wanglab/gogpt-training-data huggingface dataset:
Protein: AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1) (Q99856)
Organism: Homo sapiens (Human)
Function: Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:17400556}. Cytoplasm {ECO:0000269|PubMed:17400556}. Note=Shuttles between nucleus and cytoplasm.
Interaction partners:
- Cellular tumor antigen p53
- Tyrosine-protein kinase BTK
- AT-rich interactive domain-containing protein 3B
- AT-rich interactive domain-containing protein 3C
Sequence:
MKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAPDEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDEEGLGPPGPASLGTTALFPRKAQPPQAFRGDGVPRVLGGQERPGPGPAHPGGAAHVAPQLQPPDHGDWTYEEQFKQLYELDGDPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGSLFAYSPGGAHGMLSSPKLPVSSLGLAASTNGSSITPAPKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREKLESAEPPEKKMALVADEQQRLMQRALQQNFLAMAAQLPMSIRINSQASESRQDSAVNLTGTNGSNSISMSVEINGIMYTGVLFAQPPAPTPTSAPNKGGGGGGGSSSNAGGRGGNTGTSGGQAGPAGLSTPSTSTSNNSLP
Protein: DNA-Binding protein G5P (G5P) (Single-stranded DNA-binding protein) (P69544)
Organism: Enterobacteria phage M13 (Bacteriophage M13)
Function: Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single-stranded (progeny) viral DNA, prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane.
Interaction partners:
Sequence:
MIKVEIKPSQAQFTTRSGVSRQGKPYSLNEQLCYVDLGNEYPVLVKITLDEGQPAYAPGLYTVHLSSFKVGQFGSLMIDRLRLVPAK
Protein: Cell division control protein (P91155)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR001767}.
Interaction partners:
- DNA replication licensing factor mcm-5
- DNA replication licensing factor MCM7
- Origin recognition complex subunit 1
- ORC
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM2
- DNA replication licensing factor mcm-6
- DNA replication licensing factor mcm-4
- CDT1 Geminin-binding domain-containing protein
- Origin recognition complex subunit 5 C-terminal domain-containing protein
Sequence:
MSSKSGSTRKSQRARDFEESEETEKPSLTRRKSSRLSTQSVPIEKKKTPSSKTTKRVPVSERVFHEEVESSSEDELLPQTKMASEEKRKLLLSPGSSLADRVEKLEISSPRARGRPRKATNLKSQLTTPRTPEKQSRSRSGSQGTPEKKSRKESSSESDSEEIISTSSEGALKGRREEFDSLKLWIMKSKETNTSLSIYVSGQPGTGKTATTMRVLKSLGKSVRSCIVNCASTNTKSALFKTIFESLDLDGKPNEEIFEKHVKQFKTPLVLVLDEIDHLANRKNAALYAAFQWPETLSRKIIILGIANSIDLTERLLPKLMLAKPPKRLVFEPYTKDDIVEILNDKMKNEETSIDAKAIELTARKVAAMSGDLRTALHIFKQQKSRMIPDDSKVPGTPVNGCREVLGIINNVYSSPLARARLPLQPRILLAVSLTLSANKKCTFDRNSLLRAYYKACEALRMPALDDDELHSAFQTLESQSFVRQLNGGKLVLQVDAPTAKSAISDNAMLDQIGLLQF
Protein: AMP deaminase (EC 3.5.4.6) (Q76NQ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MERNDADINFQRVSISGEDTSGVPLEDLERASTLLIEALRLRSHYMAMSDQSFPSTTARFLKTVKLKDRINNLPVKEVSDVHLRHSPMKITNPWNVEFPNDEDFKIKPLNGVFHIYENDDESSEIKYEYPDMSQFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMHVLLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVVTVTNGQQMTLAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLREVFLKTDNYLNGKYFAQIIKEVAFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNKMMKSFQEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPENPLFDNDVPRPEEWTYEENPPYAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRYETLLDELSNIFKVNQTCSIADMNAT
Protein: Mid-cell-anchored protein Z (A0A0H2UNG3)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Subcellular location: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01941}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01941}. Note=In newborn cells, forms a ring positioned at mid-cell. Soon after cell division starts and the cells begin elongating, the ring splits into two rings that, as elongation proceeds, move along and mark the future division sites. {ECO:0000256|HAMAP-Rule:MF_01941}.
Interaction partners:
Sequence:
MSKKRRNRHKKEGQEPQFDFDEAKELTVGQAIRKNEEVESGVLPEDSILDKYVKQHRDEIEADKFATRQYKKEEFVETQSLDDLIQEMREAVEKSEASSEEVPSSEDILLPLPLDDEEQGLDPLLLDDENPTEMTEEVEEEQNLSRLDQEDSEKKSKKGFILTVLALVSVIICVSAYYVYRQVARSTKEIETSQSTTANQSDVDDFNTLYDAFYTDSNKTALKNSQFDKLSQLKTLLDKLEGSREHTLAKSKYDSLATQIKAIQDVNAQFEKPAIVDGVLDTNAKAKSDAKFTDIKTGNTELDKVLDKAISLGKSQQTSTSSSSSSQTSSSSSSQASSNTTSEPKPSSSNETRSSRSEVNMGLSSAGVAVQRSASRVAYNQSAIDDSNNSAWDFADGVLEQILATSRSRGYITGDQYILERVNIVNGNGYYNLYKPDGTYLFTLNCKTGYFVGNGAGHADDLDY
Protein: C2HC/C3H-type domain-containing protein (Q381C5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSQHRDPCDDNSTKARVRLHTSSVRRTQAPQTATEANSHAGRDSAGARATPIVTRGLYSLLEDEIHSNKTPRKVAAARKAGPGSRPQFLFCYLCGQQFSRVSLPIHQPQCYVKKLIEWERMDPLKRGPRPMSPKSHEENLKAMPAVEQSIGKGADKGTKLAGRELDRFNELQIEHFNKNMLLKCETCGRTFLPDRLEVHQRSCKPGSASASRPVGRAVAKSATPNKTRRLAAEPATARRKEKLIPKAFPQDKEEEIDAVADVGDEVKEGEPGLLDPTTLSQTPRPSGDPDNAPNGEEQQPSTEEKSGLEAVSVARHRVEMKASHSSPQVGSLVDYLDQDIERLKICDDVGAVTPRARSPPRDETSRARYSLKSSLGSTVSKNDRTSVSLRRSEVPASSEVAGNTSVSVDSRGGDDEVSPAAPAKKIQLNNVSHFKNVQSRLNLGAKKEELPRCRFCNRTFNADRLQKHESVCLERHKAPPKSARPSATPNAAGKVVKKEVKPLTARGVAAKPVLHEQAVMAPSNPPRKSEPALDAAGRSSLETPLAPSATSARLPTDKRLSVSSLTHPTTAEGTHDVGSTEGAPRIRYCFECGLKLPFESQRFCSGCGTKLVVDA
Protein: YME1-like 1 (S. cerevisiae) (Q96I63)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHS
Protein: Glutamate receptor 2.7 (Ligand-gated ion channel 2.7) (Q8LGN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glutamate-gated receptor that probably acts as non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Sulfate adenylyltransferase subunit
- V-type proton ATPase subunit c4
Sequence:
MKVMNPRKTNNTFMYYFVLFVCGFVLMEGCLGQNQTTEIKVGVVLDLHTSFSKLCLTSINISLSDFYKYHSDYTTRLAIHIRDSMEDVVQASSAALDLIKNEQVSAIIGPRTSMQAEFMIRLADKSQVPTITFSATCPLLTSINSPYFVRATLDDSSQVKAIAAIVKSFGWRNVVAIYVDNEFGEGILPLLTDALQDVQAFVVNRCLIPQEANDDQILKELYKLMTMQTRVFVVHMPPTLGFRFFQKAREIGMMEEGYVWLLTDGVMNLLKSNERGSSLENMQGVLGVRSHIPKSKKLKNFRLRWEKMFPKKGNDEEMNIFALRAYDSITALAMAVEKTNIKSLRYDHPIASGNNKTNLGTLGVSRYGPSLLKALSNVRFNGLAGEFELINGQLESSVFDVINIIGSEERIIGLWRPSNGIVNAKSKNTTSVLGERLGPVIWPGKSKDVPKGWQIPTNGKMLRVGIPVKKGFLEFVDAKIDPISNAMTPTGYCIEIFEAVLKKLPYSVIPKYIAFLSPDENYDEMVYQVYTGAYDAVVGDVTIVANRSLYVDFTLPYTESGVSMMVPLKDNKNTWVFLRPWSLDLWVTTACFFVFIGFIVWILEHRVNTDFRGPPHHQIGTSFWFAFSTMNFAHREKVVSNLARFVVLVWCFVVLVLIQSYTANLTSFFTVKLLQPTVTNWKDLIKFNKNIGYQRGTFVRELLKSQGFDESQLKPFGSAVECDELFSNGTITASFDEVAYIKVILSQNSSKYTMVEPSFKTAGFGFVFPKKSPLTDDVSRAILNVTQGEEMQHIENKWFKKPNNCPDLNTSLSSNHLSLSSFWGLFLIAGIASFLALLIFVANFLYEHKHTLFDDSENSFRGKLKFLVRNFDEKDIKSHMFKENAVHNVSSPITQGSSSPLTDQSTPLPRSPEQYRELELRRVSSISSGELFTTQSEQVEDEESAIIQCEGE
Protein: Rrp41p homologue (Q95Z09)
Organism: Trypanosoma brucei
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MATISRRDGRTAREMRGKELRTSDLSQFDGSAWYSQGLTAVTVAINGPTAARQENYRRCTTCIHVNRAARIPQEGGTGRLIMMERRERERCEDGELKQFLTSLVEAIVCLDRFPRCVLEAHVTVLMDDGALFAVASNAIMCALLDAGVPCRSTIAAVSLIMCNPEASGNEGEPEIFLDPTAVEESTDEVRSYASATFVLTNTGGEAVLASRVQARPRSSAYSRPITPKDLSRMFALAAKAAETLFVFFRNCSMALE
Protein: Pantothenate kinase 1 (AtPANK1) (EC 2.7.1.33) (AtCoaA) (Pantothenic acid kinase 1) (O80765)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration. Functionally redudant with PANK2.
Interaction partners:
- Phosphopantothenate--cysteine ligase 1
- Phosphopantothenoylcysteine decarboxylase
- Phosphopantetheine adenylyltransferase
- Pantoate--beta-alanine ligase
- Probable phosphopantothenoylcysteine decarboxylase
- Pantothenate kinase 2
- Damage-control phosphatase At2g17340
- AT2G17320 protein
- Alkaline-phosphatase-like family protein
- At4g35360/F23E12_80
Sequence:
MDPTQISHLALDIGGTLIKLVYFSANGDYSEESRNGCSVVKGRLCFAKFETRKIDDCLEFIRFNILHHSGVQQPNGEGHDKLYVKATGGGAFKFADLFKEKLGILFDKEDEMCSLVGGVNFLLKTVPREAFTYLDGQKKFVEIDHNDLYPYLLVNIGSGVSMIKVDGDGKYERISGTSLGGGTFLGLGKLLTKCKSFDELLELSHHGNNRVIDMLVGDIYGGTDYSKIGLSSTAIASSFGKAISDGKELEDYQPEDVARSLLRMISNNIGQIAYLNALRFGLKRIFFGGFFIRGLEYTMDTISVAVHFWSRGEAKAMFLRHEGFLGALGAFTSYNDQSHNDLKPHHHTVQRAILNCSGHNFRHIPVTSNLNESETIECSINLV
Protein: TSET complex member tstE (Protein TTRAY1) (Q54YB3)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MLKIGICSSITISNSISNSYHSPSTSTVVVGNQLQQQQQQQQYVQQQLQYQYDSLNQSQTSPNSNDGNIGGGSGGGNNAGSNIGIGGGGGGNNNNIGGGGGSGGGVNIGSGSGGGGSGSNSNIGGGGGGGQLGMNGMNGSNMLLINQNIPTIKSTDSIGSTVSINSTGVSLQYNSLSSTIGSPSSLSLLSPIISNPFSSTLPNQSYMVNQILFNCLCFHPKSPILYAAIRNEVHFYDIITKSVIGKLFIDPTETIRHLITLPGNSIQTPTFLLAFTQEGVIYLWDPETHKLQTIVHQLKLDDKRPITCKSAAPNKPVIFFSKNESKDIVVVDFHNKGSSPFKLKGHKKPISAIAHHPAKTILASCSTDGQLKIWDTRNNMSFLNFEEFSSYENTRNIEHSNHYFLVFEPTGKYLVMTGSSGLTLVYGDLTSQNPQEVIANGFICKGQNILSIVHHPQLPLFFVLSIGPSGYEELSSWEINNQYKTIVQSPLIPTFIPEINDSLSYLSKYSKPLTIPKFNPVSIVIHPTKNYFSLQLEASSNISSTISPYPSNINSQPFSSIRHINQNIYSINSYDHLNHSFPLVSKLPLPMGFFFEPENTFNYPSEITFFDGTYVKSYLPLNGITKKLIDTPIMVNSASGMGSGGGEDISKGKKFLFNNEFQLFALIYDSFSVAAQAQLSKYLIMDLQGLVNQQGDGSDCVFIGNNQQILILGLDGKLAKVATLSKQGVSSFKNFTLVPRITSVHSTPLGGNKVVLYFCQEKSCLVFSKNVNQSDPSCKDNYMVDIDGDNGILQLQPNEKVFQIEWQSDPKSSQHICAILTNQRIIITNSRLRIINQIHSPPNHHQSTSSYFQSIFWLEWTLLYTTSTHLMYMTLQNNQAPKPISTLSISPIILSTILPDRMIFGYQGLQVPGKNETTVRCQAIGILECLIIGLLSLPPFIQYEKKYLSSCLQNIVQKLDYTRISKHVLDKLRERSFTDLAYSLSNDMKISQSKQSSLEKFRMAWISKQYEAANRHLSIEFNRISIIKNPNDTEKRQFNKLKENMRDFGRECMNAGHYLLAKDCFQKLSEHIYLLQISILLNDRDSVIAIKRDAELRGDDHVLLAACDKYLNKQNKSINKVNPPVVKILPWDPTATTNVSMKSGLDYLSPINLNSIQRYYPISLPFSGASASLNGGKHKLLRPPEESWPPEDFKHSVAITPPRTLMSLVANRLSTKSHMSSTTTLRRSPSIENIRTTSTTFDSSKFNTDNQELFDDDSDDDSDSGADADVDSENEEDRKLVMTVPASLQHNDNSSLTNITVTDNDSNLDQDITSNTGSDIADLNDTQLSSTPTPTTTLSS
Protein: Oligodendrocyte transcription factor 2 (Oligo2) (Q9EQW6)
Organism: Mus musculus (Mouse)
Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
Subcellular location: Nucleus. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
Interaction partners:
- DNA-binding protein inhibitor ID-4
- Homeobox protein Nkx-2.2
- Transcription factor SOX-10
- Glial fibrillary acidic protein
- DNA-binding protein inhibitor ID-2
- Paired box protein Pax-6
- Myelin basic protein
- Nestin
- RNA binding protein fox-1 homolog 3
- 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Sequence:
MDSDASLVSSRPSSPEPDDLFLPARSKGGSSSGFTGGTVSSSTPSDCPPELSSELRGAMGASGAHPGDKLGGGGFKSSSSSTSSSTSSAATSSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPTATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLSSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGGSGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGTLPRLTSDAK
Protein: Protein sel-1 homolog 3 (Suppressor of lin-12-like protein 3) (Sel-1L3) (Q68CR1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Derlin-1
- Endoplasmic reticulum-Golgi intermediate compartment protein 2
- Derlin-3
- E3 ubiquitin-protein ligase synoviolin
Sequence:
MQRRGAGLGWPRQQQQQPPPLAVGPRAAAMVPSGGVPQGLGGRSACALLLLCYLNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVEYLCSQPCVVNLEAVVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHSISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLLQTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELEATRRQRMDYPVFTVSLWLYLLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTISFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEIVSVYASAAKHGGERQEACHLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSSCCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNIATKTPLDQHTLQGDQAYVETIRLKDDEILKVQTKEDGDVFMWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIFPGVPGRNQTLAGEYFHKAAQGGHMEGTLWCSLYYITGNLETFPRDPEKAVVWAKHVAEKNGYLGHVIRKGLNAYLEGSWHEALLYYVLAAETGIEVSQTNLAHICEERPDLARRYLGVNCVWRYYNFSVFQIDAPSFAYLKMGDLYYYGHQNQSQDLELSVQMYAQAALDGDSQGFFNLALLIEEGTIIPHHILDFLEIDSTLHSNNISILQELYERCWSHSNEESFSPCSLAWLYLHLRLLWGAILHSALIYFLGTFLLSILIAWTVQYFQSVSASDPPPRPSQASPDTATSTASPAVTPAADASDQDQPTVTNNPEPRG
Protein: 3'-5' exonuclease (EC 3.1.11.-) (Werner Syndrome-like exonuclease) (DmWRNexo) (Q9VE86)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction. Essential for the formation of DNA replication focal centers. Has an important role in maintaining genome stability.
Subcellular location: Nucleus {ECO:0000269|PubMed:18956248}.
Interaction partners:
- Exosome complex exonuclease RRP44
- DNA replication licensing factor Mcm5
- Dis3 like 3'-5' exoribonuclease 2, isoform C
- Exonuclease 1
- Proliferating cell nuclear antigen
- Recombination repair protein 1 endonuclease)
- ATP-dependent DNA helicase II subunit 2
- Putative lipoyltransferase 2, mitochondrial
- Protein MCM10 homolog
Sequence:
MEKYLTKMPIKSKANEVPKEEAGVKKETPKVARKATKKDTPKELKDKENAGDDNTPKQTKGRPGRPAAKRKNLDTPDVTEKLAMEEENPPKRRSSRLTRSTRSMAEDGSPSPEKEKPEKLPFIKYKGAIKYFTESQDIAASADDVLQWVEKQKDEVVPMAFDMEWPFSFQTGPGKSAVIQICVDEKCCYIYQLTNVKKLPAALVALINHPKVRLHGVNIKNDFRKLARDFPEVTAEPLIEKCVDLGLWCNEVCETGGRWSLERLTNFIAKKAMDKSKKVRMSKWHVIPLDENQLMYAAIDVYIGQVIYRELERREKVKIKNEEEFKEKNGDAAFKAMKALGETFLTKINEVTL
Protein: Tubulin-specific chaperone A (E5RJD8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|RuleBase:RU364030}.
Interaction partners:
Sequence:
MLTRTSWFHGFFSWFSSSICWSTLSKFLRLVKEKVMYEKEAKQQEEKIEKMRAEDGENYDIKKQAEILQESRMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA
Protein: Stardust, isoform G (EC 2.7.4.8) (E2QD98)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Patj homolog
- Protein crumbs
- Protein lin-7 homolog
- Atypical protein kinase C
- LD29223p
- Moesin/ezrin/radixin homolog 1
- Bazooka, isoform B
- Protein disks lost
- Exocyst complex component 2
- Cadherin-86C
Sequence:
MQANSSRSNLSAQSSGTPSASTISSSQGKQQVVELSGYVIILVENVEGKIKLYGSPPDRDNLEVGDEILEVNGLTLENISRTEVIRHIHDCIKSCTICLRVRKKNDSRLAWDIGNSVQDAFVIAVEEHARERLQRLAALNRVTPVDITQLSKKLQQTKSGTATSQRQDLSFLNESTPIYVTSFTSNQITCSSSTMTTATAGGPISAPSLATATTTVPTASSHTTTVVAQIEHGASALVSAAVAAATAADRNANSTTSAALKQTANCIGNSTSSLGTTSTTSSQSTSSATGHIYQTSQAQQQQLQQLQQQLAAAAAAGKPLQAKSLLASSLQHLAEEVDNEDLDDDDDVDGANYCGITYISYNNKHAQLPTTTLPATTALPAAAASLATTAAIYQQRQQQQHQQQQQQQQQPVHHHNHPPTASQLNRATAPAPLQLGGPVNPSFVDAQTSTSPLMAQQLHSQHADVDAAPPSSSSSSAVVVVERHVHGTTTPKTEYSTAISSGQLQQAFAELQLHSSNNNATQQQQQHLLLSNNNNSNNSMAAAQTTASLMKNCDLLISNNLYPPRRELLEDVIVHQASDVHSYSTSASAAAIASSSNRSQQQQQQQQQHQLLSAAYELQQQQQLQLQQQQQQQNSPTSSISIGRTELLLGDQSLRQDPRGNRRRSGSSIVVLDGDDLKPCLPDDYISGQHHLNHQQQLQLQQQLQQQHPLQQQHYRTHSGDIREIDQEMLTMLSVNQDNGPHREMAVDCPDTFIARNKTPPRYPPPRPPQKHKKSTNTTTTTTITALTNNDHANKMLIVAYHSSHQHEQLQQQHPSKTSTTTTTIALDVATQNLYNQKQQNKLEQIENYENCLQSERNEQHEQQFEQQKQHQATTAMAATQVAQQQTPSHKLQATLSSDPNGNSNSNNNSHIVGISSSSSSNNSSITDDFLCVVDGLYQGRKDTASPSSSAFDEVMSKHTLDSFGSIAYRHLHQQHQATSNGNSSSNTSNTNSNTNSNTNSNSNTNGNTSNNTAVSTKTATVTKTGVSSSNSNSNSLNSSNSSMHTSSSSSGHSSNIASATSSSSATSSSTVPDDLSLAPPGYEVSQQQQQQHLVATPVTMLLPPMAKHRELPVDVPDSFIEMVKTTPRYPPPAHLSSRGSLLSNGSASTAHTTLSSMGVAPSPVTATAAAAASASAACATTAVAAAAVSGVADGDARRVADELNGNAKPVPPPRDHLRVEKDGRLVNCSPAPQLPDRRAPGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQLRRRREEEERIAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGEEDQTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRHELRQRLMADSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVHNNRDES
Protein: At2g37930 (Q8GXY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MRNQSFSVRSQAFSDATDADTVMRVDQKGKREHQLLSMKQKELSHASELSSCISPGSEKFRTVECQDRRHDVEGECSSPVSVMERNQEKPCLLDQNIPTMSSKKERDPSPNRRFSFSFSQMSRSFSSKESSSSLSSTSHASAKSGPLTFTNSVYTTHSTRTKSNGHNRTRSGPILKPKTEKNNVPSLQVASKPSNTRPPTKEKKQSSSRVHALLQFTLRKGINLFQFVVGDNSNNVLAATMKSSDSSTRSYTLYTVNEVKNKTGNWLSRHKNEHPFVHTIIGEMKTVTTFTSDSSIHKSETVLFGVDSTNEELAAIVQTRNTTTIILPSGVHTLPKDGNNSPLPLINRWKTGGECDCGGWDIGCKLRVLSYNHTKTQTLSSFQLFDQERDEPAFKMVSHGDELHSVEFGSSISLLEAFFISLAVTSHQSWCQEEEEEEVVVIGDCLLKRETPAKYATNPPVSPIGRV
Protein: Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2) (O08954)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O43623}. Cytoplasm {ECO:0000250|UniProtKB:O43623}. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions (By similarity). {ECO:0000250|UniProtKB:O43623}.
Interaction partners:
- Cadherin-1
- Lysine-specific histone demethylase
- Twist-related protein 1
- Catenin beta-1
- Cadherin-2
- Cellular tumor antigen p53
- Paired amphipathic helix protein Sin3a
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 4
- Transcription factor SOX-9
Sequence:
MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLCESYPMPVIPKPEILTSGAYSPITVWTSAVPFHSPLPSGLSPLTGYSSSLGRVSPLPSSDTSSKDHSGSESPISDEEERLQPKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQARKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH
Protein: Nuclear receptor subfamily 4 group A member 1 (Nuclear hormone receptor NUR/77) (Nuclear protein N10) (Orphan nuclear receptor HMR) (P12813)
Organism: Mus musculus (Mouse)
Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury.
Subcellular location: Nucleus {ECO:0000269|PubMed:2555161, ECO:0000269|PubMed:30134173}. Cytoplasm, cytosol {ECO:0000269|PubMed:37001519}. Mitochondrion {ECO:0000250|UniProtKB:P22736}. Note=Nuclear export to the cytosol is XPO1-mediated and positively regulated by IFI27. Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (By similarity). {ECO:0000250|UniProtKB:P22736}.
Interaction partners:
- Apoptosis regulator Bcl-2
- Retinoic acid receptor RXR-alpha
- RAC-alpha serine/threonine-protein kinase
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 7
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- Mitogen-activated protein kinase 1
- Protein c-Fos
- RAC-beta serine/threonine-protein kinase
Sequence:
MPCIQAQYGTPATSPGPRDHLTGDPLALEFGKPTMDLASPETAPAAPATLPSFSTFMDGYTGEFDTFLYQLPGTTQPCSSACSSASSTSSSSSSATSPASASFKFEDFQVYGCYPGTLSGPLDETLSSSGSEYYGSPCSAPSPSTPNFQPSQLSPWDGSFGHFSPSQTYEGLWAWTEQLPKASSGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPPPATHQLGEGESYSMPAAFPGLAPTSPNRDTSGILDAPVTSTKSRSGASGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPSTAKLDYSKFQELVLPRFGKEDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELCPGDQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHQLQCARGFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDRHGLQDPRRVEELQNRIASCLKEHMATVAGDPQPASCLSRLLGKLPELRTLCTQGLQRIFCLKLEDLVPPPPIVDKIFMDTLSF
Protein: Putative ribonuclease L inhibitor (Q8MYK1)
Organism: Trypanosoma brucei
Interaction partners:
Sequence:
MPPKNRQDEEKSKLTRIAVVNHDRCKPAKCNLECSKCCPVNLQGKLCVVVQKKSTISVISEELCIGCGLCVKKCPYGAIQIINLPSNLNKDTVHRYGPNSFKLHRLPLPRPGQVLGLVGANGTGKSTALSILKGKTKPNLGRYKDEPSWEEILKYFRGSEHQAYFQHMLEQKMRVLLKPQYVDQVPKVTKGKVGDLLTKADDRGVKDYYMKELDIENVADRELEKLSGGELQRFTIAALCVQNASVYMFDEPSSYLDVRQRLMAAKVIRSLLKDDNYVVVVEHDLSVVDYMSDFVCVLYGVPGIYGVVTMPYGVREGINIFLDGFVPTENLRFRQESLSFRITDDLEETTKRSVQHSYPSMVKNLGGFTLTVESGSFSDSEIVVLLGENGCGKTTFIRMLAGHIKPDNEVEVPQLCISYKPQKIAPKFQGTVKDLLQSKIYEAFSNPQFQTDVLKPMTVEELYDQEVQHLSGGQLQRVGLCLALGTPANIYLIDEPSAYLDSDQRIIAARVIKRYIMHAKRTAFIVEHDFIMATYLADRVIVYDGTPAVNCKANAPCALLEGMNKFLKSLDITFRRDPSNFRPRINKFDSVKDREQKIAGNYFYMVEEVAKPVKPAKVDGEDEDEDDESNE
Protein: Regulatory factor X-associated protein (RFX-associated protein) (Q8VCG9)
Organism: Mus musculus (Mouse)
Function: Part of the RFX complex that binds to the X-box of MHC II promoters.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-binding protein RFXANK
- DNA-binding protein Rfx5
- MHC class II transactivator
- Cyclic AMP-responsive element-binding protein 1
- Protein NLRC5
- Ankyrin-2
- Ankyrin-3
- Ankyrin-1
Sequence:
MEAQAVPEGSGPSTASPRTAPPVTVLVMRQDEAEADGALRPGLAGSEAAADAEDEAGDDDADLLDTSDPAGGGESAASPEELEDEDAEGGGAARRRGSKTCTYEGCRETTSQVAKQRKPWMCKKHRNKMYKDKYKKKKSDQALGSGGPSAASTGNVKLEESTDNILSIVKQRTGSFGDRPARPTLLEQVLNQKRLSLLRSPEVVQFLQKQQQLLNQQVLEQRQQHFPGAPV