wanglab/gogpt-training-data huggingface dataset:
Protein: histone acetyltransferase (EC 2.3.1.48) (F1RK46)
Organism: Sus scrofa (Pig)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Interferon regulatory factor 3
- Cyclic AMP-responsive element-binding protein 1 isoform B.
- Hypoxia-inducible factor 1-alpha
- histone acetyltransferase
- Cellular tumor antigen p53
- Catenin beta 1.
- RELA proto-oncogene, NF-kB subunit
- Nuclear receptor coactivator 1
- Signal transducer and activator of transcription 1
- Hypoxia-inducible factor 1-alpha
Sequence:
MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSSSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLGAMGKSPLNQGDSSAPNLPKQAASTSGPTPPASQALNPQAQKQVGLVTSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLMNQAQQGQAQVMNGSLGAAGRGRGAGMPYPAPAMQGATSSVLAETLTQVSPQMASHAGLNTAQTGGMTKMGMAGNTSPFGQPFSQAGGQQMGAPGVNPQIPGKQSMVNSLPPFPADIKNASVTSVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYLNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPSLISESALPTSLGATNPLMSDGATSGNIGPLSTLPSAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGTQPPGIPQAQPVRPPNGPMPLPVNRMQVSQGMNSFTPMSLGNVQLPQAPMGPRAASPMNHSVPMNSMGSVPGMAISPSRMPQPPNMMGTHANNMMAQAPAQNQFLPQNQFPSASGAMSVNSVGLGQPAAQAAVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHQTPPPASTAAGLPSLQHPVAPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSASQSQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHTQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKAEVKTEDTEPDASEPKGEPGSGMMEEDLQGSSQVKEETDTTEQKSEPMEVDEKKPEVKVEAKEEEDGGANGAASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRTRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHTHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSAGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNGMPPGRTGMVTPGSQMAPVGLNVPRPNQVSGPVVPNLPPGQWQQAPIPQQQPMPGMPRPVMSMPAQPAVAGPRMPSVQPPRSISPGALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVASQPGLQAQPSLQAQPGLQPQPGLHQQPGLQNLNAMQAGGPRPGVPPQQQTMGGLNPQGQALNIMNPGHSPSMASMNPQYREMLRRQLLQQQQQQQQQQQQQQGGAGMAGGMAGHGQFQQPQGPGGYPPAMQQQRMQQHLPIQGGSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQMATSLSSQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPNRSALSSELSLVGDTTGDTLEKFVEGL
Protein: RxLR effector candidate (G3C9P1)
Organism: Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent) (Peronospora arabidopsidis)
Interaction partners:
Sequence:
AATVAASTHGLEVVPDPVKFSLLQATAETGHQADVDGKINRFLTSKDADLPHLVAPAGYAPSLLQKGGIGRYLRSTGVDDADLEERRGWHKHHKKHKKHKRKHHHHAHESSDSL
Protein: Trafficking kinesin protein 1 (A0A8I5ZSR6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MALAIQLRQPSRAQPLPGLDHTLAGTNSCDVCNSTNLPEVEIISLLEEQLPHYKLRADTIYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEACQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKSCAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEPESPDITHQKRVFETVRNVNQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDVSHVVLDNKTNSILLETEAADLGNEEHNKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLRELAEKGELHSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLAGLATSTTIQHMETSAHHPGKCMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPAPSCSSTSHLKSTPVATPCTPRRLSLAESFTNVRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPRMAVIPSTPPNSPMQTPSASPPSFEFKCTSPPYNNFLASKPASSILREVREKKHVRSSESQTDVSVSNLNLVDKVRRFGVARVVNSGRAHIPTLTEDQGPLLCGPTGPAHALVPGGLVPEGLPLGCPSGIRRNRSFPTMVGSSVQMRAPVILTSGILMGAKLPKQTSLR
Protein: Leucine-rich repeat receptor-like protein kinase PXC2 (Protein PXY/TDR-CORRELATED 2) (Q9LZV7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Leucine-rich repeat receptor-like protein kinase that may play a role in vascular tissues development.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Peroxidase 13
- Protein IQ-DOMAIN 3
- IQ-domain 21
- Protein DETOXIFICATION 49
- Probable protein phosphatase 2C 64
- IQ-domain 24
- Peroxidase 31
Sequence:
MFNGAVSLLFLFLAVVSARADPTFNDDVLGLIVFKAGLDDPLSKLSSWNSEDYDPCNWVGCTCDPATNRVSELRLDAFSLSGHIGRGLLRLQFLHTLVLSNNNLTGTLNPEFPHLGSLQVVDFSGNNLSGRIPDGFFEQCGSLRSVSLANNKLTGSIPVSLSYCSTLTHLNLSSNQLSGRLPRDIWFLKSLKSLDFSHNFLQGDIPDGLGGLYDLRHINLSRNWFSGDVPSDIGRCSSLKSLDLSENYFSGNLPDSMKSLGSCSSIRLRGNSLIGEIPDWIGDIATLEILDLSANNFTGTVPFSLGNLEFLKDLNLSANMLAGELPQTLSNCSNLISIDVSKNSFTGDVLKWMFTGNSESSSLSRFSLHKRSGNDTIMPIVGFLQGLRVLDLSSNGFTGELPSNIWILTSLLQLNMSTNSLFGSIPTGIGGLKVAEILDLSSNLLNGTLPSEIGGAVSLKQLHLHRNRLSGQIPAKISNCSALNTINLSENELSGAIPGSIGSLSNLEYIDLSRNNLSGSLPKEIEKLSHLLTFNISHNNITGELPAGGFFNTIPLSAVTGNPSLCGSVVNRSCLSVHPKPIVLNPNSSNPTNGPALTGQIRKSVLSISALIAIGAAAVIAIGVVAVTLLNVHARSSVSRHDAAAALALSVGETFSCSPSKDQEFGKLVMFSGEVDVFDTTGADALLNKDSELGRGGFGVVYKTSLQDGRPVAVKKLTVSGLIKSQEEFEREMRKLGKLRHKNVVEIKGYYWTQSLQLLIHEFVSGGSLYRHLHGDESVCLTWRQRFSIILGIARGLAFLHSSNITHYNMKATNVLIDAAGEAKVSDFGLARLLASALDRCVLSGKVQSALGYTAPEFACRTVKITDRCDVYGFGILVLEVVTGKRPVEYAEDDVVVLCETVREGLEEGRVEECVDPRLRGNFPAEEAIPVIKLGLVCGSQVPSNRPEMEEVVKILELIQCPSHDLE
Protein: Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) (Q7L5D6)
Organism: Homo sapiens (Human)
Function: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:29042515, ECO:0000269|PubMed:32395830}.
Interaction partners:
- Large proline-rich protein BAG6
- Small glutamine-rich tetratricopeptide repeat-containing protein alpha
- Ubiquitin-like protein 4A
- ATPase GET3
- Guided entry of tail-anchored proteins factor 1
- E3 ubiquitin-protein ligase RNF126
- Small glutamine-rich tetratricopeptide repeat-containing protein beta
- Guided entry of tail-anchored proteins factor CAMLG
- E3 ubiquitin-protein ligase AMFR
- Protein transport protein Sec61 subunit beta
Sequence:
MAAAAAMAEQESARNGGRNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQSKHTEARELMYSGALLFFSHGQQNSAADLSMLVLESLEKAEVEVADELLENLAKVFSLMDPNSPERVTFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYCESRYHFLHSADGEGCANMLVEYSTSRGFRSEVDMFVAQAVLQFLCLKNKSSASVVFTTYTQKHPSIEDGPPFVEPLLNFIWFLLLAVDGGKLTVFTVLCEQYQPSLRRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLTSLMGSSEQEDGEESPSDGSPIELD
Protein: Pancreatic polypeptide prohormone (PH) (Pancreatic polypeptide Y) (Obinepitide) [Cleaved into: Pancreatic polypeptide (HPP) (PP); Pancreatic icosapeptide (PI)] (P01298)
Organism: Homo sapiens (Human)
Function: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
Subcellular location: Secreted {ECO:0000269|PubMed:7493937, ECO:0000269|PubMed:7592911, ECO:0000269|PubMed:828120}.
Interaction partners:
- Neuropeptide Y receptor type 4-2
- Neuropeptide Y receptor type 2
- Somatostatin
- Pro-glucagon
- Peptide YY
- Neuropeptide Y receptor type 1
- Neuropeptide Y receptor type 5
- Insulin
- Gastrin
- Pro-neuropeptide Y
Sequence:
MAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL
Protein: DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (RPB6 homolog) (O88828)
Organism: Rattus norvegicus (Rat)
Function: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P61218}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P61218}.
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase subunit beta
- RNA polymerase I and III subunit C.
- DNA-directed RNA polymerase I subunit RPA2
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerase subunit
Sequence:
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKYERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGVDELIISD
Protein: Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase R) (CPR) (Carboxypeptidase U) (CPU) (Thrombin-activable fibrinolysis inhibitor) (TAFI) (Q9JHH6)
Organism: Mus musculus (Mouse)
Function: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
Subcellular location: Secreted {ECO:0000269|PubMed:10739389}.
Interaction partners:
- Prothrombin
- Carboxypeptidase B
- Plasminogen
- Thrombomodulin
- Alpha-2-antiplasmin
- Vitamin K-dependent protein C
- Complement component C8 beta chain
- Complement C5
- Antithrombin-III
- Tissue-type plasminogen activator
Sequence:
MKLHGLGILVAIILYEQHGFAFQSGQVLSALPRTSRQVQLLQNLTTTYEVVLWQPVTAEFIEKKKEVHFFVNASDVDSVKAHLNVSRIPFNVLMNNVEDLIEQQTFNDTVSPRASASYYEQYHSLNEIYSWIEVITEQHPDMLQKIYIGSSFEKYPLYVLKVSGKEQRIKNAIWIDCGIHAREWISPAFCLWFIGYVTQFHGKENLYTRLLRHVDFYIMPVMNVDGYDYTWKKNRMWRKNRSAHKNNRCVGTDLNRNFASKHWCEKGASSSSCSETYCGLYPESEPEVKAVADFLRRNIDHIKAYISMHSYSQQILFPYSYNRSKSKDHEELSLVASEAVRAIESINKNTRYTHGSGSESLYLAPGGSDDWIYDLGIKYSFTIELRDTGRYGFLLPERYIKPTCAEALAAISKIVWHVIRNT
Protein: DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit 2) (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 130 kDa polypeptide) (RPC130) (Q10233)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerase III subunit rpc1
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase III subunit RPC10
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- Probable DNA-directed RNA polymerase III subunit rpc6
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerase III subunit rpc31
Sequence:
MGVNTAGDPQKSQPKINKGGIGKDESFGALFKPVYKGKKLADPVPTIEDKWQLLPAFLKVKGLVKQHLDSYNYFVDVDLKKIVQANEKVTSDVEPWFYLKYLDIRVGAPVRTDADAIQASISPHECRLRDLTYGANIYVDIEYTRGKQVVRRRNVPIGRMPVMLRSNKCVLSGKNEMEMAALNECPLDPGGYFIVKGTEKVILVQEQLSKNRIIVEAEPKKGLWQASVTSSTHERKSKTYVITKNGKLYLKHNSVADDIPIVVVLKAMGLQSDQEIFELVAGAEASYQDLFAPSIEECAKLNIYTAQQALEYIGARVKVNRRAGANRLPPHEEALEVLAAVVLAHINVFNLEFRPKAVYIGIMARRVLMAMVDPLQVDDRDYVGNKRLELAGQLLALLFEDLFKKFNSDLKLNIDKVLKKPHRTQEFDAYNQLTVHSDHITQGMVRALSTGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRITSQFEKTRKVSGPRSLQASQFGMLCTSDTPEGEACGLVKNLALMTHITTDEEEEPIIKLAYAFGIEDIHVISGRELHSHGTYLVYLNGAILGISRYPSLFVASFRKLRRSGKISPFIGIFINTHQRAVFISTDGGRICRPLIIVQNGLPKVESKHIRLLKEGKWGFEDFLKQGLVEYVDVNEENDSLISVYERDITPDTTHLEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQLQRIDTLLYLMVYPQQPMVKTKTIELIGYDKLPAGQNATVAIMSYSGYDIEDALVLNKSSIDRGFGRCQVFHKHSVIVRKYPNGTHDRIGDPQRDPETGEVVWKHGVVEDDGLAGVGCRVQPGQIYVNKQTPTNALDNSITLGHTQTVESGYKATPMTYKAPEPGYIDKVMLTTTDSDQTLIKVLMRQTRRPELGDKFSSRHGQKGVCGVIVQQEDMPFNDQGICPDIIMNPHGFPSRMTVGKMIELLSGKVGVLRGTLEYGTCFGGTKVEDASRILVEHGYNYSGKDMLTSGITGETLEAYIFMGPIYYQKLKHMVMDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIAYGASQLLLERLMISSDACDVDVCGQCGLLGYKGWCNSCQSTREVVKMTIPYAAKLLFQELLSMNIVPRLALEDEFKY
Protein: Kinesin-like protein (A0A8I6GCQ1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
ICDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDNEEGELGEDGEKRKKRRGKKKVSPDKMMEMQAKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSLMKLERPRTSKGKARPKTGRR
Protein: Ethanolamine phosphotransferase (Q388R8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MGVVDLLTSTRCEDLSSPVVPQLSYLFEYVLSPVYKYAASLYPTTWTPNKVTLTGIFATVVSSLLLLTAMPLNTFFEPPFATFVPGSYFLIKSPKWMDAPGPSPLYPSMLQPYFNSVFTPTSMLLLCGFLNLIYCVADNTDGCLARRLKKTSNIGEYLDHGLDCVTSLMSTCVSMSVLGFSFSNVAVTTALVALPTILSHTLHYEKNIFIWGNRFVSVDEAMLFFFLTSWISLMFPNVGKATFSPALLNAVLPESWARQLIPLRCIDAGLVVCWISQCFVLVNIGAKSKSMFLRLPTIMLVLNLALLLAIIPCHAVHIEKGGYGTYTLGPFSYVALWIITMACTCSSIVHIPIYAHCAKLPQTDPLPLAGVILVCLIFVSCPPTAAVLAVVCHVGQIWWNVRNLEGSVRKVE
Protein: glutathione transferase (EC 2.5.1.18) (C8BLR6)
Organism: Meleagris gallopavo (Wild turkey)
Interaction partners:
Sequence:
MAAKPVLYYFDGRGKMESIRWLLAAAGVEFEEVFLETREQYEKLLQSGVLMFQQVPMVEIDGMKLVQTRAILNYIAGKYNLYGKDLKERALIDMYVGGTDDLMGFLLSFPFLSAEDKVKQCAFVVQKATSRYFPAYEKVLKDHGQDFLVGNRLSWADIHLLEAILMLEEKKSDALSGFPLLQAFKKRISSIPTIKKFLAPGSKRKPISDDKYVETVRRVLRMYYDVKPN
Protein: FI17823p1 (Rho GTPase activating protein at 54D, isoform A) (Rho GTPase activating protein at 54D, isoform C) (A1ZAW3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Rho GTPase activating protein at 16F, isoform E
- Rho GTPase-activating protein 39
- Rho GTPase-activating protein 190
- Rho GTPase activating protein at 71E, isoform D
- GTPase-activating protein CdGAPr
- Ras-like GTP-binding protein Rho1
Sequence:
MEATMDTDHANLNDFRDRDLATRMRRCNYEKYKSLVRMHLSFELELNTDEFDLPCHEIVYEDKGKLKKWNRLSKKHRLGHGAAATSCAAGSASKSVGNSPTETLQQQIDPGFLMHLQELKEFLMLEKNLTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSAHDCATVFKGFLSELPEPLLTDAHYPAHLQIAPLCQALNGQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIEMLHAVAKHEKSNKMSADNLATLFTPHLICPRQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGKLSTDIRAYFLERKRKKTMSPEQTLDESISDVSTVNTVYTFVDRAATAAATNTNNTDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQGTPLQLVVMNRLKNNEATRSAKSLGDSIKKHIFHKSLMSRTPKRVPPSFHLASGSETPNMSHVKPPKMRVLFQSPTPPTPTSSTITSVSLSTNTRHQLQKSISSASLKIESSSSDSSSSCATSGSISAPVSRQQSKESPSGNGAAGASGQELDEIDADCCVTPLKIMSAVAKQLIDKKSVAWDEHRLLEIEEYSNPSTPVQQSTRYKSEPNLSSILPQVDAEEEDDGALTPIVEGRSTMVASSSHMGRSITRKLMKGVSMGNLRFPFSTPETTKRLVRSVSATLRRRPSGEESKPCPLAADAPLLEDVDDSDEDDDHHGAVDEDDDDTLSENNGSSNELPAMSLGYQQILQSSVYRNMDLITSTPALHLGRRSMSPITKSTQRMPKAMQESIMTPRSRKPVMLLTALAGNGDKQLNLSFAEQDEPDSIGGTPTKQLEPPSLHSEDATSLGGYADILGQHQSFALFNPRERTTSSSNSNEDSKPSNALSSDFKEYLLTRSVLTASPADLSFASRSDDFGGASTTQDIDDLDESDLSPSLLYCLDGNEPTLASPFGNSNGRKRSAGTPLKSTLITNLDADNKENMENLQEDHSRTKKLLITSPEKYPGETAL
Protein: Thiamine transporter THI72 (Q08579)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Low affinity thiamine transporter responsible for intake of thiamine. It is possible that the primary function is the uptake of closely related compounds and that thiamine transport is a secondary activity of these proteins.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized protein YOR097C
Sequence:
MSFGTRISRALRFLEIPVKNRASVNFLRNPDLQPIKSVNQTWGFWSNFAYWGVLSFNVGMWIGGSSALTVGLSYSETIGAFIIADLLTILFALANSCPGYDWKVGFTLAQRFVFGIYGSALGIIIRILMSIVYYGSNAWLGGLCVNMILDSWSHHYLHLPNTLSSKVAMTTKELIGFIIFHILTAFCYFMKPYHMNYILIWSCVGTFFAMLGMVIYLTKSAHGVGDLFTSTHSTVTGSKKAWAWVYTISYWYGSVSPGCTNQSDFSRFGSSNCAIWTGTIVALLIPATLIPVFGIIGASACEKLYGQTFWMPMDIFDNWLTTNYSAGARAATFFCGFCFVMSQISYTISNCGFASGMDLAGLLPKYVDIKRGAIFAACVSWACLPWNFYNSSSTFLTVMSSFGVVMTPIITVMICDNFLIRKRQYSVTNAFVLKGEYYFTKGVNWRAIVAWVCGMAPGLPGIAWEVNNDYFHNTGIINFFYGDSFFSFLISFFVYWGLCLLFPFKITVKHDDKDYYGAFTDEEARKKGMVPYSEISEEEIRAYTLGECFTSGHEYKPESSDDELPELTKTSSENTKVFEIVHQKDNEKESSTSSEKQIA
Protein: Ataxin-1-like (Brother of ataxin-1) (P0C7T6)
Organism: Mus musculus (Mouse)
Function: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). Can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development.
Subcellular location: Nucleus {ECO:0000269|PubMed:16121196}. Cell projection, dendrite {ECO:0000269|PubMed:16121196}. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
Interaction partners:
- Ataxin-1
- Recombining binding protein suppressor of hairless
- Histone acetyltransferase KAT5
- Recombining binding protein suppressor of hairless-like protein
- Pumilio homolog 2
- Pumilio homolog 1
- Protein capicua homolog
Sequence:
MKPVHERSQECLPPKKRDLPVTSEDMGRTTSCSTNHTPSSDASEWSRGVVVAGQSQTGARVSLGGDGTEAITGLTVDQYGMLYKVAVPPATFSPTGLPSVVNMSPLPPTFNVASSLIQHPGIHYPPVHYAQLPSTSLQFIGSPYSLPYAVPPNFLPSPLLSPSANLATTHLPHFVPYASLLAEEATPPPQAASPAQSFNKSSSATSPPGQLPHHSNTQPLDLAPGRMPIYYQMSRLPAGYTLHETSTAGASPILTPQEGQSALEAAAANGQRQRERNVRRESEALDSASSKGESQGLVPVVECMADGQLFSGSQTPRVEVAAPAHRGTPDTDLEVQRVVGALASQDYRVVAAQRKDEPSPLNLSHHNLDHQGEGRGSARNPTELVEKSQARVFYPQSHQEPVKHRPLPKAMVVANGNLVPTGTDPSLLPVGSEILVASSLDLQARATFPDKEPTPPPVTSSHLPSHFMKGAIIQLATGELKRVEDLQTQDFVRSAEVSGGLKIDSSTVVDIQESQWPGFVMLHFVVGEQQSKVSIEVPPEHPFFVYGQGWSSCSPGRTAQLFSLPCHRLQVGDVCISISLQSLNSNSVSQASCAPPGQLGTPRERPERTVLGPRDLCDSEGKNQPSGEGSRVGEPSQPEPGAQACWPAPSFQRFSMQGEEARAAMLRPSFIPQEVKLSIEGRSNAGK
Protein: Uncharacterized protein (Q18074)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MELLTSPSFHHISPLTRSRSDVRSAAMRRSNSFSGVTRSTSSNRFSRPEYGYGGGYMARSINKCGGSIFGRSLAASALTTTPPFHSVGVQRSTPHYTDKYPYVRYSYGNTDTGLGILTQSESVYGHHSGIRDIGTKRWLEGKLNAYNTSLFTRPDYQKRVERPLASARSYVRYMPVDDALDMYKKRCMTVGTLSKYWLSPATWASRREKELNLSSSLSRGNYSYSSRFDRLGGRVY
Protein: Complement C1q tumor necrosis factor-related protein 1 (G protein-coupled receptor-interacting protein) (GIP) (Q9BXJ1)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Vasopressin V2 receptor
- Complement C1q tumor necrosis factor-related protein 6
Sequence:
MGSRGQGLLLAYCLLLAFASGLVLSRVPHVQGEQQEWEGTEELPSPPDHAERAEEQHEKYRPSQDQGLPASRCLRCCDPGTSMYPATAVPQINITILKGEKGDRGDRGLQGKYGKTGSAGARGHTGPKGQKGSMGAPGERCKSHYAAFSVGRKKPMHSNHYYQTVIFDTEFVNLYDHFNMFTGKFYCYVPGLYFFSLNVHTWNQKETYLHIMKNEEEVVILFAQVGDRSIMQSQSLMLELREQDQVWVRLYKGERENAIFSEELDTYITFSGYLVKHATEP
Protein: RH59310p (Spidey (EC 1.-.-.-, EC 1.1.1.330)) (Q9W3N1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- very-long-chain enoyl-CoA reductase
- Very-long-chain
- Very-long-chain
- RH09070p)
- Elongation of very long chain fatty acids protein
- Very long chain fatty acid elongase 6
- Elongation of very long chain fatty acids protein
- Elongation of very long chain fatty acids protein
- Elongation of very long chain fatty acids protein
- Elongation of very long chain fatty acids protein
Sequence:
MEENNSQVLSLLGGLAIGIVGFQVFRKVLPWIYANVVGPKVFGSSVDLSKMGEWAVVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGGDEIYDKIREKTTGLNVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILIQSVQPGFVATNMSKIRKASVFAPSPETYVRSALSTLGIATQTAGYLPHALLQLVIHFTEAVFGEQFARNIVMKNILGTRKRALRRLAKEQ
Protein: Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2) (Q8N3J6)
Organism: Homo sapiens (Human)
Function: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17967169}; Single-pass type I membrane protein {ECO:0000269|PubMed:17967169}. Synapse {ECO:0000269|PubMed:17967169}. Cell projection, axon {ECO:0000269|PubMed:17967169}. Note=Found in the axoplasm of myelinated axons.
Interaction partners:
- Cell adhesion molecule 1
- Protein 4.1
Sequence:
MIWKRSAVLRFYSVCGLLLQGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI