wanglab/gogpt-training-data huggingface dataset:
Protein: Heterogeneous nuclear ribonucleoprotein U (A0A1W2PQD4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRGGGGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRGNYNQQFWGQKPWSQHYHQGYY
Protein: Expressed protein (Os12g0111400 protein) (cDNA clone:001-109-C08, full insert sequence) (Q2QYP2)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MSGKDQKKAAALEEKLELLRSVTKSSAANETSILVDASKYIKELKDKVSQEPEQLGSTSSSMPMPRSEAAERSVDEQMVRHAVLQAIKKCMDGSSI
Protein: Protein orai (B6VQ32)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MDNYSLLSSEDHIEMRQFAAGIDPHAFGRSQNNRRDSLSSVNGEARVQFALSQTPPVENAPTGGSSSMGQSPPHHPANTSTNTATHHTLSPVIQCFQQDQHRGELDLSEKYNYDLSRAQLKASSRTSALLAGFAMVCLVELQYDQSTPKPLLIVLGVVTSLLVSVHLLALMMSTCILPYMEATGCTQDSPHIKLKFYIDLSWLFSTCIGLLLFLVEIGVIFYVKFTAVGYPTAGYITTAMLVPVGVVFVVFSYLIHKNRVSHSLGRFKHKVDTMKQFLDVEANLQKSTLAPSTIRDI
Protein: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) (Q9QYJ6)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10583409}.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Adenosine kinase
- Adenine phosphoribosyltransferase
- Hypoxanthine-guanine phosphoribosyltransferase
- GTP:AMP phosphotransferase AK3, mitochondrial
- Guanylate kinase
- Deoxycytidine kinase
Sequence:
MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKAEDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFLGECNNSLCVFTPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPATSKSTSEKPTRKVDD
Protein: Growth differentiation factor 5 (M0RAY4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Serine/threonine-protein kinase receptor
- Bone morphogenetic protein receptor type-1A
- Gremlin
- Bone morphogenetic protein receptor type-2
- Noggin
- Activin receptor type-2B
- Activin receptor type-2A
- Chordin
- Neuroblastoma suppressor of tumorigenicity 1
- C-X-C chemokine receptor type 4
Sequence:
MRLPKLLTLLLWHLAWLDLGLVCTVLGAPDLGQRPPGARPGLAKAEAKERPPLTRNIFRPGGHSYGVGATSARAKGSSGQTQAKKDEPRKVPPRASGSETKPGPSPQTRQAAARTVTPKGQLSGGKASAKAGSAPSSFLLKKTREPGTPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELRILRKKPLDVAKPAVPSSGRVAQLKLSSCPSGRQPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFERAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLANRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR
Protein: TBC domain-containing protein C23D3.03c (Q09844)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized membrane protein C30D10.09c
- Probable lipase C14C8.15
- Uncharacterized protein C594.02c
- Uncharacterized membrane protein C18H10.18c
- Putative mannan endo-1,6-alpha-mannosidase C1198.07c
- Putative mannan endo-1,6-alpha-mannosidase C970.02
- GTPase-activating protein gyp3
Sequence:
MESLESVDASSGSVGSYMSKSVRKHWWSRKGYHPTGSSKNGSRLKISSDENFQDELVVLDDAFLCNVPLELPSTSNAQKTAAESFSKLSPQDQLLSLQLNNVQESVFQQSTFNLPDALLDPGPASKEKQAVLSIGRPSWLPPKSKEEEKKHMREFEQIKKSAMRYDRQKQKEKIKMVEQKNKRNLYLVNVWEREILRNWPDALKSSRYAGIWRQGIPSRVRGRVWEKAIGNNLKLDYQSFFNARANAQKREAAEKAEQMNNANQFREDVCALELDLQSTMPHYSLFHTEGPLRRDLIGLLRAYSYYRFDTSYIPGTSFIGALLLLNMNLTSAFNCLANLLDKPFLQAVYTQDTSSLKSFYQTFLDTLKKNEPELATHLLIKLELVPDDFVYPLLRKLFIPMVSPEIASRILDCYVFEEDSFFIQLLMAVFKLLKPKLLVDDSRLVLSALLFENWDLGPEDEFMHFVYDISLS
Protein: C-C motif chemokine 7 (Intercrine/chemokine MARC) (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (Protein FIC) (Small-inducible cytokine A7) (Q03366)
Organism: Mus musculus (Mouse)
Function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity (By similarity).
Subcellular location: Secreted.
Interaction partners:
- C-C motif chemokine 2
- C-C chemokine receptor type 1
- Probable C-C chemokine receptor type 3
- C-C chemokine receptor type 2
- C-C chemokine receptor type 5
- C-C motif chemokine 6
- C-C motif chemokine 5
- C-C motif chemokine 12
- C-C motif chemokine 27
- C-C chemokine receptor 1-like protein 1
Sequence:
MRISATLLCLLLIAAAFSIQVWAQPDGPNASTCCYVKKQKIPKRNLKSYRRITSSRCPWEAVIFKTKKGMEVCAEAHQKWVEEAIAYLDMKTPTPKP
Protein: Lysophospholipase NTE1 (EC 3.1.1.5) (Intracellular phospholipase B) (Neuropathy target esterase homolog) (Q9USJ4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- Glycerophosphocholine phosphodiesterase gde1
- Lysophospholipid acyltransferase
- Triacylglycerol lipase ptl3
- Acyl-protein thioesterase 1
- cAMP-dependent protein kinase catalytic subunit
- AB hydrolase superfamily protein B1A11.02
- Malic acid transport protein
- Glutamine synthetase
- Glutamate synthase
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
Sequence:
MDITDRILQNRIVSKVIFFVLRSVTLSLVSVTRFSLFLLSFATITVPKWAYKIVTYSLTIQFNFKSLLFLFFVSICVVILVVRYRYLNKYARLPHEAPIKEAKLGPDTNIRPSEPRIGFQNYLDEFLSAISIFGYLEKPVFVELARHIRTQRVAEGNTIYLGEQSSFILVVDGCFQVFTAPEKDSAEVVEEAGQPEYRLLTEVSNGAPLSSFFTVLELFTELIPEATSKENPFKSTTSSLRPGSSTTTEAGANNASKPHMPQPKKARIIAKAKIDTTIAVIPANAFHHLVHKFPNSSAQIVQVILTRFQRVTFSTGYEYLGLSDAIFSIEKNFNSLTAYELPNYIRSDIIDDFKKEAMSEHLSQASNESFIVLRSKGAQSRLSNQYFSKAFDKEHGNFVSDIDRSTANAGDLLSSTNPHSTLLSTSVGPLRKFPLNRSYSREVGDYDISASFRDGLLQCIFKSLGVFNYELKEDNDDLCTENDSSEGDSDSLKKVDFLGQIAMMSATDREEVKSSIVVSTKKSTILEFAKEIEIIFYKKGTTIVRQGDHADGLYYIIDGFLDATCPSKLTFSTSYDTDLGMHSFMIKPGGIVNYQACVSNYRSFINVTARSDVLVGFLPRSCLERIIDQEPLISLTIAKRLISLVPSLLLKLDFAVGWIHLNPDQVVYEKNDPSDCVYVVLNGRLRSIEDERGSARTQVDYFNEYGKGDSVGELEMLLNNRRSSTLFAIRDSELAKIPETLFNALSLSHPAVGLQLSKIIANRMNLLLNNKSMDGMQHQPHEKHSIRTLAIVPSSSTGLLILFSQKLTSVLSVMGKSVKVLRQSSVLEHLGKHAFSRMGRFKLSSYLSDLEDKYDILIYVADSGVGSAWLQTCIRQADCIYILAEADQNPNIGEYEQHLIAMKSTARKELVLLHPERFCPSGLTRLWLKERPWVYAHHHVQLRIGLDNEISQNNEAKVFLNIIRAKVQNLHYGFRKYIDWKHLHPVYQANRAQDSDFARLARRICGKAIALVLGGGGARGISQIGILYALEEAGIPFDIIGGTSIGAFNGGLYAWEADLVPMFGRAKKFCGRMANLWRFVLDVTYPQAAYTTGHEFNRGIWKTFGEIHIEDFWLPFYANTTNITHSRMDIHSSGYAWRYIRASMSLAGLVPPMLSDSGDMLLDGGYMDNLTVSHMQSLGASSIFAIDVGSEDSREPMHYGDTVSGVWALISRWIPFIPKTSFPSLAEIQSRLTYVTSVATGEKVKSMPGCFYMRPPVKDFPTLEFGSFEKIYNVGYNYGKEYVEKLKTSHKLDDILSPRDTSKRHPKFLSSRRNSL
Protein: GTP-binding protein Rab-3D (EC 3.6.5.2) (Q63942)
Organism: Rattus norvegicus (Rat)
Function: Protein transport. Probably involved in regulated exocytosis (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit alpha
- Rab proteins geranylgeranyltransferase component A 1
- Regulating synaptic membrane exocytosis protein 2
Sequence:
MASASEPPASPRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWDTAGQERYRTITTAYYRGAMGFLLMYDIANQESFTAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVSAEDGQRLAGDLGFEFFEASAKENINVKQVFERLVDIICDKMNESLEPSSSPGSNGKGPALGDTPPPQPSSCGC
Protein: Carboxylic acid transporter protein homolog (P36035)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential to lactate transport.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Accumulation of dyads protein 2
- Protein ROD1
- Acetyl-coenzyme A synthetase 1
- Isocitrate lyase
- L-lactate dehydrogenase
- Succinate/fumarate mitochondrial transporter
- Malate synthase 1
- High-affinity hexose transporter HXT6
- Regulatory protein CAT8
- Transcription factor CSR2
Sequence:
MSSSITDEKISGEQQQPAGRKLYYNTSTFAEPPLVDGEGNPINYEPEVYNPDHEKLYHNPSLPAQSIQDTRDDELLERVYSQDQGVEYEEDEEDKPNLSAASIKSYALTRFTSLLHIHEFSWENVNPIPELRKMTWQNWNYFFMGYFAWLSAAWAFFCVSVSVAPLAELYDRPTKDITWGLGLVLFVRSAGAVIFGLWTDKSSRKWPYITCLFLFVIAQLCTPWCDTYEKFLGVRWITGIAMGGIYGCASATAIEDAPVKARSFLSGLFFSAYAMGFIFAIIFYRAFGYFRDDGWKILFWFSIFLPILLIFWRLLWPETKYFTKVLKARKLILSDAVKANGGEPLPKANFKQKMVSMKRTVQKYWLLFAYLVVLLVGPNYLTHASQDLLPTMLRAQLGLSKDAVTVIVVVTNIGAICGGMIFGQFMEVTGRRLGLLIACTMGGCFTYPAFMLRSEKAILGAGFMLYFCVFGVWGILPIHLAELAPADARALVAGLSYQLGNLASAAASTIETQLADRYPLERDASGAVIKEDYAKVMAILTGSVFIFTFACVFVGHEKFHRDLSSPVMKKYINQVEEYEADGLSISDIVEQKTECASVKMIDSNVSKTYEEHIETV
Protein: Pre-mRNA-splicing factor SNU114 (114 kDa U5 small nuclear ribonucleoprotein component) (Growth inhibitory protein 10) (P36048)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.
Subcellular location: Nucleus.
Interaction partners:
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- U2 small nuclear ribonucleoprotein A'
- Small nuclear ribonucleoprotein Sm D3
- Pre-mRNA-splicing factor CWC22
- Pre-mRNA-splicing factor SYF1
- Spliceosomal protein DIB1
- Pre-mRNA-splicing factor CWC15
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-splicing factor CLF1
- Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Sequence:
MEGDDLFDEFGNLIGVDPFDSDEEESVLDEQEQYQTNTFEGSGNNNEIESRQLTSLGSKKELGISLEHPYGKEVEVLMETKNTQSPQTPLVEPVTERTKLQEHTIFTQLKKNIPKTRYNRDYMLSMANIPERIINVGVIGPLHSGKTSLMDLLVIDSHKRIPDMSKNVELGWKPLRYLDNLKQEIDRGLSIKLNGSTLLCTDLESKSRMINFLDAPGHVNFMDETAVALAASDLVLIVIDVVEGVTFVVEQLIKQSIKNNVAMCFVINKLDRLILDLKLPPMDAYLKLNHIIANINSFTKGNVFSPIDNNIIFASTKLGFTFTIKEFVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFENVEKYPTFVEFILIPLYKIFSYALSMEKDKLKNLLRSNFRVNLSQEALQYDPQPFLKHVLQLIFRQQTGLVDAITRCYQPFELFDNKTAHLSIPGKSTPEGTLWAHVLKTVDYGGAEWSLVRIYSGLLKRGDTVRILDTSQSESRQKRQLHDISKTETSNEDEDEDDETPSCEVEEIGLLGGRYVYPVHEAHKGQIVLIKGISSAYIKSATLYSVKSKEDMKQLKFFKPLDYITEAVFKIVLQPLLPRELPKLLDALNKISKYYPGVIIKVEESGEHVILGNGELYMDCLLYDLRASYAKIEIKISDPLTVFSESCSNESFASIPVSNSISRLGEENLPGLSISVAAEPMDSKMIQDLSRNTLGKGQNCLDIDGIMDNPRKLSKILRTEYGWDSLASRNVWSFYNGNVLINDTLPDEISPELLSKYKEQIIQGFYWAVKEGPLAEEPIYGVQYKLLSISVPSDVNIDVMKSQIIPLMKKACYVGLLTAIPILLEPIYEVDITVHAPLLPIVEELMKKRRGSRIYKTIKVAGTPLLEVRGQVPVIESAGFETDLRLSTNGLGMCQLYFWHKIWRKVPGDVLDKDAFIPKLKPAPINSLSRDFVMKTRRRKGISTGGFMSNDGPTLEKYISAELYAQLRENGLVP
Protein: Regulatory protein NPR4 (BTB/POZ domain-containing protein NPR4) (Q5ICL9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways.
Subcellular location: Nucleus {ECO:0000269|PubMed:15634206}.
Interaction partners:
- Cullin-3A
- Transcription factor TGA2
- Transcription factor TGA6
- Transcription factor TGA5
- Cullin-3B
- Transcription factor TGA3
- Transcription factor TGA1
- Transcription factor TGA7
- Isochorismate synthase 1, chloroplastic
- Ankyrin repeat-containing protein BDA1
Sequence:
MAATAIEPSSSISFTSSHLSNPSPVVTTYHSAANLEELSSNLEQLLTNPDCDYTDAEIIIEEEANPVSVHRCVLAARSKFFLDLFKKDKDSSEKKPKYQMKDLLPYGNVGREAFLHFLSYIYTGRLKPFPIEVSTCVDSVCAHDSCKPAIDFAVELMYASFVFQIPDLVSSFQRKLRNYVEKSLVENVLPILLVAFHCDLTQLLDQCIERVARSDLDRFCIEKELPLEVLEKIKQLRVKSVNIPEVEDKSIERTGKVLKALDSDDVELVKLLLTESDITLDQANGLHYAVAYSDPKVVTQVLDLDMADVNFRNSRGYTVLHIAAMRREPTIIIPLIQKGANASDFTFDGRSAVNICRRLTRPKDYHTKTSRKEPSKYRLCIDILEREIRRNPLVSGDTPTCSHSMPEDLQMRLLYLEKRVGLAQLFFPAEANVAMDVANVEGTSECTGLLTPPPSNDTTENLGKVDLNETPYVQTKRMLTRMKALMKTVETGRRYFPSCYEVLDKYMDQYMDEEIPDMSYPEKGTVKERRQKRMRYNELKNDVKKAYSKDKVARSCLSSSSPASSLREALENPT
Protein: Mediator of RNA polymerase II transcription subunit 23 (F4I4P3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 22b
- Mediator of RNA polymerase II transcription subunit 14
- Cyclin-dependent kinase E-1
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 22a
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 10b
- Mediator of RNA polymerase II transcription subunit 10a
Sequence:
MDQSQRTVAATPSSSRSYQFHPARAAIIDLFNLYLGRGSRQKPDESLRDPPNKSQKRVHAPNRDLPPRNEQFLLDFELLQSQFNDPEQLRTITESVLISLVVQCSNHAPRAEFLLFALRTLCRISYINWDTFLPSLLSSVSAAEASLSQGVQAAAATAGSSATSSQSVVPVSVNPTSLLPSAHGIGSPSASEVKSVENGQQIARAGQIVRENAMRNSQRIRAAAVNSLRQLSCKIILIGVESSLKPVTHAEIFQYMMNWLVNWDRRDLGTEDSVGKSWRSEKTLAEWLRSCLDVIWLLVEEGESRIPFYELLRSGLQFIENIPDDEALFTLIMEIHRRRDAMAMHMLMLDQHLHCPSFGTHRIVSQITANVPPEAVPHLRHSPITYPSVLGEPLYGEDLAMSIPKGSLDWERAVRCIRHAIRTTPSPDWWKRVLVVAPCYRPSTQAGPIPGAVFTSDMICEAIIDRIVELLKLTNSGNDCFGIDLVSVTFPPLYADANCWQEWLVFSDIFFFLIKSGCTDFVDFIDKLVLRLNGVDNHILRTNHVTWLLAQIIRVELVMTALNSDAKKVETTRKILSFHREDRNSDPNNPQSVLLDFVSSCQNLRIWSLSTTTRAYLNNEQLLKGKQIDEWWRSKGERMMDYMNMDDRSIGMFWVVSYTMAQPACETVINWLSSAGMAELPGLQPNDRVMMTQEVTPLPMSLLSGFSMNLCLKLALQMEEALFVSQVVPSIAMVETYTRLLLISPHSMFRSHFSQLAQRNASLLSKPGVTLLVLEILNYRLLPLYRYQGKSKTLMYDVTKIISALKGKRGDHRIFRLAENLCMNLILSLRDFFSVKREGKGPTEFTETLNRITIMTLAITIKTRGIADPDHMVYLQTMLEQILATSQHTWSEKTMRHFPSLLRETLKGRVDKRGLSIQAWQQAETTVINQCTQLLSPSAEPAYVSTYLSHSFPQHRQYLCAGACLLMQGHAENINSTNLARVLREVSPEEVTANIYTLVDVLLHHVHVDLQQGQSLEAVLDKAGANLAFFFWTHEMLPLDIFLLALIDRDDDPHALIIAMSLLKTPDLLLRIKNYCQNRGSPEHWLVTQVFKRNELQKALGNHLSWKDRYPTFFDDIAARLLPVIPLVLYRLIENNAMEQADNLLLAHSHFLAYHPLRFTFVRDILAYFYGHLPGKLVLRMLKVLDLSKIPFSESFPQYISPTGAPVCPPLDYFASLLLNLVNNVIPPLSSSSNCSSRSGSMADILNSSARPPHGKTPGTSQPGPANASEGQKAFYQIQDPGTYTQLVLETAVIEILSLPVSAAQIVSSLVQIIVNIQSTLIQSGNGFHGAANGVGQGSVLPTSPSGGSTDSMSASRSTCLIPGINTASFVSRSGYTCQQLSCLLIQACGLLLAQLPPDFHVQLYLEAARVTRETWWLKDGKRSQGELDSAVGYALMDPTWAAQDNTSTAIGNIVALLHAFFSNLPQEWLDGTNAIITNLRPVTSVAMLRVVFRIMGPLLPRLASTHTLFNKTLMLLLSALVDVFGKTAQTTAPVEASQIADLIDFLHHIIHYEGQGGAVQTSSKPRPDILALIGRAAETLRPDVQHLLAHLKTNPNSSIYAAAHQQNTAKTNTS
Protein: 14-3-3 protein epsilon (14-3-3E) (P62259)
Organism: Mus musculus (Mouse)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P62258}. Cytoplasm {ECO:0000250|UniProtKB:P62258}. Melanosome {ECO:0000250|UniProtKB:P62258}.
Interaction partners:
- M-phase inducer phosphatase 3
- 14-3-3 protein zeta/delta
- Nuclear distribution protein nudE-like 1
- M-phase inducer phosphatase 2
- Serine/threonine-protein kinase B-raf
- 14-3-3 protein gamma
- Forkhead box protein O3
- 14-3-3 protein beta/alpha
- 14-3-3 protein theta
- Platelet-activating factor acetylhydrolase IB subunit beta
Sequence:
MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ
Protein: Gamma-secretase subunit pen-2 (Presenilin enhancer protein 2) (Q9U357)
Organism: Caenorhabditis elegans
Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12110170}; Multi-pass membrane protein {ECO:0000269|PubMed:12110170}. Golgi apparatus membrane {ECO:0000269|PubMed:12110170}; Multi-pass membrane protein {ECO:0000269|PubMed:12110170}. Note=Predominantly located in the endoplasmic reticulum and Golgi region.
Interaction partners:
- Presenilin sel-12
- Presenilin spe-4
- Presenilin hop-1
- Nicastrin
- Gamma-secretase subunit aph-1
- Protein lin-12
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
- Peptidase A1 domain-containing protein
Sequence:
MDISKLTDVKKVDLCKKYFLIGACFLPLVWIVNTFWFFSDAFCKPINAHRRQIRKYVIASIVGSIFWIIVLSAWEIFFQHYRAQGLVWTDFLTFVFPTGRV
Protein: Ferritin, mitochondrial (EC 1.16.3.1) (Q9D5H4)
Organism: Mus musculus (Mouse)
Function: Catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q8N4E7}.
Interaction partners:
- Frataxin, mitochondrial
- Transferrin receptor protein 1
- Mitoferrin-2
- Natural resistance-associated macrophage protein 2
- Mitoferrin-1
Sequence:
MLSCFWFFSKHISSALMSLPRVLHRFTAPQCLASRYPLGPLLASPRRLLASVASSQDSTRPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALYNFSKYFLRQSLEEREHAEKLMKLQNQRGGRICLQDIKKPDKDDWECGLRAMECALLLEKNVNQSLLDLHTLASEKGDPHLCDFLETHYLHEQVKSIKELGDHVHNLVTMGAPAAGLAEYLFDKHTLGSESKH
Protein: L(+)-tartrate dehydratase subunit beta (L-TTD beta) (EC 4.2.1.32) (P0AC35)
Organism: Escherichia coli (strain K12)
Interaction partners:
- L
- D-malate dehydrogenase [decarboxylating]
- L-tartrate/succinate antiporter
- Malate dehydrogenase
- NADP-dependent malic enzyme
- Citrate synthase
- Fumarate hydratase class I, anaerobic
- Fumarate hydratase class I, aerobic
- Probable dehydratase YbiW
- Probable dehydratase PflD
Sequence:
MKKILTTPIKAEDLQDIRVGDVIYLTGTLVTCRDVCHRRLIELKRPIPYDLNGKAIFHAGPIVRKNGDKWEMVSVGPTTSMRMESFEREFIEQTGVKLVVGKGGMGPLTEEGCQKFKALHVIFPAGCAVLAATQVEEIEEVHWTELGMPESLWVCRVKEFGPLIVSIDTHGNNLIAENKKLFAERRDPIVEEICEHVHYIK
Protein: PAN2-PAN3 deadenylation complex subunit pan3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) (Q7SDP4)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pabp-1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by rgb-30/xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. par-2/pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit par-1/pan2 to mRNA via its interaction with RNA and with pabp-1.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03181}.
Interaction partners:
- PAN2-PAN3 deadenylation complex catalytic subunit pan2
- Polyadenylate-binding protein, cytoplasmic and nuclear
- Exonuclease
- Tethering factor for nuclear proteasome sts1
- RNA exonuclease 3
- NACHT domain-containing protein
- Exonuclease domain-containing protein
- RNA exonuclease 4
Sequence:
MAATRYNSGDLRRQVGSPRAKNRDTKETLCRNVVIYGHCRWEDSGCTFNHDQNKASVSQTDLNSNRRVFNVESPSFTPANQQQSAGKKSTFSSQAASAAPFTPRGVGTSTPTLQQANDSTIFNPAAIREFTPQNYDVGNTISQNGAQHVTQDGGLYSDPFSISSLGQTMPPQGQYNPYANDPNNLAGAGAGLYQPAGFGNGLVHPPNYHLYQPPSELYRPSLQPYQRTTYDFFIPKDRRENLQKKLFHMQQLLPNSGLPNLDRWHSLFPLDTKATRNSTCFGYPSWMYKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLAARCLELSKIIWENNRIRLAACSILDVLHHDSPNRKTIEELQQEDFVKFGRIILALATNTPTLNFNNIDAALATIVPRYSTQLRGVLEWLIKPSAPGETKTVETLLGGITTHLANFANFVMQESDEKEFHLMRELENGRIARLMFKLSVVNERGDSCGVHNWSETGERLLLKLFRDYVFHQVDADGKARLDTNHYLNCLSKLDASSEEQILLTSRDNATVFVVSYRSIRQMLDRAYGELGKESKPSATGATI
Protein: BAP29/BAP31 transmembrane domain-containing protein (Q584J8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVSLLALEVNALIVPAFIVFVLFIIPIPLLSRAMSRAMGYAERVNFYGVSVLTIVTVTTFIGFVLQVIDWRRKYSGGKPSFAEMTMEIDWEGRKWRLERNMYIHALATVLSAAVMKFARLHNALEKKER
Protein: Proline-rich family protein (A0A178VY90)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSTPDPNPNPNPNPSVSVAVSTPIVTASESPVTQPNTVITPSSQPQPQTPASSYRAIAPLHRHHPHQNIYTNPLPIRRSNSVTNSPHQPPHPDPSSLIYPFGSSGRGFPTRPVRQNSNSVADPVGSPSPGGYTPRGPVYGYHHGQFVSNLDPMNQFMRAAHPQNQQSPQLGSGHMKGVPHFLQPRATPSPTSILDNSGHKKARSRDDALVLVRKRKVRITEGASLYSLCRSWLRNGAHEGIKPQRIDMMTCLPKPLPVDKTETSLPKDLVEEAICEEDKEDEESVKHLSESDLLKRHIDRAKKVRARLREERLKRIARYKARLALLLPPFGEQCRNE