wanglab/gogpt-training-data huggingface dataset:
Protein: H-2 class I histocompatibility antigen, K-D alpha chain (H-2K(D)) (P01902)
Organism: Mus musculus (Mouse)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MAPCTLLLLLAAALAPTQTRAGPHSLRYFVTAVSRPGLGEPRFIAVGYVDDTQFVRFDSDADNPRFEPRAPWMEQEGPEYWEEQTQRAKSDEQWFRVSLRTAQRYYNQSKGGSHTFQRMFGCDVGSDWRLLRGYQQFAYDGRDYIALNEDLKTWTAADTAALITRRKWEQAGDAEYYRAYLEGECVEWLRRYLELGNETLLRTDSPKAHVTYHPRSQVDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWAAVVVPLGKEQNYTCHVHHKGLPEPLTLRWKLPPSTVSNTVIIAVLVVLGAAIVTGAVVAFVMKMRRNTGGKGVNYALAPGSQTSDLSLPDGKVMVHDPHSLA
Protein: Voltage-dependent calcium channel beta subunit-associated regulatory protein (Downstream of Stk11 protein) (Q66L44)
Organism: Mus musculus (Mouse)
Function: Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:24751537}; Single-pass type III membrane protein {ECO:0000305|PubMed:24751537}. Cell membrane {ECO:0000269|PubMed:24751537}; Single-pass type III membrane protein {ECO:0000305|PubMed:24751537}. Cell projection, growth cone {ECO:0000269|PubMed:24751537}.
Interaction partners:
Sequence:
MQPTATMATAAATTATVALTTSWDNATSRPTAEPDPILDNYVLLVVVMSLFVGGTLVVLSGVLLLCKRCWEVHQRFNRAMEEAEKTTTTYLDNGTHPIQDPDCRGEDPEGQDTETERFLATSSTGRRVSFNEAALFEQSRKAQDKGRRYTLTEGDFHHLKNARLTHLHLPPLKIATIHECDSGEASAAATPHPATTSKDSLAIFQPPGKTLTGHSVGPSSALPGGPYNSVDFSEISPSTSSDSGEGISLDAGTRGAKAAGPETVPGEMGTGSSGSGTVLQFFTRLRRHASLDGASPYFKVKKWKLEPSQRASSLDTRGSPKRHHFQRQRAASESMEQEGDVPHADFIQYIASAGDSVAFPPPRPFLASPTSPPPTLGRLEAAEAAGGASPETPPEHGISLGPEHAQQQDPQQEQDAEHAQCSYRDLWSLRASLELHAATASDHSSSGNDRDSVRSGDSSGSGSGGGGAAPAFPPPPESPPALRPKDGEARRLLQMDSGYASIEGRGAGDEVSELPAPARSPPRSPRAWPRRPRRDYSIDEKTDALFHEFLRHDPHFDDAPRHRTRAHPHTHARKQWQQRGRQHSDPGGARAATPPGVARPTRAPLRRGDSVDCPPEGRALPITGDDPSIPVIEEEPGGGGGGCPGSGLCVEPAGALLDKLAASLDERLFSPRLAEPVASSQVLIVAAAAPTSPDHSPA
Protein: 3'(2'),5'-bisphosphate nucleotidase CysQ (EC 3.1.3.7) (3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (DPNPase) (P22255)
Organism: Escherichia coli (strain K12)
Function: Converts adenosine-3',5'-bisphosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2).
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02095, ECO:0000269|PubMed:15911532}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_02095, ECO:0000305}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02095, ECO:0000305}.
Interaction partners:
- Adenylyl-sulfate kinase
- Phosphoadenosine 5'-phosphosulfate reductase
- Sulfate adenylyltransferase subunit 2
- Sulfate adenylyltransferase subunit 1
- GTPase ArgK
- Oligoribonuclease
Sequence:
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDVPVLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPGFRVSIY
Protein: Leptin (Obesity factor) (O42164)
Organism: Gallus gallus (Chicken)
Function: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MCWRPLCRLWSYLVYVQAVPCQIFQDDTKTLIKTIVTRINDISHTSVSAKQRVTGLDFIPGLHPILSLSKMDQTLAVYQQVLTSLPSQNVLQIANDLENLRDLLHLLAFSKSCSLPQTSGLQKPESLDGVLEASLYSTEVVALSRLQGSLQDILQQLDISPEC
Protein: NADPH--cytochrome P450 reductase 1 (CPR) (OsCPR1) (P450R) (EC 1.6.2.4) (Q7X7K8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes (By similarity). It can also provide electron transfer to heme oxygenase and cytochrome B5 (By similarity). Can reduce cytochrome c in vitro.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:23053415}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03212}.
Interaction partners:
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Os05g0503300 protein.
- Nitrate reductase
- Nitrate reductase
- Nitrate reductase 1
- Os02g0765900 protein
- Ferredoxin--nitrite reductase, chloroplastic
- Os01g0357500 protein
- Anamorsin homolog 2
- Anamorsin homolog 1
Sequence:
MALALEAARSWAASVLPPELAAAAGGDPLAALAATAAALVAGVVILAVWFRSGGGAPPKAAAPPPRPPPVKIEADADADDGRKRVTVFFGTQTGTAEGFAKAMAEEARARYEKAVFKVVDLDDYAAEDEEYEEKLRKETIVLLFLATYGDGEPTDNAARFYKWFTEGKEKEVWLKDLKYAVFGLGNRQYEHFNKVAKVVDELLEEQGGKRLVPVGLGDDDQCIEDDFTAWKEQVWPELDQLLRDEDDTTGASTPYTAAIPEYRIVFIDKSDVSFQDKSWSLANGSGVIDIHHPVRSNVAVRKELHKPASDRSCIHLEFDISGTGLVYETGDHVGVYSENAIETVEQAEKLLDLSPDTFFSVHADAEDGSPRKGGGSLAPPFPSPCTLRTALLRYADLLNSPKKAALVALAAHASDLAEAERLRFLASPAGKDEYSQWVVASQRSLLEVMAAFPSAKPPLGVFFAAVAPRLQPRYYSISSSPKMAPSRIHVTCALVYGPTPTGRIHQGVCSTWMKNAIPSEYSEECSWAPIYVRQSNFKLPADPTTPIIMIGPGTGLAPFRGFLQERLALKQSGVELGNSVLFFGCRNRNMDYIYEDELQNFIQEGALSELIVAFSREGPAKEYVQHKMTEKATEIWNIVSQGGYIYVCGDAKGMARDVHRALHTIVQEQGSLDSSKTESYVKSLQMDGRYLRDVW
Protein: Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC transporter 1) (P41909)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix.
Subcellular location: Peroxisome membrane; Multi-pass membrane protein.
Interaction partners:
- Peroxisomal long-chain fatty acid import protein 1
- Long-chain-fatty-acid--CoA ligase 2
- Peroxisomal hydratase-dehydrogenase-epimerase
- Acyl-coenzyme A oxidase
- Long-chain-fatty-acid--CoA ligase 1
- 3,2-trans-enoyl-CoA isomerase
- Peroxisome biogenesis factor 10
- Very long-chain fatty acid transport protein
- Long-chain-fatty-acid--CoA ligase 4
- Peroxisomal catalase A
Sequence:
MSTTLAAPAKLKSLLLNLHTHCIGLHVNDVTPKVYFKLLIRHLLQISRSNAAHPKLRRRAQILLVSLFLSGVTLFSGVTYSTFKIILKCYKFYKFPWKRRNRRPLIRRTRSQMQLDSGARIMYIPEVELVDRQSPDDNKFMNATDKKKRKRIFIPPKDNDVYEHDKFLFKNVELERAKNSQLFYSKFLNQMNVLSKILIPTVFDKNFLLLTAQIFFLVMRTWLSLFVAKLDGQIVKNIIAGRGRSFLWDLGCWFLIAVPASYTNSAIKLLQRKLSLNFRVNLTRYIHDMYLDKRLTFYKLIFDAKASNSVIKNIDNSITNDVAKFCDATCSVFANIAKPVIDLIFFSVYLRDNLGTVGVAGIFVNYFITGFILRKYTPPLGKLAGERSASDGDYYNYHLNMINNSEEIAFYQGTAVERTKVKELYDVLMEKMLLVDKVKFGYNMLEDYVLKYTWSGLGYVFASIPIVMSTLATGINSEEKNMKEFIVNKRLMLSLADAGSRLMHSIKDISQLTGYTNRIFTLLSVLHRVHSLNFNYGAVPSILSIRTEDASRNSNLLPTTDNSQDAIRGTIQRNFNGIRLENIDVIIPSVRASEGIKLINKLTFQIPLHIDPITSKSNSIQDLSKANDIKLPFLQGSGSSLLILGPNGCGKSSIQRIIAEIWPVYNKNGLLSIPSENNIFFIPQKPYFSRGGTLRDQIIYPMSSDEFFDRGFRDKELVQILVEVKLDYLLKRGVGLTYLDAIADWKDLLSGGEKQRVNFARIMFHKPLYVVLDEATNAISVDMEDYLFNLLKRYRFNFISISQRPTLIKYHEMLLEIGENRDGKWQLQAVGTDEAITSIDNEIEELERKLERVKGWEDERTKLREKLEII
Protein: Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] (P42167)
Organism: Homo sapiens (Human)
Function: May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.
Subcellular location: Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with the nuclear lamina.; SUBCELLULAR LOCATION: [Isoform Zeta]: Cytoplasm {ECO:0000269|PubMed:18403046}.
Interaction partners:
Sequence:
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDSDRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITETEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDPRKSN
Protein: Endophilin-A3 (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) (SH3p13) (Q62421)
Organism: Mus musculus (Mouse)
Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O35180}. Early endosome membrane {ECO:0000250|UniProtKB:O35180}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35180}. Note=Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons. {ECO:0000250|UniProtKB:O35180}.
Interaction partners:
- Synaptojanin-1
- Huntingtin
- E3 ubiquitin-protein ligase CBL
- Activity-regulated cytoskeleton-associated protein
- Synaptojanin-2
- Endophilin-A2
- E3 ubiquitin-protein ligase CBL-B
- Endophilin-A1
- E3 ubiquitin-protein ligase CBL-C
- Dynamin-2
Sequence:
MSVAGLKKQFHKASQLFSEKISGAEGTKLDEEFLNMEKKIDITSKAVAEILSKATEYLQPNPAYRAKLGMLNTVSKLRGQVKATGYPQTEGLLGDCMLKYGKELGEDSAFGNSLVDVGEALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKRRVGKIPEEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKLELRISLASKVPKREFMPKPVNMSSTDANGVGPSSSSKTPGTDTPADQPCCRGLYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLRGESGFFPINYVEVIVPLPP
Protein: Phosphoinositide phospholipase C (EC 3.1.4.11) (H2LIC9)
Organism: Oryzias latipes (Japanese rice fish) (Japanese killifish)
Subcellular location: Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- inositol-polyphosphate 5-phosphatase
- Kinase
- Inositol 1,4,5-trisphosphate receptor
- Inositol 1,4,5-trisphosphate receptor type 2
- Protein kinase C
- Protein kinase C
- Protein kinase C
- Protein kinase C
- Protein kinase C
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Sequence:
MTELVKMKRSKAPTTRRAEIQQLYQCYSAGMTSLPSSALLKFLHKEQMELTADEDTAESLIDRYEIEETARENRSMTFEGFLRYMESKVCCVFNQAHTSVYQDMDQPLTSYFISSSHNTYLTGDQLIGKSHLDAYVWALRKGCRCLEIDTWDGPDMEPIVYHGYTLTTKILFKDVITTVAQHAFEVSPYPVILSLENHCSQQQQEVMAQYLVSILGDMLLTAPLDHLAGGELPSPNDLKCKILIKNKKKKPRIKTEQATEESADEGEEDYDDLEDEEDDEDHQTKTKFWSPRKAGPKKEEKKVVIAEALSDLVIYTRSVKFIGFSHSRDHQSYFENTSMAEKKARKLASGSGLNFVQHNQRFLTRIYPAGSRMSSSNYNPQEFWNVGSQLVALNFQSLGLPMDLNDGRFQDNGGCGYVLKPAVLLPSDRSFDPICSRHRLKPTHLLLKVISGSNLPVSRSNKGLDPFVRVEIHGIPSDSRKKNTQTVKNNSLSPHWDSDMNFIISVPELCLIRFCVRDQTGLLSSEFVGQYTLPFTSMMKGYRWVPLRSRDGCSLDPASLFIFVCVVAPPAGRIPAVHQDQFAPSSRINHLSSSRSSLSSLIMASARSLLFFCFLFFTFTSSTIPYINGTFLYTSCEEKTDMRPLKHTRTTHCIERIWP
Protein: Protein adenylyltransferase fic-1 (EC 2.7.7.108) (De-AMPylase fic-1) (EC 3.1.4.-) (Q23544)
Organism: Caenorhabditis elegans
Function: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-274 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. In vivo target proteins include the heat-shock 70 family proteins hsp-1 and hsp-3 and the translation elongation factors eef-1A, eef-1G and eef-2. Can AMPylate core histone H3 in vitro. Can also act as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from target proteins (By similarity). Decreases susceptibility to P.aeruginosa-mediated killing and might therefore play a role in the innate immune response.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27138431}; Single-pass membrane protein. Nucleus membrane {ECO:0000269|PubMed:27138431}; Single-pass membrane protein. Note=Predominantly localized to the endoplasmic reticulum and to the nucleus. {ECO:0000269|PubMed:27138431}.
Interaction partners:
- Heat shock 70 kDa protein C
- Endoplasmic reticulum chaperone BiP homolog
- Chitin synthase chs-2
- Protein lgg-2
Sequence:
MSVRRRTHSDDFSYLLEKTRRPSKLNVVQEDPKSAPPQGYSLTTVIIISVLVSLICQHFVPYAVSTLHTVIKNSPKQKSSPPPSNRLNIGFISGNSPEKYAPAVQKPTFLVDPIYDEKWKGIQTAVPVMSTQTDEKRENDPAKVKEAILAAKAAGRSRKDGNLERAMTIMEHAMALAPTNPQILIEMGQIREMHNELVEADQCYVKALAYDPGNSEALVLRARTTPLVSAIDRKMLRSVHDLRDEFNHLQHSTALRRMMRETYFLYVYHTVAIEGNTLSLGQTRAILESGMVIPGKSIREHNEVIGMDAALRFLNCSLLSKEHDEISIDDILEMHRRVLGNADPVEAGRIRTTQVYVGRFTPVSPEYVMEQLKDIVDWLNDESTLTIDPIERAAIAHYKLVLVHPFTDGNGRTARLLLNLIMMRSGFPPVILPVETRAEYYASLHVANLGDLRPFVRYVAKHSEASIQRYIGAMKTSSDNILNSGDSKLTPEESEVSEKIEAECRAGN
Protein: Signal transducer and activator of transcription (C7EY83)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Interaction partners:
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Interferon regulatory factor 9
- Tyrosine-protein kinase
- Tyrosine-protein kinase
Sequence:
MAQWCQLQLLESKYLEQVDQLYDDSFPMDIRQYLSKWIESIDWENVAVQDSLATVRFHDLLAQLDDQHSRFALENNFLLQHNIRKIKRNLQDHFQEDPVHMAMIISRNLKEEQKILAAAKSIETDRENTQTSMVLEKQKLDNKVKDMKNKVQEADQNVKSLEYLQDEHDFKENTLKNREHEMNGLTQKQLEHEKLQIAEMCFKLKFKRGEVVGQLAEVLNIAEAVQSDLISEELAEWKKRQQISCIGGPPNACLDQLQNWFTAVAESLQQVRQQLKELQELEQKYTYDNDPIKQQKGFLEGRALSLFRNLLEHSLVVERQPCMPTHPQRPLVLKTQVQFTVKLRFLVKLQEFNYQLKVKALFDKDVTEKKGFRKFNILGTNTKVMNMEESNGSLAAEFRHLQLKEQKVAGNRTNEGPLIVTEELHCICFESELNQSGLELKLETISLPIVVISNVSQLPSGWASILWYNMLTSEPKNLKFFLSPPAASWGQLSEVLSWQFSSVTKRGLNEEQLGMLADKLLGQKAQRNPEGLVPWTKFCKSLSEKSFPFWLWIEAILDLIKRHLLSLWNDGCILGFVSKEREKALLTGKCPGTFLLRFSESSRDGAITFTWVEHDQYDKPVFHAVEPYTKKELSAVSLPDIIRTYKVMAAENIPENPLRFLYPDIPKDKSFGKYYARASEASEPMDVESSSSTGYMKTELISVSEVHPSRLQDNMMPMSPDVFGELKRSVAPVFQCWTGPKEIDAVMFENTPDLDRN
Protein: Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) (Q8N302)
Organism: Homo sapiens (Human)
Function: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14961121}. Secreted {ECO:0000269|PubMed:14961121}. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted.
Interaction partners:
- Tumor necrosis factor ligand superfamily member 12
Sequence:
MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDLNSEDQKAFSVEHTSCNEEENFANMKKKAKIGIHHKNSPPKVTVPTSGNTIESPLHENISNSTSFKDEKIMETDSEPEEGEITDSQTEDSYDEAITSEGNVTAEDSEDEDEDKIWPPCIRVIVIRSPVLQIGSLFIITAVNPATIGREKDMEHTLRIPEVGVSKFHAEIYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGETVLSFHIHPGSDTCDGCEPGQVRAHLRLDKKDESFVGPTLSKEEKELERRKELKKIRVKYGLQNTEYEDEKTLKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKPSSFEDVHLLQNKNKKNWDKARERFTENFPETKPQKDDPGTMPWVKGTLE
Protein: Transcription factor HFR1 (Basic helix-loop-helix protein 26) (AtbHLH26) (bHLH 26) (Protein LONG HYPOCOTYL IN FAR-RED 1) (Protein REDUCED PHYTOCHROME SIGNALING) (Reduced sensitivity to far-red light) (Transcription factor EN 68) (bHLH transcription factor bHLH026) (Q9FE22)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Atypical bHLH transcription factor that regulates photomorphogenesis through modulation of phytochrome (e.g. PHYA) and cryptochrome signalings. Suppresses the transcriptional regulation activity of PIF4 by forming non-DNA-binding heterodimer.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:19482971, ECO:0000269|PubMed:23224238}.
Interaction partners:
- E3 ubiquitin-protein ligase COP1
- Transcription factor HY5
- Transcription factor LAF1
- Phytochrome B
- Phytochrome A
- Transcription factor PAR1
- Homeobox-leucine zipper protein HAT4
- Cytochrome P450 83B1
- Transcription factor PRE6
- Transcription factor PIF4
Sequence:
MSNNQAFMELGWRNDVGSLAVKDQGMMSERARSDEDRLINGLKWGYGYFDHDQTDNYLQIVPEIHKEVENAKEDLLVVVPDEHSETDDHHHIKDFSERSDHRFYLRNKHENPKKRRIQVLSSDDESEEFTREVPSVTRKGSKRRRRDEKMSNKMRKLQQLVPNCHKTDKVSVLDKTIEYMKNLQLQLQMMSTVGVNPYFLPATLGFGMHNHMLTAMASAHGLNPANHMMPSPLIPALNWPLPPFTNISFPHSSSQSLFLTTSSPASSPQSLHGLVPYFPSFLDFSSHAMRRL
Protein: Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (Mediator complex subunit 27) (A0A494C0K7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADVINVSVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMPHTPPLPSPNRWQPPICSPSLVAAVISIPASSVSDPVSLQYHQRLALSIFLPLTILIGM
Protein: Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Q3UTJ2)
Organism: Mus musculus (Mouse)
Function: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Apical cell membrane {ECO:0000250|UniProtKB:O94875}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O94875}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O94875}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Found at the Z line sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. {ECO:0000250, ECO:0000250|UniProtKB:O94875}.
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- Vinculin
- ENH isoform 1e
- GTP cyclohydrolase 1
- Vacuolar protein sorting-associated protein VTA1 homolog
Sequence:
MNTDSGGCARKRAAMSVTLTSVKRVQSSPNLLAAGRESQSPDSAWRSYNDRNPETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITINGNSGGAVSPVSYYQRPFSPSAYSLPASLNSSIIMQHGRSLDSAETYSQHAQSLDGTMGSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNSPYSAQSHPAAKTQTYRPLSKSHSDNGTDAFKEVPSPVPPPHVPPRPRDQSSTLKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPVSIYQSSIDRSLERPSSSASMAGDFRKRRKSEPAVGPLRGLGDQSSSRTSPGRADLPGSSSTFTKSFISSSPSSPSRAQGGDDSKMCPPLCSYSGLNGTPSGELECCNAYRQHLDVPGDSQRAITFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKTKSESMGSLLCEEDSKESCPMTWASPYIQEVCGNSRSRLKHRSAHNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYEKEQQHRGLLHGWSQSSTEEVPRDVVPTRISEFEKLIQKSKSMPNLGDEMLSPITLEPPQNGLCPKRRFSIESLLEEETQVRHPSQGQRSCKSNTLVPIHIEVTSDEQPRTHMEFSDSDQDGVVSDHSDYVHVEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERAKHENMDRPRRQEMDPGLSKLAFLVSPVPFRRKKILTPQKQTEKAKCKASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPERNSSLHALKRSPMHQPFHPLPPDGASHCPLYQNDCGRMPHSASFPDVDTTSNYHAQDYGSALSLQDHESPRSYSSTLTDLGRSASRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPVQPGEIGEAIAKYNFNADTNVELSLRKGDRIILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKRNAKGAEDYPDPPLPHSYSSDRIYTLSSNKPQRPGFSHENIQGGGEPFQALYNYTPRNEDELELRESDVVDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Protein: Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) (SEC22 vesicle-trafficking protein-like 2) (Q96IW7)
Organism: Homo sapiens (Human)
Function: May be involved in vesicle transport between the ER and the Golgi complex.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- BET1 homolog
- Golgi SNAP receptor complex member 2
- Syntaxin-5
- Synaptobrevin homolog YKT6
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Golgi SNAP receptor complex member 1
- Sec1 family domain-containing protein 1
- Vesicle transport through interaction with t-SNAREs homolog 1A
- BET1-like protein
- Protein transport protein Sec24B
Sequence:
MSMILSASVIRVRDGLPLSASTDYEQSTGMQECRKYFKMLSRKLAQLPDRCTLKTGHYNINFISSLGVSYMMLCTENYPNVLAFSFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQRTKQRYNNPRSLSTKINLSDMQTEIKLRPPYQISMCELGSANGVTSAFSVDCKGAGKISSAHQRLEPATLSGIVGFILSLLCGALNLIRGFHAIESLLQSDGDDFNYIIAFFLGTAACLYQCYLLVYYTGWRNVKSFLTFGLICLCNMYLYELRNLWQLFFHVTVGAFVTLQIWLRQAQGKAPDYDV
Protein: Non-functional pseudokinase ZED1 (AtZED1) (Non-functional pseudokinase ZRK5) (Protein CLUSTERED SILIQUE) (Protein HOPZ-ETI-DEFICIENT 1) (Q8LGB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with RPP13L4/ZAR1, involved in the ambient temperature (above 22 degrees Celsius)-sensitive aerial organ development. Together with RPP13L4/ZAR1, involved in the regulation of the ambient temperature-sensitive intersection of growth and immune response in the absence of pathogens, by repressing the transcription of SNC1. Probable non-functional kinase required for recognition of the Pseudomonas syringae type III effector HopZ1a by RPP13L4/ZAR1 and to trigger subsequent defense responses. May. function as a decoy to trap HopZ1a in the ZAR1 complex for recognition by the plant immune system.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:28499073}. Nucleus {ECO:0000269|PubMed:28499073, ECO:0000269|PubMed:28652264}. Cell membrane {ECO:0000269|PubMed:28652264}. Note=Associates with the plasma membrane in the presence of the Xanthomonas campestris effector XopAC/AvrAC. {ECO:0000269|PubMed:28652264}.
Interaction partners:
- Disease resistance RPP13-like protein 4
- Carboxylesterase SOBER1
- Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1
- Kinesin-like protein KIN-7C, mitochondrial
Sequence:
MSKNNKKKRRWDLKNGGILLEELIASFDGKTNPIRCFSSDQILKATDNFSESRIISSWGYFIWYKGVIEERQVSIKKWSSQNLSSFTEAYRDISVSSQMSGHKNALKLIGCCLEFDLPALVCEYTEHGPLNRDGGLSSGVVLPWKVRLKIAKEIASSVTYLHTAFPETIVHRNINPTNIFIDENWTAKLSDFWFCVAIPEGELYVEDDVKGVIGFVDPDYYWTMKVTEKVDIYSFGVVMLVLLSGRAAVFNGPDEAPMSLNDHVSEVMEKGEFDEIVDKEIWNDLGGDDDLVLRRSQVKAFLRLALRCVRYKKEDPVSGMLEVAKELKLIEKLS
Protein: Sialomucin core protein 24 (MUC-24) (Endolyn) (Multi-glycosylated core protein 24) (MGC-24) (MGC-24v) (CD antigen CD164) (Q9R0L9)
Organism: Mus musculus (Mouse)
Function: Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion (By similarity). Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes.
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q04900}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q04900}. Endosome membrane {ECO:0000250|UniProtKB:Q04900}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q04900}. Cell membrane {ECO:0000250|UniProtKB:Q04900}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q04900}.
Interaction partners:
Sequence:
MSGSSRRLLWAATCLAVLCVSAAQPNITTLAPNVTEVPTTTTKVVPTTQMPTVLPETCASFNSCVSCVNATFTNNITCFWLHCQEANKTYCANEPLSNCSQVNRTDLCSVIPPTTPVPTNSTAKPTTRPSSPTPTPSVVTSAGTTNTTLTPTSQPERKSTFDAASFIGGIVLVLGVQAVIFFLYKFCKSKERNYHTL