Protein: Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Chick receptor tyrosine phosphatase alpha) (CRYP alpha) (CRYPalpha) (F1NWE3)
Organism: Gallus gallus (Chicken)
Function: Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:17178832, ECO:0000305|PubMed:17967490}; Single-pass type I membrane protein {ECO:0000305|PubMed:17967490}. Cell projection, axon {ECO:0000269|PubMed:7600997}. Perikaryon {ECO:0000250|UniProtKB:B0V2N1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q64605}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q64605}. Postsynaptic density {ECO:0000250|UniProtKB:Q64605}. Cell projection, neuron projection {ECO:0000250|UniProtKB:B0V2N1}. Cell projection, growth cone {ECO:0000250|UniProtKB:B0V2N1}. Note=Detected along neurites and at axon growth cones. {ECO:0000269|PubMed:7600997}.
Interaction partners:
- NT-3 growth factor receptor
- Interleukin 1 receptor accessory protein like 1.
- SLIT and NTRK like family member 1
- SLIT and NTRK like family member 3.
- Agrin
- SLIT and NTRK like family member 2
- Caskin-2
- Interleukin 1 receptor accessory protein.
Sequence:
MRILPSPGMPALLSLVSLLSVLLMGCVAESPPVFIKKPVDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENIYECVAQNPHGEVTVHAKLTVLREDQLPPGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSTSNGRIKQLRSGGLQIESSEETDQGKYECVASNSAGVRYSSPANLYVRELREVRRVAPRFSILPVSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPVVTETTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQGRMLSSTTMIIQWEEPVEPNGQIRGYRVYYTMEPDQPVSNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNFRAEAKTETSIVLSWSPPRQEIIVKYELLFKEGDHGREVPRNFEPTTSFTVEGLKPNTEYVFRLAARSALGLGAFTPEVRERTLQSILPKNFKVKMVTKTSVLLSWEFPENYNSPTPYKIQYNGLNVDVDGRTTKKLITNLKPHTFYNFVLMNRGNSMGGLQQNVAAWTAANMLSRKPEVTHKPDADGNVVVILPDVKSSVAVQAYYIVVVPLRKSRGGQFLNPLGSPEEMDLEELIQDIARLRRRSLRHSRQLDFPKPYIAARFRSLPNHFVLGDMKHYDNFENRALEPGQRYVIFILAVLQEPEATFAASPFSDPIQLDNPDPQPIIDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKRKDSEPRTKCLLNNAEITPHHPKDPVEMRRINFQTPDSGLSSPLSDPEFDFESMLSHPPIPVSELAEHTEHLKANDNLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILLPIEGIVGSDYINANYIDGYRKQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTKLEEKSRIKCDQYWPGRGTDTYGMIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEAVACGNTEVPARNLYTYIQKLAQIEVGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYETTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT