wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase 2A activator 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase PTPA-1) (PPIase PTPA-1) (Rotamase PTPA-1) (Phosphotyrosyl phosphatase activator 1) (O36016)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Uncharacterized protein C63.05
- Serine/threonine-protein phosphatase 2A activator 2
- Uncharacterized protein C216.01c
- Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit
- Protein phosphatase PP2A regulatory subunit A
- Leucine carboxyl methyltransferase 1
- Putative serine/threonine-protein phosphatase C26H8.05c
- Serine/threonine-protein phosphatase ppe1
- Type 2A phosphatase activator tip41
- Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit
Sequence:
MQVVDEKTILELENERFDESSQFKTPEKLIVEASDMTAFRQSKAYYRIFDFLQRLNIASVGVNDYHVEYSTRVEKLVRILCRVKEITKTVPPASGRHRFGNPAFRIWHEKLRDSASQIMDIIIPDSLSKAKVELLDYFLGSFGNSQRIDFGTGHELNFLGFIKGLDLLGLLDAADYKAIALYITHVYLEVCRELVQTYRLEPAGSHGVWGLDDHFFIPYIFGSAQLADKASSSIIKPDAILNKKIVDEKANSNLYFSAIKFINVMKKGPFYEHSPILYDITAVPIWSKVNQGLIKMYDVEVLSKYPVVQHFHFGNLFPFNPLVAK
Protein: Angiopoietin-like 2b (Angiopoietin-related protein 2b precursor) (B0UXH5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MYFTGVCVVMDVPSLVCLVLLLASGWFPETEGSPQEFDSSDEGPEVEFLSTTRTRRAPEPPPQDKCSYTFIVPQQKVTGAICVNSKEPEAVLENRVNKQELELLNSELHKQKRQIETLQQLVEVDGGIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLENKILNQTSEMLQLTNRYKDLEHKYQHLASLANNQSALIALLEAQCQRGPPVPRVPVQPQPQPQPQPQPHPQPRPSPPLNKPYQPPTFNRNNQITNEIQSDQNLKVPPAPPPTMPGGTHSPSTTNKPSGPWKDCLEALEDGHTNSGMHLVKPDNTNKLMQVWCDQRQDPGGWTVIQRRMDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWITNQGNYKLLVTLEDWSGRKTFAEYASFRLEPEADFYRLRVGRYHGNAGDSLTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWWYNACAHSNLNGVWYRGGHYRSRYQDGVYWAEFRGGAYSLKKVVMMIRPNPNTFH
Protein: Sterol uptake protein 1 (P53032)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor involved in the induction of hypoxic gene transcription when the cells are shifted from aerobiosis to anaerobiosis. Involved in sterol uptake.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MSTSITVRNRDRSLPPLLLPNVSLLEKDIRRKGTQNVGITDPELLSTTWTRKRAFPTDELLGGYKRLKPAAADSNECAIGIATVTPPPTLPVSAIVPPPQNYTPPLFEYHPHALASMVNEDANASCTQMSIISRSTSNSTTSSATSTSSISKRQRSGPSCDKCRLKKIKCNAKIEILLQDDTIMPMISNKLRYVLTPDDIRLYRGTLLRNIAIPDDVIEGTGSRKLIKHIDKLVLLTPCLPCIKKKHSSSSTNFPKNDKCTFSKGFTRADINISSKISLKFKDKTIYDITYDDYKSIDF
Protein: Netrin-3 (Netrin-2-like protein) (Q9R1A3)
Organism: Mus musculus (Mouse)
Function: Netrins control guidance of CNS commissural axons and peripheral motor axons.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11231084}.
Interaction partners:
- Neogenin
- Netrin receptor UNC5C
- Netrin receptor DCC
- Netrin receptor UNC5B
Sequence:
MPTWLWGLLLTAGTLSAALSPGLPASADPCYDEAREPRSCIPGLVNAALGREVLASSTCGRSANRVCDSSDPQRAHSADLLTSAPGTASPLCWRSDLLQQAPFNVTLTVPLGKAFELVFVSLRFCSAPPTSVALLKSQDHGRSWVPLGFFSSSCTLDYGRLPAPADGPSGPGPEALCFPAPQAQPDGGGLLAFSVQDGSPQGLDLDNSPVLQDWVTATDIRIVLTRPAIQGDTRDGGVTVPYSYSATELQVGGRCKCNGHASRCLLDTHGHLVCDCQHGTEGPDCSRCKPFYCDRPWQRATGQEAHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRVLSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPVPGPTEESSPVEPQDCESHCRPARGSYRISLKKFCRKDYAVQVAVGARGEARGSWTRFPVAVLAVFRSGEERARRGSSALWVPTLDAACGCPRLLPGRRYLLLGGGPGAAAGSTAGRGQGLSAARGSLVLPWRDAWTRRLRRLQRRERRGRCGTA
Protein: Spectrin beta chain (Q91ZE6)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAQVPGEVDNMEGPAVSNNNNPSARWESPDRGWDREPPAAANAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYADLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDLSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVDKIIERYEELAAELLAWIHRTVDLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDARRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQTQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQPCDPQVICNRVNHVHGCLSELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEATSGSGGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRRGEELAAAGGSVGPGAEPLHLAGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVGGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLAMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNQTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQATRLHQGAEELGAEWGALAGAAQACGEAVAAAGRLQRFLRDLDTFLDWLVRAQEAAGAVEGPLPRSLEEADGLLARHAALKEEVDQREEDYARIVAASEALLASEGAELGPGLALDEWLPHLEVGWHKLLGLWEERREALVQAHVYQLFLRDLCQALAVLRNQEVALSGAELPCTVESVEEAMKRHRDFLTTMELNQQKMQVAVQAAESLLRQGNAYGEQAQEAVARLLEKSQENQLRAQQWMQKLLDQLVLQHFLRDCHELDGWIHEKMLMARDGTREDSHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKRLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWCREVGELQAQTAALPLEQASKELVGERQSAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGTGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGVLASLRSPEAEAVRRGQEQLQSAWTGLREAAERRQQTLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVSLEQQYWLYQLSRQVDELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGTAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTADALRFHSQARDLLSWMDGIAGQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELATCQELGRSLLLNKSAMADEIQAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYDRGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPETSGKVEPAAPTAAALDTTDTPGTPAATELVRPRSERQELADRAEELPRRRRSERQESVDQPEETARRRRPERQESADHEGPHSLTLGRYEQMERRRERRERRIERQESSEQETPTRGELVKGKATLADIVEQLQEKEAGPGIPAGPSLPQPRELPPGRLPNGLEPPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVSLYCVLSKGELGFYKDSKGPASGGTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVANSVAEHAEIARWGQTLPTTSSTDEGNPKREGGERRASGRRK
Protein: Uncharacterized protein (Q585R2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFASQSISLYKECCQFYNVKPNTEILQQVDTPQLMLEEIDASRTLLGELGVKALLDCISCHVGIRRVVLKKNGLSTTCVEHLCRFLRGSRYVCHVDVSENPMNVAAARVLWETARIVPTLTEINVEKCELEDEWPRRLERCCKSNEETQAAVIAPCAEDLNPMQWDVVFVAVAGPASYVEKYSTEILPPVSSLLAQYRLRVCLLAIDENDTPDVAVAKIERCAERYNHGLSWCVALVDDAVPWNEAALKAVMATVQQTRPITKPLKDKFGAICSPAIKCVTNFFVYDVTLLSESDEKGEEKPDTAGVVEVPPEKWFPAVNWDEVGDCDVPSAVRLRTKNCWKVRCQSDLYCALTDVFSRKFTMEEGSQNEEKEVDEEKAYILTSEKESLFSSYPMCKEIVLHVEKRLWSTCVPIVLIGTDVKAHNNVLSWLANKYAESGPMKVVFYPYKRDNRSMVVFLSYLLGVLSKSPMELYLSLDTLCNEVHDAISHYEDEPLLMIIPSMDTLDSCGNDYCCSLDWLPSTLPPKITLVVSIKTESPILVAFRKRLPQPFEVLNAPLPDEVRSWLFTEELVRRGILGGTAGGHQEDGGDTSNCEAWKRVVGNAFLNKDGSKFTSFDTYAASLLFRFSLTTDSEDVTFFLPSEVPNTMRELLVKLLKVHEDQGDPLTVRYVLTCLAAASLPVTEVVCVCEDLGPCPRNKTIPVLLMLIDDGIVEIHGGSVAHLAGPEVHEVVNSLYSDLLDNVNALVENHLYRLVKTRSPDLSLCFRQIGPLIFVNGSFENAYSLILDASIMDAAFSREKSNTQYAIDIIFRLLNSYRLLSQLHDGEYFVFDKQDQSQRRSALLNAAKDIQSFDCFFFQSALQLSEVSPYYRDASTSEEVPYSVLAPLNTAGEEGSSISIPVNETPIYVHLREKYLVISTKTTVFVYSTGNFDKVVATFDTTCNKDAVFQGALSACGTRIVLIWDRHLATFDFLTGGHSNVDDVTATLSDRALDVLGTNIAVQHNLSKSLSIMDLTKKNKVIILPTLEAEAREAYFFGSSVLATSLYDLFIIRGCRVQKLSHTGVIRCVAFPASDRLIASSVDEDIWIWSGAGELLHIANAGRTPIEELYLNSNGGQLLSRQQEGLKLWETSSGRFKKLDQLFDEIPTQLLITGSDSFIIALCGYYLYVWDASTRRPVGVLTCAIGAITFVQERNQLVMALTSRNEVKVWRLGDNPFLSTKVLQKKSLSSNWRLSGKLSAVSIERITANSKGTLFAALDSDGALLLQPTKGGPPTVCAVKEVEGMVFLCNYLVFSFKEKAGCFCYIDLDEEEFKVSEMLLPTDAREKASLDFVADPDDRYLAVVSNFDKGSTLYVYEVSTWSLLNQFIGHSGHVFYGFFVEDVLISVCKDLTVRCWSLQNHAERTSYKHPFQIAAAARDTESPVVSLFFFDVYFHLFHLHVDGVDSSARFEVQKVSTLPPPATLKPVQCVYVSGLVVVVAGCGSVFLVNVRRGGAATKLSNYKCLCVATYKNGPESFVLTGHTTGEVLLNGVRHGP
Protein: Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97) (Q9Y5N1)
Organism: Homo sapiens (Human)
Function: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Histidine decarboxylase
- D
- Chloride intracellular channel protein 4
- Histamine N-methyltransferase
- D
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
Protein: Transient receptor potential cation channel subfamily V member 1 (Transient receptor potential cation channel, subfamily V, member 1) (B0S711)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Transient receptor potential cation channel, subfamily A, member 1a.
- Transient receptor potential cation channel, subfamily C, member 1
- Transient receptor potential cation channel, subfamily M, member 3.
- Short transient receptor potential channel 4b isoform X1
- Transient receptor potential cation channel, subfamily C, member 3
- Transient receptor potential cation channel, subfamily M, member 7.
- Transient receptor potential cation channel, subfamily M, member 6.
- Transient receptor potential cation channel, subfamily C, member 5a
- Transient receptor potential cation channel, subfamily M, member 4a.
- Short transient receptor potential channel 6a isoform X1
Sequence:
MDSSVSSFSLETDDQTEEERTKAKQMKKVSKDKRPMDSNYVDDVVEPSSTIKFNLHFDRGIRNLKEEPAQQDNDRFTIKRLFEAVSSGDVSKMQGLHEYLHKNMKRLTDSQYKSNGKTALLKALLNLRQGENDTIEQLLDIAEKMGDLKNFINAAYTDSYYKGQTALHVAIERRSMKFVQMLVKKGADVHAKACGKFFQPNQKMCFYFGELPLSLAACTNQQDIVDFLMENPHQAVDVRERDCHGNTVLHALVSVADNSPENTEFVIAMYDHILIKADQLHPKTKLEEIENNEGLTPITLAAKKGKLGLFKHIVQRELMGCRHLSRKITEWAYGPVCSSLYDLSSLDTYEKNSALEIVVYGSEIPNRLEMLQIEPLNRLIEEKWDQFAHRMFLFNFIVYVIYLFIFTASAFYHEEGKDYANQPPYLYAKSREGYLLLTGHIISITGAFYFFIRGLIDMVRKRPRFQSLIIDGYTDQLFFVQGLLFLASVVLYCYGQYEYLAFLVLCLALSWINLLYFSRGSKNLGIYNVMIQKMVLGEIRRFLVVYMVFLIGFSAALVTLLDQESIDSGSTRDFRLSEDIPSLNPTPDSSNPQSRMTHHQPTTARDGRGRFGLTTDNQYEVCKKPSYKNIYFTTLELFKFTIGMGDLEFTDHYKYKEVFYVLLIVYIVMTYILMLNMLIALMNQSVEMMSVESTSIWKLQRAITTLDMEWILPKCLQGKLRSGEEKDLGGGQEPDRRWCFSVEEVNWTQWNRNMGIIINEDPGKCTQDPSPANVQREPSRGVLQTFSRRRRTQRAQTREGHELSPLAEASSSV
Protein: Melatonin receptor type 1a (I2E112)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
GNIFVVSLAIADLVVAIYPYPLVLTSVFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVGLIWVLTVVAIVPNLFVGSLQYDPRIYSCTFAQSVSSAYTIAVVFFHFILPIAIVTYCYLRIWILVIQVRRRVKPDNNPRLKPHDFRNFVTMFVVFVLFAVCWAPLNFIGLAVAVDPETIIPRIPEWLFVSSYYMAYFNSCLNAIIYGLLNQNFRREYKKIVVSFCTAKAFFQDSSNDAADRI
Protein: Gibberellin 2-oxidase (Q68Y45)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MVVLAKPAALEQISLVRSPSVEDNFGAGLPVVDLAADGAAGEVVRACERFGFFKVVSHGVGEGVVGRLEAEAVRFFASPQAAKDAHGPASPFGYGSKRIGRNGDMGWLEYLLLVALHHDADAGDHQWVTVPPDPASFLVIVGDSLQVMTNGRMRSVRHRVVANKLKSRVSMIYFGGPPLEQRIAPLRQLLVAGVGNGEEEEQSRYEEFTWGEYKKAAYLSRLSDNRLAPFHRQPPPVANPLA
Protein: Photosystem II reaction center protein L (PSII-L) (P60137)
Organism: Oryza sativa subsp. japonica (Rice)
Function: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01317}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01317}.
Interaction partners:
- Cytochrome b559 subunit beta
- Photosystem II reaction center protein J
- Photosystem II reaction center protein T
- Photosystem II CP47 reaction center protein
- 33 kDa subunit of oxygen evolving system of photosystem II
- Cytochrome b559 subunit alpha
- Photosystem II reaction center protein H
- Photosystem II reaction center protein K
- Photosystem II reaction center protein I
- Photosystem II D2 protein
Sequence:
MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
Protein: Histidine-containing phosphotransfer protein 5 (Q8L9T7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:18642946}. Nucleus {ECO:0000269|PubMed:18642946}.
Interaction partners:
- Histidine kinase 2
- Histidine kinase 3
- Histidine kinase 4
- Two-component response regulator ARR1
- Two-component response regulator ARR2
- Two-component response regulator ARR10
- Two-component response regulator ARR12
- Two-component response regulator ARR14
- Two-component response regulator ARR18
- Two-component response regulator ARR22
Sequence:
MNTIVVAQLQRQFQDYIVSLYQQGFLDNQFSELRKLQDEGTPDFVAEVVSLFFDDCSKLINTMSISLERPDNVDFKQVDSGVHQLKGSSSSVGARRVKNVCISFKECCDVQNREGCLRCLQQVDYEYKMLKTKLQDLFNLEKQILQAGGTIPQVDIN
Protein: Sphingosine kinase 2 (M0R0E9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAPPPPPLAASTPLLHGEFGSYPARGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTYPRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGG
Protein: Interferon gamma (IFN-gamma) (Q9YGB9)
Organism: Anas platyrhynchos (Mallard) (Anas boschas)
Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MTCQTYCLFVLSVIMIYFGCSGSALFLGQLQNDIDKLKADFNASNSDVADGNPVFIEKVKNWTERNEKRIILSQIVTLYLEMLKKTDMSKPHIKNLSEQLNTLRNTLSNDYKKFRDLVELSNLQLTGLKIQRKAVSELFSVLQKLVETSTSKRKRSQSPKRCRC
Protein: AT4g23680/F9D16_150 (Polyketide cyclase/dehydrase and lipid transport superfamily protein) (Putative major latex protein) (Q9SUQ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein P2x
- FCS-Like Zinc finger 5
- AT3g20100/MAL21_14
- B3 domain-containing protein REM20
- TSK-associating protein 1
- Myrosinase-binding protein 1
- MLP-like protein 423
- Cellulose synthase-like protein E1
Sequence:
MATSGTYVTEVPLKGSAEKYYKRWKNENHVFPDAIGHHIQNVTVHEGEHDSHGSIRSWNYTWDGKEEVFKERREIDDETKTLTLRGLEGHVMEQLKVYDVVYQFIPKSEDTCIGKITLIWEKRNDDSPEPSGYMKFVKSLVADMGNHVSKT
Protein: histidine kinase (EC 2.7.13.3) (Q9I2U4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Two-component response regulator, ParR
- Response regulator protein PmrA
- Two-component response regulator PhoP
- Chromosome partitioning protein Soj
- Two-component response regulator, CopR
- Probable two-component response regulator
- Two-component response regulator
- Transcriptional activator protein PfeR
- Probable two-component response regulator
- Two-component response regulator CreB
Sequence:
MLRLFLRLYLLLALGFAAAIFVVDHVIDAFYDSIVENYHRDAVRGQAYSLVEKLAPLDQAGRQRQLEDWRPHYGLELSLTDARQAKLTQEEQALLDKNLLVVREDFTEFISRIDAGPQLLDIKLPPEPSLTPLFTVLAYILLGVLVGIALLVWVRPHWRDLETLRLAAQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRIESLISNQRELTNAVSHELRTPISRLSFELEQLNKQVDAEVRHDLIEDMRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEISACQVEQIRIEPRFMARAVINLLRNAIRHAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVHRVAQWHGGYAEALETPQGGASFRLTWERPR
Protein: PIP1 protein (Probable aquaporin PIP-type 7a) (A0T2N6)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEGKEEDVRLGANKFTERQPIGTAAQSQDDGKDYTEPPPAPFFEPGELTSWSFYRAGIAEFVATFLFLYITILTVMGVVKEKTKCPTVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAIFYMVMQCLGAICGAGVVKGFMGKTQYGMLGGGANSVAHGYTKGDGLGAEIVGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKDKGWDDHWIFWVGPFIGAALAALYHVVVIRAIPFKSK
Protein: Uncharacterized protein C12B10.02c (Q10436)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MSNVQRKRIDIRRPTLAELSSIRSIAMNALNGQSRNLSQKIFWHPLYLAVFGLVFMGIYRLTNMVEGNTKLRTFVLLILVSAVFLTLIEFPCRNVYAKISTEDNQPDGCLAEENLKHFYMARIDKERVIGIIGILPANAPGAYQNTPTIVHWTVIPKFYQYAFDLLDSALREAKEMGADVVSARVYSTDPMLKAFERKDFTPVVDEAFDYLSFFGLRRLVLQKNLSEQPGFENRR
Protein: Recoverin (Recoverin-2a) (Q6PC38)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- G protein-coupled receptor kinase
- Rhodopsin kinase grk7a
- G protein-coupled receptor kinase
- Rhodopsin kinase grk7-b
- Green-sensitive opsin-2
- Green-sensitive opsin-4
- Rhodopsin
- Rhodopsin
- Green-sensitive opsin-3
- Rhodopsin.
Sequence:
MGNAKSSAMSKEILEDLKLNTKFSENELSQWYENFQKQCPSGRITPEEFKKIYERFFPECDTTSYAQHVFRSFDTNDDGTLDFKEYIIALHMTSTGKTERKLEWAFSLFDVDKNGYITKSEVAEICQAIFKLIPKEDQESLPADENTPEKRADKLWSYFNKKDNERLAEGEFIQGILENEDAIHLIQFEHQKK
Protein: Thimet oligopeptidase (EC 3.4.24.15) (Q8C1A5)
Organism: Mus musculus (Mouse)
Function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P47788}.
Interaction partners:
- Kininogen-1
- HMW kininogen-II
- Calmodulin-1
- Prolyl endopeptidase
- Neurotensin/neuromedin N
- Nardilysin
Sequence:
MKPPAACAGDVVDAASPASTVNHLRWDLSAQQIRALTTQLIEQTKCVYDRVGAQNFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPCKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQEKTPKNSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLSSLEKAEDGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSSLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQLAVAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGSEAPQDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASAMLKQFLGRDPKQDAFLLSKGLQVEGSEAPAC
Protein: Increased minichromosome loss 1, isoform E (M9PDV3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKLYKLNTHTRGCNKSYDADLVMNLKDHPNANVGDVVEIYAPDEENGTHLLLQITEFNGSCGRDVISIESGIANAFKMRPYSNVVMRIVKPADVALDSIEITFKDQYMGRSEMWRLKTYLTDTCVYVNKKIDYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWDFDIHGDLYFEKAVNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRDCLQQDYKGRFYEDFYRVAIQNERCDDWCTVLGQLRKLFTSYQATVLRYHERENMKIPPATNSSATQGNFLEVLNISLNTFEKHYLDRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAVPLLKFHNKDTTLTSADDYSLPHWINLSFYSTNKKIVYSSFIPRIKLPLFGSQLTLHDGVGDGEGEENERHFLSCNQSEYKHNSLFDYDAYDEQIFQPLPAQSTCSLQRVVRAKKTSVPSLETYAYRNNDWENLTPTQIPAMRRKMSDPDIHHGTSAMLAALQPDTTNLSESLASEKNSRRTIVSIAPIVRPGRALINPFDPSQVTIKLTSNRRRWTHIFPKGPTGVLIQQHHYQAVPAKPTQAGQQRPLQQTQSNNNNDQEDYGCENGEQYDRVSSHSLLNKSDSSQSFVMGDEPIDFFKRRQNSPMNPQPANVPNLTATQAKSYLWGATGEQEWTPAITTGVDWKSLTIPACLPITTDYFPDKRSLNNDYVISDYTLLPDDVNHDYAQSRAVYRKPLSTEEVCKEIVSQRLAQGFQLIVVDEKPPTASGCSSGSAVQPVKLSRETNKEYLLSIGRIFHKISLSGSVITVTGYRPRHPYPPINVDYRYRFHAPQHETYEISGVNFTTEKLENFNWNHMDLYICTRGDVDYPLMESLKYWRYRMYLLPRENIVSKIASCQRCDIFPDVTADNTREQVEDFVRLIEAVSKLKRQYARKARYLASLLQDSPIAHITKRRHSTSIISRPQPNQGLTNSPFRERVGSNRLPEKRPSINVRPKLENGRIPRIFPATDAAAAAGVAARDDQDDGFPVDIKFSPNATLPEIFEAMKHPVNGVGFFSQTQSLPSCTFVSYDALMWLKTRLNNGRHPLDLLEAMRKERMICHASGDWKKPVVPGFVFYYVVQQDKNAKDYAPPLDDYSAFVNEWLEIEFQGCSFLWHDEPVTTPVPNFLRDSPAPQSWTETSSNKRVYRQSHLEIDVNQKSDRMEWGHVKHHTVLQPRFAFEIVVEWVTSSGPIVADLIGGWMRKANQFNFLVSVPADPMAEPFTKKSDPLRGPIFIPLCTTFLPNGAALFDEFPEESRSDRMLFFQEAILGKFGFLPCVLEKKYSVGKDLPKEYQYVHCTGNMFALIRCATNNYQVESPILKEANVTRCVYGHTNNTNVPKKVGFLWAWNHMIPNKKWKAQTINNSADGELFQLKMLKDFREFCSNSDQRLSTFWTQSQELKRRAQKFEFNNNNTEENKMK
Protein: Protein tyrosine phosphatase non-receptor type 2 (K7EIY0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKSFPHFKKKSKQRNKSFS
Protein: Mediator of RNA polymerase II transcription subunit 29 (Intersex-like protein) (Mediator complex subunit 29) (Q8JHI6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 11
Sequence:
MASQQMSTNNAQMSAQQAAVLQQTQAQQLSQQQDFDPVHRFKMLIPPLKDSLQNVMTIASLNFAHNTAIDNGLKTTEKGNDAAVQRFDKSLEEFYALCDQLELCLRLAHECLSQSIDSTKHSPNLVPTATKPDTVQTESLSYSQYLSMIKSQISCAKDIHNALLECSKKIAGKGQGACN