wanglab/gogpt-training-data huggingface dataset:
Protein: Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7) (P08729)
Organism: Homo sapiens (Human)
Function: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:2459129}.
Interaction partners:
- Protein LIAT1
- Homeobox protein CDX-2
- Cell adhesion molecule CEACAM5
- Napsin-A
- Paired box protein Pax-8
- Homeobox protein Nkx-2.1
- Prolactin-inducible protein
- Synaptophysin
- Wilms tumor protein
- Alpha-methylacyl-CoA racemase
Sequence:
MSIHFSSPVFTSRSAAFSGRGAQVRLSSARPGGLGSSSLYGLGASRPRVAVRSAYGGPVGAGIREVTINQSLLAPLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVGAVNISVMNSTGGSSSGGGIGLTLGGTMGSNALSFSSSAGPGLLKAYSIRTASASRRSARD
Protein: Metal-dependent protein hydrolase (Q9SG17)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Urease accessory protein G
Sequence:
MFGSRGLCCSRIWNRSLFLKRSSNFRASFSTKRVGTHNGTFHCDEALACFILRRSNRFSDAQIVRTRDHQVLEKLDAALDVGGVYDPQSERYDHHQKGFSEVFGLGFNTKLSSAGLVYKHYGLEIISKELQLEQRHPDVFRLFLAVYKNFIEAVDALDNGIHQYDTDQPPRYVNNTSLGHRIGRLNLDWIEPDQSSAKEDEAFHRAMELAGSEFLECVHFHAKSWLPARSIVMECLAKRYDIDSSGEIMKLSKQCPWKLHIFELEEEMKIDPPIKYVLYQDDRSENWRIQAVSVSPERFESRKALPLAWRGLEKEKLSEESSIPRCVFVHMSGFIGANQTYEGALAMARASLMA
Protein: Neck appendage protein (Q9FZW3)
Organism: Bacillus phage GA-1 (Bacteriophage GA-1)
Subcellular location: Virion {ECO:0000256|ARBA:ARBA00004328}.
Interaction partners:
Sequence:
MHRPPFNKLRTIDNLSAYKYHIDYLPTAMDESLTLLQKVNMLIYNVNQTNAITNDLAERWNEIIEWLNTEAISKEVEKILEKWLSDGTLADIITDAVLGDIEKIKLALAEFEQLKKDFDKLRYDVDSITQTSGNAIYQKLIMRPFFGTETEQIFSGAENAPQGMAYVEFKGKKYIFILSRVEGTTWTKAERHRITQFELTEDGSLTQPLTFTKPLELGHQGLSAMVDNDKIWLFAGYGYGDFENNGKGYTKIEWKGSNTDECDIYRYRLLGAHGSNERYNEYNHATPTISTDGRFIVLAVATTFEANTRYMLIFDRKQVERAENPMSVPALNIFQIYAAPYVGSHIVQDVACDGNYVYIYTSDVAPLGVKIITIMSMQGFVVGYYKVDGGLALYDSLTGDPRYGDAVQMEAEGLTIMGSDLLLLSTDVWQKDGQYTKRDKLVYKVYRGCATCEGEPINQGIQPLTSPASVHIRGTVHDVSFPYGDGFTVSQWDEQNNEIYPSLSYNGQSIFRIYDTRPDSNNELPMTLRNNKAPSGGWVEIRSGSTLEDGAGINMYNVTNSALGGRMRLYVTDPVTLESVYFQIYQNGAIVPSTDNLQNMGQXSNRMRNIYAGTGAINTSDERHKTDIAPISDKVLDAWEKVKFYQYKFKDAVDEKGEEARYHFGVIAQQIVKVFEDEGLSAFDYGLVGYDEWEATEDEYDSEGNLVEKGREAGNIYSIRPTECQWLEMACMRRKLERLS
Protein: Protein NDH-DEPENDENT CYCLIC ELECTRON FLOW 5 (Q9C503)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain. May function in assembly or stabilization of the NDH complex.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:19122188}.
Interaction partners:
- Photosynthetic NDH subunit of subcomplex B 5, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 4, chloroplastic
- Photosynthetic NDH subunit of subcomplex B 1, chloroplastic
- Photosynthetic NDH subunit of lumenal location 4, chloroplastic
- Dihydrodipicolinate reductase-like protein CRR1, chloroplastic
- Protein CHLORORESPIRATORY REDUCTION 7
- NAD
- NAD
- Photosynthetic NDH subunit of lumenal location 3, chloroplastic
- NAD
Sequence:
MALVHYMNVSRSTFPLSRSSKINLSSSFASLPLQFHKNIKRLESSVPPSASASASPAFPIDVEYLRREFSGHGATFEDIGETCIARLKLDNGSSANVMLTRGMITSYKVRVWHGGKVELLHTWVEQEEEEVVIRGGVSSAFRSSDSDEISDWRLQGISGDSKDCVQMELRRSDKKIKEIELKQIISLRENTLSIELSMTNKGISPIKLEGCSLVSYLTVSTPEATYAVGLEGSDFVETTPFLPRFGVVQGEKEEEKPGFGGEEESNYKQLNREMSRIYTCAPKSFTVIDRGRRNSVVVGREGFEEVYMYSPGSRLESYTKSAYVCIGPSSLLSPISLESGCVWRGVLHLHNPNS
Protein: Uncharacterized 91 kDa protein in cob intron (P05511)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Probable intron-encoded endonuclease Cox1-I1b
- Uncharacterized cox1 intron-2 37.2 kDa protein
- ATP synthase subunit 9, mitochondrial
- ATP synthase protein 8
- Cytochrome c oxidase subunit 3
- Cytochrome c oxidase subunit 2
- Small ribosomal subunit protein uS3m
- Mitochondrial transcription factor 1
- ATP synthase subunit a
- DNA-directed RNA polymerase, mitochondrial
Sequence:
MRRCGIYVYPHRERDILCVKIWTIHLGSWGNPMPNRACVQKVLPVTKQISSDGSVQIDTVRAVLPEFQFPSHPQIGDCLSWIETFFSRSLVGFYDQGYTPGEESCTNSTIKGMSGKPTSIISNIYTTTGPAKVSNDYAVRDPGVAVDHFDQYGPLKEGRSLNSAKISTQWSGSATLKSSNRSIFNIGLGYINTFLGVSNVRGFSTGSGRSKNVLNKLDDLSKRSKNYPNLVIDRNLYKDFLLNRDMFLIAYNKLKSNPGMMTHGLKPDTLDGMSIDVIDKIIQSLKSEEFNFTPGRRILIDKASGGKRPLTIGSPRDKLVQEILRIVLEAIYEPLFNTASHGFRPGRSCHSALRSIFTNFKGCTWWIEGDIKACFDSIPHDKLIALLSSKIKDQRFIQLIRKALNAGYLTENRYKYDIVGTPQGSIVSPILANIYLHQLDEFIENLKSEFDYKGPIARKRTSESRHLHYLMAKAKRENADSKTIRKIAIEMRNVPNKIHGIQSNKLMYVRYADDWIVAVNGSYTQTKEILAKITCFCSSIGLTVSPTKTKITNSYTDKILFLGTNISHSKNVTFSRHFGILQRNSGFILLSAPMDRIAKKLRETGLMLNHKGRSVIRWLPLDVRQIIGLANSIIRGYDNYYSFVHNRGRFATYVYFIIKDCVLRTLAHKLSLGTRMKVIKKFGPDLSIYDYNSRDENNKPKLITQLFKPSWKVNVWGFKSDKVKLNIRTLYASHLSMANLENLQCAACQSTYKVEMHHVRQMKNLKPIKGTLDYLMAKANRKQIPLCRSCHMKLHANKLTLNEDKKV
Protein: Cystinosin (P57757)
Organism: Mus musculus (Mouse)
Function: Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:12370309}; Multi-pass membrane protein {ECO:0000255}. Melanosome membrane {ECO:0000250|UniProtKB:O60931}; Multi-pass membrane protein {ECO:0000255}. Note=AP-3 complex is required for localization to the lysosome. {ECO:0000250|UniProtKB:O60931}.
Interaction partners:
- Lysosomal amino acid transporter 1 homolog
- Sedoheptulokinase
Sequence:
MRRNWLLILTLFLLMFIEKYESTVSLTAPPTVKLENGSSTNVDITLGHPLNSTLVITFEVTFRSKNLTIVELPDEVIVPRGEKNASFQVTSQNIGQVTVFLHGNHSNQTCPRIRFLVIHSRIVSIINQVIGWIYFMAWSVSFYPQVIQNWRRKSVIGLSFDFLALNLTGFVAYSVFNIGLLWVPYIQEEFLLKYPNGVNPVDSNDAFFSLHAVALTLIVILQCCLYERGNQRVSWPSIGFLVLAWLFVLVTMIVAAVGITTWLQFLFCFSYIKLIITLIKYFPQAYMNFYYKSTKGWSIGGVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFTIFFDVVFFIQHFYLYRKKPGYDQLN
Protein: Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (rOAZ) (Smad- and Olf-interacting zinc finger protein) (O08961)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor COE1
Sequence:
MSRRKQAKPRSVKVEEGEASDFSLAWDSSVAAAGGLEGESECDRKSSRALEDRNSVTSQEERNEDDEDVEDESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSYLKRHEQIHSDKLPFKCTFCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRRDHLKIHLKTHSSSKPFKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTLHPQLSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSTPDPVLGSVASMSSATPDSSASVERGSTPDSTLKPLRGQKKMRDDGQSWSKVVYSCPYCSKRDFTSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKSHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPNANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSTKLESPVIQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSPVSSDVEVSSPKRQRLSGSANSISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQCKEDFDSQESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAHKCIFCGETFSTEVELQCHITTHSKKYNCRFCSKAFHAVLLLEKHLREKHCVFDPAAENGTANGVPPTSTKKAEPADLQGMLLKNPEAPNSHEASEDDVDASEPMYGCDICGAAYTMEVLLQNHRLRDHNIRPGEDDGSRKKAEFIKGSHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGSSAASSPNGQGLQKLYKCALCLKEFRSKQDLVRLDVNGLPYGLCAGCMARSANGQVGGLAPPEPADRPCAGLRCPECNVKFESAEDLESHMQVDHRDLTPETSGPRKGAQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGINHECKLCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFAVHGQEDKIYDCSQCPQKFFFQTELQNHTMSQHAQ
Protein: Protein gooseberry (BSH9) (Protein gooseberry distal) (P09082)
Organism: Drosophila melanogaster (Fruit fly)
Function: Expressed in segmentally repeating pattern to define the polarity of embryonic segments.
Subcellular location: Nucleus.
Interaction partners:
- Kekkon 2
- Protein wingless
- Mitochondrial import inner membrane translocase subunit Tim22
Sequence:
MAVSALNMTPYFGGYPFQGQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNRFQETGSIRPGVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSSISRLLRGSSGSGTSHSIDGILGGGAGSVGSEDESEDDAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQVPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAAYGGSVASMSPASSTSGTSSAAHSPVQTQAQQPGTGSEFMTSTYGVGSSNATYPSAAYSMPQTPATSAEQLRSQFASAAASGSHHPSTWDSYNFAGSFFPPASAAGNHISGYHHQVDQKSSMMTTAPTYPYFGF
Protein: Electron transfer flavoprotein subunit beta, mitochondrial (Beta-ETF) (Q9LSW8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Involved in leucine catabolism and in phytol degradation.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:14671022}.
Interaction partners:
- Electron transfer flavoprotein subunit alpha, mitochondrial
- Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
- At1g50450/F11F12_20
- Isovaleryl-CoA dehydrogenase, mitochondrial
- Geranylgeranyl diphosphate reductase, chloroplastic
- Peroxisomal acyl-coenzyme A oxidase 1
- Acyl-coenzyme A oxidase 4, peroxisomal
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Acyl-coenzyme A oxidase 2, peroxisomal
- Putative acyl-coenzyme A oxidase At3g06690
Sequence:
MKILVAVKRVVDYAVKIRVKPDKTGVETQNVKMSMNPFCEIALEEALRIKEAGFAKEVIAVSIGPSQCVDTLRTGLAMGADRGIHVETNSIFLPLTIAKILKSLADVENPGLIFLGKQAIDDDCNQTGQMVAALLGWPQATFASKVVLDKDKNVATVDREVDGGLETLNVDLPAVITTDLRLNQPRYASLPNIMKAKSKPIKKMTVQDLKVDIKSDIEILEVTEPPKRKSGVMVSSVDELIDKLKNEAHVV
Protein: Tetratricopeptide repeat domain 28 (F6QN66)
Organism: Macaca mulatta (Rhesus macaque)
Interaction partners:
- Serine/threonine-protein kinase Chk2
- Isoamyl acetate-hydrolyzing esterase 1 homolog
- RNA polymerase-associated protein LEO1
- Serine/threonine-protein kinase 40
- Coagulation factor XIII B chain
- Notchless protein homolog 1
- Heat shock protein 90 alpha family class B member 1
- Cystic fibrosis transmembrane conductance regulator
Sequence:
MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGANTFGQRSPDGPVLSKAEFVEKVRQSNQACHNGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVTLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGILKFNEHYLGENTVENSSDFQASSSATLPTATGSALEHHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSSLPRRQNSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQHPPFSPTGADSIASDAISVYSLSSIASSVSFVSRPEGGSEGGGPGGRQDNDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENQNMCFSPDHKQPRPGTAGGLRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSAAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSETSIKDSPSQNSGRPSPGSDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHEGTPPKAPPNGHWRTETTSLGALPLPAGPPAAAPARPLRLPSGNGYKFLSPGRFFPSSKC
Protein: Protein NipSnap homolog 1 (NipSnap1) (Q9BPW8)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:30982665}.
Interaction partners:
- Transient receptor potential cation channel subfamily V member 6
- THO complex subunit 5
- Sequestosome-1
- Transient receptor potential cation channel subfamily V member 5
- Next to BRCA1 gene 1 protein
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Gamma-aminobutyric acid receptor-associated protein
- Synaptosomal-associated protein 25
- GABA type A receptor associated protein like 1
- Tax1-binding protein 1
Sequence:
MAPRLCSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
Protein: Necdin (Q99608)
Organism: Homo sapiens (Human)
Function: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity).
Subcellular location: Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.
Interaction partners:
- Cellular tumor antigen p53
- Transcription factor E2F1
- Small nuclear ribonucleoprotein-associated protein N
- Tumor necrosis factor receptor superfamily member 16
- E3 ubiquitin-protein ligase makorin-3
- EP300-interacting inhibitor of differentiation 1
- Phospholipid-transporting ATPase VA
- NAD-dependent protein deacetylase sirtuin-1
- Ubiquitin-protein ligase E3A
- E3 ubiquitin-protein ligase Praja-1
Sequence:
MSEQSKDLSDPNFAAEAPNSEVHSSPGVSEGVPPSATLAEPQSPPLGPTAAPQAAPPPQAPNDEGDPKALQQAAEEGRAHQAPSAAQPGPAPPAPAQLVQKAHELMWYVLVKDQKKMIIWFPDMVKDVIGSYKKWCRSILRRTSLILARVFGLHLRLTSLHTMEFALVKALEPEELDRVALSNRMPMTGLLLMILSLIYVKGRGARESAVWNVLRILGLRPWKKHSTFGDVRKLITEEFVQMNYLKYQRVPYVEPPEYEFFWGSRASREITKMQIMEFLARVFKKDPQAWPSRYREALEEARALREANPTAHYPRSSVSED
Protein: Zygote defective protein 12 (Q23529)
Organism: Caenorhabditis elegans
Function: Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus. Required for dynein localization to the nuclear envelope. Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:14697201}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14697201}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14697201}. Note=Localizes to the minus end of microtubules, proximal to the centrosome. Centrosomal localization requires sun-1 and microtubules.
Interaction partners:
- Sun domain-containing protein 1
- Dynein light intermediate chain
- Nuclear migration and anchoring protein unc-84
- C2H2-type domain-containing protein
- C2H2-type domain-containing protein
- Nuclear migration protein unc-83
- UBC core domain-containing protein
- Serine/threonine-protein kinase plk-2
- Serine/threonine-protein kinase chk-2
- Nuclear anchorage protein 1
Sequence:
MLDLTNKESESSDNGNSKYEDSIDGREVGTSKPFKEERSLEDLQADLADMAVWMEGLDATKLPLNDPQLLCNGRAFSEVLHNVDKNFFTDGWLETMPENRTTNIMVFRSCTRKLWRKMFDYVNHINRTVVSSRWTDIHERIDGIYESDLPAMVNLGMAVVTLAHIGKNAKRFVDYSKALTSTHKSMMSNVAKMVTTVIDEMPENPCFHEISELHGSQSELNSLSESSGKLNGNGSSERRSNADQILVDAELEIERLRTETENQRKEIERLTKSFETAQHDMSSNSESGDISILEKQNEELRQKRRELEEKNLELDAAVDQFKGIVFELTNENDVLRRSDKERQRLQTVLDAAQSDLDEWKTVANQYQKEAELSKQQDKEIKELLSQNKALKSRLDHHVKSATLEDANKNGIAQLRTQVGGLTALNTELKASLDSKKRCVEQLEIQLIQHKEKVKELEDRKDELIEERNRLENQLIFKEAVTPRSLHESMFEAGNLSFEPFSEKNTLPLEIENKRLTERIQELESLEPLKGELITLKSKNGVLEEEKLFATKQIEELQQQIEDLQENLLKNQEHASGDVVGLKIQLEKAEVEAQQMREAKMRAETNQAQVDEILKKRTAELEVNATALQKAKAVIDELEYNSRPVSEDSMTSVQAFKEMKEENEKLRQKVEKLEIELNTVTQGFEQENRLLTSASHQQVLNRSIDEVMSMRAHAGSEEPQTLLDTQKMSGALPWRSLASETRRELPTAMASILVLGFLVFIAWMFININSALNAPPNA
Protein: Microfibrillar-associated protein 1 (Q93712)
Organism: Caenorhabditis elegans
Function: Involved in pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:22829783}.
Interaction partners:
- Putative zinc finger matrin-type protein snu-23
- Pre-mRNA-splicing factor 38
- SNU homolog
- U4/U6 small nuclear ribonucleoprotein Prp31
- Pre-mRNA-processing factor 6
- Splicing factor 3B subunit 1 domain-containing protein
- Pre-mRNA-splicing factor 8 homolog
- Smu-1 suppressor of mec-8 and unc-52 protein
- Pre-RNA processing 21
- Probable small nuclear ribonucleoprotein Sm D2
Sequence:
MGDYVPGFEQRESDNRSFGHSRLPTLGAIPIKNEKGQTVMQKVKVSRYVAGKAPEYARNYDSDSSESDRETDRDDDRRRRRRRESSDEEDRRRHRRHEDYGRRRQVEKPEVLGKVEDESSENEQESEEDEEKQEERRERARMRRLELHENNREKDEEQEDSAESDEEDFERRRQMLRDRAIKREEEIKREIKEELEEDDVEEEEEEESSEEEDSDEDDDPVPRLKPIFTRKKDRITLQEAEKEKEKEILKKIEDEKRAEERKRESAKLVEKVLQEEEAAEKRKTEDRVDLSSVLTDDETENMAYEAWKLREMKRLKRNRDEREEAAREKAELDKIHAMSEEERLKYLRLNPKVITNKQDKGKYKFLQKYFHRGAFFLDEEDEVLKRNFAEATNDDQFDKTILPKVMQVKNFGKASRTKYTHLTEEDTTDHQGVWASTNQLNSQFSTKRAGGSRPVFERPATKKRKN
Protein: Putative cytochrome P450 135B1 (EC 1.14.-.-) (P9WPM9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Polyketide synthase Pks13
- Peptide synthetase MbtE
- Possible oxygenase
- Vitamin B12-dependent ribonucleoside-diphosphate reductase
- Possible electron transfer protein FdxB
- Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1
- DNA polymerase I
Sequence:
MSGTSSMGLPPGPRLSGSVQAVLMLRHGLRFLTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEANSMLAGLLGDSSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEIAAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPRLLNVGPWATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPDLAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWALERLTRHPVTLAKAVQAADASAAGDPAGDEYLDAVAKETLRIRPVVYDVGRVLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRMVGATLSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVELSTTTTSGERPKLKHVIMVPHRGARIRVRATRDVSATSQATAQGAGCPAARGGGPSRAVGSQ
Protein: Isopeptidase-T-3, isoform C (A0A0B4KFW5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- RING-type E3 ubiquitin transferase
Sequence:
MIPWMREKFNEKRAKWLARSKRSGGSPADESPRSSSHSHSQRTDASDAESLSGSSLNVHTAESETQTDGGISASNSRPLVGGGSCVLRTPSPARRRRIHLELQLQRREERAEHQKVVPQDSPTPTHQQQANALFLRKSAHTNRPGSSTSGEADDASRPGESILVRVICPSSRVLIFKTDVNKRLNELKSEVILELSDDPDSIQLFAPDVRHLNPRYRLYRAEYFGGELNEGDTLAQLKVRNNETFILSPRRNTLPQTVSRIREVPGPNEQLVESATRYVPVNCNQLPTIDINEIFQQSNIQYDVRKVLISLAQASAAVIGAGPYAPRLIAMLKQRLINRRNQQADTLQCLVDMGFKRELAAFALKAHNGIYSTTMEWLIQNQNEENPQEPPGMNMQHSLSSISPSTIVTNNETIENTAALIEIVRIYSHRDSPPSDEIVESLTEMGFEETAVLAALKKTGNNKASACEWLCDNRSGSVIELREGLAPDSPILKVILEMPQVQMTLSNPKTFLAFLGILENEHAIRVWRGDNDTTSVITHILQKYHEEKHVLGINQFYTNRW
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (B1AMW7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREY
Protein: Flagellar export protein (FliH) (O25120)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Interaction partners:
- Flagellum-specific ATP synthase
- Flagellar motor switch protein FliN
- Flagellar motor switch protein FliG
- Flagellar M-ring protein
- Flagellar motor switch protein FliN
- Flagellar biosynthesis protein FlhA
- Basal-body rod modification protein FlgD
- Flagellar hook-associated protein 2
- Flagellar hook-associated protein 1
- Flagellar biosynthesis protein FlhF
Sequence:
MSLNSRKNLIQKDHLNKHDIQKYEFKNMANLPPKTNPNSASLETPNLEEPLEKKAIENDLIDCLLKKTDELSSHLVKLQMQFEKAQEESKVLIENAKNDGYKIGFKEGEEKMRNELTHSVNEEKNQLLHAITTLDEKMKKSEDHLMALEKELSAIAIDIAKEVILKEVEDNSQKVALALAEELLKNVLDATDIHLKVNPLDYPYLNERLQNASKIKLESNEAISKGGVMITSSNGSLDGNLMERFKTLKESVLENFKV
Protein: Eukaryotic translation initiation factor eIF1 (Protein translation factor SUI1 homolog) (Q9VZS3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably involved in translation.
Interaction partners:
- Eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 4C
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 2 subunit 3
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit J
- Small ribosomal subunit protein uS3
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 2 subunit 1
Sequence:
MSIQNLNTRDPFADAIKGNDDDIQDGLVHIRIQQRNGRKTLTTVQGLSAEYDLKKIVRSCKKEFACNGTVIEHPEYGEVLQLQGDQRENICQWLTKVGLAKPDQLKVHGF
Protein: Olfactory receptor (Q8VFH0)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
MWLQVMEKENTSSFEGFILVGFSDRPHLELILFVVVLSFYLLTLLGNMTIILLSALDSRLHTPMYFFLANLSFLDMCFTTGSIPQMLYNLWGPDKTISYVGCAIQLYFVLALGGVECVLLAVMAYDRYAAVCKPLHYTVIMHPRLCGQLASVAWLSGFGNSLIMAPQTLMLPRCGHRRVDHFLCEMPALIGMACVDTMALEALAFALAIFIILAPLILILISYGYIARAVFRIKSAAGRRKAFNTCSSHLIVVSLFYGTIIYMYLQPANTYSQDQGKFLTLFYTIVTPSVNPLIYTLRNKDVKEAVKKVLGKGSIEV
Protein: SP100 nuclear antigen (E9PHV6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGGGGDLSTRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPLESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGKED