wanglab/gogpt-training-data huggingface dataset:
Protein: Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) (Q6P597)
Organism: Homo sapiens (Human)
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q68G30, ECO:0000250|UniProtKB:Q91W40}. Mitochondrion {ECO:0000250|UniProtKB:Q91W40}. Note=In elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria. Also localizes to the manchette in elongating spermatids. {ECO:0000250|UniProtKB:Q68G30, ECO:0000250|UniProtKB:Q91W40}.
Interaction partners:
- Kinesin-1 heavy chain
- Kinesin heavy chain isoform 5A
- Kinesin heavy chain isoform 5C
- Kinesin light chain 1
- Kinesin light chain 2
- Kinesin light chain 4
- C-Jun-amino-terminal kinase-interacting protein 3
- Glycogen synthase kinase-3 beta
- Neurofilament light polypeptide
- Alpha-synuclein
Sequence:
MSVQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMKRAMSLNTLNVDAPRAPGTQFPSWHLDKAPRTLSASTQDLSPH
Protein: Uncharacterized protein (Q54WA6)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Cytochrome c oxidase copper chaperone
Sequence:
MDPSGHFIVDDVNGIDLSKLTIRSRVDQLTISRSSSAPPVVPEEEFQGLESISPQDPRLDINYYNYYYSQRPLDPRLPPPLITPYQAYYKNNNQQQQQQQHSFVDQDSHQHQYLPPQQQQQQQHSHPVHQQQQQQQPPQ
Protein: Uncharacterized protein (Q57YH2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Transmembrane protein
- tyrosine--tRNA ligase
- Chromosomal passenger protein
- LIM zinc-binding domain-containing protein
- Rhodanese domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- MICOS complex subunit MIC10
- Transmembrane protein
Sequence:
MSSHSSLGVAVVTGGVSLAGALVWGARWGKLRSRRADLDRQYADSLAETSALDEARLAGAELLRQKRKESVLLHEAMDSIWKDRFERYKQTNKETHSYLRALPEALGVLKGVTNHYQYMAREMRKFIGFDVACSKVHNFALLLNHGEKVGIQRVSETIRQLLVAEPLVRVVCDSLLDEATNFSCPTSISESSDSFVFCMEGLDRAVDAAAARYIELQKPSMGESPPNVFCRVLRKITTALEANMLSRCDIIMKEERQALRNHLLRDRRQLHTMHDLVGAMRYVEELSRHFQDSAKNPASVNMSVLSDPEVLLAREQLLLWRRAAAIFLVRQQAKEALNSYHLLLAETLTKTRHPS
Protein: Protocadherin 10a (Protocadherin-10a precursor) (Q6NYV7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MILIFLFFSILDGGLSQLHFSVPEEQERGTVVGNIAEDLGLDITKLSARRFQTVPSSRTPYLEVNLENGALVVNERIDREEICRQTVPCLLHLEVFLENPLELFRVEIEVMDINDNPPSFPETDITVEITESATPGTRFPVENAFDPDVGTNALSTYAITTNNYFYLDVQTQGDGNRFAELVLDKPLDREQQAIHKYVLTAVDGGQPQRTGTALLVVKVLDSNDNAPTFDQSVYSVSLRENSPVGTLVIQLNASDMDEGQNGEIVYSLSSHNSPRIRDLFNIDSRTGRIEVTGEVDYEESSTHQIYVQAKDMGPNAVPAHCKVLVKLIDVNDNTPEISFSTVTESVSEQAAPGTVIALLSVTDRDSGENGQMTCELHGEVPFKLKSSFKNYYTIVTDGPLDREKAESYTLTVVAKDKGVPSLSTSKSIKVHVSDENDNAPRFMQSVYDVYVTENNVPGAYIYAVSAVDPDVGQNAYVTYSILECEIQGMSILTYVSINSENGYLYALRSFDYEQIKEFSFMVHAKDSGAPELTANATVNVIIVDQNDNAPSVIAPLGKNGTAREHLPRSAEPGYLVTRIVATDADDGENARLSYSILRGNELGMFRMDWRTGELRTARRVSSKRDPPHPYDLLIEVRDHGQPPLSSSASINVLLVDSVVEGRSGDRGSVKSKEGSLDLTLILIIALGSVSFIFLLAMIVLAVRCQKDKKLNIYTCMAGDSCCQCCSRQARGRKKKLSKSDIMLVQSTNVASTAQVPVEESGSFGSHHQNQNYCYQVCLTPESAKTDLMFLKPCSPSRSTDTEHNPCGAIVTGYADQQPDIISNGSILSSETKHQRTELSYLVDRPRRVNSSAFQEADIVSSKDSGHGDSEQGDSDHDATNRGHTAGADLFSNCTEECKALGHSDRCWMPSFMPGDSRQGADYRSNLHVPGMDAVPDTEVQESVVPGDACNRADDRSFSTFGKDKSHHGTLTRHELHTLLPSARAPYKPNYLCEYSLKMYDF
Protein: Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) (Q45RT9)
Organism: Bifidobacterium animalis subsp. lactis (Bifidobacterium lactis)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00318}. Secreted {ECO:0000256|HAMAP-Rule:MF_00318}. Cell surface {ECO:0000256|HAMAP-Rule:MF_00318}. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. {ECO:0000256|HAMAP-Rule:MF_00318}.
Interaction partners:
Sequence:
MAVIESVXAXQXLDSRGNPTVQVVLDTEDGAQGLGLVPSGASTGEAEAWERRDGDKSVYGGKGVLNAVKAVNEVIAPKVIGMDAADQRALDDLMIELDGTPNKGKLGANAILGVSLAALYASAESAGLPLYRYIGGTNGHILPVPNMNIMNGGAHADFATDIQEYMISPYGFDTYSEALRAGVEVYHTLKNVLKKEGLNTGLGDEGGFAPKMKSNEDSLKYIMDAISAAGYEPGKQIGICLDVASSEFYNKETGKYRFDGEERDSAYMLDYYENLINEYPIVSIEDPFNEEGWEDWAAITARLGDRLQFVGDDLLVTNPARLQKAIDLGAANSLLVKLNQIGSVTETLDAIELATANGYTSMVSHRSGETPDTTISDLAVAKNTRQIKTGAPARGERVAKYNRLLEIEEELGSTAQYAGYSAXGTCKKYLAK
Protein: LEM3 (Ligand-effect modulator 3) family / CDC50 family (Q382G0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSTSGIVRRLDEGMFTVYPYHSGWIVAPILLLLSAAFVPVGVLIIKESDSLLEVSVSYGGVNKYTYRVDAEDKYPHKFSFNGSNYSTGATTAISFKINETVRQPVYMQYRVTGFFQNYRRYRSSQDYNQLLYNPRSVSQDCEPFRYPGEVHKAAETGNVYFPCGSIAWSLFNDSFKLYKGNATSTLNDSELICDGSAFDADGKSSVGHSCRKNGIASNGDIKLFRSAKEPEDEGIWSSKGKSSSDDPYRKEGYYYGEPGHRIPSVRDEDFIVWASLGYTSEVTKMYRIIEKDLEQGDYRVEIVENFDVYSFKGEKYVVLTTRSWFGEKNHEMGITFLVVGCISFVLGLGVIIQQWVL
Protein: Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (L-PGDS) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2) (P41222)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
Subcellular location: Rough endoplasmic reticulum {ECO:0000269|PubMed:9065498}. Nucleus membrane {ECO:0000269|PubMed:9065498}. Golgi apparatus {ECO:0000269|PubMed:9065498}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9065498}. Secreted {ECO:0000269|PubMed:9065498}. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
Interaction partners:
- Hematopoietic prostaglandin D synthase
- Prostaglandin E synthase
- Prostacyclin synthase
- Prostaglandin E synthase 2
- Prostaglandin G/H synthase 1
- Prostaglandin E synthase 3
- Prostaglandin G/H synthase 2
- Aldo-keto reductase family 1 member C3
- Prostaglandin D2 receptor
- Transcription factor SOX-9
Sequence:
MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ
Protein: Solute carrier family 29 member 4 (F1M2Y4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}.
Interaction partners:
Sequence:
MGSIGSQRLKEPCVAATSGQSVVTSFDNFQLETTIEGAQDPGIRVRGVPPFTDSAVDEPVPDDRYHAIYFAMLLAGVGFLLPYNSFITDVDYLHHKYPGTSIVFDMSLTYILVALAAVLLNNVVVERLNLHTRITTGYLLALGPLLFISIFDVWLQLFSHDQAYAINLAAVGTVAFGCTVQQSSFYGYTGLLPKRYTQGVMTGESTAGVMISLSRILTKLLLPDERASTIIFFLVSAGLELLCFLLHLLVRRSRFVLYYTTRPRDSRPVRAGYRVHHDVASGDIHFEHQTPALSSSRSPKDSPAHEVTHSNSGVYMRFDVPRPRVKRSWPTFRALLLHRYVVARVIWADMLSIAVTYFITLCLFPGLESEIRHCVLGEWLPILVMAVFNLSDFVGKILAALPVDWRGTHLLACSCLRVVFIPLFILCVYPTGMPALRHPAWPCVFSLLMGISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAYCTYSLTRDAHSSCFQTATANDSILVGP
Protein: Nuclear distribution protein PAC1 (Lissencephaly-1 homolog) (LIS-1) (nudF homolog) (P39946)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. Following plus end binding, dynein may be offloaded to the cortex by NUM1. Required for viability in the absence of the kinesin-related microtubule-dependent motor protein CIN8.
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to the plus ends of cytoplasmic microtubules.
Interaction partners:
- Nuclear distribution protein nudE homolog 1
- Dynein heavy chain, cytoplasmic
- Nuclear migration protein NUM1
- Nuclear fusion protein BIK1
- Nuclear migration protein JNM1
- Karyogamy protein KAR9
- Protein NIP100
- Kinesin-like protein KIP3
- Protein BIM1
- Protein PAC2
Sequence:
MTNWQQQLPLTDTQKNELDKSVLRYLNWNYKQTVRHEHAQDYESVRHAIVTLSGFLLQESVDRQEFISNNDTSNESMVDIDELLLPKKWNSIVRLQKKIIELEQNTETLVSQIKDLNTQVSELAQFKPTTSNGTSAHNVLKWIPRNLPSCLINVESSVTSVKLHPNLPIVFVATDHGKLYAFDLFNYTIPLASLQSHTKAITSMDVLFTNYTNSSKKNYLVIVTASKDLQIHVFKWVSEECKFQQIRSLLGHEHIVSAVKIWQKNNDVHIASCSRDQTVKIWDFHNGWSLKTFQPHSQWVRSIDVLGDYIISGSHDTTLRLTHWPSGNGLSVGTGHEFPIEKVKFIHFIEDSPEIRFRTPSTDRYKNWGMQYCVSASRDRTIKIWEIPLPTLMAHRAPIPNPTDSNFRCVLTLKGHLSWVRDISIRGQYLFSCADDKSVRCWDLNTGQCLHVWEKLHTGFVNCLDLDVDFDSNVTPRQMMVTGGLDCKSNVFMR
Protein: Zinc metalloproteinase-disintegrin-like botrocetin (EC 3.4.24.-) (Snake venom metalloproteinase) (SVMP) (von Willebrand factor-dependent platelet coagglutinin) [Cleaved into: Disintegrin-like botrocetin] (P22028)
Organism: Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Function: Metalloproteinase that binds to von Willebrand factor (VWF) and induces its interaction with GPIb (GP1BA), resulting in platelet aggregation.
Subcellular location: Secreted.
Interaction partners:
Sequence:
IISPPVCGNELLEEGEECDCGTPEN
Protein: Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Q9WTW7)
Organism: Rattus norvegicus (Rat)
Function: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9UHI7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UHI7}.
Interaction partners:
- Sodium-dependent nucleobase transporter 1
- Trifunctional purine biosynthetic protein adenosine-3
- Uridine monophosphate synthetase, isoform CRA_a.
Sequence:
MKAQEDPGSSKQHECPDSAGTSTRDQQAPLPAEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMISQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSMPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLRNLTFLLPVYRWGKGLTLFRIQIFKMFPIVLAIMTVWLLCYVLTLTDVLPADPTVYGFQARTDARGDIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGVCCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGVPEVDQILTVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSETLASLKSYDFPFGMGMVKRTTFFRYIPICPVFRGFSKTENQPAVLEDAPDNTETGSVCTKV
Protein: Beta1,4-N-acetylgalactosaminyltransferase A (EC 2.4.1.244) (RE56531p) (Q7KN92)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
- beta-galactoside alpha-
- Palmitoyltransferase
- Beta1,4-N-acetylgalactosaminyltransferase B
- LD27406p
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Alpha-
- Beta-1,3-galactosyltransferase brn
- Beta-1,4-mannosyltransferase egh
- Alpha1,4-galactosyltransferase 1
Sequence:
MYLFTKANLIRFLAGAICLLLVLNFVGFRSDGGSATSLSKLSIRRVHKYAHIYGNASSDGAGGSEASRLPASPLALSKDRERDQELNGGPNSTIRTVIATANFTSIPQDLTRFLLGTKKFLPPRQKSTSALLANCTDPDPRDGGPITPNTTLESLDVIEAELGPLLRPGGAFEPENCNAQHHVAIVVPFRDRYAHLLLFLRNIHPFLMKQRIAYRIFIVEQTNGKPFNRAAMMNIGYLEALKLYQWDCFIFHDVDLLPLDDRNLYNCPRQPRHMSVAIDTLNFRLPYRSIFGGVSAMTREHFQAVNGFSNSFFGWGGEDDDMSNRLKHANLFISRYPVNIARYKMLKHQKEKANPKRYENLQNGMSKIEQDGINSIKYSIYSIKQFPTFTWYLAELKNSERKS
Protein: NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) (NADH dehydrogenase subunit 5) (P11661)
Organism: Rattus norvegicus (Rat)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase 1 subunit C2
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Cytochrome c oxidase subunit 2
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
Sequence:
MNMMTSSILMILILLTTPIIISMTNLPKLIDFPSYATSSIKFSFLLSLLPLLLFFHHNTEYMITNWHWLTINSIKLTMSFKIDYFSILFLSVALFVTWSIMQFSSWYMHSDPHINRFIKYLMMFLITMLILTSANNLFQLFIGWEGVGIMSFLLIGWWYGRADANTAALQAILYNRVGDIGFILAMTWFCLNMNSWELQQIFLTNTNNLVPLTGLLIAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLMIRFHPLTSNNSTIMTAMLCLGAITTLFTAICALTQNDIKKIVAFSTSSQLGLMMVTLGINQPYLAFLHICTHAFFKAMLFMCSGSIIHSLNDEQDIRKMGNMMKAMPFTSSCLIIGSLALTGMPFLTGFYSKDLIIEAINTCNTNAWALMITLIATSMTAVYSMRIIYFVTMTKPRYSPLITINENNPNLINPIKRLALGSILAGFLISLNIPPTNIQILTMPWHLKMTALLITILGFAIALELNNLTLNLSMSKPTKLSSFSTSLGYYPPIMHRIIPQKTLNSSYKLSLNLLDLIWLEKTIPKSTSITQTQLSKMMSNQKGLIKLYFLSFLITISLIFILHTLNPEWFQ
Protein: OSBZ8 (Q40645)
Organism: Oryza sativa (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGNDEAVVTQKMGKAPSPPKDHPALSPYLDWSNMQAYYGPGILPPTFFSPGIAAGHTPPPFILGPQPLVPSAFGKPYAAIYPPGGAFSHPFMPLMVSPLSMEPAKSVNSKDSCSNKKMKEIDGATVSTGSGNSEKTSGDCSLEGSSDGNNQKASGTPKKRSIDDRPKSGVETGGALTPNDRPSEQAALPNLCIPVTAIKPDVSTASDFRVIATPVTEVPTKDDKESKRERRKQSNRESARRSRLRKQAETEELARKVELLTAENTSLRREISRLTESSKKLRLENSALMEKLTETGPDEAQEVPPVKTKAQQARGVENFLSMIDKTGTPRSSGHMDHAIATPKLRQLLGSGLATDAVAAR
Protein: Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4) (Q8BG58)
Organism: Mus musculus (Mouse)
Function: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MAAAVATVQRPEAETVEEASNLQWPLPPEHRPSGAATRPGDSEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESTDPGPQRREQSPQPVPTLGPLTRLEGIKVGYERKVQVVAGRDHFIRTLSLKPLLFEIPGFLSDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSAMQVSQLDLFQLLDQNHDGRLQLREVLAQTRLGNGRWMTPENIQEMYSAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESNELVRNSHHTWLHQGEGAHHVMRAIRQRVLRLTRLSPEIVEFSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGEVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGMDSQPEWALDRAYSDARVEL
Protein: Mediator of RNA polymerase II transcription subunit 10a (Q9FHZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 7a
- Mediator of RNA polymerase II transcription subunit 7b
- Mediator of RNA polymerase II transcription subunit 22a
- Mediator of RNA polymerase II transcription subunit 22b
Sequence:
MDQTQNTIAGIGEINGSIKTEINAIATVDDSNEKLNQIINSNQKILELLHQLKLTVSSFTPASQLHLLQRLNSLVMELDNMAKLSDKCNIQVPIEVLNLIDDGKNPDEFTKDVLNKNCIAKNQVTKGKSDAFKGLRKHLLEELEQAFPDEVDRYRDIRASYAAEAKRLAQTQSVLPNGDAKVKSEL
Protein: Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic (EC 1.2.1.13) (NADP-dependent glyceraldehydephosphate dehydrogenase A subunit 1) (P25856)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the photosynthetic reductive pentose phosphate pathway (Calvin-Benson cycle). Catalyzes the reduction of 1,3-diphosphoglycerate by NADPH (By similarity).
Subcellular location: Plastid, chloroplast membrane; Peripheral membrane protein. Plastid, chloroplast stroma.
Interaction partners:
- Phosphoribulokinase, chloroplastic
- Calvin cycle protein CP12-2, chloroplastic
- Triosephosphate isomerase, cytosolic
- Triosephosphate isomerase, chloroplastic
- Phosphoglycerate kinase 3, cytosolic
- Phosphoglycerate kinase 1, chloroplastic
- Transketolase-1, chloroplastic
- Glyceraldehyde-3-phosphate dehydrogenase GAPB, chloroplastic
- Glyceraldehyde-3-phosphate dehydrogenase GAPA2, chloroplastic
- Transketolase-2, chloroplastic
Sequence:
MASVTFSVPKGFTEFSGLRSSSASLPFGKKLSSDEFVSIVSFQTSAMGSSGGYRKGVTEAKLKVAINGFGRIGRNFLRCWHGRKDSPLDIIAINDTGGVKQASHLLKYDSTLGIFDADVKPSGETAISVDGKIIQVVSNRNPSLLPWKELGIDIVIEGTGVFVDREGAGKHIEAGAKKVIITAPGKGDIPTYVVGVNADAYSHDEPIISNASCTTNCLAPFVKVLDQKFGIIKGTMTTTHSYTGDQRLLDASHRDLRRARAAALNIVPTSTGAAKAVALVLPNLKGKLNGIALRVPTPNVSVVDLVVQVSKKTFAEEVNAAFRDSAEKELKGILDVCDEPLVSVDFRCSDFSTTIDSSLTMVMGDDMVKVIAWYDNEWGYSQRVVDLADIVANNWK
Protein: Phosphorelay intermediate protein YPD1 (Q59WC6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Phosphorelay intermediate protein that is part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to oxidative stress and probably to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound histidine kinase SLN1 to two distinct response regulators SSK1 and SKN7.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Histidine protein kinase SLN1
- Transcription factor SKN7
- Oxidative stress response two-component system protein SSK1
- Mitogen-activated protein kinase HOG1
- mitogen-activated protein kinase kinase
- MAP kinase kinase kinase
- High osmolarity signaling protein SHO1
- Histidine protein kinase NIK1
- mitogen-activated protein kinase kinase kinase
- Ste50p
Sequence:
MSEDKLQKLQDSGLVDWAVFSEIVTMDEDEEGFSKSLVEVFVSQVEETFEEIDKYLKEKNLEKLSSSGHFLKGSAAALGLTKISNQCERIQNYGHKINFDNFQLEDIKTKGDSAVSAENVAVNDGETNPENGSNGNETSNNKTNTSNIPDESSDDFWIALIEDALAKARDGFDQSRRALDEYYE
Protein: Retinoblastoma 1 (Retinoblastoma-associated protein) (A0JMQ4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPPKKRSSGTPQKKELKGSLKSRSPDSGDNAVLSPERHKDKDPEFVFLSEELQSTNSICDHAWRIWEREIRSMDKTNMPYSNRQQWGACLFIAGMELEGINLTFTQFLKAVGLSVKQFISLVRKMDVNVDTISPKVNSAVTRLENKYDVTLALYQRFVKTCEKIFAEPDNAKRKELWESSWTMFLLAKGTFLQMEDDLVISFQLLLCVLEFFAKRLSPSLLQSPYNSVVSSSTLSPPTRTSRRNQGKSKPRPAEMDMQLLETLCKEGDCSVDEVKNVYQSTFCAFLDSVGLLGLQGLPPMEALSKQYEELYHKSKDFDARLFLSDDETLSPNKIEVSKVEVTPRKNLFAEDIAIPVPQTPIRAAMTSIQQLRGDLTSGSDQPSSNLLVYYKNCTVDPSGEIKKRVEELGEVFIQRFAQAVGQHCEGLGRKRFYLGAQLYYKVMESMLKSEEKRLSVQNFSKLLNNAAFHTSLLACALEVVIATYVGSSLKNGGFGRSSGASDSVESDLCFPWILSVFQLPAFDFYKVIESFIKAEPTLKHDMVKHLEQCEHVIMESLAWRTDSPLFDLLKQSREEGPGEQAEPPATLNQPLHHNHTAADLYLSPVRPCRQPPVMEAEPPTPGTRAPRSNSLSLFYKKLYRMAYLRLKMLFSNLLTSHPEMEPIIWTLLQHTLQNEYELMRDRHLDQLIMSAMYAICKVKNVDLRFKTIVTAYKELPNTNQETFKRVLIREGQYDSIIVFYNLVFMQKLKTNILQYSSPRPPPLSPIPHIPCSPYKNSPLRVPGSNNVYVSPLKSSRVSPLVMTPRSRILISIGESFGSADKFQKINQMLSSSDWSLKRSLDGGSAPKPLKRLRFDMDGQDEADGSKSSGESALIQKLAEMSSTRSRMQEQKLKEESDKDHPEP
Protein: Tropomyosin 1 (cDNA FLJ16459 fis, clone BRCAN2002473, moderately similar to Tropomyosin, fibroblast isoform 2) (Q6ZN40)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM
Protein: Histidine/lysine/arginine/ornithine transport system permease protein HisM (P0AEU3)
Organism: Escherichia coli (strain K12)
Function: Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP
- Histidine-binding periplasmic protein
- Lysine/arginine/ornithine-binding periplasmic protein
- Histidine/lysine/arginine/ornithine transport system permease protein HisQ
- Putative ABC transporter arginine-binding protein 2
- ABC transporter arginine-binding protein 1
- L-cystine-binding protein TcyJ
- Glutamine-binding periplasmic protein
- Glutamate/aspartate import ATP-binding protein GltL
- Arginine transport ATP-binding protein ArtP
Sequence:
MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKPSSTH