wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) (Q80XP9)
Organism: Mus musculus (Mouse)
Function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A1, SLC12A2, SLC12A3, SCNN1A, SCNN1B, SCNN1D and SGK1. Inhibits SLC12A4, SLC12A5, SLC12A6 and SLC12A7. Phosphorylates WNK4. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9BYP7}. Note=Mediates formation and localizes to cytoplasmic membraneless compartment in response to hyperosmotic stress. {ECO:0000250|UniProtKB:Q9H4A3}.
Interaction partners:
- Kelch-like protein 3
- Solute carrier family 12 member 2
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Solute carrier family 12 member 5
- Kelch-like protein 2
Sequence:
MATDSGEPASTEDSEKPDGVSFENRAARAVAPLTVEARIKEKYSTFSASGENIERKRFFRKSVEMTEDDKVAESSRRDERKAATNISRVDKVPTNVLRGGQEVKYEQCSKATSESSKDCFKEKTEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTLKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIREKKPAGCLEERRDSQCKYVRNVLPQQQTATLQPTPGPHTAAEYEETEVDQHVRQQFLQGKPQQQSSSVRGDTSSEPTAGPVLHSDTSSHPTVAYSSNQTTSSQEQPKLTQSPVLPVVQGQSSVMPIYAAGVGVVSQSQISPLTIQKVSQIKPVSQPIGAEQQATLQNPDFVRSLNQDVTSVKENTNNPDTPSGNGKQDRNKQRRASCPRPEKGTKFQLTVLQVSVSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLENEKEKFVEELRAIVGQAQEILHVHSAVEKSIGVDSVALESNSNQTGSSEQVLINSASTQTSNESAPQSSPVGRWRFCINQTIKNREAQSPPSLQPSMAMVPGLHPFPSSRNTSNQAISQNTVFTIENNPGHRELFTSKLDHKDVVDGKIGEHASIETEQSSISYQVEDDRQIMTPATDNSNYSAALVCPVPGECEALTSQAGMFMPTYPNQQAAVLADVHIAYPGESVPIGGNAALTSVLVSSDQKPQSLSVQQPTIDAEFISKEGETTVNTETSSPKAVIATQTPGFEPAVILPATILESDGERPPKMEFADNRIKTLDEKLRNLLYQEHSISSICPESQKDTQSIDSPFSSSAEDILSYSMPEVIAISHCGIQDSPAQSPNFQQTGSKILSNVAASQPAHISVFKKDLNVITSVPSELCLHEMSPDASLPGDPEAYPAAVSSDGTIHLQTGGGYFGLSFTCPSLKNPISRKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEDKRSAIASDPIPLTREFSSDTRALSRCKAMSGSFQRGRFQVITVPQQQPVKMMSFGKDHRPPFNKTTVQSSEQALTFAEAAVSQLIEVEPAMPTHKASVSSRKLRTLYETFKEDKGDPEQGDIVSYSTACETSVSSVATEKNVTSTTEVSVQSGSEPLDKEKNESTPGKQTCTNEFSATLAGNRKSVTKTRPEGDQYLPLREEQAYAQTQNSLFYSPSSPMSSDNESEIEDEDLKVELQRLREKHIQEVVSLQTQQNKELQELYERLRATKDNKAQSSEVPLSPASPRRPRSFKSKLRSRPQSMTHSDNLVVKDALGVESNTVSCQQSPASKKGMFTDDLHKLVDDWTRETVGHFPSKPSLNQLKQSQQKSEAENWNKSCESTPSTMGYTSNWISSLSQIRGAAPTSLPQGLPLPSFHGPLASYGMPHVCQYNAVGAAGYPVQWVGISGPAQQSVVLPTQSGGLFQPGMNLQSFPAPPVQNPASIPPGPK
Protein: Myomesin-3 (Myomesin family member 3) (Q5VTT5)
Organism: Homo sapiens (Human)
Function: May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.
Subcellular location: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.
Interaction partners:
Sequence:
MTLPHSLGGAGDPRPPQAMEVHRLEHRQEEEQKEERQHSLRMGSSVRRRTFRSSEEEHEFSAADYALAAALALTASSELSWEAQLRRQTSAVELEERGQKRVGFGNDWERTEIAFLQTHRLLRQRRDWKTLRRRTEEKVQEAKELRELCYGRGPWFWIPLRSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIRRCAIEDSATYTVRVKNAHGQASSFAKVLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLSCLFSEDVLDAESIQWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGLYMVRVPSPFGPREQSTYVLVRDAEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWIACHEAPGGTCRCPIQGLVEGQSYRFRVRAISRVGSSVPSKASELVVMGDHDAARRKTEIPFDLGNKITISTDAFEDTVTIPSPPTNVHASEIREAYVVLAWEEPSPRDRAPLTYSLEKSVIGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAFRDTQTSVSLTWDPVKDPELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSEAGVGESSAATEPIRVKQALATPSAPYGFALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFECKEWTMPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQWKPVTPGPISGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPSMPTDPVLLEDKPGAHEIEVGVDEEGFIYLAFEAPEAPDSSEFQWSKDYKGPLDPQRVKIEDKVNKSKVILKEPGLEDLGTYSVIVTDADEDISASHTLTEEELEKLKKLSHEIRNPVIKLISGWNIDILERGEVRLWLEVEKLSPAAELHLIFNNKEIFSSPNRKINFDREKGLVEVIIQNLSEEDKGSYTAQLQDGKAKNQITLTLVDDDFDKLLRKADAKRRDWKRKQGPYFERPLQWKVTEDCQVQLTCKVTNTKKETRFQWFFQRAEMPDGQYDPETGTGLLCIEELSKKDKGIYRAMVSDDRGEDDTILDLTGDALDAIFTELGRIGALSATPLKIQGTEEGIRIFSKVKYYNVEYMKTTWFHKDKRLESGDRIRTGTTLDEIWLHILDPKDSDKGKYTLEIAAGKEVRQLSTDLSGQAFEDAMAEHQRLKTLAIIEKNRAKVVRGLPDVATIMEDKTLCLTCIVSGDPTPEISWLKNDQPVTFLDRYRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKYGSETGQVTISVFKHGDEPKELKSM
Protein: Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) (Q15599)
Organism: Homo sapiens (Human)
Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.
Subcellular location: Endomembrane system {ECO:0000269|PubMed:9054412}; Peripheral membrane protein {ECO:0000269|PubMed:9054412}. Nucleus {ECO:0000269|PubMed:9054412}. Apical cell membrane {ECO:0000250}. Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern. {ECO:0000250}.
Interaction partners:
- Ezrin
- Sodium/hydrogen exchanger 3
- Podocalyxin
- Radixin
- Lysophosphatidic acid receptor 2
- Cystic fibrosis transmembrane conductance regulator
- Moesin
- Na
- Chloride anion exchanger
- Beta-2 adrenergic receptor
Sequence:
MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF
Protein: Phospholipid/glycerol acyltransferase domain-containing protein (A0A060X5E8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- Cardiolipin synthase
- Lysophospholipid acyltransferase 5
- Lysophospholipid acyltransferase 5
- Phospholipid/glycerol acyltransferase domain-containing protein
- Phospholipid/glycerol acyltransferase domain-containing protein
- Cholinephosphotransferase 1
- Cholinephosphotransferase 1
- AB hydrolase-1 domain-containing protein
- Phosphatidylethanolamine N-methyltransferase
- Phospholipid/glycerol acyltransferase domain-containing protein
Sequence:
MKLPNKQHHSSENEDGSDLPPPFRNPFVHELRFTPLEKIRIGVMTVTVFPVRLFFAVLLMLLAWPFAFAASLGRSELAVETETWWRRICDIALRGIMRAMWFCGGFHWVTVKGEPAPPSQAPILTLAPHSSYFDAIPVTMTMASIVMKTESKNIPVWGTLIKFIRPVFVSRSDQDSRKKTVEEIKRRAHAGGEWPQIMIFPEGTCTNRSCLITFKPGAFIPAVPVQPVVLRYPNRMDTITWTWQGPGAFEILWLTLCQFHNPIEIEYLPLYTPSEEEKNNPALFANNVRSIMAKALELPITDLSFDDCQLSLAKGPMRVPSNSSLLQFNRLARRLGLRAGTTDTVLEQQASKARKLWGYTLGLGDFAHYLDLPVTDMLTELHSLFNQWELWKHTYSVY
Protein: Copine 1 (Q5JX44)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGDGKWHLVYRSEVIKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDPSSPDS
Protein: Protein turtle homolog B (Immunoglobulin superfamily member 9B) (D3ZB51)
Organism: Rattus norvegicus (Rat)
Function: Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion (By similarity).
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:23751499}; Single-pass membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000269|PubMed:23751499}.
Interaction partners:
- Neuroligin-2
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Sequence:
MIWYVATLIASVISTRGLVAQVAHGLREEPEFVTARAGEGVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLSASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHNALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVHVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLSVPLGPSWLLVDSLEPETAYQFSVLAQNRLGTSAFSEVVTVNTLAFPVTTPEPLVLVTPPRCLTANRTQQGVLLSWLPPANHSFPIDRYIMEFRVGERWEMLDDAIPGTDGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTDDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSRKYSVAKAEAEAEATTPIELISRGPDGRFVMGPSEMEPSVKGRRIEGFPFAEETDMYPEFRQSDEENEDPLVPTSVAALKPQLTPMSSSQDSYLPPPAYSPRFQPRGLEGPSGLGGRLQATGQARPPAPRPFQHGQYYGYLSSSSPGEVEPPPFYMPEVGSPLSSVMSSPPLHTEGPFGHPTIPEENGENASNSTLPLTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLHPCDVAESLQPKPCLPRGLPPAPLQVPAAYPGMLSLEAPKGWVGKSPGRGPIPAPPATKWQERPMQPLVSQGQLRHTSQGMGIPVLPYPEPAEPGGHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSSTGSPSQSSRSGSPSYRPTMGFTTLATGYPSPPPGPAPPAPGDNLDVFGQTPSPRRMGEEPLRPEPPTTLPTSG
Protein: 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase) (Q76NV5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Key enzyme in the degradation of tyrosine.
Interaction partners:
- Homogentisate 1,2-dioxygenase
- Tyrosine aminotransferase
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Short-chain dehydrogenase/reductase family protein
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
- Propionyl-CoA carboxylase beta chain, mitochondrial
- Cyclin-C
- Putative RNaseIII
Sequence:
MEGFDHVTFWVGNALQAATYYIARFGFQNLAYSGLETGNRQFATHVIHQNNIIMAFTSPLTGDNKDYADHMMRHGDGVKDIAFNVKDVQHIYDEAVKAGAQSVKEPHQIKDEHGIVTLATIMSPYGETTHTFVDRSQYKGAFLPGFTYKVASDPLSNITEPVGLNLIDHVVSNHADKMMEPVVQWYEKVLQFHRFWSVDDKTIHTEYSSLRSVVVADKSEKVKLPINEPANGIRKSQIQEYVDFYNGAGVQHIALKTDNIIDAISKLRSRGVSFLTVPKTYYTSLREKLQHSSLEIKEDLDTLEKLHILIDYDDKGYLLQIFTNNVEDKPTVFFEIIQRNNHDGFGAGNFKSLFEAIERQQETRGNL
Protein: Eukaryotic translation initiation factor 5A (eIF-5A) (G1K0V8)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSEDHHDEEQFDSAESGAAATFPKQCSALRKNEHVMIRGRPCKIVEMSTSKTGKHGHAKVHMVAIDIFTTKKLEDICPSTHNMDVPVVKRREYILMSIEDGFCSLMDPESCELKDDLKMPEGDLGNTIREALEKDEGSVLVQVVAACGEEAILGYKISTKE
Protein: Protein trichome birefringence-like 16 (F4K5L5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- At5g20670)
- Probable pectinesterase 8
- Microtubule-associated protein 70-4
- Polygalacturonase QRT2
- Xyloglucan endotransglucosylase/hydrolase protein 15
Sequence:
MNETFSATPRSMTIHRYRMKRGALRRRARDISVMLVVLVCATVVIWTWDRTPTSAFLPPESHYLKLQSEEKVEKLPTALNTETKDSYSSAIPFVNKEESKEDSSDNKDTEEEEEKQVEEVTVSNTNRGKIPTIEEKKGEHEVIASEPKYRKTPTREDFKLEKVKHEVAVGEGEATETTHIKETNSDPKSNILATDEERTDGTSTARITNQACNYAKGKWVVDNHRPLYSGSQCKQWLASMWACRLMQRTDFAFESLRWQPKDCSMEEFEGSKFLRRMKNKTLAFVGDSLGRQQFQSMMCMISGGKERLDVLDVGPEFGFITPEGGARPGGWAYRFPETNTTVLYHWSSTLCDIEPLNITDPATEHAMHLDRPPAFLRQYLQKIDVLVMNTGHHWNRGKLNGNKWVMHVNGVPNTNRKLAALGNAKNFTIHSTVSWVNSQLPLHPGLKAFYRSLSPRHFVGGEWNTGGSCNNTTPMSIGKEVLQEESSDYSAGRAVKGTGVKLLDITALSHIRDEGHISRFSISASRGVQDCLHWCLPGVPDTWNEILFAMI
Protein: Nutritionally-regulated adipose and cardiac-enriched protein (Q8BNX7)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000269|PubMed:23029450}; Single-pass membrane protein {ECO:0000269|PubMed:23029450}.
Interaction partners:
Sequence:
MRSAARVSRSNSHPRTRHPTRENEGTTWGSQPSRTERDGDRKCPPSILRPRRQECGCHGGEPQKTSRHVRFREPLEVAVHYIARKDTTAAIKVPSRPASHGGSPLQPASCSGSLFLWLTLCALLGVVLVLYCGQAKRVTAALEDLLAQLLALILRLWRVVLACWH
Protein: Oxygen-evolving enhancer protein 1-2, chloroplastic (OEE1) (33 kDa subunit of oxygen evolving system of photosystem II) (33 kDa thylakoid membrane protein) (Manganese-stabilizing protein 2) (MSP-2) (OEC 33 kDa subunit) (Q9S841)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stabilizes the manganese cluster which is the primary site of water splitting. Regulates dephosphorylation and turnover of the PSII reaction center D1 protein.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:11719511, ECO:0000269|PubMed:18431481}; Peripheral membrane protein {ECO:0000269|PubMed:11719511}; Lumenal side {ECO:0000269|PubMed:11719511}. Note=Associated with the photosystem II complex.
Interaction partners:
- Oxygen-evolving enhancer protein 3-2, chloroplastic
- Oxygen-evolving enhancer protein 3-1, chloroplastic
- Oxygen-evolving enhancer protein 2-1, chloroplastic
- Putative oxygen-evolving enhancer protein 2-2
- Cytochrome b559 subunit beta
- Expressed protein
- Chlorophyll a-b binding protein CP26, chloroplastic
- Photosystem II protein D1
- Cytochrome b559 subunit alpha
- Photosystem II D2 protein
Sequence:
MATSLQAAATFLQPAKIAASPSRNVHLRSNQTVGKSFGLDSSQARLTCSLHSDLKDFAGKCSDAAKIAGFALATSALVVSGAGAEGAPKRLTYDEIQSKTYMEVKGTGTANQCPTIDGGSETFSFKAGKYTGKKFCFEPTSFTVKADSVSKNAPPDFQNTKLMTRLTYTLDEIEGPFEVGSDGSVKFKEEDGIDYAAVTVQLPGGERVPFLFTVKQLEASGKPESFSGKFLVPSYRGSSFLDPKGRGGSTGYDNAVALPAGGRGDEEELSKENVKNTAASVGEITLKITKSKPETGEVIGVFESLQPSDTDLGAKVPKDVKIQGVWYGQIE
Protein: Minor capsid protein P30 (Protein P) (GpP) (P27391)
Organism: Enterobacteria phage PRD1 (Bacteriophage PRD1)
Function: Minor capsid protein essential for stable capsid assembly of complete particles.
Subcellular location: Virion. Note=The capsid contains 60 copies of P30.
Interaction partners:
Sequence:
MALINPQFPYAGPVPIPGPAPTETMPLLNYRVEGRIAGIQQARQFMPFLQGPHRAVAEQTYHAIGTGIQMGQTFNQPLINTQEG
Protein: Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Lysophospholipid receptor B4) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8) (Q91X56)
Organism: Mus musculus (Mouse)
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-13
- Sphingosine kinase 1
- Sphingosine kinase 2
- Sphingosine-1-phosphate transporter SPNS2
Sequence:
MEPGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAAVCLAVCAFIVLENLAVLLVLVRHPRFHAPMFLLLGSLTLSDLLAGAAYATNILLSGPLTLRLSPALWFAREGGVFVALAASVLSLLAIALERHLTMARRGPAPAASRARTLAMAVAAWGASLLLGLLPALGWNCLGRLETCSTVLPLYAKAYVLFCVLAFLGILAAICALYARIYCQVRANARRLRAGPGSRRATSSSRSRHTPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARACPVLLQADPFLGLAMANSLLNPIIYTFTNRDLRHALLRLLCCGRGPCNQDSSNSLQRSPSAAGPSGGGLRRCLPPTLDRSSSPSEHLSPQQDGVDTSCSTGSPGVATANRSLVPTATD
Protein: Bifunctional enzyme CysN/CysC [Includes: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) (ATP-sulfurylase large subunit) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (APS kinase) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase)] (P9WNM5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
Interaction partners:
- Probable sulfate-binding lipoprotein SubI
- Sulfate adenylyltransferase subunit 2
- Sulfate/thiosulfate import ATP-binding protein CysA
- Sulfate transport system permease protein CysT
- Adenosine 5'-phosphosulfate reductase
- Probable sulfate-transport integral membrane protein ABC transporter CysW
- Sulfite reductase [ferredoxin]
- Precorrin-3B synthase CobG
- Molybdenum import ATP-binding protein ModC
- uroporphyrinogen-III C-methyltransferase
Sequence:
MTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWASVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIRHLVLAVNKMDLLGWDQEKFDAIRDEFHAFAARLDVQDVTSIPISALHGDNVVTKSDQTPWYEGPSLLSHLEDVYIAGDRNMVDVRFPVQYVIRPHTLEHQDHRSYAGTVASGVMRSGDEVVVLPIGKTTRITAIDGPNGPVAEAFPPMAVSVRLADDIDISRGDMIARTHNQPRITQEFDATVCWMADNAVLEPGRDYVVKHTTRTVRARIAGLDYRLDVNTLHRDKTATALKLNELGRVSLRTQVPLLLDEYTRNASTGSFILIDPDTNGTVAAGMVLRDVSARTPSPNTVRHRSLVTAQDRPPRGKTVWFTGLSGSGKSSVAMLVERKLLEKGISAYVLDGDNLRHGLNADLGFSMADRAENLRRLSHVATLLADCGHLVLVPAISPLAEHRALARKVHADAGIDFFEVFCDTPLQDCERRDPKGLYAKARAGEITHFTGIDSPYQRPKNPDLRLTPDRSIDEQAQEVIDLLESSS
Protein: Cell division cycle 14A (A0A2R8YDJ8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGNFLSRENKVQVISESDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPVSAQTPPPGPQNPECNFCALPSQPRLPPKKFNSAKEAF
Protein: Phosphoheptose isomerase (EC 5.3.1.28) (Sedoheptulose 7-phosphate isomerase) (P63224)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Subcellular location: Cytoplasm.
Interaction partners:
- D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase
- Bifunctional protein HldE
- Lipopolysaccharide heptosyltransferase 2
- ADP-L-glycero-D-manno-heptose-6-epimerase
- Lipopolysaccharide heptosyltransferase 1
- Lipopolysaccharide heptosyltransferase 3
- Lipopolysaccharide core heptose
- Lipopolysaccharide glucosyltransferase WaaG
- Histidine biosynthesis bifunctional protein HisB
Sequence:
MYQDLIRNELNEAAETLANFLKDDANIHAIQRAAVLLADSFKAGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHISCVGNDFGFNDIFSRYVEAVGREGDVLLGISTSGNSANVIKAIAAAREKGMKVITLTGKDGGKMAGTADIEIRVPHFGYADRIQEIHIKVIHILIQLIEKEMVK
Protein: Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5) (Q14940)
Organism: Homo sapiens (Human)
Function: Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues. Acts as a negative regulator of dendritic spine growth. Plays a role in postsynaptic remodeling and signaling. Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12205089, ECO:0000269|PubMed:15699339, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21296876, ECO:0000269|PubMed:21551074, ECO:0000269|PubMed:24936055}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:12205089, ECO:0000269|PubMed:21296876}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendritic spine membrane {ECO:0000269|PubMed:21551074}; Multi-pass membrane protein {ECO:0000255}. Synaptic cell membrane {ECO:0000269|PubMed:21551074}; Multi-pass membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:24006492}. Note=Cycles between recycling endosome and plasma membrane in response to diverse stimuli. Its internalization is clathrin- and beta-arrestin dependent and its plasma membrane insertion from the recycling endosomes requires phosphoinositide 3-kinase (PIK3CA) and SCAMP2. {ECO:0000269|PubMed:12205089, ECO:0000269|PubMed:15699339, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21296876}.
Interaction partners:
- Sodium/hydrogen exchanger 9B2
Sequence:
MLRAALSLLALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKHRGLGFQDTAAVILTVESEEEEEESDSSETEKEDDEGIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQAPILTCLPPHPRGTEEPQVPLHLPSDPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGSRL
Protein: General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) (P13984)
Organism: Homo sapiens (Human)
Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.
Subcellular location: Nucleus {ECO:0000269|PubMed:10454543}.
Interaction partners:
- General transcription factor IIE subunit 1
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB2
- Transcription initiation factor IIE subunit beta
- TATA-box-binding protein
- Transcription initiation factor IIB
- General transcription factor IIF subunit 1
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerase II subunit RPB7
Sequence:
MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELKPEYRHYQGEEKSD