wanglab/gogpt-training-data huggingface dataset:
Protein: Ras-related protein Ral-A (EC 3.6.5.2) (P63320)
Organism: Saguinus oedipus (Cotton-top tamarin)
Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody. During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P11233}; Lipid-anchor {ECO:0000250|UniProtKB:P11233}; Cytoplasmic side {ECO:0000250|UniProtKB:P11233}. Cleavage furrow {ECO:0000250|UniProtKB:P11233}. Midbody, Midbody ring {ECO:0000250|UniProtKB:P11233}. Mitochondrion {ECO:0000250|UniProtKB:P11233}. Note=Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles. May colocalize with CNTRL/centriolin at the midbody ring. However, localization at the midbody at late cytokinesis was not confirmed. Relocalizes to the mitochondrion during mitosis where it regulates mitochondrial fission. {ECO:0000250|UniProtKB:P11233}.
Interaction partners:
Sequence:
MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRADQWNVNYVETSAKTRANVDKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERCCIL
Protein: Uncharacterized protein (Q382V2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIELLLEVALSIIICVVAAYFFFLSSPVEEYGVGEGSRSYEHGSNISNSRGGYSKSSDNRHLSPYSRRNASSLERSKKCEPAMWCNVVGRLVSLLVLGGGSVDGNVWVDRIAYFIGKGVKSVDEAFDEGRKTRGAHGITTQTLRVKADMLRLLRMELSSGGTLSTAGGAHHQQQQSHSTSPQVGGMFHTRTSSEHARGVGIFGEPPEGGAAGGTVATGVGCNNGPAPANSPLVGVVLPRVGPGGITSVEVPLSAVTQELGFDDCGTHVAESGRPSMLRCFAVPITYEDHRFLLHVVCNLPLLAALPQSLSIPSDVLTLRCGLSVKRVVFHGVLYAAFCGNSIELSFSSEPQFTALFDVAPPRRQDHHDRYYQQQNQPHSHLLPTECNSARGPAASVSNASSLPLPPSTLAAHNSSQRYGSNVNQGVSNEGHRTREKLQEIVDAAVRRAIQSITYPCVLRGHLNKGTMSKAQSVGGGETEQLFGVPNTGLLTWTLERASLPLCC
Protein: Acyl-coenzyme A synthetase ACSM4, mitochondrial (EC 6.2.1.2) (Olfactory specific medium-chain acyl CoA synthetase) (O-MACS) (Q7TN78)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12709059}.
Interaction partners:
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
- medium-chain acyl-CoA ligase
- Acyl-coenzyme A synthetase ACSM3, mitochondrial
- Citrate synthase, mitochondrial
- Hydroxysteroid dehydrogenase-like protein 2
Sequence:
MKVLLRCQRLRFIWLAKPAGRHFHRDPQLWAPLTLDDFEAINRCEKPLPKNFNFAADVLDQWSLKEKSGERPANPALWWVNGKGDEVKWSFQELGSLSRKAANVLTKPCGLQRGDRVAVILPRIPEWWLINVACMRTGLVFMPGTIQLTRKDILYRLQASKAKCIVASEEVAPAVDSIASECPNLKTKLLVSPHRWDGWLSFQELLQSASEEHNCVQTGSQEPMAIYFTSGTTGSPKMAQHSQSSLGIGYALCGRYWLDLTSSDIMWNMSDTGWIKAAIGSVFSTWLRGACVFVHRMAQFNTDTFLDTLTSYPITTLCSAPTVYRMLVQQDLKRYQFKRLRHCLTGGEPLNPEVLEQWKAQTGLELYEGYGQTEVGIICANRKGEEIKPGSMGKGVVPYDVQIIDEHGNILPSGKEGEIALRLGSDRPFCFFSEYVDNPEKTDATIRRNFYITGDRGVMDDDGYLWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFIVLAAPFKSSNREKLTAELQDHVKNSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWGRA
Protein: BICD cargo adaptor 1 (D4ADZ2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Ras-related protein Rab-6A
- Dynactin subunit 2
- Dynactin subunit 1
- Cytoplasmic dynein 1 heavy chain 1
- Cytoplasmic dynein 1 light intermediate chain 1
- Cytoplasmic dynein 1 light intermediate chain 2
- Ras-related protein Rab-6B
- BICD cargo adaptor 2)
- Cytoplasmic dynein 1 intermediate chain 1
- piRNA biogenesis protein EXD1
Sequence:
MAAEEALKTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDGLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLNKILEMQNELKQSRAVVTNVQAENERLSAVVQELKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLSDNHISISVEGLKFAEDGSEPNNDDKMNGHLHGPLGKLNGDYRAPTARKGESLHPVSDLFSELNISEIQKLKQQLIQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQNSKELKAELDCEKGRNSAEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTEEKTKYESKIQMYDEQVTNLEKTSKESGEKMAHMEKELQKMTGIANENHNTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLSRRGVSSPVESRTSSEPVSKENTETSKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKFLVDCQQPAASVPPQCSQLAGRQDYPTVSPDIALSKEQPHSSSQCAPLHCLAKPPYP
Protein: Protein myomixer (Microprotein inducer of fusion) (Protein minion) (hMINION) (A0A1B0GTQ4)
Organism: Homo sapiens (Human)
Function: Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK (By similarity). Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation. Acts independently of MYMK (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q2Q5T5}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q2Q5T5}.
Interaction partners:
- Protein myomaker
Sequence:
MPTPLLPLLLRLLLSCLLLPAARLARQYLLPLLRRLARRLGSQDMREALLGCLLFILSQRHSPDAGEASRVDRLERRERLGPQK
Protein: Translation elongation factor eEF-1B gamma subunit, putative (Q4WR90)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- Elongation factor 1-alpha
- Elongation factor 1-beta
- Translation elongation factor eEF-3, putative
- ABC-type ATPase Hef3-like, putative
- mRNA-nucleus export ATPase
- Small ribosomal subunit protein uS5
- 60S ribosomal protein L6
- Small ribosomal subunit protein uS2
- 60S acidic ribosomal protein P0
- 60S ribosomal protein L19
Sequence:
MSFGTIYSYPNNPRVMKILAAANLNNLSISTPAFSFGTDNRTPEFLAKFPFGKVPAFEGTDGTKLVESDAIAQYVAESGPAAAQLLGTKPVERAAIRQWIAFADGEIQSPVIPLVLPRIGLAAFDEAVEKKNLEKLERSLAYLEGHLSGRNWIATEEKLSLADITVVSALYWAFSTVIDREMRQKYPVVVSWYEKTIESEGVKQAFGEKKFIEKREIPKA
Protein: Exopolyphosphatase-related proteins (Q8NP42)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Interaction partners:
- Ribosome-binding factor A
- 3'
- sulfate adenylyltransferase
- Sulfate adenylyltransferase subunit 2
- Adenosine 5'-phosphosulfate reductase
- Na+-driven multidrug efflux pump
- Translation initiation factor IF-2
- Phosphopantetheinyl transferase component of siderophore synthetase
Sequence:
MTDNSQFHAASALVQAAHTVSVVGHLRPDADAIGSVAATVAALQQLGKDAVGAIGQLDSMPENLYTIPGASNIKFGDSLPESDLIIVVDCGSIERTGAFESIIVNNPDKVLVVDHHATNPGFGAVNLIDVEAESTTTILYDWFDAMSVQITPDIAHGLYAGLLTDTGCFRWGRPVMHDMAKELMEFGLDIRAISSALLDQTSVDDLRLVGQIVSRIELREAGPYTLAVLVADFDTINGRSRAVVEGLIEMVRAVEGADFGAVFKEYERGVYTVSLRSSNLSVASLAVHLGGGGHIPAAGYTARGTEIEALDTLIEATVTLGESLRSSAHVDV
Protein: Small VCP/p97-interacting protein (Q8NHG7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000269|PubMed:17872946}; Lipid-anchor {ECO:0000269|PubMed:17872946}. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P0C0A9}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C0A9}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P0C0A9}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C0A9}. Cell membrane {ECO:0000250|UniProtKB:P0C0A9}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C0A9}. Lysosome membrane {ECO:0000269|PubMed:35042898}.
Interaction partners:
- Transitional endoplasmic reticulum ATPase
- Nuclear protein localization protein 4 homolog
- UBX domain-containing protein 6
- UBX domain-containing protein 2A
- UBX domain-containing protein 1
- UBX domain-containing protein 4
- NSFL1 cofactor p47
- UBX domain-containing protein 8
- E3 ubiquitin-protein ligase AMFR
- Protein SEC13 homolog
Sequence:
MGLCFPCPGESAPPTPDLEEKRAKLAEAAERRQKEAASRGILDVQSVQEKRKKKEKIEKQIATSGPPPEGGLRWTVS
Protein: Calmodulin-binding transcription activator, isoform E (B7YZS4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAGYRSLPLAPVAATAAVQPTMGGVPPTMAAYAHHQSMTAMSNNGIIYQSAVHASIHSLNTVQSQHRSSTTTHHHILATATATATATAAAAAATATAAAAAAAAVVALPTAAATAAAPQQHAAYGQQQPQQHLQSQHQQQQHLGQHHTQQHSQQHAQQQQQLMTHQQHSVAQQQHHHLQQQQHLQQQQQQHHHHHHHHHHQQLSLHQNHLYFSGASLGHHHHHRQIFSHLQSALMPLSVNGEPIKLPDNLESLPRADSFPSQRHRWNTNEEIAAILISFDKHGEWQSKEVRTRPKSGSLLLYSRKKVRYRRDGYCWKKRKDGKTTREDHMKLKVQGTECIYGCYVHSAILPTFHRRCYWLLQNPDIVLVHYLNVPYPDDNKMAVIAPSITLWGDKKEWTKEELVSQLKPMLSTINSDDDSDSGNDIEISTAETVESIVCQLMEKQRLSRQAALVKQLDCGCGDGGCVDGKTCTHPVMRRSAAMLKSSVQEKRLGEPFNGNTPNVVVASKLYSRWAERPRQHVDNHGQFHNVTQQLPQESAIKFQIIPPQQQQQQDGNYQQQQYRGGSQMLAARSNLVMQQQQQHQQQQQYHQQQQQQQQQQQQHQQQQQHLSLQRFVASQGQNSVHLNQQHRLQIANTTITATASDPATTLAAAAAVAAASGATPVALNIMDTELIENQNHMTANKITNSGSSNSSSSNASKQLAGQTNNKLNVVNNNDPGNNNFMYNQQQQLNASSNSNNSSQQQQQQQQQHYYKLQQTTATPTSGQPPPLAQVQPHSLAQPPVEAMCMSPEHRSSSQPTPATSSAGSIPSSVSVSISVSTSTPTPAPTSISTPTSGTSSTSSSLQSIIDGNQQQQITTTSTAATCDNLMSANALSEQDSHTVNNQATEAPNRSQLQSQSQSLSLNQNGCATYSASSDNSSQISDESSSFGGNNQNSSNSSTSEEEPQVEALSFFNETLDLSQEDIQRTLIANMPYNTTAAGATAPSTTITTGNTKLELSQQETKEKPAMGTETATEIEDDETDDVFANLDAFDMLVEFPELDLDDKQALNNTALEQSSFLGESAPSQPRKVHNICDFSPEWSYTEGGVKVLVAGPWTSSNGGAYTVLFDAQPVPTQLVQEGVLRCYCPAHEAGFVTLQVACGGFLVSNSVMFEYKLSLLADAPFDATSSNDCLYKFTLLNRLSTIDEKLQVKTEHELTTDNTALYLEPNFEEKLVAYCHKLIKHAWSMPSTAASWTVGLRGMTLLHLAAALGYAKLVGAMLNWRSENPHIILETELDALSQDVYGFTPLAWACVRGHVECSLLLYKWNHNALKIKTQAQQTPLDLASMRGHKVLLAQMYRLEKERCRKPQLRGGLANLSMNMGVEAEAEEQHQSFSAFDLELQRKHDGVFLRPVAVHSNQSPPNGSSRYSKRSSIDSGINMDIRSKSGKPLARLHSNFESHDSYALGVDSPLDSLTGTNCLLSPLRKMDFALWDSDAKVLTLAEHIIAAMPERIKNEADEMMVLGSPLTEPLTSESSALTDSFMDPLLDSLPNTHFDSDFSFDFHDHSYRYHDVSTPCSSLSPASSGPLQSPASYSILGTDPSVSSPSPPPSTKQLTEFLHASSISSYPFEADFSKLTLTDTEQRELYEAAKCIQKAYRSYKGRQKLEEQNKERSAATVIQNYYRRYKQYAYYRQMTNAALVIQHGYRSYRRNKRFKKSGLCLSSSSDHGSVSSNSQCLSSFYDHYKQDQQQLHELGSQPSTPKETSPSGPLKRTYSQSTQNQAARKIQQFMRQSRIKLQKERAEKEKLVHQRRAEYLQNLQFQGQQEMLVYHENNISAPSSGNTNASNNNNLHQIQSNQ
Protein: Cyclin-dependent kinase 5 activator 2 (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (p39) (p39I) (O35926)
Organism: Mus musculus (Mouse)
Function: Activator of CDK5/TPKII.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Cyclin-dependent kinase 5
Sequence:
MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPAGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDGPDGGGTAKPLAVPVPTVPTTAATCEPPSGGSAAAPPPGSGGGKPPPPPPPAPQAAPPAPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASTGGPPSGSSASTTSSSSARDSCATGAKHWTMNLDR
Protein: Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (Q8IYJ3)
Organism: Homo sapiens (Human)
Function: May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}; Peripheral membrane protein {ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}; Cytoplasmic side {ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.
Interaction partners:
- Ras-related protein Rab-27A
- Ras-related protein Rab-27B
- TBC1 domain family member 10A
- Rab effector MyRIP
- Unconventional myosin-Va
- Neutrophil cytosol factor 2
Sequence:
MPQRGHPSQEGLWALPSLPMAHGPKPETEGLLDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLRASVADPGQLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRKKSTRGDQAPGHDREAEAAVKEKEEGPEPRLTIDEAPQERLRETEGPDFPSPSVPLKASDPEEASQAQEDPGQGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSSSSSVSSLNSSTLSGSQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPDKQSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEPTWLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPPSGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLRTNLAPRT
Protein: RNA helicase (EC 3.6.4.13) (A0A0E3D804)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDPNMSSDQDTETRHILDCFRDRLKRLIQVEPLLDLLDFLEPDKKERIKAKVASEGNINAVSLLINEIMRAELQQGWSRTLVTALETVGCGHAARYVRNRPPEPDEEAEHDSCVRLIDLLHLSLVNMKTRDVCVQCVTLGLLTQEDQENIMTATGNNGNINGARLLLKRLVKNEAGWFSKFLQALEDTEHRDLMRELRGEPCEGDEGMSVDSSDAQAEVKDTGAVRRNSMSSPPPSFTPNSSLQSEDLDDSVDSSVLGVEAGNRGVEMYEDGEEKEEKDLKEDEDDDSSASKREIKLRDYQMEVARPALEEKNIIVCLPTGSGKTRVAVFITKEHLEREQRMGQKGKVVVLVNKVPLVEQHYKAEFGRFLKHQYSVERVSGASQLKISFPQIIEKNDIIICTAQILENSLAKAKNGDEDGIELSQFTLMVIDECHHTKKGGVYNHIMIRYLEQKNRNQLLKKQDKTLVPIPQILGLTASPGVGGAVSQQMAEEHILQICANLDAFTIKTKTFEEEEAKTPFKRIAKAEERKEDPFGDVIKKIMDEIHTHADLQPLCEPGTQNYEQWVVQKGQNAAKEENQNVRVCAEHLRQYNEALHQSNTIRMSDAFRFLDKYHNEELKTKSSPDEEGNITITDTERFLFTLFKDKKAKLQELMGKPQYENNNLAQLKTIILKEFCTREKARGIIFTQTRLSAIALCQWIEENPKFDEVGVQASYLIGGGDQSVVKPMTAAEQKDVLKRFRTGEINLLIATTVAEEGLDIAECNVVIRYCLVTNEVAMIQARGRGRAEDSSYTLVAEAGSGVAERESVNEYREKMMSKAIAKVCKMNRADYEKKIMEFQIQAIMEEKVKTKKKQQKGMMKEAPSKIRLSCRQCSVFVCSGEDIEIIEKMHHVNVTKQFRKLFIVRENASLQERLLDYETNGVIACKKCGQQWGSMMLYRSTECPCLHIKNFVVTYGSKKKTFSKWRELSISFPAFDYTQHADLLVEDSEDEDMDTN
Protein: chitin deacetylase (EC 3.5.1.41) (B9WKM5)
Organism: Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Interaction partners:
Sequence:
MISWLGFYIMILIPSIINGSDLSLRLQSKFMPTSFSPRNIFDTHNNPTINTINNNKEDQSGSGGGSGGRGGGLPPSPMQFPPKLPFPKWLSDFTGLHEWPDLDPPYIPLDFIDFNKIVNIPIHKQGQCHDTNIKTKTNTNNNNNNNQSPLSILRTPKACSFDCFNCVEIDDVYTCPKLSQTFDDGPSMATLKLLQSFNQTGLKTTLFTLGVNIVRFPEIYQQCHLLGHIMGSHTWSHKFLPSLTNQEIISQIEWSIWAMNATSNHLPKWFRPPYGGIDNRIRSILRQFGMQAVLWDFDTFDWKMLGGDSSGGTTSSNNNRRKEEDVFSEVEKFKLMKNNKGLILHHDAIQKTVDVGIMIHEKLLNHDQLTVPLCVGGIDYIKTFPK
Protein: Palmitoyltransferase ZDHHC21 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 21) (DHHC-21) (Zinc finger DHHC domain-containing protein 21) (Q8IVQ6)
Organism: Homo sapiens (Human)
Function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor. Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:22031296}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q9D270}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:16647879}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Nitric oxide synthase 3
- Estrogen receptor
Sequence:
MGLRIHFVVDPHGWCCMGLIVFVWLYNIVLIPKIVLFPHYEEGHIPGILIIIFYGISIFCLVALVRASITDPGRLPENPKIPHGEREFWELCNKCNLMRPKRSHHCSRCGHCVRRMDHHCPWINNCVGEDNHWLFLQLCFYTELLTCYALMFSFCHYYYFLPLKKRNLDLFVFRHELAIMRLAAFMGITMLVGITGLFYTQLIGIITDTTSIEKMSNCCEDISRPRKPWQQTFSEVFGTRWKILWFIPFRQRQPLRVPYHFANHV
Protein: Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT (EC 6.3.5.13) (A0A0H3JUU7)
Organism: Staphylococcus aureus (strain N315)
Function: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.
Interaction partners:
Sequence:
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDVLRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNADDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISSFDVAPFLYLNINDEKYDMKIAGDFNAYNALAAYTVLRELGLNEQTIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
Protein: Vomeronasal type-1 receptor 40 (Vomeronasal type-1 receptor A11) (Vomeronasal type-1 receptor B7) (Q9EQ46)
Organism: Mus musculus (Mouse)
Function: Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MNKANMLRTDKDMQIILFSEVSVGISANSILFIAHVCMILGENRPKPIDLYIAFLSLTQLMLLITMGLIAVDMFLSQGIWDSTTCQSLIYLHRLLRGLSLCATCLLNILWTITLSSRSFCSTKFKHKSPHHISGAFIFFCVLYMSFSSHLFISIIATHNLTSENFIYVTQSCSLLPLSYSRTSMFSAPMAIREAFLVSLMALSSGYMVALLWRHKKQAQHLHSTSLSSKASPEQRATRTILLLMSFFVVLYILENAVFYSRIKFKDGSILYCVQIILCHSYATVNPFVFICTEKHIIKFWESKCGRIVNI
Protein: CSA-conditional, T cell activation-dependent protein (Q9D245)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MRWGLPPLLQTCLEFGAQLSHNGGSQGRDPVKHRGCTLRSWGVARYLPGEFCTGRLSQLLRQSCACLHGFQEHLLGDLAHHIVSLRAIMSWYSQWPAFQVQGQP
Protein: Gamma-glutamyl carboxylase, isoform A (EC 4.1.1.90) (Gamma-glutamyl carboxylase, isoform B) (RE52814p) (Vitamin K-dependent gamma-glutamyl carboxylase) (Q9W0C4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- vitamin-K-epoxide reductase
Sequence:
MANSKRKLPTKPSATEDATPHKDTPRSSEEFPTDVNHKSAKKSFLPQNAFFRDCLGHDLSNFTSLTNFTSWLNRPVDGAALGIFRLLYGAAMLIDIAEERGGGQLDVRFQEPLHCHFPLFNGMRALDYPLMGCVYLCMWLGAWGIMLGYRFRTSCLAFLIPYWYIFLLDKPTWNNHSYLFGLVGTLLLFTQAESYCSLDRWLNPRKSHCIPYWNYFLIKFQFFILYMYAGLKKFSLEWLSGYAMSNLSYHWVFAPFRQVIDPELIDLLIVHWFTAFFDVSIAFFMTLEKTRLLVTPFMLSFHLMNSRLFVIGMFPWVCLAEVPLFFSFDWPRRLGNWSKIQDVHPKDPEEELSKPGILARLRTGLILAYCGLQLFLPYSHFITKGYNNWTNGLYGYSWDMMVHSYDTLQTSIQVVDNESRQVHNLNPYAFTEYDRWTKYADMAVQYARCIEENLQEKQPHIGRNISIYFDIWCSMNGRFQQRSFDPREDLLRAKWSPFESTSWSLPLLNELNHMRPKLRTIETEVLAWNNYSDVIFVADFPGLTLTNFISPDLINCTLTILEGNVRYRNERDPEAYFLTAGKSIGLESNITHLVTTIGQKPASYLFTYTNKTMLEQGITIEQPDTEERSVLPLWQEFQHRVTNYQQFLGHIGNCLMYLLYDVPIPQAVKGGD
Protein: Uncharacterized protein (Q585M0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTKEEVLSSAQRIQLLRERLEMYNATIVEAMGVVAGTANNEEGTSFNGGESASPPSSSRIRVGHNGVNSSLHTIRKSKTDHPYHVERGNAADFESSRVVGGDSRRGDRRAAPPPPPSPPKDGHQRDLASRSVTMTSEITGEDHDSTLSFSESEDYYEEACASEQAFSEGMEGSAGDTLQNDGRQSPTLAHTLSRGENAAELAASHSGSWTTYYVKSYEGEDSQDEEIRSYSRSQKGSVVIRGDSQELLEAVSAQAPLPTPPPGAAVFTTLESTLYKMLFFEQSLRKLLSTIDFDHFPRSLPQEQKGRQLAEARDQLIEKERALRNKKSGEPSISDLRDNDATVIVDQIQHLLLECENTKGLFQRVYERKASVSGKERLLQQRLSELESRQREVGERRKVLTALESRLEEQESALLKREGKYRSELEAHKERDSMLQGRIGEVESLTRKVSSWMKILEERDAEMAAKEQRLRRVQTDLLRRSEGLLCYRNGKAKESARIPPRLEKTP
Protein: Transcriptional coactivator ADA2 (Q8IJP9)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- PI3K/PI4K catalytic domain-containing protein
- CCR4-NOT transcription complex subunit 4, putative
- SANT domain-containing protein
- WD repeat-containing protein, putative
- WD repeat-containing protein, putative
- histone acetyltransferase
- CCR4-NOT transcription complex subunit 5, putative
- Uncharacterized protein
- Bromodomain protein, putative
- Erythrocyte membrane protein 1, PfEMP1
Sequence:
MNINKYEEFYPSILMHERQCGLSSAYIVYEKEQLEILEQEVLKAIIIKALIIEEVIKYIKCILYKIELIKYNNNNNNNNNNNNDNIILTSYDNTNIRKNQIKNVYCPKLLNKNNNIIYDNNLIKDIDRNNFKNKLYIIQFNGNESVRRNFFKTEQKNTISNDNIRIQGNDVIENKNEKINKSLCNIISNENKEIVLNKKNLDTLMLLEKIKTKTISFINKSSYVVIYKSINDYNNVLQKELIDISSKCCNNKFQLYSKNINSYSIIDYVTGHINKMKEYQMRNKFLDDIIVKIKDELYINIDLIYKNKNNKSFLSVMENINYTIVNTYNINQDKLESFKYLHFNFFYICSKLENKSISNINKYNKVNNNICNIFLYFFVMIFFHLYIQNSDDKRKEDICNNFYNILKYNSYNYEKFYVFILLCIKCIVSIRNDKLINFVPHNGRKKFSNDDNKELYNDNSTEKKMTIRTGYHFKFNINKKSIHNRNYYFINYAHHVIFNTLYYCIVKGCNIYYKIKKSKEFKRNTYYNNNNYQWTNYFNYIQLYNKCKKINNKYRKMKIIGEIILSKNLKYENNKKNKTGSDRLSGTYFLYNNNKKRNYFIVYYKRYIKRGYANSGNNKQKMFCFKNDNIVLLNKIILYLIDKNRKDAIKKDKLNIKEWHRNTKLYCNSNNAEGGDGGYNNHSNSNYRNNGNNNIGNYNNNGSNFFGNNMGGNNNDNDDNDNNDENNYKPKNTCNDDDNDNDNDGGNKNNSGKYNNSVNKNDNNNNNNSTDGVYGNNVDNVNNVMMNHYGDKIPISNENGYDNNSNVIHKKMVDNKLEGINKSASNNNMINNKVMNSAGMMSSNGDMNYNLNYMNYMNNTNNINMPGSGGGSGVNRMTTVPINHVMNFPNSYMSGANMPSQVPQNMHFDAIENMHDMKQTPQQMKHKTSQLNSSANQGDINNNAKQVGGLPANFMQNQMHPQYQYQQQVHMQQLVQQQNVHGYNNMMQSNNQQKFPNQPGAHKQSNASILKMPPFSSLNSGDQRSSYSIAQKLPRHVMDTNNNVPSINNNNSSSNNNNNPRHSSSNMPSLNNPNQFNSVSLKFPYKGSSPQPLNSINNNNNPNQPNQQNHQNQPNHMPNISAQQNMQNVNNNNNNPSVVQQMNVNHPIMQHNMIQQNQNNMHNLAPNKPNESQSMFPLGASSNQQGNMQNIASPNKQKMQPLFQQGGQQIIAPNQKGINTASISGSISRQPNQGTGQIPISHQNIQQFYHNNSGQMFPQQPPFLQRVSTTPQHVPQQQVPYEWMNNPYMHHQYMLQQCQLTPQQLFMHQQKQQNNMLHHQQQQQQQLQHQQMQQQQLHQQQIQQQQLHQQQIQQQQLHQQQIQQQQIQQQQLQQQQLQQQQIQQHQLQQQQQQQQQGNIPPLSARQSKQGILQMQSQNNISHLPPNLEQHFQQQNISELQHHQQQMQNVSAQHSSISTFEPNAQQTMYQGEMFKDSNILQGGHNLEIVDGVNEMQRTNDAFKGGNIIEASNVSLEAITEEDIFDSNYHCDICNKDITHTIRIRCAECVDFDLCVNCFSTGKEMKSDKCEHYNYHNYIPIPKYDFPLYKLNWSAEEELLLLDGISKFGFGNWEQVADLVNSVANITKTDRECESHYYNFYLKSNCAPLPDNKRLLIKPDGNPYEIEHVVEKDINDNDDYVLPKSKKNNRTQIIGYWPLRGDFDIEYDNDAELLLADMEFKESDLPQQKELKLQVLEIYNSKLDERIYRKRTVIERGLLDSKAQMQKEKKRTKEEKELYAALKPLSRFHSPQHHEYFIQLLLEEQKLRQRLTKLQEWKALGLQNIEQVQEYEIEKNRRAKEMVKQESNSTTGIISMNNISSNNNTVTTEKLGKSLKTSKKDYKIKNKEEETDENKKLNIDTFVALDLLNEKEVEFCKNMKLPILFFLLIKRLLIMEVSNSNLNMLKDINELKLKGYKVGQLYDFFLSFDINQKDEFLNNGTVNTSYVKKNDGKRKKSKNNFDISNSKEIDGKEKLVVDDKDEKNDKNSSNNNNNNNNNNNNNNNNNNANVDNYNVYVDNNNSGNYSLMTLQGEVLNENEKKGKSKNEDKNKTSNLATKNSNKGCNKLKSPPKDDMNDINKDAKDIIIKNTNDMILTECVNDKNMQSIFVDNNLESENNDQLKENEVKGDELNLTEKELNEHILNTVVVDENDKKGKNEKGKNCETQKNMDSNLLQNEVDMKSNESLFNEKKKGSIKRKSSIINNLYDKVHENNENVDILENEVKDNVTVDDIKENKEIPNGITETFESIENIEEEKDMTMKDIKNDNKDDTKNDCDNEKDDDDYVAQEEILEDDKKRRKKKKEKKSEYADDKNDELNSIKINENECTSNDIEEDIKSIKSLRKKSYEKIKGFTAHLKTNSNNKKKTNDNFDEIEKETTVSVNINDSNNRKAKKKTPEKVETNNYQAHVEPLENNSKKKNTKMRKTSEYSVTRNESKINNNSDVYNDNSITKDDSNIDLDDKPSKSKKSISSTSTVILNKNEKGKRTKLTKEKATVDIPSNVDTKENDKKMKNFEANLKKKAKKRKGSVSLILNPKKSLKL