wanglab/gogpt-training-data huggingface dataset:
Protein: Regulator of G-protein signaling 12 (RGS12) (O08774)
Organism: Rattus norvegicus (Rat)
Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.
Subcellular location: Nucleus {ECO:0000269|PubMed:16819986}. Cytoplasm {ECO:0000269|PubMed:16819986}. Cell projection, dendrite {ECO:0000269|PubMed:16819986}. Synapse {ECO:0000269|PubMed:16819986}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- C-X-C chemokine receptor type 2
- Regulator of G-protein signaling 3
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein G
Sequence:
MYRAGEPGKRQSGPAPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAINEINVKKASHEDVVKLIGKCSGVLRMVISEGSSHVEPSSSDEEGGLCEGKGWLRPKLDSKALGINRAERVVEEVQSGGIFNMIFESPSLCASGSEPLKLKQRSLSESAALRLDVGQDSLCTPHPSMLSKEEISKVINDDSVFTVGLDNHDDFGLDASILNVAMVVGYLGSIELPSTSSNLEHDSLQAIRGCMRRLRAEQKIHSLVTMKVMHDCVQLVTDRAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGCLAQEDEGALRTSCHVFMVDPDLFHHKIHQGIARRFGFACTADPDTSGCLEFPASSLPVLQFISVLYRDMGELIEGVRARAFLDGDADAHQNNSTSSNSDSGIGNFNQEEKSNRVLVVDLGGGSSRHGQGSSPGWESVSGRGSQPWSAPWNGTFCHDSEAGSPLETSPNTDRFWDLTKHSGPVFHMEVPPATLRSSIPPSKRGATGSSCGFNQRWLPVHVLQEWQCGHASDQESYTDSTDGWSSVNCGTLPPPMSKIPADRYRVEGSFAQAPLSTQKRDWSRKAFGMQNLFGPHRNVRKTKEDKKSSKLGRGVALAQTSQRTSARRSFGRSRRFSLTRSLDDLESATVSDGELTGADLKDCISNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVLAEVEGRTLPDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEKKRKGAFFSWSRSRSTGRSQKKKDHGDHAHDALHANGGLCRRESQGSVSSAGSLDLSEACRTSALERDKAAKHCCVHLPDGTSCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGGDKPLVLHQDSSILATRDLRLGKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRLSGEKEPLDLGAPISSLDGQRVILEERDPSRGKVSTEKQKGAPVKQSSAVNSSPRNHSAMGEERTLGKSNSIKIRGENGKSARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADDQRGLLRKEDLVLPEFLRLPPGSSELALSSPPPVKGFSKRAVTSHGQEGAVQTEESYSDSPATSPASAQSPCSAYSPGSAHSPGSAHSPGSAHSTPGPPGTAQPGEKPTKPSCISTVQEGTTQAWRRLSPELEAGGIQTVEEEQVADLTLMGEGDISSPNSTLLPPPPLPQDTPGPTRPGTSRF
Protein: Skb1 localization factor 1 (Q9UT50)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cell membrane {ECO:0000269|PubMed:25009287}.
Interaction partners:
- Protein arginine N-methyltransferase skb1
Sequence:
MSSIIQNPIESSYFVEDLSAVGNSQLHSGRSLTYGDRKANIDTRSGGGRRFWSNLNDSGNSFGAVPASSMNLSYGPTKSATISSKDGAMSRSSRYYVSSELKATLPSLDGRRLSKRNAANHASHHRMPDESASYRTRGEYESSSPRVPQKSLRRYYSTRTAQRLDVRRPASRSSRYSKTSDLPPSDPGRFVDDSDLTPHTDFTNRFVDSDFDPDSGVGRSSSPDQMMSRNNNLNINARMTSTSSKPYAKENQQLISSMAPVEQKNSFSTAREQYVAPALSFAEPVETQHNHMPKTTPLRGTSTVMNGSPIGPYSSSSNATGMYGVSKGHSSSTRRPFFSDVGSSQPAEEFVGSSSSHGRQQDSYIADDSDSERSYRRVRDQYLSKPRLSDKNRYSTFSEFPGQGTPSASQSNLRRSNTVRPTSFYYEKLHIKNDNPSFQALPYETTTQERKPVVKPDSIKTVKPEKKKSKGFFKKLMHKISHIFD
Protein: Insulin-like growth factor 2 (Insulin-like growth factor II) (IGF-II) (Multiplication-stimulating activity) (MSA) (Multiplication-stimulating polypeptide) [Cleaved into: Preptin] (P01346)
Organism: Rattus norvegicus (Rat)
Function: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01344, ECO:0000250|UniProtKB:P09535}.
Interaction partners:
- Insulin-like growth factor-binding protein 1
- Insulin-like growth factor 1 receptor
- Cation-independent mannose-6-phosphate receptor
- Insulin-like growth factor-binding protein 3
- Insulin-like growth factor-binding protein 2
- Insulin-like growth factor-binding protein 6
- Insulin-like growth factor-binding protein 5
- Glypican-3
- Insulin-like growth factor 1
- Insulin receptor
Sequence:
MGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLPDDFPRYPVGKFFKFDTWRQSAGRLRRGLPALLRARRGRMLAKELEAFREAKRHRPLIVLPPKDPAHGGASSEMSSNHQ
Protein: Probable ATP-dependent RNA helicase Dbp45A (DEAD box protein 45A) (EC 3.6.4.13) (Q07886)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable ATP-binding RNA helicase.
Interaction partners:
- LD41718p
- Bystin
- Nucleolar protein 6
- Something about silencing protein 10
- Uncharacterized protein, isoform A
- Probable ATP-dependent RNA helicase DDX52
- rRNA biogenesis protein RRP5
- Ribosomal RNA small subunit methyltransferase NEP1
- Probable ATP-dependent RNA helicase kurz
- LD31322p
Sequence:
MQRKEANPFQILGLRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPILERLSEEPVSHFALVLTPTHELAYQISEQFLVAGQAMGVRVCVVSGGTDQMVESQKLMQRPHIVVAMPGRLADHLTGCDTFSFDNLKYLVVDEADRMLNGDFDESLSIIERCLPKTRQNLFFSATMKDFIKESSIFPIASDCFEWSQDSDVATVETLDQRYLLCADYDRDMVLIEALRKYREENENANVMIFTNTKKYCQLLSMTLKNMEIDNVCLHGFMRQKERVAALSRFKSNQIRTLIATDVAARGLDIPSVELVMNHMLPRTPKEYIHRVGRTARAGRKGMSISIFRFPRDLELLAAIEEEINTKLTEHPIDQRMVERIFMQVNVTRRESEMQLDNNDFDERAQNYRRKTWIMEGKDPDQMEALYRKKQKDKLREIRRKRKLQHAEPAASEEGKALLQDERFKSVDSARFEKKGKGRSRATQEDTPTKPLKRLNKEKPVAQKGRADVKKDKA
Protein: Cyclin-dependent kinase 5 activator (Q8TAM4)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}. Cell projection, neuron projection {ECO:0000256|ARBA:ARBA00004487}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Perikaryon {ECO:0000256|ARBA:ARBA00004484}.
Interaction partners:
Sequence:
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSKVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
Protein: Pyrroline-5-carboxylate reductase (EC 1.5.1.2) (A0A0S2Z5U6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTLTPSSPGKLLTRSLALGGKKD
Protein: Orf288 protein (Q8HCQ2)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MHDDPIIILLILLILVFVSRMLVRALWPRSAVLTSRIFTTFVVLSSAVLSGSVAHAADNEPINNGAAPAAYGSGAEGPSNSALFTYTSDLAEDSVSSGRSRSTASSSFQESTGEMDALMASTTPSAPRTPSGGEPSVNQPLPGEQAMPPALPVMQEAANRALPYAPYPYPVDEIIGGDCVQSIQRRILGANLNPSAHDMQMSRIQAEDLFELKVQIIRKMATLHPSGDWMGWGARALDNPRTATGEEDLAKLHKMLDDLQSRNEQSATFWRLVERVRLRADEDQNSAS
Protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.24) (B7WPL9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514, ECO:0000256|RuleBase:RU365032}.
Interaction partners:
Sequence:
MWSLTASEGESTTAHFFLGAGDEGLGTRGIGMRPEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPARPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVKHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGGEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDPQRETLAPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDGDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTRSTSLLNSMTIIQNPVKVCDQVFALIENLTHQIRERMQDPRSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKLEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALDYLSAISELNYMTQIVIMLYEDNTQDPLSEERFHVELHFSPGVKGVEEEGSAPAGCGFRPASSENEEMKTNQGSMENLCPGKASDEPDRALQTSPQPPEGPGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARSHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLSRVCQRHTDAQAQASAALFDSMHSSQASDNPFSPPRTLHSPPLQLQQRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSQFGFSDQPSLNSHVAEEHQGLGLLQETPGSGAQELSIEGEQELFEPNQSPQVPPMETSQPYEEVSQPCQEVPDISQPCQDISEALSQPCQKVPDISQQCQENHDNGNHTCQEVPHISQPCQKSSQLCQKVSEEVCQLCLENSEEVSQPCQGVSVEVGKLVHKFHVGVGSLVQETLVEVGSPAEEIPEEVIQPYQEFSVEVGRLAQETSAINLLSQGIPEIDKPSQEFPEEIDLQAQEVPEEIN
Protein: Candida glabrata strain CBS138 chromosome K complete sequence (Q6FND0)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Phosphoribosylglycinamide formyltransferase
- Candida glabrata strain CBS138 chromosome A complete sequence
- Methylenetetrahydrofolate dehydrogenase [NAD
- Serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- 5-formyltetrahydrofolate cyclo-ligase
- Methionyl-tRNA formyltransferase, mitochondrial
- thymidylate synthase
- Dihydrofolate reductase
- Candida glabrata strain CBS138 chromosome F complete sequence
Sequence:
MAELIDGKACAQGIRASIKEEIEAIKQQNPSFVPTLTIVQVGDRPDSATYVRMKRKAAEEAGIRADFLHLAEDVSENELYEEVTKLNENPDIHGVIVQLPLPGHINEDKITSAVVAEKDVDGFGPINIGELNKKNGKPFFLPCTPKGIIELLKQAGVQIAGSKSVVIGRSDIVGSPVAELLKSLDSTVTITHSKTPDIPSYLNDADIVVVAIGKPEFVKGEWFANNKKGAVVIDVGTNYVDDSTKKSGYRCCGDVEFKEACKYVRKITPVPGGVGPMTVAMLMQNTLIAAKRQLETGGKLSEFEPLPLQLKRPVPSDFEISRAQKPKQITKVALEAGILPSELEPYGSTKAKVSLNILDRLKDRENGKYILVTGITPTPLGEGKSTTTVGLTQALGAHLNKTVFANVRQPSMGPTFGIKGGAAGGGYSQVIPMDEFNLHVTGDIHAISMANNLLAAAIDTRMFHESTQKDGPLYKRLVPAKKGERKFTPTMLRRLKKLGIDKTNPDDLTDEEITRFARLDIDPETITWRRVVDCNDRFLRGITVGEAPTEKGFTRKTGFDISVASECMAILALCNSLSDMRERLGKIVVAASKSGEPITCEDIGCAGAMTALLKDAVKPNIMQTLEGTPVFVHAGPFANISIGANSVLADKIALKLAGVDPKLPEEKKKEQVGYVVTEAGFDFTMGGERFLNIKCRSSGLVPDVVVIVATVRALKVHGGGPEVKAGAPLPSEYLNEDVELLRKGCANLAKHIENAKQYNLPVVVAINKMSSDTDKEHEVIREESLKAGAYDAIVSDHWAEGGAGAVDLAKGIIKAADETDNSKFSFLYESQGKVEDKIQKIANAMYGAKDVEFLPEAQKKIDLYTKQGFGDLPICIAKTQYSLSHDANLKGVPKDFTFPIRDIRASIGAGYLYALAAEIQTIPGLPTHCGFMNIEVNEDGEIEGMF
Protein: DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) (Q57XW9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- S-adenosylmethionine synthase
- S-adenosylmethionine synthase
- S-adenosylmethionine synthase
- Adenosylhomocysteinase
- S-adenosylmethionine decarboxylase proenzyme
- S-adenosylmethionine decarboxylase proenzyme-like, putative
- 2,4-dienoyl-coa reductase-like protein
- DUF4139 domain-containing protein
Sequence:
MCSVAPLASHGTGCPVAACIVRCKRHLSAVVCRLRKLKRLRSGRNVTTFNANFYEAVAEERRYGAFTDGEHFDDCTLHLRRWMLRRVTCAPTFATSVTGSVETNEVLTMWTKLSDGGVVWNILQKEQQCYAVHFIGELSSDFVKELFNCTVDEYRSGSHNGVVLCIVQQLRVYSEACCRPEDFPPPLYELRAAALRTQVLHQCGSAGAFPTSTKLGKRSENGSDCFTFSELFAGMGMFRVGLERIGGKCVFAVECAPHARSVYHANHHLPRRNSCGNEALPATRRPVPLVGDITTVPSHYFPHHDVLTAGFPCQSFAKAGSATGLRDTKGQLFYEVVRVIQSAKPKGFLLENVENVLHVGGEDGGEANASEESQHHLKFILDALRSPSPDSNEALTYVVAYRVIDGALVTPQRRRRAYFVGIRADLPRANARDVGAVLDDAVRQLRAYRDMHPEAPRCVRDILDSTGDTSEMGEFNQSLVSLRLTESQWAAVQRSVTFRRSPSWRVSDLNGLARTLMGSYRASYQLYSEFVPLPDGGPPFRFYSIRECARLQGIPDWFSFNVVCYPLSLEKCNGRSGPSHGSDKGCERCVPVGAVYKLIGNAVNPIVVECLGRALLSRILK
Protein: 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) (A0A0D9SFP2)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
MCRTALGVTTLQDLGVCWRKEHDPAEMLRVGRAELGGWKPSWEAIVKEVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK
Protein: Structural maintenance of chromosomes protein (Q7KK96)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
Interaction partners:
- Condensin complex subunit 1
- Structural maintenance of chromosomes protein
- Condensin complex subunit 2
- Chromosome associated protein G, isoform F
- Chromosome associated protein H2, isoform E
- Condensin-2 complex subunit
- DNA topoisomerase 2
- Kinesin-like protein Klp61F
- Kinetochore protein NDC80
- Enhanced level of genomic instability 1
Sequence:
MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRVTLIPINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVSTITRQVSRQATTNKR
Protein: Toxin BmKAEP (Anti-epilepsy peptide) (BmK AEP) (P15228)
Organism: Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Function: Shows anti-epileptic activity. Shares high homology with depressant insect toxins, but shows very weak toxicity against mammals and insects and no obvious symptoms on insect larvae. May target voltage-gated sodium channel (Nav).
Subcellular location: Secreted.
Interaction partners:
Sequence:
MKLFLLLVISASMLIDGLVNADGYIRGSNGCKVSCLLGNEGCNKECRAYGASYGYCWTWKLACWCQGLPDDKTWKSESNTCGGKK
Protein: Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD(+)-specific ICDH) (P28834)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.
Subcellular location: Mitochondrion.
Interaction partners:
- Aconitate hydratase, mitochondrial
- Isocitrate dehydrogenase subunit 2, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
- Isocitrate dehydrogenase
- Citrate synthase, mitochondrial
- Glutamate synthase
Sequence:
MLNRTIAKRTLATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM
Protein: Killer cell immunoglobulin-like receptor 3DL2 (CD158 antigen-like family member K) (Natural killer-associated transcript 4) (NKAT-4) (p70 natural killer cell receptor clone CL-5) (p70 NK receptor CL-5) (CD antigen CD158k) (P43630)
Organism: Homo sapiens (Human)
Function: Receptor on natural killer (NK) cells and T cells for MHC class I molecules. Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions. Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- HLA class I histocompatibility antigen, B alpha chain
- HLA class I histocompatibility antigen, A alpha chain
- HLA class I histocompatibility antigen, alpha chain F
- Killer cell immunoglobulin-like receptor 2DL1
- Killer cell immunoglobulin-like receptor 3DL1
- Killer cell immunoglobulin-like receptor 2DL3
- Killer cell immunoglobulin-like receptor 3DL3
- Natural killer cells antigen CD94
- NKG2-A/NKG2-B type II integral membrane protein
- HLA class I histocompatibility antigen, alpha chain G
Sequence:
MSLTVVSMACVGFFLLQGAWPLMGGQDKPFLSARPSTVVPRGGHVALQCHYRRGFNNFMLYKEDRSHVPIFHGRIFQESFIMGPVTPAHAGTYRCRGSRPHSLTGWSAPSNPLVIMVTGNHRKPSLLAHPGPLLKSGETVILQCWSDVMFEHFFLHREGISEDPSRLVGQIHDGVSKANFSIGPLMPVLAGTYRCYGSVPHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVQAGENVTLSCSSWSSYDIYHLSREGEAHERRLRAVPKVNRTFQADFPLGPATHGGTYRCFGSFRALPCVWSNSSDPLLVSVTGNPSSSWPSPTEPSSKSGICRHLHVLIGTSVVIFLFILLLFFLLYRWCSNKKNAAVMDQEPAGDRTVNRQDSDEQDPQEVTYAQLDHCVFIQRKISRPSQRPKTPLTDTSVYTELPNAEPRSKVVSCPRAPQSGLEGVF
Protein: Collagen triple helix repeat protein (H2L2C4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKANAGPVPPRNRTTRQAYGGPEVNPAPNLQCEGCCLPGPPGPAGAPGKPGKPGRPGAPGTPGTPGKPPVAPCEPTTPPPCKPCPQGPPGPPGPPGAPGDPGEAGTPGRPGTDAAPGSPGPRGPPGPAGEAGAPGPAGEPGTPAISEPLTPGAPGEPGDSGPPGPPGPPGAPGNDGPPGPPGPKGAPGPDGPPGVDGQSGPPGPPGPAGTPGEKGICPKYCALDGGVFFEDGTRR
Protein: Protein FERTILITY RESTORER RF2, mitochondrial (F1SZ44)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Non-functional allele of the RF2 fertility restorer of rice varieties with LD-type cytoplasmic male sterility (CMS). Non-functional RF2 alleles are found in japonica cultivars Taichung 65 and Nipponbare (AC F1SZ44), and is due to the presence of Thr-78 which replaces Ile-78 in the functional allele. Functional allele is found in the japonica cultivars Fukuyama and Owarihatamochi (AC F1SZ42), and indica cultivar Kasalath (AC F1SZ41).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21265890}.
Interaction partners:
Sequence:
MSTLVTCSLPGAVTTHASTRRFGGSQFQTSQASCISFKREVSAKAVLRSVRCNATQTQSAQRKSSTATVKRSDPKGKTQGPKLDDGSGGFPPFRFGKGGGGGGGGGGGSNYFGGFLLFTCVLLLDYLKEFEKNLIARRQRAGYDANNDMFQQ
Protein: Protein pelota homolog (Q80X73)
Organism: Mus musculus (Mouse)
Function: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BRX2}.
Interaction partners:
- HBS1-like protein
- Ubiquitin-like protein FUBI
- ATP-binding cassette sub-family E member 1
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein uS3
- GTP-binding protein 2
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein eS12
Sequence:
MKLVRKDIEKDNAGQVTLVPEEPEDMWHTFNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHVCLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHINFEVVKCVLVASPGFVREQFCDYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVERANEALAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLGQLTGVAAILRFPVPELSDQEDDSSSEED
Protein: Fibronectin type III and SPRY domain-containing protein 1 (MID1-related protein 1) (Microtubule-associated protein GLFND) (Q9BTV5)
Organism: Homo sapiens (Human)
Function: May be involved in microtubule organization and stabilization.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Cleavage furrow. Note=Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associate with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle.
Interaction partners:
Sequence:
MEEQREALRKIIKTLAVKNEEIQSFIYSLKQMLLNVEANSAKVQEDLEAEFQSLFSLLEELKEGMLMKIKQDRASRTYELQNQLAACTRALESSEELLETANQTLQAMDSEDFPQAAKQIKDGVTMAPAFRLSLKAKVSDNMSHLMVDFAQERQMLQALKFLPVPSAPVIDLAESLVADNCVTLVWRMPDEDSKIDHYVLEYRRTNFEGPPRLKEDQPWMVIEGIRQTEYTLTGLKFDMKYMNFRVKACNKAVAGEFSEPVTLETPAFMFRLDASTSHQNLRVDDLSVEWDAMGGKVQDIKAREKDGKGRTASPINSPARGTPSPKRMPSGRGGRDRFTAESYTVLGDTLIDGGEHYWEVRYEPDSKAFGVGVAYRSLGRFEQLGKTAASWCLHVNNWLQVSFTAKHANKVKVLDAPVPDCLGVHCDFHQGLLSFYNARTKQVLHTFKTRFTQPLLPAFTVWCGSFQVTTGLQVPSAVRCLQKRGSATSSSNTSLT
Protein: Pro-glucagon [Cleaved into: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] (P68259)
Organism: Gallus gallus (Chicken)
Function: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
Subcellular location: Secreted.
Interaction partners:
- Appetite-regulating hormone
- Glucagon-like peptide 1 receptor
- Peptide YY-like
- Glucagon receptor-like protein
- Uncharacterized protein
- Dipeptidyl peptidase 4
- Insulin
- Glucagon-like peptide 2 receptor
- Cholecystokinin
- G protein-coupled receptor 119
Sequence:
MKMKSIYFIAGLLLMIVQGSWQNPLQDTEEKSRSFKASQSEPLDESRQLNEVKRHSQGTFTSDYSKYLDSRRAQDFVQWLMSTKRNGQQGQEDKENDKFPDQLSSNAISKRHSEFERHAEGTYTSDITSYLEGQAAKEFIAWLVNGRGRRDFPEKALMAEEMGRRHADGTFTSDINKILDDMAAKEFLKWLINTKVTQRDLLGEYQ
Protein: Glial cell line-derived neurotrophic family receptor-like, isoform H (Q59DV8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Interaction partners:
Sequence:
MLKPFAVIIGIFYLGSTIKGVVAILNCILARQLCFEDPSCSAILEIIPRVCGPIPVSCSTVTVTKCQAALRTLQAFQFFRPTCLCKEPGMDPDCNHFRDFLFDHPCGFVLKKAEKDPYPIDALPTCNHALSVCQQERKCLKLFEDFKTHCKVRDNKCKMENRDACHDSWTNLRLSPMFGCICPNNHMKKRCDRIFNIVNHNPCVDRLIFFPNGLPKLKQPRPKAKPRPKPKPKSKPKPRQRHHGMNGTELMTNNIEYHDEPNGLSDPEDEANETVDEDPGGHGDEDEDEEDDDYDDRIRAEIYSNYPHYLHPPSWGINNPLVLASHSPHTLDDDDDVVVEVVANKKPPPVTLHHHNDELDHDVVVVVDAGPHSHSHPHSHTFYSHGDQSSTTGSGLPGPAPTIPSPPNTGTKMHKTAPLGDLVAGSDITHRTYTGPSMDERGGQDVEVDLSTEIIKQHFQSTCHTALDTCREDPSCSSSLQPMLTHCELHRCNRNACMSSLQAFYKGPHEDLNLDIAFCLCKKTSSQQNGNGNRHDMCMIAQEKLHPVCAQRPPDNSNPASSNGIYYHPPPACHVVADSCKEDRECRLKLEYYEQACAVDSVTKKCAGRPSGCRTAMIGILGTMLRTTCACQGTDPQHLYQCVGWRRLLWMNPCVVEAQKDFHMKRLAELGFLTTTTTTTTTTTTTTTTTTTRAPPPPPPPTTTTTTTTSMQPRQTPRKPATHIFKDVITAKEKSEPTSVEHNYLDPPDSIPLPSVNVESGGNGGNDDYHNGNGNGHGNGNGNGRRKNGGKGRGGSVDFDDPVIFVDPRETTEFVGISITEPVTTTTTTMATTTTTQPPRNCVVQRPRQSDQLIREGSSKRIYSLDDVECSELCSCGESLILTCHALCVPFAPCRTALAFYSHASPAYQAFRGRCLCYSGRFICMKPPLGEYILPGGIFLLLGYSAADEALLRPHTNLGVQDAVRALQQYVTTYIDNQTQCTLTLFNMTEENIIIAARLPHDGKLKDIELLRKEKDECTAILKTISHQINSEHSELQSHRLLSIFKMSEVEVVWPESTSAAARSGHGPGQFAGCDRLLYAAMLALAYLSSWTTLRMSDVAT