wanglab/gogpt-training-data huggingface dataset:
Protein: Heparan-sulfate 6-O-sulfotransferase (EC 2.8.2.-) (G5EFN7)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Membrane {ECO:0000256|RuleBase:RU364122}; Single-pass type II membrane protein {ECO:0000256|RuleBase:RU364122}.
Interaction partners:
- Heparan sulfate 2-O-sulfotransferase hst-2
- D-glucuronyl C5-epimerase
- Sulfotransferase domain-containing protein
- Sulfotransferase domain-containing protein
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
- GlyPicaN
- Probable syndecan
- Exostosin-1 homolog
- Exostosin-like-3 homolog
- LONg
Sequence:
MKKIGMCSIRGWKGVLGKNLFVFVAILFAASIVYFYIDFPLKVNMRTLEDGFHDDDFYNYEDIVQREDTALRFNKTSNDVIVFVHIQKTAGTTFEKFLVRYQQNLPCKCQAHKKRCNCGRRSSNETWLFSRYSTGWVCGLHADFTELVVNSCVQKVLDKQAGHKKKRNYFYTTFLRNPTDRFISEFRHVQRGATWISSKHVCNGKPASVNDLPTCFDPRIGWEGVSLEEFISCPYNLAFNRQTRMLSNLSLVGCYEHMRKPSYEQDKIMIESAKENLRKMSFFGIKEQMDDSQFYFENTFDMQFTRKMSVWGKSKSNDTVLSESQLAYIRNVNKLDWELYEYAVQLFDERVSQLRRKRRIRR
Protein: Beta-defensin 1 (BD-1) (rBD-1) (Defensin, beta 1) (O89117)
Organism: Rattus norvegicus (Rat)
Function: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P60022}. Membrane {ECO:0000250|UniProtKB:P60022}. Note=Associates with tumor cell membrane-derived microvesicles. {ECO:0000250|UniProtKB:P60022}.
Interaction partners:
- Beta-defensin 4
- Beta-defensin 14
- Bromodomain containing 4
- Bromodomain testis-specific protein
- DEFB24
- Beta-defensin 13
- Beta-defensin 12
- Beta-defensin 5
- Histone H4
- Beta-defensin 15
Sequence:
MKTHYFLLVMLFFLFSQMELGAGILTSLGRRTDQYRCLQNGGFCLRSSCPSHTKLQGTCKPDKPNCCRS
Protein: Uncharacterized protein (Q583D5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSECPRREVGDSWRKDKPLVEGRRSQYTFATNVAPERKSLHYTSSNTCTNSVTAANDNNAGNGGSNNRYFASVSGVIASRSVSAGRMRAPLSSAVRAADGRVSSTNWEDPAGSQTTTSLLTSSSLPSPSLLLPERPISITEAPVRSTTCHPHGNMKDKYVRARSVMAPMQSTPQLGSVTCSSGRRISTSEGVRIPYGADWLTSERISSVQISPRVSSGVTRSSSGIRCVGAANSKLGFATHSPQMRVVNSSRSALSTYARGGDVRDAIPAGRYPSVNPSISTPTRVASARNGESGVAAATLTNDVIHVAAPRATETNNNSNNVNTEVAATAVPDTTLVACSGAQGMVVSDKCMFCTEKFPAPADVSRRLSFDDGCGGAAEPNSSVESRGAAKMLVEVSARLPEHASALASADSRHRKEMSRVIPAPVQLRAGRDAVTATITSTRGVVGGTDNSCTQEAPVAGEVQARCRTLDGRAKSEDLGTRLTDLSHLHSYVGTPVGGSGQRPFIRHSVRGVDSGRAKLAVAPSLAALRDHTLRSALRPGYNLWSGRYSRSVTQVRLGRSHSAGTRLTSSPSENGKPLFNNGSSCYSTRSHVHDNGTAKSSSCKQGEEEEEQESGHAVSVTLTTAGGRLERAARRPIPPASHRNRPCPPADTTAASHSVVPSGRNTINRTSSEPNPPTEDRNSTYLSGPKPTPSNFSGIVHRNINVTASLKGVETVPSFVRRSSGLCPPVEQELGNRLRVESHPVARGAARESGYLCVASVRLARCTSGRIGPQLWDCAHRDDRCPQQRHSFPVAPLQRSATAPPSRQRLLKVEEAGPPVGDAGSVNASTSAASILLRMRSGACQQRVRVQTSHQNSRGDVHTGCGKGTKGESYGVADQPNQQHKFNRGSGSGSGSSACCYGVSDSNTPGEVTERVEKSHGRPEEAERTRPSCSLRGYELHVHRRDETVDKTAGIADDDVQLRDRIINNTHNSSDGMTSHASFERGTKDSRQHVGYNDRIREGYDADSFSDDYYDESDCSDEDSWWFFWHFWSGPAIVVFPPAFVPPLKLDNLRIPNDDLALTRYAIPMPTAVQRSPTRTPSIPPVNVIAPPVVSAFSSSSACSGSRRKRASEIKQAKPLVEGRKEREINIKLLLLEAAERRERRLVHQEEAADRKALQQQWAKKLEY
Protein: Putative DNA (cytosine-5)-methyltransferase CMT1 (EC 2.1.1.37) (Chromomethylase 1) (Protein CHROMOMETHYLASE 1) (O49139)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the CpXpG methylation and in gene silencing.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Protein PAM71, chloroplastic
- Adenosylhomocysteinase 2
- Adenosylhomocysteinase 1
- GDT1-like protein 3
- TRAF-like family protein
- Protein PAM71-homolog, chloroplastic
- Transcriptional activator DEMETER
- DNA
- Probable inactive DNA
- DNA glycosylase/AP lyase ROS1
Sequence:
MAARNKQKKRAEPESDLCFAGKPMSVVESTIRWPHRYQSKKTKLQAPTKKPANKGGKKEDEEIIKQAKCHFDKALVDGVLINLNDDVYVTGLPGKLKFIAKVIELFEADDGVPYCRFRWYYRPEDTLIERFSHLVQPKRVFLSNDENDNPLTCIWSKVNIAKVPLPKITSRIEQRVIPPCDYYYDMKYEVPYLNFTSADDGSDASSSLSSDSALNCFENLHKDEKFLLDLYSGCGAMSTGFCMGASISGVKLITKWSVDINKFACDSLKLNHPETEVRNEAAEDFLALLKEWKRLCEKFSLVSSTEPVESISELEDEEVEENDDIDEASTGAELEPGEFEVEKFLGIMFGDPQGTGEKTLQLMVRWKGYNSSYDTWEPYSGLGNCKEKLKEYVIDGFKSHLLPLPGTVYTVCGGPPCQGISGYNRYRNNEAPLEDQKNQQLLVFLDIIDFLKPNYVLMENVVDLLRFSKGFLARHAVASFVAMNYQTRLGMMAAGSYGLPQLRNRVFLWAAQPSEKLPPYPLPTHEVAKKFNTPKEFKDLQVGRIQMEFLKLDNALTLADAISDLPPVTNYVANDVMDYNDAAPKTEFENFISLKRSETLLPAFGGDPTRRLFDHQPLVLGDDDLERVSYIPKQKGANYRDMPGVLVHNNKAEINPRFRAKLKSGKNVVPAYAISFIKGKSKKPFGRLWGDEIVNTVVTRAEPHNQCVIHPMQNRVLSVRENARLQGFPDCYKLCGTIKEKYIQVGNAVAVPVGVALGYAFGMASQGLTDDEPVIKLPFKYPECMQAKDQI
Protein: Peptidoglycan hydrolase gp36 (Gene product 36) (Gp36) (Q7Y5N4)
Organism: Enterobacteria phage SP6 (Bacteriophage SP6)
Function: Exolysin that catalyzes the cleavage of the host peptidoglycans during virus entry.
Subcellular location: Virion {ECO:0000305}.
Interaction partners:
Sequence:
MAIERQAVQGLRRVQSTGGPSAASFATRQVGVQETSASGSRFLEDLVNAAGSLATVTTSILNQRVEDDKVRQYNRALTGLMPTEDATVGGARAHMLVSLQNDIIAQTMQLSDDAQRFDGDDSQWEDHVINARMAVQDRLWDTYPELRGDKESMRVVTNAFMEQQPKIFAARETAKLKQEAEARIKSMESRILLATRDVPGEAMGDALNQLQKEAMAMQITKQEFDALVSQLAANRAAIGDDSMIQGTKSLKDENGVSLYDRVGQLQTGEIQANRTWAAQNQVALFEKKDAAIKAFEAGQLNREQLLQVMQNHNEISGGTAWSDSEIKSLFDRQAKARATSAKLEDLVARGEHGSPLGLQDISKEDRKAYAGALVDAYTKLANDEITRTGATGEEAEAIRGRYEQMRYAKLGQQLIEDPIIKERYGSLMQLSSANLKDMKIEPEALQTIMRARDSIPEDARRAVMGDKEYAFAENYDLATRMGYTPGQAIEFAQNASRGDKLPGSVMKELNDEVDGVVSDVASGSWLTRGDNMSDMGRDLMLEEANQIARSMKVAGHNNDTIKRHLKSFLQNQYTQLSEGFFTQGVLVKGDVRTLGDTIGANQKDVPTVLRQYLDNHKQALLDASGGMEEGDLYFDVDSKRGMFTIRAGSGRVPVTPAMPLSEIKGQDLLKEHYEKAVKERDEAKKNFEANQMRMWGAGGYQSPAPEKTTAKTVGSRGIADFLMSPAFASGENLPSNFEFNYKRNNMDFYNYVAKTENGANVGFDRVAGVYTPYKDAHGQSVGYGHFLTEEEKKNGYITIGEDKVPFAPGQSQLTPERAMRLLEQDMKSHVPSTKDWAVPFDAMHPGVQRGLMDLSYNLGKDGIKNAPKAYAAFKAGKFTDGFIEMLSTASTEGKRSSGLLVRRAEAYNLAQSGGSVPKISEVETREDGSMYVKFSGSMSEAFVSKSILGKIGKDGWMEVYPPKAGALASGTKVGRIKL
Protein: RNA polymerase-associated protein LEO1 (P38439)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2.
Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:15643076}.
Interaction partners:
- RNA polymerase-associated protein CTR9
- FACT complex subunit SPT16
- RNA polymerase II-associated protein 1
- Cell division control protein 73
- RNA polymerase-associated protein RTF1
- FACT complex subunit POB3
- Transcription elongation factor SPT5
- Transcription elongation factor SPT4
- Transcription elongation factor SPT6
- Antiviral protein SKI8
Sequence:
MSSESPQDQPQKEQISNNVGVTTNSTSNEETSRSQDDNVKEVNGNDDTKEEEQEEDAELDDLFGDDNDDDDDDDVKKSETEKSDSDSDEDDEGENINHRSRHRESLGLDDDEAEEQAMYTRKFYGEDANNFSDQDETTHTFKEENVELVRHIIPSKANVNETASHNEIFYARIPNFLTIDPIPFDPPSFEAKVNERASNSASREDQLDDRLIDENTVRWRYSRDKDQHVFKESNTQIVQWSDGTYSLKVGEECTDILVNDTSNTFLTVSHDQQELIQCYEGGEIKKTLMFIPTSTNSKIHQKLSKAVIRRNQRQSKGPGTYIVSMDPEVEKKELERKQSQILRDRRRRQLKEKEKQESPDAAFETGFRKQNSPTTYGASRRNEYEEDDFLVDDDEEEEAAFDDEEDDNEEEEEEEDADEENASRLRNLKREGAAMYREEEEEEKDRSETKRRRVAVIEDDEDED
Protein: Major capsid protein (Q8V9P2)
Organism: Sulfolobus islandicus rod-shaped virus 2 (SIRV2) (Sulfolobus virus SIRV-2)
Function: Self-assembles to form a helical, filamentous nucleocapsid. The capsid proteins wrap around the DNA and maintain it in an A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues (Probable). This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).
Subcellular location: Virion {ECO:0000269|PubMed:25999507}.
Interaction partners:
Sequence:
MAKGHTSRSYSQRYAKWQAKFNAFSNPTVASTILSNVSPVAQQNFQTNVPKFTSVNENVSAVLTQYGITGPNRAIYQGFGLKVARALNRIGSGPALVNMINGLKGYYISAFNANPQVLDAVVNIITGSPTGYVS
Protein: Broad-complex core protein isoform 6 (Q24206)
Organism: Drosophila melanogaster (Fruit fly)
Function: Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis.
Subcellular location: Nucleus.
Interaction partners:
- ETS-like protein pointed
- Ecdysone receptor
Sequence:
MDDTQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQNLANSGGRTPLNTHTQSLPHPHHGSLHDDGGSSTLFSRQGAGSPPPTAVPSLPSHINNQLLKRMAMMHRSSAAAAAEETSHAFKRLRGSDNSLPLSGAVGSGSNNNSPDLPPLHARSASPQQTPADFSTIKHHNNNNTPPLKEEKRNGPTGNGNSGNGNGNGNGASNGNGISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNANANDEHSNDSTGEHDANRSSSGDGGKGSLSSGNDEEIGDGLASHHAAPQFIMSPAENKMFHAAAFNFPNIDPSALLGLNTQLQQSGDLAVSPQGGSTGSLLSGVIVPGGSGGTPSNSSSNNNNNNSNNQQQKVEQQSSPHQLLQQQHHSTPHTNSPQLKQEQPKSGGGSCKSSDLHIAAGSERSLSRSSQGMPDAGGHSATPSPTAAYHKRERERERERERERERERERSLDHERDLERPGGTGSPPPPPPSHHSHFGQHPLSLLPSHHQLHATHHELSAAAAHHAHAHAHAAHAHALARAGSPMEHHHLLHHRRASLSPSGAVSSASGAGGRGGGAGGPGGPGGSLLSSVRAQDVAQANRLLLPLPLNACHRCDVCGKLLSTKLTLKRHKEQQHLQPLNNAVCNLCHKVFRTLNSLNNHKSIYHRRQKNHHSYFHHGAGVSQAGSPGSRLHQSLSSLSAAAAAANNSVNVGGGSVGGAGGNAVAAAAAAAAAAAELLLSPIVGAAAVAGGTASSTLQLAAAHQQQQQQSSPGIVKPCMDFL
Protein: Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein (Q725S5)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
- Pyruvate:ferredoxin oxidoreductase
- Iron-sulfur cluster-binding protein
- Pyruvate ferredoxin/flavodoxin oxidoreductase family protein
- Pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit, putative
- Pyruvate ferredoxin oxidoreductase, gamma subunit, putative
- Pyruvate ferredoxin oxidoreductase, beta subunit, putative
- Pyruvate ferredoxin oxidoreductase, beta subunit
- L-lactate dehydrogenase
- Pyruvate ferredoxin oxidoreductase, alpha subunit
- Pyruvate ferredoxin oxidoreductase, iron-sulfur binding subunit, putative
Sequence:
MSSEKTERIFIKGNEAIAHGALAAGCRCYFGYPITPQNDIPEMMSSAIPAAGGEFVQAESEVAAANMLLGAAACGVRAFTSSSSPGVSLMQEAISYMAGSELPGVIVNMNRGGPGLGDIGPSQGDYFQSVKGGGHGDYRTYVLAPATCQECYDMMFEAFDVAYRFRTPVLVLGDAIVGQMKEPVTPWKRDDLDPATEGADWRLQGAKGRPARLLKSLFLEDGALAGQNRNLQAKYEAMKELARAECFETEDADLVVVAFGSIGRIAKSAIRKLRAQGHKVGLVRPVTLFPFPEKVLQDLAAKGKRFLTIEHNCGQMVDDVRLAVRAYCDSDFYGHMPGELPGSDDFLKPILDALGRK
Protein: Calcium-binding protein PBP1 (KIC-related protein 2) (PINOID-binding protein 1) (Q9LSQ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor that binds calcium in vitro.
Interaction partners:
- DNA repair protein RAD4
- Transcription and mRNA export factor ENY2
- Calmodulin-like protein 12
- Enhanced ethylene response protein 5
- SAC3 family protein C
- SAC3 family protein B
- Protein ALP1-like
- Auxin canalization protein
Sequence:
MASPKSSTRPNQENQEPQFQDFFPTMAGKLGGEGLIEEICKGFELLMDKDKGVITFESLRRNASTVLGLGDLTDDDVRYMINEGDFDRDGALNQMEFCVLMFRLSPELMEASRCVVTEVIEEEFYRH
Protein: Vomeronasal type-1 receptor (Q3KNW7)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU364061}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU364061}.
Interaction partners:
Sequence:
MWVIISTVATSKSTNVGLVYSLIYCKTRLFIYYHAMIFQSAMFTQGFLFLFLMIWTSFYMVTIFLRHQKTVFHIHSISLSPQSFPETEASHVFFLLVSRFVFFYGTNVCLSTYISSMYENSLILENITSFVSSSYPIICTLILINYDNKVSRLTCAILNMIISPCLPHSFLLHQRNPDKNYFNHKRMCF
Protein: Protocadherin alpha-C2 (PCDH-alpha-C2) (Q9Y5I4)
Organism: Homo sapiens (Human)
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MEQAGTRPAATEHPRLRRPMPWLLLLPLLLLLLLLLPGPAASQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVDRVSKILPDTQRHVKSPRTYSEITLYLIIALSTVSFIFLLTIIILSIIKCYRYTAYGTACCGGFCGVRERSPAELYKQANNNIDARIPHGLKVQPHFIEVRGNGSLTKTYCYKACLTAGSGSDTFMFYNTGAQTGPGPSGAQAAVTDSRNLTGQSGQNAGNLIILKNEAVSQNEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Protein: TRAF family member associated NFKB activator (E7EW82)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKQTENYEQRIREQQEQLSLQQTIIDKLKSQLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGIAREKLPKVRRQEVSSPRKETSARSLGSPLLHERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTATAHLEALS
Protein: Chaperonin GroEL (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin-60) (Cpn60) (A0A0H3LCC3)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Subcellular location: Cell surface {ECO:0000256|ARBA:ARBA00004241}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00600}. Secreted, capsule {ECO:0000256|ARBA:ARBA00025702}. Secreted, cell wall {ECO:0000256|ARBA:ARBA00004191}.
Interaction partners:
Sequence:
MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF
Protein: SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) (O60239)
Organism: Homo sapiens (Human)
Function: Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:30217979}; Peripheral membrane protein {ECO:0000269|PubMed:30217979}. Mitochondrion {ECO:0000269|PubMed:12167088}. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes. {ECO:0000269|PubMed:30217979}.
Interaction partners:
- Ras-related protein Rab-11A
- Tyrosine-protein kinase BTK
- Ubiquitin carboxyl-terminal hydrolase 10
- Ras GTPase-activating protein-binding protein 1
- Ras-related protein Rab-11B
- Poly [ADP-ribose] polymerase tankyrase-1
Sequence:
MDAALKRSRSEEPAEILPPARDEEEEEEEGMEQGLEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELVKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMALKNLEMISDEIHERRRSSAMGPRGCGVGAEGSSTSVEDLPGSKPEPDAISVASEAFEDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMFPVLGPRSECSGASSPECEVERGDRAEGAENKTSDKANNNRGLSSSSGSGGSSKSQSSTSPEGQALENRMKQLSLQCSKGRDGIIADIKMVQIG
Protein: Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) (Q55BZ4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway.
Interaction partners:
- Probable ethanolamine kinase B
- Probable ethanolamine kinase A
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 3
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 2
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 1
- Sphingosine-1-phosphate lyase
Sequence:
MSTTTNKKPIRVYVDGCFDLMHFGHANALRQARELGDILVVGVHTDEEIAKNKGPPVMNEQERYKAVRACKWADEVAEGAPYTLTEEYLDSLNCDFCVHGEDISVGADGKDVYEGIKKSGKFRFIKRTEGVSTTELVGRMLLCTKDHLQNVSGEQTSPLGGVNPNVLHKQSPYTSLSHFLPTTRKIVQFSEGRSPKPNDKIIYMDGGFDLFHVGHTEALKQARALGDYLIVGVHDDRVVHEQKGSNFPIMNLHERVLSVLSCRYVDEVVIGAPFSVTKDMIDSLHINVVVHGDDQVVLGPEGGVDPYKLPRELGIYKEVKHTEGLTATEIVKRIIDNRLQYEARNRKKEAKEINFIEQSN
Protein: Pectinesterase inhibitor 8 (Pectin methylesterase inhibitor 8) (OsPMEI8) (Q6ETW4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Pectin methylesterase (PME) inhibitor that inhibits PME in vitro.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000269|PubMed:26874295}.
Interaction partners:
- Small ribosomal subunit protein uS9
- 40S ribosomal protein S29, putative, expressed
- Os10g0411700 protein
- Small ribosomal subunit protein eS19
- Os01g0220300 protein
- 40S ribosomal protein S30
- 40S ribosomal protein S15, putative, expressed
- Small ribosomal subunit protein uS19
- Os03g0796501 protein.
- 40S ribosomal protein S6
Sequence:
MAQRASRRPAAAAAAVVVAVVLAVSGGVGATPETACRAAAEEDRRVDYEFCVSRLSHHHDSPDADTWGLAKVAADVGVCIAGDAAYDAKAKLQAAKAGGEREALERCAELYDRMGSAFAAAYDDINRREYAAGKEKAGEAASLARRCDGAFADAGVAPSPLERQTAESVKIAIVCTAITNLVK
Protein: Defective in cullin neddylation protein 1 (Q12395)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes.
Interaction partners:
- NEDD8-conjugating enzyme UBC12
- Cell division control protein 53
- RING-box protein HRT1
- NEDD8-activating enzyme E1 catalytic subunit
- Cullin-3
- COP9 signalosome complex subunit 5
- Cullin-associated NEDD8-dissociated protein 1 homolog
- Putative uncharacterized protein YLR124W
- Cullin-8
- NEDD8-like protein RUB1
Sequence:
MSNNKIKRKDASPEQEAIESFTSLTKCDPKVSRKYLQRNHWNINYALNDYYDKEIGTFTDEVSTVAHPPVYPKELTQVFEHYINNNLFDIDSLVKFIEELGYNLEDLATLCLAHLLGYKKLEEPLKREDFLSTWFMQGCSTISDMQECIKTLDVKLHEDLQYFTQIYNYAFNLILDPNRKDIDTDEGIQYWKLFFQPEYPVRMEPDLLEAWFRFLRDEGKTTISKDTWRMLLLFFKRYPTIQKIISDYDETAAWPFIIDEFYECLQDQQ
Protein: Cardiotrophin-1 (CT-1) (Q60753)
Organism: Mus musculus (Mouse)
Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
Subcellular location: Secreted.
Interaction partners:
- Leukemia inhibitory factor receptor
- Interleukin-6 receptor subunit beta
- Ciliary neurotrophic factor receptor subunit alpha
- Leukemia inhibitory factor
- Cardiotrophin-2
- Oncostatin-M-specific receptor subunit beta
- Oncostatin-M
- Interleukin-6 receptor subunit alpha
- Ciliary neurotrophic factor
- Interleukin-27 receptor subunit alpha
Sequence:
MSQREGSLEDHQTDSSISFLPHLEAKIRQTHNLARLLTKYAEQLLEEYVQQQGEPFGLPGFSPPRLPLAGLSGPAPSHAGLPVSERLRQDAAALSVLPALLDAVRRRQAELNPRAPRLLRSLEDAARQVRALGAAVETVLAALGAAARGPGPEPVTVATLFTANSTAGIFSAKVLGFHVCGLYGEWVSRTEGDLGQLVPGGVA
Protein: DNA repair protein RAD34 (Q06665)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in nucleotide excision repair (NER) of damaged ribosomal DNA (rDNA). Required for the repair of the RNA polymerase I-transcribed strand of rDNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- DNA repair protein RAD33
- UV excision repair protein RAD23
- Cell division control protein 31
- General transcription and DNA repair factor IIH subunit TFB1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- DNA repair protein RAD14
- DNA repair protein RAD10
- DNA repair protein RAD2
- DNA repair protein RAD7
- Radiation-sensitive protein 28
Sequence:
MAKRLLESSQNDQANRKNSKIEKKEVSFYEEEETDDSFDSFYQDEEDDLSDIDWEEVSLDGSLTVTFGNIRRDREKVSKYKRKHNKKAFNYQRLKYGLHLIMIPFMLFLLKSRMKWIDDERLNRRLRRSVPKLIGKKFKDWDVRDPAFKMDSLRTLLLGLVLWFRSNYKMNSNGIRQNFNRLQYLIKYADNQNENSISESTYKKVLENQQEFYGNRPLINHGVEDIRKMAKRKMANRDILTLFFFIILENVLPGPKKLYLCFALPLHDYDIRCNKVKWQIEHGIGKVPNRFDSDLIQPYFWIELEVPTLSDGELYIIDPIAHLGEREMVLKTREDQFVPTYQPSVDMKYNLNQKFHYVVRINHAEKVLQDVSPRYVPNVCYRYFELSESSPILKSKHYTSYQYLSKWLKVLNKKKASVHHYAIMKKIALTNFTLPKSVTEIKRTDNFVIPSLLKSNEVLKACAKQAATFTKGDNSQEPIFWRRDVIQLKSKQHWAILGRSILPNAQPLKRKKYLPMRERMVRNLDKYVIKELFSYEQTMKSPKYPSTYCDHLGQEHVITDLSHYKNKFGNIEIYSKETKPDGFELIPLSKEVDIKCLIKEYNKGKRKMQKIKYLDVVSGFDFKQKKGHAIPKIESILVKETDYKAVQLLKQQTKVLLGLSFWDILLRKLRVNDRLNAEYGNVGNNEETLDDH
Protein: Sodium/hydrogen exchanger (A4GWV2)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004520}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004195}.
Interaction partners:
Sequence:
MACRTCLWLLGTTFFTCTVRLVVEGTEVGATQGSQPEPGVVGSNHSQAGGGHGSSISGIQIVTFKWHHVEAPYLIALWILVAGVSKMVVELNHSLTSVIPESALLILIGWILGGIIYGADKMQTFTLTPTVFFFYLLPQVILDAGYFMPNKLFFSNMGAILVYAVIGTCWNAATVGLGLWGCWLGGAMGDIDIGLLQFLLFGSLIAAVDPVAVIAVFEEVHVNEVLFIMVFGESLLNDGVTVVLFNVFDAFVSLGGAEIDAVEIIKGIISFFVVAFGGSLVGIIFALLISLLTRCTKNIQIIEPGFIFILGYLSYLTAEMLSLSAILSIVFCGICSQKYINANMDERSVTTVRYVMKVFANGSETIIFVFLGISAIDPAVWVWNTGFILLTLLFIFVFRFIGVFLLTWILNKYRLVPLEFIDQVVMSYGGLRGAVAYGLVAMPGENKFKEKNLMVSTTLIVVYFTVMLQGITMKPLVTWLKVKRAAVTELTLAEKIQNRTFDHMLVAIEDISGQIGHNYMRDKWHNFEERWLCWFLMKPSARKSRDYIFNIFHQLNLKDAMSYVKEGERRGSLAFVRNETKADVDFNKKFRASFSEIMPDIMADNMGPDHVPLSSILQDIVPSVCLVMHEQDLTMRESEDFNAHHLLQQHLYRGRKQHRHRYSRSHLETNRDENEVQEIFQRTMRSRLESFKSAKMGVAPAKKIQTKHQKKDKPQKVRGEGTFSPFLRVRPHSHPLIGNVMCMLCNFMLCHF
Protein: G-protein coupled receptor 6 (Sphingosine 1-phosphate receptor GPR6) (Q6YNI2)
Organism: Mus musculus (Mouse)
Function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).
Subcellular location: Cell membrane {ECO:0000305|PubMed:17284443}; Multi-pass membrane protein {ECO:0000305|PubMed:17284443}. Note=Highly expressed and localized along the cytoplasmic membrane as well as in a perinuclear compartment.
Interaction partners:
- G protein-coupled receptor 88
Sequence:
MNASAAALNESQVVAVAAEGAAAAATAAGAPDTGEWGPPAASAALGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYVVPSETVSLLMVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLADRTSCSVVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLFCGCFQSKVPFRSRSPSEV