wanglab/gogpt-training-data huggingface dataset:
Protein: Protein DEK (Q7TNV0)
Organism: Mus musculus (Mouse)
Function: Involved in chromatin organization.
Subcellular location: Nucleus {ECO:0000269|PubMed:17524367}. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei. {ECO:0000250}.
Interaction partners:
- Regulator of nonsense transcripts 1
- Tyrosine-protein kinase BAZ1B
- Myb-binding protein 1A
- Splicing factor 3B subunit 1
- Nucleolar RNA helicase 2
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- DNA excision repair protein ERCC-6
- RNA-binding protein with serine-rich domain 1
- Nuclear pore complex protein Nup214
- Unconventional myosin-Ic
Sequence:
MSAAAAPAAEGEDAPVPPSSEKEPEMPGPREESEEEEEDDEDDDEEDEEEEKEKSLIVEGKREKKKVERLTMQVSSLQREPFTVTQGKGQKLCEIERIHFFLSKKKPDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSTQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRILNFLMHPKPSGKPLPKSKKSSSKGSKKERNSSGTTRKSKQTKCPEILSDESSSDEDEKKNKEESSEDEEKESEEEQPPKKTSKKEKAKQKATAKSKKSVKSANVKKADSSTTKKNQKSSKKESESEDSSDDEPLIKKLKKPPTDEELKETVKKLLADANLEEVTMKQICKEVYENYPAYDLTERKDFIKTTVKELIS
Protein: SAGA complex subunit spt20 (O14174)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- SAGA complex subunit Spt7
- SAGA complex subunit Spt8
- SAGA complex subunit Spt3
- SAGA complex subunit Hfi1
- SAGA complex subunit Sgf73
- SAGA complex subunit Sgf11
- Histone acetyltransferase gcn5
- SAGA complex/NuA4 acetyltransferase complex subunit Tra1
- SAGA complex subunit Ada2
- SAGA complex subunit Sgf29
Sequence:
MERNNGLGDYTYRYHGKELSLDDFQNKQGIESSDDAFLSKIYENVSNFNVPRKLHDIEHKFSKEEPSLILHIHKFHFRFEQQDGAFTYNGPVKSILQYIRMELIPPDCLEVFRNSDVKFYDGCLTVRIIDHRQSPSADQTVQPQPGSTNQQQQNNTNPINNQPEDTKPNTNSPPVYHTVLRPTPETLWQDLCLLSESFANSLSDEAVLTLESNILLASEAPLFLTPAKSKAEMIQFMNQLADSAPPCTRKKPQGSAQLADEEAERLEKENLLLLMDDQRKRDFQPTFQRLQFIENVRRKRAILQQRQMQMQQQQKAQQQQSPKAQQPPAHLVQSAPVQRKTTPKIQRLPPSSIQIPPPKPMQKFPANAASSESPPNATGNFLPSGPVPANEPMLKRESVDLIKIRQLAILFQQRASQLKARGATREQITEILNRQAIAAGTDLATVMTVARNLHFQQLQMRQQQQQQQMKAER
Protein: Probable WRKY transcription factor 40 (WRKY DNA-binding protein 40) (Q9SAH7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor (By similarity). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00223}.
Interaction partners:
- WRKY transcription factor 18
- Probable WRKY transcription factor 70
- Probable WRKY transcription factor 60
- Magnesium-chelatase subunit ChlH, chloroplastic
- Probable WRKY transcription factor 63
- Probable WRKY transcription factor 38
- Transcription factor MYC2
- Zinc finger protein ZAT10
- Protein TIFY 10A
- Probable WRKY transcription factor 33
Sequence:
MDQYSSSLVDTSLDLTIGVTRMRVEEDPPTSALVEELNRVSAENKKLSEMLTLMCDNYNVLRKQLMEYVNKSNITERDQISPPKKRKSPAREDAFSCAVIGGVSESSSTDQDEYLCKKQREETVVKEKVSRVYYKTEASDTTLVVKDGYQWRKYGQKVTRDNPSPRAYFKCACAPSCSVKKKVQRSVEDQSVLVATYEGEHNHPMPSQIDSNNGLNRHISHGGSASTPVAANRRSSLTVPVTTVDMIESKKVTSPTSRIDFPQVQKLLVEQMASSLTKDPNFTAALAAAVTGKLYQQNHTEK
Protein: NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) (A3F7Q2)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
- Catalase isozyme 2
- Catalase
- Uncharacterized protein LOC107895061
- Uncharacterized protein LOC107920725
- Catalase isozyme 1
Sequence:
MATKVYIVYYSMYGHVEKLAEEIKKGAASVEGVEAKLWQVPETLSDEILGKMSAPPKSDVPIITPHDLPEADGFIFGFPTRFGMMSAQFKAFMDATGGLWRTQQLAGKPAGIFYSTGSQGGGQETTPLTAITQLVHHGMIFVPIGYSFGAGMFEMEQVKGGSPYGAGTYAGDGTRMPSELEFAQAFHQGKYIAGITKKLKTAA
Protein: RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) (O54916)
Organism: Mus musculus (Mouse)
Function: May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.
Subcellular location: Membrane, clathrin-coated pit {ECO:0000250}. Note=Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits. {ECO:0000250}.
Interaction partners:
- RalA-binding protein 1
- AP2-associated protein kinase 1
- Epidermal growth factor receptor substrate 15
- ADP-dependent glucokinase
- AP-2 complex subunit alpha-1
- Ppfia1 protein,-interacting protein
- AP-2 complex subunit mu
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- Epsin-1
- Cyclin-G-associated kinase
Sequence:
MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRLAASYSSDSENQGSYSGVIPPPPGRGQVKKGPGSHDAVQPRPSAEQQEPVSPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLTGPGPFWSPFGDAQAGSSAGDAVWSGQSPPPPQDNWVSFADTPPTSALLTMHPASVQDQTTVRTVASAATANEIRRQSSSYEDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGEQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTSSDHTNPTSPLLVKPSDLSEENKINSSVKFPSGNTVDGYSSSDSFPSDPEQIGSSVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFAVTTGQQQAGVVAHPPAVPPRPQPSQAPGPSVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVSEEQDSEAEKHPEVLPAEKASDPSSSLRAAQADSKAEEKTATNVPANVSKGTTPLAPPPKPVRRRLKSEDELRPDVDEHTQKTGVLAAVLTSQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL
Protein: At4g10262 (Wound-responsive family protein) (Q8GY66)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytochrome P450, family 89, subfamily A, polypeptide 3
- Bifunctional nuclease 2
- Cytochrome P450 like protein
- Cytochrome P450, family 96, subfamily A, polypeptide 3
- Cytochrome P450, family 702, subfamily A, polypeptide 3
- At1g78490
- Zinc finger protein WIP4
- Cytochrome P450, family 706, subfamily A, polypeptide 3
- Peroxidase 65
- Protein OXIDATIVE STRESS 3
Sequence:
MSSASKTWMVAASIGAVEALKDQLGVCRWNYVIRSANQYLRNNLRSVSQAKKLSSSSIDYTNKTKQAEESLRTVMYLSCWGPS
Protein: Outer membrane porin F (Outer membrane protein 1A) (Outer membrane protein B) (Outer membrane protein F) (Outer membrane protein IA) (Porin OmpF) (P02931)
Organism: Escherichia coli (strain K12)
Function: Forms pores that allow passive diffusion of small molecules across the outer membrane.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:2464593}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}.
Interaction partners:
- Outer membrane porin C
- Vitamin B12 transporter BtuB
- Tol-Pal system protein TolB
- Intermembrane phospholipid transport system lipoprotein MlaA
- Maltoporin
- Outer membrane protein A
- Nucleoside-specific channel-forming protein Tsx
- Outer membrane protein assembly factor BamA
- Outer membrane porin PhoE
- Outer membrane protein TolC
Sequence:
MMKRNILAVIVPALLVAGTANAAEIYNKDGNKVDLYGKAVGLHYFSKGNGENSYGGNGDMTYARLGFKGETQINSDLTGYGQWEYNFQGNNSEGADAQTGNKTRLAFAGLKYADVGSFDYGRNYGVVYDALGYTDMLPEFGGDTAYSDDFFVGRVGGVATYRNSNFFGLVDGLNFAVQYLGKNERDTARRSNGDGVGGSISYEYEGFGIVGAYGAADRTNLQEAQPLGNGKKAEQWATGLKYDANNIYLAANYGETRNATPITNKFTNTSGFANKTQDVLLVAQYQFDFGLRPSIAYTKSKAKDVEGIGDVDLVNYFEVGATYYFNKNMSTYVDYIINQIDSDNKLGVGSDDTVAVGIVYQF
Protein: Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) (Q29116)
Organism: Sus scrofa (Pig)
Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Aggrecan core protein
- Neurocan core protein
Sequence:
MGVVTRLLVGTFLASLALPAQGGVLKKVIRHKRQTGVNVTLPEESQPVVFNHVYNIKLPVGSQCSVDLESASGDKDLAAPSEPSESVQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTSGAGCCLQPAEGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPSNCHLRGQCVDGQCVCNEGFTGEDCSQLACPSDCNDQGKCVNGVCVCFEGYSGVDCSRETCPVPCSEEHGRCVDGRCVCQEGFAGEDCNEPLCLHNCHGRGRCVENECVCDEGFTGEDCGELICPKDCFDRGRCINGTCYCDEGFEGEDCGRLACPHGCRGRGRCEEGQCVCDEGFAGADCSERRCPSDCHNRGRCLDGRCECDDGFEGEDCGELRCPGGCSGHGRCVNGQCVCDEGRTGEDCSQLRCPNDCHGRGRCVQGRCECEHGFQGYDCSEMSCPHDCHQHGRCVNGMCVCDDGYTGEDCRELRCPGDCSQRGRCVDGRCVCEHGFAGPDCADLACPSDCHGRGRCVNGQCVCHEGFTGKDCGQRRCPGDCHGQGRCVDGQCVCHEGFTGLDCGQRSCPNDCSNWGQCVSGRCICNEGYSGEDCSQVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIVYTPTHEDGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKKSIPVSARVATYLPTPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETTYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEAKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTHEENQYSIGNLKPDTEYEVSLISRRADMSSNPAKETFTTGLDAPRNLRRISQTDNSITLEWRNGKAAADTYRIKYAPISGGDHAEVEVPRSPQTTTKATLTGLRPGTEYGIGVSAVKGDKESDPATINAATDLDPPKDFRVSELKESSLTLLWRTPLAKFDRYRLNYGLPSGQPVEVQLPRNATSYILRGLEPGQEYTILLTAEKGRHKSKPARVKASTAGEPEIGNLSVSDITPESFSLSWTATEGAFETFTIEIIDSNRFLETMEYNISGAERTAHISGLRPGNDFIVYLSGLAPGIQTKPISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDSFVLKIRDTKKQSEPLEITLLASERTRDITGLREATEYEIELYGISSGKRSQPVSAIATTAMGSPKEITFSDITENSATVSWMVPTAQVESFRITYVPITGGAPSVVTVDGTKTQTRLLRLLPGVEYLVSVIAVKGFEESEPVSGTLTTALDGPSGLVTANITDSEALAMWQPAIAPVDHYVISYTGDRVPEITRTVSGNTVEYALTNLEPATEYTLRIFAEKGPQKSSTITTKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTLKEVVVGPETTSYSLSGLSPSTHYTARIQALNGPLRSKMSQTVFTTIGLLYPFPRDCSQAMLNGDTTSGLYTIYVNNDKAQKLEVFCDMTSDSGGWIVFLRRKNGREDFYRNWKAYAAGFGDLKEEFWLGLDALSKITAQGQYELRVDLRDHGETAYAVYDRFSVGDARTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYKNCHRVNLMGRYGDNSHSQGVNWFHWKGHEYSIQFAEMKLRPSNFRNLEGRRKRA
Protein: Arylalkylamine N-acetyltransferase-like 2 (AANAT2) (EC 2.3.1.87) (Arylalkylamine N-acyltransferase-like 2) (EC 2.3.2.-) (Q9VMG0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the formation of long-chain N-acylserotonins and N-acyldopamines, which are important cellular signaling lipids. Catalyzes in vitro the formation of various N-acetyl-2-arylethylamines such as N-acetyltryptamine and melatonin.
Interaction partners:
Sequence:
MSAITIRAMTIGDYEEVEAFLAVHFFKQEPLMLIPQEDPKQSEVSSAEAELHRSLIPQDLSLVAVDGERIVGVVLAGELVPEDLEREYQEAEQKEITCLLDKIHKFLAGIERQANIFKHYGVERALYLYMLGVDVSIRRQRVGTRLVEATIELGRQRGFPVVTSTCSNQNSKRLMTALNMECILTKDYADYKDEHGEIVLRASEPHTSASVVAIRL
Protein: 2,4-dienoyl-CoA reductase 2 (A0A8I5ZQX0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}. Midbody {ECO:0000256|ARBA:ARBA00004214}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004654}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004654}.
Interaction partners:
Sequence:
MELSQPTSLSDHDEPASGPQRGVKGLVGPDAPRGWSDEPEEHAQLQRWPEGPNAPICWPEEVEEPHAPRRWAEEPSASRCLSQEPYESCHLAKELEEPDAPRCSSQEPDAPCHLAKDLEETDSPRCWPLEPDAPCHLAKEWEEPDVPRCWPQEPDAPCHLAKYLEEPDAPLCWPQEPDAFCYLLKEVEEPDVPRCRPQEPDAPCHLAEELEDLDAPRCWTQEPNESCNLAKELDEPDTPRCLSQEPDAPCLLAKEWEESDAPSCWPQEPDVGPQEPDVGCHLAKEREESDAPCLLTEELKEPDALQCWPQESDAPCLLAEELEEPDAPHCCSQEVDTECLSAKESEEPDASHLWPGEPDAPCLLVKEPEEADAPHCWPEEPEEPDALNAPCFWANEPDEPDAPRCWSEEPQVLCLWPEEQNTTQCWQEEPDASCFWSEDREEPKVSCLQFKEPEKPKVACSWPEELEDCCPTRGLPLEPLLAEGELLQACPGPPPDPGLALSLPSEPGTAQEEGARLRTVFDALDRDGDGFVRIEDFIQFATVYGAEQVKDLTQYLDPSGLGVISFEDFYQGIVAIRNGDPDGQLYSVEPVQDEEPPACADEFDDFVTYEANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDVDSAGGSGVPSECLDTMEEPDHGALLLLPGRSRPHSQAVVMVIGSEEHFEDYGEGSEAELSPETLCNGELDCEDPAFLTPSPAKRLSSRKVARYLHQSGTLTMEALEDPPPEPVECPEEDIADKVIFLERRVSELEKDSAAAGEQHGRLRQENLQLVHRANALEEQLKEQEFRAQEKVLEETRKQKELLCKMEREKSIEIENLQARLQQLDEENSELRSCTPCLKANIERLEEEKQKMLDEIEELTQRLSEEQENKRKMGDKLSHERHQFQRDKEATQELIEDLRKQLEHLQLLRLEMEQRRGRSSSLGLQEYNSRARESELEQEVRRLKQDNRNLKEQNDELNGQIITLSIQGAKSLFSTSFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAILETNPSILEVK
Protein: DDIT3 upstream open reading frame protein (Alternative DDIT3 proteins) (AltDDIT3) (A0A2R8VHR8)
Organism: Mus musculus (Mouse)
Function: Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9H6Z9}. Cytoplasm {ECO:0000250|UniProtKB:Q9H6Z9}. Note=Colocalizes with WDR83 in the cytoplasm. {ECO:0000250|UniProtKB:Q62630}.
Interaction partners:
- Cyclic AMP-dependent transcription factor ATF-4
- CCAAT/enhancer-binding protein beta
- CCAAT/enhancer-binding protein alpha
- DNA damage-inducible transcript 3 protein
- Cyclic AMP-dependent transcription factor ATF-3
Sequence:
MLKMSGWQRQSQNNSRNLRRECSRRKCIFIHHHT
Protein: Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) (Q91YD9)
Organism: Mus musculus (Mouse)
Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O08816}. Nucleus {ECO:0000269|PubMed:12871950, ECO:0000269|PubMed:14676198}. Cytoplasm {ECO:0000269|PubMed:12871950, ECO:0000269|PubMed:14676198}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (PubMed:12871950, PubMed:14676198). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (PubMed:12871950). {ECO:0000269|PubMed:12871950, ECO:0000269|PubMed:14676198}.
Interaction partners:
- Actin-related protein 2
- WAS/WASL-interacting protein family member 1
- Cell division control protein 42 homolog
- Src substrate cortactin
- SH2/SH3 adapter protein Nck1
- Hematopoietic lineage cell-specific protein
- WAS/WASL-interacting protein family member 3
- Growth factor receptor-bound protein 2
- Cofilin-1
- Cofilin-2
Sequence:
MSSGQQPPRRVTNVGSLLLTPQENESLFSFLGKKCVTMSSAVVQLYAADRNCMWAKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDAPNGPNLPMATVDIKNPEITTNRFYGSQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHSSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPGVVVPPPPPNRMYPPPPPALPSSAPSGPPPPPPPSMAGSTAPPPPPPPPPPPGPPPPPGLPSDGDHQVPAPSGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVSDGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDDDDEEDFEDDDEWED
Protein: Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] (P63268)
Organism: Mus musculus (Mouse)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Myosin-11
- Myosin regulatory light polypeptide 9
- Actin, aortic smooth muscle
- Myosin-9
- Myosin-10
- Myosin light polypeptide 6
- Myosin light chain 6B
- Myosin-14
- Calponin-1
- Leiomodin-1
Sequence:
MCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKPEYDEAGPSIVHRKCF
Protein: Tetratricopeptide repeat protein 30 homolog (TPR repeat protein 30 homolog) (Abnormal dye filling protein 1) (Q8I7G4)
Organism: Caenorhabditis elegans
Function: Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Specifically required for the kinesin osm-3 to dock onto and move the IFT particles which contain these precursors. Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for polyglutamylation of axonemal tubulin in sensory cilia.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:16049494}.
Interaction partners:
- Intraflagellar transport protein 52 C-terminal domain-containing protein
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 56 homolog
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein che-13
- Intraflagellar transport protein osm-1
- Clusterin-associated protein 1 homolog
- TRAF3-interacting protein 1
- CHE-2 protein
Sequence:
MNAMLNIKEGEFTSTIYTLIHEHKFNDAIRILQYQHERNPKNLAALSLLAYCYYYTQDFMNAADCYSQLSYNFPQYSQYKLYHAQSLYNAFRPADALAVVSMIQDENLLNESVKLEAAIKYQEDDLVNCRILVEQLPENDAAVIINTACIDYKEGNYEEALKKFNEATEFSGYQSGLAYSIALCHYRRGDYDSALKLISEIINRGVKDHPEFNIGMVTEGIDVNFIQNTQKLHESALIEAFNLKFAIYYRTKDFKAAKESLTDMPPRNEHDADPITLHNLAISNANSDFGDSSAKLQFLLGINPFPQETFANLLFLYCKNDYFGLAADVLAENPSHTFYCLNEYQFNLLEALIYMPTNPEESLKKLEKLEKECLDRLRKTAIEIQIKKEQKTTDSDDSLEMRNLIESYDDSLEMYLPVLMTYAKYYWDKRDYQAVEKLFRNSVDYCKEHDTWKLNVAHTIFMQEKKYKDAAAFYEPIVHKKYDDGILEVPAMILANLVVCYIMTNQTDEAELILKAVENEEEAALMMKPNEKFFHNSIISLVIGSLYCSKGNFEFGISRVVKALEPPEKKLGVDTWYYAKRCIVAAIELMAKNLLVMRDSVVMEVIQFLTSCEVPGRNIYTVPDDLFEQAGESKVKCNVTYEARMIKAALLMVFND
Protein: Integrin-linked protein kinase homolog pat-4 (ILK homolog) (Paralyzed and arrested elongation at two-fold protein 4) (Q9TZC4)
Organism: Caenorhabditis elegans
Function: Probable pseudokinase that acts as an adapter protein. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc-112 to integrin-mediated attachment sites. Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles. May be involved in thermotolerance and lifespan.
Subcellular location: Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:12015115, ECO:0000269|PubMed:23283987}. Basal cell membrane {ECO:0000269|PubMed:12015115, ECO:0000269|PubMed:17662976}; Peripheral membrane protein {ECO:0000269|PubMed:12015115, ECO:0000269|PubMed:24314125}. Note=Colocalizes in dense bodies and M lines with integrin pat-3. Localization to muscle attachment sites is regulated by pat-2, unc-52 and unc-112 (PubMed:12015115). Co-localizes with pat-3 and pat-6 at body wall muscle attachment sites (PubMed:12781130, PubMed:17662976). {ECO:0000269|PubMed:12015115, ECO:0000269|PubMed:12781130, ECO:0000269|PubMed:17662976}.
Interaction partners:
- LIM domain-containing protein unc-97
- Protein unc-112
- Paralyzed arrest at two-fold protein 6
- Integrin beta pat-3
- Ras suppressor protein 1
- Paxillin homolog 1
- FERM domain-containing protein
- Vinculin
- Integrin alpha pat-2
- LIM domain-containing protein pin-2
Sequence:
MSLSTHYHAHKPNVPIIMEDVFGWVREGNAFQVRVWLDDHEHDLNVGDDHAFSLLHWAAKGGHVAIAEMLLSRGARVNSTNMGDDTSLHLAAAHGHRQIVVKLLSRKADVNATNEHGMTPLHYACFWGYEQIAEDLISCGAAVNVCNKKGMTPLDVCQPMCKNTILEIAQEHGQSPNDRVPFKDTTWKGTKSRTRDATLSRYTGVDVSSLNLITKIAESHSGELWRGKWQGNDIVARILNVQEVTARISRDFQTEFPALRIFAHPNICAVLAAANQPPNLVIISQYMPFGSLYNVLHEQSSVVIDHGQAVRFALDIARGMSYLHSLDPMLLRFYLSSKHVVVDEELTAKLSMADTKFSFQEVGKAYSPAWMSPEALSRAPEDLNIRAADMWSFAILLWELNTREVPFSDLPPMECGMKIALEGLRVHIPPGIARNMNRLMNICMNEDPGRRPNFDQIIPILERMIL
Protein: Dehydrogenase-like protein (Q57WY0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- PROP1-like PPR domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Rhodanese domain-containing protein
- Uncharacterized protein
- Small ribosomal subunit protein mS41
- Small ribosomal subunit protein uS5 C-terminal domain-containing protein
- Ribosomal protein S23 mitochondrial conserved domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MSAIKRSLNVGVVGMGNMGVPIARNLGFKARSAMYLQIHSRALSKAKRVCDDLSVDGATCAMRIHDRYSTMTKWCDVIVLALADVKASRHALLEDNESLIMNARKGQIIVDHTTVDAETSRECAHEAARRGAYFLDAPMSGSPRACFNGQLLLMVGGDAETFQKMLPIFHMYADNVFHMGESGSGTAAKMISQALVASHNAAAAEALSMAHALGIEDQSKLVQVLDASWGSSTMLRRNAPLLQDLIRNPDKTPPTSAVSVDRLLSDLAHLDASLPKRGGEDEPFPVFDAALRSLAAASDAGMGDRDLASVVHYIEAGEAELRNRTRVPLGGEHLTGRTAATEANSSVNETPSTVNGSSEVPNEFGVEDFY
Protein: Ribosome biogenesis protein rlp24 (Q10353)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of nog1 to pre-60S particles. Activates and recruits ATPase afg2 to cytoplasmic pre-60S ribosomal particles.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q07915}. Nucleus {ECO:0000250|UniProtKB:Q07915}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250|UniProtKB:Q07915}.
Interaction partners:
- Probable nucleolar GTP-binding protein 1
- Eukaryotic translation initiation factor 6
- Ribosome biogenesis protein nsa2
- Ribosome assembly factor mrt4
- Ribosome biogenesis protein erb1
- Nucleolar GTP-binding protein 2
- Ribosome biogenesis protein ytm1
- Protein mak16
- Zinc finger protein bud20
- Ribosome production factor 2 homolog
Sequence:
MRVHTCYFCSGPVYPGHGIMFVRNDSKVFRFCRSKCHKNFKMKRNPRKVAWTKAYRKAHGKEMVYDTALAVTAARRNVPVRYDRNVIATTLNAMKRVSQVHAKRERLFYKKRLAGKRAQELQEAQKLIAQNVPQFTEPEGEVETAEVQEPQIVSDEEYTMEEEVAEPVKIPVLAKKRKNKKSRNSSSAMQMD
Protein: DNA repair and recombination protein rti1 (Rad twenty-two isogene 1) (Rad22 homolog) (O42905)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion.
Interaction partners:
- DNA repair and recombination protein rad22
- DNA repair protein rhp51
- Replication factor A protein 1
- Replication factor A protein 2
- ATP-dependent DNA helicase srs2
- DNA repair protein rad16
- Meiotic recombination protein dmc1
- ATP-dependent DNA helicase II subunit 1
- Ornithine decarboxylase antizyme
- F-box DNA helicase protein 1
Sequence:
MGSLPDQSSCEEFTDSQQDKMTKLLAMQLGPEYISRRSGPGGGSVTYLEAWKAIELANEIFGFNGWSSSIQDIHVDYVEETKEKKFNVGISVIVRVTLKDGSFHEDVGYGSIENCRVKALAYEKCKKEGTTDALKRALRNFGSSMGNCLYDKRYIQKILKMAPAQAEFNYDNLLRANKRPYARFAQKVSTPIESHANKSVKLEHKNSIEKKISNVDKPISDLIENDIHESLPALQNPPIQSHSETDLYADEELDSILMHHERPPIPESPRVEEFEELLNQFEGDEKVSVDKIDAHDKMTEAQVVKIPPVQFMNARVAAAENPHIKHEGMAFQLHKKSNSILKSSNIDHNRSMPIRRPSLTSNNSANTFSTK
Protein: Maltose excess-like protein (F4KH13)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Alpha-glucan water dikinase 2
Sequence:
MEGKAIATSLGGDRVLIFPCSPRSSFVFTSRLSSLPLKRASIGGAVSCSGVNGLTRWNSIVSTRRLVPVRSINSESDSDSDFPHENQQGNPGLGKFKEYQEWDSWTAKFSGGANIPFLMLQLPQIILNTQNLLAGNNTALSAVPWLGMLTGLLGNLSLLSYFAKKREKEAAVVQTLGVVSTHIVLAQLTMAEAMPIQYFVATSAVVTIGLIVNCLYYFGKLNNTQMQGYKKFDAGKKILKKPRTDHCSKKIQLWKLDYTID