wanglab/gogpt-training-data huggingface dataset:
Protein: Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) (P14314)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000305|PubMed:10929008}.
Interaction partners:
- Neutral alpha-glucosidase AB
- Translocation protein SEC63 homolog
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Calreticulin
- Calnexin
- Polycystin-2
- Myristoylated alanine-rich C-kinase substrate
- Endoplasmin
- Protein disulfide-isomerase
- Polycystin-1
Sequence:
MLLPLLLLLPMCWAVEVKRPRGVSLTNHHFYDESKPFTCLDGSATIPFDQVNDDYCDCKDGSDEPGTAACPNGSFHCTNTGYKPLYIPSNRVNDGVCDCCDGTDEYNSGVICENTCKEKGRKERESLQQMAEVTREGFRLKKILIEDWKKAREEKQKKLIELQAGKKSLEDQVEMLRTVKEEAEKPEREAKEQHQKLWEEQLAAAKAQQEQELAADAFKELDDDMDGTVSVTELQTHPELDTDGDGALSEAEAQALLSGDTQTDATSFYDRVWAAIRDKYRSEALPTDLPAPSAPDLTEPKEEQPPVPSSPTEEEEEEEEEEEEEAEEEEEEEDSEEAPPPLSPPQPASPAEEDKMPPYDEQTQAFIDAAQEARNKFEEAERSLKDMEESIRNLEQEISFDFGPNGEFAYLYSQCYELTTNEYVYRLCPFKLVSQKPKLGGSPTSLGTWGSWIGPDHDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKETMVTSTTEPSRCEYLMELMTPAACPEPPPEAPTEDDHDEL
Protein: Leucine-rich repeat protein (LRRP) (Q38AE6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSGSRLDARGEKITTFWGIKDQGYDYVSIDLRDNCLQNFEHFGTHPKLLELRLENNMIESFMGLTRQPSLLVIDLEGNPIAAHPLHRVMVLLAVGFSVTTIDGVPVTTQEYDTARAMGYHAALAVSYGWKLEVGVRSQEEYLQIIEACKKARRKSPAQRGTFKTIDHALEERRESVIIRVPPNQTSVENSQCFSTMEYERMTERVKHLEELLYEAKKELKSQQQQQQQHKVDDVEMSRTDSLSAAELRCAHSILFTENIRLTTNVTTSTHEESSGCVQGALMFERASLVFLTFMSRTRLAEFPLCDLQVELHQNVLRIRGNHGSITDVFFGDTRTLRCVHKLIYLRRGCDVPLIFISSEAPENAKLLVDASVNTERGYFVGDNGPNDSFYPERGHGGSSIHANGSLMPYMNSFHYETAASAAGEDKQLPEVTQSALTLTLQDGQTPNTSLIQQSFANTYADIASEREATDETDDKDRSEVSQETLFSTNAVTPRLFSGSPQAVPIDENAFGPDIGAASADNREVAHTEAPAVSTPRDRGPPAVRVLRRQSSVFATQQPTSSRMKANTRTRVTSQTQVSVVSNSLEKDSSVLQDSCTLSLTDAATGVTMLSRPPPGAANSLSSSQLLVSAASDNGRSLVPIVEELVEGNPSVADPPAPSSSTPHVDNRLTPRVLVSRASTSGGRRSPAVRELRQRPLTTADHAPVVRLEVNAGESPVLQDHVPGAPTTTENGTVAPNVEPSGQGATTVEHLNAANVSTVHTSESVAPQQLASRAPTPGGRPPPPLRVPSRYSSVMAGQSPLPNRLSSAAGPRTAPQVPTTRASVPVGRSSPPARVRYKSPTTASGGLASTVHPSEVNGGESPVLQDHVPGAPTTTENETVAPNVEPSGQGATTVEHLNAANVSTVHTSESVAPQQLASRAPTPGGRPPPPLRVPSRYSSVMAGQSPLPNRLSSAAGPRTAPQVPTTRASVPVGRSSPPARVLYRCSPTDAAAAAKAPVPLQQGKSASGAFVGPMPMSSRASTSVERASSTAPILHRSSASGIASDALFAHAPPSTDGTSCQSCSPVATSRRSILSARGSSSTRLSRRWRPTATGDVVAFNHRGAALEGRVASRGSTSMVLGPAARTSSAMRFSRRRPPTAAGTGGSSTGTPQREDMCNPKNSLTAKSERLAGDPSFLSSSVDYKKFLNEPEPDSDTDVSLERLL
Protein: N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (Peptidoglycan recognition protein 2) (Q1W1Y3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAGICMQSSAVHLRNMEHFITAVAHLEHLNPQLSSLALVSNLCQIADQTHNVTHGFMRSSNNETETHPKIKERLNINLNLSHFFSQALHHFITAAYEEKGVVLTPDGTTVALAPLLLGLESGLRAENVSSQPNGFYLHPLARTLGLSFLNSTPTVRLGAEGCWDSVSAPMVFTLSNFPSLVTDAVVHGGMDGAILGKHLSVVNCSKMNVSTLLRSYYLRTVEELDDVLDPHLKGRNRRQNFQKITSSSLLQEKVAGVLPSQGDAELESLIAKGIKEFVLRYMDCPSIIPRCIWGAAPPQVPLELLSPPMSFLYIHHTAIPSKPCLNLQTCSQNMRAMQRFHQKDWGWYDIGYSFVVGSDGYIYEGRGWMSQGAHTKGRNNVGYGVAFIGDYSGRLPSTHDMELVRHHLVKCGVNNGFLQEDFTILGHRQVVVTTSCPGNALYSEITTWMHYKDKDPLK
Protein: Ubiquitin carboxyl-terminal hydrolase 17-like protein E (USP17-E) (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 2) (Deubiquitinating protein 3) (DUB-3) (Deubiquitinating protein 6) (Ubiquitin carboxyl-terminal hydrolase 17-like protein 2) (Ubiquitin thioesterase 17-like protein 2) (Ubiquitin-specific-processing protease 17-like protein 2) (Q7M764)
Organism: Mus musculus (Mouse)
Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
Subcellular location: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Interaction partners:
- CAAX prenyl protease 2
- Sin3 histone deacetylase corepressor complex component SDS3
- M-phase inducer phosphatase 1
- Ubiquitin carboxyl-terminal hydrolase 17-like protein B
Sequence:
MVVSLSFPEETGGENLPSAPLEDSSKFFEEVFGDMVFARSFPEADPALSSPDAPELHQDEAQVVEELTTNGKHSLSWESPQGPGCGLQNTGNSCYLNAALQCLTHTPPLADYMLSQEHSQTCCSPEGCKMCAMEAHVTQSLLHSHSGDVMKPSQILTSAFHKHQQEDAHEFLMFTLETMHESCLQVHRQSDPTPQDTSPIHDIFGGWWRSQIKCLHCQGTSHTFDPFLDVPLDISSAQSVNQALWDTGKSEELLGENAYYCGRCRQKMPASKTLHVHIAPKVLLLVLKRFSAFTGNKLDRKVSYPEFLDLKPYLSEPTGGPLPYALYAVLVHDGATSNSGHYFCCVKAGHGKWYKMDDTKVTRCDVTSVLNENAYVLFYVQQTDLKQVSIDMPEGRVHEVLDPKYQLKKSRRKKRKKQCHCTDDAGEACENREKRAKKETSLGEGKVPQEVNHEKAGQKHGNTKLVPQEQNHQRAGQNLRNTEVELDLPVDAIVIHQPRSTANWGTDAPDKENQPWHNGDRLLTSQGLMSPGQLCSQGGR
Protein: Olfactomedin-like protein 2A (Photomedin-1) (Q8BHP7)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000269|PubMed:15836428}.
Interaction partners:
Sequence:
MEAAAVLPRYLQLRLLLVLLLLVLLRAGPVWPDSKVFSDLDQVRMTSEGSDCRCKCIMRPLSKDACSRVRSGRARVEDFYTVETVSSGADCRCSCTAPPSSLNPCENEWKMEKLKKQAPELLKLQSMVDLLEGALYSMDLMKVHAYIQKVASQMNTLEESIKANLSLENKVVKDSVHHLSEQLKSYENQSAIMMSIKKELSSLGLQLLQRDAAAVPATAPASSPDSKAQDTAGGQGRDLNKYGSIQKSFSDKGLAKPPKEKLLKVEKLRKESIKGRIPQPTARPRALAQQQAVIRGFTYYKAGRQEARQEARQEAPKAAADSTLKGTSWLEKLPPKIEAKLPEPNSAKHDDVRLQASEGGNLTPDITTTTTSTSSSTTTTTGTTSTTSTTSTTSTTTPSPITTPWPTEPPLHPEVPSQGREDSCEGTLRAVDPPVKHHSYGRHEGAWMKDPAALDDRIYVTNYYYGNSLVEFRNLENFKQGRWSNMYKLPYNWIGTGHVVYQGAFYYNRAFTKNIIKYDLRQRFVASWALLPDVVYEDTTPWKWRGHSDIDFAVDESGLWVIYPAVDEHDETQHEVIVLSRLDPADLSVHRETTWKTRLRRNSYGNCFLVCGILYTVDTYNQHEGQVAYAFDTHTGTDAHPQLPFLNEYSYTTQVDYNPKERVLYAWDNGHQLTYTLHFVV
Protein: Secreted protein CSS2 (Condition specific secretion protein 2) (P43600)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Secreted {ECO:0000269|PubMed:26928762}.
Interaction partners:
- Secreted protein CSS3
Sequence:
MWCYSHFLLIFVSFVTSFAHKLPANNSTTNGGTDGIAVPVIETTIDSGMYSENGTDLMTPEDLPDLLSDGIVLSFANTTETGSDSDSTLIDSEDLRRCIDMPDRSCSAQRGNLCSYSFWDIPFSFLNTVHDIFGMTNMGNCAVMAGDKGAFYYKYYPVEPNCNSTIHQKTIDDALQQATEQLNGDFNNMYFFHVNRGGLWQGDMMVGTRVFTWFAGAKWAEHKGSIEAGFTS
Protein: Solute carrier family 34 member 2a (Type II Na/Pi cotransport system protein) (Q9PTQ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}.
Interaction partners:
Sequence:
MAPRPKHEHESDEKQPETLDGARKKSLSMAPAVSTAALIEDDPWEMMELQDTGVKWADLDTKKKVLRVFTTAAKLIMLLGLLYMFVCSLDVLSSAFQLVGGKAAGDIFQENKVLSNPLAGLVIGMLVTLLVQSSSTSSSIVVSMVSSGMLEVATAVPIIMGTNIGTSVTNTLVAIAQVGDRNKFRRAFAGATVHDFFNWLSVLVLLPLEVASGYLEKVTSLIVRSFNIESGEKAPALLNVITDPLTHSIIQLDESVMSGIAVGDPEARNKSLIKVWCHTASNTTVQNVTTTNCTDLCWELKNVTEIINIKKCSHIFVNTSLSDLAVGLILLAGSLLILCTCLICIVKLLNSMLKGQVAVVIKKIVNTDFPFPFAWLTGYIAILVGAGMTFIVQSSSVFTSAITPLVGIGVISIERAYPLSLGSNIGTTTTAILAAMASPGETLGNSLQIALVHFFFNLSGILLWYPIPITRIPIRLAKGLGETTAQYRWFAAFYIILCFFGLPLLVFGLSMAGWQVLMGVLVPIAVILIFAIIVNILQKHKPQWLPSALRSWDFLPLWAHSLDPWDRVVTVIAARCCCCCKCCNSNEEDEKAKLENLANGIEINDNTMTTVEIIEPKKTVDSCEILKATSL
Protein: CYC2-like cyclin, putative (Q389J6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein artemis
Sequence:
MTLSVDTAIGDTAICMERSCDAPTPTYAVKTRAMVLSGGSGCTLSRCRRLGRSARQRSPSNKRFSGRMSAASVTPSGGPVMDRSGTGYVDVCRGGECAPMLCRSGGCDHGVSIFAAAATPAAAVPLLDGTVAAECTNGAGGMPADGSRCVTQLYDAGASLRNESGRRYRNNYSCHYSNSGGSGYCCCSASYRGQKGHKGGQSQVFHNSPLFMGNGGNLPPNRGVISNYHYHHHPPCGASHHHHQRCAVRSHRRRGFGAAAVEAIRSRFQAGATMSHHAPPLSAVKCNRQTKQTASNGDQEPRQAFQVPLPRSKAAAGVTQPSATSCDAGVVRPSKGDFRIEMDTPFSATDSMNDPVNGSSRLSGIAPLFDLAIQQLILECDRRVANASGTACASAHSPSNSCNSQKQSSAHFSVNTHSFDMPTASHTKTTFAQTPKESSFATFAVEQAPLEGGQLESPHRDAEAEVMARDGACTTKLHRVEPRLEERVTARRENHVGNVVGRLFRDQSEDAVDLGSDCSKLQLLIVSVGLTVSFGESAPLVLIGTLIYLFRIVKRCDSEYSSVTAANWYRLTAVALLVATKMYVDGSGSWNECFSNATDIPLKELNKLEIDFLFLLDFDALITEEEVEARADWMDSVASRHDMMTPLRTFVLGSSCAPSCVATPLSPAADEAFRSVPLGSSSNMPSTPLSLTPSNMTPVNCFSTPFTQSRPIRNQCVGSLVSGVDASDKQQQQTRPSSMRRLSSSLCPCDRMSPLPLSVSSLSLTERLFSVVHAPAEPETPPSLRRFARQDDEPVSPLTPPDQERMSPVFFFCNATRGRRCNAMTAVGEKTNKTSPAGSAVQYRVSAGVAGDAWNGDEMDEEGGTPPHPRRCILSPPTQEAAPLPPLGMTDFHHRLPRK
Protein: MORN repeat-containing protein 5 (Q5VZ52)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9DAI9}.
Interaction partners:
- MORN repeat-containing protein 3
- Tektin-1
- Cilia- and flagella-associated protein 95
Sequence:
MEYTGSKYIGEYVDGRMEGKAKYILPTETIYVGEMKDGMFHGEGTLYFPSGSQYDAIWENGLAIKGTYTFSDGLHYDEKNWHYCDGYDRRFYTEILNGLKPAGMAQLTNMDPPRKIPKGYYDCGDGFYNPVTRVVKDYRNRFLRNADDDEHEWITRTCRKG
Protein: Methyl-accepting chemotaxis protein PctA (G3XD24)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids, except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE), chloroform and methylthiocyanate. Also mediates chemotaxis to histamine, but does not bind histamine. In addition, binds the quorum-sensing signal autoinducer 2 (AI-2), thus inducing chemotaxis toward AI-2 and biofilm formation.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Chemotaxis protein methyltransferase 1
- Chemotaxis protein CheA
- Chemotaxis protein CheA
- Chemotaxis protein methyltransferase 2
- Probable purine-binding chemotaxis protein
- Probable chemotaxis protein
- Probable chemoreceptor glutamine deamidase CheD
- Protein-glutamate methylesterase/protein-glutamine glutaminase 2
- Chemotaxis protein CheW
- Chemotaxis protein CheA
Sequence:
MIKSLKFSHKILLAASLVVFAAFALFTLYNDYLQRNAIREDLESYLREMGDVTSSNIQNWLGGRLLLVEQTAQTLARDHSPETVSALLEQPALTSTFSFTYLGQQDGVFTMRPDSPMPAGYDPRSRPWYKDAVAAGGLTLTEPYVDAATQELIITAATPVKAAGNTLGVVGGDLSLKTLVQIINSLDFSGMGYAFLVSGDGKILVHPDKEQVMKTLSEVYPQNTPKIATGFSEAELHGHTRILAFTPIKGLPSVTWYLALSIDKDKAYAMLSKFRVSAIAAALISIVAILVLLGLLIRLLMQPLHLMGRAMQDIAQGEGDLTKRLAVTSRDEFGVLGDAFNQFVERIHRSIREVAGTAHKLHDVSQLVVNASNSSMANSDEQSNRTNSVAAAINELGAAAQEIARNAADASHHASDANHQAEDGKQVVEQTIRAMNELSEKISASCANIEALNSRTVNIGQILEVIKGISEQTNLLALNAAIEAARAGEAGRGFAVVADEVRNLAHRAQESAQQIQKMIEELQVGAREAVATMTESQRYSLESVEIANRAGESLSSVTRRIGEIDGMNQSVATATEEQTAVVDSLNMDITEINTLNQEGVENLQATLRACGELETQAGRLRQLVDSFKI
Protein: Trypanosoma glutamic acid/alanine-rich protein domain-containing protein (Q57U18)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
Sequence:
MTARFLCLLAILTYVTADSIIEEGSQNTVSHVSAACLFSEALHGIPFGVKALKALAAANVSDASKAREGCQDAVRRAEDAFSSTPKVEEAVGRARAALKEAESAENAAKTALSDVEQYAARAPLLAAGKTAPVDDYLKSVAEDNSAASTARRIARGCSLPNRGVNSWVLKKAVEFGCEFFTGDICKILTDGMADLRAEYDQLEAAVRRASEARVAARAAESNAHKAAEEAERTAETEKADVQEISREEFEGNVEVPEDKEKTERTEVEEVPKKDPEGNVEVPEDKEKTERTEVEEVPKKDPEGNVEVPEDKEKTERTEVEEVPKKDPEGKVEISDDDHVQELGDDEGEEAEVGNDGSYAESIGGYTLLILLAALSHSAAAHF
Protein: Zinc finger and BTB domain containing 38 (D6RBC4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFLEDLTDRNFSNSPGPYVFCITEKGVVKEEKNEKRHEEPAITNGPRITNAFSIIETENSNNMFSPLDLRASFKKVSDSMRTASLCLERTDVCHEAEPVRTLAEHSYAVSSVAEAYRSQPVREHDGSSPGNTGKENCEALAAKPKTCRKPKTFSIPQDSDSATENIPPPPVSNLEVNQERSPQPAAVLTRSKSPNNEGDVHFSREDENQSSDVPGPPAAEVPPLVYNCSCCSKAFDSSTLLSAHMQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQICMRSSHMPIPGGNQRFLENYPTIGQNGGSFTGPEPLLSENRIGEFSSTGSTLPDTDHMVKFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPSVYPYKLYRLLPMKCKRAPYKSYRNSSYENARENSQMNESAPGTYVVQNPHSSELPTLNFQDTVNTLTNSPAIPLETSACQDIPTSANVQNAEGTKWGEEALKMDLDNNFYSTEVSVSSTENAVSSDLRAGDVPVLSLSNSSENAASVISYSGSAPSVIVHSSQFSSVIMHSNAIAAMTSSNHRAFSDPAVSQSLKDDSKPEPDKVGRFASRP
Protein: Uncharacterized protein (Q3UTR9)
Organism: Mus musculus (Mouse)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
DQLSKQQSEGDSVIKKLKEELAGEKQRTHQLEDDKMNIIKELTVQKEKLTHSEQALSDLQLTKQKLEDKVEDLVDQLSKSEKNNFDIQKENHELREHIRQNEEELSTVRSELTQSQTQGSSRNVKDDLLKERETQVQNLKQNLSEVEQLNEHLEQVAFDLRTENEELLEAYEEVRNQLEESVAGNKQISLEKTAMLEWEKAPLETELCRAEKRVLEEERKYEQTVQELSSACSPDTSALQLEQERLIQLNQEKDFEIAELKKSIEQMDTDHKRTKETLSSSLEEQKQLTQLINEKEICIVKLKEKSSELQKELDKCAQTLRKNETLRQTIEEKDRSLGSMKEENNHLQEELERLREQQSRVVPAPEPRTLDSTTELESELSQLHRIKGHLEEEIKHHQKMIEDQNQSKLQLLQSLQEQKKELDEFKYQHEQMSISHTRLFLEKDEEIKNL
Protein: ADP-ribosylation factor 6 (EC 3.6.5.2) (P26990)
Organism: Gallus gallus (Chicken)
Function: GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62330}. Cell membrane {ECO:0000250|UniProtKB:P62331}; Lipid-anchor {ECO:0000250|UniProtKB:P62330}. Endosome membrane {ECO:0000250|UniProtKB:P62331}; Lipid-anchor {ECO:0000250|UniProtKB:P62330}. Recycling endosome membrane {ECO:0000250|UniProtKB:P62331}; Lipid-anchor {ECO:0000250|UniProtKB:P62331}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:P62331}; Lipid-anchor {ECO:0000250|UniProtKB:P62331}. Cell projection, ruffle {ECO:0000250|UniProtKB:P62330}. Cleavage furrow {ECO:0000250|UniProtKB:P62330}. Midbody, Midbody ring {ECO:0000250|UniProtKB:P62331}. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body. After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles. Myristoylation is required for proper localization to membranes (By similarity). {ECO:0000250|UniProtKB:P62330, ECO:0000250|UniProtKB:P62331}.
Interaction partners:
- Uncharacterized protein.
- Cytohesin 3
- Uncharacterized protein.
- Kinesin-like protein
- Uncharacterized protein.
- ADP-ribosylation factor
- RAB interacting factor.
- Actin, cytoplasmic 1
- RAB11 family interacting protein 3.
- IQ motif and Sec7 domain 3.
Sequence:
MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATTGDGLYEGLTWLTSNYKS
Protein: mRNA-binding translational activator (Q59YJ9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Ribosome assembly factor mrt4
- UDP-N-acetylglucosamine diphosphorylase
- Nop13p
- ATP-dependent RNA helicase
Sequence:
MAAVYPRTCYKCGEVGHVADDCQQEERLCYNCHKPGHESNDCPDPKQNTAKQCYSCGDVGHIQTECPNQAQGAKCYNCGQFGHISKNCDSAPSSTNNAPSFKRPSGRASGTTCYKCGGPNHFARDCQANTVKCYACGKVGHISKDCHSSAGGSNFSAKTCYNCGKSGHISKECTA
Protein: Protein Wnt (Q3L257)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
Sequence:
SAGVVFAITRACSQGELKSCSCDPEKKGSAKDSKGRFDWGGCSDNIDYGVKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWKKYNGAIQVVMNQDGTGFTVANKRFKKPTKNDLVYFESSPDYCIRDRDVGSPGTAGRVCNQTSRGMDSCEVMCCGRGYDTLRVSRMTKCECKFHWCCAVRCQDCLEEVDIHTCKAPKAAGWASRT
Protein: Myb-related transcription factor, partner of profilin (Myb-related protein p42POP) (Partner of profilin) (Q86VE0)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MASAAAGEAEETTRLRKPRFSFEENQILIREVRAHYPQLYGAQSRRVSVAERRRVWDGIAAKINGITSWKRTGQEVQKRWNDFKRRTKEKLARVPHSTQGAGPAAEDAFSAEEETIFAILGPGVAAPGAGAGAEEPPAAPSSQPPPPSACPQRYVLSEDRREDRRADTSAHSKAGSSSPEPWARPSCTPQEGGCPRPKERESPPPSALQPVQLPRLALSPPPPAPPLPPPPPLAQVAPSPPSPPPPPRPPPTLSASDPSLDFLRAQQETANAIRELAGTLRQGLAKLSEALSALLPLLPGTPVDSLPPPLPPPPPPPPPPRPVLPPPAPKVEITPEPVSVVAAVVDGAVVAARGVIIAPRSEEGAPRPPPAPLPPHDSPPHKRRKGFPTRKRRGRWKSP
Protein: Meiotic mRNA stability protein kinase SSN3 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin-dependent kinase 8) (Suppressor of RNA polymerase B SRB10) (P39073)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair may also positively and negatively regulate numerous transcriptional activators in response to changes in nutritional and physiological conditions. Phosphorylates GCN4, promoting its ubiquitin-mediated degradation, and MSN2, promoting its nuclear exclusion. Phosphorylates STE12, thereby promoting its degradation and inhibition of filamentous growth. Phosphorylates GAL4, and this phosphorylation is required for efficient galactose-inducible transcription. Also phosphorylates BDF1 and the TAF2 subunit of the TFIID complex.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 12
- Mediator of RNA polymerase II transcription subunit 13
- RNA polymerase II holoenzyme cyclin-like subunit
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 17
- General negative regulator of transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 21
- DNA-directed RNA polymerase II subunit RPB1
- Mediator of RNA polymerase II transcription subunit 2
Sequence:
MYNGKDRAQNSYQPMYQRPMQVQGQQQAQSFVGKKNTIGSVHGKAPMLMANNDVFTIGPYRARKDRMRVSVLEKYEVIGYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNALRRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKKPLTVFYAIKKFKTEKDGVEQLHYTGISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRDNLATWYHSAGGRDKHALSLLYHLLNYDPIKRIDAFNALEHKYFTESDIPVSENVFEGLTYKYPARRIHTNDNDIMNLGSRTKNNTQASGITAGAAANALGGLGVNRRILAAAAAAAAAVSGNNASDEPSRKKNRR
Protein: Chorismate mutase 1, chloroplastic (AtCM1) (EC 5.4.99.5) (CM-1) (P42738)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in chloroplast biogenesis.
Subcellular location: Plastid, chloroplast {ECO:0000305|PubMed:22223895}.
Interaction partners:
- Chorismate synthase, chloroplastic
- Arogenate dehydratase/prephenate dehydratase 1, chloroplastic
- Arogenate dehydratase/prephenate dehydratase 2, chloroplastic
- Arogenate dehydratase/prephenate dehydratase 6, chloroplastic
- Arogenate dehydratase 5, chloroplastic
- Arogenate dehydratase 4, chloroplastic
- Arogenate dehydratase 3, chloroplastic
- Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
- Arogenate dehydrogenase 1, chloroplastic
- Shikimate kinase 2, chloroplastic
Sequence:
MEASLLMRSSCCSSAIGGFFDHRRELSTSTPISTLLPLPSTKSSFSVRCSLPQPSKPRSGTSSVHAVMTLAGSLTGKKRVDESESLTLEGIRNSLIRQEDSIIFGLLERAKYCYNADTYDPTAFDMDGFNGSLVEYMVKGTEKLHAKVGRFKSPDEHPFFPDDLPEPMLPPLQYPKVLHFAADSININKKIWNMYFRDLVPRLVKKGDDGNYGSTAVCDAICLQCLSKRIHYGKFVAEAKFQASPEAYESAIKAQDKDALMDMLTFPTVEDAIKKRVEMKTRTYGQEVKVGMEEKEEEEEEGNESHVYKISPILVGDLYGDWIMPLTKEVQVEYLLRRLD
Protein: Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) (Q9GZN2)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Subcellular location: Nucleus. Note=Excluded from nucleoli.
Interaction partners:
- Mothers against decapentaplegic homolog 3
- Mothers against decapentaplegic homolog 2
- Homeobox protein TGIF1
- Transforming growth factor-beta-induced protein ig-h3
- Histone deacetylase 1
- Polyadenylate-binding protein 5
Sequence:
MSDSDLGEDEGLLSLAGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGKASDVALPRGSSPSVLAVSVPAPTNVLSLSVCSMPLHSGQGEKPAAPFPRGELESPKPLVTPGSTLTLLTRAEAGSPTGGLFNTPPPTPPEQDKEDFSSFQLLVEVALQRAAEMELQKQQDPSLPLLHTPIPLVSENPQ
Protein: Cholesterol 7-desaturase nvd (EC 1.14.19.21) (Neverland) (Nvd_Dm) (Rieske-domain protein Neverland) (Q1JUZ1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. Essential regulator of steroid biosynthesis, as this reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid. Required for insect molting, metamorphosis and body growth throughout development via the regulation of ecdysteroid biosynthesis in the prothoracic gland.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Spookier
- Cytochrome P450 307a1
- Short-chain dehydrogenase/reductase)
- Cytochrome P450 302a1, mitochondrial
- Ecdysone 20-monooxygenase
- Cytochrome P450 315a1, mitochondrial
- Cytochrome P450 306a1
- Probable cytochrome P450 6t3
- Glutathione S-transferase E14
- Cytochrome P450 18a1
Sequence:
MTSYSLFWMSLLKNNWKPISNDFVICLWTLAVTFIRIYWIFFVPLEWKKDLDNEKWSFLRKTENVVCYNHKRDTINRLRKLKIQKIIELPPPYPNGWYGILKSSQLKAGEATCVSCLGEDLVIFRSKKDIVFILDAYCPHLGANLGIGGSVADDCVICPFHQWKFRGTDGLCINIPYSTSVPKGSKLKKWISQEVDGFIFIWYHAEQTELPWDLPVPMGEIDDTFVYHGHNEFYINCHIQEIPENGADIAHFNAIHKKNFINGSWAQKKRLFGLGSHHWKARWSPFTGKLKYLAEVNLSHTFKLFGKFGCFRMEVSGKQIGPSIVCLEVNSYTFGKIKVFQYITPIEPMLQKVVHEFYGPRWIAPLMKIFIYGESLMFERDIKIWNHKVFNRNPILAKEDASIKKFRLWFSQFYSSNSKIYSEATNIGW
Protein: E3 ubiquitin-protein ligase (EC 2.3.2.26) (A0A590UJQ1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSDSGSQLGSMGSLTMKSQLQITETRFHHLDQAGLELLTSGSTHLGLPKYRDYRREPPRPAFISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE