wanglab/gogpt-training-data huggingface dataset:
Protein: Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) (Q9H5I1)
Organism: Homo sapiens (Human)
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:30111536}. Chromosome, centromere {ECO:0000250}. Note=Associates with centromeric constitutive heterochromatin. {ECO:0000250}.
Interaction partners:
- Chromobox protein homolog 1
- Eukaryotic translation initiation factor 2 subunit 3
- Chromobox protein homolog 5
- Histone H3.1
- Histone H3.2
- Chromobox protein homolog 3
- Calmodulin-lysine N-methyltransferase
- DNA
- Histone H3.3C
- Histone H3.3
Sequence:
MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
Protein: Cyclin-B1-4 (G2/mitotic-specific cyclin-B1-4) (CycB1;4) (O48790)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinase B2-2
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinase A-1
- Cyclin-dependent kinase B1-1
- Wee1-like protein kinase
- Protein FIZZY-RELATED 2
- Cell division cycle 20.4, cofactor of APC complex
- Mitotic spindle checkpoint protein MAD2
- Cell division cycle 20.1, cofactor of APC complex
Sequence:
MASSRVSDLPHQRGIAGEIKPKNVAGHGRQNRKVLGDIGNLVTGRDVATGKDVAKKAKQPQQQTKAEVIVISPDENEKCKPHFSRRTHIRGTKTFTATLRARSKAASGLKDAVIDIDAVDANNELAAVEYVEDIFKFYRTVEEEGGIKDYIGSQPEINEKMRSILIDWLVDVHRKFELMPETLYLTINLVDRFLSLTMVHRRELQLLGLGAMLIACKYEEIWAPEVNDFVCISDNAYNRKQVLAMEKSILGQVEWYITVPTPYVFLARYVKAAVPCDAEMEKLVFYLAELGLMQYPIVVLNRPSMLAASAVYAARQILKKTPFWTETLKHHTGYSEDEIMEHAKMLMKLRDSASESKLIAVFKKYSVSENAEVALLPSLDDFSVSCA
Protein: Ubiquitin-conjugating enzyme E2 variant 1A (Ubc enzyme variant 1A) (Protein MMS ZWEI HOMOLOG 1) (Q93YP0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has no ubiquitin ligase activity on its own. The heterodimer with UBC catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. May play a role in the control of progress through the cell cycle and differentiation. Probably not involved in the error-free DNA repair.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 35
- F-box family protein-like protein
- Ubiquitin-conjugating enzyme E2 13
- Membrane-anchored ubiquitin-fold protein 4
- F-box protein At5g36730
- F-box protein At5g36820
- Membrane-anchored ubiquitin-fold protein 5
- F-box/LRR-repeat protein 4
- Ubiquitin-conjugating enzyme E2 36
- Membrane-anchored ubiquitin-fold protein 6
Sequence:
MSSEEAKVVVPRNFRLLEELERGEKGIGDGTVSYGMDDADDIYMQSWTGTILGPPNTAYEGKIFQLKLFCGKEYPESPPTVRFQTRINMACVNPETGVVEPSLFPMLTNWRREYTMEDILVKLKKEMMTSHNRKLAQPPEGNEEARADPKGPAKCCVM
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) (DmOST50) (DrOST) (OST5OP) (Q24319)
Organism: Drosophila melanogaster (Fruit fly)
Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- dolichyl-diphosphooligosaccharide--protein glycotransferase
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
- GH11935p
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- DSec61alpha
- Inactive rhomboid protein 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
- Transmembrane protein 258
Sequence:
MMWKALLIAVLAIAHCQAVLETDANTLVLLDNLAIRETHSIFFKSLQDRGFKLTYKLADDSSLLLSKYGEYLYKNVIIFAPSVEEFGGDVSVERLAQFVDDGGNVLVAGSEKSGDALREFASECGFELDEENAAVIDHLHYDVSDAGEHTTILTSAKNLIQADTIVGKANRQADAAPLLYRGTGLIADKENPLVLKLLTAESTAYSYNPEASVSDYPHAVGRGTLLIAALQARNNARVVFSGSLLFFSDESFTTAVQYAQSGVFHKLAGNRDVAESISKWVFGETGRLRVASVQHHKEGELLPPDQAYTITDPVVYTIGIEELVQGEWRAFKASDIQLEFVRIDPFVRTYLKQTNTGAYQAKFKIPDVYGVYQFKVDYNRVGYTHLYSTTQVSVRPLEHTQYERFIPSAFPYYTSAFSMMIGVFVFSFVFLHFKDEPVGRAAKEDKKSQ
Protein: cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) (P22612)
Organism: Homo sapiens (Human)
Function: Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
Interaction partners:
- cAMP-dependent protein kinase type II-beta regulatory subunit
- A-kinase anchor protein 1, mitochondrial
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- Ezrin
- A-kinase anchor protein 5
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- cAMP-dependent protein kinase type I-beta regulatory subunit
- Cyclic AMP-responsive element-binding protein 1
- Ryanodine receptor 2
- Calmodulin-1
Sequence:
MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
Protein: Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form] (Q60649)
Organism: Mus musculus (Mouse)
Function: Function as a regulatory ATPase and participates in secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Plays a role in granulocyte differentiation.
Subcellular location: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9H078}.
Interaction partners:
- ATP-dependent Clp protease proteolytic subunit, mitochondrial
- GrpE protein homolog 2, mitochondrial
- ATP-dependent clpX-like chaperone, mitochondrial
- GrpE protein homolog 1, mitochondrial
- Stress-70 protein, mitochondrial
- 10 kDa heat shock protein, mitochondrial
- Lon protease homolog, mitochondrial
- Heat shock 70 kDa protein 4
- Heat shock 70 kDa protein 1B
- DnaJ homolog subfamily A member 3, mitochondrial
Sequence:
MMLSAVLRRTTPAPRLFLGLIKSPSLQSRGGAYGRGVVTGDRGEPQRLRAAAWVRPGASSTFVPGRGAATWGRRGERTEIPYLTAASSERGPSPEETLPGQDSWNGVPNKTGLGMWALAMALVVQCYSKNPSNKDAALMEAARANNVQEVRRLLSEGADVNARHKLGWTALMVASISHNESVVQVLLAAGADPNLGDEFSSVYKTANEQGVHSLEVLVTREDDFNNRLNHRASFKGCTALHYAVLADDYSIVKELLDRGANPLQRNEMGHTPLDYAREGEVMKLLKTSETKYMEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYIGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQMSDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKHLLKSPELPSPQAEKRPPTLRLEIIDKDSKTRKLDIQAPLHPEKVCYTI
Protein: Glycerate dehydrogenase HPR, peroxisomal (GDH) (EC 1.1.1.29) (NADH-dependent hydroxypyruvate reductase 1) (AtHPR1) (HPR 1) (Q9C9W5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the NADH-dependent reduction of hydroxypyruvate into glycerate in the photorespiratory core cycle. Mediates fatty acid beta-oxidation in germinating seeds when malate dehydrogenase is absent.
Subcellular location: Peroxisome {ECO:0000269|PubMed:9177031}.
Interaction partners:
- Serine--glyoxylate aminotransferase
- Phosphoglycolate phosphatase 1A, chloroplastic
- Glutamate--glyoxylate aminotransferase 1
- D-glycerate 3-kinase, chloroplastic
- Glycolate oxidase 1
- Glycolate oxidase 2
- Glutamate--glyoxylate aminotransferase 2
- Malate synthase
- Glycolate oxidase 3
- Peroxisomal
Sequence:
MAKPVSIEVYNPNGKYRVVSTKPMPGTRWINLLVDQGCRVEICHLKKTILSVEDIIDLIGDKCDGVIGQLTEDWGETLFSALSKAGGKAFSNMAVGYNNVDVEAANKYGIAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRGGLYEGWLPHLFVGNLLKGQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQSTRLEKFVTAYGQFLKANGEQPVTWKRASSMEEVLREADLISLHPVLDKTTYHLVNKERLAMMKKEAILVNCSRGPVIDEAALVEHLKENPMFRVGLDVFEEEPFMKPGLADTKNAIVVPHIASASKWTREGMATLAALNVLGRVKGYPIWHDPNRVDPFLNENASPPNASPSIVNSKALGLPVSKL
Protein: PLASMODESMATA CALLOSE-BINDING PROTEIN 5 (AtPDCB5) (Glucan endo-1,3-beta-glucosidase-like protein 1) (Q9M2K6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:19223515}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19223515}. Cell junction, plasmodesma {ECO:0000269|PubMed:19223515}.
Interaction partners:
- Calcineurin B-like protein 7
Sequence:
MIMSLPQCSHLRLSILAATAAMLMVITTAQIGGQVIQVELWCVAKNNAEDSSLQTAIEWACGQGGADCGPIQQGGPCNDPTDVQKMASFVFNNYYLKNGEEDEACNFNNNAALTSLNPSQGTCKYPSSKGANNGRLADDTSMGAGQADMSRGGRPISSSWMVTFIGFGSLLTMTWIIHHL
Protein: Tryptamine hydroxycinnamoyltransferase 1 (OsTHT1) (EC 2.3.1.-) (Q338X7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydroxycinnamoyl transferase that catalyzes the transfer of an acyl from p-coumaryol-CoA to tryptamine, to produce coumaroyl tryptamine. Serotonin, tyramine, and to a lesser extent agmatine, serve as acyl acceptors in vitro. Can use caffeoyl-CoA, and to a lesser extent benzoyl-CoA, as acyl donors.
Interaction partners:
- FAD-dependent oxidoreductase domain-containing protein 1
- Aminomethyltransferase
- Monodehydroascorbate reductase 1, peroxisomal
- Monodehydroascorbate reductase 5, chlorplastic
- Monodehydroascorbate reductase 4, cytosolic
- Monodehydroascorbate reductase 3, cytosolic
- Monodehydroascorbate reductase 2, peroxisomal
- Os12g0153600 protein
- thymidylate synthase
- Putative bifunctional dihydrofolate reductase-thymidylate synthase
Sequence:
MAAVTVEITRSEVLRPSPASAGGGEMVPLTVFDRAATDGYIPTMFAWDAAAAAALSNDAIKDGLAAVLSRFPHLAGRFAVDERGRKCFRLNNAGARVLEASAAGDLADALAHDVAAHVNQLYPQADKDRVDEPLLQVQLTRYTCGGLVIGAVSHHQVADGQSMSVFFTEWAAAVRTAGAALPTPFLDRSAVAAPRIPPAPAFDHRNVEFRGEGSRSHSYGALPLERMRNLAVHFPPEFVAGLKARVGGARCSTFQCLLAHAWKKITAARDLSPKEYTQVRVAVNCRGRAGPAVPTDYFGNMVLWAFPRMQVRDLLSASYAAVVGVIRDAVARVDERYIQSFVDFGEVAAGDELAPTAAEPGTAFCPDLEVDSWIGFRFHDLDFGGGPPCAFLPPDVPIDGLLIFVPSCAAKGGVEMFMALDDQHVEALRQICYSMD
Protein: Matrilin 2 (F1S0M0)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MEKMLVGCFLLILGQILLLPAEARGRLPSRSISKARHARTHPQTALLESSCENKRADLVFIIDSSRSVHTHDYAKVKEFLVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAIKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARNTGILIFAIGVGQVDFNTLKAIGSEPHEDHVFLVANFSQMESLTSVFQTKLCTVHMCSILEHNCAHFCINTPGSYVCRCKQGYILNSDQTTCRIQDLCAAEDHGCEQLCVNLLGSFVCQCYGGYTLAEDGKRCVAVDYCASENHGCEHECVNADTSYVCRCPKGFALNPDKKTCAKIDYCASPNHGCQHECVNTDDSYFCRCLKGFTLNPDQKTCRRINYCALNKPGCEHECINTEEGHYCRCRRGYTLDPNGKTCSRVDHCAEQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNTDRSFACQCPEGHVLRSDGKTCARKDVCQAVDHGCEHICVSGDESYTCRCLEGFRLAEDGKHCRRKDVCKSTHHGCEHMCVNRGNSYICKCSEGFILAEDGRRCKRCTEGPVDLVFVIDGSKSLGEENFEIVKQFVTGIIDSLTISPKAARVGLLQYSTQVRTEFTLRNFGSAKDMKKAVASMKYMGKGSMTGLALKHMFERSFTQIEGARPLSARVPRVAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTDKHLFYAEDFSTMGEISDKLQKGICEALEDSDGRQDSPAGELPKRVHQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLARSTQKLFHSTKSSGNFQVKYYHSKITRY
Protein: Guanine nucleotide-binding protein alpha-7 subunit (Q21917)
Organism: Caenorhabditis elegans
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha
- Nuclear hormone receptor family member nhr-22
- Guanine nucleotide-binding protein subunit beta-1
- Guanine nucleotide-binding protein subunit beta-2
- Guanine nucleotide-binding protein subunit gamma
- G protein gamma domain-containing protein
- Short-chain dehydrogenase/reductase 3
- G Protein, Alpha subunit
Sequence:
MGHCTSKDQKEGKRLNRRIDEQIKKDQSMSLRIIKLLLLGAGESGKSTILKQMRILHKDGFSQQDLEMIRPVVYSNCIHSMLSILRAMFHLQIEYGEPDRVRDSQLVFATVHANKEELTEELAAAMQRLWHDPGVRECYRRSNEYQIDDSAKYFLDNLPRLSSPNYVPSEQDLLRTRIKTTGITEVLFELKGLTFRVIDVGGQRSERKKWIHCFDNVNAIIFISSLSEYDQTLREDNCTNRMQESLKLFDSICNSPWFADIHFILFLNKKDLFAEKIVRSPLTVCFPEYKGQQNQTECINYIQWKFEQLNRSSQREIYCHHTCATDTNNVQFVLDACLDMIIAKNLKSMGLC
Protein: Dermatopontin (22 kDa extracellular matrix protein) (Dermatan sulfate proteoglycan-associated protein 22K) (Tyrosine-rich acidic matrix protein) (TRAMP) (P45846)
Organism: Sus scrofa (Pig)
Function: Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation (By similarity). Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:8082810}.
Interaction partners:
- Lumican
- Prolargin
- Decorin
Sequence:
QYGDYGYPYQQYHDYSDDGWVNLNRQGFSYQCPHGQVVVAVRSIFNKKEGSDRQWNYACMPTPQSLGEPSECWWEEINRAGMEWYQTCSNNGLVAGFQSRYFESVLDREWQFYCCRYSKRCPYSCWMTTEYPGHYGEEMDMISYNYDYYMRGATTTFSAVERDRQWKFIMCRMTDYDCEFANV
Protein: Endopolyphosphatase (EC 3.6.1.10) (Deoxyadenosine triphosphate phosphohydrolase) (dATP phosphohydrolase) (EC 3.6.1.-) (Exopolyphosphatase) (EC 3.6.1.11) (Phosphate metabolism protein 5) (Q04119)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths. Has both exopolyphosphatase and endopolyphosphatase activities at different ratios depending on divalent cations by cleaving phosphate from the chain end and by fragmenting long-chain polymers into shorter ones, respectively. The limited digestion products are 1 and 3 P(i) residues. Also releases phosphate from dATP. dATP phosphohydrolase activity is about 7-fold lower than the exopolyphosphatase activity (Ref.16).
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:11566881, ECO:0000269|PubMed:11788821, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15086787, ECO:0000269|PubMed:8900207}; Single-pass type II membrane protein {ECO:0000269|PubMed:11566881, ECO:0000269|PubMed:11788821, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15086787, ECO:0000269|PubMed:8900207}. Cytoplasm {ECO:0000269|PubMed:17009950}. Note=The cytoplasmic form appears in the cytosol during the transition of cells from stationary growth phase to new budding on glucose addition and phosphate excess. {ECO:0000269|PubMed:17009950}.
Interaction partners:
- Polyphosphatase
- Zinc-dependent endopolyphosphatase
- Phosphate system positive regulatory protein PHO81
- Vacuolar transporter chaperone complex subunit 4
- Diphosphoinositol polyphosphate phosphohydrolase DDP1
- Glycerophosphocholine phosphodiesterase GDE1
- Vacuolar transporter chaperone 3 complex subunit 3
- Vacuolar transporter chaperone complex subunit 1
Sequence:
MVVVGKSEVRNVSMSRPKKKSLIAILSTCVLFFLVFIIGAKFQYVSVFSKFLDDRGDNESLQLLNDIEFTRLGLTPREPVIIKDVKTGKERKLHGRFLHITDIHPDPYYVEGSSIDAVCHTGKPSKKKDVAPKFGKAMSGCDSPVILMEETLRWIKENLRDKIDFVIWTGDNIRHDNDRKHPRTEAQIFDMNNIVADKMTELFSAGNEEDPRDFDVSVIPSLGNNDVFPHNMFALGPTLQTREYYRIWKNFVPQQQQRTFDRSASFLTEVIPGKLAVLSINTLYLFKANPLVDNCNSKKEPGYQLLLWFGYVLEELRSRGMKVWLSGHVPPIAKNFDQSCYDKFTLWTHEYRDIIIGGLYGHMNIDHFIPTDGKKARKSLLKAMEQSTRVQQGEDSNEEDEETELNRILDHAMAAKEVFLMGAKPSNKEAYMNTVRDTYYRKVWNKLERVDEKNVENEKKKKEKKDKKKKKPITRKELIERYSIVNIGGSVIPTFNPSFRIWEYNITDIVNDSNFAVSEYKPWDEFFESLNKIMEDSLLEDEMDSSNIEVGINREKMGEKKNKKKKKNDKTMPIEMPDKYELGPAYVPQLFTPTRFVQFYADLEKINQELHNSFVESKDIFRYEIEYTSDEKPYSMDSLTVGSYLDLAGRLYENKPAWEKYVEWSFASSGYKDD
Protein: Platelet glycoprotein VI (GPVI) (Glycoprotein 5) (P0C191)
Organism: Mus musculus (Mouse)
Function: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Subcellular location: Cell membrane {ECO:0000305|PubMed:24368846}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- High affinity immunoglobulin epsilon receptor subunit gamma
- von Willebrand factor
- Tyrosine-protein kinase Lyn
- Tyrosine-protein kinase Fyn
- Galectin-3
- Collagen alpha-2
- Collagen alpha-1
- Integrin alpha-2
- Collagen alpha-1
- C-type lectin domain family 1 member B
Sequence:
MSPASPTFFCIGLCVLQVIQTQSGPLPKPSLQAQPSSLVPLGQSVILRCQGPPDVDLYRLEKLKPEKYEDQDFLFIPTMERSNAGRYRCSYQNGSHWSLPSDQLELIATGVYAKPSLSAHPSSAVPQGRDVTLKCQSPYSFDEFVLYKEGDTGSYKRPEKWYRANFPIITVTAAHSGTYRCYSFSSSSPYLWSAPSDPLVLVVTGLSATPSQVPTEESFPVTESSRRPSILPTNKISTTEKPMNITASPEGLSPPFGFAHQHYAKGNLVRICLGATIIIILLGLLAEDWHSRKKCLQHRMRALQRPLPPLPLA
Protein: Keratin, type I cytoskeletal 13 (Cytokeratin-13) (CK-13) (Keratin-13) (K13) (Type I keratin Ka13) (Q6IFV4)
Organism: Rattus norvegicus (Rat)
Function: Type 1 keratin (Probable). Maintains postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially via regulation of the G1/S phase cyclins CCNE1 and CCNE2 (By similarity).
Interaction partners:
- Keratin, type II cytoskeletal 4
Sequence:
MSCRFQSSSMSYGGGFGAGSCQLGGGRNISTCSSRFVTGGSSGGYGGGMSCGFGGGAGGGYGGGFGGGFGGSCGGGFGGGFGDFGSVDGGLLSGNEKITMQNLNDRLASYLEKVRALEAANADLEVKIRDWHLKQSPTSPERDYSAYYKTIEELRIKILEATTDNNRIVLEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLAKTDLEMQIESLNEELAYLKKNHEEEMKEFSNQAVGQVNVEMDATPGIDLTRVLAEMREQYEALAEKNRRDAEAWFQAKSAELNKEVSSNAAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLESTLAETECRYALQLQQIQALISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMTGFNTGGNSTTTSNTSTSPSTSGRPDFRKY
Protein: tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase (EC 2.8.4.3) ((Dimethylallyl)adenosine tRNA methylthiotransferase MiaB) (tRNA-i(6)A37 methylthiotransferase) (P0AEI1)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01864}.
Interaction partners:
- tRNA dimethylallyltransferase
- Dual-specificity RNA methyltransferase RlmN
- Iron-sulfur cluster carrier protein
- tRNA-cytidine
- tRNA-modifying protein YgfZ
- Biotin synthase
- tRNA-specific 2-thiouridylase MnmA
- Endoribonuclease YbeY
- tRNA sulfurtransferase
- PhoH-like protein
Sequence:
MTKKLHIKTWGCQMNEYDSSKMADLLDATHGYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWKLLKEKNPDLIIGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGSFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRILNLMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETTEDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGTPDMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAETPESVIARTRKENDLGVGYYQP
Protein: Islet amyloid polypeptide (IAPP) (Amylin) (Diabetes-associated peptide) (DAP) (Insulinoma amyloid peptide) (P10997)
Organism: Homo sapiens (Human)
Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Subcellular location: Secreted {ECO:0000269|PubMed:17374526}.
Interaction partners:
- Calcitonin receptor
- Receptor activity-modifying protein 3
- Receptor activity-modifying protein 1
- Receptor activity-modifying protein 2
- Pro-adrenomedullin
- Calcitonin gene-related peptide 2
- Calcitonin gene-related peptide type 1 receptor
- Insulin-degrading enzyme
- Calcitonin
- Insulin
Sequence:
MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL
Protein: Growth arrest-specific protein 1 (GAS-1) (Q01721)
Organism: Mus musculus (Mouse)
Function: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Sonic hedgehog protein
- Protein patched homolog 1
- Cell adhesion molecule-related/down-regulated by oncogenes
- Brother of CDO
- Protein patched homolog 2
- Desert hedgehog protein
- Indian hedgehog protein
- Low-density lipoprotein receptor-related protein 2
- Growth arrest-specific protein 2
- Protein smoothened
Sequence:
MLAALLGGAGARTGTLPGALLCLMALLQLLCSAPRGSGLAHGRRLICWQALLQCQGEPDCSYAYSQYAEACAPVLAQRGGADAPGPAGAFPASAASSPRWRCPSHCISALIQLNHTRRGPALEDCDCAQDEHCRSTKRAIEPCLPRTSSVGPGAGAGSVMGCTEARRRCDRDSRCNLALSRYLAYCGKLFNGLRCTDECRAVIEDMLAVPKAALLNDCVCDGLERPICESVKENMARLCFGPDASNGPGSSGSDGGLDDYYDEEYDDEQRAGAAGGEQPLDDDDGLARPGGGAAAAGGRGDLPHGPGRRSSSSGSGGHWANRSAWTPFACLLLLLLLLLGSHL
Protein: Uncharacterized membrane protein YJL163C (P46996)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Uncharacterized membrane protein YMR155W
- Vacuolar basic amino acid transporter 2
- Vacuolar basic amino acid transporter 1
Sequence:
MSNEDETTRLMSSDEMDYLLETAGINALEEIISQNDSTGINLDTNETAQDSSYDSIRRSPSILSVAKSVEGEHGRRKLLCLYGLVMIICIAESISMTATIPLVMDKVAEGISDENGHYDSVAVQTIVSSISSSTMMIAGAISIFMAGKWGELSDRIGRVRVFKYMSGIRVIGLLTHVFTLSSKMKYHKWAIVLTACIVPSFGGLFALVANGNSYVSDIVKTEHRMVTIGIMMSCIYATMGVGPMFGSFLVKWTHGNGFIPIYTSIAFVILALIICETIMVEPRHETQMAHSQSTYTKRREKLRSQSGSDDARNYQSVTYGKFQIMRLMDLLAPVKKLWLKPDSAGSLVPRHTVILLIVLDILFVCGTTSCMPALILFSTYEYKWHAVELGYFISILGIGRGVVLLVVSPTLLYTLKRIYQHLNHSIDKIDIFCIQFSMIVITLSLFVMIRFGEKTPTSMIIFALLQALSAFCSPTLQSGIIKYTSKKHTGEMFGAMALVRSCVMLVIPPILLKLYGSTVSVNPSLFMYIPFSTSIVAILLTFFLRIYKNPPLDGP