wanglab/gogpt-training-data huggingface dataset:
Protein: CIN85 and CD2AP related, isoform G (A0A0B4KHG1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLPPKPQREFCRVEFPYAPQNDDELELKVDDIIAVISTELPDKGWWKGEIRGKVGVFPDNFVKMLAPSEATAAPPLPRPRPRTRPGMGGTGAGSGSGIIDGVRTPRRTQRGGSFEFLGARMASFITTIFAPINEPPSATQITQNQRKVSNTASTTSHMTTTNSSNSSTTSVTTQQQKEQIGGSSSTTSKVYIKKTGSSSNSTTSSTTTASSSAGRKESFGSRDSLNDILSETGLPTGNVAAQRKSLENKNLDLTKPPGVGASVSIGQQRSSTSSATTSSATTVATGLTSSSVSKSMENMLDEKVKSPPPPVLSKKPSVPLKKTPTGGVPMTGNLLGGKKKNTEGKLTTAVSHDLADGLAASKMLSGANQLPESGAAGNVVIRRAATIAVEDTDFDRVERASILTDMRQGRVKAPKRRPPSAAINVLGESNNNSVYVNGSGMSGSGGAGSASELSEDGGAGGKTSDDNSTGEEPQLAKPKPREWEKKKAPWMEELKASQVTRKKTSPSVEPRGASVAERTSKLFAAEQAVSSNSSSITTKVQSSAVTSSMFVENSTTSSSVITSSSHTTTNDAIMSRSLSAAKVQTASSDEETRATRPNSLAIRNQRSVSPLVKSSNASSSQSQEEKPTSQLNNHQDASSSRVAQLEQRVDKLEGLVLNQQRTIEELVNALKSEAERVKILRSELDKYAQCVTQV
Protein: Protocadherin 17 (E9PXF0)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGKDARLQPGLPPAERGSGSGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFPSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFALDVKSRGDGTKFPELVIQKALDRELQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGLGGPGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAVKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNYEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNSSETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECINCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRALSPLLQEVPSASSSPTKACIEPCASTKGSLDGCEAKPGPLAEASSSYLPTDSQYPSPSKQPRDPSFMASDQMARVFADVHSRARRASSEMGAVLEQLEQPNRDLGRESVDAEEVVREIDKLLQDCRGNDPVAVRK
Protein: Natriuretic peptide PNP (P82972)
Organism: Pseudocerastes persicus (Persian horned viper) (False horned viper)
Function: Increases urine flow and decreases blood pressure when administered to rats by intravenous injection. Inhibits thrombin-induced platelet aggregation. Stimulates cGMP production via the natriuretic peptide receptor-A (NPR1).
Subcellular location: Secreted {ECO:0000269|PubMed:14741349}.
Interaction partners:
Sequence:
GENEPPKKKAPDGCFGHKIDRIGSHSGLGCNKFKPGH
Protein: Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) (Q62910)
Organism: Rattus norvegicus (Rat)
Function: Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (By similarity). Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity).
Subcellular location: [Isoform 1]: Membrane {ECO:0000269|PubMed:8798761}.; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O18964}.
Interaction partners:
- Endophilin-A1
- Amphiphysin
- Myc box-dependent-interacting protein 1
- Endophilin-A2
- Epidermal growth factor receptor pathway substrate 15
- Endophilin-A3
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Inositol polyphosphate-4-phosphatase type I A
- Clathrin heavy chain 1
- Phosphatidylinositol-3-phosphatase SAC1
Sequence:
MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYAKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRVDASDEDRISEVRKVLNSGNFYFAWSASGVSLDLSLNAHRSMQEHTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVIYLDDCVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKDLYGKQIVVNLLGSKEGEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFDGSAVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKNMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVNASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFVEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSEDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQKIYKEVIAVQGPPDGTVLVSIKSSAQENTFFDDALIDELLQQFAHFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITITLKSPDWIKTLEEEMSLEKISVTLPSSTSSTLLGEDAEVSADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTAPEYSAPSLPIRPSRAPSRTPGPLSSQGAPVDTQPAAQKESSQTIEPKRPPPPRPVAPPARPAPPQRPPPPSGARSPAPARKEFGGVGAPPSPGVTRREMEAPKSPGTARKDNIGRNQPSPQAGLAGPGPSGYGAARPTIPARAGVISAPQSQARVSAGRLTPESQSKPLETSKGPAVLPEPLKPQAAFPPQPSLPTPAQKLQDPLVPIAAPMPPSIPQSNLETPPLPPPRSRSSQSLPSDSSPQLQQEQPTGQQVKINGACGVKQEPTLKSDPFEDLSLSVLAVSKAQPSAQISPVLTPDPKMLIQLPSASQSKVNSLSSVSCMLTMPPVPEQSKSQESVGSSANPFPSLPTRNPFTDRTAAPGNPFRVQSQESEATSWLSKEEPVSNSPFPPLMPLSHDMSKPSSSLDGFEDNFDLQSQSTVKTSNPKGWVTFDEDEDFPTKGKSRSVYPDSLGNTAASFDDDWSKGTNVSFCVLPARRPPPPPPPVPLLPPGTTSSAGPSTTLSSKASPTLDFTER
Protein: 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (5-HT-2F) (NP75 protein) (Serotonin receptor 2B) (Q02152)
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and downstream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1426253, ECO:0000269|PubMed:17325130}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41595}. Synapse, synaptosome {ECO:0000269|PubMed:18337424}.
Interaction partners:
- Guanine nucleotide-binding protein G
- 5-hydroxytryptamine receptor 2C
- 5-hydroxytryptamine receptor 2A
- 5-hydroxytryptamine receptor 1B
- Guanine nucleotide-binding protein subunit alpha-11
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Voltage-dependent L-type calcium channel subunit alpha-1F
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Basigin
Sequence:
MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
Protein: Emb|CAB53482.1 (Late embryogenesis abundant protein, group 2) (Q9FMN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MHAKTDSEVTSLSASSPTRSPRRPAYFVQSPSRDSHDGEKTATSFHSTPVLTSPMGSPPHSHSSSSRFSKINGSKRKGHAGEKQFAMIEEEGLLDDGDREQEALPRRCYVLAFIVGFSLLFAFFSLILYAAAKPQKPKISVKSITFEQLKVQAGQDAGGIGTDMITMNATLRMLYRNTGTFFGVHVTSSPIDLSFSQITIGSGSIKKFYQSRKSQRTVVVNVLGDKIPLYGSGSTLVPPPPPAPIPKPKKKKGPIVIVEPPAPPAPVPMRLNFTVRSRAYVLGKLVQPKFYKRIVCLINFEHKKLSKHIPITNNCTVTSI
Protein: Tyrosine-protein phosphatase non-receptor type 61F (EC 3.1.3.48) (dPTP61F) (Q9W0G1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state.
Subcellular location: [Isoform A]: Cytoplasm. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Endomembrane system. Note=Associates with the membranes of the reticular network and the mitochondria.; SUBCELLULAR LOCATION: [Isoform B]: Nucleus.
Interaction partners:
- Insulin-like receptor
- Signal transducer and transcription activator
- Tyrosine-protein kinase hopscotch
- Dreadlocks, isoform B
- Suppressor of cytokine signaling at 36E, isoform D
- 6-pyruvoyl tetrahydrobiopterin synthase
- Cytokine receptor
- Tyrosine-protein kinase Abl
Sequence:
MSEQKTSGSGSAAAARLQIEAEYKDKGPQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTETHTLDELPPPLPPRVQSLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDAEVADSRPLPPLPVRAFNDSDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHADDVNANNEKPAVPVDEQHKANGIDPIPGQLPASPENELKRRKRNEYQASLEQKVNDMKRKQRENEDKQLAAKKRRSLLTYIAAGVVVGVICAYAYTKLG
Protein: Uncharacterized protein (Q383U2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MESSLGAYCMKEAIRQRQNGYVVPTSVDSYDFHHWEQEARRRCGLIGSQGNQSAFLRKIDCDANLLVDEVAKCGRTGASRNVPHSFGTEHELTAFLSSLEVLLRVFFLDSSNEALLVTLQKFRENFTDLQKKKVIGLEYGKYPEIYVLYELFSLRKLLLNWKGMTPENQKVITRTAMSYMAYVRSPEYAILGDLLGMAEKNLSSVAVNTIKMVKCLDQACGSTPYAFPHICQFVLSSVCPRHSCPSGTLTLKGSATQKGETTGVDTAATADVANPMATEPSHTRKRARNADDVTKGETSTETDDQVAAEKRQQCVSKYHSRYSAARRFASKGCRFCGLCHMMEILFNGCSLVCNSAHGPTEWKISSNLKRYPEVCTLALRRFKAMQRGVVLKPCEDIPLS
Protein: Fructose-bisphosphate aldolase, cytoplasmic isozyme (EC 4.1.2.13) (P08440)
Organism: Zea mays (Maize)
Subcellular location: Cytoplasm.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
Sequence:
MSAYCGKYKDELIKNAAYIGTPGKGILAADESTGTIGKRLSSINVENVEENRRALRELLFCCPGALQYISGVILFEETLYQKTKDGKPFVDVLKEGGVLPGIKVDKGTIEVVGTDKETTTQGHDDLGKRCAKYYEAGARFAKWRAVLKIGPNEPSQLAIDLNAQGLARYAIICQENGLVPIVEPEILVDGPHDIDRCAYVTETVLAACYKALNEHHVLLEGTLLKPNMVTPGSDSKKVTPEVIAEYTVRTLQRTVPAAVPAVLFLSGGQSEEEATRNLNAMNKLSTKKPWSLSFSFGRALQASTLKAWAGKVENLEKARAAFLARCKANSEATLGTYKGDAAADTESLHVKDYKY
Protein: Uncharacterized protein C683.03 (Q96VG3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
Sequence:
MEKCINRYKDILPLNRYSDGSGKCWGLLGCEISSVVGQTGVKRLLLGSITKFVYCSMRLFSLYTIVQYFKSLRCLRNGRTEVRLYTHYKRHLPRSVNSIYLQTNC
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A097PIG6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
RKEEEERRRAEDEKRRVEREQEYIRRQLEEEQRHLEILQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHAQQPPPPQQQDRSKPSYHAPEPKPHYDPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAAKKPEDKKEVFRPLKPADLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEEEDVEQEGADDSTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQSTVDQKRASHHESNGFAGRIHLLPDLLQQSHSSSTSSTSSSPSSSQPTPTMSPQTPQDKLTANETQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGLRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCTIKPHAIIILPNTD
Protein: DNA gyrase subunit A (EC 5.6.2.2) (Q5SIL4)
Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Function: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. It probably also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes. Relaxes negatively supercoiled DNA in an ATP-independent manner. At comparable concentrations T.thermophilus gyrase does not introduce as many negative supercoils into DNA as the E.coli enzyme.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01897}.
Interaction partners:
Sequence:
MAQVLPVEITEELKQSFINYAMSVIVDRALPDVRDGLKPVQRRILFGAYQEGVLPGRKHVKSAKIVGEVMGKYHPHGDAAIYDALVRMAQPWNLRYPLIDGQGNFGSIDGDPPAAQRYTEARLSPIGAEMLLDIDKDTVDFRPNYDGSLKEPEVLPAAIPNLLVNGASGIAVGMATSLPPHNLSEVVDALVAMIENPAITLEEVMRHLPGPDFPTGGKLSKKGIKEAYATGRGSLKVRAKVRVEEKGQRPVLVVTEIPYQVNKASLIAQIAALVKAKKIEDIVGLRDESDRQGLRIAIELKRGANPQVVLNQLYKHTALQTSFTVNLLAIVDGEPKVLSLLDLMRHYLDHRKEVVRRRSLFELRKAEERAHVLEGLLIALDHIDEVIALIRGSEDAPKARIALMERFGLSEAQAQAILDMRLQRLVALEREKLLEEYRGLMEEIARLKAILEDEARLLAEVKADLLRVKEKYGDARRTLITEFEETFNPEDLIEDEPMVITLTAQGFLKRLPLESYRAQGRGGKGLLAGRTKEEDEATHVFVADAHDDLLLFTNRGRVYRLKVYELPEMGRQARGVHVKSLLPLAEDEEVAALLSVRGLDQEGYLVFATERGLVKRTALKEYQNLGQAGLIAIRLQEGDRLVGVALSDPEDEAILATQEGQAIRFPLEEVRATGRDTQGVIGVRFKKPEDRVVSLVVVKPGEMVDLLSVSTRGYGKRTPLSEYPLQGRGGMGVITYAVSTKVGRLAALLKVRGGEDLLVLSRRGLAIRTPVAEIRQYSRATAGVRVMNLPEDDEVASAFVVEEEK
Protein: Mite allergen Blo t 21 (Mite group 21 allergen Blo t 21) (allergen Blo t 21) (A7IZE9)
Organism: Blomia tropicalis (Mite)
Interaction partners:
Sequence:
MKFIIALAALIAVACALPVSNDNFRHEFDHMIVNTATQRFHEIEKFLLHITHEVDDLEKTGNKDEKARLLRELTVSEAFIEGSRGYFQRELKRTDLDLLEKFNFEAALATGDLLLKDLKALQKRVQDSE
Protein: X11L, isoform E (M9PF12)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNSNSCSDSSNESMVNPPHIQMNFGQQAQQQQSHQHQQQQQQQERYVWEMRTRSPNVTPASTVLNSPDLNGELSYVPLQGLSPSGGGVQGSGSYGSNAGRDSGSYYYQRPQLHQIRLGRSPGSQFETRDVLPQGLASPGSPTDVGKADGQCLRDGEIVVFDDIDTNWMNKASSGQRPGSNEDVLKVTKMIGQLPIAEYEGSPRRFGSQPNTNTITMGGPRKRPPGFPQRVSPTTSVANNATAAAKASVGNLIDLVDHEEERSGTLREKTPTFDYLYEFSETRKVLEEFFKANPEDEKRYTDYTTESGDDVASSQPQEYPATPMEQAYIGQRLARIPKDELYMVHRSPTKKPPSDQNPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSRNFTLSPETTDYDSNCGDLDSLSNDINCPTDFGKLYTSMPVLEDGLSSGHASDTENNVSVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDASQSALISDFASLPMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATIRQGIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRNKEVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKAPEGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQLIAINGMSLVGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEVKILRPKALFQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHDTIVKLLSSSVGEILMKTMPTSMFRLLTGQETPIYI
Protein: GRB2-associated-binding protein 1 (F1Q7S5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Growth factor receptor-bound protein 2
- Growth factor receptor-bound protein 2a
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 3-kinase regulatory subunit beta)
- Phosphoinositide-3-kinase, regulatory subunit, polypeptide 3
- Tyrosine-protein phosphatase non-receptor type
- Hepatocyte growth factor receptor
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- phosphatidylinositol-4,5-bisphosphate 3-kinase
Sequence:
MSGGDVVYSGWLRKSPPEKKLRRYAWKKRWFVLRSGRLSGDPDVLEYYKNDHAKKPIRVIDLNLCEQVDAGLSFNKKDLEHSFIFDIKTIDRIFYLVAETEEDMNKWVRNICEICGFNPTDTEDSAKVSHHVNVPGGLVVDMAPSGGLGGALGASALANLPPPYQPVSIRQLGSSSSLDEPQDYLWLLNCESKKPEPNRAHGDCSKSTSSEPDCNDNLPSHYTPTSSTSKNAPVNGFFSTQHPTGLYDSPPLRGQSLSADSQGLYHLPRSYSQDTVLLPKSATSPPIPDGEPGELYVFNTPGRKPSLEAHLRNLSVSYDIPPTPGSNSTYQVPRTAGVEAVSGSTEVIPPPRPPKPSVSGGSVPPERSPTDTYVVPRSVSETDTNYCVPTSAGGNKALRSNTIGTVDSSRLRKDYGSQDCYDIPRPFPSEKSCSFDFNESFNNYFKNKGMVPVGGVSTEEMDENYVPMSVHSLSHQRSGSLSEPIQEPNYVPMTPGTVEFSSLGKQVPPPAHMGFRSSPKTPPRRPIPISECQPPPIDRNLKPDRKGQSPKINRAVGLERTDSQTIGEFSRRRKVKPAPLEIKPVSEWEEYTAPVRSPVTRSFTRDPSRFTVAPRPSSGQSTASSSDSDECDENYVTMQANMSSDEPNKLGAPMNADGGGSPMVKPKGDKQVEYLDLDLDPGKSTPPRKKKNNGTGISASDERVDYVLVDQQRTQALKSTREAWSDGRQSTEDTPTKGAK
Protein: ABC1 family protein MCP2 (MDM10-complementing protein 2) (MIOREX complex component 13) (Mitochondrial organization of gene expression protein 13) (Q06567)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression. Involved in mitochondrial lipid homeostasis.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961}. Mitochondrion inner membrane {ECO:0000269|PubMed:23781023}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial adapter protein MCP1
- Mitochondrial distribution and morphology protein 12
- Mitochondrial distribution and morphology protein 10
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Mitochondrial Rho GTPase 1
- Mitochondrial distribution and morphology protein 34
- ABC1 family protein YPL109C
Sequence:
MMTKAFFNKLPFEVFRRYVRTGKSIPQRSPRTRKSLLVGGTIASAVVLYNFNDTFHDSVKHTALTTKRIAVVTQATTRCFYHYKRALNKSYENKKEREVALNKCHKMCALITLHALRSNGGIYIKLGQHIGAMTYLLPKEWTDTMIPLQDHCPESTYEEIDELFKEDLGTSIEDMFLEFNKTPIGVASLAQVHVAKLKNSDGKGSSVAVKCQHPSLKEFIPLDVMLTRTVFELLDVFFPDYPLTWLGDELQSSIYVELNFTKEAENAEKTRHYFSKFKKQTALKIPKVIESHKRILIMEYVGGKRLDDLEYIDSHGISRSEVSSCLSHIFNNMIFTPNVGIHCDPHGGNLAIRSVKPAKDNGYHNFEIVLFDHGLYRYPSTRTRRLYAKFWLSLLFDKDQTKMKKYAKGFANITDEQFPLLAAAITGRSIDAALNYDISTSRTQEEMDVMANGILEGTLLSDLMSILSRIPRVVLLILKTNDLTRHLDECLQNPLGPERTFLIMTQYCAKTVYDEKVERINSEYARWSIKWMWENLTNWIVYERRINQLYFYDFVLWWKKFIPKTWLSS
Protein: Pectin lyase A (PLA) (EC 4.2.2.10) (Q5BAU9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Rhamnogalacturonase A
- Beta-mannosidase B
- Beta-mannosidase A
Sequence:
MKTTFLVSLATAALSSTAAAVSVSGSAEGFAKGVTGGGSATAVYPDTIDELVSYLGDDEARVIVLSKTFDFTDSEGTTTETGCAPWGTDAACQVAINQNDWCTNYQPDAPSVSVTYDNAGTLGITVNSDKTLIGEGSAGVIKGKGLRLVSGTSNVIIQNIAITDINPKYVWGGDAITLNDVDMVWIDHVTTARIARQHIVLGTEADNRVTISNSFINGESDYSATCDGYHYWGIYLDGSSDMVTMKGNYIYHTSGRSPKVQGNTLLHAVNNYWHDNSDHAFEIGEGAYVLAEGNVFQNIPTVAEDPIEGELFASPSESANEVCSTYLGRVCELNGFGSSGTFNQADTDFLSKFEGKNIASADSYSSVASSVASSAGNTL
Protein: NAC domain-containing protein 60 (ANAC060) (Protein NTM1-like 5) (Q9LXL9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (By similarity). Transcription factor involved in modulation of abscisic acid (ABA) signaling. Attenuates ABA sensitivity and glucose-induced ABA accumulation. Reduces the expression of ABI4 gene.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q949N0}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:24625790}. Note=Localized primarily in plasma membrane or endoplasmic reticulum membrane as dormant form and, upon specific stress or signal, is processed into a transcriptionally active and nuclear form after a proteolytic cleavage through regulated intramembrane proteolysis (RIP). {ECO:0000250|UniProtKB:Q949N0}.
Interaction partners:
- glucan endo-1,3-beta-D-glucosidase
Sequence:
MAAAPPIEPAVTTTFPGFKFSPTDIELISYYLKRKMDGLERSVEIIPEVEIYNFEPWDLPDKSIVKSDSEWFFFCARGKKYPHGSQNRRATKIGYWKATGKERNVKSGSEVIGTKRTLVFHIGRAPKGGRTEWLMHEYCMIGVSLDALVICRLRRNTEFQGSTIQKPPQPSLPLDKHVNLRNEAISESIYGWETMVDFYLSSESGQELLSEIAESSQSSQNPQVPSEEDFYADILRDEIVKLDDPAVSGNTLINVPRLQTESNTTRVLPLPDMVDKQMQSLLQKLPLQNDTGEENNISMSNCFIGIYSIKSINRARWDVVVWLLVMIAVLVFYLV
Protein: Phosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (Phospholipid methyltransferase) (PLMT) (Q61907)
Organism: Mus musculus (Mouse)
Function: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure (Probable). Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UBM1}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Mitochondrion membrane {ECO:0000255|HAMAP-Rule:MF_03216}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000250|UniProtKB:Q9UBM1}.
Interaction partners:
- Choline/ethanolaminephosphotransferase 1
- Phosphatidylserine decarboxylase proenzyme, mitochondrial
- Phosphatidylserine synthase 2
- Ethanolaminephosphotransferase 1
- Phosphatidylserine synthase 1
- Cholinephosphotransferase 1
- Phosphatidylcholine-sterol acyltransferase
- Choline dehydrogenase, mitochondrial
- Membrane-bound glycerophospholipid O-acyltransferase 2
- Lysophosphatidylcholine acyltransferase 2
Sequence:
MSWLLGYMDPTEPSFVAAVITIVFNPLFWNVVARWEQRTRKLSRAFGSPHLACYSLGICILLLNILRSHCFTQAMMSQPKMEGLDNHTTYFLGLAFLGWGFVFVLSSFYALGFTGTFLGDYFGILKESRVTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVLVAIVYVVALLYEEPFTAEIYRQKATRLHKRS
Protein: Fos-related antigen 2 (FRA-2) (P51145)
Organism: Rattus norvegicus (Rat)
Function: Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:15299028}.
Interaction partners:
Sequence:
MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSGSAFIPTINAITTSQDLQWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGVIKTIGTTVGRRRRDEQLSPEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEKEKLEFMLVAHGPVCKISPEERRSPPTSGLQSLRGTGSAVGPVVVKQEPPEEDSPSSSAGMDKTQRSVIKPISIAGGGFYGEEPLHTPIVVTSTPAITPGTSNLVFTYPSVLEQESPASPSESCSKAHRRSSSSGDQSSDSLNSPTLLAL
Protein: F28J7.36 protein (NAD(P)-binding Rossmann-fold superfamily protein) (Q9SGI2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pentatricopeptide repeat-containing protein At1g76280
- Embryo defective 2739
- Beta-adaptin-like protein A
- GPI ethanolamine phosphate transferase 1
- Protein REDUCED CHLOROPLAST COVERAGE 1
- 65-kDa microtubule-associated protein 5
- Probable acyl-activating enzyme 12, peroxisomal
- Vacuolar sorting protein 3
- Alpha-barbatene synthase
- Ras-related small GTP-binding family protein
Sequence:
MENPAKRVLMTSNGDEVSRNIAFHLAKHGCKLVMMGNEGSLRSIVDKIRDSIEGAFPADVIALDMESDSEVAFHAAVQKAWELSGHFDAFLNSYTYQGLICFLFFTTLPLMLLCVDHSFIQQSFFLAGKVQDILQVSQDEFHRITKINLTAPWFLLKAVATRMKDHGSGGSIVFMATIASGERALYPGADAYASTSAAIHQLVRASAMSLGKHKIRVNMISRGLHLDDEYTASVGRDRAQKLVKDAAPLGQWLNPDTDLYSTVIYLISDGSRFMTGTTVLVDGAQSLTRPRLKSYM