wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) (Q61151)
Organism: Mus musculus (Mouse)
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Interacts with cyclin G in vitro.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Shugoshin 1
- Apoptosis regulator Bcl-2
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
- Meiotic recombination protein REC8 homolog
- D
- Ryanodine receptor 2
Sequence:
MSSAPTTPPSVDKVDGFSRKSVRKARQKRSQSSSQFRSQGKPIELTPLPLLKDVPTSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITISRGCLTEQTYPEVVRMVSCNIFRTLPPSDSNEFDPEEDEPTLEASWPHLQLVYEFFIRFLESQEFQPSIAKKYIDQKFVLQLLELFDSEDPRERDYLKTVLHRIYGKFLGLRAFIRKQINNIFLRFVYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLVKVLIPLHTVRSLSLFHAQLAYCIVQFLEKDPSLTEPVIRGLMKFWPKTCSQKEVMFLGELEEILDVIEPSQFVKIQEPLFKQIAKCVSSPHFQVAERALYYWNNEYIMSLIEENSNVILPIMFSSLYRISKEHWNPAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQREKKKEKEREELWKKLEDLELKRGLRRDGIIPT
Protein: Glutathione S-transferase E14 (EC 2.5.1.18) (Protein noppera-bo) (Q7JYX0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Essential for ecdysteroid biosynthesis. May be involved in detoxification.
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
- Cholesterol 7-desaturase nvd
- Cytochrome P450 302a1, mitochondrial
- Short-chain dehydrogenase/reductase)
- Glutathione S transferase O1
- Glutathione S transferase E8, isoform A
- Glutathione S transferase E5
- Glutathione S transferase E7
- Glutathione S transferase T2
- Glutathione S transferase T1
Sequence:
MSQPKPILYYDERSPPVRSCLMLIKLLDIDVELRFVNLFKGEQFQKDFLALNPQHSVPTLVHGDLVLTDSHAILIHLAEKFDEGGSLWPQEHAERMKVLNLLLFECSFLFRRDSDFMSATVRQGFANVDVAHHERKLTEAYIIMERYLENSDFMAGPQLTLADLSIVTTLSTVNLMFPLSQFPRLRRWFTAMQQLDAYEANCSGLEKLRQTMESVGSFQFPSSSAVVTEKVE
Protein: GTPase Obg (EC 3.6.5.-) (GTP-binding protein Obg) (Q5L6R9)
Organism: Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus)
Function: An essential GTPase (4.1 pmol GTP/min). Cannot substitute endogenous obg in E.coli, has a partially dominant-negative phenotype upon overexpression in liquid culture leading to decreased growth rate in a concentration-dependent fashion, with 50% of cells being elongated. Binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01454, ECO:0000305|PubMed:21195156}. Note=Associates with 50S ribosomal subunit upon overexpression in E.coli. {ECO:0000269|PubMed:21195156}.
Interaction partners:
Sequence:
MFLDQITIELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGVGGSIIIESATHVYSFESYRNIRFLKAEDGRPGATNNRSGKNGKDLVLIVPEGTLLRDVETKEILYDFAKSGERLVVCRGGKGGKGNTFFKTSTNRAPTKATPGKPGEIRQVELELKLIADIGLVGFPNAGKSTLFNTLARTEVKVGAYPFTTLQPVLGLVPCQEKLYQKPWIIADIPGIIEGAHQNRGLGLDFLRHIERTRLLLFVIDICGCERSSPEEDLRILMDELVHYREDLADKNRIIALNKIDDLLPDERQERLESFQKLFPSETFVLVSGLTGEGVDLLNSLFTNKLAV
Protein: GPI-anchored adhesin-like protein (Q9FF91)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MASATATWTPTSLQLRLALSSGVRRKSPAVYLRPSRLARKSGYGIVCVSQKPEVDAWTGSDSSKSSADNLAGWDDSDNDDKKSSRVKKKSLIEGVVGAGVAGIILFLGLSYAAASFSKRTKKQEMHSLTSQQESMIQSSDEISSDEIKVANSEESNLKDEDKSIESNDVAQKSDEGSGEDKLLGKETSSFDGVMTDEADATESIPQNTPEADLMVNAETDPETAESEKIISESKSLLDSSTEPILLDAESSNLVGVENTNSEDPESLLNTEPTNVSDLENHVNSQKEDSLSSLSGIDAYAASGTVTELPEVSSQLDSTSKPQIVPLNDTETAFATAEELSEVNGTPEYFETSDWSSISDIDTTKELESSKSPVPESTDGSKDELNIYSQDELDDNRMLLEIPSGGSAFSSAGIPAPFMSVIVNPGKILVPVAADQIQCQAFAALQVLKVIETDTQPSDLCTRREYARWLISASSALSRNTTSKVYPAMYIENVTELAFDDITPEDPDFSSIQGLAEAGLIASKLSNRDLLDDVEGTFLFSPESLLSRQDLISWKMALEKRQLPEADKKMLYKLSGFIDIDKINPDAWPSIIADLSTGEQGIAALAFGCTRLFQPHKPVTKGQAAIALSSGEASDIVSEELARIEAESMAEKAVSAHNALVAEVEKDVNASFEKELSMEREKIEAVEKMAELAKVELEQLREKREEENLALVKERAAVESEMEVLSRLRRDAEEKLEDLMSNKAEITFEKERVFNLRKEAEEESQRISKLQYELEVERKALSMARSWAEEEAKKAREQGRALEEARKRWETNGLRVVVDKDLQETSSRETEQSIVLNEMERSSVEETERRAKTLMDKLKEMAGTVSGKSREVIFTVMEKIRLWITVLKEYAVNLGKRAGEMRDAAIVRAKGAAADVEQGTVQVSDKVKKMAEECRDGVGKISQRFKT
Protein: Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) (Q9JM76)
Organism: Mus musculus (Mouse)
Function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O15145}. Cell projection {ECO:0000250|UniProtKB:O15145}. Nucleus {ECO:0000250|UniProtKB:O15145}.
Interaction partners:
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 1B
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 1A
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin nucleation-promoting factor WAS
- Actin nucleation-promoting factor WASL
Sequence:
MPAYHSSLMDPDTKLIGNMALLPLRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPASKQEDEMMRAYLQQLRQETGLRLCEKVFDPQSDKPSKWWTCFVKRQFMNKSLSGPGQ
Protein: Chorismate mutase (CM) (EC 5.4.99.5) (O13739)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity). Acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P32178}.
Interaction partners:
- Chorismate synthase
- Putative prephenate dehydratase
- Probable prephenate dehydrogenase [NADP
- Pentafunctional AROM polypeptide
- Multifunctional tryptophan biosynthesis protein
- Probable anthranilate synthase component 1
- Aromatic amino acid aminotransferase C569.07
- Aromatic amino acid aminotransferase C1773.13
- Aromatic amino acid aminotransferase C56E4.03
- Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
Sequence:
MSLVNEKLKLENIRSALIRQEDTIIFNFLERAQFPRNEKVYKSGKEGCLNLENYDGSFLNYLLHEEEKVYALVRRYASPEEYPFTDNLPEPILPKFSGKFPLHPNNVNVNSEILEYYINEIVPKISSPGDDFDNYGSTVVCDIRCLQSLSRRIHYGKFVAEAKYLANPEKYKKLILARDIKGIENEIVDAAQEERVLKRLHYKALNYGRDAADPTKPSDRINADCVASIYKDYVIPMTKKVEVDYLLARLL
Protein: ADP-ribosylation factor 6 (EC 3.6.5.2) (P62332)
Organism: Rattus norvegicus (Rat)
Function: GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62330}. Cell membrane {ECO:0000250|UniProtKB:P62330}; Lipid-anchor {ECO:0000250|UniProtKB:P62330}. Endosome membrane {ECO:0000250|UniProtKB:P62330}; Lipid-anchor {ECO:0000250|UniProtKB:P62330}. Recycling endosome membrane {ECO:0000269|PubMed:26446845}; Lipid-anchor {ECO:0000250|UniProtKB:P62330}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:P62330}; Lipid-anchor {ECO:0000250|UniProtKB:P62330}. Cell projection, ruffle {ECO:0000250|UniProtKB:P62330}. Cleavage furrow {ECO:0000250|UniProtKB:P62330}. Midbody, Midbody ring {ECO:0000250|UniProtKB:P62330}. Early endosome membrane {ECO:0000250|UniProtKB:P62331}; Lipid-anchor {ECO:0000250|UniProtKB:P62331}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P62331}; Lipid-anchor {ECO:0000250|UniProtKB:P62331}. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body (By similarity). Recruitment to the midbody ring requires both activation by PSD/EFA6A and interaction with KIF23/MKLP1 (By similarity). After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles (By similarity). Myristoylation is required for proper localization to membranes: myristoylation on Lys-3 allows ARF6 to remain on membranes during the GTPase cycle (By similarity). {ECO:0000250|UniProtKB:P62330, ECO:0000250|UniProtKB:P62331}.
Interaction partners:
- Cytohesin-2
- Cytohesin-3
- Cytohesin-1
- Phospholipase D2
- Cytohesin 4
- ADP-ribosylation factor-binding protein GGA3
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
- Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
- Ras-related C3 botulinum toxin substrate 1
Sequence:
MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS
Protein: Cysteine-rich repeat secretory protein 58 (Q9FHD4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 like protein
- 1,8-cineole synthase 2, chloroplastic
- Cytochrome P450 like protein
- Baruol synthase
- Cytochrome P450 705A5
- Transcription factor bHLH129
- 1,8-cineole synthase 1, chloroplastic
- Marneral synthase
- NAD
- Protein GOLVEN 8
Sequence:
METTKKLFALLCLFVTMNQAISVSDPDDMETFCMKSSRNTTSNTTYNKNLNTLLSTLSNQSSFANYYNLTTGLASDTVHGMFLCTGDVNRTTCNACVKNATIEIAKNCTNHREAIIYNVDCMVRYSDKFFLTTLETNPSYWWSSNDLIPKSFGKFGQRLSDKMGEVIVRSSLLSSSFTPYYLMDTTRFDNLYDLESIVQCTPDLDPRNCTTCLKLALQELTECCGNQVWAFIYTPNCMVSFDTYNSSLPPLPPPSRSGSFSHRGNNKLLGGMVLAVSVSVFAFLSLV
Protein: tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (Q9U4Y0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
AQQHCPLNGKPDAEPVETGTDAQAQEGATAPTEDVVDPWNVASSNDAGVDYDKLIKRFGSSKIDEELIARFEKITGKPAHHFIRRGMFFSHRDLHTILTLREQGKPFYLYTGRGPSSGSLHVGHLVPFIMTKWLQETFDVPLVIQLTDDEKTLWKDLKVEDAIKLGRENAKDIVAIGFDVNKTFIFNNLEFVGKCPAMYQNIIRIQKCVTFNQVKGIFGFGDSDIIGKIGFPAAQAAPAISSTFPFIFGNRKVHCLIPCAIDQDPYFRMTRDVAPRLGFPKCALIHSTFFPALQGAKTKMSASDQNSAVYLTDTPKQIKNKINKYAFSGGRVTVEEHRKLGGVPEVDVSYQLLKFFLEDDAKLEEVRVAYSKGEMLTGEIKKLAVETLTPIVEQHQAARKLITDEVLDKYFELRPLKFGS
Protein: Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) (P97523)
Organism: Rattus norvegicus (Rat)
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Hepatocyte growth factor
- E3 ubiquitin-protein ligase CBL
- GRB2-associated-binding protein 1.
- Growth factor receptor-bound protein 2
- CD44 antigen
- Plexin-B1
- Receptor tyrosine-protein kinase erbB-3
- Catenin beta-1
- SHC-transforming protein 1
- GTPase NRas
Sequence:
MKAPTALAPGILLLLLTLAQRSHGECKEALVKSEMNVNMKYQLPNFTAETPIHNVVLPGHHIYLGATNYIYVLNDKDLQKVSEFKTGPVVEHPDCFPCQDCSSKANVSGGVWKDNVNMALLVDTYYDDQLISCGSVNRGTCQRHVLPPDNAADIQSEVHCMFSPLAEEESGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYPPDYSLHSISVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKYIHAFESNHFIYFLTVQKETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIGASPYDDILYGVFAQSKPDSAEPMNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRSDEYRTEFTTALQRVDLFMGRLNHVLLTSISTFIKGDLTIANLGTSEGRFMQVVLSRTAHFTPHVNFLLDSYPVSPEVIVEHPSNQNGYTLVVTGKKITKIPLNGLGCGHFQSCSQCLSPPYFIQCGWCHNRCVHSNECPSGTWTQEICLPAVYKVFPTSAPLEGGTMLTICGWDFGFKKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIVSNSRETTQYSAFSYVDPVITSISPRYGPHAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPGHTVSAEFPVKLKIDLADRVTSSFSYREDPVVSEIHPTKSFISGGSTITGIGKNLNSVSTPKLVIEVHDVGVNYTVACQHRSSSEIICCTTPSLRQLDLQLPLKTKAFFLLDGILSKHFDLTYVHDPMFKPFEKPVMISMGNENVVEIKGDDIDPEAVKGEVLKVGNKSCENLHWHSEALLCTVPSDLLKLNGGELNIEWKQAVSSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLVSGLFLWLRKRKHKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYLLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVPHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDSDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLVSKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSVSELVSRISSIFSTFIGEHYVHVNATYVNVKCVAPYPSLLPSQDNIDGEANT
Protein: Uncharacterized protein YjfJ (P0AF78)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YjfI
- UPF0719 inner membrane protein YjfL
- Uncharacterized protein YagL
- Uncharacterized protein YffL
- Uncharacterized protein YagN
- Prophage side tail fiber protein homolog StfR
- Uncharacterized J domain-containing protein DjlB
- Putative acid--amine ligase YjfC
- Inner membrane protein YqiJ
- Flotillin family inner membrane protein YqiK
Sequence:
MGILKSLFTLGKSFISQAEESIEETQGVRMLEQHIRDAKAELDKAGKSRVDLLARVKLSHDKLKDLRERKASLEARALEALSKNVNPSLINEVAEEIARLENLITAEEQVLSNLEVSRDGVEKAVTATAQRIAQFEQQMEVVKATEAMQRAQQAVTTSTVGASSSVSTAAESLKRLQTRQAERQARLDAAAQLEKVADGRDLDEKLAEAGIGGSNKSSAQDVLARLQRQQGE
Protein: Tropomodulin, isoform P (A0A0B4KHF2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSDIEDVFGGSAEETKPEPDAQSKTSVVTEHTEEVIPGETEKMVTETIDEDGDVVEETTEVTRKTVKRTMKITETSATTKTTTLTTPAKLYGKDLSEYDDVDVESLLAQLSPEEITILAKEVDPDDNFLPPDQRNSYECTKEATGPLNRKQLIEHINKQAIETPDQPEFEPFVQGKVRGKKWVPPPRDARDIEAEEQIAIDMGEEYEHALNDATQEEIIDLAAILGFHSMMNQDQYHASLLNKGQPVGLGWDGITKSTQQKLFPMDPPNNTDVEESIKRVKDDDSKLIDLNLNNIKNISDEKLEQLFAALPQNEHLEVLSLTNVGLTDKTALLLAAAIEKSKTLRVLNVETNFISPPVIVKLVQALLKCHTIEEFRASNQRSAVLGNKIEMEITDLVEKNSSLLRLGLHLEFNDARHRVAAHLQRNIDRSKLTLGIDR
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (O93596)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MMLANTENEQKQASGAALQVRLYCCRDEAGVISYPAGEYTAEELSVTAAKQCGVSPVHCALFGLMRERDRVWLPPNHIFKIEPSANETLLFRVRFYFPGWYGSGCSSARRYGLSRSSEAPVCDDITTAYLCAQWRSDFLSGAVSVPVSLEFQEECLGLAVLDIMRLAKEKGKSPVDIYNHSSYKSFLPKNMREHIQNQHLVTRKRIRFRFRRFLQQFGSCKAAPRELKLKYVVSLETLQPAFYSEHFRVSEASAGSVTIVVSGDRGIQWCRAAAPEPEDLQVYCDFSDVIDISIKQGTKDGSVENRIVTINRQDSQTLELEFQSLSEALSFVSLIDGYYRLTTDAHHYLCKEVAPPRLLEAIQINCHGPLSTEFAVSRLRRCEGQPGVYILRCSPKDYDRYFLSFMVEAEGQLELKHCLVLRSLSGEFVLSGARCSFSSLSELLARYQKEALRSDTHVFQLRRCCPPRSKDKSNLLVCRTHQGSEVCAPSSEHRLVNQMIFHKIHREDLQTTEGLGQGTFTQVFRGIRREVGDYGEVHKMEVVMKILDKSHRNYTESFFESASMMSQLSHKHLLLNYGICVCADEHIMVQEYVRFGSLDTYLKRNRNTINITWKLEVAKQLAWALHHLEEKSLTHGNVCARNVLVTREEDRKTGTPPFIKLSDPGISITVQPREILLERIPWVPPECVKDSRNLSLAADKWSFGTTLWEIYCGGEQPLAAYDTAKKLLFYEDKHQLPAPKWTELASVINSCMDYEPLHRPSFRALIRDLNSLYTPDYELLVESDTVPSRHRGPGLAGAFESQEPTQFQARHLIFLQLLGKGNFGSVEKCRYDPLQDNTGEVVAVKKLQHSTAEHLRDFEREIEILRSLQHENIVRYKGVCYSAGRNNLRLVMEFLPFGSLRDYLSKNRERFDHSKLLLYASQICKGMDYLAEKRYVHRDLATRNILVESEFRVKIGDFGLTKVLPQDKEYYTVREPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYSEKSCSPPAVFMEQMGEDKQGQMIVYHLIDLLKRNYRLPAPDGCPAEIHALMKQCWAPEPADRPLFRDLARTVEDIQDSQSG
Protein: Tail tube protein pb6 (TTP-pb6) (Major tail protein pb6) (MTP pb6) (Tail protein pb6) (Q6QGE2)
Organism: Escherichia phage T5 (Enterobacteria phage T5)
Function: Polymerizes to form the tail tube of the phage (Probable). Tail tube protein polymerization takes place around the tape measure protein (TMP-pb2) and is probably directed by chaperone proteins (Probable). The tail tube is involved in viral genome delivery during ejection (Probable).
Subcellular location: Virion {ECO:0000269|PubMed:36961893, ECO:0000305|PubMed:24198424}. Note=Main component of the tail tube, which is made of 40 stacked TTP-pb6 trimers. {ECO:0000269|PubMed:36961893, ECO:0000305|PubMed:24198424}.
Interaction partners:
Sequence:
MSLQLLRNTRIFVSTVKTGHNKTNTQEILVQDDISWGQDSNSTDITVNEAGPRPTRGSKRFNDSLNAAEWSFSTYILPYKDKNTSKQIVPDYMLWHALSSGRAINLEGTTGAHNNATNFMVNFKDNSYHELAMLHIYILTDKTWSYIDSCQINQAEVNVDIEDIGRVTWSGNGNQLIPLDEQPFDPDQIGIDDETYMTIQGSYIKNKLTILKIKDMDTNKSYDIPITGGTFTINNNITYLTPNVMSRVTIPIGSFTGAFELTGSLTAYLNDKSLGSMELYKDLIKTLKVVNRFEIALVLGGEYDDERPAAILVAKQAHVNIPTIETDDVLGTSVEFKAIPSDLDAGDEGYLGFSSKYTRTTINNLIVNGDGATDAVTAITVKSAGNVTTLNRSATLQMSVEVTPSSARNKEVTWAITAGDAATINATGLLRADASKTGAVTVEATAKDGSGVKGTKVITVTAGG
Protein: WRKY DNA-binding transcription factor 70 (SlWRKY70) (K4BIZ9)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways (By similarity). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Required for the resistance (R) gene Mi-1-mediated resistance to potato aphid (e.g. M.euphorbiae) and root-knot nematode (e.g. M.javanica).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- NPR1
- Uncharacterized protein.
- Transcription factor MYC2
Sequence:
MEDFLGENPHNRLIKELVEGKSFTVQLQTLLKQPNESVLAEELIRKIWGSFTQAITVLNSLGNSDNSLTQGQIEEVDQPNSGSELKKKKKEKQDRRGCYKRRKTSGSWMRESATMNDGCAWRKYGQKKILNSKYPRCYYRCTHKYDQECRATKQVQIIQENPIIMYHTTYFGNHTCNPTKIPKHTYNNHAMVKHSDSTVLKEEEEEEESKGQSDNASSIVDSNLWQDFMPSSPSAHDSTMAANYNSSYYEEIISSHDMEDWAKFGEIEAIEFC
Protein: Uncharacterized protein C1683.06c (Q9P6J4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uridine kinase
- IMP-specific 5'-nucleotidase 1
- Nicotinamide riboside kinase
- Putative cytidine deaminase
- Probable guanine deaminase
- Putative glutamine-dependent NAD
- Alkaline phosphatase
- Uridylate kinase
- Putative uracil phosphoribosyltransferase urg2
- Uracil phosphoribosyltransferase 2
Sequence:
MKIIIDTDPGQDDAITALLAIASPEIELLGVTTVAGNVPVSMTTRNALQMLDLAGRPDIPVYAGSNKPLLRAPITATHVHGASGFEGAVLPPPSRKENEGHAVDFIIDTLRNNEPGTITICTIGPLTNIALALNKAPEVIQRAKQIVMMAGAFSEVGNITPAAEFNIYVDPHAAQMVLSSGIPIVMMPLDITHQLHTSAKRIARMEALPNRVGPVVAAWLRMEKAYEAKKYGTDGGPLHDPNTVMWLLRPDIYSGRKVNVQIETQSELTMGMSVVDWWQVGLLPANVTFLRTVDDDEFYEVLIERLGRLP
Protein: GTPase-activating protein GYP2 (MAC1-dependent regulator) (Protein MIC1) (P53258)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Stimulates specifically the GTPase activity of SEC4, YPT6 and YPT36. Inactivates YPT6 during recycling between the endosome and the Golgi compartments.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12807768, ECO:0000269|PubMed:14562095}. Note=Distributed throughout the cytoplasm and accumulates in punctate structures, which concentrate in an actin-dependent manner at sites of polarized growth.
Interaction partners:
- Alpha-factor-transporting ATPase
- GTPase-activating protein GYP7
- GTPase-activating protein GYP1
- Lanosterol 14-alpha demethylase CYP51
- GTPase-activating protein GYP8
- GTPase-activating protein GYP6
- Pleiotropic ABC efflux transporter of multiple drugs
- Ras-related protein SEC4
- Transcription factor PDR1
- Delta
Sequence:
MSFFDSLRQKAPFLDKLADSFTPTLTRDEKFRLKYKLPANENILEDTNAEVSFATSIKDGKGHSDRVNNKGRKTAYVYSGRLFLTPHFLVFRDAFDHSSCVLILNISTIKRVERSPSESYEFALLVTLYTGAKVLIQFIGIRYRSEQFCDKLKLNLKENIPNAKTLPAFLETSYSEFLIAKNILGKKDITVPRAGLGQHFKYPGNPTMVKEKAKLRLWFDYFRENGRNLAVVQTPMFRKLIRIGVPNRMRGEIWELCSGAMYMRYANSGEYERILNENAGKTSQAIDEIEKDLKRSLPEYSAYQTEEGIQRLRNVLTAYSWKNPDVGYCQAMNIVVAGFLIFMSEEQAFWCLCNLCDIYVPGYYSKTMYGTLLDQRVFESFVEDRMPVLWEYILQHDIQLSVVSLPWFLSLFFTSMPLEYAVRIMDIFFMNGSITLFQVALAVLKINADDILQADDDGMFIAIIKHYFQTLGQSAHPDSSDIKYRQITKFQELLVTAFKEFSVISEEMAMHARHKYEKGIFQNIETFMKRTQLRHMPKTFNLSSDDLSNIYDMFYQSIETYKISMGTGSSNMGFEVFIQFLSKFCDSCRPCEKDKDPAFRKQKRNFLQRLFDNWDSAHIGELTLNDVVTGLDKLVTVDLLQAINYFFSLYDTDGDGELHREEVLQLSEGLLLLTEPWKSGRYVDLLTKKRIEDDIAENIIKESGGEIATMNQIELPTGVTIDEEKYKVEQAERYLKAASNFLQRSFEYAKAVDLAEEVNLIDLSDDEGEEKRTVKQKQLESIKANAALDPTHPKVIDLPTFRMIILADETYELFFSNTLRSSVHVDEHVNIDNKNKVLRSMFDGILADGKRVAEQVRRRVDSVATRSSIASVESTPTAAASSITTKEEKYDDLDDFTSEHQPENEELLQSSWFEIDDANETSTKAIQERSFEPLSANSSEEKSNLIEFEA