wanglab/gogpt-training-data huggingface dataset:
Protein: Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit] (O35298)
Organism: Mus musculus (Mouse)
Function: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses. In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria.
Subcellular location: Secreted {ECO:0000269|PubMed:15155618}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P28039}. Note=Detected in urine. {ECO:0000269|PubMed:15155618}.
Interaction partners:
Sequence:
MKFPWKVFKTTLLLLLLSHSLASVPSEDQPGDSYSHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEAMKADVVCYALEFCKRGAVQPQCHLYPLPQEAWESALEKARQVLRRSSTMKYPRSGRNICSLPFLTKICQKIELSIKKAVPFKDIDSDKHSVFPTLRGYHWRGRDCNDSDKTVYPGRRPDNWDIHQDSNCNGIWGIDPKDGIPYEKKFCEGSQPRGIILLGDSAGAHFHIPPEWLTASQMSVNSFLNLPSALTDELNWPQLSGVTGFLDSTSGIEEKSIYHRLRKRNHCNHRDYQSISKNGASSRNLKNFIESLSRNQASDHPAIVLYAMIGNDVCNSKADTVPEMTTPEQMYANVMQTLTHLNSHLPNGSHVILYGLPDGTFLWDSLHNRYHPLGQLNKDVTYAQFFSFLRCLQLNPCNGWMSSNKTLRTLTSERAEQLSNTLKKIATTETFANFDLFYVDFAFHEIIEDWQKRGGQPWQLIEPVDGFHPNEVASLLQANRVWEKIQLQWPHVLGKENPFNSQIEEVFGDQGGH
Protein: Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 1) (DAHP synthase 1) (Phospho-2-keto-3-deoxyheptonate aldolase 1) (P29976)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- 3-dehydroquinate synthase, chloroplastic
- Phospho-2-dehydro-3-deoxyheptonate aldolase
- Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic
- Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic
- 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Transketolase-1, chloroplastic
- Transketolase-2, chloroplastic
- Shikimate kinase 2, chloroplastic
- Shikimate kinase 1, chloroplastic
Sequence:
MALSNASSLSTRSIYGGDLSHRPSNRQSSFTFHPAVNTKPKSVNLVTAVHAAEPARNAVSVKESVASSSSGALKWTPESWKLKKALQLPDYPNANELESVLKTIEAFPPIVFAGEARNLEERLADAAVGKAFLLQGGDCAESFKEFNATNIRDTFRVLLQMSIVLTFGGQVPVIKVGRMAGQFAKPRSDAFEEKDGVKLPSYKGDNINGDTFDEKSRIPDPNRMIRAYTQSAATLNLLRAFATGGYAAIQRVTQWNLDFVEQSEQADRYQELANRVDEALGFMSACGLGTDHPLMTTTDFYTSHECLLLPYEQSLTRLDSTSGLYYDCSAHMVWCGERTRQLDGAHVEFLRGIANPLGIKVSNKMDPFELVKLVEILNPNNKPGRITVIVRMGAENMRVKLPHLIRAVRRSGQIVTWVCDPMHGNTIKAPCGLKTRAFDSILAEVRAFLDVHEQEGSHAGGIHLEMTGQNVTECIGGSRTVTYDDLSSRYHTHCDPRLNASQSLELAFIVAERLRKRRTGSQRVS
Protein: Acid-sensing ion channel 4 (A0A060DAJ9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPIEFVCKIKFAEEDEKQKGKQDGDKESLIEESCTPPAKDLVGFANSSSLHGINHIFVSGRLGIRQTLWALALLASLALFLYQAAKCAISYLEHPHVTALNEEASPEMVFPAVTICNINRFRFSALTDADIYHLANLTGLPPKNREGHKPTDLDYPAPDMQDIFNRTGHQLDEMLKSCNFSGQNCSAEDFSVVYTRYGKCYTFNGNKSTSRKTKQGGMGNGLEIMLDIQQDEYLPIWKETNETSLEAGIRVQIHSQDEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRSTSDQMIPGYDTYSISACRLRCETREVLRECNCRMVHMPGTADICTPSNIKCVDKALALLQKSTGDSCPCETPCNLTRYGKELSMVKIPSKGSARYLSRKYDKSEEYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASILSILEILDYVYEVIKHRLQRLLRPQKDEKKQQTATVATVDLQDMKANKESSDMTRSHPEGAYANTILPNHHLPHHQGQPHGMFEDFAC
Protein: Surface protein adhesin (C9E3B4)
Organism: Streptococcus mutans
Interaction partners:
Sequence:
MKVKKTYGFRKSKISKTLCGAVLGTVAAVSVAGQKVFADETTTTSDVDTKVVGTQTGNPATNLPEAQGSASKEAEQSQNQAGETNGSIPVEVPKTDLDQAAKDAKSAGVNVVQDADVNKGTVKTAEEAVQKETEIKEDYTKQAEDIKKTTDQYKSDVAAHEAEVAKIKAKNQATKEQYEKDMAAHKAEVERINAANAASKTAYEAKLAQYQADLAAVQKTNAANQAAYQKALAAYQAELKRVQEANAAAKAAYDTAVAANNIKNTEIAAANEEIRKRNATAKAEYETKLAQYQAELKRVQEANAANEADYQAKLTAYQTELARVQKANADAKATYEAAVAANNAKNAALTAENTAIKQRNENAKATYEAALKQYEADLAAVKKANAANEADYQAKLTAYQTELARVQKANADAKAAYEAAVAANNAANAALTAENTAIKKRNADAKADYEAKLAKYQADLAKYQKDLADYPVKLKAYEDEQTSIKAALAELEKHKNEDGNLTEPSAQNLVYDLEPNANLSLTTDGKFLKASAVDDAFSKSTSKAKYDQKILQLDDLDITNLEQSNDVASSMELYGNFGDKAGWSTTVSNNSQVKWGSVLLERGQSATATYTNLQNSYCNGKKISKIVYKYTVDPKSKFQGQKVWLGIFTDPTLGVFASAYTGQVEKNTSIFIKNEFTFYDEDGKPINFDNALLSVASLNREHNSIEMAKDYSGKFVKISGSSIGEKNGMIYATDTLNFKQGEGGSRWTMYKNSQAGSGWDSSDAPNSWYGAGAIKMSGPNNYVTVGATSATNVMPVSDMPVVPGKDNTDGKKPNIWYSLNGKIRAVNVPKVTKEKPTPPVKPTAPTKPTYETEKPLKPAPVAPNYEKEPTPPTRTPDQAEPNKPTPPTYETEKPLEPAPVEPSYEAEPTPPTRAPDQAEPNKPTPPTYETEKPLEPAPVEPSYEAEPTPPTPTPDQPEPNKPVEPTYEVIPTPPTDPVYQDLPTPPSVPTVHFHYFKLAVQPQVNKEIRNNNDINIDRTLVAKQSVVKFQLKTADLPAGRDETTSFVLVDPLPSGYQFNPEATKAASPGFDVTYDNATNTVTFKATAATLATFNADLTKSVATIYPTVVGQVLNDGATYKNNFTLTVNDAYGIKSNVVRVTTPGKPNDPDNPNNNYIKPTKVNKNENGVVIDGKTVLAGSTNYYELTWDLDQYKNDRSSADTIQKGFYYVDDYPEEALELRQDLVKITDANGNEVTGVSVDNYTNLEAAPQEIRDVLSKAGIRPKGAFQIFRADNPREFYDTYVKTGIDLKIVSPMVVKKQMGQTGGSYENQAYQIDFGNGYASNIVINNVPKINPKKDVTLTLDPADTNNVDGQTIPLNTVFNYRLIGGIIPANHSEELFKYNFYDDYDQTGDHYTGQYKVFAKVDITLKNGVIIKSGTELTQYTTAEVDTTKGAITIKFKEAFLRSVSIDSAFQAESYIQMKRIAVGTFENTYINTVNGVTYSSNTVKTTTPEDPADPTDPQDPSSPRTSTVINYKPQSTAYQPSSVQETLPNTGVTNNAYMPLLGIIGLVTSFSLLGLKAKKD
Protein: Toxin RelK (EC 3.1.-.-) (Endoribonuclease YoeB) (Putative mRNA interferase RelE3) (Putative mRNA interferase YoeB) (Toxin YoeB) (P9WF09)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriostatic rather than bacteriocidal fashion. Its toxic effect is neutralized by coexpression with antitoxin RelJ (shown only for M.smegmatis). Overexpression also increases the number of rifampcin-tolerant persister cells.
Interaction partners:
- Antitoxin RelJ
- Antitoxin RelB
- Antitoxin RelF
- Toxin RelE
- Toxin RelG
- Putative antitoxin Rv0268c
- Antitoxin Rv0298
Sequence:
MRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLKARYHY
Protein: Beta-amyrin synthase 1 (KsBAS1) (EC 5.4.99.39) (A0A0S2IHL6)
Organism: Kalopanax septemlobus (Castor aralia) (Acanthopanax septemlobus)
Function: Component of the oleanane-type triterpene saponins biosynthetic pathway. Oxidosqualene cyclase converting oxidosqualene into beta-amyrin, generating five rings and eight asymmetric centers in a single transformation.
Interaction partners:
Sequence:
MWKLKIAEGDKNDPYLYSTNNFVGRQTWEFDPDYVGSPGELEEVEEARRQFGENRYKVKPCGDLLWRLQFLREKNFKQTIPQVKVGDDEAVTYEAATTTLRRAVHFFSALQASDGHWPAEIAGPLYFLPPLVMCLYITGHLDTVFPAEHRKEILRYIYCHQNEDGGWGFHIEGHSTMFCTTLSYICMRILGEGPDGGVNNACARGRKWILDHGSATAVPSWGKTWLSILGVYEWMGSNPMPPEFWILPSFLPMHPAKMWCYCRMVYMPMSYLYGKRFVGPITPLILQLREELYAQPYNEIKWGKVRHVCAKEDIYYPHPLIQDLLWDSLYVLTEPLLTRWPFNKLREKALQTTMKHVHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKKHLARIPDYIWVGEDGMKMQSFGSQEWDTGFGIQALLASDLTHELGPTLMKGHDFIKKSQVKDNPSGDFKSMYRHISKGSWTFSDQDHGWQVSDCTAEGLKCCLIFSTMPEEIVGKKMEPELLYNSVNILLSLQSKNGGLAAWEPVTAQDWLELLNPTEFFADIVIEHEYVECTASAIQALVLFKKLYPGHRKKEIDNFITNAIRFLEDVQMPDGSWYGNWGVCFTYGSWFALGGLAAAGKTYDNCAAVRKAVNFLLESQLDDGGWGESYLSCPKKVYVPLEGNRSNLVHTGWALMGLIHSGQAERDPTPLHRAAKLLINSQMEDGDFPQQEITGVFMKNCMLHYATYRNIYPLWALAEYRRRVPLPSLGA
Protein: Mitochondrial 2-oxodicarboxylate carrier (ODC) (Mitochondrial 2-oxoadipate carrier) (Solute carrier family 25 member 21) (Q9BQT8)
Organism: Homo sapiens (Human)
Function: Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable).
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein.
Interaction partners:
- Deoxyribonuclease-1-like 2
- T-box transcription factor TBX20
- Mirror-image polydactyly gene 1 protein
Sequence:
MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW
Protein: Homeobox protein Nkx-2.3 (Homeobox protein NK-2 homolog 3) (Homeobox protein NK-2 homolog C) (Nkx2-C) (P97334)
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator essential for normal development and functions of the small intestine and spleen. Activates directly MADCAM1 expression. Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. May have a role during pharyngeal organogenesis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MMLPSPVTSTPFSVKDILNLEQQRHFHGAHLQAELEQHFHSAPCMLATAEGTQFSDAGEEDEEEEGEKLSYLNSLAAAEGHGDSGLCPQSYVHTVLRDACSGPKEQEEEVVSERSQKSCQLKKSLEAAGDCKTSEDGERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGTHAPPPPPRRVAVPVLVRDGKPCVTPSAQTYGSPYGVGAGAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSGSYGCAYPTGGGGGGGGTASAATTAMQPACSATGGGSFVNVSNLGGFGSGGGAQPLHQGAAAGSACTQGTLQGIRAW
Protein: Cysteine proteinase 1, mitochondrial (EC 3.4.22.40) (Bleomycin hydrolase) (BLM hydrolase) (Homocysteine-thiolactonase) (HTLase) (Hcy-thiolactonase) (Leucine aminopeptidase 3) (Y3) (Q01532)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.
Subcellular location: [Isoform Cytoplasmic]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion.
Interaction partners:
- Aminopeptidase 2, mitochondrial
- Galactose/lactose metabolism regulatory protein GAL80
Sequence:
MLPTSVSRSLYLKTFRSHLLRAPQIVLKRMSSSIDISKINSWNKEFQSDLTHQLATTVLKNYNADDALLNKTRLQKQDNRVFNTVVSTDSTPVTNQKSSGRCWLFAATNQLRLNVLSELNLKEFELSQAYLFFYDKLEKANYFLDQIVSSADQDIDSRLVQYLLAAPTEDGGQYSMFLNLVKKYGLIPKDLYGDLPYSTTASRKWNSLLTTKLREFAETLRTALKERSADDSIIVTLREQMQREIFRLMSLFMDIPPVQPNEQFTWEYVDKDKKIHTIKSTPLEFASKYAKLDPSTPVSLINDPRHPYGKLIKIDRLGNVLGGDAVIYLNVDNETLSKLVVKRLQNNKAVFFGSHTPKFMDKKTGVMDIELWNYPAIGYNLPQQKASRIRYHESLMTHAMLITGCHVDETSKLPLRYRVENSWGKDSGKDGLYVMTQKYFEEYCFQIVVDINELPKELASKFTSGKEEPIVLPIWDPMGALAK
Protein: 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) (G5ED98)
Organism: Caenorhabditis elegans
Interaction partners:
- SAC domain-containing protein
- Protein VAC14 homolog
- Phosphatidylinositol 4-kinase beta
- 1-phosphatidylinositol 4-kinase
- Phosphatidylinositol 3-kinase piki-1
- Phosphatidylinositol-3-phosphatase SAC1
- 1-phosphatidylinositol-5-phosphate 4-kinase
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
- Inositol polyphosphate-related phosphatase domain-containing protein
- PIPK domain-containing protein
Sequence:
MGDASELQFFEKLEPPPETEEPTPVSGGYFSNIIGQIFRSDGSPQPNGVVPPTEERQNLERTESGESRTSEESGFQRSLTDKFTGLLKSKVNPQLKDYNDSNFKQYWMPDSTGRECYQCEERFTTFRRRHHCRLCGQIFCAKCCSSHIDGAALGYMGELRLCDYCARKVQRLAEEGKQTPTTSTTRSQTPVNSRKISFDRNTAHKNSDTVRTVSNGAIWSLCPPESSMPPEITSPPQLGSRRNSLAQSSNGPGVPTILSVADLCASNSAMLTNSHSHPMITEEEESGPDWFRTMHPGMDGVINNETSDSADVFAYANLAGAITNEFTEMMDARAAEPTSATTDRKITFPSLSLDESVMNAAKEEQRDNLEELFRRNTERILDEVMKREYIREDKWRDLILKSVYEVVENVTVNVPSGDTMNIADYVHVKKVHKKEGKVDSEIIWGVACSRSLVYKSLSEEDESSHTTESIMIVSGSIEYERVSNKLSSIEPIIVQEEKFLEKQIDRIATKRASLILVEGGVSHIAAQLLHKRGIKVAVNVKMSILQRISRATGADIVSNSDSQLVEQNLGCCPEFQQRNMQQEDGRIKTLMIFADCQKETGCTVLLHGDDLKELVAVKRVVQFLVTIVYSNYLEQSYLNAFNTTIARRQSDCVVCEKRRAIVYSQGEKTEFEKNLYATMLSSSPVIEFEPPLLETATGRECPLIAYFKQPLYKLLKPGDVELIKQGYEEDIVPIPKKEPLLVDRRHAFAQCNRGAILDNVARSFRLFGGINFRRRTAQIVKHRKIVETEKQPFRAKDVLDPRVHQTLAVLFGSFSRKSPNAPYFCVRPWVVSMQYYKDHDMTIGEFLVKFCFNRSYECPSSNCEVPMLDHSRKLVYGKVCVEISTQTVNEAENAIESEQQKSIMTWRNCGKCNCSSQMVKFDKAIWHLSFAKFLEYIGNSCFTTDTIYPITNQNQCSHCFFHEKLYFFAMDNLVTTFKVIAIRPYSVVFSPIICSVKVLKVSRKELSDDVSRIATLALTACEDTNKQLAELDEEVQITPIVVKLAGAIRNTMALASESRMFAKNILSGDEDLIRSNDRLYREVTGTFMKVREVTYNLIALWNENCAAIKYPKRTPEDIQEIATLQKLENPFPSHLHLAIKLQPRLGVVVRDIQDTRGNFKPDIGSIIAYALSAVDYNKIPEAADTVSMDSASSSLKFSQMDDGENLASSQHLEVEFEDESASYYVKMLYAEKFRKLRELLIAEGEETFIRSLSNSTFWTPQGGKSGSFFYRTQDDRFVVKQMSRFEIQSFVKFAPNYFDYLTTSATESKLTTLCKVYGVFRIGYKSKTTTLKVDILVMEYLFYNHNVSQVWDLKGSLRNRLASTGKSANEMVLLDENFVKDLWNQQLYVLPHSKAAMNQAISNDSHFLSSQYIMDYSLLVGVDDDNGELILGIVDYMRTYTLDKKLESWVKIVAIPGAHLPTILSPEMYCARFSEAIDSYFPVVPDQWTGLGSIRSY
Protein: Efficient mitochondria targeting-associated protein 19 (Q12155)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:26928762, ECO:0000269|PubMed:30213914, ECO:0000269|PubMed:33596095}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to perinuclear ER membranes. {ECO:0000269|PubMed:33596095}.
Interaction partners:
- Uncharacterized membrane protein YMR253C
Sequence:
MKLGHREQQFYLWYFIVHIPITIFIDSSVVIPAKWQLGIAQKVVSDHIAKQHDFLLSEKPEWLYWFVVLELVLQLPLFVYFVNKFWNSSELQVNTNSRLKKWLRIYGWNASLTTLICIVVIFKRGYIPYDVLKTSLSMTQKCQLASVYLPTFLIPLRLCFV
Protein: Ephrin A3 (A0A8I5ZVQ1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGPGGGAEQYVLYMVNLSGYRTCNASQGSKRWECNRQHASHSPIKFSEKFQRYSAFSLGYEFHAGQEYYYISTPTHNLHWKCLRMKVFVCCASKDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTLLAS
Protein: Meiosis-specific nuclear structural protein 1 (Q8NEH6)
Organism: Homo sapiens (Human)
Function: May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q61884}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:30148830, ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:30148830}. Note=Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. {ECO:0000250|UniProtKB:Q2KIQ2}.
Interaction partners:
- Cilia- and flagella-associated protein 53
- Piercer of microtubule wall 1 protein
- Cilia- and flagella-associated protein 161
- RIB43A-like with coiled-coils protein 2
- Tektin-1
- EF-hand domain-containing family member C2
- EF-hand domain-containing protein 1
- EF-hand domain-containing family member B
- Ciliary microtubule inner protein 2B
- Parkin coregulated gene protein
Sequence:
MGSKRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKVYQQRSEICEEK
Protein: Ly49 stimulatory receptor 3 variant (Q5MKL6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSKQDVPCSTVRFKKSSGLQYQVRPEETQRPREAGWRGNNSCHQKMNSPNVPWQLTVIATGILLSLRLVAVAMLVTNIFQYSNENHELQKTHKRQHNSSTMEKDIKLKEEMLRNMSVESVHYNAFLDLINREQNRWYKKTKTVLASPQHTGGCDEMHWFCYGIKCYYFTMDIRIWRECKQTCQNYSLSFLKIDDKDELKFLQDHIIRDNYWIGSSYNNKKKEWAWIDNSPFDLDFVARTLLRKTGYCLYFSMSGLHDDDCGKRYLCICEKGMDKFPAPLCSVKETSHSAV
Protein: Histone deacetylase complex subunit SAP25 (25 kDa Sin3-associated polypeptide) (Sin3 corepressor complex subunit SAP25) (mSin3A-binding protein) (Q1EHW4)
Organism: Mus musculus (Mouse)
Function: Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:16449650}. Cytoplasm {ECO:0000269|PubMed:16449650}. Note=Shuttles between the nucleus and the cytoplasm.
Interaction partners:
Sequence:
MSPLPLRDPSHQANAGPRLVEPSCGPGVSLSNRTLCHPSWPMYDNWGRSPTTSERPEEEQVVSKDTGVPVRNYEDVFLLDPLLPCGQRVPLILTKPPQQAMDSRKLLLPPPIMSPSVHPSSSQACSSTWLSEAEMIALAGLLQMSQGEQTPNCVASSLPSTSCPDPVSVSEDPGPSGDQSCSGTDT
Protein: Coatomer subunit alpha (Q5F354)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR003354}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR003354}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR003354}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004347}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004347}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004347}.
Interaction partners:
Sequence:
MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLYYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSILIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHAIMICNRKLESLCNIHENIRVKSSAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDRLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVAERVRILRNCGQKSLAYLTAATHGLDEEAENLKETFDPEKETIPDIDPNAKLLQPPAPVMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDNVGTEGWGEDAELQLDEDGFVDAGEGFGEEGLGKGQEEGGGWEVEEDLDLPPELDVPAGPAGGAEDGFFVPPTKGTSPAQVWCNNSQLPVDHILAGSFETAMRLLHDQVGVTNFGPYKQLFLQTYARGRTTYQALPCLPTMYGYPHRNWKEAGLKNALPAVGLKLNDLIQRLQLCYQLTTAGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLIAICREYIVGLSMEIERKKLPKETLEHQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPTDTYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYCPEFQGQICRVTTVTEIGKDVIGLRISPLQFR
Protein: Uncharacterized protein YKL044W (P36092)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGYVIMTFSSARMSERRARIIYIWMHLSAYKINFPFVQFPTFFSLFRLQKKAAILIKNPSPFFLFFLFPYRKNSTARTIHQINQAVALVLLCVSHHLTYLPSVPSL
Protein: Probable ribose-5-phosphate isomerase 2 (EC 5.3.1.6) (Phosphoriboisomerase 2) (Q9ZU38)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19744161}.
Interaction partners:
- Ribulose-5-phosphate-3-epimerase, chloroplastic
- Ribulose-phosphate 3-epimerase
- Ribulose-phosphate 3-epimerase
- 6-phosphogluconate dehydrogenase, decarboxylating 2
- Transketolase-2, chloroplastic
- Transketolase-1, chloroplastic
- 6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic
- 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic
- Phosphoribulokinase, chloroplastic
- Ribose-phosphate pyrophosphokinase 1, chloroplastic
Sequence:
MALAYDPLFITSDKSLSAFDVASSPPQPMNLTQDELKRIAAYKAVEFVESGMVLGLGTGSTAKHAVDRIGELLRQGKLENIVGIPTSKKTQEQALSLGIPLSDLDAHPVIDLSIDGADEVDPFLNLVKGRGGSLLREKMIEGASKKFVVIVDDSKMVKHIGGSKLALPVEIVPFCWKFTAEKLRSLLEGYGCEANLRLGEKGKAFVTDNGNYIVDMHVEEDMGDLGAVSDAILRLPGVVEHGMFLDMASTVIIAGELGVKIKNKH
Protein: T-box transcription factor T (Brachyury protein) (Protein T) (J3KP65)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00201}.
Interaction partners:
Sequence:
MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEEPGDSQQPGYSQSGGWLLPGTSTLCPPANPHPQFGGALSLPSTHSCDRYPTLRSHRSSPYPSPYAHRNNSPTYSDNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSSSQYPSLWSVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLTHPVSAPSSSGSPLYEGAAAATDIVDSQYDAAAQGRLIASWTPVSPPSM
Protein: Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase) (Q96VN5)
Organism: Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Phosphoglycerate kinase
- Fructose-bisphosphate aldolase
- Fructose-bisphosphate aldolase 1
- Glucose-6-phosphate isomerase
- Dihydroxyacetone kinase
- Transaldolase
- 3-hydroxyisobutyrate dehydrogenase
- Enolase
- Transketolase
Sequence:
MPRKFFVGGNFKMNGTAKSITHIITNLNSAKLDPSTEIVIAPPAIYLVLARQLANGQVAVSAQNVFDKPNGAFTGELSVEQLRDEKITWTLAGHSERRVLLREDDEFVARKTKAAINGGLNVILCIGESLEEREAGKTIDVVTRQLDAVAEEVSPAEWNKVVIAYEPIWAIGTGKVATTEQAQEVHASIRKWLNEKISPEAAENIRVIYGGSVTENNCRDLAAQPDVDGFLVGGASLKPAFVDIINARL
Protein: Autophagy related 16 like 2 (H0YFG0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XRKGPAPAGRSRASPVSGREGGSSRPLEEGTGSSPACVRGAAPGSQDAFYPTRAKQARVSQELKKAAKRTVSISEGPDTLGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKRRGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQ
Protein: Polyadenylate-binding protein-interacting protein 5 (PABP-interacting protein 5) (Poly(A)-binding protein-interacting protein 5) (PAM2-containing protein CID5) (Protein CTC-INTERACTING DOMAIN 5) (Protein INCREASED POLYPLOIDY LEVEL IN DARKNESS 1) (Q9LYE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes polyploidy in dark-grown seedlings. Regulates the endocycle leading to hypocotyl elongation.
Interaction partners:
- Polyadenylate-binding protein-interacting protein 7
- Polyadenylate-binding protein-interacting protein 11
- Polyadenylate-binding protein-interacting protein 4
- Polyadenylate-binding protein-interacting protein 8
- Polyadenylate-binding protein-interacting protein 3
- Polyadenylate-binding protein-interacting protein 2
- Polyadenylate-binding protein-interacting protein 13
- Polyadenylate-binding protein-interacting protein 10
- Polyadenylate-binding protein-interacting protein 12
- Polyadenylate-binding protein-interacting protein 9
Sequence:
MKPGAFALNPHAASYVPISKRVDYGGGDDGLVFAAKSPTVEVSMPKKSSEMAYKQIRDDDLDLEMDIDMDIEYLLVTFSGLSQESITDVYLANGGDLEATIEMLNQLEIYSTESEENLPETLDIGDISESGPSTSKSTEVAASTSSVIPNAPVSA
Protein: L-lysine 3-hydroxylase (EC 1.14.11.-) (Alpha-ketoglutarate-dependent dioxygenase) (KDO1) (L-lysine hydroxylase) (C7QJ42)
Organism: Catenulispora acidiphila (strain DSM 44928 / JCM 14897 / NBRC 102108 / NRRL B-24433 / ID139908)
Function: Alpha-ketoglutarate-dependent dioxygenase that in vitro catalyzes the regio- and stereoselective hydroxylation of L-lysine, leading to (3S)-3-hydroxy-L-lysine. Can also use (5R)-5-hydroxy-L-lysine as substrate, but neither D-lysine nor L-ornithine.
Interaction partners:
- Putative metal-dependent hydrolase
Sequence:
MKNLSAYEVYESPKTSGESRTEAVSEAAFESDPEVSAILVLTSSEASTLERVADLVTAHALYAAHDFCAQAQLAAAELPSRVVARLQEFAWGDMNEGHLLIKGLPQVRSLPPTPTSNVHAVAATTPMSRYQALINECVGRMIAYEAEGHGHTFQDMVPSAMSAHSQTSLGSAVELELHTEQAFSPLRPDFVSLACLRGDPRALTYLFSARQLVATLTTQEIAMLREPMWTTTVDESFLAEGRTFLLGFERGPIPILSGADDDPFIVFDQDLMRGISAPAQELQQTVIRAYYAERVSHCLAPGEMLLIDNRRAVHGRSIFAPRFDGADRFLSRSFIVADGSRSRHARSSFGRVVSARFS