wanglab/gogpt-training-data huggingface dataset:
Protein: Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2) (Q9Q0U9)
Organism: Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd)
Function: Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04063}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04063}. Note=PB1 and PA are transported in the host nucleus as a complex. {ECO:0000250|UniProtKB:P03433, ECO:0000255|HAMAP-Rule:MF_04063}.
Interaction partners:
Sequence:
MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESTIIESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETVEERFEITGTMCRLADQSLPPNFSSLEKFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLLAWKQVLAELQDIENEEKIPKTKNMRKTSQLKWALGENMAPEKVDFEDCKDVSDLRQYDSDEPKPRSLASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFLIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHRWEKYCVLRIGDMLLRTEIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCPFQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
Protein: Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) (Q9BRL6)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA alternative splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:9671500}.
Interaction partners:
- SRSF protein kinase 1
- Serine/arginine-rich splicing factor 9
- Dual specificity protein kinase CLK3
- Serine/arginine-rich splicing factor 3
- Transformer-2 protein homolog alpha
- SRSF protein kinase 2
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Serine/arginine-rich splicing factor 7
- Serine/arginine-rich splicing factor 11
- Transformer-2 protein homolog beta
Sequence:
MSCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPREPHTKAPRGFAFVRFHDRRDAQDAEAAMDGAELDGRELRVQVARYGRRDLPRSRQGEPRGRSRGGGYGRRSRSYGRRSRSPRRRHRSRSRGPSCSRSRSRSRYRGSRYSRSPYSRSPYSRSRYSRSPYSRSRYRESRYGGSHYSSSGYSNSRYSRYHSSRSHSKSGSSTSSRSASTSKSSSARRSKSSSVSRSRSRSRSSSMTRSPPRVSKRKSKSRSRSKRPPKSPEEEGQMSS
Protein: Testis secretory sperm-binding protein Li 238E (A0A140VKB1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
Protein: Glutaredoxin-2, mitochondrial (A0A0R4IXU6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MFTRGCFYKSRQAYQSLRMGNFSSSAPGLSSSACGQFVQDIVSSNCVVIFSKTTCPYCKMAKGVFNEIGATYKVVELDEHNDGRRLQETLAELTGARTVPRVFINGQCIGGGSDTKQLHQQGKLLPLIEQCRPCCLNMTPEGSGNSQNQPHQ
Protein: Adenine nucleotide alpha hydrolases-like superfamily protein (Q84JS5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- UDP-sugar pyrophosphorylase
- Tetratricopeptide repeat protein SKI3
Sequence:
METYVDAIGEDTAATTTTAETAANKNKKKLKVMVAIDESKNSFDALEWAVDHLRVVISAEPETGQEGGLLTLLHVHPTYLQYIYPSGGTASAVYATDSVPEPMRKAREESTTNLFTRALEICRGKMVKTETMILEGDPKEMICQAVEQTHVDLLVVGSRGLGMIKRAFLGSVSDYCAQHAKCPILIVRPPRETSTSNTKEHKSK
Protein: Protein LIFEGUARD 3 (AtLFG3) (Q9ZQX7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Heat shock 70 kDa protein 17
- Protein DETOXIFICATION 49
- Subtilisin-like protease SBT1.9
- Endoplasmin homolog
- AAA-ATPase ASD, mitochondrial
- Bax inhibitor 1
- RING-H2 finger protein ATL66
- Putative NAC domain-containing protein 94
- Serine/threonine-protein kinase/endoribonuclease IRE1b
- Heat shock 70 kDa protein BIP3
Sequence:
MYQWNLPYRKDDVETGVSSRRPLLYPAMHENPELRWGFIRKVYSIIAFQLLATVAVAATVVTVRPIALFFATTGLGLALYIVIIITPLIVLCPLYYYHQKHPVNYLLLGIFTLALAFVVGLTCAFTNGKVILESVILTSVVVLSLTLYTFWAARKGYDFNFLGPFLFGALTVLIFFALIQILFPLGRVSVMIYGCLVSIIFCGYIVYDTDNLIKRHTYDEYIWAAVSLYLDIINLFLYLLTVLRALQR
Protein: Beta-mammal toxin Css2 (Css II) (CssII) (P08900)
Organism: Centruroides suffusus (Durango bark scorpion)
Function: Beta toxin that binds site-4 of sodium channels (Nav) and reduces peak current (observed on Nav1.6/SCN8A (IC(50)=307 nM)), shifts the voltage of activation toward more negative potentials (observed on Nav1.6, Nav1.1 (weak), Nav1.2 (weak), and Nav1.7 (weak)), and induces resurgent currents at negative voltages following brief and strong depolarizations (observed on Nav1.6, Nav1.1 (weak), and Nav1.7 (weak)). A reduction of peak current of Nav1.5/SCN7A has been observed in another study (IC(50)=35-40 nM). This toxin is only active on mammals. It has been shown to bind phospholipids.
Subcellular location: Secreted {ECO:0000269|PubMed:2435711}.
Interaction partners:
Sequence:
KEGYLVSKSTGCKYECLKLGDNDYCLRECKQQYGKSSGGYCYAFACWCTHLYEQAVVWPLPNKTCN
Protein: Protein argonaute 10 (Protein PINHEAD) (Protein ZWILLE) (Q9XGW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Required for reliable formation of primary and axillary shoot apical meristems. Specifies leaf adaxial identity by repressing the miR165 and miR166 microRNAs in the embryonic shoot apex, in the shoot apical meristem (SAM) and leaf. Represses the microRNA miR398 which targets CCS1 chaperone mRNAs for translational inhibition. Acts as a negative regulator of AGO1 protein level. Like AGO1, is required for stem cell function and organ polarity. Unlike AGO1, is not subjected to small RNA-mediated repression itself. Essential for multiple processes in development. Coregulates, with GATA18/HAN, the shoot apical meristem (SAM) organization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28463111}.
Interaction partners:
- Dicer-like protein 4
- Endoribonuclease Dicer homolog 2
- Endoribonuclease Dicer homolog 1
- Endoribonuclease Dicer homolog 3
- RNA-dependent RNA polymerase 6
- Protein HESO1
- Small RNA 2'-O-methyltransferase
- Protein HASTY 1
- Protein DCL homolog, chloroplastic
- RNA-dependent RNA polymerase 2
Sequence:
MPIRQMKDSSETHLVIKTQPLKHHNPKTVQNGKIPPPSPSPVTVTTPATVTQSQASSPSPPSKNRSRRRNRGGRKSDQGDVCMRPSSRPRKPPPPSQTTSSAVSVATAGEIVAVNHQMQMGVRKNSNFAPRPGFGTLGTKCIVKANHFLADLPTKDLNQYDVTITPEVSSKSVNRAIIAELVRLYKESDLGRRLPAYDGRKSLYTAGELPFTWKEFSVKIVDEDDGIINGPKRERSYKVAIKFVARANMHHLGEFLAGKRADCPQEAVQILDIVLRELSVKRFCPVGRSFFSPDIKTPQRLGEGLESWCGFYQSIRPTQMGLSLNIDMASAAFIEPLPVIEFVAQLLGKDVLSKPLSDSDRVKIKKGLRGVKVEVTHRANVRRKYRVAGLTTQPTRELMFPVDENCTMKSVIEYFQEMYGFTIQHTHLPCLQVGNQKKASYLPMEACKIVEGQRYTKRLNEKQITALLKVTCQRPRDRENDILRTVQHNAYDQDPYAKEFGMNISEKLASVEARILPAPWLKYHENGKEKDCLPQVGQWNMMNKKMINGMTVSRWACVNFSRSVQENVARGFCNELGQMCEVSGMEFNPEPVIPIYSARPDQVEKALKHVYHTSMNKTKGKELELLLAILPDNNGSLYGDLKRICETELGLISQCCLTKHVFKISKQYLANVSLKINVKMGGRNTVLVDAISCRIPLVSDIPTIIFGADVTHPENGEESSPSIAAVVASQDWPEVTKYAGLVCAQAHRQELIQDLYKTWQDPVRGTVSGGMIRDLLISFRKATGQKPLRIIFYRDGVSEGQFYQVLLYELDAIRKACASLEPNYQPPVTFIVVQKRHHTRLFANNHRDKNSTDRSGNILPGTVVDTKICHPTEFDFYLCSHAGIQGTSRPAHYHVLWDENNFTADGIQSLTNNLCYTYARCTRSVSIVPPAYYAHLAAFRARFYLEPEIMQDNGSPGKKNTKTTTVGDVGVKPLPALKENVKRVMFYC
Protein: Somatostatin receptor type 2 (D7REY1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDSWVFPSSLPNLTEEPLMYDSFILGNESTEPNGTYTGDNTFNQTSTMVITFLYFLVCGIGLCGNALVIYVILRYAKMKTVTNIYIMNLAVADVLFMLGLPFIAIQLALVHWPFGAVLCRVVMTVDSLNQFTSIFCLMVMSIDRYLAVVHPIRSTKWRQRMAKTINLAVWGVSLLVNLPIIIYSGLITKHNSCFCTIVWPEPEEAYYTAFMFYTFVLGFFLPLMVICLCYLLIIIKVKSSGIRVGSTKRKRSERKVTRMVSIVVAVFVFCWLPFYVFNVTSVTGTISTTPFLRSTFAFVVVLGYANSCANPILYAFLSENFKKSFQNVLCRKKVGGLDVIERSDSKQDKSRMMNDPTETQSTLLNGDLQTSI
Protein: Sal-like protein 4 (Zinc finger protein SALL4) (Q8BX22)
Organism: Mus musculus (Mouse)
Function: Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:19483677}.
Interaction partners:
- Homeobox protein NANOG
- POU domain, class 5, transcription factor 1
- Transcription factor SOX-2
- Nuclear receptor subfamily 0 group B member 1
- Steroid hormone receptor ERR2
- Transcription factor CP2-like protein 1
- Histone-binding protein RBBP4
- Nucleus accumbens-associated protein 1
- Histone-binding protein RBBP7
- Protein lin-28 homolog A
Sequence:
MSRRKQAKPQHINWEEGQGEQPQQLPSPDLAEALAAEEPGAPVNSPGNCDEASEDSIPVKRPRREDTHICNKCCAEFFSLSEFMEHKKSCTKTPPVLIMNDSEGPVPSEDFSRAALSHQLGSPSNKDSLQENGSSSGDLKKLGTDSILYLKTEATQPSTPQDISYLPKGKVANTNVTLQALRGTKVAVNQRGAEAPMAPMPAAQGIPWVLEQILCLQQQQLQQIQLTEQIRVQVNMWAAHALHSGVAGADTLKALSSHVSQQVSVSQQVSAAVALLSQKASNPALSLDALKQAKLPHASVPSAASPLSSGLTSFTLKPDGTRVLPNFVSRLPSALLPQTPGSVLLQSPFSAVTLDQSKKGKGKPQNLSASASVLDVKAKDEVVLGKHKCRYCPKVFGTDSSLQIHLRSHTGERPYVCPICGHRFTTKGNLKVHLQRHPEVKANPQLLAEFQDKGAVSAASHYALPVPVPADESSLSVDAEPVPVTGTPSLGLPQKLTSGPNSRDLMGGSLPNDMQPGPSPESEAGLPLLGVGMIHNPPKAGGFQGTGAPESGSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTTVKTQHSCPICQKKFTNAVMLQQHIRMHMGGQIPNTPLPESPCDFTAPEPVAVSENGSASGVCQDDAAEGMEAEEVCSQDVPSGPSTVSLPVPSAHLASPSLGFSVLASLDTQGKGALPALALQRQSSRENSSLEGGDTGPANDSSLLVGDQECQSRSPDATETMCYQAVSPANSQAGSVKSRSPEGHKAEGVESCRVDTEGRTSLPPTFIRAQPTFVKVEVPGTFVGPPSMPSGMPPLLASQPQPRRQAKQHCCTRCGKNFSSASALQIHERTHTGEKPFVCNICGRAFTTKGNLKVHYMTHGANNNSARRGRKLAIENPMAALSAEGKRAPEVFSKELLSPAVSVDPASWNQYTSVLNGGLAMKTNEISVIQSGGIPTLPVSLGASSVVSNGTISKLDGSQTGVSMPMSGNGEKLAVPDGMAKHQFPHFLEENKIAVS
Protein: Probable cation-transporting ATPase 13A5 (EC 7.2.2.-) (P5-ATPase isoform 5) (Q4VNC0)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEENSKKDHRALLNQGEEDELEVFGYRDHNVRKAFCLVASVLTCGGLLLVFYWRPQWRVWANCIPCPLQEADTVLLRTTDEFQRYMRKKVFCLYLSTLKFPVSKKWEESLVADRHSVINQALIKPELKLRCMEVQKIRYVWNDLEKRFQKVGLLEDSNSCSDIHQTFGLGLTSEEQEVRRLVCGPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVKLHNLVEDHNKVQVTIIVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQMENTMPWKCHSLEDYRKHVLFCGTEVIQVKPSGQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLACLGVMGFFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWGTVPTADNCFQEAHSFASGQAVPWSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEDCIVDSCKFGTSVSNIIKPGPKASKSPVEAIITLCQFPFSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELRSYTVQGFRVIALAHKTLKMGNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSQVIIVEADEPEEFVPASVTWQLVENQETGPGKKEIYMHTGNSSTPRGEGGSCYHFAMSGKSYQVIFQHFNSLLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQCVPHLIREGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLTMSSTHAYPKLAPYRPAGQLLSPPLLLSIFLNSCFSCIVQISAFLYVKQQPWYCEVYQYSECFLANQSNFSTNVSLERNWTGNATLIPGSILSFETTTLWPITTINYITVAFIFSKGKPFRKPIYTNYIFSFLLLAALGLTIFILFSDFQVIYRGMELIPTITSWRVLILVVALTQFCVAFFVEDSILQNHELWLLIKREFGFYSKSQYRTWQKKLAEDSTWPPINRTDYSGDGKNGFYINGGYESHEQIPKRKLKLGGQPTEQHFWARL
Protein: Protein AUXIN-REGULATED GENE INVOLVED IN ORGAN SIZE (AtARGOS) (Q6NMD6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes cell proliferation-dependent organ growth. Takes part in the AXR1-dependent auxin signaling pathway that requires ANT during organogenesis.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q7X6L2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7X6L2}. Nucleus {ECO:0000269|PubMed:12953103}. Cytoplasm {ECO:0000269|PubMed:12953103}. Endoplasmic reticulum {ECO:0000269|PubMed:21457262}.
Interaction partners:
- Methionine--tRNA ligase, cytoplasmic
- Protein ORGAN SIZE RELATED 1
- ERBB-3 BINDING PROTEIN 1
- Cytochrome P450 78A5
- Cyclin-D3-1
- Transmembrane protein
- Protein REVERSION-TO-ETHYLENE SENSITIVITY1
- Small polypeptide DEVIL 16
- GRF1-interacting factor 1
- Auxin response factor 2
Sequence:
MIREISNLQKDIINIQDSYSNNRVMDVGRNNRKNMSFRSSPEKSKQELRRSFSAQKRMMIPANYFSLESLFLLVGLTASLLILPLVLPPLPPPPFMLLLVPIGIMVLLVVLAFMPSSHSNANTDVTCNFM
Protein: Bactericidal protein diptericin B (Q9GN49)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
LFIGLACAFSSAWAYPYPDPREIVNLQPEPLAYAPNFDVPLHRVRRQFQLNGGGGGSPKQGFDLSLNGRAPVWQSPNGRHSFDATGSYAQHLGGPYGNSRPQWGAGGVY
Protein: AP-1 complex subunit gamma (B2RYN6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00029433}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKADCASGVFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPSEIVQTNGETEPAPLETKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAPTSKPASAGGELLDLLGDITLTGAPAAAPTPASVPQITQPPFLLDGLSSQPLFNDIAPGIPSITAYSKNGLKIEFTFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGTITQVIKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSWQ
Protein: Gallate dioxygenase (EC 1.13.11.57) (Gallate degradation protein A) (Q88JX5)
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Function: Ring-cleavage dioxygenase that acts specifically on gallate to produce the keto-tautomer of 4-oxalomesaconate. Mediates the first step of gallate degradation pathway.
Interaction partners:
- 4-oxalomesaconate tautomerase
- DNA ligase B] B)
- DNA ligase])
- 4-carboxy-4-hydroxy-2-oxoadipic acid aldolase
- 2-pyrone-4,6-dicarboxylic acid hydrolase
- HTH-type transcriptional regulator GalR
- 4-oxalmesaconate hydratase
Sequence:
MADEGGNPRDLPPVGGHAALSRHIGQSLMADEFDMSFFRDKPLDHGFFSPMSALLPCDESWPVQIVPLQVGVLQLPIPTARRCYKLGQALRRAIESYPEDLKVAIVATGGVSHQVHGERCGFNNPEWDAQFLDLLVNDPQRLTEMTLAEYATLGGMEGAEVITWLIMRGTLSANVERKHQSYYLPSMTGIATLLLENRDQALPAPVNERHRQHMQHQLAGAEQLEGTYPYTLERSAKGYRLNKFLHRMIEPQWRQRFLSEPEALYREAGLSEEESDLLRRRDWRGLIHYGVIFFVLEKLGAVLGVSNLDIYAAMRGQSIEDFMKTRNQQVRYSVAGKAPN
Protein: Leucine-Rich Repeat protein (Q19988)
Organism: Caenorhabditis elegans
Interaction partners:
- Cullin-2
- RING-box protein 1
- RNA polymerase II transcription factor SIII p18 subunit
- Elongin-C
- Early embryogenesis protein zyg-11
- DNA replication licensing factor MCM7
- Zyg eleven-related protein 1
- Minichromosome loss protein Mcl1 middle region domain-containing protein
- E3 ubiquitin-protein ligase trul-1
- DNA replication licensing factor MCM3
Sequence:
MRLPCEVVFARYKANAGVNPKPTKSQKGFVILQKLRQTPPQYQITVAVAGDKTGNKFELNKPPIILDKFIAQGKTTITFQTTPAVMVCISKANPEALAQLIEAIRKIVKGENVDIEKVKVKSSDFKPTTITVNNQATYKKQMQSCSEFLKTLKIEPIDLRRPDKAWRFCHNLTRLTLNGNPIGAHNRDLDVFSKLKQLQSLEMRSCSLELIPVPAMCTMFRELPTSISLLDFGDNHLSIFPPIFHLKQLKIINAAHNAIKYLPSRIGVLQNLNTIDVSNNLMTALPYVFSKIPSIEHVGINANDQMVRLEEEIGPIFIRRLLTKVDNIEYTHEGGVDKLGTIAANAIHREECSKSMKFGRQFLPLSLRFDMDDLMFEKPGISSLELCTGCVRLRHIRYIRPLIIQSRQIANSVDVIGRFVTFDRLLCIDCYRRTTSTNNGEPPFQCDYFQFAV
Protein: Plasminogen activator inhibitor 2, macrophage (PAI-2) (Serpin B2) (P12388)
Organism: Mus musculus (Mouse)
Function: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival.
Subcellular location: Cytoplasm. Secreted, extracellular space.
Interaction partners:
- Tissue-type plasminogen activator
- Plasminogen activator inhibitor 1
- Vitamin K-dependent protein C
- Urokinase-type plasminogen activator
- Albumin
- Thyroglobulin
- T-cell surface glycoprotein CD4
- Urokinase plasminogen activator surface receptor
- Granulocyte-macrophage colony-stimulating factor
- Interleukin-4
Sequence:
MEELSMANTMFALNLLKQIEKSNSTQNIFISPWSISSTLAIVLLGAGGNTEQQMAKVLQFNEIGSYGITTRNPENFSGCDFAQQIQKENYPSAILQAQAGDKIHSAFSSLSSTINTPQGDYLLESANKLFGEKSARFKEEYIQLSKKYYSTEPEAVDFLECAEEAREKINSWVKTQTKGEIPNLLPEGSVDEDTKMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSHESIPVQMMFLHAKLNIGYIKDLKTQILELPHTGNISMLLLLPDEIEDASTGLELLESEINFANFNKWISKDTLDEDDVVVYIPKFKLAQSYELKSILQSMGMEDAFNKGKANFSGMSERNDLFLSEVFHQASVDVTEEGTVAAGGTGAVMTGRTGHGGPQFVADHPFLFFIMDKITHTILFVGRFSSP
Protein: Cholesteryl ester transfer protein (Lipid transfer protein I) (P22687)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:24293641}. Note=Secreted in plasma. {ECO:0000250|UniProtKB:P47896}.
Interaction partners:
- Apolipoprotein B
- Apolipoprotein C-I
- Apolipoprotein A-I
- Phosphatidylcholine-sterol acyltransferase
- Hepatic triacylglycerol lipase
- Serum paraoxonase/arylesterase 1
- Apolipoprotein F
- P-type phospholipid transporter
- Lipoprotein lipase
- Apolipoprotein A-II
Sequence:
ACPKGASYEAGIVCRITKPALLVLNQETAKVVQTAFQRAGYPDVSGERAVMLLGRVKYGLHNLQISHLSIASSQVELVDAKTIDVAIQNVSVVFKGTLNYSYTSAWGLGINQSVDFEIDSAIDLQINTELTCDAGSVRTNAPDCYLAFHKLLLHLQGEREPGWLKQLFTNFISFTLKLILKRQVCNEINTISNIMADFVQTRAASILSDGDIGVDISVTGAPVITATYLESHHKGHFTHKNVSEAFPLRAFPPGLLGDSRMLYFWFSDQVLNSLARAAFQEGRLVLSLTGDEFKKVLETQGFDTNQEIFQELSRGLPTGQAQVAVHCLKVPKISCQNRGVVVSSSVAVTFRFPRPDGREAVAYRFEEDIITTVQASYSQKKLFLHLLDFQCVPASGRAGSSANLSVALRTEAKAVSNLTESRSESLQSSLRSLIATVGIPEVMSRLEVAFTALMNSKGLDLFEIINPEIITLDGCLLLQMDFGFPKHLLVDFLQSLS
Protein: BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) (Q80Y61)
Organism: Mus musculus (Mouse)
Function: Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Note=Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts. {ECO:0000250}.
Interaction partners:
- Dol-P-Man:Man
- Dol-P-Man:Man
- Synaptojanin-1
- Potassium voltage-gated channel subfamily KQT member 5
- AP-2 complex subunit sigma
- Aftiphilin
- SH3-containing GRB2-like protein 3-interacting protein 1
- AP-2 complex subunit mu
- Phosphatidylinositol-binding clathrin assembly protein
- Cation-independent mannose-6-phosphate receptor
Sequence:
MAPEMDQFYRSTMAIYKSIMEQFNPALENLVYLGNNYLRAFHALSEAAEVYFSAIQKIGEQALQSSTSQILGEILVQMSDTQRHLNSDLEVVVQTFHGDLLQHMEKNTKLDMQFIKDSCQHYEIEYRHRAANLEKCMSELWRMERKRDKNAREMKESVNRLHAQMQAFVSESKRAAELEEKRRYRFLAEKHLLLSNTFLQFLGRARGMLQNRVLLWKEQSEASRSPSRAHSPGLLGPALGPPYPSGRLTPTRLDMPPRPLGEYGSPRSRHGSGSYGPEPAEARSASQLEPDRRSLPRTPSASSLYASSTQRSRSNSFGERLGGGGARRVRALVSHSEGANHTLLRFSAGDVVEVLVPEAQNGWLYGKLEGSSASGWFPEAYVKPVEEIPVNPMNPVAPMNSMAPMSPMNELPSRSYPLRGSHSLDDLLDRPGNPTASSEYWDSQSRSRTPSRVPSRAPSPAPPPLPSSRRSSVGSMGAATDVKKLMSWEQNPPELFPRGTNPFATVKLRPTVTNDRSAPLIR
Protein: Putative cytochrome P450 135A1 (EC 1.14.-.-) (P9WPN1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Polyketide synthase Pks13
- Possible oxygenase
- Peptide synthetase MbtE
- Possible electron transfer protein FdxB
- Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1
- 3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component
- DNA polymerase I
- ERCC4 domain-containing protein
Sequence:
MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFSLRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEHARMRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFGVTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIASRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLWELAHAPEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPAGTVVNTSILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTEGAVILQEIFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP
Protein: Small ribosomal subunit protein eS10A (40S ribosomal protein S10-A) (Q08745)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eS10 plays a role as a positive regulator of the GCN2 kinase activity by stimulating GCN1-mediated GCN2 activation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein uS4B
- Small ribosomal subunit protein eS19A
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein uS13A
- Large ribosomal subunit protein eL38
- Small ribosomal subunit protein uS12A
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS9A
- Small ribosomal subunit protein eS24A
Sequence:
MLMPKEDRNKIHQYLFQEGVVVAKKDFNQAKHEEIDTKNLYVIKALQSLTSKGYVKTQFSWQYYYYTLTEEGVEYLREYLNLPEHIVPGTYIQERNPTQRPQRRY