wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein orf173 (Uncharacterized protein orf173c) (Q2F956)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MSGGAKRSSLNQRFYEIEIDSFLDIWIDGWIYLDIQISFAISPKSLIWPGNKALLWAQEAKGMSSAASPPHFFISPCPFRMRFARHWRFALLLFLHWRVRMDFAVLSQRKWKGLYHIEMSIRFPPQMRWGISHLCPFIFMKGIKARPGSRRSNNRRGAPQYTIARSNWESYYT
Protein: Jeltraxin (Egg jelly pentraxin) (Q9PTT2)
Organism: Lepidobatrachus laevis (Budgett's frog)
Function: Calcium-dependent beta-galactose specific lectin.
Subcellular location: Secreted {ECO:0000269|PubMed:14596590}.
Interaction partners:
Sequence:
MKGLVIFFCLFYGCHVAGATGKTIMLFPQKTDTDYVTLKPTERVLNQITVCLKSYTELIKEHSLFSLAMQGSGKDNTLLIYPYPPNNISISIHNEDIYFKVDPEVLQWKRTCVTWDSKTGLLQLWINGKLYPRRITKSRSPIGPQISVILGQEQDSYGGSFDINQAFVGEMSDVNVWDYVLPPENIKAYFSDDYTLDGNFYSWDGGNYTINGLIVVLRNQFIPKL
Protein: Non-selective voltage-gated ion channel VDAC3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3) (Q9Y277)
Organism: Homo sapiens (Human)
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). Involved in male fertility and sperm mitochondrial sheath formation (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21796}. Membrane {ECO:0000269|PubMed:27641616}. Note=May localize to non-mitochondrial membranes. {ECO:0000269|PubMed:27641616}.
Interaction partners:
- Non-selective voltage-gated ion channel VDAC2
- Non-selective voltage-gated ion channel VDAC1
- ADP/ATP translocase 1
- Glycerol kinase 2
- Glycerol kinase
- ADP/ATP translocase 2
- ADP/ATP translocase 3
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Cytochrome c
- Translocator protein
Sequence:
MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA
Protein: Calponin-homology (CH) domain-containing protein (G5EBX1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTTSNVELIPIYTDWANRHLSKGSLSKSIRDISNDFRDYRLVSQLINVIVPINEFSPAFTKRLAKITSNLDGLETCLDYLKNLGLDCSKLTKTDIDSGNLGAVLQLLFLLSTYKQKLRQLKKDQKKLEQLPTSIMPPAVSKLPSPRVATSATASATNPNSNFPQMSTSRLQTPQSRISKIDSSKIGIKPKTSGLKPPSSSTTSSNNTNSFRPSSRSSGNNNVGSTISTSAKSLESSSTYSSISNLNRPTSQLQKPSRPQTQLVRVATTTKIGSSKLAAPKAVSTPKLASVKTIGAKQEPDNSGGGGGGMLKLKLFSSKNPSSSSNSPQPTRKAAAVPQQQTLSKIAAPVKSGLKPPTSKLGSATSMSKLCTPKVSYRKTDAPIISQQDSKRCSKSSEEESGYAGFNSTSPTSSSTEGSLSMHSTSSKSSTSDEKSPSSDDLTLNASIVTAIRQPIAATPVSPNIINKPVEEKPTLAVKGVKSTAKKDPPPAVPPRDTQPTIGVVSPIMAHKKLTNDPVISEKPEPEKLQSMSIDTTDVPPLPPLKSVVPLKMTSIRQPPTYDVLLKQGKITSPVKSFGYEQSSASEDSIVAHASAQVTPPTKTSGNHSLERRMGKNKTSESSGYTSDAGVAMCAKMREKLKEYDDMTRRAQNGYPDNFEDSSSLSSGISDNNELDDISTDDLSGVDMATVASKHSDYSHFVRHPTSSSSKPRVPSRSSTSVDSRSRAEQENVYKLLSQCRTSQRGAAATSTFGQHSLRSPGYSSYSPHLSVSADKDTMSMHSQTSRRPSSQKPSYSAAALNASGMSRSMILLESLSPRPPRRHQSPADSCIITASPSAPRRSHSPRGPTARIPLSLASSPVHVNNNWGSYSARSRGGSSTGIYGETFQLHRLSDEKSPAHSAKSEMGSQLSLASTTAYGSLNEKYEHAIRDMARDLECYKNTVDSLTKKQENYGALFDLFEQKLRKLTQHIDRSNLKPEEAIRFRQDIAHLRDISNHLASNSAHANEGAGELLRQPSLESVASHRSSMSSSSKSSKQEKISLSSFGKNKKSWIRSSLSKFTKKKNKNYDEAHMPSISGSQGTLDNIDVIELKQELKERDSALYEVRLDNLDRAREVDVLRETVNKLKTENKQLKKEVDKLTNGPATRASSRASIPVIYDDEHVYDAACSSTSASQSSKRSSGCNSIKVTVNVDIAGEISSIVNPDKEIIVGYLAMPTSQSCWKDIDVSILGLFEVYLSRIDVEHQLGIDARDSILGYQIGELRRVIGDSTTMITSHPTDILTSSTTIRMFMHGAAQSRVDSLVLDMLLPKQMILQLVKSILTERRLVLAGATGIGKSKLAKTLAAYVSIRTNQSEDSIVNISIPENNKEELLQVERRLEKILRSKESCIVILDNIPKNRIAFVVSVFANVPLQNNEGPFVVCTVNRYQIPELQIHHNFKMSVMSNRLEGFILRYLRRRAVEDEYRLTVQMPSELFKIIDFFPIALQAVNNFIEKTNSVDVTVGPRACLNCPLTVDGSREWFIRLWNENFIPYLERVARDGKKTFGRCTSFEDPTDIVSEKWPWFDGENPENVLKRLQLQDLVPSPANSSRQHFNPLESLIQLHATKHQTIDNI
Protein: Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (Q08AG9)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Microsome membrane {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004174}.
Interaction partners:
Sequence:
MLLLGLLLLLPLLAGARLLWNWWKLQSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQSQ
Protein: Small GTP-binding protein Rab1 (D6XLJ6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Trafficking protein particle complex subunit
- Rab GDP dissociation inhibitor
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Transport protein particle
- Uncharacterized protein
- Transport protein particle
- Trafficking protein particle complex subunit
- Vesicle tethering protein Uso1/P115-like head domain-containing protein
- Geranylgeranyl transferase type-2 subunit beta
Sequence:
MITAASPGGDCDYIFKIIVIGDSGVGKSSLTVRLSEDVFYKDYASTIAIDFRMHQMTYMDKRVRLQIWDTAGQERFQSVATAFYRGANGVMLCFDLTHRPSFLHLEHWMERVRQQSLPGIPCLLVGCKSDEARTSRQVSKEEAMAWAKQHGMSYIDTSAKEKENVQSAFQKIAQEIFEDMKERTGKGLSPSGGAGGAGNGVRLAGNEGQKGSKRGGCC
Protein: Src substrate cortactin (Q60598)
Organism: Mus musculus (Mouse)
Function: Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q14247}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q14247}. Cell projection, ruffle. Cell projection, dendrite. Cell projection {ECO:0000250|UniProtKB:Q66HL2}. Cell membrane {ECO:0000250|UniProtKB:Q66HL2}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, podosome {ECO:0000250|UniProtKB:Q01406}. Cell junction {ECO:0000250|UniProtKB:Q66HL2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q66HL2}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q66HL2}. Cell projection, dendritic spine. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q14247}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q01406}. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers. In the presence of CTTNBP2, localizes at the cell cortex. In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft. Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity). {ECO:0000250|UniProtKB:Q14247, ECO:0000250|UniProtKB:Q66HL2}.
Interaction partners:
- Actin nucleation-promoting factor WAS
- Proto-oncogene tyrosine-protein kinase Src
- Tight junction protein 1
- Actin nucleation-promoting factor WASL
- Dynamin-2
- Cofilin-2
- Cofilin-1
- Actin-related protein 3
- Protein deacetylase HDAC6
- Actin-related protein 2
Sequence:
MWKASAGHAVSITQDDGGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDRSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSSAVGFDYKERLAKHESQQDYAKGFGGKYGVQKDRMDKNASTFEEVVQVPSAYQKTVPIEAVTSKTSNIRANFENLAKEREQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKKQTPPASPSPQPIEDRPPSSPIYEDAAPFKAEPSYRGSEPEPEYSIEAAGIPEAGSQQGLTYTSEPVYETTEAPGHYQAEDDTYDGYESDLGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
Protein: Tryptophan aminotransferase-related protein 2 (EC 2.6.1.27) (EC 2.6.1.99) (Q94A02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in auxin production. Both TAA1 and TAR2 are required for maintaining proper auxin levels in roots, while TAA1, TAR1 and TAR2 are required for proper embryo patterning. Involved in the maintenance of the root stem cell niches.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Tryptophan N-monooxygenase 1
- Probable indole-3-pyruvate monooxygenase YUCCA1
- Probable indole-3-pyruvate monooxygenase YUCCA4
- Tryptophan N-monooxygenase 2
- Aromatic aminotransferase ISS1
- Indole-3-pyruvate monooxygenase YUCCA6
- Indole-3-pyruvate monooxygenase YUCCA2
- Probable indole-3-pyruvate monooxygenase YUCCA5
- Probable indole-3-pyruvate monooxygenase YUCCA11
- Probable indole-3-pyruvate monooxygenase YUCCA8
Sequence:
MGQIPRFLSWRNMLVLSLAINFSLILKILKGDRERGDSWDRTAYVSIWPVVSTTASESSSLSSASCNYSKIEEDDDRIINLKFGDPTVYERYWQENGEVTTMVIPGWQSLSYFSDENNLCWFLEPELAKEIVRVHKVVGNAVTQDRFIVVGTGSTQLYQAALYALSPHDDSGPINVVSATPYYSTYPLITDCLKSGLYRWGGDAKTYKEDGPYIELVTSPNNPDGFLRESVVNSTEGILIHDLAYYWPQYTPITSPADHDVMLFTASKSTGHAGIRIGWALVKDRETARKMIEYIELNTIGVSKDSQLRVAKVLKVVSDSCGNVTGKSFFDHSYDAMYERWKLLKQAAKDTKRFSVPDFVSQRCNFFGRVFEPQPAFAWFKCEEGIVDCEKFLREEKKILTKSGKYFGDELSNVRISMLDRDTNFNIFLHRITSSFNSTL
Protein: HTH-type transcriptional regulator PrpR (Propionate regulator) (PRPR) (O06581)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate. PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor. During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA, which encodes the DnaA initiator protein responsible for initiating chromosomal replication. It is possibly involved in the regulation of genes responsible for controlling cholesterol utilization.
Interaction partners:
- 2-methylcitrate dehydratase
- 2-methylcitrate synthase
- Isocitrate lyase
Sequence:
MTRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLSTSYVNQLENDQRPITVPVLLLLTERFDLSAQYFSSDSDARLVADLSDVFTDIGVEHAVSGAQIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRATAETELPPARPMPFEEVRDFFYDRNNYIHDLDMAAERMFTESGMRTGGLDIQLAELMRDRFGISVVIDDNLPDTAKRRYHPDTKVLRVAHWLMPGQRAFQIATQLALVGQSDLISSIVATDDQLSTEARGVARIGLANYFAGAFLLPYREFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPFIFVRTDKAGNISKRQSATAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRSYFWVAKTTAADGLGYLGPHKNFAVGLGCDLAHAHKLVYSTGVVLDDPSTEVPIGAGCKICNRTSCAQRAFPYLGGRVAVDENAGSSLPYSSTEQSV
Protein: Heparan sulfate 2-O-sulfotransferase 1 (cHS2ST) (EC 2.8.2.-) (Q76KB1)
Organism: Gallus gallus (Chicken)
Function: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8R3H7}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8R3H7}.
Interaction partners:
- Heparan-sulfate 6-O-sulfotransferase 1
- N-deacetylase and N-sulfotransferase 1.
- Exostosin-like 3
- Sulfotransferase
- Exostosin glycosyltransferase 1
- Glucuronic acid epimerase.
- Heparan-sulfate 6-O-sulfotransferase 2
- Heparan-sulfate 6-O-sulfotransferase
- Uncharacterized protein
- [heparan sulfate]-glucosamine N-sulfotransferase
Sequence:
MGLLRIMLPPKLQLLAVLVFGVAVLFLENQIQKLEESRGKLERAIARHEVREIEQRHTADGPRQEVALDEEDDVVIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFVKNVTSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDECVAAGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWALEQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRTGKKSHLRKTTEKKLPTKETIAKLQQSEIWKMENEFYEFALEQFQFVRAHAVREKDGELYILAQNFFYEKIYPKSN
Protein: Transforming acidic coiled-coil containing protein 2 (H0Y911)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
SVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEIREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSAL
Protein: Peptidoglycan recognition protein 4 (Peptidoglycan recognition protein I-beta) (PGLYRPIbeta) (PGRP-I-beta) (Peptidoglycan recognition protein intermediate beta) (Q96LB8)
Organism: Homo sapiens (Human)
Function: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
Subcellular location: Secreted {ECO:0000269|PubMed:16354652}.
Interaction partners:
- Peptidoglycan recognition protein 3
- Late cornified envelope protein 3B
- Late cornified envelope protein 1A
- Late cornified envelope protein 3C
Sequence:
MLPWLLVFSALGIQAWGDSSWNKTQAKQVSEGLQYLFENISQLTEKGLPTDVSTTVSRKAWGAEAVGCSIQLTTPVNVLVIHHVPGLECHDQTVCSQRLRELQAHHVHNNSGCDVAYNFLVGDDGRVYEGVGWNIQGVHTQGYNNISLGFAFFGTKKGHSPSPAALSAMENLITYAVQKGHLSSSYVQPLLGKGENCLAPRQKTSLKKACPGVVPRSVWGARETHCPRMTLPAKYGIIIHTAGRTCNISDECRLLVRDIQSFYIDRLKSCDIGYNFLVGQDGAIYEGVGWNVQGSSTPGYDDIALGITFMGTFTGIPPNAAALEAAQDLIQCAMVKGYLTPNYLLVGHSDVARTLSPGQALYNIISTWPHFKH
Protein: LD17962p (Stonewall, isoform A) (Stonewall, isoform C) (Q9VUE5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00371}.
Interaction partners:
Sequence:
MSAASEVNLMLLRSVEKQTALYDRTDENYRKRLPSENAWDMVASEVGESVEKCKRRWRQLRNDYTRWCNADANRRRNGQRRLAYPLADELRFLDRHLNIADDMAADDDRSVSSDKDRDNNRDSEGVDHHAQASLKERASSTSKLVKEVKLASQVRKEKSSQDKRENWENPGDKQRSRKKSAEEKLNDLEESDEPEKVPELDSFLQSDNEDDECMDEEHLEDLEGFDFDLEQSNQEKELTPEKSLEKNNTDSTVSQPEFFVKQTRDPRLLIIGRKNSTSSFAESKASKSISGDPLETAMEDSGDEYGRDGEKRVTGSDTTSPTRRPRRAARASISFAGIRDLPIQKPGQAQRMTRLQRRKSMSLAAVHSVRSSTSPVKMTPVPRSQPINKPPSGPVQITKISHRDDIFPRPAVPSGVVNINQNQLKTQQQQKTLIFPTTDEAIANPQGSGPPQRRSVGRPPKKLPMVQRIVAPETQTKPQSPINTKVLTIGKPTSSVASGNINNIAIKSNVVTSISSSTATTNTITKGTSNNSIKTTENVNVISYSPNSSSTSSSSKATTGASGAVITNIPTTTTAGTSVPVGKSITQLKMTERGTQTGVQNPFSDNYFLEMIKPQMQEMNPRQKMHFKKKVFQALMETFDDATDFPTSKELQHFNINTPSGFEHITDPELRLVRELVSMVSAAKVTLIRPPGEATAIATASRSGIAPEVQRGPRTNMTRQVIQRVYKPGTGQEIAPTSPAGGLDKRLFRLAAMGGKPNGNLSATQEILRKDSVDSNHSVVKVANHAPTGSPKGAAVVAAIRPQGSLINSFFGQGNGPTTAKGAASENIRAMSRRYSVCGSSNPPNAQNASQGSANGSTINSNASAMEASMLKRRLIAAGHGMVPPTQRPRYSAVGASQMTTASQGSSLLVRKSVGCVPAYQKQISPTGGASLLQKTPQIASVQGSAFNDFAQPKPAATASVNGEESSPTSALKRSLVVANTKTSFQDLLQQASQTVQRNKIESSETAATIAADDFSLDNLKREPVDPAEDHNDILGV
Protein: Cobalamin adenosyltransferase (ATR) (EC 2.5.1.-) (Q1LJ80)
Organism: Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
Function: Adenosyltransferase that catalyzes the conversion of cob(II)alamin to adenosylcob(III)alamin (AdoCbl) in the presence of ATP and an electron donor. Acts as an accessory protein of IcmF that functions in cofactor repair, since IcmF is prone to inactivation during catalytic turnover due to the occasional loss of the 5'-deoxyadenosine moiety and formation of the inactive cob(II)alamin cofactor in its active site. Thus, receives and repairs the inactive cofactor, which is then reloaded onto IcmF in a GTPase-gated step.
Interaction partners:
- Corrinoid adenosyltransferase
- Adenosylcobinamide-GDP ribazoletransferase
- Bifunctional adenosylcobalamin biosynthesis protein
- Cobyric acid synthase
- threonine-phosphate decarboxylase
- Cobalamin biosynthesis protein CobD
- Cobalamin biosynthesis protein CobD
Sequence:
MGNRLSKIATRTGDAGTTGLGDGSRVGKNSLRIVAIGDVDELNSHIGLLLTEPDLPEDVRAALLHIQHDLFDLGGELSIPGYTLLKAPQVAQLDDWLAHYNAALPRLAEFILPGGSRPAAQAHICRTVCRRAERALVELGAAEALNEAPRQYLNRLSDLLFVLARVLNRAGGGSDVLWQRERES
Protein: Cell adhesion molecule CEACAM3 (Carcinoembryonic antigen CGM1) (Carcinoembryonic antigen-related cell adhesion molecule 3) (CEA cell adhesion molecule 3) (CD antigen CD66d) (P40198)
Organism: Homo sapiens (Human)
Function: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MGPPSASPHRECIPWQGLLLTASLLNFWNPPTTAKLTIESMPLSVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNSLIVGYVIGTQQATPGAAYSGRETIYTNASLLIQNVTQNDIGFYTLQVIKSDLVNEEATGQFHVYQENAPGLPVGAVAGIVTGVLVGVALVAALVCFLLLAKTGRTSIQRDLKEQQPQALAPGRGPSHSSAFSMSPLSTAQAPLPNPRTAASIYEELLKHDTNIYCRMDHKAEVAS
Protein: Protein FAM98A (Q8NCA5)
Organism: Homo sapiens (Human)
Function: Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).
Interaction partners:
- ATP-dependent RNA helicase DDX1
- RNA transcription, translation and transport factor protein
- FMR1-interacting protein NUFIP2
- RNA-splicing ligase RtcB homolog
- Ataxin-2
- Ras GTPase-activating protein-binding protein 1
- Ataxin-2-like protein
- Ashwin
Sequence:
MECDLMETDILESLEDLGYKGPLLEDGALSQAVSAGASSPEFTKLCAWLVSELRVLCKLEENVQATNSPSEAEEFQLEVSGLLGEMNCPYLSLTSGDVTKRLLIQKNCLLLLTYLISELEAARMLCVNAPPKKAQEGGGSEVFQELKGICIALGMSKPPANITMFQFFSGIEKKLKETLAKVPPNHVGKPLLKKPMGPAHWEKIEAINQAIANEYEVRRKLLIKRLDVTVQSFGWSDRAKSQTEKLAKVYQPKRSVLSPKTTISVAHLLAARQDLSKILRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQDGPQQQTGGRGGGRGGYEHSSYGGRGGHEQGGGRGGRGGYDHGGRGGGRGNKHQGGWTDGGSGGGGGYQDGGYRDSGFQPGGYHGGHSSGGYQGGGYGGFQTSSSYTGSGYQGGGYQQDNRYQDGGHHGDRGGGRGGRGGRGGRGGRAGQGGGWGGRGSQNYHQGGQFEQHFQHGGYQYNHSGFGQGRHYTS
Protein: Forkhead box protein E1 (Forkhead box protein E2) (Forkhead-related protein FKHL15) (HFKH4) (HNF-3/fork head-like protein 5) (HFKL5) (Thyroid transcription factor 2) (TTF-2) (O00358)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:21177256}.
Interaction partners:
- Homeobox protein Nkx-2.1
- Paired box protein Pax-8
- Thyrotropin receptor
- Thyroglobulin
- Sodium/iodide cotransporter
- Thyroid peroxidase
- tRNA
- Pendrin
- Iodotyrosine deiodinase 1
Sequence:
MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM
Protein: Probable zinc transporter cis4 (Q9HGQ3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable zinc transporter involved in Golgi membrane trafficking through the regulation of zinc homeostasis.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein.
Interaction partners:
- Probable zinc transporter zrg17
- Uncharacterized serine-rich protein C1E8.05
- AP-1 complex subunit mu-1
- Zinc-regulated transporter 1
Sequence:
MNVNSSAFERTNRFPSFPVLKDDQKTSSDSIAAAKKKDLLSLISSKSLLSSETLGWFSVICAFSITGSGLEVNTMSIPFYLIFGIFAFVSFTTQYLGIYSFSFQPFQLLNVIIASLSMVFITLGAFVLGTLDTTCLLLLAFKLFFIRNDPTPFNARSANLKNYIAFPICLFVINHILILLGYFQCSYSVFYASVFYILLGVFIRVFYLVNKEKFEKKELAFLFSSIVVACLIQFNVLPLGTINLSVTRFTILCFMQIFCINWDGIARIQFYLGKFDISLIMALISAIINKTASQNSIKIISCLYQVGFCFFKIGSSITANLKLPDNSRIYRLYNDFIVNGVLADKESRSIFYFFLLNVSYMFVQVIYGLWTNSLGLISDAIHMAFDCIAILVGLVATTLAKMPLNYAYPFGFAKIEALSGFTNGIFLVLISFSIVGEALYRLFHPPQMNTDQLLLVSFLGLVVNLVGILAFNHGHNHDHGSHHHHSHSNHSMCLPNTTNDINIFEEFEEEKDNVEAQKMGYTNDDHVSQHEHTHENSQEHHHEHNHNHDHIHKYNEKCDHESISLQNLDNDHHCHHHHENHNMHGIFLHIIADTMGSVGVIVSTILIQWFSWTGFDPLASLIIAALIFVSVLPLIKDSAKNLLSVTDPESEYLLKQCLSNISLSNSVISLSNPKFWTNERGEVYGILHIQVSIDGDLNVVRNEVFRKLSIAVPNLKHICIQSERPNNCWCGK
Protein: RH23112p (Q8IGH1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
DSLSTSEAVGIVSTDEMEKIEAERQWLRYTVLPSILRNGRLVDNYSESKVTTFHVGDIDIDVIGHSEAFMLTFCYRTTINFEYDGQKFQRKMVVKKTPAMPPEMYESIQFGPLFTNEINFYTEILPEFQKFTDGKFAAPKYYYGELNQHSAVAILENFAEQGWRVTKDRVGLSLQHAMIAVSYLGRFHGFAYAMKHKNPEKFAQLTDNLKESRYANDNIHPEWKLTMKTSIDRAAKAVATYQPQIDEEFVKKFCFMISDYSQYGRQRVAPREPLATLCHGDYVRNNVAYRYDDKEEPQEIMMFDYQTLRVSSPMVDLNVFLAVSIFAEVRDPNFEAIFCEYTLALHNSYREHAKEEVPDFLSRGELLKEYVRFLPYSLSISASFLMSLVDPLDISPEEMFALQLSDEEIIERTMNRGGEVVDREVAHQVKEMLELSQATGVSIDDGIDLDKLPKE
Protein: A-kinase anchor protein 200 (Q9VLL3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Scaffolding protein involved in the regulation of PKA signaling and anchoring to the actin cytoskeleton integrating signals propagated by cAMP, diacylglycerol and calcium. Contributes to the maintenance and regulation of cytoskeletal structures in germline via PKA-mediated signaling. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology by anchoring PKA to the membrane of perineurial glia. In specific tissues such as eye and thorax, promotes N/Notch protein stability by inhibiting Cbl-mediated ubiquitination and lysosomal degradation pathway of N/Notch in a PKA-independent way. In the circadian brain neurons evening cells (E-cells), might have a role in circadian pacemaker synchronization by playing a redundant role in signaling downstream of the G protein-couple receptor Pdfr.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10480936, ECO:0000269|PubMed:10480937, ECO:0000269|PubMed:12223401}. Cell membrane {ECO:0000269|PubMed:10480937, ECO:0000269|PubMed:12223401}; Lipid-anchor {ECO:0000269|PubMed:10480937, ECO:0000269|PubMed:12223401}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:10480937}.
Interaction partners:
Sequence:
MGKAQSKRSIDITTDPKKVGEGDEVAGKVEKIDVDQKTDAPAVNGDAATPKEGGDEAAAVEKKETEEHSENDKDLTTEKSAAVAEGGDAVAETAKGEEGSPKEAAAGEDITPLADESIKSKSKKDKVKKKWSFRSISFGKKDKQKPAKSEEATSPTSGTTSPTTAEAEAAPAGDAAVAEPSVATNGEAEKPAETATATSEPASKDEKPAENGSATEQEKQANGETEKAAPAPSTVEEAAKPKPAEEPATVTATESNTTATEEVPVKESQPEPEVVTNGHGAGEALTNGSSNGLAESPVTETAPVADNIPSNVDDEPPHQNGTNGTTTPPPTPVATEIEKGQQIEASSEVIETVTPSQAEEEVVAAIIKAVSSEPEAETETETEAEGFVLVAPVSTEVEVPVSISPIEPVAEVSQVKIEPLVEIPEVEAKSVADVSEADTESVPKVSELKTEVSEIEFESVIVETRSSSPPPPLPKSPPPSRVSAFVLSEDVIEEQVTPNVPEVNDVKPDEIEQQAISIVAEITEQAAEIVTEQEKQQEEAKVDSVPETIEESSSTVVVEEVLPVQNDEVTAPSPTPDDVQKPIEDQDTPDEKESYPVPDPIDPAAVNDEVAVTEAVDCEVEKETGSISSNVAESSSVSDEQAAIENQVEILEEQTVAVEETTEQETSDQQVISEEAHSDNDKENEIDLVENIISDLDAPITKAGGDLLVELDARSAEQEGESNNKVDLAKDLKEKNAAAADVTTQEQLPVTCE