wanglab/gogpt-training-data huggingface dataset:
Protein: F-box only protein 43 (Endogenous meiotic inhibitor 2) (Q8CDI2)
Organism: Mus musculus (Mouse)
Function: Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis.
Interaction partners:
- Serine/threonine-protein kinase PLK1
- Cell division cycle protein 20 homolog
- Cyclin-dependent kinase 1
- S-phase kinase-associated protein 1
- G2/mitotic-specific cyclin-B1
- Cullin-1
- Calcium/calmodulin-dependent protein kinase type II subunit gamma
- F-box/WD repeat-containing protein 1A
- E3 ubiquitin-protein ligase RBX1
- F-box/WD repeat-containing protein 11
Sequence:
MDSSAVTVKGLSLIDFCSTSSFKYRGHHELSESCSLNKKEEEPMLTCEHPETPSLGSPNSAVSPSQIMKSVSLRKEKDKSPELCETPKLRRKKCTLRRRLDFSFPLLKGDSDSQSRSLESNISQGVSLEKHLPGSTSGFPKEDNFSPLVTSTIKTEDVVSNSQNSRLHFSQHKTSTIEDSKDNCGLFEVECLSPIEGNDFKDSITHFSDSSLSVSDENTCPELLGSCGSQTTYGADVTTSVTPVSSLIAKIKFNGNQTLDSSGEVRDSLFTPEDSGFCSLSWDKSEDFLSDQEGSFQELLQKHRVTPKVGDQVKKPKHFGRLRRLSTLQEQGQSEDEMQTVHPNSDSGVLESLQGSEEKRGNLALSFKDLSNTPALQLVQELFMKSKRKRSQQEDDQEFFEDRDEGKIARLQRVLAGLIGKKMGIEQLDILTELQYRNLKHILAMVLESLTSESLYSAWNVSRNWREIVAQDKKANRRRKLYIIQLRASAQGAAVLRVQDAATRLCLLSRLALRSVQAQAQAPSGEQVPTLSPWGDVLTPVASSSLTHLRSKQEQYVKVARTLFTDEALKPCPRCQSPAKYQPHKKRGLCSRLACGFDFCVLCLCAYHGSEDCRRGSAKARGSKDVLPGSAQSKRNLKRL
Protein: Peptidase M12B domain-containing protein (H2L2A7)
Organism: Caenorhabditis elegans
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRSIGGSFHLLQPVVAALILLVVCLVYALQSGSGTISEFSSDVLFSRAKYSGVPVHHSRWRQDAGIHVIDSHHIVRRDSYGRRGKRDVTSTDRRRRLQGVARDCGHACHLRLRSDDAVYIVHLHRWNQIPDSHNKSVPHFSNSNFAPMVLYLDSEEEVRGGMSRTDPDCIYRAHVKGVHQHSIVNLCDSEDGLYGMLALPSGIHTVEPIISGNGTEHDGASRHRQHLVRKFDPMHFKSFDHLNSTSVNETETTVATWQDQWEDVIERKARSRRAANSWDHYVEVLVVADTKMYEYHGRSLEDYVLTLFSTVASIYRHQSLRASINVVVVKLIVLKTENAGPRITQNAQQTLQDFCRWQQYYNDPDDSSVQHHDVAILLTRKDICRSQGKCDTLGLAELGTMCDMQKSCAIIEDNGLSAAFTIAHELGHVFSIPHDDERKCSTYMPVNKNNFHIMAPTLEYNTHPWSWSPCSAGMLERFLENNRGQTQCLFDQPVERRYYEDVFVRDEPGKKYDAHQQCKFVFGPASELCPYMPTCRRLWCATFYGSQMGCRTQHMPWADGTPCDESRSMFCHHGACVRLAPESLTKIDGQWGDWRSWGECSRTCGGGVQKGLRDCDSPKSENEVETLKSNVTSRPRNGGKYCVGQRERYRSCNTQECPWDTQPYREVQCSEFNNKDIGIQGVASTNTHWVPKYANVAPNERCKLYCRLSGSAAFYLLRDKVVDGTPCDRNGDDICVAGACMPAGCDHQLHSTLRRDKCGVCGGDDSSCKVVKGTFNEQGTFGYNEVMKIPAGSANIDIRQKGYNNMKEDDNYLSLRAANGEFLLNGHFQVSLARQQIAFQDTVLEYSGSDAIIERINGTGPIRSDIYVHVLSVGSHPPDISYEYMTAAVPNAVIRPISSALYLWRVTDTWTECDRACRGQQSQKLMCLDMSTHRQSHDRNCQNVLKPKQATRMCNIDCSTRWITEDVSSCSAKCGSGQKRQRVSCVKMEGDRQTPASEHLCDRNSKPSDIASCYIDCSGRKWNYGEWTSCSETCGSNGKMHRKSYCVDDSNRRVDESLCGREQKEATERECNRIPCPRWVYGHWSECSRSCDGGVKMRHAQCLDAADRETHTSRCGPAQTQEHCNEHACTWWQFGVWSDCSAKCGDGVQYRDANCTDRHRSVLPEHRCLKMEKIITKPCHRESCPKYKLGEWSQCSVSCEDGWSSRRVSCVSGNGTEVDMSLCGTASDRPASHQTCNLGTCPFWRNTDWSACSVSCGIGHRERTTECIYREQSVDASFCGDTKMPETSQTCHLLPCTSWKPSHWSPCSVTCGSGIQTRSVSCTRGSEGTIVDEYFCDRNTRPRLKKTCEKDTCDGPRVLQKLQADVPPIRWATGPWTACSATCGNGTQRRLLKCRDHVRDLPDEYCNHLDKEVSTRNCRLRDCSYWKMAEWEECPATCGTHVQQSRNVTCVSAEDGGRTILKDVDCDVQKRPTSARNCRLEPCPKGEEHIGSWIIGDWSKCSASCGGGWRRRSVSCTSSSCDETRKPKMFDKCNEELCPPLTNNSWQISPWTHCSVSCGGGVQRRKIWCEDVLSGRKQDDIECSEIKPREQRDCEMPPCRSHYHNKTSSASMTSLSSSNSNTTSSASASSLPILPPVVSWQTSAWSACSAKCGRGTKRRVVECVNPSLNVTVASTECDQTKKPVEEVRCRTKHCPRWKTTTWSSCSVTCGRGIRRREVQCYRGRKNLVSDSECNPKTKLNSVANCFPVACPAYRWNVTPWSKCKDECARGQKQTRRVHCISTSGKRAAPRMCELARAPTSIRECDTSNCPYEWVPGDWQTCSKSCGEGVQTREVRCRRKINFNSTIPIIFMLEDEPAVPKEKCELFPKPNESQTCELNPCDSEFKWSFGPWGECSKNCGQGIRRRRVKCVANDGRRVERVKCTTKKPRRTQYCFERNCLPSTCQELKSQNVKAKDGNYTILLDGFTIEIYCHRMNSTIPKAYLNVNPRTNFAEVYGKKLIYPHTCPFNGDRNDSCHCSEDGDASAGLTRFNKVRIDLLNRKFHLADYTFAKREYGVHVPYGTAGDCYSMKDCPQGIFSIDLKSAGLKLVDDLNWEDQGHRTSSRIDRFYNNAKVIGHCGGFCGKCSPERYKGLIFEVNTKLLNHVKNGGHIDDELDDDGFSGDMD
Protein: Beta-taxilin (Muscle-derived protein 77) (hMDP77) (Q8N3L3)
Organism: Homo sapiens (Human)
Function: Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.
Interaction partners:
- Alpha-taxilin
- Syntaxin-1A
- Syntaxin-4
- Syntaxin-8
- Syntaxin-7
- Syntaxin-3
Sequence:
MEANHSEQLSAERQSTPPGDSSSLPSHNGLEKEDGQDSPTPVQPPEKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKEPEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQADQASWKPEAEASGQAPQAPTEASLQKMEADVPAPACAAEEHVAAMVPACEPSRQPPRAAAEELPVGASAGPQPRNVADTNLEGVD
Protein: Ammonium transporter Rh type B (Rhesus blood group family type B glycoprotein) (Rh family type B glycoprotein) (Rh type B glycoprotein) (Q7T070)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill (By similarity).
Subcellular location: Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Urea transporter
- Facilitated urea transporter
Sequence:
MAESTNLRLRLPLICIILEVILIILFGVLVEYNDDTDAKKWNKNNSTDPATNEFYYRYPSFQDVHVMIFVGFGFLMTFLQRYGFSSMGFNFLIAAFSLQWATLMQGFFHGMHHGKIHVGVTSMINADFCTGAVLISFGAVLGKTSPVQLLVMAILEVTLFAVNEYILLSILGANDAGGSMTIHTFGAYFGLMVTRILHRPNLDKSKHKNSSVYHSDLFAMIGTIFLWMFWPSFNSAITQYGDPQHRTAANTYYSLAACTLATFGFSSLVNPEGKLDMVHIQNAALAGGVAVGTAGEMMLTPFGSMIVGFLAGTISVLGYKYLTPFMESKLKIQDTCGIHNLHGMPGILGAIVGAVTAALASRDVYGNGLDKVFLEAADNSQWSAQTKGGFQAISLAVTLGIALIGGLITGFLLKLPIYGTPPDTQCFEDAVYWEVPGEEEDHHELNEVSTQNEVEKLNS
Protein: Large ribosomal subunit protein mL38 (54S ribosomal protein L35, mitochondrial) (O14341)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL15m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL16m
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein mL44
- Large ribosomal subunit protein uL3m
Sequence:
MKRVWPRIPTISNVCRARSIYSAAQENAYRSSVKLIQEYSEKVHKKLQAKLLENPSETSPEIERLQVLSQINLPEVRSKFHKKEIDYTNPVFLYMLKQQWEDYQKLLLLQRLEQMKVIKDSGIGSFSPSVDVQLGFNPENNDSITPGTILPSTVTVKTPWLSVLPFNCKKNHYSVITLDLDVPNYETNRFETHCNWLLTNIPIEASKRVPIDTSKAFFQYRPPIVHRGEDKHRILTLVLRQKSSSISIPSNALVRERFDLSEFCSIYDLEPVGAHLWRSGWDSDAVALLSKHPSVHEYRDIRVERIPA
Protein: Mitochondrial tRNA methylthiotransferase CDK5RAP1 (EC 2.8.4.3) (CDK5 activator-binding protein C42) (CDK5 regulatory subunit-associated protein 1) (mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase) (mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase) (Q9JLH6)
Organism: Rattus norvegicus (Rat)
Function: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (By similarity). Essential for efficient and highly accurate protein translation by the ribosome (By similarity). Specifically inhibits CDK5 activation by CDK5R1 (By similarity). Essential for efficient mitochondrial protein synthesis and respiratory chain (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q96SZ6}.
Interaction partners:
- Exosome complex component RRP40
- Exosome complex component RRP46
- tRNA dimethylallyltransferase
Sequence:
MHPLQRVFRAQRLSAPLTSMCWVLLRTFRAHNSTSCPDPEGKSSEGVQKDFSSRLATGPTFQHFLRSASVPQEKPSSPEVEDPPPYLSGDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKVLKAKRPRSRVPLRIGILGCMAERLKGEILNREKMVDLLAGPDAYRDLPRLLAVVESGQQAANVLLSLDETYADIMPVQTSPSATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPVASILDEVRKLSEQGLKEVTLLGQNVNSFRDNSEVQFSSTGSANLSRGFTTNYKPKQGGLRFSHLLDQVSRIDPEMRIRFTSPHPKDFPDEVLQLIRERHNICKQIHLPAQSGSSRVLEAMRRGYSREAYVALVHHIREAIPGVGLSSDFITGFCGETEDDHLQTVSLLREVQYNTGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITVFREEASKVNATSVGCTQLVLVEGFSKRSTTDLCGRNDANLKVIFPDAEVEDITDPGLKVRAQPGDYVLVKIISASSQTLKGHILCRTTMKDSSMNCLT
Protein: Secreted protein with altered thrombospondin repeat domain (O96207)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKKSRFLLLSIFFCFVTNISLEFKRKQKVEINSLQTNKNNDNIREEKIKGDVESQPDVDGDTCVIFSSSEGNSRNCWCPRGYILCSEEDVLDVQGKLNEIKNKHERSLVTPLWMKRLCDNSNDVGFKSMSVVIDYELAVLCKDGSNKDYADFEIIGASGYITGEEMIEEQKRNPWYVPRKCTVNNFYLCRKVENDNVNCSYTPWSDWSACKNNTQKRYRKVRRSNQNNENFCLWNDKIVPRNIMEQTRSC
Protein: Helix-loop-helix DNA-binding domain containing protein (Q2QMM0)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MAAWLYPIVGGHQVAAGGWLSPEAGDDRRAAPPAPEKKQMDNMPAVASPTMNKDEASDDSGERKKKKKKASSAAGKASRHRHAAGAHNLTEKRRRFKITERFRTLQRLVPGCDNKSNQASTLDQTIQYMKSLQHQLEATSAVGSPAAAVLYPAAVHPQSYMHPPAPPPPVAGAAAPVTMAPMPAGMVLAAAPPGAAPPPGPPATMMPFGAMLPYPPYPEVLLPPPPATLYGRPPAAAPSVAARRHGSTSGGGRISKSSSSSLRKEL
Protein: Plant cysteine oxidase 3 (AtPCO3) (EC 1.13.11.20) (NIFS-like protein 2) (NifS2) (Q1G3U6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the oxidation of N-terminal cysteine residues (N-Cys), thus preparing the protein for N-end rule pathway-mediated proteasomal degradation, upstream of the N-end rule enzymes ATE1, ATE2 and PRT6 (Probable). Controls the preparation of the group VII ethylene response factor (ERF-VII) proteins for degradation via the 26S proteasome N-end rule pathway (Probable). Acts as an oxygen sensor that controls the stability of ERF-VII proteins, which are stabilized in flooding-induced hypoxia, and regulate transcriptional adaptation to these adverse conditions (Probable).
Subcellular location: Nucleus {ECO:0000305|PubMed:24599061}. Cytoplasm {ECO:0000305|PubMed:24599061}.
Interaction partners:
- E3 ubiquitin-protein ligase PRT6
- Ethylene-responsive transcription factor RAP2-12
- Arginyl-tRNA--protein transferase 2
- Aminopeptidase
Sequence:
MLSRLFKAGEKVLSNLVSKKDIYMASRNQEKSPKVQELYDLCKETFTGKAPSPASMAIQKLCSVLDSVSPADVGLEEVSQDDDRGYGVSGVSRFNRVGRWAQPITFLDIHECDTFTMCIFCFPTSSVIPLHDHPEMAVFSKILYGSLHVKAYDWVEPPCIITQDKGVPGSLPARLAKLVSDKVITPQSEIPALYPKTGGNLHCFTALTPCAVLDILSPPYKESVGRSCSYYMDYPFSTFALENGMKKVDEGKEDEYAWLVQIDTPDDLHMRPGSYTGPTIRV
Protein: Melatonin-related receptor (G protein-coupled receptor 50) (H9) (O88495)
Organism: Mus musculus (Mouse)
Function: Does not bind melatonin.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19699797, ECO:0000269|PubMed:29572483}; Multi-pass membrane protein. Postsynaptic density {ECO:0000269|PubMed:19699797}.
Interaction partners:
- Melatonin receptor type 1B
- Melatonin receptor type 1A
Sequence:
MATVPKSNMGPTKAVPTPFGCIGCKLPKPDYPPALIIFMFCAMVITVVVDLIGNSMVILAVTKNKKLRNSGNIFVASLSVADMLVAIYPYPLMLYAMSVGGWDLSQLQCQMVGLVTGLSVVGSIFNITAIAINRYCYICHSLQYKRIFSLRNTCIYLVVTWVMTVLAVLPNMYIGTIEYDPRTYTCIFNYVNNPAFTVTIVCIHFVLPLIIVGYCYTKIWIKVLAARDPAGQNPDNQFAEVRNFLTMFVIFLLFAVCWCPVNVLTVLVAVIPKEMAGKIPNWLYLAAYCIAYFNSCLNAIIYGILNESFRREYWTIFHAMRHPILFISHLISDIRETWETRALTRARVRARDQVREQERARACVAVEGTPRNVRNVLLPGDASAPHSDRASVRPKPQTRSTSVYRKPASIHHKSISGHPKSASVYPKPASSVHCKPASVHFKPASVHFKGDSVYFKGDTVHYRAASKLVTSHRISAGPSTSHPTSMAGYIKSGTSHPATTTVDYLEPATTSHSVLTAVDLPEVSASHCLEMTSTGHLRADISASVLPSVPFELAATPPDTTAIPIASGDYRKVVLIDDDSDDSDCSDEMAV
Protein: Suppressor of tumorigenicity 14 protein homolog (EC 3.4.21.109) (Serine protease 14) (A0A8I6ARC9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MGNNRGRKAGGGSQDFGAGLKYNSRLENMNGFEEGVEFLPVNNAKQVEKRGPRRWVVMVAVVFSFLLLSLMAGLLVWHFHYRNVRIQKVFNGHLRITNENFLDAYENSTSTEFISLASQVKEAVSLVPGEVLCPACPSTGSVIAYYWSEFSIPPHLEEEVDRAMAVERVVTLPPRARALKSFVLTSVVAFPIDPRMLQRTQDNSCSFALHARGRTVTRFTTPGFPNSPYPAHARCQWVLRGDADSVLSLTFRSFDVAPCDGHDSDLVTVYDSLSPMEPHAVVRLCGTFSPSYNLTFLSSQNVFLVTLITNTDRRHPGFEATFFQLPKMSSCGGLLSEAQGTFSSPYYPGHYPPNINCTWNIKVPNNRNVKVRFKLFYLVDPNIPVGSCTKDYVEINGEKFCGERSQFVVSSNSSKITVHFHSDHSYTDTGFLAEYLSYDSNDPCPGMFMCKTGRCIRKDLRCDGWADCPDYSDERHCRCNATHQFMCKNQFCKPLFWVCDSVNDCGDGSDEEGCSCPAGSFKCSNGKCLPQSQQCNGKDDCGDGSDEASCDNVNAVSCTKYTYRCQNGLCLNKGNPECDGKKDCSDGSDEKNCDCGLRSFTKQARVVGGTNADEGEWPWQVSLHALGQGHLCGASLISPDWLVSAAHCFQDETIFKYSDHTMWTAFLGLLDQSKRSASGVQEHKLKRIITHPSFNDFTFDYDIALLELEKPAEYSTVVRPICLPDNTHVFPAGKAIWVTGWGHTKEGGTGALILQKGEIRVINQTTCEELLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEKDGRIFQAGVVSWGEGCAQRNKPGVYTRIPEVRDWIKEQTGV
Protein: Uncharacterized protein YDR391C (Q04170)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MSFENKLPTPLENNDAKGHMVCTLNKTTDARRAAETLSIAFSNSPAFHFICKKILNIPLAEKVPTRTITTDIISPFLDSPYGEISEVNTFDAVAVWSLPPHVPKARSNDAKFNKDFIDDLNARVKQVIPNGINYYYLFCIGKNLNEKGIRGSVRTIFEEYKRRADEENCAIVLEAIAEHAKSVYEYFGFRNYMTFKYGECEVDSNGNCDPNGEGFTAYLMIYHKDGNKVLKE
Protein: Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Q5SX39)
Organism: Mus musculus (Mouse)
Function: Muscle contraction.
Subcellular location: Cytoplasm, myofibril {ECO:0000269|PubMed:28752107}. Note=Thick filaments of the myofibrils.
Interaction partners:
- Myosin light chain 1/3, skeletal muscle isoform
- Myosin regulatory light chain 11
- Actin, alpha skeletal muscle
- Myosin-1
- Troponin C, skeletal muscle
- Alpha-actinin-3
- Troponin T, fast skeletal muscle
- Troponin I, fast skeletal muscle
- Myosin-2
- Tropomyosin alpha-1 chain
Sequence:
MSSDAEMAVFGEAAPYLRKSEKERIEAQNKPFDAKSSVFVVDAKESYVKATVQSREGGKVTAKTEGGATVTVKDDQVFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATDTAVDILGFSADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNSVGALAKSMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNTLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKAEAHFSLVHYAGTVDYNIIGWLDKNKDPLNETVVGLYQKSGLKTLAFLFSGGQAAEAEGGGGKKGGKKKGSSFQTVSALFRENLNKLMTNLKSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAVCRGYLMRVEFKKMMERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEDFEKAKEDLAKSEAKRKELEEKMVALMQEKNDLQLQVQAEADGLADAEERCDQLIKTKIQLEAKIKELTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDENIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNMETVSKAKGNLEKMCRTLEDQLSEVKTKEEEQQRLINELSTQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEESKAKNALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACAALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKIKKQIDQEKSELQASLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEAIRNLRNTQGMLKDTQLHLDDALRGQDDLKEQLAMVERRANLMQAEIEELRASLEQTERSRRVAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELENEVENEQKRNIEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKIQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE
Protein: Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (Q1G1M0)
Organism: Bifidobacterium breve
Interaction partners:
Sequence:
MARVVGIDLGTTNSCIATLEGGEPTVIVNAEGMRTTPSVVAFSKSGEILVGEVAKRQAVTNVDRTISSVKRHMGTDWTVDIDGKKWTPQEISAQILMKLKRDAEAYLGEPVTDAVITCPAYFNDAQRQATKDAGKIAGLNVLRIINEPTAAALAYGLEKGKEDERILVFDLGGGTFDVSLLEIGKDDDGFSTIQVQATNGDNHLGGDDWDQKVIDWLVGEVKNKYGVDLSKDKIALQRLKEAAEQAKKELSSSTSTSISMQYLAMTPDGTPVHLDETLTRAHFEEMTSDLLGRCRTPFNNVLHDAGISVSDIDHVVLVGGSTRMPAVKDLVKELTGGKEANQSVNPDEVVAVGAAVQSGVIKGDRKDVLLIDVTPLSLGIETKGGIMTKLIDRNTAIPTKRSEVFSTAEDNQPSVLIQVYQGEREFARDNKPLGTFELTGIAPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGKEQSMTITGGSGLPKDEIDRMVKEAEAHEAEDKQRKEDAETRNQAEAFAYSTEKLVNDNKDKLSDDIVKEVTDKVNALKEALKGDDTDKVKTAQGELMTSAQKIGQVLYAQQGAEGAAAGAGAAGASAGSASGSDDDTVEAEVVDDDDDKDNK
Protein: Proteasome regulatory non-ATP-ase subunit 11 (Q8WRU0)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MLHPQLVAGGANRAAPAEELRDTAETVQISSLALLKMLMHGRAGVPLEVMGLMIGELIDDYTVRVSDVFSMPQTATGQSVEAVDPEYQVHMLDKLSVVGRPEKVVGWYHSHPGFGCWLSGEDVMTASSYEQLTPRSVSVVIDPIQSVRGKVVIDAFRTTKDPHTGPRIMFQEPRQTTSNIGWLTRPSPIALTRGLDRDYYSLPITFRKKNHELALLLNVYKKGWQEGFRLENMTRFDRNTVREKMRALASLAVQSERFIVQGLDEDDVGNVGRANPIAHLQSESEGLINASLNQSIGAMINGVVF
Protein: FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (PPIase) (EC 5.2.1.8) (Histidine-rich protein) (Metallochaperone SlyD) (Rotamase) (Sensitivity to lysis protein D) (WHP) (P0A9K9)
Organism: Escherichia coli (strain K12)
Function: Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction. SlyD could be involved in Tat-dependent translocation, by binding to the Tat-type signal of folded proteins. The PPIase substrate specificity, carried out with synthetic peptides of the 'suc-Ala-Xaa-Pro-Phe-4NA' type (where Xaa is the AA tested), was found to be Phe > Ala > Leu.
Subcellular location: Cytoplasm.
Interaction partners:
- Hydrogenase maturation factor HypB
- Formate hydrogenlyase subunit 5
- Hydrogenase maturation factor HypA
- Putative electron transfer flavoprotein subunit YgcR
- Thioredoxin 1
- FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
- Trigger factor
- Small ribosomal subunit protein uS2
- Chaperone SurA
- Chaperone protein DnaK
Sequence:
MKVAKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLISGLETALEGHEVGDKFDVAVGANDAYGQYDENLVQRVPKDVFMGVDELQVGMRFLAETDQGPVPVEITAVEDDHVVVDGNHMLAGQNLKFNVEVVAIREATEEELAHGHVHGAHDHHHDHDHDGCCGGHGHDHGHEHGGEGCCGGKGNGGCGCH
Protein: Bone morphogenetic protein 7 (G3V6W8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Noggin
- Bone morphogenetic protein receptor type-2
- Activin receptor type-2B
- Bone morphogenetic protein receptor type-1A
- Serine/threonine-protein kinase receptor
- Activin receptor type-2A
- Activin receptor type-1
- Chordin
- Follistatin
- Bone morphogenetic protein 4
Sequence:
MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEESGPDGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFQITVYQVLQEHSGRESDLFLLDSRTIWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHLRSIRSTGGKQRSQNRSKTPKNQEALRMASVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPDTVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
Protein: Cation/H+ exchanger protein 1 (Si:dkey-180p18.2) (Type II CAX cation/proton exchanger) (Q5RH62)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- Synaptogyrin
Sequence:
MAQIKPTMSVDVESRRRRSTESSEPFLDHDPKGRRCSSQCDRLCVAGAYHEIPDTPSPCTSQYFGHYTPKCLSAHRHSMHARCPEDIWQEASIRTSIRAENEVEAHKVANNYKFGFRKWKSHVTERPIEDRSDVVKELYSELNYVKQLSGSLVTAGNIVYVLLFGWWISLFYFLVGLLMFFTIAGIPYGKLCLQLSGYFIWPFGKALQKSSSLVKRCCVKFPHCEAIPEEVDEVKEPLKESTPLLHSGPAVTAEIPVPAPPTKPTRYWCRLSTYVWLILGYPLLAVVHCLAMFLSWMMVFTIPVSKMNARTLSLILLMPPEQVKVRNVKKPQGCETRVLLCCYRAFNWYYYKYTVDGINVFAVNLLPLVIITLIIGYMDRENYFVSSEVKFATALISIIPLSYYIGMGIASISAQSNFAVGAVVNATFGSITEMAFYITALLQGQRAGSQCYAELVKSALTGTLLGCILFIPGLCMIIGGFKHSEQRFNSRSAGVSSALLFISVGGVFAPTLFSKAYGNFICEGCNNPPGNISKPFICNNCHYDLSENNRPLFLSHIEPLVYTVSVLLPAAYLVGLIFTLKTHSHIYDIHISDGHCHVISDHHAVAHWSRTRALVVLILATILMAACADLSTEHIKPIISNSSVSQYFIGVTIIAMVPELPEIVNGVQFALQNNISLSLEVGSCLAVQVCMLQIPLLILFNAFYDVGFVLIFSDLHLWASIFSVILVNYIFMDGKSDYFQGTALVVVYLILLALYFFAPAPLGC
Protein: (S)-canadine synthase (EC 1.14.19.68) ((S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming)) (Cytochrome P450 719A1) (Q948Y1)
Organism: Coptis japonica (Japanese goldthread)
Function: Involved in the last but one step of the biosynthesis of berberine, an antimicrobial benzylisoquinoline alkaloid. Converts (S)-tetrahydrocolumbamine (THC) to (S)-tetrahydroberberine (THB) also called (S)-canadine.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEMNPLLVCATVAIVFATTTIIRILFSSSSLPQMKWPSGPRKLPIIGNLHQLGDDVLHVALAKLAKVHGSVMTIWIGSWRPVIVISDIEKAWEVLVNKSADYGARDMPEITKIASASWHTISTSDAGSFWQNVRKGLQSGAMGPLNVAAQNQYQERDMKRLIKAMSDEAANNNGIVKPLDHIKKNTVRLLTRLIFGQAFDDNKFIESMHYEIEDIIRISGYARLAEAFYYAKYLPSHKKAEREAFLVKCRVEELVRPLLSSKPPTNSYLYFLLSQNFEEEVIIFCIFELYLLGVDSTSSTTTWALAYLIREQGAQEKLYQDIRMTLGDVDLVKIEDVNKLKYLQGVVKETMRMKPIAPLAIPHKTAKETTLMGTKVAKGTRIMVNLYALHHNQNIWPDPYKFMPERFLEGETGTAYNKAMEQSFLPFSAGMRICAGMDLGKLQFAFALANLVNAFKWSCVEEGKLPDMGEELSFVLLMKTPLEARIAGRNV
Protein: Septin-7 (Q4V8R9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000256|ARBA:ARBA00004629}. Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000256|ARBA:ARBA00004430}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Midbody {ECO:0000256|ARBA:ARBA00004214}.
Interaction partners:
Sequence:
KKNDRFLKQHLNINIMAQKNLEGYVGFASLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSGEYPGPSNRIKKTVQVEQSKVLMKEGGVQLLLSIVDTPGFGDAVDNSNCWQPVIDHIDSKFEDYLNAESRVNRRQMPDSRVHCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMREILEHKIKIYEFPETDDEEENKIVKTIKDRLPLAVVGSNTIIEANGKKVRGRQYPWGVAEVENGDHCDFTLLRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTCNGIDNNKAKGQLTKSPLAQMEEERREHVTKMKKMEMEMEQVFEMKVKEKVQKLKDSEGELQRRHEQMKKNLEAQHKELEERRRQFEEERSTWETQQRILEQQKMTLEKNKKKGKIF
Protein: HP1 and insulator partner protein 1, isoform B (M9PG82)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEQVSDSAVTTLESTQAEEPPPGVEKVETLELKTAALETLSESAGPTDLENELANLNGSEEGPGLDELSTLEREIAKLHNIRPPDAASEVKDSDTPIALADNGGLEPRQAPDEAKCRTPIIEEGNAASGNGQSSESPLEEVDLIALLKGTDTSHDQPTGEEKCTLEKALSELDGVGEDGDVGVTIEGEGQFEIMEIDDDEGESSSRKASPKVPASKPIKSNSLPSISKHKLSPEQARAVALEQMAGLKPKSRRKEPPAPPSVVAPIDIVSSLNDDWDDYDSEEDKSASALVTEVITLPSAHVVTKKPPLPVKKLSSPVKHSPNSAILLNNKISGVKVMLKTVSQKQLAASTGAAAEKTKPTVVVSPPKETEEHTTGFKRMRVIKRKIIWDPDVPETKKSFAQYASTKAACPAPTTPKTTVKSISPTTTTKKEVAPKKRSATPTARSTKAGTPVGGTERGPSPVKRRAQTPNTGLANGGTQKKKKVSEIDRLMGDEGAANMIHAVEHEQRELSGGEVSNKPLMRKRAMTITGRAARVAVEPTPPKKESAQSAAKRTPADSVFTKATANTSARKPRASDSWDYVYKQRASEESMIMRRRSNSSYSSNASVSRNSLDNRPGAANLSDDAGEGSDPSFKFVKPVSKSSQRGGEDTSSHTLANDMKANNGSELVCLHKVNKVAHLVIHTERGNFGHTYSKQLLEQLNDTLSSVARKGEFNTVLLTVEGPQFCQGIDCQELIQGSLEKRKDSASQLAVALKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGYALWHGHQRVSSEVHSRLFLMGERLFATELLESNSFVDKICKARNVNEMALAKAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGEQWVTADCLANFKRYLNDVDF