wanglab/gogpt-training-data huggingface dataset:
Protein: Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) (P05094)
Organism: Gallus gallus (Chicken)
Function: F-actin cross-linking protein is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Z1P2}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P12814}. Cell membrane {ECO:0000250|UniProtKB:Q9Z1P2}. Cell junction {ECO:0000250|UniProtKB:Q9Z1P2}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q7TPR4}.
Interaction partners:
- Actin, cytoplasmic 1
- Actin, cytoplasmic 2
- Membrane associated guanylate kinase, WW and PDZ domain containing 1.
- Vinculin
- Uncharacterized protein.
- Catenin alpha 1.
- Parvin beta.
- Catenin alpha-2
- Uncharacterized protein.
- LIM domain 7.
Sequence:
MDHHYDPQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDAQGEAEFARIMSIVDPNRMGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYNGRDAVPGALDYMSFSTALYGESDL
Protein: BG642163, isoform A (BG642163, isoform B) (Male accessory gland protein) (Q3HKQ0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- BPTI/Kunitz inhibitor domain-containing protein
- Seminal fluid protein
- IP13478p
- GH23626p
- RT07891p
- RE43153p
- SCP domain-containing protein
- Serpin 28Db
- Sulfhydryl oxidase
Sequence:
MWKWIINIILLSVVQASKKVDGQISPRTTSQKILQPYPCNSPHPLTQFSQKYPNSGYLCYPQNEINKYLWYPPWSQWVGYQGYQTGNGLYAQLSTGSQISSFHHPNFQIPFVQLLTLPAPPSLIPPASPIPSHQYPGLFAPPSFAQFPGLLGSTGSGPSGIPNLPGTNASPGWSSPGSSIPSYQLPGIQQQPGSSPVEYPHAPIKPPSSAPAGWSSPGSPIPPPSLPGLPGTPDQNPWGSADRPAHPPASPIQPGWSPPGSSFPPSPQSGPPGPPNWNQLESANRPVYPPEMPIPPVWNSRRSSNPSAQLPPLQEAPLGSLGPSQLPPGLPAPPSWSSLESSNPLVQRPELMAPPSLSPSGSSNSVLQPLPAKPNWRSSGSPNSPLYPPGLPAPPSESIPDISPNQKTRSAGSPP
Protein: Cadherin EGF LAG seven-pass G-type receptor 2 (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) (Q9QYP2)
Organism: Rattus norvegicus (Rat)
Function: Receptor that may have an important role in cell/cell signaling during nervous system formation.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Proline/serine-rich coiled-coil protein 1
- Sortilin
- Vang-like protein
- Vang-like protein 2
- Myosin-binding protein H-like
Sequence:
EDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYILRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYILVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELRLSRALDNNRPLEAIMSVLVSDGVHSVTAQCSLRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGHCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPFCQVTTRSFPARSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVSVDGCDTGVALRFGAMLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRHFVGCMKNLQVDSRHVDMADFIANNGTVPGCPTKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQRFLGSSLVAWHGLSLPISQPWHLSLMFRTRQADGVLLQAVTRGRSTITLQLRAGHVVLSVEGTGLQASSLRLEPGRANDGDWHHAQLSLGASGGPGHAILSFDYGQQKAEGNLGPRLHGLHLSNMTVGGVPGPASSVARGFRGCLQGVRVSETPEGVSSLDPSRGESINVEPGCSWPDPCDSNPCPTNSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSACTRKPSAPHGYICECLPNYLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPSSPTCLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSVTFSELKGFAERLQRNESGLDSGRSQRLALLLRNATQHTSGYFGSDVKVAYQLATRLLAHESAQRGFGLSATQDVHFTENLLRVGSALLDAANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNFAGTKLPRYEALRGERPPDLETTVILPESVFREMPPMVRSAGPGEAQETEELARRQRRHPELSQGEAVASVIIYHTLAGLLPHNYDPDKRSLRVPKRPVINTPVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALMITFLFLTLLRALRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALHLYRALTEVRDVNASPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSMSVFLYILSARASCAAQRQGFEKKGPVSGLRSSFTVLLLLSATWLLALLSVNSDTLLFHYLFAACNCVQGPFIFLSYVVLSKEVRKALKFACSRKPSPDPALTTKSTLTSSYNCPSPYADGRLYQPYGDSAGSLHSASRSGKSQPSYIPFLLREESTLNPGQVPPGLGDPSGLFMEGQAQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEAAFPGEQGWDSLLGPGAERLPLHSTPKDGGPGSGKVPWPGDFGTTTKENSGSGPLEERPRENGDALTREGSLGPLPGPSTQPHKGILKKKCLPTISEKSSLLRLPLEQGTGSSRGSTASEGSRNGPPPRPPPRQSLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH
Protein: Receptor-like cytoplasmic protein kinase 1 (F6JSQ7)
Organism: Capsicum annuum (Capsicum pepper)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}.
Interaction partners:
Sequence:
MGCFPCSGEGDTSVKKPQKKIFETSDLNHQYKRVHRSQPKQDMPVARQFKVVKSEEVKIASRSTSRKDGGYSSTPPSDGKTGGATAQRFKFDQLVAATEDFKEDYFLGEGGFGKVYKGHLGGTGEIVAIKQLDPNGCQGVREFVVEVRTLSKADHPNLVKLIGCCAEGDQRLLVYEYMALGSLEDHLFDTWPNQKPLDWNIRMKIAAGAARGLEYLHDKMTPPIIYRDLKCSNILLGEEYHPKLSDFGLAKVGPSGDKTHVSTRVMGTYGYCAPDYAMTGQLTFKSDIYSFGVVLLEIITGRRAIDYTKSAAEQNLVSWARPLFKDRKKFYKMADPALDGHYPIRSLYQALAIAAMCVQEQPTIRPPIVDIVTALNYLASLKYDPEIEPPIRKSYKNQSSHKSINDEDSW
Protein: XPC complex subunit, DNA damage recognition and repair factor (D4A3D8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- UV excision repair protein RAD23 homolog B
- Centrin 2
- RAD23 homolog A, nucleotide excision repair protein.
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIH subunit 1
- General transcription and DNA repair factor IIH helicase subunit XPD
- DNA excision repair protein ERCC-1
- ERCC excision repair 8, CSA ubiquitin ligase complex subunit
- DNA excision repair protein ERCC-5
- X-ray repair cross-complementing protein 6
Sequence:
MGAGFFGGRGPIRSWGCGQAWHASGRSRHAETFGSPAWLSGGTPLASMARKRTAGGKRRKRGQEAEDNKATRPEESDADDFEDEKQKPPRKCFLPKVSQGKRKRDCSDPGDPTNGAAKKKVAKATTKSKNLKAVKEEALSDDGDDFRDSLSNCRKAKKHPKREVVDQGTDEDDSEDDWEEVEELTEPVLDMGENSATSRSDLPVKAVEIEIETPEQAKARERSEKIKMEFETYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNSICQQPDLLAIGLSIIPIRFTKVPLQDRDVYYLSNLVKWFIGTFTVNADLSASEQDSLQTTLERRIAIYSARDNEELVHIFLLILRALQLLTRLVLSLQPIPLKSAVAKGKKSSKETSLEGPGDSSEPSSNIPESHNKPKTSKRIKQEETLSEGSGKANARGKRGTATAGSRQQRKPSCSEGEEAKQEIQSHPQAQKRRVAAKVSYKEESESDGAGSGSDFELSSGEGQHSSDEDCKPGPRKQKRASAPQRSKAGSKSASKTQSGSQWEPPSFSVASSSSSACKRGKKISCGGEETDDRKAAGVDQWLEVFCEPQAKWVCVDCVHGVVGQPVACYKYATKPMTYVVGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYRSPLTEREKKEDQEFQAKHLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPESAAVLGYCRGEAVYSRDCVHTLHSRDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDHNDLGLFGHWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQMNLPNLHRVARKLGIDCVQAITGFDFHGGYCHPVTDGYVVCEEFRDVLLAAWENEQALIEKKEKEKKEKRALGNWKLLVRGLLIRERLKLRYGAKSEAAAPHANAGGGLSSDEEEGTSSQAEAARVLAASWPQNRETKEEQKPDYTKMTRRRRAAEASHLFPFEKL
Protein: At1g23710 (F5O8.26 protein) (Q9ZUC4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g14730
- Uncharacterized protein
- At5g46780
- At1g44770
- Uncharacterized protein At4g21930
- Elongation factor
- Uncharacterized protein
- At3g26990
- At3g50040
- At1g05410/T25N20_5)
Sequence:
MEVAFPSSPPVKCIADERLTEISMDFTKLGFPEEDEEIKKLERSWSKLEESVEFNEDDEEEEEEFSFACVNGEGSPITADEAFEDGQIRPVFPLFNRDLLFEYENEDDKNDNVSVTDENRPRLRKLFVEDRNGNGDGEETEGSEKEPLGPYCSWTGGTVAEASPETCRKSNSTGFSKLWRFRDLVLRSNSDGRDAFVFLNNSNDKTRTRSSSSSSSTAAEENDKKVITEKKKGKEKTSTSSETKKKTTTTKSAHEKLYMRNRAMKEEVKHRSYLPYKQVGFFTNVNGLSRNIHPF
Protein: Ventricular zone-expressed PH domain-containing protein (Protein melted homolog) (A2BID5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Golgi integral membrane protein 4b
- Thioredoxin reductase-like selenoprotein T1b
Sequence:
MHQLFRLVLGQRDLSRAGDLFSLDDSEIEDCLSQALEEIKVISCSPDYLTNDNDQAVVEICITRITTAIRETGSIERHGAALVSLWESCLEHNLQPQGKDEDTPHAKIASDITSCILQNYNRPPVMALAVPVAVRFLQQGNQELSRNMSSYLSLAAIAKAELLAQHTEAITCSVLAGNTMLLRVLPSVYPRQPEPIHQHVRELTAMMPRLDQTGRQHLLRLLQMISDLHPLVLSSLVPLLIGFLGDSDLGDSALGVLVNVAQSSPVSLAPFLSTLRNVGQKNPWLLGHIAKIHRAVGLTSEIQARGALQYLVSLLASMEHSAHHTLLLEIRCLTDRYTSILGGGGKDIYRMSNSFSAIARLLGRKLEADGAVSRGEEKVQDLPRPHEAESGSEMFAENLHLQVKIQAFEEKIGDEEVESEVDGASPGPQRRHSLGQAARDERREMRFNRSKSLALHAVRTRSINSDSSPEGEGLDLNAELNVCEAETSSVSSTPHNHTELTETQPDTSPNTEGAKVEDGDPRERDRLWIHLRDNMEEIKSFCAEMIKQIPVPEHCVIEDSHRGCVAKLSFSCPLKGHYCLYGKSSFSLCSSQPHLWIQIMLLALQSKESEALCCRDECVLQLRKLWEKTQLTGAHSFELAMTQTTVPHKKDVDSLQMYLEEVRFFDLFSYSEDKGGWLCFMCSNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFRRGKSKDELDNNTIELSKVQSVKVVAKKRRDRGLPRAFEIFTDSKTYVLKAQDEKHAEEWLQCINVAVAQAKERENREATTYL
Protein: CBP80/20-dependent translation initiation factor (O43310)
Organism: Homo sapiens (Human)
Function: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19648179}.
Interaction partners:
- Nuclear cap-binding protein subunit 1
- Nuclear cap-binding protein subunit 2
- ATP-dependent RNA helicase DDX19A
- Histone RNA hairpin-binding protein
- MIF4G domain-containing protein
- Dynactin subunit 1
- Elongation factor 1-alpha 1
- ATP-dependent RNA helicase DDX19B
Sequence:
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDNSLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQGYHPMPHEVEIAHTKKLFRRRRNDRRRQQRPPGGNKPQQHGDHQPGSAKHNRDHQKSYQGGSAPHPSGRPTHHGYSQNRRWHHGNMKHPPGDKGEAGAHRNAKETMTIENPKLEDTAGDTGHSSLEAPRSPDTLAPVASERLPPQQSGGPEVETKRKDSILPERIGERPKITLLQSSKDRLRRRLKEKDEVAVETTTPQQNKMDKLIEILNSMRNNSSDVDTKLTTFMEEAQNSTNSEEMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMVEGTKFRSLLLNMLQKDFTVREELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLRELLQSQDVKEDAVLCCSMELQSTGRLLEEQLPEMMTELLASARDKMLCPSESMLTRSLLLEVIELHANSWNPLTPPITQYYNRTIQKLTA
Protein: UPF0346 protein SP_0947 (Q97R80)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MRKSFYTWLMTERNPKSNSPKAILADLAFEESAFPKHTDDFDEVSRFLEEHASFSFNLGDFDSIWQEYLEH
Protein: Transcription factor EC (Q1JQ62)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPHLTDCSFYKMRDGARVANVQSHLENSKYHLNQTQAQQVKQYLALGSKLASQAHPVAHPLPGQALGTVPVMRNGHMPPVSDSSTPGSPVTLLTLANNHDSEFPMDEVIDDLIGLENGFKDGSLDCMEPGIIMQNNVSLNSSMLEVYGADQEHDTRVLAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQHARDLESRQKKLEQANRRLQLRIQELEIQAHAHGLPSMTASMGTVELSSHLLKQQHHQTQATAASQSAQAPQSTQPPIYPQEGVSSPEYTQRTSLPSIVGEQSDGSNNFSDPLSHFTYFFCSTLKEEHQRLDEILMDDPLSPFGTDPLLSAGSPTAASKESSRRSSFSSEETDDL
Protein: Catenin delta 1 (A0A8I5ZVG2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
Interaction partners:
Sequence:
MFQNGRFVGDADLERQKFSDLKLNGPQDHNHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTMTTRTVQPVPMGPDGLPVDASAVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYGRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPPDQYYWAPLAQHERGSLASLDSLRKGMPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPILVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEALPSVANSTGPHAASCFGAKKGKGKKPTEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTSEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVVSILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIPMSNMGSNTKSLDNNYSTLNERGDHNRTLDRSGDLGDMEPLKGAPLMQKI
Protein: Enthoprotin (Q6DGF2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYNERYDPEPKSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKARRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASPDQNASTHTPQSSAKPSVPSSKSSGDLVDLFDGSGQTTGGATDLFGGFADFGSAAASGSFPSQATSGNGDFGDWSAFNQAPSGPVASGGELFGSAPQPAVELISGSQPALGPPPAASNSSDLFDLMGSSQATMTSSQSMNFSLMSTNTVGLGLPMSRSQVRCLFPLGIVTYTY
Protein: Brefeldin A resistance protein (Caffeine resistance protein 1) (Q09146)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:8621569}.
Interaction partners:
- Exportin-1
- GTP-binding nuclear protein spi1
- Nucleoporin nup44
- Probable nucleoporin C890.06
- Nucleoporin nup107
- Nucleoporin nup85
- Nucleoporin nsp1
- Ran GTPase-activating protein 1
- Meiotically up-regulated gene 87 protein
- Ubiquitin-like protein pmt3/smt3
Sequence:
MTSKMENNKDESISTKNALEEKSNETKDETSKRKHDPAEEESAVSTKVSKSEPLEDKGNAEVKEFKETTKSNGVKPEVEITESTKIQKESNTEPCISTGGKVEEKELKVNKDVDENEGHVAVETGKKESAAKPAASVSPFSQFASFSNASSPFSNVSTASSEPKEEKSAFGAFASSKSAFTMKSVKDSPFKKFAAGTAVETESGSGKEKENDKKSSENFDELLANTSAKAFENQKGSAGETKSEPKEADKGSGDSTKSTMHQLSDSEIITGEEEEESIFSVRARLYVVADEKKTWKERGQGILKVNVPKQRGSGSGRLLMRNDAVHRVIMNVPLFQGMSKKSLQIASASSGGSANYLKIFVIENGKSVLYAVRVKDNSLAEQLRNHVLEAIPKGGREDA
Protein: Succinate-CoA ligase ADP-forming subunit beta (A0A0U1RQF8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQVSNCRHDTYGINL
Protein: Inactive phospholipid phosphatase 7 (Nuclear envelope transmembrane protein 39) (Phosphatidic acid phosphatase type 2 domain-containing protein 3) (Q91WB2)
Organism: Mus musculus (Mouse)
Function: Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity. Knockdown in myoblasts strongly promotes differentiation, whereas overexpression represses myogenesis.
Subcellular location: Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm.
Interaction partners:
- Trimeric intracellular cation channel type A
Sequence:
MPASQSRARARDRNNVLNRAEFLSLNQPPKGTQEPRSSGRKASGPSTQPPPSSDGARERRQSQQLPEEDCMQLNPSFKGIAFNSLLAIDICMSKRLGVCAGRAASWASARSMVKLIGITGHGIPWIGGTILCLVRSSTLAGQEVLMNLLLALLLDIMTVAGVQKLIKRRGPYETSPGLLDYLTMDIYAFPAGHASRAAMVSKFFLSHLVLAVPLRVLLVLWAFCVGLSRVMIGRHHITDVISGFIIGYFQFRLVELVWMSSNTCQMLISAW
Protein: Probable phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS) (O16129)
Organism: Drosophila melanogaster (Fruit fly)
Function: Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.
Subcellular location: Mitochondrion matrix {ECO:0000305}.
Interaction partners:
- Phenylalanine--tRNA ligase beta subunit
- Phenylalanine--tRNA ligase alpha subunit
- Tyrosine--tRNA ligase
- Tyrosine--tRNA ligase, mitochondrial
- Bifunctional glutamate/proline--tRNA ligase
- valine--tRNA ligase
- Lysine--tRNA ligase
- Probable proline--tRNA ligase, mitochondrial
- Probable arginine--tRNA ligase, mitochondrial
- Valine--tRNA ligase
Sequence:
MLLTLRVQGARHWLKSTRCLASSAAPAKSPSSPPQLEVSGSTYATDGWTNVTPKILSYVGANKHLQTDHPLSIIRQRIVNYFYGAYRNQRGNPLFSVYDQMNPVVTVQQNFDNLLIPADHVSRQKSDCYYINQQHLLRAHTTAHQVELISGGLDNFLVVGEVYRRDEIDSTHYPVFHQADAVRLVTKDKLFERNPGLELFEETWSGTLADPKLILPSSKFMDQTKQPCHTLEAVKLMEHEMKHVLVGLTKDLFGPRIKYRWVDTYFPFTQPSWELEIYFKDNWLEVLGCGIMRHEILQRSGVHQSIGYAFGVGLERLAMVLFDIPDIRLFWSNDSGFLSQFSEKDLHNLPKYKPISHYPQCTNDLSFWLPQDIEVDAGFSPNDFYDLVRSVAGDMVEQISLVDKFKHPKTGKSSVCFRIVYRHMERTLTQAEVNEIHKQIASASVDSFNVQIR
Protein: Heat shock 70 kDa protein, mitochondrial (75 kDa glucose-regulated protein homolog) (GRP-75) (Q8I0H7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May function in protein folding and assembly, and disassembly of protein complexes.
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- 60 kDa heat shock protein, mitochondrial
- GrpE protein homolog, mitochondrial
- Heat shock cognate 90 kDa protein
- Uncharacterized protein
- Mitochondrial import inner membrane translocase subunit tim17
- Cytochrome c oxidase subunit 5
- Endoplasmin homolog
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit Tim23
- Iron-sulfur cluster assembly protein
Sequence:
MLRSLKALKLNSLNAQKGIRQFCSDSKISGQVIGIDLGTTNSCVAVMQGAEARVLENAEGGRTTPSVVAFTEDNQKIVGLPAKRQMVTNAENTLFATKRLIGRRFDDPMTKKDMTMVPYKIVKGPNGDAWFEVKGKMISPSEAGAMVLQKMKETAETNLGGPVTDAVITVPAYFDDSQRQATRDAGTIAGLKVQRIINEPTAAALAYGFKKDEPKTVAVYDLGGGTFDISILEIVGGVFEVRATNGDTFLGGEDFDNALLEHFVAEFKKEKGIDLTKDTMATQRLREAAEKAKCELSSTLTTEINLPYISAGPSGPVHFNMKLTRSKFEQLVADLIQRTIGPCNICLKDAGLSTSEINEVILVGGMTRMPKVQELAKSTFNKEPFKGVNPDEAVAVGAAIQGGVLKGDTKGIVLVDVTPLSLGIETLGGVFTRLIKKNTNIPASKTDTFSTAADGQSEVEIKVFQGEREMAVDNKLLAKFTLFGLPPLPKGVPQIEVTFDIDVNGMLQVIAKDKATGKAQQVRIQTSGGLSKDDIARILKESEANAEVDRKRKELVEARNNGESVVYQVEKDLVEFKDYLSQPQTEEIKKAVQAVRDVLAKEDGSAIEAEIKKLHDLTRSSFETAYKAKLDSSASKSSSTENKENKDNTTEAEFTEKK
Protein: HTH-type transcriptional regulator CysB (Cys regulon transcriptional activator) (P0A9F3)
Organism: Escherichia coli (strain K12)
Function: This protein is a positive regulator of gene expression for the cysteine regulon, a system of 10 or more loci involved in the biosynthesis of L-cysteine from inorganic sulfate. The inducer for CysB is N-acetylserine. CysB inhibits its own transcription.
Subcellular location: Cytoplasm.
Interaction partners:
- Sulfate/thiosulfate import ATP-binding protein CysA
- Serine acetyltransferase
- Cysteine synthase A
- Glycine cleavage system transcriptional activator
- DNA topoisomerase 1
- Met repressor
- L-cystine transporter TcyP
- HTH-type transcriptional activator AaeR
Sequence:
MKLQQLRYIVEVVNHNLNVSSTAEGLYTSQPGISKQVRMLEDELGIQIFSRSGKHLTQVTPAGQEIIRIAREVLSKVDAIKSVAGEHTWPDKGSLYIATTHTQARYALPNVIKGFIERYPRVSLHMHQGSPTQIADAVSKGNADFAIATEALHLYEDLVMLPCYHWNRAIVVTPDHPLAGKKAITIEELAQYPLVTYTFGFTGRSELDTAFNRAGLTPRIVFTATDADVIKTYVRLGLGVGVIASMAVDPVADPDLVRVDAHDIFSHSTTKIGFRRSTFLRSYMYDFIQRFAPHLTRDVVDAAVALRSNEEIEVMFKDIKLPEK
Protein: Cytochrome b5 (P40312)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. It plays a role in fatty-acid desaturation and is also involved in several steps of the sterol biosynthesis pathway, particularly in the 4-demethylation of the 4,4'-dimethyl zymosterol.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Putative lipase ATG15
- Lanosterol 14-alpha demethylase CYP51
- C-22 sterol desaturase ERG5
- NADPH--cytochrome P450 reductase
- Cytochrome c isoform 1
- NADH-cytochrome b5 reductase 1
- NADH-cytochrome b5 reductase 2
- Cytochrome c isoform 2
- Acyl-CoA desaturase 1
- Plasma membrane-associated coenzyme Q6 reductase PGA3
Sequence:
MPKVYSYQEVAEHNGPENFWIIIDDKVYDVSQFKDEHPGGDEIIMDLGGQDATESFVDIGHSDEALRLLKGLYIGDVDKTSERVSVEKVSTSENQSKGSGTLVVILAILMLGVAYYLLNE
Protein: Solute carrier organic anion transporter family member 1A4 (Sodium-independent organic anion-transporting polypeptide 2) (Solute carrier family 21 member 5) (Q9EP96)
Organism: Mus musculus (Mouse)
Function: Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, prostaglandin E2, estrone 3-sulfate, L-thyroxine (T4), the cardiac glycosides ouabain and digoxin and thyroid hormones. Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Hepatic sodium/bile acid cotransporter
- Bile salt export pump
- Solute carrier family 22 member 7
- ATP-binding cassette sub-family C member 3
- ATP-binding cassette sub-family C member 2
- Cytochrome P450 3A11
- Nuclear receptor subfamily 1 group I member 2
- Organic anion transporter 3
- Prolactin-2C3
Sequence:
MGKSEKEVATHGVRCFSKIKAFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSVVGLINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFLISIPHFLMGRYEYETTILPTSNLSSNSFVCTENRTQTLKPTQDPTECVKEMKSLMWIYVLVGNIIRGMGETPIMPLGISYIEDFAKSENSPLYIGILETGMTIGPLIGLLLGSSCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQDNGDGTENAKEEKHREKIKEENRGITKDFFLFMKSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAYIGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTSYEGVQHPLYVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACLAGCEKSVGTGTNMVFQNCSCIQSSGNASAVLGLCDKGPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLRCMKSEEKSLGVGLHTFCMRILGGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRIYLGLPAALRGASFLPALFILILMRKFQFPGDIDSSDTDPAEMKLTAKESKCTNVHRSPTMQNDGERKTKL
Protein: Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) (P31647)
Organism: Rattus norvegicus (Rat)
Function: Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:8731228}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sodium- and chloride-dependent GABA transporter 2
- Cytosolic arginine sensor for mTORC1 subunit 2
- Excitatory amino acid transporter 2
- Vesicular inhibitory amino acid transporter
- Glutamate decarboxylase 1
Sequence:
MTAEQALPLGNGKAAEEARGSEALGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRMVTVNDCEAKVKGDGTISAITEKETHF