wanglab/gogpt-training-data huggingface dataset:
Protein: Polycystin-1-like protein 3 (Polycystin-1L3) (PC1-like 3 protein) (Polycystic kidney disease protein 1-like 3) (Q2EG98)
Organism: Mus musculus (Mouse)
Function: Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16891422, ECO:0000269|PubMed:18535624, ECO:0000269|PubMed:20538909, ECO:0000269|PubMed:21185261}; Multi-pass membrane protein {ECO:0000269|PubMed:34381056}. Note=Interaction with PKD2L1 is required for localization to the cell membrane. {ECO:0000269|PubMed:16891422, ECO:0000269|PubMed:20538909, ECO:0000269|PubMed:21185261}.
Interaction partners:
- Polycystin-2-like protein 1
- Transient receptor potential cation channel subfamily M member 5
Sequence:
MLLQRRSWLWLYIRIGVILGDILGRKPSIREQHGGNSCYQLNRLFCDFQEADNYCHAQRGRLAHTWNPKLRGFLKSFLNEETVWWVRGNLTLPGSHPGINQTGGDDVLRNQKPGECPSVVTHSNAVFSRWNLCIEKHHFICQAAAFPPQGASIWRNEFGPGPLLPMKRRGAETERHMIPGNGPPLAMCHQPAPPELFETLCFPIDPASSAPPKATHRMTITSLTGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQEDSPLGVISTHPQMSFQSSTSQALDETAGERVPTIPDFQAHSEFQKACAILQRLRDFLPTSPTSAQVSVANLLIDLSEQLLVLPFQKNNSWSSQTPAVSCPFQPLGRLTTTEKSSHQMAQQDMEQVEDMLETSLMALGEIHRAFCQQSLCPQSAVTLASPSATLMLSSQNVSTLPLSTYTLGEPAPLTLGFPSAEALKELLNKHPGVNLQVTGLAFNPFKTLDDKNIVGSIGNVQLSSAYQSIRVHDLIEDIEIMLWRNASMETQPTSLNTSTDHFTISVNITSLEKTLIVTIEPESPLLMTLHLGFQDQLAHTHFYLNISLPRDQVWQKDEEYTWVLTPENLWYGTGTYYIMAVENKSTEAAQHTPVLVSVVTAVTQCYFWDRYNRTWKSDGCQVGPKSTILKTQCLCDHLTFFSSDFFIVPRTVDVENTIKLLLHVTNNPVGVSLLSSLLGFYILLAMWASRKDREDMQKVKVTVLADNDPSSASHYLIQVYTGYRRRAATTAKVVITLYGSEGHSEPHHLCDPEKTVFERGALDVFLLSTGSWLGDLHGLRLWHDNSGDSPSWYVSQVIVSDMTTRKKWHFQCNCWLAVDLGNCERDRVFTPASRSELSSFRHLFSSTIVEKFTQDYLWLSVATRHPWNQFTRVQRLSCCMALLLCDMVINIMFWKMGGTTAKRGTEQLGPLAVTLSELLVSIQTSIILFPIHLIFGRLFQLIHPPEALPQLPFIQAAWPPALVCESPSLTQVVKELKETVGFLLRRNTQLLSECEPSSCSSCDINKLAKLLSGLIYCHLEDEGCHQQTESHWEDAVSENHYHFCRYLLQLLRRLKAHLEALGATQDHQSCDFSEAVSQLQNLQELLETQTLRRGPGPCRHSTSFPILSPGEGKKPMSFCLFRWLKCSCWLLLGVISLASAFFITLYSLELDKDQATSWVISMMLSVLQDIFISQPIKVIFLTLLFSLMANHMPWLNKDKEQHARRIVALWAKCPWSAPGLRDKNNPIYTAPAMNNLAKPTRKAWKKQLSKLTGGTLVQILFLTLLMTTVYSAKDSSRFFLHRAIWKRFSHRFSEIKTVEDFYPWANGTLLPNLYGDYRGFITDGNSFLLGNVLIRQTRIPNDIFFPGSLHKQMKSPPQHQEDRENYGAGWVPPDTNITKVDSIWHYQNQESLGGYPIQGELATYSGGGYVVRLGRNHSAATRVLQHLEQRRWLDHCTKALFVEFTVFNANVNLLCAVTLILESSGVGTFLTSLQLDSLTSLQSSERGFAWIVSQVVYYLLVCYYAFIQGCRLKRQRLAFFTRKRNLLDTSIVLISFSILGLSMQSLSLLHKKMQQYHCDRDRFISFYEALRVNSAVTHLRGFLLLFATVRVWDLLRHHAQLQVINKTLSKAWDEVLGFILIIVVLLSSYAMTFNLLFGWSISDYQSFFRSIVTVVGLLMGTSKHKEVIALYPILGSLLVLSSIILMGLVIINLFVSAILIAFGKERKACEKEATLTDMLLQKLSSLLGIRLHQNPSEEHADNTGY
Protein: Type I cytokeratin (Q9PWD8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Zgc:158846
Sequence:
MMSSSSIRMSSGGSSRLSVGGGASRVSGVRAGSVYGGAGGSGVRISSSSASRSYSAGGGAGFGGGAGAGFNLSDAIDVPTNEKATMQNLNDRLASYLEKVRSLEKANADLELKIRQFLDSKATPNARDYSAYYATISDLQAKILHATGVNGGIYLSIDNAKLAADDFRVKYENELSMRQSVEADIVGLRKVLDELTMTRSDLELQIEGLKEELIFLKKNHEEELLAARTQMSGQVNVEVDAAPQEDLTKILADIREHYEAVSAKNRKDLESWFQAKSESLNKEVAVSTETLQTSRSEITEVKRTLQSLEIELQSQLSMKASLEGTLADTQARYTNMLNGYQFQVSSLEEQLIQLRADLERQGQEYQMLLDIKTRLEMEIAEYRRLLDGEATTVSTSSSTTRKVVTIVEEVVDGKVVSSSSKATTETKTT
Protein: AT27361p (Uncharacterized protein, isoform H) (Uncharacterized protein, isoform I) (A0A1Z1CH25)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSQEINRSAQVVPAWLTRDYVEQKLRSYFRNDSLRLVNLDIKLALGNGENYSSVITRIYVEYTTDKSKDKQSTRFLVKESFADAGPAAQVLLSYGVYNRELDLYERILPQMAEVVRNELADSRKLFAGTVYVDRKRDSIIFEDMSLENYRVADRLKKLDLEHTHLVLEKLANFHAAGAALAERQPGIFAKNFDRGFFNQHTRGYEPIMKNLLMALSRSLELEPDLCQRYQAKIDRLVENVMEYGERSTTIVPGDFLTLAHGDLWTTNIMFQYDDKGHPINAIFIDFQFSAWNSPAIDLHYFFSTALQADIRLKKQPELVQFYYYKLNAALKKVQYSGNVPSLFVFHQQFRNRSFYAAFASLIFEPTMTYTGKEEASMDQIISLSEKGMRFKDDAFQAEETRKKMRLTLPFLDHLGLLDVM
Protein: Beta-Ala-His dipeptidase (EC 3.4.13.20) (CNDP dipeptidase 1) (Carnosine dipeptidase 1) (Q8BUG2)
Organism: Mus musculus (Mouse)
Function: Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q96KN2}.
Interaction partners:
- Carnosine synthase 1
- Cytosolic non-specific dipeptidase
- 4-aminobutyrate aminotransferase, mitochondrial
- Histidine ammonia-lyase
- Histidine decarboxylase
- Aldehyde dehydrogenase X, mitochondrial
- Glutamate decarboxylase 1
- Acidic amino acid decarboxylase GADL1
- Aldehyde dehydrogenase family 3 member A2
- Beta-ureidopropionase
Sequence:
MFSSAHSGLLEKLFHYIDLHQDEFVQTLKEWVAIESDSVQPVPRLRQKLFQMMALAADKLRNLGAGVESIDLGSQQMPDGQSLPIPPILLAELGSDPEKPTVCFYGHLDVQPAQKDDGWLTDPYTLTEVDGKLYGRGATDNKGPVLAWINAVSTFRALQQDLPVNIKFILEGMEEAGSIALEELVMREKDHFFSSVDYIVISDNLWLSQRKPALTYGTRGNCYFTVEVKCRDQDFHSGTFGGILNEPMADLVALLGSLVDSSGHILIPGIYDQMAPITEGEKTMYKNIDMDLEEYQNINQVEKFLFDTKEELLMHLWRYPSLSIHGIEGAFDEPGTKTVIPGRVLGKFSIRLVPTMSPSVVEKQVTQHLEAVFSKRNSFNKMAVSMVLGLHPWTANVNDTQYLAAQRTIKTVFGVNPDMIRDGSTIPIAKIFQAITQKSVMMLPLGAVDDGEHSQNEKINRWNYIQGSKLFAAFFLELSKQHSGHQMPSSVY
Protein: Aurora kinase (EC 2.7.11.1) (Spindle assembly checkpoint kinase) (Q59S66)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Associates with the mitotic spindle and on elongated and disassembling spindles. Also associated with the kinetochore (By similarity). {ECO:0000250}.
Interaction partners:
- Protein bir1
- Nucleoporin
- Nucleoporin NSP1
- Serine/threonine-protein kinase
- Probable kinetochore protein NDC80
- Inner centromere protein ARK-binding domain-containing protein
- Histone H3-like centromeric protein CSE4
- Kinesin-like protein
- Bub3p
- Probable kinetochore protein NUF2
Sequence:
MMLPRNSPHRTESTLAYNNNNSNNNNNNNGSSLFQRKPLAPINSEFKISKPQHIKPTTHSHTFTTPTPKTRNTATTTTNNNNRNNHQYRNPNLNTSLVFTPTKNSSSSSSSHSSSLLSSSPFVEEPENQPESNHTRATSHYRTTSTSQYKSSANKDASHSLITSSKRKTSTKQTSESTNPKRRTTTTATQNTNNNKILNPSLSSSTIRFSTVSSSTSSSTTSSSSSSHTSPKPQQQLTLDDFEFGKILGKGKLGRVYCVKHKQSGLIFALKVMSKSEIMNLKLEKSLRREIEIQSNLYHINITRLYSWFHDSINIYLLLEYSIEGELYTHLKKLKRFDNIMASNYIFQITQALIFLHQRGIIHRDLKPENIMVSLDNQLKLSDFGWSVQINQNQNQNQIHNQTQTQKTPHQKKQKQKRLTICGTLDYLPPEMIESKSHDFSVDIWALGILCYELLVGKPPFEAINRNITYEKIAKVDIKYPSNLDVDAIDLISKLVVKDPNKRLSLKEVLNHNWIIKNKPKWPKNIYK
Protein: histone deacetylase (EC 3.5.1.98) (B1WBY8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
ALRSRALPAPARRPAPGCPCCEGRRARRLPQPSCLAAGPRRARAAGGGAAARRRRPEPMAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAVLELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKEAEDKRTDVKEEDKSKDNSGEKTDTKGAKSEQLNNP
Protein: NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 5) (NADH-plastoquinone oxidoreductase subunit 5) (P0C326)
Organism: Oryza sativa (Rice)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MEHTYQYAWVIPLLPLPVIMSMGFGLFLVPTATKNLRRIWAFPSVLLLSIAMVFSVHLSIQQINGSSIYQYLWSWTVNNDFSLEFGYLIDPLTSIMLILITTVGILVLIYSDDYMSHDEGYLRFFVYISFFNTSMLGLVTSSNLIQIYFFWELVGMCSYLLIGFWFTRPIAASACQKAFVTNRVGDFGLLLGILGFFWITGSLEFRDLFKIANNWIPNNEINSLLTILCAFLLFLGAVAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGIFLIARLLPLFISLPLIMSFISLIGTLTLFLGATLALAQRDIKRSLAYSTMSQLGYMMLALGIGSYQAALFHLITHAYSKALLFLGSGSVIHSMEPLVGYSPDKSQNMVLMGGLRKYIPITRTCFLWGTLSLCGIPPLACFWSKDEILSNSWLYSPFFGIIASFTAGLTAFYMFRIYLLTFDGYLRVHFQNYSSTKEDSLYSISLWGKRISKGVNRDFVLSTAKSGVSFFSQNLSKIHVNTGNRIGSFSTSLGTKNTFVYPHEPGNTMLFPLLILLLCTLFIGSIGIHFDNEIGELTILSKWLTPSINFFQESSNSSINSYEFITNAISSVSLAIFGLFIAYMFYGSAYSFFQNLDLINSFVKGGPKKYFFHQLKKKIYSWSYNRGYIDIFYTRTFTLGIRGLTELTQFFDKGVIDGITNGVGLASFCIGEEIKYVGGGRISSYLFFFLCYVSVFLFFFLS
Protein: D-arabinitol dehydrogenase 1 (EC 1.1.1.287) (NADP-dependent D-arabitol dehydrogenase) (Q4R0J7)
Organism: Uromyces fabae (Rust fungus)
Function: D-arabinitol dehydrogenase which mostly produces D-arabinitol in haustoria, the appendages of the parasitic fungus that penetrate the host's tissue and draws nutrients from it. D-arabinitol accumulation may serve as a carbohydrate storage compound. D-arabinitol is also capable of quenching reactive oxygen species involved in host plant defense reactions, thus providing protection for the rust fungus during the pathogenic interaction.
Subcellular location: Cell projection. Note=Localizes in the lumen of haustoria.
Interaction partners:
Sequence:
MATQTLPAQMTALYYEKPRDFSIIKADVPLIDHDEVLLKVSMCGVCGTDQHIHEGEFIAKFPLIPGHEVIGTIVLAGNQVENVKVGDRVVCDVSETCHKCFFCQRGTPLFCESFEAHGVTLNGGFAEYAKFRAAKVFPIKNLTDEQATLVEPASCAVHGLDKIRPKPGSECLLIGAGPTGLMLAQLLKLNGAQRVVLAANKGMKMDIARKINAADEYIDLDRKDAANQWAQLKEDNPHGFDVVVEATGVESIVNDSINYVRRGGTLLVYGVYDNAARVTWSPTKIFQDEINIVGSFAQIHCFPRAVAYLESGKIRTDGMVTHVYKIEEYQEALDKMASRQCLKIAVKPN
Protein: Translocase of inner mitochondrial membrane 44 (M0QXU7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAAALRSGWCRCPRSKSYSSGNRKGFLSGLLDNVKQELAKNKEMKESIKKFRDEARRLEESDVLQEARRKYKTIESETVRTSEVLRKKLGELTGTVKESLHEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGEKLGRTAAFRALSQGVESVKKEIDDSVLGQTGPYRRPQRLRKRTEFAGDKFKEEKVFEPNEEALGVVLHKDSKWYQQWKDFKENNVVFNRFFEMKMKYDESDNAFIRASRALTDKVTDLLGGLFSKTEMSEVLTEILR
Protein: Vacuolar protein sorting-associated protein 32 homolog 1 (AtVPS32-1) (Charged multivesicular body protein 4 homolog 1) (ESCRT-III complex subunit VPS32 homolog 1) (O82197)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity).
Subcellular location: Endosome {ECO:0000250}.
Interaction partners:
- Vacuolar-sorting protein BRO1
- Vacuolar protein sorting-associated protein 2 homolog 2
- Vacuolar protein sorting-associated protein 24 homolog 1
- Vacuolar protein sorting-associated protein 2 homolog 3
- Vacuolar protein sorting-associated protein 36
- Vacuolar protein sorting-associated protein 20 homolog 2
- Vacuolar protein sorting-associated protein 2 homolog 1
- SNF7 family protein
- Putative vacuolar protein sorting-associated protein 24 homolog 2
- ESCRT-related protein CHMP1B
Sequence:
MFMNRLFGKPKQETSTLQTLDKLNETLEMLEKKENVLLKKATGEVEKAKEFSRAKNKRAAIQCLKRKRLYEQQVEQLGNFQLRIHDQMIMLEGAKATTETVDALRTGASAMKAMQKATNIDDVDKTMDEINEQTENMKQIQEALSAPFGANDFDEDELEAELDELEGAELEEQLLQPVPIHVPQGNKPARAPAQKQPTAEEDELAALQAEMAL
Protein: Mitochondrial tRNA pseudouridine synthase A (E5KMT5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGLQLRALLGAFGRWTLRLGPRPSCSPRMAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAFAHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFHNFTSQKGPQDPSACRYILEMYCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVPKAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWAQEEGKVAAFKEEHIYPTIIGTERDERSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (D3ZDH4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Ephrin-A1
- Ephrin A2
- Ephrin-A4
- Ephrin-A5
- Ephrin-A3
- Ephrin-B1
- Ephexin-1
- Ephrin B2
- Ephrin-B3
- Tyrosine-protein kinase
Sequence:
MERRWPLGLALLLLLLCAPLPPGARAEEVTLMDTSTAQGELGWLLDPPETGWSEVQQMLNGTPLYMYQDCPIQEGGDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLFYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLASGSVKLNVEHCSLGHLTRRGLYLAFHNPGSCVALVSVRVFYQRCAETVHGLAHFPHTLPGPTGLVEVAGTCLSHAQISLGSSGTPRMHCSPDGEWLVPVGQCQCEPGYEESGGSVGCTACPTGFYRMDMNTLHCLKCPQHSVAESEGSTICTCENGHYRAPGEGPQVACTRPPSAPQNLSFSASGTQLSLRWEPPRDTGGRQDIRYSVECLQCRGIAQDGGPCQPCGKGVHFSPAASGLTASTVQVEGLEPYANYTFTIKSQNRVSGLDSSSPSSASLSINMGQAESLSGLSLKLVKKEPRQLELTWAGSRLQNPGGNLSYELHVLNQDEEWHQMVLEPRVLLTKLQPDTTYIVRVRTLTPLGPGPFSPDHEFRTSPPVSRSLTGGEIVAIIFGLLLGIALLIGIYVFRSRRGQRQRQQRQRERTTNVDREDKLWLKPYVDLQAYEDPAQGALDFAQELDPAWLIVDTVIGEGEFGEVYRGALRIPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLKEREDQLVPGQLVAMLLGIASGMNYLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHLEQLLTDPHSLRTIANFDPRVTLRLPSLSGSDGIPYRSVSEWLESIRMKRYILHFRSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSIQGFKD
Protein: Calpain-10 (EC 3.4.22.-) (Calcium-activated neutral proteinase 10) (CANP 10) (Q9HC96)
Organism: Homo sapiens (Human)
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.
Interaction partners:
- Aminopeptidase RNPEPL1
- G-protein coupled receptor 35
- Calpain small subunit 1
- Aminopeptidase B
- ATP-sensitive inward rectifier potassium channel 11
- Calpastatin
- Fibrillin-3
Sequence:
MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAIRAVAKNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEGPGPRCVRITLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSIMAVMKT
Protein: Dicarboxylic amino acid permease (P53388)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Can transport glutamate, aspartate, glutamine, asparagine, serine, alanine and glycine.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Arrestin-related trafficking adapter 3
- Vacuolar amino acid transporter 5
- Ammonium transporter MEP1
- Ammonium transporter MEP2
- Arrestin-related trafficking adapter 6
Sequence:
MKMPLKKMFTSTSPRNSSSLDSDHDAYYSKQNPDNFPVKEQEIYNIDLEENNVSSRSSTSTSPSARDDSFAVPDGKDENTRLRKDLKARHISMIAIGGSLGTGLLIGTGTALLTGGPVAMLIAYAFVGLLVFYTMACLGEMASYIPLDGFTSYASRYVDPALGFAIGYTYLFKYFILPPNQLTAAALVIQYWISRDRVNPGVWITIFLVVIVAINVVGVKFFGEFEFWLSSFKVMVMLGLILLLFIIMLGGGPNHDRLGFRYWRDPGAFKEYSTAITGGKGKFVSFVAVFVYSLFSYTGIELTGIVCSEAENPRKSVPKAIKLTVYRIIVFYLCTVFLLGMCVAYNDPRLLSTKGKSMSAAASPFVVAIQNSGIEVLPHIFNACVLVFVFSACNSDLYVSSRNLYALAIDGKAPKIFAKTSRWGVPYNALILSVLFCGLAYMNVSSGSAKIFNYFVNVVSMFGILSWITILIVYIYFDKACRAQGIDKSKFAYVAPGQRYGAYFALFFCILIALIKNFTVFLGHKFDYKTFITGYIGLPVYIISWAGYKLIYKTKVIKSTDVDLYTFKEIYDREEEEGRMKDQEKEERLKSNGKNMEWFYEKFLGNIF
Protein: Probable 2-methylcitrate dehydratase (2-MC dehydratase) (EC 4.2.1.79) ((2S,3S)-2-methylcitrate dehydratase) (Q12428)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the stereospecific dehydration of (2S,3S)-2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate.
Interaction partners:
- Citrate synthase 3, mitochondrial
- Acetyl-coenzyme A synthetase 1
- Mitochondrial 2-methylisocitrate lyase ICL2
Sequence:
MFLAKNLKNNKIKVCLPKKKFAALSTASIQTNERPNPDKVLKDIAKYVHETPLKSSLALDTARLCFLDTLGCGLAALKFKQAQNIIKPIVPGTIVPSGTKILGTSYVMDPVKGAFAIGTLIRWLDYNDCWLAAEWGHPSDNLGGILAVADHLSRLNKATHGKNGKQFLVKDVLEAMIKAHEIQGIIALENSFNKVGLDHVVLVKVATAGVVSKMLGLSQEQTIEALSQAFVDGQSLRTYRHAPNTGSRKSWAAGDAVSRAVNLAYLVKNANVGTIPSVLTARTWGFYDVLFKGKPFSFQQRSKYDSYVMENVLFKISFPAEFHAQTAVEAAVKAYRILAKQGKTFKDIKSIRIRTQEAAMRIIDKSGPLYNYADRDHCIQYMIAVPLITGNLTATDYSDEVARNPEIDNLRSKMYCIEDTHLTQNYHDPDKRSIGNALLIELNDGTQLDEIFVEYPVGHKFRREEGIPLLMNKFQRHLREHFVESPDKVDLIMKVSSKTNFLNMQIDKYMDLFTEG
Protein: Indole glucosinolate O-methyltransferase 1 (EC 2.1.1.-) (Q9LPU5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in indole glucosinolate biosynthesis. Catalyzes methoxylation reactions of the glucosinolate indole ring. Converts the hydroxy intermediates 4-hydroxy-indol-3-yl-methylglucosinolate (4OH-I3M) and 1-hydroxy-indol-3-yl-methylglucosinolate (1OH-I3M) to 4-methoxy-indol-3-yl-methylglucosinolate (4MO-I3M) and 1-methoxy-indol-3-yl-methylglucosinolate (1MO-I3M), respectively.
Interaction partners:
- Cytochrome P450 81F2
- Cytochrome P450 81F4
- Cytochrome P450 81F1
- Cytochrome P450 81F3
- Probable inactive 2-oxoglutarate-dependent dioxygenase AOP2
- Cytosolic sulfotransferase 16
- Transcription factor MYB51
- Transcription factor MYB122
- Probable 2-oxoacid dependent dioxygenase
- Transcription factor MYB34
Sequence:
MGYLFQETLSSNPKTPIVVDDDNELGLMAVRLANAAAFPMVLKAALELGVFDTLYAAASRTDSFLSPYEIASKLPTTPRNPEAPVLLDRMLRLLASYSMVKCGKALSGKGERVYRAEPICRFFLKDNIQDIGSLASQVIVNFDSVFLNTWAQLKDVVLEGGDAFGRAHGGMKLFDYMGTDERFSKLFNQTGFTIAVVKKALEVYEGFKGVKVLVDVGGGVGNTLGVVTSKYPNIKGINFDLTCALAQAPSYPGVEHVAGDMFVDVPTGDAMILKRILHDWTDEDCVKILKNCWKSLPENGKVVVIELVTPDEAENGDINANIAFDMDMLMFTQCSGGKERSRAEFEALAAASGFTHCKFVCQAYHCWIIEFCK
Protein: Eukaryotic release factor 3, putative (Q385F3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Eukaryotic peptide chain release factor subunit 1
- Regulator of nonsense transcripts 1, putative
- Ribonuclease L inhibitor, putative
- 40S ribosomal protein S23, putative
- Tyrosyl/methionyl-tRNA synthetase, putative
- Methyltransferase small domain-containing protein
- RNA-binding protein, putative
- RNA-binding protein, putative
- Polyadenylate-binding protein
- Polyadenylate-binding protein
Sequence:
MSGWAQPGGFNPNANAFTPSHPQGQYPQQHQGHAGGAPQQGYYYQSPYQQQQQAVYNPAFVSQQGGYNPSYQQQGGYVPGYNHQMGGYNQGYGGQQGGYTPVYNQQRGGYNAVHNQQRFQSQQYDRAGQGTGQGGAPTQGYVNPPQQVEPEEQPKTSSAQTSKLSLGGGASEFVPPAKKAKAGTLSLSKKKVEETKPKEGNAKSDSQPKDNAGNTTTTTADDKKGSAKLTPEELREQVRCEIAKQREQNKKEFVRDPRPHFNIVFCGHVDAGKSTISGHLLMEKGLVDQREMEKLRREAEVHHREGWEYAYVMDVSEDERTKGITRETGAAYVETEKRRITVLDAPGHKAFVPSMIGGATQADVCVLVISSRTGEFETGFEKGGQTREHAMLVRTCGVKQMICVINKMDEVNWSKERYDAILGKLKPFLRQNGYDEEKAKNLIFIPIAGLTGDNLIRETAEGVCPWYKGPTMMSFIDELVLPETKSENDVLCIPLVGSYKDEGRVFVYGKVESGSVAVGEKIQILPSKQEAVVEGISIEATEFEKCYPGDNVHLRVRGVDEGDVHAGYVGTSVPTSLRAVEYFQARVVILDVKNIICAGSRVMLHAHAAQEEVSFHKLLAKVDKKTGEVVQKDPTHVKAGDVVIARMELERALVLEPHKDFDKMGRFMLREDGKTIAIGLVMKLYESTRESLANAGKA
Protein: Lipase (Q2YKK5)
Organism: Brucella abortus (strain 2308)
Interaction partners:
- Phosphatidylglycerol lysyltransferase C-terminal domain-containing protein
Sequence:
MDAMLARNIIVMPVELGPWRAALDKEDGECNYLDSDFEAIAKEALRGLDLGVYFHPVLTGIGQGATIAYAAASDSPDATIAGAVSLDPTPARTRLPSCTEKAEAIKGPDGGFTYSVNAALPAPALLISPPGSPVNNPVEARRKNIAVLQTAPDFSARMKMAVDNVVAMADQDAKNEALPIIDLPAKGGNADMVAVFYSGDGGWRDIDKSIGEWLQAHGVHVIGVDSLRYFWSERTPEEIANDTTAMIKKADPTGKLPVAVLGYSFGADTFPFAWKYLDPSIQDRTRMVGLLGVETTTTFQVSIEGWLGMNGDKDVVPAIASIPLDRVVCVYGQEEDDTACTADELKGMDTMKLPGGHHFDENYEPIAAALLDKMRSRAGLPPRPAR
Protein: Amelogenin, Y isoform (Q99218)
Organism: Homo sapiens (Human)
Function: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Testis-specific Y-encoded protein 1
- Putative serine/threonine-protein kinase PRKY
- F-box-like/WD repeat-containing protein TBL1Y
- Protocadherin 11 Y-linked
- Protocadherin-11 X-linked
- Sex-determining region Y protein
- Zinc finger Y-chromosomal protein
- cAMP-dependent protein kinase catalytic subunit PRKX
- Enamelin
- Thymosin beta-4, Y-chromosomal
Sequence:
MGTWILFACLVGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRIALVLTPLKWYQSMIRPPYSSYGYEPMGGWLHHQIIPVVSQQHPLTHTLQSHHHIPVVPAQQPRVRQQALMPVPGQQSMTPTQHHQPNLPLPAQQPFQPQPVQPQPHQPMQPQPPVQPMQPLLPQPPLPPMFPLRPLPPILPDLHLEAWPATDKTKQEEVD
Protein: Asator, isoform H (EC 2.7.11.1) (L0MPN7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTSEDLLQPGHVVKERWKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDLKQFLEHIQSLTYGDRPDYAMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIPIKSDYMHGNITQMTVAASNASGTEYIRKRAEIETAHITATDPLNIKEKVDKNCNATSLAQPAKGSGEPMVQHGNAANNQNITSKGLQQQSTLTNSQVAIANIQSAPSMIEREDVQYTKLEEGAPTKFITMKPNGECDNVDIAAKCIFEQKHVEANDDIVGRASLSGVEQHYKSQIKKHNSPEIANKQIQRTGTVTNDKTSEVNRSTEEQKSTFGRLRVLTAPPMSVHDLPSGGGHSHQVSDLSGKQDPYAATSNAAPIGINSSSTKFGSQHGQIFGLAAMPPINRRSATSTNLRPSSSASQRINSGSTIGGAVGNGSNTARSSVAGDHSVTQFALIDDENVSALQQVTKGGALTLASQWKSQFDDSEDTTDNEWNREHQLQPNLEQLIKLDISLPLNEAKPFPQHGVAGTGKLINPPGEAKGRPKRYTLNITGIENYEALRISIPNCWSEPAMGNVLRKGLEPPAVQQAAFDDTVYRMDIARNVCVRETYSEITHLARPSTSSVLRNRLPSPFKKDSALQLNSTNDSLDKSRHRNSLPNVSVNDIFDDLQMKLNLDLGSAIQENNCCISGRLEIRVIPKDTSHPDDSVYYDAMGAVKNTPTANEGHDHSDQAVNNCDEMEATSAVIAFPNKSISKIMSPPGRDATEERTGASLCSLYSAGVNKLKLNGNTAPRTQFKKGSTDGFGENESEFDFPLLNPSKIPVRQSKCASWAGADFISASKPLESAEVPQEIPYHPQSDTTYSVIDSIPVRKTTYSIALECPPNISDLTPGLRRRRESTEGKYVTDPTQLPLKFQRPRSRTSSRTRGIPNAMLENSDDNGTVMSAEKTGHGHVVKTEGVKNFTTSENSSEVNPKCTISPPPGDPKIENSARLRRYRHNID
Protein: Transmembrane protein (Q57YL3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSWFGWDRKSGDEKAEREETEKTIAAIFSPSHATVRDAPDSKDSILRESTVRLFKKGEEPVPYTAVGGTFQTKHTVETMREDRMSGGEKPVPLDLLPPCPIAGYELRSDGLVDNIEKPPRTLTAQELRSLVAGLSSIEQRARYEVDTQLPQQVHNRGRRGLEVVVNPCLHMCGLYLMLWKAPRLYFNASPRGSAFFTRVMTLLRWNMPEIEKEKLARKHRRLLQATNARVTLAFLTGVFLTAVAVITRPPVDVLDVGPDVEVGKRSVGFQQHSEAALRWLWLVYYHHPAYKPLAQGTRPPILLESSSR