wanglab/gogpt-training-data huggingface dataset:
Protein: 3-hydroxykynurenine transaminase (EC 2.6.1.63) (AgHKT) (Alanine--glyoxylate aminotransferase) (EC 2.6.1.44) (Q7PRG3)
Organism: Anopheles gambiae (African malaria mosquito)
Function: Catalyzes the pyridoxal 5'-phosphate-dependent transamination of both 3-hydroxykynurenine and L-kynurenine to xanthurenic acid and kynurenic acid, respectively, preferentially using the alpha-ketoacid glyoxylate as the amino group acceptor. Although glyoxylate is the preferred amino group acceptor, transamination of 3-hydroxykynurenine also works with pyruvate as the amino acceptor in vitro. Involved in the detoxification of cytotoxic metabolite 3-hydroxykynurenine generated by the hydroxylation of L-kynurenine, an intermediate in the tryptophan catabolism pathway. The Plasmodium parasite uses xanthurenic acid produced in the midgut to activate its gametocytes ingested during a blood meal (Probable). Also catalyzes, although with a lesser efficiency, the transamination of alanine with glyoxylate as an amino group acceptor (By similarity). May play a role in the detoxification of glyoxylate, a toxic plant metabolite from the diet (By similarity).
Subcellular location: Peroxisome {ECO:0000250|UniProtKB:P21549}.
Interaction partners:
- Serine hydroxymethyltransferase
- Phosphoserine phosphatase
- AGAP003688-PA
- AGAP013274-PA
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Glyoxylate reductase/hydroxypyruvate reductase
- Glyoxylate reductase/hydroxypyruvate reductase
- AGAP009611-PA
- Glyoxylate reductase/hydroxypyruvate reductase
- (S)-2-hydroxy-acid oxidase
Sequence:
MKFTPPPASLRNPLIIPEKIMMGPGPSNCSKRVLTAMTNTVLSNFHAELFRTMDEVKDGLRYIFQTENRATMCVSGSAHAGMEAMLSNLLEEGDRVLIAVNGIWAERAVEMSERYGADVRTIEGPPDRPFSLETLARAIELHQPKCLFLTHGDSSSGLLQPLEGVGQICHQHDCLLIVDAVASLCGVPFYMDKWEIDAVYTGAQKVLGAPPGITPISISPKALDVIRNRRTKSKVFYWDLLLLGNYWGCYDEPKRYHHTVASNLIFALREALAQIAEEGLENQIKRRIECAQILYEGLGKMGLDIFVKDPRHRLPTVTGIMIPKGVDWWKVSQYAMNNFSLEVQGGLGPTFGKAWRVGIMGECSTVQKIQFYLYGFKESLKATHPDYIFEESNGFH
Protein: Glutathione S-transferase theta-2 (EC 2.5.1.18) (GST class-theta-2) (P0CG29)
Organism: Homo sapiens (Human)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:1417752}. Nucleus {ECO:0000250|UniProtKB:P30713}.
Interaction partners:
Sequence:
MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDGDFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLGPLIGVQVPKEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALGYELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRIARIP
Protein: Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A) (O43301)
Organism: Homo sapiens (Human)
Function: Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8K0U4}. Nucleus {ECO:0000250|UniProtKB:Q8K0U4}.
Interaction partners:
- Heat shock 70 kDa protein 1A
- Heat shock 70 kDa protein 4
- Endoplasmic reticulum chaperone BiP
- Heat shock 70 kDa protein 12B
- Heat shock 70 kDa protein 13
- Heat shock cognate 71 kDa protein
- Heat shock 70 kDa protein 4L
- Heat shock 70 kDa protein 14
- A-kinase anchor protein 12
- Stress-70 protein, mitochondrial
Sequence:
MADKEAGGSDGPRETAPTSAYSSPARSLGDTGITPLSPSHIVNDTDSNVSEQQSFLVVVAVDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSNQKTPTTILLTPERKFHSFGYAARDFYHDLDPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKALEIFAYALQYFKEQALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQAGLASPENSEQLIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRTFLVENVIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFEKLLYKIFGEDFIEQFKIKRPAAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGGFAEAPLLQQAVQAAFGDQCRIIIPQDVGLTILKGAVLFGLDPAVIKVRRSPLTYGVGVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIVINIYSSEHDNVSFITDPGVKKCGTLRLDLTGTSGTAVPARREIQTLMQFGDTEIKATAIDIATSKSVKVGIDFLNY
Protein: Guanylyl cyclase-activating protein 2 (Guanylate cyclase activator 1B) (Q90WX3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGQRLSDDSDEKEIDVAELQEWYKKFVIECPSGTLFMHDFKSFFGVTENPEAADYIENMFRAFDKNGDNTIDFLEYVAALNLVLRGKLEHKLKWTFKMYDKDGSGCIDKTELKEIVESIYRLKKACHGELDAECNLLTPDQVVDRIFELVDENGDGELSLDEFIDGARRDKWVMKMLQMDVNPGDWINEQRRRSANF
Protein: Flagellar hook-associated protein 2 (HAP2) (Filament cap protein) (Flagellar cap protein) (P39738)
Organism: Bacillus subtilis (strain 168)
Function: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
Subcellular location: Secreted. Bacterial flagellum.
Interaction partners:
- Flagellar protein FliT
- Flagellar motor switch phosphatase FliY
- Uncharacterized protein YvyC
- Flagellar hook-associated protein 3
- Flagellar secretion chaperone FliS
- Flagellin
- Flagellar hook-associated protein 1
- Flagellar motor switch protein FliM
- Flagellar motor switch protein FliG
- Flagellum-specific ATP synthase
Sequence:
MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRDSYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVASLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSSDLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNKLTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYNQIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRNDSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAEDPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNLNSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ
Protein: LexA repressor (EC 3.4.21.88) (Q8UFK2)
Organism: Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Interaction partners:
- Protein RecA
- DNA polymerase IV 1
- DNA repair protein RecN
- Uncharacterized protein
Sequence:
MLTRKQQELLLFIHERMKESGVPPSFDEMKDALDLASKSGIHRLITALEERGFIRRLPNRARALEVIKLPEAYTPGARPQRGFSPSVIEGSLGKPKEPEPAPAVKAPANDFAGAATIPVMGRIAAGVPISAIQNNTHDLAVPVDMLGSGEHYALEVKGDSMIEAGIFDGDTVIIRNGNTANPGDIVVALVDDEEATLKRFRRKGASIALEAANPAYETRIFGPDRVKIQGKLVGLIRRYH
Protein: Syntaxin-4 (Renal carcinoma antigen NY-REN-31) (Q12846)
Organism: Homo sapiens (Human)
Function: Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q08850}; Single-pass type IV membrane protein {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q08850}. Cell projection, stereocilium {ECO:0000250|UniProtKB:P70452}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000250|UniProtKB:Q08850}.
Interaction partners:
- Synaptosomal-associated protein 23
- Vesicle-associated membrane protein 8
- Vesicle-associated membrane protein 7
- Syntaxin-binding protein 3
- Vesicle-trafficking protein SEC22b
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 2
- Syntaxin-6
- Synaptosomal-associated protein 25
- Vesicle-associated membrane protein 4
Sequence:
MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG
Protein: CBK1 kinase activator protein MOB2 (MPS1 binder 2) (Maintenance of ploidy protein MOB2) (P43563)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation.
Subcellular location: Nucleus. Cytoplasm. Note=Localizes to the bud cortex during polarized growth and to the bud neck and daughter cell nucleus during late mitosis.
Interaction partners:
- Serine/threonine-protein kinase CBK1
- Serine/threonine-protein kinase KIC1
- Protein HYM1
- Leucine-rich repeat-containing protein SOG2
- Metallothionein expression activator
- Cell morphogenesis protein PAG1
- Cell cycle protein kinase DBF2
- Serine/threonine-protein kinase DBF20
- Endochitinase
Sequence:
MSFFNFKAFGRNSKKNKNQPLNVAQPPAMNTIYSSPHSSNSRLSLRNKHHSPKRHSQTSFPAQKSTPQSQQLTSTTPQSQQQEASERSESQQIMFLSEPFVRTALVKGSFKTIVQLPKYVDLGEWIALNVFEFFTNLNQFYGVVAEYVTPDAYPTMNAGPHTDYLWLDANNRQVSLPASQYIDLALTWINNKVNDKNLFPTKNGLPFPQQFSRDVQRIMVQMFRIFAHIYHHHFDKIVHLSLEAHWNSFFSHFISFAKEFKIIDRKEMAPLLPLIESFEKQGKIIYN
Protein: Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161) (Zfp-161) (Zinc finger protein 5) (ZF5) (Q08376)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene (By similarity). Transcriptional repressor of MYC and thymidine kinase promoters.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDESNGQSKSKYCLKLNRPIGDAADAQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS
Protein: Monofunctional chorismate mutase (EC 5.4.99.5) (CM-F) (P42517)
Organism: Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate. May sequester with cyclohexadienyl dehydratase and an aromatic aminotransferase to form phenylalanine or phenylpyruvate.
Subcellular location: Periplasm {ECO:0000269|PubMed:8335631}.
Interaction partners:
Sequence:
MTHFVAIFFSSLFMCSNVFAGSVSSVSLGSLSSALNERMQVMKAVAGYKALHHLPIEDLPREQVVLDHMLQNAQQAGLEPHSVEPFVHALMNASKTIQYRYRADWLSSPDSAVPVRDLTETRQQIQQLDTQLLTAISQRLMTGAFSQEDKEFLMSHLTAPHLSESDKNSLFASLSRIQRQH
Protein: Vacuolar membrane-associated protein iml1 (O74788)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Vacuole membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Nitrogen permease regulator 3-like protein
- Uncharacterized WD repeat-containing protein C12G12.01c
- Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05
- Nitrogen permease regulator 2 homolog
- Uncharacterized WD repeat-containing protein C4F8.11
- Protein transport protein sec13
- Nucleoporin seh1
- GTP-binding protein gtr1
- GTP-binding protein gtr2
- Mitochondrial inner membrane protease subunit 1
Sequence:
MAITLNLWTHESSLFPNDAVLNYDLVPSAKPGDIFEIRAQNGDEIALQHNHSSTGKLHAKREKEPVYLMPSPLTDDLKRRHPNLQLSVVSHISSLLNIKNREPVVVKICEDKTNLEAEHVVIFFRDQFISRSDMWKLFRELCGKCVYLKQRVSFIGDVPGEIRCIWRKGKKCHSAYISERTKPIFRSESARFLIFIQMSEEMWHFEEDGELNYNKAIDGFLPDLFSFWRDLGTHHLVSIILFTRVEYSHHGPMCVWQPRSQKNSEKGSSIYPQNSFNASIDNEGGPYEDFFKVVVDNVSSRDWQPVLANLKLELAKFRQDVIVRKIKDENGREIEYICGRMTGSQEGNFLEVINMAVFQFQSDYIDRDLSRTGTSIIIVTPGTGLYEVNEKMLHLTSKSLLNTVVGMDIVSLGKVPLFLTPIVRYKNPVKNKKRSQLTSRISSSVSPSNVIPNSLTSSVSNFSVSSFLNNLKEDTEWLYTFPIGCNISFYSTTEMRSLRSPWENLMREHQFEPTAKMHELQMMGVLEAESAKISIPLLQSDPLLKGSVFSEEVQEDYDERQFTGEAAVSANDVLSSSSPRHFSSHTPVNVDKSSYLEMNGHSLSTVISGKESISSFGAKVDDLKSTSKESARQFGKSALTERLQKLAGNSSNVSSSLQTSSSNKSSLLTKKSSFPALLKGFLALPATVTTSANPLGFKSTIQRPIPIKNNEDSDSCKAFSQAPPIATKKPPTFLKPNSPEYAKTVIPKSSTNLENEYQTPWKIIQNPFKLKETTADNDPVSLRWEHLYMKVQDVRKFNWLSMCTPGALPLTFSYFPSEEELNDKFEEYTYTIGIDPEFTQMNQQELLAEMICQRLSRGYQIVVNPAAAVSYSGNPKANKAGTITDFSRSVNNQRNGHLTVGSDAVCLSLGDSQFHRLSCDSVGYNIEVKRYVKKVSGQGKMRYDYNFWSKNECKYVKSNITFSANDSANYNWNYVDQLICGFETYLPDSVKYWRARFVLLPMSTTSTHVFQKYQLLDHADALSDEEFRVEGIYKLSELLYKGKIDPMNDSNNKTPNTSPAELLGIKFTTLPMAQYIHSELEALRLDSSRNEQSLFMPNKRLDCSADLHTIAKEIQGPGGPKIDDITWHYRIYENCFLGSEFVSWLANTFIGINTREEALKYGNKLLSLGLFDHALKKHPLLDGYYVYRISPDYSIKPVSNRPYRSWFSRKKDSGQKHLDNKIITESEAGPSRLELSRRILFNADVEKKNGKSETVTVHYDLLHNPASCYHIRIEWLLATASVIEKLLQSWSRILERYGLKLVEAPIHEIAAVGELNPFDQVSIISLALDPPPIPERAPLVNDPVNYSKNWWNVKILEHFDFILDTEAASTFPKSITAVYSWGKPNFRYVQYIHRTGTVLVQIDDDQRFLWLPNRLHNSKVSKLSFTKSNKSTLNPNLKETAEELERKFREFCSNKDELDQFYGIVNHASDDRRSIYSSASTHASNASADDASNVNV
Protein: Tol-Pal system protein TolR (P0ABV6)
Organism: Escherichia coli (strain K12)
Function: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. The Tol-Pal system is also required for polar localization of chemoreceptors clusters. The system also appears to be required for the activity of several outer membrane-localized enzymes with cell wall remodeling activity. Modeling suggests that non-covalent binding of OmpA (from the outer membrane) and TolR (from the inner membrane) to peptidoglycan maintains the position of the cell wall in the periplasm, holding it approximately equidistant from both the inner and outer membranes. Trimeric Lpp controls the width of the periplasm, adjusts its tilt angle to accommodate to the available space, and can compensate in part for an absence of OmpA (Probable).
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02203, ECO:0000269|PubMed:8331075, ECO:0000269|PubMed:8376353}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02203, ECO:0000269|PubMed:8376353, ECO:0000305|PubMed:8331075}. Note=Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity. {ECO:0000269|PubMed:17233825}.
Interaction partners:
- Tol-Pal system protein TolQ
- Tol-Pal system protein TolB
- Tol-Pal system protein TolA
- Peptidoglycan-associated lipoprotein
- Acyl-CoA thioester hydrolase YbgC
- Biopolymer transport protein ExbB
- Cell division coordinator CpoB
- Motility protein B
- Protein TonB
- Outer membrane protein A
Sequence:
MARARGRGRRDLKSEINIVPLLDVLLVLLLIFMATAPIITQSVEVDLPDATESQAVSSNDNPPVIVEVSGIGQYTVVVEKDRLERLPPEQVVAEVSSRFKANPKTVFLIGGAKDVPYDEIIKALNLLHSAGVKSVGLMTQPI
Protein: Small ribosomal subunit protein mS86 (rPPR1) (Pentatricopeptide repeat-containing protein At1g61870, mitochondrial) (Protein PENTATRICOPEPTIDE REPEAT 336) (Q8LE47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in translation through its association with polysomes. Could bind RNA.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:15269332, ECO:0000269|PubMed:18054044}.
Interaction partners:
- At5g03450
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS11m
- Pentatricopeptide repeat-containing protein At3g02490
- Pentatricopeptide repeat-containing protein At1g15480
- DEAD-box ATP-dependent RNA helicase 32
- Small ribosomal subunit protein mS77
- Pentatricopeptide repeat-containing protein At1g26460
- E3 ubiquitin-protein ligase makorin
- At4g13070
Sequence:
MALLSRIRSSTSLFRHLNASPQIRSLSSASTILSPDSKTPLTSKEKSKAALSLLKSEKDPDRILEICRAASLTPDCRIDRIAFSAAVENLAEKKHFSAVSNLLDGFIENRPDLKSERFAAHAIVLYAQANMLDHSLRVFRDLEKFEISRTVKSLNALLFACLVAKDYKEAKRVYIEMPKMYGIEPDLETYNRMIKVFCESGSASSSYSIVAEMERKGIKPNSSSFGLMISGFYAEDKSDEVGKVLAMMKDRGVNIGVSTYNIRIQSLCKRKKSKEAKALLDGMLSAGMKPNTVTYSHLIHGFCNEDDFEEAKKLFKIMVNRGCKPDSECYFTLIYYLCKGGDFETALSLCKESMEKNWVPSFSIMKSLVNGLAKDSKVEEAKELIGQVKEKFTRNVELWNEVEAALPQ
Protein: Hepatocyte nuclear factor 4 gamma (F1D8Q4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MDMANYSEVLDPTYTTLEFETMQILYNSSDSSAPETSMNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMSTLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL
Protein: Transcription elongation factor GreA (Transcript cleavage factor GreA) (P9WMT9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
Interaction partners:
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit beta
- DNA-directed RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit omega
- Transcription termination/antitermination protein NusG
- Transcription termination factor Rho
Sequence:
MTDTQVTWLTQESHDRLKAELDQLIANRPVIAAEINDRREEGDLRENGGYHAAREEQGQQEARIRQLQDLLSNAKVGEAPKQSGVALPGSVVKVYYNGDKSDSETFLIATRQEGVSDGKLEVYSPNSPLGGALIDAKVGETRSYTVPNGSTVSVTLVSAEPYHS
Protein: Zinc finger protein CONSTANS-LIKE 2 (Q96502)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcription factor. Does not affect flowering time.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein CCA1
- Protein LHY
- Protein GIGANTEA
- Cyclic dof factor 1
- AT3g20370/MQC12_13
- Adagio protein 3
- MADS-box protein SOC1
Sequence:
MLKEESNESGTWARACDTCRSAACTVYCEADSAYLCTTCDARVHAANRVASRHERVRVCQSCESAPAAFLCKADAASLCTACDAEIHSANPLARRHQRVPILPLSANSCSSMAPSETDADNDEDDREVASWLLPNPGKNIGNQNNGFLFGVEYLDLVDYSSSMDNQFEDNQYTHYQRSFGGDGVVPLQVEESTSHLQQSQQNFQLGINYGFSSGAHYNNNSLKDLNHSASVSSMDISVVPESTASDITVQHPRTTKETIDQLSGPPTQVVQQLTPMEREARVLRYREKKKTRKFDKTIRYASRKAYAEIRPRIKGRFAKRIETEAEAEEIFSTSLMSETGYGIVPSF
Protein: Small ribosomal subunit protein eS8 (40S ribosomal protein S8) (Q08069)
Organism: Zea mays (Maize)
Interaction partners:
- 40S ribosomal protein S17-1
- 40S ribosomal protein S15
- 40S ribosomal protein S19
- 40S ribosomal protein S19
- Small ribosomal subunit protein uS17
- 40S ribosomal protein S11-1
- Small ribosomal subunit protein eS28
- 40S ribosomal protein S28
- 40S ribosomal protein S12
- 40S ribosomal protein S12
Sequence:
MGISRDSMHKRRATGGKQKAWRKKRKYELGRQPANTKLSSNKTVRRVRVRGGNVKWRALRLDTGNYSWGSEAVTRKTRILDVVYNASNNELVRTQTLVKSAIVQVDAAPFKQWYLTHYGVDIGRKKKTPAAKKDNAEGQEVEAAAEETKKSNHVTRKLEKRKEGRTLDPHIEEQFGSGRLLACISSRPGQCGRADGYILEGKELEFYMKKLQRKKGKSAVA
Protein: Ataxin 3 (G3V3T6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQ
Protein: Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Dsps2) (Selenophosphate synthase 2) (Q9VKY8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Synthesizes selenophosphate from selenide and ATP.
Interaction partners:
- O-phosphoseryl-tRNA
- tRNA selenocysteine-associated protein 1
- Thioredoxin reductase 2, mitochondrial
- Eukaryotic translation elongation factor, selenocysteine-specific
- Thioredoxin reductase 1, mitochondrial
- Inactive selenide, water dikinase-like protein
- Phosphoseryl tRNA kinase, isoform A
- GH01354p
- Glycine-rich selenoprotein
- serine--tRNA ligase
Sequence:
MFQPEKHGLEPDFQLTKFTTHTGUSCKIPQKVLEKYLRGTEIENKNNDGYLIGSGMDCAVIPLKRHKDYLLIQTVDFFYPMVNDPELLGRIALANVLSDVYAVGVTQFDTVEMIVSTSTSFSEKERDVVIGLVMKGFQNSLKANGYRNTPLIIRQLKINPWCIIGGIATSVCRSEEIILPSNAQPGDVLVLTKPLGGQMAMDAHLWQLNQTEKYKKLLSECSDADIKETFEIAVKSMTYLNKNAALLMHKYQAHCATDITGFGLLGHANNLAQFQKEKVLFQINKLPIIKNVLKFSTLVGQSTKFRSGRSVETSGGLLICLPADAADKFCRDFEEATNGEQKSFQIGHVTAANESDAVLCEDVEFIEVSL
Protein: RNA polymerase sigma factor FliA (RNA polymerase sigma factor for flagellar operon) (Sigma F) (Sigma-28) (A1JSP4)
Organism: Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00962}.
Interaction partners:
Sequence:
MSDLYTAEGVMDKNSLWQRYVPLVRHEALRLQVRLPASVELDDLLQAGGIGLLNAVERYDALQGTAFTTYAVQRIRGAMLDELRSRDWAPRSVRRNAREVASAMQKVEQRLGRPATEQEVAQNLDIDLTEYRQILLDTNNSQLFSYDEWREEHGESVEPMLEGHEDANPLQHLLEGNLRQRVIEAIEALPEREKMVLTLYYQEELNLKEIGAVLEVGESRVSQLHSQAIKRLRARLNNDS
Protein: G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) (Q8VEB1)
Organism: Mus musculus (Mouse)
Function: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane, targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion (By similarity). {ECO:0000250}.
Interaction partners:
- ARF GTPase-activating protein GIT1
- NADH-ubiquinone oxidoreductase chain 1
- Beta-arrestin-2
- Beta-arrestin-1
- Mu-type opioid receptor
- ARF GTPase-activating protein GIT2
- Beta-2 adrenergic receptor
- C-X-C chemokine receptor type 4
Sequence:
MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYYSLCDKQPIGRLLFRQFCETRPGLECYIQFLDLVAEYEITPDENLGAKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEKKLLQSPCKELFSACAQSVHDYLKGDPFHEYLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSSKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVPIPWQNEMIETECFKELNVFGPNGTLSPDLNRSQPPEPPKKGLFHRLFRRQHQSNSKSSPTPKTSCNHRINSNHINSNSTGSS