Protein: Location of vulva defective 1 (Polycystic kidney disease 1 protein homolog) (Polycystin-1) (Q09624)
Organism: Caenorhabditis elegans
Function: Required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as pkd-2 and atp-2 in response behavior. May be required for ciliary targeting of pkd-2.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:17581863}. Note=localizes to both the ciliary base and cilium proper.
Interaction partners:
- Polycystin-2
- CILiary localization
- Kinesin-like protein
- Intraflagellar transport protein 20 homolog
- BBSome complex member BBS1
- Nephrocystin-1-like protein
- NePHronoPhthisis
- Secreted protein
- Intraflagellar transport protein 88 homolog
- Signal transducing adapter molecule 1
Sequence:
MKKSNFFVLLLLAISAIQIDGLHYQLLDGIATFRLDNDDTTIGGVPRNSQGVVKIKLSCGLNRLSVENKVTEVSSLELIHNCIQTETRLVGLFLNSTWITLNEVNDDDEISIAVEAKYEVCYDDGIDRCDGSLWWLQVGGNEMALLGYREKCESGEINEEYARRMCKRPYRSEKSTAISDSQGVYYDGQVLKGVRAKQFSMRTSGSPTLRRMKRDAGDNTCDYTIESTSTSTTTPTTTTVTSTVTSTTTVPTSTSTVTTAMSTSTSTPSTSTTIESTSTTFTSTASTSTSSTSTTQQSSSTITSSPSSTTLSTSIPTTTTPEITSTLSSLPDNAICSYLDETTTSTTFTTTMLTSTTTEEPSTSTTTTEVTSTSSTVTTTEPTTTLTTSTASTSTTEPSTSTVTTSPSTSPVTSTVTSSSSSSTTVTTPTSTESTSTSPSSTVTTSTTAPSTSTTGPSSSSSTPSSTASSSVSSTASSTQSSTSTQQSSTTTKSETTTSSDGTNPDFYFVEKATTTFYDSTSVNLTLNSGLGIIGYQTSIECTSPTSSNYVSTTKDGACFTKSVSMPRLGGTYPASTFVGPGNYTFRATMTTDDKKVYYTYANVYIQEYSSTTIESESSTSAVASSTSSTPSTPSSTLSTSTVTEPSSTRSSDSTTTSAGSTTTLQESTTTSEESTTDSSTTTISDTSTTSSSPSSTTADSTSTLSVDQFDFILDSGLSWNETRHNEDSINIVPLPTNAITPTERSQTFECRNVSTEPFLIIKESTCLNYSNTVLNATYSSNIPIQPIETFLVGIGTYEFRINMTDLTTMQVVSHIFTLNVVADSTSTSEVTSTTSTGSSSESSAISTTSGIESTSTLEASTTDASQDSSTSTSDSGTTSDSTTIDSSNSTPSTSDSSGLSQTPSDSSSASDSMRTTTVDPDASTETPYDFVLENLTWNETVYYSENPFYITPIPNKEPGALTTAMTCQCRNDSSQPFVLLKESNCLTEFGKNGAYSASVSFNPMTSFVPATGTYEFLINVTNRASGESASHIFTMNVVLPTTTTETPPTTVSSSDDAGGKTGGTGATGGTGGTGSGGSATTLSTGDAVRSTTSGSGSGQSSTGSGAGGSGTTASGSGSGGSSGTGSDGVNSGKTTALNGDGTGSGTATTPGSHLGDGGSTSGSGSDSNGSSGVSTKSSSGSDTSGSSDSSGANGAFSATAQPSTRTTKTRSSLATVSPISAAEQAIIDAQKADVMNQLAGIMDGSASNNSLNTSSSLLNQISSLPAADLVEVAQSLLSNTLKIPGVGNMSSVDVLKTLQDNIATTNSELADEMAKVITKLANVNMTSAQSLNSVLSSLDLALKGSTVYTLGVSSTKSKDGTYAVIFGYVIASGYTLVSPRCTLSIYGSTIYLTGDTRASYKQLDGDTVTADTMLAAAIGIQGMFATNGRTVQVEQDKIDDKRSLVSGNIMATMSGVGDVQSGEYSYNDMYVTAWNVTYDNSTVGSTSQKNTSFSFNIPVSEVQYILLIESGTMIKLHSTQNIVSRGLVVTASYGGVTYTITCTNGTGKFVEVDTDNAIFSYNADSFTVVASDGSSASTVKKLIQMPIVIENVNLALFNQTTSPLVFSNAGSYSMRMVLSPQDIGIPAVSALSQTVSISTLSPTASYTKDDLQSLIKEQTLVTVSGTLFFSKASSIDVSGYSFFVDSTALYLSNSVTTLVISSPTYNIVSLALGGYGIQITAGTYTSGSQTHTVTLMEFSDTQKMRIDGGLIIRNGTNGYVIQNGQVSTEGDVSGTKIDIVPQSLMNQESQQQIETILSNTQDFLTNNGMTMTDAEINDTSNSLLSIAGSLTSALKIALDNPLSSDLAANLKYATDNYDSLYNVLPSDPDNIVYVEEMTSEEWAAYVTKMFQKNIAKNLANQLASTLDTLENTLAARAIATGNLPYDYSNSVDGTGMVIVIDDASNIVGKTQNCEEWAFKLPSPASTLNTAEITDKTLIQVGLVCYATNPRTYVDNFDMLITSGALEAHIKDENQIIIPITGTTAPIYVNGRGSEDDAVLTLMQQGDFASYQILDLHAFRTTNWNNSLQVEIIASQDYEIPNNDDTYMFSSFQSLPGPLESNHEWIFDLNTLNKTSNYFVTAGNLINNTGLFFIGIGKRNSSTNTGNSSDIVNYGQYDSMQWSFARSVPMDYQVAAVSKGCYFYQKTSDVFNSEGMYPSDGQGMQFVNCSTDHLTMFSVGAFNPTIDADFSYNYNVNEIEKNVKVMIAAVFMLVVYGCLTINAIICQRKDASRGRLRFLKDNEPHDGYMYVIAVETGYRMFATTDSTICFNLSGNEGDQIFRSFRSEEDGNWEFPFSWGTTDRFVMTTAFPLGELEYMRLWLDDAGLDHRESWYCNRIIVKDLQTQDIYYFPFNNWLGTKNGDGETERLARVEYKRRFLDESMSMHMLAQTISWFAMFTGGGNRLRDRVSRQDYSVSIIFSLVVVSMISITILKSDNSIISDSKSVSEFTFTIKDIAFGVGFGVLITFLNSLHILLCTKCRSHSEHYYYKKRKREDPEFKDNSGSWPMFMAGMARTIIVFPVLMGLIYISGAGMSLMDDLANSFYIRFLISLILWAVVFEPIKGLIWAFLILKTRKSHKIINKLEEALLRAKPAETFLRNPYGKIEKGLGTEIADVTKLRDTENRKMRDEQLFITIRDMLCFFASLYIMVMLTYYCKDRHGYWYQLEMSTILNINQKNYGDNTFMSIQHADDFWDWARESLATALLASWYDGNPAYGMRAYMNDKVSRSMGIGTIRQVRTKKSAECTMFKQFQGYINDCGEELTSKNEEKTLYMQAGWTELESENGTDASDEYTYKTSEELSTETVSGLLYSYSGGGYTISMSGTQAEIITLFNKLDSERWIDDHTRAVIIEFSAYNAQINYFSVVQLLVEIPKSGIYLPNSWVESVRLIKSEGSDGTVVKYYEMLYIFFSVLIFVKEIVFYLYGRYKVITTMKPTRNPFKIVYQLALGNFSPWNFMDLIVGALAVASVLAYTIRQRTTNRAMEDFNANNGNSYINLTEQRNWEIVFSYCLAGAVFFTSCKMIRILRFNRRIGVLAATLDNALGAIVSFGIAFLFFSMTFNSVLYAVLGNKMGGYRSLMATFQTALAGMLGKLDVTSIQPISQFAFVVIMLYMIAGSKLVLQLYVTIIMFEFEEIRNDSEKQTNDYEIIDHIKYKTKRRLGLLEPKDFAPVSIADTQKDFRLFHSAVAKVNLLHHRATRMLQTQGQYQNQTVINYTLSYDPVSAIHETGPKRFQKWRLNDVEKD