wanglab/gogpt-training-data huggingface dataset:
Protein: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Q9VFE9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Diphthamide biosynthesis protein 3
- 2-
- diphthine methyl ester synthase
- GH01248p
- Eukaryotic translation elongation factor 2
- Diphthamide biosynthesis 4, isoform A
- Probable ATP-dependent RNA helicase CG8611
- LD17611p
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Probable ATP-dependent RNA helicase DDX56
Sequence:
MTSSETSASAFSSSDTAALERQAEVEQPVTLEQIWNENHRRSSVDWIRKSGYKRVCLQFPDDYLPHSNAISVGLKELLAPEDVKVFILADTTYGSCCVDEIAAAHVDADSVIHFGNACRSRAARLPVLYLYPELPLDVNVLLSKLQGLRAESIDRQVCVYLDIGYQHVYGEKLKKQLSEILEPKELLLELFPPIEAESTTTRETTNLERICIFIGADNQRFANLSLTAPAAVQWHIYDGSSDSLSSKNPLTAQFIRRRYFHIEKCKDAQTLGLIVATLSAEGYLDVVTRLQTMAKGRGIKTQLISVGRINPAKLANFLEIDCFVLIGCPFNNMYDSKEYYKPIVSVFEAEMALNPAWHMRYPEAYVTDFKQLLPEGRSFLPFDAADIPENDVSLVSGRLRGAVNDSLETGGDPASLALATQAKMALMTTDTGLSFEDRTWQGLDPALGQTEPAKLQQGLSGIPINYSHQ
Protein: Epsin-2 (EPS-15-interacting protein 2) (Intersectin-EH-binding protein 2) (Ibp2) (Q8CHU3)
Organism: Mus musculus (Mouse)
Function: Plays a role in the formation of clathrin-coated invaginations and endocytosis.
Subcellular location: Cytoplasm {ECO:0000250}. Note=In punctate structures throughout the cell and particularly concentrated in the region of the Golgi complex. {ECO:0000250}.
Interaction partners:
- Clathrin heavy chain 1
- Epidermal growth factor receptor substrate 15
- Epidermal growth factor receptor substrate 15-like 1
- AP-2 complex subunit beta
- Intersectin-1
- Synaptojanin-1
- Clathrin light chain A
- AP-2 complex subunit alpha-1
- Clathrin light chain B
- Clathrin coat assembly protein AP180
Sequence:
MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKVERVQALKTKERMAQVATGVGSNQITFGRGSSQPNLSTSYSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQSSESVQTARGSKEERLRRGDDLRLQMALEESRRDTVKVPKKKEAKACCKPGSHSQQTTLLDLMDALPSSGPVTQKTEPWSAGASANQTNPWGGTVAPSNITDPWPSFGTKPAASVDPWGVPTTASTQSVPKNSDPWAASQQPASNAGKTTDAWGAAKPSSASGSFELFSNFNGTVKDDFSEFDNLRTSKKPAESGASVPPQDSRTTSPDLFESQSLTSASSKPSSARKTPESFLGPNAALVNLDSLVTKPAPPAQSLNPFLAPGAAAPAPVNPFQVNQPQPLTLNQLRGSPVLGSSASFGSGPGVETVAPMTSVAPHSSVGASGSSLTPLGPTAMNMVGSVGIPPSAAQSTGTTNPFLL
Protein: Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) (P19643)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.
Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Interaction partners:
- Catechol O-methyltransferase
- Transmembrane O-methyltransferase homolog
- Aromatic-L-amino-acid decarboxylase
- Aldehyde dehydrogenase
- Amine oxidase [copper-containing] 3
- Dopamine beta-hydroxylase
- Amine oxidase
- Amine oxidase
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Diamine oxidase [copper-containing]
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
Protein: Protein RER1 (Retention of ER proteins 1) (P25560)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Required for correct localization of SEC12, SEC71 and SEC63 in the endoplasmic reticulum.
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein.
Interaction partners:
- Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
- ER degradation-enhancing alpha-mannosidase-like protein 1
- Guanine nucleotide-exchange factor SEC12
- Putative endoplasmic reticulum mannosidase MNL2
- ER lumen protein-retaining receptor
- Calnexin homolog
- ER-derived vesicles protein ERV29
- Translocation protein SEC66
- Coatomer subunit beta'
- Alpha-1,2-mannosyltransferase ALG9
Sequence:
MDYDSSDTMNGGSSNPLITKMNTMKLLYQHYLDKVTPHAKERWAVLGGLLCLFMVRITMAEGWYVICYGLGLFLLNQFLAFLTPKFDMSLQQDEENNELEAGEKSEEFRPFIRRLPEFKFWYNSIRATVISLLLSLFSIFDIPVFWPILLMYFILLFFLTMRRQIQHMIKYRYIPLDIGKKKYSHSSN
Protein: Uncharacterized protein (Q57XM5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLQKAGRHGGYATQFWTKRRTAYRTRHEALTAHSVKSIQRRLVLPLEAHDWSRALEVLRARYALLGRTTLDYQRVIRGIAADNVSPFRIQTGVKLLNELRDEVYAGDVKADGVWVTLLWAYVHLGRPLEGYECLLQAKRRVKMSALTWHHMGETLIPLLAEFGMLAEARYVFENFMQVGGSLQEKERMSHIIAEAAARSGSWTEAIQAICRSTGDVAVEKVEPIVTKPTNPTLASLFVAEAPGSTPGVGRVRTPIDSGSLQNKRLTTEAVRSMMYSMARDGQWTLALGCLHELWGRQMPCAQQDSHTPRCASISVDGVAPASVSSTSGDVALQPLIMTSSEMQQLLNALGDQKRWKEAVRLFRDCYLSGCTHPLVRTSHPLKPLTLNLLFSAFPRETRELTLTNSGEEPELSHLDHMDSKRQQISGVEKVQITLQLDVVCHPDQVVVLLDQLLLERDDIVITDCMMGTVGPALVQLGQWDRALHLLRQVPELFPTKEKHLRQHEQLESAETKRRIRQHLVALLFYLYSAVSLEARYYTILHFPHVFPAEMFSSMPPPKELAASLRELQQQRIEKCEKKEALRHFASRRRSRTVQRTEQMDAELRERLTLLHSKRANAFCVEDDPERDPRPIPKGLHDTASGWNFYGRGGEMVFMNHRRTAHPFSMHPKVMRSLADPYRGWGLKQNSCWAHRERVKKWNGNSAV
Protein: GPI mannosyltransferase 1 (EC 2.4.1.-) (GPI mannosyltransferase I) (F4K8F7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365064}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365064}.
Interaction partners:
Sequence:
MSRESENTDDEPSKWMKFRSLLVFSMLLRVFLIVYGEWQDAHMEVRYTDVDYIVFSDAASLMASGESPYKRTTYRYSPLLALLLTPNSFFHRSWGKFLFSASASQCVDDLFLCRFGIYFHVSDLLVGWFIHKILKQRKVPEKICTYSVMVWLFNPFTFTIGTRGNCEPIVCAMILWIILCLMQGNLLQAAFWYGLVVHFRVYPIIYALPIILVLDTQVFRSGQKPALLYWNTGQAKTPASNMERKTFLFNLLTTLKSLFSRERIMFALISGGVFLACNAVSFYFYGQEFLHEALLYHLTRTDPRHNFSIYFYHIYLHYERQFSAVEKLISFLPQFTVQFALVFCFSQDLVFCIFLQTVAFVTFNKVITAQYFVWFYCLLPLILPWSHMKLKWEGLLCIIMWIGAQTHWLLWGYMLEFKGVNVFLPLWIASLLFLAANTFVLVRIIQRHRFSPLFRRYESSSSSNNVTKED
Protein: Granzyme A (EC 3.4.21.78) (CTL tryptase) (Cytotoxic T-lymphocyte proteinase 1) (Fragmentin-1) (Granzyme-1) (Hanukkah factor) (H factor) (HF) (P12544)
Organism: Homo sapiens (Human)
Function: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Subcellular location: [Isoform alpha]: Secreted {ECO:0000269|PubMed:3257574}. Cytoplasmic granule {ECO:0000269|PubMed:3257574}. Note=Delivered into the target cell by perforin. {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:32299851}.
Interaction partners:
- Perforin-1
- Granulysin
- Granzyme K
- T-cell surface glycoprotein CD8 alpha chain
- Killer cell lectin-like receptor subfamily B member 1
- T-cell surface glycoprotein CD3 delta chain
- Protein NKG7
- T-cell surface antigen CD2
- Protein SET
- Natural killer cells antigen CD94
Sequence:
MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLMEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWIIMTIKGAV
Protein: LexA repressor (EC 3.4.21.88) (Q87KN2)
Organism: Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Interaction partners:
Sequence:
MKPLTPRQQQVFDLIKSKIDDTGMPPTRAEIARELGFRSANAAEEHLKALARKQAIEIIPGASRGIRILLEDAANDEQGLPLIGQVAAGEPILAQEHVEAHYQVDPAMFKPQADFLLRVNGESMKDIGIMDGDLLAVHKTQDVRDGQVVVARVDDDVTVKRLERKGSTVLLHAENEEFAPIQVDLTSQHLTIEGLAVGIIRNTDWM
Protein: Phospholipase ABHD3 (EC 3.1.1.32) (EC 3.1.1.4) (Abhydrolase domain-containing protein 3) (Lung alpha/beta hydrolase 3) (MmLABH3) (Q91ZH7)
Organism: Mus musculus (Mouse)
Function: Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Phosphatidylserine lipase ABHD16A
Sequence:
MQRLAMDLRVLSRELALYLEHQVRVGFFGSGVGLSLILGFSVAYACYYLSSIAKKPQLVIGGESFSRFLQDHCPVVTETYYPTVWCWESRGQTLLRPFITSKPPVQYRNELIKTADGGQISLDWFDNNNSAYYVDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGESLLTPRTYCCANTEDLEAVVHHVHSLYPGAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLERPLNWLLFNYYLTTCLQSSVKKHRHMFVEQIDMDQVMKAKSIREFDKRFTAVMFGYRTLDDYYTDASPNRRLKSVGIPVLCLNATDDVFSPSHAIPIETAKQNPNVALVLTAYGGHIGFLEGIWPRQCTYMDRVFKQFVQAMVEHGHELSNM
Protein: CO(2)-response secreted protease (Subtilisin-like serine protease) (AtSBT5.2) (Tripeptidyl-peptidase II) (EC 3.4.14.10) (Q9LNU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates CO(2)-controlled stomatal development by cleaving peptide EPF2 (AC Q8LC53). Not active on peptides EPF1 (AC Q8S8I4) or stomagen (AC Q9SV72).
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:25043023}.
Interaction partners:
- Protein EPIDERMAL PATTERNING FACTOR 2
- GDSL-like Lipase/Acylhydrolase superfamily protein
- GDSL-like Lipase/Acylhydrolase family protein
- EPIDERMAL PATTERNING FACTOR-like protein 9
- Protein EPIDERMAL PATTERNING FACTOR 1
- Beta carbonic anhydrase 4
- AT1G10660 protein
- Probable pectinesterase/pectinesterase inhibitor 17
Sequence:
MKGITFFTPFLSFLYLLCILFMTETEAGSRNGDGVYIVYMGSASSAANANRAQILINTMFKRRANDLLHTYKHGFSGFAARLTAEEAKVIAKKPGVVSVFPDPHFQLHTTHSWDFLKYQTSVKVDSGPPSSASDGSYDSIVGILDTGIWPESESFNDKDMGPIPSRWKGTCMEAKDFKSSNCNRKIIGARYYKNPDDDSEYYTTRDVIGHGSHVSSTIAGSAVENASYYGVASGTAKGGSQNARIAMYKVCNPGGCTGSSILAAFDDAIADGVDVLSLSLGAPAYARIDLNTDPIAIGAFHAVEQGILVICSAGNDGPDGGTVTNTAPWIMTVAANTIDRDFESDVVLGGNKVIKGEGIHFSNVSKSPVYPLIHGKSAKSADASEGSARACDSDSLDQEKVKGKIVLCENVGGSYYASSARDEVKSKGGTGCVFVDDRTRAVASAYGSFPTTVIDSKEAAEIFSYLNSTKDPVATILPTATVEKFTPAPAVAYFSSRGPSSLTRSILKPDITAPGVSILAAWTGNDSSISLEGKPASQYNVISGTSMAAPHVSAVASLIKSQHPTWGPSAIRSAIMTTATQTNNDKGLITTETGATATPYDSGAGELSSTASMQPGLVYETTETDYLNFLCYYGYNVTTIKAMSKAFPENFTCPADSNLDLISTINYPSIGISGFKGNGSKTVTRTVTNVGEDGEAVYTVSVETPPGFNIQVTPEKLQFTKDGEKLTYQVIVSATASLKQDVFGALTWSNAKYKVRSPIVISSESSRTN
Protein: La-related protein 6B (AtLARP6b) (VirF-interacting protein FIP1) (O80567)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- At4g13270 hydroxyproline-rich glycoprotein family)
- Cleavage stimulation factor subunit 77
- Serine-threonine kinase receptor-associated protein
- Serine-threonine kinase receptor-associated protein
- Pre-mRNA cleavage factor Im 25 kDa subunit 1
- 30-kDa cleavage and polyadenylation specificity factor 30
- Polyadenylation and cleavage factor homolog 4
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage stimulating factor 64
- Nuclear poly
Sequence:
MADQQTLDSSTPPPTQSDDLSHSHSTSSTTSASSSSDPSLLRSLSLSRLNAGAPEFVPGRTTPPLPQPPRMIIPPPPPHGMLHMYHHQPPFNTPVLGPVPIQPHLVPVQNHHPHHRFHQHHHHNRHQNQQYVPVRNHGEYQQRGGVGGEQEPDLVSKKNDRRDHSKRESKNDQVTETGASVSIDSKTGLPEDSIQKIVNQVEYYFSDLNLATTDHLMRFICKDPEGYVPIHVVASFKKIKAVINNNSQLAAVLQNSAKLFVSEDGKKVRRISPITESAIEELQSRIIVAENLPEDHCYQNLMKIFSTVGSVKNIRTCQPQNNGSGAPPAARSAAKSDGTLFSNKVHAFVEYEIVELAERAVTELSEAGNWRSGLKVRLMLKHQTKEPKQGQGRGRKGHDADVEHEEDDATTSEQQPIEKQSDDCSGEWDTHMQEQPIGEDQGNEKAAGQRKGRNRGRGKGRGRGQPHQNQNQNNNHSHNQNHNHNGRGNHHHHHHHQVGTQPSNNPMNNMEQPGMGKQQPPGPRMPDGTRGFSMGRGKPVMVQAE
Protein: 34 kDa extracellular nuclease (EC 3.-.-.-) (P83222)
Organism: Streptomyces antibioticus
Function: Involved in DNA degradation in the substrate mycelium. Cuts DNA nonspecifically. Possesses endonucleolytic activity.
Subcellular location: Secreted {ECO:0000269|PubMed:10400660}.
Interaction partners:
Sequence:
GTLIGQDYK
Protein: Transcription factor BIM2 (BES1-interacting Myc-like protein 2) (Basic helix-loop-helix protein 102) (AtbHLH102) (bHLH 102) (Transcription factor EN 125) (bHLH transcription factor bHLH102) (Q9CAA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Positive brassinosteroid-signaling protein.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein BRASSINAZOLE-RESISTANT 2
- Transcription factor bHLH51
- Proline-, glutamic acid/leucine-rich protein
- AT-rich interactive domain-containing protein 4
- Transcription factor PAR1
Sequence:
MRTGKGNQEEEDYGEEDFNSKREGPSSNTTVHSNRDSKENDKASAIRSKHSVTEQRRRSKINERFQILRELIPNSEQKRDTASFLLEVIDYVQYLQEKVQKYEGSYPGWSQEPTKLTPWRNNHWRVQSLGNHPVAINNGSGPGIPFPGKFEDNTVTSTPAIIAEPQIPIESDKARAITGISIESQPELDDKGLPPLQPILPMVQGEQANECPATSDGLGQSNDLVIEGGTISISSAYSHELLSSLTQALQNAGIDLSQAKLSVQIDLGKRANQGLTHEEPSSKNPLSYDTQGRDSSVEEESEHSHKRMKTL
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (A0A0B4J203)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Pre-mRNA 3'-end-processing factor FIP1
- Cleavage and polyadenylation specificity factor subunit 4
- Cleavage stimulation factor subunit 3
Sequence:
MSAGEVERLVSELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDENEVERPEEENASANPPSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
Protein: tRNA1(Val) (adenine(37)-N6)-methyltransferase (EC 2.1.1.223) (tRNA m6A37 methyltransferase) (P31825)
Organism: Escherichia coli (strain K12)
Function: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- tRNA
- tRNA sulfurtransferase
- Carboxy-S-adenosyl-L-methionine synthase
- tRNA
- tRNA
- Ribosomal RNA large subunit methyltransferase K/L
- Ribosomal RNA large subunit methyltransferase J
- Ribosomal RNA large subunit methyltransferase M
- Ribosomal RNA small subunit methyltransferase I
Sequence:
MSQSTSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTDDSVMIDAVELESEAAAQAQENINQSPWAERINVHTADIQQWITQQTVRFDLIISNPPYYQQGVECSTPQREQARYTTTLDHPSLLTCAAECITEEGFFCVVLPEQIGNGFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQNYSEAYTALTQAFYLFM
Protein: Protein BYPASS1-LIKE (Q9M9U5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:35249253}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:31297122}. Nucleus {ECO:0000269|PubMed:31297122}. Vesicle {ECO:0000269|PubMed:35249253}.
Interaction partners:
- Transmembrane Fragile-X-F-associated protein
- Transmembrane Fragile-X-F-associated protein
- AT5g12010/F14F18_180
- At4g27652
- Nuclease
- Protein BPS1, chloroplastic
- 14-3-3-like protein GF14 psi
- BRAP2 RING ZnF UBP domain-containing protein 1
- 14-3-3-like protein G-BOX factor 14 kappa
- ATP phosphoribosyltransferase 1, chloroplastic
Sequence:
MPATDFQGSFGRSLLSLRRDQVDSSTVVSGSSSHHEPSTMEVELDSFQRQVAEKFIDLNASSNDLLSLEWIGKLLDSFLCCQEEFRAIVFNHRSQISKSPMDRLISDYFERSIKALDVCNAIRDGIEQIRQWEKLADIVISALDSHRPIGEGQLRRAKKALIDLAIGMLDEKDHPSGTNLAHRNRSFGRVKDSHHRSIGHFRSLSWSVSRSWSASKQLQALASNLATPRPNDVVASNGLAVPVYTMTSVLLFVMWVLVAAIPCQDRGLQVNFFVPRHFQWAAPVMSLHDKIVEESKRRDRKNCCGLLKEIDRIEKSSRLMNELIDSIHFPLNDDKEVEVKQRVDELVQVREALRNGLDPFERKVREVFHRIVRSRTESLDSL
Protein: Uncharacterized protein (Q381J2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSRPDKRRHRDCVVGTTKDESVRLYAFANTRPGYQVVFSPEQPLIVLKTRKSADKPRQHPCMQWSPLASLLFVQLPNTTHAMYVADTTGLPDSMEREEQVSTTVGPIVKRLANVVAKLNPHNGTMVAAGVSGVLAFKYIFMGEKTLGHTDRLVQRLLLVCPPSIHPFLALFQVMGKRVPERGYPKPEIVVVLSDVSAVNGWNEFLTDFAATSALESWSVSSNVEPSLFAAILREAGISADGTKVALETRHSAPRVYRIDFVLSAVTKRTEQQVTLSPLSSSGCGEEDMGSSPLESDDGEECEDEEEYECGDHERGLGKSEFPPVCRGVGTSEEVFGLMSLPNCKRSTCVVVEGRIMDAAATTLGTTQGRVYVTGMHEVLKCSSSGTSSVHKSIKGVAVRLRSFVKRDEQGRTSLQVTSAVFLTKNQERRSMTVCSMAQVPAYNVSEVAHAYGALLVRGRKCVLVRSLDEEYEGVRLPYLLHTSSEESSMECAERALCEHCDISPDNFYLPSYIPPTCVYEKDADTGITTSRMMYVALAVTPPAEGAGDAVEDEEDFNEPYDWFGYTRALRMLQSCADRKIVQQLQCAVRSAYDVGLYIPLKGLGVFGDDVLGVAGRRTSEVEPASGMRRPLEGLELLVVCSPGDTSGQSMQVAREHLTECVLRVGNETPRCEILQGARETMQAGKTTLVLCLQCDVDVNVFSEEQLTYWSEKGARPRLVTLLFSGVSEMILQGADDGADSASAFIYSIMLSDVLVTAEEDQQKFTSEMWGLLQLAHELNGELMLCAGIVSRRPIETPPIGKEGDGGDQTSYDESSLHEITVTCTGRPVEPSRLARLLEVAGLDECYRHAVVLWVQGEVWIASRPKSRGLLALDISSRCLTLEEGEPWEDDEGDDRAGKGEDKRQNVITVYVWATAAGRDAVRGTINTIWEPVLCTASPLPRGISEGAKVGEVDDGLPPWE
Protein: Anaphase-promoting complex subunit MND2 (Meiotic nuclear division protein 2) (P40577)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
Interaction partners:
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit CDC27
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit CDC16
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit CDC23
- Anaphase-promoting complex subunit SWM1
- Anaphase-promoting complex subunit CDC26
Sequence:
MARALRDISLFNDIRKDQNSAGAKHERYNMRDLRSKKNQHVNGIDDYEDDSLDRFIRRKKSRVVKYIPSLSAYNVFNEFPYYPTSASQLLDGKLDEFLMLSEQYKSRLPKIRKLGWNRFKPIGINKTMYELEMLRSRARAQNAEGNNEEDFRQHDSREEDPRNNGSIGRVILPHILQENEEYDTGEGVTGLHSMPNDSMAILANNSANNSQNEEVSEEDEISYDYDAEFDHVVDEDDNEEGEVPGEGVEGIEVQRERIVPDDLLMRPTSLSRSLQQFVEEAHHLDRNPYDIDSDNDGEDSKVELDMNPDFEDDVGREHDYNSEYSQEPTSYGGITPDLASNWRNWTRERITSLDELMERRARQQRGQD
Protein: Zinc finger protein ZFP2 (Zfp-2) (Zinc finger protein 751) (Q6ZN57)
Organism: Homo sapiens (Human)
Function: Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MEREGIWHSTLGETWEPNNWLEGQQDSHLSQVGVTHKETFTEMRVCGGNEFERCSSQDSILDTQQSIPMVKRPHNCNSHGEDATQNSELIKTQRMFVGKKIYECNQCSKTFSQSSSLLKHQRIHTGEKPYKCNVCGKHFIERSSLTVHQRIHTGEKPYKCNECGKAFSQSMNLTVHQRTHTGEKPYQCKECGKAFHKNSSLIQHERIHTGEKPYKCNECGKAFTQSMNLTVHQRTHTGEKPYECNECGKAFSQSMHLIVHQRSHTGEKPYECSQCGKAFSKSSTLTLHQRNHTGEKPYKCNKCGKSFSQSTYLIEHQRLHSGVKPFECNECGKAFSKNSSLTQHRRIHTGEKPYECMVCGKHFTGRSSLTVHQVIHTGEKPYECNECGKAFSQSAYLIEHQRIHTGEKPYECDQCGKAFIKNSSLTVHQRTHTGEKPYQCNECGKAFSRSTNLTRHQRTHT
Protein: SLC11A2 (Q0GMA8)
Organism: Gallus gallus (Chicken)
Subcellular location: Late endosome membrane {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004107}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004155}.
Interaction partners:
Sequence:
MGPPYSDLRESDEDRPAEAVGSVSGSRNALQPLPGEDDEEPFTTYFDSKIPIPDDETHSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATVIGLLLQRLAARLGVVTGLHLAEVCHRQYRTVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSVGKIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVRPDQKQLLRGLFVPECRGCGTPQLEQAVGIVGAVIMPHNMYLHSALVKSRQVNRSNPREVRDANKYFFAESCIALFVSFIINVFVVSVFAEAFYGKTNADVHEVCANASSAHAALFPSDNATLEVDIYKGGAVLGCYFGPAALYIWAIGILAAGQSSTMTGTYSGQFVMEGFLNLRWSRFARVLLTRSIAITPTLFVAIFQDVEHLTGMNDFLNVLMSLQLPFALIPVLTFTSLPSVMNDFANGLFWKIGGGAVILLVCSINMYFVVAYVMALNHVGLYVVAAVIGLYVGAAILSVIYLAFVAYLTWLCLIALGASSL
Protein: Krueppel-like factor 9 (Basic transcription element-binding protein 1) (BTE-binding protein 1) (GC-box-binding protein 1) (Transcription factor BTEB1) (O35739)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13886}.
Interaction partners:
- Progesterone receptor
- Paired amphipathic helix protein Sin3a
Sequence:
MSAAAYMDFVAAQCLVSISNRAAVPEHGGAPEAERLRLPEREVTKEHGDPGDTWKDYCTLVTIAKSLLDLNKYRPIQTPSVCSDSLESPDEDIGSDSDVTTESGSSPSHSPEERQDSGSAPSPLSLLHSGVASKGKHASEKRHKCPYSGCGKVYGKSSHLKAHYRVHTGERPFPCTWPDCLKKFSRSDELTRHYRTHTGEKQFRCPLCEKRFMRSDHLTKHARRHTVFHPSMIKRSKKALACPL
Protein: Protein COS5 (P47187)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Protein SNA3
Sequence:
MKENELKNEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIYKSLAFPIWMLLWLPLSVWWKLSNNCIYPLIVSLLVLFLGPIFVLVICGLSRKRSLSKQLIQFCKEVTENTPSSDPHDWEVVAANLNSYLYENKAWNTRYFFFNAMGCQEAFRTTLLEPFSLKKDEAAKVKSFKDSVPYIEEALGVYFREVEKQWKLFNTEKSWSPVGLEDVQLPKDIHRSKLTWFLKRIFTIYSLPLWLAFLNCICVSQHFCLAFRILCPGLFFLMMVWLFQNMRTTALLVKMEHKMQFLLTIINEQESGANGWDEIARKMNRYLFEKKAWKNEEFFFEGIDCEWFFSHFFYRLLSAKKSMWLLPLNVELWPYIKEAQLSRNEESLMKK