wanglab/gogpt-training-data huggingface dataset:
Protein: peptidylprolyl isomerase (EC 5.2.1.8) (Q387Q5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSPESSVTSLDSQPVREVEYPVGVQTEVPDTNGGLFKTVLIEGSGTKPIKGSKVTVHYVGTLESDGSKFDSSRDRGEYFEFTLGRGQVIKGWDRGVATMRVGEKAVLRCTPEYGYGAAGSPPKIPANATLLFEVELFSWTREEDISESKDKSIMKSLAVEGIDYEKPGYESKLKVDLRVYAGPHSDDQPGTLLCERLDWELTLGDTPLPPHLETCLSTMRKRESASFRIDPRLSTEHNEEFNISPGSQLTYAVELRELTTVKTWMFEGPARVEEAERRRAQGNEAVRSGKFSVAERKYRRALEFVEADSGFGSDNDESLASARKVRLVLWGNLAQALLAQGSHQECIRYCNRVLEVEPGNAKALFRRAKAYDAQSDWHEAKGDLETILQADPQNTDARVLLQRVQAQRKAYEKKQREAYKKMFS
Protein: Mitochondrial Rho GTPase (EC 3.6.5.-) (A0A8I6AGU0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004200, ECO:0000256|PIRNR:PIRNR037488}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004200, ECO:0000256|PIRNR:PIRNR037488}.
Interaction partners:
Sequence:
MRAGRVRPLRASDMKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHLSDGVADSGLTLRGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFQVFPYIPWGPDVNNTVCTNESGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAITVTRDKKIDLQKKQTQRNVFRCNVIGVKGCGKTGVLQSLLGRNLMRQKKIRDDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEAEIVCDVVCLVYDVTNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEHSVSPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHARLRCMCTCNRCTFCICQNLLNSDLLQSVKNKVFTAVLNRHVTQADLKSSTFWLRASFGATVFAVVGFAMYRALLKQR
Protein: Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) (Q13017)
Organism: Homo sapiens (Human)
Function: GTPase-activating protein for Rho family members.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8537347}. Cell membrane {ECO:0000269|PubMed:8537347}; Peripheral membrane protein {ECO:0000269|PubMed:8537347}. Note=Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. {ECO:0000269|PubMed:8537347}.
Interaction partners:
- Transforming protein RhoA
- Proto-oncogene tyrosine-protein kinase Src
- Rho-related GTP-binding protein RhoE
- Rho GTPase-activating protein 35
- Thy-1 membrane glycoprotein
- Rho-related GTP-binding protein Rho6
- Catenin delta-2
- RAC-alpha serine/threonine-protein kinase
- Cell division control protein 42 homolog
- Catenin delta-1
Sequence:
MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKIHVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVVTATDKFEKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLNWSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPWEEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYALDGKIYELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQLANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKELMTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPPYSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLAHPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHGERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYFGMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFYNGEIVETTNIVAPPPPSNPGQLVEPMVPLQLPPPLQPQLIQPQLQTDPLGII
Protein: Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) (P26373)
Organism: Homo sapiens (Human)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399, ECO:0000305|PubMed:31630789}.
Interaction partners:
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein eS24
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein eL36
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein uL15
Sequence:
MAPSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVEKKK
Protein: Serine/threonine-protein kinase receptor (EC 2.7.11.30) (Q9W629)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.
Interaction partners:
- Bone morphogenetic protein 4.
- Bone morphogenetic protein 2
- Bone morphogenetic protein 7
- Bone morphogenetic protein 6.
- Mothers against decapentaplegic homolog 5
- Bone morphogenetic protein 2a.
- Growth differentiation factor 5
- Mothers against decapentaplegic homolog
- Bone morphogenetic protein 5.
- Mothers against decapentaplegic homolog 1
Sequence:
MDLYRSCLRWLCVLLIGLLGLVEENLANVLDSMLLRNSGKVEERRETGSDAPALPQRFLWCYCYHHCPEDSTNNTCRTDGYCFTMVEEEGGAAVVTSGCLGLVGSEFQCRDTGNSKQRRALECCTDQDYCNRDLHPTLPPLRTPSYVVGDIHHIALLISVSVCSFILTFIIIFCYFRYKRHELAPRYSLGLHPDESFIPAGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVTQIGKGRYGEVWMGRWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKCTTLDSRAMLKLAYSSVSGLCHLHTEIFGTQGKPAIAHRDLKSKNILVKRNGACCIADLGLAVKFISDTNEVDIPLNTRVGTKRFMAPEVLDETLNRNHFQSYIMADMYSFGLILWEISRRCVTGGIVEEYQLPYHDHVPNDPSYEDMREVVCIKRIRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKV
Protein: ULP1-interacting protein 3 (DUP240 protein UIP3) (P39547)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:11056382}; Multi-pass membrane protein {ECO:0000269|PubMed:11056382}. Cell membrane {ECO:0000269|PubMed:11056382}; Multi-pass membrane protein {ECO:0000269|PubMed:11056382}.
Interaction partners:
- Protein-toxin resistance protein KTD1
- ULP1-interacting protein 4
Sequence:
MQTPSENTDVKLDTLDEPSAHLIEENVALPEDTFNSYWSYILNEIARCKPLMIMFLIPVCLVLLITFFHDIKGILVFLVISLILSIIILLIGITAFVSETLNKGFIIKLLVEVITRKPAVGGKEWRIIAYNMNQYLFDHGIWHTPYYFFCEHRCHKFFKSLIKQTRSNAHLSSPTNGAENTQSNTPAKEVSNEMVKPYIFSSDPVLEAYLIKAAEIHKEAEFEYWRKQYPEVDLP
Protein: GATOR complex protein NPRL3 (Nitrogen permease regulator 3-like protein) (Q9BTE2)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome {ECO:0000256|RuleBase:RU368069}.
Interaction partners:
Sequence:
MADGNEGPQSPFHHILPKCKLARDLKEAYDSLCTSGVVRLHINSWLEVSFCLPHKIHYAASSLIPPEAIERSLKAIRPYHALLLLSDEKSLLGELPIDCSPALVRVIKTTSAVKNLQQLAQDADLALLQVFQLAAHLVYWGKAIIIYPLCENNVYMLSPNASVCLYSPLAEQFSHQFPSHDLPSVLAKFSLPVSLSEFRNPLAPAVQETQLIQMVVWMLQRRLLIQLHTYVCLMASPSEEEPRPREDDVPFTARVGGRSLSTPNALSFGSPTSSDDMTLTSPSMDNSSAELLPSGDSPLNQRMTENLLASLSEHERAAILSVPAAQNPEDLRMFARLLHYFRGRHHLEEIMYNENTRRSQLLMLFDKFRSVLVVTTHEDPVIAVFQALLP
Protein: Cell death protein 6 (Candidate adapter protein ced-6) (O76337)
Organism: Caenorhabditis elegans
Function: May function as an adapter protein in a pathway that mediates recognition and phagocytosis of apoptotic cells during normal development. Promotes engulfment of cells at both early and late stages of apoptosis. Required for actin reorganization around apoptotic cells. Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15744306}.
Interaction partners:
- ABC transporter ced-7
- Cell death abnormality protein 12
- Cell death abnormality protein 1
- CED-5
- Cell death abnormality protein 2
- Ras-related protein ced-10
- Transthyretin-like protein 52
- Cell death abnormality protein 8
- Bifunctional arginine demethylase and lysyl-hydroxylase psr-1
- Cell death protein 3
Sequence:
MAKDIYKTFKRSVSGIVGGNNINGEGSSSPSTSAPQVKYRGGTGRTWIHPPDYLINGHVEYVARFLGCVETPKANGSDVAREAIHAIRFQRDLKRSEQTRETAKLQKVEIRISIDNVIIADIKTKAPMYTFPLGRISFCADDKDDKRMFSFIARAEGASGKPSCYAFTSEKLAEDITLTIGEAFDLAYKRFLDKNRTSLENQKQIYILKKKIVELETENQVLIERLAEALRANSKADYENTGPPIYPGLGPPALPLSPMPQGPPPNIPPSSIYSMPRANDLPPTEMAPTLPQISTSSNGASPSVSPASTSPSGPAPSIPPPRPPALAPPPPVAPRRNPVVSPKNSTAGLLDGLELGSAEPAKKAPSNIFDDSFDPRAGEKKSTAAEYNPFGADFLSGIQNGKEAPPSASAELLASEAIARLPKPESSSVPPKKTAAEYDAMINEVEKKLAAMSSGSFEFGQLQTGDLGGIEGESDYGTPSDRLNPKMMNLKQ
Protein: Chad (Chondroadherin) (Q7SYE5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MYTFHVLLVLVCLQFCAHTAFAAPTQCPSQCHCHGDLQHVICDNVGLKKIPRISEATRLLNLQRNNLGNLPTGGFSEMKGLISLHLQHCQIRELSGQAFKGLNKLIYLYLSDNEISTIKPGAFEDLTELTYLYLDGNQITSLPKGIFSPMINLFILQLNNNKLRELQPGTFKGAKDLRWLYMSGNELSSIQPGSLDEVENLAILTLDQNNLSTYPLLAMSKLRVVEELNLSKNPLSLIPDHAFRSFGRYMEKLHLNDMSLEKFSNAAFEGVTALKSLHLENNKLRSLPNSLEFSTIQNITLFNNPWSCTCPLTNLRKWMDTTRNRPDAVCASPANQKGKQIRDSTAFTRCKGKTKRARKGTRL
Protein: Anthranilate synthase component 1 (AS) (ASI) (EC 4.1.3.27) (P00895)
Organism: Escherichia coli (strain K12)
Function: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
Interaction partners:
- Bifunctional protein TrpGD
- Tryptophan synthase beta chain
- Tryptophan synthase alpha chain
- Aminodeoxychorismate synthase component 2
- Tryptophan biosynthesis protein TrpCF
- Bifunctional chorismate mutase/prephenate dehydratase
- T-protein
- Chorismate synthase
- trp operon leader peptide
- Shikimate dehydrogenase
Sequence:
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSGNGEALLALLDNALPAGVESEQSPNCRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFEDLPQLSAENNCPDFCFYLAETLMVIDHQKKSTRIQASLFAPNEEEKQRLTARLNELRQQLTEAAPPLPVVSVPHMRCECNQSDEEFGGVVRLLQKAIRAGEIFQVVPSRRFSLPCPSPLAAYYVLKKSNPSPYMFFMQDNDFTLFGASPESSLKYDATSRQIEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLVSRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATVQAGAGVVLDSVPQSEADETRNKARAVLRAIATAHHAQETF
Protein: Homeobox protein DLX-5 (P70396)
Organism: Mus musculus (Mouse)
Function: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:18056716}.
Interaction partners:
- Runt-related transcription factor 2
- Homeobox protein DLX-6
- Bone morphogenetic protein 2
- Melanoma-associated antigen D1
- Transcription factor Sp7
- Osteocalcin
- Homeobox protein MSX-2
- LIM/homeobox protein Lhx6
Sequence:
MTGVFDRRVPSIRSGDFQAPFPTSAAMHHPSQESPTLPESSATDSDYYSPAGAAPHGYCSPTSASYGKALNPYQYQYHGVNGSAAGYPAKAYADYGYASPYHQYGGAYNRVPSATSQPEKEVAEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSPQSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENSASWYPSAASSINSHLPPPGSLQHPLALASGTLY
Protein: Uncharacterized calcium-binding protein At1g02270 (O81916)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Probable RNA methyltransferase At5g51130
- Protein trichome birefringence-like 35
- Homeodomain-like transcriptional regulator
- Disease resistance protein
- Protein EXORDIUM-like 2
Sequence:
MQSHQNRSRLSLILRSRFIPSFSSPLSLFVVLAAVPLPIYFSGLLSGRNNKPLSVMRLNSNLASSMVESNISCTTFNILAPIYKRVDQKNHSTRESDFRTLWLARNQRILDLLLHQRSSVICLQEVWVGNEELVNMYHHQLSSSGYTIYQLARTNSRGDGLLTAIHKDHFKVVNYRELLFNDFGDRVAQLLHVKTVIPFPLNGKQDVQQEVIIVNTHLLFPHDSSLSIVRLHQVYKILEYLEAYQKENKLNHMPIILCGDWNGSKRGHVYKFLRSQGFISSYDDAHQYTDSDAHRWVSHRNHRGNICGVDFIWLCNPSDSRKPLRTSWVEAVFSIIKYQLHKASIAEDDAFTFLGAKNHSDSLTYSDFCLALQKVNLTGIPHGLSFEETKELWVRADLDGNGVFDYEELKKIWNMTMVNQPGNCKESVMESKKEEGEDEAIGLKVNKAILFPQEAEKGLWPENYNISDHACLTVQFSPVKMLCS
Protein: Glutaredoxin-like protein NrdH (P0AC65)
Organism: Escherichia coli (strain K12)
Function: Electron transport system for the ribonucleotide reductase system NrdEF.
Interaction partners:
- Ribonucleoside-diphosphate reductase 2 subunit alpha
- Protein NrdI
- Ribonucleoside-diphosphate reductase 2 subunit beta
- Thioredoxin reductase
- Glutaredoxin 1
- Anaerobic ribonucleoside-triphosphate reductase-activating protein
- Anaerobic ribonucleoside-triphosphate reductase
- Ribonucleoside-diphosphate reductase 1 subunit alpha
Sequence:
MRITIYTRNDCVQCHATKRAMENRGFDFEMINVDRVPEAAEALRAQGFRQLPVVIAGDLSWSGFRPDMINRLHPAPHAASA
Protein: Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (A0A8I5ZTN5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAASGDPACAESYRSPLAARYASHEMCFLFSDRYKFQTWRQLWLWLAEAEQTLGLPITDEQIQEMRSNLSNIDFQMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNAFDLLLPKLARVISRLADFAKERADLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDELRFRGVKGTTGTQASFLQLFEGDHQKVEQLDKMVTEKAGFKRAYIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMSLTMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILTTLQNVSEGLVLYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAAAVVKQEGGDNDLIERIRADAYFSPIHSQLEQLLDPSSFTGRAPQQVHRFLEEEVYPLLKPYGSVMAVKAELCL
Protein: Period circadian protein homolog 2 (Circadian clock protein PERIOD 2) (F1QUT1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cryptochrome 3
- Cryptochrome-1
- Nuclear receptor subfamily 1 group D member 1
- Cryptochrome circadian regulator 1b.
- Cryptochrome circadian regulator 3a.
- Cryptochrome circadian regulator 5
- Cryptochrome circadian regulator 3b.
- Protein timeless homolog
- Cryptochrome circadian regulator 4
- Cryptochrome DASH
Sequence:
MSKDLDSKPYLFSSLEGQDGAIGCSSMATLHRMASFAEGTELGLASEGSDSSQDRPTSGHNTRKMSHSLHEDVEMKSSSGSSGSGTESHGNESHGNESHGNESHGNESSGSSNSRSKDSALLVSSGSNKSSNSHSPSPPSSTNAFSLLSASSEQDNPSTSGCSSEESAKAKTQKELIKTLKELKLHLPAEKRNKGSKSTTLNTLKYALRCVRQVEANEEYYQLLMINDSQPSGLDVSSYTIEEIDSITSEYTLKNTDIFAVAVSLITGKIVYISDQAASILNCKRDVFKNAKFVEFLTPQDVSVFYSFTTPYRLPSWSMCTGADSSPSDCMQEKSFFCRISGGKECEADLQYYPFRMTPYLMKVQDMEHSEDQFCCLLLAERVHSGYEAPRIPTDKRIFTTTHTPSCVFQDVDERAVPLLGYLPQDLIGTPVLLHLHPNDRPTMLGIHRKILQCAGQPFDHSIRFCARNGEYITIDTSWSSFVNPWSRKVSFVIGRHKVRMGPVNEDVFAAPATAEGKCVDSDIQDITEQIHRLLLQPVHNNGSSGYGSLGSNDHLLSVASSSESNGNGTRQRHEEEDIRKAKPRSFQEICKGVHMQKNQELQSKKSPTKFVQKSPVVRPKDSAYPVNWRESQEEQRAAVQEELAFKDQTVYSYQQISCLDSVIRYLESCNVPITVKRKCQSSSNTTSSNSDEDKQRNADSSMQVSEEPAHLKEQSGLSTLEVSKKPPGSGVVSPSLTPLALPSKPESVVSITSQCSYSSTIVHVGDKKEIIEDVPSAEGTDVQGLAVPPAAVSPQNQEREAYKKLGLTKQVLAAHTQKEEQAFLSRFRELRGVHAFKADCSLYLERQKGQVTSEAVPAARSCKAGGGGAQETTTTRRGRNKKTKSKRVKPNESSDSTPSGRRPAHRPQLQGLNQTSWSPSDTSQSTFPIAYPAVMPAYPLQMYPGAGGMQPRVDPPMPGFGESQCAPDPRIPMQPIQTPYSAPLVTPMVALVLPNYMFPQVGSAPRQAFYPPKQGPFPTQPTFQTQPGFTPQASFPPQSTFTIQTQFTSQNPFSSQPTFQPQPFPFACPEDPPKAPEPELREEQSRSPTPQSMGGGGPPSPPLFQSRCSSPLQLNLLQLEETQRSADRQENTAPSAVPLNNCSTGVEKAGSVTAQSKPVKDVVQDEGSPVDGQHSDALSSSSDLLDILPEDSRSGTGSATSGSMGSGSNRCGTSASGGSASRTESSNKSNNSSNYFGSVDSSQKSHKAKGQGSGVLALDGSENLIKYVLQDPLWLLMANVDEDVMMSYQLPSRDIQKVLWEDREKLRQMQKSQPRFTDEQKRELADVHPWMRRGGLPKAIDIKACMGCEELSEALNEDDPPDLHMGEAENSDVTAAPNSQELQEPPNSPTHSCPGPDT
Protein: Potassium channel KAT2 (Q38849)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Highly selective inward-rectifying potassium channel. This voltage-dependent channel could mediate long-term potassium influx into guard cells leading to stomatal opening. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. The channel activity is enhanced upon external acidification.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Aluminum-activated malate transporter 12
Sequence:
MSISCTRNFFKRFCVEEYNMDTFKHSSFLSADLLPSLGARINQSTKLRKHIISPFDPRFRGWEMWLVILVIYSAWICPFEFAFITYKKDALFIIDNIVNGFFAIDIILTFFVAYLDSHSYLLVDKPKKIAIRYLSTWFAFDVCSTAPFQSLSLLFKYNGSEIGFRVLSMLRLWRLRRVSSLFARLEKDIRFNYFWTRCTKLISVTLFAVHCAGCFAYLIADQYHDPTKTWIGAVYPNFKETSVWSRYVTALYWSITTLTTTGYGDLHAENPREMLFFVFFMLFNLGFTSYLIGNMTNLVVHWTSRTRNFRDTVRAASEFASRNQLPPNIQDQMLSHICLKFKTEGLKQQEALNGLPKAIRSSIANYLFFPIVQNVYLFHGVSRNFLFQLVSDIDAEYFPPREDVILQNEAPTDLYILVSGAVDFTVYVGEEDQVQGKAVVGDAFGEIGVLCYTPQPFTVRTTELSQILRISKKSLMSAMRAHVEDGRVIMNNLFMKLRGQQSIAIDDPNSEPESLLKEWLVGGSKTGEGNASDQGHGHKYLQLHDSENIDMGSTEWRDSRRSGYGETKRVREHTIEIEEGEKPNKEFDGKGCSDADLTSFEFHSQEAYPYCRSNIQIKQHEAAKPKDKRVTIHLKSRDKDLSKLIILPASIEELLRLAGEKFGYSFTKVTNAENAEIDDEDVIRDGDHLYILINENS
Protein: Meprin A subunit alpha (EC 3.4.24.18) (Endopeptidase-2) (MEP-1) (P28825)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Lysosomal Pro-X carboxypeptidase
- Meprin A subunit beta
- Angiotensin-converting enzyme 2
- Dipeptidyl peptidase 4
- Neprilysin
- Transmembrane protein 174
Sequence:
MLWIQPACLLSLIFSAHIAAVSIKHLLNGSDHDTDVGEQKDIFEINLAAGLNLFQGDILLPRTRNAMRDPSSRWKLPIPYILADNLELNAKGAILHAFEMFRLKSCVDFKPYEGESSYIIFQKLSGCWSMIGDQQVGQNISIGEGCDFKATIEHEILHALGFFHEQSRTDRDDYVNIWWDQIITDYEHNFNTYDDNTITDLNTPYDYESLMHYGPFSFNKNESIPTITTKIPEFNTIIGQLPDFSAIDLIRLNRMYNCTATHTLLDHCDFEKTNVCGMIQGTRDDADWAHGDSSQPEQVDHTLVGQCKGAGYFMFFNTSLGARGEAALLESRILYPKRKQQCLQFFYKMTGSPADRFEVWVRRDDNAGKVRQLAKIQTFQGDSDHNWKIAHVTLNEEKKFRYVFLGTKGDPGNSSGGIYLDDITLTETPCPAGVWTIRNISQILENTVKGDKLVSPRFYNSEGYGVGVTLYPNGRITSNSGFLGLTFHLYSGDNDAILEWPVENRQAIMTILDQEADTRNRMSLTLMFTTSKNQTSSAINGSVIWDRPSKVGVYDKDCDCFRSLDWGWGQAISHQLLKRRNFLKGDSLIIFVDFKDLTHLNRTEVPASARSTMPRGLLLQGQESPALGESSRKAMLEESLPSSLGQRHPSRQKRSVENTGPMEDHNWPQYFRDPCDPNPCQNEGTCVNVKGMASCRCVSGHAFFYAGERCQAMHVHGSLLGLLIGCIAGLIFLTFVTFSTTNGKLRQ
Protein: Survival motor neuron protein 1 (Q9W6S8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites.
Subcellular location: Nucleus, gem {ECO:0000250|UniProtKB:Q16637}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q16637}. Cytoplasm {ECO:0000250|UniProtKB:Q16637}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q16637}. Perikaryon {ECO:0000250|UniProtKB:Q16637}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q16637}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P97801}.
Interaction partners:
- Gem-associated protein 2
- Probable ATP-dependent RNA helicase DDX20
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D1
- Gem
- Small nuclear ribonucleoprotein Sm D2
- Gem
- Gem
- Chloride channel, nucleotide-sensitive, 1A.
- Small nuclear ribonucleoprotein G
Sequence:
MANGAEDVVFCRGTGQSDDSDIWDDTALIKAYDKAVASFKNALKGEDGATPQENDNPGKKRKNNKKNKSRKRCNAAPDKEWQVGDSCYAFWSEDGNLYTATITSVDQEKGTCVVFYTDYGNEEEQNLSDLLTEPPDMDEDALKTANVKETESSTEESDRSFTPQKSGHAKHKSKSNFPMGPPSWFPSFPPGPPPPPPHFKKMDGRRGEGPGPSFPGWPPMIPLGPPMIPPPPPMSPDFGEDDEALGSMLISWYMSGYHTGYYMGLRQGRKEAAASKKSHRK
Protein: Securin (P40316)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESP1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESP1.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- APC/C activator protein CDC20
- G2/mitotic-specific cyclin-2
- Separin
- Sporulation-specific protein 12
- APC/C activator protein CDH1
- Serine/threonine-protein kinase RAD53
- Protein phosphatase PP2A regulatory subunit B
- Serine/threonine-protein kinase MEC1
- Anaphase-promoting complex subunit CDC23
- Anaphase-promoting complex subunit CDC16
Sequence:
MMPANEDKENNIVYTGNESSGINFPQTPAHLLKRSHSNILKPPVRLDQLKRDANSNNGNTLKYIQGGKEVSPTKRLHTHAQQQGRLPLAAKDNNRSKSFIFPETSNQSKDADLPQLQNTLSIRKNDQLRKLSQISRSRSRANHNDLLSNSRKLQKYGSVLGYNALPKMKSLVLKDLADSGKNEESSDDDEGNEDSESKLGKKLQSALLKQDSSDGENELNGGLGLFNEQGGLQQLIKNSTKNEQKTKNDKSDKTDDYDIEIAPQRQEPLPYVPEGYSPFQQDDIEKLKTFNSPYKLDLEDEDDTPDKVDLLPLEQIDEEGEKDETECITRNQEEGAALPLLSKNFKEVAAVPTMELVYSEEGLDPEELEDLVT
Protein: Cysteine-rich motor neuron 1 protein-like (G5EF34)
Organism: Caenorhabditis elegans
Interaction partners:
- Ubiquitin-like domain-containing protein
- Repulsive guidance molecule B homolog drag-1
Sequence:
MQWSSSIILLFTFLIISNAKNQKTTLCGTCDKDSCPDVSGCEQLKKDQCDCCEVCIRQIGETCDGPGLVCDSHLSCHQENDLDGSSRCKERMHDDCLKAICPLVFHKGCPSDSQLITVSPAPGNCCPPPGSCHCDQKKCVPSVPTCTKEERLVMVEKGSDIPGKCCAYYECHKKEKKCENVHCPPMFQDEEECPPDSIRPPESISKESCCPIRQSCKCRGSICRPAQCPDGKVVNVTKKGTGFPGRCCDKWECVDAELSKAKCNHSGIERQPLETWHVSDCESCQCIRGVSVCNKMTCPKVNQECTWIGIPTGECCPVCLGCQTDNQTKLERGATWQKDDCTSCTCSELGAHMCEKYMCKTDCENPRKVEGQCCPVCDEPTIIRPPATCPSLELCSLRCANGLRRDNIGCYVCECLPDEVPTNPRCRELNDENCEKQCAHGYLKDEDGCTVCKCSKCPPLHQCHKHCLYGFETNSAGCSLCKCRASSKLDKKQGTTKSTKLGAGSAQQTEYHSEKCISFSNDGHQIVRDGGEWWSDGCRHCFCENKQEFCSLISCPTKPSDCADEKWVQKEDECCPSCIDQKKKPKSSNSLAAQKHEHTVCQSPGTGRLFTDGETWQLAPCVSCTCRVGHVLCRTTECPPIACPNPEYQNEEDCCPTCPEQKVENTKNEKGDTIVCTDDAGTAHIVGSSWRQDDCTSCVCSAEGSADCYKEACDESLECRGNPLVIKGKCCPVCSDALSSSAVCSYQSSVYAIGEQWQDGRCSNCSCVTGGQTVCRQMVCPHCDDPVPIEGHCCPLCKDAKWSPYGYGNGSASFPTSLGPRVDDGNGSSATSLIVVSLMSLCVVALIIVLMLLYKRNKKSNKLHKFNEVGQIASGGASTVRLSASKTIGSMPRLVDWKDTREESTEELLKTSTNHVRHDSQNSDDQSDSLLSTMSDTSTAPSTISSSGHVPISDTQPLTPKHRYPV