wanglab/gogpt-training-data huggingface dataset:
Protein: Desmoglein-4 (Cadherin family member 13) (Q86SJ6)
Organism: Homo sapiens (Human)
Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:21495994}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, desmosome {ECO:0000269|PubMed:12705872, ECO:0000269|PubMed:21495994}. Note=Colocalizes with JUP at desmosomes. {ECO:0000269|PubMed:21495994}.
Interaction partners:
- Keratin, type II cuticular Hb3
- Keratin, type II cuticular Hb6
- Plakophilin-1
- Desmoplakin
- Lysophosphatidic acid receptor 6
- Keratin, type II cuticular Hb1
- Plakophilin-3
- Trichohyalin
- Desmoglein-1
- Keratin, type II cuticular Hb2
Sequence:
MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ
Protein: Cell migration-inducing and hyaluronan-binding protein (EC 3.2.1.35) (Hyaluronan binding protein involved in hyaluronan depolymerization) (Q8WUJ3)
Organism: Homo sapiens (Human)
Function: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
Subcellular location: Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.
Interaction partners:
Sequence:
MGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKNDNWLVRHPDCINVPDWRGAICSGCYAQMYIQAYKTSNLRMKIIKNDFPSHPLYLEGALTRSTHYQQYQPVVTLQKGYTIHWDQTAPAELAIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGVFVRTLQMDKVEQSYPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSMKGCERIKIKALIPKNAGVSDCTATAYPKFTERAVVDVPMPKKLFGSQLKTKDHFLEVKMESSKQHFFHLWNDFAYIEVDGKKYPSSEDGIQVVVIDGNQGRVVSHTSFRNSILQGIPWQLFNYVATIPDNSIVLMASKGRYVSRGPWTRVLEKLGADRGLKLKEQMAFVGFKGSFRPIWVTLDTEDHKAKIFQVVPIPVVKKKKL
Protein: 2-(hydroxymethyl)glutarate dehydrogenase (EC 1.1.1.291) (Q0QLF5)
Organism: Eubacterium barkeri (Clostridium barkeri)
Function: Catalyzes the conversion of 2-formylglutarate to (S)-2-hydroxymethylglutarate. Has very low activity with (S)-3-hydroxyisobutyrate.
Interaction partners:
- Uncharacterized conserved protein YgbK, DUF1537 family
- Enamidase
- Pyruvate:ferredoxin oxidoreductase
- Pyruvate:ferredoxin oxidoreductase
- Uncharacterized protein
- Nicotinate dehydrogenase medium molybdopterin subunit
- Nicotinate dehydrogenase FAD-subunit
- Nicotinate dehydrogenase large molybdopterin subunit
- Nicotinate dehydrogenase small FeS subunit
- 6-hydroxynicotinate reductase
Sequence:
MEKSIKIGFIGLGAMGKPMAINLLKEGVTVYAFDLMEANVAAVVAQGAQACENNQKVAAASDIIFTSLPNAGIVETVMNGPGGVLSACKAGTVIVDMSSVSPSSTLKMAKVAAEKGIDYVDAPVSGGTKGAEAGTLTIMVGASEAVFEKIQPVLSVIGKDIYHVGDTGAGDAVKIVNNLLLGCNMASLAEALVLGVKCGLKPETMQEIIGKSSGRSYAMEAKMEKFIMSGDFAGGFAMDLQHKDLGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLGREDMSAVIKVWEQMTGVSVSGGQ
Protein: Aminoaldehyde dehydrogenase 1a (ZmAMADH1a) (EC 1.2.1.-) (4-trimethylammoniobutyraldehyde dehydrogenase AMADH1a) (EC 1.2.1.47) (Aminobutyraldehyde dehydrogenase AMADH1a) (EC 1.2.1.19) (Betaine aldehyde dehydrogenase AMADH1a) (EC 1.2.1.8) (Gamma-guanidinobutyraldehyde dehydrogenase AMADH1a) (EC 1.2.1.54) (C0P9J6)
Organism: Zea mays (Maize)
Function: Dehydrogenase that catalyzes the oxidation of several aminoaldehydes. Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively. Catalyzes the oxidation of 4-(trimethylamino)butanal and 4-guanidinobutanal to 4-trimethylammoniobutanoate and 4-guanidinobutanoate, respectively. Catalyzes the oxidation of betaine aldehyde to glycine betaine.
Interaction partners:
- Choline monooxygenase, chloroplastic
- Glucose-methanol-choline
- Proline dehydrogenase
- Proline dehydrogenase
- Delta-1-pyrroline-5-carboxylate synthase
- Delta-1-pyrroline-5-carboxylate synthase
- Delta-1-pyrroline-5-carboxylate synthase
- Ketose-bisphosphate aldolase class-II family protein
- ornithine aminotransferase
Sequence:
MASPAMVPLRQLFVDGEWRPPAQGRRLPVVNPTTEAHIGEIPAGTAEDVDAAVAAARAALKRNRGRDWARAPGAVRAKYLRAIAAKVIERKPELAKLEALDCGKPYDEAAWDMDDVAGCFEYFADQAEALDKRQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAVLKPSELASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSFETGKKIMASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLIHTKIAKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTGGVRPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGLAGAVISGDRERCQRLSEEIDAGCIWVNCSQPCFCQAPWGGNKRSGFGRELGEGGIDNYLSVKQVTEYISDEPWGWYQSPSKL
Protein: Cytochrome c1 2, heme protein, mitochondrial (Complex III subunit 4-2) (Complex III subunit IV-2) (Cytochrome b-c1 complex subunit 4-2) (Ubiquinol-cytochrome c reductase complex cytochrome c1 subunit 2) (Cytochrome c-1 2) (Q9FKS5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:18189341, ECO:0000269|PubMed:18305213}; Single-pass membrane protein {ECO:0000269|PubMed:18189341, ECO:0000269|PubMed:18305213}.
Interaction partners:
- Cytochrome b
- Cytochrome b-c1 complex subunit 6-1, mitochondrial
- Cytochrome b-c1 complex subunit 7-2, mitochondrial
- Cytochrome b-c1 complex subunit Rieske-1, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Cytochrome b
- Cytochrome b-c1 complex subunit 7-1, mitochondrial
- Cytochrome c oxidase subunit 1
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Cytochrome b-c1 complex subunit Rieske-2, mitochondrial
Sequence:
MVGGGVIRQLLRRKLHSQSVATPVLSWLSSKKANEDAGSAGLRAFALMGAGITGLLSFSTVASADEAEHGLECPNYPWPHEGILSSYDHASIRRGHQVYQQVCASCHSMSLISYRDLVGVAYTEEEAKAMAAEIEVVDGPNDEGEMFTRPGKLSDRLPEPYSNESAARFANGGAYPPDLSLVTKARHNGQNYVFALLTGYRDPPAGISIREGLHYNPYFPGGAIAMPKMLNDEAVEYEDGTPATEAQMGKDVVSFLSWAAEPEMEERKLMGFKWIFLLSLALLQAAYYRRLKWSVLKSRKLVLDVVN
Protein: Miranda, isoform C (A0A0B4KHS3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSFSKAKLKRFNDVDVAICGSPAASNSSAGSAGSATPTASSAAAAPPTVQPERKEQIEKFFKDAVRFASSSKEAKEFAIPKEDKKSKGLRLFRTPSLPQRLRFRPTPSHTDTATGSGSGASTAASTPLHSAATTPVKEAKSASRLKGKEALQYEIRHKNELIESQLSQLDVLRRHVDQLKEAEAKLREEHELATSKTDRLIEALTSENLSHKALNEQMGQEHADLLERLAAMEQQLQQQHDEHERQVEALVAESEALRLANELLQTANEDRQKVEEQLQAQLSALQADVAQAREHCSLEQAKTAENIELVENLQKTNASLLADVVQLKQQIEQDALSYGQEAKSCQAELECLKVERNTLKNDLANKCTLIRSLQDELLDKNCEIDAHCDTIRQLCREQARHTEQQQAVAKVQQQVESDLESAVEREKSYWRAELDKRQKLAENELIKIELEKQDVMVLLETTNDMLRMRDEKLQKCEEQLRNGIDYYIQLSDALQQQLVQLKQDMAKTITEKYNYQLTLTNTRATVNILMERLKKSDADVEQYRAELESVQLAKGALEQSYLVLQADAEQLRQQLTESQDALNALRSSSQTLQSEIANSFQERIDGDAQLAHYHELRRKDETREAYMVDMKKALDEFATVLQFAQLELDNKEQMLVKVREECEQLKLENIALKSKQPGSASLLGTPGKANRSNTTDLEKIEDLLCDSELRSDCEKITTWLLNSSDKCVRQDTTSEINELLSAGKSSPRPAPRTPKAPHTPRSPRTPHTPRTPRSAASTPKKTVLFAGKENVPSPPQKQVLKARNI
Protein: Complement C1q tumor necrosis factor-related protein 1 (Putative secreted protein ZSIG37) (Q9QXP7)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MGSCAQGFMLGCCLLLAITWGPILSLVPRVQEEQQEWEETEELPSPLDPVTRPEETREKYSPRQGEDLPTSRCYRCCDPSTPVYQTIPPPQINITILKGEKGDRGDRGLQGKYGKIGSTGPRGHVGPKGQKGSIGAPGNHCKSQYAAFSVGRKKALHSNDYFQPVVFDTEFVNLYKHFNMFTGKFYCYVPGIYFFSLNVHTWNQKETYLHIMKNEEEVVILYAQVSDRSIMQSQSLMMELREEDEVWVRLFKGERENAIFSDEFDTYITFSGYLVKPASEP
Protein: 7-carboxy-7-deazaguanine synthase (CDG synthase) (EC 4.3.99.3) (Queuosine biosynthesis protein QueE) (P64554)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
Interaction partners:
- 6-carboxy-5,6,7,8-tetrahydropterin synthase
- 7-cyano-7-deazaguanine synthase
- NADPH-dependent 7-cyano-7-deazaguanine reductase
- GTP cyclohydrolase 1
- Epoxyqueuosine reductase
- S-adenosylmethionine:tRNA ribosyltransferase-isomerase
- Uncharacterized sugar kinase YgcE
- NAD-dependent dihydropyrimidine dehydrogenase subunit PreT
- Queuine tRNA-ribosyltransferase
- Alkaline phosphatase isozyme conversion protein
Sequence:
MQYPINEMFQTLQGEGYFTGVPAIFIRLQGCPVGCAWCDTKHTWEKLEDREVSLFSILAKTKESDKWGAASSEDLLAVIGRQGYTARHVVITGGEPCIHDLLPLTDLLEKNGFSCQIETSGTHEVRCTPNTWVTVSPKLNMRGGYEVLSQALERANEIKHPVGRVRDIEALDELLATLTDDKPRVIALQPISQKDDATRLCIETCIARNWRLSMQTHKYLNIA
Protein: Zinc metalloproteinase-disintegrin-like ohanin (EC 3.4.24.-) (Snake venom metalloproteinase) (SVMP) (A3R0T9)
Organism: Ophiophagus hannah (King cobra) (Naja hannah)
Function: Snake venom zinc metalloproteinase that has hemorrhagic activity. Inhibits ADP-, TMVA- and stejnulxin-induced platelet aggregation in a dose-dependent manner (on washed platelet, but not on platelet rich plasm). Also specifically degrades alpha-chain of fibrinogen (FGA).
Subcellular location: Secreted.
Interaction partners:
Sequence:
MIQVLLVTICLVVFPYQGSSIILESGKVNDYEVVYPQKIPVLPKSKIQRREQKMYEDTMKYEFKVNGEPVVLHLERNKELFSKDYTETHYSPDGREITTSPPVEDHCYYHGYIQSDIDSTAILNACNGLKGYFRHHGEAYHIEPLKFSDSEAHAVYKYENIEKEDETPKICGVKHSTWESDEPIEKISQKKDFLEEKKYLELYIVADYVMFRKYGRNVTTIRMRVFDMVNYITVVYKALNIHVALIGFEIWSLKDKFVINASTKNNLLHFSIWRSTVLRKRNDNAQLLTGVDLNGYTLGSAYLKAMCDVLQSVGIVQDYSKSPYLVGAAMAHEIGHNLGMEHDTKTCSCMRGNCIMSPEEEGSDFPMEFSSCSLYDFQNYMLTDTPQCLINKPSNTSIIKNAVCGNYVEEEGEECDCGSPEQCENNCCEAATCKLKPGAKCAKGACCKKCQFKKAGAECRAARNECDLPEFCIGQSAECPMDRFHKNGHSCQNDQGYCFRGYCPTLAKQCITLWGSDAKVAPDECFQNNTNGNEYDYCKKTNNVIIPCKPTDVKCGRLYCTGGTENPSEGEKISSDPCKASYSEIEDIGMVDHRTKCGEKMVCSDGKCIPL
Protein: Streptokinase C (P00779)
Organism: Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Function: This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells.
Interaction partners:
Sequence:
MKNYLSFGMFALLFALTFGTVNSVQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQDISLKFFEIDLTSRPAHGGKTEQGLSPKSKPFATDSGAMSHKLEKADLLKAIQEQLIANVHSNDDYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLSGHVRVRPYKEKPIQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKNHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYRVKNREQAYRINKKSGLNEEINNTDLISEKYYVLKKGEKPYDPFDRSHLKLFTIKYVDVDTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEEREVYSYLRYTGTPIPDNPNDK
Protein: TNF superfamily member 11 (Tumor necrosis factor ligand superfamily member 11) (E7F3U1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Tumor necrosis factor receptor superfamily member 11A isoform X1
- Tumor necrosis factor receptor superfamily, member 11b.
- TNF receptor-associated factor 6
- Nuclear factor of-activated T cells 1.
- Cathepsin K
- CD40 molecule, TNF receptor superfamily member 5
- Sclerostin
- Sp7 transcription factor.
- TNF superfamily member 13b
- Tumor necrosis factor receptor superfamily member 1B precursor
Sequence:
MAANDYRAYLRNHIDMEEAPARAPHTGSTHRALIFGTLAVMALLQVASSVAILLHLTGYLREVDLASPQQSPNEEMHSETLIGDQMNSSTKDKTKKVPSAHLPIKTPIDLLPNENGLTQIAWDGMKAENLKRMKYKDNRIIVDSPGYYYVYAKTCFRYHEIHSSEKVNISNIELGQYIYHEKHSRSEPPTVLAKSSGTPEWNIKKYNKYCMEQGRGVRLEKDDRIYVKVSNAQLLDPAVEETYFGCFKISK
Protein: Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) (Q8K1N2)
Organism: Mus musculus (Mouse)
Function: Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86SQ0}. Membrane {ECO:0000250|UniProtKB:Q86SQ0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q86SQ0}. Cell projection, podosome {ECO:0000269|PubMed:23525008}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q86SQ0}. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments (By similarity). Localized to the myotube podosome cortex that surrounds the core (PubMed:23525008). {ECO:0000250, ECO:0000269|PubMed:23525008}.
Interaction partners:
- CLK4-associating serine/arginine rich protein
- Ppfia1 protein,-interacting protein
- CLIP-associating protein 2
- ELKS/Rab6-interacting/CAST family member 1
- KN motif and ankyrin repeat domains 1
- Filamin-C
- CLIP-associating protein 1
- Prickle-like protein 1
Sequence:
MAEDSHMQKQLEFQNGSLEEGFVVRSLENEPQNMMESLSPRKYSSSLKFKANGDYSGSYLTLSQPVSAKRSPSPMGTSVRSSPSLAKIQGSKQFCDGIDKNISMKPPISFLSSAASLGGYPLGKADLDHYTGRDSERSTRLSEKPPYSRYSSRNKSHDSVYFLGGLEGRKTSGSLLTMWNGNSLSCTGSSPISRSGAASMPSSPKQVRKMNLQDHSTLQPRLSRHKEPASENVSVRTRKYSGSSLSNMGAYSRSLPRLYKATDNQMSPLSLPPRSSLGNSRRGQLGEKDLPHSLVDSDNYLNFSSLSSGASPYKTCLSEGNPYVSSALSVPASPRVARKMLLASTSSDDFDRASYSGTSPSHSFISGEPDRVLVARRNFSCGSMELDDSDLESLRQSSETPQPVLRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPEGRRLSAGTTVADVQKINKELEKLQLSDEESVFEDALVCPDARYRCHRKGSLQDVDVAGFGNLGHSASFLAPRGSRSDELLGDLTRTPPSSSAAFLKATNESSYLSILPKTPEDIGEEQRTQELAAMEDARMVILNNLEELEQKIKDINDQMDESSRELDMECALLDGEQKSETAELMKEKEILDHLNRKITELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVARKEKISALKKQASHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLTGGKGFPINPNTLKEGYISVNEINESCGNSTNLSPSTQFPADADAAVTEPALAVPVSQPQSSEHFRSLEERKKQHKEGLYLSDTLPRKKTTPSLSPHFSSATMGRSTTPKAHLPLGQSNSCGSVLPHSLATMTKDSESRRMLRGYNHQQMSEGQRQKPEFYSRTASESNVYLNSFHYPDRSYKDQAYDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIREKQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCFHVSITEKTCRGYLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHEAKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Protein: Lysine-specific demethylase JMJ26 (EC 1.14.11.-) (Jumonji domain-containing protein 26) (AtJMJ26) (Protein JUMONJI 26) (Lysine-specific histone demethylase JMJ26) ([histone H3]-trimethyl-L-lysine monodemethylase JMJ26) (C0SUU8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function as histone H3 lysine demethylase and be involved in regulation of gene expression.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
Interaction partners:
- Histone-lysine N-methyltransferase ATX5
- Histone-lysine N-methyltransferase ATX4
- Lysine-specific demethylase JMJ28
- E3 ubiquitin-protein ligase JMJ24
- Histone H3-lysine
- Histone-lysine N-methyltransferase ATX2
- Histone-lysine N-methyltransferase ATX3
- At2g42780/F7D19.22
- Transcription factor jumonji
- Probable E3 ubiquitin protein ligase DRIPH
Sequence:
MEGEVATNGVILKHNGVKDISLETCWPEKKKPVEATSLSSGSSDIEEEISVECPKRVANQRRKRSKADEIKTKSSRKRKCDDENKCEENEKKQRSSVKKRATTWKEEEVVVDDEKKCEQQLQLVPSSKATSRSRSKKSVSVDTWLVNNEIDVSALSSRSESELSDSYLKTEYFNDCRSMTRSLKANLGELAICHQCSKGERRYLFICTFCEVRLYCFPCIKKWYPHLSTDDILEKCPFCRGTCNCCTCLHSSGLIETSKRKLDKYERFYHLRFLIVAMLPFLKKLCKAQDQEIETEAKVQDSMASQVDISESLCSNEERVFCNHCATSIVDLHRSCPKCSYELCLNCCQEIRGGWLSDRPECQLQFEYRGTRYIHGEAAEPSSSSVSEDETKTPSIKWNADENGSIRCAPKELGGCGDSVLELKRILPVTWMSDLEQKAETFLASYSIKPPMSYCRCSSDMSSMKRKAASRDGSSDNYLYSPDSLDVLKQEELLHFQEHWSKGEPVIVRNALNNTAGLSWEPMVMWRALCENVDSAISSNMSDVKAIDCLANCEVKINTLCFFEGYSKGRTYENFWPEMLKLKDWPPSDKFENLLPRHCDEFISALPFQEYSDPRSGILNIATKLPEGLLKPDLGPKTYVAYGTSDELGRGDSVTKLHCDMSDAVNILMHTAEVTLSEEQRSAIADLKQKHKQQNEKELQEQNGLEEEEVVSDEIVVYDETSGALWDIFKREDVPKLEEYLRKHCIEFRHTYCSRVTKVYHPIHDQSYFLTVEHKRKLKAEFGIEPWTFVQKLGEAVFIPAGCPHQVRNLKSCTKVAVDFVSPENIDECLRLTDEFRQLPKNHKAREDKLEIKKMVIYAVEQALKEVETLLLDRS
Protein: Protein STB2 (P46679)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Transcriptional regulatory protein SIN3
- Protein STB1
- Transcriptional regulatory protein RXT2
- Transcriptional regulatory protein UME6
- Histone deacetylase RPD3
- Transcriptional regulatory protein ASH1
- Chromatin modification-related protein EAF3
- Transcriptional regulatory protein SAP30
- Transcriptional regulatory protein DEP1
- Transcriptional regulatory protein RCO1
Sequence:
MVMADTIATGDKTSQFDGKHMQDLERIYSTRDTLDDNFFGERGQKDANGDYYDELNNEETNYSGSSYYGHSDDSEVVGLIKNDTVSQLPPLDSFIFPDSRALFLLDLGNYADLTYEEIIVHGFEIYIVEQWVACRNLSTLITSYTGNSQDTISGVRVVLPKDTSMWPGRFRLYFEELMEFARPKFTPKGTLFITNLSGVSFGLNLLHVECGDLRTIWKDFEVNFDLKNLHCGGRSANLLCPPTMASLDKFSQLFKIPTNGFIAQYPQMIQQQQPRLPEEEYKTVGNSKCRNTDSKSPVVEMVTLIQISLSYFNLLSKNYQTDGLLCEDTKRAIDEWWETYGKLYLGTEKPRNECTLGPTTVAGLISLILCCYFKLMIENCISSKDPFDEAGFFQGIYNFQKKHGLNKRKSRVYLDPRTLEKLFEVTAKVSSKDIFKLKKMVTSTVQDIIGKGNPINLSHKILTTDLDTLIHNIHGGSVGLLWKGKGHPRKCCTDISNEEFLKFNYQRGDPDGQIREREMLLEKFRLERIAYAQKHASKKVSSSSLDTSEDIGRTNAMPSSATVSSMFPNYDNTKYAYNFGINKLYQGEYYRRNSFPYCKDRTHDNIYEDLSELKEKSSRLYRCNSSSAVQNIVEKWDLPFDPSVVRIARDLLRMKYDIQAQQHIQEMDEHYMGKLNKEGTVGQYSKFNERYKRLQELYKKYSDGAKVFEGRFEDIDNKQQLLLHEMQELNSLSSRLKYDMRILEVRVRDIESSVAQFDSKLIGLKSSLQGQGKTGICSAIDPKSDKDEYDRCVNDLMTTNNPTYEALCLKMLSRRYFKDLKNDTVGWFRWLFGNNSLHNNASEDDRGIRV
Protein: CTCK domain-containing protein (Q9CVD4)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
DSISMYSLEANKVEHTCECCQELQTSQRNVTLRCDDGSSQTFSYTQVEKCGCLGQQCHALGDTSHAESSEQEFKSKESEEHGQQLASRVSEDMLGPFQ
Protein: vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.17.4.4) (F8W9H0)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
Sequence:
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRVQGTGLTVLTWFHPTPPLCQVGQGFRAGGACAGTGQHPQSIQQHIRLHLLHTTAIVRLPADTLGLCPDAAELPGVSRWFCLPGLDPVLRAL
Protein: Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) (Q14469)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Subcellular location: Nucleus {ECO:0000269|PubMed:28750047}.
Interaction partners:
- Fanconi anemia group F protein
- Fanconi anemia group A protein
- Fanconi anemia group G protein
- E3 ubiquitin-protein ligase FANCL
- Fanconi anemia group C protein
- Fanconi anemia group E protein
- Neurogenin-3
- Transducin-like enhancer protein 1
- Recombining binding protein suppressor of hairless
- Fanconi anemia group D2 protein
Sequence:
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN