wanglab/gogpt-training-data huggingface dataset:
Protein: Conidiogenone synthase (Bifunctional terpene synthase PrDS) (BFTS PrDS) (Conidiogenone biosynthesis cluster protein PrDS) (Diterpene synthase PrDS) (DS) [Includes: Terpene cyclase (EC 4.2.3.-); Geranylgeranyl diphosphate synthase (GGDP synthase) (GGS) (EC 2.5.1.29)] (W6QAE7)
Organism: Penicillium roqueforti (strain FM164)
Function: Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of conidiogenone, a diterpene known to induce the conidiation. The bifunctional terpene synthase PrDS converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into deoxyconidiogenol. The C-terminal prenyltransferase (PT) domain of PrDS catalyzes formation of GGPP, whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GGPP into deoxyconidiogenol. The cytochrome P450 monooxygenase PrP450 then catalyzes two rounds of oxidation to furnish conidiogenone.
Interaction partners:
- Diphosphomevalonate decarboxylase
- Multifunctional tryptophan biosynthesis protein
- isopentenyl-diphosphate Delta-isomerase
- Protein farnesyltransferase subunit beta
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Probable hexaprenyl pyrophosphate synthase
- Di-trans-poly-cis-decaprenylcistransferase-like
- ditrans,polycis-polyprenyl diphosphate synthase [
- Squalene synthase
- Squalene synthase
Sequence:
MGETIADVYAESIDPEIYANNPAYSSLFTPYIHKQTIIADHVSVQCHIDLNGIDAVGSKFGNLNAHAGNFTSLCAPNCLPERLALVAYTVEYAFLHDDETDNAADQEALLLENKMLHQAINQSSMTSVSNRVSAKAQRKSEVQAKIAAEYLRLDPVFGEFFLKAWQTFTASVQDVRSLEFPSLDDYLEFRIVDAAADWTLYNFRWGSGITLTPEEEKIADPMSYVAYAELCLVNDLFSWDKEYDAHVKSNGEVPLVNAVHIVAVTQGLTHCAAKAVVQAEIRAHEERFCYLKEQYKATASPSDSILSWLKLLEHSMAGNWVWSLCVPRYFKVERNPYKDHLEKFGSEAVRVLTPEEHLRDSKQEINGTKEIELQEPKSNNTAESDVLAKYTSGYPTIDEPVLNPYTYINSLPSKNVRQTMIAALNSWYKVPVKSLLIIEGAVNFLHNSSLLLDDIQDGSVLRRGRPVAHQIFGVGQTINTATYLMNEALYLVQMLSPSAVLVYTDEMRNLQLGQGRDLHWSYHTHVPTPAQYISMVDGKTGGLFRLISRLMRSEATVNRDLDISQFATLLGRHFQIRDDYQNLQSDDYTKNKGFCDDLDEGKLSFPIILSMQSPGFSNTALSSVFKGSQKGETLSPEMKQYILEEITARGAFSQTKAVLRKLHIELLRLLMETEQKAGGIENWALRLLIMKLDLGDEKKKEAHKSDSAWKVNQRRAWKGSQKNGRPIDKACFLRAMEEASQK
Protein: Non-structural maintenance of chromosomes element 1 (Non-SMC element 1) (EC 2.3.2.27) (Q53EK2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:12966087, ECO:0000269|PubMed:16823372}.
Interaction partners:
- Non-structural maintenance of chromosome element 3
- E3 SUMO-protein ligase nse2
- Structural maintenance of chromosomes protein 6
- Non-structural maintenance of chromosome element 4
- Structural maintenance of chromosomes protein 5
- Non-structural maintenance of chromosome element 5
- Non-structural maintenance of chromosome element 6
- Nucleolar protein dnt1
- Uncharacterized protein C18G6.01c
- Structural maintenance of chromosomes protein 3
Sequence:
MEKERQDGLSDKHKFILQYIMCRTAGVDNEQVRELVQEQYGETATVEDVINELNNSLHNFDFKIKRVQDQLDGRLTLHFQNLSGDPVSQMATPYPPVQIELMRKIIEWIMKCDDYQYSLTTLQIQKLSRKEMGLAPSVIESHLHTFERDGWLRQREGIWTFTNHALAELDAYLHNEYESNLYECNACREIVIAGYVCDCGYCLHVYCCKHLAHVNCINCNTPWANATVIGRW
Protein: FI22203p1 (Pericentrin-like protein, isoform C) (Q400N1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
Interaction partners:
Sequence:
MQTAEVSKMFQGPKIPLRELQHERDTLQGRMEEQTQRISTLQNRLEEQRQRAEQLHRTGTSDLNTRVHELQGEVQNLYEQLAARDKQMANMRQQLQRSKEEITRLETEVEVRTQPDRSLVNKLQAEVQQKGAEIVKLKDKIRTEMINRLAIPDLMETMLADKNDEIDHLRDQLEAKEKELQASQQEASQISSPSGAAGKQEGSGGKLSARTLSDIGSITEFPEPDVERRAAMRSLTALQMSEGAGGFLHQTMETSKEAVANLTHKRTDDLSGFIVPYPVNTFEHPHYFQALGVTAQSTDGLTPGLVPRQINFSNLTEDSKLKTTSLLMHTPELPRPTTPPEIHQLRVKLSDLQTEKQRQQSELEKKLQDLQKELEQEKEKLSRQAQTLQSYEESEAKYRLRIENLESKVLETAAQAASDRENLRKELNCVSAAHEQCENAAAARKRELEKLNSEVKVKADQLHAALRRCADLELQVLTLERDLERLKNSDNSSKQYSVDEIAQQVEKELNYSAQLDSNILKAIESEEENNLDKKLQKGVQTEEETLPGTGNGTDDENFTGERELLNQLEALRAQLAVEREQCEAMSKELLGEKQHSQDIQEQDVIIIEAMRKRLETALDAEDELHKQLDQERERCERLQTQLTSLQRAESRRNSSLLLKSPGDSPRKSPRADFESELGDRLRSEIKLLVAQNERERERSADAQRSSERERQRYEKELQERVAYCERLKQEMEKLSRDKESAETELEHFNERLTLQASEIESLEARLVTLQEAETRRANTRTRQHQENVKLQAEIHELKSKLLAAEAARDCLDQKVTQLRFDVSRSGQREAKLAEALAQANDRLAHSTDDNVPAQFMQKMKEINALLAENTQENRQMAETVQFLVGERIALQKKCEELGGAGNTNVTELEERCRQLIGRYLRVESHRKALVYQKRYLKLTLEGYQASEQLALQNLRGGAEQPPQRNIKKKFKTVALAIIAIQRIKYIGRIWHTGKRIVSKSVFTITQQRSPGLNLNVAPPQSPLPGPNSNLPTNNNNLMGRLSYAPLSPPMVNFSTVQPIMLPSDFTLQAPTTSLQTTIANNNSENTLPSLARLDWPTMQKPKRAHARHH
Protein: Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic (AK-HD 2) (AK-HSDH 2) (Beta-aspartyl phosphate homoserine 2) [Includes: Aspartokinase (EC 2.7.2.4) (Aspartate kinase); Homoserine dehydrogenase (EC 1.1.1.3)] (O81852)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Homoserine kinase
- aspartate-semialdehyde dehydrogenase
- Probable cystathionine gamma-synthase 2
- Cystathionine gamma-synthase 1, chloroplastic
- 4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic
- 4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic
- Cystathionine beta-lyase, chloroplastic
- Phosphoserine phosphatase, chloroplastic
- Argininosuccinate synthase, chloroplastic
- Homoserine kinase, putative / HSK
Sequence:
MATLKPSFTVSPPNSNPIRFGSFPPQCFLRVPKPRRLILPRFRKTTGGGGGLIRCELPDFHLSATATTVSGVSTVNLVDQVQIPKGEMWSVHKFGGTCVGNSQRIRNVAEVIINDNSERKLVVVSAMSKVTDMMYDLIRKAQSRDDSYLSALEAVLEKHRLTARDLLDGDDLASFLSHLHNDISNLKAMLRAIYIAGHASESFSDFVAGHGELWSAQMLSYVVRKTGLECKWMDTRDVLIVNPTSSNQVDPDFGESEKRLDKWFSLNPSKIIIATGFIASTPQNIPTTLKRDGSDFSAAIMGALLRARQVTIWTDVDGVYSADPRKVNEAVILQTLSYQEAWEMSYFGANVLHPRTIIPVMRYNIPIVIRNIFNLSAPGTIICQPPEDDYDLKLTTPVKGFATIDNLALINVEGTGMAGVPGTASDIFGCVKDVGANVIMISQASSEHSVCFAVPEKEVNAVSEALRSRFSEALQAGRLSQIEVIPNCSILAAVGQKMASTPGVSCTLFSALAKANINVRAISQGCSEYNVTVVIKREDSVKALRAVHSRFFLSRTTLAMGIVGPGLIGATLLDQLRDQAAVLKQEFNIDLRVLGITGSKKMLLSDIGIDLSRWRELLNEKGTEADLDKFTQQVHGNHFIPNSVVVDCTADSAIASRYYDWLRKGIHVITPNKKANSGPLDQYLKLRDLQRKSYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGICSGTLSYLFNNFVGDRSFSEVVTEAKNAGFTEPDPRDDLSGTDVARKVIILARESGLKLDLADLPIRSLVPEPLKGCTSVEEFMEKLPQYDGDLAKERLDAENSGEVLRYVGVVDAVNQKGTVELRRYKKEHPFAQLAGSDNIIAFTTTRYKDHPLIVRGPGAGAQVTAGGIFSDILRLASYLGAPS
Protein: Lim3, isoform A (Q9VJ02)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MELLKLMMFKSDFLSNGKCDDRVPPINLSQLPEFLLSTIPKCGGCHELILDRFILKVLERTWHAKCLQCSECHGQLNDKCFARNGQLFCKEDFFKRYGTKCSACDMGIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRDYEEAKAKGLYLDGSLDGDQPNKRPRTTITAKQLETLKTAYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKRLKKDAGRTRWSQYFRSMKGNCSPRTDKFLDKDELKVDYDSFSHHDLSNDSYSTVNLGLDEGASPHSIRGSYMHGSSSPSQYPPSSRSPPPVGQGHTFGSYPDNIVYTNIDQAVGSSLHASKAHHRLHSSNNVSDLSNDSSPDQGYPDFPPSPDSWLGDSGSTNTTSANNNANNNSSSSHNNNNSSGGGSGGVSVSTAPNPSAPGVHY
Protein: Cell division protein FtsZ homolog 2-1, chloroplastic (AtFtsZ2-1) (Plastid division protein FTSZ2-1) (O82533)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Exhibits GTPase activity which converts GTP ligands to GDP. Component of the plastid division machinery consisting in a binary fission accomplished by the simultaneous constriction of the FtsZ ring on the stromal side of the inner envelope membrane, and the ARC5 ring on the cytosolic side of the outer envelope membrane. Required for plastid division in a dose-dependent manner. In the vegetative shoot apex, at the shoot apical meristem (SAM), where the proplastid-to-chloroplast transition takes place, major contributor of plastid division in the L1 and L3 layers and contributes equally with FTSZ1 in the L2 layer.
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:22823492, ECO:0000269|PubMed:29769312}. Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:18431481}; Peripheral membrane protein. Note=Forms a contractile ring at the chloroplast midpoint that coaligns with FTSZ1 rings (PubMed:18431481, PubMed:22823492, PubMed:25731613, PubMed:29769312). Exhibits a dynamic trunover in FtsZ ring facilitated by ARC3-mediated destabilization (PubMed:25731613). {ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:22823492, ECO:0000269|PubMed:25731613, ECO:0000269|PubMed:29769312}.
Interaction partners:
- Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6, chloroplastic
- Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 3
- Dynamin-like protein ARC5
- Epimerase family protein SDR39U1 homolog, chloroplastic
- Plastid division protein PDV2
- Plastid division protein PDV1
- Cell division topological specificity factor homolog, chloroplastic
- Dynamin
- YlmG homolog protein 2, chloroplastic
- Septum site-determining protein minD homolog, chloroplastic
Sequence:
MATYVSPCFTPSDSRLLTVLRKNVLPENHLGRLNSIRTIDSKKNRVVVAAQKSESSPIRNSPRHYQSQAQDPFLNLHPEISMLRGEGTSTIVNPRKETSSGPVVEDFEEPSAPSNYNEARIKVIGVGGGGSNAVNRMIESEMSGVEFWIVNTDIQAMRMSPVLPDNRLQIGKELTRGLGAGGNPEIGMNAARESKEVIEEALYGSDMVFVTAGMGGGTGTGAAPVIAGIAKAMGILTVGIATTPFSFEGRRRTVQAQEGLASLRDNVDTLIVIPNDKLLTAVSQSTPVTEAFNLADDILRQGVRGISDIITIPGLVNVDFADVRAIMANAGSSLMGIGTATGKSRARDAALNAIQSPLLDIGIERATGIVWNITGGSDLTLFEVNAAAEVIYDLVDPTANLIFGAVVDPALSGQVSITLIATGFKRQEEGEGRTVQMVQADAASVGATRRPSSSFRESGSVEIPEFLKKKGSSRYPRV
Protein: Parp6 protein (B2RZ49)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILYMFTSQQWKHLSNDLLKTQQEKRHSWFKASGSIRKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRVPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFQ
Protein: Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)] (P22273)
Organism: Rattus norvegicus (Rat)
Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Subcellular location: [Interleukin-6 receptor subunit alpha]: Cell membrane {ECO:0000250|UniProtKB:P22272}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Soluble interleukin-6 receptor subunit alpha]: Secreted {ECO:0000250|UniProtKB:P22272}.
Interaction partners:
- Interleukin-6
- Interleukin-6 receptor subunit beta
- Interleukin-1 beta
- Interleukin-11
- Tumor necrosis factor
- Signal transducer and activator of transcription 3
- Tyrosine-protein kinase
- Suppressor of cytokine signaling 3
- Ciliary neurotrophic factor
- Tyrosine-protein kinase
Sequence:
MLAVGCTLLVALLAAPAVALVLGSCRALEVANGTVTSLPGATVTLICPGKEAAGNATIHWVYSGSQSREWTTTGNTLVLRAVQVNDTGHYLCFLDDHLVGTVPLLVDVPPEEPKLSCFRKNPLVNAFCEWHPSSTPSPTTKAVMFAKKINTTNGKSDFQVPCQYSQQLKSFSCEVEILEGDKVYHIVSLCVANSVGSRSSHNVVFQSLKMVQPDPPANLVVSAIPGXPRWLKVSWQDPESWDPSYYLLQFELRYRPVWSKXFTVWPLQVAQHQCVIHDALRGVKHVVQVRGKEEFDIGQWSKWSPEVTGTPWLAEPRTTPAGIPGNPTQVSVEDYDNHEDQYGSSTEATSVLAPVQGSSPIPLPTFLVAGGSLAFGLLLCVFIILRLKKKWKSQAEKESKTTSPPPYPLGPLKPTFLLVPLLTPSGSHNSSGTDNTGSHSCLGVRDPQCPNDNSNRDYLFPR
Protein: Inner membrane transport protein YdhC (P37597)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- HTH-type transcriptional regulator PunR
Sequence:
MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVIGLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHSESH
Protein: Forkhead box C1-A (Q9DE25)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine-induced endothelial cell migration. Plays a role in epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q61572}.
Interaction partners:
Sequence:
MQARYSVSSPNSLGVVPYISSDQSYYRAAAGGGYTGMPAPMTMYSHAAHDQYPASMARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNSPDKKVTLNGIYQFIMERFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAMKDKEDRGVKEAPSRQAQPQAREQEQSVPGSQPVRIQDIKTENGTSTPPQAVSPTLSTVPKIESPDSSSSMSSGSPHSIPSTRSLSLDSAGEQHHQAPAQGFSVDNIMTSLRGSPHSSGELTPSLVAPSRTGITPTLSLNYSPNQSSVYSSPCSQNSISTTSNATYHCNMQAMSLYAGGDRSGHLGTTATTVDETLPDYSITTTTSSLSHGNLSSAQEGHHPHQGRLASWYLNQAGDIGHLGATYPAQQQNFHSVREMFESQRIGLNNSPVNGNNSCQMSFPPSQPIYRTSGAFVYDCSKF
Protein: Protein Wnt (A1DYI3)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
- Low-density lipoprotein receptor-related protein
- Porcupine O-acyltransferase.
- Wnt inhibitory factor 1
- Notum, palmitoleoyl-protein carboxylesterase.
- Cerberus
- Protein wntless homolog
- Receptor like tyrosine kinase.
- Secreted frizzled-related protein 1
- Frizzled-1
- Frizzled-4
Sequence:
MDYHLLGLILSFLFNGTKVLAGYPIWWSLALGQQYSSLGSQPILCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNRHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDYLKDKYDSASEMVVEKHRESRGWVETLRAKYALFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRVYDVHTCK
Protein: Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) (O15409)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Contactin-associated protein-like 2
- Forkhead box protein P4
- C-terminal-binding protein 1
- Nuclear factor of activated T-cells, cytoplasmic 2
- Forkhead box protein P1
- Forkhead box P1
- T-box brain protein 1
- Forkhead box protein P3
- Roundabout homolog 1
Sequence:
MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSSVLSARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE
Protein: WD repeat and FYVE domain-containing protein 2 (Q18964)
Organism: Caenorhabditis elegans
Function: Plays a role in coelomocyte endocytosis.
Interaction partners:
- AP complex subunit sigma
- WD repeat and FYVE domain-containing protein 3
- PX domain-containing protein
- PX domain-containing protein
- ANK_REP_REGION domain-containing protein
- FYVE, RhoGEF and PH domain-containing protein tag-77
- FYVE-type domain-containing protein
- FYVE-type domain-containing protein
- Phospholipase
Sequence:
MAAIINQRVEQGESSMGGAKPALLHRITGHVARINDVILLSKDEGVWTASDDRSVRLYLKRDNDQFWPSIHHFMPVAPTSLYYSEETYKLLVGLINGNVYEFSVADDFNSMTESRKWTCHAGPISGLGFALSSELIFSCSRDKSIVWHCSENSNKMGSYLLENSCTAMVIDLPFVFVGDHGGHVTVLRIVDNQPNLVSKLSAHTNAITSLTWDGNKKVLYSGSSDHLIIMWDIGGGRGEAYELNGHNGKVTTLCAAPAAKRLFSADEHGKLMCWDMNCKRVETPEWKTSDCCQKCNQPFFWNLQAMWQRKVVGLRQHHCRTCGSAVCGSCCDNWTTYPPMGYETKIRICNDCNARMKDNPQNFNLTPLAIPHEIHTGITAMHLQETLGLLVTSGQNRVIMIWDVRSVCSAPSGSQ
Protein: Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1) (O08580)
Organism: Mus musculus (Mouse)
Function: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P11474, ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250|UniProtKB:P11474}. Note=Co-localizes to the cytoplasm only in presence of MAPK15. {ECO:0000250|UniProtKB:P11474}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Peroxisome proliferator-activated receptor gamma coactivator 1-beta
- PGC-1 and ERR-induced regulator in muscle protein 1
- Peroxisome proliferator-activated receptor gamma
- Nuclear receptor corepressor 1
- Steroid hormone receptor ERR2
- High affinity cationic amino acid transporter 1
- NAD-dependent protein deacetylase sirtuin-1
- Transcription factor A, mitochondrial
- Estrogen-related receptor gamma
Sequence:
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLASGPAPARCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
Protein: U3 small nucleolar RNA-associated protein 17 (U3 snoRNA-associated protein 17) (U3 protein 17 required for transcription) (O13878)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Nucleolar protein 58
- U3 small nucleolar RNA-associated protein 6
- U3 small nucleolar RNA-associated protein 4
- Probable U3 small nucleolar RNA-associated protein 7
- U3 small nucleolar RNA-associated protein 5
- Periodic tryptophan protein 2 homolog
- U3 small nucleolar RNA-associated protein 21 homolog
- U3 small nucleolar RNA-associated protein 15
- U3 small nucleolar RNA-associated protein 20
- U3 small nucleolar RNA-associated protein 22
Sequence:
MEGPNSMEVGSLEVKKNDKDPWSKTAYLGGRLVSKIPAVYSNDNKFVFLTYDTFIGIFSLITGDCINRIFFPNNLANLLPVAVLLSPENAFELYVIFQSGYVCVHDWSNSELLRTMEISTRVHAASFSGKLLFAVTDTPASDSASSQDRFTLYALSPSTSKEGSSILIPTFVSKFNEFLALDSSLRDNNLATVAVITTDKAIFSLNVPKKKRSQRWIHREHLFNMPQKLTNVSLCGSACAVSDDEGKIHVINDISNEKFNPQILHWHANPLNGLSWALNGEYLLSGGQEGVLVLWQMETSHRQFLPRLGSSILSIATSHDSDSYALHLGDNSLVVIRAVDLAEQIHVSGINSFESKYLTSTGPKNTSKQLQGLVQFSSVSPNGELLLMSSSSFNGHSVSVQEYDLTKDSTIRKFEAARYSYSSVSKNSDDATSLDNGHVGSVAVTSSRNGLYIATIDTWCTNIIDEQQRNVKQTALKFWQFDSVQKTWVLMTRIDNPHGNLEVVTALKMMTSSNRFITVGTDATLRIWALLPGSSAWKCVAIHHFANTHSQASIKQRYGFSKALTCSLDDSIIGFGYGSCMHFINSETLEEISTVDLPHGGQLENAQFLNAEHCVIISQRRLLVWNVISASVQWTLASKFTGLLASSSSGNDFAVIDFNSSYSRLIIFSPDSPKIQSIHIFKTLPVALHYLHGGFVVLDNKSIIHVYAGDLTTKIPSAQLSIDNTSRSLLGDFQKRNVPLLNLENPISGSQGLHYKRLTTDMIHNLFNVPSNSPVNMQAIYNTFSKMAVGEPMESLGTQIATLNTE
Protein: Exostosin-2 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (HS-polymerase) (HS-POL) (O77783)
Organism: Bos taurus (Bovine)
Function: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q93063}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q93063}; Single-pass type II membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q93063}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:9756849}. Note=The active heparan sulfate polymerase complex composed of EXT1 and EXT2 is localized in the Golgi apparatus though both proteins are also detected in the endoplasmic reticulum (By similarity). A soluble form is found in the serum (PubMed:9756849). {ECO:0000250|UniProtKB:Q93063, ECO:0000269|PubMed:9756849}.
Interaction partners:
- Exostosin-1
- 1-aminocyclopropane-1-carboxylate synthase-like protein 1
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
- Adenosine 3'-phospho 5'-phosphosulfate transporter 1
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
- 1-aminocyclopropane-1-carboxylate synthase homolog
- Exostosin-like 1
- Heparan sulfate 2-O-sulfotransferase 1
- Xylosyltransferase 2
- Beta-1,4-galactosyltransferase
Sequence:
MCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSGDWSVEKRTGRDVPLVRLPADSPVPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYPLKKYVGEAGVPVSSTISREYNELLTAISDSDYYTDDVTRACLFVPSIDLLNQNSLRVKETAQALAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRRYFLLSSQVALHPEYREDLAALQARHGEAVLVLDKCSNLSEGVPAARRRCHQQQAFDYPQVLQEATFCMVLRGARLGQAVLSDVLRAGCVPVIIADSYVLPFSEVLDWKRASVVVPEEKMSDVYSILQSIPRRQIEEMQRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEDWNDPPAVKWGSVSNPLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL