wanglab/gogpt-training-data huggingface dataset:
Protein: Transcription factor HES-3 (Hairy and enhancer of split 3) (Q04667)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription.
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MEKKRRARINLSLEQLRSLLERHYSHQIRKRKLEKADILELSVKYVRSLQNSLQGLWLVPSGVDYPSGFRGGLPGSSQRLRPGEDDSGLRCPLLLQRRAGSTTDSANPQTASVLSPCLPAIWAPGPPAGGSQSPQSPFPPLGGLLESSTGILAPPPASNCQAENPRPGFRVWRPW
Protein: Large ribosomal subunit protein eL15B (60S ribosomal protein L15-B) (L13) (RP15R) (YL10) (YP18) (P54780)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS15
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL30
Sequence:
MGAYKYLEELERKKQSDVLRFLQRVRVWEYRQKNVIHRAARPTRPDKARRLGYKAKQGFVIYRVRVRRGNRKRPVPKGATYGKPTNQGVNELKYQRSLRATAEERVGRRAANLRVLNSYWVNQDSTYKYFEVILVDPQHKAIRRDARYNWICNPVHKHREARGLTATGKKSRGINKGHKFNNTKAGRRKTWKRQNTLSLWRYRK
Protein: Antitoxin SocA-like Panacea domain-containing protein (Q9A2P1)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Thioesterase domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MPPLTQDPQSVDARAVANLLLDKAAALDIPISNLALQKLLYFAHGRFLVDKGRPLVNGFFEAWKFGPVHPVVYRCFSANGPKYIINRAIKKDILSGLHIIVSPPRDQDIHEGIERVLLTMGRMSASQLVAVSHASGGPWDVIANGPGTNLGLGLRICDKVIKDRFRFQKVSVSVPPGLGDTLEEAPPS
Protein: Interferon regulatory factor 3 (F7EXX5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MLHTKTLSQNIHKNNVEKTKQKKRQQLGEDSGNELRNCTVCAGWIMGTPKPLILPWLVSQLDLGQLKGVAWLDESRTKFRIPWKHGLRQDAQMADFGIFQAWAEASGAYTPGKDKPDLSTWKRNFRSALNRKEVLRLAEDRSKDPFDPHKVYEFVTPGGARDFVHLDTSPDTNGKSSLSDHQEDLLELLDHMALGPLPDEGSSDLPIASDPSQPPLSPIVNNFPNPAPQENPLRQLLAEEQWEFEVTAFYRGRQVFQQTLFCPGGLRLVGSTSDNGTLPWQPVTLPDPEEFLTDRLVREYVRQVLKGLGKGLVLWRAGQCLWAQRLGHSHSFWALGEELLPDSGRGPDGEVPKDKNGVVFDLRPFVADLIAFMEGSRHSPRYTLWFCVGESWPQDQPWVKRLVMVKVVPTCLKELLEMAREGGASSLKTVDLHISNSQPISLTSDQYKACLQDLVEDMDFQATGET
Protein: UDP-glucuronic acid decarboxylase 6 (EC 4.1.1.35) (UDP-XYL synthase 6) (UDP-glucuronate decarboxylase 6) (UGD) (UXS-6) (Q9ZV36)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- UDP-glucose 6-dehydrogenase 3
- UDP-D-apiose/UDP-D-xylose synthase 1
- UDP-glucose 6-dehydrogenase 2
- UDP-D-apiose/UDP-D-xylose synthase 2
- UDP-sugar pyrophosphorylase
- UDP-glucose 6-dehydrogenase 1
- Cellulose synthase-like protein D5
- UDP-glucose 6-dehydrogenase 4
- Putative UDP-glucose 6-dehydrogenase
- UDP-glucuronate 4-epimerase 6
Sequence:
MASNSSNGTTTTKPPPMPSPLRNSKFFQSNMRILVTGGAGFIGSHLVDKLMQNEKNEVIVADNYFTGSKDNLKKWIGHPRFELIRHDVTEPLFVEVDQIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKRVGARILLTSTSEVYGDPLVHPQTESYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARIFNTYGPRMNIDDGRVVSNFIAQALRGEALTVQKPGTQTRSFCYVSDMVEGLMRLMEGDQTGPINIGNPGEFTMVELAETVKELIKPDVEIKMVENTPDDPRQRKPDISKAKEVLGWEPKVKLREGLPLMEEDFRLRLGVPKK
Protein: Replication factor A protein 2 (Single-stranded DNA-binding protein P30 subunit) (Q92373)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds to single-stranded sequences.
Subcellular location: Nucleus.
Interaction partners:
- Replication factor A protein 1
- Replication factor A protein 3
- DNA polymerase delta catalytic subunit
- DNA primase small subunit
- Proliferating cell nuclear antigen
- DNA polymerase subunit delta-2
- DNA primase large subunit
- Protein kinase rad3
- Replication factor C subunit 4
- ATP-dependent DNA helicase pfh1
Sequence:
MAYDAFGKPGYGPDFNSAFSPGMGGGAGFNEYDQSSQPSVDRQQGAGNKLRPVTIKQILNASQVHADAEFKIDGVEVGQVTFVGVLRNIHAQTTNTTYQIEDGTGMIEVRHWEHIDALSELATDTYVRVYGNIKIFSGKIYIASQYIRTIKDHNEVHFHFLEAIAVHLHFTQKANAVNGANAPGYGTSNALGYNNISSNGAANSLEQKLAEYSLTPAQMTVMQAIHSAPETNEGVHVRQLAQSVGPGIDLTAVTDFLQQEGIIYTTIDENHFKSVLQDQ
Protein: Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1) (Q969X1)
Organism: Homo sapiens (Human)
Function: Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269|PubMed:16607040}. Endosome membrane {ECO:0000269|PubMed:16607040}.
Interaction partners:
Sequence:
MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSVLPGGYPAYPGYPQPGYGHPAGYPQPMPPTHPMPMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN
Protein: Lmo2182 protein (Q8Y587)
Organism: Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}.
Interaction partners:
- Probable heme-iron transport system permease protein IsdF
- High-affinity heme uptake system protein IsdE
- Lmo2430 protein
- FhuB protein
- FhuG protein
- Sortase B
- Lmo0541 protein
- Lmo2431 protein
- Lmo1959 protein
- Lmo1073 protein
Sequence:
MEVRDVNFSYNGTDAILKNVSFTIQKNKINTIVGPNGSGKSTLLEILARLLSPNSGDVLLEGKSIFEWKAKEFAQNVAIVHQSNVLPNELMVKELLYFGRLPYKNWRMTRTKEDDLAVERALMQTELTEKAEKFVDSLSGGERQRVFIATALVQDTPILLLDEPTTFLDMYFQLEILELVKRLNQEENLTIVMILHDLNQALMYSDHLIVMKNGEVVAKGEPEELLTTDLIAETYGVVADVLNDANNGKYIVPQRRKEF
Protein: FIS1-related protein fis-2 (Mitochondrial fission 1 protein fis-2) (Q6AHP8)
Organism: Caenorhabditis elegans
Function: Involved in the fragmentation of the mitochondrial network (By similarity). Involved in perinuclear clustering of the mitochondrial network (By similarity). May act, redundantly with fis-1, downstream of mitochondrial fission, before the fission products participate in mitochondrial homeostasis, mitophagy, or apoptosis. Plays a role in apoptosis by promoting mitochondrial elimination and cell-death execution, acting downstream of caspase ced-3, and perhaps independently of dynamin GTPase drp-1, caspase ced-9 and apoptosis-inducing factor AIFM/wah-1.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9Y3D6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y3D6}. Peroxisome membrane {ECO:0000250|UniProtKB:Q9Y3D6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y3D6}. Mitochondrion {ECO:0000269|PubMed:18722182}.
Interaction partners:
- TBC1 domain family member 15
- Transmembrane GTPase fzo-1
- Dynamin-1-like protein drp-1
- Endoplasmic reticulum transmembrane protein
- Mitochondrial fission factor
- Dynamin-like GTPase OPA1, mitochondrial
- Mitochondrial fission factor
- Dynamin
- Serine/threonine-protein kinase pink-1, mitochondrial
- Putative peroxisomal biogenesis factor 19
Sequence:
MDYGTILEERTNPAVLMNAREQYMRQCARGDPSAASTFAFAHAMIGSKNKLDVKEGIVCLEKLLRDDEDRTSKRNYVYYLAVAHARIKQYDLALGYIDVLLDAEGDNQQAKTLKESIKSAMTHDGLIGAAIVGGGALALAGLVAIFSMSRK
Protein: Large ribosomal subunit protein eL18 (60S ribosomal protein L18) (Q07020)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q95342}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q95342, ECO:0000269|PubMed:25957688}.
Interaction partners:
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL21
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein eS26
- Elongation factor 2
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL3
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein eL28
Sequence:
MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN
Protein: Uncharacterized protein YqgB (P64567)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19121005}.
Interaction partners:
- Biosynthetic arginine decarboxylase
- Uncharacterized protein YceO
Sequence:
MKKKPVAQLERQHSLLENPCAYGLLSQFQAAIVVNCFTLNKII
Protein: Mediator of RNA polymerase II transcription subunit 16 (Global transcriptional regulator SIN4) (Mediator complex subunit 16) (SNF1 suppressor protein 4) (SWI4 suppressor protein 5) (Transcriptional silencing factor 3) (YGP1 expression regulatory protein 1) (P32259)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 3
- RNA polymerase II holoenzyme cyclin-like subunit
- Mediator of RNA polymerase II transcription subunit 5
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 2
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 17
Sequence:
MMLGEHLMSWSKTGIIAYSDSQSSNANICLTFLESINGINWRFHTPQKYVLHPQLHEVQYQESSSTLSTHSTTTSVNGSTTAGVGSTPNFGGNSNKSPPQFFYNISSIHWNNWFSLPGDMLAVCDELGNMTMLITGQRPDRATTYEKLTMVFQDNVYKIYNHVMPLKPVDKLKPMNIERKQTRKEYNTSILEFRWLTSSKSVIVSQFCAFDSSSNTYRSRAQQVPPYGVYHPPFIKYACLAIRKNGQIDFWYQFSNSKDHKKITLQLLDTSNQRFKDLQWLEFARITPMNDDQCMLITTYSKLSKNISFYKLHVNWNLNATKPNVLNDPSLKIQFILSTTLDPTDDEGHVLKLENLHVVSKSSIEKDPSPEILVLYNVCDTSKSLVKRYRLAPTQLSAEYLVILKPDLNIDRNNSTNQIFQSRRYNLRRHSDIVLDKKVTLITSEMFDAFVSFYFEDGTIESYNQNDWKLETERLISQSQLGKFKNIIASPLSAGFNYGKLPLPPSVEWMKVSPSMCGVIVKQYNKKWPQFYAAVQKNYADPEKDSINATALAFGYVKSLHKQISAEDLTIAAKTHILRISFLDRKRAKEFITTLLKSLYSFFNISPDAPKEIMDKIITSRPLQKIMLLQLELGSCFSQENIEEMARVILYLKNVLFAFNGVARNFHFAIEQISNNSNQQQNPKLFQTIFSKQDLIHSLIPVAKWFVKFITYLTQEILILINDPTNKEYTLVHGIFGAKMSRTLILSILNEIKKVTQIVAKFPETSYPILNESSTFLKLVLSESPVDFEKFETFLVDVNNKFIALCEQQPSQEREFSLLVKAEIPPEYAKVGDFLLQYANNAVISHANAAAVYFADTSGLKISNSEFFNPEIFHLLQPLEEGLIIDTDKLPIKNRTSKSFSKLLYDDVTCDKLSVSEISDGKLKRCSRCGSVTRAGNIISSDKTIVPTSIQTKRWPTMYTRLCICSGMLFEMDG
Protein: 2-amino-4-ketopentanoate thiolase beta subunit (EC 2.3.1.263) (AKP thiolase) (AKPT) (E3PY97)
Organism: Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / CCUG 9281 / NCIMB 10654 / HF) (Clostridium sticklandii)
Function: Involved in the ornithine fermentation pathway. Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine. It is strictly specific for AKP.
Interaction partners:
- 2-amino-4-ketopentanoate thiolase alpha subunit
- 2,4-diaminopentanoate dehydrogenase
- D-ornithine 4,5-aminomutase subunit beta
- D-ornithine 4,5-aminomutase subunit alpha
- Putative component of D-ornithine aminomutase
- Ornithine racemase
- Serine acetyltransferase
- Alanine racemase domain protein
- L-methionine gamma-lyase
Sequence:
MSKDMSYSGVMSRRNEIMKNAIGIDYTTFESGSLSFDYEKMMRETGYTLEEMQKIQYSTGVGRTPVLELRNITALARKYAAPGKGARIFIKDEAGNPSGSFKARRAANAVYHAKKLGYKGVIAATSGNYGAAVASQAAMAGLKCIIVQECYDSKGVGQPEIIEKARKCEALGAEVVQLSVGPELFYKFLSLLEETGYFNASLYTPFGIAGVETLGYELAVEFREAYGKDPDVVVCSNAGGGNLTGTARGLIKAGAQSEVVAASVNLQGLHMASDTQFNKKSFTTSHTGFGMPFATWPDRSDVPRSAARPLRYMDRYVTVNQGEVFYITETLASLEGLEKGPAGNTALAAAFSLAQEMDKDQIIVVQETEYTGAGKHIQPQLAFARDNGIDIKFGNPKEEVAGINIILPENPGMIKAVDHEMNKLRKSLIKNALANYPDAKLDDSDIDFLVKETKSDTEFVKATIKEIKG
Protein: Fatty acid-binding protein 5 (Differentiation-associated lipid-binding protein LP2) (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein, epidermal) (P55052)
Organism: Bos taurus (Bovine)
Function: Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9521644}. Nucleus {ECO:0000250|UniProtKB:Q01469}. Synapse {ECO:0000250|UniProtKB:Q05816}. Postsynaptic density {ECO:0000250|UniProtKB:Q05816}. Secreted {ECO:0000250|UniProtKB:Q05816}. Note=Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (By similarity). Secreted by astrocytes, but not by neurons (By similarity). {ECO:0000250|UniProtKB:Q01469, ECO:0000250|UniProtKB:Q05816}.
Interaction partners:
- Fatty acid-binding protein, adipocyte
- Gastrotropin
- Fatty acid-binding protein, liver
- Fatty acid-binding protein, heart
- Fatty acid-binding protein, brain
- PPARD protein
- Platelet glycoprotein 4
- Aspartate aminotransferase, mitochondrial
- Peroxisome proliferator-activated receptor gamma
Sequence:
MATVQQLVGRWRLVESKGFDEYMKEVGVGMALRKVGAMAKPDCIITSDGKNLSIKTESTLKTTQFSCKLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLEDGKLVVVCVMNNVTCTRVYEKVE
Protein: Collagen type XVIII alpha 1 chain (F1LR02)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- 72 kDa type IV collagenase
- Matrix metalloproteinase-9
- Collagen alpha-1
- Vascular endothelial growth factor receptor 2
- Collagenase 3
- Collagen alpha-1
- Collagen type IV alpha 1 chain
- Collagen type IV alpha 2 chain
- Nucleolin
- Collagen type IV alpha 3 chain
Sequence:
MAPRWHLLDMLTSLVLLLVARVSWAEPENVAEDVGLLQLLGDPLPQKISQVEDPHVGLAYVFGPYSKSSQMAQYHFPKLFFRDFSLLFEVRPTTEAAGVLFAITDAAQVVVSLGVKLSEVRDGQQNISLLYTEPGASQTQTGASFRLPAFVGQWTHFALSVDGSSVALYVDCEEFQRVPFARSPHGLELERGAGLFVGQAGAADPDKFQGMISELRVRKTPRVSPVHCLDEEDDDDDRASGDFGSGLEESSNLHRQETYLRPGLPQPPPVTSPPLAGGSATEDSRTEEKEEEATVDSKGADTLPVTDSSGVWDGDVQNPGGGLIKGGLKGQKGEPGAQGPPGPAGPQGPAGPAVQSPSSQPVPGAQGPPGPQGPPGKDGIPGRDGEPGDPGEDGRPGDTGPQGFPGTPGDVGPKGEKGDPGIGPRGPPGPPGPPGPSFRQDKLTFIDMEGSGGFSGDLESLRGPRGFPGPPGPPGVPGLPGEPGRFGVNSSYAPGPAGLPGVPGKEGPPGFPGPPGPPGKEGPPGVAGQKGSVGDAGSPGPKGSKGDLGPIGMPGKSGLPGLPGPVGPPGPPGPPGPPGPGFAAGFDDMEGSGTPLWSTARSSDGLQGDPGVTGPPGAKGEVGADGVQGIPGLPGREGVAGPPGPKGEKGTQGEKGNPGKDGVGRPGLPGPPGPPGPVIYVSNEDRAVVSTPGPEGKPGYAGFPGPAGPKGDLGSKGEQGLPGPKGEKGEPGSIFSPDGTALGQAQKGAKGEPGFRGPPGPYGRPGYKGEIGFPGRPGRPGTNGLKGEKGEPGEASLGFSMRGLPGPPGPPGPPGPPGVPVYDSNAFVESGRPGLPGQQGVQGPPGPKGDKGEVGPPGPPGQFPIDLFHLEAEMKGDKGDRGDAGRKGERGEPGAPGGGFFSSSVPGPPGPPGYPGIPGPKGESIRGPPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTVSVPGPPGPPGPPGPPGAMGASAGQVRIWATYQTMLDKIREVPEGWLIFVAEREELYVRVRNGFRKVLLEARTALPHGTDNEVAALQPPLVQLHEGSSYTRREHSYPTARPWRADDILANPPRLPDRQPYPGVPHHHHHHHHHHSSHEHRPPAHPSPSPAHTHQDFHPVLHLVALNTPLSGGMRGIRGADFQCFQQARAVGLSGTFRAFLSSRLQDLYSIVRRADRSSVPIVNLKDEVLSPSWDTLFSGSQGQLHSGARIFSFDGRDVLRHPAWPQKSVWHGSDPSGRRLMESYCETWRTEATGVTGQASSLLSGRLLEQKAESCHNSYIVLCIENSFMTSFSK
Protein: GEO12665p1 (Uncharacterized protein, isoform B) (Q8INK7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
Sequence:
MSSKSLFDSEEDAAQANKLSRKAKESPFMLVGITGFVAAGLIGAYKYRNRGTMSTSVFLMQLRVAAQGTVVGCLTLGLAYSMAKEYLFDKAPKEK
Protein: Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) (Q08170)
Organism: Homo sapiens (Human)
Function: Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:14578391}.
Interaction partners:
- Serine/arginine-rich splicing factor 10
- SRSF protein kinase 1
- Serine/arginine repetitive matrix protein 1
- Serine/arginine-rich splicing factor 1
- Serine/arginine-rich splicing factor 6
- Serine/arginine-rich splicing factor 2
- Serine/arginine-rich splicing factor 11
- Splicing factor U2AF 65 kDa subunit
- Serine/arginine-rich splicing factor 3
- Serine/arginine repetitive matrix protein 2
Sequence:
MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDLCGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS
Protein: Transmembrane gamma-carboxyglutamic acid protein 2 (NEDD4 WW domain-binding protein 1) (Proline-rich gamma-carboxyglutamic acid protein 2) (Proline-rich Gla protein 2) (Q8R182)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O14669}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Proline-rich protein 12
Sequence:
MRGRPSLLLVYMGLATCLDTSPHREQNQVLDIFLDAPEAQSFLVGRRRFPRANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYTYNGKGGRGRVDVAGLAVGLTSGILLIVLAGLGAFWYLHYRRRRLRGQESCLQETGLIIPLSPQTPQSPPLPPGLPTYEQALAASGVHDAPPPPYSSLRRPH
Protein: Draxin (Dorsal inhibitory axon guidance protein) (Dorsal repulsive axon guidance protein) (Neucrin) (Q8NBI3)
Organism: Homo sapiens (Human)
Function: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Netrin-1
- Neogenin
- Netrin receptor DCC
- Cell adhesion molecule DSCAM
Sequence:
MAGPAIHTAPMLFLVLLLPLELSLAGALAPGTPARNLPENHIDLPGPALWTPQASHHRRRGPGKKEWGPGLPSQAQDGAVVTATRQASRLPEAEGLLPEQSPAGLLQDKDLLLGLALPYPEKENRPPGWERTRKRSREHKRRRDRLRLHQGRALVRGPSSLMKKAELSEAQVLDAAMEESSTSLAPTMFFLTTFEAAPATEESLILPVTSLRPQQAQPRSDGEVMPTLDMALFDWTDYEDLKPDGWPSAKKKEKHRGKLSSDGNETSPAEGEPCDHHQDCLPGTCCDLREHLCTPHNRGLNNKCFDDCMCVEGLRCYAKFHRNRRVTRRKGRCVEPETANGDQGSFINV
Protein: Phosphate import ATP-binding protein PstB (EC 7.3.2.1) (ABC phosphate transporter) (Phosphate-transporting ATPase) (P0AAH0)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
Subcellular location: Cell inner membrane; Peripheral membrane protein.
Interaction partners:
- Phosphate transport system permease protein PstA
- Phosphate-specific transport system accessory protein PhoU
- Phosphate-binding protein PstS
- Phosphate transport system permease protein PstC
- Phosphate regulon sensor protein PhoR
- Glutathione/L-cysteine transport system ATP-binding/permease protein CydD
- Phosphate regulon transcriptional regulatory protein PhoB
- Putrescine export system ATP-binding protein SapD
- Phosphonates-binding periplasmic protein
- Low-affinity inorganic phosphate transporter PitB
Sequence:
MSMVETAPSKIQVRNLNFYYGKFHALKNINLDIAKNQVTAFIGPSGCGKSTLLRTFNKMFELYPEQRAEGEILLDGDNILTNSQDIALLRAKVGMVFQKPTPFPMSIYDNIAFGVRLFEKLSRADMDERVQWALTKAALWNETKDKLHQSGYSLSGGQQQRLCIARGIAIRPEVLLLDEPCSALDPISTGRIEELITELKQDYTVVIVTHNMQQAARCSDHTAFMYLGELIEFSNTDDLFTKPAKKQTEDYITGRYG
Protein: H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (Dyskerin) (Q5ZJH9)
Organism: Gallus gallus (Chicken)
Function: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:O60832}. Nucleus, Cajal body {ECO:0000250|UniProtKB:P40615}.
Interaction partners:
- H/ACA ribonucleoprotein complex subunit
- Nucleolar protein 58
- SHQ1, H/ACA ribonucleoprotein assembly factor.
- Ribonucloprotein
- Nop domain-containing protein.
- Nuclear assembly factor 1 ribonucleoprotein.
- Telomerase reverse transcriptase
- RNA helicase.
- Pescadillo homolog
- Ribonucloprotein
Sequence:
MADGDGSSVKKRRKKDKRSLPDEDVADIQHTEEFLIKPESRVAQLDTSQWPLLLKNFDKLNVLTTHYTPLPSGANPLKREISDYVRSGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIESEAQLARAIETLTGALFQRPPLIAAVKRQLRVRTIYESKLVEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGILGEMDNMVTMHDVLDAQWQYDNNKDDSYLRRVILPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIELKQEIVVITTKGEAICLAIALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGKPNECTPDSWKKEYVDYRESSKKEAAKVPQAVSEVERAPKRKRESESENEAVSPPPSPATPPPEELSKKEKKKKKKEKKAKEAAESGEEQVEVISESSAKKKKKKKKQKEVEESSE