wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (Q57YD7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQMFLRRDSTHCGTGTSHASSLSPRYRHCCKVPFTFWASVLCIVSSTFLCSSGAASLVLRPNKPLVNVPFSVETTDQSIKADIFVSRMSTCDNTQIIGSKCKISKNAPCNFTVTSNDVGIDPWYDTKVREVYICAGDAFPSLSLSVQLSLVEAIPRYLKRDVDNTIRFGDAVPVGTFITFHRNENCDDVSMIQGLPPAELGSNREVRVTRSVQSVIYLCAKVPTSDGKTFVVPASVLLAVPRYDTNNTDALRHTNETFRLEAVGNLVWATFSQSPLCDPILQDPVGGETLQVVNMEVSVPKGDYFLCNGWPYHKGGRLYSPSENKVTVREYGVQPRTLYSGYGTRIKYTMDAATAAANDVKLVLDFYMYSNCTGAVRVDGPSGIQYRGPPVKKRRSRSDGGAVALPVSGTYYACLEGSTTAYPKARAAVVTVLPPPTVSFDEANVISGLDLTVLLSGHNAGRSGVITVGLSVTPECEELNSKGDVRVGASSVTFRVPEDALPNMTLCVATPSSVDLQADEEPDEGYTYPVKNIATRRYKLKHRTLFVGVAETIHLDANVTLKAGTTGYFSLDNCLTPVGETYSMNATALYGVAFSTAGRHVLCVKTPGTEHPVNRPYSNVGNVMVYGPAELSPASIVKGVSTPVKVSAVPPEAPIVFSESESCTPSISEVNATAEGEASVTVMRNTVGKVYVCVGYHDSDGGAWKVRVSGMLAVSDVEVFPRTVFVGVSNRVNFIVPDKTSLKGLKVLFKETSDVNCGEIVDDGTAVAIRITEVGPAYVVYTAVGMKKWKVCLWKGNGYEDVGLIQSQQQLELVPDSPIGVVGLPLSMRFRGEALTALQPTRFLVSESIESCQSAPGGGIRVYGEGWVDPISGSAEPFVVQKAGELHVCVGWGDTNESYYLYGGKVSAEDFAVDSLYAVRRSTNNFVARPLLKKASLFLVRCVNAASCKVPLNARICEEATERYYTGPTTPLEDVLLGEYALCQQDERRLGVAVGQKPLKVINPFTASFNVSLVRKHTPLRLTLDGGSLHIGASNLTVYIVPPELNCTEANASYDSFPFASGEHSKDVTIVKTPAVAKGARVCVGISAYDKLPASTFNIFHYMTPATIIAGRSVTVESSGIQSGRVRISTLEACTDSILSEYDTVIANSMSTLHVDKCKYRNRDLTDVYYCERGESGGYVMRGTMQLIHLDECPGGKQPAVRPVTALPAKQVTDYGIDKAILTSPFLSTRSDCNGVLSQSRATMTPRYNRNLTFYVCTHTIRDPGYVFTTDGPTLSVENFRVVNPSIHGRVDSDSEVLGPANLVMNYATRTPDTYLSDCAVCGEKIVAAPGLAETPVEEAVTLIGISGVKCVCVLGEQPTSPPIPVAEVLIITPPIVKKIDPAAVPTARFHAKLQTPVVSGAKPLYSLVPGEDAENPLAYLHNSDFRGVYLSENACATTLTGNSVGYVRPSGSVVLGPTFIPGRLPSVSLCVGTPAGNLSVVSEVEVSTDIIFPSSFVLGTEAEVYIPLSPNSAFRLRRDASCGGEDVVPFFTTDEEARGNISFKNVNAAGLPSAGVWTLCQEVFDGSATRPKIVKISANGIAARVASAKQLLPIAQIETFDPTYYNIRGRDVLLGVPGVLYLMDDLYAESLLPGFSTDRSCLRRNESHGSWALVGDDDAASARRVSVTAQNGTDSIYFCATTPVNRSVVSVPLSSSLRFIPPVSVFPSIVEPCKVTPLESCRAPDSSHRQTVVRVIKGDCCNPTDKGVTVGEASEGSDGKCKLRMNHNKIRDYPAGTEFSVCAWDLTDNTYCVTLGNVKASGDICGGSAWGPLGMGAVIAIIVAAVLLFLLLLLLAVCFLRRCCSKEKEERQLVVADKMQLDNLDMSCISGTSPDPEYLESGNNPLLLGFYSGDGSPNTNTTARTMIDGMTSGVDDFAWGGDFPGRADWTSVEEQECDDRDQIALQEARDRYNMALVFTDGIERIRVDAKELELQFDYSGEFSMYEGPTGRGVNVNPIPVTVPADHPDLLNAIYMRRASQRRRLQSQTREEIEVSVHDTMSEMSTDVHDTSRLTSYDMMSYTTTQHFYEESTFMLESEAGRRMRLVNWEEEEWQAIVDAEFSDYVRLQQAMRSIPLPLPQAVVLPFNSTATRGRDTINYSGHTHVDGEGVTVLPVYDTPPFHNPHAASVDEAQAYPNHDEESNVSLSCDSSHN
Protein: Protein-serine/threonine kinase (EC 2.7.11.-) (Q385U0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion matrix {ECO:0000256|RuleBase:RU366032}.
Interaction partners:
- pyruvate dehydrogenase
- Pyruvate dehydrogenase E1 component subunit beta
- Cytochrome c
Sequence:
MFRCYGRKLSPQLRDIIHRLDFIEKQIIDLKAFRDAVQATLPSVATAADALARKRQETANQINVVAKDPLTSEEFVELNQYYAVQMVQTLALRNMVHIRTHEDLYSHARLIHREYLVRVAQRARALSHACVGLSQMPSIQELRRWYEWSFHDVRSTKAPVDAEGALKFDTLVRRLFLRHYNVSALLSEGMHELGERQRWDEHSHSDDLLTETFDELQRFFDEFCMGRVRLRFLVGNYVQLSTQILRVEPRYSEKLTAPMYFDHDPESFVGQICQRCSLIKLVECAIRSARASYSELGIELRVAVDPDATLSGIPYITYDILSALIDDAIQANVLRQEKYGIPFTPVVITIAQRNANEQFSVRVSDTAGGMPLHLARHVLKYWFAYKCTDDMLKLAKTWTHSPIRLPYAYCAAKVLGGDISVVSIDGYGTDRFLHLPSDGIERVRF
Protein: DUF1023 domain-containing protein (P95011)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- ESX-1 secretion system ATPase EccB1
- ESX-1 secretion system protein EccD1
- Putative flavin-containing monoamine oxidase AofH
- Probable PhiRv1 phage protein
- Conserved membrane protein
- propanoyl-CoA C-acyltransferase
- ESX-1 secretion system protein EccCa1
- Possible protease IV SppA
- ESX-1 secretion system protein EccE1
- ESX-1 secretion-associated protein EspK
Sequence:
MLDAVSDARRDGFAVGEDYTVTDRSTGGSRQQRAARLGQAQGHADFIRHRVGALLATDRDIATRVSAATQGLDELAFEDVPGVDTPAEDGVQAVDFRQAPPPGAPGGMSSGDIDAIDAANRALLQDMLAEYSRLPDGQVKTDRLADIAAIQEALRVPDSHLIYVARPDDPADMIPAVTAVGDPFTADHVSVTVPGVSGTTRQTIATMTQETRGLREEARVIAHSVGESENVATIAWVGYQPPPVLASWNTVDDDLAQAGAPKLEAFLRDLQAGSHNPGHTTALFGHSYGSLLSGIALKDGASSLVDNAVLYGSPGFDATSPAKLGMNDHNFFVMTTPDDPIRYPARLAPLHGWGSDGADTIGTVGRQGTPARVGIRPQRDHRRIPGPLPLHPSADRRGIHSAG
Protein: Switch-associated protein 70b (Switching B cell complex subunit SWAP70b) (Q1LYE0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Transmembrane protein 19.
- Calcyphosine 2.
- Plakophilin 3b
- Anoctamin
- Copine 8.
- Copine-8
- Secretion-regulating guanine nucleotide exchange factor
- Fin bud initiation factor a.
- Protein saal1
- General transcription factor IIH subunit 1
Sequence:
MGLRDELLKAIWHAFTALDVDKSGKVSKSQLKVLSHNLCTVMKIPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILDKVQDNFDRIDFNRMCWTLCARKNLNRNHLLISDDDAFKIWCIFNFLSEDKYPLVMVSEEIEYFLRKLTEAMGGSWIEEKFEQYKLQLSSKHQCLKVWELIELVGMGHFSKGMDRQTLSMGITEVFHELILDVLKQGYMMKKGHKRKNWTERWFLLKPSLISYYVSEDLTEKKGDILLDGNCCVESLPDKEGKKCLFYVKCSDKSFEISASDKKKKQEWIQAIQTCITLLKVGRPAPHHEARQKRRELRQKQQAEQEELELRMRELQMANENKQRELEAMRKKLEEAAANAADEERRRLQTQNELQDLYRLEMEKEKMVRQQMEEQVAQKSNELEQYLQRVRELENMYHSLEEALEEERQARQDEETVRKLQARLLEEEVSKRAELEEIHLYQQQTISQTQAEKQELERERLAKESALESAMQQLHQLEADRQGALEQYQEVMKKLSDAANNTKSWKDKVAQHEGLIRLIQPGPKYPQKITNWGPAAFTDAELNLREKDWQEKKNRPATPQ
Protein: pancreatic elastase II (EC 3.4.21.71) (Q6ISP9)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MIRTLLLSTLVAGALSCGVSTYAPDMSRMLGGEEARPNSWPWQVSLQYSSNGQWYHTCGGSLIANSWVLTAAHCISSSGIYRVMLGQHNLYVAESGSLAVSVSKIVVHKDWNSDQVSKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGALPDDLKQGRLLVVDYATCSSSGWWGSTVKTNMICAGGDGAICTCNGDSGGPLNCQASDGRWEVHGIGSLTSVLGCNYYYKPSIFTRVSNYNDWINSVIANN
Protein: T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (P47079)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit zeta
- Phosducin-like protein 2
- Actin
- Prefoldin subunit 3
Sequence:
MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKAGGPRAPQGPRPGNWDQED
Protein: Trafficking protein particle complex subunit BET5 (TRAPP subunit BET5) (Transport protein particle 18 kDa subunit) (Q03630)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.
Subcellular location: Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Preautophagosomal structure.
Interaction partners:
- Trafficking protein particle complex III-specific subunit 85
- Trafficking protein particle complex subunit 33
- TRAPP-associated protein TCA17
- Trafficking protein particle complex subunit 20
- Trafficking protein particle complex II-specific subunit 65
- Trafficking protein particle complex subunit BET3
- Trafficking protein particle complex subunit 31
- GTP-binding protein YPT1
- Trafficking protein particle complex II-specific subunit 120
- Trafficking protein particle complex II-specific subunit 130
Sequence:
MGIYSFWIFDRHCNCIFDREWTLASNSASGTINSKQNEEDAKLLYGMIFSLRSITQKLSKGSVKNDIRSISTGKYRVHTYCTASGLWFVLLSDFKQQSYTQVLQYIYSHIYVKYVSNNLLSPYDFAENENEMRGQGTRKITNRNFISVLESFLAPMVNQ
Protein: Tyrosine-protein phosphatase 3 (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase 3) (P54637)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Seems to dephosphorylate a protein of 130 kDa (p130).
Subcellular location: Cytoplasm.
Interaction partners:
- Signal transducer and activator of transcription C
- Dual specificity protein kinase pyk3
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase roco11
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase qkgA
Sequence:
MISSSMSYRHSTNSVYTLNPHLNIPISTSTTIPPTSFYANNTPEMIQSQSENTNTNNINNSSSNINNNNNNTPDSMSMSTSLSSSPSVSFNHLDLNSINNKINNNTTTNNNNNNNNNNDDKFDTNALKLSNTMIIKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNSNIEINVPSIQFDNEPAMEVDSVAPLNVPSNHTRTTLAMHNTKSLSTSNIGLLNILPNQQSSSSSSLSSTTTTTTTTSSSLLMPQSLFNNSTYNNHHNNNNSSNAGIVGGLNGSTSSLPTQAQVQLQQMQQQMQQHQQHQYKKANLSSLSTVVDNNLNNNPMNTSTSSPAQPNASPFSFSSSSLFSNSSLSNSGSGSASTTSTSTSSSNSMSSSPPPSLKTSFSQLDEDREKMRLEFEMIKKPEMASKKSHKHHQRHYSHNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERFGNDPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTDMGIRSLSSPSKRRSCEMIKSTPMPRLDISIPPPLTFTPKDFQSSISPSTDMIASLSIITQMTQTLKFPPQQQQDNPFSKSSIKISPSPLNSTNISIPKNQQFQHPFQIQPQLDLNLQQQQQQSSQQLNDNPPLNMSSNSIKFPPVTSLSSCHLFEDSKNNDNNNKQQQQQQQQQQKNNQQCSGFSHFLNNNNNNDNNGSSGGGFNGSFLFNSNNSGSSSTNSECSNNNKNNNNNSNNNNNNNNNKNSDNNGTKDKDENDSCESPRVTPIKCF
Protein: E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) (Q8WZ73)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.
Subcellular location: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate-binding and control subcellular localization.
Interaction partners:
- E2 ubiquitin-conjugating enzyme
- Protein UXT
- Cellular tumor antigen p53
- E3 ubiquitin-protein ligase RNF34
Sequence:
MWATCCNWFCLDGQPEEVPPPQGARMQAYSNPGYSSFPSPTGLEPSCKSCGAHFANTARKQTCLDCKKNFCMTCSSQVGNGPRLCLLCQRFRATAFQREELMKMKVKDLRDYLSLHDISTEMCREKEELVLLVLGQQPVISQEDRTRASTLSPDFPEQQAFLTQPHSSMVPPTSPNLPSSSAQATSVPPAQVQENQQANGHVSQDQEEPVYLESVARVPAEDETQSIDSEDSFVPGRRASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKDQKGLQHLVSGAEDQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICRQYVIRAVHVFRS
Protein: Protein LATE FLOWERING (Q9FKA9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a transcriptional repressor. Prevents the photoperiodic and circadian clock-dependent transition to flowering in long days (LD) by repressing the expression of flowering time genes (e.g. FT, GI and CO) in the leaf vasculature, and by interfering with floral meristem identity genes at the apex (e.g. SOC1 and LFY).
Subcellular location: Nucleus {ECO:0000269|PubMed:21771123}.
Interaction partners:
Sequence:
MEDHYHQVEVEGEEEIKPSKEANKTDENTSSLRIFPCLFCSRKFHSSQALGGHQNAHKKERTAARRAKRAYDFVNNNDFLHTLPVFLSSPSQHHLTILGYPASASVACFPTVHPDHPIFKSSGSHVVLATSHQGRDCKGGYCCQQRVDILDHHYNVVNSDKGKDQCLDLSLHL
Protein: Cullin-1a (Q6NYS3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- E3 ubiquitin-protein ligase RBX1
- S-phase kinase-associated protein 1
- S-phase kinase-associated protein 2
- F-box and WD repeat domain-containing 11-B
- Cullin-associated and neddylation-dissociated 1.
- Ubiquitin-like protein NEDD8
- cyclin-dependent kinase
- G1/S-specific cyclin-E1
- NEDD8 ubiquitin-like modifier, like.
- F-box/LRR-repeat protein 15
Sequence:
MSSNRTQTPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQVRGGGPAPSKPSKKTPTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRECLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLSVYKEYFETQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRITDGLGELKKLLETHIYNQGLAAIEKCGESALNDPKMYVQTILDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMVQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYHLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDVYTVQQLTDSTQIKIDILVQVLQILLKSKLLVLEDENANVDEVEFKPDTLIKLFLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA
Protein: Uec1p (A0A1D8PL98)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MPMYVYVVVIICFLPPSFSLKYLPRRTLKLNLLVVVVVLSYIYVYSHISHTFFFFFLIPFNKNFYHQPTQPTTTILVVSKFHSFLQKERRLASQKNFPINHRQRREITTTTTTTTTLILILILYTRRQLIDYTPTKDTITLGNTH
Protein: FI02094p (Rumpel, isoform A) (Rumpel, isoform B) (Q9W3R0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Uncharacterized protein CG1552
- GH02938p
- Seminal fluid protein
- GEO08318p1
Sequence:
MHVEELRASLQSFGWPDYLVFCLMLAICAVIGIYFCLQLRLESRKQKANGSEEAASSAASYLVGGRQMKIFPITMSLISSFISGITLLGTPTEVYLYGAQYMYIMGSLVLMGFCMYYFFLPVFHELNLISTYKYLEQRYNRSLRLFGSVMFIVASLLWLPIVIYVPAIAFNQATGVNIHIVTPIVCVVCIFYTCIGGLKAVVWTDVIQTLIMFGAMALVLIKGTLDIGGPGVVWQKAQETARLEVPNFSADLSERYTFYSLVLGGVAHWLKSNAISQNMIQRYLSLPTLRDARIAIWTFIAGVLAFLMICGYTGLLIYATYSQCDPLETKLAQRNDQLLPLLVMDTLGSYPGLPGVFVAGVFSAALSSLSTGLNSLSAVVLEDFVKTFRKSPLTEGQTAFVMRSVVVVFGIIFVALVFAVEKLGAVLQLTITLSSVANGPLLGIFTAGVMLPWVNSKGALLGGFSSLIVMAWMCVSAQRDLVTGDLVYKRKPYSTMGCNYTFAGEPREFASLALDGAISSVPSAPFQLYRISYLYFTLFGALVTIVVALVTSLLLRETDLDGVDTRLLTPFVRRWLERRRHRRSKIPDSGQKSSNKQETKT
Protein: Parvalbumin (A0A060WYV9)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Protein kinase domain-containing protein
- Guanylate kinase-like domain-containing protein
- Protein kinase domain-containing protein
- Peripheral plasma membrane protein CASK
- Protein kinase domain-containing protein
- Guanylate kinase-like domain-containing protein
- Protein kinase domain-containing protein
- Myosin motor domain-containing protein
- Myosin motor domain-containing protein
- Myosin motor domain-containing protein
Sequence:
MSFAGLNDADVAAALAACTAADSFNHKAFFAKVGLAGKSNDDVKKAFYVIDQDKSGFIEEDELKLFLQNFSASARALTDAETKAFLADGDKDGDGMIGVDEFAAMIKG
Protein: N-acetylneuraminic acid synthase a (Zgc:77126) (Q6P0K4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MPLKFELCPGRMIGGNNPCFIIAEIGQNHQGDIEIAKKMIKMAKDCGADCAKFQKSELEYKFNKKALERPYTSKHSWGKTYGEHKRHLEFSHEQYRELQQYAKQVGIFFTASGMDEMAVEFLHELDVPFFKVGSGDTNNFPYLKKTAQKGRPMVVSSGMQSMETMQHVYKIVKEHNQNFCILQCTSAYPLEPEDVNLRVITEYQKEFPDIPIGYSGHESGINITVGAVALGAKVVERHVTLDKSWKGSDHAASLEPEELAELVRSIRIVERALGTGLKRMLPCEVPCHDKLGKSVVAKTSIPKGTELTLDMLAVKVAEPKGVAPEEIFQLVGKKVTTDVEEDESITEDVVDSYGKKAKA
Protein: DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39) (Q9H1D9)
Organism: Homo sapiens (Human)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus. Acts as nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA).
Subcellular location: Nucleus {ECO:0000269|PubMed:33335104}.
Interaction partners:
- DNA-directed RNA polymerase III subunit RPC3
- DNA-directed RNA polymerases I and III subunit RPAC2
- DNA-directed RNA polymerase III subunit RPC2
- DNA-directed RNA polymerase III subunit RPC10
- DNA-directed RNA polymerase III subunit RPC1
- DNA-directed RNA polymerase III subunit RPC5
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase III subunit RPC9
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC7
Sequence:
MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPMIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPIIPPTGLVRAPCGLCPVFDDCHEGGEISPSNCIYMTEWLEF
Protein: Nucleolar RNA helicase 2-B (EC 3.6.4.13) (DEAD box protein 21-B) (Gu-alpha-B) (Nucleolar RNA helicase Gu-B) (xGu-2) (Nucleolar RNA helicase II-B) (RH II/Gu-B) (Q9DF36)
Organism: Xenopus laevis (African clawed frog)
Function: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (By similarity). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (By similarity). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (Probable). Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (By similarity). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (By similarity). Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12851405}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9NR30}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JIK5}. Mitochondrion {ECO:0000250|UniProtKB:Q9JIK5}.
Interaction partners:
Sequence:
MPGKVYTDEMEGKSIKKKKLTETPLPKLKKRKMQNGETEDLDLEHVTESVNGEINNNNPTPKLKKNKKPAPKSDLSETAEQCDGEQPDPSTPTPKKVKKKKLKEGKEDSDAQEETNISLSSQGGQCDGEQPDPSTPTPKKIKKKKLKEGKEDSDAQEETDISEPQMNGVKSVKKSKKNTTGDEPAPKKRKTDTSEITAANECEEKELTKEEEEIKKEKIDGDFSKFPISKDTIKNLQAKGVTYLFPIQSKTFHTVYSGKDVVVQARTGTGKTFSFGIPLVERLSEDQQPLARGRAPRVIILTPTRELAIQITNELRSMTKKLKVACFYGGTPYQQQVFAIKDGIDFLVGTPGRIRDLVQNYRLDLTALKHVVLDEVDMMFDVGFSEQVEEILSVRYKPDPEENPQTLLFSATCPDWMYNVAKKYMRKQYEKVDLVGHRSQKAAITVEHLAIECNRSQKAAVLGDIVQVYSGSHGKTIIFCDSKLQAHELSTNCGSLKQSAKPLHGDLQQKEREVVLKGFRQGTFEVLIATNVAARGLDIPEVDLVVLYSAPKEADAYVHRSGRTGRAGRTGVCISLYEPWEKHYLRNVERSTGITFKRVGIPSLMNVAKSSSADAIKSLDTVPADVIEHFKEYAQELIEKKGALTALAAALAHISGATSIKQRSLLNMEAGYMTITLKSSVPIHNLSYAWRSIKEQLGEDVDSKIHRMCLLKDSMGVCFDVRSEDLQSMQESWSDTRRWQFTITTELPEIQESERSFDGPRNRSFGGRGRRPFDRRNNSRNSSGGGGGRRGRSGGFRRGR
Protein: FI01909p (Nimrod C4) (Q9V392)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein croquemort
Sequence:
MKFIWALILVLGSIAANAERDNYCERNETIRATVPVTKQRIIVKQPSKWKIWKKTEKITEIYDSEEEQVTHRLVRECCPGYLQVESGLCEPICSRGCPAHASCAAPDRCECISGYVSARNHQDGSHYCEPICETPCPAGAQCVTPNTCACRDGYTQLQPTDDGVSGGCAPVCRVGDGCANGKCIDVDRCACNSGYRWDKAEERCIELSAESISEELETTEDNTDSPSTSSTAVFTATHCPDDFVLFRGECREKQFDSNDVGCLKSGCGPHQTCLDSGVCQCSDGYVPEESGEATGVLSCRRTLLDQILGLNEAIDDDDELNPWTIPIIGVACGFLFVLLIVGLLGGRRYRQERAALANKEMECQYSQKTVDVDEWVP
Protein: SHH signaling and ciliogenesis regulator SDCCAG8 (A0A0C4DG71)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
LLDASEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSDC
Protein: Bloody fingers (Q5J2I5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDPETSIMDQEDLSDLMEESEESEEMSEVEKKRRHVKTPKTSQTKSAQKTFKCPQCGKKFARKSGLTAHVKIHTGEKPFSCKECGKSFSSSGYIKRHMIIHSGEKPHTCDQCGKSFGLASSLKSHAAVHSEEKPFKCDHCGDSFRWLSSLRDHLKTHGKKETHVCSVCGKSFAQLILLKKHKKRHEVKNFMCFECGKTFVRNCELKQHQRVHTGEKPYKCSHCDKRFSNGSSKVVHERIHTGERPYSCDQCGHAFRHTHALESHKRIHTGEKSYTCDQCGKSFTQKASLRIHKKFHNAEKPHTCDQCGKSFTLKTSLNEHMKIHTGEKPHTCDQCGKRFSRLSLLKLHLATHSVIRPYRCEKCGKGFTWESCLKNHLKTHSEEKPHKCSVCGKGFRLANSLRSHQKRHTGVKNHMCFDCGKTYFTKNELKLHQKVHSGGEFYKCLHCDMTFKRLDYVKNHEKTHTVRSDPSESSEED