Protein: Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog) (Q8BRH4)
Organism: Mus musculus (Mouse)
Function: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8NEZ4}.
Interaction partners:
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- PAX-interacting protein 1
- Lysine-specific demethylase 6A
- Retinoblastoma-binding protein 5
- Histone-lysine N-methyltransferase 2D
- Nuclear receptor coactivator 6
- WD repeat-containing protein 5
- Protein dpy-30 homolog
- Histone-lysine N-methyltransferase SETD1B
- Lysine-specific demethylase 6B demethylase 6B)
Sequence:
MSSEEDRSAEQQQPPPAPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKSTVEDEDSMDGLETTETENIVETEIKEQSVEEDAETEVDSSKQPVSALQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRVTPGLTLPWKDQPSNKDIDDNSSGTCEKIQNYAPRKQRGQRKERPPQQSAVSCVSVSTQTACEDQAGKLWDELSLVGLPDAIDVQALFDSTGTCWAHHRCVEWSLGICQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHFFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSTQWHHNCLICDTCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDQELDSQLKEDYICMYCKHLGAEIDPLHPGNEVEMPELPTDYASGMEIEGTEDEVVFLEQTVNKDVSDHQCRPGIVPDVQVYTEEPQKSNPLESPDTVGLITSESSDNKMNPDLANEIAHEVDTEKTEMLSKGRHVCEEDQNEDRMEVTENIEVLPHQTIVPQEDLLLSEDSEVASKELSPPKSAPETAAPEALLSPHSERSLSCKEPLLTERVQEEMEQKENSEFSTGCVDFEMTLAVDSCDKDSSCQGDKYVELPAEEESTFSSATDLNKADVSSSSTLCSDLPSCDMLHGYPPAFNSAAGSIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSNHNTVSPPSWAPDTSEGREIFKPRQLSGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGRSKLKSGIGAVVLPGVSAADISSNKDEEENSMHNTVVLFSSSDKFTLQQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCCRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPVSNVPSSDCCDSSLVAQIVTKVKELDPPKTYTQDGVCLTESGMSQLQSLTVTAPRRKRTKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAGDDETKGIEGTDAIKKRKRKPYRPGIGGFMVRQRSRTGQGKAKRSVVRKDSSGSISEQLPSRDDGWREQLPDTLVDEPVSVAENTDKIKKRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQNKLSVDNLSEDAAQLSFKTGFLDPSSDPLLSSSSTSAKPGTQGTADDPLADISEVLNTDDDILGIISDDLAKSVDHSDIGPTTADASSLPQPGVSQSSRPLTEEQLDGILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFTAVLSPATTQPAPLPQPPPPPQLLPMHNQDVFSRMPLMNGLIGPSPHLPHNSLPPGSGLGTFPAIAQSPYTDVRDKSPAFNAIASDPNSSWAPTTPSMEGENDTLSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTTRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSDLFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQQQQQQQQLASQHLLVAPGSDTPSSGAQSPLTPQAGNGNVSPAQTFHKDLFSKHLPGTPASTPSDGVFVKPQPPPPPSTPSRIPVQESLSQSQNSQPPSPQMFSPGSSHSRPPSPVDPYAKMVGTPRPPPGGHSFPRRNSVTPVENCVPLSSVPRPIHMNETSATRPSPARDLCASSMTNSDPYAKPPDTPRPMMTDQFSKPFSLPRSPVISEQSTKGPLTTGTSDHFTKPSPRTDAFQRQRLPDPYAGPSLTPAPLGNGPFKTPLHPPPSQDPYGSVSQTSRRLSVDPYERPALTPRPVDNFSHSQSNDPYSHPPLTPHPAMTESFTHASRAFPQPGTISRSASQDPYSQPPGTPRPLIDSYSQTSGTARSNPDPYSQPPGTPRPNTIDPYSQQPPTPRPSPQTDMFVSSVANQRHTDPYTHHLGPPRPGISVPYSQPPAVPRPRTSEGFTRPSSARPALMPNQDPFLQAAQNRVPGLPGPLIRPPDTCSQTPRPPGPGRIDTFTHASSSAVRDPYDQPPVTPRPHSESFGTSQVVHDLVDRPVPGSEGNFSTSSNLPVSSQGQQFSSVSQLPGPVPTSGGTDTQNTVNMSQADTEKLRQRQKLREIILQQQQQKKIASRQEKGPQDTAVVPHPVPLPHWQPESINQAFTRPPPPYPGSTRSPVIPPLGPRYAVFPKDQRGPYPPEVAGMGMRPHGFRFGFPGAGHGPMPSQDRFHVPQQIQGSGIPPHIRRPMSMEMPRPSNNPPLNNPVGLPQHFPPQGLPVQQHNILGQAFIELRHRAPDGRSRLPFAASPSSVIESPSHPRHGNFLPRPDFPGPRHTDPIRQPSQCLSNQLPVHPNLEQVPPSQQEQGHPAHQSSIVMRPLNHPLSGEFSEAPLSTSTPAETSPDNLEIAGQSSAGLEEKLDSDDPSVKELDVKDLEGVEVKDLDDEDLENLNLDTEDGKGDDLDTLDNLETNDPNLDDLLRSGEFDIIAYTDPELDLGDKKSMFNEELDLNVPIDDKLDNQCASVEPKTRDQGDKTMVLEDKDLPQRKSSVSSEIKTEALSPYSKEEIQSEIKNHDDSRGDADTACSQAASAQTNHSDRGKTALLTTDQDMLEKRCNQENAGPVVSAIQGSTPLPARDVMNSCDITGSTPVLSSLLSNEKCDDSDIRPSGSSPPSLPISPSTHGSSLPPTLIVPPSPLLDNTVNSNVTVVPRINHAFSQGVPVNPGFIQGQSSVNHNLGTGKPTNQTVPLTNQSSTMSGPQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNSLGMPPMVMSRFPFMGPSVAGTQNNDGQTLVPQAVAQDGSITHQISRPNPPNFGPGFVNDSQRKQYEEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQQSMVQKQLEQIRKQQKEHAELIEDYRIKQQQQQQQCALAPPILMPGVQPQPPLVPGATSLTMSQPNFPMVPQQLQHQQHTAVISGHTSPARMPSLPGWQSNSASAHLPLNPPRIQPPIAQLSLKTCTPAPGTVSSANPQNGPPPRVEFDDNNPFSESFQERERKERLREQQERQRVQLMQEVDRQRALQQRMEMEQHCLMGAELANRTPVSQMPFYGSDRPCDFLQPPRPLQQSPQHQQQIGPVLQQQNVQQGSVNSPPNQTFMQTNEQRQVGPPSFVPDSPSASGGSPNFHSVKPGHGNLPGSSFQQSPLRPPFTPILPGTSPVANSNVPCGQDPAVTQGQNYSGSSQSLIQLYSDIIPEEKGKKKRTRKKKKDDDAESGKAPSTPHSDCAAPLTPGLSETTSTPAVSSPSELPQQRQQEPVEPVPVPTPNVSAGQPCIESENKLPNSEFIKETSNQQTHVNAEADKPSVETPNKTEEIKLEKAETQPSQEDTKVEEKTGNKIKDIVAGPVSSIQCPSHPVGTPTTKGDTGNELLKHLLKNKKASSLLTQKPEGTLSSDESSTKDGKLIEKQSPAEGLQTLGAQMQGGFGGGNSQLPKTDGASENKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSSDSFTHLKQQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVARALGPKPFQLPFRPQDDLLARAIAQGPKTVDVPASLPTPPHNNHEELRIQDHYGDRDTPDSFVPSSSPESVVGVEVNKYPDLSLVKEEPPEPVPSPIIPILPSISGKNSESRRNDIKTEPGTLFFTSPFGSSPNGPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSNAPDVPPMGLVSSHRVNPSLEYRQHLLLRGPPPGSANPPRLATSYRLKQPNVPFPPTSNGLSGYKDSSHGPAEGASLRPQWCCHCKVVILGSGVRKSCKDLTFVNKGSRENTKRMEKDIVFCSNNCFILYSSAAQAKNSDNKESLPSLPQSPMKEPSKAFHQYSNNISTLDVHCLPQFQEKVSPPASPPISFPPAFEAAKVESKPDELKVTVKLKPRLRTVPVGLEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTCLKPDPVPKDCRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCATKAQCMFFKDKTMLCPMHKPKGIHEQQLSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDSSPKDVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRRMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSNRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN