wanglab/gogpt-training-data huggingface dataset:
Protein: Down syndrome cell adhesion molecule 1, isoform BS (A0A0C4DHD8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNMPNERLKWLMLFAAVALIACGSQTLAANPPDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNPMPEIIWIRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSIISRDVHVRAVVSQHYEEDIHKAFVIRGNSAILKCDIPSFVADFVNVISWHSDEKENFYPGTEYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVSPKISGGRLQEITKSAATDLAILCLGQSFPTPAFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPVLRIESVKKEDKGMYQCFVRNDQESAEASAELKLGGRFDPPVIRQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVPPQIQAFDFGSEAANTGEMAGGFCMVPKGDLPMEIRWTLNSAPIITGEHGFSLSRLNPRTSSLSIDSLEARHRGLYRCIASNKAGSAEYSAELHVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPSRDLPELSAEDTIRIILSNLNLVVPVVAALLVIIIAIIVICILRSKGNHHKDDVVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAGPVPGHAGTMLPPGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTPAPEYDDPANCAEEDQYRRYTRVNSQGGSLYSGPGPEYDDPANCAPEEDQYGSQYGGPYGQPYDHYGSRGSMGRRSIGSARNPGNGSPEPPPPPPRNHDMSNSSFNDSKESNEISEAECDRDHGPRGNYGAVKRSPQPKDQRTTEEMRKLIERNETGPKQLQLQQANGAGFTAYDTMAV
Protein: DNA-directed RNA polymerase V subunit 5A (Q9M1J2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase V involved in RNA-directed DNA methylation-dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements. Required for establishment of DNA methylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:10231567}.
Interaction partners:
- DNA-directed RNA polymerases II, IV and V subunit 11
- DNA-directed RNA polymerases II, IV and V subunit 9B
- DNA-directed RNA polymerases II, IV and V subunit 8B
- DNA-directed RNA polymerases II, IV and V subunit 3
- DNA-directed RNA polymerases IV and V subunit 3B
- DNA-directed RNA polymerases II and V subunit 8A
- DNA-directed RNA polymerases IV and V subunit 4
- DNA-directed RNA polymerases II and V subunit 6B
- DNA-directed RNA polymerases II, IV and V subunit 6A
- DNA-directed RNA polymerases II, IV and V subunit 10
Sequence:
MEVKGKETASVLCLSKYVDLSSEESHRYYLARRNGLQMLRDRGYEVSDEDINLSLHDFRTVYGERPDVDRLRISALHRSDSTKKVKIVFFGTSMVKVNAIRSVVADILSQETITGLILVLQNHVTNQALKAIELFSFKVEIFQITDLLVNITKHSLKPQHQVLNDEEKTTLLKKFSIEEKQLPRISKKDAIVRYYGLEKGQVVKVNYRGELTESHVAFRCVW
Protein: Poly(A) binding protein, nuclear 1 (A0A8I6A5F1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGDPGGAGDYGNGLESEELEPGELLPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVETDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSLEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVSLGPWLLSILYRFSSLTPRLSVLCPFQVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRIYRSG
Protein: Chd3 protein (Q7TML9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MKADVTRLPATLSRIPPIAARLQMSERSILSRLASKGTEPHPTPAFPPGPYATPPGYGAAFSAAPVGALAAAGANYSQMPAGSFITATTNGPPVLVKKEKEMVGALVSDGLGLDRKEPRAGEVICIDD
Protein: DNA-directed RNA polymerases II, IV and V subunit 12 (DNA-directed RNA Polymerase II subunit K) (Q9FLM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA-directed RNA polymerases IV and V subunit 2
- DNA-directed RNA polymerases II, IV and V subunit 6A
- DNA-directed RNA polymerases II, IV and V subunit 10
- DNA-directed RNA polymerases II and IV subunit 5A
- DNA-directed RNA polymerases II, IV and V subunit 9A
- DNA-directed RNA polymerases II, IV and V subunit 11
- DNA-directed RNA polymerases II, IV and V subunit 8B
- DNA-directed RNA polymerases II, IV and V subunit 3
- DNA-directed RNA polymerases II and V subunit 6B
- DNA-directed RNA polymerase II subunit 4
Sequence:
MDPAPEPVTYVCGDCGQENTLKSGDVIQCRECGYRILYKKRTRRVVQYEAR
Protein: Alkaline ceramidase 1 (AlkCDase 1) (Alkaline CDase 1) (maCER1) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3) (Q8R4X1)
Organism: Mus musculus (Mouse)
Function: Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide. May also hydrolyze dihydroceramides to produce dihydrosphingosine (By similarity). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12783875}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neutral ceramidase
- Acid ceramidase
- Ceramide synthase 4
- Ceramide synthase 3
- Ceramide kinase
- Sphingosine kinase 2
- Ceramide glucosyltransferase
- Ceramide synthase 2
- Ceramide synthase 6
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
Sequence:
MHVPGTRAKMSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPYAQKRTRCFYGVSVLFMLIGLFSMYFHMTLSFLGQLLDEISILWLLASGYSVWLPRCYFPKFVKGNRFYFSCLVTITTIISTFLTFVKPTVNAYALNSIAIHILYIVRTEYKKIRDDDLRHLIAVSVVLWAAALTSWISDRVLCSFWQRIHFYYLHSIWHVLISITFPYGIVTMALVDAKYEMPDKTLKVHYWPRDSWVIGLPYVEIQENDKNC
Protein: RNA-binding protein spenito (Q7KMJ6)
Organism: Drosophila melanogaster (Fruit fly)
Function: RNA-binding protein that acts as an associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs. M6a modification plays a role in the efficiency of mRNA splicing and is required for sex determination. In the WMM complex, may act by binding target RNAs and recruiting the WMM complex. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Acts as a positive regulator of canonical Wg signaling during wing disk and eye development.
Subcellular location: Nucleus {ECO:0000269|PubMed:18174108, ECO:0000269|PubMed:26324914, ECO:0000269|PubMed:28675155}.
Interaction partners:
- Fl
- Pre-mRNA-splicing regulator female-lethal
- N
- N
- Protein virilizer
- E3 ubiquitin-protein ligase Hakai
- Uncharacterized protein
- Uncharacterized protein, isoform A
- YTH domain-containing protein 1
- Uncharacterized protein, isoform A
Sequence:
MSSHRDGAGADRITIKIHNMKRSASRSPGPASRSSLSRNSRSMGRGYDNGSGVPGDSPERLSPERMRRRLDRSPSRYGSPHREPYMRGPPPAERPAGYKVLCVSALPPKAPDDFIEETLYREYKKFGDFSVRLAHDLDERVAYVCFRTPEDAREAKHHKPRLIIYDKMAIVEPVYKSTTRPEYRPRGHSMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDYPHPPRGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQYETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAAPFKSSKPPYDESALEYRRPEYDPYYEESAAYAPRGGYSPYPPRGGYRGRGGYRGRGRGMYHYHNDVHRPPHPGSLAGSSSSVPPPGGVEDEWRRPPGESYDRGARSSSREPGVERSRSRSPLKRARSPGSDSDTSTRRNDALASASTVPDVARKCSTVWTGALILKSSLFPAKFHLTDGDTDIVESLMRDEEGKHNLRITQRLRLDPPKLDDVQKRIASSSSHAIFMGLAGSTNDTNCDDASVQTRPLRNLVSYLKQKEAAGVISLLNKETEATGVLYAFPPCDFSTELLKRTCHSLTEEGLKEDHLVIVVVRGGTA
Protein: Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (Stem cell-derived tyrosine kinase) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] (Q62190)
Organism: Mus musculus (Mouse)
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Hepatocyte growth factor-like protein
- Hepatocyte growth factor
- E3 ubiquitin-protein ligase CBL
- E3 ubiquitin-protein ligase CBL-C
- E3 ubiquitin-protein ligase CBL-B
- Catenin beta-1
- Epidermal growth factor receptor
Sequence:
MGLPLPLLQSSLLLMLLLRLSAASTNLNWQCPRIPYAASRDFSVKYVVPSFSAGGRVQATAAYEDSTNSAVFVATRNHLHVLGPDLQFIENLTTGPIGNPGCQTCASCGPGPHGPPKDTDTLVLVMEPGLPALVSCGSTLQGRCFLHELEPRGKALHLAAPACLFSANNNKPEACTDCVASPLGTRVTVVEQGHASYFYVASSLDPELAASFSPRSVSIRRLKSDTSGFQPGFPSLSVLPKYLASYLIKYVYSFHSGDFVYFLTVQPISVTSPPSALHTRLVRLNAVEPEIGDYRELVLDCHFAPKRRRRGAPEGTQPYPVLQAAHSAPVDAKLAVELSISEGQEVLFGVFVTVKDGGSGMGPNSVVCAFPIYHLNILIEEGVEYCCHSSNSSSLLSRGLDFFQTPSFCPNPPGGEASGPSSRCHYFPLMVHASFTRVDLFNGLLGSVKVTALHVTRLGNVTVAHMGTVDGRVLQVEIARSLNYLLYVSNFSLGSSGQPVHRDVSRLGNDLLFASGDQVFKVPIQGPGCRHFLTCWRCLRAQRFMGCGWCGDRCDRQKECPGSWQQDHCPPEISEFYPHSGPLRGTTRLTLCGSNFYLRPDDVVPEGTHQITVGQSPCRLLPKDSSSPRPGSLKEFIQELECELEPLVTQAVGTTNISLVITNMPAGKHFRVEGISVQEGFSFVEPVLTSIKPDFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCRLEQVNEEQILCVTPPGAGTARVPLHLQIGGAEVPGSWTFHYKEDPIVLDISPKCGYSGSHIMIHGQHLTSAWHFTLSFHDGQSTVESRCAGQFVEQQQRRCRLPEYVVRNPQGWATGNLSVWGDGAAGFTLPGFRFLPPPSPLRAGLVELKPEEHSVKVEYVGLGAVADCVTVNMTVGGEVCQHELRGDVVICPLPPSLQLGKDGVPLQVCVDGGCHILSQVVRSSPGRASQRILLIALLVLILLVAVLAVALIFNSRRRKKQLGAHSLSPTTLSDINDTASGAPNHEESSESRDGTSVPLLRTESIRLQDLDRMLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHGDLLHFIRSPQRNPTVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEVKQVVASLLGDHYVQLTAAYVNVGPRAVDDGSVPPEQVQPSPQHCRSTSKPRPLSEPPLPT
Protein: Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar) (Q7L099)
Organism: Homo sapiens (Human)
Function: Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25766321}. Endomembrane system {ECO:0000269|PubMed:20376209}. Cell projection, invadopodium {ECO:0000269|PubMed:25766321}. Perikaryon {ECO:0000250|UniProtKB:Q9D394}. Cell projection {ECO:0000250|UniProtKB:Q9D394}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9D394}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9D394}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9D394}. Lysosome {ECO:0000269|PubMed:35314674}. Note=Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery (PubMed:25766321). Colocalizes with Ras-related Rab-5 proteins in cytoplasmic vesicles (PubMed:20376209). Accumulates in axon growth cones in a F-actin-dependent manner (By similarity). Colocalizes with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (By similarity). Colocalizes with DBN1 and F-actin at transitional domain of the axonal growth cone (By similarity). Recruitment to endolysosomes partially depends upon the presence of ARL8 (PubMed:35314674). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:20376209, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:35314674}.
Interaction partners:
- Shootin-1
Sequence:
MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH
Protein: Ethylene-responsive transcription factor ERN1 (ERF transcription factor ERN1) (Protein ERF REQUIRED FOR NODULATION 1) (LjERN1) (A0A1X9PY88)
Organism: Lotus japonicus (Lotus corniculatus var. japonicus)
Function: Transcription factor involved in the symbiotic nodule signaling pathway in response to rhizobial stimulation. Functions as a transcriptional regulator required for root infection by symbiotic rhizobia, infection thread (IT) formation, and nodule development. May coordinate these processes. Functions downstream of the CCAMK-CYCLOPS complex. Probably not involved in arbuscular mycorrhizal (AM) symbiosis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366}.
Interaction partners:
Sequence:
MEIQFQQPNLQQHQKAGTKGGKFKGRNRNSNTNKFVGVRQRPSGRWVAEIKDTTQKIRMWLGTFETAEEAARAYDEAACLLRGSNTRTNFITHVSLDSPLASRIRNLLNNKKGNKKQEGVVDVGVDVDVPAPSASTTSTSSNTSNSDKNDHNSLSSGKVQNTMLFDDAYKPDLSNCKEDFQSCPPQSNFSWGFGPVFDRFPIAQILDMPKTDGMIDAASLELSEFERMKVERQISASLYAINGVHEYMETVQDSNETLWDLPPLCSLFC
Protein: LD07532p (Q7KLW5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
Interaction partners:
Sequence:
RSSNNHPTSKMFASNTRNLMRSSILQRCKSTLVVAEHNNEVLNPITLNTISAAKKIGGDVTVLVAGTKCGPASEALSKVDGVTKVLVAENAAFNGFTAESLTPLVLAAQSQFKFTHILAGASAFGKNVLPRVAAKLDVSPISEIIDVKSDDTFVRTIYAGNAILTLKSKDAVKVITVRSTNFPPAATSGGSGAVEQAPAGDFASSLSEFVSQELTKSDRPELAGAKVIVSGGRGLKSGDNFKLLYDLADKFGAAVGASRAAVDAGFVPNDLQIGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADIGIVADLFKAVPELTGKL
Protein: Protein kinase, putative (Q38B72)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- CBS domain-containing protein
- Association with the SNF1 complex
Sequence:
MSQRFGPYRVGETIGRGTFAKVKIAVHELTDTKVALKIIPRKVMDDSKSSTKLTREIGILRTLQHPNIMKLYQVVQTKQDIVLILEYVSGGELFDYICQRGPLAEDVVRHIFQQIAAGVAYCHRYRVIHRDLKPENILLEKNTNTVKIADFGLSSYTHDGRFLETSCGTPNYASPQVVSGEMYAGPDTDVWSCGVILYTMLVGALPFEDTNVAALFQKIKRAEYLVPESVSPQAHDLLRRMLVVNPLERATMEQVIQHPWVRPHYPPCLLSLHYDAILHSMRFGKSLELCGEELDEKVVEDVAELFEVPTSEVAAAISKYDNSMSGLFTSNTGTDGEAATRYPAQSFYESYANAVDVKHWPSPLVISHAEKALRDKENNMYVSYLILLQRKQQETPLQALPSSDLTTDAVGSFFMSMGVNQGYGSLTANSLQPMSLFGISLPQSLAPQSNGDALQLMQKQGNVTFCGSLPAHVQAEKLELVEIDAYMESYNKVVEPFIPLYSSTSKRTLLGKLFRVTEIPVSVNSDLSSLRGSFASTVDEELGGSLIRSMVGSRSAPASSHRDPNRLLRPLSSTKKQKISKTTAEKSRAKRVDTAGSAAGKSSEVLQCNVVAKPGFNGYMHNGVRFVNIDAAATLRCVYSSLKAEGLLWKQIRPFYLAAVMHPCVKLQVRIFRIQANDQVVDVRVSSQSGMMGCVTAAKLIDRLWSKAVALTPVKVEEGPRLGKFTVCT
Protein: Thyroglobulin (A0A193GP06)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MQNMEEMKLLCLTSTLICIFSLTCGKISEYQLETESLSQCEQLRSVSAEQERQHVPQCFEDGRFRHVQCNRGGGECWCVNAEGFEIPGSRQNGSSVYCLTTCQLQRQRALQTEDATLVPVCLDSGEYQQVQCDASRSQCWCVDLEGMEIYGTRQNGKPSKCPGTCEVRERRLLHGIGERSPPQCSDDGGFLPVQCKFVNTTDRMIFDLLHTFNRQPEVFQTFSGFRKAYPELSSYCFCADSRGREMPSTGVELLLDEVYDTAFSDQTAGSSFAESNMYRILNRRYLAVQLAINGKFRCPSPCESERAAASQAGNSFVPSCTDNGAYVPTQCQSGGQCWCVDTYGKEIFGTRQNGVPKCSTGVKDCLSERRQALSKLFYGPAGGFSNSNVFSSSKDTVSFLGTCSPEFQELLANSGLLQSLPELERPKVTNILADVLQGMFPSGALALKALALAQNPKRLQENLFGGKFLKNAGNFNFSGTVGDSGTLSFRQIFSQVGLTQVVTDLMQLAKTFTDSSENLNLDQEISDAFGRSVNLKNNREMIKLVSMALENTHFLSTLRVAIKQLKAEETTQLGSLFRDIFQKSDVCKPMSSSSAPYLPQCTEDGLYQDVQCQGSECWCVDSRGLEVPGSRTTGSRPRCPSQCEKERQMAIAVKASSSAGSEVFIPKCETDGAYVARQCLGKSCFCVDRSGTKLGIQSSGSSLQCPTSCQAIAIQQFQSTVRSLLSDPPSVTQLSEIYIPRCSYDGSWHQIQCDGPPEQAIEFYREWVRIINLGQDLPASELLGILQTYARNTEAMASFRAFVSELFKIGHHRVFPVLARFQKFSDIPSDLLDGNSEAVYGPSVYLNPLSLWRLIRLDDSGYPGLLSDFSVPLGSFDLRQCWCVDLEGDMLAGSKAPVGQIPKCPGPCSVVQSQVSEFLKQAEELISASNSTHVPVGYGFLLAESVYLSPEELEQTRSSMIPVTQTLLSNTDLALRLAAHSTLHFYWQSRLMASDRDRQSLMLGYQPYIPQCDAYGQWLPNQCYQSTGLCWCVDEEGQYIADSLTSRSSLPQMCQTLCQRLQSHTLLSDWRQTSSNITYTYRPSCEEDGEFSVLQKATSGHMQGFCVSPITGRVIQPAITNSSGELQCPGWCSLQKTLALQREVALGYEPECVQDGQHFSPLQCDLSDCWCVSDSGKELPMTRSPRSTGQTPACNIPECPLPFGDISHGAVLCSSTNVPSQQMQRCELYCDQSYVNTLPVASFLCDPQAKNWLEDAPLSNACQKPQVLQTVQVSVQLQLSLNEGQQSCSTQSVDLQAALLRDMRATGLCSLQLTSSGQTSSVSVCDESSVSLECSNDKEVTARITLMARLSDLPLAALPDLHDIDTALSEERLLNGLKKLILSGSYQSIFLSDHSLALSSPPSFSCMTGYSQLPQSTGCVLCPAGSFFSGGVCTPCPRDTFQEDEGQVFCSPCPAGTSTVAQGAFSASHCLTECKKSKLSCTTKGDFLSAQKDPVSGKWRCVSAQGEELTWTSSDGLLTVEECKVMEKFEVVSSSSLLLKSESADTLSSDSSSQPKETQLRKCVLDCAQDDSCLYVAVFSDEEKTHCEMYSTSADNVECRTTEPSKGFLGNDGAEAFQTLICVLKIKGDEPDLTVLRKKGHEFSTAGLKRFERLSFRKAGSGVYRTLVFDARGSALADVHRFCVDSCGRETCCDGFILNQNVLNGGSIMCGFLTAPTVLQCSESDWDVKSLSSSSRICGAGVQYSKQLKRFTFSFGGQNFTITDAALPASSKNKTGYQETLISFQRVYLWKESDMNTRAKTLSACSGSAVGEDSRSALSDSVKEAFDVLDSGDVNVDPERELPNQLYWIFKHQYSFQEAQLWCLKRCEEEELCHVSDIRDEGPLYFACVLYPDTRVCGAYDKPLRQTCSLVMTQSLQTAYQKKVSLTGSVKSFYSRVPFKKMVSYSVRSRVSVSSKPITEGFFECERRCDEDPCCRGIGYVKDSGVAGSDVLCLTLNSLGIQTCGENDSTSWRIQDCSPSQVQSQLYPFGWYEKPVNQWPNNPDVCPPFSLRSPSKNADLQKWKKLDVASVYVDASVSAFDIVHISKDIAEDLDKVKNWCLSACEDSESCSAVSIDSRESAVRCVMYPDTHTCLPTTSGRRCLLVTKEPAQSVYIRTGVQLEFTSVSIPDHGTLLGESEVKPITGSDSKRVTYFLGVPYARPPIGDLRFSPPQPADWTGTWNATFFRSSCLQPGDLTDSSSSEDCLYLNVFVASSVAKNAPVLVFFHNSGSDLLDGSYLAAVGNIIVVTASFRMAAFGFLSAGSSALPGNYGLQDQAAALGWVQKNIALFGGDPTKVTVGAERNGADIASLHLTSPSASSLFSRALLMGGSVFSPAVVMSSSKAQAQTSSLARELDCQAADPSQLLDCLRSKPAHSINAAQTKLLAVSGPLQAWSPVVDGNVVREMPSVALQSGRFHKAEILLGSSFEDGLISRAKNIKNFEQLQGRADSKTAFYAALSNSLGGDDANAFVKEAATWFYSLQHSPTPSGYNVFSRALENATRDLFIICPTVDMAEFWAANTQTGVYMYHLPENAAYNSVDLSVPMDVQYLFGVPLAAEQRDLFSYKEKTFTLQIMNYMANFIKSGNPNLPLAASRTSFGKFLPPWPQFMPHVGGRAYKELSSTLVNRKNLQRSQCSFWSQYVPALTSSTAKFSCGTSAEETGVQTPTQEPKPLTPASFTLTPSRQKSEKDAYN
Protein: Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) (Q9UBL3)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May play a role in hematopoiesis. In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.
Subcellular location: Nucleus {ECO:0000305|PubMed:17355966}.
Interaction partners:
- Histone-lysine N-methyltransferase 2A
- CXXC-type zinc finger protein 1
- WD repeat-containing protein 82
- WD repeat-containing protein 5
- PAX-interacting protein 1
- Histone-lysine N-methyltransferase SETD1B
- Host cell factor 1
- Histone-lysine N-methyltransferase SETD1A
- Retinoblastoma-binding protein 5
- Histone-lysine N-methyltransferase 2C
Sequence:
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP
Protein: Glomerular epithelial protein 1 (Protein tyrosine phosphatase receptor type O) (Q28613)
Organism: Oryctolagus cuniculus (Rabbit)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGHLPTRARGRRRLLPLLWLFVLLKTAAAFHVTVRDDNSIVVSLEASDVISPASVYVVKITGESKNYFFEFEEFNSTLPPPVIFKANYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKAFRTMLYKDFFKGKTVFNHWLPGICYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPRNISVRIVNLNKNNWEEQSGSFPEESFMRSPETIEKDRIFHFTEETPEPSGNISSGWPDFNSSDYETTSQPYWWDSASATPESEDEFVSVLPMEYENNNTLSEAEKPTPAPFSFFPVQMILSWLPPKPPTAFDGFHIHIEREENFTEYSTVDEEAHEFVAELKEPGKYKLSVTTFSASGSCETRESQSAKSLSFYISPTGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKRIIENLVPGAQYQVVMYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSGLETKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLLSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQMIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWAHRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS