wanglab/gogpt-training-data huggingface dataset:
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) (Q4KWH8)
Organism: Homo sapiens (Human)
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15702972, ECO:0000269|PubMed:33820834}. Membrane {ECO:0000269|PubMed:15702972}.
Interaction partners:
- Inositol polyphosphate multikinase
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Multiple inositol polyphosphate phosphatase 1
- Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
- Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
Sequence:
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL
Protein: Protein S-acyltransferase 21 (EC 2.3.1.225) (Probable palmitoyltransferase At2g33640) (Zinc finger DHHC domain-containing protein At2g33640) (Q6DR03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: S-acyltransferase involved in protein lipid modification.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- GLABROUS1 enhancer-binding protein-like 3
- Probable protein S-acyltransferase 9
- Protein BASIC PENTACYSTEINE7
- Zinc-finger homeodomain protein 3
- AP-3 complex subunit delta
- AP3-complex subunit beta-A
- CDT1-like protein a, chloroplastic
Sequence:
MARRHGWQLPAHTFQVVAITVFFLLTVAYYAFFAPFLGNKLYEYIAIGVYSFLAFSVLVLYIRCTGIDPADPGIFVKADNTPAHKSQNSNYVPENASAIDGGPYIRHGSGCCSAIGRFICGCLVIQDCRRDTQQEQSNEQEEALFCSLCNAEVRMFSKHCRSCGKCVDGFDHHCRWLNNCVGQKNYISFVCLMAASFFWLIAEFGVGVTVFVRCFVDQKAMEHLITEKLGLGFSRPPFAAVVVVCTTLSLLALIPLGELFFFHMILIRKGITTYEYVVALRAQTEPLGTSVDELDQTSQYPSPASSAVTATSARSSLGLSIQYRGASLCTPPNIFVDQQDDVIQHLEPGPVRSTIDPDSLSQKKPPQRQQVRINPWKLAKLDSKEASKAAAKARASSSVLLPVSSRQNPYKTSSNVSGRSSPGRGKPADSESCSLSSPGLTRDHFNPMYMSSPANESPLNEEESRNAVVAARRNLPSSDESSVVWDPEAGRFVSLSRIPGTDVGGPLGNECLNTITSTGTDRSRRARGNPLTGYFQQVRSQRGDQLPVFMPTDSQLHRHLSTRFH
Protein: Probable transcriptional activator protein TraR (P55407)
Organism: Sinorhizobium fredii (strain NBRC 101917 / NGR234)
Function: Positive regulation of conjugal transfer. TraR activates target genes in the presence of AAI and also activates traR and traI themselves (By similarity).
Interaction partners:
Sequence:
MSVNGNLRSLIDMLEAAQDGHMIKIALRSFAHSCGYDRFAYLQKDGTQVRTFHSYPGPWESIYLGSDYFNIDPVLAEAKRRRDVFFWTADAWPARGSSPLRRFRDEAISHGIRCGVTIPVEGSYGSAMMLTFASPERKVDISGVLDPKKAVQLLMMVHYQLKIIAAKTVLNPKQMLSPREMLCLVWASKGKTASVTANLTGINARTVQHYLDKARAKLDAESVPQLVAIAKDRGLV
Protein: Ankyrin repeat domain-containing protein 13C (Q8N6S4)
Organism: Homo sapiens (Human)
Function: Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20959461}. Note=Associated with the cytosolic side.
Interaction partners:
Sequence:
MTGEKIRSLRRDHKPSKEEGDLLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHRLQLKAAPASSNPPGAPALPLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHWDFQSWVPLLSRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESFVVLDNEQKVYQRIHHEESEMETEEEVDILMSSDIYSATLSTKSISFTRAQTGWLFREDKTERVGNFLADFYLVNGLVLESRKRREHLSEEDILRNKAIMESLSKGGNIMEQNFEPIRRQSLTPPPQNTITWEEYISAENGKAPHLGRELVCKESKKTFKATIAMSQEFPLGIELLLNVLEVVAPFKHFNKLREFVQMKLPPGFPVKLDIPVFPTITATVTFQEFRYDEFDGSIFTIPDDYKEDPSRFPDL
Protein: Zinc finger protein 302 (Zinc finger protein 135-like) (Zinc finger protein 140-like) (Zinc finger protein 327) (Q9NR11)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MSQVTFSDVAIDFSHEEWACLDSAQRDLYKDVMVQNYENLVSVGLSVTKPYVIMLLEDGKEPWMMEKKLSKAYPFPLSHSVPASVNFGFSALFEHCSEVTEIFELSELCVFWVLHFLSNSPNSTVEAFSRSKKKKKKKKKRQCFAFLIYFRLGIKMGKQGIINKEGYLYEDSPQPVTMEKVVKQSYEFSNSNKNLEYTECDTFRSTFHSKSTLSEPQNNSAEGNSHKYDILKKNLSKKSVIKSERINGGKKLLNSNKSGAAFNQSKSLTLPQTCNREKIYTCSECGKAFGKQSILSRHWRIHTGEKPYECRECGKTFSHGSSLTRHQISHSGEKPYKCIECGKAFSHGSSLTNHQSTHTGEKPYECMNCGKSFSRVSLLIQHLRIHTQEKRYECRICGKAFIHSSSLIHHQKSHTGEKPYECRECGKAFCCSSHLTQHQRIHSMKKKYECNKCLKVFSSFSFLVQHQSIHTEEKPFEV
Protein: Solute carrier family 25 member 47 (Hepatocellular carcinoma down-regulated mitochondrial carrier homolog) (Mitochondrial NAD(+) transporter SLC25A47) (Q6IS41)
Organism: Mus musculus (Mouse)
Function: Uncoupling protein which may catalyze the physiological 'proton leak' in liver.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:36804859}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:36804859}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ubiquitin-like protein FUBI
Sequence:
MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEAKYAGIWHCIRDTYRQERVWGFYRGLSLPVCTVSLVSSVSFGTYHHCLAHICRFRYGSTDAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQTQQRRSSASWTSGAPALCPTPTACLEPRPKYSGPLHCLVTVAREEGLRGLYKGSSALLLREGHSFATYFLSYAMLCEWLTPAGHSQPDVLGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQGQHRYRGLLHCVVTSVREEGPRVLFKGLALNCCRAFPVNMVVFVAYEAVLRLTQSLLT
Protein: ER membrane protein complex subunit-like protein (DUF2012) (Q84JM6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 1
- Membrane magnesium transporter
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 10
- ER membrane protein complex subunit 8/9 homolog
- Uncharacterized protein family
Sequence:
MTMTSIIRSSPTLAFIVLQICFIFFASTFPCSSGSEDSYTITGRVKIPPSNVIGHIAKFSNVKVILNGGQKITFLRPDGYFTFHEVPAGTHLIEVSAMGYFFSPVRVDVSARHRGKVQATLTETRRSLTELVLEPLKEEQYYEIREPFNIMSIVKSPMGLMVGFMVVVVFLMPKLMENIDPEEMKQAQEEMRRQGVPSLTSLLPGAGASR
Protein: Exonuclease 1 (EC 3.1.-.-) (Q5T397)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU910737}.
Interaction partners:
Sequence:
MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDRRRQANLLKGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLGMCRQLGDV
Protein: Putative general secretion pathway protein A (P45756)
Organism: Escherichia coli (strain K12)
Function: May play a regulatory role under conditions of derepressed gsp gene expression.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Putative general secretion pathway protein B
- Putative type II secretion system protein C
- Prepilin leader peptidase/N-methyltransferase
- Putative type II secretion system protein L
- Uncharacterized protein YacC
- Bifunctional glutathionylspermidine synthetase/amidase
- Putative type II secretion system protein E
- Putative type II secretion system protein F
- Putative type II secretion system protein M
- Type II secretion system core protein G
Sequence:
MSTRREVILSWLCEKRQTWRLCYLLGEAGSGKTWLAQQLQKDKHRRVITLSLVVSWQGKAAWIVTDDNAAEQGCRDSAWTRDEMAGQLLHALHRTDSRCPLIIIENAHLNHRRILDDLQRAISLIPDGQFLLIGRPDRKVERDFKKQGIELVSIGRLTEHELKASILEGQNIDQPDLLLTARVLKRIALLCRGDRRKLALAGETIRLLQQAEQTSVFTAKQWRMIYRILGDNRPRKMQLAVVMSGTIIALTCGWLLLSSFTATLPVPAWLIPVTPVVKQDMTKDIAHVVMRDSEALSVLYGVWGYEVPADSAWCDQAVRAGLACKSGNASLQTLVDQNLPWIASLKVGDKKLPVVVVRVGEASVDVLVGQQTWTLTHKWFESVWTGDYLLLWKMSPEGESTITRDSSEEEILWLETMLNRALHISTEPSAEWRPLLVEKIKQFQKSHHLKTDGVVGFSTLVHLWQVAGESAYLYRDEANISPETTVKGK
Protein: Periostin isoform R1 (Periostin, osteoblast specific factor (Predicted), isoform CRA_c) (A0A097BW25)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MVPLLPLSALLLLFLCDVDPANANSYYDKVLAHSRIRGRDQGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWDNLDSDIRRGLENNVNVELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLTQIGTSIQDFIEAEDELSSFRAAAITSDLLESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHEKLRQDKRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTNEEREILIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYVKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYRPAMTKIHIEGEPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVPVEITEKETREERIITGPEIKYTRISTGGGETEETLQKFLQKDTPAKKIQANKRVQGSRRRSREGRSQ
Protein: NADP-dependent alcohol dehydrogenase 7 (EC 1.1.1.2) (NADP-dependent alcohol dehydrogenase VII) (ADHVII) (P25377)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: NADP-dependent alcohol dehydrogenase with a broad substrate specificity. The oxidative reactions are more than 100 times less efficient than the corresponding reductions, suggesting that the enzyme acts as an aldehyde reductase, rather than as an alcohol dehydrogenase.
Interaction partners:
- NADP-dependent alcohol dehydrogenase 6
- Magnesium-activated aldehyde dehydrogenase, cytosolic
- Potassium-activated aldehyde dehydrogenase, mitochondrial
- Aldehyde dehydrogenase [NAD
- Thiamine metabolism regulatory protein THI3
- Pyruvate decarboxylase isozyme 2
- Pyruvate decarboxylase isozyme 1
- Pyruvate decarboxylase isozyme 3
- Aldehyde dehydrogenase [NAD
- Aldehyde dehydrogenase 5, mitochondrial
Sequence:
MLYPEKFQGIGISNAKDWKHPKLVSFDPKPFGDHDVDVEIEACGICGSDFHIAVGNWGPVPENQILGHEIIGRVVKVGSKCHTGVKIGDRVGVGAQALACFECERCKSDNEQYCTNDHVLTMWTPYKDGYISQGGFASHVRLHEHFAIQIPENIPSPLAAPLLCGGITVFSPLLRNGCGPGKRVGIVGIGGIGHMGILLAKAMGAEVYAFSRGHSKREDSMKLGADHYIAMLEDKGWTEQYSNALDLLVVCSSSLSKVNFDSIVKIMKIGGSIVSIAAPEVNEKLVLKPLGLMGVSISSSAIGSRKEIEQLLKLVSEKNVKIWVEKLPISEEGVSHAFTRMESGDVKYRFTLVDYDKKFHK
Protein: Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Q567N5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Large ribosomal subunit protein uL30
- Small ribosomal subunit protein RACK1
- Ubiquitin-ribosomal protein eS31 fusion protein
- Large ribosomal subunit protein eL27
- Ribosomal protein L3
- Ribosomal protein L4
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL33
- Ribosomal protein L18
- Small ribosomal subunit protein uS15
Sequence:
MAEGDKKKVARKHGSRNPELVRGIGRYSRSAMFARRAMYKRKTKAPVTKVEKKIKEKKVKQKSKNPTTAIKTVGGDKNGGTRVVKLRKMPRYYPTEDVRRKLRSHGIKAFSQHRRKLRKTITPGTVLIMLTGRHRGKRVVFLKQLDSGLLLVTGPLAINRVPLRRAHQKFCIATNTKVDISGMKIPRTLTDSYFKKKKLRKPKHQEGEIFDTEKEKYQLTEQRKADQKAVDSQLLPLIKKVPQLRGYLRSMFSLSNGVYPHKLVF
Protein: Sushi-repeat-containing protein, X-linked (A0A8I6AAL5)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
LGSQGLIAPLAWTMPTQCFEMCAHTVWLFLLQSLFFVFLVGSGDSPLEDDGVWSSHSLYKDTPWCSPIKVKYGDVYCRAPPGGYYKTALGTRCDIRCRKGYELHGSSQLVCQSNRRWSDKVICKQKRCPTLTMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILRGLPPGSNFPEGDHKIEYTVYDRAENKGTCKFRVKVRVRRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSCAGSFRCLDEERCQVPQAQCGLDLRHITVVELVGVFPTLIGRIRAKIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVSLVTPMALFNLIDTFPLRKEEMILQAEMGQSCNT
Protein: Chemokine CK-1 (Q9PT03)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MISCRVCVLAALSSLLIITLIPTTQSADCCLKLTRRPVHCRWLKGYTFQDITSSCDLNAVIFQNLRNKFVCADPSQDWTKRVQRCLRKRQEKKSQLKKRV
Protein: Proteasome subunit alpha type (Q5B0Q8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Interaction partners:
- Proteasome subunit alpha type
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit RPN1
- MPN domain-containing protein
- 26S proteasome regulatory subunit 6A
- 26S proteosomal regulatory subunit
- 26S proteasome regulatory subunit S5A
- Proteasome subunit alpha type
- Proteasome subunit beta
- proteasome endopeptidase complex
Sequence:
MFIARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATSEGVILGVEKRVTSTLLEASSVEKIVEIDQHIGCAMSGLQADARSLVEHARVETQNHAFHYAEPLRVESCTQAICDLALRFGETGDDEESVMSRPFGVALLIAGIDEDGPQLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHRSLTLAEAETLVLKTLKQVMEEKLDAKNVQLASVTKEKGFRIYNDEEMGRAVAQLGGNQ
Protein: Phosrestin-2 (Arrestin-1) (Arrestin-A) (Phosrestin II) (P15372)
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulates photoreceptor cell deactivation. Arr1 and Arr2 proteins are mediators of rhodopsin inactivation and are essential for the termination of the phototransduction cascade.
Subcellular location: Cell projection, rhabdomere {ECO:0000269|PubMed:8316831}.
Interaction partners:
- Opsin Rh1
- Phosrestin-1
- Clathrin heavy chain
- Transient-receptor-potential-like protein
- Opsin Rh3
- Opsin Rh6
- Opsin Rh5
- Protein kinase C, eye isozyme
- Transient receptor potential protein
- Neither inactivation nor afterpotential protein C
Sequence:
MVVNFKVFKKCSPNNMITLYMNRRDFVDSVTQVEPIDGIIVLDDEYVRQNRKIFVQLVCNFRYGREDDEMIGLRFQKELTLVSQQVCPPQKQDIQLTKMQERLLKKLGSNAYPFVMQMPPSSPASVVLQQKASDESQPCGVQYFVKIFTGDSDCDRSHRRSTINLGIRKVQYAPTKQGIQPCTVVRKDFLLSPGELELEVTLDKQLYHHGEKISVNICVRNNSNKVVKKIKAMVQQGVDVVLFQNGQFRNTIAFMETSEGCPLNPGSSLQKVMYLVPTLVANCDRAGIAVEGDIKRKDTALASTTLIASQDARDAFGIIVSYAVKVKLFLGALGGELCAELPFILMHPKPSRKAQLEAEGSIEA
Protein: Putative aquaporin-12B (AQP-12B) (A6NM10)
Organism: Homo sapiens (Human)
Function: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQAACTLTRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSGVEGPHSS
Protein: snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE-binding factor subunit delta) (PTF subunit delta) (Small nuclear RNA-activating complex polypeptide 2) (snRNA-activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Q13487)
Organism: Homo sapiens (Human)
Function: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subcellular location: Nucleus.
Interaction partners:
- snRNA-activating protein complex subunit 4
- snRNA-activating protein complex subunit 1
- snRNA-activating protein complex subunit 3
- snRNA-activating protein complex subunit 5
- TATA-box-binding protein
- Transcription factor IIIB 50 kDa subunit
Sequence:
MKPPPRRRAAPARYLGEVTGPATWSAREKRQLVRLLQARQGQPEPDATELARELRGRSEAEIRVFLQQLKGRVAREAIQKVHPGGLQGPRRREAQPPAPIEVWTDLAEKITGPLEEALAVAFSQVLTIAATEPVTLLHSKPPKPTQARGKPLLLSAPGGQEDPAPEIPSSAPAAPSSAPRTPDPAPEKPSESSAGPSTEEDFAVDFEKIYKYLSSVSRSGRSPELSAAESAVVLDLLMSLPEELPLLPCTALVEHMTETYLRLTAPQPIPAGGSLGPAAEGDGAGSKAPEETPPATEKAEHSELKSPWQAAGICPLNPFLVPLELLGRAATPAR
Protein: Non-structural maintenance of chromosomes element 4 homolog A (Non-SMC element 4 homolog A) (Q9C689)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Structural maintenance of chromosomes protein 6B
- Structural maintenance of chromosomes protein 6A
- Non-structural maintenance of chromosomes element 1 homolog
- Structural maintenance of chromosomes protein 5
- E3 SUMO-protein ligase MMS21
- Structural maintenance of chromosomes protein 3
- Structural maintenance of chromosomes protein 1
- Protein GRAVITROPIC IN THE LIGHT 1
- Negative regulator of systemic acquired resistance SNI1
- Structural maintenance of chromosomes protein 4
Sequence:
MRKTVKRESEATGGKREADDEPEKLRSVKKEKQRKTEADSVRPDEPPPPQEEEQGISDRRILRSKYLSLQNEINDCKDDLMKIDSDKFSRIINAVENLHQQVRKPREQIADAEALLDIANTLMSSVKSQSAHGVSPAEFVNALISGFGQGSLGIDTDETAQVSLKWKDLGFAVCSTVLVSCGCSTMLGPMDTELKQRKRAPNRKRTKPGEGVRPDEVDDSQSEEKTDTDKNMTIMFNILGKKKRVQLENLVLNRRSFAQTVENLFALSFLAKDGRVEIIVDKSGSHFAMPRNAPDANVVMSGEVIYNHFVFRLDFKDWKLMSEMVPLGEELMPHRQTAVASSSCPAASAPASADFTQDTQTTPIRKLSRNRGLVVQEETVVEDTPDKEGDGTRRRCKRRLTSS
Protein: Urease (EC 3.5.1.5) (Urea amidohydrolase) (E0ZS48)
Organism: Oryza sativa subsp. indica (Rice)
Function: Urea hydrolase involved in nitrogen recycling from ureide, purine, and arginine catabolism.
Interaction partners:
Sequence:
MKLVQREAEKLALHNAGFLAQKRLARGLRLNYTEAVALIAAQILEFVRDGDRTVTDLMDLGKQLLGRRQVLPAVPHLLETVQVEGTFMDGTKLITVHDPISSDDGNLELALHGSFLPVPSLEKFSSVGVDDFPGEVRFCSGHIVLNLHRRALTLKVVNKADRPIQIGSHYHFIEANPYLVFDRQRAYGMRLNIPAGTAVRFEPGDAKTVTLVSIGGRKVIRGGNGIADGAVNRSQLNEVMEKVIAKGFGHEDYPDSSEGIIGDGTHDYIVDHEKYASMYGPTTGDKIRLGDTDLFAEIEKDYAIYGDECIFGGGKVLRDGMGQSAGYPASDCLDTVVTNAVVIDYTGIYKADIGINGGLIVAIGKAGNPDVMDMDGVNEEMIVGVNTEVIAAEGMIVTAGGIDCHVHFICPQLAEEAIASGITTLVGGGTGPAHGTCATTCTPSPSHMKLMLQSTDELPINMGFTGKGNTTKPDGLAEIIKAGAMGLKLHEDWGSTPAAIDNCLSVAEAFDIQVNIHTDTLNESGCVEHTIAAFKDRTIHTYHSEGAGGGHAPDIIKVCGVKNVLPSSTNPTRPFTLNTVDEHLDMLMVCHHLDRNIPEDVAFAESRIRAETIAAEDILHDMGAISIISSDSQAMGRIGEVITRTWQTANKMKRQRGRLPISSSPDAAEDNDNFRIRRYIAKYTINPAIVNGFSDFVGSVEVGKLADLVIWKPSFFGAKPEMVIKGGAIACANMGDPNASIPTPEPVMMRPMFGAFGGAGSANSIAFVSKAAKEAGVAVQYKLGKRVEAVGRVRGLTKLNMKLNDALPKIDVDPETYTVTADGEVLRCQPTPTVPLSRNYFLF
Protein: Austinoid biosynthesis clusters protein J (C8VQ92)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA. 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN. Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A. Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE. Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4. The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide. Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol. Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation. Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional.
Interaction partners:
- FAD-dependent monooxygenase ausM
- Cytochrome P450 monooxygenase ausI
- Aldo-keto reductase ausK
- Cytochrome P450 monooxygenase ausG
Sequence:
MNTTRHRLLATASRFVETLESLDVDAMLAIRSSTCLHHMCCPSFRNYSITNDQTREAFPQWKATITKYKFGVLDDSQILVDEQARKVMIHAETAAETTVGDYNNEYVFILRMAEDCNTVDEIWEFYDTIRLQDLRHRLEASHVPIGVDAPAPFTTTASPAAL
Protein: Novopsin-3 (Opsin 7, group member a) (F1RAF0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Parietopsin
- CLOCK-interacting pacemaker b.
Sequence:
MQGLDNSTFQSNIPVAADITVGIVYSLFGVCSLCGNSMLLYVSYKKKHLLKPAEFFIVNLAISDLGMTLSLYPLAVTSSIAHRWLYGRTVCVIYAFCGVLFGICSLTTLTILSTVCCLKVCYPLHGNRFSYEHGRMLIVCAWAYSLVFACSPLAHWGQYGPEPYGTACCIDWAWSNQNSVARSYTTVLFIACYLVPCVIIIISYTRILITVRESRRAVEQHVSAQTRMGNIQTIIVKLSVAVCIGFFTAWSPYALVSMWAAFGHFDDIPPMAFAVPAMFAKSSTLYNPLIYLLLKPNFRHLLCKDMRSLRGVCMHHCLCQCFPPWSYRPSLALSLRPLRRRGQSISESMGGPVGQCHCPCERCNDPFEQFKHYPRRCPVKVNTVQLSLQDSTEPELEPEPEPKMLKEGKPKSQSVECKKSVRVIVRGRKCSEIDSLEITLETVPAPGTAAKNTKP