wanglab/gogpt-training-data huggingface dataset:
Protein: DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (mHR54) (mRAD54) (P70270)
Organism: Mus musculus (Mouse)
Function: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). Deficiency also resulted in an increased frequency of end-to-end chromosome fusions involving telomeres compared to the controls, suggesting a putative role in telomere capping. Non-homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA repair protein RAD51 homolog 1
- DNA repair and recombination protein RAD54B
- DNA repair protein RAD52 homolog
- Structure-specific endonuclease subunit MUS81
- Exonuclease 1
- Breast cancer type 2 susceptibility protein homolog
- Cellular tumor antigen p53
- Protein VAC14 homolog
- Fanconi anemia group M protein homolog
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
Sequence:
MRRSLAPSQLARRKPEDRSSDDEDWQPGTVTPKKRKSSSETQVQECFLSPFRKPLTQLLNRPPCLDSSQHEAFIRSILSKPFKVPIPNYQGPLGSRALGLKRAGVRRALHDPLEEGALVLYEPPPLSAHDQLKLDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPECKPEIEKAVVVSPSSLVKNWYNEVEKWLGGRIQPLAIDGGSKDEIDRKLEGFMNQRGARVPSPILIISYETFRLHVGVLKKGNVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKSRDAAASEADRQRGEERLRELIGIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPEEELREGKMSVSSLSSITSLKKLCNHPALIYDKCVAEEDGFEGTLGIFPPGYNSKAVEPQLSGKMLVLDYILAVTRSRSSDKVVLVSNYTQTLDLFEKLCRVRRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKICYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFTLDEASLSDTHDRLHCRRCVNNRQVWPPPDGSDCTSDLAQWNHSTDKRGLQDEVLQAAWDASSTAITFVFHQRSHEEQRGLH
Protein: ALG-1 (Q95R18)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MHGYQGNDPNYRRQPPYRQLHVDTRSPSSYSQQYVPYEADPGMNGDGWQGPGRGGPHHMNGGGGGRRGGGGGMHNQRIQQNPHHGGMNRMMPHGFRPQQGQFMPQYPPPPPMGGMPDVMDINMRMDGMSLGSTPSGIPGQYGDMGPPPVQQWNQPAPFVPPPQQDDLYDPSGYGGGAGGGGGHHPSHMPPYGQRGNNQNQYGNRMQGGQGGYRGNQQRQQQQQPQQGFNMPPMMVPPGQPPFYGGNQPNHHHQQPSFAPSPFSMGGGGGGSQGGPHEQHGPGGNQNGGFGVSSSSMDDYSMWTDENDEDAKKKKSLRDKGLSGWGDADVSNSKPIRRWIVPEGQEEDFETAMERCPSHLKKKALNEEALRRRLTSENPQIVAQAQQQAEEEANAMMRIGRRPIVPSGWGDIPSEISTDKSEFDQSSSRGWDEGSISGGGSGRHPSHHQSNDNSMWNSPSVGGGQSNSETRNPFFAQHMQQQQHQQQHQPHYGGYGDNGVLDGGSLWSAAVMDGSSMVPPHPTMGVGSSASSSSIPIGMLMMSGSGNVGGGPPSSSSLLDEDGSQKKLAENLKLAVQKGHLDISLLSLPHIPPNVLDLLTEILAVIPRLDDYEDELKKLGENRPSNYDEGASKEEKESWMSKDQKNDHDKAVIGVVTAKIEVTQLSKKITEALIEAGLLPPQPQTSTSANTSTNHLNHRGGPPPGSDGGAGPSTSRSGGGGAAGGDSFNSSGGGGPPDHYYDYSFLG
Protein: Histone deacetylase 19 (AtHD1) (HD) (EC 3.5.1.98) (O22446)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response. Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous floral organ identity genes. Involved in negative regulation of salinity stress response. Represses the expression of stress tolerance-related genes, genes coding for late embryogenesis abundant (LEA) proteins that prevent protein aggregation, and positive regulators of abscisic acid (ABA) signaling, such as ABI5 and NAC019.
Subcellular location: Nucleus {ECO:0000269|PubMed:15749761, ECO:0000269|PubMed:16699543}. Note=excluded from the nucleolus, but associated with the condensing chromatids.
Interaction partners:
- Paired amphipathic helix protein Sin3-like 1
- Protein TOPLESS
- Paired amphipathic helix protein Sin3-like 3
- Histone-binding protein MSI1
- Paired amphipathic helix protein Sin3-like 2
- Zinc finger CCCH domain protein
- Histone deacetylase complex subunit SAP18
- Histone deacetylase 6
- WD40 repeat-containing protein HOS15
- B3 domain-containing transcription repressor VAL2
Sequence:
MDTGGNSLASGPDGVKRKVCYFYDPEVGNYYYGQGHPMKPHRIRMTHALLAHYGLLQHMQVLKPFPARDRDLCRFHADDYVSFLRSITPETQQDQIRQLKRFNVGEDCPVFDGLYSFCQTYAGGSVGGSVKLNHGLCDIAINWAGGLHHAKKCEASGFCYVNDIVLAILELLKQHERVLYVDIDIHHGDGVEEAFYATDRVMTVSFHKFGDYFPGTGHIQDIGYGSGKYYSLNVPLDDGIDDESYHLLFKPIMGKVMEIFRPGAVVLQCGADSLSGDRLGCFNLSIKGHAECVKFMRSFNVPLLLLGGGGYTIRNVARCWCYETGVALGVEVEDKMPEHEYYEYFGPDYTLHVAPSNMENKNSRQMLEEIRNDLLHNLSKLQHAPSVPFQERPPDTETPEVDEDQEDGDKRWDPDSDMDVDDDRKPIPSRVKREAVEPDTKDKDGLKGIMERGKGCEVEVDESGSTKVTGVNPVGVEEASVKMEEEGTNKGGAEQAFPPKT
Protein: M-zodatoxin-Lt8h (M-ZDTX-Lt8h) (Cytoinsectotoxin-1h) (CIT-1h) (P85247)
Organism: Lachesana tarabaevi (Spider)
Function: Insecticidal, cytolytic and antimicrobial peptide. Has insecticidal activity against the flesh fly S.carnaria. Has antibacterial activity against the Gram-negative bacteria E.coli. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis.
Subcellular location: Secreted {ECO:0000269|PubMed:18215128}.
Interaction partners:
Sequence:
MKYFVVALALVAAFACIAESKPAESEHELAEVEEENELADLEDAVWLEDLADLSDLEETRGFFGNAWKKIKGKAEKFFRKKAAKIIAKKEGITKEEAEAKVDTMSKKQIKVYLLKHYGKKALQKASEKL
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q95S28)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MARITWRGHSTQELLSILRLRWSYMKHCWHSLTFNAHMNSSYASDVCLTPIFWFVDNYTHCLGPFFVVGVAALTTSVVSIAYWIGLPFWWAKSQLVTYFLLIVGNWLLLNVVFHYVMAVITPAGHPPEGVSLVEAVSMCGKCIAPKPPRTHHCSICNRCILKMDHHCPWLNNCVGYGNHRYFFLYMTYTTLGCLFLILFGLEIGHKYLWLDHGENWTEIEPWRGSQSSLTSVDTSFQ
Protein: Signal peptide peptidase-like 2 (AtSPPL2) (EC 3.4.23.-) (Q8W469)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:18067581}; Multi-pass membrane protein {ECO:0000269|PubMed:18067581}.
Interaction partners:
- Cell division related protein-like
- ARM REPEAT PROTEIN INTERACTING WITH ABF2
Sequence:
MDSLRFLRILLLSSSILLLSLRSTVTAGDIVHQDNLAPKKPGCENDFVLVKVQTWIDGVENEEFVGVGARFGKRIVSKEKNANQTHLVFANPRDSCTPLKNKLSGDVVIVERGNCRFTAKANNAEAAGASALLIINNQKELYKMVCEPDETDLDIQIPAVMLPQDAGASLQKMLANSSKVSAQLYSPRRPAVDVAEVFLWLMAIGTILCASYWSAWSAREAAIEHDKLLKDAIDEIPNTNDGGSGVVEINSISAIFFVVLASGFLVILYKLMSYWFVELLVVVFCIGGVEGLQTCLVALLSRWFQRAADTYVKVPFLGPISYLTLAVSPFCIVFAVLWAVYRVHSFAWIGQDVLGIALIITVLQIVHVPNLKVGTVLLSCAFLYDIFWVFVSKKLFHESVMIVVARGDKSGEDGIPMLLKIPRMFDPWGGYSIIGFGDILLPGLLIAFALRYDWLANKTLRTGYFIWAMVAYGLGLLITYVALNLMDGHGQPALLYIVPFTLGTMLTLARKRDDLWILWTKGEPERACPHHVRLEQCSEK
Protein: peptide-methionine (S)-S-oxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (C8V8B9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Thioredoxin
- Thioredoxin, putative
- Glutaredoxin Grx1, putative
- Glutaredoxin domain protein
- Queuine tRNA-ribosyltransferase accessory subunit 2
Sequence:
MAFAAPTLGSTVFSRLFRTFSTTSPSLSHTTESISRNMTSSSTQTATLAAGCFWGVEHLFRKQFGQGKGLLDAKVGYCGGNTASPNYRAVCTGDTGHAEALKITFDPSLVSYRSLLEFFYRMHDPTTKNQQGPDVGTQYRSAIFTHGDEQHKIAESVTEKVSKEWYKQPLSTEIIPAGQWWDAEEYHQLYLHKNPSGYECPAHFVRSFPPLSE
Protein: Chaperone protein HscA (Hsc66) (P0A6Z1)
Organism: Escherichia coli (strain K12)
Function: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.
Interaction partners:
- 2Fe-2S ferredoxin
- Iron-sulfur cluster assembly scaffold protein IscU
- Co-chaperone protein HscB
- Protein IscX
- Iron-binding protein IscA
- Chaperone protein DnaJ
- Cysteine desulfurase IscS
- HTH-type transcriptional regulator IscR
- Chaperone protein HtpG
- Iron-sulfur cluster assembly protein CyaY
Sequence:
MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLADHEGRHLLPSVVHYQQQGHSVGYDARTNAALDTANTISSVKRLMGRSLADIQQRYPHLPYQFQASENGLPMIETAAGLLNPVRVSADILKALAARATEALAGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADYIREQAGIPDRSDNRVQRELLDAAIAAKIALSDADSVTVNVAGWQGEISREQFNELIAPLVKRTLLACRRALKDAGVEADEVLEVVMVGGSTRVPLVRERVGEFFGRPPLTSIDPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPALPAGGAHIRVTFQVDADGLLSVTAMEKSTGVEASIQVKPSYGLTDSEIASMIKDSMSYAEQDVKARMLAEQKVEAARVLESLHGALAADAALLSAAERQVIDDAAAHLSEVAQGDDVDAIEQAIKNVDKQTQDFAARRMDQSVRRALKGHSVDEV
Protein: Tubulin alpha chain (A9PL19)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Uncharacterized protein LOC107899987
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
- Tubulin beta chain
Sequence:
MRECISVHIGQAGIQVGNACWELYCLEHGIQPDGQMPSDKTVGGGDDAFNTFFSETGAGKHVPRAIFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLVSQVISSLTASLRFDGALNVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTSVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESGEGDEGDEEEY
Protein: Odorant receptor M37 (Olfactory receptor 961) (Olfactory receptor MOR224-5) (Olfactory receptor Olfr961) (Olfactory receptor family 10 subfamily D member 4C) (Q9EQ84)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- RIKEN cDNA 1700001J03 gene
- Uncharacterized protein C2orf74 homolog
Sequence:
MTNHTMVTEFTLLGIPETEGLENALLFLFSTMYACALLGNFLILTAITTSPRLHTPMYFFLGNLSIFDLGFCSTTAPKMLSYLSGWGGGISFQGCVVQHFFYHCLGCTLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTSLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLIIVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSPLLSAIIQILHNLVTPTINPLIYSLRNKDVKAALRHVFLKRCLSLEVNENS
Protein: Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC 2.1.1.43) (Q8I5K3)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MSISPLKYESKILSNLANMLKLSEKSDDEILSEINQGNENKVFEIDDDVKQVVDLNKINCTCEESKKKIEECDKKKFVYNYNIETYGVDFFLDICNALSRSNYKPYLSEEGKKEIMNGLRVRRNSNLYKYVSFFLSKERMNKERMDDGKKVENIYHCFKCLKSVLHICIDDEDSNNNNNNNNKMKTALYLKNNNSITEQIENKIENDILNEQNSSLEKVNHRKGVISVSKYKSELTSITRMSNEIIMQTILEHTKDMGIKKDTTKNIQSRNDNKNDHGDEDDHRTNNINSNMKNSNNNNNNNNNNIIKKSKTYESVKVRNNYYYNDDHDYDNHIYQTENVIDNNNTEPTKRNIPKRTVVQKKSYVQRKTNITNKKRISQNKPVTRNSYKKNDRINTTCDVRASKIKDTIYEKKKKKVRRSFEVNANRRKRGAGQKGVFSDEEGMKMDNDNKIDDNTLNNNKIDGNILDNNKIDGNILDNNKIDGNILDNNKIDGNISDNNKIDDKTLNNNKIDDKTSDNNKIDDIISDHNKIDGNTPNNNKIDDNTSNNNKIDGNTPNNNKIDDNTLKDNITNNILDDNAVPKEVDNNCENDKNVHNKESCRNDIYSSIQISNTYNNTMINSTFVEEKNIISNIMDNTNIYPYNLCNVNNMEDPNLSNNPEKEYIKENHLCDLPNDIITSNGEDIKNKEIYKMDHPNKALLSNNTNEKDYDYNESDNASYSTDDSKYVKYLKKKKKLQEQGKIIIDLNLFNGNSVKTTNKRDKEEKLQEKLRMKQIKKLLDEKQMVICKIEDIAKKRNKKYVKAQVLSKDSKIERAYFSHKMKKFYNSKSSYFGCGWSSNKKEWTPFIHAPFFENQHNAIYKNRNKKLYEEIYDTLLHGRIHPDIKVVELKDHKHPIRLCTPYNEDCYSVVYTGKKINATDDRVIFGEYTGYVANNKELSQEKHQYMFALTFNKKVFNDRKHVVFINEVELDEEQNYSSHVVSNVMNKVKAHEKNNINNTNIYNSPHILNGNNNNNINSNTTEETMSNRKIDKIKPVSNVIIPDYNNLNSYINKCKTNEHNKKSRDINNLIILPDNYTYAVDSSYMFNEMSLVNHYKTCSVFNNFDFRINSEWQLVYLDGWPHIILTSIPGVEINPGEEIFADFGFEWFEKVNDICLNEFIKNNYFYRLYKLNTSREILFNGMEDIVEKYNLLKNHITCNICMHNVNTDGNNFILCSGCNHVYHLKCVHKFNTEVNENYEWFCSSCLQFCFNIIKQKEFVDYIEKENQKRFIQLLDDLNGDNLDTVNNEKKSDALDKLNNYNCVGNINNSNSIDNIDNRDGLDNPNNSNISYGVKNSNISYDANNSNISYDANNSNISYGVNNSNISYGADNSNISHSFNNSNISHSFNNSNISHSANNSNISHSANNSNSEDKTNNCNIEDKTNNCNIEDKTNNCNSEDKTNNCNNEDKTNNCNIEDKTNNCNNLDKEDDINDMNKINKSNQIIIKDVNDNNLFPVENNDKQKYLEVLENIRKLLQCKENIDDLFKNKEYVNSFLQKIDDEMNMFENKRSEDESVKLDDLKHIFENSFELHLLIDYKKKLEDLLESTEKVDSFLNDKNVLNTMKIRKRTLSFLMENKKYIDNFIQMNEEKDYAKINECEKKKEEDIIHNTTCRKVEKLEDRIIQNSHNNQLANPEYCSTLKGEEDKSVSLIDNKSMCERVDNHSICNEVNSSISSTYEKTLYNKSNNIIRNLKEMKKYERECQNNNSYSNMYCSYMMKLSKKILGFPLIKDFSKGLSTLEPSLPLNDHLKKLSVCSNCYSKHHDLAKAIICRVTKMHFEANYNDYLTDEDLFKTSSEFIQSVIRELANTVKEYRKKELNRVYLQHATENDSMILDRVNKDMSLELNYNNVTPTRTSIHNCSCTKTNKEYNESFYKIVSPSFNNDTVEKSNIIIQENNHIRNNEILQLGEEEVGNYECQNKEVIGSDTKEHTNERINDQTSEEKCHDDFYSKDMHILYKNTFLPREEIDNCSIEKINDVEEKKMTHQHEENDILKDVINDTLNDMSNDVPNDMSNDVPNGMSNDVPNGMSNDVPNDISNDVPNDISNDVSNDVPNDVSNDISNDVSNNVPNDVSNDVPNDVPNDVPNDVPNDVPNDTSITNLYEQKNDLNSYEKSCKLNNFIPLIGVELGKTKFQREFTNGTFVGRVTEQIKDENNNNFFVVTYEDGDVEWITPSFLFQEILKQSTNNTTYPLASTFKDIFYEDFKKDIKLNNHSYELKIEKKKRKSMFEYVPNNNVTKRQRHAFEENVLKKKNTHQEVNTSQRSLSKLKNVVFNDSLKKTRKRTMSTS
Protein: Uncharacterized membrane protein YAL064W-B (O13512)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Topoisomerase I damage affected protein 8
- Putative uncharacterized protein YAR062W
- Uncharacterized protein YHR213W-A
Sequence:
MAGEAVSEHTPDSQEVTVTSVVCCLDSVVEIGHHVVYSVVTPLIVAVLIDTMAGEAVLEHTSDSQEEIVTTVVCSVVPLVCFVVSVVCFVISVVEIGHHVVYSVVAPLTVTVAVETIAEEMDSVHT
Protein: Rab3 interacting molecule, isoform Z (A0A0B4K6B7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRRKQDEVVTLEMQIRQRSEQQKKAGVELDATCHICLKTKFADGVGHICHYCNIRCCARCGGKVTLRSNKVIWVCILCRKKQELLSKTGQWINKTAAQQDGFIRRIEPDGSSDISQHPIVDPHDTTDKRPKLERTRSAAEKENLPMQRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGNFGGVQGVQTVLSPGDLQIHANNPVNWQTSADNTRLIGHMILRKYYDGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYGANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLSDTANDRKKGGGVDQERSPKGGSGMGKKSNSTSQLSATGRKRRMGFGKKGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQFFGDGAGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIASLDSLKL
Protein: Small ribosomal subunit protein eS17y (40S ribosomal protein S17-2) (Q9SJ36)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS28x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein eS19z
- Small ribosomal subunit protein eS1z
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein eS21z
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS1y
Sequence:
MGRVRTKTVKKSSRQVIEKYYSRMTLDFHTNKKILEEVAIIPSKRLRNKIAGFSTHLMKRIQKGPVRGISLKLQEEERERRMDFVPDESAIKTDEIKVDKETLEMLASLGMSDTSGISAVEPQQAMAPIAAFGGRAPRRY
Protein: Profilin-2 (Profilin II) (P26200)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Protein VASP homolog
- Cofilin-1A
- Formin-H
- HP domain-containing protein
- Severin
- Actin related protein
- Exportin-6
- Adenylyl cyclase-associated protein
Sequence:
MTWQAYVDNNLLGAGFASAALLGAADGSVWAHSAGFNVAEGKAITALFQKDGAAFATGIHVAGKKYMAIKSDTRSAYGKLGAGGVVCVKTLTCIIVAVYDDKLQPGAAANIAEKLADYLIDNNC
Protein: Protein ZEO1 (Zeocin resistance protein 1) (Q08245)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts antagonistically to MID2 in signaling cell wall stress to the PKC1-MPK1 cell integrity pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12949174}; Peripheral membrane protein {ECO:0000269|PubMed:12949174}.
Interaction partners:
- mRNA-binding protein PUF2
- Cell wall integrity sensor MID2
Sequence:
MSEIQNKAETAAQDVQQKLEETKESLQNKGQEVKEQAEASIDNLKNEATPEAEQVKKEEQNIADGVEQKKTEAANKVEETKKQASAAVSEKKETKKEGGFLKKLNRKIASIFN
Protein: Transmembrane protein (F4KDI6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- UDP-N-acetylglucosamine transporter ROCK1
- Probable beta-1,3-galactosyltransferase 8
- Cytochrome P450 superfamily protein
- Cytochrome P450 86A4
- Cytochrome P450 86A7
- Probable beta-1,4-xylosyltransferase IRX9H
- Cytochrome P450 86A8
- Tetraketide alpha-pyrone reductase 1
- Cytochrome P450 704B1
- Cytochrome P450 86B1
Sequence:
MRRFGAGNRSVSKLVLTICVAILFIPSLSYGASQGNRKTAKSSVFSLFNLRDKSRFWSESVFRTDFDDLESSVHSNSGVLNYTKSGNIASYLELMEVDSVYLPVPVNFIFIGFEGKGNQDFKLRPEELERWFNKLDHMFEHTRVPQIKEVLNPFYKINIEKEVQHHLPIISRVNYNFSVHAIQMGEKVTSVIEHAIKVLARKDDVATNKDEESALLQVDAEMMEFIFTSLVEYFHLEDAYNLFILNPKHDNKKAKYGYRRGFSESEISYLKENKEILKNLLQSGKPSENILAFDMVRKPLYDRHPMLKFSWTNAEETDTAEWFNACQDALNKLEQLSLGKDAAELIQSKVLQLLRGKNEDMKVFLEKDLRAGDFSNLNAECLTDIWIGKGRWAFIDLTAGPFSWGPSVGGEGVRTELSLPNVGTTIGAVAEISEDEAEDKLQTAIQDKFSVFGENDHQAVDILLAEIDVYELFAFKHCKGRKVKLALCEELDERMRDLKTELQSFDGEEYDETHKRKAMDALRRMESWNLFSDEREEFQNYTVARDTFLAHLGATLWGSMRHIISPSVADGAFHHYEKISFQLVFITQEKVRQIKQLPVDLKALMDGLSSLLLPSQKPLFSQHMLTLSEDPALAMAFSVARRAAAVPLLLVNGTYRKTVRSYLDSSILQYQLQRVNDHTSLKGGHAHSRSTLEIPIFWLISGDPLLIDKHYQAKALSNMVVVVQSEASSWESHLQCNGRSLLWDLRSPVKAAMASVAEHLAGLLPLHLVYSVAHESAIEDWTWSVGCNPFSVTSQGWLLSQFQSDTIARSYMITALEESIQAVNSGIHLLRLERTNKKTFKLFQSRERELMNKYKYVVSLWRRLSNVAGETRYGDAMRFLHTLEEATSSFVREVNATVGVLHPIHCTKERKVKVEVDMTTIPAFIIVLILLYAVLRPRAPKPKIN
Protein: dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (Thymidine diphospho-4-keto-rhamnose 3,5-epimerase) (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase) (dTDP-L-rhamnose synthase) (A0QSK5)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage.
Interaction partners:
- dTDP-glucose 4,6-dehydratase
- dTDP-4-dehydrorhamnose reductase
- Glucose-1-phosphate thymidylyltransferase
- Glucose-1-phosphate thymidylyltransferase
- dTDP-4-dehydrorhamnose 3,5-epimerase
- NAD dependent epimerase/dehydratase family protein
- NAD-dependent epimerase/dehydratase
- dTDP-RhA:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl transferase
- UDP-galactopyranose mutase
- Glycosyl transferase, group 2 family protein, putative
Sequence:
MTARELSIAGAWEITPVLRTDSRGLFFEWFTDAGFTEFAGHQFDMRQANCSVSARGVLRGVHFAQVPPSQAKYVTCVRGAVFDVVVDIRVGSPTFGQWDAVLLDDKDRRSIYISEGLGHAFLALDDDSTVMYLCSAPYAPQREHTVRPTDFGIEWPEVPELILSDRDAQAPSLAEAQAAGVLPTWADCQAFVETLRRNLVS
Protein: Serine/threonine-protein kinase/endoribonuclease IRE1b (Endoplasmic reticulum-to-nucleus signaling 1-1) (Inositol-requiring protein 1-1) (AtIRE1-1) (Serine/threonine-protein kinase/endoribonuclease IRE1-1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] (Q93VJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices bZIP60 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator which then induces transcription of UPR target genes. Involved in organ growth regulation. Plays a role in plant immunity and abiotic stress responses. Required for ER stress-induced autophagy.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11706177}; Single-pass type I membrane protein {ECO:0000269|PubMed:11706177}.
Interaction partners:
- Heat shock 70 kDa protein BIP3
- Heat shock 70 kDa protein BIP1
- Heat shock 70 kDa protein BIP2
- bZIP transcription factor 60
- bZIP transcription factor 28
- bZIP transcription factor 17
- Subtilisin-like protease SBT6.1
- Probable serine/threonine protein kinase IRE
- Membrane-bound transcription factor site-2 protease homolog
- DnaJ protein ERDJ3B
Sequence:
MRGSALLDLILFLLVSPLAHSFKGSEISKFYDKSISNQISQSDRESGYVLVSTVDGSISLVDMSSQKLDWTFHTNEPIYSSYQAPHYHYTTDEERSSVLGDDFYMDCDKDWRLYNSSVRKGKRVNEIVDASEFIGTLPYTSTDRIVLGKKDTSVFLLDWKTGKLVKRYRMDELYSNTVVENDKEKAIVLSKEAPLLFGSGFKKSEDFPELVYIERKDFKIQCISKFGDVLWSVSYAKMEAKLQNHESVQFISGLSSSVGKNQFPLSYTTSVPMVQLRNVKYETLFPRLGFLDEALYLPFQDRKPNQLAIGDGNQLTLPGNKEAEEVLSLPLPETVISQITDIIDGSTKQAGFASKFSGLIVLIFGFCVTMLSVCGLFFYRLRQSIRIKEPYVSEVPIATPKKKKSKKNGTTKAVHKKENGFISGGNKDPSHEENEKRLLTAFPGLNNSSAEGYRVGKLFVSNKEIAKGSNGTVVLEGSYEGRLVAVKRLVQSHHDVAQKEILNLMASDKHSNIVRWYGVDQDEHFIYISLELCACSLNDLIYASSALLESPMASSSIHSIQINPIFENGKGVELWKENGHPSPVLLKLMRDIVAGLVHLHDIGIVHRDLKPQNVLIVKNSSLCAKLSDMGISKRLPADTSALTRNSTGLGSGSSGWQAPEQLRNERQTRAVDLFSLGCVLFFCMTGGKHPYGDNYERDVNVLNDQKDLFLIESLPEAVHLLTGLLNPDPNLRPRAQDVMHHPLFWNSDMRLSFLRDASDRVELENREEGSQLLAALESTAAVTLNGRWDEKLDSIFLDNIGRYRRYKFDSIRDLLRVIRNKLNHYRELPKELQELLGSVPEGFERYFSSRFPKLLIQVYTVLFDYCNNEEFFFKYSKTTVF
Protein: DnaJ homolog subfamily C member 4 (Multiple endocrine neoplasia type 1 candidate protein number 18 homolog) (Q9D844)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- DnaJ homolog subfamily C member 11
Sequence:
MPSLLLQLPLRLCRLWPHSLSIRLLTAATGQRSVPTNYYELLGVHPGASAEEIKRAFFTKSKELHPDRDPGNPALHSRFVELNEAYRVLSREESRRNYDHQLHSASPPKSSGSTAEPKYTQQTHSSWEPPNAQYWAQFHSVRPQGPESRKQQRKHNQRVLGYCLLLMVAGMGLHYVAFRKLEQVHRSFMDEKDRIITAIYNDTRARARANRARIQQERQQRQQPRAEPSLPPESSRIMPQDTSP