wanglab/gogpt-training-data huggingface dataset:
Protein: G2/mitotic-specific cyclin-1 (P24868)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
Interaction partners:
- Mitosis inhibitor protein kinase SWE1
- G2/mitotic-specific cyclin-2
- Cell cycle serine/threonine-protein kinase CDC5/MSD2
- Cyclin-dependent kinase 1
- Protein SIC1
- Meiosis-specific APC/C activator protein AMA1
- Transcriptional factor SWI5
- G1/S-specific cyclin CLN3
- APC/C activator protein CDC20
- M-phase inducer phosphatase
Sequence:
MSRSLLVENSRTINSNEEKGVNESQYILQKRNVPRTILGNVTNNANILQEISMNRKIGMKNFSKLNNFFPLKDDVSRADDFTSSFNDSRQGVKQEVLNNKENIPEYGYSEQEKQQCSNDDSFHTNSTALSCNRLIYSENKSISTQMEWQKKIMREDSKKKRPISTLVEQDDQKKFKLHELTTEEEVLEEYEWDDLDEEDCDDPLMVSEEVNDIFDYLHHLEIITLPNKANLYKHKNIKQNRDILVNWIIKIHNKFGLLPETLYLAINIMDRFLCEEVVQLNRLQLVGTSCLFIASKYEEIYSPSIKHFAYETDGACSVEDIKEGERFILEKLDFQISFANPMNFLRRISKADDYDIQSRTLAKFLMEISIVDFKFIGILPSLCASAAMFLSRKMLGKGTWDGNLIHYSGGYTKAKLYPVCQLLMDYLVGSTIHDEFLKKYQSRRFLKASIISIEWALKVRKNGYDIMTLHE
Protein: Receptor-like serine/threonine-protein kinase NCRK (EC 2.7.11.1) (Q8VYY5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:18088316}; Single-pass type I membrane protein {ECO:0000269|PubMed:18088316}. Prevacuolar compartment membrane {ECO:0000269|PubMed:18088316}. Endosome {ECO:0000269|PubMed:18088316}.
Interaction partners:
- Uncharacterized protein
- Protein disulfide-isomerase 5-1
- Ras-related protein RABF2a
- CRIB domain-containing protein RIC2
- Protein trichome birefringence-like 34
- Probable galacturonosyltransferase 10
- Probable calcium-binding protein CML1
- Putative disease resistance protein At1g50180
- Rac-like GTP-binding protein ARAC5
Sequence:
MKMRVETALAILLVLISIQQCYGGVSNYTCTCFSSGNRSDILESNCSTSCNCRPDRDQWVCLCPANGFPVIAIGGSNSSCFTSCNCSAGATKSSKKQYLSRKLVIVILLFCGVLISLAFLASMICYICRKDKFSGQTPSVSSDRESSWHSSANLINRKSSVSQSKISISSSVAGCFFQNASLFCVSKPETIHGAIFQFSYTELEQATNKFSSNSVIGHGGSSCVYRGQLKDGKTAAIKRLNTPKGDDTDTLFSTEVELLSRLHHYHVVPLIGYCSEFHGKHAERLLVFEYMSYGSLRDCLDGELGEKMTWNIRISVALGAARGLEYLHEAAAPRILHRDVKSTNILLDENWHAKITDLGMAKCLSSDGLQSGSSSPTTGLQGTFGYFAPEYAIAGCASQMSDVFSFGVVLLELITGRKPIQKPSNNKGEESLVIWAVPRLQDSKRVIEELPDPRLNGKFAEEEMQIMAYLAKECLLLDPESRPTMREVVQILSTITPDTSSRRRNFPINYLFQSNEKKKESKVGWSRGGSKSGQEEETVDLTEPRFESFCLPNVKPVLLEPSAHI
Protein: Cyclin D21 (F4IJJ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAENLACGETSESWIIDNDDDDINYGGGFTNEIDYNHQLFAKDDNFGGNGSIPMMGSSSSSLSEDRIKEMLVREIEFCPGTDYVKRLLSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKDWAAQLLAVSCLSLASKMEETDVPHIVDLQVEDPKFVFEAKTIKRMELLVVTTLNWRLQALTPFSFIDYFVDKISGHVSENLIYRSSRFILNTTKAIEFLDFRPSEIAAAAAVSVSISGETECIDEEKALSSLIYVKQQERVKRCLNLMRSLTGEENVRGTSLSQEQARVAVRAVPASPVGVLEATCLSYRSEERTVESCTNSSQSSPDNNNNNNNSNKRRRKQ
Protein: Inhibitor of Bruton tyrosine kinase (IBtk) (Q9P2D0)
Organism: Homo sapiens (Human)
Function: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
Interaction partners:
- Tyrosine-protein kinase BTK
- Cullin-3
- Eukaryotic initiation factor 4A-I
Sequence:
MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
Protein: VQ motif-containing protein 18 (AtVQ18) (O64868)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as positive regulator of plant growth.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9M9F0}.
Interaction partners:
- VQ motif-containing protein 29
- VQ motif-containing protein 8, chloroplastic
- Protein HAIKU1
- VQ motif-containing protein 20
- VQ motif-containing protein 22
- VQ motif-containing protein 9
- Calmodulin-binding protein 25
- Sigma factor binding protein 2, chloroplastic
- Sigma factor binding protein 1, chloroplastic
- VQ motif-containing protein 10
Sequence:
MEITQYQSFHEGSSSRVSMNRNSQVISKIKPKIRIIHIFAPEVIKTDVKNFRSLVQSLTGKPAPGEAKTGKKRAKSRITTPQEPVCDDHQPVNRLSGFTGLLANGGNHQVKEEWGSGDQSTSNTNTYFDLEGLIQDVGEDYFSSFPMRSSSSSQVEGFIFNNNNNNNNNNNNNNNNNTNFDTKAHNSS
Protein: 40S ribosomal protein S15, putative (Q57XN7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 60S ribosomal protein L7a
- Elongation factor 2
- 60S ribosomal protein L18a
- 60S ribosomal protein L27, putative
- Bystin, putative
- 60S ribosomal protein L4
- Ribosomal protein S19, putative
- Elongation factor TU, putative
- Pretranslocation protein, alpha subunit, putative
- Large ribosomal subunit protein uL5
Sequence:
MASNITQERYEQLKKERTFHKFTYRGHEIDPLLALTEEEFKALVHARARRRMNRHADRRAPVLLKRLREAKKNVKAGEKPKAVKTHLRDVVITPEMVGSVVGIYNGRQFNAVEIKGEMIGHYLGEFSLTYKPVAHGRPGFGATHSSRFIPLK
Protein: Ammonia transport outward protein 2 (P32907)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transporter protein required for ammonia export. Involved in acetate resistance.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17395151}; Multi-pass membrane protein {ECO:0000269|PubMed:17395151}. Note=Localizes to large detergent resistant patches of the cell membrane (DRM) enriched in ergosterol and sphingolipids.
Interaction partners:
Sequence:
MSDREQSSGNTAFENPKALDSSEGEFISENNDQSRHSQESICKIYTAGKNNEYIYIGRQKFLRDDLFEAFGGTLNPGLAPAPVHKFANPAPLGLSGFALTTFVLSMFNARAQGITIPNVVVGCAMFYGGLVQLIAGIWEIALENTFGGTALCSFGGFWLSFGAIYIPWFGILDAYKDKESDLGNALGFYLLGWALFTFGLSVCTMKSTIMFFALFFLLAVTFLLLSIANFTGEVGVTRAGGVLGVIVAFIAWYNAYAGIATRQNSYIMVHPFALPSNDKVFF
Protein: Nephronectin a (B8A5G4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Integrin, alpha 8
- Uncharacterized protein.
- FRAS1-related extracellular matrix 2b
- FRAS1-related extracellular matrix 2a
- Fras1-related extracellular matrix 1a.
- Fras1-related extracellular matrix 1b.
- Integrin beta
- Integrin beta
- Integrin beta
- Integrin beta
Sequence:
MWIIKFMLMWTCWIAVDADFDGRWSRQMSSSNGLCRYGGRIDCCWGWTRVSWGQCQPLYVLTRRVIGIRCQPQALCQHGCKHGECVGPNKCKCHPGYTGKTCNQDLNECGLKPRPCKHRCMNTFGSFKCYCLNGFMLLPDGSCANARTCSMANCQYGCEVMKGEVRCQCPSPGLQLAPDGRTCVDVDECAAGLAVCPRFRKCINTFGSYICKCHDGFDLQYVNGKYQCTDVNECSLGQHQCGPYATCYNTPGSYKCKCKEDYRGVGYDCKPIPKVVIDPPRPGKTTPSSNNNKGGNKIPGSDQKRTTTTVRPPVTAKRISPTITTTTTTTKPPPTKKITPPARVPVTTTRKPFIPTRKPPVLVTTKPKVPTHQHTTTKVPVVTAVVPFIPTRRPFTIPFVTPIDNSIKDITQKQRGDVHIPRNHGKNNVLGIDLDIELGNTEEELKDDPESGYLSCSFDHGLCGWIQRREGDLHWETSEDPSGGRYLTISEGGEKRGGRGAQLILPLKTPWNEGNLCLAFRHNMAGHHVGMLQVFVQKGRQHSPAVWGRTGGNGWRSTQITLWGNGLESVIVKGERRRGRKGEIALDDMSLKRGSCQEEHNLRRL
Protein: Chalcone synthase (EC 2.3.1.74) (Naringenin-chalcone synthase) (Q9FUB7)
Organism: Hypericum androsaemum (Tutsan)
Function: The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which undergoes enzyme-catalyzed or spontaneous isomerization into naringenin.
Interaction partners:
Sequence:
MVTVEEVRKAQRAEGPATVMAIGTAVPPNCVDQATYPDYYFRITNSEHKAELKEKFQRMCDKSQIKKRYMYLNEEVLKENPNMCAYMAPSLDARQDIVVVEVPKLGKEAAVKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPTDTHLDSLVGQALFGDGAAAIIIGSDPIPEVEKPLFELVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNVEKSLTEAFKPLGISDWNSLFWIAHPGGPAILDQVEAKLSLKPEKLRATRHVLSEYGNMSSACVLFILDEMRRKSKEDGLKTTGEGIEWGVLFGFGPGLTVETVVLHSVAIN
Protein: Fcgbp protein (Q8K0P6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
VDVTLPSSYHGAVCGLCGNMDKNHQNDQVFPNGTMAPSIPTWGGSWQVPGWDPLCWHECQGSCPTCPEDRVEEYEGPGFCGPLAPGTGSPFTSCHAHVPPESFFKGCVLDVCLGGGSKDILCQALAAYAAACQAAGIKIEDWRTQAGCEITCPDNSHYELCGPPCPASCPPPARHTAPTVCDGPCVEGCQCDEGFVLSADQCVPLDGGCGCWVNGTYYEAGTEFWADTTCSKRCHCGPGGDSLVCKPASCGLGEECALLPSGEIGCQPTSITECQAWGDPHYTTLDGHRFDFQGTCEYLLSAPCHEPPTGTEYFNVTVANEHRGSQAVSYTRSVTLQIYGLSLTLSAQWPRKLQVNGEFVALPFHLDQKLSVYISGADVVVNTASGVSLAFDGDSFVRLRVPAAYAGTLCGLCGNYNKNPKDDLTAVGGKPEGWKVGGAPGCDQCEPEPCPKPCTPEEQEPFRGPDACGIITAPEGPLAPCHSLVPPTQYFEACLLDACQVQGHPGGLCPAIATYVAACQAAGAQLGEWRKPDFCPLQCPAHSHYQLCGDSCPVSCPSLSAPVGCETICREGCVCDAGFVLSGDTCVPVGQCGCLYQGRYYVLGATFYPGPECERLCECGPDGQVTCQEGADCEPYEECRIENGVQACHPTGCGHCLANGGLHYVTLDGRVYDLHGSCSYVLASVCHPKPGDEEFSIVLEKNSAGDPQRVVVTVAGQVVGLARGPQVTVDGEVVTLPVATGHVSVTAEGRNIVLQTNKGMKVLFDGDAHILMSIPSSFRGRLCGLCGNFNGNWSDDFVLPSGAVAPNVEAFGTAWRAPGSSLGCGEGCGPQGCPVCLAEETQAYEKNDACGKIRDPHGPFAACHKVLSPLEYFRQCVYDMCAHKGDKAYLCRSLAAYTAACQAAGAAVKPWRTDSVCPLQCPAHSHYSICTRSCQGSCAALSGLTGCTTRCFEGCECDDHFLLSHGVCIPAQDCGCVHNGQYMPVNSSLMSSDCSERCFCSPNNGLTCHEAGCPSGHVCEIQAGVRECQAARGLCSISVGANLTTFDGAHNAISSPGVYELSSRCPGLQKNVPWYRVLADVQPCHNNDKIVSKVHIFFQDGLVTVIPSKGAWVNGLRVDLPATVLTSVSVRRMPDGSMLVHQKAGVTVWLGKDGLLDVMVGDDLAAMLCGACGNFDGDQTNDAYGSQGKTPIEKWRAQDFSPCSN
Protein: Uncharacterized protein C15orf32 (Q32M92)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNKRTSVDASKEDLHPADPQSGEGVPPNRKNTKTSPRGEGTAPPFSARPCVWTLCEMLSILALVGVLHPFYRSNNQVYQKLKTHLRCQSSRVDGLMLKPTLLTPSQLKSPEGHLILPTFNHLVIRHILDPKQIFCVADVCTDCKFNCGSIERHQKRHLMRVSQDWEHLIRYRNQICLS
Protein: Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol pentamannoside mannosyltransferase (EC 2.4.1.-) (Alpha-mannosyltransferase) (Alpha-ManT) (PPM-dependent mannosyltransferase) (Polyprenol-phosphate-mannose alpha-mannosyltransferase) (PPM alpha-mannosyltransferase) (A0R2K8)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Catalyzes the alpha-1,2 addition of a mannose residue from polyprenol-phosphate-mannose (PPM) to a monoacyl phosphatidylinositol pentamannoside (AcPIM5) to generate a monoacyl phosphatidylinositol hexamannoside (AcPIM6).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16803893}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in the plasma membrane-cell wall (PM-CW) fraction. {ECO:0000269|PubMed:16803893}.
Interaction partners:
- GDP-mannose-dependent alpha-
- GDP-mannose-dependent alpha-mannosyltransferase
- Alpha-
- Probable exported protein
- Alpha-
- Transmembrane protein
- Integral membrane protein
- Probable conserved transmembrane protein rich in alanine
Sequence:
MRVNGYRGAKVGAVDTTSPPEVPASARLQRLAPMLLVVSILARLAWTYLVPNGANFVDLHVYVGGADALDGPGALYDYVYADQTPDFPLPFTYPPFAAIVFYPLHLLPFGVVAFIWQIGIIAALYGVVRVSQRLMGLQSQRRVAMLWTALGIWTEPLRSTFDYGQVNVVLVLAVLCAVSTTRWWLSGLLVGLAAGIKLTPAVAGLYFLGARRWAAVACSAAVFFATVGVSWLVVGAQARRYFTELLGDADRIGPIGTSFNQSWRGGISRILGHDAGFGPLVLIGIGITAVLALLAWRAIGGAQDRLGGILVVSLFGLVLSPISWTHHWVWLIPLMMWLLHGPLSALRGARILGWGWLALTLLGVPWLLSFAQPTIWEIGRPWYLAWAGLVYIVATLATLGWIAFSRKGSG
Protein: Uncharacterized protein (Q6Z7U5)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAESHANVRVLAPRRPRQLLRMVVALQCLGLTVLHLNVTTTADHLALYSFSLKMEDECRLSSVDEIAGAVNQMVTKIAGECIS
Protein: Leucine-rich repeat and coiled-coil domain-containing protein 1 (Centrosomal leucine-rich repeat and coiled-coil domain-containing protein) (Q9C099)
Organism: Homo sapiens (Human)
Function: Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18728398}. Note=Associates with the centrosome throughout the cell cycle and extensively accumulates during the mitotic phase.
Interaction partners:
Sequence:
MEAAAAVVAAEAEVENEDGDSSCGDVCFMDKGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFLTNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM
Protein: Heat shock 70 kDa protein (P27541)
Organism: Brugia malayi (Filarial nematode worm)
Interaction partners:
- Stress-induced-phosphoprotein 1
- BMA-DNJ-12
- Heat shock protein 90
- DnaJ homolog subfamily B member 13
- DnaJ homolog subfamily B member 9
- BMA-DNJ-14
- Bm5434.
- DnaJ homolog subfamily C member 10
- GrpE protein homolog
- BMA-DNJ-24
Sequence:
MSKNAIGIDLGTTYSCVGVFMHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTVFDANRLIGRKFDDGSVQSDMKHWPFKVVNAGGGKPKVQVEYKGETKTFTPEEISSMVLVKMKETAEAFLGHAVKDAVITVPAYFNDSQRQATKDSGAIAGLNVLRIINEPTAAAIAYGLDKKGHGERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGEDFDNRMVNHFVAEFKRNDKKDLASNPRALRRLRTACERAKRTLSSSSQASIEIDSLFEGIDFYTNITRARFEELCADLFRSTMDPVEKALRDAKMDKAQVHDIVLVGGSTRIPKVQKLLSDFFSGKELNKSINPDEAVAYGAAVQAAILSGDKSEAVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKTSETFTTYSDNQPGVLIQVYEGERALTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSAQDKSTGKQNKITITNDKGRLSKDEIERMVQEAEKYKADDEAQKDRIAAKNALESYAFNMKQTIEDEKLKDKISEEDKKKIQEKCDETVRWLDGNQTAEKDEFEHRQKELESVCNPIITKLYQSAGGMPGGMPGGMPGGAPGAGSTGGGPTIEEVD
Protein: High affinity copper uptake protein 1 (Copper transporter 1) (CTR1) (Solute carrier family 31 member 1) [Cleaved into: Truncated CTR1 form] (Q8K211)
Organism: Mus musculus (Mouse)
Function: High-affinity, saturable copper transporter involved in dietary copper uptake.
Subcellular location: Cell membrane {ECO:0000269|PubMed:31002737}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:O15431}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:24167251}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16950140, ECO:0000269|PubMed:20699218, ECO:0000269|PubMed:31002737}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:24167251}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:19144690}; Multi-pass membrane protein {ECO:0000255}. Note=The localization is controlled by the intra and extra-cellular copper concentration. Under conditions of elevated extracellular copper concentrations, it is rapidly internalized by endocytosis from the plasma membrane by a clathrin- and dynamin-mediated process and degradated in order to prevent intracellular copper accumulation and to reduce the transport of the copper across the membrane. The internalized SLC31A1 is then localized in early endosomes, and, upon a low extracellular copper concentrations, it is transported back to the plasma membrane in a RAB11A-dependent recycling pathway (By similarity). Localizes to the apical membrane in intestinal epithelial cells (PubMed:16950140, PubMed:20699218). Mainly localized on the basolateral side of renal tubular cells (PubMed:19144690). Localizes to the neuronal cell body plasma membranes (By similarity). {ECO:0000250|UniProtKB:O15431, ECO:0000250|UniProtKB:Q9JK41, ECO:0000269|PubMed:16950140, ECO:0000269|PubMed:19144690, ECO:0000269|PubMed:20699218}.
Interaction partners:
- Copper transport protein ATOX1
- Copper-transporting ATPase 2
- Copper-transporting ATPase 1
- Cytochrome c oxidase copper chaperone
- Copper chaperone for superoxide dismutase
- Natural resistance-associated macrophage protein 2
- Solute carrier family 22 member 2
- Ceruloplasmin
Sequence:
MNHMGMNHMEMHHHMGMNHTDDNITMPPHHHPTTSASHSHGGGDSMMMMPMTFYFDFKNVNLLFSGLVINTPGEMAGAFVAVFLLAMFYEGLKIAREGLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH
Protein: Large ribosomal subunit protein uL13m (39S ribosomal protein L13, mitochondrial) (L13mt) (MRP-L13) (Q9D1P0)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9BYD1}.
Interaction partners:
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein bS16m
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL15m
Sequence:
MSSFSRAPQQWATFARMWYLLDGKMQPPGKLAVIASNKLQGLNKPVYHQLSDCGDHVVIINTRHIAFSGNKWEQKVYSSHTGYPGGFRQVTAAQLHRKDPVAIVKLAIYGMLPKNLHRRTMMQRLHLFPDEDIPEDILKNLVEELPQPRRVPKRLDEYTQEEIEAFPRVWTPPDDFRM
Protein: Tyrosyl-DNA phosphodiesterase 1 (AtTDP) (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) (Q8H1D9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue.
Subcellular location: Nucleus {ECO:0000269|PubMed:20876339, ECO:0000269|PubMed:22214184}.
Interaction partners:
- DNA topoisomerase 1 alpha
- DNA topoisomerase 1 beta
- Transcription factor bHLH140
- Crossover junction endonuclease MUS81
- ATP-dependent DNA helicase 2 subunit KU70
- DNA-repair protein XRCC1
- At1g11800/F25C20_3
- ATP-dependent DNA helicase 2 subunit KU80
- DNA binding / DNA topoisomerase type I
- DNA repair endonuclease UVH1
Sequence:
MAHSQVAYLIPLKADLKEDNSSPRITLSEGPNIIGRGNVSIVDKRLSRKHITIIVSTSGSASLSVDGTNPVVIRSSGDGERKKVKPSEEVSVCNDDLIELIPGHHFFKLVLLNGRAAKKARKAEDDVEAIRRFCPPNEKLPSTFRLLSVDALPDWANTSCVSINDVIEGDVVAAILSNYMVDIDWLMSACPKLANIPQVMVIHGEGDGRQEYIQRKKPANWILHKPRLPISFGTHHSKAIFLVYPRGVRVVVHTANLIHVDWNNKSQGLWMQDFPWKDDDKDPPKGCGFEGDLIDYLNVLKWPEFTANLPGRGNVKINAAFFKKFDYSDATVRLIASVPGYHTGFNLNKWGHMKLRTILQECIFDREFRRSPLIYQFSSLGSLDEKWLAEFGNSLSSGITEDKTPLGPGDSLIIWPTVEDVRCSLEGYAAGNAIPSPLKNVEKPFLKKYWARWKADHSARGRAMPHIKTFTRYNDQKIAWFLLTSSNLSKAAWGALQKNNSQLMIRSYELGVLFLPSPIKTQGCVFSCTESNPSVMKAKQETKDEVEKRSKLVTMTWQGDRDLPEIISLPVPYQLPPKPYSPEDVPWSWDRGYSKKDVYGQVWPR
Protein: Mitogen-activated protein kinase kinase kinase 19 (Protein kinase-like protein) (Q9FHA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEWIRGETIGYGTFSTVSLATRSNNDSGEFPPLMAVKSADSYGAASLANEKSVLDNLGDDCNEIVRCFGEDRTVENGEEMHNLFLEYASRGSLESYLKKLAGEGVPESTVRRHTGSVLRGLRHIHANGFAHCDLKLGNILLFGDGAVKIADFGLAKRIGDLTALNYGVQIRGTPLYMAPESVNDNEYGSEGDVWALGCVVVEMFSGKTAWSLKEGSNFMSLLLRIGVGDEVPMIPEELSEQGRDFLSKCFVKDPKKRWTAEMLLNHPFVTVDVDHDVLVKEEDFVVNMKTEDVSTSPRCPFEFPDWVSVSSGSQTIDSPDERVASLVTDMIPDWSVTNSWVTVR
Protein: Interferon gamma (Interferon, gamma precursor) (Q5QRA1)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MDVLSRAVMCFCLMGWMTLGWSNAAQYTSINMKSNIDKLKVHYKISKDQLFNGKPVFPKDTFEDSERRVWMSVVLDVYRSIFNQMLNQTGDQEVRERLDQVKGKVQETQKHYFLKRIPELRTHLQNLWAIETSNTTVQGKALSEFITIYEKASKLALKIHLKKDNRRKRRQAQRLKSSIM
Protein: DMA protein (MHC class II antigen) (Major histocompatibility complex, class II, DM alpha) (cDNA FLJ75740, highly similar to Homo sapiens major histocompatibility complex, class II, DM alpha (HLA-DMA), mRNA) (Q31604)
Organism: Homo sapiens (Human)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004352}.
Interaction partners:
Sequence:
MGHEQNQGAALLQMLPLLWLLPHSWAVPEAPTPMWPDDLQNHTFLHTVYCQDGSPSVGLSEAYDEDQLFFFDFSQNTRVPRLPEFADWAQEQGDAPAILFDKEFCEWMIQQIGPKLDGKIPVSRGFPIAEVFTLKPLEFGKPNTLVCFVSNLFPPMLTVNWQHHSVPVEGFGPTFVSAVDGLSFQAFSYLNFTPEPSDIFSCIVTHEIDRYTAIAYWVPRNALPSDLLENVLCGVAFGLGVLGIIVGIVLIIYFRKPCSGD
Protein: Uncharacterized protein (Q385V0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPGIERLREEVEQLRSETNRLKENLKLQNPQSVRERSGSDRQHMEVESFRAQIRKHHADAPILKLHDELLRAEQRCTQYADALAESKGNFVNMKRLYQELSDILDGCSA
Protein: Homeobox protein invected (P05527)
Organism: Drosophila melanogaster (Fruit fly)
Function: Engrailed (en) and invected (inv) are functionally redundant transcription factors in neuronal precursor cell NB5-3 specification. Inv is unable to substitute for en in other regulatory processes such as maintaining gsb expression in the neuroectoderm after stage 10 of embryogenesis. Maintenance of gsb expression in row 5 of the neuroectoderm involves an as yet unidentified short range signaling molecule.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:2892756}.
Interaction partners:
- Segmentation polarity homeobox protein engrailed
Sequence:
MSTLASTRPPPLKLTIPSLEEAEDHAQERRAGGGGQEVGKMHPDCLPLPLVQPGNSPQVREEEEDEQTECEEQLNIEDEEVEEEHDLDLEDPASCCSENSVLSVGQEQSEAAQAALSAQAQARQRLLISQIYRPSAFSSTATTVLPPSEGPPFSPEDLLQLPPSTGTFQEEFLRKSQLYAEELMKQQMHLMAAARVNALTAAAAGKQLQMAMAAAAVATVPSGQDALAQLTATALGLGPGGAVHPHQQLLLQRDQVHHHHHMQNHLNNNENLHERALKFSIDNILKADFGSRLPKIGALSGNIGGGSVSGSSTGSSKNSGNTNGNRSPLKAPKKSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPVDLVKSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKKSSGTKNPLALQLMAQGLYNHSTIPLTREEEELQELQEAASAAAAKEPC
Protein: Hemoglobin subunit beta-1 (Beta-1-globin) (Beta-A1-globin) (Hemoglobin beta-1 chain) (Q90486)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in oxygen transport from gills to the various peripheral tissues.
Interaction partners:
- Hemoglobin subunit alpha
- Hemoglobin subunit alpha-D-like
- Hemoglobin, alpha adult 2
- Hemoglobin, alpha embryonic 5
- Hemoglobin alpha embryonic-3
- Embryonic alpha globin e1
- Hemoglobin subunit alpha
- Hemoglobin, alpha embryonic 1.3
- Hemoglobin beta embryonic-3
- Embryonic globin beta e2
Sequence:
MVEWTDAERTAILGLWGKLNIDEIGPQALSRCLIVYPWTQRYFATFGNLSSPAAIMGNPKVAAHGRTVMGGLERAIKNMDNVKNTYAALSVMHSEKLHVDPDNFRLLADCITVCAAMKFGQAGFNADVQEAWQKFLAVVVSALCRQYH