wanglab/gogpt-training-data huggingface dataset:
Protein: Major viral transcription factor ICP4 (Alpha-4 protein) (Infected cell protein 4) (Transcriptional activator IE175) (P08392)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: Plays an essential role in the regulation of viral gene expression by both activating and repressing host RNA polymerase II-mediated transcription. Binds with high affinity to the sequence 5'-ATCGTC-3'. Activates transcription by recruiting a form of the host TFIID to promoters and stabilizing the pre-initiation complex formation. Negatively regulates its own transcription. This immediate early (IE) protein is absolutely necessary for the transition from IE transcription to later viral gene transcription.
Subcellular location: Host nucleus {ECO:0000269|PubMed:17959681}. Host cytoplasm {ECO:0000269|PubMed:17959681}. Virion tegument {ECO:0000269|PubMed:17959681}. Note=Localizes to the cytoplasm when phosphorylated. {ECO:0000250}.
Interaction partners:
Sequence:
MASENKQRPGSPGPTDGPPPTPSPDRDERGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAFRADDDDGDEYDDAADAAGDRAPARGREREAPLRGAYPDPTDRLSPRPPAQPPRRRRHGRWRPSASSTSSDSGSSSSSSASSSSSSSDEDEDDDGNDAADHAREARAVGRGPSSAAPAAPGRTPPPPGPPPLSEAAPKPRAAARTPAASAGRIERRRARAAVAGRDATGRFTAGQPRRVELDADATSGAFYARYRDGYVSGEPWPGAGPPPPGRVLYGGLGDSRPGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVVPGDVALDQACFRISGAARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENAALTGAAGSPGAGADDEGVAAVAAAAPGERAVPAGYGAAGILAALGRLSAAPASPAGGDDPDAARHADADDDAGRRAQAGRVAVECLAACRGILEALAEGFDGDLAAVPGLAGARPASPPRPEGPAGPASPPPPHADAPRLRAWLRELRFVRDALVLMRLRGDLRVAGGSEAAVAAVRAVSLVAGALGPALPRDPRLPSSAAAAAADLLFDNQSLRPLLAAAASAPDAADALAAAAASAAPREGRKRKSPGPARPPGGGGPRPPKTKKSGADAPGSDARAPLPAPAPPSTPPGPEPAPAQPAAPRAAAAQARPRPVAVSRRPAEGPDPLGGWRRQPPGPSHTAAPAAAALEAYCSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPAPAAQAACGGGDDDDNPHPHGAAGGRLFGPLRASGPLRRMAAWMRQIPDPEDVRVVVLYSPLPGEDLAGGGASGGPPEWSAERGGLSCLLAALANRLCGPDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHAYLACELLPAVQCAVRWPAARDLRRTVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPREYRRAVLPALDGRAAASGTTDAMAPGAPDFCEEEAHSHAACARWGLGAPLRPVYVALGREAVRAGPARWRGPRRDFCARALLEPDDDAPPLVLRGDDDGPGALPPAPPGIRWASATGRSGTVLAAAGAVEVLGAEAGLATPPRREVVDWEGAWDEDDGGAFEGDGVL
Protein: Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (A0A8I6A6W5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
LSGRMIFDPTMSKKKKKKKKPFMLDEEGDAQTEETQPSETKEVEPEPAEEKDVEADEEDSRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEAIKDVKIESDAQEPAEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDSKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAKAN
Protein: Peroxisomal membrane protein 11A (Peroxin-11A) (Peroxisomal biogenesis factor 11A) (Protein PEX11 homolog alpha) (PEX11-alpha) (Q9Z211)
Organism: Mus musculus (Mouse)
Function: May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface.
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:O75192}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O75192}.
Interaction partners:
- Peroxisomal membrane protein 11C
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein 11B
- Peroxisomal membrane protein PEX13
- Peroxisomal membrane protein PEX16
- Peroxisomal membrane protein PEX14
- Peroxisomal acyl-coenzyme A oxidase 1
- Peroxisome biogenesis factor 10
- Peroxisomal bifunctional enzyme
- Peroxisomal membrane protein 4
Sequence:
MDAFIRVANQSQGRDRLFRATQHACMLLRYLLESKADKEAVVLKLKRLETSVSTGRKWFRLGNVFHAIQATEQSIQAADLAPRLCLTLANLNRVVYYICDTVLWAKSVGLTSGVNREKWQRWAARHYYYFLLLSLVRDLYEILLQMGQVARDRAKREKSSRDPPKYSVANEETEWLQSFLLLLFQSLKRHPPLLLDTVKNFCDILIPLNQLGIYKSNLGVVGLGGLISSLAGLLTVVYPQLKLKAR
Protein: Atonal bHLH transcription factor 1b (Atonal homolog 1b) (B3DH94)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MTAKTKLLHWTDGHFREEFSISEHPRLTRSDPRAWMTSAAPEYSSAVENYARTAADSPMEKYISSPQAASEDHHAGSKARPGSKASVSGPQRHRRVAANARERRRMHGLNRAFDKLRSVIPSLENEKKLSKYDTLQMAQIYITELSELLEGVVQSGAPGSQRTAIPYAIDATSGNFATEKHDSTNNASDGESSHFSDTEEGHTGGR
Protein: Somatoliberin (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (P63292)
Organism: Bos taurus (Bovine)
Function: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
Subcellular location: Secreted.
Interaction partners:
- Growth hormone-releasing hormone receptor
- Somatotropin
- Short palate, lung and nasal epithelium carcinoma-associated protein 2A
- Amelogenin, X isoform
- Retinal guanylyl cyclase 1
- Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
- Peripherin-2
- Appetite-regulating hormone
- Somatostatin
- Protein phosphatase 1B
Sequence:
MLLWVFFLVTLTLSSGSHGSLPSQPLRIPRYADAIFTNSYRKVLGQLSARKLLQDIMNRQQGERNQEQGAKVRLGRQVDGVWTDQQQMALESTLVSLLQERRNSQG
Protein: [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) (A0A8I5ZPK6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKTFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEIVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPDLDLKEKVEAEVLSTDIQPSPERGTRMNIPPKRTRRVKSQSDSGEVNRNTELKKLQIFGAGPKVVGLAVGAKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLLPPLPDVPKGDWRCPKCVAEECNKPREAFGFEQAIREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPIKDGQRKMLPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVVMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCSCPMQNKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVNRVTEALSASFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCGSVAQLLLSKKQKHRQSSDSGKTRTKLTVEELKAFVQQLVSLPCVISQTRQVKNLLDDVEEFHERAQEAMMDETPDSSKLQVLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSMANLENIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLDALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKEIIEKEKEKDLDLEPLSDLEEGLEETRDAAMVVAVFKEREQKEIEAMHSLRAANLAKMTIVDRIEEVKFCICRKTASGFMLQCELCKDWFHNGCVPLPKSGSQKKGSSWQAKDVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPHQAMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSVEEKPLKMKGKDSSEKKRKRKLEKVEQFFGEGKQKTKELKKIDKPKKKKLKLNVDKSKELNKLAKKLAKEEERKKKKEKAAAAKVELAKESTEKKRERKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCKDKVRCRGSLTAVKGQS
Protein: Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1) (Q9JIB0)
Organism: Mus musculus (Mouse)
Function: May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (By similarity). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes.
Subcellular location: Nucleus {ECO:0000269|PubMed:10811801, ECO:0000269|PubMed:11733047}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9HD47}. Cytoplasm {ECO:0000269|PubMed:18184654}. Cell membrane {ECO:0000250|UniProtKB:Q9HD47}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9HD47}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9HD47}. Note=Shuttles between the nucleus and cytoplasm. {ECO:0000269|PubMed:11733047}.
Interaction partners:
- Ran-specific GTPase-activating protein
- GTP-binding nuclear protein Ran
- GTP-binding nuclear protein Ran, testis-specific isoform
- Sodium channel regulatory subunit beta-2
- Glycerol-3-phosphate dehydrogenase 1-like protein
Sequence:
MEPNRNCPLFGGAFSAILPTGAIDVSDLRPVPDNQEVFCHPVTDQSLIIELLELQAHVQGEAAARYHFEDVGRVQGARAVHVLSVQPLCLENLSLRGCCQDAWSLSGKQQVAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPCHSRSLGPENLSCPPWSLSNFEQLVTSLTLHDPNLFGPQ
Protein: Respiratory growth induced protein 2 (P40188)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YMR206W
- Protein YIG1
Sequence:
MTKKDKKAKGPKMSTITTKSGESLKVFEDLHDFETYLKGETEDQEFDHVHCQLKYYPPFVLHDAHDDPEKIKETANSHSKKFVRHLHQHVEKHLLKDIKTAINKPELKFHDKKKQESFDRIVWNYGEETELNAKKFKVSVEVVCKHDGAMVDVDYKTEPLQPLI
Protein: Acrosin (EC 3.4.21.10) [Cleaved into: Acrosin light chain; Acrosin heavy chain] (P10323)
Organism: Homo sapiens (Human)
Function: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
Interaction partners:
- Zona pellucida sperm-binding protein 2
- Izumo sperm-egg fusion protein 1
- Spermatogenesis-associated protein 16
- Spermatid nuclear transition protein 1
- Serine peptidase inhibitor Kazal type 2
Sequence:
MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPASPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTSTS
Protein: Triacylglycerol lipase SDP1L (EC 3.1.1.3) (Protein SDP1-LIKE) (Q9M1I6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the release of fatty acids from the oil body in germinating seedlings. Can hydrolyze triacylglycerols in vitro.
Subcellular location: Lipid droplet {ECO:0000250|UniProtKB:Q9LZA6}. Membrane {ECO:0000250|UniProtKB:Q9LZA6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9LZA6}. Note=Associates with the oil body membrane. {ECO:0000250|UniProtKB:Q9LZA6}.
Interaction partners:
- Triacylglycerol lipase 1
- Phosphatidate phosphatase PAH2
- Phosphatidate phosphatase PAH1
- Alpha/beta-Hydrolases superfamily protein
- Alpha/beta-Hydrolases superfamily protein
- Diacylglycerol O-acyltransferase 2
- Alpha/beta-Hydrolases superfamily protein
- 1-acyl-sn-glycerol-3-phosphate acyltransferase 2
- Diacylglycerol O-acyltransferase 1
- Lysophospholipid acyltransferase 2
Sequence:
MDISNEAGVDAFSIIGPTTIIGRTIAVRILFCNSVSIFRHKVFRILKFFLRGGRVLLSPFVSLLHPRNPQGILVMVTTMAFLLNRYTSLKAKAEMAYRRKFWRNMMRAALTYEEWSHAAKMLDKETPKVNETDLFDVELVSNKLDELKHRRHEGSLRDIIFCMRADLVRNLGNMCNPELHKGRLHVPRLIKEYIDEVSTQLRMVCDMDTEELSLEEKLSFMHETRHAYGRTALLLSGGASLGAFHLGVVKTLVEHKLLPRIIAGSSVGSVMCAVVGTRSWPELQSFFEGSWHALQFFDQMGGIFTTVKRVMTQGAVHEIRHLQWKLRNLTNNLTFQEAYDITGRILGITVCSLRKHEPPRCLNYLTSPHVVIWSAVTASCAFPGLFEAQELMAKDRTGEIVPYHPPFNLDPEEGSASVRRWRDGSLEMDLPMIQLKELFNVNHFIVSQANPHIAPFLRMKEFVRACGGRFAAKLAQLAEMEVKHRCNQVLELGLPLREVASLFAQEWEGDVTIVMPATFSQYLKIIQNPSNVEIQKAANQGRRCTWEKLAVIKANFGIELALDECVTVLNHMRRLKRSAERAAAFSAISSSPPSKHLLAGTNRFNASKRIPSWNCIARQNSSGSVDDDVLAEASRLYQHIVVGSGRNSNRTSNLSHTYDAGSECDSPEAEDWTRSGGPLMRTNSAQMFTDYVQNLDAVDPEQIRASENDSIVAASSSSHSITVTEGDYLQTGRTHNGFVLNLVRGENLRMNSEPEDSQNESEIPETPESVQLDSPEKDIIDGESSASEDGDAQANLIHDHE
Protein: Insulin-like growth factor 1 receptor (C9EEZ1)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
YVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEME
Protein: KsdD-like steroid dehydrogenase MSMEG_5835 (EC 1.3.99.-) (A0R4H4)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Able to catalyze the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids, but the ketosteroid dehydrogenase activity is low compared to KsdD in the cholesterol degradation process. The low activity could be due to different substrate specificity.
Interaction partners:
- Deacetylase
Sequence:
MADADVIVVGAGLAGLVAACELVERGHSVIIVDQENAANIGGQAFWSFGGLFFVNSPEQRRLGIRDSQELALQDWLGTAGFDRPEDHWPREWAHAYVDFAAGEKRSWLRARGLQTFPLVGWAERGGYDALGHGNSVPRFHITWGTGPALVEIFARRIRDSVRVRFAHRHRVDELIVNAGLVAGVRGSILEPSNAPRGVASSRKVVGDFEFRASAVIVASGGIGGNLELVRKNWPARLGRVPDQLISGVPAHVDGRMIGIAESAGAHVINNDRMWHYTEGITNYDPVWPNHGIRILPGPSSLWLDANGDRLPVPLYPGYDTLGTLEHICRSGQDYTWFILNARIIAKEFALSGQEQNPDLTSRNVRDLLSRVKPGAPAPVQAFVDHGVDFVSATSLRDLVAGMNDLPDVVPLDYAKVAAEVTARDREVANRFTKDGQITAIRAARNYLGDRFTRVVAPHRLTDPKAGPLIAVKLHILTRKTLGGLETDLDSRVLKEDGTTFGGLYAAGEAAGFGGGGVHGYRSLEGTFLGGCIFSGRAAGRGAAADIA
Protein: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (EC 2.4.1.152) (Fucosyltransferase 9) (Fucosyltransferase IX) (Fuc-TIX) (FucT-IX) (Galactoside 3-L-fucosyltransferase) (Q99JB3)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth. Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis. Furthermore, it is capable of synthesizing Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis (By similarity). May also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9Y231}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6P4F1}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O88819}.
Interaction partners:
- Galactoside alpha-
- Galactoside alpha-
- Beta-1,4-galactosyltransferase
- Beta-1,4-galactosyltransferase
- Type 2 lactosamine alpha-2,3-sialyltransferase
- Beta-1,4-galactosyltransferase 3
- Hexosyltransferase
- Beta-1,4-galactosyltransferase 4
- L-Fucosyltransferase
- Alpha-
Sequence:
MTSTSKGILRPFLIVCIILGCFVACLLIYIKPTNSWVFSPMESASSVLKMKNFFSRKTDYFNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTSPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNDKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDFNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN
Protein: CG5276 protein (CG5276-PA) (LD30472p) (Uncharacterized protein, isoform A (EC 3.6.1.42, EC 3.6.1.6)) (Uncharacterized protein, isoform B) (Q9VGN8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- 5'-Nucleotidase C-terminal domain-containing protein
- Uncharacterized protein, isoform C
- 5'-nucleotidase
- 5'-nucleotidase
- apyrase
- Bifunctional purine biosynthesis protein ATIC
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
- UMP-CMP kinase
- Nucleoside diphosphate kinase
Sequence:
MQSPAFAYREHAEHSPRAMYMRDWRSALRTPTYRIGNRTVRFNYHFALLIVCAFVLVLLFYFARQGSHSSSDGYWLRRSYTDARSLDNGGPVVQAYNATYPLTSPMVLRGGVINYRIAMIADLDTSSKVSKGDGSSTWRSYLKKGYLTYTVARSEIQISWDDGAPIVLESAFALKGRGMELSELVTFNGRLLTFDDRTGLIYEIVNDKPIPWVILLDGDGHSAKGFKAEWATVKEQTLYVGSMGKEWTTSAGDFENNNPMYVKAITPSGEVRSLNWVDNFKQLRLQSMQITWPGYMIHESGTWSEERNRWFFLPRRCSKEKYNETKDEHMGCNVLVSADESFTNVETVRLDPENTTPTHGFSSFKFLPGTDDSIIVALKSEELNGKTATFITAFDIAGKTLLPETRIETDYKYEGFEFI
Protein: Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4) (Q6L8H1)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
Sequence:
MGCCGCSGGCGSGCGGCGSGCGGCGSGCGGCGSGCGGCGSGCGGCGSSCCVPICCCKPVCCCVPACSCSSCGSCGGSKGGYGSCGGSKGGCVSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCVSCGGSKGGCGSCGGSKGGCVSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQCSCCKPCCCSSGCGSSCCQSSCCKPCCSSSGCGSSCCQSSCCKPYCCQSSCCKPCCSSSGCGSSCCQSSCCNPCCSQSSCCVPVCCQCKI
Protein: Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) (P51400)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity). Can inhibit cell proliferation and migration and can stimulate exocytosis.
Subcellular location: Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between nucleoli and the nucleoplasm. {ECO:0000250}.
Interaction partners:
- REC114 meiotic recombination protein
Sequence:
MDIEDEENMSSSSIDVKENRNLDNMPPKDSSTPGPGEGIPLSNGGGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLTQPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMAPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGALLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDTAIEVINATTGKDELGRPSRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSFTP
Protein: Protein PIN-LIKES 1 (Auxin efflux carrier-like protein 1) (F4HWB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22504182}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSLTQSAKLHIIHQSIGKITTRLYDTSPFHGDSHCKQRRVKDNCIQFNMNISNVLKCYSEIESFSINQRIRRSISLFLSILRSFYSMRMRLLDLFITSSIPVAKILLITGIGFYLALDQVNILNHDARKQLNNIVFYVFSPSLVASSLSETITYESMVKMWFMPLNVLLTFIIGSFLGWIVIKITKPPSHLRGIIVGCCAAGNLGNMPLIIIPAICNEKGSPFGDPESCEKFGLGYIALSMAIGAIYIWTYVYNLMRMLANPAGETAINSTSSTMPLISPKVEVAEQVGTWGKVKQRVCSVAEKINLRTIFAPSTIAALIALAVGLNPLLRKLLVGNTAPLRVIEDSVSLLGDGAIPVLTLIVGGNLLNGLRGSGINKSVIMGVVVVRYLLLPILGVFIVRGAHYLGLVTSEPLYQFVLLLQYVVPPAMNLGTITQLFGSGESECSVILFWSYALASVSLTVWPTFFMWLVA
Protein: Transcription factor kayak, isoforms A/B/F (AP-1) (Fos-related antigen) (Dfos) (dFra) (P21525)
Organism: Drosophila melanogaster (Fruit fly)
Function: Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:2116361}.
Interaction partners:
- Transcription factor Jra
- Stress-activated protein kinase JNK
- Connector of kinase to AP-1, isoform E
- protein-tyrosine-phosphatase
- Raw, isoform A
- Signal transducer and transcription activator
- Pebbled, isoform A
- Histone deacetylase HDAC1
- Traffic jam, isoform C
- High mobility group protein DSP1
Sequence:
MKNLNGRTHNACYHPYYHQSLHFAQQQQQQQQHHLQQQQQHMQQQQQQQQAPQQQLRHQQRQLPTQPAYQQSQSVAHNAFPLRSSSNNYGHVASSAYAASSGSHNSNNAAAMAAVCQMQNFFNQQQQQQQQLEFNNNCMPINYYQQQQQQHYPSESQSSASGWNPETPGQAQLALTATTCNTTAAATCNTTAAATTSTTATSAAAGSDNNHSDNFAMDASEIATFLANELFLQQLGNFETGQSVLTLTTPTLTPTTTRNIEDTLGHLLSDTQTDRVAGCAGFAVPKVLPNAIDVLGMGIPTGVSSLPLQQTFDLSLGQGSESEDSNASYNDTQMNEEQDTTDTSSAHTDSTSYQAGHIMAGSVNGGGVNNFSNVLAAVSSSRGSASVGSSNANTSNTPARRGGGRRPNRSTNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLEYLLATHRATCQKIRSDMLSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSNDSSNGTITGMDATLNSTGRSNSPLDLKPAANIDSLLMHIKDEPLDGAIDSGSSLDQDGPPPSKRITLPPMSTMPHVHLSTILTPTGASSGSLQTPITSTAPGGFGSAFPVTSNGSSINNINSIGNNMNSPTLNAHNKVPKERPNTLAFQRPLGQMHLTMANNKAGGPTQIQGVPIQTPSTGTFNFDSLMDGGTGLTPVSGPLVPNSSSTNKHPLELPTPTAEPSKLVSL