wanglab/gogpt-training-data huggingface dataset:
Protein: DNA replication licensing factor Mcm3 (EC 3.6.4.12) (Minichromosome maintenance 3 protein) (DmMCM3) (Q9XYU1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as component of the Mcm2-7 complex (Mcm complex) (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P25205}. Chromosome {ECO:0000250|UniProtKB:P25205}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250|UniProtKB:P25205}.
Interaction partners:
- CDC45L
- Double parked, isoform A
- DNA replication complex GINS protein PSF3
- Probable DNA replication complex GINS protein PSF2
- Origin recognition complex subunit 2
- DNA replication licensing factor Mcm5
- DNA replication licensing factor MCM4
- DNA replication licensing factor Mcm2
- Cell division control protein
- DNA replication licensing factor Mcm6
Sequence:
MAHEGEQFIKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPRSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAYPTKDEDGNLLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGKRGGYTSGTFRTVLLANNISLLSKESNLDISREDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDAEDDNGEASSQRSPSRRSKRTRTATVGADSDEEDIEPPQPDAGDLTRRETRRSLPARSVAMLMASPSSEEQSVATSTTEPAIISDARLGEFKNNLQRLFREAREQSLALARITTAINVGSQEPFTAGEIEAAVHRMTEDNQIMVADDIVFLI
Protein: An-Nup2 Nuclear pore complex protein (Eurofung) (Q5B4D5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Nucleoporin NSP1
- mRNA export factor GLE1
Sequence:
MVVCTYFQQGRCKFGDRCKNEHPRSQQTFTGGNRFGALSAGGGFNSRGFSGQNQQSKQEPANYGITTADIKADLTAGEGRPIWVFSCYGPGKNAPRQLFGGPQREQSFEELRLRHYEAAAAGNPGPAIQEAENMYNEAVNQMEVVLRNLNAALKYVVDGANEHPNRIDIIKGDTGSGVGQTSAFGQSSTPAFQGSGFTQQAPSRPAFGQPSFGQPSLGQPSGFGQPSFGQPSGFGQPSALGASSGFGKPAFGQPSQPSFGKPSLGQSGFGQPSTLGGSGFGQASDTASPFSQISATPASGFGNASPFAQAGSGFANSSTAPATTGGFGVPSQPNNPFSQPSAPFGQPVQPTNPSPFGTTTQQPAAAPSSAFGQPAGGSIQISQPASSGPVGAGPPPFIRIENPNELAPIPPLSGPTTHNPMTKKLQTWKGQPVQYIDDVPCYLHPQDRKTYVRIFFPDGPPDAASLRDAQAEPDQYTPEVTEQYEFFIKNGYFKDGLIPRVPPKTEWVSFDF
Protein: Ferroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein) (Q9BRQ8)
Organism: Homo sapiens (Human)
Function: A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms. Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way.
Subcellular location: Lipid droplet {ECO:0000269|PubMed:31634900}. Cell membrane {ECO:0000269|PubMed:31634900}; Lipid-anchor {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:12135761, ECO:0000269|PubMed:26689472}. Mitochondrion membrane {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:26689472}. Nucleus {ECO:0000269|PubMed:26689472}.
Interaction partners:
- Cellular tumor antigen p53
- Phospholipid hydroperoxide glutathione peroxidase GPX4
- Large ribosomal subunit protein mL64
- Long-chain-fatty-acid--CoA ligase 4
Sequence:
MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVETGFAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLFVSTSWKTMRQSPP
Protein: Uncharacterized protein (Q21821)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein linkin
- Glycerophosphocholine cholinephosphodiesterase
Sequence:
MSDTPEQEQDFELIDGAERKSSTSDSFEAVDEKKNGSQSVSENEDDNADKSAKEEDDEVEEEMKLPFVDQSIKDDANRPKEKDGEDLVEEALKAPIRPDQEQFYTAEHSNRAITLLIAFSAMMFTLPLLVMASLYYWVFIDHFHLPPAEAMLYAGVCAALVVILIAAAFCYIAWKEEKDAEDKLRAEKKKE
Protein: Methyl-CpG-binding domain protein 3-like 1 (MBD3-like protein 1) (Q8WWY6)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor.
Subcellular location: Nucleus {ECO:0000269|PubMed:12504854}. Note=Nuclear, in large foci.
Interaction partners:
- Metastasis-associated protein MTA1
- Chromodomain-helicase-DNA-binding protein 3
- Histone deacetylase 2
- Histone-binding protein RBBP4
- Metastasis-associated protein MTA2
- Metastasis-associated protein MTA3
- Cyclin-dependent kinase 2-associated protein 1
- Histone-binding protein RBBP7
- Transcriptional repressor p66-alpha
- Transcriptional repressor p66-beta
Sequence:
MAKSSQRKQRDCVNQCKSKPGLSTSIPLRMSSYTFKRPVTRITPHPGNEVRYHQWEESLEKPQQVCWQRRLQGLQAYSSAGELSSTLDLANTLQKLVPSYTGGSLLEDLASGLEHSCPMPHLACSSDAVEIIPAEGVGISQLLCKQFLVTEEDIRKQEGKVKTVRERLAIALIADGLANEAEKVRDQEGRPEKR
Protein: SNF2 DNA repair protein, putative (Q383K6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RuvB-like helicase
- RuvB-like helicase
- Histone H2A
- HIT-type domain-containing protein
- Transmembrane protein, conserved
- YEATS domain-containing protein
- YEATS domain-containing protein
- Uncharacterized protein
- Actin-like protein, putative
Sequence:
MSSSRKRPRESGVGDLHITVEAQQADGIPPTACARHLSLLLQQRQQQRLRLAAAPLSFSYAPVTVLSPWQRVTLSSFQRLHGSEQDERHAVGLRRALQRDLGRYMEDTKRREERIRAEQREARARLGARLSTAVGKLWSRRGDIFQQLLAVEFDEVKQRRAEQRQEDLLREAENLTRTLLESIFSDVKCNDKDDGGRGGNISENVVALLEGGDETNISCGAQLETSLSLLDTQGGSRQLRDYQRSALRWMTNLYSRGLNGILADEMGLGKTIQTIALLAYYAEYKNDWGPHLIVVPTTVVLNWKAEFQRWCPGLQVIVYMGSKKERHRVRQGWMQEDAFNICITSYNQVVKDRVVFRRRPWGFLVLDEAHQVKNFMSKKWQSLFDLQVEYRLLLTGTPLQNSIMELWSLFHLLLPSASAFSSDQEFREWFSNPMEEMVTGRAALNEGIVRRLQALLRPFMLRRLKKDVEAQLPSKTEKVVMCRLSRRQRMLYDDYMQLAETRERISGGARGVLGVLLALRKVCNHPDMFEERRTVTPMALDHQSEIVIEVPRDVLLRGNNYSGCYRFQKWRLCIDDVSLPSQRGEPHDVARVEDGTLFDDSWLHCTKLYVLTVDHWWRMQEQEISRYIARYSTDNFHWPSDVPRIPPGNEGLSEDIMSVIQNYVEEEMMTTDQRRRMTTTIQVERYHRMSASVCVGYPNCLHIALPFQEQEDVRWGEGKCCALSHLPRGLRPTLRQRVNAVLPIAFKVAVYVPAAVAARPPRLHCRLPVAHYQSFRAHCRRSLAPLLAIALPPPASQFSRKTSNRANLFDASPFLYELWPLYVRRCFSFPDRHLLIHDCGKLQFLKHCLKQLRREGHRMLIFTQFVHMLNILERFLALIGLPYLRIDGSTQPERRQAYVDWFNEDERITCMILSTRSGGIGLNLTGADTVIFYDSDWNPTMDLQAQDRCHRIGQTKPVTIYRLISEHTVEESILQKARERKKLNNVVIRGGQFHAMANVDDVYEDTSAALAALSNPVQLRSFFHDLDEDATVVADDPLPGNGHQDNGGRCDIKEGSGTENNEAVDIRVEMMRLEDQEDREAQQNVEEELRKLEEQKRNDEEELGDEDKDEEDEDEDGHPQQRRGEGREEGEMMADPMVAVSLMSGRGSPAVLQKRRDILRRQRTPLDQLLSLQYAVCHNVEARRRYAGLCESYARQVGEDELPLFTETFNS
Protein: Cell death abnormality protein 2 (Cell-corpse engulfment protein CED-2) (Q9NHC3)
Organism: Caenorhabditis elegans
Function: Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration.
Interaction partners:
- CED-5
- Tyrosine-protein kinase abl-1
- Cell death abnormality protein 12
- E3 ubiquitin-protein ligase CBL
- Rap guanine nucleotide exchange factor 1
- Receptor tyrosine-protein kinase let-23
- Ras-related protein ced-10
- Cell death protein 6
- Stress-activated protein kinase JNK
- Cell death abnormality protein 1
Sequence:
MTTNGFDPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDSSRPGEYSLTVREADEGNAVCHYLIERGEPKEDGTAAAGVKIANQSFPDIPALLNHFKMRVLTEASLLAAYKKPIIEVVVGTFKFTGERETDLPFEQGERLEILSKTNQDWWEARNALGTTGLVPANYVQIQMEFHNDRTSKGASQSSIGSSGGGAERFSSASTSSDNIELQPRLPAKAKVTFDRVPNAYDPTQLRVKKGQTVLVTQKMSNGMYKAELDGQIGSVPHTYLRFTAVSE
Protein: Uncharacterized protein, isoform C (Uncharacterized protein, isoform D) (A1ZAP7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform C
- Enoyl-CoA hydratase domain-containing protein 3
Sequence:
MRELPYYPPSNEMIEANTNQDLSANNSVFGDFMKTKRLEFYNVCSVMQTLLTIDDLSNMELYAQLIQSDVPVQRVSKLTYKITFKSTPVNAEDFVAPNLDQVVLVPKASLLASPLPKQLVLALLPHPHEDLEPGDPMLRHVASVDKVSSTTVHVRFSRKHKAVLSGQRFYAIIRSRRLTIRYMYRALNLLQESPLVRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTIALKLCEYIESNIRLQEHFAQQKLPEPDHQLIRVYSRSIYEKGFASVPSLLLKNSNCSKSIYDHIKASRIVKYGIIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEPEALIGIMGIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLLQSDCYKSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDVNLAANWSVLTNPQFPIIFQATHGVTNREQNSTSSYNNLEAEVICWYVKRLINDRVVGQEDVGIVAPYTAQGKLVTKLLQSKGYPNVEVGSVETYQGREKTIIIASLVKSFTNMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKKHGTYLLKKRDSGQRPHILIKADESNEESSSEPEDEDDKLIPSYARMQQHTDAAIHKIKAHPTNENDQLANSFKISMSKLSI
Protein: Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) (Q3MIB4)
Organism: Rattus norvegicus (Rat)
Function: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
Subcellular location: Peroxisome matrix {ECO:0000250|UniProtKB:Q86WA8, ECO:0000255|HAMAP-Rule:MF_03121}.
Interaction partners:
- Peroxisomal leader peptide-processing protease
- Peroxisomal targeting signal 1 receptor
- ATP-dependent clpX-like chaperone, mitochondrial
- Mitochondrial disaggregase
- ATP-dependent Clp protease proteolytic subunit
- Peroxisomal membrane protein PEX14
- Peroxisome biogenesis factor 10
- Peroxisomal membrane protein PEX13
- 60 kDa heat shock protein, mitochondrial
- GrpE protein homolog 1, mitochondrial
Sequence:
MSSVNPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDSQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNTCKTREELGELSEQFYRYSVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHIPGALEDEEEEEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQLTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVAEGQHKEAKLDRSDVADGEGCKEHVLEDAKPESIGDAADLALPPEMPILIDSHALKDILGPPLYELEVSERLSQPGVAIGLAWTPLGGKIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYHLTNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKHIIIPQRNEKDLEEIPSNVKQDLSFVTASCLDEVLNAAFDGGFTVKTRPGLTDSKL
Protein: TBC1 domain family member 8B (Q0IIM8)
Organism: Homo sapiens (Human)
Function: Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:30661770}.
Interaction partners:
- Importin subunit alpha-6
- Mirror-image polydactyly gene 1 protein
- Biogenesis of lysosome-related organelles complex 1 subunit 6
Sequence:
MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKVAPFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIRGLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYLSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQTYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSLTSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVTNKDSPLPSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGNIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKLSLQELDELYVIFKKELFLSCYWCLGCPVLKHHDPSLPYLEQYQIDCQQFRALYHLLSPWAHSANKDSLALWTFRLLDENSDCLINFKEFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTEVKSKDASKGDELSKEELLYFSQLHVSKPANEKEAESAKHSPEKGKGKIDIQAYLSQWQDELFKKEENIKDLPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAVVTSLLLRMEEVGRKLHSPTSSAKGFSGTVCGSGGPSEEKTGSHLEKDPCSFREEPQWSFAFEQILASLLNEPALVRFFEKPIDVKAKLENARISQLRSRTKM
Protein: Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (Complexed with DOR1 protein 4) (Component of oligomeric Golgi complex 5) (P53951)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9UP83}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UP83}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 7
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 2
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 4
- ADP-ribosylation factor-like protein 1
- Protein SYS1
- Protein transport protein GOT1
Sequence:
MTIAPMANDLEDFESLLEPDFDAKQFGNDLLKATNNNDTTILDLNTPLKKLNYDLHEIDSRIDQLMNSNPLEIIELIYKNEHVNSTIVGELKPSLGYMNMSYDRLKNQVLDPYERARKVQLALSKVYQTSFLLRGALLYIHLSNKLNALSKTAQLSTSTAINLASLHYQLEITLEENKNLKSLRKIKQLDQDIVSPNKRELITFLSLQMCKECLNSIKIKSNKEIISQLAYSLYLLSSQEFESAINKIVLSNVTMSSQILSKILNSIRMFPDAFNEVVEKGYNIYILETLLQNIKTDNVTNSSRSIAANKSRLGNLLSEYTSMKSKAGSGTPRDLFWSKVSSAFKKDFDISVNRGGPVGKSLLKNKDFIINTMKQSMKKSSDNSDYQSYLDVMLNSVSISLNK
Protein: TRAF family member associated NFKB activator (E7EV32)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKQTENYEQRIREQQEQLSLQQTIIDKLKSQLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGIAREKLPKVRRQEVSSPRKETSARSLGSPLLHERGN
Protein: Cytosine-specific methyltransferase (EC 2.1.1.37) (Q72B90)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Very short patch repair endonuclease
- Cytosine-specific methyltransferase
- Cytosine-specific methyltransferase
- S-adenosylmethionine synthase
- Adenosylhomocysteinase
- DNA primase
- ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein
- Pseudouridine synthase
Sequence:
MKQHTPKHTPAKAVDLFCGAGGFSLAARNLGIEVVAALENNHYAAATYRHNFIEGSRRPPLLFEGDILAISPEAFMQAANLTPGGVDIIMGGPPCQGFSTHRIKGAGIDDPRNTLLLRYFEYVQAIRPRYFLVENVPGLLWPRHEEYLQRFYKLATEAGYHVSPPQVLNARDYGVPQNRKRVFILGTAGGHTLPDWPPRPTHFAPESSQVRAEGLPAWCTAAQVFATELANDDPNAIHLNHRPEMVEVFRSTPLNGGSRQQSCRVLPCHRNHNGHKDVYGRINPDAPGPTMTTACTNPSKGRFLHPTQHHGITVRHAARFQTFPETFTFKGGIMAASAQVGNAVPIDLGMAVIRPLLSALPACIARQSQ
Protein: Spermatogenesis-associated protein 6 (Kinesin-related protein) (Q3U6K5)
Organism: Mus musculus (Mouse)
Function: Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits.
Subcellular location: Secreted {ECO:0000305}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25605924}. Note=Specifically localizes to the segmented columns and the capitulum of the sperm connecting piece. {ECO:0000269|PubMed:25605924}.
Interaction partners:
- SUN domain-containing protein 5
- Outer dense fiber protein 1
- Polyamine-modulated factor 1-binding protein 1
- Ornithine decarboxylase antizyme 3
Sequence:
MPKVKALQCALALEIRSVTCPGVVLKDKEDIYLSICVFGQYKKTQCVPATFPLVFNARMVFEKVFPEAVDPGDVVAQLEYDTAVFELIQLVPPVGETLSTYDENTRDFMFPGPNQMSGHHDSNRQVTMRRISGLRGIAPKLEFSTTSVITECLISSRKCRTQDKFTYHSAPVEKSHGRLQCRTSRSQKKKSKSPERSKYCINTKNYEQPTISSKSHSPSPYTKRRMCELSEDTRRRLAHLNLGPYEFKKETDKPPFVIRHVDPPSPRTDNFFGSPGRDCERDGWVRMHSDHPHIGCCRSKDYKVIRSPHGRDFEDPFERCEEYLSPRTCSKPQHSARTLLVHSAPSTTPKHCASPVLNRASLRERFHSDWCSPPNCDEIHDRVKDVLKSHQAHARHLCDERDPEREDELELKRSLLYRDSAYDSDPEYSSFQRPRGSFHLDDGECWSNRAASCKGKSHRPVFENSMDKMYRNLYKKACSSVSHTQESF
Protein: Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) (O75976)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q90240}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Prestin
- Trans-Golgi network integral membrane protein 2
- Cation-independent mannose-6-phosphate receptor
- AP-1 complex subunit mu-1
Sequence:
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
Protein: Testis-specific Y-encoded protein 10 (P0CW01)
Organism: Homo sapiens (Human)
Function: May be involved in sperm differentiation and proliferation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q01534}. Nucleus {ECO:0000250|UniProtKB:Q01534}.
Interaction partners:
Sequence:
MRPEGSLTYRVPERLRQGFCGVGRAAQALVCASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGPMTPESALEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVEEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAEILCKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS
Protein: Endoplasmic reticulum-Golgi intermediate compartment protein (Q9HC06)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457, ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004457, ECO:0000256|RuleBase:RU369013}. Golgi apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU369013}.
Interaction partners:
Sequence:
MKEEEGFPEDEATESEKTLSLVKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITVAMKCQYVGADVLDLAETMVASADGLVYEPTVFDLSPQQKEWQRMLQLIQSRLQEEHSLQDVIFKSAFKSTSTALPPREDDSSQSPNACRIHGHLYVNKVAGNFHITVGKAIPHPRGHAHLGSTCSTMESYNFSHRIDHLSFGELVPAIINPLDGTEKIAIDHNQMFQYFITVVPTKLHTYKISADTHQFSVTERERIINHAAGSHGVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGIVGGIFSTTGMLHGIGKFIVEIICCRFRLGSYKPVNSVPFEDGHTDNHLPLLENNTH
Protein: Cytoplasmic tRNA 2-thiolation protein 2 (Cytosolic thiouridylase subunit 2) (Q2VPK5)
Organism: Homo sapiens (Human)
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Subcellular location: Cytoplasm.
Interaction partners:
- Cytoplasmic tRNA 2-thiolation protein 1
- Ubiquitin-related modifier 1
- Adenylyltransferase and sulfurtransferase MOCS3
- Neuronal calcium sensor 1
- Deoxyhypusine hydroxylase
- Elongator complex protein 3
Sequence:
MCQVGEDYGEPAPEEPPPAPRPSREQKCVKCKEAQPVVVIRAGDAFCRDCFKAFYVHKFRAMLGKNRLIFPGEKVLLAWSGGPSSSSMVWQVLEGLSQDSAKRLRFVAGVIFVDEGAACGQSLEERSKTLAEVKPILQATGFPWHVVALEEVFSLPPSVLWCSAQELVGSEGAYKAAVDSFLQQQHVLGAGGGPGPTQGEEQPPQPPLDPQNLARPPAPAQTEALSQLFCSVRTLTAKEELLQTLRTHLILHMARAHGYSKVMTGDSCTRLAIKLMTNLALGRGAFLAWDTGFSDERHGDVVVVRPMRDHTLKEVAFYNRLFSVPSVFTPAVDTKAPEKASIHRLMEAFILRLQTQFPSTVSTVYRTSEKLVKGPRDGPAAGDSGPRCLLCMCALDVDAADSATAFGAQTSSRLSQMQSPIPLTETRTPPGPCCSPGVGWAQRCGQGACRREDPQACIEEQLCYSCRVNMKDLPSLDPLPPYILAEAQLRTQRAWGLQEIRDCLIEDSDDEAGQS
Protein: TWIK-related acid-sensitive K[+] channel 6, isoform D (TWIK-related acid-sensitive K[+] channel 6, isoform E) (A0A0B4KFZ5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKKQNVRTISLIVCTFTYLLVGAAVFDALESETEKRRWEALQDAEDMIIRKYNISQEDFKVMETVVLKSESHKAGQQWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLVMFQSIGERVNRLSSYVIKAVRSSLRCKRTVASEVDLICVVTTLSSLTIAGGAAAFSKFEGWSYFDSVYYCFITLTTIGFGDMVALQRDNALNRKPEYVMFALIFILFGLAIVAASLNLLVLRFVTMNTEDERRDEAQAMQALQVAVKLEGDVITSNGSILSGYEGHDGQSLNGSNTSSMCSCHCICLNGNRHKKNQYKLRQSPTHIRHLLPEVVPMQDLNYDYDTQSLHTLADRGTMDSSYMGVDMADMGDTGSMELRPHTLLKRNVSLLSIRI