wanglab/gogpt-training-data huggingface dataset:
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) (O15072)
Organism: Homo sapiens (Human)
Function: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.
Subcellular location: Secreted {ECO:0000269|PubMed:28985353}. Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Aggrecan core protein
- Collagenase 3
- Stromelysin-1
- Collagen and calcium-binding EGF domain-containing protein 1
- Collagen alpha-1
- Interstitial collagenase
- Furin
- Metalloproteinase inhibitor 1
- Collagen alpha-1
- Fibronectin
Sequence:
MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRSSTLER
Protein: BBSome complex member BBS7 (BBS2-like protein 1) (Bardet-Biedl syndrome 7 protein) (Q8IWZ6)
Organism: Homo sapiens (Human)
Function: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
Subcellular location: Cell projection, cilium membrane {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}. Cytoplasm {ECO:0000269|PubMed:22072986}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:22072986}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8K2G4}.
Interaction partners:
- BBSome complex member BBS1
- Tetratricopeptide repeat protein 8
- BBSome complex member BBS5
- Protein PTHB1
- BBSome complex member BBS4
- BBSome complex member BBS2
- Chaperonin-containing T-complex member BBS12
- BBSome complex assembly protein BBS10
- Leucine zipper transcription factor-like protein 1
- Rab-3A-interacting protein
Sequence:
MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKTLPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSDLFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDVMYAVEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRGGILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGKDSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQERENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALISFFDAA
Protein: Uncharacterized protein At2g27730, mitochondrial (Q9ZUX4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11743114, ECO:0000269|PubMed:14671022, ECO:0000305|PubMed:25732537}.
Interaction partners:
- Excitatory amino acid transporter
- Gamma carbonic anhydrase 2, mitochondrial
- At4g16450
- Gamma carbonic anhydrase 1, mitochondrial
- 2Fe-2S ferredoxin-like superfamily protein
- NADH dehydrogenase 1 beta subcomplex subunit 8
- Transmembrane protein
- NADH dehydrogenase 1 beta subcomplex subunit 10-B
- NADH dehydrogenase 1 beta subcomplex subunit 3-B
- NADH dehydrogenase 1 beta subcomplex subunit 7
Sequence:
MATRNALRIVSRRFSSGKVLSEEERAAENVFIKKMEQEKLQKLARQGPGEQAAGSASEAKVAGATASASAESGPKVSEDKNRNYAVVAGVVAIVGSIGWYLKAGGKKQPEVQE
Protein: ATP-dependent rRNA helicase rrp3 (EC 3.6.4.13) (Q9P6N8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Uncharacterized protein C3B8.09
- Pre-rRNA-processing protein esf1
- Uncharacterized protein C18B11.06
- Probable U3 small nucleolar RNA-associated protein 7
- rRNA biogenesis protein rrp5
- ATP-dependent RNA helicase rok1
- KRR1 small subunit processome component homolog
- Probable nucleolar complex protein 14
- ATP-dependent RNA helicase dbp8
- U3 small nucleolar RNA-associated protein 25
Sequence:
MAPSEKKLTEDKKNSSLNKKIETSNSSSEKSSENNNGDSQNNEAPKTFKELGVIDELCEACEKLGFKTPTPIQQEAIPVVLNKRDVIGLAQTGSGKTAAFALPVIQELWNNPSPFFAVVLAPTRELAYQISEQFEAIGGSIGVRSVVIVGGMDMVTQAVALSKKPHVLVCTPGRLMDHLENTKGFSLKNLKYLIMDEADRLLDMDFGPIIDKILKIIPHERRTLLFSATMTSKVEKLQRASLHQPVRVAVSSKFSTVDTLIQRYLFFPFKHKDTYLVYLVNELAGNSIIIFARTVNDTQRLAILLRTLGFSAIPLHGQLSQSNRLGALNKFKSGARSTLVATDVAARGLDIPLVDVVINYDIPTDSKAYIHRVGRTARAGRAGKSIALVTQYDLEPFLRIEATIGKKMQEYEIDKEGVFLLSERVGEAQREAIIQMKEIHDRRKSKGKLHTKRKRDDLDREEQIY
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q6V9V9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Programmed cell death protein 10
- Striatin
- Striatin-interacting protein 1
- Striatin-4
- non-specific serine/threonine protein kinase
- Striatin-3
- Striatin interacting protein 2
- Serine/threonine-protein kinase 24
- MOB-like protein phocein
- Suppressor of IKBKE 1
Sequence:
MAHLRGFAHQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPTLEGHHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPIKRQPRSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHSRNHLTSTR
Protein: Sulfhydryl oxidase (EC 1.8.3.2) (A4QNU9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Mitochondrial intermembrane space import and assembly protein 40
- Coiled-coil-helix-coiled-coil-helix domain-containing 4b.
- Mitochondrial import inner membrane translocase subunit TIM50
- Cytochrome c oxidase copper chaperone
- Mitochondrial inner membrane protease ATP23 homolog
- Mitochondrial import inner membrane translocase subunit Tim10
- Iron-sulfur clusters transporter ABCB7, mitochondrial
- Cytochrome c
- Coiled-coil-helix-coiled-coil-helix domain-containing 10
- Mitochondrial import inner membrane translocase subunit Tim13
Sequence:
MAAAHGSSPHSSAGMEGFPFPVAGKPPEDSTSNDQTTTGETKKKPCRACTDFKSWMKLQKQASSASVQESRPVEELKPVECPLDREELGRSSWSFLHTMAAYYPDAPSTEQQLEMTQFINLFSKVFPCDECAEDLRTRLKTNRPDAGSRHKLSQWLCRLHNDINIRLGKPEFDCSRVDERWRDGWKDGSCD
Protein: Small ribosomal subunit protein eS7 (40S ribosomal protein S7) (Q10101)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL13
Sequence:
MSALNKIVKRSSSQPTETDLLVAQCLYDLESSSKDMAKELRPLQITSAREVEVGGGKKAIVVFVPQPLLKAFHKCQARLTRELEKKFADRHVIFIAQRRILPKPGRKSRVTQKRPRSRTLTAVHNAILEDIVFPTEIIGKRTRQATDGRKTIKVFLDNRDANTVDYKLGSFSSVYHKLTGKNVTFEFPVATGEGL
Protein: CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1) (Q92600)
Organism: Homo sapiens (Human)
Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250|UniProtKB:Q9JKY0}.
Interaction partners:
- CCR4-NOT transcription complex subunit 6-like
- CCR4-NOT transcription complex subunit 7
- CCR4-NOT transcription complex subunit 4
- CCR4-NOT transcription complex subunit 8
- CCR4-NOT transcription complex subunit 2
- CCR4-NOT transcription complex subunit 3
- CCR4-NOT transcription complex subunit 6
- CCR4-NOT transcription complex subunit 11
- CCR4-NOT transcription complex subunit 1
- CCR4-NOT transcription complex subunit 10
Sequence:
MHSLATAAPVPTTLAQVDREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQEGQVTDPRGIPLPPQ
Protein: Steroid-phosphate phosphatase (EC 3.1.3.-) (Protein UBASH3A homolog) (Q22323)
Organism: Caenorhabditis elegans
Function: Phosphatase that dephosphorylates some steroids such as ecdysone 22-phosphate (E22P), 3-epi-ecdysone 22-phosphate (E22P) and 3-epi-ecdysone 2-phosphate (E2P) in vitro. Also displays acid phosphatase activity towards 4-nitrophenyl phosphate (pNNP) in vitro. Has no activity towards 3-epi-ecdysone 3-phosphate (E3P) in vitro.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17348005}.
Interaction partners:
Sequence:
MPERRVFIIRHGERCDFAFGKSGLWINSFDSRGRYRPLDINLPRTLPKRADGWQGFAADTPLTEIGYLQSKLTGRALRDNGIEINHVFCSPALRCIQTTVGLLKGMGLDKRIQFSVEPGLYEWMVFARYARPCWIPPKDLKKLGYPVQENYVPCWTDKELRMNETLADFYQRSFGSINKILSECTEGNILIVAHGASLETCTRQLVGGDIRSTDDFYYLLQNTPYLSCVEVNSREGLWRLVGSPIPSFSHTYNRTFDPLQLVTKDLASLKREREGKDNMRTTQ
Protein: Dolichol-phosphate mannosyltransferase subunit 3 (Q1LXA2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365085}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365085}.
Interaction partners:
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Dolichol-phosphate mannosyltransferase subunit 1
- Dolichol kinase.
- SMAD family member 9.
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- Dolichyldiphosphatase 1.
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.
- Mannose-1-phosphate guanylyltransferase regulatory subunit alpha-B
- Protein O-mannosyl-transferase 2
Sequence:
MTKLLQWLLAVSLIGIAWGLVTFDLLDLHLLPQYKELAWPMPVYLLVVFGCYSLATVGYRVATFNDCEDAAKELQAQIKEAKEDLRKKGLKM
Protein: Cytochrome b6-f complex subunit 8 (Cytochrome b6-f complex subunit PetN) (Cytochrome b6-f complex subunit VIII) (P83798)
Organism: Mastigocladus laminosus (Fischerella sp.)
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Subcellular location: Cellular thylakoid membrane {ECO:0000305|PubMed:14526088}; Single-pass membrane protein {ECO:0000269|PubMed:14526088}.
Interaction partners:
Sequence:
MEIDVLGWVALLVVFTWSIAMVVWGRNGL
Protein: Pre-mRNA-splicing factor cwf3 (Complexed with cdc5 protein 3) (Q9P7R9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in pre-mRNA splicing and cell cycle progression.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Pre-mRNA-splicing factor cwf4
- Pre-mRNA-splicing factor cwf7
- Pre-mRNA-splicing factor cwf14
- Pre-mRNA-splicing factor spp42
- Pre-mRNA-splicing factor cwf5
- Pre-mRNA-processing factor 17
- Pre-mRNA-processing protein 45
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor syf2
- Pre-mRNA-splicing factor cwf12
Sequence:
MGDVIPLKVNFDLINVDDEPFELELLRDPYSLKSWLRYIKTHEGSTLEKRVLLFERACSELPGSYKIWKSYLELRVAHVEHLNPYFHAEAFASVNDCFERSLILLHKMPVIWKLYLQFLMKQPNVTKIRCTFNSALRALPVTQHDDIWDMFTKYAEDIGGLFCIHVYRRYIQVEPRAIENYIEILCKLGLWNEAARQYEDILNRPVFLSAKRKSNYQIWLEFSELVVQHPDHTQNIDVEKVFRAGIKRFSDQAGKLWTYLAQYYIRIGDYEKARSTFYEGMNNIMTVRNFTIIFDAFVEFEEQWLSARVEASSGNANDELSIDFHMAWLEKILDKRPLYINDVLLRQNINNVDEWLRRVKFLEDDSEKVVQVYTDAIKNVNPKLAHGSLGKLFSEFARFYENFDDLEQSRIIFEKATHVPYKTVNELAQVWIDWAEMELRHQNFDAARKLIGDAVHAPRKSHISFFDESLSPQVRLHKSSKIWMYYLDLEESVGTIETTRKLYDRVFELKIATPQVVVNYANLLEENAYFEDSFKIYERGVALFSYPVAFELWNLYLTKFVKRYQGTHMERTRDLFEQALEGCPPEFSKSIYLLYADFEEKFGKAKRSISILEKAADKVKTADRLAIYNVLLVKVALNYGVLATRTVYEKAIESLSDSEVKDMCLRFAEMETKLGEIDRARLIYIHGSQYCDPRVETDYWKAWQEFEIRYGNPEETVKEMLRIKRSVQTKFSTDSLHIAKRAAKIESAAAPMDPMEQLEMEKSEGPKALAGFVLSKSNPQETSKITGEEN
Protein: Homogentisate 1,2-dioxygenase hmgA (EC 1.13.11.5) (Homogentisate oxygenase hmgA) (Homogentisic acid oxidase hmgA) (Homogentisicase hmgA) (L-tyrosine degradation gene cluster protein hmgA) (Pyomelanin biosynthesis cluster protein hmgA) (Q4WHT9)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Homogentisate 1,2-dioxygenase; part of the L-tyrosine degradation gene cluster that mediates the biosynthesis of the brownish pigment pyomelanin as an alternative melanin. The 4-hydroxyphenylpyruvate dioxygenase hppD catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisic acid (HGA). The protein hmgX is crucial for this conversion and thus, probably functions as an accessory factor to mediate specific activity of hppD. The homogentisate 1,2-dioxygenase hmgA is then involved in the cleavage of the aromatic ring of HGA and its conversion to 4-maleylacetoacetate. When hmgA activity is lowered by the cell wall integrity (CWI) signaling pathway, HGA accumulates and leads to the production of pyomelanin through benzoquinone acetic acid after oxidation and polymerization. On the opposite, in non-stress conditions, both hppD and hmgA activities are balanced and HGA is degraded into 4-maleylacetoacetate. 4-maleylacetoacetate is further converted to 4-fumarylacetoacetate by the maleylacetoacetate isomerase maiA, which is degraded into fumarate and acetoacetate by the fumarylacetoacetase fahA (Probable).
Interaction partners:
- 4-hydroxyphenylpyruvate dioxygenase
- Maleylacetoacetate isomerase maiA
- Probable 4-hydroxyphenylpyruvate dioxygenase 2
- Fumarylacetoacetase fahA
- 4-hydroxyphenylpyruvate dioxygenase, putative
- 4-hydroxyphenylpyruvate dioxygenase, putative
- 4-hydroxyphenylpyruvate dioxygenase, putative
- homogentisate 1,2-dioxygenase
- Fumarylacetoacetase
- 4-hydroxyphenylpyruvate dioxygenase, putative
Sequence:
MPVTQFSHPDPYSYQTGFDSYHETEAVKGALPVGQNSPQKAPYGLYAEKLSGTAFTAPRHENKQTWVYRILPAAAHENFKAEDADSYHTSMTTETHKLHHIPNQLRWDPFDLDETVDWVHGLHLVAGAGDPTLKHGLGIILYAAGKDMGKEAFYSADGDFLIVPQHGVLDIQTELGRLMVRPNEICVIPRGVRYRVTLPAGPVRGYICELYQGHYQLPELGPIGSNCLANARDFQAPVASFEDEEEPTEWRLYSKFNNTLFSARQDHTPFDIVAWHGNYYPYKYDLGRFNTIGSISFDHPDPSIFTVLTGPSDHAGTAIADFVIFPPRWLVAENTFRPPWYHRNTMSEFMGLICGNYDAKTGGGFQPAGASLHNVMSAHGPDADAFEGASNAELKPQKVGDGSMAFMFESCLMVGVSEWGLKTCQKVQEQYNEHSWRPLKRHFKNPNKA
Protein: Rhodanese-like domain-containing protein 15, chloroplastic (Protein DARK INDUCIBLE 1) (Senescence-associated protein 1) (AtSEN1) (Sulfurtransferase 15) (AtStr15) (Q38853)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:15181206}. Thylakoid {ECO:0000269|PubMed:15181206}. Note=Associated with membrane.
Interaction partners:
- Asparagine synthetase 1
- Small ribosomal subunit protein mS29
- Probable galactinol--sucrose galactosyltransferase 6
- SNF1-related protein kinase regulatory subunit beta-1
- 2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial
- Protein OXIDATIVE STRESS 3
- Large ribosomal subunit protein mL46
- SNF1-related protein kinase regulatory subunit beta-2
- Nematode resistance protein-like HSPRO2
Sequence:
METTAFNTTSRIGNWSSAISPPLQTCGSFKCQLPTRRGVIVADLRNSNFRWRKATTTSRGNVAAEAVKIPTSVPVRVARELAQAGYRYLDVRTPDEFSIGHPTRAINVPYMYRVGSGMVKNPSFLRQVSSHFRKHDEIIIGCESGQMSFMASTDLLTAGFTAITDIAGGYVAWTENELPVEE
Protein: Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (tRNA-histidine guanylyltransferase) (Q54E29)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Probable histidine--tRNA ligase, mitochondrial
- Histidine--tRNA ligase, cytoplasmic
- Inosine triphosphate pyrophosphatase
- DNA topoisomerase 2, mitochondrial
Sequence:
MANSKYEYVKSFEQPDILLQNVWIVVRIDGRSFHKFTTKHDYAKPNDDRGLSLMNRAALEVCKEFPDIVIAFGESDEYSFVLKKSCNLFERRSSKISSSIVSYFTSQFVYRWKEYFGEHELKYPPTFDSRCVLYPTDENIKDYLSWRQADTHINNLYNTCYWALVLKAGKTPIEAENELRGTFSDGKNEMLFSRFNINYNNLPAEYRKGSVIFKKPVQETNKETGLTKSKKRLVIEHVDIISEKFWKEYPDILASK
Protein: Sterile alpha motif domain-containing protein 12 (SAM domain-containing protein 12) (Q8N8I0)
Organism: Homo sapiens (Human)
Interaction partners:
- Rap guanine nucleotide exchange factor 2
- StAR-related lipid transfer protein 7, mitochondrial
Sequence:
MAVEALHCGLNPRGIDHPAHAEGIKLQIEGEGVESQSIKNKNFQKVPDQKGTPKRLQAEAETAKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQHILQQVLQLKVREEVRNLQLLTQGTLLLPDGWMDGEIRRKTTLLLGQTGVRENLLLFLHRISIIENSIQI
Protein: Putative polyol transporter 1 (Q9XIH7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plasma membrane sugar-proton symporter.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- rRNA methyltransferase 2
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- tRNA
- DNA
Sequence:
MNSSGVEQGVVIAESEPPRGNRSRYAFACAILASMTSIILGYDIGVMSGASIFIKDDLKLSDVQLEILMGILNIYSLVGSGAAGRTSDWLGRRYTIVLAGAFFFCGALLMGFATNYPFIMVGRFVAGIGVGYAMMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYFFSKLPEHLGWRFMLGVGAVPSVFLAIGVLAMPESPRWLVLQGRLGDAFKVLDKTSNTKEEAISRLDDIKRAVGIPDDMTDDVIVVPNKKSAGKGVWKDLLVRPTPSVRHILIACLGIHFAQQASGIDAVVLYSPTIFSKAGLKSKNDQLLATVAVGVVKTLFIVVGTCVVDRFGRRALLLTSMGGMFLSLTALGTSLTVINRNPGQTLKWAIGLAVTTVMTFVATFSIGAGPVTWVYCSEIFPVRLRAQGASLGVMLNRLMSGIIGMTFLSLSKGLTIGGAFLLFAGVAAAAWVFFFTFLPETRGIPLEEMETLFGSYTANKKNNSMSKDNEVVDGQ
Protein: ESX-4 secretion system protein eccD4 (ESX conserved component D4) (Type VII secretion system protein eccD4) (T7SS protein eccD4) (P9WNQ1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- ESX-4 secretion system protein EccC4
- Mycosin-4
- Hypothetical alanine and valine rich protein
- ESX-5 secretion system ATPase EccB5
- ESX conserved component EccC2. ESX-2 type VII secretion system protein. Possible membrane protein
- Outer membrane channel protein CpnT
- ESX-3 secretion system ATPase EccB3
- ESX-3 secretion system protein EccC3
- ESX-5 secretion system protein EccC5
- ESX-3 secretion system protein EccE3
Sequence:
MPTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDRGASPATAARYQLSALGAPALPNATTLAQCGIRDGAVLVLHKSSAQPPTPRCDDVAEAVAAALDTTARPQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAAGLAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVLVAAMAAAATSVLAMRITGCGGITLTAVACCAVVVAAATLVGAITAAPVPAIGSLATLASFGLLEVSARMAVLLAGLSPRLPPALNPDDADALPTTDRLTTRANRADAWLTSLLAAFAASATIGAIGTAVATHGIHRSSMGGIALAAVTGALLLLRARSADTRRSLVFAICGITTVATAFTVAADRALEHGPWIAALTAMLAAVAMFLGFVAPALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLDLTWT
Protein: Signal transducer and activator of transcription 5A (P42229)
Organism: Homo sapiens (Human)
Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15534001}. Nucleus {ECO:0000269|PubMed:15534001}. Note=Translocated into the nucleus in response to phosphorylation.
Interaction partners:
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
- Epidermal growth factor receptor
- Signal transducer and activator of transcription 3
- Interleukin-2 receptor subunit alpha
- Receptor tyrosine-protein kinase erbB-4
- Erythropoietin receptor
- Crk-like protein
- Interleukin-2 receptor subunit beta
Sequence:
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS