wanglab/gogpt-training-data huggingface dataset:
Protein: Leucine-rich repeat receptor-like serine/threonine-protein kinase RGI4 (EC 2.7.11.1) (Protein RECEPTOR OF RGF1 2) (Protein RGF1 INSENSITIVE 4) (Protein STERILITY-REGULATING KINASE MEMBER 2) (F4K6B8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor with a serine/threonine-protein kinase activity (By similarity). Together with SKM1, LRR-rich receptor-like kinase (LRR-RLK) required for male fertility by the perception of CLE43 and CLE45 peptides and the transduction of their promoting action in pollen tubes, especially under relatively high temperature (at 30 degrees Celsius), thus conferring tolerance against high temperature probably through the maintenance of mitochondrial activity. Seems to not be involved in the perception of CLE45 peptide in roots. Together with RGI1, RGI2, RGI3, RGI4 and RGI5, acts as receptor of RGF1, a peptide hormone that maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT). Links RGF1 signal with its downstream components.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9ZWC8}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- CLAVATA3/ESR
- Membrane-associated kinase regulator 5
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- Protein GOLVEN 11
- CLAVATA3/ESR
- CLAVATA3/ESR
- Protein CLAVATA 3
Sequence:
MPRNPRFCFFLFLLFHSSLFFSIPCFSIDEQGLALLSWKSQLNISGDALSSWKASESNPCQWVGIKCNERGQVSEIQLQVMDFQGPLPATNLRQIKSLTLLSLTSVNLTGSIPKELGDLSELEVLDLADNSLSGEIPVDIFKLKKLKILSLNTNNLEGVIPSELGNLVNLIELTLFDNKLAGEIPRTIGELKNLEIFRAGGNKNLRGELPWEIGNCESLVTLGLAETSLSGRLPASIGNLKKVQTIALYTSLLSGPIPDEIGNCTELQNLYLYQNSISGSIPVSMGRLKKLQSLLLWQNNLVGKIPTELGTCPELFLVDLSENLLTGNIPRSFGNLPNLQELQLSVNQLSGTIPEELANCTKLTHLEIDNNQISGEIPPLIGKLTSLTMFFAWQNQLTGIIPESLSQCQELQAIDLSYNNLSGSIPNGIFEIRNLTKLLLLSNYLSGFIPPDIGNCTNLYRLRLNGNRLAGNIPAEIGNLKNLNFIDISENRLIGNIPPEISGCTSLEFVDLHSNGLTGGLPGTLPKSLQFIDLSDNSLTGSLPTGIGSLTELTKLNLAKNRFSGEIPREISSCRSLQLLNLGDNGFTGEIPNELGRIPSLAISLNLSCNHFTGEIPSRFSSLTNLGTLDVSHNKLAGNLNVLADLQNLVSLNISFNEFSGELPNTLFFRKLPLSVLESNKGLFISTRPENGIQTRHRSAVKVTMSILVAASVVLVLMAVYTLVKAQRITGKQEELDSWEVTLYQKLDFSIDDIVKNLTSANVIGTGSSGVVYRVTIPSGETLAVKKMWSKEENRAFNSEINTLGSIRHRNIIRLLGWCSNRNLKLLFYDYLPNGSLSSLLHGAGKGSGGADWEARYDVVLGVAHALAYLHHDCLPPILHGDVKAMNVLLGSRFESYLADFGLAKIVSGEGVTDGDSSKLSNRPPLAGSYGYMAPEHASMQHITEKSDVYSYGVVLLEVLTGKHPLDPDLPGGAHLVQWVRDHLAGKKDPREILDPRLRGRADPIMHEMLQTLAVSFLCVSNKASDRPMMKDIVAMLKEIRQFDMDRSESDMIKGGKCEKWQPQPLPPEKIVSTPRGSSNCSFAYSDESV
Protein: 14-3-3 protein gamma-1 (Q6PC29)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P68252}.
Interaction partners:
- M-phase inducer phosphatase
Sequence:
MVDREQLVQKARLAEQAERYDDMAAAMKSVTELNEALSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELETVCQDVLNLLDNFLIKNCGETQHESKVFYLKMKGDYYRYLAEVATGEKRAAVVESSEKSYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDEGGEGNN
Protein: Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin-1) (Q61234)
Organism: Mus musculus (Mouse)
Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate.
Subcellular location: Cell membrane, sarcolemma {ECO:0000269|PubMed:9214383}; Peripheral membrane protein {ECO:0000269|PubMed:9214383}; Cytoplasmic side {ECO:0000269|PubMed:9214383}. Cell junction {ECO:0000269|PubMed:9214383}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9214383}. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
Interaction partners:
- Dystrophin
- Dystrobrevin alpha
- Dystroglycan 1
- Nitric oxide synthase 1
- Utrophin
- Caveolin-3
- Alpha-sarcoglycan
- Sodium channel protein type 5 subunit alpha
- Delta-sarcoglycan
- Gamma-sarcoglycan
Sequence:
MASGRRAPRTGLLELRCGAGSGAGGERWQRVLLSLAEDALTVSPADGEPGPEPEPAQLNGAAEPGAAPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQALKKTGKEVVLEVKYMKEVSPYFKNSAGGTSVGWDSPPASPLQRQPSSPGPQPRNLSEAKHVSLKMAYVSRRCTPTDPEPRYLEICAADGQDAVFLRAKDEASARSWAGAIQAQIGTFIPWVKDELQALLTATGTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLFYCSLPQSREALSRPTRTAPLIATSSAHRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGIQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAMLLRQPFEKLQMSSDDGTSLLFLDFGGAEGEIQLDLHSCPKTMVFIIHSFLSAKVTRLGLLA
Protein: Amyloid-beta A4 precursor protein-binding family A member 3 (Adapter protein X11gamma) (Neuron-specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (O88888)
Organism: Mus musculus (Mouse)
Function: May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}.
Interaction partners:
- Amyloid-beta precursor protein
- Syntaxin-binding protein 1
- Peripheral plasma membrane protein CASK
Sequence:
MEFLPGPQHPPGPPTMDLEEPKGPEVPSENHPSNTQSALGPGGPVTLSEMELDTSSVQELVQQLEALPSDLGGPFPDGAPCPLHIATGQGLATQENPDAGGLLSAEAGGDDLLGLLRDEASSPAQSVPQDPAQTAPRLLQPPEDPDGDPGWMEGASAEPADSRSSSSSPEPWLETAPLVTQQEPPVGTQSRETLASCPAVTEVPGPCGPEELMDGVIFGAKYLGSTQLLSERSPAPSTRMGQAQEAMDRVKAPEGETQPMVEVDIFISTKRVKVLAADSQDALMDHALQTISYIADIGPVLVLMARRRLARRTTPQDRQRRLYKMLCHVFHSEDAQLIAQAIGQAFSIAYSQFLQENRIDPSQVGTQPSTAASHPHNGDLDHFCNSQNCREVCIQKRPGEGLGVALVESGWGSLLPTAVIANLLHGGPAERCGALSIGDRVTAINGTSLVGLSLAACQAAVREVRRLSSVTLSIIHCPPVTTAVIRRPHVREQLGFCVEDGIICSLLRGGAAERGGVRVGHRIIEVNGQSVVAMPHARIIQLLTETREIHIKTMPAATYRLLTGQEQPVYL
Protein: Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4) (Q8BUE1)
Organism: Mus musculus (Mouse)
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange (By similarity). In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:12493726}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12493726}; Multi-pass membrane protein {ECO:0000255}. Zymogen granule membrane {ECO:0000250|UniProtKB:P26434}; Multi-pass membrane protein {ECO:0000255}. Note=Enrichment at apical or basolateral membrane may be tissue-dependent. {ECO:0000305|PubMed:12493726}.
Interaction partners:
- Sodium/hydrogen exchanger 1
Sequence:
MGPAMFMAFRLWNWLLLLAVLTRSEATSYVNESSNPTAQQAPDARFAASSSDPDEGISVFELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVGGIIFGTHHKSPPVMDSSIYFLYLLPPIVLESGYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYFICQIKAFGLGDINLLHNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGISVVLYNILIAFTKMHKFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTIGKNHEWNWAFICFTLLFCQIWRAISVFTLFYVSNQFRTFPFSIKDQFIIFYSGVRGAGSFSLAFLLPLSLFPRKKLFVTATLVVTYFTVFFQGITIGPLVRYLDVRKTNKKESINEELHSRLMDHLKAGIEDVCGQWSHYQVRDKFKKFDHRYLRKILIRRNLPKSSIVSLYKKLEMKQAIEMVETGILSSVASPTPYQSERIQGIKRLSPEDVESMRDILTRSMYQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESMRKGQSLPWGKPAGTKNFRYLSFPYSNPQAARREARAAEPTDDDGTDSGFQPLMFSIHSRAGSLQERRQTQAVIPMKRLQRGEKALSFSYRSNTSWEDQAGWRRMDVLRPKPLFYAVAEEYDSGEQTEEETSAILSRWTAEHRHSTEHHKSHSPLLHRK
Protein: Expressed protein (Transcriptional activator (DUF662)) (Q9SJR4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Carboxylesterase SOBER1
Sequence:
MTQSQTNDGAGAGAVTTVESVPPQPQSQPQPQPQQQSNEMVLHTGSLSFSSHMSREDEEMTRSALSAFRAKEDEIEKRRMEVRERIQAQLGRVEQETKRLSTIREELESMADPMRKEVSVVRKKIDSVNKELKPLGSTVQKKEREYKEALDTFNEKNREKVQLITKLMEMEQLVGESEKLRMIKLEELSKSIETV
Protein: Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim) (P04141)
Organism: Homo sapiens (Human)
Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Subcellular location: Secreted {ECO:0000269|PubMed:1737041, ECO:0000269|PubMed:3925454}.
Interaction partners:
- Granulocyte colony-stimulating factor
- Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
- Cytokine receptor common subunit beta
- Interleukin-1 beta
- Interleukin-3
- Interleukin-2
- Interleukin-1 alpha
- Eotaxin
- Interleukin-5
- Interferon gamma
Sequence:
MWLQSLLLLGTVACSISAPARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
Protein: Uncharacterized protein (Q389M5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MALSPPGTFLNVLAIIVVFTVLPVLASAAENGVVVGNLDGTRRITTDDIQNGFDGGKNYMKPCVEYDYHGHNYVLIVEMGSFADHLIPLPGVTLCNLLTNMNATRNYVYAPRDPRDPAWDGYTRVVSEPLDTGVLGGSGEGYTEESGGRTLSFWGDNNDDTSHTGGCCALTPGEPAAWGRPYRLVFVPTKPALYLAWRFKPTVAVVNGPVVFEVNVWNRHSEPYQGNVTFRITANGNTTIAESPTGRYTHYAGPPAEGAREYVIVVEVVNGPETANAKILKAVLNVVGRLPADVSAYPDALVPRLLHFGEAGTAIRAVERSTALERDWFAPTVVGGEAQIRPQVGSRSMVRIDSEHFLQDVWRELAADDGVFVAKVPHRSLQFYAFSLYSAATQRVTVRYGFDATAVVYVDGKRFTPRSADPSNESSFDVSLTEGFHQVFIKLFFDQYSVNNRTELLATSKFWMRVVGTAVGYSLRGVPRMEGAAYELMDDLHVSKFLHLGKEWVDFVYGGFDGSVVDVLRVFPQPGRKVGNLTWTTLTSPDGKIPVYGVNLHKGKGSAVSYIAFSLHNGRNSFASVCWTFVTEGETDLFLDSTPAYSRGNGTERKQESVTTYLSPGWHSIILRTVAINGHSWFLSFKIHLGSCEVKGVNALGNDLPPYLTPVQAEAPVLTLMRLVKKESTVGAIPHDLEAEMSPSAQLTDFPLDSRPSSMILSTESVWVLGERRQYEWVAERSTNGLWRGESICGSFNQYRALALYAAEEMKVGIRVASHADHGLWVDGLFVGSSSSSSVGHYLYQVRLARGWNRLILKLNTTGKSRVFHAARGKITWESAQNTCRKKNGMQLCSLSEICPLGVAPREAASTPQKSFWVPVNSAENGWAQITVKRGNKTLLCHAWRKDDGRWSPAKDPHNRHLGQLAVACCGGTPAPPMWLSVIPPNRARGRVGYTYDFPPAPDRVVVKMPEGVTRSTPIVGDLQGGVPASSTKNDARYRTGGLTFVRESWSLLTRGKATALPNGSSEILVNRVACLAYSPCSLSVKGVKDGWYFSLLRTDTDESMVERFLQGEYAKIQRPSLSFSGVLPVAQKNAVVVPPLNIGSFYMIAYNPNMTGTLAATRLEYRTLSITPKEVVGTQASAFKAEGSALELGDAVLIPTGNPNSPADCGTHKCHQEFSRSTDGVAVIYSNVSFPFTQDLYGYNGSISCLCVCLSCSLPPYTAATVRVESSKVVGFPINITVTLPPAPADDIVAAIRPRMVRDGVVAQFYGRFDPRKGYAVNFTSSGTPRPDCTKPFCSVLSITEELLTCEVHVNTPLACNWTAVVSSGGKAVPFSSGSFTTLQVHPSPPSVEYVTGSCASISAWCVNDTKLTLHGNNFNPVGAEYNRVIVGDDTSDAAVLCDVLSASASTITCTLKVLQSKGEEIYPIGIETRFSEDEWGERQEAGYLVVGGGAFVGGWTEDPVHRSVWGKNSQVFVVCSFIGVVVIFAIAAIVFSRMHATSSDIDVALVEDDGMGHAGSTETEERTHEDTISRFRDSVATPPGERA
Protein: Ribosomal protein S23 (D6R9I7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEVSISTLSYLLFLGWPPSHFYLMQGSFLT
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9VR61)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Gigas, isoform A
- LD23779p
- TBC1 domain family member 7
- Mitogen-activated protein kinase ERK-A
- RINT1-like protein
- Cyclic AMP response element-binding protein B
- Syntaxin-18
- Vesicle transport protein USE1
- Centromere/kinetochore protein zw10
- Raptor, isoform B
Sequence:
MPLADSQKDLRQQPQQQQQQQHVSSTSSSNNAEQQCSSSGLGLQLRQRMQITSSGCSSLAVTPMEHTPTEDDESGGGNSGVTSSVTTVTSSQRRQQLQQVQQQSALQAALEQHHISPTADLDSARKRPTHRTLCPPPELMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSRDDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGNFHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAIPQAANVGPVELSMLAKRRAKDRANLHS
Protein: Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)] (P11172)
Organism: Homo sapiens (Human)
Function: Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP).
Interaction partners:
- Dihydropyrimidine dehydrogenase [NADP
- Dihydroorotate dehydrogenase
- Uridine phosphorylase 2
- Uridine phosphorylase 1
- Thymidine phosphorylase
- Uridine-cytidine kinase-like 1
- Uridine-cytidine kinase 1
- Uridine-cytidine kinase 2
- Uracil phosphoribosyltransferase homolog
- Ribose-phosphate pyrophosphokinase 3
Sequence:
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
Protein: Protein FAM83E (Q2M2I3)
Organism: Homo sapiens (Human)
Function: May play a role in MAPK signaling.
Interaction partners:
Sequence:
MAASQLAALEGVDSGPRVPGASPGFLYSEGQRLALEALLSKGAEAFQTCVQREELWPFLSADEVQGLAAAAEDWTVAKQEPSGMAEGATTTDVDAGSLSYWPGQSEQPAPVLRLGWPVDSAWKGITRAQLYTQPPGEGQPPLKELVRLEIQAAHKLVAVVMDVFTDPDLLLDLVDAATRRWVPVYLLLDRQQLPAFLELAQQLGVNPWNTENVDVRVVRGCSFQSRWRRQVSGTVREKFVLLDGERVISGSYSFTWSDARLHRGLVTLLTGEIVDAFSLEFRTLYAASCPLPPAPPQKPSVIGGLQRGRSPHRVSRRRSVAPASPPPPDGPLAHRLAACRVSPATPGPALSDILRSVQRARTPSGPPARPSRSMWDLSRLSQLSGSSDGDNELKKSWGSKDTPAKALMRQRGTGGGPWGEVDSRPPWGGALPLPPAHRLRYLSPARRRFGGDATFKLQEPRGVRPSDWAPRAGLGGQP
Protein: Transcription factor RAU1 (Q8S490)
Organism: Oryza sativa (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
AMSSGWEESSLMSDTNISGVKRQRDSSEPSQNGGGGGGLAHQFSLPKTSSEMAAIEKFLQFQDAVPCKIRAKRGCATHPRSIAERVRRTRISERIRKLQELVPNMDKQTNTADMLDLAVDYIKDLQKQVKGLNDSRANCTCSAKHQQYSG
Protein: Transcriptional regulator, Fur, putative (Q2FY73)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Interaction partners:
- Glutamate synthase, large subunit, putative
- Tyrosine recombinase XerD
Sequence:
MEERLNRVKQQLQQSSYKLTPQREATVRVLIENEKDHLSAEDVYLKVKDKAPEIGLATVYRTLELLAELKVVDKINFGDGVARFDLRKEGAKHFHHHLVCMECGRVDEIDEDLLPEVENRVENEFNFKILDHRLTFHGVCETCQAKGKG
Protein: Small ribosomal subunit protein eS25B (40S ribosomal protein S25-B) (S31-B) (O74172)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein eS21
- Small ribosomal subunit protein eS27
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein eS7
- Elongation factor 3
- mRNA export factor elf1
Sequence:
MAPKKKWSKGKVKDKAQHATVFDKSIIDRINKEVPAFKFISVSVLVDRMKINGSLARIAIRDLAERGVIQKVDQHSKQAIYTRAAASA
Protein: Autotaxin (EC 3.1.4.39) (EC 3.1.4.4) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2) (E-NPP 2) (Extracellular lysophospholipase D) (LysoPLD) (Q13822)
Organism: Homo sapiens (Human)
Function: Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF).
Subcellular location: Secreted {ECO:0000269|PubMed:12176993, ECO:0000269|PubMed:15769751, ECO:0000269|PubMed:1733949, ECO:0000269|PubMed:26371182, ECO:0000269|PubMed:27754931}.
Interaction partners:
- Lysophospholipase D GDPD1
- Lysophospholipase D GDPD3
- Lysophosphatidic acid receptor 1
- Lysophosphatidic acid receptor 2
- Lysophosphatidic acid receptor 3
- Lysophosphatidic acid receptor 4
- Lysophosphatidic acid receptor 6
- Lysophosphatidic acid receptor 5
Sequence:
MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYGRPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLHTYESEI
Protein: Serine/threonine-protein kinase 11-interacting protein (B4DKM2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MFGSAPQRPVAMTTAQRDSLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWPVGSTPETSGGPDLSDSLSSGGVVTQPLLCVSGSSSHSAA
Protein: Ras-related protein Rab-4B (EC 3.6.5.2) (Q91ZR1)
Organism: Mus musculus (Mouse)
Function: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Protein transport (By similarity). Probably involved in vesicular traffic (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P61018}; Lipid-anchor {ECO:0000250|UniProtKB:P61018}; Cytoplasmic side {ECO:0000250|UniProtKB:P61018}. Early endosome membrane {ECO:0000250|UniProtKB:P61018}; Lipid-anchor {ECO:0000250|UniProtKB:P61018}; Cytoplasmic side {ECO:0000250|UniProtKB:P61018}.
Interaction partners:
- Rabenosyn-5
- Rab GTPase-binding effector protein 1
- A-kinase anchor protein 10, mitochondrial
- GRIP1-associated protein 1
- Rab11 family-interacting protein 1
- ADP-ribosylation factor 6
- Ras-related protein Rab-7a
- Early endosome antigen 1
- Rab5 GDP/GTP exchange factor
- RUN and FYVE domain-containing protein 1
Sequence:
MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDISLRQLRQPRSAQAVAPQPCGC
Protein: Uncharacterized protein (Q38D92)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSAPQPLSESFTHLVGDCELVFKHPVSYEPPLYLFPELLGKVPEGTAPVAVGDAVSDALVVESSFLNIAELFHLPTEDLRKGVGSAKRGAAAGDITPPQDEAEKKGPKVTLASLLASNRLQSIGLTAEVLQRGKFSSGAVIDELLKLKQRVGLNDDEAKVIMSNHFINLLAWSTAVEINSHQLPAKRGRESDNNGDAYEREEIVAGCNEKKRDRPCSDDGAGEIDIQTLQPSEDPWSNDVDLHPGTFVAAAEKDVEKRVELIENLTKLYRRPWRTLQSKGIQTDRLVPGVINETAPYVDLMKLPGAYLDGVRELGWKPAVHSNSEERCRWILQVTSTSVSDSQTISVRGRVMHFGRTAGVVSSVSNGITNIHVGLVSLTQHPEFVSPHHFSLFLLPNKSSSSGTGEDSKRREDGGTEVQENEEVSQFLWLVNYGRNGVRVQGKQWTLGNMLRLEVGDVFYPTHDIRVVVADGLAAVGLPEIRKKTDEEGEAEAEVAVKPEPVVSLDG
Protein: Uncharacterized protein YnbC (P76092)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YnbD
- Inner membrane protein YnbA
- Uncharacterized protein YnbB
- NADH-quinone oxidoreductase subunit C/D
- Uncharacterized protein YdbD
- NADH-quinone oxidoreductase subunit F
- NADH-quinone oxidoreductase subunit G
- NADH-quinone oxidoreductase subunit E
- Transposase InsD for insertion element IS2A
Sequence:
MENSRIPGEHFFTTSDNTALFYRHWPALQPGAKKVIVLFHRGHEHSGRLQHLVDELAMPDTAFYAWDARGHGKSSGPRGYSPSLARSVRDVDEFVRFAASDSQVGLEEVVVIAQSVGAVLVATWIHDYAPAIRGLVLASPAFKVKLYVPLARPALALWHRLRGLFFINSYVKGRYLTHDRQRGASFNNDPLITRAIAVNILLDLYKTSERIIRDAAAITLPTQLLISGDDYVVHRQPQIDFYQRLRSPLKELHLLPGFYHDTLGEENRALAFEKMQSFISRLYANKSQKFDYQHEDCTGPSADRWRLLSGGPVPLSPVDLAYRFMRKAMKLFGTHSSGLHLGMSTGFDSGSSLDYVYQNQPQGSNAFGRLVDKIYLNSVGWRGIRQRKTHLQILIKQAVADLHAKGLAVRVVDIAAGHGRYVLDALANEPAVSDILLRDYSELNVAQGQEMIAQRGMSGRVRFEQGDAFNPEELSALTPRPTLAIVSGLYELFPENEQVKNSLAGLANAIEPGGILIYTGQPWHPQLEMIAGVLTSHKDGKPWVMRVRSQGEMDSLVRDAGFDKCTQRIDEWGIFTVSMAVRRDN