wanglab/gogpt-training-data huggingface dataset:
Protein: Small ribosomal subunit protein uS8z/uS8w (40S ribosomal protein S15a-1) (P42798)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm.
Interaction partners:
- Small ribosomal subunit protein eS28z/eS28y
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein uL23y
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS7x
- Large ribosomal subunit protein uL16x
- Large ribosomal subunit protein uL16z
- Small ribosomal subunit protein eS28x
- Small ribosomal subunit protein eS1z
Sequence:
MVRISVLNDALKSMYNAEKRGKRQVMIRPSSKVIIKFLIVMQKHGYIGEFEYVDDHRSGKIVVELNGRLNKCGVISPRFDVGVKEIEGWTARLLPSRQFGYIVLTTSAGIMDHEEARRKNVGGKVLGFFY
Protein: 2-formylbenzoate dehydrogenase (EC 1.2.1.78) (2-carboxybenzaldehyde dehydrogenase) (2-CBAL dehydrogenase) (2-formylbenzoate:NAD(+) oxidoreductase) (Q79EM7)
Organism: Nocardioides sp. (strain KP7)
Function: Plays a role in phenanthrene catabolism by catalyzing the oxidation of 2-carboxybenzaldehyde to phthalic acid. Not active with 3-carboxybenzaldehyde, 4-carboxybenzaldehyde, benzaldehyde, salicylaldehyde, 2-methylbenzaldehyde, 2-chlorobenzaldehyde, 2-fluorobenzaldehyde, 2-benzaldehydesulfonate, 2-methoxybenzaldehyde, 1-hydroxy-2-naphthoaldehyde or n-hexylaldehyde.
Interaction partners:
Sequence:
MTTPRKFDEYRWNVLVDGVPLNVESRYPISDPSTGRYLTQVPDCAEADVDRAVQASRQAQAEWGALPPRARAAKLRELITLLREHREEFAMLDAIDGGFPISMMRNDVDAALELMDIFADMALDLGGKTIPVSTNLHFTTHEPFGVVARIGAFNHPFFFAASKVAAPLMAGNSVILKAPDQTPLSSLRLAEVAAEVLPQNLLITISGRGRVAGRAIVRHPQIKRIGFIGSTDTGRSIQRDAAEVAVKHISLELGGKNAQIVFADADLEQAALGAVNGMNFTWTAGQSCGSTSRLLVHESVADQVIARVVELVSAIAVGPPLDENAQMGPLVSQAQYDKSVHAIGEGIREGAKVVAGGGRPEGVGEGGWYLAPTVLADVRPGSFIEQNEIFGPVLSVIIFATDDEAVAIANGVEYGLTASVWTSDITRAHLIARRVEAGYVLVNGGSRHYWGLPFGGVKSSGVGSEESMEELISYTETKTTTVVLG
Protein: Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Q99LG0)
Organism: Mus musculus (Mouse)
Function: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03062}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03062}.
Interaction partners:
- Deubiquitinase MYSM1
Sequence:
MGKKRTKGRSAPDTVASESAEPVCRHLRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKPEEEAEDPSVWLCLKCGHQGCGRDSQEQHALKHYTTPRSEPHYLVLSLDNWSVWCYKCDEEVKYCSSNRLGQVVDYVRKQAGVRTSKPAEKNNGHIELENKKLEKESKNEQEREKSENLAKETIPMDSASQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEVNLEPPGPLTLAMSQFLSEMQENKKRVVTPKELFSQVCKKATRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEEVKNKVKDYEKKKAIPSFVDRIFGGELTSTIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSINDKNVKMTMEEEDKDSEEEKDDSYMKSRSDLPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQERFLHFNELCATDYTEDNEREADTALAGEVEVDTDSTHGSQEEATQIELSVNQKDLDGQESMIERTPDVQESPEDLGVKSANTESDLGIVTPAPECPRDFNGAFLEERTSGELDIINGLKNLNLNAAVDPDEINIEIPNDSHSAPKVYEVMNEDPETAFCTLANREAFSTDECSIQHCLYQFTRNEKLQDANKLLCEVCSRRQCNGPKANIKGDRRHVYTNAKKQMLVSLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEESTRVLYSLYGVVEHSGTMRSGHYTAYAKERTASCHLSNLVLHGDIPQDCEMESTKGQWFHISDTHVQAVPITKVLNSQAYLLFYERIL
Protein: Integrin alpha-6 (VLA-6) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain] (P26007)
Organism: Gallus gallus (Chicken)
Function: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P23229}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P23229}; Lipid-anchor {ECO:0000250|UniProtKB:P23229}.
Interaction partners:
- Integrin beta-1
- Laminin subunit alpha 3.
- Laminin subunit beta-1
- Laminin subunit alpha 5.
- Laminin subunit beta 3.
- Uncharacterized protein.
- Laminin subunit alpha 4.
- Uncharacterized protein.
- Laminin subunit gamma 1.
- Proto-oncogene tyrosine-protein kinase Src
Sequence:
MAAALLLYLPLLPGLAGAFNLDAENVIGRRGEPGSLFGFSLAMHRQLQPQEKRLLLVGAPREKAFPSQQANRTGGLYSCDITSSDTRCTRVVFDEDTDPKMESKEDQWMGVTVQSQGPGGNVVTCAHRYEKRQYVNTVQETRDIIGRCYVLSQDLTIKDDMDNGVWSFCDGRLRGHEKFGSCQQGVAATFTRDYHYIVFGAPGTYNWKGVVRAEQKNQTFYDLGIFDDGPYEVGDESRQDKNLVPVPANSYLGFSLDSGKGIVSQDEMTFVSGAPRANHSGAVVLLKKEKNQRALSLEHMFEGEGLASSFGYDVAVVDLNSDGWQDIVVGAPQYFDRSGDIGGAVYIYINQRGKWEGIKPIRLNGTADSMFGLAVENVGDINQDGYPDIAVGAPYDGFGKVYIYHGSKNGINTEPAQILDGEKTGTNFFGYSIAGNMDLDKNSYPDIAVGSLSDSVSVFRSRPVISITKSITVQPDKLDLKKKNPEDPSEIWMDVKACFQYTANPRNLNPRIKINYTFEAENERRQLGLPSRVRFKDYLSDQFTASTTLIGQNSKRCVTAKLVLQEKIKDKLRPIPIAVSVNIAGLESGSSSTRKERALPDLIPILNSNESETKITKVEFLKEGCGEDNECHSNLKLQYRFCTREGNEDRFTYLPIENGIPVLVLKDQKDIALEITVTNNPSDARNPQKDGEDAYEAKLIATFPDSLTYSAFREMRGYPEKQLTCGANQNGSQAECELGNPFKRNSNVTFYLILSTTKVNVDTTDLDINLKLETTSTQVNSTAITASAKVVLELLLSLTGVAKPSQVYFGGNIVGESAMKSEDNIGNLIEYEFRVTNLGRPLKTFGTASLDIQWPKEISNGKWLLYLMKIESKGLEKVSCQPQNEINVLHVAESHNSRRKREIAEKQLTDSKTFSLFSERKYKTLDCKVNAQCVDIRCPLKGFDSKASILLRSRLWNSTFLEEFSKMNYLDILVRASISVPAAAKNVKLTNEAAQVRVTVFPAKPVALYTGVPWWIIAVAIFAGVLMLALLVFLLWKCGFFKRSKKDHYDATYHKAEIHAQPSDKERLTSDA
Protein: RAB30, member RAS oncogene family (H0YDK7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
YCRDIHTKYSSEWGAGALEDKSRLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEARQNTLVNNVSSPLPGEGKSISYLTCCNFN
Protein: TATA-box-binding protein (zTBP) (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (zfTBF) (Transcription initiation factor TFIID TBP subunit) (Q7SXL3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subset of genes at the mid-blastula transition (MBT). Negatively regulates the expression of other embryonic genes, including autoregulation of the tbp promoter itself. Also functions within a transcription-dependent mechanism to direct the temporally-regulated degradation of a subset of maternal mRNAs after the MBT. This is part of a general mechanism to regulate the maternal to zygotic transition and is required for normal embryonic development. Binds to promoters of a subset of genes. Required for gastrulation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P20226}.
Interaction partners:
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 9
- TAF11 RNA polymerase II, TATA box-binding protein
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit
- TAF7 RNA polymerase II, TATA box-binding protein
- Transcription initiation factor TFIID subunit 2
- General transcription factor IIB.
- TATA-box-binding protein-associated factor 13.
Sequence:
MEQNNSLPPFAQGLASPQGAMTPGLPIFSPMMPYGTGLTPQPVQNSNSLSLLEEQQRQQQQQQAASQQQGGMVGGSGQTPQLYHSTQAVSTTTALPGNTPLYTTPLTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRGEIYEAFENIYPILKGFRKTS
Protein: Lipin, isoform G (EC 3.1.3.4) (A0A0B4JCS1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDKNASEELLLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTTQKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQIKPDVNLTTVTTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNIDEGDAPISSATNNNNTSSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPRLDLDIHFFSDTEITTPVGGGGAGSGRAAGGRPSTPIQSDSELETTMRDNRHVVTEESTASWKWGELPTPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIYLSDLDAGSMDPEMAALYFPSPLSKAASPPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNNRYLDFVAMSMCGMSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYTWMAACPIVMTMITFQKPLTHDAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQDAAPNHLNNTHGMPLGKDEKDGDQAAVATQTSRPTSPDITDPTLSKSDSLVNAENTSALVDNLEELTMASNKSDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVISDIDGTITKSDVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYLRSIRQGNVMLPDGPLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDLFPDKEPFYAGYGNRINDVWAYRAVGIPIMRIFTINTKGELKHELTQTFQSSGYINQSLEVDEYFPLLTNQDEFDYRTDIFDDEESEEELQFSDDYDVDVEHGSSEESSGDEDDDEALYNDDFANDDNGIQAVVASGDERTADVGLIMRVRRVSTKNEVIMASPPKWINS
Protein: DNAJ heat shock N-terminal domain-containing protein (F4HWD5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- UDP-rhamnose/UDP-galactose transporter 1
- UDP-rhamnose/UDP-galactose transporter 2
- UDP-rhamnose/UDP-galactose transporter 5
- UDP-rhamnose/UDP-galactose transporter 6
- UDP-rhamnose/UDP-galactose transporter 3
- UDP-rhamnose/UDP-galactose transporter 4
- UDP-URONIC ACID TRANSPORTER 1
- ER membrane protein complex subunit 3
Sequence:
MVKETEFYDVLGVSPTATEAEIKKAYYIKARQVHPDKNPNDPQAAHNFQVLGEAYQVLSDPGQRQAYDTSGKSGISTEIIDPAAIFAMLFGSELFEEYIGQLAMASMASLDIFTEGDQIDTKKIIEKMRAVQKEREDKLAQILKDRLNLYMTNKDEFTSNAEAEVTRLSNAAYGVEMLNTIGYIYVRQAAKELGKKAIYLGVPFVAEWFRTKGHFIKSQVTAATGAYALFQLQEEMKRQLSAEGNYTEKELEEYMKTHKKVMIDSLWKLNVADIESTISRVCEQVLQDPTAKREELRARAKGLKTLGKIFQKNKIASESDPLVRAELHKLNGNGQEHDHSSTSPKSDEASRSTVGPQPEVETVSLVEPQSPYVEAPKLGEEQINYYFPRPAPPPGAQRHS
Protein: Uncharacterized transporter PB1C11.03 (Q9C0U9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Probable proline-specific permease put4
- Uncharacterized amino-acid permease C74.04
- Sexual differentiation process putative amino-acid permease isp5
Sequence:
MTESIISSRTASISSKEGYEIRQGSTDSSSLDLEKKENAVDTTIAKPFDSDEDIADVEKAGGKKINNSLIDETFAFMQDAKKLDPLTPKQESKLKWKLYIYLLLMLGFLDMMLFIGKATLSYSTILGLFDDVHITSNQYNNLNTLFYVGYIVGQFPGHYIMQTFPLGKFVGLVTFSWSVIVFLHCCAYNYGGLIALRFFLGFTESCLLPAMEATMGMFFTHQEQAFLQPVFWISCLSCGIPAGFIAYGLEFVTKSIAPWKLFMIITGGITFFLSIFLFFYYPDNPSKARFLTDEEKLYTIDRVRKSTRGGIENKIFKKHQFIEALKDPITWLFTFAAFTLMLSNNLAYQQNLIFTSLNVSDLNSTLVGVALAGYNTVSAIIATFAMYLIPNQSAYHAMFWMLPSITGGIAFVALPWSNRIGELATMIIASDFGITYIIALGWTTATSTGYTKKLTRGLMFMVGYAIANIISPQLWQSRDAPRYYPAWIVQIVVAWFVTPIIYLVARVILARRNKQRKELKDKKIAEGSLETIEKTYVDTVDEFGNPVKVLIDNSMLDLTDMENLNFVYPL
Protein: Fatty acid-binding protein, intestinal (B5XAH0)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MTYNGTWKVDRSENYEKFMEQMGVNMVKRKLAAHDNLKITLEQTGDKFVVKEASSFRTLDMEFTLGVTFEYALADGTMLSGSWGMEGDMMKGTFTRKDNGKVLKTTRAIVGEELVQSYSYDGVEAKRIFKRG
Protein: Copper-transporting ATPase RAN1 (EC 7.2.2.8) (Protein HEAVY METAL ATPASE 7) (Protein RESPONSIVE TO ANTAGONIST 1) (Q9S7J8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in copper import into the cell. Essential for ethylene signaling, which requires copper. Acts by delivering copper to create functional hormone receptors.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Copper chaperone for superoxide dismutase, chloroplastic/cytosolic
- Copper transport protein CCH
- Copper transport protein ATX1
- Heavy metal transport/detoxification superfamily protein
- Copper transporter 5
- Heavy metal-associated isoprenylated plant protein 23
- RING-type E3 ubiquitin transferase
- Heavy metal-associated isoprenylated plant protein 6
Sequence:
MAPSRRDLQLTPVTGGSSSQISDMEEVGLLDSYHNEANADDILTKIEEGRDVSGLRKIQVGVTGMTCAACSNSVEAALMNVNGVFKASVALLQNRADVVFDPNLVKEEDIKEAIEDAGFEAEILAEEQTQATLVGQFTIGGMTCAACVNSVEGILRDLPGVKRAVVALSTSLGEVEYDPNVINKDDIVNAIEDAGFEGSLVQSNQQDKLVLRVDGILNELDAQVLEGILTRLNGVRQFRLDRISGELEVVFDPEVVSSRSLVDGIEEDGFGKFKLRVMSPYERLSSKDTGEASNMFRRFISSLVLSIPLFFIQVICPHIALFDALLVWRCGPFMMGDWLKWALVSVIQFVIGKRFYVAAWRALRNGSTNMDVLVALGTSASYFYSVGALLYGAVTGFWSPTYFDASAMLITFVLLGKYLESLAKGKTSDAMKKLVQLTPATAILLTEGKGGKLVGEREIDALLIQPGDTLKVHPGAKIPADGVVVWGSSYVNESMVTGESVPVSKEVDSPVIGGTINMHGALHMKATKVGSDAVLSQIISLVETAQMSKAPIQKFADYVASIFVPVVITLALFTLVGWSIGGAVGAYPDEWLPENGTHFVFSLMFSISVVVIACPCALGLATPTAVMVATGVGATNGVLIKGGDALEKAHKVKYVIFDKTGTLTQGKATVTTTKVFSEMDRGEFLTLVASAEASSEHPLAKAIVAYARHFHFFDESTEDGETNNKDLQNSGWLLDTSDFSALPGKGIQCLVNEKMILVGNRKLMSENAINIPDHVEKFVEDLEESGKTGVIVAYNGKLVGVMGIADPLKREAALVVEGLLRMGVRPIMVTGDNWRTARAVAKEVGIEDVRAEVMPAGKADVIRSLQKDGSTVAMVGDGINDSPALAAADVGMAIGAGTDVAIEAADYVLMRNNLEDVITAIDLSRKTLTRIRLNYVFAMAYNVVSIPIAAGVFFPVLRVQLPPWAAGACMALSSVSVVCSSLLLRRYKKPRLTTVLKITTE
Protein: Endonuclease/exonuclease/phosphatase family domain-containing protein 1 (Q7L9B9)
Organism: Homo sapiens (Human)
Interaction partners:
- Protein IWS1 homolog
- FACT complex subunit SPT16
Sequence:
MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLLAEQQPHHLATAVPLTPRVNINTATPAQLMSVRGLSEKMALSIVDFRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCTELNQPTLPNIRKWKGPRGCWKAVVAEKPSSQLQKGAGYAGFLWDAAAGMELRDAGSQESSPSNGHGKLAGPSPYLGRFKVGSHDLTLVNLHLAALTLLGSENPSKNHSDGHRLASFAQTLQETLKGEKDVIILGDFGQGPDSNDYDILRKEKFHHLIPAHTFTNISTKNPQGSKSLDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDWSKKDAPRNGSGVALERSEANIKHER
Protein: Plasma membrane iron permease (Q09919)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Permease for high affinity iron uptake.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Iron transport multicopper oxidase fio1
- Ferric reductase transmembrane component 1
- Iron-sensing transcriptional repressor
- Siderophore iron transporter 1
- Ferric/cupric reductase transmembrane component 2
Sequence:
MAKDVFSVAIFFIVLRETLEASIIVSVLMSFISQTLMDKDGNVTDPKLKRKFMLQVWIGSFTALFICLAIGGGFIGAFYALDKDIWSGSEEIWEGVFSLIAVVLITVMGFAMLRVSHLQEKWRKKLMKSIANRKAKGISNWGKKYSMFLLPFFTVLREGLEVVVFVGGVGLETPATAFPLPVICGLIVGCLIGYFIYRGGNVMNLQWFLIASTCILYLISAGLMSKATFYFEMNKWNHQTGGDAGELGDGPGSYPFKSAVWHVNYGNPEMNSNGGYMIFNAILGWNNTGTYGSILSYIIYWLFVAFIMFLMWYKERRAARLLIAKLGDKVVDLEAASSHTPVQSSSSEDEFKINSPTDDKGDKAIDIVTEVRESSSPVEEHKDDKTVDVINEIRESH
Protein: Zgc:153779 (A0JMI1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MNSAIKVTNSTAIRAEVRRHENLQKTINKFIKQLERVEDQQLRTGLKVFLHSIQASCANSQEWTLTRTIPELRLGVLGSIRSGKSALVNRFITGSYLPLESHEGGRYKKEVLVEGQSQLLLIREESGPPSAQLCNWLDGLILVFSLENEASFQEVYKNYSELSAHRNIAEIPIIAVGTQDKISSTNARVIEDKRVQQLCIDVRRCTYYETCATYGLNVDRVFNEMTQKIVAAKKQAALLASCKSLPNSPSHSGASTPVSGPGQASNGAQSSDYPSSLPSTPVISHKDIRGGASRDGVTQRNPPRRRTSLFANRRGSDSEKRSSDSRSDTSRSVPIKQGTLWKRSERSLNKEWKKKYVTLSNSGMLTYHSNINEFLQNAQGKEMDLLRVTVKVPGKRLHRAAAPGAPSPGPALVPVPGVNGLSKDKQTPEGGAAPNLLTVEEASRAGLSYPNDQKVKRCPSSVSNKGFSVDSSIEGVTSPPLGKEHMPSSPMTDRKKKKRNRSINLKGDAAAGQAEEEESVDFIIISSTGQSWHFEAQSQEDRDAWVQAIESQILASLQSCESRNKARRNSQSEAVALQAIRNAKGNDLCVDCAAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDVWPSELTKVLSAIGNHMANHIWETCTQGCQKLTPEATREQRESWIRAKYEQRAFVSPLPAQCSEDTMSTWLLKAVINRDLPNLLLLLAHSTKELINIPPEGAGQQHHSALHAACQLGDVVMTQLLVWYGSDVKSKDPQGRTALTLARQAGSKECAEILVQHGCPSETSPTSPTPVLSRKSSITSVGRVNSRRRVS
Protein: Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a) (P11279)
Organism: Homo sapiens (Human)
Function: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity). Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:16176980}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16176980}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23847195}; Single-pass type I membrane protein {ECO:0000255}. Cytolytic granule membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:24088571}; Single-pass type I membrane protein {ECO:0000255}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). {ECO:0000250|UniProtKB:P05300, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}.
Interaction partners:
- Cathepsin D
- Lysosome-associated membrane glycoprotein 2
- Serine/threonine-protein kinase mTOR
- Regulatory-associated protein of mTOR
- GATOR1 complex protein NPRL2
- GATOR2 complex protein WDR24
- Protein SEC13 homolog
- GATOR1 complex protein NPRL3
- GATOR2 complex protein WDR59
- KICSTOR complex protein kaptin
Sequence:
MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNYDTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQAFKVEGGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI
Protein: Synaptotagmin-10 (Synaptotagmin X) (SytX) (O08625)
Organism: Rattus norvegicus (Rat)
Function: Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis.
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9R0N4}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses. Does not colocalize with synaptic vesicles or with the Golgi apparatus. {ECO:0000250|UniProtKB:Q9R0N4}.
Interaction partners:
Sequence:
MSFRKEDGVSSLCQKALHIITELCFAGQVEWDKCSGIFPADRSGQGGGGTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKLVAPNVSTLPQSISSAPTEVFETEEKKEVEENEKPAPKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQTTDPTSSSRHNSFRRHLPRQMNVSSVDFSMGTEPVLQRGETRTSIGRIKPELYKQKSVDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKIYLLPDRKKKFQTRVHRKTLNPLFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCSSPRPPSTP
Protein: C2H2 and C2HC zinc fingers superfamily protein (Putative C2H2-type zinc finger protein) (Zinc finger (C2H2 type) family protein) (Q9M344)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNRKYLDRRSYSWSGSQARPYICEFCERGFSNAQALGGHMNIHRKDRAKLRQANLKEEDSEDAICTTSRNRFGQELIELPFFVDTVGPRRKGEDDKSEKGLGDEEKKNMRILQKALSQSADVIDLELRLGLDPYKKTTSTST
Protein: Eukaryotic translation initiation factor 4E-1 (eIF-4E-1) (eIF4E-1) (eIF-4F 25 kDa subunit 1) (mRNA cap-binding protein 1) (P78954)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Interaction partners:
- Eukaryotic translation initiation factor 4 gamma
- ATP-dependent RNA helicase eIF4A
- Eukaryotic translation initiation factor 4E-2
- Probable eukaryotic translation initiation factor 5
- Polyadenylate-binding protein, cytoplasmic and nuclear
- Ran-specific GTPase-activating protein 1
- Small ribosomal subunit protein uS4B
- ATP-dependent RNA helicase ded1
- Small ribosomal subunit protein uS4A
- Nuclear cap-binding protein subunit 1
Sequence:
MQTEQPPKESQTENTVSEPQEKALRTVFDDKINFNLKHPLARPWTLWFLMPPTPGLEWNELQKNIITFNSVEEFWGIHNNINPASSLPIKSDYSFFREGVRPEWEDVHNKTGGKWAFQNKGRGGNALDEMWLTTVLAAIGETLDPTGQEVMGVVINMRKGFYRLAVWTKSCNNREVLMEIGTRFKQVLNLPRSETIEFSAHEDSSKSGSTRAKTRMSV
Protein: Abscisic stress-ripening protein 1 (Q08655)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Subcellular location: Nucleus {ECO:0000269|PubMed:8278555}.
Interaction partners:
Sequence:
MEEEKHHHHHLFHHKDKAEEGPVDYEKEIKHHKHLEQIGKLGTVAAGAYALHEKHEAKKDPEHAHKHKIEEEIAAAAAVGAGGFAFHEHHEKKDAKKEEKKKLRGDTTISSKLLF
Protein: Septin 9 isoform 3 (A0A0S2Z5W9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MERDRISATEAAPSCVGDMADTPRDAGLKQAPASRNEKAPVDFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEIKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKKRIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVHFKQRITADLLSNGIDVYPQKEFDEDSEDRLVNEKFREMIPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDITSSIHFEAYRVKRLNEGSSAMANGMEEKEPEAPEM
Protein: Sodium-dependent phosphate transport protein 2C (Sodium-phosphate transport protein 2C) (Na(+)-dependent phosphate cotransporter 2C) (Sodium/inorganic phosphate cotransporter IIC) (Sodium/phosphate cotransporter 2C) (Na(+)/Pi cotransporter 2C) (NaPi-2c) (Solute carrier family 34 member 3) (Q8N130)
Organism: Homo sapiens (Human)
Function: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q8K4R8}; Multi-pass membrane protein {ECO:0000255}. Note=ocalized at the brush border membrane in the kidney. {ECO:0000250|UniProtKB:Q8K4R8}.
Interaction partners:
- Na
- Sodium-dependent phosphate transport protein 2A
- Fibroblast growth factor 23
- Phosphate-regulating neutral endopeptidase PHEX
- Sodium-dependent phosphate transport protein 2B
- Klotho
- H
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Sodium-dependent phosphate transporter 2
- 1,25-dihydroxyvitamin D
Sequence:
MPSSLPGSQVPHPTLDAVDLVEKTLRNEGTSSSAPVLEEGDTDPWTLPQLKDTSQPWKELRVAGRLRRVAGSVLKACGLLGSLYFFICSLDVLSSAFQLLGSKVAGDIFKDNVVLSNPVAGLVIGVLVTALVQSSSTSSSIVVSMVAAKLLTVRVSVPIIMGVNVGTSITSTLVSMAQSGDRDEFQRAFSGSAVHGIFNWLTVLVLLPLESATALLERLSELALGAASLTPRAQAPDILKVLTKPLTHLIVQLDSDMIMSSATGNATNSSLIKHWCGTTGQPTQENSSCGAFGPCTEKNSTAPADRLPCRHLFAGTELTDLAVGCILLAGSLLVLCGCLVLIVKLLNSVLRGRVAQVVRTVINADFPFPLGWLGGYLAVLAGAGLTFALQSSSVFTAAVVPLMGVGVISLDRAYPLLLGSNIGTTTTALLAALASPADRMLSALQVALIHFFFNLAGILLWYLVPALRLPIPLARHFGVVTARYRWVAGVYLLLGFLLLPLAAFGLSLAGGMELAAVGGPLVGLVLLVILVTVLQRRRPAWLPVRLRSWAWLPVWLHSLEPWDRLVTRCCPCNVCSPPKATTKEAYCYENPEILASQQL