wanglab/gogpt-training-data huggingface dataset:
Protein: Vam6/Vps39-like protein (Q8R5L3)
Organism: Mus musculus (Mouse)
Function: May play a role in clustering and fusion of late endosomes and lysosomes (By similarity). Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96JC1}. Lysosome membrane {ECO:0000250|UniProtKB:Q96JC1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96JC1}. Late endosome membrane {ECO:0000250|UniProtKB:Q96JC1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96JC1}. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles. {ECO:0000250|UniProtKB:Q96JC1}.
Interaction partners:
- Vacuolar protein sorting-associated protein 41 homolog
- Vacuolar protein sorting-associated protein 33A
- Vacuolar protein sorting-associated protein 18 homolog
- Vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 11 homolog
- Syntaxin-17
- Vacuolar fusion protein CCZ1 homolog
- Vesicle-associated membrane protein 8
- Vacuolar protein sorting-associated protein 8 homolog
- Transforming growth factor-beta receptor-associated protein 1
Sequence:
MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCVAVRKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIVAVLPRYVEIRTLEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPTLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLNFLIENFKALAIPYLEHIIHVWEETGSQFHNCLIQLYCEKVQSLMKDYLLSLPTGKSPVPAGEEGGELGEYRQKLLMFLEISSHYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTKMAKEYCHKHYDQNKEGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPQANLQAALQVLELHYSKLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNSADT
Protein: Heat shock protein 40, type II (Q8I2E1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Heat shock 70 kDa protein
- Heat shock 70 kDa protein
- Endoplasmic reticulum chaperone GRP170
- Heat shock protein 110
- Heat shock protein 70
- Endoplasmic reticulum chaperone BIP
- HSP40, subfamily A
- Heat shock protein 90
- Heat shock protein 90, putative
- Endoplasmin, putative
Sequence:
MATLRKSYVPEILYFSKFFMNACFISLLIITVNCFNYENFVCKDKGIYNEKIVIRYKRCLAEGNKNFFFNKDNGVFGKSSMDYYTLLGVDKGCSEDDLRRAYLKLAMKWHPDKHVNKGSKVEAEEKFKNICEAYSVLSDNEKRVKYDLFGMDALKQSGFNSSNFQGNISINPLEVFTKAYSFYNKYFSKSSGAGNHNIFTHIKNLYPLRNDFSEDESSYNDVEEYEVPLYVTLEDLYNGCTKTLKVTRKRYDGCYLYYEDYFINVDIKQGWNNGTKITFHGEGDQSSPDSYPGDLVLVLQTKKHSKFVRKSRDLYYRHIITLEQSLTGFDFVIKSLDNRDIHIQIDEVVKPDTKKVIKNEGMPYSRDPSIRGNLIVEFDIIYPNTIKKEQKKLIKEIFKESY
Protein: PHD finger protein 24 (Q80TL4)
Organism: Mus musculus (Mouse)
Interaction partners:
- Chemokine-like protein TAFA-4
Sequence:
MGVLMSKRQTVEQVQKVSLAVSAFKDGLRDRPSIRRGGELPGSRRGTVEGSVQEVQEEKEAEASAPVVQEESSINRAAWERLRDGRGVEPEEFDRTSRFTPPAFIRPTRKLDDDKPPDICLEPREPVVNDEMCDVCEVWTAESLFPCRVCTRVFHDGCLRRMGYLQGDSAVEVTEMAHTETGWSCYYCDNLNLLLTEEEMYSLTETFQRCKVIPDCSLTLEDFVRYRHQAAKRGESSRALTDEQEEQAARQFAALDPEQRGHVEWSDFLSHESLLLLLQLRPQNSLLRLLTVKERERARATFLARGRGSTISEAECHHARHSWFCKRLTEAPSCSVSISHVGPIADSSPAASSSKSQEKALLPTEQESRYVDWPTFLRENVIYILAARPNSGAIHLKPPG
Protein: Grip163 (Q9VTS3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
- Gamma-tubulin complex component 3
- Gamma-tubulin complex component 4 homolog
- Gamma-tubulin complex component
- Gamma-tubulin complex component 2 homolog
- Tubulin gamma-1 chain
- Tubulin gamma-2 chain
- Grip71
- GEO02508p1
- Testis-specific gamma-tubulin ring protein 91
- Testis-specific gamma-tubulin ring protein 128
Sequence:
MATVAECNHSVLDLVTKMATMLVADEMKPKKQTAVLVAKKRSKIYESLLHSETMSSQDKLEMLHQVTSEVAKNPDRMDMLLRFQNLLEGQDKEESEITQDQDEENQSEVVIKRIKAGPLQLIETIEIVEEALHPKAFPDINQMNRALKPLQLQPYSDILTTSNLNINFPPEKLIPKIIPSTVIRMGLSESITRMRNEMEKPMHPPPRLPVLAKKVVAPLEDERPFVAQPGPEKHFVSDKLLTNELKILRNKNLVLNYLDEATLIDHLKKAACGIESLTFPISSADKLELRVRPNTTLPTMLPEVLADFANHFIRAGCAFLRLSSRTKWNNIAEMRLERPLNRAMRETIMDYLSTTRQFLLSLQADSLFQLLNNTSTAIQLLCQLDRMFENEPRLNLNTGITGSFLLSSIWLAIDTCGNKDFLHLLIYFLRCISRNYFIQLQRWIYHGELDESVNEIFISRCLNTSPSFTNQCSKEFFDKSYQVDNEAIPEFLVGCEEEILQCGKYNLVLRAYNAQHPVFDVQYPDIVVCLTEQQLKNMRRNLADKYAIIYKRFGWCSMQSIFEDRMATKRVFANLMVKRTQAHLDAWAQKQRELQIKANAQKKLQNDQLNAEQERIQQNHLEKRRQDIVNELAFQRECERMEDKLLEREKQELQKKVVQLAAVLSSSPDRSTVSDLSFASCIEEPDCLAESSSDKDDANTENSEDEATKQLDKTLNVPLEQPEAEYQADVDVDQPRGKECSLPNVFQYQRSHSDVINSNEHPTTQAEFNRNRQHGLSSDQFQQCHATVHLQESDLLKTAASTSSGLHAEIPQDINANLNCPDTKELTELQRNRKRNEHHDGFFSFNSTEDEHTHRLRSLLNSNTERGRNRLRVMETEFGLGYKNTDIETKATPCLPLEIDKLHVEIPLAVLTPMSTTSDVDFGDPSPRELPEIADTANNNNVSGSIESLSPELPKPVLAIAKPTSLLPKLDFGMKDERETEQDRDKVSTLPEACNPFMARRCLQLSVMAPLNAYYGLLRNEVLRIFQEQRIYEHFRKLRNYFFLVDGQFGATLTNEILGRIRAGVGPRSLSQKGILDTILTNALAACSADETTVSENLTLNCTTIPDTLNFLSVEATSMLKLNCKIDWPLNMVISSETISKYGQIFGYLLKLRHVSFVLDGTYEYLQQMGKLLGPELRTCTHFRHMQMMRHKMSHFMTSFQTHLVAKALLSTWKSFKEELCTADSIEALYKQHVAYLKRVAFLALLNRRSAKVKETIDNILVIILRFCKVIQSQSFIVDQDNYFVHPRFKRLQQEEAEFEKFLQYLIYLGNKAAASGYQEEIGDLICIINFNHYYKVSGNHTGSSMEDKKC
Protein: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase (EC 2.4.1.155) (GlcNAc-TV) (Glycosylation-related protein 2) (N-acetylglucosaminyltransferase gly-2) (Q9NDH7)
Organism: Caenorhabditis elegans
Function: Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Exostosin-like-3 homolog
- Alpha-
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- beta-N-acetylhexosaminidase
- Alpha-
- GLOBIN domain-containing protein
- Globin domain-containing protein
- Globin domain-containing protein
- Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Sequence:
MRRRHRCVALLFIFSAFITPLGFFYYTISNESKRYSEESEKNYGYQTLEFTESPEEISVDFDKYSQSECSRFPSNVEIEYPECLNKMKWIKNGWKTHHCYIENHIDGSECSFRYYLSQVENYCPPMEHHGKRKGLAKISPSIRRLLPIFESIPHYMKTRINRLWKKWKEGAHEVMQKYPKSMIERRKLNVLVFIGFLANEQKLNMAKKSDHGGPLGELLQWSDLLATLSVIGHHLEVSTNKNTLRNIVWKYMSRGPCQYVNNFRQQLDIIFTDIMGFNILRQHHRQFLLSNRCRIRLLDSFGTHAEFTTKTYFVQNKKSLSGPFSQRNPWGGHGLDLRQHWTFYPHSDDNTFLGFVVDTEGIDKKNNQMIPSALVYGKEQYMWRDAEKPIDVLKRIVTVHSTVADLDLKDSNISSIFKKVQNHGFLNSEEISQLLDNITIFFGLGFPLEGPAPLEAMAHGAVFINAKFKEPKSRLNYKFLAEKPTLRKWTSQNPYMEKIGEPHVITVDIFNELELEEAIKRAISLKPKHFVPFEFTPAGMLHRVALLLEKQELCDKIAYSKRWPPIDQMKIFRTLNADDSCETICHSKQLLCEPSYFPIINSSPLLRRENLCSSTTSDSSPFAPFNCTIQQSAFLFSCASSPPISFEINRLCPCRDYIPEQHAICKKCL
Protein: Sp1, isoform B (Q8IRM5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMGGAGMHSTMANYASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAAAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKGSSESCSDSEEAANQSGESNGLGGVGSGPQTGGAGGGGGGSSSGNGAGTLAVSGSVTTGAGAGSGTGSSNSNSNSGGSSGSVSGSVSGSGSHPGTPTSLHAHSANGTSSSLLGGGLHLATPHQMVAAGGSPVMLHQQQQQQQHQQQQQQQQQQQHQQQQQQQHQQQQQQHQQQQQQHHQQQQQHHHQQFGQQQHPHAHHLHHHAHHAHHLATGGSPGLDPSSLVDIKPPMV
Protein: Terminase, large subunit (DNA-packaging protein gp2) [Includes: Endonuclease (EC 3.1.21.-); ATPase (EC 3.6.4.-)] (P26745)
Organism: Salmonella phage P22 (Bacteriophage P22)
Function: The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities (Probable). Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. Once the capsid is packaged with the DNA (headful packaging), the terminase cleaves the viral genome concatemer and is substituted by the tail (Probable).
Interaction partners:
Sequence:
MELDAILDNLSDEEQIELLELLEEEENYRNTHLLYEFAPYSKQREFIDAGHDYPERCFMAGNQLGKSFTGAAEVAFHLTGRYPGTKGYPADGKYGGEWKGKRFYEPVVFWIGGETNETVTKTTQRILCGRIEENDEPGYGSIPKEDIISWKKSPFFPNLVDHLLVKHHTADGVEDGISICYFKPYSQGRARWQGDTIHGVWFDEEPPYSIYGEGLTRTNKYGQFSILTFTPLMGMSDVVTKFLKNPSKSQKVVNMTIYDAEHYTDEQKEQIIASYPEHEREARARGIPTMGSGRIFQIPEETIKCQPFECPDHFYVIDAQDFGWNHPQAHIQLWWDKDADVFYLARVWKKSENTAVQAWGAVKSWANKIPVAWPHDGHQHEKGGGEQLKTQYADAGFSMLPDHATFPDGGNSVESGISELRDLMLEGRFKVFNTCEPFFEEFRLYHRDENGKIVKTNDDVLDATRYGYMMRRFARMMRDIRKPKEKKIPAPIRPVRRGR
Protein: Uncharacterized WD repeat-containing protein C227.12 (Q9UTC7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-processing factor 31
- U4/U5/U6 small nuclear ribonucleoprotein prp3
- Pre-mRNA-splicing factor prp1
- U4/U6.U5 tri-snRNP-associated protein snu66
- Uncharacterized protein C1782.03
- Pre-mRNA-splicing factor brr2
- Pre-mRNA-splicing factor spp42
- LSM complex subunit lsm7
- 13 kDa ribonucleoprotein-associated protein
- U4/U6.U5 small nuclear ribonucleoprotein component snu23
Sequence:
MNENEGISLGELETRPFSEGITRFTKEQAAYYAEQKEKDRIKALKIPYEDSKVREYLRRYGEPITYFGEDALARRQRLQQLMIEKSLEGDNPLDVDQGASENIEKETYVQGSHELLVARKKIALYSLEKAKLRLKKEREISEIPVPEIVLSGKSSIEHLQKAELMGSQIGGERPIAIVRFSNNGNHFASGSWGGQVKVWNSDNLSEVQLFRGHTDRVSGLDWYPLCQAWDADSEQLTLATGAADNTVCLWKASQSTPLLRLEGHLARVGRVAFHPSGDYLVSASFDTTWRLWDVHTGVELLMQEGHSEGIFSIACQPDGSLVSSGGNDAIGRIWDLRSGKSIMVLDEHIRQIVAMAWSPNGYQLATSSADDTVKIWDLRKVSLAHTIPAHSSLVSDVRYIESGVNRFIATSGYDGCVKLWNPLNCSLIKSMVGHEEKVMSVDGYGDRFISSGYDRTIKLWYP
Protein: Calcium-binding protein CML38 (Calmodulin-like protein 38) (Q9SRE6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor that binds calcium in vitro.
Interaction partners:
- Probable calcium-binding protein CML43
- Calcium-binding protein CP1
- Probable calcium-binding protein CML44
- Probable calcium-binding protein CML47
- Protein RALF-like 1
- Uncharacterized protein At1g76660
- Probable WRKY transcription factor 40
- At1g73440
- Probable calcium-binding protein CML46
Sequence:
MKNNTQPQSSFKKLCRKLSPKREDSAGEIQQHNSSNGEDKNRELEAVFSYMDANRDGRISPEELQKSFMTLGEQLSDEEAVAAVRLSDTDGDGMLDFEEFSQLIKVDDEEEKKMELKGAFRLYIAEGEDCITPRSLKMMLKKLGESRTTDDCRVMISAFDLNADGVLSFDEFALMMR
Protein: Regenerating islet-derived protein 4 (REG-4) (Q9D8G5)
Organism: Mus musculus (Mouse)
Function: Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Serine protease inhibitor Kazal-type 4
Sequence:
MASKGVRLLLLLSWVAGPEVLSDILRPSCAPGWFYYRSHCYGYFRKLRNWSHAELECQSYGNGSHLASVLNQKEASVISKYITGYQRNLPVWIGLHDPQKKQLWQWTDGSTNLYRRWNPRTKSEARHCAEMNPKDKFLTWNKNGCANRQHFLCKYKT
Protein: Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (Q9US24)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity). Plays a role in meiosis and sporulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Autophagy protein 5
- Ubiquitin-like modifier-activating enzyme atg7
- Autophagy-related protein 3
- Serine/threonine-protein kinase atg1
- Autophagy-related protein 8
- Putative lipase atg15
- Autophagy-related protein 18
- Phosphatidylinositol 3-kinase pik3
- Serine/threonine-protein kinase vps15
- Autophagy-related protein 9
Sequence:
MTGLVDQQELEKRLATEEDSQNEDIENQLPSIETIINTYREKENRRVNLRFKAIGRTPLLRKTVFSINASQRFEKVTRFLKKELGLPMNSSLVLYVNSSFAPSPDEIVGNLYDNFAIDSHLLINYCINVAFG
Protein: RPM1-interacting protein 4 (Q8GYN5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential regulator of plant defense, which plays a central role in resistance in case of infection by a pathogen. It is a common target for both type III avirulence proteins from P.syringae (AvrB, AvrRpm1 and AvrRpt2) and for the plant Resistance (R) proteins RPM1 and RPS2. In strains carrying the appropriate R gene for avirulence proteins of the pathogen, its association with avirulence proteins triggers a defense system including the hypersensitive response, which limits the spread of disease. In contrast, in plants lacking appropriate R genes, its association with avirulence proteins of the pathogen impairs the defense system and leads to the pathogen multiplication.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:11955429, ECO:0000269|PubMed:12581526}; Peripheral membrane protein {ECO:0000269|PubMed:11955429, ECO:0000269|PubMed:12581526}.
Interaction partners:
- Disease resistance protein RPM1
- Disease resistance protein RPS2
- Serine/threonine-protein kinase RIPK
- Exocyst complex component EXO70B1
- ATPase 2, plasma membrane-type
- Serine/threonine-protein kinase PBS1
- Protein NDR1
- Mitogen-activated protein kinase 4
- Cysteine and histidine-rich domain-containing protein RAR1
- LRR receptor-like serine/threonine-protein kinase EFR
Sequence:
MARSNVPKFGNWEAEENVPYTAYFDKARKTRAPGSKIMNPNDPEYNSDSQSQAPPHPPSSRTKPEQVDTVRRSREHMRSREESELKQFGDAGGSSNEAANKRQGRASQNNSYDNKSPLHKNSYDGTGKSRPKPTNLRADESPEKVTVVPKFGDWDENNPSSADGYTHIFNKVREERSSGANVSGSSRTPTHQSSRNPNNTSSCCCFGFGGK
Protein: Lysine-specific histone demethylase (EC 1.14.99.66) (A0A8I6G2K8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR038051}.
Interaction partners:
Sequence:
MLSGKKAAAAAAAAAAAAAGTEAGPGAAGGAENGSEVAAPPAGLAGPADIATGAAGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTAGPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPIKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
Protein: Matrilysin (EC 3.4.24.23) (Matrin) (Matrix metalloproteinase-7) (MMP-7) (Pump-1 protease) (Uterine metalloproteinase) (P50280)
Organism: Rattus norvegicus (Rat)
Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
Interaction partners:
- 72 kDa type IV collagenase
- Metalloproteinase inhibitor 3
- Metalloproteinase inhibitor 1
- Stromelysin-1
- Osteopontin
- Metalloproteinase inhibitor 2
- Cathepsin K
- CD44 antigen
- Neutrophil collagenase
- Opticin
Sequence:
MAAMRLTLFRIVCLLPGCLALPLSQEAGEVTALQWEQAQNYLRKFYLHDSKTKKATSAVDKLREMQKFFGLPETGKLSPRVMEIMQKPRCGVPDVAEFSLMPNSPKWHSRTVTYRIVSYTTDLPRFLVDQIVKRALRMWSMQIPLNFKRVSWGTADIIIGFARGDHGDNFPFDGPGNTLGHAFAPGPGLGGDAHFDKDEYWTDGEDSGVNFLFVATHELGHSLGLGHSSVPSSVMYPTYQGDHSEDFSLTKDDIAGIQKLYGKRNKL
Protein: Phosphatidylserine decarboxylase proenzyme (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain] (P0A8K1)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Only decarboxylates the lipid-linked form of the serine moiety, and not serine alone or derivatives like phosphoserine or glycerophosphoserine.
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00662, ECO:0000269|PubMed:4598120}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00662, ECO:0000269|PubMed:4598120}.
Interaction partners:
- CDP-diacylglycerol--serine O-phosphatidyltransferase PssA
- Bifunctional protein Aas--phospholipid O-acyltransferase); Acyl-[acyl-carrier-protein] synthetase
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Phospholipase A1
- Phosphatidate cytidylyltransferase
- Miniconductance mechanosensitive channel MscM
- Phosphatidylglycerophosphatase A
- Cardiolipin synthase A
- Glycerol-3-phosphate acyltransferase
- Cardiolipin synthase C
Sequence:
MLNSFKLSLQYILPKLWLTRLAGWGASKRAGWLTKLVIDLFVKYYKVDMKEAQKPDTASYRTFNEFFVRPLRDEVRPIDTDPNVLVMPADGVISQLGKIEEDKILQAKGHNYSLEALLAGNYLMADLFRNGTFVTTYLSPRDYHRVHMPCNGILREMIYVPGDLFSVNHLTAQNVPNLFARNERVICLFDTEFGPMAQILVGATIVGSIETVWAGTITPPREGIIKRWTWPAGENDGSVALLKGQEMGRFKLGSTVINLFAPGKVNLVEQLESLSVTKIGQPLAVSTETFVTPDAEPAPLPAEEIEAEHDASPLVDDKKDQV
Protein: Cilia- and flagella-associated protein 95 (Q32L77)
Organism: Bos taurus (Bovine)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37327785}. Cell membrane {ECO:0000250|UniProtKB:Q5VTT2}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q5VTT2}.
Interaction partners:
- Sperm-associated antigen 8
- Outer dynein arm-docking complex subunit 2
- Tektin-1
- Tektin-4
- Cilia- and flagella-associated protein 276
- Protein Flattop
- EF-hand domain-containing protein 1
- Cilia- and flagella-associated protein 52
- RIB43A-like with coiled-coils protein 2
- EF-hand domain-containing family member B
Sequence:
MDSSDSSCQEWCSHGQYWLELGPTDLMERKGSLTLRSHHKKYSKPVLVYSWHRDRETYPKDYDIEGPEEVKKLCNSTYRRLGTSEPPVWISETREKMAQVCLNTKLAKIKSKALLNEETMNSGIIERDTGLPATGFGALFTRHSPDWSKMCTLTTYAEEYAPPYEYQPLGDPCQDDDYSIVHRKCRSQFTDLDGSKRVGINTWHDESGIYANSYVKRKLYSLTGGPIAPFLK
Protein: TAP2 protein (Q9UMW6)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
EVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQLQ
Protein: Probable pseudouridine-5'-phosphatase YKL033W-A (EC 3.1.3.96) (Q86ZR7)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Nucleotidase with XMP as the best in vitro substrate. Low catalytic efficiencies of YKL033W-A observed with XMP and other substrates suggest that these could be secondary activities for this protein, and its primary substrate is not yet identified. May possess pseudouridine 5'-phosphatase activity and together with dTTP/UTP pyrophosphatase YOR111W might constitute a pathway for the detoxification of pseudouridine 5'-triphosphate (Psi-UTP) and -monophosphate (Psi-UMP).
Interaction partners:
- Serine/threonine-protein kinase PTK1/STK1
- Suppressor of lethality of KEX2 GAS1 double null mutant protein 1
- Dilute domain-containing protein YPR089W
- Cell wall protein PIR5
- Uncharacterized protein YJL107C
- Uncharacterized protein YJL016W
Sequence:
MTHPVAVKACLFDMDGLLINTEDIYTETLNETLAEFGKGPLTWDVKIKLQGLPGPEAGKRVIEHYKLPITLDEYDERNVALQSLKWGTCEFLPGALNLLKYLKLKNIPIALCTSSNKTKFRGKTSHLEEGFDLFDTIVTGDDPRIAKGRGKPFPDIWQLGLKELNEKFHTDIKPDECIVFEDGIPGVKSAKAFGAHVIWVPHPEAHAVLGDTEALLAGKGELLSSLEKLEMSKYGL
Protein: TPX2 domain-containing protein (TPX2-related alternative variant b) (Q8WSN6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSKSQTIQEFDENFFSSFAVPKVKDYSRLSSSPSRDQPCETSYFENHFPSLECDTPVKMQLPKTKRESDDDLPSPTIDNLLSSSSESTVINASQNDNTEEKQQQPIREPLKIVPNEDASASGSGGENQLIEGLEKLSMFAPKAPEERLSQRRRSEQRKKEEEDKRTSVIAPASGTRSRSISTKRSMSREPAAAAPRAPSVPRPPHNSVTRTISAPIANTGPGVITRAMAARVAENVTKTSVRRSVMPLKVAQKTPVAAVKSDAATAGGDRSRDRTRRTNTTASRRSVFPNKPAAAAANTTPIAPPRRSASANKATAPTSVSKLTPKIRPIATANRSSILRMNVVKPTVPAPAPADAQQNKAASRPAVPAGGAARNRQPLRVNPGTPSTTIKKPPVASSVQRQPPTRARSVDRSGQPPISASTPGKASRADLFNRLATPKVTATPTRTSHEGPASSIRKSAVRPVPSYVYSSYKGYEKKRWIY
Protein: Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2) (O35239)
Organism: Mus musculus (Mouse)
Function: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAVELFHCYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPHKSAQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILSSLPPALDWDSVHVPGPHAMTIQELVDYVNTRQKRGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSMAVGNLGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEREGMVPSGHSLLAMDGQ
Protein: Hig-anchoring scaffold protein, isoform D (IP14803p) (Q058W1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNRLLLQCLVTTILVYKVISVPTSTMSTSIQTTSEIPQQDDDDDDWEEDDDSLESDDDGRVYKNPRNSPSTECPRDEEQATLLGQKCLRKCSSDEDCKSKKKKCLCDGVCGNSCIKPDRECPELAQPSLGQVTVAGRHFGARASYACPHGYHVVGLQSRLCQADGNWAGAEPACKQNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDIQCEPRSCGQPPDPAYGWHAGECYTYGCKITYNCGTGYELVGKHERYCQSDGSWTPKELPTCVSDSANVTTTQASLS