wanglab/gogpt-training-data huggingface dataset:
Protein: Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18) (P15328)
Organism: Homo sapiens (Human)
Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Basolateral cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Secreted {ECO:0000305|PubMed:3476960}. Cytoplasmic vesicle {ECO:0000269|PubMed:8567728}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:8567728}. Endosome {ECO:0000269|PubMed:8567728}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. {ECO:0000269|PubMed:8567728}.
Interaction partners:
- Glutamate carboxypeptidase 2
- Proton-coupled folate transporter
- Poly
- Thymidylate synthase
- Epidermal growth factor receptor
- Mesothelin
Sequence:
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS
Protein: Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (Q7ZSX3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Recombination signal-binding protein for immunoglobulin kappa J region-like.
- NK6 homeobox 1.
- Insulin
- Recombination signal-binding protein for immunoglobulin kappa J region a.
- Pancreatic and duodenal homeobox 1.
- Forkhead box protein N4
- Insulin
- BarH-class homeodomain transcription factor
- Carboxypeptidase A1
- Glucagon b
Sequence:
MDTVLDPFTGLDSFSSSYFDDDDFFTDHSSRDHLDTDDFLDEDVDFLTNQIQEYYKDSRISQDGDYCDVGNFSFSSSSSTFSYGCADSTSELSPHRDGGLLKRRRRMRSEVEMQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLAELVQSDMPIRNPHSDALNQPKKVIICHRGTRSPSPNDPDYGLPPLAGHSLSWTDEKQLKDQNIIRTAKVWTPEDPRKLHLKSSINNIENEPPFNFIS
Protein: Tyrosine recombinase XerC (P9WF35)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Phosphoribosyltransferase
- Adenine phosphoribosyltransferase
- Probable integrase
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- Uncharacterized protein Rv2895c
- Probable conserved proline, glycine, valine-rich secreted protein
- Abasic site processing protein
- Prephenate dehydrogenase
- Probable cell division protein WhiA
- DNA translocase FtsK
Sequence:
MQAILDEFDEYLALQCGRSVHTRRAYLGDLRSLFAFLADRGSSLDALTLSVLRSWLAATAGAGAARTTLARRTSAVKAFTAWAVRRGLLAGDPAARLQVPKARRTLPAVLRQDQALRAMAAAESGAEQGDPLALRDRLIVELLYATGIRVSELCGLDVDDIDTGHRLVRVLGKGNKQRTVPFGQPAADALHAWLVDGRRALVTAESGHALLLGARGRRLDVRQARTAVHQTVAAVDGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVARLRAVHERAHPRA
Protein: F-box only protein 42 (Just one F-box and Kelch domain-containing protein) (Q6P3S6)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.
Interaction partners:
- Cullin-1
- S-phase kinase-associated protein 1
- E3 ubiquitin-protein ligase RBX1
- Cellular tumor antigen p53
Sequence:
MASSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR
Protein: Uncharacterized protein YGR017W (P53210)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Putative pyridoxal kinase BUD16
- Putative pyridoxal kinase BUD17
- Pyridoxamine 5'-phosphate oxidase
- Probable pyridoxal 5'-phosphate synthase subunit SNO2
- Probable pyridoxal 5'-phosphate synthase subunit SNO3
- Pyridoxal 5'-phosphate synthase subunit SNO1
- Putative pyridoxal reductase
- Pyridoxal 5'-phosphate synthase subunit SNZ1
- Probable pyridoxal 5'-phosphate synthase subunit SNZ2
- Probable pyridoxal 5'-phosphate synthase subunit SNZ3
Sequence:
MSHQMAPWIPMFIQSCKNNTEPFVSFQFATVDELTNKPRCRTVVFRDFLFHDKRTNVLTFNTDMRSSKITESFITPNSNNSSDSKRCETPFFEACFYFPETWEQYRFSGQCFTISKQFKKIPAEIVTKYDIFSPRFSETNDDSTDEEIDTPINDDDDDDKNNDADNNDINEDNKLIESIENDEHHEDEDDYYPQPQEWEAELLRQWSSLSRHTKSLYRKPAPGQKLTSETSKQLDKLHRGVDGAKEDAGLENFGIVCLCVDSVDFLNLKEGRGGERWIFQKTDGKDEDLWEEQEVCP
Protein: T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (Spleen, mucin-containing, knockout of lymphotoxin protein) (SMUCKLER) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4) (Q6U7R4)
Organism: Mus musculus (Mouse)
Function: Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells. Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity). Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Adhesion G protein-coupled receptor B1
- Stabilin-2
- Growth arrest-specific protein 6
- Galectin-9
- Tyrosine-protein kinase Mer
- Tyrosine-protein kinase receptor TYRO3
- C-type lectin domain family 4 member F
Sequence:
MSKGLLLLWLVTELWWLYLTPAASEDTIIGFLGQPVTLPCHYLSWSQSRNSMCWGKGSCPNSKCNAELLRTDGTRIISRKSTKYTLLGKVQFGEVSLTISNTNRGDSGVYCCRIEVPGWFNDVKKNVRLELRRATTTKKPTTTTRPTTTPYVTTTTPELLPTTVMTTSVLPTTTPPQTLATTAFSTAVTTCPSTTPGSFSQETTKGSAFTTESETLPASNHSQRSMMTISTDIAVLRPTGSNPGILPSTSQLTTQKTTLTTSESLQKTTKSHQINSRQTILIIACCVGFVLMVLLFLAFLLRGKVTGANCLQRHKRPDNTEDSDSVLNDMSHGRDDEDGIFTL
Protein: Thrombomodulin (O35370)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Prothrombin
- Vitamin K-dependent protein C
- Endothelial protein C receptor
- Tissue factor
- Tissue factor pathway inhibitor
- Tissue factor pathway inhibitor
- Urokinase-type plasminogen activator
- Proteinase-activated receptor 1
- Coagulation factor VII
- Complement factor H
Sequence:
MLGVFLLGVLAPAGLGISALAKLQPKGSQCVGNECFALFQDPVTFLDASQACQRLQGHLMTVRSSVAADVISLLVSDSSMDSRPWIGLQLPQGCGDPVHLGPLRGFQWVTGDNHTSYSRWARPNDQSPPLCGPLCVTVSTATEAAPGEPAWEEKPCENETKGFLCEFYFAAFCRPLRVNTRDPEGAHISSTYNTPLGVSGADFQTLPIGSSATVAPFGLELVCRALPGTSEGHWTREVTGAWNCSVENGGCEYMCNRSANGPRCVCPSGGDLQADGRSCAKPVAQLCNELCQHFCVNNSDVPGSYSCMCETGYQLAADGHRCEDVDDCKQGPNPCPQLCSNTEGGFECRCYDGYELVDGECVEQLDPCFRSKCEYQCQPVNSTHYNCICAEGFAPKLDDPDRCEMFCNETSCPADCDPNSPSFCQCPEGFILDEGSICTDIDECSQGECLTNECRNLPGSYECICGPDTALAGQISKDCDPIPVLEDSEDGGSGEHPSSNPTVVSSTVPPSARPMHSGVLIGISIASLSLVVALLALLCHLRKKQGTARAELEYKCTSSAKEVVLQHVRTDRTLQKF
Protein: Cytochrome b6-f complex subunit 6 (Cytochrome b6-f complex subunit PetL) (Cytochrome b6-f complex subunit VI) (P0C393)
Organism: Oryza sativa (Rice)
Function: Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex (By similarity).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MLTITSYFGFLLAALTLTLALFIGLNKIRLI
Protein: Jasmonoyl--L-amino acid synthetase JAR4 (EC 6.3.2.52) (Jasmonate-amino acid synthetase JAR4) (Jasmonic acid-amido synthetase JAR4) (Protein JASMONATE RESISTANT 4) (A0A1J6KGJ9)
Organism: Nicotiana attenuata (Coyote tobacco)
Function: Catalyzes the synthesis of jasmonate-amino acid conjugates by adenylation. Catalyzes the conjugation of jasmonate (JA) to Ile, Leu and Val. Catalyzes the conjugation of jasmonate (JA) to Ile to mediate defense signaling and resistance to the herbivore Manduca sexta caterpillars.
Interaction partners:
- Jasmonoyl--L-amino acid synthetase JAR6
- Jasmonic acid-amido synthetase jar1
Sequence:
MKMVVEKTEKFDPEEVIEEFEVLTKDAGKIQEETLQKILEENGGTEYLQQWGLNGKTDSLSFKNCIPIVTHKDLEPYIHRIADGDLSPILTGKPITTISLSSGTTQGKPKFVPFNEELMESTMQIFKTSFVFRNREFPVVNGKALQFIYGSKQFKTKGGLAAGTATTNVYRNAQFKKTMKAMQTPCCSPDEVIFGPDFQQSLYCHLLCGLIFRDEVQVVSSTFAHSIVHAFRNFEQIWQELVTNIREGVLSSRVIVPSMRAAMSKLLKPDPELADTIFNKCSRLSNWYGLIPELFPNTRYIYGIMTGSMEPYLKKLRHYAGDLPLLSADYGSSEGWIGANVNPELPPELVTYAVLPNIGYFEFIPLMENLDGLEPMPVGLTEVKLGEEYEIVVTNFAGLYRYRLGDVVKIKGFHNGTPELQFICRRNLLLSINIDKNTEKDLQLAVEAAAKILSDEKLEVVDFTSHVNVSADPGHYVIFWELNGEASEEILKECCNCLDKSFVDAGYVGSRKVHAIGALELRIVKRGTFHKILDHFVGLGAAVSQFKTPRCVGPTNLSVLQILSSNVVESYFSTAFC
Protein: 2-methylisocitrate lyase (2-MIC) (MICL) (EC 4.1.3.30) ((2R,3S)-2-methylisocitrate lyase) (Q937P0)
Organism: Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha)
Function: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
Interaction partners:
Sequence:
MTYSASDLARSAGARFRQALADEHPLQVVGTINANHALLAKRAGYRAIYLSGGGVAAGSLGLPDLGISNLDDVLTDIRRITDVCDTPLLVDVDTGFGASAFNVARTTKSLIKFGAAAMHIEDQVGAKRCGHRPNKEIVTQGEMVDRIRAAVDARTDENFVIMARTDALAVEGLDKAIERAVACAEAGADAIFPEAMTDLAMYRKFVDAVKVPVLANITEFGATPLFTTEELDGAGVSMVLLPLSAFRAMNKAAENVYAAIRQDGTQKNVVDTMQTRAELYESIGYHDFEQKLDALFAQGKGK
Protein: Calcium/calmodulin-dependent protein kinase type II alpha chain (CaM-kinase II alpha chain) (EC 2.7.11.17) (Q00168)
Organism: Drosophila melanogaster (Fruit fly)
Function: A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels.
Interaction partners:
- Potassium voltage-gated channel protein eag
- Phosrestin-1
- AT10229p
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- NMDA receptor 2, isoform C
- FI17352p1
- Ubiquitin-related modifier 1 homolog
- Glutamate [NMDA] receptor subunit 1
- Discs large 5, isoform A
Sequence:
MAAPAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKESTDSSSTTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQNIGNSQCSSARRQEIIKITEQLIEAINSGDFDGYTKICDPHLTAFEPEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAACIAYVRLTQYIDKQGHAHTHQSEETRVWHKRDNKWQNVHFHRSASAKISGATTFDFIPQK
Protein: Gnb1l protein (Guanine nucleotide binding protein (G protein), beta polypeptide 1, like) (Guanine nucleotide binding protein (G protein), beta polypeptide 1b isoform X1) (Guanine nucleotide-binding protein (G protein), beta polypeptide 1b) (Q803H5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Guanine nucleotide-binding protein subunit gamma
- Cone transducin alpha subunit, alpha transducing activity polypeptide 2) subunit alpha-2)
- Regulator of G-protein signaling 9a
- Guanine nucleotide-binding protein
- Guanine nucleotide-binding protein subunit gamma
- Regulator of G-protein signaling 9
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein G
- Rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Sequence:
MSELDQLRQEAEQLKNQIRDARKACADATLSQITANIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYSLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFAGHTGDVMSLSLAPDTRLFVSGACDASAKLWDIREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMVYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Protein: Alpha-amylase inhibitor 0.28 (CIII) (WMAI-1) (P01083)
Organism: Triticum aestivum (Wheat)
Function: Alpha-amylase inhibitor.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MWMKTVFWGLLVFMLVATTMAVEYGARSHNSGPWSWCNPATGYKVSALTGCRAMVKLQCVGSQVPEAVLRDCCQQLADINNEWCRCGDLSSMLRSVYQELGVREGKEVLPGCRKEVMKLTAASVPEVCKVPIPNPSGDRAGVCYGDWAAYPDV
Protein: Inner kinetochore subunit fta4 (Constitutive centromere-associated network protein fta4) (Sim4 complex subunit fta4) (Sim4-mal2-associated protein 4) (O94716)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere.
Subcellular location: Nucleus. Chromosome, centromere, kinetochore.
Interaction partners:
- Inner kinetochore subunit cnl2
- Inner kinetochore subunit fta3
- Inner kinetochore subunit fta7
- Inner kinetochore subunit fta6
- Inner kinetochore subunit fta2
- Inner kinetochore subunit fta1
- Inner kinetochore subunit mal2
- Inner kinetochore subunit mis15
- Inner kinetochore subunit mis17
- Inner kinetochore subunit mis6
Sequence:
MDIYEHKKSFMERQIRLLNRPMRPPKDWKLPLKSGQLSESVVETVFQRLQLRIQKHAKLNYSHQATQHVAAQIRKLYEQNSAIEDITFLNPLFYGEIDLSNLDSVKSLPHPWPFQKESRPVEKDEEQEKFNRLTGELLGLLTTLSELEQERSELEQIEKMLEPFEDGPSSIHTNMWKKNPELISTLNSTNTMVAKINSLLRGVSFPSLNNDNQEASLEDEIRSQLFEKTISDD
Protein: DNA mismatch repair protein (D4A0U9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- DNA mismatch repair protein Msh2
- Mismatch repair endonuclease PMS2
- DNA mismatch repair protein Mlh1
- DNA mismatch repair protein
- Proliferating cell nuclear antigen
- PMS1 homolog 1, mismatch repair system component
- DNA polymerase delta catalytic subunit
- Exonuclease 1
- MutL homolog 3
- Serine-protein kinase ATM
Sequence:
MLLEMFLESYSDLPEASKGVLLNESFLKIVYLRVIAFEVRYPNTNWHIYIFIFILFCSSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIRKNGKSARVHVQFFDDSPTRGWVSKRMLKPYTGSKSKEAQKGGHFYSSKSEILRAMQRADEALSKDKAQRLELAVCDEPSEPEEEEEEEEEETQVHGAYLSDKSEEENQDESEEETQPNAQGPRRSSRQVKKRRVISDSESDIGGSDVEFKPDSKQEGSSDEVSSGVGDSDSEGLGSFGKGAPKRKRTVAAHGGLKRKSLKKETGSAKQATRILSETKSTLSAFCAPQNSESQTHVCGGGNDSSGPTIWYHETLEWLKPEKRRDENRRRPDHPDYNSSTLYVPEDFLNSCTPGMRRWWQFKSQNFDLVIFYKVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPEIAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQTYSVLDGDPSENYSRYLLSLKEKEEDSSGHMRAYGVCFVDTSLGKFFLGQFSDDRHCSRLRTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGSQFWDATKTLRTLLEGGYFTGNEGSGAELPPVLKAMTSESDSVGLTPGEESELSLSALGGCVFYLKKCLIDQELLSMANFEEYFPLDSDMVGTVKPGAVFTKASQRMVLDAVTLSNLEIFLNGTNGSTEGTLLERLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAIEDLMAVPDKVAEVADLLKKLPDLERLLSKIHNVGSPLKSQNHPDTRAIMYEETTYSKKKIIDFLSALEGFKVMCKITRLMEDVADGFKSKTLKQVVTLQTKSPKGRFPDLTAELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLDKQRSRIGCRNIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTKKGCKRYWTKVIEKKLSNLINAEERRDASLKDCMRRLFYNFDKNHKDWQSAVECTAVLDVLLCLASYSQGGDGPMCRPVLLLPGEDTHPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEDAEADGKAYCVLVTGPNMGGKSTLIRQAGLLAVMAQMGCYVPAELCRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILRHATAHSLVLVDELGRGTATFDGTAIASAVVKELAETIKCRTLFSTHYHSLVEDYSKNVCVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFERMNQALQLFREVCLASERPTVNSEAIHRLLALVNQL
Protein: Resistin (Q762I5)
Organism: Bos taurus (Bovine)
Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Adiponectin
- Leptin
- Toll-like receptor 4
- Tumor necrosis factor
- Insulin
- Interleukin-1 beta
- Interleukin-6
- Appetite-regulating hormone
- Adiponectin receptor 2
- Adenylyl cyclase-associated protein 1
Sequence:
MKALSFLFIPVLGLLVCGQSLCPIDKAISEKIQEVTTSLVPGAVRIIGLDCRSVTSRGSLVTCPSGFAVTGCTCGSACGSWDVRAETTCHCQCAGMDWTGARCCRLHIQ
Protein: Doublesex and mab-3 related transcription factor 3, truncated (Duplex and mab-3 related transcription factor 3 allele A) (J7FCF0)
Organism: Equus caballus (Horse)
Function: Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Interaction partners:
Sequence:
MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAAAAAPQPPPTSQPSQPPPPQRPAAELAAAAALRWATEPQPGALQAQLAKPDLTEERLGDGSSADNTETFSDKDTDQRSSPDVVKSKGCFTPESPEVVSVDEGGYAVQKNGGTSESRPDSPKYHGEQNHLLIEGPSGTVSLPFSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSASAADRT
Protein: AP-2 complex subunit sigma (Adaptor AP-2 17 kDa protein) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Sigma2-adaptin) (Q84WL9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The complex binds polyphosphoinositides (By similarity).
Subcellular location: Cell membrane. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.
Interaction partners:
- AP-2 complex subunit mu
- AP-2 complex subunit alpha-2
- AP-2 complex subunit alpha-1
- Beta-adaptin-like protein B
- At5g57460
- Calcium sensing receptor, chloroplastic
- Beta-adaptin-like protein C
- Calcium-binding EF hand family protein
- Beta-adaptin-like protein A
- Clathrin heavy chain 1
Sequence:
MIRFILLQNRQGKTRLAKYYVPLEESEKHKVEYEVHRLVVNRDAKFTNFVEFRTHKVIYRRYAGLFFSVCVDITDNELAYLESIHLFVEILDHFFSNVCELDLVFNFHKVYLILDEFILAGELQETSKRAIIERMSELEKLQ
Protein: Pollen receptor-like kinase 3 (AtPRK3) (EC 2.7.11.1) (Q9M1L7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor-like kinase involved in the control of pollen germination and pollen tube polar growth. Can phosphorylate ROPGEF1 in vitro.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein LURE 1.1
- Protein LURE 1.2
- Protein LURE 1.3
- Protein LURE 1.5
- Protein LURE 1.4
- CRIB domain-containing protein RIC5
- Immunoglobulin E-set superfamily protein
- At1g12070
Sequence:
MTAVLFLCFLLICFSFTPSLQNVSESEPLVRFKRSVNITKGDLNSWRTGTDPCNGKWFGIYCQKGQTVSGIHVTRLGLSGTINIEDLKDLPNLRTIRLDNNLLSGPLPPFFKLPGLKSLLLSNNSFSGEIADDFFKETPQLKRVFLDNNRLSGKIPASLMQLAGLEELHMQGNQFTGEIPPLTDGNKVLKSLDLSNNDLEGEIPITISDRKNLEMKFEGNQRLCGSPLNIECDEKPSSTGSGNEKNNTAKAIFMVILFLLIFLFVVAIITRWKKKRQPEFRMLGKDHLSDQESVEVRVPDSIKKPIDSSKKRSNAEGSSKKGSSHNGKGAGGGPGSGMGDIIMVNSEKGSFGLPDLMKAAAEVLGNGSLGSAYKAVMANGLSVVVKRIRDMNKLAREAFDTEMQRFGKLRHPNVLTPLAYHYRREEKLVVSEYMPKSSLLYVLHGDRGVYHSELTWATRLKIIQGVARGMDFLHEEFASYDLPHGNLKSSNVLLSETYEPLISDYAFLPLLQPNNASQALFAFKSPEFVQNQQVSPKSDVYCLGIIVLEVMTGKFPSQYLNTGKGGTDIVEWVQSSIAQHKEEELIDPEIASNTDSIKQMVELLRIGAACIASNPNERQNMKEIVRRIERVTL
Protein: Hexosyltransferase (EC 2.4.1.-) (A1Z863)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000256|ARBA:ARBA00004447, ECO:0000256|RuleBase:RU364016}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004447, ECO:0000256|RuleBase:RU364016}.
Interaction partners:
- Hexosyltransferase
- Hexosyltransferase
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I
Sequence:
MHNSLVTKLLLRLLLLFALLTGASIVVLTKCGFDELTTRETQANNPSESSGFSYTLSEREAEIERLKQEVLALRTQILFLQNNRSTAKPSNGSLQLQETTAGPPTAPLGHHYDCSSYIRKQVGAAEILHGLPLNNEYELIPYNHFTFTRVYPIDLGLGKRVVEKPIGYRRRDLIEAVNKALESLNRNHSARIRAKGAGSAAAYASDVIKYTLDDFIEGIYRNEPTTGTQYELYFQSVKHQASPVRRALVMRPFAPLQTVQLSELSSSVDNSGAPPSHSPPIIHVILPLAGRLHSFRGFLQMFAKLEDRRLELIVVYFGTSGLEQARSLAGRSQRTQFLALNETFSRAKALRLGAEHIQPAEEDVLLFMCDVDIMFTTKFLERCRWNAAPGKKVYYPVVFSLYNPHVVYSLQGKPLPSEEEQLVISRDTGFWRDFGYGMTCQYRSNFLKVRGFDEEEIVGWGGEDVMLYRKYVRSKIKIIRATDPGIFHRWHTKICSSSLTADQYRACIRSRALNEASHAQLGFLAFRDDIAAANAAKMTS
Protein: Cold-regulated 413 plasma membrane protein 2 (AtCOR413-PM2) (Q9SVL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MGRMDYLAMKTDDVDTVALVNSDMEELKVAAKKLFSDVSKLGGLGFGVSFLKFLASFAAIYLLILDRTNWKTKMLTSLLIPYIFLSLPSVIFNFLSGDVGKWIAFVAVVLRLFFPKHFPDWLEMPGSLILLLVVSPHFLAHHIRGTWIGTVISLFIGCYLLQEHIRASGGFRNSFTQPRGVSNTLGIILLLVYPVWALIVRVM