wanglab/gogpt-training-data huggingface dataset:
Protein: Probable ATP-dependent DNA helicase HFM1 (EC 3.6.4.12) (D3Z4R1)
Organism: Mus musculus (Mouse)
Function: Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.
Interaction partners:
- MutS protein homolog 4
- Pre-mRNA-processing-splicing factor 8
- Meiotic recombination protein SPO11
- Structure-specific endonuclease subunit MUS81
- Pre-mRNA-processing factor 6
- Activating signal cointegrator 1 complex subunit 2
- U4/U6.U5 tri-snRNP-associated protein 1
- Pre-mRNA-splicing factor SYF1
- SNW domain-containing protein 1
- Splicing factor 3B subunit 1
Sequence:
MPKSDDCFFSMDNLFFSSPDETENFPVKEKSLDWFLPPAPLISEIPDIQELEEEIESYKLLGKGKMPRMLTSNLKIINEDTNCISPTQKIHFSYNVHEQDYLNLGGSNNNDMSHVAGKLMYGSSQKYKNHMGAKSPSARSSPGDTKLHDVAEDRQGTSAFKKRLSRTCDSEHDCDYADGSLNLSSHISPVKLTQTKISKENAWTCSNSKQKRQYSTNKFKANDAFSASGIGKDIFKAPSFPAASQPHDIQGITPNGLGSLKAVTEIPAKFRNIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNMKIVYMAPIKALCSQRFDDWKEKFGPVGLNCKELTGDTVMDDLFEIQHANIIITTPEKWDSVTRKWRDNSFIQLVRLFLIDEVHVIKDENRGPTLEVVVSRMKTVQSLSRDLESASPVPVRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSSQTEFKFDLALNYKVYSVIRTYSDQKPTLVFCSTRKGVQQAASVLVKDAKFIISVEQKLRLQKSAYSIRDSKLKDTLVYGVGYHHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIKSTMHYSGGVFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTREKYVQMLACNDTVESSLHRHLIEHLNAEIVLHTITDVNIALDWIRSTMLYIRALKNPSHYGFSSGLNKDGIEAKLQELCLKNLKDLSSLDLIKMDEDVNFKPTEAGRLMAWYYITFETVKKFCAISGKETLLDLISMISSCNEFLDVQLRISEKRILNTLNKDPNRITIRFPMAERIKTREMKVNCLIQAQLGCIPIQDFALTQDTVKIFRNGSRIARWLSDFVAAQEKKFAVLLNSVILTKCFKCKLWENSKHVSKQLDKIGISLSNTMVNAGLTSFKKIEEANARELELILNRHPPFGTQIKEAVAHLPKYELEVEQIARYSDIKAEILVTIILRNFEQLQTKRTAPDFHYATLIIGDADNQVVFKHKIMDSVLLKSGNWVKKIDVKRALISEDLSINLISSDYVGLDIHQKFTVFYFGPRKFVNETAMERSSETDISHSDYSGRATATGSSKGMATCKKPGNRECHHHCKNKHACGHDCCKIGVAQKPEVKESAMSSYLSDLKSRDAVSSLPLAKRLKIQMNKSQNVDLKEFGFTPRPSLSSISRSEYLNTPELSILEQRNQHEIYGKVQQGPSEYRDKEVLGVNLELGNEVWDDFDDESLIEVMSLSADAEKMAASGFGDTRDSSLGGSKLPFQKSSSRFQRDNSNSFASSPGKPDAYLRDCSRSSFGLSSVAEIPQRAENASLANLQERRPLTLSPVIERMCFAHSKKTPQSPKFKEVDIFIGNSGSKKEIDLSKYYPDDAAEEMKALLGIFNGIF
Protein: Serine/threonine-protein kinase chk-1 (EC 2.7.11.1) (Q9N3Z3)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Delays cell-cycle reentry of the Z2 and Z3 primordial germ cells in response to transcription-induced DNA damage as they emerge from cell cycle arrest in L1 larvae. Essential for embryogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:26073019}. Nucleus {ECO:0000250|UniProtKB:O61661}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:26073019}. Note=The Ser-344 phosphorylated form colocalizes with P granules in a perinuclear manner in embryonic germline precursor cells and in Z2/Z3 primordial germ cells in L1 stage larvae. {ECO:0000269|PubMed:26073019}.
Interaction partners:
- DNA repair protein RAD51 homolog
- Serine/threonine-protein kinase ATR
- Protein hsr-9
- Claspin
- DNA replication licensing factor mcm-4
- Exonuclease 1
- CDT1 Geminin-binding domain-containing protein
- WD_REPEATS_REGION domain-containing protein
- Protein timeless homolog
- Checkpoint protein
Sequence:
MSAASTTSTPAAAAVAPQQPESLYRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKSKDFIDNIRKEYLLQKRVSAVGHDNVIRMIGMRNDPQFYYLFLEYADGGELFDKIEPDCGMSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMATLYRNKGEERLLDLSCGTIPYAAPELCAGKKYRGPPVDVWSSGIVLIAMLTGELPWDRASDASQSYMGWISNTSLDERPWKKIDVRALCMLRKIVTDKTDKRATIEQIQADPWYQHNFGQVETPNGRPLKRARNNDENITCTQQAECSAKRRHLETPNEKSTLAERQNASFSQPTKTEDLLLTQHIDMSQTNSNLLQRMVCRMTRFCVVTDIRSTYQKVARASEHAGFGVRETDDYRLLVTWREVSMMVSLYTMGDIPDKPRVMVDFRRSRGDGIQFKKMFMDVRNRMHEWICTDGNNWLANLGYVPRNPQIVNGGGVNVEHSASSINVDV
Protein: SH2 domain-containing protein (Q22497)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKPPICRRMSLPPVLAKKEGERIQVPEGGELVCYRNQEDQHLFLKIEYSRETMIKLSSSVFCYARPTGLKEVSDELPELLGLPHSIPLTDSPPNFECLPEPLAHVSGCNSHFSMNHPPPLLSPLRGPVTEADEAMRTLSSHRELQKRLQNMSMRGELSPSGCLVDSCDTPAIRQIRNPQFT
Protein: F-box only protein 50 (NCC receptor protein 1) (Q9PTD4)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
Sequence:
MAVWKQKCDSEWQLAANGAPLPDDVDWKSVYEKKPLERNLLKNPSPHGLTHDTPPPEREVTGERPDPDLPPQFEPTGDFSGCSTSIEQLPLDSSGIPPGDVDCYLPTFSWFSLEQRVELKAEGLWDKLLDKFQPDIAIEDCYEESQLHASIYELHVKLLAADGQTVIKEHTCSPTEDLENYSHNWKQVSHVFSGYGPGVRYVHFQHKVKTKFMVEFFGTMVTGSSVVVKATKSSP
Protein: RE15719p (Q7YU32)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMHKLKYRDKLKWLLALLVLIGTCFIQTRGQTRDPRFYSRPGVDYHWPNPGDPDYRTYTFNDRRYGHYQPNGYGANYPGRNPPGQYPQGMPNEDRFRFDPNDPNARTQFPGVLAGWREDLQGKQRRDSLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTGNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVIGVLVPTYPPTTEYWWEPKEPLQIAFWSMSVACFFLIVLVVICCIMWRNAKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHMVTNHHALRSRDNIYEYRDSPSTKTLASKAHTDTTSLRSPSSLAMTQKSSSQASLKSGISLKETNGHLVKQSERAATPRSQQNGSTAKVASPPVEEKRLLQPLSSTPVTQLQAEPAKRVPTAASVSGSSRSTTPVPSARSTTTHTTTATLSSQPAAQPRRTHLVEGVPQTSV
Protein: Arachidonate 5-lipoxygenase-activating protein (FLAP) (MK-886-binding protein) (P30355)
Organism: Mus musculus (Mouse)
Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity).
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:19075240}; Multi-pass membrane protein {ECO:0000269|PubMed:19075240}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Polyunsaturated fatty acid 5-lipoxygenase
- Leukotriene A-4 hydrolase
- Arachidonate 12-lipoxygenase, 12R-type
Sequence:
MDQEAVGNVVLLALVTLISVVQNAFFAHKVEHESKAHNGRSFQRTGTLAFERVYTANQNCVDAYPTFLVVLWTAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSFAGILNHYLIFFFGSDFENYIRTVSTTISPLLLIP
Protein: Probable dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109) (P9WN05)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins (Probable). Mannosylates an artificial substrate, probably on a Thr residue, upon expression in M.smegmatis. Glycosylation probably requires the Sec-translocation system.
Subcellular location: Cell membrane {ECO:0000305|PubMed:16081738}; Multi-pass membrane protein {ECO:0000305|PubMed:16081738}.
Interaction partners:
- Ribosomal RNA small subunit methyltransferase I
Sequence:
MTARPPESCVLAKDRPEEPVVPVVSPGPLVPVADFGPLDRLRGWIVTGLITLLATVTRFLNLGSLTDAGTPIFDEKHYAPQAWQVLNNHGVEDNPGYGLVVHPPVGKQLIAIGEAIFGYNGFGWRFTGALLGVVLVALVVRIVRRISRSTLVGAIAGVLLICDGVSFVTARTALLDGFLTFFVVAAFGALIVDRDQVRERMHIALLAGRSAATVWGPRVGVRWWRFGAGVLLGLACATKWSGVYFVLFFGAMALAFDVAARRQYQVQRPWLGTVRRDVLPSGYALGLIPFAVYLATYAPWFASETAIDRHAVGQAVGRNSVVPLPDAVRSLWHYTAKAFHFHAGLTNSAGNYHPWESKPWTWPMSLRPVLYAIDQQDVAGCGAQSCVKAEMLVGTPAMWWLAVPVLAYAGWRMFVRRDWRYAVVLVGYCAGWLPWFADIDRQMYFFYAATMAPFLVMGISLVLGDILYHPGQGSERRTLGLIVVCCYVALVVTNFAWLYPVLTGLPISQQTWNLEIWLPSWR
Protein: Interleukin-9 (IL-9) (Cytokine P40) (T-cell growth factor P40) (P15248)
Organism: Homo sapiens (Human)
Function: Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. Affects intestinal epithelial permeability and adaptive immunity. In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5.
Subcellular location: Secreted.
Interaction partners:
- Interleukin-9 receptor
- Cytokine receptor common subunit gamma
- Interleukin-7
- Tyrosine-protein kinase JAK3
- Interleukin-4
- Interleukin-5
- Interleukin-2
- Interleukin-6
- Interleukin-15
- Tyrosine-protein kinase JAK1
Sequence:
MLLAMVLTSALLLCSVAGQGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIPSDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI
Protein: Glutamate dehydrogenase 1, mitochondrial (EC 1.4.1.3) (Q8JHY1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MYRYFGELLTRGASSALASGCVESALPVTASLMRVRHYSEVVGEKDADDPNFFKMVEGFFDRGANIVEDKLVEDLKNKETPVQKRHRVRGILKIIKPCNHILSVSFPIKRDNGEWEVIEGYRAQHSQHRTPCKGGIRYSTEVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINVKNYTDNELEKITRRFTIELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYANTMGHHDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEAAYMSQLGLSPGFTDKTFVIQGFGNVGMHSMRYLHRFGAKCVGVGEMDGNIWNPNGIDPKELEDYKLQHGTIVGFPNSTPYEGSILEADCDILIPAASEKQLTRNNAHKIKAKIIAEGANGPTTPDADKIFLERNIMVIPDMYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGAIPVVPTSEFQARIAGASEKDIVHSGLAYTMERSARQIMRTANKYNLGLDLRTAAYVNAIEKVFKVYNEAGLTFT
Protein: FO synthase [Includes: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (EC 4.3.1.32); 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase (EC 2.5.1.147)] (P9WP77)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
Interaction partners:
- Multidomain regulatory protein Rv1364c
- Phosphoenolpyruvate transferase
- Phosphoenolpyruvate guanylyltransferase
- F420-dependent glucose-6-phosphate dehydrogenase
- Bifunctional F420 biosynthesis protein FbiB
- Deazaflavin-dependent nitroreductase
- Thiazole synthase
- Phosphomethylpyrimidine synthase
- Thiamine-phosphate synthase
- F420-dependent hydroxymycolic acid dehydrogenase
Sequence:
MPQPVGRKSTALPSPVVPPQANASALRRVLRRARDGVTLNVDEAAIAMTARGDELADLCASAARVRDAGLVSAGRHGPSGRLAISYSRKVFIPVTRLCRDNCHYCTFVTVPGKLRAQGSSTYMEPDEILDVARRGAEFGCKEALFTLGDRPEARWRQAREWLGERGYDSTLSYVRAMAIRVLEQTGLLPHLNPGVMSWSEMSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDPAVRLRVLTDAGRLSIPFTTGLLVGIGETLSERADTLHAIRKSHKEFGHIQEVIVQNFRAKEHTAMAAFPDAGIEDYLATVAVARLVLGPGMRIQAPPNLVSGDECRALVGAGVDDWGGVSPLTPDHVNPERPWPALDELAAVTAEAGYDMVQRLTAQPKYVQAGAAWIDPRVRGHVVALADPATGLARDVNPVGMPWQEPDDVASWGRVDLGAAIDTQGRNTAVRSDLASAFGDWESIREQVHELAVRAPERIDTDVLAALRSAERAPAGCTDGEYLALATADGPALEAVAALADSLRRDVVGDEVTFVVNRNINFTNICYTGCRFCAFAQRKGDADAYSLSVGEVADRAWEAHVAGATEVCMQGGIDPELPVTGYADLVRAVKARVPSMHVHAFSPMEIANGVTKSGLSIREWLIGLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSLWIEIVTTAHEVGLRSSSTMMYGHVDSPRHWVAHLNVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPSHRDNRAVHALARIMLHGRISHIQTSWVKLGVRRTQVMLEGGANDLGGTLMEETISRMAGSEHGSAKTVAELVAIAEGIGRPARQRTTTYALLAA
Protein: Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28) (Q64028)
Organism: Mus musculus (Mouse)
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Polycomb complex protein BMI-1
- E3 ubiquitin-protein ligase RING2
- Polycomb group RING finger protein 2
- E3 ubiquitin-protein ligase RING1
- Polycomb protein SCMH1
- Chromobox protein homolog 2
- Polyhomeotic-like protein 2
- Chromobox protein homolog 7
- E3 SUMO-protein ligase CBX4
- Chromobox protein homolog 8
Sequence:
METESEQNSSSTNGSSSSGASSRPQIAQMSLYERQAVQALQALQRQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAASRQASSPNSSTAQQQTATTQASMNLATTSAAQLISRSQSVSSPSATTLTQSVLLGNTTSPPLNQSQAQMYLRPQLGNLLQVNRTLGRNVPLASQLILMPNGAVAAVQQEVPPAQSPGVHADADQVQNLAVRNQQASAQGPQMPGSTQKAIPPGASPVSGLSQTSSQALAVAQASSGASGQSLNLSQAGGGSGNSLPGSMGPGGGGQAPGGLGQLPSSGLTGGSCPRKGTGVVQPLPAAQTVTVSQGSQTEAESAAAKKAEADGSGQQSVGMNLTRTATPAPSQTLISSATYTQIQPHSLIQQQQQIHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQQQQQQQQQQQQQQQQQQQQGTTLTAPQPPQVPPTQQVPPSQSQQQAQTLVVQPMLQSSPLTLPPEPTSKPPIPIQSKPPVAPIKPPQLGAAKMSATQQPPPHIPVQVVGTRQPGSAQAQALGLAQLAAAVPTPRGITGAVQPGQAHLASSPPSSQAAPGALQECPPALAAGMTLAPVQGTAHVVKGGPTASSPVVAQVPAAFYMQSVHLPGKAQTLAVKRKAESEEERDDLSALASVLPTKASPAAESPKVIEEKNSLGEKAEPVASLNANPPNSDLVALAPTPSAPPPTLALVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQFLKETKKPLQAGLPTGLNESQPSGPLGGDSPSVELEKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEFQEASYARVRRRGPRRSSSDIARAKIQGKRHRGQEDSSRGSDNSSYDEALSPTSPGPLSVRAGHGERDLGNTITTPSTPELQGINPVFLSSNPSQWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINVLKET
Protein: Metal regulatory transcription factor 1 isoform X2 (Metal-regulatory transcription factor 1) (A0A0B5H7U7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGENGPLSETAMLFEDEEEDVDKLGREEEDEDKMANFDKDGNMISGPSSSSGTVYDRTTVLIEQDPIRLDEEGEEDGMTFLPEGEGDEGSLAFMGDPDGMSQGYIHHTISPDQIQFIINPGSTPMPRNIEGATLTLHSECPETKQREVKRYQCLFEGCTRTYSTAGNLRTHQKTHRGEYTFVCNQQGCGKAFLTSYSLKIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCTKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGEKPFFCPSDGCEKTFSSQYSLKSHIRGHDKGPSFTVSSHPLSEDANHSLCLSDLSLISTDSELQENHNSQGLDLNSVTPIRIFELMFQSPENSVSEDDPKPTESLAESFGLEPSPQTAPADASTHPAFPQPPPSTCSSSCSITAPAQDAQTPPTTQQAPPPAVSSSSQTSSFPSAPPSSSQPAEVSSPSAPSATQHYMMAQPVSSPSAASVSSVPAGTAEVTAAVTHTVPLAAPPTISIAPTLGLQPSLVMSDQNLQWILSSAASAQQNPEQQGPKVEKVFFTTAIPVGGNSGNAVQQIGLSLPVIIIKQEESCQCHCACRDSAKDKSTSSSQDKTKNTSPPPPPAPPPPPPALPKEPPSCCPSKPHTQPQQDLPTAPLTPNPPTDALGSMDVSDLLSPETTANIEALLMVADGFSMADGGGSGAP
Protein: Interleukin-21 (F4MJ51)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Fibronectin type-III domain-containing protein
- Interleukin 21 receptor, tandem duplicate 1
- IL-21 receptor
Sequence:
MASGKENVFTHSITFHSFPISQTWFSCVLMDKYIAITCVLVDADKGERILKLTEVIKELKALNRTVTHNSVMSNAPSMDTEECCSQSALKCFRAMVPHLKAKNKTLQRKVIKNLNNRMILGSLDSCSQEEREKTVCQGCDSYPKDSQKCVQQLESLLQKAISRLA
Protein: Myosin-IIIa (EC 2.7.11.1) (Q8NEV4)
Organism: Homo sapiens (Human)
Function: Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity).
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm {ECO:0000269|PubMed:25822849}. Cell projection, filopodium tip {ECO:0000269|PubMed:25822849, ECO:0000269|PubMed:29880844}. Cell projection, stereocilium {ECO:0000269|PubMed:29880844}. Note=Increased localization at the filodium tip seen in the presence of MORN4. {ECO:0000269|PubMed:25822849}.
Interaction partners:
- Espin
- Espin-like protein
- Whirlin
- Unconventional myosin-VI
- Unconventional myosin-Ia
- Unconventional myosin-Ic
- Epidermal growth factor receptor kinase substrate 8
- Epidermal growth factor receptor kinase substrate 8-like protein 2
- CD2-associated protein
- Ras-related C3 botulinum toxin substrate 3
Sequence:
MFPLIGKTIIFDNFPDPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEFIGIHQCMGGTEKARRERIHTKKGNFNRPLISNLKDVDDLATLEILDENTVSEQLEKCYSRDQIYVYVGDILIALNPFQSLGLYSTKHSKLYIGSKRTASPPHIFAMADLGYQSMITYNSDQCIVISGESGAGKTENAHLLVQQLTVLGKANNRTLQEKILQVNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEKNFHIFYYIYAGLAEKKKLAHYKLPENKPPRYLQNDHLRTVQDIMNNSFYKSQYELIEQCFKVIGFTMEQLGSIYSILAAILNVGNIEFSSVATEHQIDKSHISNHTALENCASLLCIRADELQEALTSHCVVTRGETIIRPNTVEKATDVRDAMAKTLYGRLFSWIVNCINSLLKHDSSPSGNGDELSIGILDIFGFENFKKNSFEQLCINIANEQIQYYYNQHVFAWEQNEYLNEDVDARVIEYEDNWPLLDMFLQKPMGLLSLLDEESRFPKATDQTLVEKFEGNLKSQYFWRPKRMELSFGIHHYAGKVLYNASGFLAKNRDTLPTDIVLLLRSSDNSVIRQLVNHPLTKTGNLPHSKTKNVINYQMRTSEKLINLAKGDTGEATRHARETTNMKTQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNSERQARKYDKEKVLLQLRYTGILETARIRRLGFSHRILFANFIKRYYLLCYKSSEEPRMSPDTCATILEKAGLDNWALGKTKVFLKYYHVEQLNLMRKEAIDKLILIQACVRAFLCSRRYQKIQEKRKESAIIIQSAARGHLVRKQRKEIVDMKNTAVTTIQTSDQEFDYKKNFENTRESFVKKQAENAISANERFISAPNNKGSVSVVKTSTFKPEEETTNAVESNNRVYQTPKKMNNVYEEEVKQEFYLVGPEVSPKQKSVKDLEENSNLRKVEKEEAMIQSYYQRYTEERNCEESKAAYLERKAISERPSYPVPWLAENETSFKKTLEPTLSQRSIYQNANSMEKEKKTSVVTQRAPICSQEEGRGRLRHETVKERQVEPVTQAQEEEDKAAVFIQSKYRGYKRRQQLRKDKMSSFKHQRIVTTPTEVARNTHNLYSYPTKHEEINNIKKKDNKDSKATSEREACGLAIFSKQISKLSEEYFILQKKLNEMILSQQLKSLYLGVSHHKPINRRVSSQQCLSGVCKGEEPKILRPPRRPRKPKTLNNPEDSTYYYLLHKSIQEEKRRPRKDSQGKLLDLEDFYYKEFLPSRSGPKEHSPSLRERRPQQELQNQCIKANERCWAAESPEKEEEREPAANPYDFRRLLRKTSQRRRLVQQS
Protein: Peptidase C51 domain-containing protein (Q57ZC4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- ATP-grasp domain-containing protein
Sequence:
MVSLNRKQKFQLAVPATLLLFLFVYVLLGGGSTQKSKRHGMHMDFNPLEHCNAPMDSVVGYSSDVPSMSNCHRHWLSETYAYTTIGYPHEVMKKMPYGSEWKRAPTGLCWTADEFVARYLLHTRGIFVYFGGSRHDLYWENLKFFGSSGMHRLYERINFENKVEVTTTKRRKRHTPLVGDVVVWDSDYKAYFPRGHVAVVVKVEDDVSAAGGEAALRELKKERRQPSLVYIAEQNFDNKNWEGRNFSRVLKFTWMRGDRASLEDPDGPPLMGHVRVGKLLEDASFFGDL
Protein: 3-ketosteroid-9-alpha-monooxygenase, oxygenase component (3-ketosteroid-9-alpha-hydroxylase, oxygenase component) (KSH) (Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase) (EC 1.14.15.30) (Rieske-type oxygenase) (RO) (F1CMX0)
Organism: Rhodococcus rhodochrous
Function: May be involved in the degradation of cholic acid, a steroid acid found predominantly in the bile. In vitro, catalyzes the introduction of a 9alpha-hydroxyl moiety into the ring B of 3-ketosteroid substrates such as 1,4-androstadiene-3,17-dione (ADD), 4-androstene-3,17-dione (AD), 4-androstene-17beta-ol-3-one (testosterone), 4-pregnene-3,20-dione (progesterone), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 23,24-bisnorcholesta-4-ene-22-oate, 3-oxo-23,24-bisnorcholaesta-1,4-dien-22-oate (1,4-BNC), 23,24-bisnorcholesta-1,4-diene-22-oate and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA). KshA1 has the highest specificity for steroids possessing an isopropionyl side chain at C17.
Interaction partners:
- 3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component
- Unannotated protein.
- Unannotated protein.
- Unannotated protein.
- Unannotated protein.
- Unannotated protein.
- 3-ketosteroid-9-alpha-monooxygenase, oxygenase component
- 3-ketosteroid-9-alpha-monooxygenase, oxygenase component
- Unannotated protein.
- Unannotated protein.
Sequence:
MSLGTSEQSEIREIVAGSAPARFARGWHCLGLAKDFKDGKPHSVHAFGTKLVVWADSNDEIRILDAYCRHMGGDLSQGTVKGDEIACPFHDWRWGGNGRCKNIPYARRVPPIAKTRAWHTLDQDGLLFVWHDPQGNPPPADVTIPRIAGATSDEWTDWVWYTTEVDTNCREIIDNIVDMAHFFYVHYSFPVYFKNVFEGHVASQFMRGQAREDTRPHANGQPKMIGSRSDASYFGPSFMIDDLVYEYEGYDVESVLINCHYPVSQDKFVLMYGMIVKKSDRLEGEKALQTAQQFGNFIAKGFEQDIEIWRNKTRIDNPLLCEEDGPVYQLRRWYEQFYVDVEDVAPEMTDRFEFEMDTTRPVAAWMKEVEANIARKAALDTETRSAPEQSTTAG
Protein: Asparagine--tRNA ligase (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (P54263)
Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Subcellular location: Cytoplasm.
Interaction partners:
Sequence:
MRVFIDEIARHVDQEVELRGWLYQRRSKGKIHFLILRDGTGFLQATVVQGEVPEAVFREADHLPQETALRVWGRVREDRRAPGGFELAVRDLQVVSRPQGEYPIGPKEHGIDFLMDHRHLWLRHRRPFAVMRIRDELERAIHEFFGERGFLRFDAPILTPSAVEGTTELFEVELFDGEKAYLSQSGQLYAEAGALAFAKVYTFGPTFRAERSKTRRHLLEFWMVEPEVAFMTHEENMALQEELVSFLVARVLERRSRELEMLGRDPKALEPAAEGHYPRLTYKEAVALVNRIAQEDPEVPPLPYGEDFGAPHEAALSRRFDRPVFVERYPARIKAFYMEPDPEDPELVLNDDLLAPEGYGEIIGGSQRIHDLELLRRKIQEFGLPEEVYDWYLDLRRFGSVPHSGFGLGLERTVAWICGLAHVREAIPFPRMYTRMRP
Protein: Appl2 (DCC-interacting protein 13-beta) (B2XCM0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Cytoplasmic vesicle, phagosome {ECO:0000256|ARBA:ARBA00004262}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004220}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPAVHHKLLLEEALQDSPQTRSLLSVFEEDAGTLTNYTNQLLQSMQRVFGAQNEMALATEQLSKQLLEYEKQNFALAKGDEEVINTLQQFAKSVEELNALHSELSTQIADKMVFPMVQFREKDLTEISTLKEIFSIATDEHEAAMVKYSRLPKKRENEKVKAEVVREVAYSRRKQHQAAMQYYCALNALQYRKRVAMLEPMLGYTHAQINFFKKGMELVSKKLDSFLNSVSNMNESIESQLEIDAEVMRSSQRELLSVDDSVYMPDHDQAAVSRALIQKAGYLNIRNKTGLVTTAWDRLFFFTQGGNLMCQPRGAVAGGMVLDLDNSSVMAVDCEDRRYCFQITSPNGKTSLILQAESKREYEEWICTLNNISRQIYLTDNPEAVAIKLHQTALQAVTPITSFEKRAEGSPNPDRAKPGGLPVTSQEAEKSSVSLEPEDLIVPGTPIQFDIMLPASEFLDQNRAGARRTNPFGETEEDDDESDTHDSLLQQVFAVRFLGSMAVRSGHTQEVIYEAMRQVLAARAIHNIFKTTESHLMISSSCIRLIDPQTQVTKISFQLQEVSEFAAHQENERLMGFVVRSSAEDDEPSFSVFVFESNTEGEKICYTINLAKEIADARKDPEALAQLMKSMPLTNDGKFLLLDNETGDTAETAGQEQQESEA
Protein: Liprin-alpha, isoform C (M9PC73)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MWNMMCDVMPTISEDSISQRSSQFSGEDANFEQLMVSMLDERDKLMDSLREAQERLNETENKLRDVEKERDSLQRQINANLPQEFATLTKELTQARETLLERDEEIGELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAAAQSGVSSEVEVLKALKSLFEHHKALDEKVRERLRLSIEKNNMMEEELSSAKEELAQYKAGVVPAGVGSGSGAGSAATTAGGGGAENGLKEKMAGVGGSGGVNGEANELNDYAAKTHELQTIIEKQTSELSQWQRRVSDLNNKISELEENMSRVQKEHCKAQDQCAKLQRDLRENVAQKEDQEERITTLEKRYLNAQRESTSLHDLNEKLEQELRHKEAQLKAQERHGSAEDRIRGLETNLDEKTNEVVRLNQRLKMNEEHNLRLSSTVDKLLSESNERLQVHLKERMHALDEKNALTQELEKARKVAEELHHEKSEIMKELSKTRLEIENFKRQLLQQEIAYNIQQTEALTRSLSPSSVVDPSGAFSRSNSHASFETHSLRRQSKQRLSEENALVRSMAEQEWEKLQQAAHAQQQAYELASAADCDDSDVLYAAATDMMSPSGHTDAQTLAMMLQEQLDAINNEIRLIQEEKQSTEARAEELESRVGSLEHVNLLARGRSMDRQSPPMSGRSTPNSPQRDFMQKYHTLNLPVLSSDASREELHGGMSTTGDSSSGGAASPLTARSMRLERVAQALAHSQEELRRRSIGLNPNASVAPNHTGGHMPLSSHSYGLSPLSSRYGSQESLRHYNTMGSMSMLQTPTSGVSREAAAAAVQKKKGIKSSLGRFFSKKEKVKGVKDTLPDGSPSMMSIGNLSIGLSEVDSNYDAMSMTGGMMPRIASSQGSKISSVDYGRQKKEHDYRNDLLGEAMKAGTPFALWNGPTIVAWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPQTSRTTLAFGDMNHEWIGNYWLPGLGLPQYRTTFMECLVDARMLDHLTKKDLRGQLKMVDSFHRTSLQYGISMLKRLNYDRTELEHRRKMSENGLCDVLVWSNERVIRWVGSIGLKEYANNLLESGVHGGLMALDEGFDANAMGLALQIPTQNAQARQILDTEFNNLLQIATDRRPENEQRSAS
Protein: UBC core domain-containing protein (Q54F00)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- HECT-type E3 ubiquitin transferase
- Ubiquitin-like modifier-activating enzyme 1
Sequence:
MATTTNNTISFLPRIKQELNHFEKDPPPGIQAWLIENKLNSLEAMIIGPEETPYYKGLFKLEISLPSRYPFEPPQIKFLTPIYHPNIDTNGRICLDILKMPPSGEWKPSLNLLTILTSIRLLMSNPNPYDPLMQDISEIYKNNYNQFFKNAEHWTTKYATKNIEVEDDEKIYKKRIRGDEVSEEEPTAKSLKKLQNNTLNNNKNNNNNNNNNNNNNNNNNNNNNNNNNQNDKSNDNNNNDEKDQLGKRLSNQNNINIKISNSTLKKEEIKNDNINTTERDNDQSDDDDDSWS