wanglab/gogpt-training-data huggingface dataset:
Protein: Adiponectin (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte, C1q and collagen domain-containing protein) (Adipocyte-specific protein AdipoQ) (Q60994)
Organism: Mus musculus (Mouse)
Function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Subcellular location: Secreted {ECO:0000269|PubMed:23209641}.
Interaction partners:
- Adiponectin receptor protein 2
- Adiponectin receptor protein 1
- Cadherin-13
- Complement factor D
- Leptin
- Resistin
- Insulin-2
- Insulin-1
- Fatty acid-binding protein, adipocyte
- Resistin-like gamma
Sequence:
MLLLQALLFLLILPSHAEDDVTTTEELAPALVPPPKGTCAGWMAGIPGHPGHNGTPGRDGRDGTPGEKGEKGDAGLLGPKGETGDVGMTGAEGPRGFPGTPGRKGEPGEAAYVYRSAFSVGLETRVTVPNVPIRFTKIFYNQQNHYDGSTGKFYCNIPGLYYFSYHITVYMKDVKVSLFKKDKAVLFTYDQYQEKNVDQASGSVLLHLEVGDQVWLQVYGDGDHNGLYADNVNDSTFTGFLLYHDTN
Protein: SNARE-like superfamily protein (F4HTY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Trafficking protein particle complex II-specific subunit 120 homolog
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit 2-like protein
- Trafficking protein particle complex II-specific subunit 130 homolog
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Tetratricopeptide repeat
- Transport protein particle
- Trafficking protein particle complex subunit-like protein
Sequence:
MANTACFIIVGRNDIPIYEAEVGSAAKREDAAQLHQFILHAALDVVQDLAWTTSAMFLKSVDRFNDLVVSVYVTAGHTRLMLLHDSRNEDGIKSFFQEVHELYIKILLNPLYLPGSRITSSHFDTKVRALARKYL
Protein: SNAP receptor (A0A1D8PK25)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Synaptobrevin homolog YKT6
- V-SNARE protein
- Syntaxin
- Uncharacterized protein
- Protein transport protein SEC22
- Vam7p
- Vesicular-fusion protein SEC18
- Vacuolar protein sorting-associated protein 41
- SNAP receptor
- E3 ubiquitin-protein ligase PEP5
Sequence:
MSFANIDLEAQKEPLLKGKENDANYTSPDELDTIIGKTSRQLSVFGNLISQFETQRKQIGTRRDTQELRNTIDVLTGKIQEMDRAISALIANLSTLINSKNSITASASISNRHIVIEERLSRQYSELSKAFNKSTKVYQEKKRTTPLLTRPSKETEEQTKSEDTLATSQQEQEQVQTQVDQDLIDQTELQYHILLTEERNREIEQVTEGIMEVNSIFKDLSQLVHQQGEQVNTIEDNILQLHGNTQQASNELNKANEYQKQKGKWSCILLVALCIFLLVIVLIVVS
Protein: Protein kinase C, eye isozyme (EC 2.7.11.13) (Eye-PKC) (Inactivation no after-potential C protein) (Protein INAC) (Photoreceptor-specific PKC) (dPKC53E(EY)) (P13677)
Organism: Drosophila melanogaster (Fruit fly)
Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection.
Interaction partners:
- Inactivation-no-after-potential D protein
- Transient receptor potential protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Opsin Rh1
- Neither inactivation nor afterpotential protein C
- Transient-receptor-potential-like protein
- G protein alpha q subunit subunit alpha)
- Serine/threonine-protein kinase mTor
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
- Protein kinase C, brain isozyme
Sequence:
MAAAAVATPGATVLPPSVPSAAPGAKAPAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFITII
Protein: Voltage-dependent L-type calcium channel subunit alpha (Q923Z7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
Interaction partners:
Sequence:
MSESEVGKDTTPEPSPANGTGPGPEWGLCPGPPTVGTDTSGASGLGTPRRRTQHNKHKTVVVASAQRSPRALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTATHNLEQVEYVFLVIFTVKTVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRSCTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELDLHDPSVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSITDTPGDEDEEEGTMASCTLCLNKIMKTKVCRHFRRANRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLASGDAGAAKDKGREKSSEGNPPQENKVLVPGGENEDTEGTKSEGAAPGMEEEEEEEEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHVFTSLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHQGSFCRSWFNLLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAHAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYFADAWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPHVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLRIKTEGNLDQANQELRMVIKKIWKRIKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGADAPTSTSSVLQAGLRSLQDLGPEIRQALTYALEEEEEEEEARQVKEAEEEEAETTPETYKDSIDSQPQAQWNSRISVSLPKLRETPDSLSTGPSDDDGVAPNSRQPSGLQAGSQPHRRGSGVFMFTIPEEGSTQLKGVQGQDNQNEEQEVPDWTPNLDEQAGMPSNPVLLPPHWSQQHVNGHHVPRRRLLPPTPAGRKPSFTIQCLQRQGSCEDLPIPGTYHRGRTSGPGRAQGSWAAPPQKGRLLYAPLLLVEESTVGEGYLGKLGGPLRTFTCLQVPGAPSDPSHRKRGSADSLVEAVLISEGLGLFAQDPRFVALAKQEIADACHLTLDEMDSAASDLLAQRTTSLYSDEESILSRFDEEDLGDEMACVHAL
Protein: Dhps protein (Q567L8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MIEKRLEPVQEECEDSDSRQSASGCTIFLGYTSNLISSGVRESIRYLTQHKMVDVIVTAAGGIEEDLIKCLAPTFLGEFSLKGMELRQQGINRMGNLLVPNENYCKFEDWLMPILDQMVLEQKTEGTHWTPSKMIHRLGKEINNPDSVYYWAYKSDIPVFSPALTDGSLGDMIYFHSYKNPGLVLDIVEDIRRLNSKAVFAKSTGMIILGGGLVKHHIANANLMRNGADFAVFVNTGQEFDGSDSGARPDEAISWGKIRMDASPVKVYADASLVFPLLVAETFAHNASRLIQEKESD
Protein: T-box transcription factor TBX20 (T-box protein 20) (H15-related T-box transcription factor hrT) (Q9I9K7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Interaction partners:
- NK2 homeobox 5.
- GATA-binding protein 4.
- Heart- and neural crest derivatives-expressed protein 2
- Homeobox protein goosecoid
- Insulin gene enhancer protein isl-1
- Homeobox protein Meis1b
- GATA-binding protein 6
- GATA-binding protein 5
- Neurogenic locus notch homolog protein 1
- Myocyte enhancer factor 2ca
Sequence:
MEYTSSPKPQLSSRANAFSIAALMSSGKTKDKESEENTIKPLEQFVEKSSCHPNLGDLPPLETHSDFSSGGGTGSGAPLCTEPLIPTTPGVPSEEMAKISCSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFVFTETVFTAVTAYQNQLITRLKIDSNPFAKGFRDSSRLTDIERESVESLIHKHSYARSPIRTYAGDEETLGEEGHSAHSRGSAFTASDNLSLSSWVTTTSGFSGFQHPQSLSAIGTSTASLASPLPHPIQGSLPPYSRLGMPLTPSALASSMQATGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSTVMTPFV
Protein: Sugar ABC transporter, permease protein (Q5LSE7)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}.
Interaction partners:
- Sugar ABC transporter, permease protein
- Sugar ABC transporter, periplasmic sugar-binding protein
- Sugar ABC transporter, ATP-binding protein
- Sugar ABC transporter, permease protein
- sn-glycerol-3-phosphate transport system permease protein UgpA
- sn-glycerol-3-phosphate import ATP-binding protein UgpC
- Sugar ABC transporter, ATP-binding protein
- Sugar ABC transporter, permease protein
- Sugar ABC transporter, ATP-binding protein
- Sugar ABC transporter, ATP-binding protein
Sequence:
MRPAVFNYTMAFTQAPLLRYLLNGVIVTVSIFVIQVAVALPAAYALAKLRFWGREAVFGLVLFCLLIPVHAIALPLYILLAKLGLTNTYAALVVPWTISVFGIFLMRQFFMTVPDDLIDAARMDGMSEFAIVWRVMLPTAIPALLAFAIFSVVAHWNDYFWPRIVVTGNRDLFTPPLGLREFKGDGDGSFFGPMMATATVIVAPLIVAFLLAQRRFIEGITLSGMK
Protein: Solute carrier family 22 member 7 (Novel liver transporter) (NLT) (Organic anion transporter 2) (hOAT2) (Q9Y694)
Organism: Homo sapiens (Human)
Function: Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2-alpha, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.
Subcellular location: [Isoform 2]: Basolateral cell membrane {ECO:0000269|PubMed:12023506, ECO:0000269|PubMed:25904762}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:25904762}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:18216183}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral side of the proximal tubules (PubMed:12023506, PubMed:25904762). Apical side of the renal tubule (PubMed:25904762). {ECO:0000269|PubMed:12023506, ECO:0000269|PubMed:25904762}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:18216183}.
Interaction partners:
- Solute carrier organic anion transporter family member 1B1
- Solute carrier organic anion transporter family member 1B3
- Organic anion transporter 3
- Solute carrier organic anion transporter family member 1A2
- ATP-binding cassette sub-family C member 4
- Solute carrier organic anion transporter family member 2B1
- Hepatic sodium/bile acid cotransporter
- Multidrug and toxin extrusion protein 1
- Multidrug and toxin extrusion protein 2
Sequence:
MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEEMPMKQVQN
Protein: Anastral spindle 2, isoform B (A0A0B4LFU9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MFVPETEDMLPRLAPRPSAAVPMGHTNEIIGPTVPEVSILFGQPPQDPQMQPQQPNHAHQESSPRAAPTFASWKKQMLPRVNFSPILATELGPRTAPSSNSPCSSKEYQVMPRDRNYASDAQQTTNHMNCNAGGYNAEPKQQAYQSRRLSSSSNADVLTICAGTQTDPFNPSPPRKSLPQVVYSDIDVSNLANKSDLAALVSLVESVRHEQQQLRNLCEMILEQQQRAKPEAISKASSTTGTQCDILTTNQGRRLSPIMQDYIAEEEEPLPPPQARVIPQFPSPRPHPPIAQSTGYRANTPQAKRIPQLAKPNTEKSMVMNELALKYLRQPVDELMKDMRLGASPKSPNPEPLRPIDNIGHAQSPNDISNASYKYLKKYRLLPEEQLEPVCPQSPMAATAPSPHIQLDLENIRNQPKLL
Protein: Down syndrome cell adhesion molecule 1, isoform CD (A0A0B4KEF4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVSQHYEEDIHKAFVIRGNSAILKCDIPSFVADFVNVISWHSDEKENFYPGTEYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVGPKLTSGDDSRTVRIRQEDSVTLLCPAQAYPVPVYRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPRIIPFAFEEGPAQVGQYLTLHCSVPGGDLPLNIDWTLDGQAISEDLGITTSRVGRRGSVLTIEAVEASHAGNFTCHARNLAGHQQFTTPLNVYVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPSRDLPELSAEDTIRIILSNLNLVVPVVAALLVIIIAIIVICILRSKGNHHKVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGTVISMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGETKPAQNNSNSNKQMAQDSQPTILWQCNL
Protein: NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) (SbCPR) (C5YJG8)
Organism: Sorghum bicolor (Sorghum) (Sorghum vulgare)
Function: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03212}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03212}.
Interaction partners:
- assimilatory sulfite reductase
- Ferredoxin--nitrite reductase, chloroplastic
- Adenosine 5'-phosphosulfate reductase
- Anamorsin homolog
- FAD synthase
Sequence:
MDSATTSGAMELVAALLRGRVPPELMGGDGAEGRALVATLAAAVLGAALFVLWRRAAAGKKRKREAAAAAVAEATEVKARAAKGGEDEKAADDGRKKVTVFFGTQTGTAEGFAKALAEEAKARYDKAIFKVVDLDDYAAEDEEYEEKLKKEKLALFFVATYGDGEPTDNAARFYKWFTEGNERGVWLNDFEYAVFGLGNRQYEHFNKVAKVVDEILTEQGGKRLVPVGLGDDDQCIEDDFNAWKEALWPELDRLLRDENDASTGTTYTAAIPEYRVEFIKPEEAAHLERNFSLANGHAVHDAQHPCQANVAVRRELHTPASDRSCTHLEFDIAGTGLTYETGDHVGVYTENCPEVVEEAERLLGYSPDTFFTIHADKEDGTPLSGSSLAPPFPSPITVRNALARYADLLNSPKKTSLVALATYASDPAEADRLRFLASAAGKDEYAQWVVASQRSLLEVMAEFPSAKPPLGVFFAAVAPRLQPRYYSISSSPSMAATRIHVTCALVHETTPAGRVHKGVCSTWIKNAVPSEESKDCSWAPIFVRQSNFKLPADPSVPIIMIGPGTGLAPFRGFLQERLAQKESGAELGPSVFFFGCRNSKMDFIYEDELNNFLEQGALSELVLAFSRQGPTKEYVQHKMAQKASEIWDMISQGAYIYVCGDAKGMARDVHRVLHTIVQEQGSLDSSKAESFVKNLQMEGRYLRDVW
Protein: Ephexin, isoform D (Ephexin, isoform E) (FI17855p1) (Q9VVC6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ras-like GTP-binding protein Rho1
- Tyrosine-protein kinase Src64B
Sequence:
MAMSPVLDAAAKAAGRDLNGNSNAASATAASTATPTAAAAAAATTPRKTKKTIINWLVNSDSENNNRATCDKAGKDNPNPNQNPNSQANPNQNCSCESRAFRDFRGVQTLRLLWSRRIKSASEDQCHSPVHCHTSSSSLGTLKKLNKSVSCLVNAFNNSRDCATPEKTLAKRAASLHNLQDSQAKHKQLHREKDNFYKYKNAEQAKMQAKLRSSADEAILNASETRAKRDDSGCLPGVKSYNSKALSAADKVAKVAKGEAKTQRRAEEPVGEAEVEVEVEFRAKREHNRLEGLSLSAASAQSGGSSESLQTTTTSSSTPTTHSSVTSSTGRSGGRRKYSFKTHAGKSYHQHHHPSRRTSNMDSSNGGISMVAKLTHQFNEIIQKDAKLLEQVKRNNGVWISRGTHVYKIVEKPTSEGKGLPNADDNRISTVQRNIKKFERLEKPSVPLKSEQLMRKHLELMRGSSLSRGPRIKRNLKLPPGSVGIPELAIVSEELKTPTSEEQAKKPKSVQNESQPNHPEELNQSNDKPSDELDLIMGEEGDEEELRQKQRKHKYASIYEKLRFTFAKGRKSASPSPTKAQIREEVSIDEESIKDSTSEDMVTRKEDFTLDLPKEVIPRAEDLEDSSHALLVSPCFEADAKILDALEAVDLKLKVLNPLNDVTTADGERELLLAANDDFEQRILPNSSFVYQAANKQYSNNQILLNQAVNVTLVNAIEGEQMIMEQKQLMKVRDLELTERDIDQPLKRAEKSPEKDDTLEPESLYEPITPVMDETKTEAQTSSLFKIYTKKSELVEDIYQTVEEASTVEVKPNNWLEGYESIAGSQEACPLTYDGYESFAPEEVVTTPTTPSATGTLGRNTRDELPELPKPKRVLNKSPIPLRPAPPKPQAKESEEDENIYDTIKGCYESMHCKATSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCRSSLGSSAGSRDSGKPGDKRSSIAGSSDNSDAWVDISDGEIGQATTDATANEAQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLGNKRHSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLRQRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTDFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRLLTFTATYLESQKSK
Protein: Potassium channel toxin alpha-KTx 13.1 (Toxin Tc1) (Toxin To1) (P83243)
Organism: Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Function: Blocks reversibly Shaker B potassium channels. Also displaces binding of noxiustoxin to mouse brain synaptosome membranes.
Subcellular location: Secreted {ECO:0000269|PubMed:15025998, ECO:0000305}.
Interaction partners:
Sequence:
ACGSCRKKCKGSGKCINGRCKCY
Protein: YY1-associated factor 2 (Q8IY57)
Organism: Homo sapiens (Human)
Function: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.
Subcellular location: Nucleus {ECO:0000269|PubMed:11593398}.
Interaction partners:
- Polycomb group RING finger protein 1
- Polycomb group RING finger protein 6
- E3 ubiquitin-protein ligase RING1
- E3 ubiquitin-protein ligase RING2
- RING1 and YY1-binding protein
- Lysine-specific demethylase 2B
- Polycomb group RING finger protein 5
- Lethal
- Polycomb complex protein BMI-1
- Polycomb group RING finger protein 3
Sequence:
MGDKKSPTRPKRQPKPSSDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRKPRPVSQLVAQQVTQQFVPPTQSKKEKKDKVEKEKSEKETTSKKNSHKKTRPRLKNVDRSSAQHLEVTVGDLTVIITDFKEKTKSPPASSAASADQHSQSGSSSDNTERGMSRSSSPRGEASSLNGESH
Protein: Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like (H0Y327)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFKPVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSVGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRGQTP
Protein: Transcriptional regulator STERILE APETALA (Q9FKH1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator involved in the specification of floral identity. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in the external flower organs in association with APETALA2 and other repressors. Is required to maintain floral meristem identity in concert with AGAMOUS. Interacts also with APETALA2 to ensure the normal development of ovule.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein TIFY 4A
- Beta-galactosidase related protein
- Protein TIFY 4B
Sequence:
MSTSSSSSDNGAGGSGGVFEAPSPSRPRRGANDVWPEPFLESLAVQVAVNASTSAGLLAAAPALANVFRVCTTWHAVSRSDHLWQLLSRQVWARTHLMHDTWRDEFIYRHRTARNFRTRTHTYFTLQFDPSDVDEPDSLSCRCLTLSDLYLAAGFADGTVRLFLLNNRLHVRTLRPPLRDRFGRFSRAVSGIVISDSRLTFATMDGDIHVAEIDGVGHTRTAYAGDIVNDGALVDFTGCGRWWVGLFAGVPGRAFHIWDCNSEETTFVGGTLTDPEAVMGWHTLTELTTSLGRLRISGNETAVACTRWRIMVIDLRNQGVIIGEDEEQRRGLIVTGFDANDEAYVRLDSRGNASVRRVNTQQTVCEFRVSGAAQRRVMGCVNRLHALMCAGGIMRVWEVERGEYLYSIRERVGEVDAIVADDRHVAVASASSTAQSIIHLWDFGAL
Protein: Carboxy-S-adenosyl-L-methionine synthase (Cx-SAM synthase) (EC 2.1.3.-) (P76290)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
Interaction partners:
- tRNA U34 carboxymethyltransferase
- tRNA 5-carboxymethoxyuridine methyltransferase
- Inner membrane protein YecN
- tRNA1
- tRNA
- Thiazole synthase
Sequence:
MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCKIIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHNAGFEHSELWFQCFNFGSLVALKAEDAA
Protein: Uncharacterized protein, isoform B (Uncharacterized protein, isoform C) (Uncharacterized protein, isoform D) (Uncharacterized protein, isoform E) (Q9VR83)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- IP11023p
Sequence:
MCNSWLVLIIALSVVVCLWNSQQTETSKSCPAECICLSQTQVLCNTGGLEQIPLRQLPATVENLALTKNNFPIIKPDSFAGLRALKKLSLDGNNITRIKQFAFRGLPRLKELSIQYTPLQMVAQFAFAGLQNLSTILLSHNQIQRIEGNAFAGTSNIKLILLTNNPLIRIDSSAFSSLTNVGHLILPSGIRSIEQDAFFGMDTVGLLKLAYMDLKEVAPFTFRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQILNNKIDSIEELNFTSTAAIKHLKFFGNHVLETPDPNSIIVDGVEHLQLVSNHFPCGCHIHTLLDGPLAEGAHNLTDFLQKNYCISPLEVNGRVMSELDIDSIGRCSDQLTKGNLGSSAASLALGINSMLLIAVASCAEWRHVRLLANRLAQLLGHVAWRRRRKRRKGN
Protein: Regulatory protein zeste (A0A0B4KEQ7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00371}.
Interaction partners:
- DNA polymerase zeta subunit 2
- Kelch-like protein diablo
- Uncharacterized protein, isoform A
Sequence:
MDRVTKPQKKMLITLLRETKYMEGKKEKEWYWEKIQAALNTIGPKKTIIQWKKCWRDMRLTTRKKLAELKRCQLSGGSPPPGIELNQEDNDIIDIVGTEYFYEEMNGELKAENFLTGLDYAPEHLCDAILTAAVGHHQHNMQHQKDPQSHAGQQQQQDHHTNDGETNDAPGSSNGGSYQGHPVSQLQAHNGSGGGGEHSGGGQSHSGMLQHPAFHGGLHPHLLRRQHGSGSLSRESPFEEKLLQFMQDAFPKKSKKRKNRDPDKLFLLSLYEEIKRVPEEIRLDVKSELMQILKKYQKKSPVKAEKPAPSSTSTSSKLSSSSSGSSTVTTHLSHSMYQLQKKYEKGEREPSPQSQVERVASAGAVAVPIHTSQQLPLFQLQKKYEENSVEKVHQQQQQQQSEQRKHVEAAQALHAAHQQPPPPPPNEHLHHPQMAHNIMFPLGQLRNEQPTAQQHQHGHNPHQQQQQHPHQQQQQGQQHHPPTIFGSTASERPPMSYENVGXVLSRLWEATCGAPRPATVSPTTADAHSC
Protein: Superoxide dismutase copper/zinc binding domain-containing protein (G8BEG8)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- Superoxide dismutase 1 copper chaperone
- Superoxide dismutase
- Catalase
- Catalase
Sequence:
MVSYSILSVLALASVAIAGDTPIQSDSADQPSLQAKFEKSEKSDITGTITFEPANNGSVLVKVDVEGLPSSGGPFPYHIHERPVPADGNCTGTKMHLNPYGGNENATTPQGLEAGDLSGRHGKIQGTSLSTEYVDNYISLNPDSKTYFGDLSIVIHFANTSRITCSNLTELESNGGGSNSTSSSEAGVSTANGAGNLQTGGLLAGALAGAAALLI