Protein: Zinc finger protein sdc-3 (P34706)
Organism: Caenorhabditis elegans
Function: Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Plays a central role in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Involved in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reduction of X-linked gene transcription and an equalization of X-linked gene expression between the sexes.
Subcellular location: Chromosome {ECO:0000269|PubMed:11937488, ECO:0000269|PubMed:14660541, ECO:0000269|PubMed:9056777}. Nucleus {ECO:0000269|PubMed:9056777}. Note=Localizes specifically to X chromosomes in hermaphrodite (XX) embryos after the 40-cell stage. {ECO:0000269|PubMed:11937488, ECO:0000269|PubMed:14660541, ECO:0000269|PubMed:9056777}.
Interaction partners:
- Sex determination and dosage compensation protein sdc-2
- Dosage compensation protein dpy-30
- Zinc finger protein sdc-1
- Lysine-specific demethylase 9
- Chromosome condensation protein dpy-27
- Condensin complex subunit dpy-26
- Mitotic chromosome and X-chromosome-associated protein mix-1
- Condensin complex subunit 1
- Condensin complex subunit capg-1
- Protein her-1
Sequence:
MSDEPPIVLPTEEDGPFSNCVSIAFVNDKSIPVELRIRKAIRGKVTFTQELVVAARRLYLDGELERPDLNYHVAADFYDPFMIPVPDHRNWEYNPLYPREWPRLIDRDLVQKIKMSNTYKKNQARRKRRRLLRIFHRKRGGEFLNYLWHSKENDVHYKRYMAAYQFPLPFEKCIRDVVREELKDPETSFSKPPSVVHHSKIRPATPDLLKLAKYLGKDRFCFIVTPFKFRSQFRLRYYKKSPFKRSNILEKWLKFKKVRDQGVFNIRDAAREVKKLLQRKNVYHMTDPQCEQEFWDVYRLQMQWLEEDNIEENITMLRENLSKVTDEEFNRSVYIMRPENRASIHDDVTFTTDAEINLKPIVLELFRNNMPLEDIRQVKECIDDMINLTVCQELIPQVATIETVRDYSGVEQHRLKYIRPENELEIMFQLATVLVKNENTHDQEITSPMFALLRTEQYLWSIPLRPFLRMYTDWRKTKLNFKKFRKFSPELVSKAPIDLFKVFLTTNMDKKGVATKDTDCFDYRTASEIKKLYHEEFIRVRPIIEHQRFHRCYTSVITEEPLPNPFYWVHRGQWEKVYECNWKQRVKPLAGRFSWKTKHPNICDLPRLEKDDKQEMEMLAKMREKIREYNKEKEKHPFYVSSSLPEFASTSDFVKFPISNTGIKYTAPRRNQPKVQRSLVTYTRFRLAELEDKDFSFPEEKMLEKNRLLEKLNFEERLQLDALMSKDVKYKPRMIPEKGFLQLQDEKLILKRLCEKEDEWSGKQKRRFPDLYEQATQEAERLGDPDASTSGTSNKELGLLPVWKHDDFRDLKKINVLGSKEYPISSPYLIKRLHYDIHLEIVRDKLKSWIYRTELWEKMKPVYERLKRDKEKREKEWHEMRAAQRAQKEKEEEDQRRMDMGIEHGQESLLKSITPEVEQQILLPISRENSFEEMLPAPQEAYDEDLDQDIDIHFDGAESVCTGIRLDSEDRELVDSPDQVENEEPERVEAVTENIRQEMSDAEMRDLMRKKREQYSMLFPNVPQPFQPLNRFDVTAPGAGIVPPYDEAPDFDLSAYLEEDHVRIPTLSTVEINSLLKDQDLVEEQEIVEEEETPLVVEEPDIPAAPVLSAEEKASRISREMSALRKLPDAAFNYASDRDGVVVEEVETIEEIQEIYNDKLEKMIAARLGSIAQGANIERLSEDQLLGDQGSEDISFEEIQVDLLLESGVEVQVNQSVTISRSSTSFESLLVEDPEEHPEQLPVSASEKANNQIVPEVEVEGSVVPVTNQQEENVTSEGPTLQEGSSIPSSSHIYTVDELLGTESPGPEATETPVAEESPKKKSGKTTRGRPKKVKENLKKRIQPRRGQKEEAAHEPEVVEEQEQVEPEVGPEVVHEPVPAPAAQLETEPIEQQIEEPDKVFEPIIEALPLFETSPVPAPEGNIPSRAHSSDDDVQVISSETDPNGPINLVEQVQNDKLTAYQYSTEELLGEYGELDEAGAPSPSEIVVHDEVLQDEVLQPNPKSSKKRGRRRKKTPPHIAKARKVFTSISKTEEIELAPTPTQQSRKRMANVSSEEATATRRQKRAKVEEPNDSDVSRVLTPEPEDLHETERPGHVGEEGFETPSLRTGRESTASSVKTSRSKRLFLSKNNPVPRMRIQSQAGTNASPTPARRTGVARDSVSPDGASEKLKQLPKSVQDIFEVFDVERSAERGESATVTNLEGPVKIEIEDENWMAPPAITETSRKSKKRLRAEKQQQILDDIKLELNGEPPQKRECEILMERVQVKIEEGVENADCRIVQANFNCKSVEEHETLPLKIIRVFEENEKPVHKFFMTQIIWKEINEAFMTDPEKFMLLVRILFSDRNISGQIYKISMTVTDRIKGFDDDFIKLLTQFPKKLSQEHKPLVDYNKLAHALREKASLHLNNHKITPFTFHGVISNITEMKEKIIGRCEIGMLTDGDRDVLNSTENMLLGAYMKSVLRMTAQSQVSWAHPEYIKRRLEMIYYGWRMFLGSGGFFRVALAINRKDVKPMSQQFRDFFIEYLKDVNENYAKAVELVQMDEDKLMEAMIEKAGLSSIDLLALDEDVQGQVSESHKHKCVQCSIRNQSVYFSSYSLLELHGKLHQNLHELAPEDADDCQDCYETLTSSFEVIVHRINHHHSRRCFFADD