wanglab/gogpt-training-data huggingface dataset:
Protein: Disease resistance protein ADR2 (EC 3.2.2.6) (Protein ACTIVATED DISEASE RESISTANCE 2) (Protein WHITE RUST RESISTANCE 4) (Q9C7X0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TIR-NB-LRR receptor-like protein that confers broad-spectrum resistance and full immunity to several races of the pathogen Albugo candida (white rust disease). Confers resistance to the biotrophic pathogens Pseudomonas syringae pv. tomato DC3000 and Hyaloperonospora arabidopsis isolate Noco2. May play a role in the response to UV stress.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:18624640}.
Interaction partners:
- Disease resistance protein RPP8
- Probable disease resistance RPP8-like protein 4
- CCT motif family protein
- Putative U-box domain-containing protein 58
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- Wall-associated receptor kinase-like 22
- Bax inhibitor-1 family protein
- non-specific serine/threonine protein kinase
- Galactose oxidase/kelch repeat superfamily protein
- LRR protein
Sequence:
MASSSSSPRNWRYNVFTSFHGPDVRIKFLSHLRQQFVYNGITMFDDNGIERSQIIAPALKKAIGESRVAIVLLSKNYASSSWCLDELLEILKCKEYIGQIVMTVFYEVDPSHVRKQTGDFGIAFKETCAHKTEEERSKWSQALTYVGNIAGEDFIHWKDEAKMIEKIARDVSTKINVTPCRDFDDMVGLERHLKEMVSLLDLDKEGVKMVGISGPAGIGKSTIAKALHSRHSSTFQHNCFVDNLWENYKICTGEHGVKLRLHEQFVSKILKQNGLELTHLSVIKDRLQDKKVLIILDDVESLAQLETLADMTWFGPGSRVIVTTENKEILQQHGIGDIYQVGYPSESEALTIFCLSAFKQASPPDGFMDLADEVVRICDKLPLALCVLGSSLLRKSQTDWEDELPRLRNCLDGIESVLKVGFESLNEKDQALFLYITVFFNYECADHVTLMLAKSNLNVRLGLKNLANRYLIHIDHDQKKRVVVHRLLRVMAIQVCTKQKPWKSQILVDAEKIAYVLEEATGNRSIKGVSFDTAEIDELMISPKAFEKMCNLLFLKVYDAGWHTGKRKLDIPEDIKFPRTIRLFHWDAYSGKRLPSSFFAENLVEVNMQDSELQKLWEGTQCLANLKKIDLSRSSCLTELPDLSNATNLEDLYVGSCTALVELPSSIGNLHKLAHIMMYSCESLEVIPSLINLTSLTFLNMNKCSRLRRFPDIPTSIEDVQVTGTTLEELPASLTHCSGLQTIKISGSVNLKIFYTELPVSVSHINISNSGIEWITEDCIKGLHNLHDLCLSGCKRLVSLPELPRSLKILQADDCDSLESLNGHLNTPNAELYFANCFKLDAEARRAIIQQSFVSGWALLPGLEVPPEFGHRARGNSLIIPYSASNRFKVCVVMSLNHHQPFELVPRNLLYRWTVIGDSVSSDEKTFHLSHMFNADSVNSKLQKPHLFIFHSCLPFIFHSCLPFIFDISNIMLEFSSEYKDFDILECGVQILTDETDERNIWGSLVF
Protein: Myosin-2 (AtATM2) (AtMYOS1) (F4K0A6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables (By similarity). Involved in endocytosis via its action in endosomal trafficking.
Subcellular location: Cell junction, plasmodesma. Endosome.
Interaction partners:
- Protein ESSENTIAL FOR POTEXVIRUS ACCUMULATION 1
- Probable LRR receptor-like serine/threonine-protein kinase At1g07650
- Thioredoxin M3, chloroplastic
- Thioredoxin M1, chloroplastic
- B3 domain-containing protein At4g02870
- Late embryogenesis abundant protein M10
Sequence:
MMLSASPNTLAKSSLEEMLESLRQKDECDRPKDMPPALPSRPNSRARLPSARRSLPANFNVSSVMEDQNGSVVSVTPAVEAESERKEEGVKRKEKDLGVKRNSFGSKKMRTGLRSESPYAAEKEEEGVKISIAKVSLVENTEEHNKPESEWNNNVEYFIKKKLRVWCRVSNGQWQLGKIQSTSADTSLVMLSTANVVKVSTEELFPANPDILEGVEDLIQLSYLNEPSVLYNLRVRYLQDVIYSKAGPVLIAVNPFKNVEIYGNDVISAYQKKVMDAPHVYAVADAAYDEMMREEKNQSLIISGESGAGKTETAKFAMQYLAALGGGSCGVEYEILKTTCILEAFGNAKTSRNANSSRFGKLIEIHFSAMGKICGAKLETFLLEKSRVVQLFNGERSYHIFYELCAGASPILKERLKLKTASEYTYLSQSDCLTIAGVDDAQKFHKLLEAFDIVQIPKEHQERAFALLAAVLWLGNVSFRVTDNENHVEVVADEAVANAAMLMGCNTEELMVVLSTRKLQAGTDCIAKKLTLRQATDMRDGIAKFIYANLFDWLVEQINIALEVGKSRTGRSISILDIYGFESFKNNSFEQFCINYANERLQQHFNRHLFKLEQEEYEEDGIDWTKVEFVDNQECLDLIEKKPIGLLSLLDEESNFPKATDLTFANKLKQHLKTNSCFKGERGRAFRVNHYAGEVLYDTNGFLEKNRDPLPADLINLLSSCDCQLLKLFSTKMRGKSQKPLMLSDSTNQTVGTKFKGQLFKLMNKLENTSPHFIRCIKPNSKQLPRVYEEDLVLQQLRCCGVLEVVRISRSGYPTRLTHQEFAGRYGFLLSDKKVAQDPLSVSIAVLKQYDVHPEMYQVGYTKLYLRTGQIGIFEDRRKKVLQGIVGLQKHFRGHLSRAYFQNMRKVTLVLQSYIRGENARRLFDTEAKFHADSVSEASTDELSAVIHLQSAVRGWLARKHFNSMQRQKELRNVATKSKRKAGRRISEDKDIPLEQPQVQPTSMSDLQKRILKSEAALSQKEEENTALREQLRQFEERWSEYDIKMKSMEETWQKQMSSLQMSLAAARKSLAAESITGQAGGRQDTSISPFGYDSEDTMSTGTPGVRTPTNKFTNGNTPELRIRELNGSLNAVNHLAREFDQRRLNFDEDARAIVEVKLGPQATPNGQQQQHPEDEFRRLKLRFETWKKDYKARLRDTKARLHRVDGDKGRHRKWWGKRG
Protein: homocitrate synthase (EC 2.3.3.14) (Q59VG1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Aconitate hydratase, mitochondrial
- Acetyltransferase component of pyruvate dehydrogenase complex
- Acetyl-coenzyme A synthetase
- Acetyl-coenzyme A synthetase 2
- Acetyl-CoA acetyltransferase
- Malate synthase
- 2-isopropylmalate synthase
- Acetyl-CoA hydrolase
- homocitrate synthase
- Acetyl-CoA carboxylase
Sequence:
MVDGYKEVSESFDRSKIQHNPYGPNPGDFLSNVGNFQLIESTLREGEQFANAFFSTETKIEIAKALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDARVAVETGVDGVDVVIGTSQFLRQYSHGKDMNYIAQSAIEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYRTVDKIGVNRVGIADTVGCANPRQVYELVRTLKSVVKCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIAADREYVLSKYKVHKLRDIENLVAEAVQVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILSPSDFGLTRYIHFANRLTGWNAIKSRVDQLNLHLTDEQCKEVTNKIKKLGDVRQLNIDDVDSIIKDFHADMSTPLLKSNGAEEEPDVKKQKV
Protein: Ribosomal lysine N-methyltransferase 4 (EC 2.1.1.-) (SET domain-containing protein 7) (Q12504)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-55'.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ribosomal lysine N-methyltransferase 3
- Ribosomal lysine N-methyltransferase 2
- Ribosomal lysine N-methyltransferase 1
- Protein arginine N-methyltransferase 2
- Ribosomal lysine N-methyltransferase 5
- 20S-pre-rRNA D-site endonuclease NOB1
- Cytochrome c lysine N-methyltransferase 1
Sequence:
MDDFSRDTENFVCWLKTTAEIEVSPKIEIKDLCCDNQGRAVVATQKIKKDETLFKIPRSSVLSVTTSQLIKDYPSLKDKFLNETGSWEGLIICILYEMEVLQERSRWAPYFKVWNKPSDMNALIFWDDNELQLLKPSLVLERIGKKEAKEMHERIIKSIKQIGGEFSRVATSFEFDNFAYIASIILSYSFDLEMQDSSVNENEEEETSEEELENERYLKSMIPLADMLNADTSKCNANLTYDSNCLKMVALRDIEKNEQVYNIYGEHPNSELLRRYGYVEWDGSKYDFGEVLLENIVEALKETFETNTEFLDRCIDILRNNANIQEFLEGEEIVLDSYDCYNNGELLPQLILLVQILTILCQIPGLCKLDIKAMERQVERIVKKCLQLIEGARATTNCSATWKRCIMKRLADYPIKKCVSIEKPSKGNSLTREELRDVMARRVLKSEIDSLQVCEETIDKNYKVIPDEKLLTNILKRKLTEEEKSSVKRPCVKK
Protein: 56 kDa U1 small nuclear ribonucleoprotein component (Q03782)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-processing factor 39
- Small nuclear ribonucleoprotein-associated protein B
- Pre-mRNA-splicing factor RSE1
- U1 small nuclear ribonucleoprotein component PRP42
- Pre-mRNA-splicing factor PRP9
- Protein NAM8
- Protein LUC7
- Pre-mRNA-processing protein PRP40
- Nuclear cap-binding protein subunit 2
- U2 small nuclear ribonucleoprotein A'
Sequence:
MRPRRRGLAYHHTKPKGQLSQGHYPTTSNDGQRRKVGNSEAFQSFDIWKNLDRIRSTKKNAGQFIKGSLLILPMRTEDKQQFDECMDELHKYISKDILRCYPQKEQKDEGMLFYIVLKDFNILDSCFVLSVLLAFQKRLWMAPSEKSYFRVPKNINLTGSFYLPKNIETGRGHIITSYRREQPSSSIVEVGFNVVPDFQQFQVKACHVSKFMNELSNFFSQVEFGKCEANVINYFKREYNRTYSQISLALYELPLIGDGLFDIKSYISKTRPIIETSKAQMIKHISEMKAYNEISGLQGDQFPRQQRPLSNSPSSNSISSSQTIEAGATSYQTQPQRHAVNKPSNVLNSSNRHSGPKTFEDGRYSEGNKPGFMTQDEIKQHCIGTIKASMDAVKKKSSYQILKTYVRCPRQNYIDIVYQNLNDLRSKTNCNIVVLNLNNLHESQMWLESLNTTNYTIFAQAPHPSTIRVISIGGVGEYIVKALELILNILEH
Protein: Solute carrier family 25 member 19 (J3KSI7)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
Sequence:
MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPA
Protein: Cytochrome b-c1 complex subunit 10 (Q8MXI1)
Organism: Caenorhabditis elegans
Interaction partners:
- Cytochrome b-c1 complex subunit 6
- Cytochrome b-c1 complex subunit 8
- Complex III subunit 9
- Cytochrome b-c1 complex subunit 7
- Cytochrome b-c1 complex subunit 8
- Peptidase M16 N-terminal domain-containing protein
- Peptidase M16 N-terminal domain-containing protein
- Peptidase_M16 domain-containing protein
- Cytochrome c oxidase polypeptide VIIc
- CYtochrome P450 family
Sequence:
MLYMKPARFVKNAFTNPNYFKSYGAYGGSAFLLAIYFCEWKTVGQYIPLWNKRYVE
Protein: Cysteine proteinase inhibitor (Q7Y0Q9)
Organism: Saccharum officinarum (Sugarcane)
Interaction partners:
Sequence:
MAEAHNGRRVGMVGDVRDAPAGHENDLEAIELARFAVAEHNSKTNAMLEFERLVKVRHQVVAGTMHHFTVQVKEAGGGKKLYEAKVWEKVWENFKQLQSFQPVGDA
Protein: Naphthalene 1,2-dioxygenase/salicylate 5-hydroxylase systems, ferredoxin component (NDO/S5H systems ferredoxin component) (Ferredoxin NagAb) (O52381)
Organism: Ralstonia sp
Function: Component of two multicomponent enzyme systems which are involved in the catabolism of naphthalene. Plays a role as an electron transfer component for both salicylate 5-hydroxylase (S5H) and naphthalene 1,2-dioxygenase (NDO) systems, by transferring electrons to the oxygenase components.
Interaction partners:
Sequence:
MTQNWIDAACLDDIPEGDVVGVKVNGKEIALYEVEGEIYATDNLCTHGAARMSDGFLEGREIECPLHQGRFDVCTGKALCTPLTKDIKTYPVKIENMRVMLKME
Protein: CRS2-associated factor 2, chloroplastic (Chloroplastic group IIA intron splicing facilitator CRS2-associated factor 2) (Q84N48)
Organism: Zea mays (Maize)
Function: Required for the splicing of group IIB introns in chloroplasts. Forms splicing particles with CRS2. Interacts with RNA and confers intron specificity of the splicing particles.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:12881426}.
Interaction partners:
- Chloroplast RNA splicing2
- Chloroplastic group IIB intron splicing facilitator CRS2, chloroplastic
- Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic
- Ribonuclease III domain-containing protein RNC1, chloroplastic
- Protein WHAT'S THIS FACTOR 1
- Tha8
- Chloroplast RNA splicing1
- Transcription termination factor MTERF4, chloroplastic
- peptidyl-tRNA hydrolase
- CRM-domain containing factor CFM3, chloroplastic/mitochondrial
Sequence:
MPPPPPQRPASSHVGRANLFSASPPPLSNRRYPHHRSLPLPPVSPRRRDPKKHSQQPSQEEPTDSGPTRTVTTNPAFRAAHLRTAYRKPVPPAAAAGEGEALLAADPTDAASGRAVVVGPSGLSFRLPGAPFDFQFSYSEAPRAPPLAIREPAFLPFAPPTMPRPWTGKAPLLTKEEKARRRGVRLHTPLGQETPQTVSAHGIMMEVRERRKMDLARVSPGDGRSREEVLGEPLTPSEVRALVKPHISHNRQLNIGRDGLTHNMLEMIHCHWRRQEICKVRCRGVPTVDMKNLCYHLEEKSGGKVIHRVGGVVFLYRGRHYDPKTRPRYPLMLWKPATPVYPKLIKEAPDGFTKEEADEMRRKGRDLLPICKLAKNGIYITLVKDVRDAFEGSDLVKIDCEGLNPSDYKKIGAKLRDLVPCVLLSFDDEQILMHRGKEWKSRYSKPLTLIPKVPKNNLAMTSVMNSSDEVSDANTQVAIREVLRPKMFKLWKSAVDSSLALLLDDAEANNLTPDSLLTLVEEFSVTSQAVEHSFPALLVTNGDASTDSLSAEYMNDEPETSVAGNEEGQLEQSPDLRDDEHFDVDMFERLESSVPLGSLPIDSMIERLNSE
Protein: Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (O54949)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:21118996, ECO:0000269|PubMed:9448268}. Cytoplasm {ECO:0000269|PubMed:21118996}. Note=Predominantly nuclear. A smaller fraction is cytoplasmic. {ECO:0000269|PubMed:21118996}.
Interaction partners:
- Transcription factor 7-like 2
- Lymphoid enhancer-binding factor 1
- Transcription factor 7-like 1
- Transcription factor 7
- Mitogen-activated protein kinase kinase kinase 7
- Forkhead box protein O1
- Forkhead box protein O3
- Forkhead box protein O4
- Forkhead box protein O6
- Catenin beta-1
Sequence:
MSLCGTRANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
Protein: Polyadenylate-binding protein RBP47B' (Poly(A)-binding protein RBP47B') (RNA-binding protein 47B') (AtRBP47B prime) (AtRBP47B') (Q8VXZ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Heterogeneous nuclear ribonucleoprotein (hnRNP)-protein binding the poly(A) tail of mRNA and probably involved in some steps of pre-mRNA maturation.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasmic granule {ECO:0000250}.
Interaction partners:
- U1 small nuclear ribonucleoprotein A
- Tetratricopeptide repeat
- Probable small nuclear ribonucleoprotein F
- Sm protein F
- OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2
- Pre-mRNA-splicing factor 18
- THO complex subunit 4B
- At5g58020
- DGCR14-like protein
- 3-methyl-2-oxobutanoate hydroxymethyltransferase 1, mitochondrial
Sequence:
MAMMHPPQPPQGSYHHPQTLEEVRTLWIGDLQYWVDENYLTSCFSQTGELVSVKVIRNKITGQPEGYGFIEFISHAAAERTLQTYNGTQMPGTELTFRLNWASFGSGQKVDAGPDHSIFVGDLAPDVTDYLLQETFRVHYSSVRGAKVVTDPSTGRSKGYGFVKFAEESERNRAMAEMNGLYCSTRPMRISAATPKKNVGVQQQYVTKAVYPVTVPSAVAAPVQAYVAPPESDVTCTTISVANLDQNVTEEELKKAFSQLGEVIYVKIPATKGYGYVQFKTRPSAEEAVQRMQGQVIGQQAVRISWSKNPGQDGWVTQADPNQWNGYYGYGQGYDAYAYGATQDPSVYAYGGYGYPQYPQQGEGTQDISNSAAGGVAGAEQELYDPLATPDVDKLNAAYLSVHASAILGRPMWQRTSSLTSQLGK
Protein: (R)-phenyllactyl-CoA dehydratase beta subunit (EC 4.2.1.175) (Q93AL8)
Organism: Clostridium sporogenes
Function: Component of the phenyllactate dehydratase complex FldABC that is involved in the fermentation of L-phenylalanine via a Stickland reaction. This complex catalyzes the reversible syn-dehydration of (R)-phenyllactate to (E)-cinnamate in two steps, a CoA-transfer from cinnamoyl-CoA to phenyllactate, catalyzed by FldA, followed by the dehydration of phenyllactyl-CoA to cinnamoyl-CoA, catalyzed by FldB and FldC. Requires the activator FldI to initiate catalysis.
Interaction partners:
Sequence:
MSNSDKFFNDFKDIVENPKKYIMKHMEQTGQKAIGCMPLYTPEELVLAAGMFPVGVWGSNTELSKAKTYFPAFICSILQTTLENALNGEYDMLSGMMITNYCDSLKCMGQNFKLTVENIEFIPVTVPQNRKMEAGKEFLKSQYKMNIEQLEKISGNKITDESLEKAIEIYDEHRKVMNDFSMLASKYPGIITPTKRNYVMKSAYYMDKKEHTEKVRQLMDEIKAIEPKPFEGKRVITTGIIADSEDLLKILEENNIAIVGDDIAHESRQYRTLTPEANTPMDRLAEQFANRECSTLYDPEKKRGQYIVEMAKERKADGIIFFMTKFCDPEEYDYPQMKKDFEEAGIPHVLIETDMQMKNYEQARTAIQAFSETL
Protein: Trichodiene synthase (EC 4.2.3.6) (Sesquiterpene cyclase) (TS) (Q00909)
Organism: Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)
Function: TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
Interaction partners:
- Squalene synthase ERG9
- Farnesyl pyrophosphate synthase ERG20
- Geranylgeranyl pyrophosphate synthase dpfgD
- Chromosome 3, complete genome
- Chromosome 1, complete genome
- ditrans,polycis-polyprenyl diphosphate synthase [
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Alkyl transferase
Sequence:
MENFPTEYFLNTSVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPRQQQMLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDDSSDDPHPAMLNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLIRSTMDFFEGCWIEQYNFGGFPGSDDYPQFLRRMNGLGHCVGASLWPKDLFDERKHFLEITSAVAQMENWMVWVNDLMSFYKEFDDERDQISLVKNFVTCHEITLDEALEKLTQETLHSSKQMVAVFSDKDPQVMDTIECFMHGYVTWHLCDARYRLHEIYEKVKDQDTEDAKKFCKFFEQAANVGAVAPSEWAYPQVAQLANVRAKDDVKEAQKPILSSIELVE
Protein: Protein SOSEKI 1 (PpSOK1) (A0A2K1JJ00)
Organism: Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens)
Function: SOSEKI proteins locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9SYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9SYJ8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9SYJ8}.
Interaction partners:
Sequence:
MAFEENFLSAQVLYQLSWNGKLEHPHIIDVEYASDQGGLRLRDVKERLTRLRGHGINDSFSWSYKRTYSKTFIWNDLSDDDVIHPLCGSGEYVLRASELIDTNERKSCDVHSRHSNKSMQSSPTMLLDNVTSKQDTIIGDVHFGALESGENRRIGDKLNCLVRNSGANLEEVKSLRGVSAVISQSLPTLYADQEIMDVEKSDFCLSSSDTEISPRPKMTVDSIKPVKDVNLVVMTKSSTVHGVHTPPSPSLKSSTELPFSPGGTKRLWEKEIRKSLFRTRNSSNVNSVSTEDFTAVHMELPPNTHSTHEDNSFWRDSRSKSPSPSSLNELKEVQIDKEEVEQSTSQLIRLLWARWTGGSSKGKRIPYNTCEGASTKIPESKHNSPYRTKSPYKEIRSTHVEGSHQETRQSLAVQSKARVSLEIKEILPPEECMHYPSPMTVQNVTEVASPHAQTDGGGDVCTIKTIVSEQASQPYPEPRDLRTDQGILSEKTPGLHIAVLEGLTSDAPSGPAEAEVDTPLPAVARAKTGNTLSKLKTIASSKPLPPGFHKGTNDTKPVQITPRRTPRNSIPLASPPLVRSFSRDAVRGFSSLAAISLCPDKDSVACTPSPEKTIVKKRINYSAREEMPLVPGLTTLDWEKALQEATTDCLPPPNFSDILQECSICRRTFKPDSLQVHMRGCHPPQYARAFSARASPHVVRC
Protein: Probable sulfatase (Q6MX51)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Trehalose 2-sulfotransferase
- D-3-phosphoglycerate dehydrogenase
- Formylglycine-generating enzyme
Sequence:
MTSERATGQRENLLIVHWHDLGRYLGVYHHPDVYSPRLDRLAAEGILFTRAHATAPLCTPSRGSLFTGRYPQSNGLVGLAHHGWEYRTGVQTLPQLLSESGWYSALFGMQHETSYPKRLGFDEFDVSNSYCEYVVAKAQDWLHNRVPALDGQRFLLTAGFFETHRPYPHERYRPADSAAVELPDYLPDTPEVRQDVAEFYGSIATADEAVGRLLDTLADTGLDASTWVVFVTDHGPAFPRAKSTLYDAGTGIALIIRPPTRRAMAPRVYDELFSGVDLVPTLLDLLRLEVPADVEGVSHAPALLAPDTENAAVRDHVYTAKTYHDSFDPIRAIRTKEYSYIENYAPRPLLDLPWDIQESPAGMAVAPLVKAPRPQRELYDLRADPTETNNLLAGDDSTQGVAAIAADLAVRLHDWRQRTADVIPSDFAGSRIAERYTETYLRIHRKTPTGRSAIAADRGIDEHCS
Protein: CAP, isoform W (A0A0B4KEJ6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDKVRELIEMTRREQEQGELPRSPSPPPVPPPPASVPPYSPESSSFHLASLQLKRQESNDSHCSDSTTHSQCTAINLASPPPPPTAQPPTPPLRQKPAPPPVPQPVSPPAPPTPQSEPELSVADSVANANADVDADADTDTEAIKKLRLLCTEQLASMPYGEQVLEELASVAQNISDQSQNKMPYPMPQLPHIKELQLNANESKSSSAWLGLPTQSDPKLLVCLSPGQRDLVNNQTQPDDLLDAHQKFVERRGYHELSKAQVLEQDHQQQQSEMLKTAAMMRELRKSLSPPAPPVPPPPVPVKSAETAAKATAHENAKRDDASEQKQKIAACESSSLENKPRRAADLGAQQSAEQRQSSSTTTSSHKATTETMSSDTAKFPTLDSMESELARMFPQHKGDIFEEQRKRFSNIEFPSHQPVSQTKRYSNIETSSYESKKRMENGQVVYDVSTSSHEKKEQGDPPKDQPVPPVPPPPIMSATKLNGNTFIDGDVAPKNSQPSRESGSGSGNGTYEEFRQRAKAAADAFGEQREQQNGLDQDRVFKDFDRLSQQMHAELQSTREKREKSASMYDLSGFTRPASGHPRLDELQQRRHAHMQELEREIERSAKSRQERMSSVPRQMEATPPRTHEIPIELEPRSRRAESLCNLNEPPPRPHTTVGHYNHPVVQDDWSRYANDLGYSENIARPFAREVEICYQRQNQRTPHCIRAPRLSASTNDLSSSSQYSYDTFNAYGGRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSRRGVSPAPPPVATPQQQQVPPPAYDRQQRRSSLPRELHEQQLKYILSKEEELKFEVERLQQERRRLMEEMQRAPVLPAPQRRESYRPAAKLPTLSEDEVFRQQMAEEWMNKVAEREERRQHKIIRISKIEDEHDHSAVDKATISDEFLDRVKERRHKLSMPADSDWESGAESQPQPAAQSQPESDVEAPPVRILEGQAEANLRQLPRHLREFAKFSTSEQLPDGAQMERHEEQERREEATDNAHSSATKKTSIVKTYKVSRLPPSVQARPSYKSNGYVSEPEPNYDSDYSTVRYRTQNPHRVQSVSSAVNVRNLNQDEKLYGTMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKENLEQSKLSPLYTEGNLSRALAKESGYTSDSNLVFRKKEVPVSSPLSPVEQKQAYKSLQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVKGLSSYDFPYSTDTVDGSDVNIHFKTPIRHEQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSKRPSEGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKIANRKGIFPCSYVEVLTDIGAEDIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKTDALHVDTSSEPLAYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVERA
Protein: DNA-directed RNA polymerase II subunit RPB2 (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (EC 2.7.7.6) (DNA-directed RNA polymerase II 138 kDa polypeptide) (Q02061)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerase II subunit rpb4
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit rpb1
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MSYEDYQYNETLTQEDCWTVISSFFEETSLARQQLFSFDEFVQNTMQEIVDDDSTLTLDQYAQHTGAQGDVTRRYEINFGQIYLSRPTMTEADGSTTTMFPQEARLRNLTYSSPLYVDMRKKVMVAADSNVPIGEEEWLVEEEDEEPSKVFIGKIPIMLRSTFCILNGVSDSELYDLNECPYDQGGYFIINGSEKVIIAQERSAANIVQVFKKAAPSPIAYVAEIRSALERGSRLISSMQIKLMARNTENSGQTIRATLPYIRSDIPIVIVFRALGVVPDRDILEHICYDPNDFQMLEMMKPCIEEAFVIQDKDIALDYIGKRGSTTGVTREKRLRYAHDILQKELLPHITTMEGFETRKAFFLGYMIHRMLLCALERREPDDRDHFGKKRLDLAGPLLASLFRMLFRKMTRDVYKYMQKCVETNREFNLTLAVKSNIITNGLRYSLATGNWGDQKRSMVNRVGVSQVLNRYTFASTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGMVCPAETPEGQACGLVKNLSLMSYVSVGSPSAPIIEFLEEWGLETLEDYNPSASPNATKVFVNGVWLGVHRDPAHLTETLRSLRRRLDISAEVSIVRDIREKELRLFTDAGRICRPLFIVDNNPNSERRGELCIRKEHIQQLIEDKDRYDIDPEQRFGWTALVSSGLIEYLDAEEEETVMIAMSPEDLEASRQMQAGYEVKEELDPAQRVKPAPNPHVHAWTHCEIHPAMILGILASIIPFPDHNQSPRNTYQSAMGKQAMGVYLTNYQVRMDTMANILYYPQKPLATTRSMEYLKFRELPAGQNAIVAILCYSGYNQEDSIIMNQASIDRGLFRSIFYRTYTDQEKKIGMTVMEEFERPVRSTTLRMKHGTYDKLEDDGLIAPGTRVSGEDIIIGKTAPIPLDHEELGQRTQLHAKRDVSTPLRSTESGIVDQVMVTTNQEGLKFVKVRMRSTRIPQIGDKFASRHGQKGTIGMTYRHEDMPFSAQGIVPDIIINPHAIPSRMTVAHLVECQLSKVSALSGFEGDATPFTDVTVEAVSKLLRSHGFQSRGFEVMYHGHTGRKLVAQVFLGPTYYQRLKHLVDDKIHARARGPVQILTRQPVEGRSRDGGLRFGEMERDCQISHGCSSVLRERLFDCSDAYRVIVCDICGLIAIASYKKDSYECRSCQNRTRFSQVYLPYAAKLLFQELMSMNIAPRLFTKNHK