Protein: Cytoplasmic dynein 2 heavy chain 1 (Abnormal chemotaxis protein 3) (Q19542)
Organism: Caenorhabditis elegans
Function: Functions as a motor for intraflagellar retrograde transport in chemosensory neurons. Functions in cilia biogenesis.
Subcellular location: Cell projection, cilium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Interaction partners:
- WD_REPEATS_REGION domain-containing protein
- Dynein light intermediate chain
- Dynein light chain roadblock
- Lissencephaly-1 homolog
- Cytoplasmic dynein 2 light intermediate chain 1
- Intraflagellar transport protein 52 C-terminal domain-containing protein
- Osmotic avoidance abnormal protein 3
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein osm-1
- WD_REPEATS_REGION domain-containing protein
Sequence:
MSSDSKDQRKTYFLRVASYLLGLNIVEEKLKSTEPLEIFLDSNTNLLVFSRSEQKLELSNKMKSSAPSANVFRVVFYKTQSVPLNNDNFKSVVNVISANGTLNHVFLKSVQNVFGKELTEGNNMQLIAAVNELEESLLATVEMSGGGSLHDEIRSWKGQTGKPANDYNEAFKQLQLLVETMEERSIDELSELVECFEDTCDELWNCGTPYPQNRMKMLIEYGASYLCETITFKIDDSAIWRNDKVADQLRSAIDVCDQMLIIVRLLTAQTWKRNVEHTWEGDAMEMKFLNGFKDRLDEILSLKSLGGQLEELLEERGVREETEKTIETAMRGMAPLAYNPFTEPNWKSRLLVSERSIEGTIDRTLPILKQRLAPANGDSQSIVLSLEKLKSFLCRSNIKEKLQHEREMFLNRLVSMLSQKNQEFNEKSLQVDAKNFQFLTEVAARIVWIRQQTSQMESIRSLSKMMLNNISNYSAFASKLDEFIEKLQYAEKECFDDWCRETVGLIDNKNETINLETTGKIMYLEASNRELNVNYSDRLLRLLKEVRQLISLGFNIPSKIMSCANNGEKYYRFGVILKQIAHFYNTIDQQMIPSQQSLMLEEAIAFEKLVIPRKDASNSASKVTWNDPKQLEEFIVQLQSAEQKLSNRNRRLRNVHMELIEMVEKLMDLNIVKQNNEWKEIILKIRSKMKEEEIVHGAVKNNMKPWLIHWDFQLYKALLIQYEWGIESIQSQLSTISVSLVFADQKIQLRPTIEEIRSKYYKELCRFLRIPDKFRGVQEDENSTKFYAQMIERSMHLLPTVYEKAEQLMMKVETCDAIFVDWLVISQVDLEELIEENLKTAADWESQFKILKGKAREAERLPHELKFECILVSTAGVKSAIEDAIQRLYDALSWTLRHSISTTSQSISTFLSQAIEVLNTVPQSIDEIAEANAKHVIFAENNRRLKEEWKVMEEQLTLLRSVAGTGMEQIDNLEQTWDRFELMLDGHQSMIKDQVEVLKSNVETSVKGMKDEAEKLKARWEQFKPRNDALQGDREEMLKAIQFIKEKRVQWQQLSDGREKIEKECGQFGLEPPKMDIIDEIDEDIKQFEDNWLIYEMFNNELDTMSQEEWIVFRSKTYLFDEFLQKWMEKLKGTGSQTHMSVRLMKDVEHFKEVSSALKFCRGDVLSADHWHEMFRFLGLPRGTTIEKLKFADLLSVSKNIIENTDQLKQLNSRAQGEVAIRDAIQELTLWAAQTEFTLADYKHSNGQNLKIIKEWKESINSLKDSQALLQSLKSSPYYSQFTDKTAVWETRLADLDVFLAQMNEIQRKWIYLEPIFGRGALPSEASRFSRVDSEYRAILNDVSKDARLVSLCSRQSLKKSLEQIVDQLNRCQKALNQFLEQKRTAFPRFYFIGDDDLLEILGQSTNPQVIQTHMKKLFQGINRVQFSSTGETIISMVSSEGETVPLSKAVRIVPQVESWLQELSDEMRRTLKDLTAQAVADAQPSLAKYPSQVLCLAEEVKFSASIENNLNGSSDLNSFKSQLLEKLKAYTNMKVDDKVSDLKLKSLILDLIHHIDVVDQLLTNQAKSINSWTWQRQLRFYLVNGGIVLRQVSSEFEYTYEYQGNYAKLVHTPLTDKCYLTLTQAMYMGLGGNPYGPAGTGKTESVKALAALMGRQVLVFNCDEGIDVTSMGRIFTGIVECGAWGCFDEFNRLDSTVLSAVSMQIQTIQGAIKSRAGSCTFGGKNVQVNPNSAIFVTLNPAGKGYGGRQKMPDNLKQLFRAVVMGKPDNELISSTILYSEGFVDATALARKIVSVFQLSRQMLSKQQHYDWGLRALKVVLGGCGALRRTQTNKNETDLVVQALLLNTLSKLTFSDSERFNSLIDDIFSNVTKEMTKFEELVEPLGVAAQEMGIKLGDKQMEKVFQLYEQMRQRIGVVVVGAAGSGKSTIWKILQRSLILTKKPLKVTQFNPKAVNRSKLLGNMDMDTREWSDGIITMAAREVTKDTSVHHWIVCDGDIDPEWVEALNSVLDDNRLLTMPSGERIQFGSNVNFLFETDSLQFASPATVSRMGMIYISEEDVTPKDIVASWLVKTTEDLHADMPSWIEEHFWRCLKWVRSHKISGITSFAILKNGLTHLKASKTKTQFLVLLFNGFLPTVTPENRQEFAKGVVFQGMSVPDPKNICYDERIDGIMSYTDDVSQNVTKEEVEREDLRPFVQTADTQRYSDIIGSWLQSGNRESFLITGTTGCGKQQLLKHCFQNDPESQLASLYCSAQSSSSHLLQLIQQNCVQASNPTGRVWRPKDRPNMILFLKGINLPAPDKYGTNELLALLQQLLTYQGFFDHNLEWVSIENIQFVGSMNPIGDGAAVSISNRLFSLLRCVSLNTTDSSQLTSIYRTYLTPILEEVGERNSEIIANRMVDIYNKVQSNFRPTDSVVFLFSPRDLTNWVVSLLRHELDQGKLEAVICFEARRIFADRLPTENDKLKFEEILRNVIPISQANETVIFKEKVYVTTGTVVPGESNTGLPLTPINMSDFNQLLAKSINRFAFEIANFNCPLTSQLAFFCACIDRVLTGPGGHLFLPGRPGFGRRDSVRLVAHMHNIQVFSPPVTANFSAKQFDNELKNAITQAVTNNEHVVLILEDHQLRKNIFLQAINSLLASGNVPGLFTQQELDGLVALVSEAANQASFTGALQQFLAHRIRSLVHVVLILEVEANDFKINITENPAILKHCNVIFADRFDRNSLVEIPKIQMESQGITTTDAILTGFNDVLVNLPEHLSIQPIKYRQFVENFFQLLGYKRLTLSVRLERLKGGVSKLNEARDEVAKMQKKAGKKSKLLAEKQAEADEALKAITESMSGAEDQKLSMEQLKAATEKENVRIEEQKAKIDEQLKEVQPLIDEARRAVGSIKSESLSEIRSLRAPPEAVRDILQAVLLFMGILDTSWEAMRKFLSKSGVKDDIMNFDANRITNEIHKKVTALVKQKSNSFEEANAKRASAAAAPLAAWVKANLEYSKILEKIAPLEGEKNKLVKNLKKAEKQMENLSKGLQSVDEVVGELKRKFEVLMKEATQIKVDLDREQDTIRIAGTLVESLSGEFERWKIQIETFGEEQSKMELCSLITSAFITYLGGCSEKDRKSLLKSMCKMFNMPPTFKPLSFASLETEQLNWKTKGLPADQLSLENGSILFTSCHAPLIIDRSGQVSLFLSKFLEKSETFKAAQPDLMTQIELAIRFGKTIIIDDIVEFDSALIPILRKDLSSQGPRQVISFGGKSIDFNPDFKIYFCTRDEKVDIRPNSYVQLNIVNFTTTISALSAQLLDVAIHLEKPELEERSSSLLRDAELKKLELEGLEQLLLQQLASSQGNLLENTALLDSLNKSKESAEIITKSIVESEQLHKELTTQKDIYVPLSLFTSSLFFSFSNLQFHNPMYNYSVNTIMHLFGKTIKSCEDKSSTRVETLARQMQLTVFYHISRGIFRQDRLMFAVAFINATMPKMFQPKEWELFTGVLVDESTDLSALRVQWISPDRLQSLARIRTHLPSLFNNFQIQDDATWNEFSKTLQCENAFPKNVELKMTHFQKVLFIQAVKPERLYNCLMDFVLKTLNIPSINPPAFELKHIFQESESTEPILFILADGADPSQELSEFASSMNVPYHSISMGQGQEIAAYEAIRESASKGEWLCLNNLHLMLQAVPSIFKHLSLTTPHENFRLWLTTEGDARFPSMMLQQSLKITFEPPPGVRNNLLRTYTQIDRSTKNVITCQSIFVLAWLHALLQERRTFIPQGWTKFYEFGASDVRVAKSFVEQLTANKADWEFVRGILKFVIYGGRIENDFDFKVLDSYLNVLFCDEKINGRAGSQLVKGIDLLATTNVQEYIGHISKSVPSVDEPYLFGLPENIKYSWQIVEADRTISSIRTLALGDTKNALSDQSDKISQIVSLWKKLCQSDDLPKRELPTAIRSADPISEVLCLETINALSLIKQLHRSIGHVAKSMKTPSLASPAVQKTIQSLVFQQTPDEWDSMWAGPSDPADYLNVVVKKTRGTLQLFESSKSSSLLSSPIDFSDLFYPNIFLNALRQTTSRQIKIPLDQLILSSAWTPSQLPAKQCVQVQGLLLQGATFDSFLRETTVSSAAYSQAPIVFLAWTSESSSTITGEQIQVPVYSSSERSDLICSVNMPCRGADQWNIAAVALFLR