wanglab/gogpt-training-data huggingface dataset:
Protein: Meckelin (Meckel syndrome type 3 protein homolog) (Transmembrane protein 67) (Q8BR76)
Organism: Mus musculus (Mouse)
Function: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Is a key regulator of stereociliary bundle orientation. Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (sftpc). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A. In non-canonical Wnt signaling, it may act as ROR2 coreceptor.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Interaction partners:
- B9 domain-containing protein 1
- Centrosomal protein of 290 kDa
- B9 domain-containing protein 2
- Transmembrane protein 231
- Tectonic-1
- Tectonic-2
- Transmembrane protein 216
- Coiled-coil and C2 domain-containing protein 2A
- Jouberin
- Transmembrane protein 17
Sequence:
MVTRTRPVAAMAVRSRSSSRTGTAYLLLVLCEVSWAQIFSFPFRRPETCDFNQYFDISALSCAPCGANQRRDALGTSCVCLPGYHMISNNGGPSIICKKCPENMKGVTKDGWDCISCPSGLTAEGKCHCPTGHILVERNVSGSLLAQATCELCDESENSFTKANALGTRCVRCEPTFVNTSRSCSCSEPHTLTGGLCFSNTGNFHQRVISTARYGELGMSLNSEWFAKYLQATAAACWTHANLTSCQALGNMCVMNMNSYDSTTLDACRLFHYIFESTAGLISVHSVPFWRQNLPWLFYGDQPGLAPQVLSTTPLPTNFSFKGQNQLKFVAASYDIRGNFIKWQPLEGGVLQLCPDTERRLDAAYAFGTTYQQNCEISLSKLLVDFSSPVFYDVYLEYTDEEQHRYLWPIPVLNLNLQHNKLFVNQDSSSSKWLLTRRIFLVDAVSGRENDLGNQPRVIRVATQISLSIRLVPNTKNGNIYTPLLTIAYSDIDIKNAHSQSAKISFSVKYEMNQGDASVHTDIALGVLGGLAVLSSLLKTAGWKRRVGSPMIDLQTVMKFLLYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPVQEERFVTYVGCAFAMKALQFLHKFISQISIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTTLFFLEVVGFKNLALMDSSSSLSRNPSDYTAPYSRILRYAVATAIWLVIGIIQVVFFAAFYERFIEDKIRQFVDLCSMSNVSVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAVSSQMRQHYDRIHETLTRRNGPARLLSSSGSTFEQSIKAYHAMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGHSFSSVLYYGNEATLLIFDLLFFCVVDLACQDFVLASFLTYLQQEIFRFIRNTVGQKNLATKTLVDERFLI
Protein: Chromosome 15 open reading frame 39 (H3BMJ2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XVYRNPLCYGLSTCLGEGAVKRPLDVDWTLATGPLLPSADPPCSLAPAPSKGQTLDGTFLRGVPAEGSSKDSSGSFSPCQPFLEKYQTIHSTGFLASRYTGPYPRNSKQAMSEGPSSPWTQLAQPLGPPCQDTGPTHYPPPHHPPPHPPQALPCPPACRHPEKQGSYSPALPLQPLGGHKGTGYQAGGLGSPYLRQQAAQAPYIPPLGLDAYPYPSAPLPAPSPGLKLEPPLTPRCPLDFAPQTLSFPYARDDLSLYGASPGLGGTPPSQNNVRAVPQPGAFQRACQPLPASQPCSEPVRPAQEAEEKTWLPSCRKEKLQPRLSEHSGPPIVIRDSPVPCTPPALPPCARECQSLPQKEGARPPSSPPMPVIDNVFSLAPYRDYLDVPAPEATTEPDSATAEPDSAPATSEGQDKGCRGTLPAQEGPSGSKPLRGSLKEEVALDLSVRKPTAEASPVKASRSVEHAKPTAAMDVPDVGNMVSDLPGLKKIDTEAPGLPGVPVTTDAMPRTNFHSSVAFMFRKFKILRPAPLPAAVVPSTPTSAPAPTQPAPTPTSGPIGLRILAQQPLSVTCFSLALPSPPAVAVASPAPAPAPSPAPARAQAPASARDPAPAPAPVAGPAPASTSAPGDSLEQHFTGLHASLCDAISGSVAHSPPEKLREWLETAGPWGQAAWQDCQGVQGLLAKLLSQLQRFDRTHRCPFPHVVRAGAIFVPIHLVKERLFPRLPPASVDHVLQEHRVELRPTTLSEERALRELALPGCTSRMLKLLALRQLPDIYPDLLGLQWRDCVRRQLGEHGAAPVATGAV
Protein: Transcription factor bHLH63 (Basic helix-loop-helix protein 63) (AtbHLH63) (bHLH 63) (Protein CRYPTOCHROME INTERACTING BASIC-HELIX-LOOP-HELIX 1) (Transcription factor EN 84) (bHLH transcription factor bHLH063) (Q8GY61)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds DNA to G box 5'-CACGTG-3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:18988809}.
Interaction partners:
- Cryptochrome-2
- Cryptochrome-1
- SEC12-like protein
- Protein transport protein SEC31 homolog B
- Protein transport protein SEC31 homolog A
- Protein transport protein SEC24 A
- Protein transport protein SEC23 D
- Adagio protein 3
- Phytochrome B
- Protein SUPPRESSOR OF PHYA-105 1
Sequence:
MNGAIGGDLLLNFPDMSVLERQRAHLKYLNPTFDSPLAGFFADSSMITGGEMDSYLSTAGLNLPMMYGETTVEGDSRLSISPETTLGTGNFKKRKFDTETKDCNEKKKKMTMNRDDLVEEGEEEKSKITEQNNGSTKSIKKMKHKAKKEENNFSNDSSKVTKELEKTDYIHVRARRGQATDSHSIAERVRREKISERMKFLQDLVPGCDKITGKAGMLDEIINYVQSLQRQIEFLSMKLAIVNPRPDFDMDDIFAKEVASTPMTVVPSPEMVLSGYSHEMVHSGYSSEMVNSGYLHVNPMQQVNTSSDPLSCFNNGEAPSMWDSHVQNLYGNLGV
Protein: Interferon alpha-inducible protein 27-like protein 2B (Interferon-stimulated gene 12 protein B2) (ISG12(b2)) (Q8VC49)
Organism: Mus musculus (Mouse)
Function: Functions in the intrinsic apoptotic signaling pathway and may have an interferon-induced antiviral activity.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:21151029}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKRKFVGAAIGGALAVAGAPVALSAVGFTGAGIAAGSIAAKMMSAAAIANGGGIAAGGLVATLQSVGVLGLSTITNIILVAVGTATGARAEGSMGASREQESGPQDPPQELQEPQEPPSCKKQDLNLGKFVGAAIGGALAVAGAPIALSAVGFTGAGIAAGSIAAKMMSAAAIANGGGIAAGGLVATLQSVGILGLSTSTNIILGAVGAATGATAAGAMGACREQEPGLQDLQQEPKEPQEPQELQKQQEPQEPQELQKQQETQETQETQELQKTQEPPSYEK
Protein: Alkaline phosphatase (EC 3.1.3.1) (O60109)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Folic acid synthesis protein fol1
- Probable thiamine biosynthetic bifunctional enzyme
- Low molecular weight phosphotyrosine protein phosphatase
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase C18B5.05c
- Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1
- Acid phosphatase
- Thiamine-repressible acid phosphatase pho4
- Thiamine-repressible acid phosphatase SPBC21H7.03c
- Probable acid phosphatase SPBC4.06
Sequence:
MASERDPLLPVHGEGPESPSRRNWKTWIKHGILLILVLSTVIFFYFFSSHKSKGTNEKPKFVIMMVSDGMGPGSLSMTRSFVETLNDKEGYRLPLDEHLIGSSRTRSSSSLITDSAAGATAFSCANKTYNGAVGVLDNEKPCGTILEAAKEAGYLTGIVVTSRVTDATPASFSAHAANRFMQDLIAEYQVGMGPLGRSVDLLFGGGLCSFLPKSTYRSCRSDNLDLLKYARKKEGFQILLNRTDFDELSNAQLPLLGLFSDYHLSYDIDYQPEVQPKLSEMVETALDVLLNATNEDTSKGFFLLIEGSRIDMASHNNDPIAHVYEVMEYNRAFEIASAFVEKNGGSLISTSDHETGGLTVGRQVSKKYPEYLWKPQVLSLALHSIEYLASAIVNHNQNTLLPYIEQFVLPAIGIPDPNPKQIHDIYVARHNIFNLINVLSDIVSVEAQIGWTTHGHTAVDVNVYGVGEVTEHLRGNMENIEIGQFMEIYLNVSLSDVTEKLKDAPIHGAPDRPSLVETSFSDRLVGFGADLF
Protein: Cell division cycle protein 27 homolog (I3L3H6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCLPNSCTTQVPNHSLSHRQPETVLTETPQDTIVQNKPKTGRSLLGGPAALSPLTP
Protein: SPRY domain-containing protein (Q583D8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSASTSFHHPSRRTSKDSTESSLWGLTNSNVGATSLCQAPVEPAAARSWSGDTAREYEVSAGDVSGYDDDCGRSGRSKVSRALQSSGFGNINSLALAAIVQRACIEEEVFLRGRIQLQQLESWKKLRVQALQKQPRSLTGGCSVSQRVVRATPRRESAICGPPPHQPQKQQFETQLQEQPLTPRQLPLEWPSGDSNCRRTQLSEAHKVAATRQVTKRERRLRGQDRRIMERELQGVQEAEAKALREARTNAERIQVLEEQLSATQQTLACTAAPNRRVAEELQLSDRRVDVKQLQLENTAPVVGNGEVGADQKEYTEGLGTTMTTLDEENRGVPATRHQEAPCEPNDSQGPQGEQEEQLSCELQGHWLSDERITEVERRLREVACTIEKELIEGAKAAETQAKLLQHSQSMCEELQHSYREKVQEIVDQAGRYEAVLVARDASTAATTSYLRQEADAHRKQCRELQQLVLRERVAMSITFEAHQAEASRLRQTLDALQEGKLLLGAEVRCADLAASRQRLQEELTLGRQAEAFLRQTSSEVAGLLMTLTVAQQEQHHLSSVPHDMQSELDQPQPQAEDRKKQRQQRGLSLRDGNATARGERMNLSLEQCVGVNKDGERAHRSSPRDYCEEPKEGQCQFRLSRKNAGESEEESPNERSVATSHALSPQDCSVSRIEHSVAQRNVESAPLLKPISVRPGAVAPELFKHLEGHLESHLHELETRVTEAIEALSLVNRQVVPQQQGEQLQAGGSQRLTLTNSIVTEDAVTRRAEKTPAGNCVVKLLDAVSALNVVLPYFDWLSCQGVPERIPRRVDKRLEGSLRQQLGALRFIVQDMEEKRNATAAPPALSGSSTCSGLSGGLLIYSLTSALKEGMEVLSAVGYVGKLASPTKNEVTVQTSTRSSGFCCPLVATMLLEGHLTPSSRRPYELLKQLWYPRSFLQSPRPPCADDAQPRHTFAAVGGRLELAEEGRSIRRLPLPPVVDIMSCSALGALDHQSFSVSPCALSSLSSSLPSPLCFIYTVRVVAPCGNVLMGFSDRRLPLEVFAPALNHLSYSNSYWLHLGRGTLYCPRLGIADLPYSPFARSNSIEVNGEVTCVLDMAARTIRFKCGDADCGVAFGGVDLSQPLFPAFEFDCGGGALKFV
Protein: Enoyl-CoA delta isomerase 3, peroxisomal (EC 5.3.3.8) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase) (Q78JN3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the isomerization of trans-3-nonenoyl-CoA into trans-2-nonenoyl-CoA. May also have activity towards other enoyl-CoA species (Probable).
Subcellular location: Peroxisome {ECO:0000269|PubMed:24344334}.
Interaction partners:
- Trifunctional enzyme subunit beta, mitochondrial
- Enoyl-CoA delta isomerase 2
- 3-ketoacyl-CoA thiolase B, peroxisomal
- 3-ketoacyl-CoA thiolase, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Acetyl-Coenzyme A acetyltransferase 3
- 3-ketoacyl-CoA thiolase A, peroxisomal
- Cocaine- and amphetamine-regulated transcript protein
- Acetyl-CoA acetyltransferase, cytosolic
- Peroxisomal acyl-coenzyme A oxidase 1
Sequence:
MPKPGVFNFVNKATWDARNALGSLPKETARKNYVDLVSSLSSSSEAPSQGKRGADEKARESKDILVTSEDGITKITFNRPTKKNAISFQMYLDIMHALKNASTDNSVITVFTGTGDYYSSGNDLKNLINDAGEIQDVVATSTKILREFVNCFIDFPKPLVAVVNGPAVGIAVTILALFDAVFASDRATFHTPFSQLSQIPEACSTYMFPKIMGPTKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYSKLSPNVMRISKELIRKHEKQKLYTVNAEECAAALERMPREEYAKALRNFLFRKAKAKL
Protein: Large ribosomal subunit protein mL48 (39S ribosomal protein L48, mitochondrial) (L48mt) (MRP-L48) (Q2YDI5)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11551941}.
Interaction partners:
- Large ribosomal subunit protein mL40
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL13m
- Small ribosomal subunit protein mS22
- Large ribosomal subunit protein mL51
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein mL45
- Small ribosomal subunit protein mS40
- Large ribosomal subunit protein mL62
- Small ribosomal subunit protein mS29
Sequence:
MNGALGKVLCLKNDTIFKQAFSLLRFRTSGENPVYSAGGILLTTSRHYRSKPTHGIGRYKHLVKPEEPKKKKGKVEIRAINVGTDYEYGTLNIHLIAYDMALTESYAQYVHNLCNHLSIKVEESYAMPTKTMEVLQLQDQGNKMLLDSVLTTHERVVQISGLNATFAEIFLEIIQSNLPEGVKLSVREHTEEDFKGRFKARPELEELLAKLN
Protein: Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII) (Q9UBF8)
Organism: Homo sapiens (Human)
Function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
Subcellular location: Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus {ECO:0000269|PubMed:22124328}. Golgi apparatus membrane {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:28289207}. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, PubMed:27009356, PubMed:28289207). GGA2 is also involved in the recruitment (PubMed:28289207). {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:28289207}.
Interaction partners:
- Ras-related protein Rab-11A
- Golgi resident protein GCP60
- Neuronal calcium sensor 1
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphatidylinositol 4-kinase type 2-beta
- ADP-ribosylation factor 1
- Phosphatidylinositol 4-kinase type 2-alpha
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- Phosphatidylinositol 4-kinase alpha
Sequence:
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
Protein: Protein disulfide-isomerase-like protein of the testis (Q9DAN1)
Organism: Mus musculus (Mouse)
Function: Probable redox-inactive chaperone involved in spermatogenesis.
Subcellular location: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- A disintegrin and metallopeptidase domain 3
- Calreticulin-3
- Calmegin
Sequence:
MELLWTPLLLVAACLSEVLGSPEIDTGINISQPLHILEDHNLMVLTPAGLTQTLNETRFLMVIFHNPSLKQSRKLAKELGKAAEIFGKGKNGLGFGKVDITKETELQQEFDITHAPELKLFFEGNRLKPISCKDVVESTALVVWLRRQISKKALLFNNSDEVADFVKSRPLVIVGFFQDLEEEVAELFYDTIKDFPELTFGAIQIKNSFGRFHVILDSVLVFKKGKIVKRQELINDSTNKDHLNQVIKQQLTGFVIELNPENKDLIYELNILNHMLLFISKSSEPYSTISRHYRQIAKEFQNKILFVLVNADEPKNKRIFEYFQISRVNVPSVQILNLSSDGRYKMPTDDINFESLKKFCNSFLSKTAKKHKASEEIPKYWDQGPVKKLVGKNFNVVVLDKEKDVFVMFYAPWSEKCRVLLPLLEELGIKYQNHSTVIIAKIDITANDIQLANPEQYPFFRLFPTDSQEAVMYKGEHTMKGFCDFLESHVKVRIEEEDELLYIEQNEEEEVLAEPEIQLIEKLPENPLLKIEDTSKQDRPVKESPVLDSIRKPEEPERRKETAEREAAAAQPKEQPKPERKLEVKEEL
Protein: Outer dense fiber protein 1 (Heat shock protein beta-10) (HspB10) (Heat shock protein family B member 10) (Q14990)
Organism: Homo sapiens (Human)
Function: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q61999}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61999}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q61999}. Note=Localizes to the manchette in elongating spermatids and to the sperm flagellum. {ECO:0000250|UniProtKB:Q61999}.
Interaction partners:
- Sperm-associated antigen 4 protein
- Outer dense fiber protein 2
- Speriolin
- A-kinase anchor protein 3
- Centlein
- Coiled-coil domain-containing protein 42
- Ornithine decarboxylase antizyme 3
- Outer dense fiber protein 4
- SUN domain-containing protein 5
- Heat shock protein beta-9
Sequence:
MAALSCLLDSVRRDIKKVDRELRQLRCIDEFSTRCLCDLYMHPYCCCDLHPYPYCLCYSKRSRSCGLCDLYPCCLCDYKLYCLRPSLRSLERKAIRAIEDEKRELAKLRRTTNRILASSCCSSNILGSVNVCGFEPDQVKVRVKDGKVCVSAERENRYDCLGSKKYSYMNICKEFSLPPCVDEKDVTYSYGLGSCVKIESPCYPCTSPCSPCSPCSPCNPCSPCNPCSPYDPCNPCYPCGSRFSCRKMIL
Protein: Sperm protein associated with the nucleus on the X chromosome C (Cancer/testis antigen 11.3) (CT11.3) (Cancer/testis-associated protein CTp11) (Nuclear-associated protein SPAN-Xc) (SPANX-C) (SPANX family member C) (Q9NY87)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10626816}. Nucleus {ECO:0000269|PubMed:10626816}. Note=Associated with nuclear craters.
Interaction partners:
- Sperm protein associated with the nucleus on the X chromosome B1
Sequence:
MDKQSSAGGVKRSVPCDSNEANEMMPETSSGYSDPQPAPKKLKTSESSTILVVRYRRNVKRTSPEELVNDHARENRINPLQMEEEEFMEIMVEIPAK
Protein: Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C) (C1IIX1)
Organism: Penaeus merguiensis (Banana prawn) (Fenneropenaeus merguiensis)
Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents (By similarity). Has bacteriolytic activity against Gram-positive bacterium M.luteus, and Gram-negative shrimp pathogenic bacteria V.alginolyticus, V.parahaemolyticus and V.vulnificus. May play a role in host defense.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P85045}.
Interaction partners:
Sequence:
MRVLPLALLVGLLAVSDAKVLGKCEFARLLETRYNLSRNDIKNWVCIAEFESSFNTAATNRNRNRSTDYGIFQINNKYWCGSDYGKNVCGIPCSDLMSDDITAALRCAETVRRATERYRGRGKGYTAWVAYNSKCKKRDLDQYMAECWSRGSNSIFPF
Protein: META domain containing protein (Q4QEA3)
Organism: Leishmania major
Interaction partners:
Sequence:
MTTADDVCGAYTLSHCDGKVAPTKATLTIHRCGEILTAHVTVVNDLRGTVQYENCHIVGSLHSTGNEASPAQESVEQALSKGFADGFNVVVEMNQVLLKNANSAFVFARLSKLSDLNGEHAIIAINDQPPNQEMTMIFTPDGNGGSFVAANIANSLRGNCQIDAGLLRGDLATTQSEADESLMQVEKLISEGFQQGFHVCMNESGILLQSSEANIQLCRIVSHSDLEGEYVLKSFNGAPVPTRNQPSIVFKSVNTNEVEISIVVANRIRGTAALNQNVLSSEEPLMSTRMMGTEEESQLENAFNVGFQYGLETISHGNELTLKNQDCKFVLVKAAAPAAQHGGPTYKGTYCNKCFKTEGNGLLFRIVNEHEKKWAFYNDTEDLRIRVRATFGARSKIEALDNANMYKDDDGRYVVEVTVDPQATEMFIQGDVNGFRVLYDAQPI
Protein: NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL) (Q9BYH8)
Organism: Homo sapiens (Human)
Function: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16513645}. Note=Aggregated in dot-like structures (PubMed:16513645). Colocalizes with NCOR2 (PubMed:16513645). {ECO:0000269|PubMed:16513645}.
Interaction partners:
- Nuclear factor NF-kappa-B p105 subunit
- Transcription factor p65
- Akirin-2
- Signal transducer and activator of transcription 3
- Proto-oncogene c-Rel
- Transcription factor RelB
- Endoribonuclease ZC3H12A
- Nuclear factor NF-kappa-B p100 subunit
- Phospholipase A and acyltransferase 5
- Tumor necrosis factor alpha-induced protein 3
Sequence:
MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAPGSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY
Protein: 5-hydroxytryptamine receptor 3C (5-HT3-C) (5-HT3C) (Serotonin receptor 3C) (Q8WXA8)
Organism: Homo sapiens (Human)
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Subcellular location: Postsynaptic cell membrane {ECO:0000305|PubMed:17392525}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:17392525}; Multi-pass membrane protein {ECO:0000255}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. {ECO:0000269|PubMed:17392525}.
Interaction partners:
- 5-hydroxytryptamine receptor 3D
- 5-hydroxytryptamine receptor 3A
- 5-hydroxytryptamine receptor 3B
- 5-hydroxytryptamine receptor 3E
Sequence:
MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT
Protein: LOB domain-containing protein 17 (ASYMMETRIC LEAVES 2-like protein 15) (AS2-like protein 15) (Q9SLB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Auxin response factor 7
- Auxin response factor 19
- Aberrant root formation protein 4
- WUSCHEL-related homeobox 11
- Transcription factor E2FA
Sequence:
MTGSGSPCGACKFLRRRCVKGCVFAPYFCHEQGASHFAAIHQVFGASNASKLLSHLPMEDRREAATTIYYEAQARRQDPIYGCVSHIFSLQQQVVNLQTQLEILKQQATQSMMAIDSPSIENPNYYQDTKPQYLQESHDLHHHHLTTSNCQTEQNSDLKNIMTSCYHQMEIETTPFTGAGGDTMAGSYYYNSSSGCSEELKSVSTNGEFSKYSELDQHLTNTFNQYRHGGNNLISESLGYITYS
Protein: Uncharacterized protein (D6XFL2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEEGDHMEFSAREIEELENDTINPTNCNHKLDKEHVEKLRQATLQEIEEKDKLVEKGMRLFFMNKVKDAEDIMNNNAPLDPLHALGACCLAALKSLLSMGVNDTKYALQKADFSIAFSTEVATIPKGFFGSVTNLFWGEAGREFQPGMFRAKTIRAQSFAVRGILLISQQGDMMALLRGGMALKNSYKLLQSLKRELEDLKKKKDANSYEGLGADRNSVYGLLLMVGVTHVVISLLPSRVLSILGFLGLKYDRKHGMKFISMTWESRTLFAPFAALFLMVITSFVPGFCPLHVPRWLPAAKAIAEHTVDQPPMGESLLHLWILGRIKRLEQDVEGSMSALSKCLKAAEEGQVAKWMPQLRDFAIYDQGWNFVITMQWREAIELYKRLEDHSAWSKLFYGYAQACCFDMLALEAEQAGNKEGVAKYQQEASEALWRTAHYRINIMGGRAVSVEEFVSVRLGETFKHCGIEHPNKGNKRIVEPTPFPLEGLKLRNPVRVGVIELLALFDITHQMPQSNTEKFLDIIDRVSKKCSDSPQIGSTDDGNGACGNEAPAEKGDEKNIETYTTIVCAAVKANLLCRIESRREEASACLEGAVAISSKYKREKCSVSWVRPQMIYEQAVLASVEGDEGRMNKLLDKVKESNHKRLFQNVMDVKLHLTEYGKEAPVVSHII
Protein: Metastasis-suppressor KiSS-1 (Kisspeptin-1) [Cleaved into: Metastin (Kisspeptin-54); Kisspeptin-14; Kisspeptin-13; Kisspeptin-10] (Q15726)
Organism: Homo sapiens (Human)
Function: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
Subcellular location: Secreted.
Interaction partners:
- KiSS-1 receptor
- Tachykinin-3
- Progonadoliberin-1
- Neuromedin-K receptor
- Uridine 5'-monophosphate synthase
- Gonadotropin-releasing hormone receptor
- Leptin
- Cocaine- and amphetamine-regulated transcript protein
- Prokineticin-2
- Dihydropyrimidine dehydrogenase [NADP
Sequence:
MNSLVSWQLLLFLCATHFGEPLEKVASVGNSRPTGQQLESLGLLAPGEQSLPCTERKPAATARLSRRGTSLSPPPESSGSPQQPGLSAPHSRQIPAPQGAVLVQREKDLPNYNWNSFGLRFGKREAAPGNHGRSAGRG