wanglab/gogpt-training-data huggingface dataset:
Protein: Protein charlatan (Q7YU81)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable transcription factor involved in the development of the adult pattern of macrochaetae. Required for accumulation of achaete (ac) and scute (sc) in proneural clusters. Probably acts by binding to the proneural cluster-specific enhancers of the ac/sc complex and increasing enhancer efficiency, thereby acting as a stimulator of ac/sc expression in proneural clusters. Also required for correct development of the embryonic/larval peripheral nervous system (PNS).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MATLIPVNGGHPAASGQSSNVEATYEDMFKEITRKLYGEETGNGLHTLGTPVAQVATSGPTAVPEGEQRSFTNLQQLDRSAAPSIEYESSAAGASGNNVATTQANVIQQQQQQQQQAESGNSVVVTASSGATVVPAPSVAAVGGFKSEDHLSTAFGLAALMQNGFAAGQAGLLKAGEQQQRWAQDGSGLVAAAAAEPQLVQWTSGGKLQSYAHVNQQQQQQQQPHQSTPKSKKHRQEHAAELIYASPSTSANAAQNLAQSTPTSAPSNSSGGSTSSSGGGGGRKKAAQAAAAAAAANGVHIQKRYACTHCPYSTDRRDLYTRHENIHKDEKPFQCYACLKQFNRADHVKKHFLRMHRELQYDINKTRRHVSAGSGSSGSGSSGSGSHHSGGRGNVTINSAGVNIDNAFLEAQRHPTSSSMSIVETIEAVASATDMPLAQLKQEKMDDGAGVVLPLHVGVMQQPVASSSSGSSGSHGGNGNGGSGSGLLKPKREKRFTCCYCPWSGADKWGLKRHLNTHTKPFVCLLCDYKAARSERLATHVLKVHNKRACSKCSYLADTQEEYQAHMSDVHGNVGNANGGGGAVTIYTTTTNEGVAGGGGGGGGGISGNISGGGPLQEIIVNPSSMVGWRLSANGSLIPPHDLLTGGLPNAATQKRGSERLFQYLEAEGSDPEDYARLLKMDAISRNTASVAQDFHKAGGVHELKIPANHQLLFNNKLPSQWTTREAAALLYSLSNMGGGSASSVSGSQRQKFGMRARQHSTGEDDENTPSSASSSSFSGDEFNMSATSPLKLSRHAIKLEKMDEMDAKDMGPTKAMMATAFLEAANYEQTAIELLASKRKIKVENDNDEDQENQQHQPHQQHHSQQQQQQRLQLIKSSPAYKLNNNNNNNSNNNNYYKDKTSHRNAVHHHRQDDKENNKTKSPGTAAVSVAAAAATSPPSISGPSNQTPFLTQMEYQNLNRIGTQFQNYVKDIINKYYAAETPLMLAAAAAALPTATTTGQQQQPELDIENLSPSKRRRLLSETEEYIEYLRNKEDITLTIAPKVQPPAPVTSLLKRQLDLSTPRRSPKKAAPAHSNSASNASRKSLNQLATLLPLLADAASQQEYLAAPLDFSKKSSSRKQAQPKKIRLTPEAVVTLLRDKYLNRMVRQRLGCLKCNQLRKNSSISFNYHTLGSLALHKYWRHGRLGSSSTRREKLQAALQKRISRGQADKC
Protein: Maturin (Maturin neural progenitor differentiation regulator protein homolog) (Protein Ells1) (Q8N3F0)
Organism: Homo sapiens (Human)
Function: Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression. Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536'. May be involved in early neuronal development (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24681962}.
Interaction partners:
Sequence:
MDFQQLADVAEKWCSNTPFELIATEETERRMDFYADPGVSFYVLCPDNGCGDNFHVWSESEDCLPFLQLAQDYISSCGKKTLHEVLEKVFKSFRPLLGLPDADDDAFEEYSADVEEEEPEADHPQMGVSQQ
Protein: Complement factor H-related protein 3 (FHR-3) (DOWN16) (H factor-like protein 3) (Q02985)
Organism: Homo sapiens (Human)
Function: Might be involved in complement regulation.
Subcellular location: Secreted.
Interaction partners:
- Complement C3
- Complement factor B
- Complement factor H-related protein 1
- Complement factor I
- Complement factor H
- A disintegrin and metalloproteinase with thrombospondin motifs 13
- RNA-binding motif, single-stranded-interacting protein 2
- Myosin-binding protein H
- Gamma-tubulin complex component 5
- Diacylglycerol kinase epsilon
Sequence:
MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGYNANTSILSFQAVCREGIVEYPRCE
Protein: Protein SPP41 (P38904)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Negative regulator of PRP3 and PRP4 genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- U4/U6 small nuclear ribonucleoprotein PRP3
Sequence:
MAYDEDDGEINFNELVGNLLSSHNQEGQEEGEVQGGEQEGDDFEKIYPTSENIEPKHPDDSQHMHNSPDQNIEIPHFVDEEDELVSVVANAVQNIDDEQAKPENHLENGSEHVTSDTADDNHEKEQQQEWAHILQQEILKSDGEPLRENTERRVSTSQHHPSQRTDDALDQDDENLRMAILESLQELNTNEEEEKEPEKHEHAAPNDKLSSKKSSKKKKKDKSKNRESSKDKSSKKSKSSSHSKKHAKDRNKEKQSKPTNNENTLDLSNILENLIHENDNAAIDTAKQTVDIQDNSHTDNTNNEDVEAQALVEATLKAFENELLSSAPTEEPSQEQSIGPVSSRKAVEPPRKPTADDIPLAMLQAFKPKKRPPQEKKKTKSKTSKAASTANKSPASESTSKKKKKKKTVKESNKSQEAYEDDEFSRILADMVNQVVNTSLKETSTHTATQDNKLESESDFTSPVQSQYTTEDASTANDDSLDLNQIMQNAMAMVFQNQNDDEFDENIVEDFNRGLGDLSVSDLLPHDNLSRMEKKSVPKSSSKSEKKTAISRRASKKASRDASSVELTEVPSKPKKPSKTEVSLEKKLRKKYVSIANEAASVARKKRWAKNKELKEKEKLERQTAREERRHKKKLEKQRLAEEQEELKKIVERGPPYPPDLRLTKSGKPKKPYRRWTPEELLKRSQEAEKPRKVKKERKKKEKKMKVPSSALKKIPLFNFVKGNVQPSARHRLNDIEGSLSTIGLHKSPDGVRRILSRPKSEDHEWPLSDSSASQNYDAHLKTVVHKEKIPFHPPWTIPSQPPFALPVARRKKIPNIKKYRKRTNNSFRVSKEGTASTRNRILPAILLPIINTLKAAAKSQTAAGATPEEARKRLATIIQHAKSTVIRAALQARKNSMQAAHSKGTTTELATTASRMKNPLKMIPIFNTSRVKQQLDKQLPARSAGTEISSSESPDKATPDPHSNSTIAGHTLKGVTTPIKIEDSDANVPPVSIAVSTIEPSQDKLELTKRAESVEPVENNVETAKETQSVQEIKENVGTKASEEVTLTEDKTNGDPKNEKRILIESPVEKTDKKKPGEKIATDLNEDASLSDKKDGDEKSTLHSDAAQLTGNEPDSVNTTTGKPKLIDVSLKPLNEAKPKIPIIFPLKRPQIKPEVSVINLVQNLVNTKIPEIKNESVDLGSNITDILSSTITNILPEITATDVKNYQYEDENVKYLKKTPRQVLNLDGLVPPSGRCITKAKRVRRIKKLSADATTAPEADGKANSESITYTFDIPSPEEVQSKRSVVLKFAKARLTEAELSCLKKEINNVRKRRWREMNSTKNWEYDVKSRLKKRANAFFGEGESETKSKWIEERFQEKVSQEKYKDRLETTETQANNTKIVIDDKEILNILAVNMNNLNKARCIEKDIQESFREEKLASLQPKKKRKKSILH
Protein: Large ribosomal subunit protein uL30B (60S ribosomal protein L7-B) (L6) (RP11) (YL8) (Q12213)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein eL8B
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL29A
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein uS15
Sequence:
MSTEKILTPESQLKKTKAQQKTAEQIAAERAARKAANKEKRAIILERNAAYQKEYETAERNIIQAKRDAKAAGSYYVEAQHKLVFVVRIKGINKIPPKPRKVLQLLRLTRINSGTFVKVTKATLELLKLIEPYVAYGYPSYSTIRQLVYKRGFGKINKQRVPLSDNAIIEANLGKYGILSIDDLIHEIITVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKHFIQGGSFGNREEFINKLVKAMN
Protein: Putative ankyrin repeat protein YahD (P77736)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Bis
- Uncharacterized protein YahJ
- Uncharacterized protein YahG
- Oxygen-dependent choline dehydrogenase
- Uncharacterized protein YahE
- Uncharacterized protein YnbD
- NADH-quinone oxidoreductase subunit C/D
- Uncharacterized protein YahF
- Protein InaA
- Uncharacterized protein YrbL
Sequence:
MSIKNLPADYLLAAQQGDIDKVKTCLALGVDINTCDRQGKTAITLASLYQQYACVQALIDAGADINKQDHTCLNPFLISCLNDDLTLLRIILPAKPDLNCVTRFGGVGLTPACEKGHLSIVKELLAHTEINVNQTNHVGWTPLLEAIVLNDGGIKQQAIVQLLLEHGASPHLTDKYGKTPLELARERGFEEIAQLLIAAGA
Protein: Uncharacterized protein C589.06c (Q9HDZ8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- DNA repair protein rad14
Sequence:
MNAQVLNLVAALGVMQYSKKLDFTDPQIVYYARAAYVISNTIIFGVYAIIQARINANNDETPLVYEEPAPPFSGQSNGKLVTTTVKEYDSEQLQKAKRSTMMGVAIMAFMHLYMGYAQPLVIQSILPLISLFTNNLVSIYIFNKAAEGSLSRPFAPPAGLFGGGNKPAAAVTGTSSNSNNASAKSDGPTITELNENETEKSS
Protein: Synaptic vesicle 2-related protein (SV2-related protein) (Q8N4V2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MEEDLFQLRQLPVVKFRRTGESARSEDDTASGEHEVQIEGVHVGLEAVELDDGAAVPKEFANPTDDTFMVEDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQEDRGKMRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQESSHREWGQEMVGRGMHGAGVTRSNSGSQE
Protein: Post-transcriptional regulator mkt1 (Inactive endonuclease mkt1) (Post-transcriptional RNA stability regulator mkt1) (Q9UTN2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in post-transcriptional regulation of gene expression by 3'-UTR-mediated RNA regulation. Promotes interactions between mRNA and poly(A)-binding protein. Binds the 3' UTR of mRNAs, centromeric transcripts and antisense-rDNA. Required for the establishment but not the maintenance of heterochromatin at pericentromeres, and for the maintenance of small domains of facultative heterochromatin known as HOODs.
Interaction partners:
- Ataxin-2 homolog
Sequence:
MTIRSLNLFIIDKKHQHKSSLSSFQNCKLGIDASFYLTQIIHSFTPQELQSLAVNGESEYLQHRISEFLEQLRTENITPIFVFNGIPLTFEASSQLEVPGKQKSHSALTDFEAFDPYDANIQRNMYRMDASGPANYGESKPTLLYTNQRDHLDRLCDQVKFYLDQCNVEYFVAPYLAMAQLAYFLNGTSSPYIDAIYGSTDLLLFGVKKFITSMNTSSNVKISSDPSSPSTQTTINSAAKSSFTWLDGNALLQDTNGLSWQQFIDSCLLCGTAISPTFPQIEGTFLIKSAMELVRMFGSAYRAVLHFAEIFPQPIFQDYLQQYKRAVCFSKFGIVMDTKGLTLPPVPTESVPNDINIYFGTRLPNEIYFYISRGLIPCKMIGALVSGCFSDPVSILEQHIGDKASQGTFSGANSGLNPGRDNAAAVAAVDQRRFVDDLEEIWSQGLNLLTQPLNRFYQARDIVSLHGHNQQASLKVMHSYDPPLYNDTRAWMIYEENLPSYLSSNFLKEEPVVLFDLLRALNDPVFVKKSFCTEGNIGIKNPPKHPLSSTAEIVLSSCYRFLQIRSFVLTSHQLTSWGCPLLKALENCHLQNQTSVVVLFELLRLRQLKEPSLLSSSSASIADLSITSATEFLAKVATFLPIKQRPEVSKISIVDENLLQFYQLQTSFGSNLKELMAMILASVILNRNVDKSKIDPKLIRKTLPFQNINGSLVSGFVVKRFFEIISKEQEASSQQENIQKAYEIIEKEFPTIGSAENHIAQFLEFWKTFMEGVKEAENTSAIGKLVLSKLFLTNQWIFSLGL
Protein: CCHC-type zinc finger nucleic acid binding protein (Cellular nucleic acid-binding protein) (CNBP) (Zinc finger protein 9) (P62634)
Organism: Rattus norvegicus (Rat)
Function: Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner. Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P53996}. Cytoplasm {ECO:0000250|UniProtKB:P62633}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P53996}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein K
- Muscleblind-like splicing regulator 1
Sequence:
MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA
Protein: SR-CI (Q5ELT4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MEFFWTLAVIVIYCIGHIHGRCERSIDLDNGSINYRQRNVVRFRCNRGYTLQGTVMQTCDRDGRLRGEKPFCASRGCARPEDPENGHVENLSLRADVVCHDGYVLVGGRTAYCDGERWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFSTTTEPTAPTGSNEQPLVYDMMSCSGRCGTSMSASNITNNGIVMGCGCNDECLSDETCCLNYLEECTKELLTTTEDDISSLPPTVTSTSTSTTRKSTTTTTTSTTTTSTTTTKRPTTTTTTTKATTTKRTTTTKKPTTTSTTPKPTTTTSTTPKSTTSTTSTTSTTPTTTTTINVFTTKKTTIMIPTSSTEKTTGINTTMKTRKRITWNVDPQDIEGHMDTSGSTPNPALVVLYLLLGIVLVVVLANVVNRWIIPITGSKTSSEKAVRFKKAFDSLKKQRKRNSMDDQPLCDSDNDDVEYFEEMGVDIRHRTDL
Protein: Fe(2+) transport protein 1 (Fe(II) transport protein 1) (Iron-regulated transporter 1) (Q38856)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High-affinity iron transporter that plays a key role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. Acts as the principal regulator of iron homeostasis in planta. Also mediates the heavy metals uptake under iron-deficiency by its ability to transport cobalt, cadmium, manganese and/or zinc ions.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12084823, ECO:0000269|PubMed:21628566, ECO:0000269|PubMed:24843126}; Multi-pass membrane protein {ECO:0000269|PubMed:12084823}. Early endosome {ECO:0000269|PubMed:21628566, ECO:0000269|PubMed:24843126}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:21628566, ECO:0000269|PubMed:24843126}. Vacuole {ECO:0000269|PubMed:21628566}. Note=Cycles constitutively between early endosomes and the plasma membrane and is targeted to the vacuole for degradation. {ECO:0000269|PubMed:21628566}.
Interaction partners:
- Ferric reduction oxidase 2
- Transcription factor ORG3
- Metal transporter Nramp3
- Transcription factor bHLH101
- Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
- Transcription factor ORG2
- Transcription factor bHLH100
- Transcription factor bHLH47
- Transcription factor MYB72
- Solute carrier family 40 member 2
Sequence:
MASNSALLMKTIFLVLIFVSFAISPATSTAPEECGSESANPCVNKAKALPLKVIAIFVILIASMIGVGAPLFSRNVSFLQPDGNIFTIIKCFASGIILGTGFMHVLPDSFEMLSSICLEENPWHKFPFSGFLAMLSGLITLAIDSMATSLYTSKNAVGIMPHGHGHGHGPANDVTLPIKEDDSSNAQLLRYRVIAMVLELGIIVHSVVIGLSLGATSDTCTIKGLIAALCFHQMFEGMGLGGCILQAEYTNMKKFVMAFFFAVTTPFGIALGIALSTVYQDNSPKALITVGLLNACSAGLLIYMALVDLLAAEFMGPKLQGSIKMQFKCLIAALLGCGGMSIIAKWA
Protein: BCL6 corepressor (H7BZ37)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLNINGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLYSPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTPSASPAIPPLVHCADKSLPWKMGVSPGNPVDSHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTYSEFHKHYARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDVDASKADHMKKMAPTVLVHSRAGSGLVLSGSEIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQRSSSCPRMGGTDAVITNVSGSVSSAGRPASASPAPNANADGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEPSFKANENGLPPSSIFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVVKSDKLVYVDLLREEPDAKTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALREELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPFLEPPLGSDGPAVTFGKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAYCERAMMRFSELEMKEREGGHPATKDSEMCKFSPADWERLKGNQDKKPKSVTLEEAIAEQNESERCEYSVGNKHRDPFEAPEDKDLPVEKYFVERQPVSEPPADQVASDMPHSPTLRVDRKRKVSGDSSHTETTAEEVPEDPLLKAKRRRVSKDDWPEREMTNSSSNHLEDPHYSELTNLKVCIELTGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSEESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRLCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDDAYSDVFEFEFSETPLLPCYNIQVSVAQG
Protein: Uncharacterized protein ycf70 (ORF89) (Q32759)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MVYGYGKSNMPHPNRKRKGTDTQYDYWEELLVMVSGLYVLFCVFLVLFIFFDSFKQESNKLELSGKEEKKKLNGENRLSRDIQNLLYIK
Protein: Procollagen galactosyltransferase 2 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 2) (ColGalT 2) (Glycosyltransferase 25 family member 2) (Hydroxylysine galactosyltransferase 2) (Q8IYK4)
Organism: Homo sapiens (Human)
Function: Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Interaction partners:
- Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
- Procollagen galactosyltransferase 1
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
- Collagen alpha-5
- Collagen alpha-2
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-2
Sequence:
MAARPAATLAWSLLLLSSALLREGCRARFVAERDSEDDGEEPVVFPESPLQSPTVLVAVLARNAAHTLPHFLGCLERLDYPKSRMAIWAATDHNVDNTTEIFREWLKNVQRLYHYVEWRPMDEPESYPDEIGPKHWPTSRFAHVMKLRQAALRTAREKWSDYILFIDVDNFLTNPQTLNLLIAENKTIVAPMLESRGLYSNFWCGITPKGFYKRTPDYVQIREWKRTGCFPVPMVHSTFLIDLRKEASDKLTFYPPHQDYTWTFDDIIVFAFSSRQAGIQMYLCNREHYGYLPIPLKPHQTLQEDIENLIHVQIEAMIDRPPMEPSQYVSVVPKYPDKMGFDEIFMINLKRRKDRRDRMLRTLYEQEIEVKIVEAVDGKALNTSQLKALNIEMLPGYRDPYSSRPLTRGEIGCFLSHYSVWKEVIDRELEKTLVIEDDVRFEHQFKKKLMKLMDNIDQAQLDWELIYIGRKRMQVKEPEKAVPNVANLVEADYSYWTLGYVISLEGAQKLVGANPFGKMLPVDEFLPVMYNKHPVAEYKEYYESRDLKAFSAEPLLIYPTHYTGQPGYLSDTETSTIWDNETVATDWDRTHAWKSRKQSRIYSNAKNTEALPPPTSLDTVPSRDEL
Protein: Splicing factor tls1 (Telomere length and silencing protein 1) (Q10148)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a role in pre-mRNA splicing by facilitating excision of introns featuring long spacing between the branchpoint and 3'-splice site. Assists the splicing of several components involved in chromatin organization, such as several shelterin complex subunits.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Pre-mRNA-splicing factor cwf14
Sequence:
MNSIHIKKKSNRSFRRRKVFGNEKEFDLEELDDNDIRLRQALEATKRRKIRNSIIGINAEKLLNQETKKEKQLNTANEPHEANDQTSAQSSKLIEAQLPTVEDRFAKQTNEVDINTHLLNFVEKKLKQERLAQNYSENGETNALNTKNESTVQNIKNSLHPNEHSFIRDAAALGAIREVDLGIISTDVDNLKNGRKRQKKRARMKEKLDSKALRTSEDAARDEFIEKMLKPISQDEESKGIYRRFRVYKDGTQD
Protein: Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) (P63025)
Organism: Rattus norvegicus (Rat)
Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Subcellular location: Early endosome membrane {ECO:0000250|UniProtKB:Q15836}; Single-pass type IV membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q15836}; Single-pass type IV membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q15836}.
Interaction partners:
- Synaptosomal-associated protein 23
- Syntaxin-4
- Syntaxin-3
- Syntaxin-2
- Syntaxin-16
- Vesicle transport through interaction with t-SNAREs homolog 1A
- Syntaxin-1B
- Syntaxin-6
- Alpha-soluble NSF attachment protein
- Syntaxin-1A
Sequence:
MSTGVPSGSSAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGISVLVIIVIIIIVWCVS
Protein: Candida glabrata strain CBS138 chromosome B complete sequence (Q6FXI6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Candida glabrata strain CBS138 chromosome E complete sequence
- Candida glabrata strain CBS138 chromosome L complete sequence
Sequence:
MVPHKYIVVLKKGVSPEAVATFLNDVSAAHAAAIRDLPKEHDFFNFVNAEGLPRGGIKDLFNINDLFQGLIGYFPEPVVKLLEKSDIVEFVERDSVVHASNFDTQNNAPWGLARISHRDRLNLGNFNKYLYDNAGGEGVTAYVIDTGINVKHVEFDGRAQWGKTIPLNDLDIDGNGHGTHCAGTIASKHYGIAKKANVVAVKVLKSDGSGTMSDVIKGVEYAAQAHLKESKNNKKFKGSTANMSLGGGKSPALDMAVNAAVSAGIHFAVAAGNENQDACNTSPASAEKAITVGASTLSDDRAYFSNWGKCVDIFAPGLNILSTYIGDTNRETASLSGTSMASPHVAGLLTYFLSLQPDSDSEFYDASKHGVTPAQLKKKLIAYSTKNVLTDLPDPDSPNLLIYNGAGGDLGVFWNSTSADEQSAEHPEQRIAAELGLDSLAKMVGDRHAATDSLFGQVRNLLDKMNII
Protein: Exocrine gland secreted peptide 23 (Exocrine gland-secreting peptide 23) (A8R0V5)
Organism: Mus musculus (Mouse)
Interaction partners:
- Odorant-binding protein 1a
Sequence:
MFVRSLLLLSVLTEGWVLPDPWKEPNTSVDHSTNVKRVVEKIVYKYITDQFEYNEQAFCEILDRLGVNVISRPLNVRKVNQLSFLKIMANSSSRCRNQKQIFTL
Protein: 24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.14.26) (Cytochrome P450 39A1) (hCYP39A1) (Oxysterol 7-alpha-hydroxylase) (Q9NYL5)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64654}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q64654}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cholesterol 24-hydroxylase
- 3 beta-hydroxysteroid dehydrogenase type 7
- Cholesterol 25-hydroxylase
- Bile acid receptor
- Lanosterol synthase
- Squalene monooxygenase
- Methylsterol monooxygenase 1
- Squalene synthase
Sequence:
MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI
Protein: 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) (Q99J99)
Organism: Mus musculus (Mouse)
Function: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P97532}. Mitochondrion {ECO:0000269|PubMed:18855522}. Synapse, synaptosome {ECO:0000269|PubMed:18855522}.
Interaction partners:
- Cystathionine gamma-lyase
- Sulfite oxidase, mitochondrial
- Persulfide dioxygenase ETHE1, mitochondrial
- Adenylyltransferase and sulfurtransferase MOCS3
- Cysteine desulfurase
- Cystathionine beta-synthase
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- Putative aspartate aminotransferase, cytoplasmic 2
- Thiosulfate sulfurtransferase
Sequence:
MAAPQLFRALVSAQWVAEALKAPRSSQPLKLLDASWYLPKLGRDARREFEERHIPGAAFFDIDRCSDHTSPYDHMLPNATHFADYAGSLGVSAATHVVIYDDSDQGLYSAPRVWWMFRAFGHHSVSLLDGGFRHWLNQNLPISSGKSHSEPAEFSAQLDPSFIKTHEDILENLDARRFQVVDARAAGRFQGTQPEPRDGIEPGHIPGSVNIPFTEFLTNEGLEKSPEEIKRLFKEKKVDLSKPLVATCGSGVTACHVVLGAFLCGKSDVPVYDGSWVEWYMRAQPEHIISEGRGKTQ
Protein: UPF0652 protein C16A11.03c (Q9USN2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MSIAQLFNQSWVEKSKYVPVRLSDEERKILSLLEAALEVIDYTGHVDIISYTTRTKLMVKYLNEMCSIVMGLVTAMDIKAGRDLLIGRDHKSNARFFQTVFEIGRRYKIMNPEKMRATYGAVMYMCQDSLIPDVRSQLGFDFVSPIKTVYNVLEKHKLLGLLEEKQLLNNLLKQSDPQSNANAKAELLKEREEASETLLKKYNPGKDEKLQKVLTDCFASLADHEAFLLANRNPVEKMRAYLHKFFNPHDTKNGSLKIGYMTGAKLNHDHKTQFFYVDQSLVFWSCMMDQMFLLWLESDASLLDKHSRYFISDTGQGLNRVQLCPLVRSTVTRILSSVQKQQEIPWMGSSVIHLGDRDVPNALMFIDKYRQVPHILAPLVKVLQQLEFLRDPYLVQYIENEYGSVNGLQKTILLDFFRHGFNGQGSDGGSCIDGRLTSAWNWTNEITKKKYYRILLMSGFLNFEGI