wanglab/gogpt-training-data huggingface dataset:
Protein: RING finger protein unkempt (Q86B79)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for late larval/early pupal development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1339381}.
Interaction partners:
- Raptor, isoform B
- Headcase protein
- LD23868p
Sequence:
MLANETNKLLLSSQQEKPNHYTYLKEFRVEQCQSFLQHKCNQHRPFVCFNWHFQNQRRRRPVRKRDGTFNYSADNYCTKYDETTGICPEGDECPYLHRTAGDTERRYHLRYYKTCMCVHDTDSRGYCVKNGLHCAFAHGMQDQRPPVYDIKELETLQNAESTLDSTNALNALDKERNLMNEDPKWQDTNYVLANYKTEPCKRPPRLCRQGYACPQYHNSKDKRRSPRKYKYRSTPCPNVKHGEEWGEPGNCEAGDNCQYCHTRTEQQFHPEIYKSTKCNDVQQAGYCPRSVFCAFAHVEPCSMDDPRENSLSASLANTSLLTRSSAPINIPNTTLSNSINDFNSGSFAVNIPSSSLTYSPTNHANLFNVDAFNYGGSNKLSNSLSATQNDSSLFFPSRIISPGFGDGLSISPSVRISELNTIRDDINSSSVGNSLFENTLNTAKNAFSLQSLQSQNNSDLGRITNELLTKNAQIHKLNGRFEDMACKLKIAELHRDKAKQEAQEWKERYDLAQIQLNLPAELRDLSIQKLKQLQSKLRTDLEEVDKVLYLENAKKCMKCEENNRTVTLEPCNHLSICNTCAESVTECPYCQVPVITTHT
Protein: AAA+ ATPase domain-containing protein (Q382P2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Heat shock protein 20, putative
- GrpE protein homolog
- Uncharacterized protein
Sequence:
MPHSGYPFGSSSVVGVEGDDRHSSVSLFVILFLCVLLTAVEPSVAGADVRSTVDEVVADTSEPTCPPAPVCSRYKWLSSSQLYCWMSKLPSRLVSRELPFATDDKARRLAISNVEELLRTRLVGQGHLTEAIASLMRKKLSYPHEPLVLHFAGDNGVGKTHTARLLSLATSLRCANSRGRQCDSGDNMLVISGTGFGGLEGRDGLNLLVRKITEHQRKYPHGIVLLDDLNAMHPSLVALLAPLFGRADRFEGQAADLPSLKELTVIVTTDFGKQGRTFGKSVVEVEKMVRMEFNSLYGSFVPAFVRTLAFAAFSKRSAEEMVRTTVITLPCTAYRYGFAGPNAYGGGVVASSIDDVAVSFLVERYREVWEGRENGHALRRAVEDSLLSLLLKYFDEHGHDRRVWARFHLDEKVGEIVLDAGADPHSMNDL
Protein: N-acetyltransferase domain-containing protein (A5Z2W6)
Organism: Caenorhabditis elegans
Interaction partners:
- VWFA domain-containing protein
- C-type lectin domain-containing protein
- Fibrinogen C-terminal domain-containing protein
Sequence:
MELVINPPQQVFDQLIDLAAETNGWAHQAYDYRFYSTSYDGYWFVTVIDKEKEEFNNLVAGVSLARWDAKNDGPLYSIGLYYCKEEYRGKGYGKQVFDAIMDIVGDDTCALFSAVNMSKKYSEVFGFDNLSPYWIMEAKIDPSKFKIPKNLDSDVIVKDWKEVDEAQLEAYDLTICSRNRKKIMRNWFQQDEVYTRVAIDSNQKIVGYCTIRVVNLNRIRASPFYAENGEIAAKLLAETVKIIPNFEKFDQLKFYYPSVNKEMESLLPKFLPADGYTVKENNRVQFTKNFIKSRDEAVYSVSCTTHQYI
Protein: tRNA ligase 1 (AtRLG1) (AtRNL) (AtRlg1p) (EC 6.5.1.3) (Protein AT.I.24-9) (Q0WL81)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential component of stress-response pathways entailing repair of RNA breaks with 2',3'-cyclic phosphate and 5'-OH ends. Tri-functional enzyme that repairs RNA breaks with 2',3'-cyclic-PO(4) and 5'-OH ends. The ligation activity requires three sequential enzymatic activities: opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester (CPDase activity), phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP (kinase activity) and ligation of the two tRNA halves in an ATP-dependent reaction (ligase activity). Deficient in transferring AMP to pRNA(OH) to form AppRNA(OH) but proficient at sealing pre-adenylylated AppRNA(OH). CPDase and kinase reactions are almost insensitive to RNA length, whereas the ligase activity decreases with shorter RNA size. Can also splice DNA ended by a single 3'-terminal ribonucleoside 2',3'-cyclic-PO(4). Binds to mRNA, mature and immature. Exhibits tRNA ligase activity in vitro. Required for the splicing of precursor tRNA molecules containing introns. Can circularize an intron cleaved from a pre-tRNA by splicing endonuclease in vitro. Seems not involved in unfolded protein response (UPR) in the endoplasmic reticulum. Involved in auxin signaling and polar transport during organ morphogenesis.
Subcellular location: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:20844078}. Note=Associated on polysomes. {ECO:0000269|PubMed:20844078}.
Interaction partners:
- Disease resistance protein ADR1
- Cyclic phosphodiesterase
- Toll/interleukin-1 receptor-like protein
- Probable disease resistance protein At5g04720
- Disease resistance protein RBA1
- Probable disease resistance protein At4g33300
- Probable disease resistance protein RPP1
- Cytochrome b
- Putative disease resistance protein At5g47280
- ATP synthase subunit a.
Sequence:
MDAPFESGDSSATVVAEAVNNQFGGLSLKESNTNAPVLPSQTTSNHRVQNLVWKPKSYGTVSGSSSATEVGKTSAVSQIGSSGDTKVGLNLSKIFGGNLLEKFSVDKSTYCHAQIRATFYPKFENEKTDQEIRTRMIEMVSKGLATLEVSLKHSGSLFMYAGHKGGAYAKNSFGNIYTAVGVFVLSRMFREAWGTKAPKKEAEFNDFLEKNRMCISMELVTAVLGDHGQRPLDDYVVVTAVTELGNGKPQFYSTSEIISFCRKWRLPTNHVWLFSTRKSVTSFFAAFDALCEEGIATSVCRALDEVADISVPASKDHVKVQGEILEGLVARIVSSQSSRDMENVLRDHPPPPCDGANLDLGLSLREICAAHRSNEKQQMRALLRSVGPSFCPSDVEWFGDESHPKSADKSVITKFLQSQPADYSTSKLQEMVRLMKEKRLPAAFKCYHNFHRAEDISPDNLFYKLVVHVHSDSGFRRYHKEMRHMPSLWPLYRGFFVDINLFKSNKGRDLMALKSIDNASENDGRGEKDGLADDDANLMIKMKFLTYKLRTFLIRNGLSILFKDGAAAYKTYYLRQMKIWGTSDGKQKELCKMLDEWAAYIRRKCGNDQLSSSTYLSEAEPFLEQYAKRSPKNHILIGSAGNLVRTEDFLAIVDGDLDEEGDLVKKQGVTPATPEPAVKEAVQKDEGLIVFFPGIPGSAKSALCKELLNAPGGFGDDRPVHTLMGDLVKGKYWPKVADERRKKPQSIMLADKNAPNEDVWRQIEDMCRRTRASAVPIVADSEGTDTNPYSLDALAVFMFRVLQRVNHPGKLDKESSNAGYVLLMFYHLYEGKNRNEFESELIERFGSLIKMPLLKSDRTPLPDPVKSVLEEGIDLFNLHSRRHGRLESTKGTYAAEWTKWEKQLRDTLVANSEYLSSIQVPFESMVHQVREELKTIAKGDYKPPSSEKRKHGSIVFAAINLPATQVHSLLEKLAAANPTMRSFLEGKKKSIQEKLERSHVTLAHKRSHGVATVASYSQHLNREVPVELTELIYNDKMAALTAHVGSVDGETVVSKNEWPHVTLWTAEGVTAKEANTLPQLYLEGKASRLVIDPPVSISGPLEFF
Protein: Protein SFK1 (Suppressor of four kinase protein 1) (P35735)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May control the production of phosphatidylinositol 4-phosphate (PI4P) by the STT4 PI 4-kinase. Mediates proper localization of STT4 to the plasma membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12015967, ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:12015967, ECO:0000269|PubMed:14562095}.
Interaction partners:
- Phosphatidylinositol 4-kinase STT4
- Cargo-transport protein YPP1
- Protein EFR3
- L-2-aminoadipate reductase
Sequence:
MIQFKSPGNWLFIVPWIAFIPWYGMLIAMLICWASQGHPIYWFMHSEQFPVYISDIGATNLRPLFISCAGWQGLGYVITVALEFFQRSGYLPFQLKKKDPSISDSTSYAEKLHSGKYLMPPYYTKDERNLIFAAFVLGSIGELALLFSSIFSTALYHRVHIAMVSVFVVFMFLSTCCLIAEYFLMGRHYASVHPLASPHFNPQSSEKSFNQDYNTVDELPWYKWKGHVWNKFTISATLKVIWLTLAVVWAICFGAINDRSKSACFEWLLAFWFGIIFMILSADFYLGGRYRQSRYFNHVESFSGYYKYDKALGLYHSEDVLPSDDNAGVIATETASSNIYNNSSSNESIQVVV
Protein: Ladybird early (MIP30310p) (Q7KS77)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MLCPPTMRPASPAESEISVGGAPSPLPTQHHTHPHSHPHPLQHPRASTIDLLQQQQLLMQHHAAAAAAAAAAASGLTRSAVGNLPEDYFHPLKRLRMSSSSSEPRDHTPSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESVSPPPNANLLAPPASRPIAPSGGLLQPRTEPLDVHPAAAAAMLLPSGQIVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEELKKDFDSVKVFSAHKSFLENVNDLSILKKKPMHESDMVGLAAAAAAAGMVVPVPGSVPMGGAPPK
Protein: Regulatory-associated protein of TOR 1 (Protein RAPTOR 1) (Protein RAPTOR 1B) (AtRaptor1b) (Q93YQ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable component of the plant TOR kinase pathway that recruits substrates for TOR. Modulates plant cell growth and regulates the activity of ATPK1 kinase in response to osmotic stress.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:27545962}.
Interaction partners:
- Serine/threonine-protein kinase TOR
- Non-functional target of rapamycin complex subunit LST8-2
- Target of rapamycin complex subunit LST8-1
- PP2A regulatory subunit TAP46
- Probable ethanolamine kinase
- Serine/threonine-protein kinase AtPK1/AtPK6
- Autophagy-related protein 101
- Peptidyl-prolyl cis-trans isomerase FKBP12
- Autophagy-related protein 11
- Uncharacterized protein
Sequence:
MALGDLMVSRFSQSSVSLVSNHRYDEDCVSSHDDGDSRRKDSEAKSSSSYGNGTTEGAATATSMAYLPQTIVLCELRHDASEASAPLGTSEIVLVPKWRLKERMKTGCVALVLCLNITVDPPDVIKISPCARIEAWIDPFSMAPPKALETIGKNLSTQYERWQPRARYKVQLDPTVDEVRKLCLTCRKYAKTERVLFHYNGHGVPKPTANGEIWVFNKSYTQYIPLPISELDSWLKTPSIYVFDCSAARMILNAFAELHDWGSSGSSGSSRDCILLAACDVHETLPQSVEFPADVFTSCLTTPIKMALKWFCRRSLLKEIIDESLIDRIPGRQNDRKTLLGELNWIFTAVTDTIAWNVLPHELFQRLFRQDLLVASLFRNFLLAERIMRSANCNPISHPMLPPTHQHHMWDAWDMAAEICLSQLPQLVLDPSTEFQPSPFFTEQLTAFEVWLDHGSEHKKPPEQLPIVLQVLLSQCHRFRALVLLGRFLDMGSWAVDLALSVGIFPYVLKLLQTTTNELRQILVFIWTKILALDKSCQIDLVKDGGHTYFIRFLDSSGAFPEQRAMAAFVLAVIVDGHRRGQEACLEANLIGVCLGHLEASRPSDPQPEPLFLQWLCLCLGKLWEDFMEAQIMGREANAFEKLAPLLSEPQPEVRAAAVFALGTLLDIGFDSNKSVVEDEFDDDEKIRAEDAIIKSLLDVVSDGSPLVRAEVAVALARFAFGHKQHLKLAAASYWKPQSSSLLTSLPSIAKFHDPGSATIVSLHMSPLTRASTDSQPVARESRISSSPLGSSGLMQGSPLSDDSSLHSDSGMMHDSVSNGAVHQPRLLDNAVYSQCVRAMFALAKDPSPRIASLGRRVLSIIGIEQVVAKPSKPTGRPGEAATTSHTPLAGLARSSSWFDMHAGNLPLSFRTPPVSPPRTNYLSGLRRVCSLEFRPHLLGSPDSGLADPLLGASGSERSLLPLSTIYGWSCGHFSKPLLGGADASQEIAAKREEKEKFALEHIAKCQHSSISKLNNNPIANWDTRFETGTKTALLHPFSPIVVAADENERIRVWNYEEATLLNGFDNHDFPDKGISKLCLINELDDSLLLVASCDGSVRIWKNYATKGKQKLVTGFSSIQGHKPGARDLNAVVDWQQQSGYLYASGETSTVTLWDLEKEQLVRSVPSESECGVTALSASQVHGGQLAAGFADGSLRLYDVRSPEPLVCATRPHQKVERVVGLSFQPGLDPAKVVSASQAGDIQFLDLRTTRDTYLTIDAHRGSLTALAVHRHAPIIASGSAKQLIKVFSLQGEQLGIIRYYPSFMAQKIGSVSCLTFHPYQVLLAAGAADSFVSIYTHDNSQAR
Protein: Kinetoplastid kinetochore protein 12 (Q580F6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Clathrin heavy chain
- Clathrin coat assembly protein, putative
- Polyubiquitin, putative
Sequence:
MMASAPMAGDYQTRSAAISEKMNTVQLRRRIVEDLRRRAESLSGQLRQRQQDLQRLIDEFTQKKASQEAKISEKRRCELGQKELLDSLLKEEERLTNVQKDYAESIGKLQQEVAQRQATVGKVSQAREELTRVKMMLEEKDREILALERNVEKVRLNAKRRHEQFEMQLPDVTLPCLGEVERGGLEETASESILLIGDPS
Protein: Uncharacterized protein (Q382K4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRIVRIQFLLPSEADALIELQVTVASLVLAVIVFVCMRYIRCLWTSHTPKASAAPSVEEGNADDNGNGIGLLMLFPRLPPLHEVTTTLERRLPAILQPKLGGEGGTIGPVFFREHIVMREMFQNQSYRASSPRSTQSSHRGEQSPLSRREPSRTVSVPSAVSESFARLPMSRNASPTVQEDGRNSSRKRVGQRNADTAEATTVVDAPAVRRDDNRRIFGSLGRVPVKCSDVAPTQDTVRNGSDWKWLAQQKAAQLMNAPSTLSVVHGVCDVRYIKVYDSGDEGQSGGDGNHRGGILLRVRSRAITASVLLQLVVKCGLIQYTTTSPPVFSSNINNNGSDSSNYNEPSTAMRSKDDSHECTDHVGEEDTDPRKHEHTSACVFLFDSHTLTGRLLRGLFGFTAVVLHALHTVIALLIKYVARGSGEDINSDSAGGQVRLFISPFCSKILLQSAADCMNEWIELRAAGSPEVCVSDIAIALLLGAMRRQRVKHRRRLTLRQKAVLTGNRGALPEALSRTLLRCCRFLERCCAISCYLAGSPRLADERIRHPLHPRPHERVAETMFTAVVEVEAMSLSEYGDTNPPNPKDWVERVLKCTECRLLTAGTCRQPLRTSMDIVTYSGMRDRATSCHFCCEQMEALYCIEPLYHFPACLPVVESSPPVQCHAITECGDALYQTVWLPVKECPGDEFLEDLAEELLVMTKNILKMCTDDVLEVLRLTHGR
Protein: Bistable UV pigment (Q764P5)
Organism: Lethenteron camtschaticum (Japanese lamprey) (Lampetra japonica)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}.
Interaction partners:
Sequence:
MENLTSLDLLPNGEVPLMPRYGFTILAVIMAVFTIASLVLNSTVVIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFFGIAALCTIAVIAVDRFVVVCKPLGTLMFTRRHALLGIAWAWLWSFVWNTPPLFGWGSYELEGVRTSCAPDWYSRDPANVSYITSYFAFCFAIPFLVIVVAYGRLMWTLHQVAKLGMGESGSTAKAEAQVSRMVVVMVVAFLVCWLPYALFAMIVVTKPDVYIDPVIATLPMYLTKTSTVYNPIIYIFMNRQFRDCAVPFLLCGRNPWAEPSSESATAASTSATSVTLASAPGQVSPS
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0U1RQT7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRPSQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEANCLKMLNLWCCCFFKRKRKKTAQRHK
Protein: Inositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Skeletal muscle and kidney-enriched inositol phosphatase) (Q8C5L6)
Organism: Mus musculus (Mouse)
Function: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (By similarity). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:22247557, ECO:0000269|PubMed:22751929}. Cytoplasm {ECO:0000250|UniProtKB:Q9BT40}. Note=Following stimulation with EGF, translocates to membrane ruffles. {ECO:0000250|UniProtKB:Q9BT40}.
Interaction partners:
- Inositol polyphosphate-5-phosphatase A.
- Inositol polyphosphate multikinase
- Kinase
- Inositol-trisphosphate 3-kinase C
- Inositol-trisphosphate 3-kinase A
- Inositol-tetrakisphosphate 1-kinase
- Multiple inositol polyphosphate phosphatase 1
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
- Inositol polyphosphate 1-phosphatase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Sequence:
MQHGDRNTPGYREGIMSAVSLRRPSAPKGFALSVHVVTWNVASAAPTVDLSDLLQLNNQDLNLDIYIIGLQEMNFGIISLLSDAAFEDPWSSLFMDMLSPLNFVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSTPTGLYGYWGNKGGVNVCLKLYGYYVSIINCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQESITRKYYKELWEKDQLFIAKKNDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPSQASPLASSVPTSYFLLTLKNYVSHMAYSISDHKPVTGTFDLELNPLMSVPLITMMPEHLWTMENDMLISYTSTPEFLSSSWDWIGLYKVGMRHINDYVAYVWVGDNQVSYGNNPNQVYINISAIPDTEDQFLLCYYSNNLHSVVGISQPFKIPIRSFLREDTLYEPEPQI
Protein: Late cornified envelope protein 3A (Late envelope protein 13) (Q5TA76)
Organism: Homo sapiens (Human)
Function: A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.
Interaction partners:
- Late cornified envelope protein 3D
- Small proline-rich protein 2A
- Late cornified envelope protein 2A
- Late cornified envelope protein 1C
- Late cornified envelope protein 2B
- Late cornified envelope protein 1A
- Late cornified envelope protein 1B
- Late cornified envelope protein 1F
- Late cornified envelope protein 2C
- Late cornified envelope protein 3B
Sequence:
MSCQQNQQQCQPPPKCPAKSPAQCLPPASSSCAPSSGGCGPSSERSCCLSHHRCRRSHRCRCQSSNSCDRGSGQQGGSSSCGHSSAGCC
Protein: Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (P40160)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the final endonucleolytic cleavage of 20S pre-rRNA at site D in the cytoplasm, converting it into the mature 18S rRNA. Involved in normal export of the pre-40S particles from the nucleus to the cytoplasm. No longer associates with pre-40S subunits in RPS19 disruptions, suggesting it acts after the ribosomal protein in 18S rRNA maturation.
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Interaction partners:
- Small ribosomal subunit protein eS6A
- Dimethyladenosine transferase
- Small ribosomal subunit protein eS19B
- Small ribosomal subunit protein uS10
- Essential nuclear protein 1
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS11A
- Small ribosomal subunit protein eS1B
- Small ribosomal subunit protein eS8A
- Small ribosomal subunit protein eS21B
Sequence:
MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLSLISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSNDEAEEENGEGDYSEEDEYYDSELDNESSEDDSEDAQEEENERIIEALSSGVENLKMDKLGNYILE
Protein: 1-aminocyclopropane-1-carboxylate oxidase homolog 3 (Q8H1S4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Katanin p80 WD40 repeat-containing subunit B1 homolog KTN80.4
Sequence:
MEMMKIDPLFDRASELKAFDETKTGVKGLVDSGVSQVPRIFHHPTVKLSTPKPLPSDLLHLKTIPTIDLGGRDFQDAIKRNNAIEEIKEAAAKWGFFQVINHGVSLELLEKMKKGVRDFHEQSQEVRKEFYSRDFSRRFLYLSNFDLFSSPAANWRDTFSCTMAPDTPKPQDLPEICRDIMMEYSKQVMNLGKFLFELLSEALGLEPNHLNDMDCSKGLLMLSHYYPPCPEPDLTLGTSQHSDNSFLTVLLPDQIEGLQVRREGHWFDVPHVSGALIINIGDLLQLITNDKFISLEHRVLANRATRARVSVACFFTTGVRPNPRMYGPIRELVSEENPPKYRETTIKDYATYFNAKGLDGTSALLHFKI
Protein: Formin-1 (Limb deformity protein) (Q05860)
Organism: Mus musculus (Mouse)
Function: Plays a role in the formation of adherens junction and the polymerization of linear actin cables.
Subcellular location: Nucleus. Cytoplasm. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton. Note=Isoform 2 localizes to microtubules.
Interaction partners:
- Protein spire homolog 1
- Protein spire homolog 2
- Profilin-4
- Profilin-1
- Profilin-2
- Profilin
- Profilin-3
Sequence:
MEGTHCTLQLHNPIAELCYISFYLPKGEVRGFSYKGTVTLDRSNNAFHNCYQVREGPDITSLSQQPNEHPGDIFFKQTPTKNILTELYKLTAEKERLLDSLLRSDNILGVSMGSQEGKLQELSVILATGDEYFQSAGNWRRELPVSSLIRRSTQENKKPRRSGRRRESPEELRQKRTRRKGRGCQESAFQMGKDQVCSSSSLSFRARPNLRLLEERGNLVPRGTLTSSLRRRESCPANILRTPDADLAFGNSGRTSEDTDLEGPLSPDSSPTEVGDADVGGQLKSSHQQEPPQPNVSESHGKHAGAERWSSRTRKSKSLERTCSKKPVSKVVAKIQEPSAPVKRIVRAHHDGKGRVAYGPETQTEFIPKADFLTLPGGETETHSSGRLEEEQPGIKSLRSSAPERASITKEPASTEAAVNKVLRKVIESEKLDEATEGKRLGFSLNTRATHTFPETRSQRKAGLPQSGHKFLLLDLPHTVGPDSPQPKCDEKKPTPQVPTALGMVFNNSSPQSSAHKRLSPVPSPLSPRCPSPQQHHRILLLPPLPSEGEVVFNEYPSRKNDVSSGFPSADTLEPSSTTKVTETKGASPTSLRASQTWLVSEEASEKGLGPEKITAPPQHQLPPGIASEGFPCDNFKEQTAKDLPNKDGGVWVPGYRAGPPCPFLLHEEKEKTSRSELYLDLNPDQSPTEQDDRTPGRLQAVWPPPKTKDTEEKVGLKYTEAEYQAAILHLKREHKEEIETLQAQFELKTFHIRGEHALVTARLEEAIENLKQQLGKRREGCEEMRDVCISTDDDCSPKAFRNVCIQTDRETFLKPCDAESKATRSSQIVPKKLTISLTQLSPSKDSKDIHAPFQTREGTSSSSQHKISPPAPPTPPPLPPPLIPPPPPLPPGLGPLPPAPPIPPVCPVSPPPPPPPPPPTPVPPSDGPPPPPPPPPPLPNVLALPNSGGPPPPPPPPPPGLAPPPPPGLSFGLSSSSSQYPRKPAIEPSCPMKPLYWTRIQINDKSQDAAPTLWDSLEEPHIRDTSEFEYLFSKDTTQQKKKPLSEAYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFTVDDSVVDLETLAALYENRAQEDELTKIRKYYETSKEEDLKLLDKPEQFLHELAQIPNFAERAQCIIFRAVFSEGITSLHRKVEIVTRASKGLLHMKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSRDNGMNLVDYVVKYYLRYYDQCKHHDQEASCRGKDLFSLYFHIAVHPQRKSGLELKQEAGTDKSVFPLPEPQDFFLASQVKFEDLLKDLRKLKRQLEASEQQMKLVCKESPREYLQPFKDKLEEFFKKAKKEHKMEESHLENAQKSFETTVGYFGMKPKTGEKEVTPSYVFMVWFEFCSDFKTIWKRESKNISKERLKMAQASVSKLTSEKKVETKKINPTASLKERLRQKEASVATN
Protein: Putative serine esterase Rv1835c (EC 3.1.1.-) (P9WIQ9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv1836c
Sequence:
MTRRGGSDAAWYSAPDQRSAYPRYRGMRYSSCYVTMRDGVRIAIDLYLPAGLTSAARLPAILHQTRYYRSLQLRWPLRMLLGGKPLQHIAADKRRRRRFVASGYAWVDVDVRGSGASFGARVCEWSSDEIRDGAEIVDWIVRQPWCNGTVAALGNSYDGTSAELLLVNQHPAVRVIAPCFSLFDVYTDIAFPGGIHAAWFTDTWGRYNEALDRNALHEVVGWWAKLPVTGMQPVQEDRDRSLRDGAIAAHRGNYDVHQIAGSLTFRDDVSASDPYRGQPDARLEPIGTPIESGSINLISPHNYWRDVQASGAAIYSYSGWFDGGYAHAAIKRFLTVSTPGSHLILGPWNHTGGWRVDPLRGLSRPDFDHDGELLRFIDHHVKGADTGIGSEPPVHYFTMVENRWKSADTWPPPATTQSYYLSADRQLRPDAPDCDSGADEYVVDQTAGTGERSRWRSQVGIGGHVCYPDRKAQDAKLLTYTSAPLDHPLEVTGHVVVTLFITSTSSDGTFFVYLEDVDPRGRVAYITEGQLRAIHRRLSDGPPPYRQVVPYRTFASGDAWPLVPGEIARLTFDLLPTSYLFQPGHRIRIAIAGADASHFAILPGCAPTVRVYRSRMHASRIDLPVIQP
Protein: Transmembrane protein (Q9FY88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ubiquitin-related modifier 2
- Las1-like family protein
- Protein ROOT INITIATION DEFECTIVE 3
- Small ubiquitin-related modifier 5
- Protein VTE6, chloroplastic
- Small ubiquitin-related modifier 1
- Small ubiquitin-related modifier 3
- Acid phosphatase/vanadium-dependent haloperoxidase-related protein
- Putative small ubiquitin-related modifier 8
- Putative small ubiquitin-related modifier 7
Sequence:
MATEHSGLEDQESQPSQVAPGFVGAIEEQYKKLRDHAEAYPYVWGSYTVVYGGLFLWTAYRWRKLRRTEDRVRGLQTKLRKLVENEQAAVTASKSAQSVDKSSSIPDKKTS
Protein: rRNA biogenesis protein RRP5 (Ribosomal RNA-processing protein 5 homolog) (Q9VC94)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:35628496}.
Interaction partners:
- LD10780p
- Uncharacterized protein
- Lethal
- Nucleolar protein 6
- LD38375p
- LD41718p
- KRR1 small subunit processome component homolog
- FI12406p
- Small ribosomal subunit protein uS17
- Nucleolar protein 14 homolog
Sequence:
MVPNEKSFPRGGTIHSEVKTDDVSLNIVFGASQKKVKKAPKVKENLLSYETEEQNGQLEAFSAETLNMDTLQEDMLVMGVVKELTATALQIALPGRMFARTLVADISDAYTRVAKAAMSGDTSEYHDLTELFQLGRIVYGKAIKTEKLDTGRVSLLLSLKPADVHGNLHHKSIKKGFIFSGAVAEALEHGYVIESGVQGLQAFVPCEKPAQKLHVGQLAFLKVKTVHHDTHQSTCTCVQVEQDQLRIKSQNETNLDYILPGSIVKFKVAKHLKDGLKGSIMNESFSAYVNEHHLANALDTLDAYELNEDYNARVLYVMPLTKLVYLTLNLDIKTGAAVAKDQDEEEQEVEPIKVGSVVEKAKVLRLGSGGVVLLLNKKLKGIISYGSIRGNFKGNYDKDEVLSKYGRKTKHKVRILGYDVIESLYYCSDDPNVVNEKLFCLEDINAGDLVTAKIFKKDDKIKGWSVRIGKVNGILEQFYLAPNVRYDVGQSLKCRVLEVNAERKICYVSNRAEYLGKGIKILTDYASAHVGNVYMGTVVRCEDTYVLVKFGNGIKGVLHRQNLKENSSFFEGQTTKFRILTRNKDQITLTLPEDKFQLGEICPVEITNALDAGLEVKITFAAEDDEEDEDGNPKLEEFVGLIPLRLLSDHLELLHAQMRVHPAGSYTDAACIMQNIFSLRDVPYFSGQLTKDWQSVQVGDIIRSYVKHATDQVVDLMVCVRNYNKPVKVHVKMLRLNAVKNAPVELVPEQLLWVKVLSKEVETKTLTVSAKLTDVWSGDLSDTAKLVEGYLNEVAQIKAGLEEASAPISKYSVGEKINVVFKGIDATTNDWVYTVEGNGKVSALLLSSLVGTAKAPEMGSKHEAVILWIEYSSDVLLISNKKLDIAHISPSGELSTNLIGKAGMKAKVLLKLESVAVCSLKKGTNPLVICPIRLHPNDIENSGSAELRQGDFCNIAFIHDKLHIAVPETVWRLWRGVKRTAGTEVAPVKAKKAKVEESPKQKKTTIEETSAQKKVKAKAKVETKTEAKAIPTKRKAEVVEKITNGQKKTQPLTNGIVKEKPKQNGKLFFEDKTPAKNAKSETPKSNGAEGKSRLPGVSSFWEDDVNQSKEGSSDEDEELNVAETQKNAAKKKRLSAKEKAKAEIKEEQRLREIEERNADPKARLETIDQYERLVIAQPNNSISWLKYIAFLLSNTEIEKARALARRAISTISFRETQELRNMWSALLNMELVYSNNFDDVLKEALNCNDPLEIYISVVDILKKNKRKDRLSSVLTTVLNKFKTELRVWPVAAEAYFWLGKSDQVHNLLQRALRALPNQEHIPCIVSFAKLYAKHDNNDMAQTLLDDVVTSYPKRIDIWSVYVDMLIKAGLIDSARNVLERAVVQKLKPNKMQVIYKKYLQLEENHGTDATVAKVKQQAEQWVKNYAKTVK
Protein: Inorganic pyrophosphatase 1 (AtPPsPase1) (PPi phosphatase 1) (Pyrophosphate-specific phosphatase 1) (EC 3.6.1.1) (Protein PHOSPHATE STARVATION-INDUCED GENE 2) (AtPS2) (Q67YC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the specific cleavage of pyrophosphate.
Interaction partners:
- Pyridoxal 5'-phosphate synthase-like subunit PDX1.2
- Inorganic pyrophosphatase 2
- Putative glycerol-3-phosphate transporter 1
- Pyridoxal 5'-phosphate synthase subunit PDX1.1
- Pyridoxal 5'-phosphate synthase subunit PDX1.3
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
- Thiamine phosphate phosphatase-like protein
- Pyridoxal kinase
- Pyridoxine/pyridoxamine 5'-phosphate oxidase 2
- Pyridoxal reductase, chloroplastic
Sequence:
MAYNSNSNNNNNNIVVVFDFDKTIIDVDSDNWVIDELGFTDLFNQLLPTMPWNTLMDRMMKELHDQGKTIEEIKQVLRTIPIHPRVVPAIKSAHDLGCELRIVSDANMFFIETIVEHLGISELFSEINSNPGYVDERGTLKISPYHDFTKSPHSCSCGTCPPNMCKGLIIERIQQSLAKEGKKKMIYLGDGAGDYCPSLKLNTEDYVMPRKNFPVWDLISQNPMLIKAAIREWTDGQSMEMILIGTIEEIRLEEEKEKMLTSAENNCKMQTISIGINNVHHEPILPRALRVSQSS