wanglab/gogpt-training-data huggingface dataset:
Protein: Baeyer-Villiger monooxygenase (BVMO) (EC 1.14.13.-) (Q9RKB5)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters or lactones using NADPH and/or NADH as an electron donor. Thus, can convert bicyclo[3.2.0]hept-2-en-6-one into the oxidative lactone products 2-oxabicyclo[3.3.0]oct-6-en-3-one and 3-oxabicyclo[3.3.0]oct-6-en-2-one. Is also able to catalyze the sulfoxidation of methyl phenyl sulfide (thioanisole).
Interaction partners:
- MerR-family transcriptional regulator
- Hydrolase
- Probable 3-oxoacyl-[acyl carrier protein] reductase
- Esterase
- Flavin-dependent reductase
Sequence:
MAEHEQVHEHVRVAVIGSGFGGLGAAVRLRREGITDFVVLERAGSVGGTWRDNSYPGCACDVPSHLYSFSFAPNPEWPRTFSGQEHIRAYLEHVADTFGLRPHLRFDSEVKRMAWDTEQLRWEIETVRGTLTADVVVSATGPLSDPKVPDIPGLDTFPGKVFHSARWDHDYDLAGQRVAMIGTGASAIQIVPSIQPKVDRLTLFQRTPAWVMPRVDRAISGAERALHRALPATTKLRRGLLWGIRELQVQAFTKHPNELGFVEQIAKRNMGAAIKDPALRAKLTPDYRIGCKRILLSSTYYPALAKPNVDVVASGLSEVRGSTLVAADGTEAEADAIVFGTGFHVTDMPIAERVVGADGRTLAETWKGGMEALRGGTAAGFPNFMTVIGPNTGLGNSSMILMIESQLNYLADYLRQLNVLGGRTALDPRPAAVRNWNHRVQERMKRTVWNTGGCTSWYLDASGRNTTVWPGTTAEFRRETRRVDLAEYQVLRPAPAQVGAKAAEADTGADTGADAEVSA
Protein: 16.9 kDa class I heat shock protein 2 (16.9 kDa heat shock protein 2) (OsHsp16.9B) (Q943E6)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- 18.1 kDa class I heat shock protein
- 16.9 kDa class I heat shock protein 3
Sequence:
MSLVRRSNVFDPFSLDLWDPFDSVFRSVVPATSDNDTAAFANARIDWKETPESHVFKADLPGVKKEEVKVEVEEGNVLVISGQRSKEKEDKNDKWHRVERSSGQFMRRFRLPENAKVDQVKAGMENGVLTVTVPKAEVKKPEVKAIEISG
Protein: Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) (Q5M9I5)
Organism: Rattus norvegicus (Rat)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00127}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00127}; Intermembrane side {ECO:0000250|UniProtKB:P00127}.
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 1, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome b
- Ubiquinol-cytochrome c reductase, complex III subunit X.
- Cytochrome b-c1 complex subunit 7
- Cytochrome b-c1 complex subunit 10
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c oxidase subunit 6B1
Sequence:
MGLEDERKMLTGSGDPKEEEEEELVDPLTTVREHCEQLEKCVKARERLESCDRRVSSRSQTEEDCTEELFDFLHARDHCVAHKLFKSLK
Protein: Transcription factor TCP6 (Q9FLM6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor TCP18
- Transcription factor TCP12
- Transcription factor TCP13
- Transcription factor TCP3
Sequence:
MVMEPKKNQNLPSFLNPSRQNQDNDKKRKQTEVKGFDIVVGEKRKKKENEEEDQEIQILYEKEKKKPNKDRHLKVEGRGRRVRLPPLCAARIYQLTKELGHKSDGETLEWLLQHAEPSILSATVNGIKPTESVVSQPPLTADLMICHSVEEASRTQMEANGLWRNETGQTIGGFDLNYGIGFDFNGVPEIGFGDNQTPGLELRLSQVGVLNPQVFQQMGKEQFRVLHHHSHEDQQQSAEENGS
Protein: Protein FAM168A (Tongue cancer chemotherapy resistance-associated protein 1) (Q92567)
Organism: Homo sapiens (Human)
Function: In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.
Interaction partners:
- NEDD4-like E3 ubiquitin-protein ligase WWP2
Sequence:
MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYATLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAPPPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAIYPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYVPPHW
Protein: LYR motif-containing protein 2 (Q9NU23)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000305|PubMed:31666358}.
Interaction partners:
- Acyl carrier protein, mitochondrial
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- Electron transfer flavoprotein regulatory factor 1
- LYR motif-containing protein 1
- LYR motif-containing protein 9
- LYR motif-containing protein 4
Sequence:
MAASRLPPATLTLKQFVRRQQVLLLYRRILQTIRQVPNDSDRKYLKDWAREEFRRNKSATEEDTIRMMITQGNMQLKELEKTLALAKS
Protein: RNA ligase 1 (EC 6.5.1.3) (RNA ligase) (Rnl) (Q8BHN7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MKRLGSVQRKMPCVFVTEVKAEPSAKREHQPFKVLATETLSEKALDADVYNAVATEKVDGTCCYVTNYKGQPYLWARLDRKPNKQADKRFKKFLHSKESAKEFHWNTEEDFKPVPECWIPAKEIEKQNGKPVPDENGHIPGWVPVEKGSKQYCWHSSVVNYEFGIALVLRHHPDDPGVLEISAVPLSELLEQTLELIGTSINGNPYGLGSKKSPLHFLTPHGAFQVRNLPTLKHNDLLSWFEDCREGQIEGIVWHCGDGCLIKVHRHHLGLCWPLPDTYMNSKPVIINMNLNLNNYDCAFDNQSLFNQFSKIDKQKFERLKDIILDV
Protein: Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain] (D3ZAW2)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity).
Subcellular location: [Phosphatidylserine decarboxylase beta chain]: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:6862014}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:6862014}.; SUBCELLULAR LOCATION: [Phosphatidylserine decarboxylase alpha chain]: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:6862014}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:6862014}; Intermembrane side {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:6862014}. Cytoplasm {ECO:0000250|UniProtKB:Q9UG56}. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain. {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000305|PubMed:6862014}.; SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9UG56}. Lipid droplet {ECO:0000250|UniProtKB:Q9UG56}. Note=Predominantly localizes to lipid droplets in lipid-replete conditions, and to mitochondria in lipid-deplete conditions. {ECO:0000250|UniProtKB:Q9UG56}.
Interaction partners:
- Phosphatidylserine synthase 1
- Phosphatidylserine synthase 2
- Phosphatidylethanolamine N-methyltransferase
- Choline/ethanolaminephosphotransferase 1
- Phospholipase D2
- Phospholipase D1
- Selenoprotein I
- Membrane-bound glycerophospholipid O-acyltransferase 2
- Membrane bound O-acyltransferase domain containing 1
- Phospholipase A1 member A
Sequence:
MAVAGGRGCVRSLREGVLWRSSPCHCDYTATRHFLGALQKLPLQAWVRKVHTAPLRTLFLLRPVPILLAAGGGYAGYRQYEKYRERQLEKLGLEIPPKLASHWEVSLYKSVPTRLLSRACGRLNQVELPSWLRRPVYSLYIWTFGVNMTEAAVEDLQHYRNLSEFFRRKLKPQARPVCGLHSVISPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRACTEDLPFPPASSCDSFRNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFDQDLHTNSPSYSKGSYNDLSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKILFGEALGSL
Protein: Elongation factor 2 (Q38BE4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- 40S ribosomal protein S15, putative
- Small ribosomal subunit protein uS4
- 40S ribosomal protein S27, putative
- 40S ribosomal protein S4
- 60S ribosomal protein L35A, putative
- 60S ribosomal subunit protein L31, putative
- Ribosomal protein L37
- 40S ribosomal protein S5, putative
- 40S ribosomal protein S13, putative
- 60S ribosomal protein L27a
Sequence:
MVNFTVDEVRALMDYPEQIRNMSVIAHVDHGKSTLSDSLVGAAGIIKMEDAGDKRIMDTRADEIARGITIKSTAISMHYHVPPEIISDLPDDRRDFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQALTERIRPVVFINKVDRAILELQLDPEEAYQGFVKTLQNVNVVIATYNDPVMGDVQVYPEKGTVAIGSGLQAWAFSVTRFAKMYASKFGVDESKMCERLWGDNFFDAKNKKWIKSETNAAGERVRRAFCQFCLDPIYQIFDAVMTEKAEKVEKMLKSLNINLTTEEREQVPKKLLKSIMMKFLPAAETLLQMIVAHLPSPKKAQSYRAEMLYSGESNPDEKYYMGIKNCDPNAPLMLYISKMVPTADRGRFFAFGRIFSGKVRCGQKVRIMGNNYIHGKKQDLYEDKPVQRTVLMMGRYQEAVEDMPCGNVVGLVGVDKYIVKSATITDDGESPHPLRDMKYSVSPVVRVAVEAKNPSDLPKLVEGLKRLAKSDPLVVCSIEESGEHIVAGAGELHLEICLKDLQEDFMNGAPLKISEPVVSFRETVTDVSSIQCLSKSANKHNRLFCRGAPLTEELCVEIEDGANAGSEADPKTRARFLADKFEWDVAEARKIWCYGPDNRGPNVVVDVTKGVQNMMEMKDSFVAAWQWATREGVLCDENMRGVRINVEDVTMHADAIHRGGGQIIPTARRVFYACCLTATPRLMEPMFQVDIQTVEHAMGGIYGVLTRRRGVIIGEENRPGTPIYNVRAYLPVAESFGFTADLRAGTGGQAFPQCVFDHWQQYPGDPLDPKSQANTLVLSIRQRKGLKPDIPGLDTFLDKL
Protein: Serine palmitoyl CoA transferase subunit LCBA (Q5B6V2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- serine C-palmitoyltransferase
- Aminotransferase class I/classII large domain-containing protein
- 3-ketodihydrosphingosine reductase tsc10
- Evolutionarily conserved protein with similarity to Orm2p
- non-specific serine/threonine protein kinase
- TORC1 growth control complex subunit Kog1, putative
- Target of rapamycin complex subunit LST8
- Tryptophan synthase
- tryptophan synthase
- Serine hydroxymethyltransferase
Sequence:
MDVQETQRLLSEYLHELANLFHRVPGSAIFLRYVKSSYQNDPIRSAVELFLFLFAVRYLLAPKYSTKPGVVQLSEDEIDDLVDEWTPEPLVGKPTALEEMEIDKRPVIAGPVGPKVRLSNGRTVMNLGSYNFYNFNTNESIKEKAIQTLRNYGVGPCGPRGFYGTQDVHMKTEADVASYLGTASCIIYSQAFSTISSVIPAFSKRGDIIVADKGVNFAIRKGIQISRSIVRWYEHNDMEDLERVLAKITKEQARKPLTRRFIITEGLFESYGDMSDLPKIIELKLKYKFRLILDESWSFGVLGRTGRGITEHQNVDAAEVDMIVGSLAGPLVAGGGFCAGSEEIVHHQRISAAAYTFSAALPALLSTTASATINILQNSPETISHLRDLTKAMWAQLDPRSDWVRCTSAPENPILVLVLKPEVVAAKRLSHEDQQYVLQDVVDECIANGVLITRLKCLDDNFEPKQNVPAALKVCVTTGLTKKEIEKSGTIIRHAITKVLSKRK
Protein: Ardp (A0A1D8PPB1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MDSAYWSYDNIVPSFRLDGKLVILTGGSGGLAAVVSRALLAKGADVALVDMNLERTQQAARDVLQWGEEQMKGKYESPIGQVSAWSCNIGDAEAVDLTFKAINEHHGKISSVLVNTAGYAENFPAEEYPAKNAENLMKVNGLGSFYVSQAFARPLIQNNMTGSIILIGSMSGTIVNDPQPQCMYNMSKTGVIHLARSLACEWAKYNIRVNTLSPGYILTPLTRNVISGHTEMKTEWESKIPMKRMAEPKEFVGSILYLASESASSYTTGHNLVVDGGYECW
Protein: Putative actin-22 (EC 3.6.4.-) (Q553U6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 1
Sequence:
MDGEDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFEAEMQTAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTFNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTSLAPSTMKIKIVAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPSIVHRKCF
Protein: Major vault protein (MVP) (Q9EQK5)
Organism: Mus musculus (Mouse)
Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14764}. Nucleus {ECO:0000250|UniProtKB:Q14764}.
Interaction partners:
- Protein mono-ADP-ribosyltransferase PARP4
- Telomerase protein component 1
- Myeloid differentiation primary response protein MyD88
Sequence:
MATEEAIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPVRMVTVPPRHYCIVANPVSRDAQSSVLFDVTGQVRLRHADQEIRLAQDPFPLYPGELLEKDITPLQVVLPNTALHLKALLDFEDKNGDKVMAGDEWLFEGPGTYIPQKEVEVVEIIQATVIKQNQALRLRARKECFDRDGKERVTGEEWLVRSVGAYLPAVFEEVLDLVDAVILTEKTALHLRARQNFKDLRGVAHRTGEEWLVTVQDTEAHVPDVYEEVLGVVPITTLGPRHYCVILDPMGPDGKNQLGQKRVVKGEKSFFLQPGERLERGIQDVYVLSEQQGLLLKALQPLEEGEGEEKVAHQAGDRWLIRGPLEYVPSAKVEVVEERQAIPLDQNEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPSGVEELLNLGHDPLADRGQKGTAKVLQPSAARNKTRVVSYRVPHNAAVQVYDYRAKRARVVFGPELVSLDPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELKNRNDPEETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRMAVFGFEMSEDAGPDGALLPRARDRAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAMSMAVESTGNAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELERVKKVREMELIYSRAQLELEVSKAQQLADVEAKKFKEMTEALGPGTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSSPINLFNTAFGLLGLGSDGQPPVQK
Protein: Cystatin-C (PoCystatin-C) (B2Z450)
Organism: Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus)
Function: Thiol protease inhibitor. Has high papain inhibitory activity and inhibits to a lesser extent fish cathepsins L, S, K, F, X and bovine cathepsin B in vitro.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q98967}.
Interaction partners:
Sequence:
MKMLVFPVLAALFAVGLGNLVGAPRDINISEAQDALDFAVAKHNSGTNDMFLRQVAEVVRVQRQVVSGNKYIITVKMAKTPCRKDRVVNEVCEIHKDPALAQPYECTFSVWSRPWIPDLQLVGEKC
Protein: C11.1 (Q9NHY0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDGRGVGGGGSGAATGGGSANNKSAAGNSAATGNADASTATAAPNDKPTILEGVLHNIFDGLMDKEEQVRIAMQQAIVKILETHPERAAEILSEHRSQQPKMTDQTVAMLLDCIRRVVGAETPLPPAANQKLIDLALQELTKNPEHLPLIQNPAQRILVAIGRSSPESCEQVMEALQEKGTSTEGVAHFMLMQCLGLLATENPAGVVPHIKAILSRSQPHLVGIRQDHIKQAHAYAIGRFSEALLEESGKKEEENCSTEISVAYDVLFNQWLHSREPKVCVEILQALSSMYPLLPKDRIQDQAARLVPQILALYRRSVDRNAVTQFLCSVLKTNLALNATVLDGIIDVLVTHLFDLVCVYPDYEKPQTVKGHYEVLRCFHLLAGHQPYSTRIMDTLLIHLRNNSERERMKSLLILTHLLNSCAGNIENRIPATIECLKQLILSERGIKMKLTLLKTIVALAQKSHIRDKEFVWFVVRHSCRFSKPSQEHGSQEEHANLVLSCENTLYMLASTVGTLDELLKRELLNYLILLDYTDICGNLAKCLASLFAKSPHIEYDIAGDDAATEQATPESMGAAGEDRSVIKRGKVMVPGAETIYARCLALLGNQQCIKRCSNILSFLRYYHPQVNPALEELWERKIPDLLLQINRESAYRQLLHDFVLETNEFLGGLDENFAQRLASKLADQMYLYPMQLPHSEWHLPDLSAERGMLLQAVALTLLQVTDVACIHTKIDLIVTTARQERLDKHVKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVGGRKHSTGFFSNLHFIKDTHKELENYKSNLLVVKAFGRIMDEADPLQSIQHLDEDDTLLGFLIQQLAVHKDQTIMSAILQTLLSICNQLIATKEQLPAPLRHRKQIMETVFNIPIEAPFHDLPLLPTILKLGTDFIRIGGPDTEECVDGGVIFEIACRNFFGCAQQLKMKFDSQEEDERNSFLAKHLNESLPQLNALVRAIVELDASPATLDLIIGILEGWTRDRNSEVRICASHVFNNTLDVYIKSMKIGCEAPSKFNQTGQMLGKIVPRCIDSNGTVRQVSVEILQKTLEIACIYETLTIASIDSTADWLKEIETIKEHIITDEPKQIYNLAGDIAKIIALRISSFQYLQFCKTLLHSLRDPEQSSTIGASVVLKFFIQQKGSELFHAIPDLVRDSLLALRVCEVPRAKSGVLKALVALTKHHPKLVCAEMLSQPLPYDPNLVEYWHLVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSERQKLASGQPFAIFCALHEMLPCKDIKGQLETRFADMFCMLLTSLSSYTNLAAPNPINNASLSPNQTQSGKTKFGFVPNKELIKLNPCQIALETFQAFLTNLEMEQIASVLTVNTQLASSADWHNYIELLTPMAIGLGQ
Protein: Transcription activation suppressor (A0A087X0F1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFPYDSRLDDKKFLYSAPRNKSHIDTCLHAYIFRPEVYQLPICKLKELFEENRKLQQFSPLSDYEGQEEEMNGTKMKFGKRNNSRGEAIISGKQRSSHSLDYDKDRVKELINLIQCRKKSVGGDSDTEDMRSKTVLKRKLEDLPENMRKLAKTSNLSENCHLYEESPQPIGSLGHDADLRRQQQDTCNSGIADIHRLFNWLSETLANARHSDASLTDTVNKALGLSTDDAYEELRQKHEYELNSTPDKKDYEQPTCAKVENAQFKGTQSLLLEVDATSKYSVAISTSEVGTDHKLHLKEDPNLISVNNFEDCSLCPSVPIEHGFRRQQSKSNNVEETEIHWKLIPITDTLKGTTEDDVLTGQVEEQCVPAAEAEPPAVSETTERTVLGEYNLFSRKIEEILKQKNVSYVSTVSTPIFSTQEKMKRLSEFIYSKTSKAGVQEFVDGLHEKLNTIIIKASAKGGNLPPVSPNDSGAKIASNPLERHVIPVSSSDFNNKHLLEPLCSDPLKDTNSDEQHSTSALTEVEMNQPQHATELMVTSDHIVPGDMAREPVEETTKSPSDVNISAQPALSNFISQLEPEVFNSLVKIMKDVQKNTVKFYIHEEEESVLCKEIKEYLIKLGNTECHPEQFLERRSKLDKLLIIIQNEDIAGFIHKIPGLVTLKKLPCVSFAGVDSLDDVKNHTYNELFVSGGFIVSDESILNPEVVTVENLKNFLTFLEELSTPEGKWQWKVHCKFQKKLKELGRLNAKALSLLTLLNVYQKKHLVEILSYHNCDSQTRNAPELDCLIRLQAQNIQQRHIVFLTEKNIKMLSSYTDNGIVVATAEDFMQNFKNLVGYHNSITEENLPQLGANENLESQSALLENDEKDEEDMSLDSGDEISHIEVCSNFHSEIWEKETKGSRGTDQKKNTQIELQSSPDVQNSLLEDKTYLDSEERTSIDIVCSEGENSNSTEQDSYSNFQVYHSQLNMSHQFSHFNVLTHQTFLGTPYALSSSQSQENENYFLSAYTESLDRDKSPPPLSWGKSDSSRPYSQEK
Protein: Histone deacetylase 6, isoform F (EC 3.5.1.98) (M9NEH6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLRDIWIQSPPIVTRRSAQQAKIQTRAMASKSKTGTTGAATAAGGTGSSSGSISGGFNAADPRKSNKPNAALLEAKRRARNNMLKNQGCGSQESVTDIFQNAVNSKSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKEEDLHTVLRHWIGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGRRLPRDPVVGENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGDERPSGSKPKVKVKTLSDYLAENKEALEQSEMFAVYPLKTCPHLRLLRPEEAPRCKPMQSGEDSLPFWSR
Protein: Bromodomain adjacent to zinc finger domain 2A (J3KPG5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPSVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQYPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEEVGSGIHPDEAAEKEMTSVVAENGTGLVGSLELEEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEDSLEPFNSLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQTSTSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSSDFPPSLTQPAPDQSSTIQLHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPASSAVLPAVSLEVPLTASVTSPKASPVTSPAAAFPTASPANKDVSSFLETTADVEEITGEGLTASGSGDVMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLKAALHDPGFPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRTQPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVLAKRTGRSEVEMEGPEECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRRGRRDGEVDATASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTEGNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSMQPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQSQHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESSPDPQALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWWWIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIFEPRQLPAFQEGIMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDSTREDLAYCEHLSDSQEDITWRGRGREGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPTHEVVLEKALLSTPNGAPEGTTTEISYEITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQKPGFPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL
Protein: Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8) (Q9JLZ8)
Organism: Mus musculus (Mouse)
Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Interaction partners:
- Myeloid differentiation primary response protein MyD88
- Interleukin-1 receptor-associated kinase 1
- Toll-like receptor 4
- Interleukin-33
- TNF receptor-associated factor 6
- Interleukin-1 receptor-associated kinase 3
- Toll-interacting protein
- Toll-like receptor 5
- Interleukin-18 receptor 1
Sequence:
MAGVCDMAPNFLSPSEDQALGLALGREVALNCTAWVFSRPQCPQPSVQWLKDGLALGNGSHFSLHEDFWVSANFSEIVSSVLVLNLTNAEDYGTFTCSVWNVSSHSFTLWRAGPAGHVAAVLASLLVLVVLLLVALLYVKCRLNMLLWYQDTYGEVEMNDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRPWCSQSFREGLCRLLELTRRPIFITFEGQRREPIHPALRLLRQHRHLVTLVLWKPGSVTPSSDFWKELQLALPRKVQYRPVEGDPQTRLQDDKDPMLIVRGRAAQGRGMESELDPDPEGDLGVRGPVFGEPPTPLQETRICIGESHGSEMDVSDLGSRNYSARTDFYCLVSEDDV
Protein: adenylate cyclase (EC 4.6.1.1) (M0R5U4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Guanine nucleotide-binding protein G
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Guanine nucleotide-binding protein G
- Adenylate cyclase type 6
- Adenylate cyclase type 3
- Rap guanine nucleotide exchange factor 3
- Rap guanine nucleotide exchange factor 4
- Protein kinase C gamma type
- Protein kinase C beta type
Sequence:
MASSPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNTHPKHCKYSISSSCSSSGDSGGLPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYVGFACLLWSIYFAVHMRSKVIVMVVPALCFLVVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVWTPLSGRVDSPNHTLTAKAADTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLFLGVVYSVLFETFGYHFRNEDCFPSPDPGALHWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKASIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVMERLGQSVVADQLKGLKTYLISGQRAKESHCSCAEALLSGFEVIDDSRVSSGPRGQGTASPGSVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAVQNGCQDEPKASTKVTSSWLLFLSVPLLAHPPKASGGPNSKTQNGLLSPPAEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPISQFSLNFLDQELEQSYRASYQEEVIKNSPVKTFASATFSSLLDVFLSTTVFLILSITCFLKYGATATPPPPAALAVFGADLLLEVLSLIVSIRMVFFLEDVLTCTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHITSEFETNINFTMLTGSAVLVAVVHYCNFCQLSSWMRSSLATLVGAGPLLLLYISLCQDSSIVMSPLDTAQNFSASERSPCNSSVLQDGRRPASLIGKELILTFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDNGVVPQHQLSISPDIRVQVDGSIGRSPTDEITNLVPSVQYLDKASLGSDDGAQTKEATLSSKRPWREPVKAEERFRFGKAIEKEDCEDTGAEEANELTKLNVSKSV
Protein: Transcription factor EB (B1AKB1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQMPNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKREL