wanglab/gogpt-training-data huggingface dataset:
Protein: Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Farnesyl cysteine carboxyl methyltransferase) (FCMT) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT) (Q9WVM4)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O60725}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O60725}.
Interaction partners:
- CAAX prenyl protease 2
- CAAX prenyl protease
- GTPase NRas
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- GTPase HRas
Sequence:
MAGCAARVPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGVLLSFSQSSWNHFGWYVCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWIEFTLENIFWPELKQITWLSAAGLLMVIFGECLRKVAMFTAGSNFNHVVQSEKSDTHTLVTSGVYAWCRHPSYVGWFYWSIGTQVMLCNPICGVVYALTVWRFFRDRTEEEEISLIHFFGEEYLDYKKRVPTGLPFIKGVKVGL
Protein: Putative photopigment melanopsin (B8Y5Y5)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}.
Interaction partners:
Sequence:
EIPDHVLYTIGTCVLVIGSIGIIGNLLVLYAFYSNKKLGTPQNFFIMNLAVSDFLMSASQAPICFVNSLHREWILGDIGCDLYAFCGALFGITSMMTLLAISVDRYLVITKPLRSIQWTSKKRTMQIIAAVWLYSLGWSVAPLLGWSSYVPEGLMISCTWDYVTYSPANRSYTMILCCCVFFIPLLIILHCYLLMFLAIRSTGRDVQKLGSCSRKSFLSQSMKNEWKLAKIAFVVIIVYVLSWSPYTCVTLIAWAGRGNTLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYRKTIHNAVPCLRFLIRVSKNDLLRGSINESSFRTSLSSHQSLAGRTKNACVSSVSTGEANWSDVELDPVEPA
Protein: Lmo2180 protein (Q8Y589)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Interaction partners:
Sequence:
MKLYELTDNYLKVQEFLEENNTDAVKDTLDALTDSFHDKSENIVKIIKSLAADAEMAGIEAKRLLKRKQALENNVQNLKNYLQTEMERMEIRKINSTLFTIQIQKNPPSVEIVEEALLKPFFLLQEPKIDKKRIAEILKSGEEVKGARLVESESIRIR
Protein: Probable E3 ubiquitin-protein ligase WAVH2 (EC 2.3.2.27) (Protein WAV3 homolog 2) (RING-type E3 ubiquitin transferase WAVH2) (Q0WQX9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable E3 ubiquitin-protein ligase involved in the regulation of root growth. Acts as positive regulator of root gravitropism.
Interaction partners:
- Magnesium-chelatase subunit ChlI-2, chloroplastic
- Magnesium-chelatase subunit ChlI-1, chloroplastic
- Fas-binding factor-like protein
- E3 ubiquitin-protein ligase RMA
- At3g29270
- Magnesium-chelatase subunit ChlH, chloroplastic
- SBP family protein
- F-box protein At1g47056
- E3 ubiquitin-protein ligase CSU1
- Zinc finger A20 and AN1 domain-containing stress-associated protein 4
Sequence:
MVFGWRKAFCTSVSSNQDKPQQHSSLHTTDPPIPTPRFRSKFGFLSNPSTPRLRSRGGSGTGCRSSASTSVTIPSLPTSPKLHCRTTSNATPRTSNSSSPKFFSNPSSPKSSSSSSSQGGGGVSLLRATLLLNKSNSSRCAICLQRVNSNQSNSTAAIFTAECSHSFHLSCVNGLEDKRCPFCSAAWNHAPKSNYPAVNNNFGSDPIRRPEIREIKTGKSLRVYNDDEPLAYSPVSLAQINTIHESDENDDVEDDDDFPGFFRDSSITSDMVPSISGNLEVKLLPESAVVETGKKKETHVVIMKLKASPSPSSITDAIKARRPSIDLVTVLDLSNGGANLQTVKHAMRSVISLLREMDRLSIVVFSTGSKRLMPLRRMTAKGRRSARRMVDALGGMETTGGVGMSVNDALKKAVKVVEDRREKNPSTSIFVLSDGQDQPEAVLKAKLNATRIPFVVSTTRFSRPEIPVHSVYIASPGALLHAPLRDAFTERIASLLNVTLHNVKLNLSLVNGSHLTEISSVYSLTGRLENFGSGSVIQVGDLFAEEEREFLVELKVPTSSSGSHQVMSVQSSIVDQMTHQPMTCPKEKRFLIPRPQSVRYVSSSIERLRNLHSMCRAVADSRRLIEREDLSGAYQVLTTARSNASHSDDSLRSLEVELNELSRIKPRNSILNRTEDKPEQLTPTSAWRAAEKLAKVAIMRKHLNRVSDMHGLENARF
Protein: Karmoisin, isoform B (MIP12509p) (C8VV48)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform D
Sequence:
MAENEPLNDLQSQVNGRILPAANGHTASATNGLVHANGKDAMKPSAPVQNGNGNANGTHIEAPCCRDIHGKEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLIKCVKEEENGVSAPRAVVLANGDIEIAGNGHYRSAGTKSSAPLMGATNGINGSAPASPTIQSNGHVDNGTGSYPDSPWPSPTRISDSAACDHSSSSLHTNPGTLLPSCSHTALLSGRSGSSKSLPLGDEPKRRRYNYSIY
Protein: Autophagy-related 16, isoform C (IP15590p) (Q86BR6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSTEEHVWRAHVVRRLRERNRKECDNFKEIIEQNNRLIDHVAQLKADNLKISVENEQLRNAVSTGGTGSNVAIATLEKKLLSQQEELTELHKRKGENSQMIVDLNQKVEQQRIIISEKEHSLVEQQTNNNRLRAEVQLLHSSLEELKKLNNTMLDEHTALQLAFSSLEEKLRGVQDENRRLLERLMQYKSKDADKLNEENESIIRKRSAKLKRDLEDAVREPSSSSNAASSPGAASLQRNSSPAQFVGGLIGDEDFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSRASIDTLKATGYLGQANPTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRTEKQADDVLMPAKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLKIACGSADGAIYIWNVNGFLEATLKGHSTAVNAVSWSPNNNMLASVGKNKRCTIYSES
Protein: Spermatogenesis associated 13 (J3KQJ8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
TDFAFFLQPASRPPMPAHQVPPYKAVSARFRPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSYEDLCQASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRCPVAPPHQGLHPIHQRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK
Protein: Dynein axonemal intermediate chain 4 (WD repeat-containing protein 78) (Q6GPB9)
Organism: Xenopus laevis (African clawed frog)
Function: Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility.
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:E9PYY5}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:E9PYY5}. Dynein axonemal particle {ECO:0000269|PubMed:33263282}.
Interaction partners:
Sequence:
MRSKLGTHFKKASVISGSVTQSKVNQSTFSRSIIGTSSRKSLNLHAESKMGERNLSMVSKQSIKIFDDDGKDVSPQPLFQAEPGTVPQKQNKLFTPPDASGIGASDIFSSISLQHTAFNASFVGPFTRSTFGASTVSRSSKETESMTEDIEETGFKREIASLSEIQGKQHEMQPTEEDLDKIINIFLTDTETLWLLDMPPALTATDSENADLVRVRNQAYEDLCKDKVGNDKYIERMMQTFSGAPKNKEVQCDRIILEDTGVMASVWDLYDSYLSPESLPMKEAVDRAIETKNISSSRLSESRGTQSMNSLGRGDSFSSSIADIERLALTRIPDEVEPDSEEILKSEKFLQDLFFMERVVVENTFQSRLAAYRQLPVIADPDEDEDKISAMPSNIVSPSLNRLWSFACDVTKGHNVSSMSWNKKNSDLLAVGYGQFGFAEQKGGMACCWSLKNIMWPERIFHCECGVTAVDFSAVHPNLLAVGMYNGTVAIYNVQNNEDFPVLDSSDNPNKHTSPVWQLKWIEHDRGNLGDDKGEILVSVCADGRITRWHIRKGLDCNDLMKLKRTGSGKSKKSSNEKERKGEAFISRQAPGMCFDFLPKDSNIYLAGTEEGHIHKCSCSYNEQFLDTYRGHKGPVYKIVWSPFCPDVFLSCSADWCIHLWQQDVLLPILTFSNTTNAVYDIMWSPSSALMFGAVSENRVEIWDLGVSIIDPVIVNEANPGVKLTSILFAKNTDCVLIGDSD
Protein: Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (IGFBP-rP1) (MAC25 protein) (PGI2-stimulating factor) (Prostacyclin-stimulating factor) (Tumor-derived adhesion factor) (TAF) (Q16270)
Organism: Homo sapiens (Human)
Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
Subcellular location: Secreted.
Interaction partners:
- Insulin-like growth factor 1
- Insulin
- Insulin-like growth factor 2
- CCN family member 1
- CCN family member 2
- Metalloproteinase inhibitor 2
- Transcription factor Jun
- Insulin-like growth factor 1 receptor
- Protein c-Fos
- Charged multivesicular body protein 3
Sequence:
MERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL
Protein: Amino acid transporter, putative (Q584M0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Adenosine transporter 2, putative
Sequence:
MEVRNEPIGCCDAAVDPKSQEQREGTGFLARMSTFVATAIPPGGIAASAFNIASSTVGAGIVGLPSAANSSGLVMAIVYLIIITVMTIFSIYALGVAADKTKTHDFEGVAKVLFGAKGSYLVAATRAFHGFSGCVAYIISVGDILSAILKGTDAPDFLKEKWGNRLLTFIMWLCFMLPLAIPREVNSLRYVSTFAVSFIVYLVIVIVVHSCMNGLPENIKNVSVGRNDVAAIVLFNSGNKAIEGLGVFIFAYVSQITAYEVYVGMTNRSVGKFVMASTIAMAVCFTMYVLTAFFGYLDFGRDVTGSVLLMYDPVKEPAIMVGFIGLLVKLFASYALLGMACRNALYSIIGWDAEKVMFWKHCVAVVTLSVIMLLCGLFIPNINTVLGLAGSISGGLLGFIFPALLLLYAGGFTWQKVGPFHYIATYTVLITGVIAIVFGTGASIWGAINI
Protein: Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) (O95436)
Organism: Homo sapiens (Human)
Function: Involved in actively transporting phosphate into cells via Na(+) cotransport.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q9DBP0}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of enterocytes. {ECO:0000250|UniProtKB:Q9DBP0}.
Interaction partners:
- Na
- Sodium-dependent phosphate transport protein 2A
- Sodium-dependent phosphate transport protein 2C
- Sodium-dependent phosphate transport protein 1
- Proto-oncogene tyrosine-protein kinase ROS
- Coiled-coil domain-containing protein 6
- Golgi-associated PDZ and coiled-coil motif-containing protein
- Tropomyosin alpha-3 chain
- Leucine-rich repeats and immunoglobulin-like domains protein 3
- Sodium-dependent phosphate transporter 2
Sequence:
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL
Protein: Nuclear Hormone Receptor family (Q21805)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
- Glycosyltransferase family 92 protein R07B7.12
Sequence:
MDKDLADILPDIEIDQRSQESSSYSILTSTSIKCPRHNLPSKCEICGNPAIGYHYDIASCNGCKAFFRRTVITGRQVACKKWGTCLEEEIPINRRICPGCRFSKCVKVGMNPRAIRAEISSNGEILKNQLLKNREADKLVMLSPKTAEDDLSISISKLSLIENKIDDLFNSKWPSNYCDWRTVTEILKAHPILEMSKIPNLSFQPNQLFPDHAGFAHNASLAALEFTKMLDIFPKLSIDTVQKLVRHGLFMCGSMMTSRRSIQKFNSDTLRRTDGTISGKPAKSWNGVWVDHRKIVQRVLRAFLRIKLNDVEYLFLKVITILNPAVSDLFAQDQKIIERERNRFAQCLLTYCLREYAENNGPSRFASVLSIISSMELQQKEEKSFNILLRASFPDAIVLVSPLFDEIMSA
Protein: Glial lazarillo, isoform A (Glial lazarillo, isoform B) (Glial lazarillo, isoform C) (Glial lazarillo, isoform D) (Glial lazarillo, isoform E) (Glial lazarillo, isoform F) (A1Z991)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMSGQPLGSRVWLLSGVLLVTFAGTDAYGFGRCPNYPSMPKFNMSRVLGHWYEVERSFYLPEIASGCTTFQFEPYNKGEQSKFSNFKLAVAIKNINRITGNPNVNIGYATPENSRSSIMDFKFTTRFPDVIARLLPGSGKYQVLYTDYENFAILWSCGSIGSLGHSDQIWILGRDRDFEVDIRSKVYDVLKRLSLDPERLIISKNKQCPEAL
Protein: Magnetosome protein MamD (Magnetosome protein Mms7) (Q2W8R9)
Organism: Paramagnetospirillum magneticum (strain ATCC 700264 / AMB-1) (Magnetospirillum magneticum)
Function: Helps regulate magnetite crystal morphology, probably in a single growth axis. May help control oxido-reduction reactions surrounding the crystal lattice of the forming magnetite mineral (Probable). Probably binds Fe(2+), may play a role in nucleation of magnetite crystal formation (Probable). Expression in a deletion mutant restores growth of spherical (wild-type) magnetite crystals. Increased protein levels allow crystal growth in the minor axis but not increased numbers of crystals.
Subcellular location: Magnetosome membrane {ECO:0000269|PubMed:12496282, ECO:0000269|PubMed:16303747, ECO:0000269|PubMed:27417732}; Single-pass membrane protein {ECO:0000255}. Note=Tightly associated with magnetite crystals (PubMed:12496282). Upon overexpression small amounts of a larger (full-length) protein is seen in the cell inner membrane (PubMed:27417732). {ECO:0000269|PubMed:12496282, ECO:0000269|PubMed:27417732}.
Interaction partners:
- Magnetosome protein MamC
- Magnetosome protein MamF
- Magnetosome protein MamG
- Magnetite biomineralization protein Mms6
Sequence:
MQDLLLAKVESAMQASQVSALAGQTATVTKVSAATNLATITPTAAGQAPIIVKLDATRQVVELQALVGKTVMVGKTPAAIGGIGNWIALTPVTGAKAAAAATGAGQLVMMKVEGTAAAVNLPALAGKSFTIAQPPVAAGTKAAGMLYLNPVGGGDLIAINVQNAATQTGGLVGKTFVVAPSPVIGGTTGKFLVLKPLTAGAGKAVGGGAIAAKFIPAAVTGTGGAAAVGAGSASSLLTAGAGTVTPITAAGTGSAMLSAKGLGLGLGLGLGAWGPFLLGAAGLAGAAALYVWARRRHGTPDLSDDALLAAAGEE
Protein: Plexin b1b (Plexin-B1) (F1Q7U0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
- Uncharacterized protein
- Receptor protein-tyrosine kinase.
- Hepatocyte growth factor receptor
- Rho-related GTP-binding protein Rho6
- RAS-related
- Plexin D1.
- Sema domain, immunoglobulin domain
- Ras-like protein Rnd3b.
- Rho-related GTP-binding protein RhoE
- Semaphorin 7A
Sequence:
MPPGMVCVTSLFTILCCCAVTQSSASSRQHPTFLRNDTYFEHLALHPDPSVGRVYLGGRDRLYQLSSDLQLEAEEETGPVIDSRECLPPISEANCPQAQLTNNHNKLLLVDPYSQQLISCGSVHQGICQKRSLDAVGKVIFTAERPVDTQYVAANDPSVSTVGLVALTRGRGVQQPMLFVGRGYTNSQPPISTRNLVTEPVFSYEETSKLAVAGRLSEYDHHFVTSFTHRSYVYFMFYRRDLKSQSREYRTYVSRMCLDDTAYYSYVEVPLSCRSSRGKNYNLLQALHVGLPKFGKVWGRENAATSEQEVLLGVFSSHFASSSRPNEESAVCVFSLEEVDKRINSTRDLCYTEMGRADGQEAAYIEYEVKSNCANLPANTLDAYPCGSDHTPSPMASRVLVEAEPIFDSPSVRLTAVAVSVREEHTIAFLGDSQGNLHKVFLGPNGEVEEYAEISIQPNVPISRELRLDHQEKHLYILTSNMLEKRPVAECEKQLDCQSCLMAHDPYCGWCVLEGKCGLRSECSNGNQKDQWLWSFDIEQQCLSVTFLNPSNISREERRNISLAIPGLPRLDQGHNYSCVFLGKPSLAIVTETGVICSSPHINTLPSVPPGQDSFTVMLSVQFRDVVVTSQEFTFYDCTSVKQLAGSLPCHGCVQSHWGCNWCVKQHMCTHKTVCDEGLIIYNEHWKSLPTLPPATKASRAAFMTFPVTTHKSPETMAHTKPPTTAAVITESLTSTPSLTSPGPVKQTPSTKIFSSFKPSAVPTSASLAATLQPASTPSLLEEILSEKELLVTDIESVALSETETDVVTLTGLDAVVKTELPSVVEAAEEQRVSLPSSSSSSAVIEMSTETPPLIEPVTRDTFLTSTPRMFAERLNVTNETQTAVLPPSPEADGSETDTNDFLPISERVSPAMPSENRISTDHEAAQLAPQETEEVELLENDNSTFSAATVLSGDGESDSYPSVYLHSSDIDADYQYDSADLLADEGAFVNWGASACPCVEKIQGSSLLPVQTQRKISLLARNLQLYQDQELAYECVLVIEGQTVVVDADVAQNEANPLLFDITCLAHQYAYAEPVREYNAMVYVKRKDTFHIDSSDLYVTLYNCSVGHSDCSRCHTADQKYRCVWCGSTCVYKGSCSQHIQMTCPAPLIHLVEPLSGLVEGGITLTVSGSNLGQKAQDILQSVTVADVPCTVIPHLYEISTRIICTTTASGKEKSGHISVRVSGGGFGLSSQIFSYQDPHLFEVSPQRGPKAGGTTLTITGRNLLTGRVTDISVLLGNVPCSLISGVQENSIRCQTGASNRTGEHQVTVRYGNNERRLPGTGYFYTPDPNITDAMPSKSFISGGRVIKVSGHNLDVVQKPRMRVTVFPTDSISTWKKQRRRRKTRSTTDVEVLETDCTGNTHCSVKQFEEHCEVQTSSLLLCWTPGVDAEVLSGNMHVEFLLDNLRFDFNSVSQSPFTYKPNPILHPLNHRDPTKPYRYKPGSVISVEGENLDFAISKEEVVALIGEGVCTVKTLTHNHLYCEPPSQQPPLSLRHGRKREGAEAFPEFIVHMGNLNFSLGQVQYDSLSHSIFPLVAQIGVGAVASLVALIVLIIVFIYRRKSKQALRDYKKVQIQLENLETSVRDRCKKEFTDLMTEMMDVTSDLVGSRIPFLEYRMYAERIFFPGHRESPLRRDLDVQECRRATVEQGLIQLSNLLNSKLFLTKFIHTLESQRTFSPRDRGYVASLLTVALHSKLEYFTDILKTLLNDLVEQYIAKNPKLMLRRTETVVEKLLTNWISICLYGFLRNSAGESLYMLFRAIKHQVDKGPVDAVTGKAKYTLNDNRLLREDLEYRTLTVNVLMQGIGMNEAQPVAAKVLDCDTITQVKEKILDQVYKGTSFSHRPHTDSVDLEWRSGVAGHLILSDEDLTSVVQGNWKRLNTLQHYKVPDGATVALVPRHSKHIHHDTHDYIAGEKTPMLEDADEGGVRLWHLVKASEEPELPKHRRGSLKERERAKTIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAIKYFFDLLDDQAVRHGISDSETIHIWKTNSLPLRFWINIVKNPQFIFDVQVSDNVDAVLSVIAQTFMDSCTTTEHKLGRDSPINKLLYARDIPRYKQMVERYYADIKQTISASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDTTAQKMQLGYRLQQIAAAVENKVTDL
Protein: Ammonium transporter 2 member 1 (OsAMT2;1) (Q84KJ7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in ammonium transport.
Subcellular location: Cell membrane {ECO:0000305|PubMed:12610225}; Multi-pass membrane protein {ECO:0000305|PubMed:12610225}.
Interaction partners:
- Nitrogen regulatory protein P-II homolog
Sequence:
MAAAGAYSASLPAVPDWLNKGDNAWQLTASTLVGIQSMPGLVVLYGSIVKKKWAVNSAFMALYAYASSLLVWVLVGFRMAFGDQLLPFWGKAGVALTQSYLVGRATLPATAHGAIPRTEPFYPEATLVLFQFEFAAITLVLLAGSVLGRMNIKAWMAFTPLWLLLSYTVGAFSLWGGGFLYRWGVIDYSGGYVIHLSSGIAGFTAAYWVGPRLKSDRERFSPNNILLMIAGGGLLWMGWAGFNGGAPYAANIAASVAVLNTNVCAATSLLMWTCLDVIFFRKPSVIGAVQGMMTGLVCITPGAGLVQTWAAVVMGIFAGSVPWFTMMILHKKSALLMKVDDTLAVFHTHAVAGLLGGILTGLLATPELFSLESTVPGLRGAFYGGGIKQIGKQLGGAAFVIAWNLVVTTAILLGIGLFIPLRMPDEQLMIGDDAAHGEEAYALWGDGEKFDATRHDLSRGGGGGDRDGPAGERLSALGARGVTIQL
Protein: F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) (Q969U6)
Organism: Homo sapiens (Human)
Function: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21725316}.
Interaction partners:
- DNA damage-binding protein 1
- S-phase kinase-associated protein 1
- Protein transport protein Sec23B
- Cullin-4A
- E3 ubiquitin-protein ligase RBX1
- Cullin-1
- Cullin-4B
- DDB1- and CUL4-associated factor 13
- DDB1- and CUL4-associated factor 1
- Denticleless protein homolog
Sequence:
MDEGGTPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFYRYYQVARDVPRHPAAMSWYEEFQRLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVKIWSNDLTISLLHSADMRPYNWSYTQFSQFNKDDSLLLASGVFLGPHNSSSGEIAVISLDSFALLSRVRNKPYDVFGCWLTETSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTVRTVMVADCSRFDSPDLLLEAGDPATSPCRIFDLGSDNEEVVAGPAPAHAKEGLRHFLDRVLEGRAQPQLSERMLETKVAELLAQGHTKPPERSATGAKSKYLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDIHGHIIGMGLSPDNRYLYVNSRAWPNGAVVADPMQPPPIAEEIDLLVFDLKTMREVRRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTMRVLQAPRPRPRTFFSWLASQRR
Protein: G-protein coupled receptors family 1 profile domain-containing protein (A0A0B4J269)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSCSQDRALVSWDVKSLGGSVCQELLPQQPQEKGLCDQKASSTALQRLLQKEFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDEEESEAQGPK
Protein: 18.0 kDa class II heat shock protein (18.0 kDa heat shock protein) (OsHsp18.0) (Q5VRY1)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Chaperone protein ClpB1
- 18.1 kDa class I heat shock protein
- 16.9 kDa class I heat shock protein 3
- Os02g0297132 protein
- Os02g0297067 protein
- Os02g0537400 protein
- Os03g0321700 protein
Sequence:
MESAMFGLETPLMTALQHLLDIPDGEGGAAGKQGATGGPTRAYVRDARAMAATPADVKDLPGAYAFVVDMPGLKSSDIKVQVEEERLLVISGERRRGGGEEEKEESCKYLRMERRMGKFMRKFVLPDNADVDKISAVCQDGVLTVTVEKLPPPEPKKPKTIEVKVA
Protein: Regulator of chromosome condensation (Chromosome condensation protein 1) (Q8VE37)
Organism: Mus musculus (Mouse)
Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P18754}. Chromosome {ECO:0000250|UniProtKB:P18754}. Cytoplasm {ECO:0000250|UniProtKB:P18754}. Note=Predominantly nuclear in interphase cells. Binds to mitotic chromosomes. {ECO:0000250|UniProtKB:P18754}.
Interaction partners:
- GTP-binding nuclear protein Ran
- Ran GTPase-activating protein 1
- Importin subunit alpha-3
- Ran-specific GTPase-activating protein
- E3 SUMO-protein ligase RanBP2
- Importin subunit alpha-1
- Importin subunit alpha-4
- Ran-binding protein 3
- GTP-binding nuclear protein Ran, testis-specific isoform
- GTP-binding nuclear protein Ran
Sequence:
MPPKRIAKRRSPPEDAIPKSKKVKVSHRSHNTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDAPVVKVASGNDHLVMLTNDGDLYTLGCGEQGQLGRVPELFANRGGRQGLGRLLVPRCVLLKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKDQAQS