wanglab/gogpt-training-data huggingface dataset:
Protein: Os02g0564700 protein (cDNA, clone: J075076G04, full insert sequence) (Q6Z7E7)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Os10g0491801 protein
- Ubiquitin-ribosomal protein eS31y fusion protein
- Ubiquitin-ribosomal protein eS31z fusion protein
Sequence:
MGGFAYPFTPSPAWSRDAVFAGSPWAAGGVSSLADALVSYGAVDDEEAAFLGKTAASSPSTARLHEQQQLLLEAELLRHGDGLGFAAMDDDGGAAMLGALEPCAMPLTDSGGPPVICSSSSNDSSGSEHSAAMPAGGGFLVGEQQQHVPPAAYAAGGVLPSMAAGEETPQSFGFGSLFNGDLLQEATVSKYHHHQQQQQLGVVPSSQPHHLNDDIDFNTGKLMSFASGQQHVTPSIDSLQIDQKEFSSGLHHLNLSSLISGPLASFNATQSHRQPAEACGGKNGGAAPFVNLSEVLPKGNGSGSAGNGAPKPRVRARRGQATDPHSIAERLRREKISDRMKDLQELVPNSNKTNKASMLDEIIDYVKFLQLQVKVLSMSRLGAAEAVVPLLTETQTESPGFLLSPRSSSGERQAGAGAVTGGLPGDQPELLDGGAMFEQEVVKLMEDNMTTAMQYLQSKGLCLMPVALASAISAQKGTSSAAVRPEKKKNGDGDGGGDEEDVKGEFDAPRRPPVGRPKEMRSRV
Protein: Polyubiquitin 8 [Cleaved into: Ubiquitin-related 1; Ubiquitin-related 2; Ubiquitin-related 3; Ubiquitin-related 4; Ubiquitin-related 5; Ubiquitin-related 6; Ubiquitin-related 7; Ubiquitin-related 8] (Q39256)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- E3 ubiquitin-protein ligase UPL4
- E3 ubiquitin-protein ligase UPL3
- Protein NBR1 homolog
- E3 ubiquitin-protein ligase PRT1
- Ubiquitin-conjugating enzyme E2 13
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL18y
- E3 ubiquitin-protein ligase UPL5
- Ubiquitin-conjugating enzyme E2 variant 1A
Sequence:
MTIQIYAKTLTEKTITLDVETSDSIHNVKAKIQNKEGIPLDQQRLIFAGKQLEDGLTLADYNIQKESTLHLVLRLRGGMQIFVQTLTGKTITLEVKSSDTIDNVKAKIQDKEGILPRQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLCGGMQIFVSTFSGKNFTSDTLTLKVESSDTIENVKAKIQDREGLRPDHQRLIFHGEELFTEDNRTLADYGIRNRSTLCLALRLRGDMYIFVKNLPYNSFTGENFILEVESSDTIDNVKAKLQDKERIPMDLHRLIFAGKPLEGGRTLAHYNIQKGSTLYLVTRFRCGMQIFVKTLTRKRINLEVESWDTIENVKAMVQDKEGIQPQPNLQRLIFLGKELKDGCTLADYSIQKESTLHLVLGMQIFVKLFGGKIITLEVLSSDTIKSVKAKIQDKVGSPPDQQILLFRGGQLQDGRTLGDYNIRNESTLHLFFHIRHGMQIFVKTFSFSGETPTCKTITLEVESSDTIDNVKVKIQHKVGIPLDRQRLIFGGRVLVGSRTLLDYNIQKGSTIHQLFLQRGGMQIFIKTLTGKTIILEVESSDTIANVKEKIQVKEGIKPDQQMLIFFGQQLEDGVTLGDYDIHKKSTLYLVLRLRQRRYDF
Protein: Rifin (Q8I641)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKLHCSKILLFFFPLNILVTSYHVYSKNKPSITSHHTQTNRSLCECDTQSTNYNNDEEIKSVKENFDRQASQRFEEYEERMKEKRQKCKEQRDKSIQEIIEKDKREKSLAQKVEKGCLICGCGLGSVAGSVGIFGTVAVKELTKAAIAKAVVVAKEAGMAAAKAEGAAAGKEFVIAKLQEMGISTVGVQGLQSYFVTTDYTNALTIFRAINNQYSPSSCIFVSSGTRQAFCTWVTEQSKSVANIREMLQGNSVSYTKVTEKAVGTIVTDAKKAAGEATEKAIEEVIQRSTAAAESTYAGCQSAIIASVVAIIIIALVMIIIYLVLRYRRKKKMKKKAEYTKLLNQ
Protein: Leucine-rich repeat protein (LRRP), putative (Q4GY77)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGGVVGKIPVLLRGGKTVDGLNFHGMVPIDTEELTELLTVLNCRGYDTKVEVHPLPAGFPHTGEVFSTYELVLRGIVLERGDLEFIGNYASLNKLHFIECSGSCDLGMLSGHSFLSELRVDVDGEVSHYKALRELPSLRTLWLRNSNMTLTDFFHVGEVDTLESLTLRGALNFKCLEAVARLPRLRALDLSETLVNDKCLHAISACKTLQQLGLSSCKRLRDVSPLTQIASLEELNLSHCENLKEVGALYRLSHLFRLDLRGVHLTYRVVYSLSKCTGLTELYVSSCEGLSGVAWLSNLESLGDLDVQWRKNLKHTGDVLACLPLLRVLDLSGTSISNESLWNISESKLLRRLDLSFCGGVKDISPISDIVTLEELNLKGCTSITEGVDKLGNLVNLHILNMSNTPLQSGFLYNISSIESLVELDLSSCWGVASLDSSVQTAVRMRKGSYPLARHIEGINALGRLPKLRLLNMSSTPVTDECLHGLQMCKSLVWLNLSLCANLTDVSPLSSVKTLEEVDLGCCGNLKWGAGSLRRLPQLRILDLKNTVITDHCLGDVTYGGGVVSRMLGRCGMADLSFSRWSIRRGGNLVRLDLSSCWGLTDIAHLTSITTLEELRFTGCRNLKDGVDALGQLPVLHLLDLSGTSITDDSLQGLSTCRSLVTLNISSCANLTDVSPLSRISSLEELNLQKSKHIRRGIDELVSLPRLYLVYLCRADFSRGVAEELEKRGIVVKQM
Protein: Mitochondrial ribosomal protein S36 (Q9D6T9)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MGSKMASATRVVQVVKPHAPLIKFPNRRDKPKLSEALGSAALPSHSSAISQHSKGSTSPDLLMHQGPPDTAEIIKSLPQKYRRKPMSQEEMEFIQRGGPE
Protein: Thyroid adenoma-associated-like protein (F4JFA0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative tRNA
- Putative rRNA methyltransferase
- rRNA methyltransferase 2
Sequence:
MSAKWRALQHRHRYTYSAVLFPSSFTASLSQSSLSQSCPKFYSNIEELVSLNSIYAQVNHAKKVVASFGEFLAKANENEGGERETVSVREAIRFYLEILFMENSLPLHKTLVSALAKTTKFHSVISSCFKELCDEYGGFEDGGNRFCVSRVALSVMGMPKLGYLVDIIEDCALLVGYDIVSGLNGIVLDTEACDRPPPTVMEQCQEALSCSYYLFQRFPLKFKGLVGEDASFMESVLAVQVSILKSLAFSRDCYVAAGVSFCAALQVCLKDEELGLFIAQCIFCWSSVVRLADIVSKIPFAGDICSEICSFSSLSRLCLIRGILTTVSRGILVSSFARLSNSDCDHKTILYDGILLELCDLCENPIDSHLNFHVLTVMQICMQQIKTSMLTDLSEGYDPMPDSMAARVLRIIWNNLEDPLSQTVKQVHLMFDLLLDIQTTVHQTDDKVGMRESLLKIVNYLLRLGSRCKGRYVPLASLTRRLGAKTLMDMSPNLLFEMANAYIDDDVCYAVTSFIKCFLELLRDESWGSEGVDQGYARYREHCLPPFLYGLASGKSKLRSNLNTYAVQVLLELDVDSIFLLLAYISIGPSEEETKLNYTELSNMSMELTVEQKVVVLVSLLKVCRTLAFLEGDIEQKRSTDAFAVVQIKGIELKIPIEWLKMALTHVDESVRVDAAETLFLNPKTSSLPSPLELYLMKEAVPLNMRSSSTGFQMKWTSLFRKFFLRVRTSLEKQYKLGSLQPLKSDKNAVLRAESLFKFMRWLSSFLYLSCYPSAPYRRKIMATELIQIMIEVWPVVASKDPTSHQGHLYPYCDIVTSHDSTLLLVGSIVDSWDRLRENSFRILLHFPTPFTGISSEDMVQIIIPWAKQLVCSPRVRESDAGALTLRLIFRKYVLDLGWIVKVSTTVFCCERECENIDCRNQNSKPKYPVVEYIKSLIQWLDASVTEGERDLSEACKNSFVHGVLLALRYTFEELDWNSNAVLSISEMRKELEKLLKLVTRITTLALWVVSADALCLPEDMDDIIDDDSFFSNVQDDSAAVLSEEHTSTYPKHVHETVQSEQVVMVGCWLAMKEVSLLLGTIIRKIPLPTSSLRPLENGDTASSVPNDLVIGNSESLLDLKQLEKIGDHFLEVLLKMKHNGAIDKTRAGFTALCHRLLCSNDPRLCKLTESWMEQLMERTVAKGQTVDDVLRRSAGIPAAFIALFLSEPEGSPKKLLPRALRWLIGLAEKPLMEPLEQKGSKHMVEEINSSDMHSNEKLSKVRDEGVVPTVHAFNVLKATFNDTNLSTDTSGFSAEAMIVSIRSFSSPYWEVRNSATLAYTALVRRMIGFLNVQKRGSTRRALTGLEFFHRYPLLHPFIYSELKAATDLLDTSGSSDSNLANLVHPSLWPILILLSRLKPSPIASESGDDLDPFVFMPFIMKCSTQSNLRVRVLASRALVGLVSNEKLQSVLLRIASTLPSNGAQGGSFNYLHGILLQLGNLLDTNCRDLADNSKKDQIIGKLINVLANCSWLASPLTCPCPILCTSFLRVLDHMRVIEWTCSESKNLRDIYKLHLDLSTNCLDADASYGFSYYDPSIAELREQAAVSYFGCVFQPSDEAAEVFQITQRPNLQSQKVPEALDFPHLNERLLRCISDQSYEVRLATLKWFLRFLKSEDSSFSESSSIWNWAKNGLQVILLELLDKEKNHKCENYILRILFQWNLLMFKKSCNKESVEGIYVGSLNYDSVFHLWGRLTSLYESTRRAKTRGTLMCCLAICVKHLTGLFIHKNESEKEEEPRWSCITDCVSYFVNLIKQKSLPSEQVNVRHASAEAIIASGILEQAKLIGPLVSNHQISSETTPSKFQKACDVYAYQILEMWFTCIKLLEDEDDVIRSKLATDVQKCFFTAVEVPTQVDKVLELSFNHLSSILGHWNEYSQYLSRWVFNTADYTSPPKGGSDLVRRVFDKEIDNHHEEKLLILQFCCYHLQKLPNRDFSLAQLLDWRSKFHNQLLAFAKDHVSKQRESWVGGVGNHKDVFLPLYGNLLGLYVFSDCIFRFSTDSNDKKTLFSDIIELGEALKPFLRNPLVSNMFRVVVRLHEKLLNDSLMDLSTVLSGEIWEGFDPYFLLTEGEIKVRSFYSDESGACSPPLG
Protein: RNA-binding protein, putative (Q38D54)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQGGNMFDEHSSASCPQRDPEDGDRRQNHGNILFVGNIPFQTPWQHVKDHFRSAGKVRYTDLIADKTGRPKGSALVTMATREDALQAIRMFDETDFEGRRLIVRLFDDGPRPQLVQREMMPPYVRQGQLQQPQHHQQQHHPPHQQQQQQQQQQQQQQHQQRMRGFGNANANMTSYNNSAGNFGRGGGYVNRGGYALPDDGNSGVFNDVNEVVPKPRSKQMNEVGRKLFVSNLPFDCTSVALRETFQQVGEVERAEIIMGRNGKSRGMGIVVMKTEEETRVAIEEFDGIEMANRAMNVRLDNKSTS
Protein: Protein deltex (Probable E3 ubiquitin-protein ligase deltex) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase deltex) (Q23985)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8150285}. Endosome, multivesicular body {ECO:0000269|PubMed:22162134}. Note=Colocalizes with N/Notch on multivesicular bodies. {ECO:0000269|PubMed:22162134}.
Interaction partners:
- E3 ubiquitin-protein ligase Su
- Neurogenic locus Notch protein
- Kurtz arrestin
- Neurogenic protein mastermind
Sequence:
MASSAGSAASGSVVPGGGGSAASSCATMALSTAGSGGPPVNHAHAVCVWEFESRGKWLPYSPAVSQHLERAHAKKLTRVMLSDADPSLEQYYVNVRTMTQESEAETAGSGLLTIGVRRMFYAPSSPAGKGTKWEWSGGSADSNNDWRPYNMHVQCIIEDAWARGEQTLDLCNTHIGLPYTINFCNLTQLRQPSGPMRSIRRTQQAPYPLVKLTPQQANQLKSNSASVSSQYNTLPKLGDTKSLHRVPMTRQQHPLPTSHQVQQQQHQHQHQQQQQQQHHHQHQQQQHQQQQQHQMQHHQIHHQTAPRKPPKKHSEISTTNLRQILNNLNIFSSSTKHQSNMSTAASASSSSSSASLHHANHLSHAHFSHAKNMLTASMNSHHSRCSEGSLQSQRSSRMGSHRSRSRTRTSDTDTNSVKSHRRRPSVDTVSTYLSHESKESLRSRNFAISVNDLLDCSLGSDEVFVPSLPPSSLGERAPVPPPLPLHPRQQQQQQQQQQQLQMQQQQQAQQQQQQSIAGSIVGVDPASDMISRFVKVVEPPLWPNAQPCPMCMEELVHSAQNPAISLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIVYGEKVGNQPIGSMSWSIISKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYLPDCPLGRKVLRFLKIAFDRRLLFSIGRSVTTGREDVVIWNSVDHKTQFNMFPDPTYLQRTMQQLVHLGVTD
Protein: Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) (Deamido-NAD(+) diphosphorylase) (Deamido-NAD(+) pyrophosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase) (P0A752)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Interaction partners:
- Nicotinamide-nucleotide amidohydrolase PncC
- NH
- Nicotinate phosphoribosyltransferase
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Ribosomal silencing factor RsfS
- Trifunctional NAD biosynthesis/regulator protein NadR
- NAD kinase
- Adenosylcobalamin/alpha-ribazole phosphatase
- DNA polymerase III subunit delta
- LPS-assembly lipoprotein LptE
Sequence:
MKSLQALFGGTFDPVHYGHLKPVETLANLIGLTRVTIIPNNVPPHRPQPEANSVQRKHMLELAIADKPLFTLDERELKRNAPSYTAQTLKEWRQEQGPDVPLAFIIGQDSLLTFPTWYEYETILDNAHLIVCRRPGYPLEMAQPQYQQWLEDHLTHNPEDLHLQPAGKIYLAETPWFNISATIIRERLQNGESCEDLLPEPVLTYINQQGLYR
Protein: Formate dehydrogenase, alpha subunit, selenocysteine-containing (EC 1.2.1.2) (Q728X0)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
Interaction partners:
- Formate dehydrogenase, beta subunit, putative
- Formate dehydrogenase 2 subunit beta
- Formate dehydrogenase, beta subunit, putative
- Pyridine nucleotide-disulfide oxidoreductase
- Iron-sulfur protein CooF
- Formate dehydrogenase 2 subunit alpha
- Formate dehydrogenase, alpha subunit, selenocysteine-containing
- Carbon monoxide dehydrogenase
- Formyltetrahydrofolate deformylase
- Formamidase
Sequence:
MRMPRRTFIKLASASAGALAFAGLGQSLAPTVARAAELKIAKAKVTPSVCCFCAVGCGLLVYTDTQTGRSINIEGDPDHPTNEGTLCPKGASIWQTTERSKRVTKVLYRAPGAAAWEEKSWDWALPRIARKIKETRDATFELTNDKGQTVNRTRGIASVGSAAVDNEEGWLMQAMMRALGLVYIESHARIUHSSTVGALAESYGRGAMTNHWIDLKNSDVILIMGSNAAENHPISFKWVTRAQERGATLIHVDPRFTRTSAKADIHAHIRSGTDIAFFGGLIRYIMENDLFFRQYVVDYTNASYIVGADYGFADGLFTGFDAEKGTYNTKKWAFAADENGMTLKDPTLNDPRCVFQLMKAHYARYDRKTVSDVTGISEEQLATLWSTFASTGKPDRAGTILYAMGQCQHTVGVQNIRALSMIQLLLGNIGIAGGGVNALRGESNVQGTTDISLLCDNLSGYLPTPKASWATFDDYVKGTTPVDKDPKSANWWSNRGKYLASYMKSVYPTASHQDGYLWHPKVDDGKITDYSWLQIFERMSKGGFKGAFVWGQNPCAGGANAGKNRKAMETLDWMVVVNLFENESSLFWKGPGVDPAKVKTEVFFLPACMSVEKGGSIANSGRWLQWREPGPKPMGDSRSDGDIVLDLYDEIRKLYREEKGAFPEPVLALDTDYRTDGKYDHHKVAKTLNGKFLTDVTIGDKTYKAGQQVPGFAMLQADGSTTSGCWIFTGCYTDAGNMMARRDRTQTPEQAAIGLFPNWSYAWPANRRILYNRAAVDMTGKPFDPKRAVIAWNGEKWVGDVPDGGWKPGEKLPFIMIREGRGQLFGPGRVDGPFPEHYEPFESPLESHPFSKQRVNPTALAFSHEPKAVRDKRYPFICTTYRVTEQWQSGTMTRNTGWLKEMQPEGFCEISRELAKELGIANGDAVVLESLRGKVQVVAIVTPRLKPFKVMGEVMHEVGIPWQFGWGQHVGKGDSANLLSPSVGDPNTGIPETKVFMVNLRKA
Protein: Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike protein S2; Spike protein S2'] (A0A6G6A1M4)
Organism: Pangolin coronavirus
Subcellular location: Host endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000256|ARBA:ARBA00034689, ECO:0000256|HAMAP-Rule:MF_04099}; Single-pass type I membrane protein {ECO:0000256|HAMAP-Rule:MF_04099}. Virion membrane {ECO:0000256|HAMAP-Rule:MF_04099}; Single-pass type I membrane protein {ECO:0000256|HAMAP-Rule:MF_04099}. Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04099}; Single-pass type I membrane protein {ECO:0000256|HAMAP-Rule:MF_04099}. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion. {ECO:0000256|HAMAP-Rule:MF_04099}.
Interaction partners:
Sequence:
MFVFLFVLPLVSSQCVNLTTRTGIPPGYTNSSTRGVYYPDKVFRSSILHLTQDLFLPFFSNVTWFNTINYQGGFKKFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLIVNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRVYSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDGYFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQTLLALHRSYLTPGKLESGWTTGAAAYYVGYLQQRTFLLSYNQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFRVQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRISNCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADSFVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSVKQDALTGGNYGYLYRLFRKSKLKPFERDISTEIYQAGSTPCNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSFELLNGPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQFLPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAGANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSFRSVNQRSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSIECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHEGKAHFPREGVFVSNGTHWFITQRNFYEPQIITTDNTFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
Protein: DNA-directed DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-) (Gene product 43) (Gp43) (P04415)
Organism: Enterobacteria phage T4 (Bacteriophage T4)
Function: Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction for proofreading purpose.
Interaction partners:
Sequence:
MKEFYISIETVGNNIVERYIDENGKERTREVEYLPTMFRHCKEESKYKDIYGKNCAPQKFPSMKDARDWMKRMEDIGLEALGMNDFKLAYISDTYGSEIVYDRKFVRVANCDIEVTGDKFPDPMKAEYEIDAITHYDSIDDRFYVFDLLNSMYGSVSKWDAKLAAKLDCEGGDEVPQEILDRVIYMPFDNERDMLMEYINLWEQKRPAIFTGWNIEGFDVPYIMNRVKMILGERSMKRFSPIGRVKSKLIQNMYGSKEIYSIDGVSILDYLDLYKKFAFTNLPSFSLESVAQHETKKGKLPYDGPINKLRETNHQRYISYNIIDVESVQAIDKIRGFIDLVLSMSYYAKMPFSGVMSPIKTWDAIIFNSLKGEHKVIPQQGSHVKQSFPGAFVFEPKPIARRYIMSFDLTSLYPSIIRQVNISPETIRGQFKVHPIHEYIAGTAPKPSDEYSCSPNGWMYDKHQEGIIPKEIAKVFFQRKDWKKKMFAEEMNAEAIKKIIMKGAGSCSTKPEVERYVKFSDDFLNELSNYTESVLNSLIEECEKAATLANTNQLNRKILINSLYGALGNIHFRYYDLRNATAITIFGQVGIQWIARKINEYLNKVCGTNDEDFIAAGDTDSVYVCVDKVIEKVGLDRFKEQNDLVEFMNQFGKKKMEPMIDVAYRELCDYMNNREHLMHMDREAISCPPLGSKGVGGFWKAKKRYALNVYDMEDKRFAEPHLKIMGMETQQSSTPKAVQEALEESIRRILQEGEESVQEYYKNFEKEYRQLDYKVIAEVKTANDIAKYDDKGWPGFKCPFHIRGVLTYRRAVSGLGVAPILDGNKVMVLPLREGNPFGDKCIAWPSGTELPKEIRSDVLSWIDHSTLFQKSFVKPLAGMCESAGMDYEEKASLDFLFG
Protein: G1/S-specific cyclin-D1 (Q90459)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P24385}. Cytoplasm {ECO:0000250|UniProtKB:P24385}.
Interaction partners:
- cyclin-dependent kinase
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase inhibitor 1
- cyclin-dependent kinase
- Glycogen synthase kinase-3 beta
- Retinoblastoma 1.
- cyclin-dependent kinase
- Retinoblastoma-like protein 2
- Glycogen synthase kinase-3 beta
- Transcriptional regulator Myc-A
Sequence:
MEHQLFCCEVDTIRRAYQDSNLLNDRVLQTMLKAEENYLPSPNYFKCVQKEIVPKMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKTRLQLLGATCMFLASKMKETVPLTAEKLCIYTDNSVRPGELLQMELLALNKLKWDLASVTPHDFIEHFLAKLPIHQSSKQILRKHAQTFVALCATDVNFIASPPSMIAAGSVAAAVQGLYLKSTDSCLSSQNLTNFLSQVIRSDPDCLRSCQEQIESLLESSLRQAQQHISTETKRVEEDVDLSCTPTDVRDINI
Protein: Phospholipid phosphatase-related protein type 1 (Inactive 2-lysophosphatidate phosphatase PLPPR1) (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3) (Q6WAY2)
Organism: Rattus norvegicus (Rat)
Function: May play a role in neurite outgrowth and neurogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14750979}; Multi-pass membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000269|PubMed:14750979}.
Interaction partners:
Sequence:
MAVENNTQRSYSIIPCFIFVELVIMAGTVLLAYYFECTDTFQVHIQGFFCQDGDLMKPYPGTEEESFISPLVLYCVLAATPTAIIFIGEISMYFIKSTRESLIAEEKMILTGDCCYLSPLLRRIVRFIGVFAFGLFATDIFVNAGQVVTGHLTPYFLTVCQPNYTSTDCRAHHQFINNGNICTGDLEVIEKARRSFPSKHAALSIYSALYATMYITSTIKTKSSRLAKPVLCLGDLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVVHNFKGTQGSASKPKPEDPRGVPLMAFPRIESPLETLSAQNHSASMTEVT
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (H7BYH4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATKAESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Protein: Uncharacterized protein (Q3UV10)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MAGNTPQLEKDVNPQTSIEPSVQVKCPGDILQGGRHAKRGRWMASWKGFHLGRRDSDCKMNITVDQDTDYAELVLSVGEITLGEKTRDSMKDSQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDGMGLDLVNPLPGILHLPHDYLDFMQYNDYFFVFVKPWKPNQRGPGIATWKTNLYKRIFSFSVELKAADAVQFLKSRPSSHGKTVCNETLNECLSLFNRDWLAYEETFCFTKSTHAEVKLTPKEKISPKEKILELLPQTVSAFANTDGGYLFIGLDGKTQQIIGFEAEKSDLVLLESEIEKCIQQLPVTHFCEEKEKIKYTCKFIEVHKSGAVCAYVCAIRVEKFCCAVFAAEPESWHVEGSCVKRFTTEEWVKRQMDATAVMPGKVICSPEALCMKPFSQHEGYEQLVRTELGSLRKGTLVVSKSWALDLGLQEKQEVIWDVLHISQGSLLTLHVFVQGDENLEGNSSLLGELGAELKGYYKQIALTLKQTLVNHCGYTAKIGIIVKITYLGHKTMCLYDSSAKICYPQIYYLTTKAVKDLEKALAEILGSYESFYSLPRRNWDSFMSAFLNVGSYIVYFSRNVLTHIRI
Protein: Apolipoprotein B (Q29021)
Organism: Sus scrofa (Pig)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Lipid droplet {ECO:0000256|ARBA:ARBA00004502}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
GSTSHHLLSRRSMNTALDHKVSALLTLAEQTGTWKLKTQLNQNEYSQNFDAYNTKDKVGVELNGRGLADLTVLDSTITVPLLLSEPINVIDALEMRDTVDQPQEFTVVASVKYDKNQNHHTINLPFFNILPEYFEKTRLVGIVALEAIQRELKHININQPMRKYGAALDKFPQQVNDYLSTFSWERQVLSAKKKLSDFMEDYRITENDVRIALDNAKINLNEKLTQLQTYVIQFDQYIKDNYDLHDFKTAIARIIDEIIATLKILDERYHIHVNLVKKIHDLHLFIEKIGFNKTRSSTASWFQNVNINYQIRLWIQEKLQQLKAQIQNIDIQHLAEKLKQQVEDIDARVLLDQLRTTIPFQEIKEVIEHVKYCVKSLFEDFEVTKEINAFRAMVHELIKMYKIDEHIQVLMDNSVHLAHQYKLQETVQKLSSILQQVKIQDLLETLTWFIDDTLKQLEALSFQQLIEEVNKFLDMLVKRLRSFDYHHFLDETNKNLHEVTQRINGKIQALELPQKFTALKLLSEDIKALISVHLENLKATKITLFFDWLQGTLSSTPIVHMKAKFHETLEDVRDRMYQMDVQQEIQRYLFLVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKNLKALVEQGFTVPEIQTTFGTLPAFEVSLRALQEATYQTPDFIVPLTDLKIPSVQINFKKLRDIEIPSRFSTPEFTVLNTFHVPSFTIDLVEIKAKIIRTIDQMLNSELQWPVPEVYLRDLNGVETMLARITLPDLYLPEIRIPEFVIPNLNLTDFQVSDLHIPEFQLPHIPHTVEVPAFGKLHGILKIQSPLLILEANANIQNITTSENTAEMEASFTAKGESKFEVLNFDFQANAQLSDPEINPLVLKESVRFSSKYLKTEHGSEVLFVGNSIEGKSNTVAGLYTGKNTLKLSNDVLLKVNNQLTLNSNTKYFHELNIPKLDFSSQADLRSEIKSLLEASHIAWTSSGKGSWKLACHRFSDEGTHESQISFTVEGPITSFGLSNEIRSKHLRVNQSMVYESAFLKFSKFEIHSQAECQYVGRSVLTAKGMVLPRERKAEITGNHDAHLNGKVIGTLKNSLFFSAQPLEITRSTINEGNLRVSFPLKLTGKIDFLNNYALLLSPSAQQASWQASARFNQYKYNQNFSAVNNERSTEAHIGINGEANLDFLNIPLTIPEMTLPYTRLTVPQVKDISLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKDKHSIPNPLDVFYAFINRNINSFNRHFETVRDKALDFFTESYNEIKITFDKYKVEKPLDQQPRTFQIPGYTIPVINIEVSPFTVKMLTFGYVIPKEISTPNITILGSGISVPSYTLGLQFLELPALDVPRNILQISLPELAVSGTSNKILIPAMGNITYDFSFKSSVITLNTNVGLYNQSNIVAHFLTFSSSVIDALQYKLEGTSSLMRKRGLKLATALSLSNKFMEGNHDSTISFTKKNVDASLTTTARVQLPILRMNFKQELKGNTKSKPTISSSIELKYDFNSPKLHSTAAGAVDHKLSLESLTSYFSIEMSTKGDVKGSILSRVYSGSLASEASTYVNSKGTRSSVKLQGASKVDDIWNLEVKENFAGEATLLRIYTIWEHHTKNHLQLEGLILTSGEHTSKATLELSPWNIAALVQVHTRQPSSLLNIHYLSQEVSLNANTENQKISWKSQVQVHSGSLQNNLQLSNDKEEARFDISGSVEGYLSFLKYTVLPVYDMSLWDLLKLDVTTSINRKQYLRASTALVYTKNPNAYPVSIPVQELTDKFIIPGLKLNNLKSVYVTPAFQVPFTDLRFPSYTLDFSEIKIYKKLSTSSFSLNIPTLPKVKFPKVDVLTQYSNPETSSVPFFEVTVPAYQLTVSPFTLPKSISVGSAVLDLDVVASYIADFEVPTVTMPEQTIEIPSIKFSVPAGISLPSFGTLTARFGVASPLYNATWSAGLKNKEDRVETFLDSTCSSTIQFLEYDLNVVGTHKIEDGMLVCSTKGSFAHRDLSAEYEENGKYHGLEYWDGKIILNITSPTLTDVYLRYQQSKNHLFSSLASPAIGTVALEQENINTSLKSNLYYRPQSSPDKKLNIFKIEKRDLESDEDVQIKANWEEEAVSELLRSLKDNVPKATGAFYDYVNKYHQEYTGLDLRDASLKLRKGLQNSADQAYQGAVRQIDEVDRGLRKIARGTTKSYQQWKDRAQSLYQKLLAQEDQGDFQGLRNKVFDSVIGVTQEYNVTVKRAVDSLIKSLKFTRFQLPGRARNYTGDELCNMVMTEVGEVLSQIYSKIHSGLEILLSYFQDLMEKSKLNKARKIKFTFDSVKYQLTDVVSEYGEQLKSLSQDVQKALSDLHSINITEILSELQIFLEGIFQEIEEELTRLKEKKLADFINDIQQNINTTFNIYAPLGFRLLKENLDSPFGMLNEFIQNTLWEASQELQQLHQYIKALRKEYFDPSMVGWTVKYYELEEKVINLIKNLVDVLKDFHSKYTVSATDFASQLSSQVEQFVQEDIQEYLSILADADGKGKEKIAQLSSRAQEIIKSWAVTMKEIISDYHQQFIYKLQDFSDQLSDYYEKFIAETERLIDLSIQKYHMFLRYIMKLLKELQSDTVNDMRPYIKVAPGEFTITF
Protein: Mitotic checkpoint protein bub-3 (Budding uninhibited by benzimidazole 3) (Q9XWH0)
Organism: Caenorhabditis elegans
Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments of chromosomes. Necessary for expression and kinetochore localization of bub-1. Plays a role in synapsis checkpoint signaling inducing apoptosis in response to unsynapsed chromosomes and thus controlling chromosomal segregation during oocyte meiosis.
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19109417, ECO:0000269|PubMed:25987605}. Nucleus {ECO:0000305}. Note=Localizes at kinetochores on condensing chromosomes in late prophase and during metaphase (PubMed:19109417). Localization to the kinetochore is dependent on bub-1 (PubMed:25987605). {ECO:0000269|PubMed:19109417, ECO:0000269|PubMed:25987605}.
Interaction partners:
- Mitotic checkpoint serine/threonine-protein kinase bub-1
- WD repeat-containing protein fzy-1
- Mitotic spindle assembly checkpoint protein MAD2A
- Cell division cycle protein 27 homolog
- BED-type domain-containing protein
- MAD related
- BUB1 N-terminal domain-containing protein
- Cell division cycle protein 23 homolog
- Cyclin N-terminal domain-containing protein
- G2/mitotic-specific cyclin-B
Sequence:
MSTYQAATIVAAPNEFRVPFPPFVQISKVQFQREAGSRLLAASGWDGTCRVYEVGKLGDISEKLVFTHGKPLLTCTFAGYNKVAFGGVDHNVKLADIETGNGTQLGSHALAVRCMEFNPMSSLIVSGGWDSSVKLWDARSYGNGAIESVNVSSSVYAMDVLKHTILVGTKDRKIFMYDSRKLREPLQVRDSPLKYQTRAVQFFPTGEAFVVSSIEGRVAVEYVDQSGEEMMKRKYAFKCHREKDTDGTELIHPVHTVAFHPKYGTFATGGADGIVNIWDPFNRKRIIQLHKFETSISSLSFNEDGSQLAIATSYQYEKEIDPSPLPNNSITIRHITDPESRPK
Protein: Elastin like protein (Q24333)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
WSSTAVAAALELVDPPGCRNSARDRQRANLNSQLYAGYPYPGVYLPQYPAYPQPAQFPAYGVLPGAVAQPGVPGVAGVPGAPGVAVVPEQLVRLLHQRHELSSLSGSQSR