wanglab/gogpt-training-data huggingface dataset:
Protein: Syntaxin-18 (Cell growth-inhibiting gene 9 protein) (Q9P2W9)
Organism: Homo sapiens (Human)
Function: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:15029241}; Single-pass type IV membrane protein {ECO:0000305|PubMed:15029241}. Golgi apparatus membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Interaction partners:
- Centromere/kinetochore protein zw10 homolog
- Vesicle transport protein USE1
- Vesicle-trafficking protein SEC22b
- Vesicle transport protein SEC20
- Sec1 family domain-containing protein 1
- RAD50-interacting protein 1
- NBAS subunit of NRZ tethering complex
- Syntaxin-5
- Alpha-soluble NSF attachment protein
- Syntaxin-6
Sequence:
MAVDITLLFRASVKTVKTRNKALGVAVGGGVDGSRDELFRRSPRPKGDFSSRAREVISHIGKLRDFLLEHRKDYINAYSHTMSEYGRMTDTERDQIDQDAQIFMRTCSEAIQQLRTEAHKEIHSQQVKEHRTAVLDFIEDYLKRVCKLYSEQRAIRVKRVVDKKRLSKLEPEPNTKTRESTSSEKVSQSPSKDSEENPATEERPEKILAETQPELGTWGDGKGEDELSPEEIQMFEQENQRLIGEMNSLFDEVRQIEGRVVEISRLQEIFTEKVLQQEAEIDSIHQLVVGATENIKEGNEDIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS
Protein: F-box and leucine-rich repeat protein 22 (D3ZS59)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
Sequence:
MHITQLNRECLLRLFSFLDKDSRKSLSRTCSQLRDVFEDPTLWSLLHFHSLTELKKDNFRLSPALRSLSICWHSSRVQVCSIEDWLKSAFQRSICSQHENLVNDFLLQVCNRCPNLASVTLSGCGHVTDDCLARLLLGCPRLRALRLENCARVTNRTLAAVAAHGRALQTFHVDFCRNVSAAGLLRLRAACPNLILSAEHSAAMIPDQPPRARASPASVFSPAPGRQSAPHPTGFY
Protein: ABC-type dipeptide transporter (EC 7.4.2.9) (Q9HVR6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004417}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004417}.
Interaction partners:
- Probable permease of ABC transporter
- Probable permease of ABC transporter
- ABC-type dipeptide transporter
- Probable binding protein component of ABC transporter
- Dipeptide-binding protein
- Probable binding protein component of ABC transporter
- Tripeptide-binding protein
- Glycine-glutamate dipeptide porin OpdP
- Probable binding protein component of ABC dipeptide transporter
- Probable ATP-binding/permease fusion ABC transporter
Sequence:
MSLLDIKNLSVRFGDTTAVPVVDGLDLSVDKGEVLAIVGESGSGKSVTMMALMGLIDAPGWVSADHLRFDGHDMLTLKGRQRRRIVGKDMAMVFQDPMTALNPSYTVGYQIEEVLRLHLGLRGKALRQRALELLERVEIPAAASRLDAYPHQLSGGMSQRVAIAMAIAAEPKLLIADEPTTALDVTIQAQIMELLLNLQRDQDMALILITHDLAVVAETAQRVCVMYAGEAVEIGGVPALFDRPTHPYTEALIKAIPEHCAGEARLATLPGIVPGRYDRPRGCLLSPRCPYAQEHCRQERPALETHERGAVRCFYPLNLLNEVA
Protein: UDP-glucuronosyltransferase (EC 2.4.1.17) (Q5DSZ8)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Membrane {ECO:0000256|RuleBase:RU362059}; Single-pass membrane protein {ECO:0000256|RuleBase:RU362059}.
Interaction partners:
Sequence:
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Protein: Submandibular gland secretory Glx-rich protein CA (GRP-CA) (P08568)
Organism: Rattus norvegicus (Rat)
Function: GRP proteins have a marked affinity for hydroxyapatite. They may play a role in the formation of the protective acquired pellicle at the saliva-tooth interface.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MLVVLLTAALLALSSAQGTDEEVNNAETSDVPADSEQQPVDSGSDPPSADADAENVQEGESAAPANEEPPATSGSEEEQQQQEPTQAENQEPPATSGSEEEQQQQEPTQAENQEPPATSGSEEEQQQQEPTQAEDQQPPATSGSEEEQQQQESTQAENQEPSDSAGEGQETQPEEGNVESPPSSPENSQEQPQQTNPEEKPPAPKTQEEPQHDSGRPKKPLLPFIANLIRERIRKLLARSPLGRRF
Protein: Two component sensor histidine kinase (EC 2.7.3.-) (A0A0H3LI47)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Interaction partners:
Sequence:
MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ
Protein: Killer cell lectin-like receptor 4 (Lymphocyte antigen 49d) (Ly-49d) (T-cell surface glycoprotein Ly-49D) (Q60651)
Organism: Mus musculus (Mouse)
Function: Receptor on natural killer (NK) cells for class I MHC.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- TYRO protein tyrosine kinase-binding protein
- H-2 class I histocompatibility antigen, D-B alpha chain
- Killer cell lectin-like receptor 6
- Hematopoietic cell signal transducer
- Natural cytotoxicity triggering receptor 1
- Killer cell lectin-like receptor subfamily B member 1C
Sequence:
MTEQEDTFSAVRFHKSSGLQNEMRLKETRKPEKARLRVCSVPWQLIVIALGILISLRLVTVAVLMTNIFQYGQQKHELKEFLKHHNNCSIMQSDINLKDELLKNKSIECNLLESLNRDQNILCDKTRTVLDYLQHTGRGVKVYWFCYGMKCYYFVMDRKPWSRCKQSCQNSSLTLLKIDDEDELKFLQLVVPSDSCWIGLSYDNKKKDWAWIDNRPSKLALNTTKYNIRDGGCMFLSKTRLDNNYCDQSFICICGKRLDKFPH
Protein: Ciliary microtubule-associated protein 3 (Protein pitchfork) (Q9D9W1)
Organism: Mus musculus (Mouse)
Function: During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.
Subcellular location: [Isoform 1]: Golgi apparatus, Golgi stack. Golgi apparatus, trans-Golgi network.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20643351}. Cytoplasmic vesicle {ECO:0000269|PubMed:20643351}. Note=Accumulates specifically at the basal body and ciliary necklace during the early steps of cilia assembly and disassembly, when structural, functional and regulatory proteins are delivered to cilia. At S phase, accumulates in vesicles and declines during mitosis. In node pit cells, found close to the ciliary membrane along the axoneme. In spermatocytes, localizes to particles along the stabilized microtubules of tails. {ECO:0000269|PubMed:20643351}.
Interaction partners:
- Dynein light chain roadblock-type 2
- G-protein coupled receptor-associated sorting protein 2
Sequence:
MNTEEIPVAPPLRGVTPALQWKVNNYSFGTRQARKLFPHYHPPTWLGNLYLPLRGMPHTGPGCYAAATDWNGLAYNLSKVPTSTKGYAIGARTAVRFKPISKDVTPYPGMYQKVDTLSEKHKKSFAPFNILMPRFRSAAKGDSYPGPGTYNPEMKSVPKVTWPMKFGSPDWSQVPCLEKRTLKAELSADKDFRKHRSRVAYFSLYYQ
Protein: Chemosensory protein B 93b (Q8IN27)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Transcription initiation factor IIA subunit 2-2
- Chemosensory protein B 93a
Sequence:
MDRQQVTLLNILISLTLQIISPSFALNHFFIPEREELFSECLDKPGFSYVNELADLSRFNRKKDADGAMNISGNITMLWDVEPSNRVAVEVNIEKFEGGTWNPTLFKGGDKDFCKNFYDKNTIYYPFSTKHVINKQQVKDKCITTPGTVLVLEPFILKILINFAVPLSPGIHKAVIIFSAFDKSGVKRPRDTCIEIVGEIVNI
Protein: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (FP) (Succinyl coenzyme A synthetase flavoprotein subunit) (Q94523)
Organism: Drosophila melanogaster (Fruit fly)
Function: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q0QF01}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q0QF01}; Matrix side {ECO:0000250|UniProtKB:Q0QF01}.
Interaction partners:
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase cytochrome b small subunit, mitochondrial
- RH44771p
- AT18465p
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- AT02348p
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 23 kDa subunit
- Mitochondrial-processing peptidase subunit beta
Sequence:
MSGIMRVPSILAKNAVASMQRAAAVGVQRSYHITHGRQQASAANPDKISKQYPVVDHAYDAIVVGAGGAGLRAAFGLVAEGFRTAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSYDCNYFVEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGYGRAFFSCTSAHTCTGDGTAMVARQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGERFMERYAPVAKDLASRDVVSRSMTIEIMEGRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMIFAGVDVTREPIPVLPTVHYNMGGVPTNYRGQVITIDKDGKDVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFGRACAKTIAELNKPGAPAPTLKENAGEASVANLDKLRHANGQITTADLRLKMQKTMQHHAAVFRDGPILQDGVNKMKEIYKQFKDIKVVDRSLIWNSDLVETLELQNLLANAQMTIVSAEARKESRGAHAREDFKVREDEYDFSKPLDGQQKKPMDQHWRKHTLSWVCNDNGDITLDYRNVIDTTLDNEVSTVPPAIRSY
Protein: IP13216p (RE16861p) (Tank, isoform A) (Tank, isoform B) (Q9VR33)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Hexosyltransferase
- Carbohydrate sulfotransferase
Sequence:
MAAIKNITLGILYGLWDSIRGMTLVLHIDDEVNRQNAEQEHRQQLRRTDKDRYERARRSPSPVPSSAAAMIREEYAKQAEENADERTLEKILGKKPAAQDQHPQGEKKIAKKLFKCCMLNGGFTWLSIVLFENALLPTLKFCLTIFYGAHSETLPVVWGWLHPILSLLFGMMWVLPIFMLSKIVSSLWFADIANAAYRVRKGRPQLIPGISKLVADFLFSMVVQMLFLVQSMLVNLVPVKYVGSSLCFVHLCLLYSLYSFEYKWFNMGWELHRRLTYIEKNWPYFFGFGIPLTVLTNLSSSVIVSSCIFSIFFPLFILSGNEAKPIVDTTEVSLRLFSPVVFISNLCFGGNPWSKANRLSAMQRQQYELQQRQRLLQRDEQLLKQRKQQYVQQQRLQQEQLMRRDRSHSRSQTPQLGHPHRYAQAPVFDAGRVRDSSASSTHSSNAPSINSHRPPPYYGSSLRGAAPLVPTPVPGAPRAPLTPPVIRQESGPDDWNL
Protein: RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein homolog) (mBLM) (DNA 3'-5' helicase BLM) (RecQ helicase homolog) (O88700)
Organism: Mus musculus (Mouse)
Function: ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity). Recruited by the KHDC3-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks.
Subcellular location: Nucleus {ECO:0000269|PubMed:29125140}. Note=Localized to DNA replication forks, especially after DNA damage. {ECO:0000269|PubMed:29125140}.
Interaction partners:
- Fanconi anemia group M protein homolog
- DNA topoisomerase 3-alpha
- RecQ-mediated genome instability protein 1
- Replication protein A 70 kDa DNA-binding subunit
- Replication protein A 14 kDa subunit
- Exonuclease 1
- Replication protein A 32 kDa subunit
- DNA mismatch repair protein Mlh1
- DNA repair protein RAD51 homolog 1
- DNA replication ATP-dependent helicase/nuclease DNA2
Sequence:
MAAVPLNNLQEQLQRHSARKLNNQPSLSKPKSLGFTFKKKTSEGDVSVTSVSVVKTPALSDKDVNVSEAFSFTESPLHKPKQQAKIEGFFKHFPGRQQSKGTCSEPSLPATVQTAQDTLCTTPKTPTAKKLPVAVFKKLEFSSSADSLSDWADMDDFDMSASDAFASLAKNPATRVSTAQKMKKTKRNFFKPPPRKANAVKTDLTPPSPECLQVDLTKESEEEEEEEEEAEGADCLSRDVICIDNDSASEELTEKDTQESQSLKAHLGAERGDSEKKSHEDEAVFHSVQNTEYFEHNDNDYDIDFVPPSPEEIISTASSSLKCSSMLKDLDDSDKEKGILSTSEELLSKPEEMTTHKSDAGTSKDCDAQQIRIQQQLIHVMEHICKLVDTVPTDELEALNCGTELLQQRNIRRKLLAEAGFNGNDVRLLGSLWRHRPDSLDNTVQGDSCPVGHPNKELNSPYLLSHSPSTEECLPTTTPGKTGFSATPKNLFERPLLNSHLQKSFVSSNWAETPRMENRNESTDFPGSVLTSTTVKAQSKQAASGWNVERHGQASYDIDNFNIDDFDDDDDDDDWENIMHNFPASKSSTATYPPIKEGGPVKSLSERISSAKAKFLPVVSTAQNTNLSESIQNCSDKLAQNLSSKNPKHEHFQSLNFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSFDIPATYLTGDKTDSEAANIYLQLSKKDPIIKLLYVTPEKVCASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQREGLAALAYHAGLSDSARDEVQHKWINQDNCQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQESGRAGRDGEISHCVLFYTYHDVTRLKRLIMMEKDGNYHTKETHVNNLYSMVHYCENITECRRIQLLAYFGEKGFNPDFCKKYPDVSCDNCCKTKDYKTKDVTDDVKNIIRFVQEHSSSPGTRNIGPAGRFTLNMLVDIFLGSKSAKVKSGIFGKGTTYSRHNAERLFKKLILDKILDEDLYINANDQPIAYVMLGTKAHSVLSGHLKVDFMETENSSSIKKQKALVAKVSQREEVVKKCLGELTEVCKLLGKVFGVHYFNIFNTATLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVIPVLQKYSEWTVPAEDGSPGARGAPEDTEEEEEEAPVSSHYFANQTRNERKRKKMSATHKPKRRRTSYGGFRAKGGSTTCRKTTSKSKFYGVTGSRSASCASQATSSASRKLGIMAPPKPVNRTFLRPSYAFS
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (A0A0R4IL45)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- E3 ubiquitin-protein ligase TRIM8b
- Tripartite motif-containing 59
- Bardet-Biedl syndrome 12
- Bardet-Biedl syndrome 10.
Sequence:
MATSTSLDPELVREVLECPICLETYNQDQLRPKLLQCGHSVCRQCLEKLLASTINGVRCPFCSKVSRMSSISQLADNLTVLKIIDCASACSSNMGLMCKSCKNRLPRQYCCDCSIVLCDICKNEGHQRQGHVVQAIRMAAELRRKDIGAKLSDLREAMGNIQKKKAAIDNVTKSLRMKYKAVQQEYAKAELRLQEELGRSRRAFAASLAEIEKLNAQILEEQTYLLNIAEVQVVSRCDYLTMRIKQTDIALLEEGSNNDEEEDLDLKTNLPVVLKLQDPELVKIENSKSLEVGQLTTKPCNVNVEEEEDGLDFPTATSAPLDIYRDIDMVPAVEEAVCASPGSFKSKSVDGGGPSPGASGGQLCQFVKKMGCKGNLPGMFNLPVSICVTLQGEVLVADRGNYRIQIFNRKGFQREIRRNPSSIDNFVLSFLGADLPNLIPLSIAITAQGLIGVTDNYDNSVKVYTTDGHCIACHKNQLIKPWGIAAMPSGQFVVSDVEGGKLWCLAVDRNVGVVNYNRLCSAVRPKFVTCDSSGTVYFTQGLGLNIENRHNEHHLEGGFSIGSVGMDGQLGKQLSHFFSETEDFRCITGMCVDSNGDLIVTDSGRKEILQFPKEGGYNILIQEGLTCPVGVAVTQKGQLLVLDCWDHCVKVYTYLQRRRSSTC
Protein: Mitochondrial phosphate transporter (Os02g0767500 protein) (O80414)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- ATP synthase subunit alpha
- ATP synthase subunit alpha, chloroplastic
- Probable D-2-hydroxyglutarate dehydrogenase, mitochondrial
- NAD-dependent isocitrate dehydrogenase a
Sequence:
MALSDRSRESLLPSFLYTSSAARSFATGATRFPSPVSPASPAPGAVGGGAPISIQAPREKIEMYSPAFYAACTAGGIASCGLTHMAVTPLDLVKCNMQIDPAKYKSITSGFGVLLKEQGPRGFFRGWVPTLLGYSAQGACKFGFYEFFKKYYSDIAGPEYAQKYKTLIYLAGSASAEVIADVALCPFEAVKVRVQTQPGFARGLSDGLPKFVRSEGALGLYKGIVPLWGRQIPYTMMKFASFETIVEMIYKHAVPVPKSECSKSFQLGISFAGGYIAGVFCAIVSHPADNLVSFLNNAKGATVGDAVKKLGLWGLFTRGLPLRIVMIGTLTGAQWGIYDAFKVMVGLPTTGGVTPAPGAAEKALQASA
Protein: Protein ripply3 (Down syndrome critical region protein 6) (P57055)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MEPEAAAGARKARGRGCHCPGDAPWRPPPPRGPESPAPWRPWIQTPGDAELTRTGRPLEPRADQHTFGSKGAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATIDFYDDESTESASEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGPLPQGVSSRGGKCSSSK
Protein: BolA-like protein 3 (Q53S33)
Organism: Homo sapiens (Human)
Function: Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:22746225}.
Interaction partners:
- BolA-like protein 1
- Glutaredoxin-related protein 5, mitochondrial
- BolA-like protein 2
- Glutaredoxin-3
- NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
- Ferredoxin-2, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- Iron-sulfur cluster assembly enzyme ISCU
- Iron-sulfur cluster assembly factor IBA57, mitochondrial
- Lipoyl synthase, mitochondrial
Sequence:
MAAWSPAAAAPLLRGIRGLPLHHRMFATQTEGELRVTQILKEKFPRATAIKVTDISGGCGAMYEIKIESEEFKEKRTVQQHQMVNQALKEEIKEMHGLRIFTSVPKR
Protein: MADS-box protein (MADS-box transcription factor family protein) (Q7X9H5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- MADS-box protein SOC1
- Agamous-like MADS-box protein AGL11
- MADS-box protein AGL24
- Floral homeotic protein APETALA 3
- Agamous-like MADS-box protein AGL6
- Developmental protein SEPALLATA 3
- Agamous-like MADS-box protein AGL8
- MADS-box protein SVP
- Agamous-like MADS-box protein AGL17
- Protein LEAFY
Sequence:
MVKKGGTKRKIAIETIQKRDSLRVTCTKRREGLYSKASQLCLLSDAQIAILATPPSSESNVSFYSFGHSSVDAVVSAFLSGQRPVPKDNKETREDVGICLTRNNLGLGFWWNDESLARSENPQEISEAIDSMRTLLRNLKELRADEALACNQAFVNDREDLKNNDKCDFVSDHETHDQTLILQSASPICCIPENLNEITQEPNQTLNIQSSTSAICCVPDNSPENFNEITEEQDQIRSICETFCVMDNNAALPEMNLDYDQDIGFDTPFESALNDWFSDNTTHQEISASILNAVVDDQVSVDLTPFSYFQRCLDGDNLRFSDCFKDFANTISAL
Protein: Interleukin-21 (IL-21) (Za11) (Q9HBE4)
Organism: Homo sapiens (Human)
Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:11081504}.
Interaction partners:
- Interleukin-21 receptor
- Cytokine receptor common subunit gamma
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase JAK1
- Interleukin-4 receptor subunit alpha
- B-cell lymphoma 6 protein
- Inducible T-cell costimulator
- Interleukin-2 receptor subunit beta
- Interleukin-2 receptor subunit alpha
- Signal transducer and activator of transcription 1-alpha/beta
Sequence:
MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS
Protein: AMP deaminase (EC 3.5.4.6) (Q961Q7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSFADDSYSFGRCYEYQPDDCKWQATGPRPVATAAVLATNRESSSSTEGRESAVTMERNDADINFQRVSISGEDTSGVPLEDLERASTLLIEALRLRSHYMAMSDQSFPSTTARFLKTVKLKDRINNLPVKEVSESADVHLRHSPMKITNPWNVEFPNDEDFKIKPLNGVFHIYENDDESSEIKYEYPDMSQFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMHVLLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVVTVTNGQQMTLAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLREVFLKTDNYLNGKYFAQIIKEVAFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNKMMKSFQEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPENPLFDNDVPRPEEWTYEENPPYAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRYETLLDELSNIFKVNQTCSIADMNAT
Protein: Uncharacterized transcriptional regulatory protein C1327.01c (Q1MTM9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
Sequence:
MMQQRSGSLSLLSNAVQAGQSSDPMQDDPAKTEPGTPKGYDGSKNSSPASVPSWIHEKTKAGKDRKRLPLACQSCRKKKVKCSGERPSCDQCLKHNIPCIYKSNSTKRSHSRHEEIHHQQQLHLNHQYQHQHKNVAANSIDNLSRQYSQPNHINTHDSVNSPPSYGIMASATNQPLSHPTIVPSSNSSSLLNSTNNISHNPQVSLMSASLSKNLVLDPASPKSVSPDLVYVSSDNPPVSTAASAYSSSLPISDVTRALPLAPASNSQHPSLSSQPVSVPSNTINIPTDSLSIVSNPSQTPAKFDSNRISQVPNSDYSIYSNFNNFPIANHAPSFPQSSVKKLDSSFSPTSLPTFTTNSASSGLSTSYTNNNDTTSDNNSLQAVPRLDPVPSLTLSSTPVAELPPLELRIHLAEVFFHCCHGQSYNLFHRPTFFESLNNNTVPLVVVYAVCAVSARFSSRMHDRFSPPYMAGEQYAREARRLALDNFDRPDLSLVAALLLLSLHDSGTCETGKSWMYGGMALRMAAALQLNCEQGSNPLDLDNIDSGPRISFLERELRRRTFWSCFLMDRYASSHEHLQFLDENDIGIQLPVHELLFTKQIAGVTQTLDGRILEGVPSIVIPADTTENMGVAAYTVKIIALWGRAVKYLKQDGKRRDPYPYWHRNSDFSHISEALYAWADGLPQRLKYSAVGLENHLSIQQGAQYAFLHLAYHHTLMWLFRSIGETENNQLSKISSSVSLAGNTVSFSPVSHTPINVTNGESQNNSNNDPSANGAARRLHKAAREICLRCANAISMIVDDCRKHNVILTSPFIASGVYTAFCVQAEAAFGSNVLAASTARHNLEIDLRLMLEMKNYWGSISALCDKMSEIWADWVQRTSSGIQEEDTIPNEMIDEERMLDLEKHFMYITESPIVPNQAAQKSYSPDLMSYFGFAKNSDLQQWNGLWPSDDLRNYQESTIDSLVAYATGNPGWNISFAG
Protein: Trans-4-hydroxy-L-proline dehydratase activating enzyme (EC 1.97.1.-) (Glycyl-radical enzyme activating enzyme PflE) (GRE activating enzyme) (A0A069AMK2)
Organism: Clostridioides difficile (Peptoclostridium difficile)
Function: Catalyzes activation of the trans-4-hydroxy-L-proline dehydratase under anaerobic conditions by generation of an organic free radical on a glycine residue, via a homolytic cleavage of S-adenosyl-L-methionine (SAM). Is involved in the anaerobic degradation of 4-hydroxyproline.
Interaction partners:
Sequence:
MNPLVINLQKCSIHDGPGIRSTVFFKGCPLECVWCHNPESQTYTKQVLYNEERCSKCEACINICPHKAIYKGETKICLDQDKCEFCETCLDYCVNNAREIVGQEYSVRDLVKEIEKDRIFYEESGGGVTLSGGEVMAQDMDFICGVINMCKSKGIHVAIDTCGYAKSENYERVAKCADLFLYDIKLIDEDKHIKFTGKSNDLILKNVKILSELGANINIRIPLIVGVNVDDENLEVKKMIEFLKPLNIQAVSLLPYHNIGKHKYDKIYKKYEGEELQRPSEEKLEEIKRLFEASNFNTKIGG
Protein: MYB transcription factor (Myb domain protein 103) (Putative MYB family transcription factor) (Putative transcription factor) (Q9SRB0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- NAC domain-containing protein 12
- NAC domain-containing protein 73
- NAC domain-containing protein 43
- NAC domain-containing protein 10
- Homeobox protein knotted-1-like 7
- NAC domain-containing protein 30
- NAC domain-containing protein 66
- Cellulose synthase A catalytic subunit 4
- Cellulose synthase A catalytic subunit 8
- Cellulose synthase A catalytic subunit 7
Sequence:
MGHHSCCNQQKVKRGLWSPEEDEKLIRYITTHGYGCWSEVPEKAGLQRCGKSCRLRWINYLRPDIRRGRFSPEEEKLIISLHGVVGNRWAHIASHLPGRTDNEIKNYWNSWIKKKIRKPHHHYSRHQPSVTTVTLNADTTSIATTIEASTTTTSTIDNLHFDGFTDSPNQLNFTNDQETNIKIQETFFSHKPPLFMVDTTLPILEGMFSENIITNNNKNNDHDDTQRGGRENVCEQAFLTTNTEEWDMNLRQQEPFQVPTLASHVFNNSSNSNIDTVISYNLPALIEGNVDNIVHNENSNVQDGEMASTFECLKRQELSYDQWDDSQQCSNFFFWDNLNINVEGSSLVGNQDPSMNLGSSALSSSFPSSF