wanglab/gogpt-training-data huggingface dataset:
Protein: Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) (Q9Z2H5)
Organism: Mus musculus (Mouse)
Function: May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Glutamate receptor 1
- Ezrin
- Radixin
- Moesin
- Myosin-9
- Disks large homolog 1
- Plastin-1
- Unconventional myosin-VIIa
- Taperin
- Fascin-2
Sequence:
MTTETGPDSEVKKAQEETPQQPEAAAAVTTPVTPAGHSHPETNSNEKHLTQQDTRPAEQSLDMDDKDYSEADGLSERTTPSKAQKSPQKIAKKFKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPEGDKREDDAESGGRRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWDRERRLPSSPASPSPKGTPEKASERAGLREGSEEKVKPPRPRAPESDMGDEDQDQERDAVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGGAFEDFSRSLPELDRDKSDSETEGLVFAQDLKGPSSQEDESGGLEDSPDRGACSTPEMPQFESVKAETMTVSSLAIRKKIEPEAMLQSRVSAADSTQVDGGTPMVKDFMTTPPCITTETISTTMENSLKSGKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES
Protein: ADP-ribosylation factor GTPase-activating protein AGD1 (ARF GAP AGD1) (Protein ARF-GAP DOMAIN 1) (AtAGD1) (Q9FIT8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable GTPase-activating protein (By similarity). Regulator of membrane trafficking. Required for maintaining a straight growth of root hairs.
Subcellular location: Endosome {ECO:0000269|PubMed:18539780}.
Interaction partners:
- Uncharacterized protein
- Ras-related protein RABA4b
- Phosphatidylinositol 4-phosphate 5-kinase 3
- Phosphatidylinositol/phosphatidylcholine transfer protein SFH1
- ADP-ribosylation factor GTPase-activating protein
- Phosphatidylinositol/phosphatidylcholine transfer protein SFH2
- Phosphoinositide phosphatase SAC7
- Rac-like GTP-binding protein ARAC4
Sequence:
MHFAKLDDSPMFRQQMQSMEESAELLRLRCLRFYKGCRKYTEGLGEGYDADIGFVNALESFGGGHNDPVCVAFGGPVMTKFTIALREIGTYKEVLRSQVEHMLSDRLLQFVNGDVHEVKEARKRFDKATITYDQAREKYLSLRKSTRLDVAATIEEDLHSARTTFEQARFHLVSALSNAESKKRFEFLEAVSGTMDAHLRFFKQGYELLHQMEPFINQVLAYAHQSRECANYEMASLNERMQEYQRQVDRETRNSCVSPTGDGMRHNSRNSQKVIEAVMQSAAKGKVQTIRQGYLSKRSSNLRGDWKRRFFILDSRGMLYYYRKPWNWSSGNGSRSVVHRNMASENSPGLLSRWLSSHYHGGVHDEKPVARHTVNLLTSTIKVDADQTDLRFCFRIISPTKVYTLQAENAQDQMDWIEKITGVIASLLSFQTPERAIMRLSTVDGGDTFSASDSGSLADPYDIEQAESGESTVEHPMTGGNRSRFSGCLQQHDMVKTEKPIDVLTRVLGNERCADCGAPEPDWASLNLGVLICIECSGIHRNLGVHISKVRSLTLDVKVWEPSVLTLFQSLGNVYVNSVWEELLNSESRTSSASRSSGTPKSDRPRKLLVRKPGFNDPISVKELFIHAKYSERIFVRKAIDSQHFQAVFQEIWENVRANDKKSVYRHIVCSEADVNALRGQASYTVSLPLSKMMQMEETLEAKFKSIEEEFQENPAGYSNSRGDGESMVREETSNDCSLLHLACLSADIGMVELLLQYGAKINATDSKGRTPLHHCIISRRYAIARLLLMRGGDPNAVDKDSNIPVKYASQTDLNDSELIALLTDSKR
Protein: ACP24A4 (Accessory gland protein 24A4, isoform B) (Accessory gland protein 24A4, isoform C) (GEO10734p1) (IP06005p) (IP06105p) (Q4V621)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform B
- Major facilitator superfamily
- FI08238p
- FI08446p
- IP12902p
- Phenoloxidase-activating factor 2
- Seminal fluid protein 24Bb
- AT04270p
- Glycerol-3-phosphate dehydrogenase
- Reticulon-like protein
Sequence:
MKLLILLFVFIALASNSLALKNEICGLPAAANGNCLALFSRWSYDAQYNVCFNFIYGGCQGNENSFESQEECINKCVE
Protein: Gamma tubulin ring protein (Q9GP62)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MATVAECNHSVLDLVTKMATMLVADETKPKKQTAALVAKKRSKIYESLLHSETMSSQDKLEMLHQVTSEVAKNPDRMDMLLRFQNLLEGQDREESEITQDQDEENQSEVVIKRIKAGPLQLIETIEIVEEALHPKAFPDINQMNRALKPLQLQPYSDILTTSNLNINFPPEKLIPKIIPSTVIRMGLSESITRMRNEMEKPMHPPPRLPVLAKKVVAPLEDERPFVAQPGPEKHFVSDKLLTNELKILRNKNLVLNYLNEATLIDHLKKAACGIESLTFPISSADKLELRVRPNTTLPTMLPEVLADFANHFIRAGCAFLRLSSRTKWNNIAEMRLERPLNRAMRETIMDYLSTTRQFLLSLQADSLFQLLNNTSTAIQLLCQLDRMFENEPRLNLNTGITGSFLLSSIWLAIDTCGNKDFLHLLIYFLRCISRNYFIQLQRWIYHGELDESVNEIFISRCLNTSPSFTNQCSKEFFDKSYQVDNEAIPEFLVGCEEEILQCGKYNLVLRAYNAQHPVFDVQYPDIVVCLTEQQLKNMRRNLADKYAIIYKRFGWCSMQSIFEDRMATKRVFANLMVKRTQAHLDAWAQKQRELQIKANAQKKLQNDQLNAEQERIQQNHLEKRRQDIVNELAFQRECERMEDKLLEREKQELQKKVVQLAAVLSSSPDRSTVSDLSFASCIEEPDCLAESSSDKDDANTENSEDEATKQLDKTLNVPLEQPEAEYQADVDVDQPRGKECSLPNVFQYQRSHSDVINSNEHPTTQAEFNRNRQHGLSSDQFQQCHATVHLQESDLLKTAASTSSGLHAEIPQDINANLNCPDTKELTELQRNRKRNEHHDGFFSFNSTEDEHTHRLRSLLNSNTERGRNRLRVMETEFGLGYKNTDIETKATPCLPLEIDKLHVEIPLAVLTPMSTTSDVDFGDPSPRELPEIADTANNNNVSGSIESLSPELPKPVLAIAKPTSLLPKLDFGMKDERETEQDRDKVSTLPEACNPFMARRCLQLSVMAPLNAYYGLLRNEVLRIFQEQRIYEHFRKLRNYFFLVDGQFGATLTNEILGRIRAGVGPRSLSQKGILDTILTNALAACSADETTVSENLTLNCTTIPDTLNFLSVEATSMLKLNCKIDWPLNMVISSETISKYGQIFGYLLKLRHVSFVLDGTYEYLQQMGKLLGPELRTCTHFRHMQMMRHKMSHFMTSFQTHLVAKALLSTWKSFKEELCTADSIEALYKQHVAYLKRVAFLALLNRRSAKVKETIDNILVIILRFCKVIQSQSFIVDQDNYFVHPRFKRLQQEEAEFEKFLQYLIYLGNKAAASGYQEEIGDLICIINFNHYYKVSGNHTGSSMEDKKC
Protein: Phytase A (EC 3.1.3.8) (Histidine acid phosphatase phyA) (Myo-inositol hexakisphosphate phosphohydrolase A) (Myo-inositol-hexaphosphate 3-phosphohydrolase A) (A2QIG7)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MGVSAVLLPLYLLSGVTSGLAVPASRNQSTCDTVDQGYQCFSETSHLWGQYAPFFSLANKSAISPDVPAGCHVTFAQVLSRHGARYPTDSKGKKYSALIEEIQQNATTFEGKYAFLKTYNYSLGADDLTPFGEQELVNSGVKFYQRYESLTRNIVPFIRSSGSSRVIASGNKFIEGFQSTKLKDPRAQPGQSSPKIDVVISEASTSNNTLDPGTCTVFEDSELADDIEANFTATFVPSIRQRLENDLSGVSLTDTEVTYLMDMCSFDTISTSTVDTKLSPFCDLFTHEEWINYDYLQSLNKYYGHGAGNPLGPTQGVGYANELIARLTHSPVHDDTSSNHTLDSNPATFPLNSTLYADFSHDNGIISILFALGLYNGTKPLSSTTAENITQTDGFSSAWTVPFASRMYVEMMQCQSEQEPLVRVLVNDRVVPLHGCPVDALGRCTRDSFVKGLSFARSGGDWGECFA
Protein: Calsyntenin-2 (B0S5G3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9ER65}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000250|UniProtKB:Q9ER65}.
Interaction partners:
- Kinesin light chain
- Scm polycomb group protein-like 2
- Adherens junctions-associated protein 1.
Sequence:
MKMRAITAMLLLVLSGQCGILAGKVNKHKPWIETSYHGVITENMDTVMLDPPLVALDKDAPVPYAGEICAFKIHGQEAPFEAEVLNRTSGEGVLRARGPIDCEQQKEYTFIIQAYDCGASPNGADWKKSHKAVVHIQVDDVNEFSPVFREPLYRATVTEGKIYDSILQVEAWDQDCSPQYSQICNYEIVTQDTPFAIDRNGNIRNTERLSFDKQQHYKIMVTAYDCGQKRAMESVPVHIDVKPVCKPGWQGWNKRVDYEPGTGSKQLFPKMHLETCDGPLSSVRAMVELQTSHIGKGCDRETYSEKSLQKLCGAASGSTDLLPAPSTSTNWTASLLTDSGRDSDLIFRFDGRQAANIPDWVVPQNLTDQFTIATWMKHGPSPGLRAEKETLLCNSDKTEMNRHHYSLYVHNCRLVFLLRRDFIQLDSFRPAEFHWRLEQICDKEWHYYVINVEFPSVTLFVDGVTYEPYLVTDDWPIHPSEIDVQLTVGACWQGGEVTTPRFTQYFRGSLSGLTIRPGKIATQKVISCLQACKEGLDISSLESLGKGIKFHFNPAQSVLVMEADDLESINTAMTKVSYINSRQFPTPGLRKLHITTTVQCFGEDTCISIPEIKAMVMVLPPSEPRITIAGVERLVWPSAQLRAPVGVALFKDIHIISTVTKTDATLSIARRPGVLELMHNLDYCDVLVIGEELDPERESLEIHHSSLLGKHLDATNSTSGISIYGVDSMAHYEQAIRQVRYRNWKPGSLSERRFRLSCSELNGRYTSNEFNLEIGVVHSSEAVEHVNHMAVQSQFMRPVHHPLVVHTVNSDHISGTPPAATVVIVMCIAALVVIVVLGIYRIHTTHQDSSKEDEEERKDPEMDWDNSNLNSIEGTQIAEEVREEEPEEDEDEDEEDDDLAGDLSSAESEDSDEDEETNIQKGKVKGKLEWDPSTLPY
Protein: Rhodopsin kinase grk7-b (EC 2.7.11.14) (G protein-coupled receptor kinase 7-2) (G protein-coupled receptor kinase 7B) (Q1XHL7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q8WMV0}; Lipid-anchor {ECO:0000250|UniProtKB:Q8WMV0}.
Interaction partners:
- Recoverin
- Recoverin b
- Recoverin a
- Recoverin 3
- Rhodopsin
- Green-sensitive opsin-2
- Green-sensitive opsin-4
- Rhodopsin.
- Green-sensitive opsin-3
- Rhodopsin
Sequence:
MSDMGGLKNLVANTDYLKAQSLDEKEIKKRRCSLGLPHLGNCTDVRVSVSKGFEDICEQQPIGRACFRQFLSVSSPEYLAAAELLDELNCWNLAEAEAKEEARLNIINKFCKADSKSFLAFLTEDEAEKCKAVSEKDFEEVMMGQVKEATQKFLRGQPFEEYQTSLFFDRFVQWKKFEKQPITDKYFYEFRTLGKGGFGEVCGVQVKTTGQMYACKKLDKKRLKKKSGEKMALLEKKILEMVNSLFIVNLAYAFDTKTHLCLVMTLMSGGDLKYHIFHVGEVGIEMERIIHYTAQITSGILHLHSMDIVYRDMKPENVLLDCQGQCRLSDLGLAVELPNGKTTTQKAGTKGYMAPEILKQEPYRTSVDWWALGCSIYEMVAGRVPFRDHKEKVAKEELLRRTLEDEVKFEHRNFDAPSKDIISLFLKRNIEDRLGSNDDPRKHEFFKSINFPRLEAGLIPPPWEPKANVVYAKDTGDIREFSDVKGVKFDANDEKFFKEFSTGVVPIAWQQEMIDSGLFDELSDPNRKESAAGLEDEEQQKSKSCTLL
Protein: ADP-ribose pyrophosphatase, mitochondrial precursor (EC 3.6.1.13) (Nudix (nucleoside diphosphate-linked moiety X)-type motif 9) (F1QL34)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- ADP-sugar pyrophosphatase
- Ribose-phosphate pyrophosphokinase 1
- Ribose-phosphate pyrophosphokinase 1
- Transient receptor potential cation channel, subfamily M, member 6.
- Phosphoglucomutase 1
- Phosphoglucomutase-2
- Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
- Transient receptor potential cation channel, subfamily M, member 4a.
- 8-oxo-dGDP phosphatase NUDT18
- Transient receptor potential cation channel, subfamily M, member 5.
Sequence:
MKSVSRKWVASVHVALSLIGLPFSAGTSGSCRRNGISFIPSVFASSSSSSSTLRMASPAHIKARCAVYPGSDTHRFPVPDDKVDWETDWPQYSPVNYTAPAVLKKPVWADLEIGAFCPQFNLLDGSVDRRSHEGQYRIQNGKPLNPHGRTGLEGRGLLGRWGPNHAADPIVTRWKIDSSGQRFLHADSKLPVLQFVSIKRLDCGEWAIPGGMVDPGERISQTLQREFSEEALNSLKASDSEREKIQKRISELFSSAGLQVYIGYVDDPRNTDNAWMETVAVNFHDESGDSVSELPLQAGDDAGQVSWTDIDSSLALYANHSQFLKTVAEERKAHW
Protein: bZIP transcription factor 1 (bZIP protein 1) (Pibzp1) (Q5BUB4)
Organism: Phytophthora infestans (Potato late blight agent) (Botrytis infestans)
Function: Required for normal zoospore movement, formation of appressoria by germinated zoospore cysts and plant infection.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MNLSRFAPSPSSDSLISTLRPRAAVRRLHSNITGPMTPFKTAVNAYVASEGTDNSYVVRPRLYNDKRAQSDGSNALLSSIGPSGTTKRPRDEMDCFTDTHKHKRGDGNKSRRREQCRANQARYRDKQRNAQQQLERSVEQLQSELSTLKHRNLDLASRQRTNQSPWNTVAEVFRLLGVCFRSPWRVTCVQEMRNHSEMRQILAILERSFTHDVAMGDLRGIDALMEQLLQFSQY
Protein: (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase (EC 1.13.11.80) (Q8KLK7)
Organism: Streptomyces toyocaensis
Function: Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. Catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate. DpgC performed a net four-electron oxidation of the benzylic carbon of DPA-CoA and the hydrolysis of the thioester bond to generate free CoA. DpgC has the ability to process a diverse range of substituted phenylacetyl-CoA substrates.
Interaction partners:
- DpgB
- Circadian input-output histidine kinase CikA
- 3,5-dihydroxyphenylacetyl-CoA synthase
- enoyl-CoA hydratase
- Mixed polyketide synthase/non-ribosomal peptide synthetase
- GntR family transcriptional regulator
- Carrier domain-containing protein
- Acetyl-CoA acetyltransferase
- Acetyl-CoA acetyltransferase
- Acetyl-CoA acetyltransferase
Sequence:
MTTVLPPLEDTDGLWAALTEAAASVEKLLATLPEHGARSSAERAEIAAAHDAARALRVRFLDTHADAVYDRLTDHRRVHLRLAELVEAAATAFPGLVPTQQQLAVERSLPQAAKEGHEIDQGIFLRAVLRSPLAGPHLLDAMLRPTPRALELLPEFVRTGEVEMEAVHLERRDGVARLTMCRDDRLNAEDGQQVDDMETAVDLALLDPGVRVGLLRGGVMSHPRYRGKRVFSAGINLKYLSQGGISLVDFLMRRELGYIHKLVRGVLTNDDRPGWWHSPRIEKPWVAAVDGFAIGGGAQLLLVFDRVLASSDAYFSLPAAKEGIIPGAANLRLGRFAGPRVSRQVILEGRRIWAKEPEARLLVDEVVEPDELDAAIERSLTRLDGDAVLANRRMLNLADESPDGFRAYMAEFALMQALRLYGHDVIDKVGRFGGRPPA
Protein: Large ribosomal subunit protein uL3m (39S ribosomal protein L3, mitochondrial) (L3mt) (MRP-L3) (Q99N95)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P09001}.
Interaction partners:
- Large ribosomal subunit protein bL19m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein bL9m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS5m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein bL20m
Sequence:
MPGWRLLAQAGARVLGCGARGLGADPGLERRKNILFFVRNLHSKSSTWWDEHLSEENLSFVKQLVSDENKTQLTSKLNPLKDEPWPLHPWEPGSFRVGLIALKLGMMPLWTKDGQKHAVTLLQVQDCHVLKYTPKEDHNGKIAALTVGGKTVSRFYKPDSRLEFYRDLGLPPKQIHKIFHVTDNAVIKPGTPLYAAHFRPGQYVDVTAKTIGKGFQGVMKRWGFKGQPASHGQTKTHRRPGAISTGDIARVWPGTKMPGRMGNQNRTVYGLKVWRVNTKHNIIYVNGSVPGHKNCLVKIKDSTLPAYKDSCKNLPFPTYFPDGDEEELPEDLFDESVWQPSEPSITFA
Protein: deoxyribose-phosphate aldolase (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Q582I3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribokinase
- Transketolase
- Transaldolase
- Triosephosphate isomerase
- Fructose-bisphosphate aldolase
- Glucose-6-phosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase, putative
- Glyceraldehyde-3-phosphate dehydrogenase
Sequence:
MTDLHMRERQGFTGKLNDALLERVHFVSRRLNLPQIESKFPHLSVSDGSWRKSPPGDDVNLATFIDHTLLKPEATQALIMKLCKEARDHRFHAVCVNGSRVRCCVKALKGSGVRVAACCGFPLGAGSTEAKVAEAVAAVRDGAADIDMVINVGAVKERNYCLVYSDIKAVVDACGHNVTTKVIFETCLLTPEEIIDCCILSVAAGASFVKTSTGFNIGGATPEAVDMMLATVGNEAKVKVSGGVRDRETALQYVKVGVSRIGTSSGIAIITHTDRSRSKY
Protein: Vesicular glutamate transporter 2.1 (Protein blumenkohl) (Solute carrier family 17 member 6-B) (Vesicular glutamate transporter 2-A) (Q5W8I8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular L-glutamate uptake. The vesicular H(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine L-glutamatergic system of other tissues such as pineal gland and pancreas (By similarity). Required for glutamate release by retinotectal synapses and visual acuity.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Synapse, synaptosome {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:Q8BLE7}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glutamate decarboxylase 1b.
- Transporter
- Glutamate decarboxylase 2
- ELAV-like protein
- Vesicular inhibitory amino acid transporter
- Homeobox protein engrailed-like
Sequence:
METPREPAGFSKEGLKQLAGKTLGHVYRVIEKRQKPGENIELTEDGRPAQINERKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTIHLNGKIIIKEKAKFNWDPETVGLIHGSFFWGYIVTQIPGGYISSRLAANRVFGAAILLTSTLNMFIPSAARGHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGCFGIFWYMFWILVSYESPAEHPTITAEERCYIEESIGESAKLLGPADKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSALPHLVMTIIVPIGGQLADHLRSKNILSTTTVRKIMNCGGFGMEATLLLIVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGIFASGEKQPWADPELTSDEKCGFIDEDELAEETGDITQSYGALGAPAKSYGATTQLNGGWAEGWDKREEYVQDGVEEGGYGYRQGGNYS
Protein: Fibroblast growth factor (FGF) (Q2LJ24)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Fibroblast growth factor receptor 1-A
- Fibroblast growth factor receptor.
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor 3
- Fibroblast growth factor receptor 2
- receptor protein-tyrosine kinase
- Platelet-derived growth factor receptor, beta polypeptide
- receptor protein-tyrosine kinase
- Platelet-derived growth factor receptor alpha
- Vascular endothelial growth factor receptor kdr-like
Sequence:
MAAMGEIGTFLQSLEGFGQVGSQFFLPPLGENLGLLNDHLFPAERLSRSTSADLTHLKGILRRRQLYCRTGFHLEILPDGSVQGTRKDHSRFGILEFISLAVGLISIRGVDSGLYLGMNDKGELYGSEKLTAECVFREQFEENWYNTYSSNLYKHGERGARYFVALNKDGTPRDGTKSRRHQKFTHFLPRPVDPEKVPELYKEVLGHS
Protein: Insulin-like growth factor 2 receptor (A0A8I6AI55)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004608}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
Interaction partners:
Sequence:
MESYTWEAVDSKNNAVYKINPCGHVDNPRCGPTSAVCMCDLKSENCRSVGDSLLRSSAKSLLEFNTTTGCQPSEHRIQTSITFLCGKTLGTPEFVTATDCVHYFEWRTTAACKKDIFKADKEVPCYVFDDKLQKHDLNPLIKLNGGYLVDDSDADASLFINVCRDIDSLRDPSTQLRVCPAGTAACLLKGNQAFDVGRPKEGLKLLSKDRLVLTYVKEEGEKPDFCNGHSPAVTVTFVCPSERREGTIPKLTAKSNCRYEVEWITEYACHRDYLESETCSLSSEQHDIAIDLSPLAQHEEGSPYVADGGEYRFFMNVCGDTKVSLCNKEAAVCQEKKVDSTQVKIAGRHQNQTLRYSDGDLTLIYSGGDECSSGFQRMSVINFECNKTAGQDGRGEPVFTGEVDCTYFFTWDTKYACVKEKEDLLCGAIDGKKRYDLSVLARHSESEQNWEAVDGSQAESEKRNFFINVCHRVLQAGKAKNCPEGAAVCAVDKSGSKNLGKFVSSPTKEKGHIQLSYSDGDDCGNDKKITTNITFVCKPGDLESAPVLRAAGPDGCSYEFEWHTAAACVLSQTEGENCTVLDAQAGFSFDLSLLTKKNGAYKVETDKYDFYINVCGPVSVNLCQSNSGACQVAKSGKSWNLGLSNTKLTYYDGMIQLSYRNGTLYNNEKHTPRSTLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECMVTDPSMMEQYDLSSLVKFEGGRGGNWYAMENSREHFTRRKYYLNVCRPLNPVPGCDRYASACQMKYENNEGSLAETVAISNLGVAKTGPVVEESGSLLLEYVNGSACTTSDGRLTTYSTRIHLVCGRGTMNSHPIFTFNWECVVSFLWNTEAACPIQTITDSDQACSIRDPNSGFVFNLSPLNYSQGHMVLGIGKTFVFNICGTMPACGTVAGKPALGCEAETKIKDIKDLKPERPVGMEKSLQLSAEGFLTLTYKGSSPSDRGTAFIIRFICNGDIYPGTPKFLHQDIDSARGIRNTFFEFETALACIPSVVDCQVTDPAGNEYDLSALSMVRKPWTAVDTSVHGKKRRFYLSVCTPLPYIPGCDGIAMGSCMVSEDKSQNLGVVQISPQATGNGSLSILYVNGDRCGNQRYSTRIVFECAQTSGSPMFQLLNNCEYVFVWRTVEACPVVREEGDNCQVKDPRHGNLYDLKPLALNDTIISAGEYTYYFRVCGKLSLDVCSAHDGSKAVSSCQEKKGPQGFQKVAGLLNQKLTFENGLLKMNYSGGDTCHKVYQRSTTIYFYCDRTTQKPVFLKETLDCSYLFEWRTQYACPPFNVTECSIQDEAGNSIDLSSLSRYSDNWEAVTRTGATEHYLINVCKSLSPQAGTDPCPPEAAVCLLDGSKPVNLGRVRDGPQWTAGVTVLKYVDGDLCPDKIRKRSTIIRFTCSDSQVNSRPLFISAVQDCEYTFSWPTPAACPVKSNIHDDCQVTNPSTGHLFDLSSLSGKAGITASYSEKGMVFMSICEENVNCSPGVGACFGQTRISVGQASKRLSYKDQVLQLVYENGSPCPSKSGLRYKSVISFVCRPEAGPTNRPMLISLDKQSCTLFFSWHTPLACEQATECTVRNGSSIIDLSPLIHRTGGYEAYDESEDDTSDTTPDFYINICQPLNPMHGVPCPAGASVCKVPVDGPPIDIGRVTGPPIFNPVANEVYLNFESSTPCLADKYMNYTSLIAFHCRRGISMGTPKLIRNNDCDFVFEWETPIVCPDEVKTQGCAVTDEQLLYSFNLTSLSTSTFKVTRDAHTYSIGVCTTAADLDQEGCKDGGVCLLSGSKGASFGRLASMQLDYRHQDEAVILSYVNGDPCPPETEDGEPCVFPFIYKGETYDECVLEGRAKLWCSKTANYDRDHEWGFCRPSNSHRMSAIIFTCDENEDIGRPEVFSEDRGCEVTFEWKTKVVCPPKKMECKFVQKHKTYDLRLLSSLTGSWDFVHEGNSYFINLCQRVYKGPLDCSERASICKKSATGQVQVLGLVHTQKLEVIDETVLVTYSKGHSCGGNKTASSVIELTCAKTVGRPAFKRFDIDSCTYYFYWYSRAACAVRPQEVNMVNGTLTNPVTGKSFSLGEIYFKLFSASGDMRSNGDNYLYEIQLSSISSSSNPACSGANICQVKPNDQHFSRKVGTSDMTKYYVQDGDLDVVFTSSSTCGKDKTKSVSSTIFFHCDPLLKDGVPEFSHETADCQYLFSWYTSAVCPLGVDFDDENAVPEYKGLSERSQAVGAVLSLLLVALTGCLLALLLHKKERRETVINKLTNCCRRSSGVSYKYSKVSKEEETDENETEWLMEEIQVPAARLGKDGQENGHITTKTVKAEALTSLHGDDQDSEDEVLTIPEVKVHTGRGAEVESSQPLRNPQRKVLKEREGERMGLVRGEKARRGKFRPGQRKPTTPAKLVSFHDDSDEDLLHI
Protein: UDP-glucuronosyltransferase 2A3 (UDPGT 2A3) (EC 2.4.1.17) (Q6UWM9)
Organism: Homo sapiens (Human)
Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Cytochrome P450 3A4)
- Cytochrome P450 2D6
- Cytochrome P450 1A1
- Cytochrome P450 2A6
- Cytochrome P450 2E1
- Cytochrome P450 3A5
- Beta-glucuronidase
- UDP-glucose 6-dehydrogenase
- Aldehyde oxidase
- Cytochrome P450 2A13
Sequence:
MRSDKSALVFLLLQLFCVGCGFCGKVLVWPCDMSHWLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKPSALKFEVVHMPQDRTEENEIFVDLALNVLPGLSTWQSVIKLNDFFVEIRGTLKMMCESFIYNQTLMKKLQETNYDVMLIDPVIPCGDLMAELLAVPFVLTLRISVGGNMERSCGKLPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYDYHFWEEFYSKALGRPTTLCETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALPKEMENFVQSSGEDGIVVFSLGSLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFLLACVATAIFLFTKCFLFSCQKFNKTRKIEKRE
Protein: Putative uncharacterized protein SLC66A1LP (PQ-loop repeat-containing protein 2-like) (Solute carrier family 66 member 1-like) (A1A4F0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKVVGNYRVNTANSSTDTSGEHLTCLRSQLFVAYRNGRVDEAVSLGFLDCWIGGDLTNFKGCYLTNQLPIQIFTAIFDMNTDVIILSQFMYYRLKNQKKKMIFQPQLFKDSITREKVRLSLWGVLCPVYIPYSFR
Protein: Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) (Q3T1J1)
Organism: Rattus norvegicus (Rat)
Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P63241}. Nucleus {ECO:0000250|UniProtKB:P63241}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P63241}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63241}; Cytoplasmic side {ECO:0000250|UniProtKB:P63241}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. Nuclear export of hypusinated protein is mediated by XPO4. {ECO:0000250|UniProtKB:P63241}.
Interaction partners:
- Exportin-4
- Deoxyhypusine synthase
- Ubiquitin-like protein FUBI
- GTP-binding nuclear protein Ran
- Deoxyhypusine hydroxylase
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS2
- Elongation factor 2
- Mitochondrial ribosomal protein S9
Sequence:
MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK