wanglab/gogpt-training-data huggingface dataset:
Protein: B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) (O95999)
Organism: Homo sapiens (Human)
Function: Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex. This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity. Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17287217}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:17287217}.
Interaction partners:
- Caspase recruitment domain-containing protein 10
- NF-kappa-B essential modulator
- Caspase recruitment domain-containing protein 11
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1
- TNF receptor-associated factor 6
- Caspase recruitment domain-containing protein 9
- Caspase-8
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Caspase recruitment domain-containing protein 14
Sequence:
MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGESSTTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANSSEMFLPLRSRTVSRQ
Protein: tRNA modification GTPase MnmE (EC 3.6.-.-) (Q8KAS1)
Organism: Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Function: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00379}.
Interaction partners:
- tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
- Ribosomal RNA small subunit methyltransferase G
- Pseudouridine synthase
- Chaperone protein DnaJ
- Probable GTP-binding protein EngB
- tRNA-specific 2-thiouridylase MnmA
- Large ribosomal subunit protein bL21
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein bL17
Sequence:
MSPSDLHLPVPGHPIAAIATPVGVGALAIVRISGAGVLDLADRVFRKVHGSGKLAEAAGYTAHFGRLYDGEEMVDEVIALVFRAPRSFTAEQMVEFTCHGGPVVVGRVLRLMLDNGCRLAEPGEFTRRAFLNGRIDLLQAEAIGEMIHARTESAYRTAVSQMKGDLSVRLGGLREQLIRSCALIELELDFSEEDVEFQSRDELTMQIETLRSEVNRLIDSYQHGRIVSEGVSTVIAGKPNAGKSTLLNTLLGQERAIVSHMPGTTRDYIEECFIHDKTMFRLTDTAGLREAGEEIEHEGIRRSRMKMAEADLILYLLDLGTERLDDELTEIRELKAAHPAAKFLTVANKLDRAANADALIRAIADGTGTEVIGISALNGDGIDTLKQHMGDLVKNLDKLHEASVLVTSLRHYEALRNASDALQNALELIAHESETELIAFELRAALDYVGQITGKVVNEEVLNTIFDKFCIGK
Protein: Crooked neck-like protein 1 (Crooked neck homolog) (Q54XP4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in pre-mRNA splicing process.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9BZJ0}. Nucleus speckle {ECO:0000250|UniProtKB:Q9BZJ0}. Note=Colocalizes with core spliceosomal snRNP proteins. {ECO:0000250|UniProtKB:Q9BZJ0}.
Interaction partners:
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-splicing factor ISY1 homolog
- Protein snwA
- Cell division cycle 5-like protein
- Protein BUD31 homolog
- 116 kDa U5 small nuclear ribonucleoprotein component
- Small nuclear ribonucleoprotein F
- WD40 repeat-containing protein
- Pre-mRNA-processing factor 19
Sequence:
MNQNRTGGVSKVKNKSAAPVQITAEQILRVAHENQQTLPKAPPKQVITDQEELEDYRLRKRQQYESLLGRNRKTAAIYIKYAAWEESQKDLTRARSVFERFLDIDHRIPTVWIKYAEMEMKNKNINLARNIWDRAVCLLPRVSQLWFKYTFMEDMLGNYPAARAIFERWMQWKPEPQAWNSYLKFEQRLKLFENTRLIFEKYILVHPYIKTWIKYTKFEERLGNIENARTIFQRAIEFLGEDGNDEQLFIAFAKFEEKYKEIERARVIYKYAIDHVPKSRAKDLFDTFTNFEKQHGDRIGIEDVVLGKKRFQYEEEIKKNSKNYDIWFDYLKMEEINGEIEKTREIYERSIGNLPPTNEKKHWKRYIYLWINYALFEELISKDMERARSVYSECIKLIPHKEFSFSKIWILYANFEIRQLNLDKARLIYGQAIGRNPKSKIFDQYIHLEIELGNFDRVRTLYEKYLEIMPDNCDAWCKFAQLETELGETVRARAIFELAIQQPNLDRPEVVWKDFIDSEIQLKQFDFVKQLYRKLLEKTNHVKVWIGFIKFVHSIKDKQQQKQRQQQQEEDGDSNTTKKDGGDDDNNDDINKPTREIFIEAHKSLSNSDKEERLLLLESWKEFEQTFGNQETLNQVLKKIPQRVIKRRSDGNGGIEEYFDYIFPEEEKSTQTSLKLLEAAQRWKKLKQQQELQKQQELQKQQQDS
Protein: WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) (O13046)
Organism: Xenopus laevis (African clawed frog)
Function: Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:9175701}. Cytoplasm {ECO:0000269|PubMed:9175701}. Note=Transiently cytoplasmic during mitosis.
Interaction partners:
Sequence:
MPAIKKNMRYGHPEGHTDVCFDDSGNFLVTCGSDGDIRIWESLDDDDPKSISIGEKAYSFALKNGKVVTAASNNAIQLHTFPDGEPDGILTRFTTNANHVVFNTDGTRIAAGSGDFLVKVLQVEDSTQQKTLRGHSAPVLSVSFDPKDIYLASASCDGSVRIWKISDQTCEAVLPLLEKCNDVFNAKSICRLAWQPKSGKFVAIPVGKAVHLYDRDSLKNICTLSDDFITQPVNIVAWSPCGQYLVAGSVDGCIVAWNIATKACLERIKHEKGYTICALAWHPHLPQIAYTDNEGNLGLLEDVCQGDVKQPSAKVSSAETKDYDELFDGDDDEDFLNGDMIGHEGAVNDEDDDDNFTALTGRPRNRGAIFDDDISSDVPSLKLVGNENPVVEDDQASSVQNFTSVASVKLSYNGPMPTPQQKPFQSGSTPVHLMHRFMVWNSVGVIRCYNDEQDNAIDVEFHDTSIHHAIHLTNSLNHTLADVSQEAVLLACETTEELASKLQCLHFSSWDTSKEWMVDMPKGENIQAICLGQGWVACATSALLIRIFSVGGVQKELISLFGPVVCMASHGEQLIVVYHRGMGFDGDQCLGVQLLELGKKKKQVLHGDPLPLSRKSYLSWLGFTAEGSPCYVDSEGIVRLLNRSLGDTWVPICNTREHCKGKSDHYWVVGIHENPQQVRCIPCKGSRFPPTLPRPAVAVLPFNLPYCQITTEKGQMEEQYWRSQIFSNHSDYLSKHGYECDENFKAEAQKMQQELLMKMFALSCKLEREFRCMELAEFMTQNVMNLAIKYASRSKRLILAQRLSEMALEKAAEQASAEQNEEEDEEEEDFRSRLTAGYSRTATEWGDSRAKPVKQDQYEENNEEEMEEEEKEQEEALESNTPTANPFNKSVKTPDVSESKLGAILSSNQGRVNPFKVSASQKSPAFASNSSRSTSILDNMGKFPRKPSASGSPSTSKSDSVIIKPLAPKAKSKQGQATLFHSVQAKPIAKKTTEEKKAVPTPPKAAADIAENKKPKTGFQLWLDENRPSILSENAGLDESEIIKEGMSRFRMLTSEERMLWTEKAKGDYPGEDGADAKKRKRPEQENMASNGCPQENTDSGIAAAKKHKPLGQSANNKLSAFAFKKE
Protein: Cilia- and flagella-associated protein 69 (Q8BH53)
Organism: Mus musculus (Mouse)
Function: Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways. Required for sperm flagellum assembly and stability.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:28495971}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:29606301}. Note=Localizes to the midpiece of the sperm flagellum. {ECO:0000269|PubMed:29606301}.
Interaction partners:
- Cilia- and flagella-associated protein 44
- Cilia- and flagella-associated protein 43
- Cilia- and flagella-associated protein 251
- Cilia- and flagella-associated protein 65
- Fibrous sheath-interacting protein 2
- Cilia- and flagella-associated protein 70
- Dynein axonemal heavy chain 1
- Armadillo repeat-containing protein 2
- Sperm flagellar protein 2
- Tetratricopeptide repeat protein 21A
Sequence:
MSTAEASATTADAAEAGGRTKTGSPRTIPVFGVAIPDGEMQGIFKPMDLNRIIKVLEEEDKDVSEEKQLNYIKKLIHCYQNGFPLRDLAQIFKILSLCAEKIEKQPCFVEPASDIIKLCGLPFLKKKVSDEITYTEDTANSFALLGELMKIPSSALRIQICKCIVDFYHAEPLKKHIPGYQQVSSSYKIKMVEVGGLAKAMVQSALLLENQLVEKLWVLKVLQHLSTSGVNCTLMVKAQAASGICAHLNDPDPSGQLLFRSSEVLWNLLEKSSKEEIIQQLSNLECLLALKEVFKNLFVRGHSHYERQLRNDILVITTIIAQNPGAPMIECGFTRDLILFATFNEVKSQNPLVKSLKLFNCYEDFELKKLLFNIIVILCKDLATVQLLIDGKVILALFTYVKKPERLKIMEWSAAQYEELQLHAIATLSSVAPLLIEEYMSCHGNSRILAFLEWCGHEDSYFIHGNSFHGTGGRGNKFAQMRYTLRLLRAMVYLEDETVNKDLCERGVIHQLIEIFKTMMSRPAEKEEAIALEIQSDTLLILSGLCENYIQRKEMFGTEGVDIVLHVMKTDPKNLQRGLGYNVLLFSTLDSIWCCILGCYDSEDYFLEKEGIFLLLDILALNQKKFCNLILGIMVEFCDNPKTSAHVNAWRGKKDLTAASLLIKLWRKEEKELGVKRDRNGKIVDTKRPLFTSFQEEQKTMPLPANCPSIAVMDVAENIRAKIYAVLDKLDFENLPGLSAEDFVTLCIIHRYFDFKIGEIWNEVSEEIKLEKLRLVTTDEKSLNSIIAATENIGKMVASLQSEMIENQALQDVQNEQRVYAKIQATHKQREQANKSWENFLARTSNAKTLKKAKKLQEKAIESSRYTERPQNATFHQTVIKGLNTTVPSGRVVTVQSTPTRLLGGPLADTDIALKKLPIRGGALQRVKVKPPLNDPKKSIPT
Protein: Polycomb group RING finger protein 3 (RING finger protein 3A) (Q3KNV8)
Organism: Homo sapiens (Human)
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:21282530}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8BTQ0}. Note=Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. {ECO:0000250|UniProtKB:Q8BTQ0}.
Interaction partners:
- E3 ubiquitin-protein ligase RING1
- E3 ubiquitin-protein ligase RING2
- Polycomb group RING finger protein 5
- RING1 and YY1-binding protein
- Polycomb group RING finger protein 2
- Chromobox protein homolog 7
- Chromobox protein homolog 6
- Chromobox protein homolog 8
- Polycomb group RING finger protein 1
- Polycomb group RING finger protein 6
Sequence:
MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL
Protein: Uncharacterized protein (Q582T8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTVKRETESILAIADEVIASIEGYPRKDKLQQPSIEGKPVVAPPSSFSKSIQTESKIFSKGVQHSIYLKDVGIQCAQQPTNRDTQTECFTFSSSTQTEPDTTLVSVRRGIKDVTKNFAEKSEYMERLLECLAVRLDRCRTNVHKVATQLADLAASRRILEQGLNDIRVGNSITRLIQQETEVRNFLWDEEHVSRNEVVMLALSEMRGYYVKHTSPLLENRCECVPNTDDPSLVQKCVSGATTLPTSDCTDVDEYLQYNPVSNLVSEQGEYFKDMEMLLSECLAVLGKENIAHLSSACL
Protein: Unconventional myosin-Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC) (Q9UBC5)
Organism: Homo sapiens (Human)
Function: Involved in directing the movement of organelles along actin filaments.
Interaction partners:
- Actin, cytoplasmic 2
- Myosin-IIIa
- Unconventional myosin-VI
- Unconventional myosin-Ic
- PDZ and LIM domain protein 4
- CD2-associated protein
- Ras-related C3 botulinum toxin substrate 3
- Espin
- Calmodulin-like protein 3
- Calmodulin-like protein 5
Sequence:
MPLLEGSVGVEDLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKYQDYTFYELKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKGERNFHIFYQLLAGADEQLLKALKLERDTTGYAYLNHEVSRVDGMDDASSFRAVQSAMAVIGFSEEEIRQVLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREIGEMVGLNSEEVERALCSRTMETAKEKVVTALNVMQAQYARDALAKNIYSRLFDWIVNRINESIKVGIGEKKKVMGVLDIYGFEILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIEHNQRGILAMLDEECLRPGVVSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYAGKVTYNVTSFIDKNNDLLFRDLLQAMWKAQHPLLRSLFPEGNPKQASLKRPPTAGAQFKSSVAILMKNLYSKSPNYIRCIKPNEHQQRGQFSSDLVATQARYLGLLENVRVRRAGYAHRQGYGPFLERYRLLSRSTWPHWNGGDREGVEKVLGELSMSSGELAFGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKIYRGWRCRTHYQLMRKSQILISSWFRGNMQKKCYGKIKASVLLIQAFVRGWKARKNYRKYFRSEAALTLADFIYKSMVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQELQQLFYQWKCKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGEEGPVLMAEAVKKVNRGNGKTSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVTVTEKFSVRFKENSVAVKVVQGPAGGDNSKLRYKKKGSHCLEVTVQ
Protein: Beta-catenin homolog sys-1 (Symmetrical sister cell hermaphrodite gonad defect protein sys-1) (Q9XVI2)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000269|PubMed:17296929, ECO:0000269|PubMed:17567664, ECO:0000269|PubMed:19386265, ECO:0000269|PubMed:26073017}. Cytoplasm {ECO:0000269|PubMed:17296929, ECO:0000269|PubMed:17567664}. Cytoplasmic granule {ECO:0000269|PubMed:17296929}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17296929, ECO:0000269|PubMed:17567664}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:35196020}. Note=Centrosomal localization increases at metaphase (PubMed:17567664). Maintenance of centrosomal localization requires trafficking of sys-1 by microtubule motor dynein and may enhance proteasomal degradation of sys-1 (PubMed:35196020). Localized to nucleus in a Wnt signal- and pop-1-dependent manner (PubMed:17567664). {ECO:0000269|PubMed:17567664, ECO:0000269|PubMed:35196020}.
Interaction partners:
- Protein pop-1
- Armadillo repeat-containing protein wrm-1
- Adenomatous polyposis coli protein-related protein 1
- Serine/threonine kinase NLK
- Beta-catenin/armadillo-related protein 1
- DiSHevelled related
- Protein mom-2
- Uracil phosphoribosyltransferase homolog
- Segment polarity protein dishevelled homolog mig-5
- Axin-like protein pry-1
Sequence:
MHSTGEPQRGPAGPYHHPMPYHVDQIPTTSHPSWHQAPHPGLPTPPYHPQQHPNYISMQPPPSQQQQMTPQALSTQQQQQVQQQQQRQLYSSPSPSRGPAAPAQNQKFRTEQWINNQAWPYSQSPAPPVAPSVMSYHQGDDRMSMLSVNTTMTNQFPDSQRCYSSNGSTCENVNPEMMQMNITQAAEQAIRLWFNTPDPMQRLHMAKTIRTWIRQDKFAQVDQANMPNCVQQILNIIYDGLKPQPVQLPISYYAQLWYNLLDILRRFTFLPIISPYIHQVVQMFCPRENGPQDFRELICNLISLNWQKDPHMKHCANQVFQIFNCIIMGVKNEKLRTEFAQHLKFEKLVGTLSEYFNPQVHPGMINPAIFIIFRFIISKDTRLKDYFIWNNNPHDQPPPPTGLIIKLNAVMIGSYRLIAGQNPETLPQNPELAHLIQVIIRTFDLLGLLLHDSDAIDGFVRSDGVGAITTVVQYPNNDLIRAGCKLLLQVSDAKALAKTPLENILPFLLRLIEIHPDDEVIYSGTGFLSNVVAHKQHVKDIAIRSNAIFLLHTIISKYPRLDELTDAPKRNRVCEIICNCLRTLNNFLMMWIPTPNGETKTAGPNEKQQVCKFIEIDILKKLMSCLSCEGMDTPGLLELRSTILRSFILLLRTPFVPKDGVLNVIDENRKENLIGHICAAYSWVFRQPNNTRTQSTKQQLVERTISLLLVLMEQCGAEKEVAQYSYSIDCPLNLLNGNQVKPTFIHNVLVVCDKILEHCPTRADIWTIDRPMLEGLTNHRNSDIAKAANSLLSRFPENDLLAGIFSNREYF
Protein: Cullin 9 (E9PEZ1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVGERHAGDLMVPLGPRLQAYPEELIRQRPGHDGHPEYLIRWSVLKCGEVGKVGVEEGKAEHILMWLSAPEVYANCPGLLGERALSKGLQHEPAGVSGSFPRDPGGLDEVAMGEMEADVQALVRRAARQLAESGTPSLTAAVLHTIHVLSAYASIGPLTGVFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAHVLLSLSQQDGIEQHMDFDSRYTLLELFAETTSSEEHCMAFEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLNSSPELGAGDQSSPCATREKSRGQRELEFSMAVGNLISELVRSMGWARNLSEQGMSPPRPTRSIFQPYISGPSLLLPTIVTTPRRQGWVFRQRSEFSSRSGYGEYVQQTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGIPPVQVFWQSTGRTYWVHWHMLEILGPEEATEDKASAAVEKGAGATVLGTAFPSWDWNPMDGLYPLPYLQPEPQKNERVGYLTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLDETLGEKALGEISVSVEMAESLLQVLSSRFEGSTLNDLLNSQIYTKYGLLSNEPSSSSTSRNHSCTPDPEEESKSEASFSEEETESLKAKAEAPKTEAEPTKTRTETPMAQSDSQLFNQLLVTEGMTLPTEMKEAASEMARALRGPGPRSSLDQHVAAVVATVQISSLDTNLQLSGLSALSQAVEEVTERDHPLVRPDRSLREKLVKMLVELLTNQVGEKMVVVQALRLLYLLMTKHEWRPLFAREGGIYAVLVCMQEYKTSVLVQQAGLAALKMLAVASSSEIPTFVTGRDSIHSLFDAQMTREIFASIDSATRPGSESLLLTVPAAVILMLNTEGCSSAARNGLLLLNLLLCNHHTLGDQIITQELRDTLFRHSGIAPRTEPMPTTRTILMMLLNRYSEPPGSPERAALETPIIQGQDGSPELLIRSLVGGPSAELLLDLERVLCREGSPGGAVRPLLKRLQQETQPFLLLLRTLDAPGPNKTLLLSVLRVITRLLDFPEAMVLPWHEVLEPCLNCLSGPSSDSEIVQELTCFLHRLASMHKDYAVVLCCLGAKEILSKVLDKHSAQLLLGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRTHQPINIPFFDVFLRHLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGSTGSHYITLHMHRGVLVRQLTLLVASEDSSYMPARVVVFGGDSTSCIGTELNTVNVMPSASRVILLENLNRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTIRAQAWSRDIAEDHRRLLQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLVQNITSPDAEGVSALGWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPPGPSPEPSTRPFSKNSKGRDRSPAPSPVLPSSSLRNITQCWLSVVQEQVSRFLAAAWRAPDFVPRYCKLYEHLQRAGSELFGPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARYIDQQIQGGLIGGAPGVEMLGQLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFGSSWLEGAVLEQIGLCFPNRLPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEEEKRLEEEEEEEEEEEAEKELFIEDPSPAISILVLSPRCWPVSPLCYLYHPRKCLPTEFCDALDRFSSFYSQSQNHPVLDMGPHRRLQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQTEEVSVETLLKDSDLSPELLLQALVPLTSGNGPLTLHEGQDFPHGEKDEGRTLEQKRNLLSCLLVRILKAHGEKGLHIDQLVCLVLEAWQKGPNPPGTLGHTVAGGVACTSTDVLSCILHLLGQGYVKRRDDRPQILMYAAPEPMGPCRGQADVPFCGSQSETSKPSPEAVATLASLQLPAGRTMSPQEVEGLMKQTVRQVQETLNLEPDVAQHLLAHSHWGAEQLLQSYSEDPEPLLLAAGLCVHQAQAVPVRPDHCPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGTTCSKCGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCSAMVSKAARQEKRFQDYNERCTFHHQAREFAVNLRNRVSAIHEVPPPRSFTFLNDACQGLEQARKVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRLLRADCLSTGMELLRRIQERLLAILQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFFFGDEEEDEDEAYD
Protein: Pentatricopeptide repeat-containing protein At1g13040, mitochondrial (Q9SAD9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- F3F19.7
- Eukaryotic translation initiation factor 4B2
- Uncharacterized protein At1g63310
- Proteasome subunit beta type-5-A
- Coilin
- Nucleic acid-binding, OB-fold-like protein
- Protein PARTING DANCERS
- E3 ubiquitin-protein ligase At1g12760
Sequence:
MHQTLGAVRLAYRSRIANLVKSGMIDNAVQVFDEMRHSSYRVFSFDYNRFIGVLVRESRFELAEAIYWDMKPMGFSLIPFTYSRFISGLCKVKKFDLIDALLSDMETLGFIPDIWAFNVYLDLLCRENKVGFAVQTFFCMVQRGREPDVVSYTILINGLFRAGKVTDAVEIWNAMIRSGVSPDNKACAALVVGLCHARKVDLAYEMVAEEIKSARVKLSTVVYNALISGFCKAGRIEKAEALKSYMSKIGCEPDLVTYNVLLNYYYDNNMLKRAEGVMAEMVRSGIQLDAYSYNQLLKRHCRVSHPDKCYNFMVKEMEPRGFCDVVSYSTLIETFCRASNTRKAYRLFEEMRQKGMVMNVVTYTSLIKAFLREGNSSVAKKLLDQMTELGLSPDRIFYTTILDHLCKSGNVDKAYGVFNDMIEHEITPDAISYNSLISGLCRSGRVTEAIKLFEDMKGKECCPDELTFKFIIGGLIRGKKLSAAYKVWDQMMDKGFTLDRDVSDTLIKASCSMSADA
Protein: Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) (O14879)
Organism: Homo sapiens (Human)
Function: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:18706081}. Mitochondrion {ECO:0000269|PubMed:21813773}.
Interaction partners:
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Antiviral innate immune response effector IFIT1
- Interferon-induced protein with tetratricopeptide repeats 2
- Signal transducer and activator of transcription 1-alpha/beta
- Interferon-induced protein 44
- Interferon-induced protein 44-like
- Ubiquitin-like protein ISG15
- Interferon-induced helicase C domain-containing protein 1
- Interferon-induced GTP-binding protein Mx1
- Antiviral innate immune response receptor RIG-I
Sequence:
MSEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEMGQGAVSSSPRELLSNSEQLN
Protein: Ras-related protein Rab-4B (EC 3.6.5.2) (P51146)
Organism: Rattus norvegicus (Rat)
Function: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Protein transport. Probably involved in vesicular traffic (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P61018}; Lipid-anchor {ECO:0000250|UniProtKB:P61018}; Cytoplasmic side {ECO:0000250|UniProtKB:P61018}. Early endosome membrane {ECO:0000250|UniProtKB:P61018}; Lipid-anchor {ECO:0000250|UniProtKB:P61018}; Cytoplasmic side {ECO:0000250|UniProtKB:P61018}.
Interaction partners:
- Rabenosyn, RAB effector
- ADP-ribosylation factor 6
- Rab GTPase-binding effector protein 1
Sequence:
MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDISLRQLRQPRSAQAVAPQPCGC
Protein: AT22731p (Q8T414)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MISPGYQRLGPSLDRVPDDEETDSQEEEMEILPCGMGEEGITTDEETKTLITIQGLDEILKRIDILRSQLRRNQQLEDISQPSVMPEDPISCSGLNAKQSEIRCIQRAQHHIQCQLTELLCRYDALRNMLRSLGETWTCLERRIADIRGQNRVHLAWTEECANDLSNCQQRHRSLAAVKLTKKMALLVTKTNMSSGFRYSRRYLRHALIARHINDFRYEIAELKVLSEEIFSEIDGRLDQIKMKAQRFGVVFSTTPRQSNLIADGTGNTELTELTDATETFTVPRSNNPK
Protein: Angio associated migratory cell protein (H7C0R2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XIHVLKGIRGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR
Protein: D-xylulose reductase (EC 1.1.1.9) (Xylitol dehydrogenase A) (Q876R2)
Organism: Hypocrea jecorina (Trichoderma reesei)
Interaction partners:
Sequence:
MATQTINKDAISNLSFVLNKPGDVTFEERPKPTITDPNDVLVAVNYTGICGSDVHYWVHGAIGHFVVKDPMVLGHESAGTVVEVGPAVKSLKPGDRVALEPGYPCRRCSFCRAGKYNLCPDMVFAATPPYHGTLTGLWAAPADFCYKLPDGVSLQEGALIEPLAVAVHIVKQARVQPGQSVVVMGAGPVGLLCAAVAKAYGASTIVSVDIVQSKLDFARGFCSTHTYVSQRISAEDNAKAIKELAGLPGGADVVIDASGAEPSIQTSIHVVRMGGTYVQGGMGKSDITFPIMAMCLKEVTVRGSFRYGAGDYELAVELVRTGRVDVKKLITGTVSFKQAEEAFQKVKSGEAIKILIAGPNEKV