wanglab/gogpt-training-data huggingface dataset:
Protein: Phosphorylase b kinase regulatory subunit (Q5RKH5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123}.
Interaction partners:
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
- Phosphorylase b kinase regulatory subunit
- Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
- Calmodulin-1
- Calmodulin-like protein 3
- Calmodulin-like protein 4
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Glycogen phosphorylase, muscle form
Sequence:
MAGEEGLMSEVSWKLLERRARAKRSGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKSTMLTYQSPTTGLFPTKTCGGDQKSKVHESLYCAAGAWALALAYRRIDDDKGRTHELEHSAIKCMRGVLYCYMRQADKVQQFKQDPRPTTCLHSVFNVHTGDEVLSYEEYGHLQINAVSLFLLYLVEMISSGLQIIYNTDEVSFIQNLVFCVERVYRVPDFGVWERGSKYNNGSTELHSSSVGLAKAALEAINGFNLFGNQGCSWSVIFVDLDAHNRNRQTLCSLLPRESRSHNTDAALLPCITYPAFALDDEALFSQTLDKVIRKLKGKYGFKRFLRDGYRTPLEDPNRRYYKPAEIKLFDGIECEFPIFFLYLMIDGVFRGNLEQVKEYQDLLTPLLHQTTEGYPVVPKYYYVPADFVEYEKRNPGSQKRFPSNCGRDGKLFLWGQALYIIAKLLADELISPKDIDPVHRFVPLQNQRNVSMRFSNQGPLENDLVVHVALVAESQRLQVFLNTYGIQTQTPQQVEPIQIWPQQELVKAYFHLGINEKLGLSGRPDRPIGCLGTSKIYRILGRTVVCYPIIFDLSDFYMSQDVLLLIDDIKNALQFIKQYWKMHGRPLFLVLIREDNIRGSRFNPILDMLAAFKKGIIGGVKVHVDRLQTLISGAVVEQLDFLRISDTEKLPEFKSFEELEFPKHSKVKRQSSTADAPELRQEPDITITEWKNKSTHEILQKLNDCGCLAGQTILLGILLKREGPNFITMEGTVSDHIERVYRRAGSKKLWSVVRRAASLLNKVVDSLAPSITNVLVQGKQVTLGAFGHEEEVISNPLSPRVIKNIIYYKCNTHDEREAVIQQELVIHIGWIISNNPELFSGMLKIRIGWIIHAMEYELQIRGGDKPAVDLYQLSPSEVKQLLLDILQPQQSGRCWLNRRQIDGSLNRTPPGFYDRVWQILERTPNGIVVAGKHLPQQPTLSDMTMYEMNFSLLVEDMLGNIDQPKYRQIIVELLMVVSIVLERNPELEFQDKVDLDKLVKEAFHEFQKDESRLKEIEKQVSGEARVPQNAFIVSTVEILSNLPTFQTDGQSTKEDALQAVRLTEELILLFS
Protein: Electron transfer flavoprotein subunit alpha, mitochondrial (A0A0S2Z3L0)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
MFRAAAPGQLRRAASLLRFQSTLVIAEHANDSLAPITLNTITAATRLGGEVSCLVAGTKCDKVAQDLCKVAGIAKVLVAQHDVYKGLLPEELTPLILATQKQFNYTHICAGASAFGKNLLPRVAAKLEVAPISDIIAIKSPDTFVRTIYAGNALCTVKCDEKVKVFSVRGTSFDAAATSGGSASSEKASSTSPVEISEWLDQKLTKSDRPELTGAKVVVSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVDAGFVPNDMQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADYGIVADLFKVVPEMTEILKKK
Protein: Transcription factor COE4 (Early B-cell factor 4) (EBF-4) (Olf-1/EBF-like 4) (O/E-4) (OE-4) (Q9BQW3)
Organism: Homo sapiens (Human)
Function: Transcription factor. Binds to specific sequence motif 5'-CCCNNG[GA]G-3' in regulatory elements of putative target immunoregulatory genes such as NKG7, GZMA, and TBX21. Positively modulates transcription of NKG7. May play a role in regulating FAS/CD95-mediated apoptosis in cytotoxic NK cells and T-cells, probably downstream of interleukin IL2 signaling.
Subcellular location: Nucleus {ECO:0000305|PubMed:35939714}.
Interaction partners:
- Protein O-mannosyl-transferase TMTC1
Sequence:
MFPAQDALPRSGLNLKEEPLLPAGLGSVRSWMQGAGILDASTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGAEKTNNGIHYRLRLVYNNGLRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALYGVPGSNQELLLKRAADVAEALYSTPRAPGPLAPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCSSASPRGFAPSPGSQQSGYGGGLGAGLGGYGAPGVAGLGVPGSPSFLNGSTATSPFAIMPSSPPLAAASSMSLPAAAPTTSVFSFSPVNMISAVKQRSAFAPVLRPPSSPPQACPRAHGEGLPDQSFEDSDKFHSPARGLQGLAYS
Protein: Steroidogenic acute regulatory protein, mitochondrial (StAR) (START domain-containing protein 1) (StARD1) (Q9DG10)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P51557}.
Interaction partners:
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Translocator protein
- Cytochrome P450, family 17, subfamily A, polypeptide 1
- Aromatase
- Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
- Cytochrome P450, family 11, subfamily C, polypeptide 1
- Non-selective voltage-gated ion channel VDAC1
- StAR-related lipid transfer protein 3
- STARD3 N-terminal-like.
- Melanocortin 2 receptor.
Sequence:
MLPATFKLCAGISYRHMRNMTGLRKNAMIAIHHELNKLSGPGASTWINHIRRRSSLLSSPIAEETYSEADQCYVQQGQEALQKSISILEDQDGWQTEIESINGEKVMSKVLPGIGKVFKLEVTLEQQTGDLYDELVDNMEQMGEWNPNVKQVKILQKIGQETMITHEISAETPGNVVGPRDFVNVRHAKRRGSTCFLAGMSTQHPGMPEQKGFVRAENGPTCIVMRPSADDPNKTKFTWLLSLDLKGWIPKTVINRVLSQTQVDFVNHLRDRMASGGGIDAAIAC
Protein: PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) (Q9QZP2)
Organism: Rattus norvegicus (Rat)
Function: May function as a transcription factor involved in cell differentiation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 16
- Histone deacetylase 1
- Protein arginine N-methyltransferase 5
- Histone deacetylase 3
Sequence:
MNDMNLSPVGMEQLSSSSVSNALPVSGSHLGLAASPSHSAIPAPGLPVAIPNLGPSLSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRPPPQYIHPNSINVDGNTALSITNNPSALDPYQANGNVGLELGIVSIDSRSVNTHGAQSLHPNDGHEVALDTTITMENVSRVTSPISTDGMAEELTMDGVTGEHSQIPNGSRSHEPLSVDSVSNNLTADTVGHGGVIPIHGNGLELPVVMETDHIANRVNGISDSVLSDSIHTVAMSTNSVSVALSTSHNFASLESVSLQEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVPSSLQMEDSNSNKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPIESRARLSLPKQLVLRQSIVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKAVSHVWKIYHNGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIGVPEHPDVHLCNCGKECSSYSEFKAHLTSHIHNHLPSQGHSSSHGPSHSKERKWKCSMCPQAFISPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGRRDYVCEKCTKAYLTKYHLTRHLKACKEPASSSSAQDDEDEDGDSGEDGLPGSMTTEGCRMSSAVYSADESLSAHK
Protein: Nucleobase-ascorbate transporter 1 (AtNAT1) (Q9SHZ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Purine-uracil permease NCS1
- Cytoplasmic tRNA 2-thiolation protein 2
- N-terminal acetyltransferase A complex catalytic subunit NAA10
- Adenine/guanine permease AZG1
- Adenine/guanine permease AZG2
- Protein LOW PHOTOSYNTHETIC EFFICIENCY 1
- N-terminal acetyltransferase A complex auxiliary subunit NAA15
- Uridine 5'-monophosphate synthase
- Adenylosuccinate synthetase
Sequence:
MAEISHPPMEQLQDLEYCIDSNPPWPETVLLAFQNYILMLGTSAFIPALLVPAMGGSDGDRARVIQTLLFVAGIKTLLQALFGTRLPAVVGGSLAYVVPIAYIINDSSLQKISNDHERFIHTMRAIQGALIVASSIQIILGYSQVWGLFSRFFSPLGMAPVVGLVGLGMFQRGFPQLGNCIEIGLPMLLLVIGLTQYLKHVRPFKDVPIFERFPILICVTIVWIYAVILTASGAYRGKPSLTQHSCRTDKANLISTAPWFKFPYPLQWGPPTFSVGHSFAMMSAVLVSMVESTGAYIAASRLAIATPPPAYVLSRGIGWQGIGVLLDGLFGTGTGSTVLVENVGLLGLTRVGSRRVVQVSAGFMIVFSTLGKFGAVFASIPVPIYAALHCILFGLVAAVGLSFLQFTNMNSMRNLMITGLSLFLGISIPQFFAQYWDARHYGLVHTNAGWFNAFLNTLFMSPATVGLIIAVFMDNTMEVERSKKDRGMPWWVKFRTFRGDNRNEEFYTLPFNLNRFFPPT
Protein: Replication enhancer (REn) (Q8JJT9)
Organism: Tomato yellow leaf curl virus-[Almeria]
Interaction partners:
Sequence:
MDSRTGELITAPQAENGVFIWEINNPLYFKITEHSQRPFLMNHDIISIQIRFNHNIRKVMGIHKCFLNFRIWTTLQPQTGHFLRVFRYEVLKYLDSLGVISINNVIRAVDHVLYDVLENTINVTETHDIKYKFY
Protein: Hepcidin (Q9DFD6)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).
Subcellular location: Secreted.
Interaction partners:
Sequence:
LQVLTEEVGSIDSPVGEHQQPGGESMRLPEHFRFKRXSHLSLCRWCCNCCHNKGXGFCCKF
Protein: Uncharacterized protein, isoform C (A0A0B4LHN1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQHTLIRCLGMARISLMRLQPRPTVAASGGQEAGSISKPTQPVSRSFASLPQEQDKKEQNARESLNRLPRLMDFPEIVWPSALNSLKNWITIQFIIRPYFDSEFQLKDFIYGAKQALQVVSSKLMGGDLDSLDNLVSPEAIAELRPVIQKLSMTQRRQLEIKESDIYLSFPYQEFTAGHQSDWTVNVANQFRAIDLINETI
Protein: Nodulin-like domain-containing protein (Q580N1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MTYIIDDLARVRMLASGVYTMASTAAPYCFTLMAVLLRKKYRLSQSEIATISTVGNCIGYCSFPIGALFDYAGPMVLLPLGGFLGSLGFLLFGLTFDGKIANPTLTLFCVFDAIVYSGIPTLDVATIMPAILQFPLDRGYVVLVLKTISGLGTGVLMAYFNGWFKDTTSDDVEKNNYSGFMYFIAARLLIVSLIALSVTRMPMYFPCAWRKQRLSEEEWTKRQQTLQLYMNQPAPPRRMKIAVGLVLSLLLFLTTQSLIGGYVKLPPAAYLAFSIIAVLMMASFCVVALPFQWLGRYTPVRPTDMDTIGEALEDVVTESAVATTKNEVKPLPQYSGSFWQHLLTVDLWCMWLTCFGVWGTGTVMQMNAAQIYESKSYGGKKSSTLTLYITMMSVGSAVGRVSMGFTDMVLTRRQREGLKTFPTTIALPFGPLMLCIAFLLFALLPANALILPFFLGALGNGAGWGCCVLVIRTMYSQDLGKHYHFGYSSGIVSTIALNLFMFGGMYDAEAEKLGTKPECKNPSCVKNQMLILMGVNIVAAVAAAIVHFRFSRFINAEQNRCNEPADEMSGVAAPVTEDAGQPNEGGSHSGGAAQQ
Protein: Long-chain-aldehyde dehydrogenase (EC 1.2.1.48) (Aldehyde dehydrogenase 1) (Q9FDS1)
Organism: Acinetobacter sp
Function: Aldehyde dehydrogenase that shows activity toward n-alkanals (C(4) to C(14)), with a preference for longer carbon chains. The best substrate is tetradecanal.
Interaction partners:
Sequence:
MHYVDPNQSGSKIHFKDQYENFIGGQWVAPVKGVYFDNISPVDGKSFTRIPRSSAEDIELALDAAHKAKKEWNKSSPTTRSNLLLKIADRMEANLEMLAVAETWDNGKPVRETLAADIPLAIDHFRYFAGCIRAQEGGISEIDEDTIAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNCVVIKPAEQTPVGILLVAELIQDLLPAGVLNIVNGYGAEVGRPLATSPRIAKIAFTGSTQVGQLIMQYATENIIPVTLELGGKSPNVFFADVMDHDDDFLDKTLEGFAMFALNQGEVCTCPSRALIQESIADQFMEKAIERVKRIKLGHPLDTDTMVGAQASLEQQEKILRCIDTGRQEGAEVLLGGHGRQEVGNGYYIEPTIFKGHNNMQVFQEEIFGPVLSVTTFKDFDEAIQIANDTMYGLGAGVWSRSTHTAYRAGRAIEAGRVWTNCYHIYPAHAAFGGYKKSGVGRENHKMMLDHYQQTKNLLVSYSTKAMGFF
Protein: Probable phospholipid-transporting ATPase 4 (AtALA4) (EC 7.6.2.1) (Aminophospholipid flippase 4) (Q9LNQ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in transport of phospholipids.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Adenine phosphoribosyltransferase 4
- ALA-interacting subunit 1
- ALA-interacting subunit 3
- AT-hook motif nuclear-localized protein 27
Sequence:
MARGRIRSKLRLSHIYTFGCLRPSADEGQDPHPIQGPGFSRTVYCNQPHMHKKKPLKYRSNYVSTTRYNLITFFPKCLYEQFHRAANFYFLVAAILSVFPLSPFNKWSMIAPLVFVVGLSMLKEALEDWSRFMQDVKINASKVYVHKSDGEFRRRKWKKISVGDIVKVEKDGFFPADLLLLSSSYEDGICYVETMNLDGETNLKVKRSLEVTLSLDDYDSFKDFTGIIRCEDPNPSLYTFVGNLEYERQIFPLDPSQILLRDSKLRNTPYVYGVVVFTGHDTKVMQNSTKSPSKRSRIEKTMDYIIYTLLVLLILISCISSSGFAWETKFHMPKWWYLRPEEPENLTNPSNPVYAGFVHLITALLLYGYLIPISLYVSIEVVKVLQASFINKDLHMYDSESGVPAHARTSNLNEELGQVDTILSDKTGTLTCNQMDFLKCSIAGTSYGVRSSEVEVAAAQQMAVDLDEHGEVSSRTSTPRAQARDIEVESSITPRIPIKGFGFEDIRLMDGNWLREPHTDDILLFFRILAICHTAIPELNEETGKYTYEAESPDEASFLTAASEFGFVFFKRTQSSVYVHERLSHSGQTIEREYKVLNLLDFTSKRKRMSVVVRDEEGQILLLCKGADSIIFERLAKNGKVYLGPTTKHLNEYGEAGLRTLALSYRKLDEEEYSAWNAEFHKAKTSIGSDRDELLERISDMIEKDLILVGATAVEDKLQKGVPQCIDKLAQAGLKLWVLTGDKMETAINIGYSCSLLRQGMKQICITVVNSEGASQDAKAVKDNILNQITKAVQMVKLEKDPHAAFALIIDGKTLTYALEDEMKYQFLALAVDCASVICCRVSPKQKALVTRLVKEGTGKITLAIGDGANDVGMIQEADIGVGISGVEGMQAVMASDFSIAQFRFLERLLVVHGHWCYKRIAQMICYFFYKNIAFGLTLFYFEAFTGFSGQSVYNDYYLLLFNVVLTSLPVIALGVFEQDVSSEICLQFPALYQQGKKNLFFDWYRILGWMGNGVYSSLVIFFLNIGIIYEQAFRVSGQTADMDAVGTTMFTCIIWAVNVQIALTVSHFTWIQHVLIWGSIGLWYLFVALYGMMPPSLSGNIYRILVEILAPAPIYWIATFLVTVTTVLPYFAHISFQRFLHPLDHHIIQEIKYYKRDVEDRRMWTRERTKAREKTKIGFTARVDAKIRHLRSKLNKKQSNMSQFSTQDTMSPRSV
Protein: Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21) (P20023)
Organism: Homo sapiens (Human)
Function: Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU. Participates in B lymphocytes activation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:1702139}; Single-pass type I membrane protein.
Interaction partners:
- Complement C3
- B-lymphocyte antigen CD19
- CD81 antigen
- Interferon-induced transmembrane protein 1
- Low affinity immunoglobulin epsilon Fc receptor
- Interferon alpha-1/13
- T-cell surface glycoprotein CD5
- CD27 antigen
- B-cell receptor CD22
- B-cell antigen receptor complex-associated protein alpha chain
Sequence:
MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEAREVYSVDPYNPAS
Protein: Laminin alpha 5 chain (O75079)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
PPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCK
Protein: CUP-5L (Polycystin cation channel PKD1/PKD2 domain-containing protein) (Q8T666)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004337}.
Interaction partners:
- LAMP family protein lmp-1
- Transient receptor potential channel
- Protein ced-11
- Ras-related protein Rab-7a
- Endocytosis protein RME-8
- Ras-related protein Rab
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- 1-phosphatidylinositol-3-phosphate 5-kinase
Sequence:
MSRRSTTDRSDFNDNASNASSNASRRPTINFQEIMEDLPHHERETGERLRRHLQFFFMNPMEKWKVRHQLPYKLVLQVLKIVFVTMQLILFAEMRMSHVDFLEDTTTVMRHRFLKEWNDDRDALQYPPAEGRYSVYDDQGLSEHLSFLINSYYSIRNDSFASFSYDVVSHPSGNLGAQISFESIPPIEVLIDRISNVTVNNNTYNFDIREVKDTKRLNLTETEVFQIGQSDDAVRDILATRGITFLPEDALKISTVQFKFRLRTIHYSPTAGDQKPECYKISVSIKFDNSRHTGQVHVTLSTVVSYVNVCNGRIIKGQVSGVGWSFDTLLIGGTDIFVLILCILSLILCCRALIKAHLLQIKTSDYFENVLKNKITVTDQLDFLNLWYVMIVVNDALIIIGTVAKISIEFQDFDNSLFTLTSIFLGMGALLVYVGVLRYFGFFSQYNILMLTLKRSAPNIMRFMTCAIVLYAGFLIAGWVIIGPYSMKFRTLAESSEALFSLLNGDDMFATFYTINDSNTVIKVFGTVYIYLFVSLFIYVVLSLFIAIIMDAYEVVKDRYSDGLRAIEKRGCLRDFVESNPPPSELGSPTTRSAYAPSNLLNLAAGNDSSRALRALHAIDNARDWLSSLRDGTRFQSFSNPLNDSNEDVLADQNANGNDPHNSRPSNV
Protein: Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-) (Q802Y5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU368121}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU368121}.
Interaction partners:
Sequence:
MWKWRRLMRLSNRSLMAFIFFFSMSTTCLYFIYVAPGIVNTYFFMVQAQGIMLRDNVRTIGHMIRLYTNKNSTLNGTDYPDGSNSSEYIAQPTTYLPENFTYAQNLPCPERLPSMKGQMEVNMTEVPMEEIELRLKHMDIQFGGHWKPKDCKPRWKVAILIPFRNRHERLPILFQHLTPMLQRQRLQFAFYVIEQTGTQPFNRAMLFNVGFKEAMKDLDWDCVVFHDVDHIPENDRNYYGCGQMPRHFAAKLDKYMYILPYNEFFGGVSGLTVEQFLKINGFPNAFWGWGGEDDDLWNRVHYAGFNVTRPEGDIGKYKSIPHHHRGEVQFLGRYKLLRYSKERQHLDGLNNLQYSPEISLSNLYKNITVNLNPELALIAEY
Protein: Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) (Q9NQR4)
Organism: Homo sapiens (Human)
Function: Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17488281}.
Interaction partners:
- Glutamate dehydrogenase 1, mitochondrial
- Glutamate dehydrogenase 2, mitochondrial
- L-amino-acid oxidase
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Putative aspartate aminotransferase, cytoplasmic 2
- Malate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase subunit alpha, mitochondrial
- Isocitrate dehydrogenase subunit beta, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
Sequence:
MTSFRLALIQLQISSIKSDNVTRACSFIREAATQGAKIVSLPECFNSPYGAKYFPEYAEKIPGESTQKLSEVAKECSIYLIGGSIPEEDAGKLYNTCAVFGPDGTLLAKYRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCRVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRSRAVDNQVYVATASPARDDKASYVAWGHSTVVNPWGEVLAKAGTEEAIVYSDIDLKKLAEIRQQIPVFRQKRSDLYAVEMKKP
Protein: Tight junction protein 2 (Q3ZB99)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
Interaction partners:
- Tight junction protein ZO-1
- Occludin
- Claudin-1
- Junctional adhesion molecule A
- Afadin
- Claudin-5
- Transcriptional coactivator YAP1
- Rap guanine nucleotide exchange factor 2
- WW domain containing transcription regulator 1
- Gap junction alpha-1 protein
Sequence:
MEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEMMDEFDGRSFRSGYSERSRHSSHDMLSHSWEDSRERGRPHQRAQSRERERSRGRSLERGLDHEDYGRSHERSRGRSLERGLDRDFVSRDYSRGRSIDRDYDRDYERSYHQAYEPDYEGRYSPSYDRRAHPETRYERSRSREHLRSRSPTPESRSRQEHKGQHDPDRPIGVLLTKSKANEEYGLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIPSLNDSDSEVEDISEIESNRSFSPEERRQQYSDQEYHSSTEKLKERPSSREETSGRMSRMGATPTPFKSTGDITAAGVTEANKEPRSQEESPVPQPRTASRVFLRPSPEDEAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSGVKKNIRKSREDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLFGPIADIAMERLTTELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGIKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQQQQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASRDQLRDGSPPPAFKPEPPKVRNQNREDSFNYSKSNLSAMAGSEIPGGSTKGCPPPIAVKPAFGRSILKPSTPVPMPESEEVGESTEEQEEAPKSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPQHMRPPEPQKAPSRLYQDTRGSYGSDPEEEEEYRQQLAAHSKRGYYSQPSRYRDTEL
Protein: Mannosylinositol phosphorylceramide synthase catalytic subunit (A0A1D8PIF7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MRKELKCIIWAHVGLIVYLLYLSFDLLSLLNDDIFSDALLDVEINPNPSTSLNKPAIIPKIIHQTYKTTDIPEIWKPGQQACINLHQDDYQYFLWTDESAREFINKEFNWFIDTWDNYKYPIQRADAIRYFALYYYGGIYIDLDDGCKRKLDPLLTVPAFVRKTAPTGISNDVMGSVPNHPFFLKVIQDLEKYQRNWLVPYITIMMSTGPLFLSIMWKQYKRWGVPEAGKVRILLPQNYKGTTSSYFAIVRGSSWHMGDANFIKSLGDHLVLAVIGGFLLGLLILFVEYLFYSWVISSQCKRLTSKLLSFTWAILMGVLRFFHLDKLLSKCDFWSRSTKYEEMLLPKDSNDLKNINNNNTSNNNTNGGDSNNNDKSDYNNNDNNNNNINNHTGKTRLSSIFNILGGKTKVKRRNRKDSNLPIEIDVLSKLLDDTVIIDASTTETPTNPVSPTPSPISPTINSRTSNNELLIPTNNNNNNNNNNNDNTNNVNNINNRTTCDDQSTLLPYSTRLSSSSSSSSSSPSSSTSSLPSHETIMKLNNDIV
Protein: ETS-related transcription factor Elf-5 (E74-like factor 5) (Q8VDK3)
Organism: Mus musculus (Mouse)
Function: Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
Interaction partners:
- Homeobox protein CDX-2
- Trans-acting T-cell-specific transcription factor GATA-3
- Transcriptional enhancer factor TEF-3
- Eomesodermin homolog
Sequence:
MLDSVTHSTFLPNASFCDPLMPWTDLFSNEDYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCSMTQEEFIEAAGICGEYLYFILQNIRSQGYSFFNDAEETKTGIKDYADSSCLKTSGIKSQDCHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEEKL
Protein: Zinc finger protein 521 (J3KTI4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHSS
Protein: Serotonin N-acetyltransferase (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) (Q9PVD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Acetylserotonin O-methyltransferase
- Acetylserotonin O-methyltransferase
- Aromatic-L-amino-acid decarboxylase
- Amine oxidase [flavin-containing]
- Indoleamine 2,3-dioxygenase 1.
- Amine oxidase.
- Serotonin N-acetyltransferase
- Period homolog 1b
- Orexin receptor type 2
- Period circadian protein homolog 2
Sequence:
MMAPQVVSSPFLKPFFLKTPISVSSPRRQRRHTLPASEFRNLTPQDAISVFEIEREAFISVSGECPLTLDEVLVFLGQCPELSMGWFEEGQLVAFIIGSGWDKEKLEQEAMSTHVPDSPTVHIHVLSVHRHCRQQGKGSILLWRYLQYLRCLPGLRRALLVCEEFLVPFYQKAGFKEKGPSAISVAALTFTEMEYQLGGLAYARRNSGC
Protein: Early growth response protein 1 (EGR-1) (Zinc finger protein Krox-24) (P26632)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity). Plays a role in regulating the expression of circadian clock genes (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P18146}. Cytoplasm {ECO:0000250|UniProtKB:P18146}.
Interaction partners:
- Mitogen-activated protein kinase
- Protein c-Fos
- Mitogen-activated protein kinase
- Transcription factor Jun
- FBJ murine osteosarcoma viral oncogene homolog B
- NGFI-A-binding protein 2
- Neuronal PAS domain-containing protein 4A
- Signal transducer and activator of transcription
- Cellular tumor antigen p53
- Activating transcription factor 3
Sequence:
MAAAKTEMLLPALQISDPLSFPHSPTDNYPKLEEMIMLNSAGTPFLNATAPEGAVFGSGEPGEQFDHLAGDTLSEISMEKPLSDQTYSTQRLPPISYTGRFTLEPATNCSNSLWAEPLFSLVSGLVGINPPPASIPSSTSQATHPSSSSTSSIPSSSSSSTSSASLSCSVHQSEPNPIYSAAPTYSSASPDIFPESGPNFSTTVGTSLQYSSSTYPSAKTCNPSFSVPMIPDYLFTQQQSEISLVPPDQKPIQTQAGQQPALTPLHTIKAFATQTGSQDLKSVYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVETCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACEICGRKFARSDERKRHTKIHMRQKDKKAEKGATAAVQSSVSNISISASSPVSSYPSPITSYPSPVSSFPSPVNSCYSSPVHTSYPSPSIATTYPSATSTFQTQVATSFPTSVASNIYSSPVTTPLPDMQSALSPRTADIC