wanglab/gogpt-training-data huggingface dataset:
Protein: Muscarinic acetylcholine receptor M5 (Q920H4)
Organism: Mus musculus (Mouse)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Interaction partners:
- Metabotropic glutamate receptor 5
- Muscarinic acetylcholine receptor M1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Kininogen-1
- Muscarinic acetylcholine receptor M3
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein G
- HMW kininogen-II
Sequence:
MEGESYHNETTVNGTPVNHQALERHGLWEVITIAAVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEVKKRKPAHRTLLRSFFSCPRPSLAQRVRNQASWSSSRRSTSTTGKPTQATDLSADWEKAEQVTNCSSCPSSEDEAKATTDPVFQVVCKNEAKESPGKEFNTQETKETFVSPRTENNDYDTPKYFLSPGAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGLDPHLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
Protein: Carnitine O-palmitoyltransferase 1, muscle isoform (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (Carnitine palmitoyltransferase 1B) (Q8AYL4)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004374}.
Interaction partners:
Sequence:
MAEAHQAVGFQFTVTPDGIDLHLSRENGILTGVYPASPSSLLIVVITIMSTIYARIDPSLGMIDTIKRTMSVSGYMTVQTQTVLSAILFSTGLWLSLILMLRYILKALLSYHAWIFESHGKISFCTKLWLSLVKMLSGRRPLLYSFQTSLPRLPVPSVDDTITRYLESVRPLLDDEQYNQMEVVANDFKKDQAPKLQKYLILKSWWATNYVSDWWEEYFYLRGRSPIMVNSNFYSMDLLYVTPTHRQAARAGNVVHAMLQYRRKLERGEHAPLRALGVVPMCSYQMERMFNTTRIPGIETDFVQHLSDRKHLVVYHKGCFFKVWLYYGGRHLWPSELETQFQRILDDTTKPQPGELKLAAHTAGKRVPWARARLKYFSQGVNKASLEAIETSAFFLSLDDEAHGYDPDKLRSLDLYAKSLLHGKCYDRWFDKSFTLIAYKNGKLGVNAEHSWADAPIIGHMWEYVLATDCFLLGYTEEGHCKGDINKGLPLPTKLQWDIPLECQEVIEESYMVAKVIADDVDFHGCLFDEFGKGLIKKSRTSPDAFIQLALQLAQFRDKGEFCLTYEASMTRMFREGRTETVRSCTSESTAFVRAMEDKNTASAQKLDLFRKAADKHQNMYRLAMTGSGIDRHLFCLYIMSKYLSIHSPFLKQVLSEPWRLSTSQTPQQQLNMVDIKKFPRYVGAGGGFGPVADDGYGVSYIIIGENLITFHISSKFSSPETDSYRFGQNIRQAMLDIRALFDQKDKKEM
Protein: Small ribosomal subunit protein eS4B (40S ribosomal protein S4-B) (RP5) (S7) (YS6) (P0CX36)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
Sequence:
MARGPKKHLKRLAAPHHWLLDKLSGCYAPRPSAGPHKLRESLPLIVFLRNRLKYALNGREVKAILMQRHVKVDGKVRTDTTYPAGFMDVITLDATNENFRLVYDVKGRFAVHRITDEEASYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPDPNIKVNDTVKIDLASGKITDFIKFDAGKLVYVTGGRNLGRIGTIVHKERHDGGFDLVHIKDSLDNTFVTRLNNVFVIGEQGKPYISLPKGKGIKLSIAEERDRRRAQQGL
Protein: Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) (Q07647)
Organism: Rattus norvegicus (Rat)
Function: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P11169}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P11169}. Perikaryon {ECO:0000269|PubMed:24995978}. Cell projection {ECO:0000269|PubMed:24995978}. Note=Localized to densely spaced patches along neuronal processes. {ECO:0000269|PubMed:24995978}.
Interaction partners:
- Hexokinase-1
- Hexokinase-2
- Insulin-1
- Insulin-2
- Monocarboxylate transporter 4
- L-lactate dehydrogenase A chain
- Hexokinase-3
- Excitatory amino acid transporter 1
- Neutral amino acid transporter B
Sequence:
MGTAKVTPSLVFAVTVATIGSFQFGYNTGVINAPETIIKDFLNYTLEERLEDLPREGLLTTLWSLCVAIFSVGGMIGSFSVGLFVNRFGRRNSMLLVNLIAILGGCLMGFAKIAESVEMLILGRLIIGIFCGLCTGFVPMYIGEVSPTALRGAFGTLNQLGIVVGILVAQVFGLDFILGSEELWPGLLGLTIIPAILQSAALPFCPESPRFLLINRKEEDQATEILQRLWGTPDVIQEIQEMKDESIRMSQEKQVTVLELFKSPSYFQPLLISVVLQLSQQFSGINAVFYYSTGIFQDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAVCSVFMTISLLLKDEYEAMSFVCIVAILVYVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGMFFPSAAAYLGAYVFIIFAAFLVFFLIFTSFKVPETKGRTFEDITRAFEGQAHSGKGSAGVELNSMQPVKETPGNA
Protein: Cadherin 8 (J3KRI5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRWGLPIQWWEERNPIQTCLFSRSRIPRSLLFIFFHKDTKINCITQWTT
Protein: LD29352p (Q8T048)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEHHPSNQQILRLYTHVANATYQANEVARRFEKMLKRNPFQYTLWSNLIMITQGDMACCNVSAVLRIYEYSMRRMHVGHNDEITRRFIIKETDVIMLKLFHNCLLFLRQSGHTNWMFALIRLSMELNFPYLTFECLQAHAGREKALIGFEEVVLRSGMPMPEIWTRVEQLRQAYCFLPLKDKLASSTNVFKNKMNAERYFCSDKLVPYVHALKSQNNRLHLVLVVVQLMKLPLIRSASLADKLNPCIEDFGESEAIEMLFAAIVDRHSYAVASLQYQFDAAMIDLAREMSVTPSYMPHLVGHKLYADTVSNMLLKCVEVFIGEESKRRLLLILYLRFQKLLIVLHKSMGKLTKKFFKDKRTRMRKLINLTENRNVISFYTEQALCEIEAKHYRLGFSIISRIITKKSEESSCISCVDTMHLYLVCAELHIHRGRISKAIGILVSLCLEKHAGVKQTTVYSKEQVLKGLRNAEKMVRAELKSLDTQPAEMSLEEYFQPNKLLILLRAICLIEVLNNRRHKEARMWLNDLQNNEFGPEAVKDSERKRFLREQIMEIQMLHLRLSFLVFGEVEFYTGFKKIKLHELLENGLEEFPRNMVFLQLWASLKSIMWHKQRSRLIRTKAGIASLAHLVVAIHNRFGIVDTNDKFSKEATRKMVCNRLVSIVETFLPTNLDRLDVEEEHYRILRRNSIYWRLYMIALSKTNASFRRSKEVLIMAMDECPWDKSLLMEGAKVLPVKLASLQDLMTEKEIRIFAMPEEVDVLRGF
Protein: Jonah 25Bi (EC 3.4.21.-) (Q9VMX7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Jonah 25Bii, isoform A
- trypsin
- Jonah 25Biii
- Venom allergen-1
- LP12095p
- Serine protease 3
- Peptidase S1 domain-containing protein
- Jonah 44E, isoform A
- trypsin
- Jonah 99Fii
Sequence:
MKVFVVLALALAAVSAETVQQVHPKDLPKDTKINGRIVNGYPAYEGKAPYTVGLGFSGNGGWWCGGSIIAHDWVLTAAHCTNGASQVTIYYGATWRTNAQFTHTVGSGDFIQNHNWPNQNGNDIALIRTPHVDFWHMVNKVELPSFNDRYNMYDNYWAVACGWGLTTAGSQPDWMECVDLQIISNSECSRTYGTQPDGILCVSTSGGKSTCSGDSGGPLVLHDGGRLVGVTSWVSGNGCTAGLPSGFTRVTNQLDWIRDNSGVAYY
Protein: Inhibitor of growth protein 2 (Inhibitor of growth 1-like protein) (p33ING2) (Q9ESK4)
Organism: Mus musculus (Mouse)
Function: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm (By similarity). {ECO:0000250}.
Interaction partners:
- Paired amphipathic helix protein Sin3a
- Histone deacetylase complex subunit SAP30
- Histone H3.3
- Histone deacetylase 1
- Histone H3.1
- Histone H3.2
- Sin3 histone deacetylase corepressor complex component SDS3
- Breast cancer metastasis-suppressor 1-like protein
- Histone deacetylase complex subunit SAP30L
- SIN3-HDAC complex-associated factor
Sequence:
MLGQQQQQQLYSSAALLTGERSRLLSCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDSNQKKRLQQHLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSRRPRRQRTSESRDLCHMTNGIDDCDDQPPKEKRSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKERRAR
Protein: Yuri gagarin, isoform N (Yuri gagarin, isoform P) (Q2PDT6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEESPNDTLTADAITSDMLENLSIHDTQESEMLRLLNAELNDLLDLHNKQEFQTIEIRRKRVSCFIEKLVSEREDTLKKLESIRSHLTILQSDLDQSCLISVDPESGPCDLDADAQMLEALRRRLLNLSQLNRELHGKYQRLDTESKKLEARIESESSVLQRNSDVLREIAELICSLGSKEFSYNEIYDESSKENPFCTTIADMFARKFEQEQNQVEINGQLSCQIKGLQENLKDRDNQISQLQSMINSYSDFSENNRLKEEMHVLKQKNCDLSRQLRDLPSLLKNQENQSVELCTKYESLMASFEDQCQELKDAKRKAQSLQTRLDQVEQLQDELRTERKILREEVVALKEKEAVSSGRERALQDQQKSAQLEMEKMRTLVRKMQSHLQLDDIRHRESIQRMNETTESLREELRTISENCQQMQIRLNQQTEVNQQQEQIIDSFRKWKDAQVRADEAMRLCAKRAEEHIHMLLDENRTLAEDYRNLFRDYKLLETEIKRVKQAVNCASSSAISCPPPKSGGLTNPEAGNDMARRLQNLTSTSQRIFNQNQTMNDQYCNSLISGSPAGIGQPVAQSILRRTRSSQDQS
Protein: Sodium/potassium/calcium exchanger 5 (Na(+)/K(+)/Ca(2+)-exchange protein 5) (Solute carrier family 24 member 5) (Q71RS6)
Organism: Homo sapiens (Human)
Function: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18166528}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in late-stage melanosomes. {ECO:0000269|PubMed:17081065}.
Interaction partners:
- Membrane-associated transporter protein
- P protein
- Tyrosinase
- Two pore channel protein 2
- Tumor necrosis factor receptor superfamily member EDAR
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
- Melanocyte-stimulating hormone receptor
- Tumor necrosis factor receptor superfamily member 27
- Leucine-rich melanocyte differentiation-associated protein
- Agouti-signaling protein
Sequence:
MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG
Protein: Small ribosomal subunit protein eS17 (40S ribosomal protein S17) (P17704)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD31543p
- Ribosomal protein S30, isoform A
- Large ribosomal subunit protein uL16
- 40S ribosomal protein S15
- Large ribosomal subunit protein eL30
- IP17351p
- Small ribosomal subunit protein eS19A
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein eL32
Sequence:
MGRVRTKTVKKAAKVIIEKYYTRLTLDFHTNKRICEEVAIIPTKPLRNKIAGYVTHLMGRLRHSQVRGISIKLQEEERERRDNYVPAVSALEQDIIEVDADTKEMLKLLDFHNIRGLQLTQPNTNNFGRRN
Protein: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (K7EJU9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYSASLDPRAMGQCTAGRRGGRAAWWETGTPPPRTTVSAKSAAPPGDPARLLSVWKDTLAARAGPGEGGLSSPADKGRPDRAQE
Protein: superoxide dismutase (EC 1.15.1.1) (B2LYR9)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MECGSKATLKAVALITGDTNVRGFIHFTQIPNGITHVQGKITGLSPGLHGFHIHALGDTTNGCNSTGPHFNPLKKDHGAPSDGERHAGDLGNIIAGPDGVAEVSIKDWQIPLSGQHSILGRAVVVHADPDDLGKGGHELSETTGNAGARVGCGITGLQSSV
Protein: Branchpoint-bridging protein (G5EF97)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367126}.
Interaction partners:
- Splicing factor U2AF 65 kDa subunit
- Splicing factor 3A subunit 2
- Pre-RNA processing 21
- RNA helicase
- Cell division cycle 5-like protein
- Matrin-type domain-containing protein
- Uncharacterized protein.
- Splicing factor U2AF 35 kDa subunit
- WW domain-containing protein ZK1098.1
- DEAD-box ATP-dependent RNA helicase rde-12
Sequence:
MSKTGGNTEPMPFIRKWGNEAGEDLGAAPSATAAPPPALVVPTISSMSSGDNKSPSRSESVSDRKRDRSRSRDRDRKKDRKKKDRSRERDRERRSSRSRSRSPRDRDRERRRRRSRSPPPRRRSRSGGDRRRRERSPPSMVPNSPQRVKEPVINPLIREDLAAAVESGAVPVEAVQAGAVVALNPAKKERRSRWSTTKSFVPGMPTILPADLTEDQRNAYLLQLEIEDATRKLRLADFGVAEGRERSPSPEPVYDANGKRLNTREVRKRQELEQLRHEKIQALLKINPNFKPPADYRAPNIRLHDKVWIPQEQFPDLNFVGLLIGPRGNTLKSLEAETGAKIIIRGKGSIKEGKLTNRLGPMPGENEPLHAYVTGTDMNVIKKACEKIKQVIAEATALPDNNELRKLQLRELALLNGTFRPEDLANGARCSNCGSDEHKSWECPDAPNVTNQIKCTNCGAFGHISKDCKNPKGMYASEAGMDDEYSALMAELGETPAAGAGAGGGGGGHVASAGGGISAMTGAGGEAPGGGAGGRGGGAHGGAGRGGGYQGGRGGGRGFQNPRDLFGPPKGEEEQQQQANASMQHGYYDHYQQYAYPNQYQQPYGAPAPPGGSAYGHQQQQQQQQQQDYSDFYTSPGARGGAGAKANKGWYGSGGGSSMPMPVPPPGGLGGFMPPPPPPPPMPGDLSSLLAAAPPPPPS
Protein: Small ribosomal subunit protein uS17 (40S ribosomal protein S11) (Q0E9B6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Large ribosomal subunit protein eL38
- FI01658p
- Large ribosomal subunit protein uL29
- GM03767p
- Large ribosomal subunit protein eL39
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL2
- rRNA biogenesis protein RRP5
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL24
Sequence:
MADQNERAFQKQFGVNLNRKVKPGITKKKLLRRSRDVGLGFKTPREAIDGTYIDKKCPWTGDVRIRGRILTGVVRKAKMQRTIVIRRDYLHFVRKYSRFEKRHRNMSVHCSPVFRDVEHGDIVTIGECRPLSKTVRFNVLKVSKGQGAKKSFKKY
Protein: Probable thiol methyltransferase 1 (EC 2.1.1.9) (Protein HARMLESS TO OZONE LAYER 2) (AtHOL2) (O80562)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: S-adenosyl-L-methionine-dependent methyltransferase. Involved in glucosinolate metabolism and defense against phytopathogens (By similarity).
Interaction partners:
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- RING-type E3 ubiquitin transferase
- ATP-dependent protease La
- Phosphorylase superfamily protein
- At4g24340
- At5g01015
- Fanconi anemia group F protein
- ARM repeat superfamily protein
- Small ribosomal subunit protein mL103
- Pentatricopeptide repeat-containing protein At2g18520
Sequence:
MAEEQQNSSYSIGGNILPTPEEAATFQPQVVAEGGWDKCWEDGVTPWDQGRATPLILHLLDSSALPLGRTLVPGCGGGHDVVAMASPERFVVGLDISDKALNKANETYGSSPKAEYFSFVKEDVFTWRPNELFDLIFDYVFFCAIEPEMRPAWGKSMHELLKPDGELITLMYPMTDHEGGAPYKVALSSYEDVLVPVGFKAVSVEENPDSIPTRKGKEKLARWKKIN
Protein: Thioredoxin-like protein CITRX, chloroplastic (EC 1.8.-.-) (Cf-9-interacting thioredoxin) (AtCiTrx) (PEP-associated protein 10) (Thioredoxin Trx p) (Thioredoxin Z) (Q9M7X9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiol-disulfide oxidoreductase that plays a role in proper chloroplast development, most likely through regulating plastid-encoded polymerase (PEP) dependent chloroplast transcription. Acts as a component of the transcriptionally active plastid chromosome that is required for plastid gene expression.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:20133584, ECO:0000269|PubMed:20511297}.
Interaction partners:
- Fructokinase-like 1, chloroplastic
- Fructokinase-like 2, chloroplastic
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 10
- Plastid transcriptionally active 3
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 14
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 12, chloroplastic
- Thioredoxin F1, chloroplastic
- Pentatricopeptide repeat-containing protein At1g74850, chloroplastic
- Thioredoxin-like fold domain-containing protein MRL7, chloroplastic
- PLASTID TRANSCRIPTIONALLY ACTIVE protein 6, chloroplastic
Sequence:
MALVQSRTFPHLNTPLSPILSSLHAPSSLFIRREIRPVAAPFSSSTAGNLPFSPLTRPRKLLCPPPRGKFVREDYLVKKLSAQELQELVKGDRKVPLIVDFYATWCGPCILMAQELEMLAVEYESNAIIVKVDTDDEYEFARDMQVRGLPTLFFISPDPSKDAIRTEGLIPLQMMHDIIDNEM
Protein: HMG box domain-containing protein (Q584J1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFRKTLLFLFEKDGPTSIRRAVMAKARPHIGSGSTSNATSSIGGGASTSFMRGDVLPRRNGFIGGEPRSIIDRISSPNGSGASSTSSRRSALPPSEREEGKASGDASDDNYKFLLSHIDSKIAALKRRVPAVLDQRKNAEGSQNRRIRDLFECIERPWLLLASIPPPQLPNKALDVFAKEFYTRQNGTSTSGWEEDAIFLSTCKRNWRVLTTLQRKPYEIAARRNEQTRKELKKKMSNGCSYFEKLCEQTKEWTAEMVRDEMRKAVSAKTRSSPVVSKSRASSVAKKPVARRQGANKTEPKAAASKKEDKIVEVLKFEPVAKKEPKGAAGRAARERPLKGQVKKTAKGKAPVVAKKGKTSPRPVAAKLKKVKKK
Protein: Protein DETOXIFICATION 54 (AtDTX54) (Multidrug and toxic compound extrusion protein 54) (MATE protein 54) (Protein NOVEL ION CARRIER 2) (Protein NIC2) (Q9LE20)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as a multidrug and toxin extrusion transporter in the export of IAA-conjugates from the cytoplasm into peroxisomes.
Subcellular location: Peroxisome membrane {ECO:0000269|Ref.6}; Multi-pass membrane protein {ECO:0000269|Ref.6}.
Interaction partners:
- Protein DETOXIFICATION 44, chloroplastic
- Protein DETOXIFICATION 46, chloroplastic
- ABC transporter G family member 5
- ABC transporter G family member 9
- Protein DETOXIFICATION 42
Sequence:
MEDKIQSDDFTSHKNPTLPQVIEELKELWAMVLPITAMNCLVYVRAVVSVLFLGRLGSLELAGGALSIGFTNITGYSVMVGLASGLEPVCSQAYGSKNWDLLTLSLHRMVVILLMASLPISLLWINLGPIMLFMGQNPEITATAAEYCLYALPDLLTNTLLQPLRVYLRSQRVTKPMMWCTLAAVAFHVPLNYWLVMVKHWGVPGVAIASVVTNLIMVVLLVGYVWVSGMLQKRVSGDGDGGSTTMVAVVAQSSSVMELVGGLGPLMRVAVPSCLGICLEWWWYEIVIVMGGYLENPKLAVAATGILIQTTSLMYTVPMALAGCVSARVGNELGAGRPYKARLAANVALACAFVVGALNVAWTVILKERWAGLFTGYEPLKVLVASVMPIVGLCELGNCPQTTGCGILRGTGRPAVGAHVNLGSFYFVGTPVAVGLAFWLKIGFSGLWFGLLSAQAACVVSILYAVLARTDWEGEAVKAMRLTSLEMRKVGQDEESSLLLLDDEKLGDVL
Protein: PE-PGRS family protein PE_PGRS11 (PE-PGRS phosphoglycerate mutase) (EC 5.4.2.12) (Q79FW5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Induces maturation and activation of human dendritic cells (DCs), via TLR2-dependent activation of ERK1/2, p38 MAPK, and NF-kappa-B signaling pathways, and enhances the ability of DCs to stimulate CD4(+) T cells. By activating DCs, could potentially contribute to the initiation of innate immune responses during tuberculosis infection and hence regulate the clinical course of tuberculosis. Involved in resistance to oxidative stress, via TLR2-dependent activation of the PI3K-ERK1/2-NF-kappa-B signaling pathway and expression of COX-2 and Bcl2. Also abolishes H(2)O(2)-triggered activation of p38 MAPK.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:20558725}. Cell surface {ECO:0000269|PubMed:20558725}.
Interaction partners:
Sequence:
MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAALAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRGALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLGRDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYTGGNGGSAGLIGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLFGNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNGQSIVIDFVRHGQTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIRTQQTAAPLANLLGMAPQVLPGLNEIHAGIFEDLPQISPAGLLYLVGPIAWTLGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIYDASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTHPVPNTGAVVVQGNPEGGWTLVSWDGIPVGPASLPTALFVDVRELITAPQYAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVADDVIDATGHPYLSGLPIGLPSLIP
Protein: Focal contact protein paxillin (Q9GSE0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction, focal adhesion {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MKIDALLADLQNSVPGQPQQPQPQYGTVQPKHQALQQQQFVDNTPGYGSLRGKAQPQVYQEHYSVETRSPTAGHDFNGSSTTPGYANQGSLPRQAAGASTGLSELDSLLQDLQKIDVPVNYSTPVSKYNTMNSYATVEERPSVDSLLNELDNAHIYAVPNGSAHKSPTPGRHVTITVRETKTEKLTGPDGQLALSRSKLCSRRILIRPIMLVPGQQVHQAYTSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEETTIVEDSREDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPEHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAIMENYISALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITAMFKKFHPEHFVCAFCLKQLNKGTFKEQKDKPYCHTCFDKIFG
Protein: Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) (O15056)
Organism: Homo sapiens (Human)
Function: Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11084340}. Cell membrane {ECO:0000269|PubMed:11084340}. Membrane raft {ECO:0000269|PubMed:11084340}. Presynapse {ECO:0000250|UniProtKB:O55207}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55207}. Note=Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340). {ECO:0000269|PubMed:11084340}.
Interaction partners:
- Endophilin-A1
- Amphiphysin
- Inositol polyphosphate-4-phosphatase type I A
- Myc box-dependent-interacting protein 1
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Inositol polyphosphate 4-phosphatase type II
- Inositol polyphosphate 5-phosphatase OCRL
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- Phosphatidylinositol polyphosphate 5-phosphatase type IV
Sequence:
MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIALKKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDWLLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT