wanglab/gogpt-training-data huggingface dataset:
Protein: Diphthine methyl ester synthase (EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase) (P32469)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Elongation factor 2
- Diphthine--ammonia ligase
- 2-
- 2-
- Diphthine methyltransferase
- Diphthamide biosynthesis protein 3
- Diphthamide biosynthesis protein 4
- GPI mannosyltransferase 1
- Elongator complex protein 5
- Protein HMF1
Sequence:
MLYLIGLGLSYKSDITVRGLEAIKKCSRVYLEHYTSILMAASQEELESYYGKEIILADRELVETGSKQILNNADKEDVAFLVVGDPFGATTHTDLVLRAKREAIPVEIIHNASVMNAVGACGLQLYNFGQTVSMVFFTDNWRPDSWYDKIWENRKIGLHTLVLLDIKVKEQSIENMARGRLIYEPPRYMSIAQCCEQLLEIEEKRGTKAYTPDTPAVAISRLGSSSQSFKSGTISELANYDSGEPLHSLVILGRQCHELELEYLLEFADDKEKFGKDVANDQEYFKPAAWVPPTEDDSDE
Protein: WD-40 repeat-containing protein MSI4 (Altered cold-responsive gene 1 protein) (Nucleosome remodeling factor complex component 4) (Protein MULTICOPY SUPPRESSOR OF IRA1 4) (AtMSI4) (O22607)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of the flowering autonomous pathway which positively regulates flowering by promoting transcriptional repression of the flowering repressor FLC. May promote histone deacetylation at the FLC locus leading to the formation of repressive chromatin structures. Forms a histone deacetylase complex with HDA5, HDA6 and FLD that represses FLC gene expression to control flowering time. Also negatively regulates cold-responsive genes. Acts together with PDP1 and MSI5 to regulate the function of the PRC2 complex on FLC. Required for systemic acquired resistance (SAR) toward pathogenic bacteria (e.g. Pseudomonas syringae pv tomato DC3000 (avrPto)). Together with FLD and MSI4/FVE, contributes to dehydroabietinal-dependent (DA, a diterpenoid tricyclic diterpene) activation of flowering ans SAR.
Subcellular location: Nucleus {ECO:0000269|PubMed:14745447, ECO:0000269|PubMed:22960247}.
Interaction partners:
- Histone deacetylase 6
- Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM
- Histone deacetylase 5
- Lysine-specific demethylase ELF6
- Histone-lysine N-methyltransferase CLF
- Cullin-4
- DNA damage-binding protein 1a
- Histone H4
- Histone acetyltransferase type B catalytic subunit
- Histone-lysine N-methyltransferase MEDEA
Sequence:
MESDEAAAVSPQATTPSGGTGASGPKKRGRKPKTKEDSQTPSSQQQSDVKMKESGKKTQQSPSVDEKYSQWKGLVPILYDWLANHNLVWPSLSCRWGPQLEQATYKNRQRLYLSEQTDGSVPNTLVIANCEVVKPRVAAAEHISQFNEEARSPFVKKYKTIIHPGEVNRIRELPQNSKIVATHTDSPDVLIWDVETQPNRHAVLGAANSRPDLILTGHQDNAEFALAMCPTEPFVLSGGKDKSVVLWSIQDHITTIGTDSKSSGSIIKQTGEGTDKNESPTVGPRGVYHGHEDTVEDVAFSPTSAQEFCSVGDDSCLILWDARTGTNPVTKVEKAHDADLHCVDWNPHDDNLILTGSADNTVRLFDRRKLTANGVGSPIYKFEGHKAAVLCVQWSPDKSSVFGSSAEDGLLNIWDYDRVSKKSDRAAKSPAGLFFQHAGHRDKVVDFHWNASDPWTIVSVSDDCETTGGGGTLQIWRMSDLIYRPEEEVVAELEKFKSHVMTCASKP
Protein: L-methionine sulfoximine/L-methionine sulfone acetyltransferase (EC 2.3.1.-) (Methionine derivative detoxifier A) (MDDA) (A6VCX3)
Organism: Pseudomonas aeruginosa (strain PA7)
Function: Plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX), a rare amino acid, which inhibits glutamine synthetase (GlnA). Catalyzes the acetylation of L-methionine sulfoximine (MSX). It can also use L-methionine sulfone (MSO).
Interaction partners:
Sequence:
MSASIRDAGVADLPGILAIYNDAVGNTTAIWNETPVDLANRQAWFDARARQGYPILVASDAAGEVLGYASYGDWRPFEGFRGTVEHSVYVRDDQRGKGLGVQLLQALIERARAQGLHVMVAAIESGNAASIGLHRRLGFEISGQMPQVGQKFGRWLDLTFMQLNLDPTRSAP
Protein: DnaJ heat shock protein family (Hsp40) member A3 (G3V6I5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAARCSPRWFRVAVGTPRLPAAAGRGVQQPQGGVVAASLCRKLCVSAFGLSMGAHGPRALLTLRPGVRLTGTKSFPFVCTASFHTSASLAKDDYYQILGVPRNASQKDIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASSSGQGYWRGGPSVDPEELFRKIFGEFSSSPFGDFQNVFDQPQEETINTGPFVMRSTCRRCGGRGSIITNPCVVCRGAGQAKQKKRVTVPVPAGVEDGQTVRMPVGKREIFVTFRVQKSPVFRRDGADIHSDLFISIAQAILGGTAKAQGLYETINVTIPAGIQTDQKIRLTGKGIPRINSYGYGDHYIHIKIRVPKRLSSRQQNLILSYAEDETDVEGTVNGVTHTSTGGRTMDSSTGSKDRREAGEDNEGFLSKLKKIFTS
Protein: LNS2/PITP domain-containing protein (Q9XXT5)
Organism: Caenorhabditis elegans
Interaction partners:
- CTD nuclear envelope phosphatase 1 homolog
- Phosphatidate cytidylyltransferase
- Phospholipid phosphatase homolog 1.2 homolog
- Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
- Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
- O-acyltransferase
- Phospholipase
- Acyltransferase
- Acyltransferase
- Diacylglycerol kinase
Sequence:
MDYAYRVFKNVKYFYNSINPATLSGAIDVVVVEQPNGEYKSTPFHVRFGKYGVFSYSDKYVDIAVNGVEIDLKMKLADSGVAFFVEEADDQVPDYLLTSPLPEQETPQTAGPAVDKVLAESARKLEETQNENEDVDMNDIAKSRSSSPDGGQGNAREPKQEQSLSQVQRKQTLPFSSSVFSDRRYRSLPDLTVLAAETEVERTDIKKSDGKRTRKTPRPFVHSHSQCSPMEKKHFHKSNDEILRSLRRETHDMDRRIPLRKKSRVTFNQQATRPIDIKIQQYNDSDSELDSSVNSSPSPSLVDQREADRIADGALSDSEVDRQRDRNATPEPHDVTDWKWGELPETREQNKRKKQDEDAEKSTSRWSSWFWRSSTSTADEEQKEKEKLEQEEQGISLDELLNSSSNPVEIEKYLGKPPSVTSIDSGHVSRGVSQPSSPISNHDDYTPTTTPPNDKTPTRESVRFGAGNDIPSSTSATNGVRSRASSDEIFPLSEDELDDNFRPQYMQSLRLSSEKLKSLGLVFGANELRFSITTKFQGTTWCSCNIYLYKWYEQIVVSDIDGTITKSDVLGHVIPAIGGTWAHTGVAELYTRIKNNGYKMVYLSSRAIGQSHTTKQYLKSVAQDSKQLPDGPVLLSPTSIITAFRREVIERRPEEFKIAALTDLKQLFPSGNPFYAGFGNRITDVVSYEAVAVPAARILIIDPSGKVKRSDSSGLALSYKSMASDTVDYMFPPLSVHVKGDARKTERLTSTWSKPLEHSNFTHWHMTPKDVHDDELLEYEAQRKKLIAEQKAKK
Protein: Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) (Q14324)
Organism: Homo sapiens (Human)
Function: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Interaction partners:
- Titin
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin light chain 1/3, skeletal muscle isoform
- Myosin-6
- Myosin-1
- Nebulin
- Troponin T, fast skeletal muscle
- Myosin regulatory light chain 11
- Cysteine and glycine-rich protein 3
- Alpha-actinin-3
Sequence:
MPEAKPAAKKAPKGKDAPKGAPKEAPPKEAPAEAPKEAPPEDQSPTAEEPTGVFLKKPDSVSVETGKDAVVVAKVNGKELPDKPTIKWFKGKWLELGSKSGARFSFKESHNSASNVYTVELHIGKVVLGDRGYYRLEVKAKDTCDSCGFNIDVEAPRQDASGQSLESFKRTSEKKSDTAGELDFSGLLKKREVVEEEKKKKKKDDDDLGIPPEIWELLKGAKKSEYEKIAFQYGITDLRGMLKRLKKAKVEVKKSAAFTKKLDPAYQVDRGNKIKLMVEISDPDLTLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYEVAVKDEKCFTELFVKEPPVLIVTPLEDQQVFVGDRVEMAVEVSEEGAQVMWMKDGVELTREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIVEEKQLEVLQDIADLTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKTSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCSSFVIESAQREDEGRYTIKVTNPVGEDVASIFLQVVDVPDPPEAVRITSVGEDWAILVWEPPMYDGGKPVTGYLVERKKKGSQRWMKLNFEVFTETTYESTKMIEGILYEMRVFAVNAIGVSQPSMNTKPFMPIAPTSEPLHLIVEDVTDTTTTLKWRPPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVERCGFTVKNLPTGARILFRVVGVNIAGRSEPATLAQPVTIREIAEPPKIRLPRHLRQTYIRKVGEQLNLVVPFQGKPRPQVVWTKGGAPLDTSRVHVRTSDFDTVFFVRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPPINVMVKEVWGTNALVEWQAPKDDGNSEIMGYFVQKADKKTMEWFNVYERNRHTSCTVSDLIVGNEYYFRVYTENICGLSDSPGVSKNTARILKTGITFKPFEYKEHDFRMAPKFLTPLIDRVVVAGYSAALNCAVRGHPKPKVVWMKNKMEIREDPKFLITNYQGVLTLNIRRPSPFDAGTYTCRAVNELGEALAECKLEVRVPQ
Protein: Integrin beta-5 (O70309)
Organism: Mus musculus (Mouse)
Function: Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Integrin alpha-V
- Fibronectin
- Vitronectin
- Osteopontin
- Integrin alpha-5
- Integrin alpha-1
- Integrin alpha-3
- Focal adhesion kinase 1
- Talin-1
- Integrin alpha-6
Sequence:
MPRVPATLYACLLGLCALVPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEYFGNPRSITSRCDLKANLIRNGCEGEIESPASSTHVLRNLPLSSKGSSATGSDVIQMTPQEIAVSLRPGEQTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLENIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPEDLNLFFTATCQDGISYPGQRKCEGLKIGDTASFEVSVEARSCPGRQAAQSFTLRPVGFRDSLQVEVAYNCTCGCSTGLEPNSARCSGNGTYTCGLCECDPGYLGTRCECQEGENQSGYQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDVSTCKAKDGQICSDRGRCVCGQCQCTEPGAFGETCEKCPTCPDACSSKRDCVECLLLHQGKPDNQTCHHQCKDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFSYTELPNGRSNLTVLREPECGSAPNAMTILLAVVGSILLIGMALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFAFNKFNKSYNGSV
Protein: O-methyltransferase gliM (EC 2.1.1.-) (Gliotoxin biosynthesis protein M) (Q4WMJ5)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp. The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain. The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin. This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties. Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure. GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides. Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA. Gliotoxin contributes to pathogenesis during invasive aspergillosis. In macrophages and neutrophils, gliotoxin showed inhibition of various different cell functions including cytokine production, antigen presentation, phagocytosis, and production of reactive oxygen species.
Interaction partners:
- Glutathione S-transferase gliG
- Cytochrome P450 monooxygenase gliF
- N-methyltransferase gliN
- Thioredoxin reductase gliT
- C6 finger domain transcription factor gliZ
- Dipeptidase gliJ
Sequence:
MAPGLLENNTLSGTAAPRTEFKAIVNDLRELQAHVQRVQSAIEAPEVQSWLNEQLHHPDQLPDKELEQLALDLVDSMDKLQLQLVPSVSLLTDGFFGYLNSKTLWTVVEAQVADRLAENGPQPVSTLGLRCGIQPERLAQLLDTLVSNGIFAYNPADDTYSNNRASLLLCHDHWTQWHLWADLYPNEFFDVSRAMPQAVRLGESRTAAQIAYGTDLDLFEYLAKEQKLAKFQKTLGAGAVAQARGLTVDYPWEEIGSEPILDIGGGSGAFLASLLRAHPHLRGSLMDIQSVIELITPEFREPHGRFSDIGSRVQQLVVGDFTKQIPPSAVYTMKWCLHDWVDDDVLTILKNVRRSIVPSSVSRFLVVESIKSPGRSGRLPRYGDLIMMITCNGKERSLEDWKRLGELAGWKLYQVHRVRRAWPCIIDFRPM
Protein: Visual system homeobox 1 (Homeodomain protein RINX) (Retinal inner nuclear layer homeobox protein) (Transcription factor VSX1) (Q91V10)
Organism: Mus musculus (Mouse)
Function: Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (By similarity). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development.
Subcellular location: Nucleus {ECO:0000269|PubMed:17919464}.
Interaction partners:
- Transcription factor Atoh7
- Forkhead box protein N4
Sequence:
MTGRDGLSDARSRSRALAPGCPPTGSRLRSFAINDLLGLEADLPTPAEPGLRSNSGDPAEAIGSGPGPGPGLCGSCPARGALPLGLGLLCGFGAQPPSAAAAARARCLLLADLRLLPSAGPEPAVAQGPVHPPPALGSQQRSESVSTSDGDSPSEEKNDPKMSLILGKRKKRRHRTVFTAHQLEELEKAFGEAHYPDVYAREMLAAKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSADSLQGSCAPWLLGMHKKSTGMRKPESEDKLAGLWEFDHLKKGANKDEDGPERGPDETTQNPENSLEDVAIDLSSSSRQETKKMPPGSSTQLPQPPQVGAS
Protein: Protein zwilch homolog (Q95XP9)
Organism: Caenorhabditis elegans
Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules. The recruitment of spdl-1 to kinetochores relieves this inhibition. Required for embryonic development.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:20729837}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:18765790, ECO:0000269|PubMed:19109417, ECO:0000269|PubMed:20729837}. Cytoplasm, cytoskeleton, spindle {ECO:0000305}. Note=Localizes to the kinetochore during nuclear envelope breakdown and remains there until the metaphase-anaphase transition (PubMed:18765790). Localizes to kinetochores, spindle-associated rod-shaped structures and near the cell cortex in a knl-1-dependent manner in anaphase (PubMed:18765790, PubMed:20729837). {ECO:0000269|PubMed:18765790, ECO:0000269|PubMed:20729837, ECO:0000305|PubMed:18765790}.
Interaction partners:
- Centromere/kinetochore protein zw10 homolog
- Kinetochore-associated protein rod-1
- Kinetochore protein ndc-80
- Spindly-like protein spdl-1
- Kinesin-like protein
- SKA complex subunit 1
- Mitotic checkpoint serine/threonine-protein kinase bub-1
- Kinetochore protein Nuf2 homolog
- Dynactin subunit 6
- Chromatin assembly factor 1 subunit A dimerization domain-containing protein
Sequence:
MPLTIEQLKQYNEKMAAKGEEDDAPAPVLLLDKYRVRVLPLTSIPFVMNHSSVSQLSLSSEDVLVVDFPSKGTGSGAGKAEKKMIFKKKIEPMEDSFEDKENVNEGGPLMTSFLTLEKLRKGMVGDVEIIGYECETSFFDANPIPLSDGVSLQRYIRLNCSEHFSPSISTLPVWISTTSSKFPSICWLAAGRTNRNVQFAAATRVLGHFNNENSERVVKQLNQACGTSQLNKYRAVYEEIRKIATENRPAPGEVTIDVRWSTKSTLVLLEHPDNAADCTIKIDLGWGDKRFFVDDEIFEQLFFVLNLADVLANPDNEVIFPMAPPANFDDLVQEMDALVEASSREDNVFVSNENFRGGDITDKVWNIVRKCNDVKQVTLLFRNFLQALAYGKIKSHAQERNKSHLASLIRISKSSEFKIPVLERLSTIDMMMEIGVESLRRRVIDIFSSQLLYPSDELEFILQTCENDLPAGNGAMNSAAISLLPITMALATANRIYELLNEKDHVILPDLTRRILQKYTASMIEKSRRGETETEYTFETTLPLLRMYKEGFMSKRPCIWTCENSNTVGANVQARVLTSLELQPSLEHINRLVNDSRPVWTATEEKPAMIKDLNADYTVVHTIFSYLPKM
Protein: MOB kinase activator-like 1B (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) (Q8GYX0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein NLP2
- Rop guanine nucleotide exchange factor 14
- Protein NLP1
- Protein NLP3
- Protein NLP9
- Protein NLP5
- Protein NLP4
- Protein NLP8
- Growth-regulating factor 5
Sequence:
MSLFGLGRNQKTFRPKKSAPSGTKGAELRKHIDATLGSGNLREAVKLPPGEDLNEWLAVNTVDFFNQVNLLFGTLTEFCTPENCSTMTAGPKYEYRWADGVQIKKPIEVSAPKYVEYLMDWIETQLDDETIFPQKLGAAFPPNFKEVVKTIFKRLFRVYAHIYHSHFQKIVSLKEEAHLNTCFKHFILFTHEFVLIDKKELAPLQELIESIIAPY
Protein: Homeodomain interacting protein kinase, isoform D (A0A6M3Q6U2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKTSYPPKASDFVDYAVAGGGGSGFCSGLGAGLSVRATSFYGDQTVTATTDGTRHQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSPTAVITISDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLLQHAPSSSCSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVLPQPQPSIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAAAAAAAAAAASVGPPSWGPPQVYRQPSQPPPGSVGLPGSTQPPPSSVAPHPHHHSHGHHHHQAGTPLGGSPSSTAAAALLQPDIYAQGDIYRRPTVFVSQAAPSYAYANRAVVAPPPAHNSSSRQVIPSHPLPAHIQIPTQYSQFGPLSPAQVAASKHAAHFAPTNIXSFVASGEAGDNPEQSQELQQHQLQLTQCWWFMLLMQQTIIQNNSIFQAGSDDAAATAAASSDTTTTRKARRQH
Protein: Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) (Q9H8G2)
Organism: Homo sapiens (Human)
Function: Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.
Interaction partners:
- Phospholipase A-2-activating protein
- A-kinase anchor protein 17A
Sequence:
MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRSTDSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINADAYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQLELLELEMRARAIKALMKAGDIKKPA
Protein: High-affinity glucose transporter HXT2 (P23585)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: High-affinity glucose transporter. Is only indispensable for growth on low glucose-containing media, because S.cerevisiae possesses other sugar transporters.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Low-affinity glucose transporter HXT1
- High-affinity hexose transporter HXT6
- Low-affinity glucose transporter HXT4
- Probable glucose transporter HXT5
- Low-affinity glucose transporter HXT3
- High-affinity hexose transporter HXT7
- Carbon catabolite-derepressing protein kinase
- Glucose transport transcription regulator RGT1
- Regulatory protein MIG1
- Low glucose sensor SNF3
Sequence:
MSEFATSRVESGSQQTSIHSTPIVQKLETDESPIQTKSEYTNAELPAKPIAAYWTVICLCLMIAFGGFVFGWDTGTISGFVNQTDFKRRFGQMKSDGTYYLSDVRTGLIVGIFNIGCAFGGLTLGRLGDMYGRRIGLMCVVLVYIVGIVIQIASSDKWYQYFIGRIISGMGVGGIAVLSPTLISETAPKHIRGTCVSFYQLMITLGIFLGYCTNYGTKDYSNSVQWRVPLGLNFAFAIFMIAGMLMVPESPRFLVEKGRYEDAKRSLAKSNKVTIEDPSIVAEMDTIMANVETERLAGNASWGELFSNKGAILPRVIMGIMIQSLQQLTGNNYFFYYGTTIFNAVGMKDSFQTSIVLGIVNFASTFVALYTVDKFGRRKCLLGGSASMAICFVIFSTVGVTSLYPNGKDQPSSKAAGNVMIVFTCLFIFFFAISWAPIAYVIVAESYPLRVKNRAMAIAVGANWIWGFLIGFFTPFITSAIGFSYGYVFMGCLVFSFFYVFFFVCETKGLTLEEVNEMYVEGVKPWKSGSWISKEKRVSEE
Protein: Proteasome subunit alpha type (A0A140VK44)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Interaction partners:
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
Protein: 15-cis-zeta-carotene isomerase, chloroplastic (EC 5.2.1.12) (Q9SAC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Isomerase involved in the biosynthesis of carotenoids. Catalyzes the cis- to trans-conversion of the 15-cis-bond in 9,15,9'-tri-cis-zeta-carotene.
Subcellular location: Plastid, chloroplast membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Zeta-carotene desaturase, chloroplastic/chromoplastic
- 15-cis-phytoene desaturase, chloroplastic/chromoplastic
- Prolycopene isomerase, chloroplastic
- Lycopene beta cyclase, chloroplastic
- Phytoene synthase 1, chloroplastic
- Lycopene epsilon cyclase, chloroplastic
- Protein LUTEIN DEFICIENT 5, chloroplastic
- Zeaxanthin epoxidase, chloroplastic
- Carotene epsilon-monooxygenase, chloroplastic
- 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
Sequence:
MAVYHLLLSSPPSLLLLPPSPRRPNLTLIRRIPAHPRLGNSTSLLSSSSPVIRKILVRSTLREDQPIASDSESSPTLLIGEDSAAFELGKQKLVSWVYFGVVLGVVLFILNVVWIDNSTGFGKSFIDAVSNISGSPEVAMLMLILIFAIVHSGLASLRDIGEKLIGERAFRVLFAGISLPLAMSTIVYFINHRYDGSQLWQLQGVPGVHEAIWVANFVSFFFLYPSTFNLLEVAAVDKPKMHLWETGIMRITRHPQMVGQIVWCLAHTLWIGNTVAASASLGLIAHHLFGAWNGDRRLAKRYGEDFESIKKRTSVIPFAAIFEGRQVLPEDYYKEFVRLPYLAITALTVGAYFAHPLMQGASFRLHW
Protein: Progonadoliberin-1 (Progonadoliberin I) (B7TCA8)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MEKPRRMVATVLLCVLAVGLGLAQHWSYGLQPGGKRSTQLLLGPFQEIANEMEKLEEEQQSACPGSHQNSRSGALREAMERLLEEQGRRKNV
Protein: Fatty acid-binding protein, intestinal (B5X708)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MTYNGTWKVDRSENYEKFMEQMGVNMVKRKLAAHDNLKITLEQTGDKFVVKEASSFRTLDMEFTLGVTFEYALADGTMLSGSWGMEGDMMKGTFTRKDNGKVLKTTRAIVGEELVQSYSYGGVEAKRIFKRG
Protein: Myogenic factor 6 (Myf-6) (Class C basic helix-loop-helix protein 4) (bHLHc4) (Muscle-specific regulatory factor 4) (P23409)
Organism: Homo sapiens (Human)
Function: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
Subcellular location: Nucleus.
Interaction partners:
- Myogenic factor 5
- Myoblast determination protein 1
- Transcription factor E2-alpha
- Transcription factor 12
- Paired box protein Pax-3
- Myogenin
- Myocyte-specific enhancer factor 2A
- Transcription factor 4
- Paired box protein Pax-7
- Myosin-2
Sequence:
MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPPEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPFSYRPKQENLEGADFLRTCSSQWPSVSDHSRGLVITAKEGGASIDSSASSSLRCLSSIVDSISSEERKLPCVEEVVEK
Protein: Intraflagellar transport protein 20 homolog (Q8TA52)
Organism: Caenorhabditis elegans
Function: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility.
Subcellular location: Cell projection, cilium {ECO:0000305|PubMed:28479320}.
Interaction partners:
- GRIP domain-containing protein
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 81 homolog
- TRAF3-interacting protein 1
- Tetratricopeptide repeat protein 21 homolog
- Intraflagellar transport protein 52 C-terminal domain-containing protein
- WD_REPEATS_REGION domain-containing protein
- Intraflagellar transport protein che-13
- Clusterin-associated protein 1 homolog
- Rab8
Sequence:
MGDEQLAKAGLFVDDFNRLRLIDPDVAELLQSAQDKSSEFNDQLKNFQTTTGGLIDSIEEFANVVETEKIRAMMVRNTQERDLAEDDPVLLQMTIRELTVEKERLRVELEAVRKIEKEQDECIQMMTEH