wanglab/gogpt-training-data huggingface dataset:
Protein: ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) (Q9H611)
Organism: Homo sapiens (Human)
Function: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721}.; SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:23275553}.
Interaction partners:
- DNA replication ATP-dependent helicase/nuclease DNA2
- Origin recognition complex subunit 5
- DNA repair protein RAD52 homolog
- Proliferating cell nuclear antigen
- Telomerase reverse transcriptase
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- Uncharacterized protein
- Salivary acidic proline-rich phosphoprotein 1/2
- DNA repair protein RAD51 homolog 1
- ATP-dependent DNA helicase Q4
Sequence:
MLSGIEAAAGEYEDSELRCRVAVEELSPGGQPRRRQALRTAELSLGRNERRELMLRLQAPGPAGRPRCFPLRAARLFTRFAEAGRSTLRLPAHDTPGAGAVQLLLSDCPPDRLRRFLRTLRLKLAAAPGPGPASARAQLLGPRPRDFVTISPVQPEERRLRAATRVPDTTLVKRPVEPQAGAEPSTEAPRWPLPVKRLSLPSTKPQLSEEQAAVLRAVLKGQSIFFTGSAGTGKSYLLKRILGSLPPTGTVATASTGVAACHIGGTTLHAFAGIGSGQAPLAQCVALAQRPGVRQGWLNCQRLVIDEISMVEADLFDKLEAVARAVRQQNKPFGGIQLIICGDFLQLPPVTKGSQPPRFCFQSKSWKRCVPVTLELTKVWRQADQTFISLLQAVRLGRCSDEVTRQLQATASHKVGRDGIVATRLCTHQDDVALTNERRLQELPGKVHRFEAMDSNPELASTLDAQCPVSQLLQLKLGAQVMLVKNLSVSRGLVNGARGVVVGFEAEGRGLPQVRFLCGVTEVIHADRWTVQATGGQLLSRQQLPLQLAWAMSIHKSQGMTLDCVEISLGRVFASGQAYVALSRARSLQGLRVLDFDPMAVRCDPRVLHFYATLRRGRSLSLESPDDDEAASDQENMDPIL
Protein: Collagen alpha-1(XV) chain [Cleaved into: Restin (Endostatin-XV)] (O35206)
Organism: Mus musculus (Mouse)
Function: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Secreted {ECO:0000250|UniProtKB:P39059}.
Interaction partners:
- Collagen alpha-1
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-2
Sequence:
MTHRRTAQGRRPRWLLSIISALLSAVLQTRAATGSASQVHLDLTVLIGVPLPSSVSFTTGYGGFPAYSFGPGANVGRPARTLIPPTFFRDFAIGVAVKPNSAQGGVLFAITDAFQKVIYLGLRLSSVEDGRQRVILYYTEPGSHVSREAAVFSVPVMTNRWNRFAVTVQGEEVALFMDCEEQSQVRFQRSSWPLTFEPSAGIFVGNAGAMGLERFTGSIQQLTIYSDPRTPEELCEAQESSASGEASGFQEMDEVAEIMEAVTYTQAPPKESHVDPISVPPTSSSPAEDSELSGEPVPEGTPETNLSIIGHSSPEQGSGEILNDTLEVHAMDGDPGTDDGSGDGALLNVTDGQGLSATATGEASVPVTTVLEAENGSMPTGSPTLAMFTQSIREVDTPDPENLTTTASGDGEVPTSTDGDTEADSSPTGGPTLKPREEATLGSHGEEWLTPAVSKMPLKAFEEEEASGTAIDSLDVIFTPTVVLEQVSRRPTDIQATFTPTVVLEETSGAPTDTQDALTPTVAPEQMFTAEPTDGGDLVASTEEAEEEGSGSMPPSGPPLPTPTVTPKRQVTLVGVEAEGSGPVGGLDEGSGSGDIVGNEDLLRGPPGPPGPPGSPGIPGKPGTDVFMGPPGSPGEDGAPGEPGPQGPEGQPGLDGASGQQGMKGEKGARGPNGSAGEKGDPGNRGLPGPPGKNGEVGTPGVMGPPGPPGPPGPPGPGCTTELGFEIEGSGDVRLLSKPTISGPTSPSGPKGEKGEQGAKGERGADGTSTMGPPGPRGPPGHVEVLSSSLINITNGSMNFSDIPELMGPPGPDGVPGLPGFPGPRGPKGDTGVPGFPGLKGEQGEKGEPGAILTGDVPLEMMKGRKGEPGIHGAPGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGAKGDRGVTLPGPPGLPGPPGPPGPPGAVVNIKGAVFPIPARPHCKTPVGTAHPGDPELVTFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPVDPAYLRHFLNSLKGENEDASFRGESSNNLFVSGPPGLPGYPGLVGQKGEAVVGPQGPPGIPGLPGPPGFGRPGVPGPPGPPGPPGPPAILGAAVALPGPPGPPGQPGLPGSRNLVTALSDMGDMLQKAHLVIEGTFIYLRDSGEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSNPYQPQPPLNPILSANYERPVLHLVALNTPVAGDIRADFQCFQQARAAGLLSTFRAFLSSHLQDLSTVVRKAERFGLPIVNLKGQVLFNNWDSIFSGDGGQFNTHIPIYSFDGRDVMTDPSWPQKVVWHGSNPHGVRLVDKYCEAWRTTDMAVTGFASPLSTGKILDQKAYSCANRLIVLCIENSFMTDTRK
Protein: Hydrogenase 1 maturation protease (EC 3.4.23.-) (P19930)
Organism: Escherichia coli (strain K12)
Function: Protease involved in the C-terminal processing of HyaB, the large subunit of hydrogenase 1.
Interaction partners:
- Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit
- Hydrogenase-1 small chain
- Hydrogenase-1 operon protein HyaE
- Hydrogenase-1 large chain
- Hydrogenase-1 operon protein HyaF
- Hydrogenase-2 large chain
- Cytochrome bd-II ubiquinol oxidase subunit 2
- Cytochrome bd-II ubiquinol oxidase subunit 1
- Hydrogenase-2 small chain
- Isoleucine--tRNA ligase
Sequence:
MSEQRVVVMGLGNLLWADEGFGVRVAERLYAHYHWPEYVEIVDGGTQGLNLLGYVESASHLLILDAIDYGLEPGTLRTYAGERIPAYLSAKKMSLHQNSFSEVLALADIRGHLPAHIALVGLQPAMLDDYGGSLSELAREQLPAAEQAALAQLAAWGIVPQPANESRCLNYDCLSMENYEGVRLRQYRMTQEEQG
Protein: Probable E3 ubiquitin protein ligase DRIPH (EC 2.3.2.27) (DREB2A-interacting protein homolog) (RING-type E3 ubiquitin transferase DRIPH) (Q9LS86)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative E3 ubiquitin-protein ligase RING1b
- Putative E3 ubiquitin-protein ligase RING1a
- Uncharacterized protein
- F-box/kelch-repeat protein At5g03020
- Alpha/beta-Hydrolases superfamily protein
- Coatomer subunit zeta-1
- Uncharacterized protein
- Uncharacterized protein
- Transport/golgi organization-like protein, putative
- Duplicated homeodomain-like superfamily protein
Sequence:
MLTKVLSKEVKPCLACPICTNPFKDATTISECLHTFCRSCIRNKFINERVNACPVCNVNLGVFPLEKLRSDCTWQDLKLKIYRAMMESLKKAGPKTVAASVKSSKKKRKSRTSLRVSSSRVSSSPDTPLEPANVVVEPPNVVVEEKHRETVLALQSTRKPIITFQKRGRKASLPKKIDSKPEPELPPKEPKIKNLFDLNNEPEDNGLDEAEGSTFQEVVPKEKDLCKPIFSLSVTLNINDTPPDIVEPEISSDDDTEESVEPIQNKCVVNRETKEVPVQVNQNSLLISSDRDREDNSGQKLKTNGAATSRSRKKKGKKPVEKSYSLRPRIGRRTVNPAAGTTTPEAPVSVEEEMKVEEGRNNNPVWFSLKPSKTQNIEMLLPPITACCIRVKDSNMTVSYLKKYLMVKLGLESEDQVEIWLRDEPVCSSLTLHNLVDWWVQTTPLPERQSAMVGSSAAEFIMDLYYSFKSDASDSGSASE
Protein: CTCF (Q8TA44)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPRRTKKDEDPEDLQTFLNNFHKEIEGNSDEKVVNTILEAISAEAIDLDENGAEAGGSKPMEEAEADLDHAEEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQAAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPITCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGYLMRHMETHDDSANAREKRRRLKLGRNVRLQKDGTVITLIKDQYVDMDRDQEENEEDDNPESYDLAEIEPENSEAEDADDDVETIVSDPIRQRIKPAPIIINKQARLAASEKQPMIINQRLRSQRGTKTFHIKEEPDNSDFTVEWQGDDGEVMVVELVNGDEEVLVKHEPSANSKISAKNCFGFEDDDDYEEYGDGENEVDGASQEFLQLMDMIEQDS
Protein: ADP-ribosylation factor-like protein 6 (A1ZBK9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- non-specific serine/threonine protein kinase
Sequence:
MGMLHNLADLIKIKKDKMTILVLGLNNSGKSSIINHFKKSSEQTSIVVPTVGFMVEQFYIGMSGVSIKAIDMSGATRYRNLWEHQFKNCHGIIYVIDSSDRMRFVVVKDELDLVLQHPDLCNRIVPILFYGNKMDMEDSLSSVKIAAALRLENIKDKPWHICSSSAISGEGLGEGVQWLIQQMRFAMLNNKNAAKSRSKHSK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0S2Z4D1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQQ
Protein: Nup98 (A1YK24)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000256|ARBA:ARBA00004567}.
Interaction partners:
Sequence:
KLSSEADATRATNPAAQQAVLDLTSNQYKISTSNNPAPMKVKALGSTLNRKSLFDGLEEFDASVEGFNLKPSAKRLVIKPKVKSVEGGNPSSSIGSAPNTPQSRPKGATPNKERESFSGAIPSEPLPPAGNSPGATNGRESQDNGRRESWLHPNNLEKVRQHNIQTGMDQGSPHNSTLNELVPRKPLDTYRPSSTVRLSVSTIPENPFEDQSSTIARRETFTSQQANESVLSNRSNEAEDSAANRSRLAIEAAAAEAADDESHPTGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRVKHF
Protein: Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114) (Q38DV8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|HAMAP-Rule:MF_03190}; Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_03190}; Matrix side {ECO:0000256|HAMAP-Rule:MF_03190}.
Interaction partners:
- Monooxygenase, putative
- 5-demethoxyubiquinone hydroxylase, mitochondrial
- Ribose 5-phosphate isomerase, putative
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
Sequence:
MSSAMARGVSAAEISKFSRLQKYWWCPQGPLRTLHQFNPVRVEFINKACRCAFTPSDLAATAGIRPGMSVLDVGCGGGILSESIARLGGDVLGIDMCKESIAVAEERRQRVLRDITPQASLAYRCVPLHEVVEGEGRQFELVVASEVIEHVSDAAAFLHDICAATKPGGVLVISTMDKSLFTALSFIVVAEHITGIVEPGTHDWAKFIPPADLSRCALNHGVSQIEMRHIVACPDVLKTFASRQLHLSFRLSSRLYTGHYIWAGVKRSTAASAASNIGSNMKSEKDAK
Protein: peptidylprolyl isomerase (EC 5.2.1.8) (Q581Y2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase
- Nucleolar GTP-binding protein 1
Sequence:
MLKSPQNFRKCGLLFVSTFDFLYACNLFPPVLFSSGKESMPKVSVPPKTERHGKIEAPETNNPKVFFDVSINEKAAGRIVMELYADTVPRTAENFRALCTGEKGRGKSGKPLHYKGCIFHRVIPGFMLQGGDITRGNGTGGESIYGTTFRDESFAGKAGKHTGLGCLSMANAGPNTNGSQFFICTANTPWLNGKHVVFGRVTEGIDVVKSIERLGSDSGKTRGRIIIANCGELQTQKEGAAKKEKVKAKEGNNAGKLSTIVEGTGGAKRPREDVEDLEERKKRIREKRERIAKLRAQAEEK
Protein: Polyadenylate-binding protein (PABP) (Q91YZ8)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU362004}.
Interaction partners:
Sequence:
MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVMKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDGNLKELFSQFGKTLSVKVMRDSSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKAIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRREFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPASAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSALRQSGPRPALRHLAPTGVPTAVPNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGTVAAATS
Protein: Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3) (Q9WUB4)
Organism: Mus musculus (Mouse)
Function: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:D0G6S1}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:O00399}.
Interaction partners:
- Dynactin subunit 2
- Dynactin subunit 4
- Dynactin subunit 5
- Actin-related protein 10
- Dynactin subunit 3
- Alpha-centractin
- Dynactin subunit 1
- Beta-centractin
- Cytoplasmic dynein 1 light intermediate chain 2
- F-actin-capping protein subunit beta
Sequence:
MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIIIGEGNLIEEQALIINAHPDNIIPDTEDTEPKPMIIGTNNVFEVGCHSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCSLNTFEAIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN
Protein: Microsomal glutathione S-transferase 2 (Microsomal GST-2) (EC 2.5.1.18) (Glutathione peroxidase MGST2) (EC 1.11.1.-) (Leukotriene C4 synthase MGST2) (EC 4.4.1.20) (Microsomal glutathione S-transferase II) (Microsomal GST-II) (Q99735)
Organism: Homo sapiens (Human)
Function: Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:8703034}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:8703034}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Microsomal glutathione S-transferase 1
- Epoxide hydrolase 1
- Glutathione reductase, mitochondrial
- Glutathione synthetase
- Cytochrome P450 1B1
- Cytochrome P450 3A4)
- Cytochrome P450 1A1
- Cytochrome P450 1A2
- Phospholipid hydroperoxide glutathione peroxidase GPX4
- Peroxiredoxin-6
Sequence:
MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKKLRRQF
Protein: Solute carrier family 22 member 13 (Organic anion transporter 10) (OAT10) (Organic cation transporter-like 3) (ORCTL-3) (ORCTL3) (Q9Y226)
Organism: Homo sapiens (Human)
Function: Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions. Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption. Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption. Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate. Urate and orotate transports are Cl(-)-dependent. Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:18411268, ECO:0000269|PubMed:31780526, ECO:0000269|PubMed:35144162, ECO:0000269|PubMed:35462902}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Xylulose kinase
- Solute carrier family 2, facilitated glucose transporter member 9
- Serine/threonine-protein kinase OSR1
- Sodium-dependent phosphate transport protein 4
- Sodium-dependent phosphate transport protein 1
Sequence:
MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSSPGVAFVSSTYF
Protein: Protein phosphatase Mg2+/Mn2+ dependent 1D isoform 1 (A0A0S2Z4M2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC
Protein: Bitesize isoform 3 (Q6XK18)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MINKDNESAAGDYEMANSSSNFSNIRHKDPTSSNNSHTVGQNFASDSFRAMEPTELVSSDREAYSVDSLNEPPAVPELSVEDGLADDDSWVEELSQRGEDEDEDLSNATTTPTATDSEDAEGEGEGARRHGYMDREEDLRGYNRSAIDFTLHTIVEESCEESEVASMRADNEDVELEDEDLSERRRQRTLQHHHRLSASELEKYFFFGLGDGRVMSSIDTRGDDTASEVSSECSESLDSLPHEDQLLDTSGASDLASSRLEKYFLSGFMGFSGAEKQAESDESGGSVGSDSEGQPSPSQRRKRLVRARGTPRSHNSSLDNLLLPESDTLDATVTSAGGAAAATVEDTSESEAGCDDTVIHLANAGASDGSSSDTIKRKKQLRKRHESLDEKKLHDLEPSECRTPTPGSSGQVQMQSQAKKQQQQHHHSRDSGFVGSNDDLLKAAPDCEPPKSPTPALEQISEDREPVHSQISLARMDQPSTSAAAAVASTLSSQLKNLALPNLVRKDSFNNWSSDEETNLMMSKMRQFFKNLIVATANAQQSKPSTPNQGPSTTNVNTTPSSQRRLAKSRPAQLAYFENELTRLMKTVPGINDEQVREIVEYLSSEDTWSDSYDSSDYTSSDLEGGERKGQLKAQISASCQQIINKFEIDEEGDRGDGGLLDESQSVPMEALVYQKLVASFSKVAAGGEPETEATKAVEEAEPSTERSPQLFAKVMQHIGTRLVALMHEVSSGNETPTPSPQGQRHHRRLQAKISATTTEDEEDEVAEQLKAMPIKQLKLRSKSHDLLLDGTTPHSHHLHHHATVHYPAGGVGSGAGGSGGPGHSDNAGEECGVTSDYERFSWRGSFESALLANGDSRTRLSQLSQLDRDNSSSASALAVAKRRSAGDLLFSQHQQSLSREQLDRVRSCGSIGGGDAHHHQLESSPAKPWLSSAGSSIGGDSTKDVRRSSVPDAIYETDSSDEAASHQFGGARSTLPRSLNPNQVVASTNSLPRLPTTGVGAPITSTPKTKSQSALNHTPSNLSTVSATGSAKSARYRSPGLAARAAAVSGAGGGSSGGVGVGASSGSTGKKLGAGFQFLYSKRDARKRLNMSAEEAKVAAEELSRSPVIGQRQADGSGSPIQSRASSETWPTQSDEDIDRLVAMHQNRSSXSSLGVRSEXMASVYXXXGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLFDNPQSQWYLLQERSEPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEGSLVLRSSLDGIRANLP
Protein: Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) (Q8IWE5)
Organism: Homo sapiens (Human)
Function: Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15905402}. Lysosome membrane {ECO:0000269|PubMed:22172677}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:22172677}.
Interaction partners:
- ADP-ribosylation factor-like protein 5B
- Ras-related protein Rab-9A
- Ras-related protein Rab-9B
- ADP-ribosylation factor-like protein 8B
- Kinesin light chain 1
- Kinesin-1 heavy chain
- Kinesin light chain 2
- Kinesin light chain 4
- Beta-alanine-activating enzyme
- Kinesin light chain 3
Sequence:
MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
Protein: von Willebrand factor C domain-containing protein 2-like (VWC2-like protein) (Brorin-like) (B2RUY7)
Organism: Homo sapiens (Human)
Function: May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.
Subcellular location: Secreted {ECO:0000250}. Synapse {ECO:0000250}.
Interaction partners:
Sequence:
MALHIHEACILLLVIPGLVTSAAISHEDYPADEGDQISSNDNLIFDDYRGKGCVDDSGFVYKLGERFFPGHSNCPCVCALDGPVCDQPECPKIHPKCTKVEHNGCCPECKEVKNFCEYHGKNYKILEEFKPSPCEWCRCEPSNEVHCVVADCAVPECVNPVYEPEQCCPVCKNGPNCFAGTTIIPAGIEVKVDECNICHCHNGDWWKPAQCSKRECQGKQTV
Protein: Alpha/beta-Hydrolases superfamily protein (At5g11650) (Lysophospholipase-like protein) (Q9LYG5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Methionine aminopeptidase 1D, chloroplastic/mitochondrial
- Protein HIGH CHLOROPHYLL FLUORESCENCE PHENOTYPE 173
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- Pheophytinase, chloroplastic
Sequence:
MASTSAEMDQLTSGASNRIIFILRTLRKCLVFVLSLVLSLLLILRLRPRRRVSPLSSPEDEAVPAPSRRWRRKMAWKLEEEDTARRRSLAEGVEMAGDGEISCSLFYGRRGNALFSRSWLPISGELRGILIIIHGLNEHSGRYSQFAKQLNASNLGVYAMDWIGHGGSDGLHGYVPSLDYVVSDTEAFLEKIRSENPGVPCFLFGHSTGGAVVLKAASSPSIEDMLAGIVLTSPALRVKPAHPIVGAIAPIFSLLAPRFQFKGANKRGIPVSRDPEALLAKYSDPLVYTGPIRVRTGYEILRITAYLTRNFKSVTVPFFVLHGTEDKVTDPLASQDLYNQAPSVFKDIKLYDGFLHDLLFEPEREEVGRDIIDWMMNRLDDVNGSAASLW
Protein: Complement C1q subcomponent subunit A (P98086)
Organism: Mus musculus (Mouse)
Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Subcellular location: Secreted.
Interaction partners:
- Complement C1q subcomponent subunit B
- Complement C1q subcomponent subunit C
- Complement C1r-A subcomponent
- Complement C1s-1 subcomponent
- Complement C4-B
- Complement C1s-1 subcomponent
- Complement C1r-B subcomponent
- Plasma protease C1 inhibitor
- Complement C2
- Calreticulin
Sequence:
METSQGWLVACVLTMTLVWTVAEDVCRAPNGKDGAPGNPGRPGRPGLKGERGEPGAAGIRTGIRGFKGDPGESGPPGKPGNVGLPGPSGPLGDSGPQGLKGVKGNPGNIRDQPRPAFSAIRQNPMTLGNVVIFDKVLTNQESPYQNHTGRFICAVPGFYYFNFQVISKWDLCLFIKSSSGGQPRDSLSFSNTNNKGLFQVLAGGTVLQLRRGDEVWIEKDPAKGRIYQGTEADSIFSGFLIFPSA
Protein: Enkurin domain-containing protein (Q38FI9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Protein artemis
- Polynucleotide kinase 3'-phosphatase, putative
- Flap endonuclease 1
Sequence:
MPTGAARLNFLQIKEQQQLNRERLREAAVEEQRAKEALCRQKEQYSHVQSHGYGRVVGKPASDVQIKVYIRECDGERAQCHTFMESEAMRHNASCKQEGKPRPAQPPRQKVQKLPPVAAPPQKKQEHTQQQQQRLSGPANASDTQRGIVPKYLLQRKAELAAQKEATQREAERQREIARYPPGHRLVSEEERKETLEKLAARRRELEMELHKIPIRYDTQSIKERRSKIENELSEIEAAERKFGSAKELFVPI