wanglab/gogpt-training-data huggingface dataset:
Protein: Ras-like protein rasG (EC 3.6.5.2) (P15064)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Ras guanine nucleotide exchange factor C
- Protein kinase 2
- Ras guanine nucleotide exchange factor A
- Neurofibromin-A
- Probable serine/threonine-protein kinase roco5
- Rac guanine nucleotide exchange factor B
- Uncharacterized protein
- Serine/threonine-protein kinase phg2
- Ras guanine nucleotide exchange factor R
- Ras GTPase-activating-like protein gapA
Sequence:
MTEYKLVIVGGGGVGKSALTIQLIQNHFIDEYDPTIEDSYRKQVTIDEETCLLDILDTAGQEEYSAMRDQYMRTGQGFLCVYSITSRSSFDEIASFREQILRVKDKDRVPMIVVGNKCDLESDRQVTTGEGQDLAKSFGSPFLETSAKIRVNVEEAFYSLVREIRKDLKGDSKPEKGKKKRPLKACTLL
Protein: Putative auxin response factor 14 (Q9LQE8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression.
Subcellular location: Nucleus.
Interaction partners:
- Auxin-responsive protein IAA34
- B3 domain-containing protein REM12
- Auxin-responsive protein IAA8
- Auxin-responsive protein IAA32
- Auxin-responsive protein IAA5
- Auxin-responsive protein IAA10
- Auxin-responsive protein IAA15
- B3 domain-containing protein REM17
- Auxin-responsive protein IAA11
- Mitotic spindle checkpoint protein MAD2
Sequence:
MESGNVVNTQPELSGIIDGSKSYMYEQLWKLCAGPLCDIPKLGEKVYYFPQGHIELVEASTREELNELQPICDFPSKLQCRVIAIQLKVENNSDETYAEITLMPDTTQVVIPTQNQNQFRPLVNSFTKVLTASDTSVHGGFSVPKKHAIECLPPLDMSQPLPTQEILAIDLHGNQWRFRHIYRGTAQRHLLTIGWNAFTTSKKLVEGDVIVFVRGETGELRVGIRRAGHQQGNIPSSIVSIESMRHGIIASAKHAFDNQCMFIVVYKPRSSQFIVSYDKFLDVVNNKFNVGSRFTMRFEGDDFSERRSFGTIIGVSDFSPHWKCSEWRSLEVQWDEFASFPRPNQVSPWDIEHLTPWSNVSRSSFLKNKRSREVNEIGSSSSHLLPPTLTQGQEIGQQSMATPMNISLRYRDITEDAMTPSRLLMSYPVQPMAKLNYNNVVTPIEENITTNAVASFRLFGVSLATPSVIKDPVEQIGLEISRLTQEKKFGQSQILRSPTEIQSKQFSSTRTCTKVQMQGVTIGRAVDLSVLNGYDQLILELEKLFDLKGQLQARNQWEIAFTNNEEDKMLVGEDPWPEFCNMVKKIFIYSKEEVKNLKSRKSLSS
Protein: Proteasome subunit alpha type (Q9FER4)
Organism: Zea mays (Maize)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Interaction partners:
Sequence:
MSRGTGAGYDRHITIFSPEGRLYQVEYAFKAVKSAGVTSIGVRGADSVCVVTQKKVPDKLLDQTSVTHLFPITKYVGLLATGLTADGRSLVSQARNEAAEFRFKWGYEMPVDVLAKWIADKAQVYTQHAYMRPLGVVAMVLGYDEEKNAQLFKCDPAGHFFGHKATSAGLKEQEAINFLEKKMKDDPKFTYDETVQIAISALQSVLQEDFKATEIEVGVVRKDDRVFRALTTEEIDQHLTAISERD
Protein: Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1) (Q06393)
Organism: Rattus norvegicus (Rat)
Function: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9WUB7}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Barttin
- Solute carrier family 12 member 1-chloride cotransporter 1)
Sequence:
MEELVGLREGSSGKPVTLQELWGPCPRIRRGVRRGLEWLKERLFRVGEDWHFLVALGVLMALISYAMNFAIGRVVRAHKWLYREVGDGHLLRYLSWTVYPVALLSFSSGFSQSISPFSGGSGLPELKTMLSGVVLEDYLDIKNFGAKVVGLSCTLATGSTIFLGKVGPFVHLSVMISAYLGRVRAKTIGETENKAKEIEMLSAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWNYWRGFFAATCGAFMFRLLGVFNSEQETITSIYKTRFRVDVPFDLPEIFFFVALGFICGVLSCAYLFCQRTFLRFIKTNRYTSRLLATSKPSYAALVALVLASITYPPGVGRFMASRLSMAEHLHSLFDNNSWALMTRNSSPPWPAEPDPQNLWLEWCHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFIIGAAIGRLLGEALSVAFPEGIVAGREVNPIMPGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAISQNCQPSFYDGTIMAKKLPYLPWIRGRQIGSYPVTVEHFMNCNLTTLAKDTPLEEVVKVVTSTEVSQYPLVETRESQTLVGIVERTHLVQALQTQPASWAPGQERFLQDILAGGCPTQPVTLQLSPETSLYQAHSLFERLTLQSLFVTSRGKAVGSVSWAELKKAISTLINPPAPK
Protein: Protein kinase, putative (EC 2.7.1.-) (Q57TW4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGCGASSRVVESDDRERHKSPHSAAECSPKLGAAEVSPNAKLKEVPSVSTSVIEGLKGHQGTFVMSKFSNDSMTTSASYLNQPNTNEALPPIQTAEASFAPSDAADSTRGNGRSPFASNFTDSNVATSFLRIPHLNSEVDSDARFSSNAFESRCRSGSVVSTGVCNVPILPTFSHCNSRDSRFQSPCGVNRCDSYSPTARPHECSRRCGWGEYETLRRLSINNSMDGTNGTIADTATTASSVEHSNNYAGHRYSFIGTDCGCSSLFYDPCERCSRCILDTEAVYRCDLCMLIFCTDCHAEIGAALHRHKLTSFRRAVNSNVTDSFLINKGRNRDGNKVINEYVVIKVLGRGSHAKVNLVQHHQDRTFYAVKILRCDRTKKIHHGIVSKSSTASDDDLLREIAVMKFVSHPNLIKLKEVIDDVESHKVYVIMEYCAKGPVHVHGEPPLPPEKVRKYGCDILSGLLQLHAQYLYHWDIKPANCLVDDNDVAKIADFGACGSSTRTCKVGGTPAYSCPEQFAGTHIGGHVADSWAFAMTLYQMSHGTLAYSTTSISSLRDSMLDPTPLPIQEGVEPELKDLLRRMLNKDMSQRMMLHDAMKHSYFSGYVTQSYTTVEPSNESAGCITEDLYARAQQAVLRGKRVGDFFHGVQFVRRIRRMMVRHINTHDVDDEDDFFPELPEASSLESTQRLVTNEADIHEVHKIVSSFVGDAVRGALRIDGILMTTLHSFVAEAAPLVSKLCCSNNKLTCVGTVDFSKFQHLRVLQICENSLRQFPLDVLHAPRLQFLDLSHNHIKDIPPALTCARELQTLCMNHNQVAYVGCNECGASVLSGESMQKVVLTANPLRHLPAEITSCSKLELILDDAPSLLEEWYASINQSTSVSITWNDIYPCRVYPEVPLFVASKSIKLYNLTILEALGTRNVVLTQFESWLPTGEVNSAAMEEHVRRRQKESVRVNGNDSECEIRSPVVRKTAMNVGDCLPIPNILSKSVCRFLHSYFILEEKTSYTVSAYGALKNYLTTCLGRNESVVVFLDERRDSQNTRDTIVAVLCEVLMAAKGGKRTLSGCISDVVDATRGLYA
Protein: Microtubule-associated protein 10 (Microtubule regulator of 120 KDa) (Q9P2G4)
Organism: Homo sapiens (Human)
Function: Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23264731}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23264731}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23264731}. Midbody {ECO:0000269|PubMed:23264731}. Note=Localized at stabilized microtubules (MTs) during interphase and to the mitotic apparatus during mitosis. Localized at spindle poles in metaphase and spindle midzone during telophase. Colocalized with Polo-like kinase PLK1 to the center of spindle midzone. Localized at the midbody during cytokinesis. Colocalized with acetylated-tubulin at MTs.
Interaction partners:
Sequence:
MAASLSERLFSLELLVDWVRLEARLLPSPAAAVEQEEEEEEKEQGEASSPRGLCPAVAFRLLDFPTLLVYPPDGPGAPAAEPWPGVIRFGRGKSCLFRLQPATLHCRLLRTPLATLLLQLPPGRPTPTPQLLGACDISLATAAHRVVGPAASGCSHRHRGRFPLHNRVGERTGDIALAYRLTDLGSRLLSQLERPLTFTRTGGGAEVSPQTQQERQQLQQPASQPSPKEADKPLGELEIPEAQKDLKEMVKSKAECDNVGSVENGKTNSVVTCSGAGNGRNVSSLNEEVTELDMETNIFCPPPLYYTNLTQEKPPPAQAKITIEPQMNAPEEMDDASPEKKRVNPPAHRSCLKHPSSAAHEHPPMLVNPPHIQNIGATNQTCQTEQNRINTIRQLPLLNALLVELSLLYDQPVTSPAHIHPHLAWLYRTEDKKSPESSAKSTCRSEAKKDKRSVGGCEKSVSLQYKKNQIENYKEDKYSEKSSGALHKRVPKGRLLYGLTNTLRLRLKLTNPDMLVVHEKRELYRKRQSQMLGTKFRIPSSKVKLLSSAEQSQKPQLPEDKYLDSDASFTENSDTSRQISGVFDEPSTSKETKLKYATEKKTVDCSKNRINNVSLEEVVSPANSIIPERLTPTNILGGNVEMKIQSPCVFQQDAVVDRIVDKEIDIRQVKTTDNDILMADISDKRTGKNSCYENISELKYSDDLSSPCYSEDFCTSEDTSRSFKAHDSSSRTENPKHSQYTSKSSDTGVSKKKNSSDRSSILSPPFSAGSPVHSYRKFHISKTQDKSLEEASSISASDLSSTHWTEQKENQIDQNSMHNSEITKRAQDISVKTRSSWKSLEKSQSPQTSQVSSYLPSNVSELNVLDSSTSDHFEEGNDDVGSLNISKQCKDICELVINKLPGYTM
Protein: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 (Q3SXY7)
Organism: Homo sapiens (Human)
Function: Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (By similarity). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina. Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (By similarity). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (By similarity). May also have a role in cone synapse formation (By similarity). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi. Could be a regulator of the FGFRs.
Subcellular location: Cell projection, dendrite {ECO:0000269|PubMed:23246293}. Perikaryon {ECO:0000250|UniProtKB:W8DXL4}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Punctate expression at dendrite tips. {ECO:0000269|PubMed:23246293}.
Interaction partners:
- Transient receptor potential cation channel subfamily M member 1
- Visual pigment-like receptor peropsin
- Calcium-binding protein 4
- Voltage-dependent L-type calcium channel subunit alpha-1F
- Probable G-protein coupled receptor 179
- Metabotropic glutamate receptor 6
Sequence:
MHLFACLCIVLSFLEGVGCLCPSQCTCDYHGRNDGSGSRLVLCNDMDMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSERTGDHPEWDVQPGSGRSTSVSSASSYLWSSSFSPTSSFSASTLSPPSTASFSLSPFSSSTVSSTTTLSTSISASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPASTSKKEELALLDQTMLTETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLYSKYGGKDLLLLNADSSKNQVTIDGLEPGGQYMACVCPKGVPPQKDQCITFSTERVEGDDSQWSLLLVVTSTACVVILPLICFLLYKVCKLQCKSEPFWEDDLAKETYIQFETLFPRSQSVGELWTRSHRDDSEKLLLCSRSSVESQVTFKSEGSRPEYYC
Protein: Uncharacterized protein Rv3786c (P9WKW9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- DNA integrity scanning protein DisA
- Uncharacterized protein Rv2891
- Putative S-adenosyl-L-methionine-dependent methyltransferase Rv3787c
- Probable transposase
- Tat
Sequence:
MRILAMTRAHNAGRTLAATLDSLAVFSDDIYVIDDRSTDDTAEILANHPAVTNVVRARPDLPPTPWLIPESAGLELLYRMADFCRPDWVMMVDADWLVETDIDLRAVLARTPDDIVALMCPMVSRWDDPEYPDLIPVMGTAEALRGPLWRWYPGLRAGGKLMHNPHWPANITDHGRIGQLPGVRLVHSGWSTLAERILRVEHYLRLDPDYRFNFGVAYDRSLLFGYALDEVDLLKADYRRRIRGDFDPLEPGGRLPIDREPRAIGRGYGPHAGGFHPGVDFATDPGTPVYAVASGAVSAIDEVDGLVSLTIARCELDVVYVFRPGDEGRLVLGDRIAAGAQLGTIGAQGESADGYLHFEVRTQDGHVNPVRYLANMGLRPWPPPGRLRAVSGSYPPATPCTITAEDR
Protein: Oxidoreductase HTATIP2 (E9PI87)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPGEWLVRKFFGSLPDSWASGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSLKP
Protein: Rho guanine nucleotide exchange factor 18 (A0A590UK10)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
XTSVKRRLSCLRSRVTRQKEKGKSPAHLKDKGQDARERRECVNGHQLLQGTFSGPSSCPLCGKPFLSSASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGGKDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLP
Protein: Zinc finger SWIM domain-containing protein 4 (Q8C7B8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MEPPAAKRSRGCPAGDEPGTGARRSRPEPLLDLSAKRVAESWAFEQVEERFSRVPEPVQKRIVFWSFPRSEREICMYSSLGYQPPEGEQDTRVPFTRGLHLLQSGAVDRVLQVGFHLSGNIREVGGPGEPEHLYHVSISFDRCKITSVSCGCDNRDLFYCAHVVALSLYRIRHARQVELRLPISETLSQMNRDQLQKFVQYLISAHHTEVLPTAQRLADEILLLGSEINLVHGAPDPTAGAGTEDANCWHLDEEQIQEQVKQLLSNGGHYGASQQLRSMFSKVREMLRARDSNGARMLILMTEQFLQDPRLALWRQQGAGMTDKCRQLWDELGALWVCVILSPHCKPDERSGWLQLLGTWDKLDVCPLEEGNYSLDIPSLQPALTSRTGSEDEEEVTAASPRRTVFSRALQAGELHWNDSHLQRILASDSCGPTLTGSMGSDKPTFDPQGHPIWLGEPFPTACARVDTLRAHGYPHKALRLACAIINTLRLQRRHQLESYKQQKKELLQKGATGVTSTEGWVGHPLDPIGCLCRALLEACRLEEEPHSLFPDSAPEKRKLAYQHVLVPGSPGESYLALALEVALLGLGQQRALPEGLYAQDKVVRNEEQLLALLEEVELDERLVQVLRKQAGLLLEGGPFSGFGEVIFRESVPMHTCARYLFTALLPHDPDLAFRLALRAMRLPVLETTFPAGESHPNPLDSIMSNRFPRWFILGHLETRQCELASTMLTAAKGDTKWLHAVLGSVQQNIHSPALLFKLAQDACKTATPASAPPDTVLLGIALELGLQVMRMTLNTMTWRRREMVRWLVSCATEIGPPALMSIMKNWYSLFTPVEAVTIVAVTGTTHATLLRLQLDTAGREELWACARTLALQCAMKDPQNCALPALTLCEKNHAAFEAAYQIVLDAAAGGLGHAHLFTVARYMEHRGLPLRAYKLATLALAQLSIAFNQDSHPAVNDVLWACSLSHSLGRHELSAIVPLIIRSIHCAPMLSDILRRWTLSAPGLGPLGARRATKPLGTDRAPLCQLLDAAVAAYITTSHSRLTHISPRHYGDFIEFLGKARETFLLAPDGHLQFAQFLENLKQTYKGKKKLMLLVRERFG
Protein: Esterase PE11 (EC 3.1.1.6) (PE family protein PE11) (Q79FR5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in cell wall lipids remodeling and in virulence. Restricts the biofilm growth and is essential for the optimal intracellular survival of M.tuberculosis. Shows esterase activity with a preference for short-chain esters, particularly pNP-acetate (C2) and pNP-butyrate (C4). Has weaker activity with pNP-octanoate (C8), pNP-laurate (C12) and pNP-myristate (C14). Shows weak long-chain triacylglycerol (TAG) hydrolase activity in vitro. Not necessary for PPE17 stability or for its localization on the mycobacterial surface.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:26157429}. Note=Cell wall associated protein. {ECO:0000269|PubMed:26157429}.
Interaction partners:
- PPE family protein PPE17
Sequence:
MSFVTTRPDSIGETAANLHEIGVTMSAHDDGVTPLITNVESPAHDLVSIVTSMLFSMHGELYKAIARQAHVIHESFVQTLQTSKTSYWLTELANRAGTST
Protein: Prostatic spermine-binding protein (SBP) (P08723)
Organism: Rattus norvegicus (Rat)
Function: Spermine-binding protein is an androgen regulated ventral prostate glycoprotein that binds various polyamines.
Interaction partners:
Sequence:
MLLLVTLALLAGPTCRAQNILGNNVGTYFYVAGEEHGQLRGIRIFLTVIDLIKGIQLRFGGNWSDVYGSRSLKYKEFLLEDGEHVTQVSGTRKLCLTSLSFTTNKGRVVTFGVRRGLSFNESGGSDKYLVTVNGLYAPGLCLNGMGFKWKNIHDDFDDNDDDKEDDDDEHDDDNEEDHGDKDNDNDHDDDHDDDDDDKEDDNEEDVDDERDDKDDDEEDDDNDKENDKDDGEGSGDDDDNDDEDDDKDDDGGSGDDGDDGDDDEDDDGGDDDNGDEEEE
Protein: Uncharacterized protein ycf68 (P0C304)
Organism: Oryza sativa (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MAYSSCLNRSLKPNKLLLRRIDGAIQVRSHVDLTFYSLVGSGRSGGGTTAPLFSRIHTSLISVWRAISRAQVEVRPQWENGAPNNASSQTKNYEITLSFWGDGGIVPFEPFFHAFPGGLEKAAINRTSLILPS
Protein: phosphatidate phosphatase (EC 3.1.3.4) (Q8SXP0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- O-acyltransferase
- Phosphatidate cytidylyltransferase, photoreceptor-specific
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- GH11618p
- FI05338p
- 1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform E
- CTD nuclear envelope phosphatase 1 homolog
- Acyltransferase
- Serine/threonine-protein kinase mTor
- 1-Acylglycerol-3-phosphate O-acyltransferase 4, isoform A
Sequence:
MNSLARVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPVDIQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDKNASEELLLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTTQKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQIKPDVNLTTVTTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNIDEGDAPISSATNNNNTSSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPRLDLDIHFFSDTEITTPVGGGGAGSGRAAGGRPSTPIQSDSELETTMRDNRHVVTEESTASWKWGELPTPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIYLSDLDAGSMDPEMAALYFPSPLSKAASPPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNNRYLDFVAMSMCGMSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYTWMAACPIVMTMITFQKPLTHDAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQDAAPNHLNNTHGMPLGKDEKDGDQAAVATQTSRPTSPDITDPTLSKSDSLVNAENTSALVDNLEELTMASNKSDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVISDIDGTITKSDVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYLRSIRQGNVMLPDGPLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDLFPDKEPFYAGYGNRINDVWAYRAVGIPIMRIFTINTKGELKHELTQTFQSSGYINQSLEVDEYFPLLTNQDEFDYRTDIFDDEESEEELQFSDDYDVDVEHGSSEESSGDEDDDEALYNDDFANDDNGIQAVVASGDERTADVGLIMRVRRVSTKNEVIMASPPKWINS
Protein: Endophilin-A3b (SH3-domain GRB2-like 3) (Q6TGT7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Early endosome {ECO:0000256|ARBA:ARBA00004412}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
- Synaptojanin-1
- Cbl proto-oncogene, E3 ubiquitin protein ligase.
- E3 ubiquitin-protein ligase CBL
- E3 ubiquitin-protein ligase CBL
- Ubiquitin-like-conjugating enzyme ATG3
- Epidermal growth factor receptor precursor.
- E3 ubiquitin-protein ligase parkin
- Vacuolar protein sorting-associated protein 35
Sequence:
MSVAGFKKQFHKASQLLKEKINGVEGTKLDEEFLSMERKTEITHKLILDIVPKTIGYLQPNPAYRAKLSMLSTVSRIRGHVKAVGYPQTEGILGDCMLQYGSELGAESGFGFALLEMGEALKQVAQARDCMDVRVKRAFIDPLQSLQQKELKEIGFHLRKLEGRRLDFDYKKRRKGKIADSEIKKAFDKFEESKEMAERCMFNLLEKDVQRMQHLSGLLEAVIDYHRQSSQILENLRSNLQTKIRDASNKPKREFASKSVASTVCYSDIYGFSTCSSGPSSDTEITEALSEKYAPVVVHRPEQVTIKTPTTDKPASINDRAPPLDQPCCQALYSFQAENQGELGFKEGDIIILTSQIDENWYEGMIRGQSGLFPMNYVKVLVPLPQ
Protein: Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) (Q8C167)
Organism: Mus musculus (Mouse)
Function: Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:23321636, ECO:0000269|PubMed:23485813}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23321636}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23485813}. Golgi apparatus {ECO:0000269|PubMed:23485813}. Nucleus {ECO:0000250|UniProtKB:Q4J6C6}. Note=Co-localizes with AP-1 in the trans-Golgi network (PubMed:23321636). Co-localizes with MAP2 and ACTB on the cytoskeleton (PubMed:23485813). Co-localizes with STX6 and GOSR2 at the Golgi apparatus (PubMed:23485813). {ECO:0000269|PubMed:23321636, ECO:0000269|PubMed:23485813}.
Interaction partners:
- Amino acid transporter heavy chain SLC3A1
- Calmodulin-lysine N-methyltransferase
- Protein phosphatase 1B
Sequence:
MLQTAKFSLRALKHSIPHLGNCMQKQSYRNVAGPYYSRVRLKKYHLTKCLQNKPRIAGLARNIPSRSFSCKDLLPIKPESEKPISENMDAFEKVRTRLETQPQEEYEVVNAEIKHGGFVYYQEGCCLVRSKDEEADSDNYEVLFNLEELKLDQPFIDCIRVAPDEKYVAAKIRTEDSETSTLVVVKLSDQPVMEASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATFGDNKRNERFYTEKDPSYFVFLYLTKDSRFLTLNIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGMLYYVEHRDDELYILTNVGEPTEFKLMRTAADAPAIMNWDLFFTMKRNTKVVDLDMFKDHCVLFLKHSNLLYVNVIGLADDSVRSLKLPPWACGFIMDTNSDPKNCPFQLCSPIRPPKYYTYKFAEGKLFEETGHEDPITKTSRVLRIEAKSKDGKLVPMTVFHKTDSEDLQRKPLLVHVYGAYGMDLKMNFRPEKRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLVACIKTLHSQGFSQPSLTTLSAFSAGGVLVGALCNSKPELLRAVTLEAPFLDVLNTMLDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPCQNIKPQHYPSVHITAYENDERVPLKGIVNYTEKLKEAVAEHTKGAGEGYQPPNIILDIQPGGNHVIEDSHKKITTQMKFLYEELGLDSTDAFEALKKYLKF
Protein: Uncharacterized protein (Q586A6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Ribosomal protein L30 ferredoxin-like fold domain-containing protein
- Large ribosomal subunit protein mL46
- Uncharacterized protein
- KOW domain-containing protein
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Large ribosomal subunit protein uL29m
Sequence:
MLRFTRLFREMAPELQLEYMPVLFTRTILGPQGGFAGEERLVKLEVARKYMEAGHAVTPTEELRRGLWCYNPDTDKYDCFIERNEEFLDFAARKRQWLDVYWRVNTGYLLFGRQSWGQGFLINCPLRKRDVAQKLWEQYKVRIDPRLIEFREKDRRTGIQELGHNWCWLYLPGAEELGINREVYDNKRVKVRIHVRKMNSMFALY
Protein: Nuclear distribution protein nudE homolog 1 (NudE) (mNudE) (Q9CZA6)
Organism: Mus musculus (Mouse)
Function: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9NXR1}. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. Also localizes to the cleavage furrow during cytokinesis. Colocalizes with RAB9A to membrane vesicles (By similarity). {ECO:0000250|UniProtKB:Q9NXR1}.
Interaction partners:
- Disrupted in schizophrenia 1 homolog
- Platelet-activating factor acetylhydrolase IB subunit beta
- Nuclear distribution protein nudE-like 1
- Centriole and centriolar satellite protein OFD1
- Nuclear migration protein nudC
- Centromere protein F
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase PLK1
- 14-3-3 protein epsilon
- Cell division cycle protein 20 homolog
Sequence:
MEDSGKTFESEEEETNYWRDLAMTYKQRAENTQEELREFQEGSREYEAELEAQLQQIETRNRDLLSENNRLRMELESVKEKFEMQHSEGYRQISALEDDLAQTKAIKDQLQKYIRELEQANDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQELAVQQKQDKPRTPMPGSGQAKRTDMAVQATGSVPSTPVAHRGPSSGLNTPGMFRRGLDSSTSGTPLTPAARISALNIVGDLLRKVGALESKLASCRNFMYDQSPSRTSGPASGRGTKNRDGVDRRPGSTSVGDKGSGKRLEFGKPASEPASPALPSAQGVVKLLL
Protein: Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) (P46527)
Organism: Homo sapiens (Human)
Function: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Subcellular location: Nucleus. Cytoplasm. Endosome {ECO:0000250}. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). {ECO:0000250}.
Interaction partners:
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase 6
- G1/S-specific cyclin-D3
- G1/S-specific cyclin-E1
- G1/S-specific cyclin-D1
- S-phase kinase-associated protein 2
- Cyclin-dependent kinase 2
- Cyclin-A1
- G1/S-specific cyclin-D2
- Cyclin-A2
Sequence:
MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT