wanglab/gogpt-training-data huggingface dataset:
Protein: Atrochrysone carboxyl ACP thioesterase (ACTE) (EC 3.1.2.-) (Trypacidin synthesis protein B) (Q4WQZ6)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Atrochrysone carboxyl ACP thioesterase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC. The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC. The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone. The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodin anthrone to emodin. Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin. Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (By similarity). Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH. Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin. Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death. The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway.
Interaction partners:
- Atrochrysone carboxylic acid synthase
- Oxidoreductase tpcG
- Trypacidin cluster transcriptional coactivator tpcD
- Anthrone oxygenase tpcL
Sequence:
MLALHQTQRDVPCSEVHDALGLQGARSIYFGRPTGRSILSDPIRPRPMPTVTVIIYSDIRFLLEFPSVFLCAYVLPVQRTVIMANEKRGGYRQINQALNICAWEGYLNEQHARLPTLEDVEQISPRVLRVLGQNEGKVRRADGYYTCSSRLIEGPQFTLQGTNTYIVGTGRHRLLIDTGQGIPEWASLISSTLAGSSIELSHVLLTHWHGDHTGGVPDLLRMYPDLSDSIYKHTPGKGQKPISDGQTFRVEGATVRAVHTPGHSHDHMCFILEEENAMFTGDNVLGHGSSAVEVLSTWMSSLRMMQSLRCAVGYPAHGAVIRDLPSKLDLELTQKARREDRVVETLKQMKTETQRNGARGKGSVTVQQLVTAMHGHDLDEQVRTMALEPFVDEVLRKLAQDDRVAFEVRGGQKKWFAIEYT
Protein: FERM domain-containing protein B (Q55E74)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- FERM domain-containing protein A
Sequence:
MESSFEASKSLNENRDDIELIPTQSQGSPSLSSSSTITSTSRLGSNQVLIRIYFIDDTHKTLSIDPNNTTGDQLWEMVSEKLGINNRDSECFFVWAQNDEIEWLLFNHQNISEVIKNWGILKKRYCNTEENSPSSSTSSPILSGLSSIRGKKSNASSTSNANDGSGSGSGSGSGSGSGSGTSTPNSPKGGLSGFLTLGRKNKAQSPQLQSQSSSLSTTIASEHASKLRSSFPTLGEEGQFRLVYRPTSVLPLELERSINTAEATHLFYIQAIHNVINSNYPCEEDVALKLASIQLQVLVGDQKMEHQDHFKESISRYIPSHLLSKRKAEEWEQLVIPQHSLLRGSDSLQLKRAYLETCQRWAYYGSTFFKAKYIPANTSFFTQEFQGKVSIGINGNGFHIIDPKEMKMVSYSYRDIIAWDSTSNSFTIKFKIGQDKKFETKPYIFKTPQGELINDLISDWSEEWESKEKKNNKDSKKK
Protein: Diapause-specific peptide (DSP) (Diapausin) (Q8T0W8)
Organism: Gastrophysa atrocyanea (Leaf beetle)
Function: Has antifungal activity against T.rubrum. Blocks voltage-dependent N-type calcium channels (Cav2.2 / CACNA1B).
Subcellular location: Secreted {ECO:0000269|Ref.2}.
Interaction partners:
Sequence:
MGAALKMTIFLLIVACAMIATTEAAVRIGPCDQVCPRIVPERHECCRAHGRSGYAYCSGGGMYCN
Protein: Regulator of G-protein signaling 11 (RGS11) (P49807)
Organism: Rattus norvegicus (Rat)
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Interaction partners:
Sequence:
EACEELRFGGQAQVPTLVDSVYQQFLAPGAARWINIDSRTMEWTLEGLRQPHRYVLDAAQLHIYML
Protein: Probable alcohol dehydrogenase EutG (EC 1.1.1.1) (Ethanolamine utilization protein EutG) (P41795)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Probably acts on the acetaldehyde produced by the degradation of ethanolamine, producing ethanol.
Subcellular location: Bacterial microcompartment {ECO:0000305|PubMed:23585538}.
Interaction partners:
- Acetaldehyde dehydrogenase
- Propanal dehydrogenase
- Ethanolamine utilization protein EutJ
- Aldehyde dehydrogenase B
- Ethanolamine ammonia-lyase small subunit
- Bacterial microcompartment shell vertex protein EutN
- Probable acetate kinase EutP
- Bacterial microcompartment shell protein EutL
- Ethanolamine ammonia-lyase reactivase EutA
- Probable ethanolamine permease EutH
Sequence:
MQAELQTALFQAFDTLNLQRVKTFSVPPVTLCGLGALGACGQEAQARGVSHLFVMVDSFLHQAGMTAPLARSLAMKGVAMTVWPCPPGEPCITDVCAAVAQLREAACDGVVAFGGGSVLDAAKAVALLVTNPDQTLSAMTEHSTLRPRLPLIAVPTTAGTGSETTNVTVIIDAVSGRKQVLAHASLMPDVAILDAAVTEGVPPNVTAMTGIDALTHAIEAYSALNATPFTDSLAIGAIAMIGKSLPKAVGYGHDLAARENMLLASCMAGMAFSSAGLGLCHAMAHQPGAALHIPHGQANAMLLPTVMGFNRMVCRERFSQIGRALTNKKSDDRDAIAAVCELIAEVGQSKRLADAGAKPEHYSAWAQAALEDICLRSNPRTATQAQIIDLYAAAG
Protein: Retrotransposon hot spot (RHS) protein, putative (Q584M8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNQQVPIEGRGDIEGRRRENEEAARNDAEPPAVQQRVENNNQPQWSLFSRVDAVLLEGRVHPENVSVNDFLRRNFGRRYNVNEENNVSMFVFVLEPEEYINDVNALNLIFATAEYKVYKRFVSVYGFFEDEGILDLQQWQQADEVVKAGLQVNIRGLRDGERLWIVVNALLNNALNVALERAAQTAASAVEIKGVYDSIYNAKWSYVMSGYDEEPLGMKVFDGRPPHMWTKEEVDITPLPANVDARVPERPYGLEIFVLTSEKGWPYNRFASRDVNIRKNNFKHVYIRREIMRVWYIIQRGLQAWWVEKTAQRTPIHIVIGTPGIGKSYGVGSFLLHSLLHFNDGMLDVVAYFVGEIAFLIYNKKPGEEGRVEKYVVSKNAITAMDALENKRGHIIVDIGNDLLKPPGELRHLSWGVTVLTSPDTAHYEEWAKDTGDRQIIINCDDVRDMKAFVAWKKLCVLSEEVPRDKTKQQLMEDLESEWKIVEERIDMVGPLPRFVFSVSDYDARLESVRKEARQLDSDNGKKYDKIISKSKGWQNDKVTHKLVKIVRVSSGTVNVDSYRCRSLSVNIWNMLICTLFGILIVEMTSKEITLSDECVGANAFERLALLSLLFPRVFKVIADNLKYLRRGREIADRRNILNDMAPQQLRLIGQKALPAARQQPIDNCEYMVLYLPATGNEPVVDGFFFVEGRFRRNRDGAAPPTTPNIAVLLQVTKSERHPTTTDKVQKFRKNMERYFSDWGAFSRNMVWEMIYINSVNGGTITIRQLCEGPPDRDQGEDGGPLGPQTFWESIDQFQVTLKETMQAELIRAYRRESGMRDAPALIGLAGRRRAREEVVEGRGDVAMDDVEGGEDA
Protein: Fgr6-10p (A0A1D8PMC4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MSEVPNQESPSSSIFKQSNASTSTKIHGAPSSSQIANVDFNTLRKLNSNTSFSSNLTNSTTKTSNALSRLFTRNKSSSNISIHPSSSDDDSSPKTLRESTSPSESSKSVSGNKLRIAKKLKFPKNQSSWKPDLFLDTSSTISEDSSSFRKVITGNSLNEMNKSRKSSMSSPMSTTFHSLFHRSHHNGSNLQRDTNQVATGTTPLSGKFDDFSKASKTTLCLSSNSSNSIISNPELAQIYNFTNPNISIEDGETNLDHINSSFLDIHKKMLVPADSFIQNKLNKYHQTEVGLGIYESELDHDKDSKIYSNLYHYLKPLFTPSFSISDSGQKGRMRPILGASVEEIANFVKESFCLHQHNHDKSFRSKTRSSVSSLGREKVEDFDYRQLSNLFEKLMALLSHNLQTADSSEVSLQALILNAWKYYNAYVRFYLLSIFQPLQLHLNELSMRGPNGSTVTRIDDLLLVSFRKVFITEQGIGSGDRETSQFLGNAESEDLTGNGLLTSTLAVLSSIS
Protein: Serine/threonine-protein kinase HRK1 (EC 2.7.11.1) (Hygromycin resistance kinase 1) (Q08732)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in regulating the activity of the plasma membrane proton pump PMA1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Transcriptional activator HAA1
- Polyamine transporter 2
- Polyamine transporter 3
- 10 kDa heat shock protein, mitochondrial
Sequence:
MPNLLSRNPFHGHHNDHHHDRENSSNNPPQLIRSSKSFLNFIGRKQSNDSLRSEKSTDSMKSTTTTTNYTTTNLNNNTHSHSNATSISTNNYNNNYETNHHHNISHGLHDYTSPASPKQTHSMAELKRFFRPSVNKKLSMSQLRSKKHSTHSPPPSKSTSTVNLNNHYRAQHPHGFTDHYAHTQSAIPPSTDSILSLSNNINIYHDDCILAQKYGKLGKLLGSGAGGSVKVLVRPTDGATFAVKEFRPRKPNESVKEYAKKCTAEFCIGSTLHHPNVIETVDVFSDSKQNKYYEVMEYCPIDFFAVVMTGKMSRGEINCCLKQLTEGVKYLHSMGLAHRDLKLDNCVMTSQGILKLIDFGSAVVFRYPFEDGVTMAHGIVGSDPYLAPEVITSTKSYDPQCVDIWSIGIIYCCMVLKRFPWKAPRDSDDNFRLYCMPDDIEHDYVESARHHEELLKERKEKRQRFLNHSDCSAINQQQPAHESNLKTVQNQVPNTPASIQGKSDNKPDIVEEETEENKEDDSNNDKESTPDNDKESTIDIKISKNENKSTVVSANPKKVDADADADCDANGDSNGRVDCKANSDCNDKTDCNANNDCSNESDCNAKVDTNVNTAANANPDMVPQNNPQQQQQQQQQQQQQQQQQQQQHHHHQHQNQDKAHSIASDNKSSQQHRGPHHKKIIHGPYRLLRLLPHASRPIMSRILQVDPKKRATLDDIFNDEWFAAIAACTMDSKNKVIRAPGHHHTLVREENAHLETYKV
Protein: Tubulin polyglutamylase complex subunit 1 (PGs1) (p32) (Q99MS8)
Organism: Mus musculus (Mouse)
Function: Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:12972506}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:12972506}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:12972506}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000269|PubMed:12972506}. Cell projection, axon {ECO:0000269|PubMed:12972506}. Cell projection, dendrite {ECO:0000269|PubMed:12972506}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12972506}. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes. {ECO:0000269|PubMed:12972506}.
Interaction partners:
- Leucine-rich repeat-containing protein 49
- Tetratricopeptide repeat domain 13
- Ciliogenesis-associated TTC17-interacting protein
- Nicolin-1
- Polyglutamylase complex subunit TTLL1
Sequence:
MAALPVPLPPTKMAAVEKRRPAVAPAANFPDSGRTSVSQAAAAAESEEDFLRQLGVTEMLRAALLKVLEIRPEEPIAFLAHYFENMGLRSPTNGGAGEPPGQLLLQQQRLGRALWHLRLAHHSQRTAFNNNVSVAYECLSASGRKKKPGLDGRTYSELLKRVCRDGGAPEEVVAPLLRKIQCRDHEAVPLGIFRTGMLSCFVLLEFVARAGALFQLLEDPGQAVADRRVGQAVLDTLEGALSAGDMATAPTHYLEAGSRLGPDNLARALDRAASGRRPSVPMAREEFLEKAAALFIAKVKPVG
Protein: Ribosomal L18p/L5e family protein (F4HUG8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable inactive leucine-rich repeat receptor-like protein kinase At3g03770
- Probable protein phosphatase 2C 79
- 16 kDa phloem protein 1
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D
- Mitogen-activated protein kinase kinase kinase YODA
- Splicing factor Cactin
Sequence:
MILGMAALTSLSTVQFRVSDILGTRLKPYPQFPIRITTMSVVKPFVIEARGNTRVESPKTRNRRSRKKFTGTQTKPRLSVFCSDKQLYAMLVDDFNKKCLFYASTLQKSIRGDPPCTVIEAAKRVGEELIKASIDLKINEISSYDRNGNKRGERMQAFEIAIAQHGFLP
Protein: Scribble planar cell polarity protein (H0YCG0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEGEGHGSGVGVGSRLVWPDPPCPPAARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRPGRRGLGPVPS
Protein: RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) (Q5T8P6)
Organism: Homo sapiens (Human)
Interaction partners:
- Zinc finger C3H1 domain-containing protein
Sequence:
MVSKMIIENFEALKSWLSKTLEPICDADPSALAKYVLALVKKDKSEKELKALCIDQLDVFLQKETQIFVEKLFDAVNTKSYLPPPEQPSSGSLKVEFFPHQEKDIKKEEITKEEEREKKFSRRLNHSPPQSSSRYRENRSRDERKKDDRSRKRDYDRNPPRRDSYRDRYNRRRGRSRSYSRSRSRSWSKERLRERDRDRSRTRSRSRTRSRERDLVKPKYDLDRTDPLENNYTPVSSVPSISSGHYPVPTLSSTITVIAPTHHGNNTTESWSEFHEDQVDHNSYVRPPMPKKRCRDYDEKGFCMRGDMCPFDHGSDPVVVEDVNLPGMLPFPAQPPVVEGPPPPGLPPPPPILTPPPVNLRPPVPPPGPLPPSLPPVTGPPPPLPPLQPSGMDAPPNSATSSVPTVVTTGIHHQPPPAPPSLFTADTYDTDGYNPEAPSITNTSRPMYRHRVHAQRPNLIGLTSGDMDLPPREKPPNKSSMRIVVDSESRKRTIGSGEPGVPTKKTWFDKPNFNRTNSPGFQKKVQFGNENTKLELRKVPPELNNISKLNEHFSRFGTLVNLQVAYNGDPEGALIQFATYEEAKKAISSTEAVLNNRFIKVYWHREGSTQQLQTTSPKVMQPLVQQPILPVVKQSVKERLGPVPSSTIEPAEAQSASSDLPQNVTKLSVKDRLGFVSKPSVSATEKVLSTSTGLTKTVYNPAALKAAQKTLLVSTSAVDNNEAQKKKQEALKLQQDVRKRKQEILEKHIETQKMLISKLEKNKTMKSEDKAEIMKTLEVLTKNITKLKDEVKAASPGRCLPKSIKTKTQMQKELLDTELDLYKKMQAGEEVTELRRKYTELQLEAAKRGILSSGRGRGIHSRGRGAVHGRGRGRGRGRGVPGHAVVDHRPRALEISAFTESDREDLLPHFAQYGEIEDCQIDDSSLHAVITFKTRAEAEAAAVHGARFKGQDLKLAWNKPVTNISAVETEEVEPDEEEFQEESLVDDSLLQDDDEEEEDNESRSWRR
Protein: RE03989p (Q9VGJ8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGLRNSKEKQSNEVKTSKQAPKAQVNPEPPAPPNKPEPEVDHSDLVPKWLNQTQFEELLAADVDQFSKIVGFRVKPAMAPGENYATLMLRISIDVELTDKSTKLVSFMMKVPHDTPQMEQMMSMANFFTSENAAYTEILPKMEELYKAKGLDIKFAPRAFKLDATKEPKVANTVLMHDLGQNGFKNINRLECLNLEQTKFALTRLAQFHAAGATMVQVHGPYPDIFVNGVMGNNKEAIIAFMEGMLASFRTSFMANLDKFKNGEEYREKLEKALAGLTMEFMKLGIVDPNEFNALNHGDCWMNNLLFKMNSSGDLEDMVFVDFQNPKYGSPAMDLLYFIISSVQIDYKLSHFDFFIRHYQEALVKHLGILGFTGRKPSLRELHRTLIKYGGWVLFPTISVLPLVLLDPTQSATFDNFMSDSADGVSFRGSLYANKRCQEYIERILPWLDNRGFLEVSTDPLPPELLAALKPQQPQPENTDQIPDWLNIDDFKEIILSAEPNFEKILSSTSKLATKPGDNFASKLLKVEIEAQLKDNSVKTFSYILKVHSDNDAINFSDFNLFPKEIEVYSTYVPAFERFYKDVGLPVTFSPKSFRLSKDVSKEYLLLENLQPSGFKMVDRMIGMDLEHSKCTLKKLAQWHAASLKYKELNGPYSPKYNNGIFTEQTAPIFKGMFVNTKKSFIEEVSKFDGVDEYLHKMPEILDTYVDRILEDAKINEQAFNVLNHGDAWINNIMFQYESDGRVKETLLLDHQVTKYGNPAQDLYYFIMSSTQLDIKVDQFDYLIRWYHQNMKEHAKLLNYNGFIPSLKELHAILIQHPIFAAGTVLTTLSMCLNKTTDDFTTDSFLGNEENGKSLREAMFSNERYRANIERVMPWINRRGLLDNFANGHSQ
Protein: DNA cross-link repair 1A protein (Beta-lactamase MBLAC2) (EC 3.5.2.6) (SNM1 homolog A) (chSNM1A) (Q5QJC4)
Organism: Gallus gallus (Chicken)
Function: May be required for DNA interstrand cross-link repair.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA repair protein complementing XP-A cells homolog
- Uncharacterized protein.
- Fanconi anemia group M protein
- Fanconi-associated nuclease
- Uncharacterized protein.
- Uncharacterized protein.
- X-ray repair cross-complementing protein 5
- REV3 like, DNA directed polymerase zeta catalytic subunit.
- SLX4 structure-specific endonuclease subunit.
- X-ray repair cross-complementing protein 5
Sequence:
MSEDVLLEEDIWEYKSIRKRKPQSNPDSTSVSMQTVTKGKCRPKRKGSGNRKKSVEKNSTPQKSEQRLRPSEDLDPCKDDSSVYAQESVSSLTEQGSPSTRPVCDGYCPSCQMPFSLLVVQTPRWHVAECLDTPGSVEKECPDGLLCTSTIPSHYKRYSHFLLAASRAGEYLVNSTANTVERKMTCSTAAKSSCFPSPVEDSQAEKPSKNLKNVPNNECTSKIKDSEQRKSLNITSESTSSFADVQKPQQVFQLTQTTDNSCKFEFYDFTSSQESVSEDLCSQKDTSQPSLLQSKADFSDWEISYSPLSTCEESEGEAEEEKEVKTSQNKLLKVQNFEGPESNTEVFKFKKQHCEEINTSSCLYHSEKSASQSHVDSKCSNSPCVDNQQEMLSAESSFPLNCNQEFQQPGLLSPAINTGNKESQDKGACVLDSVYSCLTRTQSLLLTEGGRSPLSQKNKVLRAPSVVLTNTDKMTADATEKGTCQESLQPAVKKEENLDSTGVCFPSPISKTVSSHSLASMNAKSSPAKELKQMDIGVFFGLKPKVKEESKGEACLSEGKQIPSSVAPSGKRPRQQKRKAEGSVEDLEAVEESSNKDGGDANVTSGGQRKWRKRFRESSTTDEGARKKQCPFYKKIPGTGFTVDAFQYGEIEGCTAYFLTHFHSDHYCGLTKNFVFPLYCNKITGNLVKSKLRVKEQYINVLPMDTECIVNGIKVLLLDANHCPGATMILFYLPSGTAILHTGDFRADPSMERYPALIGQKIHTLYLDTTYCSPEYTFPSQQEVIQFAVNTAFEMVTLNPRTLVVCGTYSIGKEKVFLAIAEVLGSKASMSRDKYKTLQCLESAAVNSLITMNWDGTLLHILPMMQINFKGLQDHLNKFSENFDQVLAFKPTGWTYSDSCLSVMDIKPQTRGNITIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGDWRARSLMEKHFRDWMIEGSGHK
Protein: NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2) (Q9DB73)
Organism: Mus musculus (Mouse)
Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cytochrome b5 type B
- Cytochrome b5
- Sulfite oxidase, mitochondrial
- Cytidine monophosphate-N-acetylneuraminic acid hydroxylase
- Dihydroorotate dehydrogenase
- Dihydropyrimidine dehydrogenase [NADP
- Acyl-CoA desaturase 1
- Uridine 5'-monophosphate synthase
Sequence:
MGIQPSPVLLASLGVGLLTLLGLALGTYLVRRSRRPQVTLQDPDEKYLLRLLDKTTVSHNTRRFRFALPTAHHILGLPVGKHVYLSARIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKIGDMVEFRGPSGLLSYAGKGNFNIQPNKKSPPELRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTERDIILREDLEELQAQYPNRFKLWFTLDSPPEDWTYSKGFVTADMIQEHLPAPAEDVLLLLCGPPPMVQLACHPNLDKLGYSQKMRFTY
Protein: Protein Hook homolog 2 (mHK2) (Q7TMK6)
Organism: Mus musculus (Mouse)
Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:25781171}. Cytoplasm {ECO:0000269|PubMed:17140400}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:28003339}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q96ED9}. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (By similarity). Often found in close association with microtubules (By similarity). Localizes to the manchette in elongating spermatids (PubMed:28003339). {ECO:0000250|UniProtKB:Q96ED9, ECO:0000269|PubMed:28003339}.
Interaction partners:
- AKT-interacting protein
- FHF complex subunit HOOK-interacting protein 1B
- Protein Hook homolog 3
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Protein Hook homolog 1
- Vacuolar protein sorting-associated protein 16 homolog
- Vam6/Vps39-like protein
- Cytoplasmic dynein 1 light intermediate chain 1
- Syntaxin-17
Sequence:
MSVDKAELCGSLLTWLQTFQVSPPCASPQDLSSGLAIAHVLNQIDPSWFNNEWLQGISEDSSPSWRLKVRKLEKILQSLVEYSKNVLGHPVSDQHLPDVSLIGEFSNPAELGKLLQLVLGCAISCEKKQEYIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPENYGNFDTQSRRYYFLSEEVEEGDHLQQHYLDLERQLLLLSEEKQNLAQENAALRERVGRSEVESAPGLTAKKLLLLQSQLEQLQEENFRLESSREDDRLRCLELEREVAELQQRNQALTSLSQEAQALKDEMDELRQSSERARQLEATLNSCRRRLGELQELRRQVRQLEERNAGHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGQWQEEAMKAEKWLFECRNLEEKCDLVTKEKERLLTERDSLREANEELRCAQLQPRGLAQADLSLDPTPSGLENLAAEILPAELRETLVRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLEAQQRLNQQQLSELRAQVEELQKALQEQGGKTEDPTLLKRKLEDHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQDSLQKKDADLRAMEERYRRYVDKARTVIQTLEPKQRPPTVVSPEFHTLRSQLWERNLRIRQMEMDYEKSRRRQEQEEKLLISAWYSMGMALEHRAGEEHAPAHAQSFLAQQRLATNARRGPLGRQALSLRPTDKH
Protein: UPF0153 protein YeiW (P0AFT8)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YphG
- Uncharacterized protein YphH
- Uncharacterized protein YjiS
- Uncharacterized protein YijF
- Inner membrane protein YjgN
Sequence:
MECRPGCGACCTAPSISSPIPGMPDGKPANTPCIQLDEQQRCKIFTSPLRPKVCAGLQASAEMCGNSRQQAMTWLIDLEMLTAP
Protein: Prefoldin subunit 5 (Gene involved in microtubule biogenesis 5) (P57742)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Together with other chaperonins, contribute to the regulation of gene expression by modulating the spliceosome function on pre-mRNA splicing post-transcriptionally by acting as a co-chaperone of Hsp90 to control levels of LSM8 (By similarity). Required for the biogenesis of tubulins and for subsequent microtubules (MTs) organization and dynamicity. Necessary for tolerance to NaCl salt stress. Involved in the process leading to microtubules dissociation in response to gibberellic acid (GA) probably due to the DELLA proteins-mediated translocation of the prefoldin co-chaperone complex from the cytoplasm to the nucleus. Prevents cold acclimation (e.g. 7 days at 4 degrees Celsius) in a DELLA proteins-dependent manner by promoting nuclear proteasome-mediated HY5 degradation, thus modulating the expression of several genes and reducing anthocyanin biosynthesis, but seems not involved in constitutive freezing tolerance. Contributes to the GA-dependent regulation of PIN2 trafficking at the plasma membrane, thus influencing auxin flux.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23583555}. Nucleus {ECO:0000269|PubMed:23583555}. Note=In the presence of gibberellic acid (GA) and at room temperature, the prefoldin complex stays in the cytoplasm and is functional (PubMed:23583555). But in the absence of GA or in response to cold, the prefoldin complex is localized to the nucleus in the presence of DELLA proteins, which severely compromises alpha/beta-tubulin heterodimer availability, thus affecting microtubules (MTs) organization (PubMed:23583555). This changing subcellular localization follows a daily rhythm coordinated oscillation (PubMed:23583555). Interacts with LSM8, a specific subunit of the LSM2-8 complex, which is core components of the spliceosome (PubMed:32396196). {ECO:0000269|PubMed:23583555, ECO:0000269|PubMed:32396196}.
Interaction partners:
- Prefoldin subunit 3
- Prefoldin subunit 6
- Prefoldin subunit 2
- Prefoldin subunit 4
- Prefoldin subunit 1
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit beta
- At1g49245
- Prefoldin chaperone subunit family protein
Sequence:
MASSSSRGEMEKMGIDQLKALKEQADLEVNLLQDSLNNIRTATVRLDAAAAALNDLSLRPQGKKMLVPLTASLYVPGTLDEADKVLVDIGTGYFIEKTMDDGKDYCQRKINLLKSNFDQLFEVAAKKKSVADEAGMVLQAKVKQLTAATTS
Protein: Thiamine pyrophosphokinase 1 (AtTPK1) (EC 2.7.6.2) (Thiamine kinase 1) (B9DGU7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP). TPP is an active cofactor for enzymes involved in glycolysis and energy production. Plant leaves require high levels of TPP for photosynthesis and carbohydrate metabolism.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17611796}.
Interaction partners:
- Bifunctional TH2 protein, mitochondrial
- Small ribosomal subunit biogenesis GTPase RsgA 1, mitochondrial
- Thiamine biosynthetic bifunctional enzyme TH1
- Phosphomethylpyrimidine synthase, chloroplastic
- Adenylate kinase 4
- Adenylate kinase 1, chloroplastic
- Adenylate kinase 5, chloroplastic
- Probable adenylate kinase 6, chloroplastic
- Probable adenylate kinase 7, mitochondrial
- Adenylate kinase 2, chloroplastic
Sequence:
MSAMDVMIHSSSFLLPCDETSTGTRYALVVLNQSLPRFTPLLWEHAKLRLCADGGANRIYDELPLFFPNEDALAIRNRYKPDVIKGDMDSIRRDVLDFYINLGTKVIDESHDQDTTDLDKCILYIRHSTLNQETSGLQILATGALGGRFDHEAGNLNVLYRYPDTRIVLLSDDCLIQLLPKTHRHEIHIQSSLEGPHCGLIPIGTPSAKTTTSGLQWDLSNTEMRFGGLISTSNLVKEEKITVESDSDLLWTISIKKTGLSIQDHTP
Protein: Brain mitochondrial carrier protein 1 (BMCP-1) (Mitochondrial uncoupling protein 5) (UCP 5) (Solute carrier family 25 member 14) (O95258)
Organism: Homo sapiens (Human)
Function: Participates in the mitochondrial proton leak measured in brain mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:20600837}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGIFPGIILIFLRVKFATAAVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRLQI
Protein: BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) (M0R2K3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADDGSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNALNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTE