wanglab/gogpt-training-data huggingface dataset:
Protein: Tubulin-tyrosine ligase (Q386R8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MMKDFEAFSRVLADWFVVHSVPQHLQRSLFEKLVNDVFDAGTSFSLAVVAREDEDEVDAEDQSSETAGNYVLVASKNLKANDDIWLIDHCCTFRLRDFRAHLEANEALRTRLGRVLAVNLSGADNRHGAQLIFDHMWNKVGSYRLPTSADGDDSQYESYWFIHDEVGSAITTVVNEKANMKLEPIPICFPEKGGVFSAMWCVEDMEEEEVATRRAASTLEATSGKEILSLIYNTRHEEETEEDPYRSAQLLCVEAWRRLVKRLESVPGRRAQREQSALAPVERCPSGPLRVFTDSQQLSQNLTDANHFVVVDLPQEAHIVWVVHHSIEGLNDYGHAQYISQFPEESEFTSKQGLLRLIQETYGYVDWYQTSYDSTTQLKELIGDFIVRKAALDKKIDTDPLVTYEDIGKLRSNDGTNLWISKPTNLARSIDMTLSSNLTELLRAVETGPKVICKYIANTATLRKRKFDLRFIVAVNSFTSEHSSSMEAYVYNTFWTRFALKEYSLDDFDCYEKHWTVMNYTNPEALLQLHDHDFVKEFNEEYASSGYGEAAWEKIAYPKILKMLREAFGMVVTRGGDHSRCRAMYGVDVMLRTERCVETGALTLEPSLLEITFSPDCRRACKYHPTFFNDIFHTLFLRDPTNMTPL
Protein: Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) (P40855)
Organism: Homo sapiens (Human)
Function: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:15007061}. Peroxisome membrane {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:15007061, ECO:0000269|PubMed:27181750, ECO:0000269|PubMed:9339377}; Lipid-anchor {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:9339377}; Cytoplasmic side {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:9339377}. Note=Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes. {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:15007061}.
Interaction partners:
- Peroxisomal biogenesis factor 3
- Peroxisomal membrane protein PEX16
- Peroxisomal membrane protein PEX13
- Peroxisomal membrane protein PEX14
- Peroxisomal membrane protein 11B
- Peroxisome assembly protein 12
- Peroxisome biogenesis factor 10
- ATP-binding cassette sub-family D member 3
- Peroxisome biogenesis factor 2
- Peroxisome assembly protein 26
Sequence:
MAAAEEGCSVGAEADRELEELLESALDDFDKAKPSPAPPSTTTAPDASGPQKRSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDMTSQQEFTSCLKETLSGLAKNATDLQNSSMSEEELTKAMEGLGMDEGDGEGNILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHRESLPPEQFEKYQEQHSVMCKICEQFEAETPTDSETTQKARFEMVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDALNLSGPPGASGEQCLIM
Protein: Uracil phosphoribosyltransferase homolog (A0A494C0H3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD
Protein: Leucine-rich repeat receptor-like protein kinase (Leucine-rich repeat transmembrane protein kinase family protein) (Receptor kinase-like protein) (Q9FLL2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046288}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00046288}.
Interaction partners:
Sequence:
MRLYLSSTMQLSLMSLVLGFLFVSCDAFASKEVEAVRRFKEAIYKDPLLVMSNWNVPNLSPCDWNGIKCSPSKDHIIKINISGTSMRGFLVPELGQITYLQELILRGNILMGTIPKEIGKLKKLKILDLGNNHLTGPIPAEIGKLSRIKTINLQSNGLIGKLPPEIGNLKHLKELLIGRNRLRGSIPIAAKTSKKYASNPSANISGLCKSSLFKVADFSYNFFEGRVPSCLDYLPITSFQGNCMKTMDVKQRPLSECARLAVTVAKKKHRASRQTWLRNFEIVTGSSVGLLFLVVMFSACSLCKIKRSLIVPWKKSASEKEKFTVYVDSEMLKDVSRYTRQELEVACEDFSNIIDSSAESQIYKGTIKGGTEIAVISLCVKEENWTGYLELNFQREVAALARLNHENAGKLLGYCKESTPFTRMLVFEYASNGTLYDHLHYADGSLVSWAKRMKIVIGIARGLKYLHTELHPPFTVSELSSTAVYLTEDFTPKLVDFECWKIIQVRSEKNLKNICNEGAICVLPNAMEHRDMDLQGNIYSFGILLLEIVSGRPSYCQDRGCLVEWVREKNLGAPDVMASLVDPELKHFKQKELEAVCEVASQCLNLDQNEKDKDKLSCSIQALCETLESRITVSISAEFKSSSLAWAELALASPSNEDDDDRSK
Protein: Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) (Q96RS0)
Organism: Homo sapiens (Human)
Function: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12943661}. Nucleus, Cajal body {ECO:0000305|PubMed:12032086}. Nucleus, nucleolus {ECO:0000269|PubMed:12032086}. Note=A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network. {ECO:0000269|PubMed:12943661}.
Interaction partners:
- Small nuclear ribonucleoprotein F
- Nuclear receptor coactivator 6
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein-associated proteins B and B'
- Histone acetyltransferase p300
- Pre-mRNA-splicing factor CWC22 homolog
- Mediator of RNA polymerase II transcription subunit 1
- rRNA 2'-O-methyltransferase fibrillarin
Sequence:
MCCEKWSRVAEMFLFIEEREDCKILCLCSRAFVEDRKLYNLGLKGYYIRDSGNNSGDQATEEEEGGYSCGTAESHDSKGIGLDESELDSEAELMRSMGLPLQFGRITAHKDFEVSMNTRNKVKIKKKKHQKKYLDEIVQESWRKEYEEDDILASDDPSSIEQYENTRTYELQSKKDTETENPPVENTLSPKLEITEKWEKYWNEYGGGLLWQSWQEKHPGQALSSEPWNFPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFDASQSCDTDTYTSKTEADDKNDEKCMKVDLVSFPSSPIMVDNDSSGTSDKDHSEILDGISNIKLNSEEVTQSQLDSCTSHDGHQQLSEVSSKRECPASGQSEPRNGGTNEESNSSGNTNTDPPAEDSQKSSGANTSKDRPHASGTDGDESEEDPPEHKPSKLKRSHELDIDENPASDFDDSGSLLGFKYGSGQKYGGIPNFSHRQVRYLEKNVKLKSKYLDMRRQIKMKNKHIFFTKESEKPFFKKSKILSKVEKFLTWVNKPMDEEASQESSSHDNVHDASTSSDSEEQDMSVKKGDDLLETNNPEPEKCQSVSSAGELETENYERDSLLATVPDEQDCVTQEVPDSRQAETEAEVKKKKNKKKNKKVNGLPPEIAAVPELAKYWAQRYRLFSRFDDGIKLDREGWFSVTPEKIAEHIAGRVSQSFKCDVVVDAFCGVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLLASFLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSKKITNNIVYFLPRNADIDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRPASET
Protein: GTP-binding nuclear protein spi1 (P28748)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export.
Subcellular location: Nucleus.
Interaction partners:
- Exportin-T
- Ran GTPase-activating protein 1
- Exportin-1
- Protein pim1
- Ran-specific GTPase-activating protein 1
- Uncharacterized protein C328.01c
- Importin subunit beta-1
- Nuclear import protein mog1
- Nuclear transport factor 2
- Probable importin c550.11
Sequence:
MAQPQNVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLHFHTNFGEICFNVWDTAGQEKLGGLRDGYYIQGQCGIIMFDVTSRITYKNVPHWWRDLVRVCENIPIVLCGNKVDVKERKVKAKAITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPNLEFVASPALAPPEVQVDQQLLAQYQQEMNEAAAMPLPDEDDADL
Protein: Hydrogenase-2 large chain (HYD2) (EC 1.12.99.6) (Membrane-bound hydrogenase 2 large subunit) (NiFe hydrogenase) (P0ACE0)
Organism: Escherichia coli (strain K12)
Function: This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake.
Subcellular location: Cell membrane; Peripheral membrane protein.
Interaction partners:
- Hydrogenase-1 small chain
- Hydrogenase-2 small chain
- Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit
- Hydrogenase-2 operon protein HybA
- Hydrogenase 2 maturation protease
- Hydrogenase maturation factor HybG
- Hydrogenase-2 operon protein HybE
- Hydrogenase maturation factor HybF
- Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit
- Hydrogenase 1 maturation protease
Sequence:
MSQRITIDPVTRIEGHLRIDCEIENGVVSKAWASGTMWRGMEEIVKNRDPRDAWMIVQRICGVCTTTHALSSVRAAESALNIDVPVNAQYIRNIILAAHTTHDHIVHFYQLSALDWVDITSALQADPTKASEMLKGVSTWHLNSPEEFTKVQNKIKDLVASGQLGIFANGYWGHPAMKLPPEVNLIAVAHYLQALECQRDANRVVALLGGKTPHIQNLAVGGVANPINLDGLGVLNLERLMYIKSFIDKLSDFVEQVYKVDTAVIAAFYPEWLTRGKGAVNYLSVPEFPTDSKNGSFLFPGGYIENADLSSYRPITSHSDEYLIKGIQESAKHSWYKDEAPQAPWEGTTIPAYDGWSDDGKYSWVKSPTFYGKTVEVGPLANMLVKLAAGRESTQNKLNEIVAIYQKLTGNTLEVAQLHSTLGRIIGRTVHCCELQDILQNQYSALITNIGKGDHTTFVKPNIPATGEFKGVGFLEAPRGMLSHWMVIKDGIISNYQAVVPSTWNSGPRNFNDDVGPYEQSLVGTPVADPNKPLEVVRTIHSFDPCMACAVHVVDADGNEVVSVKVL
Protein: Transmembrane protein (F4K5N0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Inorganic pyrophosphatase 2
- Monogalactosyldiacylglycerol synthase 3, chloroplastic
- At1g20770
- Purple acid phosphatase 17
- SPX domain-containing protein 3
- Sulfoquinovosyl transferase SQD2
- Inorganic pyrophosphatase 1
- Putative F-box protein PP2-B6
- Putative U-box domain-containing protein 50
- Cyclin-U4-3
Sequence:
MSTLESPLEALAFEYASLGVFAVVNNVWTWIAVVTAAVSFWRIRVTTIGVGDGHACVLIEELTGSKSENESGRLEPKSITGPVKETVARVKETVTKTEPLICDDGVTKGKLTMCYEVDVDVDGGRCVNGDLTAVSYGGGLGNCGGDWWEKWDGVVRMRNGDDSWYRYVDLTVINGNVVRLWDDNKTLVTAACV
Protein: Nuclear receptor subfamily 2 group F member 5 (Steroid receptor homolog SVP 46) (Q06726)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Putative receptor that is required in photoreceptor cells precursors during eye development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
Sequence:
MAMVVNQWQENISADPGSQLQMCSQEPGGTPGTPSGSTPGNDALSGDKIPNVDCMVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRGNRDCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMSNSQSSPGQYLSNGSDPYNGQPYLSGFISLLLRAEPYPTSRYGAQCMQSNNLMGIENICELAARLLFSAVEWAKNIPFFPDLQLMDQVALLRMSWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSAERVVAFMDHIRVFQEQVEKLKALQVDTAEYSCLKSIVLFTSDAMGLSDVAHVESIQEKSQCALEEYVRNQYPNQPNRFGRLLLRLPSLRIVSSPVIEQLFFVRLVGKTPIETLLRDMLLSGSSYNWPYMPVQRDRPISIHYNENGP
Protein: Protein DDI1 homolog 2 (EC 3.4.23.-) (Q5TDH0)
Organism: Homo sapiens (Human)
Function: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity.
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:27528193}. Chromosome {ECO:0000269|PubMed:29290612}.
Interaction partners:
- Regulatory solute carrier protein family 1 member 1
- Polyubiquitin-C
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-B
- UV excision repair protein RAD23 homolog B
- UV excision repair protein RAD23 homolog A
- 26S proteasome non-ATPase regulatory subunit 14
- 26S proteasome non-ATPase regulatory subunit 2
- Endoplasmic reticulum membrane sensor NFE2L1
- Peptide-N
Sequence:
MLLTVYCVRRDLSEVTFSLQVDADFELHNFRALCELESGIPAAESQIVYAERPLTDNHRSLASYGLKDGDVVILRQKENADPRPPVQFPNLPRIDFSSIAVPGTSSPRQRQPPGTQQSHSSPGEITSSPQGLDNPALLRDMLLANPHELSLLKERNPPLAEALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFDLEAQAKIEEDIRQQNIEENMTIAMEEAPESFGQVVMLYINCKVNGHPVKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQIEGDFLPCSFSILEEQPMDMLLGLDMLKRHQCSIDLKKNVLVIGTTGSQTTFLPEGELPECARLAYGAGREDVRPEEIADQELAEALQKSAEDAERQKP
Protein: ATP-dependent RNA helicase Ddx1 (DEAD box protein 1) (EC 3.6.4.13) (Q9VNV3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity (By similarity).
Interaction partners:
- RNA-splicing ligase RtcB homolog
- RE59232p
- Protein FAM98B
- ATP-dependent RNA helicase DHX15 homolog
- Protein archease-like
- Bifunctional glutamate/proline--tRNA ligase
- 26S proteasome regulatory subunit 4
- COP9 signalosome complex subunit 3
Sequence:
MTAFEEFGVLPELGMATDELDWTLPTDVQAEAIPLILGGGDVLMAAETGSGKTGAFCLPILQIVWETLRDLEEGKAGKGGAIGGAVTPWTMSFFDRGNALAVTPDGLRCQSREFKEWHGCRATTGVRGKGKFYFEATVTDEGLCRVGWSTQQANLDLGTCRMGFGFGGTGKKSNNRQFDDYGEAFGKADVIGCLLDLKNQEVSFTKNGQNLGVAFRLPDNLAKETFYPAVVLKNAEMQFNFGKTDFKYAPGNGFVGACQAGPEHSKANPITGPAAGAPSAKPAPNAPQAIIMEPSRELAEQTYNQIEKFKYHLSNPEVRSLLLIGGVRLEEQKAQLMQGTHIVVGTPGRLEEMINSGLVLLTHCRFFVLDEADALLKQGYTELIDRLHKQIPKITSDGRRLQMVVCSATLHAFEVKKMAERLMHFPTWVDLKGEDAVPETVHHVVCLVDPQMDTTWQSLRQPIGTDGVHDRDNVHPGNHSKETLSQAVKLLKGEYCVHAIDKHNMDRAIIFCRTKQDCDNLERFLRQRGGKHYSCVCLHGDRKPQERKENLEMFKRQQVKFLICTDVAARGLDITGLPFMINVTLPDDKTNYVHRIGRVGRAERMGLAISLVATVPEKVWYHGEWCKSRGRSCNNTNLTEVRGCCIWYNEPNLLAEVEDHLNITIQQVDKTMDVPVNDFDGKVVYGQKNLRTGSGYEDHVEQLVPTVRKLTELELQSQSLFLKRLKV
Protein: Small ribosomal subunit protein uS5m (28S ribosomal protein S5, mitochondrial) (MRP-S5) (S5mt) (P82675)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25838379}.
Interaction partners:
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS15m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein bS16m
Sequence:
MATAVRAVGCLPVLCSGTAGHLLGRQCSLNTLPAASILAWKSVLGNGHLSSLGTRDTHPYASLSRALQTQCCISSPSHLMSQQYRPYSFFTKLTADELWKGALAETGAGAKKGRGKRTKKKKRKDLNRGQIIGEGRYGFLWPGLNVPLMKNGAVQTIAQRSKEEQEKVEADMIQQREEWDRKKKMKVKRERGWSGNSWGGISLGPPDPGPCGETYEDFDTRILEVRNVFTMTAKEGRKKSIRVLVAVGNGKGAAGFSIGKATDRMDAFRKAKNRAVHHLHYIERYEDHTIFHDISLRFKRTHIKMKKQPKGYGLRCHRAIITICRLIGIKDMYAKVSGSINMLSLTQGLFRGLSRQETHQQLADKKGLHVVEIREECGPLPIVVASPRGPLRKDPEPEDEVPDVKLDWEDVKTAQGMKRSVWSNLKRAAT
Protein: Movement protein (30 kDa protein) (Cell-to-cell transport protein) (P69513)
Organism: Tomato mosaic virus (strain L) (ToMV) (TMV strain tomato)
Function: Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Forms a ribonucleoprotein complex with viral RNA (By similarity). Triggers host hypersensitive defense reaction in incompatible tomato plants harboring Tm-2, Tm-2nv or Tm-2(2) ToMV resistance (R) proteins.
Subcellular location: Host cytoplasm, host cytoskeleton {ECO:0000305|PubMed:15290376}. Host cell junction, host plasmodesma {ECO:0000269|PubMed:23148080, ECO:0000305|PubMed:15290376}. Note=Binds to the host cytoskeleton before being transported to the host plasmodesmata (Probable). Observed in virus replication complexes (VRCs) of tobamovirus infected host cells (PubMed:23148080). In resistant plants, targeted to the host plasma membrane via the interaction with host resistance (R) protein TM-2. {ECO:0000250|UniProtKB:P03583, ECO:0000269|PubMed:23148080, ECO:0000305|PubMed:15290376}.
Interaction partners:
Sequence:
MALVVKGKVNINEFIDLSKSEKLLPSMFTPVKSVMVSKVDKIMVHENESLSEVNLLKGVKLIEGGYVCLVGLVVSGEWNLPDNCRGGVSVCMVDKRMERADEATLGSYYTAAAKKRFQFKVVPNYGITTKDAEKNIWQVLVNIKNVKMSAGYCPLSLEFVSVCIVYKNNIKLGLREKVTSVNDGGPMELSEEVVDEFMENVPMSVRLAKFRTKSSKRGPKNNNNLGKGRSGGRPKPKSFDEVEKEFDNLIEDEAETSVADSDSY
Protein: Uncharacterized oxidoreductase C1739.08c (EC 1.-.-.-) (O74470)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized oxidoreductase C22A12.17c
- Sorbose reductase sou1
Sequence:
MSTPPANVTTAHVLDLFSLKGKNCVVFGAAKGIGFSIATAFAQAGGNVIITYLTTDPTEKAKKLAEETGVQVHTLKIDISRSDTVEAGVEEIQKIFKEIHVVVANAGMPFRRSVLDSPPHEFEKVMNINTNSVYRVAYYMGKIFKKQGFGNLIATASMSATIVNAPQHIAAYCASKAAVRQLCKALAVEWAEFARINSVSPGYFATDMPGYEFLKQWEPYVPFKRLGLTPELRGTYLYLASNASSFVTGLDLIVDGGYTCL
Protein: Glycerophosphoinositol transporter 1 (P25346)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Glycerophosphodiester transporter that mediates uptake of both glycerophosphoinositol (GroPIns) and glycerophosphocholine (GroPCho) as sources of the nutrients inositol and phosphate.
Subcellular location: Cell membrane {ECO:0000305|PubMed:12912892, ECO:0000305|PubMed:16141200, ECO:0000305|PubMed:9691030}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glycerophosphocholine phosphodiesterase GDE1
- Glycerophosphocholine acyltransferase 1
Sequence:
MEDKDITSVNEKEVNENTNPRIIKYDAERRATRTETSKKDKWKNIVTIIASGFALISDGYVNGSMSMLNKVFVMEYGKKNYSSKVSTRVSNAALVGIIFGQFFMGIAADYYSRKSCILVATAILVIGSALCAASHGTTVPGMFWMLTVMRGLVGIGVGAEYPTSTLSANESANEYTTTKRGGILVMVTNLPLAFGGPFATIIFLIVYKICSGTKHLEAIWRTVFAIGCFWPLSVFYFRWKTATTEVYEKGRIKRNIPYFLALKFYWKRLLGTCGTWFMYDFVTFPNGIFSSTIISSVIKDQNDLVKVAEWNLLLGVLAVLGVPIGAYLSDRIGRKYTLMFGFSGYIIFGLIIGCAYDQLKKITPLFIIFYAFMNMLGNAGPGDMLGVISSEASATAVRGVFYGLSAVTGKIGSVVGVECFQPIRDNLGARWTFIIAAICGLIGIIITYFFVPHSLESDLMKQDVEFHNYLVSNGWTGKMGFDETDEESMVRTIEVEENGTNCSKKNAEIISVRQVDQS
Protein: [PSI+] inducibility protein 3 (LAS seventeen-binding protein 2) (LAS17-binding protein 2) (Q06449)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Overproduction promotes the de novo induction of the [PSI+] prion form of SUP35. The prion-inducing effect depends on the association with the actin cytoskeleton. Also implicated in prion maintenance during heat stress.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:21777813}. Note=When overexpressed, localizes to punctate structures which are reminiscent of cortical actin patches (PubMed:21777813). Transiently colocalizes with SUP35 aggregates during prionogenesis (PubMed:21777813). {ECO:0000269|PubMed:21777813}.
Interaction partners:
- Proline-rich protein LAS17
- LAS seventeen-binding protein 1
- Eukaryotic peptide chain release factor GTP-binding subunit
- Myosin tail region-interacting protein MTI1
- Protein BZZ1
- E3 ubiquitin-protein ligase RSP5
- Mitogen-activated protein kinase KSS1
- [PIN+] prion protein RNQ1
- [PSI+] induction protein 2
Sequence:
MSASLINRSLTNIRTELDFLKGSNVISNDVYDQINKSLPAKWDPANAPRNASPASLEYVEALYQFDPQQDGDLGLKPGDKVQLLEKLSPEWYKGSCNGRTGIFPANYVKPAFSGSNGPSNLPPPPQYKAQELQQIPTQNSAASSYQQQPFPPPSTNYYQQPQQQPQQAPPPQQQQQQQQHQSSHSHLKSFGSKLGNAAIFGAGASIGSDIVNNIF
Protein: Polyprotein (O89168)
Organism: Hepacivirus hominis
Interaction partners:
Sequence:
SGSWLKDVWDWICTVLTDFKTWLQSKLLPKLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPKTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEITRVGDFHYVTGMTTDNVKCPCQVPAPEFFTELDGVRLHRYAPACRPLLRVDVTFQVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRPARGSPPSLASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVAAEILRKSKNFPPALPIWARPDYNPPLLESWKSPDYVPPAVHGCPLPPTTGPPIPPPRKKRTVVLTESTVSSALAELATKTFGSSGSSAVDSGTATAPPDQTSDDGDKESDIESYSSMPPLEGEPGDPDLSDGSWSTVSGEAGDDVVCC
Protein: Precursor of CEP6 (PCEP6) [Cleaved into: C-terminally encoded peptide 6.1 (CEP6.1) (CEP6a); C-terminally encoded peptide 6.2 (CEP6.2) (CEP6b)] (B3H5A9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signaling peptide that represses primary root growth rate. Modulates leaf morphology. Regulates systemic nitrogen (N)-demand signaling. Mediates up-regulation of genes involved in N uptake and assimilation pathways.
Subcellular location: [C-terminally encoded peptide 6.2]: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:25324386}. Note=Accumulates in xylem sap under nitrogen (N)-starved conditions. {ECO:0000269|PubMed:25324386}.; SUBCELLULAR LOCATION: [C-terminally encoded peptide 6.1]: Secreted, extracellular space, apoplast {ECO:0000305|PubMed:25324386}. Note=Accumulates in xylem sap. {ECO:0000305|PubMed:25324386}.
Interaction partners:
- Precursor of CEP15
- Precursor of CEP8
- Precursor of CEP14
- Precursor of CEP4
- Precursor of CEP7
- Precursor of CEP13
- Protein IDA-LIKE 5
- Precursor of CEP11
- Protein IDA-LIKE 4
- Precursor of CEP5
Sequence:
MKLSVYIILSILFISTVFYEIQFTEARQLRKTDDQDHDDHHFTVGYTDDFGPTSPGNSPGIGHKMKENEENAGGYKDDFEPTTPGHSPGVGHAVKNNEPNA
Protein: Nicastrin (Q92542)
Organism: Homo sapiens (Human)
Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
Subcellular location: Membrane {ECO:0000269|PubMed:10993067, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:26776682}; Single-pass type I membrane protein {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10993067}; Single-pass type I membrane protein {ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25918421, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Interaction partners:
- Gamma-secretase subunit APH-1A
- Presenilin-1
- Gamma-secretase subunit APH-1B
- Gamma-secretase subunit PEN-2
- Presenilin-2
- Amyloid-beta precursor protein
- Transmembrane emp24 domain-containing protein 10
- Neurogenic locus notch homolog protein 1
- Acylamino-acid-releasing enzyme
- Rhomboid-related protein 2
Sequence:
MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
Protein: Prostatic steroid-binding protein C2 (Prostatein peptide C2) (P02781)
Organism: Rattus norvegicus (Rat)
Function: Part of prostatein which is the major secretory glycoprotein of ventral prostate gland.
Subcellular location: Secreted.
Interaction partners:
- Cystatin-related protein 2
Sequence:
MRLSLCLLTILVVCCYEANGQTLAGQVCQALQDVTITFLLNPEEELKRELEEFDAPPEAVEANLKVKRCINKIMYGDRLSMGTSLVFIMLKCDVKVWLQINFPRGRWFSEIN
Protein: Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1) (Q61152)
Organism: Mus musculus (Mouse)
Function: May be involved in growth and differentiation of hematopoietic cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:8977243}. Cytoplasm {ECO:0000269|PubMed:8977243}.
Interaction partners:
- 4-hydroxyphenylpyruvate dioxygenase
- Proline-serine-threonine phosphatase-interacting protein 1
Sequence:
MSRHTDLVRSFLEQLEARDYREGAILAREFSDIKARSVAWKSEGVCSTKAGSRLGNTNKNRYKDVVAYDETRVILSLLQEEGHGDYINANFIRGIDGSQAYIATQGPLPHTLLDFWRLVWEFGVKVILMACQETENGRRKCERYWAREQEPLKAGPFCITLTKETTLNADITLRTLQVTFQKEFRSVHQLQYMSWPDHGVPSSSDHILTMVEEARCLQGLGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFQVVLEMRKQRPAAVQTEEQYRFLYHTVAQLFSRTLQDTSPHYQNLKENCAPICKEAFSLRTSSALPATSRPPGGVLRSISVPAPPTLPMADTYAVVQKRGASAGTGPGPRAPTSTDTPIYSQVAPRAQRPVAHTEDAQGTTALRRVPADQNSSGPDAYEEVTDGAQTGGLGFNLRIGRPKGPRDPPAEWTRV