wanglab/gogpt-training-data huggingface dataset:
Protein: Ubiquilin 2 (D4AA63)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Desumoylating isopeptidase 1
- RCG31562, isoform CRA_c.
- Ubiquitin-ribosomal protein eL40 fusion protein
- Polyubiquitin-C
- RNA-binding protein FUS
- Transitional endoplasmic reticulum ATPase
- Optineurin
- Ubiquitin conjugation factor E4
- Proteasome
- Next to BRCA1 gene 1 protein
Sequence:
MAENGESSGPPRPSRGPAAAPGAANPPAEPKIIKVTVKTPKEKEEFAVPENSTVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQATTQPSTTAGTSTTTTTTTTAAAPPAATTSSAPRCSTTATTTNSSNLGLGSLASLGNLGLNSSNFTELQNQMQQQLLASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPMLNAAQEQFGGNPFATVGSSSSSGEGTQPSRTENRDPLPNPWAPPPTTQTSATTTTTTTSSGTVAGSNTSSTTAGNTMAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDMAAQMMLSSPLFTANPQLQEQMRPQLPNFLQQMQSPETIAAMSNPRAMQALLQIQQGLQTLATEAPGLIPGFTPGVGVGVLGTAITPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPASSPGSTGTGIPPATTVSSSAPTETISPTSESGPSQQFIQQMVQALTGGSPPQPPNPEVRFQQQLEQLNAMGFLNREANLQALIATGGDINAAIERLLGSQPS
Protein: Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (O60879)
Organism: Homo sapiens (Human)
Function: Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
Subcellular location: [Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.
Interaction partners:
- Rho-related GTP-binding protein RhoD
- Profilin-1
- Transforming protein RhoA
- Profilin-4
- Profilin-3
- Protein diaphanous homolog 1
- Protein POF1B
- Cell division control protein 42 homolog
- Bone morphogenetic protein 15
- WD repeat and HMG-box DNA-binding protein 1
Sequence:
MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITTAAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPDNRRVPLERSRSRHNGAISSK
Protein: Killer cell lectin-like receptor subfamily A, member 1 (Ly-49L) (O75889)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MNDQGEIYSTLRFLQSPSESQNRLRPDDTQRPGKTDDKEFSVPWHLIAVTLGILCLLLLMIVTVLVTNIFQCIQEKHQRQEILRNCSEKYIMQNDNYLKEQILTNKTLKYDVLKNSFQQKKELDSRLIQKNRCHRENEIVFKVLQNTGKFSEDHGSCCGVNCYYFTMQKKDWKGCKQTCQHCRSSLLKIDDKDELVFYIHFYSLGLCFSMLDLRY
Protein: Hexose transporter HXT10 (P43581)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable glucose transporter.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Carbon catabolite-derepressing protein kinase
Sequence:
MVSSSVSILGTSAKASTSLSRKDEIKLTPETREASLDIPYKPIIAYWTVMGLCLMIAFGGFIFGWDTGTISGFINQTDFKRRFGELQRDGSFQLSDVRTGLIVGIFNIGCALGGLTLGRLGDIYGRKIGLMCVILVYVVGIVIQIASSDKWYQYFIGRIVSGMGVGGVAVLSPTLISEISPKHLRGTCVSFYQLMITLGIFLGYCTNYGTKKYSNSIQWRVPLGLCFAWAIFMVIGMVMVPESPRYLVEKGKYEEARRSLAKSNKVTVTDPGVVFEFDTIVANMELERAVGNASWHELFSNKGAILPRVIMGIVIQSLQQLTGCNYFFYYGTTIFNAVGMQDSFETSIVLGAVNFASTFVALYIVDKFGRRKCLLWGSASMAICFVIFATVGVTRLWPQGKDQPSSQSAGNVMIVFTCFFIFSFAITWAPIAYVIVAETYPLRVKNRAMAIAVGANWMWGFLIGFFTPFITRSIGFSYGYVFMGCLIFSYFYVFFFVCETKGLTLEEVNEMYEERIKPWKSGGWIPSSRRTPQPTSSTPLVIVDSK
Protein: Multidrug resistance protein MdtF (P37637)
Organism: Escherichia coli (strain K12)
Function: Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}.
Interaction partners:
- Multidrug resistance protein MdtE
- Outer membrane protein TolC
- Multidrug efflux pump subunit AcrA
- Cation efflux system protein CusC
- Multidrug resistance outer membrane protein MdtP
- Multidrug resistance protein MdtA
- Multidrug export protein AcrE
- Glutamate/gamma-aminobutyrate antiporter
- Macrolide export ATP-binding/permease protein MacB
- Glutamate decarboxylase alpha
Sequence:
MANYFIDRPVFAWVLAIIMMLAGGLAIMNLPVAQYPQIAPPTITVSATYPGADAQTVEDSVTQVIEQNMNGLDGLMYMSSTSDAAGNASITLTFETGTSPDIAQVQVQNKLQLAMPSLPEAVQQQGISVDKSSSNILMVAAFISDNGSLNQYDIADYVASNIKDPLSRTAGVGSVQLFGSEYAMRIWLDPQKLNKYNLVPSDVISQIKVQNNQISGGQLGGMPQAADQQLNASIIVQTRLQTPEEFGKILLKVQQDGSQVLLRDVARVELGAEDYSTVARYNGKPAAGIAIKLAAGANALDTSRAVKEELNRLSAYFPASLKTVYPYDTTPFIEISIQEVFKTLVEAIILVFLVMYLFLQNFRATIIPTIAVPVVILGTFAILSAVGFTINTLTMFGMVLAIGLLVDDAIVVVENVERVIAEDKLPPKEATHKSMGQIQRALVGIAVVLSAVFMPMAFMSGATGEIYRQFSITLISSMLLSVFVAMSLTPALCATILKAAPEGGHKPNALFARFNTLFEKSTQHYTDSTRSLLRCTGRYMVVYLLICAGMAVLFLRTPTSFLPEEDQGVFMTTAQLPSGATMVNTTKVLQQVTDYYLTKEKDNVQSVFTVGGFGFSGQGQNNGLAFISLKPWSERVGEENSVTAIIQRAMIALSSINKAVVFPFNLPAVAELGTASGFDMELLDNGNLGHEKLTQARNELLSLAAQSPNQVTGVRPNGLEDTPMFKVNVNAAKAEAMGVALSDINQTISTAFGSSYVNDFLNQGRVKKVYVQAGTPFRMLPDNINQWYVRNASGTMAPLSAYSSTEWTYGSPRLERYNGIPSMEILGEAAAGKSTGDAMKFMADLVAKLPAGVGYSWTGLSYQEALSSNQAPALYAISLVVVFLALAALYESWSIPFSVMLVVPLGVVGALLATDLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAVEMMQKEGKTPIEAIIEAARMRLRPILMTSLAFILGVLPLVISHGAGSGAQNAVGTGVMGGMFAATVLAIYFVPVFFVVVEHLFARFKKA
Protein: Interleukin 5 receptor subunit alpha (G3V6S7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Interleukin-5
- Colony stimulating factor 2 receptor subunit beta
- Interleukin-3
- Interleukin-4
- Granulocyte-macrophage colony-stimulating factor
- Tyrosine-protein kinase JAK2
- Thymic stromal lymphopoietin
- Interleukin-13
- Tyrosine-protein kinase
- Granulocyte colony-stimulating factor
Sequence:
MTNSLIYCWRVAASFPYKRQHSELGRLSSTFPTTMVPVLLILMGASATLHADLLSPEKFLLLPPVNFTIKATGLAQVLLHWDPNPDQAPVDLEYHVKINVPQEDEYDTKNTESKCVTPLHEGFAASVRTILKSIHSPLASSWVSAELKAPPGSSGTSVMNLTCTTNTVKSSHTHFRPYQVSLRCTWLVGKDAPEDTQYFLYYRFSVWTEECQEYSKDALNRNIACWFPRTFINSKGFEQLAVHINGSSKHAAIKPLDQLFTLYAIDQVNPPMNVTVEIENNSLYIQWGKPLSAFPVHCFKYKLKIYNTKNGYSQMENLVTNKFISKIDDVSTYSIQVRAAVSSPCRMSGSWGEWSQPIYVGKKKKPLVEWHLIVLPTAICFILLIFSLICRVYHLWTRLFPPVPAPKSSIKDLPVVTEYEKPPWNETKIEIVHFVEEDGFEVMENSMF
Protein: Small ribosomal subunit protein eS10 (40S ribosomal protein S10) (P63326)
Organism: Rattus norvegicus (Rat)
Function: Component of the 40S ribosomal subunit.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P46783}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P46783}. Note=Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus. {ECO:0000250|UniProtKB:P46783}.
Interaction partners:
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein eS26
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein eS1
Sequence:
MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGPEGERPARFTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ
Protein: Phosphatidylinositol 3-kinase (Q54S78)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Phosphatidylinositol 3-kinase 2
- Phosphatidylinositol 3-kinase 3
- Phosphatidylinositol 3-kinase 1
- Phosphatidylinositol 3-kinase
- Inositol 5-phosphatase 4
- LIM-domain containing phosphatase
- PIPK domain-containing protein
- phosphoinositide 5-phosphatase
- Phosphatase and tensin homolog
- Probable phosphatidylinositol phosphate kinase DDB_G0267588
Sequence:
MNDNNNNYTNNEEIINQLKSKNQETETKILKLYNAVKIDKIKRKQEFENIEEQNRKLSIQIIDLNNKIEVTNNSNEKEIELLRNQIQKEKDKFENGLIKSKEFEKSYNSSSPLNNSQSFRQLKEFEINCHHLETKLNDSSIINSSKTNHLNQLITSTESKIENHNKILQEKERIKNNKIEYELLLEELDKINKSVNLTNSGPNSMYITILDNEIMNNLVISLENNIKTLKSPNSSTTSFISSNGGSSNGGSSIISSNGSSDSSLSFENLSKLLIKQSSFDSNNLHKKKETNELQQQQQQQQQQQQQQQQQQQQQQQIETTATTTTVLLTAEEEFNKKIESIQIKQKERKMKIKESLSNSNNNLPIFAFENSIRYPINIITPTITYQLSYSLEFDTIQSLSNKIYQHIDSIDAVILKRLRIYSMEQLILKTSSNYYFQAVSQNQQPLKYIPYFSNINKNQSIDLYIVSKFVEDEFNTQMSTILGNDLLLENNRSTEESISFRNKMIKFLDQVKSHQIQLDNETTLLQSSSSTTTTTPTITTPPNILGNNISPFSSPPTSPNSSMSSLPSLKSSTSQLSLIIGNSRPLSQSCNSLNNLQDNNNNNNNNNNNSITNSKSSSSNNLFKSILKSNAINIAMNNNNSSNNNNEEFEQFIGNSWKSCSPSSSSLNKRLLMFSPSTSPMSSLSSSPMSSSPSTSMISLPNFMILKQKSINNLNLSSNWSLTESNCTIRLYITKNIIKTFVCSIQSTIGELKELIFKKFQKIIESEHHEIQSNKFLIKIRGLEIYLTNQQSQLSSIGYINSKSRRQKKIDLLLILINQFNMIEINKFQLDSYDFQFNQQLEKNIFFDQQLNENIFPSNLSYGCGKNFKIRIGSLKNFDISRIGKLYGIKNTSSSKIYVLAQIYQGEFYKISNEMQTPKLPLSSNPSWLCTLEGPSFNQIPSNAIISLKVLINDTIIGWINYHIWNYKNKLNTGFMNLKLWSNDKIFNPTYLHRNYFNKNKNQNQNNNNNFTNYNESNEDDFETLMLSFEIDLSLQSIYFSPEPLDNHQLQILEEKYFMSTMSTPDSNQNQLIINSILKKDVLTDLKKEEKELIWKNRNYCKNQMNNSISKLILSVPWNDSESVQEFYWLLMNCPQFENPIDSLELLSQSFLDRQVRNFAIQNLCKMNDDDITMYLPQLIQAIKHEPHHYSILSKFLIRRVLLNKQNMAHIFFWQIKAEILTLKNGINPNEINDNNNNIDNNGDNNNNNNNNNNNNNNNNYNNDNDNDNYITNNSEFNNNNNNSVIQYPQWLERYQLILEIFLRGCSDEKLLEIYKQYQMYSKIKQVALGVKNVPNNKRKDYLIQVLGGGGSNGGNGNNDLLNYQEDFKTPINPEFRGKRIDVNGCKVKESKTLPLFLSIENYDPMGDNSFVIFKAGDDLRQDQLVIQMINIMDKMWLDDGIDLQTITYRCIATGPMEGMIEVVGDSITIAEIQKQQGGITAAFSETVISQWLKQENPSELEYSNAVENFIRSCAGCCVYSYILGIGDRHNDNIMITKSGHLFHIDHGRFLGNVQTWNGIKRERAPFVFTNAFANVIGGENNFKNFEDLCSRAYNTIRKHANVILNLFLMMVGGGLPELSKKSDIYYLRDALALDLTNEQAAIKFSNMIQESLVSRSTDLNFAVHILANPN
Protein: Protein WUSCHEL (AtWUS) (Plant growth activator 6) (Q9SB92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expression of its own repressor, the AGAMOUS (AG) gene at the end of flower development. Binds directly to the 5'-TTAAT[GC][GC]-3' DNA sequence in the regulatory sequence of AG and activates its expression directly. Regulates one important step in ovule development to induce integument formation from the underlying chalazal domain. Participates in the promotion of vegetative to embryonic transition. Required to repress LEC1 expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:9865698}.
Interaction partners:
- Protein CLAVATA 3
- Receptor protein kinase CLAVATA1
- Receptor-like protein CLAVATA2
- Zinc finger protein KNUCKLES
- CLAVATA3/ESR
- B3 domain-containing transcription factor LEC2
- Somatic embryogenesis receptor kinase 1
- Two-component response regulator ARR7
- Protein LEAFY
- LRR receptor-like serine/threonine-protein kinase RPK2
Sequence:
MEPPQHQHHHHQADQESGNNNNNKSGSGGYTCRQTSTRWTPTTEQIKILKELYYNNAIRSPTADQIQKITARLRQFGKIEGKNVFYWFQNHKARERQKKRFNGTNMTTPSSSPNSVMMAANDHYHPLLHHHHGVPMQRPANSVNVKLNQDHHLYHHNKPYPSFNNGNLNHASSGTECGVVNASNGYMSSHVYGSMEQDCSMNYNNVGGGWANMDHHYSSAPYNFFDRAKPLFGLEGHQEEEECGGDAYLEHRRTLPLFPMHGEDHINGGSGAIWKYGQSEVRPCASLELRLN
Protein: NADH dehydrogenase (Ubiquinone) 51 kDa subunit-like 2, isoform A (EC 1.6.99.3) (A1Z9Z7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- Probable NADH dehydrogenase iron-sulfur protein 7
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- NADH dehydrogenase 23 kDa subunit
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase iron-sulfur protein 4
- NADH dehydrogenase 24 kDa subunit, isoform A
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- AT21479p
Sequence:
MLRQKLKNYLPSVWEQQLRLVQTAKKAGGSKKLGPDRPPIIDPPKGYEPNCKTKFGPLDDCDRVFQNLYGRHDWRLHGACQRGDWHRTAELLEQGPEWIMKQVSKSGLRGRGGAGFYAGLKWEFLRQTKSEKVPKMVIVNCAEGEPGTCKDRDILRHEPHKLIEGILLVGVAMGCGRAIVYIRNRFYNEACNLHFALAEAYHHGLLGNSVCGTGIKFDVMVQRGDRYLCGEETAMINCLMGKLGRPRRRPPFLTEKGYFEHPCLVINAESIAVVPTILRRGSQWWAGLGRSYNTGTKLYCLSGQVNNPCTVEEEMSIPLKDLIERHAGGVKGGWDNLAAVFPGGLSTPLLDPSTAGKVLMDFDSLTDAGSGFGCGAVIVMTKDCDPLAIMLRSIQFFEKHTCKQCSYCRDGAIWLPEIFARFVKGQTHPHEIDWTLVIADKMRNSKPICALAYSQVSVAESLVRMFSRKIEERLLKYAKGS
Protein: Ketol-acid reductoisomerase, mitochondrial (EC 1.1.1.86) (Acetohydroxy-acid reductoisomerase) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (G8B5K3)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Subcellular location: Mitochondrion {ECO:0000256|PIRNR:PIRNR000119}.
Interaction partners:
- dihydroxy-acid dehydratase
- Acetolactate synthase
- ACT domain-containing protein
- Branched-chain-amino-acid aminotransferase
Sequence:
MSFRTNSIRMAKLATSKATLSKRTFSLLANATRTSTIAKASMPMMAIRGVKTINFGGTEEVVHERADWPKEKLLDYFKNDTLALIGYGSQGYGQGLNLRDNGLNVILGVRKNGASWKAAVEDGWVPGENLFDVNEAVEKGTIIMNLLSDAAQSETWESIKPLLTEGKTLYFSHGFSPVFKDLTHVEPPKNIDVILAAPKGSGRTVRSLFKEGRGINSSYAVWNDVTGKAEEKAIAMAIAVGSGYVYQTTFEREVNSDLYGERGCLMGGIHGMFLAQYEVLRENGHTPSEAFNETVEEATQSLYPLIGKYGMDYMYDACSTTARRGALDWYPRFKDALKPVFEDLYESVRNGTETKRSLDFNSQPDYRERLEEELQTIRNMEIWKVGKEVRKLRPENQ
Protein: Flagellar transcriptional regulator FlhD (P0A2R2)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (Probable).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00725}.
Interaction partners:
- Flagellar transcriptional regulator FlhC
- Anti-FlhC
- Diguanylate cyclase/phosphodiesterase domain 2
- RNA polymerase sigma factor FliA
- Motility protein B
- Flagellin
- Flagellar hook-associated protein 2
- Flagellar protein FliL
- Negative regulator of flagellin synthesis
- Flagella basal body P-ring formation protein FlgA
Sequence:
MHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMANTLGALTLPQMVKLAETNQLVCHFRFDDHQTITRLTQDSRVDDLQQIHTGIMLSTRLLNEVDDTARKKRA
Protein: Cytosolic Fe-S cluster assembly factor NAR1 (Nuclear architecture-related protein 1) (P23503)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential component of a cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15103330}. Nucleus {ECO:0000269|PubMed:15103330}. Note=Predominantly cytoplasmic.
Interaction partners:
- MIP18 family protein YHR122W
- Cytosolic Fe-S cluster assembly factor CFD1
- Cytosolic Fe-S cluster assembly factor NBP35
- DNA repair/transcription protein MET18/MMS19
- Fe-S cluster assembly protein DRE2
- Adrenodoxin homolog, mitochondrial
- NADPH-dependent diflavin oxidoreductase 1
- Cytosolic iron-sulfur protein assembly protein 1
- Iron-sulfur clusters transporter ATM1, mitochondrial
- Cysteine desulfurase, mitochondrial
Sequence:
MSALLSESDLNDFISPALACVKPTQVSGGKKDNVNMNGEYEVSTEPDQLEKVSITLSDCLACSGCITSSEEILLSSQSHSVFLKNWGKLSQQQDKFLVVSVSPQCRLSLAQYYGLTLEAADLCLMNFFQKHFQCKYMVGTEMGRIISISKTVEKIIAHKKQKENTGADRKPLLSAVCPGFLIYTEKTKPQLVPMLLNVKSPQQITGSLIRATFESLAIARESFYHLSLMPCFDKKLEASRPESLDDGIDCVITPREIVTMLQELNLDFKSFLTEDTSLYGRLSPPGWDPRVHWASNLGGTCGGYAYQYVTAVQRLHPGSQMIVLEGRNSDIVEYRLLHDDRIIAAASELSGFRNIQNLVRKLTSGSGSERKRNITALRKRRTGPKANSREMAAATAATADPYHSDYIEVNACPGACMNGGGLLNGEQNSLKRKQLVQTLNKRHGEELAMVDPLTLGPKLEEAAARPLSLEYVFAPVKQAVEKDLVSVGSTW
Protein: Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (Nucleoporin Nup85) (Q6DK84)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Involved in nephrogenesis.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q9BW27}. Nucleus membrane {ECO:0000250|UniProtKB:Q9BW27}.
Interaction partners:
- Nucleoporin SEH1
- Nucleoporin Nup37
- Nucleoporin 43kDa
- Nucleoporin 133.
- Protein SEC13 homolog
- Mucolipin 2.
- Nuclear pore complex protein
- Nuclear pore complex protein Nup98-Nup96
- Nuclear pore complex protein Nup93
- Glucosaminyl
Sequence:
MEELDVDPAETPIPGLGQQNRHIGFSWGPGDLLLYETLYQKQGSETAARCPFMYLVRSDEDIYSPVLRKLFNESHSIFVGLQKSAEENAGKSRKAQLVQVSRNYRSVLRACMEEMHALSESTREPSQNTKYISQISILSAMELSWNLCEILFIESAPAGPLLILLLDWVRLHVCEVDNIVQDVLRSERPTEHEKFWDGVTGYVLQGRMNEARQLLAKEASSSVSARSMCRVLDDLLKKMPMLNTAGTQTLTEFELKWQHWREECERHLQNGTFSSNPHMEVVCRVLVGDEEVILEKRDLMTTWYHFLVSRLLFKHPTVKPTELHFYAQSSLDMFLAGNSSPEPLDNILLAAFEFDIHQVIKEFSIVSSNWWFVAHLTDLLDHCQLFQAHNLYFGANMREFLLLDYASGLFSHHSLWQLGVDYFDYCPNLGHVYLELHMERVPLNTEKKALKALRICEKRQMTEQVRSICKTMAMQSLCNGRLGSALSWSIRAKDAAFATLISDRFLKEYSERGNFTDLDLIDNLGSAMLLSDRLTFLGKYREFHRMYSQEQFSEAASLLLSLMTARIAPCSFWLTLLLDALPLLEQKQVIFSAEQTYELMRCLEDRMAAKLDSTSPDEIQKQDSVDSTKIEMLRLALARNLARAIVTEGALQE
Protein: Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) (Q7Z699)
Organism: Homo sapiens (Human)
Function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16115197}; Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Membrane, caveola {ECO:0000269|PubMed:16115197}; Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Nucleus {ECO:0000269|PubMed:16115197}. Note=Localized in cholesterol-rich membrane raft/caveola fractions.
Interaction partners:
- Neurofibromin
- Sprouty-related, EVH1 domain-containing protein 2
- GTPase NRas
- GTPase KRas
- Epidermal growth factor-like protein 7
- Phosphatidylinositol 3-kinase regulatory subunit beta
- GTPase HRas
- Mast/stem cell growth factor receptor Kit
- Ras GTPase-activating protein 1
- Fibroblast growth factor receptor-like 1
Sequence:
MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFIRGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFEDLNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDETKLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG
Protein: Protein CLASP-1 (Q95YF0)
Organism: Caenorhabditis elegans
Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (By similarity). Operates redundantly with cls-2 and cls-3 in regulating microtubule processes which position the spindle during asymmetric cell division.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Kinesin-like protein
- Calponin homology domain-containing protein
- Lipoprotein
- Lipoprotein
Sequence:
MDTNWLYVLLQKSTADPLERLKLGNVILNEVSQRKVSPHPKLVNDFLDVMSGWLTGSNFKVSTIGLEILDAALRTSPDVLASYYFDRCSVLIERMGDAKVQVREMAINLCLQLAYLENSSPVMLLDRLCVPGTGFQHKQWLVKVGSLNILREFLSSSFALVIQQAITLIPQLCRLTNDPNSEVRDVSTQCLIDLMVYGGKPIVAKIAATRLINEQKMATLLQRYQTTVATRGDLPPKHTITMETTPAQPSRNSLLRRSLRSPAKIIHPSASTTSFTSSARLSTPPRPTTTAAQSLSLAPQTPSPLSLPSPSGGQMSRSRDLTRSSLRAPAGISISRYRSSSCAPAAQCAITLDDFKKSFTAVPKTTIYSNHDIREKLELANLVLRNANEDWSKRANQLKLIRSIIINCDENIDRSLLISIINELADALEFSIRDLRSQIVREAAVTCSFLFETFGMEVKNVAECVLPAALAQVAVSTKVIASSAATLTVFIVQKIQTRQIFTTLSELSSSKAKEQRRQLAVVLETLIASWDLKSKQPILKQIAQLVQNAICDADGETRVAGRKAFAKLEQLHGTTADLIFRELDPAKQKMLRDGVSSSSSSLNSDRDNNNQKQQPNQQNISQKFLSQRSASAVDKSIQLSVKPQTTAIPSRPTAMPMNNRLPKSSTSTSFSAVRSSGYGQNQSTTPNRAKTPSDGFAGSSPHYTNGNNNNKSSSSSPSTSTHQTPIQRVASNLGSSSFVASLTQEQANCLQNAMNTAKDEMSKNNEDDEFLLDEIRKTPPKEVPRSYNNSPFKPSNLDSSVHRSYNNNSPFRPSSGSVGSGSNGSVQSIEHILKACTSSSLNEKRDAIVNLNQVITDPNLCQLECKNIGDTLSRLLAEGNNTLIISILDTISIFIKFQYKKLDNWLKLALGKLFAKMGADALPNVKSALSSTQKMFLTTFDPTFQLKAVCDFMCDPVHLLSPKSRLALLEYICLLFEEIWPEDPRCLERQTHLDTPYTRAAIRKMFAWMFDPRIGAILMPACERLVCALFALNAADFTMIFGELPSECRDWAYRILQLNGQQNNQKPIEKEKERFISNNNYKPCPLDNEEIEKPIMKTTYSTYESTRKEYSQTERIATENQYSTPPPPDYRTSTAHLAKNHVDQAAYIRNQLDAIRDFEKADKLNEAMANLHGMMCEGSFTLWNQFFDELLDSIYQILSTFSQSIRKKLALRILQKMCTAQATKLFDSTEIAISKVLQCACTSDDNTMGVAAEDCLRILASHLPLTRVVLISRRILSQDDDDQRGVLILKMLTRMFQDIDIEELHLIVNDVAPCFVTAYESMSSTVRKCAVFGLVALVQRVGMQRMEPHLRTLNASKLNLIDLYVGRAKSSESGASSN
Protein: Klf2b protein (Krueppel-like factor 2b) (Kruppel-like factor 2b) (Q90XE7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Krueppel-like factor 2a
Sequence:
MALPCLLPSISTFANQKEKLWEDRWKIEEHKPLNASCPPLNVALNTDTCRGRKDDEDLSNYLDLEFILANTTGPLEAGAEFISHSEPCGMYSTAVYSSPEAPPPYGLMAELLRSDVDSTYDTTVQGRFLLNSSGFPRQEFPEIKVEPPMDGYGPVIGMVPQTCQKIKQEGNVSCMMSFEQPRLAVSPQATGNMTPPLSPDDSHLRQTTYTQSYHHSPPAYPQVPMQFTAPHQFAMYEEAMGMQPSMQRALLTPPSSPLELMESKPKRGRRTWPRKRMATHTCTYAGCGKTYTKSSHLKAHHRTHTGEKPYHCNWEGCGWKFARSDELTRHFRKHTGHRPFQCHLCERAFSRSDHLALHMKRHL
Protein: Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)] (Q86L14)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54113}.
Interaction partners:
- Bifunctional purine biosynthetic protein purD
- Adenylosuccinate lyase
- Bifunctional purine synthesis protein purC/E
- Adenylosuccinate synthetase
- Phosphoribosylformylglycinamidine synthase
- Inosine-5'-monophosphate dehydrogenase
- formate--tetrahydrofolate ligase
- Amidophosphoribosyltransferase
- Phosphoribosylglycinamide formyltransferase
- Serine hydroxymethyltransferase 2
Sequence:
MQALLSVYNKSGIVEFSKILSSKGFNLISTGGTAKSLVDNGLKVQQVSDVTEYPEMLDGRVKTLHPKIHGGLLARPELAHHQADLNKYNIKPISIVVVNLYPFVETVSKESTTLEEAIENIDIGGHTLIRASSKNFQNVLIIVDPSDYKWIGERIQSSTDSTNVLSSITLEERKKLALKAFQHGCSYDAAVSQYLSKVELTNATTIQGVKGTDSASVNVEFPQTFLPLYEKKNDLRYGENPHQKAALYQCPGTGGIANAQLLHGPALSYNNILDGDAALKAVREFDRCACVVIKHTNPCGLSVGVNDSEQAEVYKRAFNGDPKSAYGGILGFNRTLTLETATALKSVFYEVIIAPDYTEDALALLSKKEKLRILRIPEAANQIQFTQPDIRTITGGALLQSPNPIIRGDLAEATKNWKVVTENKPTEQQMKDLLFAWRVSKHVKSNAIVLSKDETIVAIGAGQPNRSQSVDICMKVGGDKVKGSVLASDAFFPFADSIDLAHQGNIACIVQPGGSIRDQEVIDAANKYGIPMVFTGNRNFLH