wanglab/gogpt-training-data huggingface dataset:
Protein: Antitoxin MqsA (Q46864)
Organism: Escherichia coli (strain K12)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MqsR mRNA interferase toxin and neutralizes its endoribonuclease activity. Overexpression prevents MqsR-mediated cessation of cell growth and inhibition of cell proliferation. Initially reported to act as a cotranscription factor with MqsA. Following further experiments, the MqsR-MqsA complex does not bind DNA and all reported data are actually due to a small fraction of free MqsA alone binding DNA. Addition of MqsR to a preformed MqsA-promoter DNA complex causes dissociation of the MqsA-DNA complex, probably causing derepression of MqsA-repressed transcripts. MqsA binds to 2 palindromes in the promoter region of the mqsRA operon activating its transcription. Binds to other promoters, inducing mcbR and spy and repressing cspD among others. Binds to and represses the rpoS promoter, the master stress regulator, resulting in decreased cyclic-di-GMP, reduced stress resistance, increased cell motility and decreased biofilm formation; in these experiments 5 TA systems are missing (lacks MazEF, RelEB, ChpB, YoeB-YefM, YafQ-DinJ). An earlier study showed overexpression alone increases biofilm formation, perhaps by repressing cspD; in these experiments the 5 TA systems are present. Represses the csgD promoter. In the presence of stress, when this protein is degraded, the promoters it represses are derepressed, leading to biofilm formation (Probable). This TA system mediates cell growth during bile acid deoxycholate stress by degrading mRNA for probable deoxycholate-binding protein YgiS; bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum.
Interaction partners:
- mRNA interferase toxin MqsR
- Antitoxin DinJ
- mRNA interferase toxin RelE
- mRNA interferase toxin YafQ
- Antitoxin MazE
- Endoribonuclease toxin MazF
- Antitoxin YefM
- Antitoxin RelB
- Toxin YoeB
- mRNA interferase toxin HigB
Sequence:
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKKLSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Protein: Uncharacterized protein Rv2219 (P9WLI1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Octanoyltransferase
- Lipoyl synthase
- Fatty acyl-CoA reductase Rv0547c
- Uncharacterized protein Rv2308
- Uncharacterized protein Rv1414
- Epimerase family protein Rv2216
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
- DUF3039 domain-containing protein
- Uncharacterized HTH-type transcriptional regulator Rv1830
- RNA polymerase-binding protein RbpA
Sequence:
MAKPRNAAESKAAKAQANAARKAAARQRRAQLWQAFTLQRKEDKRLLPYMIGAFLLIVGASVGVGVWAGGFTMFTMIPLGVLLGALVAFVIFGRRAQRTVYRKAEGQTGAAAWALDNLRGKWRVTPGVAATGNLDAVHRVIGRPGVIFVGEGSAARVKPLLAQEKKRTARLVGDVPIYDIIVGNGDGEVPLAKLERHLTRLPANITVKQMDTVESRLAALGSRAGAGVMPKGPLPTTAKMRSVQRTVRRK
Protein: DNA-directed RNA polymerase (EC 2.7.7.6) (Plastid-encoded RNA polymerase subunit alpha) (Q2LIP4)
Organism: Oryza sp. IRGC 81916
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Interaction partners:
Sequence:
RVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGETEGTCITHAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRTASICVKGPRYITAQDIILPPSVEIVDTAQPIANLTEPTDFRIELRIKRDRGYHTEVRKNTQDGSYPIDAVSMPVRNVNYSIFACGNGNAKYEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHTEEEGTRFQENKNRFTSPLLSFQKRLTNLKKNKKRIPLNCIFIDQLELPSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFRMQDGKQIWDTLEKHLPMDLPKNKF
Protein: Structural maintenance of chromosomes protein (Q6DRM9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
Interaction partners:
- Structural maintenance of chromosomes protein.
- Double-strand-break repair protein rad21 homolog A
- Nipped-B-like protein B
- Stromal antigen 1a.
- Extra spindle pole bodies-like 1, separase.
- PDS5 cohesin-associated factor B
- Cohesin subunit SA
- Sister chromatid cohesion protein PDS5 homolog A
- N-acetyltransferase ESCO2
- Double-strand-break repair protein rad21-like protein 1
Sequence:
MGYLKLIEIENFKSYKGRQIIGPFHKFTAIIGPNGSGKSNLMDAISFVLAEKTSNLRVKTLKDLIHGAPVGKPAANRAFVTMVYQQDGGQELSFSRIIIGSSSEYRINNKVVGLSDYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDRCKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEAERYQRLKDEVVRAHVQLQLFKLYHNESEIEKLNRELAHRNKEIDKDRKRMDRVEEELKDKKKELGRMMRDQQMIEKEIKEKDAELNQKRPLYIKAKENTAHKIKKLEAARKSLQNAQKCYKKRKGDMDELDREQGAVEMARQEFEERMEEEAQSQGQDLQLEENQVKAYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKIETEAKIKQKIREIEENQKRIEKLEDYITTSRQSLDEQKRMEEELTEEVEQAKRRIDEINMELNQVMEQLGDARIDRQENSRQQRKAEILESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELRGAKLVIDVIRYEPPQIKKALQYACGNALVCDNVEDARRIAFGGPYRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKDRKEKLTDELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLSLNMQEKSKLESELANFGPRINDIKRIIQSRERDMKDLKDRMNVVEDEVFVEFCKEIGVRNIREFEEEKVKRQNEIAKKRLEFETQKTRLAIQLDYEKNQLKEDQEKVVMWEQTVKKDENEIEKLKKEEQRNMKIIDETMAQLQDLKNQHLTKKSEVNDKNHEMEEIRKKLGGANKELTQLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLRSGTMDDISQEEGNSQAEESLSSSQKTSSTVLAKEALIEIDYNSLSEDLKDSLSDEEIKAEMNTLQQRLNEQQSILQRISAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFHACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKDQSVQNFQAIVISLKEEFYTKADSLIGVYPEQGDCVISKVLTFDLSQYADANPNPNE
Protein: Threonine efflux protein (P0AG38)
Organism: Escherichia coli (strain K12)
Function: Conducts the efflux of threonine.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}.
Interaction partners:
- Homoserine/homoserine lactone efflux protein
- Threonine/homoserine exporter RhtA
- Bifunctional aspartokinase/homoserine dehydrogenase 1
- Peptidyl-lysine N-acetyltransferase YiaC
Sequence:
MLMLFLTVAMVHIVALMSPGPDFFFVSQTAVSRSRKEAMMGVLGITCGVMVWAGIALLGLHLIIEKMAWLHTLIMVGGGLYLCWMGYQMLRGALKKEAVSAPAPQVELAKSGRSFLKGLLTNLANPKAIIYFGSVFSLFVGDNVGTTARWGIFALIIVETLAWFTVVASLFALPQMRRGYQRLAKWIDGFAGALFAGFGIHLIISR
Protein: NAD(P)-binding Rossmann-fold superfamily protein (Putative cinnamoyl-CoA reductase) (Q9ZVQ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Early nodulin-like protein 17
- F-box protein PP2-A13
- F-box protein At1g61340
- Small ribosomal subunit protein eS1z
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS10x
- Small ribosomal subunit protein eS10y
- Small ribosomal subunit protein eS10z
- Small ribosomal subunit protein eS12z
Sequence:
MAKETVCVTGANGFIGSWIIRTLIEKGYTKIHASIYPGSDPTHLLQLPGSDSKIKIFEADLLDSDAISRAIDGCAGVFHVASPCTLDPPVDPEKELVEPAVKGTINVLEAAKRFNVRRVVITSSISALVPNPNWPEKVPVDESSWSDLDFCKSRQKWYPISKTLAEKAAWEFSEKHGTNIVTIHPSTCLGPLLQPNLNASCAVLLQLLQGSTETQEHHWLGVVHVKDVAKGHVMLFETPDASGRFLCTNGIYQFSEFAALVSKLFPEFAVHKFDKETQPGLTSCNDAAKRLIELGLVFTAVEDAVKETVQSLRDKGFL
Protein: Beaten path IV, isoform A (GH12267p) (Q9VCL1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MKYTNDTRIIVFICCLLQGFAVGLRMIKVSIPAYKLRGESAFLECQYELNRTHHTVTGLQSHSDHAHGHNTHAGEFHYPDGDALEDERSSYRSRMRQSQRQHGQRPRQREPIAMRQYQSQQSHQQLPAPPEKSPYGHSVYRGSAASGYLGAAHVGASTHSGSVSVSNGNSNGVPAAYMPDFDRADSFDDSHDREEEEDEDEEEQPEEGEALYAIKWYKDNEEFYRYVPKARPPKTSYRVDGVRVIEELSDASRVLLRGLTLNSTGLYRCEVSAEAPNFSSVQGEGRMDIVFLPRDGPHIRGQQYQYQIGEYLYLNCTSGKSHPASHLQWFVNEQPILDEHYLHKYNDIVHKHGLITSTLGLQLPLEPRHFHEGDMRVKCLASISPVLWKGGKESVLQRRPGIIDNREAMLLGE
Protein: E3 ubiquitin-protein ligase TRIM62 (EC 2.3.2.27) (Tripartite motif-containing protein 62) (Q9BVG3)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways. E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23402750, ECO:0000269|PubMed:26488816}.
Interaction partners:
- Caspase recruitment domain-containing protein 9
- Ubiquitin-conjugating enzyme E2 D2
Sequence:
MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
Protein: Cocaine-and amphetamine-regulated transcript protein-like 1 (Lymphocyte antigen 97, tandem duplicate 3) (Uncharacterized protein ly97.3) (A0A2R8RTX1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Zinc finger Ran-binding domain-containing protein 2
- MAC-inhibitory protein
Sequence:
MMKFLILAVVLMLAVTGGTALDCIRCVPKKAGGACEVTSETCPPEKSACAAAKFSRSPYGHFQKCMAMSDCEMQKRNSYINIKCCQKDFCNTFD
Protein: Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7) (Q12952)
Organism: Homo sapiens (Human)
Function: Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:34633540}.
Interaction partners:
- Zinc finger protein GLI1
- Carbamoyl-phosphate synthase, mitochondrial
Sequence:
MSHLFDPRLPALAASPMLYLYGPERPGLPLAFAPAAALAASGRAETPQKPPYSYIALIAMAIQDAPEQRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLSLNDCFVKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPKPGPGAPEAKRPRAETHQRSAEAQPEAGSGAGGSGPAISRLQAAPAGPSPLLDGPSPPAPLHWPGTASPNEDAGDAAQGAAAVAVGQAARTGDGPGSPLRPASRSSPKSSDKSKSFSIDSILAGKQGQKPPSGDELLGGAKPGPGGRLGASLLAASSSLRPPFNASLMLDPHVQGGFYQLGIPFLSYFPLQVPDTVLHFQ
Protein: Synaptosomal-associated protein (A5PEW5)
Organism: Caenorhabditis elegans
Subcellular location: Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
Interaction partners:
- Syntaxin-1A homolog
- Synaptobrevin-1
- Synaptotagmin-1
- Lethal giant larvae homologue 2 domain-containing protein
- Alpha-soluble NSF attachment protein
- Acetylcholine regulator unc-18
- Ras-related protein Rab-3
- V-SNARE coiled-coil homology domain-containing protein
- Synaptobrevin-like protein 5
- V-SNARE coiled-coil homology domain-containing protein
Sequence:
MSARRGAPGGQRHPRPYAVEPTVDINGLVLPADMSDELKGLNVGIDEKTIESLESTRRMLALCEESKEAGIKTLVMLDDQGEQLERCEGALDTINQDMKEAEDHLKGMEKCCGLCVLPWNKTDDFEKTEFAKAWKKDDDGGVISDQPRITVGDSSMGPQGGYITKITNDAREDEMDENVQQVSTMVGNLRNMAIDMSTEVSNQNRQLDRIHDKAQSNEVRVESANKRAKNLITK
Protein: Seizure protein 6 (SEZ-6) (Brain-specific receptor-like protein C) (BSRP-C) (Q7TSK2)
Organism: Mus musculus (Mouse)
Function: May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Note=Localized on dendrites and in the postsynaptic fraction. Does not appear to be enriched at synapses, at least not in the presynaptic axon terminal.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Synapse. Cell projection, dendrite. Note=Localized on dendrites and in the synaptic and postsynaptic fraction.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}. Cytoplasm.
Interaction partners:
Sequence:
MRPAALLLLPSLLALLAHGLSSEAPITGEGHATGIRETDGELTAAPTPEQSDRGVHFVTTAPTLKLLNHHPLLEEFLQEGLEREEAPQPALPFQPDSPTHFTPSPLPRLTNQDNRPVFTSPTPAVAAAPTQPHSREKPWNLESKPPELSITSSLPPGPSMAVPTLLPEDRPSTTPPSQAWTPTQEGPGDMDRPWVPEVMSKTTGLGVEGTIATSTASGDDEETTTTIITTTVTTVQPPGPCSWNFSGPEGSLDSPTAPSSPSDVGLDCFYYISVYPGYGVEIKVENISLQEGETITVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPLPAGPGTFHFRYQAYLLSCHFPRRPAYGDVTVTSLHPGGSAHFHCATGYQLKGARFLTCLNATQPFWDSQEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPESQRLHLHFEKVSLAEDDDRLIIRNGNNVEAPPVYDSYEVEYLPIEGLLSSGRHFFVEFSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSAPSYPVGTTVEFSCDPGYTLEQGSIIIECVDLHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGSGDVLTFYDGDDLTARVLGQYSGPRGHFKLFTSMADVTIQFQSDPGTSALGYQQGFVIHFFEVPRNDTCPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYVCDQGFVLTGSAILTCHDRQAGSPKWSDRAPKCLLEQFKPCHGLSAPENGARSPEKRLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNGRSLDVAKAPAASSALDAAHLAAAIFLPLVAMVLLVGGVYLYFSRFQGKSPLQLPRTHPRPYNRITVESAFDNPTYETGSLSFAGDERI
Protein: AT5G45410 protein (Zinc finger B-box protein) (Q9FHJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDQECPFAAESIIQKCPFLRNINKPTNLSFSSLSFPIPVQGGKGPIFEDGPGFDSAFKLFHGKDGIVPLSGFADDSEDEAGRRALQFNPLAGKVATISLSAFGPGGPFGFGPFSEKWKKQQKKPKPSKNQQSGDSSKHEAVGDEWLKTGNCPIAKSFRAASKVMPLISKALTLPPGMKYRCPAPIVAARAALSKTALVKSLRPQPLPEKMLAIALMGMAANVPLGVWREHTKKFSPAWFLAVHAAVPFIAMLRKSVLMPKTAMALTIGASILGQVIGSRAERYRLKAVAEKMVPVTAMVSGYNQSPGDSGISGGHCGIGEGVKQVYYNVNIGESAKSTGLCY
Protein: Aspartate aminotransferase (EC 2.6.1.1) (Q8IPY3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- alanine transaminase
- L-lactate dehydrogenase
- Malate dehydrogenase, mitochondrial
- Malate dehydrogenase
- Aspartate aminotransferase, cytoplasmic
- Tyrosine aminotransferase
- Glutamate dehydrogenase, mitochondrial
- 4-hydroxyphenylpyruvate dioxygenase
- Malate dehydrogenase
- Malate dehydrogenase
Sequence:
MSRTIIMTLKDIVHVWSNDPGERMCRANRVSTWFSEVQMGPPDAILGVTEAFKKDTNPKKINLGAGAYRDDNTQPFVLPSVREAEKRVVSRSLDKEYATIIGIPEFYNKAIELALGKGSKRLAAKHNVTAQSISGTGALRIGAAFLAKFWQGNREIYIPSPSWGNHVAIFEHAGLPVNRYRYYDKDTCALDFGGLIEDLKKIPEKSIVLLHACAHNPTGVDPTLEQWREISALVKKRNLYPFIDMAYQGFATGDIDRDAQAVRTFEADGHDFCLAQSFAKNMGLYGERAGAFTVLCSDEEEAARVMSQVKILIRGLYSNPPVHGARIAAEILNNEDLRAQWLKDVKLMADRIIDVRTKLKDNLIKLGSSQNWDHIVNQIGMFCFTGLKPEQVQKLIKDHSVYLTNDGRVSMAGVTSKNVEYLAESIHKVTK
Protein: Cell wall biogenesis protein NCW2 (New cell wall protein 2) (Q05777)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cell wall biogenesis protein that participates in the organization of the beta-glucan assembly. Involved in the mechanism responsible for cell tolerance to polyhexamethylene biguanide (PHMB), an antifungal agent.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10383953, ECO:0000269|PubMed:11016834}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10383953, ECO:0000269|PubMed:11016834}.
Interaction partners:
- Protein PUN1
Sequence:
MKACSILFTTLITLAAAQKDSGSLDGQNSEDSSQKESSNSQEITPTTTKEAQESASTVVSTGKSLVQTSNVVSNTYAVAPSTTVVTTDAQGKTTTQYLWWVAESNSAVSTTSTASVQPTGETSSGITNSASSSTTSTSTDGPVTIVTTTNSLGETYTSTVWWLPSSATTDNTASSSKSSSGSSSKPESSTKVVSTIKSTYTTTSGSTVETLTTTYKSTVNGKVASVMSNSTNGAFAGTHIAYGAGAFAVGALLL
Protein: BLOC-1-related complex subunit 6 C-terminal helix domain-containing protein (F4JNI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDAGAEIDVVRPVEADSAAEISPEQDHEGRSEPSSLNQGEILKTLATVEKDSQAIAESFSSLFVSLRSTLSEATGSSVDHMACFGEAAGRLQENALDAATKGNRYINSCLRLWITYFSYIKILIIKLMMPKNSKLTFRSLSKSLSLFGSSSPARLNLWFLWIGFVSVRTESSTISPLADALEEEALDVDDFEADKKPEDLQPSVVYQQRLLEERKIYENEQQREVERLKSDLKEKKRLARMLDNKEIFRVIRLRQPEFERLRSERSILVK
Protein: Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain] (Q9R098)
Organism: Mus musculus (Mouse)
Function: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.
Subcellular location: Secreted {ECO:0000250}. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. {ECO:0000250}.
Interaction partners:
- Kunitz-type protease inhibitor 1
- Kunitz-type protease inhibitor 2
- Hepatocyte growth factor receptor
- WD repeat-containing protein 90
- Hepatocyte growth factor
- Inactive tyrosine-protein kinase 7
Sequence:
MGRQAWISSLCPLPRPCPFLLLLLLLVVPRGAQPQAGRNHTEPPGPNVTATPVTPTIPVISGNVSTSTESAPAAETEGPQSERYPPPSSSSPPGGQVLTESGQPCRFPFRYGGRMLHSCTSEGSAYRKWCATTHNYDRDRAWGYCAEVTLPVEGPAILDPCASGPCLNGGTCSSTHDHGSYHCSCPLAFTGKDCGTEKCFDETRYEYFEVGDHWARVSEGHVEQCGCMEGQARCEDTHHTACLSSPCLNGGTCHLIVGTGTSVCTCPLGYAGRFCNIVPTEHCFLGNGTEYRGVASTAASGLSCLAWNSDLLYQELHVDSVAAAVLLGLGPHAYCRNPDKDERPWCYVVKDNALSWEYCRLTACESLARVHSQTPEILAALPESAPAVRPTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGNSFCAGSLVHTCWVVSAAHCFANSPPRDSITVVLGQHFFNRTTDVTQTFGIEKYVPYTLYSVFNPNNHDLVLIRLKKKGERCAVRSQFVQPICLPEAGSSFPTGHKCQIAGWGHMDENVSSYSNSLLEALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLVCEKNGVAYLYGIISWGDGCGRLNKPGVYTRVANYVDWINDRIRPPKRPVATS
Protein: Suppressor of tumorigenicity 14 protein homolog (EC 3.4.21.109) (Epithin) (Serine protease 14) (P56677)
Organism: Mus musculus (Mouse)
Function: Degrades extracellular matrix. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Kunitz-type protease inhibitor 1
- Kunitz-type protease inhibitor 2
- Kallikrein c
- Proteinase-activated receptor 2
Sequence:
MGSNRGRKAGGGSQDFGAGLKYNSRLENMNGFEEGVEFLPANNAKKVEKRGPRRWVVLVAVLFSFLLLSLMAGLLVWHFHYRNVRVQKVFNGHLRITNEIFLDAYENSTSTEFISLASQVKEALKLLYNEVPVLGPYHKKSAVTAFSEGSVIAYYWSEFSIPPHLAEEVDRAMAVERVVTLPPRARALKSFVLTSVVAFPIDPRMLQRTQDNSCSFALHAHGAAVTRFTTPGFPNSPYPAHARCQWVLRGDADSVLSLTFRSFDVAPCDEHGSDLVTVYDSLSPMEPHAVVRLCGTFSPSYNLTFLSSQNVFLVTLITNTDRRHPGFEATFFQLPKMSSCGGFLSDTQGTFSSPYYPGHYPPNINCTWNIKVPNNRNVKVRFKLFYLVDPNVPVGSCTKDYVEINGEKYCGERSQFVVSSNSSKITVHFHSDHSYTDTGFLAEYLSYDSNDPCPGMFMCKTGRCIRKELRCDGWADCPDYSDERYCRCNATHQFTCKNQFCKPLFWVCDSVNDCGDGSDEEGCSCPAGSFKCSNGKCLPQSQKCNGKDNCGDGSDEASCDSVNVVSCTKYTYRCQNGLCLSKGNPECDGKTDCSDGSDEKNCDCGLRSFTKQARVVGGTNADEGEWPWQVSLHALGQGHLCGASLISPDWLVSAAHCFQDDKNFKYSDYTMWTAFLGLLDQSKRSASGVQELKLKRIITHPSFNDFTFDYDIALLELEKSVEYSTVVRPICLPDATHVFPAGKAIWVTGWGHTKEGGTGALILQKGEIRVINQTTCEDLMPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSAEKDGRMFQAGVVSWGEGCAQRNKPGVYTRLPVVRDWIKEHTGV
Protein: Sodium-independent sulfate anion transporter (Solute carrier family 26 member 11) (Q86WA9)
Organism: Homo sapiens (Human)
Function: Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12626430}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:20957757}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q80ZD3}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q80ZD3}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- N-sulphoglucosamine sulphohydrolase
Sequence:
MPSSVTALGQARSSGPGMAPSACCCSPAALQRRLPILAWLPSYSLQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVSFYTFHEPAYAVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFLQVYHTFLRIAETRVGDAVLGLVCMLLLLVLKLMRDHVPPVHPEMPPGVRLSRGLVWAATTARNALVVSFAALVAYSFEVTGYQPFILTGETAEGLPPVRIPPFSVTTANGTISFTEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFRTLWRVKRLDLLPLCVTFLLCFWEVQYGILAGALVSLLMLLHSAARPETKVSEGPVLVLQPASGLSFPAMEALREEILSRALEVSPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFVGLQVPVLRVLLSADLKGFQYFSTLEEAEKHLRQEPGTQPYNIREDSILDQKVALLKA
Protein: Ferric reductase transmembrane component 1 (EC 1.16.1.9) (Ferric-chelate reductase 1) (Q04800)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P32791}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Iron transport multicopper oxidase fio1
- Plasma membrane iron permease
- Siderophore iron transporter 1
- Iron-sensing transcriptional repressor
- Vacuolar heme ABC transmembrane exporter abc3
- Siderophore iron transporter 2
Sequence:
MAINSSDKWTVIAICLILGILLAFILMFWLERFRVIIKSNAHKHDPSDKRQIWLEKYYLFVRQIYTYLVTHKVILTLIAVPVVFAISIPFIGMQTPASSHGKQTTQVSTGNWSKNAVAARLGFLACGLYVTSYFFSIKNNPFALLLISSHEKMNYVHRRLSQYAIMIGAIHGFAYIGLAAQGKRALLTARVTIIGYVILGLMVIMIVSSLPFFRRRFYEWFFVLHHMCSIGFLITIWLHHRRCVVYMKVCVAVYVFDRGCRMLRSFLNRSKFDVVLVEDDLIYMKGPRPKKSFFGLPWGAGNHMYINIPSLSYWQIHPFTIASVPSDDFIELFVAVRAGFTKRLAKKVSSKSLSDVSDINISDEKIEKNGDVGIEVMERHSLSQEDLVFESSAAKVSVLMDGPYGPVSNPYKDYSYLFLFAGGVGVSYILPIILDTIKKQSRTVHITFVWSARSSALLNIVHKSLCEAVRYTEMNINIFCHLTNSYPVEEVSSLNSQSARNYSLQYLNGRPDVNDYFKDFLHATGTQTAALASCGSDKLLRHLKSCVNTHSPSTVDLYQHYEEI
Protein: LGL-1 (Lethal giant larvae homologue 2 domain-containing protein) (G5EEI1)
Organism: Caenorhabditis elegans
Interaction partners:
- Partitioning defective protein 6
- Protein kinase C-like 3
- Disks large homolog 1
- Partitioning defective protein 3
- Protein Scribble homolog let-413
Sequence:
MSSILRFIRSKFYHEPEEHAIEQYAVFDEGNRGGFTSDVVAFDYHNGCVVIGSKNGEVTFYGYRGASWTVSLSKDSENKARIEHIFFISSNIALVLCDGQLIIPIHIKDGVITKKEELRFNENHKSKWDITHVQKLSDDTFALVFSMNNTIYRIKSKTLKSEVLVKAEDFEKWLPDDTELASITCLPEKPSILMLIAENGCVGVFNESQFVMKTSLRNYEDEAIQKLHWSSEKKKNVAFGISCNNKYTKWEFTVGKDCQISAQEVNVYSANQFGPYPCHQIRHFSVCADASDPNENFLIYQGGKSSGKYDDRDLITISHGDFVEKLELSSEIVGIVGVSGSYEDCKKSGVVLICTKCEIIGIDLERESLNMMQPKHFLSINNSTPTTHSRAIEIEENVWNRLESASKSYWETNQMSTRDWPLNFQKKIVTDANHQRASYRQVYLSGHSNGNICIWSSGGVGMSLMLVIRTSLEFDGASSFDNEDSNYYNSDEKPEKPVRKIGLYDPFDDDEEMCITRVHFDPKSGIVIGTNRGGYVLMYELWDSARTLTHWEATPISCNNSPPDTRKRALKPRKAELKYNAGYQIRLKNESDLPLVFSMHPSHRITDIVYLHKYHCLAVGSNFGIVMLDVNFGYLVYANSFNDDNNDSSNVSANQFQRFKSLKKSLRKTFRRKKKGTETLMDSGGAVASSSNHVQHETSPKRIDDFEEEEVFMERPIEAREELGVLDCYAENSKGTVTCLRMMRFPVLDDKNVDDIIAVGLHEGSVYFYAISEHDVGLRMTFKAEQIKKLSIPHKQPVVNLDITNEEGYFSASTRIVVITEEQLRIYNCQPMVKRDSYKITALEGLKIKNGMVARILNKKNSNNFESFVVLVANDGSLRVHSVQKASSFESRKFIDPIDVMALNSSCLSRDGDVAFLIKSSELQRSTVNLNFRGWSSTHKS
Protein: Carnitine O-palmitoyltransferase 1, muscle isoform (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (Carnitine palmitoyltransferase 1B) (F6P7Z9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004374}.
Interaction partners:
- Acetyl-CoA carboxylase beta.
- Carnitine O-palmitoyltransferase 2, mitochondrial
- long-chain-fatty-acid--CoA ligase
- Long-chain-fatty-acid--CoA ligase ACSBG1
- Acyl-CoA synthetase long chain family member 4a.
Sequence:
MAEAHQAVAFQFTVTPDGIDLQLSREVLKHIYISGVTSWKKRAIRFKNSVLTGVYPASPSSWLFVVIAIMSTMYARIDPSMGTIDKIKTSLPVSEFMTVQTQTVLSAILFATGLWLSVIFLLRYLLKALLSYHAWIFESHGKMSYSTKVWLSLVKLLSGRRPLLYSFQGSLPHLPVPSIDDTIRRYLESVRPLLDDEQYKQMETVANDFKKDPAPKLQKHLKLKSWWATNYVSDWWEEYIYLRGRDPIMVNSNFYTMDLLYVIPTYRQAARAGNVVHAMLQYRRKLERGELTPLRALGIVPMCSFQYERMFNTTRIPGIETDFVQHLKDRKHLVVYHRGRLFKVWLYYGGRHLWPSELELQFQRILDDKSEPQPGELKLPSLTAGNRVPWARARLKYFGEGVNRASLEAIETAAFFLTLDDEAHGYDPENIRSLDLYAKSLLHGKCYDRWFDKSFNLIVYKNGKMGVNTEHSWADSPIIGHMWEYVLATDCFHLGYTAEGHCKGDVNKTLAPPTRLQWDIPKACQEIIEGSYRIAKGIADDVDFHGCLFNEFGKGLIKKCRTSPDAFIQLALQLAQYRDKGEFCLTYESSMTRMFREGRTETVRSCTCESTAFVRAMEDDTTTNEQRLALFKQAAEKHQNMYRLAMTGAGIDRHLFCLYIVSKVMGIDSPFLKQVLSEPWRLSTSQTPQQQLNLIDTQKFPKYVSAGGGFGPVADDGYGVSYIIVGENLITFHISSKFSSPETDSFRFGQNIRQAMQDIRALFNQKEKKM