wanglab/gogpt-training-data huggingface dataset:
Protein: Coiled-coil and C2 domain-containing protein 2A (Q8CFW7)
Organism: Mus musculus (Mouse)
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21725307}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21725307}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Interaction partners:
- Tectonic-1
- B9 domain-containing protein 1
- B9 domain-containing protein 2
- Tectonic-2
- Jouberin
- Transmembrane protein 231
- Transmembrane protein 216
- Meckelin
- Tectonic-3
- Centrosomal protein of 290 kDa
Sequence:
MNTNDEKMKIISEDFTGDGVDTEAGRRKKNSKVRRQQRKKKPPASPPEEMVSDKFQDGGQQEVVEEEPETNLLSLTARRGPRSLPPIPSASRTGFAEFSMRERMREKLQAARSKAESALLRDVPTPRPRRLRSPSREKETETEFGTEPSTEVQDTQKEDDTKSYSRIKFRDSVRKIKSKPQLPPGFPSAEEAYNFFTFNFDPEPEESEEKSPVKGGERAHHEDQEGEEGTQAQERAKKTEEEELLNGKDAEDFLLGLDPTAHDFVAVRAAEYKSARIQLQKEKEILFTPSRLTVPTYKKLPENIQPRFLEDEGLYIGARPEVARTNENIMENRLLIQEPGSKWFGDDGRILALPSPIKPFPSRPSLTTREQSPKAGLETLYKKAEKYVHSRQHMIGSGDPPGNFQLDIDISGLIFTHHPCFSREHVLASKLAQLYDQYLARQQRNKTKFLTDKLQALRKAVQTSLNPEKPHQSLDTTQKTINEYKSEIRQTRKLRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKVDPKLDEDAYEAEIQAEIHELLEEHMEEYATKMEEYRTSHQQWKAWRKAQRAKKKKKKQTTEEHLEEEEAEESFPEEEVTKPIPPEPTDPAVIEQQVRERAAHSRRRPGEPTLIPELSLAGNVTPNDQCPRVEVSRREDVRRRSVYLKVVFNSKEVSRTVSRPLGADFRVHFGQIFNLQIFNWPESLMLQVYETIGHSGTTLLAEVFLPIPETTLVTGRAPIEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAVGENGIPLIPPLSQQNIGFRSALRRADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNHAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSEEELNRSKRFRLLHLRSQEVPEFRNYKQIPAYDREIMEKVFQDYEKRLRDRNVIETKDHLDMHRATVAKYLQQVREAVVNRFLTAKHHFLLTDLVVEEEVPNISSEGSGILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIIRAYDIPVRKPVVSKFQQPSRSSRTFSEKQTASPSTHSPLHNADYPLGQVLVRPFVEVSFQRTICHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQSVKDDVYINIFDEVLYDILEDDRERGSGIHTRIERHWLGCVKIPFSTIYFQARIDGTFKIDIPPVLLGYSKERNIIMERAFDSARSLSEGSYITLFITIEPQLVPGEPMREKMSDMLKKFDTQEDEKLLQATEKFQAECALKFPQRQCLTTVTDMTGKTVFITRYLKPLNPPQELLHVYPNNPQATAELVARYVSLIPFLPDSVSFAGVCDLWSTSDQFLDLLAGDEEEHAVLLCNYFLFLGKKAWLVMGSAIPEGPTAYVLTWEKNYYLIWNPCSGHCYGQFDAFCPLKSVGCLIGPDNIWFNIQHHDSPLRINFDVTKPKLWKSFFSRSLPYPGLSSVQPEELIYQHTDKAVAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLERSQGEDIEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLVEAVYSTGVHNIDLPNVEFALAVYIHPYPKNVLSVWIYVASLVRNR
Protein: Probable argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) (P50514)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Argininosuccinate synthase
- Protein arg11
- Argininosuccinate lyase
- Adenylosuccinate lyase
- Ornithine carbamoyltransferase, mitochondrial
- Amino-acid acetyltransferase, mitochondrial
- Arginase
- Arginase
- Probable citrate synthase, mitochondrial
- Arginine biosynthesis bifunctional protein ArgJ
Sequence:
MASSQKLWGGRFTGATDPLMTAYNESIHYDKRMFNADIDGSKAYAKALEQRGIISADELDKMLDGLEAVRDEWKTNKFTLQPSDEDIHTANERRLGEIIGTGIAGKLHTGRSRNDQVTTDMRLWLRDELDIIQKSLVGLLQVFVARAESDLDIIMPGYTHLQRAQPIRWSHFLLSHAFSILNDLDRLKQIYSRVNRLPLGAGALAGNPFAVDRKFLQKELGFEGVIMNSMNAVADRDYVIEFMFWASMVMTHISRLAEDLIIYSTSEFNFVTLSDAYSTGSSIMPQKKNPDSLELLRGKSGRVFGNMMGFMVSVKGIPSTYNKDLQEDKEPLFDSSKTVLDSIQILTGVLSTLTVNPENIAKSLTADMLATDLAEYLVRKGVPFRETHHISGSAVRMAEERNTTIDKLSVEDFKSLHPLYEEDVADVFNYESSVEKRCAIGGTAKSCVLEQIQTIKKALE
Protein: Gap junction protein (E9PTP3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}.
Interaction partners:
- Gap junction alpha-5 protein
- Gap junction alpha-1 protein
- Gap junction gamma-1 protein
- Gap junction beta-2 protein
- Gap junction alpha-4 protein
- Gap junction beta-4 protein
- Gap junction alpha-8 protein
- Gap junction alpha-3 protein
Sequence:
MGEWAFLGSLLDAVQLQSPLVGRLWLVIMLIFRILVLATVGGAVFEDEQEEFVCNTLQPGCRQTCYDRAFPVSHYRFWLFHILLLSAPPVLFVIYSMHQASKEAGGAQPAPPCARGRAEVPCSPCALRARRARRCYLLSVALRLLAELAFLGGQALLYGFRVAPHYACAGPPCPHTVDCFVSRPTEKTVFVVFYFAVGLLSALLSVAELGHLLWKGRQRAKLLPPPPPSPSLPSQRGDPDPFGPPAYAHRSPAGDSEGEGGSGHSKASLATVRQDLAI
Protein: Probable secreted beta-glucosidase SIM1 (EC 3.2.1.-) (P40472)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions. Required for the maintenance of the CLB5 kinase activity.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:11958935, ECO:0000269|PubMed:24040106}. Note=Non-covalently bound to the cell wall.
Interaction partners:
- Uncharacterized protein YGL188C-A
- Probable secreted beta-glucosidase UTH1
- Uncharacterized protein YKL068W-A
Sequence:
MKFSTAVTTLISSGAIVSALPHVDVHQEDAHQHKRAVAYKYVYETVVVDSDGHTVTPAASEVATAATSAIITTSVLAPTSSAAAADSSASIAVSSAALAKNEKISDAAASATASTSQGASSSSSSSSATSTLESSSVSSSSEEAAPTSTVVSTSSATQSSASSATKSSTSSTSPSTSTSTSTSSTSSSSSSSSSSSSSSSGSGSIYGDLADFSGPSEKFQDGTIPCDKFPSGQGVISIDWIGEGGWSGVENTDTSTGGSCKEGSYCSYSCQPGMSKTQWPSDQPSDGRSVGGLLCKNGYLYRSNTDADYLCEWGVEAAYVVSKLSKGVAICRTDYPGTENMVIPTYVEGGSSLPLTVVDQDTYFTWEGKKTSAQYYVNNAGVSVEDGCIWGTSGSGIGNWAPLNFGAGSTGGVTYLSLIPNPNNSDALNYNVKIVAADDSSNVIGECVYENGEFSGGADGCTVSVTSGKAHFVLYN
Protein: Nuclear poly(A) polymerase 4 (AtPAP(IV)) (PAP(IV)) (Poly(A) polymerase IV) (nPAP) (EC 2.7.7.19) (Polynucleotide adenylyltransferase 4) (Q8VYW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein. Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:19956626}.
Interaction partners:
- Polyadenylate-binding protein 1
- FIP1[V]-like protein
- FIP1[III]-like protein
- Polyadenylate-binding protein 3
- Polyadenylate-binding protein 2
- Probable galacturonosyltransferase-like 4
- Nuclear poly
- Symplekin
- HEAT repeat-containing protein
- Cleavage stimulation factor subunit 77
Sequence:
MMVGTQNLGGSLPPLNSPKSYGITKPLSLAGPSSADIKRNVELEKYLVDEGLYESKDDTMRREEVLGRIDQIVKHWVKQLTQQRGYTDQMVEDANAVIFTFGSYRLGVHGPGADIDTLCVGPSYVNREEDFFIILHDILAEMEEVTELHPVPDAHVPVMKFKFQGIPIDLLYASISLLVVPQDLDISSSSVLCEVDEPTVRSLNGCRVADQILKLVPNFEHFRTTLRCLKYWAKKRGVYSNVTGFLGGVNWALLVARVCQLYPNAIPSMLVSRFFRVYTQWRWPNPVMLCAIEEDELGFPVWDRRKNHRDRYHLMPIITPAYPCMNSSYNVSQSTLRVMTEQFQFGNNILQEIELNKQHWSSLFEQYMFFEAYKNYLQVDIVAADAEDLLAWKGWVESRFRQLTLKIERDTNGMLMCHPQPNEYVDTARQFLHCAFFMGLQRAEGVGGQECQQFDIRGTVDEFRQEVNMYMFWKPGMDVFVSHVRRRQLPPFVFPNGYRRPRQSRHQNLPGGKSGEDGSVSHSGSVVERHAKRKNDSEMMDVRPEKPEKRASLSPQSLDIVSPENSAITTGWTPPVCNLRRPPSEEIEADNLNTECTELTDLARNECNSGSEQVLEVDSMAVVQECSDPAEPLGKCVTPDSVDVVACVSGQEENLDRNLRSVSISGTDSPLLPSRSCGQNRDYEGFGFPAANSDPMGKKNLYSQSGMSEDLQSNSLVSGMEKSEDRARSESFQKSQIRLLT
Protein: Early growth response protein 1 (EGR-1) (Zinc finger protein ZENK) (O73691)
Organism: Gallus gallus (Chicken)
Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity). Plays a role in regulating the expression of circadian clock genes (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P18146}. Cytoplasm {ECO:0000250|UniProtKB:P18146}.
Interaction partners:
- Mitogen-activated protein kinase.
- Protein c-Fos
- FosB proto-oncogene, AP-1 transcription factor subunit.
- Transcription factor Jun
- BRICHOS domain-containing protein.
Sequence:
CDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKVEKAASVSATSSSVAAYSSSVATSYSSSIATTYPSSVRTVYSSPASSSYPSPAHTTFPSPSIATTYSSGTATFQTQVATSFPSPGVTNNFSSQVTSALSDMTSTFSPRTIEIC
Protein: At3g03650 (Exostosin family protein) (Glycosyltransferase) (T12J13.7 protein) (Q9SS65)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Interaction partners:
Sequence:
MGEKTNSRYLGVIITRKSIIFLFISIITVLSWFFIFSSTNPNRVLDHISVSESTDVPLIIIKNSNSSPQNNAPKPQNREGAETEEPIKENRGGTKTESSMNQNRGETLRCIQRVSPSPRPLKVYMYDMSPEFHFGLLGWKPERNGVVWPDIRVNVPHHPGGLNLQHSVEYWLTLDLLFSELPEDSRSSRAAIRVKNSSEADVVFVPFFSSLSYNRFSKVNQKQKKSQDKELQENVVKYVTSQKEWKTSGGKDHVIMAHHPNSMSTARHKLFPAMFVVADFGRYSPHVANVDKDIVAPYKHLVPSYVNDTSGFDGRPILLYFQGAIYRKAGGFVRQELYNLLKEEKDVHFSFGSVRNHGISKAGEGMRSSKFCLNIAGDTPSSNRLFDAIASHCIPVIISDDIELPYEDVLNYNEFCLFVRSSDALKKGFLMGLVRSIGREEYNKMWLRLKEVERYFDLRFPVKDDEGDYAVQMIWKAVARKAPLVKMKVHRFQRFTRPF
Protein: Expressed protein with apparent function in citronellol catabolism (Q9HZW1)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Peroxisomal trans-2-enoyl-CoA reductase
- Geranyl-CoA carboxylase, beta-subunit
- Citronellyl-CoA dehydrogenase involved in catabolism of citronellol
- Isohexenylglutaconyl-CoA hydratase
- Short chain dehydrogenase involved in catabolism of citronellol
- Biotin carboxylase
- Repressor of atu genes
- Very-long chain acyl-CoA synthetase
- Methylcrotonyl-CoA carboxylase, beta-subunit
- Regulator of liu genes
Sequence:
MQKTVRIGCASAFWGDTCTAAAQLVRGAPLDYLVFDYLAEITMSIMAGARLKQPDAGYATDFVEVLAPLLGEIAEKKIRVISNAGGINPQACAAALAAACEKAGVQLKIAVLHGDNLQARQAELAKSGIREMFSDAPFPPMCVSLNAYLGAPGIVEALRLGADIVITGRVVDSAVVSAALVHEFGWAWDDYDRLAQAALAGHIVECGAQCTGGNFTDWEQVPDYEHIGFPIVEVEADGRFVVTKAPGTGGLVSELSVGEQMLYEIGDPRAYLLPDVVCDFTEVRLRQAGPDRVAVEGARGLPPTDRYKVSATYPDGFRCTASCLIAGIDALKKAERVSQAIIARTEEIFAEHGWEPYREVNVELLGSEATYGPHGRRQDSREVVVKLAVRHPRKEALVLFSREIAQAATGMAPGLTGIVGGRPTVYPVIRLFSFLIDKAQCALSVEIDGQRHPLELPVLEAFDPARLAEARQPPRPEQPASASVPLLKLAVARSGDKGNHSNIGVMARRPEYLPWIAEALEEGAVVDWMQHVLDPQTGRVGRWYLPGSHSLNFLLENALGGGGVASLRIDPQGKAFAQQLLEFPVAVPQALADALETQGR
Protein: Beclin-2 (Beclin-1 autophagy-related pseudogene 1) (Beclin-1-like protein 1) (A8MW95)
Organism: Homo sapiens (Human)
Function: Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Phosphoinositide 3-kinase regulatory subunit 4
- Apoptosis regulator Bcl-2
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Beclin 1-associated autophagy-related key regulator
- Bcl-2-like protein 1
- Serine/threonine-protein kinase ULK1
- Serine/threonine-protein kinase ULK2
- UV radiation resistance-associated gene protein
- Beclin-1
- High mobility group protein B1
Sequence:
MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQDGASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKAAGDIFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLANTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQFKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKWSLIWVASRYQK
Protein: Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] (P18509)
Organism: Homo sapiens (Human)
Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Vasoactive intestinal polypeptide receptor 1
- Pituitary adenylate cyclase-activating polypeptide type I receptor
- Vasoactive intestinal polypeptide receptor 2
- Secretin
- Gastric inhibitory polypeptide receptor
- Glucagon-like peptide 1 receptor
- Follicle-stimulating hormone receptor
- D
- Beta-1 adrenergic receptor
- 5-hydroxytryptamine receptor 6
Sequence:
MTMCSGARLALLVYGIIMHSSVYSSPAAAGLRFPGIRPEEEAYGEDGNPLPDFDGSEPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL
Protein: Enhanced adult sensory threshold, isoform B (Enhanced adult sensory threshold, isoform C) (Enhanced adult sensory threshold, isoform D) (Q7KW02)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSRKVPGGSGGADESTAAAAPLDDNANASVEIPDSSEEPAMGVGEEMSIISKTRTSTLSVEPAKEPTVTAELEGEKELESNPVSKTPRSTPTPTLTPAVTPTASDGVAAKSVRVTRHSSPLLLIISPTTSRREVGDGELDTEEPTGSGGQRKSSVERSLAPVIRGRKSIKDLKEAKEVKSEEPPAAASESRAASGVTPGQVKEQHVADGNEMESLPITDKKDHKDTKDKGDERETDQEEEKEKSADTEIIADTEKTSEKQKYTEKDKAADKDGGKEKDIDANKDIDKEKEKVKEVLPPVVPIAPVTPTCNRVTRKSHAQEQAINTRVTRNRRQSSTVGANSTASLVAASSSVTEQPPPSRGRRKKPVVVAPPLEPAVKRKRSQDVEADSDANNSTKYSKVEVVKSEEAEAPEEDSSAVPIKQESVDGNEVSSISPTVTPTPTPAPTPAPVPGSRRGRGRPQNRNSSSPATTTRATRLSKAGSPVILTPVAQEPAPPKRRRVGSSTRKTVSASSLAPSSQGGAGDEDSKDSMASSMDDLLMAAADIKQEKLTPDFDDSLMPEGLPSTSGASSANGHSCTEPLTVDTEINVKPADSKVKPKESPVVAVEESPSQSETQSAKVSAHAGKAPSLSPDMISEGVSAVSVRKFYKKPEFLENNLGIEKDPELGEIVQTVSNNDTETDVEMAVDGEVNQPSTPKSQDKKKEEQEKNQKSGLKAAKKAPAKLEPKAEDISEILTDVPVDISTEAVEIIEEAEEDTCSNSSIKPGELRLDESNDEPELLLEDALIVNGDENETPDQPEEKEDQVEFFHTGEYDDFEHEIMVELAKEGVLDASGNALSQQKVELEHPEDVTLHESKNDIEAEESVERKPLKDPSVADEMEDMNEESYIDIKDQTNQLLVEHLAEEAMEADCGPEDNKENLSTSASSTAADGLDIQLAIKEDDDEEKPLAVIADEQKPGLLLTNDMKVDEKPNGKQESVCDEHVQLVPNLRQEQEIHLQNLGLLTHQAAEHRRKCLLEAQARQAQMQLQQHHHHQHKRQGARGGGSATHVESSGTLKTVIKLNRSSNGGVSGSGGLPTGTVIHGGCGSSSASSTSSSSVGSATRKSSGTLGSGAGAGAGVRRQSLKMTFQKGRARGHGAADRSADQYGAHAEDSYYTIQNENEDSSHSESQGQTDHGFYQMVKKDEKEKILIPEKASSFKFHPGRLCEDQCYYCSGKFGLYDTPCHVGQIKSVERQQKILANEEKLTVDNCLCDACFRHVDRRANVPSYKKRLSASGHLEMGSAAGSALEKQFAGDSGVITESGGEAGSTAAVAVQQRSCGVKDCVEAARHSLRRKCIRKRVKKYQLSLEIPAGSSNVGLCEAHYNTVIQFSGCVLCKRRLGKNHMYNITTQDTIRLEKALSEMGIPVQLGMGTAVCKLCRYFANLLIKPPDSTKAQKAEFVKNYRKRLLKVHNLQDGSHELSEADEEEAPNATETERPTSDGHEDPEMPMVADYDGPTDSNSSSSSTAALDTSKQMSKLQAILQQNVGADAAGAAGTGTVAASPGGSGSGADISNVLRGNPNISMRELFHGEEELGVQFKVPFGCSSSQRTPEGWTRVQTFLQYDEPTRRLWEELQKPYGNQSSFLRHLILLEKYYRNGDLVLAPHASSNATVYTETVRQRLNSFDHGHCGGLNIAGSPSSSGSGKRSGVPQPTGASVLATALTTPLTSHSSSSASISSEQHSSVDPVIPLVDLNDDDEGEDGAGGAGERESTNRQQDVILECLRTASVDKLTKQLSSNAVTIIARPKDKSQLSCNSGSSTSISSSSSAISSPEEVAVTKVTAVAPVQSKDAPPLAPASSGVSNSRSILKTNLLGMNKAVELVPLTTAPHAYKPTGCHKPEKQQKILDVANKQPGSQGEPVPSSALLGLQSKLKPPTHQQQVSGSGAGTSGSQKPSNVAQLLSSPPELISLHRRQTSGAAAGSSSFLQGKRLQLPRSGAGPSGAGTGTGAGAAGSRSAGGPPPPNVVILPDALTPQERHESKSWKPTLIPLEDQHKVPNKSHALYQTADGRRLPALVQVQSGGKPYLISIFDYNRMCILRREKLMRDQLLKSNAKPKPQNQQQQQGQTHQQQQNSAASAAAFSNMVKLAQQHTARQQLQQLQQKPQQQQQLPTLQPGGVRLARLPQKLLMPPLTNPQIGSQAPNLQPLLSSTLDNSNNCWLWKNFPDPNQYLLNGNGGGAGSSSSKLPHLTAKPATATSSSGAANKSAGSLFTLKQQQHQQKLIDNAIMSKIPKSLTVIPQQMGGNTGGDMGGSSSSGKD
Protein: Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog) (Progression elevated gene 3 protein) (PEG-3) (Q6IN02)
Organism: Rattus norvegicus (Rat)
Function: Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux.
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:O75807}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:O75807}. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000250|UniProtKB:O75807}.
Interaction partners:
- Eukaryotic translation initiation factor 2 subunit 1
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Cyclic AMP-dependent transcription factor ATF-4
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome c oxidase subunit 1
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 4
Sequence:
MAPSPRPQHVLHWKEAHSFYLLSPLMGFLSRAWSRLRGPEVSEAWLAETVAGANQIEADALLTPPPVSENHLPLRETEGNGTPEWSKAAQRLCLDVEAQSSPPKTWGLSDIDEHNGKPGQDGLREQEVEHTAGLPTLQPLHLQGADKKVGEVVAREEGVSELAYPTSHWEGGPAEDEEDTETVKKAHQASAASIAPGYKPSTSVYCPGEAEHRATEEKGTDNKAEPSGSHSRVWEYHTRERPKQEGETKPEQHRAGQSHPCQNAEAEEGGPETSVCSGSAFLKAWVYRPGEDTEEEEDSDLDSAEEDTAHTCTTPHTSAFLKAWVYRPGEDTEEEDDGDWDSAEEDASQSCTTPHTSAFLKAWVYRPGEDTEEEDDSENVAPVDSETVDSCQSTQHCLPVEKTKGCGEAEPPPFQVAFYLPGQKPAPPWAAPKLPLRLQKRLRSFKAPARNQDPEIPLKGRKVHFSEKVTVHFLAVWAGPAQAARRGPWEQFARDRSRFARRIAQAEEQLGPYLTPAFRARAWTRLRNLPLPLSSSSLPLPEPCSSTEATPLSQDVTTPSPLPSEIPPPSLDLGGRRG
Protein: Probable serine/threonine-protein kinase mkcA (EC 2.7.11.1) (MAP kinase cascade A) (Q54MY9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Coordinates organism morphology with cellular differentiation during development. Negative regulator of sporulation, synchronizing encapsulation with culmination. May have an additional function in prestalk cells.
Interaction partners:
Sequence:
MDNNSTLNNITITVASSHNNTTTNSNNNNNNNNGSNSNNNNEQLNTLSNSITSLKSLNISGSGVITNNSEVNTPSEGNITPLPLLSLSDALSPLRELYSCLYVGDIRALMSNQYLKFEENEKIRILGFPEPHLEIDEKTQKYFSYQIIEFESDEDILSIAKSFEQYSQLILGRTPTQPVVIQECCFGLVLASIYFIKYELFSLPQAHDLIGYNDFFGTSKKHSHFEKVDSCTLINDITSYYYNNMSSKRKTTIFSNNISFTNLQTTTPPTTTTTTTTTTTTSSSNNSEQIESTSKNNSSGITSPTSIKPKNKVGLLKKLFNKMDKESSNNNNNKEKVEKIKEKKESKKEREAREAKEEKEREEREKEHQLALKNIPPAELYKHHMEQIQKIQKQQIAELNATSPDGGNDLSNGSNGSKNGNNNNNNNNSNNNNNNNNSNEPNSQHQNHNPITNLMDQELIENYDDGSDRMKNSKTIISPNFESLPDEYKTMVKTWDIKQESVDEHFEIILSLLHFHTKQRFYSSDPTNLPDKPKYYNVGNVCGNCTPPMILDPAGSGQMVVAKSFYKRPFDQICKKPTNEMKKLYTFREKVGKGGFGTVYLVRNNMDKSKSRIAIKKLPHVRKKEKKFNVKEIRVLEFTNHPNIITYYNSHMLHDEVWIAMEFMEGGTLAEASNQYPFQESNIAYVAREVLQGLAYLHGIQLVHRDLKSQNIMMTTSGEIKLIDFGLCANLSKGERIRMCGSPIWMPPEMIQQKQHGYTCDIWSTAICLLELANRNNKLRKNPIKTMFMVGSEGIKDPFEDPHKWSDEFHDIINKCLQMDPHKRPSAQELLKHPFIQLADNKKKMGKILSSIFLKSIVGI
Protein: Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (P17108)
Organism: Rattus norvegicus (Rat)
Function: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
Subcellular location: Secreted.
Interaction partners:
- Interleukin-2 receptor subunit beta
- Interleukin 2 receptor, gamma, isoform CRA_a.
- Interleukin-2 receptor subunit alpha
- Interleukin-4
- Granulocyte-macrophage colony-stimulating factor
- Tyrosine-protein kinase JAK3
- Interleukin-5
- Interleukin-1 alpha
- Interleukin-6
- Interleukin-3
Sequence:
MYSMQLASCVALTLVLLVNSAPTSSPAKETQQHLEQLLLDLQVLLRGIDNYKNLKLPMMLTFKFYLPKQATELKHLQCLENELGALQRVLDLTQSKSFHLEDAGNFISNIRVTVVKLKGSENKFECQFDDEPATVVEFLRRWIAICQSIISTMTQ
Protein: DNA repair protein (Q389E0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTAEEISQRLALLTSQTILQHDLNRRFTQHAVFSTGSEELDRLLPDGGMTCGTVLEVFGPPSGGKSRLVRRMISSFAAQGALEWTTRGVDVGICDGSPSKGLEVQQECLRARAEECCRPREWCVFYVLSDPSSLNPRHLREELEKALQRAMLCDVHCEGEIERLLDDIIGRVQVVNFATLNDLLNFFRFLYHEEYPSSMHHANQRRALVVIDSVARLWDHPTCGATKHARHWAAAELVRELRNVIMLGNGWRGEYCGNIDSHHLDTEAGNVFCSVQAANAGTSVGGSVAVVLVNGCTNTRYCHTVVGPLGVPLWLAAAADIRLFIEPTSTSGDYPPTTGEDDDGMLCTHQYGAAKHVLAVRVAKGSGSSVPRVGNIFLP
Protein: Sporulation-specific protein 21 (Meiotic plaque component protein 70) (Q12411)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May provide a meiosis-specific scaffold for the assembly of other proteins on spindle pole bodies (SPBs), and may be a limiting component for SPB formation.
Subcellular location: Prospore membrane. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the ends of spindle microtubules in cells in meiosis.
Interaction partners:
- Sporulation-specific protein 74
- Meiotic plaque component protein 54
- Accumulates dyads protein 4
- Accumulates dyads protein 3
- Chaotic nuclear migration protein 67
- Donuts protein 1
- Prospore formation at selected spindle poles protein 1
Sequence:
MDNILKASNMEGTSTMTVTSRSSEDSSCISNHEQDTDTHKDGDTSGLENSKISKRKWMKEFFKLSKSPASKSSRSIGSMKSNQSLVSMKSSDDGNSYKNDYSSICGNSLPSAGLSRSNSVKELKLDSTGSQRSKNNVAMLARSSTTSQTTCSSSSSSSSYNSIKGNENDILLQNNNHFRHNKEIPQSKGSSNINTASIMSQYNVDTQATAIMSDMQKQYDSQQMTSPFVNEDLHFDPNGEVSHVIKAIFKEIGYKYDDFSDIPVFQLMQEMYQLVKKNSSARRTKITDYASKLKEKEAQLKSQNDKILKLETTNKAYKTKYKEVSLENKKIKEAFKELDNESYNHDEELLKKYKYTRETLDRVNREQQLIIDQNEFLKKSVNELQNEVNATNFKFSLFKEKYAKLADSITELNTSTKKREALGENLTFECNELKEICLKYKKNIENISNTNKNLQNSFKNERKKVLDLRNERNLLKKEILLIECHGSYSLLLVSNILTCYRFLLPSDTIIETESLIKELLNMNNSLSNHVSSSDEPPAEYSKRLELKCVEFEEKLLYFYQELVTKKIIDVIYKCFINYYKKSRQTDQKSNQNSSTPYKQSQRQVPHSIK