wanglab/gogpt-training-data huggingface dataset:
Protein: Pyruvate dehydrogenase complex protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (Pyruvate dehydrogenase complex component E3BP) (P16451)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Increased recombination centers protein 15
- Succinate--CoA ligase subunit alpha, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- Glutathione reductase
- Citrate synthase, peroxisomal
Sequence:
MLSAISKVSTLKSCTRYLTKCNYHASAKLLAVKTFSMPAMSPTMEKGGIVSWKYKVGEPFSAGDVILEVETDKSQIDVEALDDGKLAKILKDEGSKDVDVGEPIAYIADVDDDLATIKLPQEANTANAKSIEIKKPSADSTEATQQHLKKATVTPIKTVDGSQANLEQTLLPSVSLLLAENNISKQKALKEIAPSGSNGRLLKGDVLAYLGKIPQDSVNKVTEFIKKNERLDLSNIKPIQLKPKIAEQAQTKAADKPKITPVEFEEQLVFHAPASIPFDKLSESLNSFMKEAYQFSHGTPLMDTNSKYFDPIFEDLVTLSPREPRFKFSYDLMQIPKANNMQDTYGQEDIFDLLTGSDATASSVRPVEKNLPEKNEYILALNVSVNNKKFNDAEAKAKRFLDYVRELESF
Protein: Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed] (P07305)
Organism: Homo sapiens (Human)
Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:18993075}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:18993075}. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
Interaction partners:
- Histone H2B type 2-E
- Histone H2A type 2-C
- Histone H2A type 2-A
- Prothymosin alpha
- Cyclin-dependent kinase 2
- Histone H4
- Histone H3.2
- E3 ubiquitin-protein ligase RNF168
- Histone H3.1
- Cyclin-dependent kinase 1
Sequence:
MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATPKKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVKPKAKSSAKRAGKKK
Protein: Monocyte to macrophage differentiation factor 2 (Progestin and adipoQ receptor family member 10) (Progestin and adipoQ receptor family member X) (Q8IY49)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:22339580}; Multi-pass membrane protein {ECO:0000269|PubMed:22339580}.
Interaction partners:
- Anoctamin-5
- Dysferlin
Sequence:
MFAPRLLDFQKTKYARFMNHRVPAHKRYQPTEYEHAANCATHAFWIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTVFHTISWKKSHLRMVEHCLHMFDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTIYVFFFHERTGSCVQFLRGEACPKAGTACLPARYKLVELLCYVVMGFFPALVILSMPNTEGIWELVTGGVFYCLGMVFFKSDGRIPFAHAIWHLFVAFGAGTHYYAIWRYLYLPSTLQTKVSK
Protein: Troponin I, cardiac muscle (Cardiac troponin I) (Q6FGX2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQELEREAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQLHARVDKVDEERYDIEAKVTKNITEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKEDTEKENREVGDWRKNIDALSGMEGRKKKFES
Protein: Mitochondrial carrier protein, putative (Q38DX9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- ADP/ATP translocase
- ATP synthase alpha chain
- Reiske iron-sulfur protein, mitochondrial
Sequence:
MSAKNKTWDARYANPDIPHNNSYYLKCIGGGVLSCGLTHTAVCPLDVVKCNMQVNPEKFRGIGSGFKVLAAEDGFGAKGIWKGWLPTLIGYSMQGACKFGLYEVFKDFYANLAGQKAAKEYEGLIWLAGSASAEFFADVALCPMEMVKVKVQTSPSGTFPTSLGAAVATMRADPAAGFPFKSLVPLWSRQIPYTMAKFFFFEKVVRFFYSNVFTKPKEEYSKGTQLSITFASGYIAGIVCAIVSHPADMLVSARGKASNVGKSYGQIANEIGYGNLCTKGLMARIIMIGTLTGLQWWIYDTYKSTLGLGTSGGSGKK
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM metallopeptidase with thrombospondin type 1 motif, 16) (E7FFX0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- Dpy-19-like C-mannosyltransferase 3.
Sequence:
MAVLRALPNRRNYTERVYFVLFSSLIVLGCHQRTHCASAAAHHVKHRELLETLRLPHDTEYELVSPYEVDPEGQYISHAVSHQHRSKRSTDASTVHFRLQGLGREFQLDLRPSRGLIAAEFTVQTLGRSGTRSLQTLDGEMMCFYQGELRMQEHSSVALSTCMGMSGLIRTRDADYFLKPLHPHQALLENFSAPSPDHQPHILYKRPAPTNTRRTRRSSEPRPGDPAIPNRWRTSRQAEKNTHTLINPEEMQKTTHKNSTRRRQHYCGRRKKYMPKPPEEDIYIFPDEYKLMPRGKRDVVFKPETQPSLNVETLVVVDRKMMDNHGHENITTYVLTVLNMVSTLFKDGTIGGNINVVIVGLILLDEDQDGLVINHHADHTLNSFCQWQSGLSGREGRRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGNVCKKSVGNIMSPTLAGHNGLFSWSSCSRQYLNRFLSSAQATCLSDEPSAIQEYKYPEKLPGELYDADTQCKWQFGEKAKLCTLDFKKDICKALWCHRFGRKCETKFMPAAEGSACGPEMWCRGGQCVKQADAGPKAVDGQWSSWSGWSSCSRSCESGVTHRERVCSSPRPAHGGRFCEGSSRSYKLCNTDDCPANTVDFRAAQCAEFNSKPFRGWYYKWRPYTRVDDQDVCKLYCLAEGYDFFFALSSKVRDGTLCAQDSTDVCIDGICEKVGCDRVLGSNAVPDMCGVCKGDNSTCKIYKGQYSKQHHLSQYYRVVTIPAGARSIRVSELNSSSSYLALRNLQRKYYLNGAWTVDWPGRHSIAGAIFDYKRPYNRPESLSSSGPTNQTLVIEVLLQGWNPGVQWEYTLNREQKHNYSWAVVRSQCSSSCAGGQMVSKSICYRDLRFQVNSSYCSARSRPSSGVMSCNTQPCPASWSVQDWSSCSRSCGSGQQVRRVVCVQKTGPDQLETVADAQCPQPAPAHTHSCNTHSCPPAWSAGAWTQCSRKCGKGVMKRPVLCVLSNGVVLPDSSCADLLKPSVQEICFIKHCRKQRKAQWFVSTWTPCSVSCGEGLQQRVVKCAEKDYSGKYRELSQKKCQHVSRPSVDLQRVCVQAECPAAGTHWYSSPWSQCTVSCGGGVQIRSVQCLSLGRPASGCVLQMKPLMSQACNTAFCPQPELNDVVCKDHFSWCYLVPQHSVCNHKFYGKQCCKSCRQSKP
Protein: Splicing factor 3B subunit 6-like protein (Pre-mRNA branch site p14-like protein) (Q9FMP4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be necessary for the splicing of pre-mRNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Uncharacterized protein At3g23325
- Nuclear protein-like
- Uncharacterized protein At4g14342
- At2g32600/T26B15.16
- PHD finger-like domain-containing protein 5A
- Small nuclear ribonucleoprotein E
- Pliceosome associated protein-like protein
- Proline-rich spliceosome-associated
- Splicing factor 3B subunit 4
- Small nuclear ribonucleoprotein E
Sequence:
MTTISLRKSNTRLPPEVNRVLYVRNLPFNITSEEMYDIFGKYGAIRQIRIGCDKATKGTAFVVYEDIYDAKNAVDHLSGFNVANRYLIVLYYQHAKMSKKFDQKKSEDEITKLQEKYGVSTKDK
Protein: Histidine decarboxylase (HDC) (EC 4.1.1.22) (P23738)
Organism: Mus musculus (Mouse)
Function: Catalyzes the biosynthesis of histamine from histidine.
Interaction partners:
- Histamine N-methyltransferase
- Amine oxidase
- Amine oxidase
- Amine oxidase
- Diamine oxidase [copper-containing]
- Histidine ammonia-lyase
- Cytosolic non-specific dipeptidase
- Beta-Ala-His dipeptidase
- Carnosine synthase 1
- Histamine H1 receptor
Sequence:
MMEPCEYREYREYYRARGKEMVDYISQYLSTVRERQVTPNVQPGYLRAQLPASAPEEPDSWDSIFGDIERVIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNIMDWLAKMLGLPEYFLHHHPSSRGGGVLQSTVSESTLIALLAARKNKILAMKACEPDANESSLNARLVAYTSDQAHSSVEKAGLISLVKIRFLPVDDNFSLRGEALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDRLSELGPICASEGLWLHVDAAYAGTAFLCPELRGFLEGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGAATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRSDPSFEIPAKRHLGLVVFRLKGPNCLTESVLKEIAKAGQLFLIPATIQDKLIIRFTVTSQFTTKEDILRDWHLIQEAANLVLSQHCTSQPSPRAKNVIPPPPGTRGLSLESVSEGGDDPAQARKIIKQPGASLARREGGSDLETMPDPFDDCFSEEAPNTTKHKLSSFLFSYLSVQNRRKTTRSLSCNSVPMSAQKSLPADASLKNGGSFRARIFSGFPEQMMMMKKGAFKKLIKFYSVPSFPECSSQCARQLPCCPLEAMV
Protein: Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) (E9PK67)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVAMAEAEAGVAVEVRGLPPAVPDELLTLYFENRRRSGGGPVLSWQRLGCGGVLTFREPADAERVLAQADHELHGAQLSLRPAPPRAPARLLLQGLPPGTTPQRLEQHVQALLRASGLPVQPCCALASPRPDRALVQLPKPLSEADVRVLEEQAQNLGLEGTLVSLARVPQARAVRVVGDGASVDLLLLELYLENERRSGGGPLEDLQRLPGPLGTVASFQQWQVAERVLQQEHRLQGSELSLVPHYDILEPEELAENTSGGDHPSTQGPRATKHALLRTGGLVTALQGAGTVTMGSGEEPGQSGASLRTGPMVQGRGIMTTGSGQEPGQSGTSLRTGPMGSLGQAEQVSSMPMGSLEHEGLVSLRPVGLQEQEGPMSLGPVGSAGPVETSKGLLGQEGLVEIAMDSPEQEGLVGPMEITMGSLEKAGPVSPGCVKLAGQEGLVEMVLLMEPGAMRFLQLYHEDLLAGLGDVALLPLEGPDMTGFRLCGAQASCQAAEEFLRSLLGSISCHVLCLEHPGSARFLLGPEGQHLLQGLEAQFQCVFGTERLATATLDTGLEEVDPTEALPVLPGNAHTLWTPDSTEEVRELLATLEGLDLDGEDWLPRELEEEGPQEQPEEEVTPGHEEEEPVAPSTVAPRWLEEEAALQLALHRSLEPQGQVAEQEEAAALRQALTLSLLEQPPLEAEEPPDGGTDGKAQLVVHSAFEQDVEELDRALRAALEVHVQEETVGPWRRTLPAELRARLERCHGVSVALRGDCTILRGFGAHPARAARHLVALLAGPWDQSLAFPLAASGPTLAGQTLKGPWNNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHVPRASPDDPSGLPGRSPDT
Protein: Ankyrin repeat family protein (Q94CF4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
Sequence:
MARPSSASATTAIRPEDYSHSPVHYAVVLGDHGALTRLLSSLPKLGDPEQIRTESDSLSQERVADQISAVLDRRDVPSRETPLHLAVRLDDLFAARAISSAGGDISLQNASGWNPLQEAFCRRNSEVMKVLLRHHHRLAWCKWRRRLPRLIAVLRRMRDFYMEISFHFESSVIPFVGKIAPSDTYKIWKRDGNLRADTTLAGFDGLKIQRADQSFLFLGDGDESLDISPGSLLVLNRDDRKILDAFESAGAPISDSDIAGFCSQSSLYRPGMDVTKAELVGRTNWRRQEKMENVGEWKARVYEIQKVTFSFRSRKIVTGDGSEQVLPLELDEDDEGFLVAENPSFLAPPPRSQRRHSSFVKEDRDWISVGRKSVDVYPSAAPPPPRQSQSPRRSVSQFQPPRRSMAQVQPPRRSVAQAQPPRRSVALPSTVSPVNPPPSPQIKEKEFVKSLHPSVWLTEQFPLKTEELLPLLDILANKVKAVARMRDLLTTKFPPGTFPVKLSIPVVPTVKVVITFTKFVELPPAETFYTPLSSPRFLYSATAGEEDHSDGEKPDARNSISRPSTWLRLATGKGSHRRVEEEEQQTPDPFAIPIGYKWTSMSSSNSKSGNSSKMKKSKSTKRTK
Protein: Cdc2-related kinase (EC 2.7.11.22) (LP02532p) (SD02166p) (A1Z840)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD24704p
Sequence:
MSSLKSNDVDTNPAPDPQAPITRKGFLMSLNTGTPMPIPEQNLFGRCRPVSEFEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLDSIFLVMDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGELLLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNLLNILFIYNPKTRATAEECLKSKYFVDPPQACDPGMMPTFPQHRNNAAPAPAVQPPADIPISDLLNVFIKRQRME
Protein: Protein BRASSINAZOLE-RESISTANT 1 (Protein BIN2 SUBSTRATE 2) (Q8S307)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that binds to the brassinosteroid (BR) response element (BRRE) 5'-CGTG(T/C)G-3' in gene promoter. Regulates positively the brassinosteroid-signaling pathway. Mediates downstream growth responses and negative feedback regulation of brassinosteroid biosynthesis. Promotes growth. Modulates ovule initiation and development by monitoring the expression of genes related to ovule development (e.g. HLL, ANT, and AP2). Regulates negatively the abscisic acid (ABA) signaling pathway during the post-germination stage.
Subcellular location: Nucleus {ECO:0000269|PubMed:11970900, ECO:0000269|PubMed:12427989}.
Interaction partners:
- Shaggy-related protein kinase eta
- Transcription factor PIF4
- Auxin response factor 6
- Shaggy-related protein kinase iota
- DELLA protein RGA
- Lysine-specific demethylase ELF6
- Protein BRASSINOSTEROID INSENSITIVE 1
- DELLA protein GAI
- Serine/threonine-protein phosphatase BSU1
- BRI1 kinase inhibitor 1
Sequence:
MTSDGATSTSAAAAAAAAAAARRKPSWRERENNRRRERRRRAVAAKIYTGLRAQGDYNLPKHCDNNEVLKALCVEAGWVVEEDGTTYRKGCKPLPGEIAGTSSRVTPYSSQNQSPLSSAFQSPIPSYQVSPSSSSFPSPSRGEPNNNMSSTFFPFLRNGGIPSSLPSLRISNSCPVTPPVSSPTSKNPKPLPNWESIAKQSMAIAKQSMASFNYPFYAVSAPASPTHRHQFHTPATIPECDESDSSTVDSGHWISFQKFAQQQPFSASMVPTSPTFNLVKPAPQQMSPNTAAFQEIGQSSEFKFENSQVKPWEGERIHDVGMEDLELTLGNGKARG
Protein: Mitochondrial hinge protein, putative (Q57YU5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004137}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004137}; Intermembrane side {ECO:0000256|ARBA:ARBA00004137}.
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- Ubiquinol-cytochrome C reductase, putative
- Ubiquinol-cytochrome c reductase complex 14 kDa protein
- Reiske iron-sulfur protein, mitochondrial
Sequence:
MADEEPRDIKLDLEKDCLANNCQHKVLAYSACLERIKDIPSEKEPHCYHQYFDIVHCVDVCVDPKLWPTLV
Protein: Serine hydroxymethyltransferase 3, chloroplastic (AtSHM3) (AtSHMT3) (EC 2.1.2.1) (Glycine hydroxymethyltransferase 3) (Serine methylase 3) (Q94JQ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the interconversion of serine and glycine and directs the hydroxymethyl moiety of serine into the metabolic network of H4PteGlu(n)-bound one-carbon units.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:20518745}.
Interaction partners:
- Formate--tetrahydrofolate ligase
- Phosphoserine phosphatase, chloroplastic
- Glycine dehydrogenase
- Glycine dehydrogenase
- AICARFT/IMPCHase bienzyme family protein
- Aminomethyltransferase, mitochondrial
- Serine--glyoxylate aminotransferase
- Formyltetrahydrofolate deformylase 2, mitochondrial
- Formyltetrahydrofolate deformylase 1, mitochondrial
- Phosphoribosylglycinamide formyltransferase, chloroplastic
Sequence:
MQACCGGNSMASLQQPGRVQGSVFPPIMPPVTKFSQQLKFNISKPFRSSFLKRNLVSEMRASSVSLPNVEISSKEIPFEDYGLGEVDPEVRTIITKEKDRQFRSLELIASENFTSRAVMEAVGSCLTNKYSEGLPGKRYYGGNEYIDQLETLCQNRALAAFRLDSTKWGVNVQPLSGSPANFAVYTAILSPHDRIMGLDLPHGGHLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTATLFRPKLIIAGASAYSRDFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIFFRKDPINGVDLESAVNNAVFPGLQGGPHNHTIGGLAVCLKHAQSPEFKAYQKRVVSNCRALANRLVELGFKLVSGGSDNHLVLVDLRPMGMDGARVEKILDMASITLNKNSVPGDKSALVPGGIRIGSPAMTTRGLSEKDFVVVADFIKEGVEITMEAKKAAPGSKLQDFNKFVTSPEFPLKERVKSLKERVETFTSRFPIPGV
Protein: Pentatricopeptide repeat-containing protein At4g20090 (Protein EMBRYO DEFECTIVE 1025) (O49436)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in embryogenesis.
Interaction partners:
- AT4g00920 protein
- NC domain-containing protein-like protein
- Wall-associated receptor kinase-like protein
- Uncharacterized protein At4g00950
- ATPase, F1 complex, OSCP/delta subunit protein
- F-box protein At4g00893
- COP1-interacting protein 4.1
- H/ACA ribonucleoprotein complex non-core subunit NAF1
Sequence:
MPKCPIPIRISFFSYFLKESRILSSNPVNFSIHLRFSSSVSVSPNPSMEVVENPLEAPISEKMFKSAPKMGSFKLGDSTLSSMIESYANSGDFDSVEKLLSRIRLENRVIIERSFIVVFRAYGKAHLPDKAVDLFHRMVDEFRCKRSVKSFNSVLNVIINEGLYHRGLEFYDYVVNSNMNMNISPNGLSFNLVIKALCKLRFVDRAIEVFRGMPERKCLPDGYTYCTLMDGLCKEERIDEAVLLLDEMQSEGCSPSPVIYNVLIDGLCKKGDLTRVTKLVDNMFLKGCVPNEVTYNTLIHGLCLKGKLDKAVSLLERMVSSKCIPNDVTYGTLINGLVKQRRATDAVRLLSSMEERGYHLNQHIYSVLISGLFKEGKAEEAMSLWRKMAEKGCKPNIVVYSVLVDGLCREGKPNEAKEILNRMIASGCLPNAYTYSSLMKGFFKTGLCEEAVQVWKEMDKTGCSRNKFCYSVLIDGLCGVGRVKEAMMVWSKMLTIGIKPDTVAYSSIIKGLCGIGSMDAALKLYHEMLCQEEPKSQPDVVTYNILLDGLCMQKDISRAVDLLNSMLDRGCDPDVITCNTFLNTLSEKSNSCDKGRSFLEELVVRLLKRQRVSGACTIVEVMLGKYLAPKTSTWAMIVREICKPKKINAAIDKCWRNLCT
Protein: E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) (Q96MF7)
Organism: Homo sapiens (Human)
Function: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
Subcellular location: Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000269|PubMed:17589526}. Nucleus, PML body {ECO:0000269|PubMed:17589526}. Note=Localizes to PML nuclear bodies in ALT cell lines. {ECO:0000269|PubMed:17589526}.
Interaction partners:
- Non-structural maintenance of chromosomes element 3 homolog
- Structural maintenance of chromosomes protein 6
- Non-structural maintenance of chromosomes element 1 homolog
- Structural maintenance of chromosomes protein 5
- EP300-interacting inhibitor of differentiation 3
- Non-structural maintenance of chromosomes element 4 homolog A
- SUMO-conjugating enzyme UBC9
- Small ubiquitin-related modifier 4
- SMC5-SMC6 complex localization factor protein 2
- Structural maintenance of chromosomes protein 3
Sequence:
MPGRSSSNSGSTGFISFSGVESALSSLKNFQACINSGMDTASSVALDLVESQTEVSSEYSMDKAMVEFATLDRQLNHYVKAVQSTINHVKEERPEKIPDLKLLVEKKFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDEDIIVTQSQTNFTCPITKEEMKKPVKNKVCGHTYEEDAIVRMIESRQKRKKKAYCPQIGCSHTDIRKSDLIQDEALRRAIENHNKKRHRHSE
Protein: Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase) (Q2VPA6)
Organism: Mus musculus (Mouse)
Function: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (By similarity). Possesses both DNA unwinding and annealing activities (By similarity). Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA (By similarity). Efficiently unwinds substrates containing 3' overhangs or a D-loop (By similarity). In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing (By similarity). Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8TDG4}. Chromosome {ECO:0000250|UniProtKB:Q8TDG4}. Note=Localizes to sites of DNA damage; localizes to damaged replication forks. {ECO:0000250|UniProtKB:Q8TDG4}.
Interaction partners:
- DNA polymerase nu
- Fanconi anemia group D2 protein homolog
- Exonuclease 1
Sequence:
MEDGCPRIRRRVSVRKRNRGNLENLRASPTPAELQPAEDTEDEAAAGSRRRKTGSPEHAQENDSEEDMFGDYDSFTESSFLAHVDDLEQRYMQLPECGDRDADSGTKDLCSAGLKNNLRVTTVINLTDPETSEHGQKQSHLDVPAEPEPGSDLSFDVPSSQILYFENPQNSPEALGDPCTKKTNGDPQKSSHEELVSSHTEQPEPNNDFSNVRAASESSRRKSLKDHLKSTMAGNARAQTPAFPRSKHLREALLSEEISVAKKAIESPSDDLGPFYSLPSKVRDLYVQLKGIKKLYDWQHTCLTLRSVQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIVQEKISSLSSFGIELGFFVEEYAGSKGRFPPIKRREKKSLYIATIEKAHSLVNALIETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKVLYTSKTTQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYEVDSQAADGMTFSRLLSYKYSEALKKMDPDRLVALVTEVIPNYSCLVFCPSKKNCENVAEMLCKFLSKDYLNHREKEKCEVIKSLRNIGNGKVCPVLKRTVPFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVILRAPYVANTFLKRNQYKQMVGRAGRAGIDTAGESILLLQEKDKQQVLELISGPLETCCSHLVEEFTKGIQALFLSLIGLKIAASLGDIYQFMSGTFFGVQQKILLKEKSLWEITVDALEHLTEKGLLQKDSCGDNEGLECHFRITKLGQASFKGAIDLAYCDTLYRDLKKGLEGLVLESLLHLIYLTTPYDLAAQSEPDWMVYFKQFGQLSPTEQNVAALLGVSESFIGKKAAGQAVRKKVDKNVVNRLYLSFVLYSLLKETNVWSVSEKFNLPRGYIQNLLMGAASFSSCVLHFCEELEEFWVYKALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYNAGYRSIMHLANANPEVLVKTIDHLSRRQARQIVSSAKMLLHEKAEALQGEAEELLRLPADLPGLGGPSSERAGSHAGDVTLS
Protein: Alpha-actinin-4 (Non-muscle alpha-actinin 4) (P57780)
Organism: Mus musculus (Mouse)
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O43707}. Cytoplasm {ECO:0000250|UniProtKB:O43707}. Cell junction {ECO:0000269|PubMed:18332111}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:O43707}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:33228246}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (PubMed:33228246). {ECO:0000250|UniProtKB:O43707, ECO:0000269|PubMed:33228246}.
Interaction partners:
- Vinculin
- Alpha-actinin-1
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
- Zyxin
- Actin, cytoplasmic 2
- Nephrin
- Actin, cytoplasmic 1
- LIM domain only 7
- Catenin alpha-1
- MICAL-like protein 2
Sequence:
MVDYHAANQAYQYGPNSGGGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKQRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREALEKTEKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANMVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPSLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAAPGALDYKSFSTALYGESDL
Protein: DNA-directed RNA polymerase subunit Rpo8 (EC 2.7.7.6) (DNA-directed RNA polymerase, subunit G) (Q4JAY4)
Organism: Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00866}.
Interaction partners:
- DNA-directed RNA polymerase subunit Rpo5
- DNA-directed RNA polymerase subunit Rpo1N
- DNA-directed RNA polymerase subunit Rpo12
- DNA-directed RNA polymerase subunit Rpo6
- DNA-directed RNA polymerase subunit Rpo4
- DNA-directed RNA polymerase subunit Rpo3
- DNA-directed RNA polymerase subunit Rpo13
- DNA-directed RNA polymerase subunit Rpo1C
- DNA-directed RNA polymerase subunit Rpo11
- DNA-directed RNA polymerase subunit Rpo7
Sequence:
MMQGTCKISSIEKGALKNLYVVKMDCDNDLKIEFDITKELSIFSKDEEVTFIISREKPEYSEKDFCAHGYLFLERQQEDGSFIDEISLYGLIVKILSKNGLINSKLFKMMDHVYYCVKKKA