wanglab/gogpt-training-data huggingface dataset:
Protein: Solute carrier family 13 member 1 (Renal sodium/sulfate cotransporter) (Na(+)/sulfate cotransporter) (hNaSi-1) (Q9BZW2)
Organism: Homo sapiens (Human)
Function: Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine. Can also mediate the transport of selenate and thiosulfate (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q07782}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sulfate transporter
- Chloride anion exchanger
- 26S proteasome non-ATPase regulatory subunit 2
- Sulfate anion transporter 1
Sequence:
MKFFSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINAEAEVEATQMTYFNGSTNHGLEIDESVNGHEINERKEKTKPVPGYNNDTGKISSKVELEKNSGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCRCLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEMFKCGKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPGFATDSTVALLIGLLFFLIPAKTLTKTTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWAPAMSNETMP
Protein: Proteasome subunit beta (A0A1U9X8D7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU004203}. Nucleus {ECO:0000256|RuleBase:RU004203}.
Interaction partners:
Sequence:
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
Protein: Protein lethal(2)denticleless (Protein DTL83) (Q24371)
Organism: Drosophila melanogaster (Fruit fly)
Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- DNA damage-binding protein 1
- Cullin-4A
- Double parked, isoform A
- Cell division control protein
- Chromosome transmission fidelity 4
- Proliferating cell nuclear antigen
- CDC45L
- Protein MCM10 homolog
- DNA primase large subunit
- Exonuclease 1
Sequence:
MNIYNKLRAREHGYGNERTYDFALRRLSVAKEDSWRGIAPANYCPDFNPEPPIFSAKFANCDGYRHILAIANEDGKITLQDTTQRNHQPEEQSLVGPQCHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAGSGIRGLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILIWDIRANLNMDLTSRVDNCIYSGHTGGPGTPVSQRKQRTRTPKMAGGTTSSSITGLAFQDNDTLISCGAGDGVIKVWDLRRNYTAYKKEPLPRHKLPYAGSSTFRGFTNLIVDASGTRLYANCMDNTIYCYNLASYSQRPLACYKGLLNSTFYIKSCLSPDGKYLLSGSSDERAYIWNLDHAEEPLVALAGHTVEVTCVAWGSSHDCPIVTCSDDARHKIWRIGPDLDGLSEAERAEKYRGTASYVREFGKKAFGPSSGNHKYNLRDLESTPRSLKRLMDQNERTPGSVEKTTTKRSFLEMLGVAGQETEATEQPQKRAKPLESRGRRLFGPSSQETACRHIQLQSINEEDASPSKRQKENSAAEDVSPLHKLLSTPSHSPLSENVNHVYTSPPTTSAAAAAVAADALNPPPISAAIYSPTSNLPNYVLDGEAPHLGIMSPKRKAKEKVDWLTNIRKQKLMSGRAHVTLSEKISEEQQADVLASPRLQSLRQSECSPRIHASPRRRISHTDGGGGTPAGSSSHSHSQSQPKTPTSSRRNSETTLLRFFSIQRSSSVPAEETTTTNAAPSSSDPHPPAVTAPAATPLSMRTPTTAVGSD
Protein: Transporter (G5EF43)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Vesicular GABA transporter
- Glutamate decarboxylase 1
- Gamma-aminobutyric acid type B receptor subunit 2
- Lysosome-associated membrane glycoprotein 5
Sequence:
MVEATSVAEREQWSSWADFIMSCIGYAIGLGNVWRFPYLCYQNGGGAFLIPYCISLVFCGAPLFILETSWGQLMSVGGLGMFKICPIFKGVGIAAAVMAFWLNIYYIVVLSWAATYLYNSFTMSDVPWKNCDHAWNTPNCRSEYVKIPCDSNRTIAEFFNVKVLTHDHIHEYKKQFFVGEKMNWTVCSAADLSVVSPVKEFWNHRVLGISSGLENPGGIRWDLALFLLLVWIICYLCIFKGVKWTGKVVYITASFPYMMLFCLLIRGLTLEGAGVGLEFYLKPDFSKLLESKVWVDAVTQVFFSYGLGLGALVALGSYNKFNNNVYKQALTVCFVNSGTSVFAGFVIFSFIGFMATQQEKSVAEVAQAGPGLLFLAYPSGILQLPYTQFWSCLFFLMVLFLGVDSQFCTMEGFFTAIIDEFPQIRRKKYGREIFVGVICVISYLIGLTTVTEGGFYVFQLFDFYAASGWALLWLLFFECIAISWSLGIDRWYEHMKSMIGYYPSAWWKFCWVFATPSVCFGVLLFGLIKYQPLRIDAYNYDYPVWGHIFGWFLSLSSMLCIPGYAIWIWFKTPGTVQEKIKLLCRPDIEIKGAMENAENLELVEDFQNAI
Protein: Histone H2B.7 (HTB11) (Q9LZT0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H4
- E3 ubiquitin-protein ligase BRE1-like 1
- E3 ubiquitin-protein ligase BRE1-like 2
- Histone H3.1
- Histone H3.3
- Histone H3-like centromeric protein CENH3
- Histone H3-like 5
- Histone H3-like 1
- Histone H3-like 3
- Histone H3-like 4
Sequence:
MAPKAEKKPAEKKPVEEKSKAEKAPAEKKPKAGKKLPKEAGAGGDKKKKMKKKSVETYKIYIFKVLKQVHPDIGISSKAMGIMNSFINDIFEKLASESSKLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSS
Protein: Photosystem II reaction center protein L (PSII-L) (P60129)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01317}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01317}.
Interaction partners:
- Photosystem II reaction center protein H
- Photosystem II CP47 reaction center protein
- Cytochrome b559 subunit beta
- Photosystem II protein D1
- Photosystem II reaction center protein M
- Photosystem II reaction center protein T
- Cytochrome b559 subunit alpha
- Photosystem II CP43 reaction center protein
- Expressed protein
- Photosystem II reaction center protein Z
Sequence:
MTQSNPNEQSVELNRTSLYWGLLLIFVLAVLFSNYFFN
Protein: Aquaporin-6 (AQP-6) (Q8C4A0)
Organism: Mus musculus (Mouse)
Function: Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9WTY0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Aquaporin-11
- Aquaporin-12
Sequence:
MEPGLCSRAYLLVGGLWTAISKALFAEFLATGLYVFFGVGSVLPWPVALPSVLQIAITFNLATATAVQISWKTSGAHANPAVTLAYLVGSHISLPRAMAYIAAQLAGATAGAALLYGVTPGGIRETLGVNVVHNSTSTGQAVAVELVLTLQLVLCVFASMDGRQTLASPAAMIGTSVALGHLIGIYFTGCSMNPARSFGPAVIVGKFAVHWIFWVGPLTGAVLASLIYNFILFPDTKTVAQRLAILVGTTKVEKVVDLEPQKKESQTNSEDTECLTSPCEEAVRSFSFTLGLC
Protein: Prokineticin-2 (PK2) (Protein Bv8 homolog) (Q9QXU7)
Organism: Mus musculus (Mouse)
Function: May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Prokineticin receptor 2
- Prokineticin receptor 1
- KiSS-1 receptor
- Progonadoliberin-1
- Tachykinin-3
- Gastrin-releasing peptide
- Neuromedin-S
Sequence:
MGDPRCAPLLLLLLLPLLFTPPAGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGQVGDSCHPLTRKSHVANGRQERRRAKRRKRKKEVPFWGRRMHHTCPCLPGLACLRTSFNRFICLARK
Protein: DNA-directed RNA polymerase (EC 2.7.7.6) (Plastid-encoded RNA polymerase subunit alpha) (Q2LIP2)
Organism: Oryza rhizomatis
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Interaction partners:
Sequence:
RVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGETEGTCITHAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRNASICVKGPRYITAQDIILPPSVEIVDTAQPIANLTEPTDFRIELRIKRDRGYHTEVRKNTQDGSYPIDAVSMPVRNVNYSIFSCGNGNAKYEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHTEEEGTRFQENQNRFTSPLLSFQKRLTNLKKNKKRIPLNCIFIDQLELPSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFRMQDGKQIWDTLEKHLPMDLPKNKF
Protein: Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) (P13637)
Organism: Homo sapiens (Human)
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Subcellular location: Cell membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit gamma
- Sodium/potassium-transporting ATPase subunit beta-3
- Sodium/potassium-transporting ATPase subunit beta-2
- Sodium/potassium-transporting ATPase subunit alpha-2
- Protein ATP1B4
- Sodium/potassium-transporting ATPase subunit alpha-1
- Sodium/potassium-transporting ATPase subunit alpha-4
- Phospholemman
- Mitogen-activated protein kinase 1
Sequence:
MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY
Protein: 60S ribosomal protein L3 (Q8IJC6)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- 60S ribosomal protein L18-2, putative
- 40S ribosomal protein S21
- 40S ribosomal protein S24
- 40S ribosomal protein S5, putative
- 60S ribosomal protein L29
- 40S ribosomal protein S28e, putative
- 40S ribosomal protein S11, putative
- Small ribosomal subunit protein eS12
- 60S ribosomal protein L32
- Small ribosomal subunit protein uS2
Sequence:
MSHRKFERPRHGSLGFLPRKRCKRLRGKIRSFPKDDKEKPPHFTAFMGYKAGMTHIVREVDKPGSKLHKKEIVEACTIIECAPMVVVGIVGYRETPKGLRILSTVWANHVSDEFRRRYYKNWYKSEKKAFTKSLNVPEATKNCLLKRIEKYCTVLRAICHTQPSKTPLRMKKAHIMEVQINGGSMKEKLEFVKEMLEKNLPVSTVFNPNEMIDVISVTKGHGTKGVVSRYGVKRLPRKTHRGLRKVACIGAWHPARVQFQIPRHGQKGYFHRTERNKKIYRIGLKTDKNSASTDADITEKKITPMGGFPHYGVVNEDFLLLKGCVAGTKKRPITLRKNIVPQVSRDALAQVSLKFIDTSSKIGHGRFQTSEEKVKYYGPLKKDLKA
Protein: RNA helicase (EC 3.6.4.13) (A0A2R8Y645)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASRRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYVLFCFCFFVLFCFVLLFLAELRSCCPGWSAMARSRLTTTSASRVQAILLPQPPRYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN
Protein: Phosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin) (Q6RFY2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus matrix {ECO:0000250}. Note=Localized to the nuclear matrix-intermediate filament scaffold. {ECO:0000250}.
Interaction partners:
- Small integral membrane protein 17
Sequence:
MDQTPPARSEPLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKQGLLEMMEQDSESKACSPKEGSQPAQSEPSAGEQETLTSEGVQPGSPSASGTDQASQDELLSSDAHPDDTAKMSSASSGEEADAGNLLPTTDEPSQEALSGSLDSPPRTLERSASQLPSPPLLPTPPPKASSKATKNVTGQAALFQGSSMKNNEPVLRGQLPTPTGSPHLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRECRGSPKKRMDVRLSRTSSMERGKERDEAWSFDGASENKWTAAKDSEENKENLILSSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVARAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP
Protein: Protein YhgF (P46837)
Organism: Escherichia coli (strain K12)
Interaction partners:
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit omega
Sequence:
MMNDSFCRIIAGEIQARPEQVDAAVRLLDEGNTVPFIARYRKEITGGLDDTQLRNLETRLSYLRELEERRQAILKSISEQGKLTDDLAKAINATLSKTELEDLYLPYKPKRRTRGQIAIEAGLEPLADLLWSDPSHTPEVAAAQYVYADKGVADTKAALDGARYILMERFAEDAALLAKVRDYLWKNAHLVSTVVSGKEEEGAKFRDYFDHHEPLSTVPSHRALAMFRGRNEGVLQLSLNADPQFDEPPKESYCEQIIMDHLGLRLNNAPADSWRKGVVSWTWRIKVLMHLETELMGTVRERAEDEAINVFARNLHDLLMAAPAGLRATMGLDPGLRTGVKVAVVDATGKLVATDTIYPHTGQAAKAAMTVAALCEKHNVELVAIGNGTASRETERFYLDVQKQFPKVTAQKVIVSEAGASVYSASELAAQEFPDLDVSLRGAVSIARRLQDPLAELVKIDPKSIGVGQYQHDVSQTQLARKLDAVVEDCVNAVGVDLNTASVPLLTRVAGLTRMMAQNIVAWRDENGQFQNRQQLLKVSRLGPKAFEQCAGFLRINHGDNPLDASTVHPEAYPVVERILAATQQALKDLMGNSSELRNLKASDFTDEKFGVPTVTDIIKELEKPGRDPRPEFKTAQFADGVETMNDLQPGMILEGAVTNVTNFGAFVDIGVHQDGLVHISSLSNKFVEDPHTVVKAGDIVKVKVLEVDLQRKRIALTMRLDEQPGETNARRGGGNERPQNNRPAAKPRGREAQPAGNSAMMDALAAAMGKKR
Protein: Vacuolar fusion protein MON1 homolog A (Q6PDG8)
Organism: Mus musculus (Mouse)
Function: Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (By similarity).
Interaction partners:
- Vacuolar fusion protein CCZ1 homolog
- Vacuolar fusion protein MON1 homolog B
- Ras-related protein Rab-7a
- Regulator of MON1-CCZ1 complex
- Vacuolar protein sorting-associated protein 41 homolog
- DNA ligase 4
- Vacuolar protein sorting-associated protein 11 homolog
- MAU2 chromatid cohesion factor homolog
Sequence:
MAADMQRKRSSECPEGTLAPSNGQSVERAESPTPGLTQGTEPGAGQEGAMFVHTRSYEDLTELEDREASGDSPKECVGSPPPLATDMRQISQDFSELSTQLTGVARDLQEEMLPGSSEDWPEPQGAAGRGAATEPSQEGSTEGEEEDATEAWRLHQKHVFVLSEAGKPVYSRYGSEEALSSTMGVMVALVSFLEADKNAIRSIHADGYKVVFVRRSPLVLVAVARTRQSAQELAQELLYIYYQILSLLTGAQLSHIFQQKQNYDLRRLLSGSERITDNLLQLMARDPSFLMGAARCLPLAAAVRDTVSASLQQARARSLVFSILLAHNQLVALVRRKDQFLHPIDLHLLFNLISSSSSFREGEAWTPVCLPKFNAAGFFHAHISYLEPDTDLCLLLISTDREDFFAVSDCRRRFQERLRKRGTHLALREALRTPYYSVAQVGIPDLRHFLYKSKSSGLFTSPEIEAPYSSEEEQERLLGLYQYLHSRAHNASRPLKTIYYTGPNENLLAWVTGAFELYMCYSPLGTKASAVSAIHKLMRWIRKEEDRLFILTPLTY
Protein: Imidazole glycerol phosphate synthase subunit HisH (EC 4.3.2.10) (IGP synthase glutaminase subunit) (EC 3.5.1.2) (IGP synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH) (P60595)
Organism: Escherichia coli (strain K12)
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
Subcellular location: Cytoplasm.
Interaction partners:
- Histidine biosynthesis bifunctional protein HisB
- Imidazole glycerol phosphate synthase subunit HisF
- 1-
- Histidine biosynthesis bifunctional protein HisIE
- ATP phosphoribosyltransferase
- Histidinol-phosphate aminotransferase
- Histidinol dehydrogenase
- Bifunctional purine biosynthesis protein PurH
- Adenylosuccinate lyase
- Adenine phosphoribosyltransferase
Sequence:
MNVVILDTGCANLNSVKSAIARHGYEPKVSRDPDVVLLADKLFLPGVGTAQAAMDQVRERELFDLIKACTQPVLGICLGMQLLGRRSEESNGVDLLGIIDEDVPKMTDFGLPLPHMGWNRVYPQAGNRLFQGIEDGAYFYFVHSYAMPVNPWTIAQCNYGEPFTAAVQKDNFYGVQFHPERSGAAGAKLLKNFLEM
Protein: Nephrocystin-1-like protein (Nephronophthisis homolog) (O17972)
Organism: Caenorhabditis elegans
Function: Plays a role in the extension of dendrites from phasmid ciliated sensory neurons. May be necessary for initial assembly of the cilium.
Interaction partners:
- NePHronoPhthisis
- Protein fantom
- Transmembrane protein 231
- MecKel-Gruber Syndrome
- Transmembrane protein 237 homolog
- TMEM
- B9 domain-containing protein 1
- B9 domain-containing protein 2
- CEntrosomal Protein
- Transmembrane protein 138
Sequence:
MSIFGSILSLQDAINRFPQFEYQINRLEKEQKDTEAASRASFRKHFVRQCQELHRQLDDHRNRIEKAKTDETYKKENALEQLDKLKQRLTALSPEKEQLSFSVSVDSQSEEEKPKMAAIGRRKSTMYNDDESEDSDNDSEIIETDVQLDDPLPSQPQPPQQQHQQPQPKPRQPITITKPLESKTLNERQELDEVISRLQNPSRGDSGEVMEPVVVRGNVFVAIDSWDAEAEGDLELIKGKKYRITQTRSDGWWTALDEYGQRGLVPKTYLQHVKEKPKNVPSKVSSRLGVRDSVIGISTTTDPSRREANRQASRVDDCLGKAYDNDTHLSLVCHMAPRLSTSNIGFHDLFWSHYKDQVYKRTVHISKIIRLVRFEKMPLIEHKALVRMALVDITNPKSTQIVSNVHTLVPRVKSSTWYFEKKESQTRSCIEFSDFVLRSNYRSPTVVLVVEASHLVKTQIGIEEKSLGHTYLRLIIDDKAVPSRTNVLYLDDEVMTKMKLPEASKRRVLVQVMDVPKDKVSYVDSLPDVIVFNALYLPFFHFYRRRAGTILIRDNRNPLSAEFISDPLLSVFPFVCDQHDIMDIMLKIWKTKKKVLAKKNEAEQTAEFFQTFLHTAFFIHGIRMISYDVKDDLTLSIRQQTMQRFVDALNKGLFKQFIADQQCKPINIIDYSLDLLGNHSID
Protein: Vesicle-fusing ATPase (EC 3.6.4.6) (A0A384MTI6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU367045}.
Interaction partners:
Sequence:
MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFD
Protein: Peroxisomal membrane protein PMP34 (34 kDa peroxisomal membrane protein) (Solute carrier family 25 member 17) (O70579)
Organism: Mus musculus (Mouse)
Function: Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O43808}. Peroxisome membrane {ECO:0000250|UniProtKB:O43808}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein PEX13
- Peroxisome assembly protein 12
- Peroxisomal membrane protein 11B
- Peroxisomal membrane protein PEX16
- ATP-binding cassette sub-family D member 3
- Peroxisomal membrane protein 2
- ATP-binding cassette sub-family D member 1
- Peroxisomal membrane protein 4
- ATP-binding cassette sub-family D member 2
Sequence:
MASVLSYESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHAVLLEIIKEEGLLAPYRGWFPVISSLCCSNFVYFYTFNSLKAVWVKGQRSSTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIIPTNYKGIIDAFHQIIRDEGILALWNGTFPSLLLVFNPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAIAKAIATTVTYPMQTVQSILRFGRHRLNPENRTLGSLRNVLSLLHQRVKRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLKSTHKH
Protein: Lymphocyte antigen 86 (A0A0A8P3N1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- CD180 molecule.
Sequence:
MKTYFNMLLFLILGLVQMDRAHSQDPQWPLHTICNSNKLTVTYRSCVISDPLQDVGVSFLPCPNKLTDPTTVRIAFILRQSITEFYSSIKLFLNGLHVWGVDEPLCLPQFPRFTFCGSRRGEMITFEMLIKSKVDLPLKGDFNLMVHGINQDGFQIACVNATLSFW
Protein: Transcription factor AP-2, isoform D (M9PIH9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- BTB/POZ domain-containing protein Tiwaz
- WW domain-containing oxidoreductase
- YEATS domain-containing protein 4
- Adaptor protein complex 2, mu subunit, isoform A
- Protein DEK
Sequence:
MHILHRTNDHQFEDQKFMMERLSGHGSLGLSSGSAAYTTHSGGHTGRSGPATGHSGHSSTHGSAATMHHQSLQSDFQPPYFPPPFHHSTQSPPQQQISGYLQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAGLRSTQDQLGIHRTHREAELQGHVTQLSHGFPYTDRRSDYGSAISAGAAHGTRLGHEHESLALHQALQNAVDDVQAPALDDNVAFMSDLPLIKSMKSGKEAGNIGSGSPSEVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSNGGGMVSSSLDKSKIDNEKK
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (A0A8I5ZUT5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MIINISHVWCCGEMKAIEDGNLEEMEEEVRLKKRKRRRNVDKDPVKEDVEKAKKRRGRPPAEKLSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEEESNEEEEEEDEEESEAEAKSVKVKIKLNKKEEKGRDTGKGKKRPNRGKAKPVVSDFDSDEEQDENEQSEASGTDDE
Protein: Sodium/sulfate cotransporter 2 (SAC1-like transporter 2) (CrSLT2) (D2K6F1)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Na(+)/sulfate cotransporter with a probable high-affinity for sulfate and a proteasome dependent turnover.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20498339}; Multi-pass membrane protein {ECO:0000269|PubMed:20498339}.
Interaction partners:
Sequence:
MGFGWQGSVSIAFTALAFVVMAADWVGPDVTFTVLLAFLTAFDGQIVTVAKAAAGYGNTGLLTVIFLYWVAEGITQTGGLELIMNFVLGRSRSVHWALARSMFPVMCLSAFLNNTPCVTFMIPILISWGRRCGVPIKKLLIPLSYASVLGGTCTSIGTSTNLVIVGLQDARYTKAKQLDQAKFQIFDIAPYGVPYALWGFVFILLTQAFLLPGNSSRYAKDLLIAVRVLPSSSVAKKKLKDSGLLQQSGFSVSGIYRDGKYLSKPDPNWVLEPNDILYAAGEFDVVEFVGEEFGLGLVNADAETSAERPFTTGEESVFTPTGGAPYQKLVQATIAPTSDLIGRTVREVSWQGRFGLIPVAIQRGNGREDGRLNDVVLAAGDVLILDTTPFYDEEREDSKNNFAGKVRAVKDGAAKEFVVGVKVKKSSEVVNKTVSAAGLRGIPGLFVLSVDRADGSSVEASDYLYKIQPDDTIWIATDIGAVGFLAKFPGLELVQQEQVDKTGTSILYRHLVQAAVSHKGPIVGKTVRDVRFRTLYNAAVVAVHREGARVPLKVQDIVLQGGDVLLISCHTNWADEHRHDKSFVLLQPVPDSSPPKRSRMVIGVLLATGMVLTQIVGGLKSREYIHLWPAAVLTSALMLLTGCMNADQARKAIYWDVYLTIAAAFGVSAALEGTGVAASFANGIISIGKNLHSDGAALIAIYIATAMLSELLTNNAAGAIMYPIAAIAGDALKISPKETSVAIMLGASAGFINPFSYQCNLMVYAAGNYSVREFAIIGAPFQIWLMIVAGFILCYMKEWHQVWIVSWICTAGIVLLPALYFLLPTKVQLRIDAFFDRVAQTLNPKLIIERRNSIRRQASRTGSDGTGSSDSPRALGVPKVITA