wanglab/gogpt-training-data huggingface dataset:
Protein: Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Rotamase D) (Q9CR16)
Organism: Mus musculus (Mouse)
Function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q08752}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q08752}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q08752}.
Interaction partners:
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- Non-selective voltage-gated ion channel VDAC1
- ADP/ATP translocase 1
- Prostaglandin E synthase 3
- Stress-induced-phosphoprotein 1
- Non-selective voltage-gated ion channel VDAC2
- ADP/ATP translocase 2
- ADP/ATP translocase 4
- Non-selective voltage-gated ion channel VDAC3
Sequence:
MSHASPAAKPSNSKNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGTGSTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGQVIKGLGVARTLENVEVNGEKPAKLCVIAECGELKEGDDWGIFPKDGSGDSHPDFPEDADIDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYAKVLRYVDSSKAVIEKADRSRLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALEMDPSNTKALYRKAQGWQGLKEYDQALADLKKAQEIAPGDKAIQAELLKVKQMIKAQKDKEKAVYAKMFA
Protein: JNK-interacting protein 1 (JIP-1) (APP-like-interacting protein 1) (APLIP1) (Protein eye developmental SP512) (Q9W0K0)
Organism: Drosophila melanogaster (Fruit fly)
Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Kinesin light chain
- RIM-binding protein, isoform F
- Dual specificity mitogen-activated protein kinase kinase hemipterous
- Stress-activated protein kinase JNK
- JNK-interacting protein 3
- SNAPIN protein homolog
- Huntingtin, isoform A
- Kinesin heavy chain
Sequence:
MADSEFEEFHRPIFEPHTIAGFGSGAGSKKNNPHAFYSLIPNDDLEDSHSSKSDGDGSDQEDGIGLVDHEPKMRQVEDDELGDGLKVTLSSDGSLDTNDSFNSHRHHPLNHQDAIGGFLGMDTSGLGGNSAPVTIGASTDLLAPNTAATRRRRKLPEIPKNKKSSILHLLGGSNFGSLADEFRNGGGGGIPPAVRSGQQRSFLSLKCGYLMDEDSSPDSERMQSLGDVDSGHSTAHSPNDFKSMSPQITSPVSQSPFPPPFGGVPFGQLEMLEATHRGLHKFVPRHHDEIELEIGDAIYVQKEAEDLWCEGVNLRTGRQGIFPSAYAVDLDYNEFDPTVQLVKKERYLLGYLGSVETLAHKGTGVVCQAVRKIVGEYGNSPTGQTCILEVSDQGLRMVDRSGPNQNKKDKKPCIDYFYSLKNVSFCAFHPRDHRFIGFITKHPTVQRFACHVFKGSESTRPVAEAVGRAFQRFYQKFIETAYPIEDIYIE
Protein: Endolysin LysH5 (D-alanyl-glycyl endopeptidase) (EC 3.4.22.-) (H5 endolysin) (LysH5) (N-acetylmuramoyl-L-alanine amidase) (EC 3.5.1.28) (B8QIR1)
Organism: Staphylococcus phage phiH5 (Bacteriophage phiH5)
Interaction partners:
Sequence:
MQAKLTKKEFIEWLKTSEGKQYNADGWYGFQCFDYANAGWKALFGLLLKGVGAKDIPFANNFDGLATVYQNTPDFLAQPGDMVVFGSNYGAGYGHVAWVIEATLDYIIVYEQNWLGGGWTDGVQQPGSGWEKVTRRQHAYDFPMWFIRPNFKSETAPRSVQSPTQASKKETAKPQPKAVELKIIKDVVKGYDLPKRGSNPNFIVIHNDAGSKGATAEAYRNGLVNAPLSRLEAGIAHSYVSGNTVWQALDESQVGWHTANQIGNKYGYGIEVCQSMGADNATFLKNEQATFQECARLLKKWGLPANRNTIRLHNEFTSTSCPHRSSVLHTGFDPVTRGLLPEDKRLQLKDYFIKQIRAYMDGKIPVATVSNDSSASSNTVKPVASAWKRNKYGTYYMEESARFTNGNQPITVRKVGPFLSCPVGYQFQPGGYCDYTEVMLQDGHVWVGYTWEGQRYYLPIRTWNGSAPPNQILGDLWGEIS
Protein: SET binding factor 1 (M0RAP5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
Sequence:
MARLADYFVLVAFGPHPRGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPERNPPTFFVAVLTDINSERHYCACLTFWEPVESTQEVMCTEDATEKEEEAHGGGQAQLSSTAPAQPGQLFAPKTLVLVSRLDHADVFRNSLGLIYTIHVEGLNVNLENVIGNLLTCTVPLAGGSQRTISLGAGDRQVIQTPLVDSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTVTVPECVHIPPLPEPLQSQTHNVLSMVLDPELELADLAFPPPTTSASSLKMQDKELRAVFLRLFAQLLQGYRWCLHIVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSERGVPYRSTDLFDELVAHEVARMRADENHPHRVLRHVQELAEQLYKNENPYPAVAMHKVQRPGEASHLRRTHRPFPRLDEGTVQWIVDQAAAKMQGAPPAVKAERRTTVPSGPPMTAILERCSGPHINSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRCLAHELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIAAALLPLVTAFCRKLSPGVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPSDGVSPTQETGEAQSQDDERSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSRLLRERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKVCTESGVTSDHLKGLHVMVPDIVQMHIETLEAVHRESKRLPPIQKPKLLRPRLLPGEECVLDGLRVYLLPDGREEGVGGSGGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRISVQTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYPPDIRATFAFTLGSALTPGRPPRVTKDKGPSFRTLSRNLVKNAKKTIGRQYVTRKKYNPPGWEHRGQPPPEDQEDEISVSEELEPSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSIQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNTPSPGQAQADSSSLEQEKYLQAVVSSMPRYADSSGRNTLSSFSSAHMGGHVPSPRARVTTLSNPLAASASRWTASRGKWSSVRASGRSSGLGADVGSRLAGRDLLSTPHTNGAPPDSGFLRPQRAALYIIGDKAQLKGVRPDPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPATEPSPASFLRSLEDSEWLIQIHKLLQISVLVVELLDSGSSVLVSLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHTSRRFRTFLLDSDYERIELGLLYEEKGERRGQLACKSVWEYVDRLSKRTPMFYNYTYAPEDTEVLRPYSNVSNLKVWDFYTEETLAEGPPYDWELAQGPPEPPEEERPDGGAPQSRRRVVWPCYDSRPRVQPDAISRLLEELQRLETELGRPSERWKETWDRVKAAQRLEGRQDGRGTPSSLLVSAVPHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSSSRQAARRSTSTLYSQFQTAESENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTIGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRIQSCLSDA
Protein: Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase) (P42125)
Organism: Mus musculus (Mouse)
Function: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P23965}.
Interaction partners:
- Trifunctional enzyme subunit beta, mitochondrial
- 3-ketoacyl-CoA thiolase, mitochondrial
- 2,4-dienoyl-CoA reductase [
- Enoyl-CoA delta isomerase 2
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Delta
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- Electron transfer flavoprotein subunit beta
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Sequence:
MALAAARRLLLHAGSRLGRREAVDGARRFANKRVLVETEGPAGVAVMKLRNPPVNSLSLECLTEFTISLEKLENDKSIRGVILTSECPGIFSAGLDLLEMYGRNPAHYAEYWKNVQELWLRLYTSNMILVSAINGASPAGGCLLALCCDYRVMADNPKYTIGLNESLLGIVAPFWFKDMYVNTIGHREAERALQLGTLFSPAEALKVGVVDEVVPEDQVHSKARSVMTKWLAIPDHSRQLTKNMMRKATADNLIKQREADIQNFTSFISKDSIQKSLHMYLEKLKQKKG
Protein: phosphatidate phosphatase (EC 3.1.3.4) (A0A0G2JW03)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAEKDPVCSSKWEAPRDKSSLDSAWSWIPIMRDPGWIRNVWPSNINVQTMNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPNGSLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMYLATSPILSEGASRMESQLKRNSVDRIRGLDPTTAAQGLPPSDTPSTGSLGKKRRKRRRKAHLDNLKRDDNVNTSEDEDMFPIEMSSDEDTALMDGSRALPNDVPPFQDDIPKENLPSISTYPQSASYPNSDREWSPSPSSLVDCQRTPPHLAEGVLSSSCPLQSCHFHASESPSGSRPSTPKSDSELVSKSADRLTPKNNLEMLWLWGELPQAAKSSSPHKMKDSSPLGGRKMADKIHFQTIHSESSDTFSDQSPTMARGLLIHQSKAQTEMQFVNEEDLEALGAAAPPLSVAEELKAPASSTAQTSSKSDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPGGLPKQASDNGARSANQSPQSVGSSGIDSGVESTSDSLRDLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFADNPAIIDDPNLVVKIGNKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNATIKEESKPEQGLPGKGHNTGEQPAQLGLTTRIKHESSSSDEEHSATKPSSSSHLSLLSNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSCDFPCSDTFSNFTFWREPLPPFENQDVHSASA
Protein: AT2G24420 protein (At2g24420/T28I24.15) (DNA repair ATPase-like protein) (Expressed protein) (Q9ZQ26)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
- Kunitz trypsin inhibitor 2
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- soluble epoxide hydrolase
- Dem-like protein
- Aminotransferase-like, plant mobile domain family protein
- Aminotransferase-like, mobile domain protein
- Aminotransferase-like, plant mobile domain family protein
- Plant mobile domain protein family
- Serine/threonine-protein phosphatase 7 long form-like protein
Sequence:
MAAAKLVALLLLLALVFNFTTCIFADAGIDGGDEPKLRSDGGDIELDQLNAKIRALESQIDDKTKELKGREELVTEKEKLLQERQDKVASLETEVSSLRKKGSSDSVELLSKAQARATELEKQVEVLKKFLEQKNKEKELIEAQTSETEKKLNELNSRVEKLHKTNEEQKNKIRKLERALKISEEEMLRTKHEATTKAKELMEVHGAWLPPWFAVHWSSFQTVAGTHWDAHGKPVMEKVTQKVTLAKNQAEKWAKPHMANVKTKYIPAIKETVKTHVEPHVQTLSTKAKEAYHASKSAVTPHIVKFQEHVDPYYQEAKKFSKPYVDQVATATKPHVDKVRATMKPYTTKTVHYYKEFLESASTYHHQLQANVESKLKSHELLEPFATKEFIWFAASALLALPIFIVYKFLCSLFCTKTKKPIRQSHQHTRRKARRGHSDK
Protein: NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) (BDH I) (Q04944)
Organism: Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W)
Interaction partners:
- NADH-dependent butanol dehydrogenase B
- GMP synthase
- Phosphate butyryltransferase
- Acetyl-CoA acetyltransferase
- Butyrate kinase 1
- Alcohol dehydrogenase
Sequence:
MLSFDYSIPTKVFFGKGKIDVIGEEIKKYGSRVLIVYGGGSIKRNGIYDRATAILKENNIAFYELSGVEPNPRITTVKKGIEICRENNVDLVLAIGGGSAIDCSKVIAAGVYYDGDTWDMVKDPSKITKVLPIASILTLSATGSEMDQIAVISNMETNEKLGVGHDDMRPKFSVLDPTYTFTVPKNQTAAGTADIMSHTFESYFSGVEGAYVQDGIAEAILRTCIKYGKIAMEKTDDYEARANLMWASSLAINGLLSLGKDRKWSCHPMEHELSAYYDITHGVGLAILTPNWMEYILNDDTLHKFVSYGINVWGIDKNKDNYEIAREAIKNTREYFNSLGIPSKLREVGIGKDKLELMAKQAVRNSGGTIGSLRPINAEDVLEIFKKSY
Protein: Histone deacetylase complex subunit SAP18 (Q90ZH5)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFNFAIVFTDLKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPNRAPPPSSRMRPY
Protein: Nuclear pore complex-interacting protein family member A1 (Nuclear pore complex-interacting protein) (NPIP) (Q9UND3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:11586358}. Nucleus membrane {ECO:0000269|PubMed:11586358}. Note=Colocalizes with nuclear pore complex protein NUP62.
Interaction partners:
- Nuclear pore glycoprotein p62
Sequence:
MFCCLGYEWLSGGCKTWHSAWVINTLADHRHRGTDFGGSPWLLIITVFLRSYKFAISLCTSYLCVSFLKTIFPSQNGHDGSTDVQQRARRSNRRRQEGIKIVLEDIFTLWRQVETKVRAKIRKMKVTTKVNRHDKINGKRKTAKEHLRKLSMKEREHGEKERQVSEAEENGKLDMKEIHTYMEMFQRAQALRRRAEDYYRCKITPSARKPLCNRVRMAAVEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSIIDNSLSLKTPSECLLTPLPPSALPSADDNLKTPAECLLYPLPPSADDNLKTPPECLLTPLPPSAPPSVDDNLKTPPECVCSLPFHPQRMIISRN
Protein: Small ribosomal subunit protein RACK1z (Guanine nucleotide-binding protein subunit beta-like protein A) (Receptor for activated C kinase 1A) (WD-40 repeat auxin-dependent protein ARCA) (O24456)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Major component of the RACK1 regulatory proteins that play a role in multiple signal transduction pathways. Involved in multiple hormone responses and developmental processes. MAPK cascade scaffolding protein involved in the protease IV and ArgC signaling pathway but not the flg22 pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22068106}. Nucleus {ECO:0000269|PubMed:22068106}. Note=Detected in the cytoplasm and nucleus when interacting with NUDT7.
Interaction partners:
- Large ribosomal subunit protein uL4z
- Small ribosomal subunit protein eS12z
- Small ribosomal subunit protein eS1z
- Large ribosomal subunit protein uL4y
- Small ribosomal subunit protein uS2z
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS12y
- Large ribosomal subunit protein eL8z
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL16z
Sequence:
MAEGLVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALCFSPNRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVWGIGRY
Protein: Nucleosome assembly protein (C8V9B5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Histone H2A.Z
- Histone H2A
- Histone H2B
- Importin N-terminal domain-containing protein
- 40S ribosomal protein S6
- Protein SDA1
- Large ribosomal subunit protein eL39
Sequence:
MSEPIRNKKADFPVAPTPQNTPANNAPISSHAQQPGVSSIKEESLDHATAASLFARNPGLVSMIQGKLGSLVGRSSGYIESLPVSVRRRVAGLKGIQKEHAKLEAQFQEEVLELEKKYFAKFTPLYERRATIVNGATEPTETEIEAGKGEEEEIDAKDEDLKQGEDEKESAVTGIPEFWLSAMKNQISLAEMITDKDEEALKHLIDIRMEYLDRPGFRLIFEFSENEFFTNKTISKTYFYKEENGYGGDFIYDHAEGTKIDWKPEKDLTVRVESKKQRNKNTKQTRVVKITVPTESFFNFFAPPQPPADDDDTVATDIEERLELDYQLGEDIKEKLIPRAIDWFTGEALQFEELGDDMDPDEFDEFDDEDDEDDDEDEDGRGSDQDVDDSDEEDGTSKPKKEAAECKQS
Protein: Envelope stress response regulator transcription factor CpxR (Two-component response regulatory protein) (A0A0H3NK16)
Organism: Salmonella typhimurium (strain SL1344)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MNKILLVDDDRELTSLLKELLEMEGFNVLVAHDGEQALELLDDSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQSSDNGSPTLEVDALSLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPERKDGHPWFKTLRGRGYLMVSAS
Protein: Amino acid transporter, putative (Q584L8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEVRNEPIGCCDAAVDPKSQEQREGTGFLARMSTFVATAIPPGGIAASAFNIASSTVGAGIVGLPSAANSSGLVMAIVYLIIITVMTIFSIYALGVAADKTKTHDFEGVAKVLFGAKGSYLVAATRAFHGFSACVAYIISVGDILSAILKGTDAPDFLKEKWGNRLLTFIMWLCFMLPLAIPREVNSLRYVSTFAVSFIVYLVIVIVVHSCMNGLPENIKNVSVGRNDVAAIVLFNSGNKAIEGLGVFIFAYVSQITAYEVYMDMEDRSVRKFIVATSIAMATCSVLYAMTAFFGYLDFGRDVTGSVLLMYDPVKEPAIMVGFIGLLVKLFASYALLGMACRNALYSIIGWDAEKVIFWKHCVAVVTLSVIMLLCGLFIPNINTVLGLAGSISGGLLGFIFPALLLLYAGGFTWQKVGPFHYIATYTLLLSGVLAIVFGTGATIHGVVVGN
Protein: Endoplasmin, putative (B9R8A7)
Organism: Ricinus communis (Castor bean)
Interaction partners:
- Protein SGT1 homolog
- Chaperone binding protein, putative
- Calreticulin
- Calreticulin
- Heat shock 70 kDa protein, putative
- Calnexin homolog
- Rar1, putative
- Heat shock protein, putative
- Heat shock protein, putative
- Heat shock protein, putative
Sequence:
MRKWTIPSALLLLCLLSLISDQGRNLHANAEADSQNPVDPPKVEEKLGAVPNGLSTDSDVVKRESESISKRSLRSDAEKFQFQAEVSRLMDIIINSLYSNKDIFLRELISNASDALDKIRFLALTDKEVLGEGENTKLDIQIKLDKEKKILSIRDKGIGMTKEDLIKNLGTIAKSGTSAFVEKMQTSGDLNLIGQFGVGFYSVYLVADYVEVISKHNDDKQHVWESKADGAFAISEDTWNEPLGRGTEIRLHLRDEAGEYLEESKLKELVKKYSEFINFPIYLWASKEIDVEVPADEDESSDEEEKAESSSSDEEEETEKGEDEDTEEKPKTKKVKETINEWELLNDVKAIWLRNPKDVTDEEYTKFYHSLAKDFGDEKPLAWSHFTAEGDVEFKAVLFVPPKAPHDLYESYYNANKSNLKLYVRRVFISDEFDELLPKYLNFLKGLVDSDTLPLNVSREMLQQHSSLKTIKKKLIRKALDMIRKIADEDPDEMKEDKKDVEDSGDDEKKGQYAKFWNEFGKSIKLGIIEDATNRNRLAKLLRFESTKSDGKLTSLDQYISRMKSGQKDIFYITGPNKEQLEKSPFLERLKKKGYEVIFFTDPVDEYLMQYLMDYESKKFQNVSKEGLKLGKDSKDKELKESFKELTKWWKGALASENVDDVKISNRLDNTPCVVVTSKYGWSANMERIMSSQTLSDASKQAYMRGKRVLEINPRHPIIKELRERVVKDPEDDSVKETAQLIYQTALMESGFMLNDPKDFASRIYNSVKSSLDISPEATVEEEDDVEETEAETETENKGDTEASKPDADTDAKDEL
Protein: Low affinity ammonium transporter (Ammonium facilitator 1) (Q08902)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Low affinity ammonium transporter of the plasma membrane. May be involved in drug resistance through pumping them out of the cell (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:24707045}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Uncharacterized protein YOL097W-A
- Putative uncharacterized protein YOR392W
- Uncharacterized membrane protein YOR365C
- Vacuolar basic amino acid transporter 2
- Vacuolar basic amino acid transporter 4
Sequence:
MSTSSSVTQKNLDTNAEALKKEDKVLSEFDIQDERPKSLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGNSFGTTNAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMPSRDASSFKLLERIDFAGSVTGVVGLILFNFAWNQGPVVGWQTPYTYALLIVGTFFLVIFAYIESRAAFPLLPFAALSSDTAFVLSCIAAGWASFGIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTILIATAPVHQTYWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIGLGIAGTIESRVNDGGAKPLKGYRCSWYMGIGLSGLGIFVAATYAWSTFMKSKKRISEKQHFIE
Protein: Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) (Q62838)
Organism: Rattus norvegicus (Rat)
Function: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.
Subcellular location: Postsynaptic cell membrane {ECO:0000305|PubMed:17011580}; Single-pass type I membrane protein {ECO:0000305|PubMed:17011580}. Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction. {ECO:0000250|UniProtKB:O15146, ECO:0000305}.
Interaction partners:
- Agrin
- Docking protein 7
- Low-density lipoprotein receptor-related protein 4
- 43 kDa receptor-associated protein of the synapse
- Neuronal acetylcholine receptor subunit alpha-2
- Acetylcholinesterase collagenic tail peptide
- Segment polarity protein dishevelled homolog DVL-1
- Acetylcholinesterase
- Acetylcholine receptor subunit delta
- Protein Wnt
Sequence:
MRELVNIPLLQMLTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSALRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEVEVFARILRAPESHNVTFGSFVTLRCTAIGMPVPTISWIENGNAVSSGSIQENVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKESKGYCAQYRGEVCDAVLVKDSLVFFNTSYPDPEEAQELLIHTAWNELKAVSPLCRPAAEALLCNHLFQECSPGVLPTPMPICREYCLAVKELFCAKEWLAMEGKTHRGLYRSGMHFLPVPECSKLPSMHQDPTACTRLPYLDYKKENITTFPSITSSKPSVDIPNLPASTSSFAVSPAYSMTVIISIMSCFAVFALLTITTLYCCRRRREWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCERAEGTVGV
Protein: Protein HEADING DATE 3A (FT-like protein A) (Q93WI9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable mobile flower-promoting signal (florigen) that moves from the leaf to the shoot apical meristem (SAM) and induces flowering. Promotes the transition from vegetative growth to flowering downstream of HD1 and EHD1 under short day (SD) conditions. Acts upstream of MADS14 and MADS15.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Interaction partners:
- 14-3-3-like protein GF14-C
- Os07g0295200 protein
- Protein RICE FLOWERING LOCUS T 1
- Os01g0218500 protein
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS2c
- Os02g0102400 protein
- Large ribosomal subunit protein mL46
- Os08g0513300 protein
- Large ribosomal subunit protein bL27c
Sequence:
MAGSGRDRDPLVVGRVVGDVLDAFVRSTNLKVTYGSKTVSNGCELKPSMVTHQPRVEVGGNDMRTFYTLVMVDPDAPSPSDPNLREYLHWLVTDIPGTTAASFGQEVMCYESPRPTMGIHRLVFVLFQQLGRQTVYAPGWRQNFNTKDFAELYNLGSPVAAVYFNCQREAGSGGRRVYP
Protein: Ras-related protein Rab-9A (EC 3.6.5.2) (P51151)
Organism: Homo sapiens (Human)
Function: Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}. Golgi apparatus membrane {ECO:0000305|PubMed:34793709}. Late endosome {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:34793709}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:34793709}. Melanosome {ECO:0000250|UniProtKB:Q9R0M6}. Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). Mainly localizes to late endosomes and partially localizes to Golgi (PubMed:34793709). Colocalizes with NDE1 to membrane vesicles (PubMed:34793709). {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:34793709}.
Interaction partners:
- GRIP and coiled-coil domain-containing protein 2
- Pleckstrin homology domain-containing family M member 2
- Rab GDP dissociation inhibitor alpha
- Rab GDP dissociation inhibitor beta
- Nuclear distribution protein nudE homolog 1
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Ras-related protein Rab-9B
- HLA class I histocompatibility antigen, A alpha chain
- Vacuolar protein sorting-associated protein 18 homolog
Sequence:
MAGKSSLFKVILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWKKEFIYYADVKEPESFPFVILGNKIDISERQVSTEEAQAWCRDNGDYPYFETSAKDATNVAAAFEEAVRRVLATEDRSDHLIQTDTVNLHRKPKPSSSCC
Protein: Eukaryotic translation initiation factor 4E type 6 (Q57V43)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Probable eukaryotic initiation factor 4A
- MIF4G domain-containing protein
Sequence:
MAAEATEKPHPLKDRWFVSYFPVVKQKKFSKDSEEQKGVELDWVSTAEELHATINAFSPLTLLPPDDNLVFAREKVEPFFENFPNGMRVSVFTRTKVQATQAVPLVLAAVMGEHLRTVTDGPSHADVVRIAHKPGTVYPESLRVEVWLRDRSKVDAVTKYFSEMLAPHPGIRVAGRPINAEGEEAK