wanglab/gogpt-training-data huggingface dataset:
Protein: Perlecan domain V (Q9NFS9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
TGAIPQFRQEPRSYMSFPTLPNSSFKFNFELTFRPENGDGLLLFNGQTRGSGDYIALSLKDRYAEFRFDFGGKPMLVRAEEPLALNEWHTVRVSRFKRDGYIQVDEQHPVAFPTLQQIPQLDLIEDLYIGGVPNWELLPADAVSQQVGFVGCISRLTLQGRTVELIREAKYKEGITDCRPCAQGPCQNKGVCLESQTEQAYTCICQPGWTGRDCAIEGTQCTPGVCGAGRCENTENDMECLCPLNRSGDRCQYNEILNEHSLNFKGNSFAAYGTPKVTKVNITLSVRPASLEDSVILYTAESTLPSGDYLALVLRGGHAELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGEGILRVGDGPERKAKAPGSDRILSLKTHLYVGGYDRSTVKVNRDVNITKGFDGCISRLYNFQKPVNLLADIKDAANIQSCGETNMIGGDEDSDNEPPVPPPTPDVHENELQPYAMAPCASDPCENGGSCSEQEDVAVCSCPFGFSGKHCQEHLQLGFNASFRGDGYVELNRSHFQPALEQSYTSMGIVFTTNKPNGLLFWWGQEAGEEYTGQDFIAAAVVDGYVEYSMRLDGEEAVIRNSDIRVDNGERHIVIAKRDENTAILEVDRMLHSGETRPTSKKSMKLPGNVFVGGAPDLEVFTGFRYKHNLNGCIVVVEGETVGQINLSSAAVNGVNANVCPANDDPLGGTEPPVV
Protein: Nuclear nucleic acid-binding protein C1D (Q9VXL4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU368003}. Nucleus, nucleolus {ECO:0000256|RuleBase:RU368003}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368003}.
Interaction partners:
- Exosome complex component 10 homolog
- FI06805p
- Csl4
- Exosome complex component RRP45
- Ribosomal RNA-processing protein 42
- Exosome complex component RRP4
- Exosome complex exonuclease RRP44
- FI07225p
- FI01414p
- RNA helicase
Sequence:
MAQENQAVDNGLPCNAYLDTSLREDENMQHILKTFYSSIELLEADTEKALALQAERTLNTNEQIKLDSYLVYLNSTLFFIYLKLQGEDASNHAVMHDLRRTRDLLARDKKINDALAAPRLDMPAAKRFIAAGTHTRFVDMNGVMVSEKQYNKSKQETPK
Protein: Probable PhiRv1 phage protein (O06614)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Virion {ECO:0000256|ARBA:ARBA00004328}.
Interaction partners:
- Probable PhiRv1 phage protein
- Possible PhiRv2 prophage protease
- Probable PhiRv1 integrase
- Possible PhiRv2 prophage protein
- Possible oxidoreductase
- Encapsulin nanocompartment protein Rv1762c
- Sphingomyelinase
- PPE family protein PPE8
Sequence:
MTEFDDIKNLSLPETRDAAKQLLDSVAGDLTGEAAQRFQALTRHAEELRAEQRRRGREAEEALRRYRAGELRVVPGAPTGGDDGDAPPGNSLRDTAFRTLDSCVRDGLMSSRAAETAETLCRTGPPQSTSWAQRWLAATGSRDYLGAFVKRVSNPVAGHTVWTDREAAAWREAAAVAAEQRAMGLVDTQGGFLIPAALDPAILLSGDGSTNPIRQVARVVQTTSEIWRGVTSEGAEARWYSEAQEVSDDSPALAQPAVPNYRGSCWIPFSIELEGDAASFVGEIGKILADSVEQLQAAAFVNGSGNGEPTGFVSALTGTSDQVVVGAGSEAIVAADVYALQSALPPRFQASAAFAANLSTINTLRQAETSNGALKFPSLHDSPPMLAGKSVLEVSHMDTVDSAVTATNHPLVLGDWKQFLIGDRVGSMVELVPHLFGPNRRPTGQRGFFAWFRVGSDVLVRNAFRVLKVETTA
Protein: LppP/LprE family lipoprotein (O06346)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MSDEIDPDWPAPAYQPSDDVDTTPPAPGGSWPTAWLVALVVLACVAAAVVAYAGMHRVRPGANQAAPATTSAPARPTSPASQVGPCGPDEATAVRAALAQLAPDSKTGRPWNSTPEDSNYDPCADLSAVLVTVQDATNSSPDQALMFHRGTFVGTATPRAYPFTNLIGPASTNDIVVLSYRTRQSCDGCQDGILTIVGFAWRGDHVQILDSLPELFDAPP
Protein: Phosphodiesterase (EC 3.1.4.-) (A0A8I6AJW4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGCAPSIHVSQSGVIYCRDSDESNSPRQTSSVSQGPTAPLHGLFVQTDAADAMPPSRAAGPPGAVRVRRSRAELGSGSSTGSSGPAATTCRGRRRHCCSSAEAETQTSYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTRNFDAEAVCRSIRATNPSEHTVILAVVSQASDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQIHRIHRDSGDNSQTEPHSFRHKSRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHHSHSHLSMPITINDVPPSIAQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAAESEGSDCECNPTGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSNS
Protein: Transcription factor Jun (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (P18870)
Organism: Gallus gallus (Chicken)
Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter.
Subcellular location: Nucleus.
Interaction partners:
- Protein c-Fos
- Mitogen-activated protein kinase 9
- Stress-activated protein kinase JNK
- Activating transcription factor 3
- Mitogen-activated protein kinase.
- FosB proto-oncogene, AP-1 transcription factor subunit.
- Fos-related antigen 2
- Cyclic AMP-dependent transcription factor ATF-2
- Mitogen-activated protein kinase.
- Mitogen-activated protein kinase.
Sequence:
MSAKMEPTFYEDALNASFAPPESGGYGYNNAKVLKQSMTLNLSDAASSLKPHLRNKNADILTSPDVGLLKLASPELERLIIQSSNGLITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHNQNTLPSVTSAAQPVSGGMAPVSSMAGGGSFNTSLHSEPPVYANLSNFNPNALNSAPNYNANGMGYAPQHHINPQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Protein: Peptidyl-tRNA hydrolase (Pth) (EC 3.1.1.29) [Cleaved into: Peptidyl-tRNA hydrolase, N-terminally processed] (P0A7D1)
Organism: Escherichia coli (strain K12)
Function: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00083, ECO:0000305|PubMed:4898482, ECO:0000305|PubMed:9303320}.
Interaction partners:
- Ribosome-binding ATPase YchF
- Deoxyribodipyrimidine photo-lyase
- Peptidyl-tRNA hydrolase ArfB
- Ribosome-recycling factor
- Peptide chain release factor RF1
- D-serine dehydratase
- Peptide chain release factor RF2
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Sequence:
MTIKLIVGLANPGAEYAATRHNAGAWFVDLLAERLRAPLREEAKFFGYTSRVTLGGEDVRLLVPTTFMNLSGKAVAAMASFFRINPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRIGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTEMWFTDGLTKATNRLHAFKAQ
Protein: L-gulonolactone oxidase 2 (AtGulLO2) (EC 1.1.3.8) (Q6NQ66)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the oxidation of L-gulono-1,4-lactone to ascorbic acid. L-gulono-1,4-lactone is oxidized to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate (By similarity).
Interaction partners:
- L-galactono-1,4-lactone dehydrogenase, mitochondrial
- L-galactose dehydrogenase
- Monodehydroascorbate reductase 3
- GDP-mannose 3,5-epimerase
- Putative F-box protein At1g65770
- Ubiquitin carboxyl-terminal hydrolase 25
- Glutathione S-transferase DHAR2
- Mannose-1-phosphate guanylyltransferase 1
- GDP-L-galactose phosphorylase 1
- Phosphomannomutase
Sequence:
MAFTFPPSYRTLVGLYYIFTLMHTAVSTPPDDPVKCVSGNTNCTVTNSYGAFPDRSTCRAANVAYPKTEAELVSVVAAATQAGRKMRVTTRYSHSITKLVCTDGTEGLFISTKFLNHTVQADATAMTMTVESGMTLRQLIVEAAKVGLALPYAPYWWGLTVGGMMGTGAHGSSLWGKGSAVHDYVTEIRMVSPGSVNEGFAKIRILSETTTPNEFNAAKVSLGVLGVISQVTFELQPMFKRSLTYTMRNDSDFEDQAVTFGKKHEFADFIWLPSQGKVVYRRDDRVAVNTSGNGLFDFLPFRSQLSAAIAIIRTSEETQERFRDANGKCVGATIISSTLFAPSYGLTNNGIIFTGYPVVGSQNRMMSSGSCLDSLQDGLITACAWDSRIKGEFFHQTTLSVPLTQVKSFISDIKSLVKIEQKSLCGLELHYGILMRYVTSSPAYLGKETEALDFDITYYRAKDPLTPRLYEDFIEEIEQIALFKYNALPHWGKNRNLAFDGVIRKYNNAPAFLKVKDSYDPKGLFSSEWTDQILGIKGNASIVKDGCALEGLCICSKDAHCAPAKGYLCRPGKVYKEARVCTRVDGIISVI
Protein: Pescadillo homolog (Q9EQ61)
Organism: Mus musculus (Mouse)
Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli.
Interaction partners:
- Ribosome biogenesis protein WDR12
- GTP-binding protein 4
- Ribosome biogenesis protein NSA2 homolog
- Ribosome biogenesis protein BOP1
- Probable rRNA-processing protein EBP2
- Nucleolar complex protein 2 homolog
- mRNA turnover protein 4 homolog
- ATP-dependent RNA helicase DDX18
- WD repeat-containing protein 74
- Ribosomal L1 domain-containing protein 1
Sequence:
MGGLEKKKYERGSATNYITRNKARKKLQLSLPDFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIKFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNAVERLKDNKPCYKLDHIVKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFLHYVITARALRKVFLSIKGIYYQAEVLGQPIVWIAPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQSLNLHYPPKLEGQAQAETKISEDTYALDSESSMEKLAALSASLARVVVPAIEEAEADEFPTDGEVTAQEEDRKKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGDVSWDKSLCIGATYDVTDSCITHQIVDRPGQQTPIIGRYYVQPQWVFDCVNARLLLPVAEYFPGMQLPPHLSPFVSEKEGDYIPPEKLKLLALQRGEDPGHLEEEEEEDEDDDNEGDVAAENEEEDVEVESEEEEEEEVHLSALEQHRLEEKKPQVMAGTVKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDDAVRSEKKAKRTRPV
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Q389K5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein uL3m
- Rhodanese domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Mitochondrial RNA binding complex 1 subunit
- 50S ribosomal protein L17, putative
- 50S ribosomal protein L16, putative
- Ribosomal protein L22p/L17e
Sequence:
MFSHQLKRLLQKKSIHRYNWDPLPMYDPRKLVHASRHMDVETWREVPDPHWDERSYLVPDQMFYNIPVPPEYKDAYWWRELQARRVQCPVEWVSHRMYNKGDRQRYDFQDLAFRKKFEFSYEEVVKNAKDMRS
Protein: Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (OMPDCase) (OMPdecase) (Uridine 5'-monophosphate synthase) (UMP synthase) (P10652)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Orotate phosphoribosyltransferase
- Uridylate kinase
- Dihydroorotate dehydrogenase
- GTP cyclohydrolase II
- Ornithine carbamoyltransferase, mitochondrial
- Got1 family protein
- uridine/cytidine kinase
- uracil phosphoribosyltransferase
- uracil phosphoribosyltransferase
Sequence:
MSSKSHLPYAIRATNHPNPLTSKLFSIAEEKKTNVTVSADVTTSAELLDLADRLGPYIAVLKTHIDILTDLTPSTLSSLQSLATKHNFLIFEDRKFIDIGNTVQKQYHGGALRISEWAHIINCAILPGEGIVEALAQTTKSPDFKDANQRGLLILAEMTSKGSLATGEYTARSVEYARKYKGFVMGFVSTRALSEVLPEQKEESEDFVVFTTGVNLSDKGDKLGQQYQTPGSAVGRGADFIIAGRGIYKADDPVEAVQRYREEGWKAYEKRVGL
Protein: Heterogeneous nuclear ribonucleoprotein F (hnRNP F) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] (Q794E4)
Organism: Rattus norvegicus (Rat)
Function: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:10471789}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein K
- Heterogeneous nuclear ribonucleoprotein A1
- Heterogeneous nuclear ribonucleoprotein M
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Heterogeneous nuclear ribonucleoprotein C
- Heterogeneous nuclear ribonucleoprotein D0
- Heterogeneous nuclear ribonucleoprotein A3
- Polypyrimidine tract-binding protein 1
- Serine/arginine-rich splicing factor 1
- Heterogeneous nuclear ribonucleoprotein U
Sequence:
MMLGPEGGEGYVVKLRGLPWSCSIEDVQNFLSDCTIHDGVAGVHFIYTREGRQSGEAFVELESEDDVKLALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLDRMRSGAYSAGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD
Protein: Probable WRKY transcription factor 75 (WRKY DNA-binding protein 75) (Q9FYA2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein ZAT6
- Transcription factor MYB62
- Protein PHOSPHATE STARVATION RESPONSE 1
- Inorganic phosphate transporter 1-1
- Transcription factor AIG1
- Phosphate transporter PHO1
- Protein PHR1-LIKE 1
- Probable ubiquitin-conjugating enzyme E2 24
- F22C12.10
Sequence:
MEGYDNGSLYAPFLSLKSHSKPELHQGEEESSKVRSEGCSKSVESSKKKGKKQRYAFQTRSQVDILDDGYRWRKYGQKAVKNNKFPRSYYRCTYGGCNVKKQVQRLTVDQEVVVTTYEGVHSHPIEKSTENFEHILTQMQIYSSF
Protein: Growth hormone receptor (Q0R5T5)
Organism: Bos taurus (Bovine)
Interaction partners:
Sequence:
EGKLEEVNTILAIHDNYKHEFYNDDSWVEFIELDIDDPDEKTEGSDTDRLLSNDHEKSLNIFGAKDDDSGRTSCYEPDILEADFHVSDMCDGTSEVAQPQRLKGEADISCLDQKNQNNSPSNDAAPASQQPSVILVEENKPRPLLIGGTESTHQAVHTQLSNPSSLANIDFYAQVSDITPAGNVVLSPGQKNKTGNPQCDTHPEVVTPCQADFIVDNAYFCEVDAKKYIALAPHVEAESHVEPSFNQEDIYITTESLTTTAGRSGTAEHVPSSEIPVPDYTSIHIVQSPQGLVLNATALP
Protein: Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) (Q9NZJ0)
Organism: Homo sapiens (Human)
Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1.
Subcellular location: Nucleus {ECO:0000269|PubMed:26431207}. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.
Interaction partners:
- Cullin-4A
- Cullin-4B
- DNA damage-binding protein 1
- DNA replication factor Cdt1
- DDB1- and CUL4-associated factor 1
- Proliferating cell nuclear antigen
- E3 ubiquitin-protein ligase RBX1
- DNA damage-binding protein 2
- Cell division control protein 6 homolog
- DET1- and DDB1-associated protein 1
Sequence:
MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGWASQKKKESRPGLVTVTSSQSTPAKAPRAKCNPSNSSPSSAACAPSCAGDLPLPSNTPTFSIKTSPAKARSPINRRGSVSSVSPKPPSSFKMSIRNWVTRTPSSSPPITPPASETKIMSPRKALIPVSQKSSQAEACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSKDSLGPTKSSKIEGAGTSISEPPSPISPYASESCGTLPLPLRPCGEGSEMVGKENSSPENKNWLLAMAAKRKAENPSPRSPSSQTPNSRRQSGKKLPSPVTITPSSMRKICTYFHRKSQEDFCGPEHSTEL
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0B4KH16)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSDSDEDAREEVRQIKHGELRTAVISGDERTVRVLLAALGTERQIIVNMAPSGANTLLFLACQSGYESITQRLLDAGADGRSHAVTKYSPLYAAVHSGHLGIARLMLDHFPELIQQPTVERWLPLHAACINGHIKLLELLISYSYPDYLYQTYRDEEGQWEWRLPFDANAHDVTGQTSLYIASILGNKQLVGVLLKWQLHCRRTLGDSASSVSTPITPTRKRISFGIQAIMSKLHISGESEGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGGHLDVVQSLLQHGANPNIVAKPVEDHNDPKCCEEIYGLSNVPIAEACKQRSLAMLDLLLKHGARDDNGTAIGMAITCGDEAILSRLLARRVHPDSDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVPWMVSGVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLTSIPQELFHLVSLRYLNVAQNKITDLPAPIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNKLQQLPFDLWRAPKLRELNVAFNLLRDLPVPPMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFTSIPAALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTNNCLKEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKHKTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANISTVGVDIGTWICEKRKRAPGSHGPVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFIAIPDAEKIGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSKEPMLLQKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDATLRDYYFLDPQWLCDMLAHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNMLCCCLVGEAIWMGDVSGNLHAYSTSTYAHLFSYMLDPNIKSAVISLVYMEKIARVAVGTHNGRVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAACSVVVDGIYELWCGEIAGKINVFPLNENGVSGHQALCHSEEPNLIEDVKVARMCSNESHVFSCLYPGCMVYQWDVISKRIENKLDCSKLLPCSESLQSIAIDEHVNLIKCQISALAAHNSELYIGTTWGCLIVAELHTLRPISVFRPYENEIKSIITLSKDNVPLIATIGRRYRSLISRYVDSAESSTKSSAVSTPTHGAAKSVPPADVDNHIHCLLWRAKHWT
Protein: Ankyrin repeat-containing protein (Q86A02)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Uncharacterized protein
- 1-phosphatidylinositol 4-kinase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Phosphatidylinositol 4-kinase
- 1-phosphatidylinositol 4-kinase
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- SAC domain-containing protein
- Phosphatidylinositol-3-phosphatase SAC1
- phosphoinositide 5-phosphatase
- Phosphatidylinositol 3-kinase 1
Sequence:
MTICQPIPCGGSYFWNIVEPYKNDEYVFVMQSYNGPFRWKSEEYRIVLMCGPNSNGYIIATSTLFSEIFSNWEIITTIYKEKIEKTGLSHFSDTFLIQLYKKLAKKLSQVNSPIFTEEEQNIQPPPQPQLPPQQPPPPPQIQESQPIQEQIEQIILPTTLEFPKSRDNEEIKIIKKRKIVALFKTLYRVDAMTIIERDYSSSSQWIEWVDESTGMRPIHVAVERMNVQLVKYLIERKADVNIKDNQGWSPLHFSSFAGSLDICQILLDQGNAAVLTISKDGTLPLHYLIRHCYSINVPSSSSNSNNNKDNNNNNYKDNNKFNSNLSINYNNGGDCNNLTLKQKQESNNKLFSILSLLLSKGTPINAKTIRGETALHRACYYGSAQSVKFLHQNGADVNVQNSRGETPLYFAVVSRQREIVKLLIEYGSDVNIGGERSALKAADKTNQNEIYYFLAGFSDEKSVSDSKRDYYNNNDENDSNNNNNNYNDENDNIHRHNQNNQGNNQNHSMDCCSKIENGQECSCGDLSNTAHPFYPHVFVFIDFPAGTTHCSYCKYLLWGIRKQGFQCEVCSYIVHSRCKRQATLTNTCGIPDSKETISSSVVNDFLTKSRDQNINNNNEEEGVEVVEEDHHHNNINNNINNNNKRSPQRKQTIRQPLHKQNINRKRLESLYNHFITLDKEKKGSILKKDFEKCLGPIINSSESLSNALFLGFNPKKHDKMSYVEFLTGVSVLQNSTFDKQIQFSFKMLAGEKGYITVEEFLSILESIYSSLTNLTIVTCNPQAFLKRLFPEFSFSYQRKQKLLLQQQQQLQQQQQQQQQQQQQKSSWSSTSPSPSSTTNSLRNSLRLSRAIDNNNNHNNHNHNHNNSNINNEDDLNLDSDSDSDSFPTPSTSPLLFKIGIKNKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEQQQQQQQENQQIIKDENETVENQSQEIKQKEDENQKEVENQKQDLKNQKEEKEEEEEIKEQRKFETKNDNFVQVNTKKSVRGSIFFAPLDSHEKINNISSIGNHRSLIRNSSSSVLDNNSNNSNNNNNNKNNNESTATPNTTNSTTPITSATTSTSSSPSSSYKSQSLPDLPSHIPKTPTKSSIINNNNNTSKTITTKSSSSFENGLNNSGIDNNYISKKEKIENDKVFQLNGRIYFKEFKQALSDNLYFVKSLGLVNHYENPLIRETEGNDGLLVNHSSNWVTSQGKDVSIGHINWELIQYIMIGIRRSAGEAIVLTNRATLKPKDFEMVVEFKYDGWTFKDHYPLAFKKIRERLEIDPKMFMFSLGPERVFGNLLLGNLSVLSEMNSSGKSGSVFFRSTEGDYLIKTIPTHEESILKAVLPTYVQHLQKYPNSLLIKILGCYTLQIKGKAEMKFLVMNNLFFTPLPLSEKYDLKGSVINRKVDKNDLLLPDIALKDQEFHRILDIGPEFKAPLLEQIEHDTMFLESHNICDYSLLVGIHTIDENSPLALSDDDDPDLSNVGGVKRDTWKVLEEEFFKKTSGKISLFQKNFGGILSKNKKEVYFIAIIDTFTAWDWWKKSERALKFLGNDLDKISAVNPTDYRKRFQHYVSKIVQ
Protein: Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] (O70176)
Organism: Mus musculus (Mouse)
Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells.
Subcellular location: Secreted.
Interaction partners:
- Pituitary adenylate cyclase-activating polypeptide type I receptor
- Vasoactive intestinal polypeptide receptor 1
- Vasoactive intestinal polypeptide receptor 2
- Gastric inhibitory polypeptide receptor
- Glucagon-like peptide 1 receptor
- Follicle-stimulating hormone receptor
- Beta-1 adrenergic receptor
- D
- Thyrotropin receptor
- Adenosine receptor A2a
Sequence:
MTMCSGARLALLVYGIIMHSSVSCSPAAGLSFPGIRPEDEAYDQDGNPLQDFYDWDPPGVGSPASALRDAYALYYPADRRDVAHEILNEAYRKVLDQLSARKYLQSVVARGAGENLGGSAVDDPAPLTKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL
Protein: CLAVATA3/ESR (CLE)-related protein 2 [Cleaved into: CLE2p] (O49519)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signal peptide that regulates cell fate. May act with CLV1 as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions.
Subcellular location: [CLE2p]: Secreted, extracellular space {ECO:0000269|PubMed:19525968}.
Interaction partners:
- CLAVATA3/ESR
- CLAVATA3/ESR
- Receptor protein kinase CLAVATA1
- Protein CLAVATA 3
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
Sequence:
MAKLSFTFCFLLFLLLSSIAAGSRPLEGARVGVKVRGLSPSIEATSPTVEDDQAAGSHGKSPERLSPGGPDPQHH
Protein: Enolase-related protein 3 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) (P42222)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Pyruvate kinase 1
- Pyruvate kinase 2
- Phosphoglycerate mutase 2
- Phosphoglycerate mutase 1
- Glucose-6-phosphate isomerase
- Phosphoglycerate mutase 3
- Fructose-bisphosphate aldolase
- Transketolase 2
- Phosphoenolpyruvate carboxykinase
- Transketolase 1
Sequence:
MSITKVHARTVYDSRGNPTVEVEITTENGLFRAIVPSGASTGIHEAVELRDGNKSEWMGKGVTKAVSNVNSIIGPALIKSDLCVTNQKGIDELMISLDGTSNKSRLGANAILGVSLCVARAAAAQKGITLYKYIAELADARQDPFVIPVPFFNVLNGGAHAGGSLAMQEFKIAPVGAQSFAEAMRMGSEVYHHLKILAKEQYGPSAGNVGDEGGVAPDIDTAEDALDMIVKAINICGYEGRVKVGIDSAPSVFYKDGKYDLNFKEPNSDPSHWLSPAQLAEYYHSLLKKYPIISLEDPYAEDDWSSWSAFLKTVNVQIIADDLTCTNKTRIARAIEEKCANTLLLKLNQIGTLTESIEAANQAFDAGWGVMISHRSGETEDPFIADLVVGLRCGQIKSGALSRSERLAKYNELLRIEEELGDDCIYAGHRFHDGNKL