wanglab/gogpt-training-data huggingface dataset:
Protein: Protein meg-1 (Maternal effect germ cell defective 1) (Q21126)
Organism: Caenorhabditis elegans
Function: P granule component, which acts redundantly with P granule component meg-2 to promote P granule segregation during embryogenesis, and germ cell proliferation and differentiation in larval stages. In its phosphorylated form, and together with meg-2, promotes the disassembly of zygotic P granules in the anterior cytoplasm of pre-gastrulation embryos. In its dephosphorylated form, and together with meg-2, promotes the assembly and accumulation of zygotic P granules in the posterior cytoplasm of pre-gastrulation embryos. May function with the nanos family members nos-2 and nos-3 to promote germ cell proliferation during larval development. Required for fertility.
Subcellular location: Cytoplasmic granule {ECO:0000269|PubMed:18202375}. Note=Localizes to P granules in embryogenesis (PubMed:18202375). Localization to P granules may depend on mes-1 (PubMed:18202375). {ECO:0000269|PubMed:18202375}.
Interaction partners:
- RNA-binding protein pos-1
- Uncharacterized protein
- Uncharacterized protein
- CCCH-type zinc finger protein oma-2
- PIP-1
- Paired zinc finger protein 1
- CCCH-type zinc finger protein oma-1
- J domain-containing protein
- F-box domain-containing protein
- M-phase inducer phosphatase cdc-25.3
Sequence:
MDNRGHFSSNGNFPPQGYHRREQSQEGMRIGNHHGPFSSGNMRSIGGSAQNQQQRHWTNMLNGSNNVENSWVCFSGNTSLADDPNVLSNFSALAQQRVNHFDTIVQERDNRNASFLNGSAVGNNLNTSFSVFGNLRGGDQDHRVLSDHTGIYTGLGSTGQNAVGTGIRLAADVANGNFLEQRAPTAMGHNQSYSALNQSLAPTLLDQYNQALLDQYNQSSQMAQGRGYPAPNIAYGLQNAGFPAPQIAHRPNTQNADPQAMNMNNRLRDHTFQMPHTNAQVPMSSLPGLFNLSMNHGSGNQQFQMNQSSSGPAPQLPNLSESFQMAQGSSQVTMSSRPAHSNTSMNHSSRNQYNHVDQRPSRPAPHLPTLTKEEEAFLETPDFEQFGRQLYNYLLPGILPNGAADTFSDAPKHQLLKLAKTLKPMLYDYWRKTMQMQNRGANINIIQWIIDFNAKFAALNSSVAKASNSSDVLNQTLPTAAEVSDVAREDASTSQPSKSRSMYIRPAASLDNTLETLDENLDSSQSHAGPVPAASTKPKTPSFEKMIRYSGIKKRSTMDMDNFVRMLDEKINFSPEPSTSSDIASSVKGYMSQSFLHQQDDEAPDCTKNVHSESDLKQAEPQESDKQSDKELPSNE
Protein: Cdc42 guanine nucleotide exchange factor 9 (A0A5F9ZI31)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK
Protein: poly(A)-specific ribonuclease (EC 3.1.13.4) (Q8MR41)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
GLTFMDDDGKTPPGYSTWQFNFKFNLSEDMYAQDSIDLLQNSGIQFKKHEEDGIDPIDFAELLMSSGIVLVENIKWLCFHSGYDFGYLLKLLTDQNLPPDESEFFDLLHIIFPNIFDIKYLMKSCKNLKGGLQEVADQLELRRVGPQHQAGSDALLTGMAFFKMREVQHTNDFHITPVAHDVLFRYLLEHTMNLKPTISCIHLLSRPAYNGGPAPDESAIISSGNGTGNTNSTEQFTSSAYMVTPPNTPGMAKSDAASLSNRHTSISNSFG
Protein: Homeobox protein engrailed-2a (Homeobox protein en-2a) (Zf-En-2) (P09015)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus.
Interaction partners:
- Paired box protein Pax-2a
- CDC42 small effector protein 1
- Fibroblast growth factor 8
- Early growth response protein 2b
- Hairy-related 5.
Sequence:
MDENEQSARDVEQRGASDESNSAIRPLLQAPGNLQLPHRITNFFIDNILRPDFGRKKEANITRYEDNHGARENHNPTGPSTGQVGSTVPAEEASTTHTSSGGKEAEIESEEPLKPRGENVDQCLGSESDSSQSNSNGQTGQGMLWPAWVYCTRYSDRPSSGPRSRKPKKKAASKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELGLNESQIKIWFQNKRAKIKKASGVKNGLAIHLMAQGLYNHSTTSKEDKSDSD
Protein: Cutinase 1 (EC 3.1.1.74) (Cutin hydrolase 1) (L1) (P52956)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P11373}.
Interaction partners:
- Carboxylesterase type B domain-containing protein
- Carboxylesterase type B domain-containing protein
- Carboxylesterase type B domain-containing protein
- Carboxylic ester hydrolase
- Carboxylic ester hydrolase
- Carboxylic ester hydrolase
- Carboxylesterase type B domain-containing protein
- Carboxylic ester hydrolase
- Carboxylesterase type B domain-containing protein
- Carboxylic ester hydrolase
Sequence:
MHLRNIVIALAATAVASPVDLQDRQLTGGDELRDGPCKPITFIFARASTEPGLLGISTGPAVCNRLKLARSGDVACQGVGPRYTADLPSNALPEGTSQAAIAEAQGLFEQAVSKCPDTQIVAGGYSQGTAVMNGAIKRLSADVQDKIKGVVLFGYTRNAQERGQIANFPKDKVKVYCAVGDLVCLGTLIVAPPHFSYLSDTGDASDFLLSQLG
Protein: Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2) (P32443)
Organism: Mus musculus (Mouse)
Function: Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation. Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (By similarity). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (By similarity). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P50222}. Nucleus speckle {ECO:0000250|UniProtKB:P50222}.
Interaction partners:
- Transcription factor 15
Sequence:
MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHQQQQHQALQSNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPADVEKRSGSKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSLANEDSRDSDHSSEHAHL
Protein: Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein (F4K2L8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLNSITLTRKPPLPFNSVGFSGNHSSSFGRRTITEGSSSKALSFGYKNVGSLKCGRSNWPGRSGTAFGHLVRVSAVPGGNSGGSGGLGGSGGGGGGSGGGGGDGSDGKGKKWSLLSWYQALLSNSPVLTKAVTAALLNLVGDLICQLTINKTSSLDKKRTLTFTFLGLGLVGPTLHFWYLYLSKVVTASGLSGAVIRLLLDQFVFAPIFVGVFLSAVVTLEGKPSNVIPKLQQEWTGAMIANWQLWIPFQFLNFRFVPQNYQVLASNVVALAWNVILSFKAHKEVVAK
Protein: Uncharacterized rhomboid protein P4H10.10, mitochondrial (EC 3.4.21.-) (Q9P7D8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MCISSSSLLCGINSLKYASNRVGILIPPFQTASSLNIFRPYVIFSRSHRSLSSVDVSSPSLPLREHLPLKNVYSQVPLLPVWSPIPKGPRRFLLPPKFHYRLSPPPGEFKSSPRVAIMVAVIVCLVNGVVFWHWDLARDEAIRLHDFKRFRFMMTHAQASLFNLYEGRWWTLVVSIFSHQNLAHLLVNCVAIYSFLSIVVYKFGVWKALSVYLGAGVFGNYVALQRMMNEENPFATLPNGPTKVWDLLFPKGPYPPISRPALYLGSNPEYGPIIRTATFVPQSWATGLLGASGAVYATAAIFACLFPYTEFFLFFVYPVKAGIFMPLDFIAEYVLCLLNYEKKFHVAFDAHVSGTFFGVVSSLFLLPAMWKRRSLYCVGIVKKRIWSNKAKA
Protein: Transcription factor FoxP2 (K4EPC4)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSTEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKGSEKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLNLQRQGLISIPPGQSALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHSIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESVCEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVHHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE
Protein: SOSS complex subunit C (SOSS-C) (SSB-interacting protein 1) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (Single-stranded DNA-binding protein-interacting protein 1) (X6R8P6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU369016}.
Interaction partners:
Sequence:
MQNQSSTNHPGASIALSRPSLNKDFRDHAEQQHIAAQQKAALQHAHAHSSGYFITQDSAFGNLILPVLPRLDPE
Protein: Cyclin-Q (CDK10-activating cyclin) (Cyclin-M) (Cyclin-related protein FAM58A) (Cyclin-related protein FAM58B) (Q8QZR8)
Organism: Mus musculus (Mouse)
Function: Activating cyclin for the cyclin-associated kinase CDK10.
Interaction partners:
- Cyclin-dependent kinase 9
Sequence:
MEAVRPDSCESGPAAPRAEERPAPEARVHFRVTRFIMEAGVKLGMQSIPIATACTIYHKFFCEINLDAYDLYLVAMSSIYLAGKVEEQHLRTRDIINVSHRYFNPGSEPLELDSRFWELRDSIVQCELLMLRVLRFQVSFQHPHKYLLHYLISLKNWLNRYSWQRTPISVTAWALLRDSYHGGLCLRFQAQHLAVAVLYLALQVYGVEVPAEGEAEKPWWQVFSDDLTKPIIDNIVSDLIQIYTMDTEIP
Protein: Musashi, isoform E (A0A0B4KHV4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLFENPAVAAKLPFPYNVPPPLQAAAAAAAAVPNLRSVSEMNATSLYAGNPMENAAAAAAAAAAGLIDPHHNRDLHQALVASIANNSVAAIGGGLTTAAVLKSAAQQSQQAVQQNQNAVVVTPGLEQPKQEPAQQAALALLKENVNASAGAGQNNGQAAMGGSNKSGSSGRSTPSLSGGSGSDPAPGKLFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSRGFGFITFQEPCTVEKVLKVPIHTLDGKKIDPKHATPKNRPRQANKTKKIFVGGVSQDTSAEEVKAYFSQFGPVEETVMLMDQQTKRHRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIMLGTLGVQLPTAPGQLIGARGAGVATMNPLAMLQNPTQLLQSPAAAAAAQQAALISQNPFQVQNAAAAASIANQAGFGKLLTTYPQTALHSVRYAPYSIPASAATANAALMQAHQAQSVAAAAHHHQQQQQQQHHHQQQTHNAHVAAAQQQQQSHHNAVSNPASQAHSAAAAAALAANAANGAGAAGAHSLAAAAQQAGLMAGNPLNAAAAAAAAAANPAAAYSNYALANVDMSSFQGVDWSTMYGMGMYV
Protein: DNA repair protein RAD4 (P14736)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA repair protein RAD2
- UV excision repair protein RAD23
- DNA repair protein RAD16
- DNA repair protein RAD14
- DNA repair protein RAD7
- General transcription and DNA repair factor IIH helicase subunit XPD/RAD3
- DNA repair protein RAD10
- General transcription and DNA repair factor IIH subunit TFB1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- DNA repair protein RAD1
Sequence:
MNEDLPKEYFELIRKALNEKEAEKAPLSRRRRVRRKNQPLPDAKKKFKTGLNELPRESVVTVNLDSSDDGVVTVPTDDSVEEIQSSEEDYDSEEFEDVTDGNEVAGVEDISVEIKPSSKRNSDARRTSRNVCSNEERKRRKYFHMLYLVCLMVHGFIRNEWINSKRLSRKLSNLVPEKVFELLHPQKDEELPLRSTRKLLDGLKKCMELWQKHWKITKKYDNVGLYMRTWKEIEMSANNKRKFKTLKRSDFLRAVSKGHGDPDISVQGFVAMLRACNVNARLIMSCQPPDFTNMKIDTSLNGNNAYKDMVKYPIFWCEVWDKFSKKWITVDPVNLKTIEQVRLHSKLAPKGVACCERNMLRYVIAYDRKYGCRDVTRRYAQWMNSKVRKRRITKDDFGEKWFRKVITALHHRKRTKIDDYEDQYFFQRDESEGIPDSVQDLKNHPYYVLEQDIKQTQIVKPGCKECGYLKVHGKVGKVLKVYAKRDIADLKSARQWYMNGRILKTGSRCKKVIKRTVGRPKGEAEEEDERLYSFEDTELYIPPLASASGEITKNTFGNIEVFAPTMIPGNCCLVENPVAIKAARFLGVEFAPAVTSFKFERGSTVKPVLSGIVVAKWLREAIETAIDGIEFIQEDDNRKEHLLGALESWNTLLLKLRIRSKLNSTYGKIAEEEPNVTKEQNIADNHDNTETFMGGGFLPGIANHEARPYSEPSEPEDSLDYVSVDKAEESATDDDVGEDYSDFMKELEMSEESD
Protein: Myosin, essential light chain (EMLC) (Myosin light chain alkali) (P09402)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Myosin regulatory light chain
- Myosin-2 heavy chain
- Serine/threonine-protein kinase pakB
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase qkgA
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco11
- Inositol 1,4,5-trisphosphate receptor-like protein A
- Serine/threonine-protein phosphatase 2B catalytic subunit
Sequence:
MSASADQIQECFSIFDKDNDGKVSVEDIGACLRSLGKSPTMADIEALKTEIGAKEFDINTLKSIYKKPNIKTPQEQQKEMLDAFKALDKEGHGTIQGAELRQLLTTLGDYLSTAEVDELFKEISVDSTTGAVSYASLVNTIVSGYPLGGF
Protein: Stonin-2 (A0A3B3IU55)
Organism: Homo sapiens (Human)
Subcellular location: Synapse, synaptosome {ECO:0000256|PIRNR:PIRNR037099}. Cytoplasm {ECO:0000256|PIRNR:PIRNR037099}.
Interaction partners:
Sequence:
MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQDDSSEKMGLISEAASPPGSPEQPPPDLASAISNWVQFEDDTPWASTSPPHQETAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQTSGQASGADSTDKRTEWQTGRQTAVSPVQACSEHTSTRTHRLDPSPPSPQPKRSQNPGEGPEGASAPNDNSSSLQEDEEVEMEAISWQASSPAMNGHPAPPVTSARFPSWVTFDDNEVSCPLPPVTSPLKPNTPPSASVIPDVPYNSMGSFKKRDRPKSTLMNFSKVQKLDISSLNRTPSVTEASPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSISSTTGKSQRDSLIVIYQDAISFDDSSKTQSHSDAVEKLKQLQIDDPDHFGSATLPDDDPVAWIELDAHPPGSARSQPRDGWPMMLRIPEKKNIMSSRHWGPIFVKLTDTGYLQLYYEQGLEKPFREFKLEICHEISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHTAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILVKGNEIVLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPLTQVPCENVMIRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKASVRSISVEDKTDVRKWVNYSAHYSYQTTETDNLPNPLYCSCLPHTDLKRGSKRVVKIRWNASLEVPLASSIRTMV
Protein: Claudin-12 (Q9ET43)
Organism: Mus musculus (Mouse)
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular location: Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P56749}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Claudin-3
- Claudin-5
- Claudin-2
- Tight junction protein 2
- Claudin-1
- Tight junction protein 1
- Claudin-4
- Occludin
- Large ribosomal subunit protein bL27m
- Mitochondrial assembly of ribosomal large subunit protein 1
Sequence:
MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTIYTGLWVKCARYDGSSDCLMYDRTWYLSVDQLDLRVLQFALPLSIVIAMGALLLCLIGMCNTAFNSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWAIFYNSHLNRKFEPVFTFDYAVFVTIASSGGLFMTALLLFVWYCACKSLSSPFWQPLYSHAPGMHTYSQPYSSRSRLSAIEIDIPVVSHST
Protein: Protein SCM4 (Suppressor of CDC4 mutation 4) (P32564)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MQVSPAIVKGIAVSSLGLYAGILTSSTVISITTPINVLTQHLKNVLCTLGCWSTVLGGLATGAFGLSYYLAAPGERPNYLLCGLGVAPLSAAYLYLVSLFNHKLAPKCTRDQNDLEKQKDEKLPQHHPEVKDGEAACPFSKMNNAKTLKPESERSVKCHSYMSLHMSIVTGITIFTFGKCILDGFKA
Protein: Transcription termination factor MTERF5, chloroplastic (Mitochondrial transcription termination factor 5) (mTERF5) (Protein MTERF DEFECTIVE IN ARABIDOPSIS 1) (F4JVI3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription termination factor required for processing and steady-state levels of plastid transcripts. Involved also in chloroplast transcriptional pausing, a general feature of chloroplast genes. Specifically and positively regulates the transcription of chloroplast psbEFLJ encoding for photosystem II (PSII) core subunits psbE, psbF, psbL and psbJ; causes the plastid-encoded RNA polymerase (PEP) complex to pause at psbEFLJ by binding to the +30 to +51 region of double-stranded DNA, and recruits additional pTAC6 to the transcriptionally paused region of psbEFLJ. May play a role in response to abiotic stresses.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:21464319, ECO:0000269|PubMed:31128276}.
Interaction partners:
- Transcription termination factor MTEF18, mitochondrial
- PLASTID TRANSCRIPTIONALLY ACTIVE protein 6, chloroplastic
- Holliday junction resolvase MOC1, chloroplastic
- DNA-directed RNA polymerase 3, chloroplastic
- DNA-directed RNA polymerase subunit alpha
- Mitochondrial transcription termination factor family protein
- Pentatricopeptide repeat-containing protein GUN1, chloroplastic
- Probable inactive purple acid phosphatase 1
- Photosystem II reaction center protein J
- Transcription termination factor family protein
Sequence:
MQSLSQLGPSEIFLVARREKPSTRAQLWFTGRLSFRQETNGIRLKNRVEFSPRPVPPNLIAAEKEEAKAVLTLFFKKQGLSNSLSSRLINKSDLFIDHLVSRLHSVHKARYLVGRELTTLEIRDSLIPYLEQLHEEHGDLLAELVVSFPDPPAEPRLVASSPVSVLPPRGDTDSAADTRKLRAVSRVSELDTEGALRPQTLYLLDLGLNLEQIKTITRKFAAFPYYSLDGKIKPVVEFLLDLGIPKSDIPTILCKRPQICGISLTDNLKPTMAFLETLGIDKNQWAKIISRFPAILTYSRQKLTSTVEFLSQTGLTEEQIGRILTRCPNIMSYSVEDKLRPTMEYFRSLNVDVAVLLHRCPQTFGLSIESNLKPVTEFFLEKGFGLDEIGIMISRYGALYTFSLKENVMPKWDYFQTMDYPKSELVKFPQFFGYSLQERIKPRYELVQRSGVRLLLNQVLSLSGIEFEKVVKKKMMKLVSNNVIAEQSSGGLL
Protein: Meiotically up-regulated gene 84 protein (O13904)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit gpi15
- Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit
- N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Sequence:
MTLTHHSTFIKGIEGSAEGEIEDVRQTTVFDPPFYGHPMLVPPSPSLTTMFRTRSTTPDEEGTAIAEIDQQDWDIMVKVPTYEYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIYIHVVLNAYNTEVLTKPFSSLECIVDQYALVGEEDGAAHGRVVDLRLCDVNKQQLEET
Protein: Norrin cystine knot growth factor NDP (D3ZEP2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Frizzled-4
- LDL receptor related protein 5
- Tetraspanin-12
Sequence:
MRNHVLAASISMLSLLAIMGDTDSKTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS
Protein: Cyclin-dependent kinase 20 (EC 2.7.11.22) (Cell cycle-related kinase) (Cell division protein kinase 20) (A8WIP6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Cyclin-H
- CDK-activating kinase assembly factor MAT1
- General transcription factor IIH subunit 3
- DNA-directed RNA polymerase subunit
- General transcription and DNA repair factor IIH helicase subunit XPD
- Transcription initiation factor IIE subunit beta
- General transcription factor IIH subunit
- General transcription factor IIH subunit 1
- General transcription factor IIE subunit 1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
Sequence:
MDQYSILGRIGEGAHGIVFKAKHIETGETVALKKVALRRLEDGIPNQALREIKALQEIEDNQYVVKLKDVFPHGTGFVLVFEYMLSDLSEVIRNSQRPLTASQVKSYMMMLLKGVAFCHENSIMHRDLKPANLLISSTGHLKIADFGLARLFSNEGDRLYSHQVATRWYRAPELLYGARKYDEGVDLWAVGCIFGELLNNSPLFPGENDIEQLCCVLRVLGTPNQKVWPEITELPDYNKITFKENPPIPLEEIVPDTSPQAVDLLKKFLVYPSKQRISARQALLHPYFFTDPLPAHHSELPIPQRGGKHSRQRMQPPHEFTVDRPLHESVVDPSLIQKHAMSCS
Protein: Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] (Q9UMD9)
Organism: Homo sapiens (Human)
Function: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.
Subcellular location: Cell junction, hemidesmosome. Membrane; Single-pass type II membrane protein. Note=Localized along the plasma membrane of the hemidesmosome.; SUBCELLULAR LOCATION: [120 kDa linear IgA disease antigen]: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Exclusively localized to anchoring filaments. Localized to the epidermal side of split skin.; SUBCELLULAR LOCATION: [97 kDa linear IgA disease antigen]: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Localized in the lamina lucida beneath the hemidesmosomes.
Interaction partners:
- Dystonin
- Plectin
- Integrin beta-4
- CD151 antigen
- Laminin subunit alpha-3
- Laminin subunit beta-3
- Integrin alpha-6
- Laminin subunit gamma-2
- Laminin subunit alpha-4
- Keratin, type I cytoskeletal 14
Sequence:
MDVTKKNKRDGTEVTERIVTETVTTRLTSLPPKGGTSNGYAKTASLGGGSRLEKQSLTHGSSGYINSTGSTRGHASTSSYRRAHSPASTLPNSPGSTFERKTHVTRHAYEGSSSGNSSPEYPRKEFASSSTRGRSQTRESEIRVRLQSASPSTRWTELDDVKRLLKGSRSASVSPTRNSSNTLPIPKKGTVETKIVTASSQSVSGTYDATILDANLPSHVWSSTLPAGSSMGTYHNNMTTQSSSLLNTNAYSAGSVFGVPNNMASCSPTLHPGLSTSSSVFGMQNNLAPSLTTLSHGTTTTSTAYGVKKNMPQSPAAVNTGVSTSAACTTSVQSDDLLHKDCKFLILEKDNTPAKKEMELLIMTKDSGKVFTASPASIAATSFSEDTLKKEKQAAYNADSGLKAEANGDLKTVSTKGKTTTADIHSYGSSGGGGSGGGGGVGGAGGGPWGPAPAWCPCGSCCSWWKWLLGLLLTWLLLLGLLFGLIALAEEVRKLKARVDELERIRRSILPYGDSMDRIEKDRLQGMAPAAGADLDKIGLHSDSQEELWMFVRKKLMMEQENGNLRGSPGPKGDMGSPGPKGDRGFPGTPGIPGPLGHPGPQGPKGQKGSVGDPGMEGPMGQRGREGPMGPRGEAGPPGSGEKGERGAAGEPGPHGPPGVPGSVGPKGSSGSPGPQGPPGPVGLQGLRGEVGLPGVKGDKGPMGPPGPKGDQGEKGPRGLTGEPGMRGLPGAVGEPGAKGAMGPAGPDGHQGPRGEQGLTGMPGIRGPPGPSGDPGKPGLTGPQGPQGLPGTPGRPGIKGEPGAPGKIVTSEGSSMLTVPGPPGPPGAMGPPGPPGAPGPAGPAGLPGHQEVLNLQGPPGPPGPRGPPGPSIPGPPGPRGPPGEGLPGPPGPPGSFLSNSETFLSGPPGPPGPPGPKGDQGPPGPRGHQGEQGLPGFSTSGSSSFGLNLQGPPGPPGPQGPKGDKGDPGVPGALGIPSGPSEGGSSSTMYVSGPPGPPGPPGPPGSISSSGQEIQQYISEYMQSDSIRSYLSGVQGPPGPPGPPGPVTTITGETFDYSELASHVVSYLRTSGYGVSLFSSSISSEDILAVLQRDDVRQYLRQYLMGPRGPPGPPGASGDGSLLSLDYAELSSRILSYMSSSGISIGLPGPPGPPGLPGTSYEELLSLLRGSEFRGIVGPPGPPGPPGIPGNVWSSISVEDLSSYLHTAGLSFIPGPPGPPGPPGPRGPPGVSGALATYAAENSDSFRSELISYLTSPDVRSFIVGPPGPPGPQGPPGDSRLLSTDASHSRGSSSSSHSSSVRRGSSYSSSMSTGGGGAGSLGAGGAFGEAAGDRGPYGTDIGPGGGYGAAAEGGMYAGNGGLLGADFAGDLDYNELAVRVSESMQRQGLLQGMAYTVQGPPGQPGPQGPPGISKVFSAYSNVTADLMDFFQTYGAIQGPPGQKGEMGTPGPKGDRGPAGPPGHPGPPGPRGHKGEKGDKGDQVYAGRRRRRSIAVKP
Protein: UDP-glucose:protein N-beta-glucosyltransferase (UDP-Glc:protein N-glucosyltransferase) (EC 2.4.1.-) (HMW1C-like protein) (N-glycosyltransferase) (NGT) (B3H2N2)
Organism: Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Function: Inverting glycosyltransferase that catalyzes the transfer of one glucose moiety from UDP-glucose to an asparagine residue in peptides and proteins containing the NX(S/T) motif, resulting in their modification with a beta-linked 1,N-glucose. Likely acts as a key component of a general protein glycosylation system. Also accepts UDP-galactose as a substrate donor, albeit with low efficiency. Cannot use UDP-GlcNAc or UDP-GalNAc as substrate donor.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:21852240}.
Interaction partners:
Sequence:
MENENKPNVANFEAAVAVKDYEKACSELLLILSQLDSNFGGIQEIEFEYPVQLQDLEQEKIVYFCTRMATAITTLFSDPVLEISDLGVQRFLVYQRWLALIFASSPFVNADHILQTYNREPNRKNSLEIHLDSSKSSLIKFCILYLPESNVNLNLDVMWNISPELCASLCFALQSPRFIGTSTAFNKRATILQWFPRHLDQLKNLNNIPSAISHDVYMHCSYDTSVNKHDVKRALNHVIRRHIESEYGWKDRYVAHIGYRNNKPVMVVLLEHFHSAHSIYRTHSTSMIAAREHFYLIGLGSPSVDQAGQEVFDEFHLVAGDNMKQKLEFIRSVCESNGAAIFYMPSIGMDMTTIFASNTRLAPIQAIALGHPATTHSDFIEYVIVEDDYVGSEACFSETLLRLPKDALPYVPSALAPEKVDYLLRENPEVVNIGIASTTMKLNPYFLEALKAIRDRAKVKVHFHFALGQSNGITHPYVERFIKSYLGDSATAHPHSPYHQYLRILHNCDMMVNPFPFGNTNGIIDMVTLGLVGVCKTGAEVHEHIDEGLFKRLGLPEWLIANTVDEYVERAVRLAENHQERLELRRYIIENNGLNTLFTGDPRPMGQVFLEKLNAFLKEN