wanglab/gogpt-training-data huggingface dataset:
Protein: Putative 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) (O18229)
Organism: Caenorhabditis elegans
Function: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Subcellular location: Nucleus {ECO:0000269|PubMed:32338603}. Note=Localizes to the nucleus of germ cells. {ECO:0000269|PubMed:32338603}.
Interaction partners:
- Glucose-6-phosphate 1-dehydrogenase
- 6-phosphogluconate dehydrogenase, decarboxylating
- Gluconokinase
- N-acetylglucosamine-6-phosphate deacetylase
- Transaldolase
- transketolase
- Probable-ribose 5-phosphate isomerase
- Ribulose-phosphate 3-epimerase
- Ribokinase
- Glucose-6-phosphate isomerase
Sequence:
MCLVNEFVSNSNMKPALNVSGDEKELILQLRRYLEEKLTYLLDQNGTVSIGVSGGSMPRVFSKAILSLPQEQLNWKRIRIFMVDERNVDLDSEESNQGEYLRLFPNELRDVFVPMQIFKDPCLTAQHYEISLRKYLLPEQLNNTARFDILFLGVGPDGHTASIFPGKERLEKITELNWVSVITDSPKPPPSRITLTLQTLQHAKNVAFIICGKQKAEIVRGICDRDQKYPAAQARPFNDKLTLFLDEDAATGVPDRDSSDSDSPPPFDG
Protein: ATPase phospholipid transporting 8A1 (D3ZJK8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Phospholipid-transporting ATPase
- Cell cycle control protein 50A
- Cell cycle control protein
- Phospholipid-transporting ATPase
- Phospholipid-transporting ATPase
- Phospholipid-transporting ATPase
- Phospholipid-transporting ATPase
- Phospholipid-transporting ATPase
- Phospholipid-transporting ATPase
- Phospholipid-transporting ATPase
Sequence:
MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNVITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIF
Protein: Germacrene A synthase (EC 4.2.3.90) (5-epi-alpha-selinene synthase) (8a-epi-alpha-selinene synthase) (Terpene synthase) (B2J4A4)
Organism: Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Function: Catalyzes the cyclization of farnesyl diphosphate (FPP) to the sesquiterpene germacrene A.
Interaction partners:
- Terpene synthase
- Squalene/phytoene synthase
- dimethylallyltranstransferase
- Isoprenyl transferase
- Isoprenyl transferase
- Dyp-type peroxidase family
Sequence:
MNQLLCPGLYCPFPSQTNKYVDVLEEYSLEWVLRFNLLANESAYKRFCKSKFFFLAASAYPDSKFEELKITHDWLSWVFIWDDQCDLSELKKQPEVLNNFHQRYLEILNGAELTSQDTLFSHALIDLRKRTLQRASIKWFNYFISYLEDYFYGCVQEATNRAKGIVPDLDTYIMIRRSSVGVYAVLALSEFCNQFIIPDVLRNHHLVKKLELITTDIIAWSNDIFSASREIASGDVHNLIFVLHYHKKISLEKAIEQVVKIHNEEVHSLIKVESSLSFFSEELDVEITKYISGMHSWIRGNLDWCYESYRYHNLERLELTEFK
Protein: Phosphoglucosamine mutase (EC 5.4.2.10) (Q9HV50)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
Interaction partners:
- Bifunctional protein GlmU
- Glutamine--fructose-6-phosphate aminotransferase
- Dihydropteroate synthase
- Probable aminotransferase
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase
- Probable N-acetylglucosamine-6-phosphate deacetylase
- UDP-N-acetylmuramate--L-alanine ligase
- ATP-dependent zinc metalloprotease FtsH
- UTP--glucose-1-phosphate uridylyltransferase
- Triosephosphate isomerase
Sequence:
MSRKYFGTDGIRGRVGEFPITPDFVLKLGWAVGMAFRRQGNCRVLIGKDTRSSGYMFESAFEAGLSASGADTLLLGPMPTPGIAYLTRTFHAEAGVVISASHNPHDDNGIKFFSGQGTKLPDDVELMIEELLDAPMTVVESARLGKVSRINDAAGRYIEFCKSSVPTSTDFNGLKVVLDCANGATYKIAPSVFRELGAEVTVLAASPNGLNINDKCGSTHLDGLQAAVVEHHADLGIAFDGDGDRVMMVDHTGAVVDGDELLFLIARDLQESGRLQGGVVGTLMSNLGLELALQELHIPFVRAKVGDRYVMAELLARNWMLGGENSGHIVCCQNTTTGDAIIAALQVLMALKHRGQTLAEARQGIRKCPQVLINVRFKGENDPLEHPSVKEASVRVTEQMGGRGRVLLRKSGTEPLVRVMVEGDEEASVRAHAEQLAKIVSEVCA
Protein: PR domain zinc finger protein 13 (EC 2.1.1.-) (PR domain-containing protein 13) (E9PZZ1)
Organism: Mus musculus (Mouse)
Function: May be involved in transcriptional regulation. Is required for the differentiation of Kiss1-expressing neurons in the arcuate (Arc) nucleus of the hypothalamus. Is a critical regulator of GABAergic cell fate in the cerebellum, required for normal postnatal cerebellar development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MPAHVTPRTEDARRGAGPSSACGCSWFCHLRPVEDPASPSVCLAAVATMHGTSRTSATSVNADCCIPAGLRLGPVPGTFKLGKYLSDRREPGPKKKVRMVRGELVDESGGSPLEWIGLIRAARNPQEQTLEAIADLPGGQIFYRALRDVQPGEELTVWYSNSLAQWFDIPTTATPTHDEKGEERYICWYCWRTFRYPNSLKAHLRFHCVLSGGGGRAFLPQEHAARPGASPVAEGLGLPPKPTVPDLTAPVQAIALRPQAPAAQLAQACGARESIKREASLAPLATSPPPGKWGTPKKGKEQPDRAHSQFLGIVGGSSGGGGGLPFYPGVRSAFKPAGLARAAAQSDPYREEGGGKGPGLALGRLLGGGRAGGRPGSGESPAGHHHHHHHAHHHHHHHPKCLLAGEPPPAGLPCPGALRAFPLLAGHPEEASAFKHVERAPPAAATTSLPSARYAALPAPGLPVERCALQPLDGGSLKAYPGGGGGGECSPLPAVMPAFTVYSGDLLYGPPAAYYPLKLHLGGLLKYPESISYLSGPAAAAAAAAAAAAAAAAIGPAELGSLASIDREIAMHTQQLSEMAAGKSRARLDSGTLPPAVVAATGPGGGGGGGSAAGKPKTGHLCLYCGKLYSRKYGLKIHMRTHTGYKPLKCKVCLRPFGDPSNLNKHIRLHAEGNTPYRCEFCGKVLVRRRDLERHVKSRHPGQSLMAKAGDGPGPEPSYALEPGDPKSEDSDVDVCFTDDQSDPEAGGRGEHDS
Protein: Brevinin-2SN2 (E7EKH5)
Organism: Sylvirana spinulosa (Fine-spined frog) (Hylarana spinulosa)
Function: Antimicrobial peptide. Active against some Gram-negative and a variety of Gram-positive bacterial strains. Active against fungus C.glabrata 090902 but not against C.albicans ATCC 10231. Shows hemolytic activity against human erythrocytes.
Subcellular location: Secreted {ECO:0000305|PubMed:24055160}.
Interaction partners:
Sequence:
MFTLKKPLLFLFFLGTISLSFCEEERGADEDDGGEMTEEEKRGVLDTLKNVAIGVAKGAGTGVLKALLCQLDKSC
Protein: Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) (Q96EQ0)
Organism: Homo sapiens (Human)
Function: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
Interaction partners:
- Golgi to ER traffic protein 4 homolog
- Ubiquitin-like protein 4A
- ATPase GET3
Sequence:
MSSIKHLVYAVIRFLREQSQMDTYTSDEQESLEVAIQCLETVFKISPEDTHLAVSQPLTEMFTSSFCKNDVLPLSNSVPEDVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLREVSSPTGTGLSFDMASLINNPAFISMAASLMQNPQVQQLMSGMMTNAIGGPAAGVGGLTDLSSLIQAGQQFAQQIQQQNPELIEQLRNHIRSRSFSSSAEEHS
Protein: Uncharacterized protein (Q3UWU4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
RLDRTPSHASVSVCVSNWTLPSHCLTLIYSCYITRCCVAVYQCTESIQACIAVCYLHTRPYSCLSRFKATDQPLPFVAGQHHFSMSADASPRVMTEVVENGYILFILCFVLNLKSNLPLTLCS
Protein: Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) (Q21230)
Organism: Caenorhabditis elegans
Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56329}.
Interaction partners:
- Translation initiation factor eIF2B subunit gamma
- Eukaryotic translation initiation factor 2 subunit 1
- protein-synthesizing GTPase
- Translation initiation factor eIF2B subunit epsilon
- Translation initiation factor eIF2B subunit delta
- Eukaryotic translation initiation factor 5
- Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit beta
- SUI1 domain-containing protein
- Eukaryotic translation initiation factor 3 subunit C
Sequence:
MADDLGLDLGKKKKSKKVIKIDGDDAPVETGVEAVEDGLGELNLGAKKKKKTPKTAGEEVVEEKVPTLEIGIGAQNLIDAKGAWPDYTYEEALTLVYQVMKDKNPDFAGDKKKFAIKLPEVARAGSKKTAFSNFLEICRLMKRQDKHVLQFLLAELGTTGSIDGSNCLIVKGRWQQKQFESVLRKYIKEYVMCHTCKSPETQLTKDTRLFFLQCTNCGSRCSVTAIKSGFKAVVGKRAAIRRAEEATAGK
Protein: Defective proboscis extension response 17, isoform A (Defective proboscis extension response 17, isoform D) (FI20195p1) (Q9VGD3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Dpr-interacting protein gamma
Sequence:
MPQTSPNWRQADNERTKGAVSVIAARNWATGTATQDWSQKSSSSWSSTSRRTGISRTRTRPATLTTEMTVAGRAERAGVGAPWCRRFFHTSPLASWLRISFVLLVLPALGFGIQVVTCSNPELGASAPDPVDLTWGGKNTEGQLTTATRSTLPDSPMTTQNDLITTASNLATAKKPATAASEAVVDTAETAETAPPTEATSSWSSTAVARGMSSADGAGEAIATSQSAQIGLTTQATVRQTEAQTASTATQAAAATSAATSAAIASAAAATETAAEMLISTIYPASTETDLHNSIERVEGQRGKMANAFHPGVPDSLTKGFSIPTFLPPFPVFAAADLPAYRAAADAAEAAKLAAEAAAQAAAAKTSSEAVTMSPEEQRRQMFNEQHSYLAAHRDGGDGAGSAVRRNLTMPVLNITAQMGNHAYMPCQIHRLSDKPVSWVRMRDNHIISVDETTFIADERFQSIYQEDHDYTWSLQIKYVEPSDAGWYECQMATEPKLSAKVHLQIVKPKTELIGDQSRFVKAGSKVALHCIVRGTLDPPKYIIWFRGQKKISDSDERTGWYTQLDRNIFGTVGDNQNTIGSLIIPLVRKEDSGNYTCQPSNSVSVSVDLHVLSGEYSASAIMSTAARTTKGGRSTCHSTLGLLGILGLLWAMQGAMHTPPTQT
Protein: Binding protein (B3H6W5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MCLTTSEPPFPDTDTPTMRSASYHIKHKSKTQTHLRILNLTSRRRRLLKEQKEMEMRNLKLFVENQSIIRENEALKKKALLLHHENNALFALLHPKYSPVSTSLLQ
Protein: Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) (TRH-degrading ectoenzyme) (EC 3.4.19.6) (Pyroglutamyl-peptidase II) (PAP-II) (TRH-specific aminopeptidase) (Thyroliberinase) (Q10836)
Organism: Rattus norvegicus (Rat)
Function: Specific inactivation of TRH after its release.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- Pro-thyrotropin-releasing hormone
Sequence:
MALDGERGEQEEEKKKKKKKKKRKKKEEEGAEKSSSPFAATMGEDDAALRASGRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSIVALLAVTMLAVLLSLRFDECGASAAMPGTDGGLGGFPERGGNSSYPGSARRNHHAGEESSQREIGEVGTAGTPSAHPPSEEEQEQWQPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACQNATRYVVLHASRVAVEKVQVAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYVIHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDIDKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNMTAENRILITQQHFIYDIGAKTKALQLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWILGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYSKLGWPKNNFNGSVVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKSYDGVASASFSRAVETVEANVRWKRLYQDELFQWLGKAMRH
Protein: Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (PGM-complementing protein 1) (P38628)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. Also has phosphoglucomutase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Glucosamine 6-phosphate N-acetyltransferase
- UDP-N-acetylglucosamine pyrophosphorylase
- Glutamine--fructose-6-phosphate aminotransferase
- Probable glutamine amidotransferase DUG3
- Phosphoglucomutase 1
- UTP--glucose-1-phosphate uridylyltransferase
- Phosphoribomutase
- Mannose-1-phosphate guanyltransferase
- Glucose-6-phosphate isomerase
- Mannose-6-phosphate isomerase
Sequence:
MKVDYEQLCKLYDDTCRTKNVQFSYGTAGFRTLAKNLDTVMFSTGILAVLRSLKLQGQYVGVMITASHNPYQDNGVKIVEPDGSMLLATWEPYAMQLANAASFATNFEEFRVELAKLIEHEKIDLNTTVVPHIVVGRDSRESSPYLLRCLTSSMASVFHAQVLDLGCVTTPQLHYITDLSNRRKLEGDTAPVATEQDYYSFFIGAFNELFATYQLEKRLSVPKLFIDTANGIGGPQLKKLLASEDWDVPAEQVEVINDRSDVPELLNFECGADYVKTNQRLPKGLSPSSFDSLYCSFDGDADRVVFYYVDSGSKFHLLDGDKISTLFAKFLSKQLELAHLEHSLKIGVVQTAYANGSSTAYIKNTLHCPVSCTKTGVKHLHHEAATQYDIGIYFEANGHGTIIFSEKFHRTIKSELSKSKLNGDTLALRTLKCFSELINQTVGDAISDMLAVLATLAILKMSPMDWDEEYTDLPNKLVKCIVPDRSIFQTTDQERKLLNPVGLQDKIDLVVAKYPMGRSFVRASGTEDAVRVYAECKDSSKLGQFCDEVVEHVKASA
Protein: 26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Mov34 protein homolog) (Proteasome subunit p40) (P51665)
Organism: Homo sapiens (Human)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Interaction partners:
- Proteasomal ubiquitin receptor ADRM1
- Proteasome subunit alpha type-1
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
- Proteasome subunit beta type-7
- 26S proteasome non-ATPase regulatory subunit 6
- Proteasome subunit beta type-4
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 3
- Proteasome subunit alpha type-2
Sequence:
MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDRKEDKEKDKDKEKSDVKKEEKKEKK
Protein: Large ribosomal subunit protein bL32m (Probable 54S ribosomal protein L32, mitochondrial) (O94379)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the large subunit of mitochondrial ribosome.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein bL36m
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein bL28m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS9m
Sequence:
MALLRGNSLAISQKMLSVFQASALPHISLRIFISPPSIANIWNSILLAVPKKKTSYTKKRSRLLSGKALKDKTVNRCPICGSFKLAHHLCSHCFRNIRREFNE
Protein: Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) (B1AZP2)
Organism: Mus musculus (Mouse)
Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane (By similarity).
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- SH3 and multiple ankyrin repeat domains protein 3
- Disks large homolog 4
- Disks large homolog 2
- Disks large homolog 3
- SH3 and multiple ankyrin repeat domains protein 1
- Ras/Rap GTPase-activating protein SynGAP
Sequence:
MKGLGDSRPRHLSDSLDPPHEPLFAGPDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPSHAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSMEGTAGKVGGNGSKKGGLEDGKGRRAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEGGAFRSGPASGLMTLGRQQERTQPRYFMHAYNTISGHMLKTTKNTTTELTAPPPPPAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRDMDSTAEGPIPCRRMRSGSYIKAMGDEDSDESGGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEDDYNPISDSLNDSSCISQVFGQASLIPQLFGHDQQVREADLSDQYEAACESACSEAESTTAEALDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTGSLSNSRTLPSSSCLVAYKKTPPPVPPRTTSKPFISVTVQSSTESAQDTYLDSQDHKSEVTSQSGLSNSSDSLDSSTRPPSVTRGGITPGPEAPEPPPKHAALKSEQGTLTSSESHSEAIPKRKLSSIGIQVDCIQPVPKEEPSPATKFQSIGIQVEDDWRSSAPSHSMSSRRDTDSDTQDANDSSCKSSERSLPDCTSHPNSISIDAGPRQAPKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPGACRRDGYWFLKLLQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGLCEQNLNPDANPRPTAQDLAGFWDLLQLSIEDISMKFDELYHLKANSWQLVETPEKRKEEKKPPPPVPKKPAKSKAAVSRDKASDAGDKQRQEARKRLLAAKRAASVRQNSATESADSIEIYVPEAQTRL
Protein: NAD-dependent protein deacylase Sirt4 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (Q8IRR5)
Organism: Drosophila melanogaster (Fruit fly)
Function: NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
Subcellular location: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03161}.
Interaction partners:
- Nicotinamide-nucleotide adenylyltransferase
- Glutamine-dependent NAD
- NAD
- purine-nucleoside phosphorylase
- NAD kinase 2, mitochondrial
- NAD-dependent protein deacetylase Sirt6
- Glutamate dehydrogenase, mitochondrial
- Histone deacetylase 11
- FI18188p1
- Glutamate dehydrogenase
Sequence:
MRVGQLLRFRSTSLRSSTARQEYVPHHKPVVEDDIKRLEDFLLSKPNVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHMEFVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGETRADHLADIKISAKCGDVIPKLFDFRNSKSVS
Protein: Putative inhibitor of glucose uptake transporter SgrT (C1P5Z7)
Organism: Escherichia coli (strain K12)
Function: Acts to promote recovery from glucose-phosphate stress due to intracellular accumulation of glucose-6-phosphate caused by disruption of glycolytic flux or in the presence of (toxic) non-metabolizable glucose phosphate analogs. It may do so by inhibiting the transporter activity for glucose uptake (PtsG) as cells that overexpress this protein do not seem to import glucose although they have nearly wild-type levels of PtsG.
Interaction partners:
- HTH-type transcriptional regulator SgrR
- PTS system glucose-specific EIICB component
- Pyridoxal phosphate phosphatase YigL
- Multidrug efflux pump accessory protein AcrZ
Sequence:
MRQFYQHYFTATAKLCWLRWLSVPQRLTMLEGLMQWDDRNSES
Protein: 24-methylenesterol C-methyltransferase 3 (24-sterol C-methyltransferase 3) (Sterol-C-methyltransferase 3) (EC 2.1.1.143) (Q94JS4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the methyl transfer from S-adenosyl-methionine to the methylene group of 24-methylene lophenol to form 24-ethylidene lophenol.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Methylsterol monooxygenase 2-2
- Methylsterol monooxygenase 2-1
- Probable 3-beta-hydroxysteroid-Delta
- 24-methylenesterol C-methyltransferase 2
- At2g33630/F4P9.40
- Delta
- Sterol 14-demethylase
- Putative Delta
- Ergosterol biosynthetic protein 28
- Delta
Sequence:
MDSVALYCTAGLIAGAVYWFICVLGPAERKGKRASDLSGGSISAEKVKDNYNQYWSFFRKPKEIESAEKVPDFVDTFYNLVTDIYEWGWGQSFHFSPHVPGKSDKDATRIHEEMAVDLIKVKPGQKILDAGCGVGGPMRAIAAHSKAQVTGITINEYQVQRAKLHNKKAGLDSLCNVVCGNFLKMPFDENTFDGAYSIEATCHAPKLEEVYSEIFRVMKPGSLFVSYEWVTTEKYRDDDEEHKDVIQGIERGDALPGLRSYADIAVTAKKVGFEVVKEKDLAKPPSKPWWNRLKMGRIAYWRNHVVVVILSAIGVAPKGTVDVHKMLFKTADYLTRGGETGIFSPMHMILCRKPEKASE
Protein: Zinc finger protein 791 (Q3KP31)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein 766
Sequence:
MDSVAFEDVSVSFSQEEWALLAPSQKKLYRDVMQETFKNLASIGEKWEDPNVEDQHKNQGRNLRSHTGERLCEGKEGSQCAENFSPNLSVTKKTAGVKPYECTICGKAFMRLSSLTRHMRSHTGYELFEKPYKCKECEKAFSYLKSFQRHERSHTGEKPYKCKQCGKTFIYHQPFQRHERTHIGEKPYECKQCGKALSCSSSLRVHERIHTGEKPYECKQCGKAFSCSSSIRVHERTHTGEKPYACKECGKAFISHTSVLTHMITHNGDRPYKCKECGKAFIFPSFLRVHERIHTGEKPYKCKQCGKAFRCSTSIQIHERIHTGEKPYKCKECGKSFSARPAFRVHVRVHTGEKPYKCKECGKAFSRISYFRIHERTHTGEKPYECKKCGKTFNYPLDLKIHKRNHTGEKPYECKECAKTFISLENFRRHMITHTGDGPYKCRDCGKVFIFPSALRTHERTHTGEKPYECKQCGKAFSCSSYIRIHKRTHTGEKPYECKECGKAFIYPTSFQGHMRMHTGEKPYKCKECGKAFSLHSSFQRHTRIHNYEKPLECKQCGKAFSVSTSLKKHMRMHNR
Protein: tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) (M.SpomI) (SpIM.SpoI) (P40999)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Can also methylate cytosine 38 in tRNA(Glu), albeit to a lower level, but not tRNA(Lys). Pmt1-dependent tRNA methylation is induced by nitrogen limitation and depends on the nutrient-sensing protein kinase sck2. Does not have DNA-methylation activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Queuine tRNA-ribosyltransferase catalytic subunit
- Multisite-specific tRNA:
- Multisite-specific tRNA:
- Protein Dicer
- 25S rRNA
- Ammonium transporter 2
- DNA repair protein rad8
- tRNA
- Serine/threonine-protein kinase sck2
Sequence:
MLSTKRLRVLELYSGIGGMHYALNLANIPADIVCAIDINPQANEIYNLNHGKLAKHMDISTLTAKDFDAFDCKLWTMSPSCQPFTRIGNRKDILDPRSQAFLNILNVLPHVNNLPEYILIENVQGFEESKAAEECRKVLRNCGYNLIEGILSPNQFNIPNSRSRWYGLARLNFKGEWSIDDVFQFSEVAQKEGEVKRIRDYLEIERDWSSYMVLESVLNKWGHQFDIVKPDSSSCCCFTRGYTHLVQGAGSILQMSDHENTHEQFERNRMALQLRYFTAREVARLMGFPESLEWSKSNVTEKCMYRLLGNSINVKVVSYLISLLLEPLNF
Protein: Uncharacterized protein (Q59QN2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Serine/threonine-protein phosphatase SIT4
Sequence:
MSFWPFTNSMNSNNALSKFLDSAQDLSSITAEDLIGDPTLSEELLNELHNIKGNYNSRNGVASFSFSQPQTINEATVSNSDSASFTSSSNDINTGNTKDSRGRKLLEILIQPHILSGLIEYVEKSVDFFYEQSIKENEKVLDLLNENPPETDIQEEEELKKIRQKNGIKSDDDDDDDIEDDENEEEESEDSKFRRCVQAAADILSIDLWIISNRIIETESLINKLWRIIDLNNLSESSPSVSYLVHILDQLMDANSIELLNFFRRQKNLVDTFLSKIEVPILMDFFFRLIQTDKQDSPTGIIDTIASQNIISKLIEILKPETSQFASQNCIPNHQLFFKQTAATDFLKALVNISSNAALASVVETNIGPNQLTRELVSPTVINTMINDIMLVKISDENGKTQTNKHGINNVVSIIIELIRKNNSDYDLNCGTYSSMLQNGDGGPIEVNSYVMYQWLKDFEQNPPGPRDPIYLGEMLDLFSSNLDRIAALIQTEPIPPPHVTSNILGFTRFKLSELIAELLHCSNMILLNSRKIKKIIQVRDQIRSQQEKRLQKALQEQISFSDSPNINQVTTGLDDVSLDDIHFASHSNDEVHDYGKLLDNLDQEEDSEDDEPSISPENPFVCSERDKSMRQDPCVGDYFKIKLLDSGILYDIISMFTKFPWNNFFHNVVFDLIQQIFNGKLNSYNSFLIVELFKEDQCNLTDIVVSSYKEDTNPRPGYMGHLILISEEIVKFTSLYKPDLISPVIVSAVQSEKWTWFINDVLLKTREIYNVVLGAEDSDGNNDYGFDTSSVGYLDMDQPKKIILGDASNHDEFINDNSGNQNNGGVSESEQEQTSNDLNDLGDDYDMNQFFVPDINVSKMSPSGDLTKHNIEDDCDDDLDEHHDDSSDKYLENLSDSSSEDEDEDEDIGETNKLKRVPTHNDD
Protein: Superoxide dismutase [Fe] (EC 1.15.1.1) (P17550)
Organism: Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Interaction partners:
Sequence:
MLYEMKPLGCEPAKLTGLSEKLIFSHYENNYGGAVKRLNAITATLAELDMATAPVFTLNGLKREELIATNSMILHEVYFDSLGDGGSLDGALKTAIERDFGSVERWQAEFTAMGKALGGGSGWVLLTYSPRDGRLVNQWASDHAHTLAGGTPVLALDMYEHSYHMDYGAKAAAYVDAFMQNIHWQRAATRFAAAVRD
Protein: WRKY transcription factor 18 (WRKY DNA-binding protein 18) (AtWRKY18) (Q9C5T4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Positively modulates defense-related gene expression and disease resistance.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable WRKY transcription factor 40
- Probable WRKY transcription factor 60
- High mobility group B protein 6
- Magnesium-chelatase subunit ChlH, chloroplastic
- Regulatory protein NPR1
- F22C12.10
- Lipase-like PAD4
- Protein ABSCISIC ACID-INSENSITIVE 5
- Ethylene-responsive transcription factor ABI4
- Transcription factor MYC2
Sequence:
MDGSSFLDISLDLNTNPFSAKLPKKEVSVLASTHLKRKWLEQDESASELREELNRVNSENKKLTEMLARVCESYNELHNHLEKLQSRQSPEIEQTDIPIKKRKQDPDEFLGFPIGLSSGKTENSSSNEDHHHHHQQHEQKNQLLSCKRPVTDSFNKAKVSTVYVPTETSDTSLTVKDGFQWRKYGQKVTRDNPSPRAYFRCSFAPSCPVKKKVQRSAEDPSLLVATYEGTHNHLGPNASEGDATSQGGSSTVTLDLVNGCHRLALEKNERDNTMQEVLIQQMASSLTKDSKFTAALAAAISGRLMEQSRT