wanglab/gogpt-training-data huggingface dataset:
Protein: Fibronectin type III and SPRY domain-containing protein 2 (H0UZ81)
Organism: Cavia porcellus (Guinea pig)
Subcellular location: Nucleus {ECO:0000269|PubMed:28740084}. Sarcoplasmic reticulum {ECO:0000269|PubMed:28740084}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:28740084}. Note=In skeletal muscles and striated muscles flanks Z-disks (PubMed:28740084). Partially colocalizes with RYR2 in the sarcoplasmic reticulum (PubMed:28740084). {ECO:0000269|PubMed:28740084}.
Interaction partners:
Sequence:
MEEEAGEEPRLDRPTAPKDFHFYNMDLYDSEDRLPLFPEENTRLRRQTIQAEMTYDPKEVGNSFVDEGRMGVPAYPPYGIKRREPGWEQRDWRLEGEVETEDQDQDFSQWSMAGQSQALWESYRYTHGRASEEYECYVIPEEEDEEEAADLFCVTCRTPIRAVEKDFGEHKEHEVTPLSKALESAKEEIHKNMYKLEQQIIEMENFASHLEEVFITVEENFGRQEQNFESHYNGILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFLKVSNETLGKFLKTKTDVEIAAQPEFEDQTLDFSDVEQLMGSMNTILAPSAPVINPQAPNSATGSSVRVCWSLYADDTVESYQLSYRPVRDSLPGKEQAEFTVTVKESYCSVTNLEPNTQYEFWVIAQNRAGPSPSSEHAMYMTAPSPPIIKTEAIRSCEEAALICWESGNLNPVDSYTVELTQVEEPAASGVTESVVGIPICESLIQLQPGQSYTICVRALNVGGPSARSTPATVRTTGSYFPLNKATCHPWLTISEDGFTVIRSERKNLTQELQPQQTQFTRCVAIMGNLIPVRGRHYWEIEMDEHLDYTVGVAFEDVPKQEDLGANGFSWCMRHTFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYENSKLSFFNVDIAQHLYTFSCQLQQFVHPCFSLEKPGCLKIHNGISMPMHATFY
Protein: Zinc finger protein 432 (O94892)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:37823600}. Note=Excluded from nucleolus (PubMed:37823600). Responds to DNA damage by relocating to damage sites, this relocation is PAR-dependent (PubMed:37823600). {ECO:0000269|PubMed:37823600}.
Interaction partners:
Sequence:
MINAQELLTLEDVTVEFTWEEWQLLGPFQKDLYRDVMLEIYSNLLSMGYQVSKPDALSKLERGEEPWTMEDERHSRICPENNEVDDHLQDHLENQRMLKSVEQYHEHNAFGNTASQTKSLCLFRENHDTFELYIKTLKSNLSLVNQNKSCEINNSTKFSGDGKSFLHGNYEELYSAAKFSVSTKANSTKSQVSKHQRTHEIEKNHVCSECGKAFVKKSQLTDHERVHTGEKPYGCTLCAKVFSRKSRLNEHQRIHKREKSFICSECGKVFTMKSRLIEHQRTHTGEKPYICNECGKGFPGKRNLIVHQRNHTGEKSYICSECGKGFTGKSMLIIHQRTHTGEKPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNECGKGFTMKSRMIEHQRTHTGEKPYICSECGKGFPRKSNLIVHQRNHTVEKSYLCSECGKGFTVKSMLIIHQRTHTGEKPYTCSECGKGFPLKSRLIVHQRTHTGEKPYRCSECGKGFIVNSGLMLHQRTHTGEKPYICNECGKGFAFKSNLVVHQRTHTGEKPFMCSECGKGFTMKRYLIVHQQIHTEEKSCICSECGRGFAKETELALHKQVHTGEKPYGCNECGKGFTMKSRLIVHQRTHTGEKPFVCSECRKAFSSKRNLIVHQRTHNGNKP
Protein: Cerebral cavernous malformations protein 2 homolog (Malcavernin) (Valentine) (Q6DRP4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Krev interaction trapped protein 1
- Programmed cell death protein 10-A
- Programmed cell death protein 10-B
- Mitogen-activated protein kinase kinase kinase 3.
- Protein HEG
- Integrin beta-1-binding protein 1
- Uncharacterized protein.
- Dual specificity mitogen-activated protein kinase kinase 6
- Mitogen-activated protein kinase kinase kinase 2
- Mitogen-activated protein kinase kinase kinase 22.
Sequence:
MEEDVKKVKKPGIVSPFKRVFLKGEKGRDKKALEKSTERRALHTFSLSLPDHRIDPDILLNDYIEKEVKYLGQLTSVPGYLNPSSRTEVLQLIDNARKSHQLAGQLTSEQDAVVSLSAYNVKLVWRDGEDIILRVPIHDIAAVSYIRDDSLHLVVLKTAQEPGGSPCHSTEMSKSPTLSSLSESGAVLVEVCCLLVLAVDNKAAAEELCLLLSQVFQIVYTESTIDFLDRAIFDGATTPTRHLSIYSEDSSSKVDVKDVFEAEASTFSFQSSLEAGHSSSPSPTSAPASPQTKTASESELSTTAAELLQDYMTTLRTKLSSKEIQQFATLLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYKRTTSSASDSTTNGNGAAGGSDEGTATSEGDEWDRMISDISNDIEALGSSMDQDGVPS
Protein: SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) (Q812A2)
Organism: Mus musculus (Mouse)
Function: GTPase-activating protein for RAC1 and perhaps CDC42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons (By similarity).
Interaction partners:
- Roundabout homolog 2
- Cell division control protein 42 homolog
- Roundabout homolog 1
- Actin-binding protein WASF1
- SLIT-ROBO Rho GTPase-activating protein 2
- SLIT-ROBO Rho GTPase-activating protein 1
- Actin nucleation-promoting factor WASL
- Ras-related C3 botulinum toxin substrate 1
- Formin-like protein 1
Sequence:
MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGELSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCSQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESIKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVAESCIRFINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPADRVHPIQQILITLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHVNEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGTIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYVGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLSRGRIESPEKRRMATFGSAGSINYPDKKALTEGLSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPISSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMFPNSSSDKSGTM
Protein: Contig An08c0220, genomic contig (EC 1.10.3.2) (A2QS62)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Interaction partners:
Sequence:
MTIFLLLLGLLAPLVLCSPIRHVTPHLSHSTPIPRDMQGNSSQSPNTPWQGYDINTNYYETIPQTNVVREYWFDIVNTTAALDGVERPVLLVNGQFPGPTIEANWGDTVKVHVTNRMENNGTAIHFHGIRQLYNNQMDGVAALTQCPVPPNSSYTYVWRAEEYGSSWYHSHFSLQAWEGVFGGILIHGPSTAEYDHDLGMVFLNDWSHQTVDEMYQSVLESQNPPHFQTGLINGSNIWVTADNQTVGRRFQTEFVPGQRYRLRLVNAAMHTHFRFSIDNHDLTVIASDFVPIVPFTTNNVPIGMGQRYDIIVTANQAPDNYWIRAIPQSFCSDNANSDNIKGVLHYEGAADNSDPTSTKWDYGDDIQCLDFSLDELVPWLALDADIGGAQMAESDVDFTPFGDVPLYLWTMGGNALNISWKDPTLQQTFEDPDKMDWKASQGVIEAAIPNKWTVLVVQTDLPVPHPIHLHGHDFYLLAQGFGQFNPQNVTLKTHNPPRRDTALMTAATPENGGGGYMVIGFPADNPGVWLIHCHIGFHATEGFAQQIVERQSEFNTFFSEDLLENTCDAWDEYAKVNPYGHQYRALAGPYESGI
Protein: Liprin-gamma, isoform C (A8DYM0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Short stop, isoform H
- AT31531p
- Peripheral plasma membrane protein CASK
- ARF GTPase-activating protein Git
- AT10824p
- GH01369p
- Ras-related protein Rab-3
- FI18813p1
- Anoctamin
- non-specific serine/threonine protein kinase
Sequence:
MQINGLAAGPTMAASEPPEPPPRNPDRINASLHKLGESKIAKSLDTSVSTGLKEKAASVNNNKPIRPLLSLDSSVTASTSSGATGSGGGGAPAKPSPLVLASKRDLTPSNESSSSPSSSNGSNQTLTPPMTADNQPLQQQLQHHQHRSPAYPGKPAEAAGGVPQQQQQQQQLPNGIGSSHCNSNSNGISSTCNSGTAMIHANNSNLIAAGHLAQAAGPAHNAPSSGSALNAVDKRNANLSEPDQDLPPNLNVNLSPNPSLALGAPHSPTSAASAALLLLESCDGNRNDESRFHHLHSAPRPEATMKLREENDRLNAELLRLRRLLELSTDGAVGGVDTAPEMEAVASGEGSAAKERIERLESELRSVKNQLLTMRLERKKLRTDKSDLLGQVKQLCASLQEKEQELRDFIRNYQERVRETETTNAKISGDRDRERFQLLKQARDEAERSLALAQQLSARDLQLQRLQEQLQEARRQLTGCLSDQESLHSFAPLTPPSAASGMLSQMAAASGMGGGLAGMRGTTEDSGRGNSLSAFSGSLSGGSGATAGDRNSCSNDSGLRNSSDRESTGGELNFSDGTCDNGPCITVDPDSISLVSSQNMYQFGTPKERSPTLSPLNSAAYSRSVEQLGSPVDPEGPGNGAISRKFANASKSGPLGARNGRGGTWGSISRVFARSRNKNKALSADGVTEYADYSWNPLTEEGYAEKLRLLREASQLPIDRWRATQVLAWLEVALGMPQYSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEEQRRPEMVRYPLITQLGHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVKYDRQTLAMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSGDTMATALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSGCGVVPLTGPGGLQHYATTDRRSSGNLRISAWKGSQSSLSKAFRFNSKPHRTGDRSSFGNSTSPTPSYSSSEGGGGIYATIGHQYPNPHTNLQQQHYHHFLPPPTTAPPPIPSAGGIYSHGPPPGHRVSAPPVGGALDAVSTDPQMLYEQSRRRVKSISDIGASTSAGSVGACSLGGISASSESPE
Protein: PIP2 protein (A0T2N7)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAKDVEVGGEFQAKDYHDPPPAPLVDAQELTQWSFYRAIIAEFIAALLFLYITVLTVIGYKSQVDPDKGGQDCDGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSLVRAILYMAAQCLGAICGCGLVKAFQKSYYNKYGGGANSLADGYSTGTGLAAEIIGTFVLVYTVFSATDPKRNARDSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVMFNQDKPWDDHWIFWVGPFIGAAIAAIYHQYILRAGAAKALGSFRSSSAM
Protein: Protein IWS1 homolog (IWS1-like protein) (Q96ST2)
Organism: Homo sapiens (Human)
Function: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649, ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882}.
Interaction partners:
- Transcription elongation factor SPT6
- Transcription elongation factor SPT5
- Transcription elongation factor A protein 1
- Histone-lysine N-methyltransferase SETD2
- DNA-directed RNA polymerase II subunit RPB1
- FACT complex subunit SPT16
- RNA polymerase-associated protein LEO1
- Transcription elongation factor SPT4
- DNA-directed RNA polymerase II subunit RPB2
- RNA polymerase-associated protein CTR9 homolog
Sequence:
MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNSTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQATSKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL
Protein: TEP4 protein (Q9NFV5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRRADAFAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNIQGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEHILAKGYEFLLTRQAENGSFTEHGEYFYSSQRSLLTLTANSLLALLEEEKPNQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLPESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATECYSIKSKLCDICEGDDCKSKC
Protein: Glucokinase (Hexokinase 4) regulator (Glucokinase regulator) (A0A0C4DFN2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEIFQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLLIPLKKLFPSIISITWPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ
Protein: PI-PLC X domain-containing protein 3 (Q8BLJ3)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q63HM9}.
Interaction partners:
Sequence:
MASSQGKNELKFADWMATLPESIHSIPLTNLAIPGSHDSFSFYIDEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMSFTGQLGAGIRYFDLRISTKPRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQMLKNIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDPEKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWIRTQKPGESGINIVTADFVELGDFISTVIKLNYVFNEGEANT
Protein: TBC1 domain family member 5 (Q92609)
Organism: Homo sapiens (Human)
Function: May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:20923837}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:22354992}. Note=During starvation induced autophagy is relocalized from endosomal localization to LC3-positive autophagosomes. {ECO:0000269|PubMed:22354992}.
Interaction partners:
- Vacuolar protein sorting-associated protein 29
- Vacuolar protein sorting-associated protein 26A
- Vacuolar protein sorting-associated protein 35
- Vacuolar protein sorting-associated protein 26B
- Sorting nexin-1
- Sorting nexin-5
- Sorting nexin-2
- Sorting nexin-6
- Gamma-aminobutyric acid receptor-associated protein-like 2
- GABA type A receptor associated protein like 1
Sequence:
MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI
Protein: Facilitator of iron transport 3 (Q08907)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the uptake of non-siderophore and siderophore sources of iron. Has a role in the retention of iron in the cell wall and periplasmic space.
Subcellular location: Secreted, cell wall {ECO:0000305|PubMed:10383953}. Membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Facilitator of iron transport 2
- Siderophore iron transporter ARN2
- Ferric reductase transmembrane component 5
- Siderophore iron transporter ARN1
- Siderophore iron transporter ENB1
- Iron transport multicopper oxidase FET3
- mRNA decay factor CTH2
- Siderophore iron transporter 1
- Plasma membrane iron permease
- Iron-regulated transcriptional activator AFT1
Sequence:
MKFSSALVLSAVAATALAESITTTITATKNGHVYTKTVTQDATFVWGGEDSYASSTSAAESSAAETSAAETSAAATTSAAATTSAAETSSAAETSSADEGSGSSITTTITATKNGHVYTKTVTQDATFVWTGEGSSNTWSPSSTSTSSEAATSSASTTATTTAETSSSATSSSTAELSSYTGAADAITAGTGLMGAALAAVMLL
Protein: Synaptonemal complex protein 3 (SCP-3) (P70281)
Organism: Mus musculus (Mouse)
Function: Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.
Subcellular location: Nucleus {ECO:0000269|PubMed:16717126}. Chromosome {ECO:0000269|PubMed:16717126, ECO:0000269|PubMed:22346761, ECO:0000269|PubMed:22761579, ECO:0000269|PubMed:24287868, ECO:0000269|PubMed:30272023, ECO:0000269|PubMed:30746471, ECO:0000269|PubMed:30949703}. Chromosome, centromere {ECO:0000269|PubMed:22761579}. Note=It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres (By similarity). The phosphorylated form localizes preferentially to unsynapsed chromosomal regions (PubMed:22346761). {ECO:0000250|UniProtKB:Q60547, ECO:0000269|PubMed:22346761}.
Interaction partners:
- Synaptonemal complex protein 2
- Synaptonemal complex protein 1
- Breast cancer type 2 susceptibility protein homolog
- Synaptonemal complex central element protein 2
- Testis-expressed protein 12
- Synaptonemal complex central element protein 3
- Synaptonemal complex central element protein 1
- HORMA domain-containing protein 2
- Meiotic recombination protein REC8 homolog
- Cohesin subunit SA-3
Sequence:
MLRGCGDSDSSPEPLSKHLKMVPGGRKHSGKSGKPPLVDQPKKAFDFEKDDKDLSGSEEDVADEKAPVIDKHGKKRSAGIIEDVGGEVQNMLEKFGADINKALLAKRKRIEMYTKASFKASNQKIEQIWKTQQEEIQKLNNEYSQQFMNVLQQWELDIQKFEEQGEKLSNLFRQQQKIFQQSRIVQSQRMFAMKQIHEQFIKSLEDVEKNNDNLFTGTQSELKKEMAMLQKKVMMETQQQEMANVRKSLQSMLF
Protein: Stromal cell-derived factor 1 (C-X-C motif chemokine 12) (Q6T7B9)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MDLRALALLAFALAVISLSEEKPVSLTYRCPCRFFESNVARANIKHLKILSTPNCSLQIVARLKSNSKQVCIDPKLKWIQEYLEKALNKPRHRTHKKKQQKKRGPLCPSRATPLKSPGRKNGGSRCKRQAL
Protein: Linalool synthase TPS3, chloroplastic (EC 4.2.3.-) (Cis-ocimene synthase TPS2, chloroplastic) (EC 4.2.3.-) (Myrcene synthase TPS3, chloroplastic) (EC 4.2.3.15) (Trans-ocimene synthase TPS2, chloroplastic) (EC 4.2.3.106) (R4YZC3)
Organism: Coffea arabica (Arabian coffee)
Function: Monoterpene synthase (mono-TPS) involved in the biosynthesis of monoterpenes natural products, constituent of coffee beverage aroma. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) into linalool and beta-myrcene, and, as minor products, cis-ocimene and trans-ocimene. Not able to use geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP) as substrates.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MISSLNPLFTTHRSGVIAQQFFASSAAASINSVSSLKIAACSKTKLVDQSPLRQSGNHQLLSSDFNHLQSLKNDYAEEKYKSRCEVLKEQVKMMLDQEMDVVNQLELIDDLQRLGLSYHFGDEITSVLSGIYNRKSMNKMRNQWGLYATCLEFRLLRQHGFDVSQEIFDCFKDEKGDFRPSLCEDSKGMLYLYEASYLESENEESNLEMARRFAAKTLKKNLDEKRVDQDLVALVQHALELPLHWRMMRLEARWFIDIYEERSNRNPILLELAKLDFNIVQAAHQNDLTYTLRWWRSTCLAEKLTFARDMMVENFFWTVGIISDPQRGNGRRILTKVVALITAIDDIYDCYGTLDELEVFTTAVERWDVNSIDQLPDCMKICFLALYNFVNEMAYDALKEQGVNIIPYLRKSWADLCKAYLQEAKWFFSGEVPTLQQYLNNAWISISAPAFLVHAYFCVDYPINKDHLQYLDNYHKIIRCSAMILRLTNDLGTSPESEVLNVGDVPKSIRCYMKETGACEEKAREHLRFLITEAWKQMEEAQTLDSPFSSTFNGIAVNLARMGLCMYQHGDGHGHQNSEPRDRILSLLFEPICCLA
Protein: Uncharacterized protein C29B12.08 (O14030)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotic expression up-regulated protein 27
- UPF0321 protein PJ695.01c
Sequence:
MTKEWECRREQIIELSKINGMTIRELQARMSKMYKFDASIRSYKRVLARWGIRVHRQRFVSPRTEEAAARTASGDVSKALDELVTQLFHARQSDKDSLAQIEANFGLKLSKRALHYRRKRLALKRPPPDSHDSPNNSIPLMANSCLLSADNSSSSTTSNPNVAPPISTLPDPVATISSSSSSHLDMGAIHPPHHSSLPPHMGVDPSTMADAHNAHSSLTPPQSGYSSMPSLPYLQQPFQIPSQRFSRQQQSHPFPAAQHAVNGQPQALYPFIYQSRNVPMGSTMFASSNQSAAHPDGNNALPMDNTHANISYMQSSQSMPVNSYSYDRYTPNQPSYLESKPGNHQPSYTSEQPMYSTASVPQQISNGPTAVNGLPMNSYTPHSNHLHSPSPNSNSGPTDSLSAPNSTSSPSMAHANGASFASQYPSLNKSIFPASYSSSAEDGQNMQAPAHAYMQSSIYGVNQEQKSEYPSNLSMQSSMSIKDPSQLQRIHLYPQHSQYDPNGMTMRDHYSERIEPEAKPSDETLTVRSSRDLSVHNVGTLPVLSAAAATQAAMPHTMGPSAHDSASAPSPHMQSQQALPYQYYNPLPAMADPAQNVPQQLPPPIHSHLSDDQHIQYSYPNTFVNRFPQNIHHPSANLLDASAALNPVQNPLLMPQQNHEHSPLVRSDAALHDHGPLLPVYPDVDSRFV
Protein: Pseudokinase FAM20A (Q8CID3)
Organism: Mus musculus (Mouse)
Function: Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.
Subcellular location: Secreted {ECO:0000269|PubMed:15676076}. Golgi apparatus {ECO:0000269|PubMed:22900076}. Endoplasmic reticulum {ECO:0000269|PubMed:22900076}.
Interaction partners:
- Extracellular serine/threonine protein kinase FAM20C
- Enamelin
- Ameloblastin
- Protein FAM83H
- Amelogenin, X isoform
- Amelotin
- WD repeat-containing protein 72
Sequence:
MPGLRRDRLLALLLLGALFSADLYFHLWPQVQRQLRPGERPAACPCSGRAPSASLHSAAASRDLGTASHNFSGALPRVEHPSRGHPAPRSKLQALFAHSLYQVLEDPPLLGPEDWLLASQEALRYYRRKVARWNRRHKIYKEQFNLTSLDPPLQFRPEASWVQFHLGINSHGLYSRSSLAISKLLHDMRHFPTISADYSQDEKALLGACDCSQIVKPSGVHLKLVLRFSDFGKAMFKPMRQQREEETPEDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGRLVNVTKEILEVTKNEILQSVFFVSPANNVCFFAKCPYMCKTEYAVCGNPHLLEGSLSAFLPSLNLAPRLSVPNPWIRSYSLSGKEEWELNPLYCDTVKQIYPYNSSNRLLGIIDMAVFDFLIGNMDRHHYEMFTKFGDDGYLIHLDNARGFGRHSQDEISILAPLAQCCMIKRKTLLHLQLLAQADYRLSDVMRESLLEDQLSPVLTEPHLLALDRRLQIILKTVEDCIEAHGERRVIAEGSAQRSAPDSGQANLTS
Protein: Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney) (Vasopressin-regulated urea transporter) (Q28614)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q8R4T9}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8R4T9}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Coiled-coil domain-containing protein 172
Sequence:
MEDSSEIKVETASSRTSWIQSSVAAGGKRISRALGYITGEMKECAEGLKDKSPVFQFLDWVLRGTSQVMFVNNPLSGILIVIGLFVQNPWWAIAGCLGTVMSTLTALILSQDRSAIASGLHGYNGVLVGLLIAVFSDKGDYYWWLLLPVIVMSMSCPILSSALGTIFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTTLLQPVSSVPNITWSEIQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICLHAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAVGGMFYVITWQTHLLAVACALFAAYVGAALTNVLSVFGLPTCTWPFCISALIFLLLTTNNPAIYKLPLSKVTYPEANRTYYLTQERNRRSSTITKYQAYDVS