wanglab/gogpt-training-data huggingface dataset:
Protein: Neuronal acetylcholine receptor subunit alpha-5 (P20420)
Organism: Rattus norvegicus (Rat)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Synaptic cell membrane {ECO:0000250|UniProtKB:P32297}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P32297}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neuronal acetylcholine receptor subunit alpha-4
- Neuronal acetylcholine receptor subunit beta-4
- Neuronal acetylcholine receptor subunit alpha-3
- Acetylcholine receptor subunit alpha
- Neuronal acetylcholine receptor subunit beta-2
- Neuronal acetylcholine receptor subunit alpha-9
- Acetylcholine receptor subunit beta
- Acetylcholine receptor subunit epsilon
- Acetylcholine receptor subunit delta
- Neuronal acetylcholine receptor subunit beta-3
Sequence:
MVQLLAGRWRPTGARRGTRGGLPELSSAAKHEDSLFRDLFEDYERWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGASTKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDRTDFFDNGEWEIMSAMGSKGNRTDSCCWYPYITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHADRYFTQREEAESGAGPKSRNTLEAALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLFVPVIYKWANIIVPVHIGNTIK
Protein: Probable delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase) (EC 1.2.1.88) (L-glutamate gamma-semialdehyde dehydrogenase) (O74766)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Probable proline dehydrogenase, mitochondrial
- Pyrroline-5-carboxylate reductase
- Probable glutamate 5-kinase
- Probable gamma-glutamyl phosphate reductase
- Aspartate aminotransferase, cytoplasmic
- Ornithine aminotransferase car2
- Aspartate aminotransferase, mitochondrial
- Probable NAD-specific glutamate dehydrogenase
- NADP-specific glutamate dehydrogenase
- Glutamine synthetase
Sequence:
MSQFAEFKLPAIKNEPPKHYGPNSADREGIVKAYKELEAELPVTIPVIIDGKEVETNTIGEQRCPFEHKKVVARYHRAGAKHVEDAIEAALRGKKVWESLPFADRSAIFLKAAHLISTKYRYKLMAATMIGQGKNIWQAEIDAGMEIIDFLRFNTKYASELYASQPPENTPGVWNRMEYRPLEGFVYAITPFNFTAIAGNLAAAPLLMGNVVLMKPSDHAVLSSYIVYQIFREAGLPAGALQFIPGDAVEVSKVCFNHPEFAGLHFTGSTAVFRSLWGTIGENVANGKYRTYPKIVGETGGKNFHLVHSSAEIKSAVVNAVRAAFEYQGQKCSALSRLYVSKYAWENGFRDELTKQVKSLKVGAPLTDFANFVGPVIHQASFNKLKKVLESAASDSEIEVLAGGKADDSEGFFVEPTVLLSKNPKHDIFVNELFGPVLSVYVYEDDNLDAVCDLIDTTTPYGLTGSIFAQDRVVVRKLTDRLRNAAGNFYINDKCTGAVVGEQPFGGARASGTNDKAGSGMILSRFVSPRSIKDTFAYADSVLYPSNF
Protein: Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (Small inducible cytokine subfamily E, member 1) (Q4G079)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Methionine--tRNA ligase, cytoplasmic
- Bifunctional glutamate/proline--tRNA ligase
- Arginine--tRNA ligase, cytoplasmic
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
- Leucine--tRNA ligase, cytoplasmic
- Glutamine--tRNA ligase
- Lysine--tRNA ligase
- Aspartate--tRNA ligase, cytoplasmic
- Eukaryotic translation elongation factor 1 epsilon-1
- Isoleucine--tRNA ligase, cytoplasmic
Sequence:
MIFCRFWGKMATNDAVLKRLEQKGAEADQIIEYLKQQVALLKEKAILQATLREEKKLQVENAKLKKEIEELKQELIQAEIHNGVKQVPVPSSSSLETHCSVSESVTRSASVTTTTMTGGGGEEKKVKEKTEKKGEKKEKKQQSAAASADSKPVDVSRLDLRIGCIVTAKKHPDADSLYVEEVDVGEAAPRTVVSGLVNHVPLEQMQNRMVVLLCNLKPAKMRGVLSQAMVMCASSPEKVEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQPDLHTNDECVATYKGAPFEVKGKGVCRAQTMANSGIK
Protein: Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Glutamine synthetase I alpha) (GSI alpha) (P12425)
Organism: Bacillus subtilis (strain 168)
Function: Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17001076}.
Interaction partners:
- HTH-type transcriptional regulator GlnR
- HTH-type transcriptional regulator TnrA
- Glutamate synthase large chain
- Glutamate synthase small chain
- Catabolic NAD-specific glutamate dehydrogenase RocG
- Glutamine--fructose-6-phosphate aminotransferase
- Nitrite reductase [NAD
- Ammonium transporter
- Assimilatory nitrate reductase electron transfer subunit
- Cryptic catabolic NAD-specific glutamate dehydrogenase GudB
Sequence:
MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGKALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGTPFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLAPTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVVKTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIAGIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEVRSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATLAEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY
Protein: Protein lin-54 (Abnormal cell lineage protein 54) (Q95QD7)
Organism: Caenorhabditis elegans
Function: Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repress transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:17075059}. Chromosome {ECO:0000269|PubMed:17075059}. Note=Localizes to condensed chromosomes during the diakinesis phase of meiosis. {ECO:0000269|PubMed:17075059}.
Interaction partners:
- Protein lin-52
- Protein lin-9
- Probable histone-binding protein lin-53
- Uncharacterized protein
- Retinoblastoma-like protein homolog lin-35
- E2F/DP family winged-helix DNA-binding domain-containing protein
- Transcription factor dpl-1
- Protein let-418
- ETS domain-containing protein
- Probable histone-binding protein rba-1
Sequence:
MNQGEIVYQDDDDYYDESEIYDNYEEGAEFIEVNGQLVPHNPNLQAQQNRPGTSSMIQQHNRSMEVNQGLVKDEPIDTSSHRVYVPPPRPVQRKLFQPGPSTPGSSQYTVRNLSNLSGSPSMYDRQPASLPRTVQPMGLEMGNSEQRKVYIDMKDHVSHIRLKTKKKVFAPGQRKPCNCTKSQCLKLYCDCFANGEFCRDCNCKDCHNNIEYDSQRSKAIRQSLERNPNAFKPKIGIARGGITDIERLHQKGCHCKKSGCLKNYCECYEAKVPCTDRCKCKGCQNTETYRMTRYKNSGGAVSNTNALMSLTNASSTATPDSGPGSVVTDEHGDDYEDMLLSHKPKVEMDPRRFPWYYMTDEVVEAATMCMVAQAEEALNYEKVQTEDEKLINMEKLVLREFGRCLEQMITNTTELTQDLDAAPTDDIPGPSTSTS
Protein: Colutellin-A (P86168)
Organism: Colletotrichum dematium (Anthracnose fungus)
Function: Has antifungal activity against S.sclerotiorum (MIC=32.4 ug/ml after 288 hours) and B.cinerea (MIC=10.8 ug/ml after 288 hours), and weak antifungal activity against F.solani, A.fumigatus and G.candidum. Lacks antifungal activity against P.ultimum, T.viride and R.solani. Inhibits the production of interleukin-2 by activated CD4+ T-cells with an IC(50) of 167.3 nM. Lacks cytotoxic activity against human peripheral blood mononuclear cells.
Subcellular location: Secreted {ECO:0000269|PubMed:18599825}.
Interaction partners:
Sequence:
VISIIPV
Protein: Anaerobic dimethyl sulfoxide reductase chain B (DMSO reductase iron-sulfur subunit) (P18776)
Organism: Escherichia coli (strain K12)
Function: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.
Interaction partners:
- Dimethyl sulfoxide reductase DmsA
- Anaerobic dimethyl sulfoxide reductase chain C
- Putative dimethyl sulfoxide reductase chain YnfE
- Probable dimethyl sulfoxide reductase chain YnfF
- Anaerobic dimethyl sulfoxide reductase chain YnfH
- Formate dehydrogenase, cytochrome b556
- Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit
- Formate dehydrogenase, nitrate-inducible, major subunit
- Formate dehydrogenase-O major subunit
- Formate dehydrogenase, nitrate-inducible, cytochrome b556
Sequence:
MTTQYGFFIDSSRCTGCKTCELACKDYKDLTPEVSFRRIYEYAGGDWQEDNGVWHQNVFAYYLSISCNHCEDPACTKVCPSGAMHKREDGFVVVDEDVCIGCRYCHMACPYGAPQYNETKGHMTKCDGCYDRVAEGKKPICVESCPLRALDFGPIDELRKKHGDLAAVAPLPRAHFTKPNIVIKPNANSRPTGDTTGYLANPKEV
Protein: Chromosomal replication initiator protein DnaA (EC 3.6.4.-) (P03004)
Organism: Escherichia coli (strain K12)
Function: Plays a key role in the initiation and regulation of chromosomal replication. Binds in an ATP-dependent fashion to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex exactly once per cell cycle. Binds the DnaA box (consensus sequence 5'-TTATC[CA]A[CA]A-3'); subsequent binding of DNA polymerase III subunits leads to replisome formation. The DnaA-ATP form converts to DnaA-ADP; once converted to ADP the protein cannot initiate replication, ensuring only 1 round of replication per cell cycle. DnaA can inhibit its own gene expression as well as that of other genes such as dam, rpoH, ftsA and mioC.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377, ECO:0000269|PubMed:22574163}. Cytoplasm, nucleoid {ECO:0000269|PubMed:22574163, ECO:0000269|PubMed:28166228}. Cell inner membrane {ECO:0000269|PubMed:22574163}; Peripheral membrane protein {ECO:0000269|PubMed:22574163}. Note=About 10% of the protein associates with the cell inner membrane (shown in strain BL21(DE3)) (PubMed:22574163). 70% of the protein oscillates between opposite cell halves in a time frame of a few seconds, independent of transcription (PubMed:28166228). {ECO:0000269|PubMed:22574163, ECO:0000269|PubMed:28166228}.
Interaction partners:
- Replicative DNA helicase DnaB
- Beta sliding clamp
- Replicative helicase loader DnaC
- DNA replication and repair protein RecF
- DNA gyrase subunit B
- DNA primase
- DnaA initiator-associating protein DiaA
- DNA polymerase III subunit alpha
- DnaA regulatory inactivator Hda
- Protein MioC
Sequence:
MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADAPQLRFEVGTKPVTQTPQAAVTSNVAAPAQVAQTQPQRAAPSTRSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
Protein: Protein ripply2 (Q5TAB7)
Organism: Homo sapiens (Human)
Function: Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
Interaction partners:
- Transducin-like enhancer protein 2
- Mesoderm posterior protein 2
- Transducin-like enhancer protein 1
- Transducin-like enhancer protein 4
- T-box transcription factor TBX6
- TLE family member 5
- Transducin-like enhancer protein 3
Sequence:
MENAGGAEGTESGAAACAATDGPTRRAGADSGYAGFWRPWVDAGGKKEEETPNHAAEAMPDGPGMTAASGKLYQFRHPVRLFWPKSKCYDYLYQEAEALLKNFPIQATISFYEDSDSEDEIEDLTCEN
Protein: Fucolectin-7 (Q9I925)
Organism: Anguilla japonica (Japanese eel)
Function: Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
Subcellular location: Secreted {ECO:0000269|PubMed:10924498}.
Interaction partners:
Sequence:
MKTCNLTDRMEVKMIMLLFQILAISTLKSDSADIPEGYIQENVALRGRATQSAQLRGDHSGIAHASNAIDGNRDSVFYHGSCTHTEADKPWWRVDLLQVYTITSVTITNRGDCCEERISGARILIGKHLENNGINNPQCSVIGPMAAGETKTFRCPQPMIGRYVTVYLPKAESLHLCEVEVNVLFPAPC
Protein: Mitochondrial import inner membrane translocase subunit Tim17-A (Inner membrane preprotein translocase Tim17a) (Q99595)
Organism: Homo sapiens (Human)
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:10339406}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial import inner membrane translocase subunit Tim23
- Mitochondrial import inner membrane translocase subunit TIM50
- Mitochondrial import inner membrane translocase subunit Tim21
- Mitochondrial import inner membrane translocase subunit TIM16
- Mitochondrial import inner membrane translocase subunit TIM14
- Stress-70 protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim10
- GrpE protein homolog 1, mitochondrial
- Mitochondrial import receptor subunit TOM40 homolog
Sequence:
MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFPNGPQFAEDPSQLPSTQLPSSPFGDYRQYQ
Protein: Oligopeptide transporter protein OPT (A4GVG6)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
VATVFACQYYNDQPQLPWWGVLLACGIAIVFTLPIGIITAITNQTPGLNIITEYIIGYIYPGYPVANMCFKVYGYISMTQAITFLQDFKLGHYMKIPPRTMFMAQIVGTLIACFVYLGTAWWLTN
Protein: Probable transcriptional regulator (Q9HVS2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable transcriptional regulator
- Probable transcriptional regulator
- Probable transcriptional regulator
- Probable transcriptional regulator
- Probable binding protein component of ABC transporter
- Probable metallopeptidase
- Dipeptide-binding protein
Sequence:
MTVDRIGERLRRYRRAAKKTLHQVASESGLTASFLSQAERNLTGVSISSLANIAKSLNIPLNALFDQPAQPQPDSHEGERVRYTIEGQPLAYERLSSSFPGNLINAVKMNMPVGYQSELISHEGAEFSYVLSGQIVYTIEGRQYPLGAGDSVHFDATKTHCLANVGSDVAEVLTITTMGLFDDHPTP
Protein: AT24563p (Q7JWS5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MENFRTSNNSGVSQRIHNTGPTPVLAPSGLRSRLLSGSSERNPNEYYGDSDSSSSSRSIDRTPFLLEYSSDSESSSSSDSESSSTSISFDSSMSSTESSTPMGHTESSDSNEDSPPNKRIKSDDEESKKSVLPYNCPVCLEDVREKLPVSTNCGHVFCKACIKRAVDTGRVCPLCGVDEPEFHRIFL
Protein: Single-minded homolog 1 (mSIM1) (Q61045)
Organism: Mus musculus (Mouse)
Function: Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00632, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Aryl hydrocarbon receptor nuclear translocator 2
- Aryl hydrocarbon receptor nuclear translocator
- Homeobox protein orthopedia
- Melanocortin receptor 4
- Pro-thyrotropin-releasing hormone
- Agouti-related protein
- Oxytocin-neurophysin 1
Sequence:
MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPTFSYTSSSTPTISDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPERPGSQHELSCAYRQFPDRSSLCYGFALDHSRLVEDRHFHTQACEGGRCEAGRYFLGAPPTGRDPWWGSRAALPLTKASPESREAYENSMPHITSIHRIHGRGHWDEDSVVSSPDPGSASESGDRYRTEQYQNSPHEPSKIETLIRATQQMIKEEENRLQLRKAPPDQLASINGAGKKHSLCFANYQQPPPTGEVCHSSALASTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPSSDRITKSSLILAKDYLHSDMSPHQTAGDHPAISPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS
Protein: 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase) (P49914)
Organism: Homo sapiens (Human)
Function: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.
Subcellular location: Cytoplasm.
Interaction partners:
- Formimidoyltransferase-cyclodeaminase
- C-1-tetrahydrofolate synthase, cytoplasmic
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
- Trifunctional purine biosynthetic protein adenosine-3
- 5-formyltetrahydrofolate cyclo-ligase
- Serine hydroxymethyltransferase, cytosolic
- Monofunctional C1-tetrahydrofolate synthase, mitochondrial
- Serine hydroxymethyltransferase, mitochondrial
Sequence:
MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA
Protein: Spermidine synthase 3 (F4KJ05)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEGDVGIGLVCQNTMDGKASNGNGLEKTVPSCCLKAMACVPEDDAKCHSTVVSGWFSEPHPRSGKKGGKAVYFNNPMWPGEAHSLKVEKVLFKDKSDFQEVLVFESATYGKVLVLDGIVQLTEKDECAYQEMIAHLPLCSISSPKNVISHLKKFSLSGFLYLVACCNKSVNLKVLVVGGGDGGVLREISRHSSVEVIDICEIDKMVIDVSKKFFPELAVGFDDPRVQLHIGDAAEFLRKSPEGKYDAIIVDSSDPVGPALALVEKPFFETLARALKPGGVLCNMAESMWLHTHLIEDMISICRQTFKSVHYAWSSVPTYPSGVIGFVLCSTEGPAVDFKNPINPIEKLDGAMTHKRELKFYNSDMHRAAFALPTFLRREVASLLAS
Protein: C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2) (P13500)
Organism: Homo sapiens (Human)
Function: Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Subcellular location: Secreted {ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:2513477}.
Interaction partners:
- C-C motif chemokine ligand 4 like 2.
- C-C motif chemokine 5
- C-C motif chemokine 8
- C-C motif chemokine 15
- C-C chemokine receptor type 5
- Interleukin-8
- C-X-C motif chemokine 9
- C-C chemokine receptor type 1
- C-C chemokine receptor type 2
- C-X-C motif chemokine 13
Sequence:
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
Protein: Argonaut-like protein (Q54G64)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Uncharacterized protein
- RNA-directed RNA polymerase
- RNA-directed RNA polymerase
- RNA-directed RNA polymerase
Sequence:
MIPKKQKGFNGEPKSHQEIDRSQSPLKQRTNNNNYQQQPPQQQQKQQPQQPQQKKQQQKQQQKQQPQQPQQPQQPQQQKQQLQQPQQPQQYFQPRQTQNAWGKQNNSIPLEEQFQEVKPITQPQTPETTTTTTTTTTTTTNTTNTNLLVPRISRRDMVKDSDIENVAIVTAKSRTVQGKQISLISNFFPIVISDRKSLEFRIDFNPPQVTFDKRRKLIRELLSLNNISKEFYFYDGDSILYSPINININSQSIDGVQIFIRKVKEVNHRDKSSVNSQFFNIITKNNMRKMGFSLIGRNYYSPINKIKFEDYLLEVWKGFSTSVVSTESGTMLLADTSSKVVRSETVLDRIKYLRYDKDRCFDEIINSIVLTRYNNKTYRISNISWSSGVNDKMDGTTTFLQYYQRNYPNHKITDYRQPLLKSEVKFRGIKQTIFLIPELTFLTGLSDHMRKNFKLMAELAKHSNFDPSQRYQTLSNFISDINNNPKVSKSLEPWGITYQPALKVDGYVLSAPKNLPNDNKRQLNNIKWAFVVDRDEYERTRDCQTNLYNFINETGMSQPTTICYTDPRDKRPIQYSNIMENAIKTHGIQFFLMLIPQNQPEIYKEIKRKSLVQFKVLTQCIFPRTFYKGRSVTNKLKQQVIAKLGYAPWGLNQQIFNGVIPKKTMIIGIDVGHNSDMRGHSVVGFVATIDDKFQKYFSRSFVQKRPGKEIIDSLEEATKEAMSKYFSFNNCLPELVIVYRDGVGDGMLDLVNRSEIAAMKKGFAETPSSWGIKPKLMYVIVKKNTNARLFTADPIGNPPAGTLVDSKITHPNWYDFFLVSQVTNNGSVNPTHYHVLLDEQKMPADLFQLFTFQMCHLYFNFEKSVRVPATCQFAHKMAFLIGRTVFADAAPQLSDKLFFL
Protein: MAP kinase-activated protein kinase mak-1 (MAPK-activated protein kinase mak-1) (EC 2.7.11.1) (Q21360)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin.
Subcellular location: Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:25851606}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000269|PubMed:25851606}. Note=Localizes between and around dense bodies. Colocalizes with myosin heavy chain unc-54 at the outer edge of A-bands. {ECO:0000269|PubMed:25851606}.
Interaction partners:
- SHSP domain-containing protein
- MAP kinase-activated protein kinase mak-2
- ER membrane protein complex subunit 7 homolog
- C3H1-type domain-containing protein
- Mitogen-activated protein kinase pmk-2
- BZIP domain-containing protein.
- Mitogen-activated protein kinase pmk-3
- Heat shock transcription factor hsf-1
- CTD small phosphatase-like protein 1
- Mitogen-activated protein kinase pmk-1
Sequence:
MMFEYEEDEDPMEQQKHEEFKHHSTDHSGSPQENPFRFSYDTGKRAASMFVTPSSEDLIAYGTKHLLDSPTAVQRSLVLNATTSLNIDCDLSSDDDLSPTTQRKICFCASQNPAETQEQGLRPAKSTLAISFPCHQHQITEDYTISAEIIGIGESGKVMACYQKVTGEKFALKVLRDSQKARREVELHWLTNAHENVVSILDIYENTFDNVKCLLMVVEFLEGGDLLSQFESQGSIPYTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDNCVYKLGDYGFAKRPERNVLMESPCCTPFYAPPEVLGRERYDKSCDMWSLGVAMYILLCGYPPFYSMKGVALSPGMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLTIHELMATPLVTGEPIVPGKHITTAIAIPGADESECGGGVFDDGFIVEEEETPDTVAEILPVPKSVRFLRDGVKAPRLHSIQEEVGRAMEIMRMGTDQVYIKNPTASCNNLFERRRAVHLSIPRVYC
Protein: Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13) (O94829)
Organism: Homo sapiens (Human)
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- SUMO-conjugating enzyme UBC9
- GTP-binding nuclear protein Ran
- Eukaryotic translation initiation factor 1A, X-chromosomal
- RNA-binding protein 8A
- Protein mago nashi homolog
- Protein mago nashi homolog 2
- Exportin-4
- BAI1-associated protein 3
- BTB/POZ domain-containing protein KCTD2
- Paired box protein Pax-6
Sequence:
MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY