wanglab/gogpt-training-data huggingface dataset:
Protein: Amino acid transporter, putative (Q381K0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSPRATEPIINEDEHPTLIPSLSQGNVLELPPDSDKSTAAADGEHRGCLNTVFDPIKGVVPSGGMASNVFNLESATLGAGIVMLPSGFLNSGIIIATLMLVYICFTTVYSIRILVITRDKTGFRSYEEMACGLLGRGADYFTAFLMFVFCFGTCVGYVISVGDLLSPLLNQPSTTGFLRTSMGKNVIVGVVWLVAMLPLSLPKEINSLRYASAVGVFFIVFFVICMIVHAAMNGLKDGIGSDIRLVGDGWGILNGFTLFVFAFICQVNCFEVYEEMKGPTPRRMTRDSSVAMSMVGLLYFLSGIFGYLDFGNDLEGSVLKLYKPQDDVMMAIGYVGIAIKICGGFAICIQPSRDAIYYVLGWGKTSDVDSWKNLVVSGVLATLALVLGLVLPSIEVVFNFLGSFCGGFLAFILPALYYMYAGNFSLKEVGWFNYAVTYQLLIVGVFAVVFGTALTIYDEVKK
Protein: N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (Peptidoglycan recognition protein 2) (Peptidoglycan recognition protein long) (PGRP-L) (Q96PD5)
Organism: Homo sapiens (Human)
Function: May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
Subcellular location: Secreted. Membrane.
Interaction partners:
Sequence:
MAQGVLWILLGLLLWSDPGTASLPLLMDSVIQALAELEQKVPAAKTRHTASAWLMSAPNSGPHNRLYHFLLGAWSLNATELDPCPLSPELLGLTKEVARHDVREGKEYGVVLAPDGSTVAVEPLLAGLEAGLQGRRVINLPLDSMAAPWETGDTFPDVVAIAPDVRATSSPGLRDGSPDVTTADIGANTPDATKGCPDVQASLPDAKAKSPPTMVDSLLAVTLAGNLGLTFLRGSQTQSHPDLGTEGCWDQLSAPRTFTLLDPKASLLTMAFLNGALDGVILGDYLSRTPEPRPSLSHLLSQYYGAGVARDPGFRSNFRRQNGAALTSASILAQQVWGTLVLLQRLEPVHLQLQCMSQEQLAQVAANATKEFTEAFLGCPAIHPRCRWGAAPYRGRPKLLQLPLGFLYVHHTYVPAPPCTDFTRCAANMRSMQRYHQDTQGWGDIGYSFVVGSDGYVYEGRGWHWVGAHTLGHNSRGFGVAIVGNYTAALPTEAALRTVRDTLPSCAVRAGLLRPDYALLGHRQLVRTDCPGDALFDLLRTWPHFTATVKPRPARSVSKRSRREPPPRTLPATDLQ
Protein: Uncharacterized urease accessory protein UreF-like (O14016)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probably facilitates nickel incorporation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Uncharacterized urease accessory protein ureG-like
- Uncharacterized urease accessory protein ureD-like
- Urease
- High-affinity nickel transport protein nic1
Sequence:
MTDSQTETHLSLILSDTAFPLSSFSYSYGLESYLSHQQVRDVNAFFNFLPLSLNSVLHTNLPTVKAAWESPQQYSEIEDFFESTQTCTIAQKVSTMQGKSLLNIWTKSLSFFVTSTDVFKYLDEYERRVRSKKALGHFPVVWGVVCRALGLSLERTCYLFLLGHAKSICSAAVRLDVLTSFQYVSTLAHPQTESLLRDSSQLALNMQLEDTAQSWYTLDLWQGRHSLLYSRIFNS
Protein: Probable helicase MAGATAMA 3 (EC 3.6.4.-) (SEN1-like protein) (B6SFA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable helicase that may regulate RNA molecules involved in nucleolar organization and pollen tube guidance.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein SLOW WALKER 2
- DEAD-box ATP-dependent RNA helicase 17
- 110 kDa U5 small nuclear ribonucleoprotein component CLO
- Protein NUCLEOLAR FACTOR 1
- tRNA-splicing endonuclease subunit Sen2-1
- Transcription factor MYB98
- Small ribosomal subunit protein mS75
- Protein SLOW WALKER 1
- Protein GAMETE EXPRESSED 3
- DExH-box ATP-dependent RNA helicase DExH18, mitochondrial
Sequence:
MAIDNGKLQEEEASSVTRFYNIILGWDYKQLTKENERKNRKDSKEKLNVVKNTYKDVDDYFETFEPLLFEEVKAQILQNKDGEEASVCKMRLVMECNEGEGFHFLLVTYEHEEDEYLAQNDLLLLSKEEVKGNSFPSSYGFAVVEHRQNNLLRLRMYLAEDIVQITKNTKSSRTKSFIQALSNMRSLITSSASPIDKRVFSLKLCGLSTIIREYIALRSVSSLPFKDLIFTAAEKSCGFGDEAWKISGPLNEFFNENLNKSQKEAIDVGLSRKSFVLIQGPPGTGKTQTILSILGAIMHATPARVQSKGTDHEVKRGIQMTIQEKYNHWGRASPWILGVNPRDAIMPEDGDDGFFPTSGNELKPEVVNASRKYRLRVLVCAPSNSALDEIVLRLLSSGLRDENAQTYTPKIVRIGLKAHHSVASVSLDHLVAQKRGSAIDKPKQGTTGTDIDSIRTAILEEAAIVFATLSFSGSALLAKSNRGFDVVIIDEAAQAVEPATLIPLATRCKQVFLVGDPKQLPATVISTVAQDSGYGTSMFERLQKAGYPVKMLKTQYRMHPEIRSFPSKQFYEGALEDGSDIEAQTTRDWHKYRCFGPFCFFDIHEGKESQHPGATGSRVNLDEVEFVLLIYHRLVTMYPELKSSSQLAIISPYNYQVKTFKDRFKEMFGTEAEKVVDINTVDGFQGREKDVAIFSCVRANENGQIGFLSNSRRMNVGITRAKSSVLVVGSAATLKSDPLWKNLIESAEQRNRLFKVSKPLNNFFSEENLETMKLTEDMEIPDAPLYEDESLPVAPYGGDDDFGDGDADQDDVAMAGED
Protein: Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) (Q6VUP9)
Organism: Mus musculus (Mouse)
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:16684505}.
Interaction partners:
Sequence:
MLVHTYSAMERPDGLGAAAGGTRLSSLPQAAYGPAPPLCHTPAASATADYHPPYFPPPYPQAPLPYGQGPDATAAFPHLAADPYGGLAPLAQPQPPQAAWAAPRAAARAHDEPPGLLAPPARALGLDPRRDYAAAVPRLLHSLADGAHGLADAPLGLPGLAEPPGLEELQAIDDPGMSLLDQSVIKKVPIPSKAGSLSTLALSKDSLVGGISNPSEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLCRQHADPGELHSRKSMLLAAKQICKEFADLMAQDRSPLGNSRPALILEPGVQSCLTHFSLITHGFGGPAICAALTAFQNYLLESLKGLEKMFLSGAGGGHGESKASEKDTKHRK
Protein: Nodulation outer protein NopA of type III secretion pilus subunit (C4ALD0)
Organism: Sinorhizobium fredii (strain NBRC 101917 / NGR234)
Interaction partners:
Sequence:
MSKIGTLTSAVGAGAAAGQNVAAKGAGAAAFQAQIAELAAVSAEATARSMLLRTVTTELQTTKKAADERVQ
Protein: ORF008 ankyrin repeat protein (Q6TVW2)
Organism: Orf virus (strain Goat/Texas/SA00/2000) (OV-SA00) (Orf virus-San Angelo 2000)
Interaction partners:
Sequence:
MSEKGFPTFVNAAAMLSRESVVAPHADLLFRYLESGQVDLATVRALVATDADVNFRGEYGRTPLHLCVHFARHEQCAEIVRVLLEAGADVNAKDTCGFTPLHAYVQHDCVRPEVVALMLEAGADVVCDDSFVFYDSALSSFLSSCGSDGTELEVARLLLDAGARVNEGDTYGMTPLHVYAKNQWIREDVLRLLLERGANPNACDCHGVTPLAALLGSGGVSAALVDVMLRAGADARAVDAYRRTTLHHLARTAKISEGLVRMLTGLGVDPAAVDASGNTMLHYMATYGRCARGVVEFVLERGLDLNLRNNNLQTALHRAAVFSHGACCRLVRMGAELGHVAASGLCAVSEMLRRNNVRATAAVLARRPPTELLVRALLTSERWGHVFKRSEAALLCVQELALRGEGARLLAERALADYATVVRACEQEIASMRAVRCHTDATLLDVLRAAHDAKALFVSNAFLERAAEFPIYGTALFGKVCMMRLRVSLAEQIAGLMCPCALPPEIVTSILCFLPYESLLDLRRAMLTRP
Protein: Uncharacterized protein (Q385Y5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEKIVRTVYKQLYKKASQVEKDVAMRTALTCSPRRVYDHRCGKWVPMDVAKLSGWHETRVFVDALVRRLNGGREFFIPLANNGGGDANNTGMEAKSPSMVDILRQSFESTPFTSTQIGNAFAALRELANVTDTAVKYSNSVAPPPEEVRSVPTPKLTVVSAVEGMHHLSLTRGLSEVLEGVPYEDMGVSRTSEEDVHTEGKAETKDTSSEEGVISEEESDDRSSNKKATFDTPKKAQLLLAHPQLYDFFRYTVMIVVRVTPNESAALVLNKPLENDKGALMPVSMTMRLSSAHPLFAKHLCNHTVMIGGPVSRGSFDSTMLLLHRIPDVDDAIPLSHSLWIDGSYDTLQQKIEDGTADPKDIVVICGFSGWGVQQLEGELQSGTWVAASGSTDDPALDNFVFTIARLAGTHGPSPVASDPSPTGEGNEAPSATSMEERNRWRRASLWAWAYSALGQPFASMAGNQKPFMHAPPDA
Protein: Musculoskeletal embryonic nuclear protein 1 (E7F422)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Si:dkey-26i13.8
- Si:dkey-165a24.9
- Beta-galactosidase
- Phospholipid scramblase
- Homeobox protein Hox-C6b
- Homeo box C12a
- Mahogunin, ring finger 1b.
- Prepro-urotensin II-beta
- Urotensin 2, alpha
- Homeobox protein Hox-C12b
Sequence:
MSQLGEQEEVKRPEVKTEDLIGARDKLASGTEVKSKTFEVMQECERAGKAAPSVFSNVRSGSETAFNKPTKRK
Protein: MORN repeat-containing protein (Q4GZ27)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLPSSQDQLPSEKTSRTTADAVRRVAAYPIDFNTAQSSTITHQQQQQLKSCAGIDLNLHPLCQQHFYTGEMMRGGEGSRGALIPHGKGTLLWVLYATAPDISFTDPSGSVGLPYELLVREFGEVNTLRDAVLLALCVYSGSFNSGKKWGGGSLTIYPQCVKLDCCWEDGKPMLKRNYCVLYYPASSQAASCGDSAGSNSGRSGGSSDSTASLGTLLRSGLTRAGKAATASTANHQYIGMLTMTTVAGKAQCSLTAGLAWSQHVQFMPDGIGEMCYQGGVRYCGEWKSGRQHGFGVEFDPNGFGSMVYIGRFENNRRCGTGTLYNCKAGVVVSGTWSEGKLCSAVDVGLPSWPFVLRNAQWTNVDEWSFEKASLVHSDTSLNGTWEPLFSDFDSALTDPADLEKEEMLLQKGTNGGRDSDADGGADEWERSSVIMLLRSFLQRTELKATLMLFQRCFYFLYKPCAGGARWLDAEMLTPLRKSKQQQNDGEPATVGSSGASLPVFAKLRDLGRTDCGISFFSDRGRHWCAPSWCNEMGLGSGGGNSTGGDGYVGYGCFHTASTAEGLAARLPPEALFKWAARDLAFVVSSVRLRLLSCIASHPAAGSLVGSRHVLAVCWDTVYSLVAPVMHDLASAVEIKAYLETSMALKRCINLCPSGFVCSTHLSEASSAAVSNDEIQGVIRRCGFVFSSPSRHWRRRATETNNGKLLQFGPYVSNEIDCTSEEAVTYATPSTLLAAFATLRCYADRLFPRNELLRERWMSGSIANAFTKAAEVHPQLAMSPPAVLRVLATLATEVNPAYPFAMEDVLGIDEQRGVTLSSTRIDSGDRDASITDVMSLLLAAHESAVRLRHAYPNIRHVVSYVVSSGSGTHNAHRFDAVYPLDELAVRTRFVLLGVAAEVVQQQHMWFGRLVSRDNVRSGNGECNNSYLYCSDEDVAHPQVMSNDASGDELAQMKERAERVLRLPVWVMQEQISKRCADQHTPVGKGERKLQTQTPSTEVLRWVMKCVGSILELPNVSKVQGQSTQQAKASRQRSLDSSVRVTQDLWQADPVLAVSSECNDEDCGRRESLSDSGLLGQSFKWKHFLPSIPPFTVAAADARRHTVAVELAATQFITGTQPDALLTSGEILNFALIQKLLADVGVTAKLCMRFCYDNEEDSLFSPQLGATRGNGEDLTLSFNSLNAAANEEESDTPASVSCVGREAEFTLHMGSDFIGSLCWDVLADAWMAALTSLRTETMDVQRLAKLTVVRQSDTGDV
Protein: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) (Q8N1G2)
Organism: Homo sapiens (Human)
Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:21310715}.
Interaction partners:
- E3 ubiquitin-protein ligase RNF8
- ATP-dependent RNA helicase DHX15
- mRNA-capping enzyme
- DNA polymerase subunit gamma-1
- Activating molecule in BECN1-regulated autophagy protein 1
- Histone lysine demethylase PHF8
- mRNA cap guanine-N
Sequence:
MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQKFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAPFHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA
Protein: F-box only protein 48 (F-box protein 48) (Q5FWF7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MHKNSKRNNNLRVSHTEANSVDAEKEKNESQNNFFELLPAEITFKIFSQLDIRSLCRASLTCRSWNDTIRNSDSLWKPHCMTVRAVCRREIDDDLESGYSWRVILLRNYQKSKVKHEWLSGRYSNICSPISLPEKIMYPMDADTWGEILEAELER
Protein: Zgc:136962 (c-Myc-binding protein) (Q24JV0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAHYRASESKREQFRRYLEKAGVLDSLTNVLVALYEETEKPNNALDFIKHHLGVSGVEAEDAESLREELNTLQQKHQQLMEENQELKSRLLQYEPPQDEAAAVE
Protein: Roundabout guidance receptor 2 (A0A8I6AKD6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTPLMFTLLLLFGFLCIRTDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGTYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDEKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEDEPAEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKAISADEGTYVCIAENRVGKVEASATLTVRVRPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPINQTLAVDGTALLKCKATGEPLPVISWLKEGFTFLGRDPRATIQDQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDTNDLPGPPSKPQVTDVTKNSVTLSWQPGTPGVLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVTVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQASTVWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTIRTTEEAPSAPPQSVTVLTVGSHNSTSISVSWDPPPADHQNGIIQEYKIWCLGNETRFHINKTVDATIRSVVIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGGRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNTGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTTYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSVQQKSDLMGFAYSLPDQNKGNNGGKGGKKKKTKNSSKAQKNNGSTWANVPLPPPPVQPLPGTELGHYPAEQENGYDSDSWCPPLPVQTYLHQGMEDELEEDEDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNTPPPQPPVPPLGYASGALISDLETDVPDEDADDEEEPLEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRQRPTSPFSTDSNTSAAQNQSQRPRPTKKHKGGRMDPQPVLPHRREGMPDEESLVPYSKPSFPSPGGHSSSGTASSKGSTGPRKAEILRGSHQRNANDLLDIGYVGSNSQGQFTGEL
Protein: Major facilitator superfamily (MFS) profile domain-containing protein (Q9U2R3)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MKEKGSTLVPFLADRQRYIILAIGTLCIAAIASNMTVINFTMICMAKPVNSSALTSNVEADNLAYSNKQKSIIMWAAAVGTLAAAWPFHWFYTQFGARSVFFAAGVVSTLSTAVMPLAAEVHFNFLVVARFFQGVSFGADFAAIGLIVVNWASLKQHGLFISLLSSFSQISVMFTMPVAGELCESTWGWQSVYYVHAVLSGVLFTAWLYFYRDNPTKHPQMTEIELEKIHRGKGDVKEHEKAPIAKILTNSVMLAVWLSAFGELMMSQFIVMYGPTFLKEVLGFAVNHTGYFVAVPRALHLAFKIISGVASDRIQFWSEKTKMRIFNTIALMVSGAFFCILGYLPKEQAHLSLVALLVIECSTGFICGGFYKCATLVARQHSHFVLSQIQFIKCLSLFIEPLLVFLICSHNTLEEWRIVFLTHGILLIVGNIIFCYFATDEPADFTRSATGEEMTDVPPERRRLTENEA
Protein: Myosin heavy chain 10 (G3V9Y1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQESPKPVKPQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIPIPGQQDKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVDRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVLLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDELKVQLTKKEEELQGALARGDDETLHKNNALKVARELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGMKFAKDAAGLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIEGLEEAKKKLLKDVEALSQRLEEKVLAYDKLEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHIEGASLELSDDDTESKTSDVNETQPPQSE
Protein: Barrier-to-autointegration factor (LAP2-binding protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed] (Q9R1T1)
Organism: Rattus norvegicus (Rat)
Function: Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA. Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging. Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner. Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface. Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity. Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses. Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1. Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O75531}. Chromosome {ECO:0000250|UniProtKB:O75531}. Nucleus envelope {ECO:0000250|UniProtKB:O75531}. Cytoplasm {ECO:0000250|UniProtKB:O75531}. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. The phosphorylated form (by VRK1) shows a cytoplasmic localization whereas the unphosphorylated form locates almost exclusively in the nucleus. May be included in HIV-1 virions via its interaction with viral GAG polyprotein. {ECO:0000250|UniProtKB:O75531}.
Interaction partners:
- Emerin
- Prelamin-A/C
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Lamin-B1
- Inner nuclear membrane protein Man1
- Serine/threonine-protein kinase VRK1
- Paired box protein Pax-6
- Ankyrin repeat and LEM domain-containing protein 2
- Delta
- Lamin B2
Sequence:
MTTSQKHRDFVAEPMGEKPVGSLAGIGDALGKRLEERGFDKAYVVLGQFLVLKKDEDLFREWLKDTCGANAKQSRDCFGCLREWCDAFL
Protein: Galactokinase (EC 2.7.1.6) (Galactose kinase) (Q9SEE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sugar-1-kinase with a very high substrate specificity for the alpha-anomeric configuration of D-galacose (D-Gal). Converts also efficiently 2-deoxy-D-Gal to 2-deoxy-D-al-1-phosphate.
Interaction partners:
- ADP-glucose phosphorylase
- Thylakoid lumenal P17.1 protein
- UDP-sugar pyrophosphorylase
- Bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 3
- Bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 1
- UDP-glucose 4-epimerase
- UDP-glucose 4-epimerase 5
- UDP-glucose 4-epimerase 2
- UDP-glucose 4-epimerase 4
- Aldose 1-epimerase
Sequence:
MAKPEEVSVPIFTSLEPVYGEGSLLQEATQRFDVLKANFNDVFGASPQLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIIAIRKCEDQKQLRIANVNDKYTMCTYPADPDQEIDLKNHKWGHYFICAYKGFHEYAKSKGVNLGSPVGLDVLVDGIVPTGSGLSSSAAFVCSATIAIMAVFGHNFEKKELAQLTCECERHIGTQSGGMDQAISIMAKTGFAELIDFNPVRATDVKLPDGGSFVIAHSLAESQKAVTAAKNYNNRVVECRLASIILGVKLGMEPKEAISKVKTLSDVEGLCVSFAGDRGSSDPLLAVKEYLKEEPYTAEEIEKILEEKLPSIVNNDPTSLAVLNAATHFKLHQRAAHVYSEARRVHGFKDTVNSNLSDEEKLKKLGDLMNESHYSCSVLYECSCPELEELVQVCKENGALGARLTGAGWGGCAVALVKEFDVTQFIPAVKEKYYKKRVEKGVVKKEDMELYLFASKPSSGAAIFNL
Protein: RbAp48-related WD40 repeat-containing protein prw1 (O14021)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones.
Subcellular location: Nucleus {ECO:0000269|PubMed:12773392}.
Interaction partners:
- Chromatin modification-related protein eaf3
- Histone deacetylase clr6
- Uncharacterized protein C2F7.07c
- Paired amphipathic helix protein pst2
- Transcriptional regulatory protein sds3
- Uncharacterized protein C16C9.05
- Chromatin modification-related protein png2
- Histone deacetylase phd1
- Paired amphipathic helix protein pst1
- Paired amphipathic helix protein pst3
Sequence:
MAVSAVPHPSKQAQASEEGINQEKCINEEYKIWKKNSPFLYDLIITRALEWPCMSLQWYPEQQIFAEHGYTEQKMFLGVRADVGKYLLAVASIQLPYLNQTVPPTTMEGASAGDESSLRVNISNLYSHPESVCSAKLMPQDDSCVATVGNYHNDVLVFDKESFESYSSASESPLKPKYRLTKHTQPCTSVCWNFLSKGTLVSGSQDATLSCWDLNAYNESDSASVLKVHISSHEKQVSDVRFHYKHQDLLASVSYDQYLHVHDIRRPDASTKPARSVHAHSGPIHSVAFNPHNDFILATCSTDKTIALWDLRNLNQRLHTLEGHEDIVTKISFSPHEEPILASTSADRRTLVWDLSRIGEDQPAEEAQDGPPELLFMHGGHTSCTIDMDWCPNYNWTMATAAEDNILQIWTPSRSIWGNEQLEEDATAYLS
Protein: GH04850p (Q8MRQ6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPPGLSRSSRWPCLPMVQSPLVISAMAWILHRTLEEPFSDWPTRCLPLVASFPRRWWEPSPTRINPSIRGKLCSGSWPPPISRQLWCSPSLAAVNCSRGTILQNVSESATSPRGRVCPSRTRSDCTSPVRLIRCHCCS
Protein: Arabinosyltransferase RRA3 (EC 2.4.2.-) (Protein REDUCED RESIDUAL ARABINOSE 3) (Q9LN62)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in the arabinosylation of cell wall components. Involved in the arabinosylation of extensin proteins in root hair cells. Extensins are structural glycoproteins present in cell walls and its arabinosylation is important for root hair cell development and root hair tip growth.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:21680836}; Single-pass type II membrane protein {ECO:0000305|PubMed:21680836}.
Interaction partners:
- Hydroxyproline O-arabinosyltransferase 3
- Hydroxyproline O-arabinosyltransferase 1
- Arabinosyltransferase RRA1
- Arabinosyltransferase RRA2
- Hydroxyproline O-arabinosyltransferase 2
- Prolyl 4-hydroxylase 5
- Peptidyl serine alpha-galactosyltransferase
- Prolyl 4-hydroxylase 2
- Protein trichome birefringence-like 13
- Prolyl 4-hydroxylase 13
Sequence:
MAGRRDRSQQLRGSRIAIAILIGIFIGCVCAVLFPYGFFNSSSSLKASEHLSKSSNQVGSSACESPERVKMLKSDFVTLSEKNAELKKQVRELTEKLRLAEQGSDNARKQVLALGTQIKAGPFGTVKSLRTNPTILPDESINPRLAKILEEIAVDKEVIVALANANVKAMLEVQIASIKRVGITNYLVVALDDYIENLCKENDVAYYKRDPDKDVDTVGKTGGNHAVSGLKFRVLREFLQLGYGVLLSDVDIVFLQNPFSHLYRDSDVESMSDGHDNHTAYGFNDVFDEPAMGWARYAHTMRIWVFNSGFFYLRPTIPSIELLDRVADRLSKAKVWDQAVFNEELFYPSHPEYTALHASKRVMDMYEFMNSKVLFKTVRKNHELKKKVKPVIVHVNYHPDKLNRMQAVVEFYVNGKQDALDSFPDGSE
Protein: Suppressor of activated egl-4 protein 1 (Q20733)
Organism: Caenorhabditis elegans
Function: As a likely component of a histone deacetylase complex, together with saeg-2 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging.
Subcellular location: Nucleus {ECO:0000269|PubMed:21573134}.
Interaction partners:
- Suppressor of activated egl-4 protein 2
- UPF0375 protein C08F11.12
- Putative histone deacetylase 2
- UPF0375 protein Y45F10C.2
Sequence:
MPPPQHPPNYYAPRRSISTITGPNRRDVDAFYQNNFPEKNGGSSGEHVPEYQASGQQHRPSIMSGQSHQNNHLPTKNYSYEPLRFSPPNVTPPPLQFSTNTDGNRKNQRVRFNELPNYSTPNHYSVPPRKCSLAPNFFSSQNSHHMYPDQYTPRTWQNNEFMPNHQVHPYHANHQQQHPQQHWRNQAASNGNHNPMYMRKHSAGHGIEIKLDHVDNPFGNPSHDMMDVTSGQPVKSEMLSPIKMETTDPSQQIASPSFLMTSTSLLKQHLHKKSHHNVPSRKASIMALKSQLRTPRGTPLNISTVPGTELPYTPPPILAPMRNGSGLFCQIVKSANSSLPVAEQSPDAPSCSTNGVDGDMKHLMNGKKRSEDGDGPSRKNGFFYMAQQMNQTNFANELEALRKESWASTSSADEKMQTERKESLESIRKASCMSDSYYEIEEGPKISDPNPHINLGKNYQARVKKWCDRQVSTSERDAIEDRDEIVFSSEILQDIDPEQITAFELLACSQACPRAGRNKELALHLLMENKGNIEAAVEDLLRSDTLDWEHYSSVFGYMYNDSVLWTPDEIYQFQDAIYQSEKDFDKVAVELPGKSVKECVQFYYTWKKDCPDDYRKLRNLRRKRQLLDINLQKNQSEEPVVPAKKISIIESGDSDNESNATDSSFIGNGHMEFRDRAFTSPMMSSPREEPIIGLSPSSKDLFGIQKNYQPTAPRAHHTPSASASKKGAQPSADGFFHCRLCDKCFEKVKSLNAHMKSHAMKARAEQEAKAHDAQVAAAAAAQLTSAVGNVVGNPVATSPLNSFANGHLGISIPSTIGNLTPQQLTPQQLNLNQQLQTQLNSLSNQMSLNSPLTPQQQLQQFTQQHLMARAMQQNLFQPVTSTPLVQPTHPLIQAGLHSIN
Protein: UDP-glucosyltransferase 74AE2 (PgUGT74AE2) (EC 2.4.1.364) (UDP-glucosyltransferase 74A1) (PgUGT74A1) (A0A0A6ZFR4)
Organism: Panax ginseng (Korean ginseng)
Function: Component of the dammarane-type triterpene saponins (e.g. PPD-type ginsenosides or panaxosides) biosynthetic pathway. Glycosyltransferase that catalyzes the biosynthesis of ginsenoside Rh2 from protopanaxadiol (PPD) and the conversion of compound K to ginsenoside F2.
Interaction partners:
Sequence:
MLSKTHIMFIPFPAQGHMSPMMQFAKRLAWKGVRITIVLPAQIRDSMQITNSLINTECISFDFDKDDGMPYSMQAYMGVVKLKVTNKLSDLLEKQKTNGYPVNLLVVDSLYPSRVEMCHQLGVKGAPFFTHSCAVGAIYYNAHLGKLKIPPEEGLTSVSLPSIPLLGRDDLPIIRTGTFPDLFEHLGNQFSDLDKADWIFFNTFDKLENEEAKWLSSQWPITSIGPLIPSMYLDKQLPNDKGNGINLYKADVGSCIKWLDAKDPGSVVYASFGSVKHNFGDDYMDEVAWGLLHSKYNFIWVVIEPERTKLSSDFLAEAEEKGLIVSWCPQLEVLSHKSIGSFMTHCGWNSTVEALSLGVPMVAVPQQFDQPVNAKYIVDVWQIGVRVPIGEDGVVLRGEVANCIKDVMEGEIGDELRGNALKWKGLAVEAMEKGGSSDKNIDEFISKLVSS