wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor SOX-6 (SOX-LZ) (P40645)
Organism: Mus musculus (Mouse)
Function: Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:32442410}. Cytoplasm {ECO:0000269|PubMed:32442410}.
Interaction partners:
- BCL11 transcription factor A
- Transcription factor SOX-5
- Histone deacetylase 1
- Transcription factor SOX-9
- Catenin beta-1
- Erythroid transcription factor
- E3 ubiquitin-protein ligase TRIP12
- Aggrecan core protein
- Collagen alpha-1
- Krueppel-like factor 1
Sequence:
MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRFGRNLDPSEHGGGHSYNHRQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNNMGLSNCRTEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQMPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN
Protein: Interleukin-1 receptor-associated kinase 1 (A0A8I5ZRN5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAGGPGPGEPVVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSEQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPASVLPPSTGAPRPSSISAGSETEDWSPRKLQSSASTFLSPAFPGSQTHSESELLQVPLSDSLGPPLQSSAPSSIKPSPESPVSGLQRARPSPFCWPFCEISQGTCNFSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTVVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGFYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGANPSQSSTVARTCTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQRAVRTQGAKTKYLVYKRLEGLQAVPPWKLEVAGHGSPSPQENSYMSTTGSAQSGDEPWQPLVVTTRAPAQAAQQLQRSPNQPVESDESVPGLSATLHSWHLTPDSHPSPVSFREASCTQGGTTRESSLRSGPGFQPTTMEGSSMGSSSLLSSEPPQIIINPARQKMVQKLALYEEGVLDSLQLLSSGFFPGLDLEPEKRKRPEESDEFQS
Protein: GATA factor AREB beta (Q9HEV3)
Organism: Emericella nidulans (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASTTYATSSPAATTGGQGNNPPICQNCGTSKTPLWRRDELGSVLCNACGLFLKLHGRPRPISLKTDVIKSRNRVKTAGQGPKRKSGSAVDGNGLSSSRSEAGTPPLGVSQGYRRASRKMSPGHSDRSNSPVPPTDAHGLSALHQPLAQPHHNSNIAPQHLFDSVTAGDHTSQLPSVQLRQPSPTSTTAPVDRHHEPPQTYEDLLAANTSLKTRVSELDLINGLFRGRVAELEQSDATARRSEMILRDSEVRLRRSLDDAQRREEELKRRIAELERQLAERTNGANTSQENPLEPLAKRMKLSDVVEHDSNSPAKSPKSI
Protein: Cytochrome b559 subunit alpha (PSII reaction center subunit V) (Q6ENF6)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00642}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00642}.
Interaction partners:
- Photosystem II CP43 reaction center protein
- Cytochrome b559 subunit beta
- Photosystem II D2 protein
- Photosystem II CP47 reaction center protein
- photosystem II
- Photosystem II protein D1
- Photosystem II protein D1
- Uncharacterized protein
- Cytochrome b6-f complex subunit 4
- Cytochrome b6
Sequence:
MSGSTGERSFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTESRQGIPLITDRFDSLEQLDEFSRSF
Protein: Zinc finger protein 544 (Q6NX49)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MEARSMLVPPQASVCFEDVAMAFTQEEWEQLDLAQRTLYREVTLETWEHIVSLGLFLSKSDVISQLEQEEDLCRAEQEAPRDWKATLEENRLNSEKDRAREELSHHVEVYRSGPEEPPSLVLGKVQDQSNQLREHQENSLRFMVLTSERLFAQREHCELELGGGYSLPSTLSLLPTTLPTSTGFPKPNSQVKELKQNSAFINHEKNGADGKHCESHQCARAFCQSIYLSKLGNVETGKKNPYEYIVSGDSLNYGSSLCFHGRTFSVKKSDDCKDYGNLFSHSVSLNEQKPVHFGKSQYECDECRETCSESLCLVQTERSGPGETPFRCEERCAAFPMASSFSDCNIIQTTEKPSVCNQCGKSFSCCKLIHQRTHTGEKPFECTQCGKSFSQSYDLVIHQRTHTGEKPYECDLCGKSFTQRSKLITHQRIHTGEKPYQCIECRKSFRWNSNLIVHQRIHTGEKPYECTHCGKSFSQSYELVTHKRTHTGEKPFKCTQCGKSFSQKYDLVVHQRTHTGEKPYECNLCGKSFSQSSKLITHQRIHTGEKPYQCIECGKSFRWNSNLVIHQRIHTGEKPYDCTHCGKSFSQSYQLVAHKRTHTGEKPYECNECGKAFNRSTQLIRHLQIHTGEKPYKCNQCNKAFARSSYLVMHQRTHTGEKPFECSQCGKAFSGSSNLLSHHRIHSGEKPYECSDCGKSFRQQSQLVVHRRTHTGEKP
Protein: GEO05078p1 (LD15606p) (MIP08219p) (PolyA-binding protein interacting protein 2, isoform A) (PolyA-binding protein interacting protein 2, isoform B) (PolyA-binding protein-interacting protein 2) (Q9VG13)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Polyadenylate-binding protein
Sequence:
MLLKVPSVDWTDQIIYVVDDDESLSDIDDEPDFSEYMWMENEEEFDKNELQRLEEEEIMQECFEAMIEDELEEQINEWEKAKTDEQNTALSALPKSQCDVEKSVLNPMADEFVPRCHVIDFPAS
Protein: Aminopeptidase (EC 3.4.11.-) (B0BCY7)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Interaction partners:
Sequence:
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLVVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
Protein: Potassium voltage-gated channel subfamily Q member 5 (A0A8I5ZNI9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MPRHHAGGEEGGAAGLWVRSGAAAAAGGGRPGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAAALGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFVYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTNQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKTVIDADTALGIDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALTLTSFQIPPFECEQTSDYQSPVESKDLSSSAQNSGCLSRSASANISRGLQFILTPNEFSAQTFYALSPTMHSQTTQVPMSQNDGSSVVATNNLANQISAAPKPAAPTTLQIPPPLSAIKHLSRPEPLLSNPPGVHESISDVTTCLVASKENVQFAQSNLTKDRSLRKSFDMGGETLLSVRPMVPKDLGKSLSVQNLIRSTEELNLQFSGSESSGSRGSQDFYPKWRESKLFITDEEVGAEETETDTFDGTPPPAGEAAFSSDSLRTGRSRSSQNICKTGDSTDALSLPHVKLN
Protein: Protein saf1 (O74517)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor dre4
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing factor cdc5
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein-associated protein B
- Pre-mRNA-splicing factor spp42
- Pre-mRNA-splicing factor cwf17
- Pre-mRNA-splicing factor cwf11
- Pre-mRNA-processing factor 19
Sequence:
MLSKRGLNPVQAESRKKKKREQIKVREERAKRHEERLSHRNMSQMERQLSELTQLESSQALNAHDKQLLQNLQRDMAIMKKKNIHGHRVGRVESDKTKEAERQHKPRKPFIPKNPKRSIYYDPIFNPYGVPPPGMPYREKEELSSETDESVIDIPLPSEEYPFEDPKPREKKNKSFKPKHHKKQDINASSAQPKSTTTTEAAANTKDIEEETMIEYSAQPVVRDLRQEAAQFLPAAFQRQKLAKGQKIGQPDRDVSSQVQEDKDEEIDNFYKEIGGYL
Protein: DNA polymerase iota (J3KSW2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLKALNTAKKGLIDYYLMPSLSTTSRSGKHSFKMKDTHMEDFPKDKETNRDFLPSGRIESTRTRESPLDTTNFSKEKDINEFPLCSLPEGVDQEVFKQLPVDIQEEILSGKSREKFQGKGSVSCPLHASRGVLSFFSKKQMQDIPINPRDHLSSSKQVSSVSPCEPGTSGFNSSSSSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAFHSFPNLQSEQLFSRNHTTDSHKQTVATDSHEGLTENREPDSVDEKITFPSDIDPQVFYELPEAVQKELLAEWKRAGSDFHIGHK
Protein: histone acetyltransferase (EC 2.3.1.48) (Q9W1A9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Bromodomain-containing protein homolog
- Chromatin modification-related protein MEAF6
- Inhibitor of growth protein 5
- histone acetyltransferase
- Protein chiffon
- Transcriptional adapter 2b
- Transcriptional adaptor 3, isoform C
- Taiman, isoform G
- SAGA-associated factor 29kDa
- Enhanced level of genomic instability 1
Sequence:
MMRESAHDINMDTWNQWILEAISKIRSQKQRPSVQRICQAIGTHHKFHEDIVAEKLEKAVESGAVIKVYNKGLHSYKAPMAKRRVKVDKNTNLYKLVAKAVHDLGECEGSTIKSIENYIQKFNCIDLSPNVDFKAVIKASIKKAVDAGFLIQEGKLYKKGKSLTTPRKCAPVSEVVIKGEESCTHCSGNSQKNLNGIPEPLSSCKQCGISLHTTCANIAGRCKSQSYVLLYMLVTKGTIWDCQNCADCAVCKMRNRGPCLLQCFVCKDHFHLTCLDTIPDKKPKHPYRCKTCSKQGFDTPKLVKKDNSRIKMEAERMTPSYKYASNKRQSIKKDGNIESPSTSKLCVYNDGNGQRRKVPASLSSRKMNHSEDQFEFPSKQKRSQILQGGYLASQETRKRTFSDLSSTSSSSESEDEDDEDDDRNRNGDDNDQDESTSSDSCTSSSSDSDSSESSSDTSEWDDEYDEEEDYDTDRSTIREKNVFESGKQSCAKLSTGDGLGSPQNNELGSENWGFAAVAKNPIDIFVKSKHNSNVKGIGYSKPAASTFATSPAANRVQKSTPVASSTPEKNSAPIGGMTIKRQTANGQKKKIVPLKSMPLEAGKSYEKCEDDIPYLTEETVMKVQLLEEIERSRETHSQADGKREMNNDEDAPGESTKRANPFENQPLPPGVTATDVELYQEVLHKAVVQMSNNHIEKVNDVSLKSGQNTQSPKSIQIGKWDIETWYSSPFPQEYARLLKLFLCEFCLKYTKSRSVLDRHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFYILTKNDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGRFLIDFSYLLSREEGQLGTPEKPLSDLGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGLAISDIALAFELLNFIKLRKNDGDIRYQINVKIEWKKVLAHHNKMANSKTRIIIEPDCLRWSPLLSVSKLPNIIKPISNREYLSNQMETNSSFKEINEDKISVKQGVSTSSKVNQESSELSTKNRGPSSEKLIDERENQRKRAYPEEFLKSASNEAKKPKLTAPQPNLEDQSFGELSDSSDCKSSKDLSEQLTKRAQRLAKRNDLIPHTNKRKHFDRPLENNTTSTDHNPPAQSQADTAGTENGHKSEETAAKENCKNVVEKEHVDKPVNIMPKLRGKQSNGKRSEEPQFNENPTSDPVAVASLSPAKEITREPVKVAKTESPGKNQESAKHDAEPNSVSDQVLDAVAKKTKKTLFSDVASYNTEDVKYNSEEKPMAIAQEPKESPTEAGIKETKPLEVPEQKAKAKSPEKPATVAETVLQHVHAPVNTEKISTEESKLELDVHYLKLSPDSALNPPVASVQKPVPEPPAPKEKAKDLQAAQPSEALQKQPEIEMVKKTETKTETPVSNPPSNRTDVSSLVEQPVKAAPEKVEQPMVKEAVDIKDKALKKPVPDVPVVKPEATSCEKKIDHSKTKVFHEKEAIKTDQQLVQVKEEEKSNARAPSAPIPIRDKIQLKGNEHAQLQNSIPSQFPLNQMPNYHTSQYWQWEYYGYNLSHLDASQKGQKQFHKDLATTMAYTHNFTQNLYQSANLAMQHAHHQMHQTKEKHKVERKNSGKKEEQNKVVSSVNVVSTAREDAHVQHCNEYAANNQAALYNQKCASQQKQAQQMKSLANVQNPVPRQSNSNAPESTVLMPNPVISQAGSVPAKQKVEHGVNSTSVISREGKLNKIGHSNIHATAQHANLQVGGGQSDVNPNMVYNTESSANSAMQHYDCGISAQINMDSPANIGSAIAHGPQEISATSNVHMHQPHRQFSDCSMQNQPVTTPMHMSIQNSHMQQQNNLNLNLAPEGSSNINLLSNPQHQHQSRKLNAQADIAVSSPTPSHRATTPKQIRSGNTQQRDAKNAAPPTTTTNTHHQIPQGGAAANISKSHHDSLHNLQFSQHGHQQNMQPIDYVPIPQISQNFSANPSNYDIVGMPAVIQQRMSLNGSVHSLANSHQRIEQPSSACAVNNFYLQNNMPAAENAPRVPVSSSLGGPPTAGNNDQRQAGQDSITTANSSGATASLAGNLCSLSKLQQLTNCLESQPCNTSPGAQVNLAPSPHHPIPPNSTPPPHLLMQNRNISTPPNMLQTQVTPLQYKYYPGNMNIPPITSAQNTSRNTRNTPSAPVQHTSTPMGSGNNRTANVHISPNLMAPYGAINSYRMSPQQSPPTGSYSSGGDYPNSQIPMQMMNMQSQYQDACVLQRGTPSNPMYPTYSPYLPLNGSIRR
Protein: Secretin receptor (SCT-R) (P23811)
Organism: Rattus norvegicus (Rat)
Function: Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:7476911, ECO:0000269|PubMed:9506976}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47872}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q5FWI2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47872}.
Interaction partners:
- Secretin
- Neuroendocrine secretory protein 55
- Guanine nucleotide-binding protein G
- Pituitary adenylate cyclase-activating polypeptide
- Somatoliberin
- Parathyroid hormone
Sequence:
MLSTMRPRLSLLLLRLLLLTKAAHTVGVPPRLCDVRRVLLEERAHCLQQLSKEKKGALGPETASGCEGLWDNMSCWPSSAPARTVEVQCPKFLLMLSNKNGSLFRNCTQDGWSETFPRPDLACGVNINNSFNERRHAYLLKLKVMYTVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDVTYCDAHKVGCKLVMIFFQYCIMANYAWLLVEGLYLHTLLAISFFSERKYLQAFVLLGWGSPAIFVALWAITRHFLENTGCWDINANASVWWVIRGPVILSILINFIFFINILRILMRKLRTQETRGSETNHYKRLAKSTLLLIPLFGIHYIVFAFSPEDAMEVQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWRQWHLQEFPLRPVAFNNSFSNATNGPTHSTKASTEQSRSIPRASII
Protein: Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] (P14791)
Organism: Gallus gallus (Chicken)
Function: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P09601}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}.
Interaction partners:
- Biliverdin reductase A
- Ferrochelatase, mitochondrial
- Glutamate--cysteine ligase
- Ceruloplasmin
- Frataxin.
- Hephaestin
- Protoheme IX farnesyltransferase
- Heme oxygenase
- BZIP domain-containing protein.
- Holocytochrome c-type synthase
Sequence:
METSQPHNAESMSQDLSELLKEATKEVHEQAENTPFMKNFQKGQVSLHEFKLVTASLYFIYSALEEEIERNKDNPVYAPVYFPMELHRKAALEKDLEYFYGSNWRAEIPCPEATQKYVERLHVVGKKHPELLVAHAYTRYLGDLSGGQVLKKIAQKALQLPSTGEGLAFFTFDGVSNATKFKQLYRSRMNALEMDHATKKRVLEEAKKAFLLNIQVFEALQKLVSKSQENGHAVQPKAELRTRSVNKSHENSPAAGKESERTSRMQADMLTTSPLVRWLLALGFIATTVAVGLFAM
Protein: Melanocortin receptor 5 (MC5-R) (MC-2) (P33032)
Organism: Homo sapiens (Human)
Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Pro-opiomelanocortin
- Melanocortin-2 receptor accessory protein 2
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
Protein: Myelin basic protein (I3ITP3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Myelin membrane {ECO:0000256|ARBA:ARBA00004392}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004392}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004392}.
Interaction partners:
- DMalpha2b
- Claudin
- BR serine/threonine kinase 2b.
- Myelin basic protein
- Oligodendrocyte lineage transcription factor 2.
- Transcription factor SOX-10
Sequence:
MATASTSGQNPFGLGRKKKAPGVLDQISRFFGGDKKRKGKGSFRGHLSSSPQRPHHSSTRRRGDVNPVVHFFRSFVSSPRPKSRWRELLGLASPSARGSESIRSPQRRRREQNTLSRIFNLGESRSRSPPKRWSTIF
Protein: Dorsal root ganglia homeobox protein (Paired-related homeobox protein-like 1) (A6NNA5)
Organism: Homo sapiens (Human)
Function: Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Interaction partners:
- Repulsive guidance molecule B
- Repulsive guidance molecule A
Sequence:
MFYFHCPPQLEGTATFGNHSSGDFDDGFLRRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGASDQEPGAKEPMAEVTPPPVRNINSPPPGDQARSKKEALEAQQSLGRTVGPAGPFFPSCLPGTLLNTATYAQALSHVASLKGGPLCSCCVPDPMGLSFLPTYGCQSNRTASVATLRMKAREHSEAVLQSANLLPSTSSSPGPVAKPAPPDGSQEKTSPTKEQSEAEKSV
Protein: Uncharacterized protein (Q57Y16)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYFEEEENNDDYNKAEGDESPHSRASSNVSDMPMPPLPPPTPPADVYGLATEEIYSIIKELRRQIDDPTAHHDIKAMLKKEPSILLAVTRVLHESGLLRRGVVNAHGQVEEQIVPLPEAPAPPLPTGYSSWV
Protein: Lipase member H (LIPH) (EC 3.1.1.-) (LPD lipase-related protein) (Membrane-associated phosphatidic acid-selective phospholipase A1-alpha) (mPA-PLA1 alpha) (Phospholipase A1 member B) (Q8WWY8)
Organism: Homo sapiens (Human)
Function: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Subcellular location: Secreted {ECO:0000269|PubMed:12963729}. Cell membrane {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12963729}; Peripheral membrane protein.
Interaction partners:
- Lysophosphatidic acid receptor 6
- POU domain, class 2, transcription factor 3
- Lysophosphatidic acid receptor 3
Sequence:
MLRFYLFISLLCLSRSDAEETCPSFTRLSFHSAVVGTGLNVRLMLYTRKNLTCAQTINSSAFGNLNVTKKTTFIVHGFRPTGSPPVWMDDLVKGLLSVEDMNVVVVDWNRGATTLIYTHASSKTRKVAMVLKEFIDQMLAEGASLDDIYMIGVSLGAHISGFVGEMYDGWLGRITGLDPAGPLFNGKPHQDRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNGGLDQPGCPKTILGGFQYFKCDHQRSVYLYLSSLRESCTITAYPCDSYQDYRNGKCVSCGTSQKESCPLLGYYADNWKDHLRGKDPPMTKAFFDTAEESPFCMYHYFVDIITWNKNVRRGDITIKLRDKAGNTTESKINHEPTTFQKYHQVSLLARFNQDLDKVAAISLMFSTGSLIGPRYKLRILRMKLRSLAHPERPQLCRYDLVLMENVETVFQPILCPELQL
Protein: E3 ubiquitin-protein ligase BIG BROTHER (EC 2.3.2.27) (Protein ENHANCER OF DA1-1) (RING-type E3 ubiquitin transferase BIG BROTHER) (Q8L649)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase that limits organ size, and possibly seed size, in a dose-dependent manner. Negatively regulates the duration of cell proliferation in leaves and petals independently of the major phytohormones (e.g. auxin, cytokinin, gibberellin, brassinosteroids, ethylene, abscisic acid, jasmonic acid), probably by targeting growth stimulators for degradation. Limits the proliferation of root meristematic cells. Polyubiquitinates DA1. Involved in the promotion of leaf senescence, in addition to its function in restricting plant growth. Possesses E3 ubiquitin-protein ligase activity in vitro.
Interaction partners:
- E3 ubiquitin-protein ligase DA2
- Ubiquitin carboxyl-terminal hydrolase 15
- Protein SDA1
- Protein SDA1
- Cytochrome P450 78A5
- Protein TIFY 4A
- Cytochrome P450 78A6
- Protein DA1-related 1
- GRF1-interacting factor 1
- Protein TIFY 4B
Sequence:
MNGDNRPVEDAHYTETGFPYAATGSYMDFYGGAAQGPLNYDHAATMHPQDNLYWTMNTNAYKFGFSGSDNASFYGSYDMNDHLSRMSIGRTNWDYHPMVNVADDPENTVARSVQIGDTDEHSEAEECIANEHDPDSPQVSWQDDIDPDTMTYEELVELGEAVGTESRGLSQELIETLPTKKYKFGSIFSRKRAGERCVICQLKYKIGERQMNLPCKHVYHSECISKWLSINKVCPVCNSEVFGEPSIH
Protein: Protein SLOW WALKER 2 (Protein EMBRYO SAC DEVELOPMENT ARREST 25) (F4IDC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with NOC2, probably involved in pre-ribosome export from the nucleus to the cytoplasm. Required for coordinated cell cycle progression during female gametophyte and pollen development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Nucleus, nucleolus {ECO:0000269|PubMed:19734265}.
Interaction partners:
- Nucleolar complex-associated protein 2
- Protein REBELOTE
- Nucleolar complex-associated protein 3
- rRNA biogenesis protein RRP5
- Expressed protein family protein)
- DEAD-box ATP-dependent RNA helicase 16
- Pescadillo homolog
- Ribosome production factor 2 homolog
- Peter Pan-like protein
- AT5g04600/T32M21_200
Sequence:
MSKIKPLSKSSQDLSLLTSDIASFASSIGLASALPSSGFNDTDFRKPAKSKTQKRKKPKKDQQHKDEDEEGEPKSNIGNEKGKDFGARKQNKDAPVKQTLQPKPKPGFLSIDDESTGYKKKRFDEFKSLPKLPLVKASLLSSEWYNDAAEFEEKVFGGRKVAVANKEDFKGVVEKKRELGERLMWQYAEDFATSKGKGGDMKMVISAQKSGTVADKITAFEIMVGENPIANMRSLDALLGMVTSKVGKRFAFKGLKALSEILIRLLPDRKLKSLLQRPLNIIPENKDGYSLLLFWYWEDCLKQRYERFVTALDESSKDMLPELKDKALKTIYFMLTSKSEQERKLLVSLVNKLGDPQNKSASNADYHLTNLLADHPNMKAVVIDEVDSFLFRPHLGLRAKYHAVNFLSQIRLSHKGEDPKVAKRLIDVYFALFKVLTTEANRKQGADDKGAADKKKSNPKDTKQEVSTDSPIELDSRILSALLTGVNRAFPYVSTDEADDIIESQTPVLFKLVHSANFNVGVQSLMLLDKISSKNKIVSDRFYRALYSKLLLPSAMNSSKAEMFIGLLLRAMKNDINIKRVAAFSKRVLQVALQQPPQYACGCLFLLSEVLKSRPPLWKMVVQRESVEEEEDIEHFEDVIEGDDVDPNKKAENDENVVEVDHDGVEKSSRDGDSSSDDEEALAIRLSDEEDDNASDDSEELIRNETPQLEEVMEVSNDMEKRSQPPMRPSSLPGGYDPRHREPSYCNADRASWWELGVLSKHAHPSVATMAGTLLSGTNIVYNGNPLNDLSLTAFLDKFMEKKPKQNTWHGGSQIEPSKKLDMSNRVIGAEILSLAEGDVAPEDLVFHKFYVNKMTSTKQSKKKKKKKLPEEEAAEELYDVNDGDGGENYDSDVEFEAGDESDNEEIENMLDDVDDNAVEEEGGEYDYDDLDGVAGEDDEELVADVSDAEMDTDMDMDLIDDEDDNNVDDDGTGDGGDDDSDGDDGRSKKKKKEKRKRKSPFASLEEYKHLIDQDEKEDSKTKRKATSEPTKKKKKKKSKASE