wanglab/gogpt-training-data huggingface dataset:
Protein: Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Q8CI85)
Organism: Mus musculus (Mouse)
Function: Reversible hydration of carbon dioxide.
Subcellular location: Membrane {ECO:0000250|UniProtKB:O43570}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O43570}. Cell membrane {ECO:0000250|UniProtKB:O43570}.
Interaction partners:
Sequence:
MPHRSLRATVVLLLVILKKQPSSSAPLNGSKWTYVGPAGEKNWSKKYPSCGGLLQSPIDLHSDILQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNSDMYIQGLQPHHYRAEQLHLHWGNRNDPHGSEHTVSGKHFAAELHIVHYNSDLYPDFSTASDKSEGLAVLAVLIEIGSANPSYDKIFSHLQHVKYKGQQVLIPGFNIEELLPESPGEYYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDPTPREMINNFRQVQKFDERLVYISFRQGLLTDTGLSLGIILSVALAGVLGISIVLAVSIWLFKRKKSKKGDNKGVIYKPAIKKEAEVHA
Protein: Epididymis secretory sperm binding protein (Histidine triad nucleotide binding protein 1) (A0A384NPU2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
Protein: At5g53080 (Tetratricopeptide repeat (TPR)-like superfamily protein) (Q5XEY4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Tetratricopeptide repeat domain-containing protein PYG7, chloroplastic
- Guanylate kinase 3, chloroplastic
Sequence:
MVFSNSLLSSTTSLTTWANQSSSQSSLSPRYSTWQCVCLRNQKRKPKLYLIPARHFLSTPIDSVSSSSITASRYATSGVSEVQRSTSSNNVTEMEEFEMELQELFNEVKSMVKIGKESDAMDLLRANYVAVKEELDSGLKGIEQAAVLDIIALGYMAVGDLKPVPALLDMINKIVDNLKDSEPLLDSVLMHVGSMYSVIGKFENAILVHQRAIRILENRYGKCNTLLVTPLLGMAKSFASDGKATKAIGVYERTLTILERNRGSESEDLVVPLFSLGKLLLKEGKAAEAEIPFTSIVNIYKKIYGERDGRVGMAMCSLANAKCSKGDANEAVDIYRNALRIIKDSNYMTIDNSILENMRIDLAELLHFVGRGDEGRELLEECLLINERFKGKNHPSMATHLINLAASYSRSKNYVEAERLLRTCLNIMEVSVGSEGQSITFPMLNLAVTLSQLNRDEEAEQIALKVLRIREKAFGEDSLPVGEALDCLVSIQARLGRDDGEILGLLKRVMMIQEKEFGPSAQELIVTLQKIIHFLEKLEMKDDKFKFRRRLALLRERYKQSLSY
Protein: Aragonite protein AP24 (Q9BP38)
Organism: Haliotis rufescens (California red abalone)
Interaction partners:
Sequence:
MTWMKMFYLTLAVTAAVLLVTVAAADDDEDASSGLCNQYNQNVTTRPNNKPKMFLRKNINFEIISVHNIWRDPNTVYWCDFSLEEEDGIKHWRHYDFNATHWWVEKGCSGTFVVEECNTKDITNPGPRSTAGKSPMQGTLAAPKPVANWMSIMSRSRFDMGTWDKEGFNML
Protein: Lysophosphatidylserine lipase ABHD12 (EC 3.1.1.-) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (Monoacylglycerol lipase ABHD12) (EC 3.1.1.23) (Oxidized phosphatidylserine lipase ABHD12) (EC 3.1.-.-) (Q99LR1)
Organism: Mus musculus (Mouse)
Function: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30237167}; Single-pass membrane protein {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:20657592}.
Interaction partners:
- Monoacylglycerol lipase ABHD6
- Disks large homolog 4
- Voltage-dependent calcium channel gamma-4 subunit
- Glutamate receptor 1
- Palmitoyl thioesterase CPT1C
- Glutamate receptor 2
- Noelin
- Protein shisa-9
- Epidermal growth factor receptor kinase substrate 8
- Glutamate receptor 4
Sequence:
MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHAIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPERQH
Protein: Exportin-T (Exportin(tRNA)) (Protein PAUSED) (tRNA exportin) (Q7PC79)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable tRNA nucleus export receptor which regulates tRNA processing and facilitates tRNA translocation across the nuclear pore complex. Is required for proper activity of the shoot apical meristem (SAM) and correct leaf initiation at different developmental stages, and may play a role in floral patterning.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
Interaction partners:
- GTP-binding nuclear protein Ran-2
- GTP-binding nuclear protein Ran-3
- GTP-binding nuclear protein Ran-4
- GTP-binding nuclear protein Ran-1
- Methionine--tRNA ligase, cytoplasmic
- Protein HASTY 1
- At2g40570
- Protein EXPORTIN 1B
- Nuclear cap-binding protein subunit 1
- tRNA-splicing endonuclease subunit Sen2-2
Sequence:
MDDLEQAIVISFETGAVDSALKSQAVTYCQQIKETPSICSICIEKLWFSKLVQVQFWCLQTLQDVLRVKYGSMSLDEQSYVRKSVFSMACLEVIDNENAGRVVEGPPFVKNKLAQVLATLIYYEYPLIWSSVFLDFMLHLCKGAVVIDMFCRVLNALDDELISLDYPRTPEEISVAARVKDAMRQQCVPQIARAWYDIVSMYKNSDPDLSATVLDCMRRFVSWIDIGLVANDAFVPLLFELILSDGLSEQVRGAAAGCVLAMVSKRMDPQSKLPLLQTLQISRVFGLVSGDVDSDLVSKVSALLTGYAVEVLECHKRLNSEDTKAVSMDLLNEVLPSVFYVMQKCEVDSTFSIVQFLLGYVSTLKGLPALKEKQLLHITQILEVIRIQICYDPMYRNNLNSLDKTGLEEEDRMSEFRKDLFVLLRTVGRVAPEVTQHFIRNSLANAVESSSESNVEEVEAALSLLYSFGESMTEEAMKTGSGCLSELIPMLLTTQFPGHSHRLVALVYLENITRYMKFIQENSQYIPNVLGAFLDDRGLHHQNFYVSRRAGYLFMRVVKLLKSKLVPFIDKILQNLQDTLSQLTTMNFASRELTGTEDGSHIFEAIGIIIGLEDVPAEKQSDYLSLLLTPLCQQIEAGLVQAKVASSEDFPVKIANIQFAIVAINALSKGFNERLVTASRPGIGLMFKQTLDVLLRVLIEFPKVEPLRSKVTSFIHRMVDTLGSAVFPYLPKALEQLLADSEPKEMVGFMVLLNQLICKFNSALHDILEEVYPVVAVRIFNVIPRDGLPSRPGAVTEEMRELIELQRMLYTFLHVIATHDLSSVFLTPKSRAYLDPMMQLVLNTSCNHKDITVRKACVQIFIKLIKDWCAEPYSEEKVPGFQNFVIEAFATNCCLYSVLDKSFNFSDANTHALFGEIITAQKVMYEKFGNTFLMHLMSKSFPSAHIPQDLAEQYCQKLQGNDIRSLKSYYQSLIENLRLQQNGSHVFR
Protein: Far upstream element binding protein 3 (A0A1W2Q698)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
IDGRVKQGASLGAPTAFGQSPFSQPPAAPHQNTFPPRAFPNIAAKVNGNPHSTPVSGPPAFLTQGWGSTYQAWQQPTQQVPSQQSQPQNSQPDYSKAWEDYYKKQGHTTSAAPQASSPPDYTMAWAEYYRQQAAFYGQTLGQAQAHSQEQ
Protein: Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) (O14974)
Organism: Homo sapiens (Human)
Function: Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12923170, ECO:0000269|PubMed:18477460}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:12923170}. Note=Also along actomyosin filaments. {ECO:0000269|PubMed:12923170}.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Protein phosphatase 1 regulatory subunit 14A
- Rho-associated protein kinase 1
- Transforming protein RhoA
- cGMP-dependent protein kinase 1
- Myosin regulatory light polypeptide 9
- Myosin regulatory light chain 12B
- Rho-associated protein kinase 2
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Sequence:
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK
Protein: Ascus wall glucan endo-1,3-beta-D-glucosidase (Glucan endo-1,3-beta-D-glucosidase 2) (Endo-1,3-beta-glucanase 2) (EC 3.2.1.39) (Laminarinase-2) (Q09850)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Cleaves internal linkages in 1,3-beta-glucan. Promotes the release of spores from asci by degrading the ascus wall.
Subcellular location: Ascus epiplasm {ECO:0000269|PubMed:19542306}. Cytoplasm {ECO:0000269|PubMed:25040903}. Note=Localizes to mobile dots in the cytoplasm. {ECO:0000269|PubMed:25040903}.
Interaction partners:
- Ascus wall endo-1,3-alpha-glucanase
- Protein csh3
- Cell fusion protein fus1
- Glucan 1,3-beta-glucosidase 3
- Zinc metalloprotease mde10
Sequence:
MDVLVPIYTGPINPVFPSRAHPSPPLGLTSNLFPIQTNKFYGNLYIGTRHNPSWSHPYSVTWLNGSSYYGLAISHIDDSQRVFGPDPESVPCQYYFNPAGLYSIIISAREFASGNLLSLDQSRHFSIQATLSATTSGSGTIILPIVAGMGFVSGYYTNLTPVFNSSILFSSITKINFSRGYKYRIQLTDGKIWFLYAFPTSSSSTFNLTLASNSQLTTSTKFTGLIQICKVPNESVNNSYPDTIYDASAGVYTTSISLSAQVSGTTGEYWFRFATAGYTNLNPLMFALPHHMQSFGSDTQAYKTGLGLASTTMGIMFAYATKTWHLIEKNLPTQVGFLPIPWNGGSNTYSPTALAAIRAACATDINFDVVNASNLDSMYTSGKIVAMYAQVCLVASRILGDSTLTNTGLTKLKQAMARFTTNTQMYPLVYDTTYKGIISTAGYSSPLADYGNTYYNDHHFHWGYHIYACAVIGLLDPSWLVNDNIRYVNALLRDSANPSESDTYFAMFRNFDWFVGHSWATGIFESGDGKDEESTSEDFNFLYATKLWGMVRNDTVLINRANLMLAVLKNSLNTYIYMTPTTSVQPSQILGNYVTGITFMNKVDYATYFSAEEYCKQGIHMIPTTPISGYLRSPSYVQQDWNAKIAPIINTFSNNWTGILWSNYAIYDPKTAYNTFAASTFTADKIDNGASKTWYLAMAAGMGGSP
Protein: At2g10940/F15K19.1 (Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein) (Expressed protein) (Q9SKI0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g04800
- GDSL esterase/lipase At1g09390
- GDSL esterase/lipase At5g62930
- GDSL esterase/lipase At2g42990
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- GDSL esterase/lipase At5g14450
- GDSL esterase/lipase LIP-4
- Aspartyl protease AED3
- Proline-rich protein 4
- GDSL esterase/lipase At3g48460
Sequence:
MDSSKLSSLSLCLFLICIIYLPQHSLACGSCNPRKGGKHSPKAPKLPVPPVTVPKLPVPPVTVPKLPVPPVTVPKLPVPPVTIPKLPVPPVTVPKLPVPPVTVPKLPVPPVTVPKLPVPPVTVPKLPVPPVTVPKLPVPPVTVPKLPLPPISGLPIPPVVGPNLPLPPLPIVGPILPPGTTPPATGGKDCPPPPGSVKPPSGGGKATCPIDTLKLGACVDLLGGLVKIGLGDPAVNKCCPLLKGLVEVEAAACLCTTLKLKALDLNLYVPVALQLLLTCGKNPPPGYTCSI
Protein: Epiglycanin (D9N008)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MRRRSSLWCWLLLQILLLGSXXYAHISSTTTSNPSSETKSIATDYETTPTTTISSTASGSMPTLTTKASSIASDSKPTLTTTASSTASGSMSTPTTPASSTASGSTPTTTTTASSTASGSTPTPTTPASSTASGSTPTPTTTASSKASRSVPTTVSSTGSGSTPTPTTTASSTASGSTPTLTTTPSSTASGSTPTPTTPASSTASGSSPTPTTPVSSTASGSTPTPTTTASSKASGSVPTTVSSTGSGSTPTLTTTVSSTVSDSTPTPTTTASSTASGSAPTPTTTASSTASGSTPTLTTTASSSGSGSTPTLPTTESSTASGSTPTRTTTTSSTASRSTPTPTTTASSTASGSTPTPTTTVSSTGSGSTPTLTTTASRSGSGSTPTLTTTESSTASGSSPTLTTTASSSASGSMPTPTTTASSTASGSSPTLTTTASSSASGSMPTLTTTASSSASGSSPTLTTTASSSASGSMPTPTTTVSSTGSGSTPTLTTTESSTASGSTPTWTTTTSSTASRSTPTPTTTASSTASGSTPTPTTTVSSTGSGSTPTLTTTASRSGSGSTPTLTTTESSTASGSIPTLTTAASSTASGSTPTPTTTASSTASGSMPTPTTTASSTGSGSTPTLTTTASSSGSGSTPTLTTTESSTASGSIPTLTSAASSSASGSMPTPTTTVSSTGSGSTPTLTTTASSSASGSMPTPTTTASSTASGSSPTLTTTASSSASGSAPNPTTTVSSTGSGSTPTLTTTASSSGSGSTPTLPTTESSTASGSTPTRTTTTSSTASRSTPTPTTTASSTASGSTPTPTTTVSSTASGSTPTLTTTASRSGSGSTPTLTTTESSTASGSTPTPTTTASSTASGSAPNPTTTVSSTASGSTPTLPTTASSSGSGSTPTLTTTESSTASGSSPTLTTTASSSASGSMPTPTTTASSTASGSSPTLTTTASSSASGSMPTLTTTASSSASGSSPTLTTTASSSASGSMPTPTTTVSSTGSGSTPTLTTTESSTASGSTPTWTTTTSSTASRSTPTPTTTASSTASGSTPTPTTTVSSTGSGSTPTLTTTASRRGSGSTPTLTTTESSTGSGSTPTLTTTASSSGSGSTPTLPTTESSTASGSTPTRTTTTSSTASRSTPTPTTTASSTASGSTPTPTTTVSSTASGSTPTLTTTASRSGSGSTPILTTTESSTASGSTPTLTTAASSSASGSTPTPTTTVSSTGSGSTPTLTTTASSSGSGSTPTLTTTESSTASGSTPTQTTTTSSTASRSTPTPTTTASSTASGSIPTPTTTASSIASGTTPTLTTTESSTASGSSPTPTTASSSSASDSKPTSTTTASSTVSDSTPTPTTNASSSASGSTPTQTTTASRSASGSVPTLTTIAFSTASGSTPTLTTTASNSASSSSPTPTTTGLSKTSASSLSLTSTMTSITSASTFTPASIRTSKASASTSTSASIRTSIAFASTSTPTTSGPSTASVSTLNSTSIRTSTGSSSSLSATHTSSSLTVSTGTHTTSNHTGTPVMEVKPSGSLKPWEIFLITLASVIVVMGLSAGLFIYVXRRYLSLRNAADGIFYNSHPDPGGSAMTPGSLTCSWRRPRTFNVVEMTRI
Protein: Anaphase promoting complex subunit 7, isoform A (Q9W3Y6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 4
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 2
- Cell division cycle 16
- Cyclosome subunit 8
- Shattered
- Anaphase-promoting complex subunit 13
- Mitotic spindle assembly checkpoint protein MAD2A
Sequence:
MASFLIVVEKMEIALFANAKKLYDHKLYECVIPAADLLRTVLKNDRYVATLDVEYQVLLYLLNANYKERNYRAALRHFDEIIHKRRLMMRHKNAVLVAIESSYPEFGDAEQRRRAAECYRQIGNTDMAIETLLQVPPTLRSPRINLMLARLQHHGSRHGTTKKSEAVLAYKEVIRECPMALQVIEALLELGVNGNEINSLVMHAATVPDHFDWLSKWIKALAQMFNFKHSDASQTFLMLHDNTTLRCNEHLMMALGKCLYYNGDYFQAEDIFSSTLCANPDNVEAIGLMAVLCGQEGGCEQDSADMDYLFAKVSSEVKYTASHWFAHAQLLYDEGKFERGLNFVEKCLDSEPRNHEALILRGRLLIALERHTQAVCAFRTAQMVAPYRFEIYRGLFHSYLAQKRFKEANALCNWTIRLFQNSPRSFTMFGRTLFLFPDPRMRRTARKFAEKSLKINHIYTPAVNLIADICQVEGPTKAIIKLLEKHVIIFPKVNLLNHLGDIMRKQKEPVKAMEYYYKALRQDPKSKRTLRGLRLLAKSDDESPVLDESDDIGMDNQQSINDLTTLCEATNAQGAEGAESVENSREASSSAAARSGQEEDVDEHDWIDVPDGMSY
Protein: AT5g47580/MNJ7_17 (Transmembrane protein) (Q9FGJ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGILGCDAHGDLNDAEFSKPLPSIGIYVAVASLICGLAMAADLIHGFRHRKFWFPCKFFSLNATSLTFIAVGIKLSVDLNTSMPSRQDQLAKLSSTVFVCTVMGNSMPSLGIMDNNDLLMNLMALGILVITDVVNICIQLGTGAIYVFSEEHFLVVLLMLLMLMILCFSATTVPTTKRILESKYNKRYDVAMKCPLATERTVAKKIQQDLSKFWMMAHTSSPQFVMARSVTCTASGFFCLLSAITLGEAMVRSYFLRPRSLGFCHGDSDYKWSTSLVLVCQTTTVAIGTIAPAIRWFTAVNFRCPIRGKKYYRDEFRIESYWTHWFSEKKQHPLSLWILKERRYRKTAHNAKRWILDVCIVIQYVIVFGSKIIRYISVSCVGKILLCCHFALRTSNTITHSESEKSDSNPSSRQDLASFVLHLEGEDPLVDVMVRSNREATDHWIEKGRKKQPVNLIELLEATTPISKGFEGIAEFDSNKVASLAHGEPPNCWALPLVTLTSIAVALPDIKPSSLKKLLNAVNEALEYVNKFECVLDTGGESVNLRKAAEVVWLGVDLYHKWFDVDLRKLSKQQRNPEETLRELMEIAKKEFSESWQMNLMVCMKHKPSHWPIKTLAANSMYRICQTILLTYESRDYGTGEALLRKLESTISDIVSGCFCNVAQVISVKCLVSAVEVREESVRGAALHLGRTEKILEILERRRLPKLRCDQMKNIDEWRAFYKINSCECDNNNKTVYPDSDELRLTVE
Protein: Global nitrogen regulator NrpRII (Nitrogen regulatory protein R II) (Q8PVJ4)
Organism: Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Function: Involved in nitrogen regulation. Under nitrogen sufficiency, represses the transcription of the nifH and the glnk1 promoters, via formation of a complex with the global nitrogen regulator NrpRI. Does not bind DNA directly.
Interaction partners:
Sequence:
MQKNGYRIQFTSSRIRDLMYRTTFDPKKMDGDIILNLSLIDKKDLDDVLGIFKMVISSGLSVTPYVKVISEGESIGDMTIEKGKVGIGTVCSITIDGVLLKAGIPVNPKLGGVVQIRNGIPVRFTDVLTYVSTTVDPLEILMSQGITSVSEMLRTGSGKVLANLREAPMVARDEIESNLSDLLDAGFSGILEVGEPNTRVLDVPIERDHLGIVVIGGTNPMAVVQEYGIPIDTSAMSRLISFKEMSRIEDLV
Protein: Remodeling and spacing factor 1 (H0YCN2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
ETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKK
Protein: Thioredoxin domain-containing protein 3 (3'-5' exonuclease NME8) (EC 3.1.-.-) (NM23-H8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2) (Sptrx-2) (Q8N427)
Organism: Homo sapiens (Human)
Function: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11737268}.
Interaction partners:
- Dynein axonemal intermediate chain 1
- Dynein axonemal intermediate chain 2
- Dynein axonemal heavy chain 5
- Dynein axonemal heavy chain 11
- Outer dynein arm-docking complex subunit 1
- Radial spoke head protein 4 homolog A
- Radial spoke head protein 9 homolog
- Protein kintoun
- Dynein axonemal assembly factor 1
- Dynein axonemal heavy chain 1
Sequence:
MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKIAAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTSGLSYILVVSQGSKHNPPSEETEPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFMDAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
Protein: chitin synthase (EC 2.4.1.16) (Q6FQN4)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- UDP-N-acetylglucosamine diphosphorylase
Sequence:
MVMTAIAGDKFLYPKLNKIVPFTLFSHHSPDLENPLLESELNTTENTKESISVINPGSKKRHKARCRRNGRNELFQSKVRGWHFYCRVVTIFIPSKVLKFCGIRTVEQQRAWREKVGLISIILAIGAIVIYISFIFTNTACGYKQPKILHRNVSDSFIRINGRAYPFNWANIPESTPILISYYGLFAPKSYGGKDASLLFQNVNGNCHGIIKPRENCTIPHDNNGNLAWYFPCVVLSKDDYMSWDPEIEIENKPSNCHISEFERDSYYYLEYPVNIYYTWDDIKNSNRSLVVYNNYVLDLKILQMLYKYDLDVPPKLLELGSLPINGYDISVTLTTNYDKKLARCLIDIATVGLIDAEPLGCIVANIILYLFLIFIMSIVILKFVIACYFRWVVAKAQGSFKVNNKTMIRIMRDIEDWAEDINKKAPIMNVNFLPENTSLITRKRDIVEGISLHPKRMSNPTSILSGPNSSNVKSTTYLKPNLKIGNSISQNFDSFIRKGENYCLCSFPETSNYRDSLLKSLNDGNLDPSIIHKNVVKPNNIIHGSSDGFLNTICFVTCYSEGVRELRSTLDALCTTTYPNTHKLIILVCDGQVTGAHNKKLTSEIALNMITDFIEDPNEVIPYSYLSIASGAKRFNMAKVYGGYYKYDSDTVEESQQQQVPIVLVSKCGSFYEIHSSPKPGNRGKRDSQIILMSLLQRAICNERMSELEFQLLKVIWQVGGKMIMEYETVLMVDADTRVFPDSIRHMCAEMAKDTNIMGLCGETKIANKKESWVTAIQVFEYYISHHHSKAFESIFGSVLCLPGCFSMFRIKSPKDKEQTCWVPILANPDIVECYSNNSTDTLHQKNLLLLGEDRYLSSLLLRKFPNRKQVFVPKAACKTVVPSKFLVLLSQRRRWINSTIHNLVDLLRHDNLCGTFCFSMQFVVLLELLGTILLPFAILSTIYVIIYSALFAPLPMLTLVLLLVILGLPGVFIVITTTKLVYVVWMLVYLVALPIWNLILPVYAFWKFDDFSWGETRATKDGKRNDINETADTFNHTAVNMMTWKEHALDEKARGSRYPFAV
Protein: Stem cell tumor, isoform B (EC 3.4.21.-) (Q9W0E9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- DnaJ-like-2, isoform A
- Ras-like GTP-binding protein Rho1
- Protein spitz
- Protein gurken
Sequence:
MWPGSERGSSRALEIPTSQQNAGGSSQQETLADIEHISTIAGSLASIGSLSHTQMRYQCTNDAGYDTEHTSLNSDFDEAELRRELLRDKWKLLFDMFDPEGFGEISVEEFLEALKSPEFLSQVPMNKRELLLERAKKAKLPTGPGYVTFQDFVNVMSGKRTRSFKCAVHHRDREVCSENDFQLVLNEPPLFRKMVHAVAMEILPEERDRKYYADRYTCCPPPFFIILVTLVELGFFVYHSVVTGEAAPRGPIPSDSMFIYRPDKRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPDVFLVGASGGVYALLAAHLANVLLNYHQMRYGVIKLLHILVFVSFDFGFAIYARYAGDELQLGSSSEFLAIDQAETAGAVSYVAHLAGAIAGLTIGLLVLKSFEQKLHEQLLWWIALGTYLALVVFAIAFNIMNGFAMFNIRVEKIRVTETIFNDFQV
Protein: High osmolarity signaling protein SHO1 (Osmosensor SHO1) (Q5AQ36)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Mediates resistance to oxidative stress. Controls the activation of the CEK1 MAP kinase. Influences the molecular weight and polymer distribution of cell wall mannan. Involved in invasive filamentation into semi-solid medium and plays a role in morphological dimorphic transition which is a differentiation program characteristic of C.albicans and which is known to play a major role in pathogenesis.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- mitogen-activated protein kinase kinase
- Cell division control protein 42 homolog
- mitogen-activated protein kinase kinase kinase
- Ste50p
- Mitogen-activated protein kinase HOG1
- Serine/threonine-protein kinase CST20
- Rho family guanine nucleotide exchange factor
- Histidine protein kinase SLN1
- Oxidative stress response two-component system protein SSK1
- Vacuolar protein sorting-associated protein 27
Sequence:
MGFSLSNFTSDPFAISTVSFGIMAWVVAIAGAASSKQENFPHFSWWGISYQIVIILIIFVLYANNNIELYKFTLVGLVSIAFIYTTNSTNNLIYNSNSAGNLCCAAGCILLSILNLIWILYFGGHPESPTNQFIDSFSLRGQGHEQLGSGSHNHNANNANNNIPIGAGNAIIGKGEMSPYDDRFAASGVNQPTSESLRLASGPQMGNGPFTTTGAIINPNLQQPLSGSIGGSAHHTPTNINNNNNNNNNTGYMTSSHLTGLENFSSPHVPGSGAGAGLGVGAGRDLTHNSNGGGGGSGGGPASANNSNNTNKRNTIYTDSETGTGITFRYKAKALYSYDANPDDINEISFVKDEILEVDDIDGKWWQARRANGQVGICPSNYVKLLDT
Protein: Tubulointerstitial nephritis antigen-like (Adrenocortical zonation factor 1) (AZ-1) (Androgen-regulated gene 1 protein) (Tubulointerstitial nephritis antigen-related protein) (TARP) (Q99JR5)
Organism: Mus musculus (Mouse)
Function: May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein.
Subcellular location: Secreted.
Interaction partners:
- Disks large homolog 4
- Glutamate receptor 1
- Voltage-dependent calcium channel gamma-2 subunit
- Protein cornichon homolog 1
- Glutamate receptor 2
- Voltage-dependent calcium channel gamma-8 subunit
- Protein shisa-9
- Glutamate receptor 3
- Protein cornichon homolog 2
Sequence:
MWGCWLGLLLLLLAGQAALEARRSRWRRELAPGLHLRGIRDAGGRYCQEQDMCCRGRADECALPYLGATCYCDLFCNRTVSDCCPDFWDFCLGIPPPFPPVQGCMHGGRIYPVFGTYWDNCNRCTCHEGGHWECDQEPCLVDPDMIKAINRGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSTVMNMNEIYTVLGQGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPILSPQNLLSCDTHHQQGCRGGRLDGAWWFLRRRGVVSDNCYPFSGREQNEASPTPRCMMHSRAMGRGKRQATSRCPNGQVDSNDIYQVTPAYRLGSDEKEIMKELMENGPVQALMEVHEDFFLYQRGIYSHTPVSQGRPEQYRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPWWGERGHFRIVRGTNECDIETFVLGVWGRVGMEDMGHH
Protein: Salviol synthase (EC 1.14.14.62) (Cytochrome P450 71BE52) (SpCYP71BE52) (A0A0S1TQ04)
Organism: Salvia pomifera (Apple sage)
Function: Monooxygenase involved in the biosynthesis of labdane-related diterpenes natural products. Catalyzes the oxidation of ferruginol to produce salviol. Salviol is an intermediate in the biosynthesis of carnosate, a potent antioxidant.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MEIHIPSLVLCISFFIFFKIVSKLKTKTSNRKHLPLPPGPWKLPLIGNLHNLVGALPHHTLRRLSRKFGPMMSLQLGELSAVIISSADAAKEIMKTHDLNFASRPQVAAADIIGYGSTNITFSPYGGHWRQLRKICTLELLSAKRVQSFRPLRERVFVDLCRRFADHGSSAVNFSEEFMSATYTLISRAVLGEEAEQHEGLLPNVKEMPELTAGFDISEVFPSVGLFKVMSRLRKRIVAVHKDTDRILDDVIHQHRAAKSEEHKDLLDVLLQLQEDGLELPLTDENIKSVLVDMLVAGSETSSTVIEWAMAEMLKNPRILEKAQEEVRRVFDKEGTVDESHIHELKYLKSVVKETLRVHPPAPLILPRICGETCEINGYEIPAETKIIVNAWAVNRDPKYWEDSDCFKPERFLDNLVDFRGNHFQYIPFGAGRRMCPGIGFGLANVELPLAMFMYHFDWELDGGMKPQDLDMEEKFGASAKKLKDLFLIPAIKRTLPTK