wanglab/gogpt-training-data huggingface dataset:
Protein: Mitochondrial carrier protein, putative (Q389T3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- ATP synthase alpha chain
- Reiske iron-sulfur protein, mitochondrial
Sequence:
MLGRFDFLGKCRLYFVVVSRLFSFEGDYVAYRLFFVYFVFFTLSFLFVWSRRVVVEFSAFYFFCCFLGGVISGLAHTSMTPVDLVKCGVQVGLYNSMTDGFRSLWRNCGGCWFRSISVFTRGWVPTFFGYSSQGGLKFLLYELLKFWFCSRLEGSAASPMVLSYVSKLGIFVVSSGVAEIFADVALAPWEAVKIIIQTSNVAHTELSYFFPLVYSSEGIYGFYKGLPALWCRQVPYTVVKFLSFEVIVRLAYRYLLTSPSDPAPKYVQLLVSVISGVLAGFLCAAVSHPADTVVSKLNQRVEGSPAADKRKVVQIVRELGWSGLWKGVELRMMMTGALTALQWLLYDSFKVSVGLSATGGNGVRISNHVDSDGRPPGDNK
Protein: PH-sensitive chloride channel 1, isoform C (RE33441p) (Q9VUV3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGCVFEAAKEQPHKPRSRQLRRNQCRGKAEKAAAGTRGKVAVRGNNDKPAEDIKIKDNYQQNHKTQTETQTEVAAVVAIATDAGAETETETEAEAQKEPATGPEHLKAAAQVLLTIRQARQENNKHSSSQVAETHKDEGEDALARQGSIVDTAAGRIGIDIAATTIQVAERHEDGQHWQQHNVRRRRRQPDPAAHPASITKLSAISLHFHALAALAKTLQKHEDLSPVQDRQPLAYRAWQEHPYAETQMPATMSAAIIANVGATAAATSAAAFQYLGQHYKHYSQSISFYAASSVLLMLCYLTTASTAAATQSETGALDKHPIHGIDWSKFDESSSDKEILDLLLEKKRYDKRLLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRLQYGNKSHYDFLNALHHHDSIWTPDTYFIMHGDFKDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKNDEDTLRKSPSLTTLNAYLIKNQTTACDQNSWRGKSLGSQLPVIECQSLHLLILCISQRNYNREMFCSLVIVVFLMVNWYLLCTTYKNGKFHTIILGFFVQNGPSQFSTPFFGLALK
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-B (Q9M9R9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 2
- NADH dehydrogenase 1 alpha subcomplex subunit 1
- At1g67350
- NADH dehydrogenase 1 beta subcomplex subunit 7
- Excitatory amino acid transporter
- At4g16450
- NADH dehydrogenase 1 beta subcomplex subunit 10-A
- At2g31490
- Uncharacterized protein At2g27730
- NADH dehydrogenase flavoprotein 2, mitochondrial
Sequence:
MAKPLGTTGEFFRRRDEWRKHPMLSNQMRHALPGLGIGVAAFCVYLVGEQIYNKALAPSKSSHHHQEQTAPSH
Protein: L-Ala-D/L-amino acid epimerase (EC 5.1.1.-) (L-Ala-D/L-Xxx epimerase) (B9I2J6)
Organism: Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)
Function: Catalyzes the epimerization of various hydrophobic and polar dipeptides. Has epimerase activity with L-Ala-L-Ala, L-Ala-L-Ser, L-Ala-L-Thr and L-Ala-L-Trp (in vitro).
Interaction partners:
- Ubiquitin-like domain-containing protein
- Ubiquitin-like domain-containing protein
- CCAAT-binding factor domain-containing protein
- MHD domain-containing protein
- MHD domain-containing protein
- Rhodanese domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Nucleolar protein 14
- MI domain-containing protein
Sequence:
MLSIGSLCLSLGTTPKPLKPSKTPKPIRKLYATKAMAGSNPKQVSTFEFRDLMETFAVDVKRAENRPLNVPLIAPFTIASSRLDKVENVAIRIELSDGCVGWGEAPILPFVTAEDQSTAMIKAREACELLKNSSSMKLGLVLERVSEILPGHEFASVRAGVEMALIDAVAKSINVPLWILFGGASDSITTDITIPIVSSAEAAELASKYRKQGFQTLKLKVGKNLKEDIEVLQAIRAVHPDCLFILDANEGYKPEEAIEVLEELHKMGVTPILFEQPVHRDDWEGLGHVTHIAKGKYGVSVAADESCRSLVDAKRIIKGNLADVINIKLAKVGVVGGLEIIEEARTSGLDLMIGGMVETRLAMGFAGHLAAGFGCFKFIDLDTPLLLSEDPVLEGYEVSGAVYKFTDAQGHAGFLDWDNVL
Protein: Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) (O51419)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS9
- Small ribosomal subunit protein bS16
- GTPase Era
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein bS6
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS15
Sequence:
MLLQKTLCIVKPDGVRRGLIGDVVSRFERVGLKMVAAKMLIVDESLAKKHYLYDDIVFRHSEAVWNSLIKFISNSPVFTFVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFKYSNEKGFSIYNVIHASANEADAMREIPIWFKDNEILNYKRDDECEHYYC
Protein: Membrane protein (Q0P9X3)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Interaction partners:
- Adenine phosphoribosyltransferase
- Ribose 5-phosphate isomerase
- Flagellar protein FliL
- Flagellar motor protein
- Integral membrane protein
- Ribosome-binding ATPase YchF
- Probable cytosol aminopeptidase
Sequence:
MFTNWLVLTILICATIYLIVMLFYYKTLLNKEKTSKDFIKNNLDDTEIVIRKLQIQLQRSLGNIDILTEELNKIKADLTSLRTRNSQYRLENDKLRQRIKELEAKIEALL
Protein: Probable WRKY transcription factor 33 (WRKY DNA-binding protein 33) (Q8S8P5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-TTGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Involved in defense responses. Required for resistance to the necrotrophic fungal pathogen B.cinerea. Regulates the antagonistic relationship between defense pathways mediating responses to the bacterial pathogen P. syringae and the necrotrophic pathogen B.cinerea. Required for the phytoalexin camalexin synthesis following infection with B.cinerea. Acts as positive regulator of the camalexin biosynthetic genes PAD3 (CYP71B15) and CYP71A13 by binding to their promoters. Acts downstream of MPK3 and MPK6 in reprogramming the expression of camalexin biosynthetic genes, which drives the metabolic flow to camalexin production. Functions with WRKY25 as positive regulator of salt stress response and abscisic acid (ABA) signaling. Functions with WRKY25 and WRKY26 as positive regulator of plant thermotolerance by partially participating in ethylene-response signal transduction pathway. The DNA-binding activity of WRKY33 is increased by SIB1 and SIB2.
Subcellular location: Nucleus {ECO:0000269|PubMed:17059405, ECO:0000269|PubMed:18839316, ECO:0000269|PubMed:21990940}.
Interaction partners:
- Protein MKS1
- Sigma factor binding protein 1, chloroplastic
- Mitogen-activated protein kinase 4
- Autophagy-related protein 18a
- Sigma factor binding protein 2, chloroplastic
- Mitogen-activated protein kinase 3
- Probable WRKY transcription factor 25
- Bifunctional dihydrocamalexate synthase/camalexin synthase
- Mediator of RNA polymerase II transcription subunit 16
- Mitogen-activated protein kinase 6
Sequence:
MAASFLTMDNSRTRQNMNGSANWSQQSGRTSTSSLEDLEIPKFRSFAPSSISISPSLVSPSTCFSPSLFLDSPAFVSSSANVLASPTTGALITNVTNQKGINEGDKSNNNNFNLFDFSFHTQSSGVSAPTTTTTTTTTTTTTNSSIFQSQEQQKKNQSEQWSQTETRPNNQAVSYNGREQRKGEDGYNWRKYGQKQVKGSENPRSYYKCTFPNCPTKKKVERSLEGQITEIVYKGSHNHPKPQSTRRSSSSSSTFHSAVYNASLDHNRQASSDQPNSNNSFHQSDSFGMQQEDNTTSDSVGDDEFEQGSSIVSRDEEDCGSEPEAKRWKGDNETNGGNGGGSKTVREPRIVVQTTSDIDILDDGYRWRKYGQKVVKGNPNPRSYYKCTTIGCPVRKHVERASHDMRAVITTYEGKHNHDVPAARGSGYATNRAPQDSSSVPIRPAAIAGHSNYTTSSQAPYTLQMLHNNNTNTGPFGYAMNNNNNNSNLQTQQNFVGGGFSRAKEEPNEETSFFDSFMP
Protein: Inactive protein-tyrosine phosphatase egg-4 (Egg sterile protein 4) (Protein-tyrosine phosphatase-like protein egg-4) (O01767)
Organism: Caenorhabditis elegans
Function: Inactive phosphatase which acts redundantly with egg-5 in the oocyte-to-zygote transition. Required for the polarization of cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-5, required for the cortical localization of kinase mbk-2 and for the inhibition of mbk-2 kinase activity in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:19879147}. Note=Co-localizes with egg-3 to the cell cortex in developing oocytes and in newly fertilized embryos; cortical localization requires egg-3 and chitin synthase chs-1. At the beginning of meiosis anaphase I, egg-4 moves away from the cell cortex and is likely degraded. {ECO:0000269|PubMed:19879147}.
Interaction partners:
- Inactive protein-tyrosine phosphatase egg-5
- Chondroitin proteoglycan-2
- Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2
- LDL receptor repeat-containing protein egg-1
- PUM-HD domain-containing protein
- Chitin synthase chs-1
- Chondroitin proteoglycan 1
- LDL receptor repeat-containing protein egg-2
- PUM-HD domain-containing protein
- EGF-like domain-containing protein
Sequence:
MALNSEVMFREQINAMRSQAGRKRATSLQSFCSGNTDDSSADSTDNMDMMVDYPQQKGVSCMRARFNSESTLSKSFRKKVKKLAQKDRRSKERLNGNSEEDAIEVPRGAPSTYAAPSKLRKSKALDCLVSEKPKDEGRREDSGHGADIEMAKGHFNNVRMKVFAARTAMQVEPALVMKTRKALEMKNAVLENHQSPGAFSLHAAYKIAASAESRVGSITPCNKKVTKEAMANLIRSSYDDTEITQELLFSSKFDTKWKGRYTDIYMRRDENGKKPKRPVNGQGWVMPLKSICEKFGINSTFFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHPEAVKNETMAEYLLRELDASTMQKRVQAFKANVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDVIGSAKELDVDYERWLQERSERMFLDDLAAPIPGYRLLSPRADPDIVRMVGRPERPNYRREAPDCVGEMPNKVATVDGILSPAKSVFEF
Protein: Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) (Q9GZY6)
Organism: Homo sapiens (Human)
Function: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734}; Single-pass type III membrane protein {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734}. Note=Present in lipid rafts.
Interaction partners:
- Growth factor receptor-bound protein 2
- Linker for activation of T-cells family member 1
- Tyrosine-protein kinase SYK
- Lymphocyte cytosolic protein 2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- Tyrosine-protein kinase Lyn
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Son of sevenless homolog 1
- SHC-transforming protein 1
- GRB2-related adapter protein 2
Sequence:
MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA
Protein: Spindle pole body component 97 (DdSpc97) (Spc97) (Q95ZG3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May be involved in microtubule nucleation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm.
Interaction partners:
- Tubulin gamma chain
- Spindle pole body component 98
Sequence:
MKQNQPNLNVNLNNRLQQQQLNQVAQQQLQQQPLKNTKQNPINNQTNGILNNKPITTSSNIMNSDNILNNNNNNNTNKPSSTFNFNITNTPPPPVNKQKPITSSSTSKPSNTTTTTTTTTTTTKPPSNSLPSSSSSKVKVNSLTSQNNNNNNSNTNTNMTTQPPTFNNLIKPQSLPSTTGMNEIKNTPTRTTTTTSTQHTKYIKEDIVVKENNNRISNMNNNNISGASGGTTFNSYNYLPNNTLDNFINNSNTTTTTTNNNTNNNNNNNNNNNIINNIKQQHELELLQQKHIEEMKILQNEQLNQLKKQQKKLNESDTDGSDDDDDDDDEYGENMNLSPRTLRELKNIQRLKNLEKFSPPYLITKKTSPSIKTLPKFPEWTKERPFLNYGYLANISTNYTSLILPSKYEQTKIQLSSIPNYFREQILIEDLLSTMIGIEGECIHIGVVQENEDDSLQSNLVSFVVEGEVDPSNNDLVQRILPLCSYYSFVNDFIQIRYAYEWGIINHSLCFSIDQLLKEYLVLVSQLEGQLKSERLSLQRMWFYLQPTIKTFEILYRVTSEIMRCNSHGVQVINLLLKLQSKYSSDKKTDDLFHYLIKATTLPFLEMLDLWIHQGIIRDTYFEFMIEENTDLKRDNINRDFNDLYWEQRYQIRQDQIPKYLQSHALKILTTGKYLNVVRECNQSISQQQQHNKSDNNNNNNNNVKLNSQQQLLLLKLNTTQQQQQQQLSSTSASMIPTTIIEYSKNENVYIDKIEKAYDYASGILLNLLINERHLISRLKAIKHYFLLCKGDFFSHFMDTTYDELKKPLDQINMVKMNSLLQLSLRTSSISEEDEFKDDLECEFIPYKLVDQLLNIININNFNNPTTTTTTNTSSNNITATTNTSSNNTTINTTVNTTLIQSTSAHEVLKTNKLFGIESLAFNYNVGWPLSLIISRKSLIKYQIIFRHLFLCKHVEKVLVDTWSQHQFRRSSYNKPGLSTLLSFTHLLRHRMIHFLQNLEYYMMLEVLEPNWNKMKNSIKTSKTVDDVIRIHNDFLETCLTECMLTDTKLVNILMKFMSLCITFANFTNEMMQDEKNIDTEQIKKTISSSENKFHAILKVLMDTLKSFSKTESNRHMIHLIHRLDYNGYYSHYFENNPNLFKNKTSSSSNKSNNVSPPLEPRFSYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKQNQIQQQKQNQIQQQQQQSRGSTLPSNFSFQTALQQQINTTSATTTTSNQSPHTLIDDLKKRAYGILDSNNTKKTLERTSSSPALDNQSNSLPMTQSISQYAEKLKNLRAVIKNDELK
Protein: Myoglobin (Nitrite reductase MB) (EC 1.7.-.-) (Pseudoperoxidase MB) (EC 1.11.1.-) (P84997)
Organism: Bubalus bubalis (Domestic water buffalo)
Function: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
Subcellular location: Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:P02144}.
Interaction partners:
Sequence:
MGLSDGEWQLVLNAWGKVETDVAGHGQEVLIRLFTGHPETLEKFDKFKHLKTEAEMKASEDLKKHGNTVLTALGGILKKKGHHEAEVKHLAESHANKHKIPVKYLEFISDAIIHVLHDKHPSDFGADAQAAMSKALELFRNEMAAQYKVLGFHG
Protein: Aldehyde dehydrogenase (ALDDH) (ALDH) (EC 1.2.1.3) (P08157)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Acetyl-coenzyme A synthetase
- Pyruvate decarboxylase
- Pyruvate decarboxylase
- Alcohol dehydrogenase 1
- Oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptor
- 4-aminobutyrate aminotransferase
- Acetyl-CoA hydrolase
- Glutamate decarboxylase
- Glutamate decarboxylase
- FMN dependent dehydrogenase, putative
Sequence:
MSDLFTTIETPVIKYEQPLGLFINNEFVKGVEGKTFQVINPSNEKVITSVHEATEKDVDVAVAAARAAFEGPWRQVTPSERGILINKLADLMERDIDTLAAIESLDNGKAFTMAKVDLANSIGCLRYYAGWADKIHGQTIDTNPETLTYTRHEPVGVCGQIIPWNFPLLMWSWKIGPAVAAGNTVVLKTAEQTPLSALYAAKLIKEAGFPAGVINVISGFGRTAGAAISSHMDIDKVAFTGSTLVGRTILQAAAKSNLKKVTLELGGKSPNIVFDDADIDNAISWANFGIFFNHGQCCCAGSRILVQEGIYDKFVARFKERAQKNKVGNPFEQDTFQGPQVSQLQFDRIMEYINHGKKAGATVATGGDRHGNEGYFIQPTVFTDVTSDMKIAQEEIFGPVVTIQKFKDEAEAIKIGNSTDYGLAAAVHTKNVNTAIRVSNALKAGTVWINNYNMISYQAPFGGFKQSGLGRELGSYALENYTQIKTVHYRLGDALFA
Protein: Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) (P07237)
Organism: Homo sapiens (Human)
Function: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:32149426}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:23475612}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cell membrane {ECO:0000269|PubMed:21670307}; Peripheral membrane protein {ECO:0000305}. Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces (PubMed:11181151). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:10636893). Colocalizes with MTTP in the endoplasmic reticulum (PubMed:23475612). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:11181151, ECO:0000269|PubMed:23475612, ECO:0000305}.
Interaction partners:
- Prolyl 4-hydroxylase subunit alpha-2
- Endoplasmic reticulum chaperone BiP
- Microsomal triglyceride transfer protein large subunit
- ERO1-like protein alpha
- Calreticulin
- Prolyl 4-hydroxylase subunit alpha-1
- ERO1-like protein beta
- Endoplasmin
- Prolyl 4-hydroxylase subunit alpha-3
- Calnexin
Sequence:
MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEAEEPDMEEDDDQKAVKDEL
Protein: Rab GTPase-activating protein 1-like (Q5R372)
Organism: Homo sapiens (Human)
Function: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP. Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).
Subcellular location: Cytoplasmic vesicle {ECO:0000250|UniProtKB:A6H6A9}. Early endosome {ECO:0000269|PubMed:16923123}. Golgi apparatus {ECO:0000269|PubMed:16923123}. Note=Colocalizes on endosomes partially with EEA1 (PubMed:16923123). Colocalizes and cotransports on motile vesicles with ANK2 (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}.
Interaction partners:
Sequence:
MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQLKIVSNGDEQLEKAMEEILRDSEKRPSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQLILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQYPFPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL
Protein: Zinc transporter 9 (ZRT/IRT-like protein 9) (O82643)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Zinc transporter involved in zinc uptake in roots. Targeted by BZIP19 transcription factor in response to zinc-deficient conditions.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Basic leucine zipper 19
- Putative zinc transporter At3g08650
- Basic leucine zipper 23
- Putative cadmium/zinc-transporting ATPase HMA4
- Metal tolerance protein 1
- TPR repeat-containing protein ZIP4
- Protein yippee-like At4g27740
- Metal tolerance protein A2
- Nicotianamine synthase 2
- IAA-alanine resistance protein 1
Sequence:
MASILISGAAGVSIPLVGTLLPLNGGLMRGAKAFAAGVILATGFVHMLSGGSKALSDPCLPEFPWKMFPFPEFFAMVAALLTLLADFMITGYYERKQEKMMNQSVESLGTQVSVMSDPGLESGFLRDQEDGGALHIVGMRAHAEHHRHSLSMGAEGFEALSKRSGVSGHGHGHSHGHGDVGLDSGVRHVVVSQILEMGIVSHSIIIGISLGVSHSPCTIRPLLLALSFHQFFEGFALGGCVAEARLTPRGSAMMAFFFAITTPIGVAVGTAIASSYNSYSVAALVAEGVLDSLSAGILVYMALVDLIAADFLSKKMSVDFRVQVVSYCFLFLGAGMMSALAIWA
Protein: Phytosulfokine receptor 2 (AtPSKR2) (EC 2.7.11.1) (Phytosulfokine LRR receptor kinase 2) (Q9FN37)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phytosulfokine receptor with a serine/threonine-protein kinase activity.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein-tyrosine sulfotransferase
- ATPase 1, plasma membrane-type
- Cyclic nucleotide-gated ion channel 17
- Phytosulfokines 2
- Phytosulfokines 3
- Putative phytosulfokines 4
- Phytosulfokines 5
- Protein PSY1
- ATPase 2, plasma membrane-type
Sequence:
MVIILLLVFFVGSSVSQPCHPNDLSALRELAGALKNKSVTESWLNGSRCCEWDGVFCEGSDVSGRVTKLVLPEKGLEGVISKSLGELTELRVLDLSRNQLKGEVPAEISKLEQLQVLDLSHNLLSGSVLGVVSGLKLIQSLNISSNSLSGKLSDVGVFPGLVMLNVSNNLFEGEIHPELCSSSGGIQVLDLSMNRLVGNLDGLYNCSKSIQQLHIDSNRLTGQLPDYLYSIRELEQLSLSGNYLSGELSKNLSNLSGLKSLLISENRFSDVIPDVFGNLTQLEHLDVSSNKFSGRFPPSLSQCSKLRVLDLRNNSLSGSINLNFTGFTDLCVLDLASNHFSGPLPDSLGHCPKMKILSLAKNEFRGKIPDTFKNLQSLLFLSLSNNSFVDFSETMNVLQHCRNLSTLILSKNFIGEEIPNNVTGFDNLAILALGNCGLRGQIPSWLLNCKKLEVLDLSWNHFYGTIPHWIGKMESLFYIDFSNNTLTGAIPVAITELKNLIRLNGTASQMTDSSGIPLYVKRNKSSNGLPYNQVSRFPPSIYLNNNRLNGTILPEIGRLKELHMLDLSRNNFTGTIPDSISGLDNLEVLDLSYNHLYGSIPLSFQSLTFLSRFSVAYNRLTGAIPSGGQFYSFPHSSFEGNLGLCRAIDSPCDVLMSNMLNPKGSSRRNNNGGKFGRSSIVVLTISLAIGITLLLSVILLRISRKDVDDRINDVDEETISGVSKALGPSKIVLFHSCGCKDLSVEELLKSTNNFSQANIIGCGGFGLVYKANFPDGSKAAVKRLSGDCGQMEREFQAEVEALSRAEHKNLVSLQGYCKHGNDRLLIYSFMENGSLDYWLHERVDGNMTLIWDVRLKIAQGAARGLAYLHKVCEPNVIHRDVKSSNILLDEKFEAHLADFGLARLLRPYDTHVTTDLVGTLGYIPPEYSQSLIATCRGDVYSFGVVLLELVTGRRPVEVCKGKSCRDLVSRVFQMKAEKREAELIDTTIRENVNERTVLEMLEIACKCIDHEPRRRPLIEEVVTWLEDLPMESVQQQ
Protein: Small ribosomal subunit protein mS46 (37S ribosomal protein RSM28, mitochondrial) (Q03430)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:15701796, ECO:0000269|PubMed:16823961}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein uS4m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS3m
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein mS37
- Small ribosomal subunit protein bS1m
- Small ribosomal subunit protein mS42
- Small ribosomal subunit protein bS21m
- Small ribosomal subunit protein mS26
- Small ribosomal subunit protein mS27
Sequence:
MRSSMFRCVSRAHYSTSVTEDFINSILARAQEATAKASSNALKLDKMKEGRMQNKRRNGNQNRNSMNNKESRGREGNQGERNMRLKNRSSDSVRANKQQWNKGANTSFVKNPTGNTVVMQPQFKKMQNGKNNLKGDARVEDDLLDVFNSSMEQKPVNFNGTPKSKARFQKKSHILTASKRRKAPQQQLQKVIKRPVSSEYVLEEPTPLSLLEYTPQVFPTKESRLVNFTLDSLKKSNYPIYRSPNLGILKVHDFTLNTPNFGKYTPGSSLIFAKEPQLQNLLIEEDPEDFHRQVTGEYQLLKPYVKKDFEKLTKSKDTVSKLVQNSQVVRLSLQSVVMGSEEKKLVYDVCSGMKPISELQQ