wanglab/gogpt-training-data huggingface dataset:
Protein: Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) (P41562)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase. Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (By similarity). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10521434, ECO:0000269|PubMed:8083215}. Peroxisome {ECO:0000269|PubMed:10521434}.
Interaction partners:
- Cytoplasmic aconitate hydratase
- Aconitate hydratase, mitochondrial
- 2-oxoglutarate dehydrogenase complex component E1
- Isocitrate dehydrogenase subunit alpha, mitochondrial
- Citrate synthase, mitochondrial
- Isocitrate dehydrogenase subunit beta, mitochondrial
- Isocitrate dehydrogenase subunit gamma 1, mitochondrial
- Probable isocitrate dehydrogenase gamma 2, mitochondrial
- 2-oxoglutarate dehydrogenase-like, mitochondrial
- Glutamate dehydrogenase 1, mitochondrial
Sequence:
MSRKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHDFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALEEVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL
Protein: Nuclear receptor coactivator (A0A8I6APA0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR038181}.
Interaction partners:
Sequence:
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRINPSVNPGISPAHGVTRSSTLPPSNNNMVSARANRQQSTDLNSGSSHSNSSSSQGSFGCSPGNQIVASVALSQGQAGSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQANSGLATRARMSNNSFPPNIPTLSSPVGITSGACSNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMSSQNSPSRLSMQPAKAESKDNKEIASILNEMIQSDNSANEGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPEKKDSASASTAMSVSGQAQGSASIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPAPVTKPAPEEVKLESQSQFSADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVPGVNIKSEILPASLQPTPARSAPRLNRLPELELEAIDNQFGQPGAGDQIPWANNTVTAINQSKPEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLMMEDRPTLYPQPYSSPSPTAGLSGPFQGMVRQKPSLGTMPVQVTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAANAPVGMNMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQIIQQQRAMLMRHQSFGNNIPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLATRSSMVNRGMAGNMGGQFGTGISPQMQQNVFQYPGSGLVPQAEANFAPSLSPGSSMVPMPIPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNNMSITVSMAGGNANVQNMNPMMGQMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDLLKTEADGNQVSKKENPSAELADAITLETWRTSHDMVKSRTLEVRRGCGPWLFPSQPWHCGFLKSSLEFCMTTERPTCLLTGR
Protein: Uncharacterized protein (Q38DW9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLIIILSSERTPFSVPQFVAYYTSSASRNYPDTRGKRCKKWGRHSLRVLSATFALDRRTHHQAMLCRTFVRRVHLFTALVPTNVVQLPHVLKDAQLDAAKKAAIDASPFLGVAPLVPALDLLSDLSNFHQKRDARNLLDECITQCRAELYKPTVSDPFHRLQLHEAIMAAGFYLSTAGSTALKGEATRFVLHHYNFDVRRDTIITRTVHNTLLEVRTSTPESDRLLSDLLLLERRLFGTCRFAPTSGRRWFALGLPLEDIKTEEDLKRVLDIPAVKEKGHFELVVEDTEKMWKKLIVRPMPEETHSLIEQGEFVVSHTEKDLRFECRVQKPPEPIDFWDKLKDTLLRYWVIWFSIWVTFFMVDEEIITITALIFLKWRQTKILEEEAEKTGGKIYIAASTGRALNK
Protein: Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) (Alpha-amylase isozyme 1B) (P17654)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Important for breakdown of endosperm starch during germination.
Interaction partners:
- 4-alpha-glucanotransferase DPE2
- 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic
- Isoamylase 3, chloroplastic
- Isoamylase 1, chloroplastic
- Probable alpha-glucosidase Os06g0675700
- Alpha-1,4 glucan phosphorylase
- Alpha-1,4 glucan phosphorylase
- Os06g0676700 protein
- 1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic
- Isoamylase 2, chloroplastic
Sequence:
MQVLNTMVNKHFLSLSVLIVLLGLSSNLTAGQVLFQGFNWESWKENGGWYNFLMGKVDDIAAAGITHVWLPPPSHSVGEQGYMPGRLYDLDASKYGNEAQLKSLIEAFHGKGVQVIADIVINHRTAEHKDGRGIYCLFEGGTPDSRLDWGPHMICRDDPYGDGTGNPDTGADFAAAPDIDHLNKRVQRELIGWLDWLKMDIGFDAWRLDFAKGYSADMAKIYIDATEPSFAVAEIWTSMANGGDGKPNYDQNAHRQELVNWVDRVGGANSNATAFDFTTKGILNVAVEGELWRLRGEDGKAPGMIGWWPAKATTFVDNHDTGSTQHLWPFPSDKVMQGYAYILTHPGNPCIFYDHFFDWGLKEEIERLVSIRNRQGIHPASELRIMEADSDLYLAEIDGKVITKIGPRYDVEHLIPEGFQVVAHGDGYAIWEKI
Protein: Interferon, alpha-inducible protein 27 (D3Z4L8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAFSGTGTLVASIVSKMTSSAAMVKAGGAVSGTILAGSKGLILLTQSALGSATSALGALKVGTILSGFSASTLAASPIGAGKAARRQRKEGQSKIYLKGFEFSRG
Protein: Bradykinin-potentiating and C-type natriuretic peptides (BPP-CNP) [Cleaved into: Bradykinin-potentiating peptide 1 (BPP 1); Bradykinin-potentiating peptide 2 (BPP 2); Bradykinin-potentiating peptide 3 (BPP 3); Bradykinin-potentiating peptide 4 (BPP 4); Bradykinin-potentiating peptide 5 (BPP 5); Bradykinin inhibitor peptide (BIP); C-type natriuretic peptide (CNP) (Lm-CNP)] (Q27J49)
Organism: Lachesis muta muta (Bushmaster)
Function: Bradykinin-potentiating peptide both inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it. It acts as an indirect hypotensive agent (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:15876444, ECO:0000269|PubMed:16277978}.
Interaction partners:
Sequence:
MFVSRLAASGLLLLALLAVSLDGKPVQQWSHKGWPPRPQIPPLVVQQWSQKPWPPGHHIPPVVVQEWPPGHHIPPLVVQQWSQKKWPPGHHIPPLVVQKWDPPPISPPLLKPHESPAGGTTALREELSLGPEAALDTPPAGPDVGPRGSKAPAAPHRLPKSKGASATSAASRPMRDLRTDGKQARQNWGRMMNPDHHAVGGGGGGGGARRLKGLAKKRVGDGCFGLKLDRIGSMSGLGC
Protein: pre-mRNA splicing regulator USH1G (Jackson shaker protein) (Scaffold protein containing ankyrin repeats and SAM domain) (Usher syndrome type-1G protein homolog) (Q80T11)
Organism: Mus musculus (Mouse)
Function: Plays a role in pre-mRNA splicing by regulating the release and transfer of U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complexes from their assembly site in Cajal bodies to nuclear speckles, thereby contributing to the assembly of the pre-catalytic spliceosome on target pre-mRNAs (By similarity). May also participate in recycling of snRNPs back to Cajal bodies during splicing (By similarity). Plays a role in regulating MAGI2-mediated endocytosis (By similarity). Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. Required for normal hearing.
Subcellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane {ECO:0000269|PubMed:21436032}; Peripheral membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:24608321, ECO:0000269|PubMed:31637240}. Nucleus speckle {ECO:0000250|UniProtKB:Q495M9}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q495M9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24608321}. Photoreceptor inner segment {ECO:0000269|PubMed:24608321}. Note=Detected at the tip of cochlear hair cell stereocilia. Recruited to the cell membrane via interaction with CDH23 or PCDH15 (PubMed:21436032). In photoreceptor cilia, detected predominantly at the cilium base (PubMed:31637240). Expressed in the pericentriolar region of the centrosome (PubMed:24608321). {ECO:0000269|PubMed:21436032, ECO:0000269|PubMed:24608321, ECO:0000269|PubMed:31637240}.
Interaction partners:
- Unconventional myosin-VIIa
- Harmonin
- Cadherin-23
- Whirlin
- Protocadherin-15
- Clarin-1
- Usherin
- PDZ domain-containing protein 7
- Calcium and integrin-binding family member 2
- Transmembrane channel-like protein 1
Sequence:
MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKLVGKLKDKAFREAERRIRECAKMQRKHHERMERRYRRELAERSDTLSFSSLTSSTLSRRLQHMTLGSQLPYSQATLHGTAKGKAKIQKKLERRKQGGEGTFKVSEDGRKSVRSLSGLQLGSDVMFVRQGTYANPKEWGRAPLRDMFLSDEDSVSRATLAAEPAHSEVSTDSGHDSLFTRPGLGTMVFRRNYVSSGLHGLGREDGGLDGAGTPRGRLHSSPSLDDDSLGSANSLQDRSCGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFASLLRHEKIDLEALMLCSDLDLRSISVPLGPRKKILGAVRRRRQALERPLALEDTEL
Protein: Vismay, isoform B (A1Z913)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Achintya, isoform C
- LD38858p
Sequence:
MISPEQEEVNMVLDRHVRQNIKDLMHEAHVHASLLNNEGRDRFHSDSSLDQDSLHAVVGNDLSTEQGANQVQNYHDMMVDSEHHVDINGSLRKRRGNLPKSSVKILKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRREGNDPLHFTISRRGKKVVGATEEVDGAGEIHEGIANVLTNFEQYVQGPNGQMVKMEPEYEDSVIYSWQQAIANNPMGFQSLHSSLQATMIDKIKNYQMRKAAAIGGSAVGSGGAGGSSSNSSPATSILPYSLFGQLPPEFDDEEKPRPPKRVRTRTVAAKSPRENAKQAKQKTGNKQETMYCYKDSYGGIVVSPRSEGEESAQGYESCGPNSEEEVRFETSHDWQSVIKTVFGTEEVSTSAGNNPGTSGSKASVQNTAIWNRNQTAKRDVNQQLTDFESELNIIQASEIQTIDPTNSNQQDIGDNLQADEVFTGAEAEAGQSQLSALSQGTSSDEEGKYKCLYYLVETAMAVRQNDDVQDDDFVYMGD
Protein: Blood-brain barrier large neutral amino acid transporter (SLC7A5 protein) (Solute carrier family 7 member 5) (Q9TU26)
Organism: Bos taurus (Bovine)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MAGSGPKRRAAAATLPANEKEERQARERMLAARGADGAEGEVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAVCGVFSIVGALCYAELGTTITKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPIFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQIGKGDVANLDPKSSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLTPEQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGAREGHLPSILSMIHPRLLTPVPSLVFTCIMTLLYAFSKDIFSVINFFSFFNWLCVALAIAGMLWLRYQKPELERPIKVHLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFLGVWWRDKPKWLLQSIFSTTVLCQKLMHVVPQET
Protein: Acyl-coenzyme A oxidase acox-1.2 (EC 1.3.3.-) (O62137)
Organism: Caenorhabditis elegans
Function: Involved in the first step of peroxisomal beta-oxidation by catalyzing the desaturation of fatty acid-derived side chains of ascaroside pheromones, which regulates development and behavior. Specifically, shortens ascarosides with 5-carbon omega side chain (asc-omega-C5). Does not shorten indol-3-carbonyl(IC)-ascaroside with 7-carbon or 9-carbon side chains. Does not catalyze the desaturation of fatty acids or hydroxylated fatty acids.
Subcellular location: Peroxisome {ECO:0000250|UniProtKB:O62140}.
Interaction partners:
- MaoC-like domain-containing protein
- SCP2 domain-containing protein
- Non-specific lipid-transfer protein-like 2
- Probable 3-ketoacyl-CoA thiolase
- Acetyl-CoA acetyltransferase homolog, mitochondrial
- Acetyl-CoA C-acetyltransferase
- 3-ketoacyl-CoA thiolase
- Enoyl-CoA Hydratase
- Ethylmalonyl-CoA decarboxylase
- Acetyl-coenzyme A synthetase
Sequence:
MANRSIRDGDNPELLEERRMATFDTDKMAAVIYGSEEFARRRREITDAVSKIPELADIKPYPFLTREEKVTEGTRKISILTKYLNQLIDRDNEEESLHLHREVIGYEGHPFALHDALFIPTLQSQASDEQQEKWLERARRREIIGCYAQTELGHGSNLRNLETTAVYDIASQEFVLHTPTTTALKWWPGALGKSCNYALVVAELIIKRNNYGPHFFMVQLRDEKTHIPLKGVTVGDIGPKMNFNAADNGYLGLNNLRVPRTNLLMRHCKVEADGTYVKPPHAKIGYSGMVKIRSQMAMEQGLFLAHALTIAARYSAVRRQGHLDDKQVEVKVLDYQTQQHRLFPSLARAYAFIFTGFETIHLYSQLLKDVDMGNTSGMADLHALTSGLKSVVAHETGEGIEQARMACGGHGYSMASYISVVYGIAIGGCTYEGENMVMLLQLARYLVKSVELIKAGKAKKLGPVASYLADKSDETDLTSLNGYVKMFENMARRQAWKATEKFLKLMESGESREVAWNKSAVELTRASRLHTRLFIIEAFMRRVSRIEDIPVKEVLTDLLHLHVNYELLDVATYALEFMSFTQLDYVRDQLYLYLEKIRPNAVSLVDSFQISDMQLRSVLGRRDGHVYENLFKWAKSSPLNNADVLPSVEKYLKPMMEKAKL
Protein: Olfactory receptor 4D2 (B-lymphocyte membrane protein BC2009) (Olfactory receptor OR17-24) (P58180)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
Sequence:
METGNLTWVSDFVFLGLSQTRELQRFLFLMFLFVYITTVMGNILIIITVTSDSQLHTPMYFLLRNLAVLDLCFSSVTAPKMLVDLLSEKKTISYQGCMGQIFFFHFLGGAMVFFLSVMAFDRLIAISRPLRYVTVMNTQLWVGLVVATWVGGFVHSIVQLALMLPLPFCGPNILDNFYCDVPQVLRLACTDTSLLEFLKISNSGLLDVVWFFLLLMSYLFILVMLRSHPGEARRKAASTCTTHIIVVSMIFVPSIYLYARPFTPFPMDKLVSIGHTVMTPMLNPMIYTLRNQDMQAAVRRLGRHRLV
Protein: DNA-directed RNA polymerases II and V subunit 8A (RNA polymerase I, II and III 16.5 kDa subunit) (AtRPABC16.5) (O81097)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerase V which mediates RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerases II, IV and V subunit 3
- DNA-directed RNA polymerases II, IV and V subunit 10
- DNA-directed RNA polymerases II, IV and V subunit 9B
- DNA-directed RNA polymerases IV and V subunit 5B
- DNA-directed RNA polymerases II, IV and V subunit 11
- DNA-directed RNA polymerase II subunit 7
- DNA-directed RNA polymerases IV and V subunit 3B
- DNA-directed RNA polymerases II, IV and V subunit 9A
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerases II and IV subunit 5A
Sequence:
MASNIILFEDIFVVDQLDPDGKKFDKVTRVQATSHNLEMFMHLDVNTEVYPLAVGDKFTLALAPTLNLDGTPDTGYFTPGAKKTLADKYEYIMHGKLYKISERDGKTPKAELYVSFGGLLMLLKGDPAHISHFELDQRLFLLMRKL
Protein: Signal recognition particle subunit srp68 (Signal recognition particle 68 kDa protein homolog) (O74436)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the 7SL RNA, srp72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P38687}.
Interaction partners:
- Uncharacterized protein C17H9.07
- Signal recognition particle subunit SRP54
- Signal recognition particle subunit srp72
- Signal recognition particle sec65 subunit
- Signal recognition particle subunit srp14
- Signal recognition particle receptor subunit beta
- Signal recognition particle receptor subunit alpha homolog
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein eL31
Sequence:
MDPHVKLSTSLVIIAFRYLPNNFNDSRLGCDNLSTVGLCLKNGTGEVLFSGLIKQMANFYIFPLLLEARSDHFYEGNEYIKYLSHRIHGLRKSLHITQRGGKPKSSVDKRYAEILLFNADRAFQQFVFLRSSQRRHALRRLKRADQFGKELVSFTNAFDCNDHIFYLEAIAFAKYIEGTLNYEKRDWEGSLSAFSISRLSFLVLQNKIDTLAEHEKSVLGELQNQIDSNLRYVAQRTGLQNQTKSLDILMLSSIPKDEEVIQHVNSVDSEILQMTGDEQDSLQTITVIEWRDQRVKIEHPDVVLALYAIHDVKNSPGTIDSKRDRLLAAWARAEEITKSVLDNTGLEDEQKFQTLSICYTYLAYNVVLLRIQRDLAVENDSELVASQAQLRSRQSLYDSIIKNIEIAKELPGIARDTGMTAQLEAQISLAKSKRCQAIADAYQAQDKLASLAMCVRAASYLQQVNDILRNFEEKPHLIAFDIIPELKKDEKELKKKILLLQSLASMGNINQPPKNLSLVETLDSYQTLAELEPSWNLTDADIRAIPAKPLFFDLAITYLGQQTSFDKKKAQPEKPVTSVSKEPKQKNKGFFSSLLGR
Protein: Carbon catabolite repressor protein 4 homolog 1 (CCR4 homolog 1) (EC 3.1.13.4) (Q8W0Z9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Transcription regulator
- Cell differentiation, Rcd1-like protein
- Cell differentiation, Rcd1-like protein
- Probable NOT transcription complex subunit VIP2
- Cell differentiation, Rcd1-like protein
- RNA binding
- RNA binding
- Transcription regulator NOT2/NOT3/NOT5 family protein
- NOT2 / NOT3 / NOT5 family
- Probable CCR4-associated factor 1 homolog 11
Sequence:
MLSVIRVHLPSEIPIVGCELTPYVLLRRPDKTPSTDDVPESAPLEGHFLKYRWFRVQSDKKVAICSVHPSETATLQCLGCLKSKVPVAKSYHCSTKCFSDAWQHHRVLHERAASAATEGNDEEELPRLNSSGSGSGVLSTSVSLTNGSSSVYPSAITQKTGAGGETLVEVGRSKTYTPMADDICHVLKFECVVVNAETKQNVGLSCTILTSRVIPAPSPSPRRLISISGTDVTGHLDSNGRPLSMGTFTVLSYNILSDTYASSDIYSYCPTWALAWTYRRQNLLREIVKYRADIVCLQEVQNDHFEEFFLPELDKHGYQGLFKRKTNEVFIGNTNTIDGCATFFRRDRFSHVKKYEVEFNKAAQSLTEAIIPVSQKKNALNRLVKDNVALIVVLEAKFGSQAADNPGKRQLLCVANTHVNVPHELKDVKLWQVHTLLKGLEKIAASADIPMLVCGDFNTVPASAPHTLLAVGKVDPLHPDLMVDPLGILRPHSKLTHQLPLVSAYSQFAKMGGNVITEQQRRRLDPASSEPLFTNCTRDFIGTLDYIFYTADTLTVESLLELLDEESLRKDTALPSPEWSSDHIALLAEFRCMPRARRNNIL
Protein: Kelch-like protein 3 (Q9UH77)
Organism: Homo sapiens (Human)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation. The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22406640}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22406640}.
Interaction partners:
- Cullin-3
- Serine/threonine-protein kinase WNK4
- Kelch-like protein 12
- E3 ubiquitin-protein ligase RBX1
- Kelch-like ECH-associated protein 1
- Serine/threonine-protein kinase WNK1
- Kelch-like protein 2
- Gigaxonin
- BTB/POZ domain-containing protein KCTD17
- Speckle-type POZ protein
Sequence:
MEGESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL
Protein: Heat shock protein 70 homolog C57A7.12 (P87142)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Zuotin
- Heat shock protein 104
- UBA domain-containing protein 7
- DnaJ homolog 1
- Heat shock protein 78
- Protein psi1
- Heat shock protein 90 homolog
- Hsp70 nucleotide exchange factor fes1
- DnaJ-related protein spj1
- Elongation factor 3
Sequence:
MQLKLTKTLPFSENFIMADSEEYKTVIGISFGNQNSSIAFNRDGKTDVLANEEGNRQIPSILSYHGDQEYHGVQARGQLVRNADNSVTNFRDLLGKSHDELTLHHCHYSANPVNVEGQIGFKITVQEDEESDPKEKILTAHEASVRHLRRLTESAEDFLGTKVNGCVMSVPVYFTDAQRKALESAANEAGLPVLQLIHDPAAVILALMYSEEVLIDKTVVVANFGATRSEVSVVSVKGGLMTILASVHDENLGGEQLTDVLVNFFAKEFEKKNGIDPRKNARSLAKLRAQCEITKRVLSNGTTASAAVDSLADGIDFHSSINRLRYDLAASATLNRMADLVTEAVEKANMEPFDISEVILAGGASNTPKLTSLMESIFPEQTIIRSSSSVTPLQLDPSELTAIGSGVQASLIGHFDAADIAASTDAQVVDVPHLTAPIGINEGENFVTIFDIETALPARKTVEVIAPKEGAAFIPIYEAERSVKVTKVEPEPIDEEEAFSDDEEEEPEEIKERIAIPKTLIATITLPDVSPNAKIELVLQIDAEGKLTASARPKDGKGTNVRGSTA
Protein: Alpha/beta hydrolase fold protein (Q1QEU6)
Organism: Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5)
Interaction partners:
- Alpha/beta hydrolase fold protein
Sequence:
MLLKRLGLATLLSFSVVGCTTAPNTLAINTTQKIIQYERSKSDLTTQSFTLSSGDKIVYAENGNVAGEPLLLVHGFGGNKDNFTRIARQLENYNLIIPDLLGFGDSSKPMAADYHSEAQATRLHELLQAKGLASSIHVGGNSMGGAISVAYAAKYPKEVKSLWLIDSAGFWSAGVPKSLESATLENNPLLVDKKEDFYAMYDFVMSKPPYIPKSVKAVFAQERIANKALESKILAQIVEDNVEQRAKVITEYNIPTLVVWGEEDKVIKPETVTLIKEIIPQSQVITMPKIGHVPMIEAVKDTANDYKAFREGLKN
Protein: BTB domain-containing protein (H2KZQ6)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ubiquitin-like domain-containing protein
- MinK-related peptide, potassium channel accessory subunit protein 4
- Large ribosomal subunit protein eL34
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein eL43
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL38
Sequence:
MACASISYSALAYNGQVTGNMISGAAQQHKKRLVPLRRTDAMTVAERRNYQILDDIFRSGASDCFQQVSSADNGSPQFLKLNIGGTSFMILIDAILRADTTTFLSRFVQLTHTARLKVADAYISADDAYYFQRSPTSFEAVFQYYATGVVHRPSEICPASFLSELDFWRISHQHVGSCCADIIPQKREEEKEEEKVDDTTFDKLMCGKLRRRMWTFLERPGSSMQAKAFELSSTLFVAISVMGLSFGTIPDFQVTHLMPPHNETVVLPNGTVTVVQKVEQMRVEHPAFVFTERICIAFFTVEYCLRFFAAPRKLRFALKPLNLVDLLAIVPFYLELLLTLCGVDDRKLRDLRWAFLVVRILRVLRVIRIIKLGRFSSGLQTFGMTLQRSQKQLQMMTIVLLTGVVFFSTMIYFLEKDEEGTPFTSIPAAYWWCIVTMTTVGYGDAVPATTMGKIIASAAIMCGVLVLALPITIIVDNFIKVAQDEQQAEQQKNDQQSEQLALEAMLNAHD
Protein: Two-component response regulator ARR8 (Response reactor 3) (O80365)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Histidine-containing phosphotransfer protein 3
- Histidine kinase 4
- Histidine kinase 2
- Two-component response regulator ARR18
- Two-component response regulator ARR2
- Two-component response regulator ARR1
- Histidine-containing phosphotransfer protein 5
- Putative two-component response regulator-like APRR6
- Putative two-component response regulator-like APRR4
- Histidine kinase 3
Sequence:
MVMETESKFHVLAVDDSLFDRKMIERLLQKSSCQVTTVDSGSKALEFLGLRVDDNDPNALSTSPQIHQEVEINLIITDYCMPGMTGYDLLKKVKESAAFRSIPVVIMSSENVPARISRCLEEGAEEFFLKPVKLADLTKLKPHMMKTKLKKESEKPVAIEEIVVSKPEIEEEEEESSVIEILPLHQEIESEQLEPMLSSNKRKAMEEVVSTDRSRPKYNDITTSV
Protein: Diacylglycerol O-acyltransferase 1 (CaDGAT1) (EC 2.3.1.20) (A0A161IUT7)
Organism: Corylus americana (American hazelnut)
Function: Major contributor to triacylglycerol (TAG) synthesis and oil accumulation in developing seeds. Catalyzes the acylation of the sn-3 hydroxy group of sn-1,2-diacylglycerol using acyl-CoA. Has a marked preference for oleoyl-CoA as substrate.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5GKZ7}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAISDMPESTGTTATTATMPHGGSDLRRRHNATETTEVSDSNSKTTDPDSGNSVRESVRVRDSSTDESLARKSCEDDGSRSEVVIESANPVTNGNDGGEKIANGEDRRTDFAAVKLAYRPSVPAHRRIKESPLSSDAIFRQSHAGLFNLCIVVLVAVNSRLIIENLMKYGWLIKTGFWFSSRSLRDWPLLMCCLTLPIFPAAAFVVEKLVQWKYISEPVVLLLHFIITTAALLYPVFVILRCDSVVLSGVTLMLFACIVWLKLVSYTHTNYDMRALAKSIDKGDVLPNSLNTDYPYSVSFKSLAYFMVAPTLCYQTSYPRTACIRKSWVVRQLVKLIIFTGVMGFIIEQYINPIVKNSQHPLKGNLLYAIERVLKLSVPNLYVWLCMFYCFFHLWLNILAELLRFGDREFYKDWWNAKTVEEYWRLWNMPVHKWMVRHIYFPCLRNGIPKGVAILIAFFVSAIFHELCIAVPCHIFKLWAFIGIMCQVPLVLITNYLQNKFRNSMVGNMIFWFFFCILGQPMCVLLYYHDLMNRKGKTE