wanglab/gogpt-training-data huggingface dataset:
Protein: Homeobox protein Hox-B5b (Homeobox protein Zf-54) (Hox-B5-like) (P09013)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-B7a
- Homeobox protein Hox-B6b
- Homeobox protein Hox-B6a
- Homeobox protein Hox-C4a
- Ligand-dependent nuclear receptor corepressor.
- Homeobox protein Hox-B4a
- Homeobox protein Meis3
- Homeobox protein Hox-B3a
- Short-chain dehydrogenase/reductase 3
Sequence:
MSSYFLNSFSGRYPNGSDYQLLNYGTNGAMNASYRDSTSMHSGSFGYNYNGIDLSVNRPNNGHFGAVGDNSRAFQNPSQETRYRQSSCSLSSPDPLSCATSDTLELKGSSPPSDQSTPTGNSRLTNSNNLTSSNSTHFADTDETNVSSETEEGAQTTTTSHTQKQESVATSTTTPNDGQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQN
Protein: Type IV inositol polyphosphate 5-phosphatase 6 (At5PTase6) (EC 3.1.3.36) (EC 3.1.3.86) (Protein COTYLEDON VASCULAR PATTERN 2) (Q9LR47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has phosphatase activity toward PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Required for the patterning of procambium and during the differentiation of vascular tissues. Acts before the acquisition of preprocambial identity. Seems to be also involved in the abscisic acid (ABA) signaling pathway. Acts redundantly with CVL1 for maintaining vascular continuity. Regulates phosphoinositide-dependent VAN3 localization.
Interaction partners:
- Phosphoinositide phosphatase SAC7
- Phosphoinositide phosphatase SAC6
- Phosphoinositide phosphatase SAC8
- CLAVATA3/ESR
- ADP-ribosylation factor GTPase-activating protein AGD3
- Membrane-associated kinase regulator 5
- Protein BREVIS RADIX
- CLAVATA3/ESR
- ADP-ribosylation factor GTPase-activating protein
- Phosphatidylinositol 4-phosphate 5-kinase 1
Sequence:
MREEKSKTNKLAWSKKMVRKWFNIKSKTEEFQADDPSSAGIEVEHRSSFSAEKAPSTIKNTKTEKLSKNWEQQARQRRMNYENPRIIDVQNYSIFVATWNVAGRSPPSDLNLDEWLHSSAPADIYVLGFQEIVPLNAGNVLGAEDNGPAQKWLSLIRKTLNNRPGTSGTSGYHTPSPIPVPMAELDADFSGSTRQKNSTFFHRRSFQTPSSTWNDPSIPQPGLDRRFSVCDRVFFSHRPSDFDPSFRGSSSSHRPSDYSRRPSDYSRRPSDYSRRPSDYSRRPSDSRPSDYSRPSDYYSRPSDYSRPSDFSRSSDDDNGLGDSPSTVLYSPGSAANENGYRIPWNSSQYCLVASKQMVGVFLTIWVKSELREHVKNMKVSCVGRGLMGYLGNKGSISISMLLHQTSFCFVCTHLTSGQKEGDELKRNSDVMEILKKTRFPRVKSSEEEKSPENILQHDRVIWLGDLNYRIALSYRSAKALVEMQNWRALLENDQLRIEQKRGHVFKGWNEGKIYFPPTYKYSRNSDRYSGDDLHPKEKRRTPAWCDRILWFGEGLHQLSYVRGESRFSDHRPVYGIFCAEVESAHNRIKRTTSYSASRVQAEELLPYSRGYTELSFF
Protein: Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6) (Q96HZ4)
Organism: Homo sapiens (Human)
Function: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transducin-like enhancer protein 1
- Achaete-scute homolog 1
- Musculin
Sequence:
MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
Protein: UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (rUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) (Q9JLA3)
Organism: Rattus norvegicus (Rat)
Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:11535823}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:11535823}.
Interaction partners:
- Selenoprotein F
- Calnexin
- Endoplasmin
- Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Neutral alpha-glucosidase AB
- Calreticulin
- Calreticulin
- Calreticulin
- Protein disulfide-isomerase A4
- Serine/threonine-protein kinase Chk1.
Sequence:
MCSRGDANAAGAAAARRVTGLCYNMGLLIALALLCLFSLAEANSKAITTSLTTKWFSAPLLLEASEFLAEDSQEKFWSFVEASQNIGSSDQHDTDRSYYDAILEAAFRFLSPLQQNLLKFCLSLRSYSASIQAFQQIAVDEPPPEGCKSFLSVHGKQTCDLGTLESLLLTAPDRPKPLLFKGDHRYPSSNPESPVVIFYSEIGHEEFSNIHHQLISKSNEGKINYVFRHYISNPRKEPVHLSGYGVELAIKSTEYKAKDDTQVKGTEVNTTVIGENDPIDEVQGFLFGKLRELYPSLEGQLKEFRKHLVESTNEMAPLKVWQLQDLSFQTAARILAAPVELALVVMKDISQNFPTKARAITKTAVSAQLRAEVEENQKYFKGTIGLQPGDSALFINGLHIDLDTQDIFSLFDTLRNEARVMEGLHRLGIEGLSLHNILKLNIQPSETDYAVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIVDPVHETTAELVSIAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVGQEVDGYHAFQTLTQIYNKVRTGEKVKVEHVVSVLEKKYPYVEVNSILGIDSAYDQNRKEARGYYEQTGVGPLPVVLFNGMPFEKEQLDPDELETITMHKILETTTFFQRAVYLGELSHDQDVVEYIMNQPNVVPRINSRILTAKREYLDLTASNNFYVDDFARFSALDSRGKTAAIANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKTSNNVRISMINNPSREISDSSTPVSRAIWAALQTQTSNSAKNFITKMVKEETAEALAAGVDIGEFSVGGMDVSLFKEVFESSRMDFILSHALYCRDVLKLKKGQRVVISNGRIIGPLEDSELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGEARIEYQFFEDKHSAIKLKPKEGETYYDVVAVVDPVTREAQRLAPLLLVLAQLINMSLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTADNSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDSIVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPTTVDTIVMANLGYFQLKANPGAWILRLRKGRSDDIYRIYSHDGTDSPPDANDVVVILNNFKSKIIKVKVQKKADMANEDLLSDGTNENESGFWDSFKWGFSGQKTEEVKQDKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMAKKYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQTLFQEEKELGTLHEEETQEGSQKHEEL
Protein: Histidine decarboxylase (EC 4.1.1.22) (A7KBS5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MQPQEYMLRGKEMVEYIHQYLTGIRERRVLPDVQPGFMRPLLPSSAPYEPEDWSTIMQDVENIIMPGVVHWQSPHMHAYFPALNSWPSLLGDMLADAINCLGFTWASSPACTELEMCVLDWLCKALGLPDHYLHHHPQSTGGGILQSTVSECTLVALLAARKDRILQMKSEATHTDTDESVLNSRLVAYASDQAHSSVEKAGLISLVKIRFLQTDAVFSLRGETLQRAVEEDRRSGLIPVMVCATLGSTGVREGLWLHVDAAYAGSALLCPELRYFLDGIQFADSFVFNPSKWMLVHFDCTAFWVKNKMKLQQTFTVDPLYLRHDNSNATDFMHWQIPLSRRFRSLKLWFVIRSFGLKKLQEHIRHGVEMAKLFESLVRKDTHFQIPAQRHLGLVVFCLRAGNAATQELLRKLTRSGRMFLIPAAVGNQLILRFSVTSQLTTEQDIRRDWSLIQQAAREVLQSGVVTRQPSVTSDPESEPEPLTIHTEPMLDQRLVRQGQRRAVRSYSCSAELPPAPGRTQTHRDAPLQLIPEQPERPQHRRLLKFXSVPSLAQVWAQCGMQQLHHPFRRGLITSRASCFTCPPLPEGTPLPTK
Protein: Fatty alcohol:caffeoyl-CoA acyltransferase (EC 2.3.1.-) (Fatty alcohol:caffeoyl-CoA caffeoyl transferase) (Q9FFQ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the synthesis of alkyl hydroxycinnamates in root waxes. Functions as a fatty alcohol:hydroxy cinnamoyl-CoA acyltransferase with apparent preference for caffeoyl-CoA.
Interaction partners:
- Cytochrome P450 86A7
- Omega-hydroxypalmitate O-feruloyl transferase
- Cytochrome P450 86A4
- Cytochrome P450 86A8
- Cytochrome P450 like protein
- Cytochrome P450 704B1
- At3g10570
- Cytochrome P450, family 77, subfamily A, polypeptide 9
- F21B7.2
- Cytochrome P450 superfamily protein
Sequence:
MADSFELIVTRKEPVLVSPASETPKGLHYLSNLDQNIAIIVKTFYYFKSNSRSNEESYEVIKKSLSEVLVHYYPAAGRLTISPEGKIAVDCTGEGVVVVEAEANCGIEKIKKAISEIDQPETLEKLVYDVPGARNILEIPPVVVQVTNFKCGGFVLGLGMNHNMFDGIAAMEFLNSWAETARGLPLSVPPFLDRTLLRPRTPPKIEFPHNEFEDLEDISGTGKLYSDEKLVYKSFLFGPEKLERLKIMAETRSTTFQTLTGFLWRARCQALGLKPDQRIKLLFAADGRSRFVPELPKGYSGNGIVFTYCVTTAGEVTLNPLSHSVCLVKRAVEMVNDGFMRSAIDYFEVTRARPSLTATLLITSWAKLSFHTKDFGWGEPVVSGPVGLPEKEVILFLPCGSDTKSINVLLGLPGSAMKVFQGIMDI
Protein: Allantoicase (EC 3.5.3.4) (Allantoate amidinohydrolase) (Protein EARLY ZYGOTE EXPRESSED 3) (P82678)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Catalyzes the degradation of allantoate to (-)-ureidoglycolate and (+)-ureidoglycolate to glyoxylate.
Interaction partners:
Sequence:
MASTSHNPFYAAMQPQAQHWGATSPTSTGAGYDRPSAGYPAYTGYAAAGTSHPAPSSSSPSTALALYNPSSLYGLYYNEAVHGPFATGLQSNPFTPGLAPLSTVSRPSYATEDPLRQRYPATSANPHDPLNWITEDLFAIRMERAAISQQRTPLRSASVAAR
Protein: Aminomethyltransferase folate-binding domain-containing protein (O53825)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MAAVPAPDPGPDAGAIWHYGDPLGEQRAGQADAVLVDRSHRAVLTLDGGDRQTWLHSISTQHVSDLPEGASTQNLSLDGQGRVEDHWIQTELGGTTYLDTEPWRGEPLLAYLRKMVFWSMVTPRAADMAVLSLLGPRLAEERVLDALGLDVLPAEWLAVPLAGGGIVRRMPDGLAGQIELDVVVKRGDRADWQRRLTQAGVRPAGIWAYEAHRVAHRVPARRPRLGVDTDERTIPHEVGWIGGPGAGAVHLNKGCYRGQETVARVHNLGRPPRMLVLLHLDESVQRPSTGDAVLAGGRTVGRLGTVVEHVELGPVALALLKRGLPGDTALVTGPEAEVAAVIDVDSLPPADDVGAGRRAVERLRGGIR
Protein: Protein pelota (P48612)
Organism: Drosophila melanogaster (Fruit fly)
Function: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of pix and HSB1, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (By similarity). Together with HBS1 and in presence of pix, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (By similarity). Required prior to the first meiotic division for spindle formation and nuclear envelope breakdown during spermatogenesis. Together with HBS1, promotes spermatid individualization during spermatogenesis. Required for ovarian germ line stem cell self-renewal and oocyte development during oogenesis. Together with HSB1, required for transposon silencing in the ovary and testis. As part of the Pink1-regulated signaling, is recruited to damaged mitochondrial and is required for recruitment of autophagy receptors and induction of mitophagy. Required for normal eye patterning and for mitotic divisions in the ovary.
Subcellular location: Nucleus {ECO:0000269|PubMed:30824860}. Cytoplasm {ECO:0000269|PubMed:16280348, ECO:0000269|PubMed:30824860}.
Interaction partners:
- Protein HBS1
- Protein Pixie
- Eukaryotic translation release factor 3, isoform A
- Small ribosomal subunit protein RACK1
- Ribosomal protein S30, isoform A
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein eL38
Sequence:
MKLLGKYVDKGMQGNVTLVPEESEDMWHAYNLIAKGDSVRSTTIRKVQNETATGSSTSSRVRTTLTIAVESIDFDTQACVLRLKGRNIEENQYVKMGAYHTLDLELNRKFELRKPEWDTIALERIEMACDPTQSADVAAVVMQEGLAHVCLITASMTLVRSKIEVSIPRKRKGSVQQHEKGLAKFYEQVMQSILRHVNFDVVKCVLIASPGFVRDQFYDYMFQQAVKMDYKLLLDNKSKFMLVHASSGFKHSLREILQDPAVLAKMSDTKAAGEVKALEQFYMMLQCEPAKAFYGKKHVLQAAESQAIETLLISDNLFRCQDVSLRKEYVNLVESIRDAGGEVKIFSSMHISGEQLAQLTGIAALLRFPMPELEDSDDDDDEDGAAGGVADSDSD
Protein: Disease resistance protein RPP1-WsB, putative (Toll-Interleukin-Resistance (TIR) domain family protein) (Q9FVT9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 1
- CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
- Probable disease resistance protein At5g45510
- Marker for oxidative stress response protein
- ATP binding protein
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Sequence:
MASSSSLSLSFPSSSLSRTWDYDVFPSFHGEDVRKAFLSQILKKEFGRKAINFFVDHEMERGEFIGPVLKQAIKGSKIALVLLSKNYASSWCCLDELVEIMKKESGQTVITIFYEVDPNEVKKQTGDFGKAFKETCQGKTEEKVQTWRKALEGVGLATIAGFHSSNWFVFFI
Protein: Tight junction protein 2 (A0A8I6AP88)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
Interaction partners:
Sequence:
MEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEMMDEFDGRSFRSGYSERSRHSSHDMLSHSWEDSRERGRPHQRAQSRERERSRGRSLERGLDHEDYGRSHERSRGRSLERGLDRDFVSRDYSRGRSIDRDYDRDYERSYHQAYEPDYEGRYSPSYDRRAHPETRYERSRSREHLRSRSPTPESRSRQEHKGQHDPDRPIGVLLTKSKANEEYGLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIPSLNDSDSEVEDISEIESNRSFSPEERRQQYSDQEYHSSTEKLKERPSSREETSGRMSRMGATPTPFKSTGDITAAGVTEANKEPRSQEESPVPQPRTASRVFLRPSPEDEAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSGVKKNIRKSREDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLFGPIADIAMERLTTELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGIKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQQQQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEEVRNQNREDSFNYSKSNLSAMAGSEIPGGSTKGCPPPIAVKPAFGRSILKPSTPVPMPESEEVGESTEEQEEAPKSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPQHMSSRPPEPQKAPSRLYQDTRGSYGSDPEEEEEYRQQLAAHSKRGYYSQPSRYRDTEL
Protein: At1g60280 (NAC domain containing protein 23) (T13D8.17 protein) (O80751)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- C2H2 and C2HC zinc fingers superfamily protein
- C2H2 and C2HC zinc fingers superfamily protein
- At5g41090
- C2H2 type zinc finger transcription factor family
- Zinc finger protein WIP6
- Nuclear transcription factor Y subunit C-5
- NAC domain protein
- Kinesin-like protein
- LOB domain-containing protein 10
- Protein RALF-like 3
Sequence:
MKVEDEATYELIKDELMKAEDEATYWLIKEELIKAEDDVIISRYLKRMIVNGDSWPDHFIEDVDVFNKNPNEEFHSQSPRFVIVKPRTENCGRTDGCQSGCWRIIGRDKLIKSKETGKILGFKKILKFCLKKKPREYKRSWVMEEYRLNNNLNCKQDHVICKIRFMFDAEISFLLAKHFSCLSTRSPLPANQLLPAYGVCFFDSEAEGAFYLETIIGYDGNTWPSYVTNDVYRLHPLTLVDPQDDKFKEFGTCIFANRTKTCGKTDECDGGGCWRIVEGHRVIKSKGKVLGYRRIFQFSENEEPRNVCEGEDPKKTAWFIEEYRPDENNKKDKVLCVIKFLIPLNQR
Protein: Glutamate dehydrogenase (EC 1.4.1.3) (Q8JG16)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MYRYFGELLSRGAGSALASGCVESALPASAALMRVRQYSEQPDDPNFFRMVEGFFDRGAAIVQDKLVEDLKSRETPEQKMKRVKGILRIIKPCNHVLSVSFPIKRDNGEWEVVEGYRAQHSQHRTPCKGGIRYSEEVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINVKNYSDNELEKITRRFTIELAKKGFIGPGIDVPAPDMSTGEREMSWI
Protein: RING-H2 finger protein ATL63 (EC 2.3.2.27) (Protein ARABIDOPSIS TOXICOS EN LEVADURA 63) (Protein ATL63) (RING-type E3 ubiquitin transferase ATL63) (Q9LUZ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 4
- Ubiquitin carboxyl-terminal hydrolase 6
- Ubiquitin carboxyl-terminal hydrolase 14
- Ubiquitin carboxyl-terminal hydrolase 15
Sequence:
MSEEDGGSMSVKSSLSSFLKILSSYNSNVLLAALVFLLLVVLFVLLLHFYARFFWSPSHQDFSAAARHRRRRRRNRRRTVTTTRIIPSLPLGGFDDGVSSPAATATRDDKGLDSSVISSIPLFVYEENEEEEDEEEECVICLGLWEAGDFGRKLRNCGHGFHVECIDMWLSSHSTCPLCRSPVLAAVSDEENLKLAVNAVEEEAEVRLQMSPAGENESNVSGDRRVSLSLSVMEDDLKTGDDDGEEEVRIEVFDDDEEINDGGTRSDRRRSMSMTSSASSSLMRMLSSSSSRSERNKVFPTARQDSSK
Protein: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) (B5X1I3)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
- RNA-binding protein 45
- RNA-binding protein 45-like
- 6-phosphogluconolactonase
- GDH/6PGL endoplasmic bifunctional protein-like
- GDH/6PGL endoplasmic bifunctional protein-like
- Glucose-6-phosphate isomerase
- Glucose-6-phosphate isomerase
- Glucosamine-6-phosphate isomerase
- Glucosamine-6-phosphate isomerase
- Glucosamine-6-phosphate isomerase
Sequence:
MAGRKLSAIPLSRSEVFGELRKELHDDKEFHHSDAHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDAIKTASMPYMKVADSEAERLSVFFSRNSYVSGKYTEESAFSNLHTHLLSLPGGGKANRLFYLALPPSVYHDVTKNIKHHCMSTKGWSRVIVEKPFGRDLQSSEELSTHLSSLFTEDQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSIACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIAPITMSDVVLGQYVGDPEGEGDAKLGYLDDPTVPKGSTQATFTTAVLYVHNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFGAQCRRNELVVRVQPNEAVYAKMMSKKPGVYFHPEETELDLTYKSRYKDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKPPPTPYIYGSRGPTEADELSKRVGFHYEGTYKWVNPHRL
Protein: Fibrillarin, putative (Q388E0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nucleolar protein 56
- Nucleolar RNA binding protein, putative
- H/ACA ribonucleoprotein complex subunit 2
- Uncharacterized protein
- Nrap protein domain-containing protein
- HEAT repeat-containing protein 1
- Centromere/microtubule binding protein cbf5, putative
- 50S ribosomal protein L7Ae, putative
- U3 small nucleolar ribonucleoprotein protein IMP3, putative
- Periodic tryptophan protein 2, putative
Sequence:
MRGCYLLAGKDTLATKSLVPGVSIYGEKRVSGTIAGETESCEFRVWNPYRSKLAAAIYAGVAQIYMEPGSTVLYLGAASGTTVSHVSDLVGPEGVVYAVEFSHRSGRDLEEMSKRRSNIVPILEDARYPQKYRMLIPRLVDCIFMDVAQPDQARILALNAQHFLKQNGGFVISIKANCIDSTADSATVFASEVQKLKDSGLRPKEQASLEPFERDHAVVTGYYKSPPQ
Protein: ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP) (P48410)
Organism: Mus musculus (Mouse)
Function: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Has fatty acyl-CoA thioesterase (ACOT) and ATPase activities. Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs.
Subcellular location: Peroxisome membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33897}. Lysosome membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33897}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33897}.
Interaction partners:
- ATP-binding cassette sub-family D member 3
- ATP-binding cassette sub-family D member 2
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein PEX13
- Peroxisomal membrane protein 11B
- Peroxisomal membrane protein PMP34
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX16
- Peroxisomal membrane protein PEX14
- Peroxisomal membrane protein 2
Sequence:
MPVLSTPRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPARGPQVPAGEPTQEASGATATKAGMNRVFLQRLLALLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERTEAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVKHCRFKRTGDLEEAQAGPGVMVQSGVHVEGPLKIQGQVVDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQGRLQELRQILGEAAAPVQPLVPGVPT
Protein: Neuronal pentraxin receptor (Q99J85)
Organism: Mus musculus (Mouse)
Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Atrial natriuretic peptide receptor 3
- Atrial natriuretic peptide receptor 1
- Atrial natriuretic peptide receptor 2
- Plasma membrane calcium-transporting ATPase 2
- Chromobox protein homolog 6
- Natriuretic peptides A
Sequence:
MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGTDNASAASAAGGSGPQRSLSALHSAGGSAGPSVLPGEPAASVFPPPPVPLLSRFLCTPLAAACPSGAEQGDAAGERAELLLLQSTAEQLRQTALQQEARIRADRDTIRELTGKLGRCESGLPRGLQDAGPRRDTMADGAWDSPALLLELEDAVRALRDRIERIEQELPARGNLSSAPAPAMPTALHSKMDELECQLLAKVLALEKERAALSHGSHQQRQEVEKELNALQGRVAELEHGSSAYSPPDAFKVSIPIRNNYMYARVRKALPELYAFTACMCVRSRSGGSGQGTPFSYSVPGQANEIVLLEAGLEPMELLINDKVAQLPLSLKDSNWHHICISWTTRDGLWSAYQDGELRGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGMANCTGPLMGNVLPWEDKLVEAFGGAKKAAFDVCKGRAKA
Protein: Lycopene epsilon cyclase, chloroplastic (EC 5.5.1.18) (Protein LUTEIN DEFICIENT 2) (Q38932)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in carotenoid biosynthesis. Catalyzes the single epsilon-cyclization reaction which converts lycopene to delta-carotene and neurosporene to alpha-zeacarotene. Required for lutein biosynthesis.
Subcellular location: Plastid, chloroplast membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Zeta-carotene desaturase, chloroplastic/chromoplastic
- Prolycopene isomerase, chloroplastic
- Phytoene synthase 1, chloroplastic
- 15-cis-zeta-carotene isomerase, chloroplastic
- 15-cis-phytoene desaturase, chloroplastic/chromoplastic
- Protein LUTEIN DEFICIENT 5, chloroplastic
- Violaxanthin de-epoxidase, chloroplastic
- Zeaxanthin epoxidase, chloroplastic
- Carotene epsilon-monooxygenase, chloroplastic
- Lycopene beta cyclase, chloroplastic
Sequence:
MECVGARNFAAMAVSTFPSWSCRRKFPVVKRYSYRNIRFGLCSVRASGGGSSGSESCVAVREDFADEEDFVKAGGSEILFVQMQQNKDMDEQSKLVDKLPPISIGDGALDLVVIGCGPAGLALAAESAKLGLKVGLIGPDLPFTNNYGVWEDEFNDLGLQKCIEHVWRETIVYLDDDKPITIGRAYGRVSRRLLHEELLRRCVESGVSYLSSKVDSITEASDGLRLVACDDNNVIPCRLATVASGAASGKLLQYEVGGPRVCVQTAYGVEVEVENSPYDPDQMVFMDYRDYTNEKVRSLEAEYPTFLYAMPMTKSRLFFEETCLASKDVMPFDLLKTKLMLRLDTLGIRILKTYEEEWSYIPVGGSLPNTEQKNLAFGAAASMVHPATGYSVVRSLSEAPKYASVIAEILREETTKQINSNISRQAWDTLWPPERKRQRAFFLFGLALIVQFDTEGIRSFFRTFFRLPKWMWQGFLGSTLTSGDLVLFALYMFVISPNNLRKGLINHLISDPTGATMIKTYLKV
Protein: Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M) (Q55C21)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175}.
Interaction partners:
- Methionine aminopeptidase 1
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL24
- sphingolipid 4-desaturase
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS8
Sequence:
MSEIQPKTEVPPKTVEEEEESDDEEDNTKVTEGGNPTGGEGAAKKKKKKNKKKKKAAPVASAADIIDSKPIPSGLVQTNPPTIPVSKQFSNGVYPMGEIQEYRDSNSYRTTSEEKRLEERIHANIYNDVRRAAEVHRQVRKYVQGIVKPGLGLTELVESLENASRTLIEADGLKAGIAFPTGVSLNHIAAHFTPNTGDKTVLKKDDVLKIDFGTHVNGYIIDCAFTVTFDEKYDKLKDAVREATNTGIYHAGIDARLGEIGAAIQEVMESHEIELNGKTYPIRSIRNLNGHSIRPYVIHGGKTVPIVRGGEMTKMEEGEFYAIETFGSTGRAQVIEDLECSHYMKTDYQTTVRLPKAKQLLQYINKNYDTLCFCRRWLDRAGEDKHILALNNLCDLGIIQRHAPLVDSKGSYVAQYEHTLLLKPTAKEVLSRGDDY