wanglab/gogpt-training-data huggingface dataset:
Protein: Ent-copalyl diphosphate synthase 1 (IeCPS1) (EC 5.5.1.13) (G3E4M6)
Organism: Isodon eriocalyx (Plectranthus eriocalyx)
Function: Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities, and in the production of gibberellins phytohormones. Catalyzes the conversion of (2E,6E,10E)-geranylgeranyl diphosphate (GGPP) to ent-copalyl diphosphate (ent-CPP).
Interaction partners:
Sequence:
MLQSMGDGEISISPYDTAWVALVEDDGGGRRQPQFPSSLEWISSNQLADGSWGDAGTFSIFDRILNTLACVVALRSWNIHPHKTDKGIWFMKKNMCRIDEENLEHMPIGFEVALPSLIDIAKKLEIDIPTQTRGLQEIYARREIKLKKIPRDIMHQVPTTLLHSLEGMAGLKWEKLLKLQSQDGSFLFSPSSTAFALQQTRDHGCLKYLTNHIHKFNGGVPNVYPVDLFEHLWAVDRLQRLGLSRYFQPEIEECIAYVHRQWTEKGICWARNSQVEDIDDTAMGFRLLRLHGYEVSADVFRHFKSDGGEFFCFKGQSTQAVTGMYNLYRASQLMFPGENILVDAARFSANFLQLKRANNDLLDKWIITKDLPGEVGYALDVPWYASLPRVETRFYLDQYGGDDDVWIGKTLYRMPYVNNNKYLELAKLDYNNCQALHQQEWQNIQKWYRSCSLGEFGMTERSLLQTYYVAAASVFEPEKSQERLAWAKTAILMETISSHFEFQQLSRDQKRAFITEFEHDSILKYTNGGRYKRRSSLVGTLVRTLNHLSLDILLAHGRDIHQPLKNAWCKWLNSWEEGGDAELLLRTLNLMSGGGRRRRWASEELLSSNPKHEQLLKATIGVCDKLRLFQRRKVQGGNGCMNATGITTVEIESEMRELVKLVVTRSSSEDLDSEIKQNFLTIARSFYYAAYCNQGTINFHIAKVLFEKVL
Protein: Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Q96K76)
Organism: Homo sapiens (Human)
Function: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21362556}.
Interaction partners:
- DNA polymerase beta
- F-box/WD repeat-containing protein 1A
- F-box/WD repeat-containing protein 11
- Ubiquitin carboxyl-terminal hydrolase 50
Sequence:
MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTPVRKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLEDSSAGEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTFIDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSLIYELFSVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQVFQSYKPGEVMVKVHVVDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYNDLRLLSVSSKTLKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRTAYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIESPLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADNAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKAEPYAADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVYQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLSEISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD
Protein: T12C22.21 protein (Transmembrane protein) (Q9LPD7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At2g32380
- Ubiquitin-conjugating enzyme E2 36
- HR-like lesion-inducing protein-like protein
- At1g04340/F19P19_23
- AT5g43460/MWF20_18
- HR-like lesion-inducing protein
- At3g23190
- AT4g14420/dl3250c
Sequence:
MRMLVLRTPTGPVSAVRFITKSKPSPFSSPDSWLLPAPNTHRSRPRVVLALSNPDGSVNSKPSTSASQIPSSGDETVFVGQDNVPLEGVIQFDKPSSTSSSNITKWGRVALLAGGDVLALLIFSAIGRFSHGFPVFSLDTLHTADPFIAGWFLSAYFLGGYAEEGRGMKGKSKAVVAAAKSWIVGTPLGIIIRSASSGHIPAYSFVLVTMGSTAVLLIGWRALLFSVLPTESKKKDDTYRKGSAFELFELLTSLIRRW
Protein: Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-like protein) (Receptor of activated protein kinase C) (Q10281)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be a receptor for protein kinase C in the regulation of actin cytoskeleton organization during cell wall synthesis and morphogenesis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P38011}. Membrane {ECO:0000269|PubMed:11263963}. Note=Associated with particulate fractions. {ECO:0000269|PubMed:11263963}.
Interaction partners:
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein eL14
Sequence:
MPEQLVLRATLEGHSGWVTSLSTAPENPDILLSGSRDKSIILWNLVRDDVNYGVAQRRLTGHSHFVSDCALSFDSHYALSASWDKTIRLWDLEKGECTHQFVGHTSDVLSVSISPDNRQVVSGSRDKTIKIWNIIGNCKYTITDGGHSDWVSCVRFSPNPDNLTFVSAGWDKAVKVWDLETFSLRTSHYGHTGYVSAVTISPDGSLCASGGRDGTLMLWDLNESTHLYSLEAKANINALVFSPNRYWLCAATGSSIRIFDLETQEKVDELTVDFVGVGKKSSEPECISLTWSPDGQTLFSGWTDNLIRVWQVTK
Protein: Retinol binding protein 3 (G1N7C9)
Organism: Meleagris gallopavo (Wild turkey)
Interaction partners:
Sequence:
MAKILLDNYCYPENLVGMQEAIEQAIKSGEILDISDPKMLANVLTAGVQGALNDPRLIISYEPSPPAAAKQEAETYLTREQLLSLIEHIVIYDKLEGNVGYLRIDYVIGQEVVEKVGAFLVDKVWKTLINTSALVIDLRYSTGGQISGIPFIISYLHEADKMLHVETVYNRPSNTTTEVWTLPKVLGERYSKDKDVIVLISHHTTGVAEDVAYILKHMSRAIIVGEKTAGGSLDIQKLRIGPSNFYMMVPVSRSISPLSGGGQSWEVSGVMPCVASEAEQALQKSLDILAVRRAVPGTLSRLADILKDYYSLVERVPVLLRHLATSDFSSVQSVEDLATKLNTEMQTLSEDPRLLVRAMMPGETAALPAEMPIAMATNLPDNEQLLHALVDTVFKVSVLPGNVGYMRFDEFADASVLDKLGPYIVKKVWEPLQNTENMIMDLRYNPGGPSSSAVPVLISYFQDPTASPVHLFTTYDRRTNHTQEHNSQAELLAQTYGAQRGIYVLTSRHTATAAEEFAYLMQSLGRATLIGEITAGSLSHTRTFPLLQPEQGITCGLTITVPVITFIDNHGESWMGGGVVPDAIVLAEDALEKAEEVLAFHRKMGMLLESTGQLLEAHYAIPEVAEKASVMLNTKRLQGGYRSAVDFETLASQLTSDLQEASGDHRLHVFHSHVEPTLEEQLPNMIPSPEELSYIIDALFKIEVLPGNLGYLRFDMMAEAETVKAIGPQLVHIVWNKLVDTDAMIIDMRYNTGGYSTAVPILCSYFFEPEPRQHLYTVFDRSTSRSTEVWTLPKVTGKRYGSLKDIYILTSHLSGSAAEAFTRSMKDLHRATVIGEPTVGGSLSVGIYRVGNSSLYASIPSQVVLSPVTGKVWSVSGAEPHITIQASEALAVAQHIANLRAQVPQIVKTVGKLVAENYAFVDIGTDIASNLTESINKENYKRINSEKELARKLTAILQTLSDDEHLKMLYIPEHAKDSIPGIVPKEIPSPEVFEDLIKFSFHTNVLENNIGYLRFDMFGDCELLTQVSDLLVEHVWKKIVHTDALIIDMRYNIGGYTNSIPILCSYFFDEGHQVLLDKVYDRPSDSVKEIWTQPQLRGERYGSQKGLIILTSAVTAGAAEEFVFIMKRLGRALIIGEQTSGGSHSPQTYQVDDTNFYIIIPTAQSVISAESSSWEGKGVPPHMETPAVTALIKAKEVLSAHLHNSR
Protein: Lipid phosphate phosphatase 1 (AtLPP1) (EC 3.1.3.-) (Phosphatidic acid phosphatase 1) (AtPAP1) (Prenyl diphosphate phosphatase) (Q9ZU49)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a general role in cellular responses to stress, may be by attenuating the signal produced by phospholipases. Exhibits both diacylglycerol pyrophosphate (DGPP) phosphatase and phosphatidate (PA) phosphatase activities. Substrate preference is diacylglycerol pyrophosphate > phosphatidate.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Phosphatidate phosphatase PAH1
- Phosphatidate phosphatase PAH2
- Choline/ethanolaminephosphotransferase 2
- Phospholipid:diacylglycerol acyltransferase 1
- Diacylglycerol O-acyltransferase 2
- Choline/ethanolaminephosphotransferase 1
- Diacylglycerol O-acyltransferase 1
- Putative phospholipid:diacylglycerol acyltransferase 2
- Diacylglycerol O-acyltransferase 3
- Triacylglycerol lipase SDP1L
Sequence:
MTIGSFFSSLLFWRNSQDQEAQRGRMQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENMESGTSTAPR
Protein: Cx9C motif-containing protein 4, mitochondrial (Q3E7A9)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:19703468, ECO:0000269|PubMed:22984289}. Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery.
Interaction partners:
- FACT complex subunit SPT16
- Histone H2B.2
- Histone H2B.1
- ERMES regulator 1
- Histone H4
- Histone H2A.Z
- Ubiquitin-ribosomal protein eS31 fusion protein
- Mitofissin
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- Actin-related protein 5
Sequence:
MSNPCQKEACAIQDCLLSHQYDDAKCAKVIDQLYICCSKFYNDNGKDSRSPCCPLPSLLELKMKQRKLTPGDS
Protein: Putative xyloglucan endotransglucosylase/hydrolase protein 13 (At-XTH13) (XTH-13) (EC 2.4.1.207) (Q9FKL8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May catalyze xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity).
Subcellular location: Secreted, cell wall {ECO:0000305}. Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Fasciclin-like arabinogalactan protein 6
- Leucine-rich repeat extensin-like protein 1
- Extensin-like protein
- Amino acid transporter AVT6A
- Proline-rich extensin-like family protein
Sequence:
MAAFTTKQSLLLLSLLLLISLSAGSFYDNFDITWGNGRANIVESGQLLTCTLDKISGSGFQSKKEYLFGKIDMKMKLVAGNSAGTVTAYYLSSKGETWDEIDFEFLGNVTGQPYVLHTNVFTGGKGNREMQFYLWFDPTADFHTYTVLWNPLNIIFLVDGIPIRVFKNNEANGVAYPKSQPMKIYSSLWEADDWATQGGKVKTDWTNAPFSASYKSFNDVDCCSRTSLLNWVTCNANSNSWMWTTLNSNQYGQMKWVQDDYMIYNYCTDFKRFPQGLPTECNLN
Protein: RE73786p (Q8IGK2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRTEAAVSCFLLVLHRVCCQSGNDESWLSPDPAWSDLVNDINQPGELCQCPTCPDVSPVAMEDAVALTYFKKFVNLLFQRKRFQYDVMSAVHKRPLLFSLIPSQLDELERVQDARDLDVLLTKILESAEEAPLFNGRSGCSYVRHGFFSLLVDIFKDVIELTQTTEVKFILYATLAIALVVIVHKRFRVGLISIVLGGVFLCGYIQTYLECNRELDIDRMIEVVNHHHEPESSWFGRLLGYIYQASPKTKKIEMIKKSAKISISICMPDQVFFMYMNNIFIKQLEIMIEKVSVTMTKLSSGLSFPYNLLAPVLLVFLVGYTIKLCFKYILSPRAWASLLHKPAPQGTPTIHQSINARAPEGDSISGDNLKMLLNVINVRNVPKESLQRIPDVSGVQELEEKQEAPTTPSKKENLDESDSSSKSKSKSCVAEDEGFTLVDDHEDNNIDNV
Protein: Inner membrane transport protein YdhP (P77389)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized protein YnhF
- Inner membrane protein YbcI
Sequence:
MKINYPLLALAIGAFGIGTTEFSPMGLLPVIARGVDVSIPAAGMLISAYAVGVMVGAPLMTLLLSHRARRSALIFLMAIFTLGNVLSAIAPDYMTLMLSRILTSLNHGAFFGLGSVVAASVVPKHKQASAVATMFMGLTLANIGGVPAATWLGETIGWRMSFLATAGLGVISMVSLFFSLPKGGAGARPEVKKELAVLMRPQVLSALLTTVLGAGAMFTLYTYISPVLQSITHATPVFVTAMLVLIGVGFSIGNYLGGKLADRSVNGTLKGFLLLLMVIMLAIPFLARNEFGAAISMVVWGAATFAVVPPLQMRVMRVASEAPGLSSSVNIGAFNLGNALGAAAGGAVISAGLGYSFVPVMGAIVAGLALLLVFMSARKQPETVCVANS
Protein: Protein RST1 (Protein RESURRECTION 1) (Q7XZF5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cuticular wax formation. Required for the synthesis of alkanes from wax precursors. May play a role in acyl-CoA reduction to aldehydes. Is repressed by FREE1 and functions downstream of FREE1 to negatively regulate multivesicular body (MVB) biogenesis and vacuolar transport. Together with CER16/RIPR, acts as cofactor of the cytoplasmic exosome and connects the cytosolic RNA exosome to the SKI complex. Acts as post-transcriptional gene silencing (PTGS) suppressor. RST1 can, like CER16/RIPR, suppress the production of small interfering RNAs (siRNAs) from the CER3 locus, which is involved in cuticule membrane and wax production, and in the typhine and sporopollenin biosynthesis of pollen.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19625635}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000269|PubMed:31221737, ECO:0000269|PubMed:31455787}.
Interaction partners:
- DExH-box ATP-dependent RNA helicase DExH11
- Tetratricopeptide repeat protein SKI3
- Maternal effect embryo arrest protein
- At4g28210
- Exosome complex component RRP45B
- Glycine-rich protein family
- Exosome complex component RRP45A
- Protein ECERIFERUM 16
- Protein PELOTA 1
- Protein PELOTA 2
Sequence:
MASYATLLEKTRVPQPSIQRFAVISVFSKLRSAPEQFGSEAEAGREAISFCLTSESITVVDQSVHELCRLVSDSVLDLSRGLLELQSALEGCDSKLVSLFVKGLGFLIRIGYERNNGNWKFNSTENHPFVRIQSSRVETQTELLHQVSLFVMHNRRLGMVGVCEFLEPFLNFTILRIPLSDSSSSLFARELISSMASLCCSSRHEALPIFRLLMRCLKYIPGNNLEVIVKILVDAYTVVVRDLVGTGLEVTEVHLLGVQLVDGVLFLCASPHVQTTEQESVIESLKHLLAVQKDLGLAYSHDLSLVVLSLVFMLAKSTVEHEQLCILKFLLFLLKWKTESENLSVKDAAGSSVESLLLFPITALMSSPSKSIKVAASKVLSIVENFLVTVSNAPKIEVHTSKGDSPLSRVGSVVFRFMQQLWHQNDYTPSTSSFLRVAYTNGSEKQETYLGPVTWNSLLREHAERFWDKKKLSASFCLSQEIPILLGAVAGVMVMHPSLGADAIGSLTIIGGIDSKMSVPLLLAVLYFSNLLSRTNVPCQSLLSKLLGLLPSLAAQQVMIPLVVQTITPMLRKDAKGLLYATAIRLLCQTWVVNDRAFSSLQEVLRPQGFIEYISERHICISMAASIHDVCKRHPDRGVDLILSVQACIESQNCPVRALGFQSLSHLCEADVIDFYTAWDVIKKHAQHIKLDPLLAYSVCHLLKWGAMDAEAYPEDAENVLNILWEIGSSMQKPHDSQWTKARVSAIVALGQYEVSFMENKFSDFNKNCTYLLFSETNAEILNALEDLSIKIMIHEHSVRRRYVREKKVPGSKIEKLLDVIPQVIFPAGKEIKTGELPGAALLCLSYNPRDVKFGSSRSFHDVHFQYEEAFRVVVKSLQLSRNISLALISLQSLKAFMRRWMRANILSIDATTKELSSDKTSKATNNIMKSLVHMAEEALPRCAENIALALGALCAALPAASHNIKASASKFLLSWLLEHEHEHRQWTAGISLGLISSSLHVTDHKQKFQNISGLLEVLCSSKSTLVKGACGVGLGFSCQDLLTRTEASASSDIDSDSYRNQEERLLGRIVRLLSSILHGFLHTPCDILESLSALFPPGEEDNVIGLPQLLDESSDDFDDDTWGIAGLIIGLGMSVGAIYRAGKKDAVVKIKNLIVSWIPYADSLKQTSGSNSKVSVRLFSVGSCLALPIVITFCQKVELFDAHEVDDIIGCFKDLISELLIVRKSGALRKRLLMASCIGAGDLLGSVLNEGIHPVKIESVKELLELFKKCYSGLYPPVAHFGGMLGVVNVLGAGAGNLVYSHPRPRAPPASSEENEISYVSGPLLSNAYFTQQLTPVVQEIFLIAQNTKDRQLQHYAAWAISILRTYMRSGESSSLSNENQSDDSDRNSISHNVPEHTMVMKLAQGLTNPSFPLAGSPLNIGTMASALRCLSHAPRLPNLDWGATIRRLMKQETQTDVTQSGDVPKEITLREECFKFSLAHASEFDELLAFLDELSELSRFKALEESLQSCLLCHLGGLMRIFSGSRMNKLFDDVSCFVVSLSSDQTYSCDQKSSLRVSCWKGLSQCLEETSLESSEYVTKIEKCIELLFAVLPVASQSPRADQMGSVKEWSEAVTCLQKSHRDWLYKFLQVSNLEPGNEKTNFQGDLKKIQAKAKLAKLGSVPFSELGKLKAIILNCEESDIWDVLIEIVAALHHAEGGIKRQWLIDAVEISCVSSHPSTAIIFVGLLSSICCEYMPFLNLDRSTVLSDMSVTVTSLLSDPSYEVVTEPFISFLWTSLERVYSFATESDANARLSSQQIAQSERDKAPMLVKVMHYICVAFRDHLPLEKQLRLASMDMS
Protein: ferroxidase (EC 1.16.3.1) (B3KTA8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG
Protein: Phloem protein 2-A13 (F4JD33)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGANISGGSPEFDRNDDVYSRKLRLVDLPENCVALIMTRLDPPEICRLARLNRMFRRASSADFIWESKLPANYRVIAHKVFDEITLTKLIKKDLYAKLSQPNLFDDGTKQELWIDKNTGRLCLSISSKALRITGIDDRRYWSHIPTDESRFQSAAYVQQIWWFEVGGEFEIQFPSGTYSLFFRIQLGKTSKRLGRRICNSEHIHGWDIKPVRFQLATSDNQQAVSLCYLNNNPGSWSHYHVGDFKVTNPDVSTGIKFSMTQIDCTHTKGGLCIDSVLILPKECAKEVIGSQ
Protein: Sr-CI (Q6V6S2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
EFFWTLAVIVIYCIGHIHGRCERSIDLDNGSINYRQRNVVRFRCNRGYTLQGTVMQTCDRDGRLRGEKPFCASRGCARPEDPENGHVENLSLRADVVCHDGYVLVGGRTAYCDGERWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFSTTTEPTAPTGSNEQPLVYDMMSCSGRCGTSISASNITNNGIVMGCGCNDECLSDETCCLNYLEECTKELLTTTEDDISSLPPTVTSTSTSTTRKSTTTTTTSTTTTSTTTTKRPTTTTTTTKATTTKRTTTTKKPTTTSTTPKPTTTTSTTPKSXXXTTSTTSTTSTTPTTTTTINVFTTKKTTIMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIEGHMDTSGSTPNPALVVLYLLLGIVLVVVLANVVNRWIIPITGSKTSSEKAVRFKKAFDSLKKQRKRNS
Protein: AP2 domain transcription factor, putative (Q8I531)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDKGEGDKDNMNKNGNVYDMMDNEKNEEVNYIINEVDSSNDCKNELIKMNYDNNNNDNNNNNNNNNNDISYNVLNSNSVDTKNMENSCKNYVYDKDIENRDTYDNSNNKSNKSDDVDNKTGDISMNKNKLVNTNIYNSEENIYPCTYNTVVENNAYLKNIDIINTIENVEDNNMKNDVCNENNNIINNLYVDNDNWEKKNYVGLTEKLNCLKLEKTNEILEFNKTLDTSKDTQDINVVNEKLSVESNKNNVISNMNNIDSIDNINKMDNIDCIDNMNNIEKQSRKRKKNKLSDKKNLLNNEEYDNKENYDNLHVGNNYINTKDEINKVIQNINLLKALNTNDQKVNELNMDILNKSNEHNDNNEISKQLLDNIILLNSLSKYMNKDDINKQAKEKMKNRISKKKMTLEGTQLCKINKEQNDNMLNENNNIDDDNNDQHSKLSDYDNNMMNPHGVLNNSSGEIISSNCSNHLNYNNNDNNNDNNNNNNIIINKDVCNNKKNKKNSKKQTILCAKNNKGILENEDNKQLNDIRNKIYELTTNNYNSLNEANNENLQKKILLASGLLSSTDIMNPTDSEANNPLYNNFDKDTLLLINQMKDEEKHVLRNYLMNDANNKIGMGTRIVSKRKKQGSNLVNSNNNMNNLNDLNNNYEMKHNREYVGDNNVTTSNDNMNNNNNINISKKKKKINNIMDDKTQDLLDYQNTANLLNNVLNNNEKDVRNISMNILKNNINACNNDEEIIKALINNIGYSHEHNNNIVGNVKNIINLNRGKDNSLNEFSIVNDYIANIYECAQKDYLHNDKNNKNKNNIHMDNPLASNLININREEQMNFVNRLNMLMNEADINKKGLLEAYMRKYSNININGNNNINNNSNNNNLQSLNNQENILNNEQDNTSLSSQEKKLSYNDMLLNLKKRNVLEEFPFNFVKQKDDSAKNTMNDSSDTQVDIHMDHGFKEGNKKQEKLNSYVQEKFNYEVEKGENVQGEEEKYKQKYLTNEDKNVNVNNDDDDDNYNNSSRSNRKNCDKNKKTNDNNMSSEEIEHNDEKHNENYFKEWYKNISDQVRKLLIESGTNKNVFTENEKNKLLLNIAKEYLLKNNVNEKKKKKHTKNKNELNSNVENHNVFSDQYDDINNVLLNMQNGNINDITNKNIMNYEHNSTSIHPTIASTLFDINHENPREHIKSECSTINNNYNNNNYNNNKNYYLDYIKRLTQNNNNNENLLNIFENSKKYKKKNLSNTSLNSLNNEINEINEILNEKFETTESFDKYENSQQNIMKNKYNSNNINNNINSNNNIHNDEEERNILCNTNYQVNIKNDVKEEKVKERKVRKSRKNQNFVEDKKKKKNKDNNLNNGDSNNTHNKNNNTYDNNTHDNIYYDQIKTLQELHYQNAIVNSLMNGNNIEVCNMNNSKDIFKKKKNEDNEYINYKEQNNDERKKKMKDNNKGNKVDKKKKDEEFFNHINVLKVRDNDISHSNNNNDDDHDDNNNDNNNNIINNNNDDKFTHNINVLNNNEEKINIPYKPNEHKINIMIDESHFSGKEKELFIKGKETLLLEGMNDGKLDDDIENIDMTRNIKKINLYNIYNNKNDDKDNILDNENREGLYLCDVMKNSNELKRINDNFFKLHSNLASNLLSTSTSGSFGNDNYKSTPLNFDMNKLPSNNTFNNLYYMDENIITNNINVIPLVNKNYSDISSSYDIKKKNLHKNKKKHKNHINDNNIINVDYNMKGADNINNINSNMINVKNMNSNDEKPTTSTENMFPSHSTNINDSNIVKVVDSHDSINNHEEGLVNALNTIKADKSNGENSYSILDSNDVMIKKLMLKNNLLFEHLQKNGKFNKDENIKNASQSSLHSNIIRNLTLTNNFQNDYFYNGVKNGSFNNVLNKEKKMMNSYDEQQLKEKIASLKEQNENILNKKMLFKNKSYSDNDNFLSFYLKRKVSSFSDYNKESDNNSYLTKQKRKRKNENINYDKNKEFLVNRTNSLNIKRVRSGPLDNSQNVSQSNVHTYGTAKEIIDVDVLDENMNSNNSYNIKGGDNIISSNFTDPLKFTETSFDVQKESLIKESNENQTVLKEKDENLVDVKDDKTNQMSNVTTIGTSNLAESTTKNEIDIKVCTLINCPTHNPQNYVKSNGKRGESLGDGMELKEENDDLKRIPGVYYDKNSQRWFGEHKINGVKCAQSFAVKKHGCEEAKRLAIEWKKARIRGEVWDRFINKKKKNTNNNNNNNNNNNNNNSNNNSNNNNNSSNNNNNNNNNNSGSNSNNNSLKGSKSNRPSVEELRLKYLSMSKNMPKVRGVWFNSTPQRMGWVGQAYKKCKRIERIFSVNKYGFEGARKLAIAFRNSQKPANEDSDDDSWSKEDKINIKNCDENSNNYDYKNNFLVSMNTIKNNGSNIMSNDNNINNHSNNSNDNNHHMDNNLEAQIENNTDMIMDSNMDNDIDMNIDKKNIINKHNNHDENNKDMRINLCRDAILFILHDLETILELNIPMLSKNVNMYKLCIKHHLNYLTLIKNEEQIIPYLNVFGDYIQRCILPTDLPYAELYVLIDSLIHNEILPSYDHKENFCEYVAVEDPGIITPSMLL
Protein: Disease resistance protein (TIR class), putative (Toll-Interleukin-Resistance (TIR) domain family protein) (Q9SKM4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTFFSPTQVFLNYRGEQLRRSFVSHLIDAFERNEINFFVDKYEQRGKDLKNLFLRIQESKIALAIFSTRYTESSWCMDELVKIKKLADKRKLHVIPIFYKVKVEDVRKQTGEFGDNFWTLAKVSSGDQIKKWKEALECIPNKMGLSLGDKSDEADFIKEVVKAVQCVVATIGLEEEENHFGKKKRKDCKCELPDLKKSRTKKL
Protein: Tyrosinase (EC 1.14.18.1) (Albino locus protein) (Monophenol monooxygenase) (P11344)
Organism: Mus musculus (Mouse)
Function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Subcellular location: Melanosome membrane {ECO:0000250|UniProtKB:P14679}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P14679}. Melanosome {ECO:0000269|PubMed:26620560}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000269|PubMed:26620560}.
Interaction partners:
- Melanocyte protein PMEL
- Melan-A
- Tyrosine 3-monooxygenase
- P protein
- Aromatic-L-amino-acid decarboxylase
- Microphthalmia-associated transcription factor
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
- Amine oxidase
- Thyroid peroxidase
- Aspartate aminotransferase, mitochondrial
Sequence:
MFLAVLYCLLWSFQISDGHFPRACASSKNLLAKECCPPWMGDGSPCGQLSGRGSCQDILLSSAPSGPQFPFKGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFGGPNCTEKRVLIRRNIFDLSVSEKNKFFSYLTLAKHTISSVYVIPTGTYGQMNNGSTPMFNDINIYDLFVWMHYYVSRDTLLGGSEIWRDIDFAHEAPGFLPWHRLFLLLWEQEIRELTGDENFTVPYWDWRDAENCDICTDEYLGGRHPENPNLLSPASFFSSWQIICSRSEEYNSHQVLCDGTPEGPLLRNPGNHDKAKTPRLPSSADVEFCLSLTQYESGSMDRTANFSFRNTLEGFASPLTGIADPSQSSMHNALHIFMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLLEVYPEANAPIGHNRDSYMVPFIPLYRNGDFFITSKDLGYDYSYLQESDPGFYRNYIEPYLEQASRIWPWLLGAALVGAVIAAALSGLSSRLCLQKKKKKKQPQEERQPLLMDKDDYHSLLYQSHL
Protein: SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine) (P16975)
Organism: Rattus norvegicus (Rat)
Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2322281}. Note=In or around the basement membrane. {ECO:0000250}.
Interaction partners:
- Albumin
- Osteocalcin
- Vascular cell adhesion protein 1
- Osteopontin
- Lumican
- Collagen alpha-1
- Decorin
- Collagen alpha-2
- Stabilin 1
- Collagen alpha-1
Sequence:
MRAWIFFLLCLAGRALAAPQTEAAEEMVAEETVVEETGLPVGANPVQVEMGEFEEGAEETVEEVVAENPCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIAPCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALEEWAGCFGIKEQDINKDLVI
Protein: Unfolded protein response-inducible protein 1 (UPR-L-inducible protein 1) (P43604)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the unfolded protein response (UPR), a transcriptional response which up-regulates genes that enable cells to cope with misfolded, endoplasmic reticulum-retained proteins. UPR is part of the endoplasmic reticulum quality control (ERQC) which prevents the exit of misfolded secretory and membrane proteins from the endoplasmic reticulum.
Interaction partners:
- Uncharacterized membrane protein YIL089W
- Uncharacterized protein YOR289W
- Uncharacterized protein YBL039W-B
Sequence:
MTPYAVAITVALLIVTVSALQVNNSCVAFPPSNLRGKNGDGTNEQYATALLSIPWNGPPESLRDINLIELEPQVALYLLENYINHYYNTTRDNKCPNNHYLMGGQLGSSSDNRSLNDPQTMLWPEKKEDEKNCQETFKGACSCTKRFCKGYFSVNIFGINLNISYSSGK