wanglab/gogpt-training-data huggingface dataset:
Protein: TIL domain-containing protein (Q9U1T5)
Organism: Caenorhabditis elegans
Interaction partners:
- Uncharacterized protein
- Peptidase M14 carboxypeptidase A domain-containing protein
- F-box associated domain-containing protein
Sequence:
MQYIVLLSVLLIGANAQLSATRDQECKENESFQTCGTACEPTCGLPTPTFCTLQCVMGCQCNSGFFRRTSDNRCVEQKDCNVAANETIPIPPPATNLTCPVNEVSNECHNPCTEKKCPQKNAPQVNCLMACQVGCSCMDGFVRNNQGVCVKEAECPAIGSQTCGTNEEPNQCHNACFEKKCPVKPQPLVNCMEKCDIGCSCKKGFLRNRQGQCVNPTECPATGSTLTCSKNEEPNDCHNSCSEAKCPVNPQPFVRCMMRCEKACSCKKGLVRNRQGQCVKLAECPPTGSTDENPCNLVDCRTGHQCSMSTGKPTCVPDYSDTPSPLFPGNGSDINIQITPCSTMKCSAGTECMEVQKNCTEPPCGFQGVCVNTTEVPVGGCATMRCSAGTTCQEALVKCAKAPCPSHAACIPNSNETLSSCAAVTCPVGEICTETLVQCFVEPCPPLVSCTPINSTVINSTTTSDSGCASVSCPVGERCEETTMACLMAPCPKAVSCVPMNGNQNSTARQGCDVVRCRANEVCEEQKVDCVKAPCPMQVACVSIVHLNSTTPAPGSTCAKNQTMSDCLNTCSEDKCPGMSKSMMCTKHCGQGCACASGYLRSSDGECYKPKDCPPECGQNEEYRCEKCAGTCKNPEPNCPGPKNKSCKRACICAPGFVKKNGKCVTLASCPDHDHTNITCLGTQEYTDCMPKCQQLCSGAQQCETGMEIAMCTPGCVCRPNYKLDSNGDCVHNRHCFKTTECPDNEEWSKCLSNDNQCDLASISMIANKDQCFSGCVCADGFARNNNGTCVASDKC
Protein: Actin-binding protein (A0A1D8PU03)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Vrp1p
- Actin-related protein 2
- Regulator of cytoskeleton and endocytosis RVS167
- Actin-related protein 3
- Protein BZZ1
- Myosin-5
- Actin
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit
Sequence:
MGILTTQDKEKVKRAIPKANNKIIDATVARLYIAYPDPTKWAYTGLVGAIALVDDLVGHTFFLKLVDIIGHRGVVWDQELYVNFEYNQDRKYFHTFEIEECFVGLLFEDTNDATHFYKRVTTRQKYGSSATVKNKSAIALKERIGSNKSYEIPGPRGEFMDVNTAQRQRRAKGVLYYDDVPPPEWRSLYAELEAAGITEDMIADNRQFIKDYISQQGGPLVGLEPPIPRKFQRKHEIEHSMAIAEPLTVSISSSSSNTTSKHKKAPPPPPPPPPSGPTSQQQQQQQQQSTTVDHHYPSNESKEPSYSPSPSPTSTSTSTPEPESHEITPAKPRFRLPPSTAIAPPVRNTSLPPNGPQFIDKPLPKVPLPLSPVSPQAPNHAYPTTTNTNTNTNTPFNHSVHQVPPPPPARATPPAPPPRARTNQLGLPPRNTPGLPPRTNNTQPPPAPPPRASRGAVPPPPPPPPRATRAPMQLQLQSSPQSSPISPPAQQQQQQQYPSIPPRENTSAIISSPPPAPPLPQQPRPTIATPQQQQQQLPQATTSSVASPAPPLPPQMNQTTQQTPATTTTTTTTTTPSIPAPPPPPPAPPMPDMSNDTSTSANTGGGISEATGDAGRDALLASIRGAGIGVLKKTDKSQLEKPSILLQEAKGETPQINSNTGTSSNAPPATLADAPPATLADAPPATLADALASALNKRKEKVAQSDDEEDDDW
Protein: Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2) (Q9NX18)
Organism: Homo sapiens (Human)
Function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
Subcellular location: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000269|PubMed:19628817}.
Interaction partners:
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase assembly factor 1, mitochondrial
- Succinate dehydrogenase assembly factor 4, mitochondrial
- Transmembrane protein 127
- Succinate dehydrogenase assembly factor 3, mitochondrial
Sequence:
MAVSTVFSTSSLMLALSRHSLLSPLLSVTSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEIFENEVMALLRDFAKNKNKEQRLRAPDLEYLFEKPR
Protein: Probable xyloglucan endotransglucosylase/hydrolase protein 21 (At-XTH21) (XTH-21) (EC 2.4.1.207) (Q9ZV40)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity).
Subcellular location: Secreted, cell wall {ECO:0000305}. Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Protein FLX-like 4
Sequence:
MVSSTLLVMSISLFLGLSILLVVHGKDFNQDIDITWGDGRGNILNNGTLLNLGLDQSSGSGFQSKAEYLYGKVDMQIKLVPGNSAGTVTTFYLKSQGLTWDEIDFEFLGNVSGDPYIVHTNVYTQGKGDREQQFYLWFDPTAAFHNYSILWNPSHIVFYIDGKPIREFKNLEVLGVAYPKNQPMRMYGSLWNADDWATRGGLVKTNWSQGPFVASFMNYNSENACVWSIVNGTTTTSPCSPGDSTSSSSSSTSEWFSQRGMDSSSKKVLRWVQRKFMVYNYCKDKKRFSNGLPVECTAKNKNTKS
Protein: Complexin-4 (Complexin IV) (CPX IV) (Q7Z7G2)
Organism: Homo sapiens (Human)
Function: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity).
Subcellular location: Synapse {ECO:0000250|UniProtKB:Q80WM3}. Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q80WM3}. Note=Enriched at the synaptic terminal. {ECO:0000250|UniProtKB:Q80WM3}.
Interaction partners:
- Complexin-1
- Complexin-2
- Vesicle-associated membrane protein 1
- Complexin-3
- Syntaxin-1A
- Synaptosomal-associated protein 25
- Protein ERGIC-53
Sequence:
MAFLMKSMISNQVKNLGFGGGSEENKEEGGASDPAAAQGMTREEYEEYQKQMIEEKMERDAAFTQKKAERACLRVHLREKYRLPKSEMDENQIQMAGDDVDLPEDLRKMVDEDQEEEEDKDSILGQIQNLQNMDLDTIKEKAQATFTEIKQTAEQKCSVM
Protein: Uncharacterized protein (Q581S6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MELRCFLAHISSRPNEHHVDFPFPLSAAKAPVLGRHSPELYWHLGNNPRCSRRVMTFAVEASEKETFDSADVHHAAATPIHPQVAYCLVLTCVGENPLTVVRRETVGNCSSLQAVEESRTTVLCRNESTILRVGDKVGIMNRVWMQVVLARICVSETVKGPPVVQEADEGTQCYLPPGESECIVPLPTIYTNVPWKRLRHPVRSRLIGAAARQQQRVVTVRCSPILAALPNTQAPLALNGSLNASMDVLSIEHEGESEAAANACASGTRTSGSGGRVSPRVHPRMECDSASTAVTNTDRKWGTCSTFLGDSLDEKSLLNSLDEVHLKRRRMSLGDGSIMDNRSTTSVPDTNSYMDTLDERLNEELCRLEKRTADAEQLISGRSMAVLGGSPPGHANETTERKVGVSIATTVSRDQLQMSSRLSGRNHGLSGAIVRRPVPADSQVVYYRH
Protein: RE47308p (Rbp1-like, isoform A) (Rbp1-like, isoform C) (Q9VYD8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPRYREWDLACKVYVGNLGSSASKYEIENAFSKYGPLRNVWVARNPPGFAFVEFEDRRDAEDATRGLDGTRCCGTRIRVEMSSGRSREGRGGGGGGGGGGGGSGGGGRGGGSGARAGGGGRAGDGGGRYRSRSPRRSRTRSRSFSRDRRSRSDSRDRH
Protein: Apolipoprotein F (Apo-F) (Leukemia virus-inactivating factor) (LVIF) (Q91V80)
Organism: Mus musculus (Mouse)
Function: Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q13790}.
Interaction partners:
- Apolipoprotein A-II
- Beta-2-glycoprotein 1
- Apolipoprotein M
- Apolipoprotein C-IV
- Serum paraoxonase/arylesterase 1
- Clusterin
- Phospholipid transfer protein
- Apolipoprotein C-III
- Apolipoprotein A-I
- Apolipoprotein E
Sequence:
MHSLRLILMSIQLLCYLLLCPVDATSHGEATSVSTVLPPSKLGYQMQTSDKPLSCQMLLPKSLPGFTYMPPVSKFLVGLALRNALEAAGCQAEVWALQLQLYRLGGVEATQALIHHLQELQKSGHTDREVSVDALSSALQLLAWEQPGPKRAKRSISNTDCDNDQEQSVHNVVDLLPAVGTYYNLGTALYYAIKNCSDKAKERGRDGAIDLGYDLLMAMVGASGGPAGAVITAALKPAMKAGVQRLIQYYYDEKEVTTPQPEVTTHQPETGKDATTDIGVVEEIAMSNFVSEVESTTSNWEWPLLKNYGVLAYKR
Protein: Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) (Q9HCG8)
Organism: Homo sapiens (Human)
Function: Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
Subcellular location: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106}. Nucleus speckle {ECO:0000269|PubMed:22961380}. Note=Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins. {ECO:0000269|PubMed:22961380}.
Interaction partners:
- E3 ubiquitin-protein ligase RNF113A
- Eukaryotic initiation factor 4A-III
- Pre-mRNA-processing-splicing factor 8
- Crooked neck-like protein 1
- Pre-mRNA-processing factor 17
- 116 kDa U5 small nuclear ribonucleoprotein component
- Spliceosome-associated protein CWC27 homolog
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-processing factor 19
- U5 small nuclear ribonucleoprotein 200 kDa helicase
Sequence:
MKSSVAQIKPSSGHDRRENLNSYQRNSSPEDRYEEQERSPRDRDYFDYSRSDYEHSRRGRSYDSSMESRNRDREKRRERERDTDRKRSRKSPSPGRRNPETSVTQSSSAQDEPATKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDTDSNTDQDAGSSEEDEEEEEEEGEEDEEGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPDVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRIKDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQK
Protein: Zinc finger protein syd-9 (Synapse defective protein 9) (A0A5E4M3Q4)
Organism: Caenorhabditis elegans
Function: Plays a role in regulating synaptic function, probably by modulation of endocytosis. May be dispensable in muscle for normal locomotion. May be involved in post-transcriptional mRNA processing, in parallel with unc-75.
Subcellular location: Nucleus {ECO:0000269|PubMed:16803962}. Nucleus speckle {ECO:0000269|PubMed:16803962}.
Interaction partners:
Sequence:
MSVCVSPLVQATILMTEESLTCPQCPKSFSSTKLLQQHQQMFHTDKSVLLSLKSTDAPVGMDRAFICETCGKAFRFRSNLAEHRSVHTALKPYVCKFCGKSSRLKGNLTKHILKHHKKEQNEAIAKDDIIVKKAPKIVTKDNGPTTNGSTPTTSTATPSVITVSSALASSNGHNNNNNNHAVNNNLRTIKMELEDPDYNLIAKSAPTPVVSKIVATHTVTPRSRPTPKDIKEILETIAPSVGVSETPEEMCLLPKDASSESDRSVLISLGFDFGSTLSLNHQQLQQVVRELKGELSISPDTVQSDHSDDFEQDSPPPMAIANISTVGGEATLAAMIVAATNASGQRGDGTPDSTDTQKGCSPQRELSPESDPSTSSGDSCPSPPKMLHCKECGTLVRKSSHLPIHMTMSHGYPPPLVAAPVEEKPAPEQPVNASSLHNELRVISNAICELKAQQAATPRVEQALTYIDSRVGKLERSLETALNSIYTLVQLQTGMTSSVNRLREDSTKNFSDLKTRMEMSLSPIKPFQQRFSRERSSSSSVERSPSRERSRSPL
Protein: Protein kinase A (Q56921)
Organism: Yersinia enterocolitica
Interaction partners:
Sequence:
MKIMGTMSPSISLAKAHERISKHWQNPVGELNIEGKRYRIIDNQVVRLNPHSGFSLFREGVGKIFSGKMFSFSIARNLTDTLHAAQKTTSQELRSDIPNALSNLFGAKPQTELPLGWKGKPLSGAPDLEGMRVAETDKFAEGESHISIIETKDKQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRKEEALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTESFKAPELGVGNLGASEKSDVFLVVSSLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSDGTIDEESAKQILKDTLTGEMSPLPTDVRRITPKKLRELSDLLRTHLSSAATKQLDMGVVLSDLDTMLVALDKAEREGGVDKDQLKSFNSLILKTYSVIGAYIKGREGDTKSSSTEVSPYHRSNFMLSIVEPSLQRIQKHLDQTHSSDIGSLMRAHKHLETLLEVLVTLSQQGQPVTSETYSFLNRLAEAKVTLSQQLNTLQQQQESAKAQLSILINRSGSWADVARQSLLRFDSTRPVVKFGTEQYTAIHRQMMAAHAAITLQEVSEFTDDMRNFTADSIPLLIQLGRSSLMDEHLVEQREKLRELTTIAERLNRLEREWM
Protein: Uncharacterized protein (Q383J4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLNLESLNTGLTRVVSVKKYPVTRRQQLHLSRTTKGRVFRIGVLHSKEMTEAMLLKNRRGFVNSQVNTVAHAPSLYHWLFHRCGVPFEEAAELASSGGLTVNGITVDRSELEAQRDWAAFQQKDILIRVPAPLSERTAGLSSRYGNKETPSNRDNNGETNGSSSSKASLWVPALKRALHRQYFLIYLHPGVSITSDQTDPRSFVHRLTPTIGSTAGLGMNILRPIGFMNGMKGIGIATNDVSMVRYWNNEFLGNFGVYDVRFPRGVPPEVLWRLSEEINADLDNGIRKQLSRDVKVPCTCAVEPVPIFKQHRQTQRRDVVSDVYPQALHNERLVIRTPLLPYRVARKIRHASGLTTLVRSGPFVFPPSLPEVKARQLSPQELALMFTFERKLKTNRVILSLREFEADAHDDIAGERRGL
Protein: Probable methyltransferase PMT17 (EC 2.1.1.-) (Q9SZX8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MAKENSGHHHQTEARRKKLTLILGVSGLCILFYVLGAWQANTVPSSISKLGCETQSNPSSSSSSSSSSESAELDFKSHNQIELKETNQTIKYFEPCELSLSEYTPCEDRQRGRRFDRNMMKYRERHCPVKDELLYCLIPPPPNYKIPFKWPQSRDYAWYDNIPHKELSVEKAVQNWIQVEGDRFRFPGGGTMFPRGADAYIDDIARLIPLTDGGIRTAIDTGCGVASFGAYLLKRDIMAVSFAPRDTHEAQVQFALERGVPAIIGIMGSRRLPYPARAFDLAHCSRCLIPWFKNDGLYLMEVDRVLRPGGYWILSGPPINWKQYWRGWERTEEDLKKEQDSIEDVAKSLCWKKVTEKGDLSIWQKPLNHIECKKLKQNNKSPPICSSDNADSAWYKDLETCITPLPETNNPDDSAGGALEDWPDRAFAVPPRIIRGTIPEMNAEKFREDNEVWKERIAHYKKIVPELSHGRFRNIMDMNAFLGGFAASMLKYPSWVMNVVPVDAEKQTLGVIYERGLIGTYQDWCEGFSTYPRTYDMIHAGGLFSLYEHRCDLTLILLEMDRILRPEGTVVLRDNVETLNKVEKIVKGMKWKSQIVDHEKGPFNPEKILVAVKTYWTGQPSDKNNNNNNNNNN
Protein: Protein LDOC1 (Q7TPY9)
Organism: Mus musculus (Mouse)
Function: May have an important role in the development and/or progression of some cancers.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MVEELLSLLHALLDRHQALCMENHQLLKQLRLLVCERARLLRQVCPPSCPVPYPSRFSGESGRLPEFIMQTMSYMLANEEHFCNDAMKVAFLISLLSGEAEEWVMPYIESNSYVLGDYQAFVDEMKQYFGWGTDDEDDGDDDEEEEMEEDH
Protein: Excitatory amino acid transporter 4 (High-affinity neuronal glutamate transporter) (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6) (O35921)
Organism: Rattus norvegicus (Rat)
Function: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:26690923}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Excitatory amino acid transporter 3
- Histone acetyltransferase KAT5
- RAR-related orphan receptor A
- Rho guanine nucleotide exchange factor 11
Sequence:
MSSHGNSLFLRESGAGGGCLQGLQDSLQQRALRTRLRLQTMTREHVRRFLRRNAFILLTVSAVIIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSRVTGMASLDNKATGRMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGLHREGRIETVPTADAFMDLVRNMFPPNLVEACFKQFKTQYSTRVVTRTIVRTDNGSELGASISPPSSAENETSILENVTRALGTLQEVISFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGGVLPLIYFLVTHRNPFPFIGGILQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLGKPYKSLMAQAKGASRGRGGNESVM
Protein: Type II iodothyronine deiodinase (EC 1.21.99.4) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase) (Q9Z1Y9)
Organism: Mus musculus (Mouse)
Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92813}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q92813}.
Interaction partners:
- Type I iodothyronine deiodinase
- Lipid transferase CIDEA
- Mitochondrial brown fat uncoupling protein 1
- Histone-lysine N-methyltransferase PRDM16
- Monocarboxylate transporter 8
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Very long chain fatty acid elongase 3
- Cytochrome c oxidase subunit 8B, mitochondrial
- Thyroid hormone receptor alpha
Sequence:
MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPESGNNYASEKTADGAECHLLDFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRUILD
Protein: Insulin-like growth factor 2 (Insulin-like growth factor II) (Q9PTB0)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
RPVGRNNRRINRGIVEECCFRSCDLALLETYCAKSVKSERDLSATSLAGLPALNKESFQKPSHAKYSKYNVWQKKSSQRLQREVPGILRARRYRWQAEGLQAAEEARAMHRPLISLPSQRPPAPRASPEATGPQE
Protein: Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Q8MQ70)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase required in the somatic gonadal cells to regulate germline proliferation during larval development and in adulthood. Plays a role in the development/differentiation of gonadal distal tip cells. Required for normal lifespan in a pha-4 and mxl-2-dependent manner. Also contributes to survival following heat or oxidative stress. Prevents sumoylation and inactivation of heat shock transcription factor hsf-1 which enhances hsf-1-dependent transcriptional induction of chaperones in response to heat shock. Also required for hormetic extension of longevity in response to heat stress. Provides protection against polyglutamine aggregate formation and associated locomotory toxicity. Also contributes to longevity by promoting autophagy under nutrient stress conditions through induction of autophagosome formation and autophagy gene expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:12618396, ECO:0000269|PubMed:23904186, ECO:0000269|PubMed:29036198}. Note=Localizes to nuclear moving puncta. Puncta number and intensity decrease in the adult (PubMed:12618396). In some large cells, a nuclear speckle pattern can be detected (PubMed:23904186). {ECO:0000269|PubMed:12618396, ECO:0000269|PubMed:23904186}.
Interaction partners:
- Core-binding factor subunit beta homolog bro-1 homolog)
- Runt-related transcription factor rnt-1
- Sentrin-specific protease
Sequence:
MPKRKNSGQSTDLNSRSPKTIDEALRILAPPQALLVQSQLNLTAPANPFSIQKAPGTSSDNEQRAPKRRADEEAVNAVPKNLLTTSSTFARAVIPAAPAISSANNKMAPQSVTATAKTTTNRGKVSGEGEYQLIKNEVLCSPYGNQYEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNENSEEFNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAELFLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSESPNHTNVGGSYYRLKTVEEYEASSSTAKSKETRKYIFNVIDDISRVCYGFESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFVTMTHINGYNFANYVHEAHKRMEICRKPGPAMATPYRAANVATPITPVEKPPAPKLQQPMIAVLPQLNQIAATNIPPVPTQPDLTNLMHHYSQMAAATGSAATAAQFFYQPLPPAPLFQYAQLHHPFAARPPHFLSLATPSHMVPQFVPVPIMDPSMLQGQWPPGAAQQFAVLANDIMRVPAPQGINQMFASTPQTFSLPQFLSSSIPSATTAFNGNAPNIPFPEENSSWALGTAAQQQQQQAQRAQSMINGNVKVKPLAAQPKKNSPAPSVITLSSDEDSNGAGSSNSGSTTRTGAVNPVRNDTLPMGNTIKTEDILVPPTTFDGQLPNLQYFPGSHLFDPKTVAGLLPNPFLDTSHIPRAFN
Protein: adenylate cyclase (EC 4.6.1.1) (Q19523)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Guanine nucleotide-binding protein G
- cAMP-dependent protein kinase catalytic subunit
- Probable 3',5'-cyclic-AMP phosphodiesterase pde-4
- Probable 3',5'-cyclic phosphodiesterase pde-5
- Probable 3',5'-cyclic phosphodiesterase pde-2
- Probable 3',5'-cyclic phosphodiesterase pde-1
- Probable 3',5'-cyclic phosphodiesterase pde-6
- Probable 3',5'-cyclic phosphodiesterase pde-3
- Phosphodiesterase delta-like protein
- Bis
Sequence:
MDDDVGERTPALGGSCGPSVRAHSSSPRRVPLFERASARWWNPQFRSATLEAQYWKCSFSQLRDRFRSGLIYIAVVIAAWTLYLALFDRTFIQHWIVSLCLCAIIFAMFAFTACAAQYQRFYMPTSFLCTFLICLVTLLIFSAENQAAFMTPVASLATSFQVVLLIYTVIPLPLYLCILIGIIYSILFEILNKNKIGLEEAGYIKLVLHAGVHLLGVHLFILTQVRQRKTFLKVGQSMLARKDLELETQFKDHMIQSVMPKKVADELLKDASELRRPSASNDSNCRTSNATQVDQPLAKMVPEYRKFRPFTMNLMTNVSILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLEKISTLGDCYYCVAGCPEPCDDHACRTVEMGLDMIVAIRQFDIDRGQEVNMRVGIHTGKVMCGMVGTKRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIEEGPDYDGPLRMQVQGTERRVKPESMKTFFIKGRINDGVEEEVMQVQEVESLHSQKSSKKSTLKQKWAEKLKMNHTNSYPMRAAAREGGGSLRIKLAERNRSTQLLPKESNSICIMEDNRKSASLQALATNNFNGSNTDTNNTYSERGVAGSVSKKSVAGSESNSIKGSRSSGLQLSLQDGNSDLNSVGGLDTAISHHHNAASLTRFDTDNNFDQRLAMVIGQGEGGFDKGFWNHHDSLNKWTLRFNEKDVEEEYRAHFVDSSERYTASKKGHVERHKDLMEQGGEKDGITGSTVNKYRYSGVFIDIIVATLIFVISGAVAIMSVRPFPLSLIAYFPFAAAILILTIVLIGLPLLARKKSFQCANQWMPRHLIGLLLIFLPIGVAICIMPLCQSGDCANVILNYRLAFSYVTILAIFAHCNFSQLAAWPKTTAAVFIGLLHIAGVFYCEFNLKHLVEEQDTCNVTAIMIPPIRKGLNYTIALNSTSARTLSQDFGSPLFIWELLLDVILSIVLVAFLNYQFETAFRMSFFGDVQARRDTERMQIVRDQADWLLNNVIPAHAVESLKTDTKYSENHETVGVLFASITNWNDMYEENFEGGREFLRVLNEVIGDFDELLDRPDFTHIEKIKTIGPAYMAASGLNPERKKNMLHPKEHLYQMVDFALAVQHVLSVFNEDLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTREYLLDRYEFEFRDHIEVKGIDGGMDTYLLVGRKGDGIPPSIKDNQEDEF
Protein: Secreted protein involved in flagellar motility (O25998)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- C4-type zinc ribbon domain-containing protein
Sequence:
MFDKKLSSNDWHIQKVEMNHQVYDIETMLADSAFREHEEEQDSSLNTALPEDKTAIEAKEQEQKEKRKRWYELFKKKPKPKSSMGEFVFDQKENRIYGKGYCNRYFASYVWQGDRHIGIEDSGISRKVCKDEHLMAFELEFMENFKGNFTVTKGKDTLILDNQKMKIYLKTP
Protein: LD10456p (Tif-IA) (Q9V9M6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RNA polymerase I subunit F
- DNA-directed RNA polymerase I subunit RPA1
- DNA-directed RNA polymerase I subunit RPA2
- DNA-directed RNA polymerases I and III subunit RPAC1
- LD14127p
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerases I and III subunit RPAC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
Sequence:
MSFYTSKTDVTSILKTFSGVKRNQANAVAINKVRFSTPKEKGLAESVRVALEERNFHLVKEFTYFLREAELSDDEVVIIIKDAKRIVHNLTPEFVTVVEALLSLNWKKRSSEIIEAYTEFCIELMVTHNRYLPIGVSKLIVHWIPGDMDESDWVHGCPSEHVRNELKPIHKVLDRILTAVPMAFDIIIDAISAKFPYFKKPYHVTAGYLYNVLWLLEYKPIFEELVFQLVLQKLLLLDVNAPKDEIELEMNDEEEKVEADTLFEIDDVCAENVPKSEKSVSHPVGKTLDVCLFLLYKFFDGKCRLNENSSEEQRRTANRLFKMLLYLFDEVLLPSHNTHHVQFILFYATSLRSVYSEAFLDSLWTKVQNPNVSAVIRHAAVGYMASFLSRARFLPLSTVTFYLKELTRWAHTYIDDSDAYKQNCSLKANLVFYSVCQAVFYLIAFRAKDLTASSKDLLFLQSLQLSRLAMCHLNPLRYCLAPVATAFAGVTRTYQLAYCHTVLERNARRKLATVYGHEKCMPDETLESFFPFDPYVLKLSKKYIETNYMVYQSNDTDEYVYGSNKYGHSRKRGDSEMLEEDEFLIVDKRPKNFDLSKSQEFDKQFHFGSSP
Protein: Aminopeptidase N (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (Microsomal aminopeptidase) (B4DV63)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK