wanglab/gogpt-training-data huggingface dataset:
Protein: Cell division topological specificity factor homolog, chloroplastic (AtMinE1) (Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 12) (Q9C4Z7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a topological specificity factor during plastid division and specify plastid constriction sites (such as the Z-ring) in a MCD1-dependent manner. Especially involved in epidermal plastids division in a FTSZ1-dependent manner. Required for the proper formation of FtsZ rings at the division site in nongreen plastids (e.g. etioplasts). May contribute to gravitropism in stems and hypocotyls. Stimulates MIND1 ATPase activity. In cooperation with MIND1, prevents FtsZ ring formation anywhere outside of the mid-plastids.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:11743109, ECO:0000269|PubMed:12029464, ECO:0000269|PubMed:12164807, ECO:0000269|PubMed:16146521, ECO:0000269|PubMed:17855384, ECO:0000269|PubMed:26500667}. Note=Dynamic protein that is restricted to a single spot at one end of chloroplasts or as two spots in close proximity normally towards one end of the chloroplast. Seems attached to membranes.
Interaction partners:
- Septum site-determining protein minD homolog, chloroplastic
- Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6, chloroplastic
- Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 3
- Cell division protein FtsZ homolog 1, chloroplastic
- Protein MULTIPLE CHLOROPLAST DIVISION SITE 1
- Plastid division protein CDP1, chloroplastic
- Dynamin-like protein ARC5
- ACT domain-containing protein ACR6
- Chromophore lyase CRL, chloroplastic
- BEACH domain-containing protein B
Sequence:
MAMSSGTLRISATLVSPYHHHHRNRLSLPSSSSKVDFTGFISNGVNSLETQKCTPGLAISRENTRGQVKVLARNTGDYELSPSPAEQEIESFLYNAINMGFFDRLNLAWKIIFPSHASRRSSNARIAKQRLKMILFSDRCDVSDEAKRKIVNNIIHALSDFVEIESEEKVQLNVSTDGDLGTIYSVTVPVRRVKPEYQDVDEAGTITNVEYKDTRDGSVDVRFDFYVPE
Protein: E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) (Q6UWE0)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:27615052}. Note=Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501). Localizes to intracellular bacterial pathogens (PubMed:23245322). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322}.
Interaction partners:
- Tumor susceptibility gene 101 protein
- Calcium-binding and coiled-coil domain-containing protein 2
- Serine/threonine-protein kinase 25
- Serine/threonine-protein kinase 26
- Serine/threonine-protein kinase 24
- Vacuolar protein sorting-associated protein 28 homolog
- Centrosomal protein of 55 kDa
- E3 ubiquitin-protein ligase RNF166
Sequence:
MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLLSQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVRPSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIYHSS
Protein: Putative cation/proton antiporter YbaL (P39830)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}.
Interaction partners:
Sequence:
MHHATPLITTIVGGLVLAFILGMLANKLRISPLVGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGLHFSLKDLMAVKAIAIPGAIAQIAVATLLGMALSAVLGWSLMTGIVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWLIVEDLVMVLTLVLLPAVAGMMEQGDVGFATLAVDMGITIGKVIAFIAIMMLVGRRLVPWIMARSAATGSRELFTLSVLALALGVAFGAVELFDVSFALGAFFAGMVLNESELSHRAAHDTLPLRDAFAVLFFVSVGMLFDPLILIQQPLAVLATLAIILFGKSLAAFFLVRLFGHSQRTALTIAASLAQIGEFAFILAGLGMALNLLPQAGQNLVLAGAILSIMLNPVLFALLEKYLAKTETLEEQTLEEAIEEEKQIPVDICNHALLVGYGRVGSLLGEKLLASDIPLVVIETSRTRVDELRERGVRAVLGNAANEEIMQLAHLECAKWLILTIPNGYEAGEIVASARAKNPDIEIIARAHYDDEVAYITERGANQVVMGEREIARTMLELLETPPAGEVVTG
Protein: Adipocyte plasma membrane-associated protein Hemomucin (Protein Hemomucin) (Q9VB46)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transmembrane mucin that may be involved in cellular adhesion and the innate immune response. Membrane-tethered mucins are involved in many cell surface functions and form a physical barrier around cells to regulate cell-cell and/or cell-substrate interactions, and protect against pathogens or harmful extracellular conditions. This mucin likely acts in hemocyte adhesion as it is released from hemocytes during coagulation and is also able to bind lipophorin particles which form part of the hemocyte coagulogen. Able to induce expression of the antibacterial proteins in the presence of GalNAc-specific lectins and so probably also functions in the innate immune response.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8662683}; Single-pass membrane protein {ECO:0000255}. Note=Detected on membrane of hemocytes. {ECO:0000269|PubMed:8662683}.
Interaction partners:
- CTP synthase
- Elongation factor Ts, mitochondrial
- Eukaryotic translation initiation factor 5B
- FI21480p1
- Large ribosomal subunit protein bL20m
- rRNA biogenesis protein RRP5
- U3 small nucleolar ribonucleoprotein protein IMP3
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein uL3
- FI01658p
Sequence:
MGLLYALRVRIMNFMIFFLLIILMPGLPPRTTFPFKDYIVTPPKDLKGALESNFHLEGAERLLEGRVYGPECLIARNNEIYTGIHGGEVIKLTSNHVTHVTKIGQPCEDIYEESRCGRPLGLAFDTQGNNLIIADAYYGLWQVDLGTNKKTLLVSPAQELAGKSINRPAKIFNGVTVSKEGDVYWTDSSSDFTIEDLVFASFANPSGRLFKYNRSKNVSEVLLDELAFANGLALSPNEDFIVVAETGAMRLTKYHLKGAKAGQSEVFVDGLPGLPDNLTPDAEGIWVPLVQSADSEHPNGFTLFTRFPSVRLFLARMLALFELPFRYLNSVYPNKFSQRFVHFVGHMESITVLAPKRTTVVRVDWNGNIVGSLHGFDKSAATVSHVLEFQDFLFLGSPTNQYLARVKSPKAKQPTLKVRNVRVEGEGLEASIGVPPSKATPKPKAAPSTTTPKPTTTTTTTTPKPTTKTTTTTTTPKPTTTTTTKKPTTTTTTTTTTPKPTTTKPPTAKPSTTTTTTTTPKPTTTTTPTTPTPEPSKPKVKRTVPEKPAPVEEDIPSDTQPPKKEKLKVINKQGVNVEL
Protein: Carboxypeptidase Z (CPZ) (EC 3.4.17.-) (Q8R4V4)
Organism: Mus musculus (Mouse)
Function: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Peroxiredoxin-6
- Gamma-aminobutyric acid receptor subunit beta-3
- Alpha-globin transcription factor CP2
- AF4/FMR2 family member 1
Sequence:
MPTMPLLLAALAALAVLALAARPSPSCSPGPDPSGKCQRLVYTHSATCVDLHLRTCADAAYNHTSFPTPLEHRSWEAVESSPEYMLLGVIHFLLEGQCNPDLRLLGCSVLAPRCEGGHTQRPCRHVCEGLREACQPAFDAIDMAWPYFLDCAQYFAPEEEGCYDPLEELRGELDVEEALPSGLPPTFIRFAHHSYAQMVRVLKRTAARCSQVAKTYSIGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREVLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTRGVRTDHIPISQYYWWGKVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKNPHEKKMFSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYGLWQQNKEPLLNFLEMVHRGIKGMVTDKYGKPVKNARILVKGIRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYSKVMKRVTIPLRMKKAGRVDFILHPLATGPKNFLPGPSRALPRFQDPQREPTQMDFEPPRARRQPASGSKPWWWAYFTSLSPYKPRWLLKY
Protein: Leucine-rich repeat extensin-like protein 3 (AtLRX3) (LRR/EXTENSIN3) (Cell wall hydroxyproline-rich glycoprotein) (Q9T0K5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization.
Subcellular location: Secreted, cell wall {ECO:0000250|UniProtKB:O48809}.
Interaction partners:
- Rapid alkalinization factor 23
- Ferritin-4, chloroplastic
- GPI-anchored protein LLG1
- Protein RALF-like 1
- Extensin-3
Sequence:
MKKTIQILLFFFFLINLTNALSISSDGGVLSDNEVRHIQRRQLLEFAERSVKITVDPSLNFENPRLRNAYIALQAWKQAILSDPNNFTSNWIGSNVCNYTGVFCSPALDNRKIRTVAGIDLNHADIAGYLPEELGLLSDLALFHVNSNRFCGTVPHRFNRLKLLFELDLSNNRFAGKFPTVVLQLPSLKFLDLRFNEFEGTVPKELFSKDLDAIFINHNRFRFELPENFGDSPVSVIVLANNRFHGCVPSSLVEMKNLNEIIFMNNGLNSCLPSDIGRLKNVTVFDVSFNELVGPLPESVGEMVSVEQLNVAHNMLSGKIPASICQLPKLENFTYSYNFFTGEAPVCLRLPEFDDRRNCLPGRPAQRSPGQCKAFLSRPPVNCGSFSCGRSVSPRPPVVTPLPPPSLPSPPPPAPIFSTPPTLTSPPPPSPPPPVYSPPPPPPPPPPVYSPPPPPPPPPPPPVYSPPPPPPPPPPPPPVYSPPPPSPPPPPPPVYSPPPPPPPPPPPPVYSPPPPPVYSSPPPPPSPAPTPVYCTRPPPPPPHSPPPPQFSPPPPEPYYYSSPPPPHSSPPPHSPPPPHSPPPPIYPYLSPPPPPTPVSSPPPTPVYSPPPPPPCIEPPPPPPCIEYSPPPPPPVVHYSSPPPPPVYYSSPPPPPVYYSSPPPPPPVHYSSPPPPEVHYHSPPPSPVHYSSPPPPPSAPCEESPPPAPVVHHSPPPPMVHHSPPPPVIHQSPPPPSPEYEGPLPPVIGVSYASPPPPPFY
Protein: Histone H2A (C1BEH9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003767}.
Interaction partners:
- Myb-like, SWIRM and MPN domain-containing protein 1
- Myb-like, SWIRM and MPN domain-containing protein 1
- Histone H4
- Histone H2A/H2B/H3 domain-containing protein
- Histone H2B
- Histone H2A
- Histone H3
- Histone H3
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTEKPAKSK
Protein: Homeobox protein Dlx3b (DLX-3) (Distal-less homeobox protein 3b) (Q01702)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in the development of the inner ear.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Forkhead box I1.
- Paired box protein Pax-2a
- Forkhead box protein D3
- Eyes absent homolog
- Cathepsin Lb
- Transcription factor AP-2-alpha
- Fibroblast growth factor 8
- Paired box protein Pax-8
- Transcription factor SOX-10
- Homeobox protein six1b
Sequence:
MSGPTYDRKIPGISTDLSGSMSCHPTSKDSPTLPESSATDMGYYSSHHEYYQSPPYPQQMNSYHQFNLSGMGATPGAYPTKTEYPYNTYRQYGHFNRDLQTPPQSAVKEEPETEVRMVNGKPKKIRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNASDSMACNSPPSPAVWDNNAHSSQVNRGQIPQPPLSSTPPYMEDYSNHWYQQGSHLQHPVHHPGPPQSVGAVY
Protein: Uncharacterized protein YCR043C (P25361)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Putative uncharacterized protein YCR047W-A
- Mannan polymerase II complex ANP1 subunit
- Protein SNA3
Sequence:
MIPAPLDASLLREHAFQGTNDLSTVLSPSTFTDEGGYKPVLKYGLGYFNYGLVIDDEVYDYSVCDIIRGHVYDHFWCYFCCFMILFTIWLISLNWCPSSKKSKFDWSKKKDDFKMEGGDLEYQHVKI
Protein: Large neutral amino acids transporter small subunit 1 (O17395)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGKQEQSEPLNQEPSNEHHDEEVGDKGLEKTMTLFNGVSIIVGCIIGSGIFISPTGIQAQAGSVGLSLIVWVLSGLFAGIGAFCYAELGTLIRKSGGDYAYIMEAFGPFLAFLRLWIESIVVRPCTATIVALTFAIYMLKPFYPDCDSPPLSTELIAALLLVLLTAVNCISVKWASKVQDFFFVTKTAALVLIIFTGLWNMVSGKPEAFDSFENIFENTAKDLETASLAFYSGLFAYQGWNYLNFIVEELQNPKRNLPLSIAISCSLCTIIYTLTNVALYTSITPDEMLASPAVAVLFAEKNYGWFAFCMPIFVACSTIGSANGVILTSSRLFYCGAREGQMPNVLTMVNKTTKTPIPAVILTGLLSLLYLLLSNNIYSLINYIQVSYWIAIGGAILALFYFRKTMPDAPRAVKAPIVFPIIFFIGCVLLVLVPVLGNPKDTAIGILIMLSGVPVYLIFIAWKGKPKCIDSLTDSVTIFTQKLFMVVDANKEE
Protein: Stabilin 2 (Stabilin-2 isoform X1) (F6P8Y7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Protein SLX4IP
- Adhesion G protein-coupled receptor B3
- Apolipoprotein Ba.
- Hepatitis A virus cellular receptor 1.
- Scavenger receptor class F member 1
Sequence:
MPFLLDVVCGGLILLLGTEILWVAGAQKRCDKDITMVTKSKCHSCSLSHLAKCPNGYAKMPPGTSDRDCRYYVTPVFSISGCSFNCFKEVVEPQCCRGYWGNDCMECPGSASTPCSNNGVCSDGIAGNGTCTCASGFTGAACEECKTDLYGPTCSNVCRCKNGLCSSGLKGTGECTCFSGYTGLDCAQELPACAALQCGPDSRCIEEMLTGQLVCKCKPGYQGDGVQCTSINPCLRSVCHANAVCAHTGPNKHVCTCTEGYSGDGRVCMPIDPCQTNLGNCTSGSTRCVYDGPGKAHCECLEGFEKFVEGQGCSIIDLCKPDSCHKYATCATAEPGTVECNCREGFIGNGKICFGDIIQQLNEMNSKPGGKWTGQLSSAITLFNQVTGWFLTARGPFTVFVPVNKAFKGTSVKSLLADEMKARYLAKLHVVAGEVNSESLKKGILFHTLTGMGAESMIDAEQVKIRLHGSRKKGALVESDIFASNGMIHLIDKLMDAVPSTVISEKEESLLEILSKNGKFSQFKSLLEKTNLATVLEEDGPYTLFAPTNVAFALMKPDYLAYLKSEEGKTKLLELMRNHIVSTTPLSAYVIVSNPRAVTMAEQILTFNVTTAGQILVNGESVIELDVEAKNGRLHSLEGLLIPPSIEPILPHRCDIIKPIKYMAPCVSCTLISKSTCPTGESLKAYRRGCVFNKKQLGLSLPSIGCSHICNDTKTTPQCCKGFFGPDCSPCPGGFTTPCSSHGTCSEGIDGNGTCQCEPKFKGSRCQYCADSNKYGPNCDKTCWCIHGTCDNHPEASGKCKQGSCKDGYTGEYCELQTQPCGPNQPCHAHANCVSNKGAFTCVCKPGFQGDGYMCMESDPCALPHRGGCSKNAICIKTGPGTHKCKCLSGWREDGDECQAINNCLDPSRGGCHPNATCIYVGPGQIDCACKSGYHGNGRECEPVNQCVEQKGGCHFLATCQFLNPDGWHCVCEDGYAGDGKICYGTLLQEVSTNPDLLGFNQWISKAELSQLLSERENLTLFVPSAQAIEKMSKEDKDIWMTPSNLPSLVKNHILSGSFTLSDLNTSPSPPPRLVSLLKRTLPVYSTNDTTIVAGGKITFGDMAAKNGVIHLIDTVLIPEQQMSEGLLQVLKKRSDLSLFYGSLLNHNLTNEMEESLGFTVFAPTDNAIQDYLKRTGKESLDLNVTMYHIILTEILKDVDLVDGLYKDTMLGFQYQLGFFRQDKRLLVNEAEVNVTDLETSKGVIHIISAVLNIPSNRCDKATSILFSGRCMDCFQTIINPCPSGTKKVMSRKRRCMYSRVLHGDTLLTIGCKFSCEKMTIERICCSGHYGINCEKCPGSEDQSCFGNGICKDGINGTGVCLCNQGFNGTACESCQPGKYGIHCDQECKCVHGRCKDGIDGDGSCACDLGWRGVNCDIAIKSDMCGGKCHSSANCLVNVVDSSYYCSCAAGFQGNGTYCEAIDACAERNGGCSAHAVCKRTLPGRRICMCHPGYAGDGNVCTSINPCLDGVNGGCHADSNCIHTGPNKTACHCKEGFYKDGKNCELINLCKEKNGGCHRAAICTMTGPLQRNCTCHAGYVGDGEICKYTLQRELSIETARTAFVKAMFKNRIYELDTRGPFTVFAFRSENYKNQSIDLVKRTPENTRIMRYHIVCCRTLLPQDLMQPRNLTTLSGDILSITYSENTIYINNKAKVLFSDIESSNGILHEIDSVLVPPGLEIREDKKQDIIPRNFSEVASANGFKTFFKLLEDTDTLKLVMDPIHQPVTLFMPTDDAMSALSQEQKDFLYAMHNRDKLSEYLRYHILRDTKLMASELIYASSLKTQQGSDLSVACMGEEQIGELYVNHKGCRIVKRYLDFNGGMIYGIECLLNPPSLGGRCDHRQTIDFTLACRSCGSSIMDCPLGSKPVGEQECVLPDSVISRGSKCQSTCKVVVWKPKCCSGYYGRDCLACPGGPQSPCSNHGKCDEDHLGNGTCTCDTGFTGVACESCLDGHFGPDCNACNCTEHGSCDEGLQGTGSCFCEEGWTGPQCENKLADGPVCNPACHEKGVCMENNTCVCKPFYEGDGITCTVANMCKYWNGGCSKDAKCSQKGEKVSCACLQGFSGDGFVCTPIDPCVDGENGGCHEHATCTMTGPGKRKCECKDSYVGDGIDCEAKVLPVNRCLVDNGQCHSDAQCTDLHHEDKTLGVFHYRSTNGTYKLNYTMAQEACKEAGSTIATYMQLSYAQQAGYSLCTAGWLDKARVAYPMSFSSPRCGSGHVGIVDYGVRNNLSETWDTFCYRVKDVQCKCKTGYIGDGFSCTGNLMQVLSATPTLSNFLSQILNFSTSASGKAFVNRLRNITIQSTLFVPDNDGLYSNQTLSGRDIEHHLLDGRALILQALINVTHVRTRLGSSLTITGVPDLQNPQKMTSSGYINDRYVIDSNIFASNGVIHVLQGPLKAPPPPTPSFHPAHQAGLGIGVLGLIILIVVAGFVGYNFYTHKTKPFQFHYFKEDEGEDVTPTESSPNISNPVYDAAPATKEQPPTEEDKHQVISSGVFDLLQDS
Protein: Serine/threonine-protein kinase-like protein ACR4 (EC 2.7.11.1) (Protein CRINKLY 4) (AtCR4) (Q9LX29)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Controls formative cell division in meristems, including root tips and lateral root initiation zones of the pericycle, in response to CLE40 signal. Acts with CLE40p peptide as a ligand-receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem. Required during embryogenesis and development, probably for the differentiation of protoderm and epidermal cells. Involved in the regulation of cellular organization during the development of sepal margins and ovule integument outgrowth and promotes giant cell formation. Can phosphorylate ALE2.
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein. Note=Also localized into protein export bodies. Internalization may be involved in degradation of ACR4 for its rapid turn-over. In the epidermis, mostly expressed in the lateral and basal planes of cells.
Interaction partners:
- CLAVATA3/ESR
- Protein CLAVATA 3
- Receptor protein kinase CLAVATA1
- WUSCHEL-related homeobox 5
- Calpain-type cysteine protease DEK1
- Receptor-like protein CLAVATA2
- Subtilisin-like protease SBT2.4
- Protein WUSCHEL
- Homeobox-leucine zipper protein MERISTEM L1
- S-locus glycoprotein family protein
Sequence:
MRMFETRAREWILLVKLVLFTSIWQLASALGSMSSIAISYGEGGSVFCGLKSDGSHLVVCYGSNSAILYGTPGHLQFIGLTGGDGFMCGLLMLSHQPYCWGNSAFIQMGVPQPMTKGAEYLEVSAGDYHLCGLRKPIVGRRKNSNIISSSLVDCWGYNMTRNFVFDKQLHSLSAGSEFNCALSSKDKSVFCWGDENSSQVISLIPKEKKFQKIAAGGYHVCGILDGLESRVLCWGKSLEFEEEVTGTSTEEKILDLPPKEPLLAVVGGKFYACGIKRYDHSAVCWGFFVNRSTPAPTGIGFYDLAAGNYFTCGVLTGTSMSPVCWGLGFPASIPLAVSPGLCIDTPCPPGTHELSNQENSPCKFTGSHICLPCSTSCPPGMYQKSVCTERSDQVCVYNCSSCSSHDCSSNCSSSATSGGKEKGKFWSLQLPIATAEIGFALFLVAVVSITAALYIRYRLRNCRCSENDTRSSKDSAFTKDNGKIRPDLDELQKRRRARVFTYEELEKAADGFKEESIVGKGSFSCVYKGVLRDGTTVAVKRAIMSSDKQKNSNEFRTELDLLSRLNHAHLLSLLGYCEECGERLLVYEFMAHGSLHNHLHGKNKALKEQLDWVKRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEEHNARVADFGLSLLGPVDSGSPLAELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVLLLEILSGRKAIDMHYEEGNIVEWAVPLIKAGDINALLDPVLKHPSEIEALKRIVSVACKCVRMRGKDRPSMDKVTTALERALAQLMGNPSSEQPILPTEVVLGSSRMHKKSWRIGSKRSGSENTEFRGGSWITFPSVTSSQRRKSSASEGDVAEEEDEGRKQQEALRSLEEEIGPASPGQSLFLHHNF
Protein: Filamentous growth regulator 27 (Q59NX5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor involved in yeast cell adherence to silicone substrate, filamentous growth, and biofilm formation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
Interaction partners:
- S-formylglutathione hydrolase
Sequence:
MSAPIVETKKASKRRIRRIPDDQRQKVSSACDNCKKRKFKCSGEKPCFECSKKGHDCTYTIIDKRSLRGERMAKLKQKKDNNEKQRELVNEQIAQSSIIHPQITPVLPVPEYANVTYQDSSHSTVSGNDSYHLSSSSSIPQNLPAIVLPDTLRDPNNRGILTPGSTPNSVSSESSVSNVCVPKSLQPLLSFPLENKNNLRHKSEEPDMDNNTNNVPKKGGISNQEGKSAILLVDKSGAFRYMGETSPLSVLYEARGIFYEYVGSTKLTEDLRGCPVTDKPLKITMKEAAPLPHPSERDVYIERFKVNINGAYFVFDMDKFYEEIVDKVYENPNSDLVQENRVLLYFVLAIGSTYKDFSERNPQAEKGAHYFESGRLILRDLVEDSAMWCVLCHYLQFHYYESILKKSTALVHLTAAINYAQSLGLHRNFVNEQFSKLTAEYEYRRKLFRSLYISDRISSVFIGRPLIINDYDWDDPARFKNTNASVLPLDFNSKCHIELTRICTLVGRIVANFYQDKMIDVKKTKNLAIQLRLWSKGLDPELAFGNVLNPSQISNNEDNGNTVILLGIHILHLWAVMLLSRPFFMFEAISKINPEMRKSFEEEEELSKQLCQAATKASILAIKLMNHYINTTFHEIKRMECYVIITCCFYASIILGITILNGTFEEAGYTENDLMNSLKDAQYILSQFSVCNKGAERYSEINLDLISALVNRHKGKEVKPVVDNWSCNLFNDFNFGDTSGQNDVQTMMDFQQFFVSSDLIQFEEITDGTSSLPFDYNNYNLFFGDKL
Protein: Vimentin (P31000)
Organism: Rattus norvegicus (Rat)
Function: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P08670}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P08670}. Nucleus matrix {ECO:0000269|PubMed:16128803}. Cell membrane {ECO:0000250|UniProtKB:P20152}.
Interaction partners:
- Desmin
- Caspase 7, isoform CRA_c
- Caspase-3
- Uncharacterized protein.
- Caspase-8
- Snail homolog 1
- Caspase-6
- Histocompatibility 2, class II antigen E alpha
- CD44 antigen
- Zinc finger E-box-binding homeobox 1
Sequence:
MSTRSVSSSSYRRMFGGSGTSSRPSSNRSYVTTSTRTYSLGSALRPSTSRSLYSSSPGGAYVTRSSAVRLRSSMPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAESTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHDEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESNEYRRQVQSLTCEVDALKGTNESLERQMREMEENFALEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLESLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE
Protein: adenine phosphoribosyltransferase (EC 2.4.2.7) (F4HSX1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MQTIIISPLVSHRLCLARAVPCNRLLNNHHRAPPSIRLSNHRSTTSLRLFSSAGSLCVCKSDAEYFAKAAASRDSEMATEDVQDPRIAKIASSIRVIPDFPKPGIMFQDITTLLLDTEAFKDTIALFVDRYKDKGISVVAGVEARGFIFGPPIALAIGAKFVPMRKPKKLPGTFLFLPLVACDFDIKLHERSQLGSWKVISEEYSLEYGTDTIEMHVGAVEPGERAIIIDDLIATGGTLAAAIRLLERVGVKIVECACVIELPELKGKEKLGETSLFVLVKSAA
Protein: 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10) (Type II DHQase) (P9WPX7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes a trans-dehydration via an enolate intermediate.
Interaction partners:
- 3-dehydroquinate synthase
- Probable shikimate 5-dehydrogenase AroE
- Shikimate kinase
- Chorismate synthase
- Small ribosomal subunit protein uS15
- Secreted chorismate mutase
- Putative isochorismate synthase MenF
- Salicylate synthase
- Urease subunit gamma
Sequence:
MSELIVNVINGPNLGRLGRREPAVYGGTTHDELVALIEREAAELGLKAVVRQSDSEAQLLDWIHQAADAAEPVILNAGGLTHTSVALRDACAELSAPLIEVHISNVHAREEFRRHSYLSPIATGVIVGLGIQGYLLALRYLAEHVGT
Protein: Decreased expression in renal and prostate cancer protein (P0CG12)
Organism: Homo sapiens (Human)
Function: Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.
Subcellular location: Nucleus {ECO:0000269|PubMed:12477976}.
Interaction partners:
Sequence:
MKEPRIFPRERPTPWTRAPLPPRGRLDGSLGPQGGPVLNTGHPLGVNSDPFLMAAGSLGGNLTPFPRNPSPFPASSGSLASNPAPFPAGARDPSMASFPRGMNPTGTGAVSFPRPGGLLGPGPGPGPTLNPRTGALPGPGPLSNPRLGGLPGPGPMSNPRAGGLLGAGPDPRGGGPMGPGSGPNLRAGVLLTSGNGPPNPRPVGLGPGPNPNLRSGFLGTNPAPRSGVFPGPGLGPNPRPSGLGPGPNLDARAGGLLGTGSGLNLRMAGPQGLDLAPILRAAGLLGANSASFSQASGNMGTSPSSMARVPGPMGPNSGPSSRGIGLPGPNPSPMSRAPGPIGPNSAHFSRPVGPMGVNANPFPRGAGSSAFSQSSGTLASNPATFQRSAGLQGSNPTIFPRASGPLGPNPANFPRATGLQGPSPTTFPRSTGPLGPGQVTFPRPAAGHLGPSPAGPVGINPAPFTRPTGTLGLNPASFPRMNGPAGKSFVPFPRVGSLPGTNPAAFPRPGGPMAAMYPNGMLPP
Protein: T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d) (P04234)
Organism: Homo sapiens (Human)
Function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- T-cell surface glycoprotein CD3 gamma chain
- T-cell surface glycoprotein CD3 zeta chain
- T-cell surface glycoprotein CD3 epsilon chain
- Tyrosine-protein kinase ZAP-70
- T-cell surface glycoprotein CD8 alpha chain
- CD8 subunit beta
- T-cell surface glycoprotein CD4
- T-cell receptor-associated transmembrane adapter 1
- Tyrosine-protein kinase Lck
- T-cell surface antigen CD2
Sequence:
MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK