wanglab/gogpt-training-data huggingface dataset:
Protein: Pyruvate kinase PKLR (EC 2.7.1.40) (L-PK) (Pyruvate kinase isozymes L/R) (P12928)
Organism: Rattus norvegicus (Rat)
Function: Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis.
Interaction partners:
- Alpha-enolase
- Enolase 4
- L-lactate dehydrogenase A chain
- Beta-enolase
- L-lactate dehydrogenase C chain
- Glucose-6-phosphate isomerase
- Gamma-enolase
- L-lactate dehydrogenase B chain
- Phosphoenolpyruvate carboxykinase, cytosolic
- Pyruvate carboxylase, mitochondrial
Sequence:
MSVQENTLPQQLWPWIFRSQKDLAKSALSGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSQPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLSYRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSVS
Protein: Copine 1 (A6PVH9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGDGKWHLVYRSEVIKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLLLTDGAVTDVEATREAVAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPAQAPQA
Protein: Dolichol phosphate-mannose biosynthesis regulatory protein (Q38ET7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365084}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365084}.
Interaction partners:
- PhosphatidylinositolN-acetylglucosaminyltransferase subunit c, putative
- phosphatidylinositol N-acetylglucosaminyltransferase
- PIG-P domain-containing protein
- Dolichol-phosphate mannosyltransferase subunit 1
- Glycosyltransferase, putative
- Alpha-1,3-mannosyltransferase, putative
- N-acetylglucosaminylphosphatidylinositol deacetylase
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
- Phosphatidic acid phosphatase, putative
- mannose-1-phosphate guanylyltransferase
Sequence:
MCLRACTQERNLCRIPCASWMLYLLFLLTFMCPLPICNQATNLTEELNLLHCSDWFVYAYALRDMLYDRSIARVFLVLTTLLYVYYVVWIGVTPFIVSSHFTQNFFPPREYGIFVAAAVMTLMLGVTVTLASVRTILWAGAVGPEESG
Protein: AT4G32605 protein (Mitochondrial glycoprotein family protein) (Q8L7K1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MWRRVIGNVAVRHQLQRALSSKAGGSGKSANVSAAVDSMLLRSLKEHYLEVSKMTPPPKVSPPSPFEIVKGSLEGSTGAVLKKSVGNEEINLFVMRLAHGGDEEDDGGINQLFLHVAVSKPNQPDSLHFLCGLYPDALGIHSVSMRPKLEALEMSDDPTQYTGPSFEELDEKMRDVFHGFLEERGVNESLFPFLQAWLYVKDHRNLLRWFKSVGTFVHENPSAENTA
Protein: Large ribosomal subunit protein uL1m (39S ribosomal protein L1, mitochondrial) (L1mt) (MRP-L1) (A6QPQ5)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16510155}.
Interaction partners:
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL11m
- Large ribosomal subunit protein uL4m
- Ribosomal protein
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein uL13m
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein bL20m
- Large ribosomal subunit protein uL29m
Sequence:
MAATVRCFGRVLIHHQRCSLATVTSQTSLYPCCIYVPVPNRHFAAAAKPAKKTKKGTKEKASNEKKDDIEKIKSYPFMEGEPEDDVYLKRLYPRQIYEVEKAVNLLKKFQVLDFTNPKQGVYLDLTLDMTLGKKKKVEPFASVLSLPYPFISEMSKVAVFTGNASEIKIAEENGAAFAGGTNLIQKILDDEIQADFYIAVPEIMPELNPLRKKLKTRFPKFNRNSVGRDIPKMLELFKTGLEIKVDEERENFLETKIATLDMPSDQIAANLQAVINEVCRQRPLNLGPFVVRAFLRSSTSEGLLLKIEPLLPKEGETKESDKKAV
Protein: GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) (O13774)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
Interaction partners:
- Folic acid synthesis protein fol1
- Uncharacterized protein C30D11.11
- Vacuolar protein sorting-associated protein vts1
- Probable GTP cyclohydrolase-2
- Inosine triphosphate pyrophosphatase
- ADIPOR-like receptor SPBC12C2.09c
- Alkaline phosphatase
- Nucleoside diphosphate kinase
- Pyruvate kinase
- Reticulon-like protein 1
Sequence:
MEPGKKDYIDSPLRMQPASLSGASTPTIDLDGLSWPCQGTQRRIDTAEEEKVKKISNAISTILECLGEDPERQGLLGTPERYAKAMLYFTKGYEQNLTEVINEAVFQEDHEEMVIVRDIDVFSLCEHHLVPFIGKIHIGYIPRKRVLGLSKLARIANMFSRRLQVQERLTKQVAQAIQAVLKPQGVAVVMEATHMCMVMRGVEKPGSSTVTSSLTGIFQRSHKTREEFFRLIGKF
Protein: Kelch-like protein diablo (Q9VK21)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- FI08017p
- LD15807p)
- Regulatory protein zeste
- Stretchin-Mlck, isoform U
- GH13213p
- DNA polymerase zeta subunit 2
- Cullin 3, isoform F
- Protein asteroid
Sequence:
MPPLKTYQIHEYNGNTSPNANANQNANQNPTGGGGDGDFFGQNLGSGATAASHRTNLPSYCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFDVLSHVRMALVPVKVIDKALKDDCRDMSVKIALRSICRDIASKRGQLVPLRVCPRQLAKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGAVVV
Protein: Probable acrylyl-CoA reductase AcuI (EC 1.3.1.84) (Acryloyl-coenzyme A reductase AcuI) (P26646)
Organism: Escherichia coli (strain K12)
Function: Probably catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Propionate--CoA ligase
- Fatty acid oxidation complex subunit alpha
- Fatty acid oxidation complex subunit alpha
- Phosphate acetyltransferase
- Acetyl-coenzyme A synthetase
- 2-methylcitrate synthase
- Methylmalonyl-CoA decarboxylase
- 2,3-dehydroadipyl-CoA hydratase
- PFL-like enzyme TdcE
- Formate acetyltransferase 1
Sequence:
MQALLLEQQDGKTLASVQTLDESRLPEGDVTVDVHWSSLNYKDALAITGKGKIIRNFPMIPGIDFAGTVRTSEDPRFHAGQEVLLTGWGVGENHWGGLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVMALEDAGVRPQDGEIVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYLKSLGASRVLPRDEFAESRPLEKQVWAGAIDTVGDKVLAKVLAQMNYGGCVAACGLAGGFTLPTTVMPFILRNVRLQGVDSVMTPPERRAQAWQRLVADLPESFYTQAAKEISLSEAPNFAEAIINNQIQGRTLVKVN
Protein: Blue-sensitive opsin (Blue cone photoreceptor pigment) (P32310)
Organism: Carassius auratus (Goldfish)
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MKQVPEFHEDFYIPIPLDINNLSAYSPFLVPQDHLGNQGIFMAMSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYILVNLSIANLFVAIFGSPLSFYSFFNRYFIFGATACKIEGFLATLGGMVGLWSLAVVAFERWLVICKPLGNFTFKTPHAIAGCILPWISALAASLPPLFGWSRYIPEGLQCSCGPDWYTTNNKYNNESYVMFLFCFCFAVPFGTIVFCYGQLLITLKLAAKAQADSASTQKAEREVTKMVVVMVLGFLVCWAPYASFSLWIVSHRGEEFDLRMATIPSCLSKASTVYNPVIYVLMNKQFRSCMMKMVCGKNIEEDEASTSSQVTQVSSVAPEK
Protein: Protein spaetzle 5 (Neurotrophic factor 2) (Protein spatzle 5) (Q9VZX1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Neurotrophin which may function as a ligand for the Toll-related receptors Toll-6 and Toll-7. Binds to Toll-7 and Toll-6, and probably acts as their ligands in the promotion of motor axon targeting and neuronal survival in the central nervous system (CNS). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons. May be involved in the normal development of specific neurons at the neuromuscular junction.
Interaction partners:
- Toll-like receptor 7
- Toll-like receptor 6
- Toll-9, isoform A
- RE45222p
- Protein spaetzle 4
Sequence:
MTKSIKRPPPFSCKQVLLTYVILAYTVAAHSSPPPCGLYGAPPCQFLPAPPGQTPTCARPGKTYCEHADNYPTYLIKSLVRKWGYEAATLLVDETWEDFAAVAWHDTPVFYDPKSIFPPRDPAAQDFNGYSYQTPFGGNPQRPSGGGNPLFVSNPSTEAPTYLLYTSSGGGHRSGHRYNSQGGGTSSSGGHLYINQSDKSTPYNATLWLKRLVRDLSRKQRQPDEVQAEVVEPVNEQTEEAEEQDNPAEDHPQSKRDVSLNMDLLDIVGVEAPNPLKKRSRTKRQSPGRSTLCQTTSQFITPQAALNSRGNWMFVVNEQNTARQMVKAELCASNTCSNLCELPNGYNSRCEQKFVQKRLIALQGNGQNLYTDTFWFPSCCVCTIAAN
Protein: Cdc42-interacting protein 4, isoform B (A8JNK4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- RE12101p
- Cdc42 homolog
- AT02057p
- WHAMM and JMY related, isoform B
- Amphiphysin
- Protein diaphanous
- Dynamin
- Dishevelled associated activator of morphogenesis, isoform D
- LD35927p
- Syndapin, isoform C
Sequence:
MLKKKLAQITKKKTVADLEAECVHSAIAFTCVRVCAKLLASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKKKEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVERYKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNSTSNHLTIRGTMSANKLKKRVGIFNIFGSNKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEITLYA
Protein: Probable UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (O94617)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Phosphoacetylglucosamine mutase 1
- Phosphoacetylglucosamine mutase 2
- Chitin synthase 1
- Probable glutamine--fructose-6-phosphate aminotransferase
- Glucosamine 6-phosphate N-acetyltransferase
- Chitin synthase-like protein 2
- Protein transport protein sec23-2
- Protein transport protein sec23-1
- Phosphoglucomutase
- Arginyl-tRNA--protein transferase 1
Sequence:
MDDKELFDRSIFEETNQLHLYDQLNYLKKNDLQKFRKLLNQVQQLDLRSLWLKYRNAKATSQENRKLSPSEVGPLSIVDTSDSSWWRTGLREIARGHVAALVLAGGQGTRLGFAGPKGCFRLGLPNNPSIFELQAQKIKKSLALARAAFPDQEASISIPWYIMVSECTSEETISFFKENDFFGIDKKDVFFFQQGVLPCLDISGRVLFESDSSLAWAPNGNGGIYEALLSSGALNDMNRRGILHITAYSVDNVLVLPVDPVFIGMATTKKLEVATKTVEKIDPAEKVGLLVSSHNHPCVVEYSEISDEACKATENVDGHKHLLLRAANIAYHYFSFDFLQKASLHSSTLPIHLACKKIPFYDVTSHHYTTPLNPNGYKLESFIFDLFPSVSVENFGCFQVPRRTSFSPLKNSSKSPNDNHETCVNDILSLGKSWILKNGGILSPSDCTYVSPECSLQGESLEWIKGKQVSNCKLY
Protein: Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Q71KK5)
Organism: Sus scrofa (Pig)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000369}.
Interaction partners:
Sequence:
MFVNRWLYSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNQAWAKIHFVIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTAWNTISSMGSFISLTAVMLMIFIIWEAFASKREVSAVELTSTNLEWLHGCPPPYHTFEEPTYINLK
Protein: Protein ver-1 (Vascular endothelial growth factor receptor related 1) (G5ED65)
Organism: Caenorhabditis elegans
Function: Involved in amphid glia remodeling during entry into dauer stage by promoting the fusion of sheath amphid cells which encloses AWC neuron sensory endings. May be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Protein let-756
- Sex muscle abnormal protein 5
- Platelet-derived growth factor
- Zinc finger protein ztf-16
- Protein ver-2
- Homeobox protein ttx-1
- Serpentine Receptor, class Z
- Cell fusion protein aff-1
- Bromodomain adjacent to zinc finger domain protein 2
Sequence:
MTHRTPNFRRFHLFLPLFLKGMIFLLLHFKFLVIFALELPIISLRPKSDCFLFWKCTTDYRIQKNQKIGKFVELTEGQTLSLQCAYRRGTPKFTYPNFLAERVEQEFSEPLNTDYVRIEDIRESDTGSFSCNSTENPAQSDSIHVFVHKSKIFLPSKSVFSKKDLWNELTVPCKTTKLTESKEIELYADGKLVASQDFDPRHGFRITRKGYAAQPSFFECKFNKKNKTQSVDFIISKNEPIDNEYILFWEDSFPFPHVGYNFSLTCHLVYIEPNGNAPKLGELAFECPQCQSRLDNHLVIEKHHNVGRKRLSSAIHIKNLQLRDAGKYRCIWKKTGKARQEIEHSLHVSPTIAQVRILEQSPSFLKAKAGSGSVKLYAKFAVYPAGNYTVTWRRTYNSIEGPRDEIVEKGLSATFLENSESMEVLDITDLSCNKSGKYLLSINYQDTSETIFWEVAVESDYPDVQLIIREPASFKVFGHQFYLLGTHLNIDCVSTSIPLVDALLEYRKENFKIFTKVSRSFVADGTFERKISYQVVLTENMMLKCRVGNRVALETVHVADEIPNIKFKLASNKSAIYEGDTVKLTCVVPKLAGRCSITWVHRNLSILHSTEVTEHSQLSFLYIRNATTSASGNYTCVLENQASENFSLSTILKVEPIIAPYIVKTGFSAPTGSKLDCNIDGRPPPEYQWFKDGTPYGTGRRLKFFEEDNSGIYQCLATNRAGSATNSFELKTAGRSYGIFVLLAILALGILVILGWKISTKLGWKKNRDLKLLYKSLIGSENFLPNGKNQFSNFNFEFHKDSLEILEPIGSGHFGVVRRGILKGTKTVVAVKSSSYRSSIGFQKVIVEELKLMSAIPKHPNVLALVGAITKNLRHGELYILMEYIDGGNLRDFLQQRRNVFIDELHDNFDENIPLIRPDFNSLSTTDLVGIAHQIANGMEWLGNVPCVHGNLCCRKVLISKTKTIRITDYGVGDRQRKSSSMRWMAPEAIEHQMFSSKSDVWSFGICLYEIFTLGGTPYPTCVTENILKHIKNGSRNLQPEYCPSALYDLMQLCWRAPPQDRPKFSLCSELIEKQLKDLTISF
Protein: INO80 complex subunit C (Q8BHA0)
Organism: Mus musculus (Mouse)
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Actin-related protein 5
- RuvB-like 2
- RuvB-like 1
- Actin-related protein 8
- INO80 complex subunit E
- INO80 complex subunit B
- Chromatin-remodeling ATPase INO80
- Actin-like protein 6A
- INO80 complex subunit D
- Microspherule protein 1
Sequence:
MAAQIPIVAATSTPAVARNSKKRPASPSHNSSGGGYGASKKKKLSASGFAQGVSIEAMNESKMASSELSSGPVEKAAKPLPFKDPNFVHSGHGGAVAGKKNRTWKNLKQILAAERALPWQLNDPNYFSIDAPPSFKPAKKYSDISGLLANYTDPQSKLRFSTVEEFSYIRRLPSDVVTGYLALRKATSIVP
Protein: Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8) (Q9H228)
Organism: Homo sapiens (Human)
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-12
- Sphingosine kinase 1
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Sphingosine kinase 2
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Natural killer cells antigen CD94
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
Protein: Mevalonate kinase (MK) (MvK) (EC 2.7.1.36) (Ergosterol biosynthesis protein 12) (Regulation of autonomous replication protein 1) (P07277)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. ERG12 converts mevalonate into 5-phosphomevalonate. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:1645230}.
Interaction partners:
- Diphosphomevalonate decarboxylase
- Phosphomevalonate kinase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
- LAS seventeen-binding protein 3
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
- Acetyl-CoA acetyltransferase
- Hydroxymethylglutaryl-CoA synthase
- Isopentenyl-diphosphate delta-isomerase
- Farnesyl pyrophosphate synthase
- Squalene synthase ERG9
Sequence:
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTTTKQQIDDLLLPGNTNLPWTS
Protein: alcohol dehydrogenase (EC 1.1.1.1) (Q6FQA4)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- S-
- alcohol dehydrogenase
- Pyruvate decarboxylase
- Candida glabrata strain CBS138 chromosome G complete sequence
- Candida glabrata strain CBS138 chromosome L complete sequence
- Candida glabrata strain CBS138 chromosome D complete sequence
- Candida glabrata strain CBS138 chromosome H complete sequence
- Aldehyde dehydrogenase
- Candida glabrata strain CBS138 chromosome F complete sequence
- Aldehyde dehydrogenase 5
Sequence:
MATLHAVPETQKGVIFYENNGKLEYKDIPVPKPKANEILINVKYSGVCHTDLHAWHGDWPLATKLPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMACEYCEKSNESNCPEADLSGYTHDGSFQQYATADYVQAARIPQGTDLAQVAPILCAGITVYKALKSANLNAGEWVAISGAAGGLGSLAVQYAKAMGYRILGIDGGDEKKALFHELGGEIFVDFTKSKNVEQDILVATNGGAHGVINVSVSEAAIESSTRYVRSNGTVVLVGLPANAKCSSDVFNHVVKSISIVGSYVGNRADTREALDFFSRGLVKSPIKIAGLSELPEIYEKMEKGQIVGRYVVDTSK
Protein: Protein sprouty homolog 1 (Spry-1) (Q9QXV9)
Organism: Mus musculus (Mouse)
Function: Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
Interaction partners:
- Growth factor receptor-bound protein 2
- Son of sevenless homolog 1
- E3 ubiquitin-protein ligase CBL
Sequence:
MDSPSQHGSHTSLVVIQPPAVEGRQRLDYDRDTQPATILSLDQIKAIRGSNEYTEGPSVARRPAPRTAPRPEKQERTHEIIPANVNSSYEHRPASHPGNARGSVLSRSTSTGSAASSGSSSSVSSEQGLLGRSPPTRPIPGHRSDRVIRTQPKQLLVEDLKASLKEDPTQHKFICEQCGKCKCGECTAPRALPSCLACDRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDDGGSYSDNPCSCSQSHCCSRYLCMGALSLCLPCLLCYPPAKGCLKLCRGCYDWTHRPGCRCRNSNTVYCKLESCPSRAQGKLS
Protein: Large ribosomal subunit protein uL1A (60S ribosomal protein L1-A) (L10a) (O14363)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS19B
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein eL33A
- Small ribosomal subunit protein eS28A
- Large ribosomal subunit protein uL23A
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS28B
Sequence:
MSKVSPANIRSSVETILKGSEEKKRNFTETVELQIGLKNYDPQRDKRFSGTIKLPNVPRPNMSICILGDAHDLDRAKHGGVDAMSVDDLKKLNKNKKLVKKLAKKYDAFIASEVLIKQIPRLLGPGLSKAGKFPSPVSHSDDLYGKIIEVKSTIKFQLKKVLCLGVAVGHVDMAEEQLAANLSLAINFLVSLLKKGWQNIGSLVIKSTMGKPYRLY
Protein: E3 ubiquitin-protein ligase SopA (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SopA) (Salmonella outer protein A) (Secreted effector protein SopA) (Q8ZNR3)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Required for inducing polymorphonuclear leukocytes migration across the intestinal epithelium. Preferentially uses host UBE2D1 (UBCH5A), UBE2D2 (UBCH5B) and UBE2L3 (UBCH7) as E2 ubiquitin-conjugating enzymes.
Subcellular location: Secreted {ECO:0000269|PubMed:16547027}. Host cell {ECO:0000269|PubMed:16547027}. Note=Secreted via type III secretion system 1 (SPI-1 T3SS), and delivered into the host cell. Can also be secreted through the flagellar export apparatus. {ECO:0000269|PubMed:16547027}.
Interaction partners:
- Guanine nucleotide exchange factor sopE2
- Cell invasion protein SipA
- Inositol phosphate phosphatase SopB
- Secreted effector protein SopD
- SPI-1 type 3 secretion system translocon protein SctE
- Cell invasion protein SipD
- Secreted effector protein SptP
- E3 ubiquitin-protein ligase SlrP
- Secreted effector protein sopD2
- E3 ubiquitin-protein ligase SspH2
Sequence:
MKISSGAINFSTIPNQVKKLITSIREHTKNGLTSKITSVKNTHTSLNEKFKTGKDSPIEFALPQKIKDFFQPKDKNTLNKTLITVKNIKDTNNAGKKNISAEDVSKMNAAFMRKHIANQTCDYNYRMTGAAPLPGGVSVSANNRPTVSEGRTPPVSPSLSLQATSSPSSPADWAKKLTDAVLRQKAGETLTAADRDFSNADFRNITFSKILPPSFMERDGDIIKGFNFSNSKFTYSDISHLHFDECRFTYSTLSDVVCSNTKFSNSDMNEVFLQYSITTQQQPSFIDTTLKNTLIRHKANLSGVILNEPDNSSPPSVSGGGNFIRLGDIWLQMPLLWTENAVDGFLNHEHNNGKSILMTIDSLPDKYSQEKVQAMEDLVKSLRGGRLTEACIRPVESSLVSVLAHPPYTQSALISEWLGPVQERFFAHQCQTYNDVPLPAPDTYYQQRILPVLLDSFDRNSAAMTTHSGLFNQVILHCMTGVDCTDGTRQKAAALYEQYLAHPAVSPHIHNGLFGNYDGSPDWTTRAADNFLLLSSQDSDTAMMLSTDTLLTMLNPTPDTAWDNFYLLRAGENVSTAQISPVELFRHDFPVFLAAFNQQATQRRFGELIDIILSTEEHGELNQQFLAATNQKHSTVKLIDDASVSRLATIFDPLLPEGKLSPAHYQHILSAYHLTDATPQKQAETLFCLSTAFARYSSSAIFGTEHDSPPALRGYAEALMQKAWELSPAIFPSSEQFTEWSDRFHGLHGAFTCTSVVADSMQRHARKYFPSVLSSILPLAWA