Protein: Integrin beta-PS (Position-specific antigen beta subunit) (Protein myospheroid) (Protein olfactory C) (P11584)
Organism: Drosophila melanogaster (Fruit fly)
Function: Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development). Involved in the function and/or development of the olfactory system. In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip. Plays a role in timely border cell migration during oogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:38283991}; Single-pass type I membrane protein {ECO:0000269|PubMed:19035354}. Apical cell membrane {ECO:0000269|PubMed:19035354}; Single-pass type I membrane protein {ECO:0000269|PubMed:19035354}. Lateral cell membrane {ECO:0000269|PubMed:19035354}; Single-pass type I membrane protein {ECO:0000269|PubMed:19035354}. Basal cell membrane {ECO:0000269|PubMed:19035354}; Single-pass type I membrane protein {ECO:0000269|PubMed:19035354}. Note=In ovary, localizes to the apical, lateral and basal membranes of follicle cells through oogenesis stage 10A (PubMed:19035354). Apical membrane expression peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte but decreases in the most posterior follicle cells (PubMed:19035354). Thereafter, it is down-regulated. Localization to lateral and basal membranes persists during dorsal appendage morphogenesis (PubMed:19035354). Localizes to the cell membrane of migrating border cell clusters during stage 9-10 of oogenesis; cell surface localization is dependent on Aldo-keto reductase 1B (Akr1B) and may play a role in cluster morphology (PubMed:38283991). {ECO:0000269|PubMed:19035354, ECO:0000269|PubMed:38283991}.
Interaction partners:
- Integrin alpha-PS3
- Integrin alpha-PS1
- Integrin linked kinase, isoform A
- Integrin alpha-PS4
- Integrin alpha-PS5
- Integrin alpha-PS2
- Rhea, isoform B
- Viking, isoform A
- Laminin subunit alpha
- Laminin subunit gamma-1
Sequence:
MILERNRRCQLALLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTEGCAWCMQPDFKGQSRCYQNTSSLCPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCENCKAPYGYQNHMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGDVKITYFSSCLSNGPEVQTSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQGELHVYAQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFKNPMYAGK