wanglab/gogpt-training-data huggingface dataset:
Protein: Lytic switch protein BZLF1 (EB1) (Protein Z) (Trans-activator protein BZLF1) (Zta) (bZIP transcription factor ZEBRA) (P03206)
Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Function: Transcription factor that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle (Probable). Mediates the switch from the latent to the lytic cycle of infection in cells containing a highly methylated viral genome. Probably binds to silenced chromatin and recruits host chromatin-remodeling enzymes. Regulates this switch by binding to 2 types of ZEBRA response elements (ZREs): the CpG-free AP-1 like elements (latency) and the methylated CpG-containing elements (lytic replication) (Probable). Activates preferentially the methylated forms of the viral lytic R (BRLF1) and Na (BRRF1) gene promoters, the latters being the first genes activated during Z-mediated reactivation in latently infected cells. BZLF1 and BRLF1 act together to trigger lytic replication. Also binds the lytic origin of replication, oriLyt. Induces G1 cell cycle arrest by stabilizing the host CCAAT/enhancer binding protein CEBPA. This function is important because the lytic cycle preferentially takes place in host cells arrested in G1.
Subcellular location: Host nucleus {ECO:0000269|PubMed:10849009, ECO:0000269|PubMed:8380464}.
Interaction partners:
Sequence:
MMDPNSTSEDVKFTPDPYQVPFVQAFDQATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAPQPGDNSTVQTAAAVVFACPGANQGQQLADIGVPQPAPVAAPARRTRKPQQPESLEECDSELEIKRYKNRVASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDLLNF
Protein: CTR9 homolog, Paf1/RNA polymerase II complex component (RNA polymerase-associated protein CTR9 homolog) (A3KDM3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- RNA polymerase-associated protein LEO1
- Parafibromin
- RTF1 homolog, Paf1/RNA polymerase II complex component.
- RNA polymerase II-associated factor 1 homolog
- Superkiller complex protein 8
- Transcription elongation factor SPT5
- FACT complex subunit
- Transcription elongation factor SPT6
- Transcription elongation factor SPT4
- FACT complex subunit SSRP1
Sequence:
MSRGSIEIPLRDTDEVIELDFDQLPEGDEVISILKQEHTQLHIWIALALEYYKQGKTEDFVKLLEAARIDGNLDYRDHEKDQMTCLDTLAAYYVQQARKEKNKDAKKDLINQSTLLYTMADKIIMYDQNHLLGRACFCLLEGDKMDQADAQFQFVLNQSTNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFGRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSTFVLPFFGLGQMYVYRRDKENAAQCFEKVLKAYPNNYETMKILGSLYATSDDQEKRDIAKEHLKKVTVQYSDDVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNLGALHFRLGNLGEAKKYFLASLERAKAEGEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQNDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDSKNLYAANGIGAVLAHKGYFREARDVFAQVREATAEISDVWLNLAHIYVEQKQYISAVQMYENCLKKFYKYQNTEVLLYLARALFKCGKLQECKQTLLRARHVAPNDTVLMFNVALVLQRLATLVLKDEKSNLKAVLSAVKELELAHRYFSYLSKSGDKMRFDLALAASEARQCSDLLSQAQYHVARARKQDEEEKEHRAKQEQERDLLRQQIMKEQEERKSREAEEQKKLLEQRAQYVERTRNLLNFEGMKEASKDKKKGGGGRRKKGGDFDEFVNDDSDEDLPIKKKKKRRTESGSEVEDGGEEGEKKPRNKKRRRPNKREDDGSDDEEGGSRPKKQRKPRERKKIEKPKPERMPPSLKGKIKSKAIISSSDSSSDEDGLKIAEDRNARDSGSGSDDEEAPRKRIVSDSDSNEDRNQSGSEAGSPPQRSANSDDESGSERPVKRRRPRPQSDSEQSDNESKKSRSDASDDESPAGSPAAAASDRGSENEGSPQRSDNDSGSNNEASNRGSDEDSD
Protein: Uncharacterized protein (Q38AX0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSETVAIQTLLEAFEESSERINALYNKVKSAGDDCKERATTIDVFRVLHDCFVFHTDTLQNQIDALKTYEEQEAENIEEEVEELEKELHLLDRISRGCDDAGCPLPSVNDVSLAAYQAFVTRSVDLSAQLSVMLEGLRHILTLTPPRLSKAQSIVTWLGVANKATWSAKEKQLNASWKSLEEDARLASASMDEPSLVAVRQLLSDVMQLGKKAVSAVGSGSRAETERARDVEHLGSQQRRLVLWCRQQQANLDVLTEPDHIQEFCKSLLEHYNVMSDNYHVVLEKAEPYMDNETVQEWLLEASEAWLHLQVKALEQFRRTLFEVHQDSLLEDQVEGQSAFCLQLGTVLGALECTLTPWCEVRSSACGRCIQLLDSCRELRGMMPEYEKLSRQLLELTDRLRIDREAYDCYRAAALSHVTYLSSSAELLAEAARRKGEYKACVYELQEWAVKKVRCDSWRNIRDKVRDIKDLLEQDQLLQRHRGEPV
Protein: Cytochrome b-c1 complex subunit Rieske-1, mitochondrial (EC 7.1.1.8) (Complex III subunit 5-1) (Rieske iron-sulfur protein 1) (RISP1) (Ubiquinol-cytochrome c reductase iron-sulfur subunit 1) (P49729)
Organism: Nicotiana tabacum (Common tobacco)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P08067}; Single-pass membrane protein {ECO:0000250|UniProtKB:P08067}.
Interaction partners:
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 3
- Cytochrome b-c1 complex subunit 7
- Cytochrome b-c1 complex subunit 7
- Cytochrome c1-2, heme protein
- Cytochrome c1-2, heme protein
- Cytochrome c1-1, heme protein
- Cytochrome c1-2, heme protein, mitochondrial-like
- Cytochrome c1-2, heme protein
- Cytochrome c1-1, heme protein
Sequence:
WPVRSAAPSSSAFISANHFSSDDDSSSPRSISPSLASVFLHHTRGFSSNSVSPAHDMGLVPDLPPTVAAIKNPTSKIVYDEHNHERYPPGDPSKRAFAYFVLTGGRFVYASLMRLLILKFVLSMSASKDVLALASLEVDLSSIEPGTTVTVKWRGKPVFIRRRTEDDISLANSVDLGSLRDPQQDAERVKNPEWLVVIGVCTHLGCIPLPNAGDFGGWFCPCHGSHYDISGRIRKGPAPYNLEVPTYSFLEENKLLIG
Protein: Cilia- and flagella-associated protein 52 (E1BKF9)
Organism: Bos taurus (Bovine)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Important for proper ciliary and flagellar beating. May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11. May play a role in cell growth and/or survival (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}. Cytoplasm {ECO:0000250|UniProtKB:Q8N1V2}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8N1V2}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37327785}. Note=Located in the proximal region of respiratory cilia. {ECO:0000250|UniProtKB:Q8N1V2}.
Interaction partners:
- EF-hand domain-containing protein 1
- Parkin coregulated gene protein
- Tektin-1
- Cilia and flagella associated protein 45.
- Tektin-4
- Methyl-CpG-binding domain protein 1
- Tektin-3
- Protein Flattop
- EF-hand domain-containing family member C2
- Outer dynein arm-docking complex subunit 1
Sequence:
METQASPKDEVAEAVELELEAVIGFNGHVPTGLKCHPDQEHLVYPLGCTILIQAINTQEQNFLHGHGNNVSCVAISKSGLYIASGQVTFMGFKADIILWDYKKRELMARLSLHKGKIEALAFSPNDMYLVSLGGPDDGSVVVWSIAKREAICGSPAAGLNVGNATTVIFSKCRDEMFVTAGNGTIRVWELDLPNRKIWPTECQTGQMKRIVMSISMANDDSFFYLGTTTGDILKMNPRTKLLADTGPAKDKFSLGVSAICCLKMGGLLVGSGDGLLVFCKSPSYKPIKKIQLQGGITSITLRGEGHQFFVGTEESHIYRVNFTNFKETLITTCHFESVEDIVFPFGTAELFATCAKKDIRVWHTLTNRELLRITVPNMTCHGIDFMRDGKSIISAWDDGRIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWHIGHQTQKLEEALKEHKSSVSCIRVKKSNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELDGSLSGAVNGMDITVEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPFPS
Protein: Argonaute (Plant)-Like protein (G5ED77)
Organism: Caenorhabditis elegans
Interaction partners:
- Sperm-specific class P protein 16
- DRBM domain-containing protein
- Endoribonuclease dcr-1
- RNA-directed RNA polymerase
- Small RNA 2'-O-methyltransferase
- PAZ domain-containing protein
- Putative protein tag-76
- Protein-tyrosine phosphatase
- Sodium/potassium-transporting ATPase subunit alpha
- Domain of unknown function WSN domain-containing protein
Sequence:
MSRRNATNFVDNNTLTSSGISGSGSLSPPITSRPASGQASPLSSNGSLSPPVDDQGSVSYNSDSPRDLSPLLLSELACLNMREVVARPGLGTIGRKIPVKSNFFAVDLKNPKMVVVQYHVEVHHPGCRKLDKDEMRIIFWKAVSDHPNIFHNKFALAYDGAHQLYTVARLEFPDDQGSVRLDCEATLPKDNRDRTRCAISIQNVGPVLLEMQRTRTNNLDERVLTPIQILDIICRQSLTCPLLKNSANFYTWKSSCYRIPTAAGQALDLEGGKEMWTGFFSSAHIASNYRPLLNIDVAHTAFYKTRITVLQFMCDVLNERTSKPNRNNPRGPGAPGGYRGGRGGARGGSYQNFGNRGPPGANVRDDFGGNGLTFTMDTLSRDTQLSSFETRIFGDSIRGMKIRATHRPNAIRVYKVNSLQLPADKLMFQGIDEEGRQVVCSVADYFSEKYGPLKYPKLPCLHVGPPTRNIFLPMEHCLIDSPQKYNKKMTEKQTSAIIKAAAVDATQREDRIKQLAAQASFGTDPFLKEFGVAVSSQMIETSARVIQPPPIMFGGNNRSINPVVFPKDGSWSMDHQTLYMPATCRSYSMIALVDPRDQTSLQTFCQSLTMKATAMGMNFPRWPDLVKYGRSKEDVCTLFTEIADEYRVTNTVCDCIIVVLQSKNSDIYMTVKEQSDIVHGIMSQCVLMKNVSRPTPATCANIILKLNMKMGGINSRIVADQITNKYLVDQPTMVVGIDVTHPTQAEMRMNMPSVAAIVANVDLLPQSYGANVKVQKKCRESVVYLLDAIRERIITFYRHTKQKPARIIVYRDGVSEGQFSEVLREEIQSIRTACLAIAEDFRPPITYIVVQKRHHARIFCKFPNDMVGKAKNVPPGTTVDTGIVSPEGFDFYLCSHYGVQGTSRPARYHVLLDECKFTADEIQNITYGMCHTYGRCTRSVSIPTPVYYADLVATRARCHIKRKLGLADNNDCDTNSLSSSLASLLNVRTGSGKGKKSHAPSVDDESYSLPDAASDQILQDCVSVAADFKSRMYFI
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (G5E9A6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATVAANPAAAAAAVAAAAAVTEDREPQHEELPGLDSQWRQIENGESGRERPLRAGESWFLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIELPNIQKVEVYPVELLLVRHNDLGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAALETGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPARDYNNSYYGLMLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDGDEKEDDEEDKDDVPGPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQTVNSNGTSDRTTSPEEVHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKAPVRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSGAPASPACSSPPSSEFMDVN
Protein: DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1) (Q93VK1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- Nucleolar protein 56
- Ribosome biogenesis protein WDR12 homolog
- Protein ROOT INITIATION DEFECTIVE 3
- Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic
- DNA damage-binding protein 1a
- U3 small nucleolar ribonucleoprotein protein IMP3
- Protein SLOW WALKER 1
- Protein pleiotropic regulator PRL2
- F18K10.11 protein
- Protein DECREASED SIZE EXCLUSION LIMIT 1
Sequence:
MKIKTLSRSVDEYTRERSQDLQRVFHNFDPSLRPMEKAVEYQRALTAAKLEKIFARPFVGAMDGHRDGVSCMAKNPNYLKGIFSASMDGDIRLWDISSRRTVCQFPGHQGAVRGLTASTDGNVLVSCGTDCTVRLWNVPRPSLEDSSISSENFIEPSATYVWKNAFWAVDHQFEGDLFATAGAQLDIWNHNRSQPVQSFQWGTDSVISVRFNPGEPNLLATSASDRSITIYDLRLSSAARKIIMMTKTNSIAWNPMEPMNLTAANEDGSCYSFDGRKLDEAKCVHKDHVSAVMDIDFSPTGREFVTGSYDRSVRIFPYNGGHSREIYHTKRMQRVFCVKYSCDATYVISGSDDTNLRLWKAKASEQLGVILPREQKKHEYNEAVKNRYKHLSEVKRIVRHRHLPKPIYKAMGIIRTVNDSKRRKEARRKAHSAPGTVVTAPLRKRKIIKEVE
Protein: Evasin P1142 (A0A023FBW4)
Organism: Amblyomma cajennense (Cayenne tick) (Acarus cajennensis)
Function: Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL10 and CXCL11.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MTSHGAVKIAIFAVIALHSIFECLSKPQILQRTDHSTDSDWDPQMCPETCNPSKNISCSSECLCVTLGGGDETGTCFNMSGVDWLGHAQASDGHNDG
Protein: Probable prephenate dehydratase (PDT) (EC 4.2.1.51) (Phenylalanine-requiring protein 2) (P32452)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catayzes the decarboxylation/dehydration of prephenate to phenylpyruvate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Chorismate mutase
- Prephenate dehydrogenase [NADP
- Aromatic/aminoadipate aminotransferase 1
- Aromatic amino acid aminotransferase 2
- Histidinol-phosphate aminotransferase
- Chorismate synthase ARO2
- Pentafunctional AROM polypeptide
- Multifunctional tryptophan biosynthesis protein
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
Sequence:
MASKTLRVLFLGPKGTYSHQAALQQFQSTSDVEYLPAASIPQCFNQLENDTSIDYSVVPLENSTNGQVVFSYDLLRDRMIKKALSLPAPADTNRITPDIEVIAEQYVPITHCLISPIQLPNGIASLGNFEEVIIHSHPQVWGQVECYLRSMAEKFPQVTFIRLDCSSTSESVNQCIRSSTADCDNILHLAIASETAAQLHKAYIIEHSINDKLGNTTRFLVLKRRENAGDNEVEDTGLLRVNLLTFTTRQDDPGSLVDVLNILKIHSLNMCSINSRPFHLDEHDRNWRYLFFIEYYTEKNTPKNKEKFYEDISDKSKQWCLWGTFPRNERYYHK
Protein: Vacuolar amino acid transporter 4 (P50944)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:11274162}; Multi-pass membrane protein {ECO:0000269|PubMed:11274162}.
Interaction partners:
- Autophagy-related protein 22
- Vacuolar amino acid transporter 3
- Vacuolar amino acid transporter 6
- Vacuolar amino acid transporter 7
- Vacuolar basic amino acid transporter 2
Sequence:
MVTNNGDGEHLGIRRNGNLRHPSNNMKIPRRAQSTVLNSNPFYSRKYSMSTLTPRDICRSVDSRVFVDMSSPNFQTLEDPHRDEIINSVRLNYLNSSKRSSVSHGNEAIPRVNPTKNSSASTIAAANVDSDDDETNLSSAGGDITHDIYKLVKAEDPKRLRRPRSMENVTPKIEHHTKLSSASGLNVPGGFRREFIVNKKRQEHQLNDSASSDFTSHESDSINQSSPSSNQDIDKVPFLTRNFLEFLYVFGHFAGESFEDDFIPDSSNMMIRGEDERSALLSRPDHMKVLPSAKGTTSTKKVFLILLKSFIGTGVLFLPNAFHNGGLFFSVSMLAFFGIYSYWCYYILVQAKSSCGVSSFGDIGLKLYGPWMRIIILFSLVITQVGFSGAYMIFTAKNLQAFLDNVFHVGVLPLSYLMVFQTIIFIPLSFIRNISKLSLPSLLANFFIMAGLVIVIIFTAKRLFFDLMGTPAMGVVYGLNADRWTLFIGTAIFAFEGIGLIIPVQDSMRNPEKFPLVLALVILTATILFISIATLGYLAYGSNVQTVILLNLPQSNIFVNLIQLFYSIAIMLSTPLQLFPAIKIIENKFFPKFTKIYVKHDDLTTRVELRPNSGKLNWKIKWLKNFIRSIIVIIVVSIAYFGSDNLDKFVSVIGSLACIPLVYIYPSMLHLRGNSLPETKGEFWRFKPMLDTILIFFGIASMLYTSYQSIFGV
Protein: Conserved protein (O53874)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- DNA 3'-5' helicase XPB
- Pup deamidase/depupylase
- Molybdopterin synthase catalytic subunit 2
- Uncharacterized protein
- Probable molybdopterin biosynthesis Mog protein
- Pyruvate dehydrogenase E1 component
Sequence:
MTEHTPDIPLGSWLAALPDERLTQLLELRPDLAQPPPGSIAALAARAQARQSVKAATDELDFLRLAVFDALLVLQADTAPVPIVRLLAVIGDRAAQADVLGALADLKQRALAWGETAVRVATDAGTALPWHPGQVTLEGSSRSGDQLADLIAGLDPAQRDVLDKLLQGSPVGRTRDAAPGAPSDRPVPRLLAMGLLRRIDAETVILPRHVGQVLRGEQPGPMELTAPDPVVSTTTPDDADAAAAGAVIDLLREVDVLLENLGATPVAELRSGGLGVREFKRLAKATGIDEPRLGLILEIAAAAGLIASGMPDPEPPHSDGPFWAPTVAADRFATMSPAERWHLLASAWLDLPGRPALIGTRGPDAKPYGALSDSLFSTAAPLDRRLLLGMLAELPAGAGVDASRASATLIWRRPRWARRLQPAPIADLLTEGHALGLVGRGAISTPARALLDEALEPATAPAAAVGVMARALPKPIDHFLVQADLTVVVPGPLQRELADDLTTVATVESAGTAMVYRVSEQSIRHALDVGKSRDWLQEFFANRSKTPVPQGLTYLIDDVARRHGQLRIGMAASFVRCEDPTLLAQVVAAPEADGLALRALAPTVAVSPAPISEVLVTLRGAGFAPAAEDSTGAVVDVRTRGARVPTPQRRRPYRPPPRPNSEALKAVVAVLREVTAAPFANVRVDPAVTMSLLQRAAKDQATLVISYLDAAGVATQRVVAPITLRGGQLVAFDSSSGRLRDFAIHRITLVVSAHDR
Protein: Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) (Q8IZE3)
Organism: Homo sapiens (Human)
Function: May play a role in regulating cell adhesion/migration complexes in migrating cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12651155}. Golgi apparatus {ECO:0000269|PubMed:12651155}. Cell projection, lamellipodium {ECO:0000269|PubMed:12651155}. Note=Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.
Interaction partners:
- Ezrin
Sequence:
MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTTLPECHGHARDAFSFGTLVESLLTILNEQVSADVLSSFQQTLHSTLLNPIPKCRPALCTLLSHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKNTDLSLEDSPMCVVCSHHSQISPILENPFSSIFPKCFFSGSTPINSKKHIQRDYYNTLLQTGDPFSQPIKFPINGLSDVKNTSEDSENFPSSSKKSEEWPDWSEPEEPENQTVNIQIWPREPCDDVKSQCTTLDVEESSWDDCEPSSLDTKVNPGGGITATKPVTSGEQKPIPALLSLTEESMPWKSSLPQKISLVQRGDDADQIEPPKVSSQERPLKVPSELGLGEEFTIQVKKKPVKDPEMDWFADMIPEIKPSAAFLILPELRTEMVPKKDDVSPVMQFSSKFAAAEITEGEAEGWEEEGELNWEDNNW
Protein: Attacin-A (AttA) (GmAttA) (Q8WTD3)
Organism: Glossina morsitans morsitans (Savannah tsetse fly)
Function: Hemolymph antibacterial protein against Gram-negative bacteria.
Subcellular location: Secreted {ECO:0000269|PubMed:11592981, ECO:0000269|PubMed:11886771}.
Interaction partners:
Sequence:
MQSFKICFFISCLSVVLVKGQFGGTVSSNPNGGLDVNARLSKTIGDPNANVVGGVFAAGNTDGGPATRGAFLAANKDGHGLSLQHSKTDNFGSSLTSSAHAHLFNDKTHKLDANAFHSRTHLDNGFKFDRVGGGLRYDHVTGHGASLTASRIPQLDMNTLGLTGKANLWSSPNRATTLDLTGGVSKHFGGPFDGQTNKQIGLGLNSRF
Protein: Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) (Q6NRT0)
Organism: Xenopus laevis (African clawed frog)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MDPNNREKDDRPRPAKALPVRTGHSSRPSSSTTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGNTAEGLPQVFYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHIIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPVEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRTLFSELFERKGYTFDCVYDWVGRPIPTPGGSVHVDSGTSAITRESHAHRERPSQTQPLRNQTGVPDRRGAWDLQVGRQAHPAYLVPHLASDRHGGSVQVMSSTNGQLNADDQTGGHSNAPITAQAEVEVVEEAKCCCFFKRKRKNHSQRHHK
Protein: Antitoxin EndoAI (Antitoxin MazE-bs) (MazE-bs) (EndoA inhibitor) (P96621)
Organism: Bacillus subtilis (strain 168)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that directly inhibits activity of EndoA in vitro. Upon expression in E.coli counteracts inhibitory effect of endoribonuclease EndoA. The EndoA-EndoAI complex does not seem to bind its own promoter.
Interaction partners:
- Endoribonuclease EndoA
- Stage V sporulation protein T
- Stage II sporulation protein SA
- Protein CcdB
- RNA-binding protein Hfq
Sequence:
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG
Protein: Cellular tumor antigen p53 (C9D7D0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU003304}. Nucleus {ECO:0000256|RuleBase:RU003304}.
Interaction partners:
Sequence:
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANRSGKSENP
Protein: Colicin-E9 immunity protein (ImmE9) (Microcin-E9 immunity protein) (P13479)
Organism: Escherichia coli
Function: This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.
Interaction partners:
Sequence:
MELKHSISDYTEAEFLQLVTTICNADTSSEEELVKLVTHFEEMTEHPSGSDLIYYPKEGDDDSPSGIVNTVKQWRAANGKSGFKQG
Protein: Regulator of G protein-signaling 3a (Zgc:100933) (Q6DC84)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Si:ch211-154e10.1.
- Zinc finger protein 710
- PHD finger protein 20, b
Sequence:
MKNRLAFLRRRNESPGSTPASKLDKTMKSVKPTPEEAMKWGESLDKLLVHKYGLAAFRAFLRTEFSEENLDFWLACEDYKKIKSQSKMTSKAKKIFAEFIAIQSCKEVNLDSYTREHTKENLQNINRSCFELAQRRIYGLMEKDSYPRFLRSELYMDLVNQKKPSTTSTSSSS
Protein: RNaseL inhibitor-like protein (Q8T8P2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Eukaryotic peptide chain release factor subunit 1
- Small ribosomal subunit protein eS30
- Eukaryotic translation initiation factor 3 subunit J
- Eukaryotic translation initiation factor 3 subunit C
- Protein pelota homolog
- Eukaryotic translation initiation factor 3 subunit B
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS3
- Eukaryotic translation initiation factor 1
Sequence:
MADDAIRIAIVNADRCKPKKCSQECKKYCPVVKMGKLCIEVKPTSKMSYISEELCNGCGICVKKCPFEAIQIINLPKNLTKETTHRYGPNSFKLHRLPTPRPGQVLGLVGTNGIGKSTALKVLAGKLKPNLGLYDNPPTWDEIISFFRGNELQSYFTRILGEDLKALIKPQYVDNLSKAVTGVVSSILDAKSEKDNKQEMIDCLDLKEALHKTVPVLSGGELQRFAIAVVAIQKADVYMFDEPSSYLDVKQRLKAAQVIRGLIQSQNYIIVVEHDLSVLDYLSDFICCLYGAPGAYGVVTLPFSVREGINIFLSGYIHTENMRFRKDALTFKFSETAENEEEIKKHCNYKYPNMTKTMGTFKLEIKAGQFTDSEIIVMLGQNGTGKTTFIRMLAGHMPSDTDAQVPELNVSYKPQKIDPKFPGSVRELINKRICNTFLHPQFQSDVVKPLNIENIIDNQVLNLSGGELQRVAIVLCLGQPADIYLIDEPSAYLDSEQRIIVSKVIKRFILHAGKSGFIVEHDFIMATYLADRVIVYDGIPGVSCVANTPQSLLTGMNSFLKSLEITFRRDPSNFRPRINKLNSIKDNEQKAAGNYFFLDNVDE
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI) (P79331)
Organism: Bos taurus (Bovine)
Function: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Collagen alpha-2
- Collagen alpha-1
- Collagen type III alpha 1 chain
- Collagen type V alpha 1 chain
- Fibrillin-1
- Collagen type V alpha 2 chain.
- Tenascin XB
- Beta-1,3-glucosyltransferase
Sequence:
MDPPAGAAGRLLCPALLLLLLLPLPADARLAAAAADPPGGPQGHGAERILAVPVRTDAQGRLVSHVVSAATAPAGVRTRRAAPAQIPGLSGGSEEDPGGRLFYNVTVFGRDLHLRLRPNARLVAPGATVEWQGESGATRVEPLLGTCLYVGDVAGLAESSSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAKEAEQGRVHVVYHRPTTSRPPPLGGPQALDTGISADSLDSLSRALGVLEERVNSSRRRMRRHAADDDYNIEVLLGVDDSVVQFHGTEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTDHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLRDDPFTHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGNWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCNSQDCPDALADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESKETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFSRSPKKLGYIKMFEIPAGARHLLIQEADTTSHHLAVKNLETGKFILNEENDVDPNSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPEGDARISLTYKYMIHEDSLNVDDNNVLEDDSVGYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCDSVSKPKAIRRTCNPQECSQPVWVTGEWEPCSRSCGRTGMQVRSVRCVQPLHNNTTRSVHTKHCNDARPEGRRACNRELCPGRWRAGSWSQCSVTCGNGTQERPVLCRTADDSFGVCREERPETARICRLGPCPRNTSDPSKKSYVVQWLSRPDPNSPVQETSSKGRCQGDKSVFCRMEVLSRYCSIPGYNKLCCKSCNPHDNLTDVDDRAEPPSGKHNDIEELMPTLSVPTLVMEVQPPPGIPLEVPLNTSSTNATEDHPETNAVDVPYKIPGLEDEVQPPNLIPRRPSPYEKTRNQRIQELIDEMRKKEMLGKF
Protein: Calmodulin, putative (Q383V0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MADLLTVEQITELKEAFAVFDTDCDGNITVDDLSNVFAAIGQKVSREKLQMMMNEADLDSNGVIDFPEFLTLVATKLNDPEEKELKLRRAFELYDLGNTGFITTTDLRIVMERLGCYLTPEKAFEMINEADLDGDGRLSYEEFRRVMVEDSGSIPKKEAFSTD