wanglab/gogpt-training-data huggingface dataset:
Protein: TDP-daunosamine transferase DnrS (EC 2.4.1.-) (2,3,6-trideoxy-3-aminohexose transferase) (Q54824)
Organism: Streptomyces peucetius
Function: Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the addition of the TDP activated glycoside, L-daunosamine-TDP (2,3,6-trideoxy-3-aminohexose-TDP) at position C-7 of epsilon-rhodomycinone to yield rhodomycin D. Glycosylation is a prerequisite for biological activity of anthracyclines and requires DnrQ which seems to act as an activator.
Interaction partners:
Sequence:
MKVLVTAFAMDAHFNGVVPLAWALRAAGHDVRVASQPALTDSITRAGLTAVPVGTDHQVQAAMGAMAPGVFALHLNPDYLENRPELLDLEFLEASTSMLTAAFYAQINNDSMIDEMVDFAAWWRPDLVVWEPFTFGGAVAAQVTGAAQARLLWGPDLFLRVHDRFQQVLHEVPAERRDDALEEWLTWTLERHGAAFGPEVISGHWTIDQMPPSVRFATARPTVPMRFVPYNGPVPAVVPPWLRADPGRPRVLLTQGITERSTGFTGLPRAGELLASIAELDAEVVATVKAEEREGLPPLPGNVRVVDSLSLHVVLPSCAAVVHHGGAGTWATAALHGVPQLALAWQWDDVFRAGQLEKLGAGIFLPPHGEGASAGRVRDRLAQVLAEPSFRQGAARIRAEMLRTPAPGAVVPTLEQLTARHRAPAGQGVRH
Protein: Probable methyltransferase PMT11 (EC 2.1.1.-) (O22285)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein.
Interaction partners:
- DNA polymerase delta subunit 3
- Outer arm dynein light chain 1 protein
- GDSL esterase/lipase At1g28590
- Histone H4
Sequence:
MKPLTNGDLFKSPTLIKISALVFVTVAFFYLGKHWSDDGYQQLVFFSSSTSGSSIPEVSVSPNSNRVFNLSAIIPTNHTQIEIPATIRQQPPSVVADTEKVKVEANPPPPPPPSPSPPPPPGPVKSFGIVDANGVMSDDFEVGEVESDTVEDWGNQTEIVEAKSDGDSKARVRIKKFGMCPESMREYIPCLDNTDVIKKLKSTERGERFERHCPEKGKGLNCLVPPPKGYRQPIPWPKSRDEVWFSNVPHTRLVEDKGGQNWISRDKNKFKFPGGGTQFIHGADQYLDQMSKMVSDITFGKHIRVAMDVGCGVASFGAYLLSRDVMTMSVAPKDVHENQIQFALERGVPAMAAAFATRRLLYPSQAFDLIHCSRCRINWTRDDGILLLEINRMLRAGGYFAWAAQPVYKHEPALEEQWTEMLNLTISLCWKLVKKEGYVAIWQKPFNNDCYLSREAGTKPPLCDESDDPDNVWYTNLKPCISRIPEKGYGGNVPLWPARLHTPPDRLQTIKFDSYIARKELFKAESKYWNEIIGGYVRALKWKKMKLRNVLDMRAGFGGFAAALNDHKLDCWVLSVVPVSGPNTLPVIYDRGLLGVMHDWCEPFDTYPRTYDFLHASGLFSIERKRCEMSTILLEMDRILRPGGRAYIRDSIDVMDEIQEITKAMGWHTSLRDTSEGPHASYRILTCEKRLLRA
Protein: [histone H3]-trimethyl-L-lysine(9) demethylase (EC 1.14.11.66) (A0A8I6A8Y8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEVVEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKPMTVKEFRQLANSSKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRNDMVKISMDIFVKKFQPDRYQIWKQGKDIYTIDHTKPTPESTPEVKTWLQRRKKLRKAPKSLQGNKSLSKRPKAEEDEEFAEFIGEEVSSPAVCPRHLKVTEKPEKFKLANIGASSEKEASDTRIQVDQSLTNDTKLSGKESRLLKILQLESPKIPSSLAESNRVLTEGEENDEEGHASNLEPGEVPDALSEERNGLNVPKIIEGQPKTTKSWRHPLGKPPARSPMTLVKQQVASDEELPEVLSIDEEVEETESWAKPLIHLWQTKSPNFMAEQEYNATVAKMEPNCAICTLLMPYYKPDNSKEENDSRWETAVNEVVQSGRKTKPIIPEMCFIYSEENVEYSPPNAFLEEDGTSLLISCSKCFVRVHASCYGVPSHEVCDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNQWAHVICAVAVPEVRFTNVPERTQIDVDRIPLQRLKLKCIFCRQRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHRVNSNVKSKTCEKAISVGQTVITKHRNTRYYSCRVIDVTSQIFYEVMFDDGSFSRDTFPEDIVSRNCVKLGPPAEGEVIQVKWPDGKLYGAKYLGSNVAYMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADVIQGERKRQRVLSSRLKNEYVDDPVYRTFLKSSFQKKCQKRQ
Protein: RNA-binding protein NOB1 (EC 3.1.-.-) (Phosphorylation regulatory protein HP-10) (Protein ART-4) (Q9ULX3)
Organism: Homo sapiens (Human)
Function: May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16172919}.
Interaction partners:
- Pre-rRNA-processing protein TSR1 homolog
- Protein LTV1 homolog
- Serine/threonine-protein kinase RIO2
- RNA-binding protein PNO1
- Bystin
- Serine/threonine-protein kinase RIO1
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein eS17
Sequence:
MAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPQKVKVSSSIQHPETPLHISGFHLPYKPKPPQETEKGHSACEPENLEFSSFMFWRNPLPNIDHELQELLIDRGEDVPSEEEEEEENGFEDRKDDSDDDGGGWITPSNIKQIQQELEQCDVPEDVRVGCLTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSQKARQKTNVFAPDYIAGVSPFVENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR
Protein: F17A17.37 protein (Q9SFB1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell envelope {ECO:0000256|ARBA:ARBA00004196}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Classical AGP protein
- At2g10940/F15K19.1
- Uncharacterized protein At5g39570
- Vacuolar protein sorting-associated protein 29
Sequence:
MAVPKAIILPILLLICGAALGAPASEGYLRNGNFEESPKKTDMKKTVLLGKNALPEWETTGFVEYIAGGPQPGGMYFPVAHGVHAVRLGNEATISQKLEVKPGSLYALTFGASRTCAQDEVLRVSVPSQSGDLPLQTLYNSFGGDVYAWAFVAKTSQVTVTFHNPGVQEDPACGPLLDAVAIKELVHPIYTRGNLVKNGGFEEGPHRLVNSTQGVLLPPKQEDLTSPLPGWIIESLKAVKFIDSKYFNVPFGHAAIELVAGKESAIAQVIRTSPGQTYTLSFVVGDAKNDCHGSMMVEAFAARDTLKVPHTSVGGGHVKTASFKFKAVEARTRITFFSGFYHTKKTDTVSLCGPVIDEIVVSHVA
Protein: Emerin homolog 1 (Ce-emerin) (O01971)
Organism: Caenorhabditis elegans
Function: Nuclear lamina-associated inner nuclear membrane protein that is involved in cell division, nuclear structure organization, maintenance of nuclear envelope integrity and nuclear envelope reformation after mitosis. Involved in chromosome segregation and cell division, probably via its interaction with the nuclear intermediate filament protein lmn-1, the main component of nuclear lamina. Required to organize the distribution of lmn-1, nuclear pore complexes (NPCs) and chromatin in mitotically active cells. Together with lem-2, plays a role in baf-1 enrichment at the nuclear envelope in anaphase. Together with lem-2, involved in muscle cell attachment to hypodermal cells, as well as muscle cell location and sarcomere organization. May play a role in radiation-induced DNA damage repair response. May repress binding of transcription factor pha-4 with target sequences in pharyngeal cells.
Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:10982402, ECO:0000269|PubMed:11870211, ECO:0000269|PubMed:12490171}; Single-pass membrane protein {ECO:0000269|PubMed:10982402, ECO:0000269|PubMed:11870211, ECO:0000269|PubMed:12490171}; Nucleoplasmic side {ECO:0000269|PubMed:10982402, ECO:0000269|PubMed:11870211, ECO:0000269|PubMed:12490171}. Nucleus envelope {ECO:0000269|PubMed:16950114, ECO:0000269|PubMed:25653391}. Note=Lmn-1 and mel-28 are required for its localization to the nuclear envelope (PubMed:11870211, PubMed:16950114). Remains in the nuclear envelope until mid-late anaphase (PubMed:10982402). Recruited to the reforming nuclear envelope from telophase and throughout interphase (PubMed:25653391). {ECO:0000269|PubMed:10982402, ECO:0000269|PubMed:11870211, ECO:0000269|PubMed:16950114, ECO:0000269|PubMed:25653391}.
Interaction partners:
- Lamin-1
- Barrier-to-autointegration factor 1
- Ankyrin repeat and LEM domain-containing protein 1 homolog
- Nsp1_C domain-containing protein
- Sun domain-containing protein 1
- Nuclear migration and anchoring protein unc-84
Sequence:
MDVSQLTDAELRDSLKSHGVSVGPIVATTRKLYEKKLIKLSDGSINNQSNLNDSQFNEDSLIISSSPKKSPPQRVFQNVSAATAAATTSPESDSDDCEESMRYLTEEEMAADRASARQAQSNKGGFLGSTITFTILFVFIAVFAYFLIENAEQLKLVAETNPEDTI
Protein: Cilia- and flagella-associated protein 418 (Q581R2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Photoreceptor inner segment {ECO:0000256|ARBA:ARBA00004437}.
Interaction partners:
Sequence:
MSDVDDLIEELFPKKEGGRAPPEGKGGAACEPPASQSNWDDTDEANSEAETTTRNRGTSVSLEAAASTTANVGDGRGEDFDDSDESVEETVMGGRHTVPFPPTPGNMSMACNSKCFVTNVGSGELRHPSVAQLLLTGEGKYDKCSSNEQLLLRKGAFHALKADAGNGCTDKTADEDGRKGGCPFILCRKCNYTVIRLQDAEWDDEEGKMDLYLTVRNFYPDWSRLASSLPVGQMRRGEQNTVLKTCPDSAAYCCQCSWLTVKCAQEVIDTRVTDHTKFVGKELTCCFATQLPLISGEKRRPPLWVCGGHVPKH
Protein: Tafazzin family protein (F6Y2X3)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004137}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004137}; Intermembrane side {ECO:0000256|ARBA:ARBA00004137}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00024323}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00024323}; Intermembrane side {ECO:0000256|ARBA:ARBA00024323}.
Interaction partners:
Sequence:
MPLHVKWPFPAVPPLTWTLASSVVMGLVGTYSCFWTSEWAQAEAGPPGYPCPAGGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQKGMDFILEKLNHGDWVHIFPEGIGRLIAECHLNPIILPLWHVGEPGDGDREMASGVGGLGLPLVPGCPAPPHVWPSVHCAAGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQPGR
Protein: DnaJ homolog subfamily B member 8 (Q8NHS0)
Organism: Homo sapiens (Human)
Function: Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
Interaction partners:
- Heat shock 70 kDa protein 1A
- Heat shock 70 kDa protein 4
- Heat shock cognate 71 kDa protein
- Stress-70 protein, mitochondrial
- Heat shock 70 kDa protein 6
- Heat shock-related 70 kDa protein 2
- Heat shock 70 kDa protein 1-like
- Endoplasmic reticulum chaperone BiP
Sequence:
MANYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTPYHSPFDTGYTFRNPEDIFREFFGGLDPFSFEFWDSPFNSDRGGRGHGLRGAFSAGFGEFPAFMEAFSSFNMLGCSGGSHTTFSSTSFGGSSSGSSGFKSVMSSTEMINGHKVTTKRIVENGQERVEVEEDGQLKSVTVNGKEQLKWMDSK
Protein: FI03615p (Rapamycin-insensitive companion of Tor, isoform A) (Q9VWJ6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Serine/threonine-protein kinase mTor
- Protein LST8 homolog
- Stress-activated map kinase-interacting protein 1
- Raptor, isoform B
- RAC serine/threonine-protein kinase
- LOBE
- Ribosomal protein S6 kinase
- GTP-binding protein Rheb homolog
- Gigas, isoform A
- Serine/threonine-protein kinase Smg1
Sequence:
MASQHSSWRFGKRSKLQLRIKVSQDPEDFYRLDPQRSAAENAFEIYSMLCLEETRDTKRLFLLNALASLCLGARKGSHHSNIRFTTEELLYCLSASLVHTFTQVRAAALRTIRYAISTPNDIKTFNALQLQHLLCRSIDLMLKNDDERVQALKLVRKMLAIAPEDISPAVVRCLVSLADSGIEENDNLLRACLATLAEFAVLNPALLIVCGGVTSITRNVLECHNPRIAESLCGVLLYLLEWPQTRNICGVRLDCLAAPYCDFTYRQSIVDKNKDARELRYTSCRLALLSVLRSWTGTLEFCDPSKPSGLKAIVDALYLNQIEVRKAILDLLYELLTLPQPTWTDDYAVALQAVDPSDFQDTWLLSNGFVSAEGRSILPTLAARAPSVVEQHLALMLYCFLETGLLNALVEVVVSSDQFVSVQATVLIGKILQLMHTHLPPDICCTSPALPTLVSHATLGNQQANAAVAALQNYQKLLRQRPASRSLFLDSIIQGGALIQTRLFRRHLNVQEQAGPVLQLQETAEAAAFAVPPVTQFRGTLDRSRLDSVSSSDESNSQASTSSRSSFRLKRKFLPQALYDNFRAFNRLLTDSRVLSQADAHLWDWDVITTILKSNLIRKLDYTQGKFLKRLVDFYKPRNNRFSHQDLVPGQRLPTYVSAGLDLIDVLLSSNELECMRFITDYFSDISQQLAAVTTSNRAHDCLFSPQHMNNTMCQQYFLYIGRMCRTVKGIEVLKNTTVFEYLINLVRVTDHVCYVKLIVSGLNYSYEKLPRQVLEKALTSAKTRGRLYSTQFMAVLLRARLPHFEVWGIPLIINQTRDSDRSVGLAAMDVLEEACHDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLNSTMARIEDEIRYWRNGYNKRYVLLVEADTHSSLTLHIRNEDGYYSRRNCNQRPQTVPPNVAPHLYGQMAQTGQGMTALRKHGDLPQLLELLRRAKCTDDAECLELKAAIWALAHASTHSNGIEYFVELNARLYEKLIVLVTKCEVYSVRATCFSALGLIAGTQAGANILFKLNWLSVRHDKNTMWPVHQPEDWMSSQYTPVRHYYEDVPADNMTMMDDYIERFYETGSDFWHMLADQTDASGGGGGVAGTVVGMHPIVQDPNATITTTDSVRTTTDDVHPRMLVGVAAKSKTLPEGSNLRQGKHQRSLSESKTTDVISLLGSGVGTMSGAVLYPTPYQHRIRYNSCTDSNTSGVSSCESVTGRTAAAYAAAANELQQFPLSPIPSMSNLLESDELFRRNQLATSMLPSTLSPMAMKGYVQLRSLRKHSRPVFSESSAEFYDFAEILDTPEVQMRKLDWTHSHRRLKVRSLDRQLSDVYRRLSADELNVLLPTLNAPKFLPPNDLKGPCYAGICLPKNVLDLFPTRNLSRTYVSRDIQDQDIVGINLLNTMLRPQCLNDSLTNEGGDESSVISSLSDVSSASRRQTRQLQQGAKHSRSLCLHCARSPRQQRNDSGSHSNGGGGASLAPCELYSSAAAALVAAGIQAGPVLAKKSGSSAQGASAALGADISFHSPESMLSEDSLPDRLTASILYNVQRLANPVSAKQSKMALLELKQKHPHAFQDICLYSEACKTIGRSSYRMIARRFLQELFLDLNFDSFYVEPQLIIGARKFSAEEKAEATAPTAMQAMPFKQTILKPKPAAQLASVYETSWENLLMDQSPRINKSSPADQPANAQTKAKARNQLHIDDTESSLSSTDGENDSGEDVCDGSGAGTQASSVTTAHTALPTGNSNRSSIGTCTASQLVPGAATSNSAGAGTSASDNASTSLKNENRQFTRGRFYTLELDLSCTKNKFPIKNRSQRTPTPPPIESLIESKPTVQTDVNTSALPIMQRTGGSNDSSSALRYSTVTKSLSASMARPVGSLYCEKRLQSSKSEAVLDEVAKARRASGGVGLTTVRDNS
Protein: Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein) (Q9QUP5)
Organism: Mus musculus (Mouse)
Function: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Aggrecan core protein
- Versican core protein
- Hyaluronan synthase 3
- Hyaluronan synthase 2
Sequence:
MRSLLLLVLISVCWADHHLSDSYTPPDQDRVIHIQAENGPRLLVEAEQAKVFSHRGGNVTLPCKFYRDPTAFGSGIHKIRIKWTKLTSDYLREVDVFVSMGYHKKTYGGYQGRVFLKGGSDNDASLVITDLTLEDYGRYKCEVIEGLEDDTAVVALELQGVVFPYFPRLGRYNLNFHEARQACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGFWDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKLLGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN
Protein: Ankyrin repeat and SOCS box protein 14 (ASB-14) (A6NK59)
Organism: Homo sapiens (Human)
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Interaction partners:
Sequence:
MDNYTSDEDIDEDFDTQLIIQQSLQDIYKPGTAQHAPKDESLHSFLSADYKKIVETIEKVGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILEITLSASDPSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGKIFCLASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTGTW
Protein: Kinase (EC 2.7.-.-) (Q95R55)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTMTSTVLQRPIQAKPEKKASSKSTSSSRSRSTMAWSNEKLRFSCIDNIGLKQLWKLIALDTSASSKQRSAMMLEVEQQQQQQQQQQSNNNNERIPNENCDYLSLQRSGQAPKNHIQSHDPAQMSLLKFLAINALELSAPATPHLLQHQQAHKQAKPQGWMQLSGHPESIVPTSTGIVRKRISGLEDSEVHAYRLICKEPQTAQIVPAYFGIQEMQSQHFIELQDLLAGFRDPCVMDIKMGSRTFLESEVSNATLRPDLYQKMIAVDAGAPTPAEHEARAITKLRYMTFRESLSSSHSKGFRIEALRLRGRPPVKDLKTCRSSEQIAQTIEQFLAARRSVQKELLKRLKHMRLVIEQSTFFASHEIIGSSIFIVYDDDRVGVWLIDFAKCRELPPHVRVDHRSAWAPGNREEGLLRGMDELIRSFEEVYARCGSHRSCLKI
Protein: Protein FAM32A (G5ECC8)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MKDTVVKGSLKLKKVSTEAPKKTKKSKPAMDLKQVDMTIRRNTSGGGPHKTEAELRFEARRQANMAERMLKQAALSHREKVEKLNKQLGEMTEFNDIPKVSWTK
Protein: HTH-type transcriptional repressor KstR2 (P9WMB9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Controls the expression of a small regulon that may play a role in the utilization of cholesterol.
Interaction partners:
- HTH-type transcriptional repressor KstR
- Steroid 3-ketoacyl-CoA thiolase FadA6
- (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA hydrolase (HIEC-CoA hydrolase)
- Acyl-CoA dehydrogenase IpdE1
- 3-ketosteroid-9-alpha-monooxygenase, oxygenase component
- Probable short-chain type dehydrogenase/reductase
- Probable transcriptional regulatory protein
- HTH-type transcriptional regulator EthR
- Flavin-dependent monooxygenase, oxygenase subunit HsaA-triene-9,17-dione 4-hydroxylase, oxygenase subunit)-triene-9,17-dione monooxygenase)
- Probable transcriptional regulatory protein
Sequence:
MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTANPLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTWVSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV
Protein: Mothers against decapentaplegic homolog 1 (SMAD family member 1) (Q9I9L8)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
RLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQSSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPHNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPASSDPGSPFQMPADTPPPAYLPPEDQMTHDTSQPMDTNMMAPGIHPDIHRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSILVDGFTDPSNNK
Protein: Signal peptidase complex subunit 1 (Microsomal signal peptidase subunit 1) (P46965)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8663399}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Signal peptidase complex catalytic subunit SEC11
- Signal peptidase complex subunit 3
- Signal peptidase complex subunit 2
- Translocation protein SEC62
- ER-derived vesicles protein ERV46
- ER-derived vesicles protein ERV41
- Kinetochore protein SPC25
- Protein transport protein SBH2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2
- Protein transport protein SBH1
Sequence:
MSEILQDVQRKLVFPIDFPSQRKTEKFQQLSLMIGALVACILGFAQQSLKVLLTAYGISCVITLICVLPAYPWYNKQKLRWAQPKIEINVDQYD
Protein: Beadex, isoform D (M9PI02)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Chip, isoform B
- Helix loop helix protein 3B
- Fringe glycosyltransferase
- GATA-binding factor A
- Protein apterous
- Protein daughterless
- Achaete-scute complex protein T5
- Sequence-specific single-stranded DNA-binding protein, isoform D
- Achaete-scute complex protein T4
Sequence:
MMTMDITKTEPGLVGLSSNQQQQQQQQSQQSNAGMNSGGQNNGPNPNGNGNVVNVVNSGGAGGGNNGNGNVQSIAAAANNNNNNNNNGSQLCAGCGKHIQDRYLLRALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGNLMLCKRDYLRLFGNTGYCAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCENKILCEYDYEERLVFASMANHPMLKRHVSSLGQGSPTGAAGAQNTAGGLLGGGPGGGNVNGVGMVNGPRTPGDHNNNNNGPQTPTGGGSPFAAAAAAAAAAAHMKNQLGASSXNKALGMGAAGAVVPGSGVGAGVGVGVGAASQQFYSGFGLQHQHQHQQHHQQQQQQQQLMGLGLGMGGGGGVGGGGAGSAGGPGGGAGGGGGVGSIGSGCKRYQRKFYNRN
Protein: C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Interferon-inducible protein 10) (Protein Mob-1) (Small-inducible cytokine B10) (P48973)
Organism: Rattus norvegicus (Rat)
Function: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P02778}.
Interaction partners:
- C-X-C chemokine receptor type 3
- C-X-C motif chemokine
- C-C chemokine receptor type 5
- C-C motif chemokine 5
- C-X-C motif chemokine
- Platelet factor 4
- C-X-C motif chemokine ligand 13
- Chemokine
- Stromal cell-derived factor 1
- C-X-C chemokine receptor type 4
Sequence:
MNPSAAVVLCLVLLSLSGTQGIPLARTVRCTCIDFHEQPLRPRAIGKLEIIPASLSCPHVEIIATMKKNNEKRCLNPESEAIKSLLKAVSQRRSKRAP
Protein: Protein TASOR (Transgene activation suppressor protein) (Q69ZR9)
Organism: Mus musculus (Mouse)
Function: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (By similarity). Plays a crucial role in early embryonic development. Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division. Plays an important role in maintaining epiblast fitness or potency.
Subcellular location: Nucleus {ECO:0000269|PubMed:24781204}. Chromosome {ECO:0000250|UniProtKB:Q9UK61}. Note=Localizes to chromatin. {ECO:0000250|UniProtKB:Q9UK61}.
Interaction partners:
- M-phase phosphoprotein 8
- Periphilin-1
- Histone-lysine N-methyltransferase SETDB1
- Uncharacterized protein
Sequence:
MATAAETEAPSTDASWKSRGGGGGDDGMKPALPELESSLQNGGGDGGGGAGPEETAAAEAARSYGHEQPQQTSEAAAAALPKGAEEPERPFRRSFQIPRKSREKKALFQPLTPGSREFEDVLNILHSSYLEPSSVTYFNYRRACLIHNELLEKEFTEKRRELKFDGRLDKELSESYAFLMVDRYQVQSICEKGLQVGQSKITVLGSPSMGIYLCRYADLLQANPLEAGAVGDVVIFKIMKGKIKSIYDPLSVKSLESMLSKNALDPTPKHECHVSKNASRITSLLAYRAYELTQYYFYEYGFDEVRRRPRHVCPYAVVSFTYKDDVQTPKFLSPLRSNSFNADRNIDKFNYTLWKGQLLNKGKLLCYISLRSANRAFLPVKLPEKLDVETVMSIDCLKQKIPPSFFYKDTYVGPNEVLKNGMYCSLYEVVEKTRIGSNMECLLQKLEKEKLVLVKPLGDRGYLFLLSPFQMVSPYEHQTVKSRILHALFLFQEPRCLIITQKGIMNTTPLEKPENLADILKITQFLQFSLIQCRKEFKTINTINFHSVVEKYVSEFFKRGFGSGKREFFMFSYDSRLDDRKFLYSAPRNKSHIDDCLHTYIYQPEMYQLSIFKLKELFEENWRRQQFSPLSDYEGQEEELNGSKMKFGKRNNSRDETTEPEQQKSSHSLDYDKDRVKELINLIQCTKKNVGGDPDPEDTKSKNVLKRKLEDLPENMRKFAKTSNSTESCHLYEESPQSIGLLGQDPNLRVQQEDSGNTGDIHKLYNWLSEALANARHSDGFLTETVNKALGLSSSGAYEELKQKCDYELNSTLDKKESEQPACTKIENVHFKDAQSPLLEVDAASVKYPPLLSSSEVGINHKLHCKEDPNLINVNNFEGCSLCPTVSIEHGFLRQHSKSNDDEETEIHWKLIPITGGNAGSPEDQHGKHGEKQTPDTLKGTTEEDTVTAGQAMAVEEQCVPAAELPRVSEITENTVLGEFHLFSRKVEEILKEKNVSYVSAISTPIFSAQEKMNRLSEFIHSNTSKAGVEEFVDGLHEKLNTVVITASAKGVSLPPAVSANHSHAAAALASLGRRVVSISSSDFSAKELFEPLCSEHLKDNNSNEQYSSSVEVEMNRPHHCKELMLTSDHTVPGDTVLEPTEKEITKSPSDITISAQPALSNFISQLEPEVFNSLVKIMKDVQKNTVKFYIHEEEESVLCKEIKEYLTKLGNTECHPDQFLERRSNLDKLLIIIQNEDIAGFIHKVPGLVTLKKLPCVSFAGVDSLDDVKNHTYNELFVSGGFIVSDESILNLEVVTIESLKIFLTFLEELSTPEGKWQWKIHCKFQKKLKELGRMNTKALSLLTLLNVYQKKHLVEILSYHSCDSQTRNAPEMDCLIRLQAQNIQQRHIVFLTEKNIKMVSSYTDNGIVVATTEDFMQNFTSLVGYHNSVTEESLPPLLGANENLESQSALLENDEKDEEDMSLDSGDEISHIEVFSNVHSEILAGETKGSSGTDQKKNIQIELQSSLDVQNSLLEDKTYLIDCEASAPIDRVCSEGESSNSAEQDAYSDFQADQNQLQMSHQCSHFNVLTHQTFLGTPYALSSTRSQENENYFLSAYKNSGTEKSPLS
Protein: E3 ubiquitin-protein ligase Zswim2 (EC 2.3.2.27) (MEKK1-related protein X) (MEX) (RING-type E3 ubiquitin transferase Zswim2) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2) (Q9D9X6)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.
Interaction partners:
Sequence:
MLRGGCKASEKRRHLSESLSWQQDQALSSSIYLLRQIGPTGFLLKEEEPEKGDFRVLLGNPHECSCPTFLKRGELCKHICWVLLKKFKLPRNHESAFQLGLTEGEINDLLRGIHQVQAPQLRASDETAQVEEDGYLKQKDINAGDICPICQEVLLEKKLPVTFCRFGCGNNVHIKCMRILANYQDTGSDSSVLRCPLCREEFAPLKVILEEFKNSNKLITISEKERLDKHLGIPCNNCNQLPIEGRCYKCTECVEYHLCQECFDSCCHSSHAFASREKRNQRWRSVEKRSEVMKYLNTENEGEAKPGCFQEKQGQFYTPKHVVKSLPLLMITKKSKLLAPGYQCRLCLKSFSFGQYTRLLPCTHKFHRKCIDNWLLHKCNSCPIDRQVIYNPLIWKGIATDGQAHQLASSKDIACLSKQQEPKLFIPGTGLVLKGKRMGVLPSIPQYNSKVLTTLQNPSDNYQNITMDDLCSVKLDNSNSRKLVFGYKISKQFPTYLKNPTTGQTPSQTFLPSLPHKNIICLTGRESPHIYEKDHIGQSQKTSRGYEHINYNTRKSLGSRLRQHKRSSALSSEDLNLTINLGTTKLSLSKRQNNSMGKVRQKLGHPPRRPAYPPLQTQNAALSLIMQGIQL