wanglab/gogpt-training-data huggingface dataset:
Protein: Ethanolamine ammonia-lyase reactivase EutA (P76551)
Organism: Escherichia coli (strain K12)
Function: Reactivates suicidally inhibited ethanolamine ammonia-lyase (EAL), cyanocobalamin-inactivated EAL and O(2)-inactivated EAL; requires Mg(2+), ATP and adenosylcobalamin. Reactivation probably occurs by the ATP-dependent exchange of cobalamin.
Subcellular location: Bacterial microcompartment {ECO:0000305}.
Interaction partners:
- Ethanolamine ammonia-lyase large subunit
- Ethanolamine ammonia-lyase small subunit
- Probable ethanolamine permease EutH
- Acetate kinase EutQ
- Probable acetate kinase EutP
- Bacterial microcompartment shell protein EutS
- Ethanolamine utilization protein EutJ
- Corrinoid adenosyltransferase EutT
- Bacterial microcompartment shell protein EutL
- Bacterial microcompartment shell vertex protein EutN
Sequence:
MNTRQLLSVGIDIGTTTTQVIFSRLELVNRAAVSQVPRYEFIKREISWQSPVFFTPVDKQGGLKEAELKTLILEQYHAAGIEPESVDSGAIIITGESAKTRNARPAVMALSQSLGDFVVASAGPHLESVIAGHGAGAQTLSEQRLCRVLNIDIGGGTANYALFDAGKISGTACLNVGGRLLETDSHGRVVYAHKPGQMIVDECFGAGTDARSLTGAQLVQVTRRMAELIVEVIDGTLSPLAQALMQTGLLPAGVTPEIITLSGGVGECYRHQPADPFCFADIGPLLATALHDHPRLREMNVQFPAQTVRATVIGAGAHTLSLSGSTIWLEGVQLPLRNLPVAIPIDETDLVGAWQQALIQLDLDPKTDAYVLALPASLPVRYAAVLTVINALVDFVARFPNPHPLLVVAGQDFGKALGMLLRPQLQQLPLAVIDEVIVRAGDYIDIGTPLFGGSVVPVTVKSLAFPS
Protein: Transcription factor EB (B1AKB2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQMPNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIE
Protein: MD-2-related lipid-recognition protein 3 (Q9FF98)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in herbivory-mediated responses. May play a role in herbivory-associated molecular pattern (HAMP) recognition. May function is jasmonate (JA) signaling in response to HAMP. May play a role in defense response against the pathogens Altenaria brassicicola and Pseudomonas syringae.
Subcellular location: Vacuole {ECO:0000269|PubMed:23903439}. Endoplasmic reticulum {ECO:0000269|PubMed:23903439}. Note=Localized in endoplasmic reticulum bodies (ER bodies). {ECO:0000269|PubMed:23903439}.
Interaction partners:
- Membrane protein of ER body 1
- PYK10-binding protein 2
- TSA1-like protein
- Inactive GDSL esterase/lipase-like protein 23
- Inactive GDSL esterase/lipase-like protein 25
- Beta-glucosidase 23
- Transcription factor NAI1
- Jacalin-related lectin 22
- Membrane protein of ER body 2
- Prostaglandin E synthase 2
Sequence:
MAMSHVQPMLLLLVSLFFLPALRGAIDFEYCAKNGNDYGTVTSIVVSPSVGPHENPTITINLFGSASKNIPAGTLVYVAFRDGEFTGLLKTYNLCDVSACNNEAEIEAGTNFELTLSDVLYVGYDEEIKYSVSLRRKTLEEEDPIIKMCVDFKVPAPAPAFVSI
Protein: Probable trafficking protein particle complex subunit 2 (O02173)
Organism: Caenorhabditis elegans
Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi. Required for the systemic spread of the RNAi response.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}.
Interaction partners:
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 3 homolog
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 8
- Trafficking protein particle complex subunit 9
- Trafficking protein particle complex subunit 10
- Trafficking protein particle complex subunit 11 domain-containing protein
Sequence:
MATKEFYFAIIGHCDQPIFEMDFPVGEKKTKESEGTRHLNHYIGHAALDIVDEHALTTSQMYLKMVDKFNEWYVSAFVTASRIRFIMLHTHRADEGIKQFFQEMYETYIKHAMNPFYEIDDVIESPAFEQKATLYGRKYLS
Protein: Oligopeptide transport ATP-binding protein OppD (EC 7.4.2.6) (P9WQJ5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:38548954}. Note=Attached to the internal side of the transmembrane subunits OppB and OppC. {ECO:0000269|PubMed:38548954}.
Interaction partners:
- Oligopeptide transport system permease protein OppC
- Oligopeptide transport system permease protein OppB
- Oligopeptide-binding protein OppA
- Probable dipeptide-transport integral membrane protein ABC transporter DppC
- Probable dipeptide-transport ATP-binding protein ABC transporter DppD
- Uncharacterized lipoprotein Rv2585c
- Probable dipeptide-transport integral membrane protein ABC transporter DppB
Sequence:
MSPLLEVTDLAVTFRTDGDPVTAVRGISYRVEPGEVVAMVGESGSGKSAAAMAVVGLLPEYAQVRGSVRLQGTELLGLADNAMSRFRGKAIGTVFQDPMSALTPVYTVGDQIAEAIEVHQPRVGKKAARRRAVELLDLVGISQPQRRSRAFPHELSGGERQRVVIAIAIANDPDLLICDEPTTALDVTVQAQILDVLKAARDVTGAGVLIITHDLGVVAEFADRALVMYAGRVVESAGVNDLYRDRRMPYTVGLLGSVPRLDAAQGTRLVPIPGAPPSLAGLAPGCPFAPRCPLVIDECLTAEPELLDVATDHRAACIRTELVTGRSAADIYRVKTEARPAALGDASVVVRVRHLVKTYRLAKGVVLRRAIGEVRAVDGISLELRQGRTLGIVGESGSGKSTTLHEILELAAPQSGSIEVLGTDVATLGTAERRSLRRDIQVVFQDPVASLDPRLPVFDLIAEPLQANGFGKNETHARVAELLDIVGLRHGDASRYPAEFSGGQKQRIGIARALALQPKILALDEPVSALDVSIQAGIINLLLDLQEQFGLSYLFVSHDLSVVKHLAHQVAVMLAGTVVEQGDSEEVFGNPKHEYTRRLLGAVPQPDPARRG
Protein: LIM/homeobox protein LMX-1.2 (Homeobox protein LMX-1) (LIM/homeobox protein 1) (LMX) (P53413)
Organism: Gallus gallus (Chicken)
Function: Specifies dorsal cell fate during limb development.
Subcellular location: Nucleus.
Interaction partners:
- Paired-box containing protein Pax-2
- T-cell leukemia homeobox protein 3
- NK2 homeobox 2
- Forkhead box A2
- Sonic hedgehog protein
- Fibroblast growth factor 8
- Protein Wnt
Sequence:
MDIASGPESLERCFPRGPTDCAKMLDGIKMEDHPLRSGPATLGVLLGSECPHQAVCEGCQRPISDRFLMRVNESSWHEECLQCAVCQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLSCFCCCVCERQLRKGDEFVLKEGQLLCKSDYEKEKDLLSSVSPDDSDSVKSDDEDGDVKPTKGQVTQGKGSDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVMSNRMEGMMTSYTPLAPPQQQIVAMDQSSYGTDPFQQGLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFLASSEVNSMQARVGNPIDRLYSMQSSYFAS
Protein: Signaling pathway modulator ZraP (Zinc resistance-associated protein) (Q9L9I0)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Binds zinc. Could be an important component of the zinc-balancing mechanism (By similarity).
Subcellular location: Periplasm {ECO:0000250|UniProtKB:P0AAA9}.
Interaction partners:
- Sensor histidine kinase ZraS
- Transcriptional regulatory protein ZraR
- P-type Zn
Sequence:
MKRNNKSAIALIALSLLALSSGAAFAGHHWGNNDGMWQQGGSPLTTEQQATAQKIYDDYYTQTSALRQQLISKRYEYNALLTASSPDTAKINAVAKEMESLGQKLDEQRVKRDVAMAQAGIPRGAGMGYGGCGGYGGGYHRGGGHMGMGNW
Protein: Trafficking protein particle complex subunit (Q9VSY8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus, cis-Golgi network {ECO:0000256|ARBA:ARBA00004222, ECO:0000256|PIRNR:PIRNR018293}.
Interaction partners:
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex subunit
- FI18195p1
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit
- Probable trafficking protein particle complex subunit 2
- Trafficking protein particle complex subunit 10
- Trafficking protein particle complex subunit 11
- Protein brunelleschi
Sequence:
MSRQASRLDAKKVNSEFLTLTYGALVTQMLRDFENAEDVNKQLERIGYNMGMRLIEDFLARTSAPRCLEMRETADRIQQAFRIYLNIQPTISNWSPASDEFSLVFDSNPLTEFVELPPDLTNLRYSAILSGCIRGALEMVQLEVQCWFVQDQLKGDNVTELRVKFVRRLEEVIPAGED
Protein: Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (CEK-7) (EPH homology kinase 1) (EHK-1) (Q60629)
Organism: Mus musculus (Mouse)
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P54757}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P54757}. Cell projection, dendrite {ECO:0000250|UniProtKB:P54756}.
Interaction partners:
- Ephrin-A5
- Ephrin-A2
- Tyrosine-protein kinase ABL1
- Ephrin-A1
- Ephrin-A3
- Ephrin-A4
- Ephexin-1
- Ras GTPase-activating protein 1
- Sterile alpha motif domain-containing protein 5
- Ephrin-B2
Sequence:
MRGSGPRGAGHRRTQGRGGGDDTPRVPASLAGCYSAPLKGPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDENGRSIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAIFPDTITGADSSQLLEVSGSCVNHSVTDDPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVSVAASNDQSQIPIIAVSVTVGVILLAVMIGFLLSGSCCDCGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNMLDKLIRNPSSLKTLVNASSRVSTLLAEHGSLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMSSLQEMKVQMVNGMVPV
Protein: Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] (Q6AY09)
Organism: Rattus norvegicus (Rat)
Function: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P55795}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein A1
- Serine/arginine-rich splicing factor 2
- Heterogeneous nuclear ribonucleoprotein C
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Heterogeneous nuclear ribonucleoprotein A3
- Heterogeneous nuclear ribonucleoprotein U
- Serine/arginine-rich splicing factor 3
- Polypyrimidine tract-binding protein 1
- RNA binding protein fox-1 homolog 2
- Serine/arginine-rich splicing factor 7
Sequence:
MMLSTEGREGFVVKVRGLPWSCSAEEVMRFFSDCKIQNGTSGVRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMTMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYGGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSSFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVEFATHEDAVAAMAKDKANMQHRYVELFLNSTAGTSGGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSAGYGGGYGGQSSMSGYDQVLQENSSDYQSNLA
Protein: Protein archease (Protein ZBTB8OS) (Zinc finger and BTB domain-containing opposite strand protein 8) (Q8IWT0)
Organism: Homo sapiens (Human)
Function: Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.
Interaction partners:
- RNA-splicing ligase RtcB homolog
- ATP-dependent RNA helicase DDX1
- Protein FAM98B
- RNA transcription, translation and transport factor protein
- Ashwin
- Eukaryotic peptide chain release factor subunit 1
Sequence:
MAQEEEDVRDYNLTEEQKAIKAKYPPVNRKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFFIPREVKVLSIDQRNFKLRSIGWGEEFSLSKHPQGTEVKAITYSAMQVYNEENPEVFVIIDI
Protein: Glutathione S-transferase (EC 2.5.1.18) (A0A384P5E9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDFEKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK
Protein: DNA repair protein RAD51 homolog (A0A8I5YC80)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364139}.
Interaction partners:
Sequence:
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGYHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQVSCWGSASVRMDVKGTSSRIPYVYGLSGSDVLDNVAYARGFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
Protein: Intracellular growth locus protein B (A0Q7I4)
Organism: Francisella tularensis subsp. novicida (strain U112)
Interaction partners:
Sequence:
MTINKLSLTDELLNNFGGSTEVDSVLKNIDFDVSDDASKVLSLSTDYNARNLMALSLVLANNDNINNYNQKYIQKVITVIDKLIDLQVNSIISNDEFRALEQEWLKVQEVCQEDYDNVEVSILDVKKEELQYDFERNLYDISSSDFFKKVYVSEFDQYGGEPYGAILGLYNFENTTNDIIWLTGMGMVAKNSHAPFIASIDKSFFGVKDLSEITHIKSFEALLEHPRYKEWNDFRNLDVAAYIGLTVGDFMLRQPYNPENNPVQYKLMEGFNEFVDYDKNESYLWGPASIHLVKNMMRSYDKTRWFQYIRGVESGGYVKNLVACVYDNKGILETKSPLNVLFADYMELSLANIGLIPFVSEKGTSNACFFSVNSAKKVEEFVDGFDSANSRLIANLSYTMCISRISHYIKCVIRDKIGSIVDVESIQKILSDWISEFVTTVYQPTPLEMARYPFRNVSIEVKTIPGKPGWYSCKINVIPHIQFEGMNTTMTIDTRLEPELFGTNNN
Protein: At5g47440 (Auxin canalization protein (DUF828)) (Q9FGL4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEGGFYSDWNDSSSSLFGSENPEHELEEGNVRSEEIVSQIPQPQTPREPMKFLSRSWSLSASEISKALAQKQRQQRDLFSVSQNSPRGFFQDVAADPLMAENIMNSAGTRRSGRLSKWFHHKQHTNPSTMRIPRKKDKARVQKAHVHSAVSIAALAAGLASVTSEESCSKESCSMMALALASATELLASHCIDMAEQAGADHTCVASTVRSSVDIHSPGDLMTLTAAAATALRGEAALKVRQPKESRKNATITPCERSFSDSHWPGENCQFRLEEPNLPLEGELVQCARNGLQRNKRVCVYINKKSQVMIKLKSKHVGGAFSKKIKCVVYGVCDEISAWPCRKERENSEEVYFGLKTGQGLLEFKCKSKIQKQRWVAGIQSNLRLVSCLEAAKCSLESLSLSNRMR
Protein: Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta-like protein (P0C2Y2)
Organism: Oryza sativa (Rice)
Subcellular location: Plastid, chloroplast stroma {ECO:0000305}.
Interaction partners:
Sequence:
MALQSLRGSMRSVVGKRICPLIEYAIFPPLPRIIVYASRRARMQRGNYSLIKKPKKVSTLRQYQSTKSPMYQSLQRICGVREWLNKYCMWKEVDEKDFGFEIGAFD
Protein: Beta-defensin 104 (Beta-defensin 4) (BD-4) (DEFB-4) (hBD-4) (Defensin, beta 104) (Q8WTQ1)
Organism: Homo sapiens (Human)
Function: Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.
Subcellular location: Secreted.
Interaction partners:
- Beta-defensin 103
- Beta-defensin 105
- Beta-defensin 1
- Defensin beta 4A
- Beta-defensin 106
- Beta-defensin 107
- Beta-defensin 108B
- Neutrophil defensin 1
- Sperm associated antigen 11B
- Defensin alpha 5
Sequence:
MQRLVLLLAISLLLYQDLPVRSEFELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (O53347)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- DNA 3'-5' helicase
- ATP-dependent DNA helicase UvrD2
- ATP-dependent DNA helicase UvrD1
- Conserved ala-, pro-rich protein
- Possible transmembrane cation transporter
- Protein RecA
- DNA polymerase I
- 5'-3' exonuclease
- Replicative DNA helicase DnaB
- NAD-capped RNA hydrolase NudC
Sequence:
MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVIAGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRLARLAGIGLGCGDPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDTRLLSETELWQLAFDVVSGYDGVLCTDKSPAAVTSIVVRLWGQLGEHLVDTRALRDTHVELERLVHALPAGRYQRDRGPSQWLLRMLATQTQRAELVPLLDALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLDEYQDTGHAQRVVLSSLFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTTDFPLSDGTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRALRPRPDAPPGAVRCALLPDVQAEREWIADHLRMRYQRAEADGVKPPTAAVLVRRNADAAAIADTLRARGIPAEVVGLAGLLSIPEVAEVVAMLRLVADPTAGAAAMRVLTGPRWRLGARDLAALWRRALTLSGESPSTASPESIAMAASADADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSALRGRLGHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAERASARSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVHAAKGLEWQVVAVAHLSRGVFPSTVSRSSWLTDPAELPPLLRGDRASAGAHGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERRLLYVAVTRAEDTLLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWASAPAGDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSADLPGSTTDIDHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGDPVGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADREVGDPEELAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAVFVDPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVYRLAWAALRGCPTSSVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT
Protein: Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (Estrogen sulfotransferase) (ST1E3) (Sulfotransferase, estrogen-preferring) (P49887)
Organism: Cavia porcellus (Guinea pig)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesteroland xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:1406700, ECO:0000269|PubMed:7980593}.
Interaction partners:
- Estradiol 17-beta-dehydrogenase
- Cytochrome P450 1A1
- Hydroxysteroid 17-beta dehydrogenase 2
- Aromatase
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- UDP-glucuronosyltransferase
- (3R)-3-hydroxyacyl-CoA dehydrogenase (17-beta-hydroxysteroid dehydrogenase 8) (Estradiol 17-beta-dehydrogenase 8) (Testosterone 17-beta-dehydrogenase 8)
- Cytochrome P450 1A2
- Very-long-chain 3-oxoacyl-CoA reductase
- glucuronosyltransferase
Sequence:
MMDSSEHDYYEYFDEFRGILLYKQFIKYWDNVEAFQARPDDLVIAAYPKSGTTWISEVVCMIYAEGDVKKCRQDAIFNRVPFLECRNDKMMNGVKQLEEMNSPRIIKTHLPPRLLPASFWEKRCKMICICRNAKDVAVSYYYFFLMVANHPDPGSFPEFVEKFMQGQVPYGSWYDHVKSWWEKSTDPRILFIFYEDMKEDIRKEVLKLIHFLGRKPSEELVDKIIKHTSFQEMKNNPSTNYTMLPEEIMNQKVSPFMRKGISGDWKNHFTVALNESFDKHYQQQMKGSTLQLRTEI
Protein: Kinesin-like protein KIF3C (O35066)
Organism: Mus musculus (Mouse)
Function: Microtubule-based anterograde translocator for membranous organelles.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Kinesin-associated protein 3
- Kinesin-like protein KIF3A
- Kinesin light chain 2
Sequence:
MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQARAVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNAAGGPATQPTAGGGSGSGSASGSASSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKKGMLGKRPRRKSSRRKKAVSAPAGYPEGSVIEAWVAEEEDDNNNNHHPPQPILEAALEKNMENYLQDQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTYSSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLFLDCEEEQWRFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVSPPAIFEMEFSHDQEQDPRVLHMERLMRLDSFLERPSTTKVRKSRSWCQSPQRMPPPSTAHASMTSVPLHPATVVDHD
Protein: Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) (Protein ESP2) (Q07141)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Transcription factor 7 like 2
- Lymphoid enhancer-binding factor 1
- Transcription factor 7 like 2
- TLE family member 1, transcriptional corepressor
- Transducin-like enhancer protein 3
- Catenin beta-1
- LIM domain binding 1
- Transcription factor 7
- Transcription factor 4
- Transcription factor 7 like 1
Sequence:
MIRDLSKMYRRRAHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPCLSQEQQQLQAQHLLTWTWSACASDTTPLGFSQPFHPSGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGSEKHRNSTDYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASVASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDITDPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVRPGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
Protein: Inositol diphosphatase DSP3 (EC 3.6.1.52) (Inositol pyrophosphate phosphatase DSP3) (Protein PLANT AND FUNGI ATYPICAL DUAL-SPECIFICITY PHOSPHATASE 3) (AtPFA-DSP3) (Q681Z2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Possesses phosphotyrosine phosphatase activity in vitro. Hydrolyzes para-nitrophenyl phosphate in vitro. Hydrolyzes O-methylfluorescein phosphate in vitro. Dephosphorylates the phosphoinositides PI(3,5)P2.
Subcellular location: Nucleus {ECO:0000269|PubMed:24901469}.
Interaction partners:
- Dual specificity protein phosphatase PHS1
- Photosystem I reaction center subunit III, chloroplastic
- Photosystem I reaction center subunit VIII
- Photosystem I reaction center subunit psaK, chloroplastic
- Photosystem I reaction center subunit V, chloroplastic
- acid phosphatase
- Photosystem I reaction center subunit IX
- Photosystem I subunit O
- FCS-Like Zinc finger 1
- Photosystem I chlorophyll a/b-binding protein 5, chloroplastic
Sequence:
MCLIMETDDHNGDVLAPPSNFSMVEDGIYRSGFPRPENFSFLKTLNLRSIIYLCPEPYPEENLKFLEANNIKLYQFGIEGKTDPPTPMPKDTVLDALKVLVDVRNHPILIHCKRGKHRTGCLVGCLRKVQSWCLSSVLEEYQKNAGLKWRQRDLNFIEAFDIVSLRQCLLSIMYQYHGYGFKRRRLAYEEENVKTPKPQAARV