wanglab/gogpt-training-data huggingface dataset:
Protein: Serologically defined colon cancer antigen 8 homolog (Centrosomal colon cancer autoantigen protein) (mCCCAP) (Q80UF4)
Organism: Mus musculus (Mouse)
Function: Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12559564, ECO:0000269|PubMed:20835237}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q86SQ7}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q86SQ7}. Cell junction {ECO:0000250|UniProtKB:Q86SQ7}. Note=Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle. {ECO:0000250|UniProtKB:Q86SQ7}.
Interaction partners:
- Serine/threonine-protein kinase PLK1
- Centriole and centriolar satellite protein OFD1
- IQ calmodulin-binding motif-containing protein 1
- Centrosomal protein of 290 kDa
- Ninein
Sequence:
MAKSPGNSTLEDSLGQYQRSLRERANRSIHQLKCALREVDVTVEEDALDPSTSINVENEDTGVAWHELQHSHAVNQLKALLRQQTNKENETSPPRRRKLSPSRPSECDDGSMPTMHNLVPIINDQSQYIHHLEAEVKFCKDELSGMKNRVQVVVLENERLQQELKSQRPEETLREQTFLDASGNMQNSWIMTREDSRVDEAAKRPFSHGDAETGKTASTGDANKWKLELERLKLTYEAKTDLLESQLMLLRKDLAEYQKTCEDLKERLKHKESLLAASASSRVGGLCLKCAQHEAVLSQTHSNVHIQTIERLTKERDDLMSVLVSVRSSLAEAQKRETSAYEQVKHAVQMTEEANFEKTKALIQCEQLKSELERQTERLEKELASQQEKRAVEKEMIKKEVAREREDAESKMLILSQNIAKLEAQVEKVTREKTAAVSHLEEIQNHVASQEMDVTKVCGEMRFQLNKTKMEKDEVEKEHREYKAKSHKDLEMKVQEIEKLRLELSESEQHVEQEQQKAARARQECLRVTELLGEAERQLHLTRLEKDSIQQSFSNEAKAQALQAQQREQELTQKIQQMETQHDKTESEQYLLLTSQNTFLTKLKEECCLLAKKLEKVSLKSRSQIVRLSQEKRYLCDKLEKLQKRNDELEEQCIQHGRVHETMKERLRQLDKHGQATAQQLVQLLNKQNQLLLERQNLSEEVARLRAQLPSMPQSDC
Protein: Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) (O15327)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles. The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival.
Interaction partners:
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Inositol polyphosphate 5-phosphatase OCRL
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
- Phosphatidylinositol polyphosphate 5-phosphatase type IV
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
Sequence:
MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT
Protein: Exportin-2 (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) (A0A384NKW7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNNATLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIASAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKKICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAASVTLL
Protein: (thale cress) hypothetical protein (A0A178UGU3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAGLEKNADFSGKTTKSATTTSFFNRSLTIHGRTVVDSGPKSHNLNPSLNRTTSITKFYTPVESMGTSLKGKVKNLCRLFETSKPVKPALAEIPQKQKSGKSLLPESRISPFSSLNNSVIRLPGTEDRIVVYFTSLRGIRRTYEDCYAVRMIFRGFRVWIDERDVSMDIAYRKELQIAMGEKSVSLPQVFIMGKYVGGADVIKSLFEIGELAKILKEFPMRQPGFVCHCCGDIRFVPCSNCSGSKKLFDEDEDRVKRCPECNENGLIRCPDCSS
Protein: Cell wall / vacuolar inhibitor of fructosidase 1 (Invertase inhibitor) (O49908)
Organism: Nicotiana tabacum (Common tobacco)
Interaction partners:
Sequence:
MKNLIFLTMFLTILLQTNANNLVETTCKNTPNYQLCLKTLLSDKRSATGDITTLALIMVDAIKAKANQAAVTISKLRHSNPPAAWKGPLKNCAFSYKVILTASLPEAIEALTKGDPKFAEDGMVGSSGDAQECEEYFKGSKSPFSALNIAVHELSDVGRAIVRNLL
Protein: Crumbs-like protein 2b (Protein crumbs homolog 2b precursor) (Q1A5L1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDFGRMCLQYKRAVLLSLMFKLGLFCTVSSEVCLSSPCQNNSTCVPTLDGYLCTCSSSPPIYTGPNCERLLDPCDSAGCPSTCIATPGSQNYTCLCPDGFSGPNCTQNINECHSNPCSGVRSFCVDGVNGYSCHCPSGYSGADCGTRVRDCSDDPCFNNATCVWAPDGYECHCAAGFRGRNCEEDIDECLSQPCRNGAICQDAVGVYQCYCVPGFQGFHCEIDINECASQPCENNGTCVNGRDRYICECLFGFTGLNCEVDVDECEASPCQNGAVCHDHVGLYTCECVPGYEGINCELDIDECESSPCRHGGVCLDMVNGYECDCSGTGFMGFFCDIDIPECSSDPCQHGATCLEGVNHYTCICWTGYEGVNCELDVDECVSQPCENEGQCFQRSDSSLYRVLPELDTDFSFQSAAGYLCQCVSGFTGENCSVNVNECESAPCENGGSCEDLVNAFQCSCPPGFAGAVCETELDECESDPCQNRGRCEDSINAYICHCPPAEPGHLPWGGPDCSVQLTGCVDQPCQNNATCIPSIQHQQHQHTCRCPSGFHGTHCQTSTTFSITRGGYLLIDLHHKNNRSRRYLDSHVPSVQLRFRTTLQDGVIFFRGGQNHFFVLELIAGELYCRAQSGDLKLFVKLNGDFGDGFWRGVSVSVDEGLTVLSEGEMGEDGGHNQLLSFQPQGLETLYVGGVPQEWMNLTLSRTGFVGCLEDLVVDSEPVLPQSLVPLQEVQMGCERTEWCRVNPCSDHGRCVDLWSNYTCVCHRPYYGEHCSEEHTSWTFSHERNRSFAAFPIMQNHSRDVTVSLWLRSRHLNGLVLQLQHDNQPYLTLFLKNGSLYISIYSSIRRASDFLTNGEKLFMSIKTEPGVILFNQTQRIPMIYSGFEVQVGDVVYLGGLPEGENSALWGGYFKGCLQDVRIDDTQLFMYSGSISQKPQHANYLPRNSSNVLEGCVGDQTCKMKPCLNGGKCQVIWNDFMCLCPLNFSGKTCETRVWCVSDPCDPRTRCVDLPDGYECLANATFENNALKFSANGSFFEPVMRISMDLRTREENGTILRSSNGIEFFCMGLLNSSIIVKFRDSNSLEVHAFISDVTVSDGEWHKVELYASSSRISAFRWHMSIDGNPAGFSLSPAGNVDFFNSSTVMLAENYTGCLGEVRIGGVHLSFFGPLNEEAPQKTQFIRIGGMLEPHLGCIGSPLCLSEPCLNNGTCTDLFNLAVCKCAPGWTGERCQENIDECGEQPCVQGSCQDLLGDYECRCPVGFGGKNCDVEVDQCKDHQCENGGSCVATVSGYTCVCLPGHTGPYCRWRFPPRECDVDLQCENGGVCSEGSWGANCTCRPGFTGVRCELDIDECVSEPCLNGGSCVNRHNLYFCECLPDFSGENCQITKQLQQELWPWLLLLVPLAGLSVLLAALALLCLIFSARMKRRSEGTYSPSRQEAAGARMEMGSVLKVPPEERLI
Protein: Histone acetyltransferase of the MYST family 1 (EC 2.3.1.48) (Histone acetyltransferase of the GNAT/MYST superfamily 4) (MYST-like histone acetyltransferase 1) (Q9FLF7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac). Essential for gametophyte development. Involved in DNA repair after UV-B exposure. Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin.
Subcellular location: Nucleus {ECO:0000269|PubMed:17877703}.
Interaction partners:
- Histone H4
- SWR1-complex protein 4
- Histone acetyltransferase subunit NuA4-domain protein
- Protein MRG2
- Protein MRG1
- Phosphotransferases/inositol or phosphatidylinositol kinase
- Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein
- RuvB-like protein 1
- Enhancer of polycomb-like protein
- Actin-related protein 4
Sequence:
MGSSADTETAMIIATPASNHNNPATNGGDANQNHTSGAILALTNSESDASKKRRMGVLPLEVGTRVMCQWRDGKYHPVKVIERRKNYNGGHNDYEYYVHYTEFNRRLDEWIKLEQLDLDSVECALDEKVEDKVTSLKMTRHQKRKIDETHVEGHEELDAASLREHEEFTKVKNIATIELGKYEIETWYFSPFPPEYNDCVKLFFCEFCLSFMKRKEQLQRHMRKCDLKHPPGDEIYRSSTLSMFEVDGKKNKVYAQNLCYLAKLFLDHKTLYYDVDLFLFYILCECDDRGCHMVGYFSKEKHSEEAYNLACILTLPPYQRKGYGKFLIAFSYELSKKEGKVGTPERPLSDLGLVSYRGYWTRILLDILKKHKGNISIKELSDMTAIKAEDILSTLQSLELIQYRKGQHVICADPKVLDRHLKAAGRGGLDVDVSKMIWTPYKEQS
Protein: Uncharacterized protein (Q38D52)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTSLPSPALEEKRQQEHGAFLPPQFSVPMRAPVDGFPSEKDVIVPEVIRLCSKSSDGTGNARVYHGKEMLLNASPTLELPAEDAEALLTALRRHPRCAEIREELKGVNESYLEEAFGEEDAREDDTRRRVDYNAALAIMKSNSSKRLSMCTSCLTRGQHRHYYSWVKRYLEEGIIPNPTEDYPDLSTVIDLVQREQAAYRHKLKEEMIACEACKCETGYNKRTRSDEMPQQSHRACWNHNYIDEYVEQYAKQWLRYRLESQLLRGLLGGSSCGGGGGGVNFSEVICDLRKSIAASTGVKPTATLCERTRHLCAHRVAETIEERQSKGHTRVLPSAAVPPTLPLGVQWLNEREPALHTSNVAGAKVVEKDVSSQGQQQQEVAEARPPALPCKDIVGTFFTLRVCKSALFKLATAHLSSFRGEFCIPVSCTWSPSAQCLDISIEKPLPPSCESRRNISAMAMKRLVDAELRLPTRGRCSGPDGGESKCYSEVSFGADLAFLCMTNCVFDLKEPKPVFRLVKMEYNCKGYNTAPDDERTLLYENFSKKEVIYMWVLLHCNPTAALYVYRVNAYSSAVVGIEQFSSATLANQVLHEYSNDTEVQSAWSCLRDILSKLVATATRQYHQRERQHQEGMDEKSGNPEGCTFLLRKAKGHSEVSLCSVSSCYPTEPSVQDAVESFIEPAGQSVCRREYLPPCVWPFPDRIPFTYGPAPRACYTVNRTTEQRHNSEYYAKNDVWEHNLRYYTVGADGILWEQHLADGP
Protein: Hypoxia inducible factor 3 subunit alpha (M0R104)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
Sequence:
MRPAAGAARRPRCCTSWLTRCPSPAASAPTWTRPLSCASPSATCACTASAPQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGFHFVTQSGVQWHKHSSPQPRPPGLK
Protein: Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) (P46411)
Organism: Bos taurus (Bovine)
Function: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:7723632}; Multi-pass membrane protein.
Interaction partners:
- Amino acid transporter
- Glutamine synthetase
- Aquaporin-4
- Sodium-coupled neutral amino acid symporter 2
- 10-formyltetrahydrofolate dehydrogenase
- Glial fibrillary acidic protein
- Nestin
- Solute carrier family 7 member 8
Sequence:
MTKSNGEEARLGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVQVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQPNETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLISQESEIEKSMDSETKM
Protein: Vacuolar sorting protein 3 (F4I312)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required during embryogenesis. Believed to act as a component of the putative class C core vacuole/endosome tethering (CORVET) endosomal tethering complexes. CORVET is required for vacuolar transport of SYP22. Involved in root development. Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway (By similarity).
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:Q8WUH2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8WUH2}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8WUH2}. Cytoplasm {ECO:0000269|PubMed:29463724}. Note=Co-localizes with VAMP727, VPS18, RABG3F and RABF2B at cytoplasmic punctate structures. {ECO:0000269|PubMed:29463724}.
Interaction partners:
- Vacuolar protein-sorting-associated protein 33 homolog
- Protein VACUOLELESS1
- Vacuolar protein-sorting-associated protein 11 homolog
- Vacuolar sorting protein 18
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar fusion protein CCZ1 homolog A
- Transducin family protein / WD-40 repeat family protein
- Vesicle-associated membrane protein 727
- Pentatricopeptide repeat-containing protein At1g76280
- Vacuolar fusion protein CCZ1 homolog B
Sequence:
MSKSRAVVELTARFDLGGDDKIRALSLSPISDSQTLVYLGTYSGSLILLSLDTLTNTVSRLASVSLSPSPVESIFVLGEERGRVLALCNGYLFLLDSLLSQPAKRLGGLLKGINVIAKRVRGRDSSSTDLLPSEISTDSSSSKKFLQLLGAGNLVSDVRGNDSRHERVQQGHYVFAVAIGERMLLIELQCAEKEGLSGSFVVLKEILGIGGIKTLVWLDDYVIAGTVKGYSLISCVTGLSGVIFTLPDVSGPPLLKLLCKEWKVLLLVDNVGVVVDTNGQPIGGSLVFRRRPDSVGELSFYLVTVGDGKMEIHQKKSGACVQSVSFGPQGCGPSLLAADEAGDGNLLVVTTLSKLIFYRRVPYEEQIKDLLRKKRYRETISLVEELDSQGEISKDMLSFLHAQIGYLLLFDLRFEEAVNQFLKSEKMEPSEVFPFIMRDPNRWSLVVPRNRYWGLHPPPAPFEDVVDNGLMAIQRANFLRKAGMDTPVDEEFFSDPPSRADLLDSAIKNITRYLEISREKGLTLPVREGIDTLLMLLYRALNRVEDMENLASSGNNCVVEELETLLTESGHLRTLAFLYATKGMGAKALAIWRLFTKNYSSGLWQDSDDLVPYLHDNELIRLSGKEAAAAEAARILEEPCDPELALQHLSWIADVNPLFAIQVLTSDKRTEELSPEQVIQAIDPKKVEIIQRYFQWLIEERDYTDPQLHTSYALSLARSALECVEVQNGIQEADVPNGSEAHDSNVGSISLFEVDVRERLQAFLQSSDLYDPEEILELVEGSELWLEKAILYRRIGKETLVLQILALKLEDCAAAEQYCVEIGRPDAFMQLLDMYLDPQNGKEPMFKAAVRLLHNHGESLDPLQVLDKLSPDMPLKLASDTILRMLRARVHHHRQGQIVHNISRALDVDSRLARLEERSRHMQINDESLCDSCYARLGTKLFAMYPDDTIVCYKCYRRLGESKSVTGRDFKRDVLIKPGWLVNR
Protein: Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Metastasis inhibition factor NM23) (Tumor metastatic process-associated protein) (Q05982)
Organism: Rattus norvegicus (Rat)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity).
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Nucleoside diphosphate kinase B
- Nucleoside diphosphate kinase
- Inosine triphosphate pyrophosphatase
- dTMP kinase
- Nucleoside diphosphate kinase, mitochondrial
- CTP synthase
- Guanosine-3',5'-bis
- Nucleoside-triphosphatase, cancer-related
- UMP-CMP kinase
- Ribonucleoside-diphosphate reductase
Sequence:
MANSERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFIQASEDLLKEHYIDLKDRPFFSGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEISLWFQPEELVDYKSCAQNWIYE
Protein: THO complex subunit THP2 (O13539)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:11060033, ECO:0000269|PubMed:14562095}.
Interaction partners:
- RNA annealing protein YRA1
- Protein TEX1
- ATP-dependent RNA helicase SUB2
- THO complex subunit HPR1
- THO complex subunit 2
- THO complex subunit MFT1
- Nuclear cap-binding protein subunit 2
- Serine/arginine
- Serine/arginine
- Cell division control protein 73
Sequence:
MTKEEGRTYFESLCEEEQSLQESQTHLLNILDILSVLADPRSSDDLLTESLKKLPDLHRELINSSIRLRYDKYQTREAQLLEDTKTGRDVAAGVQNPKSISEYYSTFEHLNRDTLRYINLLKRLSVDLAKQVEVSDPSVTVYEMDKWVPSEKLQGILEQYCAPDTDIRGVDAQIKNYLDQIKMARAKFGLENKYSLKERLSTLTKELNHWRKEWDDIEMLMFGDDAHSMKKMIQKIDSLKSEINAPSESYPVDKEGDIVLE
Protein: Transcription factor 4 (TCF-4) (Immunoglobulin transcription factor 2) (ITF-2) (RITF-2) (R8f DNA-binding protein) (SL3-3 enhancer factor 2) (SEF-2) (Q62655)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Interacts with the CCAAT displacement protein (CDP2) to bind the tyrosine hydroxylase enhancer.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Catenin beta-1
- Myoblast determination protein 1
- Lymphoid enhancer-binding factor 1
- Transcription factor 7 like 2
- TAL bHLH transcription factor 1, erythroid differentiation factor
- Junction plakoglobin
- LIM domain binding 1
- Transcription factor 7 like 2
- Neurogenic differentiation factor 1
- DNA-binding protein inhibitor ID-2
Sequence:
MTSRDLGSHDNLSPPFANSRIQSKTERGSYSSYGRENVQGCHQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDTANHMGQM
Protein: Periplasmic murein peptide-binding protein MppA (Murein peptide permease A) (P77348)
Organism: Escherichia coli (strain K12)
Function: Essential for the uptake of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha-linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system.
Subcellular location: Periplasm {ECO:0000269|PubMed:9495761}.
Interaction partners:
- Oligopeptide transport system permease protein OppC
- Oligopeptide transport system permease protein OppB
- Oligopeptide transport ATP-binding protein OppD
- Oligopeptide transport ATP-binding protein OppF
- Periplasmic oligopeptide-binding protein OppA
- Probable D,D-dipeptide transport ATP-binding protein DdpF
- Dipeptide-binding protein
- Dipeptide transport system permease protein DppB
- Dipeptide transport ATP-binding protein DppF
- Murein peptide amidase A
Sequence:
MKHSVSVTCCALLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQVIRDLFEGLVNQNEKGEIVPGVATQWKSNDNRIWTFTLRDNAKWADGTPVTAQDFVYSWQRLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTAVDAHTLKIQLDKPLPWFVNLTANFAFFPVQKANVESGKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQKVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQKGPTADQRVRLALSMTIDRRLMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEELNAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVASMWKKNLGVDVKLQNQEWKTYIDSRNTGNFDVIRASWVGDYNEPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVKARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH
Protein: Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C) (P00703)
Organism: Meleagris gallopavo (Wild turkey)
Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MRSLLILVLCFLPLAALGKVYGRCELAAAMKRLGLDNYRGYSLGNWVCAAKFESNFNTHATNRNTDGSTDYGILQINSRWWCNDGRTPGSKNLCNIPCSALLSSDITASVNCAKKIASGGNGMNAWVAWRNRCKGTDVHAWIRGCRL
Protein: SH2 domain-containing adapter protein E (Q5VZ18)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MQWSPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKWFKEFPLNLKTVSERAKPGGGGGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSRLSRDSLQGLIQAAAGKGRKNSRATEEEPHRGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPSSLGPELDKGKIIKQQETVIILEDYADPYDAKRTKGQRDAERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGGPRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQHHRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPVHSKLH
Protein: Tetratricopeptide repeat protein 1 (O42668)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in promoting potassiumm ion uptake.
Interaction partners:
- Uncharacterized protein C13E7.08c
- Cell division control protein 73
- RNA polymerase-associated protein C651.09c
- RNA polymerase II-associated protein 1 homolog
- FACT complex subunit pob3
- FACT complex subunit spt16
- Transcription elongation factor spt5
- Meiotic recombination protein rec14
- DNA-directed RNA polymerase II subunit rpb1
- Transcription elongation factor spt6
Sequence:
MEGFTLETHASRIIEVPLLGQEDQSVEIDCSSLPSDATELCEILVNEQAPREFWTKFAHEYYIRGLREQAILILKSGLETLKDSESLCILNANIAAIYLSMAREAMLKKDTDLRDEQLRNVRTYLEAANNIDSKSEINVLLHGIYRILLNPTDKESLENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFKPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLAFQNVNNDSFVQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSSLIADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHASDSKPDLTKARMLLDRAFNLVGSSKLPRVVDSDLYITQARLWEKEDTKKSLGFLTRALDFLESAHMSVGPELLNNIAVLQYHLGLIPEAHGNIIKAKSVLPDANPELSLLLDYNLARCEEELGNTSVASEAYVSILEKHPSFIDARIRKCLLQLSNPNEETFKEIRHIMNADSQNLEVRAFFGWYLSKQKRRPVEDPEVRHCSQTLRHWHDDIYSLVQLGNAYMRQAREFRVHNDREKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREAIKDATTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVLSCLGRVWLQRGRESKNVDYLKESVRYATLALEKNPENPSLLFNVAFVQFQLCELIRQKPENSRTVEDLNFAMQQLDASIETFTKLVSVEHPPYSPTSIEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLSDARNKTKKRRVNRRVISEEYTFDQDSDAEGNQEEEVSRTIEEKQDNDITDNQDDNKELNLFSEEDEE