Protein: Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) (Q9WTI7)
Organism: Mus musculus (Mouse)
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11030652, ECO:0000269|PubMed:12490950, ECO:0000269|PubMed:16492791}. Nucleus {ECO:0000250|UniProtKB:O00159}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12490950, ECO:0000269|PubMed:16492791, ECO:0000269|PubMed:17994197}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q92002}. Cytoplasmic vesicle {ECO:0000269|PubMed:22918957}. Cell projection, ruffle membrane {ECO:0000269|PubMed:17994197, ECO:0000269|PubMed:22918957}. Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane (PubMed:17994197). Colocalizes in adipocytes with GLUT4 at actin-based membranes (PubMed:12490950). Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane (PubMed:22918957). Localizes transiently at cell membrane to region known to be enriched in PIP2 (PubMed:16492791). Activation of phospholipase C results in its redistribution to the cytoplasm (PubMed:16492791). Colocalizes with RNA polymerase II (By similarity). Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription (By similarity). {ECO:0000250|UniProtKB:O00159, ECO:0000269|PubMed:12490950, ECO:0000269|PubMed:16492791, ECO:0000269|PubMed:17994197, ECO:0000269|PubMed:22918957}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleolus {ECO:0000269|PubMed:11030652, ECO:0000269|PubMed:16514417, ECO:0000305|PubMed:16957816}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16514417}. Note=Colocalizes with RNA polymerase II in the nucleus (PubMed:11030652). Colocalizes with RNA polymerase I in nucleoli (PubMed:16514417). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC) (By similarity). Accumulates strongly in DFC and GC during activation of transcription (By similarity). Colocalizes with transcription sites (PubMed:16514417). Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6 (By similarity). Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles (By similarity). Colocalizes with RPS6 at the nuclear pore level (By similarity). {ECO:0000250|UniProtKB:O00159, ECO:0000269|PubMed:11030652, ECO:0000269|PubMed:16514417}.
Interaction partners:
- Calmodulin-1
- Actin, cytoplasmic 2
- EF-hand domain-containing protein
- Myosin-IIIa
- F-actin-uncapping protein LRRC16A
- Myosin-9
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- Unconventional myosin-VI
- Moesin
- Tyrosine-protein kinase BAZ1B
Sequence:
MALQVELIPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHVFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVMRKALSVIDFTEDEVEDLLSIVASVLHLGNIHFAADEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKPHPHFLTHKLADQKTRKSLDRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSMNPIMAQCFDKSELSDKKRPETVATQFKMSLLQLVEILRSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPMWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFILRHSPRCPENAFFLDHVRASFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTEEISPRVLQSLGSEPIQYAVPVVKYDRKGYKPRPRQLLLTPSAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQREDNKQKGDVVLQSDHVIETLTKTALSADRVNNININQGSITFAGGPGRDGIIDFTSGSELLITKAKNGHLAVVAPRLNSR