wanglab/gogpt-training-data huggingface dataset:
Protein: Exosome complex component csl4 (O59821)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Exosome complex component rrp40
- Exosome complex protein C1739.07
- Exosome complex component rrp43
- Exosome complex component rrp46
- Exosome complex component rrp45
- Exosome complex component ski6
- Exosome complex component mtr3
- Exosome complex exonuclease dis3
- Exosome complex component rrp42
- Exosome complex component rrp4
Sequence:
MNLVLPGQVVARGAPNGEGTVKRGDYIISTRTGIFDPEKNSVTYPRKVEETAVLPNVGSIVLARVSRINARQATVNISVVDDVCTKDEFQGVIHVQDIRATEKNKVKVQNSFRPGDIVRALVISLGDGSSYFLTTARNDLGVIFAQSSETGEQMFPVDYQHMQTKSGYTEMRKCAKPILDE
Protein: CMP-sialic acid transporter, putative (Q381D0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MFPLRSVSSSQFNSQANSYSLFHYVLLVLLTVQNATIVILMSYTQQRQSSKDPSNRFNTSHVVMMTEMVKFLMSLAWCAWDVFSTIAPRGSRVLDDSGTDASETPLGHRGSDVMRDVKTLKQDQKLLCYEDSHEDNSNGAKLATNMESAPADLSSDAQSIEVEINREGFCGLFLLQLLHRSAVPTAVPAIIYAFQNYVMFVALANMEPTLFQVTYQTKILGTALLLWIFLGRTFSSQQWMALFLLMAGVVLAQLGSKHSSRKPEEKTNSVEISGSYVVGVVATTMAVLCSSAGAVMSEWLFKSKDASLSSHTSTKNVHLSAYSVVCYIVAQLLAGSGSNTQGQAQVNATPDDVNAGTSFFQEYFRGFDSLVWLMIFVQAVGGLLVALVIKHTDNIMKAFAAGCSIVLSGILSLLIYSFVPGILFVIGSMLCIVALIIYSRG
Protein: Probable DNA mismatch repair protein Msh6 (Q9VUM0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in post-replicative DNA-mismatch repair.
Interaction partners:
- Mlh1, isoform A
- DNA mismatch repair protein spellchecker 1
- Pms2
- Exonuclease 1
- Proliferating cell nuclear antigen
- DNA polymerase delta catalytic subunit
- Flap endonuclease 1
- DNA polymerase epsilon catalytic subunit 1
- Proliferating cell nuclear antigen 2
- RecQ-like DNA helicase Blm
Sequence:
MSKKLNTSVGGTPTNTLLNYFSKSPAFDKKKLTPSVKTDPDASKSEKENLQNQQPKVKDGKKEASKPAAKRKLPISDDEPASGQRKRKRIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLSNLRIIGEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQLEEGYHPCANASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLANLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTKKEKINALKDLLKQLKMCQV
Protein: Sterile alpha motif domain containing 4A (G3V2R1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MILTPIKAYSSPSTTPEARRREPQAPRQPSLMGPESQSPDCKDGAAATGATATPSAGASGGLQPHQLSSCDGELAVAPLPEGDLPGQFTRVMGKVCTQLLVSRPDEENISSYLQLIDKCLIHEAFTETQKKRLLSWKQQVQKLFRSFPRKTLLDISGYRQQRNRGFGQSNSLPTAGSVGGGMGRRNPRQYQIPSRNVPSARLGLLGTSGFVSSNQRNTTATPTIMKQGRQNLWFANPGGSNSMPSRTHSSVQRTRSLPVHTSPQNMLMFQQPGSQVHSGLCLTDLRGWLSLSGAPSMPALTVPKSSQGEFQLPVTEPDINNRLESLCLSMTEHALGDGVDRTSTI
Protein: Colipase (P17084)
Organism: Rattus norvegicus (Rat)
Function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Pancreatic triacylglycerol lipase
- Inactive pancreatic lipase-related protein 1
- Pancreatic lipase-related protein 2
- Bile salt-activated lipase
- Chymotrypsinogen B
- Chymotrypsin-like elastase family member 2A
- Carboxypeptidase A1
- Syncollin
- Zymogen granule membrane protein 16
- Proteasome 20S subunit beta 10
Sequence:
MKVLVVLLVTLVAVAYAAPGPRGLFINLEDGEICVNSMQCKSRCCQHDTILGIARCTHKAMENSECSPKTLYGIYYRCPCERGLTCEGDRSIIGAITNTNYGVCLDSTRSKQ
Protein: CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)] (Q9Z2V2)
Organism: Rattus norvegicus (Rat)
Function: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P29965}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P29965}. Cell surface {ECO:0000250|UniProtKB:P29965}.; SUBCELLULAR LOCATION: [CD40 ligand, soluble form]: Secreted {ECO:0000250|UniProtKB:P29965}. Note=Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000250|UniProtKB:P29965}.
Interaction partners:
- Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a.
- Inducible T-cell costimulator
- T-lymphocyte activation antigen CD80
- T-lymphocyte activation antigen CD86
- Tumor necrosis factor
- ICOS ligand
- T-cell surface glycoprotein CD4
- CD70 antigen
- TNF superfamily member 13b
- Tumor necrosis factor ligand superfamily member 4
Sequence:
MIETYSQPSPRSVATGLPASMKIFMYLLTVFLITQMIGSVPFAVYLHRRLDKVEEEASLHEDFVFVKKLKRCNKGEGSLSLLNCEEMRRQFEDLVKDISLNKEEKKEKSFEMQRGDEDPQIAAHVVSEANSNAASVLQWAKKGYYTMKSNLVVLENGRQLTVKREGLYYVYTQVTFCSNREPLSQRPFIVSLWLKPSSGSERILLRAANTHSSSKLCEQQSIHLGGVFELQAGASVFVNVTEASQVIHGIGFSSIGLLKL
Protein: Roundabout homolog 3 isoform X3 (Roundabout, axon guidance receptor, homolog 3 (Drosophila)) (A0A2R8QRK0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Slit homolog 1b
- Protein kinase C-binding protein NELL2a
- Slit homolog 2
- NEL-like protein 2
- Netrin-1
- Netrin 2.
- Slit homolog 1a
- Netrin-1
Sequence:
MLRYLIKTLLQMNLFTDTIRDATNGTDLFFNISSIPSFNSSLLDWANFTGLNGSRPRLEDAAPRIVEHPSDLIVSKGEPATLNCKAEGRPTPMVEWYKDGERVETDREDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGVYVCVARNYLGEAVSRNASLEVAILRDDFRQTPSDVVVAAGEPAVMECIPPRGHPEPTISWKRNNVKVNDKDERITIRGGKLMISNTRKSDAGMYVCVGTNMVGEKDSDPAELVVFERPMFVRRPVNQVVLADDTVDFQCEVQGDPAPTIRWKKEEGELPRGRFEIRADNSLRLTQVKAEDEGSYTCLSENSVGKAEASGSLQVHVPPQIVVRPRDQISAQGRTVTFLCGTKGNPPPAVFWQKEGSQVLLFPSQPPSQSGRFSVSLSGELTITDVHSEDSGYYICQAISVAGSILTKALLEVESTPSDRIPPIIRQGPANQTLAPGTTAQLQCHVMGNPLPSIQWERDGQRILGIDERISLMENGTLQITALQETDSGAYTCVASSLSGETSWSGVLTVKESGGLSASPVSEPYQLPGPPQKPVVTDVTRNSVTLTWQPNAHEGGAAVTSYIIEAFSQSAGSTWQTVADFVKLEKHTVTGLSPNTIYLFIVRAVNAYGLSDPSPISEPVRTQDVSPTGQGVDHRQVQRELGEMSVQLHEPVLLTASSVKISWNVDRQSQYIQGYRLLYRPVGGSWSQQEVKGATERSAVIANLLKGTEYEIKIRPYFNEFQGLDSRSQTLRTPEEVPSAPPRAVNVATVKLSNSSSISVSWQPPPTDMQNGVIQEYKVWCLGNDSQTRYNINQTVDGSVLSTVLKGLLPGVLYQVEVAAVTSAGVGKHSQPVSVLIKLPAEQPTVTGGGSESEENVSLAEQITDVVKQPAFIAGIGGACWVILMGFSVWIYCRRKKRKELSHYTASFAYTPAVGFPHGESSGLNGRPGMLGANMGNYPWLADSWPTTNLVHNGKDSVNCCTSKHETPERYYNEAGISNYLNQNEKYSADSNEGPIYSTIDPTSEDLRSFTAQYSQHTTPYASTPIMPFTNQAPCSPEQDGSHWMTQPGTSNAQYAQPDRSKTENVKQPKQKLMGKPVKTPSLNWMDALPPPPISGDLEQCDEEDDNELIQDMGSDEEEWCPPLPERSYLMDGMVEDGPVPPPRGEASSPTTSYSHQSTATLTPSPRDDGHFHDIPRLHQLEQPHMTRRLPCGPVPVPRAPSPPLTQSNPNLSANQECPDNTVPHRSAHKRDLSQGAAQSVENISNTTPGRARPSADHTSSGQKSKVKKKASKSAQYRRDILQGDLPPPPEPPPEDQDNCAHVGGFECGQTSLERAGSSNSSMERREQSTPNRKNSAHRRIDADDDLIPYNKPNFLSRGQMSSNCSTTGSSSSRGSTGSRGQGTGRKRNDEMR
Protein: KH domain-containing protein 3 (ES cell-associated transcript 1 protein) (KHDC3-like protein) (Q587J8)
Organism: Homo sapiens (Human)
Function: As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation. Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific (By similarity). Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for maintenance of euploidy during cleavage-stage embryogenesis (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (By similarity). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity). Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus (By similarity). May regulate normal development of learning, memory and anxiety (By similarity). Capable of binding RNA (By similarity).
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:25542835}. Nucleus {ECO:0000269|PubMed:25542835, ECO:0000269|PubMed:31609975}. Mitochondrion {ECO:0000250|UniProtKB:Q9CWU5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9CWU5}. Chromosome {ECO:0000269|PubMed:31609975}. Note=Localized to centrosomes during interphase and mitosis (By similarity). Localizes to sites of DNA double-strand break repair (PubMed:31609975). {ECO:0000250|UniProtKB:Q9CWU5, ECO:0000269|PubMed:31609975}.
Interaction partners:
- NACHT, LRR and PYD domains-containing protein 5
- Transducin-like enhancer protein 6
- Oocyte-expressed protein homolog
- KH homology domain-containing protein 1
- NACHT, LRR and PYD domains-containing protein 7
- Inactive protein-arginine deiminase type-6
- NACHT, LRR and PYD domains-containing protein 2
- Ubiquitin-like protein FUBI
Sequence:
MDAPRRFPTLVQLMQPKAMPVEVLGHLPKRFSWFHSEFLKNPKVVRLEVWLVEKIFGRGGERIPHVQGMSQILIHVNRLDPNGEAEILVFGRPSYQEDTIKMIMNLADYHRQLQAKGSGKALAQDVATQKAETQRSSIEVREAGTQRSVEVREAGTQRSVEVQEVGTQGSPVEVQEAGTQQSLQAANKSGTQRSPEAASKAVTQRFREDARDPVTRL
Protein: Homothallic switching endonuclease (Ho endonuclease) (P09932)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Initiation of mating type interconversion. This protein is a site-specific endonuclease that cleaves a site in the mat locus on chromosome III. The double-strand break is followed by a unidirectional gene conversion event that replaces the information at the mat locus by information copied from either of the two homologous loci (HMR and HML) that reside at the extremity of the chromosome III. Endonuclease expression takes place in late G1 just before cells enter S phase.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- V-type proton ATPase subunit B
- V-type proton ATPase subunit E
- V-type proton ATPase subunit D
- V-type proton ATPase subunit d
- V-type proton ATPase subunit F
- V-type proton ATPase subunit c
- V-type proton ATPase subunit c''
- V-type proton ATPase subunit H
- V-type proton ATPase subunit a, Golgi isoform
- V-type proton ATPase subunit a, vacuolar isoform
Sequence:
MLSENTTILMANGEIKDIANVTANSYVMCADGSAARVINVTQGYQKIYNIQQKTKHRAFEGEPGRLDPRRRTVYQRLALQCTAGHKLSVRVPTKPLLEKSGRNATKYKVRWRNLQQCQTLDGRIIIIPKNHHKTFPMTVEGEFAAKRFIEEMERSKGEYFNFDIEVRDLDYLDAQLRISSCIRFGPVLAGNGVLSKFLTGRSDLVTPAVKSMAWMLGLWLGDSTTKEPEISVDSLDPKLMESLRENAKIWGLYLTVCDDHVPLRAKHVRLHYGDGPDENRKTRNLRKNNPFWKAVTILKFKRDLDGEKQIPEFMYGEHIEVREAFLAGLIDSDGYVVKKGEGPESYKIAIQTVYSSIMDGIVHISRSLGMSATVTTRSAREEIIEGRKVQCQFTYDCNVAGGTTSQNVLSYCRSGHKTREVPPIIKREPVYFSFTDDFQGESTVYGLTIEGHKNFLLGNKIEVKSCRGCCVGEQLKISQKKNLKHCVACPRKGIKYFYKDWSGKNRVCARCYGRYKFSGHHCINCKYVPEAREVKKAKDKGEKLGITPEGLPVKGPECIKCGGILQFDAVRGPHKSCGNNAGARIC
Protein: GATA transcription factor 6 (Q9SD38)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Bifunctional bis
- High mobility group B protein 3
Sequence:
MESVELTLKNSNMKDKTLTGGAQNGDDFSVDDLLDFSKEEEDDDVLVEDEAELKVQRKRGVSDENTLHRSNDFSTADFHTSGLSVPMDDIAELEWLSNFVDDSSFTPYSAPTNKPVWLTGNRRHLVQPVKEETCFKSQHPAVKTRPKRARTGVRVWSHGSQSLTDSSSSSTTSSSSSPRPSSPLWLASGQFLDEPMTKTQKKKKVWKNAGQTQTQTQTQTRQCGHCGVQKTPQWRAGPLGAKTLCNACGVRYKSGRLLPEYRPACSPTFSSELHSNHHSKVIEMRRKKETSDGAEETGLNQPVQTVQVVSSF
Protein: 5-hydroxytryptamine receptor 2A (5-HT receptor 2A) (Serotonin receptor 2A) (P28285)
Organism: Drosophila melanogaster (Fruit fly)
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which inhibit adenylate cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Sodium-dependent serotonin transporter
- Tryptophan 5-hydroxylase 2
- G protein alpha i subunit subunit alpha 65A)
- Muscarinic acetylcholine Receptor, B-type, isoform A
- G protein beta subunit 5
- Muscarinic acetylcholine receptor DM1
- G protein alpha s subunit subunit alpha)
Sequence:
MAHETSFNDALDYIYIANSMNDRAFLIAEPHPEQPNVDGQDQDDAELEELDDMAVTDDGQLEDTNNNNNSKRYYSSGKRRADFIGSLALKPPPTDVNTTTTTAGSPLATAALAAAAASASVAAAAARITAKAAHRALTTKQDATSSPASSPALQLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSATTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGKL
Protein: Bestrophin 2 (FI02024p) (Q9VRW4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKKIRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLMRRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVWATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAALLGRQMLPNVLDRSGREDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDAMYANIMPGGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMRSQSTAYSSGGMPFNRNRLNSVYSSPESGLPLTILQQQQLQQAHQQQQAGSQPSKSSLYGKFVHRKSLRAQRQLIKQNSKLNGLNVNVAKTRPRIPTPEVAKDGNTNPATSSVLMAPQQLSTTSAPPGMYPSSYAPDTLLHQESGQVLGTLLLSPIKEMDSSSSNNTLIPGHPATAALAASMKEGFTPSSIPAATNITTLSFPFSVTSTGGETMPTGTLSILPISANAQLPTITTTASGYDPNDVITTIPVSLSIQRSPSALSIVELTGADVQDGYSNSGSSNGNGGITTTALLSVKPLNGNQNISRNNSFNLSLNLQDPQQRSSMRSAGPTGTVDNSGTMPIPQRSGGLETGEVGGSSAPSTLAKHKPEQKTGEVYV
Protein: Missing-in-metastasis, isoform L (A0A0B4KEE8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDLSLERDSSALGSLFQQIINDMKNTSPLWEDFVAKAGKLHTCLRAAIQAIAAYLDAFQKIADAATNSRGASKEIGTALTRVCLRHKAVETRLKTFTSTIMDCLVQPLQERIEDWKRTVATIDKDHAKEYKRCRSELKKRSSDTLRLQKKARKGQTDGLQSLMDSHMQDVTLRRAELEEVEKKSLRAAMVEERLRYCSFVHMLQPVVHEECEVMSELGHLQEAMQSIALVTKEPSVLPQASEELIHDAKASINLYPESPGGGSGSQGGGCSNSLGSRKSSVCSISSMNSSGSSNSPGHHHYPRSLSQFVTPAIRLKPGESSDSGFCSSPALTTQTSNATNQTANVSTWPPHSQDGVDTLPPTADRPHTISTAYEKGHQRPPLTVYTFQNPETIHESGSCLNNGTAAPNGQPLSGQATPATQKSPAASLSRPPLPVRCSSLERPLSAQSNHRQGSGNNLLQRQCPSPIPAHITKGTPSGSSLGPGSGLGFVYQVSSPTPPSSEVLKITEQAAAGQDQGPANSVADETDERSRASVLQKASMFEKAAAAAAVSPPAPMQIASGSPASGGGTRRSEAEQQEMDKSFEDSIQALNNLIGELDSFQREIDEGKVKPPSNIISGSTTSSNNNNTTTSSISSSDNNNLPATSNIEPCAISNQTNSSGCGTDISDTTSDELAGDDMDVRRRDRDRDRDLLGASDSELSRCYVSETSSLTGGLTAGGYENPTFAHFAANANREDAVSLASDSVCLGQPRHAYVDTCSDSGSAVVVIYDHQIPNTPDIEFVKQNSEIVVLRTKDPQPHALQLHEMRELQQLPANLAGSPDSSPDSAGGQAPPTATVAPAKQRLSSFRATSEQQLQLLGRGSPQRGKTPSEQAVQSRPQDQHFPQTQQQDIDGSSPPVELARRQLPPKPTSLSIFNGPVPTAGDRPVVPRKSDFKADLDAKIRRQKQKVKQQLQQQQQQQQQEQQETQQQQQAPQEQQHSPQSPQTRNCNVTNQQAANITASASAFATATASTDPYPNPNHRMPNQNQTATSNHTQCKTPTMALSPSSPRGHLPLSSSSLSSLPLPATTSSPSNARPSMLPASDRPPAHPYVCSNAPANPHHANSISNANAHLKPCITPRPASLSGGAAGGGSTRIGRRSSINQSKPPPPVRRSSSVTPSPNASVGLQQQPQHATLSQQNHQLSSSSEHLPPPPPFMLDAMPQIPSSALKVSETVRALAAMRHQPASPVSLRRMQQQQQQQLQQQQQQQSAHNSPLKEDLTVYYDSYLDLHAYAQALASGQQPGGQQMANQQRFTLQQQHQHLHQPQQPPVYQVDATFRTSSPAAGGGGGGGIYAQPKLVNSMSSFRTSSPSPNGHAHPLPPTQPKANPNLIAQLNARLSGKQQQHQQQQHIEGIYGNQQAPGGESIYMRSGLSMSQPQQQQHFDATSGSASSHYQPPQPPNAAVANSKDMAIYSSSFTKNPAAAQSPNMRQAHSHQHHQPPQQQHYTCPPPLEDPPPPPIYAAGASATMPKKMARPPTGQNATHSSAYAAASSTATLPKNMMQQQQRLQHQQQYQQPAGMGIGNGNGHLGQRPQLPLPQQKLRAAQQQHLAEQQHQQQQEQQQHHQQHQQHQQRQPPIPSRHSSVQQKIFVSTNPFIQTTAVKFHSPSASPTCGSPVTGSLASIYATTSRGGHHHQQQQAQQQQHYYRDAAGGNSNGGAAYYNHNAHAHSQAHHPNYATSTNIEKTGSIRAKTKAEFLENLNAKLAKQGMSGRAFAVRNLINSKALMYQNPQKLSRPSAQYRRPPTYPNTSTTTNATCEDQC
Protein: Protocadherin gamma A7 (Q91XY1)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MAPGQRGWGSHYRGFVLLSILLGMRWEAWAGQILYSVSEETDKGSFVGNITKDLGLQPRELAERGVRIITKGKTQLFSLNPRSGSLVTAGRIDREELCAQSPRCLVSFNILIEDKMNLYPIEVEIMDVNDNAPRFLTEEINIKIMENAAPGVRFPLKEATDSDVGKNSLQRYQLSPNHHFSLVVQSGDDGTKYPELVLEKALDREEEGLHHLVLTAYDGGDPLRSGTASIRVTVVDVNDHTPVFSLPLYQATVPENVPVGTRLLTVNPIDLDEGIYGEVTYSFWKITPELLQIFHLSSLTGELSTLKGLDYEQSSFYELEVQAQDGAGSLTKAKVLITVLDVNDNAPEVTVTSVSSPVPEDTPPGTVIALFYLQDKDSGKNGEVTCSLPENLPFKLERSIDNYYRLVTARNLDREKMSVYNITLKATDGGIPPLSTETRMSIHVSDTNDNPPTFSDSSYSIYVPENNPRGASIFSVTAQDPDSDKNAQVTYALAEDTIQGVPVSSYVSINSDTGILYALGSFDYEQFRDLQLRVTARDSGDPPLSSNVSLKLFVLDKNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGPNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQNLVVVVQDHGQPPLSATVTLTVAVANSIPDVLADLGSIRTPSEPDDSDITLYLVVAVATVSCVFLVFVTVLLALRLWRWHKSHMLQASSGGGLEDVPASHFVGLDGVQAFLQTYSHEVSLTADSRKSHIIFPQPNYVDTLISQDSCEKSDSLLTSIDFQECKGEAPSSQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Protein: 2-pyrone-4,6-dicarboxylate hydrolase (Q0KJL5)
Organism: Novosphingobium sp. (strain KA1) (Sphingomonas sp. (strain KA1))
Interaction partners:
Sequence:
MSNGRIVSWHTSPSKPIYVPPDGAIDAHCHVFGPMARFPFSSKAKYLPEDAGPDMLFALRDHLGFDRNVIVQASCHGTDNAATLDAIAKSNGKARGVAVVDPAIDDAELQMLHDGGIRGIRFNFLKRLVDDAPKDRFLEVARRLPQGWHVVIYFEADILEELRPFMDAIPVPLVIDHMGRPDVTQGSDGPDMKAFRRLLDSRDDIWFKATCPDRLDPNGDPWDMFAESVAPLVADYPTRCLWGTDWPHPNMQDAVPDDGHLVDMIPRIAPTQELQRLLLVTNPKALYWSEER
Protein: Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-) (Q9NUQ7)
Organism: Homo sapiens (Human)
Function: Thiol-dependent isopeptidase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:35926457}. Cytoplasm {ECO:0000250|UniProtKB:Q99K23}. Nucleus {ECO:0000250|UniProtKB:Q99K23}.
Interaction partners:
- Ubiquitin-fold modifier 1
- DDRGK domain-containing protein 1
- Ubiquitin-like modifier-activating enzyme 5
- E3 UFM1-protein ligase 1
- Ubiquitin-fold modifier-conjugating enzyme 1
- CDK5 regulatory subunit-associated protein 3
- Protein odr-4 homolog
Sequence:
MVISESMDILFRIRGGLDLAFQLATPNEIFLKKALKHVLSDLSTKLSSNALVFRICHSSVYIWPSSDINTIPGELTDASACKNILRFIQFEPEEDIKRKFMRKKDKKLSDMHQIVNIDLMLEMSTSLAAVTPIIERESGGHHYVNMTLPVDAVISVAPEETWGKVRKLLVDAIHNQLTDMEKCILKYMKGTSIVVPEPLHFLLPGKKNLVTISYPSGIPDGQLQAYRKELHDLFNLPHDRPYFKRSNAYHFPDEPYKDGYIRNPHTYLNPPNMETGMIYVVQGIYGYHHYMQDRIDDNGWGCAYRSLQTICSWFKHQGYTERSIPTHREIQQALVDAGDKPATFVGSRQWIGSIEVQLVLNQLIGITSKILFVSQGSEIASQGRELANHFQSEGTPVMIGGGVLAHTILGVAWNEITGQIKFLILDPHYTGAEDLQVILEKGWCGWKGPDFWNKDAYYNLCLPQRPNMI
Protein: DiSHevelled related (B7WN58)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAESPPPVDSSLNAPNVGSPTTMMERLRLRDQTEENGKEDDFDNKSVSSAQYSQTSEATTAVKQQPFLHTMTKVYCHIDDETDPYMLEVHVPPDLITLGDLKRVLMRTNFKYYRKALDPDSGYEVKAEIRDDSQRLTPSPNNLFELFLLTIEGSTHSDGSSGKMRKYPSVPGPAPSNRNGPPMNYQHAAYQFDNSMMSTDSESMISAAIPGYLKSAAYNRRFPQHYLGHRRHLEESTIGSESDARVFSDDDDRGSTTTDFTSVSRQHEKMAKKKKNKRNFRKPSRASSFSSITESSMSLDVITVNLNMDTVNFLGISIVGQTSNCGDNGIYVANIMKGGAVALDGRIEAGDMILQVNETSFENFTNDQAVDVLREAVSRRGPIKLTVAKSFENGQSCFTIPRNSREEPVRPIDTQAWIQHTNAMRGMPSIVEESAPTPIPGEWPHGRPPSSSTVTSNGSNGQNTVVGGGAHIILDIHTDKKKVVEIMAMPGSGLDIKNRTWLKIPIPMSFLGSDLVEWLLDHVEGLRERKTARNFAADLLKLKYIAHVVNKVTFTEQCYYVLGDECSDYARFRNEDGGPKYQWTIGMNGMSAGNGSSVMLPPPHLPGGMAGPPGAFKGMAPSMVSDGESRMYVMHI
Protein: PILR alpha-associated neural protein (PILR-associating neural protein) (Paired immunoglobin-like type 2 receptor-associating neural protein) (Q5U2P6)
Organism: Rattus norvegicus (Rat)
Function: Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MWPAQLLSQLLPLWPLLLLPLSLPAQGSSHRSPPAPARPPCVRGGPSAPRHVCVWERAPPPSRSPRVPRSRRQVLPGTAPPATPSGFEEGPPSSQYPWAIVWGPTVSREDGGDPNSVNPGFLPLDYGFAAPHGLATPHPNSDSMRDDGDGLILGETPATLRPFLFGGRGEGVDPQLYVTITISIIIVLVATGIIFKFCWDRSQKRRRPSGQQGALRQEESQQPLTDLSPAGVTVLGAFGDSPTPTPDHEEPRGGPRPGMPQPKGAPAFQLNR