wanglab/gogpt-training-data huggingface dataset:
Protein: Rab3 interacting molecule, isoform P (A0A0B4K6B1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRRKQDEVVTLEMQIRQRSEQQKKAGVELDATCHICLKTKFADGVGHICHYCNIRCCARCGGKVTLRSNKVIWVCILCRKKQELLSKTGQWINKTAAQQDGFIRRIEPDGSSDISQHPIVDPHDTTDKRPKLERTRSAAEKENLPMQRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNERDLLSSGGGGGGGVGGADFRHLSHATQRLYASADQRDRYELQLQHRERLEQYPLTRTARLDVQQRNSLNRSNHERQFSGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSSYYPQSKPQIVIGPGSGYDRGSGSMASMASAAAATAADAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPATSSSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKSLDAVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNTRLIGHMILRKYYDGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYGANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSFPRNWRNLFGVRNSFLGGAGGEPITGLRLHHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAALAAADSPPISAGIGIQPPHQVLVTDANSGQLVEQFYVEPGTMAEEMMEPLDPHLHPHSVFYSPSPHLPPQPFDIDIDTIYPPRRSNGLKPNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPAGVHPHAHDHTSTTPSSLVGYVRDHQDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEPPSSDPAMCGECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSVLRLSRQLSEDALVAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTKSWGRRRIRYEDEVMPSSGDYPYPHSNPYSSYSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSHFLVTDDKIVTITYDSDVGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYLKRRRNLPHPPSAQNAHNFSPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHHNSQASSVSVSQSHNQQLQQQQQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGGTNANNASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQSQQQQLQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNNTNEPNATTTTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLSDTANDRKKGGGVDQERSPKGGSGMGKKSNSTSQLSATGRKRRMGFGKKGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQFFGDGAGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLGRPIVWAGESVIMEEPGE
Protein: Transcriptional regulator (Q7ME71)
Organism: Vibrio vulnificus (strain YJ016)
Interaction partners:
- Competence protein ComFB
Sequence:
MGLFSRLFGSSKDSEAKKEIEPIEHKGFLIYAESLQEGGQYRVAGRITKEVEGELKSHRFIRSDVLTSEADANELMVKKAQMFIDQMRGEIFS
Protein: VWFA domain-containing protein (G4S4A1)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MRVVHLLVVLATYVSTTSSFNKESIKECAKVLSEHMKETFSKISHETILKQNYEKLVEEEQFDPRAELKKSKHRIEDYLKVRSQFAYKAKISLEARSVRNDSTVNDPQSKSFIRFMSAKQGNDGTTIYESNHLGKRLKVNETKSFNLTQNANFYTLPTSSVSSAVHIPTPLYDRNEDLLRKIDWSDIDAVYRTNREETKDLAFQLFCSEAGYMRYYPAASWFWDNQDEHLDLFDCRNTEWYINSATNSKNVLIMLDMSGSMLGQRYEVAKQTTEAILETLSHNDYFNIMTFSKNTFLLDGCNGTNGLLQATMRNKKALRRKMDTYQSEGKAEYEKALPLAFSVLLDINNGGGDNNRGACENVIMLITDGAPNAYKKIFDMYNADKKVRVFTFLVGDEAIDFNEVREMACNNRGYMVHVANMADVDEKIHHYIRRMSRVVGRHYKESGQLSWWTGVYRERLYLPRPEIFAEPVPITNQSFAVMNKMASRRKIRLQKSEARSRMFVTTVSYPVIVNETFMGVAAVNIPLTEVAQKSHPANIGSKSYFFMLDQNGFVMTHPQLRPIDPFTKYHKQNYNNMDLLELEVGQNQNVRSSQKSQAVSDLVCESGANYAECVDDLRKAVRKMIIDCDNSDVQQLDVLYATELLDRVYPQTNTYYAECINHANFVLGLAVAKGDDYRVVKKQKKYDFGRVKMDWMGDKRWRLHPHWRYCFLNDTDTHMSKEEAFEIYAQQMSDSGKAPLLCEYRRNLVEKLLLDMEATSNLIDSWDTQFNFMKNNLIHLAFFATPSGMIRYYNLTLQDYDYIDPYWSIFEHIGHLLSIEHAQESYNHFITDLNRKSTDDRYYRRAVRMKDTIMFDVSNNSKIWYKSETQLTGYGLNENLTMLGQAFKAIYLDKAVLGVSGFEFAYDHVVDTMAEHGCPASDDRKWCVLLDEHAYVFFSNQNDISYEDYLVGKGKHISQYFGGLNRIAQRAMALLVENKFYTKLTYTDNQAVCKAEKVVTTSGNRLRPFYPIFRFLMQTFNFMVRLASQISGGFLIWLPNIQFTEAYTASFHEGTDVYPCPKQSSFYFSNKDGKNRPGTTHLVNGNRSERPCKMNAKCSVKMEASFVDGTNLVMVWITQDKASENCYDESECSMEISNQVPFGFEEVKNEETCEENEKRKSKANDVCYSIDDDDSENERRPCSTSPTIVSIFQILFGVFLHFCIF
Protein: Motility gene repressor MogR (P0DJO8)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Function: Transcriptional repressor of flagellar motility genes, such as flaA, during extracellular growth at 37 degrees Celsius and during intracellular infection. Binds directly to the gene promoter region and probably prevents RNA polymerase binding. At low temperatures, MogR repression activity is modulated by the DegU response regulator in an unknown mechanism. Required for full virulence.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15302931}.
Interaction partners:
- Lmo0688 protein
- Lmo0673 protein
Sequence:
MPKSEIRKLLQEIKKQVDNPGNSSTTEIKKMASEAGIDEQTAEEIYHLLTEFYQAVEEHGGIEKYMHSNISWLKIELELLSACYQIAILEDMKVLDISEMLSLNDLRIFPKTPSQLQNTYYKLKKELIQVEDIPKNKPGRKRKTQKNTKKEKTNIFGKVVPAEFKAPASIKEQISYDKSREKNLVDLLSGVKSNVQLLSENQGEENNVYDLLKSIYSLSSLAVQKEELDKKYQDLQTKCQELEQENSYLKQQNETMTDSFHTLVLQVADFAYASDLDQIQALPLFSQQLVVTLNQLGVFKENYKQM
Protein: Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) (Q80Y83)
Organism: Mus musculus (Mouse)
Function: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
Subcellular location: Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q155Q3}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q155Q3}. Cytoplasm {ECO:0000250|UniProtKB:Q155Q3}. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis. Associated with actin stress fiber at the filament ends. {ECO:0000250|UniProtKB:Q155Q3}.
Interaction partners:
- Disrupted in schizophrenia 1 homolog
- Axin-1
- Segment polarity protein dishevelled homolog DVL-1
- Nuclear distribution protein nudE-like 1
Sequence:
MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPSVKPVQDLRQDLRDGVILAYLIEIVGQLALDSDASVDERTDFFLLHSPFKAAGEKLTGVQLSPSNQQEMKSNVERVLQFVASKKIRMHQTSAKDIVEGNLKSIMRLVLALAAHFKPGSSRTVSQGRDSKAPVQSHQPHCATAVAQGAAAALADVCHDVSRSGRDVFRYRQRNASVDGEIENPYWSVRALVQQYEGQQKSPSESSCSSLTSPSPIHSAKSESIITQAEEKADFVIIPSEGIENRTDEPDSPSSRDWRPGSRGTYLEATWEEQLLEQQEHLEKEMEEAKKMISGLQALLLNGSLPEDEQERPVALCEPGVNPEEQLIIIRSRLDQSVEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLEERNRLLGEYKKELGQKDRLFQQQQAKLEEALRKLSDASYQQVDLERELEQKDVLLAHCMKGETDEVTNYNSHSSQRNGFVLPVAGRGATTVTHRGPQTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVVETQKKQERKVGGRSPRNQASSEYRASWPPNSTLPHSQSSPAVSSTCTKVLYFTDRSLTPFMVNIPKRLGEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEVFHDDDAIPGWEGKIVAWVEEDHREN
Protein: Germacrene A synthase (LpGEAS) (EC 4.2.3.-) (Beta-elemene synthase) (EC 4.2.3.-) (T1RRI5)
Organism: Lavandula pedunculata subsp. lusitanica (French lavender)
Function: Sesquiterpene synthase involved in the biosynthesis of volatile compounds widely used in aromatherapy and folk medicine, and present in culinary herbs. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into germacrene A and beta-elemene. Not able to use (2E)-geranyl diphosphate (GPP) as substrate.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MAQQEAEIIRPLANFSPSLWGDQFIKNDSDAKVEDKISKTIEVLKEEVKSMLTATGTKMVDTMNLIDTLERLGVSYHFEHEIEEILQQFFNLNTDYNDEAYDLYTVATHFRLFRQHGHRITCADIFGRWRDENGKFHEGLKDDAKGLLSLYEASYLRTRGETILDEALDFTTASLKSIAPNLESPLRRQVEHALVQQLHWGNPRIEARNFISLYEEYEDKDESLLRFAKLDYNLLQMMHKEELHEVSRWWKELDLVAKLPYARDRVVECFFWAMGVYHEPQYSRARVMLTKTIAMTSIIDDTYDAYGTIEELDIFTEAIERWNVEEMKRLPEYIKPFYKALLELYEQFEEELAKEGRSYATHYAIESLKELVRSYHVEAKWFIQGYLPPFEEYLKNALITCTYCYHTTTSLLGVESAVREDFEWLSKKPKMLVAGLLICRVIDDIATYEVEKDRGQIATGIESYMRDNGATKEEAITKFFEIANDAWKDINEECMRPSPHSRDVLMRILNLERIIDVTYKGNEDGYTQPEKVLKPHIIALFVDPIQI
Protein: Serine/threonine-protein kinase receptor (EC 2.7.11.30) (A0A0B4KG59)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.
Interaction partners:
- Protein decapentaplegic
- Inhibin beta chain
- receptor protein serine/threonine kinase
- receptor protein serine/threonine kinase
- receptor protein serine/threonine kinase
- Protein 60A
- Mothers against decapentaplegic homolog
- E3 ubiquitin-protein ligase CBL
- LD29161p
- receptor protein serine/threonine kinase
Sequence:
MSKYDLLYLTAQLTLVCCLIGIHGSILPGSHGIIECEHFDEKMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMHECNQTECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIYIGTSVFSVLMVIVGMGLLLYRRRKQAHFNEIPTHEAEITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKHMDKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPSTQLLIKNHTNIDDAKESTNCLXKRY
Protein: Delta-aminolevulinic acid dehydratase (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) (P05373)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Interaction partners:
- Uroporphyrinogen-III synthase
- 5-aminolevulinate synthase, mitochondrial
- Porphobilinogen deaminase
- Uroporphyrinogen decarboxylase
- C-4 methylsterol oxidase ERG25
- Lanosterol 14-alpha demethylase CYP51
- Protoporphyrinogen oxidase
- Oxygen-dependent coproporphyrinogen-III oxidase
- Ferrochelatase, mitochondrial
- Uroporphyrinogen-III C-methyltransferase
Sequence:
MHTAEFLETEPTEISSVLAGGYNHPLLRQWQSERQLTKNMLIFPLFISDNPDDFTEIDSLPNINRIGVNRLKDYLKPLVAKGLRSVILFGVPLIPGTKDPVGTAADDPAGPVIQGIKFIREYFPELYIICDVCLCEYTSHGHCGVLYDDGTINRERSVSRLAAVAVNYAKAGAHCVAPSDMIDGRIRDIKRGLINANLAHKTFVLSYAAKFSGNLYGPFRDAACSAPSNGDRKCYQLPPAGRGLARRALERDMSEGADGIIVKPSTFYLDIMRDASEICKDLPICAYHVSGEYAMLHAAAEKGVVDLKTIAFESHQGFLRAGARLIITYLAPEFLDWLDEEN
Protein: Arginine decarboxylase 1A, chloroplastic (EC 4.1.1.19) (A0A1S3YCW2)
Organism: Nicotiana tabacum (Common tobacco)
Function: Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN). Required for the biosynthesis of putrescine (By similarity). Catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine from arginine (By similarity).
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Agmatine deiminase
- arginase
- Agmatine deiminase isoform X1
- Argininosuccinate lyase, chloroplastic-like
- argininosuccinate lyase
- Nitric oxide synthase isoform X1
- Nitric oxide synthase isoform X1
- Putrescine N-methyltransferase 4.
- spermidine synthase
- Putrescine N-methyltransferase 1
Sequence:
MPALGCCVDAAVSPPPGYSFLWDSSLPAPEIFPSGVPPSTNTAVATTTTTHWSPAHSSALYSIDGWGAPYFTVNSSGDISVKPHGTDTLPHQEIDLLKVVKKASDPKNLGGLGLQFPLVVRFPDILKNRLESLQSVFDYAVQSQGYEAHYQGVYPVKCNQDRFVVEDIVKFGSGFRFGLEAGSKPELLLAMSCLCKGSHEGLLVCNGFKDAEYISLALVARKLMLNTVIVLEQEEELDLVIDISKKMAVRPVIGLRAKLRTKHSGHFGSTSGEKGKFGLTTTQIVRVVKKLEESGMLDCLQLLHFHIGSQIPSTALLADGVGEAAQIYCELVRLGAGMKYIDCGGGLGIDYDGTKSCDSDCSVGYGLQEYASTVVQAVRFVCDRKNVKHPVICSESGRAIVSHHSVLIFEAVSSTTTRSQELSSVDLQSFVEKLNDDARADYRNLSAAAIRGEYDTCVLYADQLKQRCVEQFKDGDLDIEQLAAVDGICDFVSKAIGASDPVRTYHVNLSIFTSVPDFWAIDQLFPIVPIHKLDERPVVRGILSDLTCDSDGKIDKFIGGESSLPLHELGSNGGGGGDGGKYYLGMFLGGAYEEALGGLHNLFGGPSVLRVSQSDSPHSFAVTCAVPGPSCADVLRAMQHEPELMFETLKHRAEEFVHNDDEQEEDKGLAFASLASSLAQSFNNMPYLVTNSSCCLTAAANNGGYYYCNDENIVGVGAESAAAEEELWPYCVA
Protein: Arrestin domain-containing protein 4 (Q8NCT1)
Organism: Homo sapiens (Human)
Function: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake.
Subcellular location: Early endosome {ECO:0000269|PubMed:23208550}. Cell membrane {ECO:0000269|PubMed:23208550, ECO:0000269|PubMed:23236378}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:23236378}. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000250|UniProtKB:A0A0B4J1F4}.
Interaction partners:
Sequence:
MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAWGPSTCPRASASTAALAVFSEVEYLNVRLSLREPPAGEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPKVPDQSVKRELQVVSHVDVNTPALLTPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLIVPKAAIFQTQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSMDMSWLTLTLPEQPEAPPNYADVVSEEEFSRHIPPYPQPPNCEGEVCCPVFACIQEFRFQPPPLYSEVDPHPSDVEESQPVSFIL
Protein: Mannosyl-oligosaccharide alpha-1,2-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Mannosidase-1) (P53624)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:P39098}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- alpha-1,2-Mannosidase
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- alpha-1,2-Mannosidase
- Klingon
- Uncharacterized protein
- Protein NipSnap
- HDC05827
- LD03007p
- Endoplasmic reticulum lectin 1
- Alpha-mannosidase
Sequence:
MYRISPIGRKSNFHSREKCLIGLVLVTLCFLCFGGIFLLPDNFGSDRVLRVYKHFRKAGPEIFIPAPPLAAHAPHRSEDPHFIGDRQRLEQKIRAELGDMLDEPPAAGGGEPGQFQVLAQQAQAPAPVAALADQPLDQDEGHAAIPVLAAPVQGDNAASQASSHPQSSAQQHNQQQPQLPLGGGGNDQAPDTLDATLEERRQKVKEMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVTLPVSNAS
Protein: Transmembrane protein (Q38EA5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRAGCNVFFFFSGRGLDVSVSNWLLCGPFSSLLLFGGFICKRKFWAVKLIPCRGTETSRKVLTFSVPSSGIRCYRCTALPFFPSSNSLRALCKRSPMSVLRFWQVGRRRRFISPFTRLKAWWMGIEDASLLSRYGEDGPFRSVWIKWRGTIIVAACTAVMFGRMGETSRSNDILDNIELNRQRYYKREFAPEYVPNAPEAVYDGPKGYSYRDEVSGIMVNADGKLTSDLTREERRARLEQSEISSGMVEAARRLRESPRYQRNDS
Protein: General negative regulator of transcription subunit 2 (cell division cycle protein 36) (P06100)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11889048}. Nucleus {ECO:0000269|PubMed:11889048}.
Interaction partners:
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- General negative regulator of transcription subunit 1
- General negative regulator of transcription subunit 4
- Poly
- General negative regulator of transcription subunit 3
- Protein CAF40
- General negative regulator of transcription subunit 5
- Protein CAF130
- DNA-directed RNA polymerase II subunit RPB1
- Exosome complex component SKI6
Sequence:
MEKFGLKALVPLLKLEDKELSSTYDHSMTLGADLSSMLYSLGIPRDSQDHRVLDTFQSPWAETSRSEVEPRFFTPESFTNIPGVLQSTVTPPCFNSIQNDQQRVALFQDETLFFLFYKHPGTVIQELTYLELRKRNWRYHKTLKAWLTKDPMMEPIVSADGLSERGSYVFFDPQRWEKCQRDFLLFYNAIM
Protein: ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1) (Q80YD1)
Organism: Mus musculus (Mouse)
Function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By similarity). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8IYB8}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q8IYB8}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q8IYB8}.
Interaction partners:
- Polyribonucleotide nucleotidyltransferase 1, mitochondrial
- DIS3-like exonuclease 1
- Exosome complex exonuclease RRP44
- Zinc phosphodiesterase ELAC protein 2
- DIS3-like exonuclease 2
- Exosome RNA helicase MTR4
- WD repeat-containing protein 74
- Exosome complex exonuclease RRP42
- Exosome complex component RRP43
- Nuclear valosin-containing protein-like
Sequence:
MSLPRCTLLWARLPAGRGAGPRAAPCSALRALVGSFPGASGRVPCLAASSSASGGSKAPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKILDKFYKRQEIQKLSADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIVLNDICFSAAHVDDLFPFFLRHAKQIFPVLECKDDLRKISDLRIPPNWYPEARARQRKIIFHSGPTNSGKTYHAIQRYLSATSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERLTVEPEGKQATHVSCTVEMCNVATPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGESAAINLVSELLYTTGEEVEVQKYERLTPISVLDHALESLDNLQPGDCIVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQARKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSINEKGEKELEPITTSQALQIAGRAGRFSSHFKEGQVTTMHRDDLALLKDILNRPVDPIQAAGLHPTAEQIEMFAYHLPETTLSNLIDIFVDFAQVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVFDLYLWLSYRFIDMFPDSSLVRSLQKELDAIIQEGVHNITKLIKISESRKLLNLESLPSGDQSRLSGASKSPARRTRGTKSAGNKATEPLSPSDKELPLASRLVQQGLLTADMLRQLQKEWLTQQPEHSREKVGTRRKKKDPDSD
Protein: TANK binding kinase 1 (A0A494C0X2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL
Protein: Always early (Q2PNN5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSRHQLKKPRKMVAAWQNDELFIKRPNFAPRIRISEKPEIQGRVKPGVASKRTENFTKKPSKISVDVSEDEKAKEKEKEQDPYSNDFILGKRLYNFLKYLSSHRWIWCEFVDSFLDKPTLTMGYDMKRFIAEYCPLLHSCFMPRRGWQLVRRNMGKARRFSAAFIELEREELECQRRIVRQLQQHKFNPKENVGYLDQIPKRVPLPLAKDATVSSFLHGNSSEGIVNGTVMGYDPQDYTYLVRFNRNDYAVVLSLPDSQLYSDEETAAVPLSIIMRGNKSSSVISESAKTEKFGNKRYTKELLESVLRVGKLQDVKHKILMDLARMNEDFETFKEIGSSSSRRDAKVTPQRENLQRRYSASMITLHRVNADILEPLRILHDYLVEYQKQDEEEESKRGRPASEVYQKCRMQAEQDLKTAADEKFLKIESDRTQEFVRNLHTILYLNGKLGRENSSNLETIIADLVTHMVDNIQPSLGRKLKDGVDSLEPLRQQVVQIFKDVKKPERFQITQQAPMQTEDGIYNFVVEAQPDTPS
Protein: Nitric oxide synthase (EC 1.14.13.39) (Q90WQ9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
Sequence:
MAFPNMIMNCIYFTIMKMKLLQDDETKLSHQTKPNKWETRANRCPFSIPVRNVKDGSSLKDMLHHQAVKNQPCTSKVCEGSVMTPKALLRGPKVSTLEILPQAIDLINQYYKSFKIPKIEHHLARLEEITMEIDSTGTYQLTVEELAFGARQAWRNAPRCIGRIQWSNLQLFDARKCKTTQEMFQFLCEHLQFATNGGNLRSAITVFPPRKEDGHDFRVWNSQLLKYAGYQMPDGSIQGDPSSVEFTKICIQLGWKPQYGLFDVLPLVLQVNGEDPDLYEIPPHLILEVSMEHPQHKWFQDLGLKWYALPAVSNMLMEIGGLEFPACPFNGWYMGTEIGVRDFCDYQRYNILEKVGRRMGLETHKLSSLWKDQALVTINVAVIYSFQKNKVTITDHHSAAESFMKHLETEFRLRGGCPADWAWLVPPMSGSLTPIFHQEMVNYILSPFFYYQPDPWMTHVWRNGEMCLKKQQISFKAVARAALFSSTLMSRVLAKRVRCTVLYATETGKSQTLAQRLNSMLNGAFNSRLLCMEDYNFSDMEQESLLVVVTSTFGNGDSPGNGESFKKQLFSLQYLRNKLRYCVFGLGSRMYPQFCAFAHAVDAKLEELGAERVTPTGEGDELNGQEEAFSAWALTALKDAYKEFKIQGQLSLQLPGAERFCEAWDPLRHRVAVESCPQDRITALSAIHSKTVFPMKLKSKHNLQSPHSSRSTILVELERERSAEVMNFAPGDHVGVFPGNLPQLVAGILKFLPHTPPTNQCLRLEYRSDTCRDDEKNWQTVGRIPACPLSQALTYFLDVTTPPSQNLLHKLSQLAKQEGHRQRLLTLAKDSQEYTTWKMFRVPNFLEVLEEFPSLELSAAFLLSQLPLLKPRLYSISSSPQLHPNELHLTLTVLNYHTQDGQGPLHHGVCSTWLDTIKKGDLVPCFIYSSGGFHLPAEPSTPVILVGAGSGIAPFRSFWQQRLHDMKHPEFSESPMSLVFGCQSSETDHLYKEETLEMRRRGVLKSVTNAYSRQPGLPKVYVQDVLRERMAEEVLSVLHQKEGHFYVCGGVNMAQGVTLAVQEILSSQLGITLTQAGEYLTQLKIQKRYHEDIFGAQFQK
Protein: Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22) (Q9D6M3)
Organism: Mus musculus (Mouse)
Function: Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (By similarity). Plays a role in the control of glucose-stimulated insulin secretion (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:A0A0G2K5L2}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQAQLSAQGGAQPSVEAPAPPRPTATQLTRDLLRNHGIAGLYKGLGATLLRDVPFSIVYFPLFANLNQLGRPSSEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIWRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA