wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (Q38A01)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
- Polyubiquitin, putative
- Ubiquitin-like modifier-activating enzyme 5
- E3 ubiquitin-protein ligase
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-conjugating enzyme E2, putative
- E2 ubiquitin-conjugating enzyme
- Ubiquitin fusion degradation protein 2, putative
- E2 ubiquitin-conjugating enzyme
- Ubiquitin-conjugating enzyme E2, putative
Sequence:
MDEETTFPPQQQGKALISELRSVVNDYRNRKTVEAREKIIAAMDNTCASLCFGDEGFIRNLNPCSLASALVAVLTSTLATDYPEVQCLAVQALALVADLVPRGGFAVVAARGVQPLLLLLKELDASESTTLEELLRCLTNLAFEAHEQLMQHQAFSVIVSIERRLETHRLRMMCLKCLSHLLTLTSPEEWNIYLSKPCSSLMATFHEAVTRLMKDDCAGDRLSKDDEAYLLRLLECVALTFDRVLCSAKMIDRNSRMVEQLVSSLVVVINGAASMGSRGTALRNAACSPLLTLLFTDPAVTVRIFLKCHVLDSIYSNISGLLEKRPKQASYNGAAVISALMEEDLTAVPSVAEEQKVIPLLEFLLVVMPPSCTASDCDYYTTLPHYIWQWEDDFHNWCDCTEDLSKRLEGEYIKQRRLSGYTVFEVSNATSTLKINFSTMRYRSSESLHYPHNISRRPSIAGYIYRRPIRCQCDVKVTPNSSLPVEVALGRLVSLGAGTTTVLDGEPAVVSAGVPTGNAHSNEQSYCESASYSFGNIAAPSSSNQPSRGHGAHNGGVVEERGSHCCCVSVLRSLFRKLKGSGRSTAVPEAGKYGAGSALTSYEVLDDVRVELLRCAATRSNFLQERMIYRIIQQYLPILMRVVDSTANLIIVRHCSVLILRCVDLVIGYFRSGGRDQGQPTRTLWGLFCALGPSLATSLSYLTTSSTTHGSLTLSAAPFREFRCGSAFVLALSALDVTVGTRLPAMNLACETQLTSLSALMMLCSLCPIGVKALTKQQSLALLWKLERITGPAERSSQGGVHLLLEGHRVPPCPFHTKALQIEELRRTLVQQLCSLLWTNARAVDQMLPFKKCCLDISGDDQQDSQLGDSVAMGSPEGSVSPSASCTSLTYISSSGDLDGDTPRSRSTQVIKRLTRINEYMKEHSNDLPVFLYDQPELLKDLASALRSADVREVIGSKMNEVFSQLIKSLLRTICKYTGIGRLEEPRAVERQYSRFQRRTRRNRTMLMVVDYLWTPLRVNLVNTPVQAGKKRSLSKFFRLQKDSTNAADAGSPNAQVRESVLSVLPTTPLSYIAKYIIMRLNEACNNTCDPKSEDAEQQRQQELAEESNFGATLAHQEAADTPVGVNGGVGEETALGGNVINFLNRRESRLSDASDADDEESVTSGDASEFSEGRDGDYLSEHVLSTVSATVSMVPQAPSNICSGPLGGLRASQVEGSTSTTITIDNVVFFCGGKPVTDLSISVLDLCGSSYCQASGWSDLHQSDSDENCGDNAPVRHTSGERLHYLMKNVLSLWSSVHTINYSIVGMRANEERRGTDGEEVLDMNENSPVEVFSRLSYSPRGTPFLWAAADLLNEMGQLVRAAGGALSMDDPLVSSALFHEFYNHFGVLMLPALAYGIIHAYLADQQDRYLISSVLWKYPQTFSYEIRRTLLHLLLSVRRIHTPAIVKLKEWASGSSPIPPVQGLEWLRPDLNMRGTYRVRVQRFNIFESGARVLRRHAMCPLTLSVEFENELGVGAGPAVEFYNLLARKFQDVQLHMWRTEEFTDESAKTARRVQLPLFPSLFQDDESLSNFELLGMLVGRVLMEERVVDLPLSECFLRGILGDLDDTNRLPYIDPQLDKQLDSLLKLTANELEECELMFVIQHGDAEHNGGIVELCPNGATTQVSAMNVNEYVQEVRRYYSKTALARPVSHFIQGLRYTLIPYHLRLFDARELQLVISGPEGKIWESAGDLLTVITTNHGYDKNSLVVAYFVEVVSSWDVSLQRSFLRFVTGSTRIPIGGLRPPITVVRRSVEVAPGEATNQLDTTNNFLMDDRAEVLQNLMDASLPTVNTCAHYLKLPNYSSKKILEERLKLAITEGQGTFSLT
Protein: Solute carrier family 38 member 6 (Amino acid transporter SLC38A6) (G3UVW3)
Organism: Mus musculus (Mouse)
Function: Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24752331}; Multi-pass membrane protein {ECO:0000255}. Synapse. Note=Colocalizes with synaptotagmins and SNAP25. {ECO:0000269|PubMed:24752331}.
Interaction partners:
- Nocturnin
- Rab3 GTPase-activating protein catalytic subunit
Sequence:
MQASRHSIQAEPGWYVSAQQPEEAVAADEWSPLLSNEPHRQGSSGASFGLSVFNVMNAIMGSGILGLAYVMANTGILGFSFLLLFVALLASYSVHLLLAMCIHTAVTSYEDLGLFAFGLPGKVVVAGTIIIQNIGAMSSYLLIIKTELPAAISEFLPSDHSGSWYLDGQMLLIIICVGIVFPLSLLPKIGFLGYTSSLSFFFMVFFALVVVIKKWAVPCPVTLDCINEVFQISNATDDCKPKLFHFSKESVYAIPTMAFSFLCHTSVLPIYCELQSPSKKRMQNVTNTAIALSFLVYFVSALFGYLTFYDKVESELLQGYSKYLPHDVIVMAVKLCILFAVLLTAPLIHFPARKALMMILFSNYPFSWIRHSLTTAALNAIIVVLAIYVPDIRNVFGVVGASTSTCLIFVFPGLFYLKLSREDFLSWKKLGALFLLLTGAVVGSFSLVLIIFDWVNK
Protein: UMP-CMP kinase 2 (EC 2.7.4.14) (Deoxycytidylate kinase 2) (CK 2) (dCMP kinase 2) (Uridine monophosphate/cytidine monophosphate kinase 2) (UMP/CMP kinase 2) (UMP/CMPK 2) (Q20230)
Organism: Caenorhabditis elegans
Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03172}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03172}.
Interaction partners:
- Ribonucleoside-diphosphate reductase large subunit
- dUTP diphosphatase
- Uracil phosphoribosyltransferase homolog
- Uroporphyrinogen-III synthase
- Uridine kinase
- Nucleoside diphosphate kinase
- Uridine 5'-monophosphate synthase
- Probable uridine-cytidine kinase
- Ribonucleoside-diphosphate reductase small chain
- Thymidine kinase
Sequence:
MHNVVFVLGPPGSGKGTICAKIQENLNYVHLSAGDLLRAERQREGSEFGALIESHIKNGSIVPVEITCSLLENAMKACGDAKGFLVDGFPRNEDNLQGWNKQMDGKALVQFVLFLSCPVSICIERCLNRGQGRTDDNEESLKKRVETYNQQTFPIIEHFEKSGLVREVKSERPVDVVYADVEKVFDAANKK
Protein: NADH-ubiquinone oxidoreductase complex I subunit (Q38BI7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004443}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004443}; Matrix side {ECO:0000256|ARBA:ARBA00004443}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Uncharacterized protein
- NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial
- Peptidyl-prolyl cis-trans isomerase
- NADH-ubiquinone oxidoreductase complex I subunit
- NADH-ubiquinone oxidoreductase complex I subunit
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Adrenodoxin reductase, putative
Sequence:
MRSSQFLLSGLRRTAILMTISDEYIPRAFPVKSTTGLAGIAVEPLWKPKLLAAASELQAFLTSSDIPPESTYYNIAMTLVKRVNHGIKECQDDWCTLEKRYFWGWPVEYILQVTWRELETAQKWNEWRFWELDPEQVKKVAREDQNIGREGLGYNSPWEQVVREDFDKRKKALTQEEMAELKRMDTERMARETAAYKERKDRIRDDLEKARGDMLKKFLNKRFAVDKDLQRMQPGKRYSGKTADDLIAELKSSVENNPQKSDLGK
Protein: GTP-binding protein (Q0P4E7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Prostaglandin D2 synthase b, tandem duplicate 2
- Lipocalin-type prostaglandin D synthase-like protein
Sequence:
MTLLASVRRHSIRVQHHLHRWSICGTDGGQLLNDAFPRSDISMSRSSSCSSASSDSALSTESATPASVGPFTVVLLGDNGVGKSALASIFAGASDSMGSECELYGGEIFEQTITVDGERASVTLLDTWDSQDEGSWTQQRCLQTGDAFIIVYAITDRSSFLRASDLRVQLRREREVDRTPIILVGNKCDLVRCREVSISEGRSSAAVFDCKFIETSAAMQHNVWPLFEGIIRQLRLRRDSMETLSSHSSLQKRRESLPKKAKRFINRMVAKKNKQAAFKLKSKSCHDLMSL
Protein: Stevor (C6KTF1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKMYYLKMLLFNFLINVLVLPHYENYQNNHYNIRLIPNNTYRITIKSRLLAQTQIHNPHYHNDPELKEIIDKLNEDAIKKYQQTHDPYEQLQEVVEKNGTKYKGGNDAEPMSTLEKELLQTYEEVFGNESDMLKSGMNTNVDEKSSTCGCTDINGVKLAKTKGRDKYLKHLKHRCTRGICFCSVGSALLTMFGLAVAKKAAVDAILPVYVAAIKKCVSSSSLFHIFHGGSLTTALKATEACASVAGPDIVIPATGAAIGAFPPYGIAALVLLILAVLLIILYIWLYRRRKNSWKHECKKHLCK
Protein: Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Q9VTU4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit H
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit M
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit F-1
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit D-1
Sequence:
MYGGDEYATNSDYYDDYAHTGDPQLDMEYERNYYAARMPDNVKYFLINFCQAIKEGNLYDIQNMYENTFPQISDHHFDKTAWPEEQEVAAIVDNDKVFLILYKELYYRHIHARIPGGPKLEQRINSFFNYCDFFNLIISAQNPVMLELPDIWLWELVDEFVYQFQNFAQYRARLTEKSQDEIQQLCVNHSNEWSILCILNVLHSLVDISNIKKQLEAISQGVDPQTVAGDFGKLSFYKMLGYFSLVGLLRVHSLLGDYYQAIKVLEPIEIHKKSAYSHIPACQISTSYYVGFAYMMMRRYADAIRTFSDILLYIQRTKQLYSTRSYQNDQINKQAEQMYHLLAICLVLHPQCIDESIQQVLREKNYHDAMFKMQCGDLEVFKSFFVFACPRFVSPCPPAVDAPMDDYVKDPMEHQLQVFMDEVRQQKDLPTTRSYLKLYTTLPLTKLASFIDPNASEDDVSKLLIRLLCFKHKMRNLVWSKGPSGLEGTFKSGSELDFYIDDDMIHIADTKVSHRYGDFFVRKILKFNDLNRKLKNINI
Protein: Nuclear transcription factor Y subunit C-6 (OsNF-YC6) (Transcriptional activator HAP5D) (OsHAP5D) (Q9XE33)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Component of the NF-Y/HAP transcription factor complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:26542958}. Cytoplasm {ECO:0000269|PubMed:26542958}.
Interaction partners:
- Nuclear transcription factor Y subunit B-11
- Nuclear transcription factor Y subunit B-8
- Nuclear transcription factor Y subunit B-10
- Os09g0568200 protein
- Nuclear transcription factor Y subunit B-2
- Nuclear transcription factor Y subunit B-3
- HAP3 subunit of HAP complex
- HAP3 subunit of HAP complex
- HAP3 subunit of HAP complex
- Nuclear transcription factor Y subunit
Sequence:
MEPKSTTPPPPPPPPVLGAPVPYPPAGAYPPPVGPYAHAPPLYAPPPPAAAAASAAATAASQQAAAAQLQNFWAEQYREIEHTTDFKNHNLPLARIKKIMKADEDVRMIAAEAPVVFARACEMFILELTHRGWAHAEENKRRTLQKSDIAAAIARTEVFDFLVDIVPRDEAKDAEAAAAVAAGIPHPAAGLPATDPMAYYYVQPQ
Protein: uroporphyrinogen-III C-methyltransferase (EC 2.1.1.107) (P95417)
Organism: Pseudomonas aeruginosa
Interaction partners:
Sequence:
MNTTVIPPSLLDVDFPAGSVALVGAGPGDPGLLTLRAWALLQQAEVVVYDRLVARELIALLPESCQRIYVGKRCGHHSLPQEEINELLVRLARQQRRVVRLKGGDPFIFGRGAEELERLLEAGVDCQVVPGVTAASGCSTYAGIPLTHRDLAQSCTFVTGHLQNDGRLDLDWAGLARGKQTLVFYMGLGNLAEIAARLVEHGLASDTPAALVSQGTQAGQQVTRGALAELPALARRYQLKPPTLIVVGQVVALFAERAMAHPSYLGAGSPVSREAVACA
Protein: Probable ATP-binding component of ABC transporter (Q9HTI8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable glycine betaine-binding protein
- ABC-type glycine betaine transport system substrate-binding domain-containing protein
- Probable permease of ABC transporter
- Probable permease of ABC transporter
- ABC-type glycine betaine transport system substrate-binding domain-containing protein
- ABC-type glycine betaine transport system substrate-binding domain-containing protein
- Probable binding protein component of ABC transporter
- ABC-type glycine betaine transport system substrate-binding domain-containing protein
- Quaternary amine transport ATP-binding protein
- Lipoprotein-releasing ABC transporter permease subunit
Sequence:
MTAIRFDHVDVIFGTHTKEALKLLDQGLGRAEILKRTGQVLGVEDACLDVNRGEICVLMGLSGSGKSSLLRCINGLNKVSRGKLLIEHEGSQVDIANCSPATLKAMRTKRIAMVFQKFALMPWLTVAENVGFGLEMQGRPAAERKKLIDEKLELVGLSQWRDKRPDSLSGGMQQRVGLARALAMDGDILLMDEPFSALDPLIRQQLQDELLVLQRQLHKTIVFVSHDLDEALKIGTRIAIMKDGRIIQHGKPEEIVLSPADDYVRTFVAHTNPLNVLCGQSLMRGLDQCIRQNDEICFDQGRDCWIGLSEGDVLKGARQGSNVIDLQRWRQGDPVEKLRREPTLVDVSIRMRDALQIRYQTGHKLVLQEQDRVVGVLGDSELYHALLGKNLG
Protein: Magnesium transporter MRS2 homolog, mitochondrial (MRS2-like protein) (Q5NCE8)
Organism: Mus musculus (Mouse)
Function: Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9HD23}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HD23}.
Interaction partners:
- Insulin receptor-related protein
- Proteasomal ubiquitin receptor ADRM1
- Solute carrier family 41 member 3
- Solute carrier family 41 member 2
Sequence:
MECLRCLPGLLPRAAQPRRALWTAVARLSLAACGGRATPLRSRSPKASSTARAAGDVLRFRTSDASQATLASVAQVFAVTKFDKEGNVTSFERKKTELYHELALQARDLRFQHVMSITTRNNRIIMRMEYLKAVITPECLLILDYRNLNLEHWLFRELPSQLAGEGQLVTYPLPFEFRAIEALLQYWISTLRGRLSVLQPLILETLDALVDPKHSSVDRSKLHVLLQNGKSLSELETDIKIFKESILELLDEEEMLEELCLTKWSDPHVFEKSSTGIDHAEEMELLLENYYRLAEDLSNEARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDHRVFWLVTGIMFMGSGLIWRRLLSFLGRQLEAPVPPVMTSLPKKTLLANRRMDVKNSLRPEGLGASRTILASR
Protein: Activated in Blocked Unfolded protein response (P91419)
Organism: Caenorhabditis elegans
Interaction partners:
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Activated in Blocked Unfolded protein response
- Prion-like-
- Chitin-binding type-2 domain-containing protein
- Activated in Blocked Unfolded protein response
- Prion-like-
- Prion-like-
- Activated in Blocked Unfolded protein response
Sequence:
MNTKFSILFSLLAVSALAVAAEENVFLRARRQSSCGCAIPAAPQCNCQPAQTNTAQQSCSCAQAQQPSSCGCAQQYQQQQCAPTCQSSCEQSCVAQQQPIAQCQSSCSSTCQSACAQPVQLQQPAQQQCQQDCQAACPQQQQPQQQCQQQCQTTCQSDDQYSQQLIQQQTYAQPGQIPAYTGRSEYNTAPPQQQQASQCNTCQNSCLNTCQQQQQPVQQCQSSCDQSCQPQCATPSGSAYNQVNYQPQAQNNYQTNNNYQQPGAIPSYQGASQTAAPTYQPYRDTNVQVGGTISQCNTCQTQCNQECQVQQTPVNQCAPQCDAQCQPACSPAAPAAPVQTQQQIQLTINVPVARQSPQCQPQCEQSCNTQCIQQQQPISQCQPACQQSCSASCRK
Protein: RTX-I toxin determinant A (A3N292)
Organism: Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Subcellular location: Host cell membrane {ECO:0000256|ARBA:ARBA00004598}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004598}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- RTX toxin-activating lysine-acyltransferase
- Membrane fusion protein
- Toxin RTX-I translocation ATP-binding protein
- Transferrin-binding protein 1 Tbp1
- Leukotoxin translocation ATP-binding protein LktB
- Transferrin-binding protein A
- Predicted TonB dependent/Ligand-Gated channel
- Iron-regulated outer membrane protein B
Sequence:
MANSQLDRVKGLIDSLNQHTKSAAKSGAGALKNGLGQVKQAGQKLILYIPKDYQASTGSSLNDLVKAAEALGIEVHRSEKNGTALAKELFGTTEKLLGFSERGIALFAPQFDKLLNKNQKLSKSLGGSSEALGQRLNKTQTALSALQSFLGTAIAGMDLDSLLRRRRNGEDVSGSELAKAGVDLAAQLVDNIASATGTVDAFAEQLGKLGNALSNTRLSGLASKLNNLPDLSLAGPGFDAVSGILSVVSASFILSNKDADAGTKAAAGIEISTKILGNIGKAVSQYIIAQRVAAGLSTTAATGGLIGSVVALAISPLSFLNVADKFERAKQLEQYSERFKKFGYEGDSLLASFYRETGAIEAALTTINSVLSAASAGVGAAATGSLVGAPVAALVSAITGIISGILDASKQAIFERVATKLANKIDEWEKKHGKNYFENGYDARHSAFLEDTFELLSQYNKEYSVERVVAITQQRWDVNIGELAGITRKGADAKSGKAYVDFFEEGKLLEKDPDRFDKKVFDPLEGKIDLSSINKTTLLKFITPVFTAGEEIRERKQTGKYEYMTELFVKGKEKWVVTGVQSHNAIYDYTNLIQLAIDKKGEKRQVTIESHLGEKNDRIYLSSGSSIVYAGNGHDVAYYDKTDTGYLTFDGQSAQKAGEYIVTKELKADVKVLKEVVKTQDISVGKRSEKLEYRDYELSPFELGNGIRAKDELHSVEEIIGSNRKDKFFGSRFTDIFHGAKGDDEIYGNDGHDILYGDDGNDVIHGGDGNDHLVGGNGNDRLIGGKGNNFLNGGDGDDELQVFEGQYNVLLGGAGNDILYGSDGTNLFDGGVGNDKIYGGLGKDIYRYSKEYGRHIIIEKGGDDDTLLLSDLSFKDVGFIRIGDDLLVNKRIGGTLYYHEDYNGNALTIKDWFKEGKEGQNNKIEKIVDKDGAYVLSQYLTELTAPGRGINYFNGLEEKLYYGEGYNALPQLRKDIEQIISSTGALTGEHGQVLVGAGGPLAYSNSPNSIPNAFSNYLTQSA
Protein: 3-sulfolactaldehyde reductase (SLA reductase) (EC 1.1.1.373) (4-hydroxybutyrate dehydrogenase) (EC 1.1.1.61) (Gamma-hydroxybutyrate dehydrogenase) (GHBDH) (Succinic semialdehyde reductase) (SSA reductase) (P0A9V8)
Organism: Escherichia coli (strain K12)
Function: Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1-sulfonate (DHPS). Metabolite profiling studies showed that the enzyme also catalyzes in vitro the NADH-dependent reduction of succinic semialdehyde (SSA) to 4-hydroxybutyrate (GHB), and that it could be involved in the metabolism of SSA, and other potentially toxic intermediates that may accumulate under stress conditions. However, the enzyme exhibits a 42,000-fold greater catalytic efficiency for the reduction of SLA over SSA (Ref.6). Shows no detectable activity on the analogous glycolytic intermediate glyceraldehyde-3-phosphate (Ref.6).
Interaction partners:
- Sulfofructosephosphate aldolase
- Sulfoquinovose isomerase
- Sulfofructose kinase
- HTH-type transcriptional repressor CsqR
- Succinate-semialdehyde dehydrogenase [NADP
- Uncharacterized protein YihR
- Succinate semialdehyde dehydrogenase [NAD
- 4-aminobutyrate aminotransferase PuuE
- 4-aminobutyrate aminotransferase GabT
- Sulfoquinovosidase
Sequence:
MAAIAFIGLGQMGSPMASNLLQQGHQLRVFDVNAEAVRHLVDKGATPAANPAQAAKDAEFIITMLPNGDLVRNVLFGENGVCEGLSTDALVIDMSTIHPLQTDKLIADMQAKGFSMMDVPVGRTSANAITGTLLLLAGGTAEQVERATPILMAMGSELINAGGPGMGIRVKLINNYMSIALNALSAEAAVLCEALNLPFDVAVKVMSGTAAGKGHFTTSWPNKVLSGDLSPAFMIDLAHKDLGIALDVANQLHVPMPLGAASREVYSQARAAGRGRQDWSAILEQVRVSAGMTAKVKM
Protein: Homeobox-leucine zipper protein HDG10 (HD-ZIP protein HDG10) (Homeodomain GLABRA 2-like protein 10) (Homeodomain transcription factor HDG10) (Protein HOMEODOMAIN GLABROUS 10) (Q9S9Z0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- At1g70780
- F-box protein At1g60400
- Zinc finger, C3HC4 type
- Uncharacterized protein
- Methylsterol monooxygenase 1-2
- Methylsterol monooxygenase 1-1
- F-box protein At1g11810
- AT-hook motif nuclear-localized protein
- F13F21.27 protein
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7
Sequence:
MDSSHNDSSSDEEGIDSNNRRHHSNHQVQRLEAFFHECPHPDDSQRRQLGNELNLKHKQIKFWFQNRRTQARIHNEKADNIALRVENMKIRCVNEAMEKALETVLCPPCGGPHGKEEQLCNLQKLRTKNVILKTEYERLSSYLTKHGGYSIPSVDALPDLHGPSTYGSTSNNRPASYGSSSNHLPQQSSLLRRPFTRELINTTPLPKPVLLQHFQQLSQLEKNRMFEIAKNAVAEVMSLIQMEHSMWIKSTIDGRAIIDPGNYKRYFTKNSHLKSRSALQSHHESSMEVVVVQMDARNLVDMFLNTEKWARLFPTIVTEAKTIHVLDSMDHPRQTFSRVVYEQLHILSPLVLPREFIILRTCQQMKEDLWLIADVSCYLQNVEFESTAPICTKRPSGVLIQALPHGRSKVTWIEHVEVTDKVWPHQLYRDLLYGGFGYGARRWTATLQRMCERLSLYSMTDFPPTDYPGVVKTIEGRRSVMSLGERMLKNFAWIMKMSDKLDLPQQSGANNSGVRISVRTNTEAGQPPGLIVCAGSSLSLPLPPLQVYDFLRNLEVRHQWDVHCQGNPVTEAARFVTGPDQKNNVTFLQPSSVGEYKLMILQDGFIDALGGMVVYAPMNLNTAYSAISGQVDPSTIPILPSGFIISRDSHPSSSEVDGGSMTLLTLAFQIFVTGPSYYTDLNLKDSATTVNTLVSSAVQRIKAMLNCE
Protein: Amine oxidase [copper-containing] 3 (EC 1.4.3.21) (Amine oxidase copper-containing 3) (Copper amine oxidase) (Semicarbazide-sensitive amine oxidase) (SSAO) (VP97) (Vascular adhesion protein 1) (VAP-1) (O08590)
Organism: Rattus norvegicus (Rat)
Function: Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:8520629, ECO:0000269|PubMed:9083076}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q16853}.
Interaction partners:
- Amine oxidase [flavin-containing] A
- Amine oxidase [flavin-containing] B
- Aldehyde dehydrogenase, mitochondrial
- Aldehyde dehydrogenase
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Aldehyde dehydrogenase family 3 member A2
- 4-trimethylaminobutyraldehyde dehydrogenase
- Alpha-aminoadipic semialdehyde dehydrogenase
- Aldehyde dehydrogenase family 3 member B1
- Aldehyde dehydrogenase X, mitochondrial
Sequence:
MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQEMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYPHPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSWSLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQTPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFHSNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAWAEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSPDSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK
Protein: Probable G-protein coupled receptor Mth-like 1 (Protein methuselah-like 1) (Q9VXD9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable G-protein coupled receptor Mth-like 14
Sequence:
MDRSRSSRAASSNQFIRPCGLLTTVILLQTLVSMSLAIEEMSPPPAAPPRPSPPPTVKLNKCCHSGEYLNDGTCIAGSEALWLPMVYLVQQQRFFEPHGASPRFLKFLPNTRPTCRKDQTTEIFRSRGANVMLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQPINALEDPDYAANPLVQQEPPKASLRLSKCCGKWGSYNTQLQNCDLQPNHQAAVDGLLRLSPQLPEGSYQTSYGLPDCGQPGGYSIAGDWQDAKLDRNTAMLQLPHKNLSAGQYCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIGGTIEQANGQNLQKAVLTGGILVSIVFLSATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYLYSLYAWGGPLLITFVAACVDQLPETTLLRPGFGQLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWLVGGPHGVWFFTDLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRHDITNTTNGVQHSSSSQGLPSMAGGTEITQNTTTTTTTTNTTATHMPSNPAEDEVPEKAPIAPVAPIVKMETIC
Protein: Hyaluronidase-1 (BmHYA1) (HYA1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) (Venom spreading factor) (P86100)
Organism: Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Function: Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides. In venom, it may participate in the degradation of the extracellular matrix thus allowing a rapid spread of other venom components during the envenomation process.
Subcellular location: Secreted {ECO:0000269|PubMed:18611448}.
Interaction partners:
Sequence:
MTQNIQMTEMYQIILFASILAAISATSADFKVVWEVPSIMCSKKFKINVTDLLTSHKILVNQEETFNGDKIVIFYESQLGKYPHIESHGDINGGMLQVSDLANHLKIARDNISKFIPDPNFNGVGIIDWEAWRPLWKYNWGRMSEYRDRSKDLVKAKHPDWSPAQIEKVAIEEWENSAKEWMLKTLKLVEDMRPNAAWCYYLFPDCYNYGGKDQPSEYFCKNDIQEANDKLSWLWKQSTALCPSIYMQESHITKYNTSQRAWWIYARLRETIRLSHPNTLIYPYINYILPGTKKTVPSMDFKRVLGQIGSLGLDGAIIWGSSYHVNTEEMCKEMKTYVKDVIAPVASTVIQNVNRCSQQICKGRGNCVWPEEPYTSWKYLIDPKNPTFKHTNISCKCKGGYTGRYCQIAP
Protein: Sperm axonemal maintenance protein CFAP97D1 (CFAP97 domain-containing protein 1) (B2RV13)
Organism: Homo sapiens (Human)
Function: Required for male fertility through its role in axonemal doublet stabilization which is essential for sperm motility and fertilization.
Interaction partners:
Sequence:
MNNSLDYLAYPVIVSNHRQSTTFRKKLDFGHYVSHKNRIQIAKPTVDTKPPVAHTNHILKLSKLQGEQKKINKIEYENKQLCQKIANAHRGPAKVDCWNEYFSKSLNRETRNRELVRITMENQGILKRLVDRKPHYDRRASEIDWQNSRRYIRNTTRYLLSQNE
Protein: Thioredoxin domain-containing protein 3 (3'-5' exonuclease NME8) (EC 3.1.-.-) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2) (Sptrx-2) (Q715T0)
Organism: Mus musculus (Mouse)
Function: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12909633}.
Interaction partners:
- Dynein axonemal intermediate chain 1
- Dynein axonemal intermediate chain 2
- Dynein axonemal heavy chain 5
- Outer dynein arm-docking complex subunit 1
- Dynein axonemal intermediate chain 3
- Dynein axonemal heavy chain 1
- Dynein axonemal light chain 1
- Dynein, axonemal, heavy chain 9
- Dynein axonemal heavy chain 11
- Dynein axonemal heavy chain 8
Sequence:
MASKKREVQLQSVVNSQNLWDEMLLNKGLTVIDVYQAWCGPCKAVQSLFRKLKNELNEDEILHFVVAEADNIVTLQPFRDKCEPVFLFSLNGKIIAKIQGANAPLINRKVITLIDEERKIVAGEMDRPQYVEIPLVDAIDEEYGEVQYESAAEVYNMAIIKPDAVLMRKNIEVREKIAKEGFVIEIQENLILPEEVVREFYTHIADQPDFEEFVVSMTNGLSCVLIVSQEDSEVIQEETLPQTDTEEEPGVLEEPHVRFAPVMIKKKRDSLQEYMDRQHMSDYCDVEDDAVKVSKLIDILFPDFKTMKSTNVQTTLALLHPDICEEEKDDVLNVIHNEGFTILMQRQIVLSEEEARTVCKIHENEEYFDNLIGHMTSNHSYVLALRRENGVEYWKTLIGPKTIEEAYASHPQSLCVQFASGNFPTNQFYGSSSKAAAEKEIAHFFPPQSTLALIKPHVTHKERMEILKTIKEAGFELTLMKEMHLTPEHANKIYFKITGKDFYKNVLEVLSLGMSLVMVLTKWNAVAEWRRMVGPVDPEEAKLLSPESLRAKYGLDILRNAVHGASNFSEASEIISNVFTEGNPEN