wanglab/gogpt-training-data huggingface dataset:
Protein: Glutamate receptor ionotropic, kainate 1 (GluK1) (Glutamate receptor 5) (GluR-5) (GluR5) (Q60934)
Organism: Mus musculus (Mouse)
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P22756}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P22756}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glutamate receptor ionotropic, kainate 2
- Glutamate receptor ionotropic, kainate 4
- Glutamate receptor ionotropic, kainate 5
- Glutamate receptor ionotropic, kainate 3
- Disks large homolog 4
- Glutamate receptor 2
- Noelin
- Lysine--tRNA ligase
- Voltage-dependent calcium channel gamma-2 subunit
- Glutamate receptor ionotropic, NMDA 2C
Sequence:
MERGTVLIQPGLWTRDTSWTLLYFLCYILPQTSPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGVMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQPSALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRLRFYFRNKVRFHGSKTESLGVEKCLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCHQRRTQRKETVA
Protein: Sorting nexin-31 (Q6P8Y7)
Organism: Mus musculus (Mouse)
Function: May be involved in protein trafficking.
Interaction partners:
- Winged helix repair factor 1
Sequence:
MKMHFCIPVSQQRPDALGGRYVLYSVYLDGFLFCKVRYSQLHRWDEQLRRVFGNCLPPFPPKYYLAMTTAMAEERRDQLERYLQNVTADPRVTRSDVFTEFLTLVQLHTLNITIQNVELAVFLPDGRSIKVEGLTSDTAERVLEVMAHKLGLQPDLVGYFGLFLIQCFPEGKLSVVKKLADFELPYTSLQSSEMENCKIGLRKWYLDPALDSMLMDCRAAGDLLYMQAVQDIEKEWMKPTQAQREELKALQKKENQTKFLELSQEVRHYGYVQLDPCTCNHPEPGCGAQLSIGNNEISCCITLPNGQIQDIAFQMSRVKCWQVTFLGTLLDTDGPQRTLNQNLELRFQYSEDSCQQWFVIYTKQAFFLSSCLKKMISERMTKLTEQSPEMQIEVPEQGRSKKHPSQPSQQKVYFNFLRKGKMKRSEGDYVWDTLMEEGL
Protein: Casein kinase 1-like protein 1 (EC 2.7.11.1) (Casein kinase 1) (Casein kinase I isoform delta-like) (CKI-delta) (Protein CASEIN KINASE I-LIKE 1) (P42158)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P48730}. Cell junction, plasmodesma {ECO:0000269|PubMed:16126836}. Note=Present in punctate particles with granular structure. {ECO:0000269|PubMed:16126836}.
Interaction partners:
- Cryptochrome-2
- At3g49990
- Cryptochrome-1
- Cytochrome P450, family 705, subfamily A, polypeptide 25
- Peroxidase 13
- Shaggy-related protein kinase delta
- Serine/threonine-protein kinase MPS1
- Protein WVD2-like 2
- Cyclin-dependent kinase B1-2
- Cyclin-dependent kinase B1-1
Sequence:
MEPRVGNKFRLGRKIGSGSFGEIYLGTNIHTNEELAIKLENVKTKHPQLLYESKLYRILQGGTGVPNVKWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKSVLMLADQMINRVEFFHSKSFLHRDLKPDNFLMGLGRRANQVYIIDFGLAKKYRDSTTHQHIPYRENKNLTGTARYASMNTHLGIEQSRRDDLESLGYILMYFLKGSLPWQGLKAGTKKQKYERISEKKVSTSIEALCRGYPSEFASYFHYCRSLRFDDKPDYAYLKRIFRDLFIREGFQFDYVFDWTILKYQQSQLTAPPSRALNPAVGTSAALPPGISNIDRYTGEEEGRPHMESSRRRVSGALDNSGNISNQPTSSSARDSMIPSSSLFAQSAGSSRRVTAVSGSRDNFPGSEELLQRSRTGDVSRGVIPRNSPGEAGKSTRRHYESVVKGIDNLQVSDEHHPH
Protein: Large ribosomal subunit protein eL19y (60S ribosomal protein L19-3) (P49693)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein uS2z
- Large ribosomal subunit protein uL3z
- Large ribosomal subunit protein uL24y
- Large ribosomal subunit protein uL24z
- Small ribosomal subunit protein uS2y
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein uL23y
Sequence:
MVSLKLQKRLASSVLKCGKRKVWLDPNEGSDISMANSRQNIRKLVKDGFIIRKPTKIHSRSRARQLNIAKRKGRHSGYGKRKGTREARLPTKVLWMRRMRVLRRLLKKYRETKKIDRHMYHDMYMKVKGNVFKNKRVLMESIHKSKAEKAREKTLSDQFEAKRAKNKASRERKHARREERLAKGPGGDIPAAAPPAQTAEVPAKKSKK
Protein: Liprin-alpha, isoform E (M9PCD4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Rab3 interacting molecule, isoform F
- Unc-13, isoform E
- Tyrosine-protein phosphatase Lar
- AT31531p
- RIM-binding protein, isoform F
- Ras-related protein Rab-3
- Bruchpilot, isoform J
- Peripheral plasma membrane protein CASK
- ARF GTPase-activating protein Git
- Neurexin 1, isoform F
Sequence:
MWNMMCDVMPTISEDSISQRSSQFSGEDANFEQLMVSMLDERDKLMDSLREAQERLNETENKLRDVEKERDSLQRQINANLPQEFATLTKELTQARETLLERDEEIGELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAAAQSGVSSEVEVLKALKSLFEHHKALDEKVRERLRLSIEKNNMMEEELSSAKEELAQYKAGVVPAGVGSGSGAGSAATTAGGGGAENGLKEKMAGVGGSGGVNGEANELNDYAAKTHELQTIIEKQTSELSQWQRRVSDLNNKISELEENMSRVQKEHCKAQDQCAKLQRDLRENVAQKEDQEERITTLEKRYLNAQRESTSLHDLNEKLEQELRHKEAQLKLHEEKIGAIEEKLELSEQKLAQHAKLQPDMEEQLKARMEALTKAQERHGSAEDRIRGLETNLDEKTNEVVRLNQRLKMNEEHNLRLSSTVDKLLSESNERLQVHLKERMHALDEKNALTQELEKARKVAEELHHEKSEIMKELSKTRLEIENFKRQLLQQEIAYNIQQTEALTRSLSPSSVVDPSGAFSRSNSHASFETHSLRRQSKQRLSEENALVRSMAEQEWEKLQQAAHAQQQAYELASAADCDDSDVLYAAATDMMSPSGHTDAQTLAMMLQEQLDAINNEIRLIQEEKQSTEARAEELESRVGSLEHVNLLARGRSMDRQSPPMSGRSTPNSPQRDFMQKYHTLNLPVLSSDASREELHGGMSTTGDSSSGGAASPLTARSMRLERVAQALAHSQEELRRRSIGLNPNASVAPNHTGGHMPLSSHSYGLSPLSSRYGSQESLRHYNTMGSMSMLQTPTSGVSREAAAAAVQKKKGIKSSLGRFFSKKEKVKGVKDTLPDGSPSMMSIGNLSIGLSEVDSNYDAMSMTGGMMPRIASSQGSKISSVDYGRQKKEHDYRNDLLGEAMKAGTPFALWNGPTIVAWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPQTSRTTLAFGDMNHEWIGNYWLPGLGLPQYRTTFMECLVDARMLDHLTKKDLRGQLKMVDSFHRTSLQYGISMLKRLNYDRTELEHRRKMSENGLCDVLVWSNERVIRWVGSIGLKEYANNLLESGVHGGLMALDEGFDANAMGLALQIPTQNAQARQILDTEFNNLLQIATDRRPENEQRSASXCSYSPPTSSVDE
Protein: RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (F1QLR3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q61584}. Cytoplasm {ECO:0000250|UniProtKB:Q61584}. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments. {ECO:0000250|UniProtKB:Q61584}.
Interaction partners:
Sequence:
MEELTVEVRGSNGAYYKGFVRDVHDDSLSISFENNWQPERQVPFSDVRLPPSADTKKEIGEGEEVEIFSRANEQEPCGWWLAKVRMMKGDFYVIEYAACDATYNEIVTFERLRPVNRNKAVTESTFFRCSVPVPEDLRAACESEQAHKEFKKAVGAIRIVYSPEKSELVVLSLSEATVKRVSLLSDIHLRSIRTKLMLMSRNQEATKHLESTKQLASAFQEEFTVREDLMGLAIGSHGSNIQQARKVPGVTAIELEEETGTFRIYGESTEAVQKARNYLEFLEDSVQIPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNDNKLPRQEGMVPFTFVGTKESISNVQVLLEYHIAYLNEVEQLRLERLQIDEQLRQIGMGFRSVPNRPADKEKGFGPDESSSGSIHTQRSYRGRGRRGPAHTSAYGTNSEHSYTSETDSERKAELSDWSLAADESERNPRPQRDSRRRDLRGRGRGSRGRGASNSISSVLKDPDGNPYSLLDNTETDQTADTDGSESQMNTSRRRRSRRRRTDEDTTVMDGMSESDNASLSENGLVTVADYISRAESQSRQTNPRDTRKSKKDMTRGDFISEHSAAESVSNGPNNADEPSESAKAVVNGVS
Protein: Uncharacterized protein C962.01 (O14065)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein C691.05c
- Uncharacterized protein C23C11.01
- Vesicle-associated membrane protein-associated protein scs2
- Vesicle-associated membrane protein-associated protein scs22
- Oxysterol-binding protein homolog C23B6.01c
- ATP synthase subunit 9, mitochondrial
- Oxysterol-binding protein homolog C2F12.05c
Sequence:
MEGENSKSVHPILSHSTSVVSERASSSGVNGTNGGMKQVSPVSTARTSIARRPPSTVGSQTGSLVNAPPKRSSGIERFDHVTGTAENRPQTPSTKASVANVKPAGAAESAQNANLISSKSENVPEPAGEKVSMPEKQDLQSALPSDAVSNAVIGWKSIYHASDVDVHDHFANVLSALQWDSHRVEPSILETYSSYKLTGQWWQSTSILLAVSILSWIASKLWFRFFILFFIIITGTIVYGSCMISVRRNIREEVVQELSKKNGDVDYETMSWFNTLLQRFWMLNEPEISKSVSTSVEQSIAEYLPSFIKEAAFSTFTLGSKAPRIDRVRTHPPVERDVVLMDVDFSLTPNDNYDVNDSSLKCRVNSLISLVIKFGFGKYMFSFPITIKDLRLSGKLRIRWGLSSDYPFIQTASFSFLETPIVYANIRPIDIPFLDADIFYIPGIGQFVSEQLGLLLNSMVLWPNMFDYDLSAMMAGIASGTAVGVVGLKIYSARRGEVSDSSIDRKPSSFITVTTSGREHGRTPIRSNTFSPTFDTTIYVVINSLNDPLKLSLYDNSGKSPILVGTTYIDPRSLYERGFIGDIYQFLYNAVNVGSVAFDATFFPSLLPKKTMDGSKIEPPESSKGILNVNLGCVNNLTELTELTKKSSLKYVLYVDSKEVASKTIKFVDRTPISLQTNAYIENNKKSSIKVAVFDVKSPEKAIATVSVPLPELLHEGYDTFHFVENPKATIDIESFWTPVDVVEEKSAKTYIDNLVGVMRLSVIKANDLVNVELPTRKSDPYARVIVGNSVVARTVYTPNNLNPIWNEILYVPIMADTKTIDLEAMDYEESGNDRSLGYASINVQKYIRNAKRLDRSALASTVFGTSEVNALTLTSRKGQSVRGTISVNCDYRPCLRLNTDNSSKQSSENVQSATDPTTPAKDNSTSNAETSSITSVISVNEALQYPSGFALISIVSADLQDVGVDLRVFTDNAAFPFITTPIAKTKTPRWSSFGISMVRELQFSETTFQLTDGAKKDPKVVCEHSVKTLDLVSEALGRPYSVEIPGSNGQLNHVRLSITYMPVPMTLNPMESYINSGSLHFMLQDGQNLPIGDIRSSDPFVVLKLNGESAFKSKVIKKNLNPVWNEEADIVVQNRVLDVLELVCYDWDMGEKPDVLGTSNIDLLSLEPNVESQQSIKLDSKTGTINASLRFVPGWHRRKAVLDVTLADNFLHAANKGAKLVVGGVGAAGGLALAGVTTIGSVGSKAVTGVADGVTGTGKHIISGAKGISKMGMFRRSLEKNPSRSDLTTTQEASSSASVPPAIAPESANAALTSTIDKTTGAPELAQKKYKVYVGQGKNMPHKTIKIIVTDNQDHSFKTKSRKGPSPSWNEEIPVKWSLGDELRISAVTSNLLGHTKLGEAVFQEDAIGTFRVVIGGSSSVEIKVEAE
Protein: Ion transport protein (Q0ABW0)
Organism: Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSERQPDLVGHKVQHPEDETLRGRLAWFIDRPGTQYFIVGLILVNAITLGLMTSPEVTAYLQPWLGWVNTFIIAAFVVEISLRIIADGPRFVRSGWNLFDFSVVAISLVPDSGAFSVLRALRILKVLRLFSMVPRLRRIVEALLRAIPGIAWIALLLLVIFYVFAVMGTKLFAQSFPEWFGTLGASMYTLFQVMTLESWSMGIARPVIEAYPWAWIYFVSFILVSSFTVLNLFIGIIIESMQSAHWEAEDAKRIEQEQRAHDERLEMLQLIRDLSSKVDRLERRSGKR
Protein: Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein) (O95865)
Organism: Homo sapiens (Human)
Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21898353, ECO:0000269|PubMed:33850055}. Mitochondrion {ECO:0000269|PubMed:21898353, ECO:0000269|PubMed:33850055}. Note=Translocates from cytosol to mitochondrion upon IL1B stimulation in chondrocytes.; SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:33850055}. Note=(Microbial infection) Translocates to the mitochondrion upon Sendai viral infection. {ECO:0000269|PubMed:33850055}.
Interaction partners:
- Alanine--glyoxylate aminotransferase 2, mitochondrial
- Nitric oxide synthase 3
- Protein arginine N-methyltransferase 1
- Band 4.1-like protein 2
- Secretagogin
Sequence:
MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGGPRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGLPGVPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHS
Protein: POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3.1) (Brain-3.1) (zfBrn-3.1) (Q90435)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q15319}. Cytoplasm {ECO:0000250|UniProtKB:Q15319}. Note=Preferentially localized in the nucleus. {ECO:0000250|UniProtKB:Q15319}.
Interaction partners:
- Atonal bHLH transcription factor 1a
- Growth-associated protein 43.
- Myosin VIIAa
- Insulin gene enhancer protein isl-2b
- Myosin VIb
- Paired box protein Pax-2a
- Growth factor-independent 1A transcription repressor b.
- Claudin b
Sequence:
MMTMNGKQHFSMHPALHPSSEGMRRVCLPAPQLQGNIFSGFDESLLARAEALAAADIVSHGKSHPFKTDVTYHTMSSVPCTSSSSTVPISHPSSNLPSHHHHHLSHQTLEGDLLDHISSSLSVSGMGAPPDPSVMTTQAHQHHLQMGHLHQAMAMGHPHTLSVHNGMACVNDVESDPRELEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNGKPDLFNGNERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
Protein: S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (Methionine adenosyltransferase) (MAT) (P40320)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Interaction partners:
- S-adenosylmethionine decarboxylase proenzyme
- Betaine-homocysteine S-methyltransferase
- FI01821p
- Tyrosine aminotransferase
- GH04035p
- Serine hydroxymethyltransferase
- Adenosylhomocysteinase-like 1
- Adenosylhomocysteinase
- Adenosylhomocysteinase-like 2
- Acireductone dioxygenase-requiring))
Sequence:
MPQKTNGHSANGCNGSNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLEIDN
Protein: E3 ubiquitin-protein ligase (EC 2.3.2.26) (A0A590UK44)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
Protein: DELLA protein RGL2 (GRAS family protein 15) (AtGRAS-15) (RGA-like protein 2) (Scarecrow-like protein 19) (AtSCL19) (Q8GXW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. No effect of the BOI proteins on its stability. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes. Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway. Acts as a major GA-response repressor of seed germination, including seed thermoinhibition. Promotes the biosynthesis of abscisic acid (ABA), especially in seed coats to maintain seed dormancy. Delays flowering and adult leaf production. Also regulates the floral development, petal, stamen and anther development, by repressing the continued growth of floral organs. Its activity is probably regulated by other phytohormones such as auxin and ethylene. Involved in the regulation of seed dormancy and germination, including glucose-induced delay of seed germination. Promotes salt tolerance. Acts as a repressor of positive regulators of trichome initiation. Required during the flagellin-derived peptide flg22-mediated growth inhibition. Contributes to the susceptibility to the biotrophic pathogen P.syringae pv. tomato and to the resistance to the necrotrophic pathogens B.cinerea A.brassicicola, probably by repressing the SA-defense pathway and preventing cell death. Prevents stress-induced reactive oxygen species (ROS) accumulation (e.g. salt stress) by acting on the ROS scavenging system, and delays ROS-induced cell death, thus promoting stress tolerance.
Subcellular location: Nucleus {ECO:0000269|PubMed:20093430}.
Interaction partners:
- Gibberellin receptor GID1A
- Transcription factor PIF3
- Gibberellin receptor GID1B
- Gibberellin receptor GID1C
- F-box protein GID2
- Transcription factor PIF4
- Transcription factor PIF5
- Transcription factor MYC2
- Nuclear transcription factor Y subunit C-3
- Gibberellin 3-beta-dioxygenase 1
Sequence:
MKRGYGETWDPPPKPLPASRSGEGPSMADKKKADDDNNNSNMDDELLAVLGYKVRSSEMAEVAQKLEQLEMVLSNDDVGSTVLNDSVHYNPSDLSNWVESMLSELNNPASSDLDTTRSCVDRSEYDLRAIPGLSAFPKEEEVFDEEASSKRIRLGSWCESSDESTRSVVLVDSQETGVRLVHALVACAEAIHQENLNLADALVKRVGTLAGSQAGAMGKVATYFAQALARRIYRDYTAETDVCAAVNPSFEEVLEMHFYESCPYLKFAHFTANQAILEAVTTARRVHVIDLGLNQGMQWPALMQALALRPGGPPSFRLTGIGPPQTENSDSLQQLGWKLAQFAQNMGVEFEFKGLAAESLSDLEPEMFETRPESETLVVNSVFELHRLLARSGSIEKLLNTVKAIKPSIVTVVEQEANHNGIVFLDRFNEALHYYSSLFDSLEDSYSLPSQDRVMSEVYLGRQILNVVAAEGSDRVERHETAAQWRIRMKSAGFDPIHLGSSAFKQASMLLSLYATGDGYRVEENDGCLMIGWQTRPLITTSAWKLA
Protein: Protein nutcracker (Q8SX86)
Organism: Drosophila melanogaster (Fruit fly)
Function: Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20392747, ECO:0000269|PubMed:21529711}. Note=In the spermatid, colocalizes with Cul1 at the actin-based individualization complex and the cystic bulge. {ECO:0000269|PubMed:20392747, ECO:0000269|PubMed:21529711}.
Interaction partners:
- Proteasome inhibitor PI31 subunit
- Cullin homolog 1
- Cullin 6
- GEO01111p1
- Cullin 3, isoform F
- RING-box protein 1B
- S-phase kinase-associated protein 2
- Cyclin-G-associated kinase
- Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
- Mitochondrial ribosomal protein L2
Sequence:
MSDTKSEIEGFIAIPTTSGEQQQQQPQQQQNEQQVVGTKDIKAPDQVGKKQRPRLIQEKSTQETNPLILEHATLEWVPQHMDKLLNQYQECRKMPAAEWLHLLTYLVALECGFVEEETFAQKRHLIQPVPSFSSFHAQNVRILSEQPARYEVCFNDTVYIMRLRTLLDKHAPEETSLVAALQCRLMAVSLGDQLMITLSPAPPSKEPGYSVSLSIGRYVLNIQAKNKPIYHRFRKLDELSYQLKQHLFQPMRSQQLMQMEMKLQPSLLGLPDELYFEIFRYLDKSQLNVVARVNRHLHFYSKEVERKRLKGGRS
Protein: Neurexin-1-beta (Neurexin I-beta) (Q63373)
Organism: Rattus norvegicus (Rat)
Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).
Subcellular location: Presynaptic cell membrane {ECO:0000269|PubMed:17868325}; Single-pass type I membrane protein {ECO:0000269|PubMed:17868325}.
Interaction partners:
Sequence:
MYQRMLRCGAELGSPGGGSSGGAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHSVPIAIYRSPASLRGGHAGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYV
Protein: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) (Q3THK7)
Organism: Mus musculus (Mouse)
Function: Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49915}.
Interaction partners:
- Adenine phosphoribosyltransferase
- Inosine-5'-monophosphate dehydrogenase 1
- Inosine-5'-monophosphate dehydrogenase 2
- Ubiquitin carboxyl-terminal hydrolase 7
- GMP reductase 1
- Hypoxanthine-guanine phosphoribosyltransferase
- GMP reductase 2
- Inosine triphosphate pyrophosphatase
- Guanylate kinase
- CTP synthase 1
Sequence:
MALCNGDSKPENAGGDLKDGSHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPILGICYGMQMMNKVFGGTVHKKSVREDGVFNISMDNTCSLFRGLQKEEIVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGVQFHPEVGLTENGKVILKNFLYDIAGCSGNFTVQNRELECIREIKEKVGTSKVLVLLSGGVDSTVCTALLNRALNQDQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMSLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELDLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNINRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGFAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGVPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE
Protein: Outer spore wall protein 7 (P43611)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in spore wall assembly.
Interaction partners:
- Putative uncharacterized protein YJR037W
- Outer spore wall protein 6
- Outer spore wall protein LDS2
- Ectonucleotide pyrophosphatase/phosphodiesterase 2
- Outer spore wall protein 4
- Ectonucleotide pyrophosphatase/phosphodiesterase 1
- Outer spore wall protein 2
Sequence:
MKAVFKVTTALLACVFIARYLVCQQNGLGSFATDLQPICRHTEFSVGSLFDSKLVEGSAVSDYLVGKYSQSIKPLIERYPNSSLKRIMGYFYRFWYNIFSFLRLNELCCSLHSKLGPLLNHLRIAWYYLKPYTDNVKNVLENPFNSSTDWMKYGSFSADGTLTKPIFETDSETEDYEDDENENEDEDEDEDEDDVGIEDENKEYEFDGVQDGHGNSQLVTAAILQDLSKIIIGSNSHAELETYEAESLKMEYEAWIKAIDSKIHSAMALLDSEIQSVFEAEVQNKSIEITRNLDDLNTTVNEQLVFLDSKIKDINCTSKFDPVQNKIKYFDESGQVELEAYITKSSITSILKNYKIHLLDFEKSLFHSLDSFLTEMAKLAESIRLENVEVYEEWGDVMISQWSQRMAYMDVRGLHLEDQYDPAYIEENHSNWLRFMELKKKVISERNRLVKHDLDMTLILEWITKLKADFQNTKNNIQDTFLQRMNTADTLFKNRELKEQLEEEFVRQEH
Protein: Acid stress chaperone HdeA (10K-S protein) (P0AES9)
Organism: Escherichia coli (strain K12)
Function: Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA.
Subcellular location: Periplasm {ECO:0000255|HAMAP-Rule:MF_00946, ECO:0000269|PubMed:17085547}.
Interaction partners:
- Glutamate decarboxylase beta
- Acid stress chaperone HdeB
- Protein HdeD
- Glutamate/gamma-aminobutyrate antiporter
- Glutamate decarboxylase alpha
- Transcriptional regulator GadE
- Outer membrane protein Slp
- Putative magnesium transporter YhiD
- HTH-type transcriptional regulator GadX
- HTH-type transcriptional regulator GadW
Sequence:
MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLAVDESFQPTAVGFAEALNNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGEWDKIKKDM