wanglab/gogpt-training-data huggingface dataset:
Protein: Exocyst complex component 1 (Exocyst complex component Sec3) (Q8R3S6)
Organism: Mus musculus (Mouse)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular location: Midbody, Midbody ring {ECO:0000250|UniProtKB:Q9NV70}. Cytoplasm {ECO:0000250|UniProtKB:Q9NV70}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9NV70}. Cell membrane {ECO:0000250|UniProtKB:Q9NV70}. Note=Colocalizes with CNTRL/centriolin at the midbody ring. Localizes in cell membrane in the presence of SLC6A9. {ECO:0000250|UniProtKB:Q9NV70}.
Interaction partners:
- Exocyst complex component 7
- Exocyst complex component 3
- Exocyst complex component 5
- Exocyst complex component 4
- Exocyst complex component 2
- Exocyst complex component 6
- Exocyst complex component 8
- Exocyst complex component 6B
- Exocyst complex component 3-like protein
- Ras GTPase-activating-like protein IQGAP1
Sequence:
MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKVYKWVASSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEESVPSGENQSVAGGDEEAVDEYQELNAREEQDIEIMMEGCECAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNTLMQLLDEALTEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLVSSRGIEACTNAADALLQCMNVALRPGHDMLLAVKQQQQRFSDLREHFARRLASHLNNVFVQQGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYEREIKDFFEVAKMKMTGTSKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGSRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQNMSASMTEAEDLDGGSLLRQHSSGTLLPVSSEKDMIRQMMIKIFRCIEPELNNLIALGDKVDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEEVKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFINVEKVANESQKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH
Protein: Secoisolariciresinol dehydrogenase (EC 1.1.1.331) (Q94KL7)
Organism: Forsythia intermedia (Border forsythia) (Forsythia suspensa x Forsythia viridissima)
Function: Oxidoreductase involved in lignan biosynthesis. Catalyzes the stereospecific conversion of (-)-secoisolariciresinol to (-)-matairesinol via a lactol intermediate.
Interaction partners:
Sequence:
MAATSQVLTAIARRLEGKVALITGGASGIGETTAKLFSQHGAKVAIADVQDELGHSVVEAIGTSNSTYIHCDVTNEDGVKNAVDNTVSTYGKLDIMFSNAGISDPNRPRIIDNEKADFERVFSVNVTGVFLCMKHAARVMIPARSGNIISTASLSSTMGGGSSHAYCGSKHAVLGLTRNLAVELGQFGIRVNCLSPFGLPTALGKKFSGIKNEEEFENVINFAGNLKGPKFNVEDVANAALYLASDEAKYVSGHNLFIDGGFSVCNSVIKVFQYPDS
Protein: Glutathione peroxidase 2 (GPx-2) (GSHPx-2) (EC 1.11.1.9) (Glutathione peroxidase-gastrointestinal) (GPx-GI) (GSHPx-GI) (Phospholipid hydroperoxide glutathione peroxidase GPX2) (EC 1.11.1.12) (P83645)
Organism: Rattus norvegicus (Rat)
Function: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P18283}.
Interaction partners:
- Glutathione reductase
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Glutathione synthetase
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Polyunsaturated fatty acid 5-lipoxygenase
- Polyunsaturated fatty acid lipoxygenase ALOX15B
- Glutathione-specific gamma-glutamylcyclotransferase 1
- Putative glutathione-specific gamma-glutamylcyclotransferase 2
- Superoxide dismutase
- Heme oxygenase 1
Sequence:
MAYIAKSFYDLSAIGLDGEKIDFNTFRGRAVLIENVASLUGTTTRDYTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRHGGGFQPTFSLTQKCDVNGQNQHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRTFQTINIEPDIKRLLKVAI
Protein: Thiamine transporter (Q05998)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Responsible for intake of thiamine.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Thiamine thiazole synthase
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20
- Thiamine biosynthetic bifunctional enzyme
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI11
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5
- Thiamine biosynthesis regulatory protein
- Constitutive acid phosphatase
- Protein PDC2
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI12
Sequence:
MSFGSKVSRALRFLEIPVKDRASVSFLKNPDLQPIKSANQTWGFWSNFAYWGVMSFSVGTWMSASSALGVGLSYPETIGTFIVGDVLTIIFTLANSCPGYDWKVGFTLAQRFVFGIYGSAFGIIIRILMSIVNYGSNAWVGGLCINMILDSWSHHYLHLPNTLSSKVAMTTKELIGFIIFHVLTAFCYLMKPYHMNYILIWSCVATFFSMLGMVIYLAKQAHGVGELFTSTKSTATGSTKAWAWVYMISYWFGSVSPGSTNQSDYSRFGSSNWAIWAGTICALLIPTTLIPVFGVIGASTCDKLYGEQYWMPMDIFNHWLTTNYSAGARAGAFFCGLSFVLSQMSYTISNCGFASGMDLAGLLPKYVDIKRGALFAACVSWACLPWNFYNSSSTFLTVMSSFGVVMTPIISVMICDNFLIRKRQYSITNAFILKGEYYFTKGVNWRAIVAWVCGMTPGLPGIAWEVNNDYFHNTGIVNFFYGDSFFSFLISFFVYWGLCLLFPFKITVKHDDKDYYGAFTDEEARKKGMVPYSEISEEEIRAYTLGEGYTTGHEYRPEGSDDEIPELVKTSSENTNEFEIVHHKNNEKQSSTASEKAA
Protein: Cytochrome P450 1C1 (EC 1.14.14.1) (Cytochrome P450 CYP1C1) (A0PJ31)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MEAEFGLKSSSIMREWSGQVQPALIASFIILFFLEACLWVRNLTFKKRLPGPFAWPLVGNAMQLGQMPHITFSKLAKKYGNVYQIRLGCSDIVVLNGDAAIRKALVQHSTEFAGRPNFVSFQMISGGRSSTFTNYSKQWKTHRKVAQSTLRAFSMANSQTRKTFEQHVVGEAMDLVQKFLRLSADGRHFNPAHEATVAAANVVCALCFGKRYGHDDPEFRTLLGRVNKFGETVGAGSLVDVMPWLQSFPNPVRSVYQNFKTINKEFFNYVKDKVLQHRDTYDPDVTRDMSDAIIGVIEHGKESTLTKDFVESTVTDLIGAGQDTVSTAMQWMLLLLVKYPSIQSKLQEQIDKVVGRDRLPSIEDRCNLAYLDAFIYETMRFTSFVPVTIPHSTTSDVTIEGLHIPKDTVVFINQWSVNHDPQKWSDPHIFNPSRFLDENGALNKDLTNSVMIFSTGKRRCIGEQIAKVEVFLFSAILLHQCKFERDPSQDLSMDCSYGLALKPLHYTISAKLRGKLFGLVSPA
Protein: Reproductive homeobox 2A (Reproductive homeobox 2E) (Reproductive homeobox on X chromosome 2) (Q9D4Y3)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Reproductive homeobox 12
Sequence:
MERQSVNYKLDVGPEEDEENANGVKTLMVLLAGEGRNEGESGRGLPGSGASAAEGYRAGEISAGGPAAPVADLMDNSNQEDLGATGCDQEKEKQPEEPVPDSMGDLENVKRVSGPWSTVNPVRVLVPEFRHGWQQSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYRSYKRL
Protein: Homologous-pairing protein 2 homolog (A0A158RUX1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSKGRAEAAAGAAGILLRYLQEQNRPYSSQDVFGNLQREHGLGKAVVVKTLEQLAQQGKIKEKMYGKQKIYFADQDQFDMVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPDP
Protein: Orf490 protein (Q8HCR1)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
- Auxin response factor 11
- Transport inhibitor response 1-like protein Os05g0150500
- Orf181 protein
- Auxin response factor 16
- Auxin response factor 1
Sequence:
MDEEYGALMRNNTWHLVPATQGRNLIDCKWVYKIKRKADGTIDRYKARLVAKGFKQRYGIDYEETFSPVVKAATIRLILSLAVSNGWSLRQLDVQNAFLHGVLEEDVYMRQPPGYEDKSKLDYVCKLDKALYGLRHAPRAWFSRLSMKLQNLGFQPSKADASLFFYKKGTISIFVLIYVDDIIVASSCEKATSALLQDLKEEFALKDLGALHYFLGIEVNKVHDGIILTQEKYATDLLKRVGMHGCKEINTPLSTTDKLLAKEGEPLGAEDSTRYRSIVGALQYLTLTRPDIAFPVNKVCQYLHAPTSLHWTAVKRILRYLKGSLGLGLRICKSDSTLVSAFSDADWAGCPDDRKSTGGFAVFLGANLISWNAWKQATVSRSSTEAEYKALANATAEIISVQTLLKERGIAQPRAACLWCDNIGATSLSANPVFHARTKHIEVDYHFVRERVSQGLLDIRFVPSGDQVADGFTCNRPRRQYIQGGLHCGG
Protein: Peptidyl-prolyl cis-trans isomerase cyp8 (PPIase cyp8) (EC 2.3.2.27) (EC 5.2.1.8) (RING-type E3 ubiquitin transferase cyp8) (Rotamase cyp8) (Q09928)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
Subcellular location: Nucleus {ECO:0000269|PubMed:16134115}.
Interaction partners:
- Pre-mRNA-splicing factor cwf14
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-splicing factor spp42
- Pre-mRNA-splicing factor cwf15
- Pre-mRNA-processing protein 45
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-splicing factor prp5
- Peptidyl-prolyl cis-trans isomerase
Sequence:
MGKNTDKLYITQTEHSGVHGWHGGMSGIAQKNSTTSYKQLPFNYCSLSLQPFNHPCCLVDETKQAIIFDFRFIVPWLRKHGTNPINGQKASMSDLIKLKFAKNSAEEYCDPVTMKSFTRFSHIVAIRSTGNCFSWDTIERLNIKPKHWRDLVNEEQFTRDDIITIQDPHNVENRDFSAIQKQKETARDEKITKAKIALQASRAKSTESTSSPELSHSLDSSKSIASDMPIHRASHTTGYAAASLTSTSFTPVTKNERAIIAEEDYMLNHTRIKHKGYARIVTNHGEINIELHTDYAPHAVYNFVQLAKQGYYRNTIFHRNIARFMIQGGDPSGTGRGGQSIWGKPFKDEFCNPLKHDDRGIISMANRGKNTNGSQFFILYGPAKHLDNKHTIFGRVVGGLNVLDALEKVPTNSNDHPKLPIKLEDIIIFVDPFEEWKKDEREKEKRKRQEEEEENNLDRTSWTGRDLSASSTDHSLNASVGKYLKKEVSLEEKTFTSTVNPKKKKARTGFGNFDAW
Protein: Uncharacterized protein (Q386B4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLASWAVPHKPKTDQPGNGQVKETMIANRSLRKEGPAGAGNVKGAANSTHHLANAVGDADGGQGGAGSPKAAPSTATTESLRVPPTPTIRLSTIGGETFDKNDMGPRQEPSTTSSSSPKTRSARVAAHLVPAASMSGTLRREKEVMDPSLYHQLCYERLIRRQDPSKGVDKARQSYVYYNHRSKGCYIPHEKDPSELTLTYNHMYDFGDGSRFLAADGEPPRVNPNIGSVLDCNYNAASKSGASRDYARLRPSTTSERRAANEVCRIGLSTTNGKRTVAVDLARSLQLSDIRPQPFQIRKTVEDVISSDLRCVERAREGISSVVGKGKVLWAEVPEKLQATFSEVQGRFISPGAESRREDRNAAAGYRAGSTTLAQNANAVSYLPASSLPDRAEGATLPTHAPRSTNSKCGQSPMSKPVALTDLPDHVLLGFTANVCMPKINQRDGEATLPHTPLREESTESEDGNNLRGTYESTLQGTDPTGLRGTTNRGSNTVPEHARANGGEKLLPLVALAQLRDADYFLTTGPKPVSEIVKLLGPKWLPERPLPYETSRLSYCRKYDMGDANPPPNMIHWTLSKKLY
Protein: Interferon regulatory factor-7H (Q9HB64)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPVPERPAAGPDSPRPGTRRAAPRVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLSEADARIFKAWAVARGRWPPSSRGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSGDP
Protein: Cellulose synthase A catalytic subunit 3 [UDP-forming] (AtCesA3) (EC 2.4.1.12) (Constitutive expression of VSP1 protein 1) (Isoxaben-resistant protein 1) (Ath-B) (Protein ECTOPIC LIGNIN 1) (Protein RADIALLY SWOLLEN 5) (AtRSW5) (Q941L0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the primary cell wall formation, especially in roots.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:33729990}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cellulose synthase A catalytic subunit 1
- Cellulose synthase A catalytic subunit 6
- Endoglucanase 25
- Cellulose synthase A catalytic subunit 2
- Protein CELLULOSE SYNTHASE INTERACTIVE 1
- Cellulose synthase A catalytic subunit 5
- Chitinase-like protein 1
- Receptor-like protein kinase THESEUS 1
- Probable pectate lyase 13
- Vegetative storage protein 1
Sequence:
MESEGETAGKPMKNIVPQTCQICSDNVGKTVDGDRFVACDICSFPVCRPCYEYERKDGNQSCPQCKTRYKRLKGSPAIPGDKDEDGLADEGTVEFNYPQKEKISERMLGWHLTRGKGEEMGEPQYDKEVSHNHLPRLTSRQDTSGEFSAASPERLSVSSTIAGGKRLPYSSDVNQSPNRRIVDPVGLGNVAWKERVDGWKMKQEKNTGPVSTQAASERGGVDIDASTDILADEALLNDEARQPLSRKVSIPSSRINPYRMVIMLRLVILCLFLHYRITNPVPNAFALWLVSVICEIWFALSWILDQFPKWFPVNRETYLDRLALRYDREGEPSQLAAVDIFVSTVDPLKEPPLVTANTVLSILAVDYPVDKVSCYVSDDGAAMLSFESLAETSEFARKWVPFCKKYSIEPRAPEWYFAAKIDYLKDKVQTSFVKDRRAMKREYEEFKIRINALVSKALKCPEEGWVMQDGTPWPGNNTRDHPGMIQVFLGQNGGLDAEGNELPRLVYVSREKRPGFQHHKKAGAMNALVRVSAVLTNGPFILNLDCDHYINNSKALREAMCFLMDPNLGKQVCYVQFPQRFDGIDKNDRYANRNTVFFDINLRGLDGIQGPVYVGTGCVFNRTALYGYEPPIKVKHKKPSLLSKLCGGSRKKNSKAKKESDKKKSGRHTDSTVPVFNLDDIEEGVEGAGFDDEKALLMSQMSLEKRFGQSAVFVASTLMENGGVPPSATPENLLKEAIHVISCGYEDKSDWGMEIGWIYGSVTEDILTGFKMHARGWRSIYCMPKLPAFKGSAPINLSDRLNQVLRWALGSVEILFSRHCPIWYGYNGRLKFLERFAYVNTTIYPITSIPLLMYCTLPAVCLFTNQFIIPQISNIASIWFLSLFLSIFATGILEMRWSGVGIDEWWRNEQFWVIGGVSAHLFAVFQGILKVLAGIDTNFTVTSKASDEDGDFAELYLFKWTTLLIPPTTLLIVNLVGVVAGVSYAINSGYQSWGPLFGKLFFAFWVIVHLYPFLKGLMGRQNRTPTIVVVWSVLLASIFSLLWVRIDPFTSRVTGPDILECGINC
Protein: Serpin A3-1 (Endopin-1A) (Muscle endopin-1A) (mEndopin-1A) (Q9TTE1)
Organism: Bos taurus (Bovine)
Function: Potent inhibitor of the serine proteases elastase and trypsin. Moderately inhibits the serine proteases plasmin and chymotrypsin, and the thiol protease proenkephalin-processing enzyme. Does not inhibit the serine proteases cathepsin G, furin, kallikrein, thrombin, tissue plasminogen activator and urokinase, or the cysteine proteases cathepsin B, cathepsin L and papain.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000269|PubMed:10567388, ECO:0000269|PubMed:15647007}. Secreted {ECO:0000269|PubMed:10567388, ECO:0000269|PubMed:15647007}. Note=In longissimus muscle myocytes highest levels are found between the plasma membrane and the myofibrils and lower levels are found within the myofibrils. Localized to the chromaffin granules of the adrenal medulla and secreted in response to nicotine or KCL depolarization. {ECO:0000269|PubMed:10567388, ECO:0000269|PubMed:15647007}.
Interaction partners:
- Alpha-2-antiplasmin
- Alpha-2-HS-glycoprotein
- Plasminogen
- Fibrinogen beta chain
Sequence:
MRAERTSFLLALGLLVAGIRSVHCLPENVVVKDQHRRVDGHTLASSNTDFAFSLYKQLALKNPNKNVILSPLSVSIALAFLSLGARGSTLTEILEGLKFNLTEIQEKEIHHSFQHLLQALNQPSNQLQLSVGNAMFVQEELKLLDKFIEDAQVLYSSEAFPTNFRDSEAARSLINDYVKNKTQGKIEELFKYLSPRTELVLVNYIYFKAQWKTPFDPKHTEQAEFHVSDNKTVEVPMMTLDLETPYFRDEELGCTLVELTYTSNDSALFILPDEGKMRDLEAKLTPETLTRWRNSLQPRRIHELYLPKFSIKSNYELNDILSQLGIRKIFANADLSGITGTADLVVSQVVHGAALDVDEEGTEGAAATGISMERTILRIIVRVNRPFLIAIVLKDTQSIIFLGKVTNPSEA
Protein: SPC25 component of NDC80 kinetochore complex (C9JW94)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVEDELALFDKSINEFWNKFKSTDTSCQMAGLRDTYKDSIKAFAEKLSVKLKEEERMVEMFLEYQNQISRQNKLIQEKKDNLLKLIAEVKGKKQELEVLTANIQDLKEEYSRKKE
Protein: 3'3'-cGAMP-specific phosphodiesterase 1 (3'3'-cGAMP PDE 1) (V-cGAP1) (EC 3.1.4.-) (5'-pApG 5'-nucleotidase) (EC 3.1.3.-) (Q9KLR1)
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Function: Phosphodiesterase (PDE) that catalyzes the hydrolysis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP), leading to linear 5'-pApG. Also displays 5'-nucleotidase activity, further hydrolyzing 5'-pApG to 5'-ApG. Counteracts the function of the 3'3'-cGAMP synthase DncV, and is involved in the modulation of intracellular 3'3'-cGAMP levels. Enhances bacterial chemotaxis and inhibits intestinal colonization in vivo. Thus exerts a crucial role in regulating bacterial infectivity through catalyzing 3'3'-cGAMP degradation. Is specific for 3'3'-cGAMP since it cannot degrade other cGAMP linkage isomers (3'2'-, 2'3'-, and 2'2'-cGAMPs). Is also able to hydrolyze c-di-GMP but not c-di-AMP.
Interaction partners:
- diguanylate cyclase
- GGDEF family protein
- diguanylate cyclase
- diguanylate cyclase
- diguanylate cyclase
- GGDEF domain-containing protein
- Methionine synthase
- GGDEF family protein
- Sensory box/GGDEF family protein
- Flavodoxin
Sequence:
MRWSEIGCTMKSVNIEWNVNLRQAFFCIARALDSVGVDDINHGHRVGYMAYSCAQAMEWSEEECQLVFALGLIHDCGVAQKRDFYRLLENMQPDNTQQHCVRGNELLSNCPPLAPFADAILYHHTPWDELKNIAISDRNKRFAALIFLADRVDYLKELYPRDEYGNVTQEARNQVCLEIGRLSGSLFERDLVRTMQHLLSKEFIWFSMEHHHIEAMGHNLPSTPFFEQKLGVEEIMSIAMLMANVVDAKSQFTFQHSQKVAELCQHLAKELGLNVEMQKALYLTGLVHDIGKLHTPEEILHKPGKLNESEYLCIQRHSTDSRYTLQMVFGQSVVCEWAGNHHERLDGSGYPRGLQGAAIDLPSRIIAIADVFQALTQARPYRGSMSLNEVMNIMRHEVSCGRLDSQVFDVIVRNSQQYYQLSIAESPTEWA
Protein: MDM4 regulator of p53 (A0A087WZ58)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
Protein: RNA helicase (EC 3.6.4.13) (C7C1L7)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- non-specific serine/threonine protein kinase
- RNA helicase
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin
- RNA helicase
- RNA helicase
- Ubl carboxyl-terminal hydrolase 18-like isoform X1
- Ubl carboxyl-terminal hydrolase 18-like isoform X1
- Eukaryotic translation initiation factor 2-alpha kinase 3-like
- E3 ubiquitin-protein ligase FANCL
Sequence:
MYESEKRNLLRCSEYLVHILRPSYVKGFMTTYLQPEVAERILSEESKSVTSAAQVFLDQVCLLDELGWYQALLDALDAEDYKGLCEALKKWDFQILESTKIHRVLLERIEPSFTKMIKPRDLLLHLGDCLRKREYEEIQAIENQKGPIAAAERLTDCLKRSDKQNWFKLLKSALLSCDLTDALQLLEPDTESSVSEMETGDEEEGETMTTISFQYTEQFDDDDGMLMSGNHLTPSETPPTSATGANSGVGEVQKGGGGEKSRGGEKKMREYQRELAEPVFQGKNTVICAPTGCGKTVVALAICEHHLKVKGKGAKVVFMATKVDVFNQQYKLFQDHFQEKDPDIRINGLCGNQGDQLSMKVVMENNDIIVLTPQILVNAVAGGEITSLSCFSLLILDECHNTTGKHPYNIIMTSYLDAKLSKEQSGQHLPQIVGLTASVGIGSFKNQSEAENNICQLCASLDSRIISTIHTNTDELQSYVHTPEKEFFLVEKRHTDPFIRIIRDIMAKIEGLAKTVYNIESLSAIENRDYGSQKYEQWIVDVQKKCRVLQLKDQEEESRVCRALYNYTEHLRKYNDALIINEDARTKDALDYLSVFIQQVKNAGHDETEQRLTAYFDGQQGVLRGLSSGGQKENPKLDMLQYILEEQYRQNDETKSVLFVRTRALADALKSWIEESDSLKFLKPGVLIGRGHKSSQLTGTRMTLNSKKGVLDSFKSFDNQSKILIATSVADEGIDIPQCNLVLMYEYVGNVVKMVQVRGRGRAQGSKCILVSDKKDRIDKEKHNMEKEKIVEKAIRKLQDTPTEMLRKMEVFQRGDKVCRDMVKMVPERRLTEGSYQLLCSKCKKHSCYTDDIRVLQDSHHIVLDPTLFSRARTEPHPKPKGFMGLVKTKKLFCHCGLDWGIVASYLSIQNLPVLKIESFVVKNCVTEQQRYYRKWRDVTFSMKTFELTDIADSWNPLLEDQ
Protein: Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (Ribonucleotide reductase M2 b) (Q7ZYW0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Ribonucleoside-diphosphate reductase large subunit
- Adenylate kinase 9
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase 6
- Nucleoside diphosphate kinase
- Nucleoside diphosphate kinase 3
- Nucleoside diphosphate kinase 7
- Nucleoside diphosphate kinase.
- UMP-CMP kinase
- Guanylate kinase
Sequence:
MNSCTSNTPTVITGYQNGHKDVDPNSVEDEPLLRENPKRFVIFPIQYPDIWKMYKQAQASFWTVEEVDLSKDLTHWDGLKSEEKHFISHVLAFFAASDGIVNENLVQRFSQEVQLPEARSFYGFQILIENVHSEMYSMLINTYIRDLKERDYLFNAVQTMPCVRRKADWALQWISDTNSTFGERLVAFAAVEGIFFSGSFAAIYWLKKRGLMPGLTYSNELISRDEGLHCNFACLIYSYLVKKPSVDRVNDIIAKAVSIEQEFLTEALPVNLIGMNCSLMKQYIEFVADRLLTDLGLPKAYCSENPFDFMESISLEGKTNFFEKRVAEYQRLGVMSNVKDCEFTLDADF
Protein: Acetyltransferase SACOL1063 (EC 2.3.1.-) (GCN5-related N-acetyltransferase) (GNAT) (Q5HH30)
Organism: Staphylococcus aureus (strain COL)
Function: Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It displays the highest activity for L-threonine. It can also use L-tryptophan, and to a much lesser extent L-tyrosine.
Interaction partners:
Sequence:
MFSKVNNQKMLEDCFYIRKKVFVEEQGVPEESEIDEYESESIHLIGYDNGQPVATARIRPINETTVKIERVAVMKSHRGQGMGRMLMQAVESLAKDEGFYVATMNAQCHAIPFYESLNFKMRGNIFLEEGIEHIEMTKKLTSLN
Protein: A-kinase anchor protein SPHKAP (SPHK1-interactor and AKAP domain-containing protein) (Q6NSW3)
Organism: Mus musculus (Mouse)
Function: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Note=Colocalizes with SPHK1 in the cytoplasm. {ECO:0000250}.
Interaction partners:
Sequence:
MDVNSRLSVQSNVESPLMHEGPEPQQITSSAAGNLAGSITACKKVLRSNSLLESTDYWLQNQRTPCQIGFVEDESENCASVCFVNLDVNKDACITENLQQKLVNVSPDLPNLISSMNVQQPKENEIVLLSGLASGNPQADFDVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLIGLEVVQERQLHLETNVLKLEDDTNCSLSSIEEDFLTASEHLEEEIEVDDCRSGLENTNVSANVLESKKPKETTQEGWDYHKEKLHCALGEKHIRKHRTPSTKTEGSKENTEENTSLKSLNRLVRPSHLKSEVAGNKQLATNYSYPENIKGELETSQMLFIPRDAYLSMVKKDVLSPCSVLSEQGGSHRDHDVTPNPLPPVQNGEASTGEYATNLAESVMQDAFIRLSQSQPTLPQESAVSFSMRSALLPSGCCTKDMVVPRSWNELPKIVIVQSPDGSDTVPEPNVSSWPDMEFVETSGIFSADSSSRPTQSALEVALACAATVIGTISSPQATERFAMEQESLVSTYAQRGTGVQQTQVPQAFMAPSTTEYSFPSALCGMTQVASAVAVCGLCEKEEATCPVAPTDLLPTSGASEEISSIGSLVMERSTELGKEAIAEALLREATLILARPDAYSSLGELLESVNQRIIETTSKTQTLCTESVQRNELAHTLSNVILKHSVDELHQKTTMAHPTDERHPCGTLDTLMESVNQLLHNVICFTFKKMNHIVTLSEHPSFDQAAGQAWVKAFACPSSQPLSNAHGTGLVIRNLVEDASPKSNKGGARPELVNNPRLQSEFSCSHRMFDSTAKSFPKEIYLKGIMGEDTRNPHHTLNYDSNERRASTDLGKLTTASEGCSGFQETEDSIVPNTQEKYICATPLNNEAQVNLSLLGDDLSVPAQSTLEAKQSEVYGITDFAEELAETVVSMATEIAAICLDNSNGKQPWFCAWKRGNEFLTAPNGSCRSLKRKKENSSAGSTVRKHKPPRLSEIKRKADEHPELKEKLMNRVMDESMNLEDIPDSVSTFANEVAAKIMNLTEFSMVDGVWQGQSCSRTRLLGGDRWNRLKASSCESIPEEDSEARVFVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVKQMENEGRGFELLLDYYAGKNASSIMSSAMQQACQKNDHLNVRPSCPSKQSSTESITEEFYRYMLRDIAKESKDGASSRRSSHDWTTGLLSPSTRSPLCYRQSSMPDSRSPCSRLTVNAPVKANSLDGFAQNCPQDSVNVQPVSRASSSGLCKSDSCLYRRSGTDQITNMLIHETWASSIEALMRKNKIIADDSEAANASPGPVSSGSPLQVEKNANRLATSKGHRGPTLLVQESVDYQRKDAVTEGNHSPVSSPGKTAPVKKPSDFDPRRETSACHNAAGLNSPRRSLCSRDVPLIQIETDQKEECIGEPGPFLSQSGSLEETEGHQPEETIPDVARNEDTAPSTCQSSRDSLETSGEVEVEVLKEDIPRDESRNPPSSSEESTGSWSQLANEEDIPDDTSSFLQLSERSMSNGNSSGTSSLGIMDLDIYQESIPSSPMINELVEEKEILKEQSESIKEHASGLPGRAASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQESRIEKFLDVVKLVQQKSWKVGDIFHAVVQYCKLHAEQKERTPSLFDWLLELG
Protein: Cilia- and flagella-associated protein 298 (Protein kurly homolog) (P57076)
Organism: Homo sapiens (Human)
Function: Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29601588}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A0A1L8HCK2}. Note=Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization. {ECO:0000250|UniProtKB:Q5U3Z0}.
Interaction partners:
- Dynein axonemal assembly factor 1
- Dynein axonemal assembly factor 5
- Dynein axonemal assembly factor 3
- Dynein axonemal assembly factor 4
- Dynein axonemal assembly factor 11
- Zinc finger MYND domain-containing protein 10
- Sperm-associated antigen 1
- Dynein regulatory complex subunit 2
- Cilia- and flagella-associated protein 300
- Dynein axonemal assembly factor 19
Sequence:
MVLLHVKRGDESQFLLQAPGSTELEELTVQVARVYNGRLKVQRLCSEMEELAEHGIFLPPNMQGLTDDQIEELKLKDEWGEKCVPSGGAVFKKDDIGRRNGQAPNEKMKQVLKKTIEEAKAIISKKQVEAGVCVTMEMVKDALDQLRGAVMIVYPMGLPPYDPIRMEFENKEDLSGTQAGLNVIKEAEAQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQRGQGAPAREPIISSEEQKQLMLYYHRRQEELKRLEENDDDAYLNSPWADNTALKRHFHGVKDIKWRPR