wanglab/gogpt-training-data huggingface dataset:
Protein: NAD(P)-binding Rossmann-fold superfamily protein (F4JSP1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase iron-sulfur protein 6
- At1g72040
Sequence:
MATTTNLSFAPPSYSRFAATKSQIRNPLFTSPLPLPSSFFLVRNEASLSSSITPVQAFTEEAVDTSDLASSSSKLVLVVGGTGGVGQLVVASLLKRNIRSRLLLRDLDKATKLFGKQDEYSLQVVKGDTRNAEDLDPSMFEGVTHVICTTGTTAFPSKRWNEENTPEKVDWEGVKNLISALPSSVKRVVLVSSVGVTKSNELPWSIMNLFGVLKYKKMGEDFLRDSGLPFTIIRPGRLTDGPYTSYDLNTLLKATAGERRAVVIGQGDNLVGEVSRLVVAEACIQALDIEFTQGKAYEINSVKVPQTVSLKFEQSGNGDGPGSDPQQWRELFKAAESK
Protein: Light dependent period A (LdpA) (Q8GLI4)
Organism: Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2)
Function: Functions in an input pathway to the Kai circadian clock. Probably senses the metabolic state of the cell via plastoquinone levels and informs the clock to modulate the photoperiod length (Probable). Deletion decreases the ability of the bacteria to modulate the circadian period in response to altered light regimes. Mild overexpression increases the photoperiod. Rapidly degraded in the presence of the quinone analog DBMIB (2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone), an artifical electron acceptor for photosystem II that reduces the plastoquinone pool. Partially resonsible for sensitivity of CikA to DBMIB, influences the levels of KaiA.
Interaction partners:
- Circadian input-output histidine kinase CikA
- Nitrate reductase
- Circadian clock oscillator protein KaiA
- Low amplitude and bright protein LabA
- Circadian clock oscillator protein KaiC
- Circadian phase modifier
- Single-stranded nucleic acid binding R3H
- Circadian clock oscillator protein KaiB
- Thioredoxin reductase
- NAD
Sequence:
MSASFPLEALQAGHWFKLICGASYQHLPVIRNLALTYALAGADCVDVAAEPAVVRSALAGLAAYERLTGRDRPWLMVSLNDGEDLHFRRAWFDPDRCPTDCPRPCERVCPTDAITSTGVQRDRCYGCGRCLPICPLGLIEAQAWQVDAAALLPELLDLGINAIEIHTQVGHQKEFQQLWQQLQPWLPQLQAIAISCPAHPEAIAYLWDLQELVGNTVETVIWQTDGRPMSGDIGAGTTHAAVRFAQAMLTEGPPGHVQLAGGTNAHTVAKLQELKLLAPQVSRFVAGIACGGAARTPLAELLEPLAEQQRSLEAHPEVLQAAVTTAIALVGPLKQAVGGATRSIPAFLLRTP
Protein: Cytochrome P450 26B1 (EC 1.14.13.-) (G3V7X8)
Organism: Rattus norvegicus (Rat)
Function: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43174}. Microsome membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43174}.
Interaction partners:
- Retinal dehydrogenase 2
- Retinaldehyde dehydrogenase 3
- Aldehyde dehydrogenase 1A1
- Cytochrome P450 1A2
- Cytochrome P450 1A1
- Cytochrome P450 3A
- Cytochrome P450 3A1
- Cytochrome P450 3A9
- Cytochrome P450 3A18
- Cytochrome P450 26A1
Sequence:
MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGNLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDMLSGLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
Protein: Gap junction alpha-4 protein (Connexin-37) (Cx37) (P28235)
Organism: Mus musculus (Mouse)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Interaction partners:
- Gap junction alpha-5 protein
- Gap junction gamma-1 protein
- Gap junction alpha-1 protein
- Gap junction beta-2 protein
- Gap junction alpha-3 protein
- Gap junction beta-4 protein
- Gap junction delta-3 protein
- Gap junction alpha-8 protein
- Cadherin-5
Sequence:
MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNVCYDQAFPISHIRYWVLQFLFVSTPTLIYLGHVIYLSRREERLRQKEGELRALPSKDLHVERALAAIEHQMAKISVAEDGRLRIRGALMGTYVVSVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPHIVDCYVSRPTEKTIFIIFMLVVGVISLVLNLLELVHLLCRCVSREIKARRDHDARPAQGSASDPYPEQVFFYLPMGEGPSSPPCPTYNGLSSTEQNWANLTTEERLTSSRPPPFVNTAPQGGRKSPSRPNSSASKKQYV
Protein: Probable serine/threonine-protein kinase tsuA (EC 2.7.11.1) (Tsunami) (Q55FT4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Plays a role in chemotaxis and seems to be involved in polarization.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18708585}. Note=Localized to the microtubule network.
Interaction partners:
- Protein tortoise
Sequence:
MDDDYKLIGQIGEGSFGKVYKYRKKFTGQLVACKVISKKGKNEEDILSLRQEIDILKNLSHPNIIQFISCFENKNEFTLVTEYADGDLSQIISEEKTLSVDLIQSICYQLVIALNYLHYKKVIHRDIKPQNILITSGGQIKVCDFGFAKTISSNSILLTSLKGTPLYLAPEIIQEQPYDYKADLWSLGIILYQILVGSPPFSANSLADLVHMTLESNIEIPKELNKYPDLVSLFRQLLCKNPDKRIGWPDLLYHPFVKSYNGAHVINNNNLNYNNNNNNNNNNNNNNNNGNRPITSAGGNYLNDNSSSPSISSPIQSLPLISADSLINSLNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGNINTNGYYQPLQSPTSQNFVNGIPIPILNGISNPFSVYNNNNNMNNNNNNKFNPTSPKHHQTLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQIPPPQSPKTPKVLSPKAVGISIQQQQQQQSQQQQMQQQQQQQQQQQQQQQQQQIPPQSPKVPQSPRVAPPPQSPRVLSSPRIAHSPKNSPRQTNPTSPSPSPRRNSLKSQQTPSLTNLNQALVNPSSSSSSLNSSIPTSSSTNKQIPPLSSNLNQVNLSNNINDNNNIINNNSNNNSNNINNNINNNNNNNSNNINNNINNNINNINNNNNNNSNINNINNINNNNNINSSNNNSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINSSNNNINNINNSNNNINNSNNNININNSNNNINGNRPTSGGNNDLILNNMLMNNISLSSSIESIASNNNSILVQQQLQQQQQQIQQQQQQIQLLQQQQQIQIQQQQQIQQQQQLQIQLMQQQQQLNIIQQQNSVVQNGMVVSVLNKKAPPTPITRPQTPTSFRPQTPQYRTCTPRTPQPINTPASRNNFQSNVLPSWPNLYYQQLNVNDPHQLQQLQQQQQQLQLQQQQQQQQQQQLPLSSSQQQIHYYNQMNHNGNSQNERLDEISEASESLESLEFWRFHESISFKSEENASKLRSDKQFLHKIISHLSASSFSMIERLPIGLILRTFSNIMKYGTLTIQSSNNTTLQSTRTPPQTPPLYPSFNNNGNNSNNNNNSNNSGGGNNSSEIYKFSNFQILVNVLSNILATTLHITNGNGNSGIIGSTSSNGMVLLNNPYTNLLDCLNTITMFLETFQPSLSVLFNVNGLNERHGSSSTPNQSSPCPTSPNGGSSNISINNINGGKRIHSQPQQSNQTQQINTQLMFLSILNHLTKNIFIYNQGIQIAVIKIISRLFSRLGENPYLFGEIYRKIIEQTDILQNICSYFLLLLNQSYQSSSSSTISNTSSLSSSSTSPPTSSSSSTSSSTTTPLSSSTTTAATATATTSAATTSTATNSSQQQQQQPIPSSIEVEVEIVLQCFHNILYTSPQHAFEFPLEPKRNYQTNTSIQTYLMNYYQACVIIGDGLSSEIIINLLLCSISSYPHLRKIILQLSLHCLRGSKLFAESISKEEKSLIYPINQNNNNNNNNNNNNQNKNNNNSNSNPSTPNLQFQNSYNSPYNTINNNKPRSFFDYLSIKNINQSNNNNNNNNNNNNNNNNNNNNNLNTESTIEFNQEQKSLVLLILSAILIHSKESIDWMIHYDLVDLSIRYFQNTDIRISSSASYFLSGFLTVSINYEKEFDNFNNNLNNSNNNLIRPTSPNSNNLIINGTNSLIDNQLTIIIDSIIQVIPIKNIRKLFSAKRVEGNTMRDLEGGCFGKPNIGMLDGVVCILLRMLKRGGQEFLETMLESGIWEALCHQISSTTSEIELSPHGIIHSLRVIYEVLSSDTDHIPYLVKNNLLTSLCNLLDSGHLERIKEWPSLQMGSVSGISALANQIFFILYLPLSSNAKDRIGDPMIELIRHIMLAQELVRNIIMLLPQIPSDSIDLPLGLLSNIILEDSKFANQFIEFGGLEPNTAQLILNPDRISPSTLVDSLIIFSQLARISQDNYKAMHRSDLYGLLKKLLAHPEATVRAKTCNLIGNMFKYNGYFYQHFQKSGILPILISRCIDVDLNTRKFACFALGNAAFHSSDLYDELDDSIPILKKLLNNEYPFSGQQQQQQSQQQQQSQQQQQNDLLLQIEEDEKTRSNVIGALGNLVRNSSQLCQKMIDSGILDALTSYLDEYKSHTNILKSVLFSLGNFSVYEQCRYILIEDYDLDSTLDDLFEYLKQNQQQIDPTIIKYINRIKKILRSPST
Protein: Myocardin related transcription factor A (A0A8I6AI47)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MWNCLQHGDIYSCEGGLTSNQKVVSFSQSNRGTVVPGSTSCLAAVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEALIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLESRASDLLPSATSISPTQVLSQLPMAPDPGETLFLAEQPPLPPPPLLPPSLTSGSIVPTAKPAPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDKGAPAMDSSYAKILQQQQLFLQLQILNQQQQQQQQQHYNYQAILPAPPKPSGETPGSSAPTPSRSLSTSSSSSSGTPGPGGLARQNSTALAGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQVSPAPGAPKAPATTSVLSKAGEVVVAFPAALLSTGSALVTAGLAPAEMVVATVTSNGMVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDAFGEMVTSPLTQLTLQASPLQIVKEEGARAASCCLSPGARAELEGLDKDQMLQEKDKQIEELTRMLQQKQQLVELLRLQLEQQKRAQQPAPASSPVKRESSFSSCQLSCQPQGAARAFGPGLVVPTTNHGDAQAPAPESPPVVVKQEAGPPEPDLAPASQLLLGSQGTSFLKKVSPPTLVTDSTGTHLILTVTNKSADGPGLPTGSPQQPLSQPGSPAPGPPAQMDLEHPPQPSFATPTSLLKKEPPGYEETVTQQPKQQENGSSSQHMDDLFDILIQSGEISADFKEPPSLPGKEKSPPAEAYGPPLTPQPSPLSELPQAAPPPGSPTLPGRLEDFLESSTGLPLLTSGHEGPEPLSLIDDLHSQMLSSSAILDHPPSPMDTSELHFAPEPSSGMGLDLAVGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSMDFLDGHDLQLHWDSCL
Protein: N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog) (Q5VZE5)
Organism: Homo sapiens (Human)
Function: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19398576}.
Interaction partners:
- N-alpha-acetyltransferase 30
- N-alpha-acetyltransferase 38, NatC auxiliary subunit
- N-alpha-acetyltransferase 15, NatA auxiliary subunit
- N-alpha-acetyltransferase 10
- N-alpha-acetyltransferase 16, NatA auxiliary subunit
- N-alpha-acetyltransferase 11
- N-alpha-acetyltransferase 25, NatB auxiliary subunit
- N-alpha-acetyltransferase 20
- N-alpha-acetyltransferase 50
- Small nuclear ribonucleoprotein E
Sequence:
MVMKASVDDDDSGWELSMPEKMEKSNTNWVDITQDFEEACRELKLGELLHDKLFGLFEAMSAIEMMDPKMDAGMIGNQVNRKVLNFEQAIKDGTIKIKDLTLPELIGIMDTCFCCLITWLEGHSLAQTVFTCLYIHNPDFIEDPAMKAFALGILKICDIAREKVNKAAVFEEEDFQSMTYGFKMANSVTDLRVTGMLKDVEDDMQRRVKSTRSRQGEERDPEVELEHQQCLAVFSRVKFTRVLLTVLIAFTKKETSAVAEAQKLMVQAADLLSAIHNSLHHGIQAQNDTTKGDHPIMMGFEPLVNQRLLPPTFPRYAKIIKREEMVNYFARLIDRIKTVCEVVNLTNLHCILDFFCEFSEQSPCVLSRSLLQTTFLVDNKKVFGTHLMQDMVKDALRSFVSPPVLSPKCYLYNNHQAKDCIDSFVTHCVRPFCSLIQIHGHNRARQRDKLGHILEEFATLQDEAEKVDAALHTMLLKQEPQRQHLACLGTWVLYHNLRIMIQYLLSGFELELYSMHEYYYIYWYLSEFLYAWLMSTLSRADGSQMAEERIMEEQQKGRSSKKTKKKKKVRPLSREITMSQAYQNMCAGMFKTMVAFDMDGKVRKPKFELDSEQVRYEHRFAPFNSVMTPPPVHYLQFKEMSDLNKYSPPPQSPELYVAASKHFQQAKMILENIPNPDHEVNRILKVAKPNFVVMKLLAGGHKKESKVPPEFDFSAHKYFPVVKLV
Protein: Choline dehydrogenase, putative (EC 1.1.99.1) (Q38CJ1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Intraflagellar transport protein component, putative
- Intraflagellar transport protein 56 homolog
- Intraflagellar transport protein IFT88, putative
- Uncharacterized protein
- C2H2-type domain-containing protein
- Intraflagellar transport protein 57/55
- IFT80/172/WDR35 TPR domain-containing protein
- Intraflagellar transport protein 80
- Intraflagellar transport protein A1
- Ankyrin repeat protein
Sequence:
MRCNKALHRYDAVVVGGGLAGCLVAGRLAMDNRRIAVIEEGEDIRRQPRWHRNLACSLLSHRCGGRGYESHTNVTTPQLSHEKENAPAPVMIPTPKVLGGGGVMGGRSWLIGDEADWTATPWDFRGDLLPRVQRLENVEGAGPHRGRRGRFTVGRSHAQSPLFRVFCEAMSKDTSITSDFNKKAFAVRTGCGRTESFVDPNTGVAHTTLQSYLMDAIELRRPLDVICNARVFGISSGKDDPAIATGVSYTQKGETVHVEADDVILCAGGIGTPLLLAASRGPLPIDQSVGTNFWDAPQVKLQFRTPSSLSHNCFMDPLVQAFLWPNVTYGTPISSLRSAYDDMICFWSSTGGQTPDVKFIFQPFTLNNDGSQPKNVTHGVQIIAQLLKPKSRGSICADGTINPQYFSHTDDAAVLSKAVARVKELSKVLPFSNLFSELIAEHFESAGVYGGATYPAVAPETFLVKGTRNVYACDESILPSPLLGGSLPFILALGEKFSDHYLQKLETTGKAAASEGIDAKARIIY
Protein: Kinesin-like protein KIF2B (Q8N4N8)
Organism: Homo sapiens (Human)
Function: Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17538014}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17538014}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17538014}. Note=Association with kinetochore is transient.
Interaction partners:
- Serine/threonine-protein kinase PLK1
- CLIP-associating protein 1
- Centromere-associated protein E
- Cell division cycle protein 20 homolog
- Kinesin-like protein KIF18A
- Kinesin-like protein KIF2C
- Nuclear migration protein nudC
- Centrosomal protein of 170 kDa
- Kinesin-like protein KIF2A
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Sequence:
MASQFCLPESPCLSPLKPLKPHFGDIQEGIYVAIQRSDKRIHLAVVTEINRENYWVTVEWVEKAVKKGKKIDLETILLLNPALDSAEHPMPPPPLSPLALAPSSAIRDQRTATKWVAMIPQKNQTASGDSLDVRVPSKPCLMKQKKSPCLWEIQKLQEQREKRRRLQQEIRARRALDVNTRNPNYEIMHMIEEYRRHLDSSKISVLEPPQEHRICVCVRKRPLNQRETTLKDLDIITVPSDNVVMVHESKQKVDLTRYLQNQTFCFDHAFDDKASNELVYQFTAQPLVESIFRKGMATCFAYGQTGSGKTYTMGGDFSGTAQDCSKGIYALVAQDVFLLLRNSTYEKLDLKVYGTFFEIYGGKVYDLLNWKKKLQVLEDGNQQIQVVGLQEKEVCCVEEVLNLVEIGNSCRTSRQTPVNAHSSRSHAVFQIILKSGRIMHGKFSLVDLAGNERGADTTKASRKRQLEGAEINKSLLALKECILALGQNKPHTPFRASKLTLVLRDSFIGQNSSTCMIATISPGMTSCENTLNTLRYANRVKKLNVDVRPYHRGHYPIGHEAPRMLKSHIGNSEMSLQRDEFIKIPYVQSEEQKEIEEVETLPTLLGKDTTISGKGSSQWLENIQERAGGVHHDIDFCIARSLSILEQKIDALTEIQKKLKLLLADLHVKSKVE
Protein: PPE family protein PPE6 (Q6MX48)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- PPE family protein PPE5
- PPE family protein PPE8
- Uncharacterized PPE family protein PPE62
- Outer membrane channel protein CpnT
- PE-PGRS family protein PE_PGRS16
- Uncharacterized PPE family protein PPE21
- Uncharacterized protein Rv2082
- CRISPR system Cms protein Csm5
- Probable membrane protein
- Uncharacterized protein Rv2209
Sequence:
MDFVVSAPEVNSLRMYLGAGSGPMLAAAAAWDGLADELAVAASWFGSVTSGLADAAWRGPAAVAMARAVAPYLGWLISATAQAEQAAAQARVAVATFEAARAATVHPAIVAANRAVLVSLVSSNLLGFNAPAIAATEAAYERMWAQDVAAMVGYHAGASAAVSALMPFTQQLKKLAGLSERLTSAAAAAAGPPSAAGFNLGLANVGANNVGNGNVGVFNVGFGNLGSYNLGFANLGSDNLGLANLGGHNIGFANTGSNNVGFGNTGSNNVGIGLTGNGQIGFGSFNSGSHNIGLFNSGSGNVGLFNSGTGNFGIGNSGTGNFGLGNTGSTNTGWFNTGDVNTGGFNPGSYNTGNFNTGNYNTGSFNAGNYNTGYFNTGDYNTGVANTGNVNTGAFIAGNYSNGVLWRGDYQGLIGADIALEIPAIPINAQLFSMPIHQVMVMPGSVMTIPGMRLPFTSIVPFVVYYGPVELPQSTLTLPTVTITVGGPTTTIDGNLTGMVGGVSIPLIKIPAAPGFGNSTTSPSSGFFNAGAGTASGFGNFGGGASGFWNLASATSGLSGFGNVGALGSGVANVGNTISGLYNTSTSNLATPAFNSGLLHHSVGTMTLNFGLANVGGNNVGGANAGIFNVGLANLGDYNIGFGNLGGDNLGFAHAGSYNIGFANTGSNNLGFANTGDNNIGFANIGSNNIGIGLTGSGQIGFGSLNSGSHNIGLFNSGDGNIGLFNSGSGNFGIGNAGTGNWGIGNSGAGNFGIGNAGSTNTGLFNSGDLNTGSLNPGSYNTGSVNTGSVNTGGFNAGNYNTGYFNTGDLQHRHGEHRQYQHRRFHLRQPQQRPSVAGRQPGSDRPRHRRRHSRNPDCERRREYPDSHTDHRQLHGHRIQRARSSTEHSRHCYFFRTRRYRPLHRPSDTDNRSHTCGHGGWTHYRDQYRRHCGRRRHQHPDYPYSSDSRLRQLDRRTVVGLLQ
Protein: Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) (P28741)
Organism: Mus musculus (Mouse)
Function: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:21670265}. Cell projection, cilium {ECO:0000269|PubMed:21670265}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23386061}. Note=Localizes to the subdistal appendage region of the centriole. {ECO:0000269|PubMed:23386061}.
Interaction partners:
- Kinesin-like protein KIF3B
- Kinesin-associated protein 3
- Protein smoothened
- Beta-arrestin-1
- Beta-arrestin-2
- Transcriptional activator GLI3
- Zinc finger protein GLI1
- Zinc finger protein GLI2
- Intraflagellar transport protein 88 homolog
- Kinesin-like protein KIF3C
Sequence:
MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDEEGELGEDGEKKKKRRDQAGKKKVSPDKMVEMQAKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRRRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSLMKLERPRTSKGKARPKMGRRKRSAKPETVIDSLLQ
Protein: 116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa) (Q15029)
Organism: Homo sapiens (Human)
Function: Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome.
Subcellular location: Nucleus {ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154}.
Interaction partners:
- Serine/arginine repetitive matrix protein 2
- SNW domain-containing protein 1
- Splicing factor 3B subunit 2
- U4/U6 small nuclear ribonucleoprotein Prp31
- U4/U6 small nuclear ribonucleoprotein Prp4
- U5 small nuclear ribonucleoprotein 200 kDa helicase
- Small nuclear ribonucleoprotein F
- Splicing factor 3B subunit 3
- Pre-mRNA-splicing factor SYF2
- Protein BUD31 homolog
Sequence:
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLELAKQDVVLNYPM
Protein: IkB (Q20KN0)
Organism: Carcinoscorpius rotundicauda (Mangrove horseshoe crab) (Limulus rotundicauda)
Subcellular location: Target cell membrane {ECO:0000256|ARBA:ARBA00004175}.
Interaction partners:
Sequence:
MRKSKEFKVSSEKEKSSVPHEKQGIHVRSEGTRSVVSSHSHHSPQKEYKTGYKRTMVSNQVLCDENECLSSISYETVFDSGYSSTSFQSSSSILQGDNAFFDSGMSIGTSELGIHFPEHEYFIDSDFKKESETKCGDVDVCTKFDSGLGIELGSDVDNALYSKEKTTLTPHLSETVVEDFQWQSAFHQDQDGDTLLHLAIVQETVEISLALVRFAMHPDMLDIFNHLSQTPLHLAVLTGQYRIVRRLIVAGATVDMRDRHGNTAFHIACERGDMECLRALTTPVTENEVIEANLQYPVDLQYLSPDFLEHRNYEGQTCLHLAVQQGHMDVIRYLVQCDADVNGKEGKSGRTSLHLAVEAQRDDLVQFLLNTCHADVNIQNYAGHSPLHVAWSVYQLEPTCSKLKNIVIILKNHGGEPRRPPESDVDSDSDSSGDEVRAV
Protein: Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) (Q9Y2H1)
Organism: Homo sapiens (Human)
Function: Involved in the regulation of structural processes in differentiating and mature neuronal cells.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.
Interaction partners:
- MOB kinase activator 1A
- MOB kinase activator 2
- MOB kinase activator 1B
- Protein NDRG2
- Protein NDRG3
- Protein NDRG1
- Serine/threonine-protein kinase 38
- Protein furry homolog-like
Sequence:
MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL
Protein: ORF126 ankyrin repeat protein (Q6TVJ4)
Organism: Orf virus (strain Goat/Texas/SA00/2000) (OV-SA00) (Orf virus-San Angelo 2000)
Interaction partners:
Sequence:
MADERGPDGALFRYLESEERPDVERMRRLLDEGADVNYAGPRGYAPLHMLMRGNPLDPDAVRLLLAAGADVNATSLCGFTPLHSYMCFGTVTPDTLCALMRHGARVSDLERNINALIEYFNRNGCMGGAEAAVIALLVEHGAYVNAKDDLGRTPLHIYLSGFFVSAPVALALIALGANPNATDAYGRTPLHAFLRSRDVDPAVLKTLIAAGADPLARDIIRRTALHYHCESFKTRASVIETLVAAGCDPASTDLLDNTALHSMAMGSSCRASLIRPLLAAGVSVNARNARLQTPLHLAAVFNPPACARLLAAGADPALSDLDETTPLLSMVRHNCARAVRTALPLAPDALVAGAVNRVNARTPSAATRECVMALALRGALDLLSAESARAHAAAIRACEAEVALLRRTRLGAPPTTLFSLLTGRPNTLISAKAARRAMADVCVYRAALAARVERVRRKSSLVERLTAMVCPCALPPELVTRILALLTVEELACAMRK
Protein: Spindle and kinetochore-associated protein 2 (Protein FAM33A) (Q8WVK7)
Organism: Homo sapiens (Human)
Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}.
Interaction partners:
- Spindle and kinetochore-associated protein 3
- SKA complex subunit 1
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Centromere protein F
- Biorientation of chromosomes in cell division protein 1
- Protein Spindly
- Kinetochore protein NDC80 homolog
- Serine/threonine-protein kinase PLK1
- Cell division cycle protein 20 homolog
- Nuclear migration protein nudC
Sequence:
MEAEVDKLELMFQKAESDLDYIQYRLEYEIKTNHPDSASEKNPVTLLKELSVIKSRYQTLYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL