wanglab/gogpt-training-data huggingface dataset:
Protein: Slowpoke 2, isoform F (A0A0B4JD38)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSSSNLEQMPSGSSNDNSDNNNNHNCSRLTSIRNYKLPNWFPHRAEENKRKKRVEQQRQQQRQRRGAKVFKCVSDSTGHLTLAPSRLFERTPMSPSDSLDEIALQIPRVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYGCEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATASENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQDTSNADTSHVSNSPVERWGPFSAFSRHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLADEARDNHAQQIERAEIANLVRSRMESLNLPTIDYDDVSEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQKTFERHNSRRKSNISFCSNINLGATCGPQMPQMNMNMANTAVGAGSRRGSGIAGLNPMQMQSVQTLAGYGSSSQRCSPPMQQIKSNSLSLPDSPTVVGNQRGRSNSLRIDNDILLRRSSSLRQGLPSVGVSHGRRKSSLEEIGISHFTTLMQATNHSNPIKISLNGSIGMENQISLQVTPPEEPTPMLGVPCMLGGGGGGGINPSGAGSSTGGMLGGGSSLAINTADLGPGPSTSSGASGSLQAQDSLGQQSSQVSSPQHLQGTIV
Protein: DNA-binding protein D-ETS-6 (P29776)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus.
Interaction partners:
- FI03911p
- DNA-binding protein D-ETS-3
Sequence:
MAILQNSRQSHKQLPIISQTIRSAWCQQRPINAMHQDVRQKSIGSGNETKLEAKETEVPTNRRRRRRRCSSSSTSDSSASSYSSTDSDSGSSTSSSSIRSQLPALNLPVPLPLATPTPPAVSSPHQAPSPRRNSSDSNRSVSPVEVPVDPHAWTPEDIASWVRWATRKFKLDPEPDIDRFPKDAQELCDLSRADFWVCAGSRRGGMLLAQHFAISLYHATGRETSPMLNDDEPNPYQLLNAASHRLVAQGSGGQIQLWQFLLELLADSSNANAISWEGQSGEFRLIDPDEVARRWGERKAKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGLMAACQAQAQGGDPASSMLGSYNHHAGGAMQLGRHPPPLHHHPQHSHPHHQLGQPHFLHPHHSSPASNSSSLGFPSSSTASSQASPGQAPASSSASTSNFTAPFQGGTAGVDPARTSTSSAGNYDQGPVTPTTNAFN
Protein: Vesicle-associated membrane protein, putative (Q38D47)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046278}; Lipid-anchor {ECO:0000256|ARBA:ARBA00046278}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00046278}.
Interaction partners:
- Syntaxin 5
- SNARE protein, putative
- Golgi SNARE protein-like
- Vesicle transport v-SNARE N-terminal domain-containing protein
- Sec1 family transport protein, putative
- Vacuolar assembly protein vps41, putative
- Vacuolar protein sorting 33, putative
- Vacuolar protein sorting complex subunit, putative
- Golgi vesicular membrane trafficking protein, putative
- Longin domain-containing protein
Sequence:
MKLYSLAIVKPYPSGVEKQPVICSQAIDVSSFGFFQRNSAREFIVFLTRTVSNRVAKGVKTQITENGNVVFAHATFDGLVALAISDVEYNSRVAFTLLGDLVQQFQTTFRGKYDLVDGKEDNFLSWPHLTETLEKYQKPEEQDKILKIKRDIEDTKVIMYNAIDQIIERGQKIDDLVAQSEDLGMASKTFYKQAKKTNSGCCTVM
Protein: Sulfhydryl oxidase 1 (hQSOX) (EC 1.8.3.2) (Quiescin Q6) (O00391)
Organism: Homo sapiens (Human)
Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
Subcellular location: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:23704371}; Single-pass membrane protein {ECO:0000305|PubMed:17331072}. Secreted {ECO:0000269|PubMed:29757379}. Note=A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor. {ECO:0000305|PubMed:29757379}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10708601}. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells. {ECO:0000269|PubMed:10708601}.
Interaction partners:
- FAD-linked sulfhydryl oxidase ALR
- Thioredoxin
Sequence:
MRRCNSGSGPPPSLLLLLLWLLAVPGANAAPRSALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVAVRRVLNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSFYTAYLQRLSGLTREAAQTTVAPTTANKIAPTVWKLADRSKIYMADLESALHYILRIEVGRFPVLEGQRLVALKKFVAVLAKYFPGRPLVQNFLHSVNEWLKRQKRNKIPYSFFKTALDDRKEGAVLAKKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAKAKEVLPAIRGYVHYFFGCRDCASHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSEDPQFPKVQWPPRELCSACHNERLDVPVWDVEATLNFLKAHFSPSNIILDFPAAGSAARRDVQNVAAAPELAMGALELESRNSTLDPGKPEMMKSPTNTTPHVPAEGPEASRPPKLHPGLRAAPGQEPPEHMAELQRNEQEQPLGQWHLSKRDTGAALLAESRAEKNRLWGPLEVRRVGRSSKQLVDIPEGQLEARAGRGRGQWLQVLGGGFSYLDISLCVGLYSLSFMGLLAMYTYFQAKIRALKGHAGHPAA
Protein: Pre-neck appendage protein (Gene product 12) (gp12) (NP1) (Protein p12) [Cleaved into: gp12*] (P20345)
Organism: Bacillus phage phi29 (Bacteriophage phi-29)
Function: Structural component of the 12 appendages that hang from the lower collar. Adhesion protein that binds to the host cell surface during virus attachment and mediates teichoic acids degradation.
Subcellular location: Virion {ECO:0000269|PubMed:11562162, ECO:0000269|PubMed:19450535}. Note=Present in 36 copies in the virion. {ECO:0000305|PubMed:19450535}.
Interaction partners:
Sequence:
MSTKPELKRFEQFGEMMVQLYERYLPTAFDESLTLLEKMNKIIHYLNEIGKVTNELIEEWNKVMEWILNDGLEDLVKETLERWYEEGKFADLVIQVIDELKQFGVSVKTYGAKGDGVTDDIRAFEKAIESGFPVYVPYGTFMVSRGIKLPSNTVLTGAGKRNAVIKFMDSVGRGESLMYNQNVTTGNENIFLSSFTLDGNNKRLGQGISGIGGSRESNLSIRACHNVYIRDIEAVDCTLHGIDITCGGLDYPYLGDGTTAPNPSENIWIENCEATGFGDDGITTHHSQYINILNCYSHDPRLTANCNGFEIDDGSRHVVLSNNRSKGCYGGIEIKAHGDAPAAYNISINGHMSVEDVRSYNFRHIGHHAATDPQSVSAKNIVASNLVSIRPNNKRGFQDNATPRVLAVSAYYGVVINGLTGYTDDPNLLTETVVSVQFRARNCSLNGVGLTGFSNSDNGIYVIGGSRGGDAVNISNVTLNNSGRYGVSIGSGIENVSITNISGIGDGINSPVALVSTINSNPEISGLSSIGYPTAARVAGTDYNDGLTLFNGAFRASTTSSGKIHSEGFIMGSTSGCEASVSKSGVLTSSSSKTSSERSLIAGSSTSEAKGTYNTILGSLGAVADEQFAALISASQSRASGNHNLILSSYGINTTGSYKVNGGFEKINWELDSLNGRIKARDTVTGGNTWSDFAEYFESLDGQVIETGYLVTLEKGKIRKAEKGEKIIGVISETAGFVLGESSFEWQGAVLKNEFGGIIYEEVTTEDGVKFKRPLPSPDFDPNKNYIPRSQRREWHVVGLLGQIAVRIDETVKQGHGIDAVGGVATDGDNFIVQEITTPYTKEKGYGVAIVLVK
Protein: ADP-ribosylation factor-like protein 2 (O08697)
Organism: Rattus norvegicus (Rat)
Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle (By similarity).
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:11809823}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11809823}. Nucleus {ECO:0000269|PubMed:11809823}. Cytoplasm {ECO:0000269|PubMed:11809823}. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). {ECO:0000250}.
Interaction partners:
- ADP-ribosylation factor-like protein 2-binding protein
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
- Protein unc-119 homolog A
- Tubulin-specific chaperone D
Sequence:
MGLLTILKKMKQKERDVRLLMLGLDNAGKTTILKKFNGEDVDTISPTLGFNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDLPGALSCNAIQEALELDSIRSHHWRIQGCSAVTGEDLLPGIDWLLDDISSRVFTAD
Protein: Probable prefoldin subunit 5 (Q9VCZ8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
Interaction partners:
- Probable prefoldin subunit 6
- Probable prefoldin subunit 4
- GEO07746p1
- Prefoldin subunit 3
- Probable prefoldin subunit 2
- Prefoldin subunit 3
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit theta
Sequence:
MAATPSAPAKSEMIDLTKLSPEQLIQIKQEFEQEITNVQDSLSTLHGCQAKYAGSKEALGTFQPNWENRQILVPLTSSMYVPGRVKDLNRFVIDIGTGYYIEKDLEGSKDYFKRRVEYVQEQIEKIEKIHLQKTRFYNSVMSVLEMKQAAAAKLQSQQQSQPAVTQSS
Protein: Gamma-glutamylcyclotransferase 2-3 (AtGGCT2;3) (EC 4.3.2.7) (Gamma-glutamyl cyclotransferase 2;3) (Q84QC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and plays a significant role in glutathione (GSH) homeostasis. Converts GSH to 5-oxoproline and cysteine-glycine (Cys-Gly) dipeptide in vitro. Possesses low activity towards gamma-glutamyl-L-alanine. Has no activity towards gamma-glutamyl-L-cysteine.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8GY54}.
Interaction partners:
- Leucine aminopeptidase 1
- 5-oxoprolinase 1
- Leucine aminopeptidase 3, chloroplastic
- Glutathione hydrolase 2
- Glutathione hydrolase 1
- Putative inactive glutathione hydrolase 4
- Glutathione hydrolase 3
- Glutathione synthetase, chloroplastic
- Gamma-glutamylcyclotransferase 2-2
- Gamma-glutamylcyclotransferase 2-1
Sequence:
MAMWVFGYGSLIWKTGFPFDESLPGFIKGYRRVFHQGSTDHRGTPDFPGRTVTLEAAHEEVCCGVAYKITKEEDKRDALLHLEVREKQYDQKEYLDFFTDSNASEPAVAGVMVYIASPDKKSNNNYLGPAPLEDIAKQIVKAKGPSGPNRDYLFNLEEALAQLGFKDKHVTDLANQVRHILSESEELDIDATAATANNV
Protein: 3-demethoxyubiquinol 3-hydroxylase (DMQ hydroxylase) (EC 1.14.99.60) (2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase) (Q9I5R6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01658, ECO:0000305|PubMed:11435415}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01658, ECO:0000305|PubMed:11435415}.
Interaction partners:
- Ubiquinone biosynthesis O-methyltransferase
- Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
- UbiH protein
- Ubiquinone biosynthesis accessory factor UbiT
Sequence:
MSADRHYSPIDRFLLQADSALRTLLPFSGQPARPSPAIVEPDGELSEEDTRHIAGLMRINHTGEVCAQALYQGQSLTAKLPEVREAMEEAAEEEIDHLAWCEQRIRQLGSRPSVLNPIFYGLSFGVGAAAGLVSDRVSLGFVAATEDQVCKHLDEHLAQIPQEDRKSRAILEQMRIDEEQHSSNALAAGGLRFPAPVKLGMSLLAKVMTKSTYRI
Protein: Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7) (Q5PT50)
Organism: Rattus norvegicus (Rat)
Function: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).
Subcellular location: Cell membrane {ECO:0000269|PubMed:17628207}; Multi-pass membrane protein {ECO:0000305|PubMed:17628207}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17628207}; Multi-pass membrane protein {ECO:0000305|PubMed:17628207}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q0GE19}.
Interaction partners:
- Solute carrier family 10, member 3
- Sodium/bile acid cotransporter 5
- Sodium-dependent organic anion transporter
- Sodium/bile acid cotransporter 4
Sequence:
MRLLERVRKEWFMVGIVVAIGAAKLEPSVGVNGGPLKPEITVSYIAVATIFFNSGLSLKTEELTSALVHLKLHLFIQVFTLAFFPTTIWLFLQLLSVTSINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVVTPVLLLLFLGSSSSVPFTSIFSQLFMTVVVPLVIGQIVRRYIKDWLERKKPPFGVVSSSVLLMIIYTTFCDTFSNPNIDLDKFSLILILFIIVSIQLSFMLLTFVFSTRNNSGFTPADTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLISLPLLIYHPAQILLGSVLVPTIKSWMVSRQKGVKLTRPTV
Protein: Serine/arginine-rich splicing factor 10 (FUS-interacting serine-arginine-rich protein 1) (Neural-salient serine/arginine-rich protein) (Neural-specific SR protein) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) (Q9R0U0)
Organism: Mus musculus (Mouse)
Function: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May be involved in regulation of alternative splicing in neurons.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:10583508}.
Interaction partners:
- Serine/arginine-rich splicing factor 1
- YTH domain-containing protein 1
- Serine/arginine-rich splicing factor 4
- Transformer-2 protein homolog beta
- RNA-binding protein FUS
- Serine and arginine-rich splicing factor 11
- Serine/arginine-rich splicing factor 3
- Serine/arginine-rich splicing factor 9
- BUB3-interacting and GLEBS motif-containing protein ZNF207
- Heterogeneous nuclear ribonucleoprotein A1
Sequence:
MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYKSGSRYEKESRKKEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH
Protein: NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) (B7ZWM4)
Organism: Mus musculus (Mouse)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}.
Interaction partners:
Sequence:
MLPTSPKTLVLLGALLTGPLGPAGGQDAPSLPWEVQRYDGWFNNLKYHQRGAAGSRLRRLIPANYADGVYQALEEPLLPNPRRLSDAVAKGKAGLPSVHNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDRNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQSSLLMWMAPDPSTGRGGPQGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIALYQWLPSFLQKTPPEYSGYRPFMDPSISPEFVVASEQFLSTMVPPGVYMRNSSCHFRKFPKEGSDSSPALRVCNSYWIRESPNLKTAQDVDQLLLGMASQISELEDRIVIEDLRDYWPGPERFSRTDYVASSIQRGRDMGLPSYSQALLALGLEPPKNWSALNPQVEPQVLEATAALYNQDLSQLELLLGGLLESHGVPGPLFSNIILDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTTLRDVLVAVSNVDPSALQPNVFFWQEGAPCPQPRQLTTDGLPQCAPVTVIDYFEGSGAGYGVTLVAVCCFPLVSLIVAGVVAHFRNRERKMLLKKGKESLKKQPASDGVPAMEWPGPKEKSYPVTLQLLPDRSLQVLDKRFTVLRTIQLQSPQQVNLILSSNSGRRTLLLKIPKEYDLVLMFNSEEDRGAFVRLLQDLCICCTPGLHIAEVDEKELLRKAVTKQQRAGILEIFFRQLFAQVLDINQADAGTLPLDSSQQVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYISFREFLDILVVFMKGSSEDKSRLMFTMYDLDGNGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGGAGGTKDIFKQSSACRVSFINRTPGNSSCPPETALSDMETPELGSTGLKKRFGKKVMGPSPRLYTEALQEKKQSGFLAQKFKQYKRFVENYRRHIVCVTIFSAICIGLFADRAYYYGFASPPTDIEETTYVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRWIAMAAVVLAVLHSAGHAVNVYIFSVSPLSLMACVFPNVFVNDGSKFPPKYYWWFFETVPGMTGVLLLLVLAIMYVFASHHFRRHSFRGFWLTHHLYVVLYVLIIIHGSYALIQLPSFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPKTFEYKSGQWVRIACLDLGTNEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSPPVGGTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSMGSQMLCKKIYFIWVTRTQRQFEWLADIIREVEENDRQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKALNRSLFTGLRSITHFGRPPFELFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRAHFVHHYENF
Protein: Iron-sulfur cluster assembly SufBD family protein Rv1461 [Cleaved into: Endonuclease PI-MtuHIIP (EC 3.1.-.-) (Mtu pps1 intein)] (P9WFP7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable conserved ATP-binding protein ABC transporter
- Probable cysteine desulfurase
- Possible nitrogen fixation related protein
- Iron-sulfur cluster assembly SufBD family protein Rv1462
- Conserved protein
- Uncharacterized protein Rv3778c
- Probable transcriptional regulatory protein
- Probable hercynylcysteine sulfoxide lyase
Sequence:
MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGANAQRGLSEAVVRDISAKKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYFVRSTEKQAASWDDLPEDIRNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGVIFLDTDTGLREHPDIFKEYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVGDFVTGHDGRPHRVTAVQVRDLDGELFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRKERNGWKAEVNSTKLRSAEPRWIAAKDVAEGDFLIYPKPKPIPHRTVLPLEFARLAGYYLAEGHACLTNGCESLIFSFHSDEFEYVEDVRQACKSLYEKSGSVLIEEHKHSARVTVYTKAGYAAMRDNVGIGSSNKKLSDLLMRQDETFLRELVDAYVNGDGNVTRRNGAVWKRVHTTSRLWAFQLQSILARLGHYATVELRRPGGPGVIMGRNVVRKDIYQVQWTEGGRGPKQARDCGDYFAVPIKKRAVREAHEPVYNLDVENPDSYLAYGFAVHNCTAPIYKSDSLHSAVVEIIVKPHARVRYTTIQNWSNNVYNLVTKRARAEAGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEVLSVAFAGEDQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRTSYRGLVQVNKGAHGSRSSVKCDALLVDTVSRSDTYPYVDIREDDVTMGHEATVSKVSENQLFYLMSRGLTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQMEGAVG
Protein: Spindle pole body protein pcp1 (Q92351)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Spindle pole body component that binds calmodulin. Overexpression of pcp1 causes the formation of supernumerary SPB-like structures and disrupts both mitotic spindle assembly and chromosome segregation.
Subcellular location: Nucleus {ECO:0000269|PubMed:11864908}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:11864908, ECO:0000269|PubMed:15546621, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Serine/threonine-protein kinase plo1
- Tubulin alpha-2 chain
- Septation initiation protein sid4
- Microtubule protein alp7
- Nuclear envelope protein ndc1
- Spindle pole body component alp4
- Gamma tubulin complex adapter mto2
- Spindle pole body protein ppc89
- Kinesin-like protein cut7
- Spindle pole body-associated protein sad1
Sequence:
MSERDFNTQSPKFKDENANSVISQSDFLGKSLKNNNDDYSDFRGSYLNDKSSFQTPLRNGSYQPKGSLEFTPLLQSSNKNSDKYNGSLGDKGSFDPNSYGLSAISKQATQEALSISQGNDSYDVSKLTDLSKNSEIDHTDGELPANAALTLREQEKVLEKVSRENFGLRIKIVCLEKRLESMAPEQIKEAVKDNVELHAERANLQLQLKRTESLLQKSEDKNFKLEEKVDYLSKVNDVEQSQNVKVFTERIRFLENALEKVQREKDSLSTEMEEDKSNKEVDYEYEIRQLQNRLDELSEELDVAQDLLTEKEDEIATLKRQIEEKENSSSAFENEENSSYVHLQEDYAILQAKCDEFADRIQVLTADLEKEKENQIMHESEASIGLTDSMQVHTLQEQLHKANEEIEFLHDQISRMNEEGKNFEDIMLQFRSLEEERDVLESKLQTLEDDNNSLRLMTSSLGNQIESLRTQNREIDEEKNHLRLLASKNSDKALAETNIRLQEVTKELETLRMKNSNDLNEIHDLREENEGLTLKIDSITKEKDRLINELEQRIKSYEVNVSELNGTIDEYRNKLKDKEETYNEVMNAFQYKDNDLRRFHESINKLQDREKELTSNLEKKNLVISSLRETVAMLEKERESIKKYLSGNAKDLDNTNLMEILNDKISVLQRQLTDVKDELDVSEEEREEAIVAGQKLSASFELMSNEKQALELKYSSLKNELINAQNLLDRREEELSELSKKLFEERKIRSGSNDDIEKNKEINVLNSELADKLAQIRHLESDKMELDKLVHHLNRGIEEANIEENAVKKRLCLLMGCDYSSVSILQIVSQIEHFVNQQIQTIRSLKQELRHDFVQFSGKKEQELSRSFEKFGLGTETKHDILAQRNRNVSEKMNDLENAAQKFFSSPDRKNGYLYPSEHTSKIEYLEKTIEDLKLALQDELKNRNLLMDDISSYNKQTTKLQEKIKWLERERSILIDELESYRSNQFNYQNNLVQDKNELEERLKEIQKELEVYNNHFMKQAELMTSNVTDESQLMLKTLREALQSKTNNIDHLSTILERNRKEYKSLLDDYNQLRARYKNLQSNTPQSTQSGQYESEIKGLSKLTKYLQSKCRREHSLRLDLAFSKKFILMQLTGYETCNKINLRMLQKIGISPDPDLSKKHIKLKSLIIVVCSIERMKRMKNEWLKQAQLKQSLQRAAAKAKTANY
Protein: Transcription factor GATA-4 (DNA-binding protein GATA-GT2) (GATA-binding factor 4) (P46152)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P43694}.
Interaction partners:
- Homeobox protein Nkx-2.5
- Zinc finger protein ZFPM2
- Nuclear factor of activated T-cells, cytoplasmic 4
- T-box transcription factor TBX5
- Serum response factor
- Heart- and neural crest derivatives-expressed protein 2
- Myocyte-specific enhancer factor 2C
- Nuclear factor of activated T-cells 5
- Nuclear factor of activated T-cells, cytoplasmic 3
- Nuclear factor of activated T-cells 1
Sequence:
MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSGAASGATSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYSSSGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPARHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPPGESLPPSSGASSNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGSSIHPVLSALKLSPQGYPSPVTQTSQASSKQDSWNSLVLADSHGDIITA
Protein: Potassium channel subfamily K member 17 (2P domain potassium channel Talk-2) (Acid-sensitive potassium channel protein TASK-4) (TWIK-related acid-sensitive K(+) channel 4) (TWIK-related alkaline pH-activated K(+) channel 2) (TALK-2) (Q96T54)
Organism: Homo sapiens (Human)
Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24972929}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Potassium channel subfamily K member 18
- Potassium channel subfamily K member 16 channel 1)
- Keratin, type II cytoskeletal 2 oral
Sequence:
MYRPRARAAPEGRVRGCAVPSTVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVNHWASRLGGTWQDPDKARWLAGSGALLSGLLLFLLLPPLLFSHMEGWSYTEGFYFAFITLSTVGFGDYVIGMNPSQRYPLWYKNMVSLWILFGMAWLALIIKLILSQLETPGRVCSCCHHSSKEDFKSQSWRQGPDREPESHSPQQGCYPEGPMGIIQHLEPSAHAAGCGKDS