wanglab/gogpt-training-data huggingface dataset:
Protein: CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF-IL6-beta) (NF-IL6-beta) (P49716)
Organism: Homo sapiens (Human)
Function: Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB.
Subcellular location: Nucleus {ECO:0000305|PubMed:16397300}.
Interaction partners:
- CCAAT/enhancer-binding protein beta
- Krueppel-like factor 5
- Peroxisome proliferator-activated receptor gamma
- CUGBP Elav-like family member 1
- CUGBP Elav-like family member 3
- CUGBP Elav-like family member 2
- CUGBP Elav-like family member 4
- Mothers against decapentaplegic homolog 4
- Troponin T, cardiac muscle
- CUGBP Elav-like family member 5
Sequence:
MSAALFSLDGPARGAPWPAEPAPFYEPGRAGKPGRGAEPGALGEPGAAAPAMYDDESAIDFSAYIDSMAAVPTLELCHDELFADLFNSNHKAGGAGPLELLPGGPARPLGPGPAAPRLLKREPDWGDGDAPGSLLPAQVAACAQTVVSLAAAGQPTPPTSPEPPRSSPRQTPAPGPAREKSAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQLTRDLAGLRQFFKQLPSPPFLPAAGTADCR
Protein: Transducin family protein / WD-40 repeat family protein (Q0WVR3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MILDEKNRKNLVFLILQFFDEEGYEESLHLLEQDSGVFFDFSYLSNAILNGNWKDADDYLSAFTSPEANTFSRKMFFGLFKLKFSEAPDRSGGSEAVKIFSKDLRRIPVLKDDSFDDLVEVIAVDDMRIPEETCCVDKAPGRAKLCVDLHKLAESNPSLRGKLDFPSLNKSALLALISLLCPNCSRRKGGLKEDLICLILQFLYEAKYKNTLHKLEQETKVFFNLNYLAEVMKLGEYGKAEEYLGAFTNWEDNKYSKAMFLELQKLICLQSTEWEVATPSGSLDNMSLKIKLHASVAMLAKKNPVLKDELKFPSMEKSRLLTLVKQTMDWWTCNNTSSLENVPVVSYLCGTPSSMKFFFKKTVPRKKKPNEIKDPSQCNALVLPDCFSEEKIARLTYSPSGDYILALAEDATHKLWTWSSSQNEFCKENVYPKPRLHQPQSGKTMENEMATSVQKSTSCFAVKGSYLFSTSGGKIAVFDLKNFEKVASFGSPTPMATYFIFIPGDLLAVGLDDGSIFIHCLSSRKVKEKLEGHDQKITCLAFSRCFNVLVSSDSDGKLCLWSTKSWVKLTSKNSTRKFCNRSNLESTSLVTHIQFDPYQIELLVVHDGWIGLYEVRTLDCRLQWIPDASDPAITSATYSSDGEIIYVGFRCGSIKIVDSKTFMTLCQINLTSFTQLSTSNISLEVYPTVVAAHPSHPNQISAGLSNGKVIVLQPLWSGGWGEAAPLEDNGDYSNDSDHSY
Protein: F-box protein SKIP14 (SKP1-interacting partner 14) (Q9LU91)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Interaction partners:
- U-box domain-containing protein 30
- Ketose-bisphosphate aldolase class-II family protein
- SEC1 family transport protein SLY1
- Zinc finger CCCH domain-containing protein 1
- Triosephosphate isomerase, cytosolic
- Triosephosphate isomerase, chloroplastic
- Mediator of RNA polymerase II transcription subunit 15a
- Rhodanese-like domain-containing protein 4, chloroplastic
- Scarecrow-like protein 8
- Phosphoglycerate kinase 1, chloroplastic
Sequence:
MALNFSHRPFSSHLSEEPMMIANGNWCSSFDNGRKNTGGDASSVDILDVLPSDPFGMDINNTFTAITGWLEDLEDDYNNQYGRRRRDDIWIGDGNRQQLFAGLSFFWNNAMQFQSSGYSYGSESLFGGAFDGSLFSTCKFPESSGENNGFGGALDGDGSCHGAFISASSVDEVLSHENARNGEVVGSSDRCNNGEEDAYVHPAIGFCLYHLRGKDLLSVSMVCKSLHTTVCDDTLLWKHIHICRPLNEKITEEALLHLTERAQGTMQCLRIVDCCRITDDCLKRVVARNRQVVKIGVPGCTRITIDGILSVLRDLKSAGKLQVKHLQLRGLFGVTKDHYDELIDLLNIDNKVKQTIQKPRFYHRGEACVSCDDDRALDIEMCPKCQNFKLVYDCPAEDCKGKKKGSEECRACSLCIQRCYHCGRCIIDTEYEEMFCLELLCAVCSKPTPKLTL
Protein: Phosphoglucan, water dikinase, chloroplastic (EC 2.7.9.5) (Q6ZY51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the incorporation of phosphate into starch-like phospho-alpha-glucan, mostly at the C-3 position of glucose units. Required for starch degradation, suggesting that the phosphate content of starch regulates its degradability.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:15618411, ECO:0000269|PubMed:15686522}. Note=Starch granules during starch mobilization in darkness.
Interaction partners:
- 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic
- Isoamylase 3, chloroplastic
- Alpha-glucan phosphorylase 2, cytosolic
- 4-alpha-glucanotransferase DPE2
- Phosphoglucan phosphatase DSP4, chloroplastic
- Isoamylase 2, chloroplastic
- Phosphoglucan phosphatase LSF1, chloroplastic
- Alpha-glucan phosphorylase 1
- Phosphoglucan phosphatase LSF2, chloroplastic
- Isoamylase 1, chloroplastic
Sequence:
MESIGSHCCSSPFTFITRNSSSSLPRLVNITHRVNLSHQSHRLRNSNSRLTCTATSSSTIEEQRKKKDGSGTKVRLNVRLDHQVNFGDHVAMFGSAKEIGSWKKKSPLNWSENGWVCELELDGGQVLEYKFVIVKNDGSLSWESGDNRVLKVPNSGNFSVVCHWDATRETLDLPQEVGNDDDVGDGGHERDNHDVGDDRVVGSENGAQLQKSTLGGQWQGKDASFMRSNDHGNREVGRNWDTSGLEGTALKMVEGDRNSKNWWRKLEMVREVIVGSVEREERLKALIYSAIYLKWINTGQIPCFEDGGHHRPNRHAEISRLIFRELEHICSKKDATPEEVLVARKIHPCLPSFKAEFTAAVPLTRIRDIAHRNDIPHDLKQEIKHTIQNKLHRNAGPEDLIATEAMLQRITETPGKYSGDFVEQFKIFHNELKDFFNAGSLTEQLDSMKISMDDRGLSALNLFFECKKRLDTSGESSNVLELIKTMHSLASLRETIIKELNSGLRNDAPDTAIAMRQKWRLCEIGLEDYFFVLLSRFLNALETMGGADQLAKDVGSRNVASWNDPLDALVLGVHQVGLSGWKQEECLAIGNELLAWRERDLLEKEGEEDGKTIWAMRLKATLDRARRLTAEYSDLLLQIFPPNVEILGKALGIPENSVKTYTEAEIRAGIIFQISKLCTVLLKAVRNSLGSEGWDVVVPGSTSGTLVQVESIVPGSLPATSGGPIILLVNKADGDEEVSAANGNIAGVMLLQELPHLSHLGVRARQEKIVFVTCDDDDKVADIRRLVGKFVRLEASPSHVNLILSTEGRSRTSKSSATKKTDKNSLSKKKTDKKSLSIDDEESKPGSSSSNSLLYSSKDIPSGGIIALADADVPTSGSKSAACGLLASLAEASSKVHSEHGVPASFKVPTGVVIPFGSMELALKQNNSEEKFASLLEKLETARPEGGELDDICDQIHEVMKTLQVPKETINSISKAFLKDARLIVRSSANVEDLAGMSAAGLYESIPNVSPSDPLVFSDSVCQVWASLYTRRAVLSRRAAGVSQREASMAVLVQEMLSPDLSFVLHTVSPADPDSNLVEAEIAPGLGETLASGTRGTPWRLASGKLDGIVQTLAFANFSEELLVSGTGPADGKYVRLTVDYSKKRLTVDSVFRQQLGQRLGSVGFFLERNFGCAQDVEGCLVGEDVYIVQSRPQPL
Protein: Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC) (Q15814)
Organism: Homo sapiens (Human)
Function: Tubulin-folding protein; involved in the final step of the tubulin folding pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12417528}. Note=Detected predominantly in the photoreceptor connecting cilium.
Interaction partners:
- Tubulin-specific chaperone D
- ADP-ribosylation factor-like protein 3
- Tubulin-specific chaperone E
- Tubulin-folding cofactor B
Sequence:
MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFVRERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGPSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQWD
Protein: Rhomboid-like protein (Q38ED9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLRYSPMHLIKTLRGPRVTGAPARFLRDNGVSLVGPARSTFLMMYRMQGNQNVRMGAGAYKDSCRTFCSSAVLRDPKKPSGQLVGTHQVQQRNEGDKGGDEEQKQEDPFGGNAGAGYLPFPPPFHTINVVMLLFLANVITYFLMNFSGSDDLRDFIVEHFTLSHENAGRIYPFFTNALYQENLLQLLIDCWLLWEFGKTMLGFLGNARMTFFASLCTLGGGLIHVARQNFELYYGMDPLEVRGRCYGPNPFILGLVGVEGIIFRHLNFIQQPPVPFLVLTAFVMVIDVWRIFTTKPEEHGAATGGALVAYVFWALPTRMLGLDKLTAAL
Protein: N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) (EC 3.5.1.25) (O34450)
Organism: Bacillus subtilis (strain 168)
Function: Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate.
Interaction partners:
- Glucosamine-6-phosphate deaminase 2
- Glucosamine-6-phosphate deaminase 1
- N-acetylmuramic acid 6-phosphate etherase
- PTS system glucosamine-specific EIICBA component
- PTS system N-acetylglucosamine-specific EIICB component
- HTH-type transcriptional repressor NagR
- Glutamine--fructose-6-phosphate aminotransferase
- Phosphoglucosamine mutase
- Uncharacterized protein YbcM
- Bifunctional protein GlmU
Sequence:
MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYSKEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQEHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGASHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKLILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKEADQI
Protein: Homeobox protein VENTX (VENT homeobox homolog) (VENT-like homeobox protein 2) (O95231)
Organism: Homo sapiens (Human)
Function: May be involved in ventralization.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transducin-like enhancer protein 4
- Transducin-like enhancer protein 1
- TLE family member 5
- Macrophage colony-stimulating factor 1 receptor
- Cellular tumor antigen p53
- Interleukin-6
- Lymphoid enhancer-binding factor 1
- Transducin-like enhancer protein 3
- Transcription factor 7-like 2
Sequence:
MRLSSSPPRGPQQLSSFGSVDWLSQSSCSGPTHTPRPADFSLGSLPGPGQTSGAREPPQAVSIKEAAGSSNLPAPERTMAGLSKEPNTLRAPRVRTAFTMEQVRTLEGVFQHHQYLSPLERKRLAREMQLSEVQIKTWFQNRRMKHKRQMQDPQLHSPFSGSLHAPPAFYSTSSGLANGLQLLCPWAPLSGPQALMLPPGSFWGLCQVAQEALASAGASCCGQPLASHPPTPGRPSLGPALSTGPRGLCAMPQTGDAF
Protein: p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15) (Q9DCE5)
Organism: Mus musculus (Mouse)
Function: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NWT1}.
Interaction partners:
- Ribosome production factor 2 homolog
- Ribosome biogenesis protein BRX1 homolog
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Probable rRNA-processing protein EBP2
- GTP-binding protein 4
- mRNA turnover protein 4 homolog
- Ribosome biogenesis regulatory protein homolog
- Probable ribosome biogenesis protein RLP24
- DDB1- and CUL4-associated factor 13
- Ribosomal L1 domain-containing protein 1
Sequence:
MELVAGSYEQVLFGFTVQRGPAKSGHQETWTPVADFTHHSHTASLSVLASNSRYVVSGSKDETIHIYDMKRKVEHGALVHHAGTVTCLKFHGNQHLISGAEDGHICIWDVKRWKCLKTFKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLIEGRSAFIKNIKENAHIVEWSPSGGKYIVVVQNKVDVYRLGTASVSGTITNGKRISSVTFLSDSVLAVAGDEEVVRIFDCDSLECLCEFRAHENRVKDMVSFEVPDHHVLVTASNDGFIKMWTLPQDKKVPPSLLCEAKTGARLTCLTVWLDRAANGMASLPPAAEPCPDQPKTIEKESGDTVQEETSEPNSEKSDVSGDSKQPTKGNSPVTAKKRKMATMSEKKRKKKM
Protein: Protein esc1 (Q04635)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the sexual differentiation process. Modulate the ability of the cell to differentiate in response to the nitrogen starvation signal; in particular in response to decreases in the level of cellular cAMP.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Lap-Emerin-Man domain protein 2
Sequence:
MSSYALPSMQPTPTSSIPLRQMSQPTTSAPSNSASSTPYSPQQVPLTHNSYPLSTPSSFQHGQTRLPPINCLAEPFNRPQPWHSNSAAPASSSPTSATLSTAAHPVHTNAAQVAGSSSSYVYSVPPTNSTTSQASAKHSAVPHRSSQFQSTTLTPSTTDSSSTDVSSSDSVSTSASSSNASNTVSVTSPASSSATPLPNQPSQQQFLVSKNDAFTTFVHSVHNTPMQQSMYVPQQQTSHSSGASYQNESANPPVQSPMQYSYSQGQPFSYPQHKNQSFSASPIDPSMSYVYRAPESFSSINANVPYGRNEYLRRVTSLVPNQPEYTGPYTRNPELRTSHKLAERKRRKEIKELFDDLKDALPLDKSTKSSKWGLLTRAIQYIEQLKSEQVALEAYVKSLEENMQSNKEVTKGT
Protein: Uncharacterized protein C13G6.05c (Q09784)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Transport protein particle subunit bet3
- Transport protein particle subunit bet5
- Transport protein particle subunit trs23
- Transport protein particle 20 kDa subunit
- Uncharacterized protein C15A10.12c
- Transport protein particle subunit trs31
- Transport protein particle subunit trs120
- Uncharacterized protein CC285.14
- GTP-binding protein ypt1
- Transport protein particle subunit trs85-2
Sequence:
MIVHQQLPMSVNVASLDFLLIELVHTAKRLAEDRKKKSSSEKSIESDFQMLESIGFQVGRKITERLLLNRNRITETTDVMRFLCRELWPIVFRKPLDNLKTNRRGIFVLTDTYFYWFTKMTAMTGTEMAQITTPYFYFPSGFIRGVVYTFGYSAQVIAQCPNLPTCIFHVKFSPNPTQTSPGKPSTSESSQTDTSTRPANSQTPTTTRASSYTTLVSTSNQVSNEAEASAVETSANQAQNTEDATENEDRLPS
Protein: NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) (Q13506)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Early growth response protein 1
- E3 SUMO-protein ligase EGR2
- Early growth response protein 3
- Early growth response protein 4
Sequence:
MAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLPVSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATESEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHLTLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEDGFPDFQDSVQTLFQQARAKSEELAALSSQQPEKVMAKQMEFLCNQAGYERLQHAERRLSAGLYRQSSEEHSPNGLTSDNSDGQGERPLNLRMPNLQNRQPHHFVVDGELSRLYPSEAKSHSSESLGILKDYPHSAFTLEKKVIKTEPEDSR
Protein: NADH-ubiquinone oxidoreductase chain 4L (EC 7.1.1.2) (NADH dehydrogenase subunit 4L) (ND4L) (P03901)
Organism: Homo sapiens (Human)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH-ubiquinone oxidoreductase chain 5
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH-ubiquinone oxidoreductase chain 6
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 3
Sequence:
MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
Protein: Ras-related protein Rab-21 (Q7PLE9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037868}; Lipid-anchor {ECO:0000256|ARBA:ARBA00037868}.
Interaction partners:
- Rabaptin-5-associated exchange factor for Rab5
- Receptor-mediated endocytosis protein 6 homolog
- Rab GDP dissociation inhibitor
- SET domain binding factor, isoform A
- Vesicle-associated membrane protein 7
- Rab proteins geranylgeranyltransferase component A
- Ras-related protein Rab5
Sequence:
MSSSRTRNGPTLNFKAVLLGEGCVGKTSLVLRYMEDRFNAQHLSTLQASFVSRKMSLEDGRRAQLNIWDTAGQERFHALGPIYYRGSDGALLVYDITDRDSFQKVKSWVRELRQMRGTEIALIIVGNKTDLEEQRAVTHDEALQYARTVGAQYVETSAKENEGVAELFELLTQLMLEQLSQRQPDASPLRLQNPDTDNLNNSDDSEAPDPGDPAGQRSCCGI
Protein: Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22) (O75935)
Organism: Homo sapiens (Human)
Function: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:9722614}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9722614}. Cleavage furrow {ECO:0000269|PubMed:9722614}. Midbody {ECO:0000269|PubMed:9722614}. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.
Interaction partners:
- Dynactin subunit 6
- Dynactin subunit 2
- Dynactin subunit 1
- Alpha-centractin
- Dynactin subunit 5
- Dynactin subunit 4
- Actin-related protein 10
- Beta-centractin
- Cytoplasmic dynein 1 intermediate chain 2
- Cytoplasmic dynein 1 heavy chain 1
Sequence:
MAGLTDLQRLQARVEELERWVYGPGGARGSRKVADGLVKVQVALGNISSKRERVKILYKKIEDLIKYLDPEYIDRIAIPDASKLQFILAEEQFILSQVALLEQVNALVPMLDSAHIKAVPEHAARLQRLAQIHIQQQDQCVEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAATQVKPAEE
Protein: 40S ribosomal protein S15 (Q8IDB0)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Large ribosomal subunit protein eL22
- Large ribosomal subunit protein eL42
- 60S ribosomal protein L39
- 40S ribosomal protein S11
- 40S ribosomal protein S29, putative
- 40S ribosomal protein S15A, putative
- 60S ribosomal protein L24, putative
- 60S ribosomal protein L21
- 60S ribosomal protein L2
- 60S ribosomal protein L6, putative
Sequence:
MGRMYGKGKGISSSTLPYKRKQPSWLKQKPSEIEDAIIKLAKKGQTPSQIGATLRDNYGIPQVKSVTGNKILRILRAQGIATTIPEDLYFLIKKAVSMRKHLEKNKKDKDCKFRLILTESKIHRISRYYKRKKLLPSNWKYQSSTASALIA
Protein: Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1) (Q15392)
Organism: Homo sapiens (Human)
Function: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:22010141}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:11007892}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- 7-dehydrocholesterol reductase
- Lanosterol 14-alpha demethylase
- Methylsterol monooxygenase 1
- Lathosterol oxidase
- Lanosterol synthase
- 3-beta-hydroxysteroid-Delta
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Delta
- Delta
- Sterol O-acyltransferase 2
Sequence:
MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH
Protein: Keratin-associated protein 21-1 (Q3LI58)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
- Keratin-associated protein 21-2
- Keratin-associated protein 21-3
- Keratin-associated protein 6-3
Sequence:
MCCNYYGNSCGYGSGCGCGYGSGSGCGCGYGTGYGCGYGCGFGSHYGCGYGTGYGCGYGSGSGYCGYRPFCFRRCYSSC
Protein: Na,K-ATPase alpha subunit isoform 1b/i (Q5IRA1)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
KNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGTCFDKSSATWASLARVAGLCNRAVFLAEQNNVPILKRDVAGDASESALLKCIELCCGSVKDMREKYSKIAEIPFNSTNKYQLSIHKNIMAGESKHLLVMKGAPERILDRCSTILIQGKEQSLDDELKEAFQNAYEELGGLGERVLGFCHFQLPDDQFAEGFNFDCEEVNFPTENLCFVGLM
Protein: Transcription factor unc-3 (Uncoordinated protein 3) (CEO/E) (Q93705)
Organism: Caenorhabditis elegans
Function: Transcription factor. Involved in motor neuron fate determination and maintenance, acting as an activator of gene expression in a subset of motor neurons. May act in concert with GFI1 homolog pag-3 in motor neuron fate determination. Required to maintain the expression of transcriptional repressors bnc-1 and cfi-1, which play roles in the cell fate of motor neurons. May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ubiquitin fusion degradation protein 1 homolog
- Ubiquitin fusion degradation protein 3 homolog
- Homeobox protein unc-30
- Homeobox protein unc-42
- AT-rich interactive domain-containing protein cfi-1
- LIM/homeobox protein ttx-3
- Zinc finger protein GFI1 homolog pag-3
- Homeobox protein ceh-10
- Transcription factor unc-86
- High-affinity choline transporter 1
Sequence:
MSLTAPLRAGQMNFYDEPYNPVLNLHIQPSVKDENQRSTWPIIDTSNTSTQIARAHFEKHPPNNLRKSNFFHFVIALYDRNSQPIEVERTQFAGFVEKEKEVDGQDTRNGIHYRLSLMFQNGIRSEHDLFVRLIDSSTKQAITYEGQDKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVLCSSARIDGPLLAVSDNMFVHNNSKHGRRTKRTDASDDSEYSESAELPSSVPVIKALFPSEGWIQGGTQVVLIGENFFEGLQVAFGTASPNWGESVQLISPHAIRVTTPPKHSAGPVDVTLQYKSKTYSRGTPLRFSYITLAEPGIEYGFQRLQKLLPKYPGDPERLPKDQILKRAAELAEALYNRTSTESLSSYYHTQFDATSDYAARTHTSPRSTLPYGAGPPALSSAVYQTSYPTVNATPAANFLNTQTGFATFGAVNPFAATLQSSSRLS
Protein: Cell division control protein 3 (P32457)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
Subcellular location: Membrane; Peripheral membrane protein. Bud neck. Note=Present at the bud neck during cell division. Probably interacts with phosphoinosides such as phosphatidylinositol 4-phosphate or phosphatidylinositol 5-phosphate.
Interaction partners:
- Seventh homolog of septin 1
- Cell division control protein 12
- Cell division control protein 11
- Cell division control protein 10
- Probable serine/threonine-protein kinase KCC4
- Serine/threonine-protein kinase GIN4
- Sporulation-regulated protein 28
- Sporulation-regulated protein 3
- Probable serine/threonine-protein kinase HSL1
- Bud neck protein 5
Sequence:
MSLKEEQVSIKQDPEQEERQHDQFNDVQIKQESQDHDGVDSQYTNGTQNDDSERFEAAESDVKVEPGLGMGITSSQSEKGQVLPDQPEIKFIRRQINGYVGFANLPKQWHRRSIKNGFSFNLLCVGPDGIGKTTLMKTLFNNDDIEANLVKDYEEELANDQEEEEGQGEGHENQSQEQRHKVKIKSYESVIEENGVKLNLNVIDTEGFGDFLNNDQKSWDPIIKEIDSRFDQYLDAENKINRHSINDKRIHACLYFIEPTGHYLKPLDLKFMQSVYEKCNLIPVIAKSDILTDEEILSFKKTIMNQLIQSNIELFKPPIYSNDDAENSHLSERLFSSLPYAVIGSNDIVENYSGNQVRGRSYPWGVIEVDNDNHSDFNLLKNLLIKQFMEELKERTSKILYENYRSSKLAKLGIKQDNSVFKEFDPISKQQEEKTLHEAKLAKLEIEMKTVFQQKVSEKEKKLQKSETELFARHKEMKEKLTKQLKALEDKKKQLELSINSASPNVNHSPVPTKKKGFLR