wanglab/gogpt-training-data huggingface dataset:
Protein: ELAV-like protein 2 (Elav like-1) (Xel-1) (Protein ElrB) (p45) (Q91903)
Organism: Xenopus laevis (African clawed frog)
Function: Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Required for the vegetal localization of vg1 mRNA. Probably required for nervous system development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16199879, ECO:0000269|PubMed:9174163}. Cytoplasm, cell cortex {ECO:0000269|PubMed:16199879, ECO:0000269|PubMed:9174163}. Note=Enriched at the vegetal cortex in stage III and IV oocytes. Shows both nuclear and cytoplasmic localization in the neural tube at the neurula stage, although endogenous elavl2 is not expressed at this stage. {ECO:0000269|PubMed:16199879, ECO:0000269|PubMed:9174163}.
Interaction partners:
Sequence:
MAVRLCDVASLLRSGSWAAEPWTGQVIAAMETQLSNGPTCNNTANCPNTINCSSPVESNNTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITEGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKVNHTILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGGIKSRFSPMAIDGMTSLAGINFPGHAGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTSKTHKA
Protein: Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) (Q91XM9)
Organism: Mus musculus (Mouse)
Function: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.
Subcellular location: Cell membrane {ECO:0000305|PubMed:11997254}; Lipid-anchor {ECO:0000250|UniProtKB:Q63622}. Postsynaptic density {ECO:0000250|UniProtKB:Q63622}. Synapse {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:Q63622}. Cell projection, axon {ECO:0000250|UniProtKB:Q63622}. Perikaryon {ECO:0000250|UniProtKB:Q63622}. Note=Concentrated in soma and postsynaptic density of a subset of neurons. {ECO:0000250|UniProtKB:Q63622}.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 2B
- Disks large homolog 3
- Disks large homolog 4
- Disks large homolog 1
- Disks large-associated protein 1
- Disintegrin and metalloproteinase domain-containing protein 22
- SH3 and multiple ankyrin repeat domains protein 3
- Glutamate receptor ionotropic, NMDA 1
- Ras/Rap GTPase-activating protein SynGAP
Sequence:
MFFACYCALRTNVKKYRYQDEDGPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLGEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDSDMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
Protein: Bone morphogenetic protein-10 (Q70GM8)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
LSEQDGVDFNTLLQNMKNEFLKTLNLSDIPLHESAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLASHPVGVIGVRKYPLLFNVSIPHHEEITMAELRLYTLVERDQMLYEGLDRKVTIFEVLENDHMGVGEERKIVALASRQIYGTSSEWESFEVTEAIRRWRRAGLTTHRLEVHIESREGEEQNGEGKLDIDINSEAKHVPLLIVFSDDQSNDQKEEKQELNEMIDHEQLLDLENLEVGNFHGHPGEEALLQMRSNIIYDSTARIRRNAKGNYCKKTPLYIDFKEIGWDSWIIAPAGYEAYECHGVCAYPLTEHVTPTKHAIVQTLVHLKNPQKASKACCVPTKLDPISILYMDAGVVTYKFKYEGMVVSECGCR
Protein: Nuclear receptor coactivator (A0A0G2JZG4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR038181}.
Interaction partners:
Sequence:
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLGTENQEACQRYEVMQCFTVSQPKSIQEDGEGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRINPSVNPGISPAHGVTRSSTLPPSNNNMVSARANRQQSTDLNSGSSHSNSSSSQGSFGCSPGNQIVASVALSQGQAGSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQANSGLATRARMSNNSFPPNIPTLSSPVGITSGACSNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMSSQNSPSRLSMQPAKAESKDNKEIASILNEMIQSDNSANEGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPEKKDSASASTAMSVSGQAQGSASIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPAPVTKPAPEEVKLESQSQFSADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVPGVNIKSEILPASLQPTPARSAPRLNRLPELELEAIDNQFGQPGAGDQIPWANNTVTAINQSKPEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLMMEDRPTLYPQPYSSPSPTAGLSGPFQGMVRQKPSLGTMPVQVTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAANAPVGMNMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQIIQQQRAMLMRHQSFGNNIPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLATRSSMVNRGMAGNMGGQFGTGISPQMQQNVFQYPGSGLVPQAEANFAPSLSPGSSMVPMPIPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNNMSITVSMAGGNANVQNMNPMMGQMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDLLKTEADGNQVSKKENPSAELADKGASKPTLVLAVLLQAIRTNADEEHGLKTSRKKPFPQVLPSASHRPWYKQLHKNSIYSETTGL
Protein: Sensory box protein (Q9A9A8)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- diguanylate cyclase
- diguanylate cyclase
- Response regulator PleD
Sequence:
MQGLRAYWGIAVLSLDPRRLLGLAFASADLLVELQNGRVRLALGAAQKVMGASEAALAGKAWAELFHADDRALMEAMLSCADDGVRRGPVVLRLAEPADKHIRVVLRALPENQGRISAAVTAAQPAGPPLSASSLQPRESFDDIAQGLFEAARVTGIELELAMVEFAGLGDMREALSPDEAVALDVRVASALRAEAHGGAAATKLSDDRFALLRQRDDRPENMIKRLTKMVSAEASAHVVPLENGGGSSRALRALRYALDDFLREGLKETPPMTLSEAMNRSVKRTLARAGALGVAVSQRRFNLAFQPVVSLSTGLAHHHEVLVRFEDGGSPFALIRMAEEFDLIEELDHAIVEQAVKKLANDSERKLKLAVNVSGQTIGNETFVEHVGRLLAKFNEAKGRLIFEITETRAIDNLATANQHIQSLRSMGSLVCLDDFGAGSSSFSYLQQLALDIVKIDGRYVRELADNSRDGALVRRLVELCRDLKVRTVAEMVETSEVEDVIRSVGVDFAQGWLYGKPADKPLPALRPAAPVKAVARRAGASDSWG
Protein: Glycoprotein G (O89343)
Organism: Hendra virus (isolate Horse/Autralia/Hendra/1994)
Function: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of glycoprotein G to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).
Subcellular location: Virion membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Host cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MMADSKLVSLNNNLSGKIKDQGKVIKNYYGTMDIKKINDGLLDSKILGAFNTVIALLGSIIIIVMNIMIIQNYTRTTDNQALIKESLQSVQQQIKALTDKIGTEIGPKVSLIDTSSTITIPANIGLLGSKISQSTSSINENVNDKCKFTLPPLKIHECNISCPNPLPFREYRPISQGVSDLVGLPNQICLQKTTSTILKPRLISYTLPINTREGVCITDPLLAVDNGFFAYSHLEKIGSCTRGIAKQRIIGVGEVLDRGDKVPSMFMTNVWTPPNPSTIHHCSSTYHEDFYYTLCAVSHVGDPILNSTSWTESLSLIRLAVRPKSDSGDYNQKYIAITKVERGKYDKVMPYGPSGIKQGDTLYFPAVGFLPRTEFQYNDSNCPIIHCKYSKAENCRLSMGVNSKSHYILRSGLLKYNLSLGGDIILQFIEIADNRLTIGSPSKIYNSLGQPVFYQASYSWDTMIKLGDVDTVDPLRVQWRNNSVISRPGQSQCPRFNVCPEVCWEGTYNDAFLIDRLNWVSAGVYLNSNQTAENPVFAVFKDNEILYQVPLAEDDTNAQKTITDCFLLENVIWCISLVEIYDTGDSVIRPKLFAVKIPAQCSES
Protein: Monocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter) (P36021)
Organism: Homo sapiens (Human)
Function: Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20628049, ECO:0000269|PubMed:23550058, ECO:0000269|PubMed:25527620, ECO:0000269|PubMed:26426690}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Solute carrier organic anion transporter family member 1C1
- Monocarboxylate transporter 10
- Type II iodothyronine deiodinase
- Large neutral amino acids transporter small subunit 2
- Thyroxine 5-deiodinase
- Pro-thyrotropin-releasing hormone
- Solute carrier organic anion transporter family member 4A1
- Solute carrier organic anion transporter family member 1A2
- Solute carrier organic anion transporter family member 1B1
- Small ribosomal subunit protein eS4, Y isoform 1
Sequence:
MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKMLAPDPDPNGELLPGSPNPEEPI
Protein: TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83) (Q9BUZ4)
Organism: Homo sapiens (Human)
Function: Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:32268273}. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton {ECO:0000305}.
Interaction partners:
- Neutrophil cytosol factor 1
- Transforming growth factor beta-1-induced transcript 1 protein
- Nucleotide-binding oligomerization domain-containing protein 2
- Platelet glycoprotein Ib beta chain
- TNF receptor-associated factor 6
- 5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial
- Interleukin-17 receptor A
- Tumor necrosis factor receptor superfamily member 16
- LIM and SH3 domain protein 1
- Receptor-interacting serine/threonine-protein kinase 2
Sequence:
MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
Protein: Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Cell growth-inhibiting gene 1 protein) (Lysosomal pepstatin-insensitive protease) (LPIC) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I) (O14773)
Organism: Homo sapiens (Human)
Function: Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
Subcellular location: Lysosome {ECO:0000269|PubMed:19941651}. Melanosome {ECO:0000269|PubMed:12643545}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}.
Interaction partners:
- Protection of telomeres protein 1
- TERF1-interacting nuclear factor 2
- Telomeric repeat-binding factor 1
- Palmitoyl-protein thioesterase 1
- Friend leukemia integration 1 transcription factor
- Battenin
- Nuclear protein 2
- DnaJ homolog subfamily C member 5
- Ceroid-lipofuscinosis neuronal protein 6
- Bis
Sequence:
MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP
Protein: Peroxisomal membrane protein PEX13 (Peroxin-13) (A0A1D8PTW0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00046271}.
Interaction partners:
- Peroxisomal membrane protein PEX14
- Pex19p
- Peroxisomal targeting signal receptor
- Peroxisome assembly protein 12
- Peroxin-7
- Peroxin-3
- Pex11p
- Oleate-induced peroxisomal protein POX18
- Oleate-induced peroxisomal protein POX18
- Peroxisomal ATPase PEX6
Sequence:
MSSSQPRTKPWEVSQGKSAASTTEPLTSNIPPSSLSNSSTTATAQGQPQSQIQPPSVPELPTSLSSDLNTMAESSPYGGYGNSSMNRYGTTGGYGSSMYGGGYGSSMYGNSMYGGGYGSSMYGGGYGGYGSGYGGYGSYGSGMYGGGMYGNNPSMMGQGGLGEGTQATFQLIESIIGAVGGFAQMLEATYMATHSSFFTMVNLAEQFGNLKNALGSILGIFALIKFVKKIFYKITGRVYNYGINASEFTKFEKNQKKLEENLRRNQSGQKPRISLKPLVLFLVAAVGFPYLLSKAIKLIEEKNQRPPPVPSKIQFARALYEFNPQNPQVEAPLEPKEIVAILDSRDNWLRIRKRSGTMGWVPSNYVEVIDT
Protein: Hexose transporter (Q26765)
Organism: Trypanosoma brucei
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MTERRDNVSHAPDAIEGPNDGAHAEDTSPGFFSFENLGVAQVQVVGGTLNGYVIGYVAVYLLLYLTATECKFTTEGACGGAKIYGCKWSGTTCKFENPKCSEGSDPSDSCKNEVAYTSVYSGIFACAMIVGSMVGSIIAGKCITTFGLKKSFIIVSITCTIACVVVQVAIEYNNYYALCTGRVLIGLGVGILCSVCPMYVNENAHPKLCKMDGVLFQVFTTLGIMLAAMLGLILDKTGASKEEANMAGRLHVFSAVPLGLSVAMFLVGMFLRESTATFAQDDDGKADGGMDPNEYGWGQMLWPLFMGAVTAGTLQLTGINAVMNYAPKITENLGMDPSLGNFLVMAWNFVTSLVAIPLASRFTMRQMFITCSFVASCMCLFLCGIPVFPGVAGKEVKNGVATTGIALFIAAFEFGVGSCFFVLAQDLFPPSFRPKGGSFVVMMQFIFNILINLLYPITTEAISGGPTANQDKGQAVAFILFGLIGLICSVLQFFYLYPYDANQDHENDHGGEPVEQKTYPVEASPRN
Protein: Carnosine N-methyltransferase (EC 2.1.1.22) (F1N9S8)
Organism: Gallus gallus (Chicken)
Function: N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5BJZ6}. Nucleus {ECO:0000250|UniProtKB:Q5BJZ6}.
Interaction partners:
- Carnosine synthase 1
- M20_dimer domain-containing protein.
- Carnosine dipeptidase 1
- Carnosine N-methyltransferase 2
- Aldehyde dehydrogenase 1A1
Sequence:
MSAACAVSREAQPALPPPPRGDRDPPAKAMRRGLRRGREEEQDQERLPWPAESGGGDPEGEQEAWRSGERRRRQPQEPRALAAAARVEEEAEEERMEREHFRRIINAFRYYGTNMHERVNRTERQFKSLPANQQSLLPQFLPHLDKIRKCIDHNQEILQTIVNDCVHMFENKEYGEDGGGKITPASTFDMDKLKSTLKQFVRDWSEEGKPERDSCYQPIISEIVKNFPKERWDFSKVNILVPGAGLGRLAWEIAMLGYACQGNEWSLFMLFSSNFVLNRCSEVNSCKLYPWIHQFSNNKRSADQIRPIYFPDVDPHSLPSGSNFSMTAGDFQEIYSECNTWDCIATCFFIDTAHNVIDYIDTIWKILKPGGIWINVGPLLYHFENLANELSIELSYEDIKNVILQYGFHIEVEKESVLSTYTVNELSMMKYYYECVLFVVRKPEEKCFE
Protein: 3-dehydrosphinganine reductase TSC10B (EC 1.1.1.102) (3-ketodihydrosphingosine reductase) (KDS reductase) (3-ketosphinganine reductase) (F4JZN6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). Required for sphingolipid biosynthesis. In plants, sphingolipids seems to play a critical role in mineral ion homeostasis, most likely through their involvement in the ion transport functionalities of membrane systems in the root. Is stereospecific for D-erythro-DHS production and does not produce L-threo-DHS.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:21421810}; Multi-pass membrane protein {ECO:0000305|PubMed:21421810}.
Interaction partners:
- Long chain base biosynthesis protein 1
- serine C-palmitoyltransferase
- Long chain base biosynthesis protein 2b
- Long chain base biosynthesis protein 2a
- Sphinganine C4-monooxygenase 1
- Sphinganine C4-monooxygenase 2
- Alkaline ceramidase
- Sphingosine kinase 2
- Neutral ceramidase 1
- Sphingosine kinase 1
Sequence:
MAAIFSLFLFFILFIVSLLIILSFIVRPRSVTIPIKFRHVFITGGSSGIGLALAHRAVSEGAKVSILARSTEKLAEAKRSIQLATGVEVATFSADVRDYDAVSKAIDESGPIDVLIVNQGVFIGKELEKQSPEEVKFMIDVNLTGSFNVIKAALPAMKAREGRGPASISLVSSQAGQAGIYGYTAYSASKFGLQGLAQALQQEVISDGIHVTLLFPPDTDTPGFEQELKKRPELTSIIAASSGSMKTNEVAKICFDGIKAGKFTVTCHFIGFLLSIASTGMSPQGSFWLALTEVMFGGLIRLASLVFQWQWYKTIEKWSQRNKKEVNSKLA
Protein: alpha,alpha-trehalase (EC 3.2.1.28) (G8BDA6)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- Trehalase
- Uncharacterized protein
- Glycerol-1-phosphatase
- Trehalose-6-phosphate synthase
- Glycosyl hydrolase family 13 catalytic domain-containing protein
- Glycosyl hydrolase family 13 catalytic domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- 1,4-alpha-glucan-branching enzyme
Sequence:
MDIENNGIYMENSSRIKGIRRLFKDNKTYIIAMTIIANFILFYSLHLLNTRFSEAFPFVLPRAEKYTLEQTSDSNLGDFVNSFENKEIFSQVQFSEHAFYDRKMNVVGTIEYSKYNQFQKQPYVANGYIGSRIPNLGHGFTYDQLTESPDSKKDDLYNGWPLFDKRFSGAFIAGFYDLQENTTGNNFPELLKNGYESVISAIPQWTTLKLAIQHGDKRYTLDPASPDGVGQITNYVQNMSLSTGIVTTQFTWLESLDVRYTVLAHRSEINLGLVKVDIKNKGNDTVEIDVIDELNFDTAQRCSLNLIGHDNSGIYVSFSPDNLDYISGAIYSTLHLDSVKRHSKNKKTNQTSSIRLHAQDSTQFGKTVGIVSTDLDPSKFKNSRDTLEFAKKVSQKFEYLDLVIKSHVRAWKELMGKQSTITFPNDPLLDLGSKASVYHLLANTRPDAQGLTGALGVAGLSSDSYGGMVFWDTDFWMFRAILALDPTHAKSIVNYRMHTHQQALKNTPQGYEGAAYPWTSGRFGNCTATGPCLNYEYHINSAIAMAAWELYISGAVDDQYLESTVYPLISDAAKFYADYVTSYNETIDKFITSNLTDPDEYANHVDNGAYTNAGIALLMNWINDIGDILGIKMPEIYTDISQKMYLPTADNSQNITLEYSGMNSSVGIKQADVVLMTYPLQNSLVDDEQAYINMEFYSGKQVSYGPAMTFSIFSIVAANLATSGCASQSYLHKAMQPYLRGPFAQFSEQNNDNFKTNGGTHPAYPFLTAHGGFIQAVVNGLTGLRHSYTIDNGKIRRSLFLDPIALPCLGDGVQYSGIHYDNHTISMNITGSTFVIRNEGKTNKRANDYISITIADRNPGRGTYKLKDNEEKSFKLYQPSKIFEDSVSECGLATFYNITESAPGDSSFSINDGDNTTRWQVKYNDTTGKVLIDLHSIKNITGVVFNWADKPPKKVKLSKYMGTKFKDVTDFLAKVDFGNYVYKNYRFANPGEKLLNQSEVFENVYSDDVTINAPFSSKELEEVIVPVRHNTTSWNINLQGRFLLLEVDGIHNTIPIEDDYGGAKLAEVNFF
Protein: RNA-binding protein, putative (Q389D4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- FHA domain-containing protein
- PHD finger-like domain-containing protein 5A
- Splicing factor 3B subunit 1, putative
- Spliceosome-associated protein, putative
- Cell division control protein, putative
- Uncharacterized protein
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor U5-Cwc21
- Uncharacterized protein
- RNA helicase
Sequence:
MPPRARLFVGQLNFDATEDDIYALFDFYGKALHVNILRDKETQKSKGSAFVEYGSTEEADCAILALHNRYNMEREKPLQVSYCNKSELISEFGRDHASKLHDENPANPAPPQRVQR
Protein: Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Q803L1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, cilium, flagellum {ECO:0000256|ARBA:ARBA00004230}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000256|ARBA:ARBA00004218}.
Interaction partners:
Sequence:
MQSRNHLYRTLATRGQHLPCKLHGATVLSARTYADKAAIDADVTVVGSGPGGYVAAIKAAQLGFKTVCVEKNATLGGTCLNVGCIPSKALLNNSYLYHMAHGKDFESRGIEIQGISLNLEKMMAQKSGAVKALTGGIAHLFKQNKVTHVNGFGTITGKNQVTAKTADGEQVINTKNILIATGSEVTPFPGIEIDEDSVVSSTGALSLKNVPEELIVIGAGVIGVELGSVWQRLGAKVTAVEFLGHVGGMGIDMEISKNFQRILQKQGLKFKLSTKVMGATKRPDGKIDVAVEAAAGGKNETLTCDVLLVCIGRRPFTGNLGLESVGIELDKRGRIPVNGRFQTNVPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKTEEQLKEEGVPYKVGKFPFAANSRAKTNADTDGLVKILSHKDTDRMLGAHILGSGAGEMINEAALAMEYGASCEDVARVCHAHPTVSEAFREANLAASFGKAINF
Protein: SR-CI (Q5ELU8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEFFWTLAVIVIYCIGHIHGRCERSLDLDNGSINYRPRNIVRFRCNRGYTLQGIVMQTCDRDGRLRGEKPFCASRGCAKPEDPENGHVENLSLRADVVCHDGYVLVGGRTAYCDGERWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFSTTTEPTAPTGSNEQPLVYDMMSCSGRCGTSMSASNITNNGIVMGCGCNDECLSDETCCLNYLEECTKELLTTTEDDISSLPPTVTSISTSTTRKSTTTTTTSTTTTSTTTTKRPTTTTTTTKATTTKRTTTTKKPTTTSTTPKPTTTTSTTPKSTTSTTFTTSTTSTRPTTTTTINVFTTKKTTIMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIEGHMDTSGSTPNPALVVLYLLLAIVLVVVLANVVNRWIIPITGSKTSSEKAVRFKKAFDSLRKQRKRNSMDDQPLCDSDNDDVEYFEEMGVDIRHRTDL
Protein: GCN5-related N-acetyltransferase 10, chloroplastic (EC 2.3.1.255) (EC 2.3.1.48) (Q9C7G6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:32633465}.
Interaction partners:
- Acyl-CoA N-acyltransferases
- GCN5-related N-acetyltransferase 7, chloroplastic
- GCN5-related N-acetyltransferase 1, chloroplastic
- GCN5-related N-acetyltransferase 4, chloroplastic
- GCN5-related N-acetyltransferase 5, chloroplastic
- GCN5-related N-acetyltransferase 9
- GCN5-related N-acetyltransferase 8
- N-terminal acetyltransferase B complex catalytic subunit NAA20
- GCN5-related N-acetyltransferase 2, chloroplastic
- N-terminal acetyltransferase A complex catalytic subunit NAA10
Sequence:
MGHLPQSLYSAAGPKFPYPGSSGLGVDQRKLTWSRFPVFLRCASTESLTSLTQNNAAEIELKYLVSQHGWDVRRLNRDDEDEIRRVSLVQAEAFHIPLALFDDFFFMFFQAEVLSALLYKLKNSPPDRYACLVAEQTSETETLSSSSVVGVVDVTAQTESSVLRYFPGVEEYLYVSGLAVSKSQRRKKMASTLLKACDVLCYLWGFKLLALRAYEDDAAARNLYSNAGYSVVETDPLWTSTWIGRKRRVLMSKRFS