wanglab/gogpt-training-data huggingface dataset:
Protein: Integrin subunit alpha L (F1LP44)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Interaction partners:
- Intercellular adhesion molecule 1
- Integrin beta
- Intercellular adhesion molecule 2
- Integrin beta-1
- Junctional adhesion molecule A
- Integrin alpha-D
- Ras association domain-containing protein 5
- Vascular cell adhesion protein 1
- Proto-oncogene vav
- CD226 molecule
Sequence:
MSFRIPGPRLLLLGLQLFVNAWSYNLDTRHAQSFLTQAGRHFGYQVLQFGDGVVVGAPGEGNSTGSLYHCHPSSGSCQPVHLGSNHTSKYLGMTMVTDAAKGSLLACDPGLSRTCDQNPYLSGLCYLFSQSLGKPILQNRPAYQECMKGNVDLVFLFDGSQSLDKKDFEKIVDFMKDVMRKLSNTSYQFAAVQFSTECKTEFTFLDYIKLNKNPDVLLGNVTPMFLLTNTFRAINYVVTHVFKEESGARPDATKVLVIITDGEASDNGNIDAAQDITRYIIGIGKHFSTTQKQEKLHIFASKPVEEFVKILDTFEKLKDLFTDLQRKIYAIEGTSKQDLASFNMELSSSGISADLSKGHAVVGAVGAKDWAGGFLDLHEDLEGATFVGQEPLTSDERGGYLGYTVAWLTSRSSRPLLAAGAPRYQHVGQVLLFQAPEAGGHWNQTQKIEGTQIGSYFGGELCSVDLHQDGETDLLLIGAPLFYGEQRGGRVSVYQRRRSLFEMVSELQGDPGYPLGRFGAAISALTDINGDGLTDVAVGAPLEEQGAVYIFNGKPGGFSSQSSQRIPGTQVSPGVRWFGRSIHGVKDLGGDRLADVVVGAEGQVIVLSSRPVVDIVTELSFSPDEIPVHEVECSYSASQEQKEGVKLKVCFQIRPLTSQFQGRLLANLSYTLQLDGHRTRSRGLFPGGSRELGGNTSVTPDKSCMDFHFHFPICIQDLISPINVSLNFSLLEEEGSPRDQKGGRDMQPILRPSIHAVTKEIPFEKNCGEDKKCEADLALSPPARSGVLRLMSSASLAVEWTLRNLGEDAYWVRLDLDFPRGLSFRKVEMLQPHSQIPVSCEELTEESSLLTKTLKCNVSSPIFKAGKQMTLQVMFNTLLNSSWGDFVELNGTVHCENENSSLGKDNSATTRIPVLYPVNILTEDQENSTLYISFTPKGPKTQQVQHIYKVRIQPSAYDHNMPALEALVEVPQPHSEGPIAHTWTVHTDPLVTCHREDLKKPTREAEQPCLPGVQFRCPIVFRQETFIRVAGTVELSEKIKASSTLSLCSSLSVSFNSSKHFHLYGSKASKAQVLMKVDMIYEKEMLHLYVLSGIGGLLLLSLIFLALYKVGFFKRKLKEKMEADGGVPNGSPGEDADPLAVPGEETKDMGCLEPLRESDKD
Protein: Jun dimerization protein 2 (P97875)
Organism: Mus musculus (Mouse)
Function: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor Jun
- Transcription factor JunD
- Cyclic AMP-dependent transcription factor ATF-2
- CCAAT/enhancer-binding protein gamma
- Transcription factor JunB
Sequence:
MMPGQIPDPSVTAGSLPGLGPLTGLPSSALTTEELKYADIRNIGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKLERQQLILMLNRHRPTCIVRTDSVRTPESEGNPLLEQLDKK
Protein: Endonuclease NBR9 (EC 3.1.-.-) (Protein number nine) (Q08954)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Note=localizes to the proximity of the head region of the ribosomal 40S subunit (hr40S). {ECO:0000269|PubMed:34769086}.
Interaction partners:
- Uncharacterized protein ANR2
- Serine/threonine-protein kinase ENV7
- Palmitoyltransferase AKR1
- Translation machinery-associated protein 7
- RNA polymerase I-specific transcription initiation factor RRN11
Sequence:
MKGTGGVVVGTQNPVRDYNHSTDEEYQRLRRLADEAYKKRDQLSHESQTAYQQGDKKLAHELSEKSKAQLKTAEDFNMQAAEYVFVENNADSSSNEIDLHGLYVKEALFILQKRIKFAIDHNEPQLNVIVGKGLHSQNGIAKLKPSIEEFCAKHGIRNHLEKGNSGVLVLELQGVQMQMDGPAVNAPTNQYNAQPHPQYNNNGGQPQGQAQNYNNSGNDNKDSTLTSIFKIFCNCIQSLA
Protein: Transcriptional repressor GATA binding 1 (E5RFF3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSENTDQSDAAELNHKEEHSLHVQDPSSSTAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQKMSPKATEETGQAQSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSSTELEQHFLQTHPNKIKASLPSSEVAKPSEKNSNKSIPALQSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQDITTANGEEDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNVTWRGADILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIYGLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRGSNEEQVNGSPLERRSEDHLTESHQREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQTLDIHKRMQPLHIQIKSPQESTGDPGNSSSVSEGKGSSERGSPIEKYMRPAKHPNYSPPGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQNYVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPNVKNEGPLNVVKTEKVDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTTHIQRGLHRNNAQVEKNGKPKE
Protein: BLOC-2 complex member HPS3 (Hermansky-Pudlak syndrome 3 protein) (Q969F9)
Organism: Homo sapiens (Human)
Function: Involved in early stages of melanosome biogenesis and maturation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q91VB4}. Cytoplasm, cytosol {ECO:0000269|PubMed:15030569}.
Interaction partners:
- BLOC-2 complex member HPS6
- BLOC-2 complex member HPS5
- BLOC-3 complex member HPS4
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Dysbindin
- AP-3 complex subunit beta-1
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- BLOC-3 complex member HPS1
- SNARE-associated protein Snapin
Sequence:
MVQLYNLHPFGSQQVVPCKLEPDRFCGGGRDALFVAAGCKVEAFAVAGQELCQPRCAFSTLGRVLRLAYSEAGDYLVAIEEKNKATFLRAYVNWRNKRTENSRVCIRMIGHNVEGPFSKAFRDQMYIIEMPLSEAPLCISCCPVKGDLLVGCTNKLVLFSLKYQIINEEFSLLDFERSLIIHIDNITPVEVSFCVGYVAVMSDLEVLIVKLESGPKNGERVHHHPHKTNNRIRRTEEGISNEISQLESDDFVICQKPLELLGEKSEQSGLSVTLESTGLADEKRKYSHFQHLLYRRFAPDISSYVLSDDIKLHSLQLLPIYQTGSLTSDGKNLSQEKELLSLFCFFSLPHVGYLYMVVKSVELMSVYQYPEKSQQAVLTPQFLHVITSNNLQCFTVRCSAAAAREEDPYMDTTLKACPPVSMDVCALRIQLFIGLKAICHFKNHIILLTKAEPEAIPERRQSPKRLLSRKDTSVKIKIPPVAEAGWNLYIVNTISPVQLYKEMVDYSNTYKTVKTQSCIHLLSEAHLLVRAALMDASQLEPGEKAELLEAFKESCGHLGDCYSRLDSQHSHLTLPYYKMSGLSMAEVLARTDWTVEDGLQKYERGLIFYINHSLYENLDEELNEELAAKVVQMFYVAEPKQVPHILCSPSMKNINPLTAMSYLRKLDTSGFSSILVTLTKAAVALKMGDLDMHRNEMKSHSEMKLVCGFILEPRLLIQQRKGQIVPTELALHLKETQPGLLVASVLGLQKNNKIGIEEADSFFKVLCAKDEDTIPQLLVDFWEAQLVACLPDVVLQELFFKLTSQYIWRLSKRQPPDTTPLRTSEDLINACSHYGLIYPWVHVVISSDSLADKNYTEDLSKLQSLICGPSFDIASIIPFLEPLSEDTIAGLSVHVLCRTRLKEYEQCIDILLERCPEAVIPYANHELKEENRTLWWKKLLPELCQRIKCGGEKYQLYLSSLKETLSIVAVELELKDFMNVLPEDGTATFFLPYLLYCSRKKPLT
Protein: Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 1) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C) (O88445)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9UQB9}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9UQB9}. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis (By similarity). {ECO:0000250|UniProtKB:Q9UQB9}.
Interaction partners:
- Inner centromere protein
- Borealin
- Baculoviral IAP repeat-containing protein 5
- Histone H3-like centromeric protein A
- Cyclin-dependent kinase 1
- Cyclin-A2
- Kinetochore protein NDC80 homolog
- Kinesin-like protein KIF11
- Histone H3.1
- Histone H3.3
Sequence:
MEPSTSTRKHFTINDFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALTYCHEKKVIHRDIKPENLLLGLNGEVKISDFGWSVHTPSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLVGKPPFESSTSSETYRRIRQVDFKFPSSVPAGAQDLISKLLRYHPSERLSLAQVLKHPWVREHSRRVLPC
Protein: Cell cycle checkpoint protein RAD17 (Q6NXW6)
Organism: Mus musculus (Mouse)
Function: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination (By similarity). Essential for embryonic development. May be involved in homologous recombination.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O75943}. Chromosome {ECO:0000250|UniProtKB:O75943}. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage. Localizes to DNA double-strand breaks (DSBs). {ECO:0000250|UniProtKB:O75943}.
Interaction partners:
- Replication factor C subunit 2
- Cell cycle checkpoint control protein RAD9A
- Replication factor C subunit 4
- Replication factor C subunit 3
- Replication factor C subunit 5
- Checkpoint protein HUS1
- Cell cycle checkpoint protein RAD1
- Serine-protein kinase ATM
- DNA topoisomerase 2-binding protein 1
- Serine/threonine-protein kinase ATR
Sequence:
MSETFLRPKVSSTKVTDWVAPAFDDFEANTAITTITASSLTFSNSSHRRKYLPSTLESNRLSARKRGRLSLEQTHGLETSRERLSDNEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLEVKPKQGGSVLLITGPPGCGKTTTIKILSKELGIQVQEWVNPILPDFQKDDYKELLSLESNFSVVPYQSQIAVFNDFLLRATKYSKLQMLGDDLTTDKKIILVEELPNQFYRDPNALHEILRKHVQIGRCPLVFIVSDSVSGDNNQRLLFPRNIQEECSVSNISFNPVAPTIMMKFLNRIVTIEASKNGEKIIVPNKTSLELLCQGCSGDIRSAINSLQFSSSKGENSSWSKKKRMSLKSDAAISKSKQKKKHNSTLENQEIQAIGGKDVSLFLFRALGKILYCKRAPLTELDSPRLPAHLSEHDRDTLLVQPEEIVEMSHMPGDFFNLYLHQNYIDFFAEVDDLVPASEFLSFADILGGDWNTRSLLREYSTSVATRGVMHSNKARGFAHCQGGSSFRPLHKPQWFLIQKKYRENCLAAKALFVDFCLPALCLQTQLLPYLALLTIPMRNKAQISFIQDVGRLPLKRSFGRLKMEALTDRELGLIDPDSGDESPHSGGQPAQEAPGEPAQAAQNADPETWSLPLSQNSGSDLPASQPQPFSSKVDMEEEEEEEEDIIIEDYDSEET
Protein: Dystroglycan 1 (C9JQL4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MRMSVGLSLLLPLSGRTFLLLLSVVMAQSHWPSEPSEAVRDWENQLEASMHSVLSDLHEAVPTVVGIPDGTAVVGRSFRVTIPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTL
Protein: ES1 protein, mitochondrial (Q90257)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in promoting mitochondrial enlargement in cone photoreceptor cells in a fusion-independent and ATP-dependent manner.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:26926452}. Note=Colocalized with tom20 in cone mitochondria. Uniformly distributed throughout all mitochondria in cone ellipsoids including mega-mitochondria. {ECO:0000269|PubMed:26926452}.
Interaction partners:
- Isochorismatase domain-containing protein 1
- Isochorismatase domain-containing protein 2
- Cytochrome c oxidase assembly protein COX14 homolog
- HIG1 domain family member 2A, mitochondrial
- Zgc:123217
- Omega-amidase NIT2
Sequence:
MLASRALLAKQAAAMLVRQPACLMHHGGDWGNWGNTNIAVVFSGCGWWDGTDIHEAAYTMYHLSRNGARFQIFAPNQQQMHVMDHMKMQPSSSDNRNMMMESARFSHGQGMMQMNDLSKLDANSFDAVIFPGGHGIVKNMSTFSKDGKDCKLNNDVERVLKDFHRARKPIGLSSMAPLLACRVLPSLEVTMGYERDESSRWGRWPNTNMVQAVKSMGARHNTREPYEAYVDEKNKVISTPTFMWETDYHYHYIFDGIGNMVKHVMRMTAK
Protein: Cystinosin (O60931)
Organism: Homo sapiens (Human)
Function: Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes (By similarity). Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity (By similarity).
Subcellular location: [Isoform 1]: Lysosome membrane {ECO:0000269|PubMed:11150305, ECO:0000269|PubMed:11689434, ECO:0000269|PubMed:15128704, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:25753619, ECO:0000269|PubMed:28082515}; Multi-pass membrane protein {ECO:0000269|PubMed:36113465}. Melanosome membrane {ECO:0000269|PubMed:22649030}; Multi-pass membrane protein {ECO:0000269|PubMed:36113465}. Note=AP-3 complex is required for localization to the lysosome. {ECO:0000269|PubMed:25753619}.; SUBCELLULAR LOCATION: [Isoform 2]: Lysosome membrane {ECO:0000269|PubMed:18337546, ECO:0000269|PubMed:27148969}; Multi-pass membrane protein {ECO:0000269|PubMed:36113465}. Cell membrane {ECO:0000269|PubMed:18337546, ECO:0000269|PubMed:27148969}; Multi-pass membrane protein {ECO:0000269|PubMed:36113465}.
Interaction partners:
- Sedoheptulokinase
- Lysosomal amino acid transporter 1 homolog
- HCLS1-binding protein 3
- Transient receptor potential cation channel subfamily V member 1
- FGGY carbohydrate kinase domain-containing protein
Sequence:
MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEITFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRSSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKRPGYDQLN
Protein: Uncharacterized membrane protein YGL140C (P53120)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
- SAGA complex subunit SPT3
- Putative flavin carrier protein 3
- SAGA complex subunit NGG1
- SAGA complex subunit SGF29
- SAGA complex/transcription factor TFIID complex subunit TAF9
- SAGA complex subunit SGF11
- Regulator of rDNA transcription protein 6
- SAGA complex/transcription factor TFIID complex subunit TAF10
- SAGA complex/transcription factor TFIID complex subunit TAF12
Sequence:
MSLKSKLTKIQKLWLYYFPCDRILAKRICKSTVNTTVAFIFCLIPKITAHLGAAPAMLPMISVIVHPGRRVGGTIHGAIYCITGLIFGLAYAIFGRFLAQRCLGSSWHELTEAQQHVLHYKRYEAGLAILAVFEVIMLFFHGWMRSVSHYYFGIVFPLFVVVHFAFMDPLNETAGTIAKAYSTPFYLGIAMSIFWNLVLFPEWGTTYLGNTTIDAMNELHKSIDYSINFFIAVDPHNSSQLYSRDPVSLGKLLKMKSLISSKVNNCRVVLHECIYEFTYAYVSPTKLKPIISTLENLTVFINGLVNTCQLEFILLARHDNKLRPDDVAALTLPKNKEISFANAEKLLKVIDKLHPVIYSLHRTMSECMYIAKLVLAHAFDVKVSRVHSCSMFKDGNFPTFSNNANNLPNDVDIQNKINDLKQALEECKAKFKSEMLSFDIDIMSPSDEMFLLSSFLLNFRQTADSTLVIMESVKDILVKRQIQEKKGWLRGKRLWFLVLTNYETFSIWLKGDRNSVTENDTLKGTFNGNTNGFAHDTVIRRPDYEENELLSQKVSSNKNIVKDDASLDLPMTSEPKGNSSSTSDTSSSPLTLTKTTTFGTNRTSRRQGRFSFMSMLISIDKFCEVSHPHFRFGFQVAIALMLASFPMFIPKTRQWYIDYRGTWIGFVCILCLEPSVGGTFWVFFLRAVGVIFGAAWGYLSYVAAVNQTNPYLETVITVFGAIPGFYYLLGTPYVKAAIIEIISIYIVMLAAILPSQDDILTSFAKRCLAVGYGGGVALIVQVFFFPLKAREQLNEEISFVCGCISEMELLYATGLEGEQVASSMSEEKYKKIEKISKSAKEALARATAYKGLTRQEPRLKGEYTELENVFTQVIFIQKQIIERIDTISLLRKQNGSAVIEEFNSVVYPYRRQMVGSISCLMRALQEAFINKTPLPQFLPSARIAHRRLINKVRQTLRIRYPGQISNLSDKARKPNEGDYADGKDEDDDDNEGLVMKMNRRGQANTTANPHEYVLKEKFLSWNASSAASEEIIEYIEELLNLTKILVGVNEFKYGFLSRPLYEDWAAEAVTGFDNFINGKSNPMNTRRNRTPFDGTSIISEGNESLQSTNSNESQISPDSTRSYEPECPVAYEKNDNPAALNLLRIASHKAGQNADGLPKTFRNRAFSITSTSGQLSSLSRHSTLGNADPNYLNDDDESSDDDLPLALKMVLSHMKEKKD
Protein: Glucokinase regulatory protein (GKRP) (Glucokinase regulator) (Q14397)
Organism: Homo sapiens (Human)
Function: Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Mitochondrion {ECO:0000250|UniProtKB:Q07071}. Note=Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10456334}.
Interaction partners:
- Hexokinase-4
- N-acetylglucosamine-6-phosphate deacetylase
- N-acetylglucosamine-6-phosphate deacetylase
- Ketohexokinase
- Melatonin receptor type 1B
- Diacylglycerol kinase beta
- Glucose-6-phosphatase 2
- 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
- Transmembrane 6 superfamily member 2
Sequence:
MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEIFQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ
Protein: Scaffold attachment factor B1 (SAF-B1) (D3YXK2)
Organism: Mus musculus (Mouse)
Function: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (By similarity). Thereby acts as a negative regulator of cell proliferation (By similarity). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q15424}.
Interaction partners:
- Tight junction protein 2
- Heterogeneous nuclear ribonucleoprotein U
- Estrogen receptor
- Serine/arginine-rich splicing factor 1
- KH domain-containing, RNA-binding, signal transduction-associated protein 1
- RNA binding motif protein, X-linked-like-1
- RNA-binding motif protein, X chromosome
Sequence:
MAETLSGLGDASAAGAAAVSSAASETGTRRLSDLRVIDLRAELKKRNLDSSGNKSVLMERLKKAIEDEGGNPDEIEVTSECNKKMPKRPSKGRKPEDEGVEDNGLEENSGDGQEDVETSLENLQDMDMMDISVLDEADIDNGSVADCVEEEEEATLPEGLADSTELVEGDLKGLPEQLQEHAIDDKDTVNNVDTSSSDFTMLQEMEEASLEPENEKILDILGETCKSEPVKEEGSELEQPFAQATSSVGPDRKLAEEEDLFESCGHPEEEEEEEEEDQEEEQEEEGDLALASSSKSESPSTRCQWSEADAPLAVVKREPADAPGGGTGMDREPVGLEEPVEQSSTAAQLPEATSQELVRAPTAALSPEPQDSKEDVKKFAFDACNDVPAPPKESSASEGADQKMSSVEEDSDTKRLSREEKGRSSCGRNFWVSGLSSTTRATDLKNLFSRYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCISHLHKTELHGKMISVEKAKSEPTGKRVPDRRDGDSKKEKASTSDRSANLKREEKGERKDDAKKTDDGSTEKSKDADDQKPGPSERSRTTKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKESRKSRDSESRRERERSEREQRLQAQWEREERERLEIARERLAFHRHRLERERMERERLERERMHVEQERRREQERIHREREELRRQQELRYEQERRPAVRRPYEVDGRRDDAYWPEAKRAALDDRYHSDFSRQDRFHDFDHRDRGRYPNHSVDRREGSRSMMGDREGQHYPERHGGPERHGRDSRDGWGYGSNKRLSEGRGLPPPPRRDWGEHGRRLEDDRAWQGTADGGMMERDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHVIPRGGMQAGFGGQSRGSRPSDARFTRRY
Protein: PDZ domain-containing protein (O18302)
Organism: Caenorhabditis elegans
Interaction partners:
- Na
Sequence:
MSHCAACSGARLQAQTVLRVDPESEYFECEASAMEGGSGWTESLEKDFDKAFVSLDLLLGEVDSDQVEITYEGRQKMTSLSACFAQMMHKCQFMMHTISKQEKEMITMRAEVVEARAARQSMEKEVEQLMIQVHSLQCQLHSKTAPHESDMIKKKLETQLTQFRSELTQGLSTVCELEIARKECDRSKRTIQALETEVFGARLAAKYLDKELAGRIQQIQLLGRNMRGVEHDRLWNQLEAEIHLHRHKTVIRACRGRGNTKGLTAPLRHNFKSLRKRNGVGKSRKVVLSKHPHEGLGISITGGSEHALPIVISEIQPGQPADRCGQVFVGDAILSVNGYDLRTVKHQEAVDILSGQVQQGDLDLELVFVCPDEDSDDDGTVTIEHSDGSIYNLYSMEEPTSSRSSNNSDESRST
Protein: Homeobox protein Hox-A3a (Q8AWZ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Homeobox protein Hox-A5a
Sequence:
MQKATYCDGSAIYSGLPYQSANGLGYDASQQQYLQALHAESEYHRPACSLQSPGISAGLHTSNEMSEVCQQINGTQATVTDTSDNKQPPTAPSGPSSPSSLNQIPNIDSAAKNPVHVSPTPSTRKHIFPWMKESRQNTKQKSCSIISVESCAGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGLGMMPSPGAQSPHSPVSLSSGGGGGGGSAYLSSMHSLVNSVTYDSPSPASYNKPQSNTYSLPTSYPPLNNCPPPQKRYQGTGTATPEYDTHHIQGNNNYGTQVQGSPVYVSGGGGYSDSLVGMGASVFGLTHLPHPSQGNIDYNGAITMGNSHQQGACDSNPCTFTDLTPHYSQGRIQEAPKLTHL
Protein: Notopleural, isoform A (Notopleural, isoform B (EC 3.4.21.-)) (A1Z7M3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- VWFC domain-containing protein
- GH28601p
Sequence:
MGAQHTDTGTYTYTAASRAVEASDLTPKRIGAPAIATSRMPLTSLVFSLLTLGSLMLLTADASPVFVDNPSLAQFQSGRNIRHLPCIVRKSGRSGICMFAIDCIKQNGTHLGTCIDRFYFGSCCAMKEEASLFAPEINDNSIDQNTISHFSHESTTLPTSALFKLTTESSLSSSSSSGSSTAHHHTTNELLKNVTQSYLSTAKPAPVRTTSNGTLSTTRRPPLAHTTHKNSHYVVRTTMKPSAAPTTTITPTVKPPRRRTTTAKPVLTTAPIVEQRIETTSVPTKFVTFQIVETTTPAVTEPTHQQETTTTTTRRHTRPTGSSSVASRTTSKTTTTTTTTTTTTAAPPTTTSTRAATTTQRPTPPLRTTTSKPHKTHSSRRPAPAKKPVSTTTTTASGTQSTRKPADSLASGSTTANGTTATTLPARRPVTQTSSSSTTTTSTTSTITTTVFKDELPKNRTTTRLPERTTQAPRPRPKPTGEIVKVPALLAEPTTTTVTKGSSSSSSSSPKPPASSTTPLVTKKKPTTTNAPTTTTTTTTTTTTTTTPKPTRRTKPPTTTTTTTTKATTTTTKATTTTTTAKPLITTEPPTSAPLTTTTKKTGLITWTDVEAEPPTNASISNDWQPAPPSNWLPLTTESSETADKTSASTAPPSATDKVVISVATSVSEVETHGPGKPQKTTKPPKPSSTAKPTTTTTAAATTIVKTTEAPASSIELASSTSSYTDLGSDLAASSSSSTTTTTSSPTTAAETTDYSGEEPNTTTIEATGSTTVAPANALEGVDYKEVCGRRMFPEPRIVGGANAAFGRWPWQISLRQWRTSTYLHKCGAALLNENWAITAAHCVDNVPPSDLLLRLGEYDLAEEEEPYGYQERRVQIVASHPQFDPRTFEYDLALLRFYEPVIFQPNIIPVCVPDNDENFIGQTAFVTGWGRLYEDGPLPSVLQEVAVPVINNTICESMYRSAGYIEHIPHIFICAGWKKGGYDSCEGDSGGPMVLQRESDKRFHLGGVISWGIGCAEANQPGVYTRISEFRDWINQILQF
Protein: DNA polymerase delta interacting protein 2 (DNA-directed polymerase delta interacting protein 2) (E9PT51)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Cytochrome b-245 light chain
- NADPH oxidase 4
- NADPH oxidase organizer 1
- NADPH oxidase 2
- Neutrophil cytosolic factor 1
- NADPH oxidase activator 1
Sequence:
MAGCVARRALAVGSRWWSRSLATTRGSRPLCAVGGAGALPPVATATARRHLSSRNRAEGKVLETVGVFEVPKQNGKYETGQLFLHSVFGYRGVVLFPWQARLYDRDVASAAPEKAENPAGHGSKEVKGKTHTYYQVLIDARDCPHISQRSQTEAVTFLANHDDSRALYAIPGLDYVSHEDILPYTSTDQVPIQHELFERFLLYDQTKAPPFVARETLRAWQEKNHPWLELSDVHRETTESIRVTVIPFYMGMREAQNSHVYWWRYCIRLENLDSDVVQLRERHWRIFSLSGTLETVRGRGVVGREPVLSKEQPAFQYSSHVSLQASSGHMWGTFRFERPDGSHFDVRIPPFSLESNKDEKTPPSGLHW
Protein: Probable oxidoreductase (Q9HVQ8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable sulfite or nitrite reductase
- Sulfite reductase
- Adenosine 5'-phosphosulfate reductase
- Bifunctional enzyme CysN/CysC
- Methionine synthase
- Thiosulfate sulfurtransferase
- Probable 3-mercaptopyruvate sulfurtransferase
- L-cysteine desulfhydrase Cds1
- Cysteine synthase
- Cysteine synthase
Sequence:
MKKVWFQLHWFFGISAGLVLALMGVTGATLSFQDELMRALNPDVLVVQKRPEGVLPLDELVRRIEGAEPGRKVAFVWVEMDSDKAGRIFYTPPPGQRRGESRWIDPYTGAFVGEPRGEGFFNLMMQLHRFLAMGEYGKQVTAACTLILIFFCLSGLYLRWPRKVFDWRAWLTLDWSRKGRSFNWDLHAVAGTWCLALYLLAALTGLYWSYEWYRNGLFKLLDDAPAGQQAQRGKPGGRGERPADAAPLVVDYAAVWNSIRQAGGDRLQAYNLRLPPAGGQPATVFYRLTDAPHERAFNTLTLDPANGQVKSDQRYSDRSFGSQLLASVYALHVGSYFGMAGRILMMLASLAMPLFFITGWLLYLDRRRKKRAVRASRADLGGSAGASGEPWLIGYASQSGFAEQLAWQSAGQLQAAGLPVRVESLARLDAGQLAEARKALFVVSTFGDGEAPDSARGFERKVLGQAASLDGLSYALLALGDRQYEQFCGFARRMQGWLQGQGARSLFAPVEVDDGDAAALRQWQESLAEVTGGAAPAAWEAPAFEVWSLARRECLNPGSQGESTWLLDLRAPANSAIQWRAGDLLEIVPHQAPVRIREWLQRHNLDGQARVAVEGVEQSLEQALAGRLLPDSFEHLVGLHPQALLDALIPLSVRQYSIASLQSDGDLQLIVRQEQHADGSLGICSGWLTEYLPLGAALTLRLRRNAGFHLPEDDVPLILIGNGTGLAGLRSLLRASIAAGRKRNWLLFGERNFAHDYYCRAELEQALARGELQRLDLAFSRDQAEKIYVQDRLHEAADELRRWIDEGAALYVCGSLQGMAGGVDRVLREVLGEEALQRLADEGRYRRDVY
Protein: High-mobility group box 4 (Q6NSH1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MMNYVGKRKKRRKRDPQAPRRPPSSFLLFCQDHYAQLKRENPNWSVVQVAKATGKMWSTATDLEKHPYEQRVALLRAKYFEELELYRKQCNARKKYRMSARNRCRGKRVRQS