wanglab/gogpt-training-data huggingface dataset:
Protein: High-affinity glucose transporter ght5 (Hexose transporter 5) (P78831)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: High-affinity glucose transporter.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- SNF1-like protein kinase ssp2
- DNA-binding protein scr1
- Arrestin domain-containing protein C584.15c
Sequence:
MGKNLTIVMLVFVSMAGWMFGADTGSIGGITNMRDFQSRFADRYNPVTDSYSYSSARQGLITGMVNVGSFFGCFLSSPLMDRIGKRTSIMFWTIVYLIGIILQVTAVPSWVQIMVAKIWTGLSIGALSVLAPGFQSEVAPADLRGTIVTTYQLAVTGGIFIAACINMGTHKLHKTAQWRVSMGINLLWGIITFIGISFLPESPRYLISVGRDEEALQIMAKNNDLPIEHEVIQTEYHVIKSDCEAELAGGPATWPEIFGPDIRYRTFLGLGVMSLQQLTGDNYYFYYGFEVFEGTGMNSPYLSALILDAVNFGCTFGGLFVLEFFGRRMPLIIGALWQSITFFIYAAVGNRALTRKNGTSNHRAGAVMIVFSCLFIFSFAQTWGPAAYVIVGESYPIRYRSKCAAVATTGNWLWGFLISFFTPFITNSIGFKYGYIFAACNLCAACIIFLFAHETKGLTLEEINELYISGAKPWMPRPKNLGNFTKQQEEVREKSRGVQGESAAHLENVDGEEGIEDSSNDISSTTSSDGRAKPESSYHDQEEQFA
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 (A0A8I6AMA8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATTAGGGPGAAAGAVGAGGAAAASGLAVYRRKDGGPASKFWESPDTVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVVQLLQFQEDAFGKHVTNPAFTKLPAKCFMDFKAGGTLCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYLIPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYPSSQEDEEWLRPVMRRDKQVLVHWGFYPDSYDTWVHSNDVDAEIEDAPIPEKPWKVHVKWILDTDVFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRERKASANARKRKHSPSPPPPTATESRKKSGKKGQASLYGKRRNQKDEDEQEDLTKDMEDPTPVPNIEEVLLPKNVNPKKDSENTPVKGGTVADLDEQDEEAVTTGGKEDEDPSKGDPSRSADAGEDNVTEQTNHIIIPSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLTGDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVPAAQQMLNFPEKNKEKPIDLQNFGLRTDIYSKKTLAKSKGASAGREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLENSDASLGPLAYQPVPFSQSGNPVMSTVAFLASVVDPRVASAAAKAALEEFSRVREEVPLELVEAHVKKVQEAARASGKVDPTYGLESSCIAGTGPDEPEKLEGSEEEKMETDPDGQQPEKAENKGENESDEGDKIQDGENEKNSEKERDSDTSEDVKPEEKENEENKELTDTCKERESDTGKKKVEHEISEGNVATAAAAALASAATKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRARQQMEQQQHGQPPQQAHQHPGGPGLAPLGAAGHPGMMPHQQPPPYPMMHHQMPPPHPPQPGQIPGPGSMMPGQPMPGRMIPTVAANIHPTGSGPTPPGMPPMPGNILGPRVPLTAPNGMYPPPPQQPPPPPADGVPPPPVPGPPASATP
Protein: thymidine kinase (EC 2.7.1.21) (Q8MX28)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MHDGDGNIELIIGPMFAGKTTELMRRVQRHKHAQRSCYIINYSRNSYQNQRLSTHDQLSLTANVSIAKLSEVCDEWRDYDVIAVDNGQFFPDVVGFCARAANEGKTVIVSALDVDCRETPFDEVCRLVPRAESVLKLSAVCMKCHEHDAFLTYRTIESNERELYGGADMYLAVCRWCYKQLTMSHVDAQKTSASTAAVVPNGAHGRIELIIGPMFAGKTTELMRRVQRHKHAQRSCYIIKYAGDTRYSEGAITSHDQRALTANVSVSNLHDVGDEWRKYDVIAVDEGQFFPGVAAFCSKAADSGKVVIVSALDADYLQEPFEEICLLVSRADSVVKLSAVCMECHNRKASFTYRTVKSDERKLVGGSDMYMSVCRSCYETKRNMVQTEKYIYSCVGINEGSYSECSPGPSERSSAGTSGVQTSVKVDEQNCTEPNTEAKKMPLKRKRNQMAVDTT
Protein: S100P-binding protein (A0A0S2Z5M0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMCSRVPSEQSSGTSLLPKDGAPFSWDSLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSGEDDGGHVEKGERGSQILLDTPREKNSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVTVAPFNPTVCDALLDKDETDSSKDTEKLSSLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSSSNNNFQQTVSDKNMPDSENPTSVFSRISDHSETPNMELSCRNGGSHKSSCEMRSLVVSTSSNKQDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIEDPEDTNQGISGELCALMDQVHHMQHSKWQHPSDLTTRNYARRQKHLQRYSLTQWVDRNMRSHHRFQRLPDFSYS
Protein: Keratin-associated protein 5-1 (Keratin, cuticle, ultrahigh sulphur 1-like) (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1) (Q6L8H4)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 5-5
Sequence:
MGCCGCSGGCGSSCGGCGSGCGGCGSGCGGCGSGCGGSGSSCCVPVCCCKPVCCRVPTCSCSSCGKGGCGSSGGSKGGCGSCGGCKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSGCGGCGSSCCVPVCCCKPMCCCVPACSCSSCGKGGCGSCGCSKGACGSCGGSKGGCGSCGGCKGGCGSCGGSKGGCGSGCGGCGSGCGVPVCCCSCSSCGSCAGSKGGCGSSCSQCSCCKPCCCSSGCGSSCCQSSCCKPCCSQSSCCVPVCCQCKI
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q0E965)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNKADVNRRVLAIQAKKKRHKNRKRGKQNGTNPQEQSNSSQNQNPKPSSNPIPEPNRSSENLQAPDNANNSHLNAPSSAAFSKATATATASTSSGGSAGTPDQYQPPKKTQAKAKPNTQKEHQQQPPRSSSNESYESETFSDNEDQELMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYPSLVSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAGQPSRKQREERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWLR
Protein: Activator of transcription and developmental regulator AUTS2 a (Autism susceptibility candidate 2a variant 4b) (A0A1X9RK91)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MFASPAALPPPPPLTSNTLPVPGHPAGSAYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHQHQHTHQHTHQHTFTPFPHAIMPTPAPPMVRTPARNFEKYPTKVDPFYRHSLFHSYPPAVSGIPPVIPPTGPFGSLQGAFQPKTSNPLDVAARPGAVPHTLLQKDPRLTDPFRPVLRKPGKWCAMHVHIAWQIYHHQQKVKQQMQVDPHKLDFGLKPEFLSRPPGPTLFGAIHHPHDLARPASLFSAAGSTHPAAAPFGHPPHHPSNFLTPAPHLEPFSRPPSFGGLASLSTAAFGGLGNPALASNSVFGHKDSPSAQQHFSGPHEPWNRLHRTPPSFPTPPPWLKPGESERSASVSSHERERERDRERERDLDKRDSSVNKDDKEREPVEKRHQNHQSPLPVNPLTLLGHTRPSEPSRNHISSSEPRDKDKDKPKDRERDREHSDWKDSNTDEHKLKENHHSDKDTPVIHDGRVSEDKPANRITASPYMRPGGMDRVNGGLTRDILEKKAEITYEKKNSEVKVKEERKEEQDGPTERSPEQRSTPQAPPPPPPAALHPPSSMPVPMGMASMHPINSISSLERTRMVAPFMGISPIPGAERFPYPAFHWDPMRDPYRGLDIHRRDPLARELLLRNDPLHRLAAPRLYEAERSYRDREPHDFNRDHPHGLTLEQRREQERAHLEERERLHLLREDYEQGRLHPMHHPVLDGHLPHPGLMAPGLPSMHYPRVSPSSAVAAAAQNGILNKTPPTASLSAPPPLIPTLGARSSSPRRTTPLGPDIRDRPPSHTHKDIEAR
Protein: SRY-box transcription factor 30 (cDNA FLJ53881, highly similar to Transcription factor SOX-30) (B4DXW7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEKCCRGKEQSLLCIQQGIPDTPFSKDRNGHVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEKHREEFPGWVYQPRPGKRKRFPLSVSNVFSGTTQNIISTNPTTVYPYRSPTYSVVIPSLQNPITHPVGETSPAIQLPTPAVQSPSPVTLFQPSVSSAAQVAVQDPSLPVYPALPPQRFTGPSQTDTHQLHSEATHTVKQPTPVSLESANRISSSASTAHARFATSTIQPPREYSSVSPCPRSAPIPQASPIPHPHVYQPPPLGHPATLFGTPPRFSFHHPYFLPGPHYFPSSTCPYSRPPFGYGNFPSSMPECLSYYEDRYPKHEGIFSTLNRDYSFRDYSSECTHSENSRSCENMNGTSYYNSHSHSGEENLNPVPQLDIGTLENVFTAPTSTPSSIQQVNVTDSDEEEEEKVLRDL
Protein: Nicotinate phosphoribosyltransferase (EC 6.3.4.21) (A0A1D8PRI0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- nicotinamidase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Nicotinamide-nucleotide adenylyltransferase
- Ribosylnicotinamide kinase
- NAD
- Purine nucleoside phosphorylase
- Nucleotidase
- Trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase
- IMP-specific 5'-nucleotidase 1
- Nicotinamide-nucleotide adenylyltransferase
Sequence:
MNGTEDKPVIKSFLDTDLYKLFMHAAVNKQFPDVPVKYRYTNRTPQLKLNSQAISWLKKQIEYLGDLRFSAEEILYLHRVLPQLPSDYLEYLADFKLVPSSQIKYLDNDEGDFELEIVGKWNDTILYEIPLLALVSEAYFKFVDTDWNYEGQYALAQKKAKQLISNECNFSEFGTRRRRSYESQEIVIKAIKDVQIDTQSKYIAGTSNVYFAMKYDLPPIGTVAHEWYMGIASITQDYVHANKLAMDYWIDTFGAKYAGLALTDTFGTDNYLTMFVAPYVNEYSGVRQDSGDPELYAEKIARHYEKMGIAKNTKIICFSDSLNVEKCLKYKNTADKLGLISTFGIGTFFTNDFNKLSNGEKSQPMNIVIKIKEANGKPAIKISDNIGKNMGDQATVDRVKQELGYTERTWSEGDETHRWSK
Protein: Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) (P02468)
Organism: Mus musculus (Mouse)
Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.
Interaction partners:
- Laminin subunit beta-1
- Nidogen-1
- Laminin subunit alpha-5
- Laminin subunit alpha-4
- Laminin subunit alpha-2
- Integrin beta-1
- Laminin subunit beta-2
- Laminin subunit alpha-3
- Integrin alpha-6
- Laminin subunit alpha-1
Sequence:
MTGGGRAALALQPRGRLWPLLAVLAAVAGCVRAAMDECADEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQQHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPNSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNEPKVLKSYYYAISDFAVGGRCKCNGHASECVKNEFDKLMCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASESLPCDCNGRSQECYFDPELYRSTGHGGHCTNCRDNTDGAKCERCRENFFRLGNTEACSPCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDLRGSTDECNVETGRCVCKDNVEGFNCERCKPGFFNLESSNPKGCTPCFCFGHSSVCTNAVGYSVYDISSTFQIDEDGWRVEQRDGSEASLEWSSDRQDIAVISDSYFPRYFIAPVKFLGNQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTVKYIFRLHEATDYPWRPALSPFEFQKLLNNLTSIKIRGTYSERTAGYLDDVTLQSARPGPGVPATWVESCTCPVGYGGQFCETCLPGYRRETPSLGPYSPCVLCTCNGHSETCDPETGVCDCRDNTAGPHCEKCSDGYYGDSTLGTSSDCQPCPCPGGSSCAIVPKTKEVVCTHCPTGTAGKRCELCDDGYFGDPLGSNGPVRLCRPCQCNDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKEGFFGNPLAPNPADKCKACACNPYGTVQQQSSCNPVTGQCQCLPHVSGRDCGTCDPGYYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPEGCKPCDCHHEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKAAEHRVKLQELESLIANLGTGDDMVTDQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNSSLHSQISRLQNIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQPESTGEPNNMTLLAEEARRLAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDSEALENEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAAKKGRSTLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASAVQKNATSTKADAERTFGEVTDLDNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASQAAQEAELNARKAKNSVSSLLSQLNNLLDQLGQLDTVDLNKLNEIEGSLNKAKDEMKASDLDRKVSDLESEARKQEAAIMDYNRDIAEIIKDIHNLEDIKKTLPTGCFNTPSIEKP
Protein: 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (Q3TXS7)
Organism: Mus musculus (Mouse)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Interaction partners:
- 26S proteasome regulatory subunit 10B
- 26S proteasome non-ATPase regulatory subunit 12
- 26S proteasome regulatory subunit 7
- 26S proteasome regulatory subunit 6B
- 26S proteasome non-ATPase regulatory subunit 3
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 13
- 26S proteasome regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome non-ATPase regulatory subunit 2
Sequence:
MITSAAGIISLLDEEEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDPMETEEKTASAVAGKTPDASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLSMTETCRYQPFKPLSIGGIIILKDTSEDVEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD
Protein: Amine oxidase domain-containing protein (UDP-galactopyranose mutase (EC 5.4.99.9)) (G5ECS4)
Organism: Caenorhabditis elegans
Interaction partners:
- Fungal lipase-like domain-containing protein
- SSD domain-containing protein
- YitH/HolE acetyltransferase
- Ground-like domain-containing protein
- Apple domain-containing protein
- LiPocalin-Related protein
- Warthog protein 1
- Apple domain-containing protein
- NOmpA Homolog
- SUppressor of Pkc-3
Sequence:
MKIVCIGAAPTALGAAYRLNELKNEGNEAAQNAEIVLLEQEAIAGGLSCTVTDEKGFLWDMGGHITFNHNYPYYEKATQWAVDDWNKLARNCMVDMNYLYDKKGIHLVPYPAQFAVPLFPDEVKNRCLADLKERYENPQDGTTPDNFEEWVLQHFGPTILNTFFKPYTKKVWTVEPLKMSPNWVGSRVAKLPQEKLEELCSMDQAELANADFGWGPNSYFTFPTYGGTGNVWNSMAKKLPNEWFKFNNKVTGVDHKEKTVEILEKGQTEPTKMSYDVLLNTAPIDQLVNNTQITAPLDIVHNKVFIVGVGLRKPMTSFLEKFTWLYFPDREVPFFRVTILSRYGEVTPDGDKYWSVMCECARPIDDPITEEEMVKKTLDGLVIKDMITREAIESVYSITLPYGYPIPTPNRDRELARAHGELERHQIYSRGRFGGWKYEASNQDHCFIQGKEFIDRVILGEPEKLYKTGVPTIPRG
Protein: Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive brain sodium channel 2) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG) (Q62962)
Organism: Rattus norvegicus (Rat)
Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Activation by an extracellular pH drop is followed by a rapid pH-independent inactivation. Heteromeric channel assembly seems to modulate channel properties.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:11842212, ECO:0000269|PubMed:15504740}; Multi-pass membrane protein {ECO:0000269|PubMed:15504740}. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO:0000250|UniProtKB:Q925H0}.
Interaction partners:
- Acid-sensing ion channel 1
- Stomatin like 3
Sequence:
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASLLTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC
Protein: Chitin deacetylase 7 (BmCDA7) (EC 3.5.1.41) (H9JW44)
Organism: Bombyx mori (Silk moth)
Function: Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.
Subcellular location: Secreted {ECO:0000269|PubMed:24473143}.
Interaction partners:
Sequence:
MKLVFYAALLTAVLAKELQLATECDPEACKLPDCRCSSTSIPGGLEPRNTPQFVTLTFDDGVNVINVETYREVLYNRVNSNNCPVRATFYVSHEYTNYQLVNELYNRGHEIALHSISHRTPPSFWAAATYDEIKEEIADQKVQIAHFANIPFEEVKGVRLPFLQMNGNTSFQVMSDFGLTYDCTWPASAQTQRGLWPYTLDYASTQDCTIPPCPTASLPGSWVVPMIAWTDPNGFPCVMVDACTSFPDREDPDAWFRFIVTNFERHYLANRAPFGFFVHEWYISAYPAVKTALVSSSDVVEWVRNPIPIAEYRSRSCKTFRQTACPASSCGPLVAEHNQLSYWLQLCNRCPAKYPWVGNPFGLN
Protein: Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) (Q9NAF9)
Organism: Caenorhabditis elegans
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase
- peptidylprolyl isomerase
- Sex-regulated protein janus-B
- Amidohydrolase-related domain-containing protein
- DNA/RNA-binding protein Kin17 WH-like domain-containing protein
- Mitochondrial chaperone BCS1
- WD repeat-containing protein 48 homolog
Sequence:
MPPKKTPKGGASGSGKDDGGGQKKEAKGGGTAVKVRHILCEKQGKALEAIEKLKSGMKFNEVAAQYSEDKARSGGDLGWMTRGSMVGPFQDAAFALSNSSCDKPIYTDPPVKTKFGYHVIMVEGKK
Protein: Non-race specific disease resistance protein 1-like protein a (D2CFI2)
Organism: Coffea arabica (Arabian coffee)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MSDPSSSAGGCCRCCCSFILTSGLTALFMWLSLRGSKPSCSIEDFYVPSLNATDNSTTTRSNHTLYFDLRFKNEMKDKGVGYDDLNLTFFYVQNGSLGIANYTVPSFYQGHDKKARRKELVQTYGVPWEAAYRAVSNGSTVTFRVGLTTRVRYKILFWYTKRHGLKVGANVDVNNSGKKVNKKGIRLKSGAPESVRCPGLVVISIALYFLVLLL
Protein: Rac GTPase activating protein 1 (F8W0L1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDTMMLNVRNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHELGKYKDLLMKAETERSALDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEEQKSALAFLNRGQPSSSNAG
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) (ADAM-TS15) (ADAMTS-15) (EC 3.4.24.-) (P59384)
Organism: Mus musculus (Mouse)
Function: Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1401-|-1402-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:24220035}. Cell surface {ECO:0000269|PubMed:24220035}.
Interaction partners:
Sequence:
MLLLGISILALAWRPAGSSEPEWEVVVPIRRDPDINGRHYYRRGTEDSGDQGLIFQITAFQQDFYLHLTPDAQFLAPAFATEYLGVPLQRLTGSSLDLRRCFYSGYVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLPNTSAPEAQRHSQGAHLLQRRGAPVGPSGDPTSRCGVASGWNPAILRALDPYKPRRTGAGESHNRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLGDRDTGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPITLPEDLPGTSYSLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKFCLKGACVERHNPNKYRVDGSWAKWEPYGSCSRTCGGGVQLARRQCSNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCTPDSTSVCVQGKCIKAGCDGNLGSKKKFDKCGVCGGDNKSCKRVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSVLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSTRPKDPRGSPVLRNSVLSLSNQVEQPDNRPPARWVAGSWGPCSVSCGSGLQKRAVDCRDSPGQQGASACDVDHRPLEKRACGEPCPTWELGNWSPCSKSCGRGFKRRPLKCVGHGGRLLARDQCDLRRKPQELDFCVLRPC
Protein: Calcineurin B homologous protein 3 (Tescalcin) (TSC) (A0AVX7)
Organism: Gallus gallus (Chicken)
Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:19345287}. Cytoplasm {ECO:0000269|PubMed:19345287}. Membrane {ECO:0000250|UniProtKB:Q96BS2}; Lipid-anchor {ECO:0000250|UniProtKB:Q96BS2}. Cell membrane {ECO:0000250|UniProtKB:Q96BS2}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q96BS2}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9JKL5}. Note=Expressed in both the nucleus and cytoplasm of the embryonic testis. {ECO:0000269|PubMed:19345287}.
Interaction partners:
- Sodium/hydrogen exchanger
- Sodium/hydrogen exchanger
Sequence:
MGSAQSVPPEMRALAERTGFTSEQIEQLHRRFKQLNHNRKTIRKEDFDTIPDLEFNPIRARIVHAFFDKRNLRKAPAGLAEEINFEDFLTIMSYFRPIEMDMDEERLESFRKEKLKFLFHMYDADYDGIITLQEYKNVLDELMSGNPHLEKESLRAIAEGAMLEAASACMARTGPDEVYEGITFEDFLKVWKGIDIETKMHVRFLTMEAIAHCY
Protein: Teashirt homolog 3 (Zinc finger protein 537) (D3ZKB9)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:19343227}. Cell projection, growth cone {ECO:0000269|PubMed:19343227}. Note=Colocalizes with APBB1 in the nucleus (By similarity). Colocalizes with APBB1 in axonal growth cone. {ECO:0000250}.
Interaction partners:
Sequence:
MAAYVSDELKAAALVEDDIEPEEQVADGEPSAKYMCPEKELSKACPSYQNSPAAEFSSHEMDSESHISETSDRMADFESSSIKNEEETKEVQVPLEDTTVSDSLEQMKAVYNNFLSNSYWSNLNLNLHQPSSENNGGGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQNRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPAARKKPSLELELPSSPDSTGGTPKATLSDASDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMKKGKPIMETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASVSPKLTVEIKKEVDKEKAVLDEKPKEKEKASEEEEKYDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNSEIVSPTKTQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKVEEKMKEPDSKLSPPKRATPSPCSSEQSEPIKMEASSGSGFKSQENSPSPPRDVCKEASPSAEPVENGKELVKPLSGGSLSGSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPPLQAKKAEHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSGLLSPTSTSPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNPQHLLILQAQFAASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINNQIAQTKSPSEKMVTSSPEEDLGTTYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLFVSELEKQ
Protein: Trimethylguanosine synthase (Cap-specific guanine-N(2) methyltransferase) (F4HRC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5
- AT3G18790 protein
- Trimethylguanosine synthase
- Zinc finger CCCH domain-containing protein 42
- At1g31870
- Probable small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein E
- Sm protein F
- Small nuclear ribonucleoprotein E
Sequence:
MGKVRGEVEEAEGEAIEALGSLFKLTQIHLWVDTDTPLFHQHSGNKSVDDTYGIANNGLMKEMNDLGLPVSFRTNKQWKNRTRGYQKKGFKDRLDEEVNVILKVEDTLNLVSALNEEVESPCFEEDCVQVIEVEEENHEVVVGSCFLGNGDGDSVLASETIDSHDSSVWKVYWDSFYGRSYFYNFKTQESKWEPPLGMEHLAYSDESHNLSELVIEKHHDDLSGTVLGDDVPFDKADDLGGVCQSQLEAEATEEVNSLIDTYQETSIGNQSLDITSLGEEGTGAYVVSSVRKAKKESRRSRAKKKLLNSYTGTEMKGVPEEYSPILGKYWCQRYLLFSRFDEGIKMDEEGWFSVTPELIAKHHATRCNEGIVIDCFTGVGGNAIQFASRSHYVIAIDLDPKKLDLAKHNAAIYGVADKIDFVKGDFFDLAHNLKAGTVFLSPPWGGPDYLKASTYDMKTMLRPRDGDALFKAAMNIASTIIMFLPRNVDINQLAELALSTSPPWSLEVEKNYLNGKLKAVTAYYVRQDDCKKLKRRPQ
Protein: Acetamidase/Formamidase (Q2U0E3)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- Glutamine synthetase
- Glutamine synthetase
- Glutamine synthetase
- nitrilase
- CN hydrolase domain-containing protein
- CN hydrolase domain-containing protein
- Arylacetonitrilase
- nitrilase
- Glutamate dehydrogenase
- NAD-specific glutamate dehydrogenase
Sequence:
MGHKGIRTALKVDLDKPAWEQPGLHNRWHPDVPSCGKIANNEVVKIECLDWTGGQIKNNDSADDVKNVDLTQIHYLSGPFDIETAEPGDVLLVEIQDVQPFQDQPWGFSGVFHKQNGGGFLDEIYPESAKAIWDFEGIFCSSRHIPHVRFAGLIHPGILGCAPSTEVLAEWNRREGELIAANTTSREVAKPPEPKSAHAGSAEASLKERIAKEGARTIPGRPEHGGNCDIKNLSRGSKVYLPVHVPGAKFSVGDLHFSQGDGEISFCGAIEMAGIITLKFTVMKGGMAKLGMKSPIFHPGPVEPQFGPGRYLTFEGFSVDENGKQHCLDATVAYRQTCLRVIEYLRRYGYSDYQIYLLLSCAPVQGHIAGIVDIPNACTTMGVPMDIFDFDIRPEAEVVKLDMGSCAFARN