wanglab/gogpt-training-data huggingface dataset:
Protein: Signal transducer and transcription activator 6 (P52633)
Organism: Mus musculus (Mouse)
Function: Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Subcellular location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Interaction partners:
- Interleukin-4
- Interleukin-4 receptor subunit alpha
- Tyrosine-protein kinase JAK2
- Non-receptor tyrosine-protein kinase TYK2
- Tyrosine-protein kinase JAK3
- Signal transducer and activator of transcription 2
- Interferon regulatory factor 9
- Cytokine-inducible SH2-containing protein
- Cytokine receptor common subunit gamma
- Tyrosine-protein kinase JAK1
Sequence:
MSLWGLISKMSPEKLQRLYVDFPQRLRHLLADWLESQPWEFLVGSDAFCYNMASALLSATVQRLQATAGEQGKGNSILPHISTLESIYQRDPLKLVATIRQILQGEKKAVIEEFRHLPGPFHRKQEELKFTTALGRLQHRVRETRLLRESLQQGAKTGQVSLQNLIDPPVNGPGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFEESLAGLQERCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPMVRADMVTEKQARELSLAQGPGTGVESTGEIMNNTVPLENSIPSNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFTLGPNKLLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSVEAFQHRCVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVPPYDLGMAPDASMQLSSDMGYPPQSIHSFQSLEESMSVLPSFQEPHLQMPPNMSQITMPFDQPHPQGLLQCQSQEHAVSSPEPMLCSDVTMVEDSCLTQPVGGFPQGTWVSEDMYPPLMPPTEQDLTKLLLENQGEAGGSLGSQPLLQPSPYGQSGISLSHLDLRTNPSW
Protein: Methionine-R-sulfoxide reductase B1 (MsrB1) (EC 1.8.4.12) (EC 1.8.4.14) (Selenoprotein R) (SelR) (Selenoprotein X) (SelX) (Q9JLC3)
Organism: Mus musculus (Mouse)
Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14699060}. Nucleus {ECO:0000269|PubMed:14699060}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23911929}.
Interaction partners:
- Selenoprotein K
- Mitochondrial peptide methionine sulfoxide reductase
- Protein adenylyltransferase SelO, mitochondrial
- Thioredoxin reductase-like selenoprotein T
- Thioredoxin reductase 2, mitochondrial
- Selenoprotein S
- Selenide, water dikinase 2
- Selenoprotein W
- Selenoprotein F
- Selenoprotein N
Sequence:
MSFCSFFGGEVFQNHFEPGVYVCAKCSYELFSSHSKYAHSSPWPAFTETIHPDSVTKCPEKNRPEALKVSCGKCGNGLGHEFLNDGPKRGQSRFUIFSSSLKFVPKGKEAAASQGH
Protein: Wing blister, isoform C (Wing blister, isoform D) (Wing blister, isoform E) (Wing blister, isoform F) (M9MRU0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSASDKRTVKMSDASIKPRKLKKHLRAADVKPRGMMTKSLLLHLCVYLVCITQTLQLQQRQQQQQQQHRQQQHGQPEGNMLQQHHRTSVNSSVNINISRQFNEIIQTATASASASGTGSASGAVTFASVTAATTITPGRRKLRRKFQGQQNRNSTLGRRRKLRLHPYHRRNATHATRTTTVASVSATATTLLPKMPHKQPFNYHTHLHSSFQQQQQQQHVAGGQVTQQQQQQQQVHVVAVTPRPQQRQQQPGFAIVPATYYHQQQQQQQRTLLGNLTQQQQQQQQHLLIQPGQNILVYSNLGPIPPCPPGLLSGSGMPVYTQQQHFIPLRSTTTPRPRQRECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLESLGPKCIRSYLPASYGLSTSNKIRMSFALSNHLESSPLIHLASSEGRHITLELYKRRVRLVWNLGGTTATVTHPMVVHTRDPKYDDAWYHVEANRTLNLGSLVVRRMNNYGELTPPNPVIITGSTDTEHTRFYQSRSDRISLGGFASKDLQFTPGLNVVVHQVEVDNKPLGLWNFVTSEGSCGGSMVGAKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIEAAREFSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLSKTVYYLGGVPPGFTSGTSKAPGADNPFLGCMKDVQVNGETYDPLESSSYYGVEPSCKNMITKAGFSGNGYLELPSQSLRKRSNTALVFRTLQPDCLLLLAAYPPEILGDYDAKDIKGNFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGAPPHESYTPLAPTFVNLEGAIRDVVFNNRTINFNDALTFANVQIGRNGPLMGSLKGGLYDVLLKTEPMIGKSFTASPEGCKRIGSYSYEPNAFKFGDDIYSYSQLKLPERHFWQRNFHLSFDFRSFYPNGMLYLSPGSKEKPKHYVALVLKDGQLVLVVRGRRREELQLTAKLNDGEWHRVTISCHDRKVTMSVEIGRTDQKTSAQMKLPKKIGASQLLLVGGLPQSPVKVSSDLYVRLEPFKGCLRRVSINNNTQDLARPGKHSNVGQCFPTVERGSYFPGDAYAIYKKNFNVGKYLDLETEFRTSELSGILLSVSDPNGFPALSLELHNGNIIFSCDPGNGAPMRVESSLPTKYALCDNKWHNISALYDGEQIVLRIDQLPAVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSIRNERRDWIEMEDLRNVLLSECLVSSDES
Protein: Microtubule interacting and trafficking domain containing 1 (H7C3Q6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
LKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDGKYHKQIKIEENATGFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGIEQVQQSRGLQEIEESLRSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKHTKNI
Protein: Tubulin--tyrosine ligase (TTL) (EC 6.3.2.25) (Q9QXJ0)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Interaction partners:
- Enhancer of mRNA-decapping protein 3
- Small vasohibin-binding protein
Sequence:
MYTFVVRQENSSVYAEVSRLLLATGYWKRLRRDNPRFNLMLGGRNRLPFGRLGHEPGLAQLVNYYRGADKLCRKASLVKLVKTSPELSESCSWFPESYVIHPTNLKTPVAPAQNGIQLPVSNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEEFNQYLTSALNITLENSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLLGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDTEQVPQQPAAFMKL
Protein: COP9 signalosome complex subunit 5 (Dch5) (Signalosome subunit 5) (EC 3.4.-.-) (JAB1 homolog) (Q9XZ58)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis. Also involved in regulation of axis formation by checkpoint-dependent, translational control of Gurken.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:10531038}. Nucleus {ECO:0000305|PubMed:10531038}.
Interaction partners:
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 7
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 3
- Ubiquitin-like protein NEDD8
- COP9 signalosome complex subunit 1b
- COP9 signalosome subunit 1a
- Cullin-4A
Sequence:
MDSDAAQKTWELENNIQTLPSCDEIFRYDAEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHARSGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEYMTAYMEAAKEVGRMEHAVGWYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVDPVRTVSAGKVCLGAFRTYPKGYKPPNEEPSEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDRRLLDSLWNKYWVNTLGSSGLLTNTEYTTGQIMDLSEKLEQSENFLGRGTDVNEKRSEDKLSKATRDCSRSTIELIHGLMAQIVKDKLFNKVGLGK
Protein: Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) (P06174)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the fourth step in the heme biosynthetic pathway.
Interaction partners:
- Porphobilinogen deaminase
- Delta-aminolevulinic acid dehydratase
- Uroporphyrinogen decarboxylase
- 5-aminolevulinate synthase, mitochondrial
- Uroporphyrinogen-III C-methyltransferase
- C-4 methylsterol oxidase ERG25
- Protoporphyrinogen oxidase
- Oxygen-dependent coproporphyrinogen-III oxidase
- Lanosterol 14-alpha demethylase CYP51
- Ferrochelatase, mitochondrial
Sequence:
MSSRKKVRVLLLKNKTVPIDKYELECRSKAFEPIFVPLIKHTHVIQDFRNVLNTIPNYLNTINYIIITSQRTVESLNEAIIPTLTSEQKAALLSKTVYTVGPATANFIRRSGFINVKGGEDAGNGSILADIIIDDLSTDIKACPPSELLFLVGEIRRDIIPKKLHSKGIKVREVVTYKTEELSDGFKRFIHAMKECDEDEVFSDWVVVFSPQGTKEITQYLGDSNRLPGSHLRVASIGPTTKKYLDDNDVTSDVVSPKPDPKSLLDAIELYQRHK
Protein: Mitochondrial outer membrane protein OM45 (Outer membrane protein of 45 kDa) (P16547)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:11502169}.
Interaction partners:
- Non-selective voltage-gated ion channel 1
- Mitochondrial outer membrane protein OM14
- Mitochondrial import receptor subunit TOM70
- Mitochondrial import receptor subunit TOM22
- Meiotic sister chromatid recombination protein 1
- Inactive diphosphatase DCS2
- Reticulon-like protein 2
- Mitofusin FZO1
- Carboxypeptidase Y inhibitor
- Protein FUN14
Sequence:
MSSRIIVGSAALAAAITASIMVREQKAKGQRREGNVSAYYNGQEYGSSAPPQLGKLHNIKQGIKEDALSLKDALLGVSQKAREEAPKVTKRVISPEEDAQTRKQLGQKAKDSSSQSIFNWGFSEAERRKAIAIGEFDTAKKRFEEAVDRNEKELLSTVMREKKAALDRASIEYERYGRARDFNELSDKLDQQERNSNPLKRLLKNNTGDANTEEAAARSVQGWGDTAQEFGREELEEAKRNASSEPSEAQKRLDELKKIKEKGWFGYNKGEQSEQQIAERVARGLEGWGETAAQLSKDEMDDLRWNYENSKKQLDKNVSDAMDSLSKAKEDLKQYGSHWWSGWTSKVDNDKQALKDEAQKKYDEALKKYDEAKNKFKEWNDKGDGKFWSSKKD
Protein: Mitochondrial carrier protein, putative (Q388W2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSKETKAPANAPLPKVYTIGIAGFSGMFAWLFTHPYEMWKNTVMTAPKGTSQKECLVKVWERGPFRGLSTGILRQAVYAPARLGCYPIFRDAIMSLKGDADGMPTVAERALAGALAGVFSSILTSPVEVCLVLQMTGASKQSLTRAAITVYSTNGITGYWRGVSALASRAALVGVAQVAVHDQVLSALRRRNVSYSQLHGTQPYGDNIVVNAASILTALFYSVITMPVEFARVRMSADTTKAKYKSVTQTIGRVVREEGALAVYDSFAPYFFRCATHTVVCFFTIEYITRKVKGWRAAKLQAKQ
Protein: Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) (Q8IY84)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTAVYMNGGGLVNPHYARWDRRDSVESGCQTESSKEGEEGQPRQLTPFEKLTQDMSQDEKVVREITLGKRIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHHPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHENQIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIPTERYGIDCIMNDEWMQGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTLEHLGITEEHIRNNQGRDARSSITGVYRIILHRVQRKKALESVPVMMLPDPKERDLKKGSRVYRGIRHTSKFCSIL
Protein: Nuclear pore complex protein Nup75 (Nucleoporin Nup85) (A1YK00)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000256|ARBA:ARBA00004567, ECO:0000256|RuleBase:RU365073}.
Interaction partners:
Sequence:
MSDSGVFAFELGDDLATRCGNTLTGVFVPGSRIALSAYRHVTHSSRDEPTENAGQVPVLIYMAQESTLFDEPVLRSVLAEANATFATLQQLGSRATRAEYVNISRAYRSIVRSCLEKLEQAKKSPEVQTDEARLQRLCDAIVVFYAAECLWHLFEILYIQSNQLVVPQLLDWARFHSPHAEDRATDLLLMGEEASESDDYWSIVKSLIMLGEIDVTRAVLSQNRKAGQTSFKAAEQILKSMPVYQEGYALQKFHSQWEFWHVDTERKIQSGLFATEPELEQLIRLVAGDSEQWDAGIKESQDFYEYLPGYLLFTKPTCKPFELKIAAAKWLNRWCLLRPEREQCSMNRMVSQLMDHDLRLFIYDAQKLNDTHWFSTHLIDLIHHCGQLKSYFDQNNIDLPALRHSMIYEYGSYLMTSHNMWQLGIDYLDCCKQEGQAAIELLLPRITLRSERQATKLINLARQRGLISVEREICKVLSKRSYDNERYGNALEWAIRSKDVLLVTAVADFILKHYSKTGCMLCPDTIANVGGRMFASPRLVFLSKYFEFYEFYRTRDFLSASELLVNLLESKITPDYFWPSLLIDSMPLLESXDPKIFAKETVAILHHIETDLVPIIERDVSKYGKHHTETVFKDYRVENVDEIMNLLRLACARNLARALIIENTLPVV
Protein: Annexin A7 (Annexin VII) (Annexin-7) (Synexin) (P20072)
Organism: Bos taurus (Bovine)
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
Interaction partners:
- Annexin A11
- Sorcin
Sequence:
MSYPGYPPTGYPPFPGYPPTGQESSFPPPGQYPYPSGFPPMGGGAYPPAPSSGYPGAGGYPAPGGYPAPGGYPGAPQPGGAPSYPGGQGFGAPPGGAGFPGYPQPPTQSYGGGPAQVPLPGGFPGGAMPSQYPGGQSPYPSQPAPMTQGTHGTIRPAANFDAMRDAEVLRKAMKGFGTDEQAIIDVVANRSNDQRQKIKAAFKTMYGKDLIKDLKSELSGNMEELILALFMPSTYYDAWSLRNAMKGAGTQERVLIEILCTRTNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSMCQGNRDENQNVNHQLAQEDAQRLYQAGEGRLGTDESCFNMILATRSFPQLKATMEAYSRMANRDLLNSVSREFSGNVESGLKTILQCALNRPAFFAERLYYSMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFSQMYQKTLGTMIASDTSGDYRKLLLAIVGQ
Protein: DNA polymerase 1 (EC 2.7.7.7) (DNA polymerase I) (Pol B1) (P26811)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.
Interaction partners:
- DNA polymerase sliding clamp 2
- DNA polymerase sliding clamp 3
- DNA polymerase IV
- DNA polymerase sliding clamp 1
- DNA primase large subunit PriL
- Flap endonuclease 1
- DNA primase small subunit PriS
- DNA polymerase 3
- Minichromosome maintenance protein MCM
- DNA polymerase 2
Sequence:
MTKQLTLFDIPSSKPAKSEQNTQQSQQSAPVEEKKVVRREWLEEAQENKIYFLLQVDYDGKKGKAVCKLFDKETQKIYALYDNTGHKPYFLVDLEPDKVGKIPKIVRDPSFDHIETVSKIDPYTWNKFKLTKIVVRDPLAVRRLRNDVPKAYEAHIKYFNNYMYDIGLIPGMPYVVKNGKLESVYLSLDEKDVEEIKKAFADSDEMTRQMAVDWLPIFETEIPKIKRVAIDIEVYTPVKGRIPDSQKAEFPIISIALAGSDGLKKVLVLNRNDVNEGSVKLDGISVERFNTEYELLGRFFDILLEYPIVLTFNGDDFDLPYIYFRALKLGYFPEEIPIDVAGKDEAKYLAGLHIDLYKFFFNKAVRNYAFEGKYNEYNLDAVAKALLGTSKVKVDTLISFLDVEKLIEYNFRDAEITLQLTTFNNDLTMKLIVLFSRISRLGIEELTRTEISTWVKNLYYWEHRKRNWLIPLKEEILAKSSNIRTSALIKGKGYKGAVVIDPPAGIFFNITVLDFASLYPSIIRTWNLSYETVDIQQCKKPYEVKDETGEVLHIVCMDRPGITAVITGLLRDFRVKIYKKKAKNPNNSEEQKLLYDVVQRAMKVFINATYGVFGAETFPLYAPAVAESVTALGRYVITSTVKKAREEGLTVLYGDTDSLFLLNPPKNSLENIIKWVKTTFNLDLEVDKTYKFVAFSGLKKNYFGVYQDGKVDIKGMLVKKRNTPEFVKKVFNEVKELMISINSPNDVKEIKRKIVDVVKGSYEKLKNKGYNLDELAFKVMLSKPLDAYKKNTPQHVKAALQLRPFGVNVLPRDIIYYVKVRSKDGVKPVQLAKVTEIDAEKYLEALRSTFEQILRAFGVSWDEIAATMSIDSFFSYPSKGNS
Protein: Calumenin (Q6IAW5)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}. Melanosome {ECO:0000256|ARBA:ARBA00004223}. Sarcoplasmic reticulum lumen {ECO:0000256|ARBA:ARBA00004564}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF
Protein: STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) (Q9H2G2)
Organism: Homo sapiens (Human)
Function: Mediates apoptosis and actin stress fiber dissolution.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein kinase PLK1
- Cyclin-dependent kinase 1
- G2/mitotic-specific cyclin-B2
Sequence:
MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
Protein: Uncharacterized protein (Q586P8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYDEKVIVMCLFFFCCVCVCVCRGNIYAYIYIYIHFGGGACQEAIAVVLSYVAGVNDLHMTAPPLYISGVGFALVLRFIHFFLHYPSINTPHTFLYFTLLFFFSSTLFYPLTPLAYEKASRSTFCVSALLLYGCQGAVSEVFFFIYFKISVIVWSSQRPFLNFPIEKDSTSPSVYFLVCLFDCFFLIVEYTFVCDQMVMMGGAGVFVFWLVGTLSGCLKGCEGEEGGRGGRERKKKV
Protein: Autophagy-related protein 101 (Q9VWQ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Autophagy-related 1, isoform B
- Autophagy-related protein 13 homolog
- RB1-inducible coiled-coil protein 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Autophagy-related 14
- non-specific serine/threonine protein kinase
- Autophagy protein 12-like
- Raptor, isoform B
- Autophagy protein 5
- Ubiquitin-like-conjugating enzyme ATG3
Sequence:
MNARSQVFDLTMEGRQVDEAVATIFHTVLFHRCLGKYMYTGDAQYSIGTVGYTDVDCNFIDFTYVCCTSDSLTHKVKRAINSFSEKLRSNESCGSGQISLEFFQKKKNRWPFPQESIPWEVWTVHLDLIKHENEDERQLCRENVSDLLTEKVIYITELMNRHDYVPKTPSQSELDLIFDTSFPDVQPYLFKFDYSTSGSAAPSMGNAMKKIIKETLAM
Protein: Coiled-coil domain-containing protein 66 (F1PZQ5)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (By similarity). Plays a role in retina morphogenesis and/or homeostasis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:A2RUB6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:A2RUB6}. Cell projection, cilium {ECO:0000250|UniProtKB:A2RUB6}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A2RUB6}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A2RUB6}. Photoreceptor inner segment {ECO:0000269|PubMed:19777273}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:19777273}. Note=Restricted to the centrosomes and the spindle microtubules during mitosis (By similarity). Enriched in the inner segment of the photoreceptor (PubMed:19777273). {ECO:0000250|UniProtKB:A2RUB6, ECO:0000269|PubMed:19777273}.
Interaction partners:
- Photoreceptor disk component PRCD
- Centrosomal protein 72.
- Ring finger protein 123.
- 5'-3' exoribonuclease
Sequence:
MGSKNKIAKCPIRTKQTGYILKSTQNTCIRSGKLLQKKRMGSETSLAKGEKSSMIFSPTKDLCKQYVDKDCLYVQKEISPATPTIQKTRNTINTSVVAKQKHCKKHITAENTKSGLVCLTQDQLQQILMTVNQGNKSISAIENGKEETSQDSLHLNNTSNQPKDENIMGFQKNEALSSVLDENKSTLNKNQETSKQYEQKIAIENVWKPADIFSTLGERERDRSLLEAKKAQWKKELDEQVALKKKEKEASEKWNNPWKKFESDKIVWEKFQTLGQSKTSLSSSNILSQSPSQITVVQADDYPLCRASQILEETVPLERPLSTVKQEQQRKWIEDLNKQIEDDRQRKIEEKITSSKGEEHDRWAMHFDSLKNYPASQSQLSSRSIHNQPEYFCVSPDTQELSDISNVYTPTTGSQVEPSEEEHIAKPVRDMAMANSQKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEQQRKKEEQEEERRLAREREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSGLIKNLGGYGLDDVSGKMNTCINSTTSPKKDTAVQTDDLNTGMFTIAESCCGSIIEREILNCSSPEIPAEFNDQFKKDKQELINQDKAANLEKENSWYNDQYEFARTEKKHMKKCPKRPDWNINKPLKRYIPASEKYPKQLQKQREEKKVRRQMELLNLVERNNPGHLSQNRGTSPVLPSPQEAEARFRWHLIRKEEPLKSDSFSKKKKNRSQSPLELVKNRTQQTQTLKNRENLILGDSQTETSPGASEPSHFIPYVRTNEIYHLDPDAPLSRPLTQDLQYQNPHDCDQEQWQLFESDVRDPLLNPNLVKNRDRQQAILKGLSELRQGLLQKQRELETNLMPLAANQEENFNSSF
Protein: Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) (P31930)
Organism: Homo sapiens (Human)
Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07256}; Peripheral membrane protein {ECO:0000250|UniProtKB:P07256}; Matrix side {ECO:0000250|UniProtKB:P07256}.
Interaction partners:
- Cytochrome b-c1 complex subunit 9
- NADH dehydrogenase iron-sulfur protein 5
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- Cytochrome b-c1 complex subunit 10
- Cytochrome b-c1 complex subunit 6, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
Sequence:
MAASVVCRAATAGAQVLLRARRSPALLRTPALRSTATFAQALQFVPETQVSLLDNGLRVASEQSSQPTCTVGVWIDVGSRFETEKNNGAGYFLEHLAFKGTKNRPGSALEKEVESMGAHLNAYSTREHTAYYIKALSKDLPKAVELLGDIVQNCSLEDSQIEKERDVILREMQENDASMRDVVFNYLHATAFQGTPLAQAVEGPSENVRKLSRADLTEYLSTHYKAPRMVLAAAGGVEHQQLLDLAQKHLGGIPWTYAEDAVPTLTPCRFTGSEIRHRDDALPFAHVAIAVEGPGWASPDNVALQVANAIIGHYDCTYGGGVHLSSPLASGAVANKLCQSFQTFSICYAETGLLGAHFVCDRMKIDDMMFVLQGQWMRLCTSATESEVARGKNILRNALVSHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIAEVDASVVREICSKYIYDQCPAVAGYGPIEQLPDYNRIRSGMFWLRF