wanglab/gogpt-training-data huggingface dataset:
Protein: Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A) (Q9P2J2)
Organism: Homo sapiens (Human)
Function: Functions in dendrite outgrowth and synapse maturation.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Note=Enriched at the excitatory synapses in mature neurons. {ECO:0000250}.
Interaction partners:
Sequence:
MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL
Protein: Transcription factor MYB73 (Myb-related protein 73) (AtMYB73) (O23160)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that functions in salt stress response. Acts as negative regulator of NHX7/SOS1 and CBL4/SOS3 induction in response to salt stress. In response to auxin, activates the transcription of the auxin-responsive gene IAA19. The IAA19 transcription activation by MYB73 is enhanced by direct interaction between MYB73 and PYL8.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:23809151}.
Interaction partners:
- Abscisic acid receptor PYL8
Sequence:
MSNPTRKNMERIKGPWSPEEDDLLQRLVQKHGPRNWSLISKSIPGRSGKSCRLRWCNQLSPEVEHRAFSQEEDETIIRAHARFGNKWATISRLLNGRTDNAIKNHWNSTLKRKCSVEGQSCDFGGNGGYDGNLGEEQPLKRTASGGGGVSTGLYMSPGSPSGSDVSEQSSGGAHVFKPTVRSEVTASSSGEDPPTYLSLSLPWTDETVRVNEPVQLNQNTVMDGGYTAELFPVRKEEQVEVEEEEAKGISGGFGGEFMTVVQEMIRTEVRSYMADLQRGNVGGSSSGGGGGGSCMPQSVNSRRVGFREFIVNQIGIGKME
Protein: Type IV secretion protein Dot (Q5ZWW6)
Organism: Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Interaction partners:
Sequence:
MSFIKVGIKMGGLTSEQYHSQVVGKIGYIARCMQTIDPENNLKKIREDYQDVLIWAEKNYRFEEILEASKSGKCPNDLDALSRRSLILQELLRLVSSISPFKMKLDLIESQYEKMKQHVNLWKSDYHVKLNQLNQLTDYLKNAAPTPKNNFLRAMTSVLQMQIAQYGITEDNEGINQLFKLGLHLLAMANEKIDEQYHLFKGYVKDQPEESPFEGILPAEDQKILVKTMIDYAMPKLSSKVLQDKLSALSSSDVLTKTLLDSIDRIVKENEKLNALSKVKLGKFGLDIREIEVIYSQALKISPQDALQYTAQQCDAQLLSMAFPDSQNYIIESISNKKVKTIAELIHSKEFIYQIIKTEVFKQVDPNEKIRLQAATELYQLLGRIMDKQINLFTKMNLEQINEYIQTKTKAILDKIPERVELLTFMGFEIPTFKGIETLMTDISHSQDNETLAIAQEFYTNIKNAKNQLLGDKLIEDITPQDVEKFFNQCSQYGSEAAEKLADNRPVLTKIADILTAIARWAISLIGFNTPPQFLAPTRTCVDQVSDEITKIKLKLEDTLGSLQKVQEESLSL
Protein: Alpha-farnesene synthase (EC 4.2.3.46) (Q84KL5)
Organism: Pinus taeda (Loblolly pine)
Function: Involved in sesquiterpene (C15) biosynthesis. The major product is alpha-farnesene.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MSSLAVDDAERRVGDYHPNLWDDALIQSLSTPYGASPYRDVAEKLIGEIKEMFASISIEDGDDEICYFLQRLWMIDNVERLGISRHFENEIKAAMEDVYSRHWSDKGIACGRHSVVADLNSTALAFRTLRLHGYSVCSDVFKIFQDQKGEFACSADQTEGEIKGILNLLRASLIAFPGERILQEAEIFATTYLKEALPKIQGSRLSQEIEYVLEYGWLTDLPRLETRNYIEVLAEEITPYFKKPCMAVEKLLKLAKIEFNLFHSLQQTELKHLSRWWKDSGFAQLTFTRHRHVEFYTLASCIAMEPKHSAFRLGFAKLCYLGIVLDDIYDTYGKMEELELFTAAIKRWDTSTTECLPEYMKGVYMAFYDCVNEMARQAEKTQGWDTLDYARKTWEALIDAFMEEAKWISSGYVPTFQKYLDNGKVSFGYRAATLQPILTLDIPLPLHILQEIDFPSSFNDLASSILRLRGDICGYQAERSRGEQASSISCYMKDNPGSTEEDALSHVNAMIGDKIPEFNWEFMKPSKAPISSKKYAFDILRAFYHLYKYRDGFSIAKIETKKLVMRTVLDPVPM
Protein: Cyclic nucleotide-binding domain-containing protein (Q581W9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein kinase A catalytic subunit
- Protein kinase A catalytic subunit isoform 2
- Protein kinase A catalytic subunit isoform 1
Sequence:
MWTVFAPDQNQLYALYMHRCGAHGVGKPSREMLALLTEDDKAWQSRVTEEAHQRGVKVEDLQEIEGDTVERQRERESVTPLAFHRVFRLTPFIANNERDGSAARIHVGARGLLAILDVVRELPFLEVLDLSNLTSLFLADTYQYDGVKGNDVISALCSIAATHPSLRVIDVRGQPLGTLAAHHFLELLKENTRIQEVHYDTDAVACHLVAAINKQQEKNAATPRQPPKLPQEPSDMIRRMPFLDRKTVKEQQLLRRLVESETGIGDVMSEEEVSTFVLYARTMSTTEVITRSRGLLGDGIHLFLLKSGVIRAAAEARGFEMRRGDFFGDTHGDILFSQNLLQEVERGVVYAIPIEHCGALRAVWARRVAAHYSTLKYNTLLQAVDVWTRLRTCCCSVSRVFEEGEEVIAKGDPFKGLFLVVSGVFSVIGCAGARVGGKEFTVGDAFGEEPLLTRRECSSVTIVAGKNESSGENCCLVVEGCAARILFNYLRPVLLTLVSAYSQHEELQPVQK
Protein: Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (Cytochrome P450-C21B) (P08686)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000269|PubMed:10198222}. Microsome membrane {ECO:0000269|PubMed:10198222}; Peripheral membrane protein {ECO:0000269|PubMed:10198222}.
Interaction partners:
- 11-beta-hydroxysteroid dehydrogenase type 2
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
- Cytochrome P450 11B2, mitochondrial
- Cytochrome P450 11B1, mitochondrial
- Cholesterol side-chain cleavage enzyme, mitochondrial
- 3-oxo-5-alpha-steroid 4-dehydrogenase 1
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- 11-beta-hydroxysteroid dehydrogenase 1
- Steroid 17-alpha-hydroxylase/17,20 lyase
Sequence:
MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQSQ
Protein: Choline transporter-like protein 2 (Solute carrier family 44 member 2) (Q8BY89)
Organism: Mus musculus (Mouse)
Function: Choline transporter.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8IWA5}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8IWA5}; Multi-pass membrane protein {ECO:0000255}. Note=Mainly expressed in mitochondria. {ECO:0000250|UniProtKB:B4F795}.
Interaction partners:
- Cochlin
Sequence:
MGKDSQNYYGKHGTPQKYDPTFKGPIYNRGCTDVICCVLLFLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNADKPFLFYFNIVKCANPLVLLEFHCPTPQICVKQCPDRYLTLLSARNTRDFDYYKQFCVPGFQNNKGVTEILRDGECPAVITPSKPLAQRCFPAIHASKGVLMVGNETTYEDGHGARKNITDLVEGAKKANKILEARQLAMQIFEDYTVSWYWIIIGLVIAMVLSLLFIVLLRFLAGIMVWVMIVMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDLRVYLHLRQTWMAFMIILSILEVVIILLLIFLRKRILIAIALIKEASRAVGHVMCSLLYPLVTFFLLCLCIAYWASTSVFLSTSNTAVYKVVDDTACPLLRKTCNPETFPLRNESLQCPTARCQFAFYGGESTYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWAMRKPDDMPAFPLFSAFGRALRYHTGSLAFGSLILAIVQIIRVMLEYLDQRLKAAQNKFAKFLMVCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIIGSYLIAHGFFSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNKTNKKVAES
Protein: Thioredoxin reductase 2, mitochondrial (mt-TR) (EC 1.8.1.9) (Thioredoxin reductase TR3) (Q9N2I8)
Organism: Bos taurus (Bovine)
Function: Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10447675}.
Interaction partners:
- Thioredoxin, mitochondrial
- Selenide, water dikinase 1
- Thioredoxin
- Selenocysteine lyase
- Thioredoxin
- Cystathionine gamma-lyase
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- thioredoxin-disulfide reductase
- Aminotran_1_2 domain-containing protein.
- Kynurenine--oxoglutarate transaminase 3
Sequence:
MAALRGAAARFRGRAPGGARGAAGRQCYDLLVIGGGSGGLACAKEAAQLGKKVAVLDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAPHYGWGVAQAPHSWATLADAVQNHVKSLNWGHRIQLQDRKVKYFNVKASFVDTHTVCGVSKGGEETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDLFWLKESPGKTLVVGASYVALECAGLLTGLGLDTTVMIRSVPLRAFDQQMASLVTEHMAGHGTRILRGCAPEKVEKLPGQQLRVTWVDLTSDRKDAGTFDTVLWAIGRVPETASLNLEKAGVHTNPVTGKILVDAQETTSVPHIYAIGDVAEGRPELTPTAIMAGRLLAQRLSGRTSDLMDYSSVPTTVFTPLEYGCVGLSEEAAVARHGEEHVEVYHAFYKPLEFTVPQRDASQCYIKMVCLREPPQLVLGLHFLGPNAGEVIQGFALGIKCGASYQQLMRTVGIHPTCAEEVAKLRISKRSGLDPTVTGCUG
Protein: J domain-containing protein (Q38A91)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVFDKELRNADNWRLYHLLELEPPVTAKQVQWLFRKVTLRHHFYQAYNILRDEERKSLYDSLGENFVGYLNSGSWGPLIQLLGAKATVAVCCGVWVLMILLMLFFFLAVGARADRLITWTWMQVAAPGLTVTLIVLIATAVAMAVSFFLRQPKEEGMRFVDRIPAIGNFVAAFFYCIFAFIGASTVDSYAPQRHNNYAPYFALPILADVIYYLSTMVWRWPRNRRLDLEVGMQESKPILWYAPCVFAGLHIILSIVQWVLLAQRVDRIIKISWYAAASPIAVRAVVRVAESCMTSLARRAIGIKSVLGVVFDTLGSLFFNGLLLCSVFFTAARFVRGRRVVPLILVFLPVYLVLFYLLFCTIYTLFYLLRRITENAREERMNNLKWTPVEPQAGDKVVPTLLRDFDASERIIWDDIDDESTMQYSTGYDEVTFETEGYDDYETGEEEEEEEEEELFARGAMVSGSSAPQTAPAHQRNVPLSRQESELVIDDDHSVVTIESSEEQPVRRHHAYHDPYESRTGTGLVGPQSETEYTQYDTNNDAYEVGDTNLESECASSDTSSSFEASGTAHSERHQDPPSENVRRN
Protein: Phenylcoumaran benzylic ether reductase 1 (AtPCBER1) (EC 1.23.1.-) (Q9T030)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Oxidoreductase involved in lignan biosynthesis. Catalyzes the NADPH-dependent reduction of phenylcoumaran benzylic ethers. Converts dehydrodiconiferyl alcohol (DDC) to isodihydrodehydrodiconiferyl alcohol (IDDDC), and dihydrodehydrodiconiferyl alcohol (DDDC) to tetrahydrodehydrodiconiferyl alcohol (TDDC). Plays an important role in the biosynthesis of secondary metabolites. In addition to the 8-5'-linked neolignan DDC, can reduce the 8-8'-linked lignans, pinoresinol, and lariciresinol, but with lower activities.
Interaction partners:
- Small ribosomal subunit protein uS19y
- Sugar transport protein 7
- Large ribosomal subunit protein uL11x
- Probable xyloglucan endotransglucosylase/hydrolase protein 8
- Large ribosomal subunit protein uL5z
- Fasciclin-like arabinogalactan protein 10
- UDP-glucuronate 4-epimerase 4
- Tubulin-folding cofactor E
- UDP-glucuronate 4-epimerase 1
Sequence:
MTSKSKILFIGGTGYIGKYIVEASARSGHPTLVLVRNSTLTSPSRSSTIENFKNLGVQFLLGDLDDHTSLVNSIKQADVVISTVGHSLLGHQYKIISAIKEAGNVKRFFPSEFGNDVDRVFTVEPAKSAYATKAKIRRTIEAEGIPYTYVSCNFFAGYFLPTLAQPGATSAPRDKVIVLGDGNPKAVFNKEEDIGTYTINAVDDPRTLNKILYIRPPMNTYSFNDLVSLWENKIGKTLERIYVPEEQLLKQIIESSPPLNVMLSLCHCVFVKGGHTSFEIEPSFGVEASELYPDVKYTTVDEILNQYV
Protein: Fibroblast growth factor 11 (FGF-11) (Fibroblast growth factor homologous factor 3) (FHF-3) (Q92914)
Organism: Homo sapiens (Human)
Function: Probably involved in nervous system development and function.
Interaction partners:
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor 1
- Fibroblast growth factor 17
Sequence:
MAALASSLIRQKREVREPGGSRPVSAQRRVCPRGTKSLCQKQLLILLSKVRLCGGRPARPDRGPEPQLKGIVTKLFCRQGFYLQANPDGSIQGTPEDTSSFTHFNLIPVGLRVVTIQSAKLGHYMAMNAEGLLYSSPHFTAECRFKECVFENYYVLYASALYRQRRSGRAWYLGLDKEGQVMKGNRVKKTKAAAHFLPKLLEVAMYQEPSLHSVPEASPSSPPAP
Protein: Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7) (Q92504)
Organism: Homo sapiens (Human)
Function: Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). Has an essential role in B cell development and is required for proper B cell receptor signaling.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14525538, ECO:0000269|PubMed:29980658, ECO:0000269|PubMed:30237509, ECO:0000269|PubMed:30718914}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:15705588}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Prefoldin subunit 6
- (3R)-3-hydroxyacyl-CoA dehydrogenase (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (KAR alpha subunit) (Estradiol 17-beta-dehydrogenase 8) (Protein Ke6) (Ke6) (Testosterone 17-beta-dehydrogenase 8)
- Small ribosomal subunit protein uS13
- Zinc transporter 6
- E3 ubiquitin-protein ligase CHIP
- Zinc transporter 7
- Kinesin-like protein KIFC1
- Proton-coupled zinc antiporter SLC30A5
- Zinc transporter ZIP9
- Zinc transporter ZIP1
Sequence:
MARGLGAPHWVAVGLLTWATLGLLVAGLGGHDDLHDDLQEDFHGHSHRHSHEDFHHGHSHAHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLYHRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGPVRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE
Protein: Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2) (O75908)
Organism: Homo sapiens (Human)
Function: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O88908}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Delta
- 7-dehydrocholesterol reductase
- Sterol O-acyltransferase 1
- Cytochrome P450 7A1
- Cholesterol 25-hydroxylase
- Sterol 26-hydroxylase, mitochondrial
- Vacuolar protein sorting-associated protein 52 homolog
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Cholesterol 24-hydroxylase
- Insulin-like growth factor-binding protein 6
Sequence:
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
Protein: Proteasome assembly chaperone 3 (Q57ZB5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEGPPPVCFRQCSFTYGAEPSTLHISQQCFSDYVWILVTEDDTCVPGVVLRFDPHDAGPCVGCESLNNLPSLPCEYLLGVRDHALTNILSSAIAHAIQSVGEQRPLLLCVSAAKTAKRLQTTEERMSFVRMVREKVVALAKGETC
Protein: Endoribonuclease MazF3 (EC 3.1.-.-) (23S rRNA endonuclease MazF3) (Toxin MazF3) (mRNA interferase MazF-mt6) (P9WIH9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Toxic component of a type II toxin-antitoxin (TA) system. Acts as an mRNA and 23S rRNA interferase, cleaving predominantly after the first 2 Us in the sequence 5'-UUCCU-3'; in 23S rRNA only cleaves once in the ribosomal A site in dissociated but not intact ribosomes. Cleavage of 23S rRNA inhibits protein translation; the 23S rRNA region cleaved is involved in tRNA-binding in the A site, 30S and 50S subunit interaction and ribosome recycling factor association. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. It dramatically increases persister cell formation in M.smegmatis upon challenge with gentamicin or kanamycin. Overexpression leads to bacteriostasis rather than bacteriocide. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE3.
Interaction partners:
- Antitoxin MazE3
- Endoribonuclease MazF6
- Endoribonuclease MazF4
- Endoribonuclease MazF9
- Probable endoribonuclease MazF5
- Antitoxin MazE6
- Toxin RelE
Sequence:
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNTQTIPVCDLGRQIGYLLASQEPALAEAIGNAFDLDWVVA
Protein: BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) (O15155)
Organism: Homo sapiens (Human)
Function: Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:34779586}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:34779586}. Golgi apparatus membrane {ECO:0000250}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). {ECO:0000250}.
Interaction partners:
- Syntaxin-5
- Sec1 family domain-containing protein 1
- Vesicle-trafficking protein SEC22b
- Golgi SNAP receptor complex member 1
- Golgi SNAP receptor complex member 2
- Synaptobrevin homolog YKT6
- Vesicle-associated membrane protein 8
- Vesicle-trafficking protein SEC22a
- Vesicle-associated membrane protein 7
- Vesicle-trafficking protein SEC22c
Sequence:
MRRAGLGEGVPPGNYGNYGYANSGYSACEEENERLTESLRSKVTAIKSLSIEIGHEVKTQNKLLAEMDSQFDSTTGFLGKTMGKLKILSRGSQTKLLCYMMLFSLFVFFIIYWIIKLR
Protein: T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (W3/25 antigen) (CD antigen CD4) (P05540)
Organism: Rattus norvegicus (Rat)
Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P01730}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01730}. Note=Localizes to lipid rafts. {ECO:0000250|UniProtKB:P01730}.
Interaction partners:
- Proto-oncogene tyrosine-protein kinase LCK
- C-C chemokine receptor type 5
- C-X-C chemokine receptor type 4
- T-cell surface glycoprotein CD8 alpha chain
- Tyrosine-protein kinase
- T-cell surface glycoprotein CD8 beta chain
- Forkhead box P3
- CD19 molecule
- Interleukin-10
- Interleukin-4
Sequence:
MCRGFSFRHLLPLLLLQLSKLLVVTQGKTVVLGKEGGSAELPCESTSRRSASFAWKSSDQKTILGYKNKLLIKGSLELYSRFDSRKNAWERGSFPLIINKLRMEDSQTYVCELENKKEEVELWVFRVTFNPGTRLLQGQSLTLILDSNPKVSDPPIECKHKSSNIVKDSKAFSTHSLRIQDSGIWNCTVTLNQKKHSFDMKLSVLGFASTSITAYKSEGESAEFSFPLNLGEESLQGELRWKAEKAPSSQSWITFSLKNQKVSVQKSTSNPKFQLSETLPLTLQIPQVSLQFAGSGNLTLTLDRGILYQEVNLVVMKVTQPDSNTLTCEVMGPTSPKMRLILKQENQEARVSRQEKVIQVQAPEAGVWQCLLSEGEEVKMDSKIQVLSKGLNQTMFLAVVLGSAFSFLVFTGLCILFCVRCRHQQRQAARMSQIKRLLSEKKTCQCSHRMQKSHNLI
Protein: BK channel (H7BRM5)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGEIYSPSQSKGFNQPYGYPMNCNLSRVFMEMTEEDRKCLEERKYWCFLLSSITTFCASMILVVIWRVVTHLCCQRREKEFVEPIPAPEAVQINMNGSKHAPSETDPFLKQQEEKHLGWMTEAKDWAGELISGQSLTGRFLVLLVFILSIGSLIIYFYDASFQNFQVETCIPWQDSPSQQIDLGFNIFFLVYFFIRFIAASDKVWFLLEMYSWIDFFTIPPSFVAIYLQRNWLGFRFLRALRLMTVPDILQYLNILKTSSSIRLTQLVTIFVAVCLTGAGLVHLLENSGDFFKGFINPHRITYADSVYFVLVTMSTVGYGDIYCTTLCGRLFMIFFILFGLAMFASYVPEIADLIGNRQKYGGEYKGEHGKKHIVVCGHITYDSVSHFLQDFLHEDRDDVDVEVVFLHRVVPDLELEGLFKRHFTKVEFFTGTVMDSLDLSRVKIGDADACLVLANKYSTNPDAEDAANIMRVISIKNYSSDIRVIVQLMQYHNKAYLLNIPSWDWKRGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSPHTPLWLNDYLRGAGMEMYTESLSPSFANMSFPEAANLLFNRLGLLLLAIELKDEENKECNIAINPGPHIVIQPQTQGFFIAQSADEVKRAFFWCKQCHDDIKDVSLIKKCKCKNLALFRRNTKHSTAARARATDVLQQFQPQAPAGPMGHLGQQVQLRMINQQRPSSGGRRNSMSIPPDGRGVDFSKDFEQQFQDMKYDSTGMFHWCPSRNLEDCVLERHQAAMTVLNGHVVVCLFADQDSPLIGLRNFIMPLRSSNFHYHELKHVVIVGDLEYLRKEWKTLYNLPKISILNGSPLSRADLRAVNINLCDMCVIISARVPNTEDTTLADKEAILASLNIKAMQFDDTLGFFPMRHQTGDRSPLGSPISMQKKGAKFGTNVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAISVLDSLMSTTYFNDSALTLIRTLVTGGATPELELILAEGAGLRGGYSTPETLSNRDRCRIAQISLQDNPYDGVVHNTTYGAMFTIALRRYGQLCIGLYRLHDQDNPDSMKRYVITNPPAELRIKNTDYVYVLEQFDPGLEYEPGKRHF
Protein: Ectonucleoside triphosphate diphosphohydrolase 5 (NTPDase 5) (EC 3.6.1.6) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (Uridine-diphosphatase ENTPD5) (UDPase ENTPD5) (Q6P6S9)
Organism: Rattus norvegicus (Rat)
Function: Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (By similarity). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9WUZ9}. Secreted {ECO:0000250|UniProtKB:O75356}.
Interaction partners:
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleoside triphosphate diphosphohydrolase 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- UMP-CMP kinase
- Ectonucleoside triphosphate diphosphohydrolase 1
- Ectonucleoside triphosphate diphosphohydrolase 8
- 5'-nucleotidase
- Inosine triphosphate pyrophosphatase
- AMP deaminase 3
- 5'-nucleotidase, cytosolic IA
Sequence:
MATSWASVFLLIIAYVGGTVFYREQQTWFEGVFLSSMCPVNVSAGTFYGIMFDAGSTGTRIHVYTFVQRTSGQLPFLEGEIFDSVKPGLSAFVDQPKQGAETVQELLEVAKDSIPRSHWKRTPVVLKATAGLRLLPEQKAQTLLLEVEEIFKNSPFLVPDDSVSIMDGSYEGILAWVTVNFLTGQLHGRGQETVGTLDLGGASTQITFLPQLEKTLEQTPKGYLASFEMFNSTFKLYTHSYLGFGLKAARLATLGALEAEGTDGHTFRSACLPRWLEAEWIFGGVKYQYGGNQEGEMGFEPCYAEVRRVVQGKLHQPEEIRGSSFYAFSYYYDRAAETHLIDYEKGGVLKVEDFERKAREVCDNLESFSSGSPFLCMDLSYITALLKDGFGFEDGTLLQLTKKVNNIETGWALGATFHLLQSLGITS