wanglab/gogpt-training-data huggingface dataset:
Protein: Cytochrome c-type biogenesis protein CcmE homolog, mitochondrial (Cytochrome c maturation protein E homolog) (AtCCME) (Heme chaperone CcmE homolog) (Q96326)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Heme-binding chaperone that may be involved in cytochrome c maturation in mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11069919}; Single-pass membrane protein {ECO:0000255}. Mitochondrion intermembrane space {ECO:0000269|PubMed:11069919}. Note=According to some authors, CCME is a peripheral mitochondrion inner membrane protein with the hydrophilic domain oriented toward the mitochondrion intermembrane space (PubMed:11069919). {ECO:0000269|PubMed:11069919}.
Interaction partners:
- Cytochrome c biogenesis protein CcsA
- Autophagy-related protein 13a
- Autophagy-related protein 11
- Cytochrome c-type biogenesis CcmH-like mitochondrial protein
- Autophagy-related protein 101
- Autophagy-related protein 9
- Ubiquitin-like-conjugating enzyme ATG10
- Ubiquitin-like modifier-activating enzyme atg7
- Autophagy-related protein 3
- Autophagy-related protein 16
Sequence:
MAARLLFRRSSQILRSIQRNPQISSSFESPPCPIFHSLTTASPDPSRLSSLTFLRSLSIARRGPTRPKKIDIGAKARQMQNRRLWTYALTFSCIAGFVVIVLNQFQDQLVFYLTPSDAMEKFAENPTKNKFRLGGLVLEGSVAQPAASQEMEFVITDLITDILVRYKGSLPDLFREGHSVVVEGFIKPYTDEVRKEVSTKPISKKARNLDCFFSATEVLAKHDEKYMPQEVAAAIEKNKKIIEAAATEQAAEVAAS
Protein: SCAN domain-containing protein 1 (Q9Z0V9)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
Interaction partners:
Sequence:
MAAPQPSQDPQSPAAPPEQQEGAGDCAAPSPDSGSSPAPELPGAPAALNTAPYADAVLRPGASRPGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLQAILPEAARARRLRRRADVRITG
Protein: Epidermal growth factor receptor pathway substrate 15 (A7BFV9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLNKQEFFIALRLVACAQNGLEVSLSSLNLAVPPPRFHDSSSPLLTSGTSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSTLLAHIWALCDTKNCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDRSSLQKNTIGSSPVADFSAIKELDTLNNEIIDLQREKNNVEQDLKEKEDTVRQRTTEAQDLQDEVQRESLNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAEITSQESQISTYEEELSKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRLAMKDLETDNNQSNWCSSPQSILVNGAADYCSLSTSSSETANLNEHAEGQNNLESEPIHPESSVRSSPEIAPSDVTDESEVVTAADIEKVSPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFATSSTDPFSASSNSSNTSVETWKHNDPFAPGGTVVAATDSATDPFASVFGNESFGDGFADFSTLSKVSNEDPFNPTISSSASSVVIPKPVLEETPSKSEDVPPALPPKTGTPTRPCPPPPGKRPINKLDSSDPFKLNDPFQPFPGNDSPKEKDPDMFCDPFTSSSTTANKEAEPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
Protein: Transmembrane GTPase fzo1 (EC 3.6.5.-) (Q9USY7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondrial morphology, which is balanced between fusion and fission (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Dynamin-related protein dnm1
- Mitochondrial fusion and transport protein ugo1
- Mitochondrial fission 1 protein
- Non-selective voltage-gated ion channel
- OPA3-like protein
- Mitochondrial distribution and morphology protein 10
- Mitochondrial import inner membrane translocase subunit tim23
- Mitochondrial distribution and morphology protein 12
- Probable mitochondrial import receptor subunit tom70
- Mitochondrial import receptor subunit tom20
Sequence:
MEKSARQLSVAEQNGESGRLNNGYTSNNIQQYKDETNRHQFEYNQNRNQLLRSIHIIQNLLNELDNYVDRSDCLFHSVWRTDKEKSKFSGNYYPFSPSKMNVITIDLSLRSSSTADEKLISQLGEEAHESLLKVHIEKANKHLFSLFSRVEDTSSKILITGDLNAGKSTLCNALVHKDILPEDQQPCTEVFCEVHDAELNDGKDCVHAIPHGLTYSHTDSSTYKVFPIEDLKRLVYETENWSMLIVYVNDGRPAHESLLHNGITDIALIDAPGLNTDSMKTTSVFACQEEIDVVVFVVNAENHFTLSATDFLRNASTEKSHIFIIVNKFDNIRDKERCKRLILEQIHTLSPGTFADAKDLVHFVSCRVARDPNNREDALYSSFFQMENSLRSFILENRSKSKLAPVRRYLSGLVGDILNICEYNIKLIDFDINHLQQRLTDLSPKFRKVKHEQQFTYQKNESLVEATVQSISQHTHSELEDAIDSLGSFASVKYSGFFFAYQYAISVRDAMQQYLEEKLLESEDYARKRTEEAVLCIQKDVKDNFDSAVLPVFHANQMFIKKHRLQLQKHFRFELGLLDFIDLDLTERLGTWSASLSTILLVLGKTTPSFTTLGAFTGNLGYPIFKYFQNNSLQHLLVPVLGLASICVFGYVIYDIPRALPLKVAEKIKKSLRETDFCHNASIWIGTESRKVLNIPLNDLRRMFHQQWDKQRETISVAENDLRICQKARKFFGEIESRTREAKKKIMMVQLEGCDINY
Protein: Scarecrow-like protein 32 (AtSCL32) (GRAS family protein 18) (AtGRAS-18) (Q9SN22)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in plant development.
Subcellular location: Nucleus {ECO:0000269|PubMed:18500650}.
Interaction partners:
- DNA repair endonuclease UVH1
- Protein PAT1 homolog
- Thiohydroximate-O-sulfate sulfur/sulfate-lyase
- Thiohydroximate-O-sulfate sulfur/sulfate-lyase
Sequence:
MTKTRILNPTRFPSPKPLRGCGDANFMEQLLLHCATAIDSNDAALTHQILWVLNNIAPPDGDSTQRLTSAFLRALLSRAVSKTPTLSSTISFLPQADELHRFSVVELAAFVDLTPWHRFGFIAANAAILTAVEGYSTVHIVDLSLTHCMQIPTLIDAMASRLNKPPPLLKLTVVSSSDHFPPFINISYEELGSKLVNFATTRNITMEFTIVPSTYSDGFSSLLQQLRIYPSSFNEALVVNCHMMLRYIPEEPLTSSSSSLRTVFLKQLRSLNPRIVTLIEEDVDLTSENLVNRLKSAFNYFWIPFDTTDTFMSEQRRWYEAEISWKIENVVAKEGAERVERTETKRRWIERMREAEFGGVRVKEDAVADVKAMLEEHAVGWGMKKEDDDESLVLTWKGHSVVFATVWVPI
Protein: Somatotropin (Growth hormone) (Q07221)
Organism: Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha)
Function: Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MGQVFLLMPVLLVSCFLSQGAAIENQRLFNIAVSRVQHLHLLAQKMFNDFDGTLLPDERRQLNKIFLLDFCNSDSIVSPVDKHETQKSSVLKLLHISFRLIESWEYPSQTLIISNSLMVRNANQISEKLSDLKVGINLLITGSQDAYMSLDDNDSQQLPPYGNYYQNLGGDGNVRRNYELLACFKKDMHKVETYLTVAKCRKSLEANCTL
Protein: F-actin-capping protein subunit alpha-3 (CapZ alpha-3) (Germ cell-specific protein 3) (P70190)
Organism: Mus musculus (Mouse)
Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0PFK5}.
Interaction partners:
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha-2
- F-actin-capping protein subunit alpha
- Dynactin subunit 2
- Actin-related protein 10
- Dynactin subunit 4
- F-actin-capping protein subunit alpha-1
- Kinesin-like protein KIF2B
- Dynactin subunit 1
- Protein S100-B
Sequence:
MSLSVLSRKEKEKVIHRLLVQAPPGEFVNAFDDLCLLIRDEKLMHHQGECAGHQHCQKYCVPLCIDGNPVLLSHHNVMGDFRFFDYQSKLSFRFDLLQNQLRDIQSHGIIRNETEYLRSVVMCALKLYVNDHYPNGNCNVLRKTVKSKEFLIACIEDHSYDNGECWNGLWKSKWIFQVNPFLTQVTGRIFVQAHFFRCVNLHIEVSKDLKESLEVVNQAQLALSFARLVEEQENKFQAAVIEELQELSNEALRKILRRDLPVTRTLIDWQRILSDLNLVMYPKLGYVIYSRSVLCNWII
Protein: Troponin I 2 (CeTNI-2) (TnI 2) (Uncoordinated protein 27) (Q9GYF1)
Organism: Caenorhabditis elegans
Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.
Interaction partners:
- Troponin T
- Troponin T
- Tropomyosin isoforms a/b/d/f
- EF-hand domain-containing protein
- Troponin T, skeletal muscle
- TropoNin T
- Myosin, essential light chain
- Myosin regulatory light chain 2
- Myosin regulatory light chain 1
- Myosin-4
Sequence:
MSEEAGEDAQRKAAEREAKKAEVRKRLEEAGNKKKAKKGFLTPERKKKLRKLLMVKAAEDLKRQQLLKEQERQKALADRTISLPNVDSIDDKGQLEKIYNDLWARLTQLEEEKYDINYVVSQTEAEINSLTIEVNDLRGKFVKPSLKKVSKYDNKFKKSGESKAGTKEDFRANLKIVKKDVMEAIVNVKKKDDKPDWSKKNKDAKAEDSAPAAVAPEAEPVAEEAEAEPEAEEEEGEEEEEE
Protein: Cytochrome P-450 monooxygenase DoxA (EC 1.14.13.181) (13-deoxycarminomycin C-13 hydroxylase) (13-deoxydaunorubicin C-13 hydroxylase) (13-dihydrocarminomycin C-13 hydroxylase) (13-dihydrodaunorubicin C-13 hydroxylase) (Q9ZAU3)
Organism: Streptomyces peucetius
Function: Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In vivo, DoxA catalyzes the C-13 hydroxylation of 13-deoxycarminomycin and 13-deoxydaunorubicin to yield 13-dihydrocarminomycin and 13-dihydrodaunorubicin, respectively, as well as the oxidation of these 13-dihydro-anthracyclines to their respective 13-keto forms, carminomycin and daunorubicin. In vitro, it also catalyzes the C-14 hydroxylation of daunorubicin to form doxorubicin (adriamycin), although this strain is not a doxorubicin producer. It can only use NADP. DoxA acts jointly with DnrV.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MAVDPFACPMMTMQRKPEVHDAFREAGPVVEVNAPAGGPAWVITDDALAREVLADPRFVKDPDLAPAAWRGVDDGLDIPVPELRPFTLIAVDGEAHRRLRRIHAPAFNPRRLAERTDRIAAIAGRLLTELADASGRSGKPAELIGGFAYHFPLLVICELLGVPVTDPAMAREAVSVLKALGLGGPQSGGGDGTDPAGGVPDTSALESLLLEAVHSARRNDTPTMTRVLYERAQAEFGSVSDDQLVYMITGLIFAGHDTTGSFLGFLLAEVLAGRLAADADEDAVSRFVEEALRYHPPVPYTLWRFAATEVTIGGVRLPRGAPVLVDIEGTNTDGRHHDAPHAFHPDRPSWRRLTFGDGPHYCIGEQLAQLESRTMIGVLRSRFPEARLAVPYDELRWCRKGAQTARLTELPVWLR
Protein: Ribonuclease J (RNase J) (EC 3.1.-.-) (Protein EMBRYO DEFECTIVE 2746) (Q84W56)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required during embryogenesis, especially in initiating and maintaining the organization of shoot apical meristems (SAMs), cotyledons, and hypocotyls. Involved in auxin-mediated pathways during embryogenesis. RNase that has both endonuclease and 5'-3' exonuclease activities. Involved in RNA surveillance to prevent overaccumulation of antisense RNA. Probably involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity).
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:22033332}.
Interaction partners:
- Flowering time control protein FY
- Cleavage stimulating factor 64
- Cleavage and polyadenylation specificity factor subunit 2
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
- Cleavage stimulation factor subunit 77
- 30-kDa cleavage and polyadenylation specificity factor 30
- Zinc finger CCCH domain-containing protein 65
- FIP1[III]-like protein
- FIP1[V]-like protein
- Symplekin
Sequence:
MMKPASLQGFSSHASSSIYSDVRRPATTPSKMAAFSALSLCPYTFTFRQSSRIKSTVSCSVTSAPASGTSSSSKTPRRRSGRLEGVGKSMEDSVKRKMEQFYEGTDGPPLRILPIGGLGEIGMNCMLVGNYDRYILIDAGIMFPDYDEPGIQKIMPDTGFIRRWKHKIEAVVITHGHEDHIGALPWVIPALDPNTPIFASSFTMELIKKRLKEHGIFVQSRLKTFSTRRRFMAGPFEIEPITVTHSIPDCSGLFLRCADGNILHTGDWKIDEAPLDGKVFDREALEELSKEGVTLMMSDSTNVLSPGRTISEKVVADALVRNVMAAKGRVITTQFASNIHRLGSIKAAADITGRKLVFVGMSLRTYLEAAWRDGKAPIDPSSLIKVEDIEAYAPKDLLIVTTGSQAEPRAALNLASYGSSHAFKLTKEDIILYSAKVIPGNESRVMKMMNRIADIGPNIIMGKNEMLHTSGHAYRGELEEVLKIVKPQHFLPIHGELLFLKEHELLGKSTGIRHTTVIKNGEMLGVSHLRNRRVLSNGFSSLGRENLQLMYSDGDKAFGTSSELCIDERLRISSDGIIVLSMEIMRPGVSENTLKGKIRITTRCMWLDKGRLLDALHKAAHAALSSCPVTCPLSHMERTVSEVLRKIVRKYSGKRPEVIAIATENPMAVRADEVSARLSGDPSVGSGVAALRKVVEGNDKRSRAKKAPSQEASPKEVDRTLEDDIIDSARLLAEEETAASTYTEEVDTPVGSSSEESDDFWKSFINPSSSPSPSETENMNKVADTEPKAEGKENSRDDDELADASDSETKSSPKRVRKNKWKPEEIKKVIRMRGELHSRFQVVKGRMALWEEISSNLSAEGINRSPGQCKSLWASLIQKYEESKADERSKTSWPHFEDMNNILSELGTPAS
Protein: F(1)-ATPase inhibitor STF1, mitochondrial (9 kDa ATPase inhibitor complex-stabilizing factor) (9K) (Stabilizing factor 1) (P01098)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: This is 1 of 2 proteins that can stabilize the ATPase-inhibitor complex, which normally dissociates when externally added ATP has been consumed.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12167646, ECO:0000269|PubMed:6200468}.
Interaction partners:
- F
- ATPase-stabilizing factor 15 kDa protein
Sequence:
MLNRCISRNTRLPVNLRIASRFYSDGPLGGAGPGNPQDIFIKRERAKEDYYARQQEREQLAHVKEQLKEHKKKLENLENKINNLSK
Protein: Glucosylceramidase (EC 3.2.1.45) (B2RYC9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Lysosome membrane {ECO:0000256|ARBA:ARBA00004207}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004207}; Lumenal side {ECO:0000256|ARBA:ARBA00004207}.
Interaction partners:
- Prosaposin
- Non-lysosomal glucosylceramidase
- Ceramide glucosyltransferase
- Sphingomyelin phosphodiesterase
- Acid ceramidase
- Galactocerebrosidase
- Beta-galactosidase
- Ceramide kinase
- Ceramide synthase 3
- Phosphatidylcholine:ceramide cholinephosphotransferase 2
Sequence:
MAARFIGLFLFQAISWAYGAQPCIPKSFGYSSVVCVCNATYCDSLDPLTLPALGTFSRYESTRSGRRMELSTGSIQANRTGTGLLLTLQPEEKFQKVKGFGGAMTDATALNILALSPPAQKLLLKSYFSSEGIEYNIIRVPMASCDFSIRIYTYADTPNDFQLSNFSLPEEDTKLKIPLIHRALKMSPRPISLFASPWTSPTWLKTNGAVNGKGSLKGHPGDIYHEAWANYFVKFLDAYATHNIKFWAVTAENEPSAGLFTGYPFQCLGFTAEHQRDFISHDLGPALANSSHDVKLLILDDQRLLLPRWAQVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNMMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASEKTDLETVALIRPDGSAVVVVLNRSSKDVPLTISDPALGFMETISPGYSIHTYLWRRQ
Protein: Glucosidase II beta subunit-like (Q382R9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Glycosyl hydrolase-like protein
- Glucosidase II subunit alpha
Sequence:
MRERNASVSRHPDGKHSNERRNPEKDFSIPSRESECGALFWIAAAVVVAALSCTSVLVLTSTKPSSERRGERREDAVAHKGAQLAPPPPQGVTYYEGKASPTQKEQRAGEWSCYTMEEYSLKFIGGLREMRHSSLRSKNQSGPQYFFRCGIRIIDTETEQNHTKVKQCAAAAHGETSFPTLRVYLSSGMEERLHKKQKKNFAAQHILLERLNDDYCDCLDGTDELTTNACSMSGVVAPLARKRWRQFLTSNEHVRLYEDEEMMSKEHAERLLTRVGGRVLPFRCKNDQGVLLTPSMMNDGIVDCCDGSDEVDQVRRDEWATRVGQLEPLLDKSSGPESNLRVGDHNTVAQMLMRTGQNGLMTCDRMKRERLREAKALYTLVERGHATWKERVADGWEKYGSEFLDRRVEVQRKFNDTAALFTEVRTRIKKRMQELGVQTPLAPGVPHQEVQRAEELAATLGRLNMQLRHMQLVLDLGVLGDSFEYSVIASRSYSVAQQRLWNPIQGRSTHTQQQLYDEGQYDGNSPVGTSPENLPLHVDNVSFTGFSVDPFAHINGWVRVMDKGKRARLYGDENSLNDNATGNSTSADIDSEPIVIGFWVPLPASPLTSQMSSINPPTGDGALWRRLFSTKLAPSKGGFDKILSERQIGKKRLRELGDKQPHGAPSEPVVHVFSGGIPCQDNGAAEPMYSHGWLVFVCADTDGVLEWHRNGKCEHQIVFGTTSACSVRVMEEAATRLQHAEASVRESINPRREVGE
Protein: Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Q02863)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Ubiquitin-ribosomal protein eS31 fusion protein
- SAGA complex subunit SGF29
- SAGA complex subunit SUS1
- SAGA complex subunit SPT3
- SAGA complex subunit SGF73
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
Sequence:
MSWIKNVTESPTSLIKKVSCGLIIAASLYAIAPSLSALVFGDSKQSIGKYTTVGLINRGNDCFITSSLQGLAGIPRFVEYLKRIRTVLLELETKLSNNAKGDNPTVDNTTRHSRLENSSNSLAPLHESLTSLILDLISVKDRKTSISPKIVINTLESIFKSKISSKQNDAHEFTLILLQTLQEERSKLIDYSKQICNLNIPKFPFEGETSKFLVCLKCKGLSEPSYKQTFIRELSVPQQTSENLSNILAHDETEIIDDYSCLICQIRAILNHEEYRNFKDCTPDEILMLDRLKNYATKAPINENLPFEVEQYVKRYSKGNLQVSNIKGKVIKKDVVVQLPDILIVHLSRSTFNGITYSRNPCNVKFGERITLSEYTLAESGTITENRQVKYNLKSVVKHTGSHSSGHYMCYRRKTEIRFGKEDESSFRRAPVVNNEVNKNREQNVAHNDYKKSRYKKVKNALRYPYWQISDTAIKESTASTVLNEQKYAYMLYYERVNK
Protein: Cell surface hyaluronidase CEMIP2 (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2) (Q9UHN6)
Organism: Homo sapiens (Human)
Function: Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments. Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5FWI3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5FWI3}.
Interaction partners:
- Leucine-rich repeat transmembrane neuronal protein 2
Sequence:
MYATDSRGHSPAFLQPQNGNSRHPSGYVPGKVVPLRPPPPPKSQASAKFTSIRREDRATFAFSPEEQQAQRESQKQKRHKNTFICFAITSFSFFIALAIILGISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYILIQDGGALHIGAEKCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFGSYTFEKDFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQERLGSELIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWIEGVSLSGFRVEVVDGVKLNLLDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCSECSHFQVKVKETPQFLHMGEIIDGVDMRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMIMKNFTSVHLSYVELKHMGQQQMGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSNFKAGLFIDKGVKTTNSSAADPREYLCLDNSARFRPHQDANPEKPRVAALIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTRSTFKKYVPTPDRYSSAIGFLMKNSWQITPRNNISLVKFGPHVSLNVFFGKPGPWFEDCEMDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCVNVSKWNAVICSGTYAQVYVQTWSTQNLSMTITRDEYPSNPMVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYLQRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQVVFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLTEKTVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGSTIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQASKAH
Protein: Bidirectional sugar transporter SWEET9 (AtSWEET9) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 9) (Q9ZV02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates both low-affinity uptake and efflux of sugar across the plasma membrane (By similarity). Nectary-specific sugar transporter required for nectar production by mediating the secretion of sucrose from the nectary parenchyma to the extracellular space.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24670640}; Multi-pass membrane protein {ECO:0000269|PubMed:24670640}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:24670640}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:24670640}.
Interaction partners:
- Germin-like protein subfamily T member 3
- AIR1A-like protein
- Beta-fructofuranosidase, insoluble isoenzyme CWINV4
- Protein DETOXIFICATION 32
- MYB-like DNA-binding domain protein
- UDP-galactose/UDP-glucose transporter 5B
- Protein CRABS CLAW
Sequence:
MFLKVHEIAFLFGLLGNIVSFGVFLSPVPTFYGIYKKKSSKGFQSIPYICALASATLLLYYGIMKTHAYLIISINTFGCFIEISYLFLYILYAPREAKISTLKLIVICNIGGLGLLILLVNLLVPKQHRVSTVGWVCAAYSLAVFASPLSVMRKVIKTKSVEYMPFLLSLSLTLNAVMWFFYGLLIKDKFIAMPNILGFLFGVAQMILYMMYQGSTKTDLPTENQLANKTDVNEVPIVAVELPDVGSDNVEGSVRPMK
Protein: Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (Protein LLRep3) (Ribosomal protein S4) (P27685)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Interaction partners:
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein eL19
- Small ribosomal subunit protein eS25
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein eL36
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein eS19
Sequence:
MADTTTAAQADQKPTRAFGAGRPQRGAGGAPQRGGPRPQRGGQGETKSWTPVTKLGRLVALGLVENIHEIYLFSLPIKEYQIIDKFLNLKDEVMKIVPVQKQTRAGQRTRFKAFVVVGDHNGHVGLGVKCAKEVATAISGAIVAAKLSVIPVRRGYWGNKLGAPHTVPTKVTGKCGSVAVRLVPAPRGTGIVAARVPKKLLQYAGVDDVYTSSRGKTRTMGNFVMATFFAITKTFAYLTPDLWREVKLIKTPYQEHSAKLSEKQQ
Protein: RE04093p (Q8IGY8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVQALDYDCEAQGQDIPQAIQLLGEMNSNVKQVTDLVEGMLQRVKRGELTTEYGLSFLEVKYHMLLDYLINLTYVVLRKCSGETIEGDPSIERLIEIRTVLEKIRPIDHKLRYQIDKLVKTATTGVSSSTDPILYKPNPDEMMSSAGGAGRDEDDGEDDSDEEDEDDDEEDEDEAGAAKMPRKAATAGKSGVYVPPRIKPVYYDGDERDADKEKKALDRAKKRAITSSMLQDLKEEYLDAPTEISSGSRAQQMLSQAQKEKQEYEETYLMRLPVTKAEKHRQRKLTTLGTLGDEILGEISRESALRGDGSKKRKLAKKGKGKKRGGKKRKFH
Protein: GH26094p (Q9VIL4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH20441p
- GH07855p
- GH06435p
- Cytosol aminopeptidase
- GH14622p
- GH27720p
- Uncharacterized protein, isoform E
- GH03227p
- AT18965p
- Dicarboxylate carrier 2
Sequence:
MFRNLSMLRNQLALHRVRVARSTLHSKMSTGLTCLTIDRPRNIDGVTVIDININEMAKTDVEFNRNFVNSLTLMDHTPFKEVTNIVDADAVESPPAENPISGDTVEILPTGAPSSVVGVDGNPIVPIEIDGWNQDEEDPTVQKNVQDVDIGNDDEYKAEMELRVPEVREGRTEYKGIKVTLPESANQDVGTYRFRRDPKDLEEVGDDTRLVRYDK
Protein: Cysteine--tRNA ligase CPS1, chloroplastic/mitochondrial (EC 6.1.1.16) (Chloroplast synthesis protein 1) (Cysteinyl-tRNA synthetase) (A0A1D6LAG9)
Organism: Zea mays (Maize)
Function: Nuclear genome-encoded factor required for normal assembly of chloroplast polysomes.
Subcellular location: Plastid, chloroplast {ECO:0000305|PubMed:12271069}. Mitochondrion {ECO:0000255}. Note=The cps1 mutant phenotype resembling other non-photosynthetic mutants, CPS1 may function solely in chloroplasts. {ECO:0000305|PubMed:25725436}.
Interaction partners:
- cysteine--tRNA ligase
- cysteine--tRNA ligase
- Tyrosine--tRNA ligase
- Ribonuclease III family protein
- Tryptophan--tRNA ligase, cytoplasmic
- NifS-like protein
- tryptophan--tRNA ligase
- Elongation factor 1-gamma 3
- Putative elongation factor 1-gamma 2
- Elongation factor gamma1
Sequence:
MAAAVVVRRAAGLIPLLSSRFGARMPLHRALSQIPPPRFCRLLSQQTKPFSASASNGAATDRTRELRLYNTKSRKKEQFRPRIPGREVGMYVCGVTPYDDSHIGHARAYVAFDVLYRYLRYLDYEVRYVRNFTDIDDKIIARANQLGEDPFSLSKRFSDDFLSDMANLQCLPPSVEPRVSDHVDEIINMIKQILDNRCAYVVGGDVYFSVDNFPEYGELSGRKLDDNRAGERVAVDERKRNPADFALWKAAKDGEPWWDSPWGPGRPGWHIECSAMSAHYLGHSFDIHGGGEDLIFPHHENEIAQSRAACCDSTINYWIHNGFVNVNSQKMSKSLGNFVTIRKVIEMYHPLALRMFLLGTHYRSPINYTIEQLNVASDRLYYTYQTLRDCEEICQHQQSNTGNPLPANTLNYIQKLHDEFETSMSDDLHTSVALAAMSEPLKVMNDLLHTRKGKKQDKRLESLSALEEKIRVVLSVLGLLPSSYHEALQQLRDKALRRASITEELVVQKIEERTAARKAKQYEKSDEIRKELAAVGIALMDGPDGTTWRPSLPLPEEEAVLAKT
Protein: Utp4p (A0A1D8PJD3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- 13 kDa ribonucleoprotein-associated protein
- U3 small nucleolar ribonucleoprotein protein IMP4
- rRNA-processing protein
- Nucleolar protein 56
- rRNA-processing protein
- Nan1p
- SnoRNA-binding rRNA-processing protein
- Ribosome biosynthesis protein
- Nucleolar protein 58
- Utp20p
Sequence:
MDIHRCRFVDYTPHTITSLAFSHKSSLTSLPTADVRLAVGRSNGDIEIWNPRHNWTHELTLPGSKGRSIEGLCWSYNEQDPLEPPRLFSIGGSTYITEWDLSTGRPLINYDCNAGIIWCIDINPQNDRLTVGCDDGSVVIVDISGGRGSLEYDLICQRQDARVLSVKWANNEHVIGGCADGRIRSWSSEGETKGRLVATMKVDKAKTESTLVWSLTVLPNKKQFVSGDSTGSIKIWDLTRFTLLQTFKIHDADVLCLVHDVKEEKIFSAGVDRKIHQFDLLNSKNSSKWTHSFNRLLHSNDVRSLAIFENKNYNLLVSGGVERAIVVQNIETFYDGKYKKLLINQQQSNILIVPDSKLVILWQDQTIKIWKVLPDGKHVLMSKLTLSADENITSVDFKDNLLVVAKMTSVRFFELTEISDNKFKIQKIRDDKFDSLVEGAKIVKFIDANKVLILTPDEELYTFDIDSDEGKIELNGEIELLESTQQQQQQQQRKNQHLLRINNLVLTPNKKQIIISRFNGSIEVYPIVNTETEAYVLTKLSSYPHLIECVNDEKLVVINEENKIFEFFINDKDGQLLTPWSKRNSEFLPRQFISLQDKPEGMFIQQKQEKLWIYGSTWLSFFDLSMNIPISKIYKNTSTSKKRNHDGLSMNEEIGELEDETEEIIEASLKQSEIDRLRHQIQTEDKDNQNNVDKTKKPFWITEKYRPIMKVANFGGNDDIIVVERPYSSLQTGPAFDLPKIKV