wanglab/gogpt-training-data huggingface dataset:
Protein: Mitochondrial mRNA pseudouridine synthase RPUSD3 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 3) (Q6P087)
Organism: Homo sapiens (Human)
Function: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:27974379}. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. {ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}.
Interaction partners:
- Neugrin
- Pseudouridylate synthase TRUB2, mitochondrial
- Pseudouridylate synthase PUS7L
- Mitochondrial assembly of ribosomal large subunit protein 1
- Pseudouridylate synthase 7 homolog
- FAST kinase domain-containing protein 2
- 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial
- RNA pseudouridylate synthase domain-containing protein 1
- RCC1-like G exchanging factor-like protein
- Pseudouridylate synthase 1 homolog
Sequence:
MRAVLAREMDGRRVLGRFWSGWRRGLGVRPVPEDAGFGTEARHQRQPRGSCQRSGPLGDQPFAGLLPKNLSREELVDALRAAVVDRKGPLVTLNKPQGLPVTGKPGELTLFSVLPELSQSLGLREQELQVVRASGKESSGLVLLSSCPQTASRLQKYFTHARRAQRPTATYCAVTDGIPAASEGKIQAALKLEHIDGVNLTVPVKAPSRKDILEGVKKTLSHFRVVATGSGCALVQLQPLTVFSSQLQVHMVLQLCPVLGDHMYSARVGTVLGQRFLLPAENNKPQRQVLDEALLRRLHLTPSQAAQLPLHLHLHRLLLPGTRARDTPVELLAPLPPYFSRTLQCLGLRLQ
Protein: Ribulose bisphosphate carboxylase small subunit (RuBisCO small subunit) (Q31NB2)
Organism: Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2)
Function: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
Subcellular location: Carboxysome {ECO:0000255|HAMAP-Rule:MF_00859, ECO:0000269|PubMed:17675289, ECO:0000269|PubMed:22928045, ECO:0000269|PubMed:24585024, ECO:0000269|PubMed:28616951, ECO:0000269|PubMed:31048338, ECO:0000269|PubMed:32636267, ECO:0000305|PubMed:24267892}. Note=In the carboxysome RuBisCO is organized into a paracrystalline array (PubMed:28616951). This cyanobacterium makes beta-type carboxysomes (PubMed:22928045). {ECO:0000269|PubMed:22928045, ECO:0000269|PubMed:28616951}.
Interaction partners:
- Ribulose bisphosphate carboxylase large chain
- Carboxysome assembly protein CcmM
- Phosphoribulokinase
- Phosphoglycerate kinase
- HAD family hydrolase
- Phosphoglycolate phosphatase
- Glycerate kinase
- RuBisCO chaperone RbcX
- Carboxysome shell protein CcmK2
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Sequence:
MSMKTLPKERRFETFSYLPPLSDRQIAAQIEYMIEQGFHPLIEFNEHSNPEEFYWTMWKLPLFDCKSPQQVLDEVRECRSEYGDCYIRVAGFDNIKQCQTVSFIVHRPGRY
Protein: Tyrosine-protein kinase csk-1 (EC 2.7.10.2) (C-terminal src kinase) (G5ECJ6)
Organism: Caenorhabditis elegans
Function: Non-receptor tyrosine-protein kinase which plays a role in pharynx function by regulating pumping and the orientation of pharyngeal muscle fibers, independently of src-1 and src-2. May phosphorylate and thereby negatively regulate src-1 and src-2 activities.
Interaction partners:
Sequence:
MSNGNSYNHHHQFPMSIPISCSSHSIQSQSRMNTLNANRDLLSPGNDVIVTRTVSPSFYSHGMPARDNVFRKDDHVRILGNTTDPAWYRARNANQEEGLVHADCVVRINGQAYDNGIVRMRASGCDVAPGAASTTSSTSSHHSTAANHQPWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSSTVDLEDRTSVFRHAGLVISSNDIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGMLDSLLDEAKFMVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRHALERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTIRNTV
Protein: Pyruvate dehydrogenase E1 component subunit alpha (EC 1.2.4.1) (P47516)
Organism: Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium)
Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Interaction partners:
- Pyruvate dehydrogenase E1 component subunit beta
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoyl dehydrogenase
- L-lactate dehydrogenase
- Pyruvate kinase
- Probable lipoate-protein ligase A
- Glucose-6-phosphate isomerase
- Transketolase
- Fructose-bisphosphate aldolase
- NADH oxidase
Sequence:
MAILIKNKVPTTLYQVYDNEGKLIDPNHKITLTDEQLKHAYYLMNLSRMMDKKMLVWQRAGKMLNFAPNLGEEALQVGMGLGLNENDWVCPTFRSGALMLYRGVKPEQLLLYWNGNEKGSQIDAKYKTLPINITIGAQYSHAAGLGYMLHYKKQPNVAVTMIGDGGTAEGEFYEAMNIASIHKWNTVFCINNNQFAISTRTKLESAVSDLSVKAIACGIPRVRVDGNDLIASYEAMQDAANYARGGNGPVLIEFFSYRQGPHTTSDDPSIYRTKQEEEEGMKSDPVKRLRNFLFDRSILNQAQEEEMFSKIEQEIQAAYEKMVLDTPVSVDEVFDYNYQELTPELVEQKQIAKKYFKD
Protein: Nitric oxide-associated protein 1 (Q8NC60)
Organism: Homo sapiens (Human)
Function: Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:19103604}; Peripheral membrane protein {ECO:0000269|PubMed:19103604}; Matrix side {ECO:0000269|PubMed:19103604}.
Interaction partners:
- Small ribosomal subunit protein mS27
- GTPase Era, mitochondrial
- Small ribosomal subunit protein mS34
- Dimethyladenosine transferase 1, mitochondrial
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein mS40
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein bS6m
Sequence:
MLPARLPFRLLSLFLRGSAPTAARHGLREPLLERRCAAASSFQHSSSLGRELPYDPVDTEGFGEGGDMQERFLFPEYILDPEPQPTREKQLQELQQQQEEEERQRQQRREERRQQNLRARSREHPVVGHPDPALPPSGVNCSGCGAELHCQDAGVPGYLPREKFLRTAEADGGLARTVCQRCWLLSHHRRALRLQVSREQYLELVSAALRRPGPSLVLYMVDLLDLPDALLPDLPALVGPKQLIVLGNKVDLLPQDAPGYRQRLRERLWEDCARAGLLLAPGHQGPQRPVKDEPQDGENPNPPNWSRTVVRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGATNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKPPSLMYNVRKKKGKINV
Protein: Emb|CAB62602.1 (Mitochondrial transcription termination factor family protein) (Q9LV83)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Mitochondrial transcription termination factor family protein
- Mitochondrial transcription termination factor-related / mTERF-like protein
- Transcription termination factor family protein
Sequence:
MQFLASLVSNSRKFGRRWDRALSLHHFSSNATPASISNPAFVEFLRDNGFQKPLAIAIAMRYPNLKSLEQPRSVIQMLKSYSFSDTQIQKSIRVHPRMMFYNVEKILEPKLRFFKDIGFTGSGLGKFVSQNSSVVGVSLVKKLIPTVEILKSIVAPKHEDLPVILSRCGWLLLSRDPNLFLLPNISYLETCGIVGSQLASLLRRQPRIFNLSEEKLRGYVSRALDLGFTLNSRMLVHAVISLSSLSEKTFDRKVKLFMANGFSEDEITDIIRRSPGLIRCSEDKLTLGFEFYLKRMGLEREALAKRPCVLSYNLEKRVIPRLKVLQILREKGLLLKEEKKKKNMVGIVEMTEEAFLEKYVVRFGDEIAEELLVAYKCVCLVDETLLDRIKI
Protein: Glutamate dehydrogenase (Q9VCN3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Glutamate synthase
- omega-amidase
- Aspartate aminotransferase
- Aspartate aminotransferase, cytoplasmic
- Malate dehydrogenase
- alanine transaminase
- Citrate synthase
- GH20963p
- Glutamine synthetase 2 cytoplasmic
- Glutamine synthetase 1, mitochondrial
Sequence:
MLRYTARILNGIYPLMPRQVLKRSAHQVPEKLKKVETDKDPEFSEMVLYYYHKAAQTMEPALLKEMEKYPHMKPEERQARVTAILNLLGSVSTSVEVNFPIVRKNGTYEIISGYRSHHVRHRLPLKGGIRYALDVNESEVKALAAIMTFKCACVNVPYGGSKGGICIDPKKYTVDELQTITRRYTMELLKRNMIGPGIDVPAPDVNTGPREMSWIVDQYQKTFGYKDINSSAIVTGKPVHNGGINGRHSATGRGVWKAGDLFLKDKEWMDLLKWKTGWKDKTVIVQGFGNVGSFAAKYVHEAGAKVIGIKEFDVSLVNKDGIDINDLFEYTEEKKTIKGYPKAQESKEDLLVAETDILMPCATQKVITTDNAKDIKAKLILEGANGPTTPSGEKILLDKGVLLVPDLYCNAGGVTVSYFEYLKNINHVSYGKMNSKSTSELIIELMNSINESLHECPDSQLPNICPNKKLKRIQQCTTEADIVDSALQTVMESAARGIKEMAHKFELCNDLRRAAYVWSSFKIFQAMESSGISQQ
Protein: Amorpha-4,11-diene synthase (EC 4.2.3.24) (Q9AR04)
Organism: Artemisia annua (Sweet wormwood)
Function: Involved in the biosynthesis of the antimalarial endoperoxide artemisinin. Catalyzes the formation of both olefinic and oxygenated sesquiterpenes, with amorpha-4,11-diene being the major product.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MSLTEEKPIRPIANFPPSIWGDQFLIYEKQVEQGVEQIVNDLKKEVRQLLKEALDIPMKHANLLKLIDEIQRLGIPYHFEREIDHALQCIYETYGDNWNGDRSSLWFRLMRKQGYYVTCDVFNNYKDKNGAFKQSLANDVEGLLELYEATSMRVPGEIILEDALGFTRSRLSIMTKDAFSTNPALFTEIQRALKQPLWKRLPRIEAAQYIPFYQQQDSHNKTLLKLAKLEFNLLQSLHKEELSHVCKWWKAFDIKKNAPCLRDRIVECYFWGLGSGYEPQYSRARVFFTKAVAVITLIDDTYDAYGTYEELKIFTEAVERWSITCLDTLPEYMKPIYKLFMDTYTEMEEFLAKEGRTDLFNCGKEFVKEFVRNLMVEAKWANEGHIPTTEEHDPVVIITGGANLLTTTCYLGMSDIFTKESVEWAVSAPPLFRYSGILGRRLNDLMTHKAEQERKHSSSSLESYMKEYNVNEEYAQTLIYKEVEDVWKDINREYLTTKNIPRPLLMAVIYLCQFLEVQYAGKDNFTRMGDEYKHLIKSLLVYPMSI
Protein: Transcription factor 7-like 1-B (HMG box transcription factor 3-B) (TCF-3-B) (Q800Q5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Also required for hindbrain morphogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- Catenin beta-1
- B-cell CLL/lymphoma 9 protein isoform X1
- Catenin, beta 2.
Sequence:
MPQLNGGGGDELGANDEMISFKDEGEQEDKISENVSAERGLDDVKSSLVSESENNSSSSDSEQTERRPQPRADLESYEKAREYFTEALRRQQDGGFFKSPHYPGYPFLMIPDLANPYLSNGALSPSARTYLQMKWPLLDVPGSAALKDSQSPSPGHLSNKVPVVQHAHMHPLTPLITYSNEFPPGTPPAHLSPEILDPKTGIPRTPHPAELSPYYPLSPGTVGQIPHPLGWLVPQQGQHMYPITAGGFRHPYPALAMNASMSSLVSSRFSPHLVPHHPHGLHQTGIPHPAIVSPVIKQEPNGELSPPVNTKSPGPNKKDEDKKPHIKKPLNAFMLYMKEMRAKVVAECTLKENAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYGKRKKRKRDNKTDSTPEDFSMRSKKPCVQYLPQEKMIDSPGSSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPERFPLLSKPPPSSSSSSSSSSSSGLPTPPLLSRPLPFALLTPPSPFHQAALHSHHALFQSQPLSLVTKSSD
Protein: Monocarboxylate transporter 12 (MCT 12) (Creatine transporter 2) (CRT2) (Solute carrier family 16 member 12) (Q6ZSM3)
Organism: Homo sapiens (Human)
Function: Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:23578822, ECO:0000269|PubMed:31784090, ECO:0000269|PubMed:32249133}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8BGC3}; Multi-pass membrane protein {ECO:0000255}. Note=Interaction with isoform 2 of BSG is required for its localization to the plasma membrane. {ECO:0000269|PubMed:26376857}.
Interaction partners:
Sequence:
MPSGSHWTANSSKIITWLLEQPGKEEKRKTMAKVNRARSTSPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDHTTPEQNHVCRTQKEDIKRVSPYSSLTKEWAQTCLCCCLQQEYSFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMDGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLGFARLIKRMRKTQLQFIAKESDPKLQLWTNGSVAYSVARELDQKHGEPVATAVPGYSLT
Protein: Venom prothrombin activator notecarin-D2 (vPA) (EC 3.4.21.6) (Venom coagulation factor Xa-like protease) [Cleaved into: Notecarin-D2 light chain; Notecarin-D2 heavy chain] (Q58L94)
Organism: Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
Function: Snake prothrombin activator that attacks the hemostatic system of prey. This protein is functionally similar to blood coagulation factor Xa.
Subcellular location: Secreted {ECO:0000269|PubMed:12403650}.
Interaction partners:
Sequence:
MAPQLLLCLILTFLWSLPEAESNVFLKSKVANRFLQRTKRSNSLFEEIRPGNIERECIEEKCSKEEAREVFEDNEKTETFWNVYVDGDQCSSNPCHYRGTCKDGIGSYTCTCLPNYEGKNCEKVLFKSCRAFNGNCWHFCKRVQSETQCSCAESYLLGVDGHSCVAEGDFSCGRNIKARNKREASLPDFVQSQKATVLKKSDNPSPDIRIVNGMDCKLGECPWQAVLINEKGEVFCGGTILSPIHVLTAAHCINQTKSVSVIVGEIDISRKETRRLLSVDKIYVHKKFVPPNSYYQNIDRFAYDYDIAIIRMKTPIQFSENVVPACLPTADFAKEVLMKQDSGIVSGFGRTQSIGYTSNILKVITVPYVDRHTCMLSSNFRITQNMFCAGYDTLPQDACQGDSGGPHITAYGDTHFVTGIISWGEGCARKGKYGVYTKVSNFIPWIKKIMSLK
Protein: RE45450p (Q8MYY5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQSVTRLLSTTLTIQTPFRTAPAFLQQLRGKTKVVEKPKPGAGQQFRRTVHFPEKYTVEPLKITHLAGRDPVSGRLVAKGIGGGIKQQYRWVKWVRDGPTEGAQEELVLEVLRDGCRTAKVALVAVGDELKYILATENMKAGDILKTSRFIPRIPVRPNEGDAYPLGALPVGTRIHCLEKNPGQMCHLIHAAGTFGTILRKFDEKVVVQLPSKREFAFQRTCMATVGRLSNPEHNKEHVGSAQRMREMGNRPRSGLWKRKEGKHGRKIRRLTPMTTISPPAPPKEEAIKLTLPL
Protein: Os05g0585900 protein (cDNA clone:J013000H16, full insert sequence) (Q6I583)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate dehydrogenase iron-sulfur subunit 1, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Aspartate aminotransferase
- Aspartate aminotransferase, cytoplasmic
Sequence:
MASEDVVGKSRGDTAVTTIVNLAEEAKLAREGVKGPGYQVLSICKSLFAGGVAGGVSRTAVAPLERMKILLQVQNPHSIKYNGTIQGLKYIWRTEGLRGLFKGNGTNCARIVPNSAVKFFSYEQASSGILWLYRQQTGNEDAQLSPLLRLGAGACAGIIAMSATYPMDMVRGRITVQTEKSPYQYRGMFHALGSVYREEGFRALYRGWLPSVIGVVPYVGLNFAVYESLKDWLLQTNPYDLGKDNELHVVTRLGCGAVAGTIGQTVAYPLDVIRRRMQMVGWNNAASIVTGEGKEALQYNGMIDAFRKTVRYEGVGALYKGLVPNSVKVVPSIAIAFVTYEFVQKVLGVEMRISD
Protein: Flagellum-specific ATP synthase (EC 7.1.2.2) (O07025)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Flagellar assembly protein FliH
- Flagellar biosynthetic protein FliQ
- Flagellar motor switch protein FliN
- Flagellar biosynthesis protein FlhA
- Flagellar biosynthetic protein FlhB
- Flagellar motor switch protein FliG
- Flagellar biosynthetic protein FliP
- Flagellar motor switch protein FliN
- Flagellar basal-body rod protein FlgC
- Flagellar hook-basal body complex protein FliE
Sequence:
MPLKSLKNRLNQHFDLSPRYGSVKKIMPNIVYADGFNPSVGDVVKIEKSDGSECVGMVVVAEKEQFGFTPFNFIEGARAGDKVLFLKEGLNFPVGRNLLGRVLNPLGQVIDNKGALDYERLAPVITTPIAPLKRGLIDEIFSVGVKSIDGLLTCGKGQKLGIFAGSGVGKSTLMGMITRGCLAPIKVIALIGERGREIPEFIEKNLKGDLSSCVLVVATSDDSPLMRKYGAFCAMSVAEYFKNQGLDVLFIMDSVTRFAMAQREIGLALGEPPTSKGYPPSALSLLPQLMERAGKEENKGSITAFFSVLVEGDDLSDPIADQTRSILDGHIVLSRELTDYGIYPPINILNSASRVAKDIISESQNLCARKFRRLYALLKENEMLIRIGSYQMGNDKELDEAIKKKALMEQFLAQDENALQPFETSFQQLEEILR
Protein: L-lactate dehydrogenase (EC 1.1.1.27) (E3TG57)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MASTKEKLIAHVSTEQPVGCTNKVTAVGVGMVGMAAAISILLKELTDELALVDVMEDKLKGEAMDLQHGSLFLKTHKIVADKDYSVTANSKVVVVSNPVDILTYVAWKLSGLPRNRVIGSGTNLDSARFRFLMGEKLGLHASSCHGWVIGEHGDSSVPVWSGVNVAGVSLQGLNPDMGTDKDKDEWKNVHKMVVDSAYEVIKLKGYTSWAIGMSVADLCESILKNLHKCHPVSTLVKGMHGVNDEVFLSVPCVLGSSGLTDVVKMTLKPEEEKQLVKSAETLWGVQKELTL
Protein: Dyp-type peroxidase family protein (Q556V8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Ras guanine nucleotide exchange factor F
Sequence:
MAQSTVLPMHCLYGIFLEGNLKIQKNDQEGLKKFKDNIKKFTLELDEIDKISPQSRIGGAICFSSDIWDTVTKKISKPKELKSVNTLSSYMPGTSQRDILIHIISDRMDTCFKLAQDTMRNFGEDQLDIKQEIHGFRRVEERDLTDFIDGTENPDGDELRTQYGLVAAGQPNEFGSYVFTQRYVHNLKKWYPEPLSVQQDTVGRTKKDSIEIPRDKRPITSHVSRTDLSENGKDLKIVRQSLPYGQITGEKGLMFIAYACSLHNIEKQLQSMFGQLDGKHDLLLKYTTPVTGSFYFAPSKKELLEL
Protein: Myosin light chain 6B (Smooth muscle and nonmuscle myosin light chain alkali 6B) (Q8CI43)
Organism: Mus musculus (Mouse)
Function: Regulatory light chain of myosin. Does not bind calcium.
Interaction partners:
- Myosin-10
- Myosin-9
- Myosin-11
- Myosin, light chain 12A, regulatory, non-sarcomeric
- Myosin regulatory light chain 12B
- Myosin regulatory light polypeptide 9
- Myosin light polypeptide 6
- Myosin light chain kinase 3
- Myosin light chain kinase 2, skeletal/cardiac muscle
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Sequence:
MPPKKDAPVKKPAGPSISKPAAKSTPGTPLAKAKAEPAAPQAPAKSQEPPVDLSKVVIEFNKDQLEEFREAFELFDRVGDGKILYSQCGDLMRALGQNPTNAEVLKVLGNPKNEELKSRRVDFETFLPMLQAVAKNRDQGTYEDYLEGLRVFDKEGNGKVMGAELRHVLTTLGEKMTEEEVETVLAGHEDSNGCINYEAFLKHILSL
Protein: Mitogen-activated protein kinase kinase 6 (AtMKK6) (MAP kinase kinase 6) (EC 2.7.12.2) (Protein Arabidopsis NQK1 homolog) (Q9FJV0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis. MKK6-MPK13 module positively regulates lateral root formation. Phosphorylates and activates MPK4. Activates MPK5 and MPK13 in vitro.
Subcellular location: Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:20802223}. Note=Localized at the equatorial plane of the phragmoplast.
Interaction partners:
- Mitogen-activated protein kinase 4
- Mitogen-activated protein kinase kinase kinase 1
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 13
- Mitogen-activated protein kinase 6
- Mitogen-activated protein kinase 11
- Kinesin-like protein KIN-7A
- Kinesin-like protein KIN-7B
- F12F1.31 protein
- Protein JASON
Sequence:
MVKIKSNLKQLKLSVPAQESPISSFLTASGTFHDGDFLLNQKGLRLTSDEKQSRQSDSKELDFEITAEDLETVKVIGKGSGGVVQLVRHKWVGKFFAMKVIQMNIQEEIRKQIVQELKINQASSQCPHVVVCYHSFYHNGAFSLVLEYMDRGSLADVIRQVKTILEPYLAVVCKQVLLGLVYLHNERHVIHRDIKPSNLLVNHKGEVKISDFGVSASLASSMGQRDTFVGTYNYMSPERISGSTYDYSSDIWSLGMSVLECAIGRFPYLESEDQQNPPSFYELLAAIVENPPPTAPSDQFSPEFCSFVSACIQKDPPARASSLDLLSHPFIKKFEDKDIDLGILVGTLEPPVNYLR
Protein: Transcription elongation factor 1 homolog (Q4GZ56)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364033}.
Interaction partners:
- Transcription initiation protein, putative
- Spt4/RpoE2 zinc finger domain-containing protein
- DNA-directed RNA polymerase subunit beta
- Cell division control protein 73 C-terminal domain-containing protein
- Plastid-encoded RNA polymerase subunit alpha
- DNA-directed RNA polymerase II, putative
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- RNA polymerase-like protein
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- FACT complex subunit
Sequence:
MGGTKKKATVPIKKESKYKIPSHFDCPFCDAKKSIAVRLKRSDGLASVHCRVCRVGENRHYNFSPLEKPVDVFFRFREELMEKDHELLRAHNVETGAMAARTGLAQLAPKNRQQATLEEDMASAEPSDYDNFLSTVENISRSALLASDIHVDSEYDEPLF
Protein: NF-kappa-B inhibitor cactus (Q03017)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1423618}.
Interaction partners:
- Embryonic polarity protein dorsal
- Dorsal-related immunity factor Dif
- Serine/threonine-protein kinase pelle
- Supernumerary limbs, isoform B
- Protein spaetzle
- Nuclear factor NF-kappa-B p110 subunit
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- LD20892p
- Protein toll
- Protein Tube
Sequence:
MPSPTKAAEAATKATATSDCSCSAASVEQRAPSNAANPSSSLATSGKIGGKTQDQTAAINKQKEFAVPNETSDSGFISGPQSSQIFSEEIVPDSEEQDKDQQESAPQKEQPVVLDSGIIDEEEDQEEQEKEEEHQDTTTATADSMRLKHSADTGIPQWTVESHLVSRGEQLNNLGQSSSTQITGRSKVQSSTASTANANPSGSGATSSAPPSSINIMNAWEQFYQQNDDGDTPLHLACISGSVDVVAALIRMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMRILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSNDKAVSSLSYACLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNEDLANFLLDECEKLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAETVTPPDSDYDSSDIEDLDDTKMYDRFGDPRYFVSYNGGNPMTVA
Protein: Autophagy-related protein 3 (Autophagy-related E2-like conjugation enzyme ATG3) (P40344)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11149920, ECO:0000269|PubMed:14562095}. Mitochondrion {ECO:0000269|PubMed:30510114}. Note=Associates with mitochondria following nitrogen starvation in a respiratory carbon source. {ECO:0000269|PubMed:30510114}.
Interaction partners:
- Autophagy-related protein 8
- Cysteine protease ATG4
- Ubiquitin-like protein ATG12
- Autophagy protein 16
- Autophagy protein 5
- Serine/threonine-protein kinase ATG1
- Ubiquitin-like modifier-activating enzyme ATG7
- Putative lipase ATG15
- Vacuolar protein sorting-associated protein 30
- Ubiquitin-like-conjugating enzyme ATG10
Sequence:
MIRSTLSSWREYLTPITHKSTFLTTGQITPEEFVQAGDYLCHMFPTWKWNEESSDISYRDFLPKNKQFLIIRKVPCDKRAEQCVEVEGPDVIMKGFAEDGDEDDVLEYIGSETEHVQSTPAGGTKDSSIDDIDELIQDMEIKEEDENDDTEEFNAKGGLAKDMAQERYYDLYIAYSTSYRVPKMYIVGFNSNGSPLSPEQMFEDISADYRTKTATIEKLPFYKNSVLSVSIHPCKHANVMKILLDKVRVVRQRRRKELQEEQELDGVGDWEDLQDDIDDSLRVDQYLIVFLKFITSVTPSIQHDYTMEGW
Protein: Potassium transporter (F4IIZ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU321113}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU321113}.
Interaction partners:
Sequence:
MAARVEAATMGGEIDEEESDERGSMWDLDQKLDQSMDEEAGRLRNMYREKKFSALLLLQLSFQSLGVVYGDLGTSPLYVFYNTFPHGIKDPEDIIGALSLIIYSLTLIPLLKYVFVVCKANDNGQGSGTFALYSLLCRHAKVKTIQNQHRTDEELTTYSRTTFHEHSFAAKTKRWLEKRTSRKTALLILVLVGTCMVIGDGILTPAISVLSAAGGLRVNLPHISNGVVVFVAVVILVSLFSVQHYGTDRVGWLFAPIVFLWFLSIASIGMYNIWKHDTSVLKAFSPVYIYRYFKRGGRDRWTSLGGIMLSITGIEALFADLSHFPVSAVQIAFTVIVFPCLLLAYSGQAAYIRRYPDHVADAFYRSIPGSVYWPMFIIATAAAIVASQATISATFSLVKQALAHGCFPRVKVVHTSRKFLGQIYVPDINWILMILCIAVTAGFKNQSQIGNAYGTAVVIVMLVTTLLMTLIMILVWRCHWVLVLIFTVLSLVVECTYFSAMLFKIDQGGWVPLVIAAAFLLIMWVWHYGTLKRYEFEMHCRVSMAWILGLGPSLGLVRVPGVGLVYTELASGVPHIFSHFITNLPAIHSVVVFVCVKNLPVYTVPEEERFLVKRIGPKNFHMFRCVARYGYRDLHKKDDDFEKRLFESLFLYVRLESMMEGGCSDSDDYSICGSQQQLKDTLGNGNENENLATFDTFDSIESITPVKRVSNTVTASSQMSGVDELEFINGCRDAGVVHIMGNTVVRARREARFYKKIAIDYVYAFLRKICREHSVIYNVPQESLLNVGQIFYV