wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) (Q9H992)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:37632749}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 7
Sequence:
MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWRHSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSYSQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQPGFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSLSHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSRSHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILPGSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLLLEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEAVTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA
Protein: Two-pore potassium channel 2 (AtTPK2) (Calcium-activated outward-rectifying potassium channel 2) (AtKCO2) (Q9FL25)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable voltage-independent potassium-selective tonoplast ion channel.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:16984403, ECO:0000269|PubMed:17764516}; Multi-pass membrane protein {ECO:0000269|PubMed:16984403, ECO:0000269|PubMed:17764516}.
Interaction partners:
- K
- L-type lectin-domain containing receptor kinase IV.2
- Potassium channel KAT3
- K
- K
Sequence:
MANDGNGDNNDDPLRQYLMNPRINPPPPSLLTLPENNDVTIPMPITPLELKNRLIFGSFVRSRKESSLPIDALSQNPSTSSSATTSFSDSTDLLLPLTEPNKPVRKSKPTINFHRSKTAPAMAAINNISHPNDPKTDQQSDSKTIVNQAVALLVVYLSLGVLIYWLNRDSYNVKQTHPVVDALYFCIVTMCTIGYGDITPDSVVTKLFSIFFVLVGFGFMDILLSGMVTYVLDLQENYMLETARNESLNLNDRDKVRSYIIDVKKGRMRIRLKVGLALGVVVLCLGFGVLIMHFVEKIGWLDSFYFSVMSVTTVGYGDRAFNTLAGRLLAAMWLLVSTLAVARAILFLAESRVDKRNRERAKKVLGESMSISQFLDADIDCNGCVSKAEFVIYKLKKMDKITEKDINPIGFQFDKLDRTNSGRITLLDLLESSTKDLPTATSI
Protein: At5g16040 (Regulator of chromosome condensation (RCC1) family protein) (UVB-resistance protein-like) (Q9LFS0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASATSVIAWGSGEDGQLGLGTDEEKELASVVDALEPFNVRSVVGGSRNSLAICDDGKLFTWGWNQRGTLGHPPETKTESTPSLVKSLANVKIVQAAIGGWHCLAVDDQGRAYAWGGNEYGQCGEEPSKDETGRPVRRDIVIPKRCAQQLTVRQVAAGGTHSVVLTREGYVWTWGQPWPPGDIKQISVPVRVQGLENVRLIAVGAFHNLALKEDGTLWAWGNNEYGQLGTGDTQPRSYPIPVQGLDDLTLVDIAAGGWHSTALTNEGEVYGWGRGEHGRLGFGDNDKSSKMLPQKVNLLAGEDIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGYGRKVTTGQPLELPIHIPPPEGRFNHTDEEDDGKWIAKHVACGGRHTLAIVEWKYDQEETE
Protein: Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) (P0CY19)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Interaction partners:
- Thymidylate synthase
- CENP-T/Histone H4 histone fold domain-containing protein
- Thymidylate kinase
- Proliferating cell nuclear antigen
- Deoxycytidylate deaminase
- Nucleoside diphosphate kinase
- Inosine triphosphate pyrophosphatase
- Pho100p
- Replication factor C subunit 5
- Ribonucleoside-diphosphate reductase
Sequence:
MTSEDQSLKKQKLESTQSLKVYLRSPKGKVPTKGSALAAGYDLYSAEAATIPAHGQGLVSTDISIIVPIGTYGRVAPRSGLAVKHGISTGAGVIDADYRGEVKVVLFNHSEKDFEIKEGDRIAQLVLEQIVNADIKEISLEELDNTERGEGGFGSTGKN
Protein: Ecdysone-induced protein 63E, isoform D (EC 2.7.11.22) (Ecdysone-induced protein 63E, isoform E) (Serine/threonine protein kinase variant L63A1) (Serine/threonine protein kinase variant L63A3) (Q9XTK9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MATTTTTTTTTGATNAKDGVTMREKKGGALQKLKKRLSHSFGRLTISREDGDESTHHHHHHHHHRGGHGGHHNHGNKVPYNGYNSEEYLDRLEPNGNIPADKTNCRYGAQESAKNDNNKPQDWRSTDSTDHHDRVQRQLSVSSDSKLLDEDIREEMKYHSHVVMRPKKPPRPKSEVFLNKQETHPRRKRFSAFGGDSPFGKQEAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELPDETSIFTVEGVQLYTEPNRQNK
Protein: Protein arginine N-methyltransferase SFM1 (EC 2.1.1.-) (SPOUT family methyltransferase 1) (Q12314)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that monomethylates ribosomal protein S3 (RPS3) at 'Arg-146'.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Protein arginine N-methyltransferase 2
- Putative methyltransferase YGR283C
- Protein arginine N-methyltransferase 1
- Putative methyltransferase YMR310C
- 25S rRNA
- Protein-lysine N-methyltransferase EFM2
- Probable ATP-dependent permease
- MIOREX complex component 12
- 25S rRNA
- Regulator of rDNA transcription protein 14
Sequence:
MKYIIEHMEEGFSEWVILEYSQILREVGAENLILSSLPESTTEKDIPQRLLKLGLRWTTKDLKGINEDFKDLELLKDGRVCLLDPRATIDLQPEDATKFDYFVFGGILGDHPPRDRTKELKTAYPNLLISRRLGDKQMTTDTAIRTTQLIIKDRIAFEDIKFIDYPEFRFNKNEATEMPFRYVLDKEGKPILPEGMLDLIKKDSAQSLDDLLM
Protein: Cdc23 domain-containing protein (Q4GYI6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Anaphase-promoting complex subunit 2
- Cyclosome subunit 1, putative
- Cell division cycle protein 16, putative
- Anaphase-promoting complex subunit 11
- Rev7, putative
- Ubiquitin-conjugating enzyme E2, putative
- E2 ubiquitin-conjugating enzyme
- Uncharacterized protein
- Anaphase-promoting complex subunit 10
- Non-specific serine/threonine protein kinase
Sequence:
MHQQDPTAGNNSGRGFVTVAEALDRAMKQCMQRGLFDTSTWLAQLALDASDSVLRQTLRTNAPAVLSLQDPPLVGRAHRHHVVALGLMQKGEYLRCHHHLSNALRDYNSCFSAGLSASTPSSLASAGITASRTEEPSGSAGDADGEEGATGREHFSFRRGGGRSTPPPRRQQQHQQSPLSKKATVPQAPPPQLQFLCLYSLYMAGECVKTTSSNPRKTTNPHLRMLRGLLLSALERQQQQQQHQGPQSSPTHPSSSAIRGSSSLLSVSSRPSSRAGPRLTQTGSRPSPPVTPGAAAASVGVAAYGDPFLCWLHGVVLRDLGMKQESATYFLAAVCNHPLLWCVWEDLCTLVSRENQIEEIEAMVGSLEPRFMPEIFLASVKAALNVSPISFVLPTAAPGAGQRSASPHFGESTTSLQSATQEYGRRRTHSRRDADGSSNSCVSPRLVNSWEVLLEQFPNNLFLLSNLAGYYYNVKKDLEKAHSIYKQLHEASPYRLESMDDYSIVLFLRGDRIGLSSLAQQVYHVDPFRAESNYVVGNYYVLMGAHDRGVLHFRRAVAADPTFIAAWTLLGHAYLETKNSAAAVEAYRAAVDLDQRDYRGWYNLGQIYELLQFYHHALYYYWHTTTLRPTDPRMWSAVANCLDREGRTGEAMLCLEHAEACESPKSDFYPPLVRRLGQYYLSIRKVQRAVTYLEKLLASEAKKHEDVLMAVPHVVTYYLRQAKQLLDIPARSPSYNPVHYYGGNSLTSTVVMETGCNAGASVYDDDGCGAPLSFSATGTHRVESFGSGPGVKAGGSLADQWLTADAVGRRSIDVRWEQAGACLSITERHLENLAAALGFPTLQAAVDSTMNRPSDSSVSGGDAMLEEGRNRHAAQLAHHFRELKNLQYYLRDQQQQVDTSVRQGERA
Protein: Pyruvate kinase (EC 2.7.1.40) (H3BTN5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAED
Protein: Three-finger toxin MS3 (Short neurotoxin MS3) (P86097)
Organism: Micrurus surinamensis (Surinam coral snake)
Function: Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to and inhibits the endogenous nicotinic acetylcholine receptors (nAChR) in human rhabdomyosarcoma TE 671 cell line with an IC(50) of 346 mM. This neurotoxin is lethal to mice by intraperitoneal injection and to zebrafish by injection at the back of the dorsolateral region.
Subcellular location: Secreted {ECO:0000269|PubMed:18384102}.
Interaction partners:
Sequence:
LICYSQMYNEIIKTCENGETTCYSKTWRDHRGTRLEKGCGCPPVKYDMIVKCCKTDRCGN
Protein: Defensin-like peptide (P85215)
Organism: Galleria mellonella (Greater wax moth)
Function: Has antibacterial activity against the Gram-positive bacterium S.lutea (MIC=1.9 uM). Lacks antibacterial activity against the Gram-positive bacteria L.monocytogenes and M.luteus, and the Gram-negative bacteria E.coli D31, E.coli ATCC 25922, and S.typhimurium. Has antifungal activity against A.niger (MIC=2.9 uM), C.albicans (MIC=2.9 uM), C.fructus (MIC=2.9 uM), C.wickerhamii (MIC=2.9 uM), P.pastoris (MIC=2.9 uM), P.stiptis (MIC=2.9 uM), P.tannophilus (MIC=2.9 uM), T.harzianum (MIC=2.9 uM), and Z.marxianus (MIC=2.9 uM), but lacks antifungal activity against C.albidus, F.oxysporum, and S.cerevisiae.
Subcellular location: Secreted {ECO:0000255|PROSITE-ProRule:PRU00710, ECO:0000269|PubMed:17194500}.
Interaction partners:
Sequence:
DKLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFWNVNCWCEE
Protein: chitin synthase (EC 2.4.1.16) (E7F1A0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
- UDP-N-acetylglucosamine pyrophosphorylase 1.
- Glucosamine
- DNA polymerase eta
- Lipase maturation factor
- Lipase maturation factor
- Ribosomal protein S6 kinase
- Ribosomal protein S6 kinase-related b
Sequence:
MEELKQRGQKREGRHRDTWDPFQLNPIGAEKEKKQVCFRILQNLVAVLVGLAVLVSGVVSKGSLLVLTTLAGPKSLRDEVEQQFYGLLLMCVLVTPNLLMFLKALWKCVFKSYVAPNPRTLGIVCGIEALVALGTAMLVLIVMPNLDILTNLCIPGGICIFSAVLQIAFRLQTRRWMILYPICSLILVVSGYFLLGIDYYVREKTYIKHFSDRLENVDDYMTYVYVGIAIFASLLVSLNWWENPFQASTNIQEMLSELDTFRDTAYVFTSFIRIVVTLAVYFLYFFVIANNQFEWDAYTKASQATQEIALGLFFLQAFCSAACHWFGVVACKIHAMKFGFALPVSLIGPATLILGMILFVTQSAQFNPSPEIAAIIKGNITNDFWPFCYELKSLSDVNTTPVVMLEISYSICKTSLNNPYEMWPFSMLALEGVCMWLALVSCTYYIWKIKVQRIERTSLLFVRRLYESAFIDISMLLNTKMKVIRTANRESNNDAELENCVIYLCATMWHETYDEMLKILTSMFRLDRYRGDPKEEHKDCFDFECHIYVDDAFMIEKDSGTKFVNTYVEDLIHVVMEVYRVFTNKEPDEVSIIETPYGGRLVFVMPEGNMLYVHLKDKQLIRNKKRWSQIMYLYYLLGWKGYNVKNPQKITRQNNPCRASLVSLDSETYLLPGLDNDSKRRHISDDNTYIMALDGDTDFHPKALILLVDRLRMYDNVGAACGRIHPTGMGPMVWYQKFEYAVGHWLQKTAEHVFGSVLCSPGCFSLFRGSALMDDNVLKRYTTKATRASEYVQYDQGEDRWLCTLLLQQGWRVEYNAASDAYTNSPQEFKEFYNQRRRWGPSTLANTLDLLHSGKETVKRNTSISMLYILYQIFTVASSILGPASVTLMIAGAFQFVFGVSGTLSIIIAVIPPVFYMLICFLAKPNLQITIAAILSVIYAFLMTASFFAIIGDMVIQGTFITPTGLFLVSGAILYMVTAVLHPQECTLIIYGLMYFICIPSGYLLLTIYSLVNMHIVSWGTRESTKGKEQKKQVGVVCNRDCRMCCWDVKIQVTQETENLLLQQMQQAVNPTAAAAAKAEPEEPATLSAAPEHSSVEISRHVQEKNMENKKDQSKENLNKDNKERDSESERSSSSSSSEKKMDTFNDDTDYEDTDYDDDDDDEDYDYNTVEPKEVVPESAWVEPVKREFLKKLTYANLKRNLQEQIRYTLRNKNQEDLCEELVLILTDTLNDELKDKVGPEDVLTETQLEELQYALNEAARRIVKTNRIETGSQRVERRVKRGIERTLVAPQVEKLSEDEQDFWEKLLERYLKPIQDDKAHLEEVTRELKSLRNKAVFLYFIINVLWVVATFFLQAIGGDVLSIEIPKYYPNKTLAPEPLRVEPLSLMFLLSFAVLLVVQFLAMLYHRVYTLIHVVSYRSSEKNYKEKDEEDEEDALILGNIIPSSLVITGDDLLNGDSFIPS
Protein: Fibrinogen silencer binding protein (A0A8I6A4U3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRRSAAPSQVRGNSSKKARFVPPGRSTTGVSKEISMSPEAKLVQGAHQSQGDAGVCSSNPWLTEGSPVEMGDGARVDPLSPVQTWMRLPKLVPVHCR
Protein: DNA-directed RNA polymerase subunit Rpo13 (EC 2.7.7.6) (B8YB65)
Organism: Saccharolobus shibatae (strain ATCC 51178 / DSM 5389 / JCM 8931 / NBRC 15437 / B12) (Sulfolobus shibatae)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (Probable). A molten-globule protein, it binds dsDNA in the RNAP, in vitro binds dsDNA but not ssDNA (Probable). Its position in RNAP implies it functions in both transcription initiation and elongation (Probable).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22848102}.
Interaction partners:
Sequence:
MVSGMSTEEEKEGTNDEEVSEEREVEETSEEEFPKLSIQDIELLMKNTEIWDNLLNGKISVDEAKRLFEDNYKDYEKRDSRRKAKKAASKKVKKTKKKEKSVEG
Protein: Utrn protein (Q6P6L2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAKYGDLEARPDDGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPISDMFSDLKDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVDLVNIGGTDIVDGNPKLTLGLLWSIILHWQVKDVMKDIMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDRVVKMSPIERLEHAFSKAHTYLGIEKLLDPEDVAVHLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEEIHIQSAVLAEEGQSPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKEQFATHETFMMELTAHQSSVGSVLQAGNQLMTQGTLSEEEEFEIQEQMTLLNARWEALRVESMERQSRLHDALMELQKKQLQQLSSWLALTEERIQKMESLPLGDDLPSLQKLLQEHKSLQNDLEAEQVKVNSLTHMVVIVDENSGESATALLEDQLQKLGERWTAVCRWTEERWNRLQEISILWQELLEEQCLLEAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLSNPKASKKMNSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVHVREQGMVKKPKQELPPPPPPKKRQIHVDVEAKKKFDAISTELLNWILKSKTAIQNTEMKEYKKSQETSGMKKKKK
Protein: Phospholipase C, PlcB (Q9I7A4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Lipoprotein
- peptidylprolyl isomerase
- Non-hemolytic phospholipase C
- Hemolytic phospholipase C
Sequence:
MKTFARLAAGLCICAIASQANAWSQPTHKNIVKDALAFMNSSYATEEMRQAYRFYVSAAGSEAQAGEILGQAAFDVDDFKDTRLGGWWVGYEHAPLWGAASGIVNYTSYWHFLNLARDGDSHGNPHGGYDYRYHKVDGGIADVDWYAMVYLYNRELKREDFDTTEAHYRQGTRSDWQEHYGDFQTAAFQPIDNLATYWFEQFRAAPSLQTIGYALHATGDVAQPHHVWITSANGHSSWEGWVDDHYASEKLNDPAAVANLVGRYDPSKSIRDLLTQTGQVAYARPEPLYDTSYETRLRVAKELIPESIALTVTVLTKGANSFDAPTAL
Protein: NAC domain-containing protein 5 (ANAC005) (O81914)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein RESTRICTED TEV MOVEMENT 1
Sequence:
MANPVGFRFRPTDGEIVDIYLRPKNLESNTSHVDEVISTVDICSFDPWDLPSHSRMKTRDQVWYFFGRKENKYGKGDRQIRKTKSGFWKKTGVTMDIMRKTGDREKIGEKRVLVFKNHGGSKSDWAMHEYHATFSSPNQIMTYTLCKVKFKGERREFSVATGSGIKHTHSLIPPTNNSGVLSVETEGSLFHSQESQNPSQFSGFLDVDALDRDFCNILSDDFKGFFNDDDEQSKIVSMQDDRNNHTPQKPLTGVFSDHSTDGSDSDPISATTISIQTLSTCPSFGSSNPLYQITDLQESPNSIKLVSLAQEVSKTPGTGIDNDAQGTEIGEHKLGQETIKNKRAGFFHRMIQKFVKKIHLRT
Protein: CRE-MEC-1 protein (H2KZ68)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTRQSMNASDSLFRKHCHFLHETEPINHTVSRGCGGNSNRFMRRAHCRNRCVKQPNKPEVQELKHRRTVTSTTSTPFQTVNEESTVEPSATKRLPVTLPVKKLELVQSSFQSGHGNGLCQDCDPLYGTCLDGKCGCMKGFRSLGKVCIDLNECDNGAVCGPNARCVNEIGSFQCVCDAGFSTDGDCKIGQEACMDEFDVNLTEEDCNNGKQEIKYYYDADSVQCKQFFYGGCKTTSRNFFADLQTCDVICVSNQRDYLKSKGQSLSHHPVLEISSDLNNGNDLKSNHYKIDLFSSPSSPVTPNRPLSADDWPLKPITLKPALNLDFSQGKTKSTAEKHKEADDAEILVHQLTPEHNSCDLKFEPVLREECISADWAEKFFWNSEFKDCEPFWYDSSCDPRDRAGKNFFETFEDCKNKCDGVQSQYVVPITTVPDEQSKIEEVETSETPGIVDETTTTAAPEEESEENGFFFKVKPQNYLEDVLSSETEETQHYGFNPNEFLKQNSQNQKPTEITEILRILPAQTEHDEASELKKEDKIEHDILEHLKNKEPTEKVLSTPSTCDLEYDDALRNECTSADWTELYYWNAQFKECEAFWYDSSCGDQDFSKKNLFKNFDDCNNQCVKKIGEALKKMDPETTTTTSTTTTTTTAPTTTKMEEPKRSNYKQSDPLNLILNKALNPDESSELPEKFPPAHEQGFVNFAIKSEVTATTKFDRLKYMAEFRKKLLALPDNFSTTPKQSSPTSSPTTTRMRSPSTHKSTVSQATKTASSTPQSPSTTTSFDDFVEKEKKTVLETIKILDRPEDLCDEPLHPKLEEDCKNDQWEIQWFFNSDRGACKSFWYGGCEIESRNFFPDHANCRHSCAHKYATPASFSSKVYIPPGELSTPVPPRKDRLTTSLKLTYPHSEDLFPSEEHSTVVELDGNFQRTEKQERIRLFPTKTFRPRAPTPTASNIVNVSEGEKTETAPAFYSHIDRVVHDMKTGEHPGYTKPEEFVRRIESASNDYIKYDLQKPDVVTIIDKSPPTVPSRKERTERTEVTTKLPSTRSINDPCDDEYDPKWDEDCLGDTWVVRSYYDSKAEKCKAFWYGGCHTSSRNIWFDKETCRTSCAHKFPTDMPMYGGAQSSEVSAEILPSPQEENSSKETSSSSSSSSSSNTAHISPEHRFKVDLDQKFADVKREHEGREDLAYSQMVQHPVTVSADCLEVYNASLSKPCGDGKSWSNRYFYDKDTRSCRMFWSNGCFSSSKNNFDDLETCQWKCEGRHPQPAGKSCLDKFDERYLEDCRHGEFTNRFYFDHDRKKCVAFHWGGCQSKSQNFFADMTVCQDLCESPPRELTQACLQPFDTTYETSCSAEKPQQYYYFDMSSGICKMFWFGNCKGENQNIFSTLEACQWICERKRDERKPAICADKFDTKYTESCGDSQWTEKWYFDQSSGDCSSFWWDECTSSSQNIFPDEKSCTSNCKHPGFEISSKLATEESKFRCLEPVEIGSCQETYPAFYYDRASRTCRPFAYSGCGGNSNRFMTVSQCENLCFAFNSMNEAEVDCHLPMHIGYGKNEDSCLPQAGFRFYYDRNYGKCSQMWYLGCGGNANNFYSYEICQRTCSQSDVPRELERKTRASSEVCFEPPGDRGICGKNSSTNPLKRWTYGNQKCTSFTYSGCGGNRNRFATQDICENTCNGLMNSNDPRICSFSPDWGSCNQLRYVWFYNLTRGTCDQFLYGGCGGNPNRFDTFEICQKACEVTGTDPCMESLDRGSWCEAMSNRYYFNKRARQCKGFHYTGCGKSGNNFLTKEECQTKCEKRFPRAAPSKKKAKVKLPVGYSGAKPKDKTPMLRHINLNGNNQTYFKSEPQWMDYSSCYGYRYNVTGRDTILNVHYCAIRGSADCISESYRSTEGEEYCNILRPFLRGQNLYSFYFGLDSVNPMYRPKDGLSGRIQRKNETIAAVLVLKANQCHEIC
Protein: tRNA (uracil(54)-C(5))-methyltransferase (EC 2.1.1.35) (Q09833)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation (By similarity).
Interaction partners:
- Ribosome biogenesis protein erb1
- Pseudouridine-metabolizing bifunctional protein C1861.05
- Ribosome biogenesis protein brx1
- Ribosome production factor 2 homolog
- tRNA-dihydrouridine
- Glycerophosphocholine phosphodiesterase gde1
- tRNA
- rRNA-processing protein cgr1
- Mitochondrial ornithine transporter 1
- Probable U3 small nucleolar RNA-associated protein 13
Sequence:
MYPYCLKYLTNGLRSKQMINFLCIQNILSARTLKICRFRFLPTPSHPTHKMAQETRAISSISEAANKRARKLSKRRAKKPVEEGSSGHVLLLEIENLIEKPVLANVPFERFQEIEVKISYLSSSGDGIGLVCNDQYAVVVPFTLPGDIVKAKLHFLADTYALADFLEVISPSEDRDDTLIKCPYFAKCGGCQYQMLSYDKQLLQKKRVVEKAFQYYSKLDSSLLPAIKDTVGSPLQYNYRTKITPHFDVPKGGTKGPLIIGFQEKGRRRVMDIEECPIATKTINEEYPKIIEDVQSRANTFKRGATILMRDSATEDGKHCVITDHKMIVREQFGDLSFTFPAGAFFQNNNSILEKFTSYVREQLLNPFGRKEHQRPKYFVDAYCGSGLFSVACSKGFLSVIGVEISADSVRYAEENAKRNNVSNATFIVGQAEKIFSSIETPPNETAMVIDPPRKGCDQSFLNQLLEYSPYRIVYISCNVHTQARDVGFLLSQEKGRSYKIDEIRGFDLFPQSHHVESILTLTKVVS
Protein: Probable eukaryotic initiation factor 4A (eIF-4A) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A) (O62591)
Organism: Leishmania major
Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
Interaction partners:
- Putative eukaryotic translation initiation factor eIF-4E
- Eukaryotic translation initiation factor 3 subunit I
- Putative eukaryotic translation initiation factor 4 gamma
- Putative translation initiation factor
- Polyadenylate-binding protein
- Polyadenylate-binding protein
- Eukaryotic translation initiation factor 6
- Putative elongation initiation factor 2 alpha subunit
- Putative eukaryotic translation initiation factor 5
- Putative eukaryotic translation initiation factor
Sequence:
MAQNDKIAPQDQDSFLDDQPGVRPIPSFDDMPLHQNLLRGIYSYGFEKPSSIQQRAIAPFTRGGDIIAQAQSGTGKTGAFSIGLLQRLDFRHNLIQGLVLSPTRELALQTAEVISRIGEFLSNSSKFCETFVGGTRVQDDLRKLQAGVIVAVGTPGRVSDVIKRGALRTESLRVLVLDEADEMLSQGFADQIYEIFRFLPKDIQVALFSATMPEEVLELTKKFMRDPVRILVKRESLTLEGIKQFFIAVEEEHKLDTLMDLYETVSIAQSVIFANTRRKVDWIAEKLNQSNHTVSSMHAEMPKSDRERVMNTFRSGSSRVLVTTDLVARGIDVHHVNIVINFDLPTNKENYLHRIGRGGRYGRKGVAINFVTEKDVELLHEIEAHYHTQIDELPVDFAAYLGE
Protein: Vanabin-interacting protein 1 (A4F2K9)
Organism: Ascidia sydneiensis samea (Vanadium-rich ascidian)
Interaction partners:
Sequence:
MMKTGIVILSIYFLVQRIVGKCVKNRYNDFNGDLYISKNGEEMCSWDFVQPNTMLDYVLVLRVFPLCDTSSLLSSASVTMPDGQDIENEIDQGEDVFCGSYVKSNKSCAANPNIRKLCNKTASTSVDWPPRFSAKLHRYSMVATYFYYKCGEAFNNISTKEGERSDNTTPLNGNDQTPLRYPTTNGEGNNNGATQTLGLSAYTSTTSSTRVKPEPLTKTKWIAIVIAILFLFSCILNVYLFAKCRQIRRLSSLKSIPPSEPTQEVVXHENIYTQQETEAQESNTEQLYQTTRNEVLDSNAVYNHLERQ
Protein: Muellerian-inhibiting factor (Anti-Muellerian hormone) (AMH) (Muellerian-inhibiting substance) (MIS) (P03971)
Organism: Homo sapiens (Human)
Function: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function (By similarity). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
Subcellular location: Secreted {ECO:0000269|PubMed:2974034, ECO:0000269|PubMed:3754790}.
Interaction partners:
- Anti-Muellerian hormone type-2 receptor
- Activin receptor type-1
- Bone morphogenetic protein receptor type-1A
- Steroidogenic factor 1
- Chordin
- Transcription factor SOX-9
- Progonadoliberin-1
- Noggin
- Neuroblastoma suppressor of tumorigenicity 1
- Bone morphogenetic protein receptor type-1B
Sequence:
MRDLPLTSLALVLSALGALLGTEALRAEEPAVGTSGLIFREDLDWPPGSPQEPLCLVALGGDSNGSSSPLRVVGALSAYEQAFLGAVQRARWGPRDLATFGVCNTGDRQAALPSLRRLGAWLRDPGGQRLVVLHLEEVTWEPTPSLRFQEPPPGGAGPPELALLVLYPGPGPEVTVTRAGLPGAQSLCPSRDTRYLVLAVDRPAGAWRGSGLALTLQPRGEDSRLSTARLQALLFGDDHRCFTRMTPALLLLPRSEPAPLPAHGQLDTVPFPPPRPSAELEESPPSADPFLETLTRLVRALRVPPARASAPRLALDPDALAGFPQGLVNLSDPAALERLLDGEEPLLLLLRPTAATTGDPAPLHDPTSAPWATALARRVAAELQAAAAELRSLPGLPPATAPLLARLLALCPGGPGGLGDPLRALLLLKALQGLRVEWRGRDPRGPGRAQRSAGATAADGPCALRELSVDLRAERSVLIPETYQANNCQGVCGWPQSDRNPRYGNHVVLLLKMQVRGAALARPPCCVPTAYAGKLLISLSEERISAHHVPNMVATECGCR
Protein: DNA polymerase delta subunit 3 (Q9SYL7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA polymerase delta small subunit
- DNA polymerase delta catalytic subunit
- At1g09815
- DNA polymerase epsilon catalytic subunit B
- DNA polymerase alpha subunit B
- Probable DNA primase large subunit
- DNA polymerase epsilon catalytic subunit A
- DNA polymerase zeta catalytic subunit
- PIF1 helicase
- PIF1 helicase
Sequence:
MTHTETLNLLDEIESFVSDQLQVVSYKWLSRNFSLSSNTAKRLLKDFVEKHGKGLEVVYIVSGLLKNGPSDYHARLASSTELPEVEKEFNGKYSVHIYSVQASIPMDPAAIWNTEFVQAEELFRQPSATDNCLKGNRFCGVSNSCVKRNIEGATENVTAPRTESVRTTGQSKSSSNFQKSTVPSNQGKNFQHSSSNVGHQAKSESIAAPAKNQSAKSSLDKEKAFHVPANKKNGQGEKSVTGTGGLLKNMWGRVPVKTEDDSPTVDVKNHITNHSEPQKPSHDADKKGGSDDETRDANFMRAPKDNRKRKVIFDFSDDEYEDVISLASPSSPKVNSRPDVELSSEDSGPEKPDADVSPEIKSEEPEASKEDRQNTASVDASTTLSTEKIQAIGSEAEVNPSKRRTTAVPSSPKRKKVLKSRIDDRGREVTEVVWEETETNAKKKEDTNTSKKLDDGKTANAVNRAVAQKKSPAIGNTAATNAGGKAGSKKGGNVKDPKQGNIMSFFKKV
Protein: Complement component C5 (Q90XS7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
FIKNKLGVDEKLQCHTLTVDNSKRTKDDGIALFICNLHSEAESASFIFKTADERLPFGSQAEYTLEAKAYSSPNERYLYIDLPSDYSGLQVGQHVSIQIYFHARSYLRIETFSYQIISRGKIVKFASEKRLQGTGSQAISFTVTSDMVPSIRLLVYYILHGEKTPELVADSVWIDVKDKCVNALKTELSFRKKDYKPKDELIFEVKTGQDSLVALSAIDTAVYSLRAPLQDPVTRVLRHIEQSDQGCGGGGGKDNADVFRLTGLTFITNANAQASQSEDDTCTASVRPKRALSYDQQKEKAKQYGKDFFCCWQGLHQIPTLDTCAHRANRLKVKLPSDVKKCRAVFTECCDYSLQLLQTSSDHVLARVEMAILFDLMPTQIRKLTFPESWLWEVQPVRSGQITLNRNLPDSLTTWEIKAVGVFKKEGSSGICVADPIKVSVTQAVSVDVPLPYSMVRGEQIELRGSVYNQAEDNIKYCVTLTAGAGVCLFQGKPTKDDGIKTTNCDKTSLLESGSVGLVTFTLMALEVGSHTLTFTLHTDKSRFNDQIVKTIRVVPEGIRTEDLSGGKLDPQGLYGAASRKVELSNTIPSQLVPKTSVERLLTINGEILGEVLAILNNPDGLRQLVNLPSGSAEGEIMRVLPIYFVYHYLETTGRWDIMGLEEHNSPLELKRKIREGITSILSFKRPREFSYSMWKDKEASTWLTALVVKTLGQVDKYVKVDSDMLSNSIFWLINKAQNEDGSFR
Protein: Nuclear envelope-associated protein 1 (AtNEAP1) (Plant IF-like protein) (Q9M9L3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:27630107}; Single-pass membrane protein {ECO:0000255}. Nucleus, nucleoplasm {ECO:0000269|PubMed:27630107}. Note=Colocalized with bZIP18 in the nucleoplasm. {ECO:0000269|PubMed:27630107}.
Interaction partners:
- bZIP transcription factor 18
- Protein KAKU4
- Protein CROWDED NUCLEI 4
- Protein CROWDED NUCLEI 1
- SUN domain-containing protein 1
- SUN domain-containing protein 4
- Plant UBX domain-containing protein 4
- Nuclear pore complex protein NUP93A
- Plant UBX domain-containing protein 5
- SUN domain-containing protein 5
Sequence:
MSYSEKTTVDPLLRDLDEKKESFRRNVVSLATELKQVRGRLVSQEQSFLKETITRKEAEKRGKNMEMEICKLQKRLEERNCQLEASASAADKFIKELEEFRLKLDTTKQTAEASADSAQSTKIQCSMLKQQLDDKTRSLREQEDRMTQLGHQLDDLQRGLSLRECSEKQLREEVRRIEREVTEAIAKAGIGGMDSELQKLLEDVSPMKFERMNRLVEVKDEEITKLKDEIRLMSGQWKHKTKELESQLEKQRRTDQDLKKKVLKLEFCLQEARSQTRKLQRKGERRDMEIKEIRDLISEKQNLNNESWDKQKFWDNSGFKIVVSMSMLMLVVVSKR