wanglab/gogpt-training-data huggingface dataset:
Protein: Checkpoint suppressor 1-like, isoform C (M9PDZ5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MSTDNPTQLLTTRDLSQLRGHLQSGTVAVPSTTTSVVAAAAATVAAAHGYRTIAPPQQPANNSSTTTSATAASASASAQPPVIPPVISTSNSNMPASASKYVFLQHNHNGGFTAYDGSAATTAAGSTGTVGATSGNIVLLAAAPLEASSGEALVNVRTTEDDGELRSLSWLSDTNLIKGIVTTTAGQAGKRAATVAIKSATGAAGTVGSGAPNGNLCIVSDLIEELPTNLSETSEQESTGGAASGSAPAASTVYSTTTVHKGASGTTTVVEYKASKANQQQQNSPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTYLPTPTRTTMVGHGYMPVVVSSASQPILSPAKQQLPQQIYVTSNGSSPAGGGTIYKAASQALSSPTTSSSSSSNTTTHHPHKKYLREKMHVQMDHSSHVASTVTVVSSPASSNNSSISSSNTGSVSGSGSSTAAVNGGNSPVPKTSSFSTVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESPAVVTTTTLISAGTLPPGYSFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYYATSTTSAGTTTTTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDSLKEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEKAPNMGKGSLWRVEPQQRQNLIQALNRSPFFPNSAVDKISPSLKSPSGGSAYDSLDGGGSGSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYLFPNLSKAFRNIREDTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANGSGGAGSGGVGSNANGASDGINFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGGPVITSSPSEDHTYSAGGNSNADSGSSTPLTNGNALASVAQAVAQGQNNQGGAGSDSNCASSDAAYDSSEENHNITPEEMADRQRHRDGVDALLSLSGSSIVECGSVATTHYHSNGSSGSSHGSPHKRASSHSLEEEHLQQHREQQLQQQQQQQQHHHQQFGSSQAVYTNGSGSKMALLSSAAANVALAQQQQQQIHQDMYSSTAGHNASMYLGGLNSHCLSGGGGVGVAAGMLPQHLSAATGASNKNKVKPLRGLRTKFKRKSAWMR
Protein: Dendritic cell-specific transmembrane protein-like domain-containing protein (Q17461)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Uncharacterized protein
- TRP homologous cation channel protein
- Sperm transmembrane protein 9
- Ig-like domain-containing protein
- Palmitoyltransferase spe-10
- Spermiogenesis protein SPE-29
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Sperm vesicle fusion protein fer-1
- CX domain-containing protein
- SPE-12
Sequence:
MGLIGLWNVKRRANRAVRKFQFVVNNIRREKSGQNRVLRYSERLKKWLSVLYPPWKKEKDDGIYDNLFEDGTRANSIVLLFRNILMIELFGIVMYFLLSFKYSQYPEFIGTSISTIIHVFLIFTLIFPKMMTYFMISIHVMLTTKIKNIILILLVTMAFEGPAMNVIGNIHQVASGVACVQIDVMSSRNDVEGNVMDKGAMLVSRFRALLQNVSGPMNKVKKMLLVLDEKMTKFVDIMRRHYRVIANLSNQCRNMLKTPYTKCLDIFDDAYFYCKGKARFFGSHGDACEMIQKTAKICHQAKGFSTEVCSLPSIIGKGVKGAAVPFYAAYFQAIEFAVKKIFYVHIEAAKWALKKVNPVIEEIKKAKNIRAEYQSSDDGKPNAADDTTANLRASIKKSLMGIVNVYIRIINIISFILRYCIMPGLLIWPFIYTLRFMYNYNYNDDFKNRFLTKEFTKIDQDCAFRGARKVMPLMANESKQYVSRGQWKMTEQERPKFRLDIFITIVSCVTPFFMCMLDYGIFTTLSTVHTLMNRTNIDTPAHYELKVAGNSSMSDVMNEFLDVFSPFTKSIRDRENRWRRCFNEPNPPNYTENMVMFLMFIAALFLCRLKAYFGRQTLVLADYFFPNRVRIRALSLYNKILQSRRNLLTEMLGNNKKDVVGGEDVIIRRTMQSRGFVCSDCVKCEKYDMKVSDQENVRVCVHCSAFYCINCFSVTLFCVKCEEEMQCINGIELYYEESNAIIDDSDISLSEREDDEPDKEPTEGTTTTAVTTVV
Protein: Zinc finger protein 800 (Q0VEE6)
Organism: Mus musculus (Mouse)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MPLRDKYCQTDHHHHGCCEPVYILEPGDPPLLQQPVQTSKSGIQQIIECFRSGTKQLKHILLKDVDTIFECKLCRSLFRGLPNLITHKKFYCPPSLQMDDNLPDVNDKQSQAISDLLEAIYPRVDKREYIIKLEPIETNQNAVFQYISRTDNPAEVTESSSTPEQTEVQIQETSSEQLKAVPDADTEVEEAIEPPSIETVVDEAAAPTEEQPQESQADLETSDSSDLGHQLICCLCRKEFNSRRGVRRHIRKVHKKKMEELKKYIETRKTPNQSSKGRSKSVLVSLSRSCPVCCKSFATKANVRRHFDEVHRGLRRDSITPDIATKPGQPLFLDSASPKKSFKTRKQKSSKAEYNLTACKCLLCKRKYSSQIMLKRHMQIVHKITLSGANSKREKGPNNTANSSEVKVELADSVESSPPSITHSPQNELKGTNHSNEKKNTPATQKNKVKQDSESPKSASPSAAGGQQKTRKPKLSAGFDFKQLYCKLCKRQFTSKQNLTKHIELHTDGNNIYVKFYKCPLCTYETRRKRDVIRHITVVHKKSSRYLGKITASLEIRAIKKPIDFVLNKVAKRGPSREEAKHNDSKQDGTSNSPSKKYEVADVGIEVKVTKNFSLHRCNKCGKAFAKKTYLEHHKKTHKANATNSPEGNKTKGRSTRSKALV
Protein: Ethylene-responsive transcription factor ERF107 (Q9FKG2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- ATP-dependent RNA helicase
Sequence:
METFEESSDLDVIQKHLFEDLMIPDGFIEDFVFDDTAFVSGLWSLEPFNPVPKLEPSSPVLDPDSYVQEILQMEAESSSSSSTTTSPEVETVSNRKKTKRFEETRHYRGVRRRPWGKFAAEIRDPAKKGSRIWLGTFESDIDAARAYDYAAFKLRGRKAVLNFPLDAGKYDAPVNSCRKRRRTDVPQPQGTTTSTSSSSSN
Protein: Cullin-4 (CUL-4) (Q17392)
Organism: Caenorhabditis elegans
Function: Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1.
Interaction partners:
- WD_REPEATS_REGION domain-containing protein
- RING-box protein 1
- DNA damage-binding protein 1
- DDB1- and CUL4-associated factor 11 homolog
- COP9 signalosome complex subunit 5
- DDB1- and CUL4-associated factor homolog 1
- Cullin-associated NEDD8-dissociated protein 1
- Ubiquitin-like protein NEDD8
- CDT1 Geminin-binding domain-containing protein
- CULT domain-containing protein
Sequence:
MTSGAPPTISTEKSRSKQLRKSSKRTASTVEGTEAKQMRGDTENRSDGEMDDVSTSSEIRHGNGFIENFRSQTGNSSRTTATNERIKKKLVIKNFKANANQNDVAMGDTNIDSTDGSVGRDWAVLSDNVFAILEDRKTVTTLEGLFSKVRSVCDKNQSKVLYDRLVAIVVQFAKSLKESLNAVEQVPLAEDNCEQYLEKFGQIWQAYPVKINLIRNIFLHLDRIALGATDTEILPLWECFMQIFQKTFFPNIFKEFKATKLFNALYMAMQKIMQRYPVDSPLRSLVDMLQTVHVSEEFAKFLISQLREHYNNERIDKVPKMNCNDYMEYCEDQINRYSQLVKVNFDEPSALKDVQATVTNCLIQQAIPEILTHDFDDLIDSDNISDIGRMFNLCRQCVGGEDEVRTQFSKYLKKRGEKLIATCPDEDLVSELLAFKKKVDFIMTGSFKSANDPVKMRQCLSDAFESFVNKQVDRSAELISKHFHTLLHSSNKNVSDDTTLDQMVDEAIVLFRYLRGKDVFEAYYKRGLAKRLFLERSASVDAEKMVLCKLKTECGSAFTYKLEGMFKDMDASENYGRLFNQYLEHMNKEKANFTARVITPEYWPTYDTYEINIPKEMRDTLTDYQDFYRVQHGNRNVKWHHGLASAVISASFRPGCKKELIATMYQTVILLLFNKCETWTVAEIVEHTKILEIEVVKNVLALLGGRDKPKVLQRVEGGGSEKKEGTVENLKNEKFVVNSKFTEKRCRVRIAQVNIKTAVEETKEVKEEVNSDRQYKIDAAVVRIMKARKQLNHQTLMTELLQQLRFPVSTADIKKRLESLIEREYISRDPEEASSYNYVA
Protein: FAD/NAD(P)-binding oxidoreductase family protein (F4JQE2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- QWRF motif protein
- AT4g30750/T10C21_100
- Uncharacterized protein AT4g30730
- 2-carboxy-1,4-naphthoquinone phytyltransferase, chloroplastic
- AUGMIN subunit 8
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Protein CHLOROPLAST IMPORT APPARATUS 2
Sequence:
MSLSQTNFLSSSLLSSSHDLRIPYSRAVLSYPRIQTHRILCAAKRTGKRRYPSERRKLRTEQKEAVAKVKNKLEGVWRLSKLGVPVGDDPGKDFLGISEGLLQAIAKVIEFPVASMLPEEAFSVIRKSFDARKILKEAKFVYTVDLDVKTLLELEPRAHDFIFRLEPKIGLIEHVPTEKSVSGDLISVVNDCKRINSETASGEYEPQIINGSGDPHHHGGGRSKPKIAVVGGGPSGLFAALVLAEFGADVTLIERGQAVEERGRDIGALVVRKILDMESNFCFGEGGAGTWSDGKLVTRIGKNSATVLAVLKTLVRFGAPDNILVNGKPHLGTDKLVPLLRNFRHYLQSAGVTIKFGTRVDDLLVEDSRVVGVRVSDSTNQLQTTSQNLKVDAVVLAVGHSARDTYEMLHSRNVELIPKDFAVGLRIEHPQELINSIQYSDLANEVLKGRGKVPVADYKVVQYVNDKTEDLSQSSSKRSCYSFCMCPGGQVVLTSTNPTELCINGMSFSRRSSKWANAALVVTVSAKDFDVLNLKGPLAGIEFQREFERRAAIMGGGDFTVPVQRVTDFLQNKLSETPLPPSSYRLGVKSANLHELFPAHITEALRESISMFEKELPGFISEEALLHGVETRTSSPVRIPRSNETYESTSLKGLYPVGEGAGYAGGIVSAAVDGMFSGFAVAKSFDLFDGTIESVIGKAQGAGLVKY
Protein: Bone morphogenetic protein 7 (Q9I8T6)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
DSSFIHRRLRGPERREMQREILSIFGLPHRSRPHLHGKHNSAPMFMLDLYNAMSVEEGGAGAAAEEGEGFSYPYKPIFSTQGPPLASLQDSNFLTEADMVMSFVNLVEHDREFHHQRCHYREFRFDLSRIPEGEAVTAAEFRIYKDYIRERFDNETFQISVYQVLQEHPGRDSDLFLLDSRTIWAAEEGWLVFDITATSNHWVVNPQHNLGLQLSVESIDGQSINPKLAGLIGRHGPQNKQPFTVAFFKATEVHLRSIRSTGGKQRSQNRSKTPKNQEAFRVSNIAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
Protein: Terminal uridylyltransferase 1 (TUTase 1) (EC 2.7.7.52) (3' terminal uridylyl transferase) (3' TUTase) (RNA editing 3' terminal uridylyltransferase 1) (RET1) (RNA editing TUTase 1) (Q8WQX5)
Organism: Trypanosoma brucei brucei
Function: Terminal uridylyltransferase which is involved in the post-transcriptional editing of mitochondrial RNA, a process involving the addition and deletion of uridine (U) nucleotides in the pre-RNA. Specifically, catalyzes the addition of Us to the 3'-hydroxyl group of guided RNA (gRNA), ribosomal RNA (rRNA) and some mRNAs. As part of the mitochondrial 3' processome (MPsome), catalyzes the primary 3' uridylation of gRNA precursors to facilitate their recognition and to induce their processive 3'-5' degradation by DSS1, and the secondary 3' uridylation of mature gRNAs. Involved in the 3' uridylylation of the long A/U tail of some edited and never-edited mRNAs. Promotes 3' uridylylation-mediated decay of some never-edited mRNAs. Does not mediate RNA-independent UTP polymerization.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19465686, ECO:0000269|PubMed:26833087, ECO:0000269|PubMed:27744351}.
Interaction partners:
Sequence:
MVSKYHRLLQQGLREEEEGVTERNMVAGGEQRHGHVDDDNAEGDADFYDQKDERRAKMWNPKHESANVSAGGKQNRSVRDCLPGSLPPVANTSTDAAVRFDRERKNAGHGVDISCVEGDGAQMGTYVSTGRSDAKAGGGSSAIGVTADDESDGNLDTDGSDASEGDEVESTTDADVYGEDDTTEGPRGGVRLYSCDACPHAVFTTHAALLAHAEEHHADLLPDHARLRRIAQKLNPVWNRALNARRNTITSWGKKIFHVAAQRDAGESKMQEAHRARAQLECVVRRWHDKARVFIFGSSVAMGVWDGTADIDFAVVDVDAMERGSWPPLEKNAVRSITELLRRVGFSFVNLEPISHARVPIIKHHASSPILTVARRDAEDVVARSIRFILNGPATREDRLLLEGSVRDAVGPTGVQQVWWNRTSDMMSATLESTTAAVRAAMCSPALASASLRTKVQPAHDECRPELYNIDFDLSFRAFGIRNSTLLRKYLLSHPCARPGAIVLKDWSKTSGVNNSVNGYFTSYAINIMWIYYLVQKGYVPYVDPLEIPESLVNYTDFDPRYTPMIDPEITNTEREELYKAAGDMLVGFFYFYSFEFDWGHNVISLNRPGITTKRMLGWHVEDVVPVASTSVSSGGGGSNVKRHPTRYELCIEDPYEENLNLGRHIGVTKSLRVRTELYRGLLSLLKEGETRSCVFAAADSSGTPAAGGKQSAALPARALFKLMALTTQAISESRRLPQSNSDNSGRIANGDNESLTEVGGGHRVEGAGVDPASCAGASLSSFGEPPIGVHEKTLESIFVEKAPMEFQLVRKVWNWHQLIHRLGYKIHRGHVMPRREVGVRCTARRDAEETTTELASGVDTTKSLRPGRGLTDTMLRDLSRGYMTLTPEWVAWSAPWVSQHLRGYSRLTTVRSAVADETPPALATVPSVVKPPTGEAVMGAMRTTRRNAAPARRVELLKLWLWRGISKVTPFKSPR
Protein: ACP53C14C (Q6GUU9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKSKQVFYIAFSLLLLGSLLPNDVESLRVDLNKLAECTESGLKVATTLIVRAIPCVKKLAKCADFRAIKTKDLDITALALLGYQYLQTVVNNQRCLLISLKEGYDAVSPHLDKLISGKCLPGLS
Protein: SD03187p (Q8T9F6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVDSHNVVTARQYTDVVIPCKPAMPDTEVLLETSNGESTWKISSKGQIQGNPKFFDSVRYHPRWGFTFRVIDCVSGYLYCKTLDYELIIDVTYPEKDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYVNGHIVPDIRIEELPDDYMEMSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMPTVDVADQAPEEIPMLHRSSTGSDGSPEQGRRFNQALKQQYVTPTPSPRHHVETKLNGEPSENYVNMKPPRKNIPGKTTTGGGGAAAGASTEAFSNPSYQPLSTVNEKEQRRY
Protein: Uncharacterized protein (Q580D4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRCSARIFCDDTLLRQWKKHLTEGQPLTKGDAFRLMRRTLNETQRAEQQQRLSFLASKGNSTTVWKALARHNITWRNSLTLMDAQLAAFSPSRREFVCSRLGPTSRLWMQLPHVIVGAWQTEDDMLAVFNRLLASETIVQFASIVLAAIRERPQLGGVLPVVSCVLLHCYELGGKQPDTALSCCRLLALVGAEKLPRSEREVLAFRYAMLYATQGQWSVALSVVNAAHEVRPSAKRLLWLHTSRMVQWIKAIECLHPVEPSFVASSIEYAPNWLCALRTYERWRSRDAAQALLIRKDCISAVGWEASLHFCSQNGVDSYGILRPILSMVPGDHPQRMQILTDATRATGESMYAGTLSRRAFKLAQRGEWAEAIGLLCGCRYYDVALPLAPYASRGAALPHELLAYEGALCRVNLPGGLQAPVSFEEQLAVALHGDWRQLKNVHDNARLKSLMLARSEPKLSPKSPILEESSEIQCFTFQSEELSRLVCLSASSKVQQYFVQVIPQELRKHHFGLRRRGGLKPVSPDRYAKFLSGNEIVTDGEGCNALCAIVVEHLRLTNKLSGEAFLREVSRCLASGKVQLTAGLRHEFSLAVLRATPHFGRLDATLSSRIALTTPLHYLTAHAVALESCMSALALTGQWERAIVIMQRTKPPYPESSAALAYVAPRHLALNVVKLLWRGNPQDRWTLVLQDLLHGDTRFATDELVISAFRTKFSNGRKDVQWRRRVLGACCALLQSSQSMHDVMQTAKLSTLCALDVDEHGLQRLLRVLSWEQALTAIGDLSENNEVIDEHWLLIACMKPHIPFDAVSKGVSLFPYSFLLNTVRVYYQAVEEKSLVTAVKAVYRYQMLVMKEYRADATYLRPLVTLLKGLLLHYDGERWSDTTVWPLVRRLFNHIVEGFGMTQLGREGRRGVPVALREDKPLHALLIIGLLYHHLSRVMQMPIPANITSHLLRSAAYGTNDYNAALYFFKSLKHPNIYERSLLVFALRDVDDAMTLLLRAGRFVHDRPEQALLWSDSRRGSDRWLLSIELLSQSPPPRGKLLNLCRGWTWAEALRVMELLRRIMGTSPEAKMYAELVRECHLGGAANVVISPIPTNGEGE
Protein: Helix-loop-helix DNA-binding domain containing protein, expressed (Q10ER2)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAVDWIWERRRREEEYNHQMSQDELQQPGQVQWTPAPEEKSEIAVQFFTAPYPCQNGQLDHGEHHALGGIGACSSVHWQPDRGTCYWPPPLSGDGGGGSGSGSSGTGEGSYIGERCYYVGEPDVPIGLNLLVGDNDGAGVVLRDAAPQAKRRTQAGHGGDLGRQKKKARVSDKRNQESMQSGSCSDNESNCSQVNRRKVDRVAGGGNGKVPARRRSATIAQSLYARRRRERINGRLRILQKLVPNGTKVDISTMLEEAVHYVKFLQLQIKVEVQIVCHDQMLSSDELWMYAPIVYNGMDLGIDLNISPPR
Protein: Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) (P00918)
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15990874}. Cell membrane {ECO:0000269|PubMed:15990874}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. {ECO:0000269|PubMed:15990874}.
Interaction partners:
- Sodium/hydrogen exchanger 1
- Band 3 anion transport protein
- Electrogenic sodium bicarbonate cotransporter 1
- V-type proton ATPase 116 kDa subunit a 3
- V-type proton ATPase subunit B, kidney isoform
- Carbonic anhydrase 1
- Cystathionine beta-synthase
- Cystathionine beta-synthase-like protein
- H
- 1,25-dihydroxyvitamin D
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Protein: Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2) (mTR2) (Q505F1)
Organism: Mus musculus (Mouse)
Function: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Subcellular location: Nucleus. Nucleus, PML body. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-210 phosphorylation, to PML bodies for subsequent sumoylation.
Interaction partners:
- Nuclear receptor-interacting protein 1
- SUMO-conjugating enzyme UBC9
- Nuclear receptor corepressor 1
- Small ubiquitin-related modifier 1
- Nuclear receptor subfamily 2 group C member 2
Sequence:
MATIEEIAHQIIDQQMGEIVTEQQTGQKIQIVTALDHSTQGKQFILANHEGSTPGKVFLTTPDAAGVNQLFFTSPDLSAPHLQLLTEKSPDQGPNKVFDLCVVCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCRGSKDCVINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSETARSAGLLDSGMFVNIHPSGIKTEPAMLMAPDKAESCQGDLSTLASVVTSLANLGKAKDLSHCGGDMPVVQSLRNGDTSFGAFHHDIQTNGDVSRAFDTLAKALTPGESSACQSPEEGMEGSPHLIAGEPSFVEKEGPLLSESHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHSSLQQDKMSPERRKSLMEHIFKLQEFCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLENMELIERFQEKAYVEFQDYITRTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRIDSVIPHILKMEPADYNSQIIGHSL
Protein: Dihydroxy-acid dehydratase, chloroplastic (AthDHAD) (DAD) (EC 4.2.1.9) (Q9LIR4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Ketol-acid reductoisomerase, chloroplastic
- 2-isopropylmalate synthase 2, chloroplastic
- Branched-chain-amino-acid aminotransferase 5, chloroplastic
- Branched-chain-amino-acid aminotransferase 2, chloroplastic
- Branched-chain-amino-acid aminotransferase 1, mitochondrial
- Putative branched-chain-amino-acid aminotransferase 7
- Branched-chain-amino-acid aminotransferase 3, chloroplastic
- 2-isopropylmalate synthase 1, chloroplastic
- Branched-chain-amino-acid aminotransferase 6
- Threonine dehydratase biosynthetic, chloroplastic
Sequence:
MQATIFSPRATLFPCKPLLPSHNVNSRRPSIISCSAQSVTADPSPPITDTNKLNKYSSRITEPKSQGGSQAILHGVGLSDDDLLKPQIGISSVWYEGNTCNMHLLKLSEAVKEGVENAGMVGFRFNTIGVSDAISMGTRGMCFSLQSRDLIADSIETVMSAQWYDGNISIPGCDKNMPGTIMAMGRLNRPGIMVYGGTIKPGHFQDKTYDIVSAFQSYGEFVSGSISDEQRKTVLHHSCPGAGACGGMYTANTMASAIEAMGMSLPYSSSIPAEDPLKLDECRLAGKYLLELLKMDLKPRDIITPKSLRNAMVSVMALGGSTNAVLHLIAIARSVGLELTLDDFQKVSDAVPFLADLKPSGKYVMEDIHKIGGTPAVLRYLLELGLMDGDCMTVTGQTLAQNLENVPSLTEGQEIIRPLSNPIKETGHIQILRGDLAPDGSVAKITGKEGLYFSGPALVFEGEESMLAAISADPMSFKGTVVVIRGEGPKGGPGMPEMLTPTSAIMGAGLGKECALLTDGRFSGGSHGFVVGHICPEAQEGGPIGLIKNGDIITIDIGKKRIDTQVSPEEMNDRRKKWTAPAYKVNRGVLYKYIKNVQSASDGCVTDE
Protein: Homeobox protein MSX-1 (Homeobox protein Hox-7) (Hox-7.1) (Msh homeobox 1-like protein) (P13297)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis.
Subcellular location: Nucleus {ECO:0000269|PubMed:16600910, ECO:0000269|PubMed:23371388}. Note=Interaction with PIAS1 is required for localization to the nuclear periphery (PubMed:16600910). {ECO:0000269|PubMed:16600910}.
Interaction partners:
- Homeobox protein MSX-2
- Paired box protein Pax-9
- Histone H1.5
- Homeobox protein MSX-3
- Cysteine/serine-rich nuclear protein 1
- Bone morphogenetic protein 4
- Protein odd-skipped-related 2
- Lymphoid enhancer-binding factor 1
- LIM/homeobox protein Lhx8
- Zinc finger protein SNAI1
Sequence:
MAPAAAMTSLPLGVKVEDSAFAKPAGGGVGQAPGAAAATATAMGTDEEGAKPKVPASLLPFSVEALMADHRKPGAKESVLVASEGAQAAGGSVQHLGTRPGSLGAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKLDRTPWMQSPRFSPPPARRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYSASGPFQRAALPVAPVGLYTAHVGYSMYHLT
Protein: Histone H4 (Q76NW2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H2B.v3
- Probable histone-binding protein rbbD
- Histone H3.3 type c
- Histone H3.3 type a
- Histone H3.3 type b
- Histone chaperone asf1
- PWWP domain-containing protein
- Histone H2A.z
- Histone acetyltransferase type B catalytic subunit DDB_G0274269
- Protein arginine N-methyltransferase 1
Sequence:
MSSAQSRGGKTGGKVGGKVGAKRHKKTQKEHINGITKPAIRRLARRGGVKRISFPIYEETRNVLRTFLTNVIRDSVAYTEHAGRRTVTAMDVVYALKRQGRTLYGFNS
Protein: Probable cyclic di-GMP phosphodiesterase PdeD (EC 3.1.4.52) (P76261)
Organism: Escherichia coli (strain K12)
Function: Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity). May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); overexpression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable diguanylate cyclase DgcC
- Diguanylate cyclase DgcM
- Diguanylate cyclase DgcP
- Cellulose synthase catalytic subunit
- Probable diguanylate cyclase DgcE
- Diguanylate cyclase DgcN
- Diguanylate cyclase DosC
- Probable diguanylate cyclase DgcT
- Probable diguanylate cyclase DgcQ
- Probable diguanylate cyclase CdgI
Sequence:
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSNAGVMEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGPGATALAWHYLPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR
Protein: Thymidylate synthase (EC 2.1.1.45) (Q6P045)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Thymidine kinase.
- Dihydrofolate reductase.
- Zgc:153031.
- Serine hydroxymethyltransferase
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial 2, methenyltetrahydrofolate cyclohydrolase)
- Thymidylate kinase
- Deoxycytidylate deaminase
- glycine hydroxymethyltransferase
- Methylenetetrahydrofolate dehydrogenase
- Folylpolyglutamate synthase
Sequence:
MPDTAVEVTNGHCVNGESKKETNGGKKEFSLFCDERGYLSLVEFILQNGAKKGDRTGTGVISVFGTQARYSLRDQFPLLTTKRVFWKGILEELLWFIKGSTNAKDLSEKGVRIWDANGSREFLDKNGFTDREEGDLGPVYGFQWRHFGAEYKDMHTDYSGEGVDQLQKVIDTIKSNPEDRRIIMCAWNPKDLPLMALPPCHALCQFYVSNGELSCQLYQRSGDIGLGVPFNIASYALLTYMIAHITGLKPGDFVHTLGDAHIYTNHIEPLKEQIQREPRPFPKLRIKRKVEQINDFCAEDFEIYDYNPHPTIKMQMAV