wanglab/gogpt-training-data huggingface dataset:
Protein: Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1) (P41831)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ribose-phosphate pyrophosphokinase 5
- Ribose-phosphate pyrophosphokinase 2
- Probable transketolase
- Amidophosphoribosyltransferase
- Ribose-5-phosphate isomerase
- Ribokinase
- Probable phosphoribomutase
- Phosphoglucomutase
- Uncharacterized Nudix hydrolase P35G2.12
- ATP phosphoribosyltransferase
Sequence:
MKSATIIGGGSHPELLHLISNRLGITPCDVSLKRFANGETSVEIRESVRDKDVFILQSGSSTVNDSLMELLIIISACKGGSAKRITAVMPYFPYSKQSKMRKYRDAITARMVANLLTVAGVDHIITLDLHASQMQGFFTRPVDNLYAEPNIAEWIRRNVDDWEEAVVVSKNPGGAKRVTSLADTLNLDFALINTDRQRSSHFSQNFEDSIMDETEATETHVTNCSVYLDRPRIHTAKYLLGHIIDDEEIITTPASVCSEDYAQEVNLYSQGGCPSDDDEEENIMSASIYAERMITLVGDVNGKTALLIDDTIENPTAFIVASEHLVKRCGAKRVIVIGTHGIFQNKCLKDLQSCEYIEQIVVTNTYPIKPQAVLECDKLTVIDISGVLAEAIRRTHNGESISFLFKKAF
Protein: Protein kinase OspG (EC 2.7.-.-) (Effector protein OspG) (Q99PZ6)
Organism: Shigella flexneri
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is a kinase that is involved in down-regulation of the host innate response induced by invasive bacteria. Prevents or at least delays host phospho-NF-kappa-B inhibitor alpha (NFKBIA) degradation. Does not phosphorylate E2 enzymes.
Subcellular location: Secreted {ECO:0000269|PubMed:11115111}. Host cell {ECO:0000305|PubMed:11115111}. Note=Secreted via Mxi-Spa type III secretion system (T3SS), and delivered into the host cell. {ECO:0000305}.
Interaction partners:
Sequence:
MKITSTIIQTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEMAWQESELFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGNMLYDKESESLFPIDFRNIYAEYYAATKKDKEIIDRRLQMRTNDFYSLLNRKYL
Protein: Zinc finger protein 345 (Zinc finger protein HZF10) (Q14585)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MENLTKHSIECSSFRGDWECKNQFERKQGSQEGHFSEMIFTPEDMPTFSIQHQRIHTDEKLLECKECGKDFSFVSVLVRHQRIHTGEKPYECKECGKAFGSGANLAYHQRIHTGEKPFECKECGKAFGSGSNLTHHQRIHTGEKPYECKECGKAFSFGSGLIRHQIIHSGEKPYECKECGKSFSFESALIRHHRIHTGEKPYECIDCGKAFGSGSNLTQHRRIHTGEKPYECKACGMAFSSGSALTRHQRIHTGEKPYICNECGKAFSFGSALTRHQRIHTGEKPYVCKECGKAFNSGSDLTQHQRIHTGEKPYECKECEKAFRSGSKLIQHQRMHTGEKPYECKECGKTFSSGSDLTQHHRIHTGEKPYECKECGKAFGSGSKLIQHQLIHTGERPYECKECGKSFSSGSALNRHQRIHTGEKPYECKECGKAFYSGSSLTQHQRIHTGEKLYECKNCGKAYGRDSEFQQHKKSHNGKKLCELETIN
Protein: Transcription termination factor nun (P18683)
Organism: Escherichia phage HK022 (Bacteriophage HK022)
Interaction partners:
Sequence:
MLMVKKTIYVNPDSGQNRKVSDRGLTSRDRRRIARWEKRIAYALKNGVTPGFNAIDDGPEYKINEDPMDKVDKALATPFPRDVEKIEDEKYEDVMHRVVNHAHQRNPNKKWS
Protein: FLYWCH transcription factor 2 (Q18225)
Organism: Caenorhabditis elegans
Function: Probable transcription factor. May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-1 and flh-3.
Interaction partners:
- FLYWCH-type domain-containing protein.
Sequence:
MVDTMMNTNTDGVTAVPPIFPLPSTTPNRNNNNELAMLAQKQIVAGLLLQQPTIVQAAVNGTNSQKHLADIDYTNVIQTLQALGTTNLKAFSLLLDPQSQTSQLISEDTRPSASSSPSSTATAVSNSGQSNATSTSSSSTEPEYKPRNVREKVYADGYIMSFDKKSCCGTKEFWRCERKNDCNARMHSDINTREIVRKLHPHNHEKPSPEELAFYEQDFSTLHPNYCHPVKSINRSYMQRKLSRASHVSQALPIAPQQIKAEPMEVDTTNQTIQNFQQNNNLMLLASINAAATAAAAATSAGISPPVVGQKRVSTTVMPITLKSQRTTPKEEEDSSQLMSQEEFRITYELTKKLMEMMKPKTEIGVRWQGDEGSILLFLSHDNGAEENVFFPVVVMNRDEKSLITALEGFTGKRCEGKLALCYSQRVNVLVHEALISNWTHGKLFLVNTDAPALWRLTPVDAFGEPLNHV
Protein: Fatty acyl-CoA reductase 2 (FAR2) (EC 1.2.1.84) (Male sterility domain-containing protein 1) (Q96K12)
Organism: Homo sapiens (Human)
Function: Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity).
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:15220348, ECO:0000269|PubMed:24108123}; Single-pass membrane protein {ECO:0000305|PubMed:24108123}.
Interaction partners:
- Fatty acyl-CoA reductase 1
- Dihydroxyacetone phosphate acyltransferase
- Alkyldihydroxyacetonephosphate synthase, peroxisomal
- Fatty acid synthase
Sequence:
MSTIAAFYGGKSILITGATGFLGKVLMEKLFRTSPDLKVIYILVRPKAGQTLQQRVFQILDSKLFEKVKEVCPNVHEKIRAIYADLNQNDFAISKEDMQELLSCTNIIFHCAATVRFDDTLRHAVQLNVTATRQLLLMASQMPKLEAFIHISTAYSNCNLKHIDEVIYPCPVEPKKIIDSLEWLDDAIIDEITPKLIRDWPNIYTYTKALGEMVVQQESRNLNIAIIRPSIVGATWQEPFPGWVDNINGPNGIIIATGKGFLRAIKATPMAVADVIPVDTVVNLMLAVGWYTAVHRPKSTLVYHITSGNMNPCNWHKMGVQVLATFEKIPFERPFRRPNANFTSNSFTSQYWNAVSHRAPAIIYDCYLRLTGRKPRMTKLMNRLLRTVSMLEYFINRSWEWSTYNTEMLMSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDMAGIPKAKQRLKRLRNIHYLFNTALFLIAWRLLIARSQMARNVWFFIVSFCYKFLSYFRASSTLKV
Protein: Antirepressor for MexR, ArmR (Q9HXS2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Multidrug resistance operon repressor
- Uncharacterized protein
- NalC
- NalD
- Outer membrane protein OprM
- Secreted protein
- Rhodanese domain-containing protein
- Multidrug resistance protein MexA
Sequence:
MSLNTPRNKPSRTETEAVAASSGRSAVGRRDYTEQLRRAARRNAWDLYGEHFY
Protein: Mitochondrial carrier protein, putative (Q57VA8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
- Peroxin 19
- Peroxisome assembly protein, putative
- Peroxin-13
Sequence:
MALPTSHVVQTPKRQEYLASCLSGCVAGVCSTCVINPLDTVRVRLSVSRSATGKAHRSLLYTVRDLFEGGIVHAFSRGLSANLMASLPSNGIYLPTYRCIKDQLSSAGVNQNVQPAIAACGAVCVTNTILGPIFLVRTRVQVNEKLTVRQTFRDVLKHEGFSGFYRGTMTNIVGRFVEEGLFWSIYELLKRLSNEASFKGSSNFFLTSVAVASLSAVAKIAATTVSYPYNVVMNHMRSVSYVTGKPEYERIMPTIRHIYYQDGIPGFYKGLAPQLLRSTLSKAVQIYSFELAMFIYFSTVQRPVVSCAPA
Protein: Kojibiose phosphorylase (EC 2.4.1.230) (P77154)
Organism: Escherichia coli (strain K12)
Function: In vitro catalyzes the phosphorolysis of D-kojibiose into beta-D-glucose 1-phosphate and D-glucose. No other disaccharides tested substitute for D-kojibiose. In the reverse direction disaccharides can be formed from beta-D-glucose 1-phosphate plus D-glucose, L-sorbose, D-sorbitol, L-iditol or 1,5-anhydro-D-glucitol, but with low efficiency. The beta-D-glucose 1-phosphate product is the substrate for YcjU (AC P77366), the next apparent enzyme in the putative biochemical pathway encoded in this locus (yjcM to ycjW).
Interaction partners:
- Beta-phosphoglucomutase
- Putative ABC transporter periplasmic-binding protein YcjN
- 3-dehydro-D-guloside 4-epimerase
- D-guloside 3-dehydrogenase
- D-glucoside 3-dehydrogenase
- Inner membrane ABC transporter permease protein YcjO
- Glucosylglycerate phosphorylase
- Inner membrane ABC transporter permease protein YcjP
- Uncharacterized HTH-type transcriptional regulator YcjW
- Outer membrane porin G
Sequence:
MTRPVTLSEPHFSQHTLNKYASLMAQGNGYLGLRASHEEDYTRQTRGMYLAGLYHRAGKGEINELVNLPDVVGMEIAINGEVFSLSHEAWQRELDFASGELRRNVVWRTSNGSGYTIASRRFVSADQLPLIALEITITPLDADASVLISTGIDATQTNHGRQHLDETQVRVFGQHLMQGSYTTQDGRSDVAISCCCKVSGDVQQCYTAKERRLLQHTSAQLHAGETMTLQKLVWIDWRDDRQAALDEWGSASLRQLEMCAQQSYDQLLAASTENWRQWWQKRRITVNGGEAHDQQALDYALYHLRIMTPAHDERSSIAAKGLTGEGYKGHVFWDTEVFLLPFHLFSDPTVARSLLRYRWHNLPGAQEKARRNGWQGALFPWESARSGEEETPEFAAINIRTGLRQKVASAQAEHHLVADIAWAVIQYWQTTGDESFIAHEGMALLLETAKFWISRAVRVNDRLEIHDVIGPDEYTEHVNNNAYTSYMARYNVQQALNIARQFGCSDDAFIHRAEMFLKELWMPEIQPDGVLPQDDSFMAKPAINLAKYKAAAGKQTILLDYSRAEVNEMQILKQADVVMLNYMLPEQFSAASCLANLQFYEPRTIHDSSLSKAIHGIVAARCGLLTQSYQFWREGTEIDLGADPHSCDDGIHAAATGAIWLGAIQGFAGVSVRDGELHLNPALPEQWQQLSFPLFWQGCELQVTLDAQRIAIRTSAPVSLRLNGQLITVAEESVFCLGDFILPFNGTATKHQEDE
Protein: DNA glycosylase superfamily protein (F4HXH4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At3g50880
- At1g19480
- Endonuclease III homolog 2, chloroplastic
- Endonuclease III homolog 1, chloroplastic
- At1g15970
- DNA glycosylase superfamily protein
- At1g80850
- DNA glycosylase superfamily protein
- High mobility group B protein 5
Sequence:
MGEHSPSQPSSHTLPPNQPESPNHETPNPIPPETNDDDSASSAGVSGSIVSSTTIEAPQVTELGNVSSPPTKIPLRPRKIRKLSPDDDASDGFNPEHNLSQMTTTKPATKSKLSQSRTVTVPRIQARSLTCEGELEAALHHLRSVDPLLASLIDIHPPPTFETFQTPFLALIRSILYQQLAAKAGNSIYTRFVALCGGENGVVPENVLPLTPQQLRQIGVSGRKASYLHDLARKYQNGILSDSGIVNMDEKSLFTMLTMVNGIGSWSVHMFMINSLHRPDVLPVNDLGVRKGVQMLNGMEDLPRPSKMEQLCEKWRPYRSVASWYLWRLIESKNTPPNAAAATAGAALSFPQLEDIQQQEQEQQHQQHQQQQPQLMDPLNNVFSIGYSQLHCAT
Protein: Nexilin (F-actin-binding protein) (Q7TPW1)
Organism: Mus musculus (Mouse)
Function: Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q0ZGT2, ECO:0000250|UniProtKB:Q9Z2J4}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q0ZGT2, ECO:0000250|UniProtKB:Q9Z2J4}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9Z2J4}. Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ. {ECO:0000250|UniProtKB:Q0ZGT2, ECO:0000250|UniProtKB:Q9Z2J4}.
Interaction partners:
- Drebrin
- Hematopoietic lineage cell-specific protein
- Src substrate cortactin
Sequence:
MNDVSQKAEIKEMLASDDEEESSPKIEKAYVPKLTGTVKGKFDEMEKHRQEEQRKRTEEERKRRIEQDLLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPAKSYKTPGKTKDPEDLDREEGNGRTNHEEDKMRYEEECRVLKEAKCLSLVMDDETEAKKESHFPGKLKSTFEELERQRQENRKKQAEEEARRRLEEERRSFEEARRHMVNEEDENQDRETVFKEYRPGKLKLSFEEIERQRREDEKRKAEEEARRRIEEEKAAFAEARRSMVLDDDSPEIYKTVSQESLTPGKLEINFEQLLRQKMEEERRRTEEERRHKLEMEKQEFEQLRQEMGKEEEENESFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEVQKKIEEERAKRRAIDLEIKEREAENFHEDDDVDVRPAKKSESPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQKEIDAALQKKREDEEEEEGSIVNGSTTEDEEQTRSGAPWFKKPLRNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIEMDDY
Protein: Syntaxin (Q9GU66)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Interaction partners:
Sequence:
LQPPAEGKSGNGYLFEDDEQAIDDHFQRPPASRMTQQQLLLFEEENTRVAQHREQEVTKIVKSIYDLNDIFKDLGHMVQEQGTVLDRIDYNVEQTQTRVSEGLRQLHKAEMYQRKNRKMCVILVLAAVTFFMLLLLILTKL
Protein: F-box/kelch-repeat protein At5g39560 (Q6NL02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein SCAR4
- Expressed protein
- Methionine aminopeptidase 1C, chloroplastic/mitochondrial
- acid phosphatase
- Photosystem I assembly factor PSA3, chloroplastic
- Plasma membrane fusion protein
Sequence:
MLLPFPATMISEVEQPKEKRSLSSEPPSLMSLPYEIIENILARISKWSYPNLSLVSKSFLSLLSSPQLYKTRSEIGTTEPCLYFCLESANHSSPQWYTLWMKPDETLTGTGTIHDYSLIPLPSSSPVLRTSTVAVGSEIYVIGGHFNRSSSVRIFDCRSNTWRDGPNMTVARSDPVAVLIDQRIYVLGGREMDESDDWFEVFDIKTQTWRALPSFRAGLELRRYIVWPNRYFPRLGDSQTAVRLINVNPNALEGKLYVAAQINDYTYEPKDDTWKVVSKSSIRRVKVWCVIENVMYACHDVFLRWYDYEDRRWREIQGLEELCYHPTRGFSGAERIVNYGGKLVVMWRPVQSDGKDKIEIWCAQIALEKRSKDEIWGKIEWINSVLTVPKLCDLCYSCVVVSI
Protein: GTP-binding protein 1 (D2XV59)
Organism: Rattus norvegicus (Rat)
Function: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21515746}.
Interaction partners:
- Pancreatic secretory granule membrane major glycoprotein GP2
- Exosome complex component RRP4
- NPC intracellular cholesterol transporter 1
- Exosome complex exonuclease RRP44
- Exosome complex component 10
- DIS3-like exonuclease 1
- Exosome complex component RRP41
- Dystroglycan 1
- Exosome complex component CSL4
- Exosome complex component RRP45
Sequence:
MAAERSRSPVDSPVPASMFAPEPSSPGAARAAAAAARLHGGFDSDCSEDGEALNGEPELDLTSKLVLVSPTSEQYDSLLRQMWERMDEGCGETIYVIGQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQESGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSSKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLSKREEGGPSGVPAAGPPSTGDEASSLGTTQAATSSGLQPQPKPSSGGRRRGGQRHKVKSQGACVTPASGC
Protein: NADH-quinone oxidoreductase subunit A (EC 7.1.1.-) (NADH dehydrogenase I subunit A) (NDH-1 subunit A) (NUO1) (Q5F615)
Organism: Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Subcellular location: Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01394}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01394}. Cell membrane {ECO:0000256|RuleBase:RU003639}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003639}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- NADH-quinone oxidoreductase subunit B
- NADH-quinone oxidoreductase subunit J
- NADH-quinone oxidoreductase subunit F
- NADH-quinone oxidoreductase subunit H
- NADH-quinone oxidoreductase subunit D
- NADH-quinone oxidoreductase subunit K
- NADH dehydrogenase
- NADH:ubiquinone oxidoreductase subunit L
- NADH-quinone oxidoreductase subunit C
- NADH:ubiquinone oxidoreductase subunit M
Sequence:
MLSAYFPVFVFILVGLAAGVLFILLGTILGPKRHYAEKDAPYKCGFESFENARMKFDVRYYLVDILFILFDLEVAFMLPWAVVFKDLGAYGFWSMLVFIVVLTVGFVYEWKKGALEWE
Protein: U1 small nuclear ribonucleoprotein 70 kDa homolog (U1 70K) (U1 snRNP 70 kDa homolog) (U1-70K) (U1 small nuclear ribonucleoprotein usp101) (U1 snRNP protein usp101) (O13829)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in nuclear mRNA splicing (By similarity). Essential for growth.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- U1 snRNP-associated protein usp107
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D1
- U1 snRNP-associated protein usp106
- Small nuclear ribonucleoprotein-associated protein B
- Pre-mRNA-processing factor 39
- Small nuclear ribonucleoprotein F
Sequence:
MAEKLPAPLLALFAPRPPLRYLPPMDVPPEKRSTPRVSGIAKYLKYAQSHDQQYHPTESLEEKRLRLRDEKQKQQRERLRSMIKVWDPDHDRHVIGDPYKTMFLSRLSYDTKESDIEREFTRYGPIERIRVVRNKVTGKSMGYAFVVFERERDLKVAYKASAGLMLNGRRIVVDVERGRTVKGWLPRKLGGGLGGRHYTKERPRRERGSRFRGDSGFRGGYRGGFRKSSGGGSRFGRGPTRSSHSSDYGGRDSSPKRRRYN
Protein: Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) (RalGDS-related effector protein of M-Ras) (Ras pathway modulator) (RPM) (Q3UYI5)
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1.
Interaction partners:
- GTPase KRas
- GTPase HRas
- Ras-related protein Ral-B
- Ras-related protein Ral-A
Sequence:
MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRSTPERSGEGQTPIPATDTFLHYRTSKVRALRAARLERLVHELVSGDREQDPGFVPAFLATHRAFVPTARVLGFLLPPPPPPPPPPAGVDSKRTEGQDLNFSKNLRAVVSVLGSWLRNHPQDFRDPPDHQNLGNVRIFLGWAAPGGAEAREAEKLLEDFLKEAKGEQTEEEKRLAWSGPPRIAQTPGSEFAEDCVEEEGPSSEGPELLDFSVDDVAEQLTLMDVELFLRVRSCECLGSMWSQRDRPGAAGISPTVRATVAQFNTVTGCVLGSVLAAPGLAASQRAQRIEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSVFRKLSQIFSDEDNHLSSRAILSQEETTEDDDCPSGSLPSKLPPGPVPYLGTFLTDLVMLDTALPDTLKGNLINFEKRRKEWEILARIQQLQQRCQRYSLSPRPPILAALRAQRQLSEEQSYRVSRVIEPPAASCPSSPRIRRRISLTKRLSAKLSREKNSSPGGSPGDPSSPTSSVSPGSPPSSPRNREPPPPGSPPASPGPQSPSTKLSLTMDPPGPWPVTLTPSSSRVPLLGQQTSEARVIRVSINNNHGNLYRSILLTCQDKAPSVVQRALEKHNVPQPWARDYQLFQVLPGDRELLIPDGANVFYAMSPAAPGDFLLRRKEGTGHTLSASPT
Protein: Hexosyltransferase (EC 2.4.1.-) (Q57YS2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU363063}.
Interaction partners:
Sequence:
MTQRKVYPPYSWRKPRASVLVLTTTFTMALIIIMWDIYHISEVHSNSSYDLLGTFENDYYLTLTPPSTVSIWQEREFLVIVGIPSVDRDEWQKRRNLQRRTCWQYAGVATLENNFTGELLPLYLLAPHQLNGYEISESLRDEASRTNDVVMLPTNDVCSLARRKIGEGGSWGVESELVMSRKTFLWLQFAVTAFPNVSYIVKGDDDVFVRVPQYLADLRVMPRNGLYMGRVYGATFFWRSGGIPFAAGYFTTFSRDVAEAVASYRPLERLLKAPYSIWRMRQYLSMSVLHEDVMSALVLQDKIRYKGLIIANAAGCHFHNKAKEDIREAVSNRSVVVHHIREEDYEVLMDHFSNISERPQPYGVRWLRNDRAMVLC
Protein: Protein kinase superfamily protein (F4HQ88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MTDQSSVDGILEFLRNNRFSQAEEALRNELNNRSDINGFLQKLKLEDKDSNEKAAGNELRRSGSRDSEVSKELIVKEVDCGTSTNGSVIKWENGATADNPSKKEPVVSSEMSFTFSKNSGDAAAPPDAHSYKFTSRNGTVEPSRNIDDSSSSSLVDLYAFEQSRHGNFADIDKKIVETGEDIVFFGNKSTSWSGNSSKGNSGSKIKEPNEIHRLVENSGKHDSYKGSILLRSEDVVDTSANWRECSVKTLFQSSRGDASNSYNLVSSSDKREGKKKADISDVRVAIKEQESEVARALFFGKSQSTFDDKNISSLGFPLVYDTRKEEFPRLPPVKLKSEDNPLSLHCEEKFERDGSGPRLINDEDALLIGSYLDVPIGQEISSSGGKKSTGGNWLSVSQGIAEDASDLVSGFATIGDGLSESVDYRNEYWDSDEYEDDDDIGYVRQPIEDEPWFLAHEIDYPSDHEKGTTRGSPDHHERDANKDADDQSYAEEASYISGEQYLQSKDAEPISSENDRRLTVSEIYPASKKNDLLAQYDGHLMDEELLSSMRDEPVWQGFVAQSNELLMLGDKKGINVHRKSHRDDVYVEDDQHDSVRSIGVGINSDAADFGSEVRDSLAGGSSEGDFEYSRDHDPVASRFKQLYSESDKKHIDAPNKNKQQASKNDGPDYIADNDSSGSFHVKIQTDGGFSFGSSQKDGQSMHAESSKSLWSGNHETVTRDRNTERLSASTAMDDMVATWRRKSSDSSSSHSSVKDNNATSIKSLNSSPSSLSNYACEERKHADKEDDRNDSSEIEDDNATALDDEEAVAVQEQVRQIKAQEEEFETFDLKIVHRKNRTGFEEEKNFNVVLNSVIAGRYHVTEYLGSAAFSKAIQAHDLQTGMDVCIKIIKNNKDFFDQSLDEIKLLKYVNKHDPADKYHLLRLYDYFYYREHLLIVCELLKANLYEFHKFNRESGGEVYFTMPRLQSITIQCLESLQFLHGLGLIHCDLKPENILVKSYSRCEIKVIDLGSSCFETDHLCSYVQSRSYRAPEVILGLPYDKKIDVWSLGCILAELCTGNVLFQNDSPASLLARVMGIVGSFDNEMLTKGRDSHKYFTKNRMLYERNQESNRLEYLIPKRTSLRHRLPMGDQGFTDFVAHLLEINPKKRPSAAEALKHPWLSYPYEPISA
Protein: Leucine-rich repeat-containing protein 52 (BK channel auxiliary gamma subunit LRRC52) (Q5M8M9)
Organism: Mus musculus (Mouse)
Function: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity). KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties, shifting KCNU1 gating to more negative potentials at a given pH.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22084117}; Single-pass membrane protein {ECO:0000269|PubMed:22084117}. Note=Expression at the cell surface may require the presence of KCNU1.
Interaction partners:
- Potassium channel subfamily U member 1 current)
- Calcium-activated potassium channel subunit beta-1
- Calcium-activated potassium channel subunit alpha-1
Sequence:
MSLASGPSSKLLLFSLGMGLVSGSKCPNKCVCQDQEVACIDLHLTEYPADIPLNTRRLYLNNNKITSLPALQLGFLSDLVYLDCQNNRIREVMDYTFIGIFRLIYLDLSSNNLTSISPFSFSVLTNLVRLNISHNPHLLYLDKYVFANTTSLRYLDLRNTGLHIIDHNGFHHLVVLQTLYLSGNPWICNCSFLDFTIHLLVSHMDHPDAQNATCTEPAELKGWPITKVGNPLQYMCITHLDQQDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNALRTSSGDDTEDETGSRFANQIFRSNTHLGPIRRFPELI
Protein: Sarcosine oxidase, alpha subunit (Q5JFD7)
Organism: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Interaction partners:
- Sarcosine oxidase, beta subunit
- Proline dehydrogenase, beta subunit
- Proline dehydrogenase, alpha subunit
- Serine hydroxymethyltransferase
- Probable glycine dehydrogenase
- Probable glycine dehydrogenase
- 2-amino-3-oxobutyrate coenzyme A ligase
- Proline dehydrogenase, gamma subunit
Sequence:
MRPLDLTEKDPSKKITIYLDGEPYEAYEGEKFPVAMLANGVYWLTTSNEGRHRGAFTFGPVPVTVNGVKNINGRKLKLKDGMKIERQRYDEFQEQVEIDEGKPVLRYVVDVAVIGAGPAGLGVVEEIGGKLTVALIEEKGWLGGDMWLKGVEQEGFGNPREAIERLTNFPENVRVFLKTAALGVYDKGEYFLVPAVRNDQLIEFMAKKVVLATGAVDNIMLFENNDWPGVFRRADALEVMNVWGVAPGRKVAVTGAFPEEITAELERWGIEYIIVPNVKRVEGEDRIERVIDENGNVYEVDALIMADGRIPDINPITQAGGKLRFKRGYYMPILDDEHRIRDGIYVAGSAVSIKPHYANYLEGKLVGAYILREFGYESEPCIYEERLKEYEPVARPVPKLPLDNFNGEDVQICGCGVTLKKVDDVVRSGITDLQIIKRLTHLAMGFCQGRFCLFNGALLVSQRSGMGMDRLDIPVARPPIKNVKMKVVAGRD
Protein: DNA gyrase subunit A (EC 5.6.2.2) (Type IIA topoisomerase subunit GyrA) (P9WG47)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state, while in the absence of ATP it relaxes supercoiled dsDNA. Also catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Gyrase from M.tuberculosis has higher decatenation than supercoiling activity compared to E.coli; as M.tuberculosis only has 1 type II topoisomerase, gyrase has to fulfill the decatenation function of topoisomerase IV as well. At comparable concentrations M.tuberculosis gyrase cannot introduce as many negative supercoils into DNA as the E.coli enzyme, and its ATPase activity is lower, perhaps because it does not couple DNA wrapping and ATP binding as well as E.coli.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01897}.
Interaction partners:
- DNA gyrase subunit B
- DNA-directed RNA polymerase subunit beta
- Enoyl-[acyl-carrier-protein] reductase
- Nicotinamidase/pyrazinamidase
- Probable arabinosyltransferase B
- Small ribosomal subunit protein uS12
- DNA-directed RNA polymerase subunit beta'
- 16S/23S rRNA
- Uncharacterized protein Rv0007
- DNA-directed RNA polymerase subunit alpha
Sequence:
MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSAGDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN
Protein: Curli production assembly/transport component CsgE (P0AE95)
Organism: Escherichia coli (strain K12)
Function: May be involved in the biogenesis of curli organelles.
Interaction partners:
- CsgBAC operon transcriptional regulatory protein
- Curli production assembly/transport component CsgG
- Curli production assembly/transport component CsgF
- Major curlin subunit
- Minor curlin subunit
- Curli assembly protein CsgC
Sequence:
MKRYLRWIVAAEFLFAAGNLHAVEVEVPGLLTDHTVSSIGHDFYRAFSDKWESDYTGNLTINERPSARWGSWITITVNQDVIFQTFLFPLKRDFEKTVVFALIQTEEALNRRQINQALLSTGDLAHDEF