wanglab/gogpt-training-data huggingface dataset:
Protein: Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Q9NEN6)
Organism: Caenorhabditis elegans
Function: Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Negatively regulates lifespan.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62753}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62753}.
Interaction partners:
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein eS27
- Ribosomal Protein, Small subunit
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL14
Sequence:
MRLNFAYPATGLQKSFEVDEEKKLRLFFEKRMSQEVAIDALGDEWKGYVVRIGGGNDKQGFPMKQGILTNGRVRLLLKKGQSCYRERKNGERKRKSVRGCIVDANMSALSLVIVKKGDGEIEGLTDSVLPRKLGPKRASKIRKLFNLTKHDDVTKYVITHDKTFPDGVTKTIAPKIQRLITPARIARKKYLLRQKRNQKIKMRDDAAAYHKLLAKYSKEEHDAKIARRRSSASHHSESEVKKTSKK
Protein: RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (Q63484)
Organism: Rattus norvegicus (Rat)
Function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Membrane-associated after cell stimulation leading to its translocation. {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase mTOR
- Forkhead box protein O1
- Forkhead box O3
- PH domain leucine-rich repeat protein phosphatase 1
- 3-phosphoinositide-dependent protein kinase 1
- Tuberin
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- AKT1 substrate 1
- Forkhead box O4
- Hamartin
Sequence:
MSDVTIVKEDWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDPKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKDDDDGMDCMDNERRPHFPQFSYSASGRE
Protein: Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) (Q8C2B3)
Organism: Mus musculus (Mouse)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3 (By similarity). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10640276, ECO:0000269|PubMed:11279209, ECO:0000269|PubMed:11585834}. Cytoplasm {ECO:0000269|PubMed:11279209, ECO:0000269|PubMed:11585834}. Note=In the nucleus, it associates with distinct subnuclear dot-like structures (PubMed:10640276). Shuttles between the nucleus and the cytoplasm (PubMed:11279209, PubMed:11585834). In muscle cells, it shuttles into the cytoplasm during myocyte differentiation (PubMed:11279209). The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation (PubMed:11585834). {ECO:0000269|PubMed:10640276, ECO:0000269|PubMed:11279209, ECO:0000269|PubMed:11585834}.
Interaction partners:
- Histone acetyltransferase KAT5
- Forkhead box protein P3
- Nuclear receptor corepressor 1
- Nuclear receptor corepressor 2
- Hepatocyte nuclear factor 3-alpha
- Hypoxia-inducible factor 1-alpha
- NAD-dependent protein deacetylase sirtuin-1
- SUMO-conjugating enzyme UBC9
- Myocyte-specific enhancer factor 2A
- Histone H2A.Z
Sequence:
MHSPGAGCPALQPDTPGSQPQPMDLRVGQRPTVEPPPEPALLTLQHPQRLHRHLFLAGLHQQQRSAEPMRLSMDPPMPELQGGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPSSPSIPYRTLEPLDTEGAARSVLSSFLPPVPSLPTEPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPALGSEADGDRRTHSTLGPRGPVLGNPHAPLFLHHGLEPEAGGTLPSRLQPILLLDPSVSHAPLWTVPGLGPLPFHFAQPLLTTERLSGSGLHRPLNRTRSEPLPPSATASPLLAPLQPRQDRLKPHVQLIKPAISPPQRPAKPSEKPRLRQIPSAEDLETDGGGVGPMANDGLEHRESGRGPPEGRGSISLQQHQQVPPWEQQHLAGRLSQGSPGDSVLIPLAQVGHRPLSRTQSSPAAPVSLLSPEPTCQTQVLNSSETPATGLVYDSVMLKHQCSCGDNSKHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLTGLLAQRTFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQHGKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGTGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFAPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNKVDPLSEESWKQKPNLSAIRSLEAVVRVHRKYWGCMQRLASCPDSWLPRVPGADAEVEAVTALASLSVGILAEDRPSERLVEEEEPMNL
Protein: Ribonuclease T2 family protein (F4HUG9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ubiquitin-like superfamily protein
- Putative clathrin assembly protein At1g33340
- Putative clathrin assembly protein At5g65370
- Putative clathrin assembly protein At5g10410
- Putative clathrin assembly protein At4g25940
- Putative clathrin assembly protein At1g14686
- Ribosome biogenesis protein NOP53
- Putative clathrin assembly protein At1g14910
- Putative clathrin assembly protein At5g35200
- Putative clathrin assembly protein At5g57200
Sequence:
MRGIIIVSLLILQSLVVSSSQTEPDFNFFYWVNYWPGAICDSQKGCCPPTKGNTASDFIIHGLWPQFNNGTWPAFCDQTNLFDISKISDLVCQMEKKWTEWGVWACPSNETNLWEHEWNKHGTCVQSIFDQHSYFRTNLKFKHKVHLLNILIQKGIKPNDGFYSLDEIKNAIKCAIGFAPGIECNEDVKGNKQLFQIYICLDNYAKEFVECPYVPDKSCASKIKFPSLPERDSLNESLSVMSSVSTT
Protein: ESX-1 secretion-associated protein EspK (P9WJC1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: May act as a chaperone that facilitates EspB secretion through an interaction with EccCb1.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:17676952}.
Interaction partners:
- ESX-1 secretion-associated protein EspB
- ESX-1 secretion system protein EccE1
- 6 kDa early secretory antigenic target
- ESX-1 secretion system protein EccD1
- ESX-1 secretion-associated protein EspI
- ESX-1 secretion system protein EccCb1
- ESX-1 secretion system ATPase EccB1
- ESX-1 secretion-associated protein EspJ
- ESX-1 secretion-associated protein EspE
- ESAT-6-like protein EsxB
Sequence:
MSITRPTGSYARQMLDPGGWVEADEDTFYDRAQEYSQVLQRVTDVLDTCRQQKGHVFEGGLWSGGAANAANGALGANINQLMTLQDYLATVITWHRHIAGLIEQAKSDIGNNVDGAQREIDILENDPSLDADERHTAINSLVTATHGANVSLVAETAERVLESKNWKPPKNALEDLLQQKSPPPPDVPTLVVPSPGTPGTPGTPITPGTPITPGTPITPIPGAPVTPITPTPGTPVTPVTPGKPVTPVTPVKPGTPGEPTPITPVTPPVAPATPATPATPVTPAPAPHPQPAPAPAPSPGPQPVTPATPGPSGPATPGTPGGEPAPHVKPAALAEQPGVPGQHAGGGTQSGPAHADESAASVTPAAASGVPGARAAAAAPSGTAVGAGARSSVGTAAASGAGSHAATGRAPVATSDKAAAPSTRAASARTAPPARPPSTDHIDKPDRSESADDGTPVSMIPVSAARAARDAATAAASARQRGRGDALRLARRIAAALNASDNNAGDYGFFWITAVTTDGSIVVANSYGLAYIPDGMELPNKVYLASADHAIPVDEIARCATYPVLAVQAWAAFHDMTLRAVIGTAEQLASSDPGVAKIVLEPDDIPESGKMTGRSRLEVVDPSAAAQLADTTDQRLLDLLPPAPVDVNPPGDERHMLWFELMKPMTSTATGREAAHLRAFRAYAAHSQEIALHQAHTATDAAVQRVAVADWLYWQYVTGLLDRALAAAC
Protein: BBX high mobility group box domain containing (C9JA69)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKGSNRNKDHSAEGEGVGKRPKRKCLQWHPLLAKKLLDFSEEEEEEDEEEDIDKVQLLGADGLEQDVGETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYKWCPTTNKPVKSPTPTVNPRKKLWAFPSDSSRDLPSPKKAKTEEMPQLNFGMADPTQMGGLSMLLLAGEHALGTPEVSSGTCRPDVSESPELRQKSPLFQFAEISSSTSHSDASTKQCQTSALFQFAEISSNTSQLGGAEPVKRCGKSALFQLAEMCLASEGMKMEESKLIKAKESDGGRIKELEKGKEEKEIKMEKTDETRLQKEAEFEKSAKENLRDSKELRNFEALQIDDIMAIKMEDPKEIRKEELEEDHKCSHFPDFSYSASSKIIISDVPSRKDHMCHPHGIMIIEDPAALNKPEKLKKKKKKSKMDRHGNDKSTPKKTCKKRQSSESDIESVIYTIEAVAKGDWGIEKLGDTPRKKVRTSSSGKGSILDAKPPKKKVKSREKKMSKEKSSDTTKESRPPDFISISASKNISGETPEGIKAEPLTPMEDALPPSLSGQAKPEDSDCHRKIETCGSRKSERSCKGALYKTLVSEGMLTSLRANVDRGKRSSGKGNSSDHEGCWNEESWTFSQSGTSGSKKFKKTKPKEDCLLGSAKLDEEFEKKFNSLPQYSPVTFDRKCVPVPRKKKKTGNVSSEPTKTSKAIFSEDRNTMEPVHKVKNIPSIFNTPEPTTTQEPLVGSQKRKARKTKITHLVRTADGRVSPAGGTLDDKPKEQLQRSLPKATETDCNDKCSHNTEVGETRSSTPEMPAVSAFFSLAALAEVAAMENVHRGQRSTPLTHDGQPKEMPQAPVLISCADQ
Protein: Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (mLRP130) (Q6PB66)
Organism: Mus musculus (Mouse)
Function: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (By similarity). Binds single-stranded DNA.
Subcellular location: Mitochondrion {ECO:0000250}. Nucleus {ECO:0000269|PubMed:12071956}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus inner membrane {ECO:0000250}. Nucleus outer membrane {ECO:0000250}.
Interaction partners:
- SRA stem-loop-interacting RNA-binding protein
- Exportin-1
- Microtubule-associated protein 1S
- Small ribosomal subunit protein mS39
- Translational activator of cytochrome c oxidase 1
- Elongation factor G, mitochondrial
- DNA-directed RNA polymerase, mitochondrial
- Pentatricopeptide repeat-containing protein 2
- Poly
- Pentatricopeptide repeat-containing protein 1
Sequence:
MAALLRPARWLLGAAAAPRLPLSLRLPAGVPGRLSSVVRVAAVGSRPAAGERLSQARLYAIVAEKRDLQEEPAPVRKNSSQFDWALMRLDNSVRRTGRITKGLLQRVFESTCSSGSPGSNQALLLLRSCGSLLPELSLAERTEFAHKIWDKLQQLGVVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEGANIQPNRVTYQRLIAAYCNVGDIEGASKILGFMKTKDLPITEAVFSALVTGHARAGDMENAENILTVMKQAGIEPGPDTYLALLNAHAERGDIGQVRQILEKVEKSDHYFMDRDFLQVIFSFSKAGYPQYVSEILEKITYERRSIPDAMNLILFLATEKLEDTAFQVLLALPLSKDESSDNFGSFFLRHCVTLDLPPEKLIDYCRRLRDAKLHSSSLQFTLHCALQANRTALAKAVMEALREEGFPIRPHYFWPLLAGHQKTKNVQGIIDILKIMNKVGVDPDQETYINYVFPCFDSAQSVRAALQENECLLASSTFAQAEVKNEAINGNLQNILSFLESNTLPFSFSSLRNSLILGFRRSMNIDLWSKITELLYKDERYCSKPPGPAEAVGYFLYNLIDSMSDSEVQAKEERLRQYFHQLQEMNVKVPENIYKGICNLLNTYHVPELIKDIKVLVDREKVDSQKTSQVTSSDLESTLEKLKAEGQPVGSALKQLLLLLCSEENMQKALEVKAKYESDMVIGGYAALINLCCRHDNAEDAWNLKQEVDRLDASAILDTAKYVALVKVLGKHSRLQDAINILKEMKEKDVVIKDATVLSFFHILNGAALRGEIETVKQLHEAIVTLGLAKPSSNISFPLVTVHLEKGDLPAALEASIACHKKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIASNQVEALEKLVELTEKLFECDRDQMYYNLLKLYKISSDWQRADAAWTKMQEENIIPRERTLRLLAEILKTSNQEVPFDVPELWFGDDRPSLSPSSRSAGEDVTEKTLLSNCKLKKSKDAYNIFLKAEKQNVVFSSETYSTLIGLLLSKDDFTQAMHVKDFAETHIKGFTLNDAANSLLIIRQVRRDYLKGALATLRAALDLKQVPSQIAVTRLIQALALKGDVESIEAIQRMVAGLDTIGLSKMVFINNIALAQMKNNKLDAAIENIEHLLASENQAIEPQYFGLSYLFRKVIEEQMEPALEKLSIMSERMANQFALYKPVTDLFLQLVDSGKVDEARALLERCGAIAEQSSLLSVFCLRTSQKPKKAPVLKTLLELIPELRDNDKVYSCSMKSYALDKDVASAKALYEYLTAKNLKLDDLFLKRYAALLKDVGEPVPFPEPPESFAFYIKQLKEARESPS
Protein: T-box transcription factor TBX20 (T-box protein 20) (cTbx20) (Q8UW76)
Organism: Gallus gallus (Chicken)
Function: Acts as a transcriptional regulator involved in heart developmental processes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Interaction partners:
- Homeobox protein Nkx-2.5
- Transcription factor GATA-4
- Homeobox protein goosecoid
- Heart- and neural crest derivatives-expressed protein 2
- Insulin gene enhancer protein ISL-1
- Transcription factor GATA-5
- Myocyte enhancer factor 2C.
Sequence:
MEYTPPPKPQLSSRANAFSIAALMSSGSSKDKEAAESTIKPLEQFVEKSSCAQPLSDLSGLEPHGDFSGSPSALCTEPLIPTTPIIPSEEMAKISCSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLMKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGEDDLGDDSQATQSRGSAFTTSDNLSLSSWVSSSTSFPGFQHPQSLSALGTSTASIATPIPHPIQGSLPPYSRLGMPLTPSAIASSMQGTGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV
Protein: DExH-box ATP-dependent RNA helicase DExH12 (EC 3.6.4.13) (BRR2 homolog A) (AtBRR2A) (Pre-mRNA-splicing helicase BRR2A) (Protein EMBRYO DEFECTIVE 1507) (Q9SYP1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cell division cycle 5-like protein
- Tetratricopeptide repeat
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Pre-mRNA-processing factor 19 homolog 2
- At1g80930/F23A5_23
- Protein pleiotropic regulatory locus 1
- SNW/SKI-interacting protein
- Pre-mRNA-processing factor 17
- Pre-mRNA-processing factor 19 homolog 1
- Pre-mRNA-splicing factor
Sequence:
MANLGGGAEAHARFKQYEYRANSSLVLTTDNRPRDTHEPTGEPETLWGKIDPRSFGDRVAKGRPQELEDKLKKSKKKERDVVDDMVNIRQSKRRRLREESVLTDTDDAVYQPKTKETRAAYEAMLGLIQKQLGGQPPSIVSGAADEILAVLKNDAFRNPEKKMEIEKLLNKIENHEFDQLVSIGKLITDFQEGGDSGGGRANDDEGLDDDLGVAVEFEENEEDDEESDPDMVEEDDDEEDDEPTRTGGMQVDAGINDEDAGDANEGTNLNVQDIDAYWLQRKISQAYEQQIDPQQCQVLAEELLKILAEGDDRVVEDKLLMHLQYEKFSLVKFLLRNRLKVVWCTRLARAEDQEERNRIEEEMRGLGPELTAIVEQLHATRATAKEREENLQKSINEEARRLKDETGGDGGRGRRDVADRDSESGWVKGQRQMLDLESLAFDQGGLLMANKKCDLPPGSYRSHGKGYDEVHVPWVSKKVDRNEKLVKITEMPDWAQPAFKGMQQLNRVQSKVYDTALFKAENILLCAPTGAGKTNVAMLTILQQLEMNRNTDGTYNHGDYKIVYVAPMKALVAEVVGNLSNRLKDYGVIVRELSGDQSLTGREIEETQIIVTTPEKWDIITRKSGDRTYTQLVRLLIIDEIHLLHDNRGPVLESIVARTLRQIETTKENIRLVGLSATLPNYEDVALFLRVDLKKGLFKFDRSYRPVPLHQQYIGISVKKPLQRFQLMNDLCYQKVLAGAGKHQVLIFVHSRKETSKTARAIRDTAMANDTLSRFLKEDSVTRDVLHSHEDIVKNSDLKDILPYGFAIHHAGLSRGDREIVETLFSQGHVQVLVSTATLAWGVNLPAHTVIIKGTQVYNPEKGAWMELSPLDVMQMLGRAGRPQYDQHGEGIIITGYSELQYYLSLMNEQLPIESQFISKLADQLNAEIVLGTVQNAREACHWLGYTYLYIRMVRNPTLYGLAPDALAKDVVLEERRADLIHSAATILDKNNLVKYDRKSGYFQVTDLGRIASYYYITHGTIATYNEHLKPTMGDIDLYRLFSLSDEFKYVTVRQDEKMELAKLLDRVPIPIKETLEEPSAKINVLLQAYISQLKLEGLSLTSDMVYITQSAGRLVRALYEIVLKRGWAQLAEKALNLSKMVGKRMWSVQTPLRQFHGLSNDILMQLEKKDLVWERYYDLSAQELGELIRSPKMGKPLHKFIHQFPKVTLSAHVQPITRTVLNVELTVTPDFLWDEKIHKYVEPFWIIVEDNDGEKILHHEYFLLKKQYIDEDHTLHFTVPIFEPLPPQYFVRVVSDKWLGSETVLPVSFRHLILPEKYPPPTELLDLQPLPVTALRNPNYEILYQDFKHFNPVQTQVFTVLYNTNDNVLVAAPTGSGKTICAEFAILRNHHEGPDATMRVVYIAPLEAIAKEQFRIWEGKFGKGLGLRVVELTGETALDLKLLEKGQIIISTPEKWDALSRRWKQRKYVQQVSLFIVDELHLIGGQHGPVLEVIVSRMRYISSQVINKIRIVALSTSLANAKDLGEWIGASSHGLFNFPPGVRPVPLEIHIQGVDISSFEARMQAMTKPTYTAIVQHAKNKKPAIVFVPTRKHVRLTAVDLMAYSHMDNPQSPDFLLGKLEELDPFVEQIREETLKETLCHGIGYLHEGLSSLDQEIVTQLFEAGRIQVCVMSSSLCWGTPLTAHLVVVMGTQYYDGRENSHSDYPVPDLLQMMGRASRPLLDNAGKCVIFCHAPRKEYYKKFLYEAFPVESQLQHFLHDNFNAEVVAGVIENKQDAVDYLTWTFMYRRLPQNPNYYNLQGVSHRHLSDHLSELVENTLSDLEASKCIEVEDEMELSPLNLGMIASYYYISYTTIERFSSLLSSKTKMKGLLEILTSASEYDMIPIRPGEEDTVRRLINHQRFSFENPKCTDPHVKANALLQAHFSRQNIGGNLAMDQRDVLLSATRLLQAMVDVISSNGWLNLALLAMEVSQMVTQGMWERDSMLLQLPHFTKDLAKRCQENPGKNIETVFDLVEMEDEERQELLKMSDAQLLDIARFCNRFPNIDLTYEIVGSEEVNPGKEVTLQVMLERDMEGRTEVGPVDSLRYPKTKEEGWWLVVGDTKTNQLLAIKRVSLQRKVKVKLDFTAPSEPGEKSYTLYFMCDSYLGCDQEYSFSVDVKGSGAGDRMEE
Protein: Probable disease resistance protein RPP1 (Probable NAD(+) hydrolase RPP1) (EC 3.2.2.6) (Protein RECOGNITION OF PERONOSPORA PARASITICA 1) (F4J339)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TIR-NB-LRR receptor-like protein that confers resistance to the pathogen Hyaloperonospora arabidopsis (By similarity). Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death.
Interaction partners:
- Disease resistance protein RPP8
- Protein STRUBBELIG-RECEPTOR FAMILY 3
- Protein EDS1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- tRNA ligase 1
- Suppressor of RPS4-RLD 1
- Brassinosteroid-related acyltransferase 1
- Lipase-like PAD4
- Probable inactive ATP-dependent zinc metalloprotease FTSHI 1, chloroplastic
- RPM1-interacting protein 4
Sequence:
MGSVMSLGCSKRKATNQDVDSESRKRRKICSTNDAENCRFIQDESSWKHPWSLCANRVISVAAVALTNFRFQQDNQESNSSSLSLPSPATSVSRNWKHDVFPSFHGADVRRTFLSHIMESFRRKGIDTFIDNNIERSKSIGPELKEAIKGSKIAIVLLSRKYASSSWCLDELAEIMKCRQMVGQIVMTIFYEVDPTDIKKQTGEFGKAFTKTCRGKPKEQVERWRKALEDVATIAGYHSHSWRNEADMIEKISTDVSNMLNSFTPSRDFDGLVGMRAHMDMLEQLLRLDLDEVRMIGIWGPPGIGKTTIARFLFNQVSDRFQLSAIMVNIKGCYPRPCFDEYSAQLQLQNQMLSQMINHKDIMISHLGVAQERLRDKKVFLVLDEVDQLGQLDALAKETRWFGPGSRIIITTEDLGVLKAHGINHVYKVEYPSNDEAFQIFCMNAFGQKQPHEGFDEIAWEVTCLAGELPLGLKVLGSALRGKSKREWERTLPRLKTSLDGKIGSIIQFSYDVLCDEDKYLFLYIACLFNGESTTKVKELLGKFLDVKQGLHLLAQKSLISFDGERIHMHTLLEQFGRETSRKQFVHHGFTKRQLLVGARGICEVLDDDTTDSRRFIGIHLELSNTEEELNISEKVLERVHDFHFVRIDASFQPERLQLALQDLIYHSPKIRSLNWYGYESLCLPSTFNPEFLVELDMRSSNLRKLWEGTKQLRNLKWMDLSYSSYLKELPNLSTATNLEELKLRNCSSLVELPSSIEKLTSLQILDLENCSSLEKLPAIENATKLRELKLQNCSSLIELPLSIGTATNLKQLNISGCSSLVKLPSSIGDITDLEVFDLSNCSSLVTLPSSIGNLQNLCKLIMRGCSKLEALPININLKSLDTLNLTDCSQLKSFPEISTHISELRLKGTAIKEVPLSIMSWSPLADFQISYFESLMEFPHAFDIITKLHLSKDIQEVPPWVKRMSRLRDLSLNNCNNLVSLPQLSDSLDYIYADNCKSLERLDCCFNNPEIRLYFPKCFKLNQEARDLIMHTCIDAMFPGTQVPACFIHRATSGDSLKIKLKESPLPTTLRFKACIMLVKVNEELMSYDQTPMIVDIVIRDEHNDLKEKIYPSIYPSIYPLLTEHIYTFELDVEEVTSTELVFEFPQLNKRNWKIGECGILQRETRSLRRSSSPDLSPESSRVSSYDHCLRGD
Protein: UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Q0P8H3)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Function: Catalyzes the formation of UDP-glucuronic acid which is required for capsular polysaccharide synthesis. Does not catalyze the formation of glucuronamide moiety of the capsular polysaccharide.
Interaction partners:
- UDP-galactopyranose mutase
- dTDP-4-dehydrorhamnose 3,5-epimerase
- GDP-D-glycero-alpha-D-manno-heptose dehydrogenase
- Phosphatase
- Sugar transferase
- Sugar transferase
- Methyltransferase family protein
- Sugar transferase
- Sugar transferase
- Nucleotide sugar dehydratase
Sequence:
MKIVIVGIGYVGLANAILFSKNNENEVVLLDIDENKIQSINNHKSPIKDKLIEKFFVQNISKLHATSNIKEAYFNADFAVIATPTDYDEQLNFFDTRSIENVLKDIKNINSKINVIIKSTVPIGYTKTIKQKFNMSNIVFSPEFLREGSALYDSLYPSRIIIGDKSVLGKTIGDLFLKNIEKKNVDIFYMDSDEAESVKLFSNTYLAMRVGFFNEVDSYARKHNLNSADIIKGISADDRIGKYYNNPSFGYGGYCLPKDTKQLLANFYNIPNSLIKAIVETNEIRKKFITQLILEKKPNILGIYRLIMKQNSDNFRNSVIIDIIKYLQEYNSNIELIIYEPLVKEKKFLNIKVENDFNVFGAKVDLIIANRFDDKLKEIKDKVFSADVFYTDI
Protein: Barrier-to-autointegration factor B (Q66KV4)
Organism: Xenopus laevis (African clawed frog)
Function: Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA. Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging. Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner. Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface. Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity. Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses. Also involved in DNA damage response; acts by inhibiting the ADP-ribosyltransferase activity of PARP1. Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy.
Subcellular location: Nucleus {ECO:0000269|PubMed:19167377}. Chromosome {ECO:0000250|UniProtKB:O75531}. Nucleus envelope {ECO:0000269|PubMed:19167377}. Cytoplasm {ECO:0000250|UniProtKB:O75531}. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. {ECO:0000250|UniProtKB:O75531}.
Interaction partners:
Sequence:
MSSTSQKHRDFVAEPMGEKSVQCLAGIGDTLGRRLEEKGFDKAYVVLGQFLVLKKDEELFKEWLKDACSANAKQSRDCYGCLKEWCDAFL
Protein: Multidrug and toxin extrusion protein 2 (MATE-2) (MATE2-K) (Solute carrier family 47 member 2) (A7KAU3)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine or the antidiabetic drug metformin. Mediates the efflux of the endogenous compounds creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q86VL8}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q86VL8}; Multi-pass membrane protein {ECO:0000255}. Note=Detected in the renal urinary tubules. {ECO:0000250|UniProtKB:Q86VL8}.
Interaction partners:
- Solute carrier family 22 member 1
- Solute carrier family 22 member 2
- 3-hydroxyacyl-CoA dehydrogenase type-2
Sequence:
MNTAFAGFDENRAGRRAPGCTGRPAFGLGMDSQQDVVNLDQGGCCPALRKLLPRGFWDEARALFVLSGPLFLFQVLNFLTYVVGTVFCGHLGKVELASVTLGVAFVNVCGVSVGAGLSSACDTLMSQSFGSPNKKHVGVILQRGSLILLLCCLPCWALFLNTQHILLLFRQDPAVSRLTQDYAMIFIPGLPAIFLYSLLAKYLQNQGIVWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANTISQFVQAAFLFLHIVLKKLHLETWEGWSSQCLRDWGPFLSLAIPSMLMMCVEWWAYEIGSFLMGLLGVVDLSGQAIIYEVATVVYMIPMGLGMAVCVRVGTALGAADTLQAKRSAVSGLLCTAGTSLVVGTLLGLLNSQLGYIFTSDEEVIALVNQVLPIYIVFQLVEAVCCVFGGVLRGTGKQAFGAIVNAIMYYIVGLPLGIVLTFVVGMRIMGLWLGMLTCIFLAAVTFVVYAVQLDWKLAAEEAQKHAGLQQQQQQQQQQGAECTAPSPGPDKAVVSSVATGCNPGIALTMYSRPGCHVDFYGRPEAAPAPAAPASRLSVRQLLFRRGAALAASVAVLMAGLLVRVLTTGY
Protein: Amidohydrolase-related domain-containing protein (A6KWY3)
Organism: Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154) (Bacteroides vulgatus)
Interaction partners:
- Putative oxidoreductase
- Sorbitol dehydrogenase
- histidine kinase
- Bacterial surface antigen
- Fucose permease
Sequence:
MMDFNIIDAHSHLWLRQDTEVNGLPIRTLTNGRSLFMGEERQMVPPFMIDGRNSAEVFLSNMDYAQVSAAVVTQEFIDGIQNEYLAKVSHKYPDRFFVCGMCEFRKPGYLQQAKELISSGFKAIKIPAHRLFLKEGRVMLNSDEMMEMFHYMQEKDIILSIDLADGDTQVQEMKEIIQEYPQLRIAIGHFGMVTTPHWQEQIKLARHKNVMIESGGITWLFNSEFYPFHGAVKAIKEAADLVGMDKLMWGSDYPRTITAITYKMSYDFILKTTEMTQEEKALFLGKNAERFYGFKNLISLPYIKNMSE