wanglab/gogpt-training-data huggingface dataset:
Protein: Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Q6RY07)
Organism: Rattus norvegicus (Rat)
Function: Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}.
Interaction partners:
- Beta-hexosaminidase subunit alpha
- Chitotriosidase-1
- Chitinase acidic-like 1
- N-acetyl-D-glucosamine kinase
- N-acylglucosamine 2-epimerase
- Transcriptional repressor CTCF
- Arginase-1
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
Sequence:
MAKLILVTGLVLLLNVQLGSAYNLVCYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNQITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKELREAFEQEAIESNRPRLMVTAAVAAGISNIQAGYEIPELSQYLDFIHVMTYDLHGSWDGYTGENSPLYKLPTETGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPEYGHTYILSNPSDTGIGAPTSGNGPAGPYTRQAGFWAYYEICTFLRNGATQDWDAPQEVPYAYKGNEWVGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALDIPTAGCTAPDLPSEPVTTPPGSGSGGGSSGGGSEGSGFCAGKADGLYPVADDRNAFWHCINGITYQQHCQAGLVFDTSCNCCNWP
Protein: Chitinase 4 (EC 3.2.1.14) (OsChia2b) (Pathogenesis related (PR)-3 chitinase 4) (O04138)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydrolyzes chitin and may function in reproductive organs during embryogenesis and seed maturation.
Interaction partners:
- Beta-hexosaminidase
- Beta-hexosaminidase
- Beta-hexosaminidase
- Os05g0390200 protein.
- Beta-hexosaminidase.
- Beta-hexosaminidase
Sequence:
MAAKMATMVALVFGLALLLSAAAPAAAQNCGCQDGYCCSQWGYCGTTEAYCGQGCQSGPCWGSGGEAAAGMAGRKAGAGAGVSVESVVTEAFFNGIKNQAPNGCAGKSFYTRQSFLNAARSYSGFANDRTNDDSKREIAAFFAHVTHETGHMCYINEINGANMDYCDKSNKQWPCQPGKKYYGRGPLQISWNFNYGPAGKNIGFDGLRDPDKVAQDPTISFKTALWFWMNNVHQVMSQGFGATIRAINGALECNGKNPGAVNARVNYYKDYCRQFGVSPGGNLYC
Protein: Lithostathine-2 (Islet of Langerhans regenerating protein 2) (REG-2) (Pancreatic stone protein 2) (PSP) (Pancreatic thread protein 2) (PTP) (Q08731)
Organism: Mus musculus (Mouse)
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Chymotrypsin-like elastase family member 3B
- Anionic trypsin-2
- Chymotrypsin-like elastase family member 2A
Sequence:
MAQNNVYLILFLCLMFLSYSQGQVAEEDFPLAEKDLPSAKINCPEGANAYGSYCYYLIEDRLTWGEADLFCQNMNAGHLVSILSQAESNFVASLVKESGTTASNVWTGLHDPKSNRRWHWSSGSLFLFKSWATGAPSTANRGYCVSLTSNTAYKKWKDENCEAQYSFVCKFRA
Protein: Voltage-dependent calcium channel gamma-1 subunit (Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma) (P97707)
Organism: Rattus norvegicus (Rat)
Function: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P19518}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19518}.
Interaction partners:
- Voltage-dependent L-type calcium channel subunit beta-1
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Voltage-dependent calcium channel subunit alpha-2/delta-1
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Voltage-dependent calcium channel subunit alpha-2/delta-2
- Voltage-dependent calcium channel gamma-4 subunit
- Voltage-dependent calcium channel gamma-7 subunit
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Voltage-dependent L-type calcium channel subunit beta-4
- Voltage-dependent N-type calcium channel subunit alpha-1B
Sequence:
MSQTKTAKVRVTLFFILAGGVLAMVAVVTDHWAVLSPHLEHHNETCVAAHFGLWRICTTWVAMHNQDKNCDGTIPAGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIIIGSICAFLSFGNKRDYLLRPASMFYAFAGLCLIVSVEVMRQSVKRMIDSEDTVWIEYYYSWSFACACAGFTLLFLGGLFLLLFSLPRMPQNPWESCMDTESEH
Protein: CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) (Q9UDT6)
Organism: Homo sapiens (Human)
Function: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O55156}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Z0H8}. Note=Localizes preferentially to the ends of tyrosinated microtubules. {ECO:0000250|UniProtKB:Q9Z0H8}.
Interaction partners:
- CLK4-associating serine/arginine rich protein
- CLIP-associating protein 2
- CLIP-associating protein 1
- General transcription factor II-I repeat domain-containing protein 1
- LIM domain kinase 1
- Transducin beta-like protein 2
- Eukaryotic translation initiation factor 4H
- Microtubule-associated protein RP/EB family member 3
- Microtubule-associated protein RP/EB family member 1
- General transcription factor II-I
Sequence:
MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDRSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDKH
Protein: Nuclear receptor subfamily 1 group I member 2 (Nuclear receptor subfamily 1, group I, member 2, isoform CRA_a) (J3KPQ3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
LEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
Protein: NAD-dependent epimerase/dehydratase family protein (Q72EM3)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS15
Sequence:
MSSFRACVLGASGFLGSHLVHHLLKAGCQVHAFSRDSRRNPLLTDELMSSCSIFTGDFFNTQDVERALADCDVCFHLVSTTIPKTSNDDPLRDVRENLSGSLTLLECVRRTGVRKVVYASSGGAIYGKHLMPRISENHPTDPLCSYGIVKLAVEKYLALYHELYGIDYAALRISNPFGPLQRTSAEQGVIGVFLGKILRNEPLHVWGDGSVVRDYIYVEDVARALVLAARLNTEHHVFNIGSGAGLSLNDIIDMMRSVTGRDVVVKYDQNRVFDVPYSVLDVSLAERELGWRALFPFKVGVSLAWVWLCENS
Protein: Testisin (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP-1) (Serine protease 21) (Q9Y6M0)
Organism: Homo sapiens (Human)
Function: Could regulate proteolytic events associated with testicular germ cell maturation.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
Sequence:
MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLLFFPLLWALPLLGPV
Protein: Serotonin receptor 5-HT2 subtype (Q24511)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MEMQSYSGRGPSTGTSETATATAAVASASASDTAATFTLRHFNCRLEEADWPGPRQPFIDCEGSHTNSTSYTPSSLPTSKNLIEGPNNTFQCARQAIDEAEHNAFYSCDGESPLSENCTLRLKARLLRWPYEAYEHIRLAINGALSDYASDKLSDSSSCDEGGMVLQCKLGQAHELLLCHLQQLEREPLREVGSAEESFSNDSLLQAFQIELGAERDGLWSFLNLSELMEPDHGFLGIMNVTNTSLDMFLPNLTALNTTSTASTADMATEFAVTKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFIGLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKSIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESEPFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGILRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNCKR
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (A0A2R8Y7F3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
HAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED
Protein: Nitrate reductase [NADH] 1 (NR) (EC 1.7.1.1) (P17571)
Organism: Zea mays (Maize)
Function: Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
Interaction partners:
- Nitrate reductase
- Ferredoxin--nitrite reductase, chloroplastic
- Ferredoxin--nitrite reductase, chloroplastic
- Nitrate transport2
- High affinity nitrate transporter 2.5
- Nitrate transport1
- High affinity nitrate transporter 2.7
- Nitrate transport3
- dihydropyrimidine dehydrogenase
- Dihydroorotate dehydrogenase
Sequence:
GFPVRVIIPGCIGGRMVKWLKRIIVTPAESDNYYHFKDNRVLPSHVDAELANAEAWWYKPEYIINELNINSVITTPCHDEILPINAFTTQRPYTLKGYAYSGGGKKVTRVEVTLDGGETWLVCTDHPEKPTKYGKYWCWCFWSLEVEVLDLLSAKEIAVRAWDESLNTQPEKLIWNVMGMMNNCWFRVKTNVCKPHKGEIGIVFDHPTLPGNESGGWMAKEKHLETAEAAAPGLKRSTSTPFMNTTDVGKEFTMSEVRKHASQESAWIVVHGHVYDCTKFLKDHPGGADSILINAGTDCTEEFDAIHSDKAKALLDTYRIGELITTGTGYSSDNSVHGGSVLSHLAPIRRAVRAPALSNPREKIHCRLVGKKELSRDVRLFRFSLPSPDQVLGLPIGKHIFVCASIEGKLCMRAYTPTSMVDEIGHFDLLVKVYFKNEHPKFPNGGLMTQYLDSLPVGSYIDVKGPLGHVEYTGRGSFVINGKQRHASRLAMICGGSGITPMYQIIQAVLRDQPEDHTEMHLVYANRTEDDILLRDELDRWAAEYPDRLKVWYVIDQVKRPEEGWKYSVGFVTEAVLREHVPEGGDDTLALACGPPPMIQFAISPNLEKMKYDMANSFVVF
Protein: Putative pyridoxal kinase C18.10 (EC 2.7.1.35) (O74860)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Probable pyridoxamine 5'-phosphate oxidase
- Putative pyridoxal kinase C6F6.11c
- Uncharacterized glutaminase C222.08c
- Uncharacterized oxidoreductase C215.11c
- Uncharacterized oxidoreductase C3A11.11c
- Pyridoxal reductase
- Probable pyridoxal reductase 2
- Probable pyridoxal 5'-phosphate synthase subunit PDX1
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
Sequence:
MTFPNVKFIGNKRVLSIQSSVSHGYVGNRSATFPLQLHEWEVDVVPTVHFSNHLGYGATRGSACIPEEVHDLLNALLQDNGIVYDAILTGFVPNHDIIQVIFDCVLAYKKDHPKVLWLLDPVMGDQGKMYVDTNVISTYKAMIPHAFAITPNAFEVEILTDIVIHTQMDAKRGLEKIYQLYGIQNAIITSFEVEESPGTLFCMGYSCEHGKPQLFLYQFPSLSGVFTGTGDLFSGLLLAKYREELDKRKHQQSDETKQTKRPTVLACAVGQVLSCMHTVLVNTKTYADEILLEDPKIASDEFLLSNARELRLIQSRTALLSKKSIYEAEFLPGFEEGEDV
Protein: ARM repeat superfamily protein (Q93VS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Histone H4
- Transportin-1
- ARM repeat superfamily protein
- GMP synthase
- At3g08910
- DNAJ heat shock family protein
- DNAJ heat shock family protein
- DNAJ heat shock family protein
- DNAJ heat shock family protein
- DNAJ heat shock family protein
Sequence:
MASEANQLQQAQLAMVLGSDSAPFETLISHLMSSSNEQRSSAESLFNLAKQSNPDTLSLKLAHLLQLSPHPEGRAMAAVLLRKLLTRDDAYLWPRLSLSTQSSLKSSMLYCIQHEEAKSISKKICDTVSELASGILPENGWPELLPFVFQCVTSVTPKLQESAFLILAQLSQYVGETLTPHIKELHGVFLQCLSSNSASSDVKIAALNAVISFVQCLANSTERDRFQDVLPAMIRTLTESLNNGNEATAQEALELLIELAGTEPRFLRRQLVDIVGSMLQIAEADSLEESTRHLAIEFLVTLAEARERAPGMVRKLPQFIDRLFAVLMKMLEDIEDDPAWYSAETEDEDAGETSNYSMGQECLDRLAISLGGNTIVPVAYQQFSAYLAASEWQKHHASLIALAQIAEGCSKVMIKNLDQVVSMVLSQFQSPHPRVRWAAINAIGQLSTDLGPDLQNQHHERVLPALAAAMDDFQNPRVQAHAASAVLNFSENCTPEILSPYLDGVVSKLLVLLQNGKQMVQEGALTALASVADSSQEHFQKYYDTVMPYLKTILMNATDKSKRMLRAKSMECISLVGMAVGKDRFKEDARQVMEVLMSLQGSQMEADDPITSYMLQAWARLCKCLGQDFLPYMKVVMPPLLQSAQLKPDVTITSADSEDEAEDSDDESMETIILGDKRIGIKTSVLEEKATACNMLCCYADELKEGFFPWIDQVAPTLVPLLKFYFHEEVRRAAVSAMPELMRSAKLAIEKGESQGRDLSYLKQLSDYIIPAMLEALHKEPDTEICVSMLEAINECLQISGNLLDEGKIRSIVDEIKQVMTASSSRKRERGERAHAEDFDAEEGELIKEENEQEEEIFDQVGEILGTLVKTFKASFLPFFDELSSYLTPMWGRDKTAEERRIAICIFDDVAEQCREAAFKYYDTYLPFVLEACNDESPEVRQAAVYGLGVCAEFGGSVFKPLIGEALSRLNVVIQLPNARQSENAMAYDNAVSAVGKICQFHRDSIDSSQVLPAWLNCLPISNDVLEAKVVHDQLCSMVERQDVDLLGPNNQHLPKILIVFAEVLTGKDVVTQETAGRMINILRQLQQTLPPSALASTWSTLKPEQQLALQSMLSS
Protein: Error-prone DNA polymerase 1 (EC 2.7.7.7) (Q92LA6)
Organism: Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Function: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
Interaction partners:
Sequence:
MSADAVFCELGARTNFSFLEGAAPAEEMVVFAKKAGLAGLGIADRNSVAGVVRAHAKAKVEGYPFQPGARLVFADGTPDILAYPKNRRGWGHLCRLLSAGNLRSKKGDCTLHLADLLEWQEELLLIVMQGEGRPEPESLEVLLGTLKEHAGNRLYLGLAPHYDGFDRHDFAVLAAIARKAGIGLLATNDALYHDPHYRPLADVVTSIREHVPIAGAGFLLQKNAERHLKGPREMARLFSDYPEAIANTRKFFRELAFSLDELSHQYPDENADGETPAESLRRLVAEGAAERYPEGVPEKVMRQIDYELELIHDKKYEPYFLTVHKLVKFARSVNILCQGRGSAANSSVCFCLGITDVDPQKFTLLFDRFLSKDRDEPPDIDVDFEHERREEVIQYIYRTYGKEHAGLTAAVISYRSRSAGREVAKAFGLSEDVQSALVSSIWGWGTSPFTEEQAKGAGLDAADPLTRRVLAYASLLMNFPRHLSQHVGGFVITRDRLDEVVPIMNTAMPDRYMIEWDKDDLDELKILKVDVLALGMLTCLAKGFKLLEAHYGEPITLAEIYQDHRDAVYDMICRADTVGVFQIESRAQMSMLPRLQPREMYDLVIEVAIVRPGPIQGNMVHPYLKRREAQRRGEAVVYPSPELKAVLERTLGVPLFQEQAMQIAITAAGFSPSEADRLRRAMATFKRTGTIHTFERKMVEGMVANDYEREFAERCFNQIKGFGEYGFPESHAASFASLVYASAWLKTYYPDIFCAALLNAQPMGFYAPAQLVRDAREHGVRMLPVDINHSDWDALLEGEGAFDKNAVHPRHASMREVIKTRKAVRLGFRLVKGLKQTDMKALVARRGEGYRSVHDLWLRSGLSRSVLERLADADAFRSIGLDRRAALWAVKALDEQSAVERLPLFEGAGSDDLQIEPKVALPDMPAGEQVIHDYRTLTLSLKAHPVSFMREDFSRRGILRSRDLAATATGRWVTVAGLVLVRQRPGSANGVIFMTIEDETGIANIIVWEKTFQKYRRQVMGSRLVKVRGRLQNQSGVIHVVADHLEDITPMLGLLRREARRFGVNDRADGALRPSADAREKKKLRQLRLGLPARAAPEGEAAAQVAEVMPKGRNFH
Protein: PDZ-RhoGEF (Rho guanine nucleotide exchange factor 11) (Q49U75)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MNVRHPTSTLDRLSSLTLGDSERRSSPGQQRETLPDLSSDNTGTGLVQRCVVVQRDNLGFGFTVCGERIKLVQNVRPGGAAVKAGVQEGDRIIKVNGSMVSSMSHQEVVKMIKSGTYVALTLQGPPPSVASTPLQPLPSDLLSNHRTAPGEAPPLPQTPPTGSSTPTQRITGPKPLQDPEVQKHATEILRKMLEQEEAELQNLLEEQSRNPSVSLEERIERAKRRASQVRVKIQQDVDGTRSDAVANYLTAGEGRLSIDSSEGDVEVCESPFSSPSSFLRNPLIHRQTSDTHTSDSGKMQIIGPEEEEEDDGYTINEMDGPFQDIELLKSRPAHMTVFMRYVFGQLLDPNPLLFYLSVEAYLGSSPKDARSLAPQICSHFLDHDAPLKIKVREEFLTDIENRLHAQEDIRGPLSELQQQVLPDIQDQLQDYRNKQTMGLGSLFGESDLQQLDGDPVKEKQVVDKQIVALWEILSKHEEDRSSPLASAVHLYLRHSGIKLRDSKVFPGLMSEKEKWLPFFPKAKKLSSAKRERDGEDKKRNPILKYIGKPRSTSQSTFHVPLSPTEVRPGSVRNIIQQFESNSDSLEDGELEGQRLSGSFGEDSMESPTISVRLARSESLKAQGEGRRRGGGTGAEFVPRSRSDVDMEDCEEREGPGLRPLHHSASSSASSSSARSLENPTPPYTPRSQRRIVEVPVSLLPDAPALDEDVIDSHNWQDTVEPHILASLTSREIDRQAVIYELFTTEVSHLRTLRVLDQVFYQKMQSVLSPEELSCIFLNLRQVYELHASLCESMKKCRESVIVQGIGDIMLARFEGEAGDQFEEQVSHLCSQQSPALELIKNKQRKDPRFAHLIQECEASPHCRRLQLKDLLVSEMQRLTKYPLLLDNIIKYTETSSPDLPLLRRAQACCRGILQEVNEDVRETEHRHLLSQYQRRLDATPLERLANPVAAQFRNLDLTTKRMVHEGPLTWRVGKDKAIEIQALLLSDLLLLLQRGPDDRLILRCPSRSLGGVTDLKTPFCPVVCLDSCLVRPVATDNKALYVISTSERQIYELVAGTLLEKNTWKDQLEKTISAAAQGGSTKPNTPRFRSPGAGVRLSADQSEGSESRMYPDREDEMVLSPVVTPADAAEECPDEDPDPGQKNKAGVAESALQDVETLRQLIFRDLEDGWSQDSDDTPTNETANERSPFTDRPGNESSDPAPSESSSQWEEEPVEAPPLEVLQPAVQVVRKAVGVGCSLPDDITDDVTASQSSEDGGNLFYLVMSTDQVVSDESTTDELKDLHHSVFSSSFINEEEEQDTPCLSPTDQSLIESQGHRPGLSQSQSSVQRHVIKNVDEIFNTMEELMKKLQHLRDIEADHHKLLKKLRKPLPVDKMSSDGVHKSPTAARLSSLDRGAGDGKEGVSTEPAQPQIQSTGF
Protein: Transmembrane protein 91 (Dispanin subfamily C member 3) (DSPC3) (Q6ZNR0)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MDSPSLRELQQPLLEGTECETPAQKPGRHELGSPLREIAFAESLRGLQFLSPPLPSVSAGLGEPRPPDVEDMSSSDSDSDWDGGSRLSPFLPHDHLGLAVFSMLCCFWPVGIAAFCLAQKTNKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALVTLAAYLASRDPP
Protein: Protein PBN1 (Protease B non-derepressible protein 1) (P25580)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Aids the autocatalytic processing of PRB1. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9649520}; Single-pass type III membrane protein {ECO:0000269|PubMed:9649520}.
Interaction partners:
- GPI mannosyltransferase 1
- GPI mannosyltransferase 3
- GPI mannosyltransferase 2
- GPI-anchored wall transfer protein 1
- Dol-P-Man:Man
- Dolichol-phosphate mannosyltransferase
- 27S pre-rRNA
Sequence:
MVTRHRVTVLYNAPEDIGNHMRQNDTHLTVRGGSGVVLQQRWLLERTGSLDKSFTRITWRPRADLARSLSVIENELSAGFSVYSNSSDVPERFITNPVYNSFHSEKFDIEQYLPPEVDLNLSWNPEDFTYDISVEPTQIQIVEYRLLKQGEEFTIARVKDEKLEVGVFFVDASDESDVDIGGIRCNWRMDDGKMERCQKTSLLYKQGHIAYNHSTTTTSLYLNEPIGLHPKIMIDLTDFEERPKCMYLMHLQLPLELFIDKFQSSPLLLFGEDDLELPEYSLRDKAWGSESIFELKAGTMNEVTLHTRYIEPSNNKGDKLEVSFDPEVILACDTGDNKVSRNPFYKKGLGYESLFTDDTTFRHLNSTTLLVPIPRPDTKDYSKIKNGTLLCLLISIIYIFSKVFGNNKKKRSVKRE
Protein: Interactor protein for cytohesin exchange factors 1 (Q80VL0)
Organism: Rattus norvegicus (Rat)
Function: Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12920129}. Cell membrane {ECO:0000269|PubMed:12920129}. Note=Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation.
Interaction partners:
- Connector enhancer of kinase suppressor of ras 3
- Cytohesin-2
- Cytohesin-1
- Cytohesin 4
- Cytohesin-3
Sequence:
MSRRRISCKDLGHADCQGWLYKKKEKGTFLSNKWKKFWVVLKGSSLYWYGNQLAEKADGFVNLPDFTVERASECKKKNAFKINHPQIKTFYFAAENLQEMNMWLNKLGFAVTHKESTTKDEECYSESEQEDPETAVEAPPPPSASATSSPVAARRASSSSPKRRETSCSFSSLENTVKAPSRFSSSGSKERQSWLDIVNSSPATEDVGHPLSFAVQVHTLASSEASSCRVSENSSTTPESGCLNSLSSDDTSSLNNSQDHLTVPDRASGSRMTDRDEIKSSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQVPQDPEVTPQEIMNPTSSDCVENSL
Protein: S-adenosyl-L-methionine-dependent methyltransferase (EC 2.1.1.-) (O33293)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MARNPAAQTAFGPMVLAAVEQNEPPGRRLVDDDLADLFLPRPLRWLAGATRSAVLRRLLISASEWSGRGLWANLACRKRFIGDKLDEALGDIDAVVILGAGLDTRAYRLTRRVRMPVFEVDLPVNIARKAKTVRRVLGELPLSVRLVALDFEHDDLLTALAEHGYRTEYRVFFVCEGVTQYLTERAVRRTLEGLRAAAPGSRMVFTYVRRDFIDGTNRYGTRTLYHTVRQRRQLWHFGLDPEEVAGFLADYGWRLTEQAGPEELVQRYVEPTGRNLNASQIEWSAYAEKSEPVTPR
Protein: Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] (P18850)
Organism: Homo sapiens (Human)
Function: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12782636}; Single-pass type II membrane protein {ECO:0000255}. Note=Translocates from the endoplasmic reticulum to the Golgi, where it is processed. {ECO:0000269|PubMed:12782636}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (PubMed:10564271, PubMed:12782636). THBS4 promotes its nuclear shuttling (By similarity). {ECO:0000250|UniProtKB:F6VAN0, ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
- X-box-binding protein 1
- Vesicle-associated membrane protein-associated protein B/C
- DNA damage-inducible transcript 3 protein
- Endoplasmin
- Membrane-bound transcription factor site-2 protease
- Eukaryotic translation initiation factor 2-alpha kinase 3
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Membrane-bound transcription factor site-1 protease
- Wolframin
Sequence:
MGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAANETYENNFDNLDFDLDLMPWESDIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKTENGLTPKKKIQVNSKPSIQPKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTVVQLQAPGVLPSAQPVLAVAGGVTQLPNHVVNVVPAPSANSPVNGKLSVTKPVLQSTMRNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYGPMSMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATHVVSTIPESLQ