wanglab/gogpt-training-data huggingface dataset:
Protein: NLR family member X1 (Caterpiller protein 11.3) (CLR11.3) (Nucleotide-binding oligomerization domain protein 5) (Nucleotide-binding oligomerization domain protein 9) (Q86UT6)
Organism: Homo sapiens (Human)
Function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species. Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313, ECO:0000269|PubMed:27393910}.
Interaction partners:
- Mitochondrial antiviral-signaling protein
- Elongation factor Tu, mitochondrial
- TNF receptor-associated factor 6
- Autophagy-related protein 16-1
- Antiviral innate immune response receptor RIG-I
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Autophagy protein 5
- Interferon-induced helicase C domain-containing protein 1
- Ubiquitin-like protein ATG12
- Inhibitor of nuclear factor kappa-B kinase subunit beta
Sequence:
MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSAPPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSLTEGTAVSEYWSVILSEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVEGEVRALLEQLGSSGS
Protein: MHC class II alpha chain (MHC class II antigen O region alpha locus) (Q31150)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MVLFVELVPVLLTVMSFLSPRGVRAIKADHMGSYGPAFYQSYDASGQFTHEFDGEQIFSVDLKNEEVVWRLPEFGDFAHSDFQSGLMSISMIKAHLDILVERSNRTRAVSVPPRVTVLPKTRVELGKPNVLICIVDDIFPPVINVTWLRNSQPITKGVAQTSFYSQPNHRFRKFHYLTFVPSAEDVYDCKVEHWGLDTPLLQHWEPQVLTPPPDTTETLICGLGLVLGLMGCLLGTVLMITGTRRPSIRR
Protein: Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)] (Q9EQT1)
Organism: Rattus norvegicus (Rat)
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis (By similarity). May play an important role in control of lens epithelial cell proliferation. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
Subcellular location: Secreted {ECO:0000250}. Note=Released by platelets upon wounding. {ECO:0000250}.
Interaction partners:
- Platelet-derived growth factor receptor beta
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor subunit A
- Platelet-derived growth factor subunit B
- Platelet-derived growth factor C
- Pro-epidermal growth factor
- Insulin-like growth factor 1
- Receptor protein-tyrosine kinase
- Insulin-2
- Insulin-1
Sequence:
MHRLILVSILVCANFCCYRDTFATPQSASIKALRNANLRRDESNHLTDLYRRDENIRVTGTGHVQSPRFPNSYPRNLLLTWRLHSQEKTRIQLAFDHQFGLEEAENDICRYDFVEVEDVSESSTVVRGRWCGHKEIPPRITSRTNQIKITFQSDDYFVAKPGFKIYYSFVEDFQPEAASEINWESVTSSFSGVSYHSPSVMDSTLTADALDKAIAEFDTVEDLLKYFNPASWQDDLENLYMDTPRYRGRSYHERKSKVDLDRLNDDVKRYSCTPRNHSVNLREELKLTNAVFFPRCLLVQRCGGNCGCGTLNWKSCTCSSGKTVKKYHEVLKFEPGHFKRRGKAKNMALVDIQLDHHERCDCICSSRPPR
Protein: pyridoxal kinase (EC 2.7.1.35) (O51709)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Interaction partners:
- tRNA N6-adenosine threonylcarbamoyltransferase
- Divergent polysaccharide deacetylase superfamily
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- RNA polymerase sigma factor
- Flagellar P-ring protein
- Uncharacterized protein
Sequence:
MKRILAMHDISSMGRTSLTICIPVISSFNMQVCPFVTAVLSASTAYKKFEIVDLTDHLEKFINIWKEQNEHFDILYTGFLGSEKQQITIEKIIKLIKFEKIVIDPVFADDGEIYPIFDNKIISGFRKIIKYANIITPNITELEMLSKSSKLNNKDDIIKAILNLDTKATVVVTSVKRGNLLGNICYNPKNKEYSEFFLEGLEQNFSGTGDLFTSLLIGYLEKFETEQALEKTTKAIHLIIKESIKENVSKKEGVRIENFLKNTF
Protein: Growth hormone (Q0QBH2)
Organism: Ovis aries (Sheep)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Interaction partners:
Sequence:
MMAAGPRTSLLLAFTLLCLLWTQVVGTFPAMSLSRLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTGKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDVTPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (A0A0G2K2W0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Catenin beta-1
- Cadherin-5
- Pleiotrophin
- Adhesion G protein-coupled receptor F5
- Angiopoietin-1 receptor
- Insulin-like growth factor-binding protein 2
Sequence:
MTILTCLILGSLEGFQIVHVRKQQCLSINQKVIMSSCNGTSHNQQWLSTENGKFLHVKSGLCLSISNSSGGPFRPAVATPCAQAPRWTCHAQGGFLEVDNTSLFLKKQNRKVVVRKISKYLDSWMKLELNKEGRLVNESLCLKQAGLGTEVSVRITRNSAAPQIPTTSNTISYNPDHISNITETFLGSTAKTLGSTTETLRSTAETLGSTAEPYSQSSSKRDLPSLHMAGTTDTSWSPSTTPPFSSTTAETGVAEQVKCNFTVLESKVSSLSASIQWRTFGSPCNFSLIYSSDTSGPLWCHPILIDNFTYGCDPKDLQAGTIYNFRIVSLDGEERSLVLQTDPLPPARLEVNPERTTSTTLQVRWTPSSGKVTWYEVQLFDQNNQKIQEVQVQESATWSQYTFLNLTAGSSYKIGITAVSGGKRSFPVYTNGSTGPSPVEDIGISPNPNSLLISWSRGPGNVEQFRLMLMDKGAIVQDTNVDKRDTSYAFRGLTPGHLYNVTIVTMASGLQNSRWKLGRTAPMEVSNLKVTSGGSLTSLNVKWQKPLGVIDSYSITLSHQGTVKESKTLPPRATEIQFKDLVPGRFYQVTIRCVSGELSAEKSAMGRTVPEKVSNLVSYNEIWMKSFAVNWTPPAGDWDHYRILLFNDSLVLLNTTVGKEETHFALEGLELIPGRQYEVEVIVESGNLRNSERCQGRTVPLAVLQLRIKQANETSLGITWRAPLGEWEKYTISLMDRELFVIHKSLSKDAKEYTFTNLMPGRNYKATVTSMSGDLKQSASIQGRTVPAQVTDLEVSNQGMTSSLFTNWTKALGDVEFYQVLLIHENVVVKNESVSSDSSWYSFRALRSGSLYSVVVTTVSGGIPSRQVVAEGRTVPSSVSGVTVNNSGRNDYLSVSWLPAPGEVHHYVVTLSHDSKVVQSLITAKFVSECSFSSLTPGRLYNVTITTKSGNYESHSFSEERTVPDKVQGISVSNSARSDYLKVSWVHATGDFDHYEVTIKNRDSFIQTKSIPKSENECVFARLVPGRLYSITVTTKSGQYEASEQGTGRTIPEPVKNLTLLNRSTEDLHVTWSRANGDVDQYEVQLLFNDMKVFPPIYLVNTATEYQFSALTPGRHYKILVLTISGDVQQPAFIEGLTVPSTVKNIHISANGATDRLTVTWSPGGGDVDSYVVSAFRQDEKVESHTLPKHGSEHTFHRLEAGATYRIAIVSVSGSLRNQIDVLGQTVPASVHGVVADNAYSSNSLTVSWQKALGMAERYDILLLSENGVLLSNTSEPATVKQHKFEDLTPGKKYKMQILTVSGGLFSKEVETEGRTVPAAVTNLRITENSSRHLSFSWTASEGELSWYNIFLYNPDKTLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPAAVNHLKGSNRNMTDSLWFSWSPASGDFDFYELILYNPNGTKKENWREKDVTEWRFQGLIPGRKYTLYVVTHSGDLSNKVTGEGRTAPSPPSLLSFADVANTSLAITWKGPPDWTDYNDFELQWLPGDALTVFNPYSSKKSEGRIVNGLRPGRSYQFSVKTVSGDSWKTYSKPISGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEIEFSRKLEKEKSLLNIMMLVPHRRYLVSIKVQSAGVTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFAVVVREADSMDELRPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAESPDPDRSSKSFNIKLGGEMDSLGGKCDPSQQKFCDGPLKPHTAYRISIRAFTQLFDEGLKEFTKPLYSDTFFSMPITTESEPLFGVIEGVSAGLFLIGMLVALVAFFICRQKASHSRERSSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEDLKDVGRSQSCDIALLPENRGKNRYNNILPYDASRVKLCNVDDDPCSDYINASYIPGNNFRREYIATQGPLPGTKDDFWKMAWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDPLYYGDLILQMVSESVLPEWTIREFKICSEEQLDAHRLLRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFVALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRNEQENPLFPIYENVNPEYHRAQQGLYERLSLTFLF
Protein: Cald1 protein (Q7TMN5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEAHVQNSVPDEESKPASSNTQVEGDEEAALLERLARREERRQKRLQEALERQKEFDPTITDGSLSGPSRRMQNDSAENETAEGEEKRESRSGRYEVEETEVVIKSYQKNSYQDAEDKKKKK
Protein: Ferritin (EC 1.16.3.1) (B8A405)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVKLIASLLLLAVVAQAYGDFKSKQESKSFVRELQREREEHQLKEKQNLSHEGQDQECKGSLAVPEITKDWVDMKDACIKGMRNQIQEEINASYQYLAMGAYFSRDTVNRPGFAEHFFKAAKEEREHGSKLVEYLSMRGQLTEGVSDLINVPTVAKQEWTDGAAALSDALDLEIKVTKSIRKLIQTCENKPYNHYHLVDYLTGVYLEEQLHGQRELAGKLTTLKKMMDTNGELGEFLFDKTL
Protein: Homeobox protein Ved (Ventrally-expressed dharma/bozozok antagonist) (Q8AV71)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Dharma.
- Ligand of Numb protein X 2b isoform X1
- Chordin
- Homeobox protein goosecoid
Sequence:
MKGQFSIEWLSQSSSSVRDEQQTSSTSTDSLPGSYSRWTSPHMEKHMEEKYTEEKYLQEKSMEKFMHEKYTEEKHMPEKYTEGKRIQKHTHESGFSSSTEDEELSGCESEGSRSEGSGSRSPAAPGSVAPASGSGSPSSGRRPRTAFSSEQISSLERVFKRNAYLGAQDKAELCRTLKLTDKQIRNWFQNRRMKLKRTVQDSLAQACQVKVASHMMHYSDLHSFRAAPYPSFYPETPAAFAPPYPISPAAESLYYSSYQNLQGVPSIPVHPYQYYSTH
Protein: Oxygen-evolving enhancer protein 3-1, chloroplastic (OEE3) (16 kDa subunit of oxygen evolving system of photosystem II) (OEC 16 kDa subunit) (Q9XFT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for photosystem II assembly/stability and photoautotrophic growth under low light conditions.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:11719511, ECO:0000269|PubMed:18431481}; Peripheral membrane protein {ECO:0000269|PubMed:11719511}; Lumenal side {ECO:0000269|PubMed:11719511}. Note=Associated with the photosystem II complex.
Interaction partners:
- Oxygen-evolving enhancer protein 1-2, chloroplastic
- Oxygen-evolving enhancer protein 1-1, chloroplastic
- Oxygen-evolving enhancer protein 2-1, chloroplastic
- Putative oxygen-evolving enhancer protein 2-2
- Photosystem II 10 kDa polypeptide
- Chlorophyll a-b binding protein CP26, chloroplastic
- Expressed protein
- Photosystem I reaction center subunit psaK, chloroplastic
- Photosystem II protein D1
- Photosystem II CP43 reaction center protein
Sequence:
MASMGGLHGASPAVLEGSLKINGSSRLNGSGRVAVAQRSRLVVRAQQSEETSRRSVIGLVAAGLAGGSFVQAVLADAISIKVGPPPAPSGGLPAGTDNSDQARDFALALKDRFYLQPLPPTEAAARAKESAKDIINVKPLIDRKAWPYVQNDLRSKASYLRYDLNTIISSKPKDEKKSLKDLTTKLFDTIDNLDYAAKKKSPSQAEKYYAETVSALNEVLAKLG
Protein: Candida glabrata strain CBS138 chromosome D complete sequence (Q6FW69)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome G complete sequence
- Nucleoporin NSP1
- Candida glabrata strain CBS138 chromosome G complete sequence
- Candida glabrata strain CBS138 chromosome G complete sequence
- mRNA export factor GLE1
- chitinase
- Candida glabrata strain CBS138 chromosome J complete sequence
- Candida glabrata strain CBS138 chromosome C complete sequence
- Nuclear pore complex protein Nup85
- Candida glabrata strain CBS138 chromosome G complete sequence
Sequence:
MKFTTTFLLTFMSISTSIFANAQKGFLTDIQVFDTHSGSNNSTDPSHWFLIQGQVFVPQDAKNSIPFTVPDEFDSFPSGDFPLSYNSKIIGSINKADDSNNFDIQLVDSNILQNVSTTFNFLCKLSSKGLSEIRSPGSVSYTFTNGDNVEFVRNINYLATDPTKINTNGGIYQTNNTAWFTLDIPISQFKRPIRIQSTPSVPNAYQFDASKTTFKVVTKLNKFNQPLATVPLTAVHDYSTNSKIDVLFNSSFSGGEYVRITYYSSQLYSKTISNNLNISYPANDLSKRDVVDPSEININTNLYAAPLDNLSHINVSTPNPDVSKNSTMTPLPAYTNGTASNVTKSLEVIPTYSLDHSTVSAIVSEYGVWIPVSTLNGTTSSKMMIQSKIVRNDTTTSTPTATPTSRPDEFTNSTSSSSSIMYHNSTITTISSSQTDYSSAATSSSISSSTSKFTNTTTTQSLKQTVTKTVCPTCEKADNETQLSTIASVYQSTISEQLSEYEFLEAASTIQSTKQTSSTKASTSSKVKSTELSVSEQVYYSTKPASKSVYGDLEAVSTLSSKSSNSVAHSVEVSASKSLSTKSAVVTDIGVLEPVSTLKSSSSPKPTNNIVSGKVETTSTAPAIISLYTSVQASTLSTVHPGNTTTSHVVSIYQGGSSSLTIQFSTIIIGFIALLL
Protein: Thrombospondin-4 (P35443)
Organism: Homo sapiens (Human)
Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Z1T2}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q9Z1T2}. Secreted {ECO:0000250|UniProtKB:Q9Z1T2}. Secreted, extracellular space {ECO:0000250|UniProtKB:Q9Z1T2}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9Z1T2}.
Interaction partners:
- Leukocyte surface antigen CD47
- Platelet glycoprotein 4
- Syndecan-1
- Integrin beta-3
- Cyclic AMP-dependent transcription factor ATF-6 alpha
- Integrin beta-1
- Syndecan-4
- Integrin alpha-V
- Integrin alpha-3
- Integrin alpha-IIb
Sequence:
MLAPRGAAVLLLHLVLQRWLAAGAQATPQVFDLLPSSSQRLNPGALLPVLTDPALNDLYVISTFKLQTKSSATIFGLYSSTDNSKYFEFTVMGRLNKAILRYLKNDGKVHLVVFNNLQLADGRRHRILLRLSNLQRGAGSLELYLDCIQVDSVHNLPRAFAGPSQKPETIELRTFQRKPQDFLEELKLVVRGSLFQVASLQDCFLQQSEPLAATGTGDFNRQFLGQMTQLNQLLGEVKDLLRQQVKETSFLRNTIAECQACGPLKFQSPTPSTVVPPAPPAPPTRPPRRCDSNPCFRGVQCTDSRDGFQCGPCPEGYTGNGITCIDVDECKYHPCYPGVHCINLSPGFRCDACPVGFTGPMVQGVGISFAKSNKQVCTDIDECRNGACVPNSICVNTLGSYRCGPCKPGYTGDQIRGCKAERNCRNPELNPCSVNAQCIEERQGDVTCVCGVGWAGDGYICGKDVDIDSYPDEELPCSARNCKKDNCKYVPNSGQEDADRDGIGDACDEDADGDGILNEQDNCVLIHNVDQRNSDKDIFGDACDNCLSVLNNDQKDTDGDGRGDACDDDMDGDGIKNILDNCPKFPNRDQRDKDGDGVGDACDSCPDVSNPNQSDVDNDLVGDSCDTNQDSDGDGHQDSTDNCPTVINSAQLDTDKDGIGDECDDDDDNDGIPDLVPPGPDNCRLVPNPAQEDSNSDGVGDICESDFDQDQVIDRIDVCPENAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTQTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVKSKTGPGEHLRNSLWHTGDTSDQVRLLWKDSRNVGWKDKVSYRWFLQHRPQVGYIRVRFYEGSELVADSGVTIDTTMRGGRLGVFCFSQENIIWSNLKYRCNDTIPEDFQEFQTQNFDRFDN
Protein: Uncharacterized protein (Q582H8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRASAAVRCILSSTTLTSQITQLVQRAEQHLKVKPANPCSLDTSSTPVADNLWEQVMAVAPSARALKETDTLLALVFRLLRSGLQPPSGEAATETWSALIRDLAPYSDVEANSVLSYPGTPECAEELGGAMANALCAAEGRNNSNCDLDDRPLLRLTRETLLLTGGVVPLSARVPCSDGGAIGQLLDAFCVCCEASGNAMMSSASLEEMSKAVLSALHVIAETVDVRETSPLVLSLLRFMRLLGVREKGQYKQNDESMGSVASFAEELTSVLANNGLGARIVLFFVHEHCEATPEEMVPLPLVCLAARGIWRHYRTADTTFPCLEHLKYVNGAVDVTLQRNANSNNILGLQENEEGDLRLQVSLALLRGMRLHADSPDVFLRSAIDVVDSCPASLSLEYEVLVAKTNLLDMFADDEASCSAIYDDLLQSLRALVELRPRDAENDVSSMNTHEGGEGDAASDGKVTRKKKLQIKHMEEDRQLLREQFQEAHRIVVEAFVRSRIQERLNQAYTILVTHKYHGLVITQEVAYPLLDVLSRRGDCRVFNIIDLCVLYSGCTIDYDALTCLFRACRVAGDFYRARTLYQLLKEMIPGFLLRAPTTIREMLRELKVVDPEPTHLFADTLLGNGTMGGAECPANILPVELIDEDDPSNRRRGPLRELPSAKAE
Protein: HTH-type transcriptional regulator RutR (Rut operon repressor) (P0ACU2)
Organism: Escherichia coli (strain K12)
Function: Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).
Interaction partners:
- Ureidoacrylate amidohydrolase RutB
- Putative carbamate hydrolase RutD
- PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM
Sequence:
MTQGAVKTTGKRSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKAFREDFAPLAAIKEYIRLKLEVSRDYPQASRLFCMEMLAGAPLLMDELTGDLKALIDEKSALIAGWVKSGKLAPIDPQHLIFMIWASTQHYADFAPQVEAVTGATLRDEVFFNQTVENVQRIIIEGIRPR
Protein: rRNA-processing protein FCF1 homolog (Q9CTH6)
Organism: Mus musculus (Mouse)
Function: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y324}.
Interaction partners:
- KRR1 small subunit processome component homolog
- WD repeat-containing protein 46
- Nucleolar protein 58
- Something about silencing protein 10
- Ribosomal RNA small subunit methyltransferase NEP1
- Probable U3 small nucleolar RNA-associated protein 11
- BMS1 homolog, ribosome assembly protein
- U3 small nucleolar ribonucleoprotein protein IMP3
- Small subunit processome component 20 homolog
- Small ribosomal subunit protein uS4
Sequence:
MGKQKKTRKYATMKRMLSLRDERLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKFRVALRIAKDPRFDRLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYLSNHRYNIERMPDDYGAPRF
Protein: Uncharacterized protein F21D5.5 (Q19683)
Organism: Caenorhabditis elegans
Interaction partners:
- transketolase
- GHMP kinase N-terminal domain-containing protein
- Inositol monophosphatase ttx-7
- Transcription termination factor 2
- Restriction endonuclease
- Cadherin domain-containing protein
- Uncharacterized protein
- Telo_bind domain-containing protein
- Transcription termination factor 2
- DNA ligase IV
Sequence:
MKRAMDGAKNEAKKSKDTDLFGRPLKKTGSWESKDNGDLMIFTHSECEGKEKIAAFDMDGTLIKTKSGKVFPTNCQDWQLLYDSIPSDFKKLHSDGFKIVIFTNQKGIHAGKVDRNEFRKKIEAIVGKLGIPVQAFVSVAGGHYRKPCVGMWNELKLRNDEVEINEKESIFVGDAAGRIKTTSRPKKDHSYADRFFAANVGVKFQTPEEFFGKSKVDEPWGPPNFDPKNLFSEEITELEPHDAQLKSSEKEIILMVGFPGSGKSTFAKMLGHQHDYKIVNRDTIGTWQKCVAATRSYLADGKSVVIDNTSPDLESRKRYIDVAKELGVPIRCFEMNCSMEHAQHNIRFRVLTDDNAAEISSMVLRIHKGKYVEPTLSEGFSQIVKVNFRPKFEVEEHEKLYKMYLIE
Protein: HTH tetR-type domain-containing protein (Q7DA42)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MTRSDRPYRGVEAAERLATRRRQSLSAGLDLLGSDQHDIAELTIRTICRRAGLSVRYFYESFTDKDEFVGRVFDWVVAELVATTQAAVTAVPAREQTRAGMANIVRTITADARVGRLLFSTQLANAVITRKRAESSALFAMLSGQHAVDTLHAPANDHVKAVAHFAVGGVGQTISAWLAGDVRLDPDQLVDQLAALLDELTDPNLSRPRVAATAAKSGANDPQPPEVAGQPPSSARPARRS
Protein: protein-serine/threonine phosphatase (EC 3.1.3.16) (Q6P3I6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Zinc finger protein 710
- PHD finger protein 20, b
Sequence:
MESSIITQVQREDTRLSSKTDQVNKSSPQKPGSRNIFKKLICCLRAQDAQLPTSPTHDALLEPEDNGTFAKIPGESLLPAVTSHDQGKICVVIDLDETLVHSSFKPISNADFIVPVEIEGTTHQVYVLKRPYVDEFLQRMGELFECVLFTASLAKYADPVTDLLDQCGVFRTRLFRESCVFYQGCYVKDLSRLGRELHKTLILDNSPASYIFHPENAVPVLSWFDDSEDTELLHLIPVFEELSQAEDVYSRLQQLRAP
Protein: Thyroid peroxidase (TPO) (EC 1.11.1.8) (P14650)
Organism: Rattus norvegicus (Rat)
Function: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Thyroglobulin
- Tyrosine 3-monooxygenase
- Tyrosinase
- Aspartate aminotransferase, cytoplasmic
- Thyrotropin receptor
- Aromatic-L-amino-acid decarboxylase
- Aspartate aminotransferase, mitochondrial
- Amine oxidase.
- Amine oxidase
- Amine oxidase
Sequence:
MRTLGAMAVMLVVMGTAIFLPFLLRSRDILGGKTMTSHVISVVETSQLLVDNAVYNTMKRNLKKRGVLSPAQLLSFSKLPESTSGAISRAAEIMETSIQVMKREQSQFSTDALSADILATIANLSGCLPFMLPPRCPDTCLANKYRPITGVCNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSSRTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDSGRAYLPFASAACAPEPGAPHANRTPCFLAGDGRASEVPALAAVHTLWLREHNRLATAFKAINTHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVNPTVSNVFSTAAFRFGHATVHPLVRRLNTDFQDHTELPRLQLHDVFFRPWRLIQEGGLDPIVRGLLARPAKLQVQEQLMNEELTERLFVLSNVGTLDLASLNLQRGRDHGLPGYNEWREFCGLSRLDTGAELNKAIANRSMVNKIMELYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENSHVFTDAQRQELEKHSLPRVICDNTGLTRVPVDAFRIGKFPQDFESCEEIPSMDLRLWRETFPQDDKCVFPEKVDNGNFVHCEESGKLVLVYSCFHGYKLQGQEQVTCTQNGWDSEPPVCKDVNECADLTHPPCHSSAKCKNTKGSFQCVCTDPYMLGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLSWTVICRWTHADKKSTLLITERVTMESGFRKSQESGISPQKAEVQDAEQEPAYGSRVLLCE
Protein: Ejaculatory bulb-specific protein 2 (Ejaculatory bulb-specific protein II) (PEB-meII) (Q23982)
Organism: Drosophila melanogaster (Fruit fly)
Function: Protein component of the posterior mating plug.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Ejaculatory bulb-specific protein 1
- Accessory gland-specific peptide 57Da
- Accessory gland protein Acp36DE
- Accessory gland-specific peptide 26Aa
- Serpin 77Bb
- Accessory gland protein 98AB
- ACP24A4
- ACP53C14A
- Accessory gland-specific peptide 70A
- ACP53C14B
Sequence:
MIRILVLMITFTLMTGSALCSIEQLMRVFGGGSVGGGSRLDINRRVTIVPPEGELSFGYGFRPGFY
Protein: Adipocyte-related X-chromosome expressed sequence 2 (C0HK80)
Organism: Mus musculus (Mouse)
Function: Plays a role in adipogenesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21177646}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MNSLLSRANSLFAFTLSVMAALTLGCILTTAFKDRSAPVRLHVSRILLKKVEDFTGPRKKSDLGFITFHISADLEKTFDWNVKQLFLYLSAEYSTKSNAVNQVVLWDKILLRGENPKLNLKDVKSKYFFFDDGHGLKGNRNVTLTLSWQVIPIAGILPLVTGSGRVSVPFPDSYEIATTF
Protein: G-protein coupled bile acid receptor 1 (Membrane-type receptor for bile acids) (M-BAR) (Q80T02)
Organism: Rattus norvegicus (Rat)
Function: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Bile acid receptor
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2
- Guanine nucleotide-binding protein G
- Actin-related protein 2/3 complex subunit 1B
- Actin related protein 3B
- Actin-related protein 3
- Free fatty acid receptor 2
- Actin-related protein 2/3 complex subunit 5
Sequence:
MMSHNTTELSAIPRGVQELSLVLASLIVIANLLLALGIVLDRHLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNRSHQGYWSCLLLHLAPNFCFLSLLANLLLVHGERYMAVLQPLRPHGSVRLALFLTWISSLLFASLPALGWNHWSPGANCSSQAIFPAPYLYLEVYGLLLPAVGATALLSVRVLATAHHQLREIRRLERAVCRDAPSTLARALTWRQARAQAGATLLFLLCWGPYVATLLLSVLAYERRPPLGPVTLLSLISLGSASAAVVPVAMGLGDQRYTAPWRTAAQRWLQVLRGRPKRANPGPSTAYHSSSQCSTDLDLN