wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized permease YjhF (P39357)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- PTS system fructose-like EIIB component 2
- Sensor histidine kinase YpdA
Sequence:
MPLIIVVAGIALLLLLTIKIKLNTFVSLIIVSIAVAIASGMDLSKVVTSVESGLGGTLGHIGLIFGFGVMLGRLLADAGGAQRIALTMLNYFGKNKLDWAVVCSAFIVGIALFFEVGLILLVPILFAIAREAKISPMFMCVPMLSGLLVAHGFLPPHPGPTVIAREYGADVGLVLIYGIIVGIPTFILCGPVLNKFCQRIIPDAFKKEGNIASLGATRRFSESEMPGFGISFLTAMLPVILMAVVTIIQMTHAKSAADSGLFYNVILFLGNSTIAMLISLLFAIYTMGLGRGKTIPDLMDSCGKAIAGIAGLLLIIGGGGAFKQVLIDSGVGQYISTLVSGMDINPILMAWGVAAFLRICLGSATVAAISTAGLVIPLLAVHPNTNLALITLATGAGSCICSHVNDASFWMIKDFFGLTTKETLLSWTLMSTLLSISGLIFILLASLVL
Protein: Nuclear pore complex interacting protein family member A2 (Nuclear pore complex interacting protein family member A3) (A0A0B4J2F6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFCCLGYEWLSGGCKTWHSAWVINTLADHRHRGTDFGGSPWLLIITVFLRSYKFAISLCTSYLCVSFLKTIFPSQNGHDGSTDVQQRARRSNRRRQEGIKIVLEDIFTLWRQVETKVRAKICKMKVTTKVNRHDKINGKRKTAKEHLRKLSMKEREHGEKERQVSEAEENGKLDMKEIHTYMEMFQRAQALRRRAEDYYRCKITPSARKPLCNRVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSIIDNSLSLKTPPECLLTPLPPSALPSADDNLKTPAECLLYPLPPSADDNLKTPPECLLTPLPPSAPPSADDNLKTPPKCVCSLPFHPQRMIISRN
Protein: Asparagine--tRNA ligase, chloroplastic/mitochondrial (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (AtNS1) (Protein OVULE ABORTION 8) (O48593)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:10824085}. Mitochondrion {ECO:0000269|PubMed:10824085}.
Interaction partners:
- Glutamyl-tRNA
- Isoleucine--tRNA ligase, chloroplastic/mitochondrial
- Glutamyl-tRNA
- Isoleucine--tRNA ligase, cytoplasmic
- Proline--tRNA ligase, cytoplasmic
- Glutamine--tRNA ligase, cytoplasmic
- Methionine--tRNA ligase, cytoplasmic
- Methionine--tRNA ligase, chloroplastic/mitochondrial
- Leucine--tRNA ligase, chloroplastic/mitochondrial
- Proline--tRNA ligase, chloroplastic/mitochondrial
Sequence:
MAATFLPATSLRLTQNSTLRFLSFFTISNPSYSLFRPLRRRVLPPFDAFPANSRRRCFCTAVSESLGSGDGNKVESYEKRFGSKVGEFRKKLRIAEVKGGADEGLSRVGQSLNIMGWVRTLRSQSSVTFIEINDGSCLSNLQCVMTSDAEGYDQVESGSILTGASVSVQGTIVASQGTKQKVELKVEKIIVVGECDSSYPIQKKRVSREFLRTKAHLRPRTNTFGAVARVRNTLAYATHKFFQESGFVWVASPIITASDCEGAGEQFCVTTLIPSSHENTDTSIDAIPKTKGGLIDWSQDFFGKPAFLTVSGQLNGETYATALSDVYTFGPTFRAENSNTSRHLAEFWMIEPELAFADLDDDMACATAYLQYVVKYVLDNCKEDMEFFDTWIEKGIIRRLSDVAEKEFLQLGYTDAIEILLKANKKFDFPVKWGLDLQSEHERYITEEAFGGRPVIIRDYPKEIKAFYMRENDDGKTVAAMDMLVPRIGELIGGSQREERLEVLEARLDELKLNKESYWWYLDLRRYGSVPHAGFGLGFERLVQFVTGIDNIRDVIPFPRTPASAEF
Protein: Uncharacterized protein C30D11.14c (Q09911)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Pre-mRNA-processing protein prp40
- Uncharacterized protein C18H10.07
- Pre-mRNA-splicing factor cwf15
- Pre-mRNA-splicing factor srp1
- U1 small nuclear ribonucleoprotein usp102
- Beta-catenin-like protein 1 homolog
Sequence:
MSDSRQNSQREDNYSRDRRSRFTEDSYSRRDSQRSGNEAPRESRYYRKEEHLQERSRSRSPARDSRWKSSSSGFAPAHPPIEEPTNNGAEAAAAAARRIAESLQSTKATSSRTSYDHSEGITSTTSASPPSAPAPPLPPSSEGPAVDIPPSMADITSKVIEGDGVFMQDVEINNVRNRYILVRASTLSEIENKSGVQLFSKGRYYPNKALATDKDPPLYLHIVSHNRKDLTVALQEIESWINKDMGPLIDERRFRRREDNERNNSNSPRNFSTHGNGNGENGQPRRKWLEEKVYINLTPSRGFHLRQAIVGPQGAYVKHIQQETRTRVQIKGQGSAFIEPSTNRESDEPIHLCIMSHDPNAIQRAKVLCEDLIASVHQQYKAWKSQPKDRDQNQGNRAYNPPNRNQAFSARDSRQEKTQPTNASPAPLVTPSLPVPSIPAVPGMEAMAMPPGVTSSIAVPTTSSMPLQGMPTMFGAPGVSAPGTEAPGTGTPGLTTPGVDPYAAYGGYNAYVQYYQQQIYAQMHGVSGDQSHPQ
Protein: Toxin YkfI (P77692)
Organism: Escherichia coli (strain K12)
Function: Toxic component of a type IV toxin-antitoxin (TA) system. Acts as a toxin inhibitor that blocks cell division and cell elongation via FtsZ and possibly also MreB (although no interaction with MreB has been proven). Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation. These effects are overcome by concomitant expression of cognate antitoxin YafW, which leads to toxin loss by an unknown mechanism. Overexpression leads to formation of lemon-shaped cells and cell lysis; inactivated by overexpression of cognate antitoxin YafW but not when the 2 genes are coexpressed from the same plasmid. Also neutralized by overexpression of non-cognate antitoxins YfjZ and CbeA. Co-overexpression of toxin YkfI and antitoxin YafW leads to formation of elongated cells.
Interaction partners:
- Antitoxin YafW
- UPF0758 protein YkfG
- Uncharacterized protein YkfH
- Uncharacterized protein YafX
- Antitoxin YfjZ
- UPF0401 protein YkfF
- Cytoskeleton bundling-enhancing antitoxin CbeA
Sequence:
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGFSWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Protein: Probable glutathione S-transferase 5 (EC 2.5.1.18) (GST class-sigma) (Q09596)
Organism: Caenorhabditis elegans
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection.
Interaction partners:
- glutathione transferase
- Glutathione S-transferase P 10
- Glutathione S-transferase omega
- Glutathione transferase omega-1
- Glutathione reductase, mitochondrial
- Thioredoxin domain-containing protein
- Probable glutathione S-transferase 6
- glutathione transferase
- Glutathione peroxidase 1
- Glutathione peroxidase 2
Sequence:
MVSYKLTYFNGRGAGEVSRQIFAYAGQQYEDNRVTQEQWPALKETCAAPFGQLPFLEVDGKKLAQSHAIARFLAREFKLNGKTAWEEAQVNSLADQYKDYSSEARPYFYAVMGFGPGDVETLKKDIFLPAFEKFYGFLVNFLKASGSGFLVGDSLTWIDLAIAQHSADLIAKGGDFSKFPELKAHAEKIQAIPQIKKWIETRPVTPF
Protein: RNA binding motif protein 7 (G3V1T9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH
Protein: Transcriptional regulator SlyA (P0A8W2)
Organism: Escherichia coli (strain K12)
Function: Transcription regulator that can specifically activate or repress expression of target genes. Activates expression of genes such as molecular chaperones (groL, groS, dnaK, grpE, and cbpA), proteins involved in acid resistance (hdeA, hdeB, and gadA), the starvation lipoprotein slp, virulence protein hlyE/clyA. Represses expression of genes involved in the histidine biosynthetic pathway such as hisA, hisB, hisD, hisF and hisG. Required for the activation of virulence genes.
Interaction partners:
- Multiple antibiotic resistance protein MarR
- Hemolysin E, chromosomal
- Transcriptional regulatory protein PhoP
- Glutaredoxin 4
- Uncharacterized protein YdhI
- Sensor protein PhoQ
- DNA-binding dual transcriptional regulator OmpR
Sequence:
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLITLIAKLEHNIIELQAKG
Protein: Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin) (P25874)
Organism: Homo sapiens (Human)
Function: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P12242}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Lipid transferase CIDEA
- Histone-lysine N-methyltransferase PRDM16
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Beta-3 adrenergic receptor
- Peroxisome proliferator-activated receptor gamma
- Peroxisome proliferator-activated receptor alpha
- Leptin
- Insulin
- Type II iodothyronine deiodinase
- Adiponectin
Sequence:
MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQTMDCAT
Protein: Socs1 protein (Suppressor of cytokine signaling 1) (Suppressor of cytokine signalling) (Suppressor of cytokine-signaling 1a) (Q6DEF9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Tyrosine-protein kinase.
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase receptor.
- Tyrosine-protein kinase receptor
- Elongin-C
- Elongin-C
- Cullin-5
- Elongin-B
- Uncharacterized protein.
- Signal transducer and activator of transcription.
Sequence:
MVAHSSVEGNQGIEDRQVSTEASSDVFQSQRSRPRQSTVAFQTHFKPFNYARDFKIISNTTSMLEESGFYWGPMTVEEAHLKLKKESVGTFLIRDSRQSDVFFTLSYKAQNGPVSIRINFKNSKFSLTGSKESFDSLFKLLEHYISSPKKGLIRPCRKEPVQSLQQLCRRQIMERCDGKDIDCIPVQPILKDFLHAFPHPL
Protein: Large ribosomal subunit protein uL15m (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15) (Q9CPR5)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9P015}.
Interaction partners:
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein uL29m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein mS29
Sequence:
MAGTARGCGTSLDLLRSLPRVSLANLKPSPNSRKRERRPRDRRRGRKCGRGHKGERQRGTRPRLGFEGGQTPFYIRIPKYGFNEGHSFRHQYQPLSLRRLQYLIDLGRVDPTQPIDLTQLVNGRGVTIQPLKRDYGVQLVEEGADTFQAKINIEVQLASELAIAAIEKNGGVVTTAFYDPRSLEILCKPIPFFLRGQPIPKRMLPPESLVPYYTDAKNRGYLADPAKFPEARLELAMKFGYVLPDITKDELFRMLSARKDPRQIFFGLAPGWVVNMADKKILKPTDENLLKYYSS
Protein: Melibiose permease (Melibiose carrier) (Melibiose transporter) (Melibiose/cation symporter) (Na+ (Li+)/melibiose symporter) (Thiomethylgalactoside permease II) (P02921)
Organism: Escherichia coli (strain K12)
Function: Mediates the transport of melibiose and other galactosides by a symport mechanism. Can use sodium, lithium and protons as coupling cations, depending on the sugar substrate and the cationic environment. Alpha-galactosides (melibiose, raffinose, p-nitrophenyl-alpha-galactoside or methyl-alpha-galactoside) are cotransported with either Na(+) or H(+), whereas beta-galactosides (lactose, L-arabinose-beta-D-galactoside, D-fructose-beta-D-galactoside, methyl-beta-galactoside or p-nitrophenyl-beta-galactoside) are cotransported with Na(+) or Li(+) but not H(+). The monosaccharide D-galactose can use either Na(+) or H(+) for cotransport whereas D-fucose, L-arabinose and D-galactosamine can use only Na(+).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:1730719, ECO:0000269|PubMed:7703254, ECO:0000269|PubMed:8672452}; Multi-pass membrane protein {ECO:0000269|PubMed:1730719, ECO:0000269|PubMed:8672452}.
Interaction partners:
- Alpha-galactosidase
- PTS system glucose-specific EIIA component
- Lactose permease
- Melibiose operon regulatory protein
Sequence:
MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNATRSRWGKFKPWILIGTLANSVILFLLFSAHLFEGTTQIVFVCVTYILWGMTYTIMDIPFWSLVPTITLDKREREQLVPYPRFFASLAGFVTAGVTLPFVNYVGGGDRGFGFQMFTLVLIAFFIVSTIITLRNVHEVFSSDNQPSAEGSHLTLKAIVALIYKNDQLSCLLGMALAYNVASNIITGFAIYYFSYVIGDADLFPYYLSYAGAANLVTLVFFPRLVKSLSRRILWAGASILPVLSCGVLLLMALMSYHNVVLIVIAGILLNVGTALFWVLQVIMVADIVDYGEYKLHVRCESIAYSVQTMVVKGGSAFAAFFIAVVLGMIGYVPNVEQSTQALLGMQFIMIALPTLFFMVTLILYFRFYRLNGDTLRRIQIHLLDKYRKVPPEPVHADIPVGAVSDVKA
Protein: Leucine-rich repeat receptor-like protein kinase PEPR1 (EC 2.7.11.1) (Elicitor peptide 1 receptor 1) (PEP1 receptor 1) (Q9SSL9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a receptor for PEP defense peptides. Unlike typical immune receptors, senses an endogenous elicitor that potentiates pathogen-associated molecular pattern (PAMP)-inducible plant responses. Involved in PAMP-triggered immunity (PTI) signaling. Interacts with and phosphorylates the kinase BIK1, a central rate-limiting kinase in PTI signaling.
Subcellular location: Cell membrane {ECO:0000305|PubMed:17644812}; Single-pass type I membrane protein {ECO:0000305|PubMed:17644812}.
Interaction partners:
- Precursor of elicitor peptide 1
- Serine/threonine-protein kinase BIK1
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Elicitor peptide 3
- Elicitor peptide 2
- Elongation factor Tu, chloroplastic
- Elicitor peptide 7
- LysM domain-containing GPI-anchored protein 1
- LysM domain-containing GPI-anchored protein 3
- Elongation factor Tu
Sequence:
MKNLGGLFKILLLFFCLFLSTHIISVSCLNSDGLTLLSLLKHLDRVPPQVTSTWKINASEATPCNWFGITCDDSKNVASLNFTRSRVSGQLGPEIGELKSLQILDLSTNNFSGTIPSTLGNCTKLATLDLSENGFSDKIPDTLDSLKRLEVLYLYINFLTGELPESLFRIPKLQVLYLDYNNLTGPIPQSIGDAKELVELSMYANQFSGNIPESIGNSSSLQILYLHRNKLVGSLPESLNLLGNLTTLFVGNNSLQGPVRFGSPNCKNLLTLDLSYNEFEGGVPPALGNCSSLDALVIVSGNLSGTIPSSLGMLKNLTILNLSENRLSGSIPAELGNCSSLNLLKLNDNQLVGGIPSALGKLRKLESLELFENRFSGEIPIEIWKSQSLTQLLVYQNNLTGELPVEMTEMKKLKIATLFNNSFYGAIPPGLGVNSSLEEVDFIGNKLTGEIPPNLCHGRKLRILNLGSNLLHGTIPASIGHCKTIRRFILRENNLSGLLPEFSQDHSLSFLDFNSNNFEGPIPGSLGSCKNLSSINLSRNRFTGQIPPQLGNLQNLGYMNLSRNLLEGSLPAQLSNCVSLERFDVGFNSLNGSVPSNFSNWKGLTTLVLSENRFSGGIPQFLPELKKLSTLQIARNAFGGEIPSSIGLIEDLIYDLDLSGNGLTGEIPAKLGDLIKLTRLNISNNNLTGSLSVLKGLTSLLHVDVSNNQFTGPIPDNLEGQLLSEPSSFSGNPNLCIPHSFSASNNSRSALKYCKDQSKSRKSGLSTWQIVLIAVLSSLLVLVVVLALVFICLRRRKGRPEKDAYVFTQEEGPSLLLNKVLAATDNLNEKYTIGRGAHGIVYRASLGSGKVYAVKRLVFASHIRANQSMMREIDTIGKVRHRNLIKLEGFWLRKDDGLMLYRYMPKGSLYDVLHGVSPKENVLDWSARYNVALGVAHGLAYLHYDCHPPIVHRDIKPENILMDSDLEPHIGDFGLARLLDDSTVSTATVTGTTGYIAPENAFKTVRGRESDVYSYGVVLLELVTRKRAVDKSFPESTDIVSWVRSALSSSNNNVEDMVTTIVDPILVDELLDSSLREQVMQVTELALSCTQQDPAMRPTMRDAVKLLEDVKHLARSCSSDSVR
Protein: Rhodopsin (A4FUN8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}.
Interaction partners:
- S-arrestin
- Cone transducin alpha subunit, alpha transducing activity polypeptide 2) subunit alpha-2)
- Guanine nucleotide-binding protein
- G protein-coupled receptor kinase
- Rhodopsin kinase grk7a
- Rhodopsin kinase grk7-b
- G protein-coupled receptor kinase
- Recoverin
- Recoverin a
- Recoverin b
Sequence:
MNGTEGPDFYVPMSNESGVVRSPYEYPQYYLASPFAFYCMAAYMLFLIVTCVPVNGLTLYVTIENKKLRTPLNYILLNLAVADLFMVFGGFTTTFYTSMHGYFVLGRAGCNLEGLFATVGGEIALWSLVVLAVERWVVVCKPFTKFRFSQLHATLGVAFSWSMACSCAIPPLLGWSRYIPEGLQCSCGVDYYTPNPETENESFVIYMFVVHFSIPLTIISFCYGRLLCTVKVAAAQQQESETTQRAEREVTRMVILMVIAFLICWLPYASVAWYIFTHQGSQFGPVFMTVPAFFAKSSALYNPLIYVFMNKQFRHSMMMTVCCGKDPFQDEEEGSSSSKSKTETSSVSSSSASSA
Protein: ABC subunit of A-band LPS efflux transporter (G3XD58)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Transport permease protein
- Alginate biosynthesis protein AlgA
- Glycosyltransferase WbpX
- Glycosyltransferase WbpY
- Transport permease protein
- D-rhamnosyltransferase WbpZ
- GDP-6-deoxy-D-mannose reductase
- GDP-mannose 4,6-dehydratase
- Probable ATP-binding component of ABC transporter
- O-antigen translocase
Sequence:
MGQIRVSGLGKAYKQYPNRWSRLFEWLVPFSPPRHHLHWILREVEFTIEPGEAVGIVGVNGAGKSTLLKMIAGTTQPTCGEIRVAGRVAALLELGMGFHPDFTGRQNVFMAGQLLGMQVEEIQALMPDIEAFAEIGEAIEQPVRTYSSGMQMRLAFSVATARRPDILIVDEALSVGDAYFQHKSFERIRSFRKAGTTLLIVSHDRSAIQSICDSAILLEQGRMAMRGRPEEVMDYYNALLAEREGQTVRQEMLADGQVRTISGTGEAAILDVRMVDQRQRALEVVEVGQAVTLEVEVEVRQDIERLILGFMIKDRLGQPMYGINTHRLDKALTDLKAGERITYRFAFDMRLGKGHYSVALSLSRLDSHLDRNFEWRDYGLVFHVINNRQEDFVGCSWLGAETHISRSGEAALDPTSAESTP
Protein: Ankyrin repeat family protein (Q8VZ34)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquitin-conjugating enzyme/RWD-like protein
- Protein ELC-like
- Protein ELC
- Ubiquitin-ribosomal protein eS31x fusion protein
- Ubiquitin-ribosomal protein eS31y fusion protein
- Ubiquitin-ribosomal protein eS31z fusion protein
- Ubiquitin carboxyl-terminal hydrolase 27
- Clathrin heavy chain 1
- Clathrin heavy chain 2
- Vacuolar protein sorting-associated protein 36
Sequence:
MLFSNKVNSLTEQVSRLDIDDNDMGLGGSETMECKCGMPLCICVAPPKSTDKPNPPATIAPVVLPQLKSEASAKSKGSTSSSNARSALNAGLDTPQRDYEASGEGLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPLDCAPATLQYKMREKMKST
Protein: Protein Wnt-16 (Q9QYS1)
Organism: Mus musculus (Mouse)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Protein-serine O-palmitoleoyltransferase porcupine
- Wnt inhibitory factor 1
- Palmitoleoyl-protein carboxylesterase NOTUM
- Frizzled-6
- Low-density lipoprotein receptor-related protein 5
- Frizzled-4
- Glypican-3
- Frizzled-1
- Secreted frizzled-related protein 1
- Frizzled-8
Sequence:
MDRAALLALPSLCALWAAVLSLLPCGTQGNWMWLGIASFGVPEKLGCADLPLNSRQKELCKRKPYLLPSIREGARLGIQECRSQFRHERWNCMVATTTSTQLATAPLFGYELSSGTKETAFIYAIMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSPSEGWHWGGCSDDVQYGMWFSRKFLDLPIRNTTGKESRVLLAMNLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHFLKDKYENSIQISDKTKRKMRRREKDQRQTPILKDDLLYVHKSPNYCVENKKLGIPGTQGRECNRTSGGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK
Protein: Nuclear receptor coactivator (D4A3Q3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR038181}.
Interaction partners:
- Estrogen receptor
- Histone lysine acetyltransferase CREBBP
- Estrogen receptor beta
- Nuclear receptor coactivator 2
- Retinoic acid receptor RXR-alpha
- Peroxisome proliferator-activated receptor gamma
- Progesterone receptor
- Nuclear receptor coactivator 3
- Peroxisome proliferator-activated receptor alpha
- Estrogen-related receptor gamma
Sequence:
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLGTENQEACQRYEVMQCFTVSQPKSIQEDGEGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRINPSVNPGISPAHGVTRSSTLPPSNNNMVSARANRQQSTDLNSGSSHSNSSSSQGSFGCSPGNQIVASVALSQGQAGSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQANSGLATRARMSNNSFPPNIPTLSSPVGITSGACSNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMSSQNSPSRLSMQPAKAESKDNKEIASILNEMIQSDNSANEGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPEKKDSASASTAMSVSGQAQGSASIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPAPVTKPAPEEVKLESQSQFSADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVPGVNIKSEILPASLQPTPARSAPRLNRLPELELEAIDNQFGQPGAGDQIPWANNTVTAINQSKPEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLMMEDRPTLYPQPYSSPSPTAGLSGPFQGMVRQKPSLGTMPVQVTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAANAPVGMNMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQIIQQQRAMLMRHQSFGNNIPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLATRSSMVNRGMAGNMGGQFGTGISPQMQQNVFQYPGSGLVPQAEANFAPSLSPGSSMVPMPIPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNNMSITVSMAGGNANVQNMNPMMGQMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDLLKTEADGNQDKKTEEFFSVQVQQLQVFADVQCTVNLKGASKPTLVLAVLLQEKAIRTNADEEHGLKTSRKKPFPQVLPSASHRPWYKQLHKNSIYSETTGL
Protein: Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein) (Q8BNQ3)
Organism: Mus musculus (Mouse)
Function: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polarization.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:31173907}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with MTOR in lysosome after amino acid stimulation. {ECO:0000250|UniProtKB:O60478}.
Interaction partners:
Sequence:
MEAPPWEPVRNDSLPPTLSPAVPPYVKLGLTAVYTVFYALLFVFIYAQLWLVLRYRHKRLSYQSVFLFLCLFWASLRTVLFSFYFRDFVAANSFSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYLASLFISLVFLLVNLTCAVLVKTGDWDRKVIVSVRVAINDTLFVLCAISLSICLYKISKMSLANIYLESKGSSVCQVTAIGVTVILLYTSRACYNLFILSFSQIKNVHSFDYDWYNVSDQADLKSQLGDAGYVVFGVVLFVWELLPTTLVVYFFRVRNPTKDLTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNIAPQGLQGSFAPDYCDWGQQNNSFLAQAGTLHQDSTLDPDKASQG
Protein: Protein LppM (Putative lipoprotein LppM) (O53505)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: A putative lipoprotein that seems to be specialized for the initial steps of macrophage infection. A non-acylated fragment (residues 26-185) binds phosphatidyl-myo-inositol mannosides (PIMs). Limits, in a TLR2-dependent fashion, bacterial uptake by host (mouse); this effect may be mediated by nonacylated fragment 26-185. Plays a TLR2-dependent role in host phagosome maturation arrest. Plays a TLR2-independent role in chemokine production during the first 24 hours of mouse infection.
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Secreted, cell wall {ECO:0000269|PubMed:27568926}. Secreted {ECO:0000269|PubMed:27568926}. Note=Mature form (about 28 kDa) is associated with the cell wall and membrane fraction, secreted form is seen after 1 week axenic culture in Sauton's medium without detergent, this form is about 20 kDa (PubMed:27568926). May not be acylated, cell wall association is unchanged by mutation of the putatively acylated residue, and the mutant's migration does not change (PubMed:27568926). {ECO:0000269|PubMed:27568926}.
Interaction partners:
- Conserved protein
- ATP synthase subunit a
- Putative secreted protein Rv0236A
- GCN5-like protein acetyltransferase Rv2170
- Probable conserved transmembrane protein
- Conserved protein
- Uncharacterized protein Rv0010c
- Conserved protein
- Conserved protein
- Probable conserved transmembrane protein
Sequence:
MARTRRRGMLAIAMLLMLVPLATGCLRVRASITISPDDLVSGEIIAAAKPKNSKDTGPALDGDVPFSQKVAVSNYDSDGYVGSQAVFSDLTFAELPQLANMNSDAAGVNLSLRRNGNIVILEGRADLTSVSDPDADVELTVAFPAAVTSTNGDRIEPEVVQWKLKPGVVSTMSAQARYTDPNTRSFTGAGIWLGIAAFAAAGVVAVLAWIDRDRSPRLTASGDPPTS
Protein: Cytochrome P450 CYP2J9 (Cytochrome P450, family 2, subfamily j, polypeptide 9) (Q924D1)
Organism: Mus musculus (Mouse)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}. Microsome membrane {ECO:0000256|ARBA:ARBA00004524}.
Interaction partners:
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Cytochrome P450 1A2
- Polyunsaturated fatty acid 5-lipoxygenase
- Cytochrome P450 2E1
- Prostaglandin G/H synthase 1
- Prostaglandin G/H synthase 2
- Cytochrome P450 2U1
- Polyunsaturated fatty acid lipoxygenase ALOX8
- Polyunsaturated fatty acid lipoxygenase ALOX12
- Arachidonate 12-lipoxygenase, 12R-type
Sequence:
MLAAAGSLVAAIWAALHLRILLLSAVTFLFLADFLKNRRPKNYPPGPMRLPFVGCLFHLDPKQPHLSLQQFVKKYGNVLSLDFANIPSVVITGMPLIKEIFTQMEHNFMNRPVTLLRKHLFNKNGLIFSSDQTWKEQRRFALMTLRNFGLGKRSLEERIQEEAHYLVEAIRDEGGQPFDPHFNISNAVSNIICSITFGERFDYHDSQFQEMLRLLDEAMCLESSMMCQLYNIFPRILQYLPGSHQTLFRNWRKLQLFVSDIVNNHRRDWDPDEPRDFIDAFLTEMTKYPDKTTTSFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQEKMQAEIDRVIGQARQPNLADRDSMPYTNAVIHEVQRMGNIIPFNVPREVAVDTQLAGFNLPKGIMVLSNLTALHRDPSEWTTPDTFNPEHFLENGQFKKRESFLPFSMGKRACLGEQLARSELFIFITTLFQKFTFKPPVNEKLSLQFRMAATVSPVSHRLCAIPRL