wanglab/gogpt-training-data huggingface dataset:
Protein: CWF19-like protein mug161 (Meiotically up-regulated gene 161 protein) (Q10414)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-splicing factor cdc5
- Pre-mRNA-splicing factor cwf19
- U2 small nuclear ribonucleoprotein A'
- Pre-mRNA-splicing factor cwf14
- Pre-mRNA-splicing factor cwf10
- Pre-mRNA-processing factor 19
- Small nuclear ribonucleoprotein-associated protein B
- Pre-mRNA-splicing factor cwf2
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor cwf4
Sequence:
MIFYDKLKPADVLVIGSADGRVIEAIEYIADLHKQHGFKFAICLGNLFSHKRTTSADVVKLKNEKVKVPIPVYFGVGTAGLPESIISHMAMYGPEVAPNLFCMGICGFMKTFYKFTIAQLGGSYNEEKYYQPPEKFEQSLNEKCFHRSDVQKLSKRCDILFSSEWPEDVQENSTLPERKLPKGCMPLAALAANCMPQYFFVPGPVYYEREPYKNSAAINVNTGTVTHFVALAPFKNSKNEKFSYAFTLYPLTTEYMQPAPPNCTASPFEHRPIPLKRASEDQIIPQQTNKFHKSKSSTALFKSKKDSSSSLNKMHKSESHSALNNLHKSESGTSLNNRRSKVGPGSCFFCLSNPNVALHLIVAIGNEAYMALPKGPLTTTASNTPALASSGHVLIIPIAHASALSTLSDTSYEKTLNEMNRFRKAVTDMYNACDSDALVYEISRANGVHLHWQMIPIPKISSHRIESVFLEMAKEAGYDFEERDVEPHELNYFRVFLPSGKILIHRLQLRERFDLQFGRRAAAKILGLEDRVDWRKCVQTEDEEKAESEAFKMCFKPYDFT
Protein: Hmr (Hybrid male rescue protein) (Q86CW4)
Organism: Drosophila simulans (Fruit fly)
Interaction partners:
Sequence:
MEEEPVANENGFQIIVSDTIGQKTNRVDNDKAPNPFSRSTYPESGDGGILQRYMAETQLIALVRNQPLLYDPRHPKFHDVAQREKKWKKIAHRLATNMDNCMTAWSELRYKFQRHVRRLRAFHRSAIQSDRAALRPWRPCMQYEEEMRFLYPHVSRYPLIVDKAQPTEIIETEQVVASETLPDVELVEVPPVDIIDVDLEEDPTYNYRCSKLQRRLIEAVNAYPLLYDTTYTGYQNTRHRGLIWSAISNEVHDKATKLMKCWLKLQTRYEWELIHRPRNIGTSELCRLMDFMEPHIQRMRGTVCKASKYLQNGWHEPIEHFHSVVALINTMRSMPELVQLTEDSLYKKVKPPRYDELWQKVGMEVMSGHERCEVTWLLLRAFYHELQAMRLSGYQLQDKWFFEGSISQALTHVASYSTARPALKRTANGAITLAGEPPAKIQALARMPLAIVYPPTTKGSSTSISNSASTATSIGPTFPNVRRSSGPAITNTSAAATNSVSSSVSTDQVHTTFVIPKITSAISVSSAYKIPPKLSPNVRISSKAAGAMGTGVSPIVTTNQMAGLNAKPQIPGLQVKLHTKTQMPSIPQMAPVVPRTVIRTTNPTNPAQTQDRVYGGPVSTQVDLLSGTLRSQNPSSIRSPPTQHTLPNFVPITTQSNITAKSNLPTPTAAPMVQIHQPFSKPMGSLSTTSSPAAAPIAPPGEPARAKTIPTKSKLPATTLANPKKYQPIVPAAVPTATRMAKPAAEPATELPVPTPPTATGQKTRVIRKTPLFPKSATQAASDKYATIRGTLASQAKSVGAALETVDMDNISAPVATPAKLPTVAKATTASQSAKEATAAGSASLGSQPEQLPLGDITVCLHENATTGNVLQIWCCNQATRYNLNMVRTATLIREVMAVPQLHNDNPQLADKCVEFWQAIAKKFHMPEEALRACWQFLASNMSVFPMIAPMSELMRPFKASVKVWEKSNRLFGKFDEIALKYQWLKHKDVLPAVIRFFAKHEHLYSDLRKPRPGEDAQASPQLTNQEKQEVWREARLKFPNLNHRDIWSMFKFAFRTYLDDLERGIENPWPHNWWQALEQLRFLVNVRYHPLEPYYYIVHNKISEEVKRCSMYEALTSSDPTDKTKSAPTSLLTGLTKEPMPWETEEAKRLLTGKLNSVRSVATLTQITPAPAPAPASAPDAQPIPVPDGVSVPKETSESEPASNATVKSHKDKNISTARKRSTPARNDTCPNLSPIEAFELCKQLRSQPNTYERASTLDKRTAWVRVSKELNATVTDCRLGLQYALREMRNLKMADPNNQCTMGHKYLHHMSEIYKQVKPNAQLTVRTPQQLNQLNKSLAKNTEEVKPLEFLPEINLSTCSPDLVVKNWSYAVGNLSTASQDALLGKMTQLFSKYAKKANPPPP
Protein: Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (1-alkyl-2-acetylglycerophosphocholine esterase) (EC 3.1.1.47) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase) (P18424)
Organism: Rattus norvegicus (Rat)
Function: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:14636062, ECO:0000269|PubMed:8820107, ECO:0000269|PubMed:9219904}. Note=Secreted into blood plasma (PubMed:8820107). Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (By similarity). {ECO:0000250|UniProtKB:P04180, ECO:0000269|PubMed:8820107}.
Interaction partners:
- Apolipoprotein A-I
- Apolipoprotein C-I
- Apolipoprotein B-100
- Apolipoprotein A-II
- Phosphatidylethanolamine N-methyltransferase
- Serum paraoxonase/arylesterase 1
- Apolipoprotein C-III
- Phospholipase D1
- Phospholipase D2
- Apolipoprotein C-I-like.
Sequence:
MGLPGSPWQWVLLLLGLLLPPATSFWLLNVLFPPHTTPKAELSNHTRPVILVPGCMGNRLEAKLDKPNVVNWLCYRKTEDFFTIWLDFNMFLPLGVDCWIDNTRVVYNRSSGHMSNAPGVQIRVPGFGKTYSVEYLDDNKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLAPRQQDEYYQKLAGLVEEMYAAYGKPVFLIGHSLGCLHVLHFLLRQPQSWKDHFIDGFISLGAPWGGSIKPMRILASGDNQGIPIMSNIKLREEQRITTTSPWMFPAHHVWPEDHVFISTPNFNYTGQDFERFFADLHFEEGWHMFLQSRDLLAGLPAPGVEVYCLYGVGMPTAHTYIYDHNFPYKDPVAALYEDGDDTVATRSTELCGQWQGRQSQAVHLLPMNGTDHLNMVFSNKTLEHINAILLGAYRHGTPKSPTASLGPPTKE
Protein: RAB5B, member RAS oncogene family (A1L1J8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Early endosome antigen 1
- Ras and Rab interactor 1
- Ras-related protein Rab-5A
- Rab5 GDP/GTP exchange factor
- GTPase-activating protein and VPS9 domain-containing protein 1
- Rab GDP dissociation inhibitor alpha
- DCC-interacting protein 13-beta
- DCC-interacting protein 13-alpha
- Rab GDP dissociation inhibitor beta
Sequence:
MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNPGGAAGRSRGVDLHEQAQQNKSQCCSN
Protein: trypsin (EC 3.4.21.4) (Q9CPN9)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Carboxypeptidase A1
- Bile salt-activated lipase
- Carboxypeptidase B
- Anionic trypsin-2
- Chymopasin
- Chymotrypsin-like elastase family member 3B
- Chymotrypsinogen B
- Pancreatic triacylglycerol lipase
- Chymotrypsin-like elastase family member 2A
- Trypsin-5
Sequence:
MKTLIFLAFLGAAVALPLDDDDDKIVGGYTCQRNALPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSRIQVRLGEHNIDALEGGEQFIDAAKIIRHPNYNANTYNNDIMLIKLKTAATLNSRVSTVALPRSCPSAGTRCLVSGWGNTLSSGTNYPSLLQCLDAPVLSDSSCTSSYPGKITSNMFCLGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGYGCAQRGKPGVYTKVCKYVNWIQQTIAAN
Protein: tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) (Q9BSV6)
Organism: Homo sapiens (Human)
Function: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
Subcellular location: Nucleus {ECO:0000269|PubMed:15109492}. Nucleus, nucleolus {ECO:0000269|PubMed:15109492}. Note=May be transiently localized in the nucleolus.
Interaction partners:
- tRNA-splicing endonuclease subunit Sen54
- tRNA-splicing endonuclease subunit Sen15
- tRNA-splicing endonuclease subunit Sen2
- Polyribonucleotide 5'-hydroxyl-kinase Clp1
- Cleavage and polyadenylation specificity factor subunit 4
- Cleavage stimulation factor subunit 2
- Cleavage and polyadenylation specificity factor subunit 1
- Probable arginine--tRNA ligase, mitochondrial
- O-phosphoseryl-tRNA
Sequence:
MLVVEVANGRSLVWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPLLLMPEEARLLAEIGAVTLVSAPRPDSRHHSLALTSFKRQQEESFQEQSALAAEARETRRQELLEKITEGQAAKKQKLEQASGASSSQEAGSSQAAKEDETSDGQASGEQEEAGPSSSQAGPSNGVAPLPRSALLVQLATARPRPVKARPLDWRVQSKDWPHAGRPAHELRYSIYRDLWERGFFLSAAGKFGGDFLVYPGDPLRFHAHYIAQCWAPEDTIPLQDLVAAGRLGTSVRKTLLLCSPQPDGKVVYTSLQWASLQ
Protein: HIG1 domain family member 1C (A8MV81)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000255|PROSITE-ProRule:PRU00836}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836}.
Interaction partners:
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Sequence:
MSSDNQWSADEDEGQLSRLIRKSRDSPFVPIGIAGFVTVVSCGLYKLKYRRDQKMSIHLIHMRVAAQGFVVGAVTLGVLYSMYKDYIRPRFFSESKK
Protein: One cut domain family member (Q6PHC9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Forkhead box protein A2
- Neurog3 protein
- Forkhead box A1
- Pancreas transcription factor 1 subunit alpha
- NK6 homeobox 1.
- Hematopoietically-expressed homeobox protein hhex
Sequence:
MNAQLSMENIGDLHGVSHEPVHSAADLMTGDSAHHRSHRSSLSAHARSMGMASILDSGDYHHHRPPEHPGLATHLHPAMSMACEAPPGMSMSSTYTTLTPLQPLPPISTVSDKFPHHHHHHHHHHHHPHQRIPGNVSGSFTLMRDDRGLAPMNNLYSPYHKDVASMGQSLSPLSGSGLSGIHNSQQGLPPYAHPGATMPAEKMLTPNGFEAHHPAMLARHGEQHMSASSASMVPINVIHHHPHAHLNAQGHGQVLGSTREQNHSSVPGSQLNNGSSSGQMEEVNTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAGERTIACKRKEQEHGKGERGNISKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELATVSNFFMNARRRSLDKWLDDGSSNSANSSSSSTCTKA
Protein: Uncharacterized protein, isoform D (M9NEQ1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MADNAVQAQPNGLGPQKQKALELHFSQVSYSLKGATKGSTPIINEACGVFKSGRLTAILGPSGAGKSTLLNALAGFKLQGVTGQFLLNGRPRDIMSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLKMPSSTAAQEKQKIIDDIIDILQLQSCRRTLVKNLSGGEHKRLSIGIELVTNPPIMFFDEPTSGLDCVGSYQVICHLQRLAHDGRIVVCVVHQPGSRLFQLFDDVLVLAHGEVLYAGEQREMLPTFAQSGHICPQYYNPADFALEVCSQSSTTERCESLITQNKMMHSTASNVVKLQVDEETLIDVHKDALDLSHLRGKEQVGFWTQLSVLLRRHLRSMSRDMFAVQMRLVMHVVVALLLGVVYWQIGGDAQKIVSNVSCLFFVILFVFAGNAMPSILLCMQDSAVFIREYYNGWYSLGAYYLSKVLADLPLQLTCPTMFISIGYFMTGQPPEFQRFAMCWALCVMTAFIGHFIGVIAGSLFTMQLAIFLVPSATIPFLLFSGFFIRLNELSWFLRPICDVSFFRYIFEGLMRAIYGYDRGELECYATSNFCYYRTAEQFLKDFQMEGNEFDWDMAVLGIFLILLLLAFFVTLNAVIRRALR
Protein: Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 (H7C101)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTGTLFF
Protein: Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas 1) (FRAT-1) (Q92837)
Organism: Homo sapiens (Human)
Function: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.
Subcellular location: Cytoplasm.
Interaction partners:
- Glycogen synthase kinase-3 beta
- Segment polarity protein dishevelled homolog DVL-1
- Axin-1
- GSK-3-binding protein FRAT2
- Segment polarity protein dishevelled homolog DVL-2
- Segment polarity protein dishevelled homolog DVL-3
- Glycogen synthase kinase-3 alpha
- Catenin beta-1
- Transforming protein RhoA
Sequence:
MPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSPASPCGPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGRVRGRAAPYCVAELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRGAAASRRLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGPLSAPVHEPPSPRSPRAACSDPGASGRAQLRTGDGVLVPGS
Protein: Transmembrane protein (Q38BD4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLHIPRMASLPLTVIIAVASLSVVTSVAVGVESVDVAVEALHEAIISRDVAAVKLLLEKGDLKSKLKGYTPSPFYWVADEKNDSKKLDEIMNVLLEELDGEIEHDYGRYHPLTRAVHNRLSHVVDTLIHWPTTINEVLATYLLCDDVGFVPEGVTIVVTSYSRDCFFKFPQRVAYEHSKIAAVIRRRHREKFHEASKKSSSVKFDWENPFLTPPAGVKPPQNQHVMNPRAFTDFSQAFMYYFFGEWVSPYRFLYHAMWVVFGLLVCRVIVTAVRERSALAPVEPPPLAESPQGDMAAAPNTEDT
Protein: Collapsin response mediator protein 2 (Dihydropyrimidinase-like 2) (Dihydropyrimidinase-related protein 2b) (Q52PJ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MSGYQGKKNIPRITSDRLLIKGAKIVNDDQSFCADIYMEDGLIKQIGENLIVPGGVKTIDAHGRMVMPGGIDVHTRFQMPDRGMTAADDFYQGTRAALAGGTTIIVDHVVPEPGTSLISAFNQWREWADSKACCDYSLHVDITEWHKGVQEEMEALVKDHGVNSFLVYLAYKDFFQLTDSQIYEVFSVIRDLGAIAQVHAENGDIIAEEQRRILDLGITGPEGHVLSRPEEVEAEAVNRSVTVANQTNCPLYITKVMSKSAADVIAQARKKGTVVYGEPITASIGTDGSHYWSKNWAKAAAYVTSPPLSPDPTTPDYLNSLLSCGDLQVTGSAHCTFNTSQRAVGKDDFTLIPEGTNGTEERMSIIWDKCVVTGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADLVLWDPDVTKIISAKSHNLAVEYNIFEGMEVRGVPLVVISQGKIVLEEGTLHTTEGSGRFISRKPFPDYVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKAVTPASSAKTSPAKQPGQPVRNLHQSGFSLSGAQVDDNIPRRNTQRIVAPPGGRANITSLG
Protein: Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36) (O75344)
Organism: Homo sapiens (Human)
Function: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36150389}. Nucleus {ECO:0000269|PubMed:36150389}. Note=In spermatocytes, it colocalizes with PIWIL1 in large cytoplasmic granules (PubMed:36150389). Does not localize to the synaptonemal complex (PubMed:36150389). {ECO:0000269|PubMed:36150389}.
Interaction partners:
- Heat shock protein HSP 90-alpha
- Peptidyl-prolyl cis-trans isomerase-like 4
- General transcription factor II-I repeat domain-containing protein 1
- CDK5 regulatory subunit-associated protein 3
- Heat shock-related 70 kDa protein 2
- SUMO-conjugating enzyme UBC9
- Death-inducer obliterator 1
- Transducin beta-like protein 2
- Frizzled-9
- E3 ubiquitin-protein ligase TRIM50
Sequence:
MGGSALNQGVLEGDDAPGQSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLLLRRRSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFAPCGDGSTAGES
Protein: Trafficking protein particle complex subunit (Q5ASA2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Endoplasmic reticulum {ECO:0000256|RuleBase:RU366065}. Golgi apparatus, cis-Golgi network {ECO:0000256|RuleBase:RU366065}.
Interaction partners:
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit BET3
- Hypercellular protein A
- Trafficking protein particle complex subunit 2/Sedlin, putative
- PutativeTRAPP
- TMEM1 family protein, putative
- Trafficking protein particle complex subunit 11 domain-containing protein
- Transport protein particle
- DUF974 domain protein
- GTP-binding protein ypt1
Sequence:
MTVYSFYIFDRHAECIYKRRWLPRPASIVGKSSRPTSDTLTAANGIAPVPNQSARSTDDDAKLIFGTVFALRNMVRKLGGEDDNFVTYRTSQYKLHYYETLTNIKFVMITDVKSPSMRVALQQIYINLYVEYVVKNPLSPTEHPGGVGVNNELFEQSLEQFVTRVLA
Protein: YEATS domain-containing protein 2 (Q3TUF7)
Organism: Mus musculus (Mouse)
Function: Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9ULM3}.
Interaction partners:
- Cysteine-rich protein 2-binding protein
- SAGA-associated factor 29
- Protein Dr1
- Transcriptional adapter 3
- ZZ-type zinc finger-containing protein 3
- Transcriptional adapter 2-alpha
- WD repeat-containing protein 5
- MAP3K12-binding inhibitory protein 1
- Histone acetyltransferase KAT2A
- Transformation/transcription domain-associated protein
Sequence:
MSGIKRTIKETDPDYEDVSVALPNKRHKAIESSARDAAVQKIETIIKEQFALEMKNKEHEIDVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGLKTFDPMAFNHPAIKKFLESPSRSSSPTNQRSETPSANHSESDSLSQHNDFLSDKDNNSNVDVEERPPSTGEQRPSRKAGRDTSSISGSHKRELRNADLTGDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDSVYPQSSESDVCDAPPPTLTLPAAVKASAVAQSPEPAAAAPVGEGFPETTEAERHSTFYSLPSSLERTPTKVTTAQKVTFSSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQPITMSCKIVSGSPISTPSPSPLPRTPTSTPVHLKQGTASSGVSNPHVIVDKPGQVIGASTPSTGSPTSKLPVASQASQGTGSPIPKIHGSSFLTSTVKQEESLFASMPPLCPIGSHPKVQSPKAVTGGLGAFTKVIIKQEPGEAPHVSTTGAASQSAFPQYVTVKGGHMIAVSPQKQVISAGEGTTQSPKIAPSKVVGVPVGSALPSTVKQAVAISSGQILVAKASSSVTKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKTQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAAAGGSGSSGAGGGSGGGGGSGAGGTPSTSGPGGGPQHLTYTSYILKQTPQGTFLVGQPSPQTPGKQLTTASVVQGTLGVSSSSAQGQQTLKVISGQKTTLFTQAATAGQASLLKLPDNTLKSVPAAPQLAKPGTTMLRVAGGVITAAPSPAVAFSANGAVHQSEGSTPVSSSVGSIIKTPGQPQVCVSQATMATCKGPAAVAGTAASLVSAPSSISGKATVSGLLKVHSAQSSPQQAVLTIPSQLKPLSINTSGGVQTVLMPVNKVVQSFSTSKLPTTVLPISVPNQAAPSSAPVAIAKVKTEPETPGPNCISQENQVAVKTEESSELSNYVIKVDHLETIQQLLTAVVKKIPLITAKGDDASCFSAKSLEQYYGWNIGKRRAAEWQRAMTVRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRHDGDSIEDVLTQIDSEPECLSSFSTADDLCRKLEDLQQFQKREPENEEEVDILSLSEPLKTNIKKEQEEKQEEMRFYLPPTPGSGFVGDITQKIGITLQPVALHRNMYASVVEDMILKATEQLVSDILRQALAVGYQTASPNRIPKEITVSNIHQAICNIPFLDFLTNKHMGRLNEDQ
Protein: Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (Schmalspur protein) (Q9I9E1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:10996071}.
Interaction partners:
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog
- Teratocarcinoma-derived growth factor 1
- Mothers against decapentaplegic homolog.
- Nodal-related 1.
- Homeobox protein MIXL1
- Dr1-associated corepressor
- Left-right determination factor.
- Southpaw.
- Left-right determination factor
Sequence:
MTKHWGGPGLLAPPVITVGEGAQRDHHLDCRIGYSSSKRSCHRSSNPLLELGGRLDKSTGMAQDSCYRAKATNQGPWELQDGNSSGGKKKNYQRYPKPPYSYLAMIAMVIQNSPEKKLTLSEILKEISTLFPFFKGNYKGWRDSVRHNLSSYDCFVKVLKDPGKPQGKGNFWTVEVNRIPLELLKRQNTAVSRQDETIFAQDLAPYIFQGYSQPNKSKPLPPESSLPPVPTRQSPPPSEDPYRPKLDSTFAIDSLLHSLRPASSAGEGLRERESWGVGPPPHTRSTTPPRPCNASYNGSSSASSVSPASDFSDEDWRGVTVVGKRSGDRGITSDAYSDSCPPPNKSSKRGNTPPWELPTSYAKYTPPNAVAPPSMRFNGNPFMPLGGIPFYGYGGAHVTTSHLIGHPYWPILPSGPVSIQAPPLLMDLDSMLQSVPPNKSVFDALGSNNQTVHPSPNQYALQNGPSLCKYSL
Protein: Alpha-S2-casein [Cleaved into: Casocidin-1 (Casocidin-I)] (P02663)
Organism: Bos taurus (Bovine)
Function: Important role in the capacity of milk to transport calcium phosphate.
Subcellular location: Secreted.
Interaction partners:
- Alpha-S1-casein
- Kappa-casein
- Beta-casein
- Glycosylation-dependent cell adhesion molecule 1
- Alpha-lactalbumin
- Beta-lactoglobulin
- Lactotransferrin
- Mitochondrial fission regulator
- Retinal guanylyl cyclase 1
- Butyrophilin subfamily 1 member A1
Sequence:
MKFFIFTCLLAVALAKNTMEHVSSSEESIISQETYKQEKNMAINPSKENLCSTFCKEVVRNANEEEYSIGSSSEESAEVATEEVKITVDDKHYQKALNEINQFYQKFPQYLQYLYQGPIVLNPWDQVKRNAVPITPTLNREQLSTSEENSKKTVDMESTEVFTKKTKLTEEEKNRLNFLKKISQRYQKFALPQYLKTVYQHQKAMKPWIQPKTKVIPYVRYL
Protein: MAU2 chromatid cohesion factor homolog (MAU-2) (Cohesin loading complex subunit SCC4 homolog) (B4ZIX8)
Organism: Xenopus laevis (African clawed frog)
Function: Plays an important role in the loading of the cohesin complex on to DNA. Plays a role in sister chromatid cohesion and normal progression through prometaphase.
Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y6X3}. Note=Binds to chromatin from the end of mitosis until prophase. {ECO:0000250|UniProtKB:Q9Y6X3}.
Interaction partners:
Sequence:
MSVMAATAVVSPQAEASESWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFQFKPPQRIEARTHLQLGSVLYHHTKNSELARQHLEKAWFISQQIPQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDSSPILSSFQVILLEHIIMCRLVTGHKATALQEISQLCQLCQQSPRLFSNHAAQLHTLLGLYCISVNCMDNAEAQFTTALRLTTHQELWTFIVTNLASVYIREGNRHQELYALLERINPDHNFPVSSHCLRAAAFYIRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNNIDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGSPPVQFQAQNGPTTSLASLL
Protein: Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4) (Q969E2)
Organism: Homo sapiens (Human)
Function: Probably involved in membrane protein trafficking.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MSEKENNFPPLPKFIPVKPCFYQNFSDEIPVEHQVLVKRIYRLWMFYCATLGVNLIACLAWWIGGGSGTNFGLAFVWLLLFTPCGYVCWFRPVYKAFRADSSFNFMAFFFIFGAQFVLTVIQAIGFSGWGACGWLSAIGFFQYSPGAAVVMLLPAIMFSVSAAMMAIAIMKVHRIYRGAGGSFQKAQTEWNTGTWRNPPSREAQYNNFSGNSLPEYPTVPSYPGSGQWP
Protein: T-complex protein 11 homolog (Q8WWU5)
Organism: Homo sapiens (Human)
Function: Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q01755}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q01755}. Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. {ECO:0000250|UniProtKB:Q01755}.
Interaction partners:
- Zinc finger protein 76
- Zinc finger protein 143
Sequence:
MPDVKESVPPKYPGDSEGRSCKPETSGPPQEDKSGSEDPPPFLSVTGLTETVNEVSKLSNKIGMNCDYYMEEKVLPPSSLEGKVKETVHNAFWDHLKEQLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRIEIEEALDMDLLKQEAEHGALKVLYLSKYVLNMMALLCAPVRDEAVQKLENITDPVWLLRGIFQVLGRMKMDMVNYTIQSLQPHLQEHSIQYERAKFQELLNKQPSLLNHTTKWLTQAAGDLTMSPPTCPDTSDSSSVAGPSPNEAANNPEPLSPTMVLCQGFLNLLLWDLENEEFPETLLMDRTRLQELKSQLHQLTVMASVLLVASSFSGSVLFGSPQFVDKLKRITKSLLEDFHSRPEEAILTVSEQVSQEIHQSLKNMGLVALSSDNTASLMGQLQNIAKKENCVCSVIDQRIHLFLKCCLVLGVQRSLLDLPGGLTLIEAELAELGQKFVNLTHHNQQVFGPYYTEILKTLISPAQALETKVESV
Protein: Smr domain-containing protein (Q584J3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MHVTGCREGGEGGANGEMNPLQEVIEAPPEFIGHVIGEGGSTIKSLQCETGATITISDGCRVCITADNKEKLSDATSRVRDIINAAINPDYEGPEGSRLRKDAAAWATKRAELLDEVTRLRGEGKKHEVSLTLEEAKKAGEQMRLKNQEAANAIARHNNENKGKGKDYFDMHGLRVEEAVNMLKSRVERLREASVGEVAEMQIITGAGRHSGPEGAKLKKAVADFLRESNIEFVEVSTAELRAKIVGICRPVKETKVKKATCNCF