wanglab/gogpt-training-data huggingface dataset:
Protein: cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (Q585F2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- GST N-terminal domain-containing protein
- Tyrosyl/methionyl-tRNA synthetase, putative
- Methionyl-trna formyltransferase
- leucine--tRNA ligase
- glycine--tRNA ligase
- Valine--tRNA ligase, mitochondrial
- arginine--tRNA ligase
Sequence:
MKESDGLLLADGLNVCEPVKRSRHPPWYPPLNVDGNDVCVLNSMTECLEKFAPREGRLVRWYTCGPTVYDVSHMGHARAYLTFDILRRIMEDFFGYKVIYQMNITDIDDKIIKRARVSSLLRHFRDVTLEGGNMEKLVKFTVEAQRSASRALSETREKLSQALPEGTSSRVRMEREEKIMELALKETQFSDTSGRIQSAIKAGDFDELFDAASGINGDLLDQLEGHTVTDQKIFDDHARRYERLFFEDMKRLGVKDPDVITRVTEYVPQVVNFIQRIMDNGFAYSGETSVFFDTTAFIRAGHNYPKLKPISERDECNTTEAEMAEGEGALAACVAGEKRSPNDFALWKFSKPGEPHWPSPWGAGRPGWHIECSVMASDILGTNMDIHSGGCDLKFPHHDNECAQSEAYSMQHQWVNYFLHCGHLHIKGLKMSKSLKNFITIRHALDDLGVTPRTMRLLFLANQWNKAMNFSDQSIDEAKERERVLRSFFGSVDMVLRSDTLKEIQGFNEHDRKLNEAWISTESAVDAALRNNFDTPTAMEAIMGLVSETNRYLVTGQRPSATLVHKVGRYVTRILQVFGVVDGNDMVGFTKTRQTDDQLVPVMEALLRFRDSVRSEAKASGTTANFLPLCDAIRDEWLAQAGIRIEDSPNGPTTWKRDDPAVLLREISERREQQANDRRRKLQNQIETKKKLVEKWRNYTSSPKDYFKMQSGSVYATFDEETGLPTSNSRGEVVGEKELKKLSKELAKYAKAHEEFNSKGGMEWLLEQEQELANMQESLKSTEVS
Protein: GldL (A5FIS9)
Organism: Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / BCRC 14874 / CCUG 350202 / NBRC 14942 / NCIMB 11054 / UW101) (Cytophaga johnsonae)
Interaction partners:
- GldM
- GldK
- GldN
- SprA
- SprT
- SprE
- GldD
- GldJ
- GldB
- GldO
Sequence:
MALLSKKVMNFAYGMGAAVVIVGALFKITHFEIGPLTGTVMLSIGLLTEALIFALSAFEPVEDELDWTLVYPELANGQARKKEAKAETATDAQGLLSQKLDAMLKEAKVDGELMASLGNSIKNFEGAAKAISPTVDSIAGQKKYAEEMSMAAAQMESLNSLYKVQLESASRNAQANSEIAENAAKLKEQMASMTANIASLNSVYGGMLSAMSNKG
Protein: Probable oxidoreductase (P72043)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Polyketide synthetase MbtC
- Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15
- HTH-type transcriptional regulator AldR
- Probable polyketide synthase Pks17
- Probable polyketide synthase Pks9
- Probable short-chain type dehydrogenase/reductase
- Uncharacterized protein Rv2272
- Uncharacterized protein Rv2273
- Mce-family protein Mce2C
Sequence:
MTIMRAVVAESSDRLVWQEVPDVSAGPGEVLIKVAASGVNRADVLQAAGKYPPPPGVSDIIGLEVSGIVAAVGPGVTEWSAGQEVCALLAGGGYAEYVAVPADQVLPIPPSVNLVDSAALPEVACTVWSNLVMTAHLRPGQLVLIHGGASGIGSHAIQVVRALAARVAITAGSPEKLELCRDLGAQITINYRDEDFVARLKQETDGSGADIILDIMGASYLDRNIDALATDGQLIVIGMQGGVKAELNLGKLLTKRARVIGTTLRARPVSGPHGKAAIAQAVAASVWPMIAANRVRPVIGTRLPIQQAAQAHELMLSGKTFGKILLTV
Protein: High-affinity methionine permease (P50276)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: High affinity permease for methionine.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- E3 ubiquitin-protein ligase RSP5
- Protein LDB19
- Lysine-specific permease
- S-methylmethionine permease 1
- Tryptophan permease
- High-affinity glutamine permease
- Uracil permease
- Oligo-1,6-glucosidase IMA3
- Oligo-1,6-glucosidase IMA2
- General amino-acid permease GAP1
Sequence:
MSEGRTFLSQLNVFNKENYQFSSSTTKKEVSNSTVDADNGASDFEAGQQFATELDQGEKQLGILSCIGLICNRMLGTGVFAVSSTIYTLCGSVGLALIMWAVGAIIAISGLYVYMEFGTAIPKNGGEKNYLEAIFRKPKFFITCMYAAYIFFLGWAAGNSINTAIMFLTAADTEVTKWNQRGIGVAVVFFAFLINSLNVKIGLYLQNILGIFKIGIVLFISITGWVALGGGLKDGYQSHNFRNAFEGTETATAYGIVNALYSVIWSFVGYSNVNYALGEVKNPVRTLKIAGPTSMVFLAIIYIFVNIAYFAVVPKDKLISSKLILAADFFDIVFGGQAKRAAAALVGLSALGNVLSVIFSQGRIIQQLGREGVLPFSNFFASSKPFNSPMVGLFQHFIVCTVTILAPPPGDAYLLVQNLISYPMNIINFAISAGLLWIYWQRRQGKIEWNPPIKAGVFVTGFFTLSNLYLIIAPYVPPSNGESVYSSMPYWIHCVIAWGIFFFGGVYYVVWAQLLPRWGHYKLVSKDVLGEDGFWRVKIAKVYDDTIGDVDTQEDGVIETNIIEHYKSEQEKSL
Protein: Uncharacterized protein Rv2629 (P9WL63)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Probable protein archease
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL23
- RNA-splicing ligase RtcB
- Release factor glutamine methyltransferase
- Universal stress protein Rv2005c
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein uS12
Sequence:
MRSERLRWLVAAEGPFASVYFDDSHDTLDAVERREATWRDVRKHLESRDAKQELIDSLEEAVRDSRPAVGQRGRALIATGEQVLVNEHLIGPPPATVIRLSDYPYVVPLIDLEMRRPTYVFAAVDHTGADVKLYQGATISSTKIDGVGYPVHKPVTAGWNGYGDFQHTTEEAIRMNCRAVADHLTRLVDAADPEVVFVSGEVRSRTDLLSTLPQRVAVRVSQLHAGPRKSALDEEEIWDLTSAEFTRRRYAEITNVAQQFEAEIGRGSGLAAQGLAEVCAALRDGDVDTLIVGELGEATVVTGKARTTVARDADMLSELGEPVDRVARADEALPFAAIAVGAALVRDDNRIAPLDGVGALLRYAATNRLGSHRS
Protein: Ecdysone-induced gene 71Ea (GEO02636p1) (MIP29911p) (Q9VUS3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Ecdysone-induced gene 71Ec
- Ecdysone-induced gene 71Ef
- Ecdysone-induced gene 71Eb, isoform A
- Ecdysone-induced gene 71Eg
- Ecdysone-induced gene 71Ed
- LP05252p
Sequence:
MRLKTVLTIFFAISLTLVAGQDRDCDELARRCESCVRRLNNTIDRDLPLFNRECRQRTELSWRWRNVGRCELSKLNCLGWQSPMNCEDIAMRAGMERRRT
Protein: DSki protein short isoform (A0PDV0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MISTVLKKYQTSATKSLQGPGHALTTAGVLDVVTNGRSESPGLNGKCQASPPVVALIKKEILSSPEPQDLHHHECSTRGTPLQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALPHRSDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFENHTCHWGFDSRNWHDYLHVALDVENREKYQIILDQLKGVELKEMHKAQRELEHKKRKVRWV
Protein: Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (Apurinic-apyrimidinic endonuclease) (EC 3.1.-.-) (P19889)
Organism: Drosophila melanogaster (Fruit fly)
Function: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- Ubiquitin-ribosomal protein eS31 fusion protein
- Large ribosomal subunit protein uL22
- Large ribosomal subunit protein eL15
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein eL39
- FI01658p
- Large ribosomal subunit protein uL6
Sequence:
MVRENKAAWKAQYFIKVVELFDEFPKCFIVGADNVGSKQMQNIRTSLRGLAVVLMGKNTMMRKAIRGHLENNPQLEKLLPHIKGNVGFVFTKGDLAEVRDKLLESKVRAPARPGAIAPLHVIIPAQNTGLGPEKTSFFQALSIPTKISKGTIEIINDVPILKPGDKVGASEATLLNMLNISPFSYGLIVNQVYDSGSIFSPEILDIKPEDLRAKFQQGVANLAAVCLSVGYPTIASAPHSIANGFKNLLAIAATTEVEFKEATTIKEYIKDPSKFAAAASASAAPAAGGATEKKEEAKKPESESEEEDDDMGFGLFD
Protein: Adenovirus death protein (ADP) (Early-3 11.6 kDa glycoprotein) (E3-11.6K) (P24935)
Organism: Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Function: Promotes the release of progeny virus from the host cell nucleus by accelerating the lysis and death of the host cell.
Subcellular location: Host nucleus membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:1448922}. Host endoplasmic reticulum membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:1448922}. Host Golgi apparatus membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:1448922}. Note=Initially associates with the endoplasmic reticulum and Golgi apparatus and ultimately localizes to the nuclear membrane. {ECO:0000269|PubMed:1448922}.
Interaction partners:
Sequence:
MTGSTIAPTTDYRNTTATGLTSALNLPQVHAFVNDWASLDMWWFSIALMFVCLIIMWLICCLKRRRARPPIYRPIIVLNPHNEKIHRLDGLKPCSLLLQYD
Protein: RE33762p (Q8SYU5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Rad, Gem/Kir family member 3, isoform E
- alkaline phosphatase
Sequence:
MSKNCMITFDQNEHGTYFTGQVITGKVIVNLNKTKKLRGIKLQISGYAQAQWRIRRHGKAVAIQNPKKRSKHQYSGREDYIASTTYLMGSEQGSNFNMDAGTYTYTFACPIPSHCPSSFEGAYGHIRYLAKVTFLKPGASNRTHNVGFTVLKLLDLNQETKMLREPASNEAVEHFCLMHTKPVQLKVTLQQQGYVPGQFMLIHAHVRNDSSSDCRKLLIMLHLRATYTADTPSLRTTSEKIMLVKRECGPVAHNAQRTYTETLRIPATAPTCEHLSKVVRVSYEVRVVAVMNWLMANPRLIIPVTIGNVPLATAVSGPDFLPTNAFPSGSSLPADLPCTSTRAMELAQMAASGVSNSGYEMAEDLEDFELPEDGDDELEAADDFVPDLPPPTYEQAMFMTTDIADTDANTVSEASRFTPRYPVFDVDTFQSPPPNPPQKKRRRRRRRPADPGQSKQQPEKQPVESPVQI
Protein: Retrotransposon Gag-like protein 4 (Mammalian retrotransposon-derived protein 4) (Sushi-XF2b protein) (Sushi-ichi-related retrotransposon homolog 11) (Zinc finger CCHC domain-containing protein 16) (Q3URY0)
Organism: Mus musculus (Mouse)
Function: Involved in cognitive function in the brain, possibly via the noradrenergic system.
Interaction partners:
- Retrotransposon Gag-like protein 6
Sequence:
MEKCTESLPNLNAETSFLRGGNLILQPQVQHPTDDKPPITGQVVPALNTPVMSGPYSGDHIPQFHGNPASVKGFFAQVTTYLRALDISNPADNARVKHFFDYLSQQMQNCDVLSESTQNNLLKQYENFVLELQQSFGEPMTQETTPPMNVTVDKSNISPQDATNFQLHAPNLSYRETNQRDQFQNGQADPTQNEEITDIMDNLPDLITQCIQLDKKHKDRPELLQSESHVPMFASTNHYQSFIGPVRPLPKDGPRQLQGAHLPVTPAKRARQQETQLCVYCNQAGHFTRDCLAKRSRTPARKKM
Protein: adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) (Q380Y3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Phosphodiesterase
- Phosphodiesterase
- 3', 5'-cyclic nucleotide phosphodiesterase, putative
- Expression site-associated gene
- Leucine-rich repeat protein
Sequence:
MNMLHLSDRNASLAPSGGEHSLPTGGAVCRVAMDVLPVILRAPVALLLLLIVLPQLSVGAEANATVKVLSAAWNSYMPQEYVTAINAGFSASLESRQWTVAGSVKVEVVYPERYETLPEDFIKEQLELETDQNKIVIVYGPLGDKSVIYSIPYLVNHSVVALGLMTGSGEVRRWNPYLYFLRADPAAETLALIRYALCQLRVLRLGFMYLQGVHYGDEEYALTVNVMSQMGYELHGVFTVMSPDGEPAPDDEFKEAFERFAAALPQAIIVFGAPEKDTAKFLMMMVAEERVARSYILGPSSVQVSLAEMWRLALEAAGASFAPGQLLFTGTNPLAKDSQYIAIKRFQGVMSEYLKAHVGETNITETDYFLTHDPEGELMVYGWIAGEVLTQALSSLEWLKDRATFVRSLYSQRRYVINDIVIGDYGGTCEGEAAKHGATCECNQGSKAVYVKEVLEDGRTTTMASGFTVVKASQCYAESSELHGPLNGLAVFMEDDDTASKAAALWHKGASHLVGKGDLGHSDRFFLHAFNTTIAEAANDLRHEQGERIVTAVFGPVTEAMLDTPNITFIDPLELKPRLNKFRRNVIHLSPTLEQQLYVLSSYLAGDGVGTVDAVICSNEADGIADFLRRSLTEFGVSLRSAVIREDGEGVGKYLPMSGIVFVIGLSVPDVREIARKLEERNDLRVIVLFAEFSLLYDLFTSTLNNTAGAARLVFATSLPHWGDTETSSKTTQLFHDVEKDSRLWTPLSLLAFATGRLMRAILLRVEEMSPETLVNFFYADSSIISDDMRYGVFDDTKCDGAENISEGDCASNYGATQISVWSMARALNASILPLTNPMTPSMSFRDPSEGKLSGAPLVGVIIGATFALFLVVALGVVPYFVLRNTRDNNSAPKEPTEPVTIVFTDIESSTAQWAAHPDVMADAVAAHHKLIRALISQYECYEVKTVGDSFMIASRSAFMAVQLVRDLQRAFLRHNWGASVFDEYYCRLEQDRALESEGYVPPTARLDPDVYRKLWNGLRVRVGVHTGLCDIRHDEVTKGYDYYGHTSNMAARTESAANGGQILLTRATYLSLSTAEREQLDVTALGAVPLRGVPDPVEMYQVDAVVGRSFAALRLDREVDLVADSGVTNLSTSDCASLCELGQSAQTIVAVMRALFGTFTASQREKLLVPFCERWRVTLPPKTKSVWDDNYCQEVVRRIAAKVGHVVDFTAYNIAEPPLTTSSSSSVIFISDAAVGLCAVGERNVSTPKEEN
Protein: Zinc metalloproteinase-disintegrin-like VaH1 (EC 3.4.24.-) (Snake venom metalloprotease) (SVMP) (P0DJ44)
Organism: Vipera ammodytes ammodytes (Western sand viper)
Function: Snake venom zinc metalloprotease that exhibits strong hemorrhagic activity. It also degrades alpha-chain of fibrinogen (FGA), but not the beta- and the gamma-chains. Possesses potent azocaseinolytic activity and cleaves insulin B-chain, hydrolyzing it at positions Ala(14)-Leu(15), followed by Tyr(16)-Leu(17) and His(10)-Leu(11). In vivo, subcutaneous injection into mice induces strong hemorrhage.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MVTKYSSIFMSPILSNPPILYFSDCSREXYQKXLTN
Protein: At1g20670 (DNA-binding bromodomain-containing protein) (F2D10.15) (Q9LM88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- SWI/SNF complex subunit SWI3C
- Histone acetyltransferase subunit NuA4-domain protein
- Probable serine/threonine-protein kinase PBL21
- Histone acetyltransferase of the MYST family 1
- Histone acetyltransferase of the MYST family 2
- DNA-binding bromodomain-containing protein
- SWI/SNF complex subunit SWI3A
- Cyclin-B2-3
- SWI/SNF complex subunit SWI3B
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
Sequence:
MGEVADTMTKKKKKGRPSLLDLQKRAIKQQQQQLQQQQQQHKNNHQDDDDHHHNNNNRSGSKNPNSLNHRSKRRNPNSNDGDSPWIKDEGEDNDDDERREKKHKLLHGLNSHSHRHSPNSQSDLNLDQTPEPSFNRRNLSAAASGSDYHTGEKASKATDILQGSPVESGPTTPLPDKKLLLFILDRLQKKDTYGVYSDPVDPEELPDYFEIIKNPMDFSTLRNKLDSGAYSTLEQFERDVFLICTNAMEYNSADTVYYRQARAIQELAKKDFENLRQDSDDEEPQSQQQQQQQPKVARRGRPPKKHPEPSSIDRTASEISADALIPGDSSNKFSGAYNLRKAPPSYKFRQAESSVRINHNSETQSGWSVDWESEFPSSVVKAVNKYGMKHFNVDDNRRDTYNHLSTSTQEPSVLTTLEDELKQLIPVGLNMEYGYAKSLARYAANLGPVAWKIASRRIETVLPSGIKFGQGWVGENPAGPEEDDSQKQNILMSSGKQKCSNDLASDDHSNRILSPTASVSSAFIGNRHASSQAIEETTPPPARVLNPEIDHPSSSSHQAGLLIKTESSNGLIRGFNHNANQMLGIARQQQPNVSNEATPVSQQQGSLFPYPKQEFHRFPPDLNARLVSPNSPGSNQQTGSSSSQHPDLALQL
Protein: Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (Q7TMB8)
Organism: Mus musculus (Mouse)
Function: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11438699, ECO:0000269|PubMed:14765121}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11438699}. Cell projection, lamellipodium {ECO:0000269|PubMed:14765121}. Cell projection, ruffle {ECO:0000269|PubMed:14765121}. Synapse, synaptosome {ECO:0000269|PubMed:11438699}. Note=Highly expressed in the perinuclear region (PubMed:11438699). Enriched in synaptosomes (PubMed:11438699). Also enriched in membrane ruffles and at the tips of lamellipodia (PubMed:14765121). {ECO:0000269|PubMed:11438699, ECO:0000269|PubMed:14765121}.
Interaction partners:
- RNA-binding protein FXR1
- Actin-binding protein WASF1
- Abl interactor 1
- Nck-associated protein 1-like
- Abl interactor 2
- Fragile X messenger ribonucleoprotein 1
- Nck-associated protein 1
- RNA-binding protein FXR2
- Eukaryotic translation initiation factor 4E
- Actin-binding protein WASF2
Sequence:
MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCASSSSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDNAEEYERATRYNYTTEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTKFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSVVELDGLLEINRMTHKLLSRYLTLDSFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAVLFCLLIEQSLSLEEVCDLLHAAPFQNILPRIHVKEGERVDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRTFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGESTPVEHVRCFQPPIHQSLASS
Protein: Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (3-OST-3B) (Heparan sulfate 3-O-sulfotransferase 3B1) (h3-OST-3B) (Q9Y662)
Organism: Homo sapiens (Human)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
- Sulfotransferase 1C3
- Sulfotransferase 1C4
- Sulfotransferase 1B1
Sequence:
MGQRLSGGRSCLDVPGRLLPQPPPPPPPVRRKLALLFAMLCVWLYMFLYSCAGSCAAAPGLLLLGSGSRAAHDPPALATAPDGTPPRLPFRAPPATPLASGKEMAEGAASPEEQSPEVPDSPSPISSFFSGSGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWD
Protein: Centromere protein W (CENP-W) (P0DJH6)
Organism: Gallus gallus (Chicken)
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:19070575}. Chromosome, centromere {ECO:0000269|PubMed:19070575}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19070575}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis (PubMed:19070575). Localizes to the inner kinetochore. {ECO:0000269|PubMed:19070575}.
Interaction partners:
- Centromere protein X
- Centromere protein S
- Centromere protein T
- Centromere protein N
- Centromere protein K
- Centromere protein I
- Centromere protein M
- Centromere protein U
- Centromere protein Q
- Centromere protein P
Sequence:
MRRTVPRGTLRKIIKKHKPHLRLAANTDLLVHLSFLLFLHRLAEEARTNAFENKSKIIKPEHTIAAAKVILKKSRG
Protein: Amino acid transporter (A0A3Q1LFK0)
Organism: Bos taurus (Bovine)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}.
Interaction partners:
Sequence:
MDANNMPKQVEVRMHDSHLSAEEPKPRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSDEDGNATNAVLSLLNETVTEVPEETQVVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFLVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDLKNHRESNSNQCVYAAHNSVIVDECKVTLAANGKSADCSVEEEPWKHEK
Protein: Collagen alpha-1(XXI) chain (Q96P44)
Organism: Homo sapiens (Human)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11863369}. Cytoplasm {ECO:0000269|PubMed:11863369}. Note=Found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle.
Interaction partners:
- Collagen alpha-1
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
- Collagen alpha-2
- Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
- Procollagen galactosyltransferase 2
- Collagen alpha-1
Sequence:
MAHYITFLCMVLVLLLQNSVLAEDGEVRSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDSGEHLTAAVESILYLGGNTKTGKAIQFALDYLFAKSSRFLTKIAVVLTDGKSQDDVKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIREVMKQKLCEESVCPTRIPVAARDERGFDILLGLDVNKKVKKRIQLSPKKIKGYEVTSKVDLSELTSNVFPEGLPPSYVFVSTQRFKVKKIWDLWRILTIDGRPQIAVTLNGVDKILLFTTTSVINGSQVVTFANPQVKTLFDEGWHQIRLLVTEQDVTLYIDDQQIENKPLHPVLGILINGQTQIGKYSGKEETVQFDVQKLRIYCDPEQNNRETACEIPGFNGECLNGPSDVGSTPAPCICPPGKPGLQGPKGDPGLPGNPGYPGQPGQDGKPGYQGIAGTPGVPGSPGIQGARGLPGYKGEPGRDGDKGDRGLPGFPGLHGMPGSKGEMGAKGDKGSPGFYGKKGAKGEKGNAGFPGLPGPAGEPGRHGKDGLMGSPGFKGEAGSPGAPGQDGTRGEPGIPGFPGNRGLMGQKGEIGPPGQQGKKGAPGMPGLMGSNGSPGQPGTPGSKGSKGEPGIQGMPGASGLKGEPGATGSPGEPGYMGLPGIQGKKGDKGNQGEKGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQVCTDVIRAQLPVLLQSGRIRNCDHCLSQHGSPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGYPGEQGPPGPPGPEGPPGISKEGPPGDPGLPGKDGDHGKPGIQGQPGPPGICDPSLCFSVIARRDPFRKGPNY
Protein: Chromatin assembly factor 1 subunit A-A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit A) (CAF-I 150 kDa subunit A) (CAF-I p150-A) (xp150) (Q98TA5)
Organism: Xenopus laevis (African clawed frog)
Function: Involved in chromatin assembly in DNA replication and DNA repair.
Subcellular location: Nucleus {ECO:0000269|PubMed:11296234}.
Interaction partners:
Sequence:
MPGKEAAVNVMQSSTKSNTKKMVQARLPFKRLNPVPKDEGCLEEKKVRITKNVSPQKMLHSLNSSMEDMENDCDMETETVPIPKAVNGKGPLDNYIRKAPKVSHAPSITTIDLTEESNISISNDCPLNGESETHLANGTLALEESTPNLPLSAKEECTVSLENKTVENTHFSELKSDQLHQAAATSTSASNFSPERVVKEDCNSSADDDSASVSSSSSPVSLSSPDAQTGSQFRNRSSPSTSTTPTGKVTANKTSADKNKTKDKDKQRQAEKEERERAKKEARSAKKKKRQGLLKNLQRKRGKTSESSGKEYKKEKKEREDKEKAEKMKLKEEKKREKLEALEAKQEEKRKKDEEKRQKEEEKRQKEEEKRLKEEEKRVKAEKAEITRFFQKPKTPQAPKTFSRSCGKFAPFEIKKGMALAPLCRIDFEPEASEELDRFLQEQNSKIYFFDEIKKRKPRKMGQTTVPTVNSFEVDDVQVLGESDPVLGSNMLEGHIKDIGVPERKKFGRMKLLQFCENHRPAYWGTCNRRSRVINSRKPWAQDTGMLDYEVDSDEEWEEEEPGESLSHSEGENDDDPKEDDEDDDGFFVPHGYLSDDEGVSDEECTDPENQKFRQKLKAKEWYELQTNGKKIRAMQPVVIGCVWWDSKASEISLLQKFSACILESPAVDEELAQEISSAQSLKDRQILSKLVPLLHGNVNGSKIMIQEFQEYCRRGLFLEDNASDAAGNESTSPNVTPQTPSNIIVPSKARLKRLISENSVYEKRPDHRMCWYVHSDVLKGLQQDNLPVPCQWTYITQVNSVAKEDNGANGGSLQSLPLSGKRKSAGSMPITKFMKRAKDLETAINTDMDGFQADNEEDDDDCMILEDQQAKDAEDSTIECKINLNDSAVLASCQN
Protein: Killer cell lectin-like receptor subfamily B member 1C (CD161 antigen-like family member C) (Lymphocyte antigen 55c) (Ly-55c) (NK1.1) (NKR-P1.9) (NKR-P1C) (Natural killer cell surface protein P1-40) (NKR-P1 40) (CD antigen CD161c) (P27814)
Organism: Mus musculus (Mouse)
Function: Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.
Subcellular location: Membrane; Single-pass type II membrane protein.
Interaction partners:
- C-type lectin domain family 2 member D
- High affinity immunoglobulin epsilon receptor subunit gamma
- Natural cytotoxicity triggering receptor 1
- Receptor-type tyrosine-protein phosphatase C
- T-cell surface glycoprotein CD4
- Integrin alpha-X
- Integrin alpha-M
- Interleukin-7 receptor subunit alpha
- B-lymphocyte antigen CD19
- Interferon gamma
Sequence:
MDTASIYLGLKPPRTLGAWHESPPSLPPDACRCPRSHRLALKLSCAGLILLVLTLIGMSVLVRVLVQKPSREKCCVFIQENLNKTTDCSVNLECPQDWLLHRDKCFHVSQVSNTWEEGQADCGRKGATLLLIQDQEELRFLLDSIKEKYNSFWIGLRFTLPDMNWKWINGTTFNSDVLKITGVTENGSCASILGDKVTPESCASDNRWICQKELNHETPSNDS