wanglab/gogpt-training-data huggingface dataset:
Protein: Bis(monoacylglycero)phosphate synthase CLN5 (BMP synthase CLN5) (EC 2.3.1.-) (Ceroid-lipofuscinosis neuronal protein 5) (Protein CLN5) (Palmitoyl protein thioesterase CLN5) (EC 3.1.2.22) (S-depalmitoylase CLN5) [Cleaved into: Bis(monoacylglycero)phosphate synthase CLN5, secreted form] (Q3UMW8)
Organism: Mus musculus (Mouse)
Function: Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.
Subcellular location: [Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Lysosome {ECO:0000269|PubMed:20052765}.; SUBCELLULAR LOCATION: [Bis(monoacylglycero)phosphate synthase CLN5]: Membrane {ECO:0000250|UniProtKB:O75503}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O75503}. Note=An amphipathic anchor region facilitates its association with the membrane. {ECO:0000250|UniProtKB:O75503}.
Interaction partners:
- Battenin
- Ceroid-lipofuscinosis, neuronal 6
- Protein CLN8
- Palmitoyl-protein thioesterase 1
- Major facilitator superfamily domain-containing protein 8
- Tripeptidyl-peptidase 1
Sequence:
MLRGGPCGAHWRPALALALLGLATILGASPTSGQRWPVPYKRFSFRPKTDPYCQAKYTFCPTGSPIPVMKDNDVIEVLRLQAPIWEFKYGDLLGHFKLMHDAVGFRSTLTGKNYTIEWYELFQLGNCTFPHLRPDKSAPFWCNQGAACFFEGIDDKHWKENGTLSVVATISGNTFNKVAEWVKQDNETGIYYETWTVRAGPGQGAQTWFESYDCSNFVLRTYKKLAEFGTEFKKIETNYTKIFLYSGEPIYLGNETSIFGPKGNKTLALAIKKFYGPFRPYLSTKDFLMNFLKIFDTVIIHRQFYLFYNFEYWFLPMKPPFVKITYEETPLPTRHTTFTDL
Protein: Homocysteine inducible ER protein with ubiquitin like domain 1 (A0A8I6B3C5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTQPRRVASARTLALSPPLRRLSPGADWATLGTDLCLSQWTAATESAICGILARGAHKRYPRRGRVSQRHQVSLWGRRRLRRRPFGIPERSRASSAADMEPEPQPEPVTLLVKSPNQRHRDLELSGDRGWSVSRLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLQDLLPKQEKRHVLHLVCNVRSPSKKPEASTKGAESTEQPDNTSQAQYPGDSSSDGLREREVLRNLPPSGWENVSRPEAVQQTFQGLGPGFSGYTTYGWLQLSWFQQIYARQYYMQYLAATAASGAFGPTPSAQEIPVVSTPAPAPIHNQFPAENQPANQNAAAQAVVNPGANQNLRMNAQGGPLVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRQRPVQNFPDDGPPQEAANQDPNNNLQGGLDPEMEDPNRLPVGREVLDPEHTSPSFMSTAWLVFKTFFASLLPEGPPALAN
Protein: Inactive ADP-ribosyltransferase arh2 (ADP-ribosylhydrolase-like protein 1) ([Protein ADP-ribosylarginine] hydrolase-like protein 1) (Q6AZR2)
Organism: Xenopus laevis (African clawed frog)
Function: Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart. Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (By similarity).
Subcellular location: Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:27217161}.
Interaction partners:
Sequence:
MEKFKAAMLLAGTGDALGYKNFSWVFCASGVKIQEELKQLGGLENLVLSIDGWPVSNNTLMHIATAESLVSDYWSIEDLYRDMVKRYIDVVDKLQGRRPDPATIEGCAHLKPDNYLLAWHTPFNEKGSGFGAATKAMCIGMRYWKPGRLETLIEVSIESGRMTHNHPTGFLGSLCTALFTSYAIQEKPLAQWGREMLKLLPMAEEYCKKTIRHMAEYQEHWFYFEAKWQFYLEEREIAEENENKPKFPDKYDAEERDKAYKTWSSEGRGGRRGHDAPMIAYDALLGAGGDWKELCNRAMFHGGEGGATGSIAGCLYGLLYGISKVPKSLYQQLEMKERLENLGEKLYHLATMEK
Protein: Protein kinase, putative (EC 2.7.1.-) (Q583M3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- GP-PDE domain-containing protein
- Cyclin-dependent kinases regulatory subunit
- Serine/threonine-protein kinase, putative
- Zinc finger protein, putative
- Protein kinase, putative
Sequence:
MDSPTEFSCGTQWDDDRRGEEPLLPELTLHGCGLRNLSLIVRGAQGAVYSAHDENGNRFAVKRLFTQRSDFGIRGVSEGALREATLLTLVRQEMEKLVHDTAFDVVRLQGVVEAPYKELCLILEYCSLDLSQVVVKSKRHTRSFPLVAEGPQVRCPVLSNMGVVRYLLRGILQILNNLHVNCRIIHRDVKLSNFLVRGDGSVRLSDFGSARLLHETVEEKEAAECVTSDPQDEDEVDCSDPFSHSCEGYTPAAQRTTLIYQAPECLLGERTYTTAVDVWAVGIVFAEILLQRHLFRSVNELTLISDIWRLLGTPSTKGEDPNIQGTNGVTFAAPTEPTVDVKFNDDIVSPEGRDLLKKMLEVDPKKRVTAADALRHSFLTSVDAQLSLKEAPALWREKVKECLEGGTQAVPMGAPFLALDDDEEEEEEEEDVDMNMATL
Protein: NudC-like protein (B0FTY2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEPGAAELYDQALLGILQHVGNVQDFLRVLFGFLYRKTDFYRLLRHPSDRMGFPPGAAQALVLQVFKTFDHMARQDDEKRRQELEEKIRRKEEEEAKTVSAAAAEKEPVPVPVQEIEIDSTTELDGHQEVEKVQPPGPVKEMAHGSQEAEAPGAVAGAAEVPREPPILPRIQEQFQKNPDSYNGAVRENYTWSQDYTDLEVRVPLPKHVVKGKQVSVALSSSSIRVAMLEENGECVLMEGKLTHKINTESSLWSLEPGKCVLVNLSKVGEYWWNAILEGEEPIDIDKINKERSMATVDEEEQAVLDRLTFDYHQKLQGKPQSHELKVHEMLKKGWDAEGSPFRGQRFDPAMFNISPGAVQF
Protein: adenylate cyclase (EC 4.6.1.1) (M9PG27)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDDDKLVSDEVHLRQLSATPSSAFSLQHSRGSDTKEEAPPEGGTMGGKSAAPREEGEPDERVVLRRAVDKGAIALAQIDDLKLEGDDDDEAVVNGEEVDGLGLSNPAAQTTDDEQITVNGTGAAATSSVAADAASSEQDAASTAMATPDMSKIPRLPGDGAQMEDNGSGDLPPSLRASTTSILSNLRKKQQGGPLRGGVAKQTPLRVQSVRIVEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIPGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSRLGMPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYLSDEHTDELYSKMHNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISPVRMPAGIPLAQTPNLQRQTSHHGSFSAVVFGMLQASKRSTAIAGTPTGTPSPQIRRGHRGSTFSSVRLSQKSTTVNPVRRNTTRVRGRSYRQKKSSSNNSIVTQASSSYMPSFRRIDQIETTISKSHNDAL
Protein: Probable Rho-type GTPase-activating protein 3 (O14014)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTPase-activating protein for Rho-type proteins.
Subcellular location: Cell tip {ECO:0000269|PubMed:10759889}. Note=Cell poles and division site. {ECO:0000269|PubMed:10759889}.
Interaction partners:
- Cell division control protein 42 homolog
- Probable Rho-GTPase-activating protein 6
- GTP-binding protein rho2
- GTP-binding protein rho1
- GTP-binding protein rho5
- GTP-binding protein rho3
- GTP-binding protein rho4
- Serine/threonine-protein kinase shk1/pak1
- Ras-like protein 1
- Rho guanine nucleotide exchange factor gef1
Sequence:
MIFRKSISKSPSSKGSTVCFRCGQAFQRRETPISFGGHMWHKDCFCCTKCDKGLEHSDQMLVQTSDGRPVCSSCAHTCTACRMRIKDYALMSGYDSYHRECFRCHDCRKQIIDSNFKRDNRTIFCNDCKQVRHPSRSSDESADYHNFEVDVTIKPTETKSSVESNKSLSIEIMSPQKPPLSPFGGSRDRLVSETPTNMSQAEGGNVPNDGQDSNLASNSADSLLPSAKNRSFSSFTSFESPMKYDDSFFPISPSISPLQKVNKQQQIESPTATFPLSKNTWKNRFHTFHKQSFTPVNDSSSSDSLKPTINEEALDDFAGSASPYKTMSLTDRAEPIVMNGHMRSLHNATSPFRPFSPSYRSSDTHSPRTRSPNVQTHKKTSSQPSDLSSFAQLLSPPQVLSPKPNGGGHKSFRHSHSLSETSQQTLVPSLGSNGEYHLPTNDHSSTPAQSERDSDVEELREQLENLTALTKKLSERLSSSTFDNSKFIRTEDKDTVRSAKLEICEKFFSFADVTDDPTLKDPKHQDLVAAANAYMAMLRESYGTEINNLLERRNELLDDYNNVQKILNESLEASVHLNTKNLELADLNNNLVKQIQHRVPPENQSNLEHTITTSSKNTTSSINPLTAVSSNSGQSSGRPGPLSPNLNVTTRIDIKGKKGSMHLQPRDVNRKVPFKSMHTKSKSADPVVGNEDRTQCDHVFHVNAIFKPSRCYICSESVWGSELRCFHCSISCHSRCLKRLFAESEHEKTMSETVSENSKWMPEMPTRMPPPGPSPTMFGRSLENQLKIEGSVLPQVIAMCVSCVDAHGLEVEGIYRISGSASQVRVLVDEFENGSIRMEHLTSDLFACTSVLKTYLHRLPEPVIPGTQYEELLEAEKIEKEEEKIERVVEVMKTLHPAHLSVFRFLIAHLGRVCKHAEKNLMNSKNVSTVFAPTLMRDKVNRFDLQHATKKSTALQFMLDNVDKILHNL
Protein: 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) (P80385)
Organism: Rattus norvegicus (Rat)
Function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Interaction partners:
- 5'-AMP-activated protein kinase subunit beta-1
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- WD repeat-containing protein 5
- Retinoblastoma-binding protein 5
- [histone H3]-trimethyl-L-lysine
- 5'-AMP-activated protein kinase subunit beta-2
- Histone-lysine N-methyltransferase
- WD repeat-containing protein 5B
- PAX-interacting protein 1
Sequence:
MESVAAESAPAPENEHSQETPESNSSVYTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLEAIINRLVEAEVHRLVVVDEHDVVKGIVSLSDILQALVLTGGEKKP
Protein: Actin cross-linking protein (DUF569) (At1g69890/T17F3_8) (Q9CAS2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Disease resistance protein
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- IQ domain-containing protein IQM2
- GDSL esterase/lipase At1g29670
- At3g49790
- GATA transcription factor 8
- Transmembrane ascorbate ferrireductase 1
- Transmembrane ascorbate ferrireductase 2
- E3 ubiquitin-protein ligase RDUF2
Sequence:
MDFFNQAKAVRMRNVHDKYLTADEDEETVTQDRNGSDKRARWIVEPVRGSFEVIRLRSCYGNYLTASNERFLLGATGRKVVLSKPARLDSSVEWEPVREGSKMKLKTRYGNLLRANGGLPPWRNSVTHDTSHVLDSFLWDVDVVEILVGTTTPAPAPAPVTTPPPHRRPSYTYSPVSRTSSEKSEEELTVPPPKSEGRPIYYHIADEEGHVEEESAVGYALTFKGNSVEQLTQALQEETSMDDVVVCTRHPSNGKLFPLRLQLPPNSGTMHVILVPSST
Protein: Homeobox protein otx5-A (Orthodenticle homolog 5-A) (Xotx5) (Q9PVM0)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription factor involved in anterior and eye development. Promotes the differentiation of both rod and cone photoreceptors cells in the retina. Together with other retinal homeobox proteins, acts as an effector of a cellular clock which, depending on cell cycle progression, establishes the generation of distinct retinal neuronal cell types. Acts synergistically with nrl to activate the rhodopsin promoter (By similarity). Promotes the formation of anterior regions and represses the formation of posterior structures during development.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9PT61, ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MMSYIKQPHYAVNGLTLAGTGMDLLHSAVGYPTTPRKQRRERTTFTRAQLDILESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQSTGQAKPRPAKKKTSPARETNSEASTNGQYSPPPPGTAVTPSSTAGATVSIWSPASISPIPDPLSIATTPCMQRSAGYPMTYSQAPAYTQSYGGSSSYFTGLDCGSYLSPMHPQLSAPGSTLSPIASSTMGSHLSQSPASLSAQGYGASSLGFTSVDCLDYKDQTASWKLNFNATDCLDYKDQSSWKFQVL
Protein: Acetylcholinesterase (AChE) (EC 3.1.1.7) (P37136)
Organism: Rattus norvegicus (Rat)
Function: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Subcellular location: Synapse. Secreted. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform H]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Interaction partners:
- Glycerophosphocholine phosphodiesterase GPCPD1
- Choline/ethanolamine kinase
- Choline kinase alpha
- Phosphoethanolamine/phosphocholine phosphatase
- Vesicular acetylcholine transporter
- Choline O-acetyltransferase
- Amyloid-beta precursor protein
- Neuronal acetylcholine receptor subunit alpha-2
- Muscle, skeletal receptor tyrosine protein kinase
- Neuronal acetylcholine receptor subunit alpha-7
Sequence:
MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQERCSDL
Protein: Protein SHC1 (Sporulation-specific homolog of CSD4) (P39000)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the activation of chitin synthase III (CHS3) activity during the sporulation process.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15755916}. Cytoplasmic granule membrane {ECO:0000269|PubMed:15755916}; Peripheral membrane protein {ECO:0000269|PubMed:15755916}.
Interaction partners:
- Chitin synthase 3
- Protein OS-9 homolog
- Sporulation-specific protein 1
Sequence:
MSMTICSNTPGAYPEIGAYNEVDKQLESSGFSSDSSLILNKPEVRQYWSSVSSHISRSGDVFTNDKEKISSSIGEDAMDIDASPSLIEKYNSFPTRKILPEQDEFENDVEDDASSSLKEKSQGSCEIEIASEISSEILNGTSADGNSEFHDFAEPPPSQNESVALSFSQSNDLDFLNNPSGSGSSNDINRSTSSISLPRHVSLDFNVYNSLCLTNEVTASESHNVAKFHLGKKNKKSLLPRWKTIEMYGEVVKKTQDIYSNFQYAQYILRVGLDTEKLHELVKELEDESNSFSVDSLKEYLVNDAKVILKKLSAVGYPDAQYLLGDAYSSGVFGKIKNRRAFLLFSAAAKRMHIESVYRTAICYECGLGVTRNAPKAVNFLTFAATKNHPAAMYKLGVYSYHGLMGLPDDILTKMDGYRWLRRATSMASSFVCGAPFELANIYMTGYKDLIISDPDYAMALYEKAAALGHTESARILEDARRSGGFVSRGHPPSAQKYHKTSHEAVAAKKLI
Protein: PADI4 protein (Q53HY9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
SAPEDCTSFSINASPGVVVDIAHGPPAKKKSTGSSTWPLDPGVEVTLRMKVASGSTGDQKVQISYYGPKTPPVKALLYLTGVEISLCADITRTGKVKPTRAVKDQ
Protein: Protein transport protein Sec61 subunit alpha-like 1 (Q90ZM2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity). Plays a role in the pronephric kidney tubule development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P61619}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P61619}.
Interaction partners:
- SEC63 homolog, protein translocation regulator.
- Protein transport protein Sec61 subunit gamma
- Protein transport protein Sec61 subunit beta
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL15m
- Ribosomal protein S3
- 40S ribosomal protein S15
- Small ribosomal subunit protein uS13
Sequence:
MAIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPSEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGTEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSTRFSGNFLVNLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLDDPVHAVIYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGGLSVMADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
Protein: Myocardin related transcription factor A (B0QY83)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDFSSVVCLPPSVIAVNGLDGGGAGENDDEPVLVSLSAAPSPQSEAVANELQELSLQPELTLGLHPGRNPNLPPLSERKNVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEALGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVVAFPAARLSTGPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRMLRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAPAPSAQMDLEHPLQPLFGTPTSLLKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILIQSGEISADFKEPPSLPGKEKPSPKTVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGRLEDFLESSTGLPLLTSGHDGPEPLSLIDDLHSQMLSSTAILDHPPSPMDTSELHFVPEPSSTMGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL
Protein: Protein FERTILITY RESTORER RF2, mitochondrial (F1SZ42)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Restores fertility in rice varieties with LD-type cytoplasmic male sterility (CMS). CMS is caused by genetic incompatibility between nuclei and mitochondria within male reproductive organs. Corresponds to the functional allele of RF2, which is dependent of the presence of Ile-78 in the japonica cultivars Fukuyama and Owarihatamochi (AC F1SZ42), and indica cultivar Kasalath (AC F1SZ41). Non-functional RF2 alleles are found in japonica cultivars Taichung 65 and Nipponbare (AC F1SZ44), where Ile-78 is replaced by Thr-78.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21265890}.
Interaction partners:
Sequence:
MSTLVTCSLPGAVTTHASTRRFGGSQFQTSQASCISFKREVSAKAVLRSVRCNATQTQSAQRKSSTATVKRSDPKGKIQGPKLDDGSGGFPPFRFGKGGGGGGGGGGGSNYFGGFLLFTCVLLLDYLKEFEKNLIARRQRAGYDANNDMFQQ
Protein: Membrane magnesium transporter (ER membrane protein complex subunit 5 homolog) (Q2HIM5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates Mg(2+) transport.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N4V1}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8K273}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q8K273}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 7 homolog
- ER membrane protein complex subunit-like protein
- ER membrane protein complex subunit 8/9 homolog
Sequence:
MNLGFLVGVFGVLILSHAAYSTIQYRGLLKIMEEEFSRPPINVILELIIGLALCMWAALTFPGKFLSIHPDSDENRAVFLPDNSDFMIFNHRGRLFPPQIDMKF
Protein: Beta-glucosidase 12 (Os4bglu12) (EC 3.2.1.21) (Q7XKV4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydrolyzes p-nitrophenyl beta-D-glucoside, p-nitrophenyl beta-D-galactoside, p-nitrophenyl beta-D-xyloside, p-nitrophenyl beta-D-fucoside, p-nitrophenyl beta-L-arabinoside, cello-oligosaccharides and laminaribiose.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Os01g0542000 protein.
Sequence:
MAAAGAMPGGLLLTFLLLAVVASGAYNGAGEPPVSRRSFPKGFIFGTASSSYQYEGGAAEGGRGPSIWDTFTHQHPEKIADRSNGDVASDSYHLYKEDVRLMKDMGMDAYRFSISWTRILPNGSLRGGVNKEGIKYYNNLINELLSKGVQPFITLFHWDSPQALEDKYNGFLSPNIINDFKDYAEICFKEFGDRVKNWITFNEPWTFCSNGYATGLFAPGRCSPWEKGNCSVGDSGREPYTACHHQLLAHAETVRLYKAKYQALQKGKIGITLVSHWFVPFSRSKSNDDAAKRAIDFMFGWFMDPLIRGDYPLSMRGLVGNRLPQFTKEQSKLVKGAFDFIGLNYYTANYADNLPPSNGLNNSYTTDSRANLTGVRNGIPIGPQAASPWLYVYPQGFRDLLLYVKENYGNPTVYITENGVDEFNNKTLPLQEALKDDARIEYYHKHLLSLLSAIRDGANVKGYFAWSLLDNFEWSNGYTVRFGINFVDYNDGRKRYPKNSAHWFKKFLLK
Protein: DNA damage checkpoint effector kinase (Eurofung) (Q5B1T6)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- non-specific serine/threonine protein kinase
- M-phase inducer phosphatase
- DNA replication licensing factor MCM4
- Protein phosphatase PP2A regulatory subunit B
- DNA replication initiation factor Cdc45
- DNA repair protein RAD51 homolog
- Protein kinase domain-containing protein
- Cell division control protein
- DNA replication protein, putative
- BRCT domain protein
Sequence:
MHHSQLAPLPIDLPFRIVSKTFGQGAYACLKKACPLNADTPVFAVKFINKDYAARHGKISPRQLLMEATVHKHIGDHNNIISFFQTGEDGAWRWIAMELADGGDLFDKIEADEGVSEDIGHVYFTQLISAVGYMHSKGVGHRDIKPENILLTADGNLKIADFGLATLFEYKGGTKLSTTFCGSPPYIAPEVITCSSRNQTKGPGYRPDVADIWSCGIVLFVLLAGNTPWDSPTEDSYEFHEYVMTNARTSDELWQKLPTATLSLLRGMLNIDAQARFSLEDVRRHPWFTRQNKHLAPDGRLRDPIKVATSMFESLHIDLSQSVSRPLKGGSFGPDRMDVDIGDDLGAEHRISSTQPEVPRGDMLIDWDTPHLTDVFSSSQPTNNPRPPSSSLTPEILEDEPSFSQFSQRPSVPMSRTQNAQRFHDIVPSRSLTRFFSTWELKLLVPLICEALHRLGVPVPAVPAVSPGDNSAMIRVITRDGRMCPLHGKVLVECVSEGLFEIEFMKGKGDPLEWRRFFKKVVLLCKDAVYTPDS
Protein: Rho guanine nucleotide exchange factor 10 (O15013)
Organism: Homo sapiens (Human)
Function: May play a role in developmental myelination of peripheral nerves.
Interaction partners:
- Transforming protein RhoA
Sequence:
MRPPGFLSRAPSLNRAERGIWSCSMDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADRQAPSAPETGGAGASEAPAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVIDITPFQEDQPPTPVPSAEEENVGLHVPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATSLDEEAETPEVTEDRQPNSLSSEEPPTSEDQVGREDSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDEGGNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDLMASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDHRSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWIGSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGAPPDPETPAVRASDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVASYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVTSLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKDKDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSSGSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHRKARQPHQEELAPTVMVWQIPLLNI