wanglab/gogpt-training-data huggingface dataset:
Protein: Type 3 secretion system translocon protein SctE (T3SS translocon protein SctE) (62 kDa antigen) (Invasin IpaB) (P18011)
Organism: Shigella flexneri
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Forms a pore with IpaC, which is inserted into the host cell membrane through the Mxi/Spa apparatus, during cell contact. This pore probably allows the translocation of IpaA. IpaB has also been found to be necessary and sufficient to activate macrophage apoptosis by binding to interleukin-1 beta converting enzyme (ICE). Has also been shown to be important, along with IpaD, to block or regulate secretion through the Mxi/Spa translocon in the presence or absence of the secretion signal, respectively. Through interaction with host human MAD2L2, constitutively activates the anaphase-promoting complex APC and induces a cell cycle arrest to prevent epithelial renewal in order to promote bacterial colonization.
Subcellular location: Secreted {ECO:0000269|PubMed:10545510, ECO:0000269|PubMed:17719540, ECO:0000269|PubMed:7954817, ECO:0000269|PubMed:9009343}. Host membrane {ECO:0000269|PubMed:10545510, ECO:0000269|PubMed:34809452}; Multi-pass membrane protein {ECO:0000269|PubMed:34809452}. Host cell {ECO:0000269|PubMed:9009343}. Host nucleus {ECO:0000305|PubMed:17719540}. Note=Secreted via the type III secretion system (T3SS) (PubMed:10545510). Localizes at the surface of needle tips via IpaD/SctA (PubMed:17367391). IpaB/SctE and IpaC/SctB form a multimeric integral membrane complex in eukaryotic cell membranes (PubMed:10545510, PubMed:17367391). Also secreted into the cytoplasm of the infected macrophage after the escape of bacteria from phagosome, where it colocalizes with ICE (PubMed:8670890, PubMed:9009343). May localize to host cell nucleus during G2/M phase of the host cell cycle (PubMed:17719540). {ECO:0000269|PubMed:10545510, ECO:0000269|PubMed:17367391, ECO:0000269|PubMed:17719540, ECO:0000269|PubMed:8670890, ECO:0000269|PubMed:9009343}.
Interaction partners:
Sequence:
MHNVSTTTTGFPLAKILTSTELGDNTIQAANDAANKLFSLTIADLTANQNINTTNAHSTSNILIPELKAPKSLNASSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSETEGLTRDYEKQINKLKNADSKIKDLENKINQIQTRLSELDPESPEKKKLSREEIQLTIKKDAAVKDRTLIEQKTLSIHSKLTDKSMQLEKEIDSFSAFSNTASAEQLSTQQKSLTGLASVTQLMATFIQLVGKNNEESLKNDLALFQSLQESRKTEMERKSDEYAAEVRKAEELNRVMGCVGKILGALLTIVSVVAAAFSGGASLALAAVGLALMVTDAIVQAATGNSFMEQALNPIMKAVIEPLIKLLSDAFTKMLEGLGVDSKKAKMIGSILGAIAGALVLVAAVVLVATVGKQAAAKLAENIGKIIGKTLTDLIPKFLKNFSSQLDDLITNAVARLNKFLGAAGDEVISKQIISTHLNQAVLLGESVNSATQAGGSVASAVFQNSASTNLADLTLSKYQVEQLSKYISEAIEKFGQLQEVIADLLASMSNSQANRTDVAKAILQQTTA
Protein: Zona pellucida sperm-binding protein 3 receptor (Sperm fertilization protein 56) (sp56) (Q7TSY4)
Organism: Rattus norvegicus (Rat)
Function: Binds to ZP3 glycoprotein in egg zona pellucida. Probably involved in interactions between sperm acrosome and egg zona pellucida during and immediately following the acrosome reaction (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome lumen {ECO:0000269|PubMed:12737520}. Note=Sperm acrosomal matrix.
Interaction partners:
- Sperm acrosome associated 1
- Zona pellucida sperm-binding protein 1
- Izumo sperm-egg fusion protein 1
- ADAM metallopeptidase domain 3A.
- Zona pellucida sperm-binding protein 2
- Zona pellucida sperm-binding protein 3
- Alpha-mannosidase
- Parkinson disease protein 7 homolog
- Zona pellucida-binding protein 2
Sequence:
MTAWSLHELWKTSHSTLFQVTLATVLMAPVLGDCGPPPSLPFASPISQLDEVSFPPGAVLKYTCHHGFKRTNSSHITCDENGSWVYTTFCARKRCKNPGELVNGKIEILSDLLVGLNIEFSCSEGYLLIGSATSRCEVQGKGVNWSDSLPECVIATCEPPPVINNGKHSGREEDLYTYGSMVIYSCDPSYTLFGNASIVCTVVNKTVGVWSPHPPACEKIVCHQPQIPKGELVPGFRHFHTYKDALEIRCKKGFALRGNSVIHCEANGEWFPSVPTCEPNGCIDIPDISYASWDGNRFPLENTAVFEIGTKLKYRCKPGYRANVHDVQIVTCQENLTWSSPSGCERVCCPTPNMEKIKIVSERRDFTGTCVYAYGDYVFYICSEGTYPMTTDGRSSCQADGKWDPAIPSCEADPSLQNHFALTFPNISETNVTNRTYLLENENATESFIKAVCPKPEIINGNLSVEKEIYAEMENITIQCDSGYDLVGSSNIICLENRTWYPDIPFCIMEGPEDCEIVNKGRQLLQCLSSPEDVQRALEVYKLSLEIERLEQQREKRTSVHRKAHYTKVDGPFRPFS
Protein: p44-16 outer membrane protein (Q2GIL3)
Organism: Anaplasma phagocytophilum (strain HZ)
Interaction partners:
Sequence:
MMSMAIVMAGNDVRAHDDVSALETGGAGYFYVGLDYSPAFSKIRDFSIRESNGETKAVYPYLKDGKSVKLESHKFDWNTPDPRIGFKDNMLVAMEGSVGYGIGGARVELEIGYERFKTKGIRDSGSKEDEADTVYLLAKELAYDVVTGQTDNLAAALAKTSGKDIAQFANAVKITNSTIDGKVCSGKHAALVTGKGKTYHEKPGTTEDNSAQCSGLGDGSAGADQKFLSKFVSAVGLSENKNWPTGQAGKSTGGPEVGAPNSNANAVAKDLVALNRDEKTIVAGLLTKTIEGGEVVEIRAVSSTSVMVNACYDLLSEGLGVVPYACVGLGGNFVGVVDGHITPKLAYRLKAGLSYQLSPEISAFAGGFYHRVVGDGVYDDLPAQRLVDDTSPAGRTKDTAIANGFYHRVVGDDVYESRGIKIVGVQHHA
Protein: Myotubularin (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Q13496)
Organism: Homo sapiens (Human)
Function: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12847286}. Cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12847286}. Cell projection, filopodium {ECO:0000269|PubMed:12118066}. Cell projection, ruffle {ECO:0000269|PubMed:12118066}. Late endosome {ECO:0000269|PubMed:14722070}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q9Z2C5}. Note=Localizes as a dense cytoplasmic network (PubMed:11001925). Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles (PubMed:12118066). Predominantly located in the cytoplasm following interaction with MTMR12 (PubMed:12847286). Recruited to the late endosome following EGF stimulation (PubMed:14722070). In skeletal muscles, co-localizes with MTMR12 in the sarcomere (By similarity). {ECO:0000250|UniProtKB:Q9Z2C5, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12118066, ECO:0000269|PubMed:12847286, ECO:0000269|PubMed:14722070}.
Interaction partners:
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Polyphosphoinositide phosphatase
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14
- Myotubularin-related protein 12
- Inositol polyphosphate-4-phosphatase type I A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
- Inositol polyphosphate 4-phosphatase type II
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Dynamin-2
Sequence:
MASASTSKYNSHSLENESIKRTSRDGVNRDLTEAVPRLPGETLITDKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAKLSDPPTSPSSPSQMMPHVQTHF
Protein: NAD-dependent protein deacetylase hst2 (EC 2.3.1.286) (Homologous to sir2 protein 2) (Regulatory protein SIR2 homolog 2) (Q9USN7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000305}.
Interaction partners:
- NAD-dependent protein deacetylase hst4
- NAD-dependent histone deacetylase sir2
- Putative glutamine-dependent NAD
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase
- Uncharacterized kinase C3H5.11
- Uncharacterized kinase C24B10.02c
- NAD-capped RNA hydrolase
- Putative purine nucleoside phosphorylase
- Putative nicotinamide mononucleotide adenylyltransferase
- Histone deacetylase clr3
Sequence:
MVKNTVKHVDSSKHLEKVASLIKEGKVKKICVMVGAGISTAAGIPDFRSPETGIYNNLQRFNLPYAEAVFDLSYFRKNPRPFYELAHELMPEKYRPTYTHYFIRLLHDKRLLQKCYTQNIDTLERLAGVPDKALIEAHGSFQYSRCIECYEMAETEYVRACIMQKQVPKCNSCKGLIKPMIVFYGEGLPMRFFEHMEKDTKVCDMALVIGTSLLVHPFADLPEIVPNKCQRVLINREPAGDFGERKKDIMILGDCDSQVRALCKLLGWSDELEKLIDTSVETLTEEISLLSVDSTIEKNASEQKKDDNSVNPFTKIEEKKKDEVTLLVSDDE
Protein: Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (A0A494C0U1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
ATEEPFPFHGLLPKKETGAASFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKPKIVDIIDTTGSGDVNTATEVEPKDGEIVGLSGRVLKIPASWTNPSGKYHIGIKNGYDFYPKALKERIQKERKEKIWDPVHRVALAEACRKQEEFDVANNGSSQANKLIKEELQSQVELLNSFEKKYSDPGPVYDCLVWHDGEVWRACIDSNEDGDLSKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNIIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALILSGLKANNIDYTVHSVRRALENTAVKADNIEVFAQGHGIIQVDKAYDYLVQNTSFANKLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKISLQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFIEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLTEAFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDLERLKDLPFIVSHRLSNTLSLDIHENHSFALLGKKKSSNLTLPPKYNQPFFVTSLPDDKIPKGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEEFTEALRDLKIQWMTKLDSSDIYNELKETYPNYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHTQAQDGAISTDAEGKEEEGESPLDSLAETFWETTKWTDLFDNKVLTFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF
Protein: Type IV pilus biogenesis factor PilY1 homolog PD_1611 (Q87B49)
Organism: Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Function: One of the three PilY1 homologs of X.fastidiosa, which are involved in bacterial twitching motility as component of the filamentous type IV pili (T4P). The twitching motility of this protein is enhanced by calcium, which may provide the bacterium an adaptive advantage in environments with high calcium concentrations.
Subcellular location: Fimbrium {ECO:0000305|PubMed:25217013}.
Interaction partners:
Sequence:
MLVMGRDHKLYYEAYNDASDLDGDGVLDVGYKPDKITYYGYYNSNVCYRANGTMFQAMSVANGSNGKKCTGAWSGDFLNYLTTSRMDALRKVLFGGYREVDTLTQTILRASYTPQDAHSWGKEYASVSHDGYDISDYAPLSAPGSGHYHLFAVTTLSDNGIPQLRVLADTTFRVWNWVSIERPVAGSDCFTPENKRVSCVSGGSRGISDYPLRVEVCSVADELRESNCKLYQNNTSYKPTGILHDYGENDRMYFGLLTGSYQKNITGGVLHSNVSNFSREINPLTGQFCLNGNCGGGGDVKGIVHTISSFRMLDFNYKDYTYGCGWIATRPVKEGECWMWGNPVAEMMYETLRYFGGATAPRPEYDINSSSQDIATLQLSHPGWKPPYTSVDKGGSGYSVCAQPTMTVFSDINPSYDDKLPGSHWSNFSGSGDPASMRNLDVSAEADRIWEAEGGGSKLFFIGESNNNSDNAPTPKVVSNLSTVRGLSPEEPSKGGTYYSAAVARYGANHKMGGSKFVRTYAVALASPLPKFEFPVGNARVSLVPFAKSVRGFGISATGNFQPTNQIIDFYVQRVANMAGSSGADYDATINGGRPYAEFRINYEDVEQGADHDMDAIALYTIYVNAKNQLVVTLKSEYSAGSIDQHMGYVISGTTRDGVYLEICDLADGHSNDGTRSSCAGQQPYKLNTPPNRLPGYCNATPMPGDCNGLPPVATRIFSVASQGANAVLLKDPLWYAAKYGHDQGVILNSSGGLANYFPVNNALYLRQQVAKAFSAIQSQAGSSGSIAVVGASVSSTSFAVIPSYSSTHDGKDWTGEMTAYRIDANGMIGDVLWLASAGVPSGTSAIAKRVIYTALSHVDDTNRASVVRRFVAEKLVDSSSGDVATDAAQVFGRLGYTPRGVIDDFGSSVTPNQLVNYLRGDKRMEGATLNTAPFRRRFGPLGDMINSIPVVATRRANYGWATASGLPQVQRDSYSAFINARQNSTAAEHIFVGANDGMLHAFDDKGTERFAYVPNGVLHHLGFLANPEYQHHYYVDGKSTLSDAYLDGSWRSVLVGGTGAGGRSMFALDVTSPSTFNESNVLWEMNSENDDDMGYTMGKPYIVPLQNGSWAAIFGNGYNSTNGRAVLFIVNLATGQLIRKIEARDGIDPDGSDPANMGYNGLGNLAVLDTDGDGLVDMVYGADLHGNLWKFNLSGKDPQRWGIAYKDGLGNPIPLFVARNPQGYRQPITGGLEVAVGPSAGYIIYFGSGRYFAANDNNSKDLSTLYGIWDSGSPVIAGRAALSAQIIQASDHPTSPDTRIVTRRPLSYLSKHGWYVDLVVQGQDPQGERSIATPLLQGGRVFFSTYVPGVSVNCASGGSNWLYVLDAASGGAALGQVNIPSRGSRSSIGNSDTGAVSTGGDAPIQSVAMTRTAPRQPVFCNPGEQGCPLVPETHAAPLDTRCSEVIIDPNDPTRSISLFRACGRQSWRQLR
Protein: Lethal (3) neo38, isoform L (A0A0B4KGA3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMNFSAFGGPFSGIHQFAAKFDAQTPGAFGTPPAAAANAAAAAAAAGTDNHVQRYQTNGNHFNQNVPNVSAANNMQYGQNISIPYSQPQGDLNFLNAAAAADHKGKIHPKIERDREEVLNQQILQNVNQSWQTLANTANTVDYSSHLLSATLPISIQHFLKYSETIKKESTGDVLKNGTNLASLALGGVALTPSNNGANGGHHNGLVGMDHGGHMTNMTDANGAALTNGASNGVNGNANGTVTNGGAGAVSSSGSVGTTNASGGTGTASGKKTKKKKPPKEKKPRPKPGEIRETKALDGSTLYCCPECQMAYPDRSLIEQHVISHAVERRFVCDICNAALKRKDHLTRHKLSHIPDRPHVCNICMKSFKRKEQLTLHIVIHSGEKKHVCIECGKGFYRKDHLRKHTRSHIARRVKSEVSAQNVNGSAGGGGGGGGGNSAQSNALHGSXGSYKDFW
Protein: Uncharacterized protein IRC8 (Increased recombination centers protein 8) (P47046)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Protein Kish
Sequence:
MCHNSVRSGNKAGFLGIKFGSALLSIATGAIAIALLCKFHDHEAVLIVIVCSTLLYGIPSLISFITETVFAPSKFHIGYFYNVLNFALPLITMGCTVDYFHNTLRSPISVQSESHRVYITTLDSLLIFTLFINGIQLGFFLKDGNANNFGSSSNNISTDQYDKEANAVENGRFVPLKNSSQTLTPDLELLHGSPKSMNGVAWLINELSTNSNTNANKTISSDENSNSSVIRHKLGPISTSKCPKKPSHSHFSKLKKYNSFFLGPKENRYKRNTQQATKVPTEKKSNHRSSQYVSRLSTISDISKSFLNFLALNEKNGNSTSTARTPSEGRVSIIINEGNNTLKYKTPHDSHTIDSPNLELEREAIGRINSALLPACLRVTDKMISPQQSTQNEDSYQATPLIPQVEVDDDFYVGDILMTNELQDIPQVPRISSDIEDDFEQQYTKHVDLPARVTLEMWEKDQEKILQKVTTNRDKSKLLPPFRFTSESDMDPSTSTELEVELHAQNNFSFPFKSAGLQIATSDQFNQQEFKTSDTISELDEYLHDPSIQEEDASQLIESSLNQNNLSSTTIDNGPKDMSRFSTRHSPTKSIISMISGSGSVKHQHSHSTLSNFFTGHSRNNSQINQLLQGSSSNMMSNTSPHSSPTKSLRMRFGKKLSLSNISDTMSPYEGSTTDPINYSFGHGHNKNQSIDFSYVRTLQSSHSPTKSTSGNSRRDSLNNDRTQSTVNERALRTASTLFYLQHNNATCTLNGEEPVLDTPQSIQSSSSGSEQESAGSGSGYPEVVFSEYDREKWNVLRNLKEIAPEKTIESGPVEELVSPSK
Protein: LD15419p (Q86PA1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLMDQQTKRHRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIMLGTLGVQLPTAPGQLIGARGAGVATMNPLAMLQNPTQLLQSPAAAAAAQQAALISQNPFQVQNAAAAASIANQAGFGKLLTTYPQTALHSVRYAPYSIPASAATANAALMQAHQAQSVAAAAHHHQQQQQQQHHHQQQTHNAHVAAAQQQQQSHHNAVSNPASQAHSAAAAAALAANAANGAGAAGAHSLAAAAQQAGLMAGNPLNAAAAAAAAAANPAAAYSNYALANVDMSSFQGVDWSTMYGMGMYV
Protein: Elongator complex protein 5 (I3L1Q3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRPTDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEK
Protein: Single-stranded DNA-binding protein WHY1, chloroplastic (Protein WHIRLY 1) (ZmWHY1) (B2LXS7)
Organism: Zea mays (Maize)
Function: Single-stranded DNA and RNA binding protein that maintains plastid genome stability by preventing break-induced and short homology-dependent illegitimate recombinations. Functions in RNA metabolism and is involved in the maturation of the atpF and 23S ribosomal RNAs.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:18676978}. Nucleus {ECO:0000250|UniProtKB:Q9M9S3}. Note=Can localize to both chloroplast and nucleus. {ECO:0000250|UniProtKB:Q9M9S3}.
Interaction partners:
- Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic
- Protein PLASTID TRANSCRIPTIONALLY ACTIVE 12, chloroplastic
- Chloroplast RNA splicing1
- Ribonuclease III domain-containing protein RNC1, chloroplastic
- Regulator of telomere elongation helicase 1 homolog
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE homolog, chloroplastic
Sequence:
MPPPAPLFLSLASTPPPALMPVHHPRAPQSLTLVPPVASSRKAAAVPACPVASPRHSDYFDPRAPPPPRGDGGYGRPPNGAQDGRVFTSYSIYKGKAALSFDPRPPLFVPLDSGAYKVAKEGFVLLQFAPAVATRQYDWTRKQVFSLSVWEIGTLLTLGPTDSCEFFHDPFKGRSEEGKVRKVLKIEPTPDGNGRFFNLSVQNRLINVDESIYIPITKGEFAVIVSTFNYIIPHLMGWSTFVSSIKPEESRPYSRPQSTSEYEWRR
Protein: NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor (A0A5K1VW66)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Interaction partners:
Sequence:
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL
Protein: Probable LRR receptor-like serine/threonine-protein kinase At1g14390 (EC 2.7.11.1) (Q9M9S4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Probable LRR receptor-like serine/threonine-protein kinase At1g53430
- LRR receptor-like serine/threonine-protein kinase RGI5
Sequence:
MHSSSKSQAFSLTFLLFLFLLPSVSESQLISSESRTLLEIQKHLQYPPTLRSWSNWTNFCYLPSSPSFKILCFNGHVTELTVTGNRTVKLPGRFSSDSLFTVLTKLSNLKTLSLVSLGISGPLPSQIIRLSSSLQSLNLSSNFISGNIPKEISSLKNLRSLVLANNLFNGSVPDLRGLSNLQELNLGGNKLGPEVVPSLASNLITISLKNNSFGSKIPEQIKKLNKLQSLDLSSNKFTGSIPRFLLSLPSLQNLSLAQNLLSGSLPNSSLCNSKLRILDVSRNLLTGKLPSCFSSKKQTVLLFTFNCLSINGSPSAKYQRPVTFCENEAKQAVAAVKSDTKDKERKEEDTGIELGLVIGIIIGVILVSAVLAGLVLVRMRKSRSKEEPLEANNVDQVTVCSNTTRSTTSKTVPDLRRVPQTMRSAVIGLSPYRVFSLEELEEATNNFDAENLCGEQLYKGCLREGIAVTVRCIKLKQKNSTQNLAQQMEVLSKLRHMHLVSVLGHCIGTYQDHHPYAGSTIFIVQEYISNGSLRDYLTDWRKKEVLKWPQRMSIAIGVARGIQFLHTGVAPGIFGNNLEIENVLLDETLTVKLSGYSIPLPSKVGAESPSNEDGEKEDVYQFGVILIQIITGKVIAAASSELGSLKLQLENSLRDEPSVLRSLADPCVRGTYAYESLRTTVEFAINCLCEDQRKRPSIEDVVWNLQYTIQVQQGWTSSENLGLGGSEL
Protein: Aminopeptidase (DUF3754) (Q8RWC3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAEQHNKEVIRLEPESVIPILKPKLIMTLANLIEHSNDRQEFLKLCKRIEYTVRAWYLLQFEDLMQLYSLFDPVHGAQKIQQQNLTSQEIDVLEQNFLAYLFQVMEKSNFKITSNEEMEVAHSGQYLLNLPIKVDESKLDKKLLKRYFEEHPHENIPDFSDKYVIFRRGIGLDKTTDYFFMEKLDVIISRFWSFLMRITRLEKLRAKRSSSLNKKDPKKDDEPNPDTDNDELYVERIRLENSKLSFKSFLSKLTIQEPTFDRMIVVYRRASSKTNLERGIYVKHFKNIPMADMEIVLPEKRNPGLTPMDWVKFLISAVVGLVAVLTSVEMPKSDPWVIIAILSTVLGYCAKTYFTFQQNMATYQNLITQSMYDKQLDSGRGTLLHLCDDVIQQEVKEVMICFYILMEQGKATLEDLDLRCEELIKEEFGARCNFDVEDAVQKLEKLGIVARDTIGRYYCMGLKRANEIIGTTTEELVLKAKQGVTPS
Protein: Galectin (Q9VPI6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform B
Sequence:
MTAIILLACHSVRELVDLSDALWQNTFNIERSLNYYRIKRRLELFRFHCRELWLRQVSKTSDPMHRKAGIDFAAIEAGADCVLNMDAFDDTTTELHKRFLQAEGTRPFPSDCISGIEVVDGNEFKASFYEYADAVPKYFNDQIGKLSEGISFTVTGNLSVNCERFSINLVYNNDSRDVALHINPRLPQNYIVRNTKVQDIWGNEEVSSALPFLLSRGEEFSIQVLVTEACYMISVNGQHFAAYTHRIPYRDVRILEVKGDVSNVEMKRTLVLKYPERLPQSEANNIELHIDDGINEIDASVEETVKIPHEWCIISAPNTQSDSSPKRNNSSNDLGLTLPYYGALPPNSLVDGRCLKIEGRVRLLPHSFYINLQQGQDIWPHPVIAFHLNPRFSKASSGAIGKAVVCRNAWLNGAWAQEERSEFDTNFRPGRSFCLAIVCTKTSFEVYVNRQFMTDFKYKVSPEVVDTVYIQGDVKLWNVTLEKNQMIKGKNMRVYQNPWFFSE
Protein: Gamma-soluble NSF attachment protein (N-ethylmaleimide-sensitive factor attachment protein gamma) (Q6FHY4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004170, ECO:0000256|RuleBase:RU367013}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170, ECO:0000256|RuleBase:RU367013}.
Interaction partners:
Sequence:
MAAQKINEGLEHLAKAEKYLKTGFLKWKPDYDSAASEYGKAAVAFKNAKQFEQAKDACLREAVAHENNRALFHAAKAYEQAGMMLKEMQKLPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENVDPEKAVQLYQQTANVFENEERLRQAVELLGKASRLLVRGRRFDEAALSIQKEKNIYKEIENYPTCYKKTIAQVLVHLHRNDYVAAERCVRESYSIPGFNGSEDCAALEQLLEGYDQQDQDQVSDVCNSPLFKYMDNDYAKLGLSLVVPGGGIKKKSPATPQAKPDGVTATAADEEEDEYSGGLC
Protein: Expp1 protein (Q8VZ18)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- 2-
- 2-
- Ribosomal protein S5/Elongation factor G/III/V family protein
- Elongation factor 2
Sequence:
MFSSKTLTLLVFSAVILTVALGGDSGGSGNTNTIYSPCSDTRIQRSDGFTFGIAFSSRPSFFINQTVLLSPCDRRLSLAAMNSQFSVFRPKIDEISLLSINTSAFFPDNYGGYMVAFAGRKYAARSIPAFIANSTFIVTSFTLVMEFQKGRLQNLYWKRDGCASCKGNQNFVCLNKQDCAIRTPSCKGRGGAVDCSLGIQLAFSGTDKHLAVLNSWYEVENLKQYSLYGLYSNLKSSLTNQFNNFF
Protein: Protein NETWORKED 2A (P0DMS1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plant-specific actin binding protein. Associates with F-actin at the plasma membrane in growing pollen tubes. May be part of a membrane-cytoskeletal adapter complex.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22840520}. Note=In growing pollen tubes, forms foci at the plasma membrane, but not at the pollen tube tip. {ECO:0000269|PubMed:22840520}.
Interaction partners:
- DNA-directed RNA polymerases II, IV and V subunit 11
- DNA-directed RNA polymerase subunit
- RNApolymerase 14 kDa subunit
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase II subunit 4
- SIN-like family protein
- DNA-directed RNA polymerase III subunit 2
- DNA-directed RNA polymerase I subunit 2
- DNA binding / DNA-directed RNA polymerase
- DNA-directed RNA polymerase III subunit RPC9
Sequence:
MLQRAASNAYSWWWASHIRTKQSKWLEHNLQDMEEKVEYTLKIIDEDGDTFAKRAEMYYRKRPEIVNFVEEAFRSYRALAERYDHLSRELQSANRTIATAFPEHVQFPLEDDSDENEDYDGRPRKPPKHLHLIPKGINIPEVPDIPKKKDFRSQSMMLSRKGPADLKRNVSSAQAKREAAIVRSGLSKEEGLEEIDKLQKGILALQTEKEFVRSSYEESYERYWDLENEVTEMQKSVCNLQDEFGLGASIDDSDARTLMASTALSSCRDTLAKLEEKQKISIEEAEIEKGRITTAKERFYALRNKFEKPESDVLDEVIRTDEEEEDVVQESSYESEREDSNENLTVVKLAEKIDDLVHRVVSLETNASSHTALVKTLRSETDELHEHIRGLEEDKAALVSDATVMKQRITVLEDELRNVRKLFQKVEDQNKNLQNQFKVANRTVDDLSGKIQDVKMDEDVEGAGIFQELPVVSGSEDSRDDLKSVSTEKTKKDVIAVKESEDGERAQEEKPEIKDSFALSETASTCFGTEAEDLVTEDEDEETPNWRHLLPDGMEDREKVLLDEYTSVLRDYREVKRKLGDVEKKNREGFFELALQLRELKNAVAYKDVEIQSLRQKLDTTGKDSPHQGEGNNQLEHEQGHHETVSISPTSNFSVATTPHHQVGDVKRTPGRTKSTEVRVKFADVDDSPRTKIPTVEDKVRADIDAVLEENLEFWLRFSTSVHQIQKYQTTVQDLKSELSKLRIESKQQQESPRSSSNTAVASEAKPIYRHLREIRTELQLWLENSAVLKDELQGRYASLANIQEEIARVTAQSGGNKVSDSEISGYQAAKFHGEILNMKQENKRVSTELHSGLDRVRALKTEVERILSKLEEDLGISSATEARTTPSKSSSSGRPRIPLRSFLFGVKLKKNRQQKQSASSLFSCVSPSPGLHKQSSYSRPPGKLPE
Protein: UDP-glycosyltransferase 72E3 (EC 2.4.1.111) (Hydroxycinnamate 4-beta-glucosyltransferase UGT72E3) (EC 2.4.1.126) (O81498)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the O-glucosylation of monolignols (alcohol monomers of lignin). Glucosylates coniferyl alcohol to form coniferyl alcohol 4-O-glucoside. Glucosylates sinapyl alcohol to form sinapyl alcohol 4-O-glucoside. Possesses low activity with sinapate as substrate.
Interaction partners:
- Cytochrome P450 84A1
- F5F19.5 protein
- Flavone 3'-O-methyltransferase 1
- UDP-glycosyltransferase 72E2
- Cytochrome P450 84A4
- UDP-glycosyltransferase 72E1
- Peroxidase 13
- Cinnamyl alcohol dehydrogenase 8
- Aldehyde dehydrogenase family 2 member C4
- Peroxidase 73
Sequence:
MHITKPHAAMFSSPGMGHVLPVIELAKRLSANHGFHVTVFVLETDAASVQSKLLNSTGVDIVNLPSPDISGLVDPNAHVVTKIGVIMREAVPTLRSKIVAMHQNPTALIIDLFGTDALCLAAELNMLTYVFIASNARYLGVSIYYPTLDEVIKEEHTVQRKPLTIPGCEPVRFEDIMDAYLVPDEPVYHDLVRHCLAYPKADGILVNTWEEMEPKSLKSLQDPKLLGRVARVPVYPVGPLCRPIQSSTTDHPVFDWLNKQPNESVLYISFGSGGSLTAQQLTELAWGLEESQQRFIWVVRPPVDGSSCSDYFSAKGGVTKDNTPEYLPEGFVTRTCDRGFMIPSWAPQAEILAHQAVGGFLTHCGWSSTLESVLCGVPMIAWPLFAEQNMNAALLSDELGISVRVDDPKEAISRSKIEAMVRKVMAEDEGEEMRRKVKKLRDTAEMSLSIHGGGSAHESLCRVTKECQRFLECVGDLGRGA