wanglab/gogpt-training-data huggingface dataset:
Protein: DEC-205 protein (Q4LDF5)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGRPAGRCAAACCIAWLLACCAARRDDTGSGAFTIRHDTLNKCIQVKNSRIVVDDCKETSEALWKWVSQSRLFHLGTKQCLGLDIFTKLPSRLRMVDCNSDLRLWWRCADGSVVGASQYKVTVRSAYVTASINASDQWRSNNSSADICQYPYHEIYTKDGNSYGKPCEFPFLYNMTWHHDCIQDGTHTGRKWCATSEDYTRDGKWGICLQPEDGCHDIWEHDASSQHCYQFNTQSALSWKEAYVSCQRQGGDLLSIQDASELNYIQAKDDIAEIFWIGLNQLDVSRGWQWSDHKPLNFVNWHPDMWDLSPLDGTSCVAMNAASGQWRSYHCGNPLPYVCKKSFKEVSNLTEFWRHVNTRCDAGWLPHNGFCYMLIHNQASWSTADQLCKANKSNLISIHSLADVELIVTKLHNDAREEVWVGLRNEDVPTLFKWSDRTDVVFTYWDQNEPSVPFNATPNCVSYSGKLGQWRVKSCEENLKYVCKKKGKILNETKSDKNCSLDEGWEMHGNYCYKILNTEVSFGAECNLTVTNRFEQEFINSLIRKHTKVEEKYFWTGLQDISQSGMYSWAAVDGEKSEAVTYTNWNSLQPEFSGGCVAMSSGRSLGKWETKDCKTTKAFPVCKKYIGLPKEPEVLPKPSDPCPPGWHNGSGLACYKFFHSERVLRTRTWEEAERFCEALGGHLPSFTHTEEIKTLHSILRKIISNDRWVWVGMNKRSPDSLGTWQWSDDKPVTSLVLPHDYLEDEYDTRDCVALKTFQFSRRSFWRFYFHEGRDLEFYFKPFDCEAKLEWVCQITKGSTPKTPEWYIPDEIGIHGVPLVVDGAELWFVPDKNVSFQEAISYCQKNDSELASVESYPKLRTILSQIEKLSNSEQKWWLKFIDYGYSYHSPLQLFPRFHDRSLRDCWYVSRKSWYRDYPVNCNMKLPFICEKNNASLLEKHDPSYRPVTGGCPKGWLRFRNKCFLKMKSEYLTFNAANEKCVTFGGSLPCISSQAEQDFITSLLPQMPRDIWIGLQFLFSTRENKWIDESRLLYSNFHPLLTGRLRKIPLDLFDEEFNNQCGVILNDPKSHYVGTWNFTACADRHFLGICQRPIGIGAADNQTEQVLNDTFSYHNVQYKLILNNLTWNDAMAACIGQKMQLVSITDQFQQASLAVQAALHDYPLWIGLFSRDGGKHYGWLDGKHVSFSRWSEDDEETSEECVYLDTDGFWKTSDCYSENRGAICYSSEKKDEKEQVTQVKCPHKIKNTPWISFRNNCYTFMITKNRWREMKSQEAHHLCKKMNPEAFVLSVRDEEENNFVAEQLHSFSGLAVWVWLGVIYDDSDKVLKWYDETYLTYNNWRLGRPIIKKNSFFAGVNLDGFWDIYNYSQSWQAHHYNVYSILACKIERGPQQHKPPLPEFIPHGDVTYRILQKKLTWYDAVRECKQNMSDLASVHSESQQLFLEDIVKQDGYSLWLGLSIHDGSKANFEWSDGSSFDYYPWELENSNTTENCVLLDTKGSWNRAKCTNVAEGAICYSFSNKKQLEQKQVSRASGCSQLSGELPWIQYKDHCYAFDMAFYNFSVYNVEDAKKVCKKLNPSAALLTIGDAEENAFVSAHIKKNDLITRKVWLGLTQSSTGQTLHWLDGSSVNYANWDNRTTELSEKCSVITSTTGKWSKVDCSRSQSRVVCKAPLGSNHTGVAVAFALLVILVLVLGLVWFICKKKRLHWSAFSSVHYQRGLNDDEADDVFTKDGY
Protein: Germ cell nuclear acidic protein (Acidic repeat-containing protein) (Germ cell nuclear antigen) (A0A1D9BZF0)
Organism: Mus musculus (Mouse)
Function: May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage. Can resolve the topoisomerase II (TOP2A) DPCs.
Subcellular location: Chromosome {ECO:0000269|PubMed:31839538}. Nucleus, PML body {ECO:0000269|PubMed:31839538}. Nucleus {ECO:0000269|PubMed:27718356}. Note=Co-localizes with SUMO2 at PML bodies in all interphase cells (By similarity). Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase (PubMed:31839538). {ECO:0000250|UniProtKB:Q96QF7, ECO:0000269|PubMed:31839538}.
Interaction partners:
Sequence:
MDSGSSSSSSSSGSSSGSCSTSGSGSTSGSSTTSSSSSSSSSSSSSSSSSSKEYMPELPKQRKASCVVIDSESDSDNTSDEKNTTVCEISSGDETSDIDRPGGQKLPLIVIDDDDDGSPDLKNTKQKSDEPQMSVLEKEGVECIGSDSTSPHDVCEIWDVCGSSNQTSSELEPEGEPESEAKGEPESEAKGEPESEAKGEPESEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGEPESEAKGEMETEAKGEPESEAKGEMETEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGEPESEAKGEMETEAKGEPESEAKGEPEPEAAKGEMETEAAMGEVETEAAMGEPEQEITAEEAKKKRAAYLLAQQRKRKRKNRFICMSSSKPRRKRRRADPQDGADPQDGADPQDRADPQDLADPQDRGDSQDMPSLPGTSDEPIPSGQPVCPRKGMASSRGRGRGRGRGRGRGRGRGRGRGRGAKAGK
Protein: CD4-1 molecule precursor (CD4-like protein 1) (Q1W651)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Interaction partners:
Sequence:
MSFLLGLLLLLAPCHSAADEPKGIFAQFGNSVTLPRRIWGIEGKIHVNWYFQDNLLISRNPTLSASKTVHNRFSLSSDSSLIISNVEKSDFGIFKCEQHHLVETITDTYKLYEVMMSTPPPLLVGASLDLSCEIESEGFKLVHEIKWFGPDNTLYVGSSSSNQRTLRVTKVSSIHSGKWTCAVRYGASITLKARTDVIIVDLASSSPDPIYTSDSSINFLIPCSLSSKIPWSTVNATGVTGGSWHFTPFKSSESSLPLLKLQLNPSPAWKFPSGTHTLLMETDLKNHELGVKISKVSINERGNYTCSLEFGSRTLSRSVQVEVLQVISSEGKVIYEGNTVNLTCTLGHHMTPDLEVNWIPPYGSSLSKLSPPYTTMLSIPGVSVKDSGRWTCQLKKNATLLTSATISLKIEKAPVNIWLVVAIIGGLLVFILIAVITVFIIRRHRQMMRYRCRKGRVCCCKNPKPKGFYKT
Protein: Protein LTO1 (LTO1 family protein YNL260C) (P53846)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for life in oxygen, but nonessential under anaerobic conditions. Required for biogenesis of the large ribosomal subunit and initiation of translation in oxygen. The complex LTO1:YAE1 functions as a target specific adapter that recruits apo-RLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery.
Subcellular location: Nucleus {ECO:0000269|PubMed:23318452}.
Interaction partners:
- Protein YAE1
- Translation initiation factor RLI1
- Uncharacterized protein YJR012C
- Cytosolic Fe-S cluster assembly factor CFD1
- Fe-S cluster assembly protein DRE2
Sequence:
MDFDNLLNLEEQYYQEGFLEGQNENIKQSFLEGKQYGLQVGFQRFTLLGQMEGLCDVIESYGLHSPTLEKNIHTIRTLMKGLKMNNDDESVMEFERVLIKLKNKFRTILITLHRLVKDKRTPTVTFEVFEDVSRAIAGEIRGFVENEDIAKNKTKQNQAQSW
Protein: UDP-glucuronosyltransferase (EC 2.4.1.17) (D3XD58)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Membrane {ECO:0000256|RuleBase:RU362059}; Single-pass membrane protein {ECO:0000256|RuleBase:RU362059}.
Interaction partners:
Sequence:
MNDRIVRMAASALVLCLFCLVSAEAGNLLVIPALGSHWTGTRPLVEELGRRGNRVVVVFPEENVNMVPAKHTTTLTYPVPYTKAQIQKGTDAAISKLFSADVSSDVGRFQNFFTTMDMLKVIISRNAEGLLLNKDLLKKLQDYNFDAILTDPFETVGVIASEYLSIPAIYMQTSHPCGADVLASQCPAPPSYVPKGLTHFTDRMNLWQRSVNFVRTLVQPVACSRMFAHADEIASKVLQKKTSVMEIMSRAALWFMHFDFAFEFPRPVMPNMVVIGGVDTKKPEPLSQELEEFVNGSGEHGFVVFTLGSMVSQLPEAKAREFFEAFRQIPQRVLWRYTGPVPENAPKNVKLMKWLPQNDLLGHPKVRAFVTHGGSHGIYEGICNGVPMVMLPLFGDQGDNAQRLVSRGVAESLTIYDVTSEKLLVALKKVINDKSYKEKMMKLSAIHRDRPIEPLDLAVFWTEFVMRHKGAEHLRPAAHDLNWIQYHSLDVIGFLLLILLTVIFVTVKSCMFCFRKCFKKSQKKKKA
Protein: DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) (Q60596)
Organism: Mus musculus (Mouse)
Function: Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (By similarity). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P18887}. Chromosome {ECO:0000250|UniProtKB:P18887}. Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage. Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains. {ECO:0000250|UniProtKB:P18887}.
Interaction partners:
- Bifunctional polynucleotide phosphatase/kinase
- DNA polymerase beta
- DNA ligase 3
- Poly [ADP-ribose] polymerase 1
- Aprataxin
- Aprataxin and PNK-like factor
- DNA ligase 1
- N-glycosylase/DNA lyase
- Poly [ADP-ribose] polymerase 2
- X-ray repair cross-complementing protein 6
Sequence:
MPEISLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGATAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRIFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPYGLSFVKFHSPPDKDEAEATSQKVTVTKLGQFRVKEEDDSANSLKPGALFFSRINKTSSASTSDPAGPSYAAATLQASSAASSASPVPKVVGSSSKPQEPPKGKRKLDLSLEDRKPPSKPSAGPSTLKRPKLSVPSRTPAAAPASTPAQRAVPGKPRGEGTEPRGARTGPQELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTPDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHHMRRRLPSRRYLMAGLGSSSEDEGDSHSESGEDEAPKLPQKRPQPKAKTQAAGPSSPPRPPTPKETKAPSPGPQDNSDTEGEESEGRDNGAEDSGDTEDELRRVAKQREQRQPPAPEENGEDPYAGSTDENTDSETPSEADLPIPELPDFFEGKHFFLYGEFPGDERRRLIRYVTAFNGELEDYMNERVQFVITAQEWDPNFEEALMENPSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA
Protein: Sex comb on midleg-like protein 4 (Q8N228)
Organism: Homo sapiens (Human)
Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MQSQRIPGRKRGRPSLHSTPMKMAVHNLYSASAGSLPAVKIPKKRGRKPGYKIKSRVLMTPLALSPPRSTPEPDLSSIPQDAATVPSLAAPQALTVCLYINKQANAGPYLERKKVQQLPEHFGPERPSAVLQQAVQACIDCAHQQKLVFSLVKQGYGGEMVSVSASFDGKQHLRSLPVVNSIGYVLRFLAKLCRSLLCDDLFSHQPFPRGCSASEKVQEKEEGRMESVKTVTTEEYLVNPVGMNRYSVDTSASTFNHRGSLHPSSSLYCKRQNSGDSHLGGGPAATAGGPRTSPMSSGGPSAPGLRPPASSPKRNTTSLEGNRCASSPSQDAQDARRPRSRNPSAWTVEDVVWFVKDADPQALGPHVELFRKHEIDGNALLLLKSDMVMKYLGLKLGPALKLCYHIDKLKQAKF
Protein: Apyrase (EC 3.6.1.5) (O96559)
Organism: Cimex lectularius (Bed bug) (Acanthia lectularia)
Function: Inhibits platelet aggregation by the calcium-dependent hydrolysis of ATP and ADP.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MRSSYRVGNPIRFQPTNVVGLLLLSLVLSFMLVQSYELGHASGETNANSKYPLTTPVEENLKVRFKIGVISDDDKNAVSKDESNTWVSTYLTGTLEWEKSTDKITVQWDKGNEKKVKSKYSYGGRGMELSELVTFNGNLLTFDDRTGLVYILKDDKVYPWVVLADGDGKNSKGFKSEWATEKAGNLYVGSSGKEWTTKEGTIENYNPMWVKMINKNGEVTSLNWQTNYEKIRSSMNITFPGYMWHEAACWSDKYNKWFFLPRALSQEAYDSKKFETQGANVIISCDDKFEKCEPTQIQGKTEDKRGFSNFKFVPTSEDKIIVGLKTVEADDTTETYFTAFDLEGKVLLEETKIDDHKYEGVDFV
Protein: Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) (P63170)
Organism: Rattus norvegicus (Rat)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P63167}. Chromosome {ECO:0000250|UniProtKB:P63167}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8702622}. Nucleus {ECO:0000250|UniProtKB:P63167}. Mitochondrion {ECO:0000250|UniProtKB:P63167}. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. Recruited to DNA double-strand breaks (DSBs) by TP53BP1 when phosphorylated at Ser-88. {ECO:0000250|UniProtKB:P63167}.
Interaction partners:
- Dynein light chain Tctex-type 3
- Cytoplasmic dynein 1 intermediate chain 1
- Cytoplasmic dynein 1 intermediate chain 2
- Cytoplasmic dynein 1 light intermediate chain 2
- Cytoplasmic dynein 2 heavy chain 1
- Cytoplasmic dynein 1 heavy chain 1
- Bcl-2-like protein 11
- Dynein light chain 2, cytoplasmic
- Cytoplasmic dynein 2 light intermediate chain 1
- Dynactin subunit 4
Sequence:
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
Protein: Zinc knuckle (CCHC-type) family protein (Q9FIX7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 9
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase iron-sulfur protein 6
- NAD
Sequence:
MGDGDEQSKELGGVSSSSRRCSSGTAGAANAEARMKFAAVDAITELVWSPSNGLSLRCADISFTGKAKLLSPNFFDIGLTNMAIHSNSTSIEDQEDHVDVELRNRDQVNQAMIGGSVEDMKPEMVEDKVETNDDIKNEEAGCSKRSSDSPKAMEGETRDLLVNEQLRMESAGSQEEGDKAHNRVDRLESMDENNLATLAVVACEGKGDYLPEGEAGPSGSYRRREKAKGKEKALSDENFGGDGEDEDEESFGSVESCNSAGLLSRGKKRPGFEEQLIFGSKRLKTLNQECLGSTSKLKQDSSFMNWISNMTKGIWKGNEEDNSPFVALTTTSNANGHGQVNAIVDQQQLSPCCVKENSGCRNTGFQSFFQSIYCPKKQSQDVVDMDFPNDVNAAPLQELPWIPEHCDISKGDDLSSSGNEIGPVAEPNISSGKVVFNQTSKTQSSENKREDKEPNISLMSLSKSKPNEEPKTCGEADGKVSPCLTNRNSGLKSLWISRFSSKGSFPQKKASETAKEANASASDAAKTRDSRKMLADKNVIRPSISSVDGPDKPDTVLPIVSSMRIESSEAMASLFARRLEAMKSIMPSGSLAENAEEEQRDLICFYCGKKGHCLRDCLEVTDTELRDLVQNISVRNGREEASSLCIRCFQLSHWAATCPNAPLYGSGAEGRAMKNALASTSGMKLPISGFTDVPRAVFDAVQVLRLSRTDVLKWINTKKSVSGLEGFFLRLRLGKWEEGLGGTGYYVARIDGDTEGQSSRRHSEKSLISVKVKGVTCLVESQFISNQDFLEEELKAWWQSAGKSARTSGYDGIPSAEELSRKIQQRKMLGF
Protein: Acetylxylan esterase A (EC 3.1.1.72) (Q5B037)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Acetylxylan esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Degrades acetylated xylans by cleaving acetyl side groups from the hetero-xylan backbone.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Endo-1,4-beta-xylanase B
Sequence:
MVKLQYLLSILLYAYSCTALMLDRRDPTPGQLSQVTDFGDNPTNVGFYIYVPQNLASNPAIIVAIHYCTGTAQAYYSGTPYAQYAETYGFIVIYPESPYSGTCWDVSSQSTLTHNGGGNSNSIANMVDWTINQYNADASRVYVTGTSSGAMMTNVMAATYPNLFAAGIAYAGVPAGCFYSEANVEDQWNSTCAQGQSISTPEHWAQIAQAMYSGYEGSRPKMQIYHGSADATLYPQNYYETCKQWAGVFGYNYDSPQEVQNDTPVAGWAKTIWGENLQGILADGVGHNIQIQGEEDLKWFGFTS
Protein: Wax ester synthase/diacylglycerol acyltransferase 4 (WS/DGAT 4) (Diacylglycerol O-acyltransferase WSD4) (EC 2.3.1.20) (Long-chain-alcohol O-fatty-acyltransferase WSD4) (EC 2.3.1.75) (Q9M3B3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional wax ester synthase/diacylglycerol acyltransferase (By similarity). Involved in cuticular wax biosynthesis (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5KS41}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q93ZR6}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Thylakoid soluble phosphoprotein
- Leucine-rich repeat protein kinase family protein
- Protein DETOXIFICATION 51
Sequence:
MEIETRPHISGDEKEEEQPLSPAARLFHAPEFNCNIISVIGFKSKLDPCVFIRGFKESFIRHPRFSSKLVTDENGQNQRWVRTNVVVEDHFIVPKIKPQNIENSNAFLEDYVSDLMKIPLDTSRPLWELHLLDLKTSDAENVAVLKIHHSVGDGMSIMSLVLACMRKTSNPDELPSLPYQYRSSSRSSLLTTGSRSDSRLLWLVKVIWTAVILGLNTVCDALEFIVTTLFVKDTETPIKGDFLSTKSKQLRLVHRTVSLDDIKLTKNAMNMTINDVVLGVTQAGLSRYLARRYGEEETKNRKQKKLPKRIRLRSALLVNLRPTTGIQDLADMMEKGSKCRWGNWFGYVVFPFSIALRDDPLEHLEIAQKTISRKKNSYGAMLTYIFCRIIVKLLGIKVAASIINRMVSNTTMTFSNMVGPVEEVSFYGHPITYFASSAYGHPHALTIHCQSYMNKMTITLIVDPTVISDPHRLCDDWEESLRSIKAAVTKRESLRLWDYLRILHNRVAWLLYQIAGLLYRML
Protein: 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) (Q5AI24)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- 3-hydroxyisobutyrate dehydrogenase
- Mitochondrial 37S ribosomal protein MRP4
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein mS29
- Mitochondrial 37S ribosomal protein MRPS28
- Small ribosomal subunit protein mS23
- Mitochondrial 37S ribosomal protein MRPS17
- Small ribosomal subunit protein mS35
- Peroxisomal hydratase-dehydrogenase-epimerase
Sequence:
MLRLNNSISLLKQVRKIATTSINMSSKLSTNHTSGGEEPVVLSSVKNHARLITLNRVKKLNSLNTEMIELMTPPILEYAKSKENNVIILTSNSPKALCAGGDVAECAVQIRKGNPGYGADFFDKEYNLNYIISTLPKPYISLMDGITFGGGVGLSVHAPFRVATEKTKLAMPEMDIGFFPDVGTTFFLPRLNDKLGYYVALTGSVLPGLDAYFAGFATHYIKSEKIPQLINRLADLQPPAIEDDITVLSGNNQYFNQVNDILNDFSEKKLPEDYKFFLSTEDIATINKAFSQDTIDDVLKYLENDGSPFARKTLETLLKKPKSSLAVGFELMNHGAKNSIKKQFELEMVSATNIMSIPAEKNDFAKGVIHKLVDKIKDPFFPKWSDPSTVTQQFLSNILSTSKNTDKYLKTPFIKKWFGVDFEDYPHQMGLPTNKQVADYISGSDGSNRTYLPTPAEVFKHFKQKTNNKLGVDEKIKQILDLHGETAKYDHKYVTWKEEPTK
Protein: U6 snRNA-associated Sm-like protein LSm8 (O95777)
Organism: Homo sapiens (Human)
Function: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
Interaction partners:
- U6 snRNA-associated Sm-like protein LSm2
- 116 kDa U5 small nuclear ribonucleoprotein component
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein Sm D2
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm6
- U4/U6 small nuclear ribonucleoprotein Prp3
- U6 snRNA-associated Sm-like protein LSm4
- Pre-mRNA-processing-splicing factor 8
- U6 snRNA-associated Sm-like protein LSm5
Sequence:
MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH
Protein: ADP-ribosylation factor 6, putative (Q38BH5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Tubulin folding cofactor D, putative
- GMP phosphodiesterase delta subunit domain-containing protein
- RNA cytidine acetyltransferase
- Centrin, putative
Sequence:
MGLLSIIRKTKRKEREMRILMLGLDNAGKTTCVKKFCGKDTSSISPTLGFQITAFSLNGCTLNIWDVGGQQSLRSYWRNYFESTDGLIWVVDSNDVARLDDCRRELHTLLQEERLAGASLLILLNKQDLSGALPPGEIERHLGIDIIRKGKRHVYLCACSAKTGAGLLQGMEWIVQDVSSRMYFAG
Protein: ATP synthase subunit b, chloroplastic (ATP synthase F(0) sector subunit b) (ATPase subunit I) (P56759)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01398}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01398}.
Interaction partners:
- ATP synthase subunit beta, chloroplastic
- ATP synthase subunit alpha, chloroplastic
- ATP synthase epsilon chain, chloroplastic
- ATP synthase subunit alpha
- ATP synthase subunit c, chloroplastic
- ATP synthase subunit a, chloroplastic
- ATP synthase subunit O, mitochondrial
- ATPase, F1 complex, OSCP/delta subunit protein
- ATP synthase subunit a.
- ATP synthase subunit delta, chloroplastic
Sequence:
MKNLTDSFVYLGHWPSAGSFGFNTDILATNPINLSVVFGVLIFFGKGVLNDLLDNRKQRILNTIRNSEELREGAIQQLENARARLRNVETEADKFRVNGYSEIEREKLNLINSTYKTLKQLENYKNETILFEQQRTINQVRERVFQQALQGAIGTLNSCLSNELHLRTINANIGMFGTMKEITD
Protein: Inactive poly [ADP-ribose] polymerase RCD1 (Protein RADICAL-INDUCED CELL DEATH 1) (Q8RY59)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inactive ADP-ribosyltransferase that functions with SRO1 to regulate oxidative stress, hormonal and developmental responses. Required for embryogenesis, vegetative and reproductive development, and abiotic stress responses. May regulate several stress-responsive genes. Seems to play a larger developmental role than SRO1. Does not bind NAD in vitro.
Subcellular location: Nucleus matrix {ECO:0000269|PubMed:16926493, ECO:0000269|PubMed:19548978}. Note=Speckle-like pattern.
Interaction partners:
- NAC domain-containing protein 13
- ATP synthase subunit 9
- ATP synthase subunit 9, mitochondrial
- Sodium/hydrogen exchanger 7
- ATP synthase subunit a.
- NAC domain-containing protein 46
- Cytochrome c oxidase subunit 1
- NADH dehydrogenase subunit 4L.
- NADH-ubiquinone oxidoreductase chain 6
- NADH-ubiquinone oxidoreductase chain 6
Sequence:
MEAKIVKVLDSSRCEDGFGKKRKRAASYAAYVTGVSCAKLQNVPPPNGQCQIPDKRRRLEGENKLSAYENRSGKALVRYYTYFKKTGIAKRVMMYENGEWNDLPEHVICAIQNELEEKSAAIEFKLCGHSFILDFLHMQRLDMETGAKTPLAWIDNAGKCFFPEIYESDERTNYCHHKCVEDPKQNAPHDIKLRLEIDVNGGETPRLNLEECSDESGDNMMDDVPLAQRSSNEHYDEATEDSCSRKLEAAVSKWDETDAIVVSGAKLTGSEVLDKDAVKKMFAVGTASLGHVPVLDVGRFSSEIAEARLALFQKQVEITKKHRGDANVRYAWLPAKREVLSAVMMQGLGVGGAFIRKSIYGVGIHLTAADCPYFSARYCDVDENGVRYMVLCRVIMGNMELLRGDKAQFFSGGEEYDNGVDDIESPKNYIVWNINMNTHIFPEFVVRFKLSNLPNAEGNLIAKRDNSGVTLEGPKDLPPQLESNQGARGSGSANSVGSSTTRPKSPWMPFPTLFAAISHKVAENDMLLINADYQQLRDKKMTRAEFVRKLRVIVGDDLLRSTITTLQNQPKSKEIPGSIRDHEEGAGGL
Protein: Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) (Q9R0A0)
Organism: Mus musculus (Mouse)
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin (By similarity).
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:12488033}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q642G4}.
Interaction partners:
- Peroxisomal targeting signal 1 receptor
- Peroxisomal membrane protein PEX13
- Peroxisomal biogenesis factor 19
- PEX5-related protein
- Peroxisome assembly protein 12
- Peroxisomal targeting signal 2 receptor
- Peroxisomal ATPase PEX6
- Peroxisome biogenesis factor 10
- Peroxisomal membrane protein 11B
- Peroxisome biogenesis factor 2
Sequence:
MASSEQAEQPNQPSSPPGSENVVPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDLAFQQSGTAADEPSPLGPATPVVPVQPPHLTPQPYSPRGSRWRDYGALAIIMAGIAFGFHQLYKRYLLPLILGGREDRKQLERMAASLSELSGTVAQTVTQVQTTLASVQELLRQQQQKVQELAHELATAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSSSPSSPAAVNHHSSSDISPVSNESTSSSPGKDSHSPEGSTATYHLLGPQEEGEGVLDVKGQVRMEVQGEEEKREDKEDEDDEDDDVSHVDEEDVLGVQREDRRGGDGQINEQVEKLRRPEGASNETERD
Protein: Fibronectin type-III domain-containing protein (Q8BKQ1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MLSSLGCLLLCGSIALALGNAQKLPKGKKPSLKVHINTTSDSILLKFLRPNANVKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVVDAEPKYLIVVRPAPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHDWTLPSHCPSDRFYTIRYREKDKEKKWIFQLCPATETIVENLKPNTVYEFGVKDNIEGGIWSKIFNHKTIVGSKNKVNGKIQSTYDQVHSVPVPRKLIPLTIIKQVIQNVTHRASTKSPDKTPFGGTILVHLIIPGLNESTVKLPTSIMLEISDALKAQLAKNETLALPAESKTPEVEKLAGQPVTVTPESVSRSTKPTLSSALDTAETALGNAKNCLSIPPPPTIEQQ