wanglab/gogpt-training-data huggingface dataset:
Protein: Homeobox even-skipped homolog protein 1 (EVX-1) (P49640)
Organism: Homo sapiens (Human)
Function: May play a role in the specification of neuronal cell types.
Subcellular location: Nucleus.
Interaction partners:
- Insulin gene enhancer protein ISL-1
- LIM/homeobox protein Lhx1
Sequence:
MESRKDMVVFLDGGQLGTLVGKRVSNLSEAVGSPLPEPPEKMVPRGCLSPRAVPPATRERGGGGPEEEPVDGLAGSAAGPGAEPQVAGAAMLGPGPPAPSVDSLSGQGQPSSSDTESDFYEEIEVSCTPDCATGNAEYQHSKGSGSEALVGSPNGGSETPKSNGGSGGGGSQGTLACSASDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAAAGGLPYPFPSHLPLPYYSPVGLGAASAASAAASPFSGSLRPLDTFRVLSQPYPRPELLCAFRHPPLYPGPAHGLGASAGGPCSCLACHSGPANGLAPRAAAASDFTCASTSRSDSFLTFAPSVLSKASSVALDQREEVPLTR
Protein: At1g55265 (Q8LEJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASSLLALFSCLFLSLLSLSSSLNLRRPIFSQSNDLDLFSSLNLDRPSLAADDIHDLLPRYGFPKGLLPNNVKSYTISDDGDFTVDLISSCYVKFSDQLVFYGKNIAGKLSYGSVKDVRGIQAKEAFLWLPITAMESDPSSATVVFSVGFVSKTLPASMFENVPSCSRNLNLQDS
Protein: Protein Largen (Mesenchymal stem cell protein DSC54) (Proline-rich protein 16) (Q569H4)
Organism: Homo sapiens (Human)
Function: Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration.
Interaction partners:
Sequence:
MSAKSKGNPSSSCPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSLEKIKVQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVKCEDPKRVVPTANPVKTNGTLLRNGGLPGGPNKIPNGDICCIPNSNLDKAPVQLLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYNIKNREVHLHSEPVHPPGKIPHQGPPLPPTPHLPPFPLENGGMGISHSNSFPPIRPATVPPPTAPKPQKTILRKSTTTTV
Protein: Peroxisomal targeting signal 1 receptor (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) (A0A0S2Z4H1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Peroxisome matrix {ECO:0000256|ARBA:ARBA00004253}.
Interaction partners:
Sequence:
MAMRELVEAECGGANPLMKLAGHFTQDKALRQEGLRPGPWPPGAPASEAASKPLGVASEDELVAEFLQDQNAPLVSRAPQTFKMDDLLAEMQQIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTATDRWYDEYHPEEDLQHTASDFVAKVDDPKLANSEFLKFVRQIGEGQVSLESGAGSGRAQAEQWAAEFIQQQGTSDAWVDQFTRPVNTSALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSATYDKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSTLLTMFGLPQ
Protein: S-adenosyl-L-methionine-dependent methyltransferases superfamily protein (F4I0B5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Transmembrane protein
- Transmembrane protein
- Transmembrane protein
- GAG1At protein
- At1g32920/F9L11_25
- AT3g62190/T17J13_150
- Mitochondrial Rho GTPase 3
- At1g10020
- Transducin/WD40 repeat-like superfamily protein
- RNA binding
Sequence:
MAALSDKLADAYQNARPRYPIDWFTKLAARTGQHKSAWDVGTGNGQAAIGVSFFHLVPKLAEYFEKVTATDINEAQLKRAVKHERISYHHTPTTMSEDQMVALVGGDNSVDLIVAAQAVHYFDLAPFYNVAKRVLRKEGGLIAVFVYNDIIISPEVDSIMKRLVDSTFPFRTPVMNLAFDGYKTLPFPFESIGMGSEGKPIMLDIPHKLSLKGFIGFLRSWQPAMKAKERGVELVTEDLISKFEDAWGDDDDVKDIFYKAHMIVGKLSASDIERHRKRFDTNCVVTTLKDHNNSAVIASVTAAAFAGVAAYCAYSARKNS
Protein: Putative uncharacterized protein YHR045W (P38775)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MNWSFLLQLVITILLIVLGANWLLSSFLLDFKRDLTGVALSQQSSISSVRKENETAYYRSILVPTGFPLTTGLGLSLKYKIRNGNFGDVWNAIMEVSKGKNIIKFTGREKSYSLSELNGMAKRIFPKLSNKNFKNIGIANSIATVEGFTLSLASMMTSIRTGSIPHFLPAVPRQRLEDVDVLIIDSWKSFKMLNGSEDWYKLIVVCDDPIESLQFDANCDVITWKELIDGFTKDTEYQYTPPDDNSDDKKLFAYVTSPWNGTNSFNQICLVSNIAEFIKGFPLGNELNSNEYLTISTKLANSSASLQIWGKLFAVLLHGGSASFINPTTIDCESLQETTLLFTETKDVVKLIDSNSRSGLLNKIYLSWATNLLSEGIFTKIARIEPHSLEKLRCVYLADNVKDAEVISTFPEKIPQLKKTNRRITPSTEQLNKIRAQLGSRVVLELYCPYAIMGPVAHTNFYDYRVFGKSVDDNVVCYGTLSTTLEGKMVETETNPHLNIEKKQGMLCIRGFSIGKPVESDRLEKALHLAERFGGGEGWMPLVGVFGLFGQDGCLYIYNQ
Protein: Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF) (P46099)
Organism: Mus musculus (Mouse)
Function: Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Subcellular location: Nucleus. Note=Colocalizes with SUMO1 in nuclear speckles.
Interaction partners:
- Erythroid transcription factor
- T-cell acute lymphocytic leukemia protein 1 homolog
- Zinc finger protein ZFPM1
- LIM domain-binding protein 1
- Erythropoietin receptor
- Glycophorin-A
- Rhombotin-2
- Histone acetyltransferase KAT2B
- Transcription factor PU.1
- Transcription factor SOX-6
Sequence:
MASAETVLPSISTLTTLGQFLDTQEDFLKWWRSEETQDLGPGPPNPTGPSLHVSLKSEDPSGEDDERDVTCAWDPDLFLTNFPGSESPGTSRTCALAPSVGPVAQFEPPESLGAYAGGPGLVTGPLGSEEHTSWAHPTPRPPAPEPFVAPALAPGLAPKAQPSYSDSRAGSVGGFFPRAGLAVPAAPGAPYGLLSGYPALYPAPQYQGHFQLFRGLAAPSAGGTAPPSFLNCLGPGTVATELGATAIAGDAGLSPGTAPPKRSRRTLAPKRQAAHTCGHEGCGKSYSKSSHLKAHLRTHTGEKPYACSWDGCDWRFARSDELTRHYRKHTGHRPFCCGLCPRAFSRSDHLALHMKRHL
Protein: Terpenoid synthase 30 (AtTPS30) (EC 4.2.3.-) (Q9LH31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in terpene biosynthesis in roots. Possesses sesquiterpene (C15) synthase activity and diterpene (C20) synthase activity in vitro.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Probable alpha,alpha-trehalose-phosphate synthase 7
- Probable alpha,alpha-trehalose-phosphate synthase 8
- Alpha,alpha-trehalose-phosphate synthase 6
- Probable alpha,alpha-trehalose-phosphate synthase 11
- Probable alpha,alpha-trehalose-phosphate synthase 9
- Putative inactive
- Cytochrome P450, family 78, subfamily A, polypeptide 8
Sequence:
MAVARTVFGLGTLSYLHQAPLFLKTSQSLFPRPSLSLKPMKHDFVCVKATTKSSTSDDLESGRPSILFSPSIWGDYFLSVSVDDSEFDDIAREIESVMKPYVRDRLISSHNSNKDKIRLIHLLISLGISYYFESEIEMILNKAFEELDMIIAEEDDLETISIMFEVFRLYQHKMSCDSFVRFKGEDGRLKESLVGDVRGMLQLYQAAHLGTPSDQYIMEEAKSFTRNHLESLVESTTIPPHFSSHIRDALYIDRYHNMEILVARKYISFYEQEEGHDLTLLKFGKLSFNYCRLHYIQELKTLTKWWKDQDIPSNLPCVRDRIVETYFPTLGLYFEPRFSLGRIIIAKMTIIVVALNDVCDSYATYPEAKSLIDSLQRWDIEAIDELPNYSRIVLRLILETIGEIEREMKPRGRSASVQHTIDETKSLGRAYLALSKWASEGYMPTFDEYMEVGEVTGGMDDFALYSFIAMEDCDEKPLYEWFDSKPKILQALSVLYRINNDIVTYEREMSKGEVVNGVNSYMNQHGVTKEEAVEELRKMARDNYKIVMEELLTITDVPRPVLVRCLNLARLFDVFCKHGNDEFTYPHGNLKDLITSIFIHPIPV
Protein: glycogenin glucosyltransferase (EC 2.4.1.186) (A0A0B4K7X5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSKFAWVTLTTNDTYSLGALVLAHSLKRAKTAHQLAVLVTPNVSQAMRDRLKEVYNVVQEVNVLDSQDAANLALLSRPELGVTFTKLHCWRLVQFEKCVFLDADTLVLQNCDELFEREELSAAPDVSWPDCFNSGVFVFKPSVDTFAQITEFAVKNGSFDGGDQGLLNQFFADWSTADIKKHLPFVYNVTAYASYCYLPAFKQFRDKIKILHFAGKLKPWLIQFNSETKVASVSSEYAHAQDLIQLWWNIFCENVIQSLSTEMCLCLNIIRTQSEFAADELHQRQQHEFYQQQKLHHHLLHVRQFRDPWADYYENLEKEPQEQEQEQQRHQHQQQHHNPSQNHSQDNGNADAAAHENDSTIANANATDWHHDDACHPPAPTRPLPQIQNQAHNANATANAEDFSFVDVNSNELNISQPPEHASYSSDTATPTATATPTATPTLTPTPHHSVHSQTVEKATSHQQEHEVAATTPPEAGLAGALSQLRIGQQRTPEQEAYENQMRRQCWESGQIDYTGADSFENIWKKISQTLERKTDKESEETGSS
Protein: Testis tissue sperm-binding protein Li 79P (A0A140VKG2)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
Sequence:
MHFQAFWLCLGLLFISINAEFMDDDVETEDFEENSEEIDVNESELSSEIKYKTPQPIGEVYFAETFDSGRLAGWVLSKAKKDDMDEEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHHAISAVLAKPFIFADKPLIVQYEVNFQDGIDCGGAYIKLLADTDDLILENFYDKTSYIIMFGPDKCGEDYKLHFIFRHKHPKTGVFEEKHAKPPDVDLKKFFTDRKTHLYTLVMNPDDTFEVLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPACRIGCGEWKPPMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYFEDDHPFLLTSFSALGLELWSMTSDIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPGVLKQLMAAAEGHPWLWLIYLVTAGVPIALITSFCWPRKVKKKHKDTEYKKTDICIPQTKGVLEQEEKEEKAALEKPMDLEEEKKQNDGEMLEKEEESEPEEKSEEEIEIIEGQEESNQSNKSGSEDEMKEADESTGSGDGPIKSVRKRRVRKD
Protein: Uncharacterized membrane protein YMR253C (Q04835)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}. Note=Localizes to cytoplasmic punctate structures.
Interaction partners:
- Efficient mitochondria targeting-associated protein 19
- Vacuolar membrane protein YPL162C
Sequence:
MNPSVPKVMKRENNTHLLVSKEMNDTSLQLPSTTRSLSPKESNSNEDFNVDGNETTLQRISKDYLKPNIGLVLLTVSYFFNSAMVVSTKVLENDPDDIANDRQIKPLQILLVRMVITYIGTLIYMYINKSTISDVPFGKPEVRKWLVLRGCTGFFGVFGMYYSLMYLTISDAVLITFLAPSLTIFLSWVILRERFTKVEALGSLISLLGVVLIVRPSFLFGTPELTDSSSQIVESSDPKSRLIATLVGLWGVLGMSCVYIIIRYIGKRAHAIMSVSYFSLITAIVSFIGINTIPSMKFQIPHSKKQWILFGNLGVSGFIFQLLLTMGIQRERAGRGSLMTYTQLLYAVFWDVALYKHWPNIWSWIGMIIIISATLWVIRIRAANNETTAKDLTPIIDDEENSIPLTEFDLSDSK
Protein: Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 4 (UDP-GlcA:xylan glucuronyltransferase 4) (EC 2.4.1.-) (Glycogenin-like protein 4) (Plant glycogenin-like starch initiation protein 4) (Protein GLUCURONIC ACID SUBSTITUTION OF XYLAN 4) (AtGUX4) (Q9FZ37)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the substitutions of the xylan backbone in stem glucuronoxylan.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Probable beta-1,4-xylosyltransferase IRX9H
- Probable glucuronoxylan glucuronosyltransferase F8H
- Probable beta-1,4-xylosyltransferase IRX14H
- Probable beta-1,4-xylosyltransferase IRX10L
- Protein IRX15-LIKE
- Probable beta-1,4-xylosyltransferase IRX10
- Beta-1,4-xylosyltransferase IRX9
- Beta-1,4-xylosyltransferase IRX14
- Probable galacturonosyltransferase-like 1
- Probable glucuronoxylan glucuronosyltransferase IRX7
Sequence:
MGTKTHNSRGKIFMIYLILVSLSLLGLILPFKPLFRITSPSSTLRIDLPSPQVNKNPKWLRLIRNYLPEKRIQVGFLNIDEKERESYEARGPLVLKNIHVPLDHIPKNVTWKSLYPEWINEEASTCPEIPLPQPEGSDANVDVIVARVPCDGWSANKGLRDVFRLQVNLAAANLAVQSGLRTVNQAVYVVFIGSCGPMHEIFPCDERVMRVEDYWVYKPYLPRLKQKLLMPVGSCQIAPSFAQFGQEAWRPKHEDNLASKAVTALPRRLRVAYVTVLHSSEAYVCGAIALAQSIRQSGSHKDMILLHDHTITNKSLIGLSAAGWNLRLIDRIRSPFSQKDSYNEWNYSKLRVWQVTDYDKLVFIDADFIILKKLDHLFYYPQLSASGNDKVLFNSGIMVLEPSACMFKDLMEKSFKIESYNGGDQGFLNEIFVWWHRLSKRVNTMKYFDEKNHRRHDLPENVEGLHYLGLKPWVCYRDYDCNWDISERRVFASDSVHEKWWKVYDKMSEQLKGYCGLNKNMEKRIEKWRRIAKNNSLPDRHWEIEVRDPRKTNLLVQ
Protein: Protein yippee-like (Protein yippee-like 3) (Q9W2X7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in regulating synaptic transmission in presynaptic neurons. In class IV dendritic arborization neurons (nociceptors), involved in regulating activation of their second-order neurons (SONs) and maintaining synaptic contact between nociceptors and their SONs.
Interaction partners:
- RE57120p
- BcDNA.GH12326
- Organic solute transporter alpha-like protein
- Ran-binding proteins 9/10 homolog
- GH10162p
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Sequence:
MVKTFQAYLPSTNRTYSCVHCRAHLASHDELISKSFQGSQGPAYLFNSVVNVACGQTEERVLLTGLHAVADIYCECCKTPLGWKYEHAYESSQKYKEGKFIIELAHMIKENGWD
Protein: Cullin-3A (AtCUL3a) (Q9ZVH4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the cullin-RING ubiquitin ligases (CRL), or CUL3-RBX1-BTB protein E3 ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the CRL complex depends on the BTB domain-containing protein as the susbstrate recognition component. Involved in embryo pattern formation and endosperm development. Required for the normal division and organization of the root stem cells and columella root cap cells. Regulates primary root growth by an unknown pathway, but in an ethylene-dependent manner. Functions in distal root patterning, by an ethylene-independent mechanism. Functionally redundant with CUL3B.
Interaction partners:
- RING-box protein 1a
- Regulatory protein NPR4
- Regulatory protein NPR3
- E3 ubiquitin-protein ligase PRT1
- NEDD8-like protein RUB3
- COP9 signalosome complex subunit 4
- BTB/POZ and MATH domain-containing protein 3
- Cullin-associated NEDD8-dissociated protein 1
- Ubiquitin-NEDD8-like protein RUB1
- COP9 signalosome complex subunit 5a
Sequence:
MSNQKKRNFQIEAFKHRVVVDPKYADKTWQILERAIHQIYNQDASGLSFEELYRNAYNMVLHKFGEKLYTGFIATMTSHLKEKSKLIEAAQGGSFLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKTHVHPMGLNLWRDNVVHFTKIHTRLLNTLLDLVQKERIGEVIDRGLMRNVIKMFMDLGESVYQEDFEKPFLDASSEFYKVESQEFIESCDCGDYLKKSEKRLTEEIERVAHYLDAKSEEKITSVVEKEMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLVTVRDVMTSHLREMGKQLVTDPEKSKDPVEFVQRLLDERDKYDKIINTAFGNDKTFQNALNSSFEYFINLNARSPEFISLFVDDKLRKGLKGITDVDVEVILDKVMMLFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSEDTMRGFYGSHPELSEGPTLIVQVLTTGSWPTQPAVPCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTNMGTADIKAIFGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPAADLKRCLQSLACVKGKNVIKKEPMSKDIGEEDLFVVNDKFTSKFYKVKIGTVVAQKETEPEKQETRQRVEEDRKPQIEAAIVRIMKSRKILDHNNIIAEVTKQLQPRFLANPTEIKKRIESLIERDFLERDSTDRKLYRYLA
Protein: Acetyl-coenzyme A synthetase 1 (EC 6.2.1.1) (Acetate--CoA ligase 1) (Acyl-activating enzyme 1) (Q01574)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. 'Aerobic' isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate.
Subcellular location: Microsome {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus.
Interaction partners:
- Citrate synthase 3, mitochondrial
- Malate synthase 1
- Citrate synthase, peroxisomal
- Magnesium-activated aldehyde dehydrogenase, cytosolic
- Aldehyde dehydrogenase [NAD
- Potassium-activated aldehyde dehydrogenase, mitochondrial
- Citrate synthase, mitochondrial
- Acetyl-CoA hydrolase
- Aldehyde dehydrogenase [NAD
- Acetyl-CoA acetyltransferase
Sequence:
MSPSAVQSSKLEEQSSEIDKLKAKMSQSAATAQQKKEHEYEHLTSVKIVPQRPISDRLQPAIATHYSPHLDGLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDSVKL
Protein: Alpha-bungarotoxin (Alpha-Bgtx) (Alpha-Btx) (Alpha-bungarotoxin, isoform A31) (Alpha-BTX A31) (Alpha-BgTx(A31)) (Alpha-bungarotoxin (A31)) (BGTX A31) (Alpha-elapitoxin-Bm2a) (Alpha-EPTX-Bm2a) (Long neurotoxin 1) (P60615)
Organism: Bungarus multicinctus (Many-banded krait)
Function: Binds with high affinity to muscular (tested on Torpedo marmorata, Kd=0.4 nM) and neuronal (tested on chimeric alpha-7/CHRNA7, Kd=0.95 nM) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission. It also shows an activity on GABA(A) receptors. It antagonises GABA-activated currents with high potency when tested on primary hippocampal neurons. It inhibits recombinantly expressed GABA(A) receptors composed of alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits with high potency (62.3% inhibition at 20 uM of toxin). It also shows a weaker inhibition on GABA(A) receptors composed of alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits, alpha-4-beta-2-gamma-2 (GABRA4-GABRB2-GABRG2) subunits, and alpha-5-beta-2-gamma-2 (GABRA5-GABRB2-GABRG2) subunits. A very weak inhibition is also observed on GABA(A) receptor composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2). It has also been shown to bind and inhibit recombinant GABA(A) receptor beta-3/GABRB3 subunit (Kd=about 50 nM). In addition, it blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4.2 uM). In vivo, when intraperitoneally injected into mice, induces flaccid paralysis of the limbs and respiratory distress, and causes death in a dose-dependent manner.
Subcellular location: Secreted {ECO:0000269|PubMed:5027709}.
Interaction partners:
Sequence:
MKTLLLTLVVVTIVCLDLGYTIVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG
Protein: Alpha-ketoglutarate-dependent xanthine dioxygenase xanA (EC 1.14.11.48) (Q4QZZ9)
Organism: Emericella nidulans (Aspergillus nidulans)
Function: Alpha-ketoglutarate-dependent xanthine dioxygenase is a non-heme mononuclear Fe(2+) enzyme that decarboxylates alpha-ketoglutarate to succinate and CO(2) while hydroxylating xanthine to generate uric acid. Allows xanthine utilization as a nitrogen source. Whereas xanA is highly specific for xanthine, alpha-ketoadipic acid can replace alpha-ketoglutarate as a cosubstrate. Exhibits ferroxidase activity in the absence of substrates.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:24970358}.
Interaction partners:
Sequence:
MPAITVKPLTPPAGSAIDFGAVITDVDLEHLTDGDFSTIRSALYTHLVVVLKNQHQLTPKAQYELTRRFDPSATQYGHGKTLDAKRSILHPDLKTIPHQPQVQVIGHGFIDSYEGLENITLKHPHHRTFHRDPIPQEDDYDSTRFYRWHIDAALYGLNPPIVTTLLAVKVPGGRRQTVRYDDGSGETMDVPLGTTAFASGERMFELLSEEDKEFALSSRVEYAPHPYIWMSPARSLPTGLGLHSDDLELPLSELPPIDESAIQILPMVWKNPATGKPALQIHPSAVRKIHCGDGTVIDDLKKVREIAYKLQRPAISPQYVYAHDWEEGDLVLFHNRGVLHSVVGAFGEGEVRLFRQCNLAAGEGVVPYRE
Protein: GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (Adenylate kinase 3 alpha-like 1) (Adenylate kinase isozyme 3) (P29411)
Organism: Rattus norvegicus (Rat)
Function: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q9UIJ7, ECO:0000255|HAMAP-Rule:MF_03169}.
Interaction partners:
- Adenine phosphoribosyltransferase
- Adenylosuccinate lyase
- Ribonucleoside-diphosphate reductase
- Nucleoside diphosphate kinase, mitochondrial
- Adenosine kinase
- Nucleoside diphosphate kinase 6
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase B
- ribonucleoside-diphosphate reductase
- Nucleoside diphosphate kinase A
Sequence:
MGASGRLLRAVIMGAPGSGKGTGSSRITKHFELKHLSSGDLLRQNMLQGTEIAVLAKSFIDQGKLIPDDDMTRLALHELKNLTQCSWLLDGFPRTLPQAEALDRVYQIDTVINLNVPFEVIKLRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTETNKIRPHVYSFLQMKVPETIQKASVTP
Protein: Pecanex-like protein 2 (Pecanex homolog protein 2) (A6NKB5)
Organism: Homo sapiens (Human)
Function: May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MVSQVLQLLRQGVWAALTGGWYHDPEQSKFTNSCHLYLWLFLLLLPLALHLAFPPNAIIVFFYCSAVTIFFTIIKLVSYRLHLMFDKGEVIQQKPSRKEEKPNKDKEAKGEHITNHRNPSNNRQIHNGKKEEASRNLSTPPLRCSSRGQSITSHHSSGPLELSAQETVEDLKGVILLEDHPIAPVSSTSPGIKVESLPASQAHMLETTTKSVIPVKPVATETLINGKGKERGGKGQPPLRHRSEGGLVDKGPLKKLPHLSLSQYDLLETDVSFQPWGSENSVLIPEPVSCPRGSIRERVQSKSPQDSLSSSCPQCDTIVAKPVEEPADTSCQVDTSCQGDLPLHQEVDSSDSEVAVTLIDTSQPGDPLSLHEPIKIVITMSSTPNSMTDLESSLHLRVVGTEKTSVKSDAEPTNPGAAGSPNAEQISIPVITLDLPEGGGGGVPCPEGNGSERTPERLKTRVSTNQCSGYGSGEGGNAIKDHSSSSREPWESVSRLTPDTGSESKVGKEGQTNLDPSSCKSSHEKRHARVLSVDSGTDVFLSKSSAEIVNDTEKTMPTSKSDLEAKEGQMPNESNFLEFVSLLESINTSKMTASSQLNGSAEQNEESGLLRDNCSQEKKEEILENEKPSGHSSKQGKPDLQSQDHTSTGPACTQPAKTTAFFQGNRQRQIIYRVTSQQDSSVLQVISGPETSVQEEISVDAMHVFIDEHGEIRSCYLKSGNQKEGPLQPLPSNNDCLSQAREMQVSSSSTTTSESQDPSSGDPAVSALQQQLLLMVARRTQSETPRHVSQDLEASSCSSTQGKFNREQFYKFIIFPGKWIKVWYDRLTLLALLDRTEDIKENVLAILLIVLVSLLGFLTLSQGFCKDMWVLLFCLVMASCQYSLLKSVQPDPASPIHGHNQIITYSRPIYFCVLCGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIVFLYCFPAISLLGLFPQINTFCTYLLEQIDMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCFSAVKEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAASQATRHLSEPCEPPDATEQGQLHDRCLAEAVADTLGVVCRRASQEDMGLDDTASQQSVSDEQ
Protein: Uncharacterized protein (Q57U03)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGSGCSTESSTDVRCSFVGLMDEKKESWRGRLLGDIGKDPTGVTRDFPRTQVYVAAPNRNNYYREKQDHVSVLVLKDKEDESKYFSDRNERVRESLELLVELCGEDSSVIKSEWEKQQKDIPDSSSLLMTVLLESGMMRATEANTENGGAGGETDAVTNIQNGGGGYAPKYTVHSKALRLMQYMVQSVAFFSTQHVTDALRFSWCKHMQDVSWAVYVYTEGGACGKERNSSDEILVLRHMHTLRHYVGQSERSTHPRFEVDWACTFHIDLKRLLDANNTAAKEATFAPEGEVQRIDGELLAARIESPNRKLCRITSTWKKRRSELEGRLMECFGVELTKVDVLDENGPLSALNSGG
Protein: Mesoderm posterior bb (Mesp-bb) (I2AVW0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Protein ripply1
- Hairy and enhancer of split-related-7.
Sequence:
MDASSPFFNYIQQNSWSSDSELYNISSPETVSPSSYMDFSPSAQAQSVSPKPEISGSSFQDGGRSRVGVRRTRCKNPSKQRQSASEKEKLRMRDLTKALHHLRTYLPPSVAPVGQTLTKIETLRLTIRYISYLSAQLGLSEESLCKMRDLRVSGYQEMPQNHCYSTAEFWGSCQNSCGTSESVLRRTDMDCRQVFMGMEKPAYDDSFNSSSESLLESPLYADSALTYQGYNKGVHCSIAPEFWG
Protein: histidine kinase (EC 2.7.13.3) (C8V8F5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Histidine-containing phosphotransfer protein
- Mitogen-activated protein kinase hog1
Sequence:
MACADETLTAAAAIIQNLVREAPSSGSPSFEFNFSPQSTNGVDSLPKLPGEPSLAKVRFENELEALVRRIHRMEVQSQQNHTQHAEHTQHLHKRRKSSKDTEPEILDESDGAASDEDEEEGATTLVREEDISYLRNYVQKQAEEISFQKNIITQVREELQLQEVQTRRALTKVENEDVVLLERELRKHQQANEAFQKALREIGGIITQVANGDLSMKVQIHPLEMDPEIATFKRTINTMMDQLQVFGSEVSRVAREVGTEGILGGQAQITGVHGIWKELTENVNIMAKNLTDQVREIAVVTTAVAHGDLSQKIESRAQGEILELQQTINTMVDQLRTFATEVTRVARDVGTEGVLGGQAQIEGVQGMWNELTVNVNAMANNLTTQVRDIATVTKAVAKGDLTQKVQANCKGEIAELKNIINSMVDQLRQFAQEVTKIAKEVGTDGVLGGQATVNDVEGTWKDLTENVNRMANNLTTQVREIADVTTAVAKGDLSKKVTANVQGEILDLKSTINGMVDRLNTFAFEVSKVAREVGTDGTLGGQAKVDNVEGKWKDLTDNVNTMAQNLTSQVRSISDVTQAIAKGDLSKKIEVHAQGEILTLKVTINHMVDRLAKFATELKKVARDVGVDGKMGGQANVEGIAGTWKEITEDVNTMAENLTSQVRAFGEITDAATDGDFTKLITVNASGEMDELKRKINKMVSNLRDSIQRNTAAREAAELANRTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDDLKPYTREMLNVVHNLANSLLTIIDDILDISKIEANRMVIESIPFTVRGTVFNALKTLAVKANEKFLSLTYQVDNTVPDYVIGDPFRLRQIILNLVGNAIKFTEHGEVKLTICKSDREQCAANEYAFEFSVSDTGIGIEEDKLDLIFDTFQQADGSTTRRFGGTGLGLSISKRLVNLMGGDVWVTSEYGHGSTFHFTCVVKLADQSLNVIASQILPYKNHRVLFIDKGENGPEAENVLKMLKKLDLEPLVVRNEDHVPPPEIQDPSGKESGHAYDVIIVDSVNTARMLRTYDDFKYVPIVLVCPLVCVSLKSALDLGISSYMTTPCEPIDLGNGMLPALEGRSTPITTDHSRSFDILLAEDNDVNQKLAVKILEKHNHNVSVVGNGLEAVEAVKQRRYDVILMDVQMPVMGGFEATGKIREYERDSGLSRTPIIALTAHAMLGDREKCIQAQMDEYLSKPLKQNQMMQTILKCATLGGSLLEKSKESRISSSGEMHHVHTGPDGKSQRPGMEGRSITSSSATSRTLASTSAERTEQLSIDRVRP