wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q382V3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNAKSSCLVGTTNRSNFEFVCPEENVDVTQLGNPTNGTLAPANNGNVSSEAEANVGMIENDLPTSWVVLSRSCRIADGSPHTPQEGSRPDHQEDEKGESTQQEMEQHAEIQECSMRSSLEHRTTTLTSSWFGTCNSSLHADIERSEVGPTTPFNPSWHSTCTENNTVEASDNSQPADATLSSIEDLRRSNDILRALLAQSDKVVAQSLLGKEAAARELGDMRSTLSALLANTESRSNIFRGPRSRRLHQPAVPEQSEPPNENQPFHLFGWLQQFLFGDSERESQDSGSSQREQEDHTHTDEHFDILDSPLPLRGGFSWRSHFDTARRCAQRGRNQEAFASLLLGITSEDFCEWNLLLEENEKCNFLSGPHRLRWDCIIADKLCEFLWSDKVVEVNGTLPHEEPVTPNPERPNPVAIADFVLGTIARHFGNGRTDGQMSQEMPSAGADGGSDSEDRTRNSLGTQQPSPPSPGPPFRTLENILSIATSIFPSDVSLLYAQASLCAVLGRQEDSIRLLNEVIVREPGCLLRYGGCGVKQ
Protein: Uncharacterized protein C191.05c (Q9Y7P9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MTGTAKVSIPKAQPHKVPCVYLAGDLVFRPNAIELFDELKEICKDAGVQGVAPFDGQEGVEEMAPGAETSLKIAELDRKLMDRCDGGIFCLDPFRRAPDMDPGTAVELGYMAAQGKPLAGFTTDGRMYPEKVRSYRKQAWGDALKPRFTKGGSGSMEDADGLIVHSEGFLQNVMTEGFIRMSGGFVAVDFSIQEAFRTAIKDLAARLNSQH
Protein: Global transcriptional regulator CodY (Q0SSB9)
Organism: Clostridium perfringens (strain SM101 / Type A)
Function: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
Interaction partners:
Sequence:
MSTLLSKTRRLNKILQKSGTEAIAFGDICQLLSDVMSCNVYLVGRKGRILGYSFSEKFECDIMKEKVVVDRKFPEDYNNKLINIQDTIANIPNKGICVFEGVGECLISKKISTIVPIVGNGDRLGTLLLARFGEEFNDDDLVLAEYSATIVGMELLRARQGEIEEEARKKAVVQLAIGTLSYSELEAVEHIFSELNGDEGLLVASKIADKVGITRSVIVNALRKFESAGVIESRSLGMKGTHIKILNEKLMDELKKIK
Protein: ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein (A1Z7A6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable GTPase-activating protein (GAP) for Arf family proteins (Probable). Involved in Golgi apparatus organization by targeting Arf1 to the Golgi, which may be important for membrane trafficking during epithelial morphogenesis. Regulates the positioning of interommatidial precursor cells during compound eye morphogenesis together with Arf6 and Cindr. Required for cleavage furrow ingression in early embryonic cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21976699, ECO:0000269|PubMed:27535433}. Nucleus {ECO:0000269|PubMed:27535433}. Cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:21976699, ECO:0000269|PubMed:27535433}. Cell projection, microvillus {ECO:0000269|PubMed:27535433}. Note=Detected in large puncta at the plasma membrane (PubMed:21976699, PubMed:27535433). Excluded from the nucleus at interphase (PubMed:27535433). Enriched in the nucleus at prometaphase (PubMed:27535433). {ECO:0000269|PubMed:21976699, ECO:0000269|PubMed:27535433}.
Interaction partners:
- Rab11
- LD21953p
- Exocyst complex component 7
- LD44762p
- ADP-ribosylation factor 6
Sequence:
MPPSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGNTHVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDEDRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVRRVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRPYHFQAEDEGDQKAWMAVLVNCKEKALTKAFQHANPQMSPSLVELQKTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLGRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQFTLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQSDLGGHVTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPRHSQNFDASDIRAINHKNQSLDVAYGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNNSLMPAMTTFGHKRSPSGESLNRNIHLAGAKLVLPPTGELPTLKHVDKSALTRPKIPPPGPPSEREISNGQSNESISSMDEGPVAPPRKLVNQSANFPDYESWHTDMDSSGGGLDHSAESNVSSSDNDRLNSSPDNPSKTGGAGLGGKFHYNGQRRCRALYDCVADNDDELEFKEGEILIVLNERTDDENWMEGIIEGQPTRKGMFPVSFVHMLPD
Protein: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip) (Q8LB02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14671022}; Peripheral membrane protein {ECO:0000269|PubMed:14671022}; Matrix side {ECO:0000269|PubMed:14671022}.
Interaction partners:
- Succinate dehydrogenase flavoprotein subunit 2, mitochondrial
- Succinate dehydrogenase flavoprotein subunit 1, mitochondrial
- Succinate--CoA ligase subunit alpha-1, mitochondrial
- Fumarate hydratase 2
- Succinate--CoA ligase subunit alpha-2, mitochondrial
- Fumarate hydratase 1, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
- L-aspartate oxidase, chloroplastic
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- Succinate dehydrogenase subunit 3-2
Sequence:
MAFGLIGRVVGTKSSRLSTAARLIPARWTSTGSEAQSKASTGGGGASLKTFQIYRWNPDNPGKPELQDYKIDLKDCGPMVLDALIKIKNEMDPSLTFRRSCREGICGSCAMNIDGCNGLACLTKIESGSKETTITPLPHMFVIKDLVVDMTNFYNQYKSIEPWLKRKNPASVPGKEILQSKKDRAKLDGMYECILCACCSTSCPSYWWNPESYLGPAALLHANRWISDSRDEYTKERLEAIDDEFKLYRCHTILNCARACPKGLNPGKQITHIKQLQKSG
Protein: Modulator of apoptosis 1 (MAP-1) (MmMOAP1) (Q9ERH6)
Organism: Mus musculus (Mouse)
Function: Retrotransposon-derived protein that forms virion-like capsids. Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (By similarity). Required for death receptor-dependent apoptosis (By similarity). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins. Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96BY2}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96BY2}. Extracellular vesicle membrane {ECO:0000269|PubMed:34413232}. Note=Forms virion-like extracellular vesicles that are released from cells. {ECO:0000269|PubMed:34413232}.
Interaction partners:
- Ras association domain-containing protein 1
- Ras association domain-containing protein 6
- Ras association domain-containing protein 7
Sequence:
MTLRLLEDWCRGMDMNPRKALLVAGIPPTCGVADIEEALQAGLAPLGEHRLLGRMFRRDENKNVALIGLTVETGSALVPKEIPAKGGVWRVIFKPPDTDSDFLCRLNEFLKGEGMTMGELTRVLGNRNDPLGLDPGIMIPEIRAPMLAQALNEALKPTLQYLRYKKLSVFSGRDPPGPGEEEFESWMFHTSQVMKTWQVSDVEKRRRLIESLRGPAFEIIRVLKINNPFITVAECLKTLETIFGIIDNPRALQVKYLTTYQKTDEKLSAYVLRLEPLLQKLVQKGAIEKEVVNQARLDQVIAGAVHKSVRRELGLPEGSPAPGLLQLLTLIKDKEAEEEEVLLQAELEGYCT
Protein: Small ribosomal subunit protein uS15 (40S ribosomal protein S13) (M0RCY2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS2
- Ubiquitin-ribosomal protein eS31 fusion protein
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein uL4
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
Sequence:
MGHMHAPSKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKLAKKGLTPSQIGVILRDSHGVAQVRFVTRNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA
Protein: Wor4p (Q5ADX8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- White-opaque regulator 3
- White-opaque regulator 2
- Adhesion and hyphal regulator 1
- White-opaque regulator 1
- Zinc cluster transcription factor CZF1
- Transcription regulator
Sequence:
MSSDKPEQEILDPKDSKNASLNSTTKKSQDSKLMLPPLGVKSEQQQPQQQQQTPLYGQQGSPQVQTQPQFQADYSYANYQPQAQFYDPYQRQVIMQQANFASPSQYPIQQPYSFANGMTNMAQFHPQTLTSHSDFDQQQMQQSTQPSQQVQVQVQIQPQSNSNSFPAEQKRGRRFRRRFNQIERKYPCSFPGCQKSYGSLNHLNTHIVTKKHGHRKSKADFQHSLQSKEENKPSEISQYVQPSNDYTAGNYWYGYAPHLRSTTSTTSSQSDSFNSQQIPQQPQQQQQQQPQQQNNSNNYLYYQGFQQPITNATTVSGATPATSTLTPAGTASASLSHQPQIQNPASASTVPQQRMVMGNMGYYQQQGAPQYFPAPQQSLLGINDVDSRNQIDDNKPTQPGI
Protein: Zinc finger protein 667 (Q5HYK9)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc finger protein 470
Sequence:
MPSARGKSKSKAPITFGDLAIYFSQEEWEWLSPIQKDLYEDVMLENYRNLVSLGLSFRRPNVITLLEKGKAPWMVEPVRRRRAPDSGSKCETKKLPPNQCNKSGQSICQKLVSAQQKAPTRKSGCNKNSVLVKPKKGHSGKKPLKCNDCGKTFSRSFSLKLHQNIHTGEKPFECSNCRKAFRQISSILLHQRIHSGKKSHECNKCGESFNQRTTLILHMRIHDGKEILDCGKALSQCQSFNIHQKIHVVGNVCQCRKCGKAFNQMSSLLLHKKIHNGKKTHKYNKCGRGFKKKSVFVVHKRIHAGEKIPENAKALSQSLQQRSHHLENPFKCRKCGKLFNRISPLMLHQRIHTSEKPYKCDKCDKFFRRLSTLILHLRIHNGEKLYRCNKCEKVCNRHSSLIQHQKVHTKKKKLFECKECGKMFSGTANLKIHQNIHSEEKPFKCNKCSKVFGRQSFLIEHQRIHTGEKPYQCEECGKAFSHRISLTRHKRIHTEDRPYECDQCGKAFSQSAHLAQHERIHTGEKPYTCKTCGKAFSQRTSLILHERSHTGEKPYECNECGKAFSSGSDLIRHQRSHSSEKPYECSKCGKAYSRSSSLIRHQNTHSEEKA
Protein: Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105) (Q9NQ35)
Organism: Homo sapiens (Human)
Interaction partners:
- Protein DDI1 homolog 1
Sequence:
MFYSGLLTEGGRKETDMREAASLRQQRRMKQAVQFIHKDSADLLPLDGLKKLGSSKDMQPHNILQRRLMETNLSKLRSGPRVPWASKTNKLNQAKSEGLKKSEEDDMILVSCQCAGKDVKALVDTGCLYNLISLACVDRLGLKEHVKSHKHEGEKLSLPRHLKVVGQIEHLVITLGSLRLDCPAAVVDDNEKNLSLGLQTLRSLKCIINLDKHRLIMGKTDKEEIPFVETVSLNEDNTSEA
Protein: Neuroendocrine secretory protein 55 (NESP55) [Cleaved into: LHAL tetrapeptide; GPIPIRRH peptide] (Q792G6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Secreted {ECO:0000250}. Note=Neuroendocrine secretory granules. {ECO:0000250}.
Interaction partners:
- D
- D
- 5-hydroxytryptamine receptor 7
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Adenylate cyclase type 9
- Adenylate cyclase type 8
- Adenylate cyclase type 2
- Guanine nucleotide-binding protein subunit gamma
- Corticotropin-releasing factor receptor 1
Sequence:
MDRRSRAHQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQRAAQRRSFLNAHHRSAAAAAAAQVLPESSESESDHEHEEAEPELARPECLEYDQDDYETETDSETEPESDIQSETEFETEPETEPETAPTTEPETEPEDERGPRGATFNQSLTQRLHALKLQSADASPRRAQPTTQEPESASEGEEPQREPLDEDPRDPEESEERREANRQPRRCKTRRPARRRDQSPESPPRKGPIPIRRH
Protein: Uncharacterized protein C9.11 (Q9UT17)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MDSANKNTKIFAEQLGNDFTISVDDEDMEMEYPLRSSTPTKVIDDQREILLQKASRISKLDEALCELNNESNGSIDLSIDSFIPSYDEFLHKKLLNEDTGHESKVSDQVKQVISTPMSTCFEQWFEGEEQSSTGNNQDISYSSVNSLSPKRRGISLMSIDANKLSPKKTSPNSGYITSPLRHPILLSETEPGTPTKNDSPAYIGLPSQPNSITTLNNTNQKFQVPDNDKPPMSSLNELSASYKPIVFDSSQHKTQGTDNNDSFYHDDTNCIHLSRLEKIRELLTFVQLELKYYVEPLKKELQETKTLLAQKEEEISNLKDKLQNAGLS
Protein: DOCK family protein (Q86I66)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- AP-3 complex subunit delta
- RasGTPase-activating protein
Sequence:
MEGKKVSTFLKSRKSTGGSSMNLTGSSNSQTLPTSMSSSSPNSSILSQSISSASSSTSSISNGGGGSSGNVSVSNSTSDLAQYNENYQKRNTRQIPSILLEDEIEKEEDYPFDFERYYYESKEINREVSRELVVIPDDATQNQIENLPKENRIKSNPFDYKENKNQHIDDCIKFYSNNTWKSLKTFNYYKNETPGAIVHQLTEERIEFKTEPIVNINNLNSNVNISISQAQKIASEAALEAKLAPQQQTPQQQQMAALQFQQQQNLKEVNYLSQQHQFQIQNTLKTDKPDKLHLHYLERQFRKEKVLINSNNNNNNNNNNENNNGENNNNSNNNNNNNNGENNNTEFGLYSYFTLSEPTVQYQEPTPYQKEKKRIIQVTFKDLSFKFWDGDDEPEPFYCSMYLYDIQKKARLSETFYFDFINDKSFKMTTSHITTSSGASSKDVVVDDVTLAKSAIFNVTARSSSELENIYLILKVEKVLTGDLEDHSEPYIKMNLKEKEKDKFKESIKSSCTRLGAFRQAFCWGCVPVFEEGVGEDTPIRPLYRHRSEMTDSSMLDSTLSEGSKSASAKKLKIIPGQCLVDIKEILPNDQQSPYLNNKKFILNSSLIKIDLPQLDQQQQQSTTTTTQNSTEQNNNNINQPGKIPSNIGIENIIKECHEFSSNQRFEINTEFVNNLYLYPETLNLSNRSGSFAARNLTCKIQLLETDENPLCPEGLKAIYGKSKTQSFNSKAYTQVTYHSKTPVFNDEIKIRLPLSPSPSLHILFTFYHIACQKSSGGGDLVDQPVAYGVLPIIQYGKMIGEEVFNLPLAYEFPSRYTRRDQEATIKYIDNKKPIFQVRSKLVSSIHSTDDYLNSFFNNISQFSFINNCLASPSLSPTPTSTPSVTSPSILTSPTISSQNLSNSNNNNNNNSTTTTTTTTTTTTNISPSNSTMEQLIKSIKLLPSSKLECIIQFFPILMNQLFRLMTNQQHSSELSMVTFITIGEILSMVNDVGSTISDRYVKYVFSNVNNQAGSNIEFLPTYEVLIKTWLELVRFQEQNSENILRFSRFFFQVIHKSMALSLIERNKREENKTRKGRFVGVRPQLAKLISILRWESSTRAKHTFKLAKELIRSLAGFISCLVSIADRGYVFKIIDRAVNDFTHNNQIGGENEMEIYELKFEFLRIICQNDYFVQLNIPLPFRIDSTSKLTNILTSSKHFLSDLLLNNISAGIGSKIPLIRMDAANSLRDTLTRLEMDTRWFDQSNKQRIVGVFTPYLTIVVNNWDNIKDDSFIMKRNILVSFIYLLKTIHINLIKIWWREEPKAKYVTLFDILNQCLEIFEFVGKEILMDKVESSTSLRTSTAKSILEDFYSNSRNSPYGSKKLYNRSLREKRVDSRKSVLENNYSNNNNVGSSNNNNNNVSGSPSSSTILINSTSNSNLLSTSFVTSSGGGSGSGYSSKSSGSSGSSGGSLIESTSTSSLNGSGSGYQNQNNNSNYSPSTTRDVSSGSGTLRNEKRMKSTLAQNKINISDYDDRLESHLALEVGSVVLDVVDEFMCEYDRDLKTTHYFDVIEKIFNLLHSMLKKNQPVQLVPKLYATLRQFIYRFPKILFENNNSFCLDLCNAVIRHCNSVNQTTREEASAFTYILFRKNFEQTKKNFVRTKTQVTIGLSTIVKSINDDYFLKKSLDTINSYAYAQADKAGTKSFSKQIEDLTKRLHTFVIDNIKINNHRDDPEMVADLYHRIADNNKSNADTRICWLQGLADFHRTQENYVEAAQCYLHMSSLVAEYLSLIGKPIPTINGSNNFMAINKNSLEESHTFIEREEDGADDNQSFTLDFFLKLVQEAILLLKESEYFEIANLVYKLLLPVHEEHLNYQELARCHGDLQDIFKRIVECTNTQSRMLGSYYRVGLYGKRFEEMNGKEFIYKEPKITRLVEIKDRLKSLYSKKLSVPEDSIVIIEGSTVDISSIEQDAAKCYLQITSVVPYFTEEELVGRRTPFDRIVHLNRFIFETPFIESGAGRANSIAEQYKRKTILKTSNYFPYTKKRISVISKQEVILSPIENSIETIDQRTETISNEVRSKVPNPKTLQQVLQGTLRLQVNIGPQEICRVFLATDPTSGAYNYPLEQIKKLKKSLSLFLGSCSEALFINKGLVENQSSQEFQEEMEQGYIQLTDLMESLGVLPPEGSYYPTLNSNSNGTSSNNNLSNSSIYGSSNNFGGSGSPVIQLNSSMINNTGSSSGNNTPTKSHNRNSSNPNRNSTGSGSTISLENDDDSNFNNLLSTSHVSRKSFTQRLSSGFKSD
Protein: Protein ORANGE-GREEN, chloroplastic (CmOr-green) (DnaJ-like cysteine-rich domain-containing protein Or) (A0A0D3MU35)
Organism: Cucumis melo (Muskmelon)
Function: Involved in chloroplast differentiation in fruit flesh.
Subcellular location: Plastid, chloroplast membrane {ECO:0000305|PubMed:25754094}.
Interaction partners:
Sequence:
MDRVLVASYPINHLIRPHSFRIDYCWSTCFTSRLNSGKERQKLSSRWRWRSMASDSTDSSSSSSFAPSVESDPSDKTSASFCIIEGPETVQDFAKMELQEIQENIRSRRNKIFLHMEEVRRLRIQQRIKNAELGISKEERENELPNFPSFIPFLPPLSSENLKLYYVTCYSLIAGIILFGGLLAPTLELKLGLGGTSYEDFIRSVHLPMQLSQVDPIVASFSGGAVGVISALMVVEVNNVKQQEHKRCKYCLGTGYLACARCSNTGALVLIEPVSTLNGEHQPLSLPKTERCQNCSGSGKVMCPTCLCTGMAMASEHDPRIDPFD
Protein: AHNAK nucleoprotein (G5E8K8)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEKEEETTRELLLPNWQGSGSHGLTIAQRDDGVFVQEVMQNSPAARTGVVKEGDQIVGATIYFDNLQSGEVTQLLNTMGHHTVGLKLHRKGDRSPEPGQTWTHEVFSSRSSEVVLNTVQPSSLDCNDQNKPKEAINKAGAASDSTPDAGL
Protein: Zinc finger protein 569 (Q5MCW4)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription intermediary factor 1-beta
- Zinc finger-containing ubiquitin peptidase 1
- Polyubiquitin-C
- Ubiquitin carboxyl-terminal hydrolase 5
- Ubiquitin carboxyl-terminal hydrolase 44
- Ubiquitin thioesterase OTU1
- OTU domain-containing protein 7A
Sequence:
MTESQGTVTFKDVAIDFTQEEWKRLDPAQRKLYRNVMLENYNNLITVGYPFTKPDVIFKLEQEEEPWVMEEEVLRRHWQGEIWGVDEHQKNQDRLLRQVEVKFQKTLTEEKGNECQKKFANVFPLNSDFFPSRHNLYEYDLFGKCLEHNFDCHNNVKCLMRKEHCEYNEPVKSYGNSSSHFVITPFKCNHCGKGFNQTLDLIRHLRIHTGEKPYECSNCRKAFSHKEKLIKHYKIHSREQSYKCNECGKAFIKMSNLIRHQRIHTGEKPYACKECEKSFSQKSNLIDHEKIHTGEKPYECNECGKAFSQKQSLIAHQKVHTGEKPYACNECGKAFPRIASLALHMRSHTGEKPYKCDKCGKAFSQFSMLIIHVRIHTGEKPYECNECGKAFSQSSALTVHMRSHTGEKPYECKECRKAFSHKKNFITHQKIHTREKPYECNECGKAFIQMSNLVRHQRIHTGEKPYICKECGKAFSQKSNLIAHEKIHSGEKPYECNECGKAFSQKQNFITHQKVHTGEKPYDCNECGKAFSQIASLTLHLRSHTGEKPYECDKCGKAFSQCSLLNLHMRSHTGEKPYVCNECGKAFSQRTSLIVHMRGHTGEKPYECNKCGKAFSQSSSLTIHIRGHTGEKPFDCSKCGKAFSQISSLTLHMRKHTGEKPYHCIECGKAFSQKSHLVRHQRIHTH
Protein: Voltage-gated potassium channel KCNC4 (Potassium voltage-gated channel subfamily C member 4) (Voltage-gated potassium channel subunit Kv3.4) (Q8R1C0)
Organism: Mus musculus (Mouse)
Function: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Ubiquitin-like protein FUBI
- Voltage-gated potassium channel KCNC1
- Voltage-gated potassium channel subunit beta-1
- Voltage-gated potassium channel subunit beta-3
- Voltage-gated potassium channel subunit beta-2
- Potassium voltage-gated channel subfamily E member 3
Sequence:
MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGGGAGPGDEAGDDERELALQRLGPHEGGSGPGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIHRVGNITSVRFRREVETEPILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPPQLESPIYCKSEETSPRDSTYSDTSPPAREEGVVERKRADSKQNGDANAVLSDEEGAGLTQPLALAPTPEERRALRRSGTRDRNKKAAACFLLSAGDYACADGSVRKEGNVEPKACVPVSHTCAL
Protein: Uncharacterized protein, isoform C (M9NHC5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEAFTRTLQNTFRSTRTTRTTTTTTTNSSTSSTTNSALPSRIPKQQNYVSDISSPLIQDEGDNKVLKLRFDVSQYAPEEIVVKTVDQKLLVHAKHEEKSDTKSVYREYNREFLLPKGVNPESIRSSLSKDGVLTVDAPLPALTAGETLIPIAHK
Protein: Lariat debranching enzyme (EC 3.1.4.-) (P24309)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded, thereby facilitating ribonucleotide turnover. It also participates in Ty1 retrovirus-like transposition via an RNA lariat intermediate in cDNA synthesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}. Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- CWF19-like protein DRN1
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- Ribonuclease 3
- Pre-mRNA-splicing factor 18
Sequence:
MTKLRIAVQGCCHGQLNQIYKEVSRIHAKTPIDLLIILGDFQSIRDGQDFKSIAIPPKYQRLGDFISYYNNEIEAPVPTIFIGGNHESMRHLMLLPHGGYVAKNIFYMGYSNVIWFKGIRIGSLSGIWKEWDFNKQRPDWNDLENNNWKANIRNLYHVRISDIAPLFMIKHRIDIMLSHDWPNGVVYHGDTKHLLKLKPFFEQDIKEGKLGSPVTWQLLRDLRPQWWLSAHLHVRFMASIKHNKRSHEPPNKSTSKTKKNNNEIDLDLSSDEDERSGIMNCQEENEYDSKYGETRFLALDKCLPRRRWLEILEIEPDTSHASWKDENHRMFWDPEFINNLVICQKNKNLLSNKPFNSVNWIELSQSNREEGRDIDWENYAIPAYTLDIQKDEVRQTKAFISKFMT
Protein: Protein FAM162A (E2-induced gene 5 protein homolog) (Growth and transformation-dependent protein) (HGTD-P) (Q9D6U8)
Organism: Mus musculus (Mouse)
Function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
Subcellular location: Mitochondrion membrane {ECO:0000250|UniProtKB:Q96A26}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MWSLGGLRLAAGHCLRLYERNASSSLRFTRNTDLKRINGFCTKPQESPKTPTQSYRHGVPLHKPTDFEKKILLWSGRFKKEEEIPETISFEMLDAAKNKLRVKVSYLMIALTVAGCIYMVIEGKKAAKRHESLTSLNLERKARLREEAAMKAKTD
Protein: Ureidoglycolate lyase (EC 4.3.2.3) (Ureidoglycolatase) (O13843)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting (By similarity).
Interaction partners:
- Probable allantoicase
- mRNA export factor elf1
- Elongation factor 3
- Urease
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL39
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein eS21
Sequence:
MEAKKIYAQALTDEAFAPFGSVVQQKDDVKMVSANGGTAKKYLKVSESIQNYEKSSSASTRKGVWNFFSTHPSVHPANDEHAAFQISVLERHPFTTQTFIPMCRSSDEQAYLIAVAPNAPDGMPDWNQTQAFVAKGAQGVTYSAGVWHAPMVTIGKETMLAAFNYENGVAEDDCQVQSTESPIEVFIKIST
Protein: AHNAK protein (Q9BVU3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEKEEETTRELLLPNWQGSGSHGLTIAQRDDGVFVQEVTQNSPAARTGVVKEGDQIVGATIYFDNLQSGEVTQLLNTMGHHTVGLKLHRKGDRSPEPGQTWTREVFSSCSSEVVLNTPQPSALECKDQNKQKEASSQAGAVSVSTPNAGL
Protein: Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase SAD-A) (Q69Z98)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion, BRSK2 phosphorylated at Thr-261 can promote insulin secretion. Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MTSTGKDGGGAQHAQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSHEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFINLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGEAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDQPSAQHLSDTTNCMEVMTGRLSKCGTPLSNFFDVIKQLFSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGGDTEYPMGKDMAKMGPPAARREQP