wanglab/gogpt-training-data huggingface dataset:
Protein: Lipase lipl-3 (EC 3.1.1.-) (Lipase-like 3) (O16956)
Organism: Caenorhabditis elegans
Function: Lipase that, together with lipl-1, plays a role in the response to nutrient deprivation by controlling lipid metabolism. Specifically, involved in the breakdown of lipids during lipophagy, a process during which lipids contained in lipid droplets that have been delivered to lysosomes by autophagy are degraded.
Subcellular location: Secreted {ECO:0000269|PubMed:23604316}. Lysosome lumen {ECO:0000269|PubMed:23604316}. Note=Secreted into the intestinal lumen. {ECO:0000269|PubMed:23604316}.
Interaction partners:
- Fatty acid synthase
- Helix-loop-helix protein 30
- Protein mxl-3
- Medium-chain acyl-CoA ligase ACSF2
Sequence:
MCSSLCALLLVILAVHNVHAKSDPELHMTTPQIIERWGYPAMIYSVTTDDGYILELHRIPHGKTNVTWPNGKQPVVFMQHGLLCASTDWTMNLPEQSAAFIFADAGFDVWLGNMRGNTYSMKHKNLKASHSDFWEWSWDEMATYDLPAMIDKVLEVTGQESLYYMGHSQGTLTMFSHLSKDDGIFAKKIKKFFALAPVGSVKDIKGFLSFFAHYFSLEFDGWFDVFGAGEFLPNNWAMKLAAKDICGGLKIESDLCDNVCFLIAGPESDQWNSTRVPVYASHDPAGTATQNIVHWIQMVRHGGVPAYDWGSKENKKKYGQANPPEYDFTAIKGTQIYLYWSDADWLADKTDITNYLLTRLNPAIIAQNNYFTDYNHFDFVFGLRAPNDIYLPIVDICTKDYNGK
Protein: Small ribosomal subunit protein eS1y (40S ribosomal protein S3a-2) (Q42262)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03122}.
Interaction partners:
- Small ribosomal subunit protein uS17x
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Large ribosomal subunit protein eL8z
- Small ribosomal subunit protein eS26y
- Large ribosomal subunit protein uL4z
- Small ribosomal subunit protein uS2z
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein uS12y
- Probable elongation factor 1-gamma 2
Sequence:
MAVGKNKRISKGRKGGKKKAVDPFSKKDWYDVKAPGSFTNRNVGKTLVSRTQGTKIASEGLKHRVFEVSLADLQNDEDNAYRKIRLRAEDVQGRNVLTQFWGMDFTTDKLRSLVKKWQTLIEAHVDVKTTDGYTLRMFCIAFTKRRANQVKRTCYAQSSQIRQIRRKMSEIMVKEASSCDLKELVAKFIPEAIGREIEKATQGIYPLQNVFIRKVKILKAPKFDLGKLMEVHGDYTAEDVGVKVDRPADETMVEEPTEIIGA
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (NADH-ubiquinone oxidoreductase B22 subunit) (Q02369)
Organism: Bos taurus (Bovine)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:10852722, ECO:0000305|PubMed:18721790}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Interaction partners:
- Cytochrome b-c1 complex subunit 9
- NADH dehydrogenase iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 8, mitochondrial
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase flavoprotein 1, mitochondrial
Sequence:
MAFLSSGAYLTHQQKVLRLYKRALRHLESWCIHRDKYRYFACLLRARFDEHKNEKDMVKATQLLREAEEEFWHGQHPQPYIFPESPGGTSYERYECYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVKQLQEETPVGGPRTEALPPARKQGDLPPLWWHIVTRPRERPM
Protein: Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) (P40935)
Organism: Mus musculus (Mouse)
Function: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor. Other substrates include phenylethanolamine, octopamine and normetanephrine (By similarity).
Interaction partners:
- Dopamine beta-hydroxylase
- Catechol O-methyltransferase
- Transmembrane O-methyltransferase homolog
- Amine oxidase [flavin-containing] A
- Amine oxidase [flavin-containing] B
- Tyrosine 3-monooxygenase
- Aromatic-L-amino-acid decarboxylase
- Phenylalanine-4-hydroxylase
Sequence:
MNGGSDLKHATGSGSDPKHAAEMDPDSDAGQVAVALAYQRFEPRAYLRNNYAPPRGDLSNPDGVGPWKLRCMAQVFATGEVSGRVLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELGLWLREEPGAFDWSVYSQHACLIEDKGESWQEKERQLRARVKRVLPIDVHKPQPLGTPSLVPLPADALVSAFCLEAVSPDLTSFQRALHHITTLLRPGGHLLLIGALEESWYLAGEARLSVVPVSEEEVREALVLGGYEVRELRTYIMPAHLCTGVDDVKGIFFAWAQKMEVQV
Protein: Osteocalcin (Bone Gla protein) (BGP) (Gamma-carboxyglutamic acid-containing protein) (P02818)
Organism: Homo sapiens (Human)
Function: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Subcellular location: Secreted {ECO:0000269|PubMed:6967872}.
Interaction partners:
- Runt-related transcription factor 2
- Osteopontin
- SPARC
- G-protein coupled receptor family C group 6 member A
- Integrin-binding sialoprotein
- Vitamin K-dependent gamma-carboxylase
- Parathyroid hormone
- Matrix Gla protein
- Bone morphogenetic protein 2
- Fibronectin
Sequence:
MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGPV
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A8I6AJE4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
Interaction partners:
Sequence:
MSLQSFGRASTVTLPEALLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGISGLPPMNLSTTIPGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYIWQREGLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEVINLVGQTSENTPTTVSQDVEEKLPRAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSMHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPDFLDSSGLFSESSGTSSPSPSPRASNHSLNSSSSASKAGTSPSLEPDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPPLTSVYMHTQTCTHMYNGSTQLCHLAMEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKRHHYRELPLEVQETLGSIPDDFVRYFTSRFPHLLSHTYRAMELCRHERLFQTYYWHEPTEAQPPGIPDAL
Protein: Uncharacterized protein, isoform A (Uncharacterized protein, isoform B) (Q9I7L9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Neuropathy target esterase sws
- Lysophosphatidylcholine acyltransferase
- Lysophospholipid acyltransferase 5
- LD22655p
- BcDNA.GH02384
- Phospholipase
- phospholipase A2
- BOS complex subunit TMEM147
Sequence:
MRLKSGVLSLLLLTTFLALGECFWPFSKWHGRNDNPSAPPEPKLSPVIFVPGDGGSQMDARLNKPNSPYLICQKTHDWYNLWLDLEQLVIPMVYCWIDNVKLYYDKVTRTTHNTPGVETRIPGWGNPEVVEWIDPTKNSAGAYFKDIANELVKLGYIRKQNIHGAPYDFRKAPNENQQFFIDLKQLVEDSYEANNQSAVTFISHSMGSLMTLVFLQEQTLQWKAKYVKRMISLAGVWAGSFKAVKVFAMGDDLDSFALSAKILKAEQITHPSTAWLLPSPLFWKPSEVLAMTPSRNYTMAQLEEFFKDLDYMTGWEMRKDTIRYNRNFDPPNVELHCLYGEGIDTVERLQYKKSDISGETPKLIMGLGDGTVNQRSLRACKYWAGYSKAPINTLALQNVDHLHILSNPDVLKYIRTVMQQP
Protein: Transient receptor potential channel (A5JYU8)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MMSDDMLDENDENFACQDVDEIIIYVPEFAGYREVNIDTAVSVCPTPIQQARRESSCRNLEMRRRFEKLRREKKEEKKLLADDEKDFDEDDDVFEDGEGLQMRTFQPNASIRDENGSMPSLLPRTAPIKKTRKHRRRRSGSFTGGVYPRKGHRNRSLLGHAIPPPNVHSADWRDMLAITDNKDDKLMKTMQAIKDAIRKQEEAEMKLLGQRKVREGVVCFL
Protein: Vomeronasal 2, receptor 83 (A0A3B2WB78)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLFSCLFFTWLLQMPTLIWTFATSSCLSESEYLLHHDGTVVIGAFFPILKSLPVSETIDWKTLSFDIDNVLEMNVHNYQLVLTMLFAINEINLNSHILPNTSLGLEIYNVPYLQRNALRNVFYWLTGLSTFIPNYSCRKNSKSAATLTGILWKTSENIGTVLDLYKFPQITFGPFDHDQIDRKQFPSLYQVAPKDTSLLSGIASLMLHFNWTWVGLLSTDDHRGAQFLSDLRKVFHY
Protein: Homeobox protein ceh-28 (NK-2 homeodomain factor CEH-28) (G5EE18)
Organism: Caenorhabditis elegans
Function: Probable transcription factor that regulates neuronal differention, including synapse assembly of the cholinergic motor neuron M4. Activates expression of growth factor, neuropeptide and transcription factor genes, such as TGF-beta dbl-1, FMRFamide-like flp-5 and transcription repressor zag-1, in the M4 neuron. Required for pharynx peristalsis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682}.
Interaction partners:
- Zinc finger E-box-binding homeobox protein zag-1
- FLYWCH-type domain-containing protein.
Sequence:
MQSTQISSTTVILPSEVIQPPQQSAVPSEFKNTLPSRLNLFEGFDQSFSELTNPYQPVIPLMQRESLLGASSYYSSPSQNQRSYQNHRQHSNPDTINLRSQQQKRKPRVLFTQHQVNELEERFKKQRYVTATEREELAQCLGLTATQVKIWFQNRRYKCKRLAQDRTLQLSQIPFNPMFASAFPFGINSFGTAPSSSSSGS
Protein: Mannosyltransferase (EC 2.4.1.-) (Q54WW9)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363075}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363075}.
Interaction partners:
- Mannosyltransferase
- Probable Dol-P-Man:Man
- Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Uncharacterized protein
- GPR180/TMEM145 transmembrane domain-containing protein
- GPR180/TMEM145 transmembrane domain-containing protein
- Dolichyl-phosphate beta-glucosyltransferase
- Glycosyltransferase 2-like domain-containing protein
- IPT/TIG domain-containing protein
- Tiger protein C1
Sequence:
MSSKRKSQITNTNGNGSDSKKKIETEYITRNKRINDTYKSTIFVFSLFFISSILSAIYNRILDCDEYMNYWEPTHYLLYNKGLQTWEYSPTYSLRSYAYLLLHAFMGRLLNPFSNGNKIILFYLIKIGIGFFTSIAQTIFYRGVKNMFGREISRYTLIFMLFSPAFFLSGSNFLPTSFSMTTFMAAYGFWMLYQSSSTPLSALSPNESSNEAIYSVFLSATSVFMGWPFVIVLVIPIALNLMIRNGFLKVFMWALLPVIAVFIPMILIDYQYYGKWVIAIYNIIAYNFTSNHSGGSQLYGIEDWPFYFINSFVNYNIVFLFSLLTIPLLIIFRKWSGSLKNLTMVSIIYTLCPYYIWFGFMTYLPHKEERFLFVIYPFIALAGSISFYIGLNILNAIILKISGGGAGGSDIKNKKKNDDFKLKSKQQQHYNVNIYHGFVNFIKYLIIICFILLSVSRIYSTYVNYTAPFNTLTHLNNNVLLNGNISISNFSKNNNILKSNNNNNNNKSVNICIGKEWHRYPSNFFLPNDNNEIEFNLKFIESDFKGHLPKPFSTLPNGTAIIPTNMNDQNKQEFDRYIKPNECSYIIDFDSPTQNEEHYVNDTSNWKVIYSTKFLDAAASTSSLYRAFWIPKLSNQKNVYNNYYILEKI
Protein: Glutathione S-transferase alpha-2 (EC 2.5.1.18) (GST 1b-1b) (GST A2-2) (Glutathione S-transferase Ya-2) (GST Ya2) (P04903)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds.
Subcellular location: Cytoplasm.
Interaction partners:
- Cytochrome P450 1A1
- Glutathione S-transferase omega-1
- Glutathione S-transferase theta-2
- Glutathione S-transferase alpha-5
- Epoxide hydrolase 1
- Cytochrome P450 1A2
- Cytochrome P450 2E1
- Glutathione S-transferase theta-1
- Glutathione peroxidase 2
- Glutathione peroxidase 1
Sequence:
MSGKPVLHYFNARGRMECIRWLLAAAGVEFEEKLIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIIQLVICPPDQREAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHLLELLLYVEEFDASLLTSFPLLKAFKSRISSLPNVKKFLQPGSQRKPAMDAKQIEEARKVFKF
Protein: Homeobox protein B-H2 (Homeobox protein BarH2) (Q24256)
Organism: Drosophila melanogaster (Fruit fly)
Function: B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein B-H1
- BG1
Sequence:
MTTMPPEMSATTAAPVGSAPSATAHHPAAVGGGMPRPASPAVGSNTTTATATTATRSRFMITDILAGAAAASAAAAAAAAALAAASSGGGRGSPTDSEREQSLVAQHHHHHQQQQQHHHHQQQQQQQQHQQAALQQYIVQQQQLLRFEREREREREREHYRERHSPPGNNPYAHHPMPPHLLAHFPPAHYAVLQQQQQQQQQQQHPHPHHLQLERERLEALHRHGHGLTGDPAQHLSHLSHLSHQQHHPHLHHPMHDERSRSPLMLQQLGGNGGNNNNNNNNSSSASNNNNNNNNSASANSNIISGNSSSSNNNNGSGNGNMLLGGPGSSISGDQASTIDDSDSDDCGGKDDDGDDSMKNGSSANGDSSSHLSLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRMELANKLELSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNYAAFQRLYGGATPYLSAWPYAAAAAAQSPHGATPSAIDIYYRQAAAAAAMQKPSLPASYRMYQSSIPPGMSLPGMPAPPPPGAAPMLSGYYAAAAAAAASAGAQQQQQQPPAASRSPATSQSANSEADCERTSSSSRQRLITPSPPLNPGSPPHRERINEEEDRERDEERDIERERERERERDEDDEEELALEV
Protein: Probable E3 ubiquitin-protein ligase LOG2 (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase LOG2) (Protein LOSS OF GDU2) (RING finger protein 215) (Q9S752)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (in vitro). Required for GLUTAMINE DUMPER 1(GDU1)-induced amino acid secretion and for amino acid homeostasis. Ubiquitinates GDU1 (in vitro).
Subcellular location: Cell membrane {ECO:0000269|PubMed:22291198}.
Interaction partners:
- Protein GLUTAMINE DUMPER 2
- Protein GLUTAMINE DUMPER 1
- Zinc finger CCCH domain-containing protein 34
- Protein DA1-related 2
- At5g05830
- Probable LRR receptor-like serine/threonine-protein kinase At4g31250
Sequence:
MGNISSSGGEGRRRRRRNHTAAPPPPPPPPSSSLPPPPLPTEIQANPIVFAAVTPYPNPNPNPVYQYPASYYHHPPPGAMPLPPYDHHLQHHPPHPYHNHSWAPVAMARYPYAGHMMAQPTPYVEHQKAVTIRNDVNLKKESLRLEPDPDNPGRFLVSFTFDATVSGRISVIFFAKESEDCKLTATKEDILPPITLDFEKGLGQKFKQSSGSGIDFSVFEDVELFKAAADTEIYPLAVKAEAAPSGGENEEEERSGSKNAQITQAVYEKDKGEIKIRVVKQILWVNGTRYELQEIYGIGNTVEGDDDSADDANDPGKECVICLSEPRDTTVLPCRHMCMCSGCAKVLRFQTNRCPICRQPVERLLEIKVHGNNGSGNNTGQGETVEQE
Protein: poly(A)-specific ribonuclease (EC 3.1.13.4) (E1JHY7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPSAISGAPHAHIPSNEECGIRDVWKQNLEEEFRTIRKVVQKYHYVAMDTEFPGVVARPVGEFRSTADYHYQLLRCNVDLLRIIQLGLTFMDDDGKTPPGYSTWQFNFKFNLSEDMYAQDSIDLLQNSGIQFKKHEEDGIDPIDFAELLMSSGIVLVENIKWLCFHSGYDFGYLLKLLTDQNLPPDESEFFDLLHIYFPNIFDIKYLMKSCKNLKGGLQEVADQLELRRVGPQHQAGSDALLTGMAFFKMREVQHTNDFHITPVAHDVLFRYLLEHTMNLKPTISCIHLLSRPAYNGGPAPDESAIISSGNGTGNTNSTEQFTSSAYMVTPPNTPGMAKSDAASLSNRHTSISNSFG
Protein: Rab-like protein 2A (E9Q9D5)
Organism: Mus musculus (Mouse)
Function: Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.
Interaction partners:
- Intraflagellar transport protein 22 homolog
- Intraflagellar transport protein 27 homolog
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 56
- Centrosomal protein of 19 kDa
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 25 homolog
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 46 homolog
Sequence:
MAGDRNRHCELEQEKYDTHENVKIICLGDSAVGKSKLMERFLMDGFQPQQLSTYALTLYKHTATVDGKTILVDFWDTAGQERFQSMHASYYHKAHACIMVFDVQRKITYKNLGTWYAELREFRPEIPCILVANKIDADIQMTQKNFSFAKKFSLPLYFVSAADGTNVVKLFNDAIRLAVAYKESSQDFMDEVLQELENFKLEQKEEDTSGQEQSDTTKSPSPS
Protein: Ribosomal protein S6 kinase (EC 2.7.11.1) (Q9PTN1)
Organism: Xenopus laevis (African clawed frog)
Interaction partners:
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase
- Uncharacterized protein.
- BZIP domain-containing protein.
- BZIP domain-containing protein.
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
- RAD50-interacting protein 1
- Vesicle transport protein USE1
- Hamartin isoform X3
Sequence:
MPLAQLADPWQKVPVQKVESENGQQFADESMCEEDNENNDEGNINEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVRKISGTDAGQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKYYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLTPEAQSLLRMLFKRNPTNRLGAGPDGVEEIKRHPFFVTIDWNKLFRREIQPPFKPATGGPEDTFYFDPEFTAKTPKDSPGIPASANAHQLFRGFSFVAISSEDENQAMQTVGVHAIVPLHRNSIQFTDGYELKEDIGVGSYSICKRCIHKGTNMEYAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYLVTELMKGGELLDKILRQKFFSEREASAVLHTITKTAEYLHSQWVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPEDTPEEILARIGSGKFSLSGGYWNSVSDIAKDLVSKMLHVDPHQRLTAAQVLKHPWIVHCDQLPQFQLNRQDAPHLVKGAMAATYSALNLNPMSPVLAPVGRSTLAQRRGVKKITSTAL
Protein: Mitochondrial Rho GTPase 1-A (MIRO-1-A) (EC 3.6.5.-) (Ras homolog gene family member T1-A) (Q6NVC5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Interaction partners:
- PTEN-induced kinase 1.
- E3 ubiquitin-protein ligase parkin
- Trafficking kinesin-binding protein 1 isoform X4
- Mitochondrial Rho GTPase 2
- Mitochondrial Rho GTPase
- Trafficking kinesin-binding protein 2 isoform X1
- Translocase of outer mitochondrial membrane 70 homolog A
- WD repeat-containing protein 90
- Mitochondrial import receptor subunit TOM20 homolog B
Sequence:
MRKDVRILLVGEPKVGKTSLIMSLVSEEFPDEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLYQEITKANVICIVYSVNNKKSIEKVTSHWIPLINERTDKDSRVPLILVGNKSDLVEHSSMETILPIMNQYSEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYSPEEKEMKPSCIKALTRIFKISDLDNDGILNDNELNFFQRTCFNIPLAPQALEDVKNVVRKNMTDGVKDNGLTLKGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLELTQEYLFPLFKIPPDCTTELNHNAYLFLQSVFDKHDKDRDCALSPDELKDLFKVFPYMPWGPDVNNTVCTNEQGWITYQGYLSQWTLTTYLDVQRCLEYLGYLGYSIIQEQESQAAAITVTRNKRIDLQKKQTQRSVFRCNVLGARGCGKSGFLQAFLGRNLVRQKRIREDHKSYYAISTTYVYGQEKYLLLHEVLPDVEFLSEADLACDVVCLVYDISNPRSFEYCAKVYKKHFMDSKTPCVIIAAKSDLHEARQYYSLSPLDFCRKHKLHPPQLFTCNTTEAPSKDLYTKLTTMAMYPHMTQADLKNSTFWLRASVGATVFAVLGFAMYKALLKQR
Protein: AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad) (O88512)
Organism: Mus musculus (Mouse)
Function: May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:O75843}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75843}; Cytoplasmic side {ECO:0000250|UniProtKB:O75843}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O75843}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75843}. Endosome membrane {ECO:0000250|UniProtKB:O75843}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75843}. Note=Mainly localized to perinuclear vesicular structures. Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments. Colocalizes with HBV major surface antigen L to cis-Golgi-like structures. {ECO:0000250|UniProtKB:O75843}.
Interaction partners:
- AP-1 complex subunit beta-1
- AP-1 complex subunit mu-2
- AP-1 complex subunit sigma-1A
- AP-1 complex subunit mu-1
- AP-1 complex subunit sigma-3
- AP-1 complex subunit sigma-2
- AP-1 complex subunit gamma-1
- AP-2 complex subunit beta
- AP-4 complex subunit mu-1
- AP-2 complex subunit mu
Sequence:
MVVHSLRLQDLIEEIRGAKTQAQEREVIQKECAQIRASFRDGDPLQRHRQLAKLLYVHMLGYPAHFGQMECLKLIASPRFTDKRVGYLGAMLLLDERHDSHLLITNSIKNDLSQGNQPVQGLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKDPELSGIFLPPCTKLLRERHHGIQLGTVTLITELCERNPAALRHFRKVVPQLVQILRTLVTTGYSTEHSISGVSDPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLLETVLTIMAIHSAAGLRVLAVNILGRFLLNNDKNIRYVALTSLLQLVQSDHSAVQRHRSTVVECLQETDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPSKRWHIDTILHVLTTAGAHVRDDAVANLTQLIGEAEELHTYSVRRLYSALAEDISQQPLVQVAAWCIGEYGDLLLEGNCEETEPFQVEEEDVLALLEKVLQSHMSLPATRGYAITALMKLSTRLRGDNNRIRQVVSIYGSCVDLELQQRAVEYNTLFQKYDHMRAAILEKMPLVERGDPHVKEGGKEKQTEAQPLEVTAPAPTEPQATKLLDLLDLLGDTSEPLSSGHAQHLPPQTPSPGEALIHLLDLPCTPPPPAPIPSVRVFEREGLQLDLSFMRPLETPALLLVTATTTNSSKEDVTHFVCQAAVPKSFQLQLQAPSGNTIPAQGGLPITQVFRILNPNQAPLRLKLRLTYNHSGQPVQEIFEVDNLPVETWQ
Protein: Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (EC 2.7.4.-) (P(i)-uptake stimulator) (PiUS) (Q80V72)
Organism: Mus musculus (Mouse)
Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) (By similarity). May play a role in the regulation of Na(+)-dependent phosphate cotransport, possibly via its role in diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) biosynthesis (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9UHH9}.
Interaction partners:
- Inositol-pentakisphosphate 2-kinase
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
- Inositol hexakisphosphate kinase 1
- Inositol hexakisphosphate kinase 3
Sequence:
MSPAFRTMDVEPRTKGILLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRRFTPQYKAVLIFVRCADEFGASGNIETKEQGVVSVRFEEDEDRNLCLIAYPLKGDHGTVDIVDNSDCEPKSKLLRWTNKKHHALETEKNPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYSVEKKGNVSSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGTGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKEWPEVTLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDSVVHEGQDAGYIFGLQSLIDIVTEISEESGE
Protein: Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1) (P23763)
Organism: Homo sapiens (Human)
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subcellular location: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein {ECO:0000269|PubMed:9658161}.
Interaction partners:
- Syntaxin-1A
- Synaptosomal-associated protein 25
- Synaptosomal-associated protein 23
- Syntaxin-1B
- Syntaxin-4
- Syntaxin-3
- Syntaxin-2
- Vesicle-associated membrane protein 2
- Complexin-3
- Syntaxin-6
Sequence:
MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVLERDQKLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVIYFFT
Protein: Mitoguardin 2 (Protein FAM73B) (Q7L4E1)
Organism: Homo sapiens (Human)
Function: Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:26711011}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Mitoguardin 1
- Vesicle-associated membrane protein-associated protein A
- Vesicle-associated membrane protein-associated protein B/C
Sequence:
MAFRRAEGTSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRRKKQVGPEMGGEQLGTVPLPILLARKVPSVKKGYSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSVASMMAVNSSSPTAACSGLWDARGMEESLTTSDGNAESLYMQGMELFEEALQKWEQALSVGQRGDSGSTPMPRDGLRNPETASEPLSEPESQRKEFAEKLESLLHRAYHLQEEFGSTFPADSMLLDLERTLMLPLTEGSLRLRADDEDSLTSEDSFFSATELFESLQTGDYPIPLSRPAAAYEEALQLVKEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEDKSNQLFFGKVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGRGVVCMSFFDIVLDFILMDAFEDLENPPASVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLAEVCAFFKHQIVQYLRDMFDLDNVRYTSLPALADDILQLSRRRSEILLGYLGVPAASSAGVNGALPRENGPLGELQ
Protein: MYB transcription factor (Myb domain protein 116) (Myb family transcription factor) (Putative transcription factor MYB116) (Q94FU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSNITKKKCNGNEEGAEQRKGPWTLEEDTLLTNYISHNGEGRWNLLAKSSGLKRAGKSCRLRWLNYLKPDIKRGNLTPQEQLLILELHSKWGNRWSKISKYLPGRTDNDIKNYWRTRVQKQARQLNIDSNSHKFIEVVRSFWFPRLINEIKDNSYTNNIKANAPDLLGPILRDSKDLGFNNMDCSTSMSEDLKKTSQFMDFSDLETTMSLEGSRGGSSQCVSEVYSSFPCLEEEYMVAVMGSSDISALHDCHVADSKYEDDVTQDLMWNMDDIWQFNEYAHFN