wanglab/gogpt-training-data huggingface dataset:
Protein: U1 small nuclear ribonucleoprotein 70 kDa homolog (U1 70K) (U1 snRNP 70 kDa homolog) (U1-70K) (U1 small nuclear ribonucleoprotein SNP1) (U1 snRNP protein SNP1) (Q00916)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in nuclear mRNA splicing.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Pre-mRNA-processing factor 39
- Protein LUC7
- Small nuclear ribonucleoprotein Sm D3
- U2 small nuclear ribonucleoprotein A'
- U1 small nuclear ribonucleoprotein A
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein-associated protein B
- U1 small nuclear ribonucleoprotein component PRP42
- U2 small nuclear ribonucleoprotein B''
- Small nuclear ribonucleoprotein F
Sequence:
MNYNLSKYPDDVSRLFKPRPPLSYKRPTDYPYAKRQTNPNITGVANLLSTSLKHYMEEFPEGSPNNHLQRYEDIKLSKIKNAQLLDRRLQNWNPNVDPHIKDTDPYRTIFIGRLPYDLDEIELQKYFVKFGEIEKIRIVKDKITQKSKGYAFIVFKDPISSKMAFKEIGVHRGIQIKDRICIVDIERGRTVKYFKPRRLGGGLGGRGYSNRDSRLPGRFASASTSNPAERNYAPRLPRRETSSSAYSADRYGSSTLDARYRGNRPLLSAATPTAAVTSVYKSRNSRTRESQPAPKEAPDY
Protein: N-alpha-acetyltransferase 38, NatC auxiliary subunit (I3L4V0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDSDGEREDSAAERARQQLEALLNKTMRIRMTDGRTLVGCFLCTDRDCNVILGSAQEFLKPSDSFSAGEPRVLGLAMVPGHHIVSIEVQRESLTGPPYL
Protein: Putative sodium-coupled neutral amino acid transporter 11 (Solute carrier family 38 member 11) (Q08AI6)
Organism: Homo sapiens (Human)
Function: Putative sodium-dependent amino acid/proton antiporter.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKQAGFPLGILLLFWVSYVTDFSLVLLIKGGALSGTDTYQSLVNKTFGFPGYLLLSVLQFLYPFIAMISYNIIAGDTLSKVFQRIPGVDPENVFIGRHFIIGLSTVTFTLPLSLYRNIAKLGKVSLISTGLTTLILGIVMARAISLGPHIPKTEDAWVFAKPNAIQAVGVMSFAFICHHNSFLVYSSLEEPTVAKWSRLIHMSIVISVFICIFFATCGYLTFTGFTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPMECFVTREVIANVFFGGNLSSVFHIVVTVMVITVATLVSLLIDCLGIVLELNGVLCATPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMVFGFVMAITNTQDCTHGQEMFYCFPDNFSLTNTSESHVQQTTQLSTLNISIFQ
Protein: Vacuolar iron transporter homolog 1 (Protein NODULIN-LIKE 1) (Vacuolar iron transporter-like 1) (AtVTL1) (Q9LPU9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable vacuolar iron transporter involved in the transfer of iron ions from the cytosol to the vacuole for intracellular iron storage. Involved in regulation of cellular iron homeostasis. Vacuolar iron storage is required for seed embryo and seedling development.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:25360591}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Vacuolar iron transporter 1
- Cation-chloride cotransporter 1
- Ferric reduction oxidase 3, mitochondrial
- Uncharacterized protein At4g06744
- Probable LRR receptor-like serine/threonine-protein kinase At5g48740
- Transcription factor bHLH47
- Probable LRR receptor-like serine/threonine-protein kinase At1g67720
- Protein ZINC INDUCED FACILITATOR 1
- Solute carrier family 40 member 2
Sequence:
MESHNVSNSLNLDMEMDQEKAFDYSKRAQWLRAAVLGANDGLVSTASLMMGVGAVKQDVKVMILSGFAGLVAGACSMAIGEFVSVYSQYDIEVAQMKRENGGQVEKEKLPSPMQAAAASALAFSLGAIVPLMAAAFVKDYHVRIGAIVAAVTLALVMFGWLGAVLGKAPVFKSSARVLIGGWLAMAVTFGLTKLIGTHSL
Protein: Syntaxin-1A homolog (Uncoordinated protein 64) (O16000)
Organism: Caenorhabditis elegans
Function: Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12973353}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P32851, ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:12973353, ECO:0000269|PubMed:18596236}. Cell projection, dendrite {ECO:0000269|PubMed:12973353, ECO:0000269|PubMed:18596236}. Perikaryon {ECO:0000269|PubMed:18596236}.
Interaction partners:
- Synaptobrevin-1
- Acetylcholine regulator unc-18
- Synaptosomal-associated protein
- Synaptotagmin-1
- Alpha-soluble NSF attachment protein
- Lethal giant larvae homologue 2 domain-containing protein
- Phorbol ester/diacylglycerol-binding protein unc-13
- Synaptotagmin 2
- Syntaxin-binding protein 1
- V-SNARE coiled-coil homology domain-containing protein
Sequence:
MTKDRLSALKAAQSEDEQDDDMHMDTGNAQYMEEFFEQVEEIRGSVDIIANNVEEVKKKHSAILSNPVNDQKTKEELDELMAVIKRAANKVRGKLKLIENAIDHDEQGAGNADLRIRKTQHSTLSRRFVEVMTDYNKTQTDYRERCKGRIQRQLDIAGKQVGDEDLEEMIESGNPGVFTQGIITDTQQAKQTLADIEARHNDIMKLESSIRELHDMFMDMAMLVESQGEMVDRIEYNVEHAKEFVDRAVADTKKAVQYQSKARRKKICILVTGVILITGLIIFILFYAKVL
Protein: DNA-directed RNA polymerase 1, mitochondrial (EC 2.7.7.6) (NsRpoT-A) (T7 bacteriophage-type single subunit RNA polymerase 1) (Q93Y94)
Organism: Nicotiana sylvestris (Wood tobacco) (South American tobacco)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11722843, ECO:0000269|PubMed:12061895}.
Interaction partners:
- rRNA adenine N
- rRNA adenine N
- Protein TPLATE
- rRNA adenine N
Sequence:
MWRYISKQAYSRKFRNSHDSALLGFSQYSSSFGKTRPLQCLCEESTTNPNLGLSQNSIFSRISRKVRHLEGICEESSKNPHLGLSQNSLFSSVKGDFRVCGKRGSGSLGFLRSYGSAAEAIASTSEEDIDEIQELIEEMNKENEALKTNLQPKQPKTIGGMGVGKYNLLRRRQIKVETEAWEEAAKEYQELLMDMCEQKLAPNLPYMKSLFLGWFEPLRDAIAAEQKLCDEGKNRGAYAPFFDQLPAEMMAVITMHKLMGLLMTGGGTGSARVVQAASHIGEAIEHEARIHRFLEKTKKSNALSGDLEDTPGDIMKERERVRKKVKILMKKQKLQQVRKIVKQQDDEKPWGQDNLVKVGCRLIQILMETAYIQPPNDQLDDCPPDIRPAFVHTLKTVETMKGSRRYGVIQCDPLVRKGLDKTARHMVIPYMPMLVPPQSWLGYDKGAYLFLPSYIMRTHGAKQQREAVKRVPKKQLEPVFQALDTLGNTKWRLNRKVLGIVDRIWASGGRLADLVDREDVPLPEEPDAEDEAQIRKWKWKVKGVKKENCERHSQRCDIELKLAVARKMKDEDGFYYPHNLDFRGRAYPMHPYLNHLGSDLCRGILEFAEGRPLGKSGLRWLKIHLANVYGGGVDKLSYEGRVAFSENHVEDIFDSAERPLEGKRWWLGAEDPFQCLATCINIAEALRSPSPETAISYMPIHQDGSCNGLQHYAALGRDTLGAAAVNLVAGDKPADVYSGIAARVLDIMKRDAAKDPANDPNVMRARLLINQVDRKLVKQTVMTSVYGVTYIGARDQIKRRLKERGVIEDDNELFAAACYAAKTTLTALGEMFEAARSIMSWLGDCAKIIAMENHPVRWTTPLGLPVVQPYRKLGRHLIKTSLQILTLQRETDKVMVKRQRTAFPPNFVHSLDGSHMMMTAIACKESGLSFAGVHDSYWTHASDVDQMNKILREKFVELYDAPILENLLESFQQSFPDLQFPPLPERGDFDLREVLESPYFFN
Protein: MHD domain-containing protein (O01755)
Organism: Caenorhabditis elegans
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Interaction partners:
- AP-1 complex subunit gamma
- AP complex subunit sigma
- AP complex subunit beta
- AP-1 complex subunit mu-1-I
- Importin N-terminal domain-containing protein
- ADP-ribosylation factor
- ADP-ribosylation factor 1-like 1
- Junctophilin-1
- ADP-ribosylation factor 1-like 2
- Aminopeptidase ltah-1.1
Sequence:
MSISGLFILDLKGNVVISRNYRGDVDMSCIEKFMPLLVEKEDEGSASPVLVHQGISYTYIKYMNVYLVTISKKNTNVILVLSALYKIVEVFCEYFKTLEEEAVRDNFVIIYELFDEMLDFGYPQTTESKILQEFITQQGNRLETVRPPMAVTNAVSWRSEGIKYRKNEVFLDVIESVNMLANAQGTVLRSEIVGSIRFRVVLSGMPELRLGLNDKVFFQQSGASSRRGNSGKGVELEDIKFHQCVRLSRFDSERTISFIPPDGEFELMSYRLTTQVKPLIWVEAAVERHAHSRVEYMVKAKSQFKRQSVANHVEVIIPVPSDVSAPKFKTGAGTAKYVPELNAIVWSIRSFPGGREYIMRSSFMLPSIGSEELEGRPPINVKFEIPYYTTSGLQVRYLKIIEKSGYQALPWVRYVTQNGDYQMRMT
Protein: Transcription factor Sp4 (Q62445)
Organism: Mus musculus (Mouse)
Function: Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Required for normal male reproductive behavior.
Subcellular location: Nucleus.
Interaction partners:
- Transmembrane protein 196
Sequence:
MSDQKKEEEEEAAAAMATEGGKTSEPENNNKKPKTSGSQDSHPSPLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPASSSSSSSSSNNGSSSPTKTKSGNPSTPNQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVTAGGGTGQVGQPTTTTDSGTSNGNQLVSTPTTSTAPASTMPESPSSSTTCTTTASTTLTSSDTLVSSADTGQYASTSASSSERTIEEPQTPAATESEAQSSSQLQSNGIQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDAEVQPGKRLRRVACSCPNCREGEGRGSSEPGKKKQHVCHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF
Protein: Rifin (Q8IIZ3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKIHYTNILLFPLKLNILVNTHKKPSITPRHIQTTRSLCECELYAPANYDSDPEMKRVMQQFHDRTSQRFHEYDDRMKTTRQKCKDKCDKEIQKIILKDKLEKQMAQQFSTLHTDIQSDAIPTCVCEKSLADKVEKGCLRCAQNLGGVAPGWGLLSGFGYVTWSQYISGIAAKAAADAGLKAGVKVGLVNAVKIVTNTLGSAGKVPTMDWEKLIIFGNFSDGVTLHAIFKNLNNVMNGHLDFGKYSEFSTVVQKFAEKFKPITAKYSTEIAEVTNAVADAKAGVLTKAGNATSSLSTGITASIIAIVVIVLIMVIIYLILRYRRKKKMKKKLHYIKLLEE
Protein: Dihydroxyacetone kinase 2 (DHA kinase 2) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase 2) (Triokinase 2) (Triose kinase 2) (O74215)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.
Interaction partners:
- Glycerol dehydrogenase 1
- Triosephosphate isomerase
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Fructose-bisphosphate aldolase
- Dihydroxyacetone kinase 1
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase [NAD
- Uncharacterized acyltransferase C1718.04
Sequence:
MSVKQFVSDGHIVRPYLLGLARSNPGLTVIEHDRVIYRTASAPGSGDLPKVTLVSGGGSGHEPTHAGFVGDGALDAVACGDIFASPSTKQIYSALKAVASPKGTLIIVKNYTGDIIHFGLAAERAKAAGMNVELVAVGDDVSVGKKRGALVGRRGLGATVLVHKIAGSAAALGLDLHQVAQVAQSVIDNAATIAASLDHCAVPGRKFETNLGPDEYEIGMGIHNEPGTFKSSPLPSIPELVTEMLSILFGEKNPDNSFVEFSSKDDVILLVNNMGGMSNLELGYATEVVSEQLAKRGIIPKRTMSGTFVTALNGPGFGITLVNASKATPDIFKYFDLPTTASGWNVSYHNAKDWEVLADGKVPTAPALEHTRNEKHSGVKADPKMFTKILKAAVDAINEFEPKTTWYDTIAGDGDCGTTLVNGGEAITKAINDKSIRLDDGVNGIDDLAYIVEDSMGGTSGGLYSIYLSALAKGVHESGDSELSVHTFAFASKYALDALFKYTRARKGFRTLIDAIQPFVETLNEGKGLDAAAKAATEGSEQTRKMDAVVGRASYVAKEELHKLDSEGGLPDPGAFALAAILNAIVEASEH
Protein: RILP-like protein 1 (Rab-interacting lysosomal-like protein 1) (Q9JJC6)
Organism: Mus musculus (Mouse)
Function: Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (By similarity). Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5EBL4}. Cell projection, cilium {ECO:0000269|PubMed:23264467}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23264467}.
Interaction partners:
- Ras-related protein Rab-10
- Ras-related protein Rab-8A
- Ras-related protein Rab-7L1
- EH domain-binding protein 1-like protein 1
- Protein phosphatase 1H
- Ras-related protein Rab-35
Sequence:
MEEPLGSPPAALSALEKNVAELTVMDVYDIASLVGHEFERVIDQHGCESIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDRLRVERMDRIEKERKHQKELELVEDVWRGEAQDLLSQIAQLQEENKQLMTNLNHKDVGFSEEEFQKQEGMSERERQVMKRLKEVVDKQRDELRAKDRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQTKEQEMGSLRAELGKLRERLQGEHSQNGEEEEAEIQPQPDGEESISDAEKAALDLKDPNRPRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEIEEENRIPQPPPITHPRTSPQPESGIKRLFSFFSRDKKRLANTQRPTHIHESFGQWAITQRDDGYTEQGQEALQHL
Protein: Oxysterol-binding protein 1 (P22059)
Organism: Homo sapiens (Human)
Function: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:24209621, ECO:0000269|PubMed:29514919}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24209621}. Golgi apparatus membrane; Peripheral membrane protein {ECO:0000269|PubMed:24209621}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000269|PubMed:24209621}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29514919}. Note=Predominantly cytosolic. {ECO:0000269|PubMed:24209621}.
Interaction partners:
- Vesicle-associated membrane protein-associated protein A
- Vesicle-associated membrane protein-associated protein B/C
- ADP-ribosylation factor 1
- Pleckstrin-2
- Pleckstrin
- Phosphatidylinositol 4-kinase beta
- Motile sperm domain-containing protein 2
- Golgi resident protein GCP60
- Sterol regulatory element-binding protein cleavage-activating protein
- Membrane-associated phosphatidylinositol transfer protein 1
Sequence:
MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGPGAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWSSCPDIF
Protein: Mitochondrial translation ATP-dependent RNA helicase mrh5 (EC 3.6.4.13) (O74356)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:34634819}.
Interaction partners:
- Ribosome production factor 2 homolog
- Mitochondrial translation factor sls1
- Uncharacterized protein C4F10.09c
- Brix domain-containing protein C1B9.03c
- Cytochrome b translation regulator cbp8
- ATP-dependent RNA helicase mss116, mitochondrial
- Cytochrome b translation regulator cbp7
- Small ribosomal subunit protein L51-b
- AdoMet-dependent rRNA methyltransferase spb1
- Pescadillo homolog
Sequence:
MKCCPASILDRFNAIKVINVMGLRLNGRSVPWLLQTRKFINITSPRYTAGRPVILNENQLIRYLPNYTNKGDEEVTRRKKLHEPNGPKFHELPLNQNILDGLSTNFAEYKNSTPLQQRIINALMKSGVSFIVRGWNGSGKSFGAMLSTLSMYFEALKFLKHNPVAGKPVQSGCQVLFIVPNDNLAAQYQFWIERLLHGITEKEELQHIYKILTLTPASLDSFQNRPPYIGITTFPNLQHCIKKNQPILKQFTSQLQLLIVDESDLVIPDHGRSRRLSSPEILADKIFLSSFIQLCKKNLRINMDDENVGGMGIHSQLHGKGSIPTMVFMSASNSKNGVNYLSRYITDQLGIIGIDRKHQWYWNLTSTPSVFHYLIKAQAEPKTTKVTLTNLPYEFVRFNNSMHSIGDNNFSYNNSEAVLQIFAQSVPRILNIEAKKSKLENNILKCVMIVLPKEFNPHSFCNQYKGFAVGNRFWQCRTLSTESLNFSTNLNNVVFVANPSEIRGLHLPSITHIFHLWSTFSGVAYQHIAGRLGAMGQTGKIFNFIIPDYYKSNDFKKTDFRRCILFMLQRVGIRPKSYEFDDEHF
Protein: D-inositol 3-phosphate glycosyltransferase (EC 2.4.1.250) (N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase) (GlcNAc-Ins-P N-acetylglucosaminyltransferase) (P9WMY7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the transfer of an N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol (MSH) biosynthesis pathway. MSH and WhiB3 are probably part of a regulatory circuit that mediates gene expression upon acid stress (like that found in host macrophage phagosomes). MSH is one of the major redox buffers which protects bacteria against redox stressors and antibiotics; loss of MSH or ergothioneine (ERG, the other major redox buffer in this bacteria) leads to respiratory alterations and bioenergetic deficiencies that negatively impact virulence.
Interaction partners:
- 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
- Mycothiol acetyltransferase
- L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
- Mycothiol S-conjugate amidase
- Uncharacterized protein Rv0487
- HTH-type transcriptional regulator EthR
- 1,4-alpha-glucan branching enzyme GlgB
- Phosphoheptose isomerase
- Malto-oligosyltrehalose trehalohydrolase
- Transcriptional regulator Rv0485
Sequence:
MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALLAVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPVVRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDIVHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTDDEARQVISLHGADPARIDVVHPGVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQPLKAPDIVLRAAAKLPGVRIIVAGGPSGSGLASPDGLVRLADELGISARVTFLPPQSHTDLATLFRAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSGHEVGQWADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGEYNAERQRRGGEVISDLVAVGKPRHWTPRRGVGA
Protein: Multidrug and toxin extrusion protein 1 (MATE-1) (mMATE-1) (Solute carrier family 47 member 1) (Q8K0H1)
Organism: Mus musculus (Mouse)
Function: Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (By similarity). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (By similarity). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16330770}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16641166}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver). {ECO:0000250|UniProtKB:Q96FL8}.
Interaction partners:
- Solute carrier family 22 member 2
- Solute carrier family 22 member 1
- Organic anion transporter 3
- Solute carrier organic anion transporter family member 4C1
- Solute carrier family 22 member 6
- Solute carrier family 22 member 3
Sequence:
MERTEESAPGPGGADAASERRGLRCLLLPGFLEELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWKRACQQAQVHANLKVNVALNSAVSHEPAHPVCPESHGEIMMTDLEKKDETQLDQPMNQQQALPIRPKDSNKLSGKQLALRRGLLLLGVVLVLVGGILVRVYIRIE
Protein: F-box protein VBF (Protein PHLOEM PROTEIN 2-LIKE B14) (AtPP2-B14) (VIP1-binding F-box protein) (Q9C7K0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(VBF) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins such as VIP1 and Agrobacterium virE2, after their implication in T-DNA translocation to the host nucleus (can functionally replace Agrobacterium VirF). Required during Agrobacterium-induced tumor formation.
Interaction partners:
- Transcription factor VIP1
- Plant-specific TFIIB-related protein 1
- Acyl-CoA N-acyltransferases
- RNI-like superfamily protein
- SKP1-like protein 1A
- Importin subunit alpha-7
- Importin subunit alpha-8
- Importin subunit alpha-4
- Importin subunit alpha-5
- Importin subunit alpha-6
Sequence:
MMMLPEACIANILAFTSPADAFSSSEVSSVFRLAGDSDFVWEKFLPSDYKSLISQSTDHHWNISSKKEIYRCLCDSLLIDNARKLFKINKFSGKISYVLSARDISITHSDHASYWSWSNVSDSRFSESAELIITDRLEIEGKIQTRVLSANTRYGAYLIVKVTKGAYGLDLVPAETSIKSKNGQISKSATYLCCLDEKKQQMKRLFYGNREERMAMTVEAVGGDGKRREPKCRDDGWMEIELGEFETREGEDDEVNMTLTEVKGYQLKGGILIDGIEVRPKT
Protein: MB2r protein (P70239)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MAALWLLLLVLSLHCMGAGGFVAHVESTCVLDDAGTPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISMILNEQESLIQRLQNGLQDCATHTQPFWDVLTHRTRAPSVRVAQTAPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH
Protein: Chaperone CupA2 (Q9I1Y6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
Interaction partners:
- Usher CupA3
- Fimbrial subunit CupA1
- Usher CupC3
- Fimbrial subunit CupA4
- Usher CupB3
- PapC-like C-terminal domain-containing protein
- Chaperone CupA5
- EAL domain-containing protein
- Probable fimbrial subunit CupB1
- Fimbrial-type adhesion domain-containing protein
Sequence:
MPRHSYRSGRTSALLLVLLASIAQARASVVVTGTRVIYPGEAREKTVQLSNRDAFPNVVQAWVDIDAPDAPPDQADAPFLVNPAVFRMAPDSGQTLRIVYTGQGLPGDRESLFHLNVLQIPPRNSSHADRNQMLLMLRNRLKLFYRPAGIQGRPEDLPGQLRFALVRRSAGWAVRVDNPSGYYASFASATLSVGQRRWRLRSGMLEPRSHAEWQAETREALPPGRVRLHALLINDYGAHMDIRHDLSP
Protein: MORN repeat-containing protein 4 (Protein 44050) (Retinophilin) (Q8NDC4)
Organism: Homo sapiens (Human)
Function: Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25822849}. Cell projection, filopodium tip {ECO:0000269|PubMed:25822849}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q6PGF2}. Note=Found in the cytoplasm in the absence of MYO3A and localizes at filopodial tips in the presence of MYO3A. {ECO:0000269|PubMed:25822849}.
Interaction partners:
- Myosin-IIIa
- Myosin-IIIb
- Hyaluronan mediated motility receptor
Sequence:
MTLTKGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTFEGEFKNGRVDGFGLLTFPDGSHGIPRNEGLFENNKLLRREKCSAIVQRAQSASKSARNLTA
Protein: Lipid transferase CIDEB (Cell death activator CIDE-B) (Cell death-inducing DFFA-like effector B) (O70303)
Organism: Mus musculus (Mouse)
Function: Activates apoptosis.
Subcellular location: Lipid droplet {ECO:0000269|PubMed:19187774, ECO:0000269|PubMed:26733203}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19187774, ECO:0000269|PubMed:23297397}; Peripheral membrane protein {ECO:0000269|PubMed:19187774}; Cytoplasmic side {ECO:0000269|PubMed:19187774}. Golgi apparatus {ECO:0000269|PubMed:23297397}. Cytoplasmic vesicle, COPI-coated vesicle {ECO:0000269|PubMed:23297397, ECO:0000269|PubMed:30858281}. Note=Enriched at lipid droplet contact sites. {ECO:0000269|PubMed:26733203}.
Interaction partners:
- Apolipoprotein B-100
Sequence:
MEYLSAFNPNGLLRSVSTVSSELSRRVWNSAPPPQRPFRVCDHKRTVRKGLTAASLQELLDKVLETLLLRGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLEQGQSWSPKSGMLSYGLGREKPKHSKDIARITFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGVGPKRVLRELLRWTSSLLQGLGHMLLGISSTLRHVVEGADRWQWHGQRHLHS