wanglab/gogpt-training-data huggingface dataset:
Protein: Serrano protein (Q965D9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAATDGQIILAASRFGDATPVYLRDFSKQPLPAVAKIIKGQHQALGVPTLSAPSLQSTALFLSAGKKYQILAQPIKIKEGRKPTNVGAKVLIPETYGGYFELLSEDGRSTRCIDSVLELSRRRNARVLVRETFRCQQMNRTIHAGELLTTMNDNGKYLQCRNIKDEIINLPLDTKAKFSPIAREDSISGVHTVKNLLLKRMPVIVRLVHGSAPKGLKQPFVPELRLLGCVEIDRIFALPLQKDTDLVPVPLNAKIKLQRAKNMEQLEHFIEYSRFLDKAQRLLADARDRLQIVDLKLSEKEKKDSKFNSRNGGRLPVVMLPSAAGMASGLAESGYVLRKSASCDSWSKQQQQALSSSEIAEEYNEIDHIYDYVRGLTPLSKGLARFEPICESPTLRSHHTDSGSGNYCSLIRAPVHQQATTSGNNNYSSLESNKHSSSGGGHHPGSHHHHHHHVVNHYHHGHIQEDIKPVPPPIETIPGKKPAEKRQRPTLPKLYIKNAHSAGSSSNGNSTGTTHSTSHSHSHSHSHVHSHSHGQSQSQQQPPTPNGNTGNAVANASASAVAAAHHGSHGSHGSHPHPHPHASVHSHPHPHHGKVLTPNNHLPSKEALEPQSPLFHIRYKSLSSLQLTPDNNNCSSVTPPTISAHGKSSGAGVGSGATASGTPGTPGTPPDVGLKCGSILNVHGYLSSPHPLPLPLPHSRSSSSNNHHNPREGTLDSSRSGGRTSGDSNKLPEKKTRRLSRPRSLSNLVWDLRPSKEKSKKKLYIHHFDQRQQATLYL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q4R1K4)
Organism: Sus scrofa (Pig)
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}.
Interaction partners:
Sequence:
MDKCKENCISGLKTTVPPGDGPKRVPVTQHFPAQHLPSANSGQAQRVLCPSNSSQRLPSHTQKLVSSHKPVQNLKQKQSQATSGPRPVSRPLSNTQQSEQPQPAAPGNNPEKEAASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGAVYRELRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFAPEGARDLISRLLKHNPSHRPTLKEVLEHPWITANSKPASSHKKESTSKQP
Protein: TOX high mobility group box family member 3 (H3BTZ9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNMAEANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPALGMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQSHTQVSQYRQDPSLIMRSIVHMTDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSP
Protein: Myosin heavy chain 2 (F1LRV9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, myofibril {ECO:0000256|ARBA:ARBA00004657}.
Interaction partners:
Sequence:
AMSSDAEMAVFGEAAPYLRKSEKERIEAQNKPFDAKSSVFVVDAKESFVKATVQSREGGKVTAKTEGGATVTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEAPSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLAYLFSGAAAAAEAESGGGGGKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGYLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKENLAKAEAKRKELEEKMVALMQEKNDLQLQVQSEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDVENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMEVISKSKGNLEKMCRTLEDQVSELKTKEEEQQRLINELTAQRGRLQTESGEYSRQLDEKDSLVSQLSRGKQAFTQQIEELKRQLEEEVKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQIEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNVEAIKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQSKVKAYKRQAEEAEEQSNVNLAKFRKIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE
Protein: Inclusion membrane protein G (P0DPS6)
Organism: Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx)
Function: Inclusion membrane protein probably involved in early modification events of the chlamydial inclusion (By similarity). Binds to the host cell 14-3-3 beta (YWHAB); phosphorylation of Ser-166 is probably required (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:A0A0H3MGR4}. Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole membrane {ECO:0000305|PubMed:11260479}; Multi-pass membrane protein {ECO:0000255}. Note=Secreted, probably by a type III secretion system (By similarity). Localized in the inclusion membrane (By similarity). {ECO:0000250|UniProtKB:A0A0H3MGR4}.
Interaction partners:
- Inclusion membrane protein E
- Inclusion membrane protein F
- Inclusion membrane protein D
- Inclusion Membrane Protein B
- IncA family protein
- Inclusion Membrane Protein C
- IncA family protein
- Uncharacterized protein
- IncA family protein
Sequence:
MICCDKVLSSVQSMPVIDKCSVTKCLQTAKQAAVLALSLFAVFASGSLSILSAAVLFSGTAAVLPYLLILTTALLGFVCAVIVLLRNLSAVVQSCKKRSPEEIEGAARPSDQQESGGRLSEESASPQASPTSSTFGLESALRSIGDSVSGAFDDINKDNSRSRSHSF
Protein: Methylesterase 1 (AtMES1) (EC 3.1.1.-) (Q8S8S9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methylesterase shown to have carboxylesterase activity, methyl indole-3-acetic acid (MeIAA) esterase activity, methyl salicylate (MeSA) esterase activity and methyl jasmonate (MeJA) esterase activity in vitro. Required to convert methyl salicylate (MeSA) to salicylic acid (SA) as part of the signal transduction pathways that activate systemic acquired resistance in systemic tissue. MeSA is believed to be an inactive form that needs to be demethylated to exert a biological effect.
Interaction partners:
- Protein GIGAS CELL1
Sequence:
MSEEKRKQHFVLVHGSCHGAWCWYKVKPLLEAVGHRVTAVDLAASGIDTTRSITDIPTCEQYSEPLTKLLTSLPNDEKVVLVGHSFGGLNLAIAMEKFPEKISVAVFLTAFMPDTEHSPSFVLDKFGSNMPQEAWMGTEFEPYGSDNSGLSMFFSPDFMKLGLYQLSPVEDLELGLLLMRPGSLFINDLSKMKNFSDEGYGSVPRVFIVCKEDKAIPEERQRWMIDNFPVNLVMEMEETDHMPMFCKPQQLSDYFLKIADKFV
Protein: Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (PRx III) (Peroxiredoxin-3) (PRX-3) (Thioredoxin-dependent peroxiredoxin 3) (Q9Z0V6)
Organism: Rattus norvegicus (Rat)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity). Required for the maintenance of physical strength (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P35705}. Cytoplasm {ECO:0000250|UniProtKB:P30048}. Early endosome {ECO:0000250|UniProtKB:P30048}. Note=Localizes to early endosomes in a RPS6KC1-dependent manner. {ECO:0000250|UniProtKB:P30048}.
Interaction partners:
- Peroxiredoxin-5, mitochondrial
- Thioredoxin, mitochondrial
- Thioredoxin reductase 2, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- Thioredoxin
- Superoxide dismutase, mitochondrial
- Sulfiredoxin-1
- FA complementation group G
- Glutathione peroxidase 1
- Cytochrome c, somatic
Sequence:
MAAAAGRLLWSSVARPASTIFRSISASTVLRPVASRRTCLTDMLWSACPQAKFAFSTSSSFHTPAVTQHAPHFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDLTKQISRDYGVLLESAGIALRGLFIIDPNGVIKHLSVNDLPVGRSVEEPLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ
Protein: TATA-binding protein-associated factor MOT1 (TBP-associated factor MOT1) (EC 3.6.4.-) (Modifier of transcription 1) (P32333)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity.
Subcellular location: Mitochondrion. Nucleus. Note=Localized on chromatin. Specifically localized to the promoters of the genes it regulates.
Interaction partners:
- TATA-box-binding protein
- Negative cofactor 2 complex subunit alpha
- Transcription initiation factor IIB
- Negative cofactor 2 complex subunit beta
- SAGA complex subunit SPT3
- ISWI chromatin-remodeling complex ATPase ISW1
- DNA-binding protein REB1
- E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8
- Ubiquitin-like-specific protease 2
- Transcription initiation factor TFIID subunit 1
Sequence:
MTSRVSRLDRQVILIETGSTQVVRNMAADQMGDLAKQHPEDILSLLSRVYPFLLVKKWETRVTAARAVGGIVAHAPSWDPNESDLVGGTNEGSPLDNAQVKLEHEMKIKLEEATQNNQLNLLQEDHHLSSLSDWKLNEILKSGKVLLASSMNDYNVLGKADDNIRKQAKTDDIKQETSMLNASDKANENKSNANKKSARMLAMARRKKKMSAKNTPKHPVDITESSVSKTLLNGKNMTNSAASLATSPTSNQLNPKLEITEQADESKLMIESTVRPLLEQHEIVAGLVWQFQGIYELLLDNLMSENWEIRHGAALGLRELVKKHAYGVSRVKGNTREENNLRNSRSLEDLASRLLTVFALDRFGDYVYDTVVAPVRESVAQTLAALLIHLDSTLSIKIFNCLEQLVLQDPLQTGLPNKIWEATHGGLLGIRYFVSIKTNFLFAHGLLENVVRIVLYGLNQSDDDVQSVAASILTPITSEFVKLNNSTIEILVTTIWSLLARLDDDISSSVGSIMDLLAKLCDHQEVLDILKNKALEHPSEWSFKSLVPKLYPFLRHSISSVRRAVLNLLIAFLSIKDDSTKNWLNGKVFRLVFQNILLEQNPELLQLSFDVYVALLEHYKVKHTEKTLDHVFSKHLQPILHLLNTPVGEKGKNYAMESQYILKPSQHYQLHPEKKRSISETTTDSDIPIPKNNEHINIDAPMIAGDITLLGLDVILNTRIMGAKAFALTLSMFQDSTLQSFFTNVLVRCLELPFSTPRMLAGIIVSQFCSSWLQKHPEGEKLPSFVSEIFSPVMNKQLLNRDEFPVFRELVPSLKALRTQCQSLLATFVDVGMLPQYKLPNVAIVVQGETEAGPHAFGVETAEKVYGEYYDKMFKSMNNSYKLLAKKPLEDSKHRVLMAINSAKESAKLRTGSILANYASSILLFDGLPLKLNPIIRSLMDSVKEERNEKLQTMAGESVVHLIQQLLENNKVNVSGKIVKNLCGFLCVDTSEVPDFSVNAEYKEKILTLIKESNSIAAQDDINLAKMSEEAQLKRKGGLITLKILFEVLGPSILQKLPQLRSILFDSLSDHENEEASKVDNEQGQKIVDSFGVLRALFPFMSDSLRSSEVFTRFPVLLTFLRSNLSVFRYSAARTFADLAKISSVEVMAYTIREILPLMNSAGSLSDRQGSTELIYHLSLSMETDVLPYVIFLIVPLLGRMSDSNEDVRNLATTTFASIIKLVPLEAGIADPKGLPEELVASRERERDFIQQMMDPSKAKPFKLPIAIKATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDQYLRKEDYEKTRSVESRALPSLIICPPSLTGHWENEFDQYAPFLKVVVYAGGPTVRLTLRPQLSDADIIVTSYDVARNDLAVLNKTEYNYCVLDEGHIIKNSQSKLAKAVKEITANHRLILTGTPIQNNVLELWSLFDFLMPGFLGTEKMFQERFAKPIAASRNSKTSSKEQEAGVLALEALHKQVLPFMLRRLKEDVLSDLPPKIIQDYYCELGDLQKQLYMDFTKKQKNVVEKDIENSEIADGKQHIFQALQYMRKLCNHPALVLSPNHPQLAQVQDYLKQTGLDLHDIINAPKLSALRTLLFECGIGEEDIDKKASQDQNFPIQNVISQHRALIFCQLKDMLDMVENDLFKKYMPSVTYMRLDGSIDPRDRQKVVRKFNEDPSIDCLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRIGQKKVVNVYRIITKGTLEEKIMGLQKFKMNIASTVVNQQNSGLASMDTHQLLDLFDPDNVTSQDNEEKNNGDSQAAKGMEDIANETGLTGKAKEALGELKELWDPSQYEEEYNLDTFIKTLR
Protein: HMG box transcription factor Sox9b (SRY-box transcription factor 9b) (Transcription factor SOX-9b) (Q9DFH1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Forkhead box protein D3
- Aryl hydrocarbon receptor 2.
Sequence:
MNLLQRGLKMSVSGAPSPSLSEDSAGSPCASAGSGSDSETPRAEPPLHRDEQEKFPVCIRDAVSQVLKGYDWSLVPMPVRVSGSGKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNEGEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKSGSAESEDGEQTQISTNALFRALQRAETPDSSTGELHSPGEHSGQSQGPPTPPTTPKTDLPVCSKADLKRERERDRERPLQDGIDFGAVDIGELSSDVISNIEAFDVNEFDQYLPPHGAPGPAGAGFSSGYGSAAWMHKPLASSSMANAGEQHQQRAQIKTEQLSPGHYSQQPPQQQFYSAPYSRAQYTEYSEQHSAYYSPYPTFSYSRPPYTPAAAADTAHTHHWDPQPVYTQLSRP
Protein: ACD shelterin complex subunit and telomerase recruitment factor (Adrenocortical dysplasia protein homolog isoform 1) (A0A1D5NT19)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNPPKMKRRRMAELEPWIEKLIQNFGQNQTETVVKASVIGTCEISDSQRMDRTDACMLFLSDGIAMIPAVLSDAAWERLQELEDLDSFTSLLNHVAFIRSFELEFDMKPDLGSCQFYLKVNQMNTFCIALKRQQPPSCTTLQSVRDQIEKTWRSRGGGSESSVSGVSLSSLLDVWHSDIIVSILNDAMEKINVSATYSPSVATPTHWHRERLQRRAQEQFAIPVPFLLIPEEQRELMTADPGADSETPTGLAPPYEEPHPISTQSANQAVAVQDDAISDLCPDEGPSTLVQTRPEVLCGTGDLSRDTTSPWDMFTEEPGLLGRSTSSGSNDPDSESQSLLKEVPPLLIATSTQFSKQVSAGPSADGITLSQRPKPTQFSLSRSIGRSIRDPSQEQDKEPAQSPPSWLIHNTAPPSAPPPPRTKPSTPAPSKTRRVHSDGAPFSYLYHPKPQVASALSHFQVPGHLIQWAVCYLGTSDCADINAEAGS
Protein: Cytokinesis protein 3 (Q07533)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in cytokinesis by recruiting INN1 to the bud neck. Cooperates with INN1 to stimulate the synthesis of the primary septum (PS) by CHS2.
Subcellular location: Cytoplasm. Bud neck. Note=Found in association with the actin ring and the cortex at the mother-bud neck.
Interaction partners:
- Cytokinesis protein 2
- Ingression protein 1
- Ras GTPase-activating-like protein IQG1
- Myosin-1
- Chitin synthase 2
- High osmolarity signaling protein SHO1
- Protein BNI1
- Chitin synthase 3
- Paxillin-like protein 1
- Cell cycle protein kinase DBF2
Sequence:
MATNLTSLKPPFKVKARYGWSGQTKGDLGFLEGDIMEVTRIAGSWFYGKLLRNKKCSGYFPHNFVILLEERLNSSTENGRQPSKIVESFEKSNKVVIPPVPSRYSDERPRPKKKLSSSMPNSPKKPVDSLTKARKAKSKEMVNEKNIYNTQSSRHHNNSAPNLPLASHSKPQVRNFEESMNNPLPPLPPLPDLDNMRKTDKRAPKKSYSANDLHMARSSREYNYYKDNQKFYDGFIPEKRYSLEEDSISSGLFSNSQYLNDSACSSENSFALMSDFSATSAGSFARHKYAQSFSDSLQRSQNANGCSTKINDSQEFGDSNASSRNGKMGDILRKIIIPKRNTNIYSSSVSSPKSPKAYPKLPDIQNLNLSATPDEARDWIAVKCHLNRARTLTKYDKHPRYMRALEENRDLILHPQDSIYNGLNTNEVKGNTKPGLVDVELAELNIEYIDKMTWKRCIRDGTMTLDSWAQTTFSARYSTVLEKLRGIYIFCTEMFALTDDNGTSDFSAEPQNLEKILYRKHCTPYELTWLFKKLANSLGITCEIVIGFLKTPSAINWEFKYNHCWLRILVNKEWRFIDVILGNVTNPIHEFVNNRKIKKAENSYFLMAPLEMIYTHIPPREFEQHIVPSIDQLSALYLPLVFPSFFKNELKLYKFSTALSFLEDSEIYECSLEIPNDVEVFASVVIPTDNEEASSAYRNMELALTQIKKQKAESGRRIALIKAVLPPNVNKGSLYIHSGVRGTQTSIANIHPLSMMVPLTHKGSNMKYEFVIKIPSESIQKIELYIVEPQSRYLFVGNEYSFEVIQSPSDGIVYSSDEGPNQNRKQPMAIKSPSGRVHELVKSDPHFPYGTWKGSIKIKEPGVWSALVIADSGIGWSVFAEWLCV
Protein: Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L) (Cytochrome c oxidase subunit VIIaL) (P14406)
Organism: Homo sapiens (Human)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
Interaction partners:
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 6B1
- Cytochrome c oxidase subunit 6A1, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome c oxidase subunit 6C
- Cytochrome c oxidase subunit NDUFA4
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 7B, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
Sequence:
MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMILTVGGTAYAIYELAVASFPKKQE
Protein: Urea active transporter (P33413)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for active transport of urea.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Proline dehydrogenase, mitochondrial
- Urea amidolyase
- Allantoin permease
- Arginase
- Allantoate permease
- S-adenosylmethionine permease SAM3
- General amino-acid permease GAP1
- Malate synthase 2
- Ammonium transporter MEP2
- Protein ARG5,6
Sequence:
MGEFKPPLPQGAGYAIVLGLGAVFAGMMVLTTYLLKRYQKEIITAEEFTTAGRSVKTGLVAAAVVSSWIWCSTLLTSSTKEYADGIFGGYAYAAGACFQIIAFAILAIKTKQMAPNAHTYLELVRTRYGKIGHGCYLFYAIATNILVTSMLLTSGSAVFSDLTGMNTIASCFLLPVGVVVYTLFGGIKATFLTDYMHTCVIIIIVLVFAFKVYATSDVLGSPGKVYDLVREAAKRHPVDGNYQGEYMTMTSKSAGILLIINLIGNFGTVFLDNGYWNKAISASPAASLKAYAIGGLAWFAVPSLISLTMGLACLAVETSPNFPTYPDPLTSFQANSGLVLPAAAIAIMGKGGAVASLLMIFMAVTSAMSAELIAVSSVFTYDIYREYIDPRASGKKLIYTSHVACIFFGLAMSGFSVGLYYGGISMGYIYEMMGIIISSAVLPVVLTLCSKDMNLVAAVVSPILGTGLAIMSWLVCTKSLYKELTVDTTFMDYPMLTGNLVALLSPAIFIPILTYVFKPQNFDWEKMKDITRVDETAELVQADPDIQLYDAEANDKEQEEETNSLVSDSEKNDVRVNNEKLIEPNLGVVISNAIFQEDDTQLQNELDEEQRELARGLKIAYFLCVFFALAFLVVWPMPMYGSKYIFSKKFFTGWVVVMIIWLFFSAFAVCIYPLWEGRHGIYTTLRGLYWDLSGQTYKLREWQNSNPQDLHVVTSQISARAHRQSSHFGQVDEII
Protein: tRNA pseudouridine synthase D (EC 5.4.99.27) (tRNA pseudouridine(13) synthase) (tRNA pseudouridylate synthase D) (tRNA-uridine isomerase D) (Q57261)
Organism: Escherichia coli (strain K12)
Function: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Interaction partners:
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- 5'/3'-nucleotidase SurE
- Dual-specificity RNA pseudouridine synthase RluA
- tRNA pseudouridine synthase C
- tRNA pseudouridine synthase A
- tRNA pseudouridine synthase B
- Ribosomal small subunit pseudouridine synthase A
- Ribosomal protein S12 methylthiotransferase accessory factor YcaO
- Gamma-aminobutyraldehyde dehydrogenase
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Sequence:
MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGAQRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAAETELQALLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGDYAHIAE
Protein: Solute carrier family 19 member 1 (F1N2M7)
Organism: Bos taurus (Bovine)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSRPFPGSMALSVPEVEKQMPAEPQPGHEQQSWWCLVFFLCFYGFMAQMRPGESFITPYLLGPDKNFTQTQVTNEITPVLSYSYLAVLVPIFLLTDYLCYKPVLLLQGLSYVSVWLLLLFGSTVLHMQFMEFFFSITMAARIAYSSYIFSLVPPARYQRMASYSRASVLLGVFTSSVLGQLLVTVGRVAFSTLNYISLAFLTFSLVLALFLKRPKRSLFFNRGVPGPAGAAPSELDQMNPGQAKAAGAKPGWLPAAWRDSTFVRMPGELGRAVRLPQLRLWSLWWVFNSAGYYLIVYYVHILWNVVHPTTDTTRVYNGAADAASTLLGALTSFAAGFVKIRWALWARLVIAVVTVLQAGLVFLMYKTDDIWLCYAAFVLFRGSYQFLVPIATPVLPRRPDHTLALLARFMLRRPPAPVAMAAFPNCLMDVAPGLASHTSGTLHPPILTCSQPFSDRGFSFSRAPCPGLRHQHVPRHCSQDRHHPHRLRQAGPGPPGPLSVPCLLRVLPGALRRLLPCCRAGGPAPLPTEPPPAPAGGPRADESHAREGHAGRSPAPSPGGWCVCCGGAEPTV
Protein: Fumble, isoform G (EC 2.7.1.33) (M9NDE0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPEALHFTSIFDLIIKSGACTSKVQFAMPWFGMDIGGTLTKLVYFEPKDITPDEQDREAGILRNIRRYLTKNSAYGKTGHRDTHLQMDNVEIRKRRGSLHFIRFQTTDMGNFLSLAKQKGMAELVTTVCATGGGAFKFEQDFRDQVNMKLAKFDELDTLIKGILFADLHNRTECYYYENARDILKSEKQQFNFSQPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVSVSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQFNGELAAALNDGVEHSIHTESDSASEAAQTSSTADEPPEKAPTSKHSTR
Protein: Ribonuclease MRP protein subunit RMP1 (RNA-processing protein RMP1) (RNase MRP 23.6 kDa subunit) (Q12530)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ribonuclease P/MRP protein subunit POP5
- Ribonucleases P/MRP protein subunit POP3
- Ribonucleases P/MRP protein subunit POP6
- Ribonuclease P protein subunit RPR2
- Ribonucleases P/MRP protein subunit POP7
- Ribonucleases P/MRP protein subunit POP1
- Ribonucleases P/MRP protein subunit POP8
- Ribonuclease P/MRP protein subunit RPP1
- RNases MRP/P 32.9 kDa subunit
- Ribonuclease MRP protein subunit SNM1
Sequence:
MDEMDNVIRSLEQEYRLILLLNHRNKNQHRAASWYGSFNEMKRNCGQIITLFSSRRLQAKRLKDVEWVKLHRLLQRALFRQLKRWYWQFNGVIALGQFVTLGCTLVTLLANVRALYMRLWEINETEFIRCGCLIKNLPRTKAKSVVNDVEELGEIIDEDIGNNVQENELVITSIPKPLTENCKKKKKRKKKNKSAIDGIFG
Protein: Lymphotoxin-alpha (TNF-alpha) (TNF-beta) (Tumor necrosis factor) (Tumor necrosis factor ligand superfamily member 1) (Q08CQ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MKLESRALLDVEEGELPLPLVMVSRRKAGSSKSGVWRVFGIILAVGLCAAAAVCFTLHKTQGNQQDGSVLRLTLRDRISQGNFTSKAAIHLTGGYNSESKTLDWRDDQDQAFSSGGLKLVNREIIIPDDGIYFVYSQVSLHISCTSELTEEQVLMSHAVMRFSESYGGKKPLFSAIRSICTQEPESENLWYNTIYLGAAFHLREGDRLGTDTTTALLPMVENDNGKTFFGVFGL
Protein: GIPC PDZ domain containing family member 2 S homeolog (GIPC protein) (Q5HZ83)
Organism: Xenopus laevis (African clawed frog)
Interaction partners:
- DCC-interacting protein 13-beta
- Unconventional myosin-VI
- Somatotropin-A-like
Sequence:
MPLGLRVKKKNKSKEVSSKLVDSDEIANRASGSAGKVSSSANGAAGLPPPPVNLRPKLVFHTQLAHGSPTGRIEGFTNVKELYSKIAEAFLITPEEILFCTLNTHKIDMDKLLGGQIGLEDFIFAHVKGTKKEVEVLKSEDALGLTITDNGAGVAFIKRIKEESTIDKVKVINVGDHIEAINGKNIVGSRHYEVAKMLKELEKGQPFTLKLIEPLKAFEMIEPRARGGKTEGKISTGRETLRLRSKGPATVEEMPSVFEEKAIKKVDDLLESYMGIRDIELAATMVEAGRDKKNPDEFAVALDEALGDFAFPDEFVFDVWGAIGDAKQGRF
Protein: GTP cyclohydrolase 1 type 2 homolog (Radiation resistance protein YbgI) (P0AFP6)
Organism: Escherichia coli (strain K12)
Function: Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides.
Interaction partners:
- 5-oxoprolinase subunit B
- 5-oxoprolinase subunit C
- 5-oxoprolinase subunit A
- Endonuclease 8
Sequence:
MKNTELEQLINEKLNSAAISDYAPNGLQVEGKETVQKIVTGVTASQALLDEAVRLGADAVIVHHGYFWKGESPVIRGMKRNRLKTLLANDINLYGWHLPLDAHPELGNNAQLAALLGITVMGEIEPLVPWGELTMPVPGLELASWIEARLGRKPLWCGDTGPEVVQRVAWCTGGGQSFIDSAARFGVDAFITGEVSEQTIHSAREQGLHFYAAGHHATERGGIRALSEWLNENTDLDVTFIDIPNPA
Protein: Homeobox protein Hox-A6 (Homeobox protein Hox-1B) (P31267)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-A5
- Homeobox protein Hox-A7
- Homeobox protein Hox-C4
- Homeobox protein Hox-B7
- Homeobox protein Hox-B6
- Homeobox protein Hox-B5
- Homeobox protein Hox-B4
- Homeobox protein Hox-C5
- Homeobox protein Hox-C6
- Homeobox protein Hox-D4
Sequence:
MSSYFVNPTFPGSLPSGQDSFLGQLPLYQAGYDALRPFPASYGASSLPDKTYTSPCFYQQSNSVLACNRASYEYGASCFYSDKDLSGASPSGSGKQRGPGDYLHFSPEQQYKPDSSSGQGKALHDEGADRKYTSPVYPWMQRMNSCAGAVYGSHGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLINSTQPSGEDSEAKAGE