wanglab/gogpt-training-data huggingface dataset:
Protein: 5-oxoprolinase subunit C (5-OPase subunit C) (EC 3.5.2.9) (5-oxoprolinase (ATP-hydrolyzing) subunit C) (P75745)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
Interaction partners:
- 5-oxoprolinase subunit A
- 5-oxoprolinase subunit B
- GTP cyclohydrolase 1 type 2 homolog
- Endonuclease 8
- Biotin carboxylase
- Glutamate--cysteine ligase
- Glutathione-specific gamma-glutamylcyclotransferase
- Glutathione hydrolase proenzyme
- Putative glutamate--cysteine ligase 2
- Glutamate synthase large chain
Sequence:
MLKIIRAGMYTTVQDGGRHGFRQSGISHCGALDMPALRIANLLVGNDANAPALEITLGQLTVEFETDGWFALTGAGCEARLDDNAVWTGWRLPMKAGQRLTLKRPQHGMRSYLAVAGGIDVPPVMGSCSTDLKVGIGGLEGRLLKDGDRLPIGKSKRDSMEAQGVKQLLWGNRIRALPGPEYHEFDRASQDAFWRSPWQLSSQSNRMGYRLQGQILKRTTDRELLSHGLLPGVVQVPHNGQPIVLMNDAQTTGGYPRIACIIEADMYHLAQIPLGQPIHFVQCSLEEALKARQDQQRYFEQLAWRLHNEN
Protein: Apolipoprotein M (Apo-M) (ApoM) (Protein Px) (P14630)
Organism: Rattus norvegicus (Rat)
Function: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity).
Subcellular location: Secreted. Note=Associated with HDL.
Interaction partners:
- Beta-2-glycoprotein 1
- Apolipoprotein A-II
- Apolipoprotein C-III
- Apolipoprotein C-I
- Apolipoprotein C-II
- Serum paraoxonase/arylesterase 1
- Apolipoprotein B-100
- Apolipoprotein C-IV
- Clusterin
- Phosphatidylcholine-sterol acyltransferase
Sequence:
MFHQVWAALLYLYGLLFNSMNQCPEHSQLMTLGMDDKETPEPHLGLWYFIAGAAPTMEELATFDQVDNIVFNMAAGSAPRQLQLRATIRTKNGVCVPRKWTYHLTEGKGNTELRTEGRPDMKTDLFSISCPGGIMLKETGQGYQRFLLYNRSPHPPEECVEEFQSLTSCLDFKAFLVTPRNQEACPLSSK
Protein: Unconventional myosin-Id (Myosin 1d) (Myosin1D) (E7F9L8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in the formation of Kupffer's vesicle, an organ that functions as left-right organizer during embryogenesis. Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle. Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric development. Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q63357}. Perikaryon {ECO:0000250|UniProtKB:Q63357}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63357}. Early endosome {ECO:0000250|UniProtKB:F1PRN2}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q63357}. Note=Colocalizes with the actin cytoskeleton in the cell cortex close to the apical cell membrane. Colocalizes with cytoplasmic puncta that are reminiscent of transport vesicles. {ECO:0000250|UniProtKB:Q63357}.
Interaction partners:
Sequence:
MAEHESLEFGKADFVLLDNVSLEEFMANLKLRFEKGRIYSYIGEVVVSVNPYRAMNIYGRDVIEQYKGRELYERPPHLFAIADAAYKAMKRRNKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIFQQEGERSFHSFYQLVKGAPDAQLRSLHIQRDPTAYNYIKVGGQLKSSINDSAEFKAVADAMKVIGFTTEEIQTVYKILATILHLGNLKFGTDGDVTLIENSKLVSVLGDLLSTKEENVEKAMLYRTVATGRDVIDKQHTHQEASYGRDALAKAIYERLFCWIVGRINDIIEVKNYDARVHGKNTVIGVLDIYGFEIFQNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIFAVLDEACMNVGKVTDEMFLQALNGKLAKHAHYTSRKLSPTDKNLEFERDFRIRHYAGDVTYSVVGFIDKNKDTLFQDFKRLLYNSSNPVLKAMWPEGKLSITEVTKRPLTAATLFKNSMISLVEKLASKEPYYVRCIKPNDVKSPLLFEHERCKHQVEYLGLLENVRVRRAGFANRQTYPRFLQRYKMISEFTWPNHDLSSDKEAVKRLLQGCGFEHDVAYGKTKVFIRTPRTIFSLEEQRAEMVKRIVLFLQKVWRGTLARMRYRRMRAALIIIRAYRRYKVKSYIREVIRRFKNVRDMKDHGKHVKWPTPPKVLRKFEEALRSIYNRWWAWTLIKPLSPEKTVQIRAKVATLECLKGQRADLGLQRAWEGNYLKKDSPGTASSFTLVSSDLQRKDKFMRVLFSSNVRKINRFNKAEDRALLITDRHLYKMDPLKQYKPMKSIPLYNVTGVSISPGKDQLVVFHTKDNRDLIVCLQGMVPAGDSRIGELVGTLLSHFKSEKRKLQVNTVSPIHCSMNGRKCTVVVETKISQSQPDFTKSRSGYILSVPGN
Protein: Uncharacterized Nudix hydrolase NudL (EC 3.6.1.-) (P43337)
Organism: Escherichia coli (strain K12)
Function: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Interaction partners:
- Aminodeoxychorismate synthase component 1
- UPF0047 protein YjbQ
- Low specificity L-threonine aldolase
Sequence:
MEYRSLTLDDFLSRFQLLRPQINRETLNHRQAAVLIPIVRRPQPGLLLTQRSIHLRKHAGQVAFPGGAVDDTDASAIAAALREAEEEVAIPPSAVEVIGVLPPVDSVTGYQVTPVVGIIPPDLPYRASEDEVSAVFEMPLAQALHLGRYHPLDIYRRGDSHRVWLSWYEQYFVWGMTAGIIRELALQIGVKP
Protein: Rootletin-like coiled-coil domain-containing protein (H2L0I4)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSDPQVEQDDRDRAYSFMSSDSGVDTTPHGRVVREKPLKSTTTYEKYPPSGFASESTKSISFSSPDKLKMSTHDDTRSSGGGDGTIHIPSADAKEPTPESPGSRSNYGEFYCPTTDSLKTYSYTIHMKKSEEEIHDFDMGSWDEYSRDTSGENNYHHTSSFDDDLLLEIDSSRGAAVARLDRTQDDLNKFRQRIDNNVEQQREYSEMMAALQNKVHEYRKHIAELEGRMVGARNRMLDDPTSNVMIFDNYDPGNTYITNHNVELWSPARGKRETILGGGGAPGLTTVNVHAGAGYSGSGVAGYGGGVQAMVGDPNANYEMIARLDEERRRSDEYRMQWENERQKSLSLEDENDRLRREFERYANDSKDKEKTFINRERNLAQYLSDEQRKMLDLWTELQRVRKQFSDLKTHTEEDLDKQKAEFTRAIRNVNNISRNAAFSAGAGDGLGLYGLEDGGDVNRTTNNYEKVFIETIKRMNGTGGAGSASSADLLEELRKIRGGGSSEGDAELHKELMTKYEESIERNIELESRGDDSQRKIAELEAELRRNREKLNEAQGALKKLHEMAQDSEKNVDGTVSIKRTRSLSPGKTPLPPSEALRAVRNTFRNKDNDIQQLERKLKIAESQVKEFLNKFENADEARRRLDKQFADAKREISNLQKSVDEAERNSRRTDDKLRASEAERVAAEKARKFLEDELAKLQASFQKSSTDDARKLRDEMDEHTNSIQEEFKTRIDELNRRVENLLRENNRLKSEVNPLKDKYRDLENEYNSTQRRIEEKETQIRYSDDIRRNIQKDLDDLREKYDRVHTDNEKILGELEHAQKAAHLAEQQLKEIKIQRDDYQKQKDEHARHLFDIRHKLETEIKGRQDLEKNGARNNDELDKLRQTISDYESQINLLRRHNDELDTTIKGHQGKITHLENELHSRSGEIEKLNDLNQRLQKEKQDILNQKLKLDGDVQALKETIRKLENELEKLRNENKELVGKEARARDAANQQLSRANLLNKELEDTKQDLKHSTDVNKQLEQDIRDLKERLANIGKGGRISRDSTTGTDGGAFGDRSSVADPSRTRGAAGSTVFVPAAEDIESRGGGEIDIPSSGDVIHGRDGRDGRDAGNRGTHTITNTKERIERIEKNILDRYHDDELVEHKIREVNDRWKRELERLENEKDDLERRIRELEDELSQIGRGNDKTENDITELKRKHAAEIDKLKSDISALHDKHLSDLDDEKEQYGKAVENLKSVEDDLRDKLNNLEKQLADSLNRENELEREKRDYDEKINSLYGQNQKIKDEWDDFRNDADKEIQKWKTDAYTVRSEAKALETTNTALKAQLQAANDRIDHLTKTVNDHTSKVRDLTSQVRHLEDELADTKGNLVQKEMDLESTQNRLRSLEDQHSTLQSDANKWRGELDAALRENDILKSNNTNMETDLTRLKNRLKSAEDALKELKNSLSHAKTEKERLQNAFREKTKQADHLNQLASQFDTKLTKLRNELQDTNDKLITSDTERNALRNELQKLSQELKFGNEQIQRKSDEYQTTIDDLAHSHRVSEDSRLNALQELEARKYEINDLTSRLDSTEQRLATLQQDYIKADSERDILSDALRRFQSSANRVINFHTFVDGGAGYVDGVPGGTSVIGGGPSAQRSGAYDPSSGGVIGSGISGGPGGSDFGREIEIGRGDSDQSDVAYPRSVPFPPSADFSSGRPGAASAGGRVINNLDGTTTVNMNGGFDIANLEGTLQSLLNKIEKLEMERNELRDTLARMKKKTTETHTTINQKETRYRNIEDNLQDAEEERRALESRLQSAKTLLRSQEEALKQRDEERRQMKSKMVAAELQARGKEAQLRHLNEQLKNLRTDLDNAHTDIRSLRDKEEQWDSSRFQLETKMRESDSDTNKYQLQIASFESERQILTEKIKELDGALRLSDSKVQDMKDDTDKLRRDLTKAESVENELRKTIDIQSKTSHEYQLLKDQLLNTQNELNGANNRKQQLENELLNVRSEVRDYKQRVHDVNNRVSELQRQLQDANTEKNRVEDRFLSVEKVVNTMRTTETDLRQQLETAKNEKRVATKELEDLKRRLAQLENERRNSSQLSDGWKKEKITLLKKIELLENEKRRTDAAIRETALQREAIEKSLNAMERENKELYKNCAQLQQQIAQLEMENGNRILELTNKQREEQERQLIRMRQEKGQIEKVIENRERTHRNRIKQLEDQIAILRDQLDGERRRRREYVDRSMVNDIGRLGSNVLGIRNSYGDNSIDAIINGGSRSVGFYPRSTFASNPLTPPLGSSTPTHRPHVTDFRSAVDAGSSYRRPISTIEDSGSVYGGSIRDRDSVYGGGGRDSSFGTRAGDSISRAGVEPRDPSLVEIPSNEPPMTTSTHSQGGSRYDTLAPNRDDL
Protein: Chaperone protein DnaJ 2 (P9WNV7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity). Inhibits the beta-lactamase and RNase activity of RNase J.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01152}.
Interaction partners:
- Chaperone protein DnaK
- Heat-inducible transcription repressor HrcA
- Chaperone protein HtpG
- Protein GrpE
- Ribosomal RNA small subunit methyltransferase E
- Conserved hypothetical proline rich protein
- Chaperonin GroEL 1
- Chaperonin GroEL 2
- Hypothetical alanine and valine rich protein
- Conserved hypothetical proline and threonine rich protein
Sequence:
MARDYYGLLGVSKNASDADIKRAYRKLARELHPDVNPDEAAQAKFKEISVAYEVLSDPDKRRIVDLGGDPLESAAAGGNGFGGFGGLGDVFEAFFGGGFGGGAASRGPIGRVRPGSDSLLRMRLDLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSVPIPCDTCGGRGEVQTVQRSLLGQMLTSRPCPTCRGVGVVIPDPCQQCMGDGRIRARREISVKIPAGVGDGMRVRLAAQGEVGPGGGPAGDLYVEVHEQAHDVFVREGDHLHCTVSVPMVDAALGVTVTVDAILDGLSEITIPPGTQPGSVITLRGRGMPHLRSNTRGDLHVHVEVVVPTRLDHQDIELLRELKGRRDREVAEVRSTHAAAGGLFSRLRETFTGR
Protein: Probetacellulin [Cleaved into: Betacellulin (BTC)] (Q05928)
Organism: Mus musculus (Mouse)
Function: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Subcellular location: [Betacellulin]: Secreted, extracellular space.; SUBCELLULAR LOCATION: [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Receptor tyrosine-protein kinase erbB-4
- Epidermal growth factor receptor
- Receptor tyrosine-protein kinase erbB-3
- Pro-epidermal growth factor
- Epigen
- Amphiregulin
- Pro-neuregulin-1, membrane-bound isoform
- Receptor tyrosine-protein kinase erbB-2
- Proepiregulin
- Proheparin-binding EGF-like growth factor
Sequence:
MDPTAPGSSVSSLPLLLVLALGLAILHCVVADGNTTRTPETNGSLCGAPGENCTGTTPRQKVKTHFSRCPKQYKHYCIHGRCRFVVDEQTPSCICEKGYFGARCERVDLFYLQQDRGQILVVCLIVVMVVFIILVIGVCTCCHPLRKHRKKKKEEKMETLDKDKTPISEDIQETNIA
Protein: Monoterpene synthase 7, chloroplastic (HcTPS7) (Alpha-pinene synthase) (EC 4.2.3.-) (Alpha-terpinene synthase) (EC 4.2.3.115) (Beta-phellandrene synthase) (EC 4.2.3.-) (Beta-pinene synthase) (EC 4.2.3.-) (Gamma-terpinene synthase) (EC 4.2.3.114) (Myrcene synthase) (EC 4.2.3.15) (Sabinene synthase) (EC 4.2.3.-) (Terpinolene synthase) (EC 4.2.3.113) (W6HUT3)
Organism: Hedychium coronarium (White butterfly ginger-lily)
Function: Monoterpene synthase involved in the biosynthesis of volatile compounds present in floral scent. Mediates the conversion of (2E)-geranyl diphosphate (GPP) into sabinene and sub-products such as alpha-thujene, alpha-pinene, beta-pinene, myrcene, alpha-phellandrene, alpha-terpinene, beta-phellandrene, gamma-terpinene and terpinolene. Unable to use farnesyl diphosphate (FPP) as substrate.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:25056927}.
Interaction partners:
Sequence:
MSVSLSFAASATFGFRGGLGGFSRPAAAIKQWRCLPRIQCHSAEQSQSPLRRSGNYQPSIWTHDRIQSLTLSHTADEDDHGERIKLLKCQTNKLMEEKKGEVGEQLQLIDHLQQLGVAYHFKDEIKDTLRGFYASFEDISLQFKDNLHASALLFRLLRENGFSVSEDIFKKFKDDQKGQFEDRLQSQAEGLLSLYEASYLEKDGEELLHEAREFTTKHLKNLLEEEGSLKPGLIREQVAYALELPLNRRFQRLHTKWFIGAWQRDPTMDPALLLLAKLDFNALQNMYKRELNEVSRWWTDLGLPQKLPFFRDRLTENYLWAVVFAFEPDSWAFREMDTKTNCFITMIDDVYDVYGTLDELELFTDIMERWDVNAIDKLPEYMKICFLAVFNTVNDAGYEVMRDKGVNIIPYLKRAWAELCKMYMREARWYHTGYTPTLDEYLDGAWISISGALILSTAYCMGKDLTKEDLDKFSTYPSIVQPSCMLLRLHDDFGTSTEELARGDVQKAVQCCMHERKVPEAVAREHIKQVMEAKWRVLNGNRVAASSFEEYFQNVAINLPRAAQFFYGKGDGYANADGETQKQVMSLLIEPVQ
Protein: Homeobox protein Hox-D12 (Homeobox protein Hox-4H) (P35452)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Sonic hedgehog protein
Sequence:
MCERSLYRAGYVGSLLNLQSPDSFYFSNLRPNGGQLAALPPISYPRGALPWAATPASCAPAQPAGATAFGGFSQPYLAGSGPLGLQPPTAKDGPEEQAKFYAPEAAAGPEERGRTRPSFAPESSLAPAVAALKAAKYDYAGVGRATPGSTTLLQGAPCAPGFKDDTKGPLNLNMTVQAAGVASCLRPSLPDGLPWGAAPGRARKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRVVLREQALALY
Protein: Floral homeotic protein AGAMOUS (pMADS3) (Q40885)
Organism: Petunia hybrida (Petunia)
Function: Probable transcription factor involved in regulating genes that determines stamen and carpel development in wild-type flowers.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
Interaction partners:
Sequence:
MEFQSDLTREISPQRKLGRGKIEIKRIENTTNRQVTFCKRRNGLLKKAYELSVLCDAEVALIVFSSRGRLYEYANNSVKATIERYKKACSDSSNTGSIAEANAQYYQQEASKLRAQIGNLQNQNRNFLGESLAALNLRDLRNLEQKIEKGISKIRAKKNELLFAEIEYMQKREIDLHNNNQYLRAKIAETERSQQMNLMPGSSSYDLVPPQQSFDARNYLQVNGLQTNNHYPRQDQPPLQLV
Protein: Probable asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (O94567)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Cytosolic asparaginyl-tRNA synthetase which catalyzes the specific attachment of asparagine to its cognate tRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Glutamyl-tRNA
- Putative proline--tRNA ligase C19C7.06
- Isoleucine--tRNA ligase, cytoplasmic
- Glutamyl-tRNA
- DNA repair protein rad16
- Isoleucine--tRNA ligase, mitochondrial
- Probable proline--tRNA ligase, mitochondrial
- Crossover junction endonuclease mus81
- Probable glutamine--tRNA ligase
- Serine--tRNA ligase, cytoplasmic
Sequence:
MAGLESKVSDMKIKSDVVFYIDEASGNDETGNGSQTSPFKTAIHALETDANCTIFVKKNGSEEFEPITTNALKKAKKGVEQAAKKKAKAAEAEAAAAARAAAAKEAEAKRLEAAKNIVLKEPKDAPAAKKIAIIDSTNFRDSRVRVNGWVHRMRTQKGIIFIILRDGTGFLQCVLSGKVYDRASYDFINLGPESTVCLYGVIKELPEGKSAPGNHELVVDYYQILHAAPTGEEAFTNRLNAEAEPSYLLDQRHLVIRGETASSVLKVRARALRAMRDTFENLKMTEVTPPCMVQTQVEGGATLFKFNYYGQDAYLTQSSQLYLEAALPALGSVYTIQESFRAEKSLTRRHLSEFTHVEFELPFVNFGEFLEIIEEFICQTIDRLLDDPIATPLIKQLNPDFVKPSRPFMRLSYEDAIKYLNEHNILTPEGEQHKFGDDIAEAAERKMTDQINRPIFLTYFPLEIKSFYMKRVVDRPELTESVDCLMPNVGEIVGGSMRISDIQELLAAYKREGIDPAPYYWFTEQRKYGTTEHGGCGLGLERFLAWLCDRYTVRECCLFPRFTERCTP
Protein: CD27 molecule (A0A8I5Y9T6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAWPPLYWLCMLGTLVGLLATPAPNNCPDRHYWIGAGLCCQMCGPEKPSWPPQRQLPDSTVYSRLPSQRPLCSSDCIRIFVTFSSMLLVFVLGGILFFHQRRNHGPNEDSQAVPEELCPYSCPREEEGSVIPIQEDYRKPEPASYP
Protein: Expansin-like A1 (At-EXPL1) (AtEXLA1) (AtEXPL1) (Ath-ExpBeta-2.1) (Q9LZT4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Probable xyloglucan endotransglucosylase/hydrolase protein 23
- mRNA-decapping enzyme subunit 2
- At1g07135
Sequence:
MGSFLFLIVVIFLFSSSVNACDRCLHRSKAAYFSSASALSSGACAYGSMATSFFAGHIAAAIPSIYKDGAGCGACFQVRCKNPKLCSTKGTIVMITDLNKSNQTDLVLSSRAFRAMAKPIVGADKDLLKQGIVDIEYQRVPCDYGNKNMNVRVEEASKKPNYLEIKLLYQGGQTEVVSIDIAQVGSSPNWGYMTRSHGAVWVTDKVPTGAIQFRFVVTGGYDGKMIWSQSVLPSNWEAGKIYDAGVQITDIAQEGCDPCDAHIWN
Protein: Serine protease svh-1 (EC 3.4.21.-) (HGF/MSP/plasminogen-like protein svh-1) (Suppressor of vhp-1 deletion lethality protein svh-1) (Q17800)
Organism: Caenorhabditis elegans
Function: Serine protease which ensures proper pharyngeal pumping during larval growth by regulating the levels of extracellular matrix component fbl-1. Independently of its enzymatic activity and probably by acting as a ligand for tyrosine-protein kinase receptor svh-2, involved in axon regeneration after injury by promoting the generation of productive and stable growth cones. May play a role in gonad development.
Subcellular location: Secreted {ECO:0000305|PubMed:22388962}.
Interaction partners:
- Tyrosine-protein kinase receptor svh-2
- Mitogen-activated protein kinase kinase kinase mlk-1
- Amyloid-beta-like protein
- Tyrosine-protein phosphatase vhp-1
- GLH-binding kinase 1
- Papilin
- Dual specificity mitogen-activated protein kinase kinase mek-1
- Transcription factor ets-4
- Fatty acid amide hydrolase 1
- CCAAT/enhancer-binding protein homolog 1
Sequence:
MYIVIVTMRTILFFGIFFIFIFQCAKCIELKIFEDLLEVRSQSGLFFPLCSKSFHQKYGEQACASISSTFLSYSTVSLQQYTYSVGCTTSVCFTFLSSFCKTGVKVFCSPSLCASGTLQIGSKCLSISTVPVQGYSEANYYCNPATLISSLKPTEIESIRDTILPTFADTRLFLTSGLRQGATWKWGNGDTVEQEVTGTGRCLALQAGNLVAIDCDSEAYVFCESGRECIARDKEYSGTANRTSDGKMCLMWNDPTVLFRRERDLEILNHNFCRFVNDADGKKSATPVCYTKPNELSQCYIPPCPESFNDVVPIESGDSCPIGSISCDNGSKCISEKFQCDYEVDCNDGSDEHNCEDYLQYYELIGAYRLADNIIEVWTFIPHVQGCARKCRESLLMCEAFSYEPKSQTCLLTDTSQTFSSLARKITSLYYRRRFSTKDVEFQVENKVLYATKSAKKGHVCDDNYSREKLSSICRVLGFGDPIYTVESHQSESSLGPLQPTTLHPTNPSFDSPSSVSQMRRTSPSATLAPRLPAWNLSCLREPNCTSTVISTCEPIRCSHCQQAACGDGSCIRFDQLCNGQIDCQSGEDEDYCRANSFRLTNGSDTSGYLEVLFRSRWEPICADHLNGKISNSICDAMRLGEHGFILSTNATISSGYNVNCDVDCSIRRSSSCTRHARISCISQNGMSSASQCGLRYVEVNARDAAKSRIARVVGGFETVPGAFPWTAALRNKATKAHHCGASILDKTHLITAAHCFEEDERVSSYEVVVGDWDNNQTDGNEQIFYLQRIHFYPLYKDIFSHDIAILEIPYPGIEFNEYAQPICLPSKDFVYTPGRQCVVSGWGSMGLRYAERLQAALIPIINRFDCVNSSQIYSSMSRSAFCAGYLEGGIDSCQGDSGGPFACRREDGAFVLAGVISWGDGCAQKKQPGIYTMVAPYLSWISAIINGQPV
Protein: Nuclear hormone receptor family member nhr-25 (Q19345)
Organism: Caenorhabditis elegans
Function: Orphan nuclear receptor and probable transcription activator, required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. Regulates vulval precursor cell (VPC) differentiation, in concert with homeobox protein lin-39. Involved in promoting embryogenesis, in concert with homeobox protein nob-1. May play a role in modulation of lifespan and immunity.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:10772806, ECO:0000269|PubMed:15314147}.
Interaction partners:
- Pre-mRNA-splicing factor RBM22
- Homeobox protein mab-5
- Transcription factor elt-1
- Homeobox protein nob-1
- Beta-catenin/armadillo-related protein 1
- Beta-catenin-like protein hmp-2
- T-box transcription factor tbx-8
- Beta-catenin homolog sys-1
- Armadillo repeat-containing protein wrm-1
- Transcription factor elt-3
Sequence:
MTDVERMVLRPNHEGEMCPVCGDRVSGYHYGLLTCESCKGFFKRTVQNKKQYQCSAEANCHVDRTCRKRCPSCRFQKCLTMGMKMEAVRADRMRGGRNKFGSFYKKDRAHRMQRNAMRVSTVQVPAVLGAQSQAQTFYQPPEHQVSSSTTDQNNQINYFDQTKIKTEYIKTEYDAHLQSPTLSSSTNQQLSVSDFIMRPGYLVDPQDSLAVLLGSTIDDPLLRHTFPAAYQLNEVKQEPFDYSEQFIHHSLHDYPTYTSNTTNYATMMPMTTVSSTQSLVTSTSSTTTGRMTEASSTSPILPLCPAPTEKTVDHFYNSSIAEMCKTLPDDAQIARIFTSVKGTSKPEKHAFSIQVAEENLKDIVIWAKNDQLFSKLSLDDQMILLQTSWTTVHIVDITNAMVHGNLLSQYKMSNGDEVPVGLVALLGNQTFVSSWNDVVIRLRNMGFTNFDYCAFRFLALFDQSMDSFPAVSTARSRVLQSWREVRCTTAFLEIFEQIRRLAYDSLRYLWNLHSNCPTNWEQFFPEASLVLEMIRTTVNRSASSSVTAITQVPAIQLPTPQATYTAVPYMAS
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (Q24495)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MDCATRKQQQLRAHHQQQQIQIQTHGRKRQQLQKQRHNHHHYYQNPQQQQKHFVWLVVGILTIFLARHANAADLVINVPNASSNANAFYRIDYSAPFGFPEPNTTIPASDIGKDIKNSRALPGTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTYRSAWLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYSDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRVYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKIASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHLTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEAYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPFHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPLSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMGTLPIRASLAMAEKLDADLMTNKDEDEDQEQQHEQQLQLATEVKPKGSNDDEEDEEDDDDDDDDQQPLNNETTATLSSASCSSSTHDVHVVLQEAIEQPKQEQERICAGTQSHADTESDNTDSDDDDEDGDGKVAKDGAVADEDGWWY
Protein: NAC domain-containing protein 45 (A4VCM0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor directing sieve element enucleation and cytosol degradation. Not required for formation of lytic vacuoles. Regulates, with NAC086, the transcription of NEN1, NEN2, NEN3, NEN4, RTM1, RTM2, UBP16, PLDZETA, ABCB10 and At1g26450.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
Interaction partners:
- UMP kinase
Sequence:
MAPVSLPPGFRFHPTDEELITYYLKRKINGLEIELEVIAEVDLYKCEPWDLPGKSLLPSKDQEWYFFSPRDRKYPNGSRTNRATKGGYWKATGKDRRVSWRDRAIGTKKTLVYYRGRAPHGIRTGWVMHEYRLDETECEPSAYGMQDAYALCRVFKKIVIEAKPRDQHRSYVHAMSNVSGNCSSSFDTCSDLEISSTTHQVQNTFQPRFGNERFNSNAISNEDWSQYYGSSYRPFPTPYKVNTEIECSMLQHNIYLPPLRVENSAFSDSDFFTSMTHNNDHGVFDDFTFAASNSNHNNSVGDQVIHVGNYDEQLITSNRHMNQTGYIKEQKIRSSLDNTDEDPGFHGNNTNDNIDIDDFLSFDIYNEDNVNQIEDNEDVNTNETLDSSGFEVVEEETRFNNQMLISTYQTTKILYHQVVPCHTLKVHVNPISHNVEERTLFIEEDKDSWLQRAEKITKTKLTLFSLMAQQYYKCLAIFF
Protein: Desiccation-related protein clone PCC6-19 (CDET6-19) (P22239)
Organism: Craterostigma plantagineum (Blue gem) (Torenia plantagineum)
Interaction partners:
Sequence:
MAQFGGEKYGGRHTDEYGNPIQQGAGAHRGGGIMGGGQQAGQHGTTGVLGHGTAGQHGTTGGGLGHGTAGTGGALGGQHRRSGSSSSSSSSESDGEGGRRKKGMKDKMKEKLPGGHGTTTDQQQYGTAATHGQAQQHEKKGIMDKIKEKLPGGQH
Protein: Signal recognition particle 14 kDa protein (SRP14) (Q8I613)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU368100}.
Interaction partners:
- Signal recognition particle subunit SRP9
- Signal recognition particle subunit SRP68
- Signal recognition particle subunit SRP72, putative
- Signal recognition particle 54 kDa protein
- Small ribosomal subunit protein eS30
- Signal recognition particle subunit SRP19
- Uncharacterized protein
- Signal recognition particle receptor subunit beta
- Signal recognition particle receptor subunit alpha, putative
- 60S ribosomal protein L14, putative
Sequence:
MVLLSNDVFIQELNKLCGPVEGKKKTSIWITMKRVKRNDIKTLTSNKDAGDKKNTKKVNKNDNKGNKEYMCLIRATDGKNKKISTHVYDNVISFTQNINSIIKC
Protein: Serine acetyltransferase 2 (AtSAT-2) (AtSERAT3;1) (EC 2.3.1.30) (Q8S895)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15579666}.
Interaction partners:
- Phosphoserine phosphatase, chloroplastic
- S-sulfo-L-cysteine synthase
- cysteine synthase
- Serine racemase
- Cysteine synthase, chloroplastic/chromoplastic
- Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic
- Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic
- Cysteine synthase, mitochondrial
- Cysteine synthase 1
- Bifunctional L-3-cyanoalanine synthase/cysteine synthase D1
Sequence:
MNGDELPFESGFEVYAKGTHKSEFDSNLLDPRSDPIWDAIREEAKLEAEKEPILSSFLYAGILAHDCLEQALGFVLANRLQNPTLLATQLLDIFYGVMMHDKGIQSSIRHDLQAFKDRDPACLSYSSAILHLKGYHALQAYRVAHKLWNEGRKLLALALQSRISEVFGIDIHPAARIGEGILLDHGTGVVIGETAVIGNGVSILHGVTLGGTGKETGDRHPKIGEGALLGACVTILGNISIGAGAMVAAGSLVLKDVPSHSVVAGNPAKLIRVMEEQDPSLAMKHDATKEFFRHVADGYKGAQSNGPSLSAGDTEKGHTNSTS
Protein: Calbindin 2 (H3BN14)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSKSDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSAEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKEMNIQQLTNYRKSVMSLAEAGKLYRK