wanglab/gogpt-training-data huggingface dataset:
Protein: HTH-type transcriptional regulator PtxR (Pseudomonas exotoxin A regulator) (P72131)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Plays an important role in the regulation of the production of the virulence factor exotoxin A (toxA), via positive regulation of the transcription of the toxA gene. Acts by binding directly to the toxA promoter region. Besides toxA, PtxR modulates the expression of genes that code for the QS-controlled virulence factors. It negatively regulates the expression of the rhamnolipid and pyocyanine genes, through the autoinducer synthase RhlI, and the PQS synthesis operon pqsABCDE, while it positively regulates the expression of lasB through the autoinducer synthase LasI. Also positively regulates the expression of the exotoxin A regulatory protein (toxR or regA).
Interaction partners:
- HTH-type transcriptional regulator PtxS
- Exotoxin A
- Exotoxin A regulatory protein
- Probable transcriptional regulator
- Probable transcriptional regulator
- Sigma factor PvdS
- Probable transcriptional regulator
- cAMP-activated global transcriptional regulator Vfr
Sequence:
MSAALERLNHLNLNHLYAFVAVAEHNSFTAAAEALGLSKSLLSEQLRRLEADLGIQLLTRTTRRMTLTDRGELLFGVAQRMLGELDGALSDVRDLQGEPSGRLRITAPQDFVKWHISSVSAAFIRQFPKVQVEMLADDQFSDLVGQRIDLAVRIGWPRDSGLHASKLCDFQQVAVATPGYLAGLPPVLQPHDLARCEWIGHTRLSTPWTWTFERQRERATVQTRGRLLANNTLAVYRLVLDGAGVSVLPSFLVAREIARGRLVRLLPGWRLPQGGIYALYPSARYMPVRVRAFIESLREHLGREPFRLAQSE
Protein: Calmodulin-2 (P0DP27)
Organism: Mus musculus (Mouse)
Function: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.
Subcellular location: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. {ECO:0000250}.
Interaction partners:
Sequence:
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Protein: Copper homeostasis protein cutC homolog (Q9NTM9)
Organism: Homo sapiens (Human)
Function: May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16182249}. Nucleus {ECO:0000269|PubMed:16182249}. Note=The overexpressed protein is detected in the cytoplasm, and depending on the cell line, also in the nucleus.
Interaction partners:
- Protein CutA
Sequence:
MKRQGASSERKRARIPSGKAGAANGFLMEVCVDSVESAVNAERGGADRIELCSGLSEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREIEVMKADIRLAKLYGADGLVFGALTEDGHIDKELCMSLMAICRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIKRLIEQAKGRIVVMPGGGITDRNLQRILEGSGATEFHCSARSTRDSGMKFRNSSVAMGASLSCSEYSLKVTDVTKVRTLNAIAKNILV
Protein: Protein BEX4 (BEX1-like protein 1) (Brain-expressed X-linked protein 4) (Nerve growth factor receptor-associated protein 3) (Q9NWD9)
Organism: Homo sapiens (Human)
Function: May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability.
Subcellular location: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:27512957}. Nucleus {ECO:0000269|PubMed:27512957}. Cytoplasm {ECO:0000269|PubMed:27512957}. Note=Also localizes to microtubules. {ECO:0000269|PubMed:27512957}.
Interaction partners:
Sequence:
MESKEELAANNLNGENAQQENEGGEQAPTQNEEESRHLGGGEGQKPGGNIRRGRVRRLVPNFRWAIPNRHIEHNEARDDVERFVGQMMEIKRKTREQQMRHYMRFQTPEPDNHYDFCLIP
Protein: Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1) (Q8WVJ9)
Organism: Homo sapiens (Human)
Function: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11062344}. Cytoplasm {ECO:0000269|PubMed:11062344}. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
Interaction partners:
- Runt-related transcription factor 2
- Twist-related protein 1
- CD44 antigen
- Transcription factor E2-alpha
- Zinc finger protein SNAI1
- Zinc finger protein SNAI2
- Zinc finger E-box-binding homeobox 1
- Zinc finger E-box-binding homeobox 2
- Transcription factor 12
- Transcription factor 4
Sequence:
MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
Protein: SH3 and PX domain-containing protein 2A (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) (O89032)
Organism: Mus musculus (Mouse)
Function: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide (By similarity).
Subcellular location: Cytoplasm. Cell projection, podosome {ECO:0000250}. Note=Cytoplasmic in normal cells and localizes to podosomes in Src-transformed cells. {ECO:0000250}.
Interaction partners:
- Actin nucleation-promoting factor WASL
- Src substrate cortactin
- Hematopoietic lineage cell-specific protein
- Growth factor receptor-bound protein 2
- Actin nucleation-promoting factor WAS
- Disintegrin and metalloproteinase domain-containing protein 12
- Proto-oncogene tyrosine-protein kinase Src
- Cofilin-2
- Cofilin-1
- Cytochrome b-245 light chain
Sequence:
MLAYCVQDATVVDVEKRRSPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADTNAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKEAPAEGEGSEAPITKKEISLPILCNASNGSALAIPERTTSKLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEENPVGACESQGSPLKVKYEEPEYDVPAFGFDSEPEMNEEPSGDRGSGDKHPAQPRRISPASSLQRAHFKVGESSEDVALEEETIYENEGFRPYTEDTLSARGSSGDSDSPGSSSLSLAVKNSPKSDSPKSSSLLKLKAEKNAQAELGKNQSNISFSSSVTISTTCSSSSSSSSLSKNNGDLKPRSASDAGIRDTPKVGTKKDPDVKAGLASCARAKPSVRPKPVLNRAESQSQEKMDISSLRRQLRPTGQLRGGLKGSRSEDSELPPQMASEGSRRGSADIIPLTATTPPCVPKKEWEGQGATYVTCSAYQKVQDSEISFPEGAEVHVLEKAESGWWYVRFGELEGWAPSHYLVAEENQQPDTASKEGDTGKSSQNEGKSDSLEKIEKRVQALNTVNQSKRATPPIPSKPPGGFGKTSGTVAVKMRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDSLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSESPLLPTQRKGIPVSPVRPKPIEKSQFIHNNLKDVYISIADYEGDEETAGFQEGVSMEVLEKNPNGWWYCQILDEVKPFKGWVPSNYLEKKN
Protein: Mannitol 2-dehydrogenase (M2DH) (MDH) (EC 1.1.1.67) (Q4WQY4)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway. Has a preference for NADH over NADPH.
Interaction partners:
- Zinc-dependent alcohol dehydrogenase, putative
- Probable D-xylulose reductase A
- L-arabinitol 4-dehydrogenase
- D-xylulose reductase
- D-xylulose reductase
- Probable D-xylulose reductase A
- Exoinulinase InuD
- Phosphotransferase
- Phosphotransferase
- Phosphotransferase
Sequence:
MAPLKLNSRNLSQIAAAGGALVKIPTYQRGRAVKEGIVHIGVGGFHRAHLAVYIDQLMQKHGVNDYAICGVGLQPFDSAMRDALASQDHLYTLIERSAKGSFAHVIGSINSYLFAPDNREAVIAKMAHPDTKIVSLTITESGYYYNENTHELQSEHPDIQFDLDPANEKAPRTTFGFLYAGLTRRYQQGLKPFTVMSCDNMQKNGSITRHMLESFARLRNPEVAEWIAEEGAFPNAMVDRITPQTSETDKTALAEKFGIVDSWPVVTEPFTQWVIEDQFSDGRPPFEKVGVQVVKDVHAVEQFEKHKLRLLNGSHSALGYPGQLAGFQYVHEVMANPLFRKFVWQMMQEEVKPLLPEIPGVDIDEYCNTLIERFTNPTIMDQLPRICLNASGKIPQFIMPSIAEAIWETGPFRRLCFVAAAWFHYIKGVDDRGKPFEVVDPMREELQAKARAGGNDPSELLSIKSLFGDDLRNDERFLREITTAMNDIARDGIMKTLPKYIN
Protein: Mitochondrial pyruvate carrier 3 (Protein NEGATIVE REGULATOR OF GUARD CELL ABA SIGNALING 1) (Q8LD38)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the uptake of pyruvate into mitochondria. Negatively regulates ABA-induced guard cell signaling and mediates drought stress responses.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24842572}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P53157}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitochondrial pyruvate carrier 1
Sequence:
MATSKLQALWNHPAGPKTIHFWAPTFKWGISIANIADFQKPPETLSYPQQIVITGTGLVWSRYSTVITPKNWNLFSVSLGMAVTGIYQLTRKIKHDYVYEANSIVAKE
Protein: O-methyltransferase GliM-like, putative (EC 2.-.-.-) (Q4WYG1)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
Sequence:
MENELEHLNWNIKHALLQLEGPLAQELDSCLEVSPGALSPSNSVYQKILDTVQVLDKLLVTLTPPHMTLVDGVFAFTNSKVLLCASEYALADHVQKLQPCSISQLAEATGLHEQGLFQIVRYLREMGYFSQDPKTGLLSNNRLSNLLRKDHWATWINWVDFFPREYYDLLSRLPDQLRSDQPKTATELFYNTDKPIYQYLAETGRAAGFHKVTGTGSVVEAPGLLADYPWEEVKSETVVDVGAGVGDFIRSYLEKFPDATAAAFELPSTAEILKQRFPDDDPLTSRIVSITGGDFFQDPIPESSVYLLRWILHNWGDEDCIKLLRRIRETMVIKPGVSRVLIIESVLFDGRLGRGARYADIRMLARCRNKERTLGEYRKLAEEAGWRLNRVVSPRGCLTQIMELRPVGACTGSPRANGNGNSAGGLEWESELM
Protein: Ubiquitin-conjugating enzyme E2K (D3ZXS8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Polyubiquitin-C
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-like modifier-activating enzyme 1
- Ubiquitin-like modifier-activating enzyme 6
- Ubiquitin conjugating enzyme E2 V1 like 1
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-like modifier activating enzyme 7
- Huntingtin
- E3 ubiquitin-protein ligase TRIP12
- Small ubiquitin-related modifier 1
Sequence:
MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLSN
Protein: Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) (ADP-glucose pyrophosphorylase) (ADPGlc PPase) (ADP-glucose synthase) (P0A6V1)
Organism: Escherichia coli (strain K12)
Function: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
Interaction partners:
- Glycogen debranching enzyme
- Glycogen synthase
- Glycogen phosphorylase
- 1,4-alpha-glucan branching enzyme GlgB
- Maltodextrin phosphorylase
- 4-alpha-glucanotransferase
- Phosphoglucomutase
- UTP--glucose-1-phosphate uridylyltransferase
- Trehalose-6-phosphate synthase
- UTP--glucose-1-phosphate uridylyltransferase
Sequence:
MVSLEKNDHLMLARQLPLKSVALILAGGRGTRLKDLTNKRAKPAVHFGGKFRIIDFALSNCINSGIRRMGVITQYQSHTLVQHIQRGWSFFNEEMNEFVDLLPAQQRMKGENWYRGTADAVTQNLDIIRRYKAEYVVILAGDHIYKQDYSRMLIDHVEKGARCTVACMPVPIEEASAFGVMAVDENDKIIEFVEKPANPPSMPNDPSKSLASMGIYVFDADYLYELLEEDDRDENSSHDFGKDLIPKITEAGLAYAHPFPLSCVQSDPDAEPYWRDVGTLEAYWKANLDLASVVPELDMYDRNWPIRTYNESLPPAKFVQDRSGSHGMTLNSLVSGGCVISGSVVVQSVLFSRVRVNSFCNIDSAVLLPEVWVGRSCRLRRCVIDRACVIPEGMVIGENAEEDARRFYRSEEGIVLVTREMLRKLGHKQER
Protein: Guanine nucleotide-binding protein subunit gamma-1 (P38040)
Organism: Drosophila melanogaster (Fruit fly)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta-1
- G protein alpha o subunit subunit alpha 47A)
- G protein alpha s subunit subunit alpha)
- Guanine nucleotide-binding protein subunit beta-2
- Guanine nucleotide-binding protein subunit gamma-e
- G protein beta subunit 5
- Guanine nucleotide-binding protein subunit alpha homolog
- G protein alpha q subunit subunit alpha)
- G protein alpha i subunit subunit alpha 65A)
- Guanine nucleotide-binding protein G
Sequence:
MDVMSSSLQQQRVVVEQLRREAAIDRQTISESCAKMMKYITEHEQEDYLLTGFTSQKVNPFREKSSCTVL
Protein: Gdap1, isoform A (RE69232p) (Q9VRJ3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Mitochondrial fission 1 protein
- Transport and Golgi organization protein 11
- Transmembrane GTPase Marf
- dynamin GTPase
- Transmembrane GTPase fzo
Sequence:
MSEQTKEIEALPPTLQDFKAPDLPANKPVLFFHPYNFHAQKVLMVFYEKKIDFFPYVVDLCNGEQYSNWFLNLNPKGDVPVLQDGALVIPSSTHIINYVESKFRGDRSLKPAHNSKEFDQMLIFEQAMARLPVGTLSLGSFIHDDLKLVPKAPFIGPVRQSCLKNNEKVLDLLRHSVDEQATKKAALQHKLDIQLRRHELASSREEFQKVLDAVRHFLLYVEQELTAQAPRVEWLTGDELSVADISLGLLLHRLYQLGFENQFWTFGKLPQVEAYFLRFRQRESFHRLQPSNFAILREMWTRTPGNYKLGAGAGFLGMAMFAAFAHK
Protein: Glycerophosphocholine acyltransferase 1 (GPCAT) (EC 2.3.1.-) (Q9FJB4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA. Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA. In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC. Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- very-long-chain 3-oxoacyl-CoA synthase
- 14.7 kDa heat shock-like protein
- PI-PLC X domain-containing protein At5g67130
- AT4g33900 family protein)
- At1g13195
- Extracellular ligand-gated ion channel protein
- AT5g37540/mpa22_p_70
- Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC
- 1,4-dihydroxy-2-naphthoyl-CoA thioesterase 1
- Phosphate transporter PHO1 homolog 5
Sequence:
MANNEDSNSNGLDSFDAVKQRFKDRSKKVVQTRELLSKQAVQTREILSKQAVKIAKQAEEHERFINKVTHLVGVLGFGGFCFLLGARPQDIPLVYCFFYVIFVPLRWIYYRFKKWHYYLLDFCYYANTIFLVDLLLYPKNEKLFMVCFSFAEGPLAWAIIVWRCSLVFSSPDKIVSVLIHLLPGLVFFTIRWWNPATFAAMHPVGTDRRVSWPYVEDKAYLFTWLFLVPLVVYTLWQVLYFLIVNVLRRQRLLRDPEVMTSYRELSKKAEKANNKLWQLSGLLGDQNRIWMYILFQAIFTVATMALTVPIFLSYRLHVIFQILKISAAVWNGGSFLLEVMPRQVIQKEKKKKAEMQPIEEQILHHEAVSHPTENEPKSTET
Protein: NLR family CARD domain containing 5 (H0YGE2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAGLFSLRDSTRHTEKLSFPTLEACALGFKKKRKKERKKVSEDTELRTKIN
Protein: Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) (Q8CIQ7)
Organism: Mus musculus (Mouse)
Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10854253}.
Interaction partners:
- Enhancer of filamentation 1
- Engulfment and cell motility protein 2
- Rho-related GTP-binding protein RhoG
- Ras-related C3 botulinum toxin substrate 1
- Engulfment and cell motility protein 1
- Cell division control protein 42 homolog
- Tyrosine-protein kinase Fyn
- Engulfment and cell motility protein 3
- Adapter molecule crk
Sequence:
MWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGLFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTTTLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPYHFFFSLKSFTYNTIGEDSDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPAHLHYRRPYGCAVLSILDVLQSLTELKEEKDFVLKVYTCNNESEWTQIHENIIRKSSTKYSAPSASHGLIISLQLFRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGHCPVTAEITGEYVSCLLSLLRQMCDTHFQHLLDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFGLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKVGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIRKMEASYYDNIIEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQMDRVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKDNEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYITKHPGDAEKISQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPENIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNMMMMGDNSMGEAPEDLYHHMQLAYHNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSTRGSPSLPDKYRHAREMMLLLPTHRDRPSSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPNLSMAEKGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEAPPRTDTMDSMPSQAWNGDEGLEPPYLPVHYSLSESAVLDAIKSQPCRSHSAPGCVLPQDPMDPPALPPKPYHPRLPALEHDEGMLLREEAERPRGLHRKASLPPGSVKEEQARLAWEHGRGEQ
Protein: Protein fuzzy homolog (Q9BT04)
Organism: Homo sapiens (Human)
Function: Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q2HZX7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2HZX7}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q3UYI6}.
Interaction partners:
- Protein inturned
- WD repeat-containing and planar cell polarity effector protein fritz homolog
- Ciliogenesis and planar polarity effector 2
Sequence:
MGEEGTGGTVHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSARTENTTVVWKSFHDSITLIVLSSEVGISELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVSLVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLCGPSPPLSQLYPQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDKEPSPEQRRRLLRNFYTLVTSTHFPPEPGPPEKTEDEVYQAQLPRACYLVLGTEEPGTGVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHALTPLL
Protein: Fgr28p (A0A1D8PLX8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Fgr14p
Sequence:
MKGIEQLNMYPKSIYIYDMEQFQYEQNTLIEVLKKSPGTHACFSQSSDSDSETMSKFYINSNVKFDHLELSYFSNPLTLPLIATSIKLHGTRLNNYAIPGVKKLSLFQNSSGDRDQIYTFSSDLEDLYISARESIQVTLPPNLRKLSISAGPSSVDLVSEEMVNLEYFSLMFPNIQSFSETGIIAPNLKNLVLIHCHISNYDGLKQFQHLKDLELKCLSFPMSLFNDGCLPELESFTCKECLIHNTGDFDKSLSIFPPNLKTLELETCKFVNTEFSNWVLSDTLEILRISDSPFKDGFLGEYLKDVDVSGNELTLDSNFRIFHMVEEFTLYPYYLTFESSDFMYHLPNNILRLHLISNGEGKMSPLTQMVKWPSMLTDFAFRNFNIDNQTLELLNMKESNLEIIKICGGDVKKLFADLFPVSVKDLSLNDMGIQKLPDSFENLENLRSLSLFENQLRKVNSLKLPVSTLQTLNVCRCNLHLISPFLVSMLEEKNKNAELEICAWGNTNISVIDIRTALKSIKGLSLEVDDFDKTLTEISKHSSRLQCKYFVYDPYSKESKSSATEEVALDYDPDDLYDGSDSSLDEEDAGGDIKRRKM
Protein: Agamous-like MADS-box protein AGL3 (Protein SEPALLATA 4) (P29383)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor that binds specifically to the CArG box DNA sequence 5'-CC (A/T)6 GG-3'. Plays an important role in the determination of flower meristem identity. Involved in the specification of sepal identity. Contributes to the development of petals, stamens and carpels.
Subcellular location: Nucleus.
Interaction partners:
- Protein LEAFY
- Floral homeotic protein APETALA 2
- MADS-box protein
- Protein TERMINAL FLOWER 1
Sequence:
MGRGKVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEIALLIFSNRGKLYEFCSSPSGMARTVDKYRKHSYATMDPNQSAKDLQDKYQDYLKLKSRVEILQHSQRHLLGEELSEMDVNELEHLERQVDASLRQIRSTKARSMLDQLSDLKTKEEMLLETNRDLRRKLEDSDAALTQSFWGSSAAEQQQQHQQQQQGMSSYQSNPPIQEAGFFKPLQGNVALQMSSHYNHNPANATNSATTSQNVNGFFPGWMV
Protein: Integrin subunit beta 1 binding protein 2 (D3ZW59)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Integrin beta-1
- Fat storage-inducing transmembrane protein 1
- Protein SGT1 homolog
Sequence:
MSLLCYNKGCGQHFDPNTNLPDSCRYHPGVPIFHDALKGWSCCRKRTVDFSEFLNIKGCTVGPHCAEKLPEVPQPEGPATSSLQEQKPLNTIPKSAETLLRERPKSEMPPKLLPLLISQALGVALEQKELDQEPGAGLDNSLIWTGSSCQNPGCDAVYQGPESDATPCTYHPGAPRFHEGMKSWSCCGIQTLDFGAFLAQPGCRVGRHDWAKQLPASCRHDWHQTDSLVVLTVYGQIPLPAFNWVKASQTELHVHIVFDGNRVFQAQMKLWGVINVEQSSVSLMPSRVEISLVKADPGSWAQLEHPDSLAEKARAGVLLEMDEEESEDSDDDLSWTEEEDEDEEEAMGE