wanglab/gogpt-training-data huggingface dataset:
Protein: Rrp6p homologue (Q95Z10)
Organism: Trypanosoma brucei
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSGSLPQTKDLVNGAFTLVKEYTKLTADLAEEDYDYHMAFPAFRHQITRHSEAVVSLMDKFCQLLPAKRRVTLSSTGGKLTDPQRAAVMEAADSLLENVDGLLDELKGRRLSAKDQLSVKFGSELQGVVPSSSYSVFNAAGVSVLRPQLTFEHPVDNSPTPFRPVYYDEKGVRHVGEPGVHPFAERIKAVSVPSEQLLLKTETPYLSLVTCPLTFVDTVEDLEALVAVLLNETEIAVDLEHHDFYSYQGFTCLMQISTRTQDFIVDCLKVRANMYLMAPVFLQPNIVKVFHGAREDVRWLQKDFGLYIVNLFDTSIALQNLHMPHSLAFAVDHFCQVKLNKKYQTADWRVRPIPAEMVSYAQQDTHFLLYVYDRLKQLLLNCEARASVGNMLLHVFQESRLLSLERYEKPHLDPDVTYKQALGRSLGGLSSPQLQVAREIFNWRDMAAREADDSPSAVMHISCVLSIATKLPTSANEVLKCCSPVSVAVRTNVMKLLQIVKDAIGSADSLKDGANGDVKPKPLPNVGVALRYMGVHRSMTGTLPSIEQRADPAFTVEDAHVVVRTEPSAWFETMRNVAAILRRKPYYPIALPGHDVVTRMSAVKRAREVEEMKVKGEGEEEEKRVHVDAEEPTVERENSSERGEGMAGPCLQEGLEVKDEVEEIDVPTQKPLELKEGAISLHQQYGTGSANRKKARLGKKNKL
Protein: Polycomb protein sop-2 (H8P172)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSSNLTSNEMSSTSAIVEPPEAVKGNERDKSTRRSTSQVVRPEKHEVENALEDQCSSSSLPKEAQYYAKLDKKLEGKDPRSQFYEAVRLSADIFAHKFEKAVCSRQTFEPTNSIIKVLNTAEEEMLHEKVVPLPVSSKLQYYLNRGRYDTIFDRDEQLQRTADPMADEPDHVEKRVTSILEQASREMEEGEVEPVFYDGSDEDQELPIDLGAMRNLQRTNKFAARSSRMAARRGGRPGYRGAFRGAARGAPSRRPAPAAEVAPETPVAAPMAPAAPAAPATPEAAPAAEVMDTSIATEMPQESAVDLSNVSAATEMDTSKEGEASRPTSEKKKFQKIRTTEMDRLMSMDLGPKDGGRVGELGHMWPESRRRPAAPLPETPAAQPRKSLPRRAAEKKKPEDSDAAEEQEVEMEVDNDASTSTPRNARGGRGGGNRRGSRRGQKRTSGGSGKLVEPKKEPVDEPAEKIPKRSEAAPEVPATATTKEAPPSTSSSPPDAPATPATPASSDSRDSPRKIRAMIFSLTGSPPESETPPVLQQEQVISTAAPTAGRHPNIIQQVPHINRIPPQPLRRLTAPQAPPASQPEEPPVQQTVPVVKVELASAPAPIVRDPQSTEPVPPAMPTLVENNHEATLILPPNKTSDYTRWNAQDLINWVRLLITNNVDSTIAIMVREEFDGETLACLVLDDDFRKEVPIPYGHYKKMKIYGTEVLNHYRTEKYQADLRKFHEELAAWKAQQR
Protein: Uncharacterized protein (Q57V91)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- C-type lectin domain-containing protein
- CRAL-TRIO domain-containing protein
Sequence:
MATNKGITFQVIVGIAALLSAFIIIMICIIVIERRRLRNARARQNVQLDPAALNLTGEQLRHRLIRHAVDLLLADNYVCEGITLTSTVGVTEVLADRELRSTRGRPYFITTANGRRATISQVVQQTRASGQAPDSPPGPALMELLEKLQHARRAEPVPNEALCKQVEELMERLIKLEEANQRKDMKTDADEVYGKAAQYATNPANKCVRHVMNAVGVGRSLVASR
Protein: Ligand-binding SRPBCC domain-containing protein (O06816)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
Sequence:
MVGYAEPVLIERQSVVAAPAEQVWQRVVTPEGINDELRPWMTMSVPRGAKGMTVDTVPIGAPIGRAWLRLFGVLPFDYDRLSIAELEPGRRFREDSTMLSMRQWQHERTVTPEGDTKTIVRDRITFQTRAGLRFAAPLIAAGLRALFGHRHRRLQRHFAQG
Protein: Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.1) (Q9D939)
Organism: Mus musculus (Mouse)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Sulfonates p-nitrophenol, a small phenolic compond. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O46503}. Lysosome {ECO:0000250|UniProtKB:Q9WUW8}. Mitochondrion {ECO:0000250|UniProtKB:Q9WUW8}.
Interaction partners:
- Sulfotransferase 1A1
Sequence:
MALTPELSRQTKLKEVAGIPLQAPTVDNWRQIQTFEAKPDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCRRTIIQHRHPFIEWARPPQPSGVDKANEMPAPRILRTHLPTQLLPPSFWTNNCKFLYVARNAKDCMVSYYHFYRMSQVLPEPGTWDEYFETFINGKVSWGSWFDHVKGWWEIRDKYQILFLFYEDMKRNPKHEIQKVMQFMGKNLDEDVVDKIVLETSFEKMKENPMTNRSTAPKSILDQSISPFMRKGTVGDWKNHFTVAQNERFDEIYKQKMGRTSLNFSMEL
Protein: BARP protein (Q38CW2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSITFNNLWLLLTVLCTARIRADFIGEECLDIVSYPSADVVRILCHVAGQLRGLSQTVSSAVETAAAASSKAFEAKVQAEEAVELAESRGLNVTKAKEAAVRATHAAEAAALAASNLAFAAANIAAVPWSQPISDSMLHKLALCDHVDEYVREAAKKCTKKAKNVTAQSLNEVLKAFEKLFSEVNALQSLRHNIAEFHKDLKSLEDHVEDIVRAQKNAEDAAAETNKIAAPDHEVGGNKEETPSQQPDTNQDQQANEKPEANQTAGTNTGPLGNSVASPEGSVLLLMAGLFLGSVL
Protein: Transmembrane and ubiquitin-like domain-containing protein 2 (Q71RG4)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- E3 ubiquitin-protein ligase RNF185
- Transmembrane and ubiquitin-like domain-containing protein 1
- Membralin
- Erlin-1
- Erlin-2
Sequence:
MISRHLQNNLMSVDPASSQAMELSDVTLIEGVGNEVMVVAGVVVLILALVLAWLSTYVADSGSNQLLGAIVSAGDTSVLHLGHVDHLVAGQGNPEPTELPHPSEGNDEKAEEAGEGRGDSTGEAGAGGGVEPSLEHLLDIQGLPKRQAGAGSSSPEAPLRSEDSTCLPPSPGLITVRLKFLNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGRLLQDPARTLRSLNITDNCVIHCHRSPPGSAVPGPSASLAPSATEPPSLGVNVGSLMVPVFVVLLGVVWYFRINYRQFFTAPATVSLVGVTVFFSFLVFGMYGR
Protein: F1N19.7 (Glutaredoxin family protein) (Putative peptide transporter protein) (Q9SGW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cytochrome P450 71B10
- Glutathione S-transferase 3, mitochondrial
- Dirigent protein 12
Sequence:
MGCTSSKQAKANVVADVYKPPPSSFAVFDVNAIQEPWLKFEHEDDEKPPRSTVFDRLDEDDDDDDDDGDDAPKTWEEVSKSLETKLKPAAVKPPEVDSVKPPATPPRRLPRKSASFHTLDELEVRAKRSIAAQIPTTMVKLKRTESMSKLRPESDDRTESTQSSYSGPRSVKENIFVKRDRERREKEGNKKPVMNWDPLREFPEKCPPGGGEGLIVYTTSLQGVRRTYEDCMRVRAIMEQQGVVVDERDVSLDAGVLSELKELLQDEASVAPPRVFVKGRYLGGAAEVTAMNENGKLGRVLRWARVERVGEEGRLTCEGCGGARWLPCFECGGSCKVAAVGAAKGERWERCVKCNENGLIRCPVCFVN
Protein: Probable enoyl-CoA hydratase EchA18 (Enoyl hydrase) (Unsaturated acyl-CoA hydratase) (Crotonase) (O50402)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Putative amidase AmiD
- Probable enoyl-CoA hydratase EchA18.1
- 3-hydroxybutyryl-CoA dehydrogenase
- Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3
- Probable acyl-CoA dehydrogenase FadE4
- Probable acyl-CoA dehydrogenase FadE1
- Probable acyl-CoA dehydrogenase FadE2
- Possible acyl-CoA dehydrogenase FadE19
- Probable acyl-CoA dehydrogenase FadE13
- Acyl-CoA dehydrogenase FadE7
Sequence:
MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVALITLSHPQAQNALNLASWRRLKRLLDDLAGESGLRAVVLRGAGDKAFAAGADIKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCIATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLFSGELIGIEEAARW
Protein: Acetylcholine receptor subunit alpha-type unc-63 (Levamisole-resistant protein 7) (Uncoordinated protein 63) (Q9N587)
Organism: Caenorhabditis elegans
Function: Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q27218}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q27218}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Acetylcholine receptor subunit beta-type unc-29
- Acetylcholine receptor subunit alpha-type unc-38
- Acetylcholine receptor subunit beta-type lev-1
- AcetylCholine Receptor
- Protein unc-50
- Acetylcholine receptor subunit beta-type acr-3
- Resistance to inhibitors of cholinesterase protein 3
- CUB domain-containing protein
- AcetylCholine Receptor
- Acetylcholine receptor subunit beta-type acr-2
Sequence:
MGPNDHGFAYILIFLLLSPPTHANRDANRLFEDLIADYNKLVRPVSENGETLVVTFKLKLSQLLDVHEKNQIMTTNVWLQHSWMDYKLRWDPVEYGGVEVLYVPSDTIWLPDVVLYNNADGNYQVTIMTKAKLTYNGTVEWAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVDLQHRDKHLEKEIEEDVEGVDGPTKEIVWVVDRGIDLSDYYPSVEWDILNVPGKRHSKRYPCCESPFIDITYEIHLRRKTLFYTVNLIFPSVGISFLTALVFYLPSDGGEKISLCISILISLTVFFLLLVEIIPSTSLVIPLIGKYLLFTMVLVTLSVVVTVVTLNVHYRSPTTHTMPKWMKRLFVDFLPKYLLMTRPQPPGHHSKPNRKFDSRASTFSIGVNHVLGQNSELLSPGLNSNREESSFTLPRDNSPVRSAVESVAYIADHLKNEEDDKQVIEDWKYISVVMDRIFLITFTFACAFGTVVIIARAPSIYDNTPALA
Protein: Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25) (K7ENE3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTVMEAQESPLFNNVKLQRKLPVESIQIVLEELRKKGNLEWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTNGEDTEDEEFHGLDEATLLRALQAL
Protein: AT18705p (EG:BACR37P7.5 protein) (Q9V3G9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO10752p1
- Protein phosphatase
- inositol-phosphate phosphatase
- EG:BACR37P7.8 protein
- FI17329p1
- Cytosol aminopeptidase
- AT13777p
- Cytosol aminopeptidase
- 10 kDa heat shock protein, mitochondrial
- Male-specific sperm protein Mst84Dc
Sequence:
MGKKGKGKKGKKPAAVVAPIEAPPCPPCPEPPKQMQPLDACPESSGPHDVLRAQPNHYPALLRIPETMAVVGSENGCYDSICKLLRAGFRCAERVFVMAPWGNYVVFRYHNNNDFIYFLFDGCTCDVNRFRYLDLSCGTAGFLFFDNMHDVISYIIQSRKTRLYLENLNKIAIDQIVEEYGAVTYTQKAKCMRFA
Protein: Eukaryotic initiation factor 4A-1 (eIF-4A-1) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) (DEAD-box ATP-dependent RNA helicase 4) (AtRH04) (P41376)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P10081}.
Interaction partners:
- Protein mago nashi homolog
- RNA-binding protein Y14
- THO complex subunit 4B
- Eukaryotic translation initiation factor isoform 4G-2
- Eukaryotic translation initiation factor 4G
- Eukaryotic translation initiation factor isoform 4G-1
- Eukaryotic initiation factor 4A-2
- Eukaryotic initiation factor 4A-3
- Elongation factor 2
- Eukaryotic initiation factor 4A-III homolog
Sequence:
MAGSAPEGTQFDARQFDQKLNEVLEGQDEFFTSYDDVHESFDAMGLQENLLRGIYAYGFEKPSAIQQRGIVPFCKGLDVIQQAQSGTGKTATFCSGVLQQLDFSLIQCQALVLAPTRELAQQIEKVMRALGDYLGVKVHACVGGTSVREDQRILQAGVHVVVGTPGRVFDMLKRQSLRADNIKMFVLDEADEMLSRGFKDQIYDIFQLLPPKIQVGVFSATMPPEALEITRKFMSKPVRILVKRDELTLEGIKQFYVNVEKEEWKLETLCDLYETLAITQSVIFVNTRRKVDWLTDKMRSRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINFDLPTQPENYLHRIGRSGRFGRKGVAINFVTRDDERMLFDIQKFYNVVVEELPSNVADLL
Protein: Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (P43431)
Organism: Mus musculus (Mouse)
Function: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:1350290, ECO:0000269|PubMed:34374750}.
Interaction partners:
- Interleukin-12 receptor subunit beta-2
- Interleukin-12 subunit beta
- Interleukin-27 subunit beta
- Interleukin-12 receptor subunit beta-1
- Interleukin-23 subunit alpha
- Interferon gamma receptor 1
- Interleukin-27 receptor subunit alpha
- Interleukin-23 receptor
- Interleukin-27 subunit alpha
- Interleukin-2 receptor subunit alpha
Sequence:
MCQSRYLLFLATLALLNHLSLARVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSA
Protein: DNA replication complex GINS protein SLD5 (GINS complex subunit 4) (Q7ZT48)
Organism: Xenopus laevis (African clawed frog)
Function: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Subcellular location: Nucleus {ECO:0000269|PubMed:12730133}. Chromosome {ECO:0000269|PubMed:12730133}. Cytoplasm {ECO:0000250|UniProtKB:Q99LZ3}.
Interaction partners:
- DNA replication complex GINS protein PSF2
- DNA replication complex GINS protein PSF1
- Uncharacterized protein.
- DNA helicase
- Uncharacterized protein.
- DNA replication licensing factor MCM4
- DNA replication licensing factor MCM7
- DNA helicase
- DNA replication licensing factor MCM2
- DNA helicase
Sequence:
MEDELALSDQGSDEDEEVLTPAELINKLEEAWLNEKFAPELLESKSEVVECVMEQLNHMEQNLHRAKPGDLKISFHHMEIERIRYMLSSYLRSRMLKIEKFFPHILEKEKSRGEGEPPHLSPEEFAFAKEYMTNTETLLKSVALRHMPPNLQTVDLLKSVPKPNLDSFVFLRVKEEQNNILVEPETDEQSEYAIDMEVGSQHLIRYRTIAPLVASGAVKLI
Protein: Klf7l protein (Krueppel-like factor 7b) (Kruppel-like factor 7 (Ubiquitous), like) (Kruppel-like factor 7b) (Q5TYN4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- cAMP-responsive element-binding protein 1b.
Sequence:
MDVLANYSIFQELQLVHDTGYFSAMPSLEENWQQTCLELERYLQTEPKRLSELFDEELDCLLTPAFMKGDSDEDLMDPLLPSLSDEPSPPPLLVSLPKTLHTPANTKSTDAGLKEASGGVNPAQLNAVTSLTPPSSPELGRHLVKPTQTLTATADGTLTLKLVAKKVGLGAAKLVATHSIPSPPNRGTQSDGEGGLGTVGGGDIPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI
Protein: Predicted gene, 20835 (Predicted gene, 20855) (Predicted gene, 20894) (Predicted gene, 20916) (Predicted gene, 20920) (Predicted gene, 21317) (Sycp3 like Y-linked) (A0A087WSR0)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MRRMALKKLKVIPKEGYLLLLDFDDEDDDIKVSEEALSEVKSPAFDKNENISPQAEADEDMGDEVDSMLDKSEDDIYKTLHIKRKWMETYVKESFKGSNQKLERFCKTNERERKNINNKFCEQYITTFQKSDMDVQKFNEEKEKSVNSCQKEQQALKLSKCSQNQTLEAVKEMHEKSMEVLMNLGTKN
Protein: Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) (Q8IVF5)
Organism: Homo sapiens (Human)
Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q6ZPF3}. Perikaryon {ECO:0000250|UniProtKB:Q6ZPF3}.
Interaction partners:
- Guanine nucleotide exchange factor MSS4
- SR-related and CTD-associated factor 8
Sequence:
MGNSDSQYTLQGSKNHSNTITGAKQIPCSLKIRGIHAKEEKSLHGWGHGSNGAGYKSRSLARSCLSHFKSNQPYASRLGGPTCKVSRGVAYSTHRTNAPGKDFQGISAAFSTENGFHSVGHELADNHITSRDCNGHLLNCYGRNESIASTPPGEDRKSPRVLIKTLGKLDGCLRVEFHNGGNPSKVPAEDCSEPVQLLRYSPTLASETSPVPEARRGSSADSLPSHRPSPTDSRLRSSKGSSLSSESSWYDSPWGNAGELSEAEGSFLAPGMPDPSLHASFPPGDAKKPFNQSSSLSSLRELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSFTLPCRKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGLNTDVQGSSQASAFLWSGGSTQILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTENIETSTETAESSSESLSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTVQKERKLELVARRKWKQYWVTLKGCTLLFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLFQATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQLSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPSKLALGRLGILSVSSFHALVCSRDDSALRKRTLSLTQRGRNKKGIFSSLKGLDTLARKGKEKRPSITQVDELLHIYGSTVDGVPRDNAWEIQTYVHFQDNHGVTVGIKPEHRVEDILTLACKMRQLEPSHYGLQLRKLVDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVCDFGFAVTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEALFSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKKNTANDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRSLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFSVQSLTSVVSEECFYETESHGKS
Protein: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (EC 5.3.1.16) (5-proFAR isomerase) (BBM II isomerase) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) (Protein ALBINO AND PALE GREEN 10) (Protein HISTIDINE BIOSYNTHESIS 3) (O82782)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Histidine biosynthesis bifunctional protein hisIE, chloroplastic
- Imidazole glycerol phosphate synthase hisHF, chloroplastic
- Histidinol dehydrogenase, chloroplastic
- Imidazoleglycerol-phosphate dehydratase 2, chloroplastic
- ATP phosphoribosyltransferase 2, chloroplastic
- Imidazoleglycerol-phosphate dehydratase 1, chloroplastic
- ATP phosphoribosyltransferase 1, chloroplastic
- Histidinol-phosphate aminotransferase 1, chloroplastic
- Helicase protein with RING/U-box domain-containing protein
- Histidinol-phosphate aminotransferase 2, chloroplastic
Sequence:
MRTLSSQLYSNGGLTWFQKKNQSSLFIKHLRVSKPSRVQLISAVQFRPCIDIHKGKVKQIVGSTLRDLKEDGSVLVTNFESDKSAEEYAKMYKEDGLTGGHVIMLGADPLSQAAAIGALHAYPGGLQVGGGINSENCMSYIEEGASHVIVTSYVFNNGKIDLERLKDIVSIVGKQRLILDLSCRKKDGRYAIVTDRWQKFSDVILDEKSLEFLGGFSDEFLVHGVDVEGKKLGIDEELVALLGNYSPIPVTYAGGVTVMDDVERIKDAGKGRVDVTVGSALDIFGGNLPYKDVVAWHHKQHSLH
Protein: Heavy metal-associated isoprenylated plant protein 20 (AtHIP20) (AtHIPP20) (Q9C9A3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Heavy-metal-binding protein. Binds cadmium. May be involved in cadmium transport and play a role in cadmium detoxification.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9SZN7}.
Interaction partners:
- Heavy metal-associated isoprenylated plant protein 12
- Heavy metal-associated isoprenylated plant protein 3
- Heavy metal-associated isoprenylated plant protein 16
- Heavy metal-associated isoprenylated plant protein 39
- Nudix hydrolase 9
- Gamma-glutamylcyclotransferase 2-3
- Heavy metal-associated isoprenylated plant protein 6
- At5g42440
- Rhamnogalacturonan I rhamnosyltransferase 1
- Heavy metal-associated isoprenylated plant protein 10
Sequence:
MGALDSLSEYISDYFRVTRKRRKRKVMQTVNIKVKMDCDGCERRVKNAVSSMKGVKSVEVNRKIHKVTVSGYVEPKKVLKRIERTGKKAEIWPYVPYNMVAYPYAVGTYDKKAPAGYVRKSEQSQLQLLPGAPENHYISLFSDENPNACTVM
Protein: Ammonium transporter 1 (Q9BLG4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Ammonium transporter that mediates the excretion of ammonium. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19108721}; Multi-pass membrane protein {ECO:0000269|PubMed:19108721}. Endosome membrane {ECO:0000269|PubMed:19108721}; Multi-pass membrane protein {ECO:0000269|PubMed:19108721}. Lysosome membrane {ECO:0000269|PubMed:19108721}; Multi-pass membrane protein {ECO:0000269|PubMed:19108721}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:19108721}; Multi-pass membrane protein {ECO:0000269|PubMed:19108721}.
Interaction partners:
- Cytochrome b5 reductase
- Cytochrome b5 heme-binding domain-containing protein
- Acetyl-CoA hydrolase
Sequence:
MVAGEIIKGVAAEITNGSSSSVVQKYLDCANQVAPDPGNTTWVLLSTILVLGMMPALAFFEAGLLRSKNTLSIITQIMSGIVVLTVMWQAFGYSLTFGPDQKGIIGNLDHAFLINVSYDDCSPNAPNIPAAAYAFFMMMFANITPLLMTGAFAERVKFKAFIALTVAWEIIVFYPVAHWIWGGGWLHKYFGVLDFAGGIVIHTSAGVSALVIALYVGRRKDFEKYGGEFPPSNLPLATIGAALLWMGWFGFNAGSALAAGNIATSAVASTQIGGSFSAIVWIILSAAKGKPNTVSVINGVIAGLAGITPASGYINSQYSIGLGICLGLASYYSVVLLKHKLHIDDALDVSSVHGLTGIIGSLAIGFCAELSVNPNGANGAFYGNPKLIGTQLLGVVSVAVWAAAWTWVLLKIIDATIGVKIDESEEELGLDLVEHGEFAYHNISLQGNENHYSSVINSHDFFK
Protein: Transcription initiation factor IIB (General transcription factor TFIIB) (O13749)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- TATA-box-binding protein
- Transcription initiation factor IIF subunit beta
- DNA-directed RNA polymerase II subunit rpb1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- Transcription initiation factor IIE subunit alpha
- DNA-directed RNA polymerase II subunit rpb7
- DNA-directed RNA polymerase II subunit RPB3
- Transcription initiation factor IIF subunit alpha
- DNA-directed RNA polymerase II subunit rpb4
Sequence:
MNAPSFTGLPTSMLSVKMICSECREDPPNLVEEFSSGDTVCGSCGLVLGDRIIDTRSEWRTFSNSDEASGDPSRVGKVANPLLNGSQLDTTISSYDGAGAMLAKAQGRSVQVRGEKNLLTAYKEIGAMCDAISLPKVIADTAKQLYKRVDDHKALKGKSSQSIIAACIYIACRQGKVPRTFMEICTLTNVPKKEIGRVYKTLQRMLTEGGALHNSVDALKGHEYIQSSSTSAEDLMVRFCNRLMLPMSVQSAAAELARRAGLQGTLAGRSPISIAASGIYMISALMGYPKTPKEISEVTGVSDSTIRIAYKLLHAERKELIDPKWIANKAGNMDAMLPKP
Protein: DNA-directed RNA polymerase subunit Rpo2 (EC 2.7.7.6) (DNA-directed RNA polymerase subunit B) (P11513)
Organism: Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (Ref.4). This subunit is involved in DNA promoter recognition (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:B8YB55}.
Interaction partners:
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein uL5
- DNA-directed RNA polymerase subunit Rpo1N
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS8
- DNA-directed RNA polymerase subunit Rpo5
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS13
Sequence:
MLDTESRWAIAESFFKTRGLVRQHLDSFNDFLRNKLQQVIYEQGEIVTEVPGLKIKLGKIRYEKPSIRETDKGPMREITPMEARLRNLTYSSPIFLSMIPVENNIEGEPIEIYIGDLPIMLKSVADPTSNLPIDKLIEIGEDPKDPGGYFIVNGSEKVIIAQEDLATNRVLVDYGKSGSNITHVAKVTSSAAGYRVQVMIERLKDSTIQISFATVPGRIPFAIIMRALGFVTDRDIVYAVSLDPQIQNELLPSLEQASSITSAEEALDFIGNRVAIGQKRENRIQKAEQVIDKYFLPHLGTSPEDRKKKGYYLASAVNKILELYLGRREPDDKDHYANKRVRLAGDLFTSLFRVAFKAFVKDLVYQLEKSKVRGRRLSLTALVRADIITERIRHALATGNWVGGRTGVSQLLDRTNWLSMLSHLRRVVSSLARGQPNFEARDLHGTQWGRMCPFETPEGPNSGLVKNLALLAQVSVGINESVVERVAYELGVVSVEDVIRRISEQNEDVEKYMSWSKVYLNGRLLGYYEDGKELAKKIRESRRQGKLSDEVNVAYIATDYLNEVHINCDAGRVRRPLIIVNNGTPLVDTEDIKKLKNGEITFDDLVKQGKIEFIDAEEEENAYVALNPQDLTPDHTHLEIWPSAILGIIASIIPYPEHNQSPRNTYQSAMAKQSLGLYASNYQIRTDTRAHLLHYPQMPLVQTRMLGVIGYNDRPAGANAILAIMSYTGYNMEDSIIMNKSSIERGMYRSTFFRLYSTEEVKYPGGQEDKIVTPEAGVKGYKGKDYYRLLEDNGVVSPEVEVKGGDVLIGKVSPPRFLQEFKELSPEQAKRDTSIVTRHGENGIVDLVLITETLEGNKLVKVRVRDLRIPEIGDKFATRHGQKGVVGILIDQVDMPYTAKGIVPDIILNPHALPSRMTIGQIMEAIGGKYAALSGKPVDATPFLETPKLQEMQKEILKLGHLPDSTEVVYDGRTGQKLKSRILFGIVYYQKLHHMVADKMHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGFGTAMLIKDRLLDNSDKAVVYICDQCGYVGWYDRSKNRYVCPVHGDKSVLHPVTVSYAFKLLIQELMSMVISPRLILGEKVNLGGASNE