wanglab/gogpt-training-data huggingface dataset:
Protein: LOB domain-containing protein 3 (ASYMMETRIC LEAVES 2-like protein 9) (AS2-like protein 9) (Q9SA51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000269|PubMed:17485849}.
Interaction partners:
- At1g30260/F12P21_9
- Protein BEARSKIN1
- Protein RESPONSE TO ABA AND SALT 1
- AT-hook motif nuclear-localized protein 11
Sequence:
MRQKGHRHGRTVSPCAGCKLLRRKCVKDSCVFAPYFPAKEPYKFAIVHKIFGASNVNKMLQELSENHRSDAVDSMVYEANARIQDPVYGCVGTISSLHRQLETLQTQLAFAQAELIHIRTLHRIHTKPPPYTASTVTFPSNKDFYSDIDMAVAYTDDAGDFLWSC
Protein: Histo-blood group ABO system transferase 1 (Blood group A glycosyltransferase 1) (Cis-AB transferase 1) (Fucosylglycoprotein 3-alpha-galactosyltransferase) (Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase) (Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase) (EC 2.4.1.40) (Glycoprotein-fucosylgalactoside alpha-galactosyltransferase) (EC 2.4.1.37) (Histo-blood group A transferase) (A transferase) (Histo-blood group B transferase) (B transferase) (N-acetylgalactosaminyltransferase A blood group-like enzyme) (NAGAT 1) (Q9ET32)
Organism: Rattus norvegicus (Rat)
Function: Posseses strong A transferase activity and a weak B transferase activity.
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). {ECO:0000250}.
Interaction partners:
- Galactoside alpha-
- Galactoside alpha-
- Alpha-
- Histo-blood group ABO system transferase 2
- Histo-blood group ABO system transferase 2
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
- L-Fucosyltransferase
Sequence:
MDLRGRPKCYSLHLGILPFIVLVLVFFGYGFLSHKIQEFRNPGGETCMATRQTDVQKVVSVPRMAYPQPNVLTPIRNDVLVFTPWLAPIIWEGTFNIDILNEQFKLQNTTIGLTVFAIKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPSDVPQVPLGAGRKLVVLTVRNYTRWQDVSMHRMEMISHFSEQRFQHEVDYLVCGDVDMKFSDHVGVEILSALFGTLHPGFYRSRRESFTYERRPKSQAYIPRDEGDFYYAGGFFGGSVVEVHHLTKACHQAMVEDQANGIEAVWHDESHLNKYLLYHKPTKVLSPEYVWDQKLLGWPSIMKKLRYVAVPKNHQAIRN
Protein: Protein disulfide-isomerase (PDI) (dPDI) (EC 5.3.4.1) (P54399)
Organism: Drosophila melanogaster (Fruit fly)
Function: Participates in the folding of proteins containing disulfide bonds.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Ero1-like protein
- Protein disulfide-isomerase A6 homolog
- Thioredoxin domain-containing protein 5 homolog
- Endoplasmic reticulum chaperone BiP
- Microsomal triacylglycerol transfer protein
- IP08350p
- Calreticulin
- Protein windbeutel
- Heat shock protein 83
- DSec61alpha
Sequence:
MKFLICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAKYEAKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYFRKEDNKVIDFNLDRTLDDFVKFLDANGEVADSEPVEETEEEEEAPKKDEL
Protein: DUF3013 domain-containing protein (A0A0H2URL1)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MATYGFLDILEEELDKNFPFDFEISWDKRNHAVEVSFLLEAQNAAGVEMVDEDGEVSSDDILFEEAVLFYNPAKSTVNEEDYLTVIPYLPKKGFSREFLAYFALFLKDTAEVGLDVLMDFLEDPEAEEFVMEWNQEVFEEGKIGLEKGEFYPYPRY
Protein: NADPH oxidase activator 1 (Q8CJ00)
Organism: Mus musculus (Mouse)
Function: Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16814099}. Cell membrane {ECO:0000269|PubMed:16814099}. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
Interaction partners:
- NADPH oxidase organizer 1
- Neutrophil cytosol factor 1
- Neutrophil cytosol factor 4
- Cytochrome b-245 light chain
- NADPH oxidase 1
- Neutrophil cytosol factor 2
- NADPH oxidase 2
- NADPH oxidase 3
- Ras-related C3 botulinum toxin substrate 1
- NADPH oxidase 4
Sequence:
MSSLGDQIRDWHRGVLAVAREDWDSALCFFSDVREPLARMYFNRGCVHLMAGDPEAALRAFDQAVTKDTCMAVGFLQRGVANFQLQRFQEAVSDFQLALAQLRDNAVIDYTQLGLNFKLQAWEVLYNMASAQCQAGLWTKAANTLVEAISKWPEGAQDILDIAMDKVQKQVPLQLQQVPKGEVFQPPRRYLKHLEPMDFLGKAKVVASVIPDDHNAQPQQRSQAEHAGHQPSSSMCKRVLSTTGGHTSPGLYDSLLASRRPGPGPSEVSSGSEGAATKDPESLVTVTVQCHFTVPLKVPRGTGLSSFQTLLAQALLHQTQTGQLSYKAPGEERSWIPISTEESLQSIWRNVPVGPGGLQLQCQGVWGRPVLYQVVAQYNYRAQRPEDLDFHQGDTVDVLCEVDEAWLEGHRDGCVGIFPKCFVVPAGAYVEAMLVLGPQPGDQN
Protein: Probable eukaryotic initiation factor 4A (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A) (Q580H2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Probable eukaryotic initiation factor 4A
- ATP-dependent DEAD/H RNA helicase, putative
- Poly
- Pescadillo homolog
- TOG domain-containing protein
- polynucleotide adenylyltransferase
Sequence:
MYGMNRGGGGGYRNDRMGALGANLQDVKWDQVNVVAPQWNYYKPQERCSDEEVAQYMRDNHITIYGDSVPQPMLKFSDLVAPDTIHQAFIDLGYKSPTPIQSIAWPILLNSRDLVGVAKTGSGKTMGFMVPAALHIMAQPPIRVGEGPIALVLAPTRELAVQIEEETRKVLRRVPTITTACLYGGTPKGPQIRALRAGVHVCIATPGRLIDLLEIRAANLLRVTFLVLDEADRMLDMGFEVQIRKICQQIRKDRQTLMFSATWPQEIRNLAASFQRDFIRVHVGSEDLIANADVTQHVSVVEDYDKQRRLEEILQKVGKQRVLIFVKTKRTADSLHHSLQRLIGGSVMAIHGDKEQSQRDYVLDRFRRDERSVLVATDVAARGLDIKNLDVVINFDMPTNIEDYVHRIGRTGRAGQRGDAYTFVSGADPSKTVRDLIDILRRANQEIPPGLHSLAGRGGGGSGGGGFRGGRRGGYGGGGGGYGYGRSGAQYGSGPTYGRDYRGAPSHHQSGISVGGNTSDAYWRGGAPPPGQQPYYPVCGGNKRTREVSGGFHSDPQNSYRQQPTGGSY
Protein: Brassinosteroid LRR receptor kinase BRI1 (EC 2.7.11.1) (Protein BRASSINOSTEROID INSENSITIVE 1 homolog) (OsBRI1) (Protein DWARF 61) (Q942F3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Receptor kinase involved brassinosteroid (BR) signal transduction. Regulates, in response to BR binding, a signaling cascade involved in plant development, promotion of cell elongation and flowering (Probable). Activates BR signaling by targeting and phosphorylating BSK3, a positive regulator of BR signaling. Forms at the plasma membrane a receptor complex with BAK1 which is activated in response to brassinolide. Phosphorylates BAK1. Phosphorylates REM4.1, which reduces REM4.1 binding affinity to BAK1 and allows the formation and subsequent activation of the BRI1-BAK1 receptor complex. Functions in various growth and developmental processes, such as internode elongation, bending of the lamina joint and skotomorphogenesis. Functions in internode elongation by inducing the formation of the intercalary meristem and the longitudinal elongation of internode cells. Involved in organ development through the control of cell division and elongation. Does not seem essential for organ pattern formation or organ initiation.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Probable BRI1 kinase inhibitor 1
- LRR receptor kinase BAK1
- Probable serine/threonine-protein kinase BSK3
- non-specific serine/threonine protein kinase
- Os08g0474500 protein
- Serine/threonine-protein kinase BSK1-2
- LRR receptor kinase SERK2
- Os07g0503400 protein
- non-specific serine/threonine protein kinase
- LRR receptor kinase SERK2
Sequence:
MDSLWAAIAALFVAAAVVVRGAAAADDAQLLEEFRQAVPNQAALKGWSGGDGACRFPGAGCRNGRLTSLSLAGVPLNAEFRAVAATLLQLGSVEVLSLRGANVSGALSAAGGARCGSKLQALDLSGNAALRGSVADVAALASACGGLKTLNLSGDAVGAAKVGGGGGPGFAGLDSLDLSNNKITDDSDLRWMVDAGVGAVRWLDLALNRISGVPEFTNCSGLQYLDLSGNLIVGEVPGGALSDCRGLKVLNLSFNHLAGVFPPDIAGLTSLNALNLSNNNFSGELPGEAFAKLQQLTALSLSFNHFNGSIPDTVASLPELQQLDLSSNTFSGTIPSSLCQDPNSKLHLLYLQNNYLTGGIPDAVSNCTSLVSLDLSLNYINGSIPASLGDLGNLQDLILWQNELEGEIPASLSRIQGLEHLILDYNGLTGSIPPELAKCTKLNWISLASNRLSGPIPSWLGKLSYLAILKLSNNSFSGPIPPELGDCQSLVWLDLNSNQLNGSIPKELAKQSGKMNVGLIVGRPYVYLRNDELSSECRGKGSLLEFTSIRPDDLSRMPSKKLCNFTRMYVGSTEYTFNKNGSMIFLDLSYNQLDSAIPGELGDMFYLMIMNLGHNLLSGTIPSRLAEAKKLAVLDLSYNQLEGPIPNSFSALSLSEINLSNNQLNGTIPELGSLATFPKSQYENNTGLCGFPLPPCDHSSPRSSNDHQSHRRQASMASSIAMGLLFSLFCIIVIIIAIGSKRRRLKNEEASTSRDIYIDSRSHSATMNSDWRQNLSGTNLLSINLAAFEKPLQNLTLADLVEATNGFHIACQIGSGGFGDVYKAQLKDGKVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKAGEERLLVYDYMKFGSLEDVLHDRKKIGKKLNWEARRKIAVGAARGLAFLHHNCIPHIIHRDMKSSNVLIDEQLEARVSDFGMARLMSVVDTHLSVSTLAGTPGYVPPEYYQSFRCTTKGDVYSYGVVLLELLTGKPPTDSADFGEDNNLVGWVKQHTKLKITDVFDPELLKEDPSVELELLEHLKIACACLDDRPSRRPTMLKVMAMFKEIQAGSTVDSKTSSAAAGSIDEGGYGVLDMPLREAKEEKD
Protein: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) (Q16654)
Organism: Homo sapiens (Human)
Function: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- Stress-70 protein, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Non-selective voltage-gated ion channel VDAC1
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
- [Pyruvate dehydrogenase
- [Pyruvate dehydrogenase
- Pyruvate dehydrogenase protein X component, mitochondrial
Sequence:
MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
Protein: Syncytin-2 (ERV-FRD provirus ancestral Env polyprotein) (Envelope polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] (P61557)
Organism: Pan troglodytes (Chimpanzee)
Function: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (By similarity).
Subcellular location: Virion {ECO:0000305}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250|UniProtKB:Q9UQF0}.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sodium-dependent lysophosphatidylcholine symporter 1
- RNA helicase
Sequence:
MGLLLLVLILTPSLAAYRHPDFPLLEKAQQLLQSTGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKGLMRPANSLLSMVKQDFPDIRQKPPIFGPIFTNINLMGIAPICVMAKRKNGTNVGTLPSTVCNVTFTVDSNQQTYQTYTHNQFRHQPRFPKPPNITFPQGTLLDKSSRFCQGRPSSCSTRNFWFRPADYNQCLQISNLSSTAEWVLLDQTRNSLFWENKTKGANQSQTPCVQVLAGMTIATSYLGISAVSEFFGTSLTPLFHFHISTCLKTQGAFYICGQSIHQCLPSNWTGTCTIGYVTPDIFIAPGNLSLPIPIYGNSQLPRVRRAIHFIPLLAGLGILAGTGTGIAGITKASLTYSQLSKEIANNIDTMAKALTTMQEQIDSLAAVVLQNRRGLDMLTAAQGGICLALDEKCCFWVNQSGKVQDNIRQLLNQASSLRERATQGWLNWEGTWKWFSWVLPLTGPLVSLLLLLLFGPCLLNLITQFVSSRLQAIKLQTNLSAGRHPRNIQESPF
Protein: Lumican (F1SQ09)
Organism: Sus scrofa (Pig)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- Collagen type I alpha 2 chain
- Fibrillin-1
- SPARC
- Uncharacterized protein.
- Decorin
- Collagen alpha-1
- Transforming growth factor beta-2 proprotein
- Tumor necrosis factor ligand superfamily member 6
- E3 ubiquitin-protein ligase Mdm2
- Collagen type I alpha 1 chain
Sequence:
MHLGVFTLLLATIGSASGHYYDDDDYYFPLSIYGRSSPNCAPECNCPESYPTAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDDKAFENVTDLEWLILDHNLLENSKIKGRVFSKLKQLKKLHINYNNLTESVGPLPKSLVDLQLTNNKISKLGSFDGLVNLTFIHLQHNQLKEDAVSAAFRGLKGLEYLDLSFNQMTKLPSGLPVSLLTLYLDNNKISNIPDEYFKHFSGLQYLRLSHNELADSGIPGNSFNLSSLLELDLSYNKLKNIPTVNENLENYYLEVNELEKFEVKSFCKILGPLSYSKIKHLRLDGNRITQTSLPPDMYECLRVANEITVN
Protein: Probable E3 ubiquitin-protein ligase ARI14 (EC 2.3.2.31) (ARIADNE-like protein ARI14) (Protein ariadne homolog 14) (RING-type E3 ubiquitin transferase ARI14) (Q9FFP1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. Regulates negatively male gametophyte formation and double fertilization.
Interaction partners:
- Protein KOKOPELLI
- AAA-type ATPase family protein
- Kinesin-like protein KIN-10B
Sequence:
MEYDGRRPYSVLTRNEITVKMKKQINEISDIFFISNSDATVLLMYLRWDSLRVSERLGENKEKLLMDSGLKSVMIDPSPDSSSEISLETDVYEFDGDNDLISMPFCSHKFDSKYWREYLEKNFYYVEKIQTTISCPDQDCRSAVGPDTIEKLTVRDQEMYERYIWRSYIEGNKVLMIKQCPARNCDYVIEFHQENDDDDEYSLNVVCICGHIFCWRCRLESHRPVSCNKASDWLCSATMKISDESFSLYPTKTKTVTCPHCLCSLESDTKMPQFLTCVCRLRFCSRCLRSEEAHKIEAVDSGFCIKTEVGILCEDRWNVCQKLLEQAKSDLEAFEETNIKKPSDLLREQDIMIIREGLMLIVQCRRVLKWCCVYDYFHTEYENSKEYLRYLQGNAIATLQSYSNTLQEQKDIVLAAATYEECTFFRHTIPTATSNIGNYFYDFMKTLQDGLVDVKVKSYNGGTGPFWYCDRCTYANTWEDNECEMCYDDSASLVGEISDLFLNKVS
Protein: Probable oxidoreductase patJ (EC 1.-.-.-) (Patulin biosynthesis cluster protein J) (A0A075TR41)
Organism: Penicillium expansum (Blue mold rot fungus)
Function: Probable oxidoreductase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria. PatJ acts with patO in the vacuole to convert gentisyl alcohol to isoepoxydon. The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable).
Subcellular location: Vacuole lumen {ECO:0000269|PubMed:30680886}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:30680886}.
Interaction partners:
Sequence:
MAPFVPYHYSAGQSTIVKFGGLLTTEFLEPPPGRCFLFRQTYRHTIEGSIPENLRKLINSPDRPKGPPPHFHQFQTEYFRVENGVLGISVDGVVRRITPEDGEISVKAGSVHNFFIHPDSPENMTVYLSASDSGNDYQLDRVFFENWYGYWHDALLHDGGIDWIQFLAIQDGGDAYTPAPAWVPFRRQVGYWTCVIVGRWIGGLLGYKPFFREYTTDWDFAVAKMKGSFFQRHLVHAAFEEEKSWTKQAELEPKGKPENAEFEPWTEDMSPAPLSLGPVAYEQGLFHGVQPGSVNGSNGHSTGVESKLEQLGSRAQRRVVIDDAGK
Protein: ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) (Q8IUD2)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27224062}. Cytoplasm {ECO:0000250|UniProtKB:Q811U3}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q811U3}. Cell projection, podosome {ECO:0000250|UniProtKB:Q99MI1}. Note=Recruited on Golgi membranes by RAB6A in a GTP-dependent manner (By similarity). Localized to the cortex of myotube podosomes (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q99MI1}.
Interaction partners:
- NF-kappa-B essential modulator
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Protein unc-13 homolog B
- Liprin-alpha-1
- Pleckstrin homology-like domain family B member 2
- Ras-related protein Rab-6A
- Liprin-alpha-3
- Regulating synaptic membrane exocytosis protein 1
- E3 ubiquitin ligase TRIM40
Sequence:
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQVVNALEESS
Protein: 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) (2-keto-3-deoxygluconokinase) (3-deoxy-2-oxo-D-gluconate kinase) (KDG kinase) (Q53W83)
Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Function: Involved in the degradation of glucose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG).
Interaction partners:
Sequence:
MLEVVTAGEPLVALVPQEPGHLRGKRLLEVYVGGAEVNVAVALARLGVKVGFVGRVGEDELGAMVEERLRAEGVDLTHFRRAPGFTGLYLREYLPLGQGRVFYYRKGSAGSALAPGAFDPDYLEGVRFLHLSGITPALSPEARAFSLWAMEEAKRRGVRVSLDVNYRQTLWSPEEARGFLERALPGVDLLFLSEEEAELLFGRVEEALRALSAPEVVLKRGAKGAWAFVDGRRVEGSAFAVEAVDPVGAGDAFAAGYLAGAVWGLPVEERLRLANLLGASVAASRGDHEGAPYREDLEVLLKATQTFMR
Protein: Protein AMN1 homolog (B8JKV0)
Organism: Mus musculus (Mouse)
Interaction partners:
- Tripartite motif-containing protein 75
Sequence:
MPLSGVVSQLLELCLQYLVINISRYISDIKYLPSNIKDRLIKIMSIRGRITDSNISEVLHPEVQRLDLRSCDISDVALQHLCKCRKLKALNLKSCREHRNSITSEGIKAVASSCSDLHEIYLKGCCSVTDEGVLALALNCHLLKIIDLGGCLGITDVSLHALGKNCPFLQCVDISTTQVSDNGVVALVSGPCAKQLEEINMRYCINLTDKAVEAALTACPRICILLFHGCPLITDRSQEVLEQLIGSRKLKQVTWSVY
Protein: Lipase (Q9VPE9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Zinc carboxypeptidase A 1
- Uncharacterized protein, isoform A
- Niemann-Pick type C-2d
- Trypsin theta
- Jonah 25Biii
- trypsin
- RE65433p
- LP05863p
- Venom allergen-1
- GH20109p
Sequence:
MNPIFCALLFSLVAGLVLAEKSDYCLSEIVKSDERIRSHGYPTETHEVTTQDGYVLTLFRIPYSHKLKNQNEKRPPILLQHGLFSNSDCWLSSGPDNSLAYLLADAGYDVWLGNARGNIYSRNNIIISLNSHKFWHFDWHEIGTIDIPAMIDYILADTGFDQIHYAGHSQGTTVYLVMLSERPEYNALIKSGHLLAPCAFFEHGTSFIFNALGPLVGTPGGIWNQLLVDTELIPNNNLVNRLVDNSCHLSNTICNNAFIMFANGGYVNANASSMSVLIETHPAGSSSNQGIHYLQLWKSLKFRQYDWGTKKNNELYGQDLPPDYDLSKIVAPTHLYSSTNDALCGPEDVNTLVENFPHLTEDYRVPVQSFNHLDFIIAKNMKELVNDPIIERINSYEGR
Protein: Trypanosoma glutamic acid/alanine-rich protein domain-containing protein (Q57XH8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTRFTCFTAVVLLCMPFAVGKNNNLTLEQTVTLCNALKQFRGLKDAVRDLKYWITTESLKISNAKTRSDEQLRRVKEPAQATTKAKALEKRARVLAANVTEAVKKAEIVILESDVDAGVLGTISSAYVPSLEGALKKLGNEGGTVEVKGVAKSCNKTTKNVTVESLIHALDDMLQYFPAKSIKRLKEATRDASNKLHKLEGAAQSLVEIKINAEYTEFRVREAVTKAVSAYGKRYNLTLQQTQALCIAAEQYRALPIFVSNIEEISKTMAQKAADAKIRSDNVVQLAEEANEDGKGKLLSQRVRETVNEIAEAAEAAEKAYRALTGHSVYMKSVAAAYAGSLEKTLLSISQYAASQATRKAAEACRETAEVVTPKSLEDTKNGLFHSIPAQSSKRLKKDTAKLIESLTILHREYKQLNAAMQYAQAAELKLNRETDYSPTTTPIAFASFLVCLLGTGLL
Protein: FCS-Like Zinc finger 1 (Q9FGQ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:24901469}. Cytoplasm {ECO:0000269|PubMed:24901469}.
Interaction partners:
- FCS-Like Zinc finger 16
- FCS-Like Zinc finger 11
- FCS-Like Zinc finger 8
- Inositol diphosphatase DSP3
- Protein MARD1
- MADS-box family protein
- Dual specificity protein phosphatase PHS1
- LIM domain protein
Sequence:
MELSSRKPYFIEEEEEENLASSLSEMEAGFSGNNNNSNNHGNPQNGVVSSSRFSYGRLNSLRNSQSYYYNQYSVSSPRSVVSGRFHDFRFDIQQPHFLDSCFLCKKPLGDNRDIYMYRGDTPFCSEECRQEQIERDEAKEKKQNLSHSVKSAMRRKEQSSPTRSRDYAFHNGTVAAA
Protein: TEA domain transcription factor 4 (H0YG62)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XGKTRTRKQVSSHIQVLARRKAREIQAKLKTGAELGTCGREDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVD
Protein: PGA2-homolog C27.01c (Q9P6S6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved processing and trafficking glycosylated proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Single-pass membrane protein {ECO:0000269|PubMed:16823372}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Interaction partners:
- Chromatin structure-remodeling complex subunit sfh1
Sequence:
MGFDVAGYLQSYSLKDWIRIIVYVGGYMLIRPYLMKLGAKIQEREHRKSLLEGEVDGTLDPEMTHGTKPKEHGEFDTDDEEEEENPDAEFRWGYSARRRIRKQREEYFKNQDKSPLDAYADDDEDIEEHLED