wanglab/gogpt-training-data huggingface dataset:
Protein: Probable pyridoxal 5'-phosphate synthase subunit PDX2 (AtPDX2) (EC 4.3.3.6) (Protein EMBRYO DEFECTIVE 2407) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) (Q8LAD0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PDX1. Involved in the indirect resistance to singlet oxygen-generating photosensitizers.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16157873}.
Interaction partners:
- Pyridoxal 5'-phosphate synthase subunit PDX1.1
- Pyridoxal 5'-phosphate synthase-like subunit PDX1.2
- Pyridoxal 5'-phosphate synthase subunit PDX1.3
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
- Pyridoxal kinase
- Pyridoxal 5'-phosphate synthase PDX1-like 4
- Probable ribonuclease P/MRP protein subunit POP5
- GDSL esterase/lipase CPRD49
- GDSL esterase/lipase At5g45920
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 2
Sequence:
MTVGVLALQGSFNEHIAALRRLGVQGVEIRKADQLLTVSSLIIPGGESTTMAKLAEYHNLFPALREFVKMGKPVWGTCAGLIFLADRAVGQKEGGQELVGGLDCTVHRNFFGSQIQSFEADILVPQLTSQEGGPETYRGVFIRAPAVLDVGPDVEVLADYPVPSNKVLYSSSTVQIQEEDALPETKVIVAVKQGNLLATAFHPELTADTRWHSYFIKMTKEIEQGASSSSSKTIVSVGETSAGPEPAKPDLPIFQ
Protein: Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Metaphase-to-anaphase transition defect protein 3) (Q19294)
Organism: Caenorhabditis elegans
Function: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion. Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons.
Interaction partners:
- Abnormal embryogenesis protein 30
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 2
- Cell division cycle protein 16 homolog
- Cell division cycle protein 27 homolog
- WD repeat-containing protein fzy-1
- Anaphase-promoting complex subunit 1
- Protein gfi-3
- Suppressor of spindle checkpoint defect 1
Sequence:
MNVSFSTPVQNSTASRLALIQQAAARSGALPPAGQYRGSKLSPFDVSQMSGVSISMVERAKINGPEFVEELEWLRQQTTSRCFLDAEMWTNEILAHLPDKWCAPNTLNLYNQVSELVLDNTRSPMASPASNSLYAPGEDQMPTVKRNHTSRFAQSLIKNKEFRRAAFFLEKTMNGNKLDHFLHFRCLFLAYYQEHLENDAEGIERKTSFAEERSPFSLLYQRMEDKKLRENEDVWFEYLMGLLEVELGLKDLAEKSFRNVVIREPRIWPAWEALSRLIADIEDADKFVTSAEVKSLWMGDWFMTLVLQRFHQHSMAIQKAEQLVTRGMTGLPMIITKIAACSNARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYIRNDQKKLSTLAIEVYKVHKFRWETCCIVANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFEVFLVVYELVTSAEEKIIYAIAFLANHFFKIEDFDKASEYATKCLAFETLCQEGNRLFREIAKIQARESRLPVEEAPGPSNASAAGGQEAMDTEEAPQEGGEEEMSEGEDDFSF
Protein: Uncharacterized protein (Q385B5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQLRHELKFAGYGADKSTVLLGDNTSVTHCLQPIWKGEKVKICVDGVNGNDGSSAESDFVESECSESYVSSASSCSYRGGSPYESNFSGCTSSPRIGRSNLQGCREDDAVAGVGTHDGQDMTSVSFPVHGTLLSIRDPALTGGLLFQLHLADKEHTPYAEACRTAVVLGYSEQGEVFLLPVPSPCMTKKPSYYQSTPLLQLSLSELREYYSWGDNQLLEPTCDDVQSWELPHLGGFMVRPAFEHMWLATVFAVASDRLYYLSAWSAFVQFVGVAWGLPWVRKFPVNIPEGDPIVSFVAPLVGCNCGRSLREVYGLRELRRREQQGSTDVGTVPVPPGPVANADSSGWREFLRELQEVVGDAVADWSQLPAAAEHCDSKETTPPTSAAVTAAERLREDDGQLTSSYVVGKRSGDGGLLSEASVGVVPAVESMLRSFGTEVQQDIGRNISKDTGLPSPFLFTLFLKAVAYWKSNLLTEEQQSSQPLAFIDYYGTNPHERFVEAIDLLRVHQSKFLSETRPNARSSGNYCDQCVGPWTVQRIVRMLAEPAVTN
Protein: Adhesion G protein-coupled receptor L3 isoform X1 (Adhesion G protein-coupled receptor L3.1) (A0A2R8QM07)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Fibronectin leucine-rich transmembrane 3
- Teneurin-3
- Teneurin-4
- Teneurin transmembrane protein 1.
- Netrin receptor UNC5
- Netrin receptor UNC5
- Si:ch73-72b7.1.
- Unc-5 netrin receptor C.
- Netrin receptor UNC5
- Si:ch211-12m10.1.
Sequence:
MALTCPRRSFSESVQRSTGSSAVMWSTRLLFFFTLFTPVTLVLSRAPVPMAVVRRELSCEGYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENTRCYLPDAYKIMGFRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGVLRGVYQSEHLFESDHQAGSWCKDPLQSSNKIYYMPWTPYRTDTLTEYSSKEDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGRIVVSQLNPYTLRVEGSWDTSYDKRSASNAFMICGILYVVKSVYEDDDNEALGNKIDYMYNTEKSRETHLSIPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVIYSLDFGNNDNRLGFDPPSSVLLPDPLPPVRSSTTPPRPYTGTLRPSLTTTTTTTMVPPRRHNNVLPEALTRAPPSPQTPVTVDYCAPRLTAEISWPRTHQGQVAKQPCPPGTIGVATFNCLLGYWDPKGPDLSNCTSPWTNHITQRMRSGETAAIVARELAEQTKGELRPGDVPSTVKAMAQLVELLDVQLRNLTPGGKDTAARSLNKLQKRERSCRFFIQAMVETVNNLLQVRSQAAWRELSVAEQLRCATMLLDTVETGAFMLADNLLKTDTIQESTDNIQLEVARLSTDVNLADLSFPQSGLTGNSIHLSANTLKQQGRNGEIRMALVLYKNLGQYLSTENASVRLGSEAVYPNYSLIVNSPVITAAINKDSNKVYLSEPVVFTVKHIQQSEENFNPNCSFWSYSKRTMTGFWSTQDCRLLGTNRTHTSCSCTHLTNFAVLMAHVEVKKADQVHELLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFIAETLFLTGINRADQPIVCAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEYSRTKYFYLTGYGVPAVIVAVSAAVDYRSYGTERVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPDSGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCILQKKVRKEYGRCLRTHCCSGKSVESTISTSTKTSTARTPGRYSTNSQSRIRRMWNDTVRKQSESSFITADMNSSATLNRGTMANHLISNALLRPHGTNPYNTLLGESAVYNNPTANMFNTQASYRDSKGILNNARDSSVMDTLPLNGNHGNSYGVAAGDYLTYSSRGSEPPTTLEKKILKELTANYAPSYLNTQERQGKAHQGTLTNKLNNHLANGGVAGSSSIPKDDVMVLDNPGAFHRHDDGGGLSLELIREESQAPLLPPRPPPPENHAPLHTFTAHRRLPQENSESFFPLLPNDTHSSHTHTPRAHTHSPLRDSLYTSMPTLTDLPHGTDDLINGLHDDEDEEEEEDGEEEEGSELHLANGKGVIMESDDVYYKSMPNLGSRNHIQELESYYQMGRGGSDGFIAPPEKEDSSPEEQPPDPSQLVTSL
Protein: NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase) (Q61941)
Organism: Mus musculus (Mouse)
Function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Interaction partners:
- NAD kinase 2, mitochondrial
- NAD kinase
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- NAD-dependent protein deacetylase sirtuin-3
- NAD-dependent protein deacetylase sirtuin-1
- NAD-dependent protein deacylase sirtuin-5, mitochondrial
- NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Sequence:
MAHLLKTVVAGCSCPFLSNLGSSKVLPGKRDFVRTLRTHQALWCKSPVKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQALVKQGFNVVVESGAGEASKFPDDLYRAAGAQIQGMKEVLASDLVVKVRAPMVNPTLGAHEADFLKPSGTLISFIYPAQNPDLLNKLSERKTTVLAMDQVPRVTIAQGYDALSSMANISGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAVVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFSKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYVHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFHFEVKDDFDFGTMSHVIRGTVVMKDGKVIFPAPTPKNIPEEAPVKPKTVAELEAEKAGTVSMYTKTLTTASVYSAGLTGMLGLGIVAPNVAFSQMVTTFGLAGIIGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLALMGGHFYPSTTSQSLAALATFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLLPGGTFVGGYLAALYGGYNIEEIMYLGSGLCCVGALGGLSTQGTARLGNALGMIGVAGGLAATLGGLKPDPQLLAQMSGAMAMGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCMAEYIVEYPHFAMDATSNFTKIVAYLGTYIGGVTFSGSLVAYGKLQGILKSAPLLLPGRHALNAGLLAASVGGIIPFMADPSFTTGITCLGSVSGLSTLMGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAVEMIREANSIVITPGYGLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINSDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK
Protein: L-threonine dehydratase biosynthetic IlvA (EC 4.3.1.19) (Threonine deaminase) (P9WG95)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
Interaction partners:
- Putative acetolactate synthase small subunit
- 3-isopropylmalate dehydrogenase
- Branched-chain-amino-acid aminotransferase
- Acetolactate synthase large subunit IlvG
- Acetolactate synthase large subunit IlvB1
- Threonine synthase
- L-serine dehydratase
- Putative acetolactate synthase large subunit IlvX
- Putative acetolactate synthase large subunit IlvB2
- Tryptophan synthase beta chain
Sequence:
MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGATVYLKREDLQTVRSYKLRGAYNLLVQLSDEELAAGVVCSSAGNHAQGFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDEPDLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPVTLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAMLDLYQNEGIIAEPAGALSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPNDDITLFEYVKRNNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL
Protein: Two-component response regulator-like APRR5 (Pseudo-response regulator 5) (Q6LA42)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional repressor of CCA1 and LHY, thereby controlling photoperiodic flowering response. Involved in the positive and negative feedback loops of the circadian clock. With RVE8, forms a negative feedback loop of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. Proteolytic substrate of the E3 ubiquitin ligase SCF(ADO1) complex. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock. Negative regulator of shade avoidance response. Involved in the inhibition of leaf expansion in shade avoidance response.
Subcellular location: Nucleus {ECO:0000269|PubMed:31899321}.
Interaction partners:
- Adagio protein 1
- Protein LHY
- Protein CCA1
- Adagio protein 3
- Protein GIGANTEA
- Transcription factor LUX
- Adagio protein 2
- Protein EARLY FLOWERING 4
- Protein EARLY FLOWERING 3
- Protein REVEILLE 8
Sequence:
MTSSEEVVEVTVVKAPEAGGGKLSRRKIRKKDAGVDGLVKWERFLPKIALRVLLVEADDSTRQIIAALLRKCSYRVAAVPDGLKAWEMLKGKPESVDLILTEVDLPSISGYALLTLIMEHDICKNIPVIMMSTQDSVNTVYKCMLKGAADYLVKPLRRNELRNLWQHVWRRQTSLAPDSFPWNESVGQQKAEGASANNSNGKRDDHVVSGNGGDAQSSCTRPEMEGESADVEVSARDAVQMECAKSQFNETRLLANELQSKQAEAIDFMGASFRRTGRRNREESVAQYESRIELDLSLRRPNASENQSSGDRPSLHPSSASAFTRYVHRPLQTQCSASPVVTDQRKNVAASQDDNIVLMNQYNTSEPPPNAPRRNDTSFYTGADSPGPPFSNQLNSWPGQSSYPTPTPINNIQFRDPNTAYTSAMAPASLSPSPSSVSPHEYSSMFHPFNSKPEGLQDRDCSMDVDERRYVSSATEHSAIGNHIDQLIEKKNEDGYSLSVGKIQQSLQREAALTKFRMKRKDRCYEKKVRYESRKKLAEQRPRIKGQFVRQVQSTQAP
Protein: Dermorphin-2 [Cleaved into: Dermorphin] (P05421)
Organism: Phyllomedusa sauvagei (Sauvage's leaf frog)
Function: Dermorphin has a very potent opiate-like activity. It has high affinity and selectivity for mu-type opioid receptors.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MSFLKKSLLLILFLGLVSLSVCKEEKRVSEEENENEENHEEGSEMKRYAFGYPSGEAKKIKRESEEEKEIEENHEEGSEMKRYAFGYPSGEAKKIKRESEEENENEENHEEGSEMKRYAFGYPSGEAKKIKRESEEEKEIEENHEEGSEMKRYAFGYPSGEAKKIKRESEEENENEENHEEGSEMKRYAFGYPSGEAK
Protein: Formin homology 2 domain containing, isoform A (Q9VSQ1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MIVKMEPDELITFRVQYLVDSDPLSACTAFPIPVRAPTYAFATTMPLANQLGTILRLLNAPQSIDDAAIQVYKDGDYGAYLDLESSLAEQAEEIEGVNVSRKNSLVVRTQLNVRVQAIIEKLLSAQGSDLRRALFSLKQVFQEDKDLVHAFVALGGLNCLVRVGNCADQNYQNYILRALGQVMLYVDGMNGVMKHEPTMQWLYSLIASNYRSVVKTALKLLLVFVEYAESNCYVLVSAIHAVDASQGTLPWSNIMRLLKDYDNADAELVIYATSLINKTLAGLNDQDSFYDESDLLEQQGMETVIQRYMSKPGTDLDLLDQLQLYEAVLKFEDGESDGQRLPQNSMRKTQRYRPGANTTERRKSRRHSTDNSPASLTKVLPTTVLRMTPTQATVDEDSSGSTNSTEFSGGLFNEKKPRDGAGVTPGLRRRRERAERHKSFLKEQQEAAANGIFAALEQREGLGQIVTAIPATIQTGDSPPQSLQHEVPPCNNISGITNISNNNVSNLSCNDTPNNSLLVMSPSKQLLTGSHSISIINNSFDKASNNNQSEFLTKKNLFRERNSTVINGIMKNIQQTDSAYKKYENEANRLNNYYSQSPKHQIHQPIQPTPEVLLSPKKTLNASGFDFTPAPLSSTPVKCDVPPEPEPLSPVKKPAAAPPPPPPPPPPPPPPPGWWHAPIYNSPQARTLTSTNPELLPHPVDPSDMESEDQQLLLQLKRDHTVKDLTQKLSNLPMSPTQDSANRALVGDMSGLISKAKEGLAKSKSKGEISRSSSVDQDVKKSEPKKSENELHWEELVRNMTRPLNLCDLDFTDLRDDDEKDVLAPRSLGAGIPPPPPPLGGAIAPPPMMPPSLAPPPMYGYGGSLTNSVNSLNGSINGELVNGNNTIKKNKKTVKLFWKEVREDMIPQVVGKTIWDELPDANVDTQKLEHLFESRAKDLMTKKQQELNKSKEIIVLDHKRSNAINIAITKLPPPRAIKTAILKMDATVVTREGIDKLLNMLPTDEERGKIQEAQLSNPELPLGSAEQFLLTLASISELEARLKLWAFRLDFDNSEKEIAEPLMDLKQGIEILRQNRTFRSILSTLLSVGIFLNGAPVKGFQIEYLAKVPEVKDTVHKHSLLHHLCHMVMESSSDTSDLYSEIGPITRASKADFTDLAHNLNQLEAECKACWDRLKLIAKHDCPPPLKQKLVDFLADCAERIIILQIVHRRVMNRYRKFLLWLGMPQHSVAESRPNEFCRTLSEFALEYRTTRERVQQQLEKKANHRERNKTRGKLIIDMAKFKTKDDVADDELKKLLDTSSADQADGTLTWRRRRAEQLRSPITRQSEEQFTDGDDEILESLVKTATKAPGTRTTPRERKRTRHADRKSLRRTLKNGLTEEEKQHVAALIQTY
Protein: Uncharacterized protein (Q2YS16)
Organism: Brucella abortus (strain 2308)
Interaction partners:
Sequence:
MMPVIRLNDATFADLSVLKTWYGTKTPSETIDRIVREAMEQLDMERDDAAEEVTVTTSDGAMHFDAAPGLAFTKPLAASIDGKALHSPCWSALLLTMIAQVKTKGLSGDKLVRELAIPAKVERYDEEGFKFRPDLGISVQGQSASDCWKEVERLSKKWAIPVSVKFWWKQNPKAQYPGKTGILRSGPASA
Protein: THO complex subunit 2 (A0A0G2K8V3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- THO complex subunit 7
- THO complex subunit 1
- THO complex 3
- THO complex subunit 6 homolog
- Aly/REF export factor
- THO complex subunit 5 homolog
- THO complex subunit 1
- Spliceosome RNA helicase Ddx39b
- SAP domain-containing ribonucleoprotein
- ATP-dependent RNA helicase DDX39A
Sequence:
MAAATVVVPAEWIKNWEKSGRGDFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGNLKHEQASSVLNDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSDTVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELGQDLSGTITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPSGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEYKREIVEAKQIVRKLTMVVLSSEKLDERDKEKDKDDEKVEKPPDNQKLGLLEALLKIGDWQHAQNIMDQMPPYYAASHKLIALAICKLIHITVEPLYRRVGVPKGAKGSPVSALQNKRAPKQVESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNGHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPEKERMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGSKQQHKVHKYITSCEMVMAPVHEAVVSLHVAKVWDDISPQFYATFWSLTMYDLAVPHTSYEREVNKLKVQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEKDNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFDGGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVNKICQEEKEKRPDLYALAMGYSGQLKSRKSHMIPENEFHHKDPPPRNAVASVQNGPGGGTSSSSIGSASKSDESGAEETDKSRERSQCGTKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKVKEKEKEKKEKTPATTPEARVLGKESKEKPKEERPNKDDKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPSVESKSTQEREREKEPSRERDVAKEMKSKENVKGGEKPPVSGSLKSPVPRSDISEPDREQKRRKIDTHPSPSHSSTVKVTDILPKVPLGSENYASSPVISIHFLQDSLIDLKDSSAKLYINHNPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDITKRRKEENGTMGVSKHKSESPCESQYPNEKDKEKNKSKSSGKEKGSSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR
Protein: Ankyrin repeat protein, putative (Q382U5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPYPDVLQCRNSKVEAVVIKHDVAVAADGAVTSSYAVNAPCGTKDIYLAACDGDTVALDMFLRMGVDINSIGRPTQRYGTTFDRCSHFCATPLCFAAAYGREKAVAFLLEKGADAFRTSSTGIRPWEYARHRRYRIIMDMLQTAEEKQRANAKPTLPQG
Protein: Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) (P37879)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15046}. Cytoplasm {ECO:0000250|UniProtKB:Q15046}. Nucleus {ECO:0000250|UniProtKB:Q15046}. Cell membrane {ECO:0000250|UniProtKB:Q15046}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15046}. Secreted {ECO:0000250|UniProtKB:Q15046}. Note=Secretion is induced by TNF-alpha. Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E. {ECO:0000250|UniProtKB:Q15046}.
Interaction partners:
Sequence:
MATLQECKVKVDGEPKLSKNELKRRLKAEKKLAEKEAKQKELIEKQLSQAAAAAATNHTADNGVGVEEETLDPNQYYKIRSQAIHQLKVSGEDPYPHKFHVDISLTQFIQEYSQLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFVRINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIVRAKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMLSGMVKSITGSYKITYHPDGPEGEAYEIDFTPPFRRISMVEELEKALGVKLPETSLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVTMFLTDSNNIKEVLLFPAMKPEDKKETAAATETLESTTAGPSV
Protein: Pleckstrin homology domain containing A7 (A0A0G2K6Z8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Tetraspanin
- PDZ domain containing 11
- Afadin
- Disintegrin and metalloproteinase domain-containing protein 10
- ADP/ATP translocase 1
- Complement component C8 beta chain
- ADP/ATP translocase 2
- Apoptosis regulator Bcl-2
- Complement C8 alpha chain
- Complement C5
Sequence:
MSKQERNQRPSSMVSETSTAGTTSTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNLNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQAEHSGMRTYYFSADTLEDMNAWVRAMNQAAQVLSRSSLKRDKVERQAMPQANHTDACQECGHVGPGHSRDCPRRGYEDAIVFDRREQEEERFRSQRDTLEGRRDRSKARSPYLPAEEDALFVDLPGGPRGQQAQPQRAERNGLPPYGLGEQNGTSGYSRTAPPRANLEKHSQRKTNLAQTEHWAKAQKGDGRSLPLDQTLPRQGPSQPPSFLENYQTLPRNTRYPSGSSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPIGAGSPEFTEQGRSRSLLEVPRSISVPPSPSDIPPPGPPRPFPPRRPHTPAERVTVKPPDQRRSVDISLGGSPRKARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPMKIAESDTDVKLSIFCEQDRILQDLEDKIRALKENKDQLESVLEVLHRQTEQYRDQPQHLEKITCQQRLLQEDLVHIRAELCRESTEMENAWNEYLKLEKDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVMAGLSVNKENYRVLVGSVKNPERKTVPLFPHPSVPSLSPTESKPALQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVVSPLQSPTKATPQAEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDLKVELRSYVSEPELASFSGDVPRPSLGLVGSESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAENSSVTFSRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLLSARYLSQPLPGDLGSWKREQEFDLQLLERAAQGDRKDKEEGWLKVQATPVMELDLEPQDYDLDINRELSKPEKVSIPERYVEVDPEEPPSVEELQARYQKAEKIRNILARSSMCNLQPPGQDRNSLADLDTQMQEQERIINISYALASEASQRSKQVAAQAVTDP
Protein: DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3) (Q9P6L6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Nonessential DNA polymerase. Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Has a role in the bypass of abasic (AP) sites (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- DNA polymerase zeta processivity subunit
- DNA repair protein rev1
- DNA polymerase subunit delta-2
- Ubiquitin-conjugating enzyme spm2
- DNA polymerase kappa
- N-acetyltransferase eso1
- Ubiquitin-conjugating enzyme E2 13
- DNA polymerase delta catalytic subunit
- DNA polymerase alpha subunit B
- DNA polymerase epsilon subunit D
Sequence:
MRFSIEYIDWELSPCDPAYDFVGKDLPTANEELTTVPVIRVFGLNEEAETVCCFIHNVFPYIYVEYSSFAETLDLEVPDFLSQLQTSINYALALAARANPETYKPAVQSVQLVKGIPFYGYSFCFQKFLKICLFSPKNRDRLVDLFRQGAILNKVIQVYESHLPYLLQFMVDHNLYGCAPIDLDDSIIKRDDLLSFCNVEVHVSPNAILNACWLSERNIHTDLYETHASSPNSLLVTSLAEIWKSEASRRNLTSSDETNSFSKLHQSQFGLKEESSHEPRSSQHWKNEVAMKDLLKNLIKSKLESSSDVNTPLIFDPWPELPTIYSAIHTKDYVRPSQNDISVSQISVDEKICTSYESLPKIQLEQNTAPVIESSFEQLDSELERILGDTLFDSFPYVEPNVDRSKFPKSPLNSSQEVTIHSSQDRQSPPSSPLKDVPSQINPFSPSLRLKGGSPITKREIEFCRDLPNRPTSSEPNQGDTRKAGKRLKYSRNLDDYHICTQIPEDYSPKFLSQHESFVYKQQPPSTDDLYGTMKKLKIPFSIPTNVHYSSEKDIPSYSQEYLGKSHYPIGVSSRYLPEFQSDGSVSEKVRLNPLKLSNFHGERTWQYIKPAPLAVDLSNLESKEAVSEEIQSPQRLSRSKVFRKDPYSCVRILALELFCCSHGGLTPDPTKDSIECCFWAYQEDVNSSMIDRVGFIVVDKSASNSSFGRSFPSCTVLVVNSELELINEVIGLNRQLDPTIVCGYEVHNSSWGYLIERASYRFNYDLPEQLSRLKCTSKANFAKKENAWKYTTTSSINIVGRHVLNIWRILRGEVNLLNYSLENVVLNIFKKQTPYYNQADKVHLWQSSRFHEKQILLNYMLNRTRYCLEILSACAIVTKIREQARIIGIDFMSVISRGSQFKVESIMFRIAKPENYIFPSPSAKQVAEQNALEALPLVMEPKSDLYNNPVVVLDFQSLYPSIIIAYNLCYSTCLGPVKIVNGKVKLGFMFHSSNPNIVNLIKNDVYISPNGYAYVKENVRKSLLAKMLEELIETRNMVKRGMKDCDSDYVNKVLNSRQLALKLIANVTYGYTSASFSGRMPCSEIADTIVETGREILSYSLEYINTLDFCHAKVVYGDTDSLFVELPGATKEQAFDIGQQLANNITSRFPSPIRLKFEKIYFPCFLLAKKRYVGFKFESVSQKAPIFEAKGIETVRRDGTPVQQQLLRRCLEILFKTKDLSTVKKEFQNVCYQIMSGNVPVMDFCFSKEVRLEKYKELSTAPPGAVMARRLMTKDPRREPQYGERVPYLIIAAAPGTTLANRSVAPEEFLSSSFSQLDINYYINNSLIPPLDRFLNLLGASAQSWYHEMPKPRTSLKLTETVKGGIQKKTLDTFLMEKLCSSCLKNNIEIIPDKINSLCSDCLKNPCATISKAVTQHNAYNKKLSLLFDICRGCSKLSSSDPVLCKSNSCKVYYDRAKTENYAKVQAEMLTKTLGSLDW
Protein: Ethylene-responsive transcription factor ERF021 (Q9C9I2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- RING/FYVE/PHD zinc finger superfamily protein
- AT-hook motif nuclear-localized protein 11
- At3g10000
Sequence:
MAGLRNSGNSDKAQNDGKGVPSAYRGVRKRKWGKWVSEIREPGTKNRIWLGSFETPEMAATAYDVAAFHFRGREARLNFPELASSLPRPADSSSDSIRMAVHEATLCRTTEGTESAMQVDSSSSSNVAPTMVRLSPREIQAINESTLGSPTTMMHSTYDPMEFANDVEMNAWETYQSDFLWDP
Protein: Fibrinogen silencer binding protein (A0A8I5ZND1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRRSAAPSQVRGNSSKKARFVPPGRSTTGVSKEISMSPEAKLVQGAHQSQGDAGVCSSNPWLTEGSPVEMGDGARVDPLSPVLRCRSKLP
Protein: Chymotrypsin-like elastase family member 2B (EC 3.4.21.71) (Elastase-2B) (P08218)
Organism: Homo sapiens (Human)
Function: Acts upon elastin.
Subcellular location: Secreted.
Interaction partners:
- Carboxypeptidase A1
- Chymotrypsin-like elastase family member 3A
- Chymotrypsin-like elastase family member 3B
- Bile salt-activated lipase
- Colipase
Sequence:
MIRTLLLSTLVAGALSCGVSTYAPDMSRMLGGEEARPNSWPWQVSLQYSSNGQWYHTCGGSLIANSWVLTAAHCISSSGIYRVMLGQHNLYVAESGSLAVSVSKIVVHKDWNSDQVSKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGALPDDLKQGQLLVVDYATCSSSGWWGSTVKTNMICAGGDGVICTCNGDSGGPLNCQASDGRWEVHGIGSLTSVLGCNYYYKPSIFTRVSNYNDWINSVIANN