wanglab/gogpt-training-data huggingface dataset:
Protein: FI03653p (Q9VKJ6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- Myosin-2 essential light chain
- Uncharacterized protein, isoform A
- Mechanosensitive cation channel Tmem63
- Annexin B11
Sequence:
MTEAAGATNPGGAAGDAESYGKEMALQSGRPKEPTKLDDLVQYVSLHVRIPTPLTGVVLPFVPLYLSAFYLWINVTGGQENDTTNNDVITADNQTTTDNITTWNDVGFIGVLAIAFLHILTLLFCYWSVHVLAFLTCRRVKLPGANVLAKVVPTPNNGNSKIVPIRSSKLEDGSTQYYFVFQKTKYVWNEDRKTFRAVEFPVNGLLSTYSSSRGLETEEDIKRATQTYGNNEMEMVVPEFHELFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFMLIAFECTIVKQQLRNMSEIRKMGNKPYLIYAFRQNKWRHLGSDELLPGDLVSITRSQNDNIVPCDLVILRGSCIVDESMLTGESVPLMKESLESLDNLDVEMDAEGDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQGKLLRTILFGANRATENNVETFAFIAFLMVFAVAAASYVWVKGSEDPERNRYKLFLECTLILTSIIPPDLPIELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIAGLAPNGACVPIEKAEGNTVQVLACCHSLALLDDGLVGDPLEKATLAAVDWTLTKMDSVIPKRPQFKPLKIIQRYHFSSALKRMSVLAGHLIPYSNEVKHIGAVKGAPEVIQKMLREVPADYEKVYLEYARRGARVLALGIKDLGTLGAQRVREMKREEVECDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMITGDSPLTACHVARELRFTRKKLIILTPPEEDRKNNWSWVSIDGDQSYELDTKPGSKKLSHLLATHDLCITGEGLQYLQQNQPQYMRQLLPQITVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVGVSLLTSAPVKRKRTEEEQQQAAANAAAIAAQAQANANQQLTTRERALRRRQEHLNQTQARLQNALRDMEEQTMVKLGDASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVLYIDGIKFSDTQATMQGIFIAACFLFITRAKPLKTLSKVAPLPNIFNFYTISTILSQFAVHFGTLYYLTSQANILAPPREGKVKLYIDMDAEEKTKYDPNIVSSTVYIICLSLQVATIAVNYKGYPFMESLRSNRMLMYAIGASAALVILLSTGLAPELTEFFEIIDFPTDFRKTLLGVLVLDIVGAFLLDRICSFLFGETRRKSKVLNC
Protein: Forkhead box protein P1 (Forkhead-related transcription factor 1) (P58462)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9H334}. Note=Not found in the nucleolus. {ECO:0000250|UniProtKB:Q9H334}.
Interaction partners:
- Forkhead box protein P4
- T-box brain protein 1
- Nuclear receptor corepressor 2
- Nuclear factor of activated T-cells, cytoplasmic 2
Sequence:
MMQESGSETKSNGSAIQNGSSGGNHLLECGALRDTRSNGEAPAVDLGAADLAHVQQQQQQALQVARQLLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTSSNHSSLDLTSTCVSSSAPSKSSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCDDFPAFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGSLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPIHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME
Protein: PR domain zinc finger protein 1 (EC 2.1.1.-) (D4A1S2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR013212}. Cytoplasm {ECO:0000256|PIRNR:PIRNR013212}.
Interaction partners:
- [histone H3]-lysine
- Histone deacetylase 2
- Paired box 5
- Interferon regulatory factor 4
- T-box transcription factor TBX21
- Basic leucine zipper transcriptional factor ATF-like
- BTB domain and CNC homolog 2
- Signal transducer and activator of transcription 3
- Eomesodermin
- Interleukin-7 receptor subunit alpha
Sequence:
MLDLLLEKRVGTTLAAPKCNSGSVKFQGLAETSGIMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSSADGGTSVQAEASLPRNLLFKYAANNSKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTVMNLTQTESNPKQYSSEKNELYPKSVPKREYSVKEILKLDSNPSKRKDSYRSNISPYTSEKDMDGFRKNGSPDMPFYPRVVYPIRAPLPEDFLKASLAYGMERPTYITHSPLPSSTTPSPPASSSPEQSLKSASPHGSPGNTVSPVVPGPPEHRDSYSYLNVSYGSEGLGSYPGYAPAPHLPPAFIPSYNAHYPKFLLPPYGISSNGLSTMNNINGINNFSLFPRLYPVYSNLLSGGNLPHPMLNPASLPSSLPTDGARRLLPPEHPREVLVPAPHSAFSLTGAAASMKDESSPPSGSPTAGTAATSEHVVQPKATSSVMAAPSTDGAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRDRPHKCAQCHKSYIHLCSLKVHLKGNCPVVPAPGLPLEDLTRINEEIERFDLSDNADRLEDMEDSVDVTSMVEKEILAIVRKEKEETGLKMSLQKTMGSRLPSSGCSLYESSDLSLMKLPHSNSLPLVPVKVKQETVEPMDP
Protein: Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1) (Q99729)
Organism: Homo sapiens (Human)
Function: Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.
Subcellular location: Nucleus {ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Interaction partners:
- Heterogeneous nuclear ribonucleoproteins C1/C2
- Polypyrimidine tract-binding protein 1
- Heterogeneous nuclear ribonucleoprotein H
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Y-box-binding protein 1
- Heterogeneous nuclear ribonucleoprotein U
- Heterogeneous nuclear ribonucleoprotein Q
- Polyadenylate-binding protein 2
- Heterogeneous nuclear ribonucleoprotein A1
- C->U-editing enzyme APOBEC-1
Sequence:
MSEAGEEQPMETTGATENGHEAVPEASRGRGWTGAAAGAGGATAAPPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPESPTEEKIREYFGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGGGGGGQSQSWNQGYGNYWNQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY
Protein: MANSC domain-containing protein 1 (Loss of heterozygosity 12 chromosomal region 3 protein) (Q9H8J5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MFFGGEGSLTYTLVIICFLTLRLSASQNCLKKSLEDVVIDIQSSLSKGIRGNEPVYTSTQEDCINSCCSTKNISGDKACNLMIFDTRKTARQPNCYLFFCPNEEACPLKPAKGLMSYRIITDFPSLTRNLPSQELPQEDSLLHGQFSQAVTPLAHHHTDYSKPTDISWRDTLSQKFGSSDHLEKLFKMDEASAQLLAYKEKGHSQSSQFSSDQEIAHLLPENVSALPATVAVASPHTTSATPKPATLLPTNASVTPSGTSQPQLATTAPPVTTVTSQPPTTLISTVFTRAAATLQAMATTAVLTTTFQAPTDSKGSLETIPFTEISNLTLNTGNVYNPTALSMSNVESSTMNKTASWEGREASPGSSSQGSVPENQYGLPFEKWLLIGSLLFGVLFLVIGLVLLGRILSESLRRKRYSRLDYLINGIYVDI
Protein: ATP-dependent RNA helicase dbp4 (EC 3.6.4.13) (Q9UTP9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Uncharacterized protein C57A7.06
- Pre-rRNA-processing protein esf1
- Pre-rRNA-processing protein esf2
- U3 small nucleolar RNA-associated protein 22
- Uncharacterized protein C3B8.09
- Probable U3 small nucleolar RNA-associated protein 18
- ATP-dependent RNA helicase has1
- Probable nucleolar complex protein 14
- Ribosome biogenesis protein enp2 homolog
- U3 small nucleolar ribonucleoprotein protein mpp10
Sequence:
MPKNRTGRSREAREKKRKEEEEEIEELNSQIEALSETVDHFAELPLTQPTKSALKNAHFITLTEIQKQCIPSALKGRDILGAAKTGSGKTLAFIVPLIENLYRKKWTSLDGLGALVISPTRELAIQTFETLVKIGRLHSFSAGLIIGGNNYKEEKERLSRMNILVCTPGRLLQHIDQAVNFDTSGLQMLILDEADRILDMGFRTTLDAIVSSLPVHRQTMLFSATQTKSVKDLARLSLQNPDFISVHENDTSSTPSNLNQFYLTVPLTEKLDILFGFIRTHLKFKTIVFLSSCKQVRFVYETFRRMRPGISLLHLHGKQKQTTRTEVTAKFTSSRHVVLFCTDIVARGLDFPAVDWVIQLDAPEDVDTYIHRVGRTARYNRSGNALLLLLPSEEAFLKRLESKKIAVERINVKDGKKTSIRNQLQNLCFKDNDIKYIGQKAFISYLRSIYLQKDKDVFQLDKLPVEAFADSLGLPGTPKITFGKLKNHSQSQKDYNSSTSLDSSEESEVDVENKQNVRTKYDRIFERKNQDVLAAHRQRLVEVNSDEDDGDFLQVKRVDHDLPEETGERFNANSKRKEKMASSKKAMLKYKKSADKVYFDDEGNAIPFYAMNTEDTFQKAGDPAALIASHLAEERKALEKADITDKETVRQKQLEKKRRRQELERITQQDATPDEYVPEGPIVAFVDDELPETSKKQKKWFEDNDERDHGGIVEVENLNSLEDQEALALKLMGAA
Protein: Serine/threonine-protein kinase receptor sma-6 (EC 2.7.11.30) (Q09488)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase receptor which binds TGF-beta-like ligands dbl-1 and perhaps daf-7. Upon ligand binding, probably activates a TGF-beta-like signaling pathway.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Protein dbl-1
- Cell surface receptor daf-4
- Repulsive guidance molecule B homolog drag-1
- Leucine-rich repeats and immunoglobulin-like domains protein sma-10
- Dwarfin sma-2
- Dwarfin sma-3
- TGF-beta family profile domain-containing protein
- SMAll.
- Smad-related protein daf-14
- TGF-beta family profile domain-containing protein
Sequence:
MNITFIFILIFGFFNTQKCSKDYDHFDDEDLALSIPKNAIGVPKEFRQQVLKEMKLRNRPNDILKNRCYCNYDQSICGNNMTCVKQDGAACYHAVEEVYNKAEKRMETLHKWGCATLERGSGASHLTCNSWRAAHHSPKSIGCCYEGNYCNKNLIPPAYVHHHKEKALQEKTDNPEDYDSPLENMTRGGKMFIMVFATVMSVFAVIGCIYLCITRAEEKSKARARAKTVSLKTESTYMESKSMLEDSGSGSGQAALIQRTVRQDLTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWKNERDVYQTNMINHENILQFVAADIWSEEDSMTKMLLITDYHELGSLSDYLCREETLTTDEALRLIHSCICGIEHLHAAVHGTGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLALRYQNDKILPEKFNVQVGTKRYMAPELISNKLNPKDFSQFKMADIYSMALVMWEVAIRVEVNTCEEVLTVDETSPDHSASSGIGESVSSSGNISRMHLQKTNVEGHSTSLKAKQHVPPFDGIVHNDPNFDEMNDVICVRRIRPPPDLAWKNVPALNELSKLMEDSWHSIPHFRHSALKLKKEMAELIKNPDRQNQSQRKVEFQQQDSGLVESATNQS
Protein: ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) (Q9JHC9)
Organism: Mus musculus (Mouse)
Function: Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.
Subcellular location: Nucleus.
Interaction partners:
- Runt-related transcription factor 1
Sequence:
MASAVVDSGGSALELPSDGGENQEGGDTGPDCPAVIVEPVPSARLEQGYAAQVLVYDDETYMMQDVAEEQEVETENSETVEASVHSSNAHCTDKTIEAAEALLHMESPTCLRDSRSPVEVFVPPCISTPEFIHAAMRPDVITETVVEVSTEESEPMDASPIPTSPDSHEPMKKKKVGRKPKTQQSPVSNGSPELGIKKKAREGKGNTTYLWEFLLDLLQDKNTCPRYIKWTQREKGIFKLVDSKAVSKLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKDMPKNIVVIDDDKSETCPEDLAAAADDKSLERVSLSAESLLKAATAVRGGKNSSPLNCSRAEKGVARVVNITSPTHDGSSRSPTTTAPVSAAAAPRTVRVAMQVPVVMTSLGQKISAVAVQSVNAGTGSPLITSTSPASASSPKVVIQTVPTVMPASTENGDRITMQPAKIITIPATQLAQCQLQAKSNLTGSGSINIVGTPLAVRALTPVSIAHGTPVMRLSVPAQQASGQTPPRVISALLKGPEGKSEAKKQEHDVKTLQLVEEKGADGNKTVTHVVVVSAPSAIALPVTMKTEGLVTCEK
Protein: Complement component C8 beta chain (Complement component 8 subunit beta) (P07358)
Organism: Homo sapiens (Human)
Function: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Subcellular location: Secreted.
Interaction partners:
- Complement C5
- Complement component C8 gamma chain
- Complement component C8 alpha chain
- Complement component C7
- Complement component C9
- Complement component C6
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Mitochondrial inner membrane m-AAA protease component paraplegin
- Non-selective voltage-gated ion channel VDAC1
- Complement C4-A
Sequence:
MKNSRTWAWRAPVELFLLCAALGCLSLPGSRGERPHSFGSNAVNKSFAKSRQMRSVDVTLMPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQHEMDQYWGIGSLASGINLFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVESYTPQTQGKYEFILKEYESYSDFERNVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMVEDLVVLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS
Protein: Peripheral plasma membrane protein CASK (dCASK) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase) (CAKI) (Camguk) (Q24210)
Organism: Drosophila melanogaster (Fruit fly)
Function: May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII.
Subcellular location: Synaptic cell membrane {ECO:0000269|PubMed:19379781}; Peripheral membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:15901771}; Peripheral membrane protein {ECO:0000269|PubMed:15901771}. Note=Eag recruits CASK to the plasma membrane.
Interaction partners:
- X11L, isoform F
- X11Lbeta, isoform A
- Ubiquitin-related modifier 1 homolog
- Discs large 5, isoform A
- Neurexin 1, isoform F
- Liprin-alpha, isoform E
- Protein lin-7 homolog
- Disks large 1 tumor suppressor protein
- non-specific serine/threonine protein kinase
- Glutamate [NMDA] receptor subunit 1
Sequence:
MTEDEILFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPHHRLSITEVLDHPWIRDRDKLQRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDADMPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHVDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCEIFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSAGLIPSPELQEWRIACQTVDKTKQEQVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY
Protein: Agamous-like MADS-box protein AGL16 (A2RVQ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in the regulation of flowering time in long-day photoperiod. Participates in the repression of FT expression and floral transition, by interacting closely with the FLC-SVP pathways. Functions in the satellite meristemoid lineage of stomatal development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
- Agamous-like MADS-box protein AGL12
- AGAMOUS-like-56
Sequence:
MGRGKIAIKRINNSTSRQVTFSKRRNGLLKKAKELAILCDAEVGVIIFSSTGRLYDFSSSSMKSVIERYSDAKGETSSENDPASEIQFWQKEAAILKRQLHNLQENHRQMMGEELSGLSVEALQNLENQLELSLRGVRMKKDQMLIEEIQVLNREGNLVHQENLDLHKKVNLMHQQNMELHEKVSEVEGVKIANKNSLLTNGLDMRDTSNEHVHLQLSQPQHDHETHSKAIQLNYFSFIA
Protein: Interferon alpha-4 (IFN-alpha-4) (P07351)
Organism: Mus musculus (Mouse)
Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular location: Secreted.
Interaction partners:
- Interferon alpha/beta receptor 1
- Interferon regulatory factor 7
- Interferon alpha-5
- Interferon regulatory factor 3
- Interferon alpha-2
- Interferon beta
- Interferon gamma receptor 1
- Tyrosine-protein kinase JAK2
- Signal transducer and activator of transcription 1
- Epidermal growth factor receptor
Sequence:
MARLCAFLMILVMMSYYWSACSLGCDLPHTYNLGNKRALTVLEEMRRLPPLSCLKDRKDFGFPLEKVDNQQIQKAQAILVLRDLTQQILNLFTSKDLSATWNATLLDSFCNDLHQQLNDLKACVMQEPPLTQEDSLLAVRTYFHRITVYLRKKKHSLCAWEVIRAEVWRALSSSTNLLARLSEEKE
Protein: Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1) (P18621)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}.
Interaction partners:
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL36
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein eS10
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein eS24
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein eL18
Sequence:
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE
Protein: Kynureninase (EC 3.7.1.3) (C0LTN1)
Organism: Streptosporangium sibiricum
Interaction partners:
Sequence:
MESTRGWAEKEASADPLAVFAKDFLIPEGTLALNGNSLGPPAAAVPIALSNAVRQWSEHLIRGWWDDGWWDAPERVGDRIGRLMGAGPGQVVVGESASVQLFNALTAAVRLVPERRVLIADAGNFPTDRYLAASVARLLGLRLVETSMNDLPGALARHAGQVGAVLCGAVDFRTGELWDVPGLTTAIHQAGGVSVWDLSHAAGAVPVQADAAGVDLAVGCGYKYLSGGPGAPAFLYAARRHHHALDFAVTGWHGHADPFAMSASFVPADGITRARTGTPQILSLLALEAALEPLEAAGMAAVRAKSLRLADYLFALVADLDSVEIVTPRDPHRRGNHVTLRLPDAVAVAESLARRGVIVDERPPDLLRICLNGLYISWTDVYDAVTHLREVLR
Protein: Histone acetyltransferase gcn5 (EC 2.3.1.48) (Histone crotonyltransferase gcn5) (EC 2.3.1.-) (Q9UUK2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Histone acetyltransferase that acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation. In addition to histone acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and is able to mediate histone crotonylation (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- SAGA complex subunit Ada2
- SAGA complex/transcription factor TFIID complex subunit Taf10
- SAGA complex subunit Sgf73
- Probable ubiquitin carboxyl-terminal hydrolase 8
- SAGA complex subunit Ngg1
- SAGA complex subunit Sgf29
- SAGA complex subunit Spt8
- SAGA complex/transcription factor TFIID complex subunit Taf12
- SAGA complex subunit Spt7
- SAGA complex/transcription factor TFIID complex subunit Taf9
Sequence:
MSNSLNDQTRPPDSSVVDSTSSNFPNASNDSVHDKPVKQDEQSNPNVREAIANSDGQESLAVKENKDTESSSSHFVPNGVSNSKKRKLVATDLDVDFDISSVRVTEKPSVLEEKSGVIQFRVVSNDDTADSMIMLTGLKNIFMKQLPKMPKEYITRLIYDRNHLSMTIVKDNLHVVGGITYRPFEQRGFAEIVFCAIASNEQVRGYGSHLMNHLKDYVRGTTTIQHFLTYADNYAIGYFKKQGFTKEITLDKSIWVGYIKDYEGGTLMQCTMIPKIKYLEANLILAIQKAAVVSKINRITRSNVVYPGLDVFKDGPAHIEPSQVPGLMEVGWCKEMEELSKKPRPKPFFAVLEMLFTEMQNHPSSWPFMQPVSKEDVPDYYEVIEHPMDLSTMEFRLRNNQYESVEEFIRDAKYIFDNCRSYNDSNTTYYKNADRLEKFFQKKLRETEYSHLAD
Protein: aspartyl aminopeptidase (EC 3.4.11.21) (Q9LZ26)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Eukaryotic translation initiation factor 2A
- Protein EXPORTIN 1B
- Autophagy-related protein 9
Sequence:
MAAIARLPLTHSLPSIFNPSSFLSQSLSFPTYLHRSPFRSFSSVSPILCTSHRDSRSPGSDSNASIVGDLLDYLNESWTQFHATAEAKRQLLAAGFDLLSENEDWNLKPGGRYFFTRNMSCLVAFAVGEKYVPGNGFHAIAAHTDSPCLKLKPKSASSKSGYLMVNVQTYGGGLWHTWFDRDLSVAGRAIVRASDGSFVHRLVKVKRPLLRVPTLAIHLDRTVNSDGFKPNLETQLVPLLATKSDESSAESKDKNVSSKDAHHPLLMQILSDDLDCKVEDIVSLELNICDTQPSCLGGANNEFIFSGRLDNLASSFCALRALIDSCESSENLSTEHDIRMIALFDNEEVGSDSCQGAGAPTMFQAMRRIVSSLGNKQVTECTFDRAIRKSFLVSADMAHGVHPNFADKHEENHRPQLHKGLVIKHNANQRYATSGITSFLFKEVAKLHDLPIQEFVVRNDMGCGSTIGPILASGVGIRTVDCGIAQLSMHSVREICGTDDIDIAYRHFKAFYRSFSSVDKKLVVDD
Protein: Putative glycosyltransferase 7 (AtGT7) (EC 2.4.-.-) (O81007)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable glycosyltransferase that may be involved in the biosynthesis of xyloglucan.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Probable xyloglucan galactosyltransferase GT15
- Probable xyloglucan galactosyltransferase GT12
- Probable xyloglucan galactosyltransferase GT14
- Putative glucuronosyltransferase PGSIP7
- Xyloglucan-specific galacturonosyltransferase 1
Sequence:
MVSPETSSSHYQSSPMAKYAGTRTRPVVCISDVVLFLGGAFMSLILVWSFFSFSSISPNLTVKNEESSNKCSSGIDMSQDPTDPVYYDDPDLTYTIEKPVKNWDEKRRRWLNLHPSFIPGAENRTVMVTGSQSAPCKNPIGDHLLLRFFKNKVDYCRIHGHDIFYSNALLHPKMNSYWAKLPAVKAAMIAHPEAEWIWWVDSDALFTDMDFTPPWRRYKEHNLVVHGWPGVIYNDRSWTALNAGVFLIRNCQWSMELIDTWTGMGPVSPEYAKWGQIQRSIFKDKLFPESDDQTALLYLLYKHREVYYPKIYLEGDFYFEGYWLEIVPGLSNVTERYLEMEREDATLRRRHAEKVSERYAAFREERFLKGERGGKGSKRRPFVTHFTGCQPCSGDHNKMYDGDTCWNGMIKAINFADNQVMRKYGFVHSDLGKTSPLQPVPFDYPDEPW
Protein: Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2) (Q9CYZ8)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- LIM domain-binding protein 1
- LIM domain-binding protein 2
- Insulin gene enhancer protein ISL-1
- T-cell acute lymphocytic leukemia protein 1 homolog
- Single-stranded DNA-binding protein 3
Sequence:
MYGKGKSNSSAVPSDSQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRETCEHSSEAKAFHDYSAAAAPSPVLGNMPPGDGMPVGPVPPGFFQPFMSPRYPGGPRPPLRIPNQALGGVPGSQPLLPSGMDPTRQQGHPNMGGPMQRMTPPRGMVPLGPQNYGGAMRPPLNALGGPGMPGMNMGPGGGRPWPNPTNANSIPYSSASPGNYVGPPGGGGPPGTPIMPSPADSTNSGDNMYTLMNAVPPGPNRPNFPMGPGSDGPMGGLGGMESHHMNGSLGSGDMDSISKNSPNNMSLSNQPGTPRDDGEMGGNFLNPFQSESYSPSMTMSV
Protein: Exocyst complex component 4 (Exocyst complex component Sec8) (Q96A65)
Organism: Homo sapiens (Human)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular location: Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Cell projection {ECO:0000250|UniProtKB:Q62824}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26638075}. Note=Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). Localizes at the leading edge of migrating cells (By similarity). {ECO:0000250|UniProtKB:Q62824, ECO:0000269|PubMed:16213214}.
Interaction partners:
- Exocyst complex component 2
- Exocyst complex component 7
- Exocyst complex component 6
- Exocyst complex component 1
- Exocyst complex component 3
- Exocyst complex component 5
- Exocyst complex component 8
- Exocyst complex component 6B
- Ras-related protein Ral-A
- Exocyst complex component 3-like protein
Sequence:
MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELDPEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVLGYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHAISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEIICEQAAIKQATKDKKITTV