wanglab/gogpt-training-data huggingface dataset:
Protein: Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (P32182)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis (By similarity). Involved in regulation of fat metabolism. Acts synergistically with ONECUT1 to activate transcription of female-specific CYP2C12; the function is inhibited by growth hormone-activated STAT5B. Acts synergistically with HNF4A to activate transcription of APOA1.
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
Interaction partners:
- Ribosomal protein S6 kinase beta-1
- Ribosomal protein S6 kinase
- SRY-box transcription factor 17
- Pancreas/duodenum homeobox protein 1
- Hepatocyte nuclear factor 6
- Transcription factor GATA-4
- Homeobox protein OTX2
- Paired box protein Pax-6
- Androgen receptor
- Homeobox protein NANOG
Sequence:
MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNASLGMNGMNTYMSMSAAAMGSGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMSGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDFLKVPRAPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCENELALKEAAGAGSGGGKKTAPGTQASQVQLGEAAGSASETPAGTESPHSSASPCQEHKRGGLSELKGTPASALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKTYEQVMHYPGGYGSPMPGSLAMGPVTNKAGLDASPLAADTSYYQGVYSRPIMNSS
Protein: Signal peptidase complex catalytic subunit SEC11 (EC 3.4.21.89) (O97066)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648}.
Interaction partners:
- Signal peptidase complex subunit 2
- Signal peptidase complex subunit 1
- Signal peptidase complex subunit 3
- DNA-directed RNA polymerase II subunit RPB7
- Exosome complex component RRP40
- Translocon-associated protein subunit gamma
- Probable peptidyl-tRNA hydrolase 2
- Protein transport protein Sec61 subunit beta
- Translocon-associated protein subunit delta
- Translocon-associated protein subunit beta
Sequence:
MGVASMLQIDEMLGDFNRMNKRQSLYQVLSFAMIVSSALMIWKGLMVVTGSESPIVVVLSGSMEPAFHRGDLLFLTNYKEEPVRVGEIVVFKVEGRDIPIVHRVIKLHEKEDGSVKFLTKGDNNNVDDRGLYAPNQLWLTKKDIVGRARGFLPYVGIITIFMNEYPKVKWAILSILAIFVLLHRE
Protein: Xylose isomerase (EC 5.3.1.5) (D-xylulose keto-isomerase) (P00944)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm.
Interaction partners:
- Xylulose kinase
- D-xylose-binding periplasmic protein
- Xylose operon regulatory protein
- PTS system fructose-specific EIIB'BC component
- L-arabinose isomerase
- D-xylose-proton symporter
- Ribulokinase
- Fructokinase
- Glucokinase
- Beta-galactosidase
Sequence:
MQAYFDQLDRVRYEGSKSSNPLAFRHYNPDELVLGKRMEEHLRFAACYWHTFCWNGADMFGVGAFNRPWQQPGEALALAKRKADVAFEFFHKLHVPFYCFHDVDVSPEGASLKEYINNFAQMVDVLAGKQEESGVKLLWGTANCFTNPRYGAGAATNPDPEVFSWAATQVVTAMEATHKLGGENYVLWGGREGYETLLNTDLRQEREQLGRFMQMVVEHKHKIGFQGTLLIEPKPQEPTKHQYDYDAATVYGFLKQFGLEKEIKLNIEANHATLAGHSFHHEIATAIALGLFGSVDANRGDAQLGWDTDQFPNSVEENALVMYEILKAGGFTTGGLNFDAKVRRQSTDKYDLFYGHIGAMDTMALALKIAARMIEDGELDKRIAQRYSGWNSELGQQILKGQMSLADLAKYAQEHHLSPVHQSGRQEQLENLVNHYLFDK
Protein: alpha-1,2-Mannosidase (EC 3.2.1.-) (Q5ZK76)
Organism: Gallus gallus (Chicken)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
- SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.
- alpha-1,2-Mannosidase
- alpha-1,2-Mannosidase
- BZIP domain-containing protein.
- DnaJ heat shock protein family
- Activating transcription factor 6.
- Uncharacterized protein.
- DnaJ homolog subfamily B member 9
- Endoplasmic reticulum chaperone BiP
- Uncharacterized protein.
Sequence:
MQWRSLVLGLLLLRLGLHALLALLPALAPGLCLRLRLPFPFPPRSAALGPPGAARPLPGGGSSHWGSLRGGGGAAGRDEYETRYSAAFPPQLRARLRDAARGMFAFGYDSYMQHAFPSDELDPLHCCGRGPDRDDPSNLNINDVLGNYSLTLIDALDTLAVMGNSSEFQKAVKLVIDTVSFDKDSTVQVFEATIRVLGSLLSAHIIITDAKQPFGDMTIKDYDNELLHMAHDLAVRLLPAFENTKTGIPYPRVNLKKGVPPNSNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWSLRSNNTGLLGNVVNIQTGHWVGKQSGLGAGSDSFYEYLLKSYILFGEKEDLEMFIDAYQNIQNHLRRGREACNEGEGDPPLYVNVNMFTGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYNWQLQAPDVPFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKAKCGYATLHHVVEKTKEDRMESFFLSETCKYLYLLFDEDNPVHKSGNKYMFTTEGHIVSVDERFRNSLWQDILPGEEGTEKVKPNELKAVNFSSNCNRVPDERRYLLPLKSNYMRQIDRMVGLI
Protein: MYG1 exonuclease (EC 3.1.-.-) (Protein Gamm1) (Q9JK81)
Organism: Mus musculus (Mouse)
Function: 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:19014353, ECO:0000269|PubMed:31081026}. Mitochondrion matrix {ECO:0000269|PubMed:19014353, ECO:0000269|PubMed:31081026}. Nucleus, nucleolus {ECO:0000269|PubMed:31081026}.
Interaction partners:
Sequence:
MGRRFLRGILTLPLRSVLQAQHRMLGSEQDPPAKRPRNNLMAPPRIGTHNGTFHCDEALACALLRLLPEYANAEIVRTRDPEKLASCDIVVDVGGEYNPQSHRYDHHQRTFTETMSSLCPGKPWQTKLSSAGLVYLHFGRKLLAQLLGTSEEDSVVDTIYDKMYENFVEEVDAVDNGISQWAEGEPRYAMTTTLSARVARLNPTWNQPNQDTEAGFRRAMDLVQEEFLQRLNFYQHSWLPARALVEEALAQRFKVDSSGEIVELAKGGCPWKEHLYHLESELSPKVAITFVIYTDQAGQWRVQCVPKEPHSFQSRLPLPEPWRGLRDKALDQVSGIPGCIFVHASGFIGGHHTREGALNMARATLAQRPAPVPLANAVVQ
Protein: Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) (P08833)
Organism: Homo sapiens (Human)
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Subcellular location: Secreted {ECO:0000269|PubMed:38246959}.
Interaction partners:
- Insulin-like growth factor 2
- Insulin-like growth factor 1
- Insulin
- Insulin-like growth factor-binding protein 4
- Insulin-like growth factor-binding protein 6
- Alpha-2-HS-glycoprotein
- Insulin-like growth factor 1 receptor
- Alpha-fetoprotein
- Forkhead box protein O1
- Cyclic AMP-dependent transcription factor ATF-4
Sequence:
MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN
Protein: SH3 domain-containing protein (Q7YTG1)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MTPRSDHRGPSMGYGNGGSVDQRVDDVTPSYYVEHLATFAVGRQFGLTFPADGIRKLKQMEKNSAIWAQPLILRFRHNAVTVEDDNGELVEQFPLELIEQPTAHVSNDSRETYNNVLLFVVREDRKRMSTPTEMHIFQCIRVSATDVAEDLKNYVQGQFRRVRNGRRTAAPTHLQAQQQQMPFYPPDDASISSETSEMFERDVNTLNRCFDDIERFVARIQSAALAQREIEQQNHRYRTANRRDKKNQQPPDPNGILFMRAQLPLESEFVDILKKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLAVILEACHWGLGRNVAPTVASPLLSLEARELMQNCLTSHESDIWMSLGEAWRTPPEDWTKPLPPPYRPIFNDGFAPYGVADRAMATPNQIHRGHSAPPEHFRQPPPRERNMVDTLEFDRLTLERERLEFEKAKIMERESRLRHEEKQIEDEKRRMHAEKDLITKETTQPVPPPAAVVTHQPITKRYDPPISISPPPQRNNYSHVKVTVDSDTSPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFDERNWWECKNMHQRVGYVPHTILSMVPFEQQQYASPNHHNNSSSTGGYNNGHHQGPAQNVYRPPPPPLVSDAGVQVEIRREHVAPPPPPVVIPPPPPPVRTPTMEELLRMQQQQQQKQRKPPVEEPVYQPQPAQRAGLEIWRRNQNPQLIQEVTETVGQHSGDILRPAMQRATRVAINEKSSPEDVTRWLQEKGFSPRVIDLLDGQDGANLFSLSKLHLQQACGRDEGGYLYSQLLVQKKRSGFRTHTGDELKAILNHRRTHVELSNEAAADEPVFTINPIL
Protein: Factor of DNA methylation 2 (Protein IDN2 PARALOG 2) (Protein IDN2-LIKE 2) (F4JH53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Forms a complex with IDN2 and FDM1/IDNL1 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway.
Interaction partners:
- Protein DEFECTIVE IN MERISTEM SILENCING 3
- DNA-directed RNA polymerase V subunit 1
- Protein RNA-directed DNA methylation 3
- Rab3 GTPase-activating protein catalytic subunit
- Alpha/beta-Hydrolases superfamily protein
- Defensin-like protein 268
- F-box/FBD/LRR-repeat protein At1g13570
- Putative defensin-like protein 288
- Protein CHROMATIN REMODELING 35
- Protein RDM1
Sequence:
MDISDEESEISESEIEEYSKTPYHLLRSETYYKVKVNGRLRCPFCVGKKKQDYKYKELHAHATGVSKGSATRSALQKSNHLALAKFLENDLAGYAEPLPRPPVVPPLLDETEPNPHNVYVWPWMGIVVNPLKETDDKELLLDSVYWLQTLSKFKPVEVNAFWVEQDSIVGVIAKFDSDWSGFAAATELEKEFETQGSCKKEWTERSGDSESKAYGWCARADDFQSQGPIGEYLSKEGTLRTVSDILQNNVQDRNTLLDVLSNMIDMTNEDLNKAQHSYNRTAMSLQRVLDEKKNLHQAFAEETKKMQQMSLRHIQRILYDKEKLRNELDRKMRDLESRAKQLEKHEALTELERQKLDEDKRKSDAMNKSLQLASREQKKADESVLRLVEEHQRQKEDALNKILLLEKQLDTKQTLEMEIQELKGKLQVMKHLGDDDDEAVQTKMKEMNDELDDKKAELEDLESMNSVLMTKERQSNDEIQAARQKMIAGLTGLLGAESDIGVKRMGELDEKPFLDVCKLRYSANEARVEAATLCSTWKENLKNPSWQPFKREGTGDGAEEVVDEDDEQLKKLKREWGKEVHNAVKAALVEMNEYNASGRYPTSELWNFKEGRKATLKEVITFISTDIKNLKRKRT
Protein: Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Q9ZV45)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365053}.
Interaction partners:
- PHD finger-like domain-containing protein 5A
- Small nuclear ribonucleoprotein Sm D2
- Probable small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein SmD3b
- PHD finger-like domain-containing protein 5B
- Small nuclear ribonucleoprotein SmD3a
- Small nuclear ribonucleoprotein G
- Probable small nuclear ribonucleoprotein G
- U2 small nuclear ribonucleoprotein A'
- Sm protein F
Sequence:
MASTKVQRIMTQPINLIFRFLQSKARIQIWLFEQKDLRIEGRITGFDEYMNLVLDEAEEVSIKKNTRKPLGRILLKGDNITLMMNTGK
Protein: Type IV methyl-directed restriction enzyme EcoKMcrBC (EcoKMcrBC) (Protein McrC) (P15006)
Organism: Escherichia coli (strain K12)
Function: Modifies the specificity of McrB restriction by expanding the range of modified sequences restricted. Does not bind to DNA.
Interaction partners:
- Type IV methyl-directed restriction enzyme EcoKMcrB subunit
- Type IV methyl-directed restriction enzyme EcoKMrr
- Type IV methyl-directed restriction enzyme EcoKMcrA
- Protease 7
- Gamma-glutamyl phosphate reductase
- Type I restriction enzyme EcoKI specificity subunit
- Ornithine carbamoyltransferase subunit F
- Beta-galactosidase
Sequence:
MEQPVIPVRNIYYMLTYAWGYLQEIKQANLEAIPGNNLLDILGYVLNKGVLQLSRRGLELDYNPNTEIIPGIKGRIEFAKTIRGFHLNHGKTVSTFDMLNEDTLANRIIKSTLAILIKHEKLNSTIRDEARSLYRKLPGISTLHLTPQHFSYLNGGKNTRYYKFVISVCKFIVNNSIPGQNKGHYRFYDFERNEKEMSLLYQKFLYEFCRRELTSANTTRSYLKWDASSISDQSLNLLPRMETDITIRSSEKILIVDAKYYKSIFSRRMGTEKFHSQNLYQLMNYLWSLKPENGENIGGLLIYPHVDTAVKHRYKINGFDIGLCTVNLGQEWPCIHQELLDIFDEYLK
Protein: Meiotically up-regulated gene 60 protein (O74359)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Meiotically up-regulated gene 28 protein
- Meiotic PUF family protein 1
- Uncharacterized ribonuclease C609.01
- Meiotic coiled-coil protein 2
- RNA-binding protein mde7
- Meiotically up-regulated gene 24 protein
- Large ribosomal subunit protein uL1m
Sequence:
MDSHVLAFPIPDPSTPPPEEASLYASKCDYYESDIYSQIRRLTEEKCIETEKELPVNIKLHVKHKGMSISSSRNELVVTVSGNYKNVYTAKIKILQAIPKILISKLVLEEPLENLLFDEDGYVYEDTMKHLDKITEITGAKIYIMHRSMCHDIDFQLRTDSGFSNRLNEQQSFYQRHLESTRHEFSCQKNAENSFFIVFYGDYCSVEHARIRVLALMDEIRGLSVVAIATSVSFQPILVGKAFSSTAGMKATESINIYTLPFCSDSIPRLQTLPALNSSKIIITGEEEKLQRLEEAFYYAEEHLKLFTHVTEISFVKLFEFLAYEMDELRLIMEENSSFIRFPEYFKEGGETSPENSKVKIYSSSIANSEKTALRLAKLASKYVQGKTQFGVEDNEDFLRVAGSWRRASTIEKGVSSSELSSIVSSTGSIVETNGIGEKMSFSPLKKLSIPPTEFVAQIAIICMASGVEMLLKTNGIEYFGQENTVPIAMDKASKIFYKFGQSQWHQILLEAPTKDQDFISGKKNGKLDKVKQQCRFNLKNGDILFCPQSTSIFTVDIYSDELERVIKGMNTMLLEFPAEMHFYVPEEIHKKLIGFRGEQIQRVTKLYNSYIEFSTTPFDCYGHNVLIRTPSKFSENLWAVRSLFIKTAEGLGYDIPKYLFAN
Protein: GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) (Q99501)
Organism: Homo sapiens (Human)
Function: Involved in the cross-linking of microtubules and microfilaments. Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24706950}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:24706950}. Note=Colocalizes with the tips of microtubule plus ends. {ECO:0000269|PubMed:24706950}.
Interaction partners:
- Ras-like protein family member 10A
- AP-1 complex subunit beta-1
- Microtubule-associated protein RP/EB family member 3
- Microtubule-associated protein RP/EB family member 1
- Lipase member I
Sequence:
MADPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGFLTGLATGTTLCQHANAVTEAARALAAARPARGVAFQAHSVVPGSFMARDNVATFIGWCRVELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQFEQEIERELRAAPPAPNAPAAGEDTTETAPAPGTPARGPRMTPSDLRNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSSTAHRPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETPPRPRDQLPPHPRSRRYSGDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPALRSQSRDRLDRGRPRGAPGGRGAQLSVPSPARRARSQSREEQAVLLVRRDRDGQHSWVPRGRGSGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPASIFRTPLQLDPQQEQQLFRRLEEEFLANARALEAVASVTPTGPVPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGDSGRTANGLPGPRSQALSSSSDEGSPCPGMGGPLDAPGSPLACTEPSRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPAELGTWHALHSVTPRAEPDSWM
Protein: Zinc finger CCCH domain-containing protein 25 (AtC3H25) (Q9ZW36)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Pre-mRNA-splicing factor SPF27 homolog
- Cell division cycle 5-like protein
- Tetratricopeptide repeat
- AT3G18790 protein
- Pre-mRNA-processing factor 19 homolog 1
- Protein pleiotropic regulatory locus 1
- Pre-mRNA-processing factor 19 homolog 2
- Pre-mRNA-splicing factor SYF2
- Cwf15 / Cwc15 cell cycle control family protein
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
Sequence:
MAHRILRDHEADGWERSDFPIICESCLGDNPYVRMTKANYDKECKICTRPFTVFRWRPGRDARYKKTEVCQTCCKLKNVCQVCLLDLEYGLPVQVRDTALNISTHDSIPKSDVNREFFAEEHDRKTRAGLDYESSFGKIRPNDTIRMLQRTTPYYKRNRAHICSFFIRGECTRGDECPYRHEMPETGELSQQNIKDRYYGVNDPVALKLLGKAGEMGTLESPEDQSIRTLYVGGLNSRVLEQDIRDQFYAHGEIESIRILAEKACAFVTYTTREGAEKAAEELSNRLVVNGQRLKLTWGRPQVPKPDQDGSNQQGSVAHSGLLPRAVISQQQNQPPPMLQYYMHPPPPQPPHQDRPFYPSMDPQRMGAVSSSKESGSSTSDNRGASSSSYTMPPHGHYPQHQPYPPPSYGGYMQPPYQQYPPYHHGHSQQADHDYPQQPGPGSRPNPPHPSSVSAPPPDSVSAAPSGSSQQSADAAVTTGSSQ
Protein: UDP-glucuronosyltransferase (EC 2.4.1.17) (F1QRI1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Membrane {ECO:0000256|RuleBase:RU362059}; Single-pass membrane protein {ECO:0000256|RuleBase:RU362059}.
Interaction partners:
Sequence:
MAAFVLLLYLFCLATAEAGNILVVPSDGSHWTGMKPLVEELGRRGNQVVVVIPEASLSMGPSQHTTTLSYPVSYTKAQIQEIVKAGVTTLISTYVSTDLPRFQSFINRMNSLSNIIIRSAEGFLSNKDLIKKLQDYNFDVILTDPFELVGVIAAEYLSVPAIYIQTSHPCNVDTLASQCPSPPSYVPHILTHFSDRMNLWQRSVNFIRTLIQPMACRRMFTRADEIASRVLQRKTSIMDIMSHAALWFVHSDFALEFPHPLMPNMIIVGGMDNTKAEPLSQELEEFVNGSGEHGFVVFTLGSMVSQLPEAKAREFFEAFRQIPQRVLWRYTGPVPENAPKNVKLMKWLPQNDLLGHPKVRAFVTHGGSHGIYEGICNGVPMVMLPLFGDQGDNAQRLVSRGVAESLTIYDVTSEKLLVALKKVINDKSYKEKMMKLSAIHRDRPIEPLDLAVFWTEFVMRHKGAEHLRPAAHDLNWIQYHSLDVIGFLLLILLTVIFVTVKSCMFCFRKCFKKSQKKKKA
Protein: Molybdate-binding protein ModA (Molybdate/tungstate-binding protein ModA) (P9WGU3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the transport of molybdenum into the cell. Part of the binding-protein-dependent transport system ModABCD (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Molybdenum transport system permease protein ModB
- Molybdenum import ATP-binding protein ModC
- Sulfate transport system permease protein CysT
- Probable sulfate-transport integral membrane protein ABC transporter CysW
- GTP 3',8-cyclase 2
- Cyclic pyranopterin monophosphate synthase 2
Sequence:
MRWIGLSTGLVSAMLVAGLVACGSNSPASSPAGPTQGARSIVVFAAASLQSAFTQIGEQFKAGNPGVNVNFAFAGSSELATQLTQGATADVFASADTAQMDSVAKAGLLAGHPTNFATNTMVIVAAAGNPKKIRSFADLTRPGLNVVVCQPSVPCGSATRRIEDATGIHLNPVSEELSVTDVLNKVITGQADAGLVYVSDALSVATKVTCVRFPEAAGVVNVYAIAVLKRTSQPALARQFVAMVTAAAGRRILDQSGFAKP
Protein: Putative F-box/LRR-repeat protein At3g42770 (Q9M190)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MNCLPDELLVQILSFLPTKEATSTSLLSKRWRTLFTLSPNLDFDNSLLLQSKKRKWNMRNIQKSFVGFVDSTLALQGGKGIKSFSLKFKETLGDVNGEVDVNRWICNALEHGVSELHLRIDYTKRCHLPSEIFTSTKLVKLSLVTQSCFPVVPNCISLPSLKVLFLDSIWFEVPQFLIFLTACPALEDLTIYQKPHSVGMPYHISSKTIKRLSVTYTCGYFVDYGLKLFNTPSVVDLYYSDYVRHKYPHMNLDSLPKATLDIHFLDDNAANVTELLSGIRNVKTLHLTSSTVKVILLCCKGEIPMFENLINLKFSGKTRQWKFLLPLLLEICPNLTTLVLSGLDQNWFVGFRTPPNNQVKMLSIMQYQGSERELKLISYFVLKMECLQVVKVYVSSPMNDLKKMQLTEDLLKLPKASPKLNIQVLVPSDTYLPALKVLFLDSVWFDFHQFANVFFPACPALEDFAIHIKSFRRKARSENELEHISHFSLKMEFLEVLKVYVALTMDDTKKVELTKELLKLPISSSKLIIQVM
Protein: Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)] (Q9R0E1)
Organism: Mus musculus (Mouse)
Function: Multifunctional enzyme that catalyzes a series of post-translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the ADIPOQ collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV collagens. Essential for normal formation of basement membranes.
Subcellular location: Rough endoplasmic reticulum {ECO:0000250|UniProtKB:O60568}. Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:O60568}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16447251}; Peripheral membrane protein {ECO:0000305|PubMed:16447251}; Lumenal side {ECO:0000305|PubMed:16447251}. Secreted {ECO:0000269|PubMed:21465473}. Secreted, extracellular space {ECO:0000269|PubMed:16447251}. Note=The majority of the secreted protein is associated with the extracellular matrix. {ECO:0000269|PubMed:16447251}.
Interaction partners:
- Procollagen galactosyltransferase 1
- Procollagen galactosyltransferase 2
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
- Calmodulin-lysine N-methyltransferase
- Histone-lysine N-methyltransferase EHMT2
- Collagen alpha-1
- Prolyl 4-hydroxylase subunit alpha-1
Sequence:
MAAAGPEPRLLLLLLLLLPPLPPVTSASDRPRGANAVNPDKLLVITVATAETEGYRRFLQSAEFFNYTVRTLGLGQEWRGGDVARTVGGGQKVRWLKKEMEKYADQKDMIIMFVDSYDVILASSPTELLKKFVQSGSHLLFSAESFCWPEWGLAEQYPEVGMGKRFLNSGGFIGFAPTIHQIVRQWNYKDDDDDQLFYTQLYLDPGLREKLKLSLDHKSRIFQNLNGALDEVILKFDQNRVRIRNVAYDTLPVVVHGNGPTKLQLNYLGNYVPNGWTPQGGCGFCNQTLRTLPGGQPPPRVLLAVFVEQPTPFLPRFLQRLLLLDYPPDRISLFLHNSEVYHEPHIADAWPQLQDHFSAVKLVGPEEALSAGEARDMAMDSCRQNPECEFYFSLDADAVLTNPETLRVLIEQNRKVIAPMLSRHGKLWSNFWGALSPNEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGETLRTELPQKEVFSSSDTDPDMAFCKSVRDKGIFLHLSNQHEFGRLLATSRYDTDHLHPDLWQIFDNPVDWREQYIHENYSRALDGEGLVEQPCPDVYWFPLLTEQMCDELVEEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTEYLFPGYHTKTRAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGVDYEGGGCRFLRYDCRISSPRKGWALLHPGRLTHYHEGLPTTRGTRYIMVSFVDP
Protein: Cytochrome c oxidase copper chaperone (P56394)
Organism: Mus musculus (Mouse)
Function: Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:37813994}. Cytoplasm {ECO:0000250|UniProtKB:Q14061}.
Interaction partners:
- Cytochrome c oxidase assembly protein COX11
- Mitochondrial intermembrane space import and assembly protein 40
- Copper transport protein ATOX1
- Protein SCO2 homolog
- Copper chaperone for superoxide dismutase
- Copper-transporting ATPase 2
- High affinity copper uptake protein 1
- Cytochrome c oxidase assembly protein COX19
- Copper-transporting ATPase 1
- Cytochrome c oxidase assembly factor 5
Sequence:
MPGLAAASPAPPEAQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
Protein: Protein BEX2 (Brain-expressed X-linked protein 2) (hBex2) (Q9BXY8)
Organism: Homo sapiens (Human)
Function: Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q3MKQ1}. Nucleus {ECO:0000269|PubMed:16314316}.
Interaction partners:
- Rhombotin-2
- LIM domain-binding protein 1
- LIM domain-binding protein 2
- Helix-loop-helix protein 2
- Calmodulin-like protein 4
- Calmodulin-like protein 3
- Calmodulin-like protein 6
- Calmodulin-like protein 5
Sequence:
MESKEERALNNLIVENVNQENDEKDEKEQVANKGEPLALPLNVSEYCVPRGNRRRFRVRQPILQYRWDIMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP