wanglab/gogpt-training-data huggingface dataset:
Protein: Probable 3',5'-cyclic phosphodiesterase pde-2 (EC 3.1.4.17) (P30645)
Organism: Caenorhabditis elegans
Function: May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size.
Interaction partners:
- GMP reductase
- Receptor-type guanylate cyclase gcy-12
- adenylate cyclase
- Adenylosuccinate lyase
- Adenylate kinase
- Probable adenylate kinase isoenzyme ZK673.2
- Adenosine kinase
- AMP deaminase
- Receptor-type guanylate cyclase gcy-8
- Putative cytosolic 5'-nucleotidase 3
Sequence:
MLELRRNSSPSSAHPSPQTNCQNSQRGDGLHHHHHEAASGSTCCGGMTVFTGANAAKSSNEPAGSASPTVWRKTSHPPLHFNNNETRNRNLQMQLKNRGTKDDWGASLRYDIEEPTSSGLLELLPDVPIVRKLSRPLVKMDDQDDACSVASNESDRTVLSPLVPMSIFDQFLCLTNNLSALISCIIAEAKKNTEAEDYAVFLHDEDNKQMVLFNNETMLMTGKKFDMGYGIVGKVASTMRTMNIRDVSRCPFFNEEIDEQFSIKARNLIAFPLIDSSCSLIGVIVLYNKENGFSRHDEKYIKRFSYFVANSIAHAILAKQIEEVRTRIHMVEEFKIQGEDAVIEEVDIMRLVNDPLRDWRYFSQNFADFSFPPRSVGENHFHRASMMFFEDLGFSMLYKLNKRKLSYLVLRVSAGYRPVPYHNWSHAFAVTHFCWLTLRTDAIRRALSDMERLSLLIACLCHDIDHRGTTNSFQMQSLQKTPLSVLYSTEGSVLERHHFAQTIKLLQQEECSILENLPAADFRTIVNTIREVILATDISAHLRKQERIKTMISEGYNPMSFDHRYLLMCLVMTASDLSDQAKNFHNAKRIAENIYLEFFAQGDLELQLGVKPLEMMDRTNAYVPTVQIDFLFKIGVPVFQLLASVVPEGRTTSEAIDANHLCWVALDEEVRNNPSATNTLEYLRDENLERRIYDRVRKQDPRAAEIASKRFEPVYANGSVPQTQDILDHRFDGYDKKYQIGCSGGQNQSNGKQQQIRSLQKIRSKTSEDDALLKPMDNGGSVAASSTRRGSRTPRRLWRRARQLISSMSSSCASCSPLPSRRQVSEDSESC
Protein: LD27656p (Q7K0V7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSGLEYGLHRYDDLPLEIVLKIFSYLGYSDLQAAGSTCQRWHAALDQAEFNQRTRVCFSKVVLSDQLSPGVDLMRCERRFQHFLFEDVTLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLHSLSLKRCLPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHTLIGQALLALCDLNLQLQRLYLAGCRQLNCTTILNFLATQPQLCALDLSATMCVNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKCLKSLDISNCDNLTSSGIIEGIASEENPVIQELNVSYLQICEECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIGQLRWLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSLKYGLKHIELRRLMLSNCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPRLKALHISGCSQLTEHTLDAIITNCSCLQTLSIYRCRSMYTDLEERLSGVKTLRNLNMDNLTSIDNAEFFRLKKRLDY
Protein: ELAV-like protein 3 (Hu-antigen C) (HuC) (Q60900)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Plays a role in the stabilization of GAP43 mRNA and in spatial learning.
Interaction partners:
- RNA binding protein fox-1 homolog 3
- ELAV-like protein 2
- Tubulin beta-3 chain
Sequence:
MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILLDQATGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA
Protein: Lex2B (Lipooligosaccharide biosynthesis protein lex-1 (EC 2.-.-.-)) (C1J7J7)
Organism: Haemophilus influenzae
Interaction partners:
Sequence:
MFITPIFIINLEKSTDRKAYMQAQFEQLFSNNLIQEIHFFDAIYGKSNPNHPLFQRYNENKRLNAKGYPLTLGQLGCYASHYSMWEKCVELDYPIIVLEDDAKFKNNFLEVLDFINSDKNTFEFFWLQPDRLKNKRKLISNFGNLSIYQFSKGFAGTTGYYLTPQAARKFLTQSKEWYLTVDVTMDRFFENKVPPYAIVPFCLEDDGEIESTINEKQKKQRSLKIVIMRELFNLKTNIKRRIYNLFH
Protein: Septin 9 (K7EPY1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLWPEEEPWGGRCACVTEACPADAGPLTSRRGSLKRSFEVEEVETPNSTPPRRVQTPLLRATVASSTQKFQDLGVKNSEPSARHVDSLSQRSPKASLRRVELSGPKAAEPVSRRTELSIDISSKQVENAGAIGPSRFGLKRAEVLGHKTPE
Protein: Glutaredoxin-C9 (AtGrxC9) (Protein ROXY 19) (Q9SGP6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor TGA2
- Transcription factor TGA6
- Regulatory protein NPR1
- Transcription factor TGA5
- Probable WRKY transcription factor 70
- Defensin-like protein 16
- Ethylene-responsive transcription factor ERF094
- Transcription factor MYC2
- Mediator of RNA polymerase II transcription subunit 18
- Protein NIM1-INTERACTING 1
Sequence:
MQGTISCARNYNMTTTVGESLRPLSLKTQGNGERVRMVVEENAVIVIGRRGCCMCHVVRRLLLGLGVNPAVLEIDEEREDEVLSELENIGVQGGGGTVKLPAVYVGGRLFGGLDRVMATHISGELVPILKEVGALWL
Protein: Small ribosomal subunit protein uS2 (30S ribosomal protein S2) (BS1) (Vegetative protein 209) (VEG209) (P21464)
Organism: Bacillus subtilis (strain 168)
Interaction partners:
- Small ribosomal subunit protein uS12
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein bL27
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL2
- Elongation factor Ts
Sequence:
MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQKTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLTNFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDALFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMADAILEAKQGEEEAEVAEETAPETETTTA
Protein: Pyruvate kinase PKM (EC 2.7.1.40) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (P11974)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Subcellular location: [Isoform M2]: Cytoplasm {ECO:0000250|UniProtKB:P14618}. Nucleus {ECO:0000250|UniProtKB:P14618}. Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli. {ECO:0000250|UniProtKB:P14618}.; SUBCELLULAR LOCATION: [Isoform M1]: Cytoplasm {ECO:0000250|UniProtKB:P14618}.
Interaction partners:
- L-lactate dehydrogenase A chain
- Enolase
- Hexokinase-2
- Triosephosphate isomerase
- hexokinase
- Phosphoglycerate kinase
- Beta-enolase
- Fructose-bisphosphate aldolase A
- ATP-dependent 6-phosphofructokinase, platelet type
- Glyceraldehyde-3-phosphate dehydrogenase
Sequence:
MSKSHSEAGSAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELARSSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
Protein: Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)] (P80370)
Organism: Homo sapiens (Human)
Function: May have a role in neuroendocrine differentiation.
Subcellular location: Membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O70534}.
Interaction partners:
- Thyroxine 5-deiodinase
- Retrotransposon-like protein 1
- Insulin-like growth factor 2
- Neurogenic locus notch homolog protein 1
- Zinc finger protein PLAGL1
- Neurogenic locus notch homolog protein 2
- Mesoderm-specific transcript homolog protein
- Insulin-like growth factor-binding protein 1
- Growth factor receptor-bound protein 10
- Cyclin-dependent kinase inhibitor 1C
Sequence:
MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI
Protein: Protein Wnt-4 (dWnt-4) (P40589)
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Acts downstream of homeotic complex genes in the visceral mesoderm and is required for embryonic segmentation. Also required for cell movement and FAK regulation during ovarian morphogenesis.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Frizzled
- Frizzled-2
- Frizzled-3
- Segment polarity protein dishevelled
- Protein wntless
- Low-density lipoprotein receptor-related protein
- Frizzled-4
- Sox100B
- Axin
- Tyrosine-protein kinase-like otk
Sequence:
MPSPTGVFVLMILTHLSFGLGQVRNEDQLLMVGQNGDLDSSNPAIHHQQHQQHQQHQQHQQHQSNHNLNNGNMNSTILNTLMGNNAGQVVNSSPGGGGSMINQLGSSTSSVPSVIGGGVGSVGNPWHSAVGLGVPGNGMGLPSSHGLGGNMGSHPHGHALAGLAKLGIIVPGGQGLPGNLGYGGTMLNGGGVGGAAGMGLGIGSNTNNMDMQQGLYNEHFISEHTVMAVFTSQGQVGGPCRYMPATRRQNHQCRKETGLPGTLSEARRLATTHCEEQFRYDRWNCSIETRGKRNIFKKLYKETAFVHALTAAAMTHSIARACAEGRMTKCSCGPKKHNREAQDFQWGGCNDNLKHGKRVTRSFLDLRGGDGDEVSEILRHDSEVGIEAVSSQMMDKCKCHGVSGSCSMKTCWKKMADFNATATLLRQKYNEAIRKAPNQRSMRQVSSSRMKKPKQRRKKPQQSQYTTLYYLETSPSYCAVTKDRQCLHPDNCGTLCCGRGYTTQVVKQVEKCRCRFNNGRCCQLICDYCQRLENKYFCK
Protein: Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) (P56719)
Organism: Rattus norvegicus (Rat)
Function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O43614}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O43614}.
Interaction partners:
- Hypocretin neuropeptide precursor
- Orexin/Hypocretin receptor type 1
- Oxidation resistance protein 1
- Guanine nucleotide-binding protein G
Sequence:
MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
Protein: Tetrahydromethanopterin S-methyltransferase subunit C (EC 7.2.1.4) (N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit C) (P80185)
Organism: Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Tetrahydromethanopterin S-methyltransferase subunit H
- Tetrahydromethanopterin S-methyltransferase subunit E
- Tetrahydromethanopterin S-methyltransferase subunit B
- Tetrahydromethanopterin S-methyltransferase subunit A 1
- Tetrahydromethanopterin S-methyltransferase subunit D
- Tetrahydromethanopterin S-methyltransferase subunit G
- Tetrahydromethanopterin S-methyltransferase subunit A 2
- Tetrahydromethanopterin S-methyltransferase subunit F
- A-type ATP synthase subunit C
- A-type ATP synthase subunit I
Sequence:
MSVAAGGPAGAAIPESRLMALGILGGLAGIYASAVNPVIGPVLASLGAVCAIVWGADAIRRVASYGLGTGVPSIGYMSVSIGIVGVVAGLASVFVVPAIAVPVVALILAMILGVVVAVLGKKIVKMKIPILEKCTAEISGAAALSVLGFSAAIAGSYTLQTMLTSVITTGFIGLLFILNTMAIQHPFNACLGPNENQTRTLKLAASTGFISMAIVGLLGIGLNPSWWLVSLIGALCWIVAFRAFVSASFEEAASVKWSGLWPKEEEH
Protein: Double-strand break repair protein MRE11 (OsMre11) (Q7XQR9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P49959}. Chromosome {ECO:0000250|UniProtKB:P49959}. Note=Localizes to DNA double-strand breaks (DSBs). {ECO:0000250|UniProtKB:P49959}.
Interaction partners:
- Nibrin homolog
- Os02g0497500 protein
- Os01g0637000 protein
- Os02g0497600 protein
- Os01g0637050 protein
- Exonuclease 1
- ATP-dependent DNA helicase 2 subunit KU70
- Double-strand break repair protein MRE11
- Os05g0463400 protein
- non-specific serine/threonine protein kinase
Sequence:
MGDESNTLRVLVATDCHLGYMEKDEIRRFDSFEAFEEICSLAEQNKVDFVLLGGDLFHENKPSRSTLVKTIEILRRYCLNDQPVKFQVVSDQTINFPNRFGQVNYEDPNFNVGLPVFTIHGNHDDPAGVDNLSAIDILSACNLVNYFGKMDLGGSGVGEIAVYPVLVKKGTTFVALYGLGNIRDERLNRMFQTPHAVQWMRPETQDGMSVSDWFNILVLHQNRIKTNPKSAINEHFLPRFLDFIVWGHEHECLIDPQEVPGMGFHITQPGSSVATSLIDGEAKPKHVLLLEIKGNQYRPTKIPLRSVRPFHYAEVVLKDEVDVDPNDQASVLEHLDKIVRNLIKKSSQPTASRPETKLPLIRIKVDYSGFSTINPQRFGQKYVGKVANPQDILIFSKSAKKRQTTGVGNIDDSEKLRPEELNQQTIEALVAENNLKMEILPVDDLDIALHDFVSKDDKMAFYACLQRNLEETRTKLNSEADKFKIEEEDIIVKVGECMQERVKERSLRSKEDSRFTSSSQNLDTGGRSVTAQSNLNSFSDDEDTREMLLGARTTNAGRKASGFTRPSKDATDVAKTGTSRRGRGRGTASMKQTTLNFSQSRSSAAIRSEEVQSSSDEENETNEANEVVESSEPEESPQQTGRKRAAPRGGRGRGRGATAKRGRKADISSIQSMLMSKDDDDDDEDDRPKKPPPRVTRNYGAVRRR
Protein: Receptor binding protein (RBP) (Gene product 18) (Gp18) (Q71AW2)
Organism: Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)
Function: Binds to the host phosphopolysaccharides at the onset of infection. Upon activation by calcium, the receptor binding proteins change their conformation, presenting their binding sites to the host, and a channel opens at the bottom of the baseplate for DNA ejection.
Subcellular location: Virion {ECO:0000269|PubMed:20351260, ECO:0000269|PubMed:24027307}. Note=Part of the baseplate. {ECO:0000269|PubMed:20351260, ECO:0000269|PubMed:24027307}.
Interaction partners:
Sequence:
MTIKNFTFFSPNSTEFPVGSNNDGKLYMMLTGMDYRTIRRKDWSSPLNTALNVQYTNTSIIAGGRYFELLNETVALKGDSVNYIHANIDLTQTANPVSLSAETANNSNGVDINNGSGVLKVCFDIVTTSGTGVTSTKPIVQTSTLDSISVNDMTVSGSIDVPVQTLTVEAGNGLQLQLTKKNNDLVIVRFFGSVSNIQKGWNMSGTWVDRPFRPAAVQSLVGHFAGRDTSFHIDINPNGSITWWGANIDKTPIATRGNGSYFIK
Protein: Thiamine pathway transporter THI73 (Q07904)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transports either thiamine or, rather, a related metabolite involved in the thiamine biosynthesis pathway.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16850348}; Multi-pass membrane protein {ECO:0000269|PubMed:16850348}. Cell membrane {ECO:0000305|PubMed:16850348}; Multi-pass membrane protein {ECO:0000305|PubMed:16850348}.
Interaction partners:
- Thiamine thiazole synthase
Sequence:
MKNMSQRSMDVEKKAANADSCSVSTSSINVDDADVALRFLKQNGLDESSTANEDDVVAGEEANFYGSHELSPKVLRKVDLFILPFLCCTYLLMFLDKALLNYAASMGIKDHLKGNEFSNLGTIFSAAYIFMEPVVTYLIQKFPISKILGTFITVWGIVLACHAACKTYASLMVVRTLLGLFESSSAVGCIAISGMYYTKSEQSARIGFWATQAGTGYIVGGLISFGFLHYHGTAFTSWQIMFLVVGLVTVAFGVLTFLYLPDNVTNAWFLNKEEKIQVVEHIRANQTGLETKKFKKQQVKELFLHDKFTWPMLLLTACSQISTGAIGTFSVTITGTFGFDKYETALLQLPIGAITAMIILITTQMLSRWGHITLITTSMYIPAIIGCIVLISLPLSHKIGNLFSLYLLYSGSCVITNIYIWNSCNTSGYTKRVFRNAITMIVYNVSCIIAPQMFRAYSAPRYIPAKIALLVTQCVCVPLQLYIGYICKKENEKRDKEQEGQERKKYQFLDLTDIENRNFRYIY
Protein: Chromobox protein homolog hpl-2 (HP1-like heterochromatin protein 2) (G5EDE2)
Organism: Caenorhabditis elegans
Function: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Probably does not act as global transcriptional repressor, instead targeting a subset of genes. Involved in RNA processing mediated by Tar DNA-binding protein homolog tdp-1. Plays a role in linking epigenetic regulation with the innate immune response. Involved in the endoplasmic reticulum (ER) stress response via modulation of the unfolded protein response (UPR), acting mainly through the IRE1-XBP1 pathway and perhaps, to a lesser extent, through the autophagy pathway. May act in a common pathway with retinoblastoma-like protein homolog lin-35 and zinc finger protein lin-13 to influence the ER stress response in the intestine. Plays a role in the formation of the vulva and in fertility, acting together with a CoREST-like complex, and chromobox protein homolog hpl-1. Acting in concert with hpl-1 and histone H1 protein his-24, involved in reproduction, somatic gonad development, male tail development and vulval cell fate specification; perhaps as a result of modulating expression of Hox genes mab-5 and egl-5. In vulval cell fate specification may act by repressing transcription, of EGF family gene lin-3 in hypodermal hyp7, and of homeobox lin-39 in vulval precursor cells (VPC). Role in growth and somatic gonad development is antagonized by histone-lysine N-methyltransferase set-2/SET1. Required for larval development, acting redundantly with hpl-1. Plays a role in regulation of the developmentally arrested larval state known as dauer, longevity, and lipid metabolism.
Subcellular location: Nucleus {ECO:0000269|PubMed:11850401, ECO:0000269|PubMed:16890929, ECO:0000269|PubMed:16905130, ECO:0000269|PubMed:25467431, ECO:0000269|PubMed:26476455, ECO:0000269|PubMed:29760282}. Chromosome {ECO:0000269|PubMed:11850401, ECO:0000269|PubMed:16890929, ECO:0000269|PubMed:16905130, ECO:0000269|PubMed:25467431, ECO:0000269|PubMed:26476455}. Note=Localizes to distinct nuclear foci, not overlapping significantly with hpl-1, in embryonic cells (PubMed:16905130, PubMed:26476455). Localization to nuclear foci overlaps partially with zinc finger protein lin-13 (PubMed:16890929). Localizes to foci in a lin-13-dependent manner (PubMed:16890929). Localization along chromosomal arms correlates with localization of histone H3 methylated at 'Lys-9' (H3K9me), however, hpl-2 can associate with chromatin in an H3K9me-independent manner (PubMed:25467431). Localization on chromosome correlates with sequences enriched in repetitive elements, or in well-expressed genes (PubMed:25467431). Localized to gene bodies (PubMed:29760282). {ECO:0000269|PubMed:16890929, ECO:0000269|PubMed:16905130, ECO:0000269|PubMed:25467431, ECO:0000269|PubMed:26476455, ECO:0000269|PubMed:29760282}.
Interaction partners:
Sequence:
MSSKSTKRAKIEDPKDNVFMVEKVLDKRTGKAGRDEFLIQWQGFPESDSSWEPRENLQCVEMLDEFEREFSKREKPIRKRHSQKPEPSEDQADPEEDKDEKKETNQNDKFSLEGKQLKCIVGLTKGPGELHFLCKFSDDTARLLPAKEVNSRYPSQVIRYYESKLTIQDPKADEL
Protein: Photosystem II repair protein PSB27-H1, chloroplastic (Psb27-H1) (Thylakoid lumenal protein PSB27-H1) (Q9LR64)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably involved in repair of photodamaged photosystem II (PSII).
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:16245054, ECO:0000269|PubMed:18431481}; Peripheral membrane protein {ECO:0000269|PubMed:16245054}; Lumenal side {ECO:0000269|PubMed:16245054}. Note=Associated with PSII on the lumenal side of the thylakoid membrane.
Interaction partners:
- Oxygen-evolving enhancer protein 1-1, chloroplastic
- Chlorophyll a-b binding protein CP26, chloroplastic
- Oxygen-evolving enhancer protein 3-1, chloroplastic
- Photosystem II CP43 reaction center protein
- Cytochrome b559 subunit alpha
- Oxygen-evolving enhancer protein 2-1, chloroplastic
- Oxygen-evolving enhancer protein 1-2, chloroplastic
- Photosystem II reaction center PSB28 protein, chloroplastic
- Photosystem II D2 protein
- Photosystem II CP47 reaction center protein
Sequence:
MASASATATLLKPNLPPHKPTIIASSVSPPLPPPRRNHLLRRDFLSLAATSTLLTQSIQFLAPAPVSAAEDEEYIKDTSAVISKVRSTLSMQKTDPNVADAVAELREASNSWVAKYRKEKALLGKASFRDIYSALNAVSGHYVSFGPTAPIPAKRKARILEEMETAEKALTRGR
Protein: Inward rectifier potassium channel 18 (Inward rectifier K(+) channel Kir2.6) (Potassium channel, inwardly rectifying subfamily J member 18) (B7U540)
Organism: Homo sapiens (Human)
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21209095, ECO:0000269|PubMed:21665951}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:21209095}.
Interaction partners:
- Potassium voltage-gated channel subfamily KQT member 1
- Potassium voltage-gated channel subfamily KQT member 2
- Inward rectifier potassium channel 2
- Potassium voltage-gated channel subfamily KQT member 3
- Potassium voltage-gated channel subfamily KQT member 4
- Potassium voltage-gated channel subfamily KQT member 5
- Voltage-dependent L-type calcium channel subunit alpha-1S
- ATP-sensitive inward rectifier potassium channel 14
- Guanine nucleotide-binding protein G
- Inward rectifier potassium channel 4
Sequence:
MTAASRANPYSIVSLEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIAFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLEPAEGHGRTPCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECLVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYRRGSEI
Protein: Damage-specific DNA binding protein 1 (F6VLN2)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSYNYVVTAQKPTAVNACVTGHFTSEDDLNLLIAKNTRLEIYVVTPEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQNGDSIDIITRAHGNVQDRIGRPSETGIIGIIDPDCRMIGLRLYDGLFKVIPLERDNKELKAFNIRLEELHVIDVKFLYSCQAPTICFVYQDPQGRHVKTYEVSLREKEFSKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDVNGSRYLLGDMEGRLFMLLLEKEEQMDGSVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLTAESNEQGSYVVVMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRVAADRDTDDTLVLSFVGQTRVLTLTGEEVEETDLAGFVDDQQTFFCGNVAHQQLIQITSASVRLVAQNPQSLVSEWKEPQGRKVSVCSCNSRQVLLAVGRVLYYLEIHPGELRQISCTEMEHEVACLDVTPLGGSDTLSSLCAIGLWTDISARILSLPGFQLLHKEMLGGEIIPRSILMTSFESSHYLLCALGDGALFYFSLNTDTGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSEGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDASGGSSPLRPSASTQALSSSVSCSKLFSGSTSPHETSFGEEVEVHNLLIIDQHTFEVLHTHQFLQNEYTLSLVSCKLGKDPTTYFVVGTAMVYPDEAEPKQGRIVVFQYNDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTAEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSPPTQGSVLFGTVNGMIGKISSIYGTHCFYLTTNKSSKSSLSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVIANLQIDDGSGMKRETTVDDLIKVVEELTRIH
Protein: Syntaxin, Qa-SNARE family (Q8ILE4)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Uncharacterized protein
- Alpha-soluble NSF attachment protein, putative
- SNARE protein, putative
- Vesicle-fusing ATPase
- Falcipain-3
- Cysteine proteinase falcipain 1
- Serine repeat antigen 3
- Syntaxin-binding protein, putative
- Protein transport protein SEC22
- Syntaxin, Qa-SNARE family
Sequence:
MEDILNEIISLSEKKRKEEQLKDMEEKNKKNKNDHIVDIKKIREEKSEYDFKIRKENKNTIKDIISNKKKKSSDSIKDDNTSIYCDASTICTIDDDINIEKANIFSKIIHDKKMNEDNYSNISNINNNNNNNNNNNNNYYYYYDDDILYFKDLENNIDENTPLKVNGFNNNLNSYLLHVNDINTHISSIYKNIDKINVIKKKIDLNIYDNEKLYNKVNVIITNSEDIVKYIKLKINELNNENNEFERNSNMVSEIKLRINIFIDVVNKYKSCINKYKNICNQYYEYVNKNIIKHYKLIHPNLKDHTIHKLLKQNNNNVEDFLNSNKNSFYENNIFCTNVEQIEIEKIKKKYNELKNLENNILSLNELYIELAYVIKKRKNLINNIENNVFQVKEYTQDALNNIVDAKKYNSMIKQRILYFSIFLLIVAFIILFPVFFNYTIF