wanglab/gogpt-training-data huggingface dataset:
Protein: Zeta tubulin (Q4GZA3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Tubulin alpha chain
- Nucleoside diphosphate kinase-like domain-containing protein
- Kinesin, putative
- Tubulin-specific chaperone A
- TOG domain-containing protein
- Calponin-homology
- End-binding protein 1
- Kinesin-like protein, putative
- Ankyrin repeat protein
- Cilia- and flagella-associated protein 45
Sequence:
MAIVVVQVGQCGNQLGEELWRQLSIATDKGAVRSPFFTSNRKARCVMVDSEPKVVQTVYNRYADIMRAENVVCGHSGRGNHWALGYYGLNNPKSSRCAEKAAASRPFQVTKDQRRGDNFVVRDALRAIYAETRRTDDTEEFEAILVLHSLAGGTGSGMASLLLEKIRYYFIEPTEDELANADEKAEADMMWNDGLDGMLMHKRRALFLISIAVAPQSIGEISTQSLNAALTLHALRIVDAVLLLRNDDCLRARDDRAAGPRGAGGKETISSSSSLSLLKPCATFTEVNEVFVTLLMPVLLYGVGESPICNLVLSCSPSHRKMNNILTIVPTPQRHYLRFKESSILSRFYCITGAKSHLPSVCPTVPVELLHTSRSLQSTDPVHSREEVKIPKPLYLSFVQPGSKKRSPAATLLTEIEGVLVMNQARELNAQLLFPLLRTAAVKVKAGAFMSTFLDSGVAAERIQLAIKSVALKLADAEED
Protein: Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) (P67049)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00008}.
Interaction partners:
Sequence:
MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI
Protein: MamK-like protein (EC 3.6.1.-) (Magnetosome cytoskeleton protein MamK-like) (P0DSO6)
Organism: Paramagnetospirillum magneticum (strain ATCC 700264 / AMB-1) (Magnetospirillum magneticum)
Function: Protein with ATPase activity which forms pole-to-pole filaments in vivo, probably with MamK. Efficient filament formation requires MamK. Probably promotes turnover of MamK filaments, by providing a monomer pool. In vivo, in the absence of its paralog MamK, forms thin filaments from pole to pole. In vitro forms straight filaments and bundles in the absence of ATP. Filament formation is triggered by KCl and MgCl(2); polymerizes more slowly and makes thinner filaments than MamK. Expression in E.coli yields a filament in the cell's longitudinal axis; the protein nucleates at one pole or the cell septum.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:20161777, ECO:0000305|PubMed:24957623}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20161777, ECO:0000269|PubMed:24957623}. Note=Protein forms filaments extending along most of the cell associated with its inner curvature, in the correct position to be filaments that are seen associated with magnetosomes (PubMed:20161777). Colocalizes in filaments with paralog MamK (PubMed:24957623). {ECO:0000269|PubMed:20161777, ECO:0000269|PubMed:24957623}.
Interaction partners:
Sequence:
MIVNDNQNILYVGIDFGYSKTVIMTSRGKSLSLKSLVGYPKDFVGLARLGRPYLVGDEAFEMRSYLHLRNPLLDGLLNPISEQDIDVTRHFISHIIKCAEPAAGEKVFAVIGVTPRFTAANKKLLLKLAQEYCQNVLLMSAPFLAGNSIGKASGSIIIDIGAWTTDICAMKGRIPRPEDQSSIAKAGSYIDERLKNSILERYPALQINANIARMVKEQFAFVGRPQLVAACEFRSAGKAVRCDVTEQVRAACESPFAEIAERIGAVLCVVPPEDQALVLKNIVITGAGAQIRGLPEYVKSMLAPYGDARVSIANEPLMEACKGALSMAQEIPPHFWGQL
Protein: TBC1 domain family member 8B (B0R0W9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in vesicular recycling, probably as a GTPase-activating protein for Rab family protein(s).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q0IIM8}.
Interaction partners:
- GTPase-activating protein and VPS9 domains 1.
- Ankyrin repeat and FYVE domain-containing 1
Sequence:
MWLKPEEVLLKNALKLWVTEKSNDYFVLQRRRGYGEDSGGLTGLLVGTLDTVLDSTAKVAPFRILHQTPDSQVYWTIACGASLEEISQHWDWLQQNIVRTLSVFDSGEDITSFVQGKIRGLIAEEGTSAGDEEDPERFREAVLRFERLFGLPQREKLVTYFSCSYWRGRVPNQGWIYLSTNFLCFYSYMLGNEVKLVYPWDEVSRLERTSSVLLAESIRVRVRGEDHFFSMLLRLQQTYLIMQQLADYAIVRFFDKETFHAEHPLANPLHITQRALEIHARNQSFRSFFRLPQEENLCEVYESFLWVPFSHVNTLGKICVSENYLCFASQDGSQCHLIIPLWEVFSVELPDRSSRALTVCLRGKRALRFSEVRDFERLAATIRRKCGTLGSPQHCITNPDEEGVMVGQSQAVSTEALMNVFHPHDAENLDPKMLKERMKEQSWQIHFAEYGRGTGMFCTKKTRDLIVRGVPETLRGELWMLFSGAVHDMISHPGYYGRLLEDCMGSSSLACDEIERDLHRSLPEHPAFQSDTGISALRRVLTAYAHRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIREHLTQLTEHMTDLSFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAVLDYNMDNLLCCNDDAEAVTVLNRFFDSVTNKDSPLPATVQQASATANDKSIQKVDISDLIKEAYEKYGDIRTEEVENMRKRNKLYVIQTLEDTTKQNVLRVVAQDVKFSASQLDELYLLFKNHDPSLPYLDQYQLDQSQFSSLFNLLQPWTTHTHSRSLARSAFHLLDENGDGLVNFKEFICGLDILYNRSFTEKLKLLFKLHLQPDSAEDGVIRKCPERGRAKVDLQEYLKQWQEDLQRREENIKDLPRINQVQFISLTKTLYSVFHGDEEEESLYRAVARVTSLLLRMEEVGRKLQDSSPQKTPQTTPTSTSQPESSPTKPTSPESETPAESRSTHDQPESPVSQHETAPSHSDITPNSTSHPSTPTSSPTETSSPVLDTPTDTPSSPCTVRDGDWSFSFEQILASLLNEPSVVRFFERVVNTDTLITRARKNQLKDAH
Protein: Receptor protein-tyrosine kinase (EC 2.7.10.1) (Q153D9)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MPVGHVSLERIFVFISTRMCPAGRLVCPGWLSVLWALGTLQAACGQSVCAGTDNKLSSLSDLEQQYKALRKYYENCEVVMGNLEITSIEHGRNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRGIKLYEDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQNKFLCYADTIHWQDIVRTPNATLVPMASNAECGRCPKSCMGRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSDCCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRACPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGSLQSAQTVDSSNIDKFVNCTKINGNLHFLVTGIDGDPYHNIAALDPQKLNIFSTVREITGFLNIQSWPKNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYITDNPNLCYYHTVNWTSLFRTSNQRTTIRENKKSENCTAEGMVCDPFCSNIGCWGPGANQCLSCRYFSRGKSCVRSCNLCKGESREFANGSVCVKCDPQCEKIDEGMATCYGAGPDHCTKCSSFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDGCRGPRLKDCIGIIDRTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRIKILGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPNPNDSKFFKNLLNEEDLGDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRNQFVYRDGGYTTQEAVNLPFRPTACPITEVPTAQGATAEVFDDVCCNGTLRKQISERIPEESSLQRYSADPTAFVPERNPRGVVGEDGYMTPIKEKPKSDYLNPVEENPFVSRRKNGDVQAVEKPEYNNGTSTQSKSEDEYVKERLYLNSFAKSKENAEYLKNNGLTVPEKSKKAFDNPEYWNHSLPPRSTIHHPDYLHEYSTKYFYKQNGRIRPVVAENPEYLTEFTLKPGTVLPPPPYRHRNTVV
Protein: Trihelix transcription factor PTL (Trihelix DNA-binding protein PETAL LOSS) (Q9LZS0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that prevents growth. Regulates perianth architecture in flower, mostly in the second whorl, probably by suppressing growth between initiating sepals, ensuring that they remain separate, and by modulating organ shapes. Required for the establishment of auxin flux.
Subcellular location: Nucleus.
Interaction partners:
- B3 domain-containing protein REM2
- AT-hook motif nuclear-localized protein 11
- Transcription factor IND
Sequence:
MDQDQHPQYGIPELRQLMKGGGRTTTTTPSTSSHFPSDFFGFNLAPVQPPPHRLHQFTTDQDMGFLPRGIHGLGGGSSTAGNNSNLNASTSGGGVGFSGFLDGGGFGSGVGGDGGGTGRWPRQETLTLLEIRSRLDHKFKEANQKGPLWDEVSRIMSEEHGYQRSGKKCREKFENLYKYYRKTKEGKAGRQDGKHYRFFRQLEALYGDSNNLVSCPNHNTQFMSSALHGFHTQNPMNVTTTTSNIHNVDSVHGFHQSLSLSNNYNSSELELMTSSSEGNDSSSRRKKRSWKAKIKEFIDTNMKRLIERQDVWLEKLTKVIEDKEEQRMMKEEEWRKIEAARIDKEHLFWAKERARMEARDVAVIEALQYLTGKPLIKPLCSSPEERTNGNNEIRNNSETQNENGSDQTMTNNVCVKGSSSCWGEQEILKLMEIRTSMDSTFQEILGGCSDEFLWEEIAAKLIQLGFDQRSALLCKEKWEWISNGMRKEKKQINKKRKDNSSSCGVYYPRNEENPIYNNRESGYNDNDPHQINEQGNVGSSTSNANANANVTTGNPSGAMAASTNCFPFFMGDGDQNLWESYGLRLSKEENQ
Protein: DNA-directed RNA polymerase subunit (A0A384LJI7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005586}.
Interaction partners:
Sequence:
MEFCPTCGNLLRYEGGGNSRFFCSTCPYVAYIQRQVEIKKKQLLVKKSIEAVVTKDDIPTAAETEAPCPRCGHDKAYFKSMQIRSADEPESRFYRCLKCEFTWREE
Protein: Neuroglian (P20241)
Organism: Drosophila melanogaster (Fruit fly)
Function: The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20935638}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, septate junction {ECO:0000269|PubMed:20935638}.
Interaction partners:
- Neurexin-4
- Contactin
- Ankyrin, isoform B
- Sodium/potassium-transporting ATPase subunit alpha
- Sinuous
- Ankyrin 2, isoform U
- Fasciclin-3
- Sodium/potassium-transporting ATPase subunit beta-2
- Protein elav
- Fasciclin-2
Sequence:
MWRQSTILAALLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTATSNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLAKFRINWLPSTEGHPGTHFFTMHRIKGETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIMVANETVANAGWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEGGFHEYSQPLDNKSAGRQSVSSANKPGVESDTDSMAEYGDGDTGQFTEDGSFIGQYVPGKLQPPVSPQPLNNSAAAHQAAPTAGGSGAAGSAAAAGASGGASSAGGAAASNGGAAAGAVATYV
Protein: Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) (Q8BJI1)
Organism: Mus musculus (Mouse)
Function: Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P31662}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31662}. Postsynapse {ECO:0000269|PubMed:25704603}. Presynapse {ECO:0000269|PubMed:25704603}. Note=Localizes at synaptic junctions - at both pre- and post-synaptic sites - particularly in excitatory glutamatergic terminals. {ECO:0000269|PubMed:25704603}.
Interaction partners:
Sequence:
MPKNSKVTQREHSNEHVTESVADLLALEEPVDYKQSVLNVAGETGGKQKVAEEELDTEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGWSVFYFFKSFQYPLPWSECPVIRNGTVAVVEPECEKSSATTYFWYREALDISNSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHVNFSHLTTKDYSEMYSVIMTVKEKQFPALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFFVGLLFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFQPYRFYFYMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWIKEEAAERYLYFPNWAMALLITLIAVATLPIPVVFILRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLDNSNNPNGRYGSGYLLASTPESEL
Protein: LOC729862 protein (Q0VAF8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAVASTKSRWETGEVQAQSAAKTLSCKDIVAGDMSNKSFWEQKGGSKTSSTIKAQIAFLQGEGKGQENLKKDLVRMIKMLEYALKQKRAKYHKLKYGTELNQGAMKPPSYDSDEGNEIEVQPQQNSQLM
Protein: Grainyhead-like protein 3 homolog (Transcription factor CP2-like 4) (Q5FWH3)
Organism: Mus musculus (Mouse)
Function: Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. Essential for epidermal differentiation and barrier formation at the end of embryogenesis with TGM3 as critical direct target. Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Also required for proper development of the oral periderm. No genetic interaction with GRHL1, no functional cooperativity due to diverse target gene selectivity.
Subcellular location: Nucleus {ECO:0000269|PubMed:21081122}.
Interaction partners:
- Interferon regulatory factor 6
- Zinc finger protein 750
Sequence:
MSNELDFRSVRLLKNDPVSFQKFPYSNEDEAWKTYLENPLTAATKAMMRVNGDEESVAALSFLYDYYMGPKEKRILSSSTGGRNDQGKKFYHSMDYEPDLAPLESPTHLMKFLTENVSGSPDYTDQLKKNNLLGLEGVLPTPGKTNTVPPGPSKLEASSMDSYLLPASDIYDNGSLNSLFESIHGVPPTQRWQPDSTFKDDPQESLLFPDILKTSPDPPCPEDYPGLKSDFEYTLGSPKAIHIKAGESPMAYLNKGQFYPVTLRTPAGGKGLALSSSKVKSVVMVVFDNDKVPVEQLRFWRHWHSRQPTAKQRVIDVADCKENFNTVQHIEEVAYNALSFVWNVNEEAKVFIGVNCLSTDFSSQKGVKGVPLNLQIDTYDCGAGTERLVHRAVCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNNAGIKGCLLSGFRGNETTYLRPETDLETQPVLFIPNLHFSSLQRPGGVVPSAGHSSSDRLPLKRTCSPFAEEFEPLPSKQAKEDDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGLPEENICKVYKKCKRGILVNMDNNIIQHYSNHVAFLLDMGELDGKIQIILKEL
Protein: Beta-fructofuranosidase, insoluble isoenzyme CWINV4 (EC 3.2.1.26) (Beta-fructofuranosidase 6) (AtFruct6) (Cell wall beta-fructosidase 4) (Cell wall invertase 4) (AtcwINV4) (Sucrose hydrolase 4) (Q8W413)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}. Secreted, cell wall {ECO:0000305}. Note=Associated to the cell wall. {ECO:0000305}.
Interaction partners:
- alpha-D-xyloside xylohydrolase
- Probable galactinol--sucrose galactosyltransferase 4
- Probable fructokinase-5
- Probable fructokinase-4
- Probable fructokinase-3
- Probable fructokinase-7
- Probable fructokinase-6, chloroplastic
- Probable fructokinase-2
- Probable fructokinase-1
- Probable hexokinase-like 2 protein
Sequence:
MAISNVISVLLLLLVLINLSNQNIKGIDAFHQIYEELQSESVESVNHLHRPSFHFQPPKHWINDPNGPVYYKGLYHLFYQYNTKGAVWGNIIWAHSVSKDLVNWEALEPALSPSKWFDIGGTWSGSITIVPGKGPIILYTGVNQNETQLQNYAIPEDPSDPYLRKWIKPDDNPIAIPDYTMNGSAFRDPTTAWFSKDGHWRTVVGSKRKRRGIAYIYRSRDFKHWVKAKHPVHSKQSTGMWECPDFFPVSLTDFRNGLDLDYVGPNTKHVLKVSLDITRYEYYTLGKYDLKKDRYIPDGNTPDGWEGLRFDYGNFYASKTFFDYKKNRRILWGWANESDTVEDDILKGWAGLQVIPRTVLLDSSKKQLVFWPVEEIESLRGNYVRMNNHDIKMGQRIEVKGITPAQADVEVTFYVGSLEKAEIFDPSFTWKPLELCNIKGSNVRGGVGPFGLITLATPDLEEYTPVFFRVFNDTKTHKPKVLMCSDARPSSLKQDTGLLAKDRMYKPSFAGFVDVDMADGRISLRSLIDHSVVESFGALGKTVITSRVYPVKAVKENAHLYVFNNGTQTVTIESLNAWNMDRPLQMNDGAL
Protein: MACPF domain-containing protein NSL1 (Protein NECROTIC SPOTTED LESIONS 1) (Protein NSL1) (Q9SGN6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Negatively controls the salicylic acid (SA)-mediated pathway of programmed cell death in plant immunity.
Interaction partners:
- Probable L-type lectin-domain containing receptor kinase S.7
- Probable LRR receptor-like serine/threonine-protein kinase At4g37250
- AT5g23340/MKD15_20
- At4g27652
- Expressed protein
- At4g27654
- At1g66080
- GEM-like protein 6
Sequence:
MAFNNFTRLDAHSAAEKAVSVIGLGYDLCSDVRFSACKTTPDGSRLVEIDPTRNRDLIFPGGIVVNNVSSSIKCDKGERTRLRSDILSFNQMSEKFNQDMCLSGKIPSGMFNNMFAFSKCWPKDASSVKTLAYDGWFISLYSVEIVRKQLTLRDEVKREVPSSWDSAALAGFIEKYGTHVVVGVTMGGKDVIHVKQMRKSNHEPEEIQKMLKHWGDERFCVDPVESKSPASVYSGKPKEENLLQWGLQPFGTSVSSAVVMHTKNEEIMRVCIRRGGVDLGQSHERWLSTVSQAPNVISMCFVPITSLLSGLPGTGFLSHAVNLYLRYKPPIEELHQFLEFQLPRQWAPVYGDLPLGLRRSKQSSPSLQFSLMGPKLYVNTSKVDSGERPVTGLRFFLEGKKGNHLAIHLQHLSACPPSLHLSHDDTYEPIEEPVEKGYYVPVKWGIFSHVCTYPVQYNGARSDDTASIVTKAWLEVKGMGMRKVLFLRLGFSLDASAVTRKSCWDNLSTNSRKSGVFSMISTRLSTGLSPNPATTKPQSKIDINSAVYPRGPSPPVKPKLLSLVDTKEVMRGPEEQPGYWVVTGAKLCVEAGKISIKAKYSLLTVISEDSLV
Protein: Zinc finger protein rotund (Zinc finger protein roughened eye) (Q9VI93)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transcription factor involved in imaginal disks development. Isoform rn is required in the wings, antenna, haltere, proboscis and legs disks, while isoform roe is required in the eye disk. Together with nab corepressor, it is involved in the initiation and maintenance of wingless (wg) expression in the wing hinge, by limiting the expression of wg to this compartment. Also required for the epithelial-mesenchymal transition branch of basolateral junctions signaling.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MIMHGTWYKGPQLAHHPHSNPHNSSHGHSDYHQFRSYPSFVVTPYHDGHVQGPATPTPCTAPPTPCNGPVPVSVPVSIPVCHTGGQGSPVIVESSFAIAAAAAAAAAAVAVGGSSATPLLPSPPIKIEQVFGEPSSLGAVVEDYALGLDCPVEHTFRKPHNNNGYSWSTGNNNEVVSHSSNGHTNNHPTTPPTPPNEASATQATSVSAINLNQAQPASQTRSNFGSSIKSPPSEPDAVTAATCKSQENNSGQNPTPNSLSDHNPAHNLNSNSTAAAVAAAAAAAAAANMPIGGVQGQNPTQGLVHWMSAVMAEHMTGQTHHDPGAVGMHYMWNGNVDHAKDISDYNLWPPTPRSHQHASEHHPMSLKQEYEAKMNDHHHNNLQKGHFLDDNRLEHHAVTGQGGLGLGASNGVGGGGGGASVVGNSSLGASSHHAVAAAHHHNQAVAAASAAALLVVPQPINASKMGGPGGVSSVAGGHATGGGSGRKYQCKMCPQIFSSKADLQLHTQIHMREAKPYKCTQCSKAFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHPGCQKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEPSLLEHIPKHKESKHLKTHICQYCGKSYTQETYLTKHMQKHAERTDKRPPIVPGSAAAIAAAAAAAAGGSANPANGPPPPPNPAQHQRNNLGLPPVSIAPSDNGYWPKVSPDSAAAANAMEVMHQQQQQQQQQQQQQQQQQQQQQQQAHHHHPQHGVPPQQHVPPQQQQQQQQQQQHHHPQQQPPPQHSMEAHYAQPTAPNGSQSNGHGAELQPHHRMPDPVREDIASTPSAVGPYDAASITKTTSNSAFTPINSMPPHLNSLSHHPMAQRPYLYDAISFPNKNVNQNNANAFPNQLISLHQIRNYAHQPAGLMAGEHLLGVSVGPGKDKG
Protein: Transmembrane protein (Q2F988)
Organism: Oryza sativa subsp. indica (Rice)
Interaction partners:
Sequence:
MHDDPIIILLILLILVFVSRMLVRALWPRSAVLTSRIFTTFVVLSSAVLSGSVAHAADNEPINNGAAPAAYGSGAEGPSNSALFTYTSDLAEDSVSSGRSRSTASSSFQESTGEMDALMASTTPSAPRTPSGGEPSVNQPLPGEQAMPPALPVMQEAANRALPYAPYPYPVDEIIGGDCVQSIQRRILGANLNPSAHDMQMSRIQAEDLFELKVQIIRKMATLHPSGDWMGWGARALDNPRTATGEEDLAKLHKMLDDLQSRNEQSATFWRLVERVRLRADEDQNSAS
Protein: Clarkitoxin-I-Mdum (Dumertoxin-1) (C0HLK5)
Organism: Micrurus dumerilii (Coral snake)
Function: No toxicity is observed upon intravenous or intracerebroventricular injection into mice. Has no cytotoxic activity towards C2C12 cells at 100 ug/ml.
Subcellular location: Secreted {ECO:0000269|PubMed:31557485}.
Interaction partners:
Sequence:
RICDDSSIPFLRTPQLCPKGQDVCYKKTPIVKKFKWLQKKGCASSCPKDGFIKIFKIECCTKDNCI
Protein: Nucleolar protein 58 (Q59S06)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for pre-18S rRNA processing. May bind microtubules (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
- Utp5p
- Rrp9p
- Utp9p
- Utp13p
- SnoRNA-binding rRNA-processing protein
- rRNA-processing protein
- Nan1p
- Nucleolar protein 56
- 13 kDa ribonucleoprotein-associated protein
- RNA cytidine acetyltransferase
Sequence:
MAYVLTETAAGYALLKAADKKIHKSSSLVEDLNTAEKVAEQFKIHRFEKFQSAANALEEANAIIEGKVSENLQKLLEDAKSDKKATLIVSEAKLGNAINKLGLNFQVVSDAASLDLQRAIKQFLPELLPGLDDSALKQMSLGLAHSMGRHKLKFSADKVDTMIIQAIALLDDLDKELNTYAMRCKEWYGWHFPELAKMITDSAAYARIILTMGVRSNASETDLSEILPEEVEEQVKAAAEVSMGTEITEDDLNNIKALAEQIVDFAAYREQLSNYLSSRMKAIAPNLTAMVGELVGARLIAHAGSLTSLAKAPASTVQILGAEKALFRALKTKHDTPKYGIIYHASLVGQASGKNKGRIARTLAAKAAVSLRYDCFDEERDESDDFGLENRAKVEGRLSQLEGRDMRTTSKVVREQPKVEITEARAYNADADSTAAAAAAAPTADSDDEESETEEVEEKKSKKDKKKDKKEKKDKKKDKKRKRDDDKEDKESSKKSKKDKKEKKEKKEKKAKKEKK
Protein: Chromatin accessibility complex protein 1 (CHRAC-1) (DNA polymerase epsilon subunit p15) (NF-YC-like protein) (YC-like protein 1) (YCL1) (Q9JKP8)
Organism: Mus musculus (Mouse)
Function: Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA polymerase epsilon subunit 3
- Bromodomain adjacent to zinc finger domain protein 1A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1
- Nuclear transcription factor Y subunit beta
- Nuclear transcription factor Y subunit alpha
- Tyrosine-protein kinase BAZ1B
- Trafficking protein particle complex subunit 9
- Remodeling and spacing factor 1
- Bromodomain adjacent to zinc finger domain protein 2A
Sequence:
MADAAVGKEKCGDQRLVSLPLSRIRVIMKSSPEVSSINQEALVLTAKATELFVQYLATCSYRHGSGKAKKALTYSDLASTAEDSETLQFLADILPKKILASKYLKMLKEKREEEEDNEDDGSDLGEALA
Protein: Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) (Q96AC1)
Organism: Homo sapiens (Human)
Function: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
Subcellular location: Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.
Interaction partners:
- Filamin-binding LIM protein 1
- Scaffold protein ILK
- Paxillin
- Vinculin
- Alpha-parvin
- LIM and senescent cell antigen-like-containing domain protein 1
- Filamin-A
- Phosphatidylinositol-binding clathrin assembly protein
- Fermitin family homolog 3
- Integrin beta-1
Sequence:
MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLTSGWV