wanglab/gogpt-training-data huggingface dataset:
Protein: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10) (P0CB78)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Interaction partners:
Sequence:
MTLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLAYPETRTLIENGFVEAIKEAFPEVEVIAGTATAGIPHGAIIADKMDLPFAYIRSKPKDHGAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKADKNFADAGVKLVTLSNYSELIHLAQEEGYITPEGLDLLKRFKEDQENWQEG
Protein: Probable plastidic glucose transporter 3 (Q2V4B9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the efflux of glucose towards the cytosol.
Subcellular location: Plastid, chloroplast membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Acireductone dioxygenase 2-requiring) 2)
- At2g39500/F12L6.16
- Acireductone dioxygenase 1-requiring) 1)
- Protein NDL1
- Guanine nucleotide-binding protein subunit beta
- LOB domain-containing protein 21
- Probable glycosyltransferase STELLO1
- 2-oxoglutarate-dependent dioxygenase DAO
Sequence:
MDSVRRTYTIMRGRHIDKRVPSKEFLSALDKAETAVRLPTGTGKDCGNPSWKRSLPHVLVASLTSLLFGYHLGVVNETLESISIDLGFSGNTIAEGLVVSTCLGGAFIGSLFSGLVADGVGRRRAFQLSALPMIVGASVSASTESLMGMLLGRFLVGIGMGIGPSVTALYVTEVSPAYVRGTYGSSTQIATCIGLLGSLFAGIPAKDNLGWWRICFWISTVPAAMLAVFMELCVESPQWLFKRGRAAEAEAVFEKLLGGSYVKAAMAELVKSDRGDDADSAKLSELLFGRSFRVVFIGSTLFALQQLSGINAVFYFSSTVFKKAGVPSASANICVGVCNLLGSTVAVVLMDKLGRKVLLIGSFAGMAVSLGLQAIAYTSLPSPFGTLFLSVGGMLLFVLSFATGAGPVPSLLLSEICPGRLRATALAVCLAVHWVINFFVGLLFLRMLEQLGSVLLNAIFGFFCVVAVIFVQKNVVETKGKSLQEIEISLLSSTQ
Protein: Uncharacterized protein (Q57XF9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDDVKRKSAMLMTKGIIELRQSPPALVCTIRRFKHPMSGKEVTLYPVPNIAAPHYFRRVLDAHHLTNNFDKVLCEDGRLPFQAGTALARRHEVFKRLLPFLSLRPVVVNGDKFDGIVERDPLESRMAYQMLLDGADPPVDPRARRAIERIEGYADATKTVCPWGVYHLVYMTYRLRTLGYTVESEEELEVVGMKEVMVLGCFMGITTFWMMYALYRMLFGF
Protein: Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1) (P04755)
Organism: Drosophila melanogaster (Fruit fly)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Nicotinic acetylcholine receptor alpha3, isoform B
- Acetylcholine receptor subunit alpha-like 1
- Nicotinic acetylcholine receptor alpha6, isoform E
- Nicotinic acetylcholine receptor alpha7, isoform E
Sequence:
MESSCKSWLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQVMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEIYRGK
Protein: AUGMIN subunit 7 (Q0WTP1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Contributes to the assembly of the acentrosomal spindle and phragmoplast microtubule arrays as part of the augmin complex. Regulates the association of gamma-tubulin with the spindle and phragmoplast microtubules.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22505726}. Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:22505726}. Note=Preferentially localizes to microtubules minus ends. {ECO:0000269|PubMed:22505726}.
Interaction partners:
- AUGMIN subunit 4
- AUGMIN subunit 5
- AUGMIN subunit 6
- AUGMIN subunit 3
- AUGMIN subunit 1
- AUGMIN subunit 2
- AUGMIN subunit 8
- Putative defensin-like protein 135
- Uncharacterized protein At4g06744
- WAT1-related protein At4g08300
Sequence:
MAAKQMEEIQKKLRLLSYPRANAPAQSLLFAGMERYALLEWLFFKLLGDKSPFSQQNLQGDAGVRDEETVRIQYLAEIAKFLGITPTVDIEAIQGHGTYEDRMEMLRNIVDLVEASLFSDNQEWSIDEQVAKDIQLIDAIAERQSLIFSEECKLFPADVQIQSIYPLPDVSELETKLSEQAKILSNLQQKVDDLAAKHAYNPDEEYTEVESQLRARLESFLETARAFNTIYTKEIRPWTHMMEVPQLHGFGPAANRLLEAYNMLLKFLGNLKNLRDSHAALSIGSSGTVAGEPSSVTRIVSDCEAALTVLNRDLGILSASIAREQGERL
Protein: Toxin Tppa2 (Toxin Cocle-A1) (C0HLZ1)
Organism: Tityus pachyurus (Colombian scorpion)
Function: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
Subcellular location: Secreted {ECO:0000269|PubMed:29196122, ECO:0000269|PubMed:35024608}.
Interaction partners:
Sequence:
KDGYLVGNDGCKYSCLTRPGHYCASECSRVKGKDGYCYAWMACYCYNMPNWVKTWSRATNKCGKRK
Protein: Dual oxidase maturation factor 1 (P34298)
Organism: Caenorhabditis elegans
Function: Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Dual oxidase 1
- NAD
- Tetraspanin-15
- Peroxidase mlt-7
- peroxidase
- peroxidase
- Sodium-dependent multivitamin transporter
- Sodium-coupled monocarboxylate transporter 2
- Tetraspanin
- Tetraspanin
Sequence:
MWWFGGNPSPSDYPNAAIPNFNMHAFVIFSVFLIPLIAYILILPGVRRKRVVTTVTYVLMLAVGGALIASLIYPCWASGSQMIYTQFRGHSNERILAKIGVEIGLQKVNVTLKFERLLSSNDVLPGSDMTELYYNEGFDISGISSMAEALHHGLENGLPYPMLSVLEYFSLNQDSFDWGRHYRVAGHYTHAAIWFAFACWCLSVVLMLFLPHNAYKSILATGISCLIACLVYLLLSPCELRIAFTGENFERVDLTATFSFCFYLIFAIGILCVLCGLGLGICEHWRIYTLSTFLDASLDEHVGPKWKKLPTGGPALQGVQIGAYGTNTTNSSRDKNDISSDKTAGSSGFQSRTSTCQSSASSASLRSQSSIETVHDEAELERTHVHFLQEPCSSSST
Protein: 17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.1.-) (EC 1.1.1.62) (Hepatic retinol/retinal dehydrogenase) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 16C member 3) (Short-chain dehydrogenase/reductase 9) (Q7Z5P4)
Organism: Homo sapiens (Human)
Subcellular location: [Isoform 2]: Lipid droplet {ECO:0000269|PubMed:29562163, ECO:0000269|PubMed:30415504, ECO:0000269|PubMed:32973038}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VCR2}. Note=Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation. {ECO:0000250|UniProtKB:Q8VCR2}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:30415504}. Note=Does not localize to lipid droplets. {ECO:0000269|PubMed:30415504}.
Interaction partners:
- Transmembrane 6 superfamily member 2
- 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
- Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7
Sequence:
MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
Protein: Smad protein daf-8 (Abnormal dauer formation protein 8) (Q21733)
Organism: Caenorhabditis elegans
Function: Probably a receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta-like daf-7 signaling. Plays a role in TGF-beta-like daf-7 signaling in regulating entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions; partially redundant with R-SMAD daf-14. Plays a role in inhibiting mitosis and promoting a switch to meiosis in the germ line, perhaps by down-regulating lag-2 transcription in the gonadal distal tip cells (DTCs). In cooperation with orphan nuclear receptor nhr-69 modulates the Insulin/IGF-1-like signaling (IIS) pathway, perhaps by regulating expression of the potassium channel exp-2, which in turn modulates the secretion of the insulin-like peptide daf-28.
Subcellular location: Cytoplasm {ECO:0000255|RuleBase:RU361195, ECO:0000269|PubMed:20081192}. Nucleus {ECO:0000255|RuleBase:RU361195, ECO:0000269|PubMed:20081192}. Note=Localizes to the nucleus in a TGF-beta-like receptor daf-1 dependent manner. {ECO:0000269|PubMed:20081192}.
Interaction partners:
- Ski protein homolog
- Cell surface receptor daf-1
- Dwarfin sma.
- Dauer larva development regulatory growth factor daf-7
- Cell surface receptor daf-4
- Protein dbl-1
- E3 ubiquitin-protein ligase CHIP
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3
- FYVE-type domain-containing protein
- Dwarfin sma-4
Sequence:
MDDFPSPEPTDPRLEAMAQKVLEETIITEGDGTIYWALKVTRLLSRVAKKHQCFEAFYDAVIKGDPKTRCCPAHNEKLIGNFGRAIMCVLRAFRFPVIRYESQVKSILTCRHAFNSHSRNVCLNPYHYRWVELPTCQVPPIIVNKELDYGEPPIRTEDALDDWNQKDLKEEQVVASWDVPNVTMRGDEIKLLYDRYAAENGDFQYMNYGNFGSFDGSPCSSTTMSLGSSFASLLQQSNRQDDEEPGYYRSGLSSPASHAASPREFIPNGNDTISLDQEMMDDSEVSDIMHSENFSSENNGNRKPTYADGRPITPIEPRPLYRSSALELGDLSRQAGIYECVEYEESPSWLKLIYYEEGTMIGEKADVEGHHCLIDGFTASRTDSETRSRFSLGWYNNPNRSPQTAEVRGLIGKGVRFYLLAGEVYVENLCNIPVFVQSIGANMKNGFQLNTVSKLPPTGTMKVFDMRLFSKQLRTAAEKTYQDVYCLSRMCTVRVSFCKGWGEHYRRSTVLRSPVWFQAHLNNPMHWVDSVLTCMGAPPRICSSRT
Protein: BFN domain-containing protein (Q72DE6)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- PHP domain protein
- tRNA-2-methylthio-N
Sequence:
MVEMKVVGLSLDESTKAPILVLRREESDELLPIWIGAMEAMAISLALNNVDVPRPLTHDLLLHTLHALRAELVAVDLVDLREGTYFAELVLIAGGRQARVDCRPSDGIALALRAGVPILVREDVLRRAAEDRMRPMQDDSAVLRAPGDTTLGMTREQLDEPDEKELSDLLQSLDPETKYRM
Protein: Formate channel FocA (Formate transporter FocA) (P0AC23)
Organism: Escherichia coli (strain K12)
Function: Involved in the bidirectional transport of formate during mixed-acid fermentation. Functions to maintain relatively constant intracellular formate levels during growth, using different mechanisms for efflux and uptake of the anion. Has a strong preference for formate as a substrate in vivo and not other acidic fermentation products.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:20041954, ECO:0000269|PubMed:24659605, ECO:0000269|PubMed:33169422}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P0AC25}.
Interaction partners:
- Formate acetyltransferase 1
- PFL-like enzyme TdcE
- Formate dehydrogenase H
- Formate hydrogenlyase transcriptional activator FhlA
- Pyruvate formate-lyase 1-activating enzyme
- D-lactate dehydrogenase
Sequence:
MKADNPFDLLLPAAMAKVAEEAGVYKATKHPLKTFYLAITAGVFISIAFVFYITATTGTGTMPFGMAKLVGGICFSLGLILCVVCGADLFTSTVLIVVAKASGRITWGQLAKNWLNVYFGNLVGALLFVLLMWLSGEYMTANGQWGLNVLQTADHKVHHTFIEAVCLGILANLMVCLAVWMSYSGRSLMDKAFIMVLPVAMFVASGFEHSIANMFMIPMGIVIRDFASPEFWTAVGSAPENFSHLTVMNFITDNLIPVTIGNIIGGGLLVGLTYWVIYLRENDHH
Protein: Proteasome subunit alpha type-1 (Proteasome subunit alpha 6) (O44156)
Organism: Caenorhabditis elegans
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Proteasome subunit beta
- Proteasome subunit alpha type-4
- Proteasome subunit beta
- Proteasome subunit beta type-3
- Proteasome subunit beta
- Proteasome subunit beta type-1
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-6
- Proteasome subunit pbs-5
- Proteasome subunit alpha type-2
Sequence:
MFRNQYDGDVTVWSPQGRLHQVEYAVEAMKQGSATVGIKSETHAVIVALKRAQNDLSSHQKKVYEIDTHAGVSIAGLLSDGRILARYLQTECSSWRWDYKQAVPIKKLAESMQLKLQANTQYYGRRPFGVGILIAGYDKDGAHIIQTDPSAEVVSMHGTSIGARSQSARTYLERNVDNFEKSTPEQLIVHALLALRDTLPAEENLNAQNTSIGIVGKDSPFSLLEDAQVAVHLNQVSTHPRTTGGAAAAAAPGGAEPMQM
Protein: Metallo-beta-lactamase fold-containing protein ST1585 (Putative quorum sensing signal protein STK_15850) (Q970L2)
Organism: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
Interaction partners:
Sequence:
MPCRGLHSIPAGPVEFPEIATVYVMCGEKLTVMIDAGVSNSIADFSFLDKLDYIVLTHLHIDHIGLLPELLQVYKAKVLVKSGFKKYLTSEDGLKKLNESAEKVLGDLYYVYGGLEKKLDQDKVIEVEGNEEFDLGGYRMRLIYTPGHARHHMSVLVDDFLFTGDSAGAYFNGVVIPTTPPVIDYKMYMESLKRQIELKPKVVGFAHGGLVSPKIMEEHLKQMLSKEEIQINVDIGGVAGEILRKQIEVNLRGLRESKKSI
Protein: Tissue factor pathway inhibitor 2 (TFPI-2) (Placental protein 5) (PP5) (P48307)
Organism: Homo sapiens (Human)
Function: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.
Subcellular location: Secreted.
Interaction partners:
- Tissue factor
Sequence:
MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKKKMPKLRFASRIRKIRKKQF
Protein: Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) (Proteoglycan macrophage colony-stimulating factor) (PG-M-CSF) [Cleaved into: Processed macrophage colony-stimulating factor 1; Macrophage colony-stimulating factor 1 43 kDa subunit] (P09603)
Organism: Homo sapiens (Human)
Function: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}; Single-pass type I membrane protein {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}.; SUBCELLULAR LOCATION: [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
Interaction partners:
- Macrophage colony-stimulating factor 1 receptor
- Interleukin-34
- Granulocyte-macrophage colony-stimulating factor
- Pro-epidermal growth factor
- Epidermal growth factor receptor
- Granulocyte colony-stimulating factor
- Mast/stem cell growth factor receptor Kit
- High affinity nerve growth factor receptor
- Tumor necrosis factor ligand superfamily member 11
- Proto-oncogene tyrosine-protein kinase Src
Sequence:
MTAPGAAGRCPPTTWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQDVVTKPDCNCLYPKAIPSSDPASVSPHQPLAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQPRPSVGAFNPGMEDILDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLPASAKGQQPADVTGTALPRVGPVRPTGQDWNHTPQKTDHPSALLRDPPEPGSPRISSLRPQGLSNPSTLSAQPQLSRSHSSGSVLPLGELEGRRSTRDRRSPAEPEGGPASEGAARPLPRFNSVPLTDTGHERQSEGSFSPQLQESVFHLLVPSVILVLLAVGGLLFYRWRRRSHQEPQRADSPLEQPEGSPLTQDDRQVELPV
Protein: Protein EMSY-LIKE 4 (AtEML4) (Q08A72)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably involved in the regulation of chromatin states (Probable). Contributes to RPP7-mediated and basal immunity, especially against Hyaloperonospora arabidopsidis isolate Hiks1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9C7C4, ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Protein ENHANCED DOWNY MILDEW 2
Sequence:
MDCKSSDSSGTDDDLPPSHRVPRGGGGGRGGRVAGNGRPLNLPPSYPKMYDDLAADMEAQIHQIEKEAYISVLRAFKAQGDAISWEKESVITELRKELSLSNEEHRELLGRVNSDDTIRRIREWRQSGGMQPSMRNAAQVVHDTLPSPSVSASMKTHKPNQPIPSQPFASSSPSFHPQADPTHPFASSTAKRGPVPIVKGKKHKPVFPGSSSTKHAPYHPSDQPPRGQVMNRLPSVPASSSEPTNGIDPESFLGRRVRTKWPEDNTFYDAIITQYNPVEGRHALVYDIATPSETWEWVRLSEISPGDIEWIGEDPGLGNRYNGQGHGLNRTTGPNCVPQRGSGLEKNTIRKGFRTSQNGTGKKKHLDIRIRQTDVLIREVERVLRSHNPDPYEVERAKRVLEEHEHALVGAIAKLGDISDGENEGAFRR
Protein: SNAPC4 (snRNA-activating protein complex subunit 4) (I1V1W6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MASDDLXAQRDKIQREILALESTLGADSSIADQLSSDNSSDYESDDSGPTVXRVERDDLETERLRIQREIEELENALGADAALENVLQDSDHDTDSSEDSADDLELPQNVETCLQMNLVYQEVLKEKLAELEQLLIENQQQQKEIEVQLSGPGNSIFSVPGVPPQKQFLGYFLKPYFKDKLTGLGPPANEETKERMKHGSIPVDNLKIKRWEGWQKTLLTNAVARDTMKRMLQPKLSKMEYLSNKLCRAEGEEKEQLKAQIELIEKQIAEIRTLKDDQLLGDLQDDHDWDKISNIDFEGLRQADDLKRFWQNFLHPSINKSVWKQDEIYKLQAVAEEFKMCHWDKIAEALGTNRTAFMCFQTYQRYISKTFRRTHWTEEEDDLLRELVEKMRIGNFIPYIQMSHFMVGRDGSQLAYRWTSVLDPSLKKGPWSKEEDQLLRNAVAKYGTREWGRIRTEVPGRTDSACRDRYLDCLRETVKKGTWSYAEMELLKEKVAKYGVGKWAKIASEIPNRVDAQCLHKWKLMTRSKKPLKRPLSSITTSYPRNKRQKLLKTVKEEMFFNSSSDDESQINYMNSDESDDLAEDENLEIPQKEYVQTEMKEWIPRNAMVWTITPGSFRTLWVRLPTNEEELRESTKESGLGSDSSENSACPNDEPIXERNTILDRFGDVERTYVGMNTVVLHRRTDDEKAMFKVCMSDVKQFIQMKATEFAVKKKKKIKNKKRTLRDVFSLNTDLQKAVIPWIGNVIISTPANEAIFCEGDIVGIKAASIRLQKTSVFTFFIKAFHVDVNGCRTVIEIHKKLDIKMPLAINGNPKPTPISTSPKTVAVLLQQSKAASEHKKPAEPSQQPSLPPSQKPSLPPSVPPSQQPTLPPPSQPSQPPPQPPSLPPSQPPAQQPSLPPPQPPSLPPPLPPPQPPSLPPPQPPSLPTSQQQSLPPSQQHSLPPFQNPSLPPSQQPSLPPSKQPPQPLPVRQITTPTLIYPNNLVITNPNMEGEVQHLVFKGLLLPQQPSKAVSHIPLPVMQPKTPAQPIVVSKSPSVQDSNSVKSSKRICKPTKKAQALMEQSKVKSRKKEPQKQNQGNKNVVFPTVTLQTSPVIKILSPARLVQVTGLSPNFSSNQTINMPDKSLTIKSPQPCSSGNLHQSAPVVVHSSTNPTFVHSSVSNVSRDNLNVSSTINISPRVSRDALNPTSFLNSTTFPLPQNLSVQQSVQIVPQIPINVVHKATCTKAAKTSSDSSSDESVVKQHQLSPSTGRSIPPAVFNIQPNPSTPPTLSSGPVIFNPNNKVVAPKLCGLNVSSSQLPTVSTQKTKYRPIRPLGPLPVVAPPSRKVTSMSRIRAQSEGEPLISLRDLPAAGVNFDSHLIFPEKSSEVDDWMDGKGGIPLPHLDTSLPYLPPSAATIKTMTDLLRAKQPLLLAAKKVLPAQYQDECNEEVEVEAIRKVVAERFASNPAYLLCKARFLSCFTLPALLATINPCEERQLLSEDDEEDDHLATINPSEEHQSSTEDDEEDLQTNERSQPPTARTELNMNENEASAKQFSGIGPKRQRNQRIKRLIK
Protein: Probable O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE (P72047)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD
- Galactofuranosyltransferase GlfT1
- Bacterial proteasome activator
- Probable conserved transmembrane protein alanine and leucine rich
- Galactofuranosyltransferase GlfT2
- N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
- UDP-galactopyranose mutase
- Decaprenyl-phosphate N-acetylglucosaminephosphotransferase
- Phosphoribosyltransferase
- Arabinogalactan biosynthesis recruiting protein Rv3789
Sequence:
MSDPHHPHIQTHNAWVEFPIFDAKSRSLKKAVLGKAGGTIGRNNSNVVVIEALRDITMELNLGDRVGLVGHNGAGKSTLLRLLSGIYEPTRGWAKVTGRVAPVFDLGIGMDPEISGYENIIIRGLFLGQTRKQMQAKVDEIAEFTELGEYLSMPLRTYSTGMRVRLAMGVVTSIDPEILLLDEGIGAVDADFLRKAQSRLQNLVERSGILVFASHSNEFLARLCKTAIWIDHGVIRLAGGIEEVVRAYEGEDAARHVREVLAETQADRQNVQG
Protein: Moesin/ezrin/radixin homolog 1 (G5EFD6)
Organism: Caenorhabditis elegans
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}. Cell projection, rhabdomere {ECO:0000256|ARBA:ARBA00043944}.
Interaction partners:
Sequence:
MGTDRDPGDQKHPTTSQQPRDSKMQLAKVLLPDGVQKEFEVNKNSEGEALFRQVTRDLSIEEREYFSLCFYDKDEGTRHWLYNDKNIAKQIKGLPWEFSFEVKFYPTTPTTIVDDHARYYVFLQLRRDLLTGRLPATADTHSLLGSFVAQIEFGDAPAEMTDAYEQFIVASKLVPSAQANPETYKKIVDLHREMRGQTPSEAENQFLDHCKHLALYGIHLFKAISDKDKKPVDVGIGAAGINIYQDEQKTHSFSWQNIIKIGYRRTYFSIKLKAGTVEKNEKTLYFKLPNHVAAKRTWKCAVEHHTFFRLIQPEDKTHKSFFNFGSQRFRYQGRTQFQTKIASQMFDKPSTVDRAPSAMSQPIATAENQKLQTLNLTDSELEQRQFERDKSNKKDKKKRKKGENETSGETSDSEHDEKREFAIVEFEPESGQPYTTVSTWQETSDLPEQVEVYTDENGRQITRTVKSSQVKHTVQTQSFQNYIVDGDQVPVGVVDVERSREQLTPLGQKASSSTSSDVQNGGGENGGIVETQTRTMTYEAQGGENSAPPGWAEEGLGEYVSSKSVTQGNRTIETITYKTEKDGIVETHVEHRVTIHSDGDIDHDAELSQAILEATQMNPDMVVEKIEVRQETTQ
Protein: Cilia- and flagella-associated protein 65 (Coiled-coil domain-containing protein 108) (Q6ZU64)
Organism: Homo sapiens (Human)
Function: Plays a role in flagellar formation and sperm motility.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:33472045}; Single-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:31413122, ECO:0000269|PubMed:33472045}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:31413122}. Note=Expressed in flagella midpiece and acrosome of mature spermatozoa. {ECO:0000269|PubMed:31413122, ECO:0000269|PubMed:33472045}.
Interaction partners:
Sequence:
MFTLTGCRLVEKTQKVENPSVSFASSFPLIPLLLRGKSVQKKQAESKSQIKLHTQSAPFGLCPKDMMLTQAPSSVVRSRNSRNHTVNSGGSCLSASTVAIPAINDSSAAMSACSTISAQPASSMDTQMHSPKKQERVNKRVIWGIEVAEELHWKGWELGKETTRNLVLKNRSLKLQKMKYRPPKTKFFFTVIPQPIFLSPGITLTLPIVFRPLEAKEYMDQLWFEKAEGMFCVGLRATLPCHRLICRPPSLQLPMCAVGDTTEAFFCLDNVGDLPTFFTWEFSSPFQMLPATGLLEPGQASQIKVTFQPLTAVIYEVQATCWYGAGSRQRSSIQLQAVAKCAQLLVSIKHKCPEDQDAEGFQKLLYFGSVAVGCTSERQIRLHNPSAVNAPFRIEISPDELAEDQAFSCPTAHGIVLPGEKKCVSVFFHPKTLDTRTVDYCSIMPSGCASKTLLKVVGFCRGPAVSLQHYCVNFSWVNLGERSEQPLWIENQSDCTAHFQFAIDCLESVFTIRPAFGTLVGKARMTLHCAFQPTHPIICFRRVACLIHHQDPLFLDLMGTCHSDSTKPAILKPQHLTWYRTHLARGLTLYPPDILDAMLKEKKLAQDQNGALMIPIQDLEDMPAPQYPYIPPMTEFFFDGTSDITIFPPPISVEPVEVDFGACPGPEAPNPVPLCLMNHTKGKIMVVWTRRSDCPFWVTPESCDVPPLKSMAMRLHFQPPHPNCLYTVELEAFAIYKVLQSYSNIEEDCTMCPSWCLTVRARGHSYFAGFEHHIPQYSLDVPKLFPAVSSGEPTYRSLLLVNKDCKLLTFSLAPQRGSDVILRPTSGLVAPGAHQIILICTYPEGSSWKQHTFYLQCNASPQYLKEVSMYSREEPLQLKLDTHKSLYFKPTWVGCSSTSPFTFRNPSRLPLQFEWRVSEQHRKLLAVQPSRGLIQPNERLTLTWTFSPLEETKYLFQVGMWVWEAGLSPNANPAATTHYMLRLVGVGLTSSLSAKEKELAFGNVLVNSKQSRFLVLLNDGNCTLYYRLYLEQGSPEAVDNHPLALQLDRTEGSMPPRSQDTICLTACPKQRSQYSWTITYSLLSHRDNKAGEKQELCCVSLVAVYPLLSILDVSSMGSAEGITRKHLWRLFSLDLLNSYLERDPTPCELTYKVPTRHSMSQIPPVLTPLRLDFNFGAAPFKAPPSVVFLALKNSGVVSLDWAFLLPSDQRIDVELWAEQAELNSTELHQMRVQDNCLFSISPKAGSLSPGQEQMVELKYSHLFIGTDHLPVLFKVSHGREILLNFIGVTVKPEQKYVHFTSTTHQFIPIPIGDTLPPRQIYELYNGGSVPVTYEVQTDVLSQVQEKNFDHPIFCCLNPKGEIQPGSTARVLWIFSPIEAKTYTVDVPIHILGWNSALIHFQGVGYNPHMMGDTAPFHNISSWDNSSIHSRLVVPGQNVFLSQSHISLGNIPVQSKCSRLLFLNNISKNEEIAFSWQPSPLDFGEVSVSPMIGVVAPEETVPFVVTLRASVHASFYSADLVCKLYSQQLMRQYHKELQEWKDEKVRQEVEFTITDMKVKKRTCCTACEPARKYKTLPPIKNQQSVSRPASWKLQTPKEEVSWPCPQPPSPGMLCLGLTARAHATDYFLANFFSEFPCHFLHRELPKRKAPREESETSEEKSPNKWGPVSKQKKQLLVDILTTIIRGLLEDKNFHEAVDQSLVEQVPYFRQFWNEQSTKFMDQKNSLYLMPILPVPSSSWEDGKGKQPKEDRPEHYPGLGKKEEGEEEKGEEEEEELEEEEEEEEETEEEELGKEEIEEKEEERDEKEEKVSWAGIGPTPQPESQESMQWQWQQQLNVMVKEEQEQDEKEAIRRLPAFANLQEALLENMIQNILVEASRGEVVLTSRPRVIALPPFCVPRSLTPDTLLPTQQAEVLHPVVPLPTDLP
Protein: Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled chemoattractant-like receptor) (G-protein coupled receptor DEZ) (O35786)
Organism: Rattus norvegicus (Rat)
Function: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q99788}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Retinoic acid receptor responder protein 2
Sequence:
MEYEGYNDSSIYGEEYSDGSDYIVDLEEAGPLEAKVAEVFLVVIYSLVCFLGILGNGLVIVIATFKMKKTVNTVWFVNLAVADFLFNIFLPIHITYAAMDYHWVFGKAMCKISSFLLSHNMYTSVFLLTVISFDRCISVLLPVWSQNHRSVRLAYMTCVVVWVLAFFLSSPSLVFRDTVSTSHGKITCFNNFSLAAPEPFSHSTHPRTDPVGYSRHVAVTVTRFLCGFLIPVFIITACYLTIVFKLQRNRLAKTKKPFKIIITIIITFFLCWCPYHTLYLLELHHTAVPASVFSLGLPLATAVAIANSCMNPILYVFMGHDFKKFKVALFSRLVNALSEDTGPSSYPSHRSFTKMSSLIEKASVNEKETSTL