wanglab/gogpt-training-data huggingface dataset:
Protein: Guanine nucleotide-binding protein G(olf) subunit alpha (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein, olfactory type) (Q8CGK7)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16754875}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- D
- D
- Guanine nucleotide-binding protein G
- Adenylate cyclase type 9
- Adenylate cyclase type 5
- Adenylate cyclase type 3
- Guanine nucleotide-binding protein G
- Adenylate cyclase type 2
- Beta-2 adrenergic receptor
- Guanine nucleotide-binding protein G
Sequence:
MGCLGNSSKTAEDQGVDEKERREANKKIEKQLQKERLAYKATHRLLLLGAGESGKSTIVKQMRILHVNGFNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL
Protein: Dihydrofolate reductase (EC 1.5.1.3) (Q54801)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
Interaction partners:
Sequence:
MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV
Protein: Protein CREG1 (Cellular repressor of E1A-stimulated genes 1) (O75629)
Organism: Homo sapiens (Human)
Function: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.
Subcellular location: Secreted {ECO:0000269|PubMed:10815803}.
Interaction partners:
- Cation-independent mannose-6-phosphate receptor
Sequence:
MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLSLSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKVNETEMDIAKHSLFIRHPEMKTWPSSHNWFFAKLNITNIWVLDYFGGPKIVTPEEYYNVTVQ
Protein: Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) (P17679)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16888089}.
Interaction partners:
- Zinc finger protein ZFPM1
- T-cell acute lymphocytic leukemia protein 1 homolog
- Rhombotin-2
- LIM domain-binding protein 1
- Transcription factor E2-alpha
- Transcription factor PU.1
- Bromodomain-containing protein 3
- Runt-related transcription factor 1
- Krueppel-like factor 1
- Zinc finger protein Gfi-1b
Sequence:
MDFPGLGALGTSEPLPQFVDSALVSSPSDSTGFFSSGPEGLDAASSSTSPNAATAAASALAYYREAEAYRHSPVFQVYPLLNSMEGIPGGSPYASWAYGKTALYPASTVCPSHEDAPSQALEDQEGKSNNTFLDTLKTERLSPDLLTLGTALPASLPVTGSAYGGADFPSPFFSPTGSPLSSAAYSSPKFHGSLPLAPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRMIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYFKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSNLAGAGAAEGPAGGFMVVAGSSSSGNCGEVASGLALGTAGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTTSFPTGPAPTTSSTSVIAPLSS
Protein: Transcription initiation factor TFIID subunit 10 (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30) (mTAFII30) (Q8K0H5)
Organism: Mus musculus (Mouse)
Function: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (By similarity). May regulate cyclin E expression.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q12962}.
Interaction partners:
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 1
- Transcription initiation factor TFIID subunit 3
- Transcription initiation factor TFIID subunit 8
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 9
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 11
- Transcription initiation factor TFIID subunit 12
- TATA-box binding protein associated factor 4
Sequence:
MSCSGSGADPEAATACAASVAGPAPLVSAPAALPTSTAAESKASPAGTAGGPVAGVATAGTGPVAARAGEPAERRGPASVAAGGAAPPEGAMSNGVYALPSAANGEVKPVVSSTPLVDFLMQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTASGSSRSKSKDRKYTLTMEDLTPALSEYGINVKKPHYFT
Protein: Cation transporting ATPase (Cation-transporting P-type ATPase N-terminal domain-containing protein) (G5EBE7)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Probable sodium/potassium-transporting ATPase subunit beta-3
- Sodium/potassium-transporting ATPase subunit beta-1
- Sodium/potassium-transporting ATPase subunit beta
Sequence:
MTRKPQHPGRNGVVDIHESAGTSICSSSADNTVTKEKAKRKRAEKEETDHGMTLHDIIKTSFVEHTLSVDQIRDLYPDSYVFPQCAERSDGLHSDEAKKRLKDGGLNQIDRPQEPSLSRFFLSQFHFKFWILLLGAAVLSVMTYFIHMARGFNEPLNLYCAIILIAVVVFMGMLSYWQQAKAKKVLQENRDMMPVMSYVIRDCEEQEIKADEIVVGDLVYLRAGYKIPADMRILQANCLMIESHDVTGHRMPQEYKSDPVQANVSVFDACNVAFMGSYCTEGEGIGIVIRTGKFTVLGALANQHHHIPPPSGRLQTELQNFSTFISIVAISMATVVFFIGCFVARFENVLDHFIVGFVVIIVANVPQGLPATVMSQLRIIARRMAQKNILIKKLELIDELGAATVICADKSGTLTMNQMVVTDLWFNSRLVTGQAVDLKHPHLRVMKASMKCPERLEEPLPDILTVMSVCNNGQFEHVRRGMRRVSTMRAMQKSASEAMLSAHMKKKFTIVDTRTGQVSGQAGGVMKEADQISETEPTELGKKRVKPKKNDIFGVPSDVALIKYVELSASVEGIRQRYQTVFEIPFNSIRRCQVVVARYLASDFPMTSELVDNPEEGQSRFMIFTKGAPEVILGKCSNYRQGKELKTIDETYRTECQAAWEMLGNEGRRVIAFAQKSFNADDSTKFTGQEYNGDLVFLGMAAIMDPPRPETAAAIEQCKMAGVKVFMITGDHPTTATAIARQIGLIGSSTNLNDVEKPQNSWAVVTGDQLKNYKKSDWNLLLKNHNIVFARTNTEQKLEIVQEVQRRGETVAVTGGGVDDTPVLAHANVGIAMGQSGSDIAKQTADIVLLDDNFASIVMGIEEGRLLFDNLRLSLAYTFAHLWPEVFPIMMSFMLGLPHGLSPLQILSVDLASEMPPAISLAYEQPENDIMHTPPRSRTARLLSKSLLVYAYILAGFGITIGCIAAYLSVYWYHNIPISDILFTAEHHWKIGAKNFTTSQGLTFGEQQQLFIKGQAAAAWQITLVMSQVFHLYNCTTRRVSVFRHGLTNIVSVFAVIIEILLLFMFVYTPVFQYIMDIHTPPAHVWAIAPIVGLYLLAFNEMRKYFIRNFPKNKLVRLIKW
Protein: Uncharacterized protein C11orf97 homolog (Q9DAE7)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27914912, ECO:0000269|PubMed:28666954}.
Interaction partners:
- Sperm acrosome-associated protein 9
Sequence:
MRRQEALAGTASEAGREGEQPRPAGLGCRTRAEPGGPQESRQQWKTFLYCEPHKRIKEVLEEELSIKRDECHVKSPPTVALDGIWSIRRNLPVGGTISGQQSRNSSLPQAKYYSRHGGLRR
Protein: Transmembrane protein 67 isoform 3 (A0A0S2Z5T9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAVWSLLSARAVTAFLLLFLPRFLQAQTFSFPFQQPEKCDNNQYFDISALSCVPCGANQRQDARGTSCVCLPGFQMISNNGGPAIICKKCPENMKGVTEDGWNCISCPSDLTAEGKCHCPIGHILVERDINGTL
Protein: High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma) (P30273)
Organism: Homo sapiens (Human)
Function: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:8611682}.
Interaction partners:
- Low affinity immunoglobulin gamma Fc region receptor III-B
- TYRO protein tyrosine kinase-binding protein
- Natural cytotoxicity triggering receptor 1
- Low affinity immunoglobulin gamma Fc region receptor III-A
- C-type lectin domain family 6 member A
- Tyrosine-protein kinase SYK
- C-type lectin domain family 4 member E
- Platelet glycoprotein VI
- Natural cytotoxicity triggering receptor 3
- High affinity immunoglobulin epsilon receptor subunit alpha
Sequence:
MIPAVVLLLLLLVEQAAALGEPQLCYILDAILFLYGIVLTLLYCRLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQ
Protein: Ly6/PLAUR domain-containing protein 1 (Putative HeLa tumor suppressor) (PHTS) (Q8N2G4)
Organism: Homo sapiens (Human)
Function: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- G-protein coupled receptor 39
- Secreted Ly-6/uPAR-related protein 1
Sequence:
MWVLGIAATFCGLFLLPGFALQIQCYQCEEFQLNNDCSSPEFIVNCTVNVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCCNTPLCNGPRPKKRGSSASALRPGLRTTILFLKLALFSAHC
Protein: Acyl-[acyl-carrier-protein] desaturase (EC 1.14.19.-) (F4IS32)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Interaction partners:
Sequence:
MALKFNPLVASQPYKFPSSTRPPTPSFRSPKFLCLASSSPALSSGPKSVESLKKPFTPPREVHVQVLHSMPPQKIEIFKSMENWAEENLLIHLKDVEKSWQPQDFLPDPASDGFEDQVRELRERARELPDDYFVVLVGDMITEEALPTYQTMLNTLDGVRDETGASPTSWAIWTRAWTAEENRHGDLLNKYLYLSGRVDMRQIEKTIQYLIGSGMDPRTENNPYLGFIYTSFQERATFISHGNTARQAKEHGDIKLAQICGTIAADEKRHETAYTKIVEKLFEIDPDGTVMAFADMMRKKISMPAHLMYDGRNDNLFDNFSSVAQRLGVYTAKDYADILEFLVGRWKIQDLTGLSGEGNKAQDYLCGLAPRIKRLDERAQARAKKGPKIPFSWIHDREVQL
Protein: Succinyl-CoA--L-malate CoA-transferase beta subunit (EC 2.8.3.22) (Q1KLK0)
Organism: Chloroflexus aurantiacus
Function: Involved in the 3-hydroxypropionate cycle used for autotrophic carbon dioxide fixation. Catalyzes the transfer of CoA moiety from succinyl-CoA to L-malate to yield L-malyl-CoA. It is highly specific for succinyl-CoA as the CoA donor, however it can accept L-citramalate instead of L-malate as the CoA acceptor.
Interaction partners:
Sequence:
MDGTTTTLPLAGIRVIDAATVIAAPFCATLLGEFGADVLKVEHPIGGDALRRFGTPTARGDTLTWLSESRNKRSVTLNLQHPEGARVFKELIAHSDVLCENFRPGTLEKWGLGWDVLSKINPRLIMLRVTGYGQTGPYRDRPGFARIAHAVGGIAYLAGMPKGTPVTPGSTTLADYMTGLYGCIGVLLALRHREQTGRGQYIDAALYESVFRCSDELVPAYGMYRKVRERHGSHYNEFACPHGHFQTKDGKWVAISCATDKLFARLANAMGRPELASSSVYGDQKVRLAHASDVNEIVRDWCSSLTRAEVLERCYATATPAAPLNDIADFFGDRHVHARRNLVAIDAEDLGETLIMPNVVPKLSETPGSIRSLGPKLGEHTEEVLKEILGMCDEQINDLRSKRVI
Protein: Inactive casein kinase II subunit alpha-2 (OsCKA2) (Protein HEADING DATE 6) (Q9AQU1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: The Nipponbare allele of HD6 contains a premature stop codon, resulting in a truncated non-functional product.
Interaction partners:
- Casein kinase II subunit beta
- Casein kinase II subunit beta
- Os07g0295200 protein
- Os02g0728700 protein
- Os12g0166500 protein
- FACT complex subunit SSRP1-A
- FACT complex subunit SSRP1-B
- Oryzain alpha chain
- Oryzain beta chain
- Os05g0508300 protein
Sequence:
MSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIV
Protein: Protein jagged-1a (Jagged1) (Jagged1a) (Q90Y57)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P78504}.
Interaction partners:
- Neurogenic locus notch homolog protein 1
- Notch receptor 1b.
- Notch receptor 3.
- Neurogenic locus notch homolog protein 2 precursor
- Hairy/enhancer-of-split related with YRPW motif protein 1
- Delta-like protein
- Protein jagged-1b
- Recombination signal-binding protein for immunoglobulin kappa J region a.
- Hairy/enhancer-of-split related with YRPW motif protein 2
- Mastermind-like transcriptional coactivator 1.
Sequence:
MILRPSATFAALSAHVLLRCLWMRVCEASGHFEMQVLSMQNVNGELQSGACCDGARDPAERSCAADQCDTFFRVCLKEYQSRVSSGGPCSYGSGSTPVIGGNTFSVKPLDQTNDKTRIVLPFSFAWPRSYTLIVEALDFNNDSSTGSINGQVIEKAVQSGMINPNRQWQVLKHNGPVAQFQYQIRVTCDEHYFGFGCNKFCRPRDDFFGHYTCDHNGNKTCLEGWAGPECNTAICKQGCSIEHGSCKVPGNCRCLYGWQGEYCDQCIPHPGCVHGTCIEPWQCLCDTNWGGQLCDKDLNTCGTLQPCLNGGTCSNTGPDKYHCACPDGYSGQNCERADNACLSEPCLNGGLCVESSLGFECQCAAGWTGPSCNINEDDCSPNPCNHSGVCVDLVDGFKCICPVQWTGKTCLIDANECEESPCVNAHSCRNLIGGYFCECLPGWTGQNCDINVNDCHGQCLNGGLCKDLVNGYRCVCAAGFAGDRCERDVDECASRPCLNGGRCQDTLNGFQCLCPPGFSGATCQLDLDYCESGPCQNGAQCFSLASDYYCKCPEDYEGKNCSQLKDHCLITPCQVIDSCTVAVVSNSTPGGLRLISSSVCGPHGRCRSHSHAGGHFSCDCQDGFTGTYCHENINDCESSPCLSGGTCIDKINAYQCICADGWEGPNCETNIDDCRTNPCRDRGVCRDLVNDFYCECENGWKGKTCHSRESQCDEDTCNNGGTCSDEGDSFKCLCSPGWEGATCNIAKNSSCLPNPCENGATCVVTGDGFTCVCKEGWEGPTCSQNSNDCNPQPCYNSGTCVDGDNWYRCECASGFAGPDCRININECQSSPCAFGSTCVDEINGYRCLCPPGRTGPRCQEVTGRPCVIGGRIAVDGAKWAEDCNTCYCHKGIVTCTKLFCGPKACRMLGSGRGDCPTGQLCVPVRDEQCFVKPCSSQGECWSAHRPAVRTHCQPDSHCANVTFTFNKDTMPQGVTVEQVCRELRHLYVTKNVTSEFSISVSCELSSAASNEIHVAIHVTENGIHGRVPVKEITDNIIDLVSKHSANSSVIGSIAEVRVQRKQPQNPNVDYMVPLLVSVVTAIWVLALASVFLWCIRHHRKQSSSATAINPTSPFSTPEENTANNAREHLNQIKNHIEKNASNGSLPGKELHCDDKNTVNAKIRTQFPESDASRRLQKTRFPHQPAYMLVDRDDRLSSNGTDIKKHPQWTNKRDNRDLESQHRVPDSQHRDSQHSLQKMEYIV
Protein: Suppressor of variegation 2-10, isoform I (A1Z7P5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Small ubiquitin-related modifier
- Dorsal interacting protein 4
- Signal transducer and transcription activator
- SUMO-activating enzyme subunit
- Activator of SUMO 1
- DNA repair protein Rad60
- Uncharacterized protein, isoform C
- DNA topoisomerase 1
- Proliferating cell nuclear antigen
- E3 SUMO-protein ligase NSE2
Sequence:
MRKTRSQTARTQAENAATSSSPGHQSTSSAPIAVNPFDSTKYKECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLELLAPKVQEVYAQSVQEQNATLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSETVDLTLSDSDDDMPLAKRRPPAKQAVASSTSNGSGGGQRAYTPAQQPQQSESPEQQASRQSPEKQTVSEQQLQQQQHEQPATAAVHASLLESLAAAVADQKHFQLLDLAAVAAAAAATASSGQSQNAGP
Protein: Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (P62425)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62424}.
Interaction partners:
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL1
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL2
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein eL42
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein uL4
Sequence:
MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG
Protein: Omega-amidase YafV (EC 3.5.1.3) (Q47679)
Organism: Escherichia coli (strain K12)
Function: Hydrolyzes alpha-ketoglutaramate (a-KGM) to alpha-ketoglutarate (alpha-KG) and ammonia, has weak activity on L-glutamine, almost no activity on deaminated glutathione (dGSH) and none on glutathione (By similarity). May function as a metabolite repair enzyme (By similarity).
Interaction partners:
- NADP-specific glutamate dehydrogenase
- Glutamate synthase large chain
- L-aspartate oxidase
- Glutamate synthase small chain
- Aspartate aminotransferase
- Isocitrate dehydrogenase
- Malate dehydrogenase
- Phosphoenolpyruvate carboxykinase
- 2-oxoglutarate dehydrogenase E1 component
- Citrate synthase
Sequence:
MPGLKITLLQQPLVWMDGPANLRHFDRQLEGITGRDVIVLPEMFTSGFAMEAAASSLAQDDVVNWMTAKAQQCNALIAGSVALQTESGSVNRFLLVEPGGTVHFYDKRHLFRMADEHLHYKAGNARVIVEWRGWRILPLVCYDLRFPVWSRNLNDYDLALYVANWPAPRSLHWQALLTARAIENQAYVAGCNRVGSDGNGCHYRGDSRVINPQGEIIATADAHQATRIDAELSMAALREYREKFPAWQDADEFRLW
Protein: Rifin (Q8IJ04)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHYINILLFVIPLNILINDQRNHKSTTHHTLKIPITRLLCECELYTPANYDNDPQMKEVMDNFNRQTQQRFHEYDERMVEKRMQCKDKCDKEIQKIILKDKLEKELMDKFATLHTDIQSDAIPTCVCEKSVADKMEKGCLRCGSILGAAMPEMGSIGGSLLSALSAWKPVAIEAAEKAAIAKATDLATQAGMREVVLKIEQFLKNFTEKEGLVNFTSVVNKSNFKCPTALFQNANELLSDSCIPDEVTNRTSTFCSTIAYGEKTTFEPFAQAGATTFQETLTAKTPVLQARYTAAVKTAYGGYQTAIIASIVAIVVIVLIMVIIYKILRYRRKKKMKKKLQYIKLLEE
Protein: Fibroblast growth factor 13 (FGF-13) (Fibroblast growth factor homologous factor 2) (FHF-2) (Q92913)
Organism: Homo sapiens (Human)
Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). Regulates voltage-gated sodium channels transport and function. May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity).
Subcellular location: [Isoform 1]: Nucleus {ECO:0000269|PubMed:10644718}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:10644718}. Nucleus {ECO:0000269|PubMed:10644718}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305|PubMed:10644718}. Nucleus {ECO:0000305|PubMed:10644718}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000250|UniProtKB:P61329}. Nucleus {ECO:0000250|UniProtKB:P61329}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000250|UniProtKB:P61329}. Nucleus {ECO:0000250|UniProtKB:P61329}.; SUBCELLULAR LOCATION: Cell projection, filopodium {ECO:0000250|UniProtKB:P70377}. Cell projection, growth cone {ECO:0000250|UniProtKB:P70377}. Cell projection, dendrite {ECO:0000250|UniProtKB:P70377}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P70377}. Cytoplasm {ECO:0000250|UniProtKB:P70377}. Note=Not secreted. Localizes to the lateral membrane and intercalated disks of myocytes. {ECO:0000250|UniProtKB:P70377}.
Interaction partners:
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 3
- Fibroblast growth factor receptor 2
- Sodium channel protein type 5 subunit alpha
- Fibroblast growth factor receptor 4
- Pro-epidermal growth factor
- Fractalkine
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Eotaxin
- Vascular endothelial growth factor receptor 2
Sequence:
MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST
Protein: Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) (P51977)
Organism: Ovis aries (Sheep)
Function: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P00352}. Cell projection, axon {ECO:0000250|UniProtKB:P24549}.
Interaction partners:
- Cytochrome P450 26A1
- Retinol dehydrogenase 10
- Aldehyde dehydrogenase domain-containing protein
- Aldehyde dehydrogenase 1A1
- S-
- Alcohol dehydrogenase-like C-terminal domain-containing protein
- alcohol dehydrogenase
- Dehydrogenase/reductase SDR family member 4
- Cytochrome P450 26B1
- Beta-carotene oxygenase 1
Sequence:
MSSSAMPDVPAPLTNLQFKYTKIFINNEWHSSVSGKKFPVFNPATEEKLCEVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSNAYLMDLGGCIKTLRYCAGWADKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFPLLMFLWKIGPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGVFYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYEKILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTIKISQKNS