wanglab/gogpt-training-data huggingface dataset:
Protein: Delta(6)-fatty-acid desaturase fat-3 (FAT-3) (EC 1.14.19.3) (Delta(6)-fatty-acid desaturase) (Ceeld6) (Fatty acid desaturase 3) (Q23221)
Organism: Caenorhabditis elegans
Function: Can function as a Delta(6) fatty acid desaturase. Introduces a double bond in the fatty acid chain 6 carbons away from carboxy terminal to biosynthesize polyunsaturated fatty acids (PUFAs) endogenously (PUFAs are essential for membrane structure and many cellular and physiological processes). Acts on a variety of substrates such as linoleoyl-CoA ((9Z,12Z)-octadecadienoyl-CoA, C18:2n-6) and alpha-linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA, C18:3n-3) to produce gamma-linolenoyl-CoA ((6Z,9Z,12Z)-octadecatrienoyl-CoA, C18:3n-6) and (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA (18:4n-3) respectively. Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (By similarity). Plays a role in synaptic vesicle recycling by regulating synaptojanin unc-26 localization at synapses.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Delta
- Omega-3 fatty acid desaturase fat-1
- 2Fe-2S ferredoxin-type domain-containing protein
- Delta
- Long chain fatty acid elongase 2
- Long chain fatty acid elongase 1
- Delta
- Delta
- Fatty acid synthase
- Alkylglycerol monooxygenase
Sequence:
MVVDKNASGLRMKVDGKWLYLSEELVKKHPGGAVIEQYRNSDATHIFHAFHEGSSQAYKQLDLLKKHGEHDEFLEKQLEKRLDKVDINVSAYDVSVAQEKKMVESFEKLRQKLHDDGLMKANETYFLFKAISTLSIMAFAFYLQYLGWYITSACLLALAWQQFGWLTHEFCHQQPTKNRPLNDTISLFFGNFLQGFSRDWWKDKHNTHHAATNVIDHDGDIDLAPLFAFIPGDLCKYKASFEKAILKIVPYQHLYFTAMLPMLRFSWTGQSVQWVFKENQMEYKVYQRNAFWEQATIVGHWAWVFYQLFLLPTWPLRVAYFIISQMGGGLLIAHVVTFNHNSVDKYPANSRILNNFAALQILTTRNMTPSPFIDWLWGGLNYQIEHHLFPTMPRCNLNACMKYVKEWCKENNLPYLVDDYFDGYAMNLQQLKNMAEHIQAKAA
Protein: Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)] (Q99075)
Organism: Homo sapiens (Human)
Function: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Subcellular location: [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; SUBCELLULAR LOCATION: [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Receptor tyrosine-protein kinase erbB-4
- Epidermal growth factor receptor
- Pro-epidermal growth factor
- Receptor tyrosine-protein kinase erbB-3
- CD44 antigen
- CD9 antigen
- Glypican-1
- Disintegrin and metalloproteinase domain-containing protein 17
- Nardilysin
- Proepiregulin
Sequence:
MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH
Protein: Histamine-gated chloride channel subunit (A1KYB4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MVFQIIILVICTICMKHYAKGEFQQSLAITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHVTQECKLQMESLSHTTDDLIFQWDPTTPLVVDENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVFYEYL
Protein: Bem3p (A0A1D8PLJ2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Rga2p
- Cell division control protein 42 homolog
- Uncharacterized protein
- Rho family guanine nucleotide exchange factor
- Phosphatidylinositol-3-phosphate-binding protein
- Lrg1p
Sequence:
MMKSTTIMARSISQDSRHEYPNSDTKLERTHLSDAQYIEQLLFENKELKALVDRQKKIIEKLNNQLKSSNGNKLTLDLINNRTPPLSQKSSLDNPEPEPEPEPEPELQTSTATEVCFKRVSAALSPTLVTIPKSPQRSISNHSMQLSPTRQILSVQRQENMADATSSDPVTQDIPLRSSRRRRNSNESKSLDKKASYISLESSTTPLQIPNSMSNESTSSSSYQTNGNGRANEYASIKSPDFEVDLGNITSKSDTINNTFDSKMGMDTTIGTVDSIDSGKINETVESQFSTMESTKSQLDISGSSTATGTGTGSSTLGAAASSSSTGVSKIYSQSKGIARSSSSVGSTYKSSRIKPPNLQTKPSNSSTVDLAPPTSLKTAASNISSSVEQKSPSLQYDTSPQIQSDTNIKSQLAPPYEMSKSNNEQAPPVPPPKPNSKPTLNLSNQSSRSTGDSNQFATSYDGPATPRPTIQTPNTSSFNVNSAPQTPGSSFNVLHTPKTDMDESSLFIKPDEFHTIFISVISTIHVDLMNQTSKKSDDPNVTITINDRETNKEMWKIRKTFSQLVIFDSEIRPIVEYFGLPPLPDKQLFVSSTPAKIETRRLALQNYFNSIFVMPHIPRMVLYYICRFLSLDFVNPLDDFKSGARKEGFLVRRYKGLGATWKIRWCQVDGPYMEIYENPGGSILEQIQLTGAQIGRQSSDAVAEDKGYRHAFLIMESSKSSKLHSSVPKHFFCAESNEERDDWVTALIEFTEDASESIENSPQQPQYHQQQQYDRSSAYDSLSTPSTRYDHTNDDLKPNSSNIFATPASIAASVADSLSTYTMGVVGGEDQSQKQKPKKRSYFPFRTKTNSSNDEPEDQHSQHSHPDNNNHLSLPNTGMINSQNTYTQQQYQQQYQPSGYPNGHQQQQQPSSSGFSGSEDNMQQYLSQMKLDEDSAKKIFGSELEIAFELSNHEFMGRKIPSICYRCLDFLMKTGAIYEEGIFRLSGSASSIRQLKDQFNTRYDVDLFQSSLKPDIHTVSGLFKSYLREMPTPIIGGNAVNHLSALVSHNTYQQQQQATGMSNSDLAIVFRDYFNDVNNVDQIHYDLSFLVFSFLRQIIQQSDINRMTLKNVGIIFEPTLNINVEVLCIFLVEFDTIFGV
Protein: Tyrosine-protein phosphatase (EC 3.1.3.48) (Q9W0R3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000927}.
Interaction partners:
- Dizzy isoform AII
Sequence:
MFERFRLNNLTRTFRLRGGGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKISRSSAAINDDED
Protein: Actin, cytoplasmic 1 (Beta-actin) (EC 3.6.4.-) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] (P60710)
Organism: Mus musculus (Mouse)
Function: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
Subcellular location: Cytoplasm, cytoskeleton. Nucleus {ECO:0000269|PubMed:23558171, ECO:0000269|PubMed:25759381}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250|UniProtKB:P60709}.
Interaction partners:
- Cofilin-1
- Actin, cytoplasmic 2
- Profilin-2
- Myosin-9
- Profilin-1
- Caspase-3
- Profilin-4
- Vinculin
- Tight junction protein 1
- Transforming protein RhoA
Sequence:
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
Protein: adenosine deaminase (EC 3.5.4.4) (Q0E8D8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRMIRLELDEEENRRQMSSSKYGGVCFHVAIAVMLCVMVLVLICSAPLGENMSNLTSEERHARLRQIYIEKERRQRLGSRMGLSPLEEEANDRLMAIRQVDEEFYNLWRNYHSQPPPFLKHLNIIDTNLYAALKSMPKGGLLHVHDSGMLRMEILIDLIYRDNLWVCVNLEQDFEDFRFSRYFPHIPPAEDYQCNWMLMSNFFQLESRLEFENRLRKTLTVRPEGYKSSSELARHLRRHQRIIHGLITFRPIWSEFIFTMLSDFYADGVHYVELRSSLPNMYDLDGNNFTILETAEALVSVSNIFKNSFKDFIGIKLIYAPSRNLNDSRMDEYLENARLLKLHFPNFFAGFDLNTFGDECNLPLLENVTQLLRIGKNIDFYFHAGESRCPDSSRPDANLLEALLLQSKRIGNAVNLPFHPEIMKVMKRLSIAVEICPLSNHYLQYFNDFRQHPAAYLIAAGFPIVIGSDYPCFWNSAPLTDDFYVAFVGVISGWGDLRLLKQFALNSFLFSSLSETEKNMAVSKWQCSWNRWVRNLVNSSGY
Protein: At5g04750 (F1F0-ATPase inhibitor protein) (F1F0-ATPase inhibitor-like protein) (Q84W11)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
- Uncharacterized protein At2g27730
- Cytochrome b-c1 complex subunit 9, mitochondrial
- Alpha-L-fucosidase 1
- Cytochrome c-2
- Tetraspanin-8
- Metacaspase-7
- Calcium-binding protein KIC
Sequence:
MSSARSAITKLKLARSFGERQIGASRSVVSTRGPAIRYFSDDKGRVLSEEERAKESMYIQKMERERLEKKKKLEQDKLDGEKGSANKKPETNKP
Protein: Neosin, isoform A (Neosin, isoform B) (SD25401p) (Q9U9Q2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSDPGSAGYNITKDPALAKSRIFLGNLPVCTREELVSICQPYGKVLGSMVQKNYGFVQFETEELANKAASALHKSTFKQNMLTVRNASIKSKAANAIAKRNSNQGGQVTVQGGLVMSAAAAAAGQPLINDCEIIVQNRENTKYAEYIEERLKNSSLRVDVLFPNEDVLLGKVLANISSRGCLYAVLVTPQHEEHNSITVNILYGVPAEHRNMPLEDAITLISTDFRLKKQRDAVVLPPSTSIHKGQRRHPQEMQGLLERLADNHPLTASQYEVILKYLEGEREEQLKREVGEANALAKLKAPDPEIELQKKILSIMNKPAVTDVTSELMYPTFEAVKEDRRLMELLADDRVLAALESVYNSDLRQILAEYL
Protein: Protein 4.1 (P4.1) (4.1R) (Band 4.1) (Erythrocyte membrane protein band 4.1) (P48193)
Organism: Mus musculus (Mouse)
Function: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P11171}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P11171}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P11171}.
Interaction partners:
- Glycophorin-C
- Ankyrin-1
- Ankyrin-2
- Ankyrin-3
- Alpha-adducin
- Gamma-adducin
- Beta-adducin
- Dematin
- Band 3 anion transport protein
- Cell adhesion molecule 1
Sequence:
MTTEKSLAAEAENSQHQQQKEEGEGATNSGQQETQLEEASQAAAAEGSDQGEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLLSSFLKRPKSQVSEEEGREVESEKEKGEGGQKEIELGNSLDEDIILKAPIAAPEPELKTDPSLDLHSLSSIETQPAQEEHREDPDSETKEGEGIEECSGTEVKEDPESRAEREPEASQKPVRRHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLALWDSATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGMDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAAESTDRSPRPTSAPAIAQSQVTEGPGAPIKKTPKEAVKVEEKRGEEPAEPAEPEPTEAWKVEKTHTEVTVPTSNGDQTQKLAGKGEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQVPTGDGPPLVKTQTVTISDTANAVKSEIPTKDVPIVHTETKTITYEAAQTEDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEISEE
Protein: Small ribosomal subunit protein eS28 (40S ribosomal protein S28) (A8DYY3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein eS19B
- Small ribosomal subunit protein uS7B
- Small ribosomal subunit protein uS11A
- Small ribosomal subunit protein eS19A
- Small ribosomal subunit protein eS10A
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS21
- Ribosomal protein S30, isoform A
- Small ribosomal subunit protein uS8B
- Small ribosomal subunit protein eS12
Sequence:
MPQPVASKARVIKILNRIGARGILTEVRVQLVDQPKMQFMRTVKGPVRLGDIVDFEDTELTWQSSSRSNSNFEDIC
Protein: Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase) (Q9P940)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15378761}.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Phosphoglycerate kinase
- Fructose-bisphosphate aldolase
- Glucose-6-phosphate isomerase
- Enolase 1
- Pyruvate kinase
- Phosphoglycerate mutase
- Dihydroxyacetone kinase
- Transketolase
- Transaldolase
Sequence:
MARQFFVGGNFKANGTKQQITSIIDNLNKADLPKDVEVVICPPALYLGLAVEQNKQPTVAIGAQNVFDKSCGAFTGETCASQILDVGASWTLTGHSERRTIIKESDEFIAEKTKFALDTGVKVILCIGETLEERKGGVTLDVCARQLDAVSKIVSDWSNIVVAYEPVWAIGTGLAATPEDAEETHKGIRAHLAKSIGAEQAEKTRILYGGSVNGKNAKDFKDKANVDGFLVGGASLKPEFVDIIKSRL
Protein: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (Leucine-rich repeat neuronal protein 6C) (Q3URE9)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLHTAIPCWQPFLGLAVVLLLMGSTIGCPARCECSAQNKSVSCHRRRLLAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIALHLKHLNINNMPVYAFKRLFHLKNLEIDYWPLLDLMPANSLYGLNLTSLSITNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWLLQRQPNLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFTSDRFLYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNMKMI
Protein: Transcriptional regulator CtsR (Q8DS13)
Organism: Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Interaction partners:
- Class III stress response-related ATP-dependent Clp protease, ATP-binding subunit
- Clp-like ATP-dependent protease, ATP-binding subunit
- Heat-inducible transcription repressor HrcA
- ATP-dependent protease ClpE
- ATP-dependent Clp protease proteolytic subunit
- Co-chaperonin GroES
- Chaperone protein DnaK
Sequence:
MTSKNTSDSIEEYIKKILAQSGFAEIKRSVLADNFSVVPSQINYVIKTRFTESRGYAVESKRGGGGYIRIAKIRFSDQHQMLNDLEATIGEQISEQVFTDIIQLLFDEKIISEREGNIILASSGDDVLGEESSRIRARMLRKILQRLDRKGYHL
Protein: La ribonucleoprotein 4B (H0Y4V9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREAGPGRVEPGSLESSPGLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFELGLSSFPPLPGAAGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVSATYERSPSPAHLPDDPKVAEKQRETHSVDRLPSALTATACKSVQVNGAATVRTSCLPSCTTAARLWCEQTLRTPAPARFLITSNLELRKPSYAEICQRTSKEPPSSPLQPQKEQKPNTVGCGKEEKKLAEPAERYREPPALKSTPGAPRDQRRPAGGRPSPSAMGKRLSREQSTPPKSPQ
Protein: Guanine nucleotide-binding protein subunit alpha-15 (G alpha-15) (G-protein subunit alpha-15) (P30678)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Interaction partners:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- B2 bradykinin receptor
- Relaxin-3 receptor 2
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MARSLTWGCCPWCLTEEEKTAARIDQEINRILLEQKKQEREELKLLLLGPGESGKSTFIKQMRIIHGVGYSEEDRRAFRLLIYQNIFVSMQAMIDAMDRLQIPFSRPDSKQHASLVMTQDPYKVSTFEKPYAVAMQYLWRDAGIRACYERRREFHLLDSAVYYLSHLERISEDSYIPTAQDVLRSRMPTTGINEYCFSVKKTKLRIVDVGGQRSERRKWIHCFENVIALIYLASLSEYDQCLEENDQENRMEESLALFSTILELPWFKSTSVILFLNKTDILEDKIHTSHLATYFPSFQGPRRDAEAAKSFILDMYARVYASCAEPQDGGRKGSRARRFFAHFTCATDTQSVRSVFKDVRDSVLARYLDEINLL
Protein: Transcriptional activator of sulfur metabolism MET28 (Methionine-requiring protein 28) (P40573)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as an accessory factor in the activation of sulfur amino acids metabolism genes. Possesses no intrinsic transcription activation abilities. Binds to the MET16 promoter as a complex with MET4 and CBF1. Enhances the DNA-binding activity of CBF1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Centromere-binding protein 1
- Transcriptional regulator MET31
- Transcriptional activator of sulfur metabolism MET4
- Transcriptional regulator MET32
- Sulfate adenylyltransferase
- Adenylyl-sulfate kinase
- Phosphoadenosine phosphosulfate reductase
- Homocysteine/cysteine synthase
- Glutamate--cysteine ligase
- F-box protein MET30 subunit MET30)
Sequence:
MSAKQGWEKKSTNIDIASRKGMNVNNLSEHLQNLISSDSELGSRLLSLLLVSSGNAEELISMINNGQDVSQFKKLREPRKGKVAATTAVVVKEEEAPVSTSNELDKIKQERRRKNTEASQRFRIRKKQKNFENMNKLQNLNTQINKLRDRIEQLNKENEFWKAKLNDINEIKSLKLLNDIKRRNMGR
Protein: Leucine-rich repeat and fibronectin type-III domain-containing protein 2 (Q80TG9)
Organism: Mus musculus (Mouse)
Function: Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity). May play a role in redistributing DLG4 to the cell periphery.
Subcellular location: Membrane {ECO:0000269|PubMed:16828986}; Single-pass type I membrane protein {ECO:0000269|PubMed:16828986}. Synapse {ECO:0000269|PubMed:16828986}. Postsynaptic cell membrane {ECO:0000250}.
Interaction partners:
- Disks large homolog 4
- Disks large homolog 3
- Disks large homolog 1
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2A
Sequence:
METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHIGRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADDAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASLLTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDDDLETCGSPGSLKGRYFWHIREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDILITTSQDSGPFTCIAANAAGEATATVEVSIVQLPHLSNSTSRMAPPKSRLSDITGSSKTSRGGGGSGAGEPPKSTPERAVLVSDVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVILMVRYKVCNHDTPGKMAAATVSNVYSQTNGSQPPPLGGIPVGQLPQAPPKVVVRNELMDFSTSLARACDSSSSSSLGSGEAAGLGRGPWRLPPPAPRPKPSLDRLMGAFASLDLKSQRKEELLDSRTPAGRGAGTSSRGHHSDREPLLGPPATRARSLLPLPLEGKAKRSHSFDMGDFAAAAAAVPGGYSPPRRVSNIWTKRSLSVNGMLLPFEESDLVGARGTFGSSEWVMESTV
Protein: Thioredoxin domain-containing protein 8 (Spermatid-specific thioredoxin-3) (Sptrx-3) (Q69AB1)
Organism: Rattus norvegicus (Rat)
Function: May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}.
Interaction partners:
- Vomeronasal type-1 receptor.
- Peroxiredoxin-5, mitochondrial
- Olfactory receptor
- Olfactory receptor
- Olfactory receptor
Sequence:
MVQKIKSMREFKELLGAAGNRLVVVEFSAQWCGPCKMIAPAFQAMSLQYRNVMFAQVDVDSSQELTEHCSIQVVPTFQMFKHSRKVTPFSRLKRILCCFRSGPGSKKIFEFQGADIEKLEEKIQELM
Protein: Putative transcriptional regulator cudA (O00841)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Essential for normal culmination. May function as a transcriptional regulator.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:9226443}.
Interaction partners:
Sequence:
MNQSQNFHNIDLGHYGAQGSNQSFNNNNNGNNGMMMNQQQMQQHVVPHLHHLQQQQQQPQQQQLRNVPDYSNSPNGTTNGSTMSPNCINTNNNNNNNNNNNNNSNNNNNNNNNASNNLTSNKSSSTNTPQIGQLQASPANLTNSPSAISSPITISNNSSLNSPSTTSSPNLLLNGTSNKRIMISQQTCLVEEKFSKNGVQKNVHVVVKNNPFLLTLSLLDSSLNFHQLTPEVQLVYDSESLKEVDSATVKPLEYKTRANEEGDQLTIELRIKVLSSQLEDMLFRAKVKIVDPRTRKETHGLSVITHPIRVVSKPDQVKKKAKKRKRAPTDSLMDTLNRIEHQQKEQQRLLKKLCYHDKENNIIQLIQQQQQQQQLLNNVTNNINNNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTSTTTTTTTTTSSCNNNNNNNNENNEHIVKIENTECNNNNNNIINNTENDENINKPILNSKDEFQSAFKEFIGAFKQLQCLDPDGADGAFKINTCANDAQTMCEILEMVKVELKKDENFKDKCGGSSGGACGENNPDNPCSCKVCPYKQKVDHINQSYETYFNMFNPSNSNSVVPQQSQQLQQQQIQQQQQSQQQVQQQQQQQMQQQPQQQQQQPQQQQQNQQQGQQPQQQQQQGQLDYTTYIDPQLQMQQQLQMQQAAQQQYMQQTMDQQQQQQYYMQQYHLQQQQQQQQAQRYLMQQQYMQQQAQQQQQQHQQVAIQQQQQQNQQQNQQQNQQQQNQSPQNQQSLDFQNANNFIDFNSGLGFMNFPNINFGDMGFSAV
Protein: Putative antitoxin VapB7 (O06777)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC7.
Interaction partners:
- Ribonuclease VapC7
- Ribonuclease VapC43
- Antitoxin VapB43
Sequence:
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALRARRG
Protein: Merozoite surface protein 8 (Q8I476)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Merozoite surface protein 1
- Merozoite surface protein 6
- Merozoite surface protein 3
- Merozoite surface protein 4
- Merozoite surface protein 5
- Merozoite surface protein 2
- Gametocyte-specific protein
Sequence:
MVFKSSYIFFFLFLVILYFNNVVEGENGTTNIENNPGNNGNMGPSGPKDKDKNIEKDVNHNMSMNNNNNNNNNNNNNDNNNNINNNNNNNINNNNNNNNNNGNGFSNFFNKLFGKKKDNKKEGEEKNEEDLNSNKNIESNKGSAVTSNVGDTNNDAKARDNNNNDDNDDNDENDDNDDNDDIDEIDERDDNDDNGDDDDDNDDDDDNNDNNNKNNSNNLTDTKKEGEKIDLGVQNKKQNIFSTNNKGLNKYNIDNELKEVDALLKNDNYILNKYHVSFFNNFEEDTYNKKKFIRPYDLSLLKSILIYRQRVTRNCVNVFQDFNAVFGKCYNKDDTKLSITRDKVKKELSRKNRNFVEYLIEMLENTLNSMNDDFINKDNFDLNNYVKEFELINYLLIHEDSDIFLETYNLISGLNSNIEETSIEKLKYAILQGKQINYKIKDDIYYILKNAYAKYFKIDVYKKGKLLYPTLYYHRNAFIKSFVVEFFNNNKVCENTKCPLNSNCYVIDDEETCRCLPGFNNIKIDDEMNCVRDDTLDCSRNNGGCDIHAKCSFINKQIVCECKDKFEGDGIYCSYSFFSSIHNFIFFFILCLFIFIL
Protein: Pleckstrin homology like domain family B member 2 (E9PFQ4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIK
Protein: Transmembrane protein (Q580S7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFSAKRKDVAEALIGFLHAIFTSFYVDVFIGQYVLVGDRDENMGPTHDNGNHIDRTISSRRSDGGAIWYLALTQLLYFFLLLKNSVIFRQHASTATFSSFPLRRLSSLPVCGTLLSFCFALMWFPLDLPFLNAATSFTLLTAAYQALFARCRKFVDALSRSSLRRPEGNIACTLFAAVGVAVACWLHGIPNNPQPMRCFTTFCAVSGAVGFFACGRQKSHSNSCFGTDITEGDDGDVLQEAVWFVQQTMLRSSMKVALLLWMFQGYNGLIATSFISVFLTACHDTIPLPLRGLLLFIVFVLPQGTDTVLASFKRVVGKKRLVALLLALLAFIGFLFILVALRDHLFILHMSPTASTLSFAVLLVMHRLMIDTLSRVQSWVLRDVVEEDTVIFCRPKPMTANVQLLLDSASQLVQCVALVLTSLHLVSVSSGKSVKPFKAAWVVGCPTLVMSVVMLLIWVRWYNLEGSHLQFVKMAMRKRADGSDPVV