wanglab/gogpt-training-data huggingface dataset:
Protein: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) (P9WN83)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Phosphoglycerate kinase
- Triosephosphate isomerase
- Fructose-bisphosphate aldolase
- Enolase
- Glucose-6-phosphate isomerase
- Transketolase
- Glucose-6-phosphate 1-dehydrogenase 2
- Transaldolase
- Glucose-6-phosphate 1-dehydrogenase 1
- Pyruvate kinase
Sequence:
MTVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNSTLAHLLKFDSILGRLPCDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVVVESTGLFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQNIISNASCTTNCLAPLAKVLDDEFGIVKGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVMPQLKGKLDGYALRVPIPTGSVTDLTVDLSTRASVDEINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIFDSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTLVGKSL
Protein: Ribosomal RNA small subunit methyltransferase I (EC 2.1.1.198) (16S rRNA 2'-O-ribose C1402 methyltransferase) (rRNA (cytidine-2'-O-)-methyltransferase RsmI) (P9WGW7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01877}.
Interaction partners:
- Ribosomal RNA small subunit methyltransferase H
- tRNA
- Ribosomal RNA small subunit methyltransferase E
- Polyprenol-phosphate-mannose--protein mannosyltransferase
- Ribosomal RNA small subunit methyltransferase G
- Probable dual-specificity RNA methyltransferase RlmN
Sequence:
MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKLAKALDIRIGGRVVSLFDRVEALRVTALLDAINNGATVLVVSDAGTPVISDPGYRLVAACIDAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWLAELAEERRTCVFFESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVVRGSLDELAIWAAGGVLGEITVVVAGAAPHAELSSLIAQVEEFVAAGIRVKDACSEVAAAHPGVRTRQLYDAVLQSRRETGGPAQP
Protein: Golgi/lysosome glycoprotein 1 (Q581Z5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRRSFFVALLLQLSHASVRALSLFPTCSENEYTGGGLPGKEWVVQRFDKPGRNLTIHCLAYEVKPVDTTNAKDMGPGPCQIDHQTEFSFRLFVRATYKDSKSGEQVTEEYDVKDMAGGSLSDVAIRLAHKSDLSLVFANTAANHECGLEARVSFRFTHDAKVAAVSDVPVLVGVQPRIVHAKNSVPTRFIFRSSDSTKGGVSEREEFFLISAKEECSTSTGSNSYLMSHPSSPPLFDEDFTGANTSTFAARDVFIDTARAYRICSRKANTEDVTEVGVVRSFEVNPSYYQVVGGQNADGKVYVMKRTTIKFYGSDLDTRPRRNQAKFVSDTEDCDASAAGGVPETLALEPEDRFGPKATSVLWSWVLKRGGAYKVCFKRTGMPWVEVPSIDIVNSAADITNADGNITYRQPVDPVTKELCPMAPPNTPENRWSMYNSIMLTLKSKTLPSNYLQTLSKALCVPRTAMALSRVTHGKDGRVRLFISIFCEELGEDRTCDTVERQNYIISASKQGSEALAAAGIESAEGSRDMFALGDDPNPRMGWGRVLSIFAICGTVVAVACLVVYGVLKYRENRQYFVNFGVEDEDVDDMYISNIPTAGAAVNSAGTKGSVIEVED
Protein: Aftiphilin (B8ZZI9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XIRREQCKTEEKLDLLTSKCAHLCMDSVKTSDDEVGSPKEESRKFTNFQSPNIDPTEENDLDDSLSVKNGDSSNDFVTCNDINEDDFGDFGDFGSASGSTPPFVTGTQDSMSDATFEESSEHFPHFSEPGDDFGEFGDINAVSCQEETILTKSDLKQTSDNLSEECQLARKSSGTGTEPVAKLKNGQEGEIGHFDSVPNIQDDCNGFQDSDDFADFSSAGPSQVVDWNAFEDEQKDSCSWAAFGDQQATESHHRKEAWQSHRTDENIDTPGTPKTHSVPSATSKGAVASGHLQESATSVQTALLNRLERIFEACFPSILVPDAEEEVTSLKHLLETSTLPIKTREALPESGELLDVWTELQDIHDAHGLRYQWGGSHSNKKLLSSLGIDTRNILFTGNKKQPVIVPMYAAGLGMLEPTKEPLKPLSAAEKIASIGQTATMSPDMNTCTSDQFQESLPPVQFDWSSSGLTNPLDASGGSTLLNLDFFGPVDDSSSSSSTTIPGVDPELYELTTSKLEISTSSLKVTDAFARLMSTVEKTSTSTSRKPKREEHLSEEAIKVIAGLPDLTFMHAKVLMFPATLTPSTSSQEKADG
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Q4JL29)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCLTCSSVLCGRYVNGHAKKHYEDAQIPLLNHKRSEKQEKAQHTVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHLQSLENSAFTADRHRKRKLLENSSLNSKLLKVNGSTAAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDSNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYRQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSANNKCCINGASTVVTTIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKALCLHLKRFHWTAYLRNKVDTYVQFPLRGLDMKCYLLEPENSGPDSCLYDLAAVFVHHGSGVGSGHYTAYAVHEGRWFHFNDSTVTVTDEETVGKAKAYILFYVERQARAGADKL
Protein: Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-) (Q9Y295)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions.
Subcellular location: Nucleus {ECO:0000269|PubMed:29915238}. Cytoplasm {ECO:0000269|PubMed:15676025, ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:29915238}. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes.
Interaction partners:
- Zinc finger CCCH domain-containing protein 15
- RWD domain-containing protein 1
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein uS7m
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL10
- 26S proteasome regulatory subunit 7
- DNA polymerase epsilon subunit 2
- Translin
- Citrate synthase, mitochondrial
Sequence:
MSSTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK
Protein: DNA polymerase I (POL I) (EC 2.7.7.7) (P9WNU5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
Interaction partners:
- Beta sliding clamp
- Protein RecA
- Putative lipoprotein LppK
- Calcineurin-like phosphoesterase domain-containing protein
- ERCC4 domain-containing protein
- DNA topoisomerase 1
- ATP-dependent helicase DinG
- Uncharacterized protein Rv1278
- Multifunctional non-homologous end joining DNA repair protein LigD
- Replicative DNA helicase DnaB
Sequence:
MVTTASAPSEDRAKPTLMLLDGNSLAFRAFYALPAENFKTRGGLTTNAVYGFTAMLINLLRDEAPTHIAAAFDVSRQTFRLQRYPEYKANRSSTPDEFAGQIDITKEVLGALGITVLSEPGFEADDLIATLATQAENEGYRVLVVTGDRDALQLVSDDVTVLYPRKGVSELTRFTPEAVVEKYGLTPRQYPDFAALRGDPSDNLPGIPGVGEKTAAKWIAEYGSLRSLVDNVDAVRGKVGDALRANLASVVRNRELTDLVRDVPLAQTPDTLRLQPWDRDHIHRLFDDLEFRVLRDRLFDTLAAAGGPEVDEGFDVRGGALAPGTVRQWLAEHAGDGRRAGLTVVGTHLPHGGDATAMAVAAADGEGAYLDTATLTPDDDAALAAWLADPAKPKALHEAKAAVHDLAGRGWTLEGVTSDTALAAYLVRPGQRSFTLDDLSLRYLRRELRAETPQQQQLSLLDDDDTDAETIQTTILRARAVIDLADALDAELARIDSTALLGEMELPVQRVLAKMESAGIAVDLPMLTELQSQFGDQIRDAAEAAYGVIGKQINLGSPKQLQVVLFDELGMPKTKRTKTGYTTDADALQSLFDKTGHPFLQHLLAHRDVTRLKVTVDGLLQAVAADGRIHTTFNQTIAATGRLSSTEPNLQNIPIRTDAGRRIRDAFVVGDGYAELMTADYSQIEMRIMAHLSGDEGLIEAFNTGEDLHSFVASRAFGVPIDEVTGELRRRVKAMSYGLAYGLSAYGLSQQLKISTEEANEQMDAYFARFGGVRDYLRAVVERARKDGYTSTVLGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVAMIQVDKALNEAQLASRMLLQVHDELLFEIAPGERERVEALVRDKMGGAYPLDVPLEVSVGYGRSWDAAAH
Protein: Myb-like DNA-binding protein (Q59T43)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MFNRPEHYPPQHINQPHQDPNLNHQPFNYSHQYNGLPPIGMMMQSNTHYQPQAQPQVPQPTAIPHSQLPVHLQQQQQQQPPLVQQHHYIHQQPVFHQSNHMVTHDHKPSTSSSHKRGPWSREEDEKLLELIKIHGASNWVKISSSLETRTAKQCRERYHQNLKPSLNRSPITPEEGAKIERLVAIHGKKWAEISRHLEGRSDNAIKNWWNGGANRRRRASLATTTSSINGNNSIAEELQRKSPTPETATINSEAEMTNKQDSTYSKSILPQPQPQPQPSQSITNYPPASAPVQPQPFQHAQPQRLPSFHQLPQIAFKTSMFGKDNEKSTLPSLSKSLHPSSLSSSTPPPPENHQAAAGSSPLKSISHRSASFDINSNILPPISQSNKRRLIDDQFGRRHSSVSSTIFHNQKNVSHPNLLLVHSARTSVSGPSGSNYGTGSPSYNGSPLSMSTAASRNNSITHFELINNSTIPSRRSSTFNSDLFPNPLAKENNNGNDNHKRRESQNSSFNSPMLTPSTRFSVSSMTSVHNSTIHNYNSSSVTSPTTSFKNAYSASSTSINLPVEEEEPETGADKQKINEPSKDEVTAEQNGDEKVGKKRMAVSSLLD
Protein: Phosphatidylinositol 4-phosphate 5-kinase MSS4 (EC 2.7.1.68) (1-phosphatidylinositol 4-phosphate kinase) (Diphosphoinositide kinase) (PIP5K) (P38994)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate. Acts downstream of STT4, but in a pathway that does not involve PKC1. May be involved in the organization of the actin cytoskeleton.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22562153}; Peripheral membrane protein {ECO:0000250|UniProtKB:O13853}. Note=Forms dynamic oligomeric patches at the cell membrane (PubMed:22562153). Localization to the cell membrane is dependent on its ability to bind substrate (PubMed:22562153). {ECO:0000269|PubMed:22562153}.
Interaction partners:
- Phosphatidylinositol 4-kinase STT4
- Phosphatidylinositol 4-kinase PIK1
- Protein transport protein SSS1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 4-kinase LSB6
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51
- Polyphosphatidylinositol phosphatase INP52
- Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1
- Polyphosphatidylinositol phosphatase INP53
Sequence:
MSVLRSQPPSVVPLHLTTSTSRKTEQEPSLLHSAIIERHQDRSVPNSNSNPDSNHRIKKDRNNHTSYHSSSNSESNMESPRLSDGESSTPTSIEELNPTINNSRLVKRNYSISIDPLHDNSNNNTDDDHPNTITSPRPNSTSNKEMQKYSFPEGKESKKITTPSLNSNNCLDLDNSSLVHTDSYIQDLNDDHILLNKRVSRRSSRISAVTATSTTIKQRRNTQDSNLPNIPFHASKHSQILPMDDSDVIKLANGDTSMKPNSATKISHSMTSLPLHPLPQPSQKSKQYHMISKSTTSLPPENDHYYQHSRGTNHNHAANAAAVNNNTTTTTAATGLKRSESATAEIKKMRQSLLHKREMKRKRKTFLVDDDRVLIGNKVSEGHVNFIIAYNMLTGIRVAVSRCSGIMKPLTPADFRFTKKLAFDYHGNELTPSSQYAFKFKDYCPEVFRELRALFGLDPADYLVSLTSKYILSELNSPGKSGSFFYYSRDYKYIIKTIHHSEHIHLRKHIQEYYNHVRDNPNTLICQFYGLHRVKMPISFQNKIKHRKIYFLVMNNLFPPHLDIHITYDLKGSTWGRFTNLDKERLAKDRSYRPVMKDLNWLEEGQKIKFGPLKKKTFLTQLKKDVELLAKLNTMDYSLLIGIHDINKAKEDDLQLADTASIEEQPQTQGPIRTGTGTVVRHFFREFEGGIRASDQFNNDVDLIYYVGIIDFLTNYSVMKKLETFWRSLRHDTKLVSAIPPRDYANRFYEFIEDSVDPLPQKKTQSSYRDDPNQKNYKD
Protein: NEDD8-activating enzyme E1 regulatory subunit AXR1 (Auxin-resistance protein AXR1) (Protein AUXIN-RESISTANT 1) (P42744)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulatory subunit of the dimeric ECR1-AXR1 E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1. Plays an important role in auxin response. Regulates the chromosomal localization of meiotic recombination by crossovers (COs) and subsequent synapsis, probably through the activation of a CRL4 complex. Required for E3-mediated protein degradation in response to auxin, jasmonic acid and cold stress. Required for the COP1-COP10-CSN-mediated repression of photomorphogenesis in the dark. May function redundantly with AXL1 in the RUB conjugating pathway. Seems not to be functionally equivalent to AXL1 in vivo.
Subcellular location: Nucleus {ECO:0000269|PubMed:9624055}.
Interaction partners:
- NEDD8-activating enzyme E1 catalytic subunit
- NEDD8-conjugating enzyme Ubc12
- Probable NEDD8-conjugating enzyme Ubc12-like
- Ubiquitin-NEDD8-like protein RUB1
- F12F1.16 protein
- NEDD8-like protein RUB3
- Auxin-responsive protein IAA7
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Auxin transporter protein 1
- RING-box protein 1a
Sequence:
MQAVKRSRRHVEEEPTMVEPKTKYDRQLRIWGEVGQAALEEASICLLNCGPTGSEALKNLVLGGVGSITVVDGSKVQFGDLGNNFMVDAKSVGQSKAKSVCAFLQELNDSVNAKFIEENPDTLITTNPSFFSQFTLVIATQLVEDSMLKLDRICRDANVKLVLVRSYGLAGFVRISVKEHPIIDSKPDHFLDDLRLNNPWPELKSFVETIDLNVSEPAAAHKHIPYVVILVKMAEEWAQSHSGNLPSTREEKKEFKDLVKSKMVSTDEDNYKEAIEAAFKVFAPRGISSEVQKLINDSCAEVNSNSSAFWVMVAALKEFVLNEGGGEAPLEGSIPDMTSSTEHYINLQKIYLAKAEADFLVIEERVKNILKKIGRDPSSIPKPTIKSFCKNARKLKLCRYRMVEDEFRNPSVTEIQKYLADEDYSGAMGFYILLRAADRFAANYNKFPGQFDGGMDEDISRLKTTALSLLTDLGCNGSVLPDDLIHEMCRFGASEIHVVSAFVGGIASQEVIKLVTKQFVPMLGTYIFNGIDHKSQLLKL
Protein: Receptor-like protein 4 (AtRLP4) (F4HWL3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- At3g52790
- Jacalin-related lectin 19
- Pectinesterase inhibitor 5
Sequence:
MMLRFILASLLLSSFSLYSSLARPAPYALRISCGARKNVRTPPTYALWFKDIAYTGGVPANATTPTYITPPLKTLRYFPISEGPNNCYNIVRVPKGHYSVRIFFGLVDQPSFDKEPLFDISIEGTQISSLKSGWSSQDDQVFAEALIFLLGGTATICFHSTGHGDPAILSIEILQVDDKAYSFGEGWGQGVILRTATRLTCGTGKSRFDEDYRGDHWGGDRFWNRMRSFGKSADSPRSTEETIKKASVSPNFYPEGLYQSALVSTDDQPDLTYSLDVEPNRNYSVWLHFAEIDNTITAEGKRVFDVVINGDTFFEDVDIIKMSGGRYAALVLNATVTVSGRTLTVVLQPKAGGHAIINAIEVFEIITAEFKTLRDEVSALQKMKKALGLPSRFGWNGDPCVPPQHPWSGANCQLDKNTSRWFIDGLDLDNQGLKGFLPNDISKLKHLQSINLSENNIRGGIPASLGSVTSLEVLDLSYNSFNGSIPETLGELTSLRILNLNGNSLSGKVPAAVGGRLLHRASFNFTDNAGLCGIPGLPACGPHLSSGAKIGIAFGVSLAFLLIVACAMIWWKRRQNILRAQQIAARGAPYAKKRTHVSHDIQMSRHGHNNHGQARTAVENGPSLLS
Protein: Uncharacterized protein (Q57YS4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPTPQQSEGKDLHRRFAEAAKGVTELYRNATLSYNAGYRDALLLVERYALIAAQSGEATPHGALRRDDRTSDGGTDRNSHLSDQSISNGDSISISSSQDSAIPASRTSFAQWGTQSPQLLNIKQLLWFIQNIVKSHDALTGAPRTLKRRRRRSCSSAGVRGCAVGNDNEDNTSSGEGGGSGGGFGGLPIPRFRSPQHRAENWNELLLLGEGRATPHTDADGINSEGEL
Protein: GH27795p (Q95R30)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTTESMSAPPRTNWAVSRPPTRLSSTPPTLRADRASCLPLLCRKEEEAESQPMPRPRARRRRRRMSPKVGDGGYERRSRMPDPSPKQMLYFTVNLSNRYVAEGSKVKLQAVIGGPQPMIKWLKDDQNVTYGPNIRNMNRDSLAVLEFTNAKVEDSGTYSIVAQNESCKITTSAMLHVYETKVNTDVQPVFIRSLKETYHLNTNELILETAVRGQPTPAVQWFKDSIEIQSGGRFQIIEHQDGTCELIIDRPDNKDSGKYVVKAESRAGKMEISHYVLFEGQSHHIAENIHGVFHADKSLLRPKEVEKPVEKKPAPAAEPESEAEDGKAKRRAKKEEDDGASSAYATDYASDTASLSSKRREKNIAIHFSTSMRDRVVAEGSKVKISCFLEAKEPQVKWFKDGEQIQNSPKIRGRYSEGLCLLEVMSATAEDNGEYKCWGRDETGEASTSCRLEVYENPGTGDVPPTFTRNIKDTMHGKINELQLDVHVRGLPTPAVTWVKDGVKIENSDKYQQVDHDDGTCELVHQSPEGFG
Protein: FMRFamide-like neuropeptides 2 [Cleaved into: SPREPIRF-amide; LRGEPIRF-amide] (G5EFN6)
Organism: Caenorhabditis elegans
Function: FMRFamide-like neuropeptides. Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide pdf-1. Involved in neural modulation of systemic mitochondrial unfolded protein response.
Interaction partners:
- FMRFamide peptide receptor frpr-18
- FMRFamide-like neuropeptides 5
- FMRFamide-like neuropeptide 21
- FMRF-Like Peptide
- FMRF-Like Peptide
- FMRF-Like Peptide
- FMRFamide-like neuropeptides 11
- FMRFamide-like neuropeptides 14
- FMRFamide-like neuropeptides 13
- Neuropeptide-like protein 1
Sequence:
MQVSGILSALFLVLLAVIVSPFQFVQPKRILPIPTSRDQLLRGQLAYLKGTTVAQPAVNDNTLGIFEASAMAKRLRGEPIRFGKRSPREPIRFGKRFNPLPDYDFQ
Protein: Rhomboid-like protein 18 (AtRBL18) (Q8RXQ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- F3N23.33 protein
- Mucin
- Rhomboid-like protein 17, chloroplastic
- Transmembrane protein
- RHOMBOID-like protein 13
- Rhomboid-like protein 19
- Rhomboid-like protein 16, chloroplastic
- RHOMBOID-like protein 10, chloroplastic
- Rhomboid-like protein 15
- Rhomboid-like protein 14, mitochondrial
Sequence:
MNGGPSGFNNAPVTKAFVIATALFTVFFGIRGGSSKLGLSYQDIFEKFRIWKLIISAFAFSSTTQLLSGLYLLYFFRVFERQIGSNKYSVFIFFSGFVSLILETILLSLTKDPTANLLTSGPYALVFASFVPFFLDIPVTKRFGVLGVHFSDKSFIYLAGVQLLLSSWKRSIFTGICGIIAGSLYRLNIFGIRKAKFPEFMASLFSRFSLPSLSSHSQPPRRTSPNLGRQAVRAYRAPMPSTTEPSEEAIATLVSMGFDQNAARQALVHARNDVNAATNILLEAHSH
Protein: ATP-dependent DNA helicase II subunit 2 (EC 3.6.4.12) (ATP-dependent DNA helicase II subunit Ku80) (Q6FN20)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}.
Interaction partners:
- ATP-dependent DNA helicase II subunit 1
- DNA ligase 4
- Double-strand break repair protein
- DNA ligase
- Candida glabrata strain CBS138 chromosome I complete sequence
- Telomerase reverse transcriptase
- Serine/threonine-protein kinase TEL1
- DNA repair and recombination protein RAD52
- Serine/threonine-protein kinase TOR
- Serine/threonine-protein kinase TOR
Sequence:
MSEATSVLIDVDVEPLIIAKVTAYLEYMLLDKARRGRKTDYVSAYLVNHTETQNSQDVPHVVRLCDFLAPTTEGAIALLRQLALVRREYRGDNILQALLLASIDGRDYFGKRKVAKQLMIFTDKVSELDLSAEELQTLHEELDSRIILVDCSTHPHQNAQGSQWDALVRTVKGSMSFHIDELLLRITQTVPKVVKPVTVFSGQLRLGASLENIVDLEPHRRDEAAAADNPKKRQFPFGFRTEANYADDHCLCIGVQGYPATKKTGSLQKKTVVKDASKPGFVPVKSVIDYELRDNEVEGEGKGKGEGDAPPITVARESITKAYRYGTDYVVLPSSLEDQLVYQTYAGLDIRGFMNMSDMHRHFLTSESVFVVSSSSSADQITFSALIDAMIQIDKIAIGRYVPKNNSDVQMCMLYPMILEKENGTHVRTLILNRLPFTEDERIAIFPRLTREDDKKSEKDETIDQLMAGFVESRSMDDLPRVEEKKYYEFYEDSVRDTTLVLPMKSKDETRERDPLMVPAMGLHRQLQVMLEYLHQVVINKSEKFDPPELQDHLKAKITPHIVSDFPELEELVNLLELKKVEPKSKEFKPPAPAEPVPSLEELLKRGEAAREGES
Protein: HEAT repeat-containing protein 1 (Protein BAP28) (Q7SY48)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Required for cell survival in the CNS through its role in rRNA synthesis and processing.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9H583}.
Interaction partners:
- UTP18 small subunit processome component.
- Programmed cell death 11.
- Cirrhosis, autosomal recessive 1A
- U3 small nucleolar RNA-associated protein 15 homolog
- PWP2 small subunit processome component.
- Nucleolar protein 58
- UTP6 small subunit processome component.
- BMS1 ribosome biogenesis factor
- U3 small nucleolar RNA-interacting protein 2
- WD repeat domain 36
Sequence:
MTSLAHQLKRLALPQNDSSLLGRKEVVSVLFDPKDAASMDRSTFHALGCTGLEELMGIDAAFSEFQETLFSQGSLTLERSVQSKEVNKKLDKSISLFLTRLSPYFLLKPALKCIEWLLHRFHIHLYNQDSLIACVLPYHETKVFVRVIQLFKIEDPTHKWHWLHGIQKPGVPLARGTLLTHCYKDLGFMDFVCSMVTNSVKAYSELTRDGNCPQLRVIFSFYASTIVSALDAVEKITNSIIAKLLPFVQLGLKSNLSDYTAATYMIVCQMAVKVVMEAQLVDSLSVQLSRSLGRTPQLIREGLSCIIILLQNQKKGVIGQKTYGYLCAVPTLVSTLQSISTVHDISPLLSYLLPHLIHSVMTQNDEQQNEGLSDSTGLLQSVFQNLQLSSNLENTAAKLLLEEYVVCGNELPSDGISALNQRIQPTVRLFESRYPCALDMALENHVKNVSSDNEKNLLHQFISLTLSCGKYQILPESETSLMLSLNHPLPSVRNMAVDYLKEILNSEHNSFDEAFLKDALLERIKDDSPEVVLSALKALQHHMGLMDVEDTVSSLISLLHRIKPSADWCPVLKEAVRVLDDPRIIEGNPDLKAYISWELLPFLVMTRAAPECVELQMTSAITETTLISQHPLTQGWAKVLKAVLAKTSESDLLGVANEMLTTTLIKNLANMDHATKRNTLENVCDILSRQGSSVRDRAAFVVFSSALLQSLQSMTESQHLHTAQSVYKLLEPLLLQAYTIQPEQVSDQPADECLPVCVALGEFLQKISCGLSAEQEQGLLLLSLLRLFITTLKCPDSTFKGEPWWNPEKMETTTCCYLRLLCRLFDVVISGASQGPLAPCFRSLMQPLLQVHLNEPMVLFKFLSLSWGYNSNLGDQLDCRVSAILQTQALYVGKAFLSSQPVKTLNLLASDSSPVVPSLLVCVCSGVCEVRRAAIAVLQCLSGLVSSPYHPLVEKLLKSSEEIIADSSYLTQALSKFYEEAVSRKDKNKKLASVEQLLQCLQSPFCPSYTSKTLLRALQDVHGEPVLSVLLPAVERLLEQCAPDSCTFLPDEALLLQLLLSKFSEMSAPLLVKDPRCLEVFIRALHTSARPYPTIPSFQITALEQITKPFFTAIGDEKIQQKILSILFDLLVGNKSPACAQSINSVFKTIAVDCELVANELIPADKQRVTATVQQTRRSKMRKTQDTSGAVPEESVVSWPRVTLILELLQHKKKLKRAQYLVPALFNLLSRCLEPAAAEQENIEYTKQLILICLLNVCQKLSPEGGPISKDVLEEDKFNMELVVQCVRVSEMPQTHHHALLLLGALAGIFPEKVLHNIMPIFTFMGANIMRLDDTYSFQVINKTVQAVIPALIKAHEGGSSQSEGHMETVVAQIIHVFVDALPHVPEHRRLPILSQLMSTLGPSRFLWVLMLLLFKQHVTQTSAGATGAEKEAVVERDQDFWILVCCEFEVKEQLTSLIKILQYLMTLPQDREEAPEKKKPRGRSAVKKDETVSDLIFSVETHSGKDLRHFKFISISFMAQLLASDGFVGKVADCEDITESTLQALQQDLLVEVLRYIQAVARCVEDNADKPTAKFWRALLSKSYDTLDKVNALLPMDTFITVMRGLVGNQLASVRRKAMELLNNKLQQRTKWLKEQITALLELIGTLLSIVGRSHRQVTAQEEEELAINRQTALYSLKLLCRNFGSDHKEEFVPVLNKAVELVADKDEEKNVMGSALLCVAEVTSTLKALAIPQLHRLMPAVLDTLKERKDLLNNEIYLLSAVTALQRASETLPHFISPYLLDTILQVTRLTLLARRLTSCPQLSVRLASLSSTLATKLPPRVLIPTITKCYCSMVDAQQNRLSPLMNILKEHISHMDKDQLNNHQSELTSFFLSALDFRAQHCQGDLKKTAEIEGCVIDCLLVMIMKLSEVTFRPLFFKLFDWSKIDGASKDRLLTFYRLADRIADKLKGLFVLFAGQLVKPFSDLLHQLNISHTDKAFFDSEDESDDDSDEEADDNVTKSSLLLQYVLDCLHKIFLYDTQHFLSKERADALLCPLVDQLENMLGGEETYKSRITTHLVPCIAQFAVAMRDDSQWKVLNYQILLKTRHSSPKVRFSALVMLLELAGKLRENYMVLLPETIPFLAELMEDECEEVEHQVQKVIQEMETILGEPLQSYF
Protein: MPL proto-oncogene, thrombopoietin receptor (A0A1W2Q670)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MVTSCLLLAPPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTCFWDEEEAAPSWIYQLLYAYPGEKPRPCPLHSQSVPTFGTRYVCQFPALDEVRLFFPLHLWVKNVFLNQTLMQRVLFVDTVGLPAPPSVIKARGGSQPGELQIHWEAPAPEISNFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLRMPNPVRVLDQHPCVHPTASQQHGPMRTSPAGEAPSLAVKGGSCLISGLHAGQSYWLQLRSQPDGVSLRGSWGPWSLPVTVDLPGDAVAIGLQCFTVDLKKVICQWQQQDHSSSRGFFRHSRTRCCPTDRDPTWEKCEEEEEEEEEEKEEGELDPGSRPALFSRCHFKSRNDSVIHILVEVTTAQGAIHSYLGSPFWIRQAVLLPTPSLHWREISSGRLELEWQHPSPWAAQETCYQLRYTGEGHEDWKKTEACFVALTSRPTPGPRPVP
Protein: RhoGAP1A (Q6W434)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
XEXNTXFFKIDELYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLQTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSVRDQLAMEVANSGSGGFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLK
Protein: Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2) (A4Z6H1)
Organism: Sus scrofa (Pig)
Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03127}. Mitochondrion {ECO:0000269|PubMed:17347008}.
Interaction partners:
- Adenylosuccinate lyase
- Bifunctional purine biosynthesis protein ATIC
- GMP reductase
- GMP reductase
- Inosine-5'-monophosphate dehydrogenase
- Trifunctional purine biosynthetic protein adenosine-3
- AMP deaminase
- AMP deaminase
- Hypoxanthine-guanine phosphoribosyltransferase
- Inosine triphosphate pyrophosphatase
Sequence:
MAFAETNPAASSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMERIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHFPANQEVLNKVEVQYKTLPGWNTDISNARTFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF
Protein: Sll1307 protein (P73596)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Interaction partners:
- Sll1305 protein
- Sll1784 protein
Sequence:
MLKFTFTPLLTTIALTGLALPALALEETPVLPAEIAIKAAQSAIAACRQEGYGVTATVVNPEGNVLVVIRSDGALVHTVQTSFNKAYSAVTLATNHNLDRTSGILASMQAKGAQGVGTWPMPADPLTGITLFPGGVTLISQGKVVGGLGVSGTPIGMVDEGCAIKGRDAVLPDLR