wanglab/gogpt-training-data huggingface dataset:
Protein: Interleukin-24 (IL-24) (IL-4-induced secreted protein) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Th2-specific cytokine FISP) (Q925S4)
Organism: Mus musculus (Mouse)
Function: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I intereferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (By similarity). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q13007}.
Interaction partners:
- Interleukin-20 receptor subunit alpha
- Interleukin 20 receptor beta
- Interleukin-22 receptor subunit alpha-1
- Interleukin-19
- Interleukin-20
- Interleukin-10 receptor subunit beta
- Interleukin-10 receptor subunit alpha
- Interleukin-22 receptor subunit alpha-2
- Interleukin-22
- Interleukin-4 receptor subunit alpha
Sequence:
MSWGLQILPCLSLILLLWNQVPGLEGQEFRSGSCQVTGVVLPELWEAFWTVKNTVQTQDDITSIRLLKPQVLRNVSGAESCYLAHSLLKFYLNTVFKNYHSKIAKFKVLRSFSTLANNFIVIMSQLQPSKDNSMLPISESAHQRFLLFRRAFKQLDTEVALVKAFGEVDILLTWMQKFYHL
Protein: Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) (P48036)
Organism: Mus musculus (Mouse)
Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Interaction partners:
- Caspase-3
- Caspase-8
- Apoptosis regulator Bcl-2
- Glyceraldehyde-3-phosphate dehydrogenase
- Cholecystokinin
- Actin, cytoplasmic 1
- Caspase-9
- Cellular tumor antigen p53
- Peroxidasin homolog
- Poly [ADP-ribose] polymerase 1
Sequence:
MATRGTVTDFPGFDGRADAEVLRKAMKGLGTDEDSILNLLTSRSNAQRQEIAQEFKTLFGRDLVDDLKSELTGKFEKLIVAMMKPSRLYDAYELKHALKGAGTDEKVLTEIIASRTPEELSAIKQVYEEEYGSNLEDDVVGDTSGYYQRMLVVLLQANRDPDTAIDDAQVELDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVVVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGGEDD
Protein: Centromere protein H (A8WHV8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000256|ARBA:ARBA00004629}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Centromere protein I
- Centromere protein M
- Centromere protein K.
- Centromere protein T
- Centromere protein P
- Centromere protein O.
- Centromere protein N
- Centromere protein X
- Centromere protein S
- Centromere protein W
Sequence:
MSSSNVNHDALASDVDTPRRDNSLPDPSSVSDGVTPTSLLKMKEIMENQCFEMNVKVSMGKHRESCEAEADLSKYESEIEQARLSHFNKTLVLNRMQIWSAVIEKMIQNGADAEELKELTNQNSEICEKTIQILKETRELQDQITDVQKQRLDLKGQIKKKMQEINELKQEKENQGEVQQKTKERAEAVLQKYQRITTILQNVLRGIILASKVNWREDPKLSDIVMKLEHIPS
Protein: Nuclear intron maturase 3, mitochondrial (AtnMat3) (EC 3.1.-.-) (Nuclear intron maturase 2 a) (AtnMat2a) (Q9LZA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Nuclear-encoded maturase required for splicing of group-II introns in mitochondria. Necessary for mitochondrial biogenesis during early developmental stages.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:19946041}.
Interaction partners:
- Nuclear intron maturase 1, mitochondrial
- Pentatricopeptide repeat-containing protein At3g22670
Sequence:
MVLRLRVHSFYNRGISFLVSSSLRNLSTASSLFLNSDQTITEPLVKSELEALVLKQYSHGKFYSLVKNAVSLPCVLLAACQNLSLSANSSGDLADRVSRRFSIEEMGREIREGRFDIRSCCVEFISSSLVLPNLKLKVLIEAIRMVLEIVYDDRFATFSYGGRVGMGRHTAIRYLKNSVENPRWWFRVSFAREMFEERNVDILCGFVGEKINDVMLIEMIKKLFEFGILKIELGGCNSGRGFPQECGLCSILINVYFDGLDKEIQDLRLKMKVKNPRVGTGDEESTGNVFFKPVNIYAVRYLDEILVITSGSKMLTMDLKKRIVDILEQRLELRVDRLNTSIHSAVSEKINFLGMYLQAVPPSVLRPPKSEKAVRAMKKYQRQKDVRKLELRNARERNRKTLGLKIFRHVLKKIKQSNGFKFEGEIENEVRDIFQSWGEEVMQDFMGSLEERWKWHWLLTRGDFLSLRHIREKLPQDLIDAYDEFQEQVDKHLAPTQAKKVLEDEERRVEEEEEQRYAERTVEDLTKLCMKVSAPEELVRKAIKLVGFTNSMGRPRPIIHLVTLEDSDIIKWYARHEKHGSTKKLIRHYTKDLRVSDLDGREEAHFPSEREVKMMGDKNLSDPKPVDGTLSLLLIRLASDEPLHHCAASFCERSDTIMHRVHLLQNRLHINPLDEEKWVPGMGTIHSALNRKCLPLCSTHISDVYLGKITLQDVDSSSFIDLR
Protein: Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (EC 3.1.2.2) (Acyl-CoA thioester hydrolase 9) (Q9Y305)
Organism: Homo sapiens (Human)
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q9R0X4}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q9R0X4}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9R0X4}.
Interaction partners:
- Acyl-coenzyme A thioesterase 2, mitochondrial
- Acyl-coenzyme A thioesterase 8
Sequence:
MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSPLSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQLHGDEFCPVLDATFVMVARDSENKGPAFVNPLIPESPEEEELFRQGELNKGRRIAFSSTSLLKMAPSAEERTTIHEMFLSTLDPKTISFRSRVLPSNAVWMENSKLKSLEICHPQERNIFNRIFGGFLMRKAYELAWATACSFGGSRPFVVAVDDIMFQKPVEVGSLLFLSSQVCFTQNNYIQVRVHSEVASLQEKQHTTTNVFHFTFMSEKEVPLVFPKTYGESMLYLDGQRHFNSMSGPATLRKDYLVEP
Protein: CCM2 scaffold protein (C9JUH3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA
Protein: histone acetyltransferase (EC 2.3.1.48) (O60424)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
YVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL
Protein: Uncharacterized protein (A8DYZ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLKNVTMLTSCLWTTLPWIVLGQTYYMSFIFNNYGPSRISAPQLGFNGTAREPVEGDNVKISSVEHSDEGDTLEVSSLEHSLESKHNSKKDKIMETLELSSEHHSREKSETKKPSVEDKDLSDSAETMTWSTTKQIKSTTMKKTKATTYETPEMPNEITTESTMATAIDKEKTTVEIYTESPKEKFTDLPGIGKEPSDSNTQSFSSRSWEPVTPHPSAFFDYPEATCSEDMDLHEVFGIRLERDRGLPTKILCTFKNKWGGPWLLMTRIELPVRVHMRHWFLGYLTADYKDMNINFLALAHIMNSMRTAMLILGQDKDNKLVYNLYDDVVISAFNDLFMMRKAELVEANTTELLFVSVGKVLSSYAGRNRSCPLQVLGSWWGHHSVQDMYQGFFCIFPKDRIISKPGYVAIFIKPSLFPANNTALYDHPISTRRPWSNNNYNTKILNETEKNSKAYKKEQKLEWERNKMAVQKELDRRARIFEAIDRLRIEEAQRHRGR
Protein: Undifferentiated embryonic cell transcription factor 1 (Q5T230)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional coactivator of ATF2.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein NANOG
- POU domain, class 5, transcription factor 1
- Developmental pluripotency-associated protein 3
- Sal-like protein 4
- Transcription factor SOX-2
Sequence:
MLLRPRRPPPLAPPAPPSPASPDPEPRTPGDAPGTPPRRPASPSALGELGLPVSPGSAQRTPWSARETELLLGTLLQPAVWRALLLDRRQALPTYRRVSAALAQQQVRRTPAQCRRRYKFLKDKFREAHGQPPGPFDEQIRKLMGLLGDNGRKRPRRRSPGSGRPQRARRPVPNAHAPAPSEPDATPLPTARDRDADPTWTLRFSPSPPKSADASPAPGSPPAPAPTALATCIPEDRAPVRGPGSPPPPPAREDPDSPPGRPEDCAPPPAAPPSLNTALLQTLGHLGDIANILGPLRDQLLTLNQHVEQLRGAFDQTVSLAVGFILGSAAAERGVLRDPCQ
Protein: P-type ATPase (Q55DN5)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Probable copper chaperone for superoxide dismutase
- Copper transport protein ATOX1 homolog
Sequence:
MGDFKGEDDNYDYDEGIPLFNQVIFTNSYNNSKVVLDDNQDDIIFITPPSPPPTLQTKKQCEKGCCGEKKSLLTNNDEDRDKDEDEEEDDDDGVPKNYKSNSNVGSIVSLDMDSLNSAIIMEPNFQKDYTISSPVVTTTTTTTTTTTSNDNCKKGCCPTPSDDEKMITKDDKGSCKKGCCSSSSKTTETNDIGCKKGCCPTEQPKQQVESTKTYCCNICVTGHCCKVDCCKQVCCLTYSVGVPNFSFMRSSSSSDDNNNDYNSDQQRKKRIFATMFSKTCGTFGFKVGYSELNEDKVDIEQQEERDNKGLSTNNNVSIELLPITTTNNFKNSTGIKSSQSSTLSKSLEKVELHLMISGMTCADCVTTLEQKMKSLSGVNEIQTSLFTGKCKINYSPMIIQPQQILQVIENIGFVGKQVHGQSSNSNQITIEIISLSPTSTLTTILNDQLIENIKLSIDGVLDAIEESGSVNDKLTIVYDTDKIGPRNLLKEIQLIFGDNFKIQPNTKLNNNNNSNNKNNNSKDNNNNNLKSLLMFCILLFIPTILISYIFPNIKSVKEVMEFEIGKGITMSILLLLSFATPIQFYCGKPLYISAWKTLIYARKCSMDLLVMTSSTIAYFYSLINLILNHFSSLNYNGPIFFETCVILLTLIILGRYLEHLAKSKASNVLVEKMKQLDSSNAILLSNNNNKDVGSEQEIMIEKELIEKGDILKVLPFTKIPTDGIIIRGNGGYIDESIITGEANHVYKRIDDYVFGGTMNQKGCLIIKVTKHSNDTALSNIIKLVEESQSIKPNFQNYADLVASYFVPTILICSIITFIVWFCLIHYNVVIATDNQSAFTFAIKISMSLMVISCPCAISLATPTSIMVGSAIGAKKFGILFKGGGQVIELASKVNKVIFDKTGTLTTGEIDINHFSIYDQSISPKQFFFYTASAELSSEHLIGKSIKQYAIQQFTLEKALQEPTNSEVHPGKGIISFINNNKIMVGNQSFIVEQLSNNNNKIDSCQSPLQSSQLINSKSDDCKKGCCLSLPPPPPPPTSISNGSECKKGCCPAAAAPPISTGNGSDCKKGCCPSLPPPPPTSISNSSDCKKGCCPAPPPTSISNGSDCKKGCCSSSSSQLSKSQSKEVIINSVIQNDIDKLENQGKTVILVSMNEKIIGLVSLSDKLKPEAKKVISKLKNNGIDVWLVSGDNKRATQSIGEQLNINSGNIIGSALPIDKFNIVRKLQGYNTTEDNCCGTDGGDGFNGASVGCSGSDNNSNNGKNKSIVVMVGDGVNDSLALVQSDIGISISNGTDIAIESSSVILLKNDLNDILVCFDLSKSIFKTIKFNLFWAFIYNLLGIPLSSGILYPWFTIPPALAGLSELLSSLPVVLFSLTLNNYKYQNKN
Protein: Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY) (Q6BAA4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15551350, ECO:0000269|PubMed:15676285, ECO:0000269|PubMed:15815692}. Endoplasmic reticulum {ECO:0000305|PubMed:15815692}. Note=Seems not to be secreted. {ECO:0000269|PubMed:15676285}.
Interaction partners:
Sequence:
MWPLTALLLLVPSSGQAATLEKPILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTLWYLGHLLLPSHKKSIEVQTPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAPVFEGEPLVLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRIPVESAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGSPLDPASTTAPAPWAAALAPGNRPLSFRKPPVSRSVPLVTSVRNTTSTGLQFPASGAPTAGPPACAPPTPLEQSAGALKPDVDLLLREMQLLKGLLSRVVLELKEPQALRELRGTPETPTSHFAVSPGTPETTPVES
Protein: Interleukin enhancer binding factor 2 (X6R6Z1)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSE
Protein: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (NDST-1) (N-heparan sulfate sulfotransferase 1) (N-HSST 1) ([Heparan sulfate]-glucosamine N-sulfotransferase 1) (HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 (EC 3.5.1.-); Heparan sulfate N-sulfotransferase 1 (EC 2.8.2.8)] (P52848)
Organism: Homo sapiens (Human)
Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan.
Subcellular location: [Isoform 1]: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:9230113}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:35137078}; Single-pass type II membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:35137078}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Exostosin-2
- Sulfotransferase 1C3
- Sulfotransferase 1C4
- Sulfotransferase 1B1
- Exostosin-1
- Exostosin-like 3
- Heparan sulfate 2-O-sulfotransferase 1
- D-glucuronyl C5-epimerase
- Heparan-sulfate 6-O-sulfotransferase 1
- Treacle protein
Sequence:
MPALACLRRLCRHVSPQAVLFLLFIFCLFSVFISAYYLYGWKRGLEPSADAPEPDCGDPPPVAPSRLLPLKPVQAATPSRTDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIAPGKGDMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCVAYGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLLAKTRSSESIPHLGADAGLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDDIFVGKEGTRMKVEDVKALFDTQNELRAHIPNFTFNLGYSGKFFHTGTNAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWSIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSSELDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFKHLVRFLHSWTNLRLQTLPPVQLAQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYMEFFPIPSNTTSDFYFEKSANYFDSEVAPRRAAALLPKAKVLTILINPADRAYSWYQHQRAHDDPVALKYTFHEVITAGSDASSKLRALQNRCLVPGWYATHIERWLSAYHANQILVLDGKLLRTEPAKVMDMVQKFLGVTNTIDYHKTLAFDPKKGFWCQLLEGGKTKCLGKSKGRKYPEMDLDSRAFLKDYYRDHNIELSKLLYKMGQTLPTWLREDLQNTR
Protein: RNA helicase (EC 3.6.4.13) (DEAD box protein 6) (D3ZD73)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Enhancer of mRNA-decapping protein 3
- CCR4-NOT transcription complex subunit 1
- Protein PAT1 homolog 1
- 5'-
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm1
- Enhancer of mRNA-decapping protein 4
- 5'-
- CCR4-NOT transcription complex subunit 4
- Eukaryotic translation initiation factor 4E nuclear import factor 1
Sequence:
MSTARTENPVIMGLSSQNGQLRGPVKASAGPGGGGPQTQTQMNQLKNTSTINNGTQQQAQSMAATIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPAEDEKP
Protein: Kinesin-like protein KIN-7A (NPK1-activating kinesin-1) (AtNACK1) (Protein HINKEL) (Q8S905)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable plus end-directed motor protein that functions in the NACK-PQR (ANP1-MKK6-MPK4) MAP kinase signaling pathway, which is essential for somatic cell cytokinesis, especially for the cell-plate formation and its expansion. Regulates the activity and the localization of ANP1, probably by association through the non-catalytic region of the kinase. Functionally redundant with NACK2 and essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during microgametogenesis and megagametogenesis.
Subcellular location: Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:23451828, ECO:0000269|PubMed:25502072}.
Interaction partners:
- 65-kDa microtubule-associated protein 3
- Mitogen-activated protein kinase kinase kinase ANP1
- Serine/threonine-protein kinase TIO
- 65-kDa microtubule-associated protein 2
- 65-kDa microtubule-associated protein 1
- Serine/threonine-protein kinase RUNKEL
- Mitogen-activated protein kinase kinase kinase 3
- Mitogen-activated protein kinase kinase 6
- Mitogen-activated protein kinase kinase kinase 2
- Mitotic checkpoint protein BUB3.2
Sequence:
MTIKTPGTPVSKMDRTPAVTPGGSSRSREEKIVVTVRLRPMNKRELLAKDQVAWECVNDHTIVSKPQVQERLHHQSSFTFDKVFGPESLTENVYEDGVKNVALSALMGINATIFAYGQTSSGKTYTMRGVTEKAVNDIYNHIIKTPERDFTIKISGLEIYNENVRDLLNSDSGRALKLLDDPEKGTVVEKLVEETANNDNHLRHLISICEAQRQVGETALNDTSSRSHQIIRLTIQSTHRENSDCVRSYMASLNFVDLAGSERASQSQADGTRLREGCHINLSLMTLTTVIRKLSVGKRSGHIPYRDSKLTRILQHSLGGNARTAIICTLSPALAHVEQSRNTLYFANRAKEVTNNAHVNMVVSDKQLVKHLQKEVARLEAERRTPGPSTEKDFKIQQMEMEIGELRRQRDDAQIQLEELRQKLQGDQQQNKGLNPFESPDPPVRKCLSYSVAVTPSSENKTLNRNERARKTTMRQSMIRQSSTAPFTLMHEIRKLEHLQEQLGEEATKALEVLQKEVACHRLGNQDAAQTIAKLQAEIREMRTVKPSAMLKEVGDVIAPNKSVSANLKEEITRLHSQGSTIANLEEQLESVQKSIDKLVMSLPSNISAGDETPKTKNHHHQSKKKKLLPLTPSSASNRQNFLKSPCSPLSASRQVLDCDAENKAPQENNSSAARGATTPQGSEKETPQKGEESGDVSSREGTPGYRRSSSVNMKKMQQMFQNAAEENVRSIRAYVTELKERVAKLQYQKQLLVCQVLELEANDGAGYSVENEENTIMEDEEQNQVAWHITFIEERQQIIELWHVCHVSIIHRTQFYLLFKGDQADQIYMEVELRRLTWLEQHLAEVGNATPARNCDESVVSLSSSIKALRREREFLAKRVNSRLTPEEREELYMKWDVPLEGKQRKLQFVNKLWTDPYDSRHVQESAEIVAKLVGFCESGNISKEMFELNFAVPSDKRQWNIGWDNISNLLHL
Protein: Hypoxanthine DNA glycosylase (HDG) (EC 3.2.2.-) (Q8TTH3)
Organism: Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Function: Excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Acts on double-stranded DNA containing G/I, T/I, A/I and C/I base pairs, but not on single-stranded inosine-containing DNA. Has also minor xanthine DNA glycosylase activity. Lacks any detectable uracil-DNA glycosylase activity.
Interaction partners:
- DNA-
- Type-4 uracil-DNA glycosylase
- Endonuclease III lyase)
- DNA-
- Endonuclease III lyase)
- Xylose isomerase-like TIM barrel domain-containing protein
- Phosphotransferase
- Methylated-DNA--protein-cysteine methyltransferase
Sequence:
MIKRGFPAVLDENTEILILGSLPSDESIRKQQYYGNPGNDFWRLVGHAIGENLQDMAYEKKLKTLKHNRIGLWDVFKAGSREGSQDSKIGDEEINDFSGLKEMVPKLRLICFNGRKAGEYEPLLRGMGYETKVLPSSSGANRRFSKNRESEWEAVFRH
Protein: Carboxypeptidase inhibitor SmCI (P84875)
Organism: Sabellastarte magnifica (Feather duster)
Function: Potent inhibitor of pancreatic carboxypeptidase A with a Ki of 27 nM, and of the serine proteases trypsin, chymotrypsin and pancreatic elastase, with Ki values of 6.9 nM, 1.83 nM and 4 nM, respectively. Does not inhibit cysteine and aspartic proteases.
Interaction partners:
Sequence:
ISVCDLPADRGQCTAYIPQWFFNKTTEDCEKFVYGGCQGNANRFETKDDCIANCGCNLPSKVGPCRVSARMWFHNPETEKCEVFIYGGCHGNANRFATETECQEVCDRYQKPGFCYQPSETGPCKGSFPRYYYDYEDGECKEFIYGGCEGNANNFETKESCENAC
Protein: Actin-related protein 8 (F-box protein ARP8) (Q9FKT0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:18385164}. Cytoplasm {ECO:0000269|PubMed:18385164}. Note=Localized to the nucleolus in interphase cells and dispersed in the cytoplasm in mitotic cells.
Interaction partners:
- Actin-related protein 5
- Actin-related protein 9
- High mobility group B protein 10
- Actin-related protein 4
- High mobility group B protein 9
- High mobility group B protein 15
- At3g01890
- SWI/SNF complex component SNF12 homolog
- Actin-related protein 2
- Chromatin structure-remodeling complex protein BSH
Sequence:
MILKKVWGSVWNRSNSGKDLVNHQRAIDVPPLLLSSSSSLGAFDQLPMDILVQILMMMEPKDAVKLGLTCKAWKCVASGNRLWIFYLQCSQEPWDSIFFAETSLRSGYPLRMISSQSGELSFMHIYSQRAQVPGSIIIDGGSGYCKFGWSKYASPSGRSATFLEFGNIESPIYARLQQFFATIFTRMQVKPSMQPIVVSLPLCHFDDTESAKASRRQLKTAIFNVLFDMNVPAVCAVNQAVLALYAARRTSGIVVNIGFQVITILPILHGKVMRQVGVEVIGFGALKLTGFLKEKMQENNISFQSLYTVRTLKEKLCYVALDYKAELSKDTQASVEVSGEGWFTLSKERFQTGEILFQPRLAGMRAMSLHQAVSLCMDHCDAAGLTGDDSWFKTVVLTGGSACLPGLSERLERELQDHLPSSISNGIRVIPPPYGVDTSWHGAKLISNLSIFPGPWCITRKQFRRKSRLMW
Protein: Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) (Q9I8C7)
Organism: Gallus gallus (Chicken)
Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli.
Subcellular location: Synaptic cell membrane {ECO:0000250|UniProtKB:Q9JLB5}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9JLB5}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acetylcholine receptor subunit alpha
- RASD family member 2
Sequence:
MGSAPLPACLLALSLAGTVLAPGCGAAQGRLAHKLLHDLFANYSSALRPAEDTERALNVTLQVTLSQIIDMDERNQVLTSYLWVRQAWLDAHLAWDKDAYGGIDSIRIPSSYVWRPDIVLYNNADERFGGSMETNVVLRSDGHIMWDSPAITKSSCKVDVSYFPFDGQQCRLTFGSWTYNGNQIDLRNLLDTGDLTDFVENVEWEVLGMPATRNVVTYGCCSEPYPDVTYTLLLRRRASFYIFNLLLPCVMISFLAPLGFYLPADSGEKVSLGVTVLLALTVFQLLVAESMPPSESVPLIGKYYIATMTMITASTALTIFIMNIHHCGPGARPVPPWARRLILHHLARALCVCEVGESCGRPQREGTGGMGPRDPPGEGVEPGLCPRSRCLCHHHAVLSSVGYIAGVFRRHRTAQRRAAEWKKVAKVMDRFFMWVFFLMVFLMSVLVIGKAA
Protein: Vacuolar protein sorting 38 (Protein UNFLATTENED AND SMALL LEAVES 1) (Q8S9J3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dispensable for autophagy but essential for efficient targeting and degradation of biosynthetic and endocytic cargo to the vacuole. Required for seedling development and plant growth as well as for seed storage proteins (SSPs) vacuolar trafficking. Controls multiple aspects of development by affecting late endosome morphology and by regulating vacuolar and endocytic cargos (e.g PIN1 and PIN2) trafficking and distributions (e.g. polarity), thus influencing auxin transport orientation.
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:29897620}; Peripheral membrane protein {ECO:0000269|PubMed:29897620}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:29897620}; Peripheral membrane protein {ECO:0000269|PubMed:29897620}. Prevacuolar compartment membrane {ECO:0000269|PubMed:29897620}; Peripheral membrane protein {ECO:0000269|PubMed:29897620}. Cytoplasm {ECO:0000269|PubMed:29184027}. Endosome {ECO:0000269|PubMed:29184027}. Note=Colocalizes with and mobilizes VPS29 at late endosomes, probably in a PI3K complex-dependent manner. {ECO:0000269|PubMed:29897620}.
Interaction partners:
Sequence:
MERVSERSLSENLRRSDREDGKIIEWEEFDHELTRLWSLSSAMKLATERKQILQPKLESLIQVSTESLRRTNELEEMRQRLEARKLLVDKTSVACKVTEQDVKKKEENLSTEVRSLLVGGTTLSIAKSKLQESNCQLEGESGYAHLKIVTNKLRKRQQFMVSQVSFIYPLKIEAGPSQDQELESFPGGSRLGTKPLSQGSVRILGLPFSMAPFTKMSFFTDKKEVQKSATALGYVAHAVSLIAPYLRVPIRYPLCLGGSKTYIRDYAPYIEPSPSDMSPITTLSQNINFVEFPLFLDGQDTTRAAYAVFLLNKNIEQLLNFVGENSLGPRQVLANLKELIRIIQSPDYIDYL
Protein: Chromatin modification-related protein EAF6 (ESA1-associated factor 6) (P47128)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
- Chromatin modification-related protein EAF1
- Enhancer of polycomb-like protein 1
- Chromatin modification-related protein YNG2
- Chromatin modification-related protein EAF5
- Protein AF-9 homolog
- Chromatin modification-related protein EAF7
- Histone acetyltransferase ESA1
- Chromatin modification-related protein EAF3
- NuA3 HAT complex component NTO1
Sequence:
MTDELKSYEALKAELKKSLQDRREQEDTFDNLQQEIYDKETEYFSHNSNNNHSGHGGAHGSKSHYSGNIIKGFDTFSKSHHSHADSAFNNNDRIFSLSSATYVKQQHGQSQND