wanglab/gogpt-training-data huggingface dataset:
Protein: Protein HIR1 (Q5ACW8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Histone chaperone ASF1
- Protein HIR2
- Hpc2p
- Histone transcription regulator 3 homolog
- Histone H2A.Z-specific chaperone CHZ1
- Uncharacterized protein
Sequence:
MQILKIPWFGHKTENKTVECYAVTINKDGTRLASGGLDGNVKIWDLTTINVFYKMADQPHKSKKDSTSTKLEESLPDKSLRRPLCSMSRHNGVVTSLKFSPDGRWLASGSDDKICLIWEKDNTQIAKSFGTDEHDLEHWTVRKRLVAHDNDIQDICWSPDGNLLVTVGLDRSVIIWNALTFEKIKRYDIHQSMVKGIVFDPANKFFATASDDRTVRIFRYYKKLNEYNNYEFQMEHVVVDPFKKSPLTSYFRRMSWSPDGQHIAVPNATNGPVPSVAIINRGNWGSDISLIGHEAPVEVCSFSPTLFQIADTPANEEIKFQTVVATGGQDRTLAIWSTCNSRPIVVCSDIVDSSITDICWSPDGETLYFSCLDGSITGVKFGARELGQPVKEDLIDQQLNRYGADRESTILPESVEQLQLEEQSKDSRAISIRRMMPIQEAKPEQTPPISTPASAAIDIERLRKQTVTMTKSGKKRVAPLLVSTSAAPKNVLQKPLEKKRRTKSSSKISQAAYLLPKMGVQTTVHGIKKKAESMSNDTEVEENNDNDDIGENVMANTNSVSDAALKRQRNRRKRKLMELKYPSSFKYISNLPEGLFNNHTLQNIEINKIYKAHSKHKDISAEISSSTAVEIDEDLVFSVVFRVFDHMRKENEVLGQTSGRIRTTIEVRNGKPWDDDISDRDFDDATKVIVTEEGNDKREYCLFFPFRVQHVLPIILNDVLKYYVLCSFHGSVQIISADTGSYRCPTFELGESVVTMRHSQGYMLVLTSSGLFYSWDLKAMKVTMTGISIAAILNNYEIGGKIVVSPIVRGLEINPQDGSPLVLLDMTNDIYGYSIDLQCWVKTVDSWYYGVGADKDLDVVLTGLVKKSKMSYEEDKVTEKIFTYKFDSSNDLEDAMRKRGQELLDLI
Protein: Col4a5 protein (Collagen, type IV, alpha 5) (Q63ZW6)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
Interaction partners:
- Collagen, type IV, alpha 6
- Collagen alpha-4
- Collagen alpha-2
- Collagen alpha-3
- Collagen alpha-1
- CD44 antigen
- Platelet glycoprotein VI
- Integrin alpha-1
- Integrin alpha-3
- Integrin alpha-8
Sequence:
MQVRGVCLAAGWFLLALCLWGQPAEAAACHGCSSGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSPLPGPKGNQGYPGPPGIQGPPGPKGISGPSGPPGPPGLMGPPGPPGPPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDIEFQKGDQGVPGDRGPPGPPGIPGPPGPPGGVKGEKGEPGEAGKRGKPGKDGETGQPGIPGLPGDPGYPGEPGRDGEKGQKGDIGPPGPPGLVIPAPGTGVTMGEKGNIGLPGLPGEKGERGFPGIQGPPGFPGPPGTAVVGPPGPPGYPGERGQKGDEGPPGICIPGSPGLDGQPGAPGLPGPPGPPGPQLPSRDEICKAGPPGPPGPPGDKGLQGERGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPPGSLGIPGEKGDKGQAGITGPKGLPGIPGPPGAPGFPGSKGDPGDVLTLPGMKGDKGELGFPGAPGLPGLPGSPGKDGLPGLPGPKGEPGGITFKGERGPPGSPGLPGLPGNMGPTGPVGFGPPGPIGEKGIQGVAGNPGQPGLPGPKGDPGQTITQPGKPGLPGSPGRDGEVGLPGDPGLPGQPGLPGIPGSKGEPGIPGIGPPGPPGPKGFPGIPGPPGAPGAPGRMGPDGPPGPPGFPGPKGEPGFGLPGPPGPPGFPGFKGTPGPKGDRGFPGPSGPPGRTGLDGLPGPKGDVGPNGQPGPVGPPGLPGIGLQGPPGPPGTPGPIGQPGLHGIPGEKGDPGPPGFDVPGLPGERGSPGLPGAPGLIGPPGSPGVPGKAGVPGFPGVKGEMGMMGPPGPPGPLGIPGRSGAPGLKGDDGMQGQPGLPGPAGEKGGKGEPGLPGPPGPMHPDFLGSKGEKGEPGLPGIPGLSGPKGYQGLPGDPGQPGLSGQPGSPGLPGPKGNPGLPGPPGLTGPPGPKGNIGDMGFPGPQGVDGPPGPPGFPGQPGSPGLPGQKGSKGEPGVSGIGLPGLPGPKGEPGLPGYPGNPGIKGSVGETGLPGLPGNPGAKGQPGLPGFPGTPGLPGPKGMNGPPGNPGFPGEPGPVGAGGRPGPPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGIPGPPGLPGLSGQKGDGGSPGLPGNPGLPGSKGEPGFQGFPGMPGPPGPPGSPGQALEGPKGNPGPQGPPGRPGPPGFQGPPGTEGPRGPPGNGGIKGERGNPGPPGQPGLPGLKGDQGPPGLPGNPGRPGLNGMKGDPGLPGVPGFPGMKGPIGVPGSTGPDGEPGLTGPPGPPGLPGPSGQSIVIKGDPGPPGIPGQPGLKGLPGLPGPQGLPGPIGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGARGLDGPPGPDGLQGPPGPPGTTSVAHGFLITRHSQTTEAPQCPRGTVHIYEGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLSTPEPMPMNMEPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPHCPQGWDSLWIGYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANSYSFWLATVDMSDMFNKPQSETLKAGDLRTRISRCQVCMKRT
Protein: G2/mitotic-specific cyclin cig2 (P36630)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription. Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Negatively regulates conjugation via interacting with cell cycle 'start' genes. Degraded by skp1, pop1 and pop2 in the G2 and M phases of the cell cycle.
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Interaction partners:
- Cyclin-dependent kinase 1
- Cell division control protein 18
- Mitosis inhibitor protein kinase wee1
- WD repeat-containing protein srw1
- G2/mitotic-specific cyclin cdc13
- M-phase inducer phosphatase
- Cyclin-dependent kinase inhibitor rum1
- Mitosis inhibitor protein kinase mik1
- Serine/threonine-protein kinase csk1
- Cell division cycle-related protein res1/sct1
Sequence:
MALYSISKPVGSKINKHSYQDENTLVGKQALSKGTEKTKLSTNFEINLPRRTVLSDVSNVGKNNADEKDTKKAKRSFDESNLSTNEEADKPVESKFVKKLKVYSKNADPSVETLQKDRVSNVDDHLSSNPLMAEEYAPEIFEYIRKLDLKCLPNPKYMDQQKELTWKMREILNEWLVEIHSNFCLMPETLYLAVNIIDRFLSRRSCSLSKFQLTGITALLIASKYEEVMCPSIQNFVYMTDGAFTVEDVCVAERYMLNVLNFDLSYPSPLNFLRKISQAEGYDAQTRTLGKYLTEIYLFDHDLLRYPMSKIAAAAMYLSRRLLRRGPWTPKLVESSGGYEEHELKEIAYIMLHYHNKPLEHKAFFQKYSSKRFLKASIFVHQLVRQRYSVNRTDDDDLQSEPSSSLTNDGH
Protein: GSKIP domain-containing protein (Q22757)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTQQSDKDASVSETTTPPTTPVTVKKPALCGSCDCDVEKSTLEEEAMAAVRENAFAVNLIGVSEMLPRTSQLLFINVTTFENHTHCIELTQKGWRVASNRNDCMNGDFRQLDIHTKYFESLHTLLMDISPLFRETFGSKLISKLSELKKERSDSDE
Protein: Organellar single-stranded DNA binding protein 3 (F4KBP3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MNLISRTLTRAVSSSLYHSKAAKLPTQKWIISQQIRVFSATVISGGGKKPLAKVSVKPPLNVATEKESTPPKKIEYKPEISNWINLIGFVEQPVQFGPCSDGKFWAGTVISQRSGSKSSNFWIPIIFEGDLAKIAVQHVKKEDRIHVSGKLFIDSPPPNVTYSQSNVQVMVQNLNFVQAATSTTKTISPPEKEVTSIKKKPARSKKVKVIDEETSNSWKHLIENPKEWLDHRGNKANGLVKPGHPDFKMKVGGLSLWLSTAPDWALLKLEELKFDVLVPKGNIKLNQLKDIGEESWKDLVQNPDKWLDNRSDKTNVKYPDFKHKETGEALWMTNSPIWVLSKLPPLKKNQERPFMSNKVSQLELDVEVPKGNLKQLKREEIWKNLVENPSKWWDNRLDKRNPKGPDFKHKETGEALWIGDSPTWALSKLPPLKKNQERPVMA
Protein: Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) (P53004)
Organism: Homo sapiens (Human)
Function: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666}.
Interaction partners:
- Heme oxygenase 1
- Flavin reductase
- Heme oxygenase 2
- UDP-glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase 1A8
- UDP-glucuronosyltransferase 1A7
- UDP-glucuronosyltransferase 1A10
- Protein diaphanous homolog 3
- UDP-glucuronosyltransferase 1A4
- UDP-glucuronosyltransferase 1A6
Sequence:
MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLEDALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKVLHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLFGELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLENVPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK
Protein: Protein SUO (F4JCS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00649}.
Interaction partners:
- Enhancer of mRNA-decapping protein 4
- Probable glutamate carboxypeptidase AMP1
- Katanin p60 ATPase-containing subunit A1
- Double-stranded RNA-binding protein 2
- Protein argonaute 1
- Protein argonaute 10
Sequence:
MHGRVCERRHKSRRRHMLISSSRVIATVEGGGSSCLSLSSSTSFSKDGRKISVGDCALFKPPQDCPPFIGIIRLIIAEEEDKLKLGVNWLYRPTELKLGKGILLEAEPNELFYSFHEDNIPAASLLHPCKVAFLPRGVELPSGISSFVCRRVYDVTNERLWWLTDQDYIDDRQLEVDKLLCKTRSEMHTTLQQGGRSPKSMNSPTTSQPKDGIQNSNSFLSQGKGRKRERMDHGSESVKRERSSRVDDSGSGPLRTESGLKSEILKFTEKGGLVDSEGVEKLVQLMLPERNEKKIDLVGRAILAGVVAATDKFDCLSRFVQLRGLPVFDEWLQEVHKGKVGDGGSPKDSDRLVDDFLLVLLRALDKLPVNLNALQTCNIGKSVNHLRSHKNSEIGKKARSLVDTWKKRVEAEMDAKSGSNQGVSWPGRLSHGGRHSGGSAEANKTSSSHLHASKSVSVKQQVENNLKCVATSPGSTRSAPSPGSGGNVSKDGQQRNAGAGGVSEVLAAVKDEKSSSSSQSHNNSQSCSSEHAKTGNLCGKEDARSSTAGSTLKKCSGGSSRHRKSNNVFQGSSSSASPRGAGLSRSFSSHRNVPSEKISQSSLTSEKTLEVPLTEGSGNKLIVKLPNRGRSPAQSVSGGSLEDPAPVNSRVSSPVHAVKQELCDNNGREKNHSYRPNVSSVLNAESWQSNELKDILTGSQEAAGSPLVAGDERGGDLKDSDKASGNVKGTSSLGNEFKSGERHGGTLSSMNALIESCVRYSETNASLAGSDDVGMNLLASVAADEMSKSPVASPSVSQPPNSVMNENSTVGNNTKLMASDGLPHEQHQAVCTSVSTEQGEQHVSSSGTQLESEIKNESKTGDRDKSSNSDTEDLQRLVDQCLESNDNSDGVVASPALPTKAVKEKILNDSDSGELKDIKTDVKSEADCTSDSTKRVASSMLTECRDVSKKVDSVAVEQTPLEGVDDDKKEEKPPTALSSELVKKVEEDVPVSSGISRDMDAVSIGRPITEMVNNVAFNHMDQKDVKKIKQDCDTSVGAIKDTSAGLDSSVTKGKVEPVEGNLENSEVKERYSGLRATPGLSPKEAEDLERPNGPKTSDADGDEAGECTSAARDASSVSAAASAGSEMDARVEFDLNEGFDGDDAKHGDSNNFSGSVFLTPTPLQPVKTLPFPVAPVSSGTRASITVAAAAKGPFVPPEDLLRNKGAVGWRGSAATSAFRPAEPRKPQDVLLSINNTSTSDASTSAGKQTRTFLDFDLNVPDERVLEDLASQRSGNPTNCTSDITNSFDQVRSGVMGSALDHSSGGLDLDLNKVDDSTDMISYTMNSSHRLDSSFQQVKLPSTGGRRDFDLNDGPVGDDAAVEPSMVLNQHSRSGLPSQPSLSGIRVNGENMASFSTWFPAANAYSAVSMPPIMPERGDQPFPMIATRGPQRMLGPTTGVSSFTPEGYRGPVLSSSPAMPFQSTTFQYPVFPFGNSFPVTSANFPGASTAHMDSSSSGRACFPGVNSQILGPGVPVPSNYPRPYIVGLPNGGSNGGVLDNGAKWFRSGLDLNSGPGGHETEGRDESTLVARQLSSSASLPLKEDQARMYQMSGGVLKRKEPEGGWDGYRQSSWQ
Protein: G-protein coupled receptor daf-38 (Abnormal dauer formation protein 38) (Q9U320)
Organism: Caenorhabditis elegans
Function: G-protein coupled receptor (GPCR) that forms a heterodimer with daf-37 to control dauer formation and behavior. Required for the response to dauer inducing pheromones such as the ascarosides ascr#2, ascr#3 and ascr#5.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- G-protein coupled receptor daf-37
- Serpentine receptor class gamma
- Serpentine receptor class gamma
- Serpentine Receptor, class BC
- SRBC-64)
- Guanine nucleotide-binding protein alpha-3 subunit
- Smad protein daf-8
- Guanine nucleotide-binding protein alpha-2 subunit
Sequence:
MLLPSNLTTSTLMTSSSESYDADNPGLPPEPILSDYVEMFTLVLNFIVGAPLNLAAYTQLSERPTSTRLDLLKRSLNYSDLLVLFIYVPSRACWLLTYDWRGGDALCKIVKMFHTFAFQSSSNVIVCIAVDRLLSVLSPSHHSPNKALKRTKMMLIVAWIVALVISCPQLFIWKAYLALPEYNWSQCLQIWEIARMEKFNKPQVVPEFDAEFWYSILHISLVFWIPCIIIMLSYIIVISWVWINSRPSIRHTSSFSFHTGCDTVDTVLTRASEWNPLKTFSRHVNIKEPEKPMTTPRIVVSDETEVPLTQRPSISPSEASAVMRTGVHTSTSYNANLNRSRALRVSLLLVVAYIICWLPYNLISLIQFLDRDFFSSYLKHVHFCQQLIIFNSVVNPWLYGFFGPRRPSTTGAGRH
Protein: Autophagy-related protein 13a (AtAPG13a) (Q9SCK0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in autophagy in a nutritional condition dependent manner. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. Becomes a target of autophagy under nutrient starvation. Connects autophagy to plant nutritional status.
Subcellular location: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:21984698}.
Interaction partners:
- Autophagy-related protein 101
- Autophagy-related protein 11
- Serine/threonine-protein kinase ATG1b
- Serine/threonine-protein kinase ATG1c
- Cytochrome c-type biogenesis protein CcmE homolog, mitochondrial
- Serine/threonine-protein kinase ATG1a
- Serine/threonine-protein kinase ATG1t
- Autophagy-related protein 9
- Ubiquitin-like modifier-activating enzyme atg7
- Autophagy-related protein 13b
Sequence:
MDFPENLPSDIGRLEQIVSHFFPKALHIVLNSRIPSLQSRGRTRERLSGLNVRKSDKWFNLVMGDRPAALEKLHSWHRNILDSMIIDIILVHPISNDNLDDDDDHSDSVVRSAETVIERWVVQYENPLIMSPQSSDSATRYQKVYKKSIILLRSLYAQTRLLPAYRVSRQLSSSLASSGYDLIYKVSSFSDIFSGPVTETMKEFRFAPVEVPPGRLCASVTYRSDLSDFNLGAHITLPPRIITDYVGSPATDPMRFFPSPGRSVEGHSFTGRAGRPPLTGSSAERPHSWTSGFHRPPAQFATPNQSFSPAQSHQLSPGLHDFHWSRTDAFGDNHQLSPPFSPSGSPSTPRYISGGNSPRINVRPGTAPVTIPSSATLNRYVSSNFSEPGRNPLPPFSPKSTRRSPSSQDSLPGIALYRSSRSGESPSGLMNQYPTQKLSKDSKYDSGRFSGVLSSSDSPRFAFSRSPSRLSSQDDLDDPDCSCPFDFDDVDESGLQYSHSLDRRKTSSSISQSLPLGRRSSQDAAVGVLVHMLKTAPPLRQDSSTYMASMSGVQREGSVSGTESEFSMARSTSDALEELRNYKQLKDLLLSKSKSGSGPTRVH
Protein: Receptor tyrosine kinase-like orphan receptor 2 (A1L4F5)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA
Protein: Metacaspase-5 (EC 3.4.22.-) (TcMCA5) (Q2VLK8)
Organism: Trypanosoma cruzi (strain CL Brener)
Function: Cysteine protease that cleaves specifically after arginine or lysine residues. May play a role in apoptosis.
Subcellular location: Recycling endosome {ECO:0000250|UniProtKB:Q8IEW1}. Note=Localizes to RAB11-positive recycling endosomes. {ECO:0000250|UniProtKB:Q8IEW1}.
Interaction partners:
Sequence:
MDLLLGVLSSGILQNALPFVAGVGRVKRPKRVKLEEAFREAHLCRPVIPYRAPTPYTGGRVKALFVGINYTGTRNKLSGCVNDVRQMLGTLQRIQFPISECCILVDDMRFPNFTALPTRENIIKHMAWLVHDVRPGDVLFFHYSGHGTETKAERDSEELYDQCLVPLDYQVQGAILDDDLFELLVKGLPAGVRMTAVFDCCHSASLLDLPFAFVGNNNFYSGGRHEMRKVRANNFSMGDVVVFSGCDDSGTSADVSNVSSFGSGLVASGGAATQALTWALVNTSQLSYADIFIRTREILRQKGYKQVPQLSSSKPVDLYKPFSLFGPITVNTSLIHYVPQQYLQPWGPPQPYYPPPQPQQPYYPPPQPQQPYYPSSQLPTQYNNLAPTAGIPLMTSSSEVPPGQYPQALSGDQNGGVPPQYPSDQSTYYSSAQYLSGVGKPL
Protein: Mitochondrial pyruvate carrier 1 (AtMPC1) (Q949R9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the uptake of pyruvate into mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P53157}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial pyruvate carrier 4
- Mitochondrial pyruvate carrier 3
- Mitochondrial pyruvate carrier 2
- Mitochondrial adenine nucleotide transporter ADNT1
- Protein FATTY ACID EXPORT 2, chloroplastic
- Mitochondrial dicarboxylate/tricarboxylate transporter DTC
- ADP,ATP carrier protein ER-ANT1
Sequence:
MATSRFQAFLNSPIGPKTTHFWGPIANWGFVAAGLVDMQKPPEMISGNMSSAMCVYSALFMRFAWMVQPRNYLLLACHASNETVQLYQLSRWARAQGYLSSKKEEEKPSQ
Protein: Cntn1a (Contactin-1a precursor) (A4JYP8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MIPEAFQPRAMKHTTTVLMLALSSRFWSVCADFPEVFGGESAGFGPVFEEQPLDTIYPEESPEEKITLTCRTRANPPASYRWRLNNAELVLAEGGDPHYSVSEGNLLISSPDKSKHAGNYTCVASNQYGSVTSRRARVQFGYLDMFSTDEREAVYVKEGQGAVLLCAPPPHFPEDLSFRWMLNEFPEFIPLDQRRFVSQSTGNLYISTVRSTDSGNYSCFVSSPAIAKSVFSKFIPLVPIAERSLRKYPADIKVKSPDSWALLGQNITLECFALGNPIPQIRWRKLDGVLPPLRHDVSMSGALLHLYSLQYEDEGLYECEADNSKGKDWHKTHLYVEGAPDWLEQISSSEVDIGGDYIMSCQASGKPKPHVHFLKNGHMYMKGHEVRFSRLGFEDSGMYQCVAENRHGVIHANAELRVFASAPSFQYNPVKPKLLGARNGRVVFECRPRAAPRPNITWSKGTELLHNSSRISIWLDGSLELLNISKSDEGKYTCFAENDRGRANSTGSLSITDATKITLAPSNADVSVGEDARMECVASHDPGLDLTFIWSLDGHTIDLQRDAQHYQRKMDSASGTSSSELLITHTQLRHAGRYSCTAQTPVDNTTASAELVVRGPPGPPGGVRVDEVTSDSVRVLWSHGTDNLSPISRYTVQLRESAAQQDWRDAATSPVNVEGNAEMATVVNLLPWTEYEFRVIATNTLGTGPPSEPSPKTTTREARPIVAPSDIGGGGGTSRELTITWTPVQSQYYYGSNFGYIIAFKPHNDPEWLRVTVTDPEVQKYVHKDPKIPPSTRFEVKMKAFNSQGEGPFSNSAFIYSAQDVPAEAPIITEARALSATEAIVIWVPVQLPTVERYQVRYWRESVENEASAQRVLVSSRENHTRLDNMKPDSHYLVEVRACNGAGYGPASQRNRIYTKKSPPSRPPKIISTKMHYSGSSINIAWEKVESLNNESTVAGYKVLYRQHGQPSGTLYTTEKQSIDLPMRRGEYLVEVRAHSEGGDGAVAQVRITGSAPAPALASALLLLPLLWTLML
Protein: Carbohydrate sulfotransferase 10 (EC 2.8.2.-) (HNK-1 sulfotransferase) (HNK-1ST) (HNK1ST) (Q6PGK7)
Organism: Mus musculus (Mouse)
Function: Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, confering binding specificity to extracellular matrix components (By similarity). Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O-(beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D-glucuronate) hormones (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:O54702}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
Sequence:
MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDGYSAKQEFVFLTTMPEAEKLRGEKHFPEVPKPTGKMLSDSRPDQPPVYLERLELIRNTCKEEALRNLSHTEVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHEKNGLPRLSSFSKIGIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRKNRTETRGIQFEDFVRYLGDPNRRWLDLQFGDHIIHWVTYVELCAPCEIKYSVVGHHETLEADAPYILKEAGIDHLVSYPTIPPGITMYNRTKVEQYFLGISKRDIRRLYARFEGDFKLFGYQKPDFLLN
Protein: Peptide chain release factor 1, mitochondrial (MRF-1) (MtRF-1) (P30775)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.
Subcellular location: Mitochondrion.
Interaction partners:
- Putative uncharacterized protein YOL114C
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL17m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein bL36m
Sequence:
MWLSKFQFPSRSIFKGVFLGHKLPLLVRLTSTTTNSKSNGSIPTQYTELSPLLVKQAEKYEAELKDLDKDLSCGIHFDVNKQKHYAKLSALTDTFIEYKEKLNELKSLQEMIVSDPSLRAEAEQEYAELVPQYETTSSRLVNKLLPPHPFADKPSLLELRPGVGGIEAMIFTQNLLDMYIGYANYRKWKYRIISKNENESGSGIIDAILSIEEAGSYDRLRFEAGVHRVQRIPSTETKGRTHTSTAAVVVLPQIGDESAKSIDAYERTFKPGEIRVDIMRASGKGGQHVNTTDSAVRLTHIPSGIVVSMQDERSQHKNKAKAFTILRARLAEKERLEKEEKERKARKSQVSSTNRSDKIRTYNFPQNRITDHRCGFTLLDLPGVLSGERLDEVIEAMSKYDSTERAKELLESN
Protein: Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3) (Q9UBP4)
Organism: Homo sapiens (Human)
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Dickkopf-related protein 2
- Low-density lipoprotein receptor-related protein 5
- Dickkopf-related protein 1
- Protein Wnt-6
- Protein Wnt-2b
- Kremen protein 1
- Secreted frizzled-related protein 1
- Frizzled-8
- Wnt inhibitory factor 1
- Secreted frizzled-related protein 2
Sequence:
MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILLPREVPDEYEVGSFMEEVRQELEDLERSLTEEMALREPAAAAAALLGGEEI
Protein: Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) (O15511)
Organism: Homo sapiens (Human)
Function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079}. Cell projection {ECO:0000269|PubMed:9230079}. Nucleus {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:37349293}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 1A
- Actin-related protein 2/3 complex subunit 4
- Actin nucleation-promoting factor WAS
- Actin nucleation-promoting factor WASL
- NCK-interacting protein with SH3 domain
Sequence:
MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV
Protein: LD26007p (Meso18E protein) (Meso18E, isoform A) (Meso18E, isoform B) (Meso18E, isoform C) (Meso18E, isoform D) (Q9V3Z3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDTKNPPPVTSSYHHQRAPRTPESYFNVPESVALLNIVKSERIQSAFQSNRKNHASVWEMVAEVLNRFSARKRTAKQCCNRYENLKKIYTQLKKNPERHVRRNWPYMFLFKEIEEQRGECWGSNGKRLALITKNHNELSYYQRRRQAAELGVLLNKDNLTPHQHSLLQSLSQSQSQSHSHAHSTDSSQSGSKLDRFLPNHFVEAQLSEVAGPVGGSASGVSGMSAGGFDENPLQMQMVQAAAAAAAVAAHKRHELQMASVGGVQMTPEDDDEDEPQRPAFKNHLHVLGHGHGLGLGHAPMDDSGEAPDFEKDCNGALNMHHQNNNHNENHISMKSEPLSEGEFNPDDIQLMQTNYNGAQNYYSPGMDANILHPDVIVDTDILSDCSSSTTLKKKRKMSTSTDGDSTNYELIEYLKRREKRDEELLKRMDAREDRLMNLLERTVVAIETLAVKRALTFPVNPTKENAPATARPLSPPPPEAQFAAPPATQEQPTSPERNGIATGRSGTIPVANQDAAIEVPDDGDSGDDVQVKDKLAKLTPKAGGDERTDGRQT
Protein: Myocyte enhancer factor 2cb (A0A2R8QP40)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALSKKENKGGESLELESALALTPLTEEKYKQINEEFDLMIKAQKIPAVPSSTYDMTIPVNNQIYPGNHNLLPLAHHGLQRNSMSPGVTHRPPSAGGLMGTDLSTGAGTSAGKDGIPTYYRNGYGNHRNSPGLLVSSGGMNKSMQAKSPPPVNLGMNSRKPDLRVLIPPGAKNNMPSINQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTSYGTEYSLSSADLSSISGFNSANTLHLGSMSGWQQHQIQNMQHSALSQLGNCSSSHLCQGSNLSLPSTQSLHIKSEPVSPPRDRSSSTTPGGYGQLPSHQQHQGPTSQGRQDSGRSPADSLSSCGSSHEGSDRDEHRPDFHSPLGLGRPGLDDQDSPSIKRIRLSEGWAT