wanglab/gogpt-training-data huggingface dataset:
Protein: Chorismate mutase (EC 5.4.99.5) (EqCMU) (A0A5B8NIM2)
Organism: Erysiphe quercicola (Hevea powdery mildew)
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate. May function both as an effector during plant infection and in the fungal tyrosine and phenylalanine biosynthesis pathways. During infection it channels chorismate into the phenylpropanoid pathway, thereby decreasing the synthesis of the plant immune signal salicylic acid (Probable). Within fungal cells, it acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan (Probable).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:33010586}. Secreted {ECO:0000305|PubMed:33010586}. Host cytoplasm {ECO:0000305|PubMed:33010586}. Note=Appears to be secreted despite an apparent lack of a secretory signal. {ECO:0000305|PubMed:33010586}.
Interaction partners:
Sequence:
MDAAVDLLDPSKALNLKHIRQQLIRMEDTITFQLIERVQFPLNRTVYEPGAVKIPNSNLSFLDWTLREREKTDSLIRRYQSPDEHPFFPDALLKPILQPLIYPKILHRNNINLNDKIKKYFTDQVLPSICHDFGREDRGEQAENYGSTVTADIQCLQTLSRRIHFGKWVAESKYIDDPQGFAKLIKAGDRQAIGKAITKPAVELQVLERIRLKSRTYSTDPCESDDPEPKINVDAVVAMYRDCVIPLTKEVEIDYLMQRLSD
Protein: Ribosomal large subunit pseudouridine synthase B (EC 5.4.99.22) (23S rRNA pseudouridine(2605) synthase) (rRNA pseudouridylate synthase B) (rRNA-uridine isomerase B) (P37765)
Organism: Escherichia coli (strain K12)
Function: Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA.
Interaction partners:
- Ribosomal large subunit pseudouridine synthase C synthase)
- Dual-specificity RNA pseudouridine synthase RluA
- Cytidylate kinase
- GTPase Der
- Ribosomal large subunit pseudouridine synthase D synthase)
- Dual-specificity RNA methyltransferase RlmN
- 5'-3' exoribonuclease Rnm
- Uncharacterized protein YciO
- Uncharacterized protein YibL
- ATP-dependent RNA helicase SrmB
Sequence:
MSEKLQKVLARAGHGSRREIESIIEAGRVSVDGKIAKLGDRVEVTPGLKIRIDGHLISVRESAEQICRVLAYYKPEGELCTRNDPEGRPTVFDRLPKLRGARWIAVGRLDVNTCGLLLFTTDGELANRLMHPSREVEREYAVRVFGQVDDAKLRDLSRGVQLEDGPAAFKTIKFSGGEGINQWYNVTLTEGRNREVRRLWEAVGVQVSRLIRVRYGDIPLPKGLPRGGWTELDLAQTNYLRELVELPPETSSKVAVEKDRRRMKANQIRRAVKRHSQVSGGRRSGGRNNNG
Protein: SH3 and cysteine-rich domain-containing protein (Src homology 3 and cysteine-rich domain-containing protein) (Q99469)
Organism: Homo sapiens (Human)
Function: Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P97306}. Cell membrane {ECO:0000250|UniProtKB:P97306}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97306}; Cytoplasmic side {ECO:0000250|UniProtKB:P97306}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P97306}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97306}; Cytoplasmic side {ECO:0000250|UniProtKB:P97306}.
Interaction partners:
- HLA class I histocompatibility antigen, alpha chain G
- E3 ubiquitin-protein ligase TRIM45
- Spartin
- F-BAR and double SH3 domains protein 2
- Killer cell immunoglobulin-like receptor 3DL3
- Killer cell immunoglobulin-like receptor 2DL1
- Killer cell immunoglobulin-like receptor 2DL4
- Sorbin and SH3 domain-containing protein 1
- Killer cell immunoglobulin-like receptor 3DL1
- Killer cell immunoglobulin-like receptor 3DL2
Sequence:
MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI
Protein: Protein-glutamine gamma-glutamyltransferase Z (Transglutaminase Z) (TG(Z)) (TGZ) (TGase Z) (EC 2.3.2.13) (Transglutaminase-7) (TGase-7) (Q96PF1)
Organism: Homo sapiens (Human)
Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Interaction partners:
Sequence:
MDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITFVAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLLESGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGGGTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVLKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLGTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVAGAP
Protein: General O-oligosaccharyltransferase (General O-OTase) (EC 2.4.-.-) (Q6FFS6)
Organism: Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Function: Catalyzes the O-glycosylation of multiple protein targets. Is responsible for general protein glycosylation within A.baylyi ADP1. Does not act as an O-antigen ligase.
Subcellular location: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Polysaccharide export protein
- Uncharacterized protein
- TonB C-terminal domain-containing protein
- TonB-dependent receptor plug domain-containing protein
- Multiple inositol polyphosphate phosphatase 1
- Uncharacterized protein
Sequence:
MAGSPRVYNSQHCGFSVAVMRFLLLLLTAVLISLAWLSPDHSYPWLTFASEMLSFAAFLSLLALFLNRPLELPRVQLLALPVVFIPMIQWGFGLVVDFSSALLSSAYLLGFWLTMLLGYNLSRSSADRERMFTLSSYLLFAVALLTSLIACIQWLNLESHVPGVMNLYSHRPYANFAQPNNMSTFLILGLLGCLYLAEKQKLKQYYIWPVAALIVFAITLSQSRTAWVFGLFFIIYWTYKSWRYPTHLKRYAVLLWAIGFFAVGLLFPRFTRLIQKLKEGNVVQTSSVVERASAGHERLGIWQQMLDAIHQKPWTGYGWNQTSIAELSSMSSNTIHVWFTSAHNVVLDLLVWNGWLLGGLITICILIWICWLNVHAKTTESIIACLMVSAVWIHTLLEYPLQYAYFLLPVGFLMGLIQAQTPDQTARSVPVSVIRSIWVIGIMLLALIWRDYNLYKVNSLRILKNQPANIEIWGSSKILVLTEFDQRLYWLKLSPVAPLTSTELDQIEKMVQNKATPYNLQKYAQLLLANHQFEKAQQQIAYLNRLHKKDYTLQDLQQANASAVESSK
Protein: Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) (P43321)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Also binds telomerase RNA and is required for its accumulation.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:7799953}. Nucleus {ECO:0000269|PubMed:7799953}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- LSM complex subunit LSM7
- 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component
- Pre-mRNA-splicing factor 38
- Pre-mRNA-splicing factor BUD31
- Protein NAM8
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22
- Small nuclear ribonucleoprotein F
- Pre-mRNA-splicing helicase BRR2
- LSM complex subunit LSM6
Sequence:
MTMNGIPVKLLNEAQGHIVSLELTTGATYRGKLVESEDSMNVQLRDVIATEPQGAVTHMDQIFVRGSQIKFIVVPDLLKNAPLFKKNSSRPMPPIRGPKRR
Protein: Aminoaldehyde dehydrogenase ALDH10A8, chloroplastic (EC 1.2.1.-) (4-trimethylammoniobutyraldehyde dehydrogenase ALDH10A8) (EC 1.2.1.47) (Aldehyde dehydrogenase family 10 member A8) (Aminobutyraldehyde dehydrogenase ALDH10A8) (EC 1.2.1.19) (Betaine aldehyde dehydrogenase ALDH10A8) (EC 1.2.1.8) (Gamma-guanidinobutyraldehyde dehydrogenase ALDH10A8) (EC 1.2.1.54) (Q9S795)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dehydrogenase that catalyzes the oxidation of several aminoaldehydes. Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively. Production of 4-aminobutinoate by ALDH10A8 may confer tolerance to salt stress. Catalyzes the oxidation of 4-(trimethylamino)butanal and 4-guanidinobutanal to 4-trimethylammoniobutanoate and 4-guanidinobutanoate, respectively. Involved in glycine betaine biosynthesis. Catalyzes with low efficiency the oxidation of betaine aldehyde to glycine betaine.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21053011, ECO:0000269|PubMed:27725774}. Plastid, chloroplast {ECO:0000269|PubMed:27725774}. Note=Localizes in small organelles that may be leucoplasts. {ECO:0000269|PubMed:21053011}.
Interaction partners:
- Choline monooxygenase, chloroplastic
- Aldehyde dehydrogenase family 7 member B4
- Aminoaldehyde dehydrogenase ALDH10A9, peroxisomal
- Delta-1-pyrroline-5-carboxylate synthase B
- Proline dehydrogenase 2, mitochondrial
- Ketose-bisphosphate aldolase class-II family protein
- Spermidine synthase 1
- Spermidine synthase 2
- Delta-1-pyrroline-5-carboxylate synthase A
- Proline dehydrogenase 1, mitochondrial
Sequence:
MAIPMPTRQLFIDGEWREPILKKRIPIVNPATEEVIGDIPAATTEDVDVAVNAARRALSRNKGKDWAKAPGAVRAKYLRAIAAKVNERKTDLAKLEALDCGKPLDEAVWDMDDVAGCFEFYADLAEGLDAKQKAPVSLPMESFKSYVLKQPLGVVGLITPWNYPLLMAVWKVAPSLAAGCTAILKPSELASVTCLELADICREVGLPPGVLNVLTGFGSEAGAPLASHPGVDKIAFTGSFATGSKVMTAAAQLVKPVSMELGGKSPLIVFDDVDLDKAAEWALFGCFWTNGQICSATSRLLVHESIASEFIEKLVKWSKNIKISDPMEEGCRLGPVVSKGQYEKILKFISTAKSEGATILHGGSRPEHLEKGFFIEPTIITDVTTSMQIWREEVFGPVLCVKTFASEDEAIELANDSHYGLGAAVISNDTERCDRISEAFEAGIVWINCSQPCFTQAPWGGVKRSGFGRELGEWGLDNYLSVKQVTLYTSNDPWGWYKSPN
Protein: SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein) (P60192)
Organism: Rattus norvegicus (Rat)
Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9Z266}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z266}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9Z266}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z266}. Lysosome membrane {ECO:0000250|UniProtKB:O95295}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:18167355}. Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. {ECO:0000250|UniProtKB:O95295}.
Interaction partners:
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Biogenesis of lysosome-related organelles complex-1 subunit 2
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Multifunctional fusion protein
- Dysbindin
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- BLOC-1 related complex subunit 8
- KxDL motif-containing protein 1
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- BLOC-1-related complex subunit 5
Sequence:
MAAAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGVYPPGSPSK
Protein: A-type potassium channel modulatory protein KCNIP2 (Kv channel-interacting protein 2) (KChIP2) (Potassium channel-interacting protein 2) (Q9JM59)
Organism: Rattus norvegicus (Rat)
Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart (By similarity). Required for normal protein levels of KCND2 in the heart ventricle (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11263977, ECO:0000269|PubMed:12006572, ECO:0000269|PubMed:16820361, ECO:0000269|PubMed:24793047}; Lipid-anchor {ECO:0000269|PubMed:12006572}. Note=Detected on lipid rafts. {ECO:0000269|PubMed:24793047}.
Interaction partners:
- A-type voltage-gated potassium channel KCND3
- Potassium voltage-gated channel subfamily A member 4
- Voltage-gated potassium channel KCNC1
- A-type voltage-gated potassium channel KCND1
- Potassium voltage-gated channel subfamily A member 5
- A-type potassium channel modulatory protein DPP6
- Inactive dipeptidyl peptidase 10
- Sodium channel protein type 5 subunit alpha
- Potassium voltage-gated channel subfamily B member 1
Sequence:
MRGQGRKESLSESRDLDGSYDQLTGHPPGPSKKALKQRFLKLLPCCGPQALPSVSETLAAPASLRPHRPRPLDPDSVEDEFELSTVCHRPEGLEQLQEQTKFTRRELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSNYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTIDDRLSWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVESFFQKMDRNKDGVVTIEEFIESCQQDENIMRSMQLFDNVI
Protein: Coronin-2B (Coronin-like protein C) (Clipin-C) (Protein FC96) (Q9UQ03)
Organism: Homo sapiens (Human)
Function: May play a role in the reorganization of neuronal actin structure.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Integrin alpha-11
- Transducin-like enhancer protein 3
Sequence:
MTVTKMSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSFLVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTTGVSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEISTEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRRSDSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFKAPIKEKKSVVVNGIDLLENVPPRTENELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLRNSPKNC
Protein: Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver-type fatty acid-binding protein) (L-FABP) (P07148)
Organism: Homo sapiens (Human)
Function: Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Fatty acid-binding protein, intestinal
- Peroxisome proliferator-activated receptor alpha
- Aspartate aminotransferase, mitochondrial
- Platelet glycoprotein 4
- Apolipoprotein C-III
- Fatty acid-binding protein, heart
- Fatty acid-binding protein, adipocyte
- Apolipoprotein B-100
- Apolipoprotein A-I
- Scavenger receptor class B member 1
Sequence:
MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQNEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNTMTLGDIVFKRISKRI
Protein: Response regulator ErdR (Q9HY22)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- Oxygen sensor histidine kinase NreB
- histidine kinase
- histidine kinase
- Probable transcriptional regulator
Sequence:
MASYEILIADDHPLFRSALHQALTLGLGPDVRLVEAASIAELEARLNEKADWDLVLLDLNMPGAYGFSGLVLLRGQYPQVPVVMISAQEEAAVVQRSREFGASGFIPKSSPLETLQQAVRAVLDGDTWWPPQDAAAEALSEEAKAASAGLASLTPQQFRVLTMVCEGLLNKQIAYDLNVSEATVKAHVTAIFRKLNVRTRTQAALLLQQMETVPASH
Protein: Protein YIP5 (YPT-interacting protein 5) (P53108)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Possible role in vesicle-mediated transport. May be involved in proper membrane localization of Rab GTPases.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein YIP4
- Protein transport protein YIP1
- Golgi apparatus membrane protein TVP23
- Golgi apparatus membrane protein TVP15
- Prenylated Rab acceptor 1
- Protein transport protein YIF1
Sequence:
MPSNNSSFLDIDDDLEGVDDFGNEPNPFDDATVPDSPNMNNSTAGKGSEFYNTTGSKAESAPLQGQMDPPAYDQVIGQNDNDGLGRNGLRPGLINYYSKYFQIDLTQFKKRLSAVLTFRNDHNSESNEDNTDLYGAVWITATVVMINFTMSRGLNFIISDVIEGVKTGEDIDRASQFKKLLHSIWLFYGYTFGVPFITMQVLNRDEHSERNRSFKSVPELISVYGYANLIWIPVCVILNILDMSKRLRTVQAIQWAIVALGWAQSSYFLNSQISSNNNTETQSNGKFSLSIIVVVALHTLFCLLFRFIIF
Protein: SUMO-activating enzyme subunit (Q9VSD9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAAAINGVFPPTLHELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHREHVGKSKARVARESALSFNPDAKITAYHDSVTSTDYGVNFFKKFDLVLNALDNRADRNHVNRMCLNADVPLIESGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAKHLFNQLFGESLEDEDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRINTRQWAKDCNYDAGKLFNKFFNEDITYLLRMSNLWKTRKAPVPVQWDTLLPEGSSGDQKDVAKQHHKVWSIEECAQVFANSLKELSANFLKLEGDDTLAWDKDDQPAMDFVAACANVRSHIFYIEPKSRFENKSMAGNIIPAIATTNAITAGISVMRAFKVLEAKWEQCQAVYARLRPNARNHFLVPDASLPGPNPNCHVCASDPAITLKIDTKRMRIKELRDEVLVKTLNMLNPDVTVQSNGSILISSEEGETECNDGKLLSELNIVDGVILKCDDFFQNYELSIIISHFDAERDENLFEVVADASQLKPKDEDQKEAVKDKEDEPKSAKKRSTNGEGDSKDDGPSTSKRSRPNEVVEEDDDDCLVIEEDEDQADVVVVATDKLSVQSPPKSGSKRKPCEVIEDEDITEILESSDDEPAGPTKCKRSRLDDSNPVAVISID
Protein: Protein NUCLEOLAR COMPLEX ASSOCIATED 4 (AtNoc4) (Protein EMBRYO DEFECTIVE 2762) (F4IMH3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required during embryogenesis. Involved in nucleolar processing of ribosomal RNA (rRNA) 40S and 90S ribosomal subunits and ribosome assembly; early in ribosome biogenesis, especially required during the maturation of 5.8S rRNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).
Subcellular location: Nucleus membrane {ECO:0000250|UniProtKB:Q9BVI4}; Multi-pass membrane protein {ECO:0000255}. Nucleus, nucleolus {ECO:0000269|PubMed:23382868}.
Interaction partners:
- Periodic tryptophan protein 2
- AT3g56990/F24I3_70
- U3 small nucleolar ribonucleoprotein protein IMP3
- Putative U3 small nucleolar ribonucleoprotein
- M phase phosphoprotein 10
- Nucleolar-like protein
- Ribosomal RNA-processing 7 protein
- KRR1 small subunit processome component
- Putative WD-repeat membrane protein
- U3 small nucleolar RNA-associated protein 18 homolog
Sequence:
MASILSKKQKKNEKYTLKELKSLGHDLLTSRSHINNLPLLLTFVSPESPPQFVVESLLSLQSFFTPLLSQLPPTSSSPSSTKTEDPEVVFKAWLRSKFDEFVKLLLDVLVSQQSEDSLRGIVLGTLMEFVKLLNAGRFHSSIYHRLLDAIIHSEVDIEIFLDILTSKYFKYIDVRYFTYISMEKFVKTLEASVSADRTVIENNEAESDSKESLELSVRKIYQVLSQIPPPEKQAEKSQHEMWSGSDESISEKPTDKKKKTEKGDSTLLSPATISKRMKLKFTKAWISFLRLPLPIDVYKEVLASIHLTVIPHLSNPTMLCDFLTKSYDIGGVVSVMALSSLFILMTQHGLEYPFFYEKLYALLVPSVFVAKHRAKFLQLLDACLKSSMLPAYLAASFTKKLSRLSLSIPPAGSLVITALIYNLLRRNPTINHLVQEIVENADEANTEAGEHNESQPKTIKKRKLGIDYFNNQESDPKKSGALKSSLWEIDTLRHHYCPPVSRFISSLETNLTIRSKTTEMKIEDFCSGSYATIFGDEIRRRVKQVPLAFYKTVPTSLFADSDFPGWTFTIPQEEGTC
Protein: Calmodulin (PfCaM) (P62203)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P24044}. Note=In trophozoites and schizonts, localizes throughout the cytoplasm. In merozoites, localizes to the apical complex. {ECO:0000250|UniProtKB:P24044}.
Interaction partners:
- Calmodulin, putative
- Myosin-A
Sequence:
MADKLTEEQISEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEIDTDGNGTIDFPEFLTLMARKLKDTDTEEELIEAFRVFDRDGDGYISADELRHVMTNLGEKLTNEEVDEMIREADIDGDGQINYEEFVKMMIAK
Protein: Rho guanine nucleotide exchange factor 3, isoform J (Rho guanine nucleotide exchange factor 3, isoform K) (E1JHV3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MITTTTASDPGSEAGDTSSGKYRFGPLIWRSSKERRKTKYNRRDKCNSGDSGIQIELEQDEQYSRATMAVSRQDEPRAFALTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNIGESDKAERKAPESLPTRSLSQPNGLESYGMGRPDLEDSDSDSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVEDILGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQNQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSETIARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRVVNVRDGKMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAKSTSRLCETLPKKSQSRDGISSAENSQIVTTTSTGSLGRRHFGNWFRKPKSANCTPSQSPTHKPSFDADATLTEARVAAMELAEAAAALVPTDSSSA
Protein: Transcription factor SOX-3 (cSox3) (P48433)
Organism: Gallus gallus (Chicken)
Function: Transcription factor that may function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MYSMLETEIKTPQPTRAARGEPARAATAKVGGAAAADGCRSDQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGADWKLLSDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSLPGNLWPPGSAGAAAVGVGQRIDTYAHMNGWTNGAYSLMQDQLGYGQHPGMNSPQLQQMHRYDMPGLQYSPMMSTAQTYMNAGLHLQHVPRPYGQQPSTAMSLGSMGSVVKSEPSSAPPAITSHSQRACLGELRDMISMYLGPGGDATHPSALQGSRLHSVHQHYQSAGTRVNGTVPLTHI
Protein: Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta) (Q9UI10)
Organism: Homo sapiens (Human)
Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09924}.
Interaction partners:
- Translation initiation factor eIF2B subunit gamma
- Translation initiation factor eIF2B subunit epsilon
- Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit beta
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 2 subunit 3
- Eukaryotic translation initiation factor 2 subunit 2
- Guanine nucleotide exchange factor MSS4
- Thymidine phosphorylase
- eIF-2-alpha kinase GCN2
Sequence:
MAAVAVAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQVGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ