wanglab/gogpt-training-data huggingface dataset:
Protein: MGC68806 protein (Protein tyrosine kinase 7 (Inactive) L homeolog precursor (EC 2.7.10.1)) (Q6PA07)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MGPIVLSAFILLVVVSTRAAILFTKEPYSQDALHGRSAILRCEVEEPVEVQFEWLQNGVPVRDTERRYQEGGSLTFTAVDRKQDGGTFQCVARNPNTGEEGRSNIAYFNIKWIESGGVTLQYPGSASDIQSSSRVILRCHIDGHPRPICLWFRDGTPLADDGQAISLSNRERTLTLHSAGPDDSGEYYCCAYNAAGSVCSNRNFTLSIIDESFPQAVVIPEDQVVNKNEDAMFHCLFSATPPPSQEWFFEDQVPLSNKSRITVFQNGSLLISSVRPRSSGVYSCVGTGYRGQKAVLKASLRLADIDKMRPLPPRVLTADMVQRITCDGPQGIPPPTVWWERDGTRVPAEGRVYQDGMELVFKPITEGDSGSYICHAANKAGERRQELQITVATVPEWLERPTDSLMEEGKPGFLHCQSKASLEPNITWYRNGNPVSKDSRFEVFPNGTLKILHVEVYDGTVYRCVSSTPAGYIDAQARVHVQENLKFTPIPRPHQCMELDKEMTVHCSATGREKPNIQWIKGDGSDLPGHVESKAGLLHFQPVTRRDAGNYTCIASNSLQGEIQAAVHLTVAVLVSFKIEPENTTVYQGHTAVLHCQAEGDPTPNIQWQSRDVMVAAKHYPRIQVMPNGSLVIYRVTNEDAGKYACIAGNACDIKHRDTFLYVVDKPPGGANEPDSPYKLIQTIVLSVVAAVTYIIIVLGLMLYCKKRRKARRHGKHEGDEPEMECLNGDALLQNGQTTAEIPEEVPLTTLSNKRHSSGDKISFPRANLHPITTLGRGEFGEVFLAKAPNPDSTSGEAVVLVKALQTRDEQLQMDFRRELDMFSKLNHANVVRLVGQCREAEPHYMVLEYIDLGDLKQFLRISRSREEKPKPLSSKHKVSLCTQVALGMEHLSNSRFVHKDLAARNCLVSAQRLVKVSALGLSKDVYSSEYHPLRQTKVPLRWMSPEAVQDDDFSTKSDVWSFGVLMWEVFTLGELPYTSLPDEEVLAGLQNGSLKLPAPEGCSSRVYRLMQRCWAPSPKDRPSFSEIVNALGDLSSGSKTQG
Protein: Nebulin (Q9DEH4)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
DHEKQKGHYVGVPNAKADTKIRFALGIGKVQSELEYKKHFAKWKTQCHLPVDMLSIQSAKHGQSLVSDVDYRHYLHQWICLPDQNDVIHARKAYDLQSDAVYKSDLEWLRGIGWLPNDSLGINHVKHAGDLLNERKYRTKAETLHFTPVADRVDYVTAKKSGEILSDIKYHKDWNEVKSNYTLTDTPQLDMAREAARILNQSLYKESWEKEKATGYLLPPDTVQIRHAKHSNDVQSELKYKADYVKQRGHYVGVASMRDDPKLVWFEHAGEIQNDRLYKSNYHKTKSKIHIPADIMSVVAAKECQALVSDVDYRHYLHQWTCHPDQNDCIQARKAYDLQSDNIYKSDLEWLRGCGWIPLGSVEHKKVKHAQELINKRAYTKDAIENFSKYTSVVDTPDIVLAKINSVNQSDLKYKETFNLEKGQYIGSDDTPELNHARDMSLLYSDKLYKRDWEVCKPIGYTLDAKYIPLVGAKHANYVNSELKYKEIYEKLKGHYLAGKDIGDFPSVVHSLAFQKIRSALAYRKNYEDTKTRVHIPSDMMNHVLAKKCQYILSDLEYRTYLHHWNCSPEEHDVIQARRAQEILSDVVYKDDLNWLKGIGCYVWDTPQILHAKKSYDLQSQIKYTAAGKENFQNFGVVTDTPVYVTAVQSGINASDVKYKEDYHKTKDKYTTVTETADSERVQNLKHLFSNNLYKEAWDRVKATSYIMPSDAVSLARAKELKHNASIVKYREEYDKFKALYTLPRSVEDDPNTARCLRVGKLNIDRLYKETYEKNKAKVHIIPDMVDIIAAKDAQKKISEIDYRTHLHDWICLPDLQINAHVRKVADQISDVVYKDDLNWLKGIGCFVWDTPEILHAKHAYDLRSDIKYKSDADKMKSKYTVVMDTPVYVQNILSGLNASEVIYRGDYLKKVRGKMIPTDKTVDLQRAHHANKIQSENLYRWAGLKALPTGYSLPKDTPGFQHAKHVQHIGSDLKYKEAYEHMKAKGYTLGPNDVGFENVKKVNQVINERLYRATYHKNKDKIHTTPDTPEIRQVRATQEAVSDLIYKSDFFKLQGHLISLPFTPQVLHCRYVGDITSDNKYKEDLKWLQGLGCFLYDTPDMVRARQLRKLWSNYVYTDSAKKMRDKYSVVLDTPGYRTVQELKTHLSDLVYRAAGKELKTKYTSVLNTPDFLRAKEGQRIQSQYLYVALATKERPHHHAGNQTPAFTHARHVKDMVSETKYKIQYEKMKDKYTPVLDTPILIRAKRAYLNASDLRYKETFENTKGKYHTVKDALDIVYHRKVTDDISSVKYKENYMSQLGIWRSIPDRPEHFHHRAVTDAISDVKYKEDLSWLRGIGCYAWDTPDFALAEKNKVLYSGHKYKETFEKTKSHFKYVADSPINRHFKHATQLLDANSYKSLAKMLLKQGCNEILRPDILTALYNSYLWSQVEYKKDYEKKKDKYTTVVDTPENIRTAKVNKQISDIIYKLEYNKAKPKGYTTIHDTPMLLHVRKVKDRISDLKYKELYERNKSHCNVVADSVHIKTPRHAYKLNSNLDYKKKYEAAKAHWHWIADRPDFVQAAKSSLQQSDYEYKLDREYLKGCKLSVTDDKNTVLALNNAILASDIKYKEKHNKARGTCLVVPDTPQILLAKNVSSLVSENKYKEHSKKQLPRGSYTTLPETRDTAHVKEVTKNVSDTNYKKKFVKEKGKSNYSIMLEPPEVKHAMEVAKKQSTVEYKKDAKSKLHYTPIADRPDIKKATQAAKLISDIEYKKRGEAGLGVTMLGRPDIELAKEVSKLTSQVKYKENFSKEKGKKPKYDLKEAKIYKTMKDAHNIASEVKYKADLKKLHKPVTDMSESLIMNHVLNTSQLASAVKYKEKYEKEKGKPMLDFETPTYLTAKESQLMQSEKEYRKDLEEGVKGKGLSVLEETPDMLRAKNATQILNEKEYKKALELEIKGKGLSELALETPDFVRAKNATDIASQIKYKQLAEMEKANYTSVVDTPEIIHAQQVKNLSSQKKYKEEAEKTMPYYVPVADTPEMQRVRENQKNFSTLQYQWDLQNSKGKVTVVQDTPEMLRVKENQKNFSSIKYKESIGKGTPIPDLPEVKRVKETQKHISSVLYKEHLAKGTPTPMTPEMERAKRNQENISSVLYSDSFRKQVQGKAAYVLDTPEMRRVRETQKHISTVKYHEDFEKNKGTFTPVVTDPITERVKKNMHDFSDISYRGIQRRVVEMEQKRVDQDQENLTGLRVWRTNPGSVFDYDPAEDNIQSRSLHMISVQAQRRSREHSRSASALSISGGDEKSEPSEGVNQHLSYYSSGGFFTTTATVGYKHAKTIELPQQRSASVATQQTTVSSVPSHPSTAGKTYRAMYDYTAADADEVSFKDGDTIVNVQAIDEGWMYGTVQRTGKTGMLPANYVEAV
Protein: Acyl-CoA thioesterase II (EC 3.1.2.-) (O06209)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MSIEEILDLEQLEVNIYRGSVFSPESGFLQRTFGGHVAGQSLVSAVRTVDPRYMVHSLHGYFLRPGDAKERTVFLVERIRDGGSFCTRRVNAVQHGETIFSMAASFQTEQEGITHQDVMPAAPPPDGLPGLNSIKVFDDAGFRQFDEWDVCIVPRERLRLLPGKASQQQVWLRHRDPLPDDPVLHICALAYMSDLTLLGSAQVNHLDVRDQLQVASLDHAMWFMRPFRADEWLLYDQSSPSASGGRALTRGEIFTRSGEMVAAVMQEGLTRHRRGHRSVGQ
Protein: Obg-like ATPase 1 (EC 3.6.5.-) (Ribosome-binding ATPase YchF) (OsYchF1) (Q6Z1J6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP (Potential). Exhibits GTPase activity. Exhibits similar binding affinities and hydrolytic activities toward both GTP and ATP. Binds to the 26 S ribosomal RNA in vitro, but not to the 5.8 S or 18 S rRNA. Confers sensitivity to salinity stress by suppressing the anti-oxidation enzymatic activities and increasing lipid peroxidation thus leading to the accumulation of reactive oxygen species (ROS).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20876569, ECO:0000269|PubMed:23550829}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03167}. Cytoplasm, cytosol {ECO:0000269|PubMed:20876569, ECO:0000269|PubMed:23550829}. Note=Localized mainly in the cytosol under NaCl treatment, but translocates to the plasma membrane upon wounding. {ECO:0000269|PubMed:20876569, ECO:0000269|PubMed:23550829}.
Interaction partners:
- Adenylosuccinate lyase
- Thymidylate kinase
- Inosine triphosphate pyrophosphatase
- Guanylate kinase 2, chloroplastic/mitochondrial
- Guanylate kinase 1
- Adenylate kinase isoenzyme 6 homolog
- Os04g0559200 protein
- Ribonucleoside-diphosphate reductase
- Ribonucleoside-diphosphate reductase
- Peptidyl-tRNA hydrolase, mitochondrial
Sequence:
MPPKASKKDAAPAERPILGRFSSHLKIGIVGLPNVGKSTFFNIVTKLSIPAENFPFCTIDPNEARVYVPDERFDWLCQLYKPKSEVSAYLEINDIAGLVRGAHAGEGLGNAFLSHIRAVDGIFHVLRAFEDKEVTHIDDSVDPVRDLETIGEELRLKDIEFVQNKIDDLEKSMKRSNDKQLKLEHELCEKVKAHLEDGKDVRFGDWKSADIEILNTFQLLTAKPVVYLVNMSEKDYQRKKNKFLPKIHAWVQEHGGETIIPFSCAFERLLADMPPDEAAKYCAENQIASVIPKIIKTGFAAIHLIYFFTAGPDEVKCWQIRRQTKAPQAAGTIHTDFERGFICAEVMKFDDLKELGSESAVKAAGKYRQEGKTYVVQDGDIIFFKFNVSGGGKK
Protein: Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (Protein somitabun) (SMAD family member 5) (SMAD 5) (Smad5) (Q9W7E7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity). {ECO:0000250}.
Interaction partners:
- Mothers against decapentaplegic homolog.
- receptor protein serine/threonine kinase
- receptor protein serine/threonine kinase
- Serine/threonine-protein kinase receptor
- Receptor protein serine/threonine kinase
- SMAD family member 4.
- Mothers against decapentaplegic homolog.
- Mothers against decapentaplegic homolog
- Mothers against decapentaplegic homolog
- Bone morphogenetic protein 2
Sequence:
MTSMSSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEDLEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLEVCEYPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEFNPQHSLLVQFRNLSHNEPHMPLNATFPESFQQHSGGSSFPISPNSPYPPSPASSGTYPNSPASSGPSSPFQLPADTPPPAYMPPDEQMGQDGSQSMETGSSLAPQNMPRGDVQPVEYQEPSHWCSIVYYELNNRVGEAYHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDTSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEVHLHGPLQWLDKVLTQMGSPLNPISSVS
Protein: E3 ubiquitin-protein ligase MARCHF2 (EC 2.3.2.27) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172) (RING-type E3 ubiquitin transferase MARCHF2) (Q99M02)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Ubiquitinates and therefore mediates the degradation of DLG1 (By similarity). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (By similarity). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteosomal degradation. May be involved in endosomal trafficking through interaction with STX6.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9P0N8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Lysosome membrane {ECO:0000250|UniProtKB:Q9P0N8}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q9P0N8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9P0N8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9P0N8}. Cytoplasm {ECO:0000250|UniProtKB:Q9P0N8}. Cell membrane {ECO:0000250|UniProtKB:Q9P0N8}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Syntaxin-6
Sequence:
MTTGDCCHLPGSLCDCSSSPAFSKVVEATGLGPPQYVAQVTSRDGRLLSTVIRALDSQSDCPFCRICHEGANGENLLSPCGCTGTLGAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPRPLTEWLKDPGPRTEKRTLCCDMVCFVFITPLAAISGWLCLRGAQDHLRLHSRLEAVGLIALTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKIREADGSEDPHHSLLATGLLKKVAEETPV
Protein: BHLH transcription factor (Helix-loop-helix DNA-binding domain containing protein, expressed) (Os03g0188400 protein) (cDNA clone:002-130-B03, full insert sequence) (Q8H7N8)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MALEAVVFPQGHFGYGCGRDSPAYGMPWCDVLAAAGGGGGFGEFYGVDEWDDQLQVASVDEWEVASKDNSDASTEGKAAAAERAEPVAAGRRKRRRTKVVKNKEEIECQRMTHIAVERNRRRQMNEYLAVLRSLMPASYSQRGDQASIVGGAINYVKELEQLLQSLEVQKSLKNRSGAMDAAGDSPFAGFFSFPQYSTSPRTGCSAAASAGSSGSASSVVMDDTAGSAESGRQSAAIADIEVTMVEGHASLKVLARRRPKQLLKLVVGLQQLRIPPLHLNVTTVDAMVLYSFSLKVEDDSKLGSVEDIATAVHQILGSIQQQEAVLSIS
Protein: Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) (P13631)
Organism: Homo sapiens (Human)
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:28167758}.
Interaction partners:
- Arginine--tRNA ligase, cytoplasmic
- Retinoic acid receptor RXR-gamma
- Retinoic acid receptor alpha
- Retinoic acid receptor RXR-beta
- Retinoic acid receptor RXR-alpha
- Cellular retinoic acid-binding protein 2
- Retinoic acid receptor beta
- Steroid receptor RNA activator 1
- Nuclear receptor corepressor 1
- Nuclear receptor corepressor 2
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
Protein: Brorin (Brain-specific chordin-like protein) (von Willebrand factor C domain-containing protein 2) (Q2TAL6)
Organism: Homo sapiens (Human)
Function: BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Synapse {ECO:0000250}.
Interaction partners:
- Chordin
Sequence:
MPSSTAMAVGALSSSLLVTCCLMVALCSPSIPLEKLAQAPEQPGQEKREHASRDGPGRVNELGRPARDEGGSGRDWKSKSGRGLAGREPWSKLKQAWVSQGGGAKAGDLQVRPRGDTPQAEALAAAAQDAIGPELAPTPEPPEEYVYPDYRGKGCVDESGFVYAIGEKFAPGPSACPCLCTEEGPLCAQPECPRLHPRCIHVDTSQCCPQCKERKNYCEFRGKTYQTLEEFVVSPCERCRCEANGEVLCTVSACPQTECVDPVYEPDQCCPICKNGPNCFAETAVIPAGREVKTDECTICHCTYEEGTWRIERQAMCTRHECRQM
Protein: Neurogenic differentiation factor (D4A7M5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR015618}.
Interaction partners:
Sequence:
MAKMYMKSKDMVELVNTQSWMDKGLSSQNEMEEQERRPGSYGMLGTLMEEHDSIEEEEEEEEDGDKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTLEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQSALLEKREEKSPICDSTVSVHSFNYQSPGLPSPPYGHMETHPLHLKPQPFKSLGDSFGSHPPDCSTPPYEGPLTPPLSISGNFSLKQEGSPDLEKSYNFMPHYTSASVSSGHVHSTPFQTGTPRYDVPVDLTYDSYPHHGIGTQINTIFSD
Protein: Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Alkylglycerone-phosphate synthase) (P97275)
Organism: Cavia porcellus (Guinea pig)
Function: Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:8399344}. Peroxisome {ECO:0000269|PubMed:9989261}.
Interaction partners:
- Dihydroxyacetone phosphate acyltransferase
- Peroxisomal targeting signal 2 receptor
- (S)-2-hydroxy-acid oxidase
- Peroxisomal targeting signal 1 receptor
- Cytochrome b5 reductase 4
- PEX5-related protein
- Peroxisome biogenesis factor 10
- Bifunctional epoxide hydrolase 2
- Peroxisomal membrane protein PEX14
- Peroxisome assembly protein 12
Sequence:
MAEAAAAAAAAAAAGETSASSGSAAERDPDQDRAGRRLRVLSGHLLGRPQEALSTNECKARRAASAATAAPTATPAAPESGIIPKKRQELMKWNGWGYNDSKFFLNKKGQLELTGKRYPLSGVALPTFKDWIQNTFGINLDHKTTSKASLNPSDTPPSIVNEDFLHELKKTNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWISTRASGMKKNIYGNIEDLVVHMKVVTPRGVIEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIKIRPTPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNQQFQFGHALKPQVSSIFTSFLDGLKKFYITKFKGFDPNQLSVATLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGYLLTYVIAYMRDLGLEYYIIGESFETSAPWDRVVDLCRNVKERIRRECKEKGVQFPPLSTCRVTQTYDAGACIYFYFAFNYRGISDPLAVFEQTEAAAREEILANGGSLSHHHGVGKLRKQWLKESISDVGFGMLKSVKDYVDPTNIFGNRNLL
Protein: Single-stranded DNA-binding protein, mitochondrial (C9K0U8)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00004436}.
Interaction partners:
Sequence:
MFRRPVLQVLRQFVRHESETTTSLVLERSLNRVHLLGRVGQDPVLRQVEGKNPVTIFSLATNEMWRSGDSEVYQLGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYLEGKIDYGEYMD
Protein: Programmed cell death protein 10 (Q6NX65)
Organism: Rattus norvegicus (Rat)
Function: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BUL8}. Golgi apparatus membrane {ECO:0000269|PubMed:20332113}; Peripheral membrane protein {ECO:0000269|PubMed:20332113}; Cytoplasmic side {ECO:0000269|PubMed:20332113}. Cell membrane {ECO:0000269|PubMed:20332113}; Peripheral membrane protein {ECO:0000269|PubMed:20332113}; Cytoplasmic side {ECO:0000269|PubMed:20332113}.
Interaction partners:
- non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase 25
- Striatin
- CCM2 scaffold protein.
- Striatin-3
- Striatin-4
- Serine/threonine-protein kinase 24
- Striatin-interacting protein 1
- Suppressor of IKBKE 1
- Sarcolemmal membrane-associated protein
Sequence:
MTMEEMKTEAEAASMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRLIHQTNLILQTFKTVA
Protein: Lipid droplet-associated hydrolase (EC 3.1.1.13) (Lipid droplet-associated serine hydrolase) (mLDAH) (Q8BVA5)
Organism: Mus musculus (Mouse)
Function: Probable serine lipid hydrolase associated with lipid droplets. Appears to lack cholesterol esterase activity. Appears to lack triglyceride lipase activity. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.
Subcellular location: Lipid droplet {ECO:0000269|PubMed:23525007, ECO:0000269|PubMed:24357060, ECO:0000269|PubMed:28578400}. Endoplasmic reticulum {ECO:0000269|PubMed:23525007}. Note=Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction (PubMed:23525007). Lipid droplet localization does not require hydrolase activity (PubMed:28578400). {ECO:0000269|PubMed:23525007, ECO:0000269|PubMed:28578400}.
Interaction partners:
Sequence:
MASEVEEQIPVREEFFLCGGVETKIIKCGPWTNLFEKQDVSKPKQLIFIIPGNPGYSAFYVPFAKALYTLMKSRFPVWIISHAGFSVTPKDKKVLAAPQEESNAQKIEDVYGLNGQIEHKIAFLRAHVPKDVKLILIGHSVGTYMTLHVMKRVLELPVAHAFLLFPTIERMSESPNGKFATPFLCQFRYLLYATSYLLFKPCPEVIKSFIIQKLMGQMNIKLELPLTDILQPFCLANAAYLGSQEMVQIVKRDDDIIKEFLPKLKFYYGKTDGWCPVKYYEDMKKDFPEGNIYLCEKGIPHAFVLDFSQEMATIVAEWINNRPPRK
Protein: Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) (O88809)
Organism: Mus musculus (Mouse)
Function: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration.
Subcellular location: Cytoplasm {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9ESI7}. Note=Localizes at neurite tips. {ECO:0000250|UniProtKB:Q9ESI7}.
Interaction partners:
- Calcium/calmodulin-dependent protein kinase type 1
- Calcium/calmodulin-dependent protein kinase type 1B
- Calcium/calmodulin-dependent protein kinase type 1D
- RNA binding protein fox-1 homolog 3
- Tubulin beta-3 chain
- Glial fibrillary acidic protein
- Nestin
- Serine/threonine-protein kinase H1
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
- MAP kinase-activated protein kinase 3
Sequence:
MELDFGHFDERDKASRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSAAAGPKASPTPQKTSAKSPGPMRRSKSPADSGNDQDANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKVDLYLPLSLDDSDSLGDSM
Protein: Uncharacterized protein (Q581Y9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Pre-mRNA-processing factor 19
- Uncharacterized protein
- Cell division control protein, putative
- Pre-mRNA-splicing factor SYF1
- PRP8 protein homologue
- G10 protein
- Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein
- U5 small nuclear ribonucleoprotein component, putative
- Pre-mRNA splicing factor, putative
- Splicing factor YJU2
Sequence:
MHIYPQLAHFQYFYSMQDYLREIEGRLARKRERQNTVLYRLAKRKADEKRLSSLGIRSLPSSPLETADVNVVKFVIFKTKQEIGDKVARLRNPELVSIETHGEVVVRAKNDEVNQLISKKNLWERRLATLNGETHRRAAPRKIYFGCAAGLPEAKRDDAKEVVAHVENEEDGWESGSHASSNSDDDDDDAPKPSTLYREELASRGSEDLLRCIETEAERNLRSVYSHGSESSPGRSQMAEETFIVDVVLPTEEEFRIKHLERRKQAIQKRLDALKN
Protein: PAS domain-containing protein tyrosine kinase family protein (Putative serine/threonine kinase) (O82754)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Heat shock protein 90-5, chloroplastic
- AFG1-like ATPase family protein
- At2g24860/F27C12.22
- Melanoma-associated antigen G1-like protein
- At2g17975
- Zinc finger
- T1N15.19
- RHOMBOID-like protein 2
- Protein IQ-DOMAIN 22
Sequence:
MAGNNSESSLYQVLVEWCQRMETSQARLREDVDDLLLQEESRTGKESATGLETDTEKEAEVEVEAEAADSWDNPTATWERAVSGFYFADSAYRTLMDSMGHAIHVTSAASGEITFWSRSAENLYHWYAEEVVGYRTIDVLVTEEYRNSLTGIRNRVCRGETWTGQFPFQKKTGELFMALVTKSPVYENGELVGVVTVSSDATLFNRMHPLSNEHQQQARSNNRHESNLRKHQWHLPRPQIAAASQVPVVPQYSSAVASNLKASKLLPQRNGDDSFNGNHNSRSRDENVPVVASTTFEKYGSLADKFLGKLQRKITGSQGTEDNEPILRNGINKSACGSGGSSKASNAVTCTAFRDNGNGKPKRAEVRISDVYGNGAEGLIHNGDRFQYIGNLGQSKPPRGLESGLVSGMRGTKMSDLNGEIEDAWNTRLSVDPLPILGVNSGRQQSPVNQRNNRLVTDSSCEIRWEDLQLGEEVGRGSFAAVHRGVWNGSDVAIKVYFDGDYNAMTLTECKKEINIMKKLRHPNVLLFMGAVCTEEKSAIIMEYMPRGSLFKILHNTNQPLDKKRRLRMALDVARGMNYLHRRNPPIVHRDLKSSNLLVDKNWNVKVGDFGLSKWKNATFLSTKSGKGTPQWMAPEVLRSEPSNEKCDVFSFGVILWELMTTLVPWDRLNSIQVVGVVGFMDRRLDLPEGLNPRIASIIQDCWQTDPAKRPSFEELISQMMSLFRKPGSGAQEEDD
Protein: RING-type domain-containing protein (Q38AM3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- MRH domain-containing protein
- Protein OS9-like domain-containing protein
- Katanin p60 ATPase-containing subunit A-like 2
- Derlin
- Derlin
- UBX domain-containing protein
Sequence:
MTPLQVLFILLGVAVVAQWNLLLRLPQTVVAAVWLAVMTAVISASWSTMLLVERVCGLCEANAHGQLVNPSSSGTPLRKTVFMALFYPLLLTFSAGVSVTLAWRDSLLLGGVASGCVAFLEQQLEMWPRRRDLKFRVVSCTLCGFALFCTALLWSFHVTSPREESSMGSLAQFAVIMWTAALTTGLLKLLLFATLHAWHTSNVLTGRAGSVDFDPMEEVGLSIRICCSLILLVVSGEHLPNFTGILVHVVVLAPFLDVLYAASILFRFRHVVDSFPEVGTAADCVICFDPVTDSARGRQLRCGHIFHSRCLRRWLMRAARCPTCRQYVFHQENALFPVELFYDFRANIRHRGVGDEDAQRGRRPRELPYAGRSVGVQTPVYQSLFPVGGHAPSRHVAISSSPAVETALGYGVTFADEVAFTPGGPSVRSAASSTREAVIASVHSDEFTDTPIAAVPVVVRQRGVTAATRYKSGGELSVGGGLGERSAVEATNIDGGGREACTVVSTRSGGRGRKRQRDSS
Protein: Capsid vertex component 2 (Q6SW65)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.
Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
Interaction partners:
Sequence:
MSLLHTFWRLPVAVFFEPHEENVLRCPERVLRRLLEDAAVAMRGGGWREDVLMDRVRKRYLRQELRDLGHRVQTYCEDLEGRVSEAEALLNQQCELDEGPSPRTLLQPPCRPRSSSPGTGVAGASAVPHGLYSRHDAITGPVAAPSDAVAASAAAGASSTWLAQCAEQPLPGNVPNYFGITQNDPFIRFHTDFRGEVVNTMFENASTWTFSFGIWYYRLKRGLYTQPRWKRVYHLAQMDNFSISQELLLGVVNALENVTVYPTYDCVLSDLEAAACLLVAYGHALWEGRDPPDSVTAVLSELPQLLPRLADDVSREIAAWEGPVAAGNNYYAYRDSPDLRYYMPLSGGRHYHPGTFDRHVLVRLFHKRGVLQHLPGYGTITEELVQERLSGQVRDDVLSLWSRRLLVGKLGRDVPVFVHEQQYLRSGLTCLAGLLLLWKVTNADSVFAPRTGKFTLADLLGSDAVAGGGLPGGRAGGEEKGYGGRHGRVRNFEFLVQYYIGPWYARDPAVTLSQLFPGLALLAVTESVRSGWDPSRREDSAGGGDGGGAVLMQLSKSNPVADYMFAQSSKQYGDLRRLEVHDALLFHYEHGLGRLLSVTLPRHRVSTLGSSLFNVNDIYELLYFLVLGFLPSVAVL