wanglab/gogpt-training-data huggingface dataset:
Protein: FCS-Like Zinc finger 18 (P0DO12)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:29945970}. Nucleus {ECO:0000269|PubMed:29945970}.
Interaction partners:
- FCS-Like Zinc finger 17
Sequence:
MTKISVGLQLVTRDSREKLNNIVIKSSLRLNRSNPNISELCFLKTCHLCNKQLHQDKDVYMYRGDLGFCSRECRESQMLIDDRKELEASTKMMLASYRRCNNGAGKSESRNLFDDLRRRRQLFIVP
Protein: AT1G21350 protein (F24J8.1 protein) (Thioredoxin superfamily protein) (Q9LPL8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAASTVVTTVTHGASSILPSRTALAVSSRRFSSFSPSRLDFSNLRRRVNAPSPRRLVVRAARTESAGVKLGARAPNFELPEPLTGNLWKLEDFELYPSLLVMFICNHCPFVIHLKKDIVKLCNFYMKKGLAVVAISSNSVVTHPQDGPEFMAEDAKVFKYPFPYLYDESQEVAREFGAVCTPEFFLYKKDGRRPFELVYHGQFDDSRPSSNSPVTGRDLSLAIDLSLSCQPIPSNQKPSVGCSIKWHPETKS
Protein: Synaptotagmin-like protein 3 (Exophilin-6) (Q4VX76)
Organism: Homo sapiens (Human)
Function: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).
Subcellular location: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Ras-related protein Rab-27A
- Ras-related protein Rab-27B
Sequence:
MAQEIDLSALKELEREAILQVLYRDQAVQNTEEERTRKLKTHLQHLRWKGAKNTDWEHKEKCCARCQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKTGEWFYEERAKKFPTGGKHETVGGQLLQSYQKLSKISVVPPTPPPVSESQCSRSPGRLQEFGQFRGFNKSVENLFLSLATHVKKLSKSQNDMTSEKHLLATGPRQCVGQTERRSQSDTAVNVTTRKVSAPDILKPLNQEDPKCSTNPILKQQNLPSSPAPSTIFSGGFRHGSLISIDSTCTEMGNFDNANVTGEIEFAIHYCFKTHSLEICIKACKNLAYGEEKKKKCNPYVKTYLLPDRSSQGKRKTGVQRNTVDPTFQETLKYQVAPAQLVTRQLQVSVWHLGTLARRVFLGEVIIPLATWDFEDSTTQSFRWHPLRAKAEKYEDSVPQSNGELTVRAKLVLPSRPRKLQEAQEGTDQPSLHGQLCLVVLGAKNLPVRPDGTLNSFVKGCLTLPDQQKLRLKSPVLRKQACPQWKHSFVFSGVTPAQLRQSSLELTVWDQALFGMNDRLLGGTRLGSKGDTAVGGDACSLSKLQWQKVLSSPNLWTDMTLVLH
Protein: Transmembrane protein 216 (Q9P0N5)
Organism: Homo sapiens (Human)
Function: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22282472}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Interaction partners:
- Meckelin
- Coiled-coil and C2 domain-containing protein 2A
- Tectonic-1
- B9 domain-containing protein 1
- B9 domain-containing protein 2
- Centrosomal protein of 290 kDa
- Tectonic-3
- Tectonic-like complex member MKS1
- Transmembrane protein 231
- Jouberin
Sequence:
MLPRGLKMAPRGKRLSSTPLEILFFLNGWYNATYFLLELFIFLYKGVLLPYPTANLVLDVVMLLLYLGIEVIRLFFGTKGNLCQRKMPLSISVALTFPSAMMASYYLLLQTYVLRLEAIMNGILLFFCGSELLLEVLTLAAFSRI
Protein: sphingomyelin phosphodiesterase (EC 3.1.4.12) (F1QUD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Sphingomyelin phosphodiesterase 4
- Sphingomyelin phosphodiesterase 3
- Ceramide synthase 5.
- Sphingomyelin phosphodiesterase
- Ceramide kinase
- Ceramide synthase 6
- Ceramide kinase family protein
- Sphingomyelin phosphodiesterase 5
- UDP-glucose ceramide glucosyltransferase.
- sphingolipid 4-desaturase
Sequence:
MAPQQPGNLRVFSLNCWGIRFLSKLCAQRYEMIGELLGREQHDIALLQEVWSERDFLFLKRKLSCSHPYTHYFKSGVIGSGLAVFSKHRIQDALLYQYSLNGYPYMLSHGDWFGGKAAGLVIVEVFGLKAHVYVTHLHAEYSRAQDGYLPHRIVQSWELQQFVRHTSHGADLVILGGDLNMHPQDLGNRLLRSHTGLRDCYTETDKFDGCEDGHTLIANNHFTKKQDLIPFEKGIRIDYILIKGSQRVSVKCESLSTTKGSVSDKPFPYSDHEALMADLNLLSSQDCTDAPPASDQMDVVSEARAVVKEGLGKTEALRDRSLHLMFAGLLLLLLVLCSSSFFSFSAAGFLGAVCVFILLSGALLYMLFTTHIKVLKETEDQMMLRSQNLQTKLTGCRVSGSSSSFHASPEIQPSSPFKREE
Protein: 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) (P31947)
Organism: Homo sapiens (Human)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:37797010}. Nucleus {ECO:0000250|UniProtKB:O70456}. Secreted {ECO:0000305|PubMed:8515476}. Note=May be secreted by a non-classical secretory pathway. {ECO:0000305|PubMed:8515476}.
Interaction partners:
- Cellular tumor antigen p53
- E3 ubiquitin-protein ligase Mdm2
- Estrogen receptor
- Forkhead box protein O1
- Protein Mdm4
- Leucine-rich repeat serine/threonine-protein kinase 2
- Keratin, type I cytoskeletal 17
- M-phase inducer phosphatase 3
- G2/mitotic-specific cyclin-B1
- Cyclin-dependent kinase 1
Sequence:
MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGGEAPQEPQS
Protein: Multiphosphoryl transfer protein (MTP) (Diphosphoryl transfer protein) (DTP) (Phosphotransferase FPr protein) (Pseudo-HPr) [Includes: Phosphocarrier protein HPr (Protein H); PTS system fructose-specific EIIA component (EIIA-Fru) (EIII-Fru) (Fructose-specific phosphotransferase enzyme IIA component)] (P69811)
Organism: Escherichia coli (strain K12)
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- PTS system fructose-specific EIIB'BC component
- Phosphoenolpyruvate-protein phosphotransferase
- 1-phosphofructokinase
- Multiphosphoryl transfer protein 1
- Multiphosphoryl transfer protein 2
- PTS system mannitol-specific cryptic EIICB component
- Phosphoenolpyruvate-dependent phosphotransferase system
- Phosphocarrier protein HPr
- PTS system 2-O-alpha-mannosyl-D-glycerate-specific EIIABC component
- Catabolite repressor/activator
Sequence:
MFQLSVQDIHPGEKAGDKEEAIRQVAAALVQAGNVAEGYVNGMLAREQQTSTFLGNGIAIPHGTTDTRDQVLKTGVQVFQFPEGVTWGDGQVAYVAIGIAASSDEHLGLLRQLTHVLSDDSVAEQLKSATTAEELRALLMGEKQSEQLKLDNEMLTLDIVASDLLTLQALNAARLKEAGAVDATFVTKAINEQPLNLGQGIWLSDSAEGNLRSAIAVSRAANAFDVDGETAAMLVSVAMNDDQPIAVLKRLADLLLDNKADRLLKADAATLLALLTSDDAPTDDVLSAEFVVRNEHGLHARPGTMLVNTIKQFNSDITVTNLDGTGKPANGRSLMKVVALGVKKGHRLRFTAQGADAEQALKAIGDAIAAGLGEGA
Protein: Putative reductase 1 (EC 1.1.1.-) (Q12458)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm.
Interaction partners:
- Glycerol 2-dehydrogenase
- NADP-dependent 3-hydroxy acid dehydrogenase
- Dihydroxyacetone kinase 1
Sequence:
MPATLKNSSATLKLNTGASIPVLGFGTWRSVDNNGYHSVIAALKAGYRHIDAAAIYLNEEEVGRAIKDSGVPREEIFITTKLWGTEQRDPEAALNKSLKRLGLDYVDLYLMHWPVPLKTDRVTDGNVLCIPTLEDGTVDIDTKEWNFIKTWELMQELPKTGKTKAVGVSNFSINNIKELLESPNNKVVPATNQIEIHPLLPQDELIAFCKEKGIVVEAYSPFGSANAPLLKEQAIIDMAKKHGVEPAQLIISWSIQRGYVVLAKSVNPERIVSNFKIFTLPEDDFKTISNLSKVHGTKRVVDMKWGSFPIFQ
Protein: Unconventional myosin-VI (Unconventional myosin-6) (E9QFU5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane, clathrin-coated pit {ECO:0000256|ARBA:ARBA00004600}.
Interaction partners:
Sequence:
MDDGKPVWAPHPTDGFQLGMIVDIGADALTIEPLHQRGKTFLAPISQVFPAEDDVNKHVEDNCSLMYLNEATLLNNIRIRYSKDMIYTFVANILIAVNPYFDIPKLYSPESIKSYQGRSLGTLPPHVYAIADKAYRDMRVLKMSQSIIVSGESGAGKTENTKFVLRYLTTSYGTGQDIDERIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICMQSQEERNYHIFYRLCAGASEDIRNMLHLNSPDSFRYLNRGCTRYFANKDSDKQIMQNRKSPEHGKVGALKDPLLDDLGDFNRMVVAMKKIGLDDTEKLNLFRVVAGVLHLGNIDFEETGSTSGGCILKNQSSQTLEYCADLLGLDQDDLRVSLTTRVMLTTAGGAKGTVIKVPLKVEQANNARDALAKAVYSRLFDHVVKRVNQCFPFDTSSNFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQREGLGVNEVHYVDNQDCIDLVEAKLVGVLDILDEENRLPQPSDQHFAEAVHSKHKDHFRLTVPRKSKLTIHRNLRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLVCESKDKFVRDLFENNSNSKDSKQKAGKLSFISVGNKFKTQLNLLLEKLRSTGSSFIRCVKPNLKMVSHQFEGAQILSQLQCSGMVSVLDLMQGGFPSRAPFHELYNMYKQYMPNKLTRLDPRLFCKALFKALGLNENDYKFGLTRVFFRPGKFAEFDQIMKSDPDHLAELVKRVNKWLVCSRWKKVQWCTLSVIKLRNKMSYRASACIRIQKTVRMWLCRRRHKPRVDGLVKVKNLRKRMERFNEAVNGLKEGKAEMSKQIEELAASTDALMAKIKTTVMSRKEIEQEYEGLVKRSEQLLSSMQKKKQEQEETERLKHIQEEMEKERKRHEEEEQLRKQEEEDRRMKSEMEQKRKQEEEERKKREEEERVLQAELEMQLALDREEETQRQTILEQERRDRELAMRIAQNEAELIQDEAQMDPILRRGAQVQANKVAAGVKKYDLSKWKYAELRDAINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTDTEMRAPKSVTDYAQQNPAPPVPARQQEIAMNRQQRYFRIPFIRPADQYKDPQNKKKGWWYAHFDGPWIARQMELHPDKQPILLVAGKDDMEMCELSLEETGLTRKRGAEILPRQFEEIWERCGGIQYLKNAIESKQARPTYATAMLQNLLK
Protein: Elongation factor 1-alpha (Q9DDK2)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
- Elongation factor 1-gamma
- Valine--tRNA ligase
- Valine--tRNA ligase
- Elongation factor 1-beta
- Elongation factor 1-beta
- GTP-binding nuclear protein Ran
- Small ribosomal subunit protein uS10
- 40S ribosomal protein S15
- 60S ribosomal protein L4-A
- Methionine--tRNA ligase, cytoplasmic
Sequence:
MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETGRYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAGGVGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSQKRFEEIQKEVSTYIKKIGYNPATVAFVPISGWHGDNMLEASANMGWFKGWKVERKDGNANGVTLLEALDSILPPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGTLKAGMIVTFAPANVTTEVKSVEMHHETLESAMPGDNVGFNVKNVSVKDIRRGNVAGDSKNDPPMEAGTFTAQVIILNHPGQISQGYAPVLDCHTAHIACKFSELKEKIDRRSGKKLEDAPKFLKSGDAAIVDMIPGKPMCVESFQEYPPLGRFAVRDMRQTVAVGVIKAVDKKAASSGKVTKSAVKAGKK
Protein: Probable serine/threonine-protein kinase pdkA (EC 2.7.11.1) (3-phosphoinositide-dependent protein kinase A) (Pdk-class protein kinase A) (Q54TW2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Probable serine/threonine-protein kinase DDB_G0288795
- RAC family serine/threonine-protein kinase homolog
Sequence:
MENIVITNTSGGGGGGVPSSSTDPPNNTTTTTATASAIDLNMSLSPFLSSPSLSSPSIQSAKKKTIEDFIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEYVSPELISNKETSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRELVYPINMNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPFFQDFNWSSLSNMSHPPPPIQPPQEKIIFDGDELFSPSLDCTTPRNNNVDENHQQNSCNNNNNNNNNINNINNNNNSSSNNISNSNSNSNSSNNLNISNGNLSTPRSSSSSSSQQPTQRSGSSGGSRDGGSSSNNISKWLNNGENVIYQGLVWKRKGFSIKKRQLILTDTPRLIYIDPKKMELKGEIPWSDSIKPKLKSNNNFVIKTPKRKYLLEDVAHNPQKWVDSIKSVILSSGSSN
Protein: Potassium channel K1 (PfK1) (PfKch1) (Q8I5E6)
Organism: Plasmodium falciparum (isolate 3D7)
Subcellular location: Membrane {ECO:0000269|PubMed:32957994}; Multi-pass membrane protein {ECO:0000255}. Host cell membrane {ECO:0000269|PubMed:18218136}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the membrane of infected red blood cells. {ECO:0000269|PubMed:18218136}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit
- cGMP-dependent protein kinase
Sequence:
MNNDNIGREPIDVVYDKRFSSRIKPKTKKKKRNENRMRLVRIQHYIYNIFTSFLCLFIVILILYASIDISINYGPVIILYILILELGSMLISYILLQFPFFYRKLKNTFMRARNINKYSHQYRPLYYDNNSFTDENESFNISDDEKKEKRKRKHTYSFMSSDGGRKRSNFRRFLSSYKSKKGNEFVNSKTMKNKTKKNTRRKGFLSFNWIGYKNGETNKNRNDNIVNDVYKKYNDDNKYNDDNKYNDDNYNDDDNKYNDDDILNSHSEQDQRKKKKKKKEKRIVVFPRNDTGGNSFKRESIYIDDCNMWMKKTMRKSNRPNFKLTRSLSFNINMNKDDDLMMKDSASLDNIQIFLGHRSSKFLREKNKLQKRKTSIYNKYVPLTFASSYKDDFFKEILKSQTDGIISSSSDYSSSSEDSNKNVYKTIYINNNNNNVDKKGKIDEEDNIVVRNNIHSNENIIIKENPYSLRNAILFHKEKRKYRKNINTLSDDDNKNFAFHSGKKKIKRKEKKRRCFIKLKCFNKIKNLYRFFINYNMKSSKSSNNLYLFFRGFYIYTKHRFVHYLSYEPIWIVAILIRIVLWCIVWIWAASYMERKPKNFEITEWNMKNVPSFYGYIECTFQWCGVFDYFFGLYFSNNKLKYIFSFFSLIDFITTPVSSLIMNFFVQDNINHNYWFLILGPLRFLRLVRAESTISSCFFWLNDVKIIIIGIIILALAILFTFSGIMYILEAPDIERDFVKPLDFVYFGVITMSTVGYGDYTPVTKAGKFLTMFIIITCISFVAAQFKRLKEAMFSPKTVMGIIPKQDDDYILILGPVSPTQLLYICKGINNSFPNSVESIFLFTPLPVVIYRYVYGSIVKNTNIKICISGGNECFICPSIIYDAVINSRALYILNNVDSEKYTLMYQQIFLASNNINFNNHDHQNQRISSDDILHNNIINKYSKDKTKNWKYSDLFSEYKNEINKNNMLNLEMNININNSYSIKEKDDQECLLRFIGTYNICNSLIPITLQLSNNTYEELIKSMNVYNYISIEELKYALLAKSVNCKGLFFLIINFFYKPKAVKSLKKYIIDLKLLMYNGMLRRKNRERLSSSNLKIKQPSQQKSRKGNLINKISLFFKKGQNHQLDAEGISHDEKNNSNTSRTRGNNRNDHMDPQIKGKGVFEMNQKEQKQVMLKEGMNKNMNKNIIKDMEKNMNSNGKDNINDSINESIEKNDLFFLNSLDPNDDRNIHNLSYKNYYYMLEKVNLNMYYYLEGLKYNIYRFQFPECMRGFLFQTASEYLYQKYSAFLIGIITINKEIFLNPVNYIIGEENKYFYTSAFSGIILTTSLDSLIKLSSINNISKKVYEYNKRLIEEKYKSTFSKSWINSDDDHHNSDHKNFVTNTQIKETQIDGDEVKIVLTSHDDSLHPSDRSVKNRKNSMKSIYNQKKSNLGDQKKKNRNQDDRTEHQVDDNNDSDYLQIESVPKKKRNMYYSLVLGICELENYISAYKDAFVDKDKPLLLVCGWPDNIHMFFKYLKRNVYNSSYRNKNNSNIHTYDNNNNNNNNNNIYSKTVKNKKGKRKKMKKLNDDIKYNIIILSLHVPKFNYENDLFNYSENVVFIRGSPLNSYNLIQAGVFYAKRIIILNSNHSLFIDKDAYRIDNEVIIIKNIVNQLFNYISKNKENYFNLLRKTFPKEYIDITINERIFLNDNINNSPNINEMIKGKMSDSSYDSLDDNYSSDDDSSSSNYDDDDEDNDNDEDNVDNNNDHGGESLLLKKKRKKKNMIKLKKRALNVNNIFNINKNPYLICLIKNSESLEYIDGSINLSYENYNDNEKMNKIWENCGEYIYTFELVSANIFVHEMLHNLVSFSLPISKYAIEYSVIYSLIGIDINEYSKNAQKFHKNLNLSTGYVNLVPIPSYFYKKSFYKCFSYFLHNKLSLCIGILRYIDISSLSNKSKKIFVLSCPSRTMKIEPHDQAYVIAHRM
Protein: Protein Pat (Primordial germ cell-associated transcript protein) (Xpat) (O73622)
Organism: Xenopus laevis (African clawed frog)
Function: Probably plays a role in germ plasm formation, positioning and maintenance.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16216237, ECO:0000269|PubMed:18068700}. Nucleus {ECO:0000269|PubMed:16216237}. Note=Unlike the transcript, the protein is not exclusively localized to germ plasm but is also present in the nuclei of early oocytes, of later stage primordial germ cells (PGCs) and of some somatic cells, as well as in their cytoplasm (PubMed:16216237).
Interaction partners:
Sequence:
MALKAEDSFDIYSQLIQSFCRYAENTTVSESQSPAFNAQKEFQTCQDHACCTHSEAHTHILMQQWQLLEEQWEYIDHLKTDVAALKQLLHGFMNSLSGTDSGMEGTNHFLPPHQNPTLLKDEEIVASALNRPSVDINGFEENITTGAQIHAAFTKSPKKMPATSTPRKSEVLWSCSPTLATDGYFMLPDIILNPLDGKKLVSMLRSSNYEPHRFAELLFQHHVPHSLFQLWANKVNFDGSRGKLGLPRNLMIDILHQTSKRFVLGPKEKRKIKTRLNLLLRTRQDRAWWDVGL
Protein: adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) (Q583C8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Phosphodiesterase
- Phosphodiesterase
- 3', 5'-cyclic nucleotide phosphodiesterase, putative
Sequence:
MVTFMRELYVRDGAVTYLVFSLLLQVLTASSLANDKIQVKVYNMLYSNKISAKIYDPIIAGFNASITNGNPPSGANVEVVYVPPMDDSKYADYLGKHMTTNDGKELPVILGPVGDKNTLGLLKYFKEKNVTSFSPFTGSSKVRSWNPNLYFLTASPAAEMLALLRYAITQLRLHRLGFMYLKDVSYGDDEYKLAVELTTRMDRKLCGVFALKSQIGKESDDSSFSAEWNKFANARPQGVIVFGSPIPDTKKFLMKSLEDERTKGGYLLIPSTLQYVIKNKWAKELGRDRFVPDKIIITGTNPLAKDDGYDAIKRFKDDMAKYLKLNRNNFSKDNWNVNLNVDESNFTEQDTEAELMVDGWIAGEVLKQALSCREWLTSRDAFITSLYNQRRYVIDDIVVGDFGGECRGMAGERGASCLCNQGGNVVYMKKMGKDLRLYPMKEGVLALTSSRCYRDLSQLYAPLSGIMFKLTDDPKALRTAEAIYDGAFYVVGKGQLGHSDRFFLHWLSSKSHDTSTALYDEVEKRVVTAVFGVVDDSLLSTKGMAFIDPITLTPQLSNPRRNVIHLSPTLEQQLFVIVEHIIQNGAGKMHAIVRSGDTRGVRKVLQKTLKYFNASLSSFVASGEGSTLRDKLPTAGEVLVAGLISDDIPIILSHLGKHHNVRIFVPFFDVALLYDELVSAFRDKPFADRLLFATNLPHWGDKNTKSDMVREFHRVVRDESKWKPLSLLGYVAARAMINVLQRMGHVTPEELVDAIFSQSVITVDDMRYGPFDDKCTKKSLFGKKQCAVNYGATHISVWSMSRVLNPSVSPVVTHVTPSMKYGDTEGFRLKRGHIAAIAVSCVVVLALFVTVLVLVIRSSRRNARDNNNAPKEPTDPVTLIFTDIESSTAQWAAHPEQMPDLVATHHRLIRSLITRYECYEVKTVGDSFMIACKSPFAAAQLACDLQRDFLNHDWKTTELDESYREFERKRAEDDSDYTPPTASLDPEVYRQLWNGLRVRVGIHTGLCDIRHDEVTKGYDYYGRTSNMAARTESVGNGGQVLMTRSTYLSLSGEEREQLNVTPLGDVPLRGVPKPVEMYQLNAVPGRTFAALRLDREAEEEEDNVTGSITSESGSFAHGLNATAQQVAGCIDALLGTFPATQRQKMLATFCERWRVKKPPGMDAWNEASCRCVTRRIAAKVGCVMDFGTRNTSGSGGSFERGGSLFSPRGAAAVTLSSSSSSSCVEGRCGTVQLIEQENVSAAS
Protein: Stumps, isoform E (Q9VFI0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Fibroblast growth factor receptor homolog 1
- Fibroblast growth factor receptor homolog 2
- Long-chain-fatty-acid--CoA ligase heimdall
- Fibroblast growth factor
Sequence:
MFVTVDNTNTFFSDNPYYFCNETKSPRTPDSQSSSRGFSIFKRRNSKGSSPRPLVMTNPEQMRLITSANLDTTATMALGSPRGSFNSLAGYPQHAIELQTMNMYRQRSANSHSEFRERLNSCNETHSSQCPGGGGASVAGDHDEVFNPLTSPTSKSHRHHTLPSGGTRRHSLGNWAQHQHQQQHQQNSGAMGLGSPDEVPSMMAPRPPLLSPNKFRGSSHRRRDNCGNVNNTSGSSASGFLGSPGYNMDDILIITAKHSERAYLRATFLKNHFDKITKQRGRKPFNFLHIKIDDGPFSEEIAHKYQNTALQIVILCPALLALPHSFLMTQLSAIIRVEKVLAILLDVSEEKVKEMHKSALPSYYKWRRCVVRDNDQVQISNILGIATDILGRALCQRPPCQDSSGGGGGGLSRSFSSCTEGFTVLPKKVKLGQNKVVALLAEPLEKNDTLKLQVEKSGELIELRNFKCRNPYTLQFNIPEACMEISTMIEIRIEKNNKSLGARPIKCESRLRELEQLLRIEDSPIEFMCHALGIGPVERDALDQHLLQCFQRNMPPNFHLLSGPSERQPHFFTRLESSPEEYPTLLHFAARWGLNRLCIQLMECPGGDTACGVRNCAGRTPAELAEQEGHHKLAQNIVSFAEFHELTTMYHYFKGVTPPGESCPKPSANVVIEAHPVKAGKTNKPPKELPTAEYMEMSSGSERENTPEVRTKTETLAISNLNYISVETEDENLQASVAEKKVESEKKLPEAGNQPGPEKTTNELRINEPPYYQSKEQNQQPKELKNQSKSLDEVDAAPLYQTDKFSQECSQLLENQLGNDYVLQPSNVPVAQDDGNYLFQPSNRPVEEPLRLNRCTNRQPGYGTLKRSASDASAASHTRSNADDELAEIMHDFKNNVLSIRDVEVLVERWKHRNDVQQSFREKQDQIDQLRREYERIQEQVKSHLKRETPFERIKKFFLRSKTPGGNDSLLDETKSSIATSCSFKSAGGVSSSAGAGRPISSLSLQSVSSSSSSSGRLSTGSNCSGASLGDSGTHSDHEDRRFPHCRMMDNYMVPPTPRPVFTPSSTPGDERHQIVFPSPMSSCQRLNTPTSPTGSEHYQMFPSNIPVYGSQPLVGSQSSNYLNTIMEAKEQAETQHYQNQNGVTLQPIKLNERSNIIYGKLTKSSSASGCSSFKPKQIPVPCPQVGSIEVQAEVYQNVGDVAPEKDSKAEEETPNYMNC
Protein: Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Q6PHF0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Charged multivesicular body protein 2a
- Vesicle
- Charged multivesicular body protein 3
- vesicle-fusing ATPase
- vesicle-fusing ATPase
- IST1 homolog
- Charged multivesicular body protein 2Ba
- Charged multivesicular body protein 2b
- Charged multivesicular body protein 4c.
- Charged multivesicular body protein 4c
Sequence:
MDDTLFQLKFTSKQLERLAKKAEKDSKSEQAKVKKALQQKNVECARVYAENAIRKKNEGLNWLRMASRVDAVASKVQTALTMKGVAKNMTQVTKALDKALSSMDLQKVSAVMDKFETQVQNLDVHTSVMEDSMSSATTLSTPQQQVDDLILQIAEESGLEVEDQLSQLPAGASALGETSARAQEKEDQLSRRLAALRN
Protein: Neurocrescin (Q789F1)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Early endosome {ECO:0000256|ARBA:ARBA00004412}.
Interaction partners:
Sequence:
MEAHAEMENIKAIATVSENTKQEAIDEVKRQWQEEVASLQAIMKETVRDYELQYHHRMEQERAQWNQYRENVEREIAELRRRLSEAQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKEKLIEAEEKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDDQQRLSKRKEQKQKDSDDETKASCSLAHEESLTQFSNEEVHLNSTHSSVHSLDADLLLSSGESFNKSENDMFKDGLRRAQSTDSLGTSGSLQSKALGYNNKAKSAGNLDESDFGPLVGADSVSENYDTASLGSLQMPSGFMLTKDQEKAIKAMTPEQEETASLLSSVTQGVESAYVSPSGYRLVSETEWNLLQKEVQNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQVMLRQANDQLEKTMKDKQELEEYMKQSAEDSSNQISLLMVKCQKSENFLNELQQAFSQAKRSVQEQMAVLTQSREQVSEELVRLQKDNESLQGKHSLHVSLQQAEDFILPEAAEELRELILKYREDIISVRTAADHLEEKLKAEILFLKEQIQAEQYLQENIEETLQLEIENCKEEIASISSLKAELERIKVEKEQLESSSQEYLQQLESLQETKNTLEEQLKKETAAKANLEQLVFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
Protein: Misfire, isoform C (B7Z0E9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MFPFLKYRFHPFKGKTPVVKNTTTPVWNYEINFAWMYPSVAQRFLILIFAHEHLQWKCVAEFELCLEEIAFNGTPSLGPTYLHLYDPVNPMIYVGRLLMELRSEMLTDSQPTHTLSSKTVPGLDETRFWHDDVYLIEFLPLMGHHILTSGTAYKISARLAEHTSNVLEGQLRTPLDRFKSAMNSKNFRREAPFQSCMFRVRLPDNRAKYESDFFMLDIVNYMRSELDTFKLFQRKYPLQDDEQAKCLKVIVNNILTRIKEGLDAHRFDHDVQPQRTTWDINRQLYLLDYFAKLPLELQNLKQKLRSCFLEHLDTSIGDVVNELQRLVAEIGSLSSMARTQDEWPELVLSLSASGKDVGVCRLNAKLFLNLRNQDADQDQETLCWRLKSFSFKSAGCSHTCPNCGCTTAIVSGCLSIVVERERKRFLAVVNKEWANIEPMLWQLNPEQTHFLCHVYIHQAKVRPGGEKKNICDSHLRVLFADQACETYTSPGTLSPIWNAVITFNWVSLPGGIGLYLKNPPLLSLEFYNSERSLPEDLVGMGSVAMSVISEDRASDSNWEDAGVFGCSKNPLRKLQRLKYLTPPPLKWVPIARKGTLQAEVLMSAEIIQISMESLTTGQNDKKEPQLATGIPMAIRPTMQNFVLEVFFVGLRNYSKSSMSSAGKRKINLMMGDLVLSSGPSTARIRNSINFLVAYASGVVSLPDQQDYWPAIIATDVLLSGFSSESILGAALIPNSSNFLQRDRTLKCVFKKEQEAAEASTTVSVDEDDEDEEEELEWEEEETKPSRISSWWMRLLFAFGLRPAPYANRHALRFHDDLDDHELVEEREFTWWTKFYNSMYWSAAEMCHEHKHRLVIYYEELEKQAQFGYLQDWAVPVQLVHGVKFKKHGPPKEDIYATLKLQLKLTPCQCPVLEDPGGGGDMVRNMSNPIHPRHQSTLQSLGETVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEATLPGDHMLQVMVYDHDKIKDEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEILIDLCQKRGIQAPYYYGNVIEVDGMLFGDETLISKDEELQERLSLAVLKNMDKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPSPIDITPVPPADFEVRVVVKNLVGIQAGDKNIFGKLMSDVYVIGWCEDEDKRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLMVIRRKAGLLEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCKPYPKKRKRINLFKRKVINGWFPLQSNAHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPPMALEPPYTSSGQSFESMSCGLCSY
Protein: ATP-dependent helicase HRQ1 (EC 3.6.4.12) (Homologous to recQ protein 1) (Q05549)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Helicase with 3'-5' helicase activity involved in genome stability. Functions in the RAD4-dependent nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair. Unwinds relatively long duplex DNA up to 120-bp and requires a long 3'-tail of at least 70 nucleotides for efficient unwinding of duplex DNA. Activity is significantly stimulated by a preexisting fork structure. Shows both processive helicase and DNA strand annealing activities. Affects telomere length by a non-catalytic mechanism, probably through inhibiting telomerase by competing with it for ssDNA binding.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- ATP-dependent DNA helicase PIF1
- DNA cross-link repair protein PSO2/SNM1
- Putative ATP-dependent helicase IRC3
- DNA polymerase zeta catalytic subunit
Sequence:
MEEGPIKKKLKSAGQGSGKTDAFRNFEQFFFRLNTLYTFLICRKHVVPTFKTLCGPIETALKRTVTKEDLAMVMALMPRECVFKYIDENQIYTETKIFDFNNGGFQQKENDIFELKDVDDQNQTQKSTQLLIFEFIDGTMQRSWSASDRFSQIKIPTYTTEEMKKMISKREALFKSRLREFILEKEKANLDPFSELTNLAQKYIPRERDYEDPIEAMMKAKQESNEMSIPNYSNNSVITTIPQMIEKLKSTEFYASQIKHCFTIPSRTAKYKGLCFELAPEVYQGMEHENFYSHQADAINSLHQGENVIITTSTSSGKSLIYQLAAIDLLLKDPESTFMYIFPTKALAQDQKRAFKVILSKIPELKNAVVDTYDGDTEPEERAYIRKNARVIFTNPDMIHTSILPNHANWRHFLYHLKLVVVDELHIYKGLFGSHVALVMRRLLRLCHCFYENSGLQFISCSATLKSPVQHMKDMFGINEVTLIHEDGSPTGAKHLVVWNPPILPQHERKRENFIRESAKILVQLILNNVRTIAFCYVRRVCELLMKEVRNIFIETGREDLVTEVMSYRGGYSASDRRKIEREMFHGNLKAVISTNALELGIDIGGLDAVLMCGFPLSMANFHQQSGRAGRRNNDSLTLVVASDSPVDQHYVAHPESLLEVNNFESYQDLVLDFNNILILEGHIQCAAFELPINFERDKQYFTESHLRKICVERLHHNQDGYHASNRFLPWPSKCVSLRGGEEDQFAVVDITNGRNIIIEEIEASRTSFTLYDGGIFIHQGYPYLVKEFNPDERYAKVQRVDVDWVTNQRDFTDVDPQEIELIRSLRNSDVPVYFGKIKTTIIVFGFFKVDKYKRIIDAIETHNPPVIINSKGLWIDMPKYALEICQKKQLNVAGAIHGAQHAIMGMLPRFIVAGVDEIQTECKAPEKEFAERQTKRKRPARLIFYDSKGGKYGSGLCVKAFEHIDDIIESSLRRIEECPCSDGCPDCVAASFCKENSLVLSKPGAQVVLHCILGHSEDSFIDLIKDGPEPNMPEIKVETVIPVSEHVNFSDDFKIIDVRRATKDDTHTNEIIKKEI