wanglab/gogpt-training-data huggingface dataset:
Protein: Lck-interacting transmembrane adapter 1 (Lck-interacting molecule) (Q9EQR5)
Organism: Mus musculus (Mouse)
Function: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14610044}; Single-pass type III membrane protein {ECO:0000269|PubMed:14610044}. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
Interaction partners:
- Tyrosine-protein kinase SYK
- B-cell antigen receptor complex-associated protein alpha chain
- B-cell antigen receptor complex-associated protein beta chain
- Proto-oncogene tyrosine-protein kinase LCK
- GRB2-related adapter protein
- GRB2-related adaptor protein 2
- Growth factor receptor-bound protein 2
- Polymeric immunoglobulin receptor
- Immunoglobulin J chain
- Immunoglobulin lambda-like polypeptide 1
Sequence:
MRPPVPSAPLALWVLGCFSLLLWLWALCTACHRKRAQRQQTGLQDSLVPVEMPLLRQTHLCSLSKSDTRLHELHRGPRSSIAPRPASMDLLHPRWLEMSRGSTRSQVPNSAFPPRQLPRAPPAAPATAPSTSSEATYSNVGLAAIPRASLAASPVVWAGTQLTISCARLGPGAEYACIQKHKGTEQGCQELQQKAKVIPATQMDVLYSRVCKPKRRDPRPVTDQLNLQDGRTSLPLGSDVEYEAINLRGQDMKQGPLENVYESIKEMGL
Protein: TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) (Q9H5J8)
Organism: Homo sapiens (Human)
Function: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
Subcellular location: Nucleus {ECO:0000269|PubMed:15520167, ECO:0000269|PubMed:17318177}.
Interaction partners:
- TATA box-binding protein-associated factor RNA polymerase I subunit B
- TATA box-binding protein-associated factor RNA polymerase I subunit A
- TATA box-binding protein-associated factor RNA polymerase I subunit C
- TATA-box-binding protein
- Nucleolar transcription factor 1
- RNA polymerase I-specific transcription initiation factor RRN3
- DNA polymerase beta
- DNA-directed RNA polymerase I subunit RPA43
- DNA-directed RNA polymerase I subunit RPA2
- Transcription termination factor 1
Sequence:
MDKSGIDSLDHVTSDAVELANRSDNSSDSSLFKTQCIPYSPKGEKRNPIRKFVRTPESVHASDSSSDSSFEPIPLTIKAIFERFKNRKKRYKKKKKRRYQPTGRPRGRPEGRRNPIYSLIDKKKQFRSRGSGFPFLESENEKNAPWRKILTFEQAVARGFFNYIEKLKYEHHLKESLKQMNVGEDLENEDFDSRRYKFLDDDGSISPIEESTAEDEDATHLEDNECDIKLAGDSFIVSSEFPVRLSVYLEEEDITEEAALSKKRATKAKNTGQRGLKM
Protein: Anti-sigma F factor (EC 2.7.11.1) (Stage II sporulation protein AB) (P10728)
Organism: Bacillus subtilis (strain 168)
Function: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
Interaction partners:
- Anti-sigma F factor antagonist
- RNA polymerase sigma-F factor
- Stage II sporulation protein E
- Sporulation sigma-E factor-processing peptidase
- Stage II sporulation protein R
- RNA polymerase sigma-G factor
- Stage 0 sporulation protein A
- RNA polymerase sigma-E factor
- Stage V sporulation protein AC
- Stage III sporulation protein D
Sequence:
MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVVSEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPELERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN
Protein: Photosystem I reaction center subunit VIII (PSI-I) (P0C371)
Organism: Oryza sativa (Rice)
Function: May help in the organization of the PsaL subunit.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MMDFNLPSIFVPLVGLVFPAIAMASLFLYVQKNKIV
Protein: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase-1) (Sialyltransferase 8D) (Sialyltransferase St8Sia IV) (Q6KC03)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Neural cell adhesion molecule 1b.
Sequence:
MRLSRKHWTVCTISVLLVLFYKTTDIGRNEVHQKASLTWYLEPSATRLMANGSEKLFGNVLNGLDLGVGWKINATLVSIIRKDILRYLDAERDVSVIKSNFKPGDTIRYVLDRRRTFSVSQTLHSLLPEVSPLKNKTFKTCAVVGNSGILLKSGCGKEIDNHSFVIRCNLAPLEGFADDVGLRSDFTTMNPSVIQRVYGGLREETQQENLIQRLRQLNDSVLWIPAFMVKGGMKHVDTVNELILKHKLKVRTAYPSLRLIHAVRGFWLTNKINIKRPTTGLLMYTMATRFCDEIYLYGFWPFPKDASGNPVQYHYFDGLKYRYFSNAGPHRMPLEFQTLQRLHSKGALKLTTSKCTST
Protein: Chloride channel protein CLC-b (AtCLC-b) (CBS domain-containing protein CBSCLC7) (P92942)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Voltage-gated chloride channel.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Chloride channel protein CLC-f
- Chloride channel protein CLC-e
- Protein NRT1/ PTR FAMILY 5.11
- Protein NRT1/ PTR FAMILY 5.16
- Protein NRT1/ PTR FAMILY 5.12
- Putative DUF21 domain-containing protein At3g13070, chloroplastic
- Probable arabinose 5-phosphate isomerase
- Putative glycerol-3-phosphate transporter 4
Sequence:
MVEEDLNQIGGNSNYNGEGGDPESNTLNQPLVKANRTLSSTPLALVGAKVSHIESLDYEINENDLFKHDWRKRSKAQVLQYVFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGHFLTQERYVTGLMVLVGANLGLTLVASVLCVCFAPTAAGPGIPEIKAYLNGVDTPNMFGATTMIVKIVGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGTDNHRIKWRWLRYFNNDRDRRDLITCGSAAGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLREFIEICNSGKCGLFGKGGLIMFDVSHVTYTYHVTDIIPVMLIGVIGGILGSLYNHLLHKVLRLYNLINEKGKIHKVLLSLTVSLFTSVCLYGLPFLAKCKPCDPSIDEICPTNGRSGNFKQFHCPKGYYNDLATLLLTTNDDAVRNLFSSNTPNEFGMGSLWIFFVLYCILGLFTFGIATPSGLFLPIILMGAAYGRMLGAAMGSYTSIDQGLYAVLGAAALMAGSMRMTVSLCVIFLELTNNLLLLPITMIVLLIAKTVGDSFNPSIYDIILHLKGLPFLEANPEPWMRNLTVGELGDAKPPVVTLQGVEKVSNIVDVLKNTTHNAFPVLDEAEVPQVGLATGATELHGLILRAHLVKVLKKRWFLTEKRRTEEWEVREKFPWDELAEREDNFDDVAITSAEMEMYVDLHPLTNTTPYTVMENMSVAKALVLFRQVGLRHLLIVPKIQASGMCPVVGILTRQDLRAYNILQAFPLLEKSKGGKTH
Protein: Alpha-farnesene synthase (CmTpsDul) (EC 4.2.3.46) (B2KSJ6)
Organism: Cucumis melo (Muskmelon)
Function: Sesquiterpene synthase producing exclusively alpha-farnesene. Associated with the production of sesquiterpenes responsible for the aroma of the fruit.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MSSNISAIPNSLEVIRRSAQFQASVWGDYFLSYHSLSPEKGNKVMEKQTEELKEEIKRELNSTTKDEEPEKLRLIDSIQRLGVCYHFEYEINKILEQLHHITITSKNNGDDHPYNMTLRFRLLRQQGYNISSKSFERFRGKWESSYDKNVEELLSLYEASQLRMRGEEALDEAFRFATAQLEAIVQDPTTDPTVVGEVCQALKWPMYKNLPRLQASHYIGLYSEKPWRNESLPNFAKMDFSKLQKLHQKEIAYISKWWDDYGFAEKLSFARNRIVEGYFFALGIFFEPQLSTARLIMTKIIAIGSVLDDIYDVYGTFEELKLLTLALERWDKSETKKLPKYMKMYYEALLDVFEEIEQEMSQKETTPYCIHQMKEATKELGRVFLVEAKWCKEGYTPTVEEYLDIALISFGHKLLMVTALLGMGSTIATQQIVQWITSMPNILKASAIICRLMNDIVSHKFEQERGHVASAIECYMEQNYMSEHDVLIILGKQIDEFWKDMVENYCVVITEEEVPRGVLMRVLNLTRLFNVIYKDGDGYTQSHGSTKTHIKSLLVDSLPL
Protein: Tail spike protein (TSP) (Gene product 21) (Gp21) (Q0PDK6)
Organism: Bacillus phage SPP1 (Bacteriophage SPP1)
Function: Binds to the host entry receptor YueB and triggers viral DNA ejection. Binding to Yueb. This interaction initiates a cascade of conformational changes at the gp21 C-terminus causing disassembly of the tail spike organization and opening of the cap region formed by the N-terminus of gp21.
Subcellular location: Virion {ECO:0000305|PubMed:22171743}.
Interaction partners:
Sequence:
MRSLSKNIWIMSNFEVLLTTLTGDRDAGGCRYWNGSFEEPLSPGETATYQFYADASHPNSKYVINDNKVIFKEPEQFGGDYRMFTIIDTELGRSEQDGRYIIATCEPAWYELDDDFIENKRPTDKTPQEALDLLLEGTRYEGEVDPDLQMRASDSFYQVSVKEAVIQFFQTWGGYFKDTIEFDGNEITRRVIKSLKRRGAANGVRFEHDKDITSIRRNITGYPKTALYPYGASLEMTDEDGNATGGYTRYIDIKDVVWSKAAGDPVDKPAGQAWIGDPDLLKVFGRPMPDGSLRHRWTRWQNEDITTPEELIEAAYYDLINNVSKAIVNYNVEVAPKNVKLGDTCIILDREFATPIELEADVIKMTYFTDRPEEGATIELGEYLNLDDIERQIGAINDRFKKNEGKWNTGGGITEVTDGAFPDKKPPKPSNITVKSMFQSIFLSWNYDPSSYIAGYRVYASKTPGFTPTDNDIIFEGKMSGYEHKVGNNETWYYRLSTVNYHKTESDMSDQYSAQSERIMNDDILFGAITADKLANLAVTADKISRSFDEGNIFPGSLLKPSQFYDYPNTKHSVTDKTFNELTITQVIDDSTRLRFGISGQNKAPNNIQRMPLEQGQIYTLSFEVKRNNTTDLSYIHLKKPDNTFMLLSSSLKDISAYPSDEFVRVDLQFTAPETSSKFTLGFGGYNRNGNVTPCSFVIRKVQVRKGTEIKDYGYSPYDIMLVDGAIYSDYIQSAAINSAHIADAAIGSAAIQNAAIKNAHLGTAIVDTANIKDAAITSAKIKELSADLITSGTINAINITGSLIRGGRFEPLNESSAYTSYIEGDKIYQRVNTINYGGTPKKTYNDLTITSGGVTMVYGGRDTGTDEPLREMTLRDGSLYMSGNKNDTGYSEIQMYCNDDDVVNAPKSIFRQKLGGVNRMSLHSYYNSVPGSYNVQMDTRNTSIYSHFANGWQLTADGKIMIMSKNGQGIYLDPSNDNVAGQVTMHVGNAGQAGGLIQPVIAGAPHYSITDIHGALQTNMSVMLYQYNFVMPSKGDAYASKYNDIPPPFECENIFMVVPTVFGGYSDHVHATITSQSSSGFRCYVRGTGSSTGILGRTFQVRFLIFYEVN
Protein: Glutathione S-transferase F2 (AtGSTF2) (EC 2.5.1.18) (24 kDa auxin-binding protein) (AtPM24) (GST class-phi member 2) (P46422)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds auxin, endogenous flavonoids and the phytoalexin camalexin and may be involved in regulating the binding and transport of small bioactive natural products and defense-related compounds during plant stress. Binds a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde. In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC). Acts as glutathione peroxidase on cumene hydroperoxide, linoleic acid-13-hydroperoxide and trans-stilbene oxide, but not trans-cinnamic acid or IAA-CoA.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:19174456}. Microsome {ECO:0000269|PubMed:19174456}. Endoplasmic reticulum {ECO:0000269|PubMed:19174456}. Note=Plasma membrane vesicles.
Interaction partners:
- Glutathione S-transferase U19
- Methionine--tRNA ligase, cytoplasmic
- Glutathione S-transferase family protein
- AT5g45020/K21C13_21
- Glutathione S-transferase family protein
- At5g44000
- Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic
- Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial
- Glutathione S-transferase U24
- Glutathione S-transferase U5
Sequence:
MAGIKVFGHPASIATRRVLIALHEKNLDFELVHVELKDGEHKKEPFLSRNPFGQVPAFEDGDLKLFESRAITQYIAHRYENQGTNLLQTDSKNISQYAIMAIGMQVEDHQFDPVASKLAFEQIFKSIYGLTTDEAVVAEEEAKLAKVLDVYEARLKEFKYLAGETFTLTDLHHIPAIQYLLGTPTKKLFTERPRVNEWVAEITKRPASEKVQ
Protein: Cytochrome P450 3A (EC 1.14.14.-) (Q1PCR1)
Organism: Meleagris gallopavo (Wild turkey)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406, ECO:0000256|RuleBase:RU368049}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Microsome membrane {ECO:0000256|ARBA:ARBA00004174, ECO:0000256|RuleBase:RU368049}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004174}.
Interaction partners:
Sequence:
MNLLPFFSIETWILLLIFVALLIAYGTWPFGLFKKLGIPGPRPLPFFGTCLEYRKGFLEFDTECFKKYGKIWGIYDGRQPAVVVMDPQIIKTVLVKECYSTFTNRRRVDLAGELRNAVSLAEDDQWKRLRTVLSPTFTSGKLKEMFPTMKHFGEMLVKNVQKRVEKDSSVPVKDFFGSYSMDVVTSTSFGVNIDSMNNPKSPFVREMQKLTKFDFFDPLFILAFVCPFLTPLMAKMNVSFFPSDAVDFFLRSIDKIKKDREKETHKGRVDFLQMMIESQKSDSDGKNSHKALSDIEVLSQAFIFIFAGYEPTSNTLCYLAYLLALHPDVQQKVVNEIDTILPNKAPLTYEAIMQLDYLDMAVNETLRLYPLGGRIERTCKKDVEINGVTIPKETIVVIPPYTLHRNSEYWPNPEEFRPERFSKENKDNIDPYTYLPFGAGPRNCIGMRFALLTLKVAITSILQHFTFQVCKETQIPLKLLSMGLMTPEKPIILKLVPRTNNAKA
Protein: Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3) (O60896)
Organism: Homo sapiens (Human)
Function: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:32296767}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:32296767}. Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.
Interaction partners:
- Calcitonin receptor
- Pro-adrenomedullin
- Calcitonin gene-related peptide type 1 receptor
- Islet amyloid polypeptide
- Protein ADM2
- Calcitonin gene-related peptide 2
- Receptor activity-modifying protein 2
- Calcitonin
- Guanine nucleotide-binding protein G
- Receptor activity-modifying protein 1
Sequence:
METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL
Protein: Collagen type XIV alpha 1 chain (Q9PSS5)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
VSTRTIAGPPGEPGRPGAPGPQGEQGGPAGPPGYCDPSSCAGYGMGGGYGEPTDQDIPVVQLPHNSYQIYDPEDLYDEFTPVREEMEAVELRSPGISRFRRKIAKRSIKTLEHKRENAKEPSQ
Protein: Phosphatidylinositol transfer protein 1 (PtdIns transfer protein 1) (DdPITP1) (Q9NCL8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10769190}. Golgi apparatus {ECO:0000269|PubMed:10769190}.
Interaction partners:
Sequence:
MLIREFRVVLPLTVEEYRVGQLYSVAKTSSQETSNGEGVEVLVNEPYKEPEHEGQYTHKIYHLGSRLPGWIRALIPSSALKLEEKAWNAYPYCKTVLKSPFLGEKFTFIIESRHAQDNCKTENIHNLSEKELKERTVEVIDITKPIKDPKNYKETEDPTKIRSEKANRGPLEEEKWRESTEMPIMTCYKLVTVEFKYFGFQTKVENFMMGIEFDLFTKFHRQVYCWLDEWFGMSMDDVRAFELKTKEDLKKKLEEKDENKAAEK
Protein: Apolipoprotein F (Apo-F) (Lipid transfer inhibitor protein) (LTIP) (Q13790)
Organism: Homo sapiens (Human)
Function: Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.
Subcellular location: Secreted {ECO:0000269|PubMed:204339, ECO:0000269|PubMed:28935895, ECO:0000269|PubMed:8093033}.
Interaction partners:
- Cholesteryl ester transfer protein
- Apolipoprotein L1
- Apolipoprotein A-II
- Beta-2-glycoprotein 1
- Apolipoprotein A-I
- Apolipoprotein A-IV
- Apolipoprotein M
- Apolipoprotein B-100
- Apolipoprotein C-III
- Clusterin
Sequence:
MTGLCGYSAPDMRGLRLIMIPVELLLCYLLLHPVDATSYGKQTNVLMHFPLSLESQTPSSDPLSCQFLHPKSLPGFSHMAPLPKFLVSLALRNALEEAGCQADVWALQLQLYRQGGVNATQVLIQHLRGLQKGRSTERNVSVEALASALQLLAREQQSTGRVGRSLPTEDCENEKEQAVHNVVQLLPGVGTFYNLGTALYYATQNCLGKARERGRDGAIDLGYDLLMTMAGMSGGPMGLAISAALKPALRSGVQQLIQYYQDQKDANISQPETTKEGLRAISDVSDLEETTTLASFISEVVSSAPYWGWAIIKSYDLDPGAGSLEI
Protein: IA-2 protein tyrosine phosphatase, isoform C (Q9VPV8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004212}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
- Neuroendocrine convertase 2
Sequence:
MPAVGTSCGVPIIMARNVQQRQQHPCTTTEEPKHQRARGTAGHQESATGECQQFWSKQRPPFDQQQQQEDQDPEQDPQQHPSTPQESVHHHRSPRQHELLHHQRKVPPTLPARGRHLISEGARRREVRGCGAGGGGLLCCSLDALSRPAKLLQFGVLLLILLLATHGDLAQAEGNVGCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATMLEELQGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTPPEPEAELDYYEQPAGPAQFYPALRKKQVRESDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDAPSIMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEVDATPELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGPLLGPPSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPERKTAGDVARTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSGEKRELDKDPVVGGGSSSTTTKEPLKEDKAQEAAEEEAPTSSSKAAAAAKKEKEKDKDKEEKQAKDQAKVAEPRTPAKSAKQAKK
Protein: Cytochrome P450 94B3 (EC 1.14.14.48) (Jasmonoyl-L-amino acid 12-hydroxylase) (Jasmonoyl-isoleucine-12-hydroxylase) (Q9SMP5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydroxylase involved in the oxidation of the plant hormone jasmonoyl-L-isoleucine (JA-Ile), a bioactive phytohormone of the jasmonate-mediated signaling pathway. Converts JA-Ile to 12-hydroxy-JA-Ile. Exerts negative feedback control on JA-Ile levels and plays a key role in attenuation of jasmonate responses. Negatively regulates the expression of wound-induced genes TIFY11A/JAZ5, TIFY5A/JAZ8 and TIFY5A/JAZ10. Catalyzes the hydroxylation of jasmonoyl-L-valine (JA-Val), jasmonoyl-L-leucine (JA-Leu) and jasmonoyl-L-phenylalanine (JA-Phe) in vitro. Converts JA-Val, JA-Leu and JA-Phe to 12-hydroxy-JA-Val, 12-hydroxy-JA-Leu and 12-hydroxy-JA-Phe, respectively.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25210037}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- IAA-amino acid hydrolase ILR1-like 6
- IAA-amino acid hydrolase ILR1-like 4
- Allene oxide cyclase 3, chloroplastic
- Jasmonoyl--L-amino acid synthetase JAR1
- Cytosolic sulfotransferase 15
- Allene oxide synthase, chloroplastic
- Allene oxide cyclase 1, chloroplastic
- Allene oxide cyclase 2, chloroplastic
- Allene oxide cyclase 4, chloroplastic
- Lipoxygenase 4, chloroplastic
Sequence:
MAFLLSFLILAFLITIIFFLSSSSTKKVQENTTYGPPSYPLIGSILSFNKNRHRLLQWYTELLRLSPSQTILVPLLGNRRTIITTNPLNVEYILKTNFFNFPKGKPFTDLLGDLLGGGIFNVDGHSWSSQRKLASHEFSTRSLRSFAFEVLKDEVENRLVPVLSTAADVGTTVDLQDVLKRFAFDVVCKVSLGWDPDCLDLTRPVNPLVEAFDTAAEISARRATEPIYAVWKTKRVLNVGSERKLREAIRTVHVLVSEIVRAKKKSLEIGTGAEAKQDLLSRFLAAGHNGEAVRDMVISFIMAGRDTTSAAMTWLFWLLTENDDVERKILEEVDPLVSLGLGFEDLKEMAYTKACLCEAMRLYPPVSWDSKHAANDDVLPDGTRVKRGDKVTYFPYGMGRMETLWGTDSEEFNPNRWFDSEPGSTRPVLKPISPYKFPVFQAGPRVCVGKEMAFMQMKYVVGSVLSRFEIVPVNKDRPVFVPLLTAHMAGGLKVKIKRRSHILNNV
Protein: Carboxylic ester hydrolase (EC 3.1.1.-) (Q9U295)
Organism: Caenorhabditis elegans
Interaction partners:
- Resistance to inhibitors of cholinesterase protein 3
- Vesicular acetylcholine transporter unc-17
Sequence:
MRRRRVLLLLLSTTTFLRVSTAQQDEPKASVVEVQTKLGTVRGTESDHGNKRVRSFLGVPFAEPPINEHRFKKPTPARPWNGTISANTLSPACFQGRDSYDPTFWGSEMWNANTPVSEDCLYVNIWAPADAYNLTVLVWLFGGGFWYGSPSLLLYDGKELATRGNVIVVNINYRVGPFGYLFLDHEDVPGNMGMLDQQLALYWIRDHIFSFGGNPARISLVGESAGAASIVAHLIAPASKGLFQNGILQSGSLDNKWSMDSPKRAKQKSTALADLVGCNQTKITDQTACLRNTPAQLLIDNIWNVGLNFLEFPFAIVSKDQNFFKHLDGFIALREGTYSTDVNLMFGINHDEGNFWNIYNLAKFFDKQSVKPGLDRDEFHECVDTAFAVQPELVRTAAKYVYSDPKCTDPKKKTDFYTEQVNQMVGDYFFTCDSIWFAHNYPKMAGNQSNVFVYYFDQPSSANPWPKWTGVMHGYEIEYVFGVPLHNTTAGYTKEEMDVSEKVIDFWTTFANTGVPSLRKRAVGTTQKIKWDRYDGTDHTTWMNIKTGSFRMIQEIKKVECDLWRNAKDMEYSAYKEELATTSSSTLTQYTIYLILLSAFQLVFNFF
Protein: Bromodomain-containing 3a (Bromodomain-containing protein 3a) (F1QQP6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- GATA-binding protein 1a.
- Cyclin-dependent kinase 9
- Cyclin-T2b
Sequence:
MSAVTSATPEPPAAANPPPPEVINPTKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAVKLGLPDYHKIIKNPMDMGTIKKRLESVYYYSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVALMPQEEVELLPPAPKGKGRKPAGPGQQDGAVSTGSPTSVFPGATSPSSQTAVVSPAPVPAITPSIPAVQNTTAAAVIPSMPPSQPTVKKKGVKRKADTTTPTTSAITASRSQSPTPILEGKQSKVAARRESTGRPIKPPKKDFEDGELGVHGGKKGRLSEQLKYCDVILKEMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKKKMDSREYQDAQTFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPVEVPGAGGVGGAGVVSKSTVSSESSGDSSTSDSSDSEEERATRLAELQEQVGAEQCISLEHPIGSRKGIKNGCTKNNQLKAVHEQLAALSQAPVSKPKKKKEKKEKDKKKKENKHNKSKPEEKAKPGQPPKPAQQKKGPTRKANSTVPGNRQPKKGGRGPGYESDEEMSLPMTYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPSTLRELERYVKSCLQKKQRKPPQKGGSGPSRLSGSSSSSDSGSSSSSGSTSDSSDSD
Protein: Replication protein A 70 kDa DNA-binding subunit B (AtRPA70B) (AtRPA1-5) (Replication factor A protein 1B) (Replication protein A 1B) (AtRPA1B) (Q9SD82)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions (By similarity). Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Replication protein A 32 kDa subunit A
- Replication protein A 32 kDa subunit B
- Replication protein A 70 kDa DNA-binding subunit D
- Replication protein A 70 kDa DNA-binding subunit C
- Replication protein A 70 kDa DNA-binding subunit A
- DNA primase
- DNA replication licensing factor MCM2
- F5O8.30 protein
- F11M21.26 protein
- Expressed protein
Sequence:
MENSVTQDGIATVLANQSLDSSSVRPEIVVQVVDLKPAGNRYTFSANDGKMKIKAMLPATLTSDIISGKIQNLGLIRLLEYTVNDIPGKSEEKYMLITKCEAVASALDSEIKAEIKASTGIMLKPKHEFVAKSASQIINEQRGNAAPAARMAMTRRVHPLVSLNPYQGSWTIKVRVTNKGVMRTYKNARGEGCVFNVELTDEEGTQIQATMFNAAARKFYDRFEMGKVYYISRGSLKLANKQFKTVQNDYEMTLNENSEVEEASNEEMFTPETKFNFVPIDELGTYVNQKDLIDVIGVVQSVSPTMSIRRKNDNEMIPKRDITLADETKKTVVVSLWNDLATGIGQELLDMADNHPVIAIKSLKVGAFQGVSLSTISRSNVVINPNSPEATKLKSWYDAEGKETSMSAIGSGMSSSANNGSRSMYSDRVFLSHITSNPSLGEEKPVFFSTRAYISFIKPDQTMWYRACKTCNKKVTEAMDSGYWCESCQKKDQECSLRYIMAVKVSDSTGETWLSAFNDEAEKIIGCTADDLNDLKSEEGEVNEFQTKLKEATWSSHLFRISVSQQEYNSEKRQRITVRGVSPIDFAAETRLLLQDISKNKTSQ
Protein: UDP-glucuronosyltransferase 2B37 (UDPGT 2B37) (EC 2.4.1.17) (17-beta-hydroxysteroid-specific UDPGT) (UDP-glucuronosyltransferase R-21) (UDPGTr-21) (UDPGTr-5) (P19488)
Organism: Rattus norvegicus (Rat)
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. About 30-fold less active than Ugt2b17 toward testosterone and dihydrotestosterone.
Subcellular location: Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Cytochrome P450 1A2
- Cytochrome P450 1A1
- Cytochrome P450 2E1
- Catechol O-methyltransferase
- Transmembrane O-methyltransferase homolog
- Beta-glucuronidase
- Estrogen sulfotransferase Ste2
- Cytochrome P450 1B1
- Aldo-keto reductase family 1, member C1
- Aromatase
Sequence:
MPGKWIFALLLLQISFCLRSAKCGKVLVWPMEFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKKSPDLKFETFPTSVSKDELEKYFIKLADAWTYELQRDTCLSFSPLLQNMMDEFSDYYLSVCKDAVSNKQLMAKLQESKFDVLLSDPVAACGELIAEVLHIPFLYSLRASPGHKIEKSSGRFILPPSYVPVILSGLGGQMTFIDRVKNMICMLYFDFWFHMFNAKNWDPFYTEILGRPTTLAETMGKAEMWLIRSYWDLEFPHPTLPNVDYIGGLQCKPAKPLPKDIEDFVQSSGEHGVVVFSLGSMVSSMTEEKANAIAWALAQIPQKVLWKFDGKIPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEVINNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLRPLGHNLPWYQYHSLDVIGFLLACLAVIAALAVKCFLFIYRFFAKKQKKMKNE
Protein: Rab8 (Ras-related protein Rab-8A) (G5EFC1)
Organism: Caenorhabditis elegans
Interaction partners:
- Exocyst complex component 6
- Rab GDP dissociation inhibitor
- GDP/GTP exchange factor Sec2 N-terminal domain-containing protein
- Exocyst complex component 4
- Exocyst complex component 5
- Exocyst complex component 3
- Intraflagellar transport protein 20 homolog
- RAB family
- Guanine nucleotide exchange protein smcr-8
- Exocyst complex component 1
Sequence:
MAKTYDYLFKLLLIGDSGVGKTCVLFRFSDDSFNNSFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIILVYDITNERSFENIKNWIRNIEEHAASDVERMIIGNKCDIEERREVSRDRGEQLAIEYGTKFLETSAKANLNIDEAFFTLARDIKSKMEQNEMRAGGSVSNTGRVNVGGSGTQKKSFFSNWSCNLL