wanglab/gogpt-training-data huggingface dataset:
Protein: Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase) (P21900)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03125}.
Interaction partners:
- Adenylosuccinate lyase
- Bifunctional purine biosynthesis protein purH
- Inosine-5'-monophosphate dehydrogenase
- Bifunctional purine biosynthetic protein purD
- Multifunctional protein pyr1-3
- Hypoxanthine-guanine phosphoribosyltransferase
- Inosine triphosphate pyrophosphatase
- AMP deaminase
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
Sequence:
MASIIIGSQWGDEGKGKLVDILSQQFDVVARCQGGANAGHTIVVDGKKIALHLIPSGILNEKASCILGNGMVIHLPTFFKEVQGLQDKGINYKGRLFVSDRAHLVFDLHQMIDAMKEAELSNGTSNDSIGTTKRGIGPCYSSKASRGGLRVCDLYSPEHFRKTFTRLVENKHKRFGSFEYDVEAELKRYQEFAEMLKPFVIDSVYYLNQAFKDGKKVLIEGAQSTMLDLDFGCYPYVTSSASSVGGACTGLGISPNKVVTQIGVVKAYTTKVGSGPFPTEQNDHVGDSLRKAGSEFGTTTGRPRRIGWLDAVVLRYTSMINDFTRLNLTKLDVLSDFEEIKIGVDYKYKGETIKSFPASLETLAQCEVVYESFPGWKCDLSHVTEYDQLPIQAKNYIKRIEELVGVPIVYIGVGVERKNLIERKELI
Protein: BCL2 associated transcription factor 1 (E9PK09)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQKATEEHSTRQKSPEIHRIDISPSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKT
Protein: Lipoprotein NlpE (Copper homeostasis protein CutF) (P40710)
Organism: Escherichia coli (strain K12)
Function: Involved in copper homeostasis, could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes. Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation. Functions during envelope stress responses; when overproduced induces degP through the activation of the two-component envelope stress response system CpxA/CpxR. DegP induction seems to require membrane anchoring of this protein. Structural changes and/or interaction of the CXXC motif with its environment may lead to activation of the Cpx stress response.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:15252048, ECO:0000305|PubMed:7635808}; Lipid-anchor {ECO:0000305|PubMed:15252048, ECO:0000305|PubMed:7635808}.
Interaction partners:
- Sensor histidine kinase CpxA
- Transcriptional regulatory protein CpxR
- Periplasmic protein CpxP
- Peptidyl-tRNA hydrolase ArfB
- Uncharacterized protein YaeQ
- Outer membrane lipoprotein RcsF
- PF03932 family protein CutC
Sequence:
MVKKAIVTAMAVISLFTLMGCNNRAEVDTLSPAQAAELKPMPQSWRGVLPCADCEGIETSLFLEKDGTWVMNERYLGAREEPSSFASYGTWARTADKLVLTDSKGEKSYYRAKGDALEMLDREGNPIESQFNYTLEAAQSSLPMTPMTLRGMYFYMADAATFTDCATGKRFMVANNAELERSYLAARGHSEKPVLLSVEGHFTLEGNPDTGAPTKVLAPDTAGKFYPNQDCSSLGQ
Protein: AT01906p (Q8MSP9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MFNSQLRKQSVQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLLSAFHPKTP
Protein: Zbtb16 protein (A3KMN0)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
KANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKILETIQASDDNDTEATMADGGGEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMSIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAEVKMEMMQVDEAPGQDSPGAAESSISGGMGDKLEERSKEGPGTPTRGSVITSARELHYGREESGEQLSPPVEAGQGPPGRQEPLAPPVEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKAESRPLGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV
Protein: Uncharacterized protein (Q57YF4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNEGKGTSHATSEMTKDTGGESVVELARGNSRRKLSPRPRQEVADALREGVGGTVETPDEEEEVFLFDKMVRQTMKPTLTPLFAVSWCWPKVSEESVPQRDAETDHCQWDIGPTTITELRGDPRLRRGNRLIALIITEGRRFLLPLIPERREDDDSPESGVYWQVPTRPYEVQLSQSPRAQLVIGTLQHVEEVNDMVRRFAESGSQHDDNVSLTTGEPIAESEGTLHSPLGTFSFSSIPCRCLWLYRIPNCVVVSLPCEERLVFINTGPGVECKSIAPRVLANVLSCVSSFSFPRHVVPLDVNEIFDRPFVVVGTLLHGVLVVHVEDCGICTGIVHHIPLTGLVSSIFPVTRLASVFPARRNRGEEISETSGAYWLKSGLFSQCLDGVIICSSPYEDRAVVVKCASATNGGCGYELAPPKRFFCGISSATYTYSSVGTVVGTLDGKVMSVLASTELTEDGSGSKSYKEFRRCRHSAAYDATCPAFVCTVLARNMTSGALTFICEGGPVLQKTSHTKYQRSFVRHWLCHSTTLNEVVLLDRNLQSYAVHSTVPLGPPESDHFDEEAPDDLRRETDQNTDNNREREEGSDTANVHLENGNRPHQPLENIISGLSWLLVEDGFLQVIVAHHKNWLSTITWKT
Protein: Capsid protein (Q1JTL4)
Organism: Penicillium stoloniferum virus S
Interaction partners:
Sequence:
MSSIAPTDSVSSSGKRSKPGKRERQQARSAVGSAGGKPASASKAAAFAQGGSSDPVPMPGKYPVVFSTGAGEPTRDQEFALPVHKAFPLFGSVSDKYRRNPRYAEFRAHSEFTDGVFGTHLAVSSLLRLAQQLVHAHVNMGLPLGDFAPLASSDVRIPSALASXXXQFGEFSSPSIGTRFLLRDYEHAVSRVVFLADQLWTNGNSHHIFARSWLPMSNNDGNFKTIVASRLLEFISAGDLSILPTVLEDAVLSGEVPEAWEQVKDLLGDAPGVGQVDRRDRFDFLFKSYADVGQFTTAFTTQAASDVLTELGLPWNSPSAGHLNWQYSTKQRFTFLADTWAKLSAAYSQFFELSSGLATRQSATGSHAQMVDLTSVEGVTVLKAALALSAPEFSLAACFPPSCIFVGGITRRVVVTTSLSVSQRATEFCQMDWR
Protein: Cyclin D1 (G1/S-specific cyclin-D1) (Q6GLD3)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Interaction partners:
Sequence:
MELLCCEVDTIRRAHLDRNLITDRVLQTMLKAEETCCPNVSYFKCVQKEILPHMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVKTLRKSQLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLLMELLILNKLKWDLASVTPHDFIEHFLNKMPLTEDTKQIIRKHAQTFVALCATDIKFISNPPSMIAAGSVAAAVQGLNLGNADSVFSTQRLTLFLSQVIKCDPDCLRACQEQIESLLESSLRQAQQQHNTSSDTKNMVEEADISCTPTDVRDVNI
Protein: Niemann-Pick C1-like 1 protein (A0MJA4)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MADTGLRGWLLWALLLHVAQSELYTPIHQPGYCAFYDECGKNPELSGGLAPLSNVSCLSNTPALRVTGEHLTLLQRICPRLYTGTTTYACCSPKQLLSLETSLAVTKALLTRCPTCSDNFVNLHCQNTCSPNQSLFINVTRVAGGGGGRPQAVVAYEAFYQDTFAQQTYDSCSRVRIPAAATLAVGTMCGVYGSTLCNAQRWLNFQGDTSNGLAPLDITFHLMEPGQALGSGMQALTGEIRPCNESQGNGTVACSCQDCAASCPTIPQPQALDSTFYLGGLEGGLALVIILCSAFALLTTFLVGTRLASSCGKDKTPDPKAGMSLSDKLSLSTNVILSQCFQNWGTWVASWPLTILLVSIAVVLALSGGLAFVELTTDPVELWSAPSSQARSEKAFHDQHFGPFLRTNQVILTAPNRPSYHYDSLLLGPKNFSGVLASDLLLELLELQETLRHLQVWSPEEQRHISLQDICFAPLNPHNASLSDCCINSLLQYFQSNRTHLLLTANQTLTGQTSQVDWRDHFLYCANAPLTFKDGTALALSCMADYGGPVFPFLAVGGYKGKDYSEAEALIMTFSLNNYAPGDPRLAQAKLWEAAFLEEMKAFQRRTAGTFQVTFMAERSLEDEINRTTAEDLPIFGVSYIIIFLYISLALGSYSSWRRVPVDSKVTLGLGGVAVVLGAVTAAMGFFSYLGVPSSLVILQVVPFLVLAVGADNIFIFVLEYQRLPRRPGEPREAHIGRALGSVAPSMLLCSLSEAICFFLGALTPMPAVKTFALISGFAIVLDFLLQVSAFVALLSLDSRRQEASRLDVCCCVSAPKLPAPGQSEGLLLRVFRKFYVPVLLHRVTRAVVLLLFTGLFGVGLYFMCHIRVGLDQELALPKDSYLLDYFFFLNRYFEVGAPVYFVTTGGYNFSSEAGMNAVCSSAGCDSYSLTQKIQYATEFPEESYLAIPASSWVDDFIDWLTPSSCCRLYAFGANKDKFCPSTVNSLACLKNCVNFTLGPVRPSVDQFHKYLPWFLSDPPNIKCPKGGLAAYNTSVHLGSDGQVLASRFMAYHKPLRNSEDYTEALRVSRALAANITAQLRQVPGTDPAFEVFPYTITNVFYEQYLSVVPEGLFMLAICLLPTFVVCCLLLGMDLRSGLLNLFSIVMILVDTVGFMALWGISYNAVSLINLVTAVGISVEFVSHITRSFAVSTRPTRLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITVLGLLHGLVFLPVVLSYLGPDINAALVLDQKKTEEAIGAPAHLVPTSTASSTYVNYGFQHPANGVVGDSSLPRSGPDL
Protein: Galactan 5-O-arabinofuranosyltransferase (EC 2.4.2.46) (Arabinofuranosyltransferase AftA) (A0R611)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P9WN03}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P9WN03}.
Interaction partners:
- Probable arabinosyltransferase A
- Probable arabinosyltransferase B
- Alpha-
- Probable arabinosyltransferase A
- Decaprenylphosphoryl-2-keto-beta-D-erythro-pentose reductase
- Probable conserved transmembrane protein
- Alpha-
- Decaprenylphosphoryl-beta-D-ribose oxidase
- Galactofuranosyltransferase GlfT2
- Galactofuranosyltransferase GlfT1
Sequence:
MAARVLGQMVLAVLMASAVAGVAIAAIARVEWPAYNTSNQLHALTTVGQFGCLAGLFAAGLLWRRGRRTLARLGALAFISAFSVVTLAMPLGATKLYLFGVSVDQQFRTEYLTRLTDTAGLHDMTYIGLPPFYPAGWFWLGGRIAAATGTPAWEMFKPWSIVSITIAVALALVLWAAMIRFEYALVATAASTAAMLAYASTEPYAAIITVLMPPVFVLAWAGLRARTRGGGWAAIVGVGIFLGVAALFYTLLLVYAAFTLTIMALCVAVARRHIDPLLRLAVIAVISGAIALLTWAPYLLAAMRGEPADSGTAQHYLPDAGAELHFPMFSLTLHGALCMLGTVWLVVRARTSTRAGALAVAVVAVYAWSLLSMLTTLAGTTLLSFRLQPTLTVLLTTAGAFGFIEATLAIAHRYRPETSRRVVAAATAVGAIGAVTFSQDIPDVLRPDINVAYTDTDGTGQRADRRPPGAERYYREIDAKILEVTGVPRNQTVVLTADYSFLSFYPYYGFQGLTSHYANPLAQFDKRAAAIEGWATLGSADDFVAALDELPWEPPTVFLMRHGANDTYTLRLASDVYPNQPNVRRYHVELDSAVFDDPRFEVSDHGPFVLAIRKPGGKPETDGH
Protein: Glutamate decarboxylase beta (GAD-beta) (EC 4.1.1.15) (P69910)
Organism: Escherichia coli (strain K12)
Function: Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12912902}. Membrane {ECO:0000269|PubMed:12912902}. Note=Localized exclusively in the cytoplasm at neutral pH, but is recruited to the membrane when the pH falls.
Interaction partners:
- Glutamate decarboxylase alpha
- Acid stress chaperone HdeA
- Glutamate/gamma-aminobutyrate antiporter
- Glutaminase 1
- Transcriptional regulator GadE
- Protein HdeD
- 4-aminobutyrate aminotransferase GabT
- Acid stress chaperone HdeB
- 4-aminobutyrate aminotransferase PuuE
- Glutamate synthase large chain
Sequence:
MDKKQVTDLRSELLDSRFGAKSISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT
Protein: Mitochondrial phosphate transporter (O80413)
Organism: Zea mays (Maize)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
Sequence:
MALSDRSRESLLPSFLYASSARSFAATGAAARLPVSSPAPATAGAGGGVPFSIQAPKEKIEMYSPAFYAACTAGGIASCGLTHMAVTPLDLVKCNMQIDPAKYKSISSGFGILLKEQGARGFFRGWVPTLLGYSAQGACKFGFYEFFKKYYSDIAGPEYAQKYKTLIYLAGSASAEVIADVALCPFEAVKVRVQTQPGFARGLSDGLPKFVRSEGVLGLYKGIVPLWGRQIPYTMMKFASFETIVELIYKHAVPVPKSECSKTTQLGISFAGGYIAGVFCAIVSHPADNLVSFLNNAKGATVGDAVKKLGLWGLFTRGLPLRIVMIGTLTGAQWGIYDAFKVMVGLPTTGGVTPAPAAEAELKASA
Protein: MGC154553 protein (Nucleoporin 43kDa S homeolog) (Q05AW3)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MADKFAAKFVSHKISRTRWRPVSASSLQQPDVFATGSWDNEENKVCVWATSDFGATSLDEEYQGDPKQLCDIKHPGDVMDMQFLDKERIVTGSSTGTVTIFRHHENNQTLSVNQRWEQAHYHVGSNMRAPCTAIVCSSPEIVSVGEDGRINCFRAESRDVLRTIDDADSSTMHGVTFLRTTEILTVNSVGQLKLWDLRKQGNDPTQIFSVTGERVPLHCVDRHPNQQHVVATGGQDGMLCIWDVRHGKMPMSLLNAHEAEMWEVHFHPSNPDHLFTCSEDGSLWHWDASADSEKPTFLLGGRSTFNISRSSIAPPNANQSLACAWLSTDPTKGQLEITNLLPSSTLSVNSLDVLGQNLVCGTDAEAIYVTRRLFS
Protein: Cytochrome c-type biogenesis protein CcmF (Q9I3N2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity).
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Thiol:disulfide interchange protein DsbE
- Cytochrome c-type biogenesis protein CcmE
- Cytochrome c-type biogenesis protein CcmH
- Heme exporter protein C
- Cytochrome c-type biogenesis protein CycH
- Heme exporter protein D
- Heme exporter protein B
- Cytochrome c biogenesis ATP-binding export protein CcmA
- Cytochrome c
- Probable FAD-dependent monooxygenase
Sequence:
MIPELGHLALILALCLALVQSSLPLVGAWRGDRQWMSLARPAAWGQFAFLAFAFGCLTWAFLRDDFSVAYVAGNSNSALPWYYKFSAVWGAHEGSLLLWALILGGWTFAVSIFSRQLPEVMLARVLAVMGMISTGFLLFLIITSNPFSRLLPQTPMDGNDLNPLLQDVGLIVHPPMLYMGYVGFSVAFAFAIAALLGGRLDAAWARWSRPWTLVAWAFLGIGIVLGSWWAYYELGWGGWWFWDPVENASFMPWLVGTALIHSLAVTEKRGVFKSWTVLLAIAAFSLSLLGTFLVRSGVLTSVHAFASDPERGVFILAFLLLVVGGSLTLFALRAPVVKSQVGFALWSRETLLLLNNLVLVVAASMILLGTLYPLLLDALSGAKLSVGPPYFNAMFLPLMAALMAALAVGVLVRWKDTPSRWLLGMLTPVLAASAVLAAAGSMYFGDFNWAVLAVFLLSAWVVLAGFRDFLDKTRHKGVLAGARSLTRSYWGMQLAHLGIAVCAIGIVLSSQYSAQRDLRMSPGDTVELGGYHFLFDGAKHHEGPNYTSDKGSIHVSRDGKEIATLHPEKRLYTVQSSMMTEAGIDAGFTRDLYVALGEPLENGAWAVRVHVKPFVRWIWFGGLLMGLGGALAALDRRYRVKVKTRVREALGLAGQGA
Protein: Uncharacterized protein (Q9N938)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFQLVSVAEVNKAYVSYPGGVSMCLRFPFCHCVWAHAMTLIEISGHYHRWVARGESEDWDYSNSFVVVCAVLLENIAANEREGKCHLTFHAATSMHHDYMLVALRGKAVKAKVSFRFKEV
Protein: Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339) (Q9BRP0)
Organism: Homo sapiens (Human)
Function: Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos (By similarity). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8CIV7}.
Interaction partners:
- Grainyhead-like protein 2 homolog
Sequence:
MPKVFLVKRRSLGVSVRSWDELPDEKRADTYIPVGLGRLLHDPPEDCRSDGGSSSGSGSSSAGEPGGAESSSSPHAPESETPEPGDAEGPDGHLATKQRPVARSKIKFTTGTCSDSVVHSCDLCGKGFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFDLKRHVRTHTGIRPYKCNVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDCGYTGPTQEDLYLHVNSAHPGSSFLKKTSKKLAALLQGKLTSAHQENTSLSEEEERK
Protein: Crossover junction endonuclease EME1 (EC 3.1.22.-) (Essential meiotic endonuclease 1) (OsEME1) (Q0J9J6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombination events that are insensitive to crossover interference (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MASHAAVVEIIDDDDDDDDDVAAASTPPALHKRSHAVAAAAPDSPDAFSPSPPDPKRRQLAASTIVLDDTPTPPKRRPPPVAADRSASVVADTPRSFVPCSLRNRAIAGDTPDSVLPSPSFHLDAPDSATPGSDVPCSVGLDDIVPETPGFNSPRLARPPAVPGLTSPMTARKFSGVSCPISLDSDDELDDTVYRESLTRTPSNMAKPEHAIQPCTTSCTDKVENTKSTDKKDYSKSNVGYQTNNSACKNNGTTSYNQPPRANSPCEDSTLKEADPFINNHCPQEENALPIEERKKKQQEEKRLKKEKKAREIEEKKQKRLETKKQKEAMKAELAELKKLEKEKKKWESGKLATKCIVAEIDSSVIESGSVGGHLVQGFHEKGLCFRVTSNSIKGSILWKMQIPNEFTQDQASTSQVPYILFVLQAEEFCDLVSGGTLLDHVQKVRRQYPEFTICYVTNKLMSFIKRREQNQYNKTTSNSNSWKRPPVEEALCKLATHYARVRSRHCTDEAEVTEHIVGLTYSLANCKFRKPLTWLSVHANGSNISKGCVDKDRIKKSAWLKSLVAIPGVSPGQAIAIEKKYPSMRSLLNVYMDDSKSVHEKEHLLEDLRLEGPLGDFKRRLGPACSKKVYTILMAQNGAAEVEVDRRGA
Protein: Pipsqueak protein (Q24455)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAVRGHQYFSLRWNNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHPTIILPADIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAEQLKIKGLCETAENADDLNDAATATITVSENIQQAVVGNIVNAAIVPGAPSPSLEQQQQHHQQQQQQQAQEQHQQQQVHAQQQQQQQQQINAALLTQHGVSSGSVSLSGQLLSSSASGSSGSLAGGQQASQTPSGLQPTPRKSRLKRSKSPDLSSGGGAGSSGGSSSGSTQQQPQPAHHHHPQTILIQGQNPNSIVSLQQTADGNYIPVSGSGDDSDAEDHEHEHNHGHGHGHGGHTHGHGHSHDHSHDHEHEHKPNKICKTEHSVASPASNSSSASNNAAGVSGVTSTGQAIVTQIVVARDGKDTKNMTSLGMGMVSWLASFGLVSKSQQISQLARDRSQIGSPQARMNINFANLTIPISLSTRIWIACRTAACWACPWDSWTSHPSHQHHLPPQSPSRSTSICPATLARTRAIYQIPPNRSI
Protein: Zona pellucida sperm-binding protein 1 (Zona pellucida glycoprotein 1) (Zp-1) [Cleaved into: Processed zona pellucida sperm-binding protein 1] (I6M4H4)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida (By similarity).
Subcellular location: [Processed zona pellucida sperm-binding protein 1]: Zona pellucida {ECO:0000269|PubMed:22842159}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48829}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Zona pellucida sperm-binding protein 3
- Growth/differentiation factor 9
- Zona pellucida sperm-binding protein 2
- NOBOX oogenesis homeobox
- Factor in the germline alpha
- NLR family pyrin domain containing 5
- Zonadhesin
- Bone morphotic protein 15
Sequence:
MTGGRLVALLLLVAASLGLGQQPHPEPGLPGLQYSYDCGMRGMQLVVLPRPGRTIRFKVVDEFGNRFEVNNCSICFHWVSAEPQAPAVFSADYKGCHVLEKEGHSHLTVFIEAMLPDGHVEVAQEAVLICPKPGHTWAVGSHQVPPTTPSPTTPHALPFHLSSAHTFPIPLYLEHSLMLPTPAGPSLGPGPTPAVLAQVERWEVDKPDAVGSHLPQEWCQVASGHIPCIVQSSSKEACEQAGCCYDSAREVPCYYGNTATVQCFRNGYFILVVAQEMALAHRITLANVHLAYAPTRCPPAQKTSAFVIFHVPLTHCGTTVQVLGSQLFYENQLVSDIDVREGPQGSITRDSSFRLLVRCIFNASDFLPIQASIFSPPLPAPVTQAGPLRLELRIARDETFSSFYEEEDYPLVRLLREPVHVEVRLLQRTDPSLVLELHQCWATPSANPVQQPQWPLLSDGCPFKGDSYRTRVLALDRAELPFRSHYQRFTVATFTFLDSGAQRALRGLVYFFCSASACHPSGPETCSSTCSSRTAKRRRSSGYHDGTPRALDIVSSPGPVGFQDSHRQEPTLESTGSGRNSNPKPLLWVVLLLLAIALVLGIGVFVGLSQAWAHKLREGHRLTDQAQ
Protein: Peptidyl-prolyl cis-trans isomerase CYP21-3, mitochondrial (PPIase CYP21-3) (EC 5.2.1.8) (Cyclophilin of 21 kDa 3) (Rotamase CYP21-3) (Q94A16)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase CYP21-1
- Peptidyl-prolyl cis-trans isomerase CYP18-2
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7
- At2g20330/F11A3.12
- At1g80930/F23A5_23
- Initiation factor eIF-4 gamma, MA3
- Peptidyl-prolyl cis-trans isomerase CYP23
- Peptidyl-prolyl cis-trans isomerase CYP40
- Peptidyl-prolyl cis-trans isomerase CYP59
Sequence:
MAKIKPQALLQQSKKKKGPSRISITNIVIYTLAVLLLVFVLFSAYRRWTHRSEIPTHNGRSVLEDAAFPGMKNVDLPRFATLDTGKGSVTIELFKDTAPNVVDQFMKFCQDGYFKGFLFSRVVKHFVIQAGDSAEFDAVKDWALDRKNIDTSLKHEEFMVGTPKAKNEQGGFEFFIVSAQIKDLNEKLTVFGRVSKGQDVVQEIEEVETDDQYQPKSPIEIMSVTLLQDM
Protein: Mitogen-activated protein kinase (EC 2.7.11.24) (Q38B88)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSEIEPHILRKYEIQAQLGQGAYGIVWRAIDRRTRQVVALKKIYDAFQNATDAQRTFREIMFLQALSHPNIIKLLHVHRATNDKDIYLVFEYMETDLHVVIRANILEDIHKQFIIYQLLKTMKYLHSAELLHRDMKPSNLLVNSDCSMKVADFGLARSILSLEKEQVARPVLTDYIMTRWYRPPEVLLGSTRYTKGVDMWAIGCILAELLLGRPIFPGRTTMKQLELIINVLGEPTAEEIRSTNSQFAEAMLKDTRRTQTTTFAELLPKAPPDALDLVQKLMRFNPNERLTAEQALEHPYVAAFHKPQDEPSAPAPITISLPDDTRFTMQEYRERLYQEIANARRKVRREVLGSGAPTRGTHSSLATGTASGTSEEKKENARVSSAATRPASSSAARTTATAGSSSGAGLHRTTVASRSAQHHTRPAVHRQPSGASRVLHK
Protein: Transcriptional regulator BrlR (HTH-type transcriptional regulator BrlR) (MerR-like regulator BrlR) (biofilm resistance locus regulator) (Q9HUT5)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable Resistance-Nodulation-Cell Division
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit omega
- RNA polymerase sigma factor RpoS
- RNA polymerase sigma factor RpoD
- RNA polymerase sigma factor RpoH
- DNA-directed RNA polymerase subunit beta'
- P-type Cu
- Haem-oxygenase-associated N-terminal helices domain-containing protein
Sequence:
MLTIGQLARIFEISTKTLRHYDAIGLFVPARTGSDNGYRYYQPEQIEQLSRILALRRLDVPLEAIDRLKRDGALDDPQRLRHFLQRHQHTLREEISARQRLLAELDRTLATLAHWRIRNMHARIVERPAFSVVGMEYFGSAPGDTIGQLWERFIPREHEIAGKHDPEVSYGICAQQPNGEFHYVAGFEVQEGWPVPEGMVRFQVPAQKYAVFTHKGTAPQIAESFQAIYSHLLAERGLEPKAGVDFEYYDQRFRGPLDPNSQVDLYIPIY
Protein: CG13178 (IP09550p) (Q29QP4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Beta-sarcoglycan
Sequence:
MLYVIDQRLKAQQIAQDKSVQVIHDVTSVLLEPKFIDSLLNGSKHNSAQLLTAEHCKFMLNDIATCSLMRLDEQSMSKLWNLMTMVYKWQLFVSRHQHHLLEITFRHLEAINRLYPDAKRHMLIDFTKNTLLDFWNASGEDAQLSIYQTNRAWLQCFNTKISLLIRMGFQAMDGSFIRDVDQDYYAEYVESAGDNIYAKSADQRERQQREPNSMDQLAAQLNINPAQSEDLQPINARQFQQQFEQAFGNVLFNDTAASSSGCEFVQLQPTTSASSSEKVATSMSRGGSLLNQNLLDLYSKMP
Protein: Rifin (O96293)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKLHFPKILLFFFPSNILLTSYHVHSKNKPYITPRHTPTITSRVLRECDIHKSIYDNDEDMKSVKENFDRQISQRFEEYEERMKGKRQKRKEERDKNIQEIIEKDRMDKSLAEKVEKCCLICGCGLGGVAASVGIFGGIAISELKKAAMIAAIASAQKTGVLAGEAARIPAGIKAVIAGLKRMGISTLGGKDLGSYFATTDYTNFKTIARVINSEYQTDSCLIGGPATDKSKTICNWVRANFVAPQDSPGKGGSVYKSIETAVKSIVTDAETVAQRAVENATEEVIKNSTAAAESTYAGCQTAIIASVVAIIIIALVMIIIYLVLRYRRKKKMKKKAEYTKLLNQ