wanglab/gogpt-training-data huggingface dataset:
Protein: Tubby protein homolog (O88808)
Organism: Rattus norvegicus (Rat)
Function: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19695251}. Nucleus {ECO:0000250}. Secreted {ECO:0000269|PubMed:19695251}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MTSKPHSDWIPYSVLDDEGSNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQPGATRPPAPASAKKTKGAAASGGQGGAPRKEKKGKHKGTSGPATLAEDKSEAQGPVQILTVGQSDHAKDAGETAAGGGAQPSGQDLRATMQRKGISSSMSFDEEEDEDENSSSSSQLNSNTRPSSATSRKSTREAASAPSPAAPEPPVDIEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVCIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
Protein: MET transcriptional regulator MACC1 (Metastasis-associated in colon cancer protein 1) (E7FG38)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MAAAKIKSNSHPANLLRSRSEGTLIDIDENVTINNNNLHGGCGYEIGKTSEWPVIQKEIENPKQTTNPFWNQLGRSNPFLNEIVHTSNYDSGVSMMKEDPASLFDSINEDSLSTSSDETNFAHLLAPRQNNLNRSGRWRSASDILESLEKKEDKRAVKLSSKESFLNPDFEWLKNDREAYKMAWLSHRQLTRSCLDLSLMKQSPGWAQTQATDIQIFCKIDHNGGSVQLPESDITAHIPHGHVPPGEVQDIALKVHLDPPPGINNNYTTTLSPLLEVKLSNSNISGGISVEMRMAAKVKNDPTSHVLTSFMGLVSQRKEGPYQKIKDCYIYNDMLQMKLFDLKPHMYVITAAEATVLESPAVSVWDYLDRQITVAVYGPKHIHPSLKVVLVIMSHNNIAPRLPFSDIQRGNRNLPPVVLELWGRHQFNPQGLKDLHIVSRVLDLNFEVKPEDQNKEIKQKQLEDGKVHHLPLDLVKVGGGEMSAFKLSIEVKDSNSLTLGDFYVASPEAAPLRSEKYNHRRVDWQKEAIRSSPIPEESIPEILSQKFQDRPVDLHWYGVAMKSVLRQPRVEYLLEYFKGDTIALLSKETVRSVGHMKVKEWYIGFLRGRVGLVHCKNLKIITKDQVIDFTGIHLTTPVLLDNMTVPFKKLTYMYSAIQTLVTEHVKCWRNFAEALGYSEVSVDAISRRHAETEAEKVACVLEKLKEDCHAEKNKKKFQHELIIGLLKMDAQGLVAHLIQDIVILSTAVELGVRWRELAERLGKISSAQIAVYEAPHKGKNGEVSTQSMWKPAYDFLFAWSKRYGDSYRDMIQDLHLALDKMKSPVTKQWRQITGALITINSMEVLRTYAFNRG
Protein: Probable oxidoreductase (O53398)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Hydroxyacyl-CoA dehydrogenase ChsB1
Sequence:
MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGALRRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVGPVDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVGRKAFARFAGYSSAMHAIAGFSDALRQELRGSGIAVSVIHPALTQTPLLANVDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQPRLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAKAQAAQPERGYSSAR
Protein: Laccase-15 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 15) (Diphenol oxidase 15) (Protein TRANSPARENT TESTA 10) (Urishiol oxidase 15) (Q84J37)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lignin degradation and detoxification of lignin-derived products (By similarity). Involved in lignin synthesis in seed coats, in seed coat permeability, in seed germination, and in root elongation. Required for the seed coat (testa) brown pigmentation by mediating the polymerization of proanthocyanidin (tannin) from its monomer precursor epicatechin. Slightly promotes seed dormancy.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Phenylalanine ammonia-lyase 1
- Phenylalanine ammonia-lyase 4
- Phenylalanine ammonia-lyase 2
- Cinnamoyl-CoA reductase 1
- Phenylalanine ammonia-lyase 3
- Cinnamoyl-CoA reductase 2
- Anthocyanidin reductase
- Probable caffeoyl-CoA O-methyltransferase At4g26220
- Dihydroflavonol 4-reductase
- Protein DETOXIFICATION 41
Sequence:
MSHSFFNLFLISLFLYNNCIAHHYTFTVREVPYTKLCSTKAILTVNSQFPGPIIKVHKGDTIYVNVQNRASENITMHWHGVEQPRNPWSDGPEYITQCPIRPGSDFLYKVIFSIEDTTVWWHAHSSWTRATVHGLIFVYPRPPQILPFPKADHEVPIILGEWWKRDVREVVEEFVRTGGAPNVSDALTINGHPGFLYPCSKSDTFHLTVEKGKTYRIRMVNAAMNLPLFFAIANHSLTVVSADGHYIKPIKATYITISPGETLDMLLHADQDPERTYYMAARAYQSGNIDFNNSTTIGILSYTSSCKAKTSSFSGYYPTLPFYNDTSAAFGFFTKIKCLFSGQVPVQISRRIITTVSINLRMCPQNSCEGPNGSRLAASMNNISFVTPSHVDILKAYYYHIKGVYGTRFPEFPPLIFNFTAENQPLFLETPRLATEVKVIEFGQVVELVIQGTSLVGGGLDHPMHLHGFSFYVVGVGFGNYNISEEDPSSRYNLYDPPYKNTMTVPRNGWIAIRFVADNPGVWFMHCHLDRHQTWGMNVVFIVKNGREPNQQILPPPDDLPPCYE
Protein: Probable metabotropic glutamate receptor mgl-1 (Q09630)
Organism: Caenorhabditis elegans
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-2
- NMDA-type ionotropic glutamate receptor NMR-2
Sequence:
MDKKWSLEQRWLHLLNQQFLDCLNHLFNHYRRLSTFQKPPSIIRHMFSVLALAIQILANVNVVAQTTEAVDLAPPPKVRQIRIPGDILIGGVFPVHSKSLNGDEPCGEIAETRGVHRVEAMLYALDQINSQNDFLRGYKLGALILDSCSNPAYALNQSLDFVRDMIGSSEASDYVCLDGSDPNLKKQSQKKNVAAVVGGSYSSVSVQLANLLRLFRIAQVSPASTNADLSDKNRFEYFARTVPSDDYQAMAMVEIAVKFKWSYVSLVYSADEYGELGADAFKKEARKKGICIALEERIQNKKESFTESINNLVQKLQPEKNVGATVVVLFVGTEYIPDILRYTAERMKLTSGAKKRIIWLASESWDRNNDKYTAGDNRLAAQGAIVLMLASQKVPSFEEYFMSLHPGTEAFERNKWLRELWQVKYKCEFDTPPGSTASRCEDIKQSTEGFNADDKVQFVIDAVYAIAHGLQSMKQAICPDDAIENHWISRYSKQPEICHAMQNIDGSDFYQNYLLKVNFTGKTISIFSSFRLSPFSDIVGKRFRFSPQGDGPASYTILTYKPKSMDKKRRMTDDESSPSDYVEIGHWSENNLTIYEKNLWWDPDHTPVSVCSLPCKIGFRKQLIKDEQCCWACSKCEDYEYLINETHCVGCEQGWWPTKDRKGCFDLSLSQLKYMRWRSMYSLVPTILAVFGIIATLFVIVVYVIYNETPVVKASGRELSYILLISMIMCYCMTFVLLSKPSAIVCAIKRTGIGFAFSCLYSAMFVKTNRIFRIFSTRSAQRPRFISPISQVVMTAMLAGVQLIGSLIWLSVVPPGWRHHYPTRDQVVLTCNVPDHHFLYSLAYDGFLIVLCTTYAVKTRKVPENFNETKFIGFSMYTTCVVWLSWIFFFFGTGSDFQIQTSSLCISISMSANVALACIFSPKLWIILFEKHKNVRKQEGESMLNKSSRSLGNCSSRLCANSIDEPNQYTALLTDSTRRRSSRKTSQPTSTSSAHDTFL
Protein: WPP domain-interacting tail-anchored protein 2 (A8MQR0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with WIT1, required for the nuclear envelope docking of RANGAP proteins in root tips. Plays a role in nuclear shape determination. As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Myosin-15
- SUN domain-containing protein 3
- SUN domain-containing protein 1
- Putative F-box/FBD/LRR-repeat protein At3g49480
- Protein KAKU4
- Protein SINE1
- Protein CROWDED NUCLEI 1
- SUN domain-containing protein 4
- WPP domain-containing protein 2
- Protein CROWDED NUCLEI 4
Sequence:
MEEIIREDYFEALSSRNEEEQEMLRMLTKLEIDSAYTSEKLMNLHVLLMHLLAWDNDLEGMGTLDSSPASFEKALTFDLLCGILESEVKEVDEVLDVLEAQIVDTSYKISSCKHGNYIVIEGKLGESAESLKQSRGQVSEITLQLAQLRRTLHYIRNGTSENEESVELRQKYALKPSDLRHKNALRMLEKSLSRELELEKKLMEFQQNEEQLKLKLHYTEEVSSRMEEASEFIWGRFLEADNSSEVLTGISKELVGRLQILQFSLNGSAQRESELKSKLEDCTVQLEAKDLLVQKLEGTISENSEIVSEVLTLREYVKSAEQKLKNTDLELKSVNASKQEILVHLAEMENANESVKENLFEAESRAESGEAKIKELDAANLELTEELNFLKDADDKKTKKVNSLEKQVRELEVQVQNSKVSSEANQEQQNMLYSAIWDMETLIEDLKSKASKAESRTETVEEQCIVLSTTNSELNKDVSFLRQKAKSLEAMLDLANNEKERYAQEITTRNKVLMDMMLQLSSERERIQEQLYSLAKENKILRVNQCSNTYQRNGSYAGDKELSFHADGHEIEALAESLQEDERTREEPEKQSVSEKSSEIRRAIKLKHILVVALVFVLFCSFFGVTY
Protein: Forkhead box protein D4-like 1 (FOXD4-like 1) (Q9NU39)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Interaction partners:
- Forkhead box protein D4
Sequence:
MNLPRAERPRSTPQRSLRDSDGEDGKIDVLGEEEDEDEVEDEEEEASQKFLEQSLQPGLQVARWGGVALPREHIEGGGPSDPSEFGTEFRAPPRSAAASEDARQPAKPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPREPGHPGKGTYWSLDPASQDMFDNGSFLRRRKRFKRHQLTPGAHLPHPFPLPAAHAALHNPRPGPLLGAPALPQPVPGAYPNTAPGRRPYALLHPHPPRYLLLSAPAYAGAPKKAEGADLATPGTLPVLQPSLGPQPWEEGKGLASPPGGGCISFSIESIMQGVRGAGTGAAQSLSPTAWSYCPLLQRPSSLSDNFAATAAASGGGLRQRLRSHQGRGAGRAPVGRVGAAAVSGGGRGL
Protein: RNA-binding motif, single-stranded-interacting protein 3 (Q8BWL5)
Organism: Mus musculus (Mouse)
Function: Binds poly(A) and poly(U) oligoribonucleotides.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MGKRLDQPQMYPQYTYYCPQYLQTKQSYAPAPHPMAPPSPSTNSSSNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPLLCKFADGGQKKRQGQSKHTQNGRPWPREGEAGMALTYDPTAALQNGFYSSPYSLATNRMIPQTSITPFIAASPVSTYQVQSTSWTPHLPYIMQPTGAVITPAVDHPMSMQPTNIVGPLTQQMNHLSLGTAGTIQSQDRIMVLHQLLCQYMTAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQTVAPSSQDSSGQQQQLAVDTPSEHAPAYSFQQSKP
Protein: Ribosomal protein L22-like 1 (EC 3.6.5.3) (Zgc:136591) (Q0VFW0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- FAU ubiquitin-like and ribosomal protein S30 fusion a ubiquitously expressed
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL5
- Ribosomal protein L4
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL30
- Ribosomal protein L26
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein eL27
Sequence:
MAPKRQTVVRKNKKGACWKFTLDCTHPVEDGILDSANFETFLKEKVKVNGKTGNLGNVVQIVRQKNKINVTSEKQFSKRYLKYLTKKYLKKNNLRDWLRVVASDKESYELRYFQISQDDEESDADE
Protein: Serine/threonine-protein kinase prp4 (EC 2.7.11.1) (Q07538)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in pre-mRNA splicing and is essential for growth. Phosphorylates srp1.
Interaction partners:
- Pre-mRNA-splicing factor prp1
- Pre-mRNA-splicing factor cwf10
- Probable U2 small nuclear ribonucleoprotein B''
- Pre-mRNA-splicing factor spp42
- Pre-mRNA-processing factor 31
- U2 snRNP component prp10
- Pre-mRNA-splicing factor brr2
- U4/U6.U5 tri-snRNP-associated protein snu66
- Uncharacterized WD repeat-containing protein C227.12
- Pre-mRNA-splicing factor prp12
Sequence:
MSDDRFAEDEIIQQRRKRRLEILKKYQQTGNGHSDLSIPEKKLKEDVDQVSTTKPIEAVPKMKTNASKIEINKEGSNSNTKLDVTNSTTSDSPSIKSSVQIEDTEDDMFADSPSPSVKRQNTGKGISTLTRSFADMQDNWDDIEGYYKVVLMEELDSRYIVQSNLGKGMFSTVVSALDRNRNQTFAIKIIRNNEVMYKEGLKEVSILERLQAADREGKQHIIHYERHFMHKNHLCMVFEMLSLNLRDILKKFGRNVGLSIKAVRLYAYQMFMALDLLKQCNVIHSDIKPDNMLVNEKRNILKICDLGSASDASENEITPYLVSRFYRAPEIILGFPYSCPIDTWSVGCSLYELYTGQILFPGRTNNQMLRYMMECKGKFSHKMLKRSQFLNDHFDADFNFIQIDHDPITNQETRKPVKFSKPTKDIRSRLKEVPTSTDEEFIIRQELMDLLEKCLELNPEKRVPPEVALKHPFFIKK
Protein: Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) (Q58CQ2)
Organism: Bos taurus (Bovine)
Function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O15143}. Nucleus {ECO:0000250|UniProtKB:O15143}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 5-like protein
- Actin nucleation-promoting factor WAS
- Actin nucleation-promoting factor WASL
- Actin, cytoplasmic 2
Sequence:
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGIDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAVTFITESSLVAAGHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRSLESALKDLKIV
Protein: Dual specificity protein phosphatase, putative (Q38C79)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQELIAVRVKDGIFVGNAVAAHDREFISLNKITHVVNCAGGELADLFADDGVKYLTFPWKDPTGSVCTAVMFDSADENVKRTVRFIDEALEAGDCVLVHSQLGMSRSPALVAAYLIVKYGWKLESAISFLEMAHKDMSIKPHFLRQLRMFAKRNTIEHDIFDVDVDDSSFGLDNVQWMLRNTLLNGLTSASQRQNELYKLCSSKVDVGQPVKTSDVRVTTTRMKKAKRLVFVDTKQGSDVEPRSGTPVVTVQPLRQSEPGNHFLGYHGSIALEGRRRSNSIMRHSVSPCGRSVESDPSTNPHGRQELTLRFESKSGRSCSAFDGATSSQAARTASGYSTIDGASHVGEYHTHLPSPDTIHAPARSPFATLTSGHKYRKGSPLPSVVYNSSPMRSVQRPSSALVSEGRGAQLRTSSYTRPTGFSRSGVARSGSPCSVSSHSSAFLATSTRLSSYRNIAPHRSQPSSNVQPAWSAGKTALSPSRVHRSLLRSSPLNNRPGSPVERPSSTPRRVSSPTSGSADACSSRTVCGTNSGSKGGGVGLLRRQIPAAIPSSRS
Protein: THO complex subunit 3 (TEX1 homolog) (AtTEX1) (Q9FKT5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export. Contributes to the integrity of the endogenous trans-acting small interfering RNA (ta-siRNA) pathway. May process or transport a long RNA molecule so that it can be a template for secondary siRNA production. May participate in the trafficking of siRNA precursors to the ARGONAUTE catalytic center. Required for the generation of functional messenger ribonucleoproteins (mRNPs).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- THO complex subunit 7B
- THO complex subunit 7A
- THO complex subunit 2
- THO complex subunit 5B
- THO complex subunit 1
- THO complex subunit 6
- THO complex subunit 5A
- THO complex subunit 4B
- THO complex subunit 4D
- THO complex subunit 4A
Sequence:
MEETTIPFKSLHSREYQGHKKKVHSVAWNSNGTKLASGSVDQTARIWNIEPHGHSKAKDLELKGHTDSVDQLCWDPKHSDLVATASGDKSVRLWDARSGKCTQQVELSGENINITYKPDGTHVAVGNRDDELTILDVRKFKPLHRRKFNYEVNEIAWNMPGDFFFLTTGLGTVEVLSYPSLKPLDTLTAHTAGCYCIAIDPKGRYFAVGSADSLVSLWDISDMLCLRTFTKLEWPVRTISFNYSGEYIASASEDLFIDIANVQTGRTVHQIPCRAAMNSVEWNPKYNLLAYAGDDKNPKYNTDEGVFRIFGFESS
Protein: CST complex subunit STN1 (Alpha-accessory factor of 44 kDa) (AAF-44) (AAF44) (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog) (Q8K2X3)
Organism: Mus musculus (Mouse)
Function: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:19119139, ECO:0000269|PubMed:19854130}. Chromosome, telomere {ECO:0000269|PubMed:19854130}.
Interaction partners:
- CST complex subunit CTC1
- CST complex subunit TEN1
- Protection of telomeres protein 1
- DNA polymerase alpha catalytic subunit
- Protection of telomeres protein 1
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 13
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 25
- Mediator of RNA polymerase II transcription subunit 16
Sequence:
MPQPCLLMECESSPREEEIPPLFWGLDPVFLAFAKLYIKDILEMKESQQVPGTYFYNGHPIRRVDIMGAVISVKERETFYSYGVDDATGVINCVCWKKLSNAESSSDPAILSTARELSMTSQLKKLQETIEQKTRIGIGDIIRVRGSVRMFREEREICANIYYKVDDPVWNMQIARMLELPKLYQKVYDQPFRNPALQEEEALNNKDNLDLAGLTSLLSEKIKEFLQEKKMQSFYQQELETVESLQSLASRPVTHSTGSDQVELKDSGTSGVAQRVFKNALQLLQEKGLVFQRDSGSDKLYYVTTKDKDLQQKIYHIIKEDCQKPNHMEKGCHLLHILNCVHLNLRWDLSKAVLQRVLELLEDQSDIVSTADHYYAAF
Protein: Nuclear receptor subfamily 2 group F member 1 (Ovalbumin upstream promoter-transcription factor I) (F1DAL9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MAMVVSSWRDPQDDVAGGNPGGPNPAAQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS
Protein: GLO-3 (Gut granule LOss) (G5EBW0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MFGYVVVNEQNSIVFLDGNEEFKTIFQSLIQSEITSRKSDLDSASSGVGSSTCTEEQESSLDHFKKPNVVFNSSEISHILLPLILLYRSTSEKTKDPITEMSSQFGTISISKFYHNYLVLVFANDDRKRIEVSQTIEHTIATLFGPLIAFCHTDLTTVKKPKEHLACALTRKLSYSPKSFIDIRRKLFYFDKIAKLKDTFHKISSQLNVFVDNNRCLLLSKGDIIATYNSVEGNDDVLKGLNTNDLLNIVSNTSKCDANTKIEQFWLRSTTGLIPYYVNVISATVFKNMTLVCLVESSENTLIRYLYLFSKQLDQLRISQDLNRDLKEVRKTINDIHILLLSRKPLPDTYCAAFMRNPLRASSFFKSIWNQIETEVLQINRHSATPTQKPRSESRFSISSWRSALSTMSLSSSVFTRITMDDKTMTQKMDILLSYGKKQINSLIQELCSISIANAKLSTLPLFNQCLEKTVKPNSVKAVDSLGIGSKEQEDKLEKFLKPSEFFLEMYAYRIQFDDLKQEITYISDEYKENVNWIRQLKSANRFSCDYLRNSGEKFMIFHFNLPNLNQKSTECRSNIRMTAVFPEYMNKNLAEKQTNKLLECVLKQLK
Protein: Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1 homolog) (A0A1L8ER70)
Organism: Xenopus laevis (African clawed frog)
Function: Plays an important role in ciliogenesis. Required for apical targeting/anchoring of centrioles at the plasma membrane.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:19656802}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19656802}. Note=Localized to basal bodies in multiciliated cells (PubMed:19656802). {ECO:0000269|PubMed:19656802}.
Interaction partners:
- C2 domain-containing protein 3
- sodium channel and Clathrin linker 1
- sodium channel and Clathrin linker 1
- Fas-binding factor 1 homolog isoform X6
Sequence:
MSLRDRQFREEPSENALPLDRNHFRPSTEYDQSYEPLEASGQSGDSDLVSEYAQGNMSVTVSEEELRHELSLLGFSYVPRQRLLEFKKDLERLMNRGSAAASPETSRLENESLDDSTNTPPPLPIETSAWHQTSAWPTTTSTSSKEWDNQQRNQDSYTKHTVSLGGNVQATKKAPQITRKVLRRKSDGQTHVSDESFLYSETETEEEDTGSSIVDFRSESSGRSSASCAKSFIRPPLYSLLDQYRQRSDPVGRYQEYKQKWDALQGALERNRKELRWGIREQMMSAPPQPAARSVLLPNTYVIPTDKKRYALRWAVRRDLVNGVMPRGSYS
Protein: KLF transcription factor 4 (Kruppel-like factor 4 (Gut)) (Q923V7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Catenin beta-1
- Homeobox protein NANOG
- Myc proto-oncogene protein
- POU domain protein
- SRY-box transcription factor 2
- Protein lin-28 homolog A
- Cellular tumor antigen p53
- Myocardin
- Zinc finger protein 750
- Steroid hormone receptor ERR2
Sequence:
MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRPAGAPTNRWREELSHMKRLPPLPGRPYDLAATVATDLESGGAGAACSSNNPALPRRETEEFNDLLDLDFILSNSLSHQESVAATVTTSASASSSSSPASSGPASAPSTCSFSYPIRAGGDPGVAAGNTGGGLLYSRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSTPGSEYTSPSVISVSKGSPDGSHPVVVAPYSGGPPRMCPKIKQEAVPSCTVSRSLEAHLSAGPQLSNGHRPNTHDFPLGRQLPTRTTPTLSPEELLNSRDCHPGLPLPPGFHPHPGPSYPPFLPDQMQSQVPSLHYQELMPPGSCLPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF
Protein: Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (P28758)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P00445}.
Interaction partners:
- Superoxide dismutase, mitochondrial
- Small ribosomal subunit protein mS43
- Catalase
- Glutathione-independent glyoxalase DJ-1
- Glutathione peroxidase-like peroxiredoxin gpx1
- Glutamate--cysteine ligase
- Glutathione reductase
- Peroxiredoxin tpx1
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
Sequence:
MVRAVAVLRGDSKVSGVVTFEQVDQNSQVSVIVDLVGNDANAKRGFHIHQFGDNTNGCTSAGPHFNPEGKTHGDRTAAVRHVGDLGNLESDAQGNIKTTFSDSVISLFGANSIIGRTIVIHAGEDDLGKGTSEESLKTGNAGARNACGVIGIAV
Protein: Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111) (Q15223)
Organism: Homo sapiens (Human)
Function: Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11356977, ECO:0000269|PubMed:21325282, ECO:0000269|PubMed:34587223, ECO:0000269|PubMed:38857290}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000269|PubMed:10225955}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9JKF6}; Single-pass type I membrane protein. Note=In the auditory epithelium, specificaly localizes to the apical side of the lateral membranes of hair cells. {ECO:0000250|UniProtKB:Q9JKF6}.; SUBCELLULAR LOCATION: [Isoform Alpha]: Cell membrane {ECO:0000269|PubMed:11356977}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform Delta]: Cell membrane {ECO:0000269|PubMed:11356977}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform Gamma]: Secreted {ECO:0000269|PubMed:11356977}.
Interaction partners:
- Afadin
- Nectin-3
- Atypical chemokine receptor 1
- Cadherin-17
- T-cell surface protein tactile
- CD226 antigen
- Nectin-4
- T-cell immunoreceptor with Ig and ITIM domains
- Partitioning defective 3 homolog
- Cell adhesion molecule 3
Sequence:
MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV