wanglab/gogpt-training-data huggingface dataset:
Protein: Tubulin alpha-1 chain (EC 3.6.5.-) (P09733)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11739794}.
Interaction partners:
- Tubulin beta chain
- Dynein heavy chain, cytoplasmic
- Protein BIM1
- Protein STU2
- WD repeat-containing protein PAC11
- Tubulin alpha-3 chain
- Transgelin
- Kinesin-related protein SMY1
- Actin
- Ypt/Rab-type GTPase YPT7
Sequence:
MREVISINVGQAGCQIGNACWELYSLEHGIKPDGHLEDGLSKPKGGEEGFSTFFHETGYGKFVPRAIYVDLEPNVIDEVRNGPYKDLFHPEQLISGKEDAANNYARGHYTVGREILGDVLDRIRKLADQCDGLQGFLFTHSLGGGTGSGLGSLLLEELSAEYGKKSKLEFAVYPAPQVSTSVVEPYNTVLTTHTTLEHADCTFMVDNEAIYDMCKRNLDIPRPSFANLNNLIAQVVSSVTASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVSYSPVLSKSKAFHESNSVSEITNACFEPGNQMVKCDPRDGKYMATCLLYRGDVVTRDVQRAVEQVKNKKTVQLVDWCPTGFKIGICYEPPTATPNSQLATVDRAVCMLSNTTSIAEAWKRIDRKFDLMYAKRAFVHWYVGEGMEEGEFTEAREDLAALERDYIEVGADSYAEEEEF
Protein: DNA mismatch repair protein S5 domain-containing protein (Q8BZC3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MIRCLSDDVKTKLRSGLAISSLGQCVEELTLNSIDAEATCVAIRVNMETFQVQVIDNGLGMAGDDVEKVGNRYFTSKCHSVRDLENPAFYGFRGEALASIADMAGAVEISSKKNTTLKTFVKMFQNGKALATHEADLTRPSVGTTVTVYNLFYQFPVRRKSMDPRLEFEKVRQRVEALSLMHPSISFSLRNDVSGSMVLQLPKTKDICSRFCQIYGLGKSQKLREIRFKYKEFEFSGYISSEAHYNKNMQFLFVNRRLVLRTKLHKLIDFLLRKESIICRPKNGSASRQMNSSPRHRSASELHGIYVINVQCPFCEYDVCIEPAKTLIEFQSWDTVLICIQEGVKRFLKQEKLFVELSGEDIKEFNEDNGFSLFGTTLQTHVSTHEKCDQSSFREACNKILDSYEMFNLQSKAVKRIATLENKTRQNPGDSETI
Protein: Sema domain-containing protein (Q9TYS4)
Organism: Caenorhabditis elegans
Interaction partners:
- Plexin-2
- Sema domain-containing protein
Sequence:
MVHLRIFIFLLAPLGSASFFNPDTNVSRVDVSHLSRALSYGANEKLVILHKLPGEYVLLGGRNHVYNISISSMLEIARYEWTSSDEARTNCAAISQTPASCENFIRTYFELTNDTLILCGTHALQPTCAEFRKGNAKPQRLISAVGMSPIDADSTAPFIRSNENIITVNVAELSSSEPLLVRRNVIKMWKGIENDVILRTPRGLSSFEQANFLSMHKVKKEVLFFFSESPMETEGCGLHKVARVGRVCEDDPGGRLSYNKEWSSYEKARIECSIEETDTDTFYFNQFAGVAESPTSFYGAFRSQLAGIGASAICKYSKKVISGSFASGYKESTPDTCSRANDIEELSRIRLKPLIKQKISANPIYIFHGKDRFVHVLAQEDTRDLSNRAYDILYVATNLGNILKIVVPSTDKTGRHAVTLKVLPTNSKIVDMSLYSKNNLEELIVITEQSVLKVPTATCHLASNCAECLAHGDPHCAWADGVDCIDIRTDQRKSASQDSGTCDVVSFENHKPVMIAPLKNKESAKIPVCLCETEKQKKPCATEVIQKEIVLTGGSEFWKYILVFAVGVLTGSIFHYCYFYFSRHIGDKASSSSRSSSSMTRPITTSSSARLPIDAFTTSSIADEMFSSTLSSANRFNSVSMHSSIRTYC
Protein: Plexin-D1 (Q3UH93)
Organism: Mus musculus (Mouse)
Function: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Mediates anti-angiogenic signaling in response to SEMA3E. Required for normal development of the heart and vasculature.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17318185, ECO:0000269|PubMed:19027330}; Single-pass membrane protein {ECO:0000269|PubMed:17318185, ECO:0000269|PubMed:19027330}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q9Y4D7}.
Interaction partners:
- Semaphorin-3E
- Semaphorin-4A
- Neuropilin-1
- Semaphorin-3C
- Vascular endothelial growth factor receptor 2
- PDZ domain-containing protein GIPC1
- Semaphorin-3A
- Semaphorin-3D
- Semaphorin-4D
- Semaphorin-4C
Sequence:
MARRAAGGAPPSARAAAAVPLRPRPHSRGPGLLPLPLLLLLGAARAGALEIQRRFPSPTPTNNFALDGTAGTVYLAAVNRLYQLSSANLSLEAEATVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVVACGSIYQGLCQLRRRGNISALAVSFPPAAPTAEPVTVFPSMLNVAANHPNASTVGLVLPPTSGTGGSRLLVGATYTGFGSAFFPRNRSLEDHRFENTPEIAIRSLDARGDLAKLFTFDLNPSDDNILKIKQGAKEQHKLGFVRAFLHPAVPPHSAQPYAYLALNSEARAGDKDSQARSLLARICLPRGAGGDAKKLTESYIQLGLQCAGGAGRGDLYSRLVSVFPAREQFFAVFERPQGAPGARNAPAALCAFRFDDVQAAIRAARTACFVEPAPDVVAVLDSVVQGTGPACESKRNIQLQPEQLDCGAAHLQHPLTILQPLRASPVFRAPGLTAVAVASANNYTAVFLGTATGRLLKISLNESMQVVSRRVLTVAYGEPVHHVMQFDPMDPGYLYLMTSHQMARVKVAACEVHSTCGDCVGAADAYCGWCTLETRCTLQQDCTNSSQPHFWTSASEGPSRCPAMTVLPSEIDVHRDYTGMILQISGSLPSLSGMEMACDYGNGVRTVARVPGPAYDHQIAYCNLLPRAQFPSFPAGQDHVTVEMSVRVKGHNIVSANFTIYDCSRIGQVYPHTACTSCLSTQWPCSWCIQLHSCVSNQSQCQDSPNPTSPQDCPQILPSPLAPVPTGGSQDILVPLTKATFFHGSSLECSFGLEESFEAVWANNSLVRCNQVVLHTTQKSQVFPLSLKLKGPPDRFLDSPNPMTVVVYNCAMGSPDCSQCLGREDLGHLCVWNDGCRLRGPLQPLPGTCPAPEIRAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGSVACEPLADRYTVSEEIVCATGPAAGAFSDVVTVNVSKEGRSREQFSYVLPTVHSLEPSMGPKAGGTRITIHGSDLNVGSMLQVLVNDTDPCTDLTRTATSITCTVPGGTLPSPVPVCVRFESRGCVHGNLTFWYMQNPVITAISPGRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTFCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEAAEELLDPAEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLESHEYHIKIGQVSCDIQIISDRVIHCSVNESLGTAEGQLPITIQVGNFNQTIATLQLGGSETAIVVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSKTLNSQGGSPPQETHPLLGEWNIPEHCRPSMEEGISLFSSLLNNKHFLIVFVHALEQQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSICMYGCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWFASSTQSYVLRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLTDKKDSTLGRVKDLDTEKYFHLVLPTDELVEPKKSHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIEKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKTVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARRTQLQHKFEQVVALMENNIYECYSEA
Protein: Conserved protein (O86315)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable membrane protein
- Conserved hypothetical membrane protein
- Possible membrane protein
Sequence:
MGSVNRVYLARLSRMSVLGPLGESFGRVRDVVISISIVRQQPRVLGLVVDLATRRKIFIPILRVAAIEPHAVTLSTGNVSLHRFEQRPGEALALGQVLDTLVKVNDPALPELAGVDVVVTDLGVEQTRSRDWMVTRVAVRTQRRLRRRCPVHVVDWHNVAGLTPSALAMPGQDVAQLLDQFEGWKAVDVADAIRGLPPKRRHEVFKALHDKRLADVLQELPELDQAEVLSQLGTERAADVLEEMDPDDAADLLAVLNPTEAELLLTRMDPGDSGQVRRLLTHSPDTAGGLMTSDPVVLTPDTSIAEALARVRDPDLTPALASMVFVARPPTATPTGHYLGCVHLQRLLRDPPAELVGGVVDTDLLTLTPETPLAAVTRYFAAYNLVCGPVVDDENHLLGAVTVDDLLDHLLPHDWRVDMPELDPSGAPDRPGGPR
Protein: Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) (Q9BX40)
Organism: Homo sapiens (Human)
Function: Required for oocyte meiotic maturation. May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (By similarity).
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q8CGC4}. Note=Localizes to MARDO (mitochondria-associated ribonucleoprotein domain), a mitochondria-associated membraneless compartment that stores mRNAs in oocytes. {ECO:0000250|UniProtKB:Q8CGC4}.
Interaction partners:
- Probable ATP-dependent RNA helicase DDX6
- Eukaryotic translation initiation factor 4E transporter
- m7GpppN-mRNA hydrolase
- Enhancer of mRNA-decapping protein 3
- mRNA-decapping enzyme 1A
- Protein PAT1 homolog 2
- Eukaryotic translation initiation factor 4E type 1B
- mRNA-decapping enzyme 1B
- Polyadenylate-binding protein 1-like
Sequence:
MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAASSLLSQQYAASLGLGAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRRPQRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSAEAPAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV
Protein: Transcriptional regulator GadE (P63204)
Organism: Escherichia coli (strain K12)
Function: Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci.
Interaction partners:
- Acid stress chaperone HdeA
- Glutamate decarboxylase alpha
- Glutamate decarboxylase beta
- Protein HdeD
- Glutamate/gamma-aminobutyrate antiporter
- HTH-type transcriptional regulator GadX
- Outer membrane protein Slp
- Acid stress chaperone HdeB
- Putative magnesium transporter YhiD
- HTH-type transcriptional regulator GadW
Sequence:
MIFLMTKDSFLLQGFWQLKDNHEMIKINSLSEIKKVGNKPFKVIIDTYHNHILDEEAIKFLEKLDAERIIVLAPYHISKLKAKAPIYFVSRKESIKNLLEITYGKHLPHKNSQLCFSHNQFKIMQLILKNKNESNITSTLNISQQTLKIQKFNIMYKLKLRRMSDIVTLGITSYF
Protein: BZIP domain-containing protein (A7SDT1)
Organism: Nematostella vectensis (Starlet sea anemone)
Interaction partners:
- BZIP domain-containing protein
- BZIP domain-containing protein
- BZIP domain-containing protein
Sequence:
MGSQVERPESVATKYFVCIFVVTTCVEWPHNCLDEEHITRESFYIRHLSNKNKILLLQSLRNSTTMSDANQNGVVENGEEGVARDKTTHDFVTGLKEREELKQQLHTKDREVNTLKGQNYDLMKKIDNLEKQIAELNKDGSKKRKQSHFSKPKRPARRKKPEEKVSEPGKSTHDGYKEGSDPFEDPEKLYAEIAAKYPDMPLSQVLTAEKRFVEADINRDGTIDPEELEKLLDSSSAAGGTALFTQQQIKEIMKQVDLDNTNSIDFMECLGLLDLLRQNRKTGLPPTMQQNSLSSARGSYTDQLCITVKRYNLLCIFIESNVTLAMIPAPKQIAKTTWFKIVILFLNLPCILHGIFRDHVKHKISTCLLGLEIDTQISTLWSYDKLHACATSTITSSSAEHVRAASITMATNTTYAPSGSSHGAVSAPVKEELKHVIQSRRACQGLGRLSLPIVTEKKPPPKNSAIISVFLCKERGRGTLVSPLGSDLSVFYFGFVCYKNKALSVFFCQLTPAEELKIIRRRQRNKQAASRCREKRRQRLEELQREATELEEQNAEVERDIATLRVEYNELEALLTEHACVLPYGAGDHVGRQLGPPL
Protein: Zinc finger E-box-binding homeobox protein zag-1 (Zinc finger involved in axon guidance 1) (ZAG-1) (G5EBU4)
Organism: Caenorhabditis elegans
Function: Transcription factor. Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA. Acts as a transcriptional repressor to regulate multiple, discrete, neuron-specific aspects of terminal differentiation, including cell migration, axonal development and gene expression. Promotes touch receptor neuron differentiation by repressing the expression of egl-44 and egl-46. As egl-44 and egl-46, probably acting as a heterodimer, repress expression of zag-1 in FLP neurons, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates. Required for axon guidance. Involved in the proper development of the pharynx. Required for pharynx isthmus peristalsis, probably via a role in the differentiation of the M4 cholinergic motor neuron. Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter. May also act as a transcriptional activator of the homeodomain ceh-28.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12835394}.
Interaction partners:
- C-terminal-binding protein 1
- Aryl hydrocarbon receptor protein 1
- Transcription enhancer factor-like protein egl-44
- Homeobox protein ceh-28
Sequence:
MVDIAEAMPTTASSLPSDEALRKFKCPECTKAFKFKHHLKEHIRIHSGEKPFECQQCHKRFSHSGSYSSHMSSKKCVQQASPSMVTPFNPYQLMMYRNIMLQLQTPQVSFLPSTAANNMDYMSLLQANLFQSLENGTSPTPTQEPSAPASPEPKIEVVDEPEVSSEVKTEVKTEVKTEDSVPEESITPAVSMSLSPAPEQNGNESMNNGGSGSDGKSSPDWRPLRSRSFLNDSQVAVLQNHFKRNPFPSKYELSAVAEQIGVNKRVVQVWFQNTRAKERRSNRLPSMPRGSVASAAAAAATSPTVWQTPVQLMAAWASQFSNGNNSLTASQDERNNENTDEVMDHDGLKDGKETPLDLTLSTDDTEPEWSPEKLIGFLDQTGGVIQELLRQAGNGFVTNQEDEEEKPIKAEESPVSSGSSSIWPSFIGQYPSILDSASLSVLEKALDQQKSSEDDASSLCSNESKLLKFPTTPLKEEEGLFSCDQCDKVFGKQSSLARHKYEHSGQRPYKCDICEKAFKHKHHLTEHKRLHSGEKPFQCDKCLKRFSHSGSYSQHMNHRYSYCKPYREQPASPSDVLNGGSVTVSPSSSNTPPPST
Protein: Rho family-interacting cell polarization regulator 2 (Myogenesis-related and NCAM-associated protein) (A9ZLX4)
Organism: Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Function: Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17825087}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Y4F9}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9Y4F9}. Apical cell membrane {ECO:0000250|UniProtKB:Q7TP54}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q80U16}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q7TP54}.
Interaction partners:
Sequence:
MSIGSHSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENTSALKKPQAKVKKMHNLGHKNSTTPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKLTAQLKDMRRNSRLGVLYDLDKQIKAVERYMRRLEFHISKVDELYEAYCIQRRLCDGASKMKQAFAMSPTSKAARESLTEINRSYKEYTENMCTIEAELENLLGEFCIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGKIEVNGKQSWDGEEMVFLPLIVGLISIKVTEVKGLATHILVGSVTCETKDLFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDLTPSTGNVSKASALQRRMSMYSQGTPETPTFKDHSFFRWLHPLQDRPRLAILDALQDTFFDKLRRSRSFSDLPSLRLSPKAGLELYSNLPDDVFENGTATTEKRPLSFTFGDLPYEDRVPPANSAEPSSAHVTSSPDIATTATQHRARAQTAAAVTPAEGKACPGVRCEPRGHGDSCQEYPPGFQKPSDTGSDRVFIEANVPVSLLQDTDEGSELKPVELDTYEGNITKQLVKRLTSAEVPGTPERLPCEGSISGESEGYKSYLDGSIEEALQGLLLALEPHKEQYKEFQDLDQEVMHLDDILKCKPAVSRSRSSSLSLTVESALESFDFLNTSDFDDEDGGGEEVCNGGGGADSVFSDTEVEKNSYRTEHPEARGHLQRSLTEDTGVGTSVAGSPLPLTTGSDSLDITIVKHLQYCTQLIQQIVFSRKTPFVTRDLLDKLSRQTLVMENIAEISTENLGSITSLTDAIPEFHKKLSLLAFWMKCTGPSGVYHTSADKMMKQLDINFAATVNEECPGLAETVFRILVSQILDRTEPVLYSTMSSEIITVFQYYNYFASHSVNDLGSYLLQLAKEASVVQMLQSVKDGKLQQNVSKINSNNLPPQQEVLRALALLLNENKNEVSETVASLLTATAENKHFREKALIYYCEALTQPNLQLQKAACLALRYLKATESIKMLVMLCQSDNEEIRKVASETLLSLGEDGRLAYEQLDNSPGNLSELEVAGELNLPQLSRRTCLSVTATEEGWSCH
Protein: PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM (EC 2.7.1.121) (Dihydroxyacetone kinase subunit M) (P37349)
Organism: Escherichia coli (strain K12)
Function: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.
Interaction partners:
- PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL
- PEP-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK
- Glycerol dehydrogenase
- PTS system glucose-specific EIIA component
- Multiphosphoryl transfer protein 2
- Multiphosphoryl transfer protein 1
- PTS-dependent dihydroxyacetone kinase operon regulatory protein
- Aerobic glycerol-3-phosphate dehydrogenase
- Anaerobic glycerol-3-phosphate dehydrogenase subunit A
- Phosphocarrier protein HPr
Sequence:
MVNLVIVSHSSRLGEGVGELARQMLMSDSCKIAIAAGIDDPQNPIGTDAVKVMEAIESVADADHVLVMMDMGSALLSAETALELLAPEIAAKVRLCAAPLVEGTLAATVSAASGADIDKVIFDAMHALEAKREQLGLPSSDTEISDTCPAYDEEARSLAVVIKNRNGLHVRPASRLVYTLSTFNADMLLEKNGKCVTPESINQIALLQVRYNDTLRLIAKGPEAEEALIAFRQLAEDNFGETEEVAPPTLRPVPPVSGKAFYYQPVLCTVQAKSTLTVEEEQDRLRQAIDFTLLDLMTLTAKAEASGLDDIAAIFSGHHTLLDDPELLAAASELLQHEHCTAEYAWQQVLKELSQQYQQLDDEYLQARYIDVDDLLHRTLVHLTQTKEELPQFNSPTILLAENIYPSTVLQLDPAVVKGICLSAGSPVSHSALIARELGIGWICQQGEKLYAIQPEETLTLDVKTQRFNRQG
Protein: Small ribosomal subunit protein eS21 (40S ribosomal protein S21) (P63220)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:P63221}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P63221, ECO:0000269|PubMed:25957688}.
Interaction partners:
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein P2
- Large ribosomal subunit protein uL11
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS12
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein eL29
Sequence:
MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTGRFNGQFKTYAICGAIRRMGESDDSILRLAKADGIVSKNF
Protein: P2Y purinoceptor 14 (P2Y14) (G-protein coupled receptor 105) (UDP-glucose receptor) (VTR 15-20) (O35881)
Organism: Rattus norvegicus (Rat)
Function: Receptor for UDP-glucose coupled to G-proteins.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- P2X purinoceptor 1
- P2X purinoceptor 6
- P2X purinoceptor 2
- P2X purinoceptor 3
Sequence:
MDNTTTTEPPKQPCTRNTLITQQIIPMLYCVVFITGVLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLSDSGLGPWQLNVFVFRVSAVIFYVNMYVSIAFFGLISFDRYYKIVKPLLVSIVQSVNYSKVLSVLVWVLMLLLAVPNIILTNQSVKDVTNIQCMELKNELGRKWHKASNYVFVSIFWIVFLLLTVFYMAITRKIFKSHLKSRKNSISVKRKSSRNIFSIVLAFVACFAPYHVARIPYTKSQTEGHYSCQAKETLLYTKEFTLLLSAANVCLDPISISSYASRLEKS
Protein: Transcriptional repressor PhlF (Q4K422)
Organism: Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Interaction partners:
Sequence:
MARTPSRSSIGSLRSPHTHKAILTSTIEILKECGYSGLSIESVARRAGASKPTIYRWWTNKAALIAEVYENESEQVRKFPDLGSFKADLDFLLRNLWKVWRETICGEAFRCVIAEAQLDPATLTQLKDQFMERRREMPKKLVENAISNGELPKDTNRELLLDMIFGFCWYRLLTEQLTVEQDIEEFTSLLINGVCPGTQR
Protein: Tryptophan RNA-binding attenuator protein-like protein (Q8RXM5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Altered inheritance of mitochondria protein
- Calcium-dependent lipid-binding
- Derlin-2.1
- Derlin-2.2
- Jacalin-related lectin 34
- ERAD-associated E3 ubiquitin-protein ligase HRD1B
- Protein OS-9 homolog
- Eukaryotic initiation factor 4A-2
- ERAD-associated E3 ubiquitin-protein ligase component HRD3A
- ERAD-associated E3 ubiquitin-protein ligase HRD1A
Sequence:
MAAPFFSTPFQPYVYQSQQDTITPFQILGGESQVVQIMLKSEEKVIAKPASMCYMSGSIEMENTYTPEQEVGVLQWILGKSVSSVVLRNTGQNDGFVGIAAPYLARILPIDLAMFGGEILCQPDAFLCSVHDVKVVNSVDQRARNIVAAGAEGFLRQRLSGQGLAFILAGGSVVQKVLEVGEVFSIDVSCIAALTPSIDVRIKNNAPFRRALFGGDNVVMATLTGPGIVFIQSLPFHRLSQRIARSVTSPNMRENPKLLIQIAIFAFLAYAVILSSLILTEV
Protein: Cytochrome b561 homolog 1 (P76345)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Metal-binding protein ZinT
- Zinc import ATP-binding protein ZnuC
Sequence:
MNRFSKTQIYLHWITLLFVAITYAAMELRGWFPKGSSTYLLMRETHYNAGIFVWVLMFSRLIIKHRYSDPSIVPPPPAWQMKAASLMHIMLYITFLALPLLGIALMAYSGKSWSFLGFNVSPFVTPNSEIKALIKNIHETWANIGYFLIAAHAGAALFHHYIQKDNTLLRMMPRRK
Protein: Nuclear protein localization protein 4 homolog (Protein NPL4) (Q9ES54)
Organism: Rattus norvegicus (Rat)
Function: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10811609}. Endoplasmic reticulum {ECO:0000269|PubMed:10811609}. Nucleus {ECO:0000269|PubMed:10811609}. Note=Associated with the endoplasmic reticulum and nuclear.
Interaction partners:
- Ubiquitin recognition factor in ER-associated degradation protein 1
- Transitional endoplasmic reticulum ATPase
- FAS-associated factor 2
- FAS-associated factor 1
- UBX domain-containing protein 7
- NSFL1 cofactor p47
- UBX domain-containing protein 7
- Deubiquitinating protein VCPIP1
- ASPSCR1 tether for SLC2A4, UBX domain containing
- Ubiquitin-associated domain-containing protein 2
Sequence:
MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSSKSLHLLKIKHGDLLFLFPSSLAGPSSEMETSTSVGLKAFGAPHVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIASKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLHEFGAVGGSARAATSAMWACQHCTFMNQPGTGHCEMCSLPRT
Protein: Metalloendopeptidase (EC 3.4.24.-) (Q49II8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
EHEAKLQRLREELSRPVIEGHHRQSHHQKQAQHRQHHQSHHRKKQHRQQQHHRRRGQSTTQYVNHSPPGFNQSQQAQQQSVPEMDLLKAETSKDEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCGCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFD
Protein: Small EDRK-rich factor 1 (Protein 4F5) (h4F5) (SMA modifier 1) (O75920)
Organism: Homo sapiens (Human)
Function: Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:31034892}. Nucleus {ECO:0000269|PubMed:31034892}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex assembly factor 3
- Survival motor neuron protein
- Baculoviral IAP repeat-containing protein 1
- G-patch domain and KOW motifs-containing protein
- Complement C1s subcomponent
Sequence:
MARGNQRELARQKNMKKTQEISKGKRKEDSLTASQRKQSSGGQKSESKMSAGPHLPLKAPRENPCFPLPAAGGSRYYLAYGSITPISAFVFVVFFSVFFPSFYEDFCCWI