wanglab/gogpt-training-data huggingface dataset:
Protein: Protein STN1 (P38960)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.
Subcellular location: Chromosome, telomere {ECO:0000305}.
Interaction partners:
- Cell division control protein 13
- Telomere length regulation protein TEN1
- Telomere elongation protein EST1
- Cytochrome c1, heme protein, mitochondrial
- ATP-dependent DNA helicase II subunit 2
- Telomere length regulator protein RIF1
- Telomerase reverse transcriptase
- Telomere replication protein EST3
- ATP-dependent DNA helicase II subunit 1
- DNA polymerase alpha subunit B
Sequence:
MDKYGHIAHQEGDVCYYIPRLFKYNSYYSGTEDVRIFVGDLKYRMRVSLQICEKYYDRRLSMLFWKNHPLQQIHLIGCIIGLQFKWIGKQEYIFFQLDDCTSDSSLVGYTSDMRFLTCKVKKDSILSWGLNITDLIGLTLHVYGQASLNYQELQVEYLRLCYSLTEEIDHWKITMNMREQLDTPWSLSDFVIGELFTQEQEWTPETSQIEVVNPDFVGIGYKTPESKRNETTFIEQLQEERLKDELEIISPYNSTDTSNSVHSLSFRFVSSLKDFPETHFLNSGDQIDNGNDEQLKKLEYQSANLPVMIPNRTSAKSNLMLILLGLQMKEISNSDLYKLKEVRSVVTSLASFLFQQQNVGVMKSFDSLEKEAFRDLVNRLVSQGLIGLKDKTSETFDLLPLKNLFEYAEKRISVLMKLQCYTGTVQLSHVQEKLHLPYITTNGIVDVFKECLKRTKKQYPEVLKNWWIDLDPKNGMEDQNSGILLHLEYAAAYS
Protein: Protein EARLY FLOWERING 5 (AtELF5) (Q9LV14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the regulation of flowering time in both long and short days.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:15125772}.
Interaction partners:
- Cell division cycle 5-like protein
- Cwf15 / Cwc15 cell cycle control family protein
- At2g29210/F16P2.41
- Pre-mRNA-splicing factor 38
- ARM repeat superfamily protein
- Pre-mRNA-processing protein 40C
- Pre-mRNA-splicing factor SPF27 homolog
- Ubiquitin-like superfamily protein
- Ubiquitin-like protein 5
- At2g32600/T26B15.16
Sequence:
MKTTKGGKVMNPTDAYRKQIRKREIKRNKKERQKVREVGILKKDPEQIKDQIRKLDMSKAEGALDKARKHKKRQLEDTLKMVVKKRKEYDEKKKEQGEATTSVMFSHLPPQRRLTGEEDLKPEDSVYYHPTLNPTGAPPPGKPPMYNSSIGLAISSDGASSSSAALSSITESEDSVLVNPPPLPPLPDGDNALSASLPLPPLPPLPPTTGLTLPHSPFPPPPPGPPPKEQDFVRPPLPPPPQLPQSSQPPPPGLSGSQGDGRFPESSDFTFDNRMNANITSVPLLPPPGIPSNESESRPAESNASSFQNANLSKMVAPPPPAPLHQQHQSTFAGAAASLTNFQPDVHPPPGMLRFPPPPPPLDMHPPHPGMFVGHLIPRPPYGPPPGPPPMMRPPLPPGPPPSSFQDGQAMIRPYVPNKPSFVKSAAPTVVRRPLAQHTPELTSMVPASVRVRRESATVTKPKPKTSIASSLSFTPRAMASAATVKVEPAKTSAASKPQSIDDSYTAFLEDMKALGALDG
Protein: Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) (H7C579)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XPRAAARVRAAGEALERRRRWLGRLSPSAPRPRRARPSLRRASAWVRDRVAGRPGALPGFQASGVAGEAQKAPGHPAAPAPAASCLTEADGRVFLHAFRLALIQLQISSIKSDNVTRACSFIREAATQGAKIVSLPECFNSPYGAKYFPEYAEKIPGESTQKLSEVAKECSIYLIGGSIPEEDAGKLYNTCAVFGPDGTLLAKYRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCRVGLGICYDMRFAELAQIYAQRGEA
Protein: VipD (Q5ZRP9)
Organism: Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Interaction partners:
Sequence:
MKLAEIMTKSRKLKRNLLEISKTEAGQYSVSAPEHKGLVLSGGGAKGISYLGMIQALQERGKIKNLTHVSGASAGAMTASILAVGMDIKDIKKLIEGLDITKLLDNSGVGFRARGDRFRNILDVIYMMQMKKHLESVQQPIPPEQQMNYGILKQKIALYEDKLSRAGIVINNVDDIINLTKSVKDLEKLDKALNSIPTELKGAKGEQLENPRLTLGDLGRLRELLPEENKHLIKNLSVVVTNQTKHELERYSEDTTPQQSIAQVVQWSGAHPVLFVPGRNAKGEYIADGGILDNMPEIEGLDREEVLCVKAEAGTAFEDRVNKAKQSAMEAISWFKARMDSLVEATIGGKWLHATSSVLNREKVYYNIDNMIYINTGEVTTTNTSPTPEQRARAVKNGYDQTMQLLDSHKQTFDHPLMAILYIGHDKLKDALIDEKSEKEIFEASAHAQAILHLQEQIVKEMNDGDYSSVQNYLDQIEDILTVDAKMDDIQKEKAFALCIKQVNFLSEGKLETYLNKVEAEAKAAAEPSWATKILNLLWAPIEWVVSLFKGPAQDFKVEVQPEPVKVSTSENQETVSNQKDINPAVEYRKIIAEVRREHTDPSPSLQEKERVGLSTTFGGH
Protein: Trans-2'-carboxybenzalpyruvate hydratase-aldolase (EC 4.1.2.34) (Q79EM8)
Organism: Nocardioides sp. (strain KP7)
Function: Plays a role in phenanthrene catabolism. Catalyzes the transformation of trans-2'-carboxbenzalpyruvate to 2-formylbenzoate and pyruvate.
Interaction partners:
Sequence:
MTSPAVTSADITGLVGIVPTPSKPGSEAPDAVDTVDLDETARMVELIVASGVDVLLTNGTFGEVATLTYEELLAFNDTVIRTVANRIPVFCGASTLNTRDTIARSLALMGLGANGLFVGRPMWLPLDDEQLVSYYAAVCDAVPAAAVVVYDNTGVFKGKISSAAYAALAEIPQIVASKHLGVLSGSDAYASDLAAVKGRFPLLPTADNWLPSLEAFPGEVPAAWSGDVACGPEPVMALRRAIAEGLWDDARAVHEDIAWATEPLFPGGDISKFMPYSIQIDRAEFEAAGYIVPGPSRHPYGTAPAAYLEGGAEVGRRWAGIRQKYVATLAEP
Protein: SCF ubiquitin ligase complex protein SKP1b (Glycoprotein FP21 isoform B) [Cleaved into: SCF ubiquitin ligase complex protein SKP1b(4-162); SCF ubiquitin ligase complex protein SKP1b(6-162)] (Q557E4)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- VWFA domain-containing protein
- Protein SGT1 homolog
- SCF ubiquitin ligase complex protein SKP1a
- Cullin-5
- UDP-galactose:fucoside alpha-3-galactosyltransferase
- UBR-type domain-containing protein
- RING-box protein 1
- Uncharacterized protein
- Cullin-1
- Uncharacterized protein
Sequence:
MSLVKLESSDEKVFEIEKEIACMSVTIKNMIEDIGESDAPIPLPNVTSTILEKVLDYCRHHHQHPSPQGDDKKDEKRLDDIPPYDRDFCKVDQPTLFELILAANYLDIKPLLDVTCKTVANMIRGKTPEEIRKIFNIKNDFTPEEEEQIRKENEWCEDKGGN
Protein: Complement C8 alpha chain (D3ZWD6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Complement component C8 gamma chain
- Complement component C8 beta chain
- Complement component C9
- Complement C5
- Complement component C6
- Complement C7.
- ADP/ATP translocase 2
- ADP/ATP translocase
- ADP/ATP translocase 1
- CD34 molecule
Sequence:
MFTVAFFGLSLMAWHSGVTAQEKVNQRVTRAVTPGAVACQLSDWSEWTDCFPCQNEKYRYRSLLQPSKFGGTICSGDIWDKANCDSPTPCLRQAQCGQDFQCRETALYHAGRCLKRHLVCNGDQDCLDGSDEDNCDDARVIEDDCRQYEPIPGSERAALGYNILTQEEGQSVYDAKYYGGQCETVYNGDWRRLQYDPTCERLYYGEDEKYFRKPYNFLKYHFEALADTLISSEFYDDANDLFSKIQRDKSQSNSVTFGISPAKSPITLDASVSWSDESSFMKELSKYNEKKYSFMRVSTKVQTAHFKMRRHNIVLDEGMMESLMELPEQFNYGMYSKFINDYGTHYITSGTMGGIYEYVLVLDKEKMRIHGITVEDVKKCIGGGVGLQFGEKIIGEGDLSGESCVMTGDGNQDKRKKDLAVEDIISRVQGGSSRWSTGLAHNSSAITYRSWGRSLKYNPVVIDFEMQPIYQLLQHTNLGPLETKRRNLRRALDQYLMEFNACRCGPCFNNGVPILEGTSCSCQCSMGRQGPACESMVLEAMEGAKADGRWSCWSSWSECRGGSRERRRQCNNPAPQNGGAPCLGKSLQTQAC
Protein: Slimb (O44382)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMKMETDKIMDETNSNAQAFTTTMLYDPVRKKDSSPTYQTERELCFQYFTQWSESGQVDFVEHLLSRMCHYQHGQINAYLKPMLQRDFITLLPIKGLDHIGENILSYLDAESLKSSELVCKEWLRVISEGMLWKKLIERKVRTDSLWRGLAERRNWMQYLFKPRPGQTQRPHSFHRELFPKIMNDIDSIENNWRTGRHMLRRINCRSENSKGVYCLQYDDGKIVSGLRDNTIKIWDRTDLQCVKTLMGHTGSVLCLQYDDKVIISGSSDSTVRVWDVNTGEMVNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMTSPSEITLRRVLVGHRAAVNVVDFDEKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNSIRLWDIECGACLRVLEGHEELVRCIRFDTKRIVSGAYDGKIKVWDLVAALDPRAASNTLCLNTLVEHTGRVFRLQFDEFQIVSSSHDDTILIWDFLNFTPNENKTGRTPSPALMEH
Protein: Cell division related protein-like (DnaJ and myb-like DNA-binding domain-containing protein) (Q9LHS5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- ARM REPEAT PROTEIN INTERACTING WITH ABF2
- Signal peptide peptidase-like 2
Sequence:
MQSWGINSAIKLLTYSSELKDGQALYASSNCHPVKALNREPAGHAFHSAALKLRGCAKEATSKNEDTDKKVPKEKDGEYIPSYDSHNIKGKKKSGKLQHDHYALLGLGNLRYLATDDQIRKSYRDAALKHHPDKLATLLLLEETEEAKQAKKDEIESHFKLIQEAYEVLMDSTKRRIFDSTDEFDDKVPTDCAPQDFFKVFGPAFKRNARWSNSPLPDLGDENTPLKEVDRFYSTWYTFKSWREFPEEEEHDIEQAESREEKRWMERENARKTQKARKEEYARIRTLVDNAYKKDIRIQKRKDDEKAKKLQKKEAKVMAKRQQEEAAAAAIEEEKRRKEEEAKRAAEAAQLHKRAKEREKKLLRKERSRLRVLSAPVLSQRLLGISDEHVEDLCMSLNTEQLRKLCDKMENKEGMALAKVIKNGSNIDDDKIEIEEEEVQVAVKQNGHIEANGHVEANGHVEAKVDTATHEKKEKPWSKEEIDMLRKGTTKFPKGTSQRWEVISEYIGTGRSVEEILKATKTVLLQKPDSAKAFDSFLENRKPAASINSPLSTREELGEPIIPTKAHEDNNSTKTETAEQNGKTKENNNSNGNSEPAAASGSDPDGWSAVQERALVQALKTFPKETNQRWERVATAVPGKTMNQCKKKFADLKDVIRTKKPTA
Protein: Superoxide dismutase (EC 1.15.1.1) (Q381J5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- I/6 autoantigen
- Large ribosomal subunit protein uL15/eL18 domain-containing protein
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL29m
Sequence:
MTFSIPPLPWGYDGLAAKGISKEQVTFHYDKHHMGYVTKLNAVAACNAAVAAKSVEEIIRTEKGPIFNLAAQIFNHDFYWESISPNGGGEPSGKLADAIADSFGSFARFKEEFTNAAVGHFGSGWAWLVQDTTTKKLKVFQTHDAGCPLTEADLKPILACDVWEHAYYIDYKNDRPAYVQTFWNVVNWAHAEEQLLKS
Protein: Symplectin (EC 3.5.-.-) (C6KYS2)
Organism: Sthenoteuthis oualaniensis (Purpleback flying squid) (Symplectoteuthis oualaniensis)
Function: Monovalent ion-dependent bioluminescence photoprotein. Displays an emission peak at 470 nm (blue light). Trace amounts of monovalent ion trigger the intramolecular oxidation of the chromophore, didehydrocoelenterazine, with the emission of light.
Interaction partners:
Sequence:
YVRPVSSWKVAVFEHQVIPPKTDMETREEALDALKLNSDVYHEAVLESRSKGVKMIVFPEYGLYDINTLTRTRMDLMAEKVPHPKHGHRNPCDEPEYQTQSSEMLRTFSCMAKENDMYMVVNMAGREPCRRATEPECPGDKQLLYNTNVAFNNEGDVVARYYKTHLFWEEGWFNSSKNYEMALWDTPIGKFGTFMCFDFQAVQLIEQYNVRHIAYPASWVNLPPIYQSIQSHSAFARFAKINLLAASVHRLETSTYGSGIYSPNGAEIFYFRPDIPKSKLLVAEILPIHVKKPEQTVVNFDNPVFPSEDDDVQDLFDRGDFAFLKYKRMTTRAGTVEVCQKSFCCKARYAVKDRFKEVYAVGVYDGLLSAGANNLYFQICTVIQCPHKKCGLKISKVRTHFKYLNLRADGWLDRYVFPSYTVMYNNYIALDPFVWNYTEAGGIETKPGTSTPLHSANLVARIYAKDSSKHVHQSHPIDEGVIKMAVKYMLYVMAAYVYAAS
Protein: Late cornified envelope protein 2B (Late envelope protein 10) (Skin-specific protein Xp5) (Small proline-rich-like epidermal differentiation complex protein 1B) (O14633)
Organism: Homo sapiens (Human)
Function: Precursors of the cornified envelope of the stratum corneum.
Interaction partners:
- Late cornified envelope protein 2D
- Late cornified envelope protein 6A
- Late cornified envelope protein 1A
- Late cornified envelope protein 2C
- Late cornified envelope protein 1B
- Late cornified envelope protein 1F
- Late cornified envelope protein 4A
- Late cornified envelope protein 1D
- Late cornified envelope protein 2A
- Late cornified envelope protein 3D
Sequence:
MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC
Protein: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) (A0A0B4JCW4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03220}.
Interaction partners:
Sequence:
MASFLARTGGPLIETVRPAAIKKILGLAPIAVQQLRNLNVQEHVSYSLLNEAKIPTPRFAVAKNGKEANDIATKLKTDNLVLKAQVLAGGRGKGTFKNGLKGGVRVVYDPQTAEELSSKMIDQLLVTKQTGAAGRICKKVMVAERKFPRREFYFAVMMERAFNGPVLIASKEGGVDIEEVAASSPDAILYEPIDIGTGLTSEQAEKIVKKVGLGGDGEDTHVQMLLNLYDLFVKKDALLVEINPYAEDAMSGFFALDAKLRFDDNAEFRQKELFALRDWTQEDPKEVEAAKYNLNYIALDGTIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGATAEAVKAAFKIITSDPKVLCILVNIFGGIMRCDVIAEGIISATKDLNLNMPVVVRLQGTKVKEARELIRTSGLKILARDDLDKAADLAVHLAQIVKLAREMKMDVNFEIPDAQK
Protein: 3-ketodihydrosphingosine reductase (3-KDSR) (EC 1.1.1.102) (KDS reductase) (Q8A945)
Organism: Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
Function: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
Interaction partners:
Sequence:
MQPQIILITGASSGFGKITAQMLSEQGHIVYGTSRKPSENIGKVRMLVVDVTNSISVRQAVEQIISEQGRMDVLINNAGMGIGGALELATEEEVSMQMNTNFFGVVNMCKAVLPYMRKARRGKIINISSIGGVMGIPYQGFYSASKFAVEGYSEALALEVHPFHIKVCLVQPGDFNTGFTDNRNISELTGQNEDYADSFLRSLKIIEKEERNGCHPRKLGAAICKIVARKNPPFRTKVGPLVQVLFAKSKSWLPDNMMQYALRIFYAIR
Protein: Noelin (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) (Q99784)
Organism: Homo sapiens (Human)
Function: Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:O88998}. Synapse {ECO:0000250|UniProtKB:O88998}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O88998}. Cell projection, axon {ECO:0000250|UniProtKB:O88998}. Perikaryon {ECO:0000250|UniProtKB:O88998}.
Interaction partners:
- Teneurin-4
- Histone-lysine N-methyltransferase EHMT1
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Reticulon-4 receptor
- Actin-binding protein WASF1
Sequence:
MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLSAAGGGTLDRSTGVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMKGLESKFKQVEESHKQHLARQFKAIKAKMDELRPLIPVLEEYKADAKLVLQFKEEVQNLTSVLNELQEEIGAYDYDELQSRVSNLEERLRACMQKLACGKLTGISDPVTVKTSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVREYKSMVDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKTETILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDESGLWAVYATNQNAGNIVVSRLDPVSLQTLQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQILYNVTLFHVIRSDEL
Protein: Large ribosomal subunit protein uL24z (60S ribosomal protein L26-1) (P51414)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL10x
- Large ribosomal subunit protein uL4z
- Large ribosomal subunit protein uL10y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL27x
- Large ribosomal subunit protein eL27y
- Large ribosomal subunit protein eL8y
- Small ribosomal subunit protein eS24y
Sequence:
MKYNPRVTSSRRKNRKAHFTASSSERRVIMSSPLSTDLRQKYNVRSMPIRKDDEVQIVRGTYKGREGKVVQVYRRKWVIHIERITREKVNGTTVNVGIQPSKVVITKLRLDKDRKSLLERKAKGRAAADKEKGTKFTSEDVMQNVD
Protein: G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 (EC 2.7.12.1) (Protein LIPOOLIGOSACCHARIDE-SPECIFIC REDUCED ELICITATION) (S-domain-1 (SD1) receptor kinase 29) (SD1-29) (O64782)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: S-domain receptor protein kinase involved in lipopolysaccharide (LPS) sensing. Specifically detects LPS of Pseudomonas and Xanthomonas species. LPS are major components of the outer membrane of Gram-negative bacteria and are important microbe-associated molecular patterns (MAMPs) that trigger biphasic production of reactive oxygen species (ROS) and immune responses in plants. Seems to be only partially associated with the second LPS-triggered ROS burst. Mediates defense signaling in response to the medium-chain 3-hydroxy fatty acid 3-OH-C10:0, a pathogen-associated molecular pattern (PAMP) which induces autophosphorylation at Tyr-600. Autophosphorylation at Tyr-600 is required for downstream phosphorylation of the receptor-like cytoplasmic kinase PBL34, PBL35 and PBL36, and activation of plant immunity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25729922, ECO:0000269|PubMed:31922267}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Metacaspase-3
- WRKY family transcription factor
Sequence:
MGMVLFACLLLLIIFPTCGYAAINTSSPLSIRQTLSSPGGFYELGFFSPNNTQNQYVGIWFKKIVPRVVVWVANRDTPVTSSAANLTISSNGSLILLDGKQDVIWSTGKAFTSNKCHAELLDTGNFVVIDDVSGNKLWQSFEHLGNTMLPQSSLMYDTSNGKKRVLTTWKSNSDPSPGEFSLEITPQIPTQGLIRRGSVPYWRCGPWAKTRFSGISGIDASYVSPFSVVQDTAAGTGSFSYSTLRNYNLSYVTLTPEGKMKILWDDGNNWKLHLSLPENPCDLYGRCGPYGLCVRSDPPKCECLKGFVPKSDEEWGKGNWTSGCVRRTKLSCQAKSSMKTQGKDTDIFYRMTDVKTPDLHQFASFLNAEQCYQGCLGNCSCTAFAYISGIGCLVWNGELADTVQFLSSGEFLFIRLASSELAGSSRRKIIVGTTVSLSIFLILVFAAIMLWRYRAKQNDAWKNGFERQDVSGVNFFEMHTIRTATNNFSPSNKLGQGGFGPVYKGKLVDGKEIGVKRLASSSGQGTEEFMNEITLISKLQHRNLVRLLGYCIDGEEKLLIYEFMVNKSLDIFIFDPCLKFELDWPKRFNIIQGIARGLLYLHRDSRLRVIHRDLKVSNILLDDRMNPKISDFGLARMFQGTQYQDNTRRVVGTLGYMSPEYAWAGLFSEKSDIYSFGVLMLEIISGKRISRFIYGDESKGLLAYTWDSWCETGGSNLLDRDLTDTCQAFEVARCVQIGLLCVQHEAVDRPNTLQVLSMLTSATDLPVPKQPIFAVHTLNDMPMLQANSQDFLSVNEMTESMIQGR
Protein: Taiman, isoform E (M9MRJ8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSIAAAENAGLSPSDLPDHWASGTSNPSTSTSSSSSSSISASGSNNNKYNSGNISVCNLPRSSPAAATAAVTLSSAAGGIGSNLLSGLHHGLAPGTHPLQRATAASGGGAGAGGVAGASTAAALTLQQHQHQQQQQQQQQQAQHQHQHQHQQQTQQQQLAYQHQQLQQQIISHRSIQNKAAATAAAQTANLAAALQRSAAIMNAVASPISANSANSATSGRKIRRKTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKRGDMTSTKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQTSSNCEEKPLRQSGHQDKYEEVVLIAAPVKDDADASSSVLCLITRPEDESPLEINIQQHVQQQPIEQMTFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQDLCHPHDLSTLKSHLRDIQDSASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAASGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASPAPAEHSFYGSDTFEFDIAAHSSSFELDPSGGVGAWTDSRPNSRASVATPVSTPRPPSGHGFSPAVCASPATPYQLSSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDVKPEKDVQQQQNQQQSNNNSSSSNPLLGGGLPNGVGGMLLSQQQQQQQTPPQQQQQQQQQESSERLRHLLTKSQSMAGGLGGLGDDEKYFKPEGSEEEKHASGGFKMGGQPGGMGMFGPMGSMGRGVGNSSMLHKAGNSQNPMLLKLLNEKSEDDDGNGSGGGPGSMNNSRQSELMRQLKNPDGGSHGMHRNSASGNMSTEDLKAMLKIQSDPSLNRKRSLNEPDDDPSAKRSEDKPSKLCTQNKMLAKLLQNPPKIPKAPNPEQPLQVKTLPDITSSTVSSTLAAPGNLISAGSTGPKAAANRNRKQQQQQQQQQQQQQQQQVAGIPSQQQQQQPNDVYLSQQQQQQLQSPQLAFQHQQLATTATTSITTAASTSAAAAAAAAILGEGDSELSKLLDSVMEYYPDDTPIVTNAPSEASAINDIQKSLMLDVESAAFGNDLNQQLMMTQQQQHQQQQQQQQLLALQLAQQQQQQRQQHLQQPPAYPGMLNMQQQQHQQQQQQNQQHIMQRLEAMRNQGNQGFQRPPPMYPARGRGPMNAVATPGGVVLPAQQQLRNIRQQQQLAAAQQKERLLQQQQKQQLLVPENATGMNAGLNNIGSLLNTTGAPNVSLSRTNLPSDAQLSPNFAQTLMQQQLSPGRSAPYSPQPNQGYAPQFPQPGQRLSPQQQQQLSQQQQNNVQQQQLAYQQQQVGDGGRSNTPFGSNSGMQSPGMQNSPQQWGSGGGGGGGPGGPLPSGNAGRTLQQHNPMLIAQLQNQRRGLNSPGAVGPGGNPAAQAALQRQNSFQGQGGGGATTPDGSGVGFGGPQSPYGTNVNVFQQQQLQRLQRQGSVPQATQHLPGSPRFGSSPGSSNNTDSSAAAGNQQQQQQQQQQQQQQHQQQQHQQLMNGLSMSPHPHPHPAMMGVGGMGSGGGNGIIGLGGGGGNYGATLGGYGQSQQANDFYGRAQTAGGGGSVAGGNANSEFVKQELRAVVSVRAQQAAAAATGGAGVGGGVAQRGQTPQSPLQQGSVIGGGGGIVGGVNSTNTMGNVTPTGSGNVSNSMLNTPPDPTLSFSFETPDFFTSSATR
Protein: (3R)-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (Estradiol 17-beta-dehydrogenase 8) (EC 1.1.1.62) (Protein Ke6) (Ke-6) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239) (P50171)
Organism: Mus musculus (Mouse)
Function: Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex, acts as scaffold protein, required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference, this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+)(H). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (By similarity). NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. It efficiently catalyzes the oxidation of estradiol (E2), testosterone, and dihydrotestosterone. Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active estradiol (E2).
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q92506}.
Interaction partners:
- 3-oxoacyl-[acyl-carrier-protein] reductase
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- Very-long-chain 3-oxoacyl-CoA reductase
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- 17-beta-hydroxysteroid dehydrogenase type 1
- 17-beta-hydroxysteroid dehydrogenase type 6
- Estradiol 17-beta-dehydrogenase 2
- Polycomb complex protein BMI-1
- Polyprenal reductase
- Dehydrogenase/reductase SDR family member 11
Sequence:
MASQLRLRSALALVTGAGSGIGRAISVRLAAEGAAVAACDLDGAAAQDTVRLLGSPGSEDGAPRGKHAAFQADVSQGPAARRLLEEVQACFSRPPSVVVSCAGITRDEFLLHMSEEDWDRVIAVNLKGTFLVTQAAAQALVSSGGRGSIINISSIIGKVGNIGQTNYASSKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKMPEKVKDKVTAMIPLGHMGDPEDVADVVAFLASEDSGYITGASVEVSGGLFM
Protein: Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) (P17785)
Organism: Gallus gallus (Chicken)
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=In the lamina beneath the plasma membrane.
Interaction partners:
- Protein S100-A10
- PDZ domain-containing protein.
- Plasminogen
- Plasminogen activator
- Plasminogen
- Annexin A1
- EF-hand domain-containing protein.
- EF-hand domain-containing protein.
- Cathepsin B
- Protein S100-A6
Sequence:
MSTVHEILSKLSLEGDHSLPPSAYATVKAYSNFDADRDAAALEAAIKTKGVDEVTIINILTNRSNEQRQDIAFAYQRRTKKELSAALKSALSGHLEAVILGLLKTPSQYDASELKAAMKGLGTDEDTLIEIICSRTNQELNEINRVYREMYKTELEKDIISDTSGDFRKLMVALAKGKRCEDTSVIDYELIDQDARELYDAGVKRKGTDVPKWINIMTERSVPHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKQLYFADRLYDSMKGKGTRDKVLIRIMVSRCEVDMLKIKSEFKRKYGKSLYYFIQQDTKGDYQRALLNLCGGED
Protein: Paired box 5 (E7ES87)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSPYYYSAAARGAAPPAAATAYDRH
Protein: Peroxidase (EC 1.11.1.7) (A8W7V9)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU362060}.
Interaction partners:
Sequence:
MAKCSVLLFLCLVMVSINVANTMNETCVDDISIVLQIDLYKNSCPEAESIIYSWVENAVSQDSRMAASLLRLHFHDCFVNGCDGSVLLDDTEDFTGEKTALPNLNSLRGFEVIDAIKSELESVCPQTVSCADILATAARDSVVISGGPSWEVEMGRKDSLGASKEAATNNIPGPNSTVPMLVAKFQNVGLSFNDMIALSGAHTLGMARCSTFSSRLQGSNGPDINLDFLQNLQQLCSQTDGNSRLARLDLVSPATFDNQYYINLLSGEGLLPSDQALVTDDYQTRQLVLSYAEDPLAFFEDFKNSMLKMGSLGVLTGTDGQIRGNCRVVN
Protein: Ferric enterobactin receptor (Q05098)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Specific receptor for the siderophore ferric enterobactin.
Subcellular location: Cell outer membrane {ECO:0000255|PROSITE-ProRule:PRU01360}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU01360}.
Interaction partners:
- Iron
- Second ferric pyoverdine receptor FpvB
- Metal-pseudopaline receptor CntO
- Sensor protein PfeS
- Ferric-mycobactin receptor, FemA
- Ferric enterobactin receptor PirA
- Transcriptional activator protein PfeR
- Metal-pseudopaline receptor CntO
- Ferripyoverdine receptor
- Fe
Sequence:
MSSRALPAVPFLLLSSCLLANAVHAAGQGDGSVIELGEQTVVATAQEETKQAPGVSIITAEDIAKRPPSNDLSQIIRTMPGVNLTGNSSSGQRGNNRQIDIRGMGPENTLILVDGKPVSSRNSVRYGWRGERDSRGDTNWVPADQVERIEVIRGPAAARYGNGAAGGVVNIITKQAGAETHGNLSVYSNFPQHKAEGASERMSFGLNGPLTENLSYRVYGNIAKTDSDDWDINAGHESNRTGKQAGTLPAGREGVRNKDIDGLLSWRLTPEQTLEFEAGFSRQGNIYTGDTQNTNSNNYVKQMLGHETNRMYRETYSVTHRGEWDFGSSLAYLQYEKTRNSRINEGLAGGTEGIFDPNNAGFYTATLRDLTAHGEVNLPLHLGYEQTLTLGSEWTEQKLDDPSSNTQNTEEGGSIPGLAGKNRSSSSSARIFSLFAEDNIELMPGTMLTPGLRWDHHDIVGDNWSPSLNLSHALTERVTLKAGIARAYKAPNLYQLNPDYLLYSRGQGCYGQSTSCYLRGNDGLKAETSVNKELGIEYSHDGLVAGLTYFRNDYKNKIESGLSPVDHASGGKGDYANAAIYQWENVPKAVVEGLEGTLTLPLADGLKWSNNLTYMLQSKNKETGDVLSVTPRYTLNSMLDWQATDDLSLQATVTWYGKQKPKKYDYHGDRVTGSANDQLSPYAIAGLGGTYRLSKNLSLGAGVDNLFDKRLFRAGNAQGVVGIDGAGAATYNEPGRTFYTSLTASF
Protein: Transmembrane protein 256 (Q5F285)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MAGVGAAFRRLGALSGAGALGLASYGAHGAQFPDAYGKELFDKANKHHFLHSLALLGVPSCRKPVWAGLLLASGTTLFCTSFYYQALSGDTSIQTLGPVGGSLLILGWLALAF