wanglab/gogpt-training-data huggingface dataset:
Protein: Rhodanese-like/PpiC domain-containing protein 12, chloroplastic (Sulfurtransferase 12) (AtStr12) (Q93WI0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Rhodanese-like domain-containing protein 11, chloroplastic
- Peptidyl-prolyl cis-trans isomerase
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 2
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial
- Molybdopterin synthase catalytic subunit
- Peptidyl-prolyl cis-trans isomerase Pin1
- Autophagy-related protein 3
- At5g58750
- Probable purine permease 5
- Probable NEDD8-conjugating enzyme Ubc12-like
Sequence:
MFRVTGTLSAASSPAVAAASFSAALRLSITPTLAIASPPHLRWFSKFSRQFLGGRISSLRPRIPSPCPIRLSGFPALKMRASFSSGSSGSSASREILVQHLLVKNNDVELFAELQKKFLDGEEMSDLAAEYSICPSKKDGGILGWVKLGQMVPEFEEAAFKAELNQVVRCRTQFGLHLLQVLSEREPVKDIQVEELHSKMQDPVFMDEAQLIDVREPNEIEIASLPGFKVFPLRQFGTWAPDITSKLNPEKDTFVLCKVGGRSMQVANWLQSQGFKSVYNITGGIQAYSLKVDPSIPTY
Protein: Epididymis secretory sperm binding protein (A0A384MDT9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSGSLGRAAAALLRWGRGAGGGGLWGPGVRAAGSGAGGGGSAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIHSALLDEKKDQDSK
Protein: Protein 4.1 (Band 4.1) (Erythrocyte membrane protein band 4.1) (D3ZKF7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cell cortex {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTTEKSLAAEAENSQHQKEEGEGATNSGQQESQLEEASQAAAAEGSNQGEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLLSSFLKRPKSQVSEEEGREVESEREKGEGEQKETELGTSLDEDVILKAPIAAPEPELKTDPSLDLHSLSSIETQPAQEEHREDPDSETKEGEGIEECSGTEVKEDPESRAEREPETSQKPIRRHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAVWDSTTSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTVQSELGDYDPELHGVDYVSDFKLAPNQTRELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTLPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAAESTDRSPRPTSAPAIAQSQVMEGPGAPAKKAPKEAVKVEEKRGEEPAEPEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQVPTGDGPPLVKTQTVTISDTANAVKSEIPTKDVPIVHTETKTITYEAAQTEDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEISEE
Protein: DNA repair and recombination protein RAD54-like (Protein okra) (G5EEN6)
Organism: Caenorhabditis elegans
Interaction partners:
- DNA repair protein RAD51 homolog
- Crossover junction endonuclease MUS81
- Meiotic recombination protein spo-11
- DNA topoisomerase 3
- Exonuclease 1
- RAD51-like protein 1
- DNA replication ATP-dependent helicase/nuclease DNA2
- RecQ-like DNA helicase blm-1
- DNA repair and recombination protein RAD54-like
- DNA ligase IV
Sequence:
MPKKTFENLEDSHGKDVNIPVELPKRKREVTPENLPSTSSTAPTQKRKSLGYSGRTEEPKNIHKTFISPFSTSVSPSKQGLRRRKKALPAIEPPVSVEEASPLRFVNIDVFSRRMASESSDHDAMIAKLLSRKFSIPMEGYMLSGRSLGLGGNRRKCALFDPYHEGALILYAPEHLSEHAQLKEDKDRKVHVVADPVVGKILRPHQRDGVKFMWDCVTGINIPEFHGCIMADEMGLGKTLQCISLLWTLLRQSPDACPTVSKSIIVCPSSLVKNWDKEIKKWLGTRLNAMPVDSGKREQIIACLNSFMADSKMRCAIPVLIISYETFRLYANILHSGDVGIVICDEGHRLKNSENLTYQALSGLKCARRVLISGTPIQNDLLEYFSLVNFVNPGLLGTASEFRKKFENAILKGRDADASSEDQKKGEEKTKEMISLVEKCIIRRTSALLTKYLPVKYEHIICCKNSTLQETLYNKLIECEKQNRIVEKDKGATASALSFITHLKKLCNHPYLVYDEFQKPDNRFRNKCLSIFPESFNPKSFDPSFSGKMKVLDYILAVTRKTTDDKFVLVSNYTQTIDQFMELCKLRGYDFVRLDGSMSIKQRSKIVDTFNDPASTIFCFLLSSKAGGCGLNLIGANRLVMFDPDWNPANDDQAMARVWRDGQKKMCFIYRLLATGSIEEKMFQRQTHKKALSSCVVDAGEDVARHFSSEQLRELFKLESTVASDTHEKLKCKRCIQGVESVDPPTNADCASDLSNWFHSQKSARKVADNVLRAVFECGSISFVFHQKSHNVEVKKVQEKVEEVDEDYVPSEAEENDD
Protein: DNA repair protein RAD51 homolog (Q59UY8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364139}.
Interaction partners:
- DNA repair and recombination protein RAD52
- DNA-dependent ATPase
- DNA 3'-5' helicase
- Rad2 family nuclease
- Replication protein A subunit
- Recombinase
- DNA-dependent ATPase
- DNA repair and recombination protein RAD52
- DNA 3'-5' helicase
- DNA repair and recombination protein RDH54
Sequence:
MTQTEIEQVDLHEEGSHPQNINADAEVEAEEDEDVLNGPLLIEQLEGNGINASDIKKLKAEGFHTIESIAYTPKRHLMTVKGISENKAEKISAEAAKLVPLGFTTASEFHSRRSELICLTTGSKQLDTLLGGGVETGSITEVFGEFRTGKSQLCHTLAVTCQLPIDMGGGEGKCLYIDTEGTFRPNRLVSIAQRYGLNPNDCLDNVAYARAYNAEHQLNLLNIAAEMMAESRFSLLIVDSIMSLYRTDYAGRGELSARQTHVAKFMRTLQRLADEFGIAVVITNQVVAQVDGMSGMFNPDPKKPIGGNIIAHSSTTRLSFKKGRGETRICKIYDSPCLPESECIFAIYEDGIGDPKVEDNE
Protein: Bcl-2-binding component 3 (p53 up-regulated modulator of apoptosis) (Q80ZG6)
Organism: Rattus norvegicus (Rat)
Function: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis. Regulates ER stress-induced neuronal apoptosis.
Subcellular location: Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. {ECO:0000250}.
Interaction partners:
Sequence:
MARARQEGSSPEPVEGLARDSPRPFPLGRLMPSAVSCGLCEPGLPAAPAAPALLPAAYLCAPTAPPAVTAALGGPRWPGGHRSRPRGPRPDGPQPSLSPAQQHLESPVPSAPEALAGGPTQAAPGVRVEEEEWAREIGAQLRRMADDLNAQYERRRQEEQHRHRPSPWRVMYNLFMGLLPLPRDPGAPEMEPN
Protein: Exocyst complex component sec6 (O74846)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cell tip {ECO:0000269|PubMed:11854409}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Exocyst complex component exo70
- Exocyst complex component exo84
- Exocyst complex component sec15
- Exocyst complex component sec10
- Exocyst complex component sec8
- Exocyst complex component sec5
- Uncharacterized protein C17G8.12
- Protein transport protein sec9
- Protein transport protein sec1
- F-box protein pof6
Sequence:
MTAAASDDAVYNKVADILRQCEDFHRLSTHIERFEREQASLNMHVKTELEKHVEAVELGKLALHDAQTKRVKLLQELHNMLTLCESAREMVDEFPLISRMSRIYKNCYATKQMISQLNNLVKETDVIEDMLREDLELDSDMPNLLRAHYKLSKLREFREEALYQASLEGQSDLPITLENSFSNLNTLSDNFDRLVLNFCRNIFQLVKSGHIKTIVQIFKIVEAEESSDEVLKSIRDAKSSLPDSQDGPFLSLQGMTRQLRNFRLRVLEEFQGAAAENFQRAWVSYLEDGSGELNLDFIFEDLKVAFYVLPDLTPPSYNIAKTFASIYQECLVGLVTKAVSLDTPAAVYLYLINFHREYRKFFEENAPFSVDEVEPGLEDGKDGILVREYTRLFTQKIREWSDKLFQSSVDTFMKRESEPELDSDGNYGLQGTIIFFQMITQQINIISHTNNSDVVGIVLSSIMYIMQSMQDQWKSVMRSELSQQLSGNPESVPPGLMEYLLAVANDNLKCAGFMDNTLLNTFELITSEREEDLREAFGKTVDGYILISDIGVSQIVAIISNDVKPALTSLFQPNWYQSSNMKLIVDTFRDYIVDCIEHMVPGLFDVFLLEASNALTISYLRSIFNKNACFDGDNAIQQIRSDIALAIRVFGEYMAAEHLRSTFEPIEKLLLGMLDADVETVSEYFHLLKEAYWDAPLSLVEAVLQNRTDLEKSIIKKMIDIVRHENDSLQIDTSQQPTVFSQVTSLSGSSIL
Protein: Rac GTPase activating protein 1 (F8VRD2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDTMMLNVRNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHELGKYKDLLMKAETERSALDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEEQKSALAFLNRGQPSSSNAGNKRLSTIDESGSILSDISFDKTDESLDWDSSLVKTFKLKKREKRRSTSRQFVDGPPGPVKKTRSIGSAVDQGNESIVAKTTVTVPNDGGPIEAVSTIETVPYWTRSRRKTGTLQPWNSDSTLNSRQLEPRTETDSVGTPQSNGGMRLHDFVSKT
Protein: Stabilizer of axonemal microtubules 2 (Q658L1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGAKSMRSWCLCQICSCGSDYCPYEIVKQPRHVPEEYKPKQGKIDLGTTYKRDLNSYKVQPVAIVRPLERQVKKGKLDTVPTYKDDYRAWDLHKSELYKPEQTYHPPTVKFGNSTTFQDDFVPQEIKPRQSFKPSSVVKRSTAPFNGITSHRLDYIPHQLELKFERPKEVYKPTDQRFEDLTTHRCDFQGLIGETAKLCRPVHTRVTQNALFEGSTEFRESFQPWEIPPPEVKKVPEYVPPTGSMLLNSTSHLDYVPYQANHVVPIRPVSQKRSNNFPFQGKSIMKEDFPAWESCRQGLIKKQQQIPNPSGKFDGLSTFRSHYVPHELIPTESCKPLNIAFKSSVPFDDVTMYSVEYTPKRQEICPASYPSPPGYIFDNTNSQGHKFFRKIIPAVKAF
Protein: Uncharacterized protein Rv2305 (P9WLD1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv2307c
- Uncharacterized protein Rv2304c
- Uncharacterized protein Rv2082
- Polyketide synthase Pks13
- Phenyloxazoline synthase MbtB
- TVP38/TMEM64 family membrane protein
- PE-PGRS family protein PE_PGRS43
- Isoniazid-induced protein IniB
- TVP38/TMEM64 family membrane protein
- PE-PGRS family protein PE_PGRS42
Sequence:
MTQTLRLTALDEMFITDDIDIVPSVQIEARVSGRFDLDRLAAALRAAVAKHALARARLGRASLTARTLYWEVPDRADHLAVEITDEPVGEVRSRFYARAPELHRSPVFAVAVVRETVGDRLLLNFHHAAFDGMGGLRLLLSLARAYAGEPDEVGGPPIEEARNLKGVAGSRDLFDVLIRARGLAKPAIDRKRTTRVAPDGGSPDGPRFVFAPLTIESDEMATAVARRPEGATVNDLAMAALALTILQWNRTHDVPAADSVSVNMPVNFRPTAWSTEVISNFASYLAIVLRVDEVTDLEKATAIVAGITGPLKQSGAAGWVVDLLEGGKVLPAMLKRQLQLLLPLVEDRFVESVCLSNLGRVDVPAFGGEAGDTTEVWFSPTAAMSVMPIGVGLVGFGGTLRAMFRGDGRTIGGEALGRFAALYRDTLLT
Protein: Nuclear import protein mog1 (O75002)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the Ran-GTPase system for nuclear protein import and poly(A)+ mRNA export. Required for mitosis-to-interphase transition.
Subcellular location: Nucleus {ECO:0000269|PubMed:11290708}.
Interaction partners:
- GTP-binding nuclear protein spi1
- Nuclear transport factor 2
- SAC3 family protein 2
- Uncharacterized RNA-binding protein C106.12c
- SAC3 family protein 1
- Ran-specific GTPase-activating protein 1
- Poly
- Uncharacterized protein P25A2.03
Sequence:
MVQLFGGALCADFPPKFLDASVLRQIPDNQEVFLQDSKENLTVIIELLEKIEKPFDGSVAAYHFNSIAFDNDASQRVIWRDKSLGEDDFEGMRSEKASGSSVQGCQRVLEKGKRNPESATNVAIFVNVITLIDFQTDIVISVNAPLPNTSSVPSSVENIPPSDQSIVRAALETIQRVTRSLVLVDKTVFA
Protein: Fibroblast growth factor 8 (FGF-8) (Androgen-induced growth factor) (AIGF) (Heparin-binding growth factor 8) (HBGF-8) (P55075)
Organism: Homo sapiens (Human)
Function: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells.
Subcellular location: Secreted.
Interaction partners:
- Fibroblast growth factor receptor 3
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Klotho
- Pro-epidermal growth factor
- Sonic hedgehog protein
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Decorin
- Fibroblast growth factor 23
Sequence:
MGSPRSALSCLLLHLLVLCLQAQEGPGRGPALGRELASLFRAGREPQGVSQQHVREQSLVTDQLSRRLIRTYQLYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSRVRVRGAETGLYICMNKKGKLIAKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFTRKGRPRKGSKTRQHQREVHFMKRLPRGHHTTEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR
Protein: Autophagy-related protein 101 (Q9D8Z6)
Organism: Mus musculus (Mouse)
Function: Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BSB4}. Preautophagosomal structure {ECO:0000250|UniProtKB:Q9BSB4}. Note=Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000250|UniProtKB:Q9BSB4}.
Interaction partners:
- Serine/threonine-protein kinase ULK2
- RB1-inducible coiled-coil protein 1
- Serine/threonine-protein kinase ULK1
- Autophagy-related protein 13
- Serine/threonine-protein kinase mTOR
- Beclin 1-associated autophagy-related key regulator
- Regulatory-associated protein of mTOR
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Phosphoinositide 3-kinase regulatory subunit 4
- Guanine nucleotide exchange factor C9orf72 homolog
Sequence:
MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGIQDVDCDFIDFTYVRVSSEELDRALRKVVGEFKDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMSRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITEALGTSVTTTMRRLIKDTLAL
Protein: Galectin (Q8I4A5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MPSVWHCAKYINIPYRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDSPDFSGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEERAKNPIKKGDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQWGGKYYPVPYESGIAADGLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEKANGFMCAKPTPGVGSFV
Protein: Glucokinase regulatory protein (GKRP) (Glucokinase regulator) (Q91X44)
Organism: Mus musculus (Mouse)
Function: Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q14397}. Nucleus {ECO:0000269|PubMed:10713097}. Mitochondrion {ECO:0000250|UniProtKB:Q07071}. Note=Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000250|UniProtKB:Q14397}.
Interaction partners:
- Hexokinase-4
- Hexokinase-1
- Hexokinase-3
- Hexokinase HKDC1
- Hexokinase-2
- Pro-glucagon
Sequence:
MPSTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVQLLGQCDAEIFQEEGQIMPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASRERTEDSALHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFERAHQVTYSQSSKIATLTKQVGISLEKKGHVHLVGWQTLGIIAIMDGVECIHTFGADFRDIRGFLIGDHNDMFNQKDELSNQGPQFTFSQDDFLTSVLPSLTEIDTVVFIFTLDDNLAEVQALAERVREKSWNIQALVHSTVGQSLPAPLKKLFPSLISITWPLLFFDYEGSYVQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRIANSKLFWRALAMLQRFSGQSKARCIESLLQVIHFPQPLSNDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSITEAKERLAAASSVCEVVRSALSGPGQKRSIQAFGDPVVP
Protein: 110 kDa U5 small nuclear ribonucleoprotein component CLO (Protein CLOTHO) (Protein GAMETOPHYTE FACTOR 1) (Protein MATERNAL EFFECT EMBRYO ARREST 5) (Protein VAJRA-1) (SNU114 homolog) (Q9LNC5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Splicing factor involved in pre-mRNA splicing and component of the spliceosome. Essential for reproduction. In female gametophyte, is necessary for the egg cell and central cell fate determination and hence reproductive success. Involved in a mechanism that prevents accessory cells from adopting gametic cell fate. Is necessary to restrict LIS expression to interfere with egg-cell specification. Probable component of U5 small nuclear ribonucleoprotein (snRNP) that is required for pre-mRNA splicing. Plays an essential role in female gametogenesis and embryo development. Required for the control of polarized cell growth and cell proliferation during floral organ morphogenesis.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:18702672, ECO:0000269|PubMed:19168457}. Note=Colocalizes with CLO (PubMed:18702672). Colocalizes with SC35 (PubMed:19168457). {ECO:0000269|PubMed:18702672, ECO:0000269|PubMed:19168457}.
Interaction partners:
- Protein STABILIZED1
- Pre-mRNA-processing-splicing factor 8A
- Pre-mRNA-processing-splicing factor 8B
- DExH-box ATP-dependent RNA helicase DExH12
- Small nuclear ribonucleoprotein Sm D2
- Splicing factor SF3a60 homolog
- Small nuclear ribonucleoprotein E
- Thioredoxin-like protein YLS8
- Small nuclear ribonucleoprotein E
- Tetratricopeptide repeat
Sequence:
MESSLYDEFGNYVGPEIESDRDSDDEVEDEDLQDKHLEENGSDGEQGPGGSNGWITTINDVEMENQIVLPEDKKYYPTAEEVYGEDVETLVMDEDEQPLEQPIIKPVRDIRFEVGVKDQATYVSTQFLIGLMSNPALVRNVALVGHLQHGKTVFMDMLVEQTHHMSTFNAKNEKHMKYTDTRVDEQERNISIKAVPMSLVLEDSRSKSYLCNIMDTPGHVNFSDEMTASLRLADGAVLIVDAAEGVMVNTERAIRHAIQDHLPIVVVINKVDRLITELKLPPRDAYYKLRHTIEVINNHISAASTTAGDLPLIDPAAGNVCFASGTAGWSFTLQSFAKMYAKLHGVAMDVDKFASRLWGDVYYHSDTRVFKRSPPVGGGERAFVQFILEPLYKIYSQVIGEHKKSVETTLAELGVTLSNSAYKLNVRPLLRLACSSVFGSASGFTDMLVKHIPSPREAAARKVDHSYTGTKDSPIYESMVECDPSGPLMVNVTKLYPKSDTSVFDVFGRVYSGRLQTGQSVRVLGEGYSPEDEEDMTIKEVTKLWIYQARYRIPVSSAPPGSWVLIEGVDASIMKTATLCNASYDEDVYIFRALQFNTLPVVKTATEPLNPSELPKMVEGLRKISKSYPLAITKVEESGEHTILGTGELYLDSIMKDLRELYSEVEVKVADPVVSFCETVVESSSMKCFAETPNKKNKITMIAEPLDRGLAEDIENGVVSIDWNRKQLGDFFRTKYDWDLLAARSIWAFGPDKQGPNILLDDTLPTEVDRNLMMAVKDSIVQGFQWGAREGPLCDEPIRNVKFKIVDARIAPEPLHRGSGQMIPTARRVAYSAFLMATPRLMEPVYYVEIQTPIDCVTAIYTVLSRRRGHVTSDVPQPGTPAYIVKAFLPVIESFGFETDLRYHTQGQAFCLSVFDHWAIVPGDPLDKAIQLRPLEPAPIQHLAREFMVKTRRRKGMSEDVSGNKFFDEAMMVELAQQTGDLHLQMI
Protein: Probable LRR receptor-like serine/threonine-protein kinase At2g02780 (EC 2.7.11.1) (C0LGJ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Probable LRR receptor-like serine/threonine-protein kinase At1g53430
Sequence:
MQISLQIHLSSFTFLLLIFLLPVLSESQVASSESQTLLEIQKQLQYPQVLQSWTDTTNFCHIRPSPSLRIICLHGHVTELTVTGNRTSKLSGSFHKLFTLLTQLSSLKTLSLTSLGISGSLSPKIITKLSPSLESLNLSSNFISGKIPEEIVSLKNLKSLVLRDNMFWGFVSDDLRGLSNLQELDLGGNKLGPEVPSLPSKLTTVSLKNNSFRSKIPEQIKKLNNLQSLDLSSNEFTGSIPEFLFSIPSLQILSLDQNLLSGSLPNSSCTSSKIITLDVSHNLLTGKLPSCYSSKSFSNQTVLFSFNCLSLIGTPNAKYQRPLSFCQNQASKAIAVEPIPKAKDKDSARIKLGLVILIIIGVIILAAILVLLVLIALKRRRSRSEDDPFEVNNSNNERHASDKVSVCSTTTASSKSLPDSRRVPQTMRSAVIGLPPYRVFSLEELEEATNDFDAASLFCEQLYRGCLREGIPVTVRVIKLKQKSLPQSLAQQMEVLSKLRHMHLVSVLGHSIASNQDHNQHAGHTIFIVQEYISSGSLRDFLTNCRKKEVLKWPQRMAIAIGVARGIQFLHMGVAPGIFGNNLKIENIMLDETLTVKISGYTIPLPSKVGEERPQAKKPRSNEDREKEDVYQFGVILLQIITGKVVAAGSSEMGSLKLQLENGLRDEPSVLSSLADPSVKGSYAYESLRTTVEFAINCLCEDQSKRPSIEDVVWNLQYTIQVQQGWRPSSGNHESSMKAIYE
Protein: Uncharacterized protein (Q38BT9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRILVCWAVGVKKGRMMAPPLIFCLYVLSEIIDRFLFFIPDCSSFVWHIFFRFKYFGRTLIDGTICYWWSSKVAVVMDAADATGGGSVKPLAELIQLIRVRGGVTKECARPRRTNDHSNDLCAVPFSLPVWKRARGHSPPRAALPVKESVSRRPELSTTVRRRRRRMEGCHAVTTRNVSTCSADFQIMEKLSVGAYHLTYVHVDLYHHGLKRLMDDAVLRTNPKKIVGRKCCYLKPGTDLVVTGCVIEFTKNDLSVQVAPDKGIDVDVEWVKLEDVYVPENIDKVRVRVSDEVRSGLQKVKEAPKEMRRRFASQ
Protein: Serine/threonine-protein kinase orb6 (EC 2.7.11.1) (O13310)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Interacts with pak1/shk1 and coordinates cell morphogenesis with the cell cycle. It is essential for maintenance of cell polarity and is involved in mitotic control.
Interaction partners:
- Maintenance of ploidy protein mob2
- Cell polarity protein mor2
- Mo25-like protein
- Leucine-rich repeat-containing protein sog2
- Maintenance of ploidy protein mob1
- Cell division control protein 42 homolog
- Protein sts5
- Protein arginine N-methyltransferase skb1
- cAMP-dependent protein kinase regulatory subunit
- Rho guanine nucleotide exchange factor gef1
Sequence:
MDKNDYLHFERNPSLFPKSTLDKVQKTKKYIEHYYKVAVDHAVERNQRRINLEQRLATERGSEERKNRQLRASGEKESQFLRFRRTRLSLEDFSTIKVIGKGAFGEVRLVQKLDTGKIYAMKSLLKTEMFKRDQLAHVKAERDLLVESDSPWVVSLYYAFQDSLYLYLIMEFLPGGDLMTMLINYDTFSEDVTRFYMAECVLAIADVHRMGYIHRDIKPDNILIDRDGHIKLSDFGLSTGFYKQDQSASYMKPRTGNTVKRGQMVDAIWLTMSSKDKMATWKKNRRVMAYSTVGTPDYIAPEIFLQQGYGQDCDWWSLGAIMFECLIGWPPFCSENSHETYRKIINWRETLTFPNDIHLSIEARDLMDRLMTDSEHRLGRGGAIEIMQHPFFTGIDWDHIRETAAPFIPNLKSITDTHYFPVDELEQVPEQPVTQQPASVDPQTLEQTNLAFLGYTYKKFNYLTMKGAL
Protein: CX domain-containing protein (Q9U2Y6)
Organism: Caenorhabditis elegans
Interaction partners:
- SPE-12
- Spermatocyte protein spe-8
- Spermiogenesis protein SPE-29
- Spermatocyte protein spe-27
- Uncharacterized protein
- Domain of unknown function DX domain-containing protein
- Serine/threonine-protein kinase spe-6
- TRP homologous cation channel protein
- Trypsin-like protease try-5
- Transporter
Sequence:
MQIFFLFFKFLKTMAENGEMKYLECYTTKEVIYDKFPKFTLEGEHTTIATYNITHESKTGPPACVMFFGTNGTHSATWQGHVSSFALPLECHINSKSYTHCFKSPNPFVFLELPNGWACCCSGHNCNWHNPSFFQFFERFILDNSELFNRLKAVCKYSFCIVFCVFITILWTIVEVLLTNLCEKRRKTCEESEFEMRNKIPSSLQLQPTQSSLKSRSGKNLSEMSLHPGSTLKVEKTQEDDVTEPKRSELEVASTQRSRINKDDDFVPIPEKPEWQTTKNGRLRRTSMNYEESTYSVLQE
Protein: Toxin GhoT (P64646)
Organism: Escherichia coli (strain K12)
Function: Toxic component of a type V toxin-antitoxin (TA) system. Causes membrane damage when induced by MqsR, slowing cell growth and increasing the formation of dormant persister cells; involved with GhoS, its antitoxin, in reducing cell growth during antibacterial stress. Overexpression causes cell lysis, forming ghost cells; both effects are neutralized by expression of GhoS. Overexpression in the presence of ampicillin increases persister cell formation (persister cells exhibit antibiotic tolerance without genetic change). Overexpression causes about 90-fold reduction in cellular ATP levels and dissipates the membrane potential.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:24373067}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes to the cell pole. {ECO:0000269|PubMed:24373067}.
Interaction partners:
- Endoribonuclease antitoxin GhoS
- mRNA interferase toxin MqsR
- Small toxic protein TisB
- Cytoskeleton bundling-enhancing antitoxin CbeA
- Antitoxin MqsA
- Cytoskeleton-binding toxin CbtA
- Endodeoxyribonuclease toxin RalR
- Toxic protein HokB
- Endoribonuclease toxin MazF
- mRNA interferase toxin RelE
Sequence:
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
Protein: Olfactory receptor 51E2 (HPRAJ) (Olfactory receptor OR11-16) (Prostate-specific G-protein coupled receptor) (Q9H255)
Organism: Homo sapiens (Human)
Function: Olfactory receptor. Activated by the odorant, beta-ionone, a synthetic terpenoid. The activity of this receptor is probably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1. Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis. Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells. Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure. May also be activated by steroid hormones and regulate cell proliferation. Activated by L-lactate in glomus cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:23401498, ECO:0000269|PubMed:27226631, ECO:0000269|PubMed:29249973}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:27226631}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Alpha-methylacyl-CoA racemase
- Guanine nucleotide-binding protein G
- Adenylate cyclase type 3
- Guanine nucleotide-binding protein G
Sequence:
MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK
Protein: Feruloyl-CoA synthase (EC 6.2.1.34) (Feruloyl coenzyme A synthetase) (Feruloyl-CoA synthetase) (S5M744)
Organism: Streptomyces sp
Function: Catalyzes the formation of (E)-feruloyl-CoA, AMP and diphosphate from (E)-ferulate, CoA and ATP. Active also with caffeate and 4-coumarate. Less active with trans-cinnamic acid. Not active with 3-methoxycinnamic acid or 4-methoxycinnamic acid. Involved in the degradation pathway of lignin-derived aromatic compounds of plant cell walls. Catalyzes the first enzymatic step in the conversion of ferulic acid into high value compound vanillin.
Interaction partners:
Sequence:
MRNQGLGSWPVRRARMSPHATAVRHGGTALTYAELSRRVARLANGLRAAGVRPGDRVAYLGPNHPAYLETLFACGQAGAVFVPLNFRLGVPELDHALADSGASVLIHTPEHAETVAALAAGRLLRVPAGELDAADDEPPDLPVGLDDVCLLMYTSGSTGRPKGAMLTHGNLTWNCVNVLVETDLASDERALVAAPLFHAAALGMVCLPTLLKGGTVILHSAFDPGAVLSAVEQERVTLVFGVPTMYQAIAAHPRWRSADLSSLRTLLCGGAPVPADLASRYLDRGLAFVQGYGMTEAAPGVLVLDRAHVAEKIGSAGVPSFFTDVRLAGPSGEPVPPGEKGEIVVSGPNVMKGYWGRPEATAEVLRDGWFHSGDVATVDGDGYFHVVDRLKDMIISGGENIYPAEVENELYGYPGVEACAVIGVPDPRWGEVGKAVVVPADGSRIDGDELLAWLRTRLAGYKVPKSVEFTDRLPTTGSGKILKGEVRRRFG