wanglab/gogpt-training-data huggingface dataset:
Protein: Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) (Q8K400)
Organism: Mus musculus (Mouse)
Function: Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release (By similarity). Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12832401}. Cell membrane {ECO:0000269|PubMed:12832401}; Peripheral membrane protein {ECO:0000269|PubMed:12832401}. Membrane {ECO:0000269|PubMed:12832401}; Peripheral membrane protein {ECO:0000269|PubMed:12832401}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane.
Interaction partners:
- Synaptosomal-associated protein 25
- Synaptosomal-associated protein 23
- Syntaxin-11
- Neuronal acetylcholine receptor subunit alpha-4
- Neuronal acetylcholine receptor subunit beta-2
- Acetylcholine receptor subunit beta
- Acetylcholine receptor subunit gamma
- Neuronal acetylcholine receptor subunit alpha-6
- Acetylcholine receptor subunit delta
- Syntaxin-4
Sequence:
MRKFNIRKVLDGLTAGSSSASQQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAVLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKAHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVELKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRQNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVLTEVIPMLEVRLLYEINDVDTPEGEQPPPLSTPVGSSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLALNSSYGLVVFGNCNGIAMVDYLQKAVLLNLSTIELYGSNDPYRREPRSPRKSRQPSGAGLCDITEGTVVPEDRCKSPTSGSSSPHNSDDEQKVNNFIEKVKTQSRKFSKMVANDLAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESRETISALHFCETLTRKADSSPSPCLWVGTTVGTAFVITLNLPPGPEQRLLQPVIVSPSGTILRLKGAILRMAFLDATGCLMSPAYEPWKEHNVAEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVMSLPTQSCAYKQNITETSFVLRGDIVALSNSVCLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLSDLEERTAAMMSSADSFSKHAHEMMLKYKDKKWYQF
Protein: F-box protein At4g35930 (Q5XF11)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- AT3g54190/F24B22_150
- Transducin/WD40 repeat-like superfamily protein
Sequence:
MGKVSPKDLDSKTSVRKKKLKSSSNKYLKPGALVQLCYSKASAAKSCNELGKKRVPVFDTKSCNDLGKKRVPVFDIKHARNNKMAVEQLNSPKSPLMLSPVNVVKRSTLVRPMKFDDLQVESNNTCKKSPLMLSPMGIVMQNTLLRTPKTPQADPCVSESQLESLPMDLLVKIVCHLHHDQLKAVFHVSQRIRMATILARQYHFNYTTPDRSRQEMLRVMTPVPINRWPFRRGDGNPTMVSSPHTPKAPKHAPRPPSRTKLAEMKQITAVLFQDQTPFPSRCIVPSVLQRPTLFKPMAPKHPRVLFYEDELCQAVAQNNLT
Protein: Novel plant SNARE 11 (AtNPSN11) (Q944A9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: t-SNARE involved in diverse vesicle trafficking and membrane fusion processes, including cell plate formation.
Subcellular location: Membrane; Single-pass type IV membrane protein. Note=Cell plate during cell division.
Interaction partners:
- Syntaxin-71
- Syntaxin-related protein KNOLLE
- Vesicle-associated membrane protein 721
- Vesicle-associated membrane protein 722
- Syntaxin-132
- Syntaxin-73
- Syntaxin-72
- SNAP25 homologous protein SNAP33
- Syntaxin-21
- Vesicle transport v-SNARE 12
Sequence:
MDPISAVSEELAEIEGQINDIFRALSNGFQKLEKIKDANRQSRQLEELTDKMRDCKSLIKDFDREIKSLESGNDASTNRMLNDRRQSMVKELNSYVALKKKYSSNLASNNKRVDLFDGPGEEHMEENVLLASNMSNQELMDKGNSMMDDTDQAIERGKKIVQETINVGTDTSAALKAQTEQMSRVVNELDSIHFSLKKASKLVKEIGRQVATDKCIMAFLFLIVIGVIAIIIVKIVNPNNKDIRDIPGVGLAPPAMNRRLLWNHY
Protein: NAC domain-containing protein 83 (ANAC083) (Protein VND-INTERACTING 2) (Q9FY93)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor that negatively regulates the expression of genes involved in xylem vessel formation. Represses the transcriptional activation activity of NAC030/VND7, which regulates protoxylem vessel differentiation by promoting immature xylem vessel-specific genes expression. Transcriptional activator that regulates the COLD-REGULATED (COR15A and COR15B) and RESPONSIVE TO DEHYDRATION (LTI78/RD29A and LTI65/RD29B) genes by binding directly to their promoters. Mediates signaling crosstalk between salt stress response and leaf aging process. May play a role in DNA replication of mungbean yellow mosaic virus.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:21673078}.
Interaction partners:
- NAC domain-containing protein 30
- Transcription factor MYB46
- Transcription factor MYB83
Sequence:
MDNVKLVKNGVLRLPPGFRFHPTDEELVVQYLKRKVCSSPLPASIIPEFDVCRADPWDLPGNLEKERYFFSTREAKYPNGNRSNRATGSGYWKATGIDKRVVTSRGNQIVGLKKTLVFYKGKPPHGSRTDWIMHEYRLSSSPPSSMGPTQNWVLCRIFLKKRAGNKNDDDDGDSRNLRHNNNNNSSDQIEIITTDQTDDKTKPIFFDFMRKERTTDLNLLPSSPSSDHASSGVTTEIFSSSDEETSSCNSFR
Protein: Uncharacterized protein (Q9U6W3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
TVIGRAASLYTDPFLLFSGMLTSYSLFGRLMKQQPIRLKNEYISRLMRIVPPLAALILFCTYVLPLWGSGPQWNLVVGHHADICKKNWWRNLLFIHNYFGFSEMCLTHTHHLGIDTELFAVAPLLILALWRGQDVASSPCCCSARIQRLFRTADYMYSFPPHRSTVYIMGILLGYVLRKYQNARLSSLQLRLGWLVATVCVLASLLGPAPMGDINYVYNSTHAAIYAAFAPIAWCLFFSWIVFVSHNGYTNKLTKLFAWRGFQVSTKLSYAIYLTQFPVFFFNVGRRRHIHHYYNFVSIILDTNEFISIFLASVALTVFFDAPFQNLKKLLIKRPTAAKVVKDSKAKAAESQDATTTTLASQPSSTALLQSHHPHSD
Protein: Cystatin-A3 (VSA745) (Q5R1U3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Intracellular thiol proteinase inhibitor.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MTGGISPHPINATPEIQEITNTVKEQLEKKLGTNYSIFQAISYKKQLVNGMNYFIKVKTDNGYDHIRVYEAFKGTPNLVSVQQHKSLEDDITYF
Protein: NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) (Human epididymis-specific protein 1) (He1) (Niemann-Pick disease type C2 protein) (P61916)
Organism: Homo sapiens (Human)
Function: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:11125141, ECO:0000269|PubMed:15937921, ECO:0000269|PubMed:19723497, ECO:0000269|PubMed:21315718}. Endoplasmic reticulum {ECO:0000269|PubMed:19723497}. Lysosome {ECO:0000269|PubMed:15937921, ECO:0000269|PubMed:19723497, ECO:0000305|PubMed:11125141}. Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes. {ECO:0000305|PubMed:11125141}.
Interaction partners:
- NPC intracellular cholesterol transporter 1
- StAR-related lipid transfer protein 3
- STARD3 N-terminal-like protein
- NPC1-like intracellular cholesterol transporter 1
- Ganglioside GM2 activator
- Apolipoprotein B-100
- Acyl-coenzyme A diphosphatase NUDT19
- Sterol regulatory element-binding protein cleavage-activating protein
- Lysosomal acid lipase/cholesteryl ester hydrolase
Sequence:
MRFLAATFLLLALSTAAQAEPVQFKDCGSVDGVIKEVNVSPCPTQPCQLSKGQSYSVNVTFTSNIQSKSSKAVVHGILMGVPVPFPIPEPDGCKSGINCPIQKDKTYSYLNKLPVKSEYPSIKLVVEWQLQDDKNQSLFCWEIPVQIVSHL
Protein: Palmitoleoyl-protein carboxylesterase notum1a (EC 3.1.1.98) (C5H5C4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway. Acts by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9VUX3}.
Interaction partners:
- Carboxylesterase notum2
- Protein Wnt-1
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Uncharacterized protein LOC436988
- Uncharacterized protein.
- Leucine-rich repeat-containing 18b
- Protein Wnt-8a
Sequence:
MKRSLWVMQVLHWAVMLALVQCGALGARRFRGGRNPQPRRALPSAHYRDRGETTESFSLDFTAVEENMDNFMTQVKNLAQSLYPCSAQKLDYDMKLHFLENTSVTCNDGTPAGYYLKESKGSKRWLIFLEGGWYCFNKENCDSRYETMRRLMSSSKWPQTKTGTGMLSSLPEENPHWWNANMVFIPYCSSDVWSGASPKTDQNDYAFMGSLIIKEVVKDLLSKGLDNAKILLLAGSSAGGTGVLLNVDSVSELLEELGHTNIQVRGLSDSGWFLDNKQYRCTDCVDTINCAPTEVIKRGIKYWGGVVPERCRQAYEGKEWNCFFGYKVYPTIKRPVFIVQWLFDEAQLTVDNIHLTGQPVQEGQWRYIQNLGTELRNTLKDVPAMFAPACLSHEFITRNYWTDVQVKGTSLPRALHCWDRSLQDTSRNNKSPPKGCPVHLIDSCPWPHCNPTCPTIRDQSTGQEMNVIQFLMHMGFDVQKMAHQQGMDPSKLLGMLSSGS
Protein: Putative receptor protein kinase CRINKLY4 (EC 2.7.11.1) (O24585)
Organism: Zea mays (Maize)
Function: Putative receptor protein kinase. Could play a role in a differentiation signal. The CRINKLY4 (CR4) mutation affects leaf epidermis differentiation such that cell size and morphology are altered, and surface functions are compromised, allowing graft-like fusions between organs.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome, multivesicular body membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Also localized into protein export bodies. {ECO:0000250}.
Interaction partners:
- Calpain-type cysteine protease DEK1
- Superal1
- Non-structural maintenance of chromosomes element 1 homolog
- Non-structural maintenance of chromosomes element 1 homolog
- Non-structural maintenance of chromosomes element 1 homolog
- DNA mismatch repair protein MSH4
- Telomerase reverse transcriptase
Sequence:
MDHVPALVLAGCCFLALLPGWACGLGSMSSIAVSYGEDGPVFCGLNSDGSHLVACFGADASVLYGAPPNIPFLGLTAGDGFVCGLLLDTRQPYCWGSNSYVKSGVPQPMVEGARYSELSAGDNHLCALRAAQDGGRGSSAATSLIDCWGYNMTATHAVDEAVSTVSAGSVFNCGLFARNRTVFCWGDETVSGVVGLAPRDLHFQSIGAGGYHVCGVLENAQVFCWGRSLEMQQVVPSSAIGDGDVNIVPMDAMSTVVGGRFHACGIRSLDHQVACWGFTLHNSTSPPKGLKMYALVAGDYFTCGVPAETSLMPRCWGNSGPLALPMAVPPGICVPTACSHGYYEYVNHGEVGSIKVCKPANSRLCLPCSTGCPEGLYESSPCNATADRVCQFDCLKCVTDECLSFCLSQKRTKSRKLMAFQMRIFVAEIVFAVVLVLSVSVTTCLYVRHKLRHCQCSNRELRLAKSTAYSFRKDNMKIQPDMEDLKIRRAQEFSYEELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSILGPADSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQFEEGNIVEWAVPLIKAGDIFAILDPVLSPPSDLEALKKIASVACKCVRMRGKDRPSMDKVTTALEHALALLMGSPCIEQPILPTEVVLGSSRMHKVSQMSSNHSCSENELADGEDQGIGYRAPSWITFPSVTSSQRRKSSASEADIVGRRATDGRNVGSSIGDGLRSLEEEIAPASPQENLYLQHNF
Protein: Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) (P05026)
Organism: Homo sapiens (Human)
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:34011520}; Single-pass type II membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P07340}; Single-pass type II membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000250|UniProtKB:P14094}.
Interaction partners:
- Sodium/potassium-transporting ATPase subunit gamma
- Sodium/potassium-transporting ATPase subunit alpha-1
- Sodium/potassium-transporting ATPase subunit alpha-3
- Sodium/potassium-transporting ATPase subunit alpha-2
- Sodium/potassium-transporting ATPase subunit alpha-4
- Sodium/potassium-transporting ATPase subunit beta-2
- Potassium-transporting ATPase alpha chain 2
- Sodium/potassium-transporting ATPase subunit beta-3
- Phospholemman
- Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
Sequence:
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS
Protein: At1g56300 (Chaperone DnaJ-domain superfamily protein) (DnaJ protein, putative) (Q8L7R1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Uncharacterized protein At5g65300
- Alpha/beta-Hydrolases superfamily protein
- Succinate-semialdehyde dehydrogenase, mitochondrial
- Uncharacterized protein At2g23090
- Mitochondrial import inner membrane translocase subunit TIM17-1
- ACD11 homolog protein
- Heat shock 70 kDa protein 17
- Chaperone protein ClpB4, mitochondrial
- Heat shock protein 90-3
- Zinc finger A20 and AN1 domain-containing stress-associated protein 3
Sequence:
MACEGGGSNVRSSYYTILGIRKDASVSDIRTAYRKLAMKWHPDRYARNPGVAGEAKRRFQQIQEAYSVLNDENKRSMYDVGLYDPHEDDDDDFCDFMQEMISMMNNVKDAGESLEDLQRMFTDMVGGDGVSYDCNNNPKGNKRPRVNISRSSAAMR
Protein: Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) (P25961)
Organism: Rattus norvegicus (Rat)
Function: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1313566}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Parathyroid hormone
- Tuberoinfundibular peptide of 39 residues
- Beta-arrestin-2
- Beta-arrestin-1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-13
- Low-density lipoprotein receptor-related protein
Sequence:
MGAARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKASGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLPPATTNGHSQLPGHAKPGAPATETETLPVTMAVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (A0A8I5ZW61)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MLMTVMHHALSFFLGLVEGAMDLILINSLPLVSDAETSLTCIASGWHPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPDCNRPCTTCKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGSEGCKSYVFCLPDPYGCSCATGWRGLQCNEACPYGHYGPDCKLRCHCTNEEMCDRFQGCLCSQGWQGLQCEKEGRPRMTPQIEDLPDHIEVNSGKFNPICKASGWPLPTSEEMTLVKPDGTVLQPNDFNHTDHFSVAIFTVNRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIQVMNEIVTLNYLEPRTDYELCVQLVRPGEGGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTSSEDEFYVEVERWSQQTRSDQQNIKVPGNLTSVLLNNLLPREQYSVRARVNTKAQGEWSEELRAWTLSDILPPQPENIKITNITDYTALVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATITQYQLKGLEPETTYHVDIFAENNIGSSNPAFSQEIRTLPAPKDLGGGKMLLIAILGSAGMTCITVLLAFLIMLQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKAKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDETLPSVSVGLTDSTSCVPGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
Protein: Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll) (Q9Y466)
Organism: Homo sapiens (Human)
Function: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Lysine-specific histone demethylase 1A FAD-dependent demethylase 1A)
- Histone deacetylase 5
- Atrophin-1
- G-protein coupled receptor 6
- Glutamate receptor ionotropic, kainate 5
- Histone deacetylase 2
- Histone deacetylase 7
- REST corepressor 1
- Histone deacetylase 1
- Nestin
Sequence:
MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
Protein: Small ribosomal subunit protein eS10 (40S ribosomal protein S10) (F6U211)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFVLIAHDCSQIMSFVKRKHVQ
Protein: At2g44720/F16B22.21 (RNA-binding (RRM/RBD/RNP motifs) family protein) (Q8RWQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein trichome birefringence-like 11
- BTB/POZ domain-containing protein At4g01160
- Flavin-containing monooxygenase FMO GS-OX-like 7
- Diacylglycerol kinase 4
- E3 ubiquitin-protein ligase RKP
Sequence:
MPPKVVKRGGAARRGGRLTRSALKAQNPHVESSHDESVNIGELSGSDALEAKEVTPEVDKTVEEENPLDVPKSSDSIDDSEAAANPHVDVPSKKETEVEESVDDFGKDERLDLDDNEPEYEAEEYGGEEFEERELGQEDHELVNEEGEELEEEIEVEEEAGEFADEIGDGAEDLDSEDDDDDHAIEEVKHGETVDVEEEEHHDVLHERRKRKEFEIFVGSLDKGASEEDLKKVFGHVGEVTEVRILKNPQTKKSKGSAFLRFATVEQAKRAVKELKSPMINGKKCGVTASQDNDTLFVGNICKIWTPEALREKLKHYGVENMDDITLVEDSNNVNMNRGYAFLEFSSRSDAMDAHKRLVKKDVMFGVEKPAKVSFTDSFLDLEDEIMAQVKTIFIDGLLPSWNEERVRDLLKPYGKLEKVELARNMPSARRKDFGFVTFDTHEAAVSCAKFINNSELGEGEDKAKVRARLSRPLQKAGKGRQSSRSDQRSRHGAGRSGRSSFARLPPRSLASSRSARGAGSRAPSSSAKRASGSRGRRPRPPLPPPARARPLPPPARARPMPPPARARPLPPPARSYDRRPPVPLYPKASLKRDYDRRDELPPPRSRPAVSYSSRLSPERHLSYRDDYPPRGSGYSDLPRSSSRSEIRRPFVDDLYSPRFERPPSYSEGRPRAYEPLPGSKRPYAALDDLPPRYADVDVRHSRPRLDYDVGPSQYGESYGDRIPRSSLGYGSSRNSMSNHDSRGPYSSRQGMDYGGGSYSGSDVGGMYSSSYGGDLPRRDGGGSSYSSIYSSRGLGGSSYSGGGPGSYY
Protein: 1-aminocyclopropane-1-carboxylate synthase (ACC synthase) (EC 1.4.-.-) (EC 4.4.1.14) (S-adenosyl-L-methionine methylthioadenosine-lyase) (P37821)
Organism: Malus domestica (Apple) (Pyrus malus)
Function: Catalyzes the formation of 1-aminocyclopropane-1-carboxylate, a direct precursor of ethylene in higher plants. Catalyzes also the conversion of L-vinylglycine (L-VG) to alpha-ketobutyrate and ammonia. Can use S-methylmethionine as substrate.
Interaction partners:
Sequence:
MRMLSRNATFNSHGQDSSYFLGWQEYEKNPYHEVHNTNGIIQMGLAENQLCFDLLESWLAKNPEAAAFKKNGESIFAELALFQDYHGLPAFKKAMVDFMAEIRGNKVTFDPNHLVLTAGATSANETFIFCLADPGEAVLIPTPYYPGFDRDLKWRTGVEIVPIHCTSSNGFQITETALEEAYQEAEKRNLRVKGVLVTNPSNPLGTTMTRNELYLLLSFVEDKGIHLISDEIYSGTAFSSPSFISVMEVLKDRNCDENSEVWQRVHVVYSLSKDLGLPGFRVGAIYSNDDMVVAAATKMSSFGLVSSQTQHLLSAMLSDKKLTKNYIAENHKRLKQRQKKLVSGLQKSGISCLNGNAGLFCWVDMRHLLRSNTFEAEMELWKKIVYEVHLNISPGSSCHCTEPGWFRVCFANLPERTLDLAMQRLKAFVGEYYNVPEVNGGSQSSHLSHSRRQSLTKWVSRLSFDDRGPIPGR
Protein: Ectodysplasin-A (EDA protein homolog) (Tabby protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form] (O54693)
Organism: Mus musculus (Mouse)
Function: Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor EDA2R (By similarity). May also play a role in cell adhesion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10534613}; Single-pass type II membrane protein {ECO:0000269|PubMed:10534613}.; SUBCELLULAR LOCATION: [Ectodysplasin-A, secreted form]: Secreted {ECO:0000250|UniProtKB:Q92838}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member EDAR
- Tumor necrosis factor receptor superfamily member 27
- Ectodysplasin-A receptor-associated adapter protein
Sequence:
MGYPEVERREPLPAAAPRERGSQGCGCRGAPARAGEGNSCRLFLGFFGLSLALHLLTLCCYLELRSELRRERGTESRLGGPGAPGTSGTLSSPGSLDPVGPITRHLGQPSFQQQPLEPGEDPLPPDSQDRHQMALLNFFFPDEKAYSEEESRRVRRNKRSKSGEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKTGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS
Protein: Phosphoinositide 3-kinase (Q9VTN5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSNQAHIDYDKQFQDDLAKATALSLEQHALDDYRRNKKYGSGYQQSSTVAGRDYQAAQRSQSLHQPRRHSEVHQVAISPENAERSRTPPAQGTDNDLICFASPTSKQPESSSPFGKLIEDLQRMQPTNPQSALVPMGPVASASIPPQYGFPPHQQRPTAAQPTPYGMVAGGVVGGPAYGDLQLVPYQPAAQQQRPLNSEELQRLYSMPAQMAVVPVPQPNAYMYYPGAVVTPYTAPIVPGSAAFMPPQYPAQGYGFGGAYTHMDLRRPQSQPAPQQTAPTTSHHHSQPSNHSTSSTAEANGVAFPARRQVPSTVGVSSSSHTGNNGHSSVPPRGNDLIDLNHEDYSRVSVLEAFDPLLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNVGLIGWRQDFLSQPSTSSSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHDDAPTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSNVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQALASLEGQVKGTVTDYAVKPIGLLEWLAPTLRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIARTERDDEHDADLLPEHLLPNEVVQIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIVVCISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLTFDQHPICTLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYLLSLWPPMTDKMLGPAPARGCHPQPDFCPVLSIEVPPYGGRIEFPEHQEVPKPAPHYDFASLDANLQEELLDTAELGYTGATERREVFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNSNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGELLSFVPRKYTMQQDGRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPLVKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLGMPKIKEVKQQPSRDNPHEIGQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDPKKETKRKTKVVRKTCVPSFMETLEYRMPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYDLRQELVDWYRLGAVSRN