wanglab/gogpt-training-data huggingface dataset:
Protein: Meiotic drive suppressor wtf13 (A0A482AR57)
Organism: Schizosaccharomyces kambucha (Fission yeast)
Function: Acts as a suppressor component of the dual wtf meiotic drive system, and can suppress but not confer meiotic drive by compatible poisons. Wtf meiotic drive systems promote unequal transmission of alleles from the parental zygote to progeny spores by encoding a poison and an antidote from the same locus; the poison is trans-acting and forms toxic aggregates in all spores within an ascus, wherease the antidote is spore-specific and targets aggregates for degradation by the vacuole (By similarity). Meiotic drive by wtf systems therefore lead to poisoning of all progeny that do not inherit the dual poison/antidote allele, or express a compatible antidote (By similarity).
Subcellular location: Spore membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKNNYTSLKSSMDEGDELKTGHEFDLEKGILPEYNSEEEGALPPYSDISKLANPVPEDSSTGPTETTNPNVERRQEFKDSHPNIYSLLRLLISVLAVIVVFFTAWVCVNPLEKSIFGKVAFSVTIGITCPIVFIAIFCFFETWTQAVAQCIKVTVIFLAQCVKVTVISLAKCVKVIAVGLYNSKKDLVVTIWLAWVVICFILFGCVKDGRLNLNKALICSTSSISAALFFILLLVCIPIWTLKHMLFGLFQVLGVQSCVVIVTKGLMYLLDKHIDATGYEIEASSLFVIGNFLFFYEMERPGALKRMPKFIGNGIASFLGGIANAIRGIANAIGGIANAFRGANDNNDIPLGEMDVESEV
Protein: Iroquois-class homeodomain protein IRX-1 (Homeodomain protein IRXA1) (Iroquois homeobox protein 1) (P78414)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- A-type voltage-gated potassium channel KCND2
- Histone-lysine N-methyltransferase SMYD1
- Heart- and neural crest derivatives-expressed protein 2
Sequence:
MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTAPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQSNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLKPQDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPPPAGHPGAHGPSAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAPGALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
Protein: Protein SHQ1 (Small nucleolar RNAs of the box H/ACA family quantitative accumulation protein 1) (P40486)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the early biogenesis steps of box H/ACA snoRNP assembly.
Subcellular location: Nucleus {ECO:0000269|PubMed:12228251, ECO:0000269|PubMed:14562095}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit CBF5
- H/ACA ribonucleoprotein complex subunit NOP10
- H/ACA ribonucleoprotein complex subunit GAR1
- H/ACA ribonucleoprotein complex subunit NHP2
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- Nucleolar protein 58
- RuvB-like protein 1
- RuvB-like protein 2
- 13 kDa ribonucleoprotein-associated protein
- Nucleolar protein 56
Sequence:
MITPRFSITQDEEFIFLKIFISNIRFSAVGLEIIIQENMIIFHLSPYYLRLRFPHELIDDERSTAQYDSKDECINVKVAKLNKNEYFEDLDLPTKLLARQGDLAGADALTENTDAKKTQKPLIQEVETDGVSNNIKDDVKTIGQMGEGFNWEIEQKMDSSTNNGILKTKYGFDNLYDTVISVSTSNGNDINELDDPEHTDANDRVIERLRKENLKFDPEYYVSEYMTHKYGNEEDLEINGIKELLKFTPSIVKQYLQWYKDSTNPNLVMPIEFTDEEQKQMQDNLPKKSYLVEDIKPLYVTILSVLFSYVFEQIENEGTHTTESAWTMGKLCPQISFLDQQLKQVNELQDGMKEISKVNKDSSLIKIAIITGIRRALSYPLHRNYDLAMKAWTFVYYILRGGKRLVIRALLDIHETFRFHDVYYVYDKVLLDDLTAWFISQGSENVIRSLALEMRKEQESLSKQDIEFECIASFNEQTGEPEWETLNIREMEILAESEYREQQQNPQ
Protein: Putative truncated guanine nucleotide exchange factor YLL017W (P0CF33)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MSCTASYAGMTTPVKDKEGHGIPCLQPIDVVECTYQYFTKSRNKLSLRVGDLIYVLTKGSNGWWDGVLIRHSANNNNNSLILDRGWFPPSFYTVHSKRTTRGA
Protein: Os02g0726700 protein (Q6Z339)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
- Os03g0726900 protein
Sequence:
MEIRRSLRPLDLAKQRGRSSGNGTAAGSAVDGASPAGSDSEEHVLPGGVGTFSIRHASGTPSREEAGSHGGVRRSAFAFAPALHGARMENAHETGGRSGSRAHRAPSTMWQDSAIDQRSIGQTPYEATRAEGRSSASSADQGPSTPRSKHSATEQRRRTKINDRLEILRELLPHTDQKRDKASFLSEVIEYIRFLQEKVQKYEEADPERNHEDSKSMPWAKVYYRSCWRNTKNTSQVQGEDLSPSTQDMNNEQYGPKHISAAQPALFNTQSVTSTTTSSSHMATGTPQNLEKNSTPSNQPPWLSMSTMRQESEPGNKMPNKHEKQTLHDENHSISSAYSQGSVP
Protein: Sulfhydryl oxidase (EC 1.8.3.2) (Q9VD62)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Serpin 28F
- IP20609p
- Uncharacterized protein, isoform A
- Accessory gland protein Acp29AB
- Accessory gland-specific peptide 26Ab
- Ero1-like protein
- Accessory gland-specific peptide 26Aa
- GH11711p
- Lectin-29Ca
- Aquarius
Sequence:
MVWHFWVPYLTCIILILIVQEGHSKQRCLDEEPPLYSKEDNIHVVVGASLKKILAEPAMGKLVQFLNSYCGNCRRFAHTFRKMAVDLQKWNRVLRIYAVDCARLENVKLCRDFRITLTPTIRYYPSKFQRIRHGIGTDIETTIPSEIADQLIESLSENDYSESKGVKPIFDPIEPGNKLNDIYEQFDNKVTYILLVHPVDMGIETILNMLPYPDVGVRIIKDAEMFAQFGLKPCKQMVALLNRSGKAQLIKPAGKSSSAYVESVAGLLHQNGHTSMPTLPPAEPEYILSEGYDAFIVDYVLNSTKVLFQADLEQAIYQFLHVEIPKTAFISGFKFKALRHIIRLFRRFNVLNRDGRRMLNSLVNHLFEVTEITGEEFRDVVDDLQTRLDPIFAEQQYVGCLGSTPHTRRFSCSLWTLFHYFTVLAAQMKVYPPSSVTIGLYGLAKFFYDCKDGSMYFVKLAKRMNIAKVRTHDEEILWLWEAHNEVNEKLAGDASGDPRFPKVQFPERKHCPDCYTHSGEFDRDEVLKYLKRVYNLSYLSGDAEPHSRRSNECKSKKKYLQK
Protein: FAD dependent oxidoreductase domain-containing protein (C8JQS2)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTPKIAIIGEGVIGCSTALQVAQAVPDARVTVLSDRPFEQTCSFGPAGLFRIDDIANREFGKSTFDWFAHLHRTEKGDKTGVKLLSGHIQSDSKERLEQQQKAYGDIVYNFRFLEKREILDLFPNPSEHCIHYTAFASEGNKYVPYLKFQCQARGVEFLHRKVRDLEEGEQCCNRLGEAGKPLGSGNYGCRPERYFGKIRCTASGYEGAKNLRGVVRAQTSSEDYSD
Protein: Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) (P48506)
Organism: Homo sapiens (Human)
Function: Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.
Interaction partners:
- Glutamate--cysteine ligase regulatory subunit
- Glutathione synthetase
- Nuclear factor erythroid 2-related factor 2
- 5-oxoprolinase
- Glutathione hydrolase 1 proenzyme
- Glutathione hydrolase 6
- Aminopeptidase N
- Glutathione hydrolase 7
- Glutathione hydrolase 5 proenzyme
- Gamma-glutamylcyclotransferase
Sequence:
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (Q8SZT4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
Sequence:
MRQTPLPPYSSIACGMDCSSSNSSSCGQSLSLSQGQGHNNNNSHPYRRLPNHMDVLPPPPSACDRCCTAPGYSCASSCDDMLIDGSDLDQDRSPDQGQVQPVDRRMISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDFEALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWEPHVTASRLFFWRELWNAKELKRLPTCPAARDCIYMCCNPLHWFRILHQPETESPTPPYQRSKMLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYESVTTDGKDHNINSQVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLDRVCKVMPGYCLKAFETNRAELLSMRDHGHHPMGPVDYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLR
Protein: Angiotensin-converting enzyme (EC 3.4.-.-) (A0A1S3APE5)
Organism: Erinaceus europaeus (Western European hedgehog)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|PROSITE-ProRule:PRU01354}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|PROSITE-ProRule:PRU01354}. Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Neprilysin
- Lysosomal Pro-X carboxypeptidase
- Meprin A subunit
- Metalloendopeptidase
- Xaa-Pro aminopeptidase 2
- Interleukin-2
- Thiol proteinase inhibitor
Sequence:
MLGSFWLFLSLVAVTAAQTNIEEEAKKFLDDFNRQAENVSYESALASWNYNINITEENIQKMNDAGAKWSEFYEEQSKTARNYPLQDIQNPTVRRQLQILQQNGSSVLSADKIKRLNDILNRMSTIYSTGKVCKPDNPQDCLLLEPGLDRIMENSTDYNLRLWAWEGWRAVVGKQLRPLYEEYVELKNEMAKANNYEDYGDYWRGDYEAEGDAGYNYSREQLIEDVERTFAEIKPLYEHLHAYVRRKLMDTYPSHISPTGGLPAHLLGDMWGRFWTNLYRLTVPYGQKPNIDVTEEMVNQKWNADRIFKEAEKFFVSVGLPSMTEGFWNNSMLTEPQDGRKVVCHPTAWDLGNGDFRIKMCTKVTMDDFLTAHHEMGHIQYDMAYAQQPYLLRSGANEGFHEAVGEIMSLSAATPKHLKSIGLLPKDFSDDNETDINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPATLFHVANDYSFIRYYTRTIYQFQFQEALCREAKHEGPLYKCDISNSQEAGEKLLQMLKLGKSEPWTLALERVVGEKSMNVTPLLNYFEPLFTWLQLQNADSVVGWNEGGSSSSDQAIKVRISLKSALGDKAYEWNENEMYLFKSSVAYAMREYFSKVKNQTVLFGDNNVHVSNLTERVSFNFYVTSPETFAVIPRMEVEEAIRMSRGRINDVFRLDDNSLEFVGIYPTLAPPYEPPVTIWLIVFGVVMGVVVIGIIVLIITGIKERRKRNQASSEENPYASVDLNNGENNPGFQNSDDVQTSF
Protein: PX domain-containing protein EREX (Protein ENDOSOMAL RAB EFFECTOR WITH PX-DOMAIN) (Q9LSB9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as an effector of RABF2A and RABF2B. Involved in vacuolar transport of storage proteins. Regulates membrane trafficking to protein storage vacuoles (PSVs). Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:27288222}. Endosome membrane {ECO:0000269|PubMed:27288222}; Peripheral membrane protein {ECO:0000305}. Note=The endosomal localization depends on the active state of RABF2B. Binding of phosphatidylinositol 3-monophosphate via the PX domain is required for the endosomal localization. {ECO:0000269|PubMed:27288222}.
Interaction partners:
- WD40 repeat-containing protein HOS15
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 10
- Probable carboxylesterase 11
- Transcription and mRNA export factor ENY2
- Ubiquitin C-terminal hydrolase 22
- Transcription initiation factor TFIID subunit 5
- Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog
- Transcription initiation factor TFIID subunit 12b
- Transcription initiation factor TFIID subunit 12
Sequence:
MNLYAHDLSLLDFNYNVSGPFGEPLSHRFLSPGPFFQGEEDDYRRNTSYSHDGANGREPDTDSRASPPHRHDGRSPLPLGMDWSSPPRHLEGRDTVWPHDHRTGWSYCVTVPSWVDLPKSSVSDPAVFYRVQVAIQSPEGITSARLVLRRFNDFLELYSSIKKEFVKKSLPQAPPKKILRMRNQTLLEERRCSLEDWMNRLLSDIDISRSALIATFLELEAAVRSYFNDEYQETEDTSGDIPSLLPTTISDVPGSSSVTIDHDNDSADETSNASTMKHDEANLKNLFSRNSTAVDNVTDWHELITEYGLLDQSSFQEKVERLSSTNGDAATGTVTRGGISSGVGIQRLDGSDRKFQELTIESIKKTHVSDFEASTAVEPDLVNQGAMDIHGEAHGNMYGAVGGDTETQKDLAIVFQSEERHKLKRVIDTLKQRLETAKADTEDLISRLNQELAVRQFLSTKVRDLEVELETTRESCKQGMEKTVLDEKERFTQIQWDMEELRKQCMEMESFLNSIKDEKTHIETANESLVQENQMLLQQINDIRENFENFHKEHEELEVKAKAELKVLVKEVKSLRTTQSDLRQELSGIMKEKLEMERIVQREKDREETAKNADKKLLHECDVLQNRLQECNVKFDIEEEGKLIMDSSSLSEAIELLATSDNRIGLLIAETQLLSEEVEKLKLTSGGHRGTDDLVRKMLTEVLIDNARLRKQVNSVLRCSLSGHGISVREAGTEVDDEEGSIDLARTVMSKILEK
Protein: V(D)J recombination-activating protein 2 (G3V6K7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- V
- Histone H3.3
- T-cell surface glycoprotein CD4
- Transmembrane protein 232
- Histone H3.1
- Fumarylacetoacetase
- Interleukin 2 receptor, gamma, isoform CRA_a.
- DNA-dependent protein kinase catalytic subunit
- Receptor-type tyrosine-protein phosphatase C
- Interferon gamma
Sequence:
MSLQMVTVGHNIALIQPGFSLMNFDGQVFFFGQKGWPKRSCPTGVFHFDIKQNHLKLKPAVFSKDSCYLPPLRYPATCSYKGSTDSDKHQYIIHGGKTPNNELSDKIYIMSVACKNNKKVTFRCTEKDLVGDVPEARYGHSIDVVYSRGKSVGVLFGGRSYMPSTQRTTEKWNSVADCLPHVFLVDFEFGCATSYILPELQDGLSFHVSIARNDTIYILGGHSLASNIRPANLYRIRVDLPLGTPAVNCTVLPGGISVSSAIVTQTNNDEFVIVGGYQLENQKRMVCSIVSLGDNRIEISEMETPDWTPDIKHSKIWFGSNMGNGTVFLGIPGDNKQAMSEAFYFYMLRCSEDNSSEEQKIVSNSQTSTEDAGDSTPFEDSEEFCFSAEAISFDGDDEFDTYNEDDEDDESVTGYWITCSPTCDVDINTWVPFYSTELNKPAMIYCSHGDGHWVHAQCMDLEERTLIHLSEGSNKYYCNEHVRIARALQTPKRNLPLQKPPMKSLHKKGSGKVLTPAKKSFLRRLFD
Protein: Meiotically up-regulated protein PB17E12.09 (Q8TFH5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis and sporulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Note=Localizes at the barrier septum and the cell tip.
Interaction partners:
- Meiotically up-regulated gene 131 protein
- Meiotic expression up-regulated protein 6
Sequence:
MQDRFLKENTEIINLSSSIHPNRDSYLDSQSDPLNQNLYNIETENVKDLNIEDVDYYEKLQNFKIVDENIDPGLRTYSKRSVGVNNTFQNPCNRKIEGYIKEIERLSNSNKNLQAAVLQMAVSDTDDPRLKEEYKQTEKELLREISGNHKSKILKLEEELNDLKHSMKEMQLYMTKIIDKAMNNASLENLFSLDENNTKIHDK
Protein: Glutathione/L-cysteine transport system ATP-binding/permease protein CydD (EC 7.4.2.-) (P29018)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex CydDC that exports the reduced low-molecular-weight thiols cysteine and glutathione to the periplasm. Export of these thiol-containing redox-active molecules may be crucial for redox homeostasis in the periplasm, permitting correct assembly of various respiratory complexes and formation of correct disulfide bonds in periplasmic and secreted proteins (Probable). CydD contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Required for the assembly of functional cytochrome bd-type quinol oxidases and periplasmic c-type cytochromes. Overexpression of CydDC under anaerobic conditions also results in the formation of a heme biosynthesis-derived pigment, P-574. CydDC binds heme b, but heme is probably not transported by the complex and instead has a role in regulating ATPase activity.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15470119, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15470119}.
Interaction partners:
- Glutathione/L-cysteine transport system ATP-binding/permease protein CydC
- Cytochrome bd-I ubiquinol oxidase subunit 2
- Cytochrome bd-I ubiquinol oxidase subunit 1
- Methionine import ATP-binding protein MetN
- Phosphate import ATP-binding protein PstB
- L-cystine transport system ATP-binding protein TcyN
- Uncharacterized amino-acid ABC transporter ATP-binding protein YhdZ
- Glutamine transport ATP-binding protein GlnQ
- Iron
- Cytochrome bd-II ubiquinol oxidase subunit 2
Sequence:
MNKSRQKELTRWLKQQSVISQRWLNISRLLGFVSGILIIAQAWFMARILQHMIMENIPREALLLPFTLLVLTFVLRAWVVWLRERVGYHAGQHIRFAIRRQVLDRLQQAGPAWIQGKPAGSWATLVLEQIDDMHDYYARYLPQMALAVSVPLLIVVAIFPSNWAAALILLGTAPLIPLFMALVGMGAADANRRNFLALARLSGHFLDRLRGMETLRIFGRGEAEIESIRSASEDFRQRTMEVLRLAFLSSGILEFFTSLSIALVAVYFGFSYLGELDFGHYDTGVTLAAGFLALILAPEFFQPLRDLGTFYHAKAQAVGAADSLKTFMETPLAHPQRGEAELASTDPVTIEAEELFITSPEGKTLAGPLNFTLPAGQRAVLVGRSGSGKSSLLNALSGFLSYQGSLRINGIELRDLSPESWRKHLSWVGQNPQLPAATLRDNVLLARPDASEQELQAALDNAWVSEFLPLLPQGVDTPVGDQAARLSVGQAQRVAVARALLNPCSLLLLDEPAASLDAHSEQRVMEALNAASLRQTTLMVTHQLEDLADWDVIWVMQDGRIIEQGRYAELSVAGGPFATLLAHRQEEI
Protein: Cytochrome c551 (D0VWQ8)
Organism: Alcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans)
Interaction partners:
Sequence:
AADAPAQLDPAGEKLYRSACVVCHASGVANAPKLGDKQAWAPFLAQGADALLATVLKGKGAMPPRGGTAADEATLRAAVAYMMDAAR
Protein: Putative RRM-containing protein (Putative splicing regulatory protein) (RNA-binding (RRM/RBD/RNP motifs) family protein) (Q8LA96)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g58750
- Putative RING zinc finger protein; 84572-85321
- Small COPII coat GTPase SAR1B
- At4g25680
- At4g25660
- AT3g07170/T1B9_17
- Uncharacterized protein At2g34160
- Ras-related protein RABE1c
- Gamma carbonic anhydrase 2, mitochondrial
- Ras-related protein RABD1
Sequence:
MTMTTVKVSNVSLGATDRDLKEFFSFSGDILYLETQSETERTKLAYVTFKDLQGAETAVLLSGATIVDSSVIVSMAPDYQLSPEALASLEPKDSNKSPKAGDSVLRKAEDVVSSMLAKGFILGKDAIAKAKSVDEKHQLTSTASAKVASFDKKIGFTDKINTGTVVVGEKVREVDQKYQVSEKTKSAIAAAEQTVSNAGSAIMKNRYVLTGATWVTGAFNKVAKAAEEVGQKAKEKVGMAEEEDKRKVVDEFARVHLSESPKAASSTQEAERESKLSESPEAKKDSEHLEPQSKPLQQQSPPPMASAPAPAQP
Protein: LIM and calponin homology domains-containing protein 1 (Q9UPQ0)
Organism: Homo sapiens (Human)
Function: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.
Subcellular location: Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:28228547}.
Interaction partners:
Sequence:
MACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNIILFLRGCKELGLKESQLFDPSDLQDTSNRVTVKSLDYSRKLKNVLVTIYWLGKAANSCTSYSGTTLNLKEFEGLLAQMRKDTDDIESPKRSIRDSGYIDCWDSERSDSLSPPRHGRDDSFDSLDSFGSRSRQTPSPDVVLRGSSDGRGSDSESDLPHRKLPDVKKDDMSARRTSHGEPKSAVPFNQYLPNKSNQTAYVPAPLRKKKAEREEYRKSWSTATSPLGGERPFRYGPRTPVSDDAESTSMFDMRCEEEAAVQPHSRARQEQLQLINNQLREEDDKWQDDLARWKSRRRSVSQDLIKKEEERKKMEKLLAGEDGTSERRKSIKTYREIVQEKERRERELHEAYKNARSQEEAEGILQQYIERFTISEAVLERLEMPKILERSHSTEPNLSSFLNDPNPMKYLRQQSLPPPKFTATVETTIARASVLDTSMSAGSGSPSKTVTPKAVPMLTPKPYSQPKNSQDVLKTFKVDGKVSVNGETVHREEEKERECPTVAPAHSLTKSQMFEGVARVHGSPLELKQDNGSIEINIKKPNSVPQELAATTEKTEPNSQEDKNDGGKSRKGNIELASSEPQHFTTTVTRCSPTVAFVEFPSSPQLKNDVSEEKDQKKPENEMSGKVELVLSQKVVKPKSPEPEATLTFPFLDKMPEANQLHLPNLNSQVDSPSSEKSPVMTPQFKFWAWDPEEERRRQEKWQQEQERLLQERYQKEQDKLKEEWEKAQKEVEEEERRYYEEERKIIEDTVVPFTVSSSSADQLSTSSSMTEGSGTMNKIDLGNCQDEKQDRRWKKSFQGDDSDLLLKTRESDRLEEKGSLTEGALAHSGNPVSKGVHEDHQLDTEAGAPHCGTNPQLAQDPSQNQQTSNPTHSSEDVKPKTLPLDKSINHQIESPSERRKKSPREHFQAGPFSPCSPTPPGQSPNRSISGKKLCSSCGLPLGKGAAMIIETLNLYFHIQCFRCGICKGQLGDAVSGTDVRIRNGLLNCNDCYMRSRSAGQPTTL
Protein: At1g01920 (SET domain-containing protein) (Q501D3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAISEEEAKLERFLDWLQVNGGELRGCNIKYSDSLKGFGIFASTSTQASDEVLLVVPLDLAITPMRVLQDPLLGPECQKMFEQGQVDDRFLMILFLTLERLRINSSWKPYLDMLPTRFGNPLWFSDDDILELKGTNLYHATELQKKKLLSLYHDKVEVLVTKLLILDGDSESKVSFEHFLWANSVFWSRALNIPLPHSFVFPQSQDDTGECTSTSESPETAPVNSNEEKEIQAQPAPSVGSGDTIWVEGLVPGIDFCNHDLKPVATWEVDGIGSVSRVPFSMYLLSVAQRPIPKKEISISYGNKGNEELLYLYGFVIDNNPDDYLMVHYPVEAIPSIPFSDSKGQLLEAQNAQLRCLLPKSVLNHGFFPRTTSVIRESDEKETVRSCNFSWSGKRKMPTYMNKLVFPEDFMTGLRTIAMQEEEIYKVSAMLEELVESRQGEQPSETEVRMAVWEACGDSGALQLLVDLLNSKMMKLEENSGTEEQDARLLEEACVLESHEESRDLDGRRMSRNKWSSVVYRRGQKQLTRLLLKEAEHALHLALSSDH
Protein: RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) (O60306)
Organism: Homo sapiens (Human)
Function: Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro).
Subcellular location: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16949364}. Note=Localizes to speckle-like regions of the nucleoplasm. {ECO:0000269|PubMed:16949364}.
Interaction partners:
- Peptidyl-prolyl cis-trans isomerase E
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor RBM22
- Cell division cycle 5-like protein
- Pre-mRNA-splicing factor SPF27
- Pre-mRNA-processing factor 19
- Pre-mRNA-processing factor 17
- 116 kDa U5 small nuclear ribonucleoprotein component
- Pre-mRNA-processing-splicing factor 8
- Crooked neck-like protein 1
Sequence:
MAAPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIKVIEDIYEKEIVKSRFAIRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWEIFKKKPDHFPFFFKHILKAALAETDGEFSLHEQTVLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQLARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQERRFLSQLIQKFISVLKSVPLSEPVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDDSHLLVHCYLSNLVRREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEVDTRESLVKFFGPLSSNTLHQVASYLCLLPTLPKNEDTTFDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVEVAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFIEQVGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYETFNIIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLSIEHLKASFPGHNVKVTVEDPALQIPPFRITFPVRSGKGKKRKDADVEDEDTEEAKTLIVEPHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYISKVKNKGSTLPDVTEVSTFFPFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNLYNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLHIIPTEPFPTTRKNGERPSHEVQIIKNMPQMANFVYNMYMHLIQTTHHYHQTLLQLPPAMVEEGEEVQNQETELETEEEAMTVQADIIPSPTDTSCRQETPAFQTDTTPSETGATSTPEAIPALSETTPTVVGAVSAPAEANTPQDATSAPEETK
Protein: Isoflavone reductase homolog A622 (NtA622) (EC 1.3.1.-) (P52579)
Organism: Nicotiana tabacum (Common tobacco)
Function: Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN). Probable NADPH-dependent oxidoreductase that binds NADPH in vitro. Does not seem to be involved in the NADPH-dependent reduction of phenylcoumaran benzylic ethers. Reductase that may be involved in a late step of tobacco alkaloid biosynthesis. Maybe involved in either the formation of a nicotinic acid-derived precursor or the final condensation reaction of tobacco alkaloids.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P52580}.
Interaction partners:
- Quinolinate phosphoribosyltransferase [decarboxylating] 2a, mitochondrial
- Protein DETOXIFICATION
Sequence:
MVVSEKSKILIIGGTGYIGKYLVETSAKSGHPTFALIRESTLKNPEKSKLIDTFKSYGVTLLFGDISNQESLLKAIKQVDVVISTVGGQQFTDQVNIIKAIKEAGNIKRFLPSEFGFDVDHARAIEPAASLFALKVRIRRMIEAEGIPYTYVICNWFADFFLPNLGQLEAKTPPRDKVVIFGDGNPKAIYVKEEDIATYTIEAVDDPRTLNKTLHMRPPANILSFNEIVSLWEDKIGKTLEKLYLSEEDILQIVQEGPLPLRTNLAICHSVFVNGDSANFEVQPPTGVEATELYPKVKYTTVDEFYNKFV