wanglab/gogpt-training-data huggingface dataset:
Protein: BIG2 domain-containing protein (P91495)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- Nsp1_C domain-containing protein
- Nuclear pore complex protein 14
- Nucleoporin ndc-1
- Nuclear pore complex protein 5
- Nucleoporin SEH1
- Nucleoporin NUP35
- Nuclear pore complex protein Nup98-Nup96
- Nuclear pore complex protein Nup85
- Nuclear Pore complex Protein
- RanBP2-type domain-containing protein
Sequence:
MIILRSLLVLALVQITISYRLNVPRVLLPYHPTVPVSFVLEVTHPTGGCFTWRSTRPDIVSVKRIETNEAGCSDKAEIRSVAKPGTVGSSELSAVIFAEDKGSGTTLSCGVTVDEIATISIETTTKVLFVDAAPARMTVDAFNADGDRFSTLSEIALEWELASTSSNKAKPLRIVPFEQSTYEAPSEIVKLEKNRKKGYLILIEGVGTGTATLTTKFSDAYLQKVAAHNVELAVVANLLLVPSQDVYLPVHSVLPFQVLIVKQRGTEIVNMPNPSYELQIDGGDVASLDKKSSSVRALTIGNTAVHLLSSHVDVRAKAGLRPPSTVIHVVDAESVQWHVSGDNWMLETGKQYTINVELLDEHGNVMFVADNSRFDTHIDEQFLHVDFKSENGTWFLVTPLKPSKTTLRTKFVAIIDAKGNRIAQSGKIGGEQRVTIVDPVRIVPPVIYLPFVSEKRSQIDLTATGGSGLFEWTSEDGHVATVDLLTGRMTANSLGSTKVKATDKRNDQLRDIASVHILEVSGIGFGETVRETFVGDTLTLNIKATGLTSDGLLVEMSDCRNIRAHVQITDNALLRHESSADSSLPMMGTGCGTITFKGLSSGDARVSISYLGHKASIDVAVYEKLSISEESSSIALGSTHPLTVSGGPRPWILDPANFYKTQETKQSQLQVTFENEKVLFKCGSSEVTEAVRLRIGNLKSSTLPLPIHSEITVSICCAKPTRLEIFDKKQRPSKCPLNVHSMLINTNVELVLRGSGVCNGAATPLASINGLSPKWTTSDSGLLTVNRHGIEADATSGKKEGQVTIQAQAGSLSTKYEITVKKGLNVEPARLVLWNEAVSKGTFTITGGSGHFHVDNLPTSDSPVAIALRARSLTVTPKNNGQVNLRISDACLVGQHADASVRIADIHSLAIDAPQFVEIGQEVEVEILAQDETGASFEKEHRPLADAQLDASNNHVILTKVDGLRYTLRANSIGTVSLSASSKSSSGRVLSSRPHTVQIFSPIFLQPKRLTLIPDSKFQLEVVGGPQPTPPLDFSLNNSMIASIEPNALITSSELGYTAITGTVRVGDGHVTLDTVVLRVASLGGIILSASSRKVETGGRVNLRLRGVIAGAEDEEPFAFGGAIYPFKVTWSVSDPSVLFTTHPLGGDVVEPTDNQFAIWFNAIRGGSVTVKAVVELNEKARKHFTGRTSTFTAETTITVEDGLSLVQPEMDINTVRVAPNSQLKMVTAWSQASFSVPSDFSSRIVISADGHLITNGKEGSAAITVRNVNSPDNETVLIPVTVSRVASLDVHPTIELKSAFENSPLIHLPVGAQIQLNVVPRDARGRRLAAASNSINFRPHRFDLTDIVATNSNQTLTITLKTAGDTVLRIGDASNTHIATFIRLSASESILPRAAHKYANDLVVSDVICLQSNIFTVDGSRWSSQSSSEGRISWLDENLGVAQLTKAGNTFIRLHADKQTIHSKISVVLPSSLRFPDGQKPEFVSNDEHSVFVIPVIAATNNTSGSKVSSIYGECTADQIRSFDAIGAPFECQVAFTRRSKIISAVNWLTVSAVFSPVFGYGCEIRRFDSSVSTSSIVVPEELLKDQFDARITAKWISDGTVQVNDATIDVPFHFAFIVEEKELVFSNMNQIEAALSIWAPTYDSKHIVVSGCEGDIVSVEKTSRSSDKHSAKANVFYNIRLNIKSAALFTEHAKKCQISVENTLTGQVIRVPVTVQLLDETAKQVYNALESRGVVDVLLILAHKYSHAIPTLLWTCLVGIIILVIGIYVKMNVFDKTGSFGDNTLNNTTHQTSMASSLSSTNVSLREPVFRSTPIAGSPQVSLPTARDRLRNQMGSGGDNRLWSY
Protein: BcDNA.GH02431 (Dicarboxylate carrier 1, isoform A) (Dicarboxylate carrier 1, isoform B) (Dicarboxylate carrier 1, isoform C) (Q9Y166)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPHQERKSMWFFGGLASVGAAMVTHPLDLIKVTLQTQQGHLSVAQLIPKLAREQGVLVFYNGLSASVLRQLTYSTARFGVYEAGKKYVNTDSFGGKVALAGASGLVGGIVGTPADMVNVRMQNDVKLPPQQRRNYNNAFDGLVRVYRQEGFKRLFSGATAATARGILMTIGQIAFYDQTKIYLLATPYFQDNLVTHFTASLVAGTIATTLTQPLDVLKTRSMNAKPGEFNGLWDIVKHTAKLGPLGFFKGYVPAFVRLGPHTIITFVFLEQLRLKFGTLN
Protein: Coiled-coil domain-containing protein 12 (Q8WUD4)
Organism: Homo sapiens (Human)
Interaction partners:
- Pre-mRNA-processing factor 17
- Crooked neck-like protein 1
- Pre-mRNA-processing factor 19
- Cell division cycle 5-like protein
- 116 kDa U5 small nuclear ribonucleoprotein component
- Pre-mRNA-splicing factor SYF2
- Peptidyl-prolyl cis-trans isomerase-like 1
- Transcription elongation regulator 1
- Serine/arginine repetitive matrix protein 1
- E3 ubiquitin-protein ligase RNF113A
Sequence:
MEATTAGVGRLEEEALRRKERLKALREKTGRKDKEDGEPKTKHLREEEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAVDAATEQKTCDSD
Protein: Desiccation-related protein PCC27-45 (P22241)
Organism: Craterostigma plantagineum (Blue gem) (Torenia plantagineum)
Interaction partners:
Sequence:
MAQLMNKAKNFVAEKVANVEKPKASVEDVDLKDVGRHGITYLTRICVENPYSASIPVGEIKYTLKSAGRVIVSGNIPDPGSLKGNDKTMLEPAIKVPHSALVSLIKDIGADMDIDYVLELGLVVDLPVIGNFTIPLSHKGEMKLPGLSDIF
Protein: Worniu (Q9VJP2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Achaete-scute complex protein T8
- Protein deadpan
- Miranda, isoform A
- Inscuteable
- LD18634p
- Basic helix-loop-helix neural transcription factor TAP
Sequence:
MDKLKYSRCPLKKRPIMVEESSPEDHLSHDEGPVDLSVASAAVPMEPHWMAKSEPEPQPVPTELRRRFDAAMNQTKEQLARRIWEETREIARAFPDVFTREEIAKSLARLGYGEFELPPEEEVMEPEPEPEQHLPLRYTRDASPTIIKAEPSDEEQFPLRNYNNNLLKSIAEYEDCMKMQNIKEEIPPIPSPQLFYPPPTPLAEPEDLSVTQRRVLSENMNLQNVARALLSMQHMAPQHAPPPIDMEEDQENQDINQLKIKSSNDLYYQCQQCNKCYATYAGLVKHQQTHAYESTEYKIIRSQPGGSGAIVDQTEFCTDQASALIQAANVASAQSMQKPVGVPRYHCQDCGKSYSTYSGLSKHQQFHCPSAEGNQVKKVFSCKNCDKTYVSLGALKMHIRTHTLPCKCPICGKAFSRPWLLQGHIRTHTGEKPFSCQHCNRAFADRSNLRAHMQTHSDVKKYSCPTCTKSFSRMSLLAKHLQSGCQTEQSGGPSGSGGGFDQQQLQQHLQVYEEGHNPHQLYYAGSVGSSNGEEEEGGEYQMQPPAIY
Protein: Cytosol aminopeptidase (EC 3.4.11.1) (Aminopeptidase A/I) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase) (P68767)
Organism: Escherichia coli (strain K12)
Function: Probably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Required for plasmid ColE1 site-specific recombination but not in its aminopeptidase activity. Could act as a structural component of the putative nucleoprotein complex in which the Xer recombination reaction takes place.
Interaction partners:
- Aminopeptidase N
- Cytosol non-specific dipeptidase
- Peptidase B
- Glutathione hydrolase proenzyme
- Glutathione synthetase
- Glutamate--cysteine ligase
- Putative glutamate--cysteine ligase 2
- Glutathione-specific gamma-glutamylcyclotransferase
- Aspartate aminotransferase
- Serine hydroxymethyltransferase
Sequence:
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMKELGMHSYLAVGQGSQNESLMSVIEYKGNASEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMANHNPLAHELIAASEQSGDRAWRLPLGDEYQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLAQFLLNRAGFNGEE
Protein: Microsomal triglyceride transfer protein large subunit (P55156)
Organism: Bos taurus (Bovine)
Function: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:P55157}. Golgi apparatus {ECO:0000250|UniProtKB:P55157}. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum. {ECO:0000250|UniProtKB:P55157}.
Interaction partners:
- Apolipoprotein B
- Protein disulfide-isomerase
- Apolipoprotein C-III
- Fatty acid-binding protein, liver
- Apolipoprotein A-I
- Apolipoprotein E
- Diacylglycerol O-acyltransferase 1
- ATP binding cassette subfamily G member 5
- NPC1 like intracellular cholesterol transporter 1.
- Apolipoprotein A-II
Sequence:
FLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVFLDRGKGNLQDSVGYRISSNVDVALLWRSPDGDDNQLIQITMKDVNLENVNQQRGEKSIFKGKKSSQIIRKENLEAMQRPVLLHLIHGKIKEFYSYQNEPAAIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCKIERAGFTTPHQVLGVTSKATSVTTYKIEDSFVVAVLSEEIRALRLNFLQSIAGKIVSRQKLELKTTEASVRLKPGKQVAAIIKAVDSKYTAIPIVGQVFQSKCKGCPSLSEHWQSIRKHLQPDNLSKAEAVRSFLAFIKHLRTAKKEEILQILKAENKEVLPQLVDAVTSAQTPDSLDAILDFLDFKSTESVILQERFLYACAFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNQGCKLKGVIEAKKLILGGLEKAEKKEDIVMYLLALKNARLPEGIPLLLKYTETGEGPISHLAATTLQRYDVPFITDEVKKTMNRIYHQNRKIHEKTVRTTAAAIILKNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFETPASKMVRQVLKEMVAHNYDRFSKSGSSSAYTGYVERTSHSASTYSLDILYSGSGILRRSNLNIFQYIEKTPLHGIQVVIEAQGLEALIAATPDEGEENLDSYAGLSALLFDVQLRPVTFFNGYSDLMSKMLSASSDPMSVVKGLLLLIDHSQELQLQSGLKANMDVQGGLAIDITGAMEFSLWYRESKTRVKNRVSVLITGGITVDSSFVKAGLEIGAETEAGLEFISTVQFSQYPFLVCLQMDKEDVPYRQFETKYERLSTGRGYISRKRKESLIGGCEFPLHQENSDMCKVVFAPQPESSSSGWF
Protein: Bifunctional lycopene cyclase/phytoene synthase [Includes: Lycopene beta-cyclase (EC 5.5.1.19); Phytoene synthase (EC 2.5.1.32)] (Q9UUQ6)
Organism: Mucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
Function: Bifunctional enzyme that catalyzes the reactions from prephytoene diphosphate to phytoene and lycopene to beta-carotene via the intermediate gamma-carotene.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLLTYMEVHLYYTLPVLGVLSWLSRPYYTATDALKFKFLTLVAFTTASAWDNYIVYHKAWSYCPTCVTAVIGYVPLEEYMFFIIMTLLTVAFTNLVMRWHLHSFFIRPETPVMQSVLVRLVPITALLITAYKAWHLAVPGKPLFYGSCILWYACPVLALLWFGAGEYMMRRPLAVLVSIALPTLFLCWVDVVAIGAGTWDISLATSTGKFVVPHLPVEEFMFFALINTVLVFGTCAIDRTMAILHLFKNKSPYQRPYQHSKSFLHQILEMTWAFCLPDQVLHSDTFHDLSVSWDILRKASKSFYTASAVFPGDVRQELGVLYAFCRATDDLCDNEQVPVQTRKEQLILTHQFVSDLFGQKTSAPTAIDWDFYNDQLPASCISAFKSFTRLRHVLEAGAIKELLDGYKWDLERRSIRDQEDLRYYSACVASSVGEMCTRIILAHADKPASRQQTQWIIQRAREMGLVLQYTNIARDIVTDSEELGRCYLPQDWLTEKEVALIQGGLAREIGEERLLSLSHRLIYQADELMVVANKGIDKLPSHCQGGVRAACNVYASIGTKLKSYKHHYPSRAHVGNSKRVEIALLSVYNLYTAPIATSSTTHCRQGKMRNLNTI
Protein: Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit] (P28039)
Organism: Homo sapiens (Human)
Function: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:8089145, ECO:0000305|PubMed:1883828}. Cytoplasmic vesicle {ECO:0000269|PubMed:8089145}. Note=Detected in urine. {ECO:0000250|UniProtKB:O35298}.
Interaction partners:
Sequence:
MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVGCVLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSGSDICSLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQLSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSRNKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSHLPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQVSPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAFHEIIQEWQKRGGQPWQLIEPVDGFHPNEVALLLLADHFWKKVQLQWPQILGKENPFNPQIKQVFGDQGGH
Protein: Probable calcium-binding protein CML13 (Calmodulin-like protein 13) (Q94AZ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- Probable calcium-binding protein CML36
- Probable calcium-binding protein CML34
- Calcium-binding protein CML39
- Probable calcium-binding protein CML33
- Probable calcium-binding protein CML35
- Probable calcium-binding protein CML32
- Probable calcium-binding protein CML21
- Probable calcium-binding protein CML49
- Probable calcium-binding protein CML43
- Probable calcium-binding protein CML28
Sequence:
MGKDGLSDDQVSSMKEAFMLFDTDGDGKIAPSELGILMRSLGGNPTQAQLKSIIASENLSSPFDFNRFLDLMAKHLKTEPFDRQLRDAFKVLDKEGTGFVAVADLRHILTSIGEKLEPNEFDEWIKEVDVGSDGKIRYEDFIARMVAK
Protein: Pyridoxal-dependent decarboxylase domain-containing protein 1 (H3BND4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MACSILEGCRREVRRETWKPGPGSEIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVSILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSDTTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPGPWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGRERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVACIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPEGENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIEENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKGRTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSETSSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQVEGPESLR
Protein: 60S ribosomal protein L23a (Q57ZH2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- 60S ribosomal protein L17, putative
- 60S ribosomal protein L35, putative
- Ribosomal protein
- 60S ribosomal protein L5, putative
- 60S ribosomal protein L19, putative
- 60S ribosomal subunit protein L31, putative
- Ribosomal protein L37
- 60S ribosomal protein L35A, putative
- 60S ribosomal protein L27a
Sequence:
MPAKAASAAASKKNSAPKSAVSKKVAKKGAPAAAAKPTKVVKVTKRKAYTRPQFRRPHTYRRPATVKPSSNVSAIKNKWDAFRIIRYPLTTDKAMKKIEENNTLTFIVDSRANKTEIKKAIRKLYQVKTVKVNTLIRPDGLKKAYIRLSASYDALDTANKMGLV
Protein: Collagen alpha-1(XXVII) chain A (C7DZK3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play a role during the calcification of cartilage and the transition of cartilage to bone (By similarity). Together with col27a1b, plays a role in development of the notochord and axial skeleton.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q5QNQ9, ECO:0000255|PROSITE-ProRule:PRU00793}.
Interaction partners:
Sequence:
MNLATRRRVRRTSRLVAKRALLLCILLYCTSFGFTQVLFEDVDVLQRLALRAELGSRAVPAGVISLRSGVILTTRARVTTPTRSLFPPELFWNCTIILSVRSHRLNSAFLFSVLSGNRIQLGLEISPGKLTLHAGPGNAATFLYNLHDGRWHHLAFVINGRSVTLHSPCSESDSGVTQELPVLPERLNPRGTFRLGGSSALLPGVVPFEGAVCQFDVVPSAQAQQNICSAIRRQCRENDTYRPAPPALLPLPSRHAPPLLAHTLPPNRTFTFTPTNFLLAPVNGAGGSSSVRMSDGVRPKPSSTTPPPLALMQTGIDAPLSLSLVTHKPSLRTPKPTASKPGVWLTPTKPARPKPTPGKASPKLNVSKSFGPKPTARLAASKLGSKAIGPKPTPLKPSKPVKKPTSVPKPNPTKNASIGPRPTNSNKKQNAILKPLPAPKPTVPKRPSPTNKKPLQPKNKSHTTPLTPKSTLAPNSTSKKPLPTLKSTSFTTAAPNKPPKTLETPKVNPDKSKTPVPYSTPRTPRFSIQSVTLPAFDDFQSFEVEPTRFSLLVGAPGLKGDQGESGLPGPPGKPGQPGMRGPRGPPGPHGKPGRPGPTGLKGKKGDPGLSPGKAPKGDKGDVGLPGPVGLVGVEGRKGQKGHPGPPGLPGEPGEQGPVGEAGAKGYPGRQGLPGPIGPVGPKGARGFIGIPGLFGLPGADGERGSPGPPGKRGKMGRPGFPGDFGERGPPGLDGEPGVIGAPGPPGVLGLIGDMGPAGTVGVPGLNGLKGVPGNMGESGLKGDKGDVGLPGEQGEIGFQGDKGVQGLPGLPGPRGKPGPQGKTGEIGPSGLPGPPGPEGFPGDIGKPGLNGPEGPKGKPGARGLPGPRGAAGREGDEGPLGPPGPFGLEGQMGSKGFPGALGLEGVKGEQGVTGKAGPMGERGLVGFIGPGGEAGLAGEKGDRGEMGLPGPPGEKGSTGHPGTPGEGGPPGPPGSPGSPGSRGPIGIRGPKGRRGPRGPDGVPGEIGTEGKKGPDGPPGKIGFPGHAGKIGESGEVGPKGFPGIQGPSGATGDKGIAGEPGPSGPPGTLGPQGNPGPKGPAGKVGDSGLPGEPGEKGSIGLAGNAGAAGLIGARGEPGLEGEAGPAGPDGTKGEKGDMGTEGEQGVRGDPGIKGKDGPPGDPGLTGVRGPEGKSGKSGERGKPGLKGAKGNIGHLGETGSVGKIGPIGTTGPKGSRGTIGHAGAPGRMGLQGDPGISGYEGHKGPQGPIGPPGPKGAKGEQGDDGKVEGPTGAPGLRGPVGKRGDRGEPGDPGYVGQQGVDGLRGKPGAPGLPGDPGPRGTQGPKGSKGEQGQKGKQGQQGERGSRGSPGVVGLPGPRGTVGREGREGFPGTDGLAGKDGSRGTPGDQGDDGEFGLPGKPGAPGKVGVIGLPGPQGSFGPKGERGLPGHPGPSGKRGFKGGMGLPGPQGDRGSKGQPGDIGEPGFPGMLGMFGPKGPPGDFGPKGIQGPKGPQGNMGRGGLAGPVGVIGPIGNPGSRGDTGNKGELGVQGPRGAPGPRGPPGLPGPPGIPLAMNQDFGLGVVQPVFRETHTQKIEGRGLLDMPMLDQAPEILRTLDYLSSLVHSLKNPLGTRDHPARLCRDLHDCRDTLYDGTYWIDPNLGCSSDSIEVMCNFSSGGRTCLRPITTAKLEFSVGRVQMNFLHLLSAGAEQRITIHCLNVTIWSHAPNQPPSQNAVQFHSWIGEVLEPDVLEDTCWQLNGRWQHADFLFRVLDPALLPVVRISNLPKVMPSSRFHLEVGPVCFL
Protein: RNA-binding protein 24 (RNA-binding motif protein 24) (D3Z4I3)
Organism: Mus musculus (Mouse)
Function: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability. Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities. Involved in myogenic differentiation by regulating MYOG levels. Binds to multiple regions in the mRNA 3'-UTR of TP63, hence inducing its destabilization. Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence. Plays a role in the regulation of mRNA translation. Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation. Binds to a huge amount of mRNAs (By similarity). Required for embryonic heart development, sarcomer and M-band formation in striated muscles. Together with RBM20, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6GQD3}. Cytoplasm {ECO:0000269|PubMed:25217815}.
Interaction partners:
- RNA binding protein fox-1 homolog 1
- RNA binding protein fox-1 homolog 2
- RNA-binding protein 20
Sequence:
MHTTQKDTTYTKIFVGGLPYHTTDASLRKYFEVFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFGVQQLHPALIQRPFGIPAHYVYPQAFVQPGVVIPHVQPTAAAASTTPYIDYTGAAYAQYSAAAAAAAAAAAYDQYPYAASPAAAGYVTTGGYSYAVQQPITAAAPGTAAAAAAAAAAAAAFGQYQPQQLQTDRMQ
Protein: Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291) (Q6ZMG9)
Organism: Homo sapiens (Human)
Function: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8C172}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8C172}.
Interaction partners:
- Sphingolipid delta
- 3-ketodihydrosphingosine reductase
- Acid ceramidase
- Ceramide glucosyltransferase
- Ceramide kinase
- Sphingomyelin phosphodiesterase 2
- Sphingolipid delta
- Sphingomyelin phosphodiesterase
- Sphingosine kinase 1
- Alkaline ceramidase 2
Sequence:
MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
Protein: Transcription factor Sox-21-B (SRY-box containing gene 21b) (Q6RVD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a negative regulator of transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- SRY-box transcription factor 4a.
Sequence:
MSKPMDHVKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLMKKDKFAFPVAYNLGEHEALKVGGLPAGALTESLMSNPDKAAAAAAAAAARVFFNPSMSANPYSFFDLGSKMTELSPPSFSYASPLGYPTAATAFSGAVGGGAHTHTHSHPSPGNPGYMIPCNCAAWPSAGLQPPLAYILLPGMGKPQLEPYPAYAAAL
Protein: Tribbles homolog 1 (Tribbles pseudokinase 1) (A0A2R8QE16)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Novel protein similar to vertebrate ring finger and WD repeat domain 2
Sequence:
MSVQWIHNPVTLPGRHGHKRFDTDEPVSRCPRLSESSADAGLLGSSPGSPVSGAPLSVTSAHQGPARIGQFLLVPLTDRPGVQSALDMDTGEELLCKVFDMGQYQEKIRAYSMLSNHKNIAQIKDIVLGESKAYVFQEKDFGDMHTFVKSSKRLSEDLASKLFYQVVSAVNHCHQVGIVLGDLKLRKFVFTDEKRTHLKLEGLEYCHVLCGEDDSMFDTHGCPAYVSPEILNGGGCYSGKQADVWSLGVMLYTMLVGRYPFHDADPATLFSKIRRGTYCLPDGLSLTARCLLRSLLRKDPGERLTAAEVLIHPWFNSNIQDSRNPEQEVNLREQTVPQIEMEQDEDLFS
Protein: MAP7 domain-containing protein 3 (Q8IWC1)
Organism: Homo sapiens (Human)
Function: Promotes the assembly and stability of microtubules.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15561729}. Note=Localizes to the microtubules throughout mitosis. {ECO:0000269|PubMed:22142902}.
Interaction partners:
Sequence:
MMADGAAAGAGGSPSLRELRARMVAAANEIAKERRKQDVVNRVATHSSNIRSTFKPVIDGSMLKNDIKQRLARERREEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKERKEKEEQRRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLADDYQQKRWSWGGSAMANSESKTANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVAKRKTDKERSSSLNRRDSNLHSSTDKEQAERKPRVTGVTNYVMQYVTVPLRKCTSDELRAVMFPMSTMKIPPQTKVEESPLEKVETPPKASVDAPPQVNVEVFCNTSMEASPKAGVGMAPEVSTDSFPVVSVDVSPVVSTYDSEMSMDASPELSIEALPKVDLETVPKVSIVASPEASLEAPPEVSLEALPEVSVEAAPEGSLEAPPKGSAEVAPKESVKGSPKESMEASPEAMVKASPKTSLEASMEASPKAKARDAPKKSEMDKQALIPIAKKRLSSYTECYKWSSSPENACGLPSPISTNRQIQKNCPPSPLPLISKQSPQTSFPYKIMPIQHTLSVQSASSTVKKKKETVSKTTNRCEALSQRHMIYEESGNKSTAGIMNAEAATKILTELRRLAREQREKEEEERQREEMQQRVIKKSKDMAKEAVGGQAEDHLKLKDGQQQNETKKKKGWLDQEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQERLERKKRIEEIMKRTRKTDVNASKVTETSSHDIYEEAEADNEESDKDSLNEMFPSAILNGTGSPTKFKMPFNNAKKMTHKLVFLEDGTSQVRKEPKTYFNGDLKNFRQKSMKDTSIQEVVSRPSSKRMTSHTTKTRKADETNTTSRSSAQTKSEGFHDILPKSSDTFRQ
Protein: Uncharacterized ABC transporter permease YknZ (O31712)
Organism: Bacillus subtilis (strain 168)
Function: Part of an unusual four-component transporter, which is required for protection against the killing factor SdpC (sporulation-delaying protein).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20713508, ECO:0000269|PubMed:22707703, ECO:0000269|PubMed:22882210}; Multi-pass membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:20713508, ECO:0000269|PubMed:22882210}; Multi-pass membrane protein {ECO:0000255}. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion. {ECO:0000269|PubMed:20713508, ECO:0000269|PubMed:22882210}.
Interaction partners:
- Uncharacterized ABC transporter ATP-binding protein YknY
- Putative efflux system component YknX
- Uncharacterized ABC transporter ATP-binding protein YvrO
- ABC transporter ATP-binding protein YtrE
- Uncharacterized ABC transporter ATP-binding protein YvcR
- ABC transporter ATP-binding protein YxdL
- Bacitracin export ATP-binding protein BceA
- Uncharacterized ABC transporter ATP-binding protein YclH
- Cell division ATP-binding protein FtsE
- Putative efflux system protein YvrP
Sequence:
MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQGGEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVASTSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKMAKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDFSNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIGSIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGGLVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIEALRYE
Protein: LP03547p (Spliceosome-ribosome linker protein) (Q9VG69)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Enoyl-CoA delta isomerase 1, mitochondrial
- Enoyl-CoA delta isomerase 1, mitochondrial
- Enoyl-CoA delta isomerase 1, mitochondrial
- HL08109p)
- acetyl-CoA C-acyltransferase
Sequence:
MLRKFGGLLAQQVGQQARFTAASRTFSSTKALHKDPATQEAEAAPPKNILVEKDKNITLIGINRPQQRNAIDSLTASQLCDAFANFEADDTSPVAVLYGVGGSFCSGFDILEISTDEKEEISVDILMRPEGSVGPTRRQIKKPVVCGINGYCIANGLELALMCDLRVMEESAVLGFFNRRFGVPMLDAGTIRLPAMIGLSRALDLILTGRPVGSQEAHDIGLVNRIVPTGTALGNALELATCLAKFPQRALIHDRNSVYSSTFETSTFHQAVQNEVMFTSREIIEDMQNGIKWFNQTFKPDTTHSWLKRDRSMADWDDEEVAEAAAQKEKLKQEQEAALAEAEKQKQAEKAQKRSKKTEESAAESVDSKDPKDKPNEK