Protein: Polycystin-1-like protein 1 (Polycystin-1L1) (PC1-like 1 protein) (Polycystic kidney disease protein 1-like 1) (Protein rikishi) (Q8R526)
Organism: Mus musculus (Mouse)
Function: Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.
Subcellular location: Cell projection, cilium membrane {ECO:0000269|PubMed:21307093}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Polycystin-2-like protein 1
Sequence:
MDVDEDQHAVAVLHHKIQANPELCVSDEQDSCPSDAPKGTARDPESQKPSSPAPWDKNVLNTGSEERLSFINGEPQAPPNWDEGTNSFSNPPPGISHTCNLSASWYHPESSSPLTQHPPRATLVTQPENVEHFAICCFPETDAQALPALGIRVHVASGTALCLLLDFGDNCGAQMRLCTLAGATTVTGYHQYRKEGVYELKAVVHDFHRAEELGPYYVDISHGNVSVFMNSSSIHDSEALSFADSLPQQRGTVVVHCFSSISSYNVSFISQTQVASGQAWCGVTVGYKMQSVSVYTNGTVFAANTNITFVAITEETIPLEFAWYFGENPPVMTTSRSIRRRLSVPQWYRVKVKATSRIGSVVSEPHLIRVQKRIMANRLVSTASALVNANVSFECRLNFGTDVAYLWNFGDDTIELGSSSSSHVYSREGEFTVEVLAFNNVSSTTLRKQLFIVREPCQPPPVKNMGPAKVQIWRSQPLRLGVTFEAAILCNISQGLSYTWSFVSAEMTTVTLPTAVNTRRQTIMLPSYTLECGNYTAIAKVQIKGSMVYSNYCVGVEVRARAPVSVISEGTHIFISTATSTFIILRGAQSYDPDNPGAALRYHWTCTAASSPRWPCFDNSTSYQVDTQAPAISFPAKWLSECCDQFLVTLTVSSRGQNSSQALMFLSTRPDLAFRFVHISWVNFRDISVNWNEEVSLRAVCEDCGDVPDLTYSWDLFLVNATEKSAVEVPFCSTVGLLGALALGTSLKSSKSDLPSNLRAPLTPHSPEPSPTPLGWTALSNLGSISAESTAGGHHVPASGAVAGSGEPMEEYSSLSSLAEEALMTNSSEGSWPSPSSSTDFDDFEAYYSDIQEAVLSLGRQPGTSTNFQEAGPSLSAEESASYGDNLLGPFLHTGRAKPTLMIDWPKALVSQAAFHGYTTSGIMGPAVTIKPFSLSSGKTYVLQASVASKHVLLGKAQLYLTVNQAPQDMSCQVRPHHGMEAYTIFSVFCMSGKPDFHYEFRYRIGNTSSHTLYRGQDTQHYFLLPAGDSSDNYKVIVSTEITDGHGSKVQPCTVAVTVLPRYHGNDCCDKELYNSTLESLSTLRLAGSYMETRNYITMITGILSRLYVESRNTSSCGQWSQIQDVLISSACKVPYTDQEGMMDSIHILRDLISFPNKLSLTSAMCIFKYTKMFLAQGQFSRRLLVDKKLRVEFVLLISGVWEAAKEDARDGDYLQEEGMKIISDMLLACLSDEHQIHVSTGQMEFQTLLHRSPQSSIQNLGFVQVHFPSDLASLHSTTQEATQSSCYISQLMFFMKSPYLGGQVPGQVGGVMIPRLYSCESRRPILRGQLETPVTMEFGEEDYLHKRNPAMFVLLRDEVNVHRFTGLSENSQESLQIHIKFSKPVTRPFPIILLVRFSEKATPSDFLVKRVYFWDEQTVQMYVPAAPWKGANVGYLSLLDADYDRKPPNKYLAGAVNYTVHFQWIQCVFWDKTEWRSEGPYPQPGSSPEKVNCSYHHLAPVSVLRRKLNATLEVSSISEFQSHPHNLLPGIFSAFLLVLYGILVSKSRYVDCHEKKNPGFIFLEEDTLPGYQLYAVVIDTGFRSPVRFTSKVFIVLCGENGCSETKELCCPEKPLFGRNSRHTFILSIPNQLGPLQKIRLWHDSSGSSPCWFISHVMVKELCSGQAWFFSAQCWLAVSKLGGHVLREFFCLSHGLGFWKLFYSKFTEYLEDFHIWLSLYSQPPSRSYLHTQRLAVSFCLLCVYSCLTALVTVRDHQQRPLDVGPTAITLEPFCMALLCTLLACPVAQLLSLLFRCSKEARGDMQASTQWPLRGVKTETPQGHDSSGRPDSRQPSPHPTSDLLPWNDQAWRIAASSSAVVCSPFPMEACSHKHHDLREKSHYSPPSSQAPGSGFEELGSQKSRVCLLWSSSVAWAISGSASLACGLGTGFLGYWFVPAQCMWWLYLLLLSLVCCAFITQPLMICLAALVFAWKRKHDSKFFTESLQDATKGLDLELEEHSRTRVPLSPISYSPDTAEEAERVLATRQRERHLRWAQTPSKAKLRVTGERLRRESIMQAALRDMTTHSIMLLLLLFIAYGRFCPGEISLNHAIRKAFTRKANHSLGDLSSTEDWWDWTLSTLLDELYPERTSARAWGAQPGALGGQCHLIGPPVVKLLKISAGTACTPPRPFSELVEDVLPMHSNDLDLENQNVSPGGPETCGVKKESYMHSLGKTRHEAHAALTALRASKWIDHSTRAMSVHFTLYNPPTQLFTSVILGTECLPSGGLVPSFLVESFRIFYSDSALKYLLMLSELLFLVLNVIHLCFQLWGMTTKGILSYWRKPRHWLELSMVGVAIAYYAASGHLTTLAVNITDQFHKGLYQRLVDIGLMVSWHQRARCLQGILLFLWMLKYVHLLSSLSTMTPFSAVTCFPLFRVLLVGALLLAAHYHSRWFLLFTGTLSHGTSAEAFPGLLLQFPGRSKKDSWHNCLKSDHGVMRCYYGTLFLLLATLGFRMLRATFLTVFQNRKSSHRKPLVTLKDIAVYTWHKVLTLLGLETTLEETEVATDHIYYLDEFSSLLDELLMKIDGLSDSLELSILENQWKRALESRAGDSPPVGSSEYQATGVSGPLAAESE