wanglab/gogpt-training-data huggingface dataset:
Protein: Germ cell-specific gene 1-like protein (GSG1-like protein) (Q6UXU4)
Organism: Homo sapiens (Human)
Function: As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Synapse {ECO:0000250}.
Interaction partners:
- Protein shisa-9
- Protein cornichon homolog 2
- Protein cornichon homolog 1
- Protein cornichon homolog 4
- Glutamate receptor 1
Sequence:
MKTSRRGRALLAVALNLLALLFATTAFLTTHWCQGTQRVPKPGCGQGGRANCPNSGANATANGTAAPAAAAAAATASGNGPPGGALYSWETGDDRFLFRNFHTGIWYSCEEELSGLGEKCRSFIDLAPASEKGVLWLSVVSEVLYILLLVVGFSLMCLELFHSSNVIDGLKLNAFAAVFTVLSGLLGMVAHMMYTQVFQVTVSLGPEDWRPHSWDYGWSFCLAWGSFTCCMAASVTTLNSYTKTVIEFRHKRKVFEQGYREEPTFIDPEAIKYFRERMEKRDGSEEDFHLDCRHERYPARHQPHMADSWPRSSAQEAPELNRQCWVLGHWV
Protein: L-lactate dehydrogenase (L-LDH) (EC 1.1.1.27) (P00344)
Organism: Geobacillus stearothermophilus (Bacillus stearothermophilus)
Function: Catalyzes the conversion of lactate to pyruvate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00488}.
Interaction partners:
Sequence:
MKNNGGARVVVIGAGFVGASYVFALMNQGIADEIVLIDANESKAIGDAMDFNHGKVFAPKPVDIWHGDYDDCRDADLVVICAGANQKPGETRLDLVDKNIAIFRSIVESVMASGFQGLFLVATNPVDILTYATWKFSGLPHERVIGSGTILDTARFRFLLGEYFSVAPQNVHAYIIGEHGDTELPVWSQAYIGVMPIRKLVESKGEEAQKDLERIFVNVRDAAYQIIEKKGATYYGIAMGLARVTRAILHNENAILTVSAYLDGLYGERDVYIGVPAVINRNGIREVIEIELNDDEKNRFHHSAATLKSVLARAFTR
Protein: Interferon alpha-inducible protein 27-like protein 2 (Interferon-stimulated gene 12b protein) (ISG12(b)) (ISG12B) (Protein TLH29) (pIFI27-like protein) (Q9H2X8)
Organism: Homo sapiens (Human)
Function: Plays a role in the apoptotic process and has a pro-apoptotic activity.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:27673746}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MMKRAAAAAVGGALAVGAVPVVLSAMGFTGAGIAASSIAAKMMSAAAIANGGGVSAGSLVATLQSVGAAGLSTSSNILLASVGSVLGACLGNSPSSSLPAEPEAKEDEARENVPQGEPPKPPLKSEKHEE
Protein: F-box protein pof9 (O74381)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- F-box protein pof13
- F-box protein pof12
- GTP-binding protein ypt1
- Inositol diphosphatase siw14
- F-box protein pof6
- La-related protein 7 homolog
Sequence:
MAKSPFLELSYDILLEISTYLDYKDIVHLSETCKSLSYVFDDKTIWHRFCARVQGLTNVVPVVDDNYKRPYAVWKDRGYAYSWGQQIRNYLGRVVNTNQYPRDRPGALTGKDVRSTIQVQVGGYGMYLLNENGNLYVTGVPNNVGPELMRDLEPIVKIHAGREFCLALGETGHLYQVSLKTRICLTDEQNMLSAYRGRIANFKSGWDSHSAYVPGIGFLVWHTGRESEAQLFQPEASMKEFVLNDYVHCAGFLVYTVASPQKKGAVFRLDLDQATQHTLGRELKRFASHDPHQGWHLAGSFETFTCLSDDGNTVYMGHANTKQVDDDPVIHDFLQNRGIKQLAHGDHHHLYLTSDHSIWSWGVELRYCGCLGLGSLHLQEQTSDPSIVSDPRTARNIVSIPHQIHFSGTCYSVAAGGWQSAALAISESVLPEVNVPPITTFSIIRPSRVPALRFLAAPATRTLERDG
Protein: Cell cycle control protein (G3HH32)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004250}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Phospholipid-transporting ATPase
- Putative phospholipid-transporting ATPase IH
- Phospholipid-transporting ATPase
Sequence:
MAMNYNAKDEVDGGPPCPPGGAAKTRRPDNTAFKQQRLPAWQPILTAGTVLPTFFIIGLIFIPIGIGIFVTSNNIREIEIDYTGTEPSSPCNKCLSPNVTSCVCTINFTLEQSFEGNVFMYYGLSNFYQNHRRYVKSRDDSQLNGDPSALLNPSKECEPYRRDEDKPIAPCGAIANSMFNDTLELFLVANESDPIPMPIPLKRKGIAWWTDKNVKFRNPPGKESLMEKFKETTKPVNWHKPVYMLDPDEDNNGFINEDFIVWMRTAALPTFRKLYRLIERRNDLHPTLPAGQYYLNITYNYPVHSFDGRKRMILSTISWMGGKNPFLGIAYITIGSISFLLGVVLLVINHKYRNSGNTADITI
Protein: Odorant receptor 46a, isoform B (Q9V3N2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Putative odorant receptor 85d
- Odorant receptor 33c
- Putative odorant receptor 59c
- Putative odorant receptor 85e
- Putative odorant receptor 69a, isoform A
- Gustatory and odorant receptor 21a
Sequence:
MVTEDFYKYQVWYFQILGVWQLPTWAADHQRRFQSMRFGFILVILFIMLLLFSFEMLNNISQVREILKVFFMFATEISCMAKLLHLKLKSRKLAGLVDAMLSPEFGVKSEQEMQMLELDRVAVVRMRNSYGIMSLGAASLILIVPCFDNFGELPLAMLEVCSIEGWICYWSQYLFHSICLLPTCVLNITYDSVAYSLLCFLKVQLQMLVLRLEKLGPVIEPQDNEKIAMELRECAAYYNRIVRFKDLVELFIKGPGSVQLMCSVLVLVSNLYDMSTMSIANGDAIFMLKTCIYQLVMLWQIFIICYASNEVTVQSSRLCHSIYSSQWTGWNRANRRIVLLMMQRFNSPMLLSTFNPTFAFSLEAFGSIVNCSYSYFALLKRVNS
Protein: Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) (P24329)
Organism: Rattus norvegicus (Rat)
Function: Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Involved in the formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Sulfite oxidase, mitochondrial
- Cystathionine gamma-lyase
- Ethylmalonic encephalopathy 1
- Adenylyltransferase and sulfurtransferase MOCS3
- Cysteine desulfurase
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Sulfide:quinone oxidoreductase, mitochondrial
- 3-mercaptopyruvate sulfurtransferase
- Kynurenine--oxoglutarate transaminase 1
Sequence:
MVHQVLYRALVSTKWLAESIRSGKVGPSLRVLDASWYSPGTRQARKEYQERHVPGASFFDIEECRDTTSPYEMMLPSEAHFGDYVGNLGISNDTHVVVYDGDDLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLNRSLLKTYEQVLENLQSKRFQLVDSRAQGRYLGTQPEPDAVGLDSGHIRGSVNVPFMNFLTEDGFEKSPEELRAIFQDKKVDLSQPLIATCRKGVTACHIALAAYLCGKPDVAVYDGSWSEWFRRAPPETRVSQGKSGKA
Protein: Protein JSN1 (Pumilio homology domain family member 1) (P47135)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Pumilio homology domain family member 6
- Heterogeneous nuclear rnp K-like protein 2
- Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
- RNA-binding protein MRN1
- Protein SCP160
Sequence:
MDKSKQMNINNLSNIPEVIDPGITIPIYEEEYENNGESNSQLQQQPQKLGSYRSRAGKFSNTLSNLLPSISAKLHHSKKNSHGKNGAEFSSSNNSSQSTVASKTPRASPSRSKMMESSIDGVTMDRPGSLTPPQDMEKLVHFPDSSNNFLIPAPRGSSDSFNLPHQISRTRNNTMSSQITSISSIAPKPRTSSGIWSSNASANDPMQQHLLQQLQPTTSNNTTNSNTLNDYSTKTAYFDNMVSTSGSQMADNKMNTNNLAIPNSVWSNTRQRSQSNASSIYTDAPLYEQPARASISSHYTIPTQESPLIADEIDPQSINWVTMDPTVPSINQISNLLPTNTISISNVFPLQHQQPQLNNAINLTSTSLATLCSKYGEVISARTLRNLNMALVEFSSVESAVKALDSLQGKEVSMIGAPSKISFAKILPMHQQPPQFLLNSQGLPLGLENNNLQPQPLLQEQLFNGAVTFQQQGNVSIPVFNQQSQQSQHQNHSSGSAGFSNVLHGYNNNNSMHGNNNNSANEKEQCPFPLPPPNVNEKEDLLREIIELFEANSDEYQINSLIKKSLNHKGTSDTQNFGPLPEPLSGREFDPPKLRELRKSIDSNAFSDLEIEQLAIAMLDELPELSSDYLGNTIVQKLFEHSSDIIKDIMLRKTSKYLTSMGVHKNGTWACQKMITMAHTPRQIMQVTQGVKDYCTPLINDQFGNYVIQCVLKFGFPWNQFIFESIIANFWVIVQNRYGARAVRACLEAHDIVTPEQSIVLSAMIVTYAEYLSTNSNGALLVTWFLDTSVLPNRHSILAPRLTKRIVELCGHRLASLTILKVLNYRGDDNARKIILDSLFGNVNAHDSSPPKELTKLLCETNYGPTFVHKVLAMPLLEDDLRAHIIKQVRKVLTDSTQIQPSRRLLEEVGLASPSSTHNKTKQQQQQHHNSSISHMFATPDTSGQHMRGLSVSSVKSGGSKHTTMNTTTTNGSSASTLSPGQPLNANSNSSMGYFSYPGVFPVSGFSGNASNGYAMNNDDLSSQFDMLNFNNGTRLSLPQLSLTNHNNTTMELVNNVGSSQPHTNNNNNNNNTNYNDDNTVFETLTLHSAN
Protein: Alpha-D-kanosaminyltransferase (EC 2.4.1.301) (2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase) (Glycosyltransferase KanE) (Kanamycin biosynthesis protein E) (Q65CC7)
Organism: Streptomyces kanamyceticus
Function: Glycosyltransferase involved in the biosynthesis of kanamycins by catalyzing the transfer of the hexose kanosamine from UDP-alpha-D-kanosamine to disaccharide precursors. Can also use UDP-alpha-D-glucose as sugar donor with much lower efficiency.
Interaction partners:
Sequence:
MHLLVRALVEEMAGRGVPHRVLTMSPPKVPKDIRIGQRIKVHARRLPVLPIPSDLEGYFGLVGAWAKGSLLWVLRNRKRLRREIGARVHAHCDGSGAAAFYPYLMSRILGVPLVVQIHSSRYLSQHPTTLFERVTDPIAKWAERHAVRKAAAVLMLTDRARDEMRRKAQLPAERVHRLAYLASDQFKDADTEARRAELRERYGLDDRPIVLYVGRIAAEKGVEYYIEAAAELTRRGRDCQFVIAGDGPARPDLEKLIGARGLRDRVTITGFMSHEFIPSMISLGELVVLPSRYEELGIVILECMTMRRPLVAHDVNGVNKLIEDGTTGIVVPPFRTPEMADAVERLLDDPELRERMAENAAPLPAAKYSLSAAGDQLAGIYREIGL
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (B2LYR7)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
- Superoxide dismutase copper chaperone
- Superoxide dismutase copper chaperone
- Protein DJ-1 homolog C-like isoform X1
- Protein DJ-1 homolog D-like
- Protein DJ-1 homolog B-like
- Protein DJ-1 homolog B-like
- Protein DJ-1 homolog B-like
- Protein DJ-1 homolog B-like
- DJ-1 protein homolog E-like
- Protein DJ-1 homolog D-like
Sequence:
MAAHIFTTTPSHLALSFPSSTNPSNPPVLLSSFRGVSLKLPRQSLSLAATIPKKPFSVFAVTKKAVAVLKGNSEVEGVVTLTQENDGPTTVNVRITGLTPGPHGFHLHEYGDTTNGCMSTGAHFNPNNMTHGAPEDEVRHAGDLGNIIANADGVAEATIVDNQIPLSGPNAVVGRAFVVHELEDDLGKGGHELSLTTGNAGGRLACGVVGLTPV
Protein: At1g80210/F18B13_28 (Mov34/MPN/PAD-1 family protein) (Q8RW94)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- Proteasome subunit alpha type-3
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- BRISC and BRCA1-A complex member 1
- Proteasome subunit beta type-1
- 26S proteasome regulatory subunit RPN13
- Proteasome subunit beta type-4
- Proteasome subunit beta type-6
- 26S proteasome regulatory subunit 6B homolog
Sequence:
MSLTCVNMSEDVWLTCLTHALSTETEEIMGLLLGDIEYSKDGGSATAMIWGASPQSRSDRQKDRVETNPEQLAAASAQADRMTISTGRTTRVIGWYHSHPHITVLPSHVDVRTQAMYQLLDSGFIGLIFSCFSEDANKVGRIQVIAFQSSDGKPNSIPKSMSLVLANKDSVIDLESSFSSSDSIYQRSSSARGDNPELDTSDTATTSGSKGGGRVSDFEAFFVNNTEANNTRRDGTSGNYSSTAIEIDSMDMSESMQEAMHRSNLETSGVGYVRKEVPLHVLPTSSLLQLNSPLASFKSLQRVLYEEERAAYHQSVQQSKRDGRVHPLAFIHNTSTYQASMCKLIEYCLSPAINALQDRLKENKIRLAMLMDEAEVLEAQKLKGAETSGGASRLVHGSGSRSRRRS
Protein: Kelch-like protein diablo (Q9VUU5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.
Interaction partners:
- Cullin 3, isoform F
- m7GpppN-mRNA hydrolase
- RING-box protein 1A
- Nedd8-conjugating enzyme UbcE2M
Sequence:
MGDLPGSGSTAQPRDAAVTGTGGNSTAGGGSSVGSTAVDRPPSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVMRAPQTENYMWCENSFKQPNS
Protein: Heavy metal-associated isoprenylated plant protein 22 (AtHIP22) (AtHIPP22) (Farnesylated protein 7) (AtFP7) (Q93VP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Heavy-metal-binding protein. Binds cadmium. May be involved in cadmium transport and play a role in cadmium detoxification.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9SZN7}.
Interaction partners:
- Myb domain protein 49
- At2g28660
- Transcription factor bHLH101
- Berberine bridge enzyme-like 16
- Transcription factor ORG2
- Heavy metal-associated isoprenylated plant protein 3
- Heavy metal-associated isoprenylated plant protein 6
Sequence:
MGALNYLSEYFSNHFYVSIRKRKKRKVMQTVNIKVKIDCDGCERKIKNAVSSIKGAKSVEVNRKMHKVTVSGYVDPKKVLKTVQSTGKKKAELWPYVPYTMVAYPYAAGAYDKRAPPGFVRKSEQAQAQPGSTDDKLMSLFSDENPNACTVM
Protein: IP10416p (Serpin 53F) (Q4V3G2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Male accessory gland protein
- GH21475p
- Serpin 77Bb
- Serpin 28Db
- Serpin 85F
Sequence:
MYVLLLILLGISRYRAQKNSQLPDELYAAIVNSFSNRNIMFSTEMIRSSMLFIYVGVEEDESEQIRKAMHYRGTHLSEYKPKTQKIFAMSVKKAPVAKSLTRFYVRQNMKMSTEYRVFMRHTEGRARNIAFAREQLDEVNTFYSHEMGEQIGQVVKESWWKPNSQGLLVNAIFFNLSWERTFNPEATYPREFRVNATKSVMIPMMHEDSKFAFGILGNLKATAVLVPFSHGDLRMLLIKPDQPDGLAALQMKLQAMNILSVARNLTMMDVFVGIPKFKIHSDLELSPAFEKMGIKDIFKPSKSFSTLLHRNTNFRIDGVIHVVTFEFQEQGIGTPSTDVGNGSLTHTFNGVKYFLATHPFAFYIIDNTSIYFAGHVTSF
Protein: Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) (P61089)
Organism: Mus musculus (Mouse)
Function: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production. UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P61088}. Cytoplasm {ECO:0000250|UniProtKB:P61088}.
Interaction partners:
- Ubiquitin thioesterase OTUB1
- E3 ubiquitin-protein ligase RNF8
- Ubiquitin-conjugating enzyme E2 variant 2
- Ubiquitin-conjugating enzyme E2 variant 1
- Mitogen-activated protein kinase kinase kinase 7
- TNF receptor-associated factor 6
- Predicted gene 20431
- Toll-like receptor 4
- E3 ubiquitin-protein ligase CHIP
- Baculoviral IAP repeat-containing protein 2
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
Protein: Uncharacterized protein (Q38AU9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Telomerase-associated protein, putative
Sequence:
MRAAKEPPLPEDIRVRLDNLNGGSTADEWKAVGNDCFSRGFYLSAIRCYTKALDLDSSSAAVYSNRSAAYLKSTMFAGPALALKDAEHAVRLDPGWYKAHLRVADAQFGRKKYEEAKAAYQKVLELNNSCVAAKDSLKLVEQELFLQFLDDQKKKERKDELNGGDQDGVSKGDSFSWSHNTTGSGNNVTASPTPSNDRAQVEVSESEVERHIRLWTQDTVLREDRTGMRAFGATIDEADREAGVEYKKNLLSKFRNRLETDEPLRSNVERRLDRQMRLGENVDYRNPEKHRAILMRGTDGVGLGISTDAYKSYKYESTMW
Protein: Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Egg-laying defective protein 45) (Eukaryotic translation initiation factor 3 subunit 10) (P34339)
Organism: Caenorhabditis elegans
Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 30 kDa subunit
- COP9/Signalosome and eIF3 complex-shared subunit 1
- Eukaryotic translation initiation factor 3 subunit E
Sequence:
MAPNYFQKPEAALKRAEELIQVGKESDALDTLHDTIKARRHKQWTTVHEQIMIKHMELCVDLKKQHLAKDALFQYKALTQQINVKSLETVVVHFLKLAEQRTEDAQKQSIEKVEEIGDLDQGDVPERLLLAVVSGAAAQDRMDRTVLAPWLRFLWDSYRNCLELLRNNAQVEQLYHTISRHSFTFCLRYQRRTEFRKLCDLLRMHLNQIQKHQYAPNVNSFRVKLTSPESLGLMQDTRLIQLDTAIQMELWQEAYKSAEDVHGMMQLSKDKDKRTVKPASYVNYYDKLALVFWKAGNSLFHAAALLQKFIIYKDMKKSFTQDEAQEQATRVLLATLSIPEGSDSPSDLSRNLDIEDQHVANMRLLSNLLRLPIAPTKNGILKEAARIGVPEAAGQTAKDLYKLLESNFSPLKVAKDVQSVLDTVTRPDHLQYVESLQAVAAVKALKQVSVIYEAISWERIRKIIPFYSDLALERLVVEASKHRIVKAQLDHRADCVRFGSSDATLAGGVDECDNNEGFTGDDTQLGVEGVRNHLEAMYTRLRGLVEGLDAEKRRKEILKKIEGQVTSYEKNRPTEIERIHRRKKMLENYKENWERVKAEKTAAAATEQAKREEAARAEEMKRLDEQNKESERKRKQAEQDEIQKKIKQDQLYKMQQNAIYQEIIKEKGLEQFRDMDPEQVLREQRERLDKERAETQRRLQQQEKNFDHHVRALHLEELNERRAVMNMRLSEAPKLHDLYEEARIAKEIAAHDSHVKLWGMWDQVRDATFDWVESVKIDNQETLEKKLSDWQAKLEAVRNNRLAERAEDRKKKRKEDAIQAKIAEERKKREEEERARLQVIEGQRRQHNDGRGRREMENSVAMQDNDWRRNPPRESLPPRETRPMRDGPTREPREFRGDRDREPREPFREVPSSKADTDNSWRSSAQPTRKPDDRRSDEFRRNDDVRRNDDVRRNDPPRPASKADTGDKWERGVKPVVSPPKTDAPSVSEPKSEGPKRFVPPHLRNRQGGGGAGGSEEQSAPARSGNSNVTSPPDRAQGLRGPPPTGRNSLPRRDGPPPRSNNTGNTGNADSGSWRK
Protein: Mdg1p (A0A1D8PFV7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Protein SDS23
- 5'-AMP-activated protein kinase subunit gamma
- Ribosome-associated protein STM1
- RRM domain-containing protein
Sequence:
MSLHYTFKWPKGPEDVIVTGTFDNWSKSLPLVKQTDGSFSLQVPLPPKAEDVIYKYVVDGEWRINSDENITKDESGIENNIISKDHLKELIAVPGSLIPESGLPVTTPTAQPVSDNQDTLKTTVLPKEEPHHPSLAGEPGIVIPKEKDALSAFEKVEDADAKALNKNVTEVGTANAEAQTGSDNQDTLKTTVLPKEEPHHPSLAGEPGIVIPKEKDALSAFEKVEDADAKALNKNVTEVGTANAEPDSLVAVPSTGVLVEGSELTPEERKKQKKKVKKSQYKARKKQRAAEAAAGEANSTSDIDTEEATPEPTTQAEENNHSKAAAVGLAAAGTGGAAAATIAATTALADHPDTLGSTTNGGHITSKDPVQPPIYEPQTSIEKPKDSVTEPKLDSKLKTTGLPESKIDDNIVSTGPEKSLDQTVDSVAMPKEPESDIKETTTAPVPVPVPIEETKAEPVVDQTTAAPIPVQETETEPEPVVATSKDVAPADYANEPIDTTEEHPKTLDPNAVVPDSEAKEVDASPVVKESRNTHETAQDEEEIIIAAEGSEKDITAAVEAREGAGVTLEEIQPTQSEKERLTREAKLAAGVDGPVTVEKINVPEDELKSQKAESSTKEVSPTTKKAEPERKNTVKKTTTNGKTEEKKKGSFRRFLKKIFN
Protein: 10 kDa chaperonin 2, chloroplastic (Chloroplast chaperonin 10) (Chl-Cpn10) (O80504)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as co-chaperone for protein folding in chloroplasts.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:11402030}.
Interaction partners:
- Chaperonin CPN60, mitochondrial
- Chaperonin 60 subunit beta 1, chloroplastic
- Chaperonin 60 subunit alpha 2, chloroplastic
- Chaperonin 60 subunit beta 4, chloroplastic
- Chaperonin 60 subunit alpha 1, chloroplastic
- Chaperonin 60 subunit beta 3, chloroplastic
- Chaperonin 60 subunit beta 2, chloroplastic
- Heat shock 70 kDa protein 4
- GrpE protein homolog
- Peptidyl-prolyl cis-trans isomerase
Sequence:
MASTFVCSLPNPFFAFPVKATTPSTANHTLLGSRRGCLRIKAISTKWEPTKVVPQADRVLVRLEDLPIKSSGGVLLPKAAVKFERYLTGEIISVGSEVGQQVGPGKRVLFSDVSAYEVDLGTDARHCFCKESDLLALVE
Protein: PRP4 pre-mRNA-processing factor 4 homolog (yeast) (U4/U6 small nuclear ribonucleoprotein Prp4) (Q6PH45)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
- Pre-mRNA-processing factor 8.
- U4/U6 small nuclear ribonucleoprotein Prp31
- Pre-mRNA-processing factor 6
- Activating signal cointegrator 1 complex subunit 3
- PRP3 pre-mRNA-processing factor 3 homolog
- U6 snRNA-associated Sm-like protein LSm7
- Elongation factor Tu GTP-binding domain-containing 2.
- Spliceosome-associated factor 1, recruiter of U4/U6.U5 tri-snRNP
- Peptidyl-prolyl cis-trans isomerase
- U6 snRNA-associated Sm-like protein LSm8
Sequence:
MSDEDEAPVVKRSRIFYGSLEEKEKERLSREGTSTTAKDAVKAGIEAGHINISSGESMEMEERVSERQAEVLAEFERRKRARQITVSTDDVEVKACLRALGEPITLFGEGPAERRERLRNVLSVLGPDALKKSKKEDEKAKRTHEEYQQTWYHEGPTSLKEARLWLAKYSLPRAVKRLDAARAQKEIPESTRTIKQQELHKNLRNVNNFCSQIGDDRPISYCQFSPNSKLLVTASWSGLCKLWKVPDCTLIRTLRGHNTNVGAISFHPQATLTLEESDVNMASCAADGSVKLWSLDSDEPIADIEGHSMRVARVTWHPSGRFLGTTCYDHSWRLWDLEVQEEILHQEGHSKGVHDLHFHPDGSLAGTGGLDSFARVWDLRTGRCVMFLEGHIKEIYSINFSPNGFHVATGSGDNACKVWDLRQRRCIYTIPAHQNLVSSVKFQPNDGHYLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGVDLSPDGQLIATCSYDRTFKLWMSE
Protein: Fibroblast growth factor 3 (FGF-3) (Heparin-binding growth factor 3) (HBGF-3) (Proto-oncogene Int-2) (P05524)
Organism: Mus musculus (Mouse)
Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development (By similarity).
Subcellular location: [Isoform 1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum. Golgi apparatus.
Interaction partners:
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor 3
- Klotho
- Pro-epidermal growth factor
- Vascular endothelial growth factor receptor 2
- Decorin
- Beta-klotho
- Vascular endothelial growth factor receptor 3
Sequence:
MGLIWLLLLSLLEPSWPTTGPGTRLRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQLHPSGRVNGSLENSAYSILEITAVEVGVVAIKGLFSGRYLAMNKRGRLYASDHYNAECEFVERIHELGYNTYASRLYRTGSSGPGAQRQPGAQRPWYVSVNGKGRPRRGFKTRRTQKSSLFLPRVLGHKDHEMVRLLQSSQPRAPGEGSQPRQRRQKKQSPGDHGKMETLSTRATPSTQLHTGGLAVA
Protein: Probable proton/glutamate-aspartate symporter (Q88RJ2)
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Subcellular location: Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02063}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_02063}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Choline/carnitine/betaine transporter
- Protein-export membrane protein SecF
Sequence:
MKKAKLSLAWQIVIGLVLGVAIGALLNHFSAEKAWWISNVLQPAGDIFIRLIKMIVVPIVISSLIVGIAGVGDAKKLGSIGLKTIIYFEVVTTIAIVVGLVLANLFHPGAGIDMSTLGTVDISKYQATAAEVQHEHAFIETLLNLIPSNIFAALMRGEMLPIIFFSVMFGLGLSSLQAELRDPLVRTFQAVSETMFKVTHMIMNYAPIGVFALIAVTVANFGFSSLLPLAKLVVLVYFAIAFFAFMVLGLVARLFGFSVIKIMRIMKDELILAYSTSSSETVLPRVIEKMEKYGAPKSICSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSWSQQLLLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRIMDMARTALNVVGNALAALVIARWEGMYDAVKGEQYYASLMAEKQGAVVVGETAKR
Protein: Stress-activated protein kinase JNK (EC 2.7.11.24) (A0A0R4I9H8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU368052}.
Interaction partners:
Sequence:
MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDCLFPADSEHNKLKASQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHSIDEWKELIYKEVMNFEERTKNGVVKGQPSPSAQVQP