wanglab/gogpt-training-data huggingface dataset:
Protein: Nucleoside diphosphate kinase (NDK) (NDKA) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) (P9WJH7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00451}.
Interaction partners:
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein bS6
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein uS5
Sequence:
MTERTLVLIKPDGIERQLIGEIISRIERKGLTIAALQLRTVSAELASQHYAEHEGKPFFGSLLEFITSGPVVAAIVEGTRAIAAVRQLAGGTDPVQAAAPGTIRGDFALETQFNLVHGSDSAESAQREIALWFPGA
Protein: WT1 transcription factor (A0A1W2PR07)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MRDQVLPQAVEGGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
Protein: Protein AUXIN-REGULATED GENE INVOLVED IN ORGAN SIZE (BrARGOS) (C7SFP6)
Organism: Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis)
Function: Promotes cell proliferation-dependent organ growth.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q6NMD6}; Multi-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000250|UniProtKB:Q6NMD6}. Cytoplasm {ECO:0000250|UniProtKB:Q6NMD6}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6NMD6}.
Interaction partners:
- methionine--tRNA ligase
- methionine--tRNA ligase
Sequence:
MIRKTPNLQNDIINIQERYSNNLVMDVGGGRNSRKNVNFRRPPPAMTSENSKHELRRTFSSQKRLMIPANYFSLESLVILVGLTASLLILPLVLPPLPPPPFMLLLVPIGIMVLLIILAFMPSSSSRAKDVTRTFM
Protein: Proteasome regulatory ATPase subunit 6 (EC 3.6.4.8) (Q38A02)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 26S proteasome regulatory subunit RPN3
- Proteasome regulatory non-ATP-ase subunit 9
- Proteasome subunit alpha type
- Proteasome regulatory ATPase subunit 1
- Proteasome regulatory non-ATP-ase subunit 7
- Proteasome subunit beta
- Uncharacterized protein
- Proteasome regulatory non-ATP-ase subunit 2
- Protease regulatory ATPase subunit 4
- Proteasome subunit alpha type
Sequence:
MATKMVTPTATASDTDNPVSTYFLQKIQELRAQEKRLQDNYMRLEAQRNELNRRVRHLKEEVQLLQESGSIVADVVRVMSKGKVLVNVSSSQGKLVVDVEKTVNIDDLSRNVRVALRSGTFAIHYILPTKVDPLVSLMKVENAGSESTYDEIGGLSRQVKEIKEVIELSVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGAELVQKYIGEGARLVRELFVMAREHSPSIIFMDEIDSIGSTRLENTGRGGDSEVQRTMLELLNQLDGFESTQSIKVIMATNRVDILDEALLRPGRIDRKIEFPAPDEPARFEILKIHSRKMNLTRGINLRTVAEKTNQCSGAELKAVCTEAGMFALRERRVHITQEDFELAVAKIMHKDQDKSVSLKKMWK
Protein: Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (UFM1-activating enzyme) (Q8VE47)
Organism: Mus musculus (Mouse)
Function: E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (By similarity). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (By similarity). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (By similarity). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (By similarity). Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9GZZ9}. Nucleus {ECO:0000250|UniProtKB:Q9GZZ9}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9GZZ9}. Golgi apparatus {ECO:0000250|UniProtKB:Q9GZZ9}. Note=Localizes mainly in the cytoplasm, while it localizes to the nucleus in presence of SUMO2. Interaction with GABARAPL2 promotes localization to the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q9GZZ9}.
Interaction partners:
- Ubiquitin-fold modifier 1
- Ubiquitin-fold modifier-conjugating enzyme 1
- Ufm1-specific protease 2
- E3 UFM1-protein ligase 1
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Ufm1-specific protease 1
- DDRGK domain-containing protein 1
- NEDD8-conjugating enzyme Ubc12
- NEDD8-conjugating enzyme UBE2F
- Ubiquitin-like modifier-activating enzyme 7
Sequence:
MADSVERLRQRVEELEQELARERTRRSGGDGHCGRTRIQEMSDEVLDSNPYSRLMALKRMGIVSDYKKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPYQAGLSKVHAAEHTLRNINPDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMIPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGTVSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAAALPTQEAEPQEEAEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKTEDSASEVTVEDSGESLEDLMARMKNM
Protein: Error-prone DNA polymerase 2 (EC 2.7.7.7) (Q92ZJ6)
Organism: Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Function: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
Interaction partners:
Sequence:
MRYAELQVTTHFSFLRAASSAEELFATARLMGIEALGVVDRNSLAGIVRALEASRATGLRLVVGCRLDLQDGMSILVYPTDRAAYSRLTRLLTLGKGRGGKANCIIHFDDVALYAEGLIGILVPDLADEVCAVQLRKIAEVFGDRAYVSLCLRRRPNDQLQLHELTNLAVKHRVKTIVTNDVLFHEHGRRQLQDVVTCIRTGMTIDDVGFERERHADRYLKPPEEMARLFPAYPEALARTMEIVERCRFSLEELVYQYPEEALILGMTAQQSLQHYTWEGVRARYPEGLPTHVEKTIRHELALIETMKYAPYFLTVFSIVRYARSQGILCQGRGSAANSAVCYVLGITSIDPETNDLLFERFVSQERDEPPDIDVDFEHERREEVIQWIYKTYGHDKAALCSTVTRYRAKGAIRDVGKALDLPEDLIRTLSSGIWSWSETVGERQVRELGLNPDDRRLTLTLRLAQQLMGAPRNLSQHPGGFVLTHDRLDDLVPIEPATMADRQVIEWDKDDIEALKFLKVDVLALGMLTCMAKAFALISEHKHEDIDLATIPQEDPATYAMIRKADTLGTFQIESRAQMSMLPRMKPRTFYDLVIQVAIVRPGPIQGDMVHPYLRRREGKEKVEYPTPELEAVLHKTLGVPLFQESAMRVAMVCAGFTGGEADQLRKSMATFKFTGGVSRFKDKLVNGMIRNGYTKEFAEKTFSQLEGFGSYGFPESHAASFALIAYASNYIKCYFPDVFCAALLNSQPMGFYAPAQIVRDAREHGVEVRPICINRSRWDCMLEPIDGSGGHAVRLGMRLVRGLATADAARIVAARADEPFTSVDDMWRRSGVPVASLVELAEADAFLPSLSLERRDALWAIKALRDEPLPLFTAAADREARAIAEQEEPEVELRQMTDGQNVVEDYSHTGLTLREHPLRFMRDDLAKRRIVTCAQAMTAHDGQWLMAAGLVLVRQRPGSAKGVMFITIEDETGIANIVVWPKLFERSRRVVLGASMMAINGRIQREGEVVHLVAQQLFDLSADLSSLAERDGAFRPPTGRGDEFAHGSPGSADSRGKAPPGVRARDILVPDLHIDTLKIKSRNFQ
Protein: NAC domain-containing protein 53 (ANAC053) (Protein ANTHER INDEHISCENCE FACTOR) (Protein NTM1-like 4) (Q949N0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Promotes reactive oxygen species (ROS) production during drought-induced leaf senescence. In response to abscisic acid (ABA)-mediated drought stress signals, binds directly to the promoters of RBOHC and RBOHE genes, encoding ROS biosynthetic enzymes, resulting in ROS accumulation and triggering leaf senescence via programmed cell death (PCD). ROS-induced leaf senescence sustains plant survival under drought conditions. Involved in heat stress response. Modulates PCD through a ROS-mediated positive feedback control under heat stress conditions. This may provide an adaptation strategy for plant survival under extreme heat stress conditions. Acts as repressor in preventing anther dehiscence during stamen development by suppressing genes that participate in jasmonic acid (JA) biosynthesis, such as DAD1, AOS, AOC3, OPR3 and 4CLL5/OPCL1.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24323506}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:24323506, ECO:0000269|PubMed:25219309, ECO:0000269|Ref.6}. Note=Localized primarily in plasma membrane or endoplasmic reticulum membrane as dormant form and, upon abiotic stress, is processed into a transcriptionally active and nuclear form after a proteolytic cleavage through regulated intramembrane proteolysis (RIP). {ECO:0000269|PubMed:24323506, ECO:0000269|PubMed:25219309, ECO:0000269|Ref.6}.
Interaction partners:
Sequence:
MGRGSVTSLAPGFRFHPTDEELVRYYLKRKICNKPFKFDAISVTDVYKSEPWDLPDKSRLKSRDLEWYFFSMLDKKYRNGSKTNRATEMGYWKTTGKDREILNGSKVVGMKKTLVYHKGRAPRGERTNWVMHEYRLVDQDLDKTGVHQDAFVLCRIFQKSGSGPKNGEQYGAPFVEEEWEEEDDMTFVPDQEDLGSEDHVYVHMDDIDQKSENFVVYDAIPIPLNFIHGESSNNVETNYSDSINYIQQTGNYMDSGGYFEQPAESYEKDQKPIIRDRDGSLQNEGIGCGVQDKHSETLQSSDNIFGTDTSCYNDFPVESNYLIGEAFLDPNSNLLENDGLYLETNDLSSTQQDGFDFEDYLTFFDETFDPSQLMGNEDVFFDQEELFQEVETKELEKEETSRSKHVVEEKEKDEASCSKQVDADATEFEPDYKYPLLKKASHMLGAIPAPLANASEFPTKDAAIRLHAAQSSGSVHVTAGMITISDSNMGWSYGKNENLDLILSLGLVQGNTAPEKSGNSSAWAMLIFMCFWVLLLSVSFKVSILVSSR
Protein: Putative acyl-coenzyme A oxidase At3g06690 (Acyl-CoA oxidase) (EC 1.3.3.6) (P0CZ24)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 3-ketoacyl-CoA thiolase 5, peroxisomal
- 3-ketoacyl-CoA thiolase 1, peroxisomal
- 3-ketoacyl-CoA thiolase 2, peroxisomal
- Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2
- Peroxisomal fatty acid beta-oxidation multifunctional protein AIM1
- Probable enoyl-CoA hydratase 1, peroxisomal
- Probable acyl-CoA dehydrogenase IBR3
- Acetyl-CoA acetyltransferase 1
- Acetyl-CoA acetyltransferase 2
- Putative peroxisomal acyl-coenzyme A oxidase 1.2
Sequence:
MTKEPIYSPRMLHRDPDSPRPVLPTQLTSSTLRCSQFQTNVFCLRERDLLERFTSEVAQLQGRGESREFSFLLSHQLAEDLGKAFTEKAMLQTILDAEAKLPTGSVKDVLGLVRSMYALISLEEDPSLLRYGYLSQDNVGDVRREVSKLCGELRPHALALVTSFGIPDSFLSPIAFNWVEANTWSSV
Protein: Serpin family H member 1 (E9PR70)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMG
Protein: Capsid protein (Coat protein) (P03607)
Organism: Southern cowpea mosaic virus (SCPMV) (Southern bean mosaic virus (strain cowpea))
Subcellular location: Virion {ECO:0000305}.
Interaction partners:
Sequence:
MSGLFHHRTKPREIRAFVMATRLTKKQLAQAIQNTLPNPPRRKRRAKRRAAQVPKPTQAGVSMAPIAQGTMVKLRPPMLRSSMDVTILSHCELSTELAVTVTIVVTSELVMPFTVGTWLRGVAQNWSKYAWVAIRYTYLPSCPTTTSGAIHMGFQYDMADTLPVSVNQLSNLKGYVTGPVWEGQSGLCFVNNTKCPDTSRAITIALDTNEVSEKRYPFKTATDYATAVGVNANIGNILVPARLVTAMEGGSSKTAVNTGRLYASYTIRLIEPIAAALNL
Protein: Small ribosomal subunit protein uS19c (30S ribosomal protein S19, chloroplastic) (Q6EN80)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Small ribosomal subunit protein uS14c
- Small ribosomal subunit protein uS12c
- Large ribosomal subunit protein uL2cz/uL2cy
- 30S ribosomal protein S13
- Uncharacterized protein
- Small ribosomal subunit protein uS8c
- Large ribosomal subunit protein uL16c
- Small ribosomal subunit protein bS16c
- 50S ribosomal protein L16
- Large ribosomal subunit protein uL5c
Sequence:
MTRKKTNPFVAHHLLAKIEKVNMKEEKETIVTWSRASSILPAMVGHTIAIHNGKEHIPIYITNPMVGRKLGEFVPTRHFTSYESARKDTKSRR
Protein: (+)-borneol dehydrogenase 2 (SoBDH2) (EC 1.1.1.198) (A0A8F5XX49)
Organism: Salvia officinalis (Sage)
Function: Involved in the biosynthesis of monoterpene natural products related to camphor. Catalayzes the oxidation of (+)-borneol to (+)-camphor. Shows absolute selectivity towards (+)-borneol. Catalyzes the oxidation of (+)-isoborneol to (-)-camphor. Shows absolute selectivity towards (+)-isoborneol.
Interaction partners:
Sequence:
MATGAANVESPQSLPLRLLGRVALVTGGSSGIGESIVLLFRKHGAKVCIADVQDNQGQRLCETLGGSSDIAFCHCDVTIEDDVKRAVDFTVDKFGTLDIMVNNAGVSGPPCPDIRDFELSAFDRVFDINVRGVFIGMKHAARIMIPAKKGSIISISSVASTMGGLGPHAYTGSKHAVLGLTKNVAAELGKHGIRVNCVSPYAVATSLALAHLPEAERTEDTWDDFRRFVADNANLQGVELTMEDVANAVVFLASDEARYVSGMNLMVDGGFTSTNHALQVFRP
Protein: Ras GTPase-activating protein 2 (GTPase-activating protein 1m) (GAP1m) (Q15283)
Organism: Homo sapiens (Human)
Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region.
Interaction partners:
- Ras-related protein R-Ras
- GTPase NRas
- GTPase HRas
- GTPase KRas
- Ras-related protein M-Ras
- Ras-related protein R-Ras2
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein G
- Ras GTPase-activating protein 1
Sequence:
MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS
Protein: KxDL motif-containing protein 1 (Q80XH1)
Organism: Mus musculus (Mouse)
Function: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). May also be involved in the biogenesis of lysosome-related organelles such as melanosomes.
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q9BQD3}.
Interaction partners:
- BLOC-1-related complex subunit 8
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- SNARE-associated protein Snapin
- BLOC-1-related complex subunit 7
- BLOC-1-related complex subunit 5
- BLOC-1-related complex subunit 6
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- E3 ubiquitin-protein ligase RNF4
Sequence:
MDTPDSASRVFCGRFLSMVNTDDVNAIILAQKNMLDRFEKTNEMLLNFNNLSSVRLQQMSERFMHHTRTLVDMKRDLDSIFRRIRTLKGKLARQHPEAFSHIPEGSFLEDEDEDPIPPSITTTIATSEQSTGSCDTSPDTVSPSLSPGFEDLSHIQPGSPAINGHRQTDDEEETHEE
Protein: TNF Receptor Associated Factor (TRAF) homolog (TRF-1) (G5EG80)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Death domain-containing protein
- TIR domain-containing protein
- Pelle-like serine/threonine-protein kinase pik-1
- Ras-related protein Rap-1
- Ubiquitin-ribosomal protein eL40 fusion protein
- VWFA domain-containing protein
- Protein kinase domain-containing protein
- EGF-like domain-containing protein
- Tyrosine-protein phosphatase 4
- Double-strand telomeric DNA-binding proteins 2
Sequence:
MTSQSVMFKGGLPADCTCPICEQALRDPIKLNCDHHYCRQCFENENRTPGCAACQTIIQPELCQHDRAKQKQILALPVVCTFESSGCPWDGQLGTLHDHLSECTFKSSLKCEKCGRQFAKNDLEKHRAKCELNRAVCSFCNKTIRDSDRERHPKTCPQVIISCPFQCGLTDRPRLEIEAHCPSCPNVDNVCPFVPYGCTFAGGKESIQQHLSDEPVRHLMYLCDEITDLKGTYELMERDMGSFNDRQTRILSAAETCTEMFGPQLIWKIDKLQQRTNEAKSGADTTIFSVPFMSHRFGYKMMACACLFGDGSSAGKSISLYVLLLKGEFDPTLEWPFHRAIKISLLDQNPRPEDRVNITYVIDPRKLKANEKFLARPRGERNAAFGSQSFCSLAILQNYVKDDKIYVQIDVDRCETLPVQLKSRDAKERKQMLDAMRAKTPDVRLHQVRPVTSQSSSAELRV
Protein: N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Karyogamy protein 4) (Methyltransferase-like protein 14) (dMettl14) (Q9VLP7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Non-catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the heterodimer formed with Ime4/Mettl3, Mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions.
Subcellular location: Nucleus {ECO:0000269|PubMed:27919077, ECO:0000269|PubMed:28675155}.
Interaction partners:
- Pre-mRNA-splicing regulator female-lethal
- E3 ubiquitin-protein ligase Hakai
- N
- Protein virilizer
- Fl
- RNA-binding protein spenito
- YTH domain-containing protein 1
- LD23072p
- YTH domain-containing family protein
- IP18003p
Sequence:
MSDVLKSSQERSRKRRLLLAQTLGLSSVDDLKKALGNAEDINSSRQLNSGGQREEEDGGASSSKKTPNEIIYRDSSTFLKGTQSSNPHNDYCQHFVDTGQRPQNFIRDVGLADRFEEYPKLRELIKLKDKLIQDTASAPMYLKADLKSLDVKTLGAKFDVILIEPPLEEYARAAPSVATVGGAPRVFWNWDDILNLDVGEIAAHRSFVFLWCGSSEGLDMGRNCLKKWGFRRCEDICWIRTNINKPGHSKQLEPKAVFQRTKEHCLMGIKGTVRRSTDGDFIHANVDIDLIISEEEEFGSFEKPIEIFHIIEHFCLGRRRLHLFGRDSSIRPGWLTVGPELTNSNFNSELYQTYFAEAPATGCTSRIELLRPKSPPPNSKVLRGRGRGFPRGRGRPR
Protein: RH32892p (Uncharacterized protein, isoform D) (Q8IGF3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDSTLNIENVNDPTSIASDLSAENTKADLVSLNEPNVNDQTSSASDLTAENTKADHDSLNKPKDFNNQILNIISDIDINIKAQEKITQLKEQELKLIQKQNDLANEIHKQQILAKQLSAQNQLKQNECQSGELDLHSQYQNERGGPTSTLYQEKNIASKESANVSKTVDLRKIFTPATDAAEILPKNRKLYASSAFYSPTLHPTVEDQVELARRISHSLSDISNQTSKGQSMYVNRKKRSDKWVHEGGSQGNVFFQYFLLSVSY
Protein: Protein kinase byr1 (EC 2.7.12.2) (MAPK kinase) (MAPKK) (P10506)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11683500}. Note=Localizes to the cell tips and septum forming regions.
Interaction partners:
- Protein kinase byr2
- Mitogen-activated protein kinase spk1
- Ras-like protein 1
- Protein kinase wis1
- Guanine nucleotide-binding protein alpha-1 subunit
- Mitogen-activated protein kinase sty1
- MAP kinase kinase kinase mkh1
- Pheromone M-factor receptor
- MAP kinase kinase skh1/pek1
- Response regulator mcs4
Sequence:
MFKRRRNPKGLVLNPNASVKSSDNDHKEELINNQKSFESNVEAFMEQCAHMNRRPAWISDLDNSSLEVVRHLGEGNGGAVSLVKHRNIFMARKTVYVGSDSKLQKQILRELGVLHHCRSPYIVGFYGAFQYKNNISLCMEYMDCGSLDAILREGGPIPLDILGKIINSMVKGLIYLYNVLHIIHRDLKPSNVVVNSRGEIKLCDFGVSGELVNSVAQTFVGTSTYMSPERIRGGKYTVKSDIWSLGISIIELATQELPWSFSNIDDSIGILDLLHCIVQEEPPRLPSSFPEDLRLFVDACLHKDPTLRASPQQLCAMPYFQQALMINVDLASWASNFRSS
Protein: Glycosyl transferase, group 1 family protein (Q726W1)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Glycosyltransferase-like protein
Sequence:
MRIGICIQWGVEGWTGGINYLRHLVLGAASLPPRLRPRIVLLFEAAQAAALPLYESIVPLADEVRVMHGTRDAAGVYHVHDPETVFAGLDIAYPLPHGFADVPSGLPRLFWIPDFQHRHLPRFFPERELAERDALFSAIGRSADVVVLSSEAARRDVMAFYGVPRERTFVLPFCTVGEEDWYAGDVAAVQARHGIAPGYLMCCNQFWAHKDHLTLFRALARLRAEGGVPQLVCTGGTDDYRDPKHFPMLLRALDRLGIAEQVRILGLIDRRDQIQLLRGADAVVQPSLFEGWSTVVEDARALGKTIVLSDIDVHLEQDPPHGHTFRAGDPADLARALQEAQGDFTPTAGTERETEARADNAERLLRFGMGLVHLARAAQEARPDCVG
Protein: Protein HIRA (TUP1-like enhancer of split protein 1) (P54198)
Organism: Homo sapiens (Human)
Function: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Subcellular location: Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
Interaction partners:
- Calcineurin-binding protein cabin-1
- Histone chaperone ASF1A
- Ubinuclein-1
- Histone chaperone ASF1B
- Histone H3.3
- Ubinuclein-2
- HIRA-interacting protein 3
- Integral membrane protein DGCR2/IDD
- Zinc finger protein 74
- Smoothelin
Sequence:
MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAATREMGSATSVAGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDSMNATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTSMTPTAVERLKEQNLVKELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVETVEKKKKGRPRKDSRLMPVSLSVQSPAALTAEKEAMCLSAPALALKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSRLKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTLHCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQAARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICKDLLGPVHYSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK
Protein: Mitochondrial genome maintenance protein MGM101 (P32787)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA.
Subcellular location: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:10209025, ECO:0000269|PubMed:14576278}.
Interaction partners:
- ATP-dependent DNA helicase MPH1
- Large ribosomal subunit protein mL67
- ARS-binding factor 2
- DNA-directed RNA polymerase, mitochondrial
- DNA mismatch repair protein MSH6
- Single-stranded DNA-binding protein RIM1, mitochondrial
- Mitochondrial distribution and morphology protein 10
Sequence:
MKSIFKVRGCVSHAAQFCQKRTVVSTGTSNTATAGAVRKSFNSTETKPVFATKSEAGNGSHMKEYSSGINSKLGGTPLETRSTADDSLNNSYKQVKGDIDWYTSWYGLGMKPFEAKVQKDLIEPLDPKDIEIKPDGLIYLPEIKYRRILNKAFGAGGWGLVPRSQTIVTSKLVTREYGLICHGQLISVARGEQDYFNEAGIPTATEGCKSNALMRCCKDLGVGSELWDPVFIKKFKVDHCTEKFVEHVTTKRKKKIWLRKDRQVEYPYK
Protein: Ubiquilin-3 (Q9H347)
Organism: Homo sapiens (Human)
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 4
- TAR DNA-binding protein 43
Sequence:
MAKGGEALPQGSPAPVQDPHLIKVTVKTPKDKEDFSVTDTCTIQQLKEEISQRFKAHPDQLVLIFAGKILKDPDSLAQCGVRDGLTVHLVIKRQHRAMGNECPAASVPTQGPSPGSLPQPSSIYPADGPPAFSLGLLTGLSRLGLAYRGFPDQPSSLMRQHVSVPEFVTQLIDDPFIPGLLSNTGLVRQLVLDNPHMQQLIQHNPEIGHILNNPEIMRQTLEFLRNPAMMQEMIRSQDRVLSNLESIPGGYNVLCTMYTDIMDPMLNAVQEQFGGNPFATATTDNATTTTSQPSRMENCDPLPNPWTSTHGGSGSRQGRQDGDQDAPDIRNRFPNFLGIIRLYDYLQQLHENPQSLGTYLQGTASALSQSQEPPPSVNRVPPSSPSSQEPGSGQPLPEESVAIKGRSSCPAFLRYPTENSTGQGGDQDGAGKSSTGHSTNLPDLVSGLGDSANRVPFAPLSFSPTAAIPGIPEPPWLPSPAYPRSLRPDGMNPAPQLQDEIQPQLPLLMHLQAAMANPRALQALRQIEQGLQVLATEAPRLLLWFMPCLAGTGSVAGGIESREDPLMSEDPLPNPPPEVFPALDSAELGFLSPPFLHMLQDLVSTNPQQLQPEAHFQVQLEQLRSMGFLNREANLQALIATGGDVDAAVEKLRQS