wanglab/gogpt-training-data huggingface dataset:
Protein: Chaperone protein DNAJ, putative (Q388Z0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDIDSPYKILGIPQSASVADIRAAFRRLALTTHPDKQGSNTSGGEAQMMLYSSHPFYVIKEASDILLDPVRRAEYDEGQQRMYARSIGVVSDVHDISDFRLVEERKALCSEDRVCGDVTIQVYEMECRCGGAFEIFLVKGEEGNMDKLCGCDSCSLIVSVRRQTQQ
Protein: Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) (Q80U57)
Organism: Mus musculus (Mouse)
Function: Regulates synaptic membrane exocytosis.
Subcellular location: Synapse {ECO:0000250}.
Interaction partners:
Sequence:
MFNGEPGPASAGASRNVVRSSSISGEICGSQQAGGGAGTTTAKKRRSSLGAKMVAIVGLTQWSKSTLQLPQPEGATKKLRSNIRRSTETGIAVEMRSRVTRQGSRESTDGSTNSNSSEGTFIFPTRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDVHIAIMDRSGQLEVEVIEARGLTPKPGSKSLPATYIKAYLLENGACVAKKKTKVAKKTCDPLYQQALLFDEGPQGKVLQVIVWGDYGRMDHKCFMGMAQIMLDELDLSAAVTGWYKLFPTSSVADSTLGSLTRRLSQSSLESATSPSCS
Protein: Uncharacterized protein (Q383V2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MAIARTTVTTVLDGLYFADRAVKMTHAAHRGCSFVCTPALLACTCPGTSVAVRLTPLSTGRPPLARMELLGQCAVSLFRAQRLAFHCAGEEGRAQMHELTLKRGDVIAVLGGCELDRDWGSVERTLKSVAHADLEYMAEEMLLELGRGTRRTGGGNGEVVSNSTCVMTVVQDRPSGLLPQPPSCLG
Protein: Pet100p (A0A1D8PES2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
- Copper metallochaperone
- Uncharacterized protein
Sequence:
MGFIRAFITRITRTQLETAKFGFYLLSPILVMYYVGLDTDKKFNLPGFWPDPSTLNQIPKEPHEIQAEIARIKRARLEKRKRLEEKARELGISEEDFEEEQQQEILS
Protein: Alpha-(1,3)-fucosyltransferase 4 (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Fucosyltransferase 4) (Fucosyltransferase IV) (Fuc-TIV) (FucT-IV) (Galactoside 3-L-fucosyltransferase) (Q62994)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (By similarity).
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Interaction partners:
- Galactoside alpha-
- Galactoside alpha-
- Type 2 lactosamine alpha-2,3-sialyltransferase
- Hexosyltransferase
- Histo-blood group ABO system transferase 2
- Histo-blood group ABO system transferase 1
- Glucosaminyl
- Beta-1,4-galactosyltransferase
- Beta-1,4-galactosyltransferase 4
- Hexosyltransferase
Sequence:
MAPAGRKLQHESRCRPSRPVDAWRAAATTRGRCMGTPGARRTARRGGWGLPRTSSGLAAAGLLCTALTACLCWGQLPPLPWASPAPQRPVSVLLWWEPFGGRGGHSKPPPDCSLRFNISGCRLLTDRAAYGEAQAVLFHHRDLVKGPPDWPPPWGAQERTDEALELRVFDDQEGAVMLAREALETTGSRPPGQRWVWMNFESPSHTPGLRGLAKDLFNWTLSYRTDSDIFVPYGFLYPRSHPAEQPSGLGPPLARKRGLVAWVVSHWNERQARVRYYHQLRRHVSVDVFGRAGPGQPVPAVGLLHTVARYKFYLAFENSQHVDYNTEKLWRNAFLAGAVPVLLGPDRANYEGFVPRGSFIHVDDFPSAASLAAYLLFLDRNVAVYRRYFHWRRSYAVHITSFWDEPWCQTCRAVQTSGDQPKSIHNLADWFQR
Protein: Uridine phosphorylase (EC 2.4.2.3) (A0A0S2Z6U5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVKFVCVGGSPNRMKAFALFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPSISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVILDNIVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLDYLKRAFKAGVRNIEMESTVFAAMCGLCGLKAKSTLIKPQTF
Protein: Thisbe, isoform B (A0A0B4K7X1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVVISGALCTVEDYVIMSQCAHNKAIHIAAEGTVSVTDTSQIQNITIVGFPDYLNNEFKIALYAKETRRYLCFNDNWRLVGMRELRDTCYFNETIVHGYFVFRSVVDLQRRVGFTHRGKPVGPKKSVNDACYMFNKIEAEQFFRHHHNNGNSGNNNGNGSGNDNGNGSNNSRKPPRNNKNNRHKSNNQNQKLQQQQEHHGHNNNNNNVILNNSNTSLSSTNKKQLAINRQRQQQQQHQVRHHHNDPSLLLRRQQHEKKQKRRKQQKQQQHQQRVSASPTNPMPATPTAAPAATPTVAATSPATATRSTTAAMSSKRKGRRRKAKVRPKAQQQQQLQLLATAATSPYTDDTLYGSSSSSSSTGFEDLDIYNSSSSSGSSSSLDPWSTWSTIDSFSGSSTTATSDDSISSSSSSNYDAWATYITEMEAEASAMTPEMGGNDTELMQYEAELVDDPEAESTATIETKATSVTSTIAATAATTTSTAGSQLVIEQTPLARSNISNKSSSSTKATPTATSQTETAQSTQQPSRHRSNSREDHLDNSDMLLAGENEVKPQQPRKLLWTVQPPLATRGSTLATLVATPEQQHTSTTATAATTPEQHVAPSLFSVDKNINSNLNNTLTEASPTATSTSSITSATTMKRPIRKFTKKLMATPYHQLTYVRNAGGDIDIDNLDNISVYPVLYDGDLEGNGGGNSSDGGFSGFLPTSTTSHLTEPIRIGMNRIRPNKTLHWFTHQRFA
Protein: 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase (EC 2.1.1.295) (2-methyl-6-phytylbenzoquinone/2-methyl-6-solanyl-1,4-benzoquinone methyltransferase) (MPBQ/MSBQ methyltransferase) (P74388)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Involved in a key methylation step in both tocopherol (vitamin E) and plastoquinone synthesis. Catalyzes the conversion of 2-methyl-6-phytyl-1,4-hydroquinol (MPBQ) to 2,3-dimethyl-6-phytyl-1,4-hydroquinol (DMPQ, a substrate for tocopherol cyclase), and 2-methyl-6-solanyl-1,4-benzoquinol (MSBQ) to plastoquinol.
Interaction partners:
- Slr1737 protein
- Homogentisate phytyltransferase
Sequence:
MPEYLLLPAGLISLSLAIAAGLYLLTARGYQSSDSVANAYDQWTEDGILEYYWGDHIHLGHYGDPPVAKDFIQSKIDFVHAMAQWGGLDTLPPGTTVLDVGCGIGGSSRILAKDYGFNVTGITISPQQVKRATELTPPDVTAKFAVDDAMALSFPDGSFDVVWSVEAGPHMPDKAVFAKELLRVVKPGGILVVADWNQRDDRQVPLNFWEKPVMRQLLDQWSHPAFASIEGFAENLEATGLVEGQVTTADWTVPTLPAWLDTIWQGIIRPQGWLQYGIRGFIKSVREVPTILLMRLAFGVGLCRFGMFKAVRKNATQA
Protein: Ribonuclease P protein subunit p14 (O95059)
Organism: Homo sapiens (Human)
Function: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10444065, ECO:0000305}.
Interaction partners:
- Ribonuclease P protein subunit p30
- Ribonuclease P protein subunit p29
- Ribonuclease P protein subunit p21
- Ribonucleases P/MRP protein subunit POP1
- Ribonuclease P/MRP protein subunit POP5
- Ribonuclease P protein subunit p40
- Ribonuclease P protein subunit p25
- Ribonuclease P protein subunit p20
- Ribonuclease P protein subunit p38
- Polyribonucleotide 5'-hydroxyl-kinase Clp1
Sequence:
MPAPAATYERVVYKNPSEYHYMKVCLEFQDCGVGLNAAQFKQLLISAVKDLFGEVDAALPLDILTYEEKTLSAILRICSSGLVKLWSSLTLLGSYKGKKCAFRVIQVSPFLLALSGNSRELVLD
Protein: Pleckstrin homology-like domain family A member 2 (Imprinted in placenta and liver protein) (Protein 50C15) (O08969)
Organism: Mus musculus (Mouse)
Function: Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12374806}. Membrane {ECO:0000269|PubMed:12374806}; Peripheral membrane protein {ECO:0000269|PubMed:12374806}.
Interaction partners:
- Solute carrier family 22 member 18
- Oxysterol-binding protein-related protein 5
- U5 small nuclear ribonucleoprotein TSSC4
- Cyclin-dependent kinase inhibitor 1C
- Potassium voltage-gated channel subfamily KQT member 1
- Achaete-scute homolog 2
- Insulin-like growth factor 2
- Nucleosome assembly protein 1-like 4
Sequence:
MASKIVMSSKTVKTSDEILCEGELEKRSDSLFQVWKKKRCVLTADRLRLFSGKTSPAKELFFHSILKVDCVEHTSKYVYFTIVTNYYKEIDFRCTVESCWNAAITMALIDFQNRRALQDFPRYRYQRSESEMPSEPGEQSALGP
Protein: Ductus ejaculatorius peptide 99B (P81160)
Organism: Drosophila melanogaster (Fruit fly)
Function: Induces post-mating responses; increased oviposition and reduced receptivity.
Subcellular location: Secreted {ECO:0000269|PubMed:11846801}.
Interaction partners:
- Accessory gland-specific peptide 70A
- trypsin
- Odorant binding protein c
- Accessory gland protein 98AB
- Ejaculatory bulb-specific protein 2
- Accessory gland-specific peptide 26Aa
- ACP53C14B
- Prolyl 4-hydroxylase alpha subunit domain-containing protein
- Serpin 77Bb
Sequence:
MKTPLFLLLVVLASLLGLALSQDRNDTEWIQSQKDREKWCRLNLGPYLGGRCRK
Protein: Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (Phosphotransferase system, enzyme I) (Q74KD4)
Organism: Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR000732}.
Interaction partners:
Sequence:
MSKTLKGIAASDGIAVAPAYLLVEPDLSFSKTSVSDVDAEVARFKKVVEESTKELEKVRDKAKESLGPEEAQVFDAHLLFLSDPEFTGAIETEIKDQKINAEAALDETAQKFITIFEGMTDNAYMQERAADVRDVSKRLMAHLLGKKLPDPAAIDHEVVVVAYDLTPSDTAQLNKKYVKGFVTDVGGRTAHSAIMARSLEIPAVVGTETITKDVKDGDMLIADGLDGDAIINPTDAQIEEYTKKGEAFAKQKEEWKKLKNEPSVTANGKKFIIAANIGTPNDMKGVKENGAEAIGLYRTEFLYMDSKDFPSEEAQFDAYKKVIEDMDGKQTIIRTCDIGGDKHLDYWDLPEEMNPFLGVRAIRLSMQYKDIFRTQLRALLRASAYGPLGIMFPMIGTLAELREAKQILAEEKDKLAKEGVKIGDDLQVGMMIEVPAAAVLADQFAKEVDFFSIGTNDLIQYTMAADRGNDNVSYLYQPYNPSVLRLIKHTIDGAHENGIWCGMCGEAAGDDIMFPILLSMGLDEYSMSATSILRIRSLMKKINTEDIKELANKACFVSETADENKKLVEETMKKLNILD
Protein: MMS19 nucleotide excision repair protein homolog (MET18 homolog) (MMS19-like protein) (Q9D071)
Organism: Mus musculus (Mouse)
Function: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96T76}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q96T76}.
Interaction partners:
- Cytosolic iron-sulfur assembly component 2B
- Probable cytosolic iron-sulfur protein assembly protein CIAO1
- General transcription and DNA repair factor IIH helicase subunit XPD
- Cytosolic iron-sulfur assembly component 3
- ADP/ATP translocase 2
- Cytosolic iron-sulfur assembly component 2A
- Regulator of telomere elongation helicase 1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- DNA replication ATP-dependent helicase/nuclease DNA2
- Fanconi anemia group J protein homolog
Sequence:
MAAATGLEEAVAPMGALCGLVQDFVMGQQEGPADQVAADVKSGGYTVLQVVEALGSSLENAEPRTRARGAQLLSQVLLQCHSLLSEKEVVHLILFYENRLKDHHLVVPSVLQGLRALSMSVALPPGLAVSVLKAIFQEVHVQSLLQVDRHTVFSIITNFMRSREEELKGLGADFTFGFIQVMDGEKDPRNLLLAFRIVHDLISKDYSLGPFVEELFEVTSCYFPIDFTPPPNDPYGIQREDLILSLRAVLASTPRFAEFLLPLLIEKVDSEILSAKLDSLQTLNACCAVYGQKELKDFLPSLWASIRREVFQTASERVEAEGLAALHSLTACLSCSVLRADAEDLLGSFLSNILQDCRHHLCEPDMKLVWPSAKLLQAAAGASARACEHLTSNVLPLLLEQFHKHSQSNQRRTILEMILGFLKLQQKWSYEDRDERPLSSFKDQLCSLVFMALTDPSTQLQLVGIRTLTVLGAQPGLLSAEDLELAVGHLYRLTFLEEDSQSCRVAALEASGTLATLYPGAFSRHLLPKLAEELHKGESDVARADGPTKCSRHFRCLQALSAVSTHPSIVKETLPLLLQHLCQANKGNMVTESSEVVAVCQSLQQVAEKCQQDPESYWYFHKTAVPCLFALAVQASMPEKESSVLRKVLLEDEVLAALASVIGTATTHLSPELAAQSVTCIVPLFLDGNTSFLPENSFPDQFQPFQDGSSGQRRLVALLTAFVCSLPRNVEIPQLNRLMRELLKQSCGHSCPFSSTAATKCFAGLLNKQPPGQQLEEFLQLAVGTVEAGLASESSRDQAFTLLLWVTKALVLRYHPLSACLTTRLMGLLSDPELGCAAADGFSLLMSDCTDVLTRAGHADVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLSTLSCLQPLLLEAPQIMSLHVDTLVTKFLNLSSSYSMAVRIAALQCMHALTRLPTSVLLPYKSQVIRALAKPLDDKKRLVRKEAVSARGEWFLLGSPGS
Protein: Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) (P46734)
Organism: Homo sapiens (Human)
Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
Interaction partners:
- Mitogen-activated protein kinase 14
- Dual specificity mitogen-activated protein kinase kinase 6
- Mitogen-activated protein kinase kinase kinase 5
- Serine/threonine-protein kinase TAO2
- Mitogen-activated protein kinase kinase kinase 4
- Mitogen-activated protein kinase 3
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 11
- Cerebral cavernous malformations 2 protein
Sequence:
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
Protein: Calsyntenin-3 (Cst-3) (Alcadein-beta) (Q99JH7)
Organism: Mus musculus (Mouse)
Function: May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:12498782, ECO:0000269|PubMed:24613359}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12498782}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12498782}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:12498782}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000269|PubMed:12498782}.; SUBCELLULAR LOCATION: [Isoform CLSTN3beta]: Lipid droplet {ECO:0000269|PubMed:36477540}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:31043739, ECO:0000269|PubMed:36477540}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum-lipid droplet contact sites through the partitioning of its N-terminal hydrophobic hairpins onto lipid droplets while its C-terminal transmembrane domain remains anchored in the endoplasmic reticulum. {ECO:0000269|PubMed:36477540}.
Interaction partners:
- Leucine-rich repeat transmembrane neuronal protein 1
- Neurexin-3
- Neurexin-1
- Neurexin-2
Sequence:
MTLLLVSLLLASLLQISSGNKANKHKPWIEAEYQGIVMENDNTVLLNPPLFALDKDAPLRYAGEICGFRLHGSGVPFEAVILDKATGEGLIRAKEPVDCEAQKEHTFTIQAYDCGEGPDGTNTKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSPQYSQICYYEILTPNTPFLIDNDGNIENTEKLQYSGEKLYKFTVTAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEPLWNIQATIELQTSHVAKGCDRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSVHYSQDSSLIYWFNGTQAVQVPLGGPAGLGSGPQDGFSDHFTLSFWMKHSVTPSKGKKEEETIVCNTVQNEDGYSHYSLTVHGCRIAFLYWPLLESARPVKFLWKLEQVCDDEWHHYALNLEFPTVTLYTDGISFDPALIHDNGLIHPPRREPALMIGACWTEEKNKEKKGGENSTDTASGDPLLIHHYFHGYLAGFSVRSGRLESREVIECLYACREGLDYRDFESLGKGMKVHVNPSQSLLTLEGDDVETFNHALQHVAYMNTLRFATPGVRPLRLTTAVKCFSEESCVSIPEVEGYVVVLQPDAPQILLSGTAHFARPAVDFEGPEGVPLFPDLQITCSISHQVEAKADESWQGTVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLDMASLQQRGLELTNTSAYLTIAGVETITVYEEILRQARYQLRHGAALYARKFRLSCSEMNGRYSSNEFIVEVNVLHSMNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHRNSMVPSAATLIIVVCVGFLVLMVILGLVRIHSLHRRVSGTGGPSGASTDPKDPDLFWDDSALTIIVNPMESYQNQQTCVAGVAGGQQEEEDSSDSEAADSPSSDERRIIESPPHRY
Protein: Death effector domain-containing protein (DEDPro1) (Q9Z1L3)
Organism: Mus musculus (Mouse)
Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 (By similarity). Inhibits DNA transcription in vitro.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli. Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells (By similarity). {ECO:0000250}.
Interaction partners:
- Beclin-1
Sequence:
MAGLKRRASQVWPEERGEQEHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVTLKKRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGSQMCSKRPARGRTTLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP
Protein: Spindle assembly abnormal 4 (Q9VI72)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Spindle assembly abnormal protein 6 homolog
- Anastral spindle 2, isoform A
- Asterless
- Centrosomal protein 135kDa, isoform B
- Serine/threonine-protein kinase PLK4
- Centrosomin
- Pericentrin-like protein, isoform F
- BcDNA.LD24702
- Anastral spindle 1, isoform A
- Centriolar coiled coil protein 110kDa, isoform B
Sequence:
MQEAGESPVGMPLSQEAIAQRLAALSRWQDEQKRLLQERQSNHRVLLGLEQRNMYKMLGLLHQETESHENSVLEEWDEEHSIQMPRLAADPDEHEPEISMADPQPAKPKRPFLRRGEGLKQRFKINPDQLRLENLPRYKFANAHPQFRTPQMKKGILKKQVKSPPNPAPPPAPKPSAQLDDLNEQRFQQMLIGKNACSSTPDLKSSYASSTTASSTSPRVRFVEQKSRAGQTTHADDEASSEASPMTGVCWAKVLDTQSIKPAQIQRRSAQIRVEDDSNVSIFELLEQKATEGNIDMNSSCIRTFMARKDQRRRVADDSDHIVVTQQVRQMRLQPQVDQMLVQELQEGDEEDTEPSSDQTLTMTPIQVGNTKVRVRFSDSNDTHEYSDATSLNDGSNIQLFEQFKSALFQALEQKKKSSPSKESDEPITKDLQEKANLVRTRLEELETEIATFKEQNAQLLRLRQQHELEKAKCTQDHMEAMERVHDEKIQAEIYLHDERMKIEEERRKFEQQMRLQKSNANSKEKKEIAALKQEVEGLQLQLKQKEQAHVSAQARLRAQLRASEKEQRNYRDEIELLRKENKRLEQELVKIGRENNSKMLQEINRNIARLAPKVLPSATMSDILDENGRRTQSLDGTAGKPAKQREAQNRRQSSGSAQVRSRSRSLSRNKKTPYALDESYASSSSVESEEVQPPVTAPKAATPPPAANSSSDFKREITNADGSKDIWYPNGNLKKISADGMNLRMLYFNKDIKETNIREGTVKYYYAETNTWHTSYLDGLEILEFPNGQTEHRRKDGTVEIHFPNNSIKIVDPSDTEKLEEWRYADGTHLVQLRNGDKILNLPNGQKEIHTKLNKRREYPDGTVKLVYPDGSQETRYSNGRVRLKDKDGKLIMDTDYAKY
Protein: Uncharacterized protein YccJ (P0AB14)
Organism: Escherichia coli (strain K12)
Interaction partners:
- NAD
- Uncharacterized protein YqjD
- Protein ElaB
- Uncharacterized protein YgaM
- Uncharacterized protein YdiZ
- Uncharacterized HTH-type transcriptional regulator YiaG
- Inner membrane protein YqjE
- DNA protection during starvation protein
- Protein YqjC
- Uncharacterized protein YcgB
Sequence:
MPTQEAKAHHVGEWASLRNTSPEIAEAIFEVAGYDEKMAEKIWEEGSDEVLVKAFAKTDKDSLFWGEQTIERKNV
Protein: Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC 2.3.2.23) (E2Q-like ubiquitin-conjugating enzyme 1) (A1L167)
Organism: Homo sapiens (Human)
Function: Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.
Subcellular location: Nucleus {ECO:0000269|PubMed:24000165}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 Q2
- Ubiquitin-conjugating enzyme E2 Q1
Sequence:
MKELQDIARLSDRFISVELVDESLFDWNVKLHQVDKDSVLWQDMKETNTEFILLNLTFPDNFPFSPPFMRVLSPRLENGYVLDGGAICMELLTPRGWSSAYTVEAVMRQFAASLVKGQGRICRKAGKSKKSFSRKEAEATFKSLVKTHEKYGWVTPPVSDG
Protein: DUF724 domain-containing protein 5 (AtDUF5) (Q0WNB1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the polar growth of plant cells via transportation of RNAs.
Subcellular location: Nucleus {ECO:0000269|PubMed:19795213}.
Interaction partners:
Sequence:
MREKHYSEDNSRKRKRGELEHNSDLNETVLPSDWTPDPVKNFAADDDDEETKAKDATMVLPFVKKSPVWKIYESMEVFKRVPQSPHFSPLFEAKEDFREGFALGMMVTFSGVLEKVEDLKTDVPIRQLNSLKDSFTELEKHGFTVTAPLSRIAKLLALKDRQLKILEELKVFDKEMKDESSKKHKAEQEFGEMERKILEVKNKVLELQKQEAALEKQKDATYEKICKMESRARDLGVELEDVE
Protein: Neuregulin1 (Pro-neuregulin-1, membrane-bound isoform isoform X6) (A0A1B4Z255)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAEVKAGKEGKSGDKKKDKESVRSNKPDNSPQAEPKLKNLRSVTVEDGKKTVLKCEILAGNPAPNVKWYKNGKELTGKNKPKSIKIKKKKQGKISELLIRKSTEGDAGLYTCEAVNSLGKTNTTANLFIINTATSTTPSAKTSSHVTPCNESEKEYCVNHGKCFTLEVTPGNIRRLCRCPNEFTGDRCQHYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRERNAAAKGPQHPHPPPENLQLVNHYMPTNPVPAHMTDKEAETSLSTNEFTSPTHPSTAITHSSSQCWSNGKAESVVSDSHAVLMKPSAENCQHGTPSHRGRLNATGGVHQLNDYLKNSREAQGSNRDSPYSERYVSAMTTPTRLSPVGLLSPVTPSSPPSEMSAPLSSLATSVPSMLTSPSGEEERPLLFRTPPILRDKSASTQGRKSGHNLRNSAHYNHGLDIPSPPPSPLHIEEEIDCLEQYKSTSVPSSAPHSPSAARTQPSGQAAPEQAVSGSNSESSSSESETEDERVGEDTPFLGLQNPLAAGSLVLDGLEGSRTNPALHLSPQHELQNRLTAVMANQDPIAV
Protein: Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (P97832)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).
Subcellular location: Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). {ECO:0000250}.
Interaction partners:
- Transcription factor GATA-4
- Homeobox protein Nkx-2.5
Sequence:
MNLVGSYAHHHHHHHSHPPHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPTTAVAAAAYGPDARPSQSPGRLEALGGRLPRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQAGDPEAFKAELKKTDGGRESKRKRESPQQHEGLPPALGPSEKRIKGRTGWPQQVWALELNQ