wanglab/gogpt-training-data huggingface dataset:
Protein: 2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase) (O59736)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Interaction partners:
- 3-isopropylmalate dehydratase
- Dihydroxy-acid dehydratase, mitochondrial
- Branched-chain-amino-acid aminotransferase, mitochondrial
- Probable acetyl-coenzyme A synthetase
- Acetyl-CoA acetyltransferase
- Probable acetolactate synthase small subunit
- Acetolactate synthase, mitochondrial
- Acetyl-CoA hydrolase
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- Acetyl-CoA carboxylase
Sequence:
MKSTFEAAGRVAKGMLKDPSKKYKPFKGIQLPNRQWPNKVLTKAPRWLSTDLRDGNQALPDPMNGQEKLRYFKLLCSIGFKEIEVGFPSASQTDFAFVRHLIETPGLIPDDVTISALTPSREPLILRTIEALRGAKNATVHLYNACSPLFREVVFRNSKQETLDLAIKGSKIVTAATKNALESKETNWGFEYSPETFSDTEPDFALEVCEAVKGMWKPSAAQPIIFNLPATVEMSTPNTYADLIEYFSTNISEREKVCVSLHPHNDRGTAVAAAELGQLAGGDRIEGCLFGNGERTGNVDLVTLAFNLYTQGVSPNLDFSKLDEIIRITEDCNKINVHPRHPYAGNLVFTAFSGSHQDAISKGLKAYDERKAVDPVWKVPYLPLDPHDVNSEYAAIIRVNSQSGKGGVAYLLKTNCGLDLPRALQVEFGSIVKDYSDTKGKELSIGEISDLFYTTYYLEFPGRFSVNDYTLSSNGPQSKCIKCVVDIKGEKKDTPSRVVIEGVGNGPLSALVDALRRQFNISFDIGQYSEHAIGSGNGVKAASYVEIIFNNTSFWGVGIDADVTSAGLKAVMSGVSRASRAFAK
Protein: Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A) (Q8R4K8)
Organism: Mus musculus (Mouse)
Function: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.
Subcellular location: Secreted.
Interaction partners:
- Bone marrow proteoglycan
- Insulin-like growth factor-binding protein 5
- Stanniocalcin-2
- Insulin-like growth factor-binding protein 4
- Insulin-like growth factor 1
- Insulin-like growth factor 2
- Insulin-like growth factor-binding protein 1
Sequence:
MRLWSWVLRLGLLSAALGCGLAERPRRVRRDPRAVRPPRPAAGPATCATRAARGRRASPPPPPGGAWEAVRVPRRRQQRAARGAEEPSPPSRALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQKSPAVITGLYDKCSYTSRDRGWVMGIHTTSDQGNRDPRYFFSLKTDRARKVTTIDAHRSYLPGQWVHLAATYDGRLMKLYMNGAQVATSAEQVGGIFSPLTQKCKVLMLGGSALNHNFRGHIEHFSLWKVARTQREIVSDMETRGLHTPLPQLLLQENWDNVKRTWSPMKDGNSPQVEFSNAHGFLLDTNLEPPLCGQTLCDNTEVISSYNQLPSFRQPKVVRYRVVNIYDDHHENPTVSWQQIDFQHQQLAEAFQHYNISWELEVLNINSSSLRHRLILANCDISKIGDEKCDPECNHTLTGHDGGDCRQLRYPAFMKKQQNGVCDMDCNYERFNFDGGECCDPDITDVTKTCFDPDSPHRAYLDVNELKNILRLDGSTHLNIFFANSSEEELAGVATWPWDKEALMHLGGIVLNPSFYGIPGHTHTMIHEIGHSLGLYHIFRGISEIQSCSDPCMETEPSFETGDLCNDTNPAPKHKFCGDPGPGNDTCGFHGFFNTPYNNFMSYADDDCTDSFTPNQVSRMHCYLDLVYQSWQPSRKPAPVALAPQVVGHTMDSVMLEWFPPIDGHFFERELGSACDLCLEGRILVQYAFNASSPMPCGPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQGCYLELEFRYPLVPESLTIWVTFVSSDWDSSGAVNDIKLLTISGKNISLGPQNVFCDIPLTIRLRDVGEEVYGIQIYTLDEHLEIDAAMLTSTVDSPLCLQCKPLQYKVLRDPPLLEDVASLLHLNRRFMDTDLKLGSVYQYRIITISGNEESEPSPAAIYTHGSGYCGDGVIQKDQGEECDDMNKVNGDGCSLFCKQEVSFNCIDEPSRCYFHDGDGMCEEFEQKTSIKDCGVYTPQGFLDQWASNASVSHQDQQCPGWVVIGQPAASQVCRTKVIDLSEGISQHAWYPCTITYPYYHLPQTTFWLQTYFSQPMVAAAVIIHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCRNNPLIIPVVHDLSQPFYHSQAVHVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYSPAEQSCVHFACQAADCPELAVGNASLNCSSNHHYHGAQCTVSCQTGYVLQIQRDDELIKSQVGPSITVTCTEGKWNKQVACEPVDCGIPDHHHVYAASFSCPEGTTFGRRCSFQCRHPAQLKGNNSFLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKPGYHVPGSSRKSKKRAFKTQCTQDGSWQEGTCVPVTCDPPPPKFHGLYQCTNGFQFNSECRIKCEDSDASQGRGSNIIHCRKDGTWSGSFHVCREMQGQCSAPNQLNSNLKLQCPDGYAIGSECAISCLDHNSESIILPVNLTVRDIPHWMNPTRVQRIVCTAGLQWYPHPALIHCVKGCEPFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQNDCACRDPEAQEHNRKDLRGYSHG
Protein: Leukocyte immunoglobulin-like receptor subfamily A member 5 (CD85 antigen-like family member F) (Immunoglobulin-like transcript 11) (ILT-11) (Leukocyte immunoglobulin-like receptor 9) (LIR-9) (CD antigen CD85f) (A6NI73)
Organism: Homo sapiens (Human)
Function: May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12393390}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:12393390}.
Interaction partners:
- Tyrosine-protein kinase SYK
- Tyrosine-protein phosphatase non-receptor type 6
Sequence:
MAPWSHPSAQLQPVGGDAVSPALMVLLCLGLSLGPRTHVQAGNLSKATLWAEPGSVISRGNSVTIRCQGTLEAQEYRLVKEGSPEPWDTQNPLEPKNKARFSIPSMTEHHAGRYRCYYYSPAGWSEPSDPLELVVTGFYNKPTLSALPSPVVTSGENVTLQCGSRLRFDRFILTEEGDHKLSWTLDSQLTPSGQFQALFPVGPVTPSHRWMLRCYGSRRHILQVWSEPSDLLEIPVSGAADNLSPSQNKSDSGTASHLQDYAVENLIRMGMAGLILVVLGILIFQDWHSQRSPQAAAGR
Protein: Virulence factor-related M protein (P16946)
Organism: Streptococcus pyogenes serotype M49
Subcellular location: Secreted, cell wall {ECO:0000255|PROSITE-ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-ProRule:PRU00477}.
Interaction partners:
Sequence:
MARQQTKKNYSLRKLKTGTASVAVALTVLGAGFANQTEVRAEGVNATTSLTEKAKYDALKDENTGLRGDQTKLVKKLEEEQEKSKNLEKEKQKLENQALNFQDVIETQEKEKEDLKTTLAKATKENEISEASRKGLSRDLEASRAAKKELEAKHQKLEAENKKLTEANQVSEASRKGLSNDLEASRAAKKELEAKYQKLETDHQALEAKHQKLEADLPKFQRPSRKGLSRDLEASREANKKVTSELTQAKAQLSALEESKKLSEKEKAELQAKLDAQGKALKEQLAKQTEELAKLRAEKAAGSKTPATKPANKERSGRAAQTATRPSQNKGMRSQLPSTGEAANPFFTAAAATVMVSAGMLALKRKEEN
Protein: Small ribosomal subunit protein uS15m (28S ribosomal protein S15, mitochondrial) (MRP-S15) (S15mt) (Q9DC71)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P82914}.
Interaction partners:
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein mS29
- Small ribosomal subunit protein mS35
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS11m
Sequence:
MLRAAWRALSSVRAQAVTRAPVPALRGGSSASLLSARCGLQPPSLLRAARAYAAVQKPVQPKQDDEPPSSAFIKEYKDIIPNIEKVDDVVKRILSLEMASRKEKLKIKQEQLMNKIVENPEDSRTLEAQIIALTVRIRNYEEHMQKHRKDKAHKRHLLMSIDRRKKLLKILRQTNYDVFEKTCKELGVEYTLPPLHFQKVHRRFLAKKALCIRVYQEVQKLKKQKRALKAAAAAAKKEKNEGVPENPSNAVPEKTQVN
Protein: Myosin 2 (Q5AKW2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Rab family GTPase
- Ras-related protein SEC4
- Actin
- Mlc1p
- SWI5-dependent HO expression protein 3
- Kip4p
- Calmodulin
- Exocyst complex component SEC15
- Myosin-binding domain-containing protein
- Myosin 1
Sequence:
MVSLYDVGTRCWYPDEKLGWISATVKSNKKNGNKHIIEFVPENDDSQVFTIETDNLSEENDKLPPLRNPPILEAAEDLTSLSYLNEPAVLQAIKLRYSQLNIYTYSGIVLIATNPFQRVEQLYSQDIIQAYAGKRRGELDPHLFAIAEDAYRCMKEDGENQTIVVSGESGAGKTVSAKYIMRYFATVEEDSELQSNIGTEHKSDMSDVEKQILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDKETSIIGARIRTYLLERSRLVFQPSTERNYHIFYQMLAGMSSSEKEALGLQTADDYKYTNQGGMPQIEGIDDAEEFRITNEALSLIGIDKSKQSEIYKILAALLHIGNIDIAATKNDAHLSSDEPNLTKACELLGIDAVSFAKWCVKKQITTRNEKITSNLNHKQALVARDSFAKYIYSALFDWLVDYVNSDLCPDEVAARVKSFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYIKEQIEWSFIDFADNQPCIDVIENRLGILSLLDEESRLPAGNDESWIEKMFQNLDKEPTNKVFKKPRFGQTKFIVSHYALDVTYDIEGFIEKNRDTVGEGHLEVMKNTTNPLLQSILEIIDKNAAALEASKPETKAPRAKIANKKPTLGSMFKNSLIELMKTINSTNVHYIRCIKPNEQKKAWEFDTLMVLSQLRACGVLETIRISCAGFPSRWTYVEFADRYHILVPSQDWIRVMSGDTTQESVSGLCNQILTTNIENKEKYQLGNTKIFFKAGMLAHFEKLRSDKLFKSAVMIQKNMRKRFYRKRYLETRASHIQLQGLIRGYMSRKRVREEQERVAATLIQTSIRGYLARKQFAQTVLSVVTIQKSVRGLQARRNYLKLRELSSAVVIQKSWKAYQARSSYQTQRKSAVIIQSAFRRQYAIRELQQLKVEAKSLNKLKEVSYQLENKVIDLTQSLTAKIQDNKKLMEEIANLKALLEQQGQAHETLKTRELEFNEKFDSQNAEHQQEVENLNRELETIKNEYASAGAKIEQLYKEQAELKQEVQRNIEELNKAKDDLVKRDTIEVDLKSHIEQLKTELAKLQQQQSEARNGSAVLVNSKARNVNKRHSSAVAWNSPNSLDNSNRPVSVIAVSNDEDANIDDINDELFKLLRDSRQLHREIVDGLLKGLKIPPSGIAADLTRKEVLFPSRIIIIILSDMWRLGLTKESEDFLGEVLSSIQLIVSALKDDDVIPHGAFWLSNTHELYSFVSYAQHTIIANDNLAHEMSEEEFDEYLKLVAVVKEDFESLSYNIYNMWMKKMEKDLEKKAVSAVVLSQALPGFMAPESSPFLAKVFSGGVQYKMDDILSFFNTVYWAMKSYFIEMEVINEVIIELLRFVDALCFNDLIMRRNFLSWKRGLQLNYNVTRLEEWCKSHDIEEGSNYLSHLLQAAKLLQLRKNTPDDISIIYEICFALKPIQIQKLISQYYVADYETPIAPNVLQAVADKVKESDSSNSDDLFELVSTDGHFNDPFRNIALRPFSRVEAYVPAWLNLPVIRRIVELVAKNASVQESQSTIGVEEEANGL
Protein: At1g32920/F9L11_25 (Q93WI1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- Serine/threonine-protein kinase PCRK1
- Mediator of RNA polymerase II transcription subunit 9
- RING-H2 finger protein ATL2
- F-box protein PP2-A13
- Mediator of RNA polymerase II transcription subunit
- BON1-associated protein 1
Sequence:
MNSMFSAFDALFAEVMGKNLMASSFTATTATTKPAAAPQTQTQEKANASSKKIGLVQKIPRFALELDGLHCFETIVRS
Protein: Adenylate kinase 7 (AK 7) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 7) (Q96M32)
Organism: Homo sapiens (Human)
Function: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:21080915}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:29365104}. Note=Detected along the full length of sperm flagellum, where it colocalizes with alpha-tubulin. {ECO:0000269|PubMed:29365104}.
Interaction partners:
- Adenylosuccinate lyase
- Adenine phosphoribosyltransferase
- Adenosine kinase
- Deoxycytidine kinase
- Pyruvate kinase PKM
- Pyruvate kinase PKLR
- Thiamine pyrophosphokinase 1
- Cancer-related nucleoside-triphosphatase
- Ectonucleoside triphosphate diphosphohydrolase 2
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Sequence:
MAEEEETAALTEKVIRTQRVFINLLDSYSSGNIGKFLSNCVVGASLEEITEEEEEEDENKSAMLEASSTKVKEGTFQIVGTLSKPDSPRPDFAVETYSAISREDLLMRLLECDVIIYNITESSQQMEEAIWAVSALSEEVSHFEKRKLFILLSTVMTWARSKALDPEDSEVPFTEEDYRRRKSHPNFLDHINAEKMVLKFGKKARKFAAYVVAAGLQYGAEGGMLHTFFKMAWLGEIPALPVFGDGTNVIPTIHVLDLAGVIQNVIDHVPKPHYLVAVDESVHTLEDIVKCISKNTGPGKIQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQTGFVENINTILKEYKQSRGLMPIKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECCNVRPEDPVDFLAEYLFKNNPEAQ
Protein: Kunitz-type trypsin inhibitor IVTI (C0HKQ3)
Organism: Inga vera (River koko)
Function: Inhibits bovine trypsin but not chymotrypsin. Also inhibits trypsin-like enzymes from midgut of several lepidopteran species and inhibits larval development in those species. Has fungicidal activity against yeast C.buinensis. Has a bacteriostatic effect against E.coli. Is not cytotoxic.
Interaction partners:
Sequence:
EVVLDSDGEMLRNGGKYYLSPASPIGGGA
Protein: Mitogen-activated protein kinase hog1 (MAP kinase hog1) (EC 2.7.11.24) (BcSAK1) (Stress-activated mitogen-activated protein kinase) (A1IVT7)
Organism: Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Function: Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity). Involved in vegetative and pathogenic development like conidia formation, sclerotial development, and in penetration into unwounded plant tissue.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Interaction partners:
Sequence:
MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSAKDNLTGSNVAVKKIMKPFSTPVLSKRTYRELKLLKHLKHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDVWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIHTIASENTLRFVQSLPKRERQPLASKFTQADPLAIDLLEKMLVFDPRARIKAAEGLAHEYLSPYHDPTDEPAAEERFDWSFNDADLPVDTWKIMMYSEILDYHNVINDAQNLTESQ
Protein: Retinoblastoma-binding protein 5 (RBBP-5) (Q8BX09)
Organism: Mus musculus (Mouse)
Function: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (By similarity). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Histone-lysine N-methyltransferase 2A
- WD repeat-containing protein 5
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- CXXC-type zinc finger protein 1
- Protein dpy-30 homolog
- Histone-lysine N-methyltransferase 2C
- Histone-lysine N-methyltransferase 2D
- Histone-lysine N-methyltransferase SETD1B
- Host cell factor 1
- Lysine-specific demethylase 6A
Sequence:
MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVPSSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSTKGKVQAELSQSLAAGGAISELL
Protein: Mediator of RNA polymerase II transcription subunit 17 (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Q8VCD5)
Organism: Mus musculus (Mouse)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 26
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 19
Sequence:
MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGPDGDAPDWGGAGADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQSPQTLQLISKKKSLAGAAQILLKGAERLTKSVAENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSDDKKSQKCAAEKPGQEDHLYVLEHNLHLLIREFHKQTLSSIVMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGRVIMLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL
Protein: Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (TRF-proximal protein homolog) (Q9R0X0)
Organism: Mus musculus (Mouse)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 7
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 11
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 30
- Mediator of RNA polymerase II transcription subunit 27
Sequence:
MGVTCVSQMPVAEGKSLQQTVELLTKKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQAGKLMYVMHNSEYPLSCFALFENGPCLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYCDFLVKVGTVTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHAPGAPTVFGNRHDAVYGPADTMIQYMELFNKIRKQQQVPVAGIR
Protein: Matrix metalloproteinase-A (MMP-A) (MMP-Y19) (EC 3.4.24.-) (Zinc metalloprotease 1) (G5EGM1)
Organism: Caenorhabditis elegans
Function: Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15960981}; Single-pass type I membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:15960981}. Note=Localizes to puncta on the cell surface that are often concentrated at the invasive basolateral membrane of the anchor cell. {ECO:0000269|PubMed:15960981}.
Interaction partners:
- Ig-like domain-containing protein
- Transcription factor fos-1
- Cadherin-3
- Zinc finger protein egl-43
- Nuclear hormone receptor family member nhr-67
- Integrin alpha ina-1
- EGL-17
- Integrin beta pat-3
- Netrin receptor unc-40
- C-factor
Sequence:
MFTGLHDILIILFLLVTLKIAQNVDHTKFLQKYGYLTSGDNQLSSESLSDALKNMQRMAGLEETGELDERTIQMMERPRCGHPDVEDHQKSRGKRYAPPQFKWKEKIITYGCKAVGTSTRISLDDLRRTMHQAASQWSELADVEIVESSVKNPMMVISAGRENHYPCTVRFDTKTLAHAFFPTNGQIHINDRVQFAMTNYTERMGANSLYSVVAHEMGHALGFSHSPDIDSVMFAYDTPRKWKFTSMDKYNMRSYYGAKASKKENEEEERKTENEDKRRKTEKDRGRTREHESDDIRPNECRVENPIVVQYRGEYLIFKSQWVWRVSSDWKRLIIKAVPINQLFPGLPNPIDAAVTVGHNLWVFVGEMIYVIYGNHMVHAPLRLSDIGINEKYVDLAYEWHYFNPPAVYIWKGSRYWKLDEKMYHRRVDERYPKDTDLNWARVPKGVHSAFTYEKEIHLLRGNQVFRMNSSRSVFDIADGYPQPLQSFFGFCPRNEKLVLNSSSSHFSLIYATITILILIF
Protein: Gb|AAF01528.1 (Q9FLC4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MARIGALILVLFISISQLASFSTARKFPVGIPSVIDGVIFSGEISAVSKKVTVVGCEGEDDHLTAGYSSYITGKFGSLVLNALPKGSVPASGPSKRINDVKT
Protein: DNA double-strand break repair protein Mre11 (EC 3.1.-.-) (Q58719)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.
Interaction partners:
- DNA double-strand break repair Rad50 ATPase
- Uncharacterized protein MJ0585
- Flap endonuclease 1
- Replication factor A
- Probable ATP-dependent helicase MJ0942
- DNA repair and recombination protein RadB
- DNA repair and recombination protein RadA
- Ribonuclease VapC4
- DNA ligase
- Type 2 DNA topoisomerase 6 subunit A
Sequence:
MMFVHIADNHLGYRQYNLDDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKALRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLALLKDYVKILDGKDVINVNGEEIFICGTYYHKKSKREEMLDKLKNFESEAKNYKKKILMLHQGINPYIPLDYELEHFDLPKFSYYALGHIHKRILERFNDGILAYSGSTEIIYRNEYEDYKKEGKGFYLVDFSGNDLDISDIEKIDIECREFVEVNIKDKKSFNEAVNKIERCKNKPVVFGKIKREFKPWFDTLKDKILINKAIIVDDEFIDMPDNVDIESLNIKELLVDYANRQGIDGDLVLSLYKALLNNENWKELLDEYYNTKFRG
Protein: C-type lectin domain family 3 member B (Tetranectin) (F1SRC8)
Organism: Sus scrofa (Pig)
Interaction partners:
- Plasminogen
- Secreted phosphoprotein 24
Sequence:
MELWGPYLLLCLFSLLTQVTAETPTPKVKKPANAKKDAASPKILEELKTQLDTLAQEVALLKEQQALQTVCLKGTKVHMKCFLAFVQAKTFHEASEDCISRGGTLGTPKTGSENDALYEYLRQSVGAEAEVWLGFNDMADEGAWVDMTGGHIAYKNWETEITAQPDGGKVENCAALAGAANGKWFDKRCRDKLPYVCQFAIV
Protein: cDNA, FLJ96578, highly similar to Homo sapiens fatty acid hydroxylase (FAAH), mRNA (B2RDE6)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Interaction partners:
Sequence:
MENEPVALEETQKTDPAMEPRFKVVDWDKDLVDWRKPLLWQVGHLGEKYDEWVHQPVTRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVLYLSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHVQHHKAPFDGSRLVFPPVPASLVIGVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHTLTPEKPHLKTQ
Protein: PWWP domain-containing protein 2B (E9Q9M8)
Organism: Mus musculus (Mouse)
Function: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes. Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (By similarity). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation. Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:34180153}.
Interaction partners:
- Lysosomal enzyme trafficking factor
Sequence:
MEPRAGCRLPVRVEQVVNGALVVTVSCGERSFAGILLDCTKKSGLFGLSPSTLLPLADNSSAVSCHGQAPEEGTGEVMQLETGPLHPHHKDPEKDQPPKTAVSEPPPPLIPPVPAGNLPPFPPYFEGAPFPHPLWLRNTYQQWVPQPPPRTIKRTRRRLSRNRDPGRLILSTIRLRPRQVLCEKCKSTVSPQEASPSPLNTPKPRRRLGSGPDSEHRKPEEPEDSAVIATAAPRRSKREKREEDRVAGERVPRSPVIKISYSTPQGKGEVVKIPSRVHGSVEPFCPQQSLQNGSQDSEVSRDVEPRGGGDRPPSGSSASIPKLKLTRPVPPISDLPPPKIRLKPHRLGDGEHEPLYRAELVEELNGCPRGPLVSSPALFADGSSHGLEDLSSGSSGEDDDLKRFPQGKHGRDGLAFLVDCPGRRTDCTSESVCSTDSLDELKSSGSEVTSPDTGDLSSGDSASVPSSSADTRQTVPPLTVRLHTQSVSRCVTEDGRTVAVGDIVWGKIHGFPWWPARVLDISLGQKEDGEPSWQEAKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRKKKGMYRKAITEAANATQHVAPEIRELLTQFEM