wanglab/gogpt-training-data huggingface dataset:
Protein: Amine oxidase (EC 1.4.3.-) (D3ZVN7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Ferrochelatase
- Uroporphyrinogen decarboxylase
- Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
- Uroporphyrinogen-III synthase
- Delta-aminolevulinic acid dehydratase
- Endonuclease V
- Porphobilinogen deaminase
- Inter-alpha-trypsin inhibitor heavy chain 5
- UDP-glucose 4-epimerase
- 5-aminolevulinate synthase, non-specific, mitochondrial
Sequence:
MARTVIVLGGGISGLAASYHLTRSPSPPKVILVEGSKRLGGWIRSVRGSDGAIFELGPRGIRPAGALGARTLLLFLLFLRACGEQVSELGLESEVLPVRGDHPAAQNRFLYVGGALHPLPSGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSQELSIRSCFPSLFQAEQTHGSMLLGLLLGAGQTPQPNSSLIRQARAERWSQWSLRGGLEMLPQALHNYLTSKGVTILSGQPACGLSLQPEGHWKVSLGDSSLEADHIISTIPASVLSKLLPAEAAPLAHILSTIQAVSVAVVNLQYKGACLPVQGFGHLVPSSEDPTVLGIVYDSVAFPEQDGNPPGLRLTVMLGGYWLQKLKANGHELSPELFQRAAQEAAATQLGLKEQPSHCLVHLHKNCIPQYTLGHWQKLDSALQFLTAQRLPLTLAGASYEGVAVNDCIESGRQAAIAVLGTESNS
Protein: [histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68) (A0A8I6GMK8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MQMPVKFDILRISGNEEKKMAAEKARGEGEEGSFSLTVEEKKALCGLDSSFFGFLSLCKDGVKMKTLLNKAIHCYESLIVKAEGKVESDFFCQLGHFNLLLEDYSKALSSYQRYYSLQTDYWKNAAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPNFCRAKEIHLRLGFMFKVNTDYESSLKHFQLALRDSNVCTLSSVEIQFHIAHLFEIQRKYHSAKAAYEQLLQIESLPSQVKATVLQQLGWMHHNMDLVGDNTTKERYAIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQTQDAIKCYLNATRSKSCSNTSVLISRIKFLQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNVSDSWNSVHTASHHPVQQQVYTQCFTTQKLQGLGKDQQRPFQTGSTRYIHAACVDNQNQNGNHTLPQNSKGDTQNHSSLHIPTSEEQKIFNFTKESKDSRSKSLSPKTSRQDRDTSNIYVNAKEHSKNIHEITSVPISSLNNEDSVSPNLIIVDNPQLSVLVGEAMDSVDHDSRTCDKVNNVHPTLHKKPDNLTASSPSSASSTETLSLKVTEQMHTHIVTSFISPNSGLDTINGGPENSESSISVSVGLRPRPQIIPSMSVSIYSSSTEVLKACRNLGKNGLSNGHILLDICPPPRPPTSPYPPLPKEKLNPPTPSIYLENKRDAFFPPLHQFCINPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHIVEVRTQFLQPADENWDPSGTKKIWRYENKSSHTTIAKYAQYQACSFQESLREENERKTQVKDYSDNESTCSDISRRRQKVPFKTIKCGINIDLSDNKKWKLQLHELTKLPAFVRVVSAGNLLSHVGYTILGMNSVQLCMKVPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNVGPLTAFQYKLAVERYEWNKLQSIKSVVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQCQTLREALVAAGKEVLWHGRINDEPAPYCSICEVEVFNLLFVTNESNSQKTYIVHCQNCARKTSGNLENFVVLEQYKMEDLIQVYDQFTLAPSLSSSS
Protein: CLK4 associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16 (Suppressor-of-white-apricot homolog, Drosophila), isoform CRA_b) (F5H0Q6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAEVEKAAEKPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVRMLRKDKEEAEAIKHAKALEEEKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKVIKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWERQYSRQSRSPSPRYSREYSSSRRRSRSRSRSPHYRH
Protein: Zinc finger protein 385D (Zinc finger protein 659) (Q9H6B1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MRNIMYFGGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLKALEAMKNKQKSVTAKDSAKTTFTSITTNTINTSSDKTDGTAGTPAISTTTTVEIRKSSVMTTEITSKVEKSPTTATGNSSCPSTETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGTIKAFPRAGVKGKGPVNKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKTAHPLGVKLVFSKEPSKPLAPRILPNPLAAAAAAAAVAVSSPFSLRTAPAATLFQTSALPPALLRPAPGPIRTAHTPVLFAPY
Protein: Dipeptidyl aminopeptidase 4 (EC 3.4.14.5) (Dipeptidyl aminopeptidase IV) (DAP IV) (Q6F3I7)
Organism: Pseudoxanthomonas mexicana
Function: Catalyzes the sequential release of Tyr-Pro, Phe-Pro and Gly-Pro from the N-terminus of peptides and proteins. Is able to cleaves bioactive peptide beta-casomorphin.
Subcellular location: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15866709}.; SUBCELLULAR LOCATION: [Isoform 1]: Periplasm {ECO:0000269|PubMed:15866709}.
Interaction partners:
Sequence:
MRLALFALFALMTVATALPAHAEKLTLEAITGSAPLSGPTLTKPQIAPDGSRVTFLRGKDRDRNRLDLWEYDIASGQTRLLVDSSVVLPGEEVLSDEEKARRERQRIAALSGIVDYQWSPDGKALLFPLGGELYFYDLTKSGRDAVRKLTNGGGFATDPKISPKGGFVSFIRDRNLWAIDLASGKEVQLTRDGSDTIGNGVAEFVADEEMDRHTGYWWAPDDAAIAFARIDETPVPVQKRYEVYPDRTEVVEQRYPAAGDHNVRVQLGVIAPKTGARPRWIDLGKDPDIYLARVDWRDPQRLTFQRQSRDQKKIELIETTLTNGTQRTLVTETSTTWVPLHNDLRFLKDGRFLWSSERSGFEHLYVASEDGSTLTALTQGEWVVDSLLAIDEAAGLAYVSGTRDGATEAHVYAVPLSGGEPRRLTQAPGMHAATFARNASVFVDSWSSDTTLPQIELFKADGTKLATLLVNDVSDATHPYAKYRAAHQPTAYGTLTAADGTTPLHYSLIKPAGFDPKKQYPVVVFVYGGPAAQTVTRAWPGRSDSFFNQYLAQQGYVVFTLDNRGTPRRGAAFGGALYGKQGTVEVDDQLRGIEWLKSQAFVDPARIGVYGWSNGGYMTLMLLAKHDEAYACGVAGAPVTDWALYDTHYTERYMDLPKANEAGYREASVFTHVDGIGAGKLLLIHGMADDNVLFTNSTKLMSELQKRGTPFELMTYPGAKHGLRGSDLLHRYRLTEDFFARCLKP
Protein: Neurofilament medium polypeptide (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) (E7ESP9)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD
Protein: RRM domain-containing protein (Q57W53)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Probable eukaryotic initiation factor 4A
- ATP-dependent RNA helicase
- KRR1 small subunit processome component
- U3 small nucleolar RNA-associated protein 25
- ESF1 RRM domain-containing protein
- Bystin, putative
- Nop14-like protein
- U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein
- U3 small nucleolar RNA-associated protein 18
- MI domain-containing protein
Sequence:
MLDTSGSPDGFGDYTAPSKRGVLFFSTVPRDMRPQEVERHFGRFGTITRRKFTPFPRKERRPNGPLLPLQFMRGYIEFSKAEDAEYAAAAMNGTPVDCKRRRRCSGQLWTVKYEKGFTWDVLLEEREAAVRSRRQREVEARSQEREINEAFRAAVAKRLASRAKNRKGDGAAKVSTAGGGETLVNRDDNSKCKREPGNDDVDESRTKRKRSRVEATSSTSDATNASKDLKKKKVKKN
Protein: short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) (Butyryl-CoA dehydrogenase) (E5KSD5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
Protein: Uncharacterized protein (Q388S4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MMSSRSVAKVVVAAAIGYVAYRGVLSFFKNEITLSISEVVHMSDGQCRQEIGDQVALKGEILCETYLMRSYRLSMKLSANIKGGTLSLSSHVPSRHRVLHINDVGTYCNVVPSSGSKRRDGLPDIVVDNVHGMVDYWELLSCGNVCFTPPCVSDESVLRYEGKVRPGLSPSATIRDCYLQTDETPGRKRLHFDLIVRDTVHAVSIRIELPNRRCQLVLVDHGGVGSVTRLSKEASHCWAWDIPLFDPRGASREIPTAADEASITKPGSYPHGAMQETLVGALGSDLPEYTPSACTHFMLIFEEQEGGDNSDASTNSDMDGENVEEGFDELKDSPEGSSEMVTSNRAQKVSKKAMKRAERSRKKVTQRQRVDAIRTSRQGAVARGVAVSLSYSVSGLASGMDVRRLRTVSERPNWAPHSNFSRWILSFLSWCIYKPRLGKFAHYTTWFVQTVDVISL
Protein: Catabolite control protein A (Q2G295)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Interaction partners:
- Glutamate synthase, large subunit, putative
- PTS system glucoside-specific EIICBA component
- Phosphocarrier protein HPr
- Pyruvate kinase
- PTS system glucose-specific EIICBA component
- Global transcriptional regulator CodY
- Protein GlcT
Sequence:
MTVTIYDVAREARVSMATVSRVVNGNQNVKAETKNKVNEVIKRLNYRPNAVARGLASKKTTTVGVIIPDISNIYYSQLARGLEDIATMYKYHSIISNSDNDPEKEKEIFNNLLSKQVDGIIFLGGTITEEMKELINQSSVPVVVSGTNGKDAHIASVNIDFTEAAKEITGELIEKGAKSFALVGGEHSKKAQEDVLEGLTEVLNKNGLQLGDTLNCSGAESYKEGVKAFAKMKGNLPDAILCISDEEAIGIMHSAMDAGIKVPEELQIISFNNTRLVEMVRPQLSSVIQPLYDIGAVGMRLLTKYMNDEKIEEPNVVLPHRIEYRGTTK
Protein: Protein ORF45 (F5HDE4)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Prevents the establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of host interferon regulatory factor 7/IRF7, a transcription factor critical for the induction of interferons alpha and beta. Mechanistically, ORF45 competes with the associated IRF7 and inhibits its phosphorylation by IKBKE or TBK1 by acting as an alternative substrate. Acts as an activator of the NLRP1 inflammasome via interaction with the N-terminal part of host NLRP1: interaction promotes translocation of the N-terminal part of NLRP1 into the nucleus, relieving autoinhibition of the NLRP1 inflammasome and leading to its activation. Also plays a role in promoting the late transcription and translation of viral lytic genes by constitutively activating host extracellular signal-regulated kinase (ERK)-p90 ribosomal S6 kinase/RPS6KA1. In addition, supports the viral replication cycle by modulating host p53/TP53 signaling pathway. Interacts with host p53/TP53 and prevents its interaction with the deubiquitinase USP7, leading to sequestration of P53/TP53 in the host cytoplasm thereby diminishing its transcriptional activity.
Subcellular location: Virion tegument {ECO:0000269|PubMed:12634379}. Host cytoplasm {ECO:0000269|PubMed:19116250}. Host nucleus {ECO:0000269|PubMed:19116250, ECO:0000269|PubMed:35618833}. Host Golgi apparatus {ECO:0000269|PubMed:33315947}.
Interaction partners:
Sequence:
MAMFVRTSSSTHDEERMLPIEGAPRRRPPVKFIFPPPPLSSLPGFGRPRGYAGPTVIDMSAPDDVFAEDTPSPPATPLDLQISPDQSSGESEYDEDEEDEDEEENDDVQEEDEPEGYPADFFQPLSHLRPRPLARRAHTPKPVAVVAGRVRSSTDTAESEASMGWVSQDDGFSPAGLSPSDDEGVAILEPMAAYTGTGAYGLSPASRNSVPGTQSSPYSDPDEGPSWRPLRAAPTAIVDLTSDSDSDDSSNSPDVNNEAAFTDARHFSHQPPSSEEDGEDQGEVLSQRIGLMDVGQKRKRQSTASSGSEDVVRCQRQPNLSRKAVASVIIISSGSDTDEEPSSAVSVIVSPSSTKGHLPTQSPSTSAHSISSGSTTTAGSRCSDPTRILASTPPLCGNGAYNWPWLD
Protein: Eukaryotic translation initiation factor 4E-1 (eIF-4E-1) (eIF4E-1) (eIF-4F 25 kDa subunit) (eIF-4F p26 subunit) (mRNA cap-binding protein) (Q0GRC4)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Key component of recessive resistance to potyviruses.
Subcellular location: Nucleus {ECO:0000269|PubMed:21283665}. Cytoplasm {ECO:0000269|PubMed:21283665}. Note=(Microbial infection) Binds to potyvirus viral genome-linked protein (VPg) in the nucleus and with potyvirus nuclear inclusion protein A (NIa-Pro) and nuclear inclusion protein B (NIb) in the cytoplasm. {ECO:0000269|PubMed:21283665}.
Interaction partners:
Sequence:
MVVEDTPKSIITDDQITTNPNRVIEDDNNLEEGEILDEDDSSATSKPVVHQPHLLENSWTFLFDTPAAKSKQDDWGSSMRPIYTFSTVEEFWSIYNNIHHPGKLAVRADFYCFKHKIEPKWEDPICANGGKWTANYPKGKSDTSWLYTLLAMIGEQFDHGDEICGAVVKVRGRAEKISIWTKNASNEAAQVSIGKQWKEFLDYNETMGFIFHDDARKLDRNAKNKYVV
Protein: Ranakinin-N (P86093)
Organism: Hylarana nigrovittata (Black-striped frog) (Sylvirana nigrovittata)
Function: Induces contraction of intestinal smooth muscle in isolated guinea pig ileum. May induce relaxation of arterial smooth muscle. May target bradykinin receptors (BDKRB). Lacks antibacterial activity against the Gram-positive bacterium S.aureus and the Gram-negative bacteria E.coli and B.dysenteria, and antifungal activity against C.albicans.
Subcellular location: Secreted {ECO:0000269|PubMed:17994619}.
Interaction partners:
Sequence:
MFTMKKSLLLLFFLGTISMSLCEEKRDADEEETEGEAKMEDIKRAEAVPPGFTPFRKP
Protein: GM03767p (Mitochondrial ribosomal protein L12) (RE53508p) (Q9VSR5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL21m
- DSec61alpha
- Elongation factor Ts, mitochondrial
- 40S ribosomal protein S15
- Small ribosomal subunit protein bS16m
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein uS9m
- FI01658p
Sequence:
MHITRLALRQISRQVQLHRMYSAAAPAAAVSGAEKLVPPAPEGAAKPPNPKLDSIVNNIAALNLLEVAELSTLLKQKLNLPETAFAPQFAAGPARAAPAEDEEEAAPKKVQTSFKVKLVKFDEKQKVALIKEVKNLLEGMNLVQAKKFVESAPTIVKEDIPKEEAEKLKEALSKAGAIIEIE
Protein: Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1) (Q9Y5J3)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. Involved in the regulation of liver cancer cells self-renewal.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:26068074}.
Interaction partners:
- S-phase kinase-associated protein 1
- Hairy/enhancer-of-split related with YRPW motif protein 2
- Cullin-1
- Neurogenic locus notch homolog protein 1
- Hairy/enhancer-of-split related with YRPW motif-like protein
- Protein jagged-1
- Recombining binding protein suppressor of hairless
- Transcription factor HES-1
- Neurogenic locus notch homolog protein 4
- Neurogenic locus notch homolog protein 3
Sequence:
MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTEIGAF
Protein: Transcription factor ATOH7 (Atonal bHLH transcription factor 7) (Class A basic helix-loop-helix protein 13) (bHLHa13) (Protein atonal homolog 7) (Q8N100)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3'. Dimerization with TCF3 isoform E47 may be required in certain situations. Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (By similarity). Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (By similarity). Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (By similarity). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:31696227}. Perikaryon {ECO:0000250|UniProtKB:Q9Z2E5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2E5}.
Interaction partners:
- Growth/differentiation factor 11
- POU domain, class 4, transcription factor 2
- Visual system homeobox 2
- Visual system homeobox 1
Sequence:
MKSCKPSGPPAGARVAPPCAGGTECAGTCAGAGRLESAARRRLAANARERRRMQGLNTAFDRLRRVVPQWGQDKKLSKYETLQMALSYIMALTRILAEAERFGSERDWVGLHCEHFGRDHYLPFPGAKLPGESELYSQRLFGFQPEPFQMAT
Protein: Auxin response factor 22 (Q9C8N7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Auxin-responsive protein IAA34
- Auxin-responsive protein IAA32
- Auxin-responsive protein IAA8
- Auxin-responsive protein IAA27
- Auxin-responsive protein IAA10
- Auxin-responsive protein IAA16
- Auxin-responsive protein IAA5
- Auxin-responsive protein IAA9
- Auxin-responsive protein IAA11
- Auxin-responsive protein IAA7
Sequence:
MESGNIVNAQPELSGIIDGSKSYMYEQLWKLCAGPLCDIPKLGEKIYYFPQGNIELVEASTREELNELKPICDLPSKLQCRVIAIQLKVENNSDETYAEITLMPDTTQVVIPTQNENQFRPLVNSFTKVLTASDTSGGFFVPKKHAIECLPPLDMSQPLPTQELLATDLHGNQWRFNHNYRGTPQRHLLTTGWNAFTTSKKLVAGDVIVFVRGETGELRVGIRRAGHQQGNIPSSIISIESMRHGVIASAKHAFDNQCMFIVVYKPRSSQFIVSYDKFLDAVNNKFNVGSRFTMRFEGDDFSERRYFGTIIGVSDFSPHWKCSEWRNLEVQWDEFASFSRPNKVSPWEIEHLMPALNVPRPSLLKNKRLREVNEIGSSSSHLLPPILTQGQEIGQLSVASPMNISLTYRDTTEDVMNPSRLLMSYPVQPMPKLNYNNQMVTQIEENITTKTGTNFRLFGVSLVTPSVIKDPIEEIGSEISKLTEGKKFGQSQTLRSPTEIQSKQFSSTRTCTKVQMQGVTIERAVDLSVLNGYDQLILELEELFDLKGQLQTRNQWEIAFTDSDDDKMLVGDDPWPEFCNMVKKILIFKRGGQKLEVQ
Protein: Nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1) (EC 2.7.7.18) (A0A8I6ANE3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MPALWNPDHNNIGIRGLHLDQQLQLLPMDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYLNATGEYKVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRHHQEKLATGSRSHPQSSPVLERPGRKRKWADQKQDSSPQKPQEPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICVTRAGSDAQKFIYESDVLWRHQSNIHLVTEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEEHDLYNSESEDRNAGVTLAPLQRNTSEAKHNHSTR
Protein: BTB domain-containing protein (O16612)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSGNTVKLNVGGTVFETLKSTLTKHDGFFKALIETDVPAEKDDSNCFFIDRSPKHFETVLNYMRSGDVVLPDSKKDMLELKKEAEYYLLSNLAKLCQPPTDNFKTCTPEELMRVVANTDKKVIMINYLTYNGELVFYPWGFNLVHFLIQNRDYVEDVYFRRTESQYPEDGPFPNEKPYWTFLVYNSTRSGRRPFRHTVDLEDCMGHM
Protein: Probable endo-1,3(4)-beta-glucanase AFUA_2G14360 (EC 3.2.1.6) (Mixed-linked glucanase AFUA_2G14360) (Q4X084)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Endo-1,3
Sequence:
MAPSSLLLSVGSLITSSLVSATALEARQSQTYQLAESWQGESFINDWNFFDGADPTNGYVTYVNQSFAKQSGLVKVTESGSFYMGVDYESTLNPNGAGRESVRIESKNYYTEGLYVIDIEHMPGSICGTWPAFWSVGKNWPNDGEIDIIEGVNLQKANKIVLHTSGSCDVSGSNDMTGTLSSSECGEASGTVGCVVKGTNGSSGDPFNESGGGVYAMEWTDTFIKIWFFPRSQIPASLASGNPDTSSFGTPMAHLQGSCDFAERFKAQKLIIDTTFCGDWAGNVFAESTCPMSDPSSPMQSCVNYVAQNPAAFKEAYWEINSIKIYQYGVSAASSAAVSQATASKVEGTRVSAQAANTATPTVPAPVETTTVPQPAQTNTVATSAADHATPSSAETTTVPAATGAPSVSATEGGDSELESTSTVYVTSTTTICPVAESSSAAAAGGKEDAPSNGTSGAEVAATSVAAAAPAAATSGHPGADAIANSAAATSTDAQSESATSRLTAGALSEIPTAPPEPVSQAVSTGSFDDSDTAQGDSEEQGSIASASVAPSTIPVPASSSAAALGGSSIASSFASSRLIPRPTGSSTAASATAIATWSPTAGESASGTAKESATLTTPSEVFFTPGLSNGANRMSVGLSGLIGVMFIAALA
Protein: Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK) (Q922S8)
Organism: Mus musculus (Mouse)
Function: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q99661}. Nucleus {ECO:0000250|UniProtKB:P70096}. Chromosome, centromere {ECO:0000250|UniProtKB:Q99661}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q99661}. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1. Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2A. {ECO:0000250|UniProtKB:P70096, ECO:0000250|UniProtKB:Q99661}.
Interaction partners:
- Serine/threonine-protein kinase PLK1
- Cell division cycle protein 20 homolog
- Centromere-associated protein E
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Aurora kinase B
- Kinesin-like protein KIF18B
- Centromere protein F
- Kinesin-like protein KIF20A
- Disks large-associated protein 5
Sequence:
MESLHARLFPGLSINIQRSNGLIHPANISTVNVEKSCVSVEWIEGGTTKGKEIDIDDVAAINPELLQLLPLRPKDSLPLQENVTVPKQKRKSVNSKIPALKEGLRSRSTRMSTVSEVRIPAQENEMEVELPVPTNSRKQFAIPSHPRASCSTVTELPLLMVSEEAEEQAHSTRSTSSANPGNSVRRKSCIVKEMEKMKNKREEKRAQNSELRIKRAQEYDSSFPNWEFARMIKEFRVTMECSPLTVTDPIEEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNASKGIYAMASRDVFLLKNQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSRQQVQVVGLQEYLVTCADDVIKMINMGSACRTSGQTFANSNSSRSHACFQILLRTKGRLHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQPVQMETEVMEASSNGTSLTGNEEEELSSQMSSFNEAMTQIRELEERALEELREIIQQGPNWLELSEMTDQPDYDLETFVNKAESALTQQAKQAKHFSALREVIKALRLAMQLEEQASKQINSKKRHQ
Protein: Abl interactor 2 (E7EW77)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSADKQRALEETKAYTTQSLASVAYLINTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANLERPVRYIRKPIDYTILDDIGHGVKWLLRFKVSTQNMKMGGLPRTTPPTQKPPSPPMSGKGTLGRHSPYRTLEPVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVFPDAAAGGAQTLADGFTSPTPPVVSSTPPTGHPVQFYSMNRPASRHTPPTIGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPVSDTPPPPPPVEEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESIMHYSE
Protein: LD31163p (Sunspot) (Q9VTT3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIEARTMQDVSKFESNQVISAKVLRGEYRLLRRKQRGSVWKVYREIVRTDGAIINGLYFCTGCKRVMRSFNTSNLRTHKCHVDYLRTEELCEEGIAEIHPPKLDDSLERRLSWNSFQPSEWSFHAVELLLELWARHCVDLRDSRKRVQVIWKMTGEMKSLGFTFTEIKNKIDDMGQQYRRESHMEKTTGHKSQWEYFETMKMIFSSDRNIIDNMPLDKSGSAPNTTSEHNSFGSQLDEPLIDRNYLRSQKVHPGEGDSFDMNEYADEAQEDVDELRILKDNIIREIEESSTVHSQENYEDELDQQNSKTEDMKIAKRQRAARIMEIEEEKLVIERKKCKLMKFFVREMSSFHKDFMDLLSNPKGGAHA