wanglab/gogpt-training-data huggingface dataset:
Protein: Inactive tyrosine-protein kinase RYK (Abnormal cell lineage protein 18) (G5EGT9)
Organism: Caenorhabditis elegans
Function: Has no detectable kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor which may act as a receptor for Wnt ligand mom-2. Plays a role in controlling P7.p vulva precursor cell lineage orientation during vulva development. Regulates pop-1 asymmetric distribution in P7.p and its daughter cells. Plays a role in the migration of ALM neurons during embryogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15369677}; Single-pass type I membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:32053105}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes to the basolateral cell membrane of vulval precursor cells. {ECO:0000269|PubMed:32053105}.
Interaction partners:
- Frizzled-4
- Frizzled-2
- Frizzled-4
- Protein mom-5
- Abnormal cell lineage protein 44
- Protein Wnt-1
- Protein Wnt
- Protein Wnt-2
- Protein mom-2
- Vang-like protein
Sequence:
MILRYLIFFAQLWALCLANVNMFISKEEMNRTFGVKAELNYIEMGNVSSYSTKFHYRVMANIDYLSFTWNAVGIVHYEVYVESDDSSVLPIVRIPLKGTVPESLQDFTVEYRCAGHRSGQFAVSLYFTFKYGNKEPLKVKLRQEKICASRDGRRGLNGGYEGHEVDDTDSIDKAFFVIICIAAAFLLIVAATLICYFKRSKKEDMIPTRLPTSFRNSLKSTKSAQPFLLSTPRDGPPTLSAISSAPCSSSSASGNSIIPSKPRNIDVRRALLQLYQDRDAFQSLPLDMEGTFGEVRYAIWRQVDDVLNGDVDDEEDTFCNQEAVYTKTLKNNASPIQLDRFLSDALLFYNITPHQNLSQVACVASFGRFDRPETVTDFPLVCYRHQGFGNLKKFLTICRHGDKTKGAQTLRTHQLVSLATQVSSAVAHIHKYRIVHNDIAARNCLIAEVNGRLQVQLCDSALSRDLFPADYHCLGDNENRPLKWMSPEAIANELYSSAADVWSLGVLLWELMSLGGSPHAEIDPEEVYTMILKGKRLQQPNNCPDQLYEVMLCCWRVLSEDRPSSEQVVHGLRDFNIQLSQYI
Protein: Cytoplasmic 60S subunit biogenesis factor REI1 homolog 1 (Protein REI1-LIKE 1) (pre-60S factor REI1 homolog 1) (Q8H1G5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit. Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity). Can complement the growth defect of a yeast mutant lacking REI1. Required for leaf growth under cold temperature conditions.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P38344}.
Interaction partners:
- 60S ribosomal export protein NMD3
- Eukaryotic translation initiation factor 6-2
- DNAJ protein JJJ1 homolog
- Large ribosomal subunit protein eL24z
- Ribosome assembly factor mrt4
- Eukaryotic translation initiation factor 6-1
- Large ribosomal subunit protein eL24y
- ERBB-3 BINDING PROTEIN 1
- Large ribosomal subunit protein uL3y
- Nucleolar GTP-binding protein 1
Sequence:
MPGLTCNACNMEFKDEEERNLHYKSDWHRYNLKRKVAGVPGVTEALFEARQSALAQEKNKSNEAPMLYTCAICAKGYRSSKAHEQHLQSRSHVLRVSQGTSINGEEDIAIIRQLPRRVQHRGSIDDDSEDEWVEVDSDEELAAEEASDSLSKLNVNESGSAEDMDDDGDADKYELDPTCCLMCDKKHKTLESCMLHMHKHHGFFIPDIEYLKDPEGLLTYLGLKVKRDFMCLYCNELCRPFSSLEAVRKHMEAKSHCKLHYGDGDDEEDAELEEFYDYSSSYVDEAGKQIVVSGETDNTVELVGGSELLITEKSENTTTSKTLGSREFMRYYRQKPRPTSQDSNQIIASLSSRYKSLGLKTVPSKEETLRMKVRKEMSKRGETMRTKIGVKSNVIRNLPNNVPY
Protein: LD25151p (Zinc-finger protein, isoform A) (Zinc-finger protein, isoform B) (Zinc-finger protein, isoform C) (Q9VI24)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- GH22016p
Sequence:
MRVELTPQTCRVCLAQSERLQRLDEIREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNMAYQFREKALRKQMEIEEYCRELGLLDESDVMMIKEEDGSQQQCDEEMYILEETTTGEEEHQEEKGHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQLALQEAAKASLKARRGRVRRGLNSLTTSDGTEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDFRLLHHMRQHEETKLHQNAVMLAESMKVEMVAEQGGGNEIRIQAH
Protein: Nuo1p (A0A1D8PU10)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit
- Complex 1 LYR protein domain-containing protein
- NADH dehydrogenase iron-sulfur protein 4
- Uncharacterized protein
- NADH dehydrogenase 1 alpha subcomplex subunit MCI4
- NADH-ubiquinone oxidoreductase
- NADH-ubiquinone oxidoreductase chain 6
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 2
Sequence:
MSYTATNQPVRAPPLNSDYELIDGDPYFTRVVSYFRFSDYVNWAVITASFPLGMKLWEKIVPSQGKGLKPSVVNPVTLRVSTLLGFFGGFCLNYVKSSQRFLGWRENSREVKLDRFEIKQKLSQGVLPYNEHLSKLDDRNKDISNRNSQYSHALLFVIPWFNTTYHPYHQVDLKKYYINREGEENWGFELKPLDEIYAKYGKKF
Protein: COPII coat assembly protein sec16 (Protein transport protein sec16) (O14029)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Protein transport protein sec13
- Protein transport protein sec24
- Protein transport protein sec31
- Uncharacterized protein C4.03c
- Protein transport protein sec23-1
- Protein transport protein sec23-2
- Small COPII coat GTPase sar1
- Uncharacterized protein C227.19c
- Golgi apparatus membrane protein tvp18
- Probable clathrin heavy chain
Sequence:
MDIESDHEPKESSVDLEGRHDSIRKSFEADDIDVTDENTIFSTSRKEQSTIEPMDSFVENNIANSSSQQSVSEIDIQLPSSEPKEGVKEESNLIESNSLDNVQEINPQNTIGDKSAHTEEESSNDNLVKITAGTIISDIMDEPVVDEDDKLSEEDLSKEDLETTLKGDENYSSSQKEIYDNDETIPKPPSPEVEKIETSTSVENAYITNSQYNDTLDMEDQTSDLITTFEHENEDHEVHEVPSIHGMEGTFETVNLTSEAGNEKEFNNDSVVLNTTPKEMQISSLDAVDKLEDKPVSNDNIKANIESSTTVDRASSQLESENNESTFFVHNQNSSGQHQTLDFVASKPVTDTPELSKENTLVSSENLNDPKPNLPETEVDFGEPLEVEAPSFVVQNNSAVQPTTQKTSEDSTDLHTNEIPNVAQPPSSFEKENNKDTSKLENPDISSSPLSPTEDLFPNDPEEENLFSAALGLNSNTGSQPSETQSKPSIDPSESITVTDNQDSLLFSQLTNNALQAENATKVSENTINDEELIDDSEFTSLMSNFLESSTVQTNKYLPKSSASPPANAPIVSSDVHKNENAGTARRAPQSGAFVASKAKYSSPYDLPEEIVQVAQQKRSVSQNYNRQYSFQPRPATPSNPPRSLPPPSGQVNAPMSQTPNPISFAYQHGTPLATPTMRANSFNSYPASSAEPIRRPATTTVGHTPNLYSPKTNTYNSRHMAYEMTKSHINVISPGPSLQVNAPYTPTSGELGNKVSNPTKEFVSTSSYAPAANTRNAIIREPGILSPLSPRVQPVLSRRESIISMGSSASSYVPLEIAPRPMSSLEHTMNSAMSPGNLQRTANLYKPMTTPNAYNIKNSNQRETKYPYQPQAINYSEVTQPGSSSLPTSGEEANIIRSPGFTPLAAQKDATIYTPSHAQATLYGNMDNNDRDNEGIHDILQSDMEPVLPPHNSAYHANAPVSSHSEGLNNRLPISPLPPQLHKTGTPSHQHGFDTAETTAKQYAPSIPPNFNPNVSIDTMTEGVALPSATLDSDKSSLHKRSAELSRNNSPRPDFLPLPNQPLLHSNLHSPVSPVVDSNEDSRLKFLSTQRPAFSFGPCGTIVMAFSTPSGLYTTSGKGTKFIAGPIKIEKLGDVLTDEYRHLKEFKGPYLASNGKVDKHGKAEAIEWLSKYIDRLNQSLEYDDKNITLKDKLLLLQCLKMLLEVSDRKLIVEKLRPILLPSFEIPEPCNTATSVQELINPEINQDDSPIVASRYCTTSFLHRFYEYLLSGNKDEALTYALQQKQWPYAIIVAHSIDAKTFQGVVRTFCKSEVKESMLRSGVGVNLQLSLQLMSDAHASSMSEFSSSTSLLNLADQSQASNALVAWKELLYNIIANHYSDQKEALRVLGTLLLQENRVYAAHLVYILSLSPDVCSNKSNSLFELVGLSKHNLYPSHDDLFDVTQLTEVLELVFNVYSEKTPVFFTHLVPYRLYEAEVLAEAGEVSAARKYCELIGNYLNRVAKKSNNVDPGFVLRVRDLTQQILENSAGSEDISSSWLGRTVSRPRLDTVLSSLGSKFSKFVAGDPNFDVMRPATVGPGPFGKVASQKNLTVQTNTNNAAMESFYSDRPTSSGPSYQNRTPLTGQESMNMGVYSPYRRSTEIAENMSMDGNAYPYTPASQENPYTPRHSQEDNASVLSQQPLTFYSNVADNSYMPVSASQEPKMGMGTAFNMPTNEVHGVGAEMASPYQPLQPASAHLPNLQPTLAPINQNAYVPSNIAPAMGAMQSAPSAEAVAAPSESLNLNKDRSQQAKQAAAQNVADLVRQEEEKEKQKQKAKKNAESGKKGGAKGWFSKLLRRDESKDQPTVYKAKLGEKSHLHYDKELKRWVNDDGSDLSNQAAPPPPPPMALPKAGPPSAAPTSALPPAGPPAGATAISGNPGMPAPVPLTGKETAVPLSSMPNAPPSVASNAKLPPASNNRKVDPLEDILQAMPPPTTRKARGKTSKRYVDVMRNS
Protein: Nascent polypeptide-associated complex subunit alpha-like protein 2 (NAC-alpha-like protein 2) (Alpha-NAC-like protein 2) (Q94JX9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May promote appropriate targeting of ribosome-nascent polypeptide complexes.
Interaction partners:
- Nascent polypeptide-associated complex subunit beta
- Basic transcription factor 3
- Large ribosomal subunit protein uL18y
- Probable elongation factor 1-gamma 2
- Large ribosomal subunit protein eL18y
- Large ribosomal subunit protein uL24c
- Large ribosomal subunit protein eL42z/eL42y
- Uncharacterized protein T9C5.90
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein uL23y
Sequence:
MSPPPAVVTESADGQPEQPPVTAIAEELEKKLQTDEPIVEDVKDDEDDDDDDEEEEDDDAQGVSGSSKQSRSEKKSRKAMLKLGMKPVTGVSRVTIKRTKNVLFFISKPDVFKSPHSETYVIFGEAKIEDLSSQLQTQAAQQFRMPEIGATSQRAEASTATVEAQVEEDEEEIDETGVEARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELTT
Protein: Alkaline protease secretion ATP-binding protein aprD (E0SC33)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Membrane fusion protein
- Outer membrane exporter of proteases
- serralysin
- serralysin
- serralysin
- Phosphate transporter subunit ATP-binding component of ABC superfamily
- serralysin
- Alkaline proteinase inhibitor
- ATP-binding protein of ABC transporter
Sequence:
MNASSERDRSLFGVLRQFRRSFWSVGIFSAVINVLMLAPSVYMLQVYDRVLASGNGITLLMLTLLMAGLCAFMGALEWVRSLLVVRLGTRIDLALNQDVFNAAFARNLEAGDGRAGLALTDLTLLRQFITGNALFAFFDVPWFPLFLLVLFLLHPWLGMLALGGTVVLVALAWLNQHLTNQPLAEANQQSQQATHLADAQLRNADVIEAMGMLGNLRRRWLARHYRFISLQNLASERAAAVGGASKYSRIALQSLMLGLGALLAIDGKITPGMMIAGSILVGRVLSPIDQLIGVWKQWSSARIAWQRLTRLIAAYPPRPAAMALPAPEGHLSVEQVSLRTVQGNTRLQNIHFSLQAGETLVILGASGSGKSSLARLLVGAQSPTQGKVRLDGADLNQVDKNTFGPTIGYLPQDVQLFKGSLAENIARFGDADPEKVVAAAKLAGVHELILSLPNGYDTELGDGGGGLSGGQRQRIGLARAMYGDPCLLILDEPNASLDSEGDQALMQAIVALQKRGATVVLITHRPALTTLAQKILILHEGQQQRMGLARDVLTELQQRSAANQARMNPTAAMPQ
Protein: GON-4-like protein (GON-4 homolog) (Q3T8J9)
Organism: Homo sapiens (Human)
Function: Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810}.
Interaction partners:
- Histone-lysine N-methyltransferase ASH1L
- Protein cramped-like
- GRB10-interacting GYF protein 2
Sequence:
MLPCKKRRTTVTESLQHKGNQEENNVDLESAVKPESDQVKDLSSVSLSWDPSHGRVAGFEVQSLQDAGNQLGMEDTSLSSGMLTQNTNVPILEGVDVAISQGITLPSLESFHPLNIHIGKGKLHATGSKRGKKMTLRPGPVTQEDRCDHLTLKEPFSGEPSEEVKEEGGKPQMNSEGEIPSLPSGSQSAKPVSQPRKSTQPDVCASPQEKPLRTLFHQPEEEIEDGGLFIPMEEQDNEESEKRRKKKKGTKRKRDGRGQEGTLAYDLKLDDMLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFEPKMTRSKLKEVVEKGVVIPTWNISPIKKANEIKPPQFVDIHLEEDDSSDEEYQPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQSSEMTETDEESGILSEAEKVTTPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCMDSFQPMDDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPNTADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNELMEELFETFQDEMGFSNMEDDGPEEEECVAEPRPNFNTPQALRFEEPLANLLNEQHRTVKELFEQLKMKKSSAKQLQEVEKVKPQSEKVHQTLILDPAQRKRLQQQMQQHVQLLTQIHLLATCNPNLNPEATTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNLMGAMQLIEDFSTHVSIDCSPHKTVKKTANEFPCLPKQVAWILATSKVFMYPELLPVCSLKAKNPQDKIVFTKAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQLTVRIKNLNMNRAPDNIIKFYKKTKQLPVLGKCCEEIQPHQWKPPIEREEHRLPFWLKASLPSIQEELRHMADGAREVGNMTGTTEINSDRSLEKDNLELGSESRYPLLLPKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQPSPSLQPSFNPGKTPARSTHSEAPPSKMVLRIPHPIQPATVLQTVPGVPPLGVSGGESFESPAALPAVPPEARTSFPLSESQTLLSSAPVPKVMLPSLAPSKFRKPYVRRRPSKRRGVKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQTIPITTLLVNPTSFPCPLNQSLVASSVSPLIVSGNSVNLPIPSTPEDKAHVNVDIACAVADGENAFQGLEPKLEPQELSPLSATVFPKVEHSPGPPLADAECQEGLSENSACRWTVVKTEEGRQALEPLPQGIQESLNNPTPGDLEEIVKMEPEEAREEISGSPERDICDDIKVEHAVELDTGAPSEELSSAGEVTKQTVLQKEEERSQPTKTPSSSQEPPDEGTSGTDVNKGSSKNALSSMDPEVRLSSPPGKPEDSSSVDGQSVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEEDEMSSASEESVLSVPELQETMEKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMESLQKEDEMTDEAVGDSAEKPPTFASPETAPEVETSRTPPGESIKAAGKGRNNHRARNKRGSRARASKDTSKLLLLYDEDILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRRTAVDLYKSLQILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTEEKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKETEWPDGAKDCACSCHEGGPDSKLKKSKRRSCSHCSSKVCDSKSYKSKEPHELVGSSPHREASPMPGAKEAGQGKDMMEEEAPEERESTEATQSRTVRTTRKGEMPVSAGLAVGSTLPSPREVTVTERLLLDGPPPHSPETPQFPPTTGAVLYTVKRNQVGPEVRSCPKASPRLQKEREGQKAVSESEALMLVWDASETEKLPGTVEPPASFLSPVSSKTRDAGRRHVSGKPDTQERWLPSSRARVKTRDRTCPVHESPSGIDTSETSPKAPRGGLAKDSGTQAKGPEGEQQPKAAEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGAQPQTFNIISQQLGNKTPAEVSHRFRELMQLFHTACEASSEDEDDATSTSNADQLSDHGDLLSEEELDE
Protein: Phosphofurin acidic cluster sorting protein 1 (PACS-1) (Q8K212)
Organism: Mus musculus (Mouse)
Function: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O88588}. Note=Localizes in the perinuclear region, probably the TGN. {ECO:0000250|UniProtKB:O88588}.
Interaction partners:
- WD repeat-containing protein 37
- Furin
Sequence:
MAERGGAGGGPGGSGGGSSQRGSGVAQSPQQQPQQQPPQPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGPGPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQGSKRILRSNEIILPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKVKSTWIKNQDDSLTETDTLEITDQDMFGDVSTSLVVPEKVKTPMKSSKADLQGSASPSKVEGTHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGSQSYLSSILRFFVKSLASKTPDWLGYMRFLIIPLGSHPVAKYLGSVDSRYSSTFLDSAWRDLFSRSEPPVSEPLDVVGRVMQYVNGATTTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPHAGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQLAAQWPTHVKHFPVGLFSGSKTT
Protein: F-box/SPRY domain-containing protein 1 (F-box only protein 45) (mFbxo45) (Q8K3B1)
Organism: Mus musculus (Mouse)
Function: Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P0C2W1}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P0CH38}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P0CH38}. Nucleus {ECO:0000250|UniProtKB:P0C2W1}. Note=Secreted by a non-classical mechanism. {ECO:0000250|UniProtKB:P0C2W1}.
Interaction partners:
- S-phase kinase-associated protein 1
- E3 ubiquitin-protein ligase MYCBP2
- Cullin-1
- F-box only protein 11
- SPRY domain containing 3
Sequence:
MAAPGPGAGAASGGASGGGAGAGGGASAGSGSSGVGGRLPSRVLELVFSYLELSELRSCALVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKVRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKACLYPAVSAVYGNTEVTLVYLGKPLDG
Protein: Bone morphogenetic protein 3 (BMP-3) (Q8BHE5)
Organism: Mus musculus (Mouse)
Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
Subcellular location: Secreted.
Interaction partners:
- Activin receptor type-2B
- Activin receptor type-2A
Sequence:
MAGARGLLCLWLGYFCLNLAQGQRPNLHLPGLRETEPSDRATGGSPSPDLRPHDKVSEHMLWLYDRYSGSSRVQATRTPGSQLPGPQPLRGGNTVRSFRAAAAGTPQTKGLHTFNLTSLTKSENILSATLYFYVGELVNISLSCPEPQGCSHHTQRQHIQIDLSAWILKSNQSQLLGHLSVDVVRPYRDSVSWLSKDITQLLRKAKQNEEFLIGFNITSRAHELPKRMLFFPEPYILVYANDAAISEPESVVSSLQRHRDFTAGTGPRLDSHVREALSVERRKKRSTGILLPLQNNELPGAEYQYKEEGAWEERKPYKSLQTQPPEKSRNKKKQRKGSHQKGQTLQFDEQTLKKARRKQWVEPRNCARRYLKVDFADIGWSEWIISPKSFDAFYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVDSCACR
Protein: AFG1-like ATPase family protein (Q8L517)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At2g24860/F27C12.22
- Exocyst complex component EXO70E2
- non-specific serine/threonine protein kinase
- Alpha-crystallin domain 32.1
- Protein HIGH CHLOROPHYLL FLUORESCENCE PHENOTYPE 244
- Glyoxysomal processing protease, glyoxysomal
Sequence:
MRPIIRLSSLSRIRWALRNNQERYSSTFYSKSRKLLIGVNQNQALLNTNTDNSSLYSRSSIFRGLSAEAVEAADPATTRVTVSDVNRTGPLVEYERRISNGELMTGDICQISALRELQRLYDELVDSVDTCRLDRYNTSDKSSRSRWFWSRLMPQTSYSPVKGLYLYGGVGTGKTMLMDLFFDQLPCTWKKQRIHFHDFMLSVHSRLQKHKGLSDPLEVVAQEIAHDAILLCLDEFMVTDVADALILNRLFGHLFSNGVILVATSNRNPDKLYEGGLQRDLFLPFISSLKERSVVHEIGSAVDYRKLTSAEQGFYFIGKDLSTLLKQKFRQLIGDNVVARPQVVEVVMGRKLQIPLGANGCAYFPFEELCDRPLGAADYFGLFKKFHTLALDEIPVFGLHNRTAAYRFVTLVDVMYENRARLLCTAEANPQELLEKIITISEAKSMGPRTSSRSRKNDVTELCVDNELGFAKDRTISRLTEMNSKEYLEHHAITHNL
Protein: Cadherin-13 (Heart cadherin) (H-cadherin) (Truncated cadherin) (T-cad) (T-cadherin) (Q9WTR5)
Organism: Mus musculus (Mouse)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27834691}; Lipid-anchor, GPI-anchor {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:27834691}.
Interaction partners:
- Adiponectin
- Adiponectin receptor protein 2
- Adiponectin receptor protein 1
- Catenin beta-1
- Catenin alpha-1
- Ras association domain-containing protein 1
- Cadherin-9
- Cadherin-8
- Cadherin-11
- Catenin alpha-2
Sequence:
MQPRTPLTLCVLLSQVLLVTSADDLECTPGFQRKVLHIHQPAEFIEDQPVLNLTFNDCKGNEKLHYEVSSPHFKVNSDGTLVALRNITAVGRTLFVHARTPHAEDMAELVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPEGSKFRLTGKGVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDASGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIVIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTKQENISVGSVLLTVNATDPDSLQHQTIRYSIYKDPAGWLSINPINGTVDTTAVLDRESPFVHNSVYTALFLAIDSGNPPATGTGTLLITLEDINDNAPVIYPTVAEVCDDARNLSVVILGASDKDLHPNTDPFKFEIHKQTVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCKNSKVDCNGAGALHLSLSLLLLFSLLSLLSGL
Protein: Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (O88866)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MPAAAGDGLLGEPAAPGGDGGAEDTTRPAAACEGSFLPAWVSGVSRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLDEAEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKAMNPLPTQLSTGAVNFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSICYKTQLYQIEKCRATKEPYEASLDTWTRDFEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSPSLITQLQSTKALLKDRKASKSGFPDKDSFVCRNLFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKLEPHQPGPGSASILPKEEPLLLDMVRSFESVDREDHIELLSPSHHYRILSSPVSLARRNSSERTLSQGLLSGSTSPLQTPLHSTLVSFAHEEKNSPPKEEGVCSPPPVPSNGLLQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSSERSLDASMSPLQPTAPSSLSFDMADGVKGQC
Protein: Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (xTIF2) (Q9W705)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (By similarity). Required in a nuclear receptor pathway to suppress expression of dorsal mesoderm genes. May play a role in the positive regulation of the circadian clock (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q15596}.
Interaction partners:
Sequence:
MGENLSDPSRAEPRKRKESLDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNLNFKPDKCAILKETVKQIRQIKEHEKTAAANEDEVQKADVSSTGQSVIDKDALGPMMLEALDGFFFVVNREGNVVFVSENVTQYLRYNQEELMNTSVYSILHVGDHSEFIKNLLPKSLVNGVPRRNSHTFNCRMLVKPMMECEEERHDGQETHQKYESMQCFAVSQPKSIKEEGEDFQSCLICVARRVPVKERPVPPPSESFTTRQDFQGKITSLDTTSMRALMRPGWEDMVRRCIQRFHSQHDGEISYSRRHHQEVLRQGHATSPFYRFSLSDGTTVVAQTKSRLMRSQTNNEPPLVLSLHVLQREQNVCGLNQDLAGQAMGKTLNPVQSSSPAHQAMYGGNPGQDTTISSNMNYAISGPKEQMGLATGRFVGSGGMNHISSLQATTPQGNNYALKMNSPSHGSPGMGQGQPNSMLSPRHRVSPGVAGSPRIAPSPFSPAGSLHSPVSVCSSTGNSHSYTNSSLNALQALSEGQGPLAPPLSSPDLKGGNLQHSPGNMNPPQLRKMGSIDSKESFGLYEEQPESATGQGESGCHSNEQKDCGENLSSVVDKTEGQSRLLDGKGQQKLLKLLTTKSDQMEPSTLPSNTLGDMNKDSLSNFASNSMSASAHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESNSTGPGSEVTIKQEPVSPKKKEHALLRYLLDKDDTTDNVADITPKLERADNKVDPSSCPKLSAVKAEKEEPNFGHTDQPGSDFDNLDEILDDLQNSQLSQLFSDTRHDGNSADKQAIMNDLMQLAGENSTGLPAWAQKQRMLRMQQNNGFNSQLAAQLGRLPNQNLPLDIHFQSQASAGSFAQMRSSGPYTTVPQSGVINNQAMMGSQGNVRNSSPGIVGVNGPRPPLKPGDWGSQASAVRPACPTTSTAMNRHDMSRSPTASIPMRPGSQVCPRQVLQSAVMNMGSSELDMNISGPQYTQQQAPPNQTAPWPNRILTIEQPSFNNQNRQPFGSPADDLICQPIVSESPADDGNLLDQLYMALRNFDGLEEIDRALGIPEMVSQGQAVEQESFGSPESNLMMEQKPPVYNHAYANQGQMAQNSYQPMQDPGFNPMGQRPSYGILRMQNRPGLRPTGMVQNQPNQLRLQLQHRLQAQNRQQLMNPINNVSNMNLAMRPGVPGQLREQGPINAQMLAQRQREILSQHLRQKQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHRAMMMRSQGLAMPPNMVGSGGIPASINSPRIPQGSTQQFPFPPNYGTGIPSPPPFTSPFSPVPPSPGSQSLSHSSLHGSQMNLANQGIMGSMGGQYGPVMNPQMQHNAFQFANSGMSQQSDPGFTGATTPQSPIMSPRMGHIQSSMMQQSQANPAYQSELNGWAQGNPAGNSMFSQQSPPHFGQQSGTSMYNSNNMNISVSMAANGNGMNNMNQMTGQINMTSVTSVPTSGLSSMGPEQKYC
Protein: Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (P55272)
Organism: Rattus norvegicus (Rat)
Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity).
Interaction partners:
- cyclin-dependent kinase
- Cyclin-dependent kinase 4
- G1/S-specific cyclin-D1
- G1/S-specific cyclin-D2
- Myc proto-oncogene protein
- G1/S-specific cyclin-D3
- E3 ubiquitin-protein ligase Mdm2
- Cellular tumor antigen p53
- Tumor suppressor ARF
- Cyclin-dependent kinase inhibitor 1
Sequence:
MLGGGSDAGLATAAARGQVETVRQLLEAGADPNAVNRFGRRPIQVMMMGSAQVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLMVLHKAGARLDVCDAWGRLPVDLAEEQGHRDIARYLHAATGD
Protein: Leucine-rich glioma-inactivated protein 1 (Q8K4Y5)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors.
Subcellular location: Secreted {ECO:0000269|PubMed:16990550}. Synapse {ECO:0000269|PubMed:16504945}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1}.
Interaction partners:
- ADAM metallopeptidase domain 22
- ADAM metallopeptidase domain 23
- ADAM metallopeptidase domain 11
- Potassium voltage-gated channel subfamily A member 5
- Contactin-2
- Potassium voltage-gated channel subfamily A member 1
- Disks large homolog 4
- IgLON family member 5
- Inactive dipeptidyl peptidase 10
- A-type potassium channel modulatory protein DPP6
Sequence:
MESESIRRMGNACIPLKRIAYFLCLFSVVLLTEGKKPAKPKCPAVCTCSKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSPKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFANKFIKIQDIEVLKIRKPNDIETFKIEDNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARPPLTLRTPHLILSSSSQRPVIYQWSKATQLFINQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA