wanglab/gogpt-training-data huggingface dataset:
Protein: Forkhead box protein J1 (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4) (Q63247)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q61660}.
Interaction partners:
Sequence:
MAESWLRLCGAGPGEEAGPEGGMEEPDALDDSLTSLQWLQEFSILNAKAPTLPPGGTDPLGYHQVPGLVAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQEPSTAPWGGPLTVNREAQQLLQEFEEATGEGGWGTGEGRLGHKRKQPLPKRVAKVLRPPSTLLLTQEEQGELEPLKGNFDWEAIFEAGALGEELSSLEGLELSPPLSPSSHGEVDLTVHGRHINCPATWGPPVEQATDSLDFDETFLATSFLQHPWDESSSGCLPPEPLFEAGDATLAADLQDWASVGAFL
Protein: Pentatricopeptide repeat-containing protein At4g28010 (Q9SUD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Retrotransposon ORF-1 protein
- Retrotransposon ORF-1 protein
- Retrotransposon ORF-1 protein
- Putative DNA
Sequence:
MRFWTSAAAAEILRRDEHVVRKLLNPRVYSKLVNAFSETETKLRSLCEDSNPQLKNAVSVFQQAVDSGSSLAFAGNNLMAKLVRSRNHELAFSFYRKMLETDTFINFVSLSGLLECYVQMRKTGFAFGVLALMLKRGFAFNVYNHNILLKGLCRNLECGKAVSLLREMRRNSLMPDVFSYNTVIRGFCEGKELEKALELANEMKGSGCSWSLVTWGILIDAFCKAGKMDEAMGFLKEMKFMGLEADLVVYTSLIRGFCDCGELDRGKALFDEVLERGDSPCAITYNTLIRGFCKLGQLKEASEIFEFMIERGVRPNVYTYTGLIDGLCGVGKTKEALQLLNLMIEKDEEPNAVTYNIIINKLCKDGLVADAVEIVELMKKRRTRPDNITYNILLGGLCAKGDLDEASKLLYLMLKDSSYTDPDVISYNALIHGLCKENRLHQALDIYDLLVEKLGAGDRVTTNILLNSTLKAGDVNKAMELWKQISDSKIVRNSDTYTAMIDGFCKTGMLNVAKGLLCKMRVSELQPSVFDYNCLLSSLCKEGSLDQAWRLFEEMQRDNNFPDVVSFNIMIDGSLKAGDIKSAESLLVGMSRAGLSPDLFTYSKLINRFLKLGYLDEAISFFDKMVDSGFEPDAHICDSVLKYCISQGETDKLTELVKKLVDKDIVLDKELTCTVMDYMCNSSANMDLAKRLLRVTDDKEERDK
Protein: Putative serine/threonine-protein kinase-like protein CCR3 (EC 2.7.11.1) (Protein CRINKLY 4 RELATED 3) (AtCRR3) (Q9LY50)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine-protein kinase.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- CLAVATA3/ESR
Sequence:
MKRFINSTVTFSVTVTIAVIIFFLLSPVTSLGSGSTYAVVYGSDTVCALISGQPTQRILCYDTRLNINVTLNPGVSFSSIAAGDNFLCGIRSGGYSLLCWDNIGSYSPNRKRIYQNDNVLLETLSVGDKQICATVNGTNSLKCWRGSVSDQSKPPNERFRSISSGVGFSCGVSIRNNRILCWGTDPVKSNQIQTGFGNTPMVTISAGKSHACGLNTTGNLICIGNNDSGQLNVIAPDQPNLYSSSLSLGSNFTCAMRISNNSVVCWGGGAERFNNVTDSISFESISSGPGLICGLISSNLSIMCWNPTNFSRIFLPFPEVLPGPCVESSSSSLCSCGVYPQSDKLCSGTGSICKSCPIQFPASPPSQFPLPPPPPPPPPSPSTSSPPSKALTRGLLAFAIVGSVGAFAGICSVVYCLWTGVCLGKKKVHNSVQPTITRGGSNSRSNSSNSRSLSIRRQGSRMLSMRRQRSGTSSMKHADKAEEFSFSELASATGNFSLENKIGSGSFGVVYRGKLNDGREVAIKRGEVNAKMKKFQEKETAFDSEIAFLSRLHHKHLVRLVGYCEEREEKLLVYDYMKNGALYDHLHDKNNVEKHSSLINSWKMRIKIALDAARGIEYLHNYAVPPIIHRDIKSSNILLDSNWVARVSDFGLSLMGPVLGKDHNPYQRPTKAAGTVGYIDPEYYSLNVLTDKSDVYGLGVVLLELLTGKRAIFRNNGDVEEEEGCVPVHLVDYSVPAITADELSTILDPRVGSPELGEGDAVELVAYTAMHCVNAEGRNRPTMTDIVGNLERALDLCGDSHGSISSGICSIVSD
Protein: Tubulin-specific chaperone E (Tubulin-folding cofactor E) (Q20068)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Tubulin-specific chaperone D
- Tubulin-specific chaperone B
- Tubulin-specific chaperone A
- Spastin homolog
- C-CAP/cofactor C-like domain-containing protein
- ADP-ribosylation factor-like protein 2
- Tubulin alpha-3 chain
- Eukaryotic translation initiation factor 4E-5
Sequence:
MEIGQRVRINFEVATVRYIGEVDGYGSQRWVGLEWDDPTRGKHDGIVRGKRYFQTRHPNGGSLMKHEIVPKPTDLLFEIKDRYIEEESVETEIELAQSNKKIELIGMDQTAAKQSNIEKLINIVLDNRSVGFPPSSDSPQFILCRELNLYGNLLYKWKTVRQILEYFPRIQELNLRRNRMQCFNEEEDDDESEGDDHVYSDSCKKLVISECNLSENSIDSILLRFPSTSDVVAFGNDLTRFSVSEAVSSRLTSLDLEDNPFKTLDSIHGTFPNLTQLSVANCGITSLNGFDGSIKFPKLEYLNIKRNSIVEWKSVNSIRSLKSLKRLLFDCKKLSTEKGVHAYEIVIAKLSTLIDLNRFDVSEVERRSAEIRFLNKYAGLNDNEDHQDDIKRLIEIHGEPTLDTAKKGLAVVKIRIECGNRVETRRLPLGMSIQKIRDMLARLFKVPNTSKIRLYLVMSEKAKQHRIELENPLREFGHYSPSEDRDILVVEHD
Protein: Urokinase plasminogen activator receptor (Q9TVA9)
Organism: Bos taurus (Bovine)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
CLQCENTTSCSVEECTPGQDLCRTTVLSVWEGGNEMNVVRKGCTHPDKTNRSMSYRAADQIITLSETVCRSDLCNKPNPGRDATVSRNRYLECASCSSTDLSCERGWDQTMQCLKSRDQCVDVITHRSLKENPGDERHIRGCGILPGCPGPTGFHNNHTFHFLRCCNTTKCNAGSVLELQNLPPNGLQCYSCEGNGAHRCSSEE
Protein: RNA-binding protein 4 (Lark homolog) (mLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Q8C7Q4)
Organism: Mus musculus (Mouse)
Function: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.
Subcellular location: Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation (By similarity). {ECO:0000250}.
Interaction partners:
- Eukaryotic translation initiation factor 4E type 2
- Endothelial PAS domain-containing protein 1
- Protein argonaute-2
- Serine/arginine-rich splicing factor 3
- YTH domain-containing family protein 2
Sequence:
MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINVEASKNKSKASTKLHVGNISPTCTNQELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQYGAVRTPYTMSYGDSLYYNNTYGALDAYYKRCRAARSYEAVAAAAASAYSNYAEQTLSQLPQVQNTAMASHLTSTSLDPYNRHLLPPSGAAAAAAAAAACTAASTSYYGRDRSPLRRATGPVLTVGEGYGYGHDSELSQASAAARNSLYDMARYEREQYADRARYSAF
Protein: Piezo-type mechanosensitive ion channel homolog (F4IN58)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Pore-forming subunit of a mechanosensitive non-specific cation channel, that conducts both sodium and potassium ions.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Zinc knuckle
- Timeless family protein
- Probable inactive protein kinase At3g63330
- DNA replication licensing factor MCM4
- Cell division cycle 45
- Protein ENHANCER OF LHP1 1
- Serine/threonine-protein kinase ATR
- Cell cycle checkpoint protein RAD17
- DNA replication licensing factor MCM3
- Protein BPS1, chloroplastic
Sequence:
MASFLVGFLLPSLLLAAALINWSVISFLDLIAFLLVHYIAPEIGYRFQRRHWLLWPIFIFSFAVFLAQVVYLVIWAALGQDWDTPDTGWMRVIGFMILKSWRNPTVMYFLALQLLTSLVALADIYSSRFGFARWRDTWWSHFSGIFEHLGSHLRVASCLLLPAVQLAVGICNPSWVSLPFFIGSCAGLVDWSLTSNVSGLFRWWRVLYIYAGFNIVLLYLYQLPINFSDMIRWIASFIGLFRISLETEGPDICSGLFLVLFYIMLSYVRSDLEDMDFIMSTSENNLAERLLPPKYSFFIRESRAGVRHTNVLLRGAVFKTFSINFFTYGFPVSLFALSFWSFHFASLCAFGLLAYVGYIIYAFPSLFQLHRLNGLLLVFILLWAVSTYIFNVAFSFLNTKVGKFGLGMLVALGNLVNNSVFLYLSEESSRSSNERSYVEADEETKVLVVATIAWGLRKCSRAIMLALIFLIAMKPGFFHAVYVIFFLMYLLSHNINRKIRKSLILLCEVHFALLYILEIDLVSNSLKQEGSASREVLFQLGLLRSESSWDFLEIALLACFCAIHNHGFEVLFSFSAIVRHTPSPPIGFSILKAGLNKSVLLSVYSSPSSSYSQDNTTYERHIASFLSAIGQKFLSMYRSCGTYIAFITILISVYLVKPNYVSFGYIFLLLLWITGRQLFEETKRRLWFPLKAYAVLVFMFIYCLSSFVSLQLWLSGFIDLYFYLGYNSKAPLLDNVWESLAVLIVMQLYSYERRQSGHYIPGQSSLLHPGVFGFFERFLAWHGQKILFAALFYASLSPISVFGFVYLLGLVICTTFPKSSSIPSKSFLIYTGFLVSAEYLFQLWGMQAQMFPGQKYAELSFYLGLRVYEPGFWGIESGLRGKVLVVAACTLQYNVFRWLERTSGLTVIKGKYEEPCPLFVSAEDTTASVSSSNGENPSSTDHASISMKQGEATSNSWPFFSPRGNQGAGFLHPKTGGSESGSSRKFSFGHFWGSIKESHRWNRRRILALKKERFETQKNLLKIYLKFWIENMFNLYGLEINMIALLLASFALLNAISMVYIALLAACVLLRRRVIQKLWPVVVFLFASILAIEYVATWNSFLPSDQAPSETSVHCHDCWSIAALYFKFCRECWLGVRVDDPRTLISYFVVFMLACFKLRADHISSFSESSTYHQMKSQRKNSFVWRDLSFETKSMWTVLDYLRLYCYVHLLDVVLILILITGTLEYDILHLGYLAFALVFARMRLEILKKKNKIFRFLRVYNFVLIIFSLAYQSPFVGNFNDGKCETVDYIYEVIGFYKYDYGFRITARSALVEIIIFMLVSLQSYMFSSQEFDYVSRYLEAEQIGAIVREQEKKAARKTEQLQQIREAEEKKRQRNLQVEKMKSEMLNLRVQLHRMNSDSNFGVASPRTEGLRRRKSPYLIPDSGAASPEIDGVVHRKEEQPIDEDSQYPFEAHEFPVSTTPEALDSPEYSFGASPCEITEVQQDLDVMSMERERKQKSEGKENPLISAVQLIGDGVSQVQFIGNQAVNNLVNFLNISPENSDTNEQSSVDDEVYDEMESQKRKHTPFERSTSLQSDRSSDGTSFQIGRIFRHIWSRMQSNNDIVCYCCFIIAFLWNFSLLSMVYLAALFLYALCVHTGPTHIFWVIMLMYTEIYILLQYLYQIIIQHCGLSIDAPLLHELGFPTQRIKSSFVVSSLPLFLIYIFTLIQSSITVKDGDWVPSADFTSRRNARGSQKDLTRIRLSQRILDVFKKLRDSAKLVIRSIYRYWISLTRGAESPPYFVQVTMDVHMWPEDGIQPERVECRMNQLLRLVHNERCEKGNPDLCPYSSRVHVQSIERSTETPNEALVVLEVEYASPTNGCSSAEWYKSLTPASDVAKEIRKAQHSGLGEGTGFPYPILSVIGGGKRDTDLYAYIFGADLIVFFLVAIFYQSVIKNKSEFIDVYQLEDQFPFDFVIILMVIFFLIVVDRVIYLCSFATGKVVYYLFSLILFTYAVTEYAWSIYPTQQHAAGLALRIIFLAKAMSLALQAIQIRYGLPHKSTLYRQFLTSEVSRINYYGYRLYRALPFLYELRCVLDWSCTATSLTMYDWLKLEDVNASLYLVKCDTVLNRATHKHGEKQTKMTKCCNGICLFFILLCVIWAPMLMYSSGNPTNIANPIKDASVQIDLKTVGGKLTLYQTTLCERISGDNIDLGLDLGSQSFLPTYNKNDIQLICCQADASVLWLVPDTVVTRFIQSLDWDTDMDITFTWVLNRDRPKGKETVKYERSVDPLDLPKRSDIQMVLNGSMDGFRVHNLYPKFFRVTGSGDVRSFEDQTDEVSADILINHANFKWWWSFHNLKASENISACEGMDGPVAIIMSEETPPQGFLGDTLSKFSIWGLYITFVLAVGRFIRLQCSDLRMRIPYENLPSCDRLIAICEDLYAARAEGELGVEEVLYWTLVKIYRSPHMLLEYTKLDYDA
Protein: Checkpoint protein (G5EFI9)
Organism: Caenorhabditis elegans
Interaction partners:
- Cell cycle checkpoint protein RAD1 homolog mrt-2
- Cell cycle checkpoint protein hpr-9
- Homolog of S. Pombe Rad
- Replication factor C subunit 4
- Replication factor C subunit 2
- Replication factor C subunit 3
- Probable replication factor C subunit 5
- Mitotic checkpoint protein bub-3
- Protein hsr-9
- SAP domain-containing protein
Sequence:
MKFSSLLQDTAAIDVFIKILTSVSKLSKKRCCVKIEKNALNFICCSGLHDGGSWFSLSIPYSSQIFRKFDMVGMNPRNEEQNLIYFELEIDSLVRVLPGGHCYLKLKLSKSQKDEPMLSVEVRNPEADIVSHQIPITIILSKYWNSYSRPSIGHRKMSISMPPPKMMSRFLHVFKNMNTRVVKLTASTSGDLRISTKIETGEIDVSFSDLQTNPSETDSQEDTAKVQLMIRNISPLFQSFANTRTRAKMNIISNRMAEFNFHNEDCVLSYIVGNVSD
Protein: Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase) (Q9D0K2)
Organism: Mus musculus (Mouse)
Function: Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (By similarity). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor (3-oxo acid) carboxylate and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:B2GV06}.
Interaction partners:
- D-beta-hydroxybutyrate dehydrogenase, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Hydroxymethylglutaryl-CoA lyase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- Dehydrogenase/reductase SDR family member 6
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
- Acetoacetyl-CoA synthetase
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Acetyl-CoA acetyltransferase, cytosolic
Sequence:
MAALKLLSSGLRLGASARSSRGALHKGCVCYFSVSTRHHTKFYTDPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLLLRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYEKRIERLSLRKEGDGKGKSGKPGGDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGGHVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIKKSTGCDFAVSPNLMPMQQIST
Protein: Maltose permease MAL31 (Maltose transport protein MAL31) (P38156)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: High-affinity uptake of maltose and maltotriose. Also transports turanose but not alpha-methylglucoside, melezitose or trehalose.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Alpha-glucosidase MAL32
- Alpha-glucosidase MAL12
- Maltose fermentation regulatory protein MAL33
- Maltose fermentation regulatory protein MAL13
- Protein REG2
- Oligo-1,6-glucosidase IMA1
- Oligo-1,6-glucosidase IMA5
- Putative ATP-dependent RNA helicase ECM32
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Sequence:
MKGLSSLINRKKDRNDSHLDEIENGVNATEFNSIEMEEQGKKSDFDLSHLEYGPGSLIPNDNNEEVPDLLDEAMQDAKEADESERGMPLMTALKTYPKAAAWSLLVSTTLIQEGYDTAILGAFYALPVFQKKYGSLNSNTGDYEISVSWQIGLCLCYMAGEIVGLQMTGPSVDYMGNRYTLIMALFFLAAFIFILYFCKSLGMIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWAFGQLFAAGIMKNSQNKYANSELGYKLPFALQWIWPLPLAVGIFFAPESPWWLVKKGRIDQARRSLERTLSGKGPEKELLVSMELDKIKTTIEKEQKMSDEGTYWDCVKDGINRRRTRIACLCWIGQCSCGASLIGYSTYFYEKAGVSTDTAFTFSIIQYCLGIAATFISWWASKYCGRFDLYAFGLAFQAIMFFIIGGLGCSDTHGAKMGSGALLMVVAFFYNLGIAPVVFCLVSEIPSSRLRTKTIILARNAYNVIQVVVTVLIMYQLNSEKWNWGAKSGFFWGGFCLATLAWAVVDLPETAGRTFIEINELFRLGVPARKFKSTKVDPFAAAKAAAAEINVKDPKEDLETSVVDEGRNTSSVVNK
Protein: 26.7 kDa heat shock protein, chloroplastic (OsHsp26.7) (Q10P60)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Os06g0592500 protein
Sequence:
MAAPFALVSRVSPAARLPIRAAWRRARPTVGLPSSGRARQLAVASAAQENRDNTAVDVHVNQDGGNQQGNAVQRRPRRSSALDGISPFGLVDPMSPMRTMRQMLDTMDRIFDDVALGFPATPRRSLATGEVRMPWDVMEDDKEVRMRFDMPGLSREEVKVMVEDDALVIRGEHKKEEGEGAEGSGDGWWKERSVSSYDMRLALPDECDKSKVRAELKNGVLLVTVPKTEVERKVIDVQVQ
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Q583H3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Probable 26S proteasome regulatory subunit rpn-6.2
- 26S proteasome regulatory non-ATPase subunit
- 26S proteasome regulatory subunit 4 homolog
- Proteasome regulatory ATPase subunit 6
- Proteasome regulatory non-ATPase subunit 8
- Proteasome regulatory ATPase subunit 1
- Proteasome regulatory non-ATP-ase subunit 9
- Proteasome regulatory non-ATP-ase subunit 10
- Proteasome regulatory ATPase subunit 3
- Proteasome regulatory non-ATP-ase subunit 5
Sequence:
MVPVKVKWGRETFELTVDLRSTVKCFKEQLQQLTSVPVERQKIMGVKASQCNDNEVTLEAAGVAAGKTLMLIGTAAEVVRATPIVATGNKDSAVQAPASHPAEKQAVGLQNIANTCYMNAAVQMLRLVPEVRDVLNFNANDPIVSELLKLYNTMDTKRDPVVPASLWSILLAHFPTFAEVNEKGHPMQHDSQEALNALLQRINSCLPESHKRLFTGNLSQKMVCKDDPDDQPVLHDVPFLMLSCNIDAEIETLEAGLEAAFNETVKLHSEKLAREALHTRTSRIAAMPEYLFIHMVRFSWRSDIQSKAKILKPVTFPMTLDLHALCAEEYKPELEVERKRVLKRRDIEMERRRAAKNKTKLDDDEAAPAEDASNTAEPINTTVGNHSGYYELCGVISHKGRSADSGHYVFWGKYADQWMVLDDSNTAAVSEEDVKRLRGSGEAHIAYVLMYRSRDPRTKQSVIPL
Protein: Transcription elongation factor SPT6 (Protein pandora) (Q8UVK2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription elongation factor which binds histone H3 and enhances transcription elongation by RNA polymerase II (RNAPII). Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. Plays an important role during early patterning and somitogenesis of the embryo.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- TFIIS N-terminal domain-containing protein.
- Transcription elongation factor SPT5
- RNA polymerase-associated protein LEO1
- DNA-directed RNA polymerase subunit
- FACT complex subunit
- RNA polymerase-associated protein CTR9 homolog
- RTF1 homolog, Paf1/RNA polymerase II complex component.
- Transcription elongation factor SPT4
- Parafibromin
- FACT complex subunit SSRP1
Sequence:
MSDFIESEAEESEEEFEEKDLKPKKTQRFMEEDEEEEEENTEDQDEHGNLRGLIDDDDVEEEEEEERGEPPAGEDSDSGEEVRHRRRKRSFDDYLDDDDLDLIEENLGVKVKRRKKKYSRVKTMDDEGDDDDEKDLIADEIFTGDGDGEGEVEDGEAVDTLHPRDDEEEEDDEESDIDDFIVDDDGQPITKKKGKKFSGYTDAALQEAQEIFGGDFDFAEFDTEAYDHAEEEEEDQDDESWDRPKKQTKRRVSRRSIFEIYEPSELESSHMTDQDNEIRSTDMPERFQLRAIPVKPAEDDELEEEAEWIYRNAFSTPTISMQESTDYLDRGTTTNFSRKGPSTIAKIKEALNFMRNQHFEVPFIAFYRKEYVEPELNINDLWKVWQWDEKWTQLKTRKQNLTRLFQRMQSYQFEQISADPDKPLADSTRPLDTADMERLKDVQSIDELGDVYNHFLLYYGRDIPKMQNAAKGGKKKLKKIKEVSEEDGEEAEVEEEEEEEEQKGPDLKQASRRDMYSICQSAGLDGLAKKFGLTPEQFGENLRDSYQRHETEQFPAEPLELAKDYVCSQFNTPEAVLEGARYMVAMQIAREPLVRHVLRQTFQERAKINIKPTKKGKKDVDEAHFAYSFKYLKNKPVKELSGDQFLKMCLAEEEGLLAIDICIDLVGVKGYGDQTYFDEIKQFYYRDEFSHQVQEWNKQRTLAIERSLQQFLYPQMAKELKNKLIAEAKDNIVKSCCKKLYNWLKVAPYRPDQQVEEDDDLMDESQGKGIRVLGVAFASGRDTPVFCSLINGEGEVVDFLRLPYFLKRRNAWREDEREKKQQDVENLKKFLLSKKPHVVAVSGENRDAHMVMEDIKRTISELEQNSSLPVVGVELVDNELAVLYMNSKKSEADFRDYPPLLRQAVSVARKIQDPLVEFAQVCSTDDDILCLKLHPLQEHVVKEELLSALYCEFINRVNEVGVDVNRAIAHPYTQSLVQYICGLGPRKGSHLLKILKQNNTRLENRTQLVTMCHMGPKVFINCAGFIKIDTASLGDSTDSYIEVLDGSRVHPETYEWARKMAVDALEYDESAEDANPAGALEEILENPERLKDLDLDAFAEELERQGYGNKGITLYDIRAELSCRYKDLRAPYRPPNTEEVFNMLTKETPETFYIGKLITCVVTNIAHRRPQGESYDQAIRNDETGLWQCPFCQQDNFPELSEVWNHFDSGSCPGQAIGVRTRLDNAVMGFIPTKFLSDKVVKHPEERVKPGMTVHCRIMKIDIEKFNVDLTCRTSDLSDKNNEWKLPKDTYYDFDAETDDVKQEEEQKKKQQRTTYIKRVIAHPSFHNINFKQAEKMMESMDQGDVVIRPSSKGENHLTVTWKVADGIYQHVDVREEGKENAFSLGHTLWINTEEFEDLDEITARYVQPMAAFARDLLGHKYFHECNGGDRKKMEELLVRTKKEKPTFIPYYISACRDLPGKFLLGYQPRGKPRIEYVTITPDGFRYRSQIFPTVNGLFRWFKDHYQDPVPGVTPASSRTRTPASVNATPANINIADLTRAVNSLPRNMTSQMFNAIAAVTGQGQNPNTTPAQWASSQYGYSGGSSAGGGGGSSSAYHVFATPQQPMATPLMTPSYSYTTPGQQQAMTTPQYPSSTPQSSHGHHQHSSSTPSSSSSRVRTPQPKASSHTAVDWGKMAEQWLQEKEAERRKQKTPRMTPRPSPSPMIESTPMSIAGDATPLLDEMDR
Protein: Hepatocyte nuclear factor 3-gamma (HNF-3-gamma) (HNF-3G) (Forkhead box protein A3) (P35584)
Organism: Mus musculus (Mouse)
Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates GLUT2 transcription. Involved in regulation of neuronal-specific transcription. Involved in regulation of spermatogenesis; required for the maintenance of the testicular germ cell population and male fertility.
Subcellular location: Nucleus.
Interaction partners:
- Hepatocyte nuclear factor 4-alpha
- Hematopoietically-expressed homeobox protein Hhex
- Hepatocyte nuclear factor 1-alpha
Sequence:
MLGSVKMEAHDLAEWSYYPEAGEVYSPVNPVPTMAPLNSYMTLNPLSSPYPPGGLQASPLPTGPLAPPAPTAPLGPTFPSLGTGGSTGGSASGYVAPGPGLVHGKEMAKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKAKKGNSATSASRNGTAGSATSATTTAATAVTSPAQPQPTPSEPEAQSGDDVGGLDCASPPSSTPYFSGLELPGELKLDAPYNFNHPFSINNLMSEQTSTPSKLDVGFGGYGAESGEPGVYYQSLYSRSLLNAS
Protein: Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6) (GABAAR subunit alpha-6) (P30191)
Organism: Rattus norvegicus (Rat)
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000255}. Note=Present in Golgi synapses, on the extrasynaptic membranes, and in some of the mossy fiber to granule cell synapses (PubMed:9464994). Also found on the extrasynaptic somatic and dendritic membranes (PubMed:9464994). {ECO:0000269|PubMed:9464994}.
Interaction partners:
- Huntingtin-associated protein 1
- Inactive phospholipase C-like protein 1
- Trafficking kinesin-binding protein 2
- Basic helix-loop-helix family, member e23
- Vesicle-fusing ATPase
- Integrin beta-1
- Cerebellin 3 precursor
- Neuronal acetylcholine receptor subunit alpha-3
- Integrin beta-4
- Integrin alpha-6
Sequence:
MLLLLPWLFSLLWIENAQAQLEDEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFKGPAEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMHNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQKAERQAQTAAKPPVAKSKTTESLEAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKVLSRTPILPSTPVTPPLLLPAIGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE
Protein: Cysteine protease ATG4b (EC 3.4.22.-) (Autophagy-related protein 4 homolog b) (AtAPG4b) (Protein autophagy 4b) (Q9M1Y0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. In addition to the protease activity, also mediates delipidation of PE-conjugated ATG8 proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8BGE6}.
Interaction partners:
- Autophagy-related protein 8a
- Autophagy-related protein 8d
- Autophagy-related protein 8b
- Autophagy-related protein 8g
- Autophagy-related protein 8i
- Autophagy-related protein 8f
- Autophagy-related protein 8e
- Autophagy-related protein 8h
- Autophagy-related protein 8c
- Autophagy-related protein 3
Sequence:
MKAICDRFVPSKCSSSSTSEKRDISSPTSLVSDSASSDNKSNLTLCSDVVASSSPVSQLCREASTSGHNPVCTTHSSWTVILKTASMASGAIRRFQDRVLGPSRTGISSSTSEIWLLGVCYKISEGESSEEADAGRVLAAFRQDFSSLILMTYRRGFEPIGDTTYTSDVNWGCMLRSGQMLFAQALLFQRLGRSWRKKDSEPADEKYLEILELFGDTEASAFSIHNLILAGESYGLAAGSWVGPYAVCRSWESLARKNKEETDDKHKSFSMAVHIVSGSEDGERGGAPILCIEDVTKTCLEFSEGETEWPPILLLVPLVLGLDRVNPRYIPSLIATFTFPQSLGILGGKPGASTYIVGVQEDKGFYLDPHDVQQVVTVKKENQDVDTSSYHCNTLRYVPLESLDPSLALGFYCQHKDDFDDFCIRATKLAGDSNGAPLFTVTQSHRRNDCGIAETSSSTETSTEISGEEHEDDWQLL