wanglab/gogpt-training-data huggingface dataset:
Protein: Receptor-like serine/threonine-protein kinase ALE2 (EC 2.7.11.1) (Protein ABNORMAL LEAF SHAPE 2) (Q8RWW0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required during the differentiation of the protoderm into shoots epidermis and cuticle.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Subtilisin-like protease SBT2.4
- SCP1-like small phosphatase 4
- U11/U12 small nuclear ribonucleoprotein 59 kDa protein
- At5g11860
- Jacalin-related lectin 32
- Elongator complex protein 5
- Nucleobase-ascorbate transporter 11
- Nucleobase-ascorbate transporter 6
- Calmodulin binding protein PICBP
Sequence:
MRNFAMLLLLILLLHSLASFPICFARLFPMSLPFTRSKAHQMHFFHPYLNPSVAPTPSPAFSPNPSRIPPLRHKGHHRHRRWHLRRNATAVSPSSHDCQQTCVEPLTSTPFGSPCGCVFPMKVQLLLSVAPFSIFPVTNELEIEVAAGTYLEQSQVKIMGASADSENQGKTVVDINLVPLGEKFDNTTATLIYQRFRHKKVPLNETVFGDYEVTHISYPGIPSSSPNGDVTGDAPGGLPIPINATTFANKSQGIGFRTIAIIALSGFVLILVLVGAISIIVKWKKIGKSSNAVGPALAPSINKRPGAGSMFSSSARSSGSDSLMSSMATCALSVKTFTLSELEKATDRFSAKRVLGEGGFGRVYQGSMEDGTEVAVKLLTRDNQNRDREFIAEVEMLSRLHHRNLVKLIGICIEGRTRCLIYELVHNGSVESHLHEGTLDWDARLKIALGAARGLAYLHEDSNPRVIHRDFKASNVLLEDDFTPKVSDFGLAREATEGSQHISTRVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLTGRRPVDMSQPSGEENLVTWARPLLANREGLEQLVDPALAGTYNFDDMAKVAAIASMCVHQEVSHRPFMGEVVQALKLIYNDADETCGDYCSQKDSSVPDSADFKGDLAPSDSSWWNLTPRLRYGQASSFITMDYSSGPLEDMENRPHSASSIPRVGGLILPNRSGPLRPMRSRRNFFRLRGSMSEHGGPSSSRHLWSGNGDWL
Protein: MAX interactor 1 isoform 3 (A0A0S2Z3Y0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
Protein: U-box domain-containing protein 26 (EC 2.3.2.27) (Plant U-box protein 26) (RING-type E3 ubiquitin transferase PUB26) (Q9FXA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as an E3 ubiquitin ligase.
Interaction partners:
- Calcium-dependent protein kinase 28
- Probable E3 ubiquitin-protein ligase ATL44
- Serine/threonine-protein kinase BIK1
- Probable E3 ubiquitin-protein ligase ATL45
- Serine/threonine-protein kinase 1
- Probable protein phosphatase 2C 38
Sequence:
MPGNLEPLDLGIQIPYHFRCPISLDLMSDPVTISTGQTYDRTSIDSWIAMGNTTCPVTRVALSDFTLIPNHTLRRLIQEWCVANRSNGVERIPTPKQPADPISVRSLLSQASAITGTHVSVRSRAAAIRRLRGLARDSEKNRVLIAGHNAREILVRILFADIETTSLSSELVSESLALLVLLHMTETECEAVASDPSRVGFMTRLLFDSSIEIRVNAAALIEMVLTGAKSMDLKLIISGSDSIFEGVLDLLKNPISSRRALKIGIKAIFALCLVKQTRHLAISAGAPGILIDRLAADFDRCDTERGLATVELLCRLPEGCAAFGEHALTVPLMVKTILRVSDRATEYAAGALLALCTAEERCRDEAAAAGLVTQLLLLVQSDCTERAKRKAQMLLKLLRDSWPDDSTVHSDDFNRSEVAPF
Protein: Collagen type XI alpha 2 chain (A0A8I5ZR92)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MERCSRCHRLLLLLPLVLGLSAAPGWAGAPSVDVLRALRFPSLPDGVRKSKGVCPADVAYRVARPAQLSAPTRQLFPGGFPKDFSLLTVVRTRSGLQAPLLTLYSAQGVQQLGLELGRPVRFLYEDQRGRPQASAQPIFRGLSLADGKWHHVAVAVKGQSVTLIVDCKKRVTRPLPRSVHPVLDTHGVVIFGAHVLDDEVFEGDVQELLIVPGVQAAYQSCGQKDLECEREQRDGPQTQKPHRAQRSPKKEPARLHKPQNQEPQQQPTESLYYDYEPPYYDVMTTETSPDYQYPTPGEEEGVLESSLLPSLEEVAHGPRGLKGEKGEPAVLEPGMFVEGPPGPEGPAGLAGPPGIQGNPGPVGDPGERGPPGRAGLPGSDGPPGPPGTSLMLPFRFGSSGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSPGLKGESGDLGPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGEPGVKGDRGFDGLPGLPGEKGQRGDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPHGPKGSLGPQGEPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPRGKPGLPGMPGSDGLPGHPGKEGPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPGSRGEDGPEGPKGRTGPTGDPGPTGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPAGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGESGPMGERGHPGPPGPPGEQGLPGTAGKDGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNEGPAGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPFGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSPGVQGEPGVKGPRGERGEKGESGQAGEAGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPGEAGPRGQDGAKGSQGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGTPGPEGRQGEKGAKGDPGAVGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLIGLIGPTGEQGEKGDRGLPGPQGSPGQKGETGIPGASGPIGPGGPPGLPGPSGPKGAKGATGPAGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRSVDGSKLMQDEEATPTGGAPGSPAGLEEIFGSLDSLREEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCARDAFRVFCNFTAGGETCVTPRDDVTQFSYVDSEGSPVGVVQLTFLRLLSVSAHQDVSYPCSGVSQDGPLKLRGANEDELSPETSPYVKEFRDGCQTQQGRTVLEVRTPVLEQLPVLDASFSDLGAPTRRGGVLLGPVCFMG
Protein: Evasin P1162 (A0A0K8RDJ1)
Organism: Ixodes ricinus (Common tick) (Acarus ricinus)
Function: Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5 and CXCL8.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MEVKTFAFLQIAVCIAIGIELICAGTNALNDEELFTVDYCGTNCTQQPNGSWTTCPGNCSCYHEDGKTDGFCLSTEYTDFTQFPNLTSEEMDAATPRPE
Protein: SH3 domain-containing GRB2-like protein (G5ECK4)
Organism: Caenorhabditis elegans
Interaction partners:
- Amphiphysin
- Cell division control protein 42 homolog
- C3H1-type domain-containing protein
- Ras-related protein ced-10
- Dynamin
- DH domain-containing protein
Sequence:
MAHLSWVRISNATQDPETRCSVAQDQIVKVVREEGDWCHIQTIEGVSGRVPRVLTLPIVDPKRQPDEQVYCSIEAYTSIRSDDLSFAEFSIFVAKPSRSNPGYLDGFLVNDNAVQIGRRGLLPEAHLVNLHVSAESPMKPSFTTDFSEADVRFRTPATAPKAATSNYAVSPYARAVYDFQGEFENELSFSADEIISLRRRIDAEWLEGSIGSARVGIFPTSFVQIIVDLPDDDTTSLQNNRRSTTTENDGIGFANVRHAFSGRQGDELTVNAGDTVRVLRMVNDEWVMCKDPDTEKTGIVPVGFLEVYLDEEDDDNQSSNAMRRGTGGTSDFTFGSSNNRSSFISNAESSSDWRPPAGRTNTDWATFEAVPPAAPASKPAQNWATFGEEWIAPVQLAKTSAPARPPPPKQSSIQSPINDIGNVADMFGMTDTPKPSNPAIQSAGSDFEIGLISATEGASNDEDKRCRIIEELISSELQFISDINSYTEAVDGTPLLNQKQKVILKNGCAQIVQLSANLVQLLTNEQIKPQDAQLIGACFLQLRKPFAQTYGFYFRNIEHINALTNSAKHEKTMESALQDIVKRMRESGSVVIDGPTAVSRPIQRATKYPLFLNEIVKLTPLVHTDHPKLTEAIKQMSNLGQKMNESKRRKELTQKYMSDDKQTFGEMLSKMTFHSLKKKSNRFTYRMGSSLGVVKLLRDTDFDRLVCELDSAERRLVRFNYMMVIYRKKMFHETRVLMHKKVVEPRKKHLSSSEIDLQLQPFNHAIKTWASEANVRIRDEIVKALRSIPKRLIKKRNDKLMDYEASRTKEKGLGKRDFAEIQKDYEALNTQVKQQLPKVTEYLTTVLATSMRTVSEQDKALMETLRKLFNDAKSKAAEDQSKAARSLIIPTTICFVDYYDQDRMKPLQKIANKAIQNMKQRARSVSPKGSKPGTSSSSTTVTESPWATAPTFIPPAATEILPTITEGSTSTHKFRNQNATERNTILEKATAKGRLGDIFVATSHYPQDSGMLKIALAEGKLLIVKQNDLVLAVNREVPSMWLCYNGYYNAMLPSSILKPYTSIEKGVDVAKSAQFTGQTAQVVAPQAPVQNQNAPKSQNLIDLEDLFGGPPQPAAAAHPTSLAFAPAQQQQNFATFDFTSSPLQPTSLVPQAPAQNAQFDWNMAAKTLPLAPAPPMQVSQQAPQQQQQVQEGAGGANYNLDLDNLFSGLSTIDWGAKTSTAPPPLYSNTPLDTATSPPVSAFRGVDFQTGVFNPNSLPDEAPPPLPVIVNPTRDDPFSTNFVPNFAAAAPATSPFGTASNSSVQFPVSFDEAPSSMGSLGLPTGSMNQKRSASAAAQPTNVWPTTSMMSRSDSPQPLIPSRPEPAVKNVYPSLNDGSARAPTFATTFPSQANQSLPMYSAVPNDTMSMNYAMPPMYDTTPQSPRVQLQQQHQPAAYDTPPTIAPIYDQLPNESPASTAIRPVLCQVKVDYDFLPQGSNQVEVKEGEVIGVLQRTDDDGNPEWLLIKRDSGKVGYVPAAYCRPV
Protein: Ras GTPase activation domain-containing protein (Q54Q13)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MTELNSNNNNTENIENQQNNNNNTNNAVVFGSKYKHNLRSTVSIERTPNKYSDIIDLLLSPDLEIVSSLCSTTLVRETVPNSVHISEYLIVFFEYHCNLKSSYILKWAIDKEIENTSNSATLFRGLSTATRLISAFYKRVGESYLKYLLQPFVIDLCSRNFSFEIDPEKAGKGVNIQANLEKLITITQQLLDKILDSVDQCPLPIRQILNHTQEKVEKRFKSMKTTVVGGFIFLRFICPAIVAPEAFGLIPREEEPTSETRRGLVLVSKLLQNLANEMPFGSGIKEEYMSYLNDFITNNSTRIHVFFDSLAQDPTQQQQQIQPLQQQQQQQQQPSSTSTNLNATNNNNSNCSSNHTSSNNIGSGVSTPKLTSTPLGSVQQSSGNHNEDSNSNNNNNTTNTTTTTNNNNNNNINNNNNNNNNNSSNNKLNSIIMTEDSITDNLNVLMNQIIENREKIENYIQENGNIDSSSDIIKRLDTSLQAAKQKASYFNFWGRGKDKSNISGSGGGGGGSSGGPTTSNGKLKKSPSAGVVSNSNHIQQLQEKEREKEREKDKDKEKDKDKEKDKDKEKHASQKKLQLSQSQHTLVLDGISTNGGNINNNSNNNKSLLKNQGQLSEELEMRDQKEVDNLNLMAENSRLKKELEDAKSRNNLLRKLREELEREKSEKKELKLLIKRCNDRLKSLDDQLDLINDLQPWVDDNPPSGNHDLQSLIEETLGVGGSLSNRKKSNSSLGISKVRGYDTAPTTPTNTILSSSTTNIPSITNAMINHNNINVNICAINGSKDTTSSSTLISATSTPTISIVDNCTTATSSLQPSPQPNSQSVNLNHSTNYIPHLDVSCDSNNSSTTSSFYNNQNNLNSNNNIKKSSTNQSISESLMSEISEADESKSGSNISISSATIHSNSGGNNNNNNNNNNNSGSNGKGSNSTSGLSRKNSTTSEMSMADPTNYENQNLIIQTVVEGGEILDDSACDLLEFLKEVASKQELQKSKERQRLQEEKENKAKNSVFFKFSSKFSSKRRSKDGKNQPLSPPLSSQNSQQEKDSPNSGAALSLNN
Protein: PslD (Q9I1N5)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004571}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004571}.
Interaction partners:
- PslE
- PslA
- Alginate biosynthesis protein AlgA
- PslF
- PslH
- PslG
- PslJ
- dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase
- PslI
- PslL
Sequence:
MKRTLLMLAMLALAACNTPARIPAPDSDTVDSGKRALEELARLPPAMERVRVGDTLRIVRDAGEMPTLSAFNVATIYELTLYTVLNDGSIYYPFIGRIQAAHRTPQEIANELTTKLAPIYREPRVTVNINQAPGNTVFVGGAVRNPSAVPIPAANNMEQAILGAGGILPVGDARRVALMREDSEGRYHAYFLDFSQLMKIGPEGRKPLAMQRGDIVFVPKSMVGDRIEGVDVYLNQLLPFAKSIGVGVSYTVNNDR
Protein: Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) (P62256)
Organism: Homo sapiens (Human)
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.
Interaction partners:
- Ubiquitin-like modifier-activating enzyme 1
- NEDD8-activating enzyme E1 catalytic subunit
- WD repeat-containing protein 26
- RING-type E3 ubiquitin transferase
- Tripartite motif-containing protein 72
- Armadillo repeat-containing protein 8
- E3 ubiquitin-protein ligase MARCHF4
- E3 ubiquitin-protein ligase MARCHF1
- E3 ubiquitin-protein ligase MARCHF9
- Ubiquitin-like modifier-activating enzyme 7
Sequence:
MSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPDKYPFKSPSIGFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHRPEEYKQKIKEYIQKYATEEALKEQEEGTGDSSSESSMSDFSEDEAQDMEL
Protein: Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase) (P0A9Q9)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
Interaction partners:
- Bifunctional aspartokinase/homoserine dehydrogenase 2
- Bifunctional aspartokinase/homoserine dehydrogenase 1
- Lysine-sensitive aspartokinase 3
- 4-hydroxy-tetrahydrodipicolinate synthase
- Homoserine kinase
- Threonine synthase
- 4-hydroxy-tetrahydrodipicolinate reductase
- 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
- 1,4-alpha-glucan branching enzyme GlgB
- Diaminopimelate epimerase
Sequence:
MKNVGFIGWRGMVGSVLMQRMVEERDFDAIRPVFFSTSQLGQAAPSFGGTTGTLQDAFDLEALKALDIIVTCQGGDYTNEIYPKLRESGWQGYWIDAASSLRMKDDAIIILDPVNQDVITDGLNNGIRTFVGGNCTVSLMLMSLGGLFANDLVDWVSVATYQAASGGGARHMRELLTQMGHLYGHVADELATPSSAILDIERKVTTLTRSGELPVDNFGVPLAGSLIPWIDKQLDNGQSREEWKGQAETNKILNTSSVIPVDGLCVRVGALRCHSQAFTIKLKKDVSIPTVEELLAAHNPWAKVVPNDREITMRELTPAAVTGTLTTPVGRLRKLNMGPEFLSAFTVGDQLLWGAAEPLRRMLRQLA
Protein: 40S ribosomal protein S7 (Q38FD9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Small ribosomal subunit protein uS4
- 40S ribosomal protein S15, putative
- Ribosomal protein S19, putative
- 40S ribosomal protein S27, putative
- 40S ribosomal protein S4
- 40S ribosomal protein S15a, putative
- 40S ribosomal protein S5, putative
- 40S ribosomal protein S13, putative
- 40S ribosomal protein S25
- 40S ribosomal protein S26
Sequence:
MSAQPHLRKLRKLKRANPSQEEESVARVLFELEGSHKTLRAQLPRFHINTVRTSSSPRHKKTAMIILYPLRFIMLVRKIQRTLTAELEKRFPGNIVVLVAQRKITKRPNDVYKLQQVQRSRTSVAVFENILNDLIYPCDVVGRRWRYRTDGSKLMKVFLDARDRKRVESRLPLLAHVYKLLTHRTVTFGFMWNPKLQQVSSR
Protein: Cation-transporting ATPase 13A3 (D3YT44)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MYPKPVDFRFTKDLFKFILFLACISGCGFIYTIIVMIMRGNTLRRIIVRSLDIITITVPPALPAAMSVGIINAQLRLKKKEIFCISPSTINTCGAINVVCFDKTGTLTEDGLDFHVVRPVMSAVNQEIQKVKLEKSNRTEFMGEMTELTSRNGLPFDGDLVKAIATCHSLTRINGVLHGDPLDLILFQKTGWTMEEGIEGDIEEETQRFDNVQPSIIKPTDDKSAEYSVIRQFTFSSSLQRMSVIVFDPREDRPDNMMLYSKGSPEMILSLCDPNTVPEDYLLQVNSYAQHGFRLIAVARRPLDLNFNKASKVKRDAVECDLEMLGLIVMENRVKPVTLGVINQLNRANIRTVMVTGDNLLTGLSVARECGIIRPSKRAFLVEHVPGELDEYGRTKIFVKQSVSSSDEVIEDDASVSISMCSSTWKGSSEGDGFSPTNTEVETPNPVTADSLGHLIASSYHLAISGPTFAVIVHEYPELVDQLCSVCDVFARMAPDQKQSLVEQLQQIDYTVAMCGDGANDCAALKAAHAGISLSDAEASIAAPFTSKVPDIRCVPTVISEGRAALVTSFGIFKYMAGYSLTQFVTVMHLYWISNILTDGQFMYIDMFLITMFALLFGNTPAFYRLAHTPPPTRLLSIASMTSVVGQLIIIGVVQFIVFFSTSQQPWFTPYQPPVDDEVEDKRSMQGTALFCVSMFQYIILALVYSKGPPFRGNLWSNKPMCALTIFATLLCLFIVIWPTELVLKTLGNVELPSLTFRIFIVIVGAVNAAVSYGFETLFVDFFLLGYWERYKKKRSIEAIIDYVPTTNSDHIRRPSINGVTSSRTESTLLSAEGQQLHMTTSKNGKGGENPHSSALFERLISRIGGEPTWLTNPIPPHSLSEPEEPEKLERTY
Protein: DNA polymerase epsilon catalytic subunit (EC 2.7.7.7) (D3Z8X4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365029}.
Interaction partners:
- DNA polymerase epsilon subunit
- DNA polymerase delta catalytic subunit
- DNA replication licensing factor MCM2
- DNA polymerase epsilon subunit 4
- DNA helicase
- DNA polymerase alpha catalytic subunit
- DNA polymerase epsilon subunit 3
- DNA replication licensing factor MCM3
- Cell division cycle 45
- DNA replication licensing factor MCM4
Sequence:
MVLRNSGRRHPEPGADSEGSRDDGPSSSVSALKRLERSQWTDKMDLRFGFERLKEPGERTGWLINMHPTEILDEDKRLVSAVDYYFIQDDGSRFKVALPYKPYFYIAARKGCDREVSSFLSKKFQGKIAKLENVPKEDLDLPNHLVGLKRSYIKLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTTMLSSILQGGSLITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLRIHVAHWYNVRFRGNAFPVEIARRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEVHLIQRWFEHIQETKPTIMVTYNGDFFDWPFVEARAAIHGLSMYQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDAETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTMRHAIEEEEKVPVEQATNFQEVCEQIKTKLTSLKDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAIVDEATCAACDFNKPGATCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHMTKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDASEVKRCKNMEILYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVIKTTNVKKPKLTISYPGAMLNIMVKEGFTNHQYQELTEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYASVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRTILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDIYKQKKISELFVLEGKRQIVMAQASENSLSLCTPDMEDFGLTKPYHSTVPVATKRKRVWESQKESQDITLTVPWQEVLGQPPSLGTTQEEWLVWLQFHKKKWQLQAQQRLARRKKQRLESAEDMPRLGAIREGPATGLGSFLRRTARSIMDLPWQIIQISETRQAGLFRLWAIIGSDLHCIKLSIPRVFYVNQRVAKAEDGPSYRKVNRALPRSNIVYNLYEYSVPEDMYQEHINEINTELSAPDIEGVYETQVPLLFRALVQLGCVCVVNKQLARQLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHTQGHKALFGVFIPSQRRASVFVLDTVRSNQMPGLSALYSAEHSLLLDKVGPNLLPPPKHTFEVRAETNLKTICRAIQRFLLAYKEERRGPTLIAIQSSWELCRLTSEIPVLEEFPLVPVRVADKISYAVLDWQRHGARRMIRHYLNLDICLSQAFEMSRYFHIPVGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTSRPDLGGKEADDNRLVMEFDDRATVEINNSGCYSTVCVELDIQNLAVNTILQSHHVNDMEGAGSMGISFDVIQQASLEDMVTGNQAASALASYDETALCSSTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLQSPCSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRIEDALAYVEYITNSIHSKEIFHSLTISFSRCWEFLLWMDPSNYGGIKGKVPSSIHCGQVREQDSQTREETEDEEDNEKDEEEEEDMGQSEVEDLLENNWNILQFLPQAASCQSYFLMIVSAYIVAVYQSMKDELRHSAPGSTPVKRKGASQFSQEAEGAAGALPGMITFSQDYVANELTQTFFTITQKIQKKVTGSRNTAEPSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCHSYVLPEVICHSCNFCRDLDLCKDSSFSQDGAILPQWLCSNCQAPYDSSAIESALVEALQRKLMAFTLQDLVCLKCRGMKETHMPVYCGCAGDFVLTIHTEVFMEQIRIFQNIAKYYNMSYLQEAIEWLLQTSPVSNF
Protein: Homeobox protein Nkx-2.5 (cNKx-2.5) (Homeobox protein NK-2 homolog E) (Q90788)
Organism: Gallus gallus (Chicken)
Function: Transcription factor required for the development of the heart and the spleen. Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P42582}.
Interaction partners:
- T-box transcription factor TBX5
- Transcription factor GATA-4
- Myocyte enhancer factor 2C.
- Insulin gene enhancer protein ISL-1
- Transcription factor GATA-5
- T-box transcription factor TBX20
- Heart- and neural crest derivatives-expressed protein 2
- Transcription factor GATA-6
- T-box transcription factor TBX3
- Serum response factor
Sequence:
MFPSPVTTTPFSVKDILNLEQQQQGGLAPMELSSPSCMLATFKQEAFGSEPPALPELPEPPPAKPPAAFPGPYYVKSYGEMDTAKDSKADKKELCALHKSLEQEKRELEDPERPRQRKRRKPRVLFSQAQVYELERRFKQQKYLSAPERDHLANVLKLTSTQVKIWFQNRRYKCKRQRQDQTLEMVGIPPPRRIAVPVLVRDGKPCLGESSPYSSPYNVSINPYSYNAYPAYPNYNSPACNANYNCSYPAVQPVQPSAAGNNFMNFSVGDLNSVQPPIPQGNAGISTLHGIRAW
Protein: Polyadenylate-binding protein (PABP) (O96971)
Organism: Trypanosoma brucei
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU362004}.
Interaction partners:
Sequence:
MAAFAAASPSIWVGGLDPNLNEQKLYDHFVRVGPVASVRVCVDSVTQKSLGYGYVNFQNPADAEKALDQAGVKLGTKHIRIAKIQRDPSKRRSGVTNIIVKKLPPTVDTYALKEMFSKYGRLTAIGLATDEKGESRGYARISYEKEESAVDAVRELNGVSIDDCAITVERYQPHHREEQLKQYTNLYVKNLDPSVDDEKLKEVFSPFGEVTSAKVRDLAGRPTVGFGYVAYATHEAAAKAVEELDDKESPLAKEGMKLSVCRFRSREERKRERERLRRERQQQHSKYPNLYVKNFDDTVTSERLKALFDPFGETVSVSVMMDKATKVSRCFGFVSFKEQSSAAQAIQELHGSTALGPRPLFVSYALRKDARRQTLEDMRNKQPRMRQPPMGGLMGGMMGPQLSFMNPPAMFNGMHFMNTRMPMMPSTMGMGGPMRPMGPTPMNQVRARPGPQRPPMQSMMAPQQQSHPQIPQPPVAQGQNLSTVLASMTPDQQKNVLGERLYNYIVRNNPSFAAKVTGMLLEMDNSEILNLLDNHSLLDTKVQEALDVLNRHIGM
Protein: Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 4.3.2.7) (Blocks Notch protein) (Botch) (Cation transport regulator-like protein 1) (Q8R3J5)
Organism: Mus musculus (Mouse)
Function: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (By similarity). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BUX1}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:22445366}.
Interaction partners:
- Tribbles homolog 3
- Phospholipid hydroperoxide glutathione peroxidase GPX4
- Gamma-glutamylcyclotransferase
- 5-oxoprolinase
- Cyclic AMP-dependent transcription factor ATF-4
- Glutathione hydrolase 6
- Glutathione synthetase
- Glutathione peroxidase 3
- Glutathione peroxidase 1
- Glutathione peroxidase 2
Sequence:
MKQESASQSTPPPSLSPAPSSAQPSWGDGDPQALWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDREGCTWGVAYQVRGEQVNEALKYLNVREAVLGGYDTKEVTFYPQDTPDQPLTALAYVATPQNPGYLGPAPEEVIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQDEHLEAIVDAVGTLLPCSYLPEQPLALT
Protein: PDZ domain-containing protein C1685.05 (O74325)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Sexual differentiation process putative subtilase-type proteinase isp6
- Sterol regulatory element-binding protein cleavage-activating protein
Sequence:
MTPVSSDYRPNHIFLPKFRPDKITSECNTPQQQNVIAEGLYNVSEPFPIRNTDEERYLDTKEIHHTWDNTIKNVVRSIVSIKGSALRSFDTESAGSFCATGFVVNKTLGLILSNRHVVSPGPISARASFINYEEIDIYPIYRDPVHDFGFFRYDPSSIRFHDVTEISLSPESAKVGIDIRIIGNDAGEKLSILSSTLARLDRPAPNYGIDNYNDFNTFYYQAASGTSGGSSGSPVLDISGAAVALNSGGSNSSASSFYLPLDRVVRALRCIENNTPITRGTLLTEFLHWSYDELSRIGLPREFEYDCRTRVPSSTGLLVVSRVLRNSEVSKALEPGDILIAFKTDSHKSTYIVDFVSLFEVLDEMVGKTIELHVYRPKRGFLTFQLTVQDLHNVTPSRFLEVGGAVLHDLSYQLARSYQFSLNSGTYVASSGMLNWSSGTRDFLVTRLANKPTPTLDAFIDVLVQLTDNARVPMHFRVLGKYEEEFTIVTVDRHFFLASIFSRNDEKGTWDRQSLPPPQPSISRRPSVIPRPQEGSKSMEAIQNALVLVHCRMPYSINGFSSTKLYSGTGVIVSVVPPLIVVDRSVIPVDICDIRLTFQSMSAMGHLTFLDNRIAVVSCDYLPSNSVQLNFVADFLRTGDECTLAALDEDLQLLTKKTTVRSVSVVETERSSPPRFRYVNCEVISLMDSLASTGGLVFREVGDDREIVALWISVVHQDVGGKDYTTKYGLSMSYILPVLERLKLPPSARAQHVPTTAGVEWSHITLAGASTLGLSQTRSSEFYMKSRENGTIPRPLYVISHLRPLLHKTSLGVGDILLEVNGKMITRLSDLHEFETESEIKAVILRDGIEMEITIPLYPEYPTFSSRAICWMGAIIHPTHSSVFEQVEPDVDLPGPEGVYVGSILYGSPALNMLRAAHWIVAVDGHDINTFDDFYHMLLEKPTDTFVQVKQMNRRGATSIVSVRPDPLFWPTCIIERDSNGRWCTKHLQRKTKEVCS
Protein: Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450-HP) (P13584)
Organism: Homo sapiens (Human)
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
Sequence:
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
Protein: 2-keto-3-deoxygluconate permease (KDG permease) (3-deoxy-2-oxo-D-gluconate-transport system) (P0A712)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the proton-dependent uptake of 2-keto-3-deoxygluconate (KDG) into the cell. Expression of this specific KDG-uptake system may allow growth with KDG as the sole carbon source. Can also transport D-glucuronate.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:6094479}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- HTH-type transcriptional regulator KdgR
- 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
- 2-dehydro-3-deoxygluconokinase
- 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
- KHG/KDPG aldolase
Sequence:
MQIKRSIEKIPGGMMLVPLFLGALCHTFSPGAGKYFGSFTNGMITGTVPILAVWFFCMGASIKLSATGTVLRKSGTLVVTKIAVAWVVAAIASRIIPEHGVEVGFFAGLSTLALVAAMDMTNGGLYASIMQQYGTKEEAGAFVLMSLESGPLMTMIILGTAGIASFEPHVFVGAVLPFLVGFALGNLDPELREFFSKAVQTLIPFFAFALGNTIDLTVIAQTGLLGILLGVAVIIVTGIPLIIADKLIGGGDGTAGIAASSSAGAAVATPVLIAEMVPAFKPMAPAATSLVATAVIVTSILVPILTSIWSRKVKARAAKIEILGTVK
Protein: C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) (P21730)
Organism: Homo sapiens (Human)
Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12464600, ECO:0000269|PubMed:29300009}; Multi-pass membrane protein {ECO:0000269|PubMed:29300009}. Cytoplasmic vesicle {ECO:0000269|PubMed:12464600}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269|PubMed:12464600}.
Interaction partners:
- Complement C5
- C3a anaphylatoxin chemotactic receptor
- Small ribosomal subunit protein eS19
- Complement C4-A
- Complement C3
- Toll-like receptor 2
- C-C chemokine receptor type 5
- Guanine nucleotide-binding protein G
- fMet-Leu-Phe receptor
- Integrin alpha-M
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV