wanglab/gogpt-training-data huggingface dataset:
Protein: Brix domain-containing protein (O44991)
Organism: Caenorhabditis elegans
Interaction partners:
- RRP15-like protein
- Ribosome biogenesis protein BOP1 homolog
- Ribosomal L1 domain-containing protein
- Ribosomal RNA processing protein 1 homolog
- Probable rRNA-processing protein EBP2 homolog
- Nucleolar complex protein 2 homolog
- SURF6 homolog gldi-11
- WD repeat-containing protein 74
- Pescadillo homolog
- RNA helicase
Sequence:
MKMKKGKKQRKSGAHNRGNVDALSQKDALYHQEKFVKKLQKQKFLENKEIELARQPHCLVIHRGDVGKYVKGLESDLRNLVEPNTAKNLKILKRNNIKDFIVNGAVLGVTNMMVLTSSDASLQLRMMRFSQGPTLSFKVKQYSLARHVVNCQKRPVATDKLFKSSPLVVMNGFGDGTQKHLSLVQTFIQNMFPSINVDTIQLGNLKRCLIVSYDEETDEIQMRHFAIRVVASGLNKSVKKLMQAEKTMGKNIPNLSTYKDISDYFLNPGQLSDSEFEGDQQEVELPQDISEGRGCGVGQKSNVRLHEIGPRLTLELVKIEEGIDEGEVLYHKHNAKTPDELIKLRAHMDKKKQMKKRREQESEQRVIRRLTIVKEQQDAEEAEVKAIRENAARKQAAATGQVEEVENQKEKDREIAMNRERDLKRANEEWGTSEASKRPRYEDSRGGFRGGFRGRGEDRGGFRGRGGDRGGFRGRDRDGGGFRGRSVDRGGFRGGGGDRGGFRGRSSDRGGDRGGFRGRSGDRDGGFRGGFGGRGGGGFRGGDRGGFRGRGGGGGFRGGRGGDRGGGFRGGRR
Protein: ATPase H+-transporting accessory protein 1b (V-type proton ATPase subunit S1b) (A2AR67)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Renin receptor
- V-type proton ATPase subunit d 1
- V-type proton ATPase 21 kDa proteolipid subunit c''
- V-type proton ATPase subunit H
- V-type proton ATPase subunit G
- V-type proton ATPase proteolipid subunit
- V-type proton ATPase subunit F
- V-type proton ATPase subunit C 1-A
- Vacuolar proton pump subunit B
- V-type proton ATPase subunit D
Sequence:
MTEVGMRRCSLLTMAFTSVLLFICSIYSCYAQVPLLMWTSDGSSMPHLAEAAAGHTVSGGQLVSYLRSALSTAPHNVLIFLQDQLSIEDFTMYGGVFGNKQDSAFLNIESALQTSSSPLVLSALDWTASHSVLDLFQKELSVSAVHIDTNTLNEMKLNNTQPSLLAVRLLYTAGSQSKEMLLKNDMIIGEVLDMFKSQDMPYTAVYTGLKPSRIIEDTPVMAGFSMGRSLLQTPPPQSEKPPLVFNDTAGQPCIMLWADTLLAAYDGNQADLASNIFNSTPDTTGSFCNETVSRLVLNYRNILNLQSLQLIFSMSKIFFPVSARNWTVMDQVVLEYDGQRAMFNASAGINTPAEYSFRCQNVSSAQSPLLVPRNATDNATKWTLIFTDFQIQSFSVTGDSFAFASDCAGFFSAGIWMGLVISLLMLLILTYGLHMIMQLRTMDRFDDPKGPAISVPLSE
Protein: Didemethylasterriquinone D synthetase tdiA (EC 2.3.1.-) (Nonribosomal peptide synthase tdiA) (Terrequinone biosynthesis protein A) (A7XRY0)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Didemethylasterriquinone D synthetase; part of the gene cluster that mediates the biosynthesis of terrequinone A, an antitumor agent. The first step in the biosynthetic pathway for terrequinone A is formation of indole pyruvic acid (IPA) from L-tryptophan by the aminotransferase tdiD. The nonribosomal peptide synthase tdiA then immediately converts unstable IPA to didemethylasterriquinone D (DDAQ D), via condensation of 2 IPA molecules. The symmetric connectivity of the 2 IPA molecules is thought to arise by head-to-tail dual Claisen condensations facilitated by the TE domain. TdiB then catalyzes reverse prenylation by transferring dimethylallyl diphosphate to carbon atom 2' of DDAQ D, to yield asterriquinone C-1. Finally, tdiC and tdiE enzymes robustly convert asterriquinone C-1 to terrequinone A via a transformation involving regular prenylation at carbon atom 5, which requires elimination of the hydroxy group on C-5.
Interaction partners:
- Indole prenyltransferase tdiB
- Aminotransferase tdiD
- Nucleoporin NSP1
Sequence:
MAPSKTEIAPLRAAKYPFGNIVDALRHAAAHTDEGIIVYHPNSISTSSPPQTVSYKDLLHQAEANATRLLQQKLCSPKSIVLVHFESALDSIVWYWSVLLAGGIPALTGPGMFSQNPADRERHLRHLSETLNSPVCLTRPALLAPFEEQTADDRIKARTVDEILAAPEIADVADAPLPALTPSSTDMLALMLTSGSSGNAKAVPLTHQQLLAAFRGKSTAASLRFPRSPFLSWVHMDHVANLVHCHIFAIVSGISQIQVPAPDLLINPAQLLNLISRHRVSRTFMPNFLCAKLRRQLESGSPEYILDPGLNLETLYIDTGGEANVTEVCIALQSLLSRYGAPDNVFKPSFGMTETVAGCIFNSHCPSYDHAQRHEFACLGKPMPGVRMRVTRLDTPSEEAAPGERGSLEVTGEVVFKGYYNNPAATAEAFTSDGWFRTGDLAFIDSNGNLHLDGRTKEMININGVKYLPYELDAALEQAQIPGATPSYFCTFSSRDATMDTEVVVVLYLPSYVESDDEARFSTQSSIIRVVAMHTRSRPRVVPLRPQDMPKSTLGKLSRAKLKTALEEGQFATQQQINDEAIRRYQQKTRASPETPDEAVILDIIKEQLEIRSDDDSFGVNDSILSIGATSMDLVAIIHRINKCLQPSQPLRLTDILKDSTARGLAVALATGAAPRSQDQSSTHVYDPVVTLQPHGTKSPLWLVHPGVGEVLVFVNLAHHITDRPVYAFRAKGFNAAAGLPETPFTSLEELFTTYRDAIKERQPHGPYAIAGYSFGGMVAFEVSKLLEQDGDEVRYCGSWNLPPHIKFRMRELVWEECVIHLFYFVGLMTELAAYTHKPTLQEFNRANRRLDAIRYLRQHCDAARWDELGLSEEYYLLWVGLASNMQSLAVDYEPSGSVKCMDVFVADPLSHVAKDRIDWVEGRLSAWKEFVREDVRFHDVQGAHYTMLNREYVEAFAGTLKNVLRERGL
Protein: Plexin-B3 (Plexin-6) (Q9QY40)
Organism: Mus musculus (Mouse)
Function: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 (By similarity). Seem to be non-essential for normal development and function of the central nervous system.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Colocalizes with RIT2/RIN at the plasma membrane. {ECO:0000250}.
Interaction partners:
- Semaphorin-5A
- Semaphorin-4D
- Semaphorin-4C
- Rho-related GTP-binding protein Rho6
- Semaphorin-4A
- Semaphorin-4F
- Rho guanine nucleotide exchange factor 12
- Semaphorin-4G
- Hepatocyte growth factor receptor
- Semaphorin-4B
Sequence:
MLTDFLQAPVMAPWSPFSLHLLLLFLPLLPLTRVHRFSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRTQELVACGQVKQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPLPGRDLLLVARGLAGKLSAGVPPLTVRQLAGPQPFSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLRDVNLYSYVEMPLTCHGQGLIQAAFLTPDTLLGAFSAGTSQAQAALCAFPLADLDRSMEQARRLCYTTGGQGPSGMEEATVEYGVTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQSISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHGQVYHSQQVGPPGSAISPDLLVDSNGDHLYVLTAQQVDRILVAACPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGRAAQPNHWLWSYEDNHCPYIQSLLPAQHPRQEQGQIILSVPRLPTLAMDEYFHCAFGGYNSLAQVEEPHVVCTTPPQDQMPPNPPGSDHVTLPLALMFEDVVLTATTFSFYDCSAVQALEVAAPCRACVSSLWRCHWCPQSSHCIYGEHCPEGEKAVYSAQEVDILVRGPEACPQVEGLASPQLVPVGWESHVTLHIQNLHYFQGLPALYHCWLELPGKLQKLPASLEETSRDSGLIHCQAQQFYPSMSQWELPVPIYVTRGEIQRLDNAGDLHVTLYDCAMGHPDCSHCQAANGSLSCLWCGDGQPACRYGPLCPPGAVEQLCPIPSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPAPNGTAGPVQVAIKSRPPGISTQNFTYQDPVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNISVFVGDQPCPIQEPVCPEAIICHTMPQTEPGEAVVLIVFGHVERKLLTTPFRYTANPQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLSVWLEDEPKVKALGVQAQDANPRRSCGAPAADPQACIHLESGLLQCSTLCSVNSSSLLLCHSPAVPDGALPKRVFFALDNMQVDFASASGGQGFLYQPNPRLAPLSHEGITHPYHLKPGHVLDVEGEGLNLGISKEEVQVHIGDGECLVKTLTLTHLYCEPPPQAPQPTNGSGTLPQFVVQMGNLRLALGPVQYEAESMMSTFPVEAQLGLGMGAAVLIAAVLLLTLMYRHKSKKALRDYQKVLVQLENLETGVGDQCRKEFTDLMTEMTDLTSDLEASGIPFLDYRTYAERAFFPGHVGCPLQPGLEGLGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASLLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQVDKGPVDAVTGKAKRTLNDSHLLREDVEFQPLTLMALVGPEADRAAGNSGVHRVPARVLDTDTITQVKEKVLDQIYKGTPFSQRPSVHSLDLEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDGATVVLIPQVHNGGTVSQSLGQTGCPSGENTPMLEDGEEGGVRLWHLVKATEEAEGAKVRRSSLRDRERERSRAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSMNRPVPIAVKYLFDFLDELAEKHGIEDPETLHIWKTNSLLLRFWVNVLKNPQLIFDVQVSDNEDAILAVIAQTFIDSCMVSEHKVGRDSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALAELSGNYSSAPHCLEALRELYNHIHRYYDQIISALEEDPVAQKMQLACRLQQVAALVEYKVTDL
Protein: Granulin-A (Q8QGN9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MLRLTVCLAVVTLVICSQCPDNEVCEAGQSCCQDPTGGFSCCPFHHGECCEDHLHCCPEGMLCSVKDLTCTNATHTEPLADRTQAKKPDLPKSFRMIFSMPASESDISCPDGSSCPAEFSCLLMSTSYGCCPVAQGLACSDGKHCCPNDHECSSDSSLCVKRKVKVETVLCGNGTSECPADTTCCQAEDGLWGCCPMPKAVCCDDKIHCCPEDTVCDVKALKCISSTNQELPMWDKFPARLRAEWEDHKQKKPETQRTTTRPTGTTSTNTAANQMTTLPAEHQAVSSDVPCNDTAACADGTTCCKTKDGGWACCPLPEAVCCEDFIHCCPHGKKCDVAAGSCDDPSGSVPWVEKVPVRPIKKQKVAVTQVSSLSSDVPCNDTAACADGTTCCKTKDGDWACCPLPEAVCCEDFVHCCPKGKKCNIAAMKCEDPSCTGEPLVKQTPVQSTTTPNVIGKQKSNVPCNDTAACADGTTCCKTKDGDWACCPLPEAVCCEDFIHCCPHGKKCDLAAGSCDDPSGSVPWVEKVPVRPIKKQKVAVTKVSSVSSDVPCNDTAACADGTTCCKTKEGGWACCPLPEAVCCEDFIHCCPHGKKCNVAAGSCDDPSGSVPWVEKVPVHLRAGQRSSGKVKCNATHGCPESSTCCKNIAGEWGCCPFSQAVCCTDGEHCCPAHYKCNLSSVSCIKGDVVIPWYNKIAAESTPAPKLDLGVVKCDEQSSCSADSTCCLLSKEETGCCPFPEAVCCPDQKHCCPEGYRCDLRRRSCVKTTRLYVEITQLTHIRSNKPQPSVIVKDVQCGGGFSCHDGETCCPTSQTTWGCCPSPKAVCCDDMQHCCPAGYKCGPGGTCISAGDLDWSNWVNWKLFFSKKKRALTL
Protein: High-affinity branched-chain amino acid transport system permease protein BraE (P21628)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein
- High-affinity branched-chain amino acid transport system permease protein BraD
- High-affinity branched-chain amino acid transport ATP-binding protein BraF
- High-affinity branched-chain amino acid transport ATP-binding protein BraG
- Branched chain amino acid ABC transporter ATP binding protein
- High-affinity branched-chain amino acid transport ATP-binding protein
- Amino acid binding protein
- Branched chain amino acid ABC transporter membrane protein
- Aliphatic amidase expression-regulating protein
- Probable permease of ABC branched-chain amino acid transporter
Sequence:
MSQSLKRALFSALLVILVSYPILGLKLRTVGIKLEVLGADAQTLWTIAAAALAMFVWQLFRDRIPLKLGRGVGYKVNGSGLKNFLSLPSTQRWAVLALVVVAFVWPFFASRGAVDIATLILIYVMLGIGLNIVVGLAGLLDLGYVGFYAVGAYTYALLAEYAGFGFWTALPIAGMMAALFGFLLGFPVLRLRGDYLAIVTLGFGEIIRILLRNMTEITGGPNGIGSIPKPTLFGLTFERRAPEGMQTFHEFFGIAYNTNYKVILLYVVALLLVLLALFVINRLMRMPIGRAWEALREDEVACRALGLNPTIVKLSAFTIGASFAGFAGSFFAARQGLVTPESFTFIESAMILAIVVLGGMGSQLGVILAAVVMVLLQEMRGFNEYRMLIFGLTMIVMMIWRPQGLLPMQRPHLELKP
Protein: Krueppel-like factor 15 (Kidney-enriched krueppel-like factor) (Q9UIH9)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:10982849, ECO:0000269|PubMed:17438289}.
Interaction partners:
- Cilia- and flagella-associated protein 100
- Transmembrane and coiled-coil domains protein 1
- Podocalyxin-like protein 2
- Basic helix-loop-helix ARNT-like protein 1
- Chloride channel protein ClC-Ka
- Plexin-D1
- Chloride channel protein ClC-Kb
- Myocyte-specific enhancer factor 2A
- Histone acetyltransferase p300
Sequence:
MVDHLLPVDENFSSPKCPVGYLGDRLVGRRAYHMLPSPVSEDDSDASSPCSCSSPDSQALCSCYGGGLGTESQDSILDFLLSQATLGSGGGSGSSIGASSGPVAWGPWRRAAAPVKGEHFCLPEFPLGDPDDVPRPFQPTLEEIEEFLEENMEPGVKEVPEGNSKDLDACSQLSAGPHKSHLHPGSSGRERCSPPPGGASAGGAQGPGGGPTPDGPIPVLLQIQPVPVKQESGTGPASPGQAPENVKVAQLLVNIQGQTFALVPQVVPSSNLNLPSKFVRIAPVPIAAKPVGSGPLGPGPAGLLMGQKFPKNPAAELIKMHKCTFPGCSKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHIKVHRFPRSSRSVRSVN
Protein: At3g54390 (Sequence-specific DNA binding transcription factor) (Q9M2U8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MENGESNQENLKSLNHDESLKKPSASSVVVDRLKRDEWSEGAVSTLLEAYESKWVLRNRAKLKGQDWEDVAKHVSSRATHTKSPKTQTQCKNKIESMKKRYRSESATADGSSWPLYPRLDHLLRGTQPQPQPQAVLPLNCSVPLLLLEPPLPAVAHPPQISYGSNGVGKIPKEDGFKPENKPEKDAEMDTDSSTPVVKTKVRGKKVKRRYKEEKEEIAGSIRWLAEVVMRSERARMETMKEIERMRAEAEAKRGELDLKRTEIMANTQLEIARIFAAAASSGQNKGVDSSLRIGRN
Protein: Protein CHLORORESPIRATORY REDUCTION 42, chloroplastic (F4K6X0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain. Functions in assembly or stabilization of the NDH complex; probably involved, together with CRR1 and CRR6, in the incorporation of NdhJ, NdhM, NdhK and NdhI into the NDH subcomplex A assembly intermediate (NAI500) to produce the complex NAI400.
Subcellular location: Plastid, chloroplast {ECO:0000255}. Plastid, chloroplast stroma {ECO:0000269|PubMed:22274627}.
Interaction partners:
- Protein CHLORORESPIRATORY REDUCTION 7
- Protein CHLORORESPIRATORY REDUCTION 6
- At1g78995
- Histone chaperone ASF1B
- Probable histone chaperone ASF1A
- NAD
- NAD
- Protein CHLORORESPIRATORY REDUCTION 41
- NAD
- Alanine--tRNA ligase, chloroplastic/mitochondrial
Sequence:
MALSFVSSTRFSKMQYGIWHSGSFTQRVSVRCCEIANEAPRPKSKLQVGSPIIIVEAPKVIKTAASMPCLRANSGLVKPGDVGRIVSRKPKDLWAVRLSIGTYLLDGKYFKALELDEGDSD
Protein: Rhoptry neck protein 5 (C0H4V4)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Gametocyte-specific protein
Sequence:
MLKYTLLIYIIAGYFISEISNKLFDTLLPRNVFKKPKPFKKNEIKKGIDKDEKSIMKNVDSIDVMFEPRVKRFVPSRTRKTHVVGGLSQSIPDPGDVEKSKYEKAVRFFENIKNEMINMSSKINKQLDSQDISSLNNFKRASEVLKESLATMHSLDIIRNDGSVDFSKYTLDWYSKANMREKYSIEKSIQKIMNKLFKKARKKKKNMKKKKIDANIEQLEMDLLVQKFITENLNASKLLKLYDDSANDYVSPMHTDVCGQLGSIIFSYMFEKAYKSSINHDISYFQKYLPRLKYRIQNMIQKGTLLLLEKGLDDSLYTFKSKISDIMEKKFGFNDMCTDKCMDETIKADYDLSEYKNEFSPSKTAQRRADLVKLLMYYYRDKIYNIETSADVVLIMLLYLNSANELSEKGYLDVSSISTDDEFNLINKTIDRSHKFNKKIKIKKKTFFKIAPFNFFREETQEKTGNESIFAIDDIIKTSLLAKKSQNYNSLYETTKDLWNQIQNMYSASYGFVQSKKIKTNKFVGSKIRNVGFLLRWFNYNKTPSKNINFLVNNFSPLVSISLQLVFFITTMIEQYESSFLGNFSSALKKIFTLGKSGRNPRNYNDLVNFSEVDYLLRTSKANNVQRIIMQIIRMLKKKFLSSSYTPTLLAQYMSIFLSLWVFEGENNISLQNPNISRFKKIFFLTYFVHEKGPVEKAVDIIYNKCRMKTDKIVLGCIHDYGGREKKKLLGLISRKCKPTKISIRKRSIRKILNKLMSSLNDPVDILRIAVDTATRCDHFNRSKNIDNVKTKKNKINYEIFVKSELSIRYICADVTKNVVKKIIRDVSRLKNMREAQNVIDNGLNSVQYLKIRNYRDKESSFTILCPFMEGNDKNIRELERTQISLFIHKNIGMSRIIKGKLINIFKKTLNMREGIKSDSAISIKVGARKYNGIIFTGGYQLNVDNLDQNTLHIGLSKTRKVYDGRKYVDELEILKGDGVKNIYMKGLNEDNERIYELQNNMRVSEFDYAIQNPEANIIVFDGNNYISSYALRNMGLEHERIVWAGPSVGWTAEFALSAISDNPLPIFDGSAWVLLEKLSIRSILGKHLPSDVNGNSLANTVNFVILNKDGKPILKNTTPVINLKYATFTLSGIVNFVIKAEKGIGNEIIVHTRIP
Protein: Regucalcin homologue (Regucalcin, isoform A (EC 3.1.1.17)) (Regucalcin, isoform B) (Regucalcin, isoform C) (SD03837p) (Q9VYR1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSYKVEPLPDSYAGLGEGPHWDVARQSLYYVDLEAGSLLRYDYAQNKVYKTKIEGETLAGFVLPVEGRPQEFAVGCGRRVVIVNWDGVSPSAKVVRTLFEVQPLMEKNRLNDAKVDPRGRFFGGTMRYIGDEFEFRHGELYRWEAGGQVSVIKGDVGISNGLAWDEKAKKFYYIDTTDYEVKSYDYDFETGVASNPKVIFNLRKNSPKDHLLPDGLTIDTEGNLYVATFNGATIYKVNPNTGKILLEIKFPTKQITSAAFGGPNLDILYVTTAAKFDQPAPAGTTYKVTGLNATGYPGVNLKV
Protein: Peptidoglycan recognition protein 3 (Peptidoglycan recognition protein I-alpha) (PGLYRPIalpha) (PGRP-I-alpha) (Peptidoglycan recognition protein intermediate alpha) (Q96LB9)
Organism: Homo sapiens (Human)
Function: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
Subcellular location: Secreted {ECO:0000269|PubMed:16354652}.
Interaction partners:
- Peptidoglycan recognition protein 4
- Late cornified envelope protein 3B
- Late cornified envelope protein 1A
- Late cornified envelope protein 3C
Sequence:
MGTLPWLLAFFILGLQAWDTPTIVSRKEWGARPLACRALLTLPVAYIITDQLPGMQCQQQSVCSQMLRGLQSHSVYTIGWCDVAYNFLVGDDGRVYEGVGWNIQGLHTQGYNNISLGIAFFGNKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLLKEETCLDPQHPVMPRKVCPNIIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDIGYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQCAVVEGYLTPNYLLMGHSDVVNILSPGQALYNIISTWPHFKH
Protein: FERM and PDZ domain-containing protein 4 (PDZ domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso) (Q14CM0)
Organism: Homo sapiens (Human)
Function: Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.
Subcellular location: Cell projection, dendritic spine {ECO:0000269|PubMed:19118189}.
Interaction partners:
- G-protein-signaling modulator 2
Sequence:
MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETGPENKGKHNLLGPDWNCIPQMTTFIGEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQLSQPGEAPCEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFALDDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV
Protein: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) (P30153)
Organism: Homo sapiens (Human)
Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q32PI5}. Nucleus {ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147}. Chromosome {ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147}. Chromosome, centromere {ECO:0000269|PubMed:16580887}. Lateral cell membrane {ECO:0000269|PubMed:15525651}. Cell projection, dendrite {ECO:0000269|PubMed:15525651}. Note=Centromeric localization requires the presence of BUB1 (PubMed:16580887). Recruited to chromatin and transcription pause-release checkpoint via its association with the Integrator complex (PubMed:34004147, PubMed:33243860). {ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147}.
Interaction partners:
- Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Striatin-interacting protein 1
- Striatin-3
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
- Integrator complex subunit 1
- Integrator complex subunit 5
- Striatin
Sequence:
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Protein: Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) (rNaPi IIb) (Q9JJ09)
Organism: Rattus norvegicus (Rat)
Function: Involved in actively transporting phosphate into cells via Na(+) cotransport.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:12893629}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of enterocytes. {ECO:0000250|UniProtKB:Q9DBP0}.
Interaction partners:
- Na
- Sodium-dependent phosphate transport protein 2A
- Sodium-dependent phosphate transport protein 2C
- Proto-oncogene tyrosine-protein kinase ROS
- Leucine-rich repeats and immunoglobulin-like domains 3
Sequence:
MAPWPELENAHPNPNKFIEGASGPQSSIPDKDKGTSKTNDSGTPVAKIELLPSYSALVLIEEPPEGNDPWDLPELQDNGIKWSERDSKGKILCIFQGIGKFILLLGFLYLFVCSLDVLSSAFQLVGGKMAGQFFSNNSIMSNPVAGLVIGVLVTVMVQSSSTSSSIIVSMVASSLLSVRAAIPIIMGANIGTSITNTIVALMQAGDRNEFRRAFAGATVHDFFNWLSVLVLLPLEAATHYLEKLTNLVLETFSFQNGEDAPDILKVITDPFTKLIIQLDKKVIQQIAMGDSEAQNKSLIKIWCKTISNVIEENVTVPSPDNCTSPSYCWTDGIQTWTIQNVTEKENIAKCQHIFVNFSLPDLAVGIILLTVSLLILCGCLIMIVKLLGSVLRGQVATVIKKTLNTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSAMTPLIGIGVISIERAYPLTLGSNIGTTTTAILAALASPGNTLRSSLQIALCHFFFNISGILLWYPIPFTRLPIRLAKGLGNISAKYRWFAVFYLIFFFLLTPLTVFGLSLAGWPVLVGVGVPIILLILLVLCLRMLQARCPRILPLKLRDWNFLPLWMHSLKPWDNIISLATSCFQRRCCCCCRVCCRVCCMVCGCKCCRCSKCCKNLEEEEKEQDVPVKASGGFDNTAMSKECQDEGKGQVEVLGMKALSNTTVF
Protein: Rhodopsin (Q9PTX9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}.
Interaction partners:
Sequence:
MNGTEGPNFYVPMSNRTGLVRSPFEEPQYYLAEPWQFSLLAAYMLFLILGSFPINALTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTVTLYTALHGYFLLGVTGCNIEGFFATLGGEIALWSLVVLAIERYIVVCKPMSTFRFGEKHAIIGVGFTWVMALTCAVPPLLGWSRYIPEGMQCSCGIDYYTPKPEVHNTSFVIYMFILHFSIPLLIIFFCYSRLLCTVRAAAAQQQESETTQRAEREVTRMVVVMVIAFLVCWVPYASVAWYIFANQGAEFGPVFMTVPAFFAKSAALYNPVIYIMLNRQFRNCMLSTVCCGKNPLAEDESSSAVSSKTQSSVVSSAQVSPA
Protein: CXXC-type zinc finger protein 1 (K7EQ21)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRERDGNERDSSEPRDEGGGRKRPVPDPDLQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKYFPSSLSPVTPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATPEPLSDEDLPLDPDLYQDFCAGAFDDHGLPWMSDTEESPFLDPALRKRAVKVKHVKRREKKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQPSSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFGSMYPTRIEGAKHTVSGSRCCAPSTHGTPKCQLTRYAGAPLYVMSLSSRVTSAACPSASAIAITAGRSCGVRKWTWSACVCGTSWTSCLSRSAMCAQP
Protein: Expressed protein (Transmembrane protein) (Q9SJ31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- NAD
- Alpha/beta-Hydrolases superfamily protein
- Small ribosomal subunit protein eS17w
- Polyprenal reductase 1
- Alpha/beta-Hydrolases superfamily protein
- At3g49420
- Small ribosomal subunit protein eS17z
- Ribosomal protein S24/S35
- Polyprenal reductase 2
- Sugar transporter ERD6-like 10
Sequence:
MAAKLCIPSSSFSHRTNDSITSSSSSYSSLLALPQFFCPPSPLGFPQFKLHAKLGGGDGEVKPKDKKKFITKDEEPEQYWQSVGEREGENPMKTPLPYIIIFGMSTPFVILAIAFANGWIKVPIR