wanglab/gogpt-training-data huggingface dataset:
Protein: Autotaxin (EC 3.1.4.39) (EC 3.1.4.4) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2) (E-NPP 2) (Extracellular lysophospholipase D) (LysoPLD) (Q9R1E6)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition (By similarity). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:17208043, ECO:0000269|PubMed:19329427, ECO:0000269|PubMed:21240269}.
Interaction partners:
- Lysophospholipase D GDPD3
- Lysophospholipase D GDPD1
- Lysophosphatidic acid receptor 1
- Lysophosphatidic acid receptor 2
- Lysophosphatidic acid receptor 3
- Lysophosphatidic acid receptor 4
- Lysophosphatidic acid receptor 6
- Lysophosphatidic acid receptor 5
Sequence:
MARQGCFGSYQVISLFTFAIGVNLCLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTLPEEVSRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLVKKYASERNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI
Protein: Glutathione S-transferase (EC 2.5.1.18) (O24595)
Organism: Zea mays (Maize)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|RuleBase:RU369102}.
Interaction partners:
Sequence:
MAEEKKQGLQLLDFWVSPFGQRCRIAMDEKGLAYEYLEQDLGNKSELLLRANPVHKKIPVLLHDGRPVCESLVIVQYLDEAFPAAAPALLPADPYARAQARFWADYVDKKLYDCGTRLWKLKGDGQAQARAEMVEILRTLEGALGDGPFFGGDALGFVDVALVPFTSWFLAYDRFGGVSVEKECPRLAAWAKRCAERPSVAKNLYPPEKVYDFVCGMKKRLGIE
Protein: Protocadherin beta-8 (PCDH-beta-8) (Q91XZ2)
Organism: Mus musculus (Mouse)
Function: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (Probable). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location: Cell membrane {ECO:0000305|PubMed:27161523}; Single-pass type I membrane protein {ECO:0000305|PubMed:27161523}.
Interaction partners:
- Protocadherin beta-6
- Protocadherin beta 11
- Protocadherin beta 10
- Protocadherin beta 4
- Protocadherin beta 9
- Protocadherin beta 3
- Protocadherin beta 12
Sequence:
METALTKTPEKRQVIFLAILLLLWEASSEAISYSMPEETESGYLVANLAQDLGLRVGELTTRGARIHHNGNKELLQLDAERGNLLLKEKPDREALCGATEPCVLHFQIILENPVQFFQTDLQFTDINDHFPEFPDTEMLLKIQEIAQPGTVFPLKAAQDPDIGSNAVQNYTVSPNLHFHVVTLSRSDDRKYPELVLDRALDREEQPELTLILTALDGGAPPKSGTTTVRIEVVDINDNAPQFLQSLYAVEVPENSPLNALVVTVSARDLDAGIHGNVAYSLFQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGGLSGKCTVAIQVLDVNDNAPKLTISSLTSSIPENAPEAVVAVFSVSDPDSGDNGRMVCSIQNGLPFLLKPTFKNFYTLVTERPLDRESNAEYNITITVSDLGTPRLTTQHTITVQVSDINDNAPAFTQTSYTLFVHENNSPALHIGTISATDSDSGSNGLIIYSLLPPHDQQLGLASLISINSDNGQLFALRALDYEALQAFEFHVGATDRGSPALSSEALVRVVVLDDNDNAPFVLYPLQNASAPCTELLPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDAPKHRLLLLVKDNGEPLRSASVMLQVLVVDGFSQPYLPLPEVALNPTQEEDMLTLYLVIALASVSSLFLLSVLLFVGVKLCKKAREASLADCSIPEGHFPSHLVDVSGAGTLSQSYHYEVCLTEDSGTSDFKFMNPIIPSSLLQDS
Protein: Protein PCF11 (protein 1 of CF I) (P39081)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex. Independently involved in RNA polymerase II transcript termination. Binds RNA. Seems to bridge RNA polymerase II and the native transcript and may be involved in dismantling the RNA polymerase II elongation complex.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Pre-tRNA-processing protein PTA1
- mRNA cleavage and polyadenylation factor CLP1
- Cleavage factor two protein 2
- Endoribonuclease YSH1
- mRNA 3'-end-processing protein RNA15
- Protein CFT1
- mRNA 3'-end-processing protein RNA14
- Pre-mRNA polyadenylation factor FIP1
- Protein MPE1
Sequence:
MDHDTEVIVKDFNSILEELTFNSRPIITTLTKLAEENISCAQYFVDAIESRIEKCMPKQKLYAFYALDSICKNVGSPYTIYFSRNLFNLYKRTYLLVDNTTRTKLINMFKLWLNPNDTGLPLFEGSALEKIEQFLIKASALHQKNLQAMLPTPTVPLLLRDIDKLTCLTSERLKNQPNDEKLKMKLLVLSQLKQELKREKLTLNALKQVQMQLRQVFSQDQQVLQERMRYHELQQQQQQQQQQQQQQQQQQQQYHETKDMVGSYTQNSNSAIPLFGNNSDTTNQQNSLSSSLFGNISGVESFQEIEKKKSLNKINNLYASLKAEGLIYTPPKESIVTLYKKLNGHSNYSLDSHEKQLMKNLPKIPLLNDILSDCKAYFATVNIDVLNNPSLQLSEQTLLQENPIVQNNLIHLLYRSKPNKCSVCGKRFGNSESEKLLQNEHLDWHFRINTRIKGSQNTANTGISNSNLNTTTTRKNIQSRNWYLSDSQWAAFKDDEITSTKHKNDYTDPHANKNIDKSALNIHADENDEGSVDNTLGSDRSNELEIRGKYVVVPETSQDMAFKCPICKETVTGVYDEESGEWVWKNTIEVNGKYFHSTCYHETSQNSSKSNSGKVGLDDLKKLVTK
Protein: D-alanine--D-alanine ligase A (EC 6.3.2.4) (D-Ala-D-Ala ligase A) (D-alanylalanine synthetase A) (P0A6J8)
Organism: Escherichia coli (strain K12)
Function: Cell wall formation.
Subcellular location: Cytoplasm.
Interaction partners:
- UDP-N-acetylmuramate--L-alanine ligase
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- Alanine racemase, biosynthetic
- Alanine racemase, catabolic
- D-alanine--D-alanine ligase B
- UDP-N-acetylmuramoylalanine--D-glutamate ligase
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- Phospho-N-acetylmuramoyl-pentapeptide-transferase
- UDP-N-acetylenolpyruvoylglucosamine reductase
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
Sequence:
MEKLRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWHVSDASNYLLNADDPAHIALRPSATSLAQVPGKHEHQLIDAQNGQPLPTVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFITLTRANRHNISFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYAIAVDLAFEFDHKVIVEQGIKGREIECAVLGNDNPQASTCGEIVLTSDFYAYDTKYIDEDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINTLPGFTNISMYPKLWQASGLGYTDLITRLIELALERHAADNALKTTM
Protein: AP2-like ethylene-responsive transcription factor PLT1 (Protein AINTEGUMENTA-LIKE 3) (Protein PLETHORA 1) (Q5YGP8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Master regulator of basal/root fate. Essential for root quiescent center (QC) and columella specification, stem cell activity, as well as for establishment of the stem cell niche during embryogenesis. Modulates the root polar auxin transport by regulating the distribution of PIN genes. Essential role in respecifying pattern and polarity in damaged roots. Direct target of the transcriptional corepressor TPL. Expression levels and patterns regulated post-transcriptionally by root meristem growth factors (RGFs).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable polyol transporter 3
- TIC-like protein
- Protein TIME FOR COFFEE
Sequence:
MNSNNWLGFPLSPNNSSLPPHEYNLGLVSDHMDNPFQTQEWNMINPHGGGGDEGGEVPKVADFLGVSKPDENQSNHLVAYNDSDYYFHTNSLMPSVQSNDVVVAACDSNTPNNSSYHELQESAHNLQSLTLSMGTTAGNNVVDKASPSETTGDNASGGALAVVETATPRRALDTFGQRTSIYRGVTRHRWTGRYEAHLWDNSCRREGQSRKGRQVYLGGYDKEDKAARSYDLAALKYWGPSTTTNFPITNYEKEVEEMKHMTRQEFVAAIRRKSSGFSRGASMYRGVTRHHQHGRWQARIGRVAGNKDLYLGTFSTEEEAAEAYDIAAIKFRGLNAVTNFEINRYDVKAILESSTLPIGGGAAKRLKEAQALESSRKREAEMIALGSSFQYGGGSSTGSGSTSSRLQLQPYPLSIQQPLEPFLSLQNNDISHYNNNNAHDSSSFNHHSYIQTQLHLHQQTNNYLQQQSSQNSQQLYNAYLHSNPALLHGLVSTSIVDNNNNNGGSSGSYNTAAFLGNHGIGIGSSSTVGSTEEFPTVKTDYDMPSSDGTGGYSGWTSESVQGSNPGGVFTMWNE
Protein: Iron transporter SMF3 (Q12078)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has a role in controlling the cellular iron ion levels. Mobilizes vacuolar stores of iron in conditions of low iron levels.
Subcellular location: Vacuole membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Interaction partners:
- Iron transport multicopper oxidase FET5
- Iron transporter FTH1
- Protein CCC1
- Iron transport multicopper oxidase FET3
- Mitochondrial RNA-splicing protein MRS4
- Plasma membrane iron permease
- Iron-regulated transcriptional activator AFT2
- Iron-regulated transcriptional activator AFT1
- Ferric reductase transmembrane component 6
- mRNA decay factor CTH2
Sequence:
MRSYMQILQKFAKFIGPGILVSVAYMDPGNYATSVSGGAQYKYTLLFSIFISNIFAVLLQCLCVKLGTITGYDLAENCRHNLPKKLNYTLYLFAEVAIIATDLAEVVGTAIALQILFKIPLTWGVLLTVLDVLVILMFYTPNGQSLKKVRVFEFGVGILVIGTCICFVLELFKVSIPDKAELFKGFLPSNIIFKEQQALYISLGILGATVMPHSLYLGSSIVKPRLHDYDLKKYGKVNARPSLSAIKYTLNYAYAELIISLFLIATFVNSAILIVAGATLSGQPEAEDADLLSIYKLLVHYISPAAGLIFALAMLCSGQSAGIICTLAGQIVSEGFLQWSLPPWATRLCTRLIAIVPCLFVTLTMGEKGISDILNFSQVVLSLILPIVSAPLIYFTANRKLMVVHDENGVVRAPADVNAIADETTPLNSKHSKIVDFTNSRLLTYTSVFVWALIGSLNCYLVISYLLGADIHF
Protein: 2-hydroxyisoflavanone dehydratase (EC 3.1.1.1) (EC 4.2.1.105) (Carboxylesterase HIDM) (Q5NUF4)
Organism: Glycyrrhiza echinata (Licorice)
Function: Dehydratase that mediates the biosynthesis of isoflavonoids. Can better use 2,7-dihydroxy-4'-methoxyisoflavanone as substrate. Has also a slight carboxylesterase activity toward p-nitrophenyl butyrate.
Interaction partners:
Sequence:
MASSTSTTTSKEIDRELPPLLRVYKDGTVERFLGSSFVPPSPEDPETGVSTKDIVISENPTISARVYLPKLNNTTEKLPILVYYHGGAFCLESAFSFLHQRYLNIVASKANVLVVSIEYRLAPEHPLPAAYEDGWYALKWVTSHSTNNNKPTNADPWLIKHGDFNRFYIGGDTSGANIAHNAALRVGAEALPGGLRIAGVLSAFPLFWGSKPVLSEPVEGHEKSSPMQVWNFVYPDAPGGIDNPLINPLAPGAPNLATLGCPKMLVFVAGKDDLRDRGIWYYEAVKESGWKGDVELAQYEGEEHCFQIYHPETENSKDLIGRIASFLV
Protein: Calnexin (Q41798)
Organism: Zea mays (Maize)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Interaction partners:
Sequence:
YIKYIRPQDAGWDAKEFDNETPYTIMFGPDKCGSTNKVHFILKHKNPKTGKYVEHHLKFPPSVPYDKLSHVYTAILKPDNEVRILIDGEEKKKANFLSADDFEPALIPSKTIPDPDDKKPEDWDERAKIPDPDAVKPDDWDEDAPMEIVDEEATKPEGWLDDEPEEIDDPEAAKPEDWDDEEDGEWEAPKIDNPKCEEAPGCGEWKRPMKQNPAYKGKWHAPMIDNPNYKGIWKPQEIPNPEYFELDRPDFDPIAAIGIEIWTMQDGILFDNILIADDEKVATSILEKTWKPKYDVEKEKEKAEEAAAGADGLSDFQKKIFDVLYKIADIPFLAPYKTKIIDVIEKGEKQPNITIGILVSVVIVFVTVLFKILFGGXXXGGTCETCSXRAXVSPRPRRRTVLEAVVTRMRKRMKRTRQAHVGGPEEET
Protein: Cysteine protease XCP2 (EC 3.4.22.-) (Xylem cysteine peptidase 2) (AtXCP2) (Q9LM66)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cysteine protease involved in xylem tracheary element (TE) autolysis during xylogenesis in roots. Participates in micro autolysis within the intact central vacuole before mega autolysis is initiated by tonoplast implosion. Involved in susceptibility to the bacterial plant pathogen Ralstonia solanacearum.
Subcellular location: Vacuole {ECO:0000250|UniProtKB:O65493}. Cell membrane {ECO:0000250|UniProtKB:O65493}. Note=Predominantly vacuolar. May be associated to plasma membrane. {ECO:0000250|UniProtKB:O65493}.
Interaction partners:
- Protein TRACHEARY ELEMENT DIFFERENTIATION-RELATED 6
- UPF0235 protein At5g63440
- Pirin-like protein 2
- Subtilisin-like protease SBT4.14
- NAC domain-containing protein 30
- Cellulose synthase A catalytic subunit 8
- Metacaspase-9
- Transcription factor MYB46
- Protein TRACHEARY ELEMENT DIFFERENTIATION-RELATED 7
- Cellulose synthase A catalytic subunit 7
Sequence:
MALSSPSRILCFALALSAASLSLSFASSHDYSIVGYSPEDLESHDKLIELFENWISNFEKAYETVEEKFLRFEVFKDNLKHIDETNKKGKSYWLGLNEFADLSHEEFKKMYLGLKTDIVRRDEERSYAEFAYRDVEAVPKSVDWRKKGAVAEVKNQGSCGSCWAFSTVAAVEGINKIVTGNLTTLSEQELIDCDTTYNNGCNGGLMDYAFEYIVKNGGLRKEEDYPYSMEEGTCEMQKDESETVTINGHQDVPTNDEKSLLKALAHQPLSVAIDASGREFQFYSGGVFDGRCGVDLDHGVAAVGYGSSKGSDYIIVKNSWGPKWGEKGYIRLKRNTGKPEGLCGINKMASFPTKTK
Protein: N-alpha-acetyltransferase 60 (EC 2.3.1.259) (EC 2.3.1.48) (Q9LFD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- N-terminal acetyltransferase A complex auxiliary subunit NAA15
- N-terminal acetyltransferase A complex catalytic subunit NAA10
- DNA-binding enhancer protein-like protein
- Cell division cycle 5-like protein
- SAGA-associated factor 29 homolog B
- TATA box-binding protein-associated factor RNA polymerase I subunit B
- TATA box-binding protein associated factor RNA polymerase I subunit B-like protein
- TATA box-binding protein associated factor RNA polymerase I subunit B
- SAGA-associated factor 29 homolog A
- Histone acetyltransferase GCN5
Sequence:
MSRFPRGFVENSSMEEPKIARRPTICFRPINPSDLERLEQIHRDIFPIRYESEFFQNVVNGGDIVSWAAVDRSRPDGHSEELIGFVTAKIVLAKESEISDLIRYDSSKGEGTLVYILTLGVVETYRKRGIAKALINEVVKYSSGIPVCRGVYLHVIAHNNPAIRLYKRMSFRCVRRLHGFYLINGQHFDSYLFVYFINDGVIAESWLHCRDLAVLVLNYMRSGIKSFASKLTVNHDEKGSKWLKSKDNTRCLLPTQTKRNLASERVSSGYDYV
Protein: Solute carrier family 5 member 4A (SGLT3-a) (Q9ET37)
Organism: Mus musculus (Mouse)
Function: Has sugar-induced sodium-independent electrogenic activity. Generation of glucose-induced inward currents is pH-dependent, with activity in acidic conditions (pH 5) but not neutral conditions. Does not have sugar transport activity.
Subcellular location: Cell membrane {ECO:0000305|PubMed:22301059}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MASTASVSTSTASSELSSLSNNINNAADISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVEGDNLTINSRCYTPQPDSFHIFRDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSYGTGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRNSKEERIDLDAEDKEENGADDRTEEDQTEKPRGCLKKTCDLFCGLQRAEFKLTKVEEEALTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA
Protein: Polyprenal reductase (EC 1.3.1.94) (P40526)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9H8P0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dolichol kinase
- Dehydrodolichyl diphosphate synthase complex subunit NUS1
- Dehydrodolichyl diphosphate synthase complex subunit RER2
- Dehydrodolichyl diphosphate synthase complex subunit SRT1-farnesyl diphosphate specific))
- Very-long-chain enoyl-CoA reductase
- Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Sequence:
MYFDEEQLLKYTIYAYRLSFFVGICSLFIAKSCLPEFLQYGKTYRPKENSKYSSILERIKKFTVPKAYFSHFYYLATFLSLVTLYFYPKFPIVWIIFGHSLRRLYETLYVLHYTSNSRMNWSHYLVGIWFYSVLLLILNISLYKNSIPNTLNMNAFIIFCIASWDQYKNHVILANLVKYSLPTGRLFRLVCCPHYLDEIIIYSTLLPYEQEFYLTLVWVITSLTISALETKNYYRHKFKDNHVAPYAIIPFII
Protein: Ethylene-responsive transcription factor ERF060 (O65665)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Probable acyl-activating enzyme 17, peroxisomal
- E3 ubiquitin-protein ligase RMA2
- Mediator of RNA polymerase II transcription subunit 15a-like protein
- LOB domain-containing protein 38
- Monooxygenase 2
Sequence:
MAAIDMFNSNTDPFQEELMKALQPYTTNTDSSSPTYSNTVFGFNQTTSLGLNQLTPYQIHQIQNQLNQRRNIISPNLAPKPVPMKNMTAQKLYRGVRQRHWGKWVAEIRLPKNRTRLWLGTFDTAEEAAMAYDLAAYKLRGEFARLNFPQFRHEDGYYGGGSCFNPLHSSVDAKLQEICQSLRKTEDIDLPCSETELFPPKTEYQESEYGFLRSDENSFSDESHVESSSPESGITTFLDFSDSGFDEIGSFGLEKFPSVEIDWDAISKLSES
Protein: ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; PEN-20; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] (Q9QXU9)
Organism: Rattus norvegicus (Rat)
Function: May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9QXV0}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9QXV0}.
Interaction partners:
- G-protein coupled receptor 171
- Carboxypeptidase E
Sequence:
MAGSPLLCGPRAGGVGLLVLLLLGLLRLPPTLSARPVKEPRSLSAASAPLAETSTPLRLRRAVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQARVLAQLLRAWGSPRASDPPLAPDDDPDAPAAQLARALLRARLDPAALAAQLVPAPAPAAALRPRPPVYDDGPTGPDVEDAADETPDVDPELLRYLLGRILTGSSEPEAAPAPRRLRRAVDQDLGPEVPPENVLGALLRVKRLENSSPQAPARRLLPP
Protein: Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) (Q96HS1)
Organism: Homo sapiens (Human)
Function: Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:18387606}; Single-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:22915595, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:37498743}; Single-pass membrane protein {ECO:0000255}. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
Interaction partners:
- Kelch-like ECH-associated protein 1
- Bcl-2-like protein 1
- Dynamin-1-like protein
- Mixed lineage kinase domain-like protein
- FUN14 domain-containing protein 1
- Receptor-interacting serine/threonine-protein kinase 1
- Serine/threonine-protein kinase PINK1, mitochondrial
- Prohibitin-2
- Nuclear factor erythroid 2-related factor 2
- Presenilin-associated rhomboid-like protein, mitochondrial
Sequence:
MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDAEPRPAEPPAWAGGARPGPGVWDPNWDRREPLSLINVRKRNVESGEEELASKLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
Protein: Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like) (Q9H9P5)
Organism: Homo sapiens (Human)
Function: May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.
Subcellular location: [Isoform 4]: Cytoplasm. Nucleus. Note=Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm.
Interaction partners:
Sequence:
MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEATGVCPDGDECPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPGVLASQAMIEKILSEDPRWQDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGCQYCHSRTEQQFHPESTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEGGPRGSEQDSKQNHLAVFAAVHPPAPSVSSSVASSLASSAGSGSSSPTALPAPPARALPLGPASSTVEAVLGSALDLHLSNVNIASLEKDLEEQDGHDLGAAGPRSLAGSAPVAIPGSLPRAPSLHSPSSASTSPLGSLSQPLPGPVGSSAMTPPQQPPPLRSEPGTLGSAASSYSPLGLNGVPGSIWDFVSGSFSPSPSPILSAGPPSSSSASPNGAELARVRRQLDEAKRKIRQWEESWQQVKQVCDAWQREAQEAKERARVADSDRQLALQKKEEVEAQVIFQLRAKQCVACRERAHGAVLRPCQHHILCEPCAATAPECPYCKGQPLQW
Protein: Glutamate dehydrogenase (EC 1.4.1.3) (Q70PJ5)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
KVMVIPDMYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKQGGPIPVVPTADFQARVAGASEKDIVHSGLAYTMERSARQIMRTANKYNLGLDLRTAAYVNAIEKVFKVYNEAGITVT
Protein: Serine hydroxymethyltransferase (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Glycosylation-related protein 1) (Maternal effect lethal protein 32) (Serine methylase) (P50432)
Organism: Caenorhabditis elegans
Function: Interconversion of serine and glycine.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Aminomethyltransferase
- Probable methylenetetrahydrofolate reductase
- Bifunctional purine biosynthesis protein ATIC
- formate--tetrahydrofolate ligase
- Glycine cleavage system P protein
- C-1-tetrahydrofolate synthase, cytoplasmic
- Putative dihydrofolate reductase
- Alanine--glyoxylate aminotransferase
- Glycine cleavage system H protein
Sequence:
MFARIVSRRAATGLFAGASSQCKMADRQVHTPLAKVQRHKYTNNENILVDHVEKVDPEVFDIMKNEKKRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYGGNEFIDQMELLCQKRALEVFGLDPAKWGVNVQPLSGSPANFAVYTAIVGSNGRIMGLDLPDGGHLTHGFFTPARKVSATSEFFQSLPYKVDPTTGLIDYDKLEQNAMLFRPKAIIAGVSCYARHLDYERFRKIATKAGAYLMSDMAHISGLVAAGLIPSPFEYSDVVTTTTHKSLRGPRGALIFYRKGVRSTNAKGVDTLYDLEEKINSAVFPGLQGGPHNHTIAGIAVALRQCLSEDFVQYGEQVLKNAKTLAERMKKHGYALATGGTDNHLLLVDLRPIGVEGARAEHVLDLAHIACNKNTCPGDVSALRPGGIRLGTPALTSRGFQEQDFEKVGDFIHEGVQIAKKYNAEAGKTLKDFKSFTETNEPFKKDVADLAKRVEEFSTKFEIPGNETF