Protein: Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)] (Q75760)
Organism: Human immunodeficiency virus type 1 (HIV-1)
Subcellular location: Host cell membrane {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004578}. Virion membrane {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004650}. Virion membrane {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004563}.; SUBCELLULAR LOCATION: [Surface protein gp120]: Virion membrane {ECO:0000256|HAMAP-Rule:MF_04083}; Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_04083}. Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04083}; Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_04083}. Host endosome membrane {ECO:0000256|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000256|HAMAP-Rule:MF_04083}. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. {ECO:0000256|HAMAP-Rule:MF_04083}.; SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane {ECO:0000256|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000256|HAMAP-Rule:MF_04083}. Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000256|HAMAP-Rule:MF_04083}. Host endosome membrane {ECO:0000256|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000256|HAMAP-Rule:MF_04083}. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. {ECO:0000256|HAMAP-Rule:MF_04083}.
Interaction partners:
Sequence:
MRVKGIRKSYQYLWKGGTLLLGILMICSAVEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLENVTEHFNMWKNNMVEQMQEDIISLWDQSLKPCVKLTPLCVTLNCKDVNATNTTNDSEGTMERGEIKNCSFNITTSIRDEVQKEYALFYKLDVVPIDNNNTSYRLISCDTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKTFNGKGPCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPNNNTRKSIHIGPGRAFYTTGEIIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNNTEGSNNTEGNTITLPCRIKQIINMWQEVGKAMYAPPIRGQIRCSSNITGLLLTRDGGINENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGAVFLGFLGAAGSTMGAASMTLTVQARLLLSGIVQQQNNLLRAIEAQQRMLQLTVWGIKQLQARVLAVERYLGDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDRIWNNMTWMEWEREIDNYTSEIYTLIEESQNQQEKNEQELLELDKWASLWNWFDITKWLWYIKIFIMIVGGLVGLRLVFTVLSIVNRVRQGYSPLSFQTLLPAPRGPDRPEGIEEEGGERDRDRSGRLVNGFLALIWVDLRSLCLFSYHRLRDLLLTVTRIVELLGRRGWEVLKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRIIEALQRTYRAILHIPTRIRQGLERALL