wanglab/gogpt-training-data huggingface dataset:
Protein: Condensin complex subunit 3 (CAPG homolog) (Q06680)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.
Subcellular location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Interaction partners:
- Condensin complex subunit 2
- Structural maintenance of chromosomes protein 2
- Condensin complex subunit 1
- Structural maintenance of chromosomes protein 4
- Structural maintenance of chromosomes protein 3
- Structural maintenance of chromosomes protein 1
- Sister chromatid cohesion protein PDS5
- Serine/threonine-protein kinase MPS1
- Structural maintenance of chromosomes protein 5
- Kinetochore protein NDC80
Sequence:
MQDPDGIDINTKIFNSVAEVFQKAQGSYAGHRKHIAVLKKIQSKAVEQGYEDAFNFWFDKLVTKILPLKKNEIIGDRIVKLVAAFIASLERELILAKKQNYKLTNDEEGIFSRFVDQFIRHVLRGVESPDKNVRFRVLQLLAVIMDNIGEIDESLFNLLILSLNKRIYDREPTVRIQAVFCLTKFQDEEQTEHLTELSDNEENFEATRTLVASIQNDPSAEVRRAAMLNLINDNNTRPYILERARDVNIVNRRLVYSRILKSMGRKCFDDIEPHIFDQLIEWGLEDRELSVRNACKRLIAHDWLNALDGDLIELLEKLDVSRSSVCVKAIEALFQSRPDILSKIKFPESIWKDFTVEIAFLFRAIYLYCLDNNITEMLEENFPEASKLSEHLNHYILLRYHHNDISNDSQSHFDYNTLEFIIEQLSIAAERYDYSDEVGRRSMLTVVRNMLALTTLSEPLIKIGIRVMKSLSINEKDFVTMAIEIINDIRDDDIEKQEQEEKIKSKKINRRNETSVDEEDENGTHNDEVNEDEEDDNISSFHSAVENLVQGNGNVSESDIINNLPPEKEASSATIVLCLTRSSYMLELVNTPLTENILIASLMDTLITPAVRNTAPNIRELGVKNLGLCCLLDVKLAIDNMYILGMCVSKGNASLKYIALQVIVDIFSVHGNTVVDGEGKVDSISLHKIFYKVLKNNGLPECQVIAAEGLCKLFLADVFTDDDLFETLVLSYFSPINSSNEALVQAFAFCIPVYCFSHPAHQQRMSRTAADILLRLCVLWDDLQSSVIPEVDREAMLKPNIIFQQLLFWTDPRNLVNQTGSTKKDTVQLTFLIDVLKIYAQIEKKEIKKMIITNINAIFLSSEQDYSTLKELLEYSDDIAENDNLDNVSKNALDKLRNNLNSLIEEINERSETQTKDENNTANDQYSSILGNSFNKSSNDTIEHAADITDGNNTELTKTTVNISAVDNTTEQSNSRKRTRSEAEQIDTSKNLENMSIQDTSTVAKNVSFVLPDEKSDAMSIDEEDKDSESFSEVC
Protein: Protein kinase, putative (Q387S6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYLKPYNNPYPVVSDRLEVILETMRKINGDSGSPVETPPERVPCIGSGAFATVRVGWVQERWHSQGKNEEPGQLTFGTTAAVAVKRVVVPGKLRSPLDGCRQRLLRELQVMEHIRICPHPNVVQCWGFVFYKAGDRASIGREVTDNLLGEVLTNFSQLREQQRVITGNMDKEKIGNEVLDGVSCFDVCLSLCTGGTLTEYVRRVADAALRATRTCIQERIVTQPKNTSMTDSTLGESPTGHNQGLTSSSSDAGIEPKGALLGLKTRKLTPIRKDVSGEFFTQKDSTLVVSHLTIREKDIVAIAYALCNALRHTHETLRTLHRDIKPANVLICDGIGKIPSYTSRATSCDFTARTTARARGAPTELENKKADGSKAVELVLFSDLRDALGNPQEGGSADDKLTPDVLVVPAEAGSHRVLCNSSDSPPYVLECLPQVDAWRLQLADYGIASGLDHMEASGRCGTFPFMAPEVEDEDCTGSTYGPKADIYSLGVTIQHVIVNATVEFNEVAQALPRRADALGRQWVDEEDRETSEVDNDSGTSGGVTDETKRKRTFNLPGNWRCKRELSDRDYVRDIYSHLSHPLPHDDCARSFTVPRSWRCHDELASGNCVEGLSTDGRTDTDNAGDKRGHLQPQNSDYRDNIKALNFRKGQGARCRSCGKLHRNLIELLNAMTAPDPSQRPTLSCILRDTAVIEQGTFVDEPRESSFPFSRSSSSSKHANAVANTSGRRNTTNSTACSPKQLSHTSRGTAPSPMAGRNHRSSCSGECKDQKTHDGSSEMFGGVNKYDGWREGVLWRPPSLKFLRRYSGQEGRC
Protein: AT4g02720/T10P11_1 (Ras-induced vulval development antagonist protein) (Q8S9I4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 7-dehydrocholesterol reductase-like protein
- Expressed protein
- Pre-mRNA-splicing factor SYF2
- Peptidyl-prolyl cis-trans isomerase CYP18-2
- At4g01000
- Protein COP1 SUPPRESSOR 2
- Serrate RNA effector molecule
- Protein XAP5 CIRCADIAN TIMEKEEPER
- At1g80930/F23A5_23
- Initiation factor eIF-4 gamma, MA3
Sequence:
MTMNSLPRRFGKNHGYLDRDYRNGRRSGSDSDEELKGLSHEEYRRQKRLKMRKSAKFCFWENTPSPPRDQNEDSDENADEIQDKNGGERDDNSKGKERKGKSDSESESDGLRSRKRKSKSSRSKRRRKRSYDSDSESEGSESDSEEEDRRRRRKSSSKRKKSRSSRSFRKKRSHRRKTKYSDSDESSDEDSKAEISASSSGEEEDTKSKSKRRKKSSDSSSKRSKGEKTKSGSDSDGTEEDSKMQVDETVKNTELELDEEELKKFKEMIELKKKSSAVDEEEEEGDVGPMPLPKAEGHISYGGALRPGEGDAIAQYVQQGKRIPRRGEVGLNAEEIQKFEDLGYVMSGSRHQRMNAIRIRKENQVYSAEDKRALAMFNYEEKAKREAKVMSDLQRLVQRHMGEEVGPNHDPFGAGKTEEDDD
Protein: SD08167p (Q8T3K2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDLDRRQTMPSTEVFNTIQFSSPLNRNGGLPDLRENDAKLQKEDYLRLDPDQEDDGCYEVPKTQGKPPSYDEALRSRPSPSDSPMSRNLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYGEDENEEEDRDEEQEGSSAPEPVYANQEATYGKLFEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEGAVGGVPLPQAVIEEFDPLSSKCSTLARSNKSNELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNARLLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSKTTPPIEGDSPPTYLEAIGGSKDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRKASFRGANQRQSDVRVALQMVPRPSLSPLLIRYEGPLVRFPSGVVEDILKEMQNRKAILRERQFQTFLDQEMKTPREMIPLDTITTLQCVSNSRVTDTATHFYCFEITTSQPKNGNGAGDAMSSNPNLLMTSSSSGNVKQQRVSHLYGVGKESERGVWMQKILESLTNSLPVKYTCHYYRAGWCYLKNSITSEWSGTWLVLRKSQRRLIFVSEANGNVEKMDLRKARCIVLKESDESIDNLHVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERLLGKLTDSFVFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPCSADEIKREQAMLACLQKYYAAAETLKDAVKQSGDIKIWISLNPNPENKTEEKTQVNATISPTKTAYELCREYSAKMQLPTHQLTLYEVILNDSLERPLHHDTKVFDVILNWSYWPEEDRKHNYLVVRPVEMLREIQRAVKNLATVTPGKELRFADSRTKTFKTLQCELRDGKIVVSKKDKNDKTTIVREIFLQSSTAYLGCERKRDFPWSWAITFVERTQAQIMRSRDAPFIGHVLAGSEWGDRTIWYSSIWYCLYRDNILPPAEIIIK
Protein: Zinc transporter 7 (Solute carrier family 30 member 7) (Q5MNV6)
Organism: Gallus gallus (Chicken)
Function: Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis (By similarity). Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8NEW0}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9JKN1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9JKN1}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q5BJM8}. Mitochondrion {ECO:0000250|UniProtKB:Q5BJM8}.
Interaction partners:
- Zinc transporter ZIP9
- Zinc transporter ZIP13
- Solute carrier family 30 member 9.
- Solute carrier family 39 member 11.
- Solute carrier family 39 member 12.
- Solute carrier family 39 member 10.
- Solute carrier family 39 member 14.
- Metallothionein
- RNA 3'-terminal phosphate cyclase.
- Leucine rich repeat containing 39.
Sequence:
MLPLSIKDDEYKPPRLNLFRKMSGWFRSILADKTSRNLFFFLCLNLSFAFVELLYGVWSNSLGLISDSFHMFFDCTALLAGLAASVISKWRSNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERALEPPDVHHERLLPVSILGFIVNLIGIFVFQHGGHGHSHGSGHEHSHSLFNGGLSHGHSHRGHGHSHEHKHGHTHDHGHSHGLSHGQDYCHDDHCLEGMTGSSKQILQGVFLHIVADTLGSIGVIISAILMQNYGLMIADPICSMLIALLIGVSIVPLLKESIGILMQRTPPSLENALPQCYQRVQQLQGVYSLHDPHFWTLCTDVYIGTLKLLVAPDADGRWILSQTHNIFTQAGVRQLYIQIDVAAM
Protein: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) (Cobalamin-independent methionine synthase) (Methionine synthase, vitamin-B12 independent isozyme) (Q9X112)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Interaction partners:
- S-adenosylmethionine synthase
- Adenosylhomocysteinase
- 5-methyltetrahydrofolate S-homocysteine methyltransferase
- Methionine--tRNA ligase
- O-acetyl-L-homoserine sulfhydrylase
- Aspartokinase II
- Cysteine synthase
- Threonine dehydratase catabolic
- Homoserine kinase
- Conserved hypothetical protein
Sequence:
MKAYAFGFPKIGEKREFKKALEDFWKGKITEEQFEEEMNKLRMYMVENYRKNVDVIPSNELSYYDFVLDTAVMVGAVPERFGEYRGLSTYFDMARGGKALEMTKFFNTNYHYLVPEIETEEFYLLENKPLEDYLFFKSKGIETAPWVIGPFTFLYLSKRNGEWIRRPNQMEKLLESLVSVYKEVFEKLVENGCKEILVNEPAFVCDLEKAHWDLILNVYRELSEFPLTVFTYYDSVSDYEACVSLPVKRLHFDFVSNEENLKNLEKHGFPEDKKLVAGVINGRQPWKVDLRKVASLVEKLGASAISNSCPLFHLPVTLELENNLPGGLKEKLAFAKEKLEELKMLKDFLEGKTFDLPNVSFEDFAVDLQAVERVRNLPEDSFRREKEYTERDRIQRERLNLPLFPTTTIGSFPQTPEVRKMRSKYRKGEISKEEYEAFIKEQIKKAIELQEEIGLDVLVHGEFERTDMVEFFAEKLNGIATTQNGWVLSYGSRCYRPPIIYGTVTRPEPMTLKEITYAQSLTEKPVKGMLTGPVTIMSWSYYREDIPEREIAYQIALAINEEVKDLEEAGIKIVQIDEPAFREKAPIKKSKWPEYFEWAINAFNLAANARPETQIHAHMCYSDFNEIIEYIHQLEFDVISIEASRSKGEIISAFENFKGWIKQIGVGVWDIHSPAVPSINEMREIVERVLRVLPKELIWINPDCGLKTRNWDEVIPSLRNMVALAKEMREKFES
Protein: Varicose (A1XXK0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVRWSARSRRQARQDKVELLARNNKVNGEDDTSDNAAFRNSTELSDHDEIFLKGLLGSSSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKA
Protein: Transgelin (Q9VZI1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- 39 kDa FK506-binding nuclear protein
- Ecdysone receptor
Sequence:
MASNRAAKSGFAAEAQRKINSKYSEELAQESLEWIKAVTEEPINTSGDTDNFFEVLKDGVILCKLANALQPGSIKKINESKMAFKCMENISAFLACAKNFGVPTQETFQSVDLWERQNLNSVVICLQSLGRKASNFNKPSIGPKEADKNVRNFSDEQLRAGANVISLQYGSNKGATQSGINFGNTRHM
Protein: Catalase (EC 1.11.1.6) (P55306)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Subcellular location: Peroxisome matrix {ECO:0000250|UniProtKB:P15202}.
Interaction partners:
- Glutathione peroxidase-like peroxiredoxin gpx1
- Cytosolic neutral trehalase
- Peroxiredoxin tpx1
- Mitogen-activated protein kinase sty1
- Uncharacterized protein C216.04c
- Heat shock protein hsp9
- Superoxide dismutase
- AP-1-like transcription factor
- Transcription factor atf1
- Superoxide dismutase, mitochondrial
Sequence:
MNSKDSNTVPVYTTNTGCPIFNPMAAARVGKGGPVLLQDSHLIDVFQHFDRERIPERVVHAKGSGAFGEFECTDDITKYTKHTMFSKVGKKTPMVARFSTVGGERGTPDTARDPRGFALKFYTDEGIFDMVGNNTPVFFLRDPAKFPLFIHTQKRNPQNDMKDATMFWDYLSQNAESIHQVMILFSDLGGTPYSYRFMDGFSSHTYKFVNDKGEFYYCKWHFITNQGTKGLTNEEAAALDGSNPDHARQDLFEAIERGDYPSWTLYVQVMTPQEAEKYRYNIFDLTKVWPHKDVPMQRVGRFTLNQNPTNFFADIEQAGFSPSHMVPGIEVSADPVLQVRTFSYPDTHRHRLGANFEQIPVNSPKCPVFNYSRDGPMNVNGNQGNWPNYPSSIRPLAKVQYEPDEGHEKWVGQVTYHMDEITDVDFEQPRAFWQNVLGKKPGQQDNFVKNVAGHLSGAISPVRERQYGVFTRVDSELGRRIREATEAEVKKMEEKAPKPINKGEPHMFQGSS
Protein: UPF0768 protein YBL029C-A (Q3E756)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cell membrane {ECO:0000269|PubMed:14562095}; Peripheral membrane protein {ECO:0000269|PubMed:14562095}. Note=Cell periphery.
Interaction partners:
- WD repeat-containing protein PAC11
- Dynein heavy chain, cytoplasmic
- Nucleoside diphosphate kinase
Sequence:
MSFIPIVCGMKSFDSSYDTVPGHQNLYCPNCHNYSVGPIKRKEFFTIWFIPLVPVFWGKQLHCPICNWRQDFKNDEQLNKVIQEQQNLRQKQPN
Protein: GPI transamidase component PIG-T homolog (O94380)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the GPI transamidase complex. Involved in transfer of GPI to proteins (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass type I membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- GPI-anchor transamidase
- GPI transamidase component gaa1
- GPI transamidase component PIG-S homolog
- GPI transamidase component GAB1 homolog
- GPI inositol-deacylase
- GPI ethanolamine phosphate transferase 3
- Alkaline phosphatase
- Mitochondrial 2-methylisocitrate lyase
- Mannose-6-phosphate isomerase
Sequence:
MKKNGCLLLFAYSLLSFSLTAATIDETYDESLFIKSFSSRYSYVSFAFEIGASTDSTHSSVFSESSFSLFPLSIARVMDECQVSELHIRATRGRWDYENWKESPDNGFYSGGLGFEVWAFMANDPSMKYWLKLTNQLSGLLCASLNYIDSSNTYQPQLSYPGSFSFSNNTQYFASLPQEDVCTENLSPLFKLLPCKRKAGIASLLDSHLFFDTDWHSFSIDVYPSENQSLASVKMGIIIQAVVDVERNGRRKGKTTFQPPSEYCHDEDMDSLHCLMSGYSTEHHTVDDLFHKVPKERCLLSSTFSDVFVSNGDKIDTFSLDEAANIQIPIQSTSDNHTVTVDRSLSNDGNHWGSLSSTIYNPSSSPRTIVYFEKFPWFVRVYLHTLTITLNGTRINTKDFIEKLYYQPLRDRKAGTMMEIQFSIPPHTNLIVHFNVEKTPLRLDEYPPDANRGYNLPPAIISVFDENNTKLCSLRTAALLMFIPTPDFSMPYNVIIFTSTVIALTFGGIFNLLTRRFVPQQSKFQNRQPSMLQRLKEKIFHKKRG
Protein: Alpha-amylase 2B (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase 2B) (Carcinoid alpha-amylase) (P19961)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Maltase-glucoamylase
- Probable maltase-glucoamylase 2 pseudogene)
- Sucrase-isomaltase, intestinal
- 1,4-alpha-glucan-branching enzyme
- Glycogen phosphorylase, brain form
- Glycogen phosphorylase, muscle form
- Glycogen phosphorylase, liver form
- Glycogen debranching enzyme
- Pancreatic alpha-amylase
- Lysosomal alpha-glucosidase
Sequence:
MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMSGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLVGLLDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWTFSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL
Protein: 26S proteasome regulatory complex subunit p42D (Q9U7A2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPDNLRVKALSEYRKKLLEHKEIEGRLKEKREEIKDLTKLYDKSENDLKALQSVGQIVGEVLKQLTEDKFIVKATNGPRYVVGCRRQLDKAKLKSGTRVALDMTTLTIMRYLPREVDPLVYNMSHEAPGDVTYSAIGGLTDQIRELREVIELPLLNPELFLRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFLKVVSSAIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDSLGQVKMIMATNRPDTLDPALLRPGRLDRKIEIPLPNEQARLEILKIHALKIAKHGEIDYEAIVKLSDNFNGADLRNVCTEAGFFAIRAEREYVIQEDFMKAVRKVSDNKKLESKLDYKPV
Protein: Epididymis secretory sperm binding protein (Tumor necrosis factor ligand 7A) (A0A0U5J7Q1)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
Protein: Sperm flagellar protein 1 (Q0IH24)
Organism: Xenopus laevis (African clawed frog)
Function: Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium. Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities (By similarity). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19767740}. Apical cell membrane {ECO:0000269|PubMed:29514918}. Note=Also found at the apical tip of cilia. {ECO:0000269|PubMed:19767740}.
Interaction partners:
Sequence:
MAVEFDEETMQELYTWVDTIPLSRPKRNIARDFSDGVLTAELVKFYFPKLVEMHNYVPANSTTQKLSNWTILNRKVLSKLSFSVPDDVIRKIVQCSPGVVELVLNTLRQKIEEKQRLHHISADLSQDQATQNNGNTHSDKGYKSNGTELSPRQGARVDPASKTHQGYAQAANADTTLRFQLAEKEQTLILSQETIQILQAKLRRLEQLLLLKNVRIDDLTRRLQELEKK
Protein: DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) (Q8IYB7)
Organism: Homo sapiens (Human)
Function: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24141620}. Cytoplasm, P-body.
Interaction partners:
- Exosome complex component 10
- Exosome complex component RRP41
- Exosome complex component RRP46
- Exosome complex component RRP40
- Exosome complex component CSL4
- Exosome complex component RRP45
- Exosome complex component RRP43
- Nuclear nucleic acid-binding protein C1D
- Exosome complex component RRP42
- Exosome complex component RRP4
Sequence:
MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPEQALLRRHPPPQTRMLSDLVEFCDQMGLPVDFSSAGALNKSLTQTFGDDKYSLARKEVLTNMCSRPMQMALYFCSGLLQDPAQFRHYALNVPLYTHFTSPIRRFADVLVHRLLAAALGYRERLDMAPDTLQKQADHCNDRRMASKRVQELSTSLFFAVLVKESGPLESEAMVMGILKQAFDVLVLRYGVQKRIYCNALALRSHHFQKVGKKPELTLVWEPEDMEQEPAQQVITIFSLVEVVLQAESTALKYSAILKRPGTQGHLGPEKEEEESDGEPEDSSTS
Protein: Sphingomyelin phosphodiesterase (EC 3.1.4.12) (Q5XIA6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Sphingomyelin phosphodiesterase 2
- Phosphatidylcholine:ceramide cholinephosphotransferase 2
- Sphingomyelin phosphodiesterase 3
- Glucosylceramidase
- Ceramide kinase
- Ceramide glucosyltransferase
- Sphingomyelin phosphodiesterase 4
- Ceramide synthase 5
- Galactocerebrosidase
Sequence:
MPHHGASSGQGHLRAGWEQRLERSLPAPKLGLLWMGLGLALVLALFDSTVLWVPARAYPLPSQGHSVKFSAVAPQLQNAFGWRNLTCPACKVLFTALNYGLKKEPNVARVGSVAIKMCKMLNIAPLNVCQSAVHLFEDDVVDVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHDYLEGTDPNCADPLCCRRGSGWPPNSRTGAGYWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRALNTITDLVWKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVDELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLGPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAPGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRADEQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPNGSLPDAHSLWSRPLLC
Protein: Nucleoporin NUP170 (Nuclear pore protein NUP170) (G0S7B6)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P38181}. Nucleus membrane {ECO:0000250|UniProtKB:P38181}; Peripheral membrane protein {ECO:0000250|UniProtKB:P38181}; Cytoplasmic side {ECO:0000250|UniProtKB:P38181}. Nucleus membrane {ECO:0000250|UniProtKB:P38181}; Peripheral membrane protein {ECO:0000250|UniProtKB:P38181}; Nucleoplasmic side {ECO:0000250|UniProtKB:P38181}. Note=Symmetric distribution. {ECO:0000250|UniProtKB:P38181}.
Interaction partners:
- Nucleoporin NIC96
- Nucleoporin NUP145
- Nucleoporin NUP152
- Nucleoporin NUP49
- Nucleoporin NUP192
- Nucleoporin NUP57
- Nucleoporin SEH1
- Nucleoporin NUP84
- Nucleoporin NUP133
- Nucleoporin NUP159
Sequence:
MEPMTPMRPIPGAYVNTPAPPTANPARRRLFTEASSSGAAATTQLGAAPAPLASTMAPGPEINSGLMTPQAREDLPPVAKAAQVVNQTLQLDDSYPDLDSYCRPGASSDYEMQSSDSSWAPFHVVRHHNIPDKVFEHLNAGEVFTKLGLFAEIGYAWASIDSSLFLWDYTHPNPELIGYEEATHTITAVALVPPKPGVFVKTITHVLVVATTSEIILLGVSATPTPSGSKSLTLYSTRMSVHRGGSDVSFIVGTKDGRIFLGGESDTDIHEIFYQQEERWFSSRCGKINHSHPGWSAVVPSLAGLPFGSRQQEWLRGLYVDDTRNLLYSLSNRSTIRTYHMEGPEKLTKVIEKDKTSCLRDFAHMADSSPLFTDKTNIVALSPIPATEASKLHLMALTDTGCRLFLSATSSASYTMGGATSLAPQSMQLQFVKFPPRESPTRIRTLNGQIIDSQLDKTSRALDPSALGFRFSPGYFFDVVRKHPNQDMLFVSAPDTGRIKVTQPASALKYFEQGTWIELENGNRTIEIGLTTAPFAAAKQPLGFGNELAVQFDQVPGEFAVLTNTGVHIVRRRRLVDIFAKALGNCVSASDDALEREVRKFINQYGRVETIAAALAVACGQGSDLRTGTGRGMDRNTENLARAAFIEYGGQPRLAESDGKQSVSESVRLSSRHDALALYLTRLVRTLWKAKVVQVGSGSDISSTIPTSKLVTIQENVERLRNFLEANKSTIQGLAPPSERLFGRQEDIANQKEHQALHALQKLMESISEGISFVLMLFDERVSDIYARLDAVSQQQLKDLTYEQLFSQTPGKELAKVLVKAIVNRNIASGANVETVADALRRRCGSFCSPDDVVTFKAQEQLQRASEQAHNSPVLRALLAESLRLFEQVAGSLTPANLTTAVEQYISLKYYAGAIQLCLTVAQQKDRGNTALSWVNDGKPANDSRKKAFDERKICYNLIHQVLDKLESDFAGEPELVDGRPTLAATKRMEAYNVVNDSSDEVFHFDLYEWYIEKGWTDRILSIDSPHVITYLQRLAETDFRHAELLCRFYTTRSRFFEAAQVQTNLAKSDLNISLKDRIILLSRAKGNASVNTIGISRQQQQQLNHEASELLEIAHIQDDLLERLVADPRIPEERKAEIEEFLDGPIRTLTDLFNDYADQANYYDLCLLIFHAADFHNPRTILDTWNNLINQSHFEAEQRREYWEIVQAGGDLPAGVIAPIAEPPLPYVYVSQQIQLIAHRTSLDSLIFPVNSLLPVVCAYAINNGQDASIGADPCWPIQLFLNLGVPHALVVQVLENVLDTQEAPFTGRRRKLVVQWIAMAVDMWVREVERRGAMAAAAASGASGSEAVMGSWVSELLGRADQVLTQIAGTGATLRGGAASDAEEIASLRRTVKGLKRSVDMLLGGEMARMSFFR
Protein: RNA polymerase III subunit E, isoform C (E1JI58)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRTMPAHPHQIPVFLSKNLRDSLYLFQYPTKTELPNHDDSVIVNCCVKPIAQEVKVDFGLDIESAHFDRFKGEQFAVAADGKNTYGAVPPKGQERPTYKRGIMDKQAFTSSRSITDVAKYIVGIFTDREVHLSPLTSIVQMRPVLSHFDKDDKRKKAELKAQTEDTDDDEVLQQVTVKFARGNAKNSGKEQRVGTYDSFVQRIADEPWCEAYWHSRGTPTAELERQKLFATSHHGSSSLALAPDEYLRKLLPYDEHVQTVAPAAASAAAQVLPVYNKAMLKSMPLLEQLTVLLRDARMLSFSDVISILAEHVDPHVAADKVLALLPQVGILLHGNWVPKSEVVFPEKVLSHANGVSAEQMIRARDYILFRFSRTPYLFRAQVMAATQLPPAETLDVLKTVARVNNTKRWELLLPPDKEFEQKYPELVSRQEYHWTASEQHYNEMDWARETKRVRKRSTRKSESQSLTSAMPPPAMNHSTTGSVDA
Protein: Methyl-accepting chemotaxis protein II (MCP-II) (Aspartate chemoreceptor protein) (P07017)
Organism: Escherichia coli (strain K12)
Function: Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar also mediates taxis to the attractant maltose via an interaction with the periplasmic maltose binding protein. Tar mediates taxis away from the repellents cobalt and nickel.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:22380631}; Multi-pass membrane protein {ECO:0000269|PubMed:22380631}. Note=Found predominantly at cell poles.
Interaction partners:
- Chemotaxis protein CheY
- Chemotaxis protein CheA
- Chemotaxis protein methyltransferase
- Chemotaxis protein CheW
- Protein-glutamate methylesterase/protein-glutamine glutaminase
- Protein phosphatase CheZ
- Methyl-accepting chemotaxis protein IV
- Motility protein A
- Motility protein B
- Flagellar secretion chaperone FliS
Sequence:
MINRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSNQQSNAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLAASPLTNKPQTPSRPASEQPPAQPRLRIAEQDPNWETF
Protein: Centrin, putative (Q38AA2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA-repair protein, putative
Sequence:
MDGDDGSRMGMPRLPPELTDAQRADIKEVFSILDVDGTETITPNDLKVALRALGYEPHKDTIKRLVAEMDRSGVSSNLILPEFEAILRAKLFTDDKEEVMLTFPHFTQGKSDYITLEDLKRVTQELGEDIPEDVLKRMIEEADVLDHDNRVSKEEFVRMLLTPKK