wanglab/gogpt-training-data huggingface dataset:
Protein: Exocrine gland-secreting peptide 8 (A8R0U1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MTSFPVMLFLIILLLPSICSEERTQADPTISADNKKNFKTVVDLTDCQCERNFIESLESTLPASNQDQTLFENMTNQHKLNLSKMLSVLSKCCTQKQQVDTVHFRRMPHRIQSTKQNNYKKQVLYPMQEFMNLTRDVLVSRYV
Protein: Metastasis-associated protein MTA3 (Q9BTC8)
Organism: Homo sapiens (Human)
Function: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Cytoplasm {ECO:0000250|UniProtKB:Q924K8}.
Interaction partners:
- Histone-binding protein RBBP7
- Histone deacetylase 1
- Histone-binding protein RBBP4
- Chromodomain-helicase-DNA-binding protein 4
- Chromodomain-helicase-DNA-binding protein 3
- Histone deacetylase 2
- Transcriptional repressor p66-alpha
- Transcriptional repressor p66-beta
- Metastasis-associated protein MTA1
- Methyl-CpG-binding domain protein 3
Sequence:
MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYSKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGYLEIHPAKKPNVIRSTPSLQTPTTKRMLTTPNHTSLSILGKRNYSHHNGLDELTCCVSD
Protein: Signal peptide peptidase like 2A (H0YNA2)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Membrane {ECO:0000256|ARBA:ARBA00004366}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004366}; Lumenal side {ECO:0000256|ARBA:ARBA00004366}.
Interaction partners:
Sequence:
XALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKNDGNLVEATGQPSAPHEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ
Protein: Large ribosomal subunit protein uL5m (54S ribosomal protein L7, mitochondrial) (YmL5) (YmL7) (P36519)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Interaction partners:
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL6m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL15m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein uS14m
- Small ribosomal subunit protein uS11m
Sequence:
MQRFSLVTHRSFSHSCVKPKSACSLVKPVHHLVKIDKSKLSPRFPELKYDKSDIRSPGFKPKDTHADRLNDHYLNTLQSDLLLINYSHNAAVVKGLKQRAWSGDSPYHLNRPPKNPRGSKAQLPDIHPIKWSNIPGLESVVINCFVREARENQLLAITAALQLQQITGCKPHPIFSKNDVPTWKLRKGHQMGAKVELKGKEMSQFLSTLTEIVLPRIREYKGISNQSGNRFGGISFGLTAEDIKFFPEIDANQDSWPKTFGMHININTSAQLDYQARTLLSGFQFPFFGEEK
Protein: Tyrosinase (EC 1.14.18.1) (Monophenol monooxygenase) (Q00234)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Interaction partners:
- Tyrosinase copper-binding domain-containing protein
- tyrosinase
- tyrosinase
- Tyrosinase copper-binding domain-containing protein
- Tyrosinase copper-binding domain-containing protein
- Tyrosinase copper-binding domain-containing protein
- Tyrosinase copper-binding domain-containing protein
- Aromatic-L-amino-acid/L-histidine decarboxylase
- aromatic-amino-acid transaminase
- histidinol-phosphate transaminase
Sequence:
MASVEPIKTFEIRQKGPVETKAERKSIRDLNEEELDKLIEAWRWIQDPARTGEDSFFYLAGLHGEPFRGAGYNNSHWWGGYCHHGNILFPTWHRAYLMAVEKALRKACPDVSLPYWDESDDETAKKGIPLIFTQKEYKGKPNPLYSYTFSERIVDRLAKFPDADYSKPQGYKTCRYPYSGLCGQDDIAIAQQHNNFLDANFNQEQITGLLNSNVTSWLNLGQFTDIEGKQVKADTRWKIRQCLLTEEYTVFSNTTSAQRWNDEQFHPLESGGKETEAKATSLAVPLESPHNDMHLAIGGVQIPGFNVDQYAGANGDMGENDTASFDPIFYFHHCFIDYLFWTWQTMHKKTDASQITILPEYPGTNSVDSQGPTPGISGNTWLTLDTPLDPFRENGDKVTSNKLLTLKDLPYTYKAPTSGTGSVFNDVPRLNYPLSPPILRVSGINRASIAGSFALAISQTDHTGKAQVKGIESVLSRWHVQGCANCQTHLSTTAFVPLFELNEDDAKRKHANNELAVHLHTRGNPGGQRVRNVTVGTMR
Protein: F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19) (Q6PCT2)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23512198, ECO:0000269|PubMed:23871831, ECO:0000269|PubMed:29522376}. Nucleus {ECO:0000269|PubMed:29522376}.
Interaction partners:
- S-phase kinase-associated protein 1
- Cullin-1
- Nucleus accumbens-associated protein 1
- Lysine-specific demethylase 7A
- Ubiquitin-like protein NEDD8
Sequence:
MGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS
Protein: Cation channel sperm-associated auxiliary subunit TMEM262 (Cation channel sperm-associated auxiliary subunit eta) (Transmembrane protein 262) (D3Z338)
Organism: Mus musculus (Mouse)
Function: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000269|PubMed:34225353}.
Interaction partners:
- Cation channel sperm-associated auxiliary subunit beta
- Cation channel sperm-associated auxiliary subunit TMEM249
- Cation channel sperm-associated protein 4
- Cation channel sperm-associated auxiliary subunit epsilon
- EF-hand calcium-binding domain-containing protein 9
- Cation channel sperm-associated protein 1
- Cation channel sperm-associated auxiliary subunit delta
- Cation channel sperm-associated protein 2
- Solute carrier organic anion transporter family member 6C1
- Cation channel sperm-associated auxiliary subunit zeta
Sequence:
MRWRDRIAVLCFPPGLMLTVAALILFFIHMGVFASDVHNFCVIHNYDHMSFRYTVVLIFSQVISIGWAAMGSLYAEMTGDKFLRCFALTILILNGAMFFNRLCLEFLAINYREERH
Protein: Transcription initiation protein SPT3 homolog (Q8BU36)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MNNAAASPMSTTTSSSGRNAGKTISFAAELQSMMFSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIIKGIDEDDLLEEKLSGSSGTNKRQKIAQDLINSIDQTGELLAMFEDNELDDVKQERMERAERQTRTMDSAQYAEFCESRQLSFSKKASKFRDWLDCSSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVSKAGDPFSHAISATFIQYHSSAEGSSCLKSSPDSPENTPPPTPTAPSSGSQHSGRAASGSLGNGNTGQDTAKTKQRKRKKSTAACGVEAHSDAIQPCHIREAIRRYGHKIGPLSPFTSAYRRSGMAFLAC
Protein: Nucleosome assembly protein 1-like 2 (Brain-specific protein, X-linked) (Q9ULW6)
Organism: Homo sapiens (Human)
Function: Acidic protein which may be involved in interactions with other proteins or DNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein CDX-4
- Nucleosome assembly protein 1-like 3
Sequence:
MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDDGKCGEEAAAGLGEEGENGEDTAAGSGEDGKKGGDTDEDSEADRPKGLIGYVLDTDFVESLPVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYEPTEEECEYKSDSEDCDDEEMCHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEEEEEDDIEATGEENKEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGITSNGRDGNDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDAIYDKIIYDNWMAAIEEVKACCKNLEALVEDIDR
Protein: ETHYLENE INSENSITIVE 3-like 5 protein (Q9FJQ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Putative transcription factor that may be involved in the ethylene response pathway.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- EIN3-binding F-box protein 1
- Ethylene-responsive transcription factor 2
- Ethylene-insensitive protein 2
- Mitogen-activated protein kinase 3
- EIN3-binding F-box protein 2
- Mitogen-activated protein kinase 6
- Ethylene-responsive transcription factor 1B
- Mitogen-activated protein kinase 10
Sequence:
MVEVQDLEPLSPIQDYDEDDLEEDVDEFERFGEEISYDDLKKRMWKDRNLMCKLKQQKRDNLNSVISSPSSSTSASSSSSSSVIVRRTEASRRKKMARSQDSVLKYMMKIMEVCKAQGFVYGIVPEKGKPVTGSSDSLRRWWKENVQFDQTAPNAVSDYLTLAAAQLISSNESLDPNSYIHMLHELQDTTLGSLLSALMQHCVPPQRRFPLEKGLAPPWWPNGTELWWGEQGAAAFEHGPPPYRKPHDLRKAWKVSVLAAVIKHMSPNLERVRRLARQSKCLQDKMMAKETDTWSRVLNQEEARLNRLKISDDEDEDRDQEQARFTCFDQEPSLNTCFIVGQDQEPLGSMRKDKRVDQEFSSNDCFLVAQDQEPRKGKKADQEWSPNSCFLVDQEPLGNKRKGEFVEKEAMLSNVYTCQNSSCPSSDVSLGFVDKNLRTGHEIECLYGTPELVNQSSGGGSDGFVRSITTSDDDYSASSKAEDTRDYHNQDGNWLDYLWFERLHDLNFSDQGFEDQTSTVDLNQLPDHSDSNQTMNEDDISLWDMGCEDKDIYMSQD
Protein: Beta-tectorin (Q96PL2)
Organism: Homo sapiens (Human)
Function: One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}; Extracellular side {ECO:0000305}. Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane. {ECO:0000250}.
Interaction partners:
- Otogelin
- Otoancorin
- Zonadhesin
- Cochlin
- Cell adhesion molecule CEACAM16
- Nidogen-1
- Otogelin-like protein
Sequence:
MVTKAFVLLAIFAEASAKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFVLEASEIGSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGRDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGGVLVVELSLRSRGFSSLYSFSDVLHHLIMMLGICAVL
Protein: Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VGR-1) (P20722)
Organism: Mus musculus (Mouse)
Function: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (By similarity). Also plays an important role in the regulation of iron metabolism by acting as a ligand for hemojuvelin/HJV. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P22004}.
Interaction partners:
- Bone morphogenetic protein receptor type-1A
- Activin receptor type-1
- Bone morphogenetic protein receptor type-2
- Bone morphogenetic protein receptor type-1B
- Activin receptor type-2A
- Activin receptor type-2B
- Hemojuvelin
- Noggin
- Bone morphogenetic protein 4
- Chordin
Sequence:
MPGLGRRAQWLCWWWGLLCSCGPPPLRPPLPVAAAAAGGQLLGAGGSPVRAEQPPPQSSSSGFLYRRLKTHEKREMQKEILSVLGLPHRPRPLHGLQQPQPPVLPPQQQQQQQQQQTAREEPPPGRLKSAPLFMLDLYNALSNDDEEDGASEGVGQEPGSHGGASSSQLRQPSPGAAHSLNRKSLLAPGPGGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPHQRHHKEFKFNLSQIPEGEAVTAAEFRVYKDCVVGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGLHVNPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVSRGSGSSDYNGSELKTACKKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
Protein: Histone H3-like centromeric protein CSE4 (CENP-A homolog) (CENPA homolog) (Q59LN9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P36012}. Chromosome, centromere {ECO:0000250|UniProtKB:P36012}.
Interaction partners:
- Histone H4
- Histone H2A.Z
- C2H2-type domain-containing protein
- Chl4p
- Aurora kinase
- Probable kinetochore protein NUF2
- CENP-C homolog
- [histone H3]-trimethyl-L-lysine
- [histone H3]-trimethyl-L-lysine
- Histone H2B.1
Sequence:
MARLSGQSSGRQTGQGTSAEAIRQQREELRRQRELRLQQQQQAERQQQRQQYRTEQSPIVPAATSSSRYSQFGIYRNQPGDVVDTLASSLPRRTTTTRPEVNRTVPRVKKRYRPGTKALREIRQYQKSTDLLIRKLPFARLVREISLDFVGPSYGLRWQSNAILALQEASESFLIHLLEDTNLCAIHAKRVTIMQKDIQLARRIRGQSWIL
Protein: Insulin-like growth factor-binding protein 1 (C9JXF9)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQTSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN
Protein: Plasma membrane-associated cation-binding protein 2 (AtPCAP2) (Lysine rich protein At168) (Microtubule-associated protein 18) (Q9LU05)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in intracellular signaling through interaction with PtdInsPs and calmodulin (CaM); may keep PtdInsPs attached to the plasma membrane until Ca(2+)-CaM reaches a competitive concentration subsequent to an increase triggered by a stimulus, thus leading to PtdInsPs release and subsequent activation of InsPs-dependent signaling cascade (Probable). Binds to microtubules and inhibits tubulin polymerization. Regulates directional cell growth and cortical microtubule organization by destabilizing microtubules (e.g. in cotyledon pavement cells).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20061304}; Lipid-anchor {ECO:0000269|PubMed:20061304}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17337629}. Note=Localized along cortical microtubules as patches of dot-like structures. {ECO:0000269|PubMed:17337629}.
Interaction partners:
- Plasma membrane-associated cation-binding protein 1
- CLIP-associated protein
- Microtubule-associated protein 70-1
- Cytosolic sulfotransferase 9
- Protein WAVE-DAMPENED 2
- Protein SPIRAL1
- Phosphatidylinositol 4-phosphate 5-kinase 3
- Methionine aminopeptidase 1C, chloroplastic/mitochondrial
- Expansin-A7
- Kinesin-like protein KIN-13A
Sequence:
MGYWKSKVVPRMKKLFEKSPAKKEVVEEEKPREVEVVEEVVVKTEEPAKEGETKPEEIIATGEKEIEIVEEKKEEAKPVEVPVLAAAEEKKPAVEEEKKTAPVEEKKPAVEEEKKPAVEEKKPVEEEKKEVVAAVPVAETPSTKAPETPVVETPAKAPETPAAAPQKA
Protein: Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) (Q9I5G7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
- Elongation factor 4
- Lipoprotein signal peptidase
- Signal peptidase I
- Protein translocase subunit SecY
- Membrane protein insertase YidC
- Outer membrane protein assembly factor BamA
- Ribonuclease 3
- Protein translocase subunit SecA
- Outer membrane protein assembly factor BamD
- Sec translocon accessory complex subunit YajC
Sequence:
MTLNFPLLLVIAVAVCGALALVDLVLFAPRRRAAISSYEGQVNEPDPAVLEKLNKEPLLVEYGKSFFPVLFIVLVLRSFLVEPFQIPSGSMKPTLEVGDFILVNKFAYGIRLPVLDTKVIPIGDPQRGDVMVFRYPSEPNINYIKRVVGLPGDTVRYTKEKRLYVNGELVAEKLVGEEPGTLGSVTLYQEKLGQAEHLIRKEMSRYRIEPDRQWTIPAGHYFMMGDNRDNSNDSRYWNDPKIPKDLLGMVPDRNIVGKAFAVWMSWPDPKMSNLPNFSRVGVIH
Protein: Small ribosomal subunit protein mS42 (37S ribosomal protein S26B, mitochondrial) (O74379)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P10662}.
Interaction partners:
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein bS18m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein uS17m
- Small ribosomal subunit protein uS4m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein mS23
Sequence:
MSFQQRFARALDVGYKNFLSKDAVRNIFAYDNHLRGLVQKECKIHQTPYRVPSDLMVQSASDPARANLFNYSSQLVNHDFFFSGLISPERPSADADLGAINLKPGIDASFGSFGELKSQMVDVGNSVFGDGWLWLVYSPEKSLFSLLCTYNASNAFLWGTGFPKFRTNAIVPLLCVNLWQYAYLDDYGLNGKKMYITKWWDMINWTVVNNRFQATRIESL
Protein: Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13) (Q8CF93)
Organism: Mus musculus (Mouse)
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor. Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures. Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system. Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC. Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain (By similarity). May promote neurogenesis through glycosylation and stabilization of PDPN.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- C1GALT1-specific chaperone 1
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Sequence:
MRRFVYCKVVLATSLMWVLVDVFLLLYFSECNKCDDKKERSLLPALRAVISRNQEGPGEMGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEGCKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLKLTLENYVKTLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQIPRRYYSLGEIRNVETNQCLDNMGRKENEKVGIFNCHGMGGNQVFSYTADKEIRTDDLCLDVSRLSGPVIMLKCHHMRGNQLWEYDAERLTLRHANSNQCLDEPSEEDKMVPTMQDCSGSRSQQWLLRNMTLGT
Protein: Lipolysis-stimulated lipoprotein receptor (Angulin-3) (Lipolysis-stimulated receptor) (Liver-specific bHLH-Zip transcription factor) (Liver-specific gene on mouse chromosome 7 protein) (Q99KG5)
Organism: Mus musculus (Mouse)
Function: Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells. Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21245199}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:24889144}. Note=Located at tricellular contacts. {ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:24889144}.
Interaction partners:
- MARVEL domain-containing protein 2
- Apolipoprotein B-100
- Apolipoprotein E
Sequence:
MAPAASACAGAPGSHPATTIFVCLFLIIYCPDRASAIQVTVPDPYHVVILFQPVTLHCTYQMSNTLTAPIVIWKYKSFCRDRVADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDSGVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASLLFFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMRPPYGYPGDFDRTSSVGGHSSQVPLLREVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPRSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDLRSRDPRADPRSRQRSHDPRDAGFRSRDPQYDGRLLEEALKKKGAGERRRVYREEEEEEEEGHYPPAPPPYSETDSQASRERRMKKNLALSRESLVV
Protein: Ubiquitin-conjugating enzyme E2 variant 3 (UEV-3) (EV and lactate/malate dehydrogenase domain-containing protein) (Q8IX04)
Organism: Homo sapiens (Human)
Function: Possible negative regulator of polyubiquitination.
Interaction partners:
- Vacuolar protein sorting-associated protein 28 homolog
- Gamma-glutamyl hydrolase
- Citrate synthase, mitochondrial
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- Multivesicular body subunit 12B
- Vacuolar protein sorting-associated protein 37A
- Multivesicular body subunit 12A
- Vacuolar protein sorting-associated protein 37D
- Vacuolar protein sorting-associated protein 37C
- Vacuolar protein sorting-associated protein 37B
Sequence:
MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYVFKDSSQKDLLNFTGTIPVMYQGNTYNIPIRFWILDSHPFAPPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHPKSVIVGLIKEMIAKFQEELPMYSLSSSDEARQVDLLAYIAKITEGVSDTNSKSWANHENKTVNKITVVGGGELGIACTLAISAKGIADRLVLLDLSEGTKGATMDLEIFNLPNVEISKDLSASAHSKVVIFTVNSLGSSQSYLDVVQSNVDMFRALVPALGHYSQHSVLLVASQPVEIMTYVTWKLSTFPANRVIGIGCNLDSQRLQYIITNVLKAQTSGKEVWVIGEQGEDKVLTWSGQEEVVSHTSQVQLSNRAMELLRVKGQRSWSVGLSVADMVDSIVNNKKKVHSVSALAKGYYDINSEVFLSLPCILGTNGVSEVIKTTLKEDTVTEKLQSSASSIHSLQQQLKL