wanglab/gogpt-training-data huggingface dataset:
Protein: Protein sax-3 (Sensory axon guidance 3) (G5EBF1)
Organism: Caenorhabditis elegans
Function: Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Slit homolog 1 protein
- UNC-34
- Netrin unc-6
- NCK adaptor protein family
- Ephrin receptor 1
- Protein eva-1
- Netrin receptor unc-40
- CRAL-TRIO domain-containing protein
- Kinesin-like protein vab-8
- SWIM-type domain-containing protein
Sequence:
MFNRKTLLCTILLVLQAVIRSFCEDASNLAPVIIEHPIDVVVSRGSPATLNCGAKPSTAKITWYKDGQPVITNKEQVNSHRIVLDTGSLFLLKVNSGKNGKDSDAGAYYCVASNEHGEVKSNEGSLKLAMLREDFRVRPRTVQALGGEMAVLECSPPRGFPEPVVSWRKDDKELRIQDMPRYTLHSDGNLIIDPVDRSDSGTYQCVANNMVGERVSNPARLSVFEKPKFEQEPKDMTVDVGAAVLFDCRVTGDPQPQITWKRKNEPMPVTRAYIAKDNRGLRIERVQPSDEGEYVCYARNPAGTLEASAHLRVQAPPSFQTKPADQSVPAGGTATFECTLVGQPSPAYFWSKEGQQDLLFPSYVSADGRTKVSPTGTLTIEEVRQVDEGAYVCAGMNSAGSSLSKAALKVTTKAVTGNTPAKPPPTIEHGHQNQTLMVGSSAILPCQASGKPTPGISWLRDGLPIDITDSRISQHSTGSLHIADLKKPDTGVYTCIAKNEDGESTWSASLTVEDHTSNAQFVRMPDPSNFPSSPTQPIIVNVTDTEVELHWNAPSTSGAGPITGYIIQYYSPDLGQTWFNIPDYVASTEYRIKGLKPSHSYMFVIRAENEKGIGTPSVSSALVTTSKPAAQVALSDKNKMDMAIAEKRLTSEQLIKLEEVKTINSTAVRLFWKKRKLEELIDGYYIKWRGPPRTNDNQYVNVTSPSTENYVVSNLMPFTNYEFFVIPYHSGVHSIHGAPSNSMDVLTAEAPPSLPPEDVRIRMLNLTTLRISWKAPKADGINGILKGFQIVIVGQAPNNNRNITTNERAASVTLFHLVTGMTYKIRVAARSNGGVGVSHGTSEVIMNQDTLEKHLAAQQENESFLYGLINKSHVPVIVIVAILIIFVVIIIAYCYWRNSRNSDGKDRSFIKINDGSVHMASNNLWDVAQNPNQNPMYNTAGRMTMNNRNGQALYSLTPNAQDFFNNCDDYSGTMHRPGSEHHYHYAQLTGGPGNAMSTFYGNQYHDDPSPYATTTLVLSNQQPAWLNDKMLRAPAMPTNPVPPEPPARYADHTAGRRSRSSRASDGRGTLNGGLHHRTSGSQRSDSPPHTDVSYVQLHSSDGTGSSKERTGERRTPPNKTLMDFIPPPPSNPPPPGGHVYDDIFQTATRRQLNRGSTPREDTYDSVSDGAFARVDVNARPTSRNRNLGGRPLKGKRDDDSQRSSLMMDDDGGSSEADGENSEGDVPRGGVRKAVPRMGISASTLAHSCYGTNGTAQRFRSIPRNNGIVTQEQT
Protein: Protein FAM131C (Q96AQ9)
Organism: Homo sapiens (Human)
Interaction partners:
- Hippocalcin-like protein 4
Sequence:
MGSCVSRDLFTSAHKNCPMPQGADPLNPDLPSGRTPTVAPDCVIGKDKQMDFCWDPWQRCFQTTNGYLSDSRSRPGNYNVAALATSSLVGVVQSIKDHITKPTAMARGRVAHLIEWKGWSAQPAGWELSPAEDEHYCCLPDELREARFAAGVAEQFAITEATLSAWSSLDEEELHPENSPQGIVQLQDLESIYLQDSLPSGPSQDDSLQAFSSPSPSPDSCPSPEEPPSTAGIPQPPSPELQHRRRLPGAQGPEGGTHPPGSLPSMDSGSLWEEDEVFYN
Protein: Vacuolar protein sorting-associated protein 3 (Vacuolar protein-targeting protein 17) (P23643)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for sorting and processing of soluble vacuolar proteins, integrity of vacuolar morphology, efficient segregation of vacuolar material into the bud during the cell cycle, acidification of the vacuolar lumen, and assembly of the vacuolar H(+)-ATPase.
Subcellular location: Cytoplasm.
Interaction partners:
- Vacuolar protein sorting-associated protein 8
- Vacuolar protein sorting-associated protein 33
- Vacuolar protein sorting-associated protein 16
- Vacuolar morphogenesis protein 6
- E3 ubiquitin-protein ligase PEP5
- Vacuolar protein sorting-associated protein 41
- Vacuolar membrane protein PEP3
- Vacuolar protein sorting-associated protein 21
- GTP-binding protein YPT52
- Ypt/Rab-type GTPase YPT7
Sequence:
MVKKKTNNDKGKEVKENEGKLDIDSESSPHERENDKKKTEDDSLRATESEETNTHNANPNETVRADKFSQEESRPIEDSPHTDKNTAQESCQPSSAEDNVINTDITSLNEKTSTNDEQEKGLPLKISEGPFTISTLLDNVPSDLIYTCCEAYENHIFLGTTTGDLLHYFELERGNYMLVSQTKFDAESNSKIDKILLLPKVEGALILCDNELVLFILPEFAPRPNTTRLKGISDVVICNFSRSSKAYRIYAFHAEGVRLLKISADSLVLTKAFNFKLIDKACAHEETLMVSKLNSYELINLKSSQVIPLFRISETDEDLEPIITSFNEQSEFLVCSGGGSYDSGAMALVVNHHGDIIKGTIVLKNYPRNVIVEFPYIIAESAFQSVDIYSALPSEKSQLLQSITTSGSDLKISKSDNVFTNTNNSEEFKEKIFNKLRLEPLTHSDNKFRIERERAFVEESYEEKTSLIVYNNLGIHLLVPTPMVLRFTSCEESEIDNIEDQLKKLAKKDLTKFEHIEAKYLMSLLLFLMTLHYDHIEDEVMKKWCDFSDKVDIRILFYMFGWKVYSEIWCFHGLINIVERLKSLKLTNKCENILKMLLMMKNELKKKNKTGLLTNDFDDIMKTIDITLFKLRLEKKETITVDMFERESYDEIIREINLHDDKLPRIELLIEIYKEKGEYLKALNLLREAGDYISLVSFIEENLKKLPEDYIKERIADDLLLTLKQGDENTEECAIKKVLKILDMACINKNDFLNKIPAEETSLKVSFIEQLGVQNSNDSKFLFNYYLAKLREIINQSNIWSILGDFIKEYKDDFAYDKTDITNFIHIKLKHSLQCENFSKYYEKCENLKSENEKDDEFINFTFDEISKIDKEHILTLLFFPNELTNWVSSEELLKIYLSFNDFRSVEKYIGKQNLVAVMKQYLDISSLNYSVELVTNLLQRNFELLDDTDIQLKILETIPSVFPVQTISELLLKVLIKYQEKKEESNLRKCLLKNQISISDELSRNFDSQG
Protein: Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Lysophospholipid receptor B3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3) (Q9Z0U9)
Organism: Mus musculus (Mouse)
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Sphingosine kinase 2
- Sphingosine kinase 1
- Proheparin-binding EGF-like growth factor
- Sphingosine-1-phosphate transporter SPNS2
Sequence:
MATTHAQGHQPVLGNDTLREHYDYVGKLAGRLRDPPEGGTLITTILFLVTCSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGRKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKKHRVFLLIGMCWLIAFSLGALPILGWNCLENFPDCSTILPLYSKKYIAFLISIFTAILVTIVILYARIYCLVKSSSRRVANHNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRAKECSILFKSQWFIMLAVLNSAMNPVIYTLASKEMRRAFFRLVCGCLVKGKGTQASPMQPALDPSRSKSSSSNNSSHSPKVKEDLPRVATSSCIIDKNRSFQNGVLCK
Protein: Protein snail homolog Sna (Protein Xsnail) (Protein xSna) (P19382)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional repressor. Acts upstream of snai2/slug, zic5 and other neural crest markers in the specification of the neural crest and neural crest migration. Involved in embryonic mesoderm formation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MPRSFLVKKHFSASKKPNYSELESQTVYISPFIYDKFPVIPQPEILSTGAYYTPLVWDTGLLTTFFTSESDYKKSPISPSSSDDSSKPLDLTSFSSEDEGGKTSDPPSPASSATEAEKFQCNLCSKSYSTFAGLSKHKQLHCDSQTRKSFSCKYCEKEYVSLGALKMHIRSHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCTHCNRAFADRSNLRAHLQTHSDVKKYQCKSCSRTFSRMSLLHKHEETGCTVAH
Protein: Hexamethylene bisacetamide inducible, isoform B (Q8INF6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- La-related protein 7
- Cyclin-dependent kinase 9
- Cyclin-T
- 7SK snRNA methylphosphate capping enzyme bin3
Sequence:
MAEAVKNGKNRHSGSAEKESGSQQRPLDSGGGGGASGGGGVAVGGGSGMPKRKHRRGKKSKMQPKKTKNHYPQWKLDMSTGAGATLEGNQRQNSRTKLVRSRSLLVPYNTNRFLMEEHMSELHKDDSDDNCFGSQTEDQVLFLSKEFSDVYERARLERLETMSKQELIQECMQIEDRYSKAQNISKEFGAKLRAQDDKIRQLSRENQFLRTHLLRTCSATAGPAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQPTPMDSTSEDSESDSSSTTSSTTSTTSSTSSDGHEMGVAGLNIANGHAERHERSRTRSRSRSPIHLNGHANEEERQRLLDGNQMEEDDNSSDVSRPADAVVK
Protein: Ammonium transporter Rh type B (Rhesus blood group family type B glycoprotein) (Rh family type B glycoprotein) (Rh type B glycoprotein) (Q9H310)
Organism: Homo sapiens (Human)
Function: Functions as a specific ammonium transporter.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11024028, ECO:0000269|PubMed:15929723}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:15611082}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MAGSPSRAAGRRLQLPLLCLFLQGATAVLFAVFVRYNHKTDAALWHRSNHSNADNEFYFRYPSFQDVHAMVFVGFGFLMVFLQRYGFSSVGFTFLLAAFALQWSTLVQGFLHSFHGGHIHVGVESMINADFCAGAVLISFGAVLGKTGPTQLLLMALLEVVLFGINEFVLLHLLGVRDAGGSMTIHTFGAYFGLVLSRVLYRPQLEKSKHRQGSVYHSDLFAMIGTIFLWIFWPSFNAALTALGAGQHRTALNTYYSLAASTLGTFALSALVGEDGRLDMVHIQNAALAGGVVVGTSSEMMLTPFGALAAGFLAGTVSTLGYKFFTPILESKFKVQDTCGVHNLHGMPGVLGALLGVLVAGLATHEAYGDGLESVFPLIAEGQRSATSQAMHQLFGLFVTLMFASVGGGLGGLLLKLPFLDSPPDSQHYEDQVHWQVPGEHEDKAQRPLRVEEADTQA
Protein: PvdJ (Q9I181)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Pyoverdine synthetase D
- PvdL
- NADH-quinone oxidoreductase subunit C/D
- L-ornithine N
- Probable non-ribosomal peptide synthetase
- Pyoverdine biosynthesis protein PvdE
- MbtH-like domain-containing protein
- Probable non-ribosomal peptide synthetase
- phosphoribosylglycinamide formyltransferase 1
- Pyochelin synthetase PchE
Sequence:
MSFARLPIPQTRQEMDNLPLSYAQERQWFLWQLEPESSAYHIPTALRLRGRLDIASLQRSFAALVERHESLRTRIARMGDEWVQVVSADVSLALEVEVQRGLDEQRLLERVEAEIARPFDLEQGPLLRVTLLEVDADEHVLVMVQHHIVSDGWSMQLMVEELVQLYAAYSQGLDVVLPALPIQYADYALWQRSWMEAGEKERQLAYWTGLLGGEQPVIELPLDHPRQPLRSYRGAQLDLELEPHLALALKQLVQRKGVTMFMLLLASFQALLHRYSGQADIRVGVPIANRNRVETERLIGFFVNTQVLKADINGRMGFDELLAQARQRALEAQAHQDLPFEQLVEALQPERSLGHNPLFQVMFNHQADSRSANQGVQLPGLSLERMEWRSSSVAFDLTLDVHEAEDGIWASFGYATDLFEASTVERLARHWQNLLRGIVAEPGRPVAELPLLLDEERDCLSRAWAENADEGGLPPLVQLQIQEQARLRPQAQALALEGQALSYAELNARANRLAHCLIARGVGPDVLVGIAVERSLDMVVGLLAILKAGGAYVPLDPTYPQDRLRHMLEDSAVGLLLSQEHLLPGLPLHEGLEVLSIDRLERDASVSTDDPVVNLRPENLAYVIYTSGSTGKPKGVAISHAALAQFSRIASGYSALTPEDRILQFATLSFDGFVEQLYPALTRGACVVLRGGDLWDTGELYRQIVEQGVTLADLPTAYWNLFLLDALAEPRRSYGALRQIHIGGEAMPLEGPKLWRQAGMGRVRLLNTYGPTEATVVSSVFDCSAENARVGNASPIGQALPGRTLLVLDEHLGLLPVGPVGELYIASRAGLARAYHDRPGLTAERFLPDPFGEPGSRLYRTGDLARRRGDGVIEYMGRADHQVKIRGFRIELGEVEARLLDLEGIREAAALALDGQLVAYLVAEGGEDETRQPALRERIRTALRASLPDYMVPSHLLFLERMPLSPNGKLDRRALPKPDAGLMQRDHMAPASALEKDVAAIWGELLGVERVGLTDNFFELGGHSLLATRLVSRIRQDLGIEVSLKSLFEQPVLQGFVESLGEKPAEVPPITPVTREQPLPLSYAQERQWFLWQLEPESAAYHIPAALRLRGGLDVVALQRSFERLAQRHESLRTRFRQEGLRTVQVVDADGQLQVSRHNLANVDDASLRAAVEAEMARPFDLRTDALLRISLFEVAPNDHVLVMVQHHIVSDGWSMQLMVEELVQLYAAYSQGREAALPALPIQYPDYAVWQREWMEAGERERQLAYWIGLLGGEQPVLELPFDRPRPAEQSFRGARLEFELGAERARRLKALAQRQGASTFMLLLASFQALLYRYSGQSDIRVGVPVANRNRVETERLIGFFVNTQVLKADIDGQMGFDRLLHQVRQRSLEAQAHQDLPFEQLVEALQPERSLSHSPLFQVLFNYQAERGEHGLPEVAGLSIEEQAWESHTAQFDLVLDTCESESDIWAALVYATDLFDASTAERLVRHWQNLLDAILAMPDARLGELDMLDREEREVIGQLWNRSDSGYPATPLVHQRVAERARMAPDAVAVIFDEEKLTYAELDNRANRLAHALIARGVGPEVRVAIAMQRSAEIMVAFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLLTHSHLLERLPIPEGLSCLSVDREEEWAGFPAHDPEVALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIAHIVATGERYEMTPEDCELHFMSFAFDGSHEGWMHPLINGARVLIRDDSLWLPERTYAEMHRHGVTVGVFPPVYLQQLAEHAERDGNPPPVRVYCFGGDAVAQASYDLAWRALKPKYLFNGYGPTETVVTPLLWKARAGDACGAAYMPIGTLLGNRSGYILDGQLNLLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPFGAPGSRLYRSGDLTRGRADGVVDYLGRVDHQVKIRGFRIELGEIEARLREHPAVREAVVVAQPGAVGQQLVGYVVAQEPAVADSPEAQAECRAQLKTALRERLPEYMVPSHLLFLARMPLTPNGKLDRKGLPQPDASLLQQVYVAPRSDLEQQVAGIWAEVLQLQQVGLDDNFFELGGHSLLATQVIGRLRERLHLEVPIKSMFTAETLGEFCHGVETLKAESAPVEDALAKSLEALKRLSADELEKLIS
Protein: Probable WRKY transcription factor 57 (WRKY DNA-binding protein 57) (Q9C983)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein TIFY 6A
- Auxin-responsive protein IAA29
- Protein TIFY 5A
- Sigma factor binding protein 2, chloroplastic
- Senescence-specific cysteine protease SAG12
- Transcription factor GTE10
- Sigma factor binding protein 1, chloroplastic
Sequence:
MNDPDNPDLSNDDSAWRELTLTAQDSDFFDRDTSNILSDFGWNLHHSSDHPHSLRFDSDLTQTTGVKPTTVTSSCSSSAAVSVAVTSTNNNPSATSSSSEDPAENSTASAEKTPPPETPVKEKKKAQKRIRQPRFAFMTKSDVDNLEDGYRWRKYGQKAVKNSPFPRSYYRCTNSRCTVKKRVERSSDDPSIVITTYEGQHCHQTIGFPRGGILTAHDPHSFTSHHHLPPPLPNPYYYQELLHQLHRDNNAPSPRLPRPTTEDTPAVSTPSEEGLLGDIVPQTMRNP
Protein: Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (O88583)
Organism: Rattus norvegicus (Rat)
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Interaction partners:
- Tyrosine-protein kinase
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase
- Interleukin-6 receptor subunit beta
- Leptin receptor
- Insulin receptor substrate 2
- Insulin receptor substrate 1
- Signal transducer and activator of transcription 3
- Signal transducer and activator of transcription
- Insulin receptor
Sequence:
MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVETQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFSLPPTEPSFEVQEQPPAQALPGGTPKRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
Protein: Choline transporter-like protein (Q38AT4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU368066}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU368066}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MMQGFPSLGEKDPAAKPPAEGKPTSASGEKQPSEAVQGIPLYQGDGDDKEGLKRFVVQGYKDVWAAILYILCIFAIAGIGVHAMWSRGSSEEKQEVKKTTAENEPSNSKSLWSVYFLVGVAAAASIGAASVSFLLMRMFPRKTILFANIAAIIINIISALLAILSGHMVSGILMMTLCALHIMWFFFARHRIPFAAELLKASIDVLSGYKAVYLFNVMLCVGCTGLLMLWANAFMWTYQRSQAQDSSFSGIIYLFLMLFLFWTSQVTTNLMHVTTAGLTATWYFAGKENMPKNPTLASFKRGTTTSFGSICFGSLLVAIIRLIRWLVSTAEDSEHEILRCVFLCIIGCLERLMEYFNTYAFVHVAIYGCGYIEAAKMTWELCKQCVFSALFNDTLIDVTLGLLATCGSLLVGSVFGFLLKSWAAFALGFAVSILVHLLIFSPVGSAVTTLFVCYAEVPEGLEHSSPDLYAALQRTDQNGTSNGAAPPRV
Protein: Senescence-induced receptor-like serine/threonine-protein kinase (FLG22-induced receptor-like kinase 1) (O64483)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in innate immune response of plants.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- NDR1/HIN1-like protein 10
- Protein VACUOLELESS GAMETOPHYTES
- Probable WRKY transcription factor 29
- WRKY transcription factor 6
- Cytochrome P450 81F2
- Isochorismate synthase 1, chloroplastic
- Probable WRKY transcription factor 30
- WRKY transcription factor 22
- Regulatory protein NPR1
- Probable WRKY transcription factor 33
Sequence:
MAMLKSLSSILFTSFALLFFLVHAQDQSGFISIDCGIPDDSSYNDETTGIKYVSDSAFVDSGTTKRIAAQFQSSGFDRHLLNVRSFPQSKRSCYDVPTPRGKGFKYLIRTRFMYGNYDDLGRVPEFDLYLGVNFWDSVKLDDATTILNKEIITIPLLDNVQVCVVDKNAGTPFLSVLEIRLLLNTTYETPYDALTLLRRLDYSKTGKLPSRYKDDIYDRIWTPRIVSSEYKILNTSLTVDQFLNNGYQPASTVMSTAETARNESLYLTLSFRPPDPNAKFYVYMHFAEIEVLKSNQTREFSIWLNEDVISPSFKLRYLLTDTFVTPDPVSGITINFSLLQPPGEFVLPPIINALEVYQVNEFLQIPTHPQDVDAMRKIKATYRVKKNWQGDPCVPVDYSWEGIDCIQSDNTTNPRVVSLNISFSELRGQIDPAFSNLTSIRKLDLSGNTLTGEIPAFLANLPNLTELNVEGNKLTGIVPQRLHERSKNGSLSLRFGRNPDLCLSDSCSNTKKKNKNGYIIPLVVVGIIVVLLTALALFRRFKKKQQRGTLGERNGPLKTAKRYFKYSEVVNITNNFERVIGKGGFGKVYHGVINGEQVAVKVLSEESAQGYKEFRAEVDLLMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYLAGKRSFILSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSFSVEGSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYSLGVVLLEVITGQPAIASSKTEKVHISDHVRSILANGDIRGIVDQRLRERYDVGSAWKMSEIALACTEHTSAQRPTMSQVVMELKQIVYGIVTDQENYDDSTKMLTVNLDTEMVPRAR
Protein: Protein DETOXIFICATION 56 (AtDTX56) (Multidrug and toxic compound extrusion protein 56) (MATE protein 56) (Protein RESISTANT TO HIGH CARBON DIOXIDE 1) (O49660)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Could function as a HCO(3)(-) -sensing component in the CO(2) signaling pathway in guard cells. Acts as an upstream repressor of HT1. Plays a role in stomatal response to CO(2).
Subcellular location: Cell membrane {ECO:0000269|PubMed:25599916}; Multi-pass membrane protein {ECO:0000269|PubMed:25599916}.
Interaction partners:
- Serine/threonine/tyrosine-protein kinase HT1
- Guard cell S-type anion channel SLAC1
- Beta carbonic anhydrase 4
- Protein unc-13 homolog
- Mitogen-activated protein kinase 12
- LRR receptor-like serine/threonine-protein kinase GHR1
- Serine/threonine-protein kinase SRK2E
- E3 ubiquitin-protein ligase CIP8
- Aluminum-activated malate transporter 12
- Beta carbonic anhydrase 1, chloroplastic
Sequence:
MSETSKSESLDPEVSEGLCSKTLMQSIVHELKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTGFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFMAVLLLLLISVPISFLWLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLHIPINIVLSKARGIEGVAMAVWITDFIVVILLTGYVIVVERMKENKWKQGGWLNQSAQDWLTLIKLSGPCCLTVCLEWWCYEILVLLTGRLPNPVQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALVMIAFRGFWGSLYTHHDQLILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLGATLAFKAKQGLQGFLIGLFVGISLCLSILLIFIARIDWEKEAGKAQILTCNTEDEQTSQGSGQDSHS
Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (A0A8I6G2I8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
Interaction partners:
Sequence:
MNNSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDIDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLHLHYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGQSSQFGDEKTFNDPSLLENLQNNHPTAPIICEFLTMMAVCHTAVPERDGEKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSSRKRMSVVVRTPSGKLRLYCKGADTVIYERLAESSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFEEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCRLLRRNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMVHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTVFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAVPMAPDMSGEAAMLFSSGVFWVGLLSIPVASLLLDVLYKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHGYAFSQDENGIVSQSEVIRAYDTTKQRPDEW
Protein: Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) (O14733)
Organism: Homo sapiens (Human)
Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE.
Subcellular location: Nucleus. Cytoplasm {ECO:0000250}.
Interaction partners:
- C-Jun-amino-terminal kinase-interacting protein 1
- C-Jun-amino-terminal kinase-interacting protein 2
- Mitogen-activated protein kinase 8
- C-Jun-amino-terminal kinase-interacting protein 3
- Mitogen-activated protein kinase kinase kinase 7
- Mitogen-activated protein kinase kinase kinase 11
- Mitogen-activated protein kinase kinase kinase 1
- Mitogen-activated protein kinase kinase kinase 13
- Growth arrest and DNA damage-inducible protein GADD45 beta
- Mitogen-activated protein kinase 9
Sequence:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
Protein: BTB/POZ domain-containing protein 18 (B2RXH4)
Organism: Homo sapiens (Human)
Function: Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:A0A0A6YY25}.
Interaction partners:
Sequence:
MCSPASPKILYRNPRFLRLAFLQLHHQQQSDVFCDVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQGGKVVLELGGLKISTLRKLVDFLYTSEMEVSQEEAQDVLSAARQLRVSELESLQLEGGKLVKAPQGRRLNRECLQPTSAAPISARVVTPSHHPHTPLPTNQTPCPLGAIRLKSLGKEEGPQENNRQNADNLSGTLLLKRKARACPTPQEKNSSPSSHSQEPRENKNDTALDPTVLSPPSLYPSVDKHLLPRKIRLSRSKPSPGICTSKPSSILSGSSSVPATPGRRLWRQRSVNKETPEDKPKPGRASPLQSTPNPSGLGKTGGSRKRSPEVRAPNSDSAEEGQVGRVKLRKIVNGTCWEVVQETPLKNTQDSPQIPDPGGDFQEPSGTQPFSSNEQEMSPTRTELCQDSPMCTKLQDILVSASHSPDHPVVKSEFESSPELVEKEPMLAIDCREPYAFDTALLEQPCEAEEYRITSAAATSELEEILDFMLCGSDIEPPIGSLESPGAEGCRTPTYHLTETGKNWIEGEEWCLPDMELWPRELTELEKEPAGENRGPTELLSPLVMPSEVSEVLSVGGRWTPDLEITSSQPLDGQEDKLLHVSSLDTPQRSYGDLSPPCSNWVETGLEVSLTTDELLYPSPKAGKEVSGHSELLGSLPASSEEEEIDVVDWTAEGRLVPTTVPSVWPDPSSESETEVDILT
Protein: Probable serine protease EDA2 (EC 3.4.-.-) (Protein EMBRYO SAC DEVELOPMENT ARREST 2) (Q1PF50)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in a proteolytic pathway controlling the nuclear division phase of megagametogenesis.
Subcellular location: Secreted {ECO:0000305}. Note=Prediction of a peroxisomal location. {ECO:0000269|PubMed:15333753}.
Interaction partners:
- Carboxyl-terminal proteinase-like protein
- Uncharacterized protein T14D3.50
- Probable LRR receptor-like serine/threonine-protein kinase At1g51810
- Pathogenesis-related thaumatin superfamily protein
- UBP1-associated proteins 1A
- Probable disease resistance protein At1g63360
- DGCR14-like protein
- Putative disease resistance protein At1g63350
- Probable lysophospholipase BODYGUARD 2
- Ras-related protein RABG3a
Sequence:
MSLEFGFILINIFTAIVSFSTLSHALLHPSSVSHNVSRSRYYMTTNELWFNQTLDHESPNDHRKFRQRYYEFMDYFRSPDGPMFMIICGEGPCSGIANDYINVLAKKFQAGVVSLEHRYYGKSSPFNSLATENLKYLSSKQALYDLASFRQYYQESLNKKLNISSGGSDNPWFFFGISYSGALSAWFRLKFPHLTCGSLASSAVVRAIYEFSEFDQQIGESAGQECKLALQETNKLLELGLKVKNKAVKSLFNATELDVDADFLYLTADAAVMAFQYGNPDKLCVPLVEAKKNGSDLVVTYSTYVREYCMRIWGLRVRTYNRKHLRNTVVTADSAYRLWWFQACTELGYFQVAPKYDSVRSHQINTTFHLDLCKSLFGKDVYPKVDATNLYYGGDRLAATKIIFTNGSEDPWRHASKQNSTHEMPSYIIKCRNCGHGSDIRGCPQSPMVIEGKSNNCSLPDYVNKVRQQMVEHIDLWLSECRQSIRSSI