wanglab/gogpt-training-data huggingface dataset:
Protein: GH84 domain-containing protein (OGA-1b) (Q1WBU8)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MEQTESFDRRKAVQNSKYICGVVEGFYGRPWTPEQRKHLFKRQNQLGLTTYLYAPKDDIKHRSLWRELYNNEEMTYLRNLVESAKDNNVNFVYAISPGKDILYSSDEEMDTLKNKLDQVRSVGCDSFAVLFDDIEVQMQDEDQKQFTSFAHAQVHIANTIFKYLNTKTFMFCPTEYCESRAVPTLESSQYLNTIGEQLAGDIHIMWTGPRVISRYLTVEHLARVGSVMRRKPLIWDNLHANDYDLKKIFMGPMMHRSVKIKEFTSGLLSNPNGRYEANFVPFHTLSDWNAADRDLRENESGISSRNGVILNIDCNTETIYVPEVSLVNAVSTWIDEFITPSVTNAPQPPQLTADVAGYVPDRRECVWLLDLPETHGVIRPEPVMPAEIATENIIQSAVAPEEPVPSELNSLAAEYSQPMETEDPVESQEDESMVSVDEDVSAPVVLPGLATTAEEIRNQRLSLLCATCEMYYLPFENGPRVQSMFKDFRWLMQNASVMKKSFKEIETLDPLQSEWLVKYDGVNEFLTSAIDSFFFITQAPNKAILSEIVPYAFDAHSCCVLLIAVARWMMQGNALDNPENNLFEDFGSTEERWINQNGFRSETMRVLNVVDDIEVLLSNKIFLPLCMFCFDIRPFTIADKEYISGMVTVMLTTNQELLHRRATNFADRNIIPFLCSGAEHNFLCEKVDETGHKPVCYASAHFDGTLFSNFLITYKEKLKEKYRGLIEDSKIGSTKLTDEYIEFIQNSQTPMDIEEWYPKIPDQIFENYPAWVETYFGMDASDAHPMRKVIQVVAVTLAMNGSRGYFLTVAIDDIERQKYFLELGLTDLGLSICQRFRIFGQTLRSTSRQSSTSE
Protein: PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (GLUT1 C-terminal-binding protein) (GLUT1CBP) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Q9Z254)
Organism: Rattus norvegicus (Rat)
Function: May be involved in G protein-linked signaling.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O14908}. Membrane {ECO:0000250|UniProtKB:O14908}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Unconventional myosin-VI
- Regulator of G-protein signaling 19
- Plexin-D1
- Neuropilin-1
- DCC-interacting protein 13-alpha
- Syndecan-4
- Vascular endothelial growth factor receptor 2
- Low-density lipoprotein receptor-related protein 2
- Trafficking protein particle complex subunit 4
- Rho guanine nucleotide exchange factor 12
Sequence:
MPLGLGRRKKAPPLVENEEAEPSRSGLGVGEPGPLGGSGAGESQMGLPPPPASLRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPAAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEDALGLTITDNGAGYAFIKRIKEGSVIDHIQLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSSGGHPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY
Protein: Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1) (Q9NY26)
Organism: Homo sapiens (Human)
Function: Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11301334, ECO:0000269|PubMed:11696349, ECO:0000269|PubMed:16844077}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11696349}; Multi-pass membrane protein {ECO:0000255}. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines. {ECO:0000269|PubMed:11696349}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A1
- Probable proton-coupled zinc antiporter SLC30A4
- Probable ATP-dependent DNA helicase HFM1
- Zinc transporter SLC39A7
- Meiotic recombination protein SPO11
- Natural resistance-associated macrophage protein 2
- Ferroportin
- MutS protein homolog 4
- Protein SPO16 homolog
- Metal cation symporter ZIP14
Sequence:
MGPWGEPELLVWRPEAVASEPPVPVGLEVKLGALVLLLVLTLLCSLVPICVLRRPGANHEGSASRQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALAALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSGPSPLEETRALLGTVNGGPQHWHDGPGVPQASGAPATPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHKGILAVSLSLRLLQSHLRAQVVAGCGILFSCMTPLGIGLGAALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELASSEQRILKVILLLAGFALLTGLLFIQI
Protein: Zinc finger protein ZPR1 homolog (O16999)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Elongation factor 1-alpha
Sequence:
MAADSQDIYRNLSADDYEAAPIVVDSVCPVCEEDGETRIMCTSIPYYRAVILMSFECPHCGHKNNEIQSGEAVQEHGTLIVLRVQKPEDLRRQLVKSEYASIEVPELQLEIPHKSQPGEVTTVEGVLERVHRGLSQDQEKRRLLDPEGASQIDAYLQKITSCMELGETWTLRLRDPTGNCYIQNPDVRHVDPRCIISHYHRNLDERKLLALADDNEEEEEVEPSAAAPEFKSYEDAKQEVLHFATDCPNCHGPTEVKMKPTDIPFFQTVIIMSLACDRCGYKSNEVKSGGAIRDQGCRMSVKLEKDLDLARDVLKTDTCALSIPEIDLEVGGNALCGRFTTIEGLLTATKEQLDAQSSFFMGDSAQTGEKSAVTTFLEKLDDIIALRLPATIILDDPTGCSYVQSLTAPMDDPRLTKEFYTRTYEQNDELGINDMKVENYGELDALAEEDEPHEA
Protein: Bile salt hydrolase (I3QNS8)
Organism: Bifidobacterium animalis subsp. animalis
Interaction partners:
Sequence:
DDGQNNMYFGRNLDWSEDYGEKIVFAPHDYHYTPAFNAEDKNHPVIGIGIIVEDTPLYFDCMNDAGLAVAGLNFAKYCKYATEAVNFTTNVAAYEFPLWVTRNFTSVDDVQEALKNVTIVGKPINDRFPVATLHWIIADNTRSIVVECTEDGMHVYDDDV
Protein: RNA-binding motif protein 14b (A0A0R4IJ04)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDKGHTVKLFVGNLALDTTQEELSAIFESYGQVVSCSVLRQFAFVHLQGEGAAERAIRELNGREFKGRNLVVEESRGRPLHSTKVFVGNLSSMCTTEDLQELFQTFGKVLECDKVKGYAFVHMENKEDALQAIEALHGTSFKGRPLSVELSKVQPSKQTPTGKIPCVSCGKQGHYAGECPAGKPTLEQYQSQAAVLAAAAAAAAGLPLQVQQSVHNSVYNTSTFDPTYAALTGLTAAGARAEGGAAVAPAVYGALASQVYGTAVANQLYGGSVANQALNSSAAAAAAQAYGTVNPALYGQMTSGAVAAAAAAAAAYGPQVYTQAVGNPVFLTAAPSMEVPAGAAAVNPAYTVAPALYSATPAYGALGAADPAAIFEAARAHYFAQGQQVLAEQQQASSKSGERDRSPLRRSAPLLPDPVMKPFIYQRAKRRALLPTPAGREEAAAQEDDPVARYYAEYYQQYQQLQQYPQYQYAYPAHSALAAMSALQSLPGVSAQQVATLDSLRPVLPAAPVPAAAAIAMATPRVYEPPPIPPSHKEPLLRRPELALHTPETPFR
Protein: Translation factor GUF1 homolog, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase GUF1 homolog) (Ribosomal back-translocase) (Q38BU9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03137}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03137}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03137}.
Interaction partners:
- Ribosomal protein
- 40S ribosomal protein S13, putative
- 40S ribosomal protein S5, putative
- Small ribosomal subunit protein uS5
- 60S ribosomal protein L5, putative
- Large ribosomal subunit protein uL5
- 40S ribosomal protein S23, putative
- 60S ribosomal protein L17, putative
- 40S ribosomal protein S15a, putative
- 40S ribosomal protein S14
Sequence:
MRLWNRFSRLGNLLCACAACGCSFTPWRCSSSPLLSSFSAYNMSSGNRVTSSVGGSSGATEVCPSHTPLSSSTLLRYTIAPSEPTMGSPWQTSEESASRRLAALTSYPPSNIRNVAVVAHVDHGKTTLSDVLLRRTGVLKGSVNAGAYTDRLLVERERGITVKSQTCSMFLKYGGSEFLLNLIDTPGHVDFQYEVSRSVRAAQAVLLLVDVAQGIEAQTMSHFHMALDQGLAIIPVFTKMDCVLNDTTVDAALQQLEDSTGLLRSEVVFTSAKEQLGVEALLQAIIERVPSPSGAIGLSDVCQLPPLLPGSTARVAMEAEMVPLRAILLDSWTRECGGGLYRPPSKTSSALSGNVKIDEDKDTVTCLVSVIDGTLTARTNILLYHSQKRYEAREVGVIHPELRPTGALTVGMVGYVVFTRVQREDFSVGETLYTLPTRKFTRGGIAPVPGFRRVHPVVFAGFYPDEGEYVTQLREAVEKLRMNDPAVTVEPLECQALGSGLQLGFLGVLHMQIFQERLLSEFGQRVLVTPPVVQYKYREAAGGDDQPPKPLSVHTWRWLHEGVSCYMEPHVTATVVTPSEYAQIIDGEAQRHYRGKQLDMRVMDDARVLLRYKMPLADMVRGFFTFVKSQSHGYASLEYDELVYEEADLVRVDIVVQKARISALAVICPRHEAPSVGKRIVASLKSNLTRTAVDIPLQALVGSKVVARETVRAYRKDVTAKIHAGDISRKQKKWNDQKKGKERMARRTVGGVTLDQSVLAAAMGATAL
Protein: Vacuolar protein sorting-associated protein 28 homolog (Q548N1)
Organism: Homo sapiens (Human)
Subcellular location: Late endosome membrane {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004633}.
Interaction partners:
Sequence:
MFHGIPATPGIGAPGNKPELYEEVKLYKNAREREKYDNMAELFAVVKTMQALEKAYIKDCVSPSEYTAACSRLLVQYKAAFRQVQGSEISSIDEFCRKFRLDCPLAMERIKEDRPITIKDDKGNLNRCIADVVSLFITVMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWLQTLSGMSASDELDDSQVRQMLFDLESAYNAFNRFLHA
Protein: Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit beta-1) (K(VCA)beta-1) (Maxi K channel subunit beta-1) (Slo-beta-1) (Slo-beta) (Slowpoke-beta) (P97678)
Organism: Rattus norvegicus (Rat)
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Calcium-activated potassium channel subunit alpha-1
- Calcium-activated potassium channel subunit beta-4
- Intermediate conductance calcium-activated potassium channel protein 4
- Small conductance calcium-activated potassium channel protein 1
- Small conductance calcium-activated potassium channel protein 3
- Small conductance calcium-activated potassium channel protein 2
- Potassium channel subfamily U member 1
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Calcium-activated potassium channel subunit beta-3
Sequence:
MGKKLVMAQKRGETRALCLGVAMVVCAAITYYILGTTVLPLYQKSVWTQESTCHLVETNIKDQEELEGRKVPQYPCLWVNVSAVGRWAMLYHTEDTRDQNQQCSYIPRNLDNYQTALVDVKKVRANFYKHHNFYCFSAPQVNETSVVYQRLYGPQILLFSFFWPTFLLTGGLLIIAMVKLNRSLSVLAAQK
Protein: Helix-loop-helix protein 17 (O45489)
Organism: Caenorhabditis elegans
Function: Probable transcription factor that regulates the expression of dopamine receptors dop-1, dop-2 and dop-3 and thus dopamine-dependent behaviors. May act redundantly with hlh-31 and hlh-32 to regulate ventral CEPsh glia functions. May play a role in chemotactic responses in larvae.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- SSD domain-containing protein
- Paired box protein 6 homolog
Sequence:
MEKIGIDTAFAEPGVRLSINLRERCRMHDLNEALDDLRAVIPYAHGGSVRKLSKIATLLLAKNHIIMQAKAIEELSILVSQLKRKSENLENLNKSLKPDAN
Protein: UDP-glycosyltransferase 84A1 (EC 2.4.1.120) (EC 2.4.1.177) (Hydroxycinnamate glucosyltransferase 2) (AtHCAGT2) (Q5XF20)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: UDP-glucosyltransferase that forms glucose esters with phenylpropanoids. Glucosylates 4-coumarate, ferulate, caffeate, sinapate and cinnamate. Can glucosylate the phytotoxic xenobiotic compound 2,4,5-trichlorophenol (TCP).
Interaction partners:
- Peptide transporter family protein
- Uncharacterized protein At5g19190
- Malonyl-CoA:anthocyanidin 5-O-glucoside-6''-O-malonyltransferase
- At5g43870)
- Tagatose-6-phosphate ketose/aldose isomerase, putative
Sequence:
MGSISEMVFETCPSPNPIHVMLVSFQGQGHVNPLLRLGKLIASKGLLVTFVTTELWGKKMRQANKIVDGELKPVGSGSIRFEFFDEEWAEDDDRRADFSLYIAHLESVGIREVSKLVRRYEEANEPVSCLINNPFIPWVCHVAEEFNIPCAVLWVQSCACFSAYYHYQDGSVSFPTETEPELDVKLPCVPVLKNDEIPSFLHPSSRFTGFRQAILGQFKNLSKSFCVLIDSFDSLEQEVIDYMSSLCPVKTVGPLFKVARTVTSDVSGDICKSTDKCLEWLDSRPKSSVVYISFGTVAYLKQEQIEEIAHGVLKSGLSFLWVIRPPPHDLKVETHVLPQELKESSAKGKGMIVDWCPQEQVLSHPSVACFVTHCGWNSTMESLSSGVPVVCCPQWGDQVTDAVYLIDVFKTGVRLGRGATEERVVPREEVAEKLLEATVGEKAEELRKNALKWKAEAEAAVAPGGSSDKNFREFVEKLGAGVTKTKDNGY
Protein: P-selectin glycoprotein ligand 1 precursor (Selectin P ligand) (p-selectin glycoprotein ligand-1) (G4WJE8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Selectin P
Sequence:
MAAMVAYKLGCLSVLVLLLTLSSTVTSRSLRMEREINPNITSKNNTEMQSPSTVAEAEKNMTITIKTPVQTVNVTPKSNVSTVTDYHHTQQNTSAGTGNLTVHPPAEKEISLHTQPPTTNNSTGHIAQAGSSAPTFSPTSVPIKVTEKPTTTDKSSSHVSTTTRKSSTVTTHSCPTAISKQNGLVSRCLIAIASMAALTTIFIISTICLATKLSAYRYRHKAHLLQETEMVCISALMNDTDHPVPKPRRHPKSNGALIPNAEDGDPDGDDLTLNSFLPDTEGPL
Protein: Nitric oxide synthase oxygenase (EC 1.14.14.47) (NOSoxy-like protein) (O34453)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the production of nitric oxide.
Interaction partners:
- Bifunctional cytochrome P450/NADPH--P450 reductase 2
- Argininosuccinate lyase
- Arginase
- Arginine decarboxylase
- Uncharacterized metallohydrolase YodQ
- Sulfite reductase flavoprotein alpha-component
- Argininosuccinate synthase
- Ornithine carbamoyltransferase
- Bifunctional cytochrome P450/NADPH--P450 reductase 1
- Ferredoxin--NADP reductase 2
Sequence:
MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATNNGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLWKDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE
Protein: Cutinase (EC 3.1.1.74) (Poly(ethylene terephthalate) hydrolase) (PET hydrolase) (PETase) (EC 3.1.1.101) (Q47RJ6)
Organism: Thermobifida fusca (strain YX)
Function: Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Shows esterase activity towards p-nitrophenol-linked aliphatic esters (pNP-aliphatic esters). Also hydrolyzes the triglyceride triolein (Probable). Capable of degrading the plastic poly(ethylene terephthalate) (PET), the most abundant polyester plastic in the world.
Subcellular location: Secreted {ECO:0000250|UniProtKB:G8GER6}. Periplasm {ECO:0000250|UniProtKB:G8GER6}.
Interaction partners:
Sequence:
MAVMTPRRERSSLLSRALQVTAAAATALVTAVSLAAPAHAANPYERGPNPTDALLEASSGPFSVSEENVSRLSASGFGGGTIYYPRENNTYGAVAISPGYTGTEASIAWLGERIASHGFVVITIDTITTLDQPDSRAEQLNAALNHMINRASSTVRSRIDSSRLAVMGHSMGGGGTLRLASQRPDLKAAIPLTPWHLNKNWSSVTVPTLIIGADLDTIAPVATHAKPFYNSLPSSISKAYLELDGATHFAPNIPNKIIGKYSVAWLKRFVDNDTRYTQFLCPGPRDGLFGEVEEYRSTCPF
Protein: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (Q9N4Y8)
Organism: Caenorhabditis elegans
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 4
- Acyl carrier protein
- NADH-ubiquinone oxidoreductase chain 4
- Cytochrome c domain-containing protein
- NADH-ubiquinone oxidoreductase chain 3
- Complex I-49kD
- NADH-ubiquinone oxidoreductase chain 1
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MHRVGGQIVRGVSKAQQKRSLSVAAPAPPKKVEVFIDDKKVLVDPGMTILQACALVGVDIPRFCYHDRLSIAGNCRMCLVEVEKSVKPVASCAMPVMNGMKVKTNSDFVKKAREGVMEFMLNNHPLDCPICDQGGECDLQDQAMNFGSDRGRLQSRFDGKRALEDKNIGPLVKTVMTRCIQCTRCVRFANEVAAFPDFGTTGRGQDLQIGTYVEKFFASELSGNIIDICPVGALTSKQYAFTARPWETRKTESVDVMDATGSNIVLSHRTGELLRVIPKINDDINEEWIGDQSRFAVDGLKVQRLLTPMIRGADGQLKPATWEEALFTVAAKLRETPAEQKAAVAGGLNDVESLVALKDLFNRFNSENVMTEEEFPDVGSGGSDLRSNYVFNDGIASVENADAILLVGTNPRFEAPTLNARIRKSFLYSDVQVGVIGAETELTYEYDYLGASAKAIDEILAGKGDFAKILSSATTPLIIVGAQALKGEAGAALLGKLQQLADKLGSGKEVKVLNVLQRWAGQAGALDVGYKAGTAGIRKTPIKFLYLLGADEGKVTKANLDPSAFVVYQGHHGDAGAEMADVVLPGAAYTEKEGTYVNTEGRSQRAYPAVSPPGDARVDWKIIRAVSEVSGKSLPYSDLKEIRQRLNEIAPHLVRYRDLEASPFVKQALQLAQPTGSIDVDVSPVLRELSDYYQTNVISRYSRSMAQARKAAIENKTNPYAEEPVYARL
Protein: RIC3 acetylcholine receptor chaperone, isoform N (E1JGP2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Interaction partners:
Sequence:
MPATATSKPRAPLVEEGMTPKKTALIIVTVIGCIAILWPKVFHPMMFGGVPPSQPNFKDPRAAPGGCCDVVLDREQFLNATKKDTVEPFGPHLYRKQINVYTGEISLRQERPAHLHPESIYQAMRERGRAIPATPTVPILERKTSPSNPPPRIVDGRPGPIPGMRPPMGAGALHQPQQRGSSMGFLMPLYTIGIVVFFGYTLMKIMFKKQVPNDPYGAAPPNPAFRQEVFGSQNHSQVEDLGGSKLGAATATAAAKKPAAKDTEKELYNASVSATEVASSLSASLKSHQQLKEAEQLMEIEKLRQKLESTERAMAQLVAEMNTDQYEAKKNDNEKTREQPLDKQNLSNGHASSTDQNPEQETVAKGARKRRDLSAEQELTSKLEDNLPEPQSIYLEGALAHESQILVADSQIKREEVYDSELNGSAEEPAIILSSRMTLSLINLDANQQNGNAGKSAVESPLADDIEIIGHDEQ
Protein: Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger) (Solute carrier family 24 member 1) (Q9QZM6)
Organism: Rattus norvegicus (Rat)
Function: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q28139}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Potassium voltage-gated channel subfamily V member 2
- Phosphodiesterase
- Rod outer segment membrane protein 1
- Cyclic nucleotide-gated channel alpha-1
- Phosphodiesterase
- Cyclic nucleotide-gated channel alpha-3
- Photoreceptor-specific nuclear receptor
- Regulator of G protein signaling 9 binding protein
Sequence:
MGKLIRMGTQERRLLRPKRLHWSRLLFFLGMLIIGSTYQHLRRPQNPPSMWTKVSSQQPIKLAIRDLPNDEITVTDKDPPEASSEVEGEMLAPQDTVIIGEAAPSIAMEDTPNPPITTKITPTSLKNNYSPTTAGTRRQKENIPPTPSRAPSHFISTSGRQRVKSYTPKPRGGRKSSSPTHTREEGRMHTPSPAGAPRTISPTSTEKDSETTATYRMLEPRSERTAGKTSLKRMVPNTRTFLTREVETDLVTSPSLVGKNTLGSPRRGERNSSTTPLRAVLQPTPATSEEQVTASIRMGSTPATTEGSTAAQRIGNPLSGTSTPAVRIASVTDREKRPSTAHGTLVTPQVKAVLTTQVHRCVVVKPAPAVPMTPSPSMTAILFPEAPTSGPSALPPGWPNLHPKAEYPPDLFSVEDRRQGWVVLHIFGMTYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLSMLIVFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIERWVKEQLSRRPVAKVMALGDLSKPSDGAIEENEQQDNKKLKLPSVLTRGSSSASLHNSIIRSTIYHLMLHSLDPLGEARPSKDKQESLNQEARVLPQTKAESSSDEEEPAELPAVTVTPAPAPEDKGDQEEDPGCQEDVDEAEHRGDMTGEEGERETEAEGKKDEEGETEAERKEDGQEEETETKGKEKQEGETESEGKDEQEGETEAEGKEADHEGETEAEGKEVEHEGETEAEGTEDEQEGETEAEGKEVEQEGETEAEGKEVEHEVETEAERKETNHEGETEAEGKEADHEGETEAEGNVEHQGETEAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDGEGEAEANAEDQCETAQGEKGADGGGGSDGGDSEEEEDEEDEEEEEEEEEEEEEEESEEPLSLEWPESRQKQAIYLFLLPIVFPLWLTIPDVRRQEARKFFVITFLGSIIWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINALQPIPVSSNGLFCAIVLLFLMLLFVIFSIASCKWRMNKILGFTMFLLYFVFLVISVMLEDRIISCPVSV
Protein: Salvador family WW domain containing protein 1 (H0YJH0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
RNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQCQCCYCI
Protein: Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2) (O75343)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MSGYDRMLRTLGGNLMEFIENLDALHSYLALSYQEMNAPSFRVERGADGKMFLHYYSDRSGLCHIVPGIIEAVAKDFFDIDVIMDILDMNEEVERTGKKEHVVFLIVQKAHRKMRKTKPKRLQDSQGMERDQEALQAAFLKMKEKYLNVSACPVKKSHWDVVRSIVMFGKGHLMNTFEPIYPERLWIEEKTFCNAFPFHIVFDESLQVKQARVNIQKYVPGLQTQNIQLDEYFSIIHPQVTFNIFSIRRFINSQFVLKTRREMMPVAWQSRTTLKLQGQMIWMESMWCMVYLCSPKLRSLQELEELNMHLSDIAPNDTTRDLILLNQQRLAEIELSNQLERKKEELQVLSKHLAIEKKKTETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNICTACEPIQIVNVLNSMYSKFDRLTSVHAVYKVETIGDAYMVVGGVPVPIGNHAQRVANFALGMRISAKEVTNPVTGEPIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAYRALKNQGFKIIERGEIEVKGKGRMTTYFLIQNLNATEDEIMGRSKTPVDHKGSTQKASLPTTKLQGSVQPSCPEHSSLASWLL
Protein: Sideroflexin-5 (Q925N0)
Organism: Mus musculus (Mouse)
Function: Mitochondrial amino-acid transporter (By similarity). Transports citrate (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity). In brown adipose tissue, plays a role in the regulation of UCP1-dependent thermogenesis probably by supporting mitochondrial glycerol-3-phosphate utilization.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:36334589}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MADTATTASAASAAASAPNASTDAPPFQLGKPRFQQTSFYGRFRHFLDIIDPRTLFVTEKRLREAVQLLEDYKHGTLRPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLVQRFVPFPAVASANICNVVLMRYGELEEGIDVLDADGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVHSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIARATSSRTVVYNKGL
Protein: Iron regulatory protein-1A (O76934)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361275}.
Interaction partners:
Sequence:
MSGSGANPFAQFQESFTQDGNVYKYFDLPSIDSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWTPSLKQETSDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQVNFVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSSADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPXDRVSVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSVMLGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPLGVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEISTYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRDFNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDVFDAAERYASEGTPLVLVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVYNIVLPEGELKPGQRIQVDADGNVFETTLRFDTEVDITYYKNGGILNYMIRKMLD
Protein: Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1) (Q8N126)
Organism: Homo sapiens (Human)
Function: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:38074074}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:38074074}.
Interaction partners:
- Nectin-1
- Cell adhesion molecule 1
- Nectin-3
- Protein PALS2
- Cell adhesion molecule 4
- MAGUK p55 subfamily member 3
- Disks large homolog 3
Sequence:
MGAPAASLLLLLLLFACCWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVTSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKDTATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSVPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSYKAYYTLNVNDPSPVPSSSSTYHAIIGGIVAFIVFLLLIMLIFLGHYLIRHKGTYLTHEAKGSDDAPDADTAIINAEGGQSGGDDKKEYFI
Protein: dual-specificity kinase (EC 2.7.12.1) (B1AVT0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR