wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome P450 2F2 (EC 1.14.14.-) (CYPIIF2) (Cytochrome P450-NAH-2) (Naphthalene dehydrogenase) (Naphthalene hydroxylase) (O35293)
Organism: Rattus norvegicus (Rat)
Function: Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or club cells in lung.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Interaction partners:
- Epoxide hydrolase 1
- Cytochrome P450 2E1
- Cytochrome P450
- Glutathione S-transferase alpha-3
- Glutathione S-transferase Mu 1
- Glutathione S-transferase P
- Glutathione S-transferase kappa 1
- Glutathione S-transferase
- Glutathione S-transferase theta-1
- Hematopoietic prostaglandin D synthase
Sequence:
MDGVSTAILLLLLAVISLSLTFTSWGKGQLPPGPKPLPILGNLLQLRSQDLLTSLTKLSKDYGSVFTVYLGPRRVIVLSGYQTVKEALVDKGEEFSGRGSYPIFFNFTKGNGIAFSDGERWKILRRFSVQILRNFGMGKRSIEERILEEGSFLLDVLRKTEGKPFDPVFILSRSVSNIICSVIFGSRFDYDDERLLTIIHFINDNFQIMSSPWGEMYNIFPSLLDWVPGPHRRVFRNFGGMKDLIARSVREHQDSLDPNSPRDFIDCFLTKMVQEKQDPLSHFNMDTLLMTTHNLLFGGTETVGTTLRHAFLILMKYPKVQARVQEEIDCVVGRSRMPTLEDRASMPYTDAVIHEVQRFADVIPMNLPHRVIRDTPFRGFLIPKGTDVITLLNTVHYDSDQFKTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGEPLARMELFIYLTSILQNFTLHPLVEPEDIDLTPLSSGLGNLPRPFQLCMRIR
Protein: RAB33B, member RAS oncogene family a (Zgc:114080) (Q498P3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037868}; Lipid-anchor {ECO:0000256|ARBA:ARBA00037868}.
Interaction partners:
- ATG16 autophagy-related 16-like 1
- ATG16 autophagy-related 16-like 2
- Zgc:101559.
- TBC1 domain family member 25
- RAB33A, member RAS oncogene family
- Guanine nucleotide exchange factor subunit RIC1
- A kinase
- ATG16 autophagy-related 16-like 2
- Autophagy protein 5
Sequence:
MADIESSFEFSSSLTSSSLPPPRTRIFKIIVIGDSGVGKTCLTYRFCAGKFPDKTEATIGVDFREKVIEIDGEKIKVQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDVTNAASFRSLPAWIEECRQHALGQEVPRILVGNKCDLRHAAQVSTDVAQQFADTHSMPLFETSAKNPYGNEDGTQNNSDHVEAIFMTVAHKLKSQKPLVLSQPPCGYGDTVTLRRQDQEDGGNWGCGCWRS
Protein: Protopine 6-monooxygenase (EC 1.14.14.98) (Protopine 6-hydroxylase) (P6H) (F2Z9C1)
Organism: Eschscholzia californica (California poppy)
Function: Catalyzes the conversion of protopine and allocryptopine to dihydrosanguinarine and dihydrochelerythrine, respectively, in the biosynthesis of isoquinoline alkaloid sanguinarine.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDSLMLAYLFPISVASIIAFVFLYNLFSSRTLKNKKIRTAPMATGAWPVLGHLHLFGSGELPHKMLAAMADKYGSAFRMKFGKHTTLVVSDTRIVKECFTTNDTLFSNRPSTKAFQLMTYDNESVAFTPYGSYWREIRKISTLKLLSNHRLQAIKDVRASEVNVCFKTLYDQCKNPSGSAPILIDMKKWFEEVSNNVVMRVIVGRQNFGSKIVQGEEEAIHYKKVMDELLRLASLSMFSDFAPLLGFVDIFQGNLSAMKRNAKKVDAILENWLEEHRKKKNSVAESQQDFMDVMLSIVEESKLSGHDADAVIKATCLAMIMGGTDTTAVSLTWIISLLMNNRHALKKAREELDALVGKDRQVEDSDLKNLVYMNAIVKETMRMYPLGTLLERETKEDCEIDGFHVKGGTRLLVNVWKLQRDPNVWVDPTEFRPERFLTENADIDVGGQHFELLPFGAGRRVCPGVXFALQFMHLVLARLIHGYDLNTLNEENVDLTESPEGHVNHKASPLDLILTPRLHYKLYE
Protein: Metal transporter (F1Q7I7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU369091}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Phospholipid-transporting ATPase
- Solute carrier family 41 member 1
Sequence:
MATEWSGKGCTLTLILFLWSRVCGSKAESLGSDSRILGMRLERSDKPAMTTEDGIIQVTEESDIQLRFYGLQISNDTWAQIKFMEQGEDSSSDSNRTCADFTKDISVRTSMSVNSLGTSGVLGVKIKPLRKSESQRDYGLCIRQNGRWFSLGEHDGRLRVVEEKKSMLPIWFQVILICCLLVLSGMFSGLNLGLMALDPMELRIVQSCGTDKEKKYARKIEPIRRKGNYLLCSLLLGNVLVNTTLTILLDDLIGSGLGAVVASTIGIVIFGEIVPQALCSRHGLAVGANTIHVTKFFMFLTFPLSYPISKLLDCVLGQEIGTVYNREKLVGMLKVTEPYNDLVKEEMNMIQGALELRTKTVEDVMTPLNNCFMINSDAVLDFNTMSEIMESGYTRIPVYEDERTNIVDILFVKDLAFVDPDDCTTLKTITKFYNHPVHFVFHDTKLDSMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKCEILDESDLYTDNRNRKKVAHNKNKRDFSAFKHESESKVKISPQLLLAAHRFLATEVSLFSPSQISEKILLRILKHPDVIQEIKFNENDKKSSHHYLYLRGKPVDYFILILQGRVEVEAGNENMKFETGPFSFYGVMALSAPTLEFRSPSHISGLNRSASLSYTDRPESQSVSGSNTQLSSSALPQYTPDFNVRALADLQFVKITRSQYQNGLMASRLDSSPQSPDSGHGRQVDMDNSTSSAPHRTSENMLTLADASDETTSLLNEQNSQPARQANHNTHNESAI
Protein: Heptahelical transmembrane protein 3 (PAQR family protein HHP3) (Q9ZUH8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in abiotic stress response.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MKRRRSAKKSPAMVTVTDWKGLDCGEETRIVRRLMKFEDLPEYLKDNEFIHNHYRCQWSLKDTFLSAFSWHNETLNIWTHLIGFGIFLWMTVVSCLETTEISLAGVFNGMAGVRICLSSNQTLLHDSNVTHHISCLTSQGEAIPKWPWLVYLVGAMGCLICSSVSHLLACHSKRFNVFFWRLDYAGISLMIVASFFAPIYYAFSCHPNFRLLYLSSISILGLLAIITLLSPALSTPRFRPFRANLFLAMGSSAVIPATHVLCLYWDHPNVFIALGYEIATALSYFVGATFYVSRVPERWKPGAFDMAGHSHQIFHVFVVMGALAHCVTTLLIIDFSRASPSCGF
Protein: Transcriptional activator HAP3 (UAS2 regulatory protein A) (P13434)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'.
Subcellular location: Nucleus.
Interaction partners:
- Transcriptional activator HAP5
- Transcriptional activator HAP2
- Transcriptional activator HAP4
- AP-1-like transcription factor YAP5
- Protein MTH1
Sequence:
MNTNESEHVSTSPEDTQENGGNASSSGSLQQISTLREQDRWLPINNVARLMKNTLPPSAKVSKDAKECMQECVSELISFVTSEASDRCAADKRKTINGEDILISLHALGFENYAEVLKIYLAKYRQQQALKNQLMYEQDDEEVP
Protein: RNA polymerase II degradation factor 1 (RRM3-interacting protein 1) (P35732)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II. Also involved in telomere length regulation. Binds DNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23993092}. Nucleus {ECO:0000269|PubMed:15863512, ECO:0000269|PubMed:23993092}. Chromosome, telomere {ECO:0000269|PubMed:15863512}. Note=During transcription stress, localizes to the nucleus following proteolytic cleavage by the proteasome. {ECO:0000269|PubMed:23993092}.
Interaction partners:
- DNA repair and recombination protein RAD26
- PH domain-containing protein YHR131C
- Uncharacterized protein YNL144C
- DNA-directed RNA polymerase II subunit RPB1
- DNA repair protein RAD7
- m7GpppN-mRNA hydrolase
- Protein SLF1
- Elongin-C
- Tubulin beta chain
- Suppressor protein MPT5
Sequence:
MSTQFRKSNHNSHSSKKLNPALKSKIDTLTELFPDWTSDDLIDIVQEYDDLETIIDKITSGAVTRWDEVKKPAKKEKYEKKEQQHSYVPQQHLPNPEDDITYKSSNNSNSFTSTKHNSSNNYTQARNKKKVQTPRAHTTGKHVNLDKGKHVPSKPVSNTTSWAAAVSVDTKHDVPQDSNDNNNEELEAQGQQAQEKNQEKEQEEQQQQEGHNNKEEHKQIEQPSLSSKKTTSRTSASQPKKMSWAAIATPKPKAVKKTESPLENVAELKKEISDIKKDDQKSEASEEKVNEQETSAQEQEEETAEPSEENEDRVPEVDGEEVQEEAEKKEQVKEEEQTAEELEQEQDNVAAPEEEVTVVEEKVEISAVISEPPEDQANTVPQPQQQSQQPQQPQQPQQPQQPQQPQQQQQPQQPQQPQQQLQQQQQQQQQPVQAQAQAQEEQLSQNYYTQQQQQQYAQQQHQLQQQYLSQQQQYAQQQQQHPQPQSQQPQSQQSPQSQKQGNNVAAQQYYMYQNQFPGYSYPGMFDSQGYAYGQQYQQLAQNNAQTSGNANQYNFQQGYGQAGANTAAANLTSAAAAAAASPATAHAQPQQQQPYGGSFMPYYAHFYQQSFPYGQPQYGVAGQYPYQLPKNNYNYYQTQNGQEQQSPNQGVAQHSEDSQQKQSQQQQQQQPQGQPQPEVQMQNGQPVNPQQQMQFQQYYQFQQQQQQAAAAAAAAAQQGVPYGYNGYDYNSKNSRGFY
Protein: Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1) (O88485)
Organism: Mus musculus (Mouse)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Subcellular location: Cytoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}.
Interaction partners:
- Cytoplasmic dynein 1 heavy chain 1
- Cytoplasmic dynein 1 light intermediate chain 1
- Dynactin subunit 1
- Cytoplasmic dynein 1 light intermediate chain 2
- Dynein light chain 1, cytoplasmic
- Dynein light chain 2, cytoplasmic
- Dynactin subunit 2
- Dynein light chain roadblock-type 1
- Protein bicaudal D homolog 2
- Dynein light chain
Sequence:
MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVPTPMSPSSKSVSTPSDAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVEPKIGHDSELENQEKKQETKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYSNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNSDTEVPTASVAIEGASALNRVRWAQGGKEVAVGDSEGRIWIYDVGELAVPHNDEWTRFARTLVEIRANRADSEEEGAVELAA
Protein: LRR receptor kinase SERK2 (EC 2.7.11.1) (BRI1-associated receptor kinase 1 homolog 2) (OsBAK1-2) (Somatic embryogenesis receptor kinase 2) (OsSERK2) (Q7XV05)
Organism: Oryza sativa subsp. japonica (Rice)
Function: LRR receptor kinase involved in positive regulation of somatic embryogenesis and defense response against the rice blast fungus pathogen Magnaporthe oryzae. Involved in the positive regulation of receptor kinase-mediated immunity. Required for immunity mediated by the LRR receptor kinases XA21 and XA26/XA3 which recognize effectors from the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo). Required for the immune response mediated by the LRR receptor kinase FLS2 which recognizes specifically the bacterial flagellin (flg22) effector. Kinase activity and direct interaction with the immune receptors is critical for their function. Involved in the regulation of plant growth through the brassinosteroid (BR) signaling pathway.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Brassinosteroid LRR receptor kinase BRI1
- non-specific serine/threonine protein kinase
Sequence:
MAEARLLRRRRLCLAVPFVWVVAVAVSRVGANTEGDALYSLRQSLKDANNVLQSWDPTLVNPCTWFHVTCNPDNSVIRVDLGNAQLSGALVPQLGQLKNLQYLELYSNNISGTIPNELGNLTNLVSLDLYLNNFTGFIPETLGQLYKLRFLRLNNNSLSGSIPKSLTNITTLQVLDLSNNNLSGEVPSTGSFSLFTPISFANNKDLCGPGTTKPCPGAPPFSPPPPFNPPTPTVSQGDSKTGAIAGGVAAAAALLFAVPAIGFAWWRRRKPEEHFFDVPAEEDPEVHLGQLKRFSLRELQVATDNFSNKNILGRGGFGKVYKGRLADGSLVAVKRLKEERTPGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASRLRERQPNDPPLEWQTRTRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKVEMLVDPDLQSGFVEHEVESLIQVALLCTQGSPMDRPKMSEVVRMLEGDGLAERWEEWQKVEVVRQEAELAPRHNDWIVDSTYNLRAMELSGPR
Protein: Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] (P07339)
Organism: Homo sapiens (Human)
Function: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Subcellular location: Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). {ECO:0000269|PubMed:20551380}.
Interaction partners:
- Lysosome-associated membrane glycoprotein 1
- Cathepsin B
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- BH3-interacting domain death agonist
- Angiotensinogen
- Cathepsin D
- Cathepsin S
- Procathepsin L
- Progranulin
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
Protein: Cytosolic sulfotransferase 2 (EC 2.8.2.-) (SULT1 ST2) (Q7ZUS4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including 2-naphthol, hydroxychlorobiphenyls, T3 (triiodo-L-thyronine), T4 (thyroxine), estrone and DOPA.
Subcellular location: Cytoplasm.
Interaction partners:
- Solute carrier organic anion transporter family member.
- UDP-glucuronosyltransferase
Sequence:
MEIPDFSSMKLDSRPELIDFEGVSMTRYFTDNWEKVKNFQARPDDILIATYPKAGTTWVSYILDLLYFGNESPERQTSQPIYMRVPFLEMCFQGLPLGTELADTLPTSPRPIKTHLPVQLVPKSFWEQNSKVVYVARNAKDNAVSYFHFDRMNMGQPEPGDWNTFLQKFMDGRNVFGPWYDHVNGYWKKKQTYSNILYMFYEDMVEDTGREVARLCSFLGLSTSATERERITKGVQFDVMKQNKMTNYSTLPVMDFKISPFMRKGKVGDWRNHFTVAQNEQFDEVYKQKMKNTTVKFRTEI
Protein: Kelch repeat and BTB domain-containing protein 13 (C9JR72)
Organism: Homo sapiens (Human)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21109227, ECO:0000269|PubMed:22542517}.
Interaction partners:
- Troponin T, slow skeletal muscle
- Kelch-like protein 40
- Tropomyosin beta chain
- Tropomyosin alpha-3 chain
- Cullin-3
- Actin, alpha skeletal muscle
- Nebulin
- Cofilin-2
- Leiomodin-3
Sequence:
MARGPQTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEDELLQAVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRDVFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL
Protein: Small ribosomal subunit protein uS19w (40S ribosomal protein S15-5) (Q9FIX6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS26x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS28x
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein eS12z
- Small ribosomal subunit protein eS28z/eS28y
Sequence:
MEPEVVAAGIVKKRTFKKFSFRGVDLDALLDMSIEDLVKHFSSRIRRRFSRGLTRKPMALIKKLRKAKMEAPAGEKPASVRTHLRNMIIVPEMIGSIIGVYNGKTFNQVEIKPEMIGHYLAEFSISYKPVKHGRPGVGATNSSRFIPLK
Protein: Uncharacterized protein (Q387Y7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQSAGSDGEPAACTSAISALQLTNSSAAVLCGEKAPEMSITLLDEIVQFLSPLQLQGYISRIIDVCGTQRVEELILCVRCEKDVENLLGERSSLQQRQNMWKGLCKYKKLAAKRLQQEMRKNVPPKRTRVGVLNPTAGLTGGATTTTSSGIGAPPLRPKPLFDASIGFINRLAFAGYQDSGADLEKQDLPLNVDSFQKTSLELGNGVQDVVAPLQLSLQTLSSLGSSHISLSSPTSSGEKRYRHERVPLVSLCTAGKAGDDPEHGGAVYCGEMWSCSSEEDEGVGAAPTTTSSPERPDSHVKETMELCKAQLDQLRRTLNAAVEEAVSVYNNGLQILQACLKDAVGDVLPGISSIATDEIRVEVLAFTQTPRLRVELHPQEQLCALAPDDAMKATSSETAMKEAPNSPCHNQSCTGPPSVGERGALEEIIADDAPISLPVRAREPSCSSTVVPSNAVGSFHPQVPNACGESNATRKSPQNERNHMFQEISCNEPGAVLENNATVECGEDSCRSVRVSTPTVVAVPSIRNTEATPTSGPGGVRCREAILISSASRTSGSSTALNHVGHVGVSTTPDGNGDCNVVEGAETSEPFDTSPLGEFGLHAIPRPADVRTVLFDSPQWHIVTRQGNEDYSQIIAGSQVIYVDDASSSVTAAVGPKDTTKQFGNVVDAHWNMNKCGVGSPEATTMGGTSLRQRSLSIVEDTMPIQELHDVEQETVCQRQNGLDSYLPLSESSNTTGVVERSLEPYESTTAFELSVMENAGPSSHSQGISGRGSDTNAVEFLDGEHCGNAMAPTRFLTDILTPTTSPRPPGTWSAVETPEKDNSTQINMVEGLMGEDINALDYDTLKDLCGKLGLKVPGDYTFGDCDDESQFIGSAFSHQNDEICDSTGLSGDNGNSCPAHDAVNGAFAVCGGDAGNEETLQQPPHGQKGYTPQLSGLLTRDESENCGKRSAATPPFSMDAEDSEWYDAQRTAKEGQMREVLRLFITRHFFMQDVAAFFLHRLPRFSGGSAYKRLRVSDFLKTRFVLTQGELEEERRVARVKELEEMNCCVLSSLAGDSAERVERQALNFLRNNTASLGDQQLDSSLIFDPNRSSSQVDNADQDELSLYEKLLLMEPTDVHTVTGLVQTDFPHVTRHRVETLMREAGVPIICLQRVHNTQGPADGDVDVTQRPTTPTSPTGSSRTEVTQRNQFHNRKKKFFAQRTLFTRARDR
Protein: Centrosomal protein 112 (A0A8I6G2E2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
LETIFNRIIAELQTTISSLKEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKALQDELETRSNQVRSAEKKLQHKELEAQEQMMYIRQEYETKFKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQSRR
Protein: Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein (Q38ES4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVRVKEKARKGDDAFKTRKQKVGRKKLAPATATRAEVHARTLRVTTPTAITRGILESEAVRTGENCQTHKGEKEKRVVSADQLHRDFKEHLAGTRHYKKVVRSTSFASLTRAVAGHFSAVGRADDSSAMGNETQLSPLEILYAYTGALDAMTDTDDDVRRAALGTLKVILYRRKPAAQIDEQGSGAMEAGGGSATAFNVDQARAALRVVDVTLTHAMVSVRRSGVELLQLILQVQPLSVRAVLSESTTWVKMAGRISSIVLPSTSNGSGNSPSTKMFHVVADLLETMIPLHRSESDAWNQGCPRARHAVDEVVDKQGESNVSLSALVAQFFDECSPRWCVAWKELMELRAALFRDVEWVRHATALARAFACCAMYLWDHRLLGRKNSRLMHHLFTVKVPFTMHELIAPRDPTAESGCGVGNGSKWRVELANAIANACLPLAAANDDTWEVLHNFLSISFHCAKDSDSSDGTSSAGESGKSRRATQLVGPVRTLRTAVVRLHQALLPRLLPIASPLLQIVMQATNLSDSSETDRLALVDVLLMSADVFSSFVTSQVAVQNPQNIRYLRDVVLVVPRFFFALRGLQMEAACLDRIVFSFLYPLWRVVSSGHPLLSSPMPNKLPGGAPSSPQVNKENKQKITALQLLARSLTSLFEIRVPDSGGEGTCRSVAGVLQRCSDRTVELAVHTLFYVGATVPPTSWTRENNVLSLPTLVDTLPRPGVCA
Protein: Intermembrane transport protein YebS (P0AD03)
Organism: Escherichia coli (strain K12)
Function: Component of a transport pathway that contributes to membrane integrity.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:27795327}; Multi-pass membrane protein {ECO:0000269|PubMed:27795327}.
Interaction partners:
- Lipophilic envelope-spanning tunnel protein B
- Intermembrane transport protein PqiB
- Intermembrane transport lipoprotein PqiC
- Ribosomal RNA small subunit methyltransferase F
Sequence:
MALNTPQITPTKKITVRAIGEELPRGDYQRCPQCDMLFSLPEINSHQSAYCPRCQAKIRDGRDWSLTRLAAMAFTMLLLMPFAWGEPLLHIWLLGIRIDANVMQGIWQMTKQGDAITGSMVFFCVIGAPLILVTSIAYLWFGNRLGMNLRPVLLMLERLKEWVMLDIYLVGIGVASIKVQDYAHIQAGVGLFSFVALVILTTVTLSHLNVEELWERFYPQRPATRRDEKLRVCLGCHFTGYPDQRGRCPRCHIPLRLRRRHSLQKCWAALLASIVLLLPANLLPISIIYLNGGRQEDTILSGIMSLASSNIAVAGIVFIASILVPFTKVIVMFTLLLSIHFKCQQGLRTRILLLRMVTWIGRWSMLDLFVISLTMSLINRDQILAFTMGPAAFYFGAAVILTILAVEWLDSRLLWDAHESGNARFDD
Protein: Protein cordon-bleu (D3ZUI5)
Organism: Rattus norvegicus (Rat)
Function: Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates dendrite branching in Purkinje cells (By similarity). Regulates neuron morphogenesis and increases branching of axons and dendrites.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm. Cytoplasm, cytosol. Note=Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites.
Interaction partners:
- Protein kinase C and casein kinase substrate in neurons protein 1
- Protein kinase C and casein kinase substrate in neurons 2 protein
- Protein kinase C and casein kinase substrate in neurons 3
Sequence:
MKARAPPPPGKPAAQNVHSEQKLPHDATLGSQQSLVHLKEALHNSTLDITVVLPSGLEKQSVVSGSRAVMDLLVELCLQNHLNPSHHVLEIWSSETQQPLSFKPNTLIGSLNAHTVFLKEKVPEEKGKPGLTKAPEKSVRLVVNYLRTQKAVMRVSPEVPLQNILPVICAKCEVSPDHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRREMLRKSSLGNDETDKEKKKFLGFFKVNKRSNSKAEHLGLSGADSDEDPSKSASGGDLNGCVTTPNSPSLHSRSLTLGPSLSLGNISGMSMKSDMKKRRAPPPPSPGLLGQDKVSEKASLSSQADLQKKKRRAPAPPPPQPPPPSPVVPNRKEDKEENRKSTVGMEENYETDTSSLTSSVNGVSNHSLQEAIIPDSGVDDIPVTFIGEVSDEPFDSGLFFSGSNNAAALNQGGIASQRSHLPPYQTEQSQPFIRTNRKEPDPSLPSQDYRKRNQPILANTSENENPVGIDPRVTSFVSKPSTDDPKAKDKDKMCGSGPSEKTQTGHRVNSLPVNPRVGEDENSNSALPPWSHHGQASGGSYGLKYGLTTYKIVPPKPEMRCYDRDVSLSTGAIKIDELGNLMSPHMNGSRTISKPSAVAETEAPPIGKVKEFWRRNSMEKYLNGPAECTVKKAPSTTITATSEKPQRDETKAGFTLTTPEQQPASQEYGAPPEEDRSRPHSAVSCPVKVPAPNPTDITFLKPQRRTSSQYVASAIAKKMGPPKVHADVVRPHKKTAEQGHEEAKLARPPPAWKDSAVPNLCSEAGQCEHGTNQGSVRLPSNPGGQLPADHPKVEVNSTYGKSATHNSPAAVHRNSYFLPGRSSQRDRVSVGQSCGFHEKQTISNQKMNSTSNPSQALDKAHPAPLLLTEARDSGRILVNGSAQTPGNCEPPHSQKESTLTSYIILQTEEKPSPLSADGQNSDDALPSSIFGPKKKFKPVVQRPLPKDISLHSALMEAIHTSGGRDKLRKTAEQASEGRPKKPSYVEAESERSALLAAIRGHSGTLSLRKVSSLASEELQSFRDAALMAPGVDKPQQEDRGLPPPPALPPPSTPASQVPSASIPVSRFSIGTLSNPVNARQALMDAIRSGTGAARLRKVPLLV
Protein: 14-3-3 protein zeta (Q5ZKC9)
Organism: Gallus gallus (Chicken)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P63104}.
Interaction partners:
- RAF proto-oncogene serine/threonine-protein kinase
- Cell division cycle 25B.
- 14-3-3 protein epsilon
- Catenin beta 1
- Serine/threonine-protein kinase B-raf
- BH4_AAA_HYDROXYL_2 domain-containing protein.
- Microtubule-associated protein.
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Tryptophan 5-hydroxylase 1
- Tryptophan 5-hydroxylase 2
Sequence:
MDKNELVQKAKLAEQAERYDDMASCMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVEQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
Protein: Sexual differentiation protein ste4 (P36622)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for mating and meiosis.
Interaction partners:
- Protein kinase byr2
- Ras-like protein 1
- Transcription factor ste11
- Protein ste7
- Guanine nucleotide-binding protein alpha-1 subunit
- Protein ste6
- GTP-binding protein rhb1
Sequence:
MGDSDDFYWNWNNEAVCNWIEQLGFPHKEAFEDYHILGKDIDLLSSNDLRDMGIESVGHRIDILSAIQSMKKQQKDKLQQENKDQELKNIEESYKKLEEKTEHLSDDNVSLEKRVEYLETENTKLVKTLNSLNSEFLQLLRKIAINVKEGRQLTTENSSDTSSMTHPVQPSPSVLGSFDLEVNDSLTNAEKNRKLNVNLTYNEVLCSMLQRYRIDPNTWMSYDLLINYDDKEHAIPMDVKPLQLFRNLQKRGKSPSFVLSRRSC