wanglab/gogpt-training-data huggingface dataset:
Protein: Protein FAM3B (Cytokine-like protein 2-21) (Pancreatic-derived factor) (PANDER) (P58499)
Organism: Homo sapiens (Human)
Function: Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
Subcellular location: Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
Interaction partners:
- Spliceosome-associated protein CWC15 homolog
- M-phase-specific PLK1-interacting protein
- Cortactin-binding protein 2
Sequence:
MRPLAGGLLKVVFVVFASLCAWYSGYLLAELIPDAPLSSAAYSIRSIGERPVLKAPVPKRQKCDHWTPCPSDTYAYRLLSGGGRSKYAKICFEDNLLMGEQLGNVARGINIAIVNYVTGNVTATRCFDMYEGDNSGPMTKFIQSAAPKSLLFMVTYDDGSTRLNNDAKNAIEALGSKEIRNMKFRSSWVFIAAKGLELPSEIQREKINHSDAKNNRYSGWPAEIQIEGCIPKERS
Protein: RNA processing factor 1, putative (Q387E5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein MAK16 homolog
- Ribosome biogenesis protein NSA1
- Uncharacterized protein
- RNA-binding protein, putative
- rRNA processing protein, putative
- Pescadillo homolog
- Ribosome biogenesis protein, putative
- Eukaryotic translation initiation factor 6
- Nucleolar GTP-binding protein 1
- Nucleolar complex protein 2
Sequence:
MGKGARTKRSAGPVVKRQRHEVRHRATEVDPALVERYRSTRQPVKKSQLFEELREQTKDAKRFRREARERERKVLKENAPAKPIPKTKERMRLPDVTFVEDKNDAEILRDEADDEFASYFKEGRKPKILITTGEHPCFRTKLFVKEALWLFPNSIYRPRKKYNLKEITQFCINREFTDLIVVTDRLKEPYNLIISHLPEGPTAMFRVSNFMTHAQLKDPAPRTEHYPELIFKNFDTRLGRRINRLLECLFPATRDYEGRAVATFHNQRDYIFMRTHRYIFDSLDAVRIQEMGPRFTLRLLSLQSGTFDTQFGEYEWFRKKEHDDDKLEWYL
Protein: Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (SMG-5 homolog) (F1R7R1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in nonsense-mediated mRNA decay (By similarity). Does not have RNase activity by itself (By similarity). Promotes dephosphorylation of UPF1 (By similarity). Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). Necessary for TERT activity (By similarity). Required for normal embryonic development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UPR3}. Nucleus {ECO:0000250|UniProtKB:Q9UPR3}.
Interaction partners:
- Regulator of nonsense transcripts 1
- Regulator of nonsense transcripts 3B
- SMG7 nonsense mediated mRNA decay factor.
- Nonsense-mediated mRNA decay factor SMG8
- Uncharacterized protein.
- Nonsense-mediated mRNA decay factor SMG9
- Regulator of nonsense transcripts 3A
- Serine/threonine-protein kinase SMG1
- Telomerase-binding protein EST1A
- Eukaryotic initiation factor 4A-III
Sequence:
MSGPSQDSEPEAKVLHIKRLYRAVVETVHKLDIIISGKSSYREVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQVIKTNKKHIHSRSALECAYRTHLIAGVGFFQHLLLYIQSHYQLELQDCIDWTHVTDPLIGRKKPVSATSKEMEWAQMACHRCLVYLGDLARYQNELAGVEAEQLAERFYHQALSVAPHVGMPFNQLGTLAGSKFYNVEATYYYLRCIQSETPFDGAYGNLKRLFDKASKMYHQVKKQEMKKLSPSRQRSKDIKRLLVSFMYLQSLLQPKNSLMETELTSLCQSVLEDFNLVLFYLPLPAHGSQSASEEEEEHDSVGSVLPDSLIFKMVVICLMVVHSLKRGASKQYSASIAFTLALFSHLVNHVNIRLQAELEEGESDVPALRTDNTDDADARDHSSAALSEERTLQNGSLEEDDDEEEEEKENGEDEPKGNGRTVATKKNQEKKRSAEEKQKQKRKFSRLSMLRRRRCAHKEDESDLSEGFESDEEEEEEEEGGGGGLVDGLGAPRVQMNSLGRDTRKGPLPEDGGWESGSEEDEGGTAFDVETDSDMNSQESRSDLEDMEDAENAPQQPQQEENEQPQTSREENATPPVTNGPSVSNDASISSNLQAMSSQLFQAKRCFRLAPTFSNVLLRPATTTPPAPESNPAPVQEITPPTGETPRNTSPEIANGTNDKDPDSNSEGSEHSNHSFHSEKTLSERLEILTNQGLIQVVKVFLDWLRTNTDIILMCAQSSQSLWNRLSVLLNLLPEGSKILETDIGLNKDVTELLSECEHPSLAQTLLLPEDMALRHLPALSIAHRRLDFTSQRPPLTPLDECVVRVCCIRSFGHFLTNLQGNVLHFNPEAGIFTSISQSEQDNLVQQAKAQFRMAEEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSSMSPYLVPDTAVLCQHLGLLRQLAASGCFIIIIPRTVIDGLDMLKKENSGARDGIRFLETEFRKGNRYIRCQKESGRSFERDKLKRQDTEAWHLYKMVDSCRQLTGSQSSGDEDTAGMVTILTGHSLEELSERSASMKAAVQAVAAAGMELKNIIEFYRQWKEMG
Protein: Guanine nucleotide exchange factor (G5EFE1)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Ras-like GTP-binding protein rhoA
- Guanine nucleotide-binding protein alpha-12 subunit
- Ras-related protein ced-10
- Cell division control protein 42 homolog
- Rho-GAP domain-containing protein
- Rho-associated protein kinase let-502
- Plexin-2
- CRAL-TRIO domain-containing protein
- DH domain-containing protein
Sequence:
MRSYEFVTNTPLKLDRHKVYLVDDVAVTRTVPLSQPLSPSTASSSYNMIERCVVVQRQPDGFGLTVNSEFPVYVHTLKQDGAAYCAGVRQGDRIVKVNGMSVSPNNHKEVLQMISNGHNVALTLLGKPPDPISNISFPNQQVEQKIHIADPVLIEASSKSWRQRRNELLGQMVAEERRNVEGLRESSQNGEKIDRALKRIVSLQSQLKQLKPESIISDSQKSLTNLNMDIDSDEEENDVVYLPESQGGPFSNLAELKTHPAHLAVFINYLLLHGNPSSLFFYLITDAYQSAYGTAKEFRRWAFEIFSTFIIPNSPMCIPNSNQSVIQPIDKIMCMTAEHIGDSDTDTLKRIFVPGRQRAVTDINMYLNDFRQKKQLGGQVSESTNQLTHMVRGDMTMEHRVGEQMLFRCLEQCSNSTDFDSCEIRTQSIISSLATVIKIVLGKTSSSSNEKMLDKFPQFMARDKPPGKSRKLPANIKNRIQVKGHSFSINSVNTVHYCYQCRDAIWGMQPWIYFCSNCDVKVHPHCTSALTDACYPVTQSKQKSKSRLSGLIGRSDANDDEDSGSNARHEQPNVKSTSSDSGIGGEHNMDRGLVSRSHSMRYRVATLPQSLSEDKVSIPSSKRDRSVTPSWQRSTGYDLTPADEIDESDIGDRKSKYLERRSLESSSRMAIDLQSVSAASSCSHHSGSVAMDDDICVRRTTTLQFSRFMDGDSDFEIETEATPLEQLIGWDVIRHLKPKEKKRQEVINELFHTERTHVRNLKILYHVFYKPIVTSKIVTEELANLLFANLEELLNLHKSMSDAMRAEVEKWRSAPPRVNGGIYGDIGVLMESMFDGEAAENLMRVTATFCQHQQHALEFLRTRCKREKDDAFVRFLAEAESNPVCRKLQLKDMIPVEMQRLVKYPLLLETIAKYTTEPSEEQNCLLRTVASAKRILSAVNTAKRNAENLRRLEELQKRTDTSPFDKEFVGHDYTNLNLTKFRLVHDGPLTCRFNRGKMIELHVVLLENMLVLFTKNSDGNKLVLKALEPSKETRWSPILPLAPLIAKEKANDKRAFFLIFNSQYGAQIYELVAGTATERKTWFKLMGDQIMSEKKNQAAGIDHNFDVSAQTTLDSDGVAKVNVVTHPRLVNANEITIQQPTILEHAQPVLTPAEKLKRSDEIIIQTLITKQTILAQFLSNDDSKGNTEELEKITEVLGGLAVVDLKQRDGKELAMSAIVHGNRLLDSINQSLNIRKEMGENGLDIYILNNQEPNVPSVPSYKLTAIAAPLMNHLKALMQVIQDQQNELNLVKQQLYHYKKLASDVDTRDRSVSEETLTDLGEDRKMVPKRPRLPSIQPMT
Protein: Uncharacterized protein YGR117C (P53270)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
Sequence:
MADNSTSRFYTNLLIANYLKHNGLEDTLAAFIRETALPLSALEKSDSSNSNVGEIPLEDLQSVVEDRIYYKRRSFKDRFKTLSINDDLAPIDNAKYGIQPWNHSLKFSIDVKLNKSLPKDTLFISATFTEDSKYILLSSATGYLVIYDIEKATSKSFKINEKVKSIVKLYGPIGSSGYQYVCPMNGSFYLLNNDFELVNNAVWKIHARMITHIKICNVTESSWFVITSGMDNFLRLSLLEIKNGNTFLTKLSEIKLASNCTSLNVIANGDGNGQNSFSVFLTRAEYTHIACYSIIDAKNLVHSYNIALNNAEFSTYAFNIRDVMAVDYVHSNTKDTIGLSPSTMLVVATSHKPYMRLILVEIPMNTGHPKAMKLDKVQTYYDKILRNFATEIYQDDFSLPILGKLESSNGVLVGNDEGIYSVDLMTGDSRILNIPGEANSLHDRIKCMDISKDQMRMVAGTSTKSIYILNVIRNAQ
Protein: Scm polycomb group protein-like 2 (Q8BYC8)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MGQTANEDHFDWDKYLKETGSISAPSEYFRQSKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNTSSWPMFLLRVLTGSELAPAVFFKEEPPRPLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKIVEKRPRRKRRTRLWRLRTALLGNEEEAPEAAEEPGTSVLTFGDENRTLKDCRGEAAEEPGTSAFTFGDENRTLKDCQGGWKKPKGRGFIKPGKDETRPGKHDQGAPAGKKPRGRGFTQPLEDEARPGRDVQVAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKPKGKRVTKSRKDQAQFLADEEAMPALSVSSTERTPPSSSEQPKSSTSGKTKSTSRGAQTSRKSPRKTSVVQPVPKTSKKAGKSKSTGNTSSPKKGITIKIVLPKKKGGKSGKKEKSIPVISSTSSASLSTLMKSSSSNKTSAGPSKIVMSTVCVYIHKHGDCGPFLDPQKVQQLPNHFGPGPVNVILQRTVQACVNCAFQAKDVFLFLKTDNRGGEMITAFFDGKVHTVQLPPVNSASFALRFLENFCQSLQCDNFLSSQPFRREAQVPTPDTGTDQSKPENGEPKEKRSLKRLSLHPHRSAPVSSKVPRKSGQASKGN
Protein: Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),-interacting protein (liprin), alpha 1 (S4R1D4)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XERMAALEDKNSLLREVENAKKQLEETQHDKDQLVVTIEALKAELEQMRLRGPSLHHGRPHLGSVPDFRFSVADGHVDAYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDVDVSDGEDDRDTLLSSVDLLSPSGQADAQTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLAGSSPPGSGRSTPRRVPHSPAREVDRLGVMTLLPASREEVRDDKTTIKCETSPPSSPRPLRLDRMHKGAPHTVSHEDIRDLRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGPLGKESPGQVGVSETENSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRQFPVWNYVPEKAKL
Protein: Vacuolar protein sorting-associated protein 53 (GARP complex subunit vps53) (P87129)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in retrograde transport from early and late endosomes to late Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Vacuolar protein sorting-associated protein 54
- Vacuolar protein sorting-associated protein 52
- Vacuolar protein sorting-associated protein 51
- t-SNARE affecting a late Golgi compartment protein 1
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 4
- Conserved oligomeric Golgi complex subunit 2
- Thioredoxin reductase
- Protein transport protein sec20
Sequence:
MSNGNDNSLIIKNIGNNEFKFVETLHELLPEDITYDDLGSLRLSLSERLQESVKKLDANKKTYEDAKLSMGEKMDDLNSSIVSLLQELSTLQSVAENTQSSIVQMTSEIKNLDFAKQNLATSMTMLKRLQMLVTAYEKLRTLRQNQKFGEAISLMQATLQLLNFFKKYRSVERIASLSRSISEFQKSFYEQVFDTFQSQFKKESGMRGGFSPSSVQYLNELCRFIDIFAGDPPESVIRWYCRHQLEDFMKVFRENEEAGSLENLPRRYTWFKKLLQTYDQLHKPIFPPHWKVDFRLYEVFCEETKNDLSKLLKDDRLSLQVFVASLEQTLEFESFIDHRFYNTKSRFNSNFEPKERQAYNALSSVFEPHYTLYFNQQSQEFSILFENFALEKQTSTDESSQVLSSSIKLFQAYRKTLTQFVRLTRSSPLVGLKNLFIKWLRRYTQVELLDYQESSTFKDIAIRLNTAEYIYRTTIELEKRFQEISNKEFKDKMSFSEVLEVISSSRGTLLKFATGKFENVLNSDLEPLSKMDLKNIETVGDQSSYVGGAVQNMTAKASEFLSVVDLNMFARNFCDRSCESFTRQFLNAIYLAKPISEVGAEQLLLDLYSFKNALLKLPDLKQDYSITDSYINHLTIFMGYIETVLKTLLTPASPKAGFIQSYIFLVKDRSVTNFTVLLELKGVGKSDISSFLQQFSDFVKKTPQLEESSPIFKYLTINTAVEQAATRSRLSLDLAPESSRTLQNLGRLFTSKKKHV
Protein: Tetraspanin-32 (Tspan-32) (AML1-regulated transmembrane protein 1) (Protein Phemx) (Q9JHH2)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Integrin beta-1
- Integrin beta-4
- Integrin alpha-6
- B-lymphocyte antigen CD19
- Integrin beta-8
- Integrin alpha-7
- CD9 antigen
- Peripheral myelin protein 22
- CD63 antigen
- CD151 antigen
Sequence:
MGHWNRIKIAKCQILITNFLVLLLGLSMATMVVVIHFGDHFTVIGHASLERNPYETLRYWAFYVGISLAGLLSLGAALSTIATVREAHGLMAAGFLCFALSFCILVQVAFWRFYNPTQVEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREDCLQSIRNVLWTHYSIASILTCTSLALTVYAMMLCAFLWFAIHSYHGLDRKGRYSLTPPRSHGFQTQEPSLFRWT
Protein: Heat shock protein family B (small) member 7 (Uncharacterized protein DKFZp779D0968) (Q68DG0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSHRTSSTFRAERSFHSSSSSSSSSTSSSASRALPAQDPPMEKALSMFSDDFGSFMRPHSEPLAFPAHPTARPGGAGNIKTLGDAYEFAVDVRDFSPEDIIVTTSNNHIEVRAEKLAADGTVMNTFAHKCQLPEDVDPTSVTSALREDGSLTIRARRHPHTEHVQQTFRTEIKI
Protein: Palmitoyltransferase (EC 2.3.1.225) (A0A8I6A4S3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004653}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004225}.
Interaction partners:
Sequence:
MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAIPVYNGILFLFVLANFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHMVGVVAFGLLYVLNHSEGLGAAHTTITPAWLSCVWLAFSSFLSSASLASTWYWSPGDAPPMSRYVVEAPRMPLSVSLKPPFLRPELLERAVPLKVKLSDNGLKAGRSKSKGSLDQLDEKPLDLGPPLPPKMEAGTFGRDLKTPRPGSAESALSVQRTSPPTPAMYKFRPAFSTAPKTPFCGPSEQVPGPDSLTLADDSTHSLDFVSEPSLDLPDHGPGGLHPTYPPSPPLSATDAFSGALRSLSLKAASRRGGDHMTLQPLRSEGGPPTPHRGLFAPHALPNRNGSLSYDSLLNPGSPSGHACPTHPSVGMAGYHSPYLHPGPSDPPRPPPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQTDSLFGDSGVYDTPSSYSLQQASVLTEGPRGSVLRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSMSRAPRTSSSSLQADQANNNAPGPRPGSGSHRSPARQGLPSPPGTPRSPSYSGSKAVAFIHTDLPDRQPSLAMQRDHPQLKTPPSKLNGQSPGMARLGPAASPMGPNASPARHTLVKKVSGVGGTTYEISV
Protein: Protein METHYLENE BLUE SENSITIVITY 1 (Q9M8S0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for acclimation to reactive oxygen species (ROS) responses downstream of beta-cyclocitral (beta-cc) or mediated by dihydroactinidiolide, including singlet oxygen 1O(2) detoxification reactions, especially upon light-mediated photooxidative stress, and leading to programmed cell death. Prevents leaf senescence. Involved in cold acclimation.
Subcellular location: Nucleus {ECO:0000269|PubMed:24151292, ECO:0000269|PubMed:27813110}. Cytoplasm {ECO:0000269|PubMed:24151292, ECO:0000269|PubMed:27813110}. Cytoplasm, Stress granule {ECO:0000269|PubMed:24151292}. Note=Moves from homogeneous distribution in the cytosol to discrete spots (e.g. stress granules (SGs) and processing bodies (PBs)) in response to singlet oxygen 1O(2) exposure (PubMed:24151292). Accumulates in nucleus after beta-cyclocitral (beta-cc) treatment (PubMed:27813110). {ECO:0000269|PubMed:24151292, ECO:0000269|PubMed:27813110}.
Interaction partners:
- Trihelix transcription factor GT-4
- Scarecrow-like protein 14
- Coiled-coil domain-containing protein 86
- AT5g28150/T24G3_80
- AT4g02720/T10P11_1
- F-box/kelch-repeat protein At3g23880
- Small ribosomal subunit protein eS12z
Sequence:
MTGKAKPKKHTAKEIQAKIDAALTNRGGGKAGIADRTGKEKGGHAKYECPHCKITAPGLKTMQIHHESKHPNIIYEESKLVNLHAVLAPVAESKPKPGIRGSLKK
Protein: Thioesterase PikA5 (EC 3.1.2.-) (Editing thioesterase) (Thioesterase II) (TEII) (Type II thioesterase) (Q9ZGI1)
Organism: Streptomyces venezuelae
Function: Involved in the biosynthesis of 12- and 14-membered ring macrolactone antibiotics such as methymycin, neomethymycin, narbomycin and pikromycin. Responsible for removing mis-formed acyl moieties (aberrant decarboxylation) that are bound to the PKS and could block it. Catalyzes the cleavage of methylmalonyl-[acp]. It exhibits some acyl-group specificity, and catalyzes the cleavage of propionyl and butyryl derivatives faster than acetyl malonyl or methylmalonyl derivatives.
Interaction partners:
Sequence:
MTDRPLNVDSGLWIRRFHPAPNSAVRLVCLPHAGGSASYFFRFSEELHPSVEALSVQYPGRQDRRAEPCLESVEELAEHVVAATEPWWQEGRLAFFGHSLGASVAFETARILEQRHGVRPEGLYVSGRRAPSLAPDRLVHQLDDRAFLAEIRRLSGTDERFLQDDELLRLVLPALRSDYKAAETYLHRPSAKLTCPVMALAGDRDPKAPLNEVAEWRRHTSGPFCLRAYSGGHFYLNDQWHEICNDISDHLLVTRGAPDARVVQPPTSLIEGAAKRWQNPR
Protein: Esterase FrsA (EC 3.1.1.1) (Fermentation/respiration switch protein) (P04335)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the hydrolysis of esters. Displays esterase activity toward pNP-butyrate. May stimulate mixed-acid fermentation by acting as a fermentation/respiration switch that down-regulates respiration and up-regulates fermentation rates.
Interaction partners:
- 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
- Esterase YpfH
- Methylglyoxal reductase DkgB
- Esterase YqiA
- Esterase YbfF
- UPF0294 protein YafD
- Cell division protein ZapC
- UPF0227 protein YcfP
Sequence:
MTQANLSETLFKPRFKHPETSTLVRRFNHGAQPPVQSALDGKTIPHWYRMINRLMWIWRGIDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWATQAMVWQQKACAEDDPQLSGRHWLHAATLYNIAAYPHLKGDDLAEQAQALSNRAYEEAAQRLPGTMRQMEFTVPGGAPITGFLHMPKGDGPFPTVLMCGGLDAMQTDYYSLYERYFAPRGIAMLTIDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLESPRLKAVACLGPVVHTLLSDFKCQQQVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGYWKNDPFSPEEDSRLITSSSADGKLLEIPFNPVYRNFDKGLQEITDWIEKRLC
Protein: Acrosin (EC 3.4.21.10) [Cleaved into: Acrosin light chain; Acrosin heavy chain] (P10626)
Organism: Capra hircus (Goat)
Function: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
Interaction partners:
- Spermatid nuclear transition protein 1
- Testis expressed metallothionein like protein
- ACD shelterin complex subunit and telomerase recruitment factor
- Izumo sperm-oocyte fusion 1
- cAMP-responsive element modulator
- Protein boule-like
- Piwi-like protein 2
- Acrosin-binding protein
- Zonadhesin
- Adhesion G protein-coupled receptor A3
Sequence:
RDNTTCDGPCGIRFRQNRXXXXRIIGGQDAAHGSWPWMVSLQIFTYHNNRRYHVCGGSLL
Protein: HECT-type E3 ubiquitin transferase (EC 2.3.2.26) (A0A8I5ZUV2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPSRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKANTRLKHCTPDSNVVKWFWKAVELFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE
Protein: DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) (O00273)
Organism: Homo sapiens (Human)
Function: Inhibitor of the caspase-activated DNase (DFF40).
Subcellular location: Cytoplasm.
Interaction partners:
- DNA fragmentation factor subunit beta
- Caspase-3
- Granzyme B
- Lipid transferase CIDEB
- Lipid transferase CIDEC
- Deoxyribonuclease-2-alpha
- Endonuclease G, mitochondrial
- Caspase-7
- Caspase-6
Sequence:
MEVTGDAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAYNNSDGGTAWISQESFDVDETDSGAGLKWKNVARQLKEDLSSIILLSEEDLQMLVDAPCSDLAQELRQSCATVQRLQHTLQQVLDQREEVRQSKQLLQLYLQALEKEGSLLSKQEESKAAFGEEVDAVDTGISRETSSDVALASHILTALREKQAPELSLSSQDLELVTKEDPKALAVALNWDIKKTETVQEACERELALRLQQTQSLHSLRSISASKASPPGDLQNPKRARQDPT
Protein: GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (A0A1W2PR74)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367138}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367138}.
Interaction partners:
Sequence:
XSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTRHFTGPDCRSTAWRCRKHLTKMELKAMVSDERGQSSK
Protein: Peroxisome biogenesis factor 2 (EC 2.3.2.36) (Peroxin-2) (Q9VSH8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004585}.
Interaction partners:
- RING-type E3 ubiquitin transferase
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX13
- Peroxisomal membrane protein PEX14
- Peroxin-19
- Peroxisomal biogenesis factor 3
- Peroxisomal targeting signal 1 receptor
- Peroxin-7
- Peroxisomal membrane protein PEX16
- Peroxisomal ATPase PEX6
Sequence:
MEKNKYVPRVNQIDAIYLNKDIARLIRDNLLENLQAISPVLFIKIQPELDLIIQSAIWFGSVGKRCSTFGQQLLVLAYDAEKLTVSRLVLHFILTVLPGYVKSWEERRLTRRVEWFSEAIMWVENSALILNILNYFRFLKTGRKPTLVDYLLGLDYISLRNNQRRDIGYKYLTRELLWGGFMEILGLVLPIINFRKLQRVLKSWTFSGRRLEDRDGPAFLAPQMTLSTTCTFCGERPTLPHHMGCGHIYCYYCLNANVLTDASFCCPNCGSACPESGIQSV
Protein: Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (PAM COOH-terminal interactor protein 2) (P-CIP2) (U2AF homology motif kinase 1) (Q8TAS1)
Organism: Homo sapiens (Human)
Function: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:23419774}.
Interaction partners:
- Stathmin
- Cyclin-dependent kinase inhibitor 1B
- Kv channel-interacting protein 4
- A-type potassium channel modulatory protein KCNIP2
- A-type potassium channel modulatory protein KCNIP1
- A-type voltage-gated potassium channel KCND3
Sequence:
MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL
Protein: Somatostatin-2 (Somatostatin II) [Cleaved into: [Tyr21,Gly24]-somatostatin-28; [Tyr7,Gly10]-somatostatin-14] (Q91194)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Somatostatin inhibits the release of somatotropin.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MKVCRIHCALALLGLALAICSQGAASQPDLDLRSRRLLQRARAAAWPHRSGVSERWRTFYPNCPCLRPRKVKCPAGAKEDLRVELERSVGNPNNLPPRERKAGCKNFYWKGFTSC
Protein: Vomeronasal 2, receptor 82 (A0A3B2WCJ4)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MLLSWLLIVWFLQMPTFTWIIATHICPTDTKHLIHSDGTVVIGAFFPILHNSRVSKIIDWRYFPMDSDDYFGINARNYQLVLAMLFAVNEINLNSHILPNTSLGLEIYNLPAIGRNIFRTVFSWLTGLSSVIPNYTCRKESKSAATLTGLSWKTSETIWTILDLYKFPQLHPFLKKIQVKNSVGDDVVLDWKRKADPEYDITNIWNFPTGLSLLVKVGTFVPSAPKGKQLSMSEYMINWPIGFTEIPHSVCSESCNPGFRKVALESKPTCCFDCTPCPDNEISNETGMDQCVHCPETHYASAEKRHCLKKTITFLSYNDPLGKGITLLSIGFSTLTALVIWVFVEHRGTPIIKANNRSLSYILLITLILCFLCPLLFIGLPNTATCIMQQYMFGLLFTVALSTVLAKTITVVMAFKITAPGRKIRWLLTSQVPKFVIPVCILIQVLLSGIWLGTSPPFIDKDYQSEHGHIIILCSKGSYIYFYCTLAYLGVMAFGSYLLAFLSRRLPDRFNESKSLAFSMLVFCSVWVMFLPVCHSTSGKVMVAMEMFSILASSASILIIVFAPKCYIVLFRPELNTLTHNRDKRHHRSKTLLKT