wanglab/gogpt-training-data huggingface dataset:
Protein: Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (CAF-1 60 kDa subunit) (Chromatin assembly factor 1 subunit p60) (Q04199)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. p50 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in cell extracts (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Chromatin assembly factor 1 subunit A
- Histone-binding protein MSI1
- Histone chaperone ASF1
- Histone chaperone RTT106
- Histone H3
- Proliferating cell nuclear antigen
- Histone H4
- Bromodomain-containing factor 1
- Histone transcription regulator 3
- Protein HIR2
Sequence:
MEASHLQIYWHDSQPVYSLTFQKNSANDKLFTAGGDNKVRIWKLNRDENGQNGGVRKIESLDFLGSLTHHEQAINVIRFNSKGDVLASAGDDGQVLLWKQEDPNTQQESVVRPFGMDAETSEADENKEKWVVWKRLRGGSGATAAAEIYDLAWSPDNRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVYGVILSSAGVVTGLKLRSKIAKAELPCPGDVLRTNYLFHNETLPSFFRRCSISPCGGLVVIPSGVYKVAGDEVANCVYVYTRSGILNSAGGVKNRPAIRIPSLKKPALMAAFSPVFYETCQKSVLKLPYKLVFAIATTNEVLVYDTDVLEPLCVVGNIHYSPITDLAWSEDGSTLLISSTDGFCSYVSIDTETQFGSRIEPPAMHAEPLDTDESAVAAKNQREAGGIVNMLPVKKIPCNSSDSKKRRIHPTPVDL
Protein: Ankyrin repeat and MYND domain-containing protein 2a (Zgc:55491) (Q803N0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
Sequence:
MSAPKKGDLTDTEKELLQVIAAGNVQEASRLLGSKDVKVNCLDEYGMTPLMHAAYKGKADMCKLLLQHGADVNCNEHEHGYTALMFAGLSGKTEITWMMLDAGAETDAVNSVGRTAAQMAAFVGQHDCVTVINNFFSRARLDYYTKPQGLEKEPKLPPKLSGPLHKIIMSTNLNPVKIVMMVKENPLLMDVEALEKCRKVLELICEKCIKQQDMNEVLAMKMHYLSCVLQKCGSFLKDRQDKLESLIKSLLKGRDSDGFPVFQEKFIRECIRKFPYCDATLLQQLVRSIAPVEIGSDPTAMSVLTQAITGQVGFMDADFCTTCGEKGAEKRCSICKMVIYCGQACQKLHWFSHKKVCKMLQEQREKHEAESAARQKQAKAEGDQALEEMSSTMEDLSVSQNETTSSTDNHTEDVNSVTAD
Protein: Vitamin K epoxide reductase domain-containing protein (P95126)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVAARPAERSGDPAAVRVPVPSAWWVLIGGVIGLFASMTLTVEKVRILLDPIYVPSCNVNPIVSCGSVMTTPQASLLGFPNPLLGIAGFTVVVVTGVLAVAKVPLPRWYWIGLAVGILVGVAFVHWLIFQSLYRIGALCPYCMVVWAVIATLLVVVASIVFGPMRENRGSQERVGARLLYQWRWSLATLWFTTVFLLIMVRFWDYWSTLI
Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (Q95S66)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
Interaction partners:
Sequence:
MSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQQLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKRERSRGEALLVTWSRSTSASSIYRITDYGSKNQIITTIT
Protein: Ribonuclease H2 subunit B wHTH domain-containing protein (Q4GYF6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribonuclease
- Ribonuclease
- Proliferating cell nuclear antigen
Sequence:
MEWSRLTLLNRICHFLLLFFSSPHCLLSAMRAVKRNRQPSLQQPDGKTSAVAAPGRSEPPSSCSSDVGSPRRKLELDDEGSQSLLSNPSQPVASGGAVRYDVSDRTTPLPAGAHSSHMIVLPRSLLNYPLESVGGIPVGNGGLGGEHTNSINEVSNDGGMESLRSSGTLFPAASVGVSPGAGMQLCGPTFREVAVASVRKGCDFVRLPHPRHGEPALFLCPPATGEGENSDCSTHGAVLYEVQAQSPAEGFGQTWLVGELVEPNENLLIVTPFDCTFLALRQVSAHTMKDKFLPAEDLITGPVRSGACDSTWPGWGVALAQCPALAPAVQAMQSHTVLSRICDVKSVGDDSYYRFSTEKMGIWLKNKVKRAMASPGLRSLLELDKSGAENSDGGATEVPISVAFGVVAEYIPQDLCSTAAELCGTAET
Protein: Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (EC 5.4.3.8) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT) (P9WMN9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Delta-aminolevulinic acid dehydratase
- Glutamyl-tRNA reductase
- Possible thioredoxin protein
- Uncharacterized protein Rv0525
- Possible cytochrome C-type biogenesis protein CcdA
- Porphobilinogen deaminase
- Possible cytochrome C-type biogenesis protein CcsA
- Uroporphyrinogen decarboxylase
- Probable conserved transmembrane protein
- Phenyloxazoline synthase MbtB
Sequence:
MGSTEQATSRVRGAARTSAQLFEAACSVIPGGVNSPVRAFTAVGGTPRFITEAHGCWLIDADGNRYVDLVCSWGPMILGHAHPAVVEAVAKAAARGLSFGAPTPAETQLAGEIIGRVAPVERIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHVDALLADAGSGVATLGLCDDPQRPASPRSQSSRGLPSSPGVTGAAAADTIVLPYNDIDAVQQTFARFGEQIAAVITEASPGNMGVVPPGPGFNAALRAITAEHGALLILDEVMTGFRVSRSGWYGIDPVPADLFAFGKVMSGGMPAAAFGGRAEVMQRLAPLGPVYQAGTLSGNPVAVAAGLATLRAADDAVYTALDANADRLAGLLSEALTDAVVPHQISRAGNMLSVFFGETPVTDFASARASQTWRYPAFFHAMLDAGVYPPCSAFEAWFVSAALDDAAFGRIANALPAAARAAAQERPA
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (X2JE40)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MPAGRETVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELDFTVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLINDIERTMCREQKAQEDNRALLEKISDLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEANLQEVKALQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQLKSTHHEALANNRELQAQLEAEQCFSRLYKTQANENREESAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEETVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLLDKCKNEVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQDLQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETASLSSADNDPEDSQHSSLLSLTQDSVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERPGTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARLLKRIQKSGYKAASYNNNSTDGSKISPRSSGAAYKIPQR
Protein: Cysteine synthase 3 (EC 2.5.1.47) (O-acetylserine (thiol)-lyase 3) (OAS-TL) (O01592)
Organism: Caenorhabditis elegans
Function: Primarily catalyzes the formation of cysteine and acetate from O-acetylserine and hydrogen sulfide. Can also catalyze the formation of cysteine and acetate from S-sulfocysteine and hydrogen sulfide and the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide.
Interaction partners:
- Putative cystathionine gamma-lyase 2
- cystathionine gamma-lyase
- FAD/NAD
- Sulfide:quinone oxidoreductase, mitochondrial
- Probable phosphoserine aminotransferase
- Cysteine dioxygenase 1
- Kynurenine--oxoglutarate transaminase
- Kynurenine--oxoglutarate transaminase
- Adenosylhomocysteinase
- Aspartate aminotransferase, cytoplasmic
Sequence:
MSRELMVQDSGDTIGNTPLVLLRNISKGLDARIAVKVEYLNPSCSVKDRIAKSMVDEAEKAGTIVPGKTVLVEGTSGNLGIALAHIGKIRGYKVILVMPATMSVERRAMLRAYGAEVILSDPAEGHPGVIKKVEMLVDKLPNAHCLDQFSNPANPAAHYRTTGPEIWRQTEGKVDIVCFGVGSSGTVTGVGRYLREQNPNIEIYPVEPYESSVLSGLPRGPHKIQGIGAGIVPGNVDRSLFTEILRIKSDDAMQMARRLADEEAILGGISSGANVVAAVELASRPENKGKLIVTTVNSFAERYFTTELYSDVLNEVSQLTFSSDDEAMGIAKKYLGL
Protein: Serine hydroxymethyltransferase, cytosolic (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) (Q4KLG7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
PSENGDSLPLFGPLLLGGLCPARRSAGLAGLRTLLGGLSLLVYPDTGYINYDQLEENASLFHPKLIIAGTSCYSRNLDYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVRSVDPKTGEETYYELESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTTEFKIYQLQVLANCRALSDALTELGYKIVTGGSDNHLILMDLRPKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQKIAHFIHRGIELTLQIQSHMTMRATLKEFKEKLTGDEKFQSAVAALREEVENFASNFSLPGLPDF
Protein: 1,3,6,8-tetrahydroxynaphthalene synthase (THNS) (EC 2.3.1.233) (1,3,6,8-tetrahydroxynaphthalene synthesis polyketide synthase type III) (Q9FCA7)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Function: Involved in the biosynthesis of melanin but also various secondary metabolites containing a naphthoquinone ring. Catalyzes the iterative condensation of five CoA-linked malonyl units to form a pentaketide intermediate. THNS subsequently catalyzes the dual intramolecular Claisen and aldol condensations of this linear intermediate to produce the fused ring of 1,3,6,8-tetrahydroxynaphthalene (THN).
Interaction partners:
- Biflaviolin synthase CYP158A2
- Isoprenylcysteine carboxyl methyltransferase family protein
- Cupin type-1 domain-containing protein
- Oxidoreductase
- Polyketide synthase
- Rhodanese domain-containing protein
- DNA-directed RNA polymerase subunit beta
- Amino oxidase
- Glutamate--cysteine ligase EgtA
- DNA-directed RNA polymerase subunit omega
Sequence:
MATLCRPSVSVPEHVITMEETLELARRRHTDHPQLPLALRLIENTGVRTRHIVQPIEDTLEHPGFEDRNKVYEREAKSRVPAVIQRALDDAELLATDIDVIIYVSCTGFMMPSLTAWLINEMGFDSTTRQIPIAQLGCAAGGAAINRAHDFCTAYPEANALIVACEFCSLCYQPTDLGVGSLLCNGLFGDGIAAAVVRGRGGTGVRLERNGSYLIPKTEDWIMYDVKATGFHFLLDKRVPATMEPLAPALKELAGEHGWDASDLDFYIVHAGGPRILDDLSTFLEVDPHAFRFSRATLTEYGNIASAVVLDALRRLFDEGGVEEGARGLLAGFGPGITAEMSLGCWQTADVRRGIRQDVTRTAARGVSRRVRQA
Protein: Protein TIC110, chloroplastic (Translocon at the inner envelope membrane of chloroplasts 110) (AtTIC110) (Q8LPR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in protein precursor import into chloroplasts. Forms a voltage-dependent cation-selective channel at the inner envelope of chloroplasts, which specifically responds to a transit peptide. Associates with both the precursor and mature forms of the preprotein.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein TIC 40, chloroplastic
- Protein TOC75-3, chloroplastic
- Translocase of chloroplast 159, chloroplastic
- Protein TIC 22, chloroplastic
- Chaperone protein ClpC1, chloroplastic
- Short-chain dehydrogenase TIC 32, chloroplastic
- Protein TIC 55, chloroplastic
- Translocase of chloroplast 34, chloroplastic
- Protein TIC 62, chloroplastic
- Protein TIC 21, chloroplastic
Sequence:
MNPSLVTAINAPISPSPRSPLLSHFLPTLPHRFSKSECLSRRRYRVSFPRSSAASSDQLSVSTQAKNPGIHGNKKELTGLQPIVEKMTPPVRLATSAVVLAASLATGYGLGLRLAGSRNIAFGGAAVAGAAGGAVVYALNSAVPEVAAISLHNYVAEFEDPASVTKDDVEKIADRYGVNKGDEAFQAEICDIYCRYVTSVLPTEGQSLKGDEVAKIVKFKNALGIDEPDAAAMHMEIGRRIFRQRLETGEREGDAEQRRAFMRLVYVSALVFGDASSFLLPWKRVLKVTDAQVEIAIRENAKQLYAERLKLVGRDINVENLVDLRKSQLSFKLSDELAEDLFREHTRKVVVENISSALSILKSRTRAAKSLASVVEELEKVLEFNNLLVSLKSHSEADQFARGVGPISLIGDESDFERRMDDLKLLYRAYVTDALSGGRLEENKLVAMSQLRNILGLGKREAEAISVDVTSKSYRKRLANAVSSGDLEAQDSKAKYLQKLCEELHFDAQKAGAIHEEIYRQKLQQCVTDGELSDDNVAALLRLRVMLCIPQQTVDTAHAEICGTIFEKVVRDAISSGVDGYDAETRKSVRKAAHGLRLSRETAMSIASKAVRRVFTNYIRRARAAENRTDSAKELKKMIAFNTLVVTEMVADIKGESSDKAPEEDPVQEKEEDDEDEEWGSLESLRKTRPDKELAEKMGKPGQTEITLKDDLPDRDRIDLYKTYLLYCVTGEVTRIPFGAQITTKRDDSEYLLLNQLGGILGLSSKEIVNIHVGLAEQAFRQQAEVILADGQLTKARVEQLDELQKQVGLPQPQAEKVIKNITTTKMANAIETAVNQGRLNIKQIRELKEANVSLDSMIAVSLREKLFKKTVSDIFSSGTGEFDETEVYQTIPSDLSIDVEKAKRVVHDLAQSRLSNSLVQAVALLRQRNSKGVVLSLNDLLACDKAVPAEPMSWEVSEELSDLYAIYSKSDPKPAPEKVLRLQYLLGIDDSTATALREMEDGALSSAAEEGNFVF
Protein: Alpha/beta-Hydrolases superfamily protein (At3g10840) (A4IJ41)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein At5g03900
- Zinc finger/BTB domain protein
- 6,7-dimethyl-8-ribityllumazine synthase
- Inner membrane localized protein
- Low-density receptor-like protein
- Protein CHLOROPLAST J-LIKE DOMAIN 1
- Protein PAM71-homolog, chloroplastic
- Ribosomal RNA small subunit methyltransferase J
- Mitochondrial substrate carrier family protein
- Protein RETICULATA-RELATED 4
Sequence:
MNLNTTCIFFLNQPKQTLSTLSLSDKFSSDSSRTHFQMSRQISGQPSRRLIVSNAASSPSLSGGFPDAGAHSKEEMEAETEQDPMNLADPDSCFCEFQGVHIHHKVLDPHTLSDDVSNTSPHAQETPKTKFPMILLHGFGASVFSWNRVMKPLARLVSSKVLAFDRPAFGLTSRIFHPFSGATNDAKPLNPYSMVYSVLTTLYFIDVLAADKAILVGHSAGCPVALDAYFEAPERVAALILVAPAIFAPRPVATTDAGENRDKEAPTSNFLGTLVELTKGVIRAVLRVVTGMANMLSSLYKKALAAFLRSFLGVMLVRMAINKFGVTAVRNAWYDSKQVTDHVVQGYTKPLKAKGWDKALVEFTVATLTDNNGSEKKLPLSKRLQEIKCPVLIVTGDTDRIVPAWNAERLARAIPGSVFEVIKKCGHLPQEEKPDEFISIVAKFLGNAFGGSQQQDVDLKFQGIVS
Protein: PTS system mannose-specific EIID component (EII-M-Man) (EIID-Man) (Mannose permease IID component) (P69805)
Organism: Escherichia coli (strain K12)
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:31209249, ECO:0000269|PubMed:8774730}; Multi-pass membrane protein {ECO:0000269|PubMed:31209249}.
Interaction partners:
- PTS system mannose-specific EIIAB component
- PTS system mannose-specific EIIC component
- N-acetylgalactosamine permease IIC component 1
- Phosphocarrier protein HPr
- Mannose-6-phosphate isomerase
- Phosphomannomutase
- N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1
- N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 2
- PTS system glucose-specific EIICB component
- Fructokinase
Sequence:
MVDTTQTTTEKKLTQSDIRGVFLRSNLFQGSWNFERMQALGFCFSMVPAIRRLYPENNEARKQAIRRHLEFFNTQPFVAAPILGVTLALEEQRANGAEIDDGAINGIKVGLMGPLAGVGDPIFWGTVRPVFAALGAGIAMSGSLLGPLLFFILFNLVRLATRYYGVAYGYSKGIDIVKDMGGGFLQKLTEGASILGLFVMGALVNKWTHVNIPLVVSRITDQTGKEHVTTVQTILDQLMPGLVPLLLTFACMWLLRKKVNPLWIIVGFFVIGIAGYACGLLGL
Protein: GPI mannosyltransferase 1 (EC 2.4.1.-) (GPI mannosyltransferase I) (GPI-MT-I) (Glycosylphosphatidylinositol-anchor biosynthesis protein 14) (Q5AMR5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- GPI mannosyltransferase 2
- GPI mannosyltransferase 3
- GPI-anchored wall transfer protein 1
- Dolichol phosphate-mannose biosynthesis regulatory protein
- GPI-anchor transamidase
- Dolichol-phosphate mannosyltransferase subunit 1
- Dol-P-Man:Man
- Dolichol-phosphate mannosyltransferase subunit 3
- GPI mannosyltransferase 4
- Phosphatidylinositol N-acetylglucosaminyltransferase
Sequence:
MSQLKYLITFSILLRFGFFFFGLYQDEYMPVKYTDIDYLVFNDASKFVYQGLSPYLRETYRYTPILAILLIPDNFGKYWYHFGKLLFMVSDVITGLIILKLLSKQQQLSEKKKMILSSIWLLNPMVITISTRGSAESVLTVMIMLSLYYLLDKDNVILSAIWLGLSIHFKIYPIIYLPSILYYLSSQETPFLASVPGINLVNAKNLKYIIITLTTLAVVNYLMFLKYGWEFIDNSYLYHVTRLDHRHNFSVYNMVLYYKSALLEDSNGFDIEKIAFVPQLLLSAVIIPLIFAKEDLISSLFIQTFVFVAFNKVITSQYFIWFLIFLPHFLSKTKLLTTDKITGISCLLLWIISQATWLYFAYKLEFLGENTFDNGLMYSSVFFFLSNCWCTMKFIQSL
Protein: NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Q16288)
Organism: Homo sapiens (Human)
Function: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Neurotrophin-4
- Neurotrophic factor BDNF precursor form
- Receptor-type tyrosine-protein phosphatase S
- Neurotrophin-3
- Beta-nerve growth factor
- SHC-transforming protein 1
- Glial cell line-derived neurotrophic factor
- Transcription factor ETV6
- BDNF/NT-3 growth factors receptor
- Tumor necrosis factor receptor superfamily member 16
Sequence:
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
Protein: m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Protein PSU1) (mRNA-decapping enzyme subunit 2) (P53550)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast and occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Subcellular location: Cytoplasm, P-body {ECO:0000269|PubMed:12730603}.
Interaction partners:
- ATP-dependent RNA helicase DHH1
- LSM1-LSM7 complex subunit LSM1
- Protein SCD6
- 5'-3' exoribonuclease 1
- Deadenylation-dependent mRNA-decapping factor PAT1
- mRNA-decapping enzyme subunit 1
- Enhancer of mRNA-decapping protein 3
- Enhancer of mRNA-decapping protein 1
- Poly
- LSM complex subunit LSM4
Sequence:
MSLPLRHALENVTSVDRILEDLLVRFIINCPNEDLSSVERELFHFEEASWFYTDFIKLMNPTLPSLKIKSFAQLIIKLCPLVWKWDIRVDEALQQFSKYKKSIPVRGAAIFNENLSKILLVQGTESDSWSFPRGKISKDENDIDCCIREVKEEIGFDLTDYIDDNQFIERNIQGKNYKIFLISGVSEVFNFKPQVRNEIDKIEWFDFKKISKTMYKSNIKYYLINSMMRPLSMWLRHQRQIKNEDQLKSYAEEQLKLLLGITKEEQIDPGRELLNMLHTAVQANSNNNAVSNGQVPSSQELQHLKEQSGEHNQQKDQQSSFSSQQQPSIFPSLSEPFANNKNVIPPTMPMANVFMSNPQLFATMNGQPFAPFPFMLPLTNNSNSANPIPTPVPPNFNAPPNPMAFGVPNMHNLSGPAVSQPFSLPPAPLPRDSGYSSSSPGQLLDILNSKKPDSNVQSSKKPKLKILQRGTDLNSIKQNNNDETAHSNSQALLDLLKKPTSSQKIHASKPDTSFLPNDSVSGIQDAEYEDFESSSDEEVETARDERNSLNVDIGVNVMPSEKDSRRSQKEKPRNDASKTNLNASAESNSVEWGPGKSSPSTQSKQNSSVGMQNKYRQEIHIGDSDAYEVFESSSDEEDGKKLEELEQTQDNSKLISQDILKENNFQDGEVPHRDMPTESNKSINETVGLSSTTNTVKKVPKVKILKRGETFASLANDKKAFDSSSNVSSSKDLLQMLRNPISSTVSSNQQSPKSQHLSGDEEIMMMLKRNSVSKPQNSEENASTSSINDANASELLGMLKQKEKDITAPKQPYNVDSYSQKNSAKGLLNILKKNDSTGYPRTEGGPSSEMSTSMKRNDATNNQELDKNSTELLNYLKPKPLNDGYENISNKDSSHELLNILHGNKNSSAFNNNVYATDGYSLASDNNENSSNKLLNMLQNRSSAINEPNFDVRSNGTSGSNELLSILHRK
Protein: Protein OPI10 homolog (O60175)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus envelope {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MFGAICAGRLVQTNLQQVADNQFVFQLDSAESLNHIVVFLLPNSPFPVGMGAKVYFQWPGKPFQFLGYLTNEKPSAIFRLKNTIQTLSENENCVGITAMLGISVEPLTNFTETPAVSTSASNVIAKPLPPVTSVAQKILTNLYNFLASFATSQLPPNSIGLGDLRPNDTFIPLRVFQDWHAKFLNKLSNNPNFLDSEDQI
Protein: T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (P39076)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.
Subcellular location: Cytoplasm.
Interaction partners:
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit theta
- Phosducin-like protein 2
- Prefoldin subunit 4
- Prefoldin subunit 5
Sequence:
MSVQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRLKGSTNLEHIQIIKILGGKLSDSFLDEGFILAKKFGNNQPKRIENAKILIANTTLDTDKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTSGLDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRARPRTANRQHM
Protein: Zinc finger protein 223 (Q9UK11)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- HAUS augmin-like complex subunit 2
- Zinc finger protein 786
Sequence:
MTMSKEAVTFKDVAVVFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQPFHRDTFHFLREEKFWMMDIATQREGNSGGKIQPEMKTFPEAGPHEGWSCQQIWEEIASDLTRPQDSTIKSSQFFEQGDAHSQVEEGLSIMHTGQKPSNCGKCKQSFSDMSIFDLPQQIRSAEKSHSCDECGKSFCYISALHIHQRVHLGEKLFKCDVCGKEFSQSLHLQTHQRVHTGEKPFKCEQCGRGFRCRSALTVHCKLHMGEKHYNCEACGRAFIHDFQLQKHQRIHTGEKPFKCEICSVSFRLRSSLNRHCVVHTGKKPNSTGEYGKGFIRRLDLCKHQTIHTGEKPYNCKECGKSFRRSSYLLIHQRVHTGEKPYKCDKCGKSYITKSGLDLHHRAHTGERPYNCDDCGKSFRQASSILNHKRLHCRKKPFKCEDCGKKLVYRSYRKDQQKNHSGENPSKCEDCGKRYKRRLNLDIILSLFLNDT
Protein: 30 kDa heat shock protein (P40920)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Heat shock 70 kDa protein
- Class E vacuolar protein-sorting machinery protein hse1
Sequence:
MSLFRTIPTPGDFAPLFRLLDDYDNHRSARGHASVQSFAPRFDVRESNEAYHLDGELPGIPQSNIDIEFTDPQTLVIKGRSEREYHSSSDDNKNDQADTENQARGESSEVAKTGEKQVSTKKAANKSRYWVSERSVGEFQRTFTFPTRVNQDDVKASLKDGILSLVVPKAVPPTAKKITIQ
Protein: KinB-signaling pathway activation protein (P16449)
Organism: Bacillus subtilis (strain 168)
Function: Involved in the activation of the KinB signaling pathway of sporulation.
Subcellular location: Cell membrane {ECO:0000305|PubMed:8576055}; Multi-pass membrane protein {ECO:0000305|PubMed:8576055}.
Interaction partners:
- Kinase-associated lipoprotein B
- Cytochrome c biogenesis protein ResB
- Cytochrome c oxidase subunit 4B
- Uncharacterized protein YqgY
- Uncharacterized protein YphF
- Menaquinol:cytochrome c reductase cytochrome c subunit
- Uncharacterized protein YlbA
- UPF0295 protein YgzB
- Uncharacterized membrane protein YuiB
- Membrane protein YneK
Sequence:
MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQIFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDLMYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITALEWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK