wanglab/gogpt-training-data huggingface dataset:
Protein: COP9 signalosome complex subunit 8 (Signalosome subunit 8) (Q75K24)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 1
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 7
- Cullin-4
- Ubiquitin-like protein NEDD8
- DNA damage-binding protein 1
Sequence:
MAFTEIANLISSKNFKAILDYCQRQEIESKNIDLIKSYYGVYLLSYLINNDLINAKHLWKRIPNDFKQSNQQLKNIYTIIKSISQTNPTITYTSLSINIGDDYTPFITTLKENFQQRTFELISNAYSSITVNDCSSYLGISPEDTIKFTTSKCWEHDKASNTLKPVPIQKQSSELPTGNQQIRSLTSYVLFLEKST
Protein: Histocompatibility 2, class II, locus Mb2 (F7AD18)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH
Protein: ribonucleoside-diphosphate reductase (EC 1.17.4.1) (P88951)
Organism: Human herpesvirus 8 type M
Interaction partners:
Sequence:
MDSVDRFLYTSDHDGFLALTRETWQNRWFPSQIPLHLDVSHVHQLSDADKDFYRFLFTFLGMAERLVNFNIEDLVTNFNSHDVAHYYAEQVAMENIHGVVYANILKIFFNNSRGELLAYAAKIILDPALCEKLEWLHSRVRKATTKAQKILMFLIVEGIYFISSFYSISLCRVRGIMPGVCLANDYISRDELLHTKAASMLYNTMVEIQEKPSHAEVQALFREAVNIEIRFIQAKAAGVTLVNVVDIRRFLEATADRILRDIFVPPIFGTPPPEACPLSYTGSFKAVNFFERDNSDYTTCVTDDL
Protein: Forkhead box N2 (D3Z6Z3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGPVIGMTPDKRAETPGAEKVAGLSQIYKMGSLPEAGDAARPKATLVGSESADDELTNLNWLHESSNLLTNLRLGSEGLPMVSPLYDIEGDEMPSFGPSCYQN
Protein: Chlorophyll a-b binding protein (LHCII type I CAB) (LHCP) (Q9T2L1)
Organism: Spinacia oleracea (Spinach)
Function: The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:1894641}; Multi-pass membrane protein {ECO:0000269|PubMed:1894641}.
Interaction partners:
Sequence:
RKSAGKPKN
Protein: Phosphatidylinositol 4-kinase gamma 4 (AtPI4Kgamma4) (PI-4Kgamma4) (PI4K gamma 4) (EC 2.7.1.67) (Ubiquitin-like domain kinase gamma 4) (UbDK gamma 4) (Q9ZPY9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). Undergoes autophosphorylation and phosphorylates serine/threonine residues of protein substrates. Phosphorylates RPN10 and UFD1 in vitro.
Subcellular location: Membrane {ECO:0000269|PubMed:23323832}; Peripheral membrane protein {ECO:0000269|PubMed:23323832}; Cytoplasmic side {ECO:0000269|PubMed:23323832}.
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- AT2G21270 protein
- E3 ubiquitin-protein ligase UPL4
- Protein NBR1 homolog
- E3 ubiquitin-protein ligase PRT1
- E3 ubiquitin-protein ligase UPL3
- Oxysterol-binding protein-related protein 1C
- Phosphatidylinositol 4-kinase beta 1
- U-box domain-containing protein 2
- E3 ubiquitin-protein ligase UPL5
Sequence:
MSSAGVALSPVRSEPLIMPLVRANSCLDSYPDDTIMIYLTLPGSVIPMRVLESDSIESVKLRIQSYRGFVVRNQKLVFGGRELARSNSNMRDYGVSEGNILHLVLKLSDLQVLDVKTTCGKHCRFHVERGRNIGYVKKQISKKRGDFVDPDEQEILYEGEKLEDQSLINDICRNDDSVLHLLVRRSAKVRVKPVEKNFELSIVAPQAKDKKGREAKSIVPPKKLSLEPVVVNSKAKVPLVVKDMIQSASDGLKSGNSPVRSSEGTGGAYFMQGPSGNKFVGVFKPIDEEPMAENNPQGLPLSPNGEGLKKGTKVGEGALREVAAYILDHPKSGNKSMFGEEIGFAGVPPTAMIECLHPGFNHPKGIKTKIGSLQMFTENDGSCEDMGPLSFPVEEVHKISVLDIRLANADRHGGNILMTKDESGKLVLVPIDHGYCLPESFEDCTFEWLYWPQARKPYSAETQEYIRSLDAEEDIDLLKFHGWKMPAETAQTLRISTMLLKKGVERGLTAFEIGTIMCRETLSKKSLVEEMVEEAQEAVLPGTSEAAFLEALSDVMDYHLDHSQEH
Protein: Cytosolic 5'-nucleotidase 1B (cN1B) (EC 3.1.3.5) (Autoimmune infertility-related protein) (Cytosolic 5'-nucleotidase IB) (cN-IB) (Q91YE9)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, AMP is the major substrate.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BXI3}.
Interaction partners:
- 7-methylguanosine phosphate-specific 5'-nucleotidase
- 5'
- Cytosolic 5'-nucleotidase 3A
- 5'
- Cytosolic purine 5'-nucleotidase
- Adenylosuccinate synthetase isozyme 1
- Inosine triphosphate pyrophosphatase
- Deoxycytidine kinase
- Adenylosuccinate lyase
- UMP-CMP kinase 2, mitochondrial
Sequence:
MSQTSLKHKKKNEPGMRYSKESLDAEKRKDSDKTGARLSTQGSQELPLHNTDSRGYVVRNQWSRTSRSPSTGAPSVDEPRSRNTAIKVEAPNSSTTSRTSSASPSQHETSPPPQTSEKSSIQQTPQNRPITQLESQPPTPPETEPNSRRTSAKMYTGSDPWAHRENREPRDLQLRDYAYSCDSREGMPKTREYPRTPPTEWKPYAQRRLQYGTSVDMEPEYISDGPQQRQRQQTEEDEVDEAYWTSVSMLYEKIPSCARPRPPKPKHAITIAVSSRALFNMVDDRKIYEEEGLEKYMEYQLTNENVILTPGPAFRFVKALQHVNSRLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKSPIGYLKAYLTNLYLSADSEKVQEAIKEGIASATMYAGAKDMAYCDTQLRVAFDGDAVLFSDESEHIAKDHGLDKFFQHETLFENKPLAQGPLKSFLEDLGKLQKKFYAKDERLLCPIRTYLVTARSAASSGARVLKTLRRWGLEIDEALFLAGAPKGPILVKIRPHIFFDDQMFHIESAQKFGTITAHVPYGIAQKRN
Protein: FAM20C, golgi associated secretory pathway kinase (A0A8I5ZV45)
Organism: Rattus norvegicus (Rat)
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MSVVAVPETLVRLCFLCHHCHPLHRRVSLADPRDGLESRCFGGGRCRLGAKLRGTGGARVRNPPSPLACAVMKMILVRRFRVLILVVFLLACALHIAVDLLPKLDRRATRSPGEPGCSCAQPAAEAAGPGWAQARSRPGESAGGDAGWPNKHTLRILQDFSSDPASNLTSHSLEKLPPAAEPVDHAPRGQELGSPPPRDSAHRPLLRDPGPGPRVPPHGPRGDGSLLAKLFEHPLYQGAVPPLTEGDVLFNVNSDIRFNPRAAENPDWPLEGAEGAEFLPTGEAAVDLYPNWLKFHIGINRYELYSRHNPAIDALLHDLGSQKITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMINMTKEIRDVTRDKKLWRTFFVSPANNICFYGECSYYCSTEHALCGKPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSGHRILDIMDMTVFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILAPLHQCCRIRRSTYLRLQLLAKEEYKLSLLMAESLQHDKVAPVLYQLHLEALDRRLRIVLQAVRDCVEKDGVSSVVEDDLATEHRASTER
Protein: Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31) (Q9SUC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000250}.
Interaction partners:
- 3-hydroxyisobutyryl-CoA hydrolase-like protein 3, mitochondrial
- Probable 3-hydroxyisobutyryl-CoA hydrolase 3
- 3-hydroxyisobutyryl-CoA hydrolase-like protein 4, mitochondrial
- 3-hydroxyisobutyryl-CoA hydrolase 1
- Probable 3-hydroxyisobutyryl-CoA hydrolase 2
- 3-hydroxyisobutyryl-CoA hydrolase-like protein 1, mitochondrial
- 3-hydroxyisobutyryl-CoA hydrolase-like protein 5
- Small ribosomal subunit protein mS47
- Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
- Alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial
Sequence:
MAIRRAQTLLCLSKFKTNFVSGSLHRFSSSSQNSNQFQNVGFIGLGNMGFRMVNNLIRAGYKVTVHDINRDVMKMFTEMGVSSRETPYEVAQDSEVVITMLPSSSHVMDVYTGTNGLLLGENDIRPALFIDSSTIDPQTTRKISLAVSNCNLKEKRDNWEKPVMLDAPVSGGVLAAEAGTLTFMVGGPEDAYLAARPILQSMGRTSIYCGGSGNGSAAKICNNLAMAVSMLGTSEALALGQSLGISASTLTEVLNTSSGRCWSSDAYNPVPGVMKGVPSSRDYNGGFASKLMAKDLNLAAASAEEVGHKSPLISKAQEIYKKMCEEGHETKDFSCVFRHFYNGKDEV
Protein: SH3 domain-containing protein Dlish (Dachs ligand with SH3 domains) (A1ZAY1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the apical cell cortex localization, total cellular level and full activity of dachs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27692068}. Cytoplasm, cell cortex {ECO:0000269|PubMed:27692068}. Note=Low levels are found diffusely in the cytoplasm with high levels concentrated at the subapical cell cortex. {ECO:0000269|PubMed:27692068}.
Interaction partners:
- Dachs, isoform E
- F-box and leucine-rich repeat protein 7
- Palmitoyltransferase app
- Protein limb expression 1 homolog
- Discs overgrown protein kinase
- Protein expanded
Sequence:
MAFLCPVRMRRDKKKATNASIERDLPAVGVLGMGRITGSSSIETLVRVGIEKEHGLSPDSKMVVLHDFTPCVDDELEVKRGQLVNILYRENDWVYVIGQDSRQEGFIPFSYCAPCNTQLADLAVKKKLPREQCPEQPIEENIPLLGTDNKLDVLCDETLNPGSANSIENTLLVEPECTPFVKEPSGRCIVLYTFIARDENDLSVERGEFVTVLNREDPDWFWIMRSDGQEGFVPASFIYPADSVRVLQQQKATLNAMETILQQGQQGQQSQQQQQPQLGLGTDDLRYHGTELVMLYDYKAQAPDDLYLSVRRGDWIYADLTNQTVDGWLWAYAPKTRKYGFIPKAYARPPAMTSL
Protein: Chorismate synthase ARO2 (EC 1.5.1.38) (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphate phospholyase) (Aromatic amino acid requiring protein 2) (P28777)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Pentafunctional AROM polypeptide
- Multifunctional tryptophan biosynthesis protein
- Chorismate mutase
- Anthranilate synthase component 1
- Tryptophan synthase
- Prephenate dehydrogenase [NADP
- Probable prephenate dehydratase
- Anthranilate phosphoribosyltransferase
- Aromatic/aminoadipate aminotransferase 1
- Aminodeoxychorismate synthase
Sequence:
MSTFGKLFRVTTYGESHCKSVGCIVDGVPPGMSLTEADIQPQLTRRRPGQSKLSTPRDEKDRVEIQSGTEFGKTLGTPIAMMIKNEDQRPHDYSDMDKFPRPSHADFTYSEKYGIKASSGGGRASARETIGRVASGAIAEKFLAQNSNVEIVAFVTQIGEIKMNRDSFDPEFQHLLNTITREKVDSMGPIRCPDASVAGLMVKEIEKYRGNKDSIGGVVTCVVRNLPTGLGEPCFDKLEAMLAHAMLSIPASKGFEIGSGFQGVSVPGSKHNDPFYFEKETNRLRTKTNNSGGVQGGISNGENIYFSVPFKSVATISQEQKTATYDGEEGILAAKGRHDPAVTPRAIPIVEAMTALVLADALLIQKARDFSRSVVH
Protein: Cyclic dehypoxanthine futalosine synthase (Cyclic DHFL synthase) (EC 1.21.98.1) (Dehypoxanthine futalosine cyclase) (DHFL cyclase) (Menaquinone biosynthetic enzyme MqnC) (Q727U7)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- 1,4-dihydroxy-6-naphtoate synthase
- Futalosine hydrolase
- Chorismate dehydratase
- Aminodeoxyfutalosine synthase
- 4-hydroxybenzoate polyprenyltransferase
- Thiazole synthase
- 3-octaprenyl-4-hydroxybenzoate carboxy-lyase family protein
- Response regulator
- Flagellar basal body rod protein FlgB
- Anti-sigma factor, putative
Sequence:
MSQHPVAGTQSPFMEADAVRTIAAHVLSGGRIDRAGAETLYHEASLHTLAHLAHAVRLRRHPEPVVTYVADRNINYSNICVCACRFCAFYRAPGAEGGYVLSREELARKIDETLVLGGTQILLQGGHHPDLPLHFYEDMIGWIRATYPAIHIHAFSPPEIVFFAEKEHLTIGEVIERLRAAGLDSIPGGGAEILVDEVRTKVSPNKCSAELWLAVMEEAHYQGLRTTATMMFGHEETHAHRLDHLFAVRDVQDRTGGFTAFIPWTFQPANTAIDRDPEPAPAYLRLLALSRIVLDNIDNIQASWVTMGPHVAQLALFYGANDFGSLMIEENVVAAAGVSFSLSRGEIHKIIRAAGFTPVQRTMDYTPVVPQPVEA
Protein: Large ribosomal subunit protein eL38 (60S ribosomal protein L38) (A0A1D8PG16)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:35613268}.
Interaction partners:
- Small ribosomal subunit protein eS8
- Large ribosomal subunit protein eL30
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL14
- Ubiquitin-ribosomal protein eS31 fusion protein
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL4
Sequence:
MAREIKDIKEFVELARRSDIKSAIVKVNAKVNANGKKFKQTKFKVRGSRYQYTLVVNDASKAKKLQQSLPPTLKITNL
Protein: UBX domain-containing protein 6 (P47049)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.
Interaction partners:
- UBX domain-containing protein 5
- Cell division control protein 48
- UBX domain-containing protein 4
- UBX domain-containing protein 2
- SWI5-dependent HO expression protein 2
- UBX domain-containing protein 3
Sequence:
MYEMSGIDSLFHDRVVHDYSHTSEQVIVVYISSAAGDNSWLHQWFKPGNLSDEERENILWVRLVNGTKECLLFKSIFPSSSAPSINILQNGLLECSIQGNSLSREQDPWETFINGLQSVFKGQVTKRKLFSKSNEEYQRVKRMIQNDKLERKYVFQNTNDPQRKPQKWKQLTVTDNVSYKSQKGFLAQNYCTLQLKLPNGYTISNTFPPQTKLHKVRMWLDYNCYDDGTPYLFHRNIPRVTLTRNDELKSLQELDLLPRSTLILEPLEANNKTFDYMEQSSLLHKVYSGLTSFWAKEPEVDASSSRLGYQRLGTNVSNSANYSLQKLSSLDMVSDGGGGGGGDSMTPSAYTTPRMYPSNGTSQLRQNVSELNLSSNNSASNTKVRTLGYSNNNGNN
Protein: Non-specific lipid-transfer protein 1 (LTP 1) (Q42589)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:8220451}.
Interaction partners:
- Non-specific lipid-transfer protein 13
- Non-specific lipid transfer protein GPI-anchored 1
- Non-specific lipid-transfer protein 9
- Cytomegalovirus UL139 protein
- Putative lipid-transfer protein DIR1
- Non-specific lipid-transfer protein 15
Sequence:
MAGVMKLACLLLACMIVAGPITSNAALSCGSVNSNLAACIGYVLQGGVIPPACCSGVKNLNSIAKTTPDRQQACNCIQGAARALGSGLNAGRAAGIPKACGVNIPYKISTSTNCKTVR
Protein: T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86) (P42081)
Organism: Homo sapiens (Human)
Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Interaction partners:
- Cytotoxic T-lymphocyte protein 4
- T-cell-specific surface glycoprotein CD28
- T-lymphocyte activation antigen CD80
- CD40 ligand
- Programmed cell death protein 1
- Inducible T-cell costimulator
- CD27 antigen
- Tumor necrosis factor receptor superfamily member 4
- Tumor necrosis factor receptor superfamily member 5
- CD276 antigen
Sequence:
MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF
Protein: UPF0612 protein P20C8.01c (Q9HDT8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MMSNENFDNDYNLPPPNDSAEDLKIFIKRYERSVDSTLLEIDENKREALEKYIEERDRKMKYEIECNERLQGWKKLAIEREISEEQSGEVQFPRWIDEWANTKLGGIFERIFSKMDSMQNDMNSRFDAMQNEMNSRFDTVQNEMTSMKGEMAEMKVEMVEMKRETIRLNTRIDLLEQKTEARFQSIEQRFNSIDQRFNSIDRRFDSMEQRLDSMDQKMETIDARSCRSIMLTRKLENTTRSDQGYLA
Protein: Neutral sphingomyelinase activation associated factor (A0A8I6A334)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRMMRARLSGCPSGYILQESLVYFIKEHNIVAPYKIERGKMEYVFQLEVSGKVEDVVETLLQLHRASCLDKLGDQMAMITAILQSRLARTSFDKNRFQSVSEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWVISDYSSPELDLSNPATFRDLSKPVGALNPERLERLLTRYQEMPEPKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYDEDASFLINSLKLDLGKRQGGQMVDDVELPAWASSPQDFLQKNKDALESSYVSEHLHEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDDKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQASSYNASMTDSPVSPGEESFEDLTEESKTLAWNNITKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHNDRLYSASWDSTVKVWSGVPAEMPGTKRHQFDLLAELEHDVSVNTINLNAVSTLLVSGTKEGLVNIWDLTTATLLHQISCHSGTVCDAAFSPDSRHVLSTGVDGCLNVIDVQTGMLISSMASEEPQRCFVWDGNSVLSGSRTGELLVWDLLGAKVSERIQGHTGAVTCIWMNEQCSSIITGGEDRQVMFWKLQY
Protein: Decorin (Bone proteoglycan II) (PG-S2) (Q9XSD9)
Organism: Sus scrofa (Pig)
Function: May affect the rate of fibrils formation.
Subcellular location: Secreted, extracellular space, extracellular matrix. Secreted {ECO:0000250|UniProtKB:P07585}.
Interaction partners:
- Transforming growth factor beta-1 proprotein
- Insulin-like growth factor 1
- Receptor protein-tyrosine kinase
- Toll-like receptor 4
- Transforming growth factor beta-3 proprotein
- Transforming growth factor beta-2 proprotein
- Toll-like receptor 2
- Uncharacterized protein.
- Hepatocyte growth factor receptor
- Lumican
Sequence:
MKATIVFLLLAQVSWAGPFQQKGLFDFMLEDEASGIGPEDRFPEVPELEPLGPMCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKAVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKISKVDAASLKGLNNLAKLGLGFNSISTVDNGSLANTPHLRELHLNNNKLNKVPGGLAEHKYIQVVYLHNNNISAVGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
Protein: Insulin gene enhancer protein ISL-2 (Islet-2) (Q9CXV0)
Organism: Mus musculus (Mouse)
Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- LIM/homeobox protein Lhx3
- LIM/homeobox protein Lhx4
- Motor neuron and pancreas homeobox protein 1
Sequence:
MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAQCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPSLRTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKASLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET
Protein: Capsid assembly scaffolding protein (Gene product 7) (gp7) (Head morphogenesis protein) (Protein p7) (Scaffold protein) (P13848)
Organism: Bacillus phage phi29 (Bacteriophage phi-29)
Function: Scaffolding protein involved in the icosahedric procapsid assembly. Coassembles with the capsid proteins to form the procapsid. The scaffolding protein is found within the capsid as a serie of concentric shells. During DNA packaging, the scaffolding protein molecules are released from the procapsid.
Subcellular location: Note=Present in about 147 copies in the prohead but not present in mature virions. {ECO:0000269|PubMed:11562162}.
Interaction partners:
Sequence:
MPLKPEEHEDILNKLLDPELAQSERTEALQQLRVNYGSFVSEYNDLTKSHEKLAAEKDDLIVSNSKLFRQIGLTDKQEEDHKKADISETITIEDLEAK
Protein: Homeobox protein MIXL1 (Mix paired-like homeobox) (Q5TYX1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- SRY-box transcription factor 32.
- T-box transcription factor T-A
- Eomesa protein
- T-box transcription factor Tb.
- SRY-box containing gene 17
- Forkhead box protein H1
- GATA-binding protein 5
- Mothers against decapentaplegic homolog 2
- Nodal-related 1.
- Forkhead box protein A2
Sequence:
MAVVHGNLGNGHLKQFQLFPNADMERRTGMHTSDYVLQDRMKFLDGASRADNVSLFTHRRKRTNFTQQQIDVLEKVYLDTKYPDIYLREKLEALTGLPESRIQVWFQNRRAKSRRQVGISIPNKTSGNILTPNNLLMHQFTTHQNHSGLENLQRTSTFTADSFHQQLINSSEEKISTIKGDIYDPTTIPCMFSRTQENPIKTDHLSVVVPRSYTQQYPKEHEQFTHSANHAKSTMKQFLVEYDNFPPNKTIGPEMKVVIPPLPSQSNFMMSSSSPKHIACSVQNMSVQTQPELFATFSPIRASEAVEFSDSDSDWERDAMSGFNGFI
Protein: Cytochrome P450 711A1 (EC 1.14.-.-) (Protein MORE AXILLARY BRANCHES 1) (B9DFU2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Converts carlactone to carlactonoic acid by catalyzing consecutive oxidations at C-19 to convert the C-19 methyl group into carboxylic acid. Prefers 11R-carlactone to 11S-carlactone as substrate. Acts downstream of CCD7/MAX3 and CCD8/MAX4 in strigolactone signaling pathway and may be implicated in synthesis of carotenoid-derived branch regulators. Acts as a positive regulator of the flavonoid pathway in the late vegetative stage plant. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Carotenoid cleavage dioxygenase 8, chloroplastic
- Carotenoid cleavage dioxygenase 7, chloroplastic
- F-box protein MAX2
- Beta-carotene isomerase D27, chloroplastic
- Strigolactone esterase D14
- Protein RADIALIS-like 2
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 6
- Protein HEAT STRESS TOLERANT DWD 1
- Protein RADIALIS-like 5
Sequence:
MKTQHQWWEVLDPFLTQHEALIAFLTFAAVVIVIYLYRPSWSVCNVPGPTAMPLVGHLPLMAKYGPDVFSVLAKQYGPIFRFQMGRQPLIIIAEAELCREVGIKKFKDLPNRSIPSPISASPLHKKGLFFTRDKRWSKMRNTILSLYQPSHLTSLIPTMHSFITSATHNLDSKPRDIVFSNLFLKLTTDIIGQAAFGVDFGLSGKKPIKDVEVTDFINQHVYSTTQLKMDLSGSLSIILGLLIPILQEPFRQVLKRIPGTMDWRVEKTNARLSGQLNEIVSKRAKEAETDSKDFLSLILKARESDPFAKNIFTSDYISAVTYEHLLAGSATTAFTLSSVLYLVSGHLDVEKRLLQEIDGFGNRDLIPTAHDLQHKFPYLDQVIKEAMRFYMVSPLVARETAKEVEIGGYLLPKGTWVWLALGVLAKDPKNFPEPEKFKPERFDPNGEEEKHRHPYAFIPFGIGPRACVGQRFALQEIKLTLLHLYRNYIFRHSLEMEIPLQLDYGIILSFKNGVKLRTIKRF
Protein: Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (MNat2) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) (Q8K2P7)
Organism: Mus musculus (Mouse)
Function: Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient. Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis. May also contributes to amino acid transport in placental trophoblast (By similarity). Regulates synaptic plasticity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27655909}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JM15}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain. {ECO:0000250|UniProtKB:Q9JM15}.
Interaction partners:
- Sodium-coupled neutral amino acid symporter 2
- Neutral amino acid transporter B
- Large neutral amino acids transporter small subunit 1
Sequence:
MMHFKSGLELTELQNMTVPEDDNVSNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKRKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLILLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTGAMLSYLFIVKNELPSAIKSLMGEEDAFSAWYVDGRVLVVMVTFGIILPLCLLKNLGYLGYTSGFSLSCMMFFLIVVIYKKFQTPCMSVEQNSTVSANVTDACTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYEKVQSDLLHKYQSTGDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFHLCRHVLVTIILLIIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITNQDGDKGTQRIWAALFLGLGVLFSLISIPLVIYDWACSSGTDEGH