wanglab/gogpt-training-data huggingface dataset:
Protein: Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A) (Q8NE86)
Organism: Homo sapiens (Human)
Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:23755363, ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:27099988, ECO:0000305|PubMed:26341627, ECO:0000305|PubMed:31080062}; Multi-pass membrane protein {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:31080062, ECO:0000269|PubMed:32494073, ECO:0000269|PubMed:32762847, ECO:0000269|PubMed:32862359}.
Interaction partners:
- Calcium uptake protein 1, mitochondrial
- Calcium uptake protein 2, mitochondrial
- Essential MCU regulator, mitochondrial
- Calcium uniporter regulatory subunit MCUb, mitochondrial
- Calcium uptake protein 3, mitochondrial
- Mitochondrial calcium uniporter regulator 1
- Non-selective voltage-gated ion channel VDAC1
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- Stress-70 protein, mitochondrial
Sequence:
MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQNLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD
Protein: Oye32p (A0A1D8PMP0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- enoyl-[acyl-carrier-protein] reductase
- Fumarate reductase
- Fumarate reductase
- Cip1p
- Gst2p
- Enoyl reductase
- Probable quinone oxidoreductase
- glutathione transferase
- Probable NADPH dehydrogenase
- Gre2p
Sequence:
MTVPYQVKPSDEIKGAPEVSYYTPEQPVPAGTFYPQSSDEVAPKIFQPLKIGKLALPNRIGVSPMCQYSADYNFEATPYHLIHYGSLVNRGPGITIVESTAVSPEGGLSPHDLGIWKDEQAEKLKPIVDYAHSQKQLIAIQLGHGGRKASGQPLFLHLEQVADKSVNGFADKAVAPSALAFRPNGNLPVPNELTKDEIKRVVKDFGAAARRAVEISGFDAVEIHGAHGYLINEFYSPISNKRTDEYGGSFENRTKFLKEVIDSVKSSIPNDVPVFLRISAAENSPDPEAWTIEDSKKLADILVEKGIALVDVSSGGNDYRQPPRSGISKELREPIHVPLSRAIKQHVGDKLLVSCVGGLEKDPELLNKYLEEGTFDLALIGRGFLRNPGLVWEFADKLGVRLHQALQLGWGFWPNKQQIVDLIERTSKLEVN
Protein: Muscle LIM protein 1 (P53777)
Organism: Drosophila melanogaster (Fruit fly)
Function: Positive regulator of myogenesis.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Stretchin-Mlck, isoform U
- Flightin
Sequence:
MPFVPVETPKCPACGKSVYAAEERVAGGYKFHKTCFKCSMCNKALDSTNCTEHEKELFCKNCHGRKYGPKGYGFGGGAGCLSTDTGAHLNRE
Protein: Putative eukaryotic translation initiation factor (Q4Q813)
Organism: Leishmania major
Interaction partners:
- Probable eukaryotic initiation factor 4A
- Putative eukaryotic initiation factor 4a
- Putative eukaryotic translation initiation factor 4 gamma
- Putative eukaryotic initiation factor 4a
- Putative eukaryotic initiation factor 4a
- Putative eukaryotic translation initation factor 4 gamma
- Probable eukaryotic initiation factor 4A
- Putative eukaryotic translation initiation factor 5
Sequence:
MNPSAAAYIPQQSDAKGDPKSSSAAAVAKPPSTQPATKLSAAAEPFVPGGPKQMSATSTHVDPKATTEDEKTTAPLLMECPASSLPDSAAAAGAAKKEADENDDSQLDWLPEAQPTDWSESKLPKLFGCHNTAAKATSSAIPLHASWDLYADDHQGSSNMASNSSPTSTMSFEPIFVSNVGDVESFWRLWRYLPAPSALPTVYTYSWFRKDIKPEWEHPRNKKGGTISIVVFDRDRSGLSDKQVLDDVFMAMLVGAVGESFHECSTTLNGIMLKVRSNKPVTLQLWTAHSEVGKLKAFANSVRDTLTKIMGAKTLQKLEYYSHHQKQAATNSLAARMKGKTKISPDHTF
Protein: Sensor protein CreC (EC 2.7.13.3) (P08401)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane-associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Transcriptional regulatory protein CreB
- Protein CreA
- Inner membrane protein CreD
- Phosphate regulon transcriptional regulatory protein PhoB
- Aerobic respiration control sensor protein ArcB
- Transcriptional regulatory protein BaeR
- Transcriptional regulatory protein BasR
Sequence:
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSGDPTHGQLAQAFNQLQHRPFRANIGGINKVRNEYHVYMTDAQGKVLFDSANKAVGQDYSRWNDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRLIGVLSVGKPNAAMAPVIKRSERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLAQALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQNARMQALVETLLRQARLENRQEVVLTAVDVAALFRRVSEARTVQLAEKKITLHVTPTEVNVAAEPALLEQALGNLLDNAIDFTPESGCITLSAEVDQEHVTLKVLDTGSGIPDYALSRIFERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
Protein: Large ribosomal subunit protein P1B (60S acidic ribosomal protein P1-alpha 3) (A3) (P17477)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays an important role in the elongation step of protein synthesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL18A
Sequence:
MSASELATSYSALILADEGIEITSDKLLSLTKAANVDVEPIWATIFAKALEGKDLKELLLNIGSAAAAPAAGGAGAPAAAAGGEAAAEEQKEEAKEEEESDEDMGFGLFD
Protein: Large ribosomal subunit protein eL19B (60S ribosomal protein L19-B) (O42699)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL29
Sequence:
MANLRTQKRLAASVLKCGKRKVWMDPNEISEISNANSRQNIRKLVKDGLVIRKPNLMHSRFRIRKTHAAKRLGRHTGYGKRKGTAEARMPSTVVWMRRQRVLRRLLRKYRESGKIDKHLYHTLYLEAKGNTFKHKRALIEHIQRAKAEANRTKLIQEQQDARRARAKAARQRRAKAVEEKREQIYTAAEKIEE
Protein: Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Q9P275)
Organism: Homo sapiens (Human)
Function: Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:36912080}. Cytoplasm {ECO:0000269|PubMed:27445338}.
Interaction partners:
- ATP-dependent RNA helicase DHX33
- Zinc finger-containing ubiquitin peptidase 1
- U3 small nucleolar RNA-associated protein 14 homolog A
- Myc proto-oncogene protein
Sequence:
MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTYESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKRQDSGTMKKPHTTEEIGVPISRNGSTLGLKSQNGCIPPKLPSGSPSPKLSQTPTHMPTILDDPGKKVKKPAPPQHFSPRTAQGLPGTSNSNSSRSGSQRQGSWDSRDVVLSTSPKLLATATANGHGLKGNDESAGLDRRGSSSSSPEHSASSDSTKAPQTPRSGAAHLCDSQETNCSTAGHSKTPPSGADSKTVKLKSPVLSNTTTEPASTMSPPPAKKLALSAKKASTLWRATGNDLRPPPPSPSSDLTHPMKTSHPVVASTWPVHRARAVSPAPQSSSRLQPPFSPHPTLLSSTPKPPGTSEPRSCSSISTALPQVNEDLVSLPHQLPEASEPPQSPSEKRKKTFVGEPQRLGSETRLPQHIREATAAPHGKRKRKKKKRPEDTAASALQEGQTQRQPGSPMYRREGQAQLPAVRRQEDGTQPQVNGQQVGCVTDGHHASSRKRRRKGAEGLGEEGGLHQDPLRHSCSPMGDGDPEAMEESPRKKKKKKRKQETQRAVEEDGHLKCPRSAKPQDAVVPESSSCAPSANGWCPGDRMGLSQAPPVSWNGERESDVVQELLKYSSDKAYGRKVLTWDGKMSAVSQDAIEDSRQARTETVVDDWDEEFDRGKEKKIKKFKREKRRNFNAFQKLQTRRNFWSVTHPAKAASLSYRR
Protein: At5g64360 (Chaperone DnaJ-domain superfamily protein) (Emb|CAB89376.1) (Q9FMF3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- DnaJ domain protein
- Protein EMBRYONIC FLOWER 1
- Chaperone protein dnaJ 3
- Ubiquitin-conjugating enzyme E2 29
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1
- E3 ubiquitin-protein ligase RMA3
Sequence:
MVGGRGGVGGGGGNRVEADQWLVTSEKLLASSDLQGAKTFAIRACEADPTRAEAADYILAICDILLAGETRLGDSNLPDWYAVLRLGRLAQNPEHVATQYRRLALLLNPSVNRLPFADRALKIVSDAWFVLSDPFKKSFYDRELQLSQLGQSGFHPQTQSHQNFQWEPSSSTAVYPPPRSQSQAGTSADPMATSFWTACPYCFVLFEYPKAYEECTLKCQECRRAFQAVTIPKPPVDKKDDEDVYFCSWALFPLGFSGEFQAPSWSPISPLFACPLQKLDGEPKKRKEPGPPRIYYDDDDIYVAISDGDDAGDDGDWQDVVQVNKKTNVGKGKETYVRSNKKHGVEEVQNVESISSASNHAVSIASNAAAVGSSTGVMSKPGSYITRKRMGTGAKNLGRLDLNVEFSNEVEEPGVAGGGNAGNGIGSNREVDNMEGIGFFEGLDEFLNSLPILSVVGDDKIKAT
Protein: 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Q9DAK9)
Organism: Mus musculus (Mouse)
Function: Exhibits phosphohistidine phosphatase activity.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Intermediate conductance calcium-activated potassium channel protein 4
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6
- Nucleoside diphosphate kinase B
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
- Large ribosomal subunit protein mL41
Sequence:
MAADLGQIPDVDIDSDGVFKYVLIRVHLAEPSGDPAKECKEIVRGYKWAEYHADIYDKVSGELQRNGYDCECLGGGRISHQSQDRKIHVYGYSMGYGRAQHSVSTEKIKAKYPDYEVTWADDGY
Protein: ADP-ribosylation factor GTPase-activating protein AGD5 (ARF GAP AGD5) (Protein ARF-GAP DOMAIN 5) (AtAGD5) (Protein MODIFIED TRANSPORT TO THE VACUOLE 4) (Protein NEVERSHED) (Protein ZIGA3) (Q9FL69)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTPase-activating protein (GAP) for ADP ribosylation factor (ARF). Mediates clathrin-dependent trafficking of vacuolar cargo from the trans-Golgi network (TGN). Promotes plant growth. Involved in the regulation of membrane trafficking and cell separation during floral organ shedding and abscission. Prevents abscission zone (AZ) cells enlargement. Exhibits ARF-GTPase activity toward ARF1 at TGN.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19429787, ECO:0000269|PubMed:21105926, ECO:0000269|PubMed:23771894}. Endosome {ECO:0000269|PubMed:19429787}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:23771894}. Note=Colocalizes with AGD5 at the trans-Golgi network (TGN) (PubMed:21105926). Colocalizes with clathrin at the TGN (PubMed:23771894). {ECO:0000269|PubMed:21105926, ECO:0000269|PubMed:23771894}.
Interaction partners:
- Receptor-like protein kinase 5
- ADP-ribosylation factor GTPase-activating protein
- LRR receptor-like serine/threonine-protein kinase HSL2
- Protein MODIFIED TRANSPORT TO THE VACUOLE 1
- Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
- Somatic embryogenesis receptor kinase 1
Sequence:
MNEKANVSKELNARHRKILEGLLKHPENRECADCKTKGPRWASVNLGIFICMQCSGIHRSLGVHISKVRSATLDTWLPEQVAFIQSMGNDKANSYWEAELPPNYDRVGIENFIRAKYEEKRWVSRGEKARSPPRVEQERRKSVERSGPGYEHGHSSSPVNLFEERKTIPASRTRNNVAATRINLPVPPQGPSQVIKPQQKMESAATPVEREKQAVNVAPASDPPKVDFATDLFNMLSMDDSTTNTSEATPGDTPADDNSWAGFQSAGSGQTAEKIVTAKPAESSSPPASSSDFEDLFKDTPNLTTQQAPKDVKGDIMSLFEKTNIVSPFAMHQQQVAMLAQQQALYMAAAKAAGGTPNGVNQQAIANALNVASANWSNPGGYQIPGMTNPVGGQADLQKLMQNMNMNANMNTRPAQPQENTLQYPSSSFYTMGQANQVNGMTPNSTGKPQSSSATQPTSTTPSSQSGKDFDFSSLMDGMFTKH
Protein: Autophagy-related 1, isoform B (LD18893p) (Q8MQJ7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Autophagy-related protein 13 homolog
- Autophagy-related 14
- Beclin-1-like protein
- Autophagy-related protein 2
- Autophagy-related protein 101
- RB1-inducible coiled-coil protein 1
- Autophagy protein 5
- Cysteine protease
- Ubiquitin-like-conjugating enzyme ATG3
- Phosphatidylinositol 3-kinase catalytic subunit type 3
Sequence:
MNIVGEYEYSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCITKKGQLKTQNLLGKEIKILKELTELHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNSKDRISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAKAKSPLQQQLEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNSGSCSSHEDSDDFVLVPKNLPEDQRQGLAQVQAQPASGGQRPQQQQNQSSPPRPSSLPISEPKPVPAPARRQVARPGPLTVATLGGQQIPRSQPISVKQPRPDQRKSSVSSDINSISPPAVQFAIGTPPTRMRSASGGSLSETPPPHAPSTWQVSPGHSQSPLRRSGNSSPVLPSAALTKLPTLGSPTMLVAPGSLGSIGSAGSGSENNNQHHMLGPRAFTLPELGATGGLHSLLDTGAGGGGEPHAFQAPELSEETLMDREHNETLSKLNFVLALTDCIQEVADSRCAPLSTFMVAGSQSAAQAASADAQQIPPHAPEHCKRAERLVLLVRGLQLLSSGMNLASQQLSNGQLKPSSNVKNALLTMNAKYRSMLFESKRLNGSGLLQKANAFNITADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHILLHSLVQKCNHPQDKMMLNKYRDAVEKRLSILQQHGYIYMTDENA
Protein: Putative melanoma-associated antigen 5P (Cancer/testis antigen 1.5) (CT1.5) (MAGE family member A5 pseudogene) (MAGE-5 antigen) (P43359)
Organism: Homo sapiens (Human)
Function: May negatively regulates apoptosis.
Interaction partners:
Sequence:
MSLEQKSQHCKPEEGLDTQEEALGLVGVQAATTEEQEAVSSSSPLVPGTLGEVPAAGSPGPLKSPQGASAIPTAIDFTLWRQSIKGSSNQEEEGPSTSPDPESVFRAALSKKVADLIHFLLLKY
Protein: Small ribosomal subunit protein mS42 (37S ribosomal protein S26, mitochondrial) (P47141)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein uS17m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein mS23
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein uS4m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein mS35
Sequence:
MLVFKRGIHVVPKLPNSKALLQNGVPNILSSSGFKTVWFDYQRYLCDKLTLATAGQSLESYYPFHILLKTAGNPLQSNIFNLASSIHNNHLFVENILPSAVEHGTNSNAVVKTEPSRLFLSKIKDSFNGSDWEVVKEEMIYRAENEVLGQGWLFLVENNEKKLFILTSNNNGTPYYFPRNQSFDLNSAISIDEFATLKQMKELIGKSTKLNGKVQDWTMPIICVNLWDHAYLHDYGVGNRSKYVKNVLDNLNWSVVNNRIFSGISK
Protein: Isoflavone reductase homolog A622 (NsA622) (EC 1.3.1.-) (Q76LW3)
Organism: Nicotiana sylvestris (Wood tobacco) (South American tobacco)
Function: NADPH-binding protein. Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (By similarity). Reductase involved in a late step of tobacco alkaloid biosynthesis (By similarity). Triggers either the formation of a nicotinic acid-derived precursor or the final condensation reaction of tobacco alkaloids (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12369619}.
Interaction partners:
Sequence:
MVVSEKSKILIIGGTGYIGKYLVETSAKSGHPTFALIRESTLKNPEKSKLIDTFKSYGVTLLFGDISNQESLLKAIKQVDVVISTVGGQQFTDQVNIIKAIKEAGNIKRFLPSEFGFDVDHARAIEPAASLFALKVRIRRMIEAEGIPYTYVICNWFADFFLPNLGQLEAKTPPRDKVVIFGDGNPKAIYVKEEDIATYTIEAVDDPRTLNKTLHMRPPANILSFNEIVSLWEDKIGKTLEKLYLSEEDILQIVQEGPLPLRTNLAICHSVFVNGDSANFEVQPPTGVEATELYPKVKYTTVDEFYNKFV
Protein: Repulsive guidance molecule B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON) (Q7TQ33)
Organism: Mus musculus (Mouse)
Function: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15890774}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15890774}. Membrane raft {ECO:0000269|PubMed:15890774}.
Interaction partners:
- Neogenin
- Programmed cell death 1 ligand 2
- Bone morphogenetic protein 2
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein receptor type-1B
- Activin receptor type-1
- Repulsive guidance molecule A
- Netrin-1
- Growth/differentiation factor 5
Sequence:
MGVRAAPSCAAAPAAAGAEQSRRPGLWPPSPPPPLLLLLLLSLGLLHAGDCQQPTQCRIQKCTTDFVALTAHLNSAADGFDSEFCKALRAYAGCTQRTSKACRGNLVYHSAVLGISDLMSQRNCSKDGPTSSTNPEVTHDPCNYHSHGGVREHGGGDQRPPNYLFCGLFGDPHLRTFKDHFQTCKVEGAWPLIDNNYLSVQVTNVPVVPGSSATATNKVTIIFKAQHECTDQKVYQAVTDDLPAAFVDGTTSGGDGDVKSLHIVEKESGRYVEMHARYIGTTVFVRQLGRYLTLAIRMPEDLAMSYEESQDLQLCVNGCPMSECIDDGQGQVSAILGHSLPHTTSVQAWPGYTLETASTQCHEKMPVKDIYFQSCVFDLLTTGDANFTAAAHSALEDVEALHPRKERWHIFPSSCGGCRDLPVGLGLTCLILIMFL
Protein: SWI/SNF and RSC complexes subunit ssr1 (O13788)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Chromatin structure-remodeling complex subunit sfh1
- Chromatin structure-remodeling complex subunit snf21
- SWI/SNF and RSC complexes subunit ssr3
- Chromatin structure-remodeling complex subunit rsc7
- Chromatin structure-remodeling complex subunit rsc9
- Chromatin structure-remodeling complex subunit rsc1
- Chromatin structure-remodeling complex subunit rsc58
- SWI/SNF chromatin-remodeling complex subunit snf5
- SWI/SNF and RSC complexes subunit arp9
- Chromatin structure-remodeling complex subunit rsc4
Sequence:
MSNVTENKHDLHENGVPDSAQPMELDVSKKEDTEPEVRDEAKEFLLSQLPQVEVPEWAQWFDFSKVHEIEKKQNPEFFDGKNTSKTPEVYKEYRDFMISTFRLNSKVYLTFTACRRNLAGDVCAVLRVHRFLEQWGLINYNVNPDTRPSKIGPPSTSHFQILADTPRGLVPLLPPPSSSIPRSKAVTIEDPSIVRTNIYDPSLDDVLKGKGSTPNQKPSLSNLHENNIDQSDSPQHCYCCGNKFNESYYQSQTAQKYNVCISCYQQNRFPSPTTIADYKEVAIQNKIEDDDTWTAQELVLLSEGVEMYSDDWAKVASHVNTKSVEECILKFLNLPSSDKALFKMDKVHTNPVVDSLQGKNPILSVVSFLAKMVPPSSFTQKSSAKEEESDKVKGESVYPKPESESYDVEMNGKSLEDSDSLSELYLTNEEKKMASIIKDSVNVQIKLIESKLSHFDYLDQHIRLKSQELDAFAQATYREKLYMKRECQNARKKIEQQLQSKDTAANGLPVQSSAETSVIPASSMSPS
Protein: Heat shock transcription factor 4 (H0YC39)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XVAVVQAILEGKGSFSPEGPRNAQQPEPGDPREIPDRGPLGLESGDRSPESLLPPMLLQPPQESVEPAGPLDVLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPALLRAGLPPTWARKPVPPPKTPRL
Protein: L-asparaginase 2-3 (EC 3.5.1.1) (L-asparaginase II) (L-asparagine amidohydrolase II) (ASP II) (P0CX78)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Secreted. Periplasm.
Interaction partners:
Sequence:
MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDAPEYAIGSGYLNPQKSRILLQLCLYSGYGMDQIRSVFSGVYGG