wanglab/gogpt-training-data huggingface dataset:
Protein: Peptidoglycan transglycosylase gp16 (EC 4.2.2.n1) (Internal core protein gp16) (P03726)
Organism: Escherichia phage T7 (Bacteriophage T7)
Function: Component of the cylindrical core that assembles on the inner surface of the capsid during capsid formation and plays a role in viral DNA ejection into the host cell. The inner core is composed of stacked rings of gp14, gp15 and gp16 proteins. Following binding to the host cell surface, the internal core is diassembled and gp16 is ejected along with gp14 and gp15 into the infected cell. Gp16 probably inserts in the host inner membrane and remains associated with gp15. The gp15-gp16 complex binds to both the viral DNA and the host inner membrane, probably escorting the leading end of the genome through the periplasm and controlling the extend of DNA translocated into the host cell. Functions as an exolysin that catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycans allowing the local digestion of the bacterial peptidoglycan wall.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04121, ECO:0000269|PubMed:23884409}. Host cell inner membrane {ECO:0000255|HAMAP-Rule:MF_04121, ECO:0000269|PubMed:23306440}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_04121}. Note=The gp15-gp16 complex spans the periplasm and the cytoplasmic membrane. {ECO:0000255|HAMAP-Rule:MF_04121, ECO:0000269|PubMed:23306440}.
Interaction partners:
Sequence:
MDKYDKNVPSDYDGLFQKAADANGVSYDLLRKVAWTESRFVPTAKSKTGPLGMMQFTKATAKALGLRVTDGPDDDRLNPELAINAAAKQLAGLVGKFDGDELKAALAYNQGEGRLGNPQLEAYSKGDFASISEEGRNYMRNLLDVAKSPMAGQLETFGGITPKGKGIPAEVGLAGIGHKQKVTQELPESTSFDVKGIEQEATAKPFAKDFWETHGETLDEYNSRSTFFGFKNAAEAELSNSVAGMAFRAGRLDNGFDVFKDTITPTRWNSHIWTPEELEKIRTEVKNPAYINVVTGGSPENLDDLIKLANENFENDSRAAEAGLGAKLSAGIIGAGVDPLSYVPMVGVTGKGFKLINKALVVGAESAALNVASEGLRTSVAGGDADYAGAALGGFVFGAGMSAISDAVAAGLKRSKPEAEFDNEFIGPMMRLEARETARNANSADLSRMNTENMKFEGEHNGVPYEDLPTERGAVVLHDGSVLSASNPINPKTLKEFSEVDPEKAARGIKLAGFTEIGLKTLGSDDADIRRVAIDLVRSPTGMQSGASGKFGATASDIHERLHGTDQRTYNDLYKAMSDAMKDPEFSTGGAKMSREETRYTIYRRAALAIERPELQKALTPSERIVMDIIKRHFDTKRELMENPAIFGNTKAVSIFPESRHKGTYVPHVYDRHAKALMIQRYGAEGLQEGIARSWMNSYVSRPEVKARVDEMLKELHGVKEVTPEMVEKYAMDKAYGISHSDQFTNSSIIEENIEGLVGIENNSFLEARNLFDSDLSITMPDGQQFSVNDLRDFDMFRIMPAYDRRVNGDIAIMGSTGKTTKELKDEILALKAKAEGDGKKTGEVHALMDTVKILTGRARRNQDTVWETSLRAINDLGFFAKNAYMGAQNITEIAGMIVTGNVRALGHGIPILRDTLYKSKPVSAKELKELHASLFGKEVDQLIRPKRADIVQRLREATDTGPAVANIVGTLKYSTQELAARSPWTKLLNGTTNYLLDAARQGMLGDVISATLTGKTTRWEKEGFLRGASVTPEQMAGIKSLIKEHMVRGEDGKFTVKDKQAFSMDPRAMDLWRLADKVADEAMLRPHKVSLQDSHAFGALGKMVMQFKSFTIKSLNSKFLRTFYDGYKNNRAIDAALSIITSMGLAGGFYAMAAHVKAYALPKEKRKEYLERALDPTMIAHAALSRSSQLGAPLAMVDLVGGVLGFESSKMARSTILPKDTVKERDPNKPYTSREVMGAMGSNLLEQMPSAGFVANVGATLMNAAGVVNSPNKATEQDFMTGLMNSTKELVPNDPLTQQLVLKIYEANGVNLRERRK
Protein: Keratocan (KTN) (Keratan sulfate proteoglycan keratocan) (O35367)
Organism: Mus musculus (Mouse)
Function: May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
- Growth-regulated alpha protein
- Lumican
- Mimecan
- Aggrecan core protein
- Keratin, type I cytoskeletal 12
- Aldehyde dehydrogenase, dimeric NADP-preferring
- Leucine-rich repeat protein 1
Sequence:
MATPNCLILWVLLIADTVWTQSVRQAYEIQDPEDWDVHDDFYCPRECFCPPSFPTALYCENRGLTEIPPIPSRIWYLYLENNLIESIPEKPFENATQLRWINLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQHNKLLDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDAGLPSRGFDVSSILDLQLSYNQLTNFPRINANLQHLHLDHNKIKNVNMSVICPTTLRAEQDAFIHGPQLSYLRLDGNEIKPPIPIDLVACFKLLQAFII
Protein: Cbp/p300-interacting transactivator 4b (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b) (Cited3 protein) (A8E5L7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Zinc finger protein 142
- Mediator of RNA polymerase II transcription subunit 1
Sequence:
MAEHMMMPMNHGQGNGGLHGYRMGMNGGLQAGPQQHIPQSGLRAMPNGQMMHYGAGPQGNMEAAMRQRANMVGPMNGQMGHHRMQSTNMMFNNQGQPQQHHVQQHQQQHQQHHHMQQQQPQPPPPQQQQQQQQQQQYMTGGLTSQQLMASMHLQKLNTQYHGHPLGHMNGNHMGNGAQFRMGQAQLSNMQHMPGPALSLNGMDADLIDEEVLTSLVMELGLDRVQELPELFLGQNEFDFISDFVSKQQPSTVSC
Protein: Guanylate cyclase (EC 4.6.1.2) (Q8IQK2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MFAHPCPAPAGNYHSGLLHPLLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLPRNSLTRSSSLESPKKLRFAAGSLLEHHRYHSDEALLEVDSYTGLRRSSGGSTQSRYEETTLSLTLSCQSIEIVGGQHNKRRPSSYPTANTPLLMNHVEV
Protein: Chloromuconate cycloisomerase (P94138)
Organism: Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator (strain JMP 134))
Interaction partners:
Sequence:
MLTEKAIADSPNGGDADRKAAQIEAIETVIVDLPLRRIQQFARLGAKHQSSVLIRLHTKGGIVGIGESITPCGPWWSGDSVEAIQATINHYLAPLVVGEPALDASRIMAKLHGRVAGNAFAKAGIEMALLDAVGKIVDAPIHVLLGGRFRDRLSVAWPLATGDVNQEVDEAFRMLEAGKAGAFKLKMGALPLAQDLRRALAIAKELEGKASLRVDPNEAWDEPTTMRALAPLEAAGVEIIEQPVARWNLDAMARIHRQARSMLLIDEGVQSLHDASEVVKRAAAGLVSLKIMKTGGMRPARAMADIANAGGMHVYMGTFLETSIGTAANMQLAASIESLPTGAKSSGPC
Protein: Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) (Q13470)
Organism: Homo sapiens (Human)
Function: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10873601}. Membrane {ECO:0000269|PubMed:10873601}; Peripheral membrane protein {ECO:0000269|PubMed:10873601}.
Interaction partners:
Sequence:
MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDSTIWKGQNGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLARP
Protein: Ependymin (B9ENP4)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MRTFVLLMCLAVGCLAQVPHTCRSPPLLTGALSVANEKFYANAKYTYDAMLKRIRFKEIGSYENKTFGVDALLLFREGVMYTINHRNKTCKKERLKREDFHPMEIPADAALLGQVILGSSSGPGQGLLVNTWYGEVATPSGEDKWMSTFAEFGCIPVSSTYYTDKTGWILTTFFNIVVGITDPQEFFPPKFCQDAKLDETAEAANFYSIFKNLTKYS
Protein: Low affinity inorganic phosphate transporter 1 (PhPT1) (PhPht1;1) (Arbuscular mycorrhiza-induced phosphate transporter PT1) (AM-induced phosphate transporter PT1) (H(+)/Pi cotransporter PT1) (A7KTC5)
Organism: Petunia hybrida (Petunia)
Function: Low-affinity transporter for external inorganic phosphate (Pi) (By similarity). Involved in phosphorus (P) remobilization from dying to developing tissues during corolla senescence in an ethylene-dependent manner.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8GSG4}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAKDLQVLTALDVAKTQLYHFTAIVIAGMGFFTDAYDLFCISLVTKLLGRIYYHHEGALKPGSLPPNVAAAVNGVAFCGTLAGQLFFGWLGDKLGRKKVYGMTLMLMVICSIASGLSFGHTPKSVMATLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGFGILAGGMVAIIVSAAFKNQFPAPAYKDGALASTISQADFVWRIIVMFGAIPTALTYYWRMKMPETARYTALVAKNLKQATNDMSKVLQVEIEPEQEKVEEISQGNDFGLFTKQFLRRHGLHLLGTASTWFLLDIAFYSQNLFQKDIFSAIGWIPPAETMNALEEVYRIARAQTLIALCSTVPGYWFTVAFIDKIGRFAIQLMGFFFMTVFMFALAIPYTHWTHKDNRIGFVIMYSLTFFFANFGPNATTFVVPAEIFPARLRSTCHGISAAAGKAGAMVGAFGFLYAAQSTDPKKTDAGYPAGIGVRNSLIVLGCVNFLGMLFTLLVPESKGKSLEEMSRENEGEDENGTEMRASGRTVPV
Protein: Haloalkane dehalogenase 1 (EC 3.8.1.5) (P9WMS3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
Interaction partners:
- Haloalkane dehalogenase 3
- Haloalkane dehalogenase 2
- Probable zinc-type alcohol dehydrogenase
- Alcohol dehydrogenase B
- Probable alcohol dehydrogenase adh
- Probable alcohol dehydrogenase AdhA
- tRNA-specific adenosine deaminase
- Uncharacterized protein Rv2297
Sequence:
MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPGDGPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSDKPTRIEDYTYLRHVEWVTSWFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARLVVANGFLPAAQGRTPLPFYVWRAFARYSPVLPAGRLVNFGTVHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPTSPDDPAVPANRAAWEALGRWDKPFLAIFGYRDPILGQADGPLIKHIPGAAGQPHARIKASHFIQEDSGTELAERMLSWQQAT
Protein: Histone H1.4 (H1d) (P15865)
Organism: Rattus norvegicus (Rat)
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Subcellular location: Nucleus. Chromosome. Note=Mainly localizes in euchromatin. {ECO:0000250}.
Interaction partners:
- Histone H3.1
Sequence:
MSETAPAAPAAPAPAEKTPIKKKARKAAGGAKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGAAKKPKKATGTATPKKSTKKTPKKAKKPAAAAGAKKAKSPKKAKATKAKKAPKSPAKARAVKPKAAKPKTSKPKAAKPKKTAAKKK
Protein: Active regulator of SIRT1 (40S ribosomal protein S19-binding protein 1) (RPS19-binding protein 1) (S19BP) (Q8C6B9)
Organism: Mus musculus (Mouse)
Function: Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16289379}.
Interaction partners:
- NAD-dependent protein deacetylase sirtuin-1
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein uS12
Sequence:
MSAALVRRGLELLAASEAPRAVPGQVQASGTPAKRTRRARAKASQALKLRNSAKGKAPKSALAEYQKRQCRDHLKANLKFMTSMRSTVPESVTQQILQQNQGRKACDRLVAKTKNKKKKKKKAEGTVFTEEDFQKFQREYFGS
Protein: Beta catenin (O42486)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTTQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVLSAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGGTAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRPDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL
Protein: Cartilage-associated protein (Dualin) (Q90830)
Organism: Gallus gallus (Chicken)
Function: Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase B
- Prolyl 3-hydroxylase 1
- Serpin H1
- Peptidylprolyl isomerase.
- Transmembrane protein 38B.
- Protein disulfide-isomerase
- Collagen alpha-1
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2.
- Membrane-bound transcription factor site-2 protease
- Collagen alpha-1
Sequence:
MWRTLLAALLATAGAQYERYSFRSFPRDELMPLESAYRYGLDQYSTENWPESVSYLEVSMRLYRLLRDTEAFCHHNCSSAGPLTAPPPADGELAELRLLAGVLRRAQCLRRCKQGLPAFRQAQPGRELLEEFQRREPYKYLQFAYFKANNLPKAIAAAHTFLLKHPDDEMMQRNMAYYKSIPDAEEHIKDLETKPYENLFVRAVRAYNGDNWRTSISDMELALPDFFKTYDDCIAACEGSREIKDFKDFYLSIADHYIEVLACKVQFDITT
Protein: Cdc42-interacting protein 4, isoform A (FI02049p) (Q9VZD7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLALLASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIFNIFGSNKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEITLYA
Protein: Zinc finger protein 157 (D3Z0U7)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGLVSFEDVAVDFTWQEWQELDAAQRTLYRDVMLENYSSLVSLGHCVTKPELILRLEHGFQPWSIGDTSVWRLPGVLEVYTPNESCLENAESRMWPVGSINRNLSNKEMIEVGRNEGSTGTSPRYKTL
Protein: Septum-promoting GTP-binding protein 1 (GTPase spg1) (Sid3 protein) (P87027)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTP-binding protein essential for the induction of septum formation at G2 and pre-START stages of mitosis. Acts via the cdc7 protein kinase pathway.
Interaction partners:
- Cell division control protein 16
- Cell division control protein 7
- Septation initiation network scaffold protein cdc11
- Tyrosine-protein phosphatase CDC14 homolog
- Serine/threonine-protein kinase plo1
- Serine/threonine-protein kinase sid2
- Protein byr4
- Protein phosphatase PP2A regulatory subunit B
- Serine/threonine-protein kinase ppk15
- Septation initiation protein sid4
Sequence:
MADARKNNVTIKVGMIGDSSIGKTSLMVTYVQGSFDEESTQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPMVCNDAVAILFMFDLSRKSTLNSIKEWYRQARGFNKTAVPILIGTKYDHFMTFPREDQEEITKQARRYAKAMKASLVFCSTSHSINVQKIFKIVLAKVFDLKCTIPEIKNVGDPILEYIDR
Protein: Cytochrome P450 2S1 (EC 1.14.14.-) (CYPIIS1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Thromboxane-A synthase) (EC 5.3.99.5) (Q96SQ9)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11181079}; Peripheral membrane protein {ECO:0000269|PubMed:11181079}. Microsome membrane {ECO:0000269|PubMed:11181079}; Peripheral membrane protein {ECO:0000269|PubMed:11181079}.
Interaction partners:
- Cytochrome P450 3A4)
- Cytochrome P450 26A1
- Cytochrome P450 3A5
- Cytochrome P450 4A22
- Cytochrome P450 4A11
- Cytochrome P450 3A7
- Cytochrome P450 26B1
- Cytochrome P450 1A1
- Cytochrome P450 1A2
- Cytochrome P450 26C1
Sequence:
MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTDLHSTTQTR
Protein: Coronin-1B (Coronin-2) (O89046)
Organism: Rattus norvegicus (Rat)
Function: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BR76}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q9BR76}. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers. {ECO:0000250|UniProtKB:Q9BR76}.
Interaction partners:
- Coronin
- Src substrate cortactin
- Hematopoietic lineage cell-specific protein
Sequence:
MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFMVLPLNKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIITWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTAGFSRMSERQLALWDPENFEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTAGPDAALEAEDWVSGQDADPILISLREAYVPSKQRDLKVSRRNVLSDSKPAGYSRSGVSTATAITDIPSGNLAGSGEAGKLEEVMHGLRALRVLVKEQGERISRLEEHLGRMENGDT
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (Q91912)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
Sequence:
MSSILPFTPPVVKRLLGWKKSASGTTGAGGDEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPSTLSPVNHNLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
Protein: Glutamine amidotransferase-like class 1 domain-containing protein 1 (Ferry endosomal RAB5 effector complex subunit 5) (Fy-5) (Parkinson disease 7 domain-containing protein 1) (Q8NB37)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}. Early endosome {ECO:0000305|PubMed:37267905}.
Interaction partners:
- Protein phosphatase 1 regulatory subunit 21
- Quinone oxidoreductase-like protein 1
Sequence:
MASERLPNRPACLLVASGAAEGVSAQSFLHCFTMASTAFNLQVATPGGKAMEFVDVTESNARWVQDFRLKAYASPAKLESIDGARYHALLIPSCPGALTDLASSGSLARILQHFHSESKPICAVGHGVAALCCATNEDRSWVFDSYSLTGPSVCELVRAPGFARLPLVVEDFVKDSGACFSASEPDAVHVVLDRHLVTGQNASSTVPAVQNLLFLCGSRK
Protein: Transcription factor TCP17 (Q9LEZ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164). Participates in ovule develpment.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor TCP14
- Transcription factor TCP19
- Transcription factor TCP21
- Transcription factor TCP15
- Protein SPEAR3
- Transcription factor TCP20
- Cryptochrome-1
- Transcription factor TCP7
- Transcription factor TCP16
- Transcription factor TCP9
Sequence:
MGIKKEDQKSSLSLLTQRWNNPRIVRVSRAFGGKDRHSKVCTVRGLRDRRIRLSVMTAIQVYDLQERLGLSQPSKVIDWLLEVAKNDVDLLPPLQFPPGFHQLNPNLTGLGESFPGVFDLGRTQREALDLEKRKWVNLDHVFDHIDHHNHFSNSIQSNKLYFPTITSSSSSYHYNLGHLQQSLLDQSGNVTVAFSNNYNNNNLNPPAAETMSSLFPTRYPSFLGGGQLQLFSSTSSQPDHIE
Protein: Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) (P68402)
Organism: Homo sapiens (Human)
Function: Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Platelet-activating factor acetylhydrolase IB subunit beta
- Platelet-activating factor acetylhydrolase IB subunit alpha1
- Platelet-activating factor acetylhydrolase 2, cytoplasmic
- Platelet-activating factor acetylhydrolase
- Lysophosphatidylcholine acyltransferase 1
- Lysophosphatidylcholine acyltransferase 2
- Lysophospholipid acyltransferase LPCAT4
- Cholinephosphotransferase 1
- Choline/ethanolaminephosphotransferase 1
- Nuclear distribution protein nudE-like 1
Sequence:
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
Protein: Peroxisomal ATPase PEX1 (Peroxin-1) (A0A8I6ADS4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MWSSDRLAGAGSGGAVVTVAFTNARDCFLHLPRHLVAQLHLLQNQAIEVTGDHQPTYLSWVEGRHFNDQSENVAEINRQVGQKLGLSSGDQVFLRPCSHVVSCQQVEVEPLSADDWEILELHAISLEEHLLDQIRIVFPKAIVPIWVDQQTYIFIQIVALMPTAPYGRLETNTKLLIQPKTRQAKESTFPKEGDARGQAHNYGREQKGTVKELQTKQLHKNTEAVPVSNGRNPEVPGDSVKPRWWAVLGSMFSFGPDNKQESAWGSLELGAFKNMQSQTVPLDSIFRVCQVQPPSVHNTPANSVFHKHCTVHVFPWDQEYFDVEPSFTVVYGKLVKLHSPKQQQDKSKQGVLLPEKEKQLSQSPGHKRIGSDGSEEAAETCVLKVVWNGLEELKNATEFTKSLEPLHHGKVWPRDVSEEEVKAVFSSWLQESATTMFPLIISKQECIKLEIKDGLKEFSLSIVHSQEKEKEQGRTVFVLSPILLQKISVQVLLEPMIGEHSEEIDILLPSLTLSSLGGVSSLSVSAMEHITHSLLGRPLSRQLMALVAGLRNGALLITGGKGSGKSTLAKAICKEAHDALDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSTPEHEHSPEAVQSQRLAHALNNMIKEFVSMGSLVALIATSQLQHSLHPSLVSAQGVHTFQCIQHIQPPDQEQRCEILHSVVKNKLGCDISKSPDLDLKCIAKETEAFVARDFTVLVDRAIHSSLSRQQNPTREGLTLTTADFQKALRGFLPASLRNVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESGMNFISIQGPELLSKYIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSLPLADDVDLQHVASVTESFTGADLKALLYNAQLEALQGRLLPGGLHDGGSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGNGASCDLSSHCLSAPSSMTQDLPATPGKDPLFTQHPVFRTPSQEGSQDLTQEQRDQLRADISIIKGRYQSQSGEDESLNQPGPIKTSFAISQAHLMTALAHTRPSINEDEGKEFAELYENFQNPKKRKNQSGTVFRTGQKVTLA