wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium/hydrogen exchanger (A9XPA0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MDDTAGTEADKTNPELFTLNYARIKIPFEITLWVLLASFAKIGFNVYHKITVWVPESCLLISLGFVVGGVMHAVRKEPPAVISSNVFFLYMLPPIILESGYFMPTRPFFENVGTVMWFAVVGTLWNTMGIGISLFAICQIEAFGVQDINLQENLLFAAILSAVEPVAVLSVFEDISINEQLYIVMFGECLFNDAVTVVLYNLFNHVAAMEVDEPAVIFMDIGGFFVVGLGGIFFGLLFGFLTAFTTRFTGKVREIEPLVIFMFSYMSYLIAELFALSSIMAILICTLSMKYYVEENVSQRSCTTIRHVIKMVGSVSETLIFFFLGVVSITTEHEWNWGYILFTLFFTLFWRFLGILVLTQIINPFRKIPFNFQDQFGLAYGGLRGALSFALAFTLPNSIPHRKLFITDTIAVIIFTVFIQGITIRPLLKLMNIRKTNRNLETINDEIHKRLMEHTVAGIEDLCGQWSHYRWKDMFMKFNNRFIRKILIRDNRPESSIVSLYKKLELRNALEILDTMSGDISAAPSLMSLYEERKNASKHKKFLPSDVENMHELLSKNMYKIRQRTVSYTNRHSLPNENIAKEILMRRHTTIRSSLRSGSFHATNSANTSHKFCSLPVGQSLNSGFPPGRFRHTDHIDAESETAYPSNRSTFRHQRRSSSKAGIPLRPLNDLREDNEPNEEMPNKMSHPRSKFRHSGHQTSRQYYGTSRNCRDTDFEEQQSSLSPHGWTEEPQNNSDVQHPLMRKPQ
Protein: Afadin, adherens junction formation factor (E9PFY5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTL
Protein: Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11) (Q92743)
Organism: Homo sapiens (Human)
Function: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21297635}. Secreted {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:9852107}. Cytoplasm, cytosol {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:20671064}. Note=Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635). {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:21297635}.
Interaction partners:
- Aggrecan core protein
- E3 ubiquitin-protein ligase XIAP
- Complement factor H
- Age-related maculopathy susceptibility protein 2
- Microtubule-associated protein tau
- ATP-dependent Clp protease proteolytic subunit, mitochondrial
- Pleckstrin homology domain-containing family A member 1
Sequence:
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
Protein: ERAD-associated E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (HMG-CoA reductase degradation protein 1) (RING-type E3 ubiquitin transferase HRD1) (Q08109)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC1 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). In ERAD-L, facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with DER1. Both proteins have lateral gates facing each other which form a channel through the ER membrane and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer. Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1. ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome. ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11018054, ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:11018054, ECO:0000269|PubMed:14562095}.
Interaction partners:
- U1 SNP1-associating protein 1
- UBX domain-containing protein 2
- Ubiquitin-conjugating enzyme E2 7
- DER1-like family member protein 1
- Degradation in the endoplasmic reticulum protein 1
- ERAD-associated E3 ubiquitin-protein ligase DOA10
- ERAD-associated E3 ubiquitin-protein ligase component HRD3
- Cell division control protein 48
- Protein OS-9 homolog
- Nuclear protein localization protein 4
Sequence:
MVPENRRKQLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQHI
Protein: Rapsynoid (Q9NFR7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MSSLSASAENVSSLGLGSGGGGTNSHDGNSQQGSGSDGGSSMCLELALEGERLCKAGDCRAGVAFFQAAIQAGTEDLRTLSAIYSQLGNAYFYLGDYNKAMQYHKHDLTLAKSMNDRLGEAKSSGNLGNTLKVMGRFDEAAICCERHLTLARQLGDRLSEGRALYNLGNVYHAKGKHLGQRNPGKFGDDVKEALTRAVEFYQENLKLMRDLGDRGAQGRACGNLGNTYYLLGDFQAAIEHHQERLRIAREFGDRAAERRANSNLGNSHIFLGQFEDAAEHYKRTLALAVELGEREVEAQSCYSLGNTYTLLHEFNTAIEYHNRHLAIAQELGDRIGEARACWSLGNAHSAIGGHERALKYAEQHLQLAKELHDPVGESTARVNISDLRKLLGMPDSEPSPTEEEARSTASDHSASGNQSDGSGNSQGRMVRVRRQSMEQLDLIKITPDGKRMQEEKLRAQATRKAKDDDFFEMLSRSQSKRMDDQRCSIKVNPSGAPAVATGATRKPLVQQNSLFVDPTNLPGLKSPSSTNPSAIGHGPLARSATTTQQPDDDFLDMLMRCQGSRLEEQRSELPRPNVTMDAEAEAPPRSVPEAAVPGAPRGQTGRGATVPDEDFFSLIMKVQSGRMEDQRASIPFRNANNNNNSRSNNNGSAGGAGK
Protein: Large ribosomal subunit protein eL32 (60S ribosomal protein L32) (P38061)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein eL38
- Small ribosomal subunit protein uS13A
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein eL15A
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein uS4B
- Small ribosomal subunit protein eS19A
- Large ribosomal subunit protein uL30A
- Large ribosomal subunit protein uL22B
- Large ribosomal subunit protein eL13B
Sequence:
MASLPHPKIVKKHTKKFKRHHSDRYHRVAENWRKQKGIDSVVRRRFRGNISQPKIGYGSNKKTKFLSPSGHKTFLVANVKDLETLTMHTKTYAAEIAHNISAKNRVVILARAKALGIKVTNPKGRLALEA
Protein: Elongation factor Ts (EF-Ts) (O51148)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Function: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Elongation factor Tu
- Small ribosomal subunit protein uS2
- Ribosome-recycling factor
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein bL9
- Ribosomal protein S1
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein bL19
- Large ribosomal subunit protein bL21
- Small ribosomal subunit protein uS10
Sequence:
MSIISPQDVKKLREETNAGFGDCKKALSVAGGDFELAKKKLREMGIASAEKRLDRDAKEGRVFSYSNNIYAGLLLVSCETDFVALNHNFVNFGNSLIKELVESGIDSLTTSQELELKNLAATIKENIQVKKIFITKIQSNEFVKIYLHGEQSKIGVLVKLKVNDFSKTEDKIFKNFAMDLALHVAAFAPVYLRNDDVCPNYIKEQEEIFTKQLESSGKPESIIKGIVAGKIKKHLAEISLLEQSFVKNDKITVKEMLEEISKAISSKVEMVEFKYLRIG
Protein: Protein VEL1 (Velum formation protein 1) (P53058)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Note=Intracellular soluble fraction. {ECO:0000250}.
Interaction partners:
- VEL1-related protein YOR387C
- Restriction of telomere capping protein 4
- Protein ZPS1
- Alcohol dehydrogenase 4
Sequence:
MSFLSIFTFFSVLISVATTVRFDLTNVTCKGLHGPHCGTYVMEVVGQNGTFLGQSTFVGADVLTESAGDAWARYLGQETRFLPKLTTIASNETKNFSPLIFTTNINTCNPQSIGDAMVPFANTVTGEIEYNSWADTADNASFITGLANQLFNSTDYGVQVASCYPNFASVILSTPAVNIFGKDDTLPDYCTAIQLKAVCPPEAGFD
Protein: Intraflagellar transport protein 20 homolog (Q66I67)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella.
Subcellular location: Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q61025}. Cell projection, cilium {ECO:0000250|UniProtKB:Q61025}. Golgi apparatus {ECO:0000250|UniProtKB:Q61025}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q61025}. Cytoplasm {ECO:0000250|UniProtKB:Q61025}.
Interaction partners:
- Intraflagellar transport protein 57 homolog
- TRAF3-interacting protein 1
- Intraflagellar transport 80 homolog
- Intraflagellar transport 88 homolog.
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport 52 homolog
- Intraflagellar transport protein 172 homolog
- Intraflagellar transport 74.
- Intraflagellar transport protein 22 homolog
- Intraflagellar transport 81 homolog.
Sequence:
MAKDPLAEAGLHFDELNKLRVLEPDVSQKTTELKEECEEFVDKIGQFQKIVGGLIELVDELAKEAETEKMKAIGARNLLKSVEKQREAQHQQLQALIAEKKMQLERYRIEYEALQKVEAEQSEFIDQFILQK
Protein: Dihydrolipoamide dehydrogenase, putative (EC 1.8.1.4) (Q584K1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Pyruvate dehydrogenase E1 component subunit beta
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- pyruvate dehydrogenase
- Dihydrolipoamide acetyltransferase, putative
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- 3-methyl-2-oxobutanoate dehydrogenase
- 2-oxoisovalerate dehydrogenase subunit alpha
- Aminomethyltransferase
- oxoglutarate dehydrogenase
Sequence:
MISATFHVTTPPHVVLVINTVTTVMIRLCRVCSLRSACVSYIPSNLPRFDVCVIGAGPAGIAAALRAVDYNKRVCLVEAKRIGGCDLWDGALQSKTLWEMSKYVSSLSGASARRVFDDDTVREIQQKLDLSRVQQTLQEVSATRETQTVELLRAAGVTTVFGRAMFSSPHELDVHSPGANEYHVLTADYFIIATGSVPRQHEFVVADHRRVVTTDTIMQLPIPSSLVIIGAGAVGCEFASIYANFGRTEVTIIDKAKRILPKEDEDIANFVEEHLTRRGVRILNTCTLFDLESWEESDDVGGCVYSVRHNTTNNRNDANSVETYEAERALVSLGRTPNLSGLGLENTACKVTGGQVTLDAFGRCVPYKHIYAVGDVSADRGLVNLGEAQGRGAVEHIYGEKPARPVNSSLLTNLSTILFLEEEVACVGLNEEQCRALGFGYIVARYDYSHLSRAIAMGGAQGFCKVIVTNDRQKLLLGVRAVGAHAGSIVEVASLAIRQSDSVYSLLKLTAAYPAVVQGFVECIRMILGRSNIKPNTMPNLTLTEWRPPHGARGRAGGSDASDCAPSSPEVTHEQKEMERNLEATRLEQSVVRQSLKVTEDIERR
Protein: Epididymis secretory protein Li 265 (Tropomyosin 1 isoform 1) (A0A0K0K1I0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSM
Protein: B3 domain-containing transcription factor VAL3 (Protein HIGH-LEVEL EXPRESSION OF SUGAR-INDUCIBLE-LIKE 2) (Protein VP1/ABI3-LIKE 3) (O65420)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in plant development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Lysine-specific demethylase JMJ28
- Subtilisin-like protease SBT3.1
- Pentatricopeptide repeat-containing protein At4g21170
- At5g37840
- Nuclear transcription factor Y subunit B-9
- B3 domain-containing protein REM2
- Lysine-specific demethylase JMJ26
- B3 domain-containing protein REM6
- Trihelix transcription factor ASIL1
- Cysteine-rich receptor-like protein kinase 27
Sequence:
MLSSSSMSSSSLSARFCFNHECFEFKLDHCRPGWRLRSGDFVDLCDRCASAYEQGKFCDVFHQRASGWRCCESCGKRIHCGCIASASAYTLMDAGGIECLACARKKFALGPNFSPSPSFLFQSPISEKFKDLSINWSSSTRSNQISYQPPSCLDPSVLQFDFRNRGGNNEFSQPASKERVTACTMEKKRGMNDMIGKLMSENSKHYRVSPFPNVNVYHPLISLKEGPCGTQLAFPVPITTPIEKTGHSRLDGSNLWHTRNSSPLSRLHNDLNGGADSPFESKSRNVMAHLETPGKYQVVPRFWPKVSYKNQVLQNQSKESESVVTPLFEKILSATDTGKRLVLPKKYAEAFLPQLSHTKGVPLTVQDPMGKEWRFQFRFWPSSKGRIYVLEGVTPFIQTLQLQAGDTVIFSRLDPERKLILGFRKASITQSSDQADPADMHSPFEVKKSAYITKETPGVECSSGKKKSSMMITRSKRQKVEKGDDNLLKLTWEEAQGFLLPPPNLTPSRVVIEDYEFEEYEEAPIIGKPTDVAGSTCTEVEGLLISPTTTKHPRHRDGCTCIICIQSPSGIGPKHDRCCSCAVCDTNKRRRRSLLLRREKKQMEKEDNARKLLEQLNSDNGLHQSANNSENHERHASPLKVQLDLNFKPEKDEESLPGSNKTTKSETLPHDDTVKSSFTSPSSSSAHSQNNKEDEGKLKTTTEIADTTTTSSM
Protein: Uncharacterized protein (Q38BS4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAKGRDSTAHMREFIKRLRARSNVSESPQPQEGEAPPRYARSAITGEVRVVGQKGPLTTSFPSPHRRLLSHVENITATTTSKPEEPPLPPALQIVPDAAEWEQNTGTKQQSCREKPVNPAAKSEPRHGAKKVSKSGNASDVLERHKKR
Protein: Malate dehydrogenase (EC 1.1.1.37) (C9JF79)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRRCSYFPKDVTVFDKDDKSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQG
Protein: Flavin-containing monooxygenase 1 (EC 1.14.13.148) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 1) (Dimethylaniline oxidase 1) (Hepatic flavin-containing monooxygenase 1) (FMO 1) (Trimethylamine monooxygenase) (P50285)
Organism: Mus musculus (Mouse)
Function: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P36365}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MVKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEGRASLYKSVVSNSSREMSCYPDFPFPEDYPNFVPNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDFAVSGQWEVVTVTNGKQNSAIFDAVMVCTGFLTNPHLPLDSFPGILTFKGEYFHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVFDSGYPWDMIFMTRFQNMLRNLLPTPIVSWLISKKMNSWFNHVNYGVAPEDRTQLREPVLNDELPGRIITGKVFIKPSIKEVKENSVVFNNTPKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMVPTGETQARWVVQVLKGATTLPPPSVMMEEVNERKKNKHSGFGLCYCKALQTDYITYIDDLLTSINAKPDLRAMLLTDPRLALSIFFGPCTPYHFRLTGPGKWEGARKAILTQWDRTVKVTKTRTIQESPSSFETLLKLFSFLALLIAVFLIFL
Protein: LIM/homeobox protein Lhx3 (LIM homeobox protein 3) (Homeobox protein LIM-3) (Homeobox protein P-LIM) (O97581)
Organism: Sus scrofa (Pig)
Function: Transcription factor. Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2 (By similarity). Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1. Required for the establishment of the specialized cells of the pituitary gland and the nervous system (By similarity). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Insulin gene enhancer protein ISL-1
- LIM domain binding 1
- ISL LIM homeobox 2.
Sequence:
WEGRPQELGGKEIPLCAGCDQHILDRFILKALDRHWHSKCLKCSDCHTPLAERCFSRGESLYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRARGGSKSDKDSVQEEGQDSDAEVSFTDEPSMAEMGPANGLYGGLGEPAPALGRPSGAPGSFPLEHGGLAGPEQYGELRPSSPYGVPSSPAALQSLPGPQPLLSSLVYPEAGLGLVPAGPPGGPPPMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF
Protein: Uncharacterized protein (Q384P0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MESPINPEIWKFLFRGGVAALSFASLFSLYHERYDLLSSLDADFKAISTAQTGCESETAIAKIVSKIKEESAQKKGMTRLSAERHGSTLVRLAALQKDGSNATVVRAAIKALVVIFGADAAGHRKLYMLGGYRTLLTTLSEAHRQGLQPLLEETAEVLHTLTRVDDSEVILDTDVPVGSEGAYALARIPATVKMLRVLNPQSSIVLLSSLTGIFANVCALRAGAVVIGRGLDGHSGISYFLRLLEHNNQGVAEHCIMTIRYLARSGIGHAELAEEENLCRLAENFSATSDPRIINSVLSILLVMFDSKEGPKFFHNVAEKTDIISTMFEIWCRASDKVLRDRAEVLVQLLSHVPQCTSKVQRYLERYRSQIAERRMADEEARRKQLQQMRQNQMMQQMMLENMGMGGGMDLAAMMGGGM
Protein: Ubiquitin-ribosomal protein eL40 fusion protein (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (CEP52)] (P62984)
Organism: Mus musculus (Mouse)
Function: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
Subcellular location: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: [Large ribosomal subunit protein eL40]: Cytoplasm {ECO:0000269|PubMed:36517592}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Ubiquitin-ribosomal protein eS31 fusion protein
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein eS1
- Polyubiquitin-B
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS2
Sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLRQLAQKYNCDKMICRKCYARLHPRAVNCRKKKCGHTNNLRPKKKVK
Protein: RRM domain-containing protein (D5MCQ6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MNASSAPQQQQQQQQPQQGQAPQQQQQGPPQHQYQQQRPFHGRVQNHMRGSGPFGNSNGYGRYTAPRGDQQHHDSTPLSSVSSRRVPLPPTSQHRASSNFNTTPSSTNLYIRGLMPNTNDDLLREMCSKYGNIASTKAIMDKATNNCKGYGFVDFESPQAAAAAVDGLNTEGVQAQMAKLQQQEQDPTNLYIANLPLDFTEQMLETELNKFGMVISTRILRTPDNQSRGVGFARMDSKEKCEVIISALNGGRFDTMSKEGPALLIKQADTGRKSKHSMNNPEMLQRMQYPQVYQSYYGYHPAAVYQQHYDVNSLASQMGGMHVGGGNPQANGGGDMYGAHMYGQNAGGQGGQGVGQGGQVFPADESTINGQDNVFTPLLLSSLNLFSLSILSNQSSLQKKTQCAAARAAINTHVHIVSPLPDPQNLLLFLNPKTIVPF
Protein: Sm-like protein LSM7 (AtLSM7) (Protein EMBRYO DEFECTIVE 2816) (U6 snRNA-associated Sm-like protein LSM7) (Q9SI54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of LSM protein complexes, which are involved in RNA processing. Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by promoting decapping and leading to accurate 5'-3' mRNA decay. The cytoplasmic LSM1-LSM7 complex regulates developmental gene expression by the decapping of specific development-related transcripts. Component of the nuclear LSM2-LSM8 complex which is involved splicing nuclear mRNAs. LSM2-LSM8 binds directly to the U6 small nuclear RNAs (snRNAs) and is essential for accurate splicing of selected development-related mRNAs through the stabilization of the spliceosomal U6 snRNA. Plays a critical role in the regulation of development-related gene expression.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23221597}. Nucleus {ECO:0000269|PubMed:23221597}.
Interaction partners:
- Sm-like protein LSM8
- Sm-like protein LSM3B
- Sm-like protein LSM5
- Sm-like protein LSM2
- Sm-like protein LSM4
- Sm-like protein LSM36B
- Sm-like protein LSM3A
- Sm-like protein LSM6A
- Sm-like protein LSM1A
- Small nuclear ribonucleoprotein SmD3a
Sequence:
MSGRKETVLDLAKFVDKGVQVKLTGGRQVTGTLKGYDQLLNLVLDEAVEFVRDHDDPLKTTDQTRRLGLIVCRGTAVMLVSPTDGTEEIANPFVTAEAV