wanglab/gogpt-training-data huggingface dataset:
Protein: LRR receptor-like serine/threonine-protein kinase GSO1 (EC 2.7.11.1) (Protein GASSHO 1) (Protein SCHENGEN 3) (C0LGQ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with GSO2, receptor-like serine/threonine-kinase required during the development of the epidermal surface in embryos and cotyledons. In coordination with GSO2, regulates root growth through control of cell division and cell fate specification. Controls seedling root growth by modulating sucrose response after germination. Receptor of the peptide hormones CIF1 and CIF2 required for contiguous Casparian strip diffusion barrier formation in roots. Required for localizing CASP proteins into the Casparian strip following an uninterrupted, ring-like domain, to trigger endodermal differentiation and thus regulate potassium ion (K) homeostasis. Involved in the maintenance of water transport and root pressure. May also be involved in the regulation of suberin accumulation in the endodermis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25233277}; Single-pass type I membrane protein {ECO:0000255}. Note=Localized into a broader band at the endodermal plasma membrane, embedding growing CASP microdomains. In endodermal cells, first observed on all cell sides, but quickly relocated in the transversal and anticlinal sides of the plasma membrane, but excluded from the Casparian strip membrane domain (CSD). {ECO:0000269|PubMed:25233277}.
Interaction partners:
- Casparian strip membrane protein 1
- Dirigent protein 10
- Magnesium dechelatase SGR1, chloroplastic
- Protein CASPARIAN STRIP INTEGRITY FACTOR 2
- Transcription factor MYB36
- Subtilisin-like protease SBT2.4
- Casparian strip membrane protein 3
- Peroxidase 64
- AT5g50150/MPF21_17
- Transcription factor bHLH95
Sequence:
MQPLVLLLLFILCFSGLGQPGIINNDLQTLLEVKKSLVTNPQEDDPLRQWNSDNINYCSWTGVTCDNTGLFRVIALNLTGLGLTGSISPWFGRFDNLIHLDLSSNNLVGPIPTALSNLTSLESLFLFSNQLTGEIPSQLGSLVNIRSLRIGDNELVGDIPETLGNLVNLQMLALASCRLTGPIPSQLGRLVRVQSLILQDNYLEGPIPAELGNCSDLTVFTAAENMLNGTIPAELGRLENLEILNLANNSLTGEIPSQLGEMSQLQYLSLMANQLQGLIPKSLADLGNLQTLDLSANNLTGEIPEEFWNMSQLLDLVLANNHLSGSLPKSICSNNTNLEQLVLSGTQLSGEIPVELSKCQSLKQLDLSNNSLAGSIPEALFELVELTDLYLHNNTLEGTLSPSISNLTNLQWLVLYHNNLEGKLPKEISALRKLEVLFLYENRFSGEIPQEIGNCTSLKMIDMFGNHFEGEIPPSIGRLKELNLLHLRQNELVGGLPASLGNCHQLNILDLADNQLSGSIPSSFGFLKGLEQLMLYNNSLQGNLPDSLISLRNLTRINLSHNRLNGTIHPLCGSSSYLSFDVTNNGFEDEIPLELGNSQNLDRLRLGKNQLTGKIPWTLGKIRELSLLDMSSNALTGTIPLQLVLCKKLTHIDLNNNFLSGPIPPWLGKLSQLGELKLSSNQFVESLPTELFNCTKLLVLSLDGNSLNGSIPQEIGNLGALNVLNLDKNQFSGSLPQAMGKLSKLYELRLSRNSLTGEIPVEIGQLQDLQSALDLSYNNFTGDIPSTIGTLSKLETLDLSHNQLTGEVPGSVGDMKSLGYLNVSFNNLGGKLKKQFSRWPADSFLGNTGLCGSPLSRCNRVRSNNKQQGLSARSVVIISAISALTAIGLMILVIALFFKQRHDFFKKVGHGSTAYTSSSSSSQATHKPLFRNGASKSDIRWEDIMEATHNLSEEFMIGSGGSGKVYKAELENGETVAVKKILWKDDLMSNKSFSREVKTLGRIRHRHLVKLMGYCSSKSEGLNLLIYEYMKNGSIWDWLHEDKPVLEKKKKLLDWEARLRIAVGLAQGVEYLHHDCVPPIVHRDIKSSNVLLDSNMEAHLGDFGLAKVLTENCDTNTDSNTWFACSYGYIAPEYAYSLKATEKSDVYSMGIVLMEIVTGKMPTDSVFGAEMDMVRWVETHLEVAGSARDKLIDPKLKPLLPFEEDAACQVLEIALQCTKTSPQERPSSRQACDSLLHVYNNRTAGYKKL
Protein: Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) (Q09741)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Ornithine decarboxylase
- S-adenosylmethionine decarboxylase proenzyme
- S-methyl-5'-thioadenosine phosphorylase
- Putative agmatinase 1
- Putative agmatinase 2
- Putative agmatinase 3
- S-adenosylmethionine synthase
- Arginase
- Saccharopine dehydrogenase [NADP
- Hydrolase C26A3.11
Sequence:
MSVQELSHPLIKDGWFREINNMWPGQAMTLKVKKVLYAGKSKYQDVLVFESETYGHVLVLDGAIQATERDEFSYQEMIAHLALNSHPNPKKVLVIGGGDGGVLREVVKHECVEEAILCDIDEDVIKVSKQYLPEMSAGFNHPKVKVHIGDGFKFLQDYQNTFDVIITDSSDPDGPAEALFQKPYFQLLSDALRGGGVITTQAECMWIHLGVISNVLTAVKTVFPNVRYAYTTIPTYPSGSIGFVVASKDASIDLSKPLRKWSPEEENKLCKYYNSEIHAASFVLPTFARDVVDKATSS
Protein: Uncharacterized membrane protein C3B8.06 (O59714)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- ATPase get3
Sequence:
MDGMHMNSTGDNPIEIDFENYANHMNKFLMAHIICMIIAYVFILPAGIVLAMAKSKAHIPVQIVYVILTLIGYIFAHISHHKASPENYYKGNIHRPVGRFFMWITFLIAIVGITTSILKKRMLKEYQPAAEAPGAMEDPEQALQRNSLDDGAPLLPREGNSSDEYLPPQSSRRDVSSEKPSIPSISFINIRSWRTIPKKWCVLQVLRYFHRILGHLWLYVGFFESCTGIVLLAGIFKGQHIFNGLAHWIKGAIFLWYGILSFGEYLGAFSEYGWAWNVVPKQLSEKRFAKYVPTKEMVESFLLFAYGVSNVWLEHLGNTDGKWNHHDLQHASLAFMLWWAGLCGILVESKVVHRLLNATLSATLGQRRSEDSEHSENGLPSYNVFPALTVFFTGIMMSAHDQTNHVSTVIHVLWGRLLAAAAIARICTYIMLYLKPPSSPWPTRPPTEIITSFCLICGGAMFMASSYDVVNKIRLNEMSPMLIMNISVAFTCIVMGLEVMFLILKGYASSR
Protein: Add3a protein (Adducin 3 (Gamma) a) (Q7ZUA1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
Interaction partners:
Sequence:
MSGEPRQEVVTTPPPPSVGKREGYFDRVNENDPEYLRARNMSPDLRQDFNMMEQKKRVTQILQSPAFKDELEGMIQEQMNKGNNPTGLLALRQIADFFMSSSVAGFSTSPLSLGMVTPINDMFSVESSTMVKGEKQTRCKLASLYRIVDLFSWAHFASCYITVRVSKEQDHILIIPRGLSFAEASASNLVKVNILGDVIDQGSTNLRIDAAGFSPHAAIYSIRPDVRCIVHISTPATAAVSSMKCGLLPISQEALILGDIAYYNYQGSLDEQEERVELQKALGPTAKVLVLRNHGIVALGGTIEEAFHYIYGAQYACEIQVNAFSCAGGMENLIVLDLEKFKARTQGVAQVGVNMGSQQKWRLGELEFESLMRMLDNLGYRTGYTYRHPIVREKPRHKSEVEIPATVTAFMFDEDDAPRFPLKLLQQRQQREKTRWLNSPNCYMKVNVADGASEENRRTKTTWMKSDDGGNASGTPIRIEDPNQFVPLNTNPSEVLQKRNKIREQNRFDVMTAGPQSQKLAGIVVERPPPYMGNDEEETGPLPPNPFSELNEKEEHQRRLRIDADEEQLTSDDASTLSQSVSPQRTPAKEENHTGVMLNGKDDHGDEEELIKRVSQLTTSLESMEISVRSGEKIEEALTPESSPSKSPNKKKKKFRTPSFLKKNKKKEKVEA
Protein: GH03322p1 (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform B) (Q0KHX4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLHSNYLFLIGGCCLVFAVSAQIPITPRRCPANETFLACGPDCQTECATLGKPCLVRHIRCPDGCYCNKGFARNAAGTCIPLRRCNEGGYGN
Protein: Protein YiaL (P37673)
Organism: Escherichia coli (strain K12)
Interaction partners:
- 2,3-diketo-L-gulonate reductase
- 2,3-diketo-L-gulonate TRAP transporter large permease protein YiaN
- 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM
- 2,3-diketo-L-gulonate-binding periplasmic protein YiaO
- Putative L-ribulose-5-phosphate 3-epimerase SgbU
- 3-keto-L-gulonate-6-phosphate decarboxylase SgbH
- L-xylulose/3-keto-L-gulonate kinase
- L-ribulose-5-phosphate 4-epimerase SgbE
- DNA-binding transcriptional repressor YiaJ
Sequence:
MIFGHIAQPNPCRLPAAIEKALDFLRATDFNALEPGVVEIDGKNIYTQIIDLTTREAVVNRPEVHRRYIDIQFLAWGEEKIGIAIDTGNNKVSESLLEQRNIIFYHDSEHESFIEMIPGSYAIFFPQDVHRPGCIMQTASEIRKIVVKVALTALN
Protein: Complement C1q subcomponent subunit A (P02745)
Organism: Homo sapiens (Human)
Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Subcellular location: Secreted.
Interaction partners:
- Complement C1q subcomponent subunit B
- Complement C1q subcomponent subunit C
- Complement C1s subcomponent
- Complement C1r subcomponent
- Complement C4-A
- Plasma protease C1 inhibitor
- Complement C4-B
- V-set and immunoglobulin domain-containing protein 4
- Complement C2
- Calreticulin
Sequence:
MEGPRGWLVLCVLAISLASMVTEDLCRAPDGKKGEAGRPGRRGRPGLKGEQGEPGAPGIRTGIQGLKGDQGEPGPSGNPGKVGYPGPSGPLGARGIPGIKGTKGSPGNIKDQPRPAFSAIRRNPPMGGNVVIFDTVITNQEEPYQNHSGRFVCTVPGYYYFTFQVLSQWEICLSIVSSSRGQVRRSLGFCDTTNKGLFQVVSGGMVLQLQQGDQVWVEKDPKKGHIYQGSEADSVFSGFLIFPSA
Protein: Transmembrane 9 superfamily member (Q9V3N6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MQSGALARPCLAIVLLAGVVLVADSFYVPGVAPVEFVQDQKIDVKAVKMTSSRTQLPYQYYSLRFCYPKNGTLIFKSENLGEVLRGDRIVNTPYEVRMNQQVNCRLLCNQKDRPLTWSKEDSALVAERIQHEYFVHLLVDNLPVATRIVSVNNPAEVTYEHGYRLGQVDGDNIYINNHLKFILSYHMHSKDKYRVVGFEVETVSVSHKELKFHGDTCNFPDSARPQLVNPNGETQLYFTYSVEWKESKVSWASRWDIYLGMRDVQIHWFSIINSLVVVFFLSGILTMIMIRTLRRDIARYNTDDNIEDTLEETGWKLVHGDVFRPPKNTRLFSAIIGSGIQIFFMALITIFFAMLGMLSPSSRGALMTSGIFMYVFMGTIAGYYAARLYKTMKGREWKRAAFLTATLYPGIVFGTGFFLNFFIWDKSSSGAVPFTTMISLLLLWFGISVPLVYLGFYLGYRKQPYQHPVRTNMIPRQVPTQHWYMNAVLSTLMAGILPFGAVFIELFFVFTAIWQNQFYYLFGFLFLVFCILVVSCAQISIVMTYFQLCGEDYRWWWRSFVVSGGSAVYVLFYSIFYFFTKLEITEFIPTLLYLGYTGLMVLTFWLLTGSIGFFAAYVFILRIYGAVKID
Protein: Uncharacterized protein (A0A1S4H5V7)
Organism: Anopheles gambiae (African malaria mosquito)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRHLASASLLVITLLINFVHGILIVGPKHIRAGQNYTVILSSFESNTNERNLLLQLDGLSAGGKKLLHLGQPTRVQPLSNSVISFPLPESLPAGSYKLTIDGQNGFKFHREADLLLAASTTTALVQLSKPIYKPGDVLQFRVIVLGGDLKPPAPSVTATVIVHDPQRNVIRRWTAVSLQLGVFEEQLQIGTVPLLGRYTITVTVTGANEIVSKTFDVREYVLPAFEVAVKARAVPLEKHQRLNLTLSARYYTGQPVRGVATVELYLEDDKLDQRRVVGVYGAIQLDLPFNEHLSVYDDSQDVRVHVAFTQDETNRTIYKEQRITVYKLPYRVELVKEQPEFRAKVPFDCQLRVRYQDGTPAKGAAFEVKVEGAYTTDRRVAYTSDAAGVIKLTLQPEASSESIDITVNAGSEELLYERISKREASKAFLQVKLDSDVKIGKPFKLKVTCNEELSFFMYYVVSRGVIVDSAFLQPKKVTEHFIEIEASDQMVPRSKVIVVTVAKNVVLCDFVDIDFEDLRNNFDLQIDRTEIRPGDQLQLNMRGPPGAFVALAAYDKSLLQYSNNHDIFWEDVWGVFDKFYSVERNEFDLFHSLGLFARTMEHITFDKANDQTARDGSSSSKNGPSNSQASFRTNFLESWLWKTDKIGSSGSATTKESVPDTITAWHLTGFSIDPVYGLGIIKQPLQLTTVQPFYIVPNMPYSIKRGELVELQFIVFNNFPKKYKASVTLFSVDNQTEFVGRPATETSYTKSIEASPDTGVPVAFLIKARKLGEMTVRVDASIEPAKDSIESVIRVIPESLVKREMISRFFCHNTYQNQSFVLGLDFDRKADAGTRKIDFILTPNILTSVMDNLESLLSVPTGCGEQNMMRLVPIVLVLDYLTSIGSADKQLTAKAIGLLRAGYQNQMRYRQPDGSFGLWEKSGGAVFLTAFVGKTLATAAKYISEIEPSMVEQAFDWLAARQHSTGRFDEVGPVFHRDMQGGLRQGIALTSFVLIALLEQPKVATKHRAAIEKGIDYVTQTLGSIEDSYDLAIATYALLLQKHSSGERFLEKLIGLSTVQQNGTERFWARDAHGIETTAYGLLSFVLAEKYVDGTSIMRWLVKQRYTPGSFPRTQDTFVGLKALTKLAEKISPSRNDYSVQLRHAGRKKEFRVTSQDIGTLQNAQQGVDETAQLELHVAGIGFGLLQVVYEYGVDLRNFTAQFVLELQKSVTNANHQLQLEVCSSFTPQLSDGRSNMVLVEVNFPSGYTVEQRGQPITGATKHNPIQKTEVRFGATSVVVYYNSMGPERNCFTITAYRRQKVTLKRPAYVLVHDYYDPKLNAIKMYQVDD
Protein: Pre-mRNA-splicing factor BRR1 (Bad response to refrigeration protein 1) (Q99177)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in mRNA splicing. Required for snRNA accumulation and manufacture of snRNPs.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein-associated protein B
- U2 small nuclear ribonucleoprotein A'
- Small nuclear ribonucleoprotein Sm D3
- U1 small nuclear ribonucleoprotein A
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein G
- Protein LOT5
Sequence:
MKRGESQAPDAIFGQSRAFALSDSSVNPDVIEYLKSVRQEALRTNAISIKNHMNLQKRTRHKSSMYDDEDEGALKRHAISPSLIRLQRNVEIWVRWFNSVKATVLTNAYEFTGYEDETLDLLLLFLKNYLEDMPSKCTTVEKIISVLNQHSFPEKAEEKEENLQIDEEWAKNILVRLEKTKIDSVEDVKKVITEGDKHELVGYNQWFQYLINNEPQHTTFHEKITSKQLWVLIKYMSNTWIKEIHKKGRHYRRLQDWLFYILVHTPERVTAEYTSILRDLGKKCLELIQKKPVEAHENKITLPKEMAELNVEIPAAVENMTITELTVSVIAVNYGQKDLIE
Protein: Uridine diphosphate glucose pyrophosphatase NUDT14 (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 14) (Nudix motif 14) (Q9D142)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Uridine diphosphate glucose pyrophosphatase NUDT22
- ADP-sugar pyrophosphatase
- 8-oxo-dGDP phosphatase NUDT18
- NAD-capped RNA hydrolase NUDT12
- m7GpppN-mRNA hydrolase NUDT17
- NAD
- Bis
- Nucleotide triphosphate diphosphatase NUDT15
- Oxidized purine nucleoside triphosphate hydrolase
Sequence:
MERIDGVAVGLCAHSPYLRPFTLHYRQDGVQKSWDFMKTHDSVTILMFNSSRRSLVLVKQFRPAVYAGEVERHFPGSLTAVNQDQPQELQQALPGSAGVMVELCAGIVDQPGLSLEEAACKEAWEECGYRLVPTDLRRVATYMSGVGLTSSRQTMFYAEVTDAQRGGPGGGLAEEGELIEVIHLNLDDAQAFADNPDIPKTLGVIYAISWFFSQVVPHLSLQ
Protein: Carbamate kinase-like protein YahI (P77624)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Ornithine carbamoyltransferase subunit I
- Ornithine carbamoyltransferase subunit F
- NADP-specific glutamate dehydrogenase
- Carbamate kinase
- Uncharacterized protein YahG
- Glutamine synthetase
- Carbamate kinase-like protein YqeA
- Cyanate hydratase
- Glutaminase 1
- Glutaminase 2
Sequence:
MKELVVVAIGGNSIIKDNASQSIEHQAEAVKAVADTVLEMLASDYDIVLTHGNGPQVGLDLRRAEIAHKREGLPLTPLANCVADTQGGIGYLIQQALNNRLARHGEKKAVTVVTQVEVDKNDPGFAHPTKPIGAFFSDSQRDELQKANPDWCFVEDAGRGYRRVVASPEPKRIVEAPAIKALIQQGFVVIGAGGGGIPVVRTDAGDYQSVDAVIDKDLSTALLAREIHADILVITTGVEKVCIHFGKPQQQALDRVDIATMTRYMQEGHFPPGSMLPKIIASLTFLEQGGKEVIITTPECLPAALRGETGTHIIKT
Protein: Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) (Q9UJX3)
Organism: Homo sapiens (Human)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. APC7 is not required for the assembly of the APC/C complex, but has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates. Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18445686}. Nucleus {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Note=Localizes to spindle during metaphase and to cytoplasmic microtubules during interphase. {ECO:0000269|PubMed:18445686}.
Interaction partners:
- Fizzy-related protein homolog
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 1
- Cell division cycle protein 27 homolog
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Anaphase-promoting complex subunit 16
- Anaphase-promoting complex subunit 2
- Cell division cycle protein 23 homolog
- Anaphase-promoting complex subunit 4
- Cell division cycle protein 20 homolog
Sequence:
MNVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ
Protein: 60S ribosomal protein L37 (B5G0E5)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Interaction partners:
Sequence:
MTKGTSSFAKKRSKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSAKAKRRNTTGTGRMRHLKKVYRRFRNGFREGTTPKPKRAAVAASSSS
Protein: Transcriptional regulatory protein UME6 (Negative transcriptional regulator of IME2) (Regulator of inducer of meiosis protein 16) (Unscheduled meiotic gene expression protein 6) (P39001)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Binds to the URS1 site (5'-AGCCGCCGA-3') and recruits the RPD3 histone deacetylase complex to the promoters to negatively regulate the expression of many genes including CAR1 (arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism. Recruits also the ISW2 chromatin remodeling complex to promoters in a second gene repression pathway. Associates with the master regulator of meiosis IME1 in order to activate the expression of meiosis genes. Has both a positive and negative role in regulating phospholipid biosynthesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Histone deacetylase RPD3
- Transcriptional regulatory protein SIN3
- Meiosis-inducing protein 1
- Serine/threonine-protein kinase RIM11/MSD1
- Transcriptional regulatory protein SDS3
- Transcriptional regulatory protein RXT3
- Transcriptional regulatory protein UME1
- Histone deacetylase complex subunit CTI6
- Transcriptional regulatory protein RXT2
- Transcriptional regulatory protein PHO23
Sequence:
MLDKARSQSKHMDESNAAASLLSMETTANNHHYLHNKTSRATLMNSSQDGKKHAEDEVSDGANSRHPTISSASIESLKTTYDENPLLSIMKSTCAPNNTPVHTPSGSPSLKVQSGGDIKDDPKENDTTTTTNTTLQDRRDSDNAVHAAASPLAPSNTPSDPKSLCNGHVAQATDPQISGAIQPQYTATNEDVFPYSSTSTNSNTATTTIVAGAKKKIHLPPPQAPAVSSPGTTAAGSGAGTGSGIRSRTGSDLPLIITSANKNNGKTTNSPMSILSRNNSTNNNDNNSIQSSDSRESSNNNEIGGYLRGGTKRGGSPSNDSQVQHNVHDDQCAVGVAPRNFYFNKDREITDPNVKLDENESKINISFWLNSKYRDEAYSLNESSSNNASSNTDTPTNSRHANTSSSITSRNNFQHFRFNQIPSQPPTSASSFTSTNNNNPQRNNINRGEDPFATSSRPSTGFFYGDLPNRNNRNSPFHTNEQYIPPPPPKYINSKLDGLRSRLLLGPNSASSSTKLDDDLGTAAAVLSNMRSSPYRTHDKPISNVNDMNNTNALGVPASRPHSSSFPSKGVLRPILLRIHNSEQQPIFESNNSTAVFDEDQDQNQDLSPYHLNLNSKKVLDPTFESRTRQVTWNKNGKRIDRRLSAPEQQQQLEVPPLKKSRRSVGNARVASQTNSDYNSLGESSTSSAPSSPSLKASSGLAYTADYPNATSPDFAKSKGKNVKPKAKSKAKQSSKKRPNNTTSKSKANNSQESNNATSSTSQGTRSRTGCWICRLRKKKCTEERPHCFNCERLKLDCHYDAFKPDFVSDPKKKQMKLEEIKKKTKEAKRRAMKKK
Protein: HTH-type transcriptional regulator ClcR (A0A024HKB0)
Organism: Pseudomonas knackmussii (strain DSM 6978 / CCUG 54928 / LMG 23759 / B13)
Interaction partners:
- Aminoethylphosphonate catabolism associated LysR family transcriptional regulator
- Carbapenem-hydrolyzing beta-lactamase transcriptional activator
- HTH lysR-type domain-containing protein
- Uncharacterized HTH-type transcriptional regulator YeiE
Sequence:
MEFRQLRYFIAVAEEGNIGAAARRLHISQPPITRQIQALEQDLGVVLFERTHRGVELTAAGTTFLEDARRLLHVTEISRVRSRAASRGEIGELRVAYFGTVVLHTLPLLLRQLLSVAPSATVSLTQMSKNRQIEALDAGTIDIGFGRFYPYQEGVVVRNVTNERLFLGAQKSRARSFGEQVHCSALRNEPLILFPREGRPSFADEVIGVFKNARVEPKVVAIVEDVNAAMALALAGVGVTIVPETVAMISWPDFGFTELVGSKATVPVSCIYRHDHIAPILKTFLNLLPIRESQ
Protein: very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Q9VZL3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
- Very-long-chain
- Very-long-chain
- RH59310p)
- Elongation of very long chain fatty acids protein
- Elongation of very long chain fatty acids protein
- Elongation of very long chain fatty acids protein
- Elongation of very long chain fatty acids protein
- HDC11342
- Peptidoglycan-recognition protein SC2
- Mediator of RNA polymerase II transcription subunit 20
Sequence:
MELEILNAKNSKPYGKVKVPSGATPIGDLRALIHKTLKQTPHANRQSLRLELKGKSLKDTDTLESLSLRSGDKIYVKDLGPQIGWKTVFLAEYAGPLIVYLIFYFRPELVYGKAASLPISLTTHIAAGCYTVHYVKRLLETIFVHRFSHATMPLRNLFKNCTYYWGFTAYVSYHVNHPQFTSPCMCTVWGALGAFALCELGNFSVHIALRNLRPPGTKVRKIPVADGNPLTKLFDLVSCPNYTYEIGAWVSFSVLTSCLAAYLFAFAGAFQMTIWALAKHRNYKKEFKDYPRQRRSIFPFVL
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit) (Q02365)
Organism: Bos taurus (Bovine)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:18721790}; Single-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
Sequence:
MAHGHGHEHGPSKMELPDYKQWKIEGTPLETVQEKLAARGLRDPWGRNEAWRYMGGFANNVSFVGALLKGFKWGFAAFVVAIGAEYYLESQKKDKKHH
Protein: ORF75 (D0UZU4)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Subcellular location: Virion tegument {ECO:0000256|ARBA:ARBA00004535}.
Interaction partners:
Sequence:
MAYDVTGLWLESDLTADEEAFVSFYTSRTGTLTLVPGGTGGYYLLWITFRRPPTSREERERRDVEIQTVLAVLSPLLGYPHVIRRSPPRGSERVVSFGYGPNINHRPTTLSTELGVLLRELGLQEWARVEVGRHLVSKITQTLLEPHPPQFIRAFTQNTDLVPYEGLEVPEGPQPVARPHIEDDVIMQAVMISLGADLLPLAVQASTGDNYNVARYFVIPGRCTMERWPWNCARQAFGIHGAYTHVHSSVQRGIRGLGNLLFHSTLFPGGQTQGALTGLYATEPALGPRAHSRFRRIFAKGVQQAEMLQGAGVPTLGGFLKTVRTIATTPGNALAVCSISTTTSKECISLRRMIPQQTVVCLGRFEPTDGPDTYPNLYRDSSDNAVRILETLKLVQRLAKGPIFSGLNRSHDPAPVVRHLQALAPRTGLELFVSKLPDEVRAHLPADPAAGPDAVEAAVAEHFLNVYCSLVFAVVAESGAVPGDLGETPLEVLQRAARLCACQITVLGRTSEQPGIRIVDDLTGETTRVFSVDQPSSTPPSPWLALSDGVRVSGHPEDVDWGLFATGSTIHQLLRHATVGSKEFFTRHMDRCSNGLIAQQAGVGPLDIPVSDYHLVLHSSMLAERVAPRVPDTVEAITPSMANLLHKDFETWVKALPQELLPVPAWRGQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKLQDVVLTGAVAWSPEDHQAGLLQECLFACKEFCRELGVALSISSAASSPTLSERHVRITQQQETVEVLPFNSVVFTSWAEVKGSRYRVTPDVKVEGNALVYLAVNQSCLIAGSTFEHNFLASRHPIPPLNPSTVASLFMLVKYLMSKRLIVSGHDIGDGGLLPSAIEMALAGCRGLQLSLPAHPNPLELMVSETPGALVEVPQVHLSEVLRAARDYRCVAHPLGTVGPEGQGNNVTVLQNETVVFQETLTSLQVSWTSFSDEMWNLVTPPLHPLEDMHRKDLGRLEHHLGSLRAMCLGSQLRLFSCPTSPRRVAALVLPGSSAPYALMAALQNTGFEVATVTVEELKRGQSLSGFSGLITCLRTGCQASYASARGWVLALCNDPTCASTLTEFLNRPDTFSICCGEVGFQLLVALGVVGRSESSPYTYGPTPPQRWAVNLETNVSKLYDSHWLNIQIPQNTKSVFLRVLRGTVLPSWAQGEYLGVRYEQDALEYILRQRGEITLTYHGNAADETLPARHYPRNPTGNSTVAGLTSSDGRHAALIIDPSLMFHPWQWQHVPPDLTPLSMSPWAMAFQSIYLWSVKKINDHH
Protein: Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT) (P49364)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: The glycine cleavage system catalyzes the degradation of glycine.
Subcellular location: Mitochondrion.
Interaction partners:
Sequence:
MRGGLWQLGQSITRRLANGGDKKAVARRCFATESELKKTVLYDFHVAHGGKMVPFAGWSMPIQYKDSIMDSTLNCRQNGSLFDVSHMCGLSLKGKDVVSFLEKLVIADVAALAHGTGTLTVFTNEKGGAIDDSVITKVTDDHLYLVVNAGCRDKDLAHIEEHMKAFKAKGGDVSWHIHDERSLLALQGPLAAPVLQHLTKEDLSKLYFGEFRVLDINGSQCFLTRTGYTGEDGFEISVPSEHGVELAKALLEKSEGKIRLTGLGARDSLRLEAGLCLYGNDLEQHITPIEAGLTWAIGKRRRAEGGFLGADVILKQLADGPSIRRVGFISSGPPPRSHSEIQDEGGNNIGEVTSGGFSPCLKKNIAIGYVKSGLHKAGTKVKIIIRGKQNEGVVTKMPFVPTKYYKPS
Protein: Trafficking protein particle complex subunit 2-like protein (A0A0B4J286)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
Interaction partners:
Sequence:
MAVCIAVIAKENYPLYIRSTPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDNMVTSMMIQVC