wanglab/gogpt-training-data huggingface dataset:
Protein: Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665] (Q9NQ38)
Organism: Homo sapiens (Human)
Function: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
Subcellular location: Secreted.
Interaction partners:
- Kallikrein-5
- Filaggrin
- Kallikrein-7
- Filaggrin-2
- Suppressor of tumorigenicity 14 protein
- Desmoglein-1
- Kallikrein-4
- Kallikrein-14
- PHD finger protein 11
- Corneodesmosin
Sequence:
MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFINKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGTTAASMPPSDE
Protein: Fez family zinc finger protein 2 (Forebrain embryonic zinc finger-like protein 2) (Foreheadin protein) (Zinc finger protein Fez-like) (Q804Q5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons.
Subcellular location: Nucleus {ECO:0000269|PubMed:11180958}.
Interaction partners:
- Iroquois homeobox protein 1, b.
- DNA-binding protein SATB
- T-box 1, brain
Sequence:
MASSLPLETVMSCPRLDDRSGATAAPKSLAFSIDRIMSKTSEPKAAAAEERSEGKKTVGLCSPIPCMIPIQPFSYDLQAKALMNYSEFWKVNFRGALCTSAAMCKTNCGVCSKADAGIKHSVLPGTRVIKPQVIHQALAMPANGSLCYFNYLDSAYQSELLSGHLFSSAIANSQAQAISAHQKLLLLENAKLACVSPEKFPTPQYPHKEHLPGQLDQIVRESHNLTEKNGVKAHSKTNNCSSDGKPKNFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTQEKPHKCNQCGKAFNRSSTLNTHIRIHAGYKPFVCEFCGKGFHQKGNYKNHKLTHSGEKQYKCSICSKAFHQIYNLTFHMHTHNDKKPFTCGTCGKGFCRNFDLKKHIRKLHDNANCLSGGNDSSRGHQN
Protein: C1GALT1-specific chaperone 1 (Core 1 beta1,3-galactosyltransferase 2) (C1Gal-T2) (C1GalT2) (Core 1 beta3-Gal-T2) (mC1Gal-T2) (Core 1 beta3-galactosyltransferase-specific molecular chaperone) (Q9JMG2)
Organism: Mus musculus (Mouse)
Function: Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
- Polypeptide N-acetylgalactosaminyltransferase 2
- Polypeptide N-acetylgalactosaminyltransferase 6
Sequence:
MLSESSSFLKGVMLGSIFCALITMLGHIRIGNRMHHHEHHHLQAPNKDDISKISEAERMELSKSFRVYCIVLVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWLMMRKAYKYAYDQYRDQYNWFFLARPTTFAVIENLKYFLLKKDQSQPFYLGHTVKSGDLEYVSVDGGIVLSIESMKRLNSLLSVPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLFIKEAMTNQPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHVFNDALVFLPPNGSEND
Protein: Geranyltranstransferase (EC 2.5.1.10) (Q5ZT35)
Organism: Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Interaction partners:
- Ditrans,polycis-undecaprenyl-diphosphate synthase
- Exodeoxyribonuclease 7 small subunit
- Squalene and phytoene synthases
- Isopentenyl-diphosphate delta-isomerase
- Octaprenyl diphosphate synthase IspB
- Mevalonate diphosphate decarboxylase
- Electron transfer flavoprotein-ubiquinone oxidoreductase
Sequence:
MVLIPTLNSTQMNKQVIDKYTQRHELYLEQLLNEIIIPAPQIRSALHYALFSGGKRIRPILVYLAGDLIDVDQGVLDIIAAALELTHCYSLIHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALAIEVLLMRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLDLSELAKSSVTEEQLREIHLLKTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRSSDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTKQLQNRSNLS
Protein: Thrombospondin 1 (F1SS26)
Organism: Sus scrofa (Pig)
Interaction partners:
- Leukocyte surface antigen CD47
- Platelet glycoprotein 4
- Matrix metalloproteinase-9
- Integrin beta
- Integrin alpha-V
- Integrin beta-1
- Uncharacterized protein.
- Syndecan
- Integrin subunit alpha 3
- Latent-transforming growth factor beta-binding protein 1
Sequence:
MGLAWGLSVLFLLHVCGSNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLAVERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQQVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSIFTRDLASIANLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTNVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTEENKELASELRRPPLCYHNGVQYRNNEEWTVDSCTECRCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSVTCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACQRDACPINGGWGPWSPWDICSVTCGGGVQRRSRLCNNPAPQFGGKDCVGDETENQICNKQDCPIDGCLSNPCFAGAKCTSYPDGSWKCGACPPGYSGNGIQCEDVDECKEVPDACFNHNGEHRCKNTDPGYNCLPCPPRFTGSQPFGRSVEYATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNEDLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDRDNCRLVPNPDQKDSDGDGRGDACKDDFDHDNVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRDS
Protein: Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Q9JIR4)
Organism: Rattus norvegicus (Rat)
Function: Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes.
Subcellular location: Cell membrane; Peripheral membrane protein. Synapse. Presynaptic cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Associated with plasma membranes from synaptic junctions. Not detected in synaptic vesicles. Detected in presynaptic nerve terminals close to the active zone. Detected in synaptic ribbons of ribbon synapses of retinal photoreceptor cells.
Interaction partners:
- Ras-related protein Rab-3A
- Protein unc-13 homolog B
- Protein unc-13 homolog A
- ELKS/Rab6-interacting/CAST family member 1
- Syntaxin-binding protein 1
- Syntaxin-1A
- Peripheral-type benzodiazepine receptor-associated protein 1
- Synapsin-1
- Complexin-1
- Synapsin-2
Sequence:
MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAESQPHQPPLNIFRCVCVPRKPSSEEGGPERDWRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAVSSQDTATPGAPLHRNKGAEPSQQALGPEQKQASRSRSEPPRERKKAPGLSEQNGKGGQKSERKRVPKSVVQPGEGIADERERKERRETRRLEKGRSQDYSDRPEKRDNGRVAEDQKQRKEEEYQTRYRSDPNLARYPVKAPPEEQQMRMHARVSRARHERRHSDVALPHTEAAAAAPAEATAGKRAPATARVSPPESPRARAAAAQPPTEHGPPPPRPAPGPAEPPEPRVPEPLRKQGRLDPGSAVLLRKAKREKAESMLRNDSLSSDQSESVRPSPPKPHRPKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKLLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQDEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIGVVPPVGYRASARESKATTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPADHRSRHVESQYSSEPDSELLMLPRAKRGRSAESLHMTSELQPSLDRARSASTNCLRPDTSLHSPERERHSRKSERCSIQKQSRKGTASDADRVLPPCLSRRGYATPRATDQPVVRGKYPTRSRSSEHSSVRTLCSMHHLAPGGSAPPSPLLLTRTHRQGSPTQSPPADTSFGSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKVKVHRFKQTTGSGSSQELDHEQYSKYNIHKDQYRSCDNASAKSSDSDVSDVSAISRASSTSRLSSTSFMSEQSERPRGRISSFTPKMQGRRMGTSGRAIIKSTSVSGEIYTLERNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRVGPDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLAPLTRRASQSSLESSSGPPCIRS
Protein: Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p25-alpha) (D3ZQL7)
Organism: Rattus norvegicus (Rat)
Function: Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (By similarity). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (By similarity). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (By similarity). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity). Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity).
Subcellular location: Golgi outpost {ECO:0000269|PubMed:31522887}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:31522887}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O94811}. Nucleus {ECO:0000250|UniProtKB:O94811}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:O94811}. Note=Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (PubMed:31522887). Mainly localizes to the cytoskeleton. Also found in the nucleus; however, nuclear localization is unclear and requires additional evidences. Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies. During mitosis, colocalizes with LIMK2 at the mitotic spindle (By similarity). {ECO:0000250|UniProtKB:O94811, ECO:0000269|PubMed:31522887}.
Interaction partners:
- Alpha-synuclein
Sequence:
MADSKAKPTKAANKTPPKSPGDPAKAAKRLSLESEGANEGAAAAPELSALEEAFRRFAVHGDTRATGKEMHGKNWSKLCKDCHVIDGKNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGRAPVISGVTKAVSSPTVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPGYKHAGTYDQKVQGGK
Protein: Cysteine desulfuration protein SufE (Q9EXP1)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Function: Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12876288}.
Interaction partners:
- Cysteine desulfurase
- SufD protein
- SufC protein
- SufB protein
Sequence:
MAQLPDPQKLLRNFSRCSNWEEKYLYIIELGAGLAPLSDAQRQDGNRVSGCQSQVWIDLASNEQGNVVLHGDSDAAIVKGLIAIVFSLYQGLSVREIVELDVRPFFASLALTQHLTPSRSQGLEAMLRAVRARASALI
Protein: Small ribosomal subunit protein bS16m (37S ribosomal protein S16, mitochondrial) (Q02608)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein uS13m
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein mS33
- Large ribosomal subunit protein uL16m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL22m
Sequence:
MTCGLVRIRLARFGRKNSPVYNIVVANSRKARDAKPIEVLGTYVPVPSPVTKRELKRGVVPIKDVKLDFDRTKYWIGVGAQPSETVTKLLRKAGILNDAWATSKNSNVNRKVVFERMETLE
Protein: Pregnancy specific beta-1-glycoprotein 16 (Pregnancy specific glycoprotein 16) (Q8K0U8)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MGQMYSGREIVSSNGSLWIHNVTRKDTGLYTLRTVNRRGEIVSTSFTFLYVYTSLFICGRPSFPAKLTIESVPPSVAEGGSVLLRVHNLQDKLRGLSWYKGAHVSRNLEIARQIIAKNSSVPGPAHSGRETVYSNGSLLLQNVTRNDTGFYTLQTLSRHRKMELAHVQLQVDTSLSSCCDTLDSTQLIIDPMPRYAAEGESILLRVLNLPEDFQVFCWYKGALIFQIFKIAEYSRARNSITKGPAQSRTERVYTNGSLLLQDVTEKDTGLYTLQTIDRNFKIEKAHVQIQVNKPVTQPFMRVTDSTVRVQSSVVFTCFSDNTGVSIHWLFNNQSLQLTERITLSPSKCQLRINPVRKEDGGEYQYEDHQRNPRLIGMQETTDTMGFPSPTDLSVP
Protein: Cyclin-dependent kinase B1-2 (CDKB1;2) (EC 2.7.11.22) (EC 2.7.11.23) (Q2V419)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with CDKB1-1, promotes both the last division in the stomatal cell lineage as well as the number of stomata. In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage.
Interaction partners:
- Cyclin-dependent kinases regulatory subunit 1
- Retinoblastoma-related protein 1
- Cyclin-A2-3
- Cyclin-dependent kinases regulatory subunit 2
- Cyclin-A1-1
- Cyclin-A2-4
- Putative cyclin-A3-1
- Cyclin-A2-1
- Cyclin-A2-2
- Cyclin-A3-4
Sequence:
MEKYEKLEKVGEGTYGKVYKAMEKTTGKLVALKKTRLEMDEEGIPPTALREISLLQMLSQSIYIVRLLCVEHVIQSKDSTVSHSPKSNLYLVFEYLDTDLKKFIDSHRKGSNPRPLEASLVQRFMFQLFKGVAHCHSHGVLHRDLKPQNLLLDKDKGILKIADLGLSRAFTVPLKAYTHEIVTLWYRAPEVLLGSTHYSTAVDIWSVGCIFAEMIRRQALFPGDSEFQQLLHIFRLLGTPTEQQWPGVMALRDWHVYPKWEPQDLSRAVPSLSPEGIDLLTQMLKYNPAERISAKAALDHPYFDSLDKSQF
Protein: Neurabin-2 (Q95Q64)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MTTASELLSDDARARFSHTKALFEQLERQQDVPSFYSPRLQRQPPPPLPPKPPSQCPPSPMSQVFSAFSVEDYDRKNEDIDPVASCAEYELERRLERMDLFEVDLEKGAEGLGVSIIGMGVGADSGLEKLGIFVKSITPGGAVHRDGRIRVCDQIVSVDGKSLVGVSQLYAANTLRSTSNRVTFTIGREQNLEESEVAQLIQQSLEHDRMRMMGDEEDDIEEPPPPPSQMPQLPIEQDRPTTSMITKEEIEIRSKIAALELELDVTHKKAEQYHEVLSSTKSHCDQLEKQNEQANYMIKNYQEREKELLNREENHVEQLRDKDVHYASLVRQLKERIDELESKLEEAEERRHSIQNLELIELREKLKEKVEKRNEGMAYRPGGELPHEDKAVMVNLETITPSTKKDAEVSVGSSWTEEYSSPCESPVPRISEPASPALPHKLTHRKLLFPLRKKYAENEFWRATCQPVGLQALHWTVDDVCQLLVSMGLDKYVPEFTINKIDGAKFLELDGNKLKAMGIQNHSDRSLIKKKVKGMKNKIERERKQLERESRTRVIAHTIPM
Protein: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (F2Z3U3)
Organism: Mus musculus (Mouse)
Interaction partners:
- Vasodilator-stimulated phosphoprotein
- Talin-1
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- Abl interactor 1
- Talin-2
- GTP-binding protein REM 1
- GTPase HRas
- GTPase KRas
- Filamin-B
Sequence:
MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDRLTQSLDSDKPKEPVKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQVTEPKVPQKLPAGRHTSKHGTLRGPSSSSNRTTKPSHANYSLDDITAQLEQASLSMDEAAQQSLVEDPKPLVTNQHRRTASAGTVSDAEARSISNSSRSSITSAASSMDSLDIDKVTRPQELDLTTHQGQPITEEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETISELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDCCLALKHPQIQKKSQYIKYLCCDDARTLHQWVNGIRIAKYGKQLYTNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTLPTGHIRSQSTVSSIFSEAWKRGTQLEESSKARMESMNRSYTSLMPPLSPQTKIITPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSSGSAATMFVKYSTITRLQNAAQHSGTLFKSPTPPAMQPLPLASQSKAQIVVPPNGVIPPPPPPPPPPTPGSAMAQLKPVPCAPSLPQFSPQPPPLKIHQVQHLPQTAPPTPPPAPPITATVPPQAPPKPLVTIPPSASTKTVSPVVAQAVPPTPAPPVPPAKKQPVFPVSHIPPTPPVQPTPHPPPTLPKQQSFGVKPPPSPLSPVPSVVKQIASQFPPPPTPPPVDSQPLKSLPASGTPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPPAPAPAPPPPPPPPPPPPPVPPTASPTPDKGGSPGKKTSKMSSPGGKKPPPTPQRNSSIKSGSCAEHPEPKRPSVDSLVSKFAPPAESGSPSKETPPPPAAPPKPGKLHLSGVNLPGIHQQGIVSAKASVLSGRGKDVVVEFPSPPSDSDFPPPPPEIELPLPPIEIPAVFSGNTSPKVAVVNPQPQLWSKTSVKKAPPPTRPKRNDSTRLTQADISEQPAMTTVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGFGGSHISGYATLRRGPPPAPPKRDQNTKLSRDW
Protein: Fibronectin type-III domain-containing protein (H2L0C1)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MGLRSRGLLLLSLGICYLQLFTLANVALNSNVRVKRQSGTDSLLTVEWEGIQTGDHADSEVKGFLVEYRPERSGEWQLHPGIIPYKGPNHQYRVQIPKLPTGISYLVRIKVIGENNEVLVETPEIRAHNEIVSIKCENDDLTAPRYPQVTEVAQYSLAIKWDAPDCGSVGDYQVELTGVSAPFDIHRQTVTQPHVSVTNLLPGTFYSVKVRAADRSRNVGPWNSEVLEAKTKGDALPISNNIQLLYRTDSELRVSWQPFTDPRLQHYEVTAVEVDDDSRRVERRRVDPALNSFALTGLRPNTKYTIGVIAFVDHEPKQVYQIEAYTTSGGIESWEEKPQVVDQGKQQFAVHWKLPTTSITVSKFILEYRLPNETTWRTSEQKGVADESGDYSVALSQMNAPYYTVRIVAIDDQNKVVARTEELTVGEAAETSCIGSAGVPTNIRSADVDGQSIKLEWDVPRCDETHTPIDGYEYIVYEASQSAPVDGASYVGAPHVIIKGLKQNVDYTFKVRSRSVNGHSQWSKDVIIETAVAGSVRSGELGEPNQLLRVKRQAKHLIKDSLNIFKLRIVLSPPCSFLVWTPLTQHSQIISKFKLMYKEVSSSKWIKLIGGMDHFRCPPGIADPEDYCYQLKGLFFGVHYISSISYKLTNGEELPSSNPLHFTLVQLDGSAAPSNERVTLTQPRIEQSASRSVAYWSVVGDRAAVTEYQVDIRSTDERSWRAVEPSVQNEQSQTHYRLPLGQLNVASTYLVRVRALDSSRATVATSPSASFSVLCQVPSAPENVRLERVSEQLVRAAWDSSQESGDCQSYFFITGQQNGQAINQRVPGSDRSVDIAGSSQGDWRVQVRGVNTAGSGTPSRDAIFASSAQQSRRSKRSVCDPRTDFWCKGEFSNSPLREPDSGEGAVSV
Protein: MIP18 family protein galla-1 (Q9V968)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos. The CGX complex is also required for cell proliferation in developing wing disks. In the CGX complex, acts with crb to recruit Xpd thus forming the functional complex.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:25065591}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25065591}. Note=Expressed in a punctate pattern in spindle microtubules during metaphase. {ECO:0000269|PubMed:25065591}.
Interaction partners:
- MMS19 nucleotide excision repair protein
- Probable cytosolic iron-sulfur protein assembly protein Ciao1
- General transcription and DNA repair factor IIH helicase subunit XPD
- Probable cytosolic Fe-S cluster assembly factor CG17683
- Anamorsin homolog
Sequence:
MLSYIKRKLSESDSGVSSVATVTSSCGGDSGRAGGTGSSESGTGSSSASISGRSQNADELVRKTSQMSMDDEAIAFGEDALLHELGYKNQTELQETIYDLLRGIRDPEKPCTLEDLNVVYEDGIFVMPPTRSNVSVVRIEFNPTVPHCSLATLIGLCIRVKVERGLPHNIKLDIYIKKGAHQTEEEINKQINDKERIAAAMENPNLRDLVENCIKDEE
Protein: Origin of replication complex subunit 5 (AtORC5) (Q6EWX0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O43913}.
Interaction partners:
- Origin of replication complex subunit 2
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM4
- Origin of replication complex subunit 1A
- Origin of replication complex subunit 4
- Origin of replication complex subunit 3
- Origin of replication complex subunit 6
- DNA replication licensing factor MCM3
- Origin of replication complex subunit 1B
Sequence:
MPPKEESSKVTRRSTRSSASVTVENSEPIESHTPTIDDLTFGEESITIDAVLSNFPGRRSQIFDFIRLMGPLDCPTLPIMIYGGASTGKTSVVLQVLRHLNRPFVYSSCRTCYNPRILFESILNQSLLHRKCSLNGYSSAKRCDKPSDFVNLLREALSSVIKTLESTSETSRSDKPDEKPMGKMVYLILDNVDLIRDWDKGTIILQFLFSLYTVLKMPQLGIILISGLPPDVYYSNMGYTDPIPLYFPEYSEEDLRQIFLRNQPNRKLYSAFLDVVLKPFCRVTRRVEELSTTFSLLFRKFCEPLDDLGISPNEDMKRRLYSHLKPLIAHCLNEIFRVSSHPHDGETRGERRQKASYSSENREELEILDFHMSTSAKFLLLSAFLASRNPATLDASMFDSTGGMDNRKRKRKASEKSMEKKEIAEQEAVMKGPGSFPLERLLAIFQCIASVGDSSFGEEDEEEENTTGYDKENNNLMSDILLQVSSLCDANFLIKSGSCPLEGSIRYRSMVSEDLAQKVAKSLSFPLSKYLYRR
Protein: Nucleolar and coiled-body phosphoprotein 1 (A0A0A0MRM9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XDAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKVWTITSVRAETVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSIKFDSE