wanglab/gogpt-training-data huggingface dataset:
Protein: Anthocyanidin 3-O-glucosyltransferase UFGT (EC 2.4.1.115) (Flavonol 3-O-glucosyltransferase) (EC 2.4.1.91) (UDP-glucose flavonoid 3-O-glucosyltransferase) (P51094)
Organism: Vitis vinifera (Grape)
Function: In the presence of other necessary color factors, this glycosylation reaction allows the accumulation of anthocyanin pigments (Probable). Involved in the formation of red wine pigments (Probable). UDP-glucose (UDP-Glc) is the physiological sugar donor, and cyanidin is the natural acceptor in vivo. Can glucosylate the anthocyanidins delphinidin, peonidin, pelargonidin and malvidin. The flavonols quercitin and kaempferol can also be glucosylated in vitro, but with glucosylation rates 50-100 times lower than cyanidin. In vitro, can use UDP-Glc, UDP-5SGlc, UDP-Xyl, UDP-Man, UDP-Gal, UDP-GlcNAc, GDP-Glc, dTDP-Glc and dTDP-Xyl as sugar donors, but not UDP-6OMeGal, UDP-Ara, UDP-6FGal, UDP-GlcN, UDP-2FGal, UDP-5SAra, GDP-Man, GDP-Fuc, UDP-Fuc or UDP-Rha.
Interaction partners:
Sequence:
MSQTTTNPHVAVLAFPFSTHAAPLLAVVRRLAAAAPHAVFSFFSTSQSNASIFHDSMHTMQCNIKSYDISDGVPEGYVFAGRPQEDIELFTRAAPESFRQGMVMAVAETGRPVSCLVADAFIWFAADMAAEMGLAWLPFWTAGPNSLSTHVYIDEIREKIGVSGIQGREDELLNFIPGMSKVRFRDLQEGIVFGNLNSLFSRMLHRMGQVLPKATAVFINSFEELDDSLTNDLKSKLKTYLNIGPFNLITPPPVVPNTTGCLQWLKERKPTSVVYISFGTVTTPPPAEVVALSEALEASRVPFIWSLRDKARVHLPEGFLEKTRGYGMVVPWAPQAEVLAHEAVGAFVTHCGWNSLWESVAGGVPLICRPFFGDQRLNGRMVEDVLEIGVRIEGGVFTKSGLMSCFDQILSQEKGKKLRENLRALRETADRAVGPKGSSTENFITLVDLVSKPKDV
Protein: Kinesin-like protein KIN-4A (Protein BRITTLE CULM 2) (Protein GIBBERELLIN-DEFICIENT DWARF 1) (Q6YUL8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Microtubule-dependent motor protein involved in the control of the oriented deposition of cellulose microfibrils. Involved in wall biogenesis and modification, and contributes to cell-cycle progression and cell division. Acts as a transcriptional activator in gibberellic acid (GA) biosynthesis pathway. Binds specifically to the DNA sequence 5'-ACCAACTTGAA-3' of the ent-kaurene oxidase 2 (CYP701A6 or OsKO2) promoter. May regulate CYP701A6 gene expression and mediates cell elongation by regulating the GA biosynthesis pathway.
Subcellular location: Nucleus {ECO:0000269|PubMed:20444225, ECO:0000269|PubMed:21325138}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:20444225, ECO:0000305|PubMed:21325138}. Note=Associated with mitotic microtubule arrays during cell division. {ECO:0000269|PubMed:20444225}.
Interaction partners:
- Kinesin-like protein KIN-10A
- Kinesin-like protein KIN-5C
- Kinesin-like protein KIN-5B
- Kinesin-like protein KIN-5A
- Os06g0256000 protein
- Kinetochore protein NDC80
- E2 ubiquitin-conjugating enzyme
- Os03g0704400 protein
- Condensin complex subunit 2
- Kinesin-like protein KIN-UB
Sequence:
MTMEHGEDCCVKVAVHVRPLIGDEKLQGCKDCVSVVSGKPQVQIGSHSFTFDHVYGSSGTPSAAMFEECVAPLVDGLFQGYNATVLAYGQTGSGKTYTMGTACKEGSHIGIIPRAMATLFDKIDKLKNQVEFQLRVSFIEILKEEVRDLLDPATAAVGKLENGNGHATKLSVPGKPPVQIREASNGVITLAGSTEVHVTTQKEMTACLEQGSLSRATGSTNMNNQSSRSHAIFTITLEQMRKADPIMTLDGMPIEEMNEDYLCAKLHLVDLAGSERAKRTGSDGLRFKEGVHINRGLLALGNVISALGDEKKRKEGAHVPYRDSKLTRLLQDSLGGNSKTVMIACISPADINAEETLNTLKYANRARNIQNKPIVNRNPVADEMKRMRQQIEYLQAELVSARGGVVLDDVQGLRERISMLEQKNEDLCRELYDLRNHGYTDPCEPELQKIGTGYTKGEGLKRSLQSTEPFDVPMTDSVRAGSPKDIDDEVAKEWEHTMLQDSMGKELNELNRQLEQKESEMKMYGSDTVALKQHFGKKLLELEEEKRAVQQERDRLLAEVESLNADGQTHKLRDAQLQKLKTLEAQILDLKKKQENQVQLLKEKQKSDEAAKKLQEEIHSIKAQKVQLQHKIKQEAEQFRQWKATREKELLQLRKEGRRNEYERHKLQALNQRQKLVLQRKTEEAAMATKRLKELLEARKSSGRDNSGMNGTSPGSHMTEKSLQKWLEQDLEVMVHVHEVRNEYEKQSQLRAALGEELAILKQEDVMSGAASPPRGKNGNSRANTLSPNARQARIASLESMVTISSNTLVAMASQLSEAEERERAFSGRGRWNQLRSMAEAKSLLQYIFNVAADARCQVREKEMEIKEMKEQMTELVTILRHSESRRRETEKQLKQREQAAVTATTSPGNGNGSVKHSADDSNTPLSPVAVPAQKQLKYSAGIVNSPSKGVPAFNKQHLKMVPMAQLPVGKKVSIAGQSGKLWRWKRSHHQWLLQFKWKWQKPWKLSEMIRHSDETMTRTRPRPQLLPHRPQRVM
Protein: High glucose sensor RGT2 (Low-affinity glucose receptor RGT2) (Low-affinity transporter-like sensor RGT2) (Restores glucose transport protein 2) (Q12300)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Low-affinity high glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell. The transporter-like sensor generates an intracellular signal in the presence of high levels of glucose to promote high glucose-induced expression of HXT1. Binding of glucose to the RGT2 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane. Even though RGT2 is similar to glucose transporters, it appears to be unable to transport glucose.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8901598}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Hexokinase-2
- Carbon catabolite-derepressing protein kinase
- G protein-coupled receptor GPR1
- Glucokinase-1
- Hexokinase-1
- Glucose transport transcription regulator RGT1
- Protein STD1
- Low glucose sensor SNF3
- Guanine nucleotide-binding protein alpha-2 subunit
- Regulatory protein MIG1
Sequence:
MNDSQNCLRQREENSHLNPGNDFGHHQGAECTINHNNMPHRNAYTESTNDTEAKSIVMCDDPNAYQISYTNNEPAGDGAIETTSILLSQPLPLRSNVMSVLVGIFVAVGGFLFGYDTGLINSITDMPYVKTYIAPNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRGLPIEDPRLLEELVEIKATYDYEASFGPSTLLDCFKTSENRPKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTSSMGPKIFFIWGGLNVVAVIVVYFAVYETRGLTLEEIDELFRKAPNSVISSKWNKKIRKRCLAFPISQQIEMKTNIKNAGKLDNNNSPIVQDDSHNIIDVDGFLENQIQSNDHMIAADKGSGSLVNIIDTAPLTSTEFKPVEHPPVNYVDLGNGLGLNTYNRGPPSIISDSTDEFYEENDSSYYNNNTERNGANSVNTYMAQLINSSSTTSNDTSFSPSHNSNARTSSNWTSDLASKHSQYTSPQ
Protein: Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) (Q96EE3)
Organism: Homo sapiens (Human)
Function: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}. Lysosome membrane {ECO:0000269|PubMed:28199306}.
Interaction partners:
- GATOR1 complex protein NPRL2
- Nuclear pore complex protein Nup155
- Nuclear pore complex protein Nup205
- GATOR2 complex protein MIOS
- Nuclear pore complex protein Nup133
- Nucleoporin Nup43
- Nuclear pore complex protein Nup98-Nup96
- GATOR2 complex protein WDR59
- Nuclear pore complex protein Nup107
- GATOR2 complex protein WDR24
Sequence:
MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRKHS
Protein: Des-methyl DIF-1 methyltransferase A (EC 2.1.1.-) (O-methyltransferase 8) (Q8T638)
Organism: Dictyostelium discoideum (Social amoeba)
Function: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of DIF-1 (Differentiation Inducing Factor-1), a signal molecule involved in the differentiation of pstO (prestalk-O) cells. The three-step process begins with the formation of (2,4,6-trihydroxyphenyl)-1-hexan-1-one (THPH) by the polyketide synthase StlB. THPH is then dichlorinated by the flavin-dependent halogenase ChlA. The last step of DIF-1 biosynthesis is the O-methylation of dichloro-THPH (or des-methyl-DIF-1) by the methyltransferase DmtA to yield DIF-1.
Interaction partners:
- Tryptophan 2,3-dioxygenase
- Polyketide synthase 37
- Basic-leucine zipper transcription factor B
- Myb domain-containing protein
Sequence:
MISNSDCDENLIKQQQQEIQDKNFLIDVAIGYTKSNALSCALKYKIPQLLEDKSKSCKELSEILKVNCDNLYRLLRTLSTIGIFIEDEVEDGVFRNSRLSNLLRNSNSDSWVNNVYLQSHPNVIQSFMYLDKTIECGTSQGMTSQGFSSAWELFEKDKSLNAHFHNTMTSFTSDEIKTILEYIDFNQYKSIVDLGGSSGELLKSIAKSSRGQLVESFINFDLPLVINQNKVNNENGAAEFDKRYSEVASDLFVDSDYPSADCYTLKFIFHMFNDDKVLTILDKISKSIKPNGKVYVFDHIVQPKNQPYAPFYFDLQMIVNFNGKERSQNEWKTIFEKSPFKIDTILILPDSKRMSVIELSLKQ
Protein: Methyl-CpG-binding domain-containing protein 1 (AtMBD1) (MBD01) (Methyl-CpG-binding protein MBD1) (Q5XEN5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcriptional regulator.
Subcellular location: Nucleus {ECO:0000269|PubMed:14605234}.
Interaction partners:
- Methyl-CpG-binding domain-containing protein 6
- Methyl-CpG-binding domain-containing protein 5
- Methyl-CpG-binding domain-containing protein 7
- Methyl-CpG-binding domain-containing protein 8
- Methyl-CpG-binding domain-containing protein 13
- Heptahelical transmembrane protein 1
- Methyl-CpG-binding domain-containing protein 10
- Methyl-CpG-binding domain-containing protein 11
- Methyl-CpG-binding domain-containing protein 9
Sequence:
MLPFPAMNLKKSRSENSSVASSGSKIEEQTEKSAEPTTIKVQKKAGTPGRSIDVFAVQCEKCMKWRKIDTQDEYEDIRSRVQEDPFFCKTKEGVSCEDVGDLNYDSSRTWVIDKPGLPRTPRGFKRSLILRKDYSKMDAYYITPTGKKLKSRNEIAAFIDANQDYKYALLGDFNFTVPKVMEETVPSGILSDRTPKPSRKVTID
Protein: phosphoenolpyruvate--protein phosphotransferase (EC 2.7.3.9) (Q9HXN5)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- phosphoenolpyruvate--protein phosphotransferase
- N-Acetyl-D-Glucosamine phosphotransferase system transporter
- Phosphocarrier protein HPr
- protein-N
- Probable N-acetylglucosamine-6-phosphate deacetylase
- HTH-type transcriptional regulator GntR
- Fructose transport system repressor FruR
- Ribose operon repressor RbsR
- Nitrogen regulatory protein
- Phosphofructokinase
Sequence:
MNNKNLALKAPLSGPVMPLNRVPDPVFSSGTLGEGIAIDPLNDCLHAPCAGLVSHLARTRHALSLRADNGAELLLHVGLDTVQLQGEGFEALVEEGARVIEGQPLLRFDLDRVARGSRSLITVMILTNGDGFQVRPLTTNPVEVGAPLLQLSPEKAEQRPANPAPGEGSAQRQVRGRARVAHHGGLHARPAALLRKTAQGFSSQAELHFAGQVASVDSLVGIMGLGVAEQDEVEVICRGEDSEAALGALLAALASATAGAPKDAPRAIAPGEPARPAAVAGTLAGVCASPGLASGPLARLGAISLPADDGRHRPEEQHLALDQALQRVRDDVQGSLQQARLGGDENEAAIFSAHLALLEDPGLLDAADMLIDQGVGAAHAWHRAIQAQCEILQALGNLLLAERANDLRDLEKRVLRVLLGDTAPLRVPAGAIVAAREITPSDLAPLVDAGAAGLCMAEGGATSHVAILARSKGLPCLVALGAGLLELEEGRQVVLDAGQGRLELSPDARRLEQVALQVAQREEQRRRQQADAQREALTRDGRRIEIGANVASPREAAEAFANGADGVGLLRTEFLFLERRAAPDEEEQRNAYQEVLDAMGQRKVIIRTIDVGGDKHLDYLPLPVEENPALGLRGIHLGQARPELLDQQLRALLRVEPLERCRILLPMVSEVDELRAIRRRLGELATQLGIERLPELGVMIEVPSAALLADQLAEHADFLSIGTNDLSQYALAMDRCHAGLADRIDALHPALLRLIAQTCAGAARHGRWVGVCGALASDPLATPVLVGLGVEELSVGPNLVGEIKTRVRQLDAAECRRHAQALLDLGSARAVRDACLQHWPLA
Protein: Probable UDP-glucose:glycoprotein glucosyltransferase A (EC 2.4.1.-) (Developmental gene 1109 protein) (Q8T191)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum (By similarity).
Subcellular location: Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
- Calnexin
- J domain-containing protein
- Neutral alpha-glucosidase AB
- Protein raptor homolog
- Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Calreticulin
- Small GTPase
- Hisactophilin-3
Sequence:
MARIFKFFVFLLIVFISNVLLLVESNEGDNSFSSKSIQLSLVSNWGETPSYLEAAEFLHNQDKSLFWKFIEEFNKIDFSTNYSDKIYYESTISLMKSVLSSNTQFLSEFLSIDLAMRTYSPRVETYRQLAISNMKLNNIEHSITTADNKTITLFNSGGWVQIKNKIITDVNEINESLFKDVAVVDDEENEFIRLYDFDHIFPTLANTVSSSSSSPSSIPIVILYVDIKSEFFKLVHPKLKQFSQMGKIKYCLRYVVQESNQKLNLQGYGYELSIKNLEYKVMDDSAIKKDIIIDGVKSKTIINIPNEDVQGFNFHKLQKRKPELTSKLSTFRSYLMAKSQEAKELKVWELKDLGIQSAQKIIQSGDPLRSLEYISQKFPTLSNSLSKITLNESLKSVIESNQKIIPSTTDQTLLLNGRLIDTNELSPIELSRIILEEYEHSTTIQQQGPLSSKTVQDIISAQLPIRIQLLPTKEELELNGGNEPFVSLNNLELDYIYRQWEPKLQSSVLDKPVTSPQDIFIRKNLLTTVIVLDWNNINTFEIIPEIQEMVQGNSLIPTRIQLLFNTKSNNNNNNNNNNNDQNSQTSNFIQGKDLAKVFLTIKNSNLGNRGAFFFITALNYFKKMYIPNELGITRSVLSSSFQAVLQQMGGSVRSLQHALTNTDFDNLLESSNQLIERLELLDTTTSQSTTTTTTTKILPKVFVNGVQVKYSNIDQLSFDLLVSLYDEFDNLKPLFKESILSTTTAQYYETILTSSYWKDNNLPFLKKLNSMISNEKYSHLITNSKNRNQEVDAQNVLKNLLYFRNNENKDEQNLLNLIVIGDFDHYNTRDISLELLRQLEKGELKNCKLTFISNPIDINSVVNTAGNENQILGKLITILKHYGKILTPQLVIGLFEKVQSDPTIIDSFKTMKQIIELSGFDIAANDIWVAQSVNLFKQSSKVCKQYLGIQSTNKSPLSILVNGRIITPPLSYDDAASFIQSDFKLLLEIEMIKAKKTFELLNSDPILKDKSNLKISDLLNKVQSLVGYYYNGNNQLDSNIKRKRIPNSLSISFSHKPPTLSSSSSSSSSNSNDVPLKFLMIINPFNKVSQKLVPMVREFSNKLNIPVDVILNPPVSLSELPLKTYYTYVIKLSSEFNNENVLYNQPLGIATDIPEDRVVTLALDIPSSWLVQPIIAKYDLDNIRLKDLGDEQVLTAVYELENIVIEGSANDMTTDNAPAGLELLLNPISTQTNKTQDTIVMNNFGYYQLKSNPGIWKLTIAPGRSSDIMDMVDHPNQKEKETFVIVPHRLVVIDSLYQSLSSLSVVRKAGQELRPILQPIDEYEKQKEQEKEQKLKQNSSGFFSNLFSSKNDATDSVATHQKKSNLDTIHIFSVASGHLYERFLKIMMLSVVKNTESPIKFWFLKNYLSPAFKEFIPEMAKEYGFQYELVTYKWPWWLRKQTEKQRIIWSYKILFLDVLFPLDVPKIIFVDADQVVRTDLKELWDMDLHGASLGYTPFCDSNKDTEGFRFWKSGYWRQHLAGRSYHISALYVVDLVRFRRLAAGDQLRATYDQLSRDPNSLANLDQDLPNYLQHYVRIHSLPQEWLWCETWCDQESKSKAKTIDLCNNPLTKTPKLENAVRIIDEWTTLDNEAKEFELKIDQSKHHRQIELDHQNQLPNSKPIENIDDILLNLAESQKDLF
Protein: thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) (Q8SY26)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRLGQTVPNFEADTTKGPIKFHEWQGNSWVVLFSHPADFTPVCTTELGRIAVHQPEFAKRNTKCLAHSVDALNSHVDWVNDIKSYCLDIPGDFPYPIIADPTRDLAVTLGMLDEEQKKDPRWVRPSAPCSSSVRTIRCASPCFTPCPLVATLTRF
Protein: U6 snRNA-associated Sm-like protein LSm1 (Q9W2K2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU365047}. Cytoplasm, P-body {ECO:0000256|RuleBase:RU365047}.
Interaction partners:
- ATP-dependent RNA helicase me31b
- Protein associated with topo II related - 1, isoform A
- U6 snRNA-associated Sm-like protein LSm5
- U6 snRNA-associated Sm-like protein LSm7
- 5'-3' exoribonuclease 1
- U6 snRNA-associated Sm-like protein LSm2
- U6 snRNA-associated Sm-like protein LSm3
- U6 snRNA-associated Sm-like protein LSm6
- U6 snRNA-associated Sm-like protein LSm4
- U6 snRNA-associated Sm-like protein LSm8
Sequence:
MDDLNPLAGTAHLLEEVDKKLMVLLRDGRTLIGYLRSVDQFANLVLQRTIERIHVGNEYGDIPRGVFIIRGENVVLLGEIDREKEQKLPLKEISVDEILDAQRREQEQRQEKHRLVSKALKERGLAVDANIINEDFC
Protein: Nuclear receptor co-repressor 2 (A0A8I6GHM0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSGSTQPVAQTWRAAEPRYPPHGISYPVQIARPHTPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQRFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMDDPMKVYKDRQVTNMWSEQERDTFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQQMARSSQEEKEEKEKEKEADKEEEKQDAENEKEELSKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANHEETATPQQSSELASMEMNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKTPAAASEETAFPPAAEDEEMEASGASANEEELAEEAEASQASGNEVPRVGECSGPAAVNNSSDTESVPSPRTEATKDAGPKPASTEALPAATQPPVPPPEEPATVPDEPCPAPDASGPPSPVASPPPAAPPAAVDKDEQDQAATVPQTEDAKEQKSEAEELVIDVGKTEEPEAPEEPPESVKSDHKEETEEEPEDKAKGPEAIETVSEAPLKVEEAGSKAAVTKGSSSGATQDSDSSATCSADEVDEPEGGDKGRLLSPRPSLLTPAGDPRASTSPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDTVPPKPAPPVPPPTQHLQPEGDVSQQSGGSPRGKCRSPVPPAEKEAEKASFFPAFPAEGPKLPTEPPRWTSGLPFPIPPREVIKTSPHAADPSAFSYTPPGHPLPLGLHDSARPVLPRPPISNPPPLISSAKHPGVLERQLGTISQQGMSVQLRVPHSEHAKAPMGPLTMGLPLAVDPKKLGTALGSTASGSITKGLPSTRTADGPSYRGSITHGTPADVLYKGTISRIVGEDSPSRLDRAREDTLPKGHVIYEGKKGHVLSYEGGMSVSQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRTITSASIEGLMGRAIPEQHSPHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPPRDLTETYKTRPLDPLGPLKLKPTHEGVVATVKEAGRSIHEIPREELRRTPELPLAPRPLKEGSITQGTPLKYDSGVPSSGSKKHDVRSIIGSPGRPFPALHPLDIMADARALERACYEESLKSRSGTSSGAGGSITRGAPVVVPELGKPRQSPLAYEDHGAPFTSHLPRGSPVTTREPTPRLQEGSLLSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVTGVDLYRGHIPLAFDPTSIPRGIPLEAAAAAYYLPRHLAPSPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAASAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAIDRLAYLPTAPPPFSSRHSSSPLSPGGPTHLAKPTATSSSERERERERERDKSILTSTTTVEHAPIWRPGTEQSSGAGGSSRPASHTHQHSPISPRTQDALQQRPSVLHNTSMKGVVTSVEPGTPTVLRWARSTSTSSPVRPAATFPPATHCPLGGTLEGVYPTLMEPVLLPKETSRVTRPERPRVDAGHAFLTKPPAREPASSPSKSSEPRSLAPPSSSHTAIARTPAKSLAPHHASPDLPAPTSASDLHREKTQSKPFSIQELELRSLGYHSGAGYSPDGVEPISPVSSPSLTHDKGLSKPLEELEKSHLEGELRHKQPGPMKLSGEAAHLPHLRPLPESQPSSSPLLQTAPGIKGHQRVVTLAQHISEVITQDYTRHHPQQLSGPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGTPARGSPHSEGGKRSPEPSKTVLSSSEDAIEPVSPPEGMTEPGHARSTAYPLLYRDGEQGEPRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNIGQPGTEIFNMPAITGAGLMTCRSQAVQEHASTNMGLEAIIRKALMGKYDQWEEPPPLGANAFNPLNASASLPAAAMPITTADGRSDHPLTSPGGGGKAKVSGRPSSRKAKSPAPGLAPGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLAAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE
Protein: Complement C2 (EC 3.4.21.43) (C3/C5 convertase) (A0A8J8YKQ8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MTFSLPWLSRSTVLETMAPLLALLALLQLGPGLAALSCPQNVNIVGGNFTLSRGWAPGSVLIYSCPLGRYPSPAWRECQSNGQWQTPRASSLPTLRSSRLAKAVCKPVRCPAPTSFENGIYIPRLGSYPVGGNLSFECEHGFTLRGSPVRYCRPNGVWDGETAVCDNGASHCPNPGISVGTMRTGSSFDLGDKVSYRCSSTNLVLTGSVERECLSNGVWSGSEPICRREYPQGTPRSPCPALVPADCHFPTEPYSYDFPEDVASALGTSFTHLLGATNPIQKRTENLGRKIQIQRSGHLNLYLLLDASQSVSEKDFNIFKESAFLMVDRIFSFEIKVSVAIITFASRPKIIMSVLNERSQNVMEVMDSLDSVCYKDHENATGTNTYEALNSVYLMMNNQMDRLGMETSAWQEIRHAIILLTDGKSNMGGSPKPAVDNIREILGISRNRNDYLDIYAIGVGKLDVDWKELNELGSKKDGERHAFILQDAKAVQQVFEHILDVSKLTDTICGVGNMSVNASDQERTPWQVTFKPKSKETCQGSLISDQWVLTAAHCFHDAQMEDRHLWRVIVGDPTSHHGKEFHVEEVLVAPGFNVHAKQSQGISEFYADDIALLKLSQRVKMSSHARPICLPCTVGANMALRRSPGSTCKDHETELLSQQKVPAHFVALNGNRMNINLRTGPERTSCIEAVSQNKGSFPGLTNVSEVVTDQFLCSGMEGDDSPCKGESGGAVFLERRYRFFQVGLVSWGLFDPCHGSSNKNLRRKPPHGVVPRDFHISLFRLQPWLRQHLDGVLDFLPL
Protein: S-adenosyl-L-methionine-dependent methyltransferases superfamily protein (Q8L788)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Oleosin family protein
- At5g38020
- Methylsterol monooxygenase 1-3
- Glycine-rich protein / oleosin
- 3-ketoacyl-CoA synthase 16
- Regulator of chromosome condensation
- Glycerophosphodiester phosphodiesterase GDPD6
- Probable glycerol-3-phosphate acyltransferase 3
- At5g48490
Sequence:
MEKIIDVAYGASVKVGLTLLEMNLLPDIVIRRLTRLLLAGRLRSGYKPTAEMQLSDLLRFVDSIKKMPIAIHTEKPKTQHYELPTAFFELVLGRNMKYSSCYFSNDSSSLEDAEEAILALYCERAKVEDGQSVLDIGCGWGSLSLYIARKYSKCKLTGICNSKTQKAFIDEKCRKLGLQNIEIIVADISTFEHEGTYDRIFSIEMFEHMKNYGELLKKIGKWMKEDSLLFVHYFCHKTFAYHFEDVNDDDWITRHFFSGGTMPSADLLLYFQENVSIVDHWLVSGTHYAKTSEEWLKRMDKEIVAVKKIMEVTYGKEEAVKWMVYWRTFFIAVAELFGYNNGEEWMVAHFLFKKK
Protein: High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) (cAMP-specific phosphodiesterase 7A) (Q13946)
Organism: Homo sapiens (Human)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
Subcellular location: [Isoform PDE7A1]: Cytoplasm, cytosol {ECO:0000269|PubMed:9195912}. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. {ECO:0000269|PubMed:9195912}.; SUBCELLULAR LOCATION: [Isoform PDE7A2]: Cytoplasm {ECO:0000269|PubMed:9195912}. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions. {ECO:0000269|PubMed:9195912}.
Interaction partners:
- Alpha-aminoadipic semialdehyde dehydrogenase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenine phosphoribosyltransferase
- Deoxycytidine kinase
- GTP:AMP phosphotransferase AK3, mitochondrial
- Adenylosuccinate lyase
- Adenylate cyclase type 6
- Adenylate cyclase type 5
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
Protein: Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x) (O43298)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MEPGTNSFRVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTVLCQKLNHGSDHQSPSSSSYNGLVESFELGSGGHTDFPKAQELRDGENEEESTKDELSSQLTEHEYLPSNSSTEHDRLSTEMASQDGEEGASDSAEFHYTRPMYSKPSIMAHKRWIHVKPERLEQACEGMDVHATYDEHQVTESINTVQTEHTVQPSGVEEDFHIGEKKVEAEFDEQADESNYDEQVDFYGSSMEEFSGERSDGNLIGHRQEAALAAGYSENIEMVTGIKEEASHLGFSATDKLYPCQCGKSFTHKSQRDRHMSMHLGLRPYGCGVCGKKFKMKHHLVGHMKIHTGIKPYECNICAKRFMWRDSFHRHVTSCTKSYEAAKAEQNTTEAN
Protein: Serine/threonine-protein kinase greatwall (GW) (GWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) (Q6DBX4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of arpp19 and ensa at 'Ser-62' and 'Ser-74', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the ppp2r2d (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity). May be involved in megakaryocyte differentiation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:19460416}. Cleavage furrow {ECO:0000250}. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes (By similarity). Upon mitotic exit moves to the cleavage furrow. {ECO:0000250}.
Interaction partners:
- Alpha-endosulfine
- cAMP-regulated phosphoprotein 19b
- cAMP-regulated phosphoprotein 19a
- Neurobeachin-like protein 2
- Alpha-endosulfine
- Kinesin family member 11
- Dual specificity protein kinase Ttk
- Cyclin A2
- Cell division control protein
- Cyclin-A1
Sequence:
MEARGLACESSNSAVKAPSIEDFVLVKPISRGAFGKVYLARKKCNSKLYAIKVVKKAEMVDKNMTEQMRAERDALALSKSPFIVHLFYSLQTATKVYLVMEYLIGGDVKSLLHIYGYFDEDMSLKYISEVALALDYLHRHSIIHRDLKPDNMLISNEGHIKLTDFGLSKVKLDRELNLMDILTTPSLVKPTKDYFRTPGQVLSLISSLGLNTPVIEGKRHSSTVLGSPMSCGKVKQRNRSLGSPLMKRRAEYMNSPVCTSRALASNSVFSPVLLARSLTPRLLKSGKRLDTMSVGSTHSCMLPSTTDSENCVSPMWEDEQNLHDVENIPQLNGREVDNRKSRNVPLTPVEKRKTLPARAQDHRPVFTPLNNQVTNSRNIKPDLSAKRLQFGATDNSATPLEKTVPHQSVGNGLIKPEPLKELKSSVKRAFEEVEKSPEQAEILFKKNDAAYERSFQIPEKTSRAHTGLTGIFSIVGLDDVKSAPKCQQFNERTGPKQSSPIAVAKNLFCELEDQGEEGGKAEPNSSSSTSPGDERNIRRSLSLESDVSAHEMSLVANTPQKLSDAKQEVLSSSFEELDENEISAVTPMARPTVATPKHSSAKQRRGECERSLLDHPHGLSDSMIKSPGFLKPKNVVAFRSYCSSINRSCTSHLSLASFDAMEMSASASFHNAVTPVQKKRPSLSNSLYQTPQQMVVSHTPYRTPKSVRRGPERVEGAPILGTPDYLAPELLLGKPHDFMVDWWALGVCLFEFLTGVPPFNDETPQLVFQNILNRDIPWPDGEEELTLNSRNAIEILLTMDTLKRAGLKELKDHPFFDGVDWENLHHQTMPFIPQPDNETDTSYFEARNTAQHLTVSGFSL