wanglab/gogpt-training-data huggingface dataset:
Protein: Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide] (O35082)
Organism: Mus musculus (Mouse)
Function: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:12204354, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:9363890}; Single-pass type I membrane protein {ECO:0000305|PubMed:9363890}. Apical cell membrane {ECO:0000269|PubMed:15665504}; Single-pass type I membrane protein {ECO:0000305|PubMed:15665504}. Note=Isoform 1 shedding leads to a soluble peptide. {ECO:0000269|PubMed:16123266}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:15135068}.; SUBCELLULAR LOCATION: [Klotho peptide]: Secreted {ECO:0000269|PubMed:16123266}.
Interaction partners:
- Fibroblast growth factor receptor 1
- Fibroblast growth factor 23
- Fibroblast growth factor receptor 4
- Fibroblast growth factor receptor 3
- Fibroblast growth factor 8
- Fibroblast growth factor 5
- Fibroblast growth factor 3
- Fibroblast growth factor 6
- Fibroblast growth factor 17
- Fibroblast growth factor 20
Sequence:
MLARAPPRRPPRLVLLRLLLLHLLLLALRARCLSAEPGQGAQTWARFARAPAPEAAGLLHDTFPDGFLWAVGSAAYQTEGGWRQHGKGASIWDTFTHHSGAAPSDSPIVVAPSGAPSPPLSSTGDVASDSYNNVYRDTEGLRELGVTHYRFSISWARVLPNGTAGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGRVSIALSSHWINPRRMTDYNIRECQKSLDFVLGWFAKPIFIDGDYPESMKNNLSSLLPDFTESEKRLIRGTADFFALSFGPTLSFQLLDPNMKFRQLESPNLRQLLSWIDLEYNHPPIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIRLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSSALFYQKLIEDNGFPPLPENQPLEGTFPCDFAWGVVDNYVQVDTTLSQFTDPNVYLWDVHHSKRLIKVDGVVAKKRKPYCVDFSAIRPQITLLREMRVTHFRFSLDWALILPLGNQTQVNHTVLHFYRCMISELVHANITPVVALWQPAAPHQGLPHALAKHGAWENPHTALAFADYANLCFKELGHWVNLWITMNEPNTRNMTYRAGHHLLRAHALAWHLYDDKFRAAQKGKISIALQADWIEPACPFSQNDKEVAERVLEFDIGWLAEPIFGSGDYPRVMRDWLNQKNNFLLPYFTEDEKKLVRGSFDFLAVSHYTTILVDWEKEDPMKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVLNWLRFKYGDLPMYVTANGIDDDPHAEQDSLRIYYIKNYVNEALKAYVLDDINLCGYFAYSLSDRSAPKSGFYRYAANQFEPKPSMKHYRKIIDSNGFLGSGTLGRFCPEEYTVCTECGFFQTRKSLLVFISFLVFTFIISLALIFHYSKKGQRSYK
Protein: Regulatory protein SUAPRGA1 (G5EB23)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Small ribosomal subunit protein mS29
- 37S ribosomal protein Rsm22
Sequence:
MLSLRTLTRTVPRTFSRSIATSSRSAILRPISNLPKTSFIQPSLKQAIRPSQAAFSTCKAFRQAEGDAELAAKLEDELKHEKSSGLEDLESSVQNIQYVLQNNSWEVKDVPGEQEVVLTKKFNDEEIRLTFTVADLQNLSEHEDLDALDELDYQGHQPVNQGGAGGFAQHPEDSVSPADRGEQDLEPSFPARVNVTIEKSGKGALLIQTVAQDGLFQVEEVSYFSKPDLAHAATAEKDWARQSLYAGPPFENLDEDLQTYLERYLEERGINAELANMIPDYIQVKEQKEYVRWLENVRNFVAA
Protein: Large ribosomal subunit protein eL24B (60S ribosomal protein L24-B) (L30) (RP29) (YL21) (P24000)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein eL19A
- Large ribosomal subunit protein uL18
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS12
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein eS21B
- Large ribosomal subunit protein uL23
Sequence:
MKVEVDSFSGAKIYPGRGTLFVRGDSKIFRFQNSKSASLFKQRKNPRRIAWTVLFRKHHKKGITEEVAKKRSRKTVKAQRPITGASLDLIKERRSLKPEVRKANREEKLKANKEKKRAEKAARKAEKAKSAGVQGSKVSKQQAKGAFQKVAATSR
Protein: Exocyst subunit Exo70 family protein (F4KG57)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Exocyst complex component SEC8
- Exocyst complex component SEC6
- Exocyst complex component SEC5A
- Exocyst complex component SEC5B
- Exocyst complex component SEC3A
- Exocyst complex component SEC15A
- Exocyst complex component SEC10a
- Exocyst complex component SEC10b
- Exocyst complex component SEC15B
- Exocyst complex component EXO84B
Sequence:
MGVAQAMEALTERASLMKESLHKSQTITDNMVGILGSFDHRLSALETAMRPTQIRTHSIRRAHENIDKALKAAEVILDQFDISRKAEAKILRGPHEDLESYLEAIDQLRGTIKFFSNNKMFKSASGVISHAHGLLSKALSKLEDEFRQILQNYSKPMEPDRLFECLPSNLRPSSEGEGGGGKTHDPHHKSLENAIFTVPTVIPPRVLPLLHDLAQQMVQAGHQQQLFKSYRDTRAAVLEQSLRKLGVERLSKDDVQRMQWEVLEAKIGNWIHYMRISVKLLFAAEKKICDQILDGVESLRDQCFGEVTVNSVAVLLSFGEAIAKSKRSPEKLFVLLDMYEIMRELQPEIELLFGSKPCAEMKESALNLTKRLAQTAQETFADFEEAVEKDATKTAVMDGTVHPLTSYVINYVKFLFDYQTTLRLLFQEFDSKDPDSELGAVTTRIMHALQNNLDGKSKQYKDVALTQLFLMNNVHYIVRSVRRSEAKDLLGDDWVQIHRRIVQQHANQYKRVSWAKILQCLTVQSSGSGPIENSNISRASVKDRFKTFNSQFEELHQRQCQWTVPDSELRESLRLAVAEVLLPAFRSFLKRFGPMIESGKNPQKYIRFSPEDLERMLNEFFEGKTWSEPKR
Protein: Nucleosome assembly protein (P25293)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acidic protein, which assembles histones into an octamer (in vitro). Involved in the regulation of the localization and the function of the septins during mitosis. Involved in the function of B-type cyclins.
Subcellular location: Cytoplasm. Nucleus. Bud neck. Note=Phosphorylation by CK2 promotes the import into the nucleus.
Interaction partners:
- Histone H2A.Z
- Probable serine/threonine-protein kinase KCC4
- Protein NIS1
- Histone H2A.1
- Histone H2A.2
- Lysophosphatidic acid:oleoyl-CoA acyltransferase 1
- Importin subunit beta-5
- Vacuolar protein sorting-associated protein 75
- Protein NBA1
- Histone H2A.Z-specific chaperone CHZ1
Sequence:
MSDPIRTKPKSSMQIDNAPTPHNTPASVLNPSYLKNGNPVRAQAQEQDDKIGTINEEDILANQPLLLQSIQDRLGSLVGQDSGYVGGLPKNVKEKLLSLKTLQSELFEVEKEFQVEMFELENKFLQKYKPIWEQRSRIISGQEQPKPEQIAKGQEIVESLNETELLVDEEEKAQNDSEEEQVKGIPSFWLTALENLPIVCDTITDRDAEVLEYLQDIGLEYLTDGRPGFKLLFRFDSSANPFFTNDILCKTYFYQKELGYSGDFIYDHAEGCEISWKDNAHNVTVDLEMRKQRNKTTKQVRTIEKITPIESFFNFFDPPKIQNEDQDEELEEDLEERLALDYSIGEQLKDKLIPRAVDWFTGAALEFEFEEDEEEADEDEDEEEDDDHGLEDDDGESAEEQDDFAGRPEQAPECKQS
Protein: Aliphatic amidase (EC 3.5.1.4) (Acylamide amidohydrolase) (P11436)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia. Enables the organism to use acetamide as both carbon and nitrogen source.
Interaction partners:
- Aliphatic amidase regulator
- Aliphatic amidase expression-regulating protein
- ATP-dependent protease ATP-binding subunit-like protein AmiB
- Putative transporter protein AmiS
- Guanidinobutyrase
- Probable aldehyde dehydrogenase
- Probable aldehyde dehydrogenase
- Probable aldehyde dehydrogenase
- aldehyde dehydrogenase
- Acylphosphatase
Sequence:
MRHGDISSSNDTVGVAVVNYKMPRLHTAAEVLDNARKIAEMIVGMKQGLPGMDLVVFPEYSLQGIMYDPAEMMETAVAIPGEETEIFSRACRKANVWGVFSLTGERHEEHPRKAPYNTLVLIDNNGEIVQKYRKIIPWCPIEGWYPGGQTYVSEGPKGMKISLIICDDGNYPEIWRDCAMKGAELIVRCQGYMYPAKDQQVMMAKAMAWANNCYVAVANAAGFDGVYSYFGHSAIIGFDGRTLGECGEEEMGIQYAQLSLSQIRDARANDQSQNHLFKILHRGYSGLQASGDGDRGLAECPFEFYRTWVTDAEKARENVERLTRSTTGVAQCPVGRLPYEGLEKEA
Protein: ATP-sensitive inward rectifier potassium channel 14 (Inward rectifier K(+) channel Kir2.4) (IRK-4) (Potassium channel, inwardly rectifying subfamily J member 14) (O70596)
Organism: Rattus norvegicus (Rat)
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Potassium voltage-gated channel subfamily Q member 5
- Potassium voltage-gated channel subfamily KQT member 2
- Guanine nucleotide-binding protein G
- Potassium voltage-gated channel subfamily KQT member 3
- Potassium voltage-gated channel subfamily KQT member 1
- Potassium voltage-gated channel subfamily KQT member 4
- ATP-sensitive inward rectifier potassium channel 12
- Inward rectifier potassium channel 2
- Inward rectifier potassium channel 4
Sequence:
MGLARALRRLSGALEPGNSRAGDEEEAGAGLCRNGWAPGPVAGNRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLTFWLIASLHGDLAAPPPPAPCFSQVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDRRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQYEVDYRHFHRTYEVPGTPVCSAKELDERAEQASHSPKSSFPGSLAAFCYENELALSCCQEEDEEEDTKEGTSAETPDRAASPQALTPTLALTLPP
Protein: Allene oxide cyclase 1, chloroplastic (EC 5.3.99.6) (Early-responsive to dehydration 12 protein) (Q9LS03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the production of 12-oxo-phytodienoic acid (OPDA), a precursor of jasmonic acid.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:12777050}.
Interaction partners:
- Allene oxide synthase, chloroplastic
- 12-oxophytodienoate reductase 3
- 12-oxophytodienoate reductase 2
- 12-oxophytodienoate reductase 1
- Putative 12-oxophytodienoate reductase-like protein 1
- Lipoxygenase 3, chloroplastic
- Lipoxygenase 2, chloroplastic
- Lipoxygenase 4, chloroplastic
- Lipoxygenase 6, chloroplastic
- Transcription factor MYC2
Sequence:
MASSTISLQSISMTTLNNLSYSKQFHRSSLLGFSKSFQNFGISSNGPGSSSPTSFTPKKKLTPTRALSQNLGNTENPRPSKVQELSVYEINDLDRHSPKILKNAFSFRFGLGDLVPFTNKLYTGDLKKRVGITAGLCVVIEHVPEKNGDRFEATYSFYFGDYGHLSVQGPYLTYEDSFLAITGGAGIFEGAYGQVKLQQLVYPTKLFYTFYLKGLANDLPLELIGTPVPPSKDVEPAPEAKALKPSGVVSNFTN
Protein: Thermostable carboxypeptidase 1 (EC 3.4.17.19) (Carboxypeptidase Taq) (P42663)
Organism: Thermus aquaticus
Function: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues, but not Pro.
Interaction partners:
Sequence:
MTPEAAYQNLLEFQRETAYLGSLGALAAWDQRTMIPRKGHGHRARQMAALARLLHERATDPRIGEWLEKVEGSSLVEDPLSDAAVNVRAWRRAYERARAIPERLAVELAQARSEGETAWEALRPRDDWQGFLPYLKRLFALAKEEAEILMAVGPDPLDPPYGELYDALLDGYEPGARARDLEPLFRELSSGLKGLLDRILGSGRRPDVGVLHRHYPKEAQRAFALELLQACGYDLEAGRLDPTAHPFEIAIGPGDVRITTRYYEDFFNAGIFGTLHEMGHALYEQGLPEAHWGTPRGEAASLGVHESQSRTWENLVGRSLGFWERFFPRAKEVFSSLADVRLEDFHFAVNAVEPSLIRVEADEVTYNLHILVRLELELALFRGELFLEDLPEAWREKYRAYLGVAPRDYKDGVMQDVHWSGGMFGYFPTYTLGNLYAAQFFAKAQEELGPLEPLFARGEFTPFLDWTRRKIHAEGSRFRPRALVERVTGSPPGAQAFLRYLEAKYGALYGF
Protein: TSC complex subunit 2 (Tuberous sclerosis 2 isoform C) (X5D2U8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
Protein: BBSome complex member bbs-2 (Bardet-Biedl syndrome 2 protein homolog) (Q19640)
Organism: Caenorhabditis elegans
Function: Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:15231740}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:15231740}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:15231740}.
Interaction partners:
- BBSome complex member bbs-4
- Protein pthb1 homolog
- BBSome complex member bbs-5
- BBSome complex member BBS1
- BBSome complex member bbs-7
- Tetratricopeptide repeat protein 8
- BBSome-interacting protein 1
- ADP-ribosylation factor-like protein 6
- Intraflagellar transport associated protein 2
- C2 domain-containing protein
Sequence:
MDGDRTPEEQIEIAESDQGPQLDDNVELANVFSYSLDQRIMEGCVISAILEPRGLETIVAVSVTNKIIIKDKETSLNITETIRCIAAAPFGDGYDCIIIGTDSSVICYDVHNNLTVFRNDVPDGVSCFVYGKLGELDEAIYCGGNCCIWGFDKTGANTYWTVTGDQVTTMCLSDYDNDGETELVIGSPDFEIRVFKNDLMRTELMETDEITCLAHVANGCFAYSLNNGTIGTYVLKERQWRIKSKSNVSKIFNFEEEGLMVVVWKQGKVDLRFAHNGEVLSRDSVSSHVASASVSKKGDESFITVVCLDGKVKGFKIQRAQNGSIDKTQQLIREFGQKKHNLMMELSNYEQEEQLADVEKDRDFRIPVDTEVAVVFVVNTELQLLSLRVEASHNIPIRGVLIFAEGLFEGESYIWIPPNEYQSRSVIDIPLVIDKDSTNDLHTKVFLGQVDSNKLMVMENTRILPKFCRFTLLREEYSKFFYMPTAYIQFDINSRAAKLSEWVQESFTIDASLVEMFDEPEGEFKFMGLRPKHEKSLMFKISHSEKTCKIYHDKIETMGAIVQSYASFYQIQNMESVAHFPDVFKEADEILEEIDPMTEVRDRLTAELQERQAAVKEIIIRAEDSIAIDNIPDARKFYIRLKANDAAARQAAQLRWNNQERCVKSLRRLNKIIENCSRLRVGEPGRQIVVSCRSAIADDNKQIITKILQYGASV
Protein: Brahma associated protein 170kD (FI23954p1) (A1Z6M0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH08712p
- Supporter of activation of yellow protein
- Polybromo
- Brahma associated protein 155 kDa
- Bromodomain containing 7/9
- Brahma-associated protein of 60 kDa
- ATP-dependent helicase brm
- Brahma associated protein 111kD
- Brahma associated protein 55kD
- Trithorax group protein osa
Sequence:
MSATTIDNVRVLLQSLPAAAVNSATQPGDLQTPGKIAAPATPLRAKNPAQLQIMPEKVEEMPPSPPEEFWRDLQQFHERRGTPLTQPARISGKHVDLYKLYNEVTERGGFNKVTMRDEWDEVYSAMETLRERCVNGTASIKHIYRRYLDKYERLNFFGEDPDKMEALEAAIEIVEMGGGRSRSRFLAGAGGGLGSIFGSAHSTLPAVPMAYNQRQHSVNVERRRQYKMSTQLHRHSSYEKLLLSLLSPLPNEQDFAINVCTLMANEARHTLQLSECPKLLDVLLAHLGVYADFTMRQLFQHSYTEVRHHSQLSFWRDLLHDKPQVLELYTDEQAWLDNGLISKEDGENSAARSELLAACDELHFLNLRRSNGTDERMGQRVLQIVQLVRTLSFHQENHALLASNRTLWRYLVMGANVRWSNIHIQALETAGNLAQQFELLDPTTDELSRNLLATLCEGIDSNDRAVIMSCLEILYKLCGREGNSQHINRCLGLDFYQRAMLLLSLTDVMMIIFTLEAVYALSALGARPCSMLMQVRGLIDQLVTLITVEAQSYGTGGCILMRVVEVFPGNMAASLAQNMPAILAPGPTSLTTLPTSLQVAVKPPAVLPTPTPAQTQVLPHGEQTPLVTALPGLPMPSLPQVQLPVPSLPQVQLPPIAATVTLPSLPSASQSFTHEDEQYALAWLGATYERAGNGNDLRVEQAELYRIYLSHCQKAGKLSVVNHMQFPRLVRLIFNQSVGPVIVRHLDGIELPGTYYVGIRMRAQPLAMQQRPTPSIVPVKKDTPILPKQPFSDPVQTEVASEESVSSAVTPPPSSSLIKSLLANKVTERQQKQKAQAQTPQPPALVATTASGTNATQPIKVTSTAISAFVNNPLMQHTPVKVGQTTIKPLHPQMAIEKKPITDSAPPPLAPLSGANVVTKDASGRTLIIASAAAKRKLTIDEEQNKRLALDAAASSSSSSSSGGKEEAQVTPSKNAANLYADLAASILEDEDMDDVPPLAKPSQEQSQQHPQQAQQLQLIPAKVQPTQRQLVFPGSNVVSPAPHSQLKLATTATIKTDQGLQTVPVILQPKTAMDSTPAPQTQYVLATNQQGQTYLVAQQPTIPTSTQSAPPTLLVTQTPQQQTKTIIILQQPGGVSAANVAGTQKMIMTTAQGQQVLVTTTTAPQLAQPRTSTPQQQIFIAPQRPVPALGAGQMSPSLLSQLNQIPATIKLHQPQPQPQLVSPQLAPQQRLVAAKPGASLPIPQLQQHQSIIQQHIISGPSTPTSTVGGTVGGEKRQVILGGIKETTLITQTSATPAPLQQSQLNSQTIITQSPTSTAIVGGVALQQQHHIRSVLDQQQQHHPSIIQQKITMPAISEATKPKIAPVPVSPTVTLLAKKPAPPQPAQVSSPKPSVTQAVVVTTSGTSDSTEGGKTVVLATSEAKPAESEVVAQTVVPPAVVTTGPSSSSLVVSQSVYAASGPNANPTPSPMPVDANWLYICDWRNCPRKKFKSLNELQYHVCSVHCPDHLDSDADIYCQWGSGPNFCDNRARKRYSLMTHLIDRHLTTENLRASVQRRLATGIHNVAPTQAPVTIVRNEGHAQRLAGGATGSPSGPASAVPVVGSAAMQAMNRHTTDYTNAKELMDENEGPVTKSIRLTAALIIRNLVTYSATAKRSLKRYESRLANVAFSNVEASGVLSHIMYELSQ
Protein: Nuclear protein localization protein 4 homolog (Q9VBP9)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.
Interaction partners:
- Ubiquitin fusion degradation protein 1 homolog
- Transitional endoplasmic reticulum ATPase TER94
- Phospholipase A2 activator protein, isoform A
- UBX domain-containing protein 7
- Derlin
- Derlin-1
- Ubiquitin thioesterase Otu1
- Ubiquitin conjugation factor E4 B
- Caspar, isoform A
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MACAPLLLEQFIYKKRNFAYAFVRHRLFVLCKQSLIRVQSAEGIKRIEISPKSNLKHLYDSVQNALKVDGFGLFKERNFLTELQASGSQLVGTSLRHGDMVYLKQMAGTSSRRTSTTVLDSQAFKTSTISNPNSARPSFNVIEDDVDQALSKADGTIKRERDSKLCHHNANGRCVHCSALEPYDESYLKEHNIKHLSFHSYIRKQTSGMDQGKYFVFDDINCRIKPGCREHPPWPKGICSKCQPSAITLNRQTYRHVDNVMFENTKIVERFLNYWRTTGHQRMGYLYGTYEQHTDVPLGIRAKVAAIYEPPQESTRDSINIQPDEFADDVDAVASALGLKKIGWIFTDLITDDASIGTVKQIRGIESHFITAQECITAGELQNRHPNPCKYASNGVFGSKFVTICVTGDKTKQVHMEGYAVSAQCMALVRDNCLIPTKDAPELGYVRESTDKQYVPDVFYKEKDLYGNEVQRLARPLPVEYLLVDVPASTPLQPIYTFTEYDKRQPFPIENRYIDGHLQDFNALSCYLSAWGEEEFLEAISDFHLLVYLYKMDMLPLRQHMGPLLEAVRTKNPNQAAQFKVVDVWKLLESLIQASSGGSGGTTSYPSGGASASAGASGSEAMDLDANTWTCNHCTFINRGELTSCEICSLPR
Protein: Cullin-3 (Cul-3) (Q09760)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable core component of multiple cullin-RING-based BC3B (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the BC3B complex depends on the substrate recognition component (By similarity). Involved in ubiquitin-mediated degradation of btb3.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- RING-box protein pip1
- COP9 signalosome complex subunit 5
- Ubiquitin-like protein 1
- BTB/POZ domain-containing protein 3
- Cullin-associated NEDD8-dissociated protein 1
- BTB/POZ domain-containing protein 1
- COP9 signalosome complex subunit 4
- NEDD8-conjugating enzyme ubc12
- Defective in cullin neddylation protein 1
- Elongin-C
Sequence:
MQRSAKLKIRAPRKFSANQVDFATHWEVLQRAIGDIFQKSTSQLSFEELYRNAYILVLHKYGEKLYNHVQDVIRSRLKEETVPAIYKNYDASLLGNALLDIRKNDSYSTSWSRSLEAAHRFLSSLVNSWKDHIVSMQMISSVLKYLDKVYSKSADKVPVNENGIYIFREVVLLNSFEIGEKCVETILILVYLERKGNTINRPLINDCLDMLNSLPSENKKETLYDVLFAPKFLSYTRNFYEIESSTVIGVFGVVEYLKKAEKRFEEEKERSKNYLFTKIASPLLSVVEDELLSKHLDDLLENQSTGFFSMIDSSNFEGLQLVYESFSRVELGVKSLKKYLAKYVAHHGKLINETTSQALEGKMAVGRLSSNATMATLWVQKVLALWDRLNTIISTTMDADRSILNSLSDAFVTFVDGYTRAPEYISLFIDDNLKKDARKAIEGSIEATLQNSVTLFRFISEKDVFEKYYKTHLAKRLLNNRSISSDAELGMISRLKQEAGNVFTQKLEGMFNDMNLSQELLQEYKHNSALQSAKPALDLNVSILASTFWPIDLSPHKIKCNFPKVLLAQIDQFTDFYLSKHTGRKLLWYPSMGSADVRVNFKDRKYDLNVSTIASVILLLFQDLKENQCLIFEEILEKTNIEVGDLKRNLQSLACAKYKILLKDPKGREVNAGDKFYFNENFVSNLARIKISTVAQTRVEDDSERKRTLEKVDESRKHQADACIVRVMKDRKVCEHNQLMAEVTRQLNPRFHPSPMMIKRRIEALIEREYLQRQADNGRIYEYLA
Protein: Fife, isoform B (M9PDV6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MLPTNVMSFMKKMVATDEQTSERQQHAADSGGGASQTGALNKMKATISSSLLTVTDKVNKMSPRPSLVPTDADTSGSYGSPSYQSQQQQQQDYGSSLNNNNNNSSGGGTATTGGGGGGAAAKQEPGRRAGACRVCLKSFKPDDYHKTCFECQQRVCEDCASYSKLDEHEDATMWRCSVCRRKMASRVCIPQDSTDSMLDVPVLEALQRRHSDAKLGSSTQTLAPSNGAALAPPRSPELRRHSDVSPASLKELERQLKGGRSMAPSRSNSPPRGEGPDGQPPFGAPLSRMQSRRGSRVARQHSYDDDMKTGPVGGSMGGGGPALGLGADGAGLGIPTMPRRKSAYDVFAPGLTQGGATPATQLQRSPGEGGIMPPIQLPGSRRPSFRVPHPSEDIQNDDSPGSPDKGSPVLTVDDDRRMRRRGSQLPDIAMLQNRGALPAVPPSSIPPPMASFTGPNLEDLEAPRRQTSMDGEAIRIVIHDVDSGPICASKRRIILRRDPTDKAHRTRGFGMRVVGGKTGADGRLFAYIVWTVPGGAAEKNGLQQGDKILEWNGMSLIDRSFEEVCSIMDRTGDVVELLVEHATDFRMCDLFDENLPPGNAGGQSGPRRSGDGPVGLGLIAEPETTTDKSPASPTRRKLPKTPEQIAREKLVTGRVQIQVWYHAERSELVVSLMAGDDLAPRDEAYGHGNLPEAYAKVRILPKCGDGSVQQTEVSRPTQNPIWNATLTFGHVKADTLMVRYIDIQLWDLVPHTESIFLGECSIELQQAFLDDQAIWCRLEDTKGLRGISISKSPSVSPRGSIAAGAGAPSGDVTRLLRRDYNMQRSNSDDVDSIGDGTSLLHPDHAWIAGSRRGSSQSETMEVEVYQLGKDFSRSLPGSRRSSFQDAEKNRLEEDAMATPPTSYLVGRRRSSVARRDPDEILKSLKAVRGELGRTMSLGTEQHKRMGSRPTISVSHYQSFDTPYTNWTKH
Protein: Exported protein family 4 (C0H4I0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MNFFHVIILDVGIVICLYLIIYKNSDIKWKKHINCCKYHFYFFSSKRCLLQHMVEEPFEKKDKSGVLLKDKNTEEGRKKERQKPMSIKSINKKKKKNNNNNNNNNVLKNLNNEEINKQRNMTNERIRNKNKNDKGVENISSNTQMEEKNIICKDINSNVILNQNEINDDQMVQKIKENFVKDLMKNENKEIFKQIETINSVGTMAKIKNSLYSIIFKGSNFWKGLGIYLGTLSGAVLGQLILAGILQFGTFSVMNFSIYFSAVPSFIAFSSFVGIILLSIIIVICLLVWLWPSRGKLMGKDKTENKSDT
Protein: EG:132E8.1 protein (Sister-of-Sex-lethal, isoform D) (O76876)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD31543p
Sequence:
MSNADKMQDQEHDDEQSSDIEGSGDNVGRDDGTDDDDDSNGNMQQENGDGGNGGDGQEHSGDEEQHHSQDNEGNDNSAGQQQQMQQVDRTSATNLIINYLPQDMTDRELYNLFSGCGPINTCKIMRDFKTGYSFGYGFVDYKTESDSEDAIQKLNGFYVRNKRLKVSYARPGGQSIKDTNLYVINLSRNINDDMLDRIFSPYGLIVQRNILRDKLTGRPRGVAFVRYNKREEAQEAIKALNNTVPEGGSQPIWVRLAEEHGKAKAAQFMAQIGGGNGGGGGGPPHMGPGGPMHPPHHHNNHHHNNHHNPHMPPHHHQPQHPHQHPQHHPQLHHMQHHHPNNHNNNHPNNHHHNNNNNNHHNMGGPHPHHMQQMHPMGMNMGMGVNMGMGMGMGMPIHGGGGGGGGGGGGGGGGNFHHMAHRGEVFMLPLPICSRFPSQPHPVGNGICHSPNKNSRFRLSRRPQASRTTIRYIAHSVADPVPTPTT
Protein: Kallikrein-12 (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5) (Q9UKR0)
Organism: Homo sapiens (Human)
Subcellular location: Secreted.
Interaction partners:
- Serine protease inhibitor Kazal-type 6
Sequence:
MGLSIFLLLCVLGLSQAATPKIFNGTECGRNSQPWQVGLFEGTSLRCGGVLIDHRWVLTAAHCSGSRYWVRLGEHSLSQLDWTEQIRHSGFSVTHPGYLGASTSHEHDLRLLRLRLPVRVTSSVQPLPLPNDCATAGTECHVSGWGITNHPRNPFPDLLQCLNLSIVSHATCHGVYPGRITSNMVCAGGVPGQDACQGDSGGPLVCGGVLQGLVSWGSVGPCGQDGIPGVYTYICKYVDWIRMIMRNN