wanglab/gogpt-training-data huggingface dataset:
Protein: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase family protein (Q729N0)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Flavin prenyltransferase UbiX
- 4-hydroxybenzoate polyprenyltransferase
- Chorismate dehydratase
- 1,4-dihydroxy-6-naphtoate synthase
- Cyclic dehypoxanthine futalosine synthase
- Aminodeoxyfutalosine synthase
- Futalosine hydrolase
Sequence:
MTYRNLSSCLIDLERNGHLIRIDTEVDARLELAAIQRRAFRAKAPAMLFTRVKGCRFPMVANLYGTRDRIRFIFRDTLRAVEGIFRLKIDPFDLFRHPQRYLGVPRSLWGMMPRTVRRGPVLECRTTVRELPQLVSWPMDGGGYVTLPQVYTESPDRPGFMHSNMGMYRVQLTGDHYEPDREVGLHYQIHRGIGYHHAEALRRGEPLRVNIFVGGPPAMTVAAVMPLPEGIAEVLFAGALGGFRIPMIRRAGGLPILAEADFCISGTIAPHQKPEGPFGDHLGYYSLAHDFPVLRVDAVHHRRDAVWPFTTVGRPPQEDTVFGEFIHELTAALVPQVFAGVHEVHAVDAAGVHPLLLAVGSERYVPYAGERQPQELITCGMALLGNTQTSLSKYVIIGAREDDHDLSAHDIPAFFTHMLERTDFSRDLHFITRTTIDTLDYTGISLNQGSKVVWAAAGSRRRDLADTLPETLTLPDGFGSPRLFHKGIVVLRGPRHTARRDEHDPAMERLAQSLDDVRGLSGVPLFVVVDDADFTAADWDNFLWVTFTRSDPATDLYGVGASTHCKHWGCRGPLIVDARLKSFHAPALETDPEVERRVDALAAPGGPLHGYL
Protein: VIP peptides [Cleaved into: Intestinal peptide PHI-27-like; Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)] (P48143)
Organism: Gallus gallus (Chicken)
Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
Subcellular location: Secreted.
Interaction partners:
- Vasoactive intestinal polypeptide receptor 2
- Calcitonin
- Uncharacterized protein
- Prolactin
- Uncharacterized protein.
- Tachykinin 1
- Progonadoliberin-1
- Somatostatin
- Gastrin/cholecystokinin-like peptide
- Guanine nucleotide-binding protein G
Sequence:
MEHRGASPLLLALALLSALCWRARALPPRGAAFPAVPRLGNRLPFDAASESDRAHGSLKSESDILQNTLPENEKFYFDLSRIIDRNARHADGIFTSVYSHLLAKLAVKRYLHSLIRKRVSSQDSPVKRHSDAVFTDNYSRFRKQMAVKKYLNSVLTGKRSQEELNPAKLRGEAEILEPSFSENYDDVSVDELLSHLPLDL
Protein: Mediator of RNA polymerase II transcription subunit 15 (Mediator complex subunit 15) (C9J1I1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU364148}.
Interaction partners:
Sequence:
MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQ
Protein: Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2) (Q52KR2)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Inactive heparanase-2
Sequence:
MAAAPRGIWEQRRLGCGLGPLARLLILAQALRLLPAARAGLCPAPCACRLPLLDCSRRKLPAPSWRALSGPLPSDISSLDLSHNRLSNWNNTLESQTLQEVKMNYNELTEIPYFGEPTPNITLLSLVHNLIPEINAEAFELYSALESLDLSSNIISEIKTSSFPRMSLKYLNLSNNRISTLEAGCFDNLSDSLLVVKLNRNRISMIPPKVFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTGVNKGWLYGLRMLQQLYMSQNAIEKISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNDISWAIEDASEAFSGLKSLTKLILQGNRIKSVTQKAFIGLESLEYLDLNNNAIMSIQENAFSQTHLKGLVLNTSSLLCDCHLKWLLQWLVDNNFHHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPESTIALRGVNVTLTCTAVSSSDSPMSTIWRKDSEILYDVDIENFVRYRQQDGEALEYTSVLRLFSVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPTPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNIAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCLMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYTHRGTDGGAGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLDQALSSLMVQMPKETFLSHPPQDAANLESLIPSAEREPAAFPTNHERMTENLPFSQRSSEIFQRPLWNMNRELGLLPFSQQPVLESPELTERDPNCSSPVTCRRLHDHAFDFSRTRIIQDGTEGT
Protein: Integrin beta (A8DSD5)
Organism: Sus scrofa (Pig)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}. Membrane raft {ECO:0000256|ARBA:ARBA00035630}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00035630}.
Interaction partners:
Sequence:
MLCRCSPLLLLVGLLTLRSALSQECAKYKVSTCRDCIESGPGCAWCQKLNFSGQGEPDSVRCDTREQLLAKGCVADDIVDPRSLAETQEDQAGGQKQLSPQKVTLYLRPGQAATFNVTFRRAKGYPIDLYYLMDLSYSMLDDLINVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKECQAPFAFRHVLKLTDNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKSSNEFDYPSVGQLAHKLAESNIQPIFAVTKKMVKTYEKLTDIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVSQVNQPRGDCDGVQINVPITFQVKVTASECIQEQSFVIRALGFTDTVTVRVLPQCECRCGDSSKERSLCGNKGSMECGVCRCDAGYIGKHCECQTQGRSSQELEGSCRKDNSSIICSGLGDCICGQCVCHTSDVPNKKIYGQFCECDNMNCERFDGQVCGGEKRGLCFCGTCRCQEGFEGSACQCLKSTQGCLNLQGVECSGRGRCRCNVCQCDFGYQPPLCTDCPSCQVPCARYAKCAECLKFDTGPFAKNCSAECGTTKLLPSRMSGRKCNERDSEGCWMTYFLVQRDGRDNYDLHVEETRECVKGPNIAAIVGGTVGGVVLVGIFLLAIWKVLTHLSDLREYKRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAER
Protein: Protein OPG146 (P68714)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Plays a role in the maturation of immature virions to infectious particles. May also participate in viral transcription.
Subcellular location: Virion {ECO:0000269|PubMed:23885081}. Host cytoplasm {ECO:0000269|PubMed:23885084}. Host nucleus {ECO:0000269|PubMed:23885084}.
Interaction partners:
Sequence:
MDSTNVRSGMKSRKKKPKTTVIDDDDDCMTCSACQSKLVKISDITKVSLDYINTMRGNTLACAACGSSLKLLNDFAS
Protein: DISCO interacting protein 1, isoform E (DISCO interacting protein 1, isoform G) (DISCO interacting protein 1, isoform I) (GH20159p) (RE10847p) (Q8MRC7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPLQAANVQEQQSSPVALYPTSASPVAVQSPQDAFLAVQSPGAPAPVQLANSSDQQNNPDADAIASKLPMPVIIKEEPISVNDEPSVDNIEDNTSASTSASGIGGKIPFKKIFQKRKKSSERTRDKKLRQNRQLRKSMLPKNALMALNEVKGVTISDFTIDSNTDGGFTAVVTVNSNQYEGKGTSKMTAKNAACEKAWRDFIIAKMTPKPPRIHQVEMGSEPMDINEDEADAPDDDLPMLNLASFAIYKLFAEWEREGYVVPEMHPSANAAQQAGGDAGTPVPPVPKEPKKPPVRTELPSGWETMHPATILCIMRPGLNYVDYGSSGDKTNGMQHLGIMVDNQEFHANGRSKKIARRNVAVKVCNSLFGTNFTYSDTT
Protein: Cytohesin 4a (Cytohesin-3) (F1RBL6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- ADP-ribosylation factor 6
- FERM domain-containing protein 4A
- ADP-ribosylation factor-like 4, like.
- ADP-ribosylation factor-like protein 4A
Sequence:
MKSPCSTATMGTQRKDSFLWGKAPSSFNANDKKQTEVHKHVILDDIKQLRMEIENMMTEIQTMEADDENKNVMKNKRIQCGKKKFNMDPKKGIQYLVDNGLLAWKPESVAEFLYKEEGLNKTAIGNFLGEREEIHLQILQAFVHLHEFSNLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCTCNTGVFQSTDTCYILSFAIIMLNTSLHNPNVKDKTTLERFISMNRGINNGGDLPSELLEKLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKEGGRIKTWKRRWFILTDGCLYYFQYTTDKEPKGIIPLENLCVKEVDDPHKQFCLEVYSLHQKGETIKACKTETDGRVVMGKHHSYKLSTASEEERAEWIQAIRACITKDPFYDLVSARKKKITNHNEPHD
Protein: Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) (Q86YW5)
Organism: Homo sapiens (Human)
Function: Cell surface receptor that may play a role in the innate and adaptive immune response.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15100151}; Single-pass type I membrane protein {ECO:0000269|PubMed:15100151}. Cytoplasm {ECO:0000269|PubMed:15100151}. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).
Interaction partners:
- Trem-like transcript 2 protein
- Triggering receptor expressed on myeloid cells 2
- Triggering receptor expressed on myeloid cells 1
- Platelet glycoprotein VI
- P-selectin
- Integrin alpha-IIb
- Platelet glycoprotein IX
- CKLF-like MARVEL transmembrane domain-containing protein 5
- TYRO protein tyrosine kinase-binding protein
- Acrosin-binding protein
Sequence:
MGLTLLLLLLLGLEGQGIVGSLPEVLQAPVGSSILVQCHYRLQDVKAQKVWCRFLPEGCQPLVSSAVDRRAPAGRRTFLTDLGGGLLQVEMVTLQEEDAGEYGCMVDGARGPQILHRVSLNILPPEEEEETHKIGSLAENAFSDPAGSANPLEPSQDEKSIPLIWGAVLLVGLLVAAVVLFAVMAKRKQGNRLGVCGRFLSSRVSGMNPSSVVHHVSDSGPAAELPLDVPHIRLDSPPSFDNTTYTSLPLDSPSGKPSLPAPSSLPPLPPKVLVCSKPVTYATVIFPGGNKGGGTSCGPAQNPPNNQTPSS
Protein: C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) (Kupffer cell receptor) (P10716)
Organism: Rattus norvegicus (Rat)
Function: Receptor with an affinity for galactose and fucose. Could be involved in endocytosis.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- Cd5 molecule-like.
- V-set and immunoglobulin domain containing 4
Sequence:
MKEAELNRDVAKFCTDNQCVILQPQGLGPKSAAPMAPRTLRHVQAIVALVVVTVFFSLLALFVVVLQPWRQKQNEDHPVKAGLHGGNYSGSDNCSQFVRRAEMQEAIQSLRASGNSSSCHKEIQTLKYQMDNVSSQVQLLGGHLEEANADIQQAKDVLKGTGALASETQALRSSLEVASADIHSLRGDLEKANAMTSQTQGLLKSSTDNTSAELHVLGRGLEEAQSEIQALRGSLQSSNDLGSRTQNFLQHSMDNISAEIQAMRDGMQRAGEEMTSLKKDLETLTAQIQNANGHLEQTDTQIQGLKAQLKSTSSLNSQIEVVNGKLKDSSRELQTLRRDLSDVSALKSNVQMLQSNLQKAKAEVQSLKTGLEATKTLAAKIQGQQSDLEALQKAVAAHTQGQKTQNQVLQLIMQDWKYFNGKFYYFSRDKKSWHEAENFCVSQGAHLASVTSQEEQAFLVQITNAVDHWIGLTDQGTEGNWRWVDGTPFDYVQSRRFWRKGQPDNWRHGNGEREDCVHLQRMWNDMACGTAYNWVCKKSTDWSVARTDQS
Protein: Na,K-ATPase alpha subunit isoform 1b/ii (Q5IRA0)
Organism: Salmo salar (Atlantic salmon)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
KNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGTCFDKSSATWASLARVAGLCNRAVFLAEQNNVPILKRDVAGDASESALLKCIELCCGSVKAMREKYSKIAEIPFNSTNKYQLSIHKNIAAGESKHLLVMKGAPERILDRCSTILIHGKEQPLDDELKEAFQNAYEELGGLGERVLGFCHFQLPDDQFAECFNFDCEEVNFPTENLCFVGLM
Protein: Neurexin-3-beta (A8DZ40)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MVFLEHLRGGTPRGTTTVSPILCLMNWNDEQCRQQLKSYIPKFASNFDAPRHVPQPPSSPSYDYEGDEDEEKKEEKDHGIADRSMNDVSGETTGRMCFGC
Protein: Abscisic acid receptor PYL11 (PYR1-like protein 11) (Regulatory components of ABA receptor 5) (Q9FJ50)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity). Suppresses the phosphatase activity of TOPP1 in a dose-dependent manner in vitro.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9FLB1}. Nucleus {ECO:0000250|UniProtKB:O49686}. Cell membrane {ECO:0000250|UniProtKB:O49686}. Note=Localizes at the plasma membrane in the presence of a CAR protein. {ECO:0000250|UniProtKB:O80920}.
Interaction partners:
- Protein phosphatase 2C 16
- Protein phosphatase 2C 37
- Protein phosphatase 2C 56
- Probable protein phosphatase 2C 75
- Protein phosphatase 2C 77
- Protein phosphatase 2C 3
- Probable protein phosphatase 2C 24
- Protein phosphatase 2C 7
- Probable protein phosphatase 2C 78
Sequence:
METSQKYHTCGSTLVQTIDAPLSLVWSILRRFDNPQAYKQFVKTCNLSSGDGGEGSVREVTVVSGLPAEFSRERLDELDDESHVMMISIIGGDHRLVNYRSKTMAFVAADTEEKTVVVESYVVDVPEGNSEEETTSFADTIVGFNLKSLAKLSERVAHLKL
Protein: E3 ubiquitin-protein ligase TRIM9 (B1GRL4)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MEEELKCTICIRFFEDPIILTCGHSLCRMCALKAHQPSTSSGSSSTSSPRPSTPGILSQILSSASSPISPQSAGSSSGASDTMSLCVSDNGDHESDKLSVVSETDSGVVGCGRTSRPSSIIGPPLSRLHNILTPSTSGVQLVCNSCQKPSYFCDENSIVSAPTNLAMQNVIRRYLLAHPDKAFLTPSCSGSSGSSGSSQSSDEASSQCQLCEGSENRMANVFCEQCDIYYCTPCQTALHPARGPLAKHNLLQANDGERKKSSAITTATTVRDLLRCATHPGEGLTMYCLACKVPVCSRCLQDLRHANHDVQSLPIACKGHKTELSTTLQQLSEKAKTATEEIGRLKGLHDVVKNNCNDFKSSLCIQIDQLIEQLQMRKEKLMQHVDEQADNKRRILKSQIVKCTGKLTKTSALIQFCIEALKEPDPTVYMQISNALLHRSTSLEFLWHKEMRTKPETDSEFVLNLDTKHLQYTIQTLDFAQLKVPSAPIIETSECSAENNSVTVVWRPRNDGSAVDGFALEIDTGRDDGNFKEVYSGPDTICTIDGLHFNTVYAARVKSYNSAGESEYSESICLQTAHVAWFQLTKSPSQRDMILSNECATLSGSSLEYRTILGSIAFSKGVHYWEVTIDRHDGNSDIVIGVAQPAVNRNVMLGKDLHGWSMYVDGERSWYLHNETHHNRVLGGVTRGTVIGVRLDCDRGTMEYTVNDRKRIYQDDSMAFTNMPRGLYYPAFSVNANSSITVHTGLSSPSS
Protein: SD19268p (A1Z934)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- hydroxymethylglutaryl-CoA lyase
- Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
- Hydroxymethylglutaryl-CoA synthase
- GM14617p
- Isovaleryl-CoA dehydrogenase, mitochondrial
- Acetyl-CoA acetyltransferase 1, isoform A)
- Signal peptidase complex subunit 3
- HL08109p)
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Sequence:
MSMLIKRASGLARQLARPLVASRNLASAAPYGDGTEVLVERLDGARQGISVIGLNRPAAKNSFSRGMVETFNDVLEDIKKDNGSRVVVLRSLSPGIFCAGADLKERKGMTPEEATEFVKELRGLLIAIEQLPMPVIAAVDGAALGGGLEMALACDIRTAASDTKMGLVETRLAIIPGAGGTQRLPRILSPALAKELIFTARVFNGAEAKDLGLVNHVVKQNETQDAAYQQALKLAEEILPNGPVGVRMAKLAIDKGMQVDLATGYSIEEICYSQVIPTKDRLEGLAAFAEKRKPVYKGE
Protein: E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3) (Q08D68)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9ULT6}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Uncharacterized protein.
- R-spondin-2
- Uncharacterized protein.
- Leucine-rich repeat-containing G-protein coupled receptor 5
- Leucine-rich repeat-containing G-protein coupled receptor 4
- Uncharacterized protein
- Frizzled class receptor 4
- Frizzled class receptor 8
- Frizzled-7
- FZ domain-containing protein.
Sequence:
MKEPRIRGGLPLVWLWVLLAVAPGESLAKETAFVEVVLFESSPNGDYKTHTTELQGRFSRAGATISAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPEMDPKPCLTVLGKAKRAVQRGATAVIFDVSDNPDAVEQLNQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLIKIKLKQRRSQNSMNRMAVQALEKMETRKFKAKGKVPREGSCGGLDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHKRCVDPWLLQNHTCPHCRHNIIEQKKGGHGPVCVENSSNRGRQQQQQRVILPVHYPGRVQRTGPIAAYPTRTSMGPHGNPITVLTVERPLEPDLYPARTPTFLAGYRPVSLDHASSGHHCDLEHPPYPAPPAGHGFRRAKYSGRGFNNGTCYSQYETMYQHYYFQGLSYPHQQEVGGSQAPRVVENGHNHSFHSGNNMLYQPAPTLMHMAPPSSVGSCYLHSQHQHRSVCSGYLADVPCSDSSSSSSASSAQGHASSSDSMLDCTEASNQGVYGSCSTFRSSLSSDFDPYVYRSRSPARTGGGDAPGCGGEGGTGSGRGRVECRSHQTFPNSPSRDRLSSCSMEMNYSSNSSLERRGAVISSGTVPDASVSISQGGGKDRRGPEKGCTCCFQRQAGDPSSDCTNLYLGPDPHQTSGPSSSGGLYSVTSSILHRTDPGTVLGHPSRPCCLYEENHGSCYNEDYAVSIQYALAEAAAAAAAAAVAGCEAGQPIPIIPEDPGYDGGLECVGHVSWEMEGEEEEEEVLYCQEGPCCALAEETRALCRSTGKEGAGSTTGQDCHPTDRD
Protein: Beta-glucosidase 46 (AtBGLU46) (EC 3.2.1.21) (O80690)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolyzes p-nitrophenyl beta-D-glucoside, p-nitrophenyl beta-D-galactoside and natural glucosides such as salicin, p-coumaryl alcohol glucoside, phenyl-beta-D-glucoside, coniferin, syringin and arbutin. May be involved in lignification by hydrolyzing monolignol glucosides.
Interaction partners:
- Beta-glucosidase 45
- Beta-glucosidase 22
- Beta-glucosidase 21
- Beta-glucosidase 23
- UDP-glycosyltransferase 72E3
- Beta-glucosidase 30
- Beta-glucosidase 7
- Beta-glucosidase 33
- Beta-glucosidase 20
- Beta-glucosidase 15
Sequence:
MKTFANFAILFLLQSLLFPLYSSCLHQTSDDSSPFPSDFLFGTASSAFQYEGAFLTDGKGLNNWDVFAHENPGKIVDGSNGDIATDQYHRYMEDIQSMNFLGVNSYRLSISWSRVLPNGRFGVINYKGIKYYNNLIDALIKKGITPFVTLNHFDYPQELENRFKSWLSSEMQKDFGYLADICFKHFGDRVKHWITINEPNQHISLAYRSGLFPPARCSMPYGNCTHGNSETEPFIAAHNMILAHAKAIQIYRTKYQREQKGIIGIVVQTSWFEPISDSIADKNAAERAQSFYSNWILDPVVYGKYPEEMVNLLGSALPKFSSNEMNSLMSYKSDFLGINHYTSYFIQDCLITACNSGDGASKSEGLALKLDRKGNVSIGELTDVNWQHIDPNGFRKMLNYLKNRYHNIPMYITENGFGQLQKPETTVEELLHDTKRIQYLSGYLDALKAAMRDGANVKGYFAWSLLDNFEWLYGYKVRFGLFHVDFTTLKRTPKQSATWYKNFIEQNVNIEDQIDK
Protein: Cold-regulated 413 plasma membrane protein 4 (AtCOR413-PM4) (O23164)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Dormancy-associated protein 1
Sequence:
MGRGEFLAMKTEENAANLINSDMNEFVAAAKKLVKDVGMLGGVGFGTSVLQWAASIFAIYLLILDRTNWKTKMLTTLLVPYIFFTLPSVIFQFFSGDFGKWIALIAIIVRLFFPKEFPEWLEIPVALILIVVVSPSLIAWTLRESWVGAVICLVIACYLFHEHIKASGGFKNSFTQKNGISNTIGIVALLVYPVWTIFFHIF
Protein: Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase) (P0A7D4)
Organism: Escherichia coli (strain K12)
Function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Subcellular location: Cytoplasm.
Interaction partners:
- Adenylosuccinate lyase
- Bifunctional purine biosynthesis protein PurH
- Inosine-5'-monophosphate dehydrogenase
- GMP reductase
- GMP synthase
- Phosphoribosylformylglycinamidine synthase
- Hypoxanthine phosphoribosyltransferase
- Adenylate kinase
- Aspartate carbamoyltransferase catalytic subunit
- Phosphoribosylamine--glycine ligase
Sequence:
MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGATTGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPLAADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRTETMILRDPFDA
Protein: Down syndrome cell adhesion molecule 1, isoform AN (Q0E9K8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVNQFYEAEIMTEYVIRGNAAVLKCSIPSFVADFVRVESWIDDEGNVLSFSDNYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVAPRVNKKDGFSHDSIRQDRTIAIFCPAQAYPVPFYRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVPPQVVPFDFGEETINMNDMVSATCTVNKGDTPLELYWTTAPDPTTGVGRLMSNDGILITKTTQRISMLSIESVHARHRANYTCVARNAAGVIYHTAELRVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQQANGAGFTAYDTMAV
Protein: Envelope small membrane protein (E) (sM protein) (P0DTC4)
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Function: Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Regulates the localization of S protein at cis-Golgi, the place of virus budding. May act by slowing down the cell secretory pathway. May interfere with tight-junction stability by interacting with host MPP5. This would result in disruption of epithelial barriers, thereby amplifying inflammatory processes.
Subcellular location: Host Golgi apparatus membrane {ECO:0000255|HAMAP-Rule:MF_04204}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04204, ECO:0000269|PubMed:32898469, ECO:0000269|PubMed:33177698}. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04204}.
Interaction partners:
Sequence:
MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV
Protein: Hydrolase, alpha/beta fold family, putative (Q582C7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Acyl carrier protein
Sequence:
MLTTTDTIVKVGKCASTGEDISLSYDTFGNSKDPCLLLVVGLAGVGRVWRDAFCEMIAKKGFYVVRYDNRDVGLSTHLDNQPTPNVMQCLLPQFLSFLRKVPYTLEDMAADGMNLLTALGIERAHVVGSSMGGMIAQIMAIKYPSRVRSLGIIYSHTGSSKRVPETFSTKLLFMKKPKSSALEDVVDFKCALARHFRGPGYNVDEEEFRKLAKEQLERANDYPQGMLRQLAAILSAKSREECLKTITIPTLIIHGMLDEVVPYQNGLQIAEAVGPAAKLVIYPRMGHEIPVELMPSISQEIADNCGRELTLA
Protein: Homeotic protein female sterile (Fragile-chorion membrane protein) (P13709)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required maternally for proper expression of other homeotic genes involved in pattern formation, such as Ubx.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Centrosome-associated zinc finger protein Cp190
- Transcription initiation factor TFIID subunit 7
- Boundary element associated factor
- Modifier of mdg4
- FI11703p
Sequence:
MSSSEPPPRYEPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQKIESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVSVAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKKGVKRKADTTTPTANAFESPYTQMDSKSAKIATRRESNRQDLTFQGSGYNMSPLGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYANIPDEPVANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLKHDASDSSSEDSSDTENESNSDEERSARLKMLESKLLGLQEEIRKLSEEASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSGAGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRKKTHKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAKKDESASSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSDSSDSEAGDGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNTPTSQMSNMLGNANPLTAAAMLNNNNKTSLPGSNFGGAPAPGNMMHAGAGVPVAGAAVSASTGQQHNKNGPNDLSKVQPGGPINAALPPHSFAGGTATVATSQSSGGIRIASNLHKPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLGGSHGDAMVNASLASLASGLKQIPQFDDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLMQPAGPQQQQQQQQQQPFGHQQQQQQQQQQQQQQQQHMDYVTELLSKGAENVGGMNGNHLLNFNLDMAAAYQQKHPQQQQQQAHNNGFNVADFGMAGFDGLNMTAASFLDLEPSLQQQQMQQMQLQQQHHQQQQQQTHQQQQQHQQQHHQQQQQQQLTQQQLQQQQQQQQQQQHLQQQQHQQQHHQAANKLLIIPKPIESMMPSPPDKQQLQQHQKVLPPQQSPSDMKLHPNAAAAAAVASAQAKLVQTFKANEQNLKNASSWSSLASANSPQSHTSSSSSSSKAKPAMDSFQQFRNKAKERDRLKLLEAAEKEKKNQKEAAEKEQQRKHHKSSSSSLTSAAVAQAAAIAAATAAAAVTLGAAAAAALASSASNPSGGSSSGGAGSTSQQAITGDRDRDRDRERERERSGSGGGQSGNGNNSSNSANSNGPGSAGSGGSGGGGGSGPASAGGPNSGGGGTANSNSGGGGGGGGPALLNAGSNSNSGVGSGGAASSNSNSSVGGIVGSGGPGSNSQGSSGGGGGGPASGGGMGSGAIDYGQQVAVLTQVAANAQAQHVAAAVAAQAILAASPLGAMESGRKSVHDAQPQISRVEDIKASPGGQGQSSPAQQSPQDRAAAKRAEQRRAEQERRRREALAGQIDMNMQSDLMAAFEETL