wanglab/gogpt-training-data huggingface dataset:
Protein: Protein transport protein sft2 (Q9P6K1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. Can be replaced by got1 (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Protein transport protein got1
- AP-3 complex subunit sigma
- Intermembrane lipid transfer protein vps1302
- Integral membrane protein sed5
Sequence:
MEGSFQSRLQSIIQRTGETTAESTNSWYNRLRTSMPWSNDYTEIPTNASGGNSYFQSSEFSLSRWERYMLFGICLLGSLACYAIACFMFPVLVLKPRKFVLLWTMGSLLAVLGFAIVQGFVAHFRQLTTMERLPITLSYFVTLLATIIATIKIKSTILSIVFGVLHILSFVAYLIAFFPFGTRTVSLGTRMASRSLSNWLP
Protein: Holocytochrome c-type synthase (EC 4.4.1.17) (Cytochrome c-type heme lyase) (CCHL) (P53702)
Organism: Mus musculus (Mouse)
Function: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P53701}. Membrane {ECO:0000250|UniProtKB:P53701}; Lipid-anchor {ECO:0000250|UniProtKB:P53701}.
Interaction partners:
- Protoheme IX farnesyltransferase, mitochondrial
- Ferrochelatase, mitochondrial
- Heme oxygenase 2
- Heme oxygenase 1
- Heme A synthase COX15
- Cytochrome c1, heme protein, mitochondrial
- Rho GTPase-activating protein 6
Sequence:
MGASASSPATAVNASNASDGQPASPPSGCPMHKGQRKGCPVTAATSDLTSESKAHTVPAHQDRAYDYVECPVTGARAKDKESLDPSNLMPPPNQTPSPDQPFTLSTSREESSIPRADSEKKWVYPSEQMFWNAMLRKGWKWKDDDISQKDMYNIIRIHNQNNEQAWKEILKWEALHAHECPCGPSLVRFGGKAREYSPRARIRSWMGYELPFDRHDWIINRCGTEVRYVIDYYDGGEVNKEYQFTILDVRPAFDSFSAVWDRMKVAWWRWTS
Protein: Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) (Q9BTX1)
Organism: Homo sapiens (Human)
Function: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.
Interaction partners:
- Nucleoporin NUP35
- Nuclear pore complex protein Nup93
- Aladin
- Nuclear pore complex protein Nup205
- Nuclear pore complex protein Nup155
- Nuclear pore membrane glycoprotein 210
- Nucleoporin SEH1
- Nuclear pore glycoprotein p62
- Nucleoporin NUP188
- Nuclear pore complex protein Nup85
Sequence:
MATAVSRPCAGRSRDILWRVLGWRIVASIVWSVLFLPICTTVFIIFSRIDLFHPIQWLSDSFSDLYSSYVIFYFLLLSVVIIIISIFNVEFYAVVPSIPCSRLALIGKIIHPQQLMHSFIHAAMGMVMAWCAAVITQGQYSFLVVPCTGTNSFGSPAAQTCLNEYHLFFLLTGAFMGYSYSLLYFVNNMNYLPFPIIQQYKFLRFRRSLLLLVKHSCVESLFLVRNFCILYYFLGYIPKAWISTAMNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDLMLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSVPPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEGKTMRQPSVIYSWIQNKREQIKNFLSKRVLIMYFFSKHPEASIQAVFSDAQMHIWALEGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQEAVDKYFKLPHASSKPPRISGSLVDTSYKTLRFAFRASLKTAIYRITTTFGEHLNAVQASAEHQKRLQQFLEFKE
Protein: Chlorophyll a-b binding protein (LHCII type I CAB) (LHCP) (Q9T2L0)
Organism: Spinacia oleracea (Spinach)
Function: The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:1894641}; Multi-pass membrane protein {ECO:0000269|PubMed:1894641}.
Interaction partners:
Sequence:
RKTAGKPKN
Protein: Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (Outer mitochondrial membrane protein porin 2) (P68002)
Organism: Bos taurus (Bovine)
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity). Binding of ceramide promotes the Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P45880}. Membrane {ECO:0000250|UniProtKB:P45880}. Note=May localize to non-mitochondrial membranes. {ECO:0000250|UniProtKB:P45880}.
Interaction partners:
- Non-selective voltage-gated ion channel VDAC1
- Cytochrome c
- Non-selective voltage-gated ion channel VDAC3
- ADP/ATP translocase 2
- ADP/ATP translocase 1
- Cytochrome c 2
- ADP/ATP translocase 3
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Translocator protein
- ADP/ATP translocase 4
Sequence:
MATYGQNCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKLGLALELEA
Protein: ATP citrate synthase (EC 2.3.3.8) (Q8KDG1)
Organism: Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Citrate lyase, subunit2
- Succinate--CoA ligase subunit alpha
- Citrate synthase
- Aconitate hydratase B
- Pyruvate flavodoxin/ferrodoxin oxidoreductase
- Malate dehydrogenase
- Oxaloacetate decarboxylase, alpha subunit
- Alpha oxoglutarate ferredoxin oxidoreductase, alpha subunit
- Glutamate synthase, small subunit, putative
- Biotin carboxylase
Sequence:
MAKILEGPAMKLFNKWGIPVPNYVVIMDPKRLAQLGEANKWLRESKLVVKAHEAIGGRFKLGLVKIGLNLDEAIQASREMLGAKVGTAEVRQVIVAEMLDHDAEFYVSIIGNRDGAELLISKYGGVDIEDNWDSVRRIQIPLDEHPTIEQLTALAKEAGFEGEIAERVGKICSRLVLCFDNEDAQSIEINPLVIRKSDMRFAALDAVMNVDWDARFRHADWDFKPVSEIGRPFTEAEQQIMDIDSRIKGSVKFVEVPGGEIALLTAGGGASVFYADAVVARGGTIANYAEYSGDPPDWAVEALTETICRLPNIKHIIVGGAIANFTDVKATFSGIINGLRESKSKGYLEGVKIWVRRGGPNEAQGLAAIRKLQEEGFDIHVYDRSMPMTDIVDLALKS
Protein: Lissencephaly-1 homolog B (Platelet-activating factor acetylhydrolase IB subunit alpha b) (Q803D2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in the PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration (By similarity). Involved in the positioning of nuclei in photoreceptor cells.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03141}.
Interaction partners:
- Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit.
- Platelet-activating factor acetylhydrolase IB subunit alpha2
- Platelet-activating factor acetylhydrolase
- Lissencephaly-1 homolog A
- Uncharacterized protein.
- Cholinephosphotransferase 1
- Lysophosphatidylcholine acyltransferase 1
- Lysophosphatidylcholine acyltransferase 2
- Lysophosphatidylcholine acyltransferase 4
- Choline/ethanolaminephosphotransferase 1
Sequence:
MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDVNDELDKKFAGLLEKKWTSVIRLQKKVMELESKLNEAKEEITLGGPVGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESAHPTISEATGSENKKSGKPGPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVWECR
Protein: FMRF-Like Peptide (FMRFamide-like peptide 10) (G5EF22)
Organism: Caenorhabditis elegans
Interaction partners:
- FMRF-Like Peptide
- G protein-coupled receptor EGL-6 isoform b
- FMRF-Like Peptide
- FMRF-Like Peptide
- FMRF-Like Peptide
- FMRFamide-like neuropeptides 6
- FMRFamide-like neuropeptides 11
- FMRFamide-like neuropeptides 9
- FMRFamide-like neuropeptide 21
Sequence:
MQLSIVFVFFVLCLAAVFAVPISDASRARRQVASEKRQPKARSGYIRFGKRRVDPNAELLYLDQLLI
Protein: Pro-secreted protein ORF2 (Protein ORF2) (pORF2) [Cleaved into: Secreted protein ORF2 (ORF2s)] (Q9IVZ8)
Organism: Hepatitis E virus genotype 4 (isolate Human/China/T1) (HEV-4) (Hepatitis E virus genotype 4 (isolate Human/China/Ct1))
Function: Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.
Subcellular location: [Isoform Secreted protein ORF2]: Secreted {ECO:0000250|UniProtKB:Q81871}. Note=Cotranslationally translocated into the ER. {ECO:0000250|UniProtKB:Q68985}.; SUBCELLULAR LOCATION: [Isoform Capsid protein]: Virion {ECO:0000250|UniProtKB:Q81871}. Host cytoplasm {ECO:0000250|UniProtKB:Q81871}. Host endoplasmic reticulum {ECO:0000250|UniProtKB:Q81871}. Host Golgi apparatus {ECO:0000250|UniProtKB:Q81871}. Host cell surface {ECO:0000250|UniProtKB:Q68985}. Host nucleus {ECO:0000250|UniProtKB:Q81871}. Note=Translation from the internal AUG codon disrupts the signal sequence, producing a cytoplasmic protein that is responsible for virion assembly (By similarity). Shuttles between cytoplasm and nucleus (By similarity). This isoform is found in quasi-enveloped virions (By similarity). {ECO:0000250|UniProtKB:P33426, ECO:0000250|UniProtKB:Q81871, ECO:0000250|UniProtKB:Q9YLQ9}.
Interaction partners:
Sequence:
MRSRALLFLLFVLLPMLPAPPAGQPSGRRRGQAGCGGGFWGDRVDSQPFALPYIHPTNPFASDIPAAAGTGARPRQPIRPLGSAWRDQSQRPAASTRRRPAPAGASPLTAVAPAPDTAPVPDADSRGAILRRQYNLSTSPLTSTIATGTNFVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVVRATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASELVTPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSSARHKLRRGPDGTAELTTTAATRFMKDLHFTGTNGVGEVGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGELTVKLYTSVENAQQDKGVAIPHDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQTTYGSSTNPMYVSDTVTFVNVATGAQGVSRSLDWSKVTLDGRPLTTIQQYSKTFYVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQILIENAAGHRVCISTYTTNLGSGPVSVSAVGVLAPHSALAALEDTADYPARAHTFDDFCPECRALGLQGCAFQSTVGELQRLKMKVGKTREY
Protein: Protein DETOXIFICATION 16 (AtDTX16) (Multidrug and toxic compound extrusion protein 16) (MATE protein 16) (Q9FHB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Pentatricopeptide repeat-containing protein At1g03100
- At5g20030
- Protein kinase superfamily protein
- Heavy metal-associated isoprenylated plant protein 35
Sequence:
MRDDRERGEGDLSWPLIGEKSSVKEEVKKQLWLSGPLIAVSLLQFCLQVISVMFVGHLGSLPLSAASIATSFASVTGFSFLMGTASALDTLCGQAYGAKKYGMLGIQMQRAMFVLTLASIPLSIIWANTEHLLVFFGQNKSIATLAGSYAKFMIPSIFAYGLLQCFNRFLQAQNNVFPVVFCSGVTTSLHVLLCWVLVFKSGLGFQGAALANSISYWLNVVLLFCYVKFSPSCSLTWTGFSKEALRDILPFLRLAVPSALMVCLEMWSFELLVLLSGLLPNPVLETSVLSICLNTSGTMWMIPFGLSGAASTRISNELGAGNPKVAKLAVRVVICIAVAESIVIGSVLILIRNIWGLAYSSELEVVSYVASMMPILALGNFLDSLQCVLSGVARGCGWQKIGAIINLGSYYLVGVPSGLLLAFHFHVGGRGLWLGIICALVVQVFGLGLVTIFTNWDEEAKKATNRIESSSSVKDFAVDDRSVVVF
Protein: Zinc transporter ZIP6 (Endoplasmic reticulum membrane-linked protein) (Ermelin) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) (Q8C145)
Organism: Mus musculus (Mouse)
Function: May act as a zinc-influx transporter.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25143461}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13433}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q13433}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13433}. Membrane raft {ECO:0000250|UniProtKB:Q13433}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q4V887}. Note=Localizes to lipid rafts in T cells and is recruited into the immunological synapse in response to TCR stimulation (By similarity). In the choroid plexus is limited to the apical membrane in epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q13433, ECO:0000250|UniProtKB:Q4V887}.
Interaction partners:
- Proton-coupled zinc antiporter SLC30A5
- Zinc transporter ZIP1
- Proton-coupled zinc antiporter SLC30A1
- Zinc transporter 6
- Probable proton-coupled zinc antiporter SLC30A4
- Zinc transporter ZIP11
- Zinc transporter 7
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Probable proton-coupled zinc antiporter SLC30A3
- Proton-coupled zinc antiporter SLC30A2
Sequence:
MATDLSVIMILTFALWVTSPLHELQSTAAFSQTTEKINSNWEPGVNVDLAVTMQRHHLQQLFYRYGENDSLSVEGFRKLLQNIGIDKIKRVHIHHDHEHHADHEHHSDHEHHSDHEHHSDHEHHSDHEHHSDHEHHSHRSHTVAGKNNRKAFCPDLDSDNSGKNPRTSLGKGSRPAEHMNGRRNIKESASSSEVTSAVYNAVSEGTRFVETIETPKPGRRTKDVNPSTPPSITEKSRVGRLSRLARKKSNESVSEPRKSFMYSRNTNDNIQECFNTTKLLTSHGMSIQALLNATEFNYLCPAIINQIDARACLIHTASEKKAEIPPKTYSLQIAWLGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDALLHLLPHSHASHQHSHSHEEPAMEMKRGPLFSHLSAQNIEESSYFDSTWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKKNQKKPENDEDVESKKQLSKYDSQLSSNEEKVDPGERPESYLRADSQEPSPFDSQQPTMLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGIATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNAGILLGFGIMLLISIFEHKIVFRINF
Protein: GDNF family receptor alpha-4 (GDNF receptor alpha-4) (GDNFR-alpha-4) (GFR-alpha-4) (Persephin receptor) (Q9JJT2)
Organism: Mus musculus (Mouse)
Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
Subcellular location: [Isoform a1]: Cell membrane {ECO:0000305|PubMed:10860579}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9GZZ7}.; SUBCELLULAR LOCATION: [Isoform b1]: Cell membrane {ECO:0000305|PubMed:10860579}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9GZZ7}.; SUBCELLULAR LOCATION: [Isoform a3]: Secreted {ECO:0000305|PubMed:10860579}.; SUBCELLULAR LOCATION: [Isoform b3]: Secreted {ECO:0000305|PubMed:10860579}.
Interaction partners:
- Persephin
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Neurturin
- Artemin
- Growth/differentiation factor 15
- Glial cell line-derived neurotrophic factor
Sequence:
MAHCMESALLLLLLLGSASFTDGNRCVDAAEACTADERCQQLRSEYVARCLGRAAPGGRPGPGGCVRSRCRRALRRFFARGPPALTHALLFCGCEGSACAERRRQTFAPACAFSGPGLVPPSCLEPLERCERSRLCRPRLLAFQASCAPAPGSRDRCPEEGGPRCLRVYAGLIGTVVTPNYLDNVSARVAPWCGCAASGNRREECEAFRKLFTRNPCLDGAIQAFDSLQPSVLQDQTAGCCFPRVSWLYALTALALQALL
Protein: AT20168p (Uncharacterized protein, isoform G) (Q6NN86)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDASLEESMDSDGASSPITKTEATESPPEAGLNGNGSGSGSTSQETPNYGVAILKEKPSEAHRSKPFNAFSGRPIGEHTAQQQALQQQQLQQQQQPQQPQQQAPSGANGVTGPPEIWVETKAEDGRSYYYHAVTRETTWSRPDGPAVKIMTQAEVEEMAKRPAQAAKTEAKAGETSVEIPPVSSHLTSQPPPHLMSQPPPNAAAPLLSQPPPNVRQQPPPMFQPPGMQAPPGFGQPPFCMPPPTYGFPGGPAPAGAPWGVGIPPWQQQQHMQDKPAKSLIIKPGVIDPAVIARAAEWSEHRAPDGRPYYFHAGRGESVWEKPQALRDMEAARMAAHSGVAPAVATAPSGLPPHLLPNPMMHMPPGSGPPGFDPHAAFAAAAAAMKANSENTKAAQAAALEKEAKKAAEEKRKKEEEQKKAAASAKQTDKSRPVTSTPIAGTPWCVVWTGDSRVFFYNPSTRTSVWDRPEDLLNREDVDKAVNERPEQLKTPQEKSAEAEQKSGEEANQEQAKSQVQAQQLDQVQRVDADDDDDDEVIKIRTESESSVEEVPTKRVRMISKSKRAEDAALEAEQRAAKERALVPLEMRVTQFKEMLREKDVSAFSTWEKELHKIVFDPRYLLLTSKERKQVFEKYVKDRAEEERKEKRNKMRQKREDFRSLMEEARLHGK
Protein: Caveolin-3 (M-caveolin) (P51637)
Organism: Mus musculus (Mouse)
Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:26497963}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000269|PubMed:24066022}; Peripheral membrane protein {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000269|PubMed:24066022}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
Interaction partners:
- Dysferlin
- Caveolin-2
- Caveolin-1
- Tripartite motif-containing protein 72
- Proto-oncogene tyrosine-protein kinase Src
- Dystrophin
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Dystroglycan 1
- Caveolae-associated protein 1
- Alpha-sarcoglycan
Sequence:
MMTEEHTDLEARIIKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPEGTYSFDGVWKVSFTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSNIKVVLRREG
Protein: Lectin-1 (HCA) [Cleaved into: Lectin-1 N-terminal subunit; Lectin-1 C-terminal subunit] (P84870)
Organism: Hypnea cervicornis (Brazilian red alga)
Function: Lectin with specificity for complex N-linked glycans and O-linked glycans. Has hemagglutinating activity towards rabbit erythrocytes that is inhibited by N-acetyl-D-galactosamine.
Interaction partners:
Sequence:
QKACTMDYFPVCCQIVLGGGAYTAGNPCSCQGFVASKGTCDNPYPCPCTTEAQFPVCCTTQWGLVSATGNCACGCMGGVPVSDGPCPEVY
Protein: Anthranilate synthase component 1 (AS) (ASI) (EC 4.1.3.27) (P20580)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
Interaction partners:
- Anthranilate synthase component 2
- Anthranilate phosphoribosyltransferase
- Anthranilate synthase component 2, pyocyanine specific
- Indole-3-glycerol phosphate synthase
- Bifunctional chorismate mutase/prephenate dehydratase
- Tryptophan synthase alpha chain
- Tryptophan synthase beta chain
- anthranilate synthase
- Chorismate synthase
- GMP synthase
Sequence:
MNREEFLRLAADGYNRIPLSFETLADFDTPLSIYLKLADAPNSYLLESVQGGEKWGRYSIIGLPCRTVLRVYDHQVRISIDGVETERFDCADPLAFVEEFKARYQVPTVPGLPRFDGGLVGYFGYDCVRYVEKRLATCPNPDPLGNPDILLMVSDAVVVFDNLAGKIHAIVLADPSEENAYERGQARLEELLERLRQPITPRRGLDLEAAQGREPAFRASFTREDYENAVGRIKDYILAGDCMQVVPSQRMSIEFKAAPIDLYRALRCFNPTPYMYFFNFGDFHVVGSSPEVLVRVEDGLVTVRPIAGTRPRGINEEADLALEQDLLSDAKEIAEHLMLIDLGRNDVGRVSDIGAVKVTEKMVIERYSNVMHIVSNVTGQLREGLSAMDALRAILPAGTLSGAPKIRAMEIIDELEPVKRGVYGGAVGYLAWNGNMDTAIAIRTAVIKNGELHVQAGGGIVADSVPALEWEETINKRRAMFRAVALAEQSVE
Protein: Calcium-dependent cell adhesion molecule 1 (CAD-1) (DdCAD-1) (GP24) (P54657)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Mediates calcium-dependent cell-cell adhesion during the early stage of development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8663243}. Note=Associated with the ecto-surface of the plasma membrane. May be transported to the plasma membrane via contractile vacuoles and its cell surface association may be mediated by an integral membrane protein.
Interaction partners:
- Contact site A protein
- Tiger protein C1
Sequence:
MSVDANKVKFFFGKNCTGESFEYNKGETVRFNNGDKWNDKFMSCLVGSNVRCNIWEHNEIDTPTPGKFQELAQGSTNNDLTSINGLSKFQVLPGAFQWAVDVKIVNKVNSTAGSYEMTITPYQVDKVACKDGDDFVQLPIPKLTPPDSEIVSHLTVRQTHTPYDYVVNGSVYFKYSPTTGQVTVIKKDETFPKNMTVTQDDNTSFIFNLNSEK
Protein: Nuclear receptor corepressor 1 (J3QKP0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XDFARNQVSSQTPQQPPTSTFQNSPSALVSTPVRTKTSNRYSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGKSPERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQRGAEPAEQRNDARSPGSISYLPSFFTKLENTSPMVKSKKQEIFPAAQPGTEIFNLPAVTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSQPM
Protein: WAT1-related protein At1g44800 (Q9LPF1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein
- Protein GLUTAMINE DUMPER 1
- Amino acid permease 2
- Cationic amino acid transporter 8
- Amino acid permease 1
- O-fucosyltransferase 15
- Amino acid permease 5
- Amino acid permease 4
- Protein GLUTAMINE DUMPER 2
- Amino acid transporter ANT1
Sequence:
MKGGSMEKIKPILAIISLQFGYAGMYIITMVSFKHGMDHWVLATYRHVVATVVMAPFALMFERKIRPKMTLAIFWRLLALGILEPLMDQNLYYIGLKNTSASYTSAFTNALPAVTFILALIFRLETVNFRKVHSVAKVVGTVITVGGAMIMTLYKGPAIEIVKAAHNSFHGGSSSTPTGQHWVLGTIAIMGSISTWAAFFILQSYTLKVYPAELSLVTLICGIGTILNAIASLIMVRDPSAWKIGMDSGTLAAVYSGVVCSGIAYYIQSIVIKQRGPVFTTSFSPMCMIITAFLGALVLAEKIHLGSIIGAVFIVLGLYSVVWGKSKDEVNPLDEKIVAKSQELPITNVVKQTNGHDVSGAPTNGVVTST
Protein: CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320) (Q9NPF0)
Organism: Homo sapiens (Human)
Function: Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10727470, ECO:0000269|PubMed:11418631, ECO:0000305|PubMed:18779389}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Transcobalamin-2
- Lysosomal cobalamin transport escort protein LMBD1
- Methylmalonic aciduria type A protein, mitochondrial
- Cobalamin trafficking protein CblD
- Corrinoid adenosyltransferase MMAB
- Methionine synthase
- Methylmalonyl-CoA mutase, mitochondrial
Sequence:
MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP