wanglab/gogpt-training-data huggingface dataset:
Protein: ISWI chromatin-remodeling complex ATPase ISW2 (EC 3.6.4.-) (Q5A310)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
Interaction partners:
- WAC domain-containing protein
- Histone H4
- Histone H2A.Z
- Uncharacterized protein
- ESCRT-I subunit protein
- DNA polymerase epsilon subunit D
Sequence:
MTTTSTTTTNTTNGQFCSDESLEERRKRFLLEVDAKHERAHDKDDATKRFQYLLGLSALFRKFINLNASKDPAFKKRIREIDSKTSFKESSKKAKNSRRRKTEKEEDAELLQDEEHQDDEDHQHTVMTESPSYIKEGKLREYQIQGLNWLISLYENRLSGILADEMGLGKTLQTISFLGYLRYIKHIDGPFIVIVPKSTLDNWRREFAKWTPDVNVVVLQGDKEQRASIIKDQLYTAKFDVLITSFEMILREKSALQKFRWEYIVVDEAHRIKNEDSSLSKIIRLFYSRNRLLITGTPLQNNLHELWALLNFLLPDVFGDSDQFDEAFDNQNSEELDEEEKQRRQDKAVSELHQLLSPFLLRRVKADVEKSLLPKIETNVYIGMTDMQVEWYKRLLEKDIDAVNGVVGKREGKTRLLNIVMQLRKCCNHPYLFDGAEPGPPYTTDEHLVYNSGKMIILDKMLKKFKAEGSRVLIFSQMSRVLDILEDYCYFRDYEYCRIDGSTSHEDRIEAIDEYNAPDSEKFIFLLTTRAGGLGINLTSADIVILYDSDWNPQADLQAMDRAHRIGQKKQVKVFRFVTEKAIEEKVLERAAQKLRLDQLVIQQGRQMNSNNNVGNSKDDLIGMIQHGAKEVFENSKGTMLDDDVEEILKRGAEKTAELNNKFNKLGLDDIQNFTSDASAYEWNGQDFTKKGNNASLGLNWINPSKRVRKELTYSVDNYYKDVLKQPAVVKEKVVKQPVVKPKAPKSYNVQDHQFFADELVTLLEREQLAFKKEISYQYSVDDFGDSDEEFLEQDDEDDMTRDEKRKIAQEKINNAVALTEEEIATRDRLLEESFHNWSRRDFTNFIHATAKYGRNEYKKIAKALGNKKRSEIERYSKMFWQNYQKIEGYEKYLSQIEAVEKKREKLINQQKLLAKKIESLQDPLEDLKIQYPPNNSKRVYSKTEDKFLLYCVHKYGLSTENLYDKIKDEILTSDIFKFDWYIRSRTPQEIGRRISTLLLAITREMEGPLHGKKRKAMGESNNSSRFGSVEPSSINGEKHSPEVIDNEQTVKKLKL
Protein: Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Rpn13 homolog) (Q9JKV1)
Organism: Mus musculus (Mouse)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (By similarity). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15819879}. Nucleus {ECO:0000250|UniProtKB:Q16186}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
- 26S proteasome regulatory subunit 8
- 26S proteasome regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome non-ATPase regulatory subunit 1
- 26S proteasome non-ATPase regulatory subunit 6
- 26S proteasome non-ATPase regulatory subunit 8
- 26S proteasome regulatory subunit 10B
- Tripartite motif-containing protein 30A
- 26S proteasome non-ATPase regulatory subunit 2
Sequence:
MTTSGALFPSLVPGSRGSSTKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGTVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNECLNNPPMPGSLGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPASSSSSSSRSQSAAVTPSSSTSSARATPAPSAPAAASATSPSPAPSSGNGTSTAASPTQPIQLSDLQSILATMNVPAGPGGSQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKSDPKEGDTKDKKDEEEDMSLD
Protein: Histone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.Bbd) (Histone H2A-like 2) (H2A.L.2) (H2AL2) (Histone H2Alike 2) (Testis-specific expressed gene 1 protein) (TSEG-1) (Q9CQ70)
Organism: Mus musculus (Mouse)
Function: Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells. Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes. In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes. Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction.
Subcellular location: Nucleus {ECO:0000269|PubMed:17261847}. Chromosome {ECO:0000269|PubMed:17261847}. Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). {ECO:0000269|PubMed:17261847}.
Interaction partners:
- Histone H2B type 1-A
- Testis-specific H1 histone
Sequence:
MARKRQRRRRRKVTRSQRAELQFPVSRVDRFLREGNYSRRLSSSAPVFLAGVLEYLTSNILELAGEVAHTTGRKRIAPEHVCRVVQNNEQLHQLFKQGGTSVFEPPEPDDN
Protein: Chromosome partition protein Smc (P51834)
Organism: Bacillus subtilis (strain 168)
Function: Required for chromosome condensation and partitioning.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01894, ECO:0000269|PubMed:9573042}. Note=Probably associated with the nucleoid.
Interaction partners:
- Segregation and condensation protein A
- Signal recognition particle receptor FtsY
- Segregation and condensation protein B
- Sporulation initiation inhibitor protein Soj
- Stage 0 sporulation protein J
- Septum site-determining protein DivIVA
Sequence:
MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAIRWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTRRVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSIFEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEKKKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKIQALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETVLKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHSQVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVKEVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQNSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTVLITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDVTKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQVAEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQKQTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSFLTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMKRLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKRVKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMTKRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNLLSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIVITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ
Protein: Protein GLUTAMINE DUMPER 3 (Protein LESS SUSCEPTIBLE TO BSCTV 1) (Protein LBS1) (Q9FHH5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable subunit of an amino acid transporter involved in the regulation of the amino acid metabolism. Stimulates amino acid export by activating nonselective amino acid facilitators. Acts upstream genes involved in the salicylic acid (SA) pathway and in the geminivirus-host interaction.
Subcellular location: Membrane {ECO:0000269|Ref.7}; Single-pass membrane protein {ECO:0000269|Ref.7}.
Interaction partners:
- Zinc finger CCCH domain-containing protein 26
- Zinc finger CCCH domain-containing protein 57
- UDP-glycosyltransferase 85A4
- Zinc finger CCCH domain-containing protein 33
- Myb-related protein 1
Sequence:
MEGRQYYPPRENVEGNRTTMGGGPHSPWHSPVPYLFGGLAAMLGLIAFALLILACSYWRLSGYLDGEENQSRERDLEVGDVKPDKTAVKPVALPEKFLVIMAGNVKPTYLATPSVKTCTCDDDDDEDDDVEGSDQVVPRSSESNGETH
Protein: Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) (P17301)
Organism: Homo sapiens (Human)
Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Integrin beta-1
- Fibronectin
- Integrin beta-3
- Collagen alpha-1
- Integrin beta-5
- Platelet glycoprotein VI
- Collagen alpha-1
- Integrin beta-2
- Integrin beta-6
- Collagen alpha-2
Sequence:
MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKEGILGQHQFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS
Protein: NADH dehydrogenase-like protein Rv1812c (EC 1.6.-.-) (P9WJJ1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv0572c
Sequence:
MTRVVVIGSGFAGLWAALGAARRLDELAVLAGTVDVMVVSNKPFHDIRVRNYEADLSACRIPLGDVLGPAGVAHVTAEVTAIDADGRRVTTSTGASYSYDRLVLASGSHVVKPALPGLAEFGFDVDTYDGAVRLQQHLQGLAGGPLTSAAATVVVVGAGLTGIETACELPGRLHALFARGDGVTPRVVLIDHNPFVGSDMGLSARPVIEQALLDNGVETRTGVSVAAVSPGGVTLSSGERLAAATVVWCAGMRASRLTEQLPVARDRLGRLQVDDYLRVIGVPAMFAAGDVAAARMDDEHLSVMSCQHGRPMGRYAGCNVINDLFDQPLLALRIPWYVTVLDLGSAGAVYTEGWERKVVSQGAPAKTTKQSINTRRIYPPLNGSRADLLAAAAPRVQPRP
Protein: Peritrophic membrane chitin binding protein (H2L042)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTLTSKYVFQEQTRRRQPSRLLTECPRDGSCRLPSCFCTSTGKIPPNNFDTKQVPQMVMLSFDDPITDRIINTLKSLFSGSIRNPNGCAIKGTFFVSHQWNNYDQSLWLHSTNHEIGVNSITREDLSGRTQERWYKEQKGMRETLAEFSFIDRSHIIGTRAPELKIGGDAQYRMMSENNFTFDNSMLVSSPYWPQTLDHKLAWECDGNCPTQSHKAIWEIPIQNIQANDTRWYKTLTRAMKPFDSRDSVTKMLQRNFMNHYKTNRAPFILTLDTEFLTYLPDNGAVYALRDFLKFIVQKQDVFVVTGSQIIDYMRNPVDLNNIKSLRSWQCKPQMKDEANPCENPTTCSFSGRARGQFAHSFRMCGVCPKSYPWI
Protein: Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh) (O60245)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Gap junction alpha-1 protein
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- GTP-binding protein 2
- GTP-binding protein 1
- Cholecystokinin receptor type A
- Stromal interaction molecule 2
Sequence:
MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQMRLHPYITVFG
Protein: MIP05618p (Synaptotagmin alpha, isoform B) (C0HDP4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTTHSLSAGEMDIVIREEDISLAQIGVYASVSFLVVSAVGAALYTTCSKRYRLNWFEQNLLESANEKDEDQQREALVAGAVGYNVDNVNEVPRGKYSSGNAGNLSPTSLKSEDNDPAFWVPASVTSTAAIQQQVSNTTEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVVLAMHPSRPRVSSMNAKLDHTKIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGGLLNVRLLEAQNLQPRQFSGTADPYAKVRLLPDKKNFWQTRIHKRTLNPVFDEQFVFEVTAGVIDKRTVEILLYDFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPLSSASAQDMKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQRGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIGNSPEVRTEEKIFFEEVFRAKNATAQWVPLQEPANNLATSAKSSKN
Protein: Uncharacterized protein C6orf15 (Protein STG) (Q6UXA7)
Organism: Homo sapiens (Human)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- FACT complex subunit SPT16
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB4
- Transcription elongation factor SPT4
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II subunit RPB3
- Protein IWS1 homolog
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
Sequence:
MQGRVAGSCAPLGLLLVCLHLPGLFARSIGVVEEKVSQNLGTNLPQLGQPSSTGPSNSEHPQPALDPRSNDLARVPLKLSVPASDGFPPAGGSAVQRWPPSWGLPAMDSWPPEDPWQMMAAAAEDRLGEALPEELSYLSSAAALAPGSGPLPGESSPDATGLSPKASLLHQDSESRRLPRSNSLGAGGKILSQRPPWSLIHRVLPDHPWGTLNPSVSWGGGGPGTGWGTRPMPHPEGIWGINNQPPGTSWGNINRYPGGSWGNINRYPGGSWGNINRYPGGSWGNIHLYPGINNPFPPGVLRPPGSSWNIPAGFPNPPSPRLQWG
Protein: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-methylbutyryl-coenzyme A dehydrogenase) (A0A0S2Z3P9)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVGSFCLSEAGAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY
Protein: Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) (P70380)
Organism: Mus musculus (Mouse)
Function: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (By similarity). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (By similarity). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14116}. Secreted {ECO:0000269|PubMed:30392956}. Note=The precursor is cytosolic (By similarity). In response to inflammasome-activating signals, cleaved and secreted (By similarity). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:30392956). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (By similarity). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (By similarity). {ECO:0000250|UniProtKB:Q14116, ECO:0000269|PubMed:30392956}.
Interaction partners:
- Interleukin-18 receptor 1
- Interleukin-18 receptor accessory protein
- Caspase-1
- Interleukin-18-binding protein
- Apoptosis-associated speck-like protein containing a CARD
- Transcription factor Jun
- Interleukin-1 beta
- Transcription factor p65
- Nuclear factor NF-kappa-B p105 subunit
- Interleukin-1 alpha
Sequence:
MAAMSEDSCVNFKEMMFIDNTLYFIPEENGDLESDNFGRLHCTTAVIRNINDQVLFVDKRQPVFEDMTDIDQSASEPQTRLIIYMYKDSEVRGLAVTLSVKDSKMSTLSCKNKIISFEEMDPPENIDDIQSDLIFFQKRVPGHNKMEFESSLYEGHFLACQKEDDAFKLILKKKDENGDKSVMFTLTNLHQS
Protein: Mitochondrial glutathione transporter SLC25A40 (Solute carrier family 25 member 40) (Q8BGP6)
Organism: Mus musculus (Mouse)
Function: Probable mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- RUN domain-containing protein 3B
Sequence:
MEPETEGPPPTIPVTPLQQMIASCTGAVLTSLMVTPLDVVKIRLQAQNNPFPKGKCFLYSNGLMDHMCVCEEESKKAWYKKPGNFRGTLDAFLKILRNEGIKSLWSGLPPTLVMAIPATVIYFTCYEQLSAFLKTKLGENETRIPIVAGVVARFGAVTVISPLELIRTKVQSKKFSYKELYQFVSMRVSEDGWISLWKGWAPTILRDVPFSAMYWYNYENLKRWLCEKSGLYEPTFMINFTSGALSGSFAAVATLPFDVVKTQKQTQLWTNEYCKFPAPLDMSTWTIMKNIVADKGFSGLFTGLIPRLVKIVPACAIMISSYELGKSFFQKQNVESR
Protein: Opsin 5 (Opsin-5 isoform X1) (Teleost neuropsin) (Q5RIV6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Extra-ocular rhodopsin.
- Parietopsin
Sequence:
MENETSISSGYIPHYLLRGDPFASKLSKEADIVAAFYILVIGILSATGNGYVMYMTFKRKTKLKPPEIMTLNLAIFDFGISVSGKPFFIVSSFSHRWLFGWQGCRYYGWAGFFFGCGSLITMTVVSFDRYLKICHLRYGTWLKRHHAFLSVVFIWAYAAFWATMPVVGWGNYAPEPFGTSCTLDWWLTQASVSGQSFVMCMLFFCLIFPTVIIVFSYVMIIFKVKSSAKEVSHFDTRNKNNHSLEMKLTKVAMLICAGFLIAWIPYAVVSVMSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIYQVIDCKKKCVKSCCFQAWRKKKPSKTSRFYTISGSIKQRPGDEASIEI
Protein: Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha) (P19627)
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Subcellular location: Membrane; Lipid-anchor.
Interaction partners:
- Corticotropin-releasing factor receptor 1
- Metabotropic glutamate receptor 1
- Insulin-like growth factor 1 receptor
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein subunit beta-4
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MGCRQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNSGKSTIVKQMKIIHSGGFNLEACKEYKPLIIYNAIDSLTRIIRALAALKIDFHNPDRAYDAVQLFALTGPAESKGEITPELLGVMRRLWADPGAQACFGRSSEYHLEDNAAYYLNDLERIAAPDYIPTVEDILRSRDMTTGIVENKFTFKELTFKMVDVGGQRSERKKWIHCFEGVTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFDSICNNNWFINTSLILFLNKKDLLSEKIRRIPLSVCFPEYKGQNTYEEAAVYIQRQFEDLNRNKETKEIYSHFTCATDTSNIQFVFDAVTDVIIQNNLKYIGLC
Protein: Sodium-dependent glucose transporter 1 (rNaGLT1) (Major facilitator superfamily domain-containing protein 4B) (Q80T22)
Organism: Rattus norvegicus (Rat)
Function: May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:12590146}; Multi-pass membrane protein {ECO:0000269|PubMed:12590146}.
Interaction partners:
- Sodium/glucose cotransporter 1
- Major facilitator superfamily domain containing 9
Sequence:
MEFRGSGATAVEQHLLQSETPGKNGLQATSSDQVGRTLRWFTTVVLNAAFLGMGVSAAVLGPTFPDLARNVNRNISSLSEIFVGRALGYLGGSVVGGVLFDCMNHFLLLGLSHLLTAAGLYLTPFCKTAALLTAMMSITGVSFGVLDTGGNVLILDLWGDKGAPHIQALHFSFALGAFLAPLLAKLAWGTTASAQNHTEPQLDRSALNRSFEAASDSVLAVPDDMNLLWAYASIGTYVLVLSVFLFAPFFKKRSKQKKSAASAQGARRAKYHRALLCLLFLFFFFYVGAEVTYGSYVFSFATTHVGMEESEAAGLNSIFWGTFAACRGLAIFFATLLQPGTMMVLCNIGSLASSFFLVLFDKSPLCLWIASSVYGASMAATFPSGISWIEQYTTLTGKSAAFILVGAALGLMATPALSGILQGHYPDLPVILYMCLGSAVLTTVLFPVMYKVATLPLDRKQEKSINSEGQKILLSSSRLIKEAK
Protein: Nucleolar protein 10 (Q9BSC4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Interaction partners:
- U3 small nucleolar ribonucleoprotein protein MPP10
- Nucleolar protein 6
- Protein AATF
- RNA cytidine acetyltransferase
- Ribosome biogenesis protein BMS1 homolog
- WD repeat-containing protein 36
- Nucleolar protein 58
- Nucleolar complex protein 4 homolog
- Bystin
- Neuroguidin
Sequence:
MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVECWDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNGALTMAVGTTTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIVKMWNKNSGKIFTSLEPEHDLNDVCLYPNSGMLLTANETPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMVNPFAYEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELREKEEEEEPEGKPSDAESSESSDDEKAWVEEVRKQRRLLQQEEKVKRQERLKEDQQTVLKPQFYEIKAGEEFRSFKDSATKQKLMNKTLEDRLKIEAKNGTLSVSDTTVGSKQLTFTLKRSEQQKKQQEAEKLHRQERKRLRRSAGHLKSRHKRGRSFH
Protein: Phosphoadenosine phosphosulphate reductase domain-containing protein (Q9I1Y8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- ParB/Sulfiredoxin domain-containing protein
- Probable ATP-binding/permease fusion ABC transporter
Sequence:
MAGKHYQDADVHAATLSRLRLVFRNFERVCVAFSGGKDSSVTLQLALDVARELGRSPVDVLFIDLEGQYQATIDHVSEMLGRPDVRPWWVCLPLNLRNASSLEEPYWCCWEPGAEADWVRPLPKQRGVISDPAFFPFYRYRMEFEEFVAGFNAWLAREEPTAFLVGIRSDESLNRYLAVKRRSRAKQCAWTPPGGSAPLAWSARDRANPQAVSFFPIYDWRFEDLWRCVADHGYAYNRLYDQMYRAGVPFSQMRICQPYGDDQRKGLDLFHRIEPRTWFKVVRRVAGANYGARYCRQRFLGYRGGLGLPPSFGTWREYSQFLLRSMPPPLRGIYQRRIERFILWWKQHDYPLAIWPDAGIPALENRRKQPSWRRIALSLLKQDMARSLSFGFSQADIDRLVPGREKRS
Protein: Anaphase-promoting complex subunit CDC26 (Cell division cycle protein 26 homolog) (Q68EK9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). May recruit the E2 ubiquitin-conjugating enzymes to the complex.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 2
- Cell division cycle 16 homolog
- Cyclosome subunit 8
- Anaphase-promoting complex subunit 13
- Anaphase-promoting complex subunit 16
- Anaphase-promoting complex subunit 7
- Anaphase-promoting complex subunit 1
- Anaphase-promoting complex subunit 15.
Sequence:
MLRRKPTRLELKLDDTEEFESVKKELESRKKQRDEVDVVGVATSSEMSGAAGGTADGKTREQMIHERIGYKPHPKPNTLPSLFGNLQF