wanglab/gogpt-training-data huggingface dataset:
Protein: Integrin alpha-3b isoform X2 (Integrin, alpha 3b) (F1R2R3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Interaction partners:
- Integrin beta
- Integrin beta
- Laminin, alpha 5.
- Reelin domain-containing protein.
- Integrin, alpha 3a
- Fibronectin
- Integrin beta
- Integrin beta
- Integrin beta.
- Laminin, alpha 4.
Sequence:
MAGKSLHLCVFVICAIQTNTGFNIDVQFPVIKEGKTKGSLFGFSVALHKQTEKAKKNLLLVGAPQEKAHPQLSKFKINETGAVYYCPITVNQDDCGSMDLISPPKSTDMLEGMWLGVTVASQRNGGRVLACGHRYVKKLLGAEEQQRMVGKCYVRGNDLSYDPSDYWQSETYELCDFNHDQDLEGMCNMGISGGMTEKDVYFGTPGSFTWQGTVHMKCRDTDSDYAGDANDRSFGKLGEDKFNIYIGYSVLEDIKLLDRSVFTVVMGAPRDEFKGSVILADKQDLILKQLMTITGEQIGSYFGSCLAVTDLNNDDWNDLIVGAPFYFDRYKEEGGAVYIFMNENGSFQKKASLVLKGKKGSGFGFAVAAVGDVNQDGFQDIAVGAPFQDSGKVYIWMGSKSGITKEPSQVIEGKSLGPSGFQTFGYSLSGGMDMDGNDYPDILVGSLDDRIALLRSRPVIHLSKNFTVEPKIVIPSQCGISCIKVKVCFSYTLSNGNSNFRKEITVKFTIDADQNRRGARVRFIDNKQSTFTGLLSFSASSCQELELSVNNPVTDKLQPIVFSLNVSLNQQKAAAQQTLQSLDSFPVLSGQQILTDKAEINFHKECGDDNRCSSNLQLKARFADENYNPFPSQTLEFSSNVKKLVLMVEVSNTADENKPAEDAHQATLNISIPYSLKYSGVRPPAGFDMECSADEAVICDLGNPFKSNQKVSFIIIFETSGITLYTEQIQSQLQLSTISEQADLFPVLVTLNVKNTILTTFSLEKLIIDTSFSGNVIGESAMSSTSDVGSPLEFVFRVQVLGEPLGDLGTLVIDFDWPYAVANGKWLLYLTEIVIKGSSESHCVPPGNIVNYLNLTLSKEGTKRNKREVDSGFPHAEASVTVLATRKVAHFLDCSKKTALCQTFSCPLLNMSTQAEVRVRARVWNGTLLEDYAKALRVEVKGQATLRLLTDKPAIKMDNQTREFSVNIDPVLGEETPYEVPLWIIIVAAVAGILLLGIISLILWKCGFFRRASRREMYEAKSQKAEIKIQPSETERLTEEF
Protein: Maturase (A1XJ11)
Organism: Oryza sativa (Rice)
Interaction partners:
Sequence:
IRMVLESIYDPEFPDTSHFRSGRGCHSALRRIKEEWGTSRWFLEFDIRKCFHTIDRHRFISILKEEIDDSKFFYPTQKQFSAGRLVGGEKGPDSVPNSVLLSALLGNIYLHKLDQEIGRIRQKHEIPLVVKIRSVLLRIGRRIDDQEKYGKEAGFNAPQDNRALIVGRVKSIQRKATFHSLVSSWHTPPTSTPRRRGDQKTPFVFPPSAALAAFLNKPSSLLCAAFLIEAAGLTPRAEFNGREGFNKNLAMRDLLKYCKRRGLLIELGGEAILVIRSERGLARKLAPFKSHSLLIRICYARYADDLLLGIVGAVFLLIEIQKRITHFLQSGLNLWVGSAESTTIAARSTVEFLGTVIREVPPRTTPIQFLRELEKRLRVKHRIHITACHLRSAIHSKFRDLGYSIPIKELTKGMSGRGRLLDAVQLAETLGKNGLKSPQVSVLWGTVKHIRQRFRGIPLLHSSGQSKVPSGVQQAVSRSGMSVLKTKLYTPFGRKAAGEGRGHWAGSFSSEFPIQIEAPIKKILRRLRDRGLISRRRPRPIHVASLTNVSDRDIVNWSAGIAISPLSYYRCCDNLYQVRTIVNYQIRWSAIFTPAHKH
Protein: Transcription factor bHLH96 (Basic helix-loop-helix protein 96) (AtbHLH96) (bHLH 96) (Transcription factor EN 15) (bHLH transcription factor bHLH096) (Q9C7T4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Protein RADIALIS-like 6
Sequence:
MALEAVVYPQDPFSYISCKDFPFYDLYFQEEEDQDPQDTKNNIKLGQGQGHGFASNNYNGRTGDYSDDYNYNEEDLQWPRDLPYGSAVDTESQPPPSDVAAGGGRRKRRRTRSSKNKEEIENQRMTHIAVERNRRKQMNEYLAVLRSLMPPYYAQRGDQASIVGGAINYLKELEHHLQSMEPPVKTATEDTGAGHDQTKTTSASSSGPFSDFFAFPQYSNRPTSAAAAEGMAEIEVTMVESHASLKILAKKRPRQLLKLVSSIQSLRLTLLHLNVTTRDDSVLYSISVKVEEGSQLNTVEDIAAAVNQILRRIEEESSFS
Protein: Uncharacterized protein C10orf95 (Q9H7T3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MERSNAATKCGEEPRSGSRRLPKAEGDKSGSAGAPSKNSSRLGGRPCMCTAGRRPNRASGRRRRSCSPAPTWPPLCCYPQSRPTASAAGPGACMRASGRPHGNTTASTAPPRHPRPRRPGGPALRPTPRPCAGPAPPPASRDCRCRRPRRWPRAGRRGRRAGACKPSCAGAAWSARGAPLCSYRTSCAGSCGARTAPTPAPTCASPSAAASSCCRRRRACSSPTTAWSGACGAGPTAATAAQPGKPRSAAAPGRARA
Protein: Probable strigolactone esterase DAD2 (EC 3.1.-.-) (Protein DECREASED APICAL DOMINANCE 2) (J9U5U9)
Organism: Petunia hybrida (Petunia)
Function: Involved in strigolactone signaling pathway. May function downstream of strigolactone synthesis, as a component of hormone signaling or as an enzyme that participates in the conversion of strigolactones to the bioactive form. Can hydrolyze the synthetic strigolactone analog GR24 in vitro. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.
Interaction partners:
Sequence:
MGQTLLDALNVRVVGSGERVLVLAHGFGTDQSAWNRILPFFLRDYRVVLYDLVCAGSVNPDFFDFRRYTTLDPYVDDLLHILDALGIDCCAYVGHSVSAMIGILASIRRPELFSKLILIGASPRFLNDEDYHGGFEQGEIEKVFSAMEANYEAWVNGFAPLAVGADVPAAVREFSRTLFNMRPDITLFVSRTVFNSDMRGVLGLVKVPCHIFQTARDHSVPASVATYLKNHLGGKNTVHWLNIEGHLPHLSAPTLLAQELRRALSHR
Protein: Photosystem II reaction center protein J (PSII-J) (Q2LIK7)
Organism: Oryza officinalis
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01305}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01305}.
Interaction partners:
Sequence:
MADTTGRIPLWLIGTVTGIAVIGLIGVFFYGSYSGLGSSL
Protein: UDP-glucuronosyltransferase 1A3 (UGT1A3) (EC 2.4.1.17) (B3) (UDP-glucuronosyltransferase 1-3) (UDPGT 1-3) (UGT1*3) (UGT1-03) (UGT1.3) (Q64637)
Organism: Rattus norvegicus (Rat)
Function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P22309, ECO:0000250|UniProtKB:P35503}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGIQGFLQKLSGLLLLLCALPWAEGGKVLVFPMEGSHWLSIRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTLQTYPVPYTKEEYRHHLLGHLQNFFETEFSLKLVLQTMAAVNNVSTFYVRSCRGLLHNTALIQSLNSSSFDVVLTDPFFPCGAVLAMYLRVPAVFFLQSMLCELEFEATNSPNPSSYIPRLLTLNSDHMSFLDRVKNMLYPVPWMYLCHVNYGSLARLASDLLQREVSVVEILRHASVWLLRKDFVFHYPRPFMPNMVFIGGINCANRKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTLLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH
Protein: Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor) (Q9H0N5)
Organism: Homo sapiens (Human)
Function: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity).
Interaction partners:
- Phenylalanine-4-hydroxylase
- Tyrosine 3-monooxygenase
- Tryptophan 5-hydroxylase 1
- Tryptophan 5-hydroxylase 2
- Dihydropteridine reductase
- Pterin-4-alpha-carbinolamine dehydratase
- Hepatocyte nuclear factor 1-alpha
- Cation channel sperm-associated protein 3
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B
- Iodotyrosine deiodinase 1
Sequence:
MAAVLGALGATRRLLAALRGQSLGLAAMSSGTHRLTAEERNQAILDLKAAGWSELSERDAIYKEFSFHNFNQAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDCGELTKKDVKLAKFIEKAAASV
Protein: ER membrane protein complex subunit 1 (Q95TQ6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
Interaction partners:
Sequence:
MKGKAGDFTSFERDIASAFLRRITTQAVQIRSLFLHVIGLGPPPTDTQRAGLVRDSFGLHKMLVLLTRAGKIFGIDNVSGKHHWQLHLPNVIGFANDEQMRLIVQRSAKHFPLQPLCTILGKNAVSGNGVLYRFNPITGKVAEGGLVQLDYRIKQLSLLGETEKDFLKGILLLDASNKVHVYPEHAAPLADGMYLYTADLKTAELAGYFVKYAGGQLSSTHIWNARLGGHNSEQQIIGVAGKNPIEHVHSQGRVLGDRSVLYKYINPNLVAFVTQAPDSTHKSVLNLYLVDVVSGSVVFTMTHRKVRAPLSIVHSENWLAYSYFNEKLRRTEITTIELYEGKSQANSSVWSSLQAPPMPLVERQSYILPTIVEALRETITERGITNKHVLIGTASGSIVEMPWHLLDPRRPIASTTQGREEGAIPYIPELPLPTESHINYNQTVARLRNIYTAPSGLESTCLVVATGLDLFVTRVAPSKTFDLLKEDFDYILISIVLVALTSGSLIVKHLASRKLLKQAWK
Protein: Endo-1,4-beta-xylanase 6 (Xylanase 6) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase 6) (Q6QJ75)
Organism: Aspergillus niger
Function: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MKVTAAFAGLLVTALAAPAPEPVLVSRSAGINYVQNYNGNLGDFTYDESAGTFSMYWEDGVSSDFVVGLGWTTGSSNPITYSADYSASGSSSYLAVYGWDNYPQAEYYIVEDYGDYNPCSSATSLGTVYSDGSTYQVCTDTRTNEPSITGTSTFTQYFSVRESTRTSGTVTVANHFNFWAQHGFGNSDFNYQVVAVEAWSGAGSASVTISS
Protein: ABC-type antigen peptide transporter (EC 7.4.2.14) (Q5JNW1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL
Protein: Aminotransferase TOXF (EC 2.6.1.-) (TOX2 HC-toxin biosynthesis cluster protein TOXF) (Q9Y885)
Organism: Cochliobolus carbonum (Maize leaf spot fungus) (Bipolaris zeicola)
Function: Essential role in the production of HC-toxin and required for pathogenicity of the fungus on maize. May act on a precursor of 2-amino-9,10-epoxi-8-oxodecanoic acid. Acts on leucine, isoleucine and valine.
Interaction partners:
Sequence:
MAIPLPAFYKWDVYDSKLNNVHGHVECRYTAQTGYWSDPCFVQSPFLSVHGLAPGLNYGQQVYEGIQARRTARNEILIFRPGASADRMAKSATAVSMPPVPYELFVRSVHMAVALNADYVPPHDFHGSMYIRPCQFGSSCQIGLQPPDEFIFCVFVQPHIALHGHGSLRALIAEDFDRAATRGTGHVKIGGNYAPVIRWTQSAKKEENGGWDVLLHVDSKTQTRIDEFSTSAFIGTKYAEEQNEPPQIILPESAAAIQSITSDSVAWLAKSFGWNIVKQPVTIDELASLSEVMAVGTAAGLVPVSCIRHNSTNRTFEFPSAGPMYRQLKETLDNIQRGRSSDSFGWCEKLRYAEFVQ
Protein: Forked, isoform I (M9MSQ2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection, stereocilium {ECO:0000256|ARBA:ARBA00004645}.
Interaction partners:
Sequence:
MPKPAATSAAAAAAATATMKSYFSTINVKKGLLGRMTTSLTSYRRSKQKSKSNNDIHTIIATEVVTAAILSSSVHSSSTGSEIGDGGQGNTSLIEEAAAQDQSSEEQDRQHQHAKDPLAQTEMNHHPHSHHQRKSAVEVVRQQMDDDGDQDSNDDDETMPMMSGVGRKEQNNRRSVVSANTQMDNDVTPVYLAAQEGHLEVLKFLVLEAGGSLYVRARDGMAPIHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGHLSVVRWLLNHGAKLSLDKYGKSPINDAAENQQVECLNVLVQHGTSVDYNGKSSSQRHKSQQQLHQQHQQQQQQQQQQHLSSSCNSNSNSSKQTSRSNTIKSKSSSTLSSDVEPFYLHPPALAGGSGGSGMGLGMGMGMGMGMSMGLGISRKNSDALYSQQSRSSSEKLYNGSSSLGGNPGGNSSSGGGGVGGGGGSGGALLPNDGLYVNPMRNGGMYNTPSPNGSISGESFFLHDPQDIIYNRVRDLFVDSDCSSSVKQHGKSHAHQLLQSKAGNAMTIQADVHSSSSGAGSGSDESVSISSSFNSPKQQQQLRSQSFNRHGSSSNISASGNIKNNNYKAHKGKPSNQNGGGDHDYEDIYLVREESRKQHQQQQQHQLQQQQQLQHQATQQQQQQQQQQQQLQHKYNVGRSRSRDSGSHSRSASASSTRSTDIVLQYSNHHLNNKRNMNNNSNMNNSSSNIAQSSSSNNNNNSLLNRNKSHSIIGLHSSKYESSLKDNYSAKNVNLKNQLLNGGIKSDTYESVCPPEDVAERTKQTHKNSMIRNNLADASSNNNTSGSINNISNIGNMNGGNQSSRNLKRVSSAPPMQNLAVVNGPPPPPLPPPLRAPVQQQRNNLSVDQPNSMTGNNGIYKKNVFGPNQGPTNANGTGGAAPPPVPAPNPVATEAVDSDSGLEVVEEPSLRPSELVRGNHNRTMSTISANKKAKLLNAGSTNGSSIAASSDDSQSRYGGSVHAANGSAANGHFYGYSEGNKNQGSNGNGNGNGNGGGGNYHSHPNQPHYATGQPHQYTPSLYGGGSSAEDHYELTQQQQQIYGETHLPSGQRTGGPNLVNKQLVLPFVPPSFPNKSQDGVTHLIKPSEYLKSISIDKRSCPSSARSTDTEDYMQIQIAQQQSHPHQHQHHPHPHPHPHHPHQLHGMGEQPPLPPPPPPLPHGMLPPQPPMGPPMGVAGGQDATMSGKSHKPKKPHGSAPNSQDTATRKQHQPLSAISIQDLNSVQLRRTDTQKVPKPYQMPARSLSMQCLTSSTETYLKSDLIAELKISKDIPGIKKMKVEQQMASRMDSEHYMEITKQFSGNNYVDQIYLQIPERDQAGNAIPDWKRQMMAKKAAERAKKDFEERMAQEAESRRLSQIPQWKRDLLARREETENKLKAAIYTPKVEENNRVADTWRLKNRAMSIDNININLAGMEQHYQQIQFQQKQQQLQLGNKENHVDPKGADQDQEHGVGIGSGVGNANSGVIGGQELIDPSEGSQGRAEEEEDNIIPWRAQLRKTNSRLSLI
Protein: Latent-transforming growth factor beta-binding protein 2 (LTBP-2) (Q14767)
Organism: Homo sapiens (Human)
Function: May play an integral structural role in elastic-fiber architectural organization and/or assembly.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:7798248}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-2 proprotein
- Fibrillin-1
- Fibulin-5
- Growth/differentiation factor 8
- Lysyl oxidase homolog 1
- Cytochrome P450 1B1
- A disintegrin and metalloproteinase with thrombospondin motifs 10
- Latent-transforming growth factor beta-binding protein 1
- Protein Wnt-10a
Sequence:
MRPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYEPAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE
Protein: Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1) (P25409)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).
Subcellular location: Cytoplasm.
Interaction partners:
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Glutamate dehydrogenase 1, mitochondrial
- Alanine--glyoxylate aminotransferase
- N-acetylglutamate synthase, mitochondrial
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Fumarate hydratase, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Isocitrate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase cytoplasmic
Sequence:
MASRVNDQSQASRNGLKGKVLTLDTMNPCVRRVEYAVRGPIVQRALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPITFFRQVLALCVYPNLLSSPDFPEDAKRRAERILQACGGHSLGAYSISSGIQPIREDVAQYIERRDGGIPADPNNIFLSTGASDAIVTMLKLLVSGEGRARTGVLIPIPQYPLYSAALAELDAVQVDYYLDEERAWALDIAELRRALCQARDRCCPRVLCVINPGNPTGQVQTRECIEAVIRFAFKEGLFLMADEVYQDNVYAEGSQFHSFKKVLMEMGPPYSTQQELASFHSVSKGYMGECGFRGGYVEVVNMDAEVQKQMGKLMSVRLCPPVPGQALMDMVVSPPTPSEPSFKQFQAERQEVLAELAAKAKLTEQVFNEAPGIRCNPVQGAMYSFPQVQLPLKAVQRAQELGLAPDMFFCLCLLEETGICVVPGSGFGQQEGTYHFRMTILPPMEKLRLLLEKLSHFHAKFTHEYS
Protein: E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Q5U376)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAGNLKKGGGLIGMMKDAFQPHHHLHHSHHQPGAVDKKTVEKCWKFMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGDNEYFRVFMENLTKKTKQTISLFKDGKERMFEENSQPRRNLTKLSLIFSHMLAELKAIFPNGLFQGDNFRITKADAAEFWRRSFGDKTIVPWKVFRQALHEFHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQAHIDGFREGFYLFPDGRTQNPDLTGLCEPSPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESEGQGCPFCRCEIKGTEPIVVDPFDPKDPNSAASYGCRGMFGAEGAPSPSYDDDDDDRLEETPFMISKLVGSKVERPPSPMSISPQPVVPPVPPRLDLLPLRPTNPPGASSPGATSKAPSHHKDKPLPLPPALRDLPPPPPPDRPHPAGADNRLPRRPLPSTPGDPSRDKLPPAPPNRNMPDWNSRPVPKAPSQPPASGDTRGSRELSNRHSLPLQLPSTLDSRTEAPRNNGPPSLDHQLSFGSSNPASDYDSPKVKPSASANAIYSLAIRPVAAARTQTGEETNENDEESEYMTPSSRPVLPSAAGEAVPRPPPPLSLSPRSMLNELESESPQMYEAMYNIQAQALTASAPQARDSDYSELPPLTCSNGPRDPVGAYAEEEEEEENSYDYPKPHLSAALARRTLSDANSPSSSAFSRLSFDSDLGAAATVLDPSEAPERPPKPLPRRINSDRRPSPVPPGASPGPSQQISSEIEHLLSQGYSHQDIQKALMIAQNNIEMAKNVLREFVSIPSTAHILT
Protein: GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1) (Q9HCN4)
Organism: Homo sapiens (Human)
Function: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11058119, ECO:0000269|PubMed:20855544}. Nucleus {ECO:0000269|PubMed:20855544}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:20855544}.
Interaction partners:
- Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
- GPN-loop GTPase 3
- RNA polymerase II-associated protein 1
- GPN-loop GTPase 2
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB11-a
- DNA-directed RNA polymerase II subunit RPB3
- RNA polymerase II-associated protein 3
- DNA repair protein complementing XP-A cells
- DNA-directed RNA polymerase II subunit RPB7
Sequence:
MAASAAAAELQASGGPRHPVCLLVLGMAGSGKTTFVQRLTGHLHAQGTPPYVINLDPAVHEVPFPANIDIRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKAQNMSKYVLIDTPGQIEVFTWSASGTIITEALASSFPTVVIYVMDTSRSTNPVTFMSNMLYACSILYKTKLPFIVVMNKTDIIDHSFAVEWMQDFEAFQDALNQETTYVSNLTRSMSLVLDEFYSSLRVVGVSAVLGTGLDELFVQVTSAAEEYEREYRPEYERLKKSLANAESQQQREQLERLRKDMGSVALDAGTAKDSLSPVLHPSDLILTRGTLDEEDEEADSDTDDIDHRVTEESHEEPAFQNFMQESMAQYWKRNNK
Protein: ORF7a protein (ORF7a) (Accessory protein 7a) (Protein U122) (Protein X4) (P0DTC7)
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Function: Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. Acts by binding to BST2 and sequestering it to perinuclear region, thereby preventing its antiviral function at cell membrane.
Subcellular location: Host cytoplasm, host perinuclear region {ECO:0000269|PubMed:33930332}. Virion {ECO:0000250|UniProtKB:P59635}. Host endoplasmic reticulum membrane {ECO:0000269|PubMed:36574644}; Single-pass membrane protein {ECO:0000269|PubMed:36574644}. Host endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:36574644}; Single-pass type I membrane protein {ECO:0000269|PubMed:36574644}. Host Golgi apparatus membrane {ECO:0000269|PubMed:36574644}; Single-pass membrane protein {ECO:0000269|PubMed:36574644}.
Interaction partners:
Sequence:
MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE
Protein: Hemogen (Hemopoietic gene protein) (Protein RP59) (Q6AZ54)
Organism: Rattus norvegicus (Rat)
Function: Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MDVRKDQSHLTLNQTPEAHVEKSHAPDIIGSWSLRNREQLKKRKAEAQGRQTSQWQLGEQKKRKYQRTGKGNRRGRKRQGNVEQKAESWSQTENERVQEVLVPAEEETEYSGNTATQALPLRASPTKAVPTEHCSEVPQESLQCQEITIQNHSQTHQRRDKAEALSPTTCQEIGVLQYSPKMCQDMAEPEARSPKMCQETAVPQTYSPKAHEDMAEYEALSPKMCRETPVPQYHSSKIPQDMTGPEALAPDMCQETTVSQNHSSKVPQDMAGPEALSLKMCQEPTVLQEHTLKICQDVARPDVLSSKTHQEMTVPKALPCITPGDAAGPEGCSPKTLPQSDVTPMSVTPGKNTSHPDLGTAVAEGCFSEAGECIVSEDISTKTHQEAVEPKFLSHKTYKEFTVPIVSSHKTIQESPGPEEYSPGSRHEMSGPEDLSIKTCKNRDGPKHSLPEGAQEVGGAQRQDPDAQDIEDAGAFSQDLEEGNKADQDPETPAGPQGPQKICPENDVHSSALF
Protein: Myosin-3 (Myosin VIII A) (AtVIIIA) (F4I507)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables (By similarity).
Interaction partners:
- Putative B3 domain-containing protein At4g03170
- B3 domain-containing protein At1g20600
- non-specific serine/threonine protein kinase
Sequence:
MAHKVKASFQSLKTMPADYRFLGSPISDHLETNLITPPNGHLKNGVNGTASSVGGMDSVNEDSPYSVRSILNGERSSIGDGDSILPLPESNDRKWSDTNVYARKKVLQFWVQLPNGNWELGKIMSTSGEESVIVVTEGKVLKVKSETLVPANPDILDGVDDLMQLSYLNEPAVLYNLEYRYNQDMIYTKAGPVLVAVNPFKEVPLYGNRNIEAYRKRSNESPHVYAIADTAIREMIRDEVNQSIIISGESGAGKTETAKIAMQYLAALGGGSGIEYEILKTNPILEAFGNAKTLRNDNSSRFGKLIEIHFSETGKISGAQIQTFLLEKSRVVQCTEGERSYHIFYQLCAGASPTLREKLNLTSAKQYNYLKQSNCYSINGVDDAERFHAVKEALDIVHVSKEDQENVFAMLAAVLWLGNVSFTIIDNENHVEPEPDESLSTVAKLIGCNINELKLALSKRNMRVNNDTIVQKLTLSQAIDARDALAKSIYACLFDWLVEQINKSLAVGKRRTGRSISILDIYGFESFNKNSFEQFCINYANERLQQHFNRHLFKLEQEEYIQDGIDWTRVDFEDNQECLSLFEKKPLGLLSLLDEESTFPNGTDLTLANKLKQHLNDNSCFRGDRGKAFTVAHYAGEVTYETTGFLEKNRDLLHSDSIQLLSSCSCHLPQAFASSMLIYSEKPLVGPLHKAGGADSQRLSVATKFKGQLFQLMQRLGNTTPHFIRCIKPNNVQSAGLYEQGLVLQQLRCCGVLEVVRISRSGFPTRMFHHKFARRYGFLLLENIAAKDPLSVSVAILHQFNILPEMYQVGYTKLFFRTGQIGVLEDTRNRTLHGILRLQSYFRGHQARCRLKELKTGITILQSFVRGEKMRKEYTELLQRHRASAAIQSHVKRRIASQQYKATVDASAVIQSAIRGELVRRCAGDIGWLSSGGTKRNESDEVLVKASYLSDLQRRVLRTEAALREKEEENDILRQRVQQYDNRWSEYETKMKSMEEIWQKQMKSLQSSLSIAKKSLEVEDSARNSDASVNASDATDLDSGGSHYQMGHGRSRSVGVGLSVISRLAEEFGQRAQVFGDDRKFLMEVKSGQVEANLNPDRELRRLKQMFETWKKDYGGRLRETKLILSKLGSEETGGSAEKVKMNWWGRLRSTRY
Protein: Large ribosomal subunit protein eL27x (60S ribosomal protein L27-3) (P51419)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL24z
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein uL4z
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS19z
- Large ribosomal subunit protein eL22z
- Small ribosomal subunit protein eS7z
- Large ribosomal subunit protein uL24y
- Large ribosomal subunit protein eL8z
Sequence:
MVKFLKQNKAVILLQGRYAGKKAVIIKSFDDGNRDRPYGHCLVAGLKKYPSKVIRKDSAKKTAKKSRVKCFIKLVNYQHLMPTRYTLDVDLKEVATLDALQSKDKKVAALKEAKAKLEERFKTGKNRWFFTKLRF
Protein: DNA ligase 3 (K7EQB6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQSKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLH