wanglab/gogpt-training-data huggingface dataset:
Protein: Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) (Q804C3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
MLRLVQRVRPSARLTRPSVLSGPAAAPAASPRPGPVSCHHLKRYHSSGPARIRSSFHGRRVCNSILSNRSWGLRSQTAAFSQSMRVYSLPPHQKVELPALSPTMQMGTIARWEKKEGDKINEGDLIAEVETDKATVGFEMLEECYLAKILVAEGTRDVPIGAVICITVDKPELISSFKDFTLDKITSSAPAAAAPPPPATPTSAPAAPQVPGSSYPPHMKVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKIMISEGTRDVPLGTPLCIIVEKESDISAFADYVETGVAASPPPAPTLVATPPPAAAPAAPIPAPAAAPAAPAAARKGRVFASPLAKKLAAEKGVDITQVTGTGPDGRVTKKDIDSFVPPKLTPAAAAAPSAPTPSPPAAPAYAAVPTGTFTDVPISNIRKVIAQRLMQSKQTIPHYYLSIDVNMDQVLELRKELNAEVKAENIKLSVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPVGLITPIVFNAHIKGLANISKDVSALAAKARDGKLQPHEFQGGTFTISNLGMYGIKHFSAIINPPQACILAVGGSEKRLLPADNEKGFDVANMMSVTLSCDHRVVDGAVGAQWLAEFRKFLEKPFTMLL
Protein: Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) (Q68CP4)
Organism: Homo sapiens (Human)
Function: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:17897319}. Note=Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain.
Interaction partners:
- Alpha-N-acetylglucosaminidase
- N-sulphoglucosamine sulphohydrolase
- N-acetyltransferase ESCO1
- N-acetyltransferase ESCO2
- N-acetylglucosamine-6-sulfatase
Sequence:
MTGARASAAEQRRAGRSGQARAAERAAGMSGAGRALAALLLAASVLSAALLAPGGSSGRDAQAAPPRDLDKKRHAELKMDQALLLIHNELLWTNLTVYWKSECCYHCLFQVLVNVPQSPKAGKPSAAAASVSTQHGSILQLNDTLEEKEVCRLEYRFGEFGNYSLLVKNIHNGVSEIACDLAVNEDPVDSNLPVSIAFLIGLAVIIVISFLRLLLSLDDFNNWISKAISSRETDRLINSELGSPSRTDPLDGDVQPATWRLSALPPRLRSVDTFRGIALILMVFVNYGGGKYWYFKHASWNGLTVADLVFPWFVFIMGSSIFLSMTSILQRGCSKFRLLGKIAWRSFLLICIGIIIVNPNYCLGPLSWDKVRIPGVLQRLGVTYFVVAVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGDDHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWSLSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRKKIFWKI
Protein: RE51676p (Q7YU50)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQQAIPTLPTQSDIDKAMQPHSAQNMYVSTGNNNSGNTRSNPQSGGIFRGPPSTPNAPRGASGGATRHVHVQPMYSQPLHQNMVLQQYTQYNPRQQTFPASHLQYAPAPMPYYQYQYVPTLQQQPPHTRSAVTVNTNVNVGNNLQPVQSGPNGPLPVPGASSSQIQLLTSTVQPGASTVMGVGGPGSTMGQVGVPPMVGVGVMTTSVQPQPVQVQPASRRRHQHRLQIIDPTTKKNILDDFDKTKSNTDNEFSDQVTSTNTPATVLSEGPIRIPQQESVGLNNLTSTSSQGSESRTNAPYIPIETTPISRTDVGPTPIVSAMTDAPSVEILPTPQRGRSKKIPIVSPKNVSESIVAPITDETDDAGSTPISRATEESMPPNQTHPNLLISDSSKHKQAVSNSEISKDAPTGLKEMHVAELESSVASENHPAGILDVNVNKSSQSLDFSADPEIDSIGAISPTSPNAVSPILHEVLDNTELSKKLENSTTERFKDSQSVEKPTHQELSLRNATDETEISAMALQDVNSLDNNQIEKTYPSKPKLNVDVSEDISSRESAIKSTSTKNTGVDVGLQSDSKPETTLNDKQDSTDLKVKVSAKISSIINYNEGQWSPNNPSGKKQYDREQLLQLREVKASRIQPEVKNVSILPQPNLMPSFIRNNNNNKRVQSMVGIIGNRSNESAGNYIGKQMSMSGVQSGGGRSSMKGMIHVNLSLNQDVKLSENENAWRPRVLNKSDGDSDAKSALEKDELVRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVIDERMESETKSNSAHFRNALLDKTEQEFTQNVSQSTAKEKNYSQLWIKLRNVLMPMKKRNLRHFWKKKKEK
Protein: Ras association domain-containing protein 1 homolog (Q22744)
Organism: Caenorhabditis elegans
Function: Involved in embryonic morphogenesis. Plays a role in the organization of apical filamentous actin in epithelial cells of the developing embryo. May play a role in let-60-mediated vulval development. May induce nuclear condensation. Positively regulates the oxidative stress response, and this may be in association with the small GTPase rab-39. Not required for muscle integrity.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9NS23}.
Interaction partners:
- Connector enhancer of kinase suppressor of ras
- Serine/threonine-protein kinase cst-1
- Serine/threonine-protein kinase cst-1
- Nitrogen permease regulator 2
- Protein salvador homolog 1
Sequence:
MLRSVVNNNDKAKESEQSVRVATDDPTYQSYAFQPSTSSSNISWFGGLRTKLSQLSLFPDWMSQLGIKSDDEKMETSSTSSPQSEQSIGEYDESTLVFRPVQLDHFGGAGQEDDGEQVDIWDFGATFLADLDSNHVWNDTIERQHFGPLKDLITTGGGANKINNHSFKTHSLLHPTWCDKCGDFIWGILKEALKCEHCNYTCHARCRDLVTLDCRSPGSSLASSTEFDSIYPQLDGTLGTIPKGLILPPAMSSSTGSDKENGNGNSAGISAENPIFSVKNSFTLPKSFSPVDSLRTKEPSAPPESRYATLRVVERYVKEDTPFEWTDEYKEMDLERKIHSYNSLAKGMEITLHEDGVNFGGHIHVNMNLSRPISVVQGVIPPTVYDVVNTAKSTAKTTSLRTITSFFLPRNTAKVINIDSKTTARKMIVTLLKKFRVADNPRKFALYECEQITDEATCTLNRKLTRISDDACPLKVVLNWQSPHCGRALVLQENDTGDILWDAFEIPELENFLRILGMEEKQYVFQTQQKYQQYRYHLDAELRQRGHSVPDAAAQPMVQTNPFLDEEFLRNQDEYGTSDSMLFSGTIKNAIMGEDPDYVNLEYLKKQNMDQSTNL
Protein: Plasmodesmata-located protein 3 (PD-located protein 3) (Cysteine-rich repeat secretory protein 11) (O22784)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates cell-to-cell trafficking.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8GXV7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8GXV7}. Cell junction, plasmodesma {ECO:0000269|PubMed:18215111, ECO:0000269|PubMed:20886105, ECO:0000269|PubMed:25393742}. Note=Co-localizes with the Grapevine fanleaf virus (GFLV) 2B-MP at the base of tubules within modified plasmodesmata.
Interaction partners:
- Probable cysteine-rich repeat secretory protein 6
- Protein At-4/1
- Protein EFFECTOR OF TRANSCRIPTION 2
- PLASMODESMATA CALLOSE-BINDING PROTEIN 1
- Probable pectinesterase/pectinesterase inhibitor 19
- Microtubule-associated protein RP/EB family member 1A
Sequence:
MGFYSLKQLLLLYIIIMALFSDLKLAKSSSPEYTNLIYKGCARQRLSDPSGLYSQALSAMYGLLVTQSTKTRFYKTTTGTTSQTSVTGLFQCRGDLSNNDCYNCVSRLPVLSGKLCGKTIAARVQLSGCYLLYEISGFAQISGMELLFKTCGKNNVAGTGFEQRRDTAFGVMQNGVVQGHGFYATTYESVYVLGQCEGDIGDSDCSGCIKNALQRAQVECGSSISGQIYLHKCFVGYSFYPNGVPKRSSPYPSSGSSGSSSSSSSSGTTGKTVAIIVGGTAGVGFLVICLLFVKNLMKKKYDDY
Protein: Large ribosomal subunit protein uL4 (60S ribosomal protein L4) (L1) (P09180)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ubiquitin-ribosomal protein eS31 fusion protein
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein eL34
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL39
- FI01658p
Sequence:
MSLGNARPLVSVYTEKNEPAKDKNICLPAVFKAPIRPDVVNEVHQLLRRNNRQAYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTFRRWHRKVNVNQRRYALVSAIAASGVPALVQSKGHVIDGVSEFPLVVSDEVQKVQKTKQAVIFLRRLKIWADIQKVYKSQRFRAGRGTMRDRRRIARRGPLVVYDKDEGLRKAFRNIPGIETINVDKLNLLKLAPGGHVGRFVIWTESAFARLNDLFGTWKKPSTLKKGYNLPQPKMANTDLSRLLKSEEIRKVLRDPRKRVFRSVRRLNPLTNVRQLIKLNPYAEVLKRRAALAAEKRTVAKVLAKAKKQNVELAKSHFANVATKAAANRAKLLAARKKKVAAKKPAAKK
Protein: F-box/kelch-repeat protein SKIP11 (SKP1-interacting partner 11) (Q8L736)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MLEDRSPDSCLSTRVFSSSRLSESNWSNSYMYPEDDDKLLGNGKRALEVVGEVRQTKSLKLMGFSIIYDSDSSDYSLSGGEEQADAAIGDGSSSRQEQEQQSDFNDNGGDSSDSHSLINEIGRDNSIDCLIRCSRSDYGSIASLNRNFRSLVKSGEIYRLRRQNGFVEHWVYFSCQLLEWVAFDPVERRWMQLPTMPSSVTFMCADKESLAVGTDLLVLGKDDFSSHVIYRYSLLTNSWSSGMKMNSPRCLFGSASLGEIAIFAGGCDSQGKILDFAEMYNSELQTWITLPRMNKPRKMCSGVFMDGKFYVIGGIGGADSKGLTCGEEYDLETKKWTQIPDLSPPRSRADQADMSPAAEAPPLVAVVNNQLYAADHADMEVRKYDKENKKWLTVGRLPERAGSVNGWGLAFRACGERLIVIGGPKCSGGGFIELNSWIPSDGGPPQWTLLDRKHSPTFVYNCAVMGC
Protein: Large ribosomal subunit protein mL63 (Mitochondrial ribosomal protein 63) (Mitochondrial ribosomal protein L57) (Ribosomal protein 63, mitochondrial) (bMRP63) (Q3ZC04)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11402041}.
Interaction partners:
- Large ribosomal subunit protein mL52
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein mL49
- Large ribosomal subunit protein mL50
- Large ribosomal subunit protein mL52
- Large ribosomal subunit protein mL62
- Large ribosomal subunit protein mL54
- Aurora kinase A interacting protein 1.
- Coiled-coil-helix-coiled-coil-helix domain containing 1
- Small ribosomal subunit protein mS34
Sequence:
MFLTALLCRGRIPGRQWIGKHRRPRTVSALAKQNMIRRLEIEAENHYWLSRPFLTAEQERGHAAARRAAAFEALKAAQAAKFPAHRRLEDQLDHLNVTRKWS
Protein: Putative intelectin (Q9DFE0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MTSPGLPGHRLHPQSTHSPGTTLGTKKPQENFTDPTQETSFFITFRPINNELAAMAICSGVKPTTGGDTEHYCIGGGGHFPEGAPRQCGDFPAFDWNGYGTNTEWSASKQLTEAAVLLFYR
Protein: Ribonucleoprotein PTB-binding 2 (Protein raver-2) (Q9HCJ3)
Organism: Homo sapiens (Human)
Function: May bind single-stranded nucleic acids.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=May shuttle between the nucleus and the cytoplasm. {ECO:0000250}.
Interaction partners:
- Heterogeneous nuclear ribonucleoprotein D-like
- Polypyrimidine tract-binding protein 1
Sequence:
MAAAAGDGGGEGGAGLGSAAGLGPGPGLRGQGPSAEAHEGAPDPMPAALHPEEVAARLQRMQRELSNRRKILVKNLPQDSNCQEVHDLLKDYDLKYCYVDRNKRTAFVTLLNGEQAQNAIQMFHQYSFRGKDLIVQLQPTDALLCITNVPISFTSEEFEELVRAYGNIERCFLVYSEVTGHSKGYGFVEYMKKDFAAKARLELLGRQLGASALFAQWMDVNLLASELIHSKCLCIDKLPSDYRDSEELLQIFSSVHKPVFCQLAQDEGSYVGGFAVVEYSTAEQAEEVQQAADGMTIKGSKVQVSFCAPGAPGRSTLAALIAAQRVMHSNQKGLLPEPNPVQIMKSLNNPAMLQVLLQPQLCGRAVKPAVLGTPHSLPHLMNPSISPAFLHLNKAHQSSVMGNTSNLFLQNLSHIPLAQQQLMKFENIHTNNKPGLLGEPPAVVLQTALGIGSVLPLKKELGHHHGEAHKTSSLIPTQTTITAGMGMLPFFPNQHIAGQAGPGHSNTQEKQPATVGMAEGNFSGSQPYLQSFPNLAAGSLLVGHHKQQQSQPKGTEISSGAASKNQTSLLGEPPKEIRLSKNPYLNLASVLPSVCLSSPASKTTLHKTGIASSILDAISQGSESQHALEKCIAYSPPFGDYAQVSSLRNEKRGSSYLISAPEGGSVECVDQHSQGTGAYYMETYLKKKRVY
Protein: BRCA1-associated RING domain protein 1 (AtBARD1) (Protein REPRESSOR OF WUSCHEL 1) (F4I443)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds specifically to H3K4me3 regions of target genes (e.g. WUS and WOX5) promoters to repress their transcription via chromatin remodeling. Required for the shoot apical meristem (SAM) organization and maintenance, by confining WUS expression to the organizing center, and for the quiescent center (QC) development in the root apical meristem (RAM), by repressing WOX5 expression in the root proximal meristem. Plays a role in DNA repair and in cell-cycle control. Required for the repair of DNA double-strand breaks (DSBs), both natural and induced by genotoxic stress, by homologous recombination (HR).
Subcellular location: Nucleus {ECO:0000269|PubMed:16957774, ECO:0000305|PubMed:18591352}.
Interaction partners:
- Nibrin homolog
- Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A
- Protein BREAST CANCER SUSCEPTIBILITY 1 homolog
- DNA repair protein RAD50
- Protein BREAST CANCER SUSCEPTIBILITY 2 homolog B
- Double-strand break repair protein MRE11
- DNA repair protein RAD51 homolog 1
- Cleavage stimulation factor subunit 50
- Mov34/MPN/PAD-1 family protein
- Serine/threonine-protein kinase ATR
Sequence:
MAEFTNMLMNPWVLHLQKLELELKCPLCLKLLNRPVLLPCDHVFCDSCVHKSSQVESGCPVCKSKHPKKARRDLRFMESVISIYKSLNAAVSVHLPQLQIPNDCNYKNDALNNSNSPKHGESEDSEMTDKDVSKRSGGTDSSSRDGSPLPTSEESDPRPKHQDWTEKQLSDHLLLYEFESEYDAANHTPESYTEQAAKNVRDITASEQPSNAARKRICGDSFIQESSPNPKTQDPTLLRLMESLRSDDPTDYVKAQNHQQLPKSHTEQDSKRKRDITASDAMENHLKVPKRENNLMQKSADIDCNGKCSANSDDQLSEKISKALEQTSSNITICGFCQSARVSEATGEMLHYSRGRPVDGDDIFRSNVIHVHSACIEWAPQVYYEGDTVKNLKAELARGMKIKCTKCSLKGAALGCFVKSCRRSYHVPCAREISRCRWDYEDFLLLCPAHSSVKFPNEKSGHRVSRAEPLPKINPAELCSLEQTPAFTKELVLCGSALSKSDKKLMESLAVRFNATISRYWNPSVTHVIASTDEKGACTRTLKVLMGILNGKWIINAAWMKASLKASQPVDEEPFEIQIDTQGCQDGPKTARLRAETNKPKLFEGLKFYFFGDFYKGYKEDLQNLVKVAGGTILNTEDELGAESSNNVNDQRSSSIVVYNIDPPHGCALGEEVTIIWQRANDAEALASQTGSRLVGHTWVLESIAGYKLHPVIG
Protein: GH01724p (p47) (Q7K3Z3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Transitional endoplasmic reticulum ATPase TER94
- UBX domain-containing protein 6
- GM09977p
- Phospholipase A2 activator protein, isoform A
- Ubiquitin thioesterase Otu1
- UBX domain-containing protein 4
- Small VCP interacting protein, isoform A
- Derlin-1
- Ubiquitin fusion degradation protein 1 homolog
- Uncharacterized protein
Sequence:
MAARGDLIAQFIEITGTDENVARFYLSSCDWDIEHALGNYWSTQADLPVPVPTVGHADNPKPKPTSSSGASASASAAGATKSADSAVATSSASVDIAPAATKAKPKFATLSDMSKESSSDDDQQAFYAGGSDRSGQQVLGPPKRKNFREQLTDMMRSAQEQNIAEVGPSTSSGSASGGSGGAVWGQGMRLGMTDNDHTAVGTKKPAATIENKPVVVLKLWSQGFSIDGGELRHYDDPQNKEFLETVMRGEIPQELLEMGRMVNVDVEDHRHEDFKRQPVPQTFKGSGQKLGSPVANLVTEAPTVPVALSPGEAANQEASARDAINLNSEAPSTTLQIRLADGSRLAAQFNLSHTVSDIRRFIQTARPQYSTSNFILVSSFPTRELSDDNSTIEKAGLKNAALMQRLK
Protein: MAGUK family (Q95XW5)
Organism: Caenorhabditis elegans
Interaction partners:
- Trifunctional purine biosynthetic protein adenosine-3
- Adenine phosphoribosyltransferase
- Cell division control protein 42 homolog
- PDZ domain-containing protein
Sequence:
MPDNLSAIFGTILDYAEEVAAGTSNENDERPPRTSLTKKQQKAVSILRNFSTNDQKQEISFQELSQNVLDDWDISNIKSSSVQQLVELLNLPRVQGVLWAAQEISAGRFAPQLPDVPFEVDEDDGVAVKIVRIVRRGEPLGATIKCERGKVYVARIMANGVADRSGCIQEGDRVLEVNGITVADKEPREIVKLLDKCDNGIITFKLIPAEINQKLKQKKSSHRYARALFDYDPWQDKRHPCPEAAISFRGGDILEILDEKDQYWWQTRKIGFGALARRKESHDDENRDDSKKVGLVPSEWLQCQSEIPENGIDTSDDFQSFLENHKGRFYESVFRWRNKKKRRRVVVLLGAPGVGRNEIRRQFFKVFADRFTNAIPHTSRPQRPNESDGVNYYFTSRSEMERMIERKEMLEYGEFRDNLYGTALKSVRKASEKGTVLLTPHPLAIENIRTWEFAPIVIFVQPPEFGEFKHTREVYRSQTTRSHSAASSSNISQNTAATSAARAFSDVEIRQIIDNSAQMEQKYRGYCDAIIRNVDLDTTMNELTGLIYQLESKATWMPMKWLDDIGE
Protein: Wtf element wtf14 (A0A482ASA5)
Organism: Schizosaccharomyces kambucha (Fission yeast)
Function: May act in meiotic drive.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255, ECO:0000269|PubMed:32032353}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the endoplasmic reticulum in both vegetative cells and in spores. {ECO:0000269|PubMed:32032353}.
Interaction partners:
Sequence:
MENNHHLAKDSLDELNPKRGKGEHETQVSQYTVVEEATIPQSLVKTSRSADHKVMEASKVADTRTAWSTKIPAVLLPVFVINIALFKYLVFANFSTKDRVLFGLGNGGINIFSMWLLLATYETWFRSIKEVIVACGAGIRSFPQKRGVNMLYAILKLTFVNAFAIPLLMFFRSHFEQWRLGCPLVERVIGVMLNVAYFIIEIENPGLFTRVFNKYCDCLFAIRDILNRN
Protein: Uncharacterized protein (A0A060W1Y7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- steroid 11beta-monooxygenase
- 3 beta-hydroxysteroid dehydrogenase
- Testosterone 17-beta-dehydrogenase 3
- Testosterone 17-beta-dehydrogenase 3
- aromatase
- Carrier domain-containing protein
- Cytochrome P450 3A
- (3R)-3-hydroxyacyl-CoA dehydrogenase (17-beta-hydroxysteroid dehydrogenase 8) (Estradiol 17-beta-dehydrogenase 8) (Testosterone 17-beta-dehydrogenase 8)
- Cholesterol 7-alpha-monooxygenase
- 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein
Sequence:
MAWFLCMCVFSVVGLGLLLLQVKLRRSLETRGGPPSLPVFPLIGSLLSLRSNQAPHVLFQKLQQKYGHTYSLMMGPHTVILVNHHQHAKEVLLKKGKIFAGRPRTVTTDLLTRDGKDIAFADYGATWRFHRKTVHGALCMFGEGSASIEKIICREALSLCDTLRESGSASLDLSPELTRAVTNVVCSLCFSSSYCRGDPEFEAMLQFSQGIVDTVAKDSLVDIFPWLQVFPNADLRLLKQCVSIRDKLLQKKYEEHKSDYSDHEQRDLLDALLRAKRSAENNNTAEITMETVGLSEDHLLMTVGDIFGAGVETTSTVLKWAIAYLIHHPQVQQRIQEELDSVVGGDRTPQLSDRGSLPYLEATIREVLRIRPVAPLLIPHVAQTDTSIGKFTVRKGARIIINLWSLHHDEKEWKNPEMFDPGRFLNEEGTGLCIPSPSYLPFGAGVRVCLGEALAKMEIFLFLSWILQRLTMTVSPGQPLPSLEGKFGVVLQPVKYQVNATPRAGWEKSHLQTS
Protein: ADP-ribosylation factor-like protein 1 (Arf-like GTPase 1) (P38116)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Recruits golgins such as IMH1 to the Golgi. Can bind and hydrolyze GTP. May be involved in trafficking events within the endosomal system.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:12620188, ECO:0000269|PubMed:12620189}.
Interaction partners:
- ADP-ribosylation factor guanine nucleotide-exchange factor SEC7
- ARF guanine-nucleotide exchange factor 2
- ADP-ribosylation factor GTPase-activating protein GCS1
- Golgin IMH1
- ARF guanine-nucleotide exchange factor 1
- GTP-binding protein YPT6
- Protein MON2
- ADP-ribosylation factor GTPase-activating protein GLO3
- Guanine-nucleotide exchange factor YEL1
- Arf guanine nucleotide exchange factor SYT1
Sequence:
MGNIFSSMFDKLWGSNKELRILILGLDGAGKTTILYRLQIGEVVTTKPTIGFNVETLSYKNLKLNVWDLGGQTSIRPYWRCYYADTAAVIFVVDSTDKDRMSTASKELHLMLQEEELQDAALLVFANKQDQPGALSASEVSKELNLVELKDRSWSIVASSAIKGEGITEGLDWLIDVIKEEQL
Protein: Zinc finger CCCH-type containing 14 (A0A087WTC9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
ISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEKNQGDLSFLSGCFQDLLFVFDVLQFHYDVSRRGFPFIFPVWYNVWKHPIYLK
Protein: Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A) (Q8N4L2)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity).
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:16365287}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:16365287}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CZX7}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9CZX7}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4
- Phosphatidylinositol polyphosphate 5-phosphatase type IV
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Inositol polyphosphate 5-phosphatase OCRL
- Myotubularin
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
Sequence:
MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPDASGIPVINCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNTFLWMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFARRFRATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHSFA
Protein: Precerebellin-like protein (Q9PT14)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Ig-like domain-containing protein
Sequence:
MESVLAVVVLLCCCMVETQTESEVDGLLRELTARVEKLESKPKVAFSASFMINDEHYHLGPFGENTTVVYEKVITNIGEAYNPDTGVFTAPVRGAYYFTFTCNVGNSGKANAALLKNDVKMVAVYETANPKSGIYHGGANGVTLDLVKGDKVNVVLWSGSSMFDNSRINMFSGYLLFPITTK
Protein: ATPase GET3 (EC 3.6.4.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) (Q6IQE5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O43681, ECO:0000255|HAMAP-Rule:MF_03112}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O43681, ECO:0000255|HAMAP-Rule:MF_03112}. Nucleus, nucleolus {ECO:0000250|UniProtKB:O43681}.
Interaction partners:
- Golgi to ER traffic protein 4 homolog
- Guided entry of tail-anchored proteins factor 1
- Guided entry of tail-anchored proteins factor
- Low molecular weight phosphotyrosine protein phosphatase
- Small glutamine-rich tetratricopeptide repeat-containing protein beta
- Oculocutaneous albinism II.
- Small glutamine-rich tetratricopeptide repeat-containing protein alpha
- Transmembrane protein 208
- Ubiquitin-like protein 4A
- Large proline-rich protein BAG6
Sequence:
MAASVEDEFEDAPDVEPLEPTLKNIIEQKSLKWIFVGGKGGVGKTTCSCSLAVQLAAVRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCRIDTHNIIVNQLVFPDNERPCKMCEARHKIQSKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSKQLLEPYSPPKK
Protein: pH-gated potassium channel KcsA (Streptomyces lividans K+ channel) (SKC1) (P0A334)
Organism: Streptomyces lividans
Function: Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MPPMLSGLLARLVKLLLGRHGSALHWRAAGAATVLLVIVLLAGSYLAVLAERGAPGAQLITYPRALWWSVETATTVGYGDLYPVTLWGRLVAVVVMVAGITSFGLVTAALATWFVGREQERRGHFVRHSEKAAEEAYTRTTRALHERFDRLERMLDDNRR
Protein: Lutropin subunit beta (Lutropin beta chain) (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta) (O09108)
Organism: Mus musculus (Mouse)
Function: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
Subcellular location: Secreted.
Interaction partners:
- Glycoprotein hormones alpha chain
- Lutropin-choriogonadotropic hormone receptor
- Carbohydrate sulfotransferase 8
Sequence:
MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELAFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMACDLPHLPGLLLL
Protein: Uncharacterized protein (Q584V7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLRDGDRYTFQFAELRGDSYYTAFGKITNSFLQMYRNTKHYELILTAFLNRLLEDPTKISSENYKILGDALMGCINTLVAERQAPEPIRRLKARGPDYRRWNENDEDEVFEEESEEEYDEGPQISEEEQKKLEEDRIERERLEEERIAAREEERRRNEEELRSRARQVDRRAMSELLQHVAVMNPGQKKPKGGKQQKQISAETVDDMEIQVTLLRKEKDRIQMVLQYSEEDLPSKLAEAKQQLDEVVSKLNAQGSAKKGDTGTANMGQKQLSSRLSELTQKQTKLTMERNRLALQLKTEPCPLREELLAVLKERDEAQVKVDFA