wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome c oxidase subunit 7s (EC 7.1.1.9) (Cytochrome c oxidase polypeptide VIIs) (P20610)
Organism: Dictyostelium discoideum (Social amoeba)
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location: Mitochondrion inner membrane.
Interaction partners:
Sequence:
MTHALPKVVKSQLVQDIGVALILGSIAGCFFKYGVDKKKQRERVAFYEKYDKEDL
Protein: Putative B3 domain-containing protein At5g66980 (Q9FGD2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00326}.
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS21y
- Small ribosomal subunit protein eS21z
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein eS1z
- Small ribosomal subunit protein eS1y
- Large ribosomal subunit protein eL38z/eL38y
Sequence:
MVDLSKDLQFFKVFLPEFGSHELVIPPAFIDMLEKPLPKEAFLVDEIGRLWCVETKTEDTEERFCVFFTKGWQSFANDQSLEFGDFLVFSYDGDSRFSVTIFANDGCKKDVGVVSTTDRSRVSLDEEEPDDIFTKPDRMRDCDCGQSINRKRKRDSVNEDPHVLVDDKPEYVSTYKTKPEHSEKTQRTVNRAGDTCDISWFPEKKHNGFEESVYKPKHPHFVRNITRGSLQKLELPLTFLRSNGIELEEDIELCDESGKKWPLKILNHDRGFKFSHESWLCFCKSHEMILTNKCLFEFIVPSNGRCSEILVRIVSGRLPTTMTKNNYQVIDMQP
Protein: Amyloid-beta A4 protein (Q6NUZ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU367156}; Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367156}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MRSRELFILLMAVASTLAVEVPSDSGTGLLAEPQIAMFCGKLNMHINIQSGKWEPDPSGSKSCIGNKEGILQYCQEVYPELQITNVVEANQPVSIWDWCKKSRKQCRSHMHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDRSMNLHDYGMLLPCGIDRFRGVEFVCCPADAGKESESAAVEEDDSDVWWGGAEADYTENSMTRDAAAEPAVLEDDEDADEEEDEDQDGDGDRDEKIEEEEEEEERTQSTSAALTSTTTTTTESVEEVVREVCFASAETGPCRAMLSRWYYVREERRCAPFIYGGCGGNRNNFESEEYCLSVCSGVLPTPSSSPPDAVDRYLETPADENEHAHFLQAKESLETKHRERMSQVMREWEEAERQAKSLPRNDKKAVIQHFQEKVEALEQESASERQQLVETHMARVEALLNDRRRLALESYLSALQADPPRPRHVFSLLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRPQVLTHLRVIEERMNQSLGLLYKVPGVADDIQDQVELLQREQQEMSAQLANLQSDARVSYGNDALMPDSTAGLELLPAEDTQGFGFIHPESFNQPNTHNQVEPVDARPVPDLDLATRPVSGLKPDDIPELRMEAEERHSEVYHQKLVFFAEDVSSNKGAIIGLMVGGVVIATIIVITLVMLRKKQYTSIHHGIIEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMHN
Protein: Dynein axonemal assembly factor 19 homolog (Coiled-coil domain-containing protein 103 homolog) (Protein PR46bp) (Q94EY1)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Dynein-attachment factor required for cilia motility.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22581229}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:22581229}.
Interaction partners:
Sequence:
MSSTPDHRPSKVSKELANAACDDFKRKAIDEAKKRAVAQRVDYDTFKNMVLTAHLKPITAPKQLNNDRPLPCWSFGVDGKMLKEQISQSQLPPTTPTEVPTTSGDFTRDWRRNCPTPDDKYRYLKLCGPEGLQAVFRVEISAEVLREMLAVLEACWLGHGGVAEEAEGGAGAALLEAAFVVQVLEAVSTAGRFSLTVKLLGSSAKPTLERLFSGLQSAVLASQAAHQGKQEQPAAAEAPHEEGGSTVDPCSPTRVAALQAMYGLPPS
Protein: Amino acid transporter, putative (Q57UY1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Amino acid transporter, putative
Sequence:
MQVAMPVSLVDSCLGVQELLVLVYSCVWQSLLPLYELARFFSFPFQSSSYQAAHTHTHTRTRTHVHTQQTHLLNMLSPTEPLGSGKAHTEVVTDEGEGYGAMSAADEKSHHKNGDTPTTDSKFMQCINAIIPHGGALSTTFNLGSATLGAGVISLAIAFQMSGVIPSILILITVTVLTIYSVGLMMQAVEMTGYNSYTDLSRNLFGPGWDYFTISVSWLFTFGTCVSYVIATGYLVGSVASGCTTLEFFQGKTGNRVITSIIWFVGMFSLSLPKEINSLRYASAIAVLFVFYFVICIVVHSAKNGLKDGKLPEDVEMFKSGNRAIEGLSIFMFSYLCHMNCFSIYSEMRKPSARRMTLHTTYSMSMCCVVYIIAGFFGYTDVGNKSVETVFEIYDVKGDVMMAIAFAGMLLKICVGFSLCMQPARDCCYYIIGWDLNTLETWKNCLFCGCMALCALLLGLFIPDLNTVFGLLGSFCGGVLGFCIPALYRMYCGNWGISQVGVVNYVCTYLLLISGVIAVVFGTAASIYNVAV
Protein: ANK_REP_REGION domain-containing protein (Q22015)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein transport protein SEC23
- Protein SEC13 homolog
- Small COPII coat GTPase SAR1
- Yeast SEC homolog
- Protein-tyrosine-phosphatase
- Sugar phosphate transporter domain-containing protein
- DOMON domain-containing protein
- Uncharacterized protein F15G9.1
- ribose-phosphate diphosphokinase
- Zinc finger CCCH domain-containing protein 15 homolog
Sequence:
MASLAYSYQEQQLDFLHLCSLGDENRVRNALLSGRVDKNYRHSSNGWTALHWAANRGHYDVVLLLIEDGYALNAEDNKNRTPYDVCPESKDKLKAVLELGEERENMVRSSASRRTSDASEQSSPGFVPNYVRNPPFPYAMKNSFDNFSTPPASSVSNGSGSPGPLNSPTYSYGRRDSFNKTRFLLVRTSVEKGKETYKRVTLPGGSDVERLKTTIEKACKGKKVDMIFTLPENDLVESIDQIHRFKDCQKIDVIFKENDRESTPMVTGDAVNMSEEREVSPKDLVVEKNYGQEDIDIPKNDDHEEQEEPRAPTPAEDLSHYVKEPSPPVSLAATDLDSNNGADEGNGEGHDEPKLIPLTTRQSLDSDPGDFEKVDKEEAAKLADTSPAVAGIAAAIPIISAQVEEEQNDPTVLESEHEPSFVPPASAHQAPSTKATVVEESKQVPEGREPSDLATWIHNNPDVVRNVAAAAAVAGVAGLGYYVYVKKFK
Protein: Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (O55201)
Organism: Mus musculus (Mouse)
Function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription elongation factor SPT4-A
- Transcription elongation factor SPT6
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II subunit RPB2
- RNA polymerase-associated protein RTF1 homolog
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB7
Sequence:
MSDSEDSNFSEEEDSERSSEAEEAEVEEDQRSAAGSEKEEEPEEEEEEEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKEREHNFQPGDNVEVCEGELINLQGKVLSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPRTVGVIVRLERETFQVLNMHGKVVTVRHQAVTQKKDNRFAVALDSDQNNIHVKDIVKVIDGPHSGREGEIRHLYRSFAFLHCKKLVENGGMFVCKARHLVLAGGSKPRDVTNLTVGGFTPMSPRISSPMHPSAEGQHGGFGSPGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVDSQRPGGMTSTYGRTPMYGSQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQIVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIIRMDLEDQQIKILNLRFLGKLLEA
Protein: Golgi microtubule-associated protein, isoform D (A0A4D6K5M0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
- Intraflagellar transport 20
- ADP-ribosylation factor 1
- Grasp65
- Golgi matrix protein 130 kD
- Ras-related protein Rab-2
- Golgin-84
- FI04457p
- Golgin-245
Sequence:
MSWLNSSLSQLKGQLTNLAQEVLAETAGPGDLEYEGHQAGGASVQDAEQQAKTALELLAETQEQKEQLDKRCEEKDREIAALRRELAKSKQKQESQLAASTSATREPQLQNEEPNVEDSWCWEPDGGDEKGATGAGSGDSASRDKESGLVDIALGNDDVVRLNNRIAELEQLNEQLNVSLEELDSQHELAMRDVLEHKTQLAGQVASLKQLQADRLVEHELSNARQQKQLDELRQTSSAAKKQQEELQRRVEQQEAELIEMQDLLDKRRQDTAELIERVRVAETERERLLKDLEETRQAKEKKTSESSSNSSSTGKHSEDEFIVVRQADATGSGSASGSDRDPDADVTSPPSKEKLRDRLVSLESQISELTLANTQLQDAQLEKQLSINMLGEQLVELEKRLRLSEAEKEQLQVNLQLRLQQLTVQNQELKLHAEAEQEGHAQNLEEQLGDLREDNQRLRQELKTSIAQAKFRQAIAEEKQEITDLDDADSEYGTFELDKLRALLQAEIEDRLDSSFPQQKLERAWNALKDRWHRLDLVEQRLVDVQNQQLVSEHEKKTLEADISQYILQCDELMKNNDLLLNELDKYKRNKLETIEEHHEETIVQLEAQLEEARQKLELASLSSQQQMETHLISSPEKTPVDSELLAKMEQKEQEYLQLQEQLAFAKTELDKRNKLLERNGEQLTKQQQQNQADQKKLEELSQLRETLQRRDEDLKELEEQLSAVRQDLDEKSIQMKISQDQHKLQLANLQNQLQADQEKLRELLQLQDKLEQQKELMEVDQNQQITIIKKELAETTNQLSECQERLTVKEAQLAEIQQQLQEVNEERTRLQEQLLTKEQESGLDSELAKRNQELEDQLLAKEQQLQLNQAELEKLQETLRVNEEQLLAKEEQLHAKESQLQSLESQLQGQLAADESQQLQQTIDGLGQEKNELIKVLQQKHQENTQYYAEIQRLQPFEQQVKELVKEREKLQDQVGFLKEKSDILTTNLLTEQTNQRLLQQQQAESQEQQASTLRDLERLRAHLLEIEELHTQETVELQRDLEESRSRQAILEQQVSKSSTAYTSASIRANQQAETLQAQHALLQQQRDELLAKLGQYEDRELKQQAALTNLQCALEQFQNDKDHDIEMATQRIRREMQAQLDRQGQLQLEMSGLQQQLAEANQGLRAAARLSDQLEAGQQTIAVLRDEVESLKEANGQLEQRLSSSESSQTDKIDKSLIKSLLIGYVVSGHAGDKQQVLRMISSVLDFNAQEADKVGLNKQQSSWLGAILGGGSATASAAGSSRGNENLVQAFVQFLEQESQPQAQSRPTLLSMTGQMDGVTSASATTSTAATSGHLPQASSSFSPATPAASQQDPAAPRTPPVGGSPQLLAMGSNEFAPTRNSSSILKDILSDSXLL
Protein: Zinc finger protein C25B8.19c (Q9UTA1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Zinc-regulated transporter 1
- VEL1-related protein SPBPB2B2.15
- VEL1-related protein SPBC1348.06c
- VEL1-related protein AC977.05c
- Glucose-6-phosphate 1-dehydrogenase gcd1
- Alcohol dehydrogenase 4
- Metallothionein zym1
- Low-affinity iron/zinc ion transport protein fet4
- Zinc finger protein klf1
- Mitochondrial transcription factor 1
Sequence:
MSSDNTPSINRRNNENPPQSSLPTTSGIVYNMFPACPYPHVQNPAFHGSVDVPQVAQKAFDPQAATVSESANVSRPTPAPVPPAGNTNTPTTSNSNQNLENNVTSAASMPAILNAAGQLEFSPSTNNALCCCTTVHGHPHMPPNLLAASSARLRLPPISTILGGTFADPTFLAAAAAAAVPHYAHATTGSATDASNTSNGNSNPAAVPAGFLSGYSPLSYAYFVAKANELALANQRQSSEAAEQPSSKNNTSGANPPSSNNQEVTSAPIPAAPIVLPFQQPFYPIVCPGCAQGALPQHIPVPHNTEFAQYQPSSRDLQNHPTVDESRLSSVAPPASNTLNHANGNQAENASESSTSQSNDSQGPANTSYPVSVPLPNDAENNHTLSRNPYIPSLNFKDNMSAELSVVATLASNSAQAHPMGQQSDSNYSDHHNNDKRAHVSRRHSTSRKIAQSHTGSSSTSSAANVRYRCTECLQGFSRPSSLKIHTYSHTGERPFVCDYAGCGKAFNVRSNMRRHQRIHGL
Protein: EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) (Q9BSW2)
Organism: Homo sapiens (Human)
Function: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:20418871}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. Cell membrane {ECO:0000269|PubMed:30814157}. Golgi apparatus membrane {ECO:0000269|PubMed:27016526}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27016526}. Vesicle {ECO:0000269|PubMed:27016526}. Note=T-cell activation-induced elevation of intracellular of Ca(2+) stimulates its transport toward the microtubule organizing center (MTOC) (PubMed:30814157). Histamine stimulation induces a trafficking to the MTOC in a GTP-binding-dependent but Ca(2+)-binding-independent manner (PubMed:31092558). Localizes to Golgi membrane in resting T-cells and upon its interaction with VAV1, is translocated from the Golgi membrane to the immunological synapse via subsynaptic vesicles (PubMed:27016526). Its localization in the Golgi membrane requires isoprenylation and GTP-binding (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}.
Interaction partners:
- Stromal interaction molecule 1
- Calcium release-activated calcium channel protein 1
- Cytoplasmic dynein 1 light intermediate chain 1
- Store-operated calcium entry-associated regulatory factor
- Store-operated calcium entry regulator STIMATE
Sequence:
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSVIGKYVDSRGILRSQSEEEEEVFGIPRRSSLGLSGYPLTEEEPGTGEPGPGGPYPRPLRRIISVEEDPLPQLLDGGFEQPLSKCSEEEEVSDQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCKEESSPSAPDRLFKIVFVGNSAVGKTSFLRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERYRCITQQFFRKADGVIVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLDNEKEREVPRGLGEQLATENNLIFYECSAYSGHNTKESLLHLARFLKEQEDTVREDTIQVGHPAKKKSCCG
Protein: Putative HLA class I histocompatibility antigen, alpha chain H (HLA-12.4) (HLA-AR) (MHC class I antigen H) (P01893)
Organism: Homo sapiens (Human)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MVLMAPRTLLLLLSGALALTQTWARSHSMRYFYTTMSRPGAGEPRFISVGYVDDTQFVRFDSDDASPREEPRAPWMEREGPKYWDRNTQICKAQAQTERENLRIALRYYNQSEGGSHTMQVMYGCDVGPDGPFLRGYEQHAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAARRAEQRRVYLEGEFVEWLRRYLENGKETLQRADPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTVPIVGIVAGLVLLVAVVTGAVVAAVMWRKKSSDRKGGSYSQAASSNSAQGSDVSLTA
Protein: Glutamate dehydrogenase 2, mitochondrial (OsGDH2) (EC 1.4.1.3) (Q33E23)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Mitochondrion {ECO:0000255}.
Interaction partners:
- Ferredoxin-dependent glutamate synthase, chloroplastic
- Glutamate synthase 2, chloroplastic
- Glutamate synthase 1, chloroplastic
- glutamate synthase
- Glutamine synthetase, chloroplastic
- Aspartate aminotransferase
- Aspartate aminotransferase
- Aspartate aminotransferase
- Aspartate aminotransferase, cytoplasmic
- Glutamine synthetase cytosolic isozyme 1-2
Sequence:
MNALAATSRNFRQAARLLGLDSKLEKSLLIPFREIKVECTIPKDDGTLASFIGFRVQHDNARGPMKGGIRYHPEVDPDEVNALAQLMTWKTAVAAIPYGGAKGGIGCAPGELSTSELERLTRVFTQKIHDLIGAHTDVPAPDMGTNSQTMAWILDEYSKFHGHSPAVVTGKPIDLGGSLGRDAATGRGVMYATEALLAEHGKSISGSTFVIQGFGNVGSWAARIIHEKGGKVIALGDVTGSIRNKNGLDIPALMKHRNEGGALKDFHDAEVMDSSELLVHECDVLIPCALGGVLNRENAPDVKAKFIIEAANHPTDPEADEILAKKGVTILPDIYANSGGVIVSYFEWVQNIQGFMWDEEKVNMELHKYMNNSFQHIKAMCKSHDCNLRMGAFTLGVNRVARATLLRGWEA
Protein: SPRY domain-containing protein 4 (Q8WW59)
Organism: Homo sapiens (Human)
Interaction partners:
- Transmembrane protein 192
Sequence:
MALLFARSLRLCRWGAKRLGVASTEAQRGVSFKLEEKTAHSSLALFRDDTGVKYGLVGLEPTKVALNVERFREWAVVLADTAVTSGRHYWEVTVKRSQQFRIGVADVDMSRDSCIGVDDRSWVFTYAQRKWYTMLANEKAPVEGIGQPEKVGLLLEYEAQKLSLVDVSQVSVVHTLQTDFRGPVVPAFALWDGELLTHSGLEVPEGL
Protein: Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (Q9TU27)
Organism: Ovis aries (Sheep)
Function: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P29459}.
Interaction partners:
- Interleukin-12 subunit beta
- Interleukin-12 receptor subunit beta-2
- Interleukin-12 receptor subunit beta-1
- Interleukin-27 receptor subunit alpha
- Interleukin-6 receptor subunit alpha
- Ciliary neurotrophic factor receptor.
- Uncharacterized protein.
- Interferon gamma
- Interleukin-6 receptor subunit beta
- Interferon alpha/beta receptor 1
Sequence:
MCPLRSLLLISTLVLLHHLPHLSLGRSLPTTTAGPGTSCLDYSQNLLRAVSNTLQKARQTLEFYSCTSEEIDHEDITKDKTSTVEACLPLELATNESCLASRETSLITNGHCLSSGKTSFMTTLCLRSIYKDLKMYHMEFQAMNAKLLMDPKRQVFLDQNMLAAIAELMQALNFDSETVPQKPSLEELDFYKTKVKLCILLHAFRIRAVTIDRMMSYLSSS
Protein: Spermatogenesis associated 24 (cDNA FLJ25874 fis, clone CBR02446) (Q8N799)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATPLGWSKAGSGSVCLALDQLRDVIESQEELIHQLRNVMVLQDENFVSKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKSKVLQESSKKDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQIFSPPPAGSVAGITCLTSGSRSSRRATWPRCWTRSIRKPQGHVRPAATSIPGKNKMAAAFLFSGCNPQPLPSLLWESPASSPCYFPPSWIVVGVHKVGACSLGEELGLCCLVGTTASFGYLIPSYINSPGYPV
Protein: Protein ripply3 (Down syndrome critical region protein 6) (Q924S9)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
Interaction partners:
Sequence:
MRPEAAGVREARGRLCHCPGDDPGRLPLPRGPESSIPAPWRPWMSPPPGDAELTRTERPCESWGDQHTSGSKGAFGFQHPVRLYLPVSKRQEYLQSSGEKVLASFPVQATIHFYNDDSESGSEEEQEEEAQPNHLQCLEAEVRDSAQEERAE
Protein: Survival motor neuron protein (O35876)
Organism: Rattus norvegicus (Rat)
Function: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Subcellular location: Nucleus, gem {ECO:0000250|UniProtKB:Q16637}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q16637}. Cytoplasm {ECO:0000250|UniProtKB:Q16637}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q16637}. Perikaryon {ECO:0000250|UniProtKB:Q16637}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q16637}. Cell projection, axon {ECO:0000250|UniProtKB:P97801}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P97801}. Note=Colocalizes with actin and at the Z-line of skeletal muscle (By similarity). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules. Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies. Colocalizes with FMR1 in cytoplasmic granules in the soma and neurite cell processes (By similarity). {ECO:0000250|UniProtKB:P97801, ECO:0000250|UniProtKB:Q16637}.
Interaction partners:
- Gem-associated protein 2
- Probable ATP-dependent RNA helicase DDX20
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein Sm D2
- Serine-threonine kinase receptor-associated protein
- Gem-associated protein 5
- Gem
- Small nuclear ribonucleoprotein F
- GEM
- Small nuclear ribonucleoprotein Sm D3
Sequence:
MAMGSGGGAGSEQEDTVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDMCETSDKPKGTARRKPAKKNKNQKKNATAPLKQWKAGDKCSAVWSEDGCVYPATITSVDLKRETCVVVYTGYGNKEEQNLSDLLSPTCEVANNTEQNTQENESQVSTDDSEHSSRSLRSKAHSKSKAAPWTSFLPPPPPVPGAGLGPGKPGLRFSGPPPPPPPPPPFLPCWMPPFPSGPPIIPPPPPISPDCLDDTDALGSMLISWYMSGYHTGYYMGFRQNKKEGKKCSHTN
Protein: GEO10380p1 (MIP01063p) (MIP01163p) (Metallothionein E, isoform A) (Metallothionein E, isoform B) (B8A3Y2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Metallothionein-4
- Metallothionein-2
- Metallothionein-3
- Metallothionein-1
- Metal response element-binding transcription Factor-1, isoform C
Sequence:
MPCKGCGNNCQCSAGKCGGNCAGNSQCQCAAKTGAKCCQAK
Protein: AT23463p (Q8T406)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGEDSSRRLPRWWFGGVCAAIAVTGTHPIDLIKVQLQTQSQADRKSVGEILKGIHERSGILGFYNGISASWFRQLTYTTTRFALYEAGKDYVDTQKVSSKMALATFAGIVGGIVGVPGDVVTVRLQNDVKLPEEKRRNYKHVFDGLFRIYKEEGVSSLFRGTVPAVSRAVLLTIGTNAAYDQVKQMLKIATGAGEGVPLHFATSTIAGCIAVVITQPLDVIKTTFMNAQPGEFSGIGGAFLSTAKQGPLAFYKGFIPALIRVSPNTIITFVLYEQARMRFGYLPPDK
Protein: Protein arv1 (Q9HDX5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Regulates also the sphingolipid metabolism (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MKCVECGAEVDSLYTYYGRGTSNIRLAQCKNCKQFADKYIELDVVLISMDVILMKPQVYRHLLFNSLSARTFRNVVNFCILISLFNVFLVWSRLEKRAALFPYFTPAQAFLSQPIIRQYLTLLLICLVETTVYQISVVLLLCLTMGWKSWTSASGAVILSSSTRMLPVFMVIWDYDLSIAATVVEWVVLFSNVDALCILTGSRRYFKIGLIVLFASLVRSIVVYIFLHLTGLSQIQPSTPCDGFQHFVNLLCVYFRSITLTAQTAV