wanglab/gogpt-training-data huggingface dataset:
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (E9PF63)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
Sequence:
MVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS
Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (A0A1D8PSH7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- GTPase
- 60S ribosomal export protein NMD3
- Probable metalloprotease ARX1
- Rei1p
- Ribosome biogenesis protein RLP24
- Eukaryotic translation initiation factor 6
- Peptidase M24 domain-containing protein
- Ribosome assembly factor mrt4
- Nucleolar GTP-binding protein 1
- 20S-pre-rRNA D-site endonuclease NOB1
Sequence:
MSVKRILGGLYLSSIDPIFKEIDLKSEYGITHILSVVPGTMKESYFSDYEWKQIEITDEETTNVIQYFPESYAFIESALFQNSNDKKHQSCVLVHCSQGVSRSATFIIAYLMQKYHLSIDQALHAVKRKCPGAEPNPGFMNQLKLYNEMGFKIDESNQKYNEILKSNSLKTDPTGRSLRDMIMEKSGSPKEVKEESLYELRCKRCRQILASSVHIENHDIPESDSRQSSFIKTAPNSRRIISVERASSVCSHYFFKEPVKWMKQELDKAEMEGKFQCPKCSSKVGGYSWRGSRCSCGKWMVPAIHLQEAKVDYIKRESTLRN
Protein: Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Tumor progression locus 2) (TPL-2) (Q63562)
Organism: Rattus norvegicus (Rat)
Function: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Nuclear factor NF-kappa-B p105 subunit
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Dual specificity mitogen-activated protein kinase kinase 1
- Dual specificity mitogen-activated protein kinase kinase 2
- NF-kappa-B essential modulator
- RAC-alpha serine/threonine-protein kinase
- Mitogen-activated protein kinase kinase kinase 14
- RAC-gamma serine/threonine-protein kinase
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- RAC-beta serine/threonine-protein kinase
Sequence:
MEYMSTGSDEKEEIDLLINHLNVSEVLDIMENLYASEEPAVYEPSLMTMCPDSNQNKEHSESLLRSGQEVPWLSSVRYGTVEDLLAFANHISNTTKHFYRCRPQESGILLNMVISPQNGRYQIDSDVLLVPWKLTYRSIGSGFVPRGAFGKVYLAQDMKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYLPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHEALNPPREDQPRCQSLDSALFDRKRLLSRKELELPENIADSSCTGSTEESEVLRRQRSLYIDLGALAGYFNIVRGPPTLEYG
Protein: LD16082p (Ral guanine nucleotide dissociation stimulator-like, isoform A) (Ral guanine nucleotide exchange factor 2) (Q9U4U5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNFTSRANCKCPHSQKHQQKPALIKSHTCAYQLQDLTGYNRALMPPLDNTDFSNAWRQVNNNTTSQSCAYHQQRQQQQQQQDAKDSKRHYHHHTCPRQRKKSMTPVEPTHLCQKHQEAKQRRSRSASAKPRRNSSYHSYDDLDVSSAVLNAERKVVASLKYLCACTGATLRNLSKKTKDLHAKNYTYTKPTWRLWGEEHEKNAIFTVYLKKVRYHRPTPTASNDSDDEISHLEWETVRVRFVKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPPPPAPRKSVVSTNTSLTNTTASSTASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQHASLMSASSSVSNLSLDSSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPSSGTPHSAPDFYIIRVTYETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLEDDPDRFTLAQVLPDKELVMPKNANVYYAVNTNYNLNFILRPRKEEGVAGS
Protein: Homeobox-DDT domain protein RLT2 (Protein RINGLET 2) (Q9FFH1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator required for the maintenance of the plant vegetative phase. In association with CHR11 or CHR17 may prevent the early activation of the vegetative-to-reproductive transition by regulating key genes that contribute to flower timing, such as FT, SEP1, SEP3, AGL8/FUL, SOC1 and FLC. Involved in the transcriptional regulation of seed-specific gene expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:22694359}.
Interaction partners:
- FHA domain-containing protein FHA2
- Homeobox-DDT domain protein RLT1
- PHD-finger and DNA binding domain-containing protein
- Protein ANTHESIS POMOTING FACTOR 1
- WD-40 repeat-containing protein MSI3
- DDT domain-containing protein DDR4
- Zinc-finger domain of monoamine-oxidase A repressor R1 protein
- PHD finger family protein
- DDT domain-containing protein PTM
- DDT domain-containing protein
Sequence:
MEGGSEKTTPEGCGGESKSKRKMKTAAQLEVLENTYSAEPYPSEAIRADLSVKLNLSDRQLQMWFCHRRLKERKSTTPSKRQRKELVTPTAMESWEPPVNAGDLVAGNELDSRRAARGSGGSGVTVVRRFNEPSSAEVRAIGYVEAQLGERLRDNGPVLGMEFDPLPPGAFGMPIEMPSHRKATRQAFETNIYVRSDVKPIKDHVRPIREYQFIPELPSSRTDHSERVSPSHHFGVPLDGSVMRVSAVSAGHRDDYKISPQIPNLNLATHQGKPGHVYSPNLVEYDSPYQKSYMDTAAQVHDDPFVKSEREVGNEDEDDDALQLERHRKNEEARIAREVEAHEKRIRRELEKQDMLRRKREEQIRKEMERQDRERRKEEERLLREKQREEERYLKEQMRELQRREKFLKKETIRAEKMRQKEEMRKEKEVARLKAANERAIARKIAKESMELIEDERLELMEVAALTKGLPSMLALDFETLQNLDEYRDKQAIFPPTSVKLKKPFAVKPWNGSDENVANLLMVWRFLITFADVLGLWPFTLDEFAQAFHDYDPRLMGEIHIVLLKTIIKDIEGVVRTLSTGVGANQNVAANPGGGHPHVVEGAYAWGFDIRSWRKNLNVFTWPEILRQLALSAGLGPQLKKMNIRTVSVHDDNEANNSENVIFNLRKGVAAENAFAKMQERGLSNPRRSRHRLTPGTVKFAAFHVLSLEGEKGLNILEVAEKIQKSGLRDLTTSRTPEASVAAALSRDTKLFERVAPSTYCVRASYRKDAGDAETIFAEARERIRAFKSGITDVEDVDDAERDEDSESDVGEDPEVDVNLKKEDPNPLKVENLIGVEPLLENGKLDTVPMKTELGLPLTPSLPEEMKDEKRDDTLADQSLEDAVANGEDSACFDESKLGEQWVQGLVEGDYSNLSSEERLNALVALIGIATEGNTIRIALEERLEVASALKKQMWGEVQLDKRWKEESLIRANYLSYPTAKPGLNIATPASGNQESSSADVTPISSQDPVSLPQIDVNNVIAGPSLQLQENVPGVENLQYQQQQGYTADRERLRAQLKAYVGYKAEELYVYRSLPLGQDRRRNRYWRFSASASRNDPGCGRIFVELQDGRWRLIDSEEAFDYLVKSLDVRGVRESHLHFMLLKIEASFKEALRRNVAANPGVCSISSSLDSDTAEISTTFKIELGDSNAVERCSVLQRFHSFEKWMWDNMLHPSALSAFKYGAKQSSPLFRICRICAELHFVGDICCPSCGQMHAGPDVGELCFAEQVAQLGDNLRRGDTGFILRSSILSPLRIRLLKVQLALVEASLPPEGLEAFWTENLRKSWGMKLLSSSSHEDLYQVLTTLEAALKRDFLSSNFETTSELLGLQEGALASDLTCGVNVLPWIPKTAGGVALRLFDFDSSIVYTPDQNNDPLKDKESEDFVGLETNILRNLHEKDVMETPVQVAAYKQEENWTDPGLGGVSSSGRGGRPPRGRGRPRARGNGKKPAVSVKPPRGAANSNGETMLRPRAQPRGGRKNGRRSGTKGRKRPTQGTLGICNEVGGGRRVKEVAVTAKTSLPDNDDDWIETPELQDDDGEASSSGRSFQYEDYDDDDVMAPIDDFDGGGESSKLVGRGEFSLHSDDEYEEEEEEEEDMNMKMDVNVVDDEDEDYINEDSYGRKQHGISISNDAATRKRFNKFEDPDLTSSSSSDFQ
Protein: Olfactory receptor (Q9Z1U5)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
ANLSFVDVCFTTNLIPRLLAGHVAGTRTISYVHCLTQTYFLISFANVDTFLLAAMALDRFVAICYPLQYHTIITPQLCVGLAAVVWMCSALISLMHTLLMSRLSFCSSIPEISHFYCDAYLLMKLACSDTRVNQLVFLGAVVLFVAPCILIVVSYVRITMVVLQIPSAKGRHKTFSTCSSHLSVVTLFYGTVLGIYIRPPDSFSTQDTVATIMYTVVTPMLN
Protein: Dihydropyrimidinase-related protein 5 (DRP-5) (Collapsin response mediator protein 5) (CRMP-5) (Q9EQF6)
Organism: Mus musculus (Mouse)
Function: Involved in the negative regulation of dendrite outgrowth.
Subcellular location: Cytoplasm {ECO:0000250}. Note=Translocates into the mitochondria upon interaction with SEPTIN4 isoform 4. {ECO:0000269|PubMed:12581152}.
Interaction partners:
- Dihydropyrimidinase-related protein 2
- Tyrosine-protein kinase Fes/Fps
- Dihydropyrimidinase-related protein 3
- Dihydropyrimidinase-related protein 4
- Amphiphysin
- Myc box-dependent-interacting protein 1
- Uridine 5'-monophosphate synthase
- Dihydroorotate dehydrogenase
- Leucine-rich glioma-inactivated protein 1
Sequence:
MLANSASVRILIKGGKVVNDDCTHEADVYIESGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVEAYEKCRALADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVFHACRDIGAIPRVHAENGELVAEGAKEALDLGITGPEGIEISHPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTNAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVVWERGVVGGKMDENRFVAVTSSNAAKILNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDIVYKKLVQREKTLKVRGVDRTPYLGDVAIVVHPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW
Protein: Peroxiredoxin-2C (EC 1.11.1.25) (Glutaredoxin-dependent peroxiredoxin) (Peroxiredoxin IIC) (Peroxiredoxin TPx2) (Thioredoxin peroxidase 2C) (Thioredoxin-dependent peroxidase 2) (Q9SRZ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- 2-Cys peroxiredoxin BAS1, chloroplastic
- 2-Cys peroxiredoxin BAS1-like, chloroplastic
- Peroxiredoxin Q, chloroplastic
- NADPH-dependent thioredoxin reductase 3
- Peroxidase 38
Sequence:
MAPITVGDVVPDGTISFFDENDQLQTVSVHSIAAGKKVILFGVPGAFTPTCSMSHVPGFIGKAEELKSKGIDEIICFSVNDPFVMKAWGKTYPENKHVKFVADGSGEYTHLLGLELDLKDKGLGIRSRRFALLLDNLKVTVANVESGGEFTVSSAEDILKAL
Protein: Alpha-2-HS-glycoprotein (Alpha-2-Z-globulin) (Ba-alpha-2-glycoprotein) (Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B] (P02765)
Organism: Homo sapiens (Human)
Function: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Subcellular location: Secreted.
Interaction partners:
- Albumin
- Toll-like receptor 4
- Fibrinogen alpha chain
- Prothrombin
- Matrix Gla protein
- Alpha-1-antitrypsin
- Fibrinogen gamma chain
- Vitamin D-binding protein
- Beta-2-glycoprotein 1
- Apolipoprotein A-I
Sequence:
MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLKLDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGGAEVAVTCMVFQTQPVSSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVLLAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPGRIRHFKV
Protein: V-type proton ATPase subunit a (Q6NY92)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGELFRSEEMTLAQLFLQSESAYCCVSELGEIGMVQFRDLNPDVNAFQRKFVNEVRRCEEMDRKLRFVEKEIKKANIPIVDTGENPEVPFPRDMIDLEATFEKLENELKEINTNQEALKKNFLELTELKHILRRTQQFFDEMEDPSLLEESSTLLDPNEVGRAAPLRLGFVAGVIGRERIPTFERMLWRVCRGNVFLRQADIEDPLEDPATGDNVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMAAGVNTRIDDLQMVLNQTEDHRQRVLQAAAKTVRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEIWCPVSDLDSIQFALRRGTERSGSTVPSILNRMQTKQTPPTYNKTNKFTSGFQSIVDAYGIGNYREMNPAPYTIITFPFLFAVMFGDLGHGVLMTCAALYLVLRESRLIAQKNDSEMFSMVFAGRYIILLMGLFSMYTGIIYNDCFSKSLNIFGSGWSVRPMFGEKGDNWTFAVLEKSNVLQLNPAVPNVFTGPYPVGIDPIWNIATNKLTFLNSFKMKMSIILGVIHMIFGVSLSLFNHLYFRKPLNIYLGFIPEIIFMVSLFGYLVLLIFYKWIAYDAKSSRVAPSLLITFINMCLFSYNDPTNKPFYTGQVVIQCLLVIIALSCVPCMLIVKTLVMRRQHLWRRHLGTQNFGGIHVGNGPTEDEAEIIQHDQLSQNTEEEPEFNFADEAVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWSMVMHMGLSSRSFGGFIFLSIIFCFFAVLTVFILLVMEGLSAFLHALRLHWVEFQNKFYTGQGFKFMPFTFDSILDGKSEE
Protein: Protein E6 (Q9WNN0)
Organism: human papillomavirus 83
Subcellular location: Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123}. Host nucleus {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123}.
Interaction partners:
Sequence:
MSGVRYPTNIFLLCKDCEVDLEDLRLICIYCTNELTTAEVLSFAWKELCIKWDHELPYGACAQCLRKAAKVRELRHWSHSSYGATVEEETKTPLAQLYIRCHMCLKPLSSQEKEYLVQTGDRLHNIAGQWTGRCCHCRAPCTAIQQQ
Protein: Pex17p (Q9UV55)
Organism: Komagataella pastoris (Yeast) (Pichia pastoris)
Interaction partners:
Sequence:
MSSRRNVQAIAFPENLPPSRLVTPKPAALLYLTRLLYGSGSFLVVVYALALFLIRPMLKLQYERRGSYLNHCLDKLNAMYGLVAKRLRFVPEVRVKYGNTVYSDAGMQTDPKKEEVDNTFNPFLYQHKYQNNGFGRQTIKFEDEEEKRDRSESDRLGGSIQDLKNTLEKLEVSSYKQAGASLSLRGDTSRMSEMQPLMFQVKQLENYMEGLSSEHPKDSMFKRALGYGSYGKPQAKLTNRTAHIVSDIKGDISFLKAEIEKRNRSST
Protein: polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase 1) (Q562B9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
QLEIIESFNVVAKEVFRSIILNEYKRCDGRDLTSLRNISCEVDMFKTLHGSALFQRGQTQVLCTVTFDSLESSIKSDQIITAINGVKDKNFMLHYEFPPYATNETGKVTGVNRRELGHGALAEKALCPVIPKDFPFTIRVTSEVLESNGSSSMASACGGSLALMDAGVPISSAVAGVAVGLVTKSNPEKGEIEDYRLLTDILGIEDYNGDMDFKIAGTNKGITALQADIKLPGVPVKIIMEAIQQATVAKREILQTMSKTISKPRASRKENGPVVETVKVPLSKRAKFIGPGGYHLKKLQAETGVTISQVDEETFSIFAPTPTAMHEARDFITEICRDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNSQLDQRKIKHPTALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVLKTLNDRSSIVMGEPISQSSSNSSP
Protein: Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1 (EC 2.7.11.1) (Protein BARELY ANY MERISTEM 1) (O49545)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Necessary for male gametophyte development, as well as ovule specification and function. Involved in cell-cell communication process required during early anther development, and regulating cell division and differentiation to organize cell layers. Required for the development of high-ordered vascular strands within the leaf and a correlated control of leaf shape, size and symmetry. May regulate the CLV1-dependent CLV3-mediated signaling in meristems maintenance.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14506206, ECO:0000269|PubMed:20626648}; Single-pass type I membrane protein {ECO:0000269|PubMed:14506206, ECO:0000269|PubMed:20626648}.
Interaction partners:
- Putative pentatricopeptide repeat-containing protein At5g43820
- At1g62305
- Protein IDA-LIKE 4
- Protein IDA
- Electron transporter
- Probable LRR receptor-like serine/threonine-protein kinase PAM74
- Probable sphingolipid transporter spinster homolog 1
Sequence:
MKLFLLLLFLLHISHTFTASRPISEFRALLSLKTSLTGAGDDKNSPLSSWKVSTSFCTWIGVTCDVSRRHVTSLDLSGLNLSGTLSPDVSHLRLLQNLSLAENLISGPIPPEISSLSGLRHLNLSNNVFNGSFPDEISSGLVNLRVLDVYNNNLTGDLPVSVTNLTQLRHLHLGGNYFAGKIPPSYGSWPVIEYLAVSGNELVGKIPPEIGNLTTLRELYIGYYNAFEDGLPPEIGNLSELVRFDGANCGLTGEIPPEIGKLQKLDTLFLQVNVFSGPLTWELGTLSSLKSMDLSNNMFTGEIPASFAELKNLTLLNLFRNKLHGEIPEFIGDLPELEVLQLWENNFTGSIPQKLGENGKLNLVDLSSNKLTGTLPPNMCSGNKLETLITLGNFLFGSIPDSLGKCESLTRIRMGENFLNGSIPKGLFGLPKLTQVELQDNYLSGELPVAGGVSVNLGQISLSNNQLSGPLPPAIGNFTGVQKLLLDGNKFQGPIPSEVGKLQQLSKIDFSHNLFSGRIAPEISRCKLLTFVDLSRNELSGEIPNEITAMKILNYLNLSRNHLVGSIPGSISSMQSLTSLDFSYNNLSGLVPGTGQFSYFNYTSFLGNPDLCGPYLGPCKDGVAKGGHQSHSKGPLSASMKLLLVLGLLVCSIAFAVVAIIKARSLKKASESRAWRLTAFQRLDFTCDDVLDSLKEDNIIGKGGAGIVYKGVMPNGDLVAVKRLAAMSRGSSHDHGFNAEIQTLGRIRHRHIVRLLGFCSNHETNLLVYEYMPNGSLGEVLHGKKGGHLHWDTRYKIALEAAKGLCYLHHDCSPLIVHRDVKSNNILLDSNFEAHVADFGLAKFLQDSGTSECMSAIAGSYGYIAPEYAYTLKVDEKSDVYSFGVVLLELVTGRKPVGEFGDGVDIVQWVRKMTDSNKDSVLKVLDPRLSSIPIHEVTHVFYVAMLCVEEQAVERPTMREVVQILTEIPKLPPSKDQPMTESAPESELSPKSGVQSPPDLLNL
Protein: Hydrolase, alpha/beta hydrolase fold family (O69638)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MAAPDPSMTRIAGPWRHLDVHANGIRFHVVEAVPSGQPEGPDAATPPMQPALARPLVILLHGFGSFWWSWRHQLCGLTGARVVAVDLRGYGGSDKPPRGYDGWTLAGDTAGLIRALGHPSATLVGHADGGLACWTTALLHSRLVRAIALISSPHPAALRRSTLTRRDQRHALLPTLLRYQLPIWPERLLTRNNAAEIERLVRARGCAKWLASEDFSQAIDHLRQAIQIPAAAHCALEYQRWAVRSQLRSEGRRFIRAMTQQLGMPLLHLRGDADPYVLADPVERTQRYAPHGRYISIAGAGHFSHEEAPEEVNRHLMRFLEQVHQLS
Protein: CRISPR-associated endonuclease Cas6/Csy4 (EC 3.1.-.-) (Q02MM2)
Organism: Pseudomonas aeruginosa (strain UCBPP-PA14)
Function: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units. Absolutely required for crRNA production or stability. Upon expression in E.coli endonucleolytically processes pre-crRNA, although disruption and reconstitution experiments indicate that in situ other genes are also required for processing. Yields 5'-hydroxy and 3'-phosphate groups. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.
Interaction partners:
Sequence:
MDHYLDIRLRPDPEFPPAQLMSVLFGKLHQALVAQGGDRIGVSFPDLDESRSRLGERLRIHASADDLRALLARPWLEGLRDHLQFGEPAVVPHPTPYRQVSRVQAKSNPERLRRRLMRRHDLSEEEARKRIPDTVARALDLPFVTLRSQSTGQHFRLFIRHGPLQVTAEEGGFTCYGLSKGGFVPWF
Protein: WD repeat domain 11 (S4R3Z0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLLLYPREILILDLEVNQTVGVIAIERTGVPFLQVIPCFQRDGLFCLHENGCITLRVRRSYNNIFTTSNEEPDPDPVQELTYDLRSQCDAIRVTKTVRPFSMVCCPVNENAAALVVSDGRVMIWELKSAVCNRNSRNSSSGVSPLYSPVSFCGIPVGVLQNKLPDLSLDNMIGQSAIAGEEHPRGSILREVHLKFLLTGLLSGLPAPQFAIRMCPPLTTKNIKMYQPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSFATSTPNNMGLVRNELQLVDLPTGRSIAFRGERGNDESAI
Protein: Transmembrane protein, putative (DUF2358) (Q8L604)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Photosystem II D2 protein
Sequence:
MTTSSFLLPASPPSAAFLRRRFFRHSWLSSKIHHRLPQVMNDSTRTEVSIDKSEVDKLVDKIDFGELCNDFECTSSPQVESTARQLVRDILEIREGNRAFACYAVSVKYKDPVRSFTGREKYKRPMWITSGLENPTVTVQEMVMLSTSVLRIKWTVKGKPKSILAAVSGDLIVKVKSEFTLNQISGQVFEHEESWDLSSSSPIAQAYFWTSRRLFAASESAKDVADVTKDLTANLTTRKEDTDIYRDPTDPNKFFQRDNSFERDVYQIALFLAIVYFVVQFLKNTI
Protein: 2-oxoglutarate dehydrogenase complex component E1 (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) (E9PDF2)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQVRGHHIAKLDPLGISCVNFDDAPVTVSSNVDLAVFKERLRMLTVGGFYGLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPRSMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEHKNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDVFKNFS
Protein: Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) (P38646)
Organism: Homo sapiens (Human)
Function: Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:26702583}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:24625977}. Cytoplasm {ECO:0000269|PubMed:24625977}. Mitochondrion matrix {ECO:0000250|UniProtKB:P48721}. Note=Found in a complex with HSPA9 and VDAC1 at the endoplasmic reticulum-mitochondria contact sites. {ECO:0000250|UniProtKB:P48721}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit TIM44
- GrpE protein homolog 1, mitochondrial
- 60 kDa heat shock protein, mitochondrial
- Non-selective voltage-gated ion channel VDAC1
- Cellular tumor antigen p53
- Mitochondrial import inner membrane translocase subunit TIM14
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- DnaJ homolog subfamily A member 3, mitochondrial
- Parkinson disease protein 7
Sequence:
MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ
Protein: Putative diacyglycerol O-acyltransferase Rv0895 (EC 2.3.1.20) (Putative triacylglycerol synthase Rv0895) (P9WKA3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Upon expression in E.coli functions very weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity.
Interaction partners:
- Triacylglycerol lipase
- Uncharacterized protein Rv0894
- Diacylglycerol kinase
- Uncharacterized protein Rv1359
- HTH-type transcriptional regulator VirS
- Uncharacterized oxidoreductase Rv1543
- Uncharacterized protein Rv1355c
- Uncharacterized protein Rv1354c
- Probable transcriptional regulatory protein
- HTH-type transcriptional regulator Cmr
Sequence:
MRQQQEADVVALGRKPGLLCVPERFRAMDLPMAAADALFLWAETPTRPLHVGALAVLSQPDNGTGRYLRKVFSAAVARQQVAPWWRRRPHRSLTSLGQWSWRTETEVDLDYHVRLSALPPRAGTAELWALVSELHAGMLDRSRPLWQVDLIEGLPGGRCAVYVKVHHALADGVSVMRLLQRIVTADPHQRQMPTLWEVPAQASVAKHTAPRGSSRPLTLAKGVLGQARGVPGMVRVVADTTWRAAQCRSGPLTLAAPHTPLNEPIAGARSVAGCSFPIERLRQVAEHADATINDVVLAMCGGALRAYLISRGALPGAPLIAMVPVSLRDTAVIDVFGQGPGNKIGTLMCSLATHLASPVERLSAIRASMRDGKAAIAGRSRNQALAMSALGAAPLALAMALGRVPAPLRPPNVTISNVPGPQGALYWNGARLDALYLLSAPVDGAALNITCSGTNEQITFGLTGCRRAVPALSILTDQLAHELELLVGVSEAGPGTRLRRIAGRR