wanglab/gogpt-training-data huggingface dataset:
Protein: Peroxidase 2 (EC 1.11.1.7) (ATP12a) (Atperox P2) (Q67Z07)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular location: Secreted {ECO:0000255|PROSITE-ProRule:PRU00297}.
Interaction partners:
- Pollen Ole e 1 allergen and extensin family protein
- Plant viral-response family protein
- Protein SEED AND ROOT HAIR PROTECTIVE PROTEIN
- Probable pectinesterase/pectinesterase inhibitor 46
Sequence:
MAIKNILALVVLLSVVGVSVAIPQLLDLDYYRSKCPKAEEIVRGVTVQYVSRQKTLAAKLLRMHFHDCFVRGCDGSVLLKSAKNDAERDAVPNLTLKGYEVVDAAKTALERKCPNLISCADVLALVARDAVAVIGGPWWPVPLGRRDGRISKLNDALLNLPSPFADIKTLKKNFANKGLNAKDLVVLSGGHTIGISSCALVNSRLYNFTGKGDSDPSMNPSYVRELKRKCPPTDFRTSLNMDPGSALTFDTHYFKVVAQKKGLFTSDSTLLDDIETKNYVQTQAILPPVFSSFNKDFSDSMVKLGFVQILTGKNGEIRKRCAFPN
Protein: Centrosomal protein of 68 kDa (Cep68) (Q76N32)
Organism: Homo sapiens (Human)
Function: Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:31974111}. Note=Localizes to thin fibers protruding away from the proximal ends of the two centrioles. Dissociates from interphase centrosomes at the onset of mitosis. {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143}.
Interaction partners:
Sequence:
MALGEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGAEGIPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRGAKDRLTIGKHLDMGSPQLRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDDEYLALPARLTQVSSLVSYLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPGAALQGSGDPEGQNPCFLRSFVRAHDSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRWPFSDPDVEGQLPRKGGEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTSLKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQCLLENTPVLEDVLGRIAKQSGELESHADRLYDSILASLDMLAGCTLIPDKKPMAAMEHPCEGV
Protein: Putrescine N-methyltransferase 2 (NaPMT2) (EC 2.1.1.53) (Q93XQ4)
Organism: Nicotiana attenuata (Coyote tobacco)
Function: Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (By similarity). Methyltransferase that mediates the conversion of putrescine to N-methylputrescine (By similarity).
Interaction partners:
Sequence:
MEVISTNTNGSTIFKNGAIPMNGHQNGTSKHQNGTSEHPNGHQNGTSEHQNGHQNGTSEQQNGTISHDNGNKLVGNSNCIKPGWFSEFSALWPGEAFSLKVEKLLFQGKSDYQDVMLFESATYGKVLTLDGAIQHTENGGFPYTEMIVHLPLGSIPNPKKVLIIGGGIGFTLFEMLRYPSIEKIDIVEIDDVVVDVSRKFFPYLAANFNDPRVTLVLGDGAAFVKAAQAEYYDAIIVDSSDPIGPAKDLFERPFFEAVAKALRPGGVVCTQAESIWLHMHIIKQIIANCRQVFKGSVNYAWTTVPTYPTGVIGYMLCSTEGPEVDFKNPVNPIDKETTQVKPKLAPLKFYNSDIHKAAFILPSFARSMIES
Protein: Heat shock transcriptional regulator (Q0P926)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Interaction partners:
- Curved-DNA binding protein
- Chaperone protein DnaJ
- RNA polymerase sigma factor SigA
- DnaJ-like protein
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta
- Glutathione-regulated potassium-efflux system protein
- DNA-directed RNA polymerase subunit omega
- DNA-directed RNA polymerase subunit beta'
- Heat-inducible transcription repressor HrcA
Sequence:
MEQHYDEPVYLISVVAKVLSIHPQTLRQYEREGLIEPSRTDGKIRLYSQRDIDRIKLILRLTRDMGINLAGVDVILKLKNQLHEFENLIDELRLELSKQQDKEAASKAVVKHKNSFDLIFYEKK
Protein: Outer-membrane lipoprotein carrier protein (P20) (P61316)
Organism: Escherichia coli (strain K12)
Function: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane); the inner membrane retention signal functions at the release step.
Subcellular location: Periplasm.
Interaction partners:
- Lipoprotein-releasing system transmembrane protein LolC
- Lipoprotein-releasing system transmembrane protein LolE
- Lipoprotein-releasing system ATP-binding protein LolD
- Outer-membrane lipoprotein LolB
- Major outer membrane lipoprotein Lpp
- Replication-associated recombination protein A
- LPS-assembly protein LptD
- Peptidoglycan-associated lipoprotein
- DNA translocase FtsK
- Outer membrane protein assembly factor BamA
Sequence:
MKKIAITCALLSSLVASSVWADAASDLKSRLDKVSSFHASFTQKVTDGSGAAVQEGQGDLWVKRPNLFNWHMTQPDESILVSDGKTLWFYNPFVEQATATWLKDATGNTPFMLIARNQSSDWQQYNIKQNGDDFVLTPKASNGNLKQFTINVGRDGTIHQFSAVEQDDQRSSYQLKSQQNGAVDAAKFTFTPPQGVTVDDQRK
Protein: Tumor protein D53 homolog (Tumor protein D52-like 1) (Q9I8F4)
Organism: Gallus gallus (Chicken)
Interaction partners:
- RBR-type E3 ubiquitin transferase.
- Tumor protein D52
- Nuclear receptor coactivator 7
- Iron-sulfur cluster co-chaperone protein HscB
Sequence:
MERQARGLLETQSLHEADEDMVTDVDFTSMISEEEKEELKAELAKLEDEISTLRQVLAAKEKHLIEIKQKLGMSLMNELKQNFSKSWHDMQTTSAYKKTHETLSHAGQKATAAISNVGTAISKKFGDMRSHSISYSIRHSISMPAMRNSPTFKSFEEKVETTVTSLKTKVGGTSHTGGSFEEVLSSTAHASAQSSLAGTRLPESEEELQC
Protein: Myocyte enhancer factor 2D MEF2D (Myocyte-specific enhancer factor 2D) (Q98870)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDMDKVLLKYTEYNEPHESRTNADIIEALNKKEHRDSESPDPEEPFSLTPRTEEKYKKIDEEFDKMMQSYRLSSTVPAPTFSMPVTVPVSNQSPLPFSNPSSLVTTSFVTSTLTDPRLLSPQQPQLQRNTVSPGLPQRPASAGALLGGDLNNSNGACPSPVANGYVSARASPGLLSVSNGNSMGKVVQAKSPPPPSTQMANSRKPDLRVITSQSSKGLMQLTDEELELVSENAQRLGTSQVTQPLTTPVVSVATPSLLTPFSMPTAYNTEYQLTSADLTALQAFTPSGALLPGNMTTWQQQQQPSVSQQPQQQPSVSQQQTQQQQQQQQQPQQLTLASLSNLVPVGTIPHGATLTVNTNPSISIKSEPVSPNRDRSTPSSTPGAVGGVSGLTVSQYPGTLRLEPTGRSPVDSISSNGSSYEGSDRDDSGQPRPPDFSSLGLLRATGDQPAQAEQQESANVKRMRLDTWVT
Protein: LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1) (O55203)
Organism: Mus musculus (Mouse)
Function: Transcription cofactor. Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.
Subcellular location: Nucleus {ECO:0000305}. Note=Colocalizes with SLK at leading edges (PubMed:19675209). {ECO:0000269|PubMed:19675209}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000305|PubMed:9192866}.
Interaction partners:
- Single-stranded DNA-binding protein 2
- Rhombotin-2
- Insulin gene enhancer protein ISL-1
- Single-stranded DNA-binding protein 3
- LIM domain only protein 3
- LIM/homeobox protein Lhx2
- Rhombotin-1
- LIM/homeobox protein Lhx9
- Single stranded DNA binding protein 4
- LIM/homeobox protein Lhx3
Sequence:
MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCAMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNTTNSAGSKKKTPAASLSLATQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQETKSENAPPQASQ
Protein: Zinc finger and BTB domain-containing protein 42 (B2RXF5)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q811H0}. Nucleus {ECO:0000269|PubMed:21193930}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q811H0}. Note=In skeletal myofibers, highly enriched in subsynaptic nuclei at the neuromuscular junctions. {ECO:0000250|UniProtKB:Q811H0}.
Interaction partners:
Sequence:
MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGSRDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQEKDRSLDPGNPAPGAEPAQPPCPWPVWTADLCPAARKAKLPPFGVKAALPPRASGPPPCQVPEESDQALDLSLKSGPRQERVHPPCVLQTPLCSQRQPGAQPLVKDERDSLSEQEESSSSRSPHSPPKPPPVPAAKGLVVGLQPLPLSGEGSRELELGAGRLASEDELGPGGPLCICPLCSKLFPSSHVLQLHLSAHFRERDSTRARLSPDGVAPTCPLCGKTFSCTYTLKRHERTHSGEKPYTCVQCGKSFQYSHNLSRHTVVHTREKPHACRWCERRFTQSGDLYRHVRKFHCGLVKSLLV
Protein: Ras-related protein Rab-5A (EC 3.6.5.2) (P20339)
Organism: Homo sapiens (Human)
Function: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:23815289}; Lipid-anchor {ECO:0000305|PubMed:7991565}; Cytoplasmic side {ECO:0000269|PubMed:23382462}. Early endosome membrane {ECO:0000269|PubMed:23815289, ECO:0000269|PubMed:25869668}; Lipid-anchor {ECO:0000305|PubMed:7991565}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasmic vesicle {ECO:0000269|PubMed:10818110}. Cell projection, ruffle {ECO:0000250|UniProtKB:P18066}. Membrane {ECO:0000269|PubMed:23815289}. Cytoplasm, cytosol {ECO:0000269|PubMed:23382462}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CQD1}. Endosome membrane {ECO:0000269|PubMed:22431521, ECO:0000269|PubMed:23382462}. Note=Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable). {ECO:0000269|PubMed:17081065, ECO:0000305}.
Interaction partners:
- Ras-related protein Rab-5B
- DCC-interacting protein 13-alpha
- Rab GTPase-binding effector protein 1
- Early endosome antigen 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Rabenosyn-5
- Rab5 GDP/GTP exchange factor
- Beclin-1
- Alsin
- Vacuolar protein sorting-associated protein 45
Sequence:
MASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPTQPTRNQCCSN
Protein: Glutamate--glyoxylate aminotransferase 2 (AtGGT2) (EC 2.6.1.4) (Alanine aminotransferase GGT2) (EC 2.6.1.2) (Alanine--glyoxylate aminotransferase GGT2) (EC 2.6.1.44) (Alanine-2-oxoglutarate aminotransferase 2) (EC 2.6.1.-) (Q9S7E9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the Glu:glyoxylate aminotransferase (GGT), Ala:glyoxylate aminotransferase (AGT), Ala:2-oxoglutarate aminotransferase (AKT) and Glu:pyruvate aminotransferase (GPT) reactions in peroxisomes.
Subcellular location: Peroxisome {ECO:0000269|PubMed:12529529}.
Interaction partners:
- Serine--glyoxylate aminotransferase
- Glycerate dehydrogenase HPR, peroxisomal
- Glycolate oxidase 2
- Glycolate oxidase 1
- Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial
- Alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial
- Glycolate oxidase 3
- Alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial
- Peroxisomal
- Glycine dehydrogenase
Sequence:
MSLKALDYESLNENVKNCQYAVRGELYLRASELQKEGKKIIFTNVGNPHALGQKPLTFPRQVVSLCQAPFLLDDPNVGMIFPADAIARAKHYLSLTSGGLGAYSDSRGLPGVRKEVAEFIERRDGYPSDPELIFLTDGASKGVMQILNCVIRGQKDGILVPVPQYPLYSATISLLGGTLVPYYLEESENWGLDVNNLRQSVAQARSQGITVRAMVIINPGNPTGQCLSEANIREILRFCCDERLVLLGDEVYQQNIYQDERPFISSKKVLMDMGAPISKEVQLISFHTVSKGYWGECGQRGGYFEMTNIPPRTVEEIYKVASIALSPNVSAQIFMGLMVSPPKPGDISYDQFVRESKGILESLRRRARMMTDGFNSCKNVVCNFTEGAMYSFPQIKLPSKAIQAAKQAGKVPDVFYCLKLLEATGISTVPGSGFGQKEGVFHLRTTILPAEEEMPEIMDSFKKFNDEFMSQYADNFGYSRM
Protein: Zinc finger CCCH domain-containing protein 6 (AtC3H6) (Q56XU4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Zinc finger CCCH domain-containing protein 44
- Zinc finger CCCH domain-containing protein 55
- Galactose oxidase/kelch repeat superfamily protein
- Putative zinc finger CCCH domain-containing protein 9
- Putative zinc finger CCCH domain-containing protein 10
- Zinc finger CCCH domain-containing protein 43
- Zinc finger CCCH domain-containing protein 51
- Zinc finger CCCH domain-containing protein 46
- Protein FRIGIDA-ESSENTIAL 1
- Zinc finger CCCH domain-containing protein 28
Sequence:
MRALHKRVSWPPDFKLCQVRLFISEDSPSQVGSESQDHLQAKSPLASHPSDDNLPPGFGGPFSANESQIKLSDIPLIKWKCSVQILLDREWKVVAGDESKEVEAQNERELRVLEAFYPGASSIPPNPSVPADVEDSHHDDQQTIVIPILPVEDDDIAMDSASDFPTQSGVDVGTEPSITDENTSTSSTLPAGPDIMAALSAISNSKEQGSMIDQDLLIKILSNPKLVENLVANRGSAGSVSSNTSSLYSSSTHEANGVVTTAPISSNGQFYAQPPITHIPPMAYTPHAPQDQPNYGAPPARDASYYKNLIQQHGGDRQETPPVQHLGYRYNLQPGGGPNPEMVNSSNNNQRPRDSKPKIMKACMYFNSARGCRHGANCMYQHDATPYQPRNLNNGNINTSDMQNAKRMRFDRD
Protein: Chaperone protein DNAJ, putative (Q389Z2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVSKKSLYDVLGLSRDATAADITRVYRRLALQYHPDRNPEGAAKFKEISNAYSVLSDEKDRRTYDATGIVPGAASGRGDEMSESQRSAEMQQRVHQFYATYAGSHEEEEDVIERFKKCKGNFGRMIREELLFDNGKVEEVKRLQDLVRSLVKRGSLESTEAWEITSTEAARKRIERAMAKERKRAVETLDAMGLSTKKSGAGSMQELQAIISRNQEKQWADMLGNLEEKYVKRKNVAEEHAGKKKKREQQESASAPRKKTKK
Protein: Disrupted underground network, isoform A (Disrupted underground network, isoform B) (MIP14022p) (Q0E8M3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Slow as molasses, isoform B
Sequence:
MSAFTCTQYLNLNSKDVSSMSTTVTLNAACFGRQDLNLFIESLETISRLERERHERRQLRREQRLHQARITELADERCSSPTPTAEEAVDEPLLYLEAKCIPYAVSGHIFAQGDNTPCPEYHMCDDEAYGSASYSARSSVTYCSCGGISNLDSDSGESEGKMKPFVHPSSQAKPKNRYSSTRSRIINLMLKRNRAKPALIEHLQRQGHGDTLSSENISHQFPRLTSSQKRSAEHSFLDKALRYLTL
Protein: Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15) (Q9H2Y9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Extracellular sulfatase Sulf-1
Sequence:
MDEGTGLQPGAGEQLEAPATAEAVQERCEPETLRSKSLPVLSSASCRPSLSPTSGDANPAFGCVDSSGHQELKQGPNPLAPSPSAPSTSAGLGDCNHRVDLSKTFSVSSALAMLQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQIQELNASAPNDGLCQGGNSTATLEPPACPKDSGGNNHWVYVALFICAQILIGMGSTPIYTLGPTYLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKKKFSVDAVSDDDVLKEKSNNSEQADKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTECTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRTCNTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWYSIKYKEDGLQRRRQREFPLSTVSERVGHPDNARTRSCPAFSTQGEFHEETGLQKGIQCAAQTYPGPFPEAISSSADPGLEESPAALEPPS
Protein: Myocardin (Q8IZQ8)
Organism: Homo sapiens (Human)
Function: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Serum response factor
- Transgelin
- Homeobox protein Nkx-2.5
- Heart- and neural crest derivatives-expressed protein 2
- Calponin-1
- Krueppel-like factor 4
- Myocardin-related transcription factor A
- Myosin-11
- Transcription factor GATA-4
- T-box transcription factor TBX5
Sequence:
MTLLGSEHSLLIRSKFRSVLQLRLQQRRTQEQLANQGIIPPLKRPAEFHEQRKHLDSDKAKNSLKRKARNRCNSADLVNMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVEKNILPVDSAVKEAIKGNQVSFSKSTDAFAFEEDSSSDGLSPDQTRSEDPQNSAGSPPDAKASDTPSTGSLGTNQDLASGSENDRNDSASQPSHQSDAGKQGLGPPSTPIAVHAAVKSKSLGDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLLQQQQLFLQLQILSQQQQQQQHRFSYLGMHQAQLKEPNEQMVRNPNSSSTPLSNTPLSPVKNSFSGQTGVSSFKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALMDRLRPFQDCSGNPVPNFGDITTVTFPVTPNTLPNYQSSSSTSALSNGFYHFGSTSSSPPISPASSDLSVAGSLPDTFNDASPSFGLHPSPVHVCTEESLMSSLNGGSVPSELDGLDSEKDKMLVEKQKVINELTWKLQQEQRQVEELRMQLQKQKRNNCSEKKPLPFLAASIKQEEAVSSCPFASQVPVKRQSSSSECHPPACEAAQLQPLGNAHCVESSDQTNVLSSTFLSPQCSPQHSPLGAVKSPQHISLPPSPNNPHFLPSSSGAQGEGHRVSSPISSQVCTAQMAGLHSSDKVGPKFSIPSPTFSKSSSAISEVTQPPSYEDAVKQQMTRSQQMDELLDVLIESGEMPADAREDHSCLQKVPKIPRSSRSPTAVLTKPSASFEQASSGSQIPFDPYATDSDEHLEVLLNSQSPLGKMSDVTLLKIGSEEPHFDGIMDGFSGKAAEDLFNAHEILPGPLSPMQTQFSPSSVDSNGLQLSFTESPWETMEWLDLTPPNSTPGFSALTTSSPSIFNIDFLDVTDLNLNSSMDLHLQQW
Protein: GATOR2 complex protein WDR59 (WD repeat-containing protein 59) (Q6PJI9)
Organism: Homo sapiens (Human)
Function: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:28199306}.
Interaction partners:
- GATOR1 complex protein NPRL2
- Nucleoporin SEH1
- GATOR2 complex protein MIOS
- GATOR1 complex protein DEPDC5
- GATOR1 complex protein NPRL3
- GATOR2 complex protein WDR24
- Protein SEC13 homolog
- KICSTOR complex protein SZT2
- KICSTOR complex protein ITFG2
- KICSTOR complex protein kaptin
Sequence:
MAARWSSENVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESISLLPEPEKTLHTEDTDHQHTASHGEEEALKEDPPRNLLEERKSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSNHRVKMLVKFPAQYPNNAAPSFQFINPTTITSTMKAKLLKILKDTALQKVKRGQSCLEPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRQIKAAGKVIIQDIACLLPVHKSLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGLPNPFGPFPNRSSNLVVSHSRYPSFTSSGSCSSMSDPGLNTGGWNIAGREAEHLSSPWGESSPEELRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF
Protein: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 7.1.1.2) (Q57VW8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU364066}; Peripheral membrane protein {ECO:0000256|RuleBase:RU364066}; Matrix side {ECO:0000256|RuleBase:RU364066}.
Interaction partners:
- Cytochrome c1, heme protein, mitochondrial
- NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial
- Acyl carrier protein
- Electron transfer protein, putative
- NADH-ubiquinone oxidoreductase, mitochondrial, putative
- Reiske iron-sulfur protein, mitochondrial
- Uncharacterized protein
- 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Mitochondrial carrier protein, putative
Sequence:
MLRRVGFLSATGSLLQAAASQPPPTQQEQRVHGGLKDQDRIFVNLYQDFGTDIDSAERRGDWYRTRDLLLKGHDWVINEIKASGLRGRGGAGFPSGLKWSFMPKSKPDGRPSYIVVNGDESEPGTCKDREIMRHEPHKLVEGALIAGFAMRARYGYIYIRGEFYNEWRAVDQAIKEAYARGYLGRNACGSGYDFDLYTYCGAGAYICGEETAMISSIEGGPGKPRLKPPFPANVGLYGCPTTVTNVETVSVSPTILRRGPSWFNSFGRRNNAGVKLFCICGHVNRPCTVEEEMSIPLRDLIERHAGGVRGGWDNLLAVIPGGSSCPLIPKSICDNVLMDFDALKEAQTGLGTAAVIVMDKSTDLIAAIHRLSMFYAHESCGQCTPCREGSPWLEKMMQRFVHGNARMEEVGTMLDVSKQLEGRTICALATAAAWPVQGLARHFTPLLQERIEKYWEANPHWGKSGSPWRRWKTHRYYAMQKGEKLNWDGKIVRNWN
Protein: Possible metal cation transporting P-type ATPase CtpH (P96271)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- UPF0039 protein Rv2851c
Sequence:
MPVRAVATGFRATATLTGASITAATAVSATLAKTGVGTGMKVAIIPLRAGAKALSGELSRETLGRNCWRGERRAWIEVRGLRSGGDDELGRVVLNAIQAHPGVGSASLNYPLSRVVVAIDDPDTSLRELCRIVDDAEKAERHRHPDQAADQLAQSPGSLPGDGVLLAVRAVTVAATAAGLGLALGGRALRWPRFPLVIEAAVAAVDHQPLLRRLLEDRIGTEATATVLELAMAAAHTVTLSPAALSVDLTIQALKAAECRAGARAWRRHEPQLALHADEPADQPQSLWPRPARSTQPVQRSVARFALIQALSAVLVGAGTRDADMAATATLVATPKASRTTPEAFAAALGQGLADQHAVLPLRPESLRRLDRVDAIVIDPRVLCTDDLRVARIRGCGADELSTAWNRAQLVLTESGLRPGWHRVPGVSASGSDSAVEALFRPMHDRLASAVVAEAHRTGADLVSVDVDALGELRPVFDDIRPLDDGASGSLDEALARAVAELRQAGRTVAVLSSVGKQALSAADVALGVLPPPGAGAPPWYADVLLPDLGAAWRVLHAIPAARAARQRGNEISGGASALGALLMLPGVRGLGPGPVTTGAAAGLLSGYLLARKVVDAQAPRPAPAHEWHAMSVEQVRKALPSPDEQAPAKAPPSPYPARALAGGLHTAKRGAQITQAPLNALWQLTKAMRAELSDPLTPMLALGAMASAVLGSPVDAVMVGSVLTGNSILAASQRLRAESRLNRLLAQQIPPARKVLAGADDQPRYIEVRAEELRPGDIIEVRTHEVVPADARVIEEVDVEVDESALTGESLSVTKQVEPTPGVDLIERRCMLYAGTTVVSGTAVAVVTAVGPDTQERRAAELVSGDLSSVGLQHQLSRLTNQAWPVSMTGGALVTGLGLLRRRGLRQAVASGIAVTVAAVPEGMPLVATLAQQASARRLSHFGALVRIPRSVEALGRVDMVCFDKTGTLSENRLRVAQVRPVAGHSREEVLRCAAHAAPASNGPQVHATDVAIVQAAAAAAASGTDGAEPGAAEPAAHLPFRSGRSFSASVSGTELTVKGAPEVVLAACEGIGSSMDDAVAELAANGLRVIAVAHRQLTAQQAQSVVDDPDEIARLCRDELSLVGFLGLSDTPRAQAAALLADLHEHDLDIRLITGDHPITAAAIAEELGMQVSPEQVISGAEWDALSRKDQERAVAERVIFARMTPENKVQIVQTLEHSGRVCAMVGDGSNDAAAIRAATVGIGVVAHGSDPARVAADLVLVDGRIESLLPAILEGRQLWQRVQAAVSVLLGGNAGEVAFAIIGSAITGTSPLNTRQLLLVNMLTDALPAAALAVSKPSDPVTPATRGPDQRELWRAVGIRGATTAAAATVAWVMAGFTGLPRRASTVALVALVAAQLGQTLVDSHAWLVVLTALGSLAALATLISIPVVSQLLGCTPLDPLGWAQATAAATAATVAVAVLNRVLTGRDKSGQPNPQPPETDALSRDASPGAPPGPRRRRRATARRKAPVKAPSATRQTTKPKGPPAHRSSSTYPRR
Protein: Vacuolar protein sorting-associated protein 32 homolog 2 (AtVPS32-2) (Charged multivesicular body protein 4 homolog 2) (ESCRT-III complex subunit VPS32 homolog 2) (Q9SZE4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity).
Subcellular location: Endosome {ECO:0000250}.
Interaction partners:
- Vacuolar-sorting protein BRO1
- Vacuolar protein sorting-associated protein 2 homolog 2
- Vacuolar protein sorting-associated protein 24 homolog 1
- Vacuolar protein sorting-associated protein 2 homolog 3
- Vacuolar protein sorting-associated protein 36
- Vacuolar protein sorting-associated protein 2 homolog 1
- Vacuolar protein sorting-associated protein 20 homolog 2
- Putative vacuolar protein sorting-associated protein 24 homolog 2
- SNF7 family protein
- ESCRT-related protein CHMP1A
Sequence:
MMNRLFGKPKQEANALQTLDKLNETLEMLEKKEKVLLKKAGAEVEKAKEYSRAKNKRAAIQCLKRKRLYEGQVEQLGNFQLRIHDQMIMLEGAKATTETVDALRSGASAMKAMQKATNIDDVDKTMDEINEQTENMKQIQEALATPMGAAADFDEDELAAELDELESEELESQLLQPATTAPPLPSVPVPAGRQPARPVPQKRTAEEEELAALQAEMAL