wanglab/gogpt-training-data huggingface dataset:
Protein: Chromatin-remodeling ATPase INO80 (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (Q6ZPV2)
Organism: Mus musculus (Mouse)
Function: ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9ULG1}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00746, ECO:0000269|PubMed:20971067}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9ULG1}. Chromosome {ECO:0000250|UniProtKB:Q9ULG1}. Note=Localizes to the cytoplasm in quiescent cell. Associates with spindle microtubules during mitosis. Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner. {ECO:0000250|UniProtKB:Q9ULG1}.
Interaction partners:
- Actin-related protein 5
- INO80 complex subunit E
- RuvB-like 1
- Nuclear factor related to kappa-B-binding protein
- RuvB-like 2
- INO80 complex subunit B
- INO80 complex subunit C
- INO80 complex subunit D
- Ubiquitin carboxyl-terminal hydrolase isozyme L5
- Actin-related protein 8
Sequence:
MASELGAGDDGSSTELAKPLYLQYLERALRLDHFLRQTSAIFNRNISSDDSEDGLDDNNPLLPESGDPLIQVKEEPPNSLLGETSGASSSGLLNPYSLNGVLQSESKSDKGNLYNFSKLKKSRKWLKSILLSDESSEADSQSEDNDDEEEELSLSREELHNMLRLHKYKKLHQNKYSKDKELQQYQYYSAGLLSTYDPFYEQQRHLLGPKKKKFKEDKKLKAKLKKVKKKRRRDEEFSSEESPRHHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLNARRRKVWLSIVKKELPKANKQKSSARNLFLTNSRKLAHQCMKEVRRAALQAQKNCKETLPRARRLTKEMLLYWKKYEKVEKEHRKRAEKEALEQRKLDEEMREAKRQQRKLNFLITQTELYAHFMSRKRDMGHDGIQEEILRKLEDSSTQRQIDIGGGVVVNITQEDYDSNHFKAQALKNAENAYHIHQARTRSFDEDAKESRAAALRAADKSGSGFGESYSLANPSIRAGEDIPQPTIFNGKLKGYQLKGMNWLANLYEQGINGILADEMGLGKTVQSIALLAHLAERENIWGPFLIISPASTLNNWHQEFTRFVPKFKVLPYWGNPHDRKVIRRFWSQKTLYTQDAPFHVVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSSSVRWKILLQFQCRNRLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKSAIDENQLSRLHMILKPFMLRRIKKDVENELSDKIEILTYCQLTSRQKLLYQALKNKISIEDLLQSSMGSTQQAQNTTSSLMNLVMQFRKVCNHPELFERQETWSPFHISLKPYEISKFIYRHGQIRVFNHSRDRWLKVLLSPFAPDYIQQSLFHRKGINEGSCFSFLRFIDVSPAEMANLMLQGLLARWLALFLSLKASYRLHQLRSWAEPDGTSHQSYLRNKDFLLGVDFPLSFPNLCSCPLLKSLVFSSHCKAVSGYSDHVVHQRRSATSSLRCCLLTELPSFLCVASPRVTAVPLDSYCNDRSAEYERGVLKEGGSLAAKQCLLNGAPELATDWLSRRSQFFPEPAGGLLSIRPQNGWSFIRIPGKESLITDSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLEEYMVYRKHTYMRLDGSSKISERRDMVADFQTRNDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAKEKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEELEKKLRLRQEEKRQQEESNRVKERKRKREKYAEKKKKEDELDGKRRKEGVNLVIPFVPSADNSNLSADGDDSFISVDSAMPSPFSEISISSELHTGSIPPDESSSDMLVIVDDPASSAPQSRATNSPASITGSVSDTVNGISIQEVPAAGRGHSARSRGRPKGSGSTAKGAGKGRSRKSTAGSAAAMAGAKAGAAAASAAAYAAYGYNVSKGISASSPLQTSIVRPAGLADFGPSSASSPLSSPLNKGNNIPGTPKSLHMTSSLASDSLIRKQGKGTNPSGGR
Protein: Syntaxin-6, putative (Q8IKV1)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Interaction partners:
- Syntaxin, Qa-SNARE family
- Alpha-soluble NSF attachment protein, putative
- Protein transport protein SEC22
- Syntaxin, Qa-SNARE family
- Syntaxin, Qa-SNARE family
- Syntaxin, Qa-SNARE family
- SNARE protein, putative
- Vesicle transport v-SNARE protein VTI1, putative
- Vesicle transport v-SNARE protein, putative
- Vacuolar protein sorting-associated protein 18, putative
Sequence:
MNEQIDPFYEAKQEVDISVNKLQSLYNNWNNIPDKSSISAREKYNLIKEEIKYLNEDLNDLDNSVNIVKKNSYKFNISSQEIEERTQSLRIIRNLLNEITNNINNNVLSYNNNTNNDYNSVILKRQDNDLEELAESAERLHHAAITINTELKDQQKLLDELENEMDISNEKINFVTKKISHYLKTKNPKILSLICYLSLISLVLFFILIVS
Protein: Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) (Q8CE90)
Organism: Mus musculus (Mouse)
Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE.
Subcellular location: Nucleus {ECO:0000269|PubMed:9891090}. Cytoplasm {ECO:0000269|PubMed:9891090}.
Interaction partners:
- C-Jun-amino-terminal kinase-interacting protein 1
- C-Jun-amino-terminal kinase-interacting protein 3
- C-Jun-amino-terminal kinase-interacting protein 2
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase 9
- Mitogen-activated protein kinase kinase kinase 7
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase kinase kinase 1
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- Mitogen-activated protein kinase kinase kinase 11
Sequence:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQLPLANDGGSRSPSSESSPQHPTPPTRPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYEILEVDVASWFKDVMAKTESPRTSGVLSQHHLPFFSTSVTWGAWPLAAQTPFQSGVIRCRGRVPSPRRATGGSGGQPCVCAGGPGPSFTEMGPSPSPMLSNTFFTPDPGACPGASTWGLPRRRLCQLLTTSTPGCC
Protein: Poly(A) polymerase beta (PAP-beta) (EC 2.7.7.19) (Polynucleotide adenylyltransferase beta) (Testis-specific poly(A) polymerase) (Q9WVP6)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Symplekin
- Cleavage and polyadenylation specificity factor subunit 1
- Cleavage and polyadenylation specificity factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 3
- Polyadenylate-binding protein 2
- pre-mRNA 3' end processing protein WDR33
- Poly
- Poly
- Cleavage stimulation factor subunit 3
- Poly
Sequence:
MMPFAVTTQGAQQPAPAPKQFGISSPISLAAPKDTDRELTQKLIETLQPFGVFEEEEELQRRILILQKLNNLVKEWIREISESRNLPQAVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRNDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDSFRLTLRAIKLWAKCHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMIEEFKQGLAITHEILLNKAEWSKLFEAPSFFQKYKHYIVLLASAPTEKQHLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKETADKEEFRTMWVIGLVLKKPENSEILSIDLTYDIQSFTDTVYRQAINSKMFEMDMKIAAMHLRRKELHQLLPNHVLQKKETHLTESVRLTAVTDSSLLLSIDSENSMTAPSPTGTMKTGPLTGNPQGRNSPALAVMAASVTNIQFPDVSLQHVNPIESSGIALSESIPQIPSQPTISPPPKPTMTRVVSSTHLVNHPSRPSGNTATNIPNPILGV
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q5FBD1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSNTSSCSSSGETSPDDTPRGGGTIRVYLPNKQRTVVNVRPGQTVYDSLDKALKVRGLSQDCCAVFRLLEGRKRLTEWDTDITPLVGEELLVEVLDDVPLTMHNFVRKTFFKLAYCDFCHKFLFNGFRCQTCGYKFHQHCSSKVPTVCVDMDTMTKRCVNNTEDCPAILIYPATNSISQSDLPLTSDSPGGELPSSPSNFCLFIRGEDGQSLQRHRSTSTPNVHMVSTLEPGAAGLLEEPFKISTVASSTGYESSPKPSTSPPHLGSPGRKPPKSPSEPKERKQSSSDDKKKVHRGGYRDSSYYWEVHPREVSMLKRIGAGSFGTVFKGKWHGDVAIKILKVTEPTPEQLQAFKNEMQVLRKTRHVNILLFMGFMTRPNFAIITQWCEGSSLYRHLHVTETKFDTMRRIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGWTVKIGDFGLATVKSRWSGSQQVEQPSGSILWMAPEVIRMQDTNPYTFQSDVYGYGVVLYELMSGTLPYSNINNRDQIIFMVGRGYLSPDLSKLYSNCPKSMKRLIIDCLKFKRDERPLFPQILVSIEQVQELLPKIERSASEPSLHRAVHAEDLNPLLLHTTRFL
Protein: A-kinase interacting protein 1 (E9PN38)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLEKQPAAGPQRVLPGEKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEASQPVSTELLTHWVSPPLQLHEPVDMVLRGLFELSL
Protein: Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) (Q8A8E6)
Organism: Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
Interaction partners:
- 6-phosphogluconolactonase
- 6-phosphogluconate dehydrogenase, decarboxylating
- Glucose-6-phosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase
- Enolase
- Hexokinase type III
- Pyruvate kinase
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1
- Fructose-bisphosphate aldolase
Sequence:
MDKFAMIIFGASGDLTKRKLMPALYSLYRDKRLTGSFTVLGIGRTVYSDEDYRSYILGELQQFVKAEEQNLELMSSFVSHLYYLPMDPAKVEGYSQLRERLVELTKEVDPDNLLFYLATPPSLYGVVPLHLKAAGLNTPHSRIIVEKPFGYDLESALELNKIYSSVFDEHQIYRIDHFLGKETAQNVLAFRFANGIFEPLWNRNYIDYVEITAVENLGIEQRGGFYETAGALRDMVQNHLIQLVALTAMEPPAVFNADNFRNEVVKVYESLTPLTETDLNEHIVRGQYTASGNKKGYREEKGVAPDSRTETYIAMKLGISNWRWSGVPFYIRTGKQMPTKVTEIVVHFRETPHQMFRCSGGNCPRANKLILRLQPNEGIVLKIGMKVPGAGFEVRQVTMDFSYAQLGGVPSGDAYARLIDDCIQGDPTLFTRSDAVEASWNFFDPVLRYWKDNPDAPLYGYPAGTWGPLESEAMMHEHGADWTNPCKNLTNTDQYCEL
Protein: Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) (K7EQG9)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
Sequence:
MYGKDGKGTNWMDQGDMECRMQEIDDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
Protein: Hydrogenase-1 large chain (HYD1) (EC 1.12.99.6) (Membrane-bound hydrogenase 1 large subunit) (NiFe hydrogenase) (P0ACD8)
Organism: Escherichia coli (strain K12)
Function: This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth.
Subcellular location: Cell membrane; Peripheral membrane protein.
Interaction partners:
- Hydrogenase-1 operon protein HyaF
- Hydrogenase-2 small chain
- Hydrogenase-1 small chain
- Hydrogenase 1 maturation protease
- Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit
- Hydrogenase-1 operon protein HyaE
- Hydrogenase 2 maturation protease
- Hydrogenase maturation factor HypA
- Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit
- Hydrogenase maturation factor HybG
Sequence:
MSTQYETQGYTINNAGRRLVVDPITRIEGHMRCEVNINDQNVITNAVSCGTMFRGLEIILQGRDPRDAWAFVERICGVCTGVHALASVYAIEDAIGIKVPDNANIIRNIMLATLWCHDHLVHFYQLAGMDWIDVLDALKADPRKTSELAQSLSSWPKSSPGYFFDVQNRLKKFVEGGQLGIFRNGYWGHPQYKLPPEANLMGFAHYLEALDFQREIVKIHAVFGGKNPHPNWIVGGMPCAINIDESGAVGAVNMERLNLVQSIITRTADFINNVMIPDALAIGQFNKPWSEIGTGLSDKCVLSYGAFPDIANDFGEKSLLMPGGAVINGDFNNVLPVDLVDPQQVQEFVDHAWYRYPNDQVGRHPFDGITDPWYNPGDVKGSDTNIQQLNEQERYSWIKAPRWRGNAMEVGPLARTLIAYHKGDAATVESVDRMMSALNLPLSGIQSTLGRILCRAHEAQWAAGKLQYFFDKLMTNLKNGNLATASTEKWEPATWPTECRGVGFTEAPRGALGHWAAIRDGKIDLYQCVVPTTWNASPRDPKGQIGAYEAALMNTKMAIPEQPLEILRTLHSFDPCLACSTHVLGDDGSELISVQVR
Protein: Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (O01259)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- PIGA GPI anchor biosynthesis domain-containing protein
- PMT_2 domain-containing protein
- N-acetylglucosaminylphosphatidylinositol deacetylase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- GPI mannosyltransferase pigv-1
- G domain-containing protein
- Phosphatidylinositol glycan, class T
- GPI mannosyltransferase 1
Sequence:
MATPTGWQKILYRKQPFPDNYSGGDAQFLKELRKNVSVVHYDYKSAVFGCMNFLTHLDMITMYFVLFLNILHSNWSINILYSVFSLTIVLYLFFCKFLIPNPANAKEHARTIFTLFIFAYAFTPVIRTLTTSISTDTIYSTSIITAIFSCFFHDYGVKAPVVSYPTSVSTGLSSAIFLLSRLEGDTPTLLLLVVAFTLHAYGAEFRNRIFHVYPCLSSTIFCFLSLFSIYCISDFSLELSICFALLHIFILFICPLILILKQTGKCTIHGPWDEAVPLKSNT
Protein: Uncharacterized protein C31F10.17c (P87318)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MTTTPLGKMIQDGDFVFQKAKKGTTIPKARKKTLTKDLQVQVAKELEQESSSTFRFAYVFPRKAQNHYYSPSRTHTSSIKKKRPKLCSNINLTPWSLIDSTSNKSIREQSREMGIISIQKWAEQARMRSLCFPKN
Protein: MKIAA1686 protein (Q6ZPK1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
EAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNDQTVATMTSEDKKERPISMINEASNYNMASDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIAMLTAEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITTDSASTKETNNIPNHRVLIRPEVQNHQKNKEISKIEEKRALEAERYGFQKDGQDRPLTKINSVKLNSLLSEYESGPDCPPQNVHYRPINVNSSDGKAVNVSLADVRGGSHPNAGPLATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRAQILARCPEGYRTLPRNSKTRPESICSVTSSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPRHGCLSSPKAMVQVSDQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEVTSPIQRGDVTIDRRHRPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRTPEELTLLLIKLRRQQAELSSVREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKNKISLYCLSQDECRGTLYKYRPEEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRDQMQGQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETGLAGSKPFSSVKYKSEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEDKKIHQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSETEAPVVKGSHFPVGVPLRTKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLERIRRHQQACLREKKKGLSVLGASDPSDVRDSPLRLTQTLRRDDNVKELDTVHRENDVKPDYETPAAQCAHLEDAEPQNADIGRKLKRSEMLYTPEPNGMASEEVTEKERQKEQVHADGSCSPQEETAMTEHQMEGPPEEAESLHEEEETLASCEPAPEIPRENQTTVRSLSPSPDSSTAADPPTPPQLREGSHFMCV
Protein: histidine kinase (EC 2.7.13.3) (Q1CWQ1)
Organism: Myxococcus xanthus (strain DK1622)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- histidine kinase
- histidine kinase
- histidine kinase
- DNA-binding response regulator
- Response regulator
- histidine kinase
- Response regulator
- Response regulator
- Response regulator
- Response regulator
Sequence:
MASARSWTSERTVRRRAARGGIHRARIQRRWDEARRRHRPQNGSERRGGRPQGLGRPVMLETEPRTAGDKEASGARTLKTAAFLRAHQEEVLEDWQRAMRTLHVGHAAQPSWLLDHMPQLLDMLADLIDHGPDEILTTVPDEHAMSRLDAGFDLGQVASEYALLRKCILRRMDAEAAYPAPGELERMEDALDRIVTRTVTSFSQGRQRILQALDRMTQATLDSPSMASLPSRLLTVLAESALSVDSAAFVLVEGDALVVRAAVGLGADEALGVSLERGQGFVGEVLRQRQPLTLRSASTDPRVALPTLKQEGLRAVYGVPLLDGDQLLGVAYMCSRTAFVFSEPDALLFRTMAQRATAHLVQARLRARERQAHADAQRSLAQLDALLASTPLGIAQLDRELRFVRINQALADIDGHSPEAHLGRRFREMAPVTAVGTFEPMFRRTIETGEPVDAVEFTIPGDARTFQASFHPIRTPDQGVLGLSCTVVDVSHHKQAEAVLQRAVDFREQLMAVLGHDLRNPLNAINASAFQLTRSEDLTPPERRAVDRIRKATARMGRMITDILDFARTRLGGGLPVARQPMDFVEVCQATLEELRVSAPERSLVFEASGDTRGNWDPDRVSQVLGNLVANAIQHGQEDRPVCVTVRGEADEVVLKVHNTGEPIAAELMPRLFDPFKNMPAAAPPQDVARKKRSLGLGLYIVSQIVGAHGGHVEVRSNRDQGTTFTVHWPRTLTTLGDA
Protein: Uncharacterized protein YIL102C-A (Q2V2P5)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein YIL102C
- Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit
- Uncharacterized protein YOL097W-A
- Glucose N-acetyltransferase 1
Sequence:
MNRFVIICLLFTYYVIWSLLPIFEIENSNPVVSLLFPISSNVAIFLPIFLLLIGFTLTGSVLGVLLIRSDKKKKV
Protein: Phosphatase Herzog (EC 3.1.3.16) (M9PFN0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Prion-like membrane-associated phosphatase. Phosphatase activity depends on amyloid-like assembly at the membrane. Might have a role in establishment of segment polarity in embryos.
Subcellular location: Cell membrane {ECO:0000269|PubMed:31491385}; Peripheral membrane protein {ECO:0000269|PubMed:31491385}. Note=During embryonic development shows diffuse localization between stages 1-5 and then shows foci formation at the cell membrane that persist till later stages. {ECO:0000269|PubMed:31491385}.
Interaction partners:
- GH07711p
Sequence:
MDATSIITQVSRDDEQLNVYPSYPNDKDAWLGFSGSVWLPDCPADHAQLTHDVDRLKPQKRGLFHSLLCCWRRNRTKTNQNGTQIDGSTTPPPLPDQQRYLLPQVRLTDMHRKCMVIDLDETLVHSSFKPIPNADFIVPVEIDGTVHQVYVLKRPHVDEFLQKMGELYECVLFTASLAKYADPVADLLDKWNVFRARLFRESCVYYRGNYIKDLNRLGRDLQKIVIVDNSPASYIFHPDNAVPVKSWFDDVTDCELRELIPLFEKLSKVDSVYSVLCNSNQPLNNQTNQQQHPQELQQAPNQLHQQLQQQQQQQTISATTVITQATTLSAPTMLNQQQTSPPSPQSELLQKT
Protein: Probable copper-exporting P-type ATPase V (EC 7.2.2.8) (Cu(+)-exporting ATPase) (P9WPS3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Necessary for copper homeostasis and likely functions as a copper exporter. Also required for full virulence.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15952732}; Multi-pass membrane protein {ECO:0000269|PubMed:15952732}.
Interaction partners:
- Uncharacterized protein Rv0968
- Uncharacterized protein Rv0970
- Copper-sensing transcriptional repressor CsoR
- Multicopper oxidase MmcO
Sequence:
MRVCVTGFNVDAVRAVAIEETVSQVTGVHAVHAYPRTASVVIWYSPELGDTAAVLSAITKAQHVPAELVPARAPHSAGVRGVGVVRKITGGIRRMLSRPPGVDKPLKASRCGGRPRGPVRGSASWPGEQNRRERRTWLPRVWLALPLGLLALGSSMFFGAYPWAGWLAFAATLPVQFVAGWPILRGAVQQARALTSNMDTLIALGTLTAFVYSTYQLFAGGPLFFDTSALIIAFVVLGRHLEARATGKASEAISKLLELGAKEATLLVDGQELLVPVDQVQVGDLVRVRPGEKIPVDGEVTDGRAAVDESMLTGESVPVEKTAGDRVAGATVNLDGLLTVRATAVGADTALAQIVRLVEQAQGDKAPVQRLADRVSAVFVPAVIGVAVATFAGWTLIAANPVAGMTAAVAVLIIACPCALGLATPTAIMVGTGRGAELGILVKGGEVLEASKKIDTVVFDKTGTLTRARMRVTDVIAGQRRQPDQVLRLAAAVESGSEHPIGAAIVAAAHERGLAIPAANAFTAVAGHGVRAQVNGGPVVVGRRKLVDEQHLVLPDHLAAAAVEQEERGRTAVFVGQDGQVVGVLAVADTVKDDAADVVGRLHAMGLQVAMITGDNARTAAAIAKQVGIEKVLAEVLPQDKVAEVRRLQDQGRVVAMVGDGVNDAPALVQADLGIAIGTGTDVAIEASDITLMSGRLDGVVRAIELSRQTLRTIYQNLGWAFGYNTAAIPLAALGALNPVVAGAAMGFSSVSVVTNSLRLRRFGRDGRTA
Protein: Chloride channel protein (Q381B7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
Interaction partners:
Sequence:
MSNKLLPSQPPQEADAGGWNRRNVLESLSTNAKDRATSAWFQELARTEEEGDAAFARARPPLFRRAQRTHVRSDEERRRMDNYESIDYSEPQSTVYKKRMAQWKKEPRWLKWVMFIAVGICVGLWSVLLFQTLEYLERRKRGMLRTYLHETHGRGGTEAQTVGGGAGFPMRSTPSGVSWAVAGKCYIIYILWCAGFALLSSLCCLVMPTAAGSGVPEVMAYLNGVMFPRVFNIRNLIVKTLSCIFVVSAGVPVGAEGPIIHIGSLIGAGLPTGRSRTLNCGATSLLSTFRNPRDMRSFISAGAACGVTSAFSAPIGGLLFVMEEVATFFSVRLACMVFVSCLACMCVIQIVNSYMSGWHLLAQSPMTHGEFLPSAIAMFIVNNVPGNHVPLNVYTFIPTVVGSLALGLLAVLYTVSSVRFLRWRRERLFPNTFLRVLEPCLFSLAYNTVCYVLPLAFGCIEIPPYVKDHKAEMKVELFTEFCADRENTFNPLATLALMGPYNSIRVLFSRHTTGLIPWYACLLQLMLYTFSSSYAGGMFVSCGTVIPSLFIGAMGGRLVGTLFNNEVWADPGVLSLIGAASYFSGISRLSFSLIVIMMEMTADLTHITCLMVGVVFARALADRFCHSLYHSLLDLKSVPFLEAQTGVHKFDMFCAKDIMTSPAVTLNTVESIAQVVEVLQSTQHNTFPVVAMAKMTYKGVISRSQLELLLWFMYFRETDGSDVIDSGRLSMLASNVPCGGKNGESVGRVQTKATGIEVCESEGGSACGPFTDCNESIITQAGRSMDTIVPPETNVTDGPPRGPRSHATYADLNKVRECIFWRRLPPMPPVELLSKSTMRCHVDLSPYVDLSTYYVRDVMCISRTYYIFRHLGLRLLPVVDRRHRVIGVITRTNLFGDRLQERLRDAEEAGRLAAVPRA
Protein: Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) (Q03070)
Organism: Rattus norvegicus (Rat)
Function: GTPase-activating protein for p21-rac.
Subcellular location: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLCTSPVNCLDSVCCTSINISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANIYPDINIITGALKLYFRDLPIPIITYDTYTKFIEAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNLMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF
Protein: Kruppel-like factor 3 (Q65ZG6)
Organism: Caenorhabditis elegans
Function: Probable transcription factor which regulates lipid catabolism, storage, and secretion, probably by modulating genes involved in fatty acid desaturation and beta-oxidation, and lipoprotein assembly and secretion. Involved in reproduction, perhaps indirectly.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- C-terminal-binding protein 1
Sequence:
MLKMEQSAPPRYEEDWADVYEFIERDSSRKNVPAIEAIERRLAFSPLITPNPGAKQFAPIHVPGREPPRMLLPPTPHFQAPFSPHPPPVQQVPSYSPPHAPPSYETYPEVYYPPHIICNPYDVPTTSDRNPPYYTEVTTVSAVTLHSMTPPTHKIETPPSSPENSFGPLASQLPAIKMEIPMHPLPHNGELDSTRSSPSSTTSSERSPLQRKSRIESNKRNPTDKKFVVHACTYPGCFKKYSKSSHLKAHERTHSGEKPFVCKWQNCSWKFARSDELTRHMRKHTGDKPFRCSLCDRNFARSDHLSLHMKRHSTI
Protein: Tripartite motif containing 65 (H0YG27)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XALLDAERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQNSACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQRLRVHLEAVARHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGLLLEEGSHPGAPAKPVDLAPVDYRNLTFDPVSANRHFYLSRQDQQVKHCRQSRGPGGPGSFELWQVQCAQSFQAGHHYWEVRASDHSVTLGVSYPQLPRCRLGPHTDNIGRGPCSWGLCVQEDSLQAWH
Protein: AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) (mBLVR1) (O54774)
Organism: Mus musculus (Mouse)
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity). Involved in process of CD8+ T-cell and NK cell degranulation (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- AP-3 complex subunit beta-1
- AP-3 complex subunit mu-1
- AP-3 complex subunit mu-2
- AP-3 complex subunit beta-2
- AP-3 complex subunit sigma-2
- AP-3 complex subunit sigma-1
- AP-2 complex subunit beta
- Vacuolar protein sorting-associated protein 41 homolog
- AP-2 complex subunit mu
- AP-2 complex subunit sigma
Sequence:
MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRVGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSSLLDSAHLVASSTQRNGICEVLYAAAWICGEFSEHLQGPQQTLEAMLRPKVTTLPGHIQAVYVQNVVKLYASILQQKEQAADTEAAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQKLQAKGVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPPSDSESEDEKPKAIFHEEEPRHTRRRQPEEDEEELARRREARKQEQANNPFYIKSSPSPQKRYQDAPGVEHIPVVQIDLSVPLKVPGMPMSDQYVKLEEQRRHRQRLEKDKKRKKKEKGKRRHSSLPTESDEDIAPAQRVDIITEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPVQKHRNAEAVKSPEKEGVLGVEKKSKKPKKKEKKTKEREREKKDKKGEDLDFWLSTTPPPAAAPIPAPSTEELAASTITSPKDECEVLKGEEEDHVDHDQERKSSRHKKKKHRKEKEKEERPRDKKKAKKKQVAPLENGAAAEEEEEPIPPMSSYCLLAESPYIKVTYDIQASLQKDSQVTVSIILENQSSSFLKNMELNVLDSLNTKMTRPEGSSVHDGVPVPFQLPPGVSNEAQFVFTIQSIVMAQKLKGTLSFIAKDDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKLLESGDLSMNSIKVDGISMSFQNLLAKICFYHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGESSVSVDGKCSDATLLSSLLEEMKTTLAQC