wanglab/gogpt-training-data huggingface dataset:
Protein: 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (cAMP-specific phosphodiesterase 4D) (Q01063)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Subcellular location: Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Apical cell membrane {ECO:0000250}. Note=Colocalized with SHANK2 to the apical membrane of colonic crypt cells (By similarity). Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome. {ECO:0000250}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Deoxycytidine kinase
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenine phosphoribosyltransferase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- GTP:AMP phosphotransferase AK3, mitochondrial
- Adenylosuccinate lyase
- A-kinase anchor protein 7 isoform gamma
Sequence:
MERDTCDVLSRSKSASEETLHSCNEEEDPFRGMEPYLVRRLSSRSIQLPPLAFRQLEQADLRSESENIPRPTSLPLKILPLIAVTSADSSGFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQEEGRQGQTEKFQFELTLEEDCESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPETCVPDDCCPDT
Protein: OBP3-responsive protein 4 (ORG4) (Q8VY85)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable plastid-lipid-associated protein 14, chloroplastic
- Extensin-1
- Dof zinc finger protein DOF3.6
Sequence:
MEPPSSRPEEPPSWEDLYKINLMPSELFLKFRKELQGLRVGVNLELYNEPTNDYHAKLVLKPLCPERKWKFIYEPLHQEVRVLSKKIPVTRFLNLQVGVGHNFQMNAIGWKWKLTSCLGGDGVSRIRNKTTLGLSPGIDFRFGWRADFVLPEVTGALGTEEPLFNMSSGRLEASLDRVEAIVTHSDYL
Protein: Uncharacterized protein (Q57WZ7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFAPFFRSLKSNAIAQRGLFVAKTSLRQYRCRLFCSPSAVLLCSFSRDMPLSISQLRTRLRSQLQDGCPRMQSIDTEGQLTLTLARSRRPAEQEEALERAESLWRELEDSASPLPLTSITGLRVSLCTSMRRCALVARKQELAESWTRRFANLRNLQPMDFTTGANVAAGRVRGWQHGRPAEETDQEEMSGGVVDDDGAGAEGAGRKSGNKETPLQKYRQEVMMDHPMMQLAFKRGVHTPGPRYTGD
Protein: Terf2 protein (B1H237)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAGAGTAGPASGPGVVRDPMASQPRKRPGGEGARRSNTMAGGGGSSDNGGRAANRRASRSGGRARRGRHEPGLGGAAERGAGEARLEEAVNRWVLKFYFHEALRAFRSSRYRDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTDSMVESSRRLVKEAAVIICIKNKEFEKASKILKKYMSKDPTTQKVRTDLLNIIREKNLAHPVIQNFSYEIFQQKMLRFLESHLDDTEPYLLTMAKKALRSESAASSTMKEEKHTEPVEKPLREPPRQPRNPPTTIGLRTVKAAFKALSTAQDSEAAFAKLDQKDLVLPNLASPSSPTHKNKRPRKDENESSAPAEGEGGSERQPRNNRMTISRLVLEEDSQSSEPSPDLNSSRQALSASPSKPRALNQPHTGEKNPKYEDLLCSSLGAGWWSWWAWFYFHE
Protein: Beta-lactamase-related domain-containing protein (Q2TWX4)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
Sequence:
MQNLVPMTTSTLMPICSITKQMVCMILKDLERNPTPEMVKRGNVSRQFSDALHQMLHPDLTTNTALELEHLCHNQSGIRDYWAMSMFWGAHPDGVFRLEEDAKKALERTKSLHFEPGTQYSYCNLNFYILARLIENVSGQTLSALLTERLFLPAQMKTARLCADNANLPPPCVGYEGTESSGFIPAINRMQWSGDAGVVASLKDMIAYEHYLLTCWDEEKSVYRAIAQQQSFKDGTVAQYGYGLKHVTIRGMATIGHGGALRGFRLHRIQAPSEKVAVVVMLNHQADAEEAAQDIMKSVLDIFPSHVPQSDPVNPSPDWFGTFYDPDAQLVVEIRHGGQGHVIVSYAGSDETLICVGENEAGSNNTVGIIDGGIPKLRRLVDNRVLDVKRVATGYPPHKDDYLGEYYCAEIDSTFRCSGAGGMLYGHFEGYLGQGPPHLMRYIGEDIWMLSCPRGLDAPAPGNWTVVFQRADHGDITSVTIGCWLARKVVFVKR
Protein: 3-hydroxybenzoate synthase (EC 4.1.3.45) (O30478)
Organism: Streptomyces hygroscopicus
Function: Involved in the biosynthesis of BC325, a rapamycin analog containing a 3-hydroxybenzoate starter unit. Catalyzes the hydrolysis of chorismate via an intramolecular mechanism to yield 3-hydroxybenzoate (3HBA).
Interaction partners:
Sequence:
MNPSSLVLNGLTSYFENGRARVVPPVGRNILGVVNYASVCEYPTLDHGYPELEINMVAPTAEPFAEVWVTDAESEHGERDGITYAHDGEYFFCAGRVPPTGRYTEATRAAYVTMFELLEEFGYSSVFRMWNFIGDINRDNAEGMEVYRDFCRGRAEAFEQCRLEFDQFPAATGIGSRGGGIAFYLLACRSGGHVHIENPRQVPAYHYPKRYGPRAPRFARATYLPSRAADGVGGQVFVSGTASVLGHETAHEGDLVKQCRLALENIELVISGGNLAAHGISAGHGLTALRNIKVYVRRSEDVPAVREICREAFSPDADIVYLTVDVCRSDLLVEIEGVVM
Protein: Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (E9Q735)
Organism: Mus musculus (Mouse)
Function: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11435423}.
Interaction partners:
- Ubiquitin recognition factor in ER-associated degradation protein 1
- Ubiquitin thioesterase OTU1
- Transitional endoplasmic reticulum ATPase
- UV excision repair protein RAD23 homolog B
- UV excision repair protein RAD23 homolog A
- Nuclear protein localization protein 4 homolog
- Fanconi anemia core complex-associated protein 100
- E3 ubiquitin-protein ligase TRIP12
- ATPase family gene 2 protein homolog A
Sequence:
MTDQENNNNISSNPFAALFGSLADAKQFAAIQKEQLKQQSDELPASPDDSDNSVSESLDEFDYSVSEISRSFRTHQEMCEQLNINHMIQRIFLITLDNSDPSLKSGNGIPSRCVYLEEMAVELEDQDWLDMSNVEQAIFARLLLQDPGNHLISMTSSTTLNLSADRDAGERHIFCYLYSCFQRAKEEITKVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGAHFEDVTEFLEEVIEALLLDEEVRTFPEVMIPVFDILLSRIKDLELCQILLYAYLDILLYFTRQKDMAKVFLEYIQPKDPSNGQMYQKTLLGVILNISCLLKTPGVVENHGFFLNPSRSSPQEIKVQEANIHQFMAQFHEKIYQMLKNLLQLSPETKHCILFWLGNCLHANAGRTKIWANQMPEIFFQMYASDAFFLNLGAALLKLCQPFCKPRSSRLLTFNPTYCVLKDLNDEERKIKSVHMRGLDKETCLIPAVQEPTFPQSYNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQVAWRDAQQSSSPAADNLREQFERLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLAIGNEGSQPIELSFPLPDGYSSLAYVPEFFADNLGDFLIFLRRFAEDILETSADSLEHVLHFITIFTGSIERMKNPHLRAKLAEVLEAVMPHLDQTPSPLVSSVFHRKRVFCNFPYAPQLAEALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWGTDCYRESIKYLSKIKIQQIEKDRGEWESLTPEARREKEAGLQMFGQLARFHNIMSNETIGTLSFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIVAFSNLAERIKSLADLQQQEEETYADACDEFLDPIMSTLMSDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQQKEQPE
Protein: LD26355p (Q7YU13)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLSRKRRASSISSRQDEDPLQLDDSTPEQSPVQQTTTQSARKKRRLDPTELCQQLYDSIRNIKKEDGSMLCDTFIRVPKRRQEPSYYDVVVNPIDLLKVQQKLKTDSYDDLDDLMADLELLIGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEPRARRMSRQVRRMTSSTEPGGDGATDDEYNQYEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELEMGKGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGEGPMWALFDHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLTEGKKSQQKYSKVGRKLKTAVITERLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACLERARKLSRTDSDIFQDSIELQTYFIRKRDELCKDTLSSSALNFSLERLMADVELCRQQKMQQEEQDQEQDKEKDEFNAAKGESMTINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPEKDVYVCESRYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQETLVEKEKPNVSCDPPPNAEVGSTYYQQYNTICSGAIKTGDFVYVATQTGKQSVAQVQQIWEQNGKSYFKGSWLLPPSETTPGLGKQFYRQELLLSTVEEVSPVVGIVGRCAVLEYSEFISSRPTEISESDVYICESVYDELKKALRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKPSKDFKNELNELGMLEDSMDGDTPSLSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKKCLTGYILYSSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSVKQSWEDRASRQNEETAALRRELDDVQNSASPSSQVSQDVFGQVLTFECQWDKCDFQFEELSDCTEHCMSDSTGHIQRHPQAGVETEYVCLWRNCPRVKKSVQAFPNVLRLIKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLATTVPIPPSLAQSPRAPSNLEAVQLQQQQHPQQNMHQLQQQQTIVLGPPPEPLFVTVPPRTTRVIHSEAYIKYIESLQTGSHLNVVTCNNNWRRALTHITPAQVVAKTALPEKWIGPNLRDQGNVVQALCHLRNFMVDDILQIRRSCN
Protein: Eukaryotic translation initiation factor 4E-2 (eIF4E-2) (eIF-4F 25 kDa subunit) (eIF-4F p26 subunit) (mRNA cap-binding protein) (A0A3Q7FGP1)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity). Key component of recessive resistance to potyviruses.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:C6ZJZ3}. Cytoplasm {ECO:0000250|UniProtKB:C6ZJZ3}.
Interaction partners:
- Eukaryotic translation initiation factor 4G
- MI domain-containing protein
- MI domain-containing protein
- Eukaryotic translation initiation factor 4G
- MIF4G domain-containing protein
- CYRIA/CYRIB Rac1 binding domain-containing protein
- Polyadenylate-binding protein
- W2 domain-containing protein
- RRM domain-containing protein
- PABC domain-containing protein
Sequence:
MADELNKAALEEYKSSSVEDRGEEGEIVGESDDTASSLGKQITMKHPLEHSWTFWFDNPSGKSKQAAWGSSIRPIYTFSTAEDFWSVYNNIHHPSKLAVGADFHCFKNKIEPKWEDPVCANGGKWTMNFSRGKSDTCWLYTLLALIGEQFDYGDEICGAVINVRVRQEKIALWTRNAANETAQVSIGKQWKEFLDYNDTIGFIFHDDAKKLDRAAKNRYSV
Protein: Serine/threonine-protein phosphatase PP1 isozyme 9 (EC 3.1.3.16) (Type one protein phosphatase 9) (Q9M9W3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine-protein phosphatase that possesses phosphatase activity toward para-nitrophenyl phosphate (pNPP) in vitro.
Subcellular location: Nucleus {ECO:0000269|PubMed:19329567}. Cytoplasm {ECO:0000269|PubMed:19329567}.
Interaction partners:
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Flowering time control protein FY
- Protein ANTHESIS POMOTING FACTOR 1
- Transducin/WD40 repeat-like superfamily protein
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 3-I
- Protein phosphatase 1 regulatory subunit INH3
- Putative 26S proteasome non-ATPase regulatory subunit 8 homolog B
- 30-kDa cleavage and polyadenylation specificity factor 30
- Cleavage and polyadenylation specificity factor subunit 1
Sequence:
MMTSMEGMMEMGVLDDIIRRLLEGKGGKQVQLSEVEIRQLCVNARQIFLSQPNLLELHAPIRICGDIHGQYQDLLRLFEYGGYPPSANYLFLGDYVDRGKQSLETICLLLAYKIRYPSKIFLLRGNHEDAKINRIYGFYDECKRRFNVRLWKIFTDCFNCLPVAALIDEKILCMHGGLSPELENLGQIREIQRPTEIPDNGLLCDLLWSDPDQKNEGWTDSDRGISCTFGADVVADFLDKNDLDLICRGHQVVEDGYEFFAKRRLVTIFSAPNYGGEFDNAGALLSVDQSLVCSFEILKPAPASSTNPLKKVPKMGKS
Protein: Chromodomain helicase DNA binding protein 6 (A0A075B6P4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKMKIQKKEKQLSNLKVLNHSPMSDASVNFDYKSPSPFDCSTDQEEKIEDVASHCLPQKDLYTAEEEAATLFPRKMTSHNGMEDSGGGGTGVKKKRKKKEPGDQEGAAKGSKDREPKPKRKREPKEPKEPRKAKEPKKAKEHKEPKQKD
Protein: Uncharacterized protein, isoform C (EC 3.4.21.-) (B7Z091)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO08953p1
- AT20289p
- Seminal fluid protein 24F
- Seminal metalloprotease 1
- RT03039p
- Peptidase S1 domain-containing protein
- Uncharacterized protein, isoform A
Sequence:
MQGLLLYCLLTAPLASIEVLAQDLNQTIDVNKLAKIVQRPGFQTRVVGGDVTTNAQLGGYLIALRYEMNFVCGGTLLHDLIVLTAAHCFLGRVKISDWLAVGGASKLNDRGIQRQVKEVIKSAEFREDDMNMDVAILRLKKPMKGKSLGQLILCKKQLMPGTELRVSGWGLTENSEFGPQKLLRTVTVPVVDKKKCRASYLPTDWESHKHFDLFLKVHLTDSMFCAGVLGKKDACTFDSGGPLVYKNQVCGIVSFGIGCASKRYYGVYTDIMYVKPFIEQSIKVLLAKR
Protein: Protein CLN8 (Q9QUK3)
Organism: Mus musculus (Mouse)
Function: Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UBY8}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q9UBY8}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:19941651}.
Interaction partners:
- Ceroid-lipofuscinosis, neuronal 6
- Bis
- Palmitoyl-protein thioesterase 1
- Battenin
- Major facilitator superfamily domain-containing protein 8
- Tripeptidyl-peptidase 1
Sequence:
MTPVSSHGLAESIFDLDYASWKIRSTLAVAGFVFYLGVFVVCHQLSSSLNATYRSLAAKEKVFWNLAATRAVFGVQSTTAGLWALLGDPVLYADKALGQQNWCWFHITTATGFFFFENVAVHLSNLFFRTFDLFLVVHHLFAFLGFLGSAINLRAGHYLAMTTLLLEMSTPFTCISWMLLKAGWSDSLFWKANQWLMIHMFHCRMILTYHMWWVCFCHWDALTSSLHLPHWALFLFGLALLTAVINPYWTHKKTQQLLHPVDWNFAQEEAKGSRQERTNGQVPRKKRL
Protein: D-methionine ABC transporter membrane protein (Q9HT69)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}.
Interaction partners:
- Methionine import ATP-binding protein MetN 2
- Probable TonB-dependent receptor
- Methionine import ATP-binding protein MetN 1
- Methionine ABC transporter substrate-binding protein
- MetQ/NlpA family ABC transporter substrate-binding protein
- Probable permease of ABC transporter
Sequence:
MDFFETMSFANIDWYEIWLASVDTFWMLGGSLLFTVVLGLPLGVLLFLTGPRQMFEQKAVYTLLSLVVNILRSLPFIILLIVMIPLTVLITGTSLGVAGAIPPLVVGATPFFARLVETALREVDKGIIEATQAMGASTRQIIWNALLPEARPGIIAAITVTAITLVSYTAMAGVVGAGGLGDLAIRFGYQRFQTDVMVVTVVMLLILVQILQTVGDKLVVHFSRK
Protein: GTP-binding protein 2 (Q9BX10)
Organism: Homo sapiens (Human)
Interaction partners:
- Protocadherin-7
- Ribosome-recycling factor, mitochondrial
- Protein pelota homolog
- DDB1- and CUL4-associated factor 17
Sequence:
MDSRVSELFGGCCRPGGGPAVGGTLKARGAGSSSGCGGPKGKKKNGRNRGGKANNPPYLPPEAEDGNIEYKLKLVNPSQYRFEHLVTQMKWRLQEGRGEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAEKVGADITVLREREVDYDSDMPRKITEVLVRKVPDNQQFLDLRVAVLGNVDSGKSTLLGVLTQGELDNGRGRARLNLFRHLHEIQSGRTSSISFEILGFNSKGEVVNYSDSRTAEEICESSSKMITFIDLAGHHKYLHTTIFGLTSYCPDCALLLVSANTGIAGTTREHLGLALALKVPFFIVVSKIDLCAKTTVERTVRQLERVLKQPGCHKVPMLVTSEDDAVTAAQQFAQSPNVTPIFTLSSVSGESLDLLKVFLNILPPLTNSKEQEELMQQLTEFQVDEIYTVPEVGTVVGGTLSSGICREGDQLVVGPTDDGCFLELRVCSIQRNRSACRVLRAGQAATLALGDFDRALLRKGMVMVSPEMNPTICSVFEAEIVLLFHATTFRRGFQVTVHVGNVRQTAVVEKIHAKDKLRTGEKAVVRFRFLKHPEYLKVGAKLLFREGVTKGIGHVTDVQAITAGEAQANMGF
Protein: STING ER exit protein (STEEP) (Q8VDP2)
Organism: Mus musculus (Mouse)
Function: Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29374277}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9H5V9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H5V9}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H5V9}. Nucleus {ECO:0000269|PubMed:29374277}. Note=Recruited to the endoplasmic reticulum following interaction with phosphorylated STING1 (By similarity). Detected in the nucleus and cell soma of pyramidal neurons in the brain cortex and Purkinje cells, as well as in neurons in the granular layer in the cerebellum (PubMed:29374277). {ECO:0000250|UniProtKB:Q9H5V9, ECO:0000269|PubMed:29374277}.
Interaction partners:
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-processing factor 17
- UPF3 regulator of nonsense transcripts homolog B
- THO complex subunit 4
- Serine/arginine repetitive matrix protein 1
- Spliceosome RNA helicase Ddx39b
- Developmentally-regulated GTP-binding protein 1
- Progranulin
- Tricarboxylate transport protein, mitochondrial
- DNA polymerase epsilon subunit 2
Sequence:
MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDAAKHAHKFCNTEDEETTYLRRPEGIERQYRKKCAKCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK
Protein: Sialidase-1 (EC 3.2.1.18) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1) (Q5JQI0)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}. Lysosome lumen {ECO:0000256|ARBA:ARBA00004227}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004207}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004207}; Lumenal side {ECO:0000256|ARBA:ARBA00004207}.
Interaction partners:
Sequence:
MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTMEQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGSTWSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVSWSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASWRYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKETVQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL
Protein: dual-specificity kinase (EC 2.7.12.1) (A8K7I0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
Protein: Histidine ammonia-lyase (Histidase) (EC 4.3.1.3) (P35492)
Organism: Mus musculus (Mouse)
Interaction partners:
- Urocanate hydratase
- Histidine decarboxylase
- Cytosolic non-specific dipeptidase
- Beta-Ala-His dipeptidase
- Carnosine synthase 1
- Probable imidazolonepropionase
- Formimidoyltransferase-cyclodeaminase
- Arginase-1
- Glycine dehydrogenase
Sequence:
MPRYTVHVRGEWLAVPCQDGKLTVGWLGREAVRRYMKNKPDNGGFTSVDEVQFLVHRCKGLGLLDNEDELEVALEDNEFVEVVIEGDVMSPDFIPSQPEGVFLYSKYREPEKYIALDGDSLSTEDLVNLGKGRYKIKLTSIAEKKVQQSREVIDSIIKERTVVYGITTGFGKFARTVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEAFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSPKSGWADAKYVLEAHGLKPIVLKPKEGLALINGTQMITSLGCEALERASAIARQADIVAALTLEVLKGTTKAFDTDIHAVRPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVVEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLESLRKNSATIPESDDL
Protein: Phosphoglycerate mutase family protein (F4JBU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable pectinesterase/pectinesterase inhibitor 36
- Putative inactive G-type lectin S-receptor-like serine/threonine-protein kinase SRK
- U-box domain-containing protein 8
Sequence:
MYTTITSNVVSKVTAAAATIRATMESAKSKNPDSYQNILMMRHGDRIDKIDPLWLDTAARPWDPPLVQDGMVRAFQTGQRIRSQIQFPIHRVFVSPFIRCIQTASEVIAALSAVDFDPNATSSKDVTSIDKYKLKVSIEFGLSEMLNSIAIKPEIAPKDGKFDFMISELEAIFPDGMVDHSVDPVYKEMPQWEETVEGCTDRFLSLIKTLADKYPSENLLLVTHGEGVRTTFATFKGVHVYDVEYCGCAELRRQVSSKDGSTKAGDFEVITSLSQCGIKYHSLSTTDQTSA
Protein: BRCT-domain protein MUS101 (Q9GTU6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSISMSMDETICAYFVNNLKPGDGGVQEADTLQQFEAARELLGQQLAETQIRQIKPSEGYPLIAAGNLTKKDVFVLTQFEGEFFEQLQQTRALILGPPCLITCLRRNEPIPEGSSAIYSTAMRDLQVSATGITPQKKEELSRLINWMGGIYFQSFGHRTTHLISNTIKSSKYEQATLNGVPVMHVDWVQYVWDQSRRSQREGIMATDPDFDKYRLPIFFGANITCSGLDVARKDQVMRLVNDNGGIYHRAFRSQVVDIVITEQTKTDTEKYKAAIRYKKDVLLPEWIFDSCNRGYALPTKDYEVRPGKTSSTPTKTTRPGAAPGADQTHLSDLSRISFVSGSRRMCSDLSTVNESVSSVGSSSPAKQLLKQATSSGRNYQQVLAEIEPRQAKKAGAFLDGCCVYLSGFRSEEREKLNRVLNTGGATRYDEANEGISHIIVGQLDDAEYRQWQRDGLMGSVHVVRLDWLLESIRAGRVVSELVHRVSMPQNREPDVASPASKRTLRSMNHSFKQPTLPIKKKLFDQEPDPVQEQEHEEPDHTLLDQYSQDQGAVAQLPPADVSLLQPAASSTQMDIRQRVSVANPKPPAEGLQLPDLSASTLSIDFDKLDYFAGVSVYVHRECFNEEFFNQMLTECEAAQGLLVPSSFSDEVDFAIVSFEVAFDVKQLPVKARHVVTELFLESCMKKNQLLPIEYYHKHVPATALRQPLKGMTIVVSIYAGLERDFINATAELLGASVNKTFIKKEKPLLVCPSAEGSKYEGAIKWNYPVVTSDWLVQCARTGQKLPFVGYLVGKSPEDFPISPRLRDSNSRTARRPNESTLVAQPDVTMEEAENQPAGSVTPVTAGSPGAPELTPLRNKRVSELAGIPGGSARHRGTSSTSSPDSPCTPLSQVGAQQYNLDFLEQFVQRLDTEEGKDCVREIIREMRENQTPELERIRRQACTPVSRKHQRPAPGIPDFCLTPEFQQRMADDFERRWRLPTMKIKPDTPLAVIRQRVMRITCETLGIEYEESNAKTPTLSESPSTVKKKPPTRTTQATKLNFDRSPKTPKLSLGKKTPLRVSMGSPRSGTQSPFVPNTQSPIEAAPPRRSDGPTLSEEGQSTINFDKISFEESAVPVLAPDVPTVAPDVKQITDYLKNCESRRNSLKRSHDNDMDCGESEVQYVQPFESEGFALGTEDMVDWRDPAEFNAAKRRSSGGSPKMQYAGIPCFSISCGDDDEKRAELIARITQLGGKVCENLVNYDDSCTHLLCERPNRGEKMLACIAAGKWILNIQYIEQSHARGDFLDETLYEWGNPKAINLPTLAPEEEPIAAAVHRWRTELSACGGGAFSDHRVILSMNERSGAPIRNVLRAGGACILEPTTPFSKDPVAKSASHCFVDVKKAPLSTQDMEYLHKCGVQVLSQIAINAYLMNGRDADLGKYQLL
Protein: EGF-like domain-containing protein (I1LEE5)
Organism: Glycine max (Soybean) (Glycine hispida)
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000256|ARBA:ARBA00029430}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00029430}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004614}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004614}. Prevacuolar compartment membrane {ECO:0000256|ARBA:ARBA00043947}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00043947}.
Interaction partners:
Sequence:
MKLRRSSLCVFLGFLVLFLSPPPSMAKFVVEKNSLTVTSPDDIKGTHDSAIGNFGIPQYGGSMAGNVLYPKDNKKGCKEFDEYGISFKSKPGALPTIVLLDRGNCFFALKVWNAQKAGASAVLVSDDIEEKLITMDTPEEDGSSAKYIENITIPSALIEKSFGEKLKVAISNGDMVNVNLDWREAVPHPDDRVEYELWTNSNDECGVKCDMLMEFVKDFKGAAQILEKGGYTQFTPHYITWYCPQAFTLSKQCKSQCINHGRYCAPDPEQDFSTGYDGKDVVIENLRQLCVFKVANETKKPWVWWDYVTDFQIRCPMKEKKYNKKCADAVIESLGLDIKKIERCMGDPNADSENPVLKEEQDAQVGKGSRGDVTILPTLVVNNRQYRGKLEKGAVMKAICAGFEETTEPAVCLSSDVETNECLENNGGCWQDKVANITACKDTFRGRVCECPLVDGVQFKGDGYTTCAASGPGHCKINNGGCWHEARNGHAYSACSDDGGVKCKCPAGFKGDGVKNCEDIDECKEKKACQCPECSCKNTWGSYDCTCSGDLLYIRDHDTCISKTASQEGRSAWAAFWVILIGLVVAAAGAYLVYKYRIRSYMDSEIRAIMAQYMPLDSQGEIVNHVSEERA
Protein: Importin N-terminal domain-containing protein (Q5AYN9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Importin subunit alpha
- GTP-binding nuclear protein
- Exportin 1
Sequence:
MADLQSIAQLLAASSDRTQTKQAEAALRQQESNPNFPISLLQITASDSYPLGTRLSSAILFKNVIRRNWTDEDGNYKLPLEVVGTLKQELINLMISVPQVLQTQLGEAVSVIADSDFWERWDTLVNDLVSKLQPDNPSVNIGVLQVAHSIFKRWRPLFRSDDLYIEINHVLERFGTPFLTLFQGLDTYLETNKSNKDQLTQGFTQLNLMVKLVYDLSCHDLPPMFEENMSGLAQILLKYLTYDNQLLHTDDDAESGQLEYVRAGIFEVLTLYVQKYGDEFQPYIQQFVESSWNFLTTIGQETKYDILVSRALKFLTSIAGMPQHAQIFQAESTLAQVIEKVVLPNVSLRESDEELFEDEPIEFIRRDLEGSDSDTRRRAATDFLKQLNANFEASVTKAVLQYIEHYLNEYGKSPQLNWKAKDTATYLFIAIAAKGVATATHGVTTTNSLISITDFFQKNLAADLVSGDGVHPILKVDAIKYLYLFRSLITKEQWQEVFPLLVNHLGSSNFVVYTYAAIAVERVLYFTDNQGQPIVSPDTIRPLAKDLLEHIFSLIQKNPAPEKVQENEFIMKCAMRVLIVIKEGVVPITDNVLAHLINITQIISGNPSNPRFYYYHFETLGAFIRFAAPSNPDKLEQALYPPFSAVLQADIAEFVPYIFQLFAALLEANPSGTLPTYYHGLIAPILAPQVWESKGNIPALVRLLSSIIARGSQHILENNQLINTLGIFQKLLSSKTNEGYGFDLLEAVIEHFPSAALEPFFKDIMQIILTRLQNHKTESLTLRFVRFYHFMCANDAKGYSADFVIQVIDKVQEGLYVQLYLNIILPESQKLARPMDRKTAVISFTKTLANSEAFAVKYKKGWGFTCEALLKLLELPPLPASKDDIIAEHDVEDMAFGVGFTALVTIRPQARDPWPDTGADLKLWVGKYLKEADQRHGGKISGFVQERLGEQAKAMLSSYIA