wanglab/gogpt-training-data huggingface dataset:
Protein: POU domain protein (A0A0R4J6S2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- M-phase-specific PLK1-interacting protein
- Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1a.
Sequence:
MITGQLSKPLLPLRADMDACELRDDDKAASPDSELNEEPLLLSADTDSEEKMYGGRVGSVQSDASSSPTEHGHMGQSHPTYPVGPQSLLVAQQLASAVSGVMSGGAPGLNQPILIPFNAGGHLGGQQGLVLSLPTAANIQGLVAAAAAGGIMALPLQNLQATSSLNSQLQHLQQLQQLQHHQQQQHHHHQQQQQQQQREREREREREREQREREQRERDQQREREQHQQLCGQAHLQPPSHHQLTPPIQSQVSGPSPGPVPTCPPSNHSSAQPPQSPPSHRQNQSPARSLPSPVTPPLPLQLNPLASQAAVAAAAAMGSIAGSQVFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNSVGPSNQSGGGTSPLQVQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLPQTGQTPQAPPVSQPNLLRMPHSQSPLRQASSSSSTSSSSSSALSVGQLVSNPQTAPSEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTGKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHRSGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNSHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQPEGLVPGAPMDPLVDNMEEHQ
Protein: Inner membrane protein (Q7CPD6)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Interaction partners:
- Uncharacterized protein YigF
- Invasol SirA
- Colanic acid polymerase
- Protein RarD
Sequence:
MPPLVRGVAYCHANDVTQHMDVKLMLSVFIPSSERCVSRCRYLLSFALINIIFSILVGVLLYLSFVILAILFTILLHYLVINLNCQRFRDSGFEYIKFYVWGTLVIYIASFVIMVAEDFACDGFGMPLFLIWYFATFSLLLLAPPDSNSLNK
Protein: Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3) (Q13352)
Organism: Homo sapiens (Human)
Function: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Subcellular location: [Isoform 1]: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
Interaction partners:
- Centromere protein Q
- Centromere protein P
- Centromere protein O
- Centromere protein U
- Centromere protein I
- Centromere protein L
- Centromere protein K
- Centromere protein T
- Centromere protein N
- Centromere protein H
Sequence:
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELENLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN
Protein: Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase) (Q99NI4)
Organism: Rattus norvegicus (Rat)
Function: Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate. Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:15528195, ECO:0000269|PubMed:16123124}.
Interaction partners:
- Inositol-pentakisphosphate 2-kinase
- Inositol-trisphosphate 3-kinase C
- Inositol-trisphosphate 3-kinase B
- Inositol-trisphosphate 3-kinase A
- Multiple inositol polyphosphate phosphatase 1
- Inositol polyphosphate 5-phosphatase K
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Sequence:
MAAEPPALRLRPPGSTGDSPPVPRLLGGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYTMVYAADCADAVLLELRKHLPKYYGVWSPPSAPNDVYLKLEDVTHKFNKPCIMDVKIGRKSYDPFASAEKIQQQVSKYPLMEEIGFLVLGMRVYHLHSDSYETQNQHYGRGLTKETLKEGVSKFFHNGFCLRKDAVAASIQKVEKILQWFENQKQLNFYASSLLFVYEGSSQPATTKSNDRTLAGRFLSKGALSDADVLECNNNFHLFSSPANGTSVGKSLSKAYSRHRKLYAKKHQSQTSLKVETLEQDNGWKSMSQEHLNGNVLSQLEKVFYHLPAGRQEIAEAEVRMIDFAHVFPSNTVDEGYVYGLKHLIAVLRSILDS
Protein: Transcription factor SRM1 (Myb-related protein SRM1) (Protein SALT-RELATED MYB 1) (Q9FNN6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that coordinates abscisic acid (ABA) biosynthesis and signaling-related genes via binding to the specific promoter motif 5'-(A/T)AACCAT-3'. Represses ABA-mediated salt (e.g. NaCl and KCl) stress tolerance. Regulates leaf shape and promotes vegetative growth.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:26243618}.
Interaction partners:
- Transcription factor MYB1
- F28N24.3 protein)
- Transcription factor UNE12
Sequence:
MTVEEVSDGSVWSREDDIAFERALANNTDESEERWEKIAADVPGKSVEQIKEHYELLVEDVTRIESGCVPLPAYGSPEGSNGHAGDEGASSKKGGNSHAGESNQAGKSKSDQERRKGIAWTEDEHRLFLLGLDKYGKGDWRSISRNFVVTRTPTQVASHAQKYFIRLNSMNKDRRRSSIHDITSVGNADVSTPQGPITGQNNSNNNNNNNNNNSSPAVAGGGNKSAKQAVSQAPPGPPMYGTPAIGQPAVGTPVNLPAPPHMAYGVHAAPVPGSVVPGAAMNIGQMPYTMPRTPTAHR
Protein: calcium/calmodulin-dependent protein kinase (EC 2.7.11.17) (F1RGR1)
Organism: Sus scrofa (Pig)
Interaction partners:
- Calmodulin like 5
- Uncharacterized protein.
- Calmodulin 3
- Calcium/calmodulin dependent protein kinase IV
- calcium/calmodulin-dependent protein kinase
- Family with sequence similarity 171 member A1.
- Uncharacterized protein.
- Adhesion G protein-coupled receptor A3
Sequence:
MEGGPAVCCQDPRAELVERVAAIDVAHLEETDDSPEPTRNCVDPPPRARAASMIPGGASRHLAARPSLSARKFSLQERPAGSCLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHYQKIIHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDARLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILALHRKIKNEAVVFPEERTGYLCTCAGTLSCTRALGVSPLLSDKPKVSEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEKEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLVSKDGCGEGGKSPELPGVQEDEAAS
Protein: phosphoinositide 5-phosphatase (EC 3.1.3.36) (Q5U0V7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Endophilin-A
- Dynamin associated protein 160, isoform D
- Dynamin
- Amphiphysin
- Phosphatidylinositol 4-kinase alpha
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 4-kinase type 2
- Phosphatidylinositol 4-kinase beta
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase
Sequence:
MAMSKVIRVLEKSIAPSPHSVLLEHRNKSDSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLGALQLNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLNSGTFYFAHTNASASASGASSYRFDITLCAQRRQQTQETDNRFFWNRMMHIHLMRFGIDCQSWLLQAMCGSVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTRGSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAMLSNEFQRHHGMSAHKDVPHVVFDYHQECRGGNFSALAKLKERIVACGANYGVFHASNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSKIYAGTGAIQGGSKLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNMLHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRKALAEGDFAASAWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLGPPDSTIVVHVLESSATGDEDGPTIYDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDGESALNASSKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLCANPVEHAQLLQAITPELPQRPKQPPTRPPARPPMPMSPKNSPRHLPHVGVISIVPKPAKPPMPPQPQSQPLIPSPLQPQVAPPRPPAMDTTPSSKSQSPTELVSASSSTSSSGKTSPTAPAVLSGPPTPPRQMQSKQATPVSTPTRQVGSPKDPIPSDTAYETASNIYEEIQEDVPAPRHPPPAGPPPVIGAPMGPPPPLPNRRGPPPIPNRSGNAPPLPTRPANN
Protein: Histone acetyltransferase (Q8I9K7)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MASLAAKKDGGDINGGPSEEEDQLQQLLGTSCCVNLSDSTVKRGFLLEVRYLWLPRLLSGNGTTGVAPQLYGFVRIKDADHRISGWFPIDCIDLKETGGANGATSCGSSYPTNSAAYNSMVVAKSKITHPIISPVYREVTPGMVRTRREGKQLDFFEERLLRDCRTPTTVRYFIYLCKFAFPPWYYAPYGMLNREYDPLAPLSDAEREALRFTEGSTNESIDTNPFIRDAYLCPFSLRIYSTFEQMQHETLRYRAGHLHPPGLEIYRDDTRGFSMFEVNGSRHVTYCRHLFLLGKSFLENKLAGHDVHNYYFYVVCLHHRHYPHYTDDTSAMYFVGYFTWEKQVTDNNLACIVTLPYFMGGGASSGQQKDLSDDRGPVGADTASREGDTPKLGHFGQFMIAASYELAYRRKNVGSPEKPLTDLGAAAYDRYWKRVLIKWMHTLLEGNAAAITVDDDAGDDGQSVTIVVAHENEAKMAAPGALKRPRPGTTDGSGCAEAVRGARVAEGDTLVDTTVRSIAKQVRLEEADVLRTLLQMGVLHLNAEDRSMRVVIPVSFVNREYGKMKKWAHDMTRAEFDPKLLTGRGGPAWLVNTPSPRRHNQHQS
Protein: Myb family transcription factor PHL4 (Protein PHR1-LIKE 4) (Q8GXC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor involved in male gametophyte development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
Interaction partners:
- SPX domain-containing protein 2
- SPX domain-containing protein 1
- At2g13960
- Transcription factor bHLH110
Sequence:
MIPNDDDDANSMKNYPLNDDDANSMKNYPLNDDDANSMENYPLRSIPTELSHTCSLIPPSLPNPSEAAADMSFNSELNQIMARPCDMLPANGGAVGHNPFLEPGFNCPETTDWIPSPLPHIYFPSGSPNLIMEDGVIDEIHKQSDLPLWYDDLITTDEDPLMSSILGDLLLDTNFNSASKVQQPSMQSQIQQPQAVLQQPSSCVELRPLDRTVSSNSNNNSNSNNAAAAAKGRMRWTPELHEVFVDAVNQLGGSNEATPKGVLKHMKVEGLTIFHVKSHLQKYRTAKYIPVPSEGSPEARLTPLEQITSDDTKRGIDITETLRIQMEHQKKLHEQLESLRTMQLRIEEQGKALLMMIEKQNMGFGGPEQGEKTSAKTPENGSEESESPRPKRPRNEE
Protein: F-box protein At2g40925 (Q3E7D1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MQRERSMKRKRRRRGIKDMCNRHDCEIPPDLMIEILIRLPTKSFMRFKCVSKQWSPLISGRYFCNRLFTCVTRQQQQQPRLYMCLVAKDKQCVLLSSTSPDNTCFVLVDQDLSIPGYFFASVPGLLCFQFGTKACIYNPSTKQLLTLPSVKSDITAQQGQLKTTQYYIGRDPVNDQYKLVCTILIYSKLFANMSSEHWVFTLELGGSWKKVVPLGNYHPHAPATAGRSIDGVVHYLAWVDLYKCAVVSFNIRSEEVTTFLLPRKIWDVPVPALMMKADLIEYDGKLAIFSHSYLKDEGLVELWVLKDAAGKKKWSNMILVLQPCQRHLVHGIDLIVKGTTQDGKVILSPLEMRSQFYILCYDVQNNDLRKVEITGVPRLWLHKECNFDLKFMDESESFIYLEI
Protein: Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) (Dolichol-phosphate mannose synthase) (DPM synthase) (Dolichyl-phosphate beta-D-mannosyltransferase) (Mannose-P-dolichol synthase) (MPD synthase) (O14466)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.
Subcellular location: Endoplasmic reticulum.
Interaction partners:
- Dolichol-phosphate mannosyltransferase subunit 3
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- Dol-P-Man:Man
- Dolichyl-phosphate beta-glucosyltransferase
- Mannose-1-phosphate guanyltransferase
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- Dolichol kinase sec59
- GPI mannosyltransferase 3
- Probable mannose-1-phosphate guanyltransferase
Sequence:
MSKYSVLLPTYNERKNLPIITYLIAKTFDQEKLDWEIVIIDDASPDGTQEVAKELQKIYGEDKILLKPRSGKLGLGTAYIHGLKFATGDFVIIMDADFSHHPKYLPEFIKLQKEHNYDIVLGTRYAKDGGVYGWNLKRKFISRGANLLASTVLGTGVSDVTGSFRLYKKPVLETLMSEVTSKGYVFQMEIIARAREHNYTIGEVPIAFVDRLYGESKLGMDDILGYLKGVFSLLFI
Protein: Catabolite control protein A (H7C6V6)
Organism: Enterococcus faecalis (strain ATCC 700802 / V583)
Interaction partners:
- Global transcriptional regulator CodY
- Sugar-binding transcriptional regulator, GntR family
- HPr kinase/phosphorylase
Sequence:
MEKQTITIYDVAREANVSMATVSRVVNGNPNVKPATRKKVLEVIDRLDYRPNAVARGLASKKTTTVGVIIPDVSNAFFASLARGIDDVATMYKYNIILANSDGDDQKEVTVLNNLLAKQVDGIIFMGHRITDDIRGEFSRSKTPVVLAGSIDPDEQVGSVNIDYTEATKDATATLAKNGNKKIAFVSGALIDPINGQNRMKGYKEALAENGLSYNEGLVFESEYKFKAGINLAERVRNSGATAAFVTDDELAIGLLDGMLDAGVKVPEEFEIITSNNSLLTEVSRPRLSSITQPLYDIGAVSMRLLTKLMNKEEIEEKTVVLPYGIDQKGSTK
Protein: Solute carrier family 41 member (D6R9S7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369007}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369007}.
Interaction partners:
Sequence:
MDGTETRQRRLDSCGKPGELGLPHPLSTGGLPVASEDGALRAPESQSVTPKPLETEPSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQHWPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQIDDPQEQHRVISSNLALIQV
Protein: NADH-ubiquinone oxidoreductase chain 2 (EC 7.1.1.2) (NADH dehydrogenase subunit 2) (P03891)
Organism: Homo sapiens (Human)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P03892}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- Cytochrome c oxidase subunit 3
- NADH dehydrogenase 1 alpha subcomplex subunit 8
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL
Protein: ThiJ/PfpI domain-containing protein (Q2UC87)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- Tropomyosin
- EF-hand domain-containing protein
Sequence:
MAPKVLVVLTSQAQIPDRDHATGWYLPEFAHPWEVLHEKVELTIASPKGGEAPLDPSSVEAFKSDPVSSKFLKEQESLWKNTHKLADFLPRVSEFDAIFYVGGHGPMFDLHYDETSLSLIQAFAAAGKPVSAVCHGPTVFIKATTKSGQPLLANSTVTAFTNVEEDQAQLTALMPYLVEDELNKIPGCKFVKADQPWGEKVVVSKTSDGATLITGQNPASATGLFFFRRIPTDQCTSNTQTTLTAMIAPDLWDRGRISLTQCRAWSSNTGDTKDEETDKHPRTNILKTSHLGNRQGGSGTKLAKTLAAAKGVAALQNVCCFIASAHMKRYARDGADRLASEIYKGRQHNNELAGLTVAAQGSQDGYDRDLFPHWISQGDSCDTREVVLARDGEDVEKNDSCSPTSGTWYSPYDGKTWTDKSDLDIDHVVPLSNAWKSGASDWTTDQRQAFANDLENPQLLAVTNSVNREKSDDGPEDWKPPLTSYYCTYAKMWVKVKSVYNLTITQDEKSALVDMLDSC
Protein: Antitoxin VapB15 (P9WLM7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC15. Partially inhibits the RNase activity of VapC15.
Interaction partners:
- Ribonuclease VapC15
- Ribonuclease VapC11
- Antitoxin VapB30
- Antitoxin VapB2
- Ribonuclease VapC5
- Putative antitoxin VapB5
Sequence:
MYSGVVSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES
Protein: Stearoyl-CoA desaturase (EC 1.14.19.1) (Q8I0W9)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Steroid dehydrogenase, putative
- 3-oxo-5-alpha-steroid 4-dehydrogenase, putative
- very-long-chain
- NADH-cytochrome b5 reductase, putative
- Cytochrome b5, putative
Sequence:
MIEMILSYVYKSLAGVLHTLNKSYLDIKDIGVTYLTYFIFLISCYLLKNYFSFKFLNFIRIVKSSIVLIICLISLKYLDLNLTLSINFFYLYNILQLSNFLEVSTSQNKKSNNKSKNVEAKVINKYELRNENEEKNYELIGDTSKHLEKIAKKILNNKKKLEENECILKEKEIIDEIERKEKEEEEIMKMKNNLNAKKNKDKRKDKINLYGIYVFFLQTFYIYFFYFFWNYIQNLIIIKIFLTLQLVKCLISFVSNFWINNMNINLFKRMIHILDIVYMFSISLFFTNILYNISQNTHFLRNFAVYSIVFHVYYAYVLFVKYIYTYHKQFRSSLFSFILFFHVFGIIGMIKLYYHEYGKSLLIQCVIFYLINGFGITFGAHRLWSHRAFKAGHIVQVLFLILNSFANQGSVIVWAINHRLHHKYSDTKYDPHNIRYGFFYSHVGWLLYQKTKYVKEKEKEIYVDDLLQNPYLLLQHKLDPYFNFFFCFIIPGIYSYFMYNNFWDGFFILGALRWIITLHATWSINSASHSFGHRPYNIDIKPTNNIFTSIVALGEGCHNYHHVFPYCYAMNENFYILSINPTKYLINFFYYLGLVWDLKCAKNICKEVRLRETLKLEKRNKALSENIKNEIMKKEDTSYVIELMNSFKALCNDYLNISTFMYILYFLRDIVIMITIFLIHICYCYNKYGNGTMFSTISQKFNIENNKYISISLSFFFHIILYTLPMGTMFASLYALVYECKRELLFKKPLFNHFFGSIISSFILLPYTSEKNRKSVLTALNEDFVKILKGPIYFDIYSLIFTFFSVFYIMTYYIFGYFYFCTFFLGPYIVFNAWLLIYIYLLKNPPFLQMDINTKEVDIGVLNYVAFQSLLQWKKNNSIYQSKKRLYKMVFSFINFIHHHLCYTHVVEFINASIPSYRTKEIYKHFDKTLDQYNFLRNDKFMDVLKEFL
Protein: Dynein axonemal assembly factor 5 HEAT-repeat domain-containing protein (Q585B8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDLFPKHLNELSDVARPKRLQAYTKLLDLCSDGKLTEGKEFDLLRSCLRGFEDSAERCREYAIQIVSSILVRQPPSVLDWVLPAVVTRIGVSPVAEESEELRLLLLRLAVLCMETFPHEIGPRNYIDFLQVLLENCLRDAYPDLKKEACRACVRLCEIEPVQVKHVSLPLAKVVKNCLLHKHSVVRAEAARTLASLIQRGAVEILADGKDEPANRTTAYTLFVLANDHAEVVRSALVDLLSMSLLDIQERQDQHRRLLPHLLLLVTDHFPAVSEKALQVLENMGKQYLLDNEDNTIDITKRRVTMKDIEWYGDEEYPDMSLTTVDTSLYPVLRRRPSLGARYVVAESLRGFIETVFADVCAIDWVVPFSSNNRRVVALRILWMSIYHTEKSVVQFVEQILGVLYKSLRDSQDVVQESLICLEILGKFLTPDQYLPFLTSKEAPKESEASQPTVIQSRSKTVVISSANGEATNSPTLFSTAAASVKCSILVAFRYLIEGSKSLLSATNATHIVSAMTKSDVLESDSEALLCSLLDTLDVVIKVLGERDFVATPDNPLPQEVRDDVNQRTLDSVLLYAFLCLRSSSFPSVQERVSKCTAHLSTVVTGQPGAIYDLHFKRILSRYGTRMPVSAFSDLVLSSSNIGMYGEQLSNIFLLKLSDIDFTQRVTDCLQYMRMLEELLWRKVPVFSGRQLEEVLRVVILPLGAFRPGGQAHLFRKVAVSSQCALLQEWHRKLLEPSLCDNAFALSSKVVTNWCNASDADDPEMRLMCMVNVPNLSYLPINAGSASDILQSIILRFDDSNDMIRAKAASGLLAILENKNEVCPIVIDEILSQATPLLKKLLIHLDDHDETVGLKPILVGVLKETAILAPSVTKDLVMDAMAKHQVPDYCQEVLLFIESL
Protein: Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (Serine-palmitoyl-CoA transferase 1) (Q6NR46)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- serine C-palmitoyltransferase
- ORM1-like protein
- 3-dehydrosphinganine reductase
- Serine palmitoyltransferase small subunit B
- LD18904p
- Ceramide kinase, isoform A
- ceramide glucosyltransferase
- Neutral ceramidase
- sphingosine kinase
- Putative neutral sphingomyelinase
Sequence:
MVAIQLFNEIGSIFRNTPTFALVLETLLLITVIWLLLHRRGGGRRRQLTKEEEDRIIADYEPEPLVADTDPNHPLLHTRVVQSRVGKRIQVDGHDCLNLGSHNYLGFLEDQEILEEACKSLRKYGVGSCGPRGFYGTMDVHLDLEDRIAKFMGLEEAIVYSYGFSTVASAIPAYAKRGDLIFVDEAVNFAIQKGLDASRSTIVFFKHNDVEDLERLLIEQEKRDQKNPKKAAKTRRFLVAEGIYMNTGEICPLPDLVALRQKYKLRLFIDESISFGTLGQGGHGVTEHFNVDRDEVDLISAGMEGSMATVGGFCVGSHFIAEHQRLSGLGYIFSASLPPMLTQAAISALDRFEREPQIFEQLQAKSKTLHQKFLRFSKLTLRGDEVSPVKHLYLAQPAENFDKELKLLTELADKCIARGVAVVQAAYLQNRERQPVRPSIRIAVNRLLESSEIDNAFEVIESVSSSVL
Protein: Chromosome 15 open reading frame 23, isoform CRA_d (Kinetochore localized astrin (SPAG5) binding protein) (V9GY01)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEELQALKVKLEMKEERVRFLEQQTLCNNQVNDLTTALKEMEQLLEM
Protein: Putative aquaporin 9 (Q4Q2F7)
Organism: Leishmania major
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLSEFLSQLVAEFVGTFLLVLTIALASVGVGALAPIPIGFMLAAMCFTFGYISGAHFNPAISFAVFINRKMTLRRTVMYIVVQLAGSFCASLYASAIIGLQIPAPVAKGDLANTWQVLLCELVYTFALTSVVLHVCFSRQRSNDFYGFAIGMTLMAAGFSVGGFTSGAFNPAVATGTQLVLCVYKNCDPLFYFWVYWIAPICGAFIASVIYQLLDTHESVPVVLGKEAVY
Protein: MTOR-associated protein MEAK7 (MEAK7) (MTOR associated protein, eak-7 homolog) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1) (Q6P9B6)
Organism: Homo sapiens (Human)
Function: Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration. Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome.
Subcellular location: Membrane {ECO:0000269|PubMed:24223779}. Cytoplasm {ECO:0000269|PubMed:24223779}. Lysosome {ECO:0000269|PubMed:29750193}.
Interaction partners:
- Ribonuclease kappa
- V-type proton ATPase catalytic subunit A
- V-type proton ATPase subunit e 1
- V-type proton ATPase subunit D
- V-type proton ATPase 16 kDa proteolipid subunit c
- V-type proton ATPase subunit H
- V-type proton ATPase subunit S1
- Renin receptor
- V-type proton ATPase subunit C 1
- V-type proton ATPase subunit G 1
Sequence:
MGNSRSRVGRSFCSQFLPEEQAEIDQLFDALSSDKNSPNVSSKSFSLKALQNHVGEALPPEMVTRLYDGMRRVDLTGKAKGPSENVSQEQFTASMSHLLKGNSEEKSLMIMKMISATEGPVKAREVQKFTEDLVGSVVHVLSHRQELRGWTGKEAPGPNPRVQVLAAQLLSDMKLQDGKRLLGPQWLDYDCDRAVIEDWVFRVPHVAIFLSVVICKGFLILCSSLDLTTLVPERQVDQGRGFESILDVLSVMYINAQLPREQRHRWCLLFSSELHGHSFSQLCGHITHRGPCVAVLEDHDKHVFGGFASCSWEVKPQFQGDNRCFLFSICPSMAVYTHTGYNDHYMYLNHGQQTIPNGLGMGGQHNYFGLWVDVDFGKGHSRAKPTCTTYNSPQLSAQENFQFDKMEVWAVGDPSEEQLAKGNKSILDADPEAQALLEISGHSRHSEGLREVPDDE
Protein: SNX26 protein (A1A5D2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFGHIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSESSAAGLGALSGSPSHRTSAWLDDGDELDFSPPPYPTPSWSLHSEGQTRSYC