihydroxybenzoic acid (2,3-DHBA) (By similarity). Suppressor of immunity. Regulates negatively defense associated genes expression (e.g. PR-1, PR-2, and PR-5). Negative regulator of defense against Hyaloperonospora arabidopsidis.
Interaction partners:
- Chitinase-like protein
- Homoserine kinase
- Probable pectate lyase 13
- Callose synthase 12
- MLO-like protein 1
Sequence:
MAAKLISTGFRHTTLPENYVRPISDRPRLSEVSQLEDFPLIDLSSTDRSFLIQQIHQACARFGFFQVINHGVNKQIIDEMVSVAREFFSMSMEEKMKLYSDDPTKTTRLSTSFNVKKEEVNNWRDYLRLHCYPIHKYVNEWPSNPPSFKEIVSKYSREVREVGFKIEELISESLGLEKDYMKKVLGEQGQHMAVNYYPPCPEPELTYGLPAHTDPNALTILLQDTTVCGLQILIDGQWFAVNPHPDAFVINIGDQLQALSNGVYKSVWHRAVTNTENPRLSVASFLCPADCAVMSPAKPLWEAEDDETKPVYKDFTYAEYYKKFWSRNLDQEHCLENFLNN
Protein: Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta) (P07633)
Organism: Rattus norvegicus (Rat)
Function: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P05166}.
Interaction partners:
- Propionyl-CoA carboxylase alpha chain, mitochondrial
- Methylmalonyl-CoA epimerase, mitochondrial
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- Peroxisomal acyl-coenzyme A oxidase 1
- Acyl-CoA synthetase short-chain family member 3, mitochondrial
- Trifunctional enzyme subunit beta, mitochondrial
Sequence:
MAAVIRIRAMAAGTRLRVLNCGLGTTIRSLCSQPVSVNERIENKRHAALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFLESDMFVEHRCADFGMAAEKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPEFVKSVTNEDVTQEQLGGAKTHTTVSGVAHRAFDNDVDALCNLREFLNFLPLSNQDPASIRECHDPSDRLVPELDTVVPLESSKAYNMLDIIHAVIDEREFFEIMPNYAKNIVIGFARMNGRTVGIVGNQPNVASGCLDINSSVKGARFVRFCDAFSIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKITVITRKAYGGAYDVMSSKHLLGDTNYAWPTAEIAVMGAKGAVEIIFKGHEDVEAAQAEYVEKFANPFPAAVRGFVDDIIQPSSTRARICCDLEVLASKKVHRPWRKHANVPL
Protein: Phosphopantothenoylcysteine synthetase, isoform A (EC 6.3.2.5) (Phosphopantothenoylcysteine synthetase, isoform D) (Q7KN99)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTHWEDFYNTHLPPADFEDNRSLLKEFCERHNKLQNRIVLVTSGGTTVPLEHNTVRFVDNFSAGTRGSASAEYFLDHDYAVIFMHRHKSLEPFTRHFTGQQFFDMLDIADNSQSSTIAIKPDSVDVFAPVLAKYKIARETQMILYVNFTSVVDYMWLLRAACECLAAFEERAVLYLAAAVSDFYIPEDMMPTHKMQSGDGAPTISLQLVPKMLAPLASLWVPHAFVVSFKLETDESLLIVKARDSLNKYKHKLVIANVLQTRKHRVVFVTPTDSYELHLTREQTLQGLEIEEPIVADVVQKHGEFISNAQQRQ
Protein: NPC intracellular cholesterol transporter 1 precursor (Niemann-Pick disease, type C1) (A0A0R4IZV0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MLLLGRNHIFRLLLATVLLSHWVHGQHCIWYGECGNSPNVPEKKLNCNYTGPAVPLPNEGQELLQELCPRLVYADNRVCCDTQQLNTLKSNIQIPLQYLSRCPACFFNFMTLFCELTCSPRQSQFISVKDFLKEKNQTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGRDASVCTPQIWIQYMFSISNGQVPFGIEPIFTDVPVQGMTPMNNRTFNCSQSLDDGSEPCSCQDCSEVCGPTPVPPPIPPPWIILGLDAMSFIMWCSYIAFLLIFFGVVLGAWCYRRSVVTSEYGPILDSNQPHSLNSDDEASCCETVGERFENSLRLVFSRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVELWSAPSSRARQEKNYFDQHFGPFFRTEQLIITTPWTEEGGFSTITGDIIPFSPILNLSLLHQVLDLQLEIENLIAEYKGENVTLKDICVSPLSPYNDNCTILSVLNYFQNSHEVLDHEFQDEFFLYNDYHTHLLYCASSPTSLDDTSRLHDPCMGTFGGPVFPWLVLGGYEDSAYNNATALVITFPVTNYLNDTEKLGKALAWEKEFIRFMKNYENPNLTVSFSSERSIEDEIDRESNSDVSTIVISYIIMFVYISVALGRINSCRTLLVDSKISLGIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTYQRDERMPEEELHQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKLSDGQEEKSEGWLFRFFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYFGNLSKYLHTGPPVYFVVEDGHDYKTFEGQNAVCGGVGCNNDSLVQQIYTASLMSNYTRISNVPSSWLDDYFDWVKPQSTCCRYYNSTGAFCNASVVDKSCVHCRPMTSSGKQRPNGTEFMHFLPMFLSDNPNIKCGKGGHAAYGTAVDLKDNNTDVGATYFMSYHTILKNSSDFINAMKMARELTDNITQTLSTHDKSYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGFELWSAVLVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRSSRVERAEEALAHMGSSVFSGITLTKFGGILILALSKSQIFQIFYFRMYLAIVLLGAAHGLIFLPVLLSYAGPSVNKAKVLAAHNRFVGTERERLIY
Protein: Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Q921W0)
Organism: Mus musculus (Mouse)
Function: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11559747}. Endosome membrane {ECO:0000269|PubMed:11559747}; Peripheral membrane protein {ECO:0000269|PubMed:11559747}. Nucleus matrix {ECO:0000269|PubMed:11559747}. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
Interaction partners:
- Charged multivesicular body protein 3
- Vacuolar protein sorting-associated protein VTA1 homolog
- Charged multivesicular body protein 2a
- Vacuolar protein sorting-associated protein 4B
- Vacuolar protein sorting-associated protein 4A
- Charged multivesicular body protein 2b
- IST1 homolog
- Charged multivesicular body protein 1B1
- Charged multivesicular body protein 5
- Charged multivesicular body protein 4c
Sequence:
MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALQQKNVECARVYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSAMDLQKVSAVMDRFEQQVQNLDVHTSVMEDSVSSATTLTTPQEQVDSLIVQIAEENGLEVLDQLSQLPEGASAVGESSVRSQEDQLSRRLAALRN
Protein: Protein transport protein SEC23 A (AtSEC23A) (Protein transport protein SEC23/SEC24-like 2) (AtSec23/Sec24L2) (Q84WV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (By similarity). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). May contribute to COPII-coated vesicles formation and ER-Golgi vesicle transport. Together with SEC23D, essential for pollen wall development and exine patterning, probably by regulating endoplasmic reticulum (ER) export of lipids and proteins (e.g. sporopollenin) necessary for pollen wall formation. Also involved in plastid physiology in anther tapetal cells.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:29390074}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15303}; Cytoplasmic side {ECO:0000250|UniProtKB:P15303}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:29390074}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15303}; Cytoplasmic side {ECO:0000250|UniProtKB:P15303}. Membrane {ECO:0000250|UniProtKB:P15303}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15303}; Cytoplasmic side {ECO:0000250|UniProtKB:P15303}. Note=Observed at endoplasmic reticulum exit sites (ERESs), characteristic for COPII-coated vesicles localization. {ECO:0000269|PubMed:29390074}.
Interaction partners:
- Protein transport protein SEC24 C
- Protein transport protein SEC13 homolog B
- Protein transport protein SEC31 homolog B
- Protein transport protein SEC31 homolog A
- Protein transport protein SEC24 B
- Protein transport protein SEC23 D
- Protein transport protein SEC24 A
- small monomeric GTPase
- Protein transport protein SEC13 homolog A
- Small COPII coat GTPase SAR1B
Sequence:
MANLPKSSVNYPGTLTPLEPNRPSPQPDRTPVPHSPPVVASPIPPRFPQPSFRPDQMSSPSMKSPSLLSPANGIRTGSPIPRLSTPPGPPVFNTPVKPAAVPFRTSPATPQPMAYSSANSSLPVSTPSFYSNGSSVGSQRDLPDVVRMEEPIAADSPYVLFSANKVLKQKKLANVASLGFGAIVSAGREISPGPQIIQRDPHRCLNCGAYSNPYSSILIGSGQWQCVICENMNGSKGEYVASSKNELQNFPELSLPLVDYVQTGNKRPGFVPASDSRTSAPVVLVIDECLDEPHLQHLQSSLHAFVDSLPQTTRLGIILYGRTVSIYDFSEDSVASADVISGAKSPSAESMKALIYGTGVYLSPMHASLKVAHEIFSSLRPYTLNVPEASRDRCLGTAVEAALAIIQGPSAEMSRGVVRRAGGNSRIIVCAGGPITYGPGSVPHSMSHPNYPYMEKTAIKWMENLGREAHRHNTVVDILCAGTCPLRVPILQPLAKASGGVLVLHDDFGEAFGVDLQRAATRAAGSHGLLEVRCSDDILITQVIGPGEEAHSETHETFKSDAALSIQMLSVEETQSFSLSMENKRDIKSDHVFFQFAFHYSDVYQADVSRVITFKLPTVDSISAYLQSVEDEASAVLISKRTLLLAKNQKDAVDMRATVDERIKDIALKFGSQVPKSKLYSFPKELSSLPELLFHLRRGPLLGNIIGHEDERSVLRNLFLNASFDLSLRMVAPRCLMHQEGGTFEELPAYDLSMQSDKAVILDHGTDVFIWLGAELSADEVKSAAVLAACRTLAEELTEFRFPAPRILAFKEGSSQARYFVCRLIPAHKDPPYEQEARFPQIRTLTTEQRMKLKSSFIEFDEASFCEWMRSLKVVPPEPR
Protein: 3,5-dihydroxyphenylacetyl-CoA synthase (EC 2.3.1.246) (3,5-dihydroxyphenylacetyl-CoA synthase polyketide synthase type III) (G4V4T4)
Organism: Amycolatopsis orientalis (Nocardia orientalis)
Function: Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. Catalyzes the Claisen condensation of four molecules of malonyl-CoA to yield 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) and three free coenzyme A (CoA). DpgA requires the presence of the dehydratases DpgB and DpgD to facilitate the aromatization of the DPA-S-DgpA or DPA-S-CoA intermediate.
Interaction partners:
- Enoyl-CoA-hydratase
- 
- Enoyl-CoA-hydratase
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit omega
- DNA-directed RNA polymerase subunit alpha
- 6-deoxyerythronolide-B synthase
- 6-deoxyerythronolide-B synthase
- 6-deoxyerythronolide-B synthase
- 6-deoxyerythronolide-B synthase
Sequence:
MDVSMTTGIELTEELSVLNGLTEITRFAGVGTAVSETSYSQTELLDILDVEDPKIRSVFLNSAIDRRFLTLPPENPGGGRLAEPQGDLLDKHKKIAVDMGCRALEACLKSAGATLSDLRHLCCVTSTGFLTPGLSALIIREMGIDPHCSRSDIVGMGCNAGLNALNVVSGWSAAHPGELGVVLCSEACSAAYALDGTMRTAVVNSLFGDGSAALAVISGDGRVAGPRVLKFASYIITDAVDAMRYDWDRDQDRFSFFLDPQIPYVVGAHAEIVVDRLLSGTGLRRSDIGHWLVHSGGKKVVDAVVVNLGLSRHDVRHTTGVLRDYGNLSSGSFLFSYERLSEEDVTRPGDYGVLMTMGPGSTIEMALIQW
Protein: Enoyl-CoA delta isomerase 3 (EC 5.3.3.8) (3-hydroxyacyl-CoA dehydratase 1) (Delta(3),Delta(2)-enoyl CoA isomerase 3) (AtECI3) (O23300)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Essential for the beta oxidation of unsaturated fatty acids.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18657232}. Nucleus {ECO:0000269|PubMed:18657232}.
Interaction partners:
- Enoyl-CoA delta isomerase 2, peroxisomal
- Enoyl-CoA delta isomerase 1, peroxisomal
- Serine/threonine-protein kinase ATG1t
- Proline-rich extensin-like family protein
- Serine/threonine-protein kinase BSK
- Uncharacterized protein unannotated coding sequence from BAC F9L11
- Proline-rich extensin-like family protein
- DNA polymerase epsilon catalytic subunit A
- At5g48370
- Proline-rich extensin-like family protein
Sequence:
MCTLEKRGDLFLLTLTGEDEHRFHPDTIASVLSLLEQAKSQSTKGSVLITTGHGKFFSNGFDLAWAQSAGHGAIKRMHQMVKSFKPVLAALLDLPMPTIAALNGHAAASGLMFALSHDYVFMRKDRGVLYMSEVDIGLPVPDYFSALVVAKVGSGIARRELLLSGKKLKGEEAVALGIVDSAAHDSAEGVVEATVSLGESLAAKKWNGEVYATIRKSLYPELCRMVDLTANNLATHNL
Protein: Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 7.1.1.8) (Complex III subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) (Q09154)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P08067}; Single-pass membrane protein {ECO:0000250|UniProtKB:P08067}.
Interaction partners:
- Cytochrome c oxidase subunit 13, mitochondrial
- Cytochrome b-c1 complex subunit 10
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c oxidase subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome b-c1 complex subunit 7
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome c oxidase polypeptide 5, mitochondrial
- Cytochrome b
Sequence:
MLAKQFISKSLASSLRRLLPVSSTASSLKGSMMTIPKFTSIRTYTDSPEMPDFSEYQTKSTGDRSRVISYAMVGTMGALTAAGAQATVHDFLASWSASADVLAMSKAEVDLSKIPEGKNLVVKWQGKPVFIRHRTPEEIQEANSVDISTLRDPQADSDRVQKPEWLVMIGVCTHLGCVPIGEAGDYGGWFCPCHGSHYDISGRIRRGPAPLNLAIPAYTFEGSKIIIG
Protein: BPTI/Kunitz inhibitor domain-containing protein (A5A8R2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHLFLLFIPHVIAVKDLAWYSANPVLSSSHPVGPAAIQAATAIDFCQLPVDTGKCSQQLVRYYYDAAVDECKRFTFSGCGGNSNRFMRRAHCRNRCVKQPNKPEVQELKHRRTVTSTTSTPFQTVNEESTVEPSATKRLPVTLPVKKLELVQSGHGNGLCQDCDPLYGTCLDGKCGCMKGFRSLGKVCIDLNECDNGAVCGPNARCVNEIGSFQCVCDAGFSTDGDCKIGQEACMDEFDVNLTEEDCNNGKQEIK
Protein: Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) (P39023)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16963496}. Cytoplasm {ECO:0000269|PubMed:16963496, ECO:0000269|PubMed:23636399}.
Interaction partners:
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL20
- Elongation factor 2
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL21
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL22
Sequence:
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
Protein: Mammalian-like melanopsin (Melanopsin 2 isoform L) (Q2KNE6)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}.
Interaction partners:
Sequence:
MDLPPRAPTKMTVKDVRGAFPTVDVPDHAHYTIGTVILIVGITGTLGNFLVIYAFCRSRTLQKPANIFIINLAVSDFLMSITQSPVFFTNSLHKRWIFGEKGCELYAFCGALFGITSMITLMVIALDRYFVITKPLASVRVMSKKKALIILVGVWLYSLAWSLPPFFGWSAYVPEGLLTSCSWDYMTFTPSVRAYTMLLFCFVFFIPLIAIIYSYVFIFEAIKKANKSVQTFGCKHGNRELQKQYHRMKNEWKLAKIALIVILLYVISWSPYSVVALVAFAGYSHVLTPFMNSVPAVIAKASAIHNPIIYAITHPKYRTAIATYVPCLGFLLRVSPKESRSFSSYPSSRRTTITSQSSETSGLQKGKRRLSSISDSESGCTDTETDITSMISRPASSQVSYEMGEDTTQTSDLGGKPKVKSHDSGIFGKAVVDADEIPMVEINDTEHSATSTCKTSEKCNVEEIQRSESLSGIGLREGESRRRTSASQIPSIIITYSNVQGVELPSGYSAGFLHPKNKSHIQNKSSNS
Protein: Uncharacterized protein (Q57TZ5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGKRRRSIGELPDETGFNGDNRGDIDDVEAGDVMEHILEEGEEEMDDDCEDDDDEPTGTGSSPPSLGAYIWGEVSMALYVSMLKQLHHICGCIAIQPSSEERRKLIAKARTQTKALWDLEMLSSDSSEQEDLAEYFHSQISSLLDNVTSLAESDMKAGELCQAFLQTLNMFGFPEEENLDEVQLQANIRKSAELQCYSYQQRTSNQLNVLRRYEGDRRSEDQYLQPRVGRIVRFPIPHPHEEVNTRIQLIEPKRRRPPLEENRICSHPKRATAFGMEDVLVDEELQFRALVMLGRHLDTFCSIQHISPYLRLTVWNLLDRDEEIFERLCEVPKGDDDTAVHLQLLTELRQRVARKRMAFESTRVGARECVARLTWSAVSARWRDQVLCAVEEVEDADWCLLRDSAKVGTRAIFPNYAVCSAVRDIALKALRRVRDGTIDCGGIDDAADCYEVIARVLVPILEGGQPMFPMDDTSDSDGEREREACRKKEPRGKAQRPFHYGELCQRFATLMSRGEDAELTDTKVARSVRWNLNCETLLAEEGVVCTFLTGMFVWPLQCLASFLELVAAGRHSVDGLRKFSAAFIPSNWSDERGVLEYLLRREPTNLPLTAFVAFPRLIRDVYISARWLLNDKCFAAVVACRREACKLPSNKPAINFIQWKALSSVLAEVGYKDELLALTVRGALPSDADEGKLWSVAELQHTVRAWIDGVELMLLAEKSAMVSGATSATGTAFVVGRSDSKSDGEG