wanglab/gogpt-training-data huggingface dataset:
Protein: Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (Cyclophilin G) (Matrin cyclophilin) (Matrin-cyp) (Rotamase G) (O55035)
Organism: Rattus norvegicus (Rat)
Function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.
Subcellular location: Nucleus matrix {ECO:0000269|PubMed:9525923}. Nucleus speckle {ECO:0000269|PubMed:9525923}. Note=Colocalizes with splicing factors at nuclear speckles. {ECO:0000269|PubMed:9525923}.
Interaction partners:
- Peptidylprolyl isomerase domain and WD repeat-containing protein 1
- CWC25 spliceosome-associated protein homolog
- Pre-mRNA-splicing factor SYF2
- Cell division cycle 40.
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
- Peptidyl-prolyl cis-trans isomerase
- Splicing factor YJU2
- Serine/arginine repetitive matrix protein 1
- Serine/arginine repetitive matrix 2
- Pre-mRNA-splicing factor CWC22 homolog
Sequence:
MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELVPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSDSSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEADNVDAQPQSTVRPEEIPPIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRFGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKIEKEKKVKDHKSESKERDIRRNSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKQLDSKGKDQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRSRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRDSRSSEREESQSRNKEKYRSQDSKSSHRKENSEGEKRMYSKSRDHSSSNNNREKKADIDQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHESSPGTDEDKSG
Protein: Vacuolar iron transporter 1 (AtVIT1) (Q9ZUA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Vacuolar iron transporter involved in the transfer of iron ions from the cytosol to the vacuole for intracellular iron storage. Involved in regulation of cellular iron homeostasis. Vacuolar iron storage is required for seed embryo and seedling development (Probable).
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:17082420}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Metal transporter Nramp3
- Metal transporter Nramp4
- Vacuolar iron transporter homolog 1
- Cation-chloride cotransporter 1
- Vacuolar iron transporter homolog 3
- Putative metal tolerance protein C3
- Metal transporter Nramp1
- Fe
- Ferric reduction oxidase 2
- Metal tolerance protein 1
Sequence:
MSSEEDKITRISIEPEKQTLLDHHTEKHFTAGEIVRDIIIGVSDGLTVPFALAAGLSGANASSSIVLTAGIAEVAAGAISMGLGGYLAAKSEEDHYAREMKREQEEIVAVPETEAAEVAEILAQYGIEPHEYSPVVNALRKNPQAWLDFMMRFELGLEKPDPKRALQSAFTIAIAYVLGGFIPLLPYMLIPHAMDAVVASVVITLFALFIFGYAKGHFTGSKPLRSAFETAFIGAIASAAAFCLAKVVQH
Protein: Moesin a (Membrane-organizing extension spike protein) (Moesin 1) (Q66I42)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000269|PubMed:20736288}; Peripheral membrane protein {ECO:0000305}. Cell junction {ECO:0000269|PubMed:20736288}.
Interaction partners:
- Actin alpha 1, skeletal muscle b.
- Na
- Ezrin
- Sodium/hydrogen exchanger
- CD44 antigen
- Actin, cytoplasmic 2
- Actin, cytoplasmic 1
- Protein kinase C
- Protein kinase C
- PATJ crumbs cell polarity complex component.
Sequence:
MPKTISVRVTTMDAELEFAIQPSTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQEATQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQAKYADYNKDAHTPGYLSNEKLLPQRVLEQHKLNKEQWEERIQVWHEEHKGMLREDSMMEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDKMTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAQRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAKEEKNHKKMERALLEDERKKREQAEKEKEKIEKEKEELMERLRVIEEQTRKAQQELEEQTRKALELEQERKRAQEEAERLERERRLAEEAKSALLQQSESQMKNQEHLATELAELTSKISLLEDAKKKKEDEALEWQTKATMVQEDLEKTKEELKNKVMSSHVTEPVHGENDNDEGDESSAEASAELTSAAAYKDRSEEERMTEAEKNERVQKHLLALTSELANARDETKKTQNDIIHAENVRAGRDKYKTLRQIRSGNTKQRIDEFECM
Protein: Zinc finger protein 474 (Testis-specific zinc finger protein) (TSZFP) (Q6S9Z5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MERGKKKRISNKLQQTFHHSKEPTFLINQAGLLSSDSYSSLSPETESVNPGENIKTDTQKKRPGTVILSKLSSRRIISESQLSPPVIPARRPGFRVCYICGREFGSQSIAIHEPQCLQKWHIENSKLPKHLRRPEPSKPQSLSSSGSYSLQATNEAAFQSAQAQLLPCESCGRTFLPDHLLVHHRSCKPKGEGPRAPHSNSSDHLTGLKKACSGTPARPRTVICYICGKEFGTLSLPIHEPKCLEKWKMENDRLPVELHQPLPQKPQPLPNAQSSQAGPNQAQLVFCPHCSRIFTSDRLLVHQRSCKTHPYGPKYQNLNLGSKGGLKEYTNSKQQRNRAAPSVTDKVIHATQDALGEPGGALCL
Protein: Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (A0A2R8Q0U9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Matrix metallopeptidase 9.
- Matrix metallopeptidase 24
- Matrix metallopeptidase 11a.
- Hemopexin b.
Sequence:
MMMMMMMKMCTRECVTAGLLFFMCVCLNQQMLEACSCASAHPQQLFCSADAVLRAEITGEKIRRREDINPMYGLGKIQYEVQVIKVFKGSDRIKDLQHVYTHEMSSMCGIRLNRGQYLLSGSMMSEGFFVTLCDFVEHWDRLSLTQKKNLKYRYQMGCNCTISICTEQPCHPKVKNECILTDWSSLWPFEDGEPVHEYACIRHSDGSCSWHEGGTSVPSEKNTTDISEG
Protein: Extracellular sulfatase Sulf-1 isoform X1 (Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-)) (Sulfatase 1) (Sulfatase FP1c) (Q6EFA1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell surface {ECO:0000256|ARBA:ARBA00004241}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus, Golgi stack {ECO:0000256|ARBA:ARBA00004348}.
Interaction partners:
- Heparan-sulfate 6-O-sulfotransferase 2
Sequence:
MMQLVSLAWMMVLAAPLVCFGFTTRGQGLRGRVQGDRRNIRPNIILIMTDDQDVELGSLQVMNKTRKIMEDGGTSFTNAFVTTPMCCPSRSSMLTGKYVHNHNTYTNNENCSSPSWQAQHEPRSFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWVGLIKNSRFYNYTVCRNGNKEKHGADYAKDYFTDLITNDSINYFRTSKRMFPHRPVMMVISHAAPHGPEDSAPQYSELFPNASQHITPSYNYAPNMDKHWIMQYTGPMKPIHMEFTNYLHRKRLQTLMSVDDSVEKVYNALVDTGELDNTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFVRGPNVEPGARNNHVVLNIDLAPTILDIAGLDTPPDMDGKSILKLLEQEKTGNRFKPNRKPKVWRDTFLVERGKILRKKEDSASSLNTQHSNSLPKYKKVKEVCQQAEFQTPCEQPGQKWHCVEEVSGKWRLQKCKGSLKEGSKKRTRSLRSRSYDNREKDCHCGERPYKAAKAARRAHRQFGQSSNPRYRPRFVHTRPARSLSVEFEGEIYDVDLQADDKTPLEPRPISKRHYEPEPGFDSDFGLESDDGSEEMQSDDTNAVGYPNSLKVTHKCFILINDTVRCEREIYQSSRAWKDHKNFVDHEIEQLQDKMKKLREVRGHLKRRRPDECDCSKKSYFSKEREQKNKPERLKNRNDHLHPFKEAMQEVDSKAQLYNEIRRRKKERKVRKRQKKGDDCSLPGLTCFTHNNDHWQTAPFWNLGGFCACTSSNNNTYWCLRTVNETHNTLFCEFATGFLEYFDLNSDPYQLTNAVYTVEKDILSQLHSQLMEMRSCQGHKQCNPRPRSSDAEHSQPGTSTKVKLPNFTEDVDWQGLADLYSMNESLYEHRHNYSPVLDDWMNFWKDVDSMFALLRNLKTLNQTDKLDPLVELGSGVLEEASGAGSLILENLATAGPSVDLTPRTFQESHLKSLNELPEGRPTKVSPLPRGDTWVHQLENELGDDGLTFSGNGVTELETRHDFVLRSSKMLDLHQQEEEEDIFQAQGYLPVSPQPEPAEETPPAQSDRPQERWNFSIKSFTHKPRDIQDSEGSASGLSH
Protein: Seipin (Few lipid droplets protein 1) (Q06058)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size. Facilitates initiation of LD formation, and ensures that vectorial budding of LDs from the ER is directed towards the cytoplasm.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18093937, ECO:0000269|PubMed:18250201}; Multi-pass membrane protein {ECO:0000269|PubMed:18093937, ECO:0000269|PubMed:18250201}. Note=Concentrates at endoplasmic reticulum lipid droplet junctions. {ECO:0000269|PubMed:18093937}.
Interaction partners:
- Protein LDB16
- Lipid droplet organization protein LDO45
- Acyl-coenzyme A diphosphatase YFT2
- Protein PET10
- Diacylglycerol O-acyltransferase 1
- Peroxisomal membrane protein PEX30
- Lipid droplet organization protein LDO16
- Acyl-coenzyme A diphosphatase SCS3
- Phospholipid:diacylglycerol acyltransferase
- Mitochondrial protein import protein MAS5
Sequence:
MKINVSRPLQFLQWSSYIVVAFLIQLLIILPLSILIYHDFYLRLLPADSSNVVPLNTFNILNGVQFGTKFFQSIKSIPVGTDLPQTIDNGLSQLIPMRDNMEYKLDLNLQLYCQSKTDHLNLDNLLIDVYRGPGPLLGAPGGSNSKDEKIFHTSRPIVCLALTDSMSPQEIEQLGPSRLDVYDEEWLNTIRIEDKISLESSYETISVFLKTEIAQRNLIIHPESGIKFRMNFEQGLRNLMLRKRFLSYIIGISIFHCIICVLFFITGCTAFIFVRKGQEKSKKHS
Protein: NADPH--hemoprotein reductase (EC 1.6.2.4) (Q384I1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Anamorsin homolog
- Homocysteine S-methyltransferase, putative
Sequence:
METKAIMLLVVSAIGVVMLTWLFVSICTRKSKDDDMHNEPLLSKHANSKLMEVDGRVLVLYGSQTGTAEMFARNLTREGSRRGFPLKVLDIEKYQASNLVKEKRVIIVCATYGDGEPTDPMVEFHDWLMSDSRVMGEELSGVRYTVFGLGDRQYVNFCREGITVDRRMSELGAQRFYPLGRGDYSDDIEEDFDKWRSGLWPALSTELALDVKSGEEGPVAPECCMKALESSDEAPLPFPKADPGLEPTQRLPSWAPVKVNKELLSNATGRSTRLIEFDTSETVISYQAGDHLGVLPSNPSEMVNTYLRVLGVSEQESSQVISLENKNTGECVFPCRASIRTALTWYIDLAGPPKKSTLRAFAHYCTDPVEKDTLLKLLSTEPESVEAYGKLVLELRTVLGFLQRFKSMSPPLSFFLEMMPRIAPRYFSISSDSLTHPTSVAITVAVVEGGLCTNLLQQAAVGQNIPVFVRKSNFHLPLQAEDRPIIMIGPGTGVAPFIGFLHRRSAWLEKGNKVGDALLFFGCRRREEDHIYADFMEKCLSNGALSVRDVAYSREQADKVYVQHRLAARGKEVWEIISRGGNVYVCGDAKNMARDVERQLLDIAQKYGAMKEDEATALLEKLATDERYLKDVWTA
Protein: Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1) (Q9HD47)
Organism: Homo sapiens (Human)
Function: May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes.
Subcellular location: Nucleus {ECO:0000269|PubMed:11290418}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21447824}. Cytoplasm {ECO:0000269|PubMed:11290418, ECO:0000269|PubMed:21447824}. Cell membrane {ECO:0000269|PubMed:21447824}; Peripheral membrane protein {ECO:0000305|PubMed:21447824}; Cytoplasmic side {ECO:0000305|PubMed:21447824}. Note=May shuttle between the nucleus and cytoplasm. {ECO:0000269|PubMed:11290418}.
Interaction partners:
- GTP-binding nuclear protein Ran
- Ran-specific GTPase-activating protein
- Sodium channel protein type 5 subunit alpha
- Adhesion G-protein coupled receptor D1
- Glycerol-3-phosphate dehydrogenase 1-like protein
- Sodium channel regulatory subunit beta-3
- Potassium voltage-gated channel subfamily E member 3
- Sarcolemmal membrane-associated protein
- Sodium channel regulatory subunit beta-2
- Sodium channel regulatory subunit beta-1
Sequence:
MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDPNIFGPQ
Protein: ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) (Q3S1M2)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Vacuole membrane {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004128}.
Interaction partners:
Sequence:
MFPLVRELVCGSDYELLETGWRNNSNIPQVTNCGQHTDFSTIPTLFLVIFSPILFYELYKSRNSYLRSFSAISLRIIFCCLLVVDLTATVIYDFYLLFTKSPLYNAIHFYGDLVQYAGFCLALVLTIACRNRGIITSGVITLYWLLVVVCGVPELRYYITGRLYKEYEIHSCRAALYVFAYVCSALELFLSCFADTPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYRRKIKKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAKEIALSGNGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDMDVVDERLPDNIGDFLLTFSELVACVVFTSYATPFAIFPIVLIAIGCFAILRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEGNNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSMAKDANVV
Protein: Phosphatase 1 nuclear targeting subunit, isoform A (Phosphatase 1 nuclear targeting subunit, isoform B) (SD07532p) (Q9VPU9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
Interaction partners:
Sequence:
MPRIVPLQLLRCLRVLLDNNGGILSAVEVKRISGLMAKYSKKLVSKCVYVQILKSTKTELLGDFMAVGGWSLVYTWLNDAIRAMNWPLVQEILELLLLSPVDVNRLKINSAPILVKGLCKDGGNEGVRILAKRLVEQWLKIVTENTSMTIQGAAPHIAATTASQVPASVSGAGSASVPDSASSSDSTDSAGAPVTYTITSAANSSNSNSITIKWKPLLDNPDGGDETDSGTQSKDNEVEHLEKGSSATHLLADASLGKKSGLDDSSSAAEVKSGEDVDNKKHKSSKSDKSKRSEKEREKDRKKESSSHRSSSSSHKSSSSSSSSSSKSSSSKSSSSSSSSHRSSSDKYRDKDKARSSSGSSSSSKDRERSSGSSSSSSNKHKSSKSSSSSSSSSSSSSGSSSSKDRKSSSSTSSSSSSSRQDKDKDNKLMPPPAVAASNAAGTSPTASAKESDAQKPRSIPIMSRKASISIEIRRDTEKTATVKTYQSKFRSHGLTEEAPPPPSRKGLKKPTSSAVAASPALMAVPSSLKRPSPPPRDLSTDKKAKIDINNVAGHVERPGAAKLIAPKKSKQQMLESLLMLFSILFHSPRTLVAFAFVFDRSRMSNSAVLFVDLHSILKVFNFAWGGS
Protein: Protein ripply1 (Q2WG80)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites.
Subcellular location: Nucleus {ECO:0000269|PubMed:16326386}.
Interaction partners:
- Mesoderm posterior ba.
- T-box transcription factor TBX6
- Hairy and enhancer of split-related-7.
- Transducin-like enhancer protein 3-A
- Hairy-related 1.
- Mesoderm posterior ab.
- Mesoderm posterior bb
Sequence:
MNSVCFATPHTKHMDSKMQLTSSPASLWRPWLVTRKDAQTECRRTKLACPYSRPEVPGNTTTDGKMQSFQHPVRLYWPRSKSFDYLFSDGEALLRNFPVQATINFYDESDSEDEEESCDEDDESDVEDCLKHNSHFTAFN
Protein: Kelch domain containing 2 (G3V2H2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSYGTQLVPAMKEK
Protein: Envelope glycoprotein O (F5HGP1)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays a role in viral entry into host cells. Forms a trimeric complex at the surface of the viral envelope together with gH and gL. This complex is required for entry in host fibroblasts. Mechanistically, engages host receptor(s) including PDGFRA to mediate infection.
Subcellular location: Virion membrane {ECO:0000305}. Note=Host membrane associated, either via its interaction with gH, or as a type II transmembrane protein. {ECO:0000305}.
Interaction partners:
Sequence:
MGKKEMIMVKGIPKIMLLISITFLLLSLINCNVLVNSRGTRRSWPYTVLSYRGKEILKKQKEDILKRLMSTSSDGYRFLMYPSQQKFHAIVISMDKFPQDYILAGPIRNDSITHMWFDFYSTQLRKPAKYVYSEYNHTAHKITLRPPPCGTVPSMNCLSEMLNVSKRNDTGEKGCGNFTTFNPMFFNVPRWNTKLYIGSNKVNVDSQTIYFLGLTALLLRYAQRNCTRSFYLVNAMSRNLFRVPKYINGTKLKNTMRKLKRKQALVKEQPQKKNKKSQSTTTPYLSYTTSTAFNVTTNVTYSATAAVTRVATSTTGYRPDSNFMKSIMATQLRDLATWVYTTLRYRNEPFCKPDRNRTAVSEFMKNTHVLIRNETPYTIYGTLDMSSLYYNETMSVENETASDNNETTPTSPSTRFQRTFIDPLWDYLDSLLFLDKIRNFSLQLPAYGNLTPPEHRRAANLSTLNSLWWWSQ
Protein: Neutral ceramidase 2 (AtNCER2) (N-CDase 2) (NCDase 2) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (N-acylsphingosine amidohydrolase 2) (Q304B9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9VA70}. Endoplasmic reticulum {ECO:0000250|UniProtKB:F4HQM3}. Golgi apparatus {ECO:0000250|UniProtKB:Q0JL46}.
Interaction partners:
- Ceramide kinase
- Non-lysosomal glucosylceramidase
- Alkaline ceramidase
- Non-lysosomal glucosylceramidase
- Non-lysosomal glucosylceramidase
- Non-lysosomal glucosylceramidase
- Sphingosine kinase 2
- Sphingosine kinase 1
- Sphinganine C4-monooxygenase 2
- Sphinganine C4-monooxygenase 1
Sequence:
MAVSLPLFQFILFLLLLLLSRTVYAYLIGVGSYDITGPAADVNMMGYANSDQIASGIHFRLRARAFIVAEPQGNRVVFVNLDACMASQIVTIKVLERLKARYGELYTEKNVAISGIHTHAGPGGYLQYVTYIVTSLGFVRQSFDVVVNGIEQSIVQAHESLRPGSAFVNKGDLLDAGVNRSPSSYLNNPAAERSKYKYDVDKEMTLVKFVDSQLGPTGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWFENGQKNSVSSRNIPRRVSTIVSDFSRNRDRLLDIAATYKSSRGHSVDKSLDVKTRVRNGSKRKFVSAFCQSNCGDVSPNTLGTFCIDTGLPCDFNHSTCNGQNELCYGRGPGYPDEFESTRIIGEKQFKMAVELFNKATEKLQGKIGYQHAYLDFSNLDVTVPKAGGGSETVKTCPAAMGFGFAAGTTDGPGAFDFKQGDDQGNVFWRLVRNVLRTPGPEQVQCQKPKPILLDTGEMKEPYDWAPSILPIQILRIGQLVILSVPGEFTTMAGRRLRDAIKSFLISSDPKEFSNNMHVVIAGLTNTYSQYIATFEEYEVQRYEGASTLYGRHTLTAYIQEFKKLATALVNGLTLPRGPQPPDLLDKQISLLSPVVVDSTPLGVKFGDVKADVPPKSTFRRGQQVNATFWSGCPRNDLMTEGSFAVVETLREGGKWAPVYDDDDFSLKFKWSRPAKLSSESQATIEWRVPESAVAGVYRIRHYGASKSLFGSISSFSGSSSAFVVV
Protein: Clock-controlled pheromone ccg-4 [Cleaved into: Pheromone ccg-4] (Q01301)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function: Pheromone that is regulated by the circadian clock. Expression is mating type specific and under the control of the mating type locus. Involved in conidiation.
Subcellular location: Secreted {ECO:0000269|PubMed:12139624}.
Interaction partners:
- FHA domain-containing protein
- Hyphal anastamosis protein 2
- Pheromone receptor
- Striatin Pro11
- Pheromone receptor pre-1
Sequence:
MKFTLPLVIFAAVASATPVAQPNAEAEAQWCRIHGQSCWKVKRVADAFANAIQGMGGLPPRDESGHQPAQVAKRQVDELAGIIALTQEDVNAYYDSLSLQEKFAPSTEEEKKTEKVAKREAEAEAQWCRIHGQSCWKKREAEAQWCRIHGQSCWKRDALPEAEPQWCRIHGQSCWKKRDAAPEAAPEAEANPQWCRIHGQSCWKAKRAAEAVMTAIQSAEAESALLLRDTTFSPVDRVGKRDPQVCNMRLHPKKVCWKRDASPEAACNAPDGSCTKATRDLHAMYNVARAILTAHSDEN
Protein: Fatty acyl-CoA reductase 6, chloroplastic (AtFAR6) (EC 1.2.1.84) (B9TSP7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the reduction of fatty acyl-CoA and -ACP (acyl carrier protein) substrates to fatty alcohols. Triggers the accumulation of C16 and, to a lower extent, of C18 fatty alcohols; converts palmitoyl-acyl carrier protein to the corresponding C16:0 alcohol with NAD(P)H as electron donor. Triggers also the formation of some C16:0 and C18:0 aldehydes. May be involved in the generation of C30 primary alcohol.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:22166367}.
Interaction partners:
- Wax ester synthase/diacylglycerol acyltransferase 1
- Wax ester synthase/diacylglycerol acyltransferase 9
- Protein CER1-like 2
- Protein CER1-like 1
- Very-long-chain 3-oxoacyl-CoA reductase 1
- Very-long-chain aldehyde decarbonylase CER1
Sequence:
MATTNVLATSHAFKLNGVSYFSSFPRKPNHYMPRRRLSHTTRRVQTSCFYGETSFEAVTSLVTPKTETSRNSDGIGIVRFLEGKSYLVTGATGFLAKVLIEKLLRESLEIGKIFLLMRSKDQESANKRLYDEIISSDLFKLLKQMHGSSYEAFMKRKLIPVIGDIEEDNLGIKSEIANMISEEIDVIISCGGRTTFDDRYDSALSVNALGPGRLLSFGKGCRKLKLFLHFSTAYVTGKREGTVLETPLCIGENITSDLNIKSELKLASEAVRKFRGREEIKKLKELGFERAQHYGWENSYTFTKAIGEAVIHSKRGNLPVVIIRPSIIESSYNEPFPGWIQGTRMADPIILAYAKGQISDFWADPQSLMDIIPVDMVANAAIAAMAKHGCGVPEFKVYNLTSSSHVNPMRAGKLIDLSHQHLCDFPLEETVIDLEHMKIHSSLEGFTSALSNTIIKQERVIDNEGGGLSTKGKRKLNYFVSLAKTYEPYTFFQARFDNTNTTSLIQEMSMEEKKTFGFDIKGIDWEHYIVNVHLPGLKKEFLSKKKTE
Protein: Proclotting enzyme (EC 3.4.21.86) [Cleaved into: Proclotting enzyme light chain; Proclotting enzyme heavy chain] (P21902)
Organism: Tachypleus tridentatus (Japanese horseshoe crab)
Function: This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system in limulus. Its active form catalyzes the conversion of coagulogen to insoluble coagulin gel.
Subcellular location: Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:2266134}. Secreted {ECO:0000269|PubMed:2266134}. Note=Secreted in hemolymph probably upon bacterial lipopolysaccharide (LPS) stimulation. {ECO:0000303|PubMed:2266134}.
Interaction partners:
Sequence:
MLVNNVFSLLCFPLLMSVVRCSTLSRQRRQFVFPDEEELCSNRFTEEGTCKNVLDCRILLQKNDYNLLKESICGFEGITPKVCCPKSSHVISSTQAPPETTTTERPPKQIPPNLPEVCGIHNTTTTRIIGGREAPIGAWPWMTAVYIKQGGIRSVQCGGALVTNRHVITASHCVVNSAGTDVMPADVFSVRLGEHNLYSTDDDSNPIDFAVTSVKHHEHFVLATYLNDIAILTLNDTVTFTDRIRPICLPYRKLRYDDLAMRKPFITGWGTTAFNGPSSAVLREVQLPIWEHEACRQAYEKDLNITNVYMCAGFADGGKDACQGDSGGPMMLPVKTGEFYLIGIVSFGKKCALPGFPGVYTKVTEFLDWIAEHMV
Protein: Zinc finger protein SNAI3 (Protein snail homolog 3) (Zinc finger protein 293) (Q3KNW1)
Organism: Homo sapiens (Human)
Function: Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MPRSFLVKTHSSHRVPNYRRLETQREINGACSACGGLVVPLLPRDKEAPSVPGDLPQPWDRSSAVACISLPLLPRIEEALGASGLDALEVSEVDPRASRAAIVPLKDSLNHLNLPPLLVLPTRWSPTLGPDRHGAPEKLLGAERMPRAPGGFECFHCHKPYHTLAGLARHRQLHCHLQVGRVFTCKYCDKEYTSLGALKMHIRTHTLPCTCKICGKAFSRPWLLQGHVRTHTGEKPYACSHCSRAFADRSNLRAHLQTHSDAKKYRCRRCTKTFSRMSLLARHEESGCCPGP
Protein: SD04906p (Q960E5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHFFLEDFLQAHLPKIYDKMQSCNKNSSSRITTTNNNVTTTSNISGNSSNKRCPQKYTGNTLAVNSNMLAYQQQATAGGKNSTRKSRHNNNKQNHQQQQQQQQQQFDHIHKRNGTAGGTGSECSPAAPTSNWLQRGYGRQFVHSSCIEDKLLGHHNPGHRNSTSSDATSEDIDSSSELPNKSKGNSCAGSIHASGGSKSRSKRHQKQSGQQTRNPDHNGQRTGAATPCTNQKAKQGNAKWRQQQPNPSSNNQQQQMQQQKRGRNKKPGKWSNNIIDNPNSNHGGSSQQKTCDSSSSSALSSPTSSATTSATSSPTNSPTSYPRANGNRKRIEAALEWRREQELGRQNANFLVPPLRQYEQLEFDDKTVVQQLRRHIIDNHLLRVYGFPVDSVVHEGAIEIFKCMPHMSFAAALAETAQAVTVINYHDGLTNRAEEEVANSTDSGNSSPQSLDSESGGEWSGSECESSNSSSSSAGEAALGLELKYCHFVPVERSLSKPCARCKRHFLVDELTGQYLTHEECQYHSGKYQRYYDGVSHGRWTCCNEGEESSPGCCLGDRHVWSGSVVGVNGPYYDFVRTEHRGSGEDEPAVYALDCEMSYTGRGLDVTKVSLVALNGQLVYEHFVRPVCDIIDYNTQYSGITETDLCSGAKSLAEVQRDLLQLITADTILIGHGLENDLRALRLVHNTLIDTSISFPHCNGFPYRRALRHLTKVHLKRDIQAGDGTTGHSSFEDSRACMELMLWRVNRELDPAWSWDD
Protein: ADP ribosylation factor (Eurofung) (Q5B360)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Uncharacterized protein
- Rho GTPase activator Rga
- VHS domain protein
- ADP-ribosylation factor
- SH3 domain protein
- Zinc finger protein gcs1
- Uncharacterized protein
Sequence:
MGGSVSKIMGKIFGTKEMRILMLGLDAAGKTTILYKLKLTNQDVTTIPTVGFNVESVTYKNVKFNVWDVGGQDKIRPLWRHYYSGTQGLIFVVDSSDTARMDEARSELHKIINDREMKDALLLVFANKQDVPGHLSPDEVISALKLHSLKDKTWYVAPSVATEGTGIFEGLAWLSNNVKVQQPQK
Protein: Importin subunit alpha (Q9U1H6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSASHKQRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQAADMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSERENEQLEATQKFRKLLSRDPNPPIEEVIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKISHGLPILARLLKYTDADVQSDTCWAIGYLSDGPNDNIQAVIDAGVCRRLVELLIHPQQNVSTAALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINEHIPQLMVIMQTAEFKTRKEAAWAITNATSSGTDEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNALENILKAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEEDSRVAPVAGTQQFEFDPDNMPSTGFNF
Protein: Testis-specific expressed protein 55 (Testis-specific conserved, cAMP-dependent type II PK-anchoring protein) (Q96M34)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:A6X8Z9}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:31429579}.
Interaction partners:
Sequence:
MEEPPQEALAEPLKHESPAAPSSAGHTKGQEEDDQKNQAERKADNHTAHRIADQTALRVPSQAESSIFSQATNGVAEQNGHSTPGQAGRRASNPADVSDLRADDQVNQTPSEQTKGKASSQANNVQHEQSDGQVSGLTEERTAEQTERRLPTQAERRTSGQIDGRLAMPSDQRGSRQTDHRMAGQSERRASEQMDRRMSGEAERRTSEQITHRLSKLSERRPSVQIDSGSSVPSDQSPSVQIDSGSSVPSDQRPSVQIDRRMSGKVRRRSSEKTDYRLAGLADPGTSEQTDLRLYGLVDHKTSVKTHHQVYGQATELAEHQAIDQAHSNADQPPVDNAHYTESDQTDHLADRQANHKDQLSYYETRGQSEDRIFPQLGNSKEDKEADYRVQPCKFEDSQVDLNSKPSVEMETQNATTIPPYNPVDARFTSNFQAKDQALFPRLPSISSKLNYTSSQEKTQAIVTKSDEFSEIDQGKGYHIRNQTYRRFPSIVYEDPYQVSLQYMEKHHILQIFQQITENLVYEKPEDPLNFMLCQV