wanglab/gogpt-training-data huggingface dataset:
Protein: OTU domain-containing protein 4 (EC 3.4.19.12) (B2RRE7)
Organism: Mus musculus (Mouse)
Function: Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q01804}. Nucleus {ECO:0000250|UniProtKB:Q01804}. Note=Primarily cytoplasmic. {ECO:0000250|UniProtKB:Q01804}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 7
- Nuclear pore complex protein Nup153
- E3 ubiquitin-protein ligase RNF216
Sequence:
MEAAVGAPDGVDQGGVGPLEDETPMDAYLRKLGLYRKLVAKDGSCLFRAVAEQVLHSQSRHVEVRMACIRYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFVIYQEPNVSPSHVTENNFPEKVLLCFSNGNHYDIVYPITYKDSSAMCQSLLYELLYEKVFKTDVSKIMMGLEASEVAEESNSEISDSEDDSCKSKSTAATDVNGFKPSGSENPKNNGNSADLPLSRKVLKSLNPAVYRNVEYEIWLKSKQAQQKRDYSIAAGLQYEVGDKCHQVRLDHNGKLSNADIHGVHSENGLVLSEELGKKHTPKNLKPPPPESWNTVSGKKMKKPNSGQNFHSDTDYRGPKNLNKPIKAPSALPPRLQHPSSGVRQHAFSSHSTGSQSQKSSSEHKNLSRMPSQITRKPDRERAEDFDHVSRESYYFGLSPEERREKQAIEESRLLYEIQNRDEQAFPALSSSSVSQSPSQNSNACVPRKSSHARDRKGSMRRADAEERKDKDSLRGHTHVDKKPEPSTLEISDDKCTRVSSPSKSKKECPSPVEQKPAEHIPLSNPAPLLVSPEVHLTPAVPSLPATVPAWPSEPTTFGPTGVPAQIPILSVTQTTGPDAAVSQAHLTPSPVPVSIQAVNQPLMPLPQTMSLYQDPLYPGFPCSEKGDRAIAPPYSLCQTGEDLPKDKNILRFFFNLGVKAYSCPMWAPHSYLYPLHQAYMAACRMYPKVPVPVYPQNTWFQEAPPAQSESDCPCTDAHYSLHPEASVNGQMPQAEMGPPAFASPLVIPPSQVSEGHGQLSYQPELESENPGQLLHAEYEESLSGKNMYPQQSFGPNPFLGPVPIAPPFFPHVWYGYPFQGFVENPVMRQNIVLPPDDKGELDLPLENLDLSKECDSVSAVDEFPDARVEGAHSLSAASVSSKHEGRVEQSSQTRKADIDLASGSSAVEGKGHPPTQILNREREPGSAEPEPKRTIQSLKEKPEKVKDPKTAADVVSPGANSVDRLQRPKEESSEDENEVSNILRSGRSKQFYNQTYGSRKYKSDWGSSGRGGYQHVRGEESWKGQPNRSRDEGYQYHRHVRGRPYRGDRRRSGMGDGHRGQHT
Protein: Protein spaetzle 4 (Protein spatzle 4) (Q9VKG9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RE45222p
- Neurotrophin 1
- Protein spaetzle 5
- Protein spaetzle
Sequence:
MVRTQMDRRSPITRLITIEVIGYLLILMTIALPLSSAGFGFDSANSCSPNGKISRRGRAQILAAIPCDLGQQAFCHLPGSAYPWHAVRRFVHENQGLMKRMYGDVRHISILRDEIQNNEVDADDIEETAERYSKDGGRRSAKYLMNNRDRDREREDFGSFKSNDVLMEPHFRPVSTITTSTTKATTTTTTAPEIVSSTTERVPNEVTDTTPGNTNSTISTTKGTAPPLHEKPESETDIVEIQPSPESNSVYEVVSPSVLSTTSTAKPSSAAGENIQIIDSPQLGLRNLSAEASPSQEPPTATTGKPTSVPKSTTPLPIRKRKPAETTTSAASPKVSSTISTPTTTTATLLIRRNVTKYSPASVTTPVSFASLFSGTSSGLFSPERLRRPLTTTSSTSAPASSPPAGGTPASSSTGSASKSGLLREGQLFQDAMKQEPVAVASNLRGVNACPVKDEVVAPFWANNTRGEVLALLNLYPFEQYVHWEKCTHEFKQMFCRDGCRCEQQYRLHRLLAYDPHNECRGIFSDWFRFPSSCICKCYNIPMEFRATSRSPRSDSRFDAPKSDPIEAAEAEVQRAIYEHATEEWYRPRDEFDFLED
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (F4IKR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU361136}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU361136}.
Interaction partners:
Sequence:
MVKSTSKDAQDLFHSLHSAYTATPTNLKIIDLYVCFAVFTALIQQVAYMALVGSFPFNSFLSGVLSCIGTAVLAVCLRIQVNKENKEFKDLAPERAFADFVLCNLVLHLVIINFLG
Protein: Spermatogenesis-associated protein 7 homolog (Fertility-related protein WMP1) (Rat sperm DNA no.3) (RSD-3) (Q9R0A3)
Organism: Rattus norvegicus (Rat)
Function: Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). Required for photoreceptor-specific localization of proximal connecting cilium (CC) proteins RPGR, AHI1, NPHP1, NPHP4, and RPGRIP1 at the distal CC, a photoreceptor-specific extension of the primary cilium transition zone (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9P0W8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9P0W8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9P0W8}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q80VP2}. Note=Localizes to the microtubule network. {ECO:0000250|UniProtKB:Q9P0W8}.
Interaction partners:
- RD3 regulator of GUCY2D
- X-linked retinitis pigmentosa GTPase regulator
- Aryl-hydrocarbon-interacting protein-like 1
- NADP-retinol dehydrogenase
- Centrosomal protein 290
- IQ calmodulin-binding motif-containing protein 1
- Inosine-5'-monophosphate dehydrogenase 1
- Tubby-like protein
Sequence:
MAVHYNKILSAKAAVDCSIPVSVNASIKYADQQRREKLRKELARCEKEFKLSKSAMQTNSKMNSKFFVNSLQRPSGEPQDQDVLIEERLTRYPSFSKSLIPSPEGLHLSLPESNKILMNGTQKYPSTAPPRYSGCGHGYDRRPRSAHQFQVVISKTPSGDLLEKHADLFSNNQSPFTPRTLKTEAKSFLSQYRYYTPAKRRRDFSDQRMEAETQTELSSFNSELGTAEKKSSKDSDVSIKQAPNYMRNGAEDKIAPLSLQGQNLAWDKSKDGILQPSSERAPCTQFSPDSKIYSDEEELLYLSFMENVTDEILKLGLFSNRFLERLFERHIRKNKHHLEEGKMRYLLHGLKVDLGCISEEEQNSFRIFNEFHFQKALTSRENRFINDTEAVNHHERQQYQEALNMLSSVPKDENKMFSFPGEFLLPAHKVKHSEGVIVQQVNDETDFEALPWDGNNPSVSDSFIDQETSVDVIEGDSDFEMVETSRELCCLSTSLSPSVPLPSIEGGSNHDKELSTLKIMEMSIED
Protein: Type I interferon 2 (B6UQB1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MCTMQSWTCLFLILCSMQSVCHCCDWIQHHFGHLSAEYLSQLEQMGGDITKQNAPVLFPTSLYRHIYDAEFEDKVRFLNETIYQIIKLFDGNRNRKSVTWDKKNLDDFLNILDRQFENLSSCVSPVVKPEKRLKRYFRNLNRKVLRKMNYSAEAWELIRKETKRHLQRLDILVGQMY
Protein: Leucine-rich repeat (LRR) family protein (F4HR88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell envelope {ECO:0000256|ARBA:ARBA00004196}.
Interaction partners:
Sequence:
MNSSFTLFIFTFVIFLQCLNPTGAATCHPDDEAGLLAFKAGITRDPSGILSSWKKGTACCSWNGVTCLTTDRVSALSVAGQADVAGSFLSGTLSPSLAKLKHLDGIYFTDLKNITGSFPQFLFQLPNLKYVYIENNRLSGTLPANIGALSQLEAFSLEGNRFTGPIPSSISNLTLLTQLKLGNNLLTGTIPLGVANLKLMSYLNLGGNRLTGTIPDIFKSMPELRSLTLSRNGFSGNLPPSIASLAPILRFLELGHNKLSGTIPNFLSNFKALDTLDLSKNRFSGVIPKSFANLTKIFNLDLSHNLLTDPFPVLNVKGIESLDLSYNQFHLNTIPKWVTSSPIIFSLKLAKCGIKMSLDDWKPAQTFYYDFIDLSENEITGSPARFLNQTEYLVEFKAAGNKLRFDMGKLTFAKTLTTLDISRNLVFGKVPAMVAGLKTLNVSHNHLCGKLPVTKFPASAFVGNDCLCGSPLSPCKA
Protein: Brother of ihog, isoform B (Brother of ihog, isoform E) (Brother of ihog, isoform F) (FI05294p) (Q9W4Y6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAEIRLVVVLLVLMTTCIYTLQASDSNSSVATTLGVLFERAPESAVAPKGDEVVFECELNLKPDRLEWRFRRGDSSEPYLYLRPSAGYNVTSGSDGLAWRLRIYVSAQTAGDYQCVAWYGPGALASTPARLALVSIALDVGQGSMGARSSIRWSVAPKNCLLIRCGSVISNPPAIWSFYRNGKKLPQSELLPGAAGALVLDTVTAKDAGNYSCVATNSITGDELRLPQTIELRVDYTDRTPPYFLQRPPIEYSARPGETVVLECPGVGSPRPRVIWSSPNVVEIYNNRSTILSYGLQITDVKPEDQGSYICMLDNGIAPPIDHTIKLSVLQRPTILRGPAATLTNESNPLLLDCSASGNPQPDIYWLINGEDATKDPEAVVDNRSLQLKRVQKRHAGVVQCFAKNILGETSEGNILRVNPLEITGEDDEPLGEVPVWPVHESNTGMGTSSTSGGSKNKSGRRKFKASMVPPSRPNVTRLSDESVMLRWSVPQNSGLQITFFKVQYRMLGDGKNRRKNWQTTSDNIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFTSSVTGLTAGKYYRFRIVAVYSNNDNKEGNTSLKFFLQNGTSKSNLPVPELREVETLSESAVVLHWSLVSSTQNEDIDGYYAYYRPADSAAEYLKATVDGGMSRSFKIDLLRPGTPYEFKLQSFNSDAASEFSAIRQARTRKTHEQPASSSATPVPANKAVEQHQNSLYPLIAGAAGGGILLLIASLVVCLCLKRRENSQPEDENKPQLEHIQADFVTSAVLGVGGHHKSGDVRRLNGVIPRMNITPNPLAQETASDKNNSGLHQNGLHHAQPYHPPGTPTLMHKRLDYHQQPPPVPPHSAYYQQAPTHQPSPMMERSVRGHQQPGGFHMEEGTPTPTRIPSLRRQRRTSGNQQVHNSHSNLNIGLSHHNNNNNNLPPHHQHLHHHPGHPGGLVGIPIVPGSPRVQRSPMPSRAMIKRTRLGSHTDNISSGSLNSIEV
Protein: Mannose-1-phosphate guanylyltransferase catalytic subunit beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta) (Q8BTZ7)
Organism: Mus musculus (Mouse)
Function: Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Y5P6}.
Interaction partners:
- Mannose-1-phosphate guanylyltransferase regulatory subunit alpha
- Phosphomannomutase 2
- Dolichol-phosphate mannosyltransferase subunit 1
- Phosphomannomutase 1
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Dolichol-phosphate mannosyltransferase subunit 3
- GDP-mannose 4,6 dehydratase
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- Protein O-mannosyl-transferase 2
- Ribitol 5-phosphate transferase FKRP
Sequence:
MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQMLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLKPTSIEKEIFPVMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKHPERLYSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDAHIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM
Protein: Endoribonuclease LACTB2 (Beta-lactamase-like protein 2) (EC 3.1.27.-) (Q99KR3)
Organism: Mus musculus (Mouse)
Function: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q53H82}.
Interaction partners:
- Endoribonuclease YbeY
Sequence:
MAAALQRIEQLSSRVVRVLGCNPGPMTLQGTNTYLVGTGSRRILIDTGEPSVPEYISCLKQALVEFDTAIQEILVTHWHSDHSGGIVDICKNINNDTTYCIKKLRRNPQREEIIGNGEQQFIYIENGDVVKTEGATLRVLYTPGHTDDHMALLLEEENAIFSGDCILGEGTTIFEDLYDYMNSLNNLLKIKANIIYPGHGPVIHNAEAKILEYISHRNNREEQIISLFRDNFEKSFTVTELRTMIYKDVPENLHKMAEHNLLLHLRKLEKDGKIFYTTTPVKKWKAVL
Protein: Two-component response regulator ARR2 (Receiver-like protein 5) (Q9ZWJ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Involved in the expression of nuclear genes for components of mitochondrial complex I. Promotes cytokinin-mediated leaf longevity. Involved in the ethylene signaling pathway in an ETR1-dependent manner and in the cytokinin signaling pathway.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:11135105, ECO:0000269|PubMed:11574878, ECO:0000269|PubMed:15282545}.
Interaction partners:
- Transcription factor TGA3
- Histidine-containing phosphotransfer protein 3
- Histidine-containing phosphotransfer protein 2
- Histidine-containing phosphotransfer protein 5
- Histidine-containing phosphotransfer protein 1
- Histidine kinase 3
- Histidine-containing phosphotransfer protein 4
- Pseudo histidine-containing phosphotransfer protein 6
- Histidine kinase 2
- Histidine kinase 4
Sequence:
MVNPGHGRGPDSGTAAGGSNSDPFPANLRVLVVDDDPTCLMILERMLMTCLYRVTKCNRAESALSLLRKNKNGFDIVISDVHMPDMDGFKLLEHVGLEMDLPVIMMSADDSKSVVLKGVTHGAVDYLIKPVRIEALKNIWQHVVRKKRNEWNVSEHSGGSIEDTGGDRDRQQQHREDADNNSSSVNEGNGRSSRKRKEEEVDDQGDDKEDSSSLKKPRVVWSVELHQQFVAAVNQLGVDKAVPKKILEMMNVPGLTRENVASHLQKYRIYLRRLGGVSQHQGNMNHSFMTGQDQSFGPLSSLNGFDLQSLAVTGQLPPQSLAQLQAAGLGRPTLAKPGMSVSPLVDQRSIFNFENPKIRFGDGHGQTMNNGNLLHGVPTGSHMRLRPGQNVQSSGMMLPVADQLPRGGPSMLPSLGQQPILSSSVSRRSDLTGALAVRNSIPETNSRVLPTTHSVFNNFPADLPRSSFPLASAPGISVPVSVSYQEEVNSSDAKGGSSAATAGFGNPSYDIFNDFPQHQQHNKNISNKLNDWDLRNMGLVFSSNQDAATATATAAFSTSEAYSSSSTQRKRRETDATVVGEHGQNLQSPSRNLYHLNHVFMDGGSVRVKSERVAETVTCPPANTLFHEQYNQEDLMSAFLKQEGIPSVDNEFEFDGYSIDNIQV
Protein: Kelch domain-containing protein 4 (Q8TBB5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPPPSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRRGRKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDSLEEAGSPAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEMDPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAED
Protein: Transcriptional regulatory protein UhpA (P0AGA6)
Organism: Escherichia coli (strain K12)
Function: Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Signal transduction histidine-protein kinase/phosphatase UhpB
- Membrane sensor protein UhpC
- Hexose-6-phosphate:phosphate antiporter
- Putative HTH-type transcriptional regulator YhjB
- CsgBAC operon transcriptional regulatory protein
- Acetolactate synthase isozyme 1 small subunit
- Glycerol-3-phosphate transporter
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase
- Nitrate/nitrite sensor protein NarX
- Nitrate/nitrite sensor protein NarQ
Sequence:
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW
Protein: Photosystem II reaction center protein L (PSII-L) (Q71U33)
Organism: Oryza sativa (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01317}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01317}.
Interaction partners:
Sequence:
MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
Protein: Nuclear cap binding complex subunit CBP30 (Q387Z0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- C3H1-type domain-containing protein
- Nuclear cap binding complex subunit CBP110
- Nuclear cap-binding protein subunit 2
Sequence:
MRRGSGFVHLNTPAAISYSPGQQVSLSDLRQKRRREECVVLPPIMTVWRSAFSQYTKMWGLTKFAGDIEAEREGEGPILPPIREETVVKSTTHSFKGKSTTVAAAVATPPGEKGIEIVSHHKLCGKQRFVYPDHDGVLSSGIVPKVVISKEEEEEMEANKKYYISPQEMTEEERNAFEELDAMWKSYARGRSEQGARHRAFAGTVTPGDAMTEVEEETGNNRGNARRRLESHTPRQHPQESAAEGNSVAHNTEEALDDALRLIDELLEFN
Protein: Myocyte enhancer factor 2aa (Q1LXH6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- NK2 homeobox 5.
- Myogenin.
- Myoblast determination protein 1 homolog
- Myogenic factor 6
- Myogenic factor.
- Mitogen-activated protein kinase 14B
- Mitogen-activated protein kinase 14A
- mitogen-activated protein kinase
- Mitogen-activated protein kinase 12
Sequence:
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEKLRNKGHNDCPSPDPDDCFGHSPLMDDRFGKLNEESDLMYKRCGPTALPPQNFSMHVAVPVTNPNAMSYNPGASLSSQSLSAAASLSDGAMLSPPQGSMHRSVVPPQRPPSTGSTGNGFVNPRGSPGLLGTPSGNGLGKVMPAKSPPPPGGNMGIGSRKPDLRVVIPPSSKGMMPPLNTQRISSSQSTQPLATPVVSVTTPSLAPQGLVYSGMPTAYNSEYSLSSAELSSLQGFGSPGLSIGSVSAWQQHQLGQAALSSLVGGGHLPQGSNLSINTSQNVNIKSEPISPPRERVTPSGFPPQQQQPPSGRPDMGRSPVDSLSSSCSSYDGSDREDHRPDFHSPLGLGRPPAGGADERESPSVKRMRMDTWVT
Protein: Uncharacterized protein (Q8IK62)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MSRIDTRNNSYRRQNSKAVNEYLYEIIRARNKQAQRKKYLKIFLCISLCILFFLIGYAFIMYNGSVDGRKSLYPKKCSRKSRSLSELVLANYPSSNYAFSNYASANYSSSNYPSSKMDDLKRHENNCSSSNKAVDEEGICKDTFGNALDVPKYENDSFHRDYHKSMFDIKNIKLEEISLPLSKLELSHIISRLNKDVPKEYLMNLWLQAFAVSNDLVDIVNLLNEYIQYYKNQVDKCIELTSNGNYSCWKNCNVELAQALLFEHIEYKTKFYKVLITRHM
Protein: Guanylate cyclase (EC 4.6.1.2) (C7LAF5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MFAHPCPAPAGNYHSGLLHPLLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLPRNSLTRSSSLESPKKLRFAAGSLLEHHRYHSDEALLEVDSYTGLRRSSGGSTQSRYEETTLSLTLSCQSIEIVGGQHNKRRPSSYPTANTPLLMNHVEV
Protein: Collagen alpha-1(X) chain (P08125)
Organism: Gallus gallus (Chicken)
Function: Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Runt-related transcription factor
- Indian hedgehog protein
- Transcription factor SOX-9
- ZnMc domain-containing protein.
- Parathyroid hormone-related protein
- A disintegrin and metalloproteinase with thrombospondin motifs 5
Sequence:
MHLQISLLLLFCLNIVHGSDGYFSERYQKQSSIKGPPHFLPFNVKSQGVQMRGEQGPPGPPGPIGPRGQPGPAGKPGFGSPGPQGPPGPLGPPGFSTVGKLGMPGLPGKPGERGLNGEKGEAGPVGLPGARGPQGPPGIPGPAGLSVLGKPGPQGPPGAQGPRGPPGEKGEPGVPGINGQKGEMGFGVPGRPGNRGLPGPQGPQGLPGSAGIGKPGENGLPGQPGMKGDRGLPGARGEAGIPGPQGPPGEPGEVGIGKPGPMGPPGPAGIPGAKGLPGPAGLPGSPGLPGFGKPGLPGMKGHRGPEGPPGFPGPKGDQGPAGVPGELGPAGPQGNMGPQGLKGLPGENGLPGPKGDMGPVGPAGFPGAKGERGLPGLDGKPGYPGEQGLPGPKGHPGLPGQKGDTGHAGHPGLPGPVGPQGVKGVPGINGEPGPRGPSGIPGVRGPIGPPGMPGAPGAKGEAGAPGLPGPAGIVTKGLRGPMGPLGPPGPKGNSGEPGLPGPPGPPGPPGQSTIPEGYVKGESRELSGMSFMKAGANQALTGMPVSAFTVILSKAYPGATVPIKFDKILYNRQQHYDPRTGIFTCRIPGLYYFSYHVHAKGTNVWVALYKNGSPVMYTYDEYQKGYLDQASGSAVIDLMENDQVWLQLPNSESNGLYSSEYVHSSFSGFLFAQI
Protein: C-terminal-binding protein 2a (C-terminal-binding protein 2a isoform X7) (CtBP2 protein) (Q9DEG6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MALIDKHKVKRQRLDRICEGIRPQIMNGPMHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRIIIRIGSGYDNIDIKAAGEMGIAVCNIPSAAVEETADSTLCHILNLYRRNTWLYQAMREGTRVQSVEQIREVASGAARIRGETLGLIGFGRSGQAVAVRAKAFGFNVIFYDPYLQDGLERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFTQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPDSLRNCVNKEFFVTTAPWGVMEQQVHPELNGGAYRFPPGAVGVSPGGMGGQIEGMMPGGLPSAHPLPPGTQPSLAPSPTQLLKHNDHREHLAKS
Protein: Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) (MRP-S17) (S17mt) (Q9Y2R5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25838379}.
Interaction partners:
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein mS27
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein mS25
- Small ribosomal subunit protein uS5m
Sequence:
MSVVRSSVHARWIVGKVIGTKMQKTAKVRVTRLVLDPYLLKYFNKRKTYFAHDALQQCTVGDIVLLRALPVPRAKHVKHELAEIVFKVGKVIDPVTGKPCAGTTYLESPLSSETTQLSKNLEELNISSAQ
Protein: ATP-dependent RNA helicase DBP1 (EC 3.6.4.13) (DEAD box protein 1) (Helicase CA1) (P24784)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Redundant to DED1, may be required in conditions in which DED1 expression is decreased.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- ATP-dependent RNA helicase DED1
- Pre-mRNA-splicing factor SNU114
- ATP synthase subunit beta, mitochondrial
- Pre-mRNA-splicing factor 6
- ATP synthase subunit gamma, mitochondrial
- Pre-mRNA-splicing factor CEF1
- ATP synthase subunit alpha
- ATP synthase subunit delta, mitochondrial
- ATP synthase subunit 5, mitochondrial
- ATP synthase subunit d
Sequence:
MADLPQKVSNLSINNKENGGGGGKSSYVPPHLRSRGKPSFERSTPKQEDKVTGGDFFRRAGRQTGNNGGFFGFSKERNGGTSANYNRGGSSNYKSSGNRWVNGKHIPGPKNAKLEAELFGVHDDPDYHSSGIKFDNYDNIPVDASGKDVPEPILDFSSPPLDELLMENIKLASFTKPTPVQKYSIPIVTKGRDLMACAQTGSGKTGGFLFPLFTELFRSGPSPVPEKAQSFYSRKGYPSALVLAPTRELATQIFEEARKFTYRSWVRPCVVYGGAPIGNQMREVDRGCDLLVATPGRLNDLLERGKVSLANIKYLVLDEADRMLDMGFEPQIRHIVEECDMPSVENRQTLMFSATFPVDIQHLARDFLDNYIFLSVGRVGSTSENITQRILYVDDMDKKSALLDLLSAEHKGLTLIFVETKRMADQLTDFLIMQNFKATAIHGDRTQAERERALSAFKANVADILVATAVAARGLDIPNVTHVINYDLPSDIDDYVHRIGRTGRAGNTGVATSFFNSNNQNIVKGLMEILNEANQEVPTFLSDLSRQNSRGGRTRGGGGFFNSRNNGSRDYRKHGGNGSFGSTRPRNTGTSNWGSIGGGFRNDNEKNGYGNSNASWW
Protein: Dipeptidyl aminopeptidase BII (DAP BII) (EC 3.4.14.-) (V5YM14)
Organism: Pseudoxanthomonas mexicana
Function: Exopeptidase that catalyzes the removal of dipeptide units (NH2-P2-P1-) from the free amino termini of oligopeptides and small proteins. Peptide digestion is sequential and substrate recognition is non-specific, with the exception that Pro is not suitable as a P1 residue. Removes many residues of bioactive oligopeptides such as angiotensin I and neuromedin N and cleaves also oxidized insulin B chain. Able to hydrolyze an X-Pro bond, an imido bond. No endopeptidase activity. May play a physiological role in feeding.
Interaction partners:
Sequence:
MRPNLLAAAIAVPLSLLAAQIAQAGEGMWVPQQLPEIAGPLKKAGLKLSPQQISDLTGDPMGAVVALGGCTASFVSPNGLVVTNHHCAYGAIQLNSTAENNLIKNGFNAPTTADEVSAGPNARVFVLDEITDVTKDAKAAIAAAGDDALARTKALEAFEKKLIADCEAEAGFRCRLYSFSGGNTYRLFKNLEIKDVRLAYAPPGSVGKFGGDIDNWMWPRHTGDFAFYRAYVGKDGKPAAFSKDNVPYQPKHWLKFADQPLGAGDFVMVAGYPGSTNRYALAAEFDNTAQWTYPTIARHYKNQIAMVEAAGKQNADIQVKYAATMAGWNNTSKNYDGQLEGFKRIDAAGQKLREEAAVLGWLKGQGAKGQPALDAHAKLLDLLEQSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAERESGYQERDLPAIEGGLKQLERRYVAAMDRQLQEYWLNEYIKLPADQRVAAVDAWLGGNDAAAVKRALDRLAGTKLGSTEERLKWFAADRKAFEASNDPAIQYAVAVMPTLLKLEQERKTRAGENLAARPVYLQALADYKKSQGEFVYPDANLSLRITFGNVMGYAPKDGMEYTPFTTLEGVVAKETGQDPFDSPKALLDAVAAKRYGGLEDKRIGSVPVNYLSDLDITGGNSGSPVLDAHGKLVGLAFDGNWESVSSNWVFDPKMTRMIAVDGRYLRWIMQEVYPAPQLLKEMNVGK
Protein: Mitochondrial transcription termination factor 4 (cDNA FLJ54914, highly similar to Homo sapiens MTERF domain containing 2 (MTERFD2), mRNA) (B4DKD5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAFGRQVLDWHRLIPLTWACMARQTPHLGEQRRTTASLLRKLTTASNGGVIEELSCVRSNNYVQEPECRRNLVQCLLEKQGTPVVQGSLELERVMSSLLDMGFSNAHINELLSVRRGASLQQLLDIISEFILLGLNPEPVCVVLKKSPQLLKLPIMQMRKRSSYLQKLGLGEGKLKRVLYCCPEIFTMRQQDINDTVRLLKEKCLFTVQQVTKILHSCPSVLREDLGQLEYKFQVRMTDSVISVVSGENDW
Protein: Uncharacterized protein D2096.6 (Q19005)
Organism: Caenorhabditis elegans
Interaction partners:
- Prion-like-
- Neuronal Membrane GlycoProtein
- Uncharacterized protein
- Uncharacterized protein T25E4.1
- MYOsin heavy chain structural genes
- TLC domain-containing protein
Sequence:
MFSKLFTTSCLVAIALTTAQEEVSGKVSSTKRRQYVAAQQPAVPVVAPVGQCPGGPSLPIECDPKRPWPQCPPQSYCYATNSVDIGPYFCCPVWSTYGAAWRPATPFYNYVPPVPANWPDVAKMTANWPAAAVSVPVKARKPTKSDDEEEEVGKMGGISSSINSWVQRQKL