wanglab/gogpt-training-data huggingface dataset:
Protein: N-alpha-acetyltransferase 15, NatA auxiliary subunit (Gastric cancer antigen Ga19) (N-terminal acetyltransferase) (NMDA receptor-regulated protein 1) (Protein tubedown-1) (Tbdn100) (Q9BXJ9)
Organism: Homo sapiens (Human)
Function: Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.
Subcellular location: Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
Interaction partners:
- N-alpha-acetyltransferase 10
- Huntingtin-interacting protein K
- N-alpha-acetyltransferase 50
- N-alpha-acetyltransferase 11
- N-alpha-acetyltransferase 25, NatB auxiliary subunit
- N-alpha-acetyltransferase 20
- N-alpha-acetyltransferase 16, NatA auxiliary subunit
- N-alpha-acetyltransferase 35, NatC auxiliary subunit
- N-alpha-acetyltransferase 30
- N-alpha-acetyltransferase 38, NatC auxiliary subunit
Sequence:
MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAEHGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWAYYKGLEKALKPANMLERLKIYEEAWTKYPRGLVPRRLPLNFLSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYKDKEKVAIIEELVVGYETSLKSCRLFNPNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFINSKCAKYMLKANLIKEAEEMCSKFTREGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKCHEIERHFIEITDDQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAARIAIEIYLKLHDNPLTDENKEHEADTANMSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQKKKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKFLTPLKNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTAVCESKDLSDTVRTVLKQEMNRLFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQKRAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMPPGYEEDMKITVNGDSSAEAEELANEI
Protein: Vacuolar protein sorting-associated protein 41 (Vacuolar morphogenesis protein 2) (P38959)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for vacuolar assembly and vacuolar traffic. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
Subcellular location: Vacuole {ECO:0000305}.
Interaction partners:
- Vacuolar protein sorting-associated protein 3
- Vacuolar morphogenesis protein 6
- Vacuolar morphogenesis protein 7
- E3 ubiquitin-protein ligase PEP5
- Vacuolar membrane protein PEP3
- Syntaxin VAM3
- Vacuolar protein sorting-associated protein 16
- Vacuolar protein sorting-associated protein 33
- Ypt/Rab-type GTPase YPT7
- t-SNARE VTI1
Sequence:
MTTDNHQNDSVLDQQSGERTIDESNSISDENNVDNKREDVNVTSPTKSVSCISQAENGVASRTDESTITGSATDAETGDDDDDDDDDDDEDEDDEDEPPLLKYTRISQLPKNFFQRDSISSCLFGDTFFAFGTHSGILHLTTCAFEPIKTIKCHRSSILCINTDGKYFATGSIDGTVIIGSMDDPQNITQYDFKRPINSVALHSNFQASRMFVSGGMAGDVVLSQRNWLGNRIDIVLNKKKKKKTRKDDLSSDMKGPIMGIYTMGDLILWMDDDGITFCDVPTRSQLLNIPFPSRIFNVQDVRPDLFRPHVHFLESDRVVIGWGSNIWLFKVSFTKDSNSIKSGDSNSQSNNMSHFNPTTNIGSLLSSAASSFRGTPDKKVELECHFTVSMLITGLASFKDDQLLCLGFDIDIEEEATIDEDMKEGKNFSKRPENLLAKGNAPELKIVDLFNGDEIYNDEVIMKNYEKLSINDYHLGKHIDKTTPEYYLISSNDAIRVQELSLKDHFDWFMERKQYYKAWKIGKYVIGSEERFSIGLKFLNSLVTKKDWGTLVDHLNIIFEETLNSLDSNSYDVTQNVLKEWADIIEILITSGNIVEIAPLIPKKPALRKSVYDDVLHYFLANDMINKFHEYITKWDLKLFSVEDFEEELETRIEAASEPTASSKEEGSNITYRTELVHLYLKENKYTKAIPHLLKAKDLRALTIIKIQNLLPQYLDQIVDIILLPYKGEISHISKLSIFEIQTIFNKPIDLLFENRHTISVARIYEIFEHDCPKSFKKILFCYLIKFLDTDDSFMISPYENQLIELYSEYDRQSLLPFLQKHNNYNVESAIEVCSSKLGLYNELIYLWGKIGETKKALSLIIDELKNPQLAIDFVKNWGDSELWEFMINYSLDKPNFTKAILTCSDETSEIYLKVIRGMSDDLQIDNLQDIIKHIVQENSLSLEVRDNILVIINDETKKFANEFLKIRSQGKLFQVDESDIEINDDLNGVL
Protein: Tripeptidyl-peptidase 2 (TPP2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl peptidase II) (TPPII) (Q09541)
Organism: Caenorhabditis elegans
Function: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (By similarity). Has a role in regulation of fat storage.
Interaction partners:
Sequence:
MIVIRNWQRISYLSFCRFSTRSLSIQQFQKTPLLLVVRQQGSARLKMTSSPPEIVPQQPLDALLLNKTDTEQEIFLTKYPNYDGRDILIAILDTGVDPSLPGMQVTTTGERKMFDVIDCSGAGDVDTSITRTVKDGVIEGISGRKLAIPEKWKCPTGQYHVGLKPIFELYTKGVKSRVISERKEDVVGPSHNIAASEALKQLTEHEKVVGGTSEKTSDKWAREDFACKVDFLKSMASVADVGPVADVVTWHDGEMWRVCIDTSFRGRLGLGNVLGTFRETGDYAYLTNKDSVVYTVRVSPDGNLTEIVVPSGAHGSHVAGIAAANYPDNPQKNGLAPGAKILSLNIGDHRLGAMETGQAMTRAFNMCAELNVDIINMSFGEGTHLPDVGRVIEEARRLINRRGVIYVCSAGNQGPALSTVGAPGGTTTGVIGIGAYLTSESADTLYGVYKPVESSIYPWSSRGPCQDGKLGVSLVAPAAAFAGVPQYCRQSMQMMNGTSMSSPNAAGNVACMLSGLKQNNLKWTPYTVRMALENTAYMLPHIESFSQGQGMIKIATAYEKLSEILVNKVFPPRLTHFEINVSNHCKKSKGVYVREPNWNGPQEFTIGVEPIFQNHLSDNNLPAISFEKQIILQSTAPWVSHPQTMFVVAQERTMVVTVDASKAPKGANYTEIVGIDTADPSLGPIFRIPVTVINPEKVAVDQYTSRLVGKSGVTERRFVEVPSWATSAKITLRSTNKDEMDRFTLHTVYIEDDKCSRNTETQKIQGPIGNEWSKSITVQGGKTLEACVVRAWSRGKNPVDVDMTIDFFGVKKPTSISLIHGATNTPIRFQAAPTKSIDVSPSISLKSLVVSLKPQSAKVEPLGPRDMFLTSGLQINRLLLTYQLKVQKPSEVQLQLAGLTPYLYESPVDCVLFQIFGANKSFVGASSSYPDRWTQKLEKGDYTIQAQIRYPDDQVLQGMKELPLLVHVKLGNKISVDLAASASDATLGKECKFAGKALLPNQEMTVYAMNIADDKLPKTIVPTSGSFLAGTFSALKDSDLSDVDKSEVIYFLSEYSTRPTKGLSMVTTKKDTNQNQEMTDAIRDLEVSWVQKLTDEKAAKEFFEACLQKYPDHLPLLQNRVKQLMQAKLVDQTPENVQKIIELCGQILQITKPNETLQFSSVKQEHDDDLLTVDKWLALTGGSEDQRKDVVKLISQFEERKKSIILALQALSSLEQDIEVRKSKFDVPASLRFGGITPLIFGGKQGEVINKKSEGYEALKSKSEQIDATVSEELKKLDSNWTGNQFYVKLLVWLSADDTKTALISAKHAAALGQFGRCAKLLNKAGDELKSSATDSQAVDTSLAEVCESLEWNHLATHFKNSALIKNRTSYRLF
Protein: cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase A (PDEase A) (EC 3.1.4.35) (EC 3.1.4.53) (3',5'-cyclic-nucleotide phosphodiesterase) (3':5'-CNP) (Phosphodiesterase 1) (DdPDE1) (cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 1) (P12019)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Phosphodiesterase which displays a preference for cAMP over cGMP. Involved in the degradation of extracellular cAMP. Maintains the responsiveness of cells to the chemoattractant cAMP during the aggregation phase of development.
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:17040207}. Cell surface {ECO:0000269|PubMed:17040207}.
Interaction partners:
- 3',5'-cyclic-nucleotide phosphodiesterase regA
- 3',5'-cyclic-AMP phosphodiesterase 4
- Cytosolic purine 5'-nucleotidase
- GMP synthase
- Adenosine kinase
- Hypoxanthine-guanine phosphoribosyltransferase
- Adenylosuccinate lyase
- Guanylate kinase
- Inosine triphosphate pyrophosphatase
- Adenylate kinase
Sequence:
MALNKKLISLLLLIFIILNIVNSHQQEDCDDDDEDIGISAERSERRSVKNSNDGSNFYNLNDYYTPENWNYYSGSFATKDCRDASYITIPLGTTGGLDEGNLSSFLLTKKGSNLFIALDAGTVWQGVRRLTTFKYFNTLFNITYPSWAVLPEQRTSWFLKNHVMSYFIGHSHLDHVGGLILVSPEDYLAKNWIDVQPPINNGIMGLIRKLGFKPTDFTSSSILQKKTIMGLPSTINSISTNLFNNQVWPNLPSFGRYQYFSLASGIEYPFTELVPYNATTMSLVANEFPFSVKVKPFELCHDNLISTSFLFTDSISGEQIAFFSDTGVPSSVACDWEGKIYAVWKQIKIDKLKAIYIETSFPNNTPDSAMFGHLRPRDVMKLMDQLLVQSIQTSPPMTNLKHVKLIIEHIKPQVAEDPNGWTTQRVIYQQLKEANNNGVRIIIPNQGDPICI
Protein: Down syndrome cell adhesion molecule 1, isoform W (Q0E9I8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVQQFYESEVNNEYVIRGNAAVLKCSIPSFVADFVQVVSWQDEEGQLYGSLGDQQGTDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPISSAVPKVVSLAKFDMKTYSGSSTMALLCPAQGYPVPVFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIMPFDFGEDVINELDMVSAYCTVNRGDLPVDIAWTKNGGRIYTNDGLIVTRNSQRISVLSIESVRARHAGNYSCVATNSAGETRQSAILAVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPSRDLPELSAEDTIRIILSNLNLVVPVVAALLVIIIAIIVICILRSKGNHHKDDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQQANGAGFTAYDTMAV
Protein: Tyrosinase (EC 1.14.18.1) (A7BHQ9)
Organism: Pholiota nameko
Function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Interaction partners:
Sequence:
MSRVVITGVSGTIANRLEINDFVKNDKFFSLYIQALQVMSSVPPQENVRSFFQIGGIHGLPYTPWDGITGDQPFDPNTQWGGYCTHGSVLFPTWHRPYVLLYEQILHKHVQDIAATYTTSDKAAWVQAAANLRQPYWDWAANAVPPDQVIVSKKVTITGSNGHKVEVDNPLYHYKFHPIDSSFPRPYSEWPTTLRQPNSSRPNATDNVAKLRNVLRASQENITSNTYSMLTRVHTWKAFSNHTVGDGGSTSNSLEAIHDGIHVDVGGGGHMGDPAVAAFDPIFFLHHCNVDRLLSLWAAINPGVWVSPGDSEDGTFILPPEAPVDVSTPLTPFSNTETTFWASGGITDTTKLGYTYPEFNGLDLGNAQAVKAAIGNIVNRLYGASVFSGFAAATSAIGAGSVASLAADVPLEKAPAPAPEAAAQPPVPAPAHVEPAVRAVSVHAAAAQPHAEPPVHVSAGGHPSPHGFYDWTARIEFKKYEFGSSFSVLLFLGPVPEDPEQWLVSPNFVGAHHAFVNSAAGHCANCRSQGNVVVEGFVHLTKYISEHAGLRSLNPEVVEPYLTNELHWRVLKADGSVGQLESLEVSVYGTPMNLPVGAMFPVPGNRRHFHGITHGRVGGSRHAIV
Protein: CRISPR system Cmr endoribonuclease Cmr4 (EC 3.1.-.-) (CRISPR type III-B/RAMP module RAMP protein Cmr4) (Target RNase Cmr4) (Q8U1S9)
Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), formerly called psiRNA (prokaryotic silencing) in this organism. Part of the Cmr ribonucleoprotein complex which has divalent cation-dependent endoribonuclease activity specific for ssRNA complementary to the crRNA (target RNA), generating 5' hydroxy- and 3' phosphate or 2'-3' cyclic phosphate termini. This is probably the subunit that cleaves the target RNA. Cmr complex does not cleave ssDNA complementary to the crRNA. Cleavage of target RNA is guided by the crRNA; substrate cleavage occurs a fixed distance (14 nt) from the 3' end of the crRNA. In vitro reconstitution shows Cmr1-2 and Cmr5 are not absolutely necessary for target cleavage.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19945378}.
Interaction partners:
- CRISPR system Cmr subunit Cmr5
- CRISPR system Cmr subunit Cmr6
- CRISPR system Cmr subunit Cmr2
- CRISPR system Cmr subunit Cmr3
- CRISPR system Cmr subunit Cmr1-1
- TIGR01897 family CRISPR-associated protein
- CRISPR-associated endonuclease Cas1
- CRISPR-associated endoribonuclease Cas6
- CRISPR system Cmr subunit Cmr1-2
- CRISPR-associated helicase Cas3
Sequence:
MKAYLVGLYTLTPTHPGSGTELGVVDQPIQRERHTGFPVIWGQSLKGVLRSYLKLVEKVDEEKINKIFGPPTEKAHEQAGLISVGDAKILFFPVRSLKGVYAYVTSPLVLNRFKRDLELAGVKNFQTEIPELTDTAIASEEITVDNKVILEEFAILIQKDDKGILESVVKAIEQAFGNEMAEKIKGRIAIIPDDVFRDLVELSTEIVARIRINAETGTVETGGLWYEEYIPSDTLFYSLILVTPRAKDNDMALIKEVLGKINGKYLQIGGNETVGKGFVKVTLKEVTNNGGTHAK
Protein: lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) (A1Z6X6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glyoxylate reductase/hydroxypyruvate reductase
- NADH dehydrogenase 23 kDa subunit
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- monoamine oxidase
- L-serine deaminase
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase iron-sulfur protein 6
- RH44771p
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- AT18465p
Sequence:
MGDVTGLSNAQADELCQKPDSSTKDFLFQQTMYRIKDPRKSLPFYTGVLGMTLLVKLDFPEAKFSLYFLGYENATDVPKDPKQRRSWALSRKATIELTHNWGTERDPDQNYHTGNTDPRGFGHIGIMVPDVYAACQRFQELGVDFVKKPDDGRMKGLAFIKDPDGYWIEIFNAHSV
Protein: E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) (Q86Y01)
Organism: Homo sapiens (Human)
Function: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 2
- Delta and Notch-like epidermal growth factor-related receptor
- Neurogenic locus notch homolog protein 3
- E3 ubiquitin-protein ligase Itchy homolog
- Neurogenic locus notch homolog protein 4
- Recombining binding protein suppressor of hairless
- E3 ubiquitin-protein ligase DTX3L
- Notch-regulated ankyrin repeat-containing protein
- Ankyrin-2
Sequence:
MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA
Protein: Candida glabrata strain CBS138 chromosome L complete sequence (Q6FL83)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MKFNCVLLAAFMVAAAPSPKHDHEDRHAIKRDVDVVTVVEYVGADDGNGFDVKTSTKAQPSSVATSTRKTLQPSSSSSSSSSSSNGGSGSFKDGTIPCSQFPNVDNVVAVDWVGLGGWASVMNFDGSYGQSCSDGLYCSYACKPGYSKTQWPSEQPSDGKAIGGLLCKNGYLYRTNTNADSLCQQDIQSANAKNTLGKSVALCRTDYPGSENMVVPTVVDAGSSQPMSVIDSDSYYQWQGKKTSAQYYVNNAGVSKEQGCVWGDAASGNGNYAPLIFGSGKSNGVTYLSITKNPNSNSAANFNVKIEGADGADVGGTCVYENGQFSSGSDGCTVAVKSGVANFIFY
Protein: exo-alpha-sialidase (EC 3.2.1.18) (A0PJS4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MASKSYPEAQRPPPAQTVLFQQKDGKTYRIPALIYISDGQTFLAFAEERSTPRDSDAKVLVMRKGSLHNGSLQWTSAQTLTSACLPDHRTMNPCPVYERKSKTIYLFFICISGNTTEYHQIAMGRNRARLCYITSADYGETWSELTDLTNSVIGDEIHNWATFAVGPGHGIQMKSGRLIIPAYVYYVHCRCFPFNFPLIVRPHALSFYSDDCGVTWQMGGKIQMKSCECEMAEIIDHADQSHLYCNARSTCGYRIEALSETSGAAFDNPHVARKLVEPRHGCQGSVLSFPVPQPLDEEEKKPTDCLTQSDSKTWLLYSHPTNKKKRKDLGVYLNKSPLNASGWSRPWIIYKGPSGYSDLTQCEERFGCLMECGEKSEIEGIAFVEFKLNDLLCS
Protein: Non-histone chromosomal protein H6 (Histone T) [Cleaved into: Oncorhyncin-3 (Oncorhyncin III)] (P02315)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Non-histone protein that probably binds to the inner side of nucleosomal DNA, altering the association between the DNA and the nucleosome octamer.
Subcellular location: Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: [Oncorhyncin-3]: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MPKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAGNAK
Protein: TEA domain transcription factor 1 (H0YEJ9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR002603}.
Interaction partners:
Sequence:
MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
Protein: Cycloartenol synthase 2 (EC 5.4.99.8) (Q8W3Z3)
Organism: Betula platyphylla (Asian white birch)
Function: Oxidosqualene cyclase converting oxidosqualene to cycloartenol.
Interaction partners:
Sequence:
MWKLKIAEGGSPWLRTLNNHVGRQVWEFDPKLGSPEELAEIERARETSLKVRFEKKHSSDLLMRIQFAKENPRGAVLPQVKVNETEDVTEEMVTRMLRRAISFHSTLQAHDGHWAGDYGGPMFLMPGLVITLSITGALNTVLSEEHKKEMCRYLYNHQNKDGGWGLHIEGPSTMFGTVLSYVTLRLLGEGANDGQGAIERGRKWILDHGSATAIISWGKMWLSVLGAFEWSGNNPLPPEIWLLPYMLPVHPGRMWCHCRMVYLPMSYLYGKRFVGPITPTVMSLRKELYSVPYHEIDWNQARNLCAKEXLYYPHPLVQDILWASLHKLVEPVLMRWPGKRLREKALRTVLEHIHYEDENTRYICIGPVNKVLNMLCCWVEDPNSEAFKLHLPRINDYLWIAEDGMKMQGYNGSQLWDTAFAVQAIISTNLFEEYGPTLEKAHMYIKKSQVREDCPGDLDFWYRHISKGAWPFSTADHGWPISDCTAEGLKAALLLSKIPPDVVGEPLVEERLYDAVNVILSLQNADGGFATYELTRSYPWLELINPAETFGDIVIDYNYVECTSAAIQALTSFKKSYPKHREEEVDVCIKRAAMFTEKIQASDGSWYGSWGVCFTYGTWFGVKGLVAAGKNFNDCFGIRKACDFLLSKQLPSGGWGESYLSCQNKVYSHVEGNRSHVVNTGWAMLALIEAGQAERDPTPLHRAARVLINSQMENGDFPQEEIMGVFNRNCMITYAAYRNIFPIWALGEYRCRVLQAP
Protein: Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) (Myocyte-activating factor) (P61329)
Organism: Mus musculus (Mouse)
Function: Involved in nervous system development and function. Promote neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Sodium channel protein type 5 subunit alpha
- Fibroblast growth factor receptor 1
- C-Jun-amino-terminal kinase-interacting protein 2
Sequence:
MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKRPVRRRPEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGRSRKSSGTPTMNGGKVVNQDST
Protein: Mcf2 proto-oncogene protein (Q7TNJ5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAVANPPRGKMRFRRNAASFPGSLHLVLVLRPTSFLQRTFTDIGFRFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIEKFAVTVKEMAQMLQSFGTELAETELPQDILSIEEILAGRAERYHLLKNDLTAVTKEGKVLLMNLQVPATEETVSSSLECTQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQEAVTQVEFLLSQQRELGDITGNLAQVKQRLKKLEILDDKSQELLTKARIVILRGHKLASNHHYALDLICQRCNELRYLSDILVNEIRTKRVQLSRTFKVHRLLQQARQCCDQGECLLASQGMDKFQTKEDAQKALQDVDNFLQMAMPFINYDIESLQYEFDVLLSPELKAQMQNIQLKLENIRSAFQNQQAGCKSLKEVPEGAFQNLVPASENVMRSRMIFFSPKHVGIGYSFFQACRIFLKVKKSWRQIRAQSNVKVEAVEDSQEKNSDQSPKLDNSLDILKNHVLDELIQTERAYVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPERVGPCFLERKDDFQMYAKYCQNKPRSELIWRKYSECAFFQECQRKLKHRLGLDSYLLKPVQRITKYQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINAYVGNINELGKMVLQGSFNVWLGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHCLKMEDVGITEHVKGDNRKFEIRYSEKEEIYIVQAPNVDVKMLWLKEIRKILVQQKELMTAKTQQDQALDQDQLFPQQQNAELCKSSPFCVCEETLFNATEAGAEVEQAGALIKVREAAVLAQAEASSAAWNGMLPSAEGAAAIAEHSYNYFSSNNDHGEDRTQMRHMSEVTF
Protein: Ent-cassadiene C11-alpha-hydroxylase 1 (EC 1.14.14.112) (Cytochrome P450 76M7) (Q69X58)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Enzyme of the diterpenoid metabolism involved in the biosynthesis of antibacterial oryzalides such as phytocassane. Can use ent-cassadiene as substrate, but not C11-alpha-hydroxy-ent-cassadiene, ent-pimaradiene, ent-sandaracopimaradiene, ent-kaurene, ent-isokaurene, syn-pimaradiene, syn-stemarene, syn-stemodene.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Nitrate reductase
- Nitrate reductase
- Nitrate reductase 1
- 4-coumarate--CoA ligase
Sequence:
MENSQVWLLWGALSVAVLFYLSTLRRRHAGGKPLPPGPTPLPLIGNLHLAGGTSFHHKLRDLARVHGPVMTLKLGLATNVVISSREAAIEAYTKYDRHLAARATPDTFRACGFADRSMVFIPSSDPRWKALRGIQGSHVFTPRGLAAVRPIRERKVGDLMAYLRAHAGEEVLLGQAMHTGLLNLVSFSYFSIDIVDMGSQMARDLREVVDDIISVVGKPNISDFYPFLRPLDLQGLRRWTTKRFNRVFSIMGDIIDRRLAHIRDNKPSHNDFLDSLLELMAAGKIDRVNVLDMLFEAFVAGADTMALTLEWVMAELLKNPGVMAKARAELRDVLGDKEVVEEADAARLPYLQAVLKEAMRLHPVGALLLPHFAVEDGVEVGGYAVPKGSTVLFNAWAIMRDPAAWERPDEFVPERFVERAPLLDFRGKDAEFMPFGSGRRLCPGLPLAERVMPFILASMLHTFEWKLPGGMTAEDVDVSEKFKSANVLAVPLKAVPVLIK
Protein: Lon peptidase 1, mitochondrial (K7ER27)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENP
Protein: Meloidogyne-induced cotton 15 (A7LJB0)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MACPPTHKVVKGELKNGSDDCLASLMYSNYQGAPVTIKKDSLPTPFAQNMMVDGLYGGLVYDVVRVATKIIPTENHIVWEDIVSILQPYDSSDNLPLSCGGAFSAEAHIHANGDGSLNLTAQIMWSGCK
Protein: Lipase lipl-4 (EC 3.1.1.-) (EC 3.1.1.3) (Lipase-like 4) (Q94252)
Organism: Caenorhabditis elegans
Function: Lysosomal lipase that regulates the metabolism of long-chain fatty acids, primarily in response to nutrient availability. The production of these lipid signaling mediators regulates various processes, including lipolysis, autophagy, mitochondrial beta-oxidation, which in turn control lifespan and adaptation to starvation. In response to fasting, promotes the production of omega-6 polyunsaturated fatty acids (PUFAs), which in turn activates autophagy resulting in lifespan extension. Produces oleoylethanolamide (OEA), a ligand for the lysosomal lipid chaperone lbp-8 which translocates into the nucleus where it activates the transcription of genes promoting longevity and activation of mitochondrial beta oxidation.
Subcellular location: Lysosome lumen {ECO:0000269|PubMed:25554789}.
Interaction partners:
- Nuclear hormone receptor family member nhr-80
- Fatty acyl-CoA reductase
- Nuclear hormone receptor family member nhr-49
- Fatty acid-binding protein homolog 8
- LIPaSe related
- Fatty acid synthase
- Delta
- Medium-chain acyl-CoA ligase ACSF2
- Forkhead box protein O
- Helix-loop-helix protein 30
Sequence:
MRESISDLMTVMIPLLIILLLSNYSKSVDLEFYLDTPELIKSWGYSVEIYNTTTKDGFILELHRIPYGREVPTSSDVNNSRPVIFLQHGFLCSSFDWVANSPHQSAGFVFADAGFDVWLGNFRGNTYSRKHVSLNPDKDPKFWDWSWDQISEYDLPAMIGKALEISGQESLYYTGFSLGTLTMFAKLSTDPKFSRKIKKYFALAPIGSIKHAHGVFLFLGRHFGKDYEEYVKKHGSDELFGSSLLFKKIVKYTCGLFDTLEEFCSDITLLFIGTANENWNQTRIPVYLAHTPAGSSSNVMAHLDQMFSYGGVPTFDMGEEKNLKAYGQKLPPQYNFTGIADVPIYLFWSDDDWLSTKQDLEETLFAQLNSQVVQGSFRIENYNHLHFIWGTNAASQVYNVITGIILQDDNT