wanglab/gogpt-training-data huggingface dataset:
Protein: SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes) (Q8R550)
Organism: Mus musculus (Mouse)
Function: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration (By similarity). Has an essential role in the stimulation of B cell activation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96B97}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (PubMed:21830225). Colocalizes with ZFP36 in the cytoplasm (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q96B97, ECO:0000269|PubMed:21830225}.
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- E3 ubiquitin-protein ligase CBL-B
- B-cell linker protein
- Epidermal growth factor receptor
- Disabled homolog 1
- Ubiquitin-ribosomal protein eS31 fusion protein
- Son of sevenless homolog 1
- Growth factor receptor-bound protein 2
- Polyubiquitin-B
- E3 ubiquitin-protein ligase CBL-C
Sequence:
MVEAIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKDMKKDLLSNKAPEKPMHDVSSGNALLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGFLPASLLPFPAHGAKGKTTFEGTILYRAAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTMATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPATSTPDPSKTEMDSRTKTKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPSDFDKEGNRPKKPPPPSAPVVKQGAGTTERKHEIKKIPPERPETLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLNRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSALSGILDKDLSDRSNDIDLEGFDSVISSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGIDVSKKTSKTVTISQVSDNKTSLPPKPGTMAAASSGPASLSSVASSPMSSSLGTAGQRASSPSLFSTEGKPKMEPAVSSQAAIEELKMQVRELRTIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
Protein: Protein FAM162A (E2-induced gene 5 protein) (Growth and transformation-dependent protein) (HGTD-P) (Q96A26)
Organism: Homo sapiens (Human)
Function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity).
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:15082785, ECO:0000269|PubMed:16698020}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGSLSGLRLAAGSCFRLCERDVSSSLRLTRSSDLKRINGFCTKPQESPGAPSRTYNRVPLHKPTDWQKKILIWSGRFKKEDEIPETVSLEMLDAAKNKMRVKISYLMIALTVVGCIFMVIEGKKAAQRHETLTSLNLEKKARLKEEAAMKAKTE
Protein: Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] (P51659)
Organism: Homo sapiens (Human)
Function: Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity.
Subcellular location: Peroxisome {ECO:0000305}.
Interaction partners:
- 3-ketoacyl-CoA thiolase, peroxisomal
- Peroxisomal acyl-coenzyme A oxidase 1
- Peroxisomal acyl-coenzyme A oxidase 2
- Peroxisomal acyl-coenzyme A oxidase 3
- Peroxisomal bifunctional enzyme
- Sterol carrier protein 2
- Catalase
- Delta
- 17-beta-hydroxysteroid dehydrogenase type 3
- 17-beta-hydroxysteroid dehydrogenase type 1
Sequence:
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL
Protein: Phytoene synthase 1, chloroplastic (EC 2.5.1.32) (Fruit-ripening-specific protein pTOM5) (P08196)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Catalyzes the reaction from prephytoene diphosphate to phytoene.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- 15-cis-phytoene desaturase, chloroplastic/chromoplastic
- Prolycopene isomerase, chloroplastic
- Uncharacterized protein
- Zeta-carotene desaturase
- Uncharacterized protein
- Uncharacterized protein
- Solanesyl diphosphate synthase
- Uncharacterized protein
- Uncharacterized protein
- Geranylgeranyl diphosphate reductase, chloroplastic
Sequence:
MSVALLWVVSPCDVSNGTSFMESVREGNRFFDSSRHRNLVSNERINRGGGKQTNNGRKFSVRSAILATPSGERTMTSEQMVYDVVLRQAALVKRQLRSTNELEVKPDIPIPGNLGLLSEAYDRCGEVCAEYAKTFNLGTMLMTPERRRAIWAIYVWCRRTDELVDGPNASYITPAALDRWENRLEDVFNGRPFDMLDGALSDTVSNFPVDIQPFRDMIEGMRMDLRKSRYKNFDELYLYCYYVAGTVGLMSVPIMGIAPESKATTESVYNAALALGIANQLTNILRDVGEDARRGRVYLPQDELAQAGLSDEDIFAGRVTDKWRIFMKKQIHRARKFFDEAEKGVTELSSASRFPVWASLVLYRKILDEIEANDYNNFTKRAYVSKSKKLIALPIAYAKSLVPPTKTASLQR
Protein: Receptor-like tyrosine kinase (Tyrosine-protein kinase RYK precursor (EC 2.7.10.1)) (Zgc:158381 protein) (A2RRV7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Protein Wnt-5b
- Protein Wnt
- Protein Wnt
- Protein Wnt-11
- Frizzled class receptor 1
- Frizzled class receptor 2
- Frizzled-4
- Frizzled class receptor 6
- Frizzled-5
- Frizzled-3
Sequence:
MFLPARGSVGGAASAVSRGWPHTVQWRLVGFFLLLLLEGARCLANPSNSPGINNNNRPNVNIFMSEEEVKKLLGLDAELYYVRDDVVNHYALSFVLPVPSDTNSLHFTWHSSSKVDYRLGFHVENTSAMDQPQSNISVQGEVPRTRSVFRVDLFCSGKADGEAVLTVQLNLSTAANFTVLNFKRRKMCYRRIEQPEPPKTLPFPNTTIQRIDASSPNAPTTSTRVFYISVCVCCIVIFLVAIILAVLHLHSMKRVEMDDSVSDSGSSQGLSQPSTQTTQYLRADTPNNATPVTSYPSLRIEKNDLRSVTLLEAKAKVKDIAISRERVTLRDVLHEGTFGRIFHGVLLDEKDPSKEKQVFVKAVKDHASEVQVTMMLTESCKLRGLHHRNLLPISHVCIEDGEKPMVLLPYMNWGNLKLFLRQCKLAEANNPQAISQQDLVHMAIQISCGMSYLARREVIHKDLAARNCVIDNSMQVKITDNALARDLFPMDYHCLGDNENRPVRWMALESLLNNDFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV
Protein: FI21815p1 (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform B) (Q9VMY7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAKPRCSGWQSFIVLMVCLPSCISLSRIDEGPSVTGKPALVRTELRFGRNLDPSKVRVINFKSSTGDDVEILVGKNSRKARAEDAAGSFFVRSADVKRRLVPPTGRVNASGRQITFQHSPALLKQSELAQEMGAYHQRKAEAEQRQAKLIQLQLSKAQNKMIEHQAVQGDFRRGRQIAVDVSWENYRPQLPTQTPKIFRKNISLAADRHWPPFDMDDSVEILPRLQRLSHRPVLSSSRDTEFAASDIQEYLAGERDTRAYISSVSNQGHRPHNLITKHNYNSLPQKSKYVTYLPHSVVVTASAGVATSTTAIPRRQTGGHGSPHHNPIGHGIQSVVEGPAVTLIEGVRVPDSAEDKVKTWRNARVLNNQLVPYPEGYTPPRAQMPSFDR
Protein: Very long chain fatty acid elongase 7 (EC 2.3.1.199) (ELOVL fatty acid elongase 7) (Elongation of very long chain fatty acids protein 7) (Very-long-chain 3-oxoacyl-CoA synthase) (Q9VHX7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Elongation of very long chain fatty acids protein
Sequence:
MDYLTMFYDGWRDLMDNKSDPRTRDYPLMSSPFPTIAISLTYAYIVKVLGPKLMENRKPFELRKVLIVYNAAQVIFSAWLFYESCIGGWLNGYNLRCEPVNYSYSPKAIRTAEGCWWYYFSKFTEFFDTFFFVMRKRYDQVSTLHVIHHGIMPVSVWWGVKFTPGGHSTFFGFLNTFVHIFMYAYYMLAAMGPKVQKYLWWKKYLTVMQMIQFVLVMVHSFQLFFKNDCNYPIGFAYFIGAHAVMFYFLFSNFYKRAYVKRDGKDKASVKANGHANGHVKALKDGDVAPTSNGQANGFHNTFSKFTTDMCNPALNSSTRQRVLVNAGNK
Protein: Glycerol uptake/efflux facilitator protein (P23900)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation: under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Mitogen-activated protein kinase HOG1
- Activator of SKN7 protein 10
- Farnesyl pyrophosphate synthase
- Exosome complex component RRP43
- Regulator of the glycerol channel 1
- Sugar transporter STL1
- Aquaglycerol porin AQY3
- Arsenical-resistance protein 3
- Glycerol kinase
- Mitogen-activated protein kinase SLT2/MPK1
Sequence:
MSNPQKALNDFLSSESVHTHDSSRKQSNKQSSDEGRSSSQPSHHHSGGTNNNNNNNNNNNNSNNNNNGNDGGNDDDYDYEMQDYRPSPQSARPTPTYVPQYSVESGTAFPIQEVIPSAYINTQDINHKDNGPPSASSNRAFRPRGQTTVSANVLNIEDFYKNADDAHTIPESHLSRRRSRSRATSNAGHSANTGATNGRTTGAQTNMESNESPRNVPIMVKPKTLYQNPQTPTVLPSTYHPINKWSSVKNTYLKEFLAEFMGTMVMIIFGSAVVCQVNVAGKIQQDNFNVALDNLNVTGSSAETIDAMKSLTSLVSSVAGGTFDDVALGWAAAVVMGYFCAGGSAISGAHLNPSITLANLVYRGFPLKKVPYYFAGQLIGAFTGALILFIWYKRVLQEAYSDWWMNESVAGMFCVFPKPYLSSGRQFFSEFLCGAMLQAGTFALTDPYTCLSSDVFPLMMFILIFIINASMAYQTGTAMNLARDLGPRLALYAVGFDHKMLWVHHHHFFWVPMVGPFIGALMGGLVYDVCIYQGHESPVNWSLPVYKEMIMRAWFRRPGWKKRNRARRTSDLSDFSYNNDDDEEFGERMALQKTKTKSSISDNENEAGEKKVQFKSVQRGKRTFGGIPTILEEEDSIETASLGATTTDSIGLSDTSSEDSHYGNAKKVT
Protein: Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) (Q8WVV9)
Organism: Homo sapiens (Human)
Function: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
Interaction partners:
- Histone-lysine N-methyltransferase SETD2
- SUMO-conjugating enzyme UBC9
- Receptor-type tyrosine-protein phosphatase C
- KH domain-containing RNA-binding protein QKI
- Heterogeneous nuclear ribonucleoprotein K
Sequence:
MSSSSSSPRETYEEDREYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL
Protein: Cleavage factor two protein 2 (105 kDa protein associated with polyadenylation factor I) (Q12102)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May be involved in poly(A)-site recognition. May be involved in the association of the CPF, CPFIA and RNA polymerase II complexes.
Subcellular location: Nucleus {ECO:0000269|PubMed:12819204, ECO:0000269|PubMed:14562095}.
Interaction partners:
- mRNA 3'-end-processing protein YTH1
- Serine/threonine-protein phosphatase PP1-2
- Endoribonuclease YSH1
- Protein CFT1
- mRNA 3'-end-processing protein RNA15
- RNA end formation protein 2
- Protein PCF11
- Pre-mRNA polyadenylation factor FIP1
- Protein MPE1
- COMPASS component SWD2
Sequence:
MTYKYNCCDDGSGTTVGSVVRFDNVTLLIDPGWNPSKVSYEQCIKYWEKVIPEIDVIILSQPTIECLGAHSLLYYNFTSHFISRIQVYATLPVINLGRVSTIDSYASAGVIGPYDTNKLDLEDIEISFDHIVPLKYSQLVDLRSRYDGLTLLAYNAGVCPGGSIWCISTYSEKLVYAKRWNHTRDNILNAASILDATGKPLSTLMRPSAIITTLDRFGSSQPFKKRSKIFKDTLKKGLSSDGSVIIPVDMSGKFLDLFTQVHELLFESTKINAHTQVPVLILSYARGRTLTYAKSMLEWLSPSLLKTWENRNNTSPFEIGSRIKIIAPNELSKYPGSKICFVSEVGALINEVIIKVGNSEKTTLILTKPSFECASSLDKILEIVEQDERNWKTFPEDGKSFLCDNYISIDTIKEEPLSKEETEAFKVQLKEKKRDRNKKILLVKRESKKLANGNAIIDDTNGERAMRNQDILVENVNGVPPIDHIMGGDEDDDEEEENDNLLNLLKDNSEKSAAKKNTEVPVDIIIQPSAASKHKMFPFNPAKIKKDDYGTVVDFTMFLPDDSDNVNQNSRKRPLKDGAKTTSPVNEEDNKNEEEDGYNMSDPISKRSKHRASRYSGFSGTGEAENFDNLDYLKIDKTLSKRTISTVNVQLKCSVVILNLQSLVDQRSASIIWPSLKSRKIVLSAPKQIQNEEITAKLIKKNIEVVNMPLNKIVEFSTTIKTLDISIDSNLDNLLKWQRISDSYTVATVVGRLVKESLPQVNNHQKTASRSKLVLKPLHGSSRSHKTGALSIGDVRLAQLKKLLTEKNYIAEFKGEGTLVINEKVAVRKINDAETIIDGTPSELFDTVKKLVTDMLAKI
Protein: Malic enzyme (Q385M3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Malate dehydrogenase
- fumarate hydratase
- fumarate hydratase
- malate dehydrogenase
- Pyruvate kinase
- Malate dehydrogenase
- pyruvate dehydrogenase
- malate dehydrogenase
- Pyruvate dehydrogenase E1 component subunit beta
- Pyruvate, phosphate dikinase
Sequence:
MLGRSFKLCVSTNARGIDFLRNRFTNKSTAFTRKEREHLGVVGLLPPAEETLDDHVKRCWTQLTHLEYPINKYQLLQGILSTNTVLYYKIVETYMKETLPIIYTPTVGEACQKYGNIFQRDHGLYISMKERGVIRQTLENLRKPEVEVIVITDGSRILGLGDLGANGMGISIGKCSLYVAAGGINPSRILPVMMDVGTDNEGLRADPQYLGLRQKRPSDEDFYALLDEFMEAASEAWPEAVIQFEDFSNNHCFDMLERYQNKYRCFNDDIQGTGAVIAAGFLNAIEASGIPAEDHRIVFFGAGSAATGVATCIVDLVAAKYKKTFAEVQNNVYLLDTKGVITTTRGDKLAPHKVPWARTDISAEQSKSLSTLVDAVKFVKPTALIGLGAQGGVFTEDILKFMRSYCEKPVIFALSNPSSKVEVTPDNAFKWTDGKAIVATGSPFPPTTLNGKKYEASQGNNLYVFPGIGLGCAIAQPKNIPQEVLQTAAVTLSKLVDRNVMASEGALYPCIDEVREVSKQVAAAVIEKLQEMGLAKEGLPTSKGERLKLVEERMWTPKYLEPEYYLSKKLE
Protein: U2 small nuclear ribonucleoprotein B'' 2 (U2 snRNP B'' 2) (Q8H1S6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in nuclear pre-mRNA splicing.
Subcellular location: Nucleus, Cajal body {ECO:0000269|PubMed:9819359}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9819359}. Cytoplasm {ECO:0000269|PubMed:9819359}. Note=Present in coiled bodies and an interchromatin network. Redistributed throughout the cytoplasm upon entry into mitosis. {ECO:0000269|PubMed:9819359}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- U2 small nuclear ribonucleoprotein A'
- Nuclear protein-like
- Uncharacterized protein At3g23325
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein SmD3b
- Small nuclear ribonucleoprotein SmD3a
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein-associated protein
Sequence:
MLTADIPPNQSIYIKHINEKIKKEELKRSLYCLFSQFGRLLDVVALKTPKLRGQAWVVFTEVTAASNAVRQMQNFPFYDKPMRIQYAKSKSDYVTKAEGSFVPKEKKMKQEEKVERKRHAEETQQPSMPNGATTQNGMPVPPFQPSGQDTMPPNNILFIHNLPIETNSMMLQLLFEQYPGFKEIRMIEAKPGIAFVEYEDDVQSSMAMQALQGFKITPQNPMVVSFAKK
Protein: Opacity protein opA53 (Q04876)
Organism: Neisseria gonorrhoeae
Function: Implicated in a number of adherence functions. OPA proteins are implicated in pathogenesis and are subject to phase variation.
Subcellular location: Cell outer membrane.
Interaction partners:
Sequence:
ASEGNGRGPYVQADLAYAAERITHDYPEQTAPKKAQLSTVSDYFRNIRTHSIHPRVSVGYDFGGWRIAADYARYRKWNNSKYSVSIKELGRNDNSTSNSSHLNIKTQKTEHQENGTFHATSSLGLSAIYDFKLNDKFKPYIGVRVAYGHVKHQVRSVESETTTVTTHNGAPVPQGPTPKPAYHKSRSISSLGFGAVAGVGIDITPKLTLDAGYRYHNWGRLENTRFKTHEASLGVRYRF
Protein: Homeobox protein OTX2 (Orthodenticle homolog 2) (P32243)
Organism: Homo sapiens (Human)
Function: Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Subcellular location: Nucleus {ECO:0000269|PubMed:19414065}.
Interaction partners:
- Hepatocyte nuclear factor 3-beta
- Transcription factor SOX-2
- POU domain, class 5, transcription factor 1
- Homeobox protein SIX6
- Homeobox protein SIX3
- Paired box protein Pax-2
- Recoverin
- Fibroblast growth factor 8
- Transcription factor SOX-1
- Transcription factor SOX-3
Sequence:
MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL
Protein: Coiled-coil domain-containing protein 90B, mitochondrial (Q9GZT6)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:11256614}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MNSRQAWRLFLSQGRGDRWVSRPRGHFSPALRREFFTTTTKEGYDRRPVDITPLEQRKLTFDTHALVQDLETHGFDKTQAETIVSALTALSNVSLDTIYKEMVTQAQQEITVQQLMAHLDAIRKDMVILEKSEFANLRAENEKMKIELDQVKQQLMHETSRIRADNKLDINLERSRVTDMFTDQEKQLMETTTEFTKKDTQTKSIISETSNKIDAEIASLKTLMESNKLETIRYLAASVFTCLAIALGFYRFWK
Protein: Vacuolar basic amino acid transporter 5 (P36172)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transporter required for vacuolar uptake of basic amino acids.
Subcellular location: Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Putative uncharacterized protein YGR259C
- Putative magnesium-dependent phosphatase YER134C
- Uncharacterized transcriptional regulatory protein YNR063W
- Uncharacterized transporter YMR279C
- Protein DOS2
Sequence:
MEETKYSSQQEIEGACGSDASLNARGSNDSPMGLSLYLCLASLTLVLFITALDILIVGTIIDVVAEQFGNYSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIFGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIMFLLTYKAENKGILQQIKDAIGTISSFTFSKFRHQVNFKRLMNGIIFKFDFFGFALCSAGLVLFLLGLTFGGNKYSWNSGQVITYLVLGVLLFIFSLVYDFFLFDKFNPEPDNISYRPLLLRRLVAKPAIIIVNMVTFLLCTGYNGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLVKPLLIFGGVLGVIGAGLMTLMTNTSTKSTQIGVLLLPGFSLGFALQASLMSAQLQITKDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTVFSASFHNKVSRAHLEPYEGKTVDDMILYRLQNYDGSHSTIGNILSDSIKNVFWMDLGFYALGFLFCSFSSNKKLIIPKKDDTPEDNLEDK
Protein: Biotin transporter BioY2 (Biotin ECF transporter S component BioY2) (A2RI45)
Organism: Lactococcus lactis subsp. cremoris (strain MG1363)
Function: Probably a biotin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.
Subcellular location: Cell membrane {ECO:0000305|PubMed:21135102}; Multi-pass membrane protein {ECO:0000305|PubMed:21135102}.
Interaction partners:
- biotin--[biotin carboxyl-carrier protein] ligase
- Energy-coupling factor transporter transmembrane protein EcfT
- Biotin transporter BioY
- Energy-coupling factor transporter ATP-binding protein EcfA1
- Energy-coupling factor transporter ATP-binding protein EcfA2
- Putative cobalt ABC transporter permease protein
- Bifunctional ligase/repressor BirA
- Long-chain acyl-CoA synthetase
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- Putative membrane protein
Sequence:
MQNTKLYSLTLIALGAAIIAVLSPLAIPIGIVPVTLQTLAVGLVATVLKARETFFAILLYLLLGFIGIPVFTGGTSGIAVLFGPTGGFLLAFLVMGTLISWGLHQIKYKTIPAFIINIVGHLLMLVIGTLWLKFFTQVDWSLALKLGFTPFVFVEIIKAILVTIFGLALIRALSHTNKYFTN
Protein: Suppressor of ZYg-1 (Q18320)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNKDNSPSESLVNSSASEDKTVKTSMSANNPSINDSSLPERLPAMCGCDSQNREESANSGVQLSDHANESLSKQADDVIYEGGLEDKDSVFRAIIEDDDACEVLDDGIDNCEVEVRGIKYRIPVAIECHLCNEMMNLCLRRTRYRGQAREYPAYRCNRKGCQTFRSIRKVFGNCMSDVDNSGDATTRTMIYHPPHKVRKTSPGEFSDDDSKEFVVQRVYIPKIDNRNKDQSVKSLSVTDRMRKANQDRAIVFSEFADQLRRDIVANKRVRIKKHVEEDQQGTLFYISKELNPQEVIELQDVIIKTLISMRKIPPPMTMDDLPLFANCPYSKKAVDAGLAKSQNDFWIAFANSAQPPLPAGFIKRSDDTLIYRDPRPYVVPEILKQNSPRKQANAVASYHERKIEQDAIRMKRRQVEKKCRSFASLKREFDMSETEERPRPKLPKTIYQNTRTHSDSLTERSRHFTYDELKHSMEANAEGPSTCRIGISRSERNSESLQWIGLKTYEDSTDGFAKSVNSEGERQQGINGQIDDEVFEDESRFKPVASMQDVMRTLSTPSTLRPPVSPLMKSFSSMDSSNFKNPINAHPPMFFSDPHFLINNNQFNSPTPFYALNSYFPSFPMDSSQVYQNATDEHFTPSGASEVVCTEQTPGHHFTYIHPDSGVRLTDPSAFLTSFVPSPITKVPPINFNDETSRSRSASAPSTSVYNTGEFERSHKKYENEEDEKLMDNQNFSDEQPKE
Protein: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.7) (Q9VSA3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Medium-chain specific acyl-CoA dehydrogenase that catalyzes the first step of mitochondrial fatty acid beta-oxidation, an aerobic process that breaks down fatty acids into acetyl-CoA and allows the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). May contribute to Pink1-mediated regulation of fatty acid and amino acid metabolism, through a mechanism that is independent of its acyl-CoA dehydrogenase activity.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:29563254}. Cytoplasm, cytosol {ECO:0000269|PubMed:29563254}.
Interaction partners:
- HL08109p)
- Electron transfer flavoprotein subunit alpha
- Trifunctional enzyme subunit alpha, mitochondrial
- acetyl-CoA C-acyltransferase
- Probable enoyl-CoA hydratase, mitochondrial
- Carnitine palmitoyltransferase 2
- Acyl-coenzyme A oxidase 1
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
- Acyl-coenzyme A oxidase
Sequence:
MAFLNKLAAPALRQLVSQSRAYAAVSHVSPNGTSFALTEDQLQLQELARKFTREEIIPVAAQYDKSGEYPWPIIKKAWELGLMNNHIPADIGGLDLDVFTTCLSAEELAYGCTGIMTALEASGLGQTPVILSGNKEQKKKYLGRLLEEPLVAAYCVTEPGAGSDVSGIKTRAEKKGDEWVINGQKMWITNGGVANWYFVLARTNPDPKCPPSKAFTGFIVERDSPGLTPGRKELNMGQRASDTRGITFEDVRVPKENVLIGEGAGFKIAMGTFDKTRPPVAAGAVGLAQRCLDEALKYALERKTFGVPIAYHQAVQFMLADMAIGVETSRLAWRLSAWEIDQGRRNSYYASIAKCHAADMANKIASDAVQIFGGNGFNSEYPVEKLMRDAKIYQIYEGTSQIQRLIISRNMYEAAKGQA