wanglab/gogpt-training-data huggingface dataset:
Protein: FACT complex subunit SSRP1 (F1QEB4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus {ECO:0000256|RuleBase:RU364013}. Chromosome {ECO:0000256|RuleBase:RU364013}.
Interaction partners:
- FACT complex subunit
- RNA polymerase-associated protein LEO1
- Transcription elongation factor SPT6
- RNA polymerase-associated protein CTR9 homolog
- RTF1 homolog, Paf1/RNA polymerase II complex component.
- Transcription elongation factor SPT5
- Parafibromin
- Transcription elongation factor SPT4
- RNA polymerase II-associated factor 1 homolog
- Polymerase
Sequence:
MGDTLEFNDIHQEVKGSWNDGRLRFSKQTVVYKSHKTGKVDSIPAPDLSEAQWRRVCLGHGLKLATSTGHIYKYDGFKETDYEKISAFFKANYKVELEEKDMCVKGWNWGTAKFAGSLLSFDVSDSPVFEIPLSSVSQCATGKNEVTVEFHQNDDAEVSLMEVRFYVPPNTGDDGSDPVEAFAQNILSKADVIQATGDAVCIFKELQCLTPRGRYDIRIYPTFLHLHGKTFDYKIPYTTVLRLFLLPHKDQRQMFFVISLDPPIKQGQTRYHFLILLFSKDEDISLALNMSEDEVEKRYEGKLSKNMSGPLYEIVSRVMKALVNRKITVPGNFQGHSGSQCITCAYKASSGLLYPLERGFIYVHKPPVHLRFEEISCVNFARGTTTTRSFDFEIETKQNNQFTFSNIEREEYGKLFDFVNAKKLTIKNRGFKEGMKGAEDYSDSDEDQHDAYLERMKEEGKIREEGDGSDDSEGDSDESFNPGEEDDDVPEEYDSNASVSDSEGDDGDSEDEGKKKKVEKKPKKVVKEKKERKPRKEKKVKDAAAPKRPMSAYMLWLNGNRERIKSENPGISITEISKKAGEMWKQLGKDKKEEWDKKAEEAKRQYEKAMKEYKESGGGAAAATKEKKKKGGKVEAKKKSGGEKEKKKEGGNDSFKSKEFISSEESSSESDHDRGSKRKASDDDDEEEEAAASTPASSEEESGSD
Protein: Basic helix-loop-helix (BHLH) DNA-binding superfamily protein (F4I7Z3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVSPENTNWLSDYPLIEGAFSDQNPTFPWQIDGSATVRIGSYIWRSCYGCVITQLVFRCSCCDRDIGLLHKSILCFFFCLRFAYVPLFPKEVDESRSLPIAKGSVEVDGFLCDADVIKEPSSRKRIKTESCTGSNSKACREKQRRDRLNDKFTELSSVLEPGRTPKTDKVAIINDAIRMVNQARDEAQKLKDLNSSLQEKIKELKDEKNELRDEKQKLKVEKERIDQQLKAIKTQPQPQPCFLPNPQTLSQAQAPGSKLVPFTTYPGFAMWQFMPPAAVDTSQDHVLRPPVA
Protein: Virus envelope protein E25 (Protein E25) (Virus envelope protein AC94) (P41483)
Organism: Autographa californica nuclear polyhedrosis virus (AcMNPV)
Function: Plays a role in the production of infectious budded virion (BV) and occlusion-derived virion (ODV) formation.
Subcellular location: Virion membrane {ECO:0000269|PubMed:9108103}. Host nucleus {ECO:0000269|PubMed:9108103}. Note=Associated with the envelopes of virions present in the nucleus of infected cells, with the envelopes of virions in the process of being occluded and fully occluded virions. {ECO:0000269|PubMed:9108103}.
Interaction partners:
Sequence:
MWGIVLLIVLLILFYLYWTNALNFNSLTESSPSLGQSSDSVELDENKQLNVKLNNGRVANLRIAHGDNKLSQVYIAEKPLSIDDIVKEGSNKVGTNSVFLGTVYDYGIKSPNAASTSSNVTMTRGAANFDIKEFKSMFIVFKGVTPTKTVEDNGMLRFEVDNMIVCLIDPNTAPLSEREVRELRKSNCTLVYTRNAAAQQVLLENNFTVINAEQTAYLKNYKSYREMN
Protein: ABSCISIC ACID-INSENSITIVE 5-like protein 3 (Dc3 promoter-binding factor 4) (AtDPBF4) (Protein ENHANCED EM LEVEL) (bZIP transcription factor 12) (AtbZIP12) (Q9C5Q2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds to the embryo specification element and the ABA-responsive element (ABRE) of the Dc3 gene promoter and to the ABRE of the Em1 gene promoter. Could participate in abscisic acid-regulated gene expression during seed development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:15642716}.
Interaction partners:
- Serine/threonine-protein kinase SRK2E
- Basic leucine zipper 8
- Serine/threonine-protein kinase SRK2D
- Serine/threonine-protein kinase SRK2I
- Em-like protein GEA6
- B3 domain-containing transcription factor ABI3
- Magnesium dechelatase SGR1, chloroplastic
Sequence:
MGSIRGNIEEPISQSLTRQNSLYSLKLHEVQTHLGSSGKPLGSMNLDELLKTVLPPAEEGLVRQGSLTLPRDLSKKTVDEVWRDIQQDKNGNGTSTTTTHKQPTLGEITLEDLLLRAGVVTETVVPQENVVNIASNGQWVEYHHQPQQQQGFMTYPVCEMQDMVMMGGLSDTPQAPGRKRVAGEIVEKTVERRQKRMIKNRESAARSRARKQAYTHELEIKVSRLEEENEKLRRLKEVEKILPSEPPPDPKWKLRRTNSASL
Protein: Phosphotransferase (EC 2.7.1.-) (Q6FRL7)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- ATP-dependent 6-phosphofructokinase
- Glucose-6-phosphate isomerase
- ATP-dependent 6-phosphofructokinase
- phosphoglucomutase
- phosphoglucomutase
- phosphopentomutase
- Phosphomannomutase
- 6-phosphofructokinase
- Mannose-6-phosphate isomerase
- Fructose-bisphosphate aldolase
Sequence:
MVHLGPKKPPARKGSMVDMPKDLLDEIKKFEDMFSVDAATLQKVTKHFISELSKGLSKEGGNIPMIPAWVMENPTGKEKGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYKLPGPMRTTKDPEEIWSFIADSLETFIKEQFPEGCNETLPLGFTFSFPASQDKINQGVLQRWTKGFDIPNIEGHDVIPMLQKQIEKRNLPIDIVALINDTTGTLVASLYTDGETKMGVIFGTGVNGAYYDVVSDIPKLEGKLADDIPSSSLMAINCEYGSFDNEHVVLPRNKYDIAIDEESPRPGQQTFEKMSSGYYLGELLRLALLDLYNQGLIFKGQDVQKLKEAYIMDTSYPSRIEDDPFENLEDTDELFQADLGIQTTVQERKLIRRLCELIGTRSARLSVCGIAAICQKRGYETAHIAADGSVFNKYPGFQQRAAEGLRDIYGWKEDKPQNYPIVIVAAEDGSGAGAAIIAALAQKRIAEGKSLGVIGA
Protein: Uncharacterized protein (Q586V6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MKRERSFSNSPTLSAQKGESFPSLRSEDRSEFAAQQQVLFDILRRTSLAEQKDREICEWLDDAYVWVKECIENKNFSKGALTELRLLVLGVLHTLPWWRVFESRETMGLEVYSRDGYRHDMRKITRWHDRIKVGFERVCLLLMEQSVQAVRGVLEVAMKPFRIRSPVADGAQRMVPADTIMRLINAVAVNYDGTVVLDVLNTCVRFLVPRWRWGEKRHHTISIALFLHLALEAHIPLASPFSGGEISMLGHSANGSARCKEESKLGGCGYDTQQTSSRDASLCRSDGSSADAGSFASPSACHPQQQRHSTGLKAPFLSSSDADLSDASQSMRSGTDDALGGSISGRTSGVARLTDTFVQNNRMLLYRNELIQFVLQWLLDLELSLQAHDDEARAVAGQHKNPTQGWGADPNGSSTLPSFSQSEIRPSETVYLDILRSCTDLVFHRLAEDLIRQRSVGVCGSADWWRELLTFHLNSVLMVESPRCLIYLAPSLALLGGTEEATDMYRKFIVLVTKGYQPVQPNAGCSTRPAGSTRVRMAPPTVGHLLVPKAQRTRAALHVYPLFRFMREHIHNVEDIRKQLHKCLLLQLERQRVVLPSATSPSCLASPTSINPFAQVLFAQIAALSELLELDAAEEMMSQVSGCRALKVLLDTYLLPPETNASENGVNSPTAGISPHGGNELKDDVPGKKVRRRFDLVKMEKVGLLYPGLMNDCPWDWRVCQGHGQMKRF
Protein: PDGF- and VEGF-related factor 1, isoform B (PDGF/VEGF factor-1) (VEGF2-B ligand short isoform) (Q9BLX1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQHPLLILPVLLLVLIVSEAAAGSLVSPNNRQPSQRFFYAAATSSSSTQTKVRLLRQADDPSAAPGALEGSCCQGAAAEAGTPLTLPLSVSAELTNVTADYDVSGEMPSSKENFKRSIMKSTVRNATPASCSPQPTIVELKPPAEDEANYYYMPACTRISRCNGCCGSTLISCQPTEVEQVQLRVRKVDRAATSGRRPFTIITVEQHTQCRCDCRTKAEDCNVYQSYRKDLCRCECHNTDARDKCLEQAENKYWVDDNCTCVCRYNQSCTTGTVFDETQCKCTDPAAPIDVLDRKRFIVQAVQVDPDNTTLYSV
Protein: AvrRxo1-ORF1 (Q6TKR8)
Organism: Xanthomonas oryzae pv. oryzicola
Interaction partners:
Sequence:
MKNKTDIAGIAGLSTSHVSFDDAESKSVLDGSTQSTPEYKFQTPLDQLPARPAGPKSSNTTDAYIHESLPHSVPIAGASTSAVTHQQATQRKGTDEIYGLGSLPSAGPGRWEYLANPGNWHPERRKLHEKLLDQARSSALTLAESLESDGCQPTLFALRGNTATGKTRIATKKIPVLAAALKKTAGKGCVNPDVFKSSLAKSETGAKIFSSAQVHSESSFLADRFEGGLRSQKTGSGAIASIVVDKRLSREYEIDSYIQLAKETGRKVELCDIDAPLENSLVGVLQRKPEGEDPRPPYPVVSSGFVAVRSNRMYVIDRFIADPSLGNYRLFGTAEDGEKVMVASVIGGEFSVENAELYEKITSPQLSVTGDLADKVIDKELIDRLENNIADPERAAKTRAALEKYSGKSWSAALAAHSELI
Protein: CASP-like protein 3A1 (AtCASPL3A1) (Q3EB59)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:24920445}; Multi-pass membrane protein {ECO:0000269|PubMed:24920445}.
Interaction partners:
Sequence:
MAKAAEQKQNPTVASAEAKLDIRDVVNTAITYGEDNRHGGGKRNDVAMFVLRAMCMAVSTVAVTLMVTARETSMTTLYGFEFQLHAVWSLSDSLIYLVVVSSATVLYSLIQLIISGTRLMRKSPVIPTRTQAWFCFVADQIIGYAMVSGGSAALGVTNMNRTGIRHMPLPNFCKSLGFFCDHLAGSIVFALFAFLLLAASSLLDVLHLSRHR
Protein: RING finger protein ETP1 (BRAP2 homolog) (Ethanol tolerance protein 1) (P38748)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May act as a cytoplasmic retention protein with a role in regulating nuclear transport. Binds nuclear localization sequences in vitro. Needed to adapt efficiently to ethanol, either as sole carbon source or as cell stressor. Involved in ethanol-dependent transcriptional activation of several genes and ethanol-induced protein turnover of some proteins.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Ubiquitin-ribosomal protein eL40A fusion protein
Sequence:
MDQFEYIITLEFGNQNQVESAYQIFKSIPKKLKAKSIGEESIKSNNQDWQDWRVCDLEIDMITDFKNQTSKEEESDLITSQYLGHGIIRLFKLSNANNTLNEKEILTIPGDDTMICILFVPTYFTVHDLLHFYIGDDIVNKQVSNFRILRNQQKGMGFNFTVLIKFRNALDAKNFKEEFNGKSFSRMDPETCHVISVKEIVFQKKLFQRPAANEDFPYLLTDPFTVKKKKELVKVELPTCPVCLERMDSETTGLVTIPCQHTFHCQCLNKWKNSRCPVCRHSSLRLSRESLLKQAGDSAHCATCGSTDNLWICLICGNVGCGRYNSKHAIKHYEETLHCFAMDIRTQRVWDYAGDNYVHRLVQNEVDGKLVEVGGSGDDDNNDIGNSDELQNVVYGNRSKNGEKSNSNKKDGELAANFLRHREYHLEYVQVLISQLESQREYYELKLQEKDQTASDSSNVESLKKSMEDLKLQFQVTQKEWQKREMAQKSKLEEDMLVIEGLQANLDHLSKKQEQLERENKALEESKQDLEEQVKDLMFYLDSQEKFKDADESVKEGTILIQQPHGAAQASKSKKKRNKNKKAGK
Protein: Transmembrane protease serine 4 (EC 3.4.21.-) (Channel-activating protease 4) (mCAP2) [Cleaved into: Transmembrane protease serine 4 catalytic chain] (Q8VCA5)
Organism: Mus musculus (Mouse)
Function: Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (By similarity). Seems to be capable of activating ENaC.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9NRS4}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9NRS4}.; SUBCELLULAR LOCATION: [Transmembrane protease serine 4 catalytic chain]: Secreted {ECO:0000250|UniProtKB:Q9NRS4}. Note=Activated by cleavage and secreted. {ECO:0000250|UniProtKB:Q9NRS4}.
Interaction partners:
- Transmembrane protease serine 2
- Angiotensin-converting enzyme 2
- Transmembrane protease serine 11F
Sequence:
MESDSGQPLNNRDIVPFRKPRRPQETFKKVGIPIIAVLLSLIALVIVALLIKVILDKYYFICGSPLTFIQRGQLCDGHLDCASGEDEEHCVKDFPEKPGVAVRLSKDRSTLQVLDAATGTWASVCFDNFTEALAKTACRQMGYDSQPAFRAVEIRPDQNLPVAQVTGNSQELQVQNGSRSCLSGSLVSLRCLDCGKSLKTPRVVGGVEAPVDSWPWQVSIQYNKQHVCGGSILDPHWILTAAHCFRKYLDVSSWKVRAGSNILGNSPSLPVAKIFIAEPNPLYPKEKDIALVKLQMPLTFSGSVRPICLPFSDEVLVPATPVWVIGWGFTEENGGKMSDMLLQASVQVIDSTRCNAEDAYEGEVTAEMLCAGTPQGGKDTCQGDSGGPLMYHSDKWQVVGIVSWGHGCGGPSTPGVYTKVTAYLNWIYNVRKSEM
Protein: Ferruginol synthase (EC 1.14.14.175) (Cytochrome P450 76AH1) (S4UX02)
Organism: Salvia miltiorrhiza (Chinese sage)
Function: Cytochrome P450 enzyme (CYP) which catalyzes a unique two-electron oxidation cascade on abieta-8,11,13-triene to produce ferruginol, an intermediate in tanshinone biosynthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MDSFPLLAALFFIAATITFLSFRRRRNLPPGPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLPVASEWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWKLEDDSTAAADHAGELFGVAVRRAVPLRIIPIVKS
Protein: SWR1 complex bromodomain subunit bdf1 (Q9Y7N0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- RuvB-like helicase 1
- RuvB-like helicase 2
- Actin-like protein arp5
- Chromatin-remodeling ATPase INO80
- Probable actin-related protein 8
- Protein AF-9 homolog
- Actin
- Actin-related protein 4
- Helicase swr1
- INO80 complex subunit 1
Sequence:
MSSESRENEVKAETKDEIANDGSPQLNGDNNIQSSDGHNDENEESLSRKRDSSGATVGDLKQEEKESMPKKEPEPTVKKIRGSGMPPPQQKYCLAIVRQLKRTKNSAPFKVPVDPIKQNIPDYPTIVKNPMDLGTIEKKLTSYEYSVPQEFIDDMNLMFSNCFLYNGTESPVGSMGKALQEVFERQLKQLPDAEQPAAAPVKKSKQKSASTAPPRTRRNSSVSSTSASVAASTAPKAASPAVLPEGKPRRRKNNSQMRFCSTVLKELYKRQYESFAFPFYQPVDPVACDCPDYFDVIKEPMDLSTIQSKLNKNEYSTLEEFESDILLMFNNCFTYNPPGTPVHVMGRQLENVFKEKWEARPKFDDATLVKQQEAETDALFDNGEEEEALMSEEEINGAKFAAVDKQISMLQDTLEAMKAKKMNRMRKPRRRDLTKEYGPITYAMQNELAERCNYLSAEQLSNVAEILREEMPWLRDTDEIEIDVGNMKPEVFHRIYRYVCKPDADSSEPASPVLMPTKPEKKKGRVLSETEQAEKIRRLQQQLDRFAGKTSPTSPESNNAANVSDSESDNESESSESA
Protein: Aryl hydrocarbon receptor nuclear translocator homolog (ARNT) (AHR-associated protein) (O02219)
Organism: Caenorhabditis elegans
Function: Transcription factor. Efficient DNA binding requires dimerization with another bHLH protein, such as cky-1 or ahr-1. Regulates transcription of target genes, probably acting in complex with cky-1. Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11427734}. Note=Nuclear location dependent on hif-1 expression in intestinal tissue but not in neuronal cells. {ECO:0000269|PubMed:11427734}.
Interaction partners:
- Aryl hydrocarbon receptor protein 1
- Hypoxia-inducible factor 1
- PAS domain-containing protein cky-1
- Helix-loop-helix 34
- Period protein homolog lin-42
- Hypoxia-inducible factor prolyl hydroxylase
- Heat shock protein 90
- von Hippel-Lindau tumor suppressor homolog
- Nuclear hormone receptor family member nhr-23
- Protein timeless homolog
Sequence:
MAQDIFMDPWQSATSFAMEDEDMGMPSGKYARMEDEMGENKERFARENHSEIERRRRNKMTHYINELAEMVPQCASLGRKPDKLTILRMAVSHMKGIRGHTAQDETSYKPSFLTDQELKHLILEAANGFLFVVCCQTGKVLYVADSITPVLNLKQEDWLQRNLNELIHPDDQDKIRDQLCGSEVSVNKVLDLKSGSVKREGASTRVHMSCRRGFICRMRVGALEPLHRLRNRRPLFQHAGQNYVVMHCTGYIKNAPPQGINAPASSCLVAIARLQVASMPVCADPTSTNQFSVRVSEDGKMTFIDARVSDLIGLSSDQLIGRYWWNLAHPADEKTLQDSFVALLSDQPMRINIRVRTSTDYIPCTVSAYKFMNPYSEQFEYVVATHQIAPQEDINNWVTAPTVPQPQASEFGELGGAPSAVDYGQSSSGGWRPEAQGAPQAQWQWDPMNGYNQ
Protein: Erbb2 interacting protein (A0A8I6ACI5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTVVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNIRTFAADHNYLQQLPPEIGNWKNVTVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKGVKPSESITTKSKLDEREKYMNSVPKTSEPEAETNAGNSPVTTNRKSSGNMKHLVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDAKDTDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTALCSPAKQIPIDSNSKIRQEDENFNSLLQNGVNLNNSPEEKFKINDKKDFKLPEYDLNIEEQLVLIEKDVDSKATSEDSHQLDHINMNLNKLVTNNIFQPEIMERSKMQDIVLGTGFLSIHSKSEAEHIENGNKFLNSESINKVNGLSEDTAQSPGRIEPQNTSPADVGISKSTEDLSPQRSGPAGSVVKSHSITNMETGGLKIYDILSDDGPQPPGATVKVASTMDGKNIVRSKSATLLYDQPLQVFTASSSSSELLSGTKAVFKFDSNHNPEDPDIIRASIVPGPQSIPQLYGPPQYNVQYSGSAAMKDTLWHPKQNPQIDPVSFPPQRLPRSESAENHSYTKHSANMNFSNHNNVRANTAYHLHQRLAPTRHGEMWAVSPNDRLVPAVSRTTVQRQSSVSSTASVNLGDPGPTRRTEGDYLSYRELHSMGRTPVTSGSQRPLSARAFSIDGPSTSRPQSARPSISEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPHDWREQVLRHIEAKKLEKMPLSNGQMGQPLRPQANYSQTHHPPQASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFHNAVELIIVREVSS
Protein: Mitochondrial amidoxime-reducing component 1 (mARC1) (EC 1.7.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 1) (MOSC domain-containing protein 1) (Moco sulfurase C-terminal domain-containing protein 1) (Q5VT66)
Organism: Homo sapiens (Human)
Function: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:23086957}; Single-pass type II membrane protein {ECO:0000269|PubMed:23086957}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP.
Interaction partners:
- Cytochrome b5 type B
- NADH-cytochrome b5 reductase 3
Sequence:
MGAAGSSALARFVLLAQSRPGWLGVAALGLTAVALGAVAWRRAWPTRRRRLLQQVGTVAQLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVINQEGNMVTARQEPRLVLISLTCDGDTLTLSAAYTKDLLLPIKTPTTNAVHKCRVHGLEIEGRDCGEATAQWITSFLKSQPYRLVHFEPHMRPRRPHQIADLFRPKDQIAYSDTSPFLILSEASLADLNSRLEKKVKATNFRPNIVISGCDVYAEDSWDELLIGDVELKRVMACSRCILTTVDPDTGVMSRKEPLETLKSYRQCDPSERKLYGKSPLFGQYFVLENPGTIKVGDPVYLLGQ
Protein: Serpin family F member 1 (A0A8J8XL70)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MQTLVLLLWTGALLGHGSSQNVPDSSQDSPAPDSTGEPVVEEDDPFFKAPVNKLAAAVSNFGYDLYRLRSGAVSTGNILLSPLSVATALSGAEQRTESVIHRALYYDLINNPDIHSTYKELLASVTAPEKNFKSASRIVFERKLRVKSSFVAPLEKSYGTRPRILTGNPRIDLQEINNWVQAQMKGKIARSTREMPSALSILLLGVAYFKGQWATKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKLPLTGSMSIIFFLPLTVTQNLTMIEESLTSEFVHDIDRELKTIQAVLTVPKLKLSYEGDVTNSLQDMKLQSLFESPDFSKITGKPVKLTQVEHRAAFEWNEEGAGTSSNPDLQPVRLTFPLDYHLNRPFIFVLRDTDTGALLFIGRILDPSST
Protein: Regulator of steroidogenic factor-1 (Q9JIK3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
ENMMMKIAQKCNINLLPLPDPIPAGLMEECLDCDVEVKAAMHTYSSPSISTQSPKKQVQKPERAFQSQRTPGSHMPSPRNTSVSTLSAKSKHGKQKLPVKSHSECGILEKAAPPQELDCTTHPEEQVKNSVQTSTEDSSSNSQHQAKETSPGSLPKIPCLSSFKVHQPSALTFAELVEDYEHYIKEGLEKPVEIIRHYTGPGAQTVNPQNGFVRNRVSADRVQMLVSSSQSGDSESESDSCSSRTSSQSKGNKSYLEGSSDTQLKDSECTSVGGPLSLEQIQNGNDTSTQVEYQESPETQVKARHKEGANQRSKPSRRNPPRRSSYRVQTEAQEEGWHDCHRETNASSSDPYQDYEEYWRAYYRAWQEYYAAASHSYYWNAQRHPSWMAAYHMNTVYLQEMMRGNQ
Protein: Cryptic catabolic NAD-specific glutamate dehydrogenase GudB (NAD-GDH) (EC 1.4.1.2) (P50735)
Organism: Bacillus subtilis (strain 168)
Function: GudB seems to be intrinsically inactive, however spontaneous mutations removing a 9-bp direct repeat within the wild-type gudB sequence activated the GudB protein and allowed more-efficient utilization of amino acids of the glutamate family (called gutB1). This 3 amino acid insertion presumably causes severe destabilization of the fold of the protein, leading to an inactive enzyme that is very quickly degraded. The cryptic GudB serves as a buffer that may compensate for mutations in the rocG gene and that can also be decryptified for the utilization of glutamate as a single carbon source in the absence of arginine. It is unable to synthesize glutamate.
Interaction partners:
- Glutamate synthase large chain
- Glutamate synthase small chain
- Glutamine synthetase
- 1-pyrroline-5-carboxylate dehydrogenase
- Aspartate aminotransferase
- Isocitrate dehydrogenase
- 2-oxoglutarate dehydrogenase E1 component
- 2-oxoglutaramate amidase
- Putative aspartate aminotransferase YhdR
- Arginine biosynthesis bifunctional protein ArgJ
Sequence:
MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKEPMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSIWMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDVFTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKRGIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRDSFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTLEGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFNNIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI
Protein: G-protein coupled receptor BILF1 (GPCR BILF1) (P03208)
Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Function: Constitutively active, ligand-independent G protein-coupled receptor that has immunoevasive and oncogenic activities. Couples with the host inhibitory G protein (Gi) in order to disrupt the host chemokine signaling. As a consequence of its constitutive activity, mediates host CXCR4 inhibition. Enhances degradation of host major histocompatibility complex class I antigens via lysosomes, thereby modulating the antigen presentation to cytotoxic T cells. Targets selectively HLA-A, HLA-Band HLA-E molecules. Targets also newly synthesized MHC-I/peptide complexes en route to the host cell surface. Inhibits the host EIF2AK2/PKR phosphorylation. Displays tranforming activity.
Subcellular location: Host cell membrane {ECO:0000269|PubMed:15596846}; Multi-pass membrane protein {ECO:0000305}. Host mitochondrion outer membrane {ECO:0000269|PubMed:37311461}.
Interaction partners:
Sequence:
MLSTMAPGSTVGTLVANMTSVNATEDACTKSYSAFLSGMTSLLLVLLILLTLAGILFIIFVRKLVHRMDVWLIALLIELLLWVLGKMIQEFSSTGLCLLTQNMMFLGLMCSVWTHLGMALEKTLALFSRTPKRTSHRNVCLYLMGVFCLVLLLIIILLITMGPDANLNRGPNMCREGPTKGMHTAVQGLKAGCYLLAAVLIVLLTVIIIWKLLRTKFGRKPRLICNVTFTGLICAFSWFMLSLPLLFLGEAGSLGFDCTESLVARYYPGPAACLALLLIILYAWSFSHFMDSLKNQVTVTARYFRRVPSQST
Protein: Peroxiredoxin sll1621 (Prx) (EC 1.11.1.27) (Glutathione-dependent peroxiredoxin) (P73728)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Interaction partners:
- Thioredoxin
- Thioredoxin-like protein slr1139
- Putative peroxiredoxin sll0755
- Rehydrin
- Thioredoxin-like protein slr0233
- Slr1738 protein
- Slr0589 protein
- thioredoxin-dependent peroxiredoxin
- Hydroperoxy fatty acid reductase gpx1
- Thylakoid membrane protein slr1796
Sequence:
MTPERVPSVVFKTRVRDESVPGPNPYRWEDKTTEQIFGGKKVVLFSLPGAFTPTCSSNHLPRYEQLFEEFQALGVDDIICLSVNDAFVMFQWGKQIGADKVKLLPDGNGEFTRKMGMLVEKSNLGFGMRSWRYSMFVNDGKIEKMFIEPEFGDNCPVDPFECSDADTMLAYLKGAEAPGVSEPVKAFVG
Protein: Potassium voltage-gated channel subfamily H member 1b (K4EHU2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMYGELSDKETSEKLRQTFENYEMNSFELLMYKKNRMPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSSKGWGKFARLTRALTSSRGVLQQLAPTVQRGENVLKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCTFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNVTWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYVKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWLACIWYSIGDYEVIDQDANMVRTDSWLYLLGEAVGQPYHFNASGSGKWEGGPSKDSVYITSLYFTMTSLTSIGFGNIAPTTDGEKIFAVAMMMIGSLLYATIFGNVTNIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTDKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTIHSAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEVNLAQSCANVRALTYCDLHIIKRDALQKVLEFYTAFAGHFSRNLVLTYNLRKRIVFRKISDVKREEEEMLRRKNEAPLNLPPDHPVRRLFQRFRQQREARLAAERANQVEQDVEKGKSEQTVVKEITSPTSIITVTESPATLNTLSPTTPSTKTLCRAKLNTPLAPNTAQKSAEAPKSKGWSRFKEATAKSDLSLSSVSKAESMEMLPDRTKSQDELLSLKKTDSCDSGITKSDPRLDNMGSAGTPQDRSPVQPEDKRLFYTIPEHSLQACFSELRQDLQGDIHSLGCRMSALEGQLAEMLRLLAERNSSGPAELHHISRPNSPDSEKDDNISS
Protein: Nicotinamide N-methyltransferase (EC 2.1.1.1) (P34254)
Organism: Caenorhabditis elegans
Function: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions (By similarity). Involved in regulation of lifespan extension downstream of the sirtuin sir-2.1, probably through its role in nicotinic acid metabolism.
Interaction partners:
- Probable aldehyde oxidase gad-3
- NAD-dependent protein deacetylase sir-2.1
- Nicotinamide N-methyltransferase-like
- Purine nucleoside phosphorylase
- NAD-dependent protein deacylase sir-2.2
- NAD-dependent protein deacetylase sir-2.4
- NAD-dependent protein deacylase sir-2.3
- Leucine carboxyl methyltransferase 1
Sequence:
MTGTTENDNTGEDEKPKDEECAAIEHKDKFNPTAYLNSFYKTASEDTAMQIVLFFLPGILYRLPQKVRSVLDLGAGPTVYLPISLRDRAENIYTSDYAPANRDTLINWIEDKSDFDWDNVCSWIANIEASMETGKQMQNKTRKLMRAVLDVNVHESPVVQSIVWKENEQVQVPDKFQVVSTVFCLEYSCETLEAYFRAVRSACSLIDEGGILIQGGVLDATTYNFGGKTFRCHRLKQAHIIESLKANGMATTAEQGYKFITHDDIFLLVSKKL
Protein: J domain-containing protein spf31 (O74746)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Probable FAD synthase
Sequence:
MADVAKFLDRVEGSLNRGREIDRILSSFKLNAYDVLDILPGMSVDDIRNLYRKKSLMIHPDKNRDNPKAADAFDILKKAESDLVNDKIRESLDSAYTAARNQLLKEKKLSPNSEDVHSDQFLFDLKVRWREILIADEVARRRARQLDLANQQREQARQDEIARERKRRVESEKVWEETRDNRVGNWQDFLHKTKKNNLKKKNKKPRVLG