Protein: Polyprotein pp220 (220 kDa polyprotein) [Cleaved into: p34; p14; p37; p150; p5] (Q08358)
Organism: African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)
Function: Essential for the core assembly. Its myristoyl moiety may function as a membrane-anchoring signal to bind the developing core shell to the inner viral envelope.
Subcellular location: [Polyprotein pp220]: Host cytoplasm, host perinuclear region {ECO:0000269|PubMed:9032369}. Note=Found in perinuclear cytoplasmic viral factories during assembly. {ECO:0000269|PubMed:9032369}.; SUBCELLULAR LOCATION: [p34]: Virion {ECO:0000269|PubMed:30185597}. Host cytoplasm, host perinuclear region {ECO:0000269|PubMed:12525602}. Note=Localizes to the viral factory at 16 hpi (PubMed:33429879). In the virion, located in the core shell, which functions like a matrix between the DNA-containing nucleoid and the inner envelope (PubMed:12438573). {ECO:0000269|PubMed:12438573, ECO:0000269|PubMed:33429879}.; SUBCELLULAR LOCATION: [p14]: Virion {ECO:0000269|PubMed:30185597}. Host cytoplasm, host perinuclear region. Note=Found in perinuclear cytoplasmic viral factories during assembly. In the virion, located in the core shell, which functions like a matrix between the DNA-containing nucleoid and the inner envelope (PubMed:12438573). {ECO:0000269|PubMed:12438573}.; SUBCELLULAR LOCATION: [p37]: Virion {ECO:0000269|PubMed:30185597}. Host cytoplasm, host perinuclear region {ECO:0000269|PubMed:17580096}. Host nucleus {ECO:0000269|PubMed:17580096}. Note=Found in perinuclear cytoplasmic viral factories during assembly. In the virion, located in the core shell, which functions like a matrix between the DNA-containing nucleoid and the inner envelope (PubMed:12438573). {ECO:0000269|PubMed:12438573}.; SUBCELLULAR LOCATION: [p150]: Virion {ECO:0000269|PubMed:12438573, ECO:0000269|PubMed:30185597}. Host cytoplasm, host perinuclear region {ECO:0000269|PubMed:12525602}. Note=Found in perinuclear cytoplasmic viral factories during assembly. In the virion, located in the core shell, which functions like a matrix between the DNA-containing nucleoid and the inner envelope (PubMed:12438573). {ECO:0000269|PubMed:12438573}.; SUBCELLULAR LOCATION: [p5]: Virion {ECO:0000269|PubMed:30185597}.
Interaction partners:
Sequence:
MGNRGSSTSSRPPLSSEANLYAKLQDHIQRQTRPFSGGGYFNGGGDKNPVQHIKDYHIDSVSSKAKLRVIEGIIRAIAKIGFKVDTKQPIEDILKDIKKQLPDPRAGSTFVKNAEKQETVCKMIADAINQEFIDLGQDKLIDTTDGAASICRQIVLYINSLTHGLRAEYLDVHGSIENTLENIKLLNDAIKQLHERMVTEVTKAAPNEEVINAVTMIEAVYRRLLNEQNLQINILTNFIDNILTPTQKELDKLQTDEVDIIKLLNDTNSVLGTKNFGKVLSYTLCNLGIAASVANKINKALQKVGLKVEQYLQSKNWAEFDKELDLKRFSGLVSAENIAEFEKAVNLLRQTFNERHKILENSCAKKGGDEEKTPLDRRIEAQRLDRKHILMEFLNKSTQAYNDFLENVKKIGIKLVKEIALTPNITRLRDALSRINDMGTIALDLSLIGFYTNAAAREERETFLTQFMLVKNVLEEQSKIDPNFKNLYDSCSRLLQIIDFYTDIVQKKYGGGEDCECTRVGGAALTVEELGLSKAARSQVDLNQAINTFMYYYYVAQIYSNLTHNKQEFQSYEENYATILGDAIAGRLMQLDTEKNARINSPAVDLARGHVGPNPGGAQEADWKAAVSAIELEYDVKRRFYRALEGLDLYLKNITKTFVNNIDSIQTVQQMLDGVRIIGRWFTEATGDTLAQVFESFPTSAGNDSNVFTDNAPAGHYYEKVAAEIQQGRSVGTLRPVRASQAKNIRDLIGRSLSNFQALKNIINAFARIGDMLGGEELRQMVPMSPLQIYKTLLEYIQHSALSVGLKNLNQSEIGGQRVALARTPEEAAQRVYLSTVRVNDALSTRWETEDVFFTFMLKSMAAKIFIVLGIYDMFERPEPVYKLIPTRMILGGADELEPEVIPEAAELYFRLPRLAEFYQKLFSFRDENVQISMLPELEGIFSGLIRIIFMRPIELINIGDYSETEIRQLIKEINVIYQHFNLEYGEQEATKKALIHFVNEINRRFGVITRTEWEKFQRIVQEARTMNDFGMMNQTNYSILPDEDGYTQSSQLLPSDRFISPSTQPTPKWRPALYNIDSVDVQTGMLQPNSQWDLVQKFRKQLSEMFEDPSLQQELGKVSYQELIRQAINELKKEHTDKIQIVSKLIQGSESLADTDVNKIFLFHETVITGLNLLSAIYVLLNNFRNNIKGLDLDTIQKSIIEWLRETQAANVNRANLIDWLGRKHGAISEIRNPGLVVKENDVRLSRVYPDPTTNATAPQDQNLVTETLFAWIVPYVGIPAGGGVRAEQELAARYLVDNQRIMQLLLTNIFEMTSSFNKMVQVRFPETSTAQVHLDFTGLISLIDSLMADTKYFLNLLRPHIDKNIIQYYENRSNPGSFYWLEEHLIDKLIKPPTDAGGRPLPGGELGLEGVNQIINKTYILLTKPYNVLQLRGGVQRRDAANIQINNNPQPSERFEQYGRVFSRLVFYDALENNSGLRVEQVVLGDFRLSNLIRTNNAQEENTLSYWDNMAPRTYANVNDAANNLRRYRLYGSDYGIQNNRSMMMVFNQLVASYIARFYDAPSGKIYLNLINAFANGNFSQAVMELGYTHPDLARDNIAFGHRGDPTEQSVLLLSLGLMLQRLIKDTNRQGLSQHLISTLTEIPIYLKENYRANLPLFNKMFNILISQGELLKQFIQYTNVQLARPNLMGLLGANNDSVIYYNNNINVPMTGLSVGQAALRGIGGVFRPNVTLMPLGDAQNNTSDVVRKRLVAVIDGIIRGSHTLADSAMEVLHELTDHPIYLETEEHFIQNYMSRYNKEPLMPFSLSLYYLRDLRIENNEVYDPLLYPNLESGSPEFKLLYGTRKLLGNDPVQLSDMPGVQLIMKNYNETVVAREQITPTRFEHFYTHAIQALRFIVNIRSFKTVMMYNENTFGGVNLISENRDDKPIITAGIGMNAVYSLRKTLQDVISFVESSYQEEQINHIHKIVSPKGQTRTLGSNRERERIFNLFDMNIIPINVNALMRSIPLANIYNYDYSFEEIACLMYGISAEKVRSLNTAAPQPDIAEVLNIPNRPPMNTREFMLKLLINPYVSVSITQYGNELMSKGSAGYMSRIFRGDNALNMGRPKFLSDQIFNKVLFGSLYPTQFDYDEAGPGLAAGIQRGREQWGQPLSEYINQALHELVRTIRIPQKLRVLRNIIVKNQLIADLTTIREQLVSMRREVENMIQTPEIQNNPTPEVIAAAQNWTQQYRARVDTLINFIGNIGQPNSMLDLIQTITPVTVRAQLGVIFNRHGIPVPHPRQILQTDDEATQWFMTNILNIPAIIMTPFTDLANDLRTFLETLERYVFNVPRWLGPSTGRVARAPVRMAPRDMRHPISYTENSVLTYITEQNREEGPWSIVKQVGVGIQKPTLVQIGKDRFDTRLIRNLIFITNIQRLLRLRLNLELSQFRNVLVSPDHIINPSITEYGFSITGPSETFSDKQYDSDIRIL