wanglab/gogpt-training-data huggingface dataset:
Protein: Antimicrobial peptide 3 (Cn-AMP3) (P86707)
Organism: Cocos nucifera (Coconut palm)
Function: Has antimicrobial activity against Gram-positive bacteria B.subtilis (MIC=257 ug/ml) and S.aureus (MIC=274 ug/ml), and against Gram-negative bacteria E.coli (MIC=302 ug/ml) and P.aeruginosa (MIC=259 ug/ml).
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:19111587}.
Interaction partners:
Sequence:
YCSYTMEA
Protein: Cytochrome P450 monooxygenase vrtE (EC 1.-.-.-) (Viridicatumtoxin synthesis protein E) (D7PHZ6)
Organism: Penicillium aethiopicum
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system. The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA. The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB. The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone. The cyclization of the last ring could be mediated by the lactamase-like protein vrtG. The proposed post-PKS tailoring steps are an hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF. VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin. Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MFIAAVTHNWMERLAALSLLHYVLGAIFLLLLFHMLSNFFHPGLVDVPGPFAAKFTDLWRLFKVWQRRFKEDLPGLHASHRSTLIRIGPRMVSCSDPRAVELIYGFHTEFSKSDMVKAMAPIYKGKKQPTMFAAADNKTHARIRKPVAGAYAMTSIMQRMDELFIRPKRACDIHNWVQYFAFDMVLEMTMSRNLGFMKAGGDVDGVLKQLQKDLDYRGIALAMPIIDRIWRLNPVSKFFKPKQSGHFAMRCKRILEDRMAYEKSLDSRTQQQQDQKPHDFAHRFLEAQRKDPSISDGQLIGYMQANLIAGSDTTAVVMRTAIYYTLKQPWILQRLVTELDQYHGPLPVPFRIARFEMPFCGAIVREALRRHFAFIGMMERQTPPCGVVMPDGRRLPGGVVIGMHGDLIGRDRAIFGEDADEFNPLRWLARPGEPEAKYQERLRAMNAHDLAFGHGPRGCIGKHVAEMEIYKFIPTFFALIQPRFMRPEQSWTVRQLFVFKQSGMDMMLDWRQGKGLQSMA
Protein: Karyogamy meiotic segregation protein 1 (P87245)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in karyogamy, recombination and segregation during meiosis. Although it has been shown to associate with the spindle pole body it is unlikely to be involved in its formation or maintenance.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:10899136, ECO:0000269|PubMed:15654021, ECO:0000269|PubMed:16823372}. Note=Associates with the spindle pole body (SPB).
Interaction partners:
- Spindle pole body-associated protein sad1
- Telomere bouquet protein 1
- Telomere bouquet protein 2
- Dynein light chain Tctex-type
- Karyogamy meiotic segregation protein 2
- ADP,ATP carrier protein
- Dynein heavy chain, cytoplasmic
- DNA-binding protein rap1
- Bouquet formation protein 4
- Uncharacterized protein C2G2.14
Sequence:
MLNERDFDLIFDSYDFKHEGKVHLSNFLPIINDLQLLHPASAPPLLSEFQKQCTLEFVRQNADLSITKDNFRDVYKKLTENEDDSFANQAEKPSMEQQNSKNSIKEDANEHSVNSAHSKSSSNASPESLNPSQMMSKRLSLPPMSQFTDSDFVNILRTPFAQSTPLNRNTSSRNTEMPLVRKDKPDFSNGHHDLIKQITELQDMLDKARDQARKKSRTVDILEGKVNELTHQLNMADSKYNESKVANNSQNNQIKTLKAQNLNIHKNFQKIQSELIQTNSGLYSTKKELSALQVRYATLLRKFTDQTKKIEELSLAASRSSENENTIRRLALENHELKNSNNQLNNHIDDLTREKHLIALSNNPKGDEFLSPSNLDEMVYSKEVGLSFTQPSVCISIPAVGMRESEELRELEFKCKQQKKTIEECKHISQSLQSSLTAESSRNKELVAGFLMLSEEIGIQKWIIQSLSKMSPTLNDFCRRYDSSMPTYEESSHECTVLSSFSDDETGLMATNTTMNNSSKDFMASQDTVNADNPHFLATKGQPLLLLSVMKSNILRLFYVLFLFACFYGLDYILCAELLQAFLRVVFTFCEHIIILLYGRYELVQPS
Protein: oryzin (EC 3.4.21.63) (Q4WQI8)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- Pheromone-processing carboxypeptidase kex1
- Neutral protease 2
- Neutral protease 2 homolog AFUB_070680
- Neutral protease 2 homolog AFUA_4G13750
- Extracellular metalloprotease AFUA_1G07730
Sequence:
MRFLGSIALVLSSISVASANVRSRSYDTHEFFALHLDDSASPSHVAQLLGARHEGQIGELANHHTFSIPRERSSDLDALLERARAARKIRRRARDDATSQEQHNDALGGILWSQKLAPKKRLVKRVPPPERLARTFATGKEDPVAAQSQKRIASTLGITDPIFNGQWHLFNTVQLGHDLNVTGVWMEGITGKGVTTAVVDDGLDMYSNDLKPNYFPEGSYDFNDHTPEPRPRLSDDKHGTRCAGEIAAARNDVCGVGVAYDSRVAGVRILSKAIDDADEATAINFAYQENDIFSCSWGPPDDGATMEGPGILIKRAFVNGVQNGRGGKGSIFVFAAGNGASFEDNCNFDGYTNSIYSITVGAIDREGNHPSYSESCSAQLVVAYSSGSGDAIHTTDVGTDKCYSFHGGTSAAGPLAAGTVALALSARPELTWRDAQYLMVETAVPIHEDDGSWQVTKAGRKFSHDWGYGKVDAYALVQKAKTWELVKPQAWFHSPWLRVQHKVPQGDQGLASSYEVTEQMMKNANIARLEHVTVTMNVNHTRRGDLSVELRSPEGIVSHLSTTRKSDNEKAGYVDWTFMTVAHWGESGVGRWTVIVKDTNVNEFTGEFIDWRLNLWGEAIDGANQKPHPFPDEHDDDHSIEDAIVATTSVETGPTKTGVPGSTDDTINRPVNAKPVETQTPSPAETTATKLAPPAETRPAATATSSPTPPAASDSFLPSFMPTFGASKRTQIWIYAAIGSIIVFCIGLGIYFQVQRRKRILNNPRDDYDFEMIEDENALHGGNGRSGRTQRRGGELYNAFAGESDEEEPLFSDEDDEPYRDRAPSEDRLRDTSSDDRSLRHGDH
Protein: Parkin coregulated gene protein (A5PK71)
Organism: Bos taurus (Bovine)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37327785}.
Interaction partners:
- Outer dynein arm-docking complex subunit 2
- EF-hand domain-containing family member C2
- EF-hand domain-containing protein 1
- RIB43A-like with coiled-coils protein 2
- Outer dynein arm-docking complex subunit 3
- Cilia- and flagella-associated protein 52
- Tektin-2
- Meiosis expressed gene 1 protein homolog
- WD_REPEATS_REGION domain-containing protein.
- Tektin-3
Sequence:
MVAEKETLSLNKCPAKLPTRTKLLAQQPLPVHQPHSLVSEGFTVKAMMKNSVVRGPPSAGAFKERPTKPTAFRKFYERGDFPIALEHDSKGNKIAWKVEIEKLDYHHYLPLFFDGLCEMTFPYEFFARQGIHDMLEHGGNKILPVIPQLIIPIKNALNLRNRQVICVTLKVLQHLVVSAEMVGEALVPYYRQILPILNIFKNKNVNSGDGIDYSQQKRENIGDLIQETLEAFERYGGEDAFINIKYMVPTYESCLLN
Protein: LD10135p (Q9VK43)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDTKSNDDSAGSDSLDKSMQIKCVMVETTTTGDGDSTVGDLDNCSRDSAAESINKESGSMEGAGKQTDHKTEAAAGSCGEGDSPQSSQSPPEHPASKSPTSPCTAFETKVKLISQNLKETTLAESTGASVSASTSTSTPTSASSSISGSMLESQQTPSQSTPETTDSASSSVRVKKVRFHPDVKENDGGNWMKRKRRSMHTKRTSSPSGANCDGMELDGEYEDNDDDEQEEAEEEFDLAKTIAEAEDYLKQHPLTYVQRVEQNGERLQDGLLSIEDMLNEVGEEVVTEYNDEDFFRRIKPENGIERILGKETKAGKVEFLLRYENQGGLFWQSEEFIKRTCPSLLKAYEMNRERRQQRLMHHVAKRQSLRQRYTDF
Protein: SKP1-like protein 13 (AtSK13) (Q9M1X5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Cullin-1
- Cullin-2
- Cullin-like protein 3
- Putative cullin-like protein 2
- Putative cullin-like protein 1
- RING-box protein 1a
- RING-box protein 1b
- F-box protein 7
- F-box protein SKIP22
- Elongin-C
Sequence:
MSKMVMLLSSDGESFQVEEAVAVQSQTIAHMIEDDCVANGVPIANVTGVILSKVIEYCKKHVVSDSPTEESKDELKKWDAEFMKALEQSSTLFDVMLAANYLNIKDLLDLGCQTVADMITGKKPDEIRALLGIENDFTPEEEEEIRKENQWAFE
Protein: 4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase) (Q8I7J4)
Organism: Caenorhabditis elegans
Function: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03189}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03189}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03189}.
Interaction partners:
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- All trans-polyprenyl-diphosphate synthase PDSS1
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Ubiquinone biosynthesis protein coq-4, mitochondrial
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Atypical kinase coq-8, mitochondrial
- isopentenyl-diphosphate Delta-isomerase
- Phosphatidate cytidylyltransferase
- Farnesyl pyrophosphate synthase
- FAD-binding domain-containing protein
Sequence:
MITRSIGIARRSNSINCIVGSNTSTSYSLDESTKRWISTSTKQPMSLIPTASSLVASSPPNLKPYLQLMRVDKPIGTWLLYWPCTWSIAMATPAGQLPSIYMLSLFGAGAFLMRSAGCVINDLWDKDFDKKVERTKLRPLACGSLTEKQAIGLLAGLLSSSLAILLQLNWYSVAVGASSMALVVGYPLAKRFTYWPQFVLGLTFNWGALLGWCALKGDLSSSAPFWMYAAALQWTLIYDTIYAHQDKADDIMIGVKSTALRLGADTKKWLSAFGVGTVASLTACGIASDQTWPYYVALAATTAQLGWQVGTVDIDNGSDCWDKFKSNSWMGIILFSGIVASTLLKEVFQILIRPYH
Protein: Aristaless-related homeobox protein (ARX) (O42115)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor (By similarity). Appears to be indispensable for the central nervous system development. May have a role in the neuronal differentiation of the ganglionic eminence and ventral thalamus. May also be involved in axonal guidance in the floor plate.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
Interaction partners:
Sequence:
MSSQYDDDSRDRSECKSKSPTVLSSYCIDSILGRRSPCKVRQLGAQSLPAPVRPDHEMTTEVTSKENSFDSDMHLPPKLRRLYGPGGKYLDSGRGFHEHLEKGERERLLDQACESLKISQAPQVSISRSKSYRENAPFSQSDEGQSPEHMAQELVELSTLKFEEDVVKEEACGDNSLSPKDEESLHNDGDVKDGEDSVCLSAGSDSEEGMLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGVQAHPTGLPFPGPLAAAHPLSHYLEGGPFPPHPHPALESAWTAAAAAAAAFPGLAPPPNSSALPPATPLGLGTFLGTAMFRHPAFIGPTFGRLFSSMGPLTSASTAAALLRQTAPPVESPVQPSAALPEPPSSSSSTAADRRASSIAALRLKAKEHSAQLTQLNILPSGTAGKEVC
Protein: Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein (Q2UE59)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Interaction partners:
- pyridoxal kinase
- glutaminase
- pyridoxal 5'-phosphate synthase
- NADP-dependent oxidoreductase domain-containing protein
- pyridoxine 4-dehydrogenase
- NADP-dependent oxidoreductase domain-containing protein
- pyridoxal 5'-phosphate synthase
- NADP-dependent oxidoreductase domain-containing protein
- 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
Sequence:
MAPQAPWRSLFQSHLTQNSSTSFTLSTVDHDSQNRPVPRSRTCEFRGFWPSPQLHDKAVEALNSQGIGQNPAVYESDMISLTTDVRMEKVGQLDSSANVVEGIFWLTDVGNQWRVKGEAFVIGDPKGGAHEEAARKEIQTGMNVTGKDADVSEWTWERQVTAYFANHSPVMRGSFKNPSPGQPRTQEPADPNLKLGQKVDDLQDSIARGNFRVVVIRPNEVERLDLSDLQNVRRVRWTFVPADNTGGQGEWVETELWP
Protein: Actin-like protein 2, putative (Q387T4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Actin-like protein 3, putative
- Arp2/3 complex 34 kDa subunit
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5
- Arp2/3 complex 41 kDa subunit
- ARP2/3 complex subunit, putative
- Actin, putative
- WASH1 WAHD domain-containing protein
- BTB domain-containing protein
- ADF-H domain-containing protein
Sequence:
MSEKLPVVLDNGSGFLKCGFAGSNFPEVFFRTAVGRPVLRQTKVSEGRSSKRKDTQVDPLTKDLVLGDECNGAHHLLDMTFPIHNGVIQNMDDMRYLWKHAFHNLLSIEPEDHSLLISEAPLFSHKDRVKLYEVMFEEFKFPFVQSTPQGVLSLFSNGLQTGVAVECGECVSHCTPIFEGYTIPKANRRVDLGGRNITEFLVRLMQRRGYSFNQSSDFETVRCIKERFCYAAVDPKLEQRLALETTVLEKTFLLPDGSSCSIGQERFEATEALFQPRLIDVECEGISSQLWNCIQATDIDVRFALYSHVVLSGGSTMFPGFPSRIERDMRAAYSERIVKGDPERLSRFPLCVEDPPRRRWMSFLGGAALAAVTAGNHDMWLSKKEWDEGGASAIQARFGV
Protein: Mediator of RNA polymerase II transcription subunit 4 (Mediator complex subunit 4) (RNA polymerase II mediator complex protein pmc4) (Q9Y821)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 19
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 8
Sequence:
MEYQRAIDSIEECLNKQLRLSSEKVDQYVLIENWTSLVGHLKTLHSLISNYTNGRELQNEISSLLKQDKELDLQIQDCMREMTSIYDTHLPKTVSGRKRQKVNAETLLDYGRKLSKFSSAPPGYNPETGQDAKAPVHYPWPSEDQMRKTLLFQFSTSMVPNLSATASQLFSEQPPKTNEPTETETEIDANKAVEEKTKMNYPASPTFTTQEENKEVESPANKDVFAGFDLFDPEMEEDF
Protein: Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66) (Q96BY9)
Organism: Homo sapiens (Human)
Function: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22464749}; Single-pass type I membrane protein {ECO:0000269|PubMed:22464749}. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Interaction partners:
- Stromal interaction molecule 1
- Short transient receptor potential channel 1
- Store-operated calcium entry regulator STIMATE
- Calcium release-activated calcium channel protein 1
- EF-hand calcium-binding domain-containing protein 4B
- Solute carrier family 35 member G1
- EF-hand domain-containing family member B
Sequence:
MAAACGPGAAGYCLLLGLHLFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDPIPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTKTRTASGYGGTRRR
Protein: Glycosyl hydrolase family 13 catalytic domain-containing protein (O45298)
Organism: Caenorhabditis elegans
Interaction partners:
- Large neutral amino acids transporter small subunit 1
- Amino Acid Transporter
- Large neutral amino acids transporter small subunit 1
- 1,4-alpha-glucan branching enzyme
- Alpha-1,4 glucan phosphorylase
- Amino acid transporter
- phosphoglucomutase
- Bifunctional glyoxylate cycle protein
- Probable acyl-CoA dehydrogenase 6
- Serpentine receptor class epsilon-13
Sequence:
MDATDRLMPGPEGKTPRFYEVDRGNKTESYISAVSGNPVVPEHIMRKEKRQEQEEAPPQKSWERPPAPTNPKNTDQIGLSEQELEQFRNDPCWKFIRTVLFVLFWLIWLALFAVAILLVCFSPTCVLRAKPNWWQTAVAYHVWVPSFQDSDGDGVGDVDGLINRLDQLRKSGVQTVWPSPFLISDDEKTAVRSFSQMDPKIGVNQKADELINKIHEKEMNIVISFPIATTSLEHEWFLNSATASKTPNANYSQFYTWVSKAADSNFFTEHKNLFYLHEKGNPKSAVLNWQNSNLREHMFNALSNWIDRGVDGFELQGIEYLARTPNGTEPDWNSIYDVIRDIRFHVDSYSNESTIADGKKIALFSTREEAKEKDKKRMAKSGMDTVINYELGEVEKDTKICHKNEGSVATCVHEILSDVLLFHSLNEQVWPHWRFGSPDLARIASRVGSRPHAQLLMVLQMILPGTNNIYYGEEIGMRNLANDSRVPPQKGAMQWDDSLNGGFTSAISPPVPSNIDVANINWKRQYAEPQSTLKIFAKLAKLRQREDALMTGTTLIGRLVDGAFTITRFNNFENRTTGNIYVAALNFAEHPVKLPLTDLPSNSKLHKSTIVTATSNCVAYYARQTVDFGLKEIELEPNEGVVFRYSA
Protein: Meiotically up-regulated gene 133 protein (Q10240)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:16823372}. Vacuole membrane {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotically up-regulated gene 112 protein
- Meiotic fizzy-related protein 2
- Serine/threonine-protein kinase ppk33
- Meiotically up-regulated gene 8 protein
- Meiotically up-regulated gene 24 protein
Sequence:
MEECKLDINKGKDAEILYEEYKYHEIKEMSFSSCARTSPELLKKFGCDAHVITSVEGAPKKENKKIWEFFKGSNKIKNLFTMFTCCFANDEEEIWGEETNESVVYKEYTYNSRWKIEIPSYPVREIPYVVADTPYNKLLCPLSSLEWVSKLILMDNANSIGMKNNRYSTNPFIYGMCYIIRNNANRILLESCYCENSTGMSTCPRILEFMPYEPLLKYNSYRLLSTYENSYKELSEMLTNNNAPLEVLIHHVMLYHYYPSFLQSALWTAVSSYLEERCNNGLYSKLLVKAAKQHFGDIRLYFVTPDDIYTFDHCNNWIAIVTRNFMAYIETKRKLEFDSIPFNCPLITQLFPLISSPKEMAWLLLIVCTDSNESWFPVHAYINTKTRILRPRSPKLDFFLKESDLLYFQDKQSISEFDIIRKDLLEDLIQCDSYVNTREQLRRRRETLNRKRITIAKLQNNHSQITFPYKRHNIHKSVDSIQFCKPASNLLTLKDNSYTQIPLEPLLLAEISV
Protein: Transcriptional regulator Rv0485 (P9WKV1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Positively regulates the expression of PE13 and PPE18. Can also regulate expression of some other genes. Plays a role in modulation of innate immune responses.
Interaction partners:
- Uncharacterized oxidoreductase Rv0484c
- D-inositol 3-phosphate glycosyltransferase
- Uncharacterized protein Rv0487
Sequence:
MYSTNRTSQSLSRKPGRKHQLRSHRYVMPPSLHLSDSAAASVFRAVRLRGPVGRDVIAGSTSLSIATVNRQVIALLEAGLLRERADLAVSGAIGRPRVPVEVNHEPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTPRNAAGAALTSLADSADRYLQRWRRRRALWVGVTLGGAVDSATGHVDHPRLGWRQAPVGPVLADALGLPVSVASHVDAMAGAELMLGMRRFAPSSSTSLYVYARETVGYALMIGGRVHCPASGPGTIAPLPVHSEMLGGTGQLESTVSDEAVLAAARRLRIIPGIASRTRTGGSATAITDLLRVARAGNQQAKELLAERARVLGGAVALLRDLLNPDEVVVGGQAFTEYPEAMEQVEAAFTAGSVLAPRDIRVTVFGNRVQEAGAGIVSLSGLYADPLGALRRSGALDARLQDTAPEALA
Protein: Myosin light chain 4 (Myosin light chain 1, embryonic muscle/atrial isoform) (Myosin light chain alkali GT-1 isoform) (P12829)
Organism: Homo sapiens (Human)
Function: Regulatory light chain of myosin. Does not bind calcium.
Interaction partners:
- Myosin-7
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin-6
- Myosin light chain 3
- Actin, alpha cardiac muscle 1
- Myosin light chain kinase 2, skeletal/cardiac muscle
- Myosin light chain kinase family member 4
- Myosin light chain kinase 3
- Myosin light chain kinase, smooth muscle
- Myosin regulatory light chain 11
Sequence:
MAPKKPEPKKEAAKPAPAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMSG
Protein: Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) (Q54X55)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- ATP-dependent DNA helicase ku70
- poly
- Exonuclease 1
- DNA-dependent protein kinase catalytic subunit
- X-ray repair cross-complementing protein 5
Sequence:
MEKEKFTSHEGLRQTVEYSKSARSSCKKCKGTIGMDTIRVGTETPSRVFDGYDVKYYHLSCMDFPKLKIFYINQLKHYELLRWDDQLKIRKILGQTDDGLNLALSTYYNEVWRIKDILISELKPAIIKKLFLEFYPKLDSLSPSYYLHFLADGLSYGRIGPCPSCNGLTVLYDGKNYYCRGFSSSFSRCTWHGQEVKRYRFIIPKELMPKTSFFKGYTFSQIHPYEVLEYKETEGINSTKETEIPTFSALSISDSKDNGSNNNNNNNNDDDNNSFFYKKSPIKKNSTLLKVDPSFSNANKGEILVLEDDVYGYVAYNVLMNLTDLIHNNNSYYILQIIKTGDTSYWVYCKWGRIGVSNGGTMQHSHTSLNKALKEFGERFTDKTGIEWNDRGKYKKQNGKYAIIDLEENVGEFSSGGDNEVEAPIVAPVNTKPSKLLQPVQSLVNTLFDSELMKKSLTSLQFDVQKMPLGKLSQNQINKAYEVLNRIQELLETIEKQSPLQPLSPTAQHNIKSEIMAESSKFYTHIPHRFEGGLMSKIPPIDNKELLVKCIRLVDALSEIEVVNQLKRLSTSTSGNSTDDNYNLLKADIKPLERDSFLFRNIEEFALSTVDPSLGYSIDVLDVFKVDRIGDDQFSQWESNHNRMLLFHGSRIQSWCSILPNGLKIASPLSPKSGYRLGKGVYLADCISLSGLYTGATKENPTAIIAICDVALGNSAALYHDTYMEEPQLGYLSTKALGKRQPALYDQLNGCYQDKDEFIPSSVLKGPIIETGSIVTFFTPNEYVIYNNSQCRIKYLLKLRLNFD
Protein: Galactan endo-beta-1,3-galactanase (EC 3.2.1.181) (Endo-beta-1,3-galactanase) (FvEN3GAL) (F7J1C8)
Organism: Flammulina velutipes (Agaricus velutipes)
Function: Specifically hydrolyzes beta-1,3-galactan in an endo-fashion. Requires at least 3 contiguous beta-1,3-residues.
Interaction partners:
Sequence:
MKLFVVLACLAAPGTFPFVDAATVIPANSFSSFSTYWNNFYPWGTDHNGSGRMASANIIVASNTLSLIATPTSNPSPPTSTSNPKPAIHYASGAIHAKEHITVTAANAYTVSGEFSAPTAVGTWPAFWLTAVSGWPPEVDIGEWKGTADNWFNTFNTSSVVKSTLVDWPTDLSFHSVKAVLTAQSNNKDVKIDFYMDNKFIVTQYGSGFVGKAMYLIINLQMEGSSGSPGPSGRTVYKARNVQVTRTGN
Protein: Pancreatic polypeptide prohormone [Cleaved into: Pancreatic polypeptide (PP); C-terminal peptide] (P10601)
Organism: Mus musculus (Mouse)
Function: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01298}.
Interaction partners:
- Peptide YY
- Pro-neuropeptide Y
- Somatostatin
- Pro-glucagon
- Appetite-regulating hormone
- Insulin-1
- Insulin-2
- Neuropeptide Y receptor type 2
- Neuropeptide Y receptor type 4
- Neuropeptide Y receptor type 1
Sequence:
MAVAYCCLSLFLVSTWVALLLQPLQGTWGAPLEPMYPGDYATPEQMAQYETQLRRYINTLTRPRYGKRAEEENTGGLPGVQLSPCTSPPVGLIPCSAPWS
Protein: AT4g36960/C7A10_400 (RNA-binding (RRM/RBD/RNP motifs) family protein) (Q94AC3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- RING/FYVE/PHD zinc finger superfamily protein
- Probable receptor-like protein kinase At1g49730
- Putative BPI/LBP family protein At3g20270
- Amino acid transporter AVT3A
- Peptidyl-prolyl cis-trans isomerase CYP57
- Protein DEHYDRATION-INDUCED 19 homolog 5
Sequence:
MERKLVVLGIPWDIDSDGLKDYMSKFGDLEDCIVMKDRSTGRSRGFGYVTFASAEDAKNALKGEHFLGNRILEVKVATPKEEMRQPAKKVTRIFVARIPSSVSESDFRSHFERYGEITDLYMPKDYNSKQHRGIGFITFSSADSVEDLMEDTHDLGGTTVAVDRATPKEDDHPPRPPPVARMSRPPVAIAGGFGAPGGYGAYDAYISAATRYAALGAPTLYDNPATFYGRGEPTTRGIGNKIFVGRLPQEASVDDLRDYFGRFGHIQDAYIPKDPKRSGHRGFGFVTFAENGVADRVARRSHEICGQEVAIDSATPLDEAGPSAGASSMLSSSRPEYFGGYGGPMRAFGRMYGGMSLDDWGYGMPNARPSRPDRRYRPY
Protein: SH2 domain-containing protein 4A (Q9D7V1)
Organism: Mus musculus (Mouse)
Function: Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation (By similarity). May play a role in T-cell development and function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17251388}. Note=Located at podocyte foot processes.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Sequence:
MLRQILSDMFIDPDLLAELSEEQKQILFYKMREEQIRRWKEREAAMERKESLPVKSRPKKENGKSVHWKLGADKQVWVWVMGEHHLDKPYDVLCDEILAEREHLRAAKDSELRKTQSLELANSLKIKSQNCDLQAMKKTEPQNVTRKAASEEASGQGPRAIPTRKDDKAQTKPVKEKDHEEMKQTEDEKTKQIYKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGDGLQNPLTGPQKPRRPPLPPKPQFLQPLGIPPKSLGNQGVIRTEISSAQMDTIRWFKEEQLPFRAGYQKNSDTIAPWFHGILTLKKANELLSTGVPGSFLIRVSEKIKGYALSYLSEEGCKHFLIDASANSYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDKLPDYLELFQ