wanglab/gogpt-training-data huggingface dataset:
Protein: Probable 2-carboxy-D-arabinitol-1-phosphatase (EC 3.1.3.63) (Q9FNJ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphoglycerate mutase-like protein lacking PGM activity, but having 2-carboxy-D-arabinitol 1-phosphate (CA1P) phosphatase activity. Prevents the accumulation of D-glycero-2,3-pentodiulose-1,5-bisphosphate (PDBP) a potent inhibitor of ribulose-1,5-bisphosphate carboxylase (RuBisCO). PDBP is produced during the oxidation of ribulose-1,5-bisphosphate, the substrate of RuBisCO.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:21365755}.
Interaction partners:
- Triosephosphate isomerase, chloroplastic
- Triosephosphate isomerase, cytosolic
- Phosphoglycerate kinase 1, chloroplastic
- Cytosolic enolase 3
- Bifunctional enolase 2/transcriptional activator
- Enolase 1, chloroplastic
- Phosphoglycerate kinase 2, chloroplastic
- Scarecrow-like protein 8
- Phosphoglycerate kinase 3, cytosolic
- ATP-dependent 6-phosphofructokinase 4, chloroplastic
Sequence:
MISLPLTTPILPSRCLLHKTRRQNSTRRRLLIRSSSSLQDQFTVETTKRVVLVRHGQSTWNEEGRIQGSSDFSVLTKKGESQAEISRQMLIDDSFDVCFTSPLKRSKKTAEIIWGSRESEMIFDYDLREIDLYSFQGLLKKEGKEKFGEAFKQWQEDPANFIIDGHYPVRELWSRARSCWPGILAHESKSVLVVAHNAVNQALLATAIGLGTEYFRSLLQSNCGVSVLDFIPRADGGSPHVCLNRLNQTPNSPLAGGSSGGRKASKQIILVCHGQGNNEDSAVINQAANNDQAMNMLGVIHSQKTAELLLDLRVSSIVCSPKTASIESSGVISRVQEAAGCLGVDNVPHYVKTKQMNELDVESVLRKSNKDNDVIASQLDEEAFSALWNRSEKAWESLLDELSDEKSNPGEIMVVVGPAMTHISLIAQCLNLTKEALGLFHLDAGSISVIDFPDGPSSKGVIRCTNYTAHLGRWSIPITKPA
Protein: Putative calpain-like cysteine peptidase (Small myristoylated protein 1) (Q5SDH5)
Organism: Leishmania major
Interaction partners:
Sequence:
MGCGASSENSSVTYVNGRPTFVGEEVTKGFEKDNGLLFRIVNKKKKQWAYYNDTTQYEMHVLVTFNEDCDIKALGKTKLEQQENGEWVASVVVYPCETEMFIEGRVNGFKSKMDALPLSEEYRQHQAEKDK
Protein: Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B] (P00749)
Organism: Homo sapiens (Human)
Function: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Subcellular location: Secreted {ECO:0000269|PubMed:24434139}.
Interaction partners:
- Plasminogen activator inhibitor 1
- Urokinase plasminogen activator surface receptor
- Vitronectin
- Plasminogen
- Plasminogen activator inhibitor 2
- Glia-derived nexin
- Cathepsin B
- Cation-independent mannose-6-phosphate receptor
- Matrix metalloproteinase-9
- Plasma serine protease inhibitor
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
Protein: Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] (Q96T60)
Organism: Homo sapiens (Human)
Function: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
Subcellular location: Nucleus {ECO:0000269|PubMed:10446193}. Chromosome {ECO:0000269|PubMed:28453785}. Note=Localizes to site of double-strand breaks. {ECO:0000269|PubMed:28453785}.
Interaction partners:
- DNA repair protein XRCC1
- DNA ligase 3
- DNA polymerase beta
- DNA repair protein XRCC4
- Transcription termination factor 2
- DNA repair nuclease/redox regulator APEX1
- Tyrosyl-DNA phosphodiesterase 1
- Endonuclease 8-like 1 lyase Neil1)
- Endonuclease 8-like 2 lyase Neil2)
- Aprataxin and PNK-like factor
Sequence:
MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEETRTPESQPDTPPGTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITTRSGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAEEFKAKVEAVVEKLGVPFQVLVATHAGLYRKPVTGMWDHLQEQANDGTPISIGDSIFVGDAAGRPANWAPGRKKKDFSCADRLFALNLGLPFATPEEFFLKWPAAGFELPAFDPRTVSRSGPLCLPESRALLSASPEVVVAVGFPGAGKSTFLKKHLVSAGYVHVNRDTLGSWQRCVTTCETALKQGKRVAIDNTNPDAASRARYVQCARAAGVPCRCFLFTATLEQARHNNRFREMTDSSHIPVSDMVMYGYRKQFEAPTLAEGFSAILEIPFRLWVEPRLGRLYCQFSEG
Protein: Zonula occludens 2 protein (P70625)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
Interaction partners:
Sequence:
RGKLQLVVLRDSKQTLINIPSLNDSDSEVEDISEIESNRSFSPEERRQQYSDQEYHSSTEKLKERPSSREETSGRMSRMGATPTPFKSTGDITAAGVTEANKEPRSQEESPVPQPRTASRVFLRPSPENEAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSGVKKNIRKSREDLAAAVSVSTKFPAYEKVLLREAGFKKPVVLFGPIADIAMERLTTELPDLFQTAKTEPKDAGSEKSSGVVRLNTVKQIIEQDKHALLDVTPKAVDLLHYTQWFPIVIFFTPDSRQGIKTIRQKLNPTSNKISRKLFDQANKSKKTCSHLLTATINVNSANDGWFGSLKDSIQQQQHEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASRDQLRDGSPPPAFKPEPPKVRNQNREDSFNYSKSNFSAMAGSEIPGGSTKGCPPPIAVKPAFGRSILKPSTPVPMPESEEVGESTEEQEEAPKSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPQHMSSRPPEPQKAPSRLYQDTRGSYGSDPEEEEEYRQQLAAHSKRGYYSQPSRYRDTEL
Protein: Probable apyrase 7 (AtAPY7) (EC 3.6.1.5) (ATP-diphosphatase) (ATP-diphosphohydrolase) (Adenosine diphosphatase) (ADPase) (NTPDase) (Nucleoside triphosphate diphosphohydrolase 7) (F4JSH1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates (By similarity). Involved in the regulation of pollen and anther development.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Protein HUA2-LIKE 2
- Putative pumilio homolog 10
- At5g27920
- Chromatin remodeling 34
- Probable xyloglucan galactosyltransferase GT11
- Far-red impaired responsive
- Calmodulin-binding protein 60 B
- ASI1-immunoprecipitated protein 2
- Thioredoxin family protein
- Precursor of CEP13
Sequence:
MVFGRITELFTAASSRLPAGSQSSVPYMPTGSSPDVGTSVSDSISIGNGGRKNCLRHSASLQDFSSYHGFDPEESILPREAISWGQNGSSFSKEKGSVPNGTNPSTRRKLIRAVMIVMCLFLFAFLVYIVSMYIYTNWSRGASRYYVVFDCGSTGTRAYVYQASINYKKDSSLPIVMKSLTEGISRKSRGRAYDRMETEPGFDKLVNNRTGLKTAIKPLIQWAEKQIPKNAHRTTSLFVYATAGVRRLRPADSSWILGNVWSILAKSPFTCRREWVKIISGTEEAYFGWTALNYQTSMLGALPKKATFGALDLGGSSLQVTFENEERTHNETNLNLRIGSVNHHLSAYSLAGYGLNDAFDRSVVHLLKKLPNVNKSDLIEGKLEMKHPCLNSGYNGQYICSQCASSVQGGKKGKSGVSIKLVGAPNWGECSALAKNAVNSSEWSNAKHGVDCDLQPCALPDGYPRPHGQFYAVSGFFVVYRFFNLSAEASLDDVLEKGREFCDKAWQVARTSVSPQPFIEQYCFRAPYIVSLLREGLYITDKQIIIGSGSITWTLGVALLESGKALSSTLGLKSYETLSMKINPIALISILILSLLLLLCALSRVSNCLPRFFRKSYLPLFRHNSTSASSVLNIPSPFRFQRWSPMSTGVKTPLSPTVRGSPRRPFSFGSSIQLMESSLYSSSSCVMHSCSSDSLGDIQYDSTGSFWSSPRRSQMRLQSRRSQSREDLSSSLADSHMLKM
Protein: D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (Q07648)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs (Probable). Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). May also deacylate mischarged D-leucyl-tRNA(Leu). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality (By similarity).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:10766779}.
Interaction partners:
- Chitin synthase 1
Sequence:
MKIVLQKVSQASVVVDSKVISSIKHGYMLLVGISIDDSMAEIDKLSKKVLSLRIFEDESRNLWKKNIKEANGEILSVSQFTLMAKTKKGTKPDFHLAQKGHIAKELYEEFLKLLRSDLGEEKVKDGEFGAMMSCSLTNEGPVTIILDSDQ
Protein: Formin-like protein 5 (AtFH5) (AtFORMIN-5) (Formin homology 2 domain-containing protein 5) (Q94B77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Might be involved in the organization and polarity of the actin cytoskeleton. Interacts with the barbed end of actin filaments and nucleates actin-filament polymerization in vitro. Seems to play a role in cytokinesis.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Profilin-4
- Profilin-5
- Profilin-3
- Profilin-2
- Profilin-1
- Fimbrin-5
- Maternally expressed PAB C-terminal protein
- Formin-like protein 12
- Homeodomain-like superfamily protein
- Agamous-like MADS-box protein AGL36
Sequence:
MVGMIRGGMGDQNWSRLVFWLILFSGLLVITLEENPEKDEIFLSQFMAPSTGQVNEHMEETSWAQRCWQDSDCVKEAVAEFNLCFPGSKDSRELFGLNHTNLKQTLLDCIQEKGKLNGHNPKYLELLSSMLDIPRRNLATKPGSSPSPSPSRPPKRSRGPPRPPTRPKSPPPRKSSFPPSRSPPPPPAKKNASKNSTSAPVSPAKKKEDHEKTIIIAVVVTAVSTFLLAALFFLCCSRVCGNGSGGRKNDERPLLSLSSSDYSVGSSINYGGSVKGDKQGHQSFNIYSNQGKMSSFDGSNSDTSDSLEERLSHEGLRNNSITNHGLPPLKPPPGRTASVLSGKSFSGKVEPLPPEPPKFLKVSSKKASAPPPPVPAPQMPSSAGPPRPPPPAPPPGSGGPKPPPPPGPKGPRPPPPMSLGPKAPRPPSGPADALDDDAPKTKLKPFFWDKVQANPEHSMVWNDIRSGSFQFNEEMIESLFGYAAADKNKNDKKGSSGQAALPQFVQILEPKKGQNLSILLRALNATTEEVCDALREGNELPVEFIQTLLKMAPTPEEELKLRLYCGEIAQLGSAERFLKAVVDIPFAFKRLEALLFMCTLHEEMAFVKESFQKLEVACKELRGSRLFLKLLEAVLKTGNRMNDGTFRGGAQAFKLDTLLKLADVKGTDGKTTLLHFVVQEIIRTEGVRAARTIRESQSFSSVKTEDLLVEETSEESEENYRNLGLEKVSGLSSELEHVKKSANIDADGLTGTVLKMGHALSKARDFVNSEMKSSGEESGFREALEDFIQNAEGSIMSILEEEKRIMALVKSTGDYFHGKAGKDEGLRLFVIVRDFLIILDKSCKEVREARGRPVRMARKQGSTASASSETPRQTPSLDPRQKLFPAITERRVDQSSSDSD
Protein: Bidirectional sugar transporter SWEET7 (AtSWEET7) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 7) (Q8LBF7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8L9J7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 2B
- F16N3.9 protein
Sequence:
MVFAHLNLLRKIVGIIGNFIALCLFLSPTPTFVRIVKKKSVEEYSPIPYLATLINCLVWVLYGLPTVHPDSTLVITINGTGILIEIVFLTIFFVYCGRQKQRLIISAVIAAETAFIAILAVLVLTLQHTTEKRTMSVGIVCCVFNVMMYASPLSVMKMVIKTKSVEFMPFWLSVAGFLNAGVWTIYALMPFDPFMAIPNGIGCLFGLAQLILYGAYYKSTKRIMAERENQPGYVGLSSAIARTGSEKTANTNQEPNNV
Protein: X-ray repair cross complementing 4 (F7EEB9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLFVIPLSAFLRSSEMERKVSRISLASEPNVTYFLQVSWEGTIGSGFVITLTDGHSAWTAKVSESEIAQEADDMAMEQEKYMDELRRALVPESGAAGAYKFIFSKDTQHFSLEKELKDVSFRLGSFNLDKVTNPTEVIRELICYCLDTIAEKQAKNEHLQKENERLLRDWTDVQGRFEKCVSDKEALEADLYQRFILVLNEKKTKIRSLLSEVQQLEKSTKPERETPSSDKIPEEDGLYDGSTDEESGAPVLGADTLDKDDSLFSSPDVTDIAPSRKRRHRMQTNLGTEPKMAPQELPLQEKERLGSSPPQTLKEEGTSAAKMSLETLRNSSPEDLFD
Protein: Zinc finger protein neuro-d4 (BRG1-associated factor 45B) (BAF45B) (D4, zinc and double PHD fingers family 1) (Q92782)
Organism: Homo sapiens (Human)
Function: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- Actin-like protein 6B
- AT-rich interactive domain-containing protein 1A
- Zinc finger protein DPF3
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- AT-rich interactive domain-containing protein 1B
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
- SWI/SNF complex subunit SMARCC2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Zinc finger protein ubi-d4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Sequence:
MATVIPGPLSLGEDFYREAIEHCRSYNARLCAERSLRLPFLDSQTGVAQNNCYIWMEKTHRGPGLAPGQIYTYPARCWRKKRRLNILEDPRLRPCEYKIDCEAPLKKEGGLPEGPVLEALLCAETGEKKIELKEEETIMDCQKQQLLEFPHDLEVEDLEDDIPRRKNRAKGKAYGIGGLRKRQDTASLEDRDKPYVCDICGKRYKNRPGLSYHYTHTHLAEEEGEENAERHALPFHRKNNHKQFYKELAWVPEAQRKHTAKKAPDGTVIPNGYCDFCLGGSKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECKSCSLCGTSENDDQLLFCDDCDRGYHMYCLSPPMAEPPEGSWSCHLCLRHLKEKASAYITLT
Protein: Toll-like receptor 7 (P58681)
Organism: Mus musculus (Mouse)
Function: Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (By similarity).
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18305481}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305481}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305481}. Lysosome {ECO:0000269|PubMed:18305481}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:18305481}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Interaction partners:
- Myeloid differentiation primary response protein MyD88
- Toll-like receptor 8
- Protein unc-93 homolog B1
- Toll-like receptor 9
- Toll-like receptor 4
- Interferon regulatory factor 7
- Interferon-induced helicase C domain-containing protein 1
- Interleukin-1 receptor-associated kinase 1
- Toll-like receptor 3
- Interleukin-1 receptor-associated kinase 4
Sequence:
MVFSMWTRKRQILIFLNMLLVSRVFGFRWFPKTLPCEVKVNIPEAHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMVVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLLDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQMFKETV
Protein: Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) (GABAAR subunit gamma-3) (P28473)
Organism: Rattus norvegicus (Rat)
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Cell membrane; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Huntingtin-associated protein 1
- Vesicle-fusing ATPase
- Inactive phospholipase C-like protein 1
- Trafficking kinesin-binding protein 2
- Gamma-aminobutyric acid receptor-associated protein
- Gamma-aminobutyric acid receptor subunit beta-1
- Gamma-aminobutyric acid receptor subunit beta-2
- Gamma-aminobutyric acid receptor-associated protein-like 1
- Gamma-aminobutyric acid receptor subunit beta-3
- Gamma-aminobutyric acid receptor subunit alpha-1
Sequence:
MAAKLLLLLCLFSGLHARSRRVEEDDSEDSPSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDAHACPLTFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTTLGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTIRKKKTSLLHPDSTRWIPDRISLQAPSNYSLLDMRPPPPVMITLNNSMYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRRGRIHIDVSELDSYSRVFFPTSFLLFNLVYWVGYLYL
Protein: Cyclin Dx (D3GDI9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSVSLWCEEDSGRDRTHQASVRAPWDPSASGQRVIQRLLQSEERYLPSSLYISLVQREPQRREELAKWTMEVCCECDCDESVFPLAVSLLDRYLSATLSLPVSPSCLAAACILLASKVTESDTVSADTLCAAAEYDFLSANLREMERVVLATLRWDVLAVTPQDFIPLFLRTLGELRDGDGHTGDFLTTMRRHGDTLVAMCVCDSRFLGTPPSLVAAAALNSALRGLRARSAGEMSLMTAALATLCQTDVALLQCCTELIDGALRERLRTGAQEQKDGDIEEEERASTPTDLREIDF
Protein: Chromatin modification-related protein MEAF6 (Esa1-associated factor 6) (Q9VRN3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Enok complex which has a histone H3 acetyltransferase activity. Might be involved in transcriptional activation of selected genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:27198229}.
Interaction partners:
- YEATS domain-containing protein 4
- Enhancer of polycomb-like protein
- NuA4 complex subunit EAF3 homolog
- Transcription-associated protein 1
- Bromodomain-containing protein homolog
- Inhibitor of growth protein
- MRG/MORF4L binding protein
- DNA methyltransferase 1-associated protein 1
- Inhibitor of growth protein 5
- Brahma associated protein 55kD
Sequence:
MSSPTSKNVSETNGNKPKKSAKTSSNTKGGSMDTRAELADLIKKKAETSEQLANLERQIYAFEGSYLEDTQLCGNIIRGWERYLTSNKATNSKADKRNRKFKEAERLFSKSSITSMAICNPERASESDSITNEDSSDNQISINQNTTTAHDGTTTIKSTPKDEKDSPSHRNEGSVVSGMVSGSTNSGGNKDLLGTPTSNTKSKLSTNSSATAKKSGHINKKIRHR
Protein: Nuclear RNA export factor 1 (E9PLA7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSDAQDGPRVRYNPYTTRPNRRGDTWHDRDRIHVTVRRDRAPPERGGAGTSQDGTSKNWFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAV
Protein: Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) (O43312)
Organism: Homo sapiens (Human)
Function: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Actin, alpha skeletal muscle
- Src substrate cortactin
- Hematopoietic lineage cell-specific protein
- Zinc finger protein GLI1
- Receptor-type tyrosine-protein phosphatase delta
- Actin nucleation-promoting factor WAS
- Suppressor of fused homolog
Sequence:
MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS
Protein: ETS translocation variant 5a isoform 1 (ETS translocation variant 5a isoform X1) (ETS variant transcription factor 5a) (B0S6S7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004019}.
Interaction partners:
- Novel protein similar to vertebrate ring finger and WD repeat domain 2
Sequence:
MDGFYDQQVPFMVPPNQKSLQVEEPYNRPVNDRKRKLVETELAQDTEELFQDLSQLQEIWIAEAQVPDDEQFVPDFQSESLMFHGPPLAKIKRELSPSKELSPCSQDRSPMPYGEKCLYSYSAYERKPSTGFKPLTPPSTPVSPCVPSNALATRPLHEQTPPPVSNTALGQRLLHGQPTMTKSTPNQTCVPHHSQSPPFVVPCPPLNRETHFSNEPRFQRQLSEPCLPFPPSDAQGRPSFMPQVACTSPRDGRPPYHRQMSEPLVPVPPQGFKQELLDPRYVEQGVPNMGPSQAAFHPMAIKQEPRDFCFDSEVPKCQSSFGRAASFYQNHENFSFDREQQLYFDDTCVVPERLEGKVKQEPSVYREGPPYQRRGSLQLWQFLVTLLDDPSNGHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVKVAGERYVYKFVCDPEALFSMAFPDNQRPNLKADPDGLPTVDDDTLPLAHYDDGSSYLVDGGEQCVSGMPFPDGYVY
Protein: Zinc finger and BTB domain-containing protein 39 (O15060)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGMRIKLQSTNHPNNLLKELNKCRLSETMCDVTIVVGSRSFPAHKAVLACAAGYFQNLFLNTGLDAARTYVVDFITPANFEKVLSFVYTSELFTDLINVGVIYEVAERLGMEDLLQACHSTFPDLESTARAKPLTSTSESHSGTLSCPSAEPAHPLGELRGGGDYLGADRNYVLPSDAGGSYKEEEKNVASDANHSLHLPQPPPPPPKTEDHDTPAPFTSIPSMMTQPLLGTVSTGIQTSTSSCQPYKVQSNGDFSKNSFLTPDNAVDITTGTNSCLSNSEHSKDPGFGQMDELQLEDLGDDDLQFEDPAEDIGTTEEVIELSDDSEDELAFGENDNRENKAMPCQVCKKVLEPNIQLIRQHARDHVDLLTGNCKVCETHFQDRNSRVTHVLSHIGIFLFSCDMCETKFFTQWQLTLHRRDGIFENNIIVHPNDPLPGKLGLFSGAASPELKCAACGKVLAKDFHVVRGHILDHLNLKGQACSVCDQRHLNLCSLMWHTLSHLGISVFSCSVCANSFVDWHLLEKHMAVHQSLEDALFHCRLCSQSFKSEAAYRYHVSQHKCNSGLDARPGFGLQHPALQKRKLPAEEFLGEELALQGQPGNSKYSCKVCGKRFAHTSEFNYHRRIHTGEKPYQCKVCHKFFRGRSTIKCHLKTHSGALMYRCTVCGHYSSTLNLMSKHVGVHKGSLPPDFTIEQTFMYIIHSKEADKNPDS
Protein: Serine/threonine-protein kinase SAPK9 (EC 2.7.11.1) (Osmotic stress/abscisic acid-activated protein kinase 9) (stress-activated protein kinase 9) (OsSAPK9) (Q75V57)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May play a role in signal transduction of hyperosmotic response (Probable). Can phosphorylate BZIP46 in vitro.
Subcellular location: Cytoplasm {ECO:0000269|Ref.2}. Nucleus {ECO:0000269|Ref.2}.
Interaction partners:
- Probable protein phosphatase 2C 6
- Probable protein phosphatase 2C 8
- protein-serine/threonine phosphatase
- Protein phosphatase 2C 50
- bZIP transcription factor TRAB1
- bZIP transcription factor ABI5 homolog
- Probable protein phosphatase 2C 30
- bZIP transcription factor 46
- bZIP transcription factor 23
- protein-serine/threonine phosphatase
Sequence:
MERAAAGPLGMEMPIMHDGDRYELVKEIGSGNFGVARLMRNRASGDLVAVKYIDRGEKIDENVQREIINHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICSAGRFSEDEARFFFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKIADVWSCGVTLYVMLVGAYPFEDPEDPKNFRKTIQKILGVQYSIPDYVHISPECRDLITRIFVGNPASRITMPEIKNHPWFMKNIPADLMDDGMVSNQYEEPDQPMQNMNEIMQILAEATIPAAGTSGINQFLTDSLDLDDDMEDMDSDLDLDIESSGEIVYAM