wanglab/gogpt-training-data huggingface dataset:
Protein: PHD finger protein Alfin1 (Q40359)
Organism: Medicago sativa (Alfalfa)
Function: Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes (By similarity). Transcriptional regulator that binds specifically to DNA sequences 5'-GNGGTG-3' or 5'-GTGGNG-3', including promoter elements of the salt-inducible PRP2 gene. Plays a role in salinity tolerance.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MEGMAQHPVPRTVEEVFSDYKGRRAGLIKALTTDVEKFYQLVDPEKENLCLYGFPNETWEVNLPVEEVPPELPEPALGINFARDGMQEKDWLSLVAVHSDSWLLAVAFYFGARFGFGKNDRKRLFQMINDLPTVFELATGTAKQSKDQLTAHNNGSNSKYKSSGKSRQSESQTKGVKMSAPVKEEVDSGEEEEEDDDEQGATCGACGDNYGTDEFWICCDMCEKWFHGKCVKITPAKAEHIKQYKCPGCSIKKPRIG
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (Q7KPX5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAERPKNLFATGSSRSRNPPDQLSLNNLSIRHPPSSTSSTSSGSTSSGSSSSSQHNHVTRCFGAQQPQQTPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGAANTHTFTSDDLEDEGEIGRGAFGAVNKMIFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYVADILESMEKDGITQFTANQQAES
Protein: Leucine-rich repeat protein (LRRP), putative (Q57XT1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MNYISMGQRMAQRIRIDQSHRHHAITSNHLVDLRNETHNHALSAQCYTRLYCPKSLGVQLHFFPKPSFLTSLKSPFPPFYTIHTLSLTKNTKGKGGGAMVKRLGSEGGEQMVTNEDVEKLREEVAELRNHVHMVAAEHEKLREEYDEYRRRPVTWKAVINCDKNAPLECDDPADVIVVDDPGFNLKELSSLKGDVGELRLRRCCGRLDLELLSNQGLYLLEIGPGAVANMSCIGKFPCLQTLILHGTRLDNEWEKGVESLEKLREIVMKNISMLQDAKFLGNALFLDSITIENCPNMNAFTDTLTWPILRRLVITGTSLIVGNGLVEYFHDCVSLKVLRLGDCSAVHSKISLKNCKKLVELCLDNVGVRSTFEWGTELPLLRVLRLTNSSVTDADVKALSAFTTLEEVILSGNKEIVDISPLTNLRSLKVLDLSLCSRARIVGPVDCAPPLEKLLLRATAVTDECVGKLYSTSLSEVDLRFCSTLSKKTSKAIASLRNLRRLFLDDSPEVVFPGRRSPLETLGLCSGSASTTTLETICESATNLTCLRLWYCGGELNVSKLASPKKLRELYICGLRSVSEFAAIASLPELSKLILEGPFVGNKEIEDLSRCEALRSLCVRNAKHLTHVDPVFAIKTLEELSLSDCELLEKISADKSAIRSCVLRLCAIPIAAEGLKKLASQKAIGRLLLERCGSIRLDDIIGVPCTLTDCKEIVCDHMPIPPKIHTVRTPVVVLESAKNRHGW
Protein: Replication protein A 32 kDa subunit C (OsRPA32C) (OsRPA32-3) (Replication factor A protein 2C) (Replication protein A 2C) (Q5Z8L1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Replication protein A 70 kDa DNA-binding subunit C
- Replication protein A 70 kDa DNA-binding subunit B
- DNA primase large subunit
- Os05g0358200 protein
- Replication protein A 70 kDa DNA-binding subunit A
- Os01g0660500 protein
- ATP-dependent DNA helicase
- DNA polymerase alpha catalytic subunit
- DNA polymerase alpha subunit B
- Proliferating cell nuclear antigen
Sequence:
MAAAASYFSGTALMPSQRSGAPAPEYSAAGTGAAAAPSPSKPRDPRFSGCVPATVLHISRSFAAALAADGGGDPVFSIDGVETTNVRVLGRVVSVVSRDTDVCFTLDDSTGKIPLVRWITDQSDTRDTSYIQEGVYVKVQVNLMGFQAKKQGLARSIRPINNFNEVVLHFIECMHVHLESVQSKMQRQLPPSVQTNEYTHVPSSGGVRDYQVHFTPQVNQGLPPAVQTNTSTYVPLLGGVRDHQAHFAQVNQGQFSPAVQANTSTHLPFSGGVGEHQIHFTPKVNQGQFPPSVQTNTSAHVPYSGGFREHQVHFTPPVNQGQFPPAVQTNLYNHAASSGGVREQVHLTQANQFSAYSSTGGLQHDPQRMVLEALQQPDILALEHGAHVDELVRRTGMPKANIMGVVKHLAAAGFVYWTIDDNHVKSMCNG
Protein: Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20) (P46151)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Methylenetetrahydrofolate reductase 2
- Serine hydroxymethyltransferase, mitochondrial
- Aminomethyltransferase, mitochondrial
- Methylenetetrahydrofolate dehydrogenase [NAD
- Serine hydroxymethyltransferase, cytosolic
- C-1-tetrahydrofolate synthase, mitochondrial
- C-1-tetrahydrofolate synthase, cytoplasmic
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Thymidylate synthase
- Cystathionine beta-lyase
Sequence:
MSIRDLYHARASPFISLEFFPPKTELGTRNLMERMHRMTALDPLFITVTWGAGGTTAEKTLTLASLAQQTLNIPVCMHLTCTNTEKAIIDDALDRCYNAGIRNILALRGDPPIGEDWLDSQSNESPFKYAVDLVRYIKQSYGDKFCVGVAAYPEGHCEGEAEGHEQDPLKDLVYLKEKVEAGADFVITQLFYDVEKFLTFEMLFRERISQDLPLFPGLMPINSYLLFHRAAKLSHASIPPAILSRFPPEIQSDDNAVKSIGVDILIELIQEIYQRTSGRIKGFHFYTLNLEKAIAQIVSQSPVLSHIVNESSEEEGEDETSGEIGSIENVPIEDADGDIVLDDSNEETVANRKRRRHSSLDSAKLIFNRAIVTEKGLRYNNENGSMPSKKALISISKGHGTLGRDATWDEFPNGRFGDSRSPAYGEIDGYGPSIKVSKSKALELWGIPKTIGDLKDIFIKYLEGSTDAIPWSDLGLSAETALIQEELIQLNYRGYLTLASQPATNATLSSDKIFGWGPAKGRLYQKAFVEMFIHRQQWETTLKPKLDHYGRRKFSYYAGDSSGSFETNLDPHSSSVVTWGVFPNSPVKQTTIIEEESFKAWRDEAFSIWSEWAKLFPRNTPANILLRLVHKDYCLVSIVHHDFKETDELWEMLLDQA
Protein: ADP-ribosylation factor (Q6ID97)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555, ECO:0000256|RuleBase:RU369003}.
Interaction partners:
- Arginine-glutamic acid dipeptide repeat protein
- Solute carrier family 35 protein
- Kinesin-like protein KIN-14E
- Ras-related protein RABA1d
- Ras-related protein RABH1e
- Phosphatidylinositol 4-kinase beta 1
- UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
- ATPase GET3C
- non-specific serine/threonine protein kinase
- Probable quinone oxidoreductase
Sequence:
MGLSFAKLFSRLFAKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIASKA
Protein: Intraflagellar transport protein 70A2 (Tetratricopeptide repeat protein 30A2) (TPR repeat protein 30A2) (A2AKQ8)
Organism: Mus musculus (Mouse)
Function: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
Subcellular location: Cell projection, cilium {ECO:0000250}.
Interaction partners:
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 80 homolog
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 56
- Intraflagellar transport protein 172 homolog
- TRAF3-interacting protein 1
Sequence:
MAGLSNSQIPDGEFTAVVYRLIRDSRYSEAVQLLSAELQRSSRSRAGLSLLAYCYYRLQEFELAAECYEQLSQMHPELEQYRLYQAQALYKACLYPEATRVAFLLDNPTFYSRVLRLQAAIKYSEGDLPGARSLVEQLLSGEAGEDSGGENDPDGLVNMGCLLYKEGHYEAACSKFFAALQASGYQPDVSYNLALACYSNRHYAPALKHIANIIERGIRQHPELGVGMTTEGIDVRSVGNTVVLHQTALVEAFNLKAAIEYQLRNYEAAQEALTDMPPRAEEELDPVTLHNQALMNMDAKPTEGFEKLQFLLQQNPFPPETFGNLLLLYCKYEYFDLAADVLAENAHLTYKFLTPYLYDFLDAMITCQTAPEEAFIKLDGLAGMLTEQLRRLTKQVQEARHNRDDEVVIKAVNEYDETLEKYIPVLMAQAKIYWNLENYPMVEKIFRKSVEFCNDHDVWKLNVAHVLFMQENKYKEAIGFYEPIVKKNYDNILSVSAIVLANLCVSYIMTSQNEEAEELMRKIEKEEEQLSYGDPDKKIYHLCIVNLVIGTLYCAKGNYDFGISRVIKSLEPYHKKLGTDTWYYAKRCFLSLLENMSKHTIMLRDSVIQECVQFLEHCEIFGRNIPAVIEQPLEEERMHIGKNTVTYESRQLKALIYEIIGWNM
Protein: Clusterin (E7ERK6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTY
Protein: 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase) (EC 2.4.2.52) (P77231)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.
Interaction partners:
- [Citrate [pro-3S]-lyase] ligase
- Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
- Citrate lyase acyl carrier protein
- Citrate lyase subunit beta
- Citrate lyase alpha chain
- Citrate/succinate antiporter
Sequence:
MSMPATSTKTTKLATSLIDEYALLGWRAMLTEVNLSPKPGLVDRINCGAHKDMALEDFHRSALAIQGWLPRFIEFGACSAEMAPEAVLHGLRPIGMACEGDMFRATAGVNTHKGSIFSLGLLCAAIGRLLQLNQPVTPTTVCSTAASFCRGLTDRELRTNNSQLTAGQRLYQQLGLTGARGEAEAGYPLVINHALPHYLTLLDQGLDPELALLDTLLLLMAINGDTNVASRGGEGGLRWLQREAQTLLQKGGIRTPADLDYLRQFDRECIERNLSPGGSADLLILTWFLAQI
Protein: SMN protein (Tudor domain-containing protein) (G5EFQ8)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEVDDVWDDTELIKMYDESLQEISKNETSAKITSRKFKGEDGKMYTWKVGGKCMAPYEENGEVTDYPATIDTIGGADNLEVGVTFIYYGGQAVVQMKDLWLNEEAIADAVKAENDLQKTKKTSTVNSVAHSNSKSTSSAPNTSMPFPSFAPPVPPNIIAMAPVNQKEAMNSMLMSWYMSGYHTGYYQALADQKNVQN
Protein: Lysophospholipase (Q7YXI0)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MFGTPVENLTANQIKEELRTLYGVSDFSGCIEQKDLQEKLEKTRETELITHGLKYGPLLQIGNRQSPSGIVTLTHGLGDSANGWESVAVELSRRLPHLLFLLPTASMQPVGINGGAVMNSWYDIRNVSSGNGVTEDAEAIIMSANYLKSLAYTASRRYQVPAGRVVYAGFSQGAVISLAAGLTARIAPAGVAALSGYFAAAEKILPQLCNKSLPVLLCHGTMDNIIPFSAAEKTKETLESLGVGPVTLYSYPMEHSSHPKEINDLEKFLQQVLPGPSSKS
Protein: Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein) (Q494U1)
Organism: Homo sapiens (Human)
Function: Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:25043870}; Lipid-anchor {ECO:0000269|PubMed:25043870}. Mitochondrion {ECO:0000269|PubMed:27616329, ECO:0000269|PubMed:29531808}. Mitochondrion membrane {ECO:0000269|PubMed:18191643, ECO:0000269|PubMed:29180010}. Note=Interaction with C1QBP and phosphorylation is essential for its mitochondrial localization. Localizes on the microtubule in the form of small granules. {ECO:0000269|PubMed:18191643}.
Interaction partners:
Sequence:
MGNSHCVPQAPRRLRASFSRKPSLKGNREDSARMSAGLPGPEAARSGDAAANKLFHYIPGTDILDLENQRENLEQPFLSVFKKGRRRVPVRNLGKVVHYAKVQLRFQHSQDVSDCYLELFPAHLYFQAHGSEGLTFQGLLPLTELSVCPLEGSREHAFQITGPLPAPLLVLCPSRAELDRWLYHLEKQTALLGGPRRCHSAPPQRRLTRLRTASGHEPGGSAVCASRVKLQHLPAQEQWDRLLVLYPTSLAIFSEELDGLCFKGELPLRAVHINLEEKEKQIRSFLIEGPLINTIRVVCASYEDYGHWLLCLRAVTHREGAPPLPGAESFPGSQVMGSGRGSLSSGGQTSWDSGCLAPPSTRTSHSLPESSVPSTVGCSSQHTPDQANSDRASIGRRRTELRRSGSSRSPGSKARAEGRGPVTPLHLDLTQLHRLSLESSPDAPDHTSETSHSPLYADPYTPPATSHRRVTDVRGLEEFLSAMQSARGPTPSSPLPSVPVSVPASDPRSCSSGPAGPYLLSKKGALQSRAAQRHRGSAKDGGPQPPDAPQLVSSAREGSPEPWLPLTDGRSPRRSRDPGYDHLWDETLSSSHQKCPQLGGPEASGGLVQWI
Protein: Palmitoleoyl-protein carboxylesterase NOTUM (EC 3.1.1.98) (Protein Notum) (Protein wingful) (dNOTUM) (Q9VUX3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Also acts as a regulator of long-range activity of Hedgehog (hh), possibly by regulating the switch between low and high level hh pathway signaling.
Subcellular location: Secreted {ECO:0000269|PubMed:12000788, ECO:0000269|PubMed:12015973, ECO:0000269|PubMed:25731175}. Cell surface {ECO:0000269|PubMed:25731175}. Note=Associates with the cell surface via interaction with sulfated CAG chains on glypicans. {ECO:0000269|PubMed:25731175}.
Interaction partners:
- Protein wingless
- Protein Wnt
- Protein Wnt-5
- Wnt inhibitor of Dorsal protein
- Division abnormally delayed protein
- Dally-like, isoform A
- Protein Wnt
- Protein hedgehog
Sequence:
MAVEQIDKMAAKAGEATNKWIKPQQPLLTLLLLLATFSQLPAVCSSSILDAASLQEKDPLRDTSMNMIQRNYMVMHSASGSGDHSRSLKRANLANTSITCNDGSHAGFYLRKHPSSKKWIVLLEGGWHCFDVRSCRSRWMRLRHLMTSSQWPETRDVGGILSPHPEENPYWHNANHVLIPYCSSDSWSGTRTEPDTSDRENSWRFMGALILRQVIAELIPVGLGRVPGGELMLVGSSAGGMGVMLNLDRIRDFLVNEKKLQITVRGVSDSGWFLDREPYTPAAVASNEAVRQGWKLWQGLLPEECTKSYPTEPWRCYYGYRLYPTLKTPLFVFQWLFDEAQMRVDNVGAPVTPQQWNYIHEMGGALRSSLDNVSAVFAPSCIGHGVLFKRDWVNIKIDDISLPSALRCWEHSTRSRRHDKLKRSTEPSTAVSHPEHANNQRHQRHRQRLQRQKHNNVAQSGGQQRKHNHLSKEEREERKRLRQEQRQRRKQRRRQQQQKKANGGQEHRNKKDNSPKSSNGNDQRKQRRRQQLTAEERQEQRKRRRKAQQQQMKMQREQPAAGVFLEASAPQKTRSSNNASAGTKSKKRHRVPRVPEKCGLRLLERCSWPQCNHSCPTLTNPMTGEEMRFLELLTAFGLDIEAVAAALGVDMHTLNNMERTELVNMLTQQAN
Protein: Vacuolar sorting protein 18 (F4IDS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein required during embryogenesis. Believed to act as a core component of the putative HOPS endosomal tethering complex and of the class C core vacuole/endosome tethering (CORVET) complex. CORVET is required for vacuolar transport of SYP22. HOPS is required for the central vacuole formation. Involved in root development. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (By similarity).
Subcellular location: Endosome membrane {ECO:0000250|UniProtKB:Q9P253}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9P253}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9P253}. Vacuole membrane {ECO:0000269|PubMed:29463724}; Peripheral membrane protein {ECO:0000269|PubMed:29463724}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9P253}. Cytoplasm {ECO:0000269|PubMed:29463724}. Note=Co-localizes with VPS39 at subdomains of the vacuolar membrane, and with VPS3 and RABF2B at punctate compartments in the cytoplasm, with faintly dispersed distribution in the cytosol. Sometimes observed at the vertex zone, the ring-shaped edge of vacuole-vacuole contact sites. Co-localizes with RABG3F. {ECO:0000269|PubMed:29463724}.
Interaction partners:
- Protein VACUOLELESS1
- Vacuolar protein-sorting-associated protein 33 homolog
- Vacuolar sorting protein 3
- Vacuolar sorting protein 39
- Vacuolar protein-sorting-associated protein 11 homolog
- Vacuolar protein sorting-associated protein 41 homolog
- Transducin family protein / WD-40 repeat family protein
- Vacuolar fusion protein CCZ1 homolog A
- Syntaxin-22
- Vesicle-associated membrane protein 727
Sequence:
MDQGRQVFSVDLLERYATKNRGMITCMAAGNDVIVLGTSKGWIIRYDFGVGSSNDIDLAVGRTGEQSIHKVFVDPGGSHCIATVTGVGGAETFYTHAKWLKPRVLSRLKGLLVNAVAWNRQQITEVSTKEIILGTQDGQLFEMAVDEKDKREKYIKFLFELEELPEAFKALQMETANISSGMRYYVMAVTPTRLYSFTGIGTLESVFASYKERAVHFMELPGEIPNSELHFFIKQRRAVHFAWLSGTGIYHGGLNFGAQHSYPNGDENFVENKALLDYSKLSDGTEAVKPGSMALSEYHFLLLIGNKVKVVNRISEQIIEELQFDITSDSVSRGIIGLCSDASANVFYAYDQNSIFQVSVIDEGRDMWKVYLDLKVYAAALANCRDPLQRDQVYLVQAESAFTDKEYLRAASFYAKINYVISFEEVTLKFISINEPEALRTFLLHKLDNLSKDDKCQITMISTWATELYLDKINRLLLEDDTAIENRDSEYHSVIQEFRAFMSDCKDELDEATTVKILESYGRVEELVYFANLKEQYEIVVLHYIQQGEAKKALEVLQKSSVSVELQYQFAPELIMLDAYETVESWMANKNLNPRRLITAMMRYSSGPHAKNETHEVIKYLEFCVHRLHNEDPGIHSLLLSLYAKQEDDGALLRFLQCKFGKGRENGPEFFYDPKYALRLCLKERRTRACVHIYSMMSMHEEAVALALQIDPELAMAEADKVEDDEDLRKKLWLMVAKHVVKQEKGAKRENIRKAIAFLKETDGLLKIEDILPFFPDFALIDDFKEAICSSLEDYNKQIEQLKEEMNDATRGADNIRNDISALTQRYAVIDRDEECGVCKRKILMMSGDFRMAQGYSSAGPLAPFYVFPCGHSFHAQCLITHVTSCAHEEQAEHILDLQKQLTLLGSETRRDINGNRSDEPITSTTTADKLRSELDDAIASECPFCGELMINEITLPFIKPEDSQYSTSWDLRSETNLANQRTISLPV
Protein: Protein IL-40 (Interleukin-40) (IL-40) (Q6UX52)
Organism: Homo sapiens (Human)
Function: Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses. Involved in lymphocyte B cell development and immunoglobulin/IgA production.
Subcellular location: Secreted {ECO:0000269|PubMed:28978694}.
Interaction partners:
Sequence:
MGLPGLFCLAVLAASSFSKAREEEITPVVSIAYKVLEVFPKGRWVLITCCAPQPPPPITYSLCGTKNIKVAKKVVKTHEPASFNLNVTLKSSPDLLTYFCWASSTSGAHVDSARLQMHWELWSKPVSELRANFTLQDRGAGPRVEMICQASSGSPPITNSLIGKDGQVHLQQRPCHRQPANFSFLPSQTSDWFWCQAANNANVQHSALTVVPPGGDQKMEDWQGPLESPILALPLYRSTRRLSEEEFGGFRIGNGEVRGRKAAAM
Protein: Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (PAM COOH-terminal interactor protein 2) (P-CIP2) (U2AF homology motif kinase 1) (P97343)
Organism: Mus musculus (Mouse)
Function: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12093740}. Note=Mostly nuclear.
Interaction partners:
- Cyclin-dependent kinase inhibitor 1B
- Stathmin
Sequence:
MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPGRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL
Protein: C-type lectin domain family 18 member B (Mannose receptor-like protein 1) (Q6UXF7)
Organism: Homo sapiens (Human)
Function: Binds polysaccharides in a Ca(2+)-independent manner (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:A5D8T8}. Endoplasmic reticulum {ECO:0000305|PubMed:26170455}. Golgi apparatus {ECO:0000305|PubMed:26170455}. Endosome {ECO:0000305|PubMed:26170455}.
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
Sequence:
MLHPETSPGRGHLLAVLLALLGTTWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGIPTPSLASGLWRTLQVGWNMQLLPAGLASFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQTAIEAFVCAYSPGGNWEVNGKTIIPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGLVWLSAAMGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS
Protein: CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] (O15519)
Organism: Homo sapiens (Human)
Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Interaction partners:
- FAS-associated death domain protein
- Caspase-8
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Receptor-interacting serine/threonine-protein kinase 1
- Caspase-10
- Tumor necrosis factor receptor superfamily member 6
- Ubiquitin-like-conjugating enzyme ATG3
- E3 ubiquitin-protein ligase Itchy homolog
- Receptor-interacting serine/threonine-protein kinase 3
- Tumor necrosis factor receptor superfamily member 10B
Sequence:
MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT
Protein: Type II secretion system protein H (General secretion pathway protein H) (Q9HVN0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004377}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004377}.
Interaction partners:
- Type 4 fimbrial biogenesis protein PilV
- Type IV pilus biogenesis factor PilY1
- Type 4 fimbrial biogenesis protein PilW
- Type 4 fimbrial biogenesis protein PilX
- Type IV pilus non-core minor pilin PilE
- Type 4 fimbrial biogenesis protein PilY2
- Type IV pilus inner membrane component PilN
- Type IV pilus inner membrane component PilO
- Fimbrial assembly protein PilQ
- Type IV pilus inner membrane component PilM
Sequence:
MVERSQRALTLTELLFALVLLGILGSLALPGMAAWLDGNRERSVLHELSASIQLGRTHAVAYQRPVTLCPSTDGRHCGSDWGEGWLLAEDGGERLLVGRALAKKERLLWNRSNRLRFLPSGQLNIHNGRFLLCGRHTVAWQLILNRQGRLRTASARENREKRELCSTSG
Protein: Protein arginine methyltransferase NDUFAF7 (EC 2.1.1.320) (Q1JPN1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|RuleBase:RU364114}.
Interaction partners:
- Putative methyltransferase At1g22800, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 9
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- Complex I assembly factor TIMMDC1, mitochondrial
- At1g62730
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- At1g72040
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 2
Sequence:
MLRKLLTQTSSRRLLFSGVPPLFSKSTISPFSSLSSSPEPPSSESPAVEHPGTTISIDRSSLYTPPDHSHESTPDSELVKHLKSIIKFRGGPISVAEYMEEVLTNPKAGFYMNRDVFGAQGDFITSPEVSQMFGEMIGVWTVCLWEQMGRPERVNLVELGPGRGTLMADLLRGTSKFKNFTESLHIHLVECSPALQKLQHQNLKCTDESSSEKKAVSSLAGTPVHWHATLQEVPSGVPTLIIAHEFYDALPVHQFQKSTRGWCEKMVDVGEDSKFRFVLSPQPTPAALYLMKRCTWATPEEREKMEHVEISPKSMDLTQEMAKRIGSDGGGALIIDYGMNAIISDSLQAIRKHKFVNILDDPGSADLSAYVDFPSIKHSAEEASENVSVHGPMTQSQFLGSLGINFRVDALLQNCNDEQAESLRAGYWQLVGDGEAPFWEGPNEQTPIGMGTRYLAMSIVNKNQGIPAPFQ
Protein: Beta-fructofuranosidase, insoluble isoenzyme CWINV3 (6-fructan exohydrolase) (6-FEH) (EC 3.2.1.80) (Beta-fructofuranosidase 5) (AtFruct5) (Cell wall beta-fructosidase 3) (Cell wall invertase 3) (AtcwINV3) (Sucrose hydrolase 3) (Q67XZ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: 6-fructan exohydrolase that can use phlein, levan, neokestose, levanbiose, 6-kestose, and 1-kestose as substrates.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}. Secreted, cell wall {ECO:0000305}. Note=Associated to the cell wall. {ECO:0000305}.
Interaction partners:
- alpha-D-xyloside xylohydrolase
- Probable galactinol--sucrose galactosyltransferase 4
- Probable fructokinase-1
- Probable fructokinase-2
- Probable fructokinase-6, chloroplastic
- Probable fructokinase-3
- Probable fructokinase-7
- Probable fructokinase-5
- Probable fructokinase-4
- Hexokinase-1
Sequence:
MAKLNRSNIGLSLLLSMFLANFITDLEASSHQDLNQPYRTGYHFQPLKNWMNDPNGPMIYKGIYHLFYQYNPYGAVWDVRIVWGHSTSVDLVNWISQPPAFNPSQPSDINGCWSGSVTILPNGKPVILYTGIDQNKGQVQNVAVPVNISDPYLREWSKPPQNPLMTTNAVNGINPDRFRDPTTAWLGRDGEWRVIVGSSTDDRRGLAILYKSRDFFNWTQSMKPLHYEDLTGMWECPDFFPVSITGSDGVETSSVGENGIKHVLKVSLIETLHDYYTIGSYDREKDVYVPDLGFVQNESAPRLDYGKYYASKTFYDDVKKRRILWGWVNESSPAKDDIEKGWSGLQSFPRKIWLDESGKELLQWPIEEIETLRGQQVNWQKKVLKAGSTLQVHGVTAAQADVEVSFKVKELEKADVIEPSWTDPQKICSQGDLSVMSGLGPFGLMVLASNDMEEYTSVYFRIFKSNDDTNKKTKYVVLMCSDQSRSSLNDENDKSTFGAFVAIDPSHQTISLRTLIDHSIVESYGGGGRTCITSRVYPKLAIGENANLFVFNKGTQSVDILTLSAWSLKSAQINGDLMSPFIEREESRSPNHQF
Protein: Katanin regulatory subunit B1 like 1 (H0YL62)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
KSPDKLRKVIYRRKKVHHPFPNPCYRKKQSPGSGGCDMANKENELACAGHLPEKLHHDSRTYLVNSSDSGSSQTESPSSKYSGFFSEVSQDHETMAQVLFSRNMRLNVALTFWRKRSISELVAYLLRNIQILKQQLSGLWEQENHLTLVPGYTGNIAKDVDAYLLQLH