wanglab/gogpt-training-data huggingface dataset:
Protein: Clathrin light chain A (Lca) (P09496)
Organism: Homo sapiens (Human)
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge.
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21297582, ECO:0000305|PubMed:15858577}. Note=Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles. {ECO:0000305}.
Interaction partners:
- Clathrin heavy chain 1
- Clathrin heavy chain 2
- Clathrin light chain B
- AP-2 complex subunit alpha-1
- Unconventional myosin-VI
- AP-2 complex subunit beta
- AP-2 complex subunit sigma
- AP-2 complex subunit mu
- AP-2 complex subunit alpha-2
- AP-1 complex subunit sigma-1A
Sequence:
MAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQPHGEPPGGPDAVDGVMNGEYYQESNGPTDSYAAISQVDRLQSEPESIRKWREEQMERLEALDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKANNRVADEAFYKQPFADVIGYVTNINHPCYSLEQAAEEAFVNDIDESSPGTEWERVARLCDFNPKSSKQAKDVSRMRSVLISLKQAPLVH
Protein: Calaxin (Q8T893)
Organism: Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Interaction partners:
- UPF0691 protein C9orf116-like
- Armadillo repeat-containing domain-containing protein
- Armadillo repeat-containing protein 4
- Tektin
- DC2-related axonemal dynein intermediate chain 5
- Outer dynein arm-docking complex subunit 4
Sequence:
MSKKNQKLAEELYKTSCQKHFTKTEVESLIICYKNLLEGLKMDRNLFRDILHQKFNMTEDLLMDRVFRAFDKDSDSYISLTEWVEGLSVFLRGTLDEKMEYTFTVFDLNGDGYISREEMFQMLKTCLVKQPTEEDPDEGIKDLVEIALKKMDHDHDSRLSKKDFKDAVLIEPLLLEAFGKCLPDEKSSEIFEYHVLGVKQCRG
Protein: Alpha-ketoglutarate dependent kainoid synthase (Alpha-KG dependent kainoid synthase) (EC 1.14.11.-) (Domoic acid biosynthesis cluster protein C) (PmDabC) (A0A386KZ95)
Organism: Pseudo-nitzschia multiseries (Marine planktonic diatom) (Nitzschia pungens f. multiseries)
Function: Iron/ascorbate-dependent oxidoreductase: part of the gene cluster that mediates the biosynthesis of domoic acid (DA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins causing amnesic shellfish poisoning (ASP). Catalyzes the conversion of 7'-N-carboxy-L-geranyl-L-glutamic acid (cNGG) to isodomoic acid-A. Mediates also the conversion of N-geranyl-L-glutamic acid (L-NGG) to dainic acid A.
Interaction partners:
Sequence:
MTVAINNETVVLTPNEDDVQVNKGKTLETSFPPLKGDDLKWFPRSSLPAEIPAIDIGKVSTKEELEQFLVDIRKSGLFYIVNHGVPEEVSINVYNAFREFISTTTEEERMKYYTDTHFQNGGYVPFQGSSIRGGNLGKPQKDHVVKYFWRGPEVINRTPNEKFTEAHNMHHTETFKVAEKVIRTIFKALKLRFPDFDPMEFENTINSKKMFFTNRIYPQAEPSDEEEITHRLVPHLDTSFITLANQVPADNGFQGLFVETGDGKKVKVPGIRNSYLVFIGQSLSYLTKNYLPSALHGVDKPPSDLFEGSERSSLITFYEPAEIIIPSKNINPNPEETSESCPFFYDIGLTVNDPEGTTWDFVKNKFITGYYAD
Protein: Conserved protein (O53749)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- HTH-type transcriptional regulator RamB
Sequence:
MTGQNGQVARISPGKFRQLGPVNWLVAKLAARAVGAPQMHLFTTLGYRQYLFWTFAIYTGRLLHGRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLDANTQATIFAWPDVPDGDGPRKVLSARQQALLQATDELIKDRTITAGTWERLATHLDPRLLIEFCLLATQYDAIAATITALAIPPDNPQ
Protein: Poly(A) binding protein, cytoplasmic 4 (V9GXG3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVMKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKV
Protein: Uncharacterized protein (Q57UK0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Ribosomal protein S23 mitochondrial conserved domain-containing protein
- Trans-sialidase
- Uncharacterized protein
- Uncharacterized protein
- Rhodanese domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MLRCARVALRADPLNGGSSMTLGSKGSKLSPEPHRRRMPWTAAKEYVPGVVLNARDKMVLDGVQLLDIESIDRASQLDPLEVLRAVVATREYNISTGKNIFQLASQATYNGRGQRFYRKEWQEGTYDKYVTLSAIDFDRDGNKGTAYGYITFHGETTTRPVQVDFADVPGWYMDFVEERAVPFTGIVPPPPSIGTDVPVDPHSYRLKAYPYYDAPNPPEFVERLLKDRGVLPDTPTETADVDKDPTTSDGSVHYDGK
Protein: Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30] (Q03157)
Organism: Mus musculus (Mouse)
Function: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Subcellular location: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [C30]: Cytoplasm. Note=C-terminally processed in the Golgi complex.
Interaction partners:
- Amyloid beta precursor protein binding family B member 1
- Beta-secretase 1
- Major prion protein
- Contactin-5
- Amyloid beta precursor protein binding family B member 2
- Nicastrin
- Amyloid-beta precursor protein
- Spondin-1
Sequence:
MGPTSPAARGQGRRWRPPPLPLLLPLSLLLLRAQLAVGNLAVGSPSAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLLDPQRVLEYCRQMYPELHIARVEQAAQAIPMERWCGGTRSGRCAHPHHEVVPFHCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPATPNPSGMAAGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEEERAPPPSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEIGEHEGFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQGDPPQAERVLMALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVQTHLQVIEERMNQSLGLLDQNPHLAQELRPQIQELLLAEHLGPSELDASVPGSSSEDKGSLQPPESKDDPPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHSSDIQRDELAPSGTGVSREALSGLLIMGAGGGSLIVLSLLLLRKKKPYGTISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
Protein: Probable cyclic nucleotide-gated ion channel 20, chloroplastic (Cyclic nucleotide-binding transporter 1) (Q9LD37)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable cyclic nucleotide-gated ion channel.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Membralin-like protein At1g60995
- Glutamate receptor 3.3
- RING/FYVE/PHD zinc finger superfamily protein
Sequence:
MASHNENDDIPMLPISDPSSRTRARAFTSRSRSVSLSNPTSSIEGFDTSTVVLGYTGPLRTQRRPPLVQMSGPLTSTRKHEPLFLPHPSSDSVGVSSQPERYPSFAALEHKNSSEDEFVLKHANLLRSGQLGMCNDPYCTTCPSYYNRKAAQIPTSRVSALFDSTFHNALYDDAKGWARRFASSVNRYLPGIMNPHAKEVQTWTKFFALSCLLAIFIDPLFFFLIKVQEQNKCIMIDWPMTKAFVAVRSVTDVIFTMNILLQFRLAYVARESTVVGAGQLVSHPKKIALHYLKGKFFLDLFIVMPLPQILILWIIPAHLGASGANYAKNLLRAAVLFQYIPKLYRLLPFLAGQTPTGFIFESAWANFVINLLTFMLAGHVVGSCWYLFGLQRVNQCLRNACGNFGRECQDLIDCGNGNSSVLVRATWKDNASANACFQEDGFPYGIYLKAVNLTNHSNLFTRYSYSLFWGFQQISTLAGNQVPSYFLGEVFFTMGIIGLGLLLFALLIGNMQNFLQALGKRNLEMTLRRRDVEQWMSHRRLPDGIRRRVREAERFNWAATRGVNEELLFENMPDDLQRDIRRHLFKFLKKVRIFSLMDEPILDAIRERLKQRTYIGSSTVLHRGGLVEKMVFIVRGEMESIGEDGSVLPLYEGDVCGEELLTWCLERSSVNPDGTRIRMPSKGLLSSRNVRCVTNVEAFSLSVADLEDVTSLFSRFLRSHRVQGAIRYDSPYWRLRAARQIQVAWRYRRRRLHRLCTPQSSYSL
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q7JQ39)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MESNIYLVFLLTFLLYNNARAEISDHLREDIPDLDMELSSASSAHLNGKELPAVPQNSVQTHPRYKCYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWLQNPDVRLPALRIKKTIHKLASADEKIRLDFDEVCV
Protein: Boundary element associated factor (Boundary element-associated factor of 32kD, isoform B) (Boundary element-associated factor of 32kD, isoform C) (LD44361p) (Q94513)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00371}.
Interaction partners:
Sequence:
MPKGRVSNVWQHYDINEECENFAICRYCGNNISRGGMASNLKGNNTTNLWTHLRHKHRDEVLVSPVQQRPQARMIPIIKKDKTVRITKAKTLREPLRVAKPKIESNVANYLGEAGALPQKWEEYEQNDEISEDIKDIIYSEDPLCYSPIHVMDDEGLDQPEKQVTVLTHSTSPAGGSSRPIGVGSGVQATVVASTSSSSSSAKQLKNNLETSIERLTAVSEQLSYIIQQNHEELTKDDDYYFALSLVPAMRHLSLSRKMYVRSKIQDILFKESEDSTLAKDE
Protein: Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) (P80192)
Organism: Homo sapiens (Human)
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Interaction partners:
Sequence:
MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS
Protein: Mitotic checkpoint protein BUB3 (O43684)
Organism: Homo sapiens (Human)
Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Subcellular location: Nucleus. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. {ECO:0000250}.
Interaction partners:
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Cell division cycle protein 20 homolog
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Cell division cycle protein 27 homolog
- Mitotic spindle assembly checkpoint protein MAD2A
- Anaphase-promoting complex subunit 4
- BUB3-interacting and GLEBS motif-containing protein ZNF207
- Outer kinetochore KNL1 complex subunit KNL1
- Mitotic spindle assembly checkpoint protein MAD1
- Cell division cycle protein 23 homolog
Sequence:
MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYEMDDTEHPEDGIFIRQVTDAETKPKSPCT
Protein: Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (Peptide:N-glycanase 1) (yPNG1) (Q02890)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. Involved in the formation of free oligosaccharide in cytosol.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- UV excision repair protein RAD23
- Carboxypeptidase Y
- Cell division control protein 48
- E4 ubiquitin-protein ligase UFD2
Sequence:
MGEVYEKNNIDFDSIAKMLLIKYKDFILSKFKKAAPVENIRFQNLVHTNQFAQGVLGQSQHLCTVYDNPSWHSIVLETLDLDLIYKNVDKEFAKDGHAEGENIYTDYLVKELLRYFKQDFFKWCNKPDCNHCGQNTSENMTPLGSQGPNGEESKFNCGTVEIYKCNRCGNITRFPRYNDPIKLLETRKGRCGEWCNLFTLILKSFGLDVRYVWNREDHVWCEYFSNFLNRWVHVDSCEQSFDQPYIYSINWNKKMSYCIAFGKDGVVDVSKRYILQNELPRDQIKEEDLKFLCQFITKRLRYSLNDDEIYQLACRDEQEQIELIRGKTQETKSESVSAASKSSNRGRESGSADWKAQRGEDGK
Protein: Teashirt homolog 2 (Ovarian cancer-related protein 10-2) (OVC10-2) (Zinc finger protein 218) (Q9NRE2)
Organism: Homo sapiens (Human)
Function: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MPRRKQQAPKRAAGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPGSHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLRPTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFADSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQSLSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGPLKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSVLNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHALSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQERMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEISRVSSAQRSPETIAAEEDTDSKFKCKLCCRTFVSKHAVKLHLSKTHSKSPEHHSQFVTDVDEE
Protein: Cryptochrome-like protein (Q2TV23)
Organism: Gallus gallus (Chicken)
Interaction partners:
- Basic helix-loop-helix ARNT-like protein 1
- Circadian locomoter output cycles protein kaput
- Timeless circadian regulator.
- F-box and leucine rich repeat protein 3
- Period circadian protein homolog 2
- Cryptochrome-2
- Period circadian clock 3
- Neuronal PAS domain-containing protein 2
- Iron-sulfur cluster assembly 1 homolog, mitochondrial
- Casein kinase I isoform epsilon
Sequence:
MRHRTIHLFRKGLRLHDNPALLAALQSSEVVYPVYILDRAFMTSSMHIGALRWHFLLQSLEDLRSSLRQLGSCLLVIQGEYESVVRDHVQKWNITQVTLDAEMEPFYKEMEANIRGLGEELGFQVLSLMGHSLYNTQRILELNGGTPPLTYKRFLRILSLLGDPEVPVRNPTAEDFQRCSPPELGLAECYGVPLPTDLKIPPESISPWRGGESEGLQRLEQHLADQGWVASFTKPKTVPNSLLPSTTGLSPYFSTGCLSVRSFFYRLSNIYAQAKHHSLPPVSLQGQLLWREFFYTVASATPNFTKMAGNPICLQIRWYEDAERLHKWKTAQTGFPWIDAIMTQLRQEGWIHHLARHAAACFLTRGDLWISWEEGMKVFEELLLDADYSINAGNWMWLSASAFFHHYTRIFCPVRFGRRTDPEGQYIRKYLPILKNFPSKYIYEPWTASEEEQKQAGCIIGRDYPFPMVDHKEASDHNLQLMKQAREEQHRIAQLTRDDADDPMEMKLKRDHSEESFTKTKAARMTEQT
Protein: DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (topoI) (O17966)
Organism: Caenorhabditis elegans
Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Required for normal spermatogenesis and oogenesis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P11387}. Nucleus, nucleolus {ECO:0000269|PubMed:16943775}. Chromosome {ECO:0000269|PubMed:16943775}. Note=Localizes around sperm chromatids. {ECO:0000269|PubMed:16943775}.
Interaction partners:
- DNA topoisomerase 2 top-2
- Probable tyrosyl-DNA phosphodiesterase
- Crossover junction endonuclease MUS81
- DNA topoisomerase 3
- Small ubiquitin-related modifier
- Ribonuclease H2 subunit A
- DM2 domain-containing protein
- Putative DNA topoisomerase 2, mitochondrial
- DNA topoisomerase-like protein cin-4
- FACT complex subunit spt-16
Sequence:
MSVVSNHHSNGNGNSTVYDTNGNDEIKKEVKDEPMASDSEVPFGELMKRDKKEKKQKKRKAESGSDEDDYKPEKRKSSAKNGKKKDVGSDSEDDYKPEKKKSKKNNKKKAQESSEDDDEESEGDVSEEDVKPQIHSDDELEEEDEAPTTDDEEEQKRKEKERRKKEKREKKERKEKKRLEKENRKIKEEDDEDSDDEDDEKAKKKKRKSKGAEKSKPSTSKKDAGGKKEPPKKKVKKEEDIEDIWEWWKEEKKPAGVKWNSLQHCGPLFAPPYIPLPSHVHFKYGGEKMKLTLETEEIAQFYAGVLDHEYSTKEAFNKNFMKDWRKVMTVEERERIHDLKKCDFRAIDAYQKEQREIRKAMTKEEKLKIKEEKEAEVKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKMGLIKKRIMPEDVIINCGKDTEIPKPPPGHKWKEVRHDNTVTWLCSWTESVLGQNKYIMLNPSSKIKGEKDFEKYETARRLKKKIGGIRERYTDDFKSKEMRVRQRATALYFIDKLALRAGNEKDVDEAADTVGCCSLRVEHIKLFDSAKLNEDDKKEKEFVVEFDFLGKDSIRYFNRVSVEKRVYKNLKIFMEGKAPSDDLFDRLDTATLNDHLRSLMDGLTVKVFRTYNASITLQEQLIKLTNPKDNVAAKILSYNRANRQVAILCNHQRAVSKGFDESMQKLEQKIKDKKKEVKEAEAALKSARGAEKEKAQKKYDRLKEQLKKLKISRTDKDENKQIALGTSKLNYIDPRITVAWCKKFEVPLEKVFTKTHREKFRWAIDMTNSSDEEYVF
Protein: Nuclear autoantigenic sperm protein (NASP) (Q66HD3)
Organism: Rattus norvegicus (Rat)
Function: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q99MD9}. Nucleus {ECO:0000250|UniProtKB:Q99MD9}.
Interaction partners:
- Histone acetyltransferase type B catalytic subunit
- ASF1 anti-silencing function 1 homolog B
- Anti-silencing function 1A histone chaperone
- RB-binding protein 4, chromatin-remodeling factor.
- RB binding protein 4, chromatin remodeling factor like 1
- Histone-binding protein RBBP7
- Ubiquitin protein ligase E3 component n-recognin 7
- Integrator complex assembly factor WDR73
- DNA replication licensing factor MCM7
Sequence:
MATESTATAAIAAELVSADKVEDAPAPSTSADKMESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAEGQSLTKPETDKEQESEVEKGGREDMDISEPAEKLQEKVESTSKQLTESSEEAKEAAIPGLNEDEVTSGKTEQESLCTEEGKSISGVYVQNKEFREAVPQEEGEEMISLEKKPKETSEDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDVGGEEPKDQGAISESELGKAVLMQLSGQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNGPVVGQSSAGDQTPSEPQNSAERLSETKDGASVEEVKAELVPEQEEAMPPVEESEAAGDGVETKVAQRATEKAPEDKFKIAANEETQERDEQMKEGEETEGSEEEDKENDKAEETTNESVLEKKTLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLLEQMKEAEGSFTEYEKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKPEPEVNGGSGDAVSSGNEVSENMEAEAENQAESQTTAEGTVDSAATVKSTAC
Protein: Uncharacterized protein (Q38B64)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MMQNGFVLILFHLLLSVVPPGRGVEWEGSSDDQKHGSHHQFFNVSENERLLSKLRLPFRLSLTSVKETTDLAREVVFLQRVGGMCPRLDMWERVEVLFGIGTPLEEKYGVERLELVQALLEPAVIRFHEDDLETVSDPLGFIGLMVQGQGTVIWVHFSELVVSHMVGQPPSLNVNVVAVFQRVERWAKKTRLNRHRLQMEAEYARVRSEHLIAIDHDRHKMKEEATERRRRKEFLRDLREFNKQNSQGTVHHNKGLENAGLSDDGAAVREQIGTRCENIRHAIRTVKSQGVPTTETRMQYLLKKEGRVCVTPLEEEDSNLTDADVCDIRCLAYCDGVSALHNWSERSGSSNSVSQLHALYHTVLFNRTNSSMSVSNDYLSYLRQLVMEDVERGVFSTCSDICSPSPSLRKEMNFFAGVLALLDNGGMRNKTAQKVKLARVDSEWWFRARSGYLRIWAAARSGSERALKALATMRENGMLTPQQSRMALIFLHVSLAQDKSSIWNIAAETLTAPRGSSFSIPMGKLLRTERFFGMENSWSAVNEPYMTRSYVGAVGVEADGGNDDEREGALYYAPSQSVQRDIFIAKLYIAGIKGVQRDMQRAECLLLTILRKLEYTCDVEHAASEDEVYFSGGGRGGGCEEHMDQLRVLRYKLPALGRCRFSTTGNNTASASRTEALLRFGGMSWSEESFPLLHDTLLLLSYIHLVDGLKFNLSAKYAFQAIQLGAAAFHTALRSIPEAVVAEFYAYRNNSERLKVLMRGRKPPASSLLMHAMRRGEPRDDLEDFTRSGFLTSEALLLLAVAAPQLGAEGEQLMRVVAESFYGSASCVEHPSRSSCVIQLSFFLLREAARLWKDEEREPSVFDSSYGSPHRADPFLLMALLLQKGKITVEDIRQGSVFNKALYAPSTSHVLRPTAADTRDSYVSKILKLARQTSPYILKPIARENSKNGRRFMDNSTTLREFQATRLAIQRSLHEHDILPLLVVSDLHDYLYENGWTRIQRFLGNLWDTICAPFTKLKEEYLEEQFAEEVISEKQGGNALTTIAEKLAESISASNSVREGSIALQLLSAALLSGEPDGFSILLTEEMDRKNQHLSSFAVFLSEHLWCRGTITGVWVEEHKAAQWHDKKPKTRGYGALFDVNTQAPFDYTLSESRLEMFALLALKRALSRQASTSHGDVISSSANRSLSQEEVDKSVGELALCGGVLIGTFLEKQRPFPPHKPYEGMHLPVGNSRCLRQLLKHIEITGVSPFKGISAAEVEIWLLNTLVSFTELQSKYYTISLLGRYRGLSSKKEEWEGRRLRKRLVEPWRRVNGEEWTEMWVPDVGEGAVYNRRLHDISGTYLGARVKWFFKNVIFYGSHLLRWFW
Protein: Heavy metal transport/detoxification superfamily protein (B3H4A8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAEKGKEKVTMMKLKVDLDCAKCYKKVKKVLCKFPQIRDQLFDEKSNIVIIKVVCCSPERIMDKLCSKGGGSIKTIEIVEPPKPPQPQPQQPPQKPKDAQPKAPEKPKEPEKPKQPEKLKEPEKPKQPEKPKEPEKTKQPAPAPAPAPAPAAKPAPAPAPAPAPAPKQPGPPPQAIPMMPQGQPAMCCGPYYDGYGGPAFNGYGMPPQPYECYGRPVYESWGGGCPPPPPAYRQCHVTRCDYFSEENPQSCSIM
Protein: RH23273p (Rab23) (Q9VNG6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein smoothened
- ADP-ribosylation factor-like protein 3
- Suppressor of fused homolog
Sequence:
MRLIQTATGGAAASVLQTHSQAQYNYTSMREDDIELAIKVVIVGNGGVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIEIDGEDVRIMLWDTAGQEEFDCITKAYYRGAQASVLVFSTTDRASFDAIKDWKRKVENECNEIPTVIVQNKIDLIEQAVVTADEVETLAKLLNCRLIRTSVKEDINVASVFRYLATKCHQLMTQSYDQVAGNQQNSSHPPYSSTPTISAFSPTFTKSSSGTIVLRPAKKGHGSSVARKRKIVLKKCGIL