wanglab/gogpt-training-data huggingface dataset:
Protein: Oxidative and nitrosative stress transcriptional dual regulator (Q88C74)
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Interaction partners:
- Alkyl hydroperoxide reductase subunit F
- Redox-sensitive transcriptional activator SoxR
- Catalase-peroxidase
- ATP-dependent DNA helicase RecG
- Superoxide dismutase
- Catalase
- Alkyl hydroperoxide reductase C
- Superoxide dismutase
Sequence:
MTLTELRYIVTLAQEQHFGHAAERCHVSQPTLSVGVKKLEDELGVLIFERSKSAVRLTPVGENIVAQAQKVLEQAQGIRELAQAGKNQLTAPLKVGAIYTVGPYLFPHLIPQLHRVAPQMPLYIEENFTHVLREKLRNGELDAVIIALPFNEADVLTLPLYDEPFCALMPADHPWTAKKTIDTAMLNDKSLLLLGEGHCFRDQVLEACPTLNKGGEGSRHTTVESSSLETIRHMVASGLGVSILPLSAVHSHHYAPGVIEVRPLTAPAPFRTVAIAWRASFPRPKAIEILADSIRLCSVAKNPAEQPA
Protein: Glypican 6 (A0A096MJY1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004471}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004471}; Extracellular side {ECO:0000256|ARBA:ARBA00004471}.
Interaction partners:
- Syndecan-2
- Glypican 4
- Syndecan-3
- Syndecan-1
- Sulfotransferase
Sequence:
MPSWIRAVILPLSGLLLTLPAAADVKARSCSEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSTLPYTICKDERVTAGTSNDEECWNGHSKARYLPEIMNDGLTNQINNPEVEVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREEESSASKLSSSLISWSLVCVVLALQRLNR
Protein: CNK3/IPCEF1 fusion protein (G9CGD6)
Organism: Homo sapiens (Human)
Function: Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration.
Interaction partners:
- Interaction protein for cytohesin exchange factors 1
- Cytohesin-2
Sequence:
MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKAFVSTKMTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI
Protein: Uncharacterized protein (Q38D56)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHCRLLATNIPLHITAEEFYDYVRAHSSGDAVVNALLITRPGDNGAAAPGIRKGPAKRKRAAENPFVSSGAALIDYETKAAADAARRVDFLVGDTVVMLNVVGSVAVSGQRECEKEGRKAYEQLRCGIRDDNFDSAGGRKRPPPNVEAAVHEMEVRLVGIPTHLYGNFLGGIGEIVRKEGPRGEEEVGGSDPSVARFGSAVVLRSVADLFFDVALAIRHLTMGEMLSLRRVCDDEALITVPRAVGIRLLELASEGHGLQVTVAVGEEEQNGWKVTEQSQCVSYYLSVHKPRAQVMVDGENLQLVKKHEVLRSMANMMEHTNAKVAGFVDPFGNVLIPRQ
Protein: Extracellular sulfatase SULF-1 homolog (DmSulf-1) (EC 3.1.6.-) (Q9VEX0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Cell surface {ECO:0000250}. Note=Also localized on the cell surface. {ECO:0000250}.
Interaction partners:
- Heparan-sulfate 6-O-sulfotransferase
- Heparin sulfate O-sulfotransferase
- heparosan-N-sulfate-glucuronate 5-epimerase
- Division abnormally delayed protein
- GH20068p
- Dally-like, isoform A
- Heparan sulfate 3-O sulfotransferase-B, isoform A
- Exostosin-2
Sequence:
MMRHSSLRLIIGGLILLLFVLNVFSKEQGSHSHKRSHSAKRFSRDSNSARERRPNIILILTDDQDVELGSLNFMPRTLRLLRDGGAEFRHAYTTTPMCCPARSSLLTGMYVHNHMVFTNNDNCSSPQWQATHETRSYATYLSNAGYRTGYFGKYLNKYNGSYIPPGWREWGGLIMNSKYYNYSINLNGQKIKHGFDYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLLTMSFPAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQPVHKRFTNLLMTKRLQTLQSVDVAVERVYNELKELGELDNTYIVYTSDHGYHLGQFGLIKGKSFPFEFDVRVPFLIRGPGIQASKVVNEIVLNVDLAPTFLDMGGVPTPQHMDGRSILPLLLSRNRAVRDNWPDSFLIESSGRRETAEQIAESRARLQIERRNMKLANSSLLEDFLEGAGESTTIVSSSSTAATLMSSTAQQPEDGEEEVETDNEEDDVDGDGAMDSSAAALEEDDLDDAAFEEGDEELDQEFQQNNDLPLAPYITKMMRLNSECSDPALLKNCLPGQKWKCVNEEGRWRKHKCKFHLQLEHQLAAMPRKQYQRNCACFTPDGVVYTKIRAPSAGLHRVNKRTHNGPGRRRNKREVFHTELPDEMEELLDLHQVVDQLVDHTHRSKRDLPASSNETIAQVIQQIQSTLEILELKFNEHELHASNSSGNSYERGEKYTKSGGHRCFVDATTAKVNCSNVIYDDEKTWRTSRTQIDMLIKLLKDKIGKLKEMKKQLRESNKQALAAGRRNDNRRRNDQSVLDSGAGPEFNMSYFTEISSTPRSNVVGQTEVFQGYGSASAFDSLEQTQSHRFTPRAECYCEPDVGENHADSKEMAREARRKLKEERQRKKERKRIKKARLEKECLSEKMNCFSHDNQHWRTAPLWNDSPFCFCMNANNNTYSCLRTINGTHNFLYCEFTTGLITFYNLTIDRFETINRAAGLTPGERSHMHDALDQLKSCRGRSCSIRRHQNHLEGGSSAPLLPINQVHRNNKRKHSPLAGAVGNYAFVGPRLDMEALPPIKRRKLSKYNRLTGSQQSHMKRRPWKQTPLQQSPRFLRTHSVTPAQA
Protein: DNA utilization protein HofO (P45751)
Organism: Escherichia coli (strain K12)
Function: Required for the use of extracellular DNA as a nutrient.
Subcellular location: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- DNA utilization protein HofN
- DNA utilization protein HofP
- DNA utilization protein HofM
- DNA utilization protein HofQ
Sequence:
MNMFFDWWFATSPRLRQLCWAFWLLMLVTLIFLSSTHHEERDALIRLRASHHQQWAALYRLVDTAPFSEEKTLPFSPLDFQLSGAQLVSWHPSAQGGELALKTLWEAVPSAFTRLAERNVSVSRFSLSVEGDDLLFTLQLETPHEG
Protein: Chlorophyll a-b binding protein CP29.1, chloroplastic (LHCB4.1) (LHCII protein 4.1) (Q07473)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular location: Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Interaction partners:
- Chlorophyll a-b binding protein CP26, chloroplastic
- Photosystem II CP43 reaction center protein
- Photosystem II CP47 reaction center protein
- Photosystem II protein D1
- Chlorophyll a-b binding protein 1, chloroplastic
- Photosystem II reaction center protein H
- Photosystem II D2 protein
- Chlorophyll a-b binding protein 2, chloroplastic
- Chlorophyll a-b binding protein
- Oxygen-evolving enhancer protein 1-1, chloroplastic
Sequence:
MAATSAAAAAASSIMGTRVAPGIHPGSGRFTAVFGFGKKKAAPKKSAKKTVTTDRPLWYPGAISPDWLDGSLVGDYGFDPFGLGKPAEYLQFDIDSLDQNLAKNLAGDVIGTRTEAADAKSTPFQPYSEVFGIQRFRECELIHGRWAMLATLGALSVEWLTGVTWQDAGKVELVDGSSYLGQPLPFSISTLIWIEVLVIGYIEFQRNAELDSEKRLYPGGKFFDPLGLAADPEKTAQLQLAEIKHARLAMVAFLGFAVQAAATGKGPLNNWATHLSDPLHTTIIDTFSSS
Protein: Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (WT1-associated protein) (Wilms tumor 1-associating protein) (Q7SXL7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.
Subcellular location: Nucleus speckle {ECO:0000250|UniProtKB:Q15007}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q15007}.
Interaction partners:
- Protein virilizer homolog isoform X2
- RNA-binding protein 15
- Zinc finger CCCH domain-containing protein 13
- N
- N
- RNA demethylase ALKBH5
- Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase.
- RNA N
- RNA-binding motif protein 15B.
- YTH domain-containing family protein
Sequence:
MTNEEPLPKKVRLSESDMKTLTREELCTRWKQHETYVQMLEAKYADLNSNDVTGLKESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSAAQLRSSMVDPAINLFFLKMKAELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLRETRQQLSQMNQTQGTSSGAGPSRTSPSTASEPSTQSEPANASSSNVGKDCGRVSNGPSNGNSSQRGASGSSLYREASSADEDYPPSPSVSSPTHDGISKLSNHSEDAVSQRGGEGYVTQLSAGYESVDSPTGSETSVTQHSNDTDSNADSHEAAAVPKGSRTAGTRHSTQNGLDSSAAAVATNTSNASAGSVL
Protein: Synaptotagmin-6 (Synaptotagmin VI) (SytVI) (Q62746)
Organism: Rattus norvegicus (Rat)
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9R0N8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N8}.; SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000250|UniProtKB:Q9R0N8}; Single-pass membrane protein {ECO:0000250}. Note=Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (By similarity). {ECO:0000250|UniProtKB:Q9R0N8}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9R0N8}. Cell membrane {ECO:0000250|UniProtKB:Q9R0N8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9R0N8}.
Interaction partners:
Sequence:
MSGVWGAGGPRCQAALAVLASLCRARPPPLGLDVETCQSFELQPPEQSPSAADSGTSVSLLAVVVIVCGVALVAVFFFLFWKLCWMPWRNKEASSPSSANPASEILQSPSSRGNMADKLKDPSALGFLEAAVKISHTSPDIPAEVQMSVKEHIMRHTKLQRQTTEPASSTRHTSFKRHLPRQMHVSSVDYGNELPPAAAEQPTSIGRIKPELYKQKSVDGDEAKSEAAKSCGKINFSLRYDYESETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGISAEGLGRDHWNEMLAYPRKPIAHWHCLAEVKKSFKEGTPRL
Protein: Probable peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29) (O74806)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P38876}.
Interaction partners:
- Meiotically up-regulated gene 82 protein
- Cytochrome c oxidase subunit 4, mitochondrial
- Uncharacterized GTP-binding protein P8A3.11c
Sequence:
MAIKHLPKILIARKNKAEVNHCDLKRRVSIKIIYGLGNPGSAFVKSRHSLGKLMVSMYADSMAFPKNWPSTKENLTLVLSTSYMNDSGKQLKKISNDFVRKVSPLDKIVYVVVHDELELDLGKVKLRLPGGSHRGHNGIRSCQEFLGKESFYRIGLGIGRCESRNREDVSDYVLSKFNSNEMKLIETDIFHKFCNILQQLQLSIET
Protein: Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (Mitochondrial translocator assembly and maintenance protein 41 homolog) (TAM41) (Q96BW9)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:D3ZKT0}; Peripheral membrane protein {ECO:0000250|UniProtKB:D3ZKT0}; Matrix side {ECO:0000250|UniProtKB:P53230}.
Interaction partners:
- Phosphatidate cytidylyltransferase 1
- Phosphatidate cytidylyltransferase 2
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
- Tafazzin
- PRELI domain-containing protein 1, mitochondrial
Sequence:
MALQTLQSSWVTFRKILSHFPEELSLAFVYGSGVYRQAGPSSDQKNAMLDFVFTVDDPVAWHSKNLKKNWSHYSFLKVLGPKIITSIQNNYGAGVYYNSLIMCNGRLIKYGVISTNVLIEDLLNWNNLYIAGRLQKPVKIISVNEDVTLRSALDRNLKSAVTAAFLMLPESFSEEDLFIEIAGLSYSGDFRMVVGEDKTKVLNIVKPNIAHFRELYGSILQENPQVVYKSQQGWLEIDKSPEGQFTQLMTLPKTLQQQINHIMDPPGKNRDVEETLFQVAHDPDCGDVVRLGLSAIVRPSSIRQSTKGIFTAGKSFGNPCVTYLLTEWLPHSWLQCKALYLLGACEMLSFDGHKLGYCSKVQTGITAAEPGGRTMSDHWQCCWKLYCPSEFSETLPVCRVFPSYCFIYQSYRCIGLQKQQHLCSPSSSPSLRQLLPSVLVGYFCCYCHFSKW
Protein: Glypican-1 [Cleaved into: Secreted glypican-1] (P35052)
Organism: Homo sapiens (Human)
Function: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP amyloid-beta peptides in lipid rafts in Alzheimer disease brains.; SUBCELLULAR LOCATION: [Secreted glypican-1]: Secreted, extracellular space.
Interaction partners:
- Syndecan-1
- Syndecan-2
- Fibroblast growth factor 2
- Syndecan-4
- Proheparin-binding EGF-like growth factor
- Collagen alpha-1
- Slit homolog 2 protein
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Slit homolog 3 protein
- CD44 antigen
Sequence:
MELRARGWWLLCAAAALVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRWR
Protein: Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 (EC 2.4.1.15) (Trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (Q00075)
Organism: Aspergillus niger
Function: Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process.
Interaction partners:
Sequence:
MPSLENPTFQNEARLLLVSNRLPITIKRSDDGRYDFSMSSGGLVSGLSGLSKSTTFQWYGWPGLEVPEEEIPVVKERLKQEYNAVPVFIDDELADRHYNGFSNSILWPLFHYHPGEITFDESAWEAYKEANRLFAKAVAKEVQDGDLIWVHDYHLMLLPEMLREEIGDSKENVKIGFFLHTPFPSSEIYRILPVRNELLLGVLHCDLIGFHTYDYTRHFLSACSRLLGLTTTPNGIEFQGKIIACGAFPIGIDPEKFEEGLKKEKVQKRIAMLEQKFQGVKLMVGVDRLDYIKGVPQKLHALEVFLSDHPEWVGKVVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGKFGTVEFMPIHFLHKSVNFDELIALYAVSDACIVSSTRDGMNLVAYEYIATQKKRHGVLVLSEFAGAAQSLNGSIIINPWNTEELAGAYQEAVTMSDEQRALNFSKLDKYVNKYTSAFWGQSFVTELTRISEHSAEKFHAKKASFSDNNSENGEPSNGVETPAQEQVAQ
Protein: Myotubularin related protein 4 (A0A8I6GD39)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRAADALIAISNYRLHIKFKDSVINVPLRMIDSVESRDMFQLHIACKDSKVVR
Protein: Palustrin-3a (P84281)
Organism: Lithobates palustris (Pickerel frog) (Rana palustris)
Function: Antimicrobial activity against Gram-negative bacterium E.coli.
Subcellular location: Secreted {ECO:0000269|PubMed:11087945}.
Interaction partners:
Sequence:
GIFPKIIGKGIKTGIVNGIKSLVKGVGMKVFKAGLNNIGNTGCNEDEC
Protein: FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) (Q9Y5B9)
Organism: Homo sapiens (Human)
Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
Subcellular location: Nucleus {ECO:0000269|PubMed:10421373}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Interaction partners:
- FACT complex subunit SSRP1
- Transcription elongation factor SPT5
- RNA polymerase-associated protein LEO1
- RNA polymerase-associated protein CTR9 homolog
- RNA polymerase-associated protein RTF1 homolog
- Transcription elongation factor SPT6
- Parafibromin
- RNA polymerase II-associated factor 1 homolog
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB1
Sequence:
MAVTLDKDAYYRRVKRLYSNWRKGEDEYANVDAIVVSVGVDEEIVYAKSTALQTWLFGYELTDTIMVFCDDKIIFMASKKKVEFLKQIANTKGNENANGAPAITLLIREKNESNKSSFDKMIEAIKESKNGKKIGVFSKDKFPGEFMKSWNDCLNKEGFDKIDISAVVAYTIAVKEDGELNLMKKAASITSEVFNKFFKERVMEIVDADEKVRHSKLAESVEKAIEEKKYLAGADPSTVEMCYPPIIQSGGNYNLKFSVVSDKNHMHFGAITCAMGIRFKSYCSNLVRTLMVDPSQEVQENYNFLLQLQEELLKELRHGVKICDVYNAVMDVVKKQKPELLNKITKNLGFGMGIEFREGSLVINSKNQYKLKKGMVFSINLGFSDLTNKEGKKPEEKTYALFIGDTVLVDEDGPATVLTSVKKKVKNVGIFLKNEDEEEEEEEKDEAEDLLGRGSRAALLTERTRNEMTAEEKRRAHQKELAAQLNEEAKRRLTEQKGEQQIQKARKSNVSYKNPSLMPKEPHIREMKIYIDKKYETVIMPVFGIATPFHIATIKNISMSVEGDYTYLRINFYCPGSALGRNEGNIFPNPEATFVKEITYRASNIKAPGEQTVPALNLQNAFRIIKEVQKRYKTREAEEKEKEGIVKQDSLVINLNRSNPKLKDLYIRPNIAQKRMQGSLEAHVNGFRFTSVRGDKVDILYNNIKHALFQPCDGEMIIVLHFHLKNAIMFGKKRHTDVQFYTEVGEITTDLGKHQHMHDRDDLYAEQMEREMRHKLKTAFKNFIEKVEALTKEELEFEVPFRDLGFNGAPYRSTCLLQPTSSALVNATEWPPFVVTLDEVELIHFERVQFHLKNFDMVIVYKDYSKKVTMINAIPVASLDPIKEWLNSCDLKYTEGVQSLNWTKIMKTIVDDPEGFFEQGGWSFLEPEGEGSDAEEGDSESEIEDETFNPSEDDYEEEEEDSDEDYSSEAEESDYSKESLGSEEESGKDWDELEEEARKADRESRYEEEEEQSRSMSRKRKASVHSSGRGSNRGSRHSSAPPKKKRK
Protein: Cytochrome b5 type B (Q6NY41)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- NADH-cytochrome b5 reductase
- NADH-cytochrome b5 reductase
- NADH-cytochrome b5 reductase 2
- Membrane-associated progesterone receptor component 1
- Neuferricin
- Membrane-associated progesterone receptor component 2
- Acylaminoacyl-peptide hydrolase.
- Cytochrome b5 reductase 4
- Lanosterol 14-alpha demethylase
- Adrenodoxin, mitochondrial
Sequence:
MGEETGSSVGRENQNTKNESTQEDSGVKYYTRKEVQVHNMGKDTWLIIHDKVYDITSFMEEHPGGEEVLLEQAGADATESFEDVGHSTDAREMLQQYYIGELHMDDRKKESKKEVYITTSKDSRSWSTWFIPAIAAVLVGIMYRYYTLEHKSS
Protein: Coiled-coil domain containing 24 (F6ZQN5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
NVSNIDQVVRHLRSLLEEECHMLQNEISDLQHCLEMEQMQACQPSKDTQMPTLGEIKDQKAAMERELQVSLGPSCTAAKHRYTKTDTGWAM
Protein: Polymer-forming cytoskeletal family protein (O26067)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- Flagellar motor switch protein FliN
- ToxR-activated gene
- ToxR-activated gene
- Leucine--tRNA ligase
- Protein translocase subunit SecF
- Protein translocase subunit SecD
- Dihydrofolate synthase/folylpolyglutamate synthase
- Transcription-repair-coupling factor
- Lipoprotein
- Conserved hypothetical integral membrane protein
Sequence:
MAIFDNNNKSANAKTGPATIIAQGTKIKGELHLDYHLHVDGELEGVVHSKSTVVIGQTGSVVGEIFTNKLVVSGKFTGTVEAEVVEIMPLGHLDGKISSQELVVERKGILIGETRPKNIQGGALLINEQEKKIENK
Protein: 5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73) (Q05927)
Organism: Bos taurus (Bovine)
Function: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate. Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms (By similarity). Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:8340354}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:8340354}.
Interaction partners:
- Adenosine deaminase
- Uridine phosphorylase
- Uridine phosphorylase
- NAD-capped RNA hydrolase NUDT12
- Ectonucleoside triphosphate diphosphohydrolase 1
- Purine nucleoside phosphorylase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Sequence:
MNPGAARTPALRILALGALLWPAARPWELTILHTNDVHSRLEQTSEDSSKCVNASRCVGGVARLATKVHQIRRAEPHVLLLDAGDQYQGTIWFTVYKGTEVAHFMNALGYDAMALGNHEFDNGVEGLIDPLLKEVNFPILSANIKAKGPLASKISGLYSPYKILTVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEVDKLIAQKVKGVDVVVGGHSNTFLYTGNPPSKEVPAGQYPFIVTSDDGRKVPVVQAYAFGKYLGYLKVEFDEKGNVVTSHGNPILLNSSIPEDPNIKADINKWRVKLDNYSTQELGKTIVYLDGTAQSCRFRECNMGNLICDAMINNNLRHPDEMSWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQATGEFLQVGGIHVVYDISRNPGDRVVKLEVLCTQCRVPSYEPLRMDKVYKVILPSFLVSGGDGFQMIKDEKIKHDSGDQDINVVSGYISKMKVLYPAVEGRIQFSAGSHCCGSFSLIFLSVLAVIIILYQ
Protein: Pleckstrin homology domain-containing family G member 5 isoform X1 (Pleckstrin homology domain-containing, family G (with RhoGef domain) member 5a) (F1R1Q2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MFYWRRHGSYELETLPCAQSEFGVEKYTWTSLMDITQKACGEKPAPEQKPGLLCQHPNCPEQRLASKVCHHPSCQDLRDGSPLHLCESCDSICHPAAHDGMIFDRHPRFDLQPQGSILARNVSTRSCPPRTGPPSDMEDGEDGCSDLGDRRSGGMKLVKKKTRRRHTDDPSKECFTLKFDLNFEVSMEIVPAVKKKTLREVLGAVFERKGIELSRVNLFLDQSNTPLSLGFEAYRFGGHYLRVRARPGEDLRVERCVKDPRSLSLPIMRSSSNTHSSSTDRAEHGSLGRREAADLLVGLVGHAAYIQKNGGQTRRRKNMPEFLGDSSISNQDSLSQLSGSLPGSITGPDRWRNRAASRFSGLFSSNSGNGSLGKECDRVEQLQSKLYSYTMFGLPKMPPQLSFHRDSWEEEPNLELEESWKQLLENPEILTRRQCHQQEAIWELLQTESDYIKKLHVITDLFLCGLLNLQESGLLTEVEPTRLFSNIQDIVQLHSSLWTEVMLPALEKARQKRTMLNPTELHQGFSTFGFRFKPYIRYCMEEEGCMEYMRTLLKDNELFRIYVTWAETHKQCNRLKLTDMLVKPHQRLTKYPLLLKSVLKKTDDPPTREAINRMVAAVECFINSVDSQMRHREEKQKLAAIAGRIEAYEAVEGASEEVERILKEYNNFDLMAPVMGAPPEETRQLLLEGALKMKEGKESRMDVYCFLFTDVLLITKPVKRVEKVKVIRQPLVIHNVVCRELKDPGSFLLIYLNEFGCAVASYCFQANSGAQGRSWIEAIYNAQNQLQRLRSETQRDESDEKDEDETESSMSTSSSPSIHHRETLSKSLSLSPSHSDGSTETLSVAAMDEVDEVVGSTVQTASMRNSLLSDDSFSTSDSKTLQALGDLIVTDLDPESRSLSIDSAYGTLSPQSMITELDLKGGVCQSEGEETDAGEEEEAFEDDEDDDDDGDDSITWNGSQITVNESYILDTNSEELNRRNDFSGMAQVVAGCRSQTLRRRSPVQPRPDYLQHFTLRSRSEDDLLQCLTDPLLLRPTGKNNVSKSLTHLAKQKSHSDEVFQTDEDELLEDAKTLSSKLSNTLQRAEARQVQRTLSCPNGQADSEGSDAETAPPGGMEEKKDLVVVQQTHQQHKKLTVAQLHKIRATMVLNSTLTASEV
Protein: Actin depolymerizing factor 3 (A1XJ46)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MANAASGMAVHDDCKLKFLELKTKRTHRFIVFKIEEKQKQVIVEKLGEPTESYEDFTKCLPADECRYAVYDFDFLTAENVPKSRIFFIAWSPDTSRIRSKMIYASSKDRFKRELDGIQVELQATDPTEMGLDVFKSRAN
Protein: Lens fiber major intrinsic protein (Aquaporin-0) (MIP26) (MP26) (P06624)
Organism: Bos taurus (Bovine)
Function: Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23893133}; Multi-pass membrane protein {ECO:0000269|PubMed:15377788, ECO:0000269|PubMed:16309700}. Cell junction {ECO:0000250|UniProtKB:Q6J8I9}. Note=Localizes to thin cell-cell junctions in lens fiber cells. {ECO:0000250|UniProtKB:Q6J8I9}.
Interaction partners:
- Calmodulin
- EF-hand calcium-binding domain-containing protein 11
- Filensin
- Aquaporin 10
- Lens fiber membrane intrinsic protein
- Gamma-crystallin S
- Phakinin
- Beta-crystallin B2
- Beta-crystallin B1
- SPRY domain-containing protein 4
Sequence:
MWELRSASFWRAICAEFFASLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFPRLKSVSERLSILKGSRPSESNGQPEVTGEPVELKTQAL