wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein YOR385W (Q08909)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Uncharacterized protein YOR381W-A
- Uncharacterized protein YMR320W
- Ferric reductase transmembrane component 5
- Protein DIA1
- Deoxyribodipyrimidine photo-lyase, mitochondrial
- Calcium/calmodulin-dependent protein kinase II
Sequence:
MRGFSGQPLSDDDNYRIEKTQRNTIPERLHFSRERNMPIASIFGTRGYFVFSSEQSYDKFKQTNFNISTLDADGVGVPLFHIVQSYNVIGKITRSSPDFYIYKYVLQGVQDPPLYSDCKVICQDKVFRLCKILYCEIYAHQGFFETKYDFFYPSKTQPVKKYQIIKQSNMRDLYSTLDGMRFRWHVKFYSDHFRLMFLDEDRLNYSNSNQKERQKPDQGKSKAPDFVIGHYTRTFSDILPRSTSKCSNLIIGEHSKPDSLGITTVPDLTQEFACQGALIHYLLHIERERK
Protein: Gap junction beta-2 protein (Connexin-26) (Cx26) (P29033)
Organism: Homo sapiens (Human)
Function: Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16849369, ECO:0000269|PubMed:17551008, ECO:0000269|PubMed:19340074, ECO:0000269|PubMed:19384972, ECO:0000269|PubMed:21094651, ECO:0000269|PubMed:26753910}; Multi-pass membrane protein {ECO:0000269|PubMed:17551008, ECO:0000269|PubMed:19340074, ECO:0000269|PubMed:21094651, ECO:0000269|PubMed:26753910}. Cell junction, gap junction {ECO:0000269|PubMed:16849369, ECO:0000269|PubMed:17551008, ECO:0000269|PubMed:19340074, ECO:0000269|PubMed:19384972, ECO:0000269|PubMed:21094651, ECO:0000269|PubMed:26753910}. Note=Colocalizes with GJB4 at gap junction plaques in the cochlea. {ECO:0000250|UniProtKB:Q00977}.
Interaction partners:
- Gap junction beta-1 protein
- Gap junction beta-6 protein
- Gap junction alpha-5 protein
- Gap junction alpha-1 protein
- Pendrin
- Gap junction alpha-3 protein
- Gap junction alpha-8 protein
- Homeobox protein NANOG
- Unconventional myosin-XV
- Gap junction delta-3 protein
Sequence:
MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV
Protein: RNA polymerase II transcription factor B subunit 3 (RNA polymerase II transcription factor B 38 kDa subunit) (RNA polymerase II transcription factor B p38 subunit) (Q03290)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- General transcription and DNA repair factor IIH subunit TFB6
- General transcription and DNA repair factor IIH helicase subunit XPD/RAD3
- Cyclin CCL1
- General transcription and DNA repair factor IIH subunit TFB4
- General transcription and DNA repair factor IIH subunit TFB2
- General transcription and DNA repair factor IIH subunit SSL1
- Serine/threonine-protein kinase KIN28
- Transcription initiation factor IIE subunit alpha
- Transcription initiation factor IIE subunit beta
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
Sequence:
MLMDEYEENKDMCPICKTDRYLSPDVKFLVNPECYHRICESCVDRIFSLGPAQCPYKGCDKILRKNKFKTQIFDDVEVEKEVDIRKRVFNVFNKTIDDFNGDLVEYNKYLEEVEDIIYKLDHGIDVAKTEEKLRTYEELNKQLIMNNLERSRTEIESFEQRQKFEKEMKLKKRLLERQIEEEERMNKEWTKKEIVNRLSTTTQDINETIEGVKNTVKLKKSSARRKLEELNRVLKNNPYFNSNVNVQNSRLKDAVPFTPFNGDREAHPRFTLKGSVYNDPFIKDLEHRKEFIASGFNTNYAYERVLTEAFMGLGCVISEEL
Protein: Meiosis 1 arrest protein (Meiosis 1-arresting protein) (Meiosis 1-associated protein) (Spermatogenesis-associated protein 37) (Q9Z0E1)
Organism: Mus musculus (Mouse)
Function: Required for meiosis I progression during spermatogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23269666}.
Interaction partners:
Sequence:
MNRRKTTSRGTSAAMKISHQPPRLLIVNIAVPSWVDICPNLCEALQNFFSIACSLMGPSRMSLFSLYTVQNQHECVLPFVQVRGNFIRLQACISELRMLQVEGCHRPPHALLPLAIEDGLQQFKQYSSHMASSAAQPWTSLEITVLTSRPGKEVVKELEEGLKDINLLSVRRLQVAEVTKGIQERSDSPSPTEEPSNDESSILEADIVLETLDNDVVSMEVFFKAWLHNSETDQENIHLLLTPQSLPPPSRAKDHPICLKCDLQERFLSPSLLPGTADGVSRIDDPKGDISTLYQMASLASASPYKLQVVKALKSSGICESLTYGLPFILRPTSCWQLDWDELETNQQHFHALCHCLLKRDWLLLARGEPLIHKHNQSLPACSFYVITPSHSLTLLVKLVATRELMLPGFFPLLSEDPPEDSLKIIESTLDSLDLGLTYNPLHVGSHLYSHLSSAHAKPQGRLYTSCASRGLRKGGQLQTNRVRAAVVPLPVAPAPRRALKMTAASKASSAAFLPSDSEEGEEERPSHT
Protein: T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (Q32L40)
Organism: Bos taurus (Bovine)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P17987}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P17987}.
Interaction partners:
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit epsilon
- Uncharacterized protein
- T-complex protein 1 subunit zeta-2
- Chaperonin containing TCP1 subunit 8 like 2
Sequence:
MEGPLSVFGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYISENLIINTDELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIRGQPRYPVNSINVLKAHGRSQMESMLINGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELILIKNTKARTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGGYEDAVHSGALDA
Protein: EG:100G10.1 protein (LD47334p) (O76861)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Cell division cycle 5, isoform A
- Pleiotropic regulator 1
- Protein CWC15 homolog
- Splicing factor 3A subunit 2
- LD41978p
- LD40504p
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor SPF27
- Heat shock 70 kDa protein cognate 4
- Ubiquitin-like protein 5
Sequence:
MGRRSINTTKSGKYMNPTDQARKEARKKELKKNKKQRQMVRAAVLKNKDPSQILEEMEKIDEMEYNVLQPSPLNEKVLRDKRKKLKETFDRVMRLYHNDEPEHWADLKRKEVEYEKKRLKKQQYYESVKHAQSVQIDEIPLPAPVSAVSGGSTETTGGSVVAGFGASVVIRLPPPPMTMALPPYAPGAPPGVSRNSDLASEAQVEKSKENEQKDWLGVPPGPPPDLFAFSELNSDAEGNTDYDGEGEEEEPEPLKKGKDKEKDKNSEATEPNNQNIDDFMKEMEHVHKRKHRKLAAKEDEADKKREEDDGKDIDKIEERTSDSDKRTASSTDDEDDDDQDEDENMPEVPTKPASVKSSTATPAPAPPTAPTLPTIPLPPASSVPAPPQLPHLPPIPNLGPPGIMYRPPPMRPPHPGSGFGIRMPPGPPPGPRAPHGLGPIPRMGIRMPPGPPPGLPPRLAHHNKQGGGAGAPKESAKGVATITAKPQIRNLSADVTRFVPSTLRVKREDQRRTARPRHAANDGHHAHSEAHSKPPTKDDAYLQFMNEMQGLL
Protein: Adenylyl-sulfate kinase 3 (EC 2.7.1.25) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase 3) (Adenosine-5'-phosphosulfate kinase 3) (APS kinase 3) (Q9SRW7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the synthesis of activated sulfate for the sulfation of secondary metabolites, including the glucosinolates. Essential for plant reproduction and viability.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:19304933}.
Interaction partners:
- ATP sulfurylase 2
- ATP sulfurylase 1, chloroplastic
- ATP sulfurylase 4, chloroplastic
- ATP-sulfurylase 3, chloroplastic
- 5'-adenylylsulfate reductase 1, chloroplastic
- 5'-adenylylsulfate reductase 2, chloroplastic
- 5'-adenylylsulfate reductase 3, chloroplastic
- Assimilatory sulfite reductase
- FAD synthase
- Adenylyl-sulfate kinase 4, chloroplastic
Sequence:
MSTVGNSTNIFWQESPIGKTERQKLLNQKGCVVWITGLSGSGKSTLACSLSRELNNRGKLSYILDGDNLRHGLNKDLGFKAEDRVENIRRVGEVAKLFADAGLICIASLISPYRKDRDACREMIQNSSFIEVFMNMSLQLCEARDPKGLYKLARAGKIKGFTGIDDPYESPLNCEIELKEKEGECPSPVAMAEEVISYLEDKGFLQNE
Protein: RNA helicase (EC 3.6.4.13) (B7WN80)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDQNEENKGSNGWGISRGGMFGGPKASNAPPPQTSFGSTSGTRVGGSFGGQAGVDGRGAPLGSAEELIGGVPIMPGQSQPMRGGFQGAYRGGRGSGGGQMDFGAPGQGQSMGRGRGQQNPAFVPRPRDTPPQYGGHQAAQQFVKPDSKYKFTKPATEEAHEQVPVPADIALLNKFIQKEVKMMKDVVVDVQRQDPKSPLYSISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEPPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTLELAKQIGEVVEKMGKFIDNLKIHYAIKGGNMAAMRGRKLTEQIVIGTPGITRDYLQKYKCIDPSKIRCLVLDEADVMIYHQGFTDISTTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVVMLKREEQALPNIKQFYVQCACRDSKYAAIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVINYDLPIKYTDEGTPMVVDGFTQPDCETYLHRIGRTGRFGKTGIAINLIDSEDSMNMINVLENHFQMKIARMDPSNLVELEAIEMA
Protein: Cellular repressor of E1A-stimulated genes, isoform A (Cellular repressor of E1A-stimulated genes, isoform B) (Cellular repressor of E1A-stimulated genes, isoform D) (GH28782p) (Q9VEK7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MKTFHSLLFALILALVSLDPSSGYSRRKDERIIREYKREQELNHAKIARDLVHRANWAAVGSLSTNERVKGYPMVNIISIDDSDANNRSTGRIRFLLTDLDFTGPDWQKDNKVTLLFSDEQTLRCKEGGKDPMEPTCARSMISGQVKKMDPSDKSYQPSLDAYVRRHPAAINWVKAHNFYLCELEISNIFVLDFYGGPHKVSASDYYAVSN
Protein: Oligopeptide transport system permease protein OppC (P9WFZ9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:38548954}; Multi-pass membrane protein {ECO:0000269|PubMed:38548954}.
Interaction partners:
- Oligopeptide transport ATP-binding protein OppD
- Oligopeptide transport system permease protein OppB
- Probable dipeptide-transport ATP-binding protein ABC transporter DppD
- Oligopeptide-binding protein OppA
- Probable dipeptide-transport integral membrane protein ABC transporter DppB
- Uncharacterized lipoprotein Rv2585c
- Phosphate-specific transport system accessory protein PhoU homolog 1
- Probable methanol dehydrogenase transcriptional regulatory protein MoxR2
- Probable periplasmic dipeptide-binding lipoprotein DppA
- Uncharacterized response regulatory protein Rv3143
Sequence:
MTEFASRRTLVVRRFLRNRAAVASLAALLLLFVSAYALPPLLPYSYDDLDFNALLQPPGTKHWLGTNALGQDLLAQTLRGMQKSMLIGVCVAVISTGIAATVGAISGYFGGWRDRTLMWVVDLLLVVPSFILIAIVTPRTKNSANIMFLVLLLAGFGWMISSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVAAAILAETGLSFLGFGIQPPDVSLGTLIADGTASATAFPWVFLFPASILVLILVCANLTGDGLRDALDPASRSLRRGVR
Protein: Sulfate transporter (Q9U6Q2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MGAATAWDPRDQGVYTHCSGKKVKPTVSTLDCTRSWLQDCQRRTFNRKTLHKRLPILGWLPKYNSQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSCKDVPMGPSAIVALLTYQAAQGSWQKSVLLCLLSGIVELLMGLFGLGFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLGITAKGNTFVEIWTQVFHNIEHTRAGDTVLGLTCIVILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIMGYMLHTEEHGAPFRVVGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFANGKPVDASQELIAIGTANIFNSFVQXFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMTALLFLTPYFYFIPRPTLAAIIISAVVFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAARPKLTTELLTTQSGVEYLMITPDRCLIFPSVDYVRNLVNKQSIRQNVPVVIDASHVYGADFTTATVIDSLISDFNQRGQLLFFYNLKPSICSIFEHVSAAQFVVYYQEQQLDELLKERNYVQKRLETA
Protein: Protein ultraspiracle (Chorion factor 1) (Nuclear receptor subfamily 2 group B member 4) (XR2C) (P20153)
Organism: Drosophila melanogaster (Fruit fly)
Function: Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene.
Subcellular location: Nucleus.
Interaction partners:
- Ecdysone receptor
- Taiman, isoform G
- Smrter, isoform G
- Nuclear hormone receptor HR96
- Ecdysone-induced protein 75B, isoform B
- Mediator of RNA polymerase II transcription subunit 1
- Probable nuclear hormone receptor HR38
- HL01030p
- Protein ecdysoneless
- COP9 signalosome complex subunit 2
Sequence:
MDNCDQDASFRLSHIKEEVKPDISQLNDSNNSSFSPKAESPVPFMQAMSMVHVLPGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEAEQRAETQCGDRALTFLRVGPYSTVQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQLEAPPPPGLAMKLE
Protein: DNA polymerase epsilon subunit 2 (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) (P56282)
Organism: Homo sapiens (Human)
Function: Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- DNA replication licensing factor MCM3
- Cell division control protein 45 homolog
- DNA polymerase epsilon subunit 3
- DNA polymerase epsilon catalytic subunit A
- DNA polymerase epsilon subunit 4
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM5
- DNA polymerase alpha catalytic subunit
- DNA replication complex GINS protein PSF2
- DNA replication complex GINS protein PSF1
Sequence:
MAPERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSNMIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLFGTPRDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTTKIGDAIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAFGFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEVLEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSRFVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLVNKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVIADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGF
Protein: Reticulon-like protein (Q9VMW4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363132}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363132}.
Interaction partners:
Sequence:
MAGGSKRYSRNNSNGNFQPLPERGPVESLIYWRDVKKSGIVFGAGLITLAAISSFSVISVFAYLSLLTLFGTVAFRIYKSVTQAVQKTNEGHPFKDYLELDLTLSHEKVQNIAGVAVAHINGFISELRRLFLVEDIIDSIKFGVILWVFTYVGAWFNGMTLVILAFVSLFTLPKVYENNKQSIDTHLDLVRSKLTEITDKIRVAIPIGNKKPEAAAESEKDK
Protein: PR domain-containing protein 11 (EC 2.1.1.-) (A2AGX3)
Organism: Mus musculus (Mouse)
Function: May be involved in transcription regulation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9NQV5}. Cytoplasm {ECO:0000250|UniProtKB:Q9NQV5}.
Interaction partners:
Sequence:
MTENMKECLAHTKAAVGDMVTVVKTEVCSPLRDQEYGQPCSRRLEPSSMEVEPKKLKGKRDLIVTKSFQQVDFWFCESCQEYFVDECPNHGPPVFVSDTPVPVGIPDRAALTIPQGMEVVKDAGGESDVRCINEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGERLRVWYSEDYMKRLHSMSQETIHRNLARGEKRLQREKAEQALENPEDLRGPTQFPVLKQGRSPYKRSFDEGDIHPQAKKKKIDLIFKDVLEASLESGNVEARQLALSTSLVIRKVPKYQDDDYGRAALTQGICRTPGEGDWKVPQRVAKELGPLEDEEEEPTSFKADSPAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPSLLPPQVLELPEFSDPAGKFLRMRLLLKGRVCSATRAHCVEGGPERSALSQPPARRPEECNSAEAAPSWGGSPVPQVTEAGWLEDRGREGIACANLYILLVNKICPICRRAVCCVLDLVFSLGGGAHCCLP
Protein: Discs overgrown protein kinase (EC 2.7.11.1) (Protein double-time) (O76324)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim). Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. No evident circadian oscillation is detected in head. Together with CkIalpha, regulates processing of ci by phosphorylating it, which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase.
Subcellular location: Nucleus {ECO:0000269|PubMed:26082158}. Cytoplasm, cytosol {ECO:0000269|PubMed:26082158}. Note=Detected in the nucleus and cytoplasm of the small and large lateral neurons (sLNv and lLNv). {ECO:0000269|PubMed:26082158}.
Interaction partners:
- Period circadian protein
- Circadian locomoter output cycles protein kaput
- Protein timeless
- Cadherin-related tumor suppressor
- Protein cycle
- Supernumerary limbs, isoform B
- Protein limb expression 1 homolog
- Segment polarity protein dishevelled
- Protein kinase shaggy
- Transcriptional activator cubitus interruptus
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQGGIGIPRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRDIKPDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPWQGLKAANKRQKYERISEKKLSTSIVVLCKGFPSEFVNYLNFCRQMHFDQRPDYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGGPRNPQAIQQAQDGADGQAGHDAVAAAAAVAAAAAASSHQQQQHKVNAALGGGGGSAAQQQLQGGQTLAMLGGNGGGNGSQLIGGNGLNMDDSMAATNSSRPPYDTPERRPSIRMRQGGGGGGGGVGVGGMPSGGGGGGVGNAK
Protein: Zinc finger protein 121 (Zinc finger protein 20) (P58317)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MAEIHNGGELCDFMENGEIFSEHSCLNAHMGTENTGDTYDCDEYGENFPMLHNSAPAGETLSVLNQCRKAFSLPPNVHQRTWIGDKSFEYSDCEEAFVDQSHLQANRITHNGETLYEQKQCGRAFTYSTSHAVSVKMHTVEKPYECKECGKFFRYSSYLNSHMRTHTGEKPYECKECGKCFTVSSHLVEHVRIHTGEKPYQCKECGRAFAGRSGLTKHVRIHTGEKPYECNECGKAYNRFYLLTEHFKTHTEEKPFECKVCGKSFRSSSCLKNHFRIHTGIKPYKCKECGKAFTVSSSLHNHVKIHTGEKPYECKDCGKAFATSSQLIEHIRTHTGEKPYICKECGKTFRASSHLQKHVRIHTGEKPYICNECGKAYNRFYLLTKHLKTH
Protein: Protein WVD2-like 7 (Q67Y69)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8GYX9}.
Interaction partners:
- Probable calcium-binding protein CML50
- Probable calcium-binding protein CML49
- Probable calcium-binding protein CML48
- Stomatal closure-related actin-binding protein 1
- AP-3 complex subunit mu
- E3 ubiquitin-protein ligase MBR2
- Cytochrome P450 superfamily protein
- Cytochrome P450 superfamily protein
- Cytochrome P450 superfamily protein
- Cytochrome P450 superfamily protein
Sequence:
MAGEIQDPFSLSFQGNSIHSGSISFGRFEKEGLSWEKRSSFSHNRYLEEVDKCSKPGSVTEMKAHFEAHFKKKGIRFPASLESQTWGVHQTSNEPDDEAVHATESFEDYRSDGSFSEDTSQSNSVCNYSHEQEKCGQGKSQCEFDEESDHCVSYDEILVNSDEVIELDEEEGGGDHGRVADLVECENLGPPEMPQEIVIQDSALVEEAGSKLDEHASKKPSNSMETPSSSVNVKPIIPNDVRVTKASTKGHDVTPKAASRRTKGSSLSSNSKTNVDAKSQKELRPKKTIESQPKSSNKTETRPPIATNRCKTSTTSSKLEMSTGSTSFRFKCSERAEKRKEFYMKLEEKIHAKKTETNQVQAKTQQKAEAEIKQFRKSLNFKATPMPSFYNIGTRPVSHNKTEPSKVAQSRSRPATSASITNRAVTRVSYKHGFEEAEMVKVMVSNRKQSAAKDSDLQKGNLMAVEMKQQIGARRSRN
Protein: Abscisic acid receptor PYL2 (PYR1-like protein 2) (Regulatory components of ABA receptor 14) (O80992)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA. Can be activated by both (-)-ABA and (+)-ABA.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9FLB1}. Nucleus {ECO:0000250|UniProtKB:O49686}. Cell membrane {ECO:0000250|UniProtKB:O49686}. Note=Localizes at the plasma membrane in the presence of a CAR protein. {ECO:0000250|UniProtKB:O80920}.
Interaction partners:
- Protein phosphatase 2C 16
- Protein phosphatase 2C 77
- Protein phosphatase 2C 56
- Protein phosphatase 2C 37
- Protein phosphatase 2C 7
- Probable protein phosphatase 2C 75
- Probable protein phosphatase 2C 78
- Protein phosphatase 2C 3
- Probable protein phosphatase 2C 24
- Serine/threonine-protein kinase SRK2D
Sequence:
MSSSPAVKGLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHDDE
Protein: Inscuteable (Q9W2R4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD33695p
- G protein alpha i subunit subunit alpha 65A)
- Bazooka, isoform B
- Atypical protein kinase C
- LD29223p
- Protein numb
- Protein deadpan
- Mushroom body defect, isoform H
- Miranda, isoform A
- Partner of numb
Sequence:
MSFQRSYSKVWWGSEQSSLTSGGFYSSFSGGSSTSSTSNYPQRQPASLGPLGNLSCIQEVEDEQNSSKLSWHKHDSPGSLRSQDSGFSDNEESHQLQHQQNLSPPSPQSDKQQTPAATPTSVHSVATPPTVVRRVGNSSFYSPLISVTRRISFTSGQITPKTRSGDEDAEDAELEASRSRLFEQLDSMKLDDGEAEAEEDSPPRPAIRRRRRLMRKPMPEPEAASASEEEEVVIAPPPPPPYNNETVYLGEAPPPYNNETVTFGATEQDESLQQQPSPLRVRSLRFTASTSTPKSGSKIAKRGKKHPEPVASWMSEQRWAGEPEVMCTLQHKSIAQEAYKNYTITTSAVCKLVRQLQQQALSLQVHFERSERVLSGLQASSLPEALAGATQLLSHLDDFTATLERRGVFFNDAKIERRRYEQHLEQIRTVSKDTRYSLERQHYINLESLLDDVQLLKRHTLITLRLIFERLVRVLVISIEQSQCDLLLRANINMVATLMNIDYDGFASLSDAFVQNEAVRTLLVVVLDHKQSSVRALALRALATLCCAPQAINQLGSCGGIEIVRDILQVESAGERGAIERREAVSLLAQITAAWHGSEHRVPGLRDCAESLVAGLAALLQPECCTQTLLLCAAALNNLSRMEATSHYSIMSNEAIFRLIDTLEHQTCGTSVFLYEQIVGMLHNMSLNKKCHSHLANGVIINFITSVYQTEFYQTYGSRAESDAQRRTIKTILHTLTRLASDSPTLGAELLEQWHLPDLLRQSLALKPANSQQQQHLDSSYGGDISQLARQLLRAHGQEQQLLQATPAPGGSFSSGHQTPEAQTQTNSSGMSSSGSKTKAKSSASPLLKFNLTRQESFV
Protein: Kunitz-type serine protease inhibitor BmKTT-2 (Delta-KTx 3.1) (P0DJ50)
Organism: Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Function: Dual-function toxin that completely inhibits trypsin activity at a molar ratio of 1:1 (dissociation constant of 420 nM) and that inhibits mKv1.3/KCNA3 potassium channel currents with an IC(50) of 371.3 nM.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
Sequence:
MMNVITVVGIILSVVCTISDAEGVDCTLPSDTGRCKAYFIRYFYNQKAGECQKFVYGGCEGNSNNFLTKSDCCKQCSPGKC
Protein: HTH-type transcriptional regulator GbdR (Glycine betaine/dimethylglycine responsive regulator) (Q9HTI4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Specific regulator of choline metabolism, which activates transcription of at least 25 genes from 11 promoters in response to choline metabolites. Required for the induction of plcH, encoding the phospholipase C, and pchP, encoding the phosphorylcholine phosphatase, in response to glycine betaine (GB) and dimethylglycine (DMG). Also controls the expression of gbcAB and dgcAB, which are required for GB and DMG degradation, respectively, in response to both GB and DMG. The GbdR regulon also includes genes encoding sarcosine, glycine and serine catabolic enzymes, the BetX and CbcXWV quaternary amine transport proteins and the acetylcholine esterase gene, choE. Acts by binding directly to the promoter region of the genes. May play an important role during P.aeruginosa interactions with eukaryotes. Is critical for induction of plcH and pchP in response to bovine surfactant and mouse bronchoalveolar lavage fluid (BALF).
Interaction partners:
- Glycine betaine monooxygenase oxygenase subunit
- Phosphorylcholine phosphatase
- Glycine betaine monooxygenase reductase subunit
- ChoE
- Sarcosine oxidase gamma subunit
- Sarcosine oxidase subunit beta subunit beta)
- Sarcosine oxidase delta subunit
- HTH-type transcriptional regulator BetI
- DgcA, Dimethylglycine catabolism
- Hemolytic phospholipase C
Sequence:
MTTYAPGVPPQNRNPQSIGFLLLDNFTLISLASAVEPLRMANQLSGRELYRWHTLSLDGRQVWASDGLQITPDAGTDNAPAVDCVIVCGGVGIQRSVTREHVTFLQAQARQGRRLGAVCTGSWALARAGLLDGYDCSVHWECLAAMQEAFPRVAMSTRLFSIDRNRFTSSGGTAPMDMMLHLIGREHGRELSAAISEMFIYERIRNEQDHQRVPLKHMLGTNQPKLQEIVALMEANLEEPIDLDELAVYVNVSRRQLERLFQKYLHCSPSRYYLKLRLIRARQLLKQTSMSIIEVASVCGFVSTPHFSKCYREYFGIPPRDERQGQPLGQPVVLMPIPQDLALMPNSSALSALSQAQGESTFASVRI