wanglab/gogpt-training-data huggingface dataset:
Protein: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC 4.1.2.21) (2-oxo-3-deoxygalactonate 6-phosphate aldolase) (6-phospho-2-dehydro-3-deoxygalactonate aldolase) (6-phospho-2-keto-3-deoxygalactonate aldolase) (KDPGal aldolase) (Q6BF16)
Organism: Escherichia coli (strain K12)
Function: Involved in the degradation of galactose via the DeLey-Doudoroff pathway. Catalyzes the reversible, stereospecific retro-aldol cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with re-facial selectivity. It can use a limited number of aldehyde substrates, including D-glyceraldehyde-3-phosphate (natural substrate), D-glyceraldehyde, glycolaldehyde, 2-pyridinecarboxaldehyde, D-ribose, D-erythrose and D-threose. It efficiently catalyzes aldol addition only using pyruvate as the nucleophilic component and accepts both stereochemical configurations at C2 of the electrophile.
Interaction partners:
- 2-dehydro-3-deoxygalactonokinase
- D-galactonate dehydratase
- Galactonate operon transcriptional repressor
- D-galactonate transporter
- D-tagatose-1,6-bisphosphate aldolase subunit KbaY
- D-tagatose-1,6-bisphosphate aldolase subunit GatY
- D-tagatose-1,6-bisphosphate aldolase subunit GatZ
- D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
- KHG/KDPG aldolase
Sequence:
MQWQTKLPLIAILRGITPDEALAHVGAVIDAGFDAVEIPLNSPQWEQSIPAIVDAYGDKALIGAGTVLKPEQVDALARMGCQLIVTPNIHSEVIRRAVGYGMTVCPGCATATEAFTALEAGAQALKIFPSSAFGPQYIKALKAVLPSDIAVFAVGGVTPENLAQWIDAGCAGAGLGSDLYRAGQSVERTAQQAAAFVKAYREAVQ
Protein: Latent-transforming growth factor beta-binding protein 2 (LTBP-2) (Q28019)
Organism: Bos taurus (Bovine)
Function: May play an integral structural role in elastic-fiber architectural organization and/or assembly.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:8524260}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-2 proprotein
Sequence:
MRPPTTARCPGRVLQNPWRSFWPLTLALFVGMGQAQRDPVGRYEPAGRDASRLRRPGGSPVVATAKVYSLFREQDAPVRGSPPAELVQPSWGSPRRSTEAEARRPPRAQQPRRVQPPAQTWRSRPSGQQQSAPRARAAPALPRLETVQRPRAARGRLTGRNVCGGQCCPGWTTANSTNHCIKPVCQPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPEEEFDPQNSRPAPRRSAEGPPSLRRSSVARESTTARVRPPAPQLQRARTLSGLSQTRSSQQHVGLSQTTRLYPAPAASGQLTSNALPMGPGPERRDGAPQAAYLDRPSSSWGLNLTEKIKKIKIVFTPTICKQTCARGRCANSCERGDTTTLYSQSGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPANSTGKFCHLPAPRLDQEPPERGPRHRAPLEGPLKQSTFTLPLSNQLASVNPSLVNVHIRHPPEASVQIHQVARVRGEAEEAPEENSVETRPSPRLPAGPGPGRWDSNRIPARSGEAPRLPPPVVPRTPALLGRCYLSTLNGQCANPLPELTAHEDCCGSVGAFWGVTSCAPCPPRPASPVIENGQLECPQGYKRLNLTHCEDVNECLTLGLCEDSECVNTRGSYLCTCRPGLLLDPSRSRCVSDKAVSMQQGLCYRLLGPGTCALPLAQRITKQICCCSRVGKAWGSLCEKCPLPGTEAFREICPAGHGYTYSSSDIRLSMRKAEEEELARPSRDRGPKRNGTLPRPAERQPLRAATGTWVEAETIPDKGDSQASQVTTSVTQLSTWVPGGALGTPTPSVPEQGIPEAREEAQVTAPTNVLVTPAPSGIDRCAAGATNICGPGTCVNLPDGYRCICSPGYRLHPSQAYCTDDNECLRDPCKGRGRCVNRVGSYSCFCYPGYKLATSGATQECQDIDECEQPGVCSRGRCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGKCVNSPGSYTCLPCEEGYRGQGGSCVDVNECLTPGVCTHGTCINLEGSFRCSCEQGYEVTPDEKGCKDVDECAIRASCPTGLCLNTEGSFTCSACESGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCRDCEAGYQPSALGHTCEDVDECEDPQSSCLGGECKNTAGSYQCLCPPGFQLANGTVCEDVDECVGEEYCAPRGECLNSHGSFFCLCADGFVSADGGTSCQDVDECAVTDRCVGGQCVNTDGSFNCVCETGFQPSPESGECVDIDECEDLGEPICGAWRCENSPGSYRCVLGCQPGFHMAPTGDCIDIDECANDTVCGSHGFCDNTDGAFRCLCDQGFETSPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGRCRPRGAGGPSVPEARPGAHPPGPVRMECYSGQKDQTPCSSLLGRNTTQAECCCTQGTGWGDACDLCPDEDSVEFSEICPSGKGYIPVEGAWMFGQTTYTDADECVMFGPGLCRNGRCLNTVPGYICLCNPGYHYNAASRKCEDHDECQDMACENGECVNTEGSFHCFCSPPLTLDLSQQRCVNSTSGVEDLPDHDIHMDICWKRVTNYVCSHPLHGRRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGIHFRPGYEYSPGPDDLHYSLYGPDGVPFYNYLGPEDAIPEPLFPSTAGRPGDRIPLPEPPLQPSELQPHYVASHPGLCCCKNGEEVGSEAVSLPSSPSAHHCQQEHQAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDTAHMACVDVNECDDLNGPAALCVHGHCDNTEGSYRCHCLPGYVAEAGPPHCTAKE
Protein: Type 2 glycosyltransferase (EC 2.4.1.-) (G4MWY1)
Organism: Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Magnaporthe oryzae)
Function: Glycosyltransferase that plays an important role in infection-related morphogenesis and pathogenesis. Involved in stress tolerance and hyphal hydrophobicity via its regulation of the expression of nydrophobin MPG1. May regulate growth, pathogenicity, and cell wall integrity (CWI) through glycosylation of heat shock protein SSB1, and other (unidentified) substrates may contribute to conidiation. Candidate proteins as potential substrates of GT2 include several heat shock proteins (SSB1/MGG_02503, MGG_06759 and MGG_06958), two coiled-coil domain-containing proteins (MGG_04321 and MGG_09571), aminopeptidase 2 (MGG_16472), and a nuclease domain-containing protein (MGG_12646).
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MATPLQIMPLPVWPITFLEDAVVYLSALFTPWFTAFCVLWLHRYVRLIVHCYSHWTYKSKPIPSKPSYTSDDVTVVIPTIHDNFDELRPSLESILATKPHELIMVTTADKFEDLQRVAKTLSSPNIRIFCTQYANKRIQVCEALPKITTRITIMADDDVTWPSTMMPWILAPFEDPKIGGVGTCQRVKRVREGGLGLRIWNWLGAAYIERRNFEISATHNMDGGTSCMSGRTGAYRSEILRDYEFLEGFMKEEWWGKILKADDDNFVSRWLVSHKWKTWIQYEQECELETTLEDNIKFLYQCSRWARSNWRSNWTSLVKERHVWKQQWWCTYALHIATFTSLAFVFDFLILAALWWGTEGWEPVNRNRAIYAQLAFLAFSKVVKLVGLFRRHPADIMFLPVSIIFGYFHGLIKIYAGLTLNMTSWGSRTDGDTDDAHRLAPGPVRCSSLNTPRSEHKLPHYMQERDEIVNEKQQMREEEWEHL
Protein: RELA proto-oncogene, NF-kB subunit (A0A8I6ATQ5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
LSDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLTPVLSHPIFDNRKWPAAVRGEGGLGKRMGLGWVWPCCRGQEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPPRRIAVPSRGPTSVPKPAPQPYAFSTSLSTINFDEFSPMVLPPGQISNQALALAPSSAPVLAQTMVPSSAMVPSLAQPPAPVPVLAPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNNTDPGVFTDLASVDNSEFQQLLNQGVAMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPATLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS
Protein: Cell division cycle associated 2 (E9PEI0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSSVSGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ
Protein: Putative transcription factor bHLH107 (Basic helix-loop-helix protein 107) (AtbHLH107) (bHLH 107) (Transcription factor EN 55) (bHLH transcription factor bHLH107) (Q9LET0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Probable transcription factor PosF21
- Potassium transporter
- Leucine-rich repeat protein kinase family protein
- Transcription factor bHLH87
- DUF241 domain protein, putative
- At5g38890
- Protein PLANT CADMIUM RESISTANCE 11
- Protein PLANT CADMIUM RESISTANCE 9
- Protein PLANT CADMIUM RESISTANCE 4
- Protein PLANT CADMIUM RESISTANCE 5
Sequence:
MQPEVSDQIFYAFLTGGLCASSTSTTVTSSSDPFATVYEDKALASLRNHKEAERKRRARINSHLNKLRKLLSCNSKTDKSTLLAKVVQRVKELKQQTLEITDETIPSETDEISVLNIEDCSRGDDRRIIFKVSFCCEDRPELLKDLMETLKSLQMETLFADMTTVGGRTRNVLVVAADKEHHGVQSVNFLQNALKSLLERSSKSVMVGHGGGGGEERLKRRRALDHIIMV
Protein: Trehalose 6-P synthase (B3FTL1)
Organism: Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus)
Interaction partners:
Sequence:
MTTMPNNDVPNSPTSTSFSGTFSPAATAANTAANARSRDAPSPTTSSGPKLETNKDQRLIVVSNRLPVTISKDDNGEYHFKMSSGGLVSALSGCKKTMSFTWIGWPGKDIPMQDRETVNRRLLEEYNCYPVYLSDELADSHYNGKFSNSILWPLFHYHPGEMNFDAAHWLAYREANMRFADVVSSLVQAGDMVWVQDYHLMLLPMLLRSMITGESAQGEMVRQELGRVKEGVDDTVVKEVLKMDPGVAQAEDEGVEMLGDVEEEGGEMDVKSSPSKRPPYARGMSTFQKQEMVAKEKGKEGIRIGFFLHTPFPSSEIYRILPVRREILLGVLQCDLIGFHTYDYARHFLSSCTRILGLETQPNGIEFDGRYCQVGTYPIGIDPNQFVEGLQKESIVKRLRSLEARFEGVKVIIGVDRLDYIKGIPQKLQALETFLTQHPEWIGKVVLVQLAIPSRQDVEEYQDLRACVNELVGRINGRFGTVESVPIHYMHKSVPFEELTAMYALADACLVTSTRDGMNLVAYEYISSQAEKHGSMILSEFAGAAQSFNGSLLINPWDVQSTADAIYQALTLSPQQRKSNWQKLFNYVSKYTAEAWGVSFVNELNRLSGQRPSGPAGLAGRRKSGSLSRRSSKASIQRRKSSQSGGIVTGLGAAAGAAVNWAQSQVQGGSQA
Protein: cAMP receptor-like protein, putative (AFU_orthologue AFUA_5G04135) (Q5ATW8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Uncharacterized protein
Sequence:
MSLSAGQLFAISATERTCSTVSLFATSIIIVSFVSSQSFRKPINRLVFYASFGNIMANVATLISQSGIWAGTDSNLCQIQAFLIQWFMPADALWTFAMAFNVYLTFFRKYNSDQLRRLEWKYVMLCYGLPFIPAFTYFFIRTESRGKVYGSAILWCWVAPSWDFLRIAVFYGPVWFVIFVTLAIYARIGELVWRRRRQLKEVGGLDTTLDVSIPDDPPFSKVTEIRIEREDAASYRPEAGPSTEQDPPFSCAQSIPRPYSVNVQAGSSQLELGAIRSEEPFDGPPTREYRSSSTALEVNTAAWAYTKYAMLFFVALLVTWVPSTINRVYAFIRPDASNFGLNYASSFVLPLQGFWNSLIYISISWRCFKPALSDLHNRLLWYTHLGAGHRRPSSGQDSTRRLTN
Protein: Thioredoxin reductase 1, cytoplasmic (EC 1.11.1.2) (EC 1.8.1.9) (Peroxidase TXNRD1) (Thioredoxin reductase TR1) (A0A182DWI3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPAMLPTGSHSAVLPPSHCSTAPPSTSQEPSSSADPKLCLSPPTSDSRQERNVQFGLAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
Protein: Transcription factor bHLH14 (Basic helix-loop-helix protein 14) (AtbHLH14) (bHLH 14) (Transcription factor EN 33) (bHLH transcription factor bHLH014) (O23090)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Bidirectional sugar transporter SWEET15
- B3 domain-containing protein At3g06220
- Stomatal closure-related actin-binding protein 2
Sequence:
MYNLTFSPSLSSSLLSFTQQTPAAIVSSSPPDLVLQQKLRFVVETSPDRWAYVIFWQKMFDDQSDRSYLVWVDGHFCGNKNNNSQENYTTNSIECELMMDGGDDLELFYAASFYGEDRSPRKEVSDESLVWLTGPDELRFSNYERAKEAGFHGVHTLVSIPINNGIIELGSSESIIQNRNFINRVKSIFGSGKTTKHTNQTGSYPKPAVSDHSKSGNQQFGSERKRRRKLETTRVAAATKEKHHPAVLSHVEAEKQRREKLNHRFYALRAIVPKVSRMDKASLLSDAVSYIESLKSKIDDLETEIKKMKMTETDKLDNSSSNTSPSSVEYQVNQKPSKSNRGSDLEVQVKIVGEEAIIRVQTENVNHPTSALMSALMEMDCRVQHANASRLSQVMVQDVVVLVPEGLRSEDRLRTTLVRTLSL
Protein: Protein numb homolog (m-Nb) (m-Numb) (Q9QZS3)
Organism: Mus musculus (Mouse)
Function: Regulates clathrin-mediated receptor endocytosis (By similarity). Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P49757}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49757}; Cytoplasmic side {ECO:0000250|UniProtKB:P49757}. Endosome membrane {ECO:0000250|UniProtKB:P49757}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49757}; Cytoplasmic side {ECO:0000250|UniProtKB:P49757}. Note=Localizes to perinuclear endosomes in an AAK1-dependent manner. {ECO:0000250|UniProtKB:P49757}.
Interaction partners:
- E3 ubiquitin-protein ligase Mdm2
- Neurogenic locus notch homolog protein 1
- E3 ubiquitin-protein ligase Itchy
- Neurogenic locus notch homolog protein 2
- Dihydropyrimidinase-related protein 2
- Epidermal growth factor receptor substrate 15
- Neurogenic locus notch homolog protein 3
- Neurogenic locus notch homolog protein 4
- E3 ubiquitin-protein ligase LNX
- Numb-like protein
Sequence:
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVVGPSVAPGNTAPSPSSPTSPTPDGTASSEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNTVPEVEGEAESISSLCSQITSAFSTPSEDPFSSAPMTKPVTLVAPQSPVLQANGTDSASHVLTAKPANTALAHVAMPVRETNPWAHVPDAANKEIAAIHPGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQVSAAPLQPVLQPPPPAAIAPPAPPFQGHAFLTSQPVPVGVVPPLQPAFVPTQSYPVANGMPYPASNVPVVGITPSQMVANVFGTAGHPQTTHPHQSPSLAKQQTFPQYETSSATTSPFFKPPAQHLNGSAAFNGVDNGGLASGNRHAEVPPGTCPVDPFEAQWAALESKSKQRTNPSPTNPFSSDLQKTFEIEL
Protein: F-box and WD repeat domain containing 5 (GH09073p) (Q9VMI1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- DNA damage-binding protein 1
- Cullin-4A
- Protein transport protein SEC23
- Gigas, isoform A
- Protein salivary glands marred
- GEO01111p1
- RING-box protein 1A
- Cullin homolog 1
- DDB1- and CUL4-associated factor 12 homolog
Sequence:
MEVTFKKARLGKERLVEQSEEEERDEGSSGQDLFGWWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQEHFKASPSIPLKPGSESWRAEYKRLSMHIPFVQAQRLEPTVENNHGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQHPCSEKYAHNMKQFSWKYSQYSQFNQSDTLLLVSGVHFGSPQSTSGEIAVFYLGATESHLRCRVVNRPYDIFGTWFSDQYLISGDLHWLAHLVSTSVLWLNKANQEIDSEHVPIMSQLYKFYNRNASSVRAIMVARCPWLDESNDPLATTADQESHSSVLSPPTGDQGSTSQASGNPVSHAASILRTRSSTPEENYLPDISERRSRARLGDATIHYLDEYRTAVATTNESNDDDDEEYDSMDVQEEYDEMENSIPKYLIFSTGSTTFTPHQIGFKRIRNVFFPKKLDPGPSLKERIAAKRAAEQQQQQTPRTDPDWWDYESVKDRFDKVDKVIDLHGHIIGMALSPDHRYLYVNTRPWPKNYVITNPLEPPPIAQEIDIHVIDLMTLKRVGNMLRAHKAYTPSAECFFIFLDVCEEYVASGAEDQHAYLWDRYYGISLAKFKHSDVVNSVAFNPRDSEMLVTTSDDYTIKVWRSRAKAKEFNIPINVSESFELKPKN
Protein: Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) (P49813)
Organism: Mus musculus (Mouse)
Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P28289}. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments. {ECO:0000250|UniProtKB:P28289}.
Interaction partners:
- Alpha-adducin
- Beta-adducin
- Gamma-adducin
- Dematin
- Tropomyosin alpha-3 chain
- Tropomyosin beta chain
- Nebulin
- COP9 signalosome complex subunit 1
- COP9 signalosome complex subunit 3
- Band 4.1-like protein 2
Sequence:
MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPMDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALGSSSIVNKEGLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPELEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAFALAEMLKVNKVLKTLNVESNFISGAGILRLVEALPHNTSLVELKIDNQSQPLGNKVEMEIVNMLEKNTTLLKFGYHFTQQGPRLRASNAMMSNNDLVRKRRLADLTGPIIPKCRSGV
Protein: Gasdermin-like protein het-Q1 (Heterokaryon incompatibility protein Q1) [Cleaved into: Gasdermin-like protein het-Q1, N-terminal] (B2AXJ5)
Organism: Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Function: Gasdermin-like protein involved in heterokaryon incompatibility, a process that ensures that during spontaneous vegetative cell fusion, only compatible cells from the same colony survive (non-self-recognition). In P.anserina, the het-q locus exists as 2 incompatible alleles, het-Q1 (this entry) and het-Q2 (AC P0DW09). This form constitutes the precursor of the pore-forming protein: during the allorecognition process, it is cleaved by het-Q2, releasing the N-terminal moiety (Gasdermin-like protein het-Q1, N-terminal) that binds to membranes and forms pores, triggering cell death.
Subcellular location: [Gasdermin-like protein het-Q1, N-terminal]: Cell membrane {ECO:0000250|UniProtKB:P57764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P57764}.
Interaction partners:
Sequence:
MPTKTSQHAFAGSERWVVPRYSSKPGTLIRLGSVLTDPEDLESSLNLDSIPPIPPHLLRDATPEVRMSVQTELSKSDSTLAKAAPALEGILTLGGGVEASRSQGVSSSLNISGTVKATVFRADKSYMDVLLKDKNVISYAKRGLGKPMFVVVGVATAGRVEMKETRHVTRKAGVSGKVGVEVIGEGEVGLERERSDKSCNEVRGEGGLDFAYRVREFGYSRVRGTVKDKGDWTGKVLFAGGKGPVVEKGGEVVPVFKEFKEGEVKLRATGSFDVAAKA
Protein: RNA polymerase I-specific transcription initiation factor RRN9 homolog (Accumulation of condensin at rDNA protein 1) (Q10204)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and is required for the proper accumulation of rpa1/nuc1 at rDNAs. Required for nucleolar localization of condensin.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:18362178}.
Interaction partners:
- RNA polymerase I-specific transcription initiation factor rrn5
- RNA polymerase I-specific transcription initiation factor rrn11
- RNA polymerase I-specific transcription initiation factor rrn7
- TATA-box-binding protein
- Upstream activation factor subunit spp27
- RNA polymerase I-specific transcription initiation factor rrn10
- Uncharacterized protein C3B8.11
- RNA polymerase I-specific transcription initiation factor rrn3
Sequence:
MNDSEEELEQQGSQEDISSSQDTSDEKEMRKQDALYAQLIEYREIVSELRRSEMKNLCIQLYCSYKAGITRRNELQSDLDGYERRIPPRLRAVWPTIHSIPDESFFDGTSASRFRQEAAYLAVRLASKKLHKLGRMASSEELPNPDGLRYLVERLQIKLERLFDSVDTFRQEQGSKSMQSRVKPMDWKILYGLARVTNGSFSSSQKADVLALGNGTRACQSLFKEMSLQPSIDIEKVSHSNPEISIEFED
Protein: Appr-1-p processing enzyme family protein (Q8H114)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MRRQWLTSGLSSLPGLLHSSSTILRPTSSSSSRASLISFAVNNFHTIASSSSTLSSRLTTVSSSMASGDEGAVFNLSDSSLLKILKGDITKWSVDSSSDAIVNPANERMLGGGGADGAIHRAAGPQLRAACYEVPEVRPGVRCPTGEARITPGFNLPASRVIHTVGPIYDSDVNPQESLTNSYKNSLRVAKENNIKYIAFPAISCGIYGYPFDEAAAIGISTIKQFSTDFKEVHFVLFADDIFSVWVNKAKEVLQKA
Protein: Zinc finger protein 111 (A0A8I6G8Y2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGLLDAAQRKLYHDVMLENLRNLLAVGGQSPNKMKTVDATGIRCLLLGQLLYWEITGHDANKLARAPEAVVNTQGKGSHFLEQGHSSCHREAEEPPRASEDDSSLDSLTRDHSSTTENQEFLSGRAQGSWCKTHLRKRQNHQKHCLQTLMKNKPELLTQHSPVQRTQEDSRHSSSVPIQQSVHPGRKRYWCHECGKGFSQSSALQTHRRVHTGEKPCRDNSCRKSFSRSSGLSIHRQVHTGERPYRCKVCGKGFLRWSHLQAHERIHTGEKPYKCGECGKRFSCISNLHTHQRFHSKEKPYKCDKCGKCFSLNFNLHIHQRVHTGEKPYKCEECGKCFSLSFNLHSHQRVHTGEKPYKCEECGKCFSSASSFQRHRQIHIKEKTLHRDVCGKGSSRDSNLQTHQRVHIQEKPYRCNSCGKSFRCSMDLNIHRRVHTGEKPYKCEVCGKGFNYLSHLQAHEKIHADQKPYKCEYCGRRFSYSSNLHTHQRVHTGEKPYKCEECGKSFSLASSLQAHQRVQTGKKPFKCNACQKRFSQAWNLQAHQRVHTGEKPYKCDTCGKAFGQRSSLQIHQRIHTGEKPFKCEECGKEFSLNSGLTAHRRVHTGEKPYECTECGKGFSLASSLRTHQRIHTGEKPFQCNECQKRFSQVSHLQSHQRVHTGEKPYKCDTCGKAFSQKSGLQVHRRIHTGEKPFKCEECGKEFIWSSGLSAHRRVHTGEKTLHG
Protein: Glutathione S-transferase F3 (AtGSTF3) (EC 2.5.1.18) (GST class-phi member 3) (Glutathione S-transferase 16) (Q9SLM6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde. May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Interaction partners:
- Methionine--tRNA ligase, cytoplasmic
- Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic
- Glutathione S-transferase L1
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase U25
- Glutathione S-transferase DHAR2
- Glutathione S-transferase U23
- NADH dehydrogenase 1 beta subcomplex subunit 10-A
- Glutathione reductase, chloroplastic
- NADH dehydrogenase 1 beta subcomplex subunit 2
Sequence:
MAGIKVFGHPASTSTRRVLIALHEKNLDFELVHVELKDGEHKKEPFLSRNPFGQVPAFEDGDLKLFESRAITQYIAHRYENQGTNLLPADSKNIAQYAIMSIGIQVEAHQFDPVASKLAWEQVFKFNYGLNTDQAVVAEEEAKLAKVLDVYEARLKEFKYLAGETFTLTDLHHIPVIQYLLGTPTKKLFTERPRVNEWVAEITKRPASEKVL
Protein: Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2) (Q9Z2E1)
Organism: Mus musculus (Mouse)
Function: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well (By similarity). Recruits histone deacetylases and DNA methyltransferases to chromatin (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Acts as transcriptional repressor and plays a role in gene silencing (By similarity). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (By similarity). May enhance the activation of some unmethylated cAMP-responsive promoters (By similarity). Selectively represses transcription activity of methylated rRNA promoters.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9UBB5}. Chromosome {ECO:0000250|UniProtKB:Q9UBB5}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase. Localizes to methylated chromatin. Localizes to sites of DNA damage in a manner partially dependent on ZMYND8. {ECO:0000250|UniProtKB:Q9UBB5}.
Interaction partners:
- Histone deacetylase 1
- Histone-binding protein RBBP7
- Histone deacetylase 2
- Transcriptional repressor p66-beta
- Histone-binding protein RBBP4
- Chromodomain-helicase-DNA-binding protein 4
- DNA helicase
- Transcriptional repressor p66 alpha
- Metastasis-associated protein MTA2
- Metastasis-associated protein MTA1
Sequence:
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAARGGGVCGRGRGRGRGRGRGRGRGRGRGRPQSGGSGLGGDGGGGAGGCGGGSGGGVAPRRDPVPFPSGSSGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNAVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKFTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEVDIDMDSGDEA
Protein: Large ribosomal subunit protein uL14 (60S ribosomal protein L23) (P62832)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62829}.
Interaction partners:
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL24
- Mitochondrial ribosomal protein S9
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL3
Sequence:
MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA
Protein: Actin cross-linking protein (DUF569) (At1g59710/T30E16_31) (F23H11.2 protein) (Q9XIF7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEIFQKAKAVRLRSHHDKYLVADEDEESVTQERNGSAGAAKWTVEIIPGSTNLIRLKSAYGKYLTASNKPFLLGATGKKVLQTKPSRLDSSLAWEPIRDSALVKLKTRYGNFLRGNGGLPPWRNSVTHDIPHRSATQEWVLWHIDVVEILPANANSDHHHQHLQLQQPPSPLHHSDSLDFTPGSPSRSDRFFRQESTDSLAVGSPPKSEGRVIYYHVADDDDDVEDDSVEVSSFTFKGNGVEELTMRLKEESNVEDVIVCTRSPLNGKLFPLRLQLPPNNADMTVVLVPKSSKIAEKFIK