wanglab/gogpt-training-data huggingface dataset:
Protein: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.7) (A0A0S2Z366)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
Protein: EppA (Peptidase) (I6TWH9)
Organism: Neisseria gonorrhoeae
Interaction partners:
Sequence:
MGPLLPDAHTIISPFGKRVHPILKKVINHKGEDYRGSINTPLLAPFSGRVVESRYQANTVNGKTVGWGHTVVIEAPNGVRYRASHMNGASPLRFGETVSKGQQIGNLGASGGVTGPHLDAMLYSPSGKILPVSAYRGKTLNEIGKIK
Protein: Galactokinase (EC 2.7.1.6) (Galactose kinase) (P0A6T3)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). To a lesser extent, is also able to phosphorylate 2-deoxy-D-galactose and D-galactosamine. Is not able to use D-galacturonic acid, D-talose, L-altrose, and L-glucose as substrates.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00246}.
Interaction partners:
- Aldose 1-epimerase
- UDP-glucose 4-epimerase
- Galactose-1-phosphate uridylyltransferase
- UTP--glucose-1-phosphate uridylyltransferase
- Type IV methyl-directed restriction enzyme EcoKMrr
- Type IV methyl-directed restriction enzyme EcoKMcrA
- Beta-galactosidase
- Small ribosomal subunit protein uS12
- Uncharacterized protein YihR
- Protease 7
Sequence:
MSLKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSLDAPIVAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPALRDVTIEEFNAVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAVIGDKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC
Protein: UPF0651 protein YPL107W, mitochondrial (Q02873)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YPL108W
- Putative uncharacterized protein YPL136W
- Putative 2-hydroxyacid dehydrogenase YPL113C
- Inner membrane assembly complex subunit 17
Sequence:
MIRNQGWSLLYRIYPVRRFTRYSRVDMTFEGNTQDISTSVEERMTTVFGGRLKGEPPRSTSRVLSGGTKKIAGVQVPAKPQEPDNCCMSGCVNCVWEIYSEDLRDWKHRRKEAAEKIAGTKEKWPKDWNPPLGLLHMENVPVELREKKLETDSKKAEQPHDLSAIRSLFPKRKGPLPKSVLAAKRKNIALRHNYEQKDGGDQSVSESDADEGWEDIPVYVKAFAEFESKKRLQKIRRQEEIKKRTALV
Protein: Protein S100-A7 (Psoriasin) (S100 calcium-binding protein A7) (P31151)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8618345}. Secreted {ECO:0000269|PubMed:8618345}. Note=Secreted by a non-classical secretory pathway.
Interaction partners:
- Protein S100-A7A
- Protein S100-A12
- Defensin beta 4A
- Fatty acid-binding protein 5
- Advanced glycosylation end product-specific receptor
- COP9 signalosome complex subunit 5
- Protein S100-A9
- Beta-defensin 103
- Keratin, type I cytoskeletal 16
- Ribonuclease 7
Sequence:
MSNTQAERSIIGMIDMFHKYTRRDDKIEKPSLLTMMKENFPNFLSACDKKGTNYLADVFEKKDKNEDKKIDFSEFLSLLGDIATDYHKQSHGAAPCSGGSQ
Protein: Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) (P04899)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
Interaction partners:
- Guanine nucleotide-binding protein G
- Adenosine receptor A1
- Cannabinoid receptor 1
- Guanine nucleotide-binding protein G
- D
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- G-protein-signaling modulator 1
Sequence:
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Protein: Ras-related protein Rab-5A (EC 3.6.5.2) (P18066)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:2115402}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:2115402}. Early endosome membrane {ECO:0000269|PubMed:2115402}; Lipid-anchor {ECO:0000305}. Melanosome {ECO:0000250|UniProtKB:P20339}. Cytoplasmic vesicle {ECO:0000269|PubMed:2115402}. Cell projection, ruffle {ECO:0000269|PubMed:21419809}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P20339}. Membrane {ECO:0000269|PubMed:2115402}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CQD1}. Endosome membrane {ECO:0000250|UniProtKB:P20339}. Note=Alternates between membrane-bound and cytosolic forms. {ECO:0000250|UniProtKB:P20339}.
Interaction partners:
- Phosphatidylinositol 3-kinase catalytic subunit type 3.
- Early endosome antigen 1.
- RAB guanine nucleotide exchange factor 1.
- Rabenosyn, RAB effector.
- Alsin Rho guanine nucleotide exchange factor ALS2.
- Ras and Rab interactor 1.
- Rabaptin, RAB GTPase binding effector protein 1.
- RAB5B, member RAS oncogene family.
- Ras-related protein Rab-5C
- Vacuolar protein sorting 45 homolog
Sequence:
MANRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPTQPTRSQCCSN
Protein: LRP2-binding protein (Megalin-binding protein) (MegBP) (Q9P2M1)
Organism: Homo sapiens (Human)
Function: May act as an adapter that regulates LRP2 function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12508107}. Note=Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm.
Interaction partners:
- Low-density lipoprotein receptor-related protein 2
Sequence:
MKLTSEKLPKNPFYASVSQYAAKNQKFFQWKKEKTDYTHANLVDKALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKILDSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVHDIPMIAQVTDCLPEFIGRGMAMASFYHARCLQLGLGITRDETTAKHYYSKACRLNPALADELHSLLIRQRI
Protein: Phosphoglycerate mutase-like protein AT74 (At-74) (Q9MAA2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphoglycerate mutase-like protein lacking PGM activity. May play a role in carbohydrates metabolism.
Interaction partners:
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Sequence:
MSPDNKLLPKRIILVRHGESEGNLDTAAYTTTPDHKIQLTDSGLLQAQEAGARLHALISSNPSSPEWRVYFYVSPYDRTRSTLREIGRSFSRRRVIGVREECRIREQDFGNFQVKERMRATKKVRERFGRFFYRFPEGESAADVFDRVSSFLESLWRDIDMNRLHINPSHELNFVIVSHGLTSRVFLMKWFKWSVEQFEGLNNPGNSEIRVMELGQGGDYSLAIHHTEEELATWGLSPEMIADQKWRANAHKGEWKEDCKWYFGDFFDHMADSDKECETEATEDREEEEEEEGKRVNLLTSSEYSNEPELYNGQCC
Protein: Attractin-like protein 1 (Q6A051)
Organism: Mus musculus (Mouse)
Function: May play a role in melanocortin signaling pathways that regulate energy homeostasis.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEPGVRARSGAPQPASPVLWRARPAGGGGASSWLLLDGNSWLLCYGFLYLALYAQVSQSKPCERTGSCFSGRCVNSTCLCDPGWVGDQCQHCQGRFKLTEPSGYLTDGPINYKYKTKCTWLIEGYPNAVLRLRFNHFATECSWDHMYVYDGDSIYAPLVAVLSGLIVPEVRGNETVPEVVTTSGYALLHFFSDAAYNLTGFNIFYSINSCPNNCSGHGKCTTSVSVASQVYCECDKYWKGEACDIPYCKANCGSPDHGYCDLTGEKLCVCNDSWQGPDCSLNVPSTESYWILPNVKPFSPSVGRASHKAVLHGKFMWVIGGYTFNYSSFQMVLNYNLESSIWNVGAVSRGPLQRYGHSLALYQENIFMYGGRMETSDGNVTDELWVFNVRSQSWSTKTPTVLGHSQQYAVEGHSAHIMELDSRDVVMIVIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAIVQGGYGHTSVYDEVTKSIYVHGGYKALPGNKYGLVDDLYKYEVNTRTWTILKESGFARYLHSAVLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKTLPKPNLHRDVNRFGHSAVVINGSMYIFGGFSSVLLNDILVYKPPNCKAFRDEELCRNAGPGIKCVWNKNHCESWESGNTNNILRAKCPPKTAATDDRCYRYADCASCTANTNGCQWCDDKKCISASSNCSTSVRNYTKCHIRNEQICNKLTSCKSCSLNLNCQWDQRQQECQALPAHLCGEGWNHVGDACLRINSSRESYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKFTQQKVSPWVGLRKINISYWGWEDMSPFTNTSLQWLPGEPNDSGFCAYLERAAVAGLKANPCTSMADGLVCEKPVVSPNQNARPCKKPCSLRTSCANCTSSGMECMWCSSTKRCVDSNAYIISFPYGQCLEWQTATCSPQNCSGLRTCGQCLEQPGCGWCNDPSNTGRGYCIEGSSRGPMKLAGVHNSDVVLDTSLCPKEKNYEWSFIQCPACQCNGHSTCINNNVCEQCKNLTTGRQCQECMPGYYGDPTNGGQCTACTCGGHANVCHLHTGKCFCTTKGIKGDQCQLCDSENRYVGNPLRGTCYYSLLIDYQFTFSLLQEDDRHHTAINFIANPEQSNKNLDISINASNNFNLNITWSVGSTGGTISGEETPIVSKTNIKEYRDSFSYEKFNFRSNPNITFYVYVSNFSWPIKIQIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVGAEQTDFLRGPLEGAPKPIAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKPSDNKDKTSGVRNRKHLSTRQGTCV
Protein: Non-homologous end-joining factor LIF1 (Ligase-interacting factor 1) (P53150)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Stabilizes DNL4. Involved in non-homologous repair of DNA double-strand breaks.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA ligase 4
- Non-homologous end-joining protein 1
- ATP-dependent DNA helicase II subunit 1
- ATP-dependent DNA helicase II subunit 2
- DNA polymerase IV
- DNA ligase 1
- Double-strand break repair protein MRE11
- DNA repair protein XRS2
- Pre-mRNA-splicing factor SPP382
- Exodeoxyribonuclease 1
Sequence:
MSQLTEFISCIPVVNEEQNEEDERGLCKIQIEDGAMLETLDENSLSGLRIEKMLVSEGTGIFSKSSFGINDLRIFTGENIDEESKKYVWYELLKMLTGHKVYIASLDEKVVFTKWTCRMQDDEVWKVVMELESSAIIRKIAELTLHPVKKGEIDLFEMADKLYKDICCVNDSYRNIKESDSSNRNRVEQLARERELLDKLLETRDERTRAMMVTLLNEKKKKIRELHEILRQNNIKLSDDDVLDSALINTEVQKPISELNSPGKRMKRRKTVVEPQNLQKKLKDTSRRRANRKISNQSVIKMEDDDFDDFQFFGLSKRPIITAKDKLSEKYDDITSFGDDTQSISFESDSSSDVQKHLVSLEDNGIQISAGRSDEDYGDISGSESETDASAGEKKSSNHSEQSGNDREPCLQTESETDIET
Protein: U3 small nucleolar RNA-associated protein 4 (U3 snoRNA-associated protein 4) (U3 protein 4 required for transcription) (O60161)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized WD repeat-containing protein C2E1P5.05
- Probable U3 small nucleolar RNA-associated protein 7
- U3 small nucleolar RNA-associated protein 6
- U3 small nucleolar RNA-associated protein 10
- rRNA biogenesis protein rrp5
- U3 small nucleolar RNA-associated protein 22
- U3 small nucleolar RNA-associated protein 15
- U3 small nucleolar RNA-associated protein 20
- Probable U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 21 homolog
Sequence:
MDIHRCRFIDYTPSAITAMAFSHKSGQNDSMPNNLLLAVGRASGNIEIWNPRNDWCLKTVLYGGVDRSIEGIVWSTGEEELRLFSIGFSTTITEWNLHTGKPLVNQDSNAGAIWSIAICDETKTLAVGCDDGSCVLFDISGGPGVIEFKRVLMRQTSRILSLDFQTKDHLVGGCADGVIKVWDLSTPNSAIISRMQVDRARKGEAALIWAVKSLRDGTIVSADSSGAVKFWNGKFFTLSQSFKLHLADALCLGVSANGDMVFSSGIDRKTIQYSREGGKREWVSNSFRRFHSHDVRCMAVFECKSLDVLISGGMDMMLAVIPVRQFNRKNHRMISAVPQRPRMAVAPKARLFMLWNDHEVLLWRIGSPGYRFLLKIVLADEENISHAAISPDGELIAISSVLRTKLYQLQYSDENVKVETVEDSFLSNIGASLLSFTVDKNKLILVSNDSEIFLIELSRLDSRQLEVFELSQPTSKKIAPRQRSNVSSMCDGICSIAVSSDGDYFAVADTVGNIFCYSLSNLTYSELPRVNTYVRAMAFRPDVRGRLAVATAGNQVYEFDVQSRKLSEWSKNNSTNMPKEFSQLLDKAFGAFFDSKHPSRFWIWSANWVSFFDLNLQLPAPRAAGKRKIEMNATVDGNLNDKKLANANSNGISNYGTGDSRCFWITHKYRPMLLVGSVGNSELLVVERPIADMLMSKSMPASFYEHKFGS
Protein: Calcium-dependent protein kinase 21 (EC 2.7.11.1) (Q9ZSA2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger. Mediates the phosphorylation and activation of the S-type anion efflux channel SLAC1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12913141}; Lipid-anchor {ECO:0000269|PubMed:12913141}.
Interaction partners:
- Guard cell S-type anion channel SLAC1
- S-type anion channel SLAH3
- Respiratory burst oxidase homolog protein F
- S-type anion channel SLAH1
- Potassium channel GORK channel)
- Protein DMP1
- S-type anion channel SLAH2
- Calcineurin B-like protein 9
- Calcineurin B-like protein 5
- S-type anion channel SLAH4
Sequence:
MGCFSSKHRKTQNDGGEKSIPINPVQTHVVPEHRKPQTPTPKPMTQPIHQQISTPSSNPVSVRDPDTILGKPFEDIRKFYSLGKELGRGQFGITYMCKEIGTGNTYACKSILKRKLISKQDKEDVKREIQIMQYLSGQPNIVEIKGAYEDRQSIHLVMELCAGGELFDRIIAQGHYSERAAAGIIRSIVNVVQICHFMGVVHRDLKPENFLLSSKEENAMLKATDFGLSVFIEEGKVYRDIVGSAYYVAPEVLRRSYGKEIDIWSAGVILYILLSGVPPFWAENEKGIFDEVIKGEIDFVSEPWPSISESAKDLVRKMLTKDPKRRITAAQVLEHPWIKGGEAPDKPIDSAVLSRMKQFRAMNKLKKLALKVIAESLSEEEIKGLKTMFANIDTDKSGTITYEELKTGLTRLGSRLSETEVKQLMEAADVDGNGTIDYYEFISATMHRYKLDRDEHVYKAFQHFDKDNSGHITRDELESAMKEYGMGDEASIKEVISEVDTDNDGRINFEEFCAMMRSGSTQPQGKLLPFH
Protein: tRNA N(3)-cytidine methyltransferase METTL2A (EC 2.1.1.-) (Methyltransferase-like protein 2A) (Q96IZ6)
Organism: Homo sapiens (Human)
Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:34268557}.
Interaction partners:
Sequence:
MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
Protein: Transcription factor (A0A0G2JXE8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796}.
Interaction partners:
- E2F transcription factor 4
- Transcription factor E2F5
- E2F transcription factor 6
- Transcription factor E2F1
- Retinoblastoma-associated protein
- Retinoblastoma-like protein 2
- E2F transcription factor 3
- Retinoblastoma-like protein 1
- E2F transcription factor 2
- Transcription factor
Sequence:
MTTKNVGLTSTNAELRGFIDQNFSPTKGNISLVAFPVSSTNSPTKILPKTLGPVNVNVGPQMIISTPQRITNSGSVLIGSPYTPAPAMVTQTHIAEAAGWVPSDRKRAREFIDSDFSESKRSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVSEFTNASNHLAADSQAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEIEKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPAVNSTIQLPFIVINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKIAKSLVPKALEGYITDVSTGPSWLNQGLLLNSTQSVSNLDPTTGATVPQSSVNQGLCLDAEVALATGQFLAPNSHQSSTAASQFSESRGETPCSFNDEEEEDEEEDPSSPE
Protein: Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP) (P54830)
Organism: Mus musculus (Mouse)
Function: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
Subcellular location: [Isoform STEP61]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform STEP46]: Cytoplasm.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase R
- Tyrosine-protein phosphatase non-receptor type 7
- Mitogen-activated protein kinase 10
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 13
- Mitogen-activated protein kinase 11
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 12
- Dual specificity protein phosphatase 3
Sequence:
MCCSERLLGLPQPVEMEAPDEAEGLPSKQKEMPPPPPPSPPSEPAQKLPPQGAGSHSLTVRSSLCLFAASQFLLACGVLWLSGHGHSWLQNTTDLISSSLTVLNHLGPVAWLGSGTWGIPSLLLVSLTVSLVIVTTLVWHLLKAPPEPPAPLPPEDRRQSVSRQPSFTYSEWMEEKVEDDFLDLDAVPETPVFDCVMDIKPETDPASLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLVSPREESAHEYLLSASRVLRAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVRLTSPDPEDPLSSYINANYIRGYSGEEKVYIATQGPIVSTVADFWRMVWQERTPIIVMITNIEEMNEKCTEYWPEEQVVHDGVEITVQKVIHTEDYRLRLISLRRGTEERSLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCSPIIVHCSAGIGRTGCFIATSICCQQLRREGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHAMSLYEKQLSLQSSE
Protein: Elafin (Elastase-specific inhibitor) (ESI) (Peptidase inhibitor 3) (PI-3) (Protease inhibitor WAP3) (Skin-derived antileukoproteinase) (SKALP) (WAP four-disulfide core domain protein 14) (P19957)
Organism: Homo sapiens (Human)
Function: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).
Subcellular location: Secreted.
Interaction partners:
- RAC-alpha serine/threonine-protein kinase
- Loricrin
- Kallistatin
- Involucrin
- WAP four-disulfide core domain protein 12
- Cornifin-B
- Envoplakin
- Small proline-rich protein 2A
- Cystatin-A
- Small proline-rich protein 3
Sequence:
MRASSFLIVVVFLIAGTLVLEAAVTGVPVKGQDTVKGRVPFNGQDPVKGQVSVKGQDKVKAQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ
Protein: Double homeobox B-like 1 (L7MUF5)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MELSCSTGLLEKEARRRRIILTQSQKDTLRVWFEKNPNPDLATRGHLAKELGISESQIMTWFQKHRKIRKQAEFACCSEESQEQEQDKPRVKEARRSRTHFTKFQTDILIEAFEKNRFPGIVTREKLAQQTGIPESRIHIWFQNRRARHPDPGQNTQKTPHPPQSSQGPTQKTVGKLAPSKTLTSSASV
Protein: Chemokine receptor-like 1 (C1BI79)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MIFFAIENKMEMENSTMVYSDVTTGMDIISLVVYCVAFVLGPTGNGLVIYVTSCRIKKNVNSVWFLNLALADFLFTSFLLLYIIYIARGYDWPFGDILCKLNSMVTMLSMFASIFLLAAISLHRCLSTWVVVWAHNKCTPGRAEVICVGIWLASLVCSLPFTIFRKIIHHDNRTMCSYSNPHSSTYRNLVVFRFLLGFLIPFLVIIGSYIAIWIRARRLQKGRTHRSLRIIVSVVLAFFICWMPFHVFQFLDIMEEDNQGLKPVVHIGTPLSASLAFLNSCLNPILYVFMCDEFQKKLRQSVLLAFENAFAEDHGMNFVSSTRSLSSHLSRISRKSESLAPGEGGHLHLTGDQSDSKV
Protein: Myogenic-determination protein (Protein nautilus) (dMyd) (P22816)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play an important role in the early development of muscle.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:1902570}.
Interaction partners:
- Protein daughterless
- Myocyte-specific enhancer factor 2
Sequence:
MTKYNSGSSEMPAAQTIKQEYHNGYGQPTHPGYGFSAYSQQNPIAHPGQNPHQTLQNFFSRFNAVGDASAGNGGAASISANGSGSSCNYSHANHHPAELDKPLGMNMTPSPIYTTDYDDENSSLSSEEHVLAPLVCSSAQSSRPCLTWACKACKKKSVTVDRRKAATMRERRRLRKVNEAFEILKRRTSSNPNQRLPKVEILRNAIEYIESLEDLLQESSTTRDGDNLAPSLSGKSCQSDYLSSYAGAYLEDKLSFYNKHMEKYGQFTDFDGNANGSSLDCLNLIVQSINKSTTSPIQNKATPSASDTQSPPSSGATAPTSLHVNFKRKCST
Protein: FI09619p (Mitotic arrest-deficient 1) (TXBP181-like protein) (Q7KND8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Mitotic spindle assembly checkpoint protein MAD2A
- Bub1-related kinase
- Origin recognition complex subunit 2
- Bub1 kinase, isoform A
- Monopolar spindle 1, isoform B
- Mitotic checkpoint protein BUB3
- Cell division cycle protein 20 homolog
- Protein cortex
- Protein inturned
- Fizzy-related protein homolog
Sequence:
MDDIRSSIDDMMDRFNDSITHSAPKKLLFNRLSASFDLGVSPNKRRRERESPERSLNDTASSLNMPANDSMASLQNSKLRTELIETKAIVIQLRNEIEKKSREHKEAILLAENKSTALKDQCDITSKKNLELQDDLKALRKRELVLKNEASRATAELNQLRLKFDESTLKLQKEKYLQKEDARDVHLCINNELSEYRRIAQRADLELQSTRNELERLRQLNEELQARASGFEQLRANHEKQTQSLKVANDRIQELEFEIQSYSDWKEVVKTSRERLASVPDLLAEVEHLRSHNKHLNTLIGDKLLLEEQVYDYKTRLEREEGARAEAASLQVKLLHMEQELKEWVKVAQDHCLANTLVSPMALRSRIEQLLKEDIIHVAEKTSSASDTKHLNTTIRDLEHKCAIYLKNIEDLNIGLKRHKNFKERLQRKLITVSKERDFYKQLVENFDKDTTLSNASVADMTQDMQVRVRMEVLERTVTGYKDMCATLEREIQSLRQQELVNEPAGEGYDSVKKELDTLRMENDRLRRRKEELEMEMMHRCLRGDFNMKDFKVVHFSENPAAEAYESTKNMMEKLQAEIERLKRRNKKLEDDNEQRLNETTSTGGMTLNFKEFNQLQAELESANGKMRKMRDCFKAAREEFRDVCYMLLGYRIDRIGANSNYRISSMFAEGPDDYLDISLNESNCLALLESPYSHTFNPPIDQQLAASNFPAFFSALTLELFQKATVTMT
Protein: Mitochondrial DNA polymerase subunit gamma-2 (Polymerase (DNA directed), gamma 2, accessory subunit) (E5KS15)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV
Protein: Orf183 protein (Q8HCQ5)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial, putative, expressed
- NAD
- NAD
- Cytochrome c oxidase subunit 3
- NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial, putative, expressed
- Os05g0509200 protein
- NADH dehydrogenase iron-sulfur protein 2
- Os01g0775100 protein
- NAD
Sequence:
MGLRFDKSIEQEIEDFFASKNLDTVAQSPYIGLIRAVELLEKEGDGPAPANGNDAGSPGPAGSERLSSSGSSVNQPEPLTQDLLADAVTYESPNYLSDAESTNSLGPVTDLASPLDPFSIHPIMDLLMGNYYLAFTNESLSMTVTVVFLLLRVYFLYIWVRAAFPRYRYDQLMGLSDDPKLKD
Protein: Unique cartilage matrix-associated protein [Cleaved into: Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C) (Gla-rich protein) (GRP)] (Q8WVF2)
Organism: Homo sapiens (Human)
Function: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Matrix Gla protein
Sequence:
MTWRQAVLLSCFSAVVLLSMLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKRRGKRSPKSRDEVNVENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYNRHHT