wanglab/gogpt-training-data huggingface dataset:
Protein: FI20184p1 (Z band alternatively spliced PDZ-motif protein 66, isoform N) (E1JI73)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MTTSRSSASASFSRPAFWKVPGYELPTSYRPQPTPKPPLVPLPSPCRRRSSSGLKKRVHFADEQNVGVQVGSPAHGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRDNKIAYTQGATQEAGPGSRSNSTLPPVTPDLMPHRGPSPFLPGPSHFERALQLPVDTLPQTVFPQLNSSGGYEVPSTVFSPKPTRDHQQDVDEEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAHPGHDYHDSIMKQRVADTMLHKVVGSEADTGRVFHKQFNSPIGLYSNNNIEDTIRSTVPYKKTVQYDPRNSETYRAIQEEGGYSNYGQSSPQEVTIPVQTKVYQPNRLVPGKKPVSAPVSRPPYNVVNTHDENIRQSGSFNRLMYSVIGATEY
Protein: Splicing factor 3B subunit 4 (Q8QZY9)
Organism: Mus musculus (Mouse)
Function: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q15427}.
Interaction partners:
- Splicing factor 3A subunit 3
- Splicing factor 3B subunit 5
- Splicing factor 3B subunit 3
- Splicing factor 3A subunit 2
- PHD finger-like domain-containing protein 5A
- Splicing factor 3B subunit 1
- Splicing factor 3B subunit 6
- Splicing factor 3B subunit 2
- Splicing factor 3A subunit 1
- U5 small nuclear ribonucleoprotein 200 kDa helicase
Sequence:
MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAGGHGPPAAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRGPLPQ
Protein: Mitochondrial import inner membrane translocase subunit TIM10 (Mitochondrial intermembrane protein MRS11) (P87108)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM9, it may function as a substrate sensor.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:8955274, ECO:0000269|PubMed:9236772, ECO:0000269|PubMed:9889188}; Peripheral membrane protein {ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:8955274, ECO:0000269|PubMed:9236772, ECO:0000269|PubMed:9889188}; Intermembrane side {ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:8955274, ECO:0000269|PubMed:9236772, ECO:0000269|PubMed:9889188}. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM13
- Mitochondrial import inner membrane translocase subunit TIM8
- Mitochondrial import inner membrane translocase subunit TIM12
- Mitochondrial import inner membrane translocase subunit TIM9
- Mitochondrial import inner membrane translocase subunit TIM54
- Mitochondrial import inner membrane translocase subunit TIM22
- Mitochondrial import inner membrane translocase subunit TIM18
- Mitochondrial intermembrane space import and assembly protein 40
- Mitochondrial FAD-linked sulfhydryl oxidase ERV1
- Mitochondrial import receptor subunit TOM40
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
Protein: Potassium channel subfamily T member 2 (KNa1.2) (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) (Q6UVM3)
Organism: Homo sapiens (Human)
Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29069600}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MVDLESEVPPLPPRYRFRDLLLGDQGWQNDDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLENPSQGNEWSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKGNIWEQILRIPFILEIINAVPFIISIFWPSLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDDAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLIGVRREDNKNILLNPGPRYIMNSTDICFYINITKEENSAFKNQDQQRKSNVSRSFYHGPSRLPVHSIIASMGTVAIDLQDTSCRSASGPTLSLPTEGSKEIRRPSIAPVLEVADTSSIQTCDLLSDQSEDETTPDEEMSSNLEYAKGYPPYSPYIGSSPTFCHLLHEKVPFCCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPPDMHFLDAICWFPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMISITRLLLGLDTTPGSGFLCSMKITADDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSESQISISVEEWEDTKDSKEQGHHRSNHRNSTSSDQSDHPLLRRKSMQWARRLSRKGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRIELNDVVYLIRPDPLAYLPNSEPSRRNSICNVTGQDSREETQL
Protein: 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) (2-keto-3-deoxygluconokinase) (3-deoxy-2-oxo-D-gluconate kinase) (KDG kinase) (Q704D0)
Organism: Thermoproteus tenax
Function: Involved in the degradation of glucose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) yielding 2-keto-3-deoxy-6-phosphogluconate (KDPG).
Interaction partners:
Sequence:
MAEGRCSQGKEPAEAMISLVALGEPLIQLNAVTPGPLRYVAYFEKHVAGSEANFCIAATMAGARCSLIARVGDDEFGRNIVEYLRGRGVDVSHVKVDPGAPTGIYFVQRHFPVPGRSRLIYYRKGSAGSRVGPDDVDSSLISSADAVHSTGITLALSDSANRAVHKAFGEAKRRTFDTNIRPALWPDLAAARRAILDVLNYGVDVLVTDPDDTQILLGVRDPEEAYRKYRELGVQTLVYKLGAEGAYVFWNGGSYFRDALKVAVEDPTGAGDAVAGYFVALYLSGVDPRRALDLAVAASALVVGVRGDNEALPSPREAEELLKAL
Protein: NADH-cytochrome b5 reductase (EC 1.6.2.2) (X2JGK6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Sulfite oxidase, mitochondrial
- Cytochrome b5
- Dihydroorotate dehydrogenase
- Dihydropyrimidine dehydrogenase [NADP
- Cytochrome b5
- FI21247p1
- Multifunctional protein r
- GEO11555p1
- FAD-binding FR-type domain-containing protein
- Uncharacterized protein, isoform B
Sequence:
MARIVESNFVPLAVGVVAVLAGALIVHYLLNKKSTKPRREPNRTARLRTLVDPNDKYLLPLIEKENLSHDTRRFRFGLPSKQHVLGLPVGQHIHLIATIDNELIIRPYTPISSDEDVGYVDLVVKVYFKDSHPKFPAGGKMTQHLEQLELGDKISFRGPSGRLQYLGNGTFSIKKLRKDPPKHVTAKRVNMIAGGTGITPMLQLAREVLKRSDKDKTELALLFANQSEKDILLRAELDELAQKHPDQFKIWYTVDKANEAIKRMPRMGNARFVAWSYNTGHVNDDMMQQHLYPPGEDTLCLLCGPPPMVNYTCIPGLERLGHRAEQRFSY
Protein: RNA-binding protein rnp-4 (RNA-binding protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein rnp-4) (Q21832)
Organism: Caenorhabditis elegans
Function: RNA-binding protein which binds to pre-mRNA, spliced mRNA and spliceosomal snRNAs. Preferentially binds to the spliceosomal snRNP U2. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (By similarity). Positively regulates the nuclear export of spliced mRNAs including the sex determination gene tra-2. Promotes oogenesis by repressing germline masculinization and spermatogenesis. Required for embryonic development, possibly through positively regulating the expression of pie-1. Not required for the spatial patterning of pie-1 in embryos.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14706697}. Nucleus {ECO:0000269|PubMed:14706697}. Nucleus speckle {ECO:0000255|RuleBase:RU361239}.
Interaction partners:
- RNA helicase
- Partner of Y14 and mago
- Protein CASC3
- Protein mago nashi homolog
- MIF4G domain-containing protein
- RRM domain-containing protein
- Spliceosome RNA helicase DDX39B homolog
- Regulator of nonsense transcripts 1
- Nuclear cap-binding protein subunit 2
- UPF3 domain-containing protein
Sequence:
MSDNEVEMEDVVANAERSRGRGLAQSRNRERITYDVVDEESSATSGAPQRSVEGWIVFVTNIHEEATEDDVHDKFSEYGKIKNIHLNLDRRTGFLKGYALVEYETQKEANEAIDQSNDTDLLGQNVKVDWCFVKGKKTSGKR
Protein: Lectin-A (PL-A) (P84282)
Organism: Phytolacca americana (American pokeweed) (Phytolacca decandra)
Function: N-acetyl-D-glucosamine binding lectin. Shows low hemagglutinating activity towards human erythrocytes. Has low mitogenic activity towards human peripheral blood lymphocytes.
Interaction partners:
Sequence:
APECGREAHCGDDCQSQVVTRDFDDRTCPKLLCCSKDGWCGNTDANWRCGVDFGRTCPNDLCCS
Protein: Homeobox protein Nkx-2.5 (rNKx-2.5) (Homeobox protein NK-2 homolog E) (O35767)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor required for the development of the heart and the spleen (By similarity). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P42582}.
Interaction partners:
- Transcription factor GATA-4
- T-box transcription factor TBX5
- Myocyte-specific enhancer factor 2A
- Myocyte-specific enhancer factor 2C
- Heart- and neural crest derivatives-expressed protein 2
- T-box transcription factor TBX20
- Serum response factor
- Natriuretic peptides A
- Myosin-6
- Similar to Transcription factor GATA-5
Sequence:
MFPSPALTHTPFSVKDILNLEQQQRSLAAGDLSARLEATLAPASCMLAAFKPDGYSGPEAAAPGLAELRAELGPAPSPPKCSPAFPTAPTFYPRAYGDPDPAKDPRADKKELCALQKAVELDKAETDGAERRRPRRRRKPRVLFSQAQVYELERRFKQQRYLSPAERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLELLGPPPPPARRIAVPVLVRDGKPCLGDSAAYAPAYGLGLNAYGYNAYPYPGYGGAACSPAYSCAAYPAAPPAAHAPAASANSNFVNFGVGDLNTVQSPGMPQGNSGVSTLHGIRAW
Protein: H(2):CoB-CoM heterodisulfide,ferredoxin reductase subunit A (EC 1.8.98.5) (CoB--CoM heterodisulfide reductase iron-sulfur subunit A) (Q50756)
Organism: Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
Interaction partners:
- F420-non-reducing hydrogenase subunit A
- F420-non-reducing hydrogenase iron-sulfur subunit D
- H
- H
- Methyl viologen-reducing hydrogenase, subunit D-related protein
- F420-non-reducing hydrogenase subunit G
- formate dehydrogenase
- Tungsten formylmethanofuran dehydrogenase, subunit A
- Formate dehydrogenase, alpha subunit
- Methyl-coenzyme M reductase I subunit alpha
Sequence:
MAEEKKETMEEPKIGVYVCHCGVNIGGVVDVEAVRDYAAKLPNVVIAKDYKYYCSDPGQLEIQKDIKELGINRVVVAACSPRLHEPTFRRCVEEAGLNQFLFEFANIREHDSWVHMDNPEGATEKAKDLVRMAVAKARLLEPLEASKVSVDDKALVIGGGVAGIQAALDLADMGFKTYMVEKRPSISGRMGQLDKTFPTLDCSMCILAPKMVDVGKHDNIELITYAEVKEVDGYIGNFKVKIEKKPRYIDEELCTGCGSCVEVCPIEMPNYFDEGIGMTKAVYIPFPQAVPLCATIDKDYCIECMLCDEVCERGAVKHDQEPEEIEIEVGTIIVATGYDAYDPTEKLEYGYGRHTNVITGLELERMINASGPTDGKVLKPSDGEKPKRVAFIHCVGSRDEQIGKPYCSRVCCMYIMKNAQLIKDKMPDTEVTLYYMDIRAFGKGFEEFYKRSQEKYGIKFIRGRPAEVIENPDLTLTVRSEDTLLGKVTEYDYDMVVLGVGLVPPEGAETLRQTIGLSKSADGFLMEAHPKLRPVDTLTDGVYLAGVAQGPKDIPDAVAQASGAAARAAIPMVKGEVEIEPIIAVTDSDVCGGCEVCIELCPFGAISIEEGHANVNVALCKGCGTCVAACPSGAMDQQHFKTEQIMAQIEAALNEPASK
Protein: ferric-chelate reductase (NADPH) (EC 1.16.1.9) (G5EAX6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MGVDLLPPGQERQRHVHPPMNIALATPLFALAGGFLILFVGRLAIRMRHHLRLRAVLRNDDQTPFTNRNGFMAWTNRHVFYAPLFGARHSRELRIGRAHMGTVPLRIETLILALYIAINFAFFVCLVDWWEDYQEKLYQVKYAGGHLAVMNTPGLVLAAARNNPLIPLLGISFDTFNLFHRWVGRVIVVGAIIHMSAVIAGLIAEHGFETTTHIIWEVPFFIWGMIALFGFILIAIQSVSLLRHAFYEVFLHLHVALAVMSFVGLWYHLRGLEQQNVVLGTIILWGLERVTRVASLVWRNVGKQRTVADFELLPGNVIRATVTLARTGEFRAGQHMYLYVPSVGLWTSHPFSVAWTSTEEVSVDSDSNESFKMLLDRKPQTTISFLIKREDGFTRELQRKAANSDTCQFTTTVFAEGPYGGLEDLNSYGTVLLIASGVGITNTMSYLYQFLEGFSARKTAVRRVNLVWVTRSVEDLHWIDPWMKSVFTHPAIATKESFQNNRLAVSVQVYVTRKEASEASVGDSENLWAFSAPSGVSVSVGFGRPGFAVVIEREMETQVGAMAVSVCGNGCVTDDVRQAVREAQKGAKTISLHDEAFCW
Protein: Cytochrome c oxidase assembly protein COX11, mitochondrial (Q8GWR0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.
Interaction partners:
- Protoheme IX farnesyltransferase, mitochondrial
- Cytochrome c oxidase subunit 2
- Heme A synthase COX15
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 3
- Surfeit locus protein 1
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase copper chaperone 1
- Protein SCO1 homolog 1, mitochondrial
Sequence:
MSWSKACRGTRISSYLENLHRTSQYPRTILCSRYYTHGACKSNEHYLRSKRVFWGSSSSWSLNSHSATAKSMLDSAHRQYSTHSPSETKSQKMLYYLTAVVFGMVGLTYAAVPLYRTFCQATGYGGTVQRKETVEEKIARHSESGTVTEREIVVQFNADVADGMQWKFTPTQREVRVKPGESALAFYTAENKSSAPITGVSTYNVTPMKAGVYFNKIQCFCFEEQRLLPGEQIDMPVFFYIDPEFETDPRMDGINNLILSYTFFKVSEENTTETVNNNNSVPVQETN
Protein: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (EC 2.4.2.21) (N(1)-alpha-phosphoribosyltransferase) (P36562)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
Interaction partners:
- Bifunctional adenosylcobalamin biosynthesis protein CobU
- Adenosylcobinamide-GDP ribazoletransferase
- Adenosylcobalamin/alpha-ribazole phosphatase
- Corrinoid adenosyltransferase
- Siroheme synthase
Sequence:
MQILADLLNTIPAIDSTAMSRAQRHIDGLLKPVGSLGKLEVLAIQLAGMPGLNGIPHVGKKAVLVMCADHGVWEEGVAISPKEVTAIQAENMTRGTTGVCVLAEQAGANVHVIDVGIDTAEPIPGLINMRVARGSGNIASAPAMSRRQAEKLLLDVICYTQELAKNGVTLFGVGELGMANTTPAAAIVSTITGRDPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVGGFDLVGIAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIALSHLGLEPYLNMEMRLGEGSGAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS
Protein: Dof zinc finger protein DOF1.8 (AtDOF1.8) (Q84JQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- RING/U-box superfamily protein
- NAC domain containing protein 20
- Glycine-rich cell wall structural protein
- GATA transcription factor 25
Sequence:
MDTAKWPQEFVVKPMNEIVTNTCLKQQSNPPSPATPVERKARPEKDQALNCPRCNSLNTKFCYYNNYSLTQPRYFCKDCRRYWTAGGSLRNIPVGGGVRKNKRSSSNSSSSSPSSSSSSKKPLFANNNTPTPPLPHLNPKIGEAAATKVQDLTFSQGFGNAHEVKDLNLAFSQGFGIGHNHHSSIPEFLQVVPSSSMKNNPLVSTSSSLELLGISSSSASSNSRPAFMSYPNVHDSSVYTASGFGLSYPQFQEFMRPALGFSLDGGDPLRQEEGSSGTNNGRPLLPFESLLKLPVSSSSTNSGGNGNLKENNDEHSDHEHEKEEGEADQSVGFWSGMLSAGASAAASGGSWQ
Protein: Exportin-T (Exportin(tRNA)) (Karyopherin-beta) (tRNA exportin) (P33418)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Preferentially interacts with tRNAs with mature 5'- and 3'-termini and does not distinguish between intron-containing and spliced tRNAs. In the nucleus binds to tRNA and to the Ran-GTPases GSP1 or GSP2 in their active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the tRNA from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular location: Nucleus {ECO:0000269|PubMed:17544521, ECO:0000269|PubMed:8366091}. Cytoplasm {ECO:0000269|PubMed:17544521}. Note=Shuttles between the nucleus and the cytoplasm and the localization is regulated by SNF1 kinase, nutrient supply and stress. {ECO:0000269|PubMed:17544521}.
Interaction partners:
- GTP-binding nuclear protein GSP1/CNR1
- U3 small nucleolar RNA-associated protein 8
- GTP-binding nuclear protein GSP2/CNR2
- Protein MSN5
- 6-phosphogluconolactonase-like protein 1
- mRNA transport regulator MTR10
- Exportin-1
- 6-phosphogluconolactonase-like protein 2
- Cytoplasmic export protein 1
- 6-phosphogluconolactonase 4
Sequence:
MLERIQQLVNAVNDPRSDVATKRQAIELLNGIKSSENALEIFISLVINENSNDLLKFYGLSTLIELMTEGVNANPNGLNLVKFEITKWLKFQVLGNKQTKLPDFLMNKISEVLTTLFMLMYSDCNGNQWNSFFDDLMSLFQVDSAISNTSPSTDGNILLGLEFFNKLCLMINSEIADQSFIRSKESQLKNNNIKDWMRDNDIMKLSNVWFQCLKLDEQIVSQCPGLINSTLDCIGSFISWIDINLIIDANNYYLQLIYKFLNLKETKISCYNCILAIISKKMKPMDKLAFLNMINLTNELTYYHQAISMNPQIITFDNLEVWESLTKLITSFGIEFTIIIEQVNDDQKLDTLYKQSVISNVDSILLEKIIPILLEFMNNEFDSITAKTFPFWSNYLAFLKKYKASSPNFVPLHKDFLDNFQQICFKRMKFSDDEVTQDDFEEFNETVRFKLKNFQEIIVVIDPSLFLNNISQEISANLMNCKNESWQIFELTIYQIFNLSECTKNNYFGLNKNEIMTSQPSLTLVRFLNELLMMKDFLLAIDNEQIQILFMELIVKNYNFIFSTSANTANATDDDEKYLLILNIFMSSFAMFNKRENVRLRSWYLFTRFLKLTRINLKKILFANKNLVNEITNKISPLLHIKVTSINAQGTDDNDTIFDNQLYIFEGIGFIITLNNSSQELTAATANTPIDYDILDQILTPLFTQLEGCITQGASPVVILECHHILMAIGTLARGLHIGLVPENQVNNMVVNKKLINDSLIHKFSNIAEVILVTFSFFNKFENIRDASRFTFARLIPILSNKILPFINKLIELILSSTDLKSWEMIDFLGFLSQLIHMFHTDTDCYQLFNQLLTPLINKVHSIIEEIDEQHDQQSSSNKPIDTAVTATSVNKNIVVTDSYRDKILLKKAYCTFLQSFTNNSVTSILLSDINRAILPVILNDLVTYTPQEIQETSMMKVSLNVLCNFIKCFGNGTCLDNDDINKDPNLKIDGLNEYFIMKCVPIIFEIPFNPIYKFNIKEGNFKTMAYDLARLLRELFIVSSNPTTNENECVKYLTQIYLPQIQLPQELTIQLVNMLTTMGQKQFEKWFVDNFISVLKQGQ
Protein: Deoxyguanosine kinase (dGK) (EC 2.7.1.113) (DddGK) (Q54UT2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Purine-specific deoxyribonucleoside kinase that phosphorylates preferentially deoxyguanosine, as part of the deoxyribonucleotide salvage pathway.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- NADH-ubiquinone oxidoreductase 49 kDa subunit
- NADH dehydrogenase 1 alpha subcomplex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- Acyl carrier protein, mitochondrial
- Ribosomal protein/NADH dehydrogenase domain-containing protein
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase 23 kDa subunit
- NADH-ubiquinone oxidoreductase subunit 9
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase flavoprotein 2, mitochondrial
Sequence:
MFRRSLMFMISNNKNTNMVSSINTTNKVNNFSKIIILEGNISAGKTYLSSKLGDLLGYKVFLEPTATNPYLSLFYKEPSKYALIMQKWLLNQRYNTFLNALQYSLENEQGVILDRSVYSDWVFAENCRSEGLISAEGFKEYNSIRDRFLSNIPIPNVTLFLDVDPKQCLQRIQNRKRDCEQSIPLSYLSGLDNCYKKFLIEMKSKGSNVIILDWNNFGDINLVLNEINNDNFNNFNNSNNSKFNDVNYKKQQLISDIENEKNNLKEMKFFLNENNNNNNQEKIKS
Protein: U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'') (O22922)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in nuclear pre-mRNA splicing.
Subcellular location: Nucleus, Cajal body {ECO:0000269|PubMed:14740228, ECO:0000269|PubMed:15133128, ECO:0000269|PubMed:16624863}. Nucleus, nucleoplasm {ECO:0000269|PubMed:14740228, ECO:0000269|PubMed:15133128, ECO:0000269|PubMed:16624863, ECO:0000269|PubMed:19419533, ECO:0000269|PubMed:9819359}. Cytoplasm {ECO:0000269|PubMed:9819359}. Note=Present in coiled bodies and an interchromatin network. Redistributed throughout the cytoplasm upon entry into mitosis. Also detected in central nucleolar vacuole. {ECO:0000269|PubMed:9819359}.
Interaction partners:
- U2 small nuclear ribonucleoprotein A'
- Small nuclear ribonucleoprotein SmD3a
- Nuclear protein-like
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein Sm D2
- Probable small nuclear ribonucleoprotein G
- Uncharacterized protein At3g23325
- Small nuclear ribonucleoprotein SmD1a
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein SmD3b
Sequence:
MLTADIPPNQSIYIQNLNERIKKEELKRSLYCLFSQFGRILDVVALKTPKLRGQAWVTFSEVTAAGHAVRQMQNFPFYDKPMRLQYAKAKSDCLAKAEGTFVPKDKKRKQEEKVERKREDSQRPNTANGPSANGPSANNGVPAPSFQPSGQETMPPNNILFIQNLPHETTSMMLQLLFEQYPGFKEIRMIDAKPGIAFVEYEDDVQASIAMQPLQGFKITPQNPMVISFAKK
Protein: Muscle-specific beta 1 integrin-binding protein 2 (Q7ZUR6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Nicotinate phosphoribosyltransferase
- Nicotinamide-nucleotide adenylyltransferase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Nicotinamide phosphoribosyltransferase
- Nicotinamide-nucleotide adenylyltransferase
- Nicotinamide phosphoribosyltransferase
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
Sequence:
MKFIIGIGGVTNGGKTTLTDRLIKSLPNCCVVHQDDFFKPQDEIEVDEDGFKQYDVISALDMDAMMSTIHAWQHDPVKFERSHGVNNSLEIRPRAREDDGVHILIVEGFLLYTYGPLIDVFNQRYFISIPYEECKKRRSSRNYAVPDPPGLFDGHVWPMYVKHTKIMEDSGVDVAQLDGTMSKEQLYNLVYGNILNGIQNNLS
Protein: Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) (Q9DBG7)
Organism: Mus musculus (Mouse)
Function: Component of the SRP (signal recognition particle) receptor (By similarity). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (By similarity). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32916}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32916}; Cytoplasmic side {ECO:0000250|UniProtKB:P32916}. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain. {ECO:0000250|UniProtKB:P32916}.
Interaction partners:
- Signal recognition particle receptor subunit beta
- Signal recognition particle subunit SRP54
- Signal recognition particle subunit SRP72
- Signal recognition particle 19 kDa protein
- Signal recognition particle subunit SRP68
- Signal recognition particle 54 kDa protein
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL18
- Signal recognition particle 9 kDa protein
- Large ribosomal subunit protein uL5
Sequence:
MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKTKEKAKNNKKRGAKKEGSDGTLATSKTAPAEKSGLSAGPENGELSKEELIRRKREEFIQKHGKGLDKSSKSTKSDTPKEKGKKAPRVWELGGCANKEVLDYSTPTTNGTPEAALSEDINLIRGTGPGGQLQDLDCSSSDDEGATQNTKPSATKGTLGGMFGMLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLTALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA