wanglab/gogpt-training-data huggingface dataset:
Protein: Periviscerokinin-1 (Lom-PVK-1) (P83382)
Organism: Locusta migratoria (Migratory locust)
Function: Myotropic peptide; increases the frequency of contraction of the heart and stimulates amplitude and tonus of the foregut.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
AAGLFQFPRV
Protein: Histone H2B.5 (HTB7) (Q9SF55)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Interaction partners:
- Histone H4
- E3 ubiquitin-protein ligase BRE1-like 1
- E3 ubiquitin-protein ligase BRE1-like 2
- Histone H3.1
- Histone H3-like 5
- Histone H3.3
- Histone H3-like centromeric protein CENH3
- Histone H3-like 3
- Histone H3-like 1
- Histone H3-like 4
Sequence:
MAPKAEKKPSEKAPKADKKITKEGGSERKKKTKKSTETYKIYLFKVLKQVHPDIGISGKAMGIMNSFINDTFEKIALESSRLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSS
Protein: bZIP transcription factor 50 (OsbZIP50) (OsBZIP74) (Q69XV0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor involved in endoplasmic reticulum (ER) stress response. Acts downstream of the ER stress sensors IRE1, BZIP39 and BZIP60 to activate BiP chaperone genes.
Subcellular location: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22050533, ECO:0000269|PubMed:22199238}; Single-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:22050533, ECO:0000269|PubMed:22199238}. Note=The bZIP domain is translocated into the nucleus in response to ER stress. {ECO:0000269|PubMed:22050533, ECO:0000269|PubMed:22199238}.
Interaction partners:
- Serine/threonine-protein kinase/endoribonuclease IRE1
Sequence:
MDVEFFADLDLDALLASFSSSAAAAGSGVSGLFAPSPPHDAEAGSPESVSSRRPSPSREAALSEIERFLMEEGPAAEEGVGAEDFFDALLVDGGEEEEEEEGKGSEAGGSTDGDSGKENEVATPDAEKEDVEAEVDGDDPMSKKKRRQMRNRDSAMKSRERKKMYVKDLETKSKYLEAECRRLSYALQCCAAENMALRQSLLKDRPVGAATAMQESAVLTETLPLVSLLWLVSIVCLLPVPGLPNRNPVARSSAGRDLATVTGKKTSSEQQLEETLLLHGRRCKGSRARIKLDTGPFRLAAAAC
Protein: Zinc finger protein 37 (Zfp-37) (O88553)
Organism: Rattus norvegicus (Rat)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Solute carrier family 46, member 2
Sequence:
MATPEPAESDAEWEQLEPGQRNLYKDTKLETCSNPASMGNQDPKQGLVSKLDGEEERWSSVRANKNSSSSLHRLKKTGTSAKVQQDGAQTEGKQKFQRKLTSEVTFRKKSSNSKKSSECTLLEKKNVHSKHDPSEKRLHKSNLYGKNLNQNLDLPSQIKISAKKKPDTANEYRKSLSHSASDVNRDEISTRKKCDKSPNNKLFGKGDKNQTGKKCEKVCRHTASHTKEDKIHTGEKRKSPCRSPSKSDKAPGSGKPYECNQCGKVLSHKQGLLDHQRTHAGEEPYECYECGIAFSQKSHLVVHQKTPTGEKAPYECVQCGKAHGHKHALTDHLRISHTGEKPYKCNECGKTFRHSSNLMQHIRSHTGEKPYECKECGKSFRYNSSFTEHVRTHTGEIPYECNECGKAFKYGSSLTKHMRIHTGEKPFECTECGKTFSKKSHLVIHQRTHTKEKPYKCKECGKAFGHSSSLTYHMRTHTGDCPFECNKCGKAFKQIEGLTQHQRVHTGEKPYECVECGKAFSQKSHLIVHQRTHTGEKPFECYECGKAFNAKSQLVIHQRSHTGEKPYKPYECVECGKAFKQNASLTRHMKTHSEEQSQEED
Protein: UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (O05576)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Alpha-maltose-1-phosphate synthase
- Glucose-1-phosphate adenylyltransferase
- Trehalose-6-phosphate synthase
- UDP-glucose 6-dehydrogenase
- Glycogen synthase
- Glycogen phosphorylase
- UDP-glucose 4-epimerase
- Probable phosphoglucomutase PgmA
- Glucose-1-phosphate thymidylyltransferase
- Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
Sequence:
MSRPEVLTPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVAAEAAAAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKIAMLAKVRRAPALIKVESVVQAEPLGLGHAIGCVEPTLSPDEDAVAVLLPDDLVLPTGVLETMSKVRASRGGTVLCAIEVAREEISAYGVFDVEPVPDGDYTDDPNVLKVRGMVEKPKAETAPSRYAAAGRYVLDRAIFDALRRIDQGAGGEVQLTDAIALLIAEGHPVHVVVHQGSRHDLGNPGGYLKAAVDFALDRDDYGPDLRRWLVARLGLTEQ
Protein: Halocyntin (P86415)
Organism: Halocynthia papillosa (Red sea-squirt)
Function: Has strong antibacterial activity against the Gram-positive bacteria M.luteus, S.aureus, B.megaterium, A.viridans and E.faecalis, and against the Gram-negative bacterium K.pneumoniae. Has less potent antibacterial activity against the Gram-negative bacteria E.coli DH5alpha, S.typhimurium, P.aeruginosa, E.aerogenes and N.gonorrhoeae. Has moderate hemolytic activity against sheep erythrocytes.
Interaction partners:
Sequence:
FWGHIWNAVKRVGANALHGAVTGALS
Protein: UDP-glucuronosyltransferase 3A2 (UDPGT 3A2) (EC 2.4.1.17) (Q8JZZ0)
Organism: Mus musculus (Mouse)
Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Coagulation factor XIII B chain
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Glycine N-acyltransferase-like protein Keg1
- UDP-glucuronosyltransferase 3A1
- Cytochrome P450 2A12
- Cytochrome P450 3A25
Sequence:
MAAHRRWLLMSFLFLEVILLEAAKILTISTLSASHYIVISRVSQVLHEGGHNVTKLLYESANIPDFRKEKPSYQVINWRPPEDQEKKFADLRHRLTEEITYGRSKHHTLLKIHQYFGDLCSQLLSRKDIMDFLKNENFDLVLLDSMDLCSLLIVEKLGKRFVSFLPFQFSYMDFGLPSAPLSYAPVYGSGLTDQMDFWGRVKNFLMFLDFSMKQREILSQYDSTIQEHFVEGSQPVLSDLLLKAELWFVNSDFALDFARPLFPNTVYVGGLLDKPVQPIPQDLENFISQFGDSGFVLVALGSIVSMIQSKEIIKEMNSAFAHLPQGVLWTCKTSHWPKDVSLAPNVKIMDWLPQTDLLAHPSIRLFVTHGGMNSVMEAVHHGVPMVGIPFFFDQPENMVRVEAKNLGVSIQLQTLKAESFALTMKKIIEDKRYKSAAMASKIIRHSHPLTPAQRLLGWIDHILQTGGAAHLKPYAFQQPWHEQYMLDVFLFLLGLMLGTLWLSVKVLVAVTRYLSIATKVKEA
Protein: Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (P53349)
Organism: Mus musculus (Mouse)
Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
Interaction partners:
- Dual specificity mitogen-activated protein kinase kinase 4
- Stress-activated protein kinase JNK
- TNF receptor-associated factor 2
- TNF receptor-associated factor 6
- Dual specificity mitogen-activated protein kinase kinase 7
- NF-kappa-B essential modulator
- Dual specificity mitogen-activated protein kinase kinase 1
- Cell division control protein 42 homolog
- GTPase KRas
- Dual specificity mitogen-activated protein kinase kinase 2
Sequence:
MAAAAGDRASSSGFPGAAAASPEAGGGGGGGGALQGSGAPAAGAAGLLREPGSAGRERADWRRRQLRKVRSVELDQLPEQPLFLAAASPPCPSTSPSPEPADAAAGASRFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREMENKETLKGLHKMEDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEVNNLAAEPQGEGQAGSAAPAPKGRRSPSPGSSPSGRSVKPESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGAFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVESPASLRAVQQPSSPQQPVAGSQRRNQESSFNLTHFGTQQIPSAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGGSGGSLSAGAASGSSQPSISGDVVEACCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADANSRTSQLSISTVLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQAESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTAVPAVFSKLVTMLNASGSTHFTRMRRRLMAIADEVEIAEVIQLGVEDTVDGHQDSLQAVAPTSCLENSSLEHTVHREKTGKGLSATRLSASSEDISDRLAGVSVGLPSSTTTEQPKPAVQTKGRPHSQCLNSSPLSHAQLMFPAPSAPCSSAPSVPDISKHRPQAFVPCKIPSASPQTQRKFSLQFQRNCSEHRDSDQLSPVFTQSRPPPSSNIHRPKPSRPVPGSTSKLGDATKSSMTLDLGSASRCDDSFGGGGNSGNAVIPSDETVFTPVEDKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDAEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMGHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVAVRCLELQPQDRPPSRELLKHPVFRTTW
Protein: Eukaryotic translation initiation factor 4 gamma 2 (A1Z968)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Eukaryotic initiation factor 4A
- Eukaryotic translation initiation factor 4E1
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- Polyadenylate-binding protein
- Eukaryotic translation initiation factor 4G1, isoform B
- Eukaryotic translation initiation factor 4E homologous protein, isoform B
Sequence:
MPLSTYDAAPLLHSYDDSPQRWSGVTNGHQAGVIIDQFRGGKAIIIEGGTSTGDTKSIGGGSDLRLVITANPSEIERNYEQPTNRGGGGGGGVIGVSCGGQTPPTPSVGKTLLNTSPNLLPITTATDTFNNLKNLVKIDKGSSPSSGSNSLGGNYRKGGSNGSGYKSAGGNGGSPAISGNSEGGRNGSRSSGGPTGHFSTGYSKNSVKIRQHDSEVSPRPRRSYQGDSSSSRYYPKNSDILGQGLGGNSDSYNGSSSSGRYQQQDQQGGSHRGSRSNYHSNSDGSYNRSINSNSVGGGGSGAVGSGSGGSNYRSARNYENGNGSNGTQPRYGSGNGNGNSSNSNSSSGYNGSAASSTNSKSSYGASRGGNDGGVSSGYSSNYRDNYEDSPSHQRYNNTNSLERNGGGGSGAGASGGPRSYGRSDADRYGGTPSSRTPNLRNGSASAQISGSTSNSSNISLNSGSASAAGGGTPHSQQQQERSQAGKASTPPPITGRWIPPSLRPQHGLTQSEKNDAVFRRVRGILNKLTPEKFQELSDELLKLDLNSIAILKGVILLIFDKALDEPKYSSMYAQLCKRLSEEAPSFDKEPSNSSTFLRLLIAVCRDKFNNRLKRDENDNRPPPENEADEEERRHLAKQRMLGNVKFIGELNKLDMLSKNVLHQCIMELFDKKKKRTAGTQEMCEDMECLAQLLKTCGKNLDSEQGKELMNQYFEKLERRSKSSEYPPRIRFMLKDVIELRQNNWVPRKLGTTEGPVPIKQIRSDDDSIIRTPFPNRNRDMRNNDRDSDSWMNRFHLNIQPGGYNDMFSGLSVTGASPIVSPFATSNRDRDRDNRQYNNRGDRNRDRDQGGSGGANYGNRYNKHNQNGGGSGGGSSNNRDRDDSRRNNDRDRDRNDGQYGGNQLLGSKELAPRFKRNLITTNQDAVENLQMRPAANSLLFRAASQNQKFPATLPMSTPPNSSGSNNQGSSQGQLSNSHYPMLGTPTSHLINPTRPSSTPSAEYADNRTLLGVQQERGLKATSSSPNFSSGAEKLDLDGQAGRKGSHDGKDQGKNGSVERPSTPAGGIGSAKQQKKDKGPNKEELSKKASQYFKDRFYYDEEEDAEVTEIEIKDIDETKTEEADAAPVEVSEVKEDAAIPVTTPDRFTKLVDGFLELKLPEKALKDVCINLLMEVLDRVNDVFLERAVRLLQTLRKQSNIKPNIVVEIFKQVVNKMNEREALNPRIVSLVASLLAKTICEPALLKLSDIANFTDNGQHYPLFLLVLQQLVKVIGKDALEEKFRASKVDLMNSLPEADRNKERLAGILEDRKLSFLYPLLKVQAEMLKQLQSDPNPNNFYKWIKANVDNKYYKDPGFIQALMTVVVKYVTKETTLADNLDPKEHPEKSVTQKEQQLLENYSQMLQTFLGQNELQLMALYALQTFCYNENFPKGMLCRWFKYLYESEIIEEEAFVLWKEEISDKYPGKGSALFQVNAWLTWLQEAESEDDED
Protein: LRR receptor-like serine/threonine-protein kinase RPK2 (EC 2.7.11.1) (Protein TOADSTOOL 2) (Receptor-like protein kinase 2) (Q9S7I6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Key regulator of anther development (e.g. lignification pattern), including tapetum degradation during pollen maturation (e.g. germination capacity). Together with RPK1, required for pattern formation along the radial axis (e.g. the apical embryonic domain cell types that generate cotyledon primordia), and the apical-basal axis (e.g. differentiation of the basal pole during early embryogenesis).
Subcellular location: Cell membrane {ECO:0000269|PubMed:17419837, ECO:0000269|PubMed:17543866, ECO:0000269|PubMed:18158146}; Single-pass type I membrane protein {ECO:0000269|PubMed:17419837, ECO:0000269|PubMed:17543866, ECO:0000269|PubMed:18158146}.
Interaction partners:
- Protein CLAVATA 3
- Guanine nucleotide-binding protein subunit beta
- Protein WUSCHEL
- Protein TAPETUM DETERMINANT 1
- CLAVATA3/ESR
- Receptor protein kinase CLAVATA1
- LRR receptor-like protein
- Protein phosphatase 2C 29
- CLAVATA3/ESR
Sequence:
MTSLPSSVIKWRFFRRQMPSDVVFSLCLLCFASCLAGKITVLADSDKSVLLRFKKTVSDPGSILASWVEESEDYCSWFGVSCDSSSRVMALNISGSGSSEISRNRFTCGDIGKFPLYGFGVRRDCTGNHGALAGNLPSVIMSLTGLRVLSLPFNSFSGEIPVGIWGMEKLEVLDLEGNLMTGSLPDQFTGLRNLRVMNLGFNRVSGEIPNSLQNLTKLEILNLGGNKLNGTVPGFVGRFRVLHLPLNWLQGSLPKDIGDSCGKLEHLDLSGNFLTGRIPESLGKCAGLRSLLLYMNTLEETIPLEFGSLQKLEVLDVSRNTLSGPLPVELGNCSSLSVLVLSNLYNVYEDINSVRGEADLPPGADLTSMTEDFNFYQGGIPEEITRLPKLKILWVPRATLEGRFPGDWGSCQNLEMVNLGQNFFKGEIPVGLSKCKNLRLLDLSSNRLTGELLKEISVPCMSVFDVGGNSLSGVIPDFLNNTTSHCPPVVYFDRFSIESYSDPSSVYLSFFTEKAQVGTSLIDLGSDGGPAVFHNFADNNFTGTLKSIPLAQERLGKRVSYIFSAGGNRLYGQFPGNLFDNCDELKAVYVNVSFNKLSGRIPQGLNNMCTSLKILDASVNQIFGPIPTSLGDLASLVALNLSWNQLQGQIPGSLGKKMAALTYLSIANNNLTGQIPQSFGQLHSLDVLDLSSNHLSGGIPHDFVNLKNLTVLLLNNNNLSGPIPSGFATFAVFNVSSNNLSGPVPSTNGLTKCSTVSGNPYLRPCHVFSLTTPSSDSRDSTGDSITQDYASSPVENAPSQSPGKGGFNSLEIASIASASAIVSVLIALVILFFYTRKWHPKSKIMATTKREVTMFMDIGVPITFDNVVRATGNFNASNLIGNGGFGATYKAEISQDVVVAIKRLSIGRFQGVQQFHAEIKTLGRLRHPNLVTLIGYHASETEMFLVYNYLPGGNLEKFIQERSTRDWRVLHKIALDIARALAYLHDQCVPRVLHRDVKPSNILLDDDCNAYLSDFGLARLLGTSETHATTGVAGTFGYVAPEYAMTCRVSDKADVYSYGVVLLELLSDKKALDPSFVSYGNGFNIVQWACMLLRQGRAKEFFTAGLWDAGPHDDLVEVLHLAVVCTVDSLSTRPTMKQVVRRLKQLQPPSC
Protein: Probable succinate dehydrogenase [membrane anchor subunit] (Succinic dehydrogenase) (O53671)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable succinate dehydrogenase [iron-sulfur subunit]
- Probable succinate dehydrogenase [iron-sulfur subunit]
- Uncharacterized protein Rv0250c
- succinate dehydrogenase
- Fumarate reductase iron-sulfur subunit
- Succinate dehydrogenase 2 membrane subunit SdhC
- Probable succinate dehydrogenase SdhD
Sequence:
MSAPTANRPAIGVFTPTRAQIPERTLRTDLWWLPPLLTNLGLLAFICYATTRAFWGSQYWVEKYHYLTPFYSPCVSASCQPGASHLGVWFGHFPGWIPLGAMVLPFLLGFRLTCYYYRKAYYRSVWQSPTSCAVPEPRAHYTGETRLPLIVQNTHRYFFYIAVVVSLINTYDAIAAFHSPSGFGFGLGNVILTINVVLLWAYTISCHSCRHATGGRLKHFSKHPVRYWIWTQVSKLNTRHMQFAWITLGTLALTDFYIMLVASGSITDLRFIG
Protein: Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a) (Q96LA6)
Organism: Homo sapiens (Human)
Function: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}.
Interaction partners:
- B-lymphocyte antigen CD20
- High affinity immunoglobulin gamma Fc receptor I
- Polymeric immunoglobulin receptor
Sequence:
MLPRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVPTGARSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKIGRRSARDPLRSLPSPLPQEFTYLNSPTPGQLQPIYENVNVVSGDEVYSLAYYNQPEQESVAAETLGTHMEDKVSLDIYSRLRKANITDVDYEDAM
Protein: Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) (Q2NKQ1)
Organism: Homo sapiens (Human)
Function: Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8BPQ7}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:22637480}; Peripheral membrane protein {ECO:0000269|PubMed:22637480}. Cytoplasm {ECO:0000269|PubMed:22637480}. Note=Recruited to cytoplasmic vesicle membranes via its interaction with Rab family members, such as RAB9A. {ECO:0000269|PubMed:22637480}.
Interaction partners:
- Small G protein signaling modulator 3
- Centrin-1
- Ras-related protein Rab-4A
- Ras-related protein Rap-1b
- Ras-related protein Rap-2a
- Ras-related protein Rab-9A
Sequence:
MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSPKEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK
Protein: rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (Histone-glutamine methyltransferase) (U3 small nucleolar RNA-associated protein NOP1) (Nucleolar protein 1) (U3 snoRNA-associated protein NOP1) (P15646)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Involved in the biogenesis of the 18S rRNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12756332, ECO:0000269|PubMed:2298745, ECO:0000269|PubMed:2686980}. Note=Fibrillar region of the nucleolus.
Interaction partners:
- Something about silencing protein 10
- U3 small nucleolar ribonucleoprotein protein IMP4
- U3 small nucleolar RNA-associated protein 9
- U3 small nucleolar RNA-associated protein 7
- U3 small nucleolar RNA-associated protein 12
- U3 small nucleolar RNA-associated protein 14
- U3 small nucleolar RNA-associated protein 10
- Ribosomal RNA small subunit methyltransferase NEP1
- H/ACA ribonucleoprotein complex subunit GAR1
- U3 small nucleolar RNA-associated protein 5
Sequence:
MSFRPGSRGGSRGGSRGGFGGRGGSRGGARGGSRGGFGGRGGSRGGARGGSRGGFGGRGGSRGGARGGSRGGRGGAAGGARGGAKVVIEPHRHAGVYIARGKEDLLVTKNMAPGESVYGEKRISVEEPSKEDGVPPTKVEYRVWNPFRSKLAAGIMGGLDELFIAPGKKVLYLGAASGTSVSHVSDVVGPEGVVYAVEFSHRPGRELISMAKKRPNIIPIIEDARHPQKYRMLIGMVDCVFADVAQPDQARIIALNSHMFLKDQGGVVISIKANCIDSTVDAETVFAREVQKLREERIKPLEQLTLEPYERDHCIVVGRYMRSGLKK
Protein: Ataxin 1 (IP08458p1) (Q9W3V7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Putative transcription factor capicua
- Suppressor of hairless protein
- Huntingtin, isoform A
- LD40504p
- Splicing factor 45
Sequence:
MQMHMELSYGRGYDPIGRQPPSLPPPSQQHWSSNGFSDDSASCFRRGSYIELASGAMRRVEDIRTEDFIQSALRSQLFELREATVVRIDWSGCPSLVTLTFSYDTHHAKMDLQVQPGHPMFVYGQGWASCDPQLSLQLYELKCQQLQVGDICLSLVPNEQPAAPCPPQPAPPPPCPPPSLPPSMEMPVPMGSPPTGSYGFLPFKHPYEMYAQMASFVAVYTQHMMGKLNY
Protein: Probable fimbrial chaperone EcpB (P77188)
Organism: Escherichia coli (strain K12)
Function: Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity).
Interaction partners:
- Common pilus major fimbrillin subunit EcpA
- Probable outer membrane usher protein EcpC
- HTH-type transcriptional regulator EcpR
- Fimbria adhesin EcpD
- Probable fimbrial chaperone EcpE
- Uncharacterized protein YkgL
Sequence:
MKKHLLPLALLFSGISPAQALDVGDISSFMNSDSSTLSKTIKNSTDSGRLINIRLERLSSPLDDGQVISMDKPDELLLTPASLLLPAQASEVIRFFYKGPADEKERYYRIVWFDQALSDAQRDNANRSAVATASARIGTILVVAPRQANYHFQYANGSLTNTGNATLRILAYGPCLKAANGKECKENYYLMPGKSRRFTRVDTADNKGRVALWQGDKFIPVK
Protein: Coiled-coil domain-containing protein 116 (Q8IYX3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25074808}.
Interaction partners:
- Guanine nucleotide-binding protein-like 1
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Sequence:
MARCRHHSGYLADDEASHSMCSARVQLPKKPLVPEMRPACKPGRVPHPPSTCGSSALQGQRRNKRHPQPFGHFLDFLTESQVLDSLETVVEKATERMAAMKTEAGVPLVEVQDPVEVPSGGRRAHARPSLSTVHRHRVRPTLCTGHPNNYPSSSSSMSNCHSSLMAGCLGSHSRDSDLGAQGSLPPVRDKLLLEKNLKRLLQLEREGKGLSQSCSQRDSLLWDSLGSQTSFQWTQEQPLSWFSGLLGSSSGVPEASEPRPGEQEPIFRKREFNKEIKSLLSQLESLDLPGYCPLREPHRTLNFLADHRLFPALQSVVSQAVDKLRGAHCRDGRPLFPTSLEPTSDLPPLGSEPAKPTNGGQPYASPRPTVSSPKMLQRKRKDRGGSPSMSSAQVATRFKLKSPCSSSRFTKKKPLPSISSKSSMSHFSNRLYEELADFLTQQAASLVIRKYEFEKDLSKQLGFFSFPITHVLRDLSLGLKKVKGSRIHLSSETHRSCLLRKLEESKRARQASRLSTSHCSTETPSVQQEPATHTAQDQATEPCRSLYTNLPASRQLSPLEPKLYMSACTGMGSSPPKSKDMDNEGRDKAEIEDEDEDEFKDEDQDEDKDEDGV
Protein: Component of DNA helicase/primase complex (Q77CE7)
Organism: Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Interaction partners:
Sequence:
MDGPAALEDALQILYATDGCAIGFSLMLLTGQEEPGRGAYVVSYNWPGRLAACLGGESPNDVALALADARPLVAFYLLGGPPGGSAAATPRLARLRVHLQQRAGRARARRRTAPRQGPTRARAARAPRRGRHLCAARGHDHALLVATEQLAPRTGRTADDARYVEGQTTVRSALRARPAGRRGLASLYIHHEHKTVAAYRRLYSNSGATPFWFLSKFGPGEKTLVLATRFYVFQAERAGDAATYDLQAVRDCLATYAVAAPPNPSGLAFPDLVSFAALAAFCCRSGYARGAVAAGAPAYVAARIEADLAEVRCLREYIDHDRRSLKVADPEFVAYVYLAYFEGFNRRQITEHLRAVTATEPPDGGEALAPRLAGVSRLRERAVDAFFRHVRAQFNVQSYIEQNVAVAVVRLPPATAEAYARARTYARLLAATANGPGRTICDGAAALRAALDHLEGQAARFGWVLHAPGAPSASAVPGPGLDAALRVGAPDGGASPDATPACCGVSKRLLELAAAAARDGAHPLDGLFGARGTAAPTPVYRVELPRGHQAFAVADGDDWAAVTSVAALDPDEVAVEVAAAAAAAAESGRDALVERDARLTALLTERAACAAGRSDRRSLGPAAPRDQYYVNRNELFNARLAVTNIVLDVDFRLKRPLPRGDLHGAMRSFRRGALAALAALFPEIAADAWPAHPCFFYKSACPSAAASNLGDGDASPSWAAPDRDAGWDEYESALAREGEAQYSCEDVSDPAGARPEETGGAEGAGSAAALTTACGCDDKMGFRVAVPVPAPYIIAGGPTLKGIARLVQHAVMLERPFAEAMSRYLRDFAFVDAAVYTHGHSLRLPFFGKPDAASNVGRWLLPFYVVPERCDDVAAFVAAHRDPHHFHFHAAPPAGGRREARRAHVGGEYVSFFERKAAVNRAAFHGVRVSLRRALAAVGVDGGDRGAVEEFIADVIEAELAPYMAEHYPQAAREYQGAGARLVAAKADWLLAQLVPARAGTAQGFGCLRAAHGRAAQNKARSLVSLSVDSHDRLCASLIQQCFATKCGSNRLGTVFTVDLSGRAARYAARGADC
Protein: Gamete and mating-type specific protein A (EC 3.4.22.-) (Q54ME1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Thiol protease that seems to be involved in the sexual development.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Cell fusion related protein
- Large ribosomal subunit protein uL5
- MatA protein
Sequence:
MKLILVLLCLISTLFVVKGGLSPTEQQIIVSYHNKWRSSPIGPTPSTTIPALKWNATIAAALQSSLDKCDGKFSTMSQYGTNSEWQSWWTPNTYFNLNATLDNIQKGASFYDWNAKGCNSSANYNCQLWTYAVWSKSTSYGCAKTICPDKSEVSCSYYPAGGFKGVLPYTPKTTTPAPTTPAPTTPKPTTPAPTTPKPTTPAPTTPKPTTPAPTTPKPTTPAPTTPKPTTPAPTTPAPTSTLTVDWTSYQTPIRDQGQCGSCWAFASSAALESRYLIKYGTAQKSTLQLSNQNAVNCIASGCNGGWSGNYFNFFKTPGIAYEKDDPYKAVTGTSCITTSSVARFKYTNYGYTEKTKAALLAELKKGPVTIAVYVDSAFQNYKSGIYNSATKYTGINHLVLLVGYDQATDAYKIKNSWGSWWGESGYMRITASNDNLAIFAYNSYYPTF