wanglab/gogpt-training-data huggingface dataset:
Protein: Ornithine decarboxylase antizyme 1 (AZ1) (ODC-Az) (P54368)
Organism: Homo sapiens (Human)
Function: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Interaction partners:
- Antizyme inhibitor 1
- Ornithine decarboxylase
- Antizyme inhibitor 2
- Large ribosomal subunit protein eL27
- Polyubiquitin-B
- Large ribosomal subunit protein eL19
- Elongation factor 1-gamma
Sequence:
MVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSESSRVSLHCCSNPGPGPRWCSDAPHPPLKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAEEQLRADHVFICFHKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEEE
Protein: 60S ribosomal protein L10, putative (Q38EC5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 40S ribosomal protein S8
- 40S ribosomal protein S16, putative
- 40S ribosomal protein S26
- Small ribosomal subunit protein uS5
- 60S ribosomal protein L29
- 60S ribosomal protein L19, putative
- Uncharacterized protein
- 60S ribosomal protein L39, putative
- 60S ribosomal protein L5, putative
- Large ribosomal subunit protein eL18
Sequence:
MARRPARCYRFCKNKPYPKSRFCRGVPDPRIRTFDIGKRRAPVDEFPVCVHVVSRELEQISSEALEAARIQANKYMVKRANKECFHMRIRAHPFHVLRINKMLSCAGADRLQTGMRQSYGKPNGTCARVRIGQILLSMRTKDTYVPQALESLRRAKMKFPGRQIIVISKYWGFTNILRNEYEELRDAGKLQQRGLHVKLITPKGKITPYNIMA
Protein: Insulin-like growth factor 1 (Insulin-like growth factor I) (Somatomedin) (F2X2F3)
Organism: Bos taurus (Bovine)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU000406}.
Interaction partners:
Sequence:
MVTPTQVKMPITSSSHLFYLALCLLAFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKAQKYQPPSTNKKMKSQRRRKGGPKKRPGGEQKEGTEASQQMQGKMKEQRRETGARN
Protein: RE54443p (Q7YU56)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MASSATNVDGGSGTSTALPSLFPAVGAAAGVKDMDGLMAINDSALSQQIEFILQDAPMEQDDDPHQHTHVHHHHHSQHHPHSHSHQQQQQQHLQQQQQQQQHHHPHHHLKLDNSSNNHPPTAAAAAAAVAVAATTAATAAAATNNSASFSSNSSSSNSNNSNHLDNQQQLLIQQQQQQQQHHLLNGRRIIIQATGNSSVLAASDIKEEDEEEEDPELNDENLQDIEEEAQAAEADEEPETTAHLSTQVKLELEEDDEMPDEEEEEDEDDDEELQHGQLEYQISAATQTAGAATSSAAGGAATAGGGSQQLVQLPAGSIVSTTTHRLSVPVTEAALVQLQRRPVYISNAVGGLTAGATYVRMPAAAVISRSPMTVLNVVQQALPATQLILQTQQQQTPAAAAAEQQLALALEQQRQQQEQQAQQQRQQQQQQEQQRQQQQQQQQQQQQQAQQEQQRQQQQQLQQQQQQQQTHPVKHSASGSSSTNNNSTTNSTNSNNNTPAATATVTTSYQCVECVEKFDSKELFDIHRSGHANNMKCAICNMVLKSLKNYEKHCLRCKPYECQICGRVVRFRPNFIKHMRVHTGQQSERHKYKCEVCHKEFMSFEYFKVHKKIHNENVNLTCEICGKVFSALASLRGHSKLHSGVKLHKCDVCGKGFGQRYNLKIHARTHTGDFPFECKICKKKLHTQSSLQTHMQVHLRDQPGAAAAAATAAGAASSKASNSSNSSNSSNSSSSNSSSNGVSAAVSAATTTTTIVKLEPPHEIERPGTSSNQQLQQSQHHQMELDDQSGLSGDEEDGSGGGMNSSSHIVNATTNRLTTGEDSSESSNASLHLNQHSSTSSSPASQHQVSSHQQHVHQQQQQQQQSQQQYLVSAPTRTIVIKNYMQQGSQQQQQQQQQQQHTSDPTPVLHAQVIQSGAGTSNGSGNTSSTNSSSNSSTNIVTTNAGGNLSNGSQLIRKTPIIHHSTGSSNGSGGSALTSVVQQTGVISPAQSPSSSSTSCSSSTVLVSKATGVPLSIASSAAAALGGSTIIRSTRNHQQQQQQQQPAQQQQQQQRVTQRNNHRNHHRRRHLADIDDDEDDDEDQPQQQTHTQQTQQHHHHHSHHHNHHNHHFDDDDDDEKSSPSLATAAIIKVEPNLYSSGSGDNSNDMFIKEEVMFEDSAALHSPQSPPSSKFRISNFDSDLVDHHVDLNHSLPPYGNLFEPRSIPDSIPVQLYPDDDDDFRLDHSSLGGLHNTTSSSTTDGDFIKKEWVYGTGASSYAMNGKFDDDSDALCDAANFIYN
Protein: Protein-glutamine gamma-glutamyltransferase 5 (EC 2.3.2.13) (Transglutaminase X) (TG(X)) (TGX) (TGase X) (Transglutaminase-5) (TGase-5) (O43548)
Organism: Homo sapiens (Human)
Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15290349}. Note=Associated with intermediate filaments.
Interaction partners:
- Protein-glutamine gamma-glutamyltransferase K
- Corneodesmosin
Sequence:
MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL
Protein: Nuclear transcription factor Y subunit C-2 (OsNF-YC2) (Transcriptional activator HAP5C) (OsHAP5C) (A6BLW4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcription factor involved in the regulation of flowering time under long day (LD) conditions. Functions as repressor of flowering, independently of HD1 and GHD7. Controls flowering time by negatively regulating the expression of EHD1 and HD3A. Component of the NF-Y/HAP transcription factor complex (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:26542958}. Cytoplasm {ECO:0000269|PubMed:26542958}.
Interaction partners:
- Nuclear transcription factor Y subunit B-10
- Nuclear transcription factor Y subunit B-8
- Nuclear transcription factor Y subunit B-3
- Os09g0568200 protein
- Nuclear transcription factor Y subunit B-11
- Nuclear transcription factor Y subunit B-2
- Nuclear transcription factor Y subunit B-4
- HAP3 subunit of HAP complex
- HAP3 subunit of HAP complex
- HAP3 subunit of HAP complex
Sequence:
MDNQQLPYAGQPAAAGAGAPVPGVPGAGGPPAVPHHHLLQQQQAQLQAFWAYQRQEAERASASDFKNHQLPLARIKKIMKADEDVRMISAEAPVLFAKACELFILELTIRSWLHAEENKRRTLQRNDVAAAIARTDVFDFLVDIVPREEAKEEPGSALGFAAGGPAGAVGAAGPAAGLPYYYPPMGQPAPMMPAWHVPAWDPAWQQGAAPDVDQGAAGSFSEEGQQGFAGHGGAAASFPPAPPSSE
Protein: Carnocyclin-A (B2MVM5)
Organism: Carnobacterium maltaromaticum (Carnobacterium piscicola)
Function: Cyclopeptide antibiotic that inhibits the growth of Gram-positive bacteria, but has no effect on the growth of Gram-negative bacteria.
Subcellular location: Secreted {ECO:0000269|PubMed:18552180}.
Interaction partners:
Sequence:
MLYELVAYGIAQGTAEKVVSLINAGLTVGSIISILGGVTVGLSGVFTAVKAAIAKQGIKKAIQL
Protein: Phosphate acetyltransferase (EC 2.3.1.8) (Phosphotransacetylase) (P9WHP1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in acetate metabolism.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Acetate kinase
- 2-oxoglutarate oxidoreductase subunit KorA
- Malate synthase G
- Bifunctional protein GlmU
- Acetyl-coenzyme A synthetase
- 2-oxoglutarate oxidoreductase subunit KorB
- Dihydrolipoyllysine-residue acyltransferase component of branched-chain alpha-ketoacid dehydrogenase complex
- Propanal dehydrogenase
- Biotinylated protein TB7.3
- Putative acyltransferase Rv0859
Sequence:
MADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITRLSAERDYILELLLAHTSAGLPYERCVGVTYQQLHADRDDAIAEIVDSYHAMADECDAVVVVGSDYTDVTSPTELSVNGRIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQRAHTAAVVANRCELSAIPAVTDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVSGDVALREREVMGVLAAGMTADHVLERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSLSCIVLNGGFQLHPAIAALVSGLRLRLPVIATALGTYDTASAAASARGLVTATSQRKIDTALELMDRHVDVAGLLAQLTIPIPTVTTPQMFTYRLLQQARSDLMRIVLPEGDDDRILKSAGRLLQRGIVDLTILGDEAKVRLRAAELGVDLDGATVIEPCASELHDQFADQYAQLRKAKGITVEHAREIMNDATYFGTMLVHNCHADGMVSGAAHTTAHTVRPALEIIKTVPGISTVSSIFLMCLPDRVLAYGDCAIIPNPTVEQLADIAICSARTAAQFGIEPRVAMLSYSTGDSGKGADVDKVRAATELVRAREPQLPVEGPIQYDAAVEPSVAATKLRDSPVAGRATVLIFPDLNTGNNTYKAVQRSAGAIAIGPVLQGLRKPVNDLSRGALVDDIVNTVAITAIQAQGVHE
Protein: GTPase activating protein (SH3 domain) binding protein 1 (Ras GTPase-activating protein-binding protein 1) (Q7ZVG3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, Stress granule {ECO:0000256|ARBA:ARBA00004210}.
Interaction partners:
Sequence:
MVMEKPSAQLVGREFVRQYYTLLNQAPDYLHRFYGKNSSYVHGGLDNNGKPAEAVYGQSEIHKKVMALSFRDCHTKIRHVDAHATLNEGVVVQVLGGLSNNMQPMRKFMQTFVLAPEGTVANKFYVHNDIFRYQDEVFGDSDSEPPEESEEDVEELERVHSPEVVQEESSGYYEQTPCVEPEVPQEEVSVTPEPQPEPEVEVEPEPAAVELKAEPISQPEVHVEEKTQRSPPSPTPADTAPTMPEDNRPSSWASVTSKNLPPGGVVPATGVPPHVVRVPSAQPRVEVKTETQTTAQRPQRDQRPRDQRPGPSPAHRTPRPGVVREGESGESEVRRTVRYPDSHQLFVGNVPHDVDKNELKEFFEQYGTVLELRINSGGKLPNFGFVVFDDSEPVQKILNNRPIKLRGDVRLNVEEKKTRSAREGDRRDIRPRGPGGPRDRIGGSRGPPTRGGMAQKPSFGAGRGTGPSEGRYTGPRQ
Protein: Integral membrane protein DGCR2/IDD (Seizure-related membrane-bound adhesion protein) (P98154)
Organism: Mus musculus (Mouse)
Function: Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Splicing factor ESS-2 homolog
- Palmitoyltransferase ZDHHC8
- Proline dehydrogenase 1, mitochondrial
Sequence:
MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACHGGTIQCIPLPWQCDGWPTCEDKSDEADCPVTGEARPYGKETVDLRQGRARGGDPTHFHTVNVAQPVRFSSFLGKCPSGWHHYEGTASCYRVYLSGENYWDAAQTCQRVNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNHSLEGRWEVAFKGSPEVFLPPDPIFASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCSEKSSFLCKRSQTCVDIKDNVVDEGFYFTPKGDDPCLSCTCHRGEPEMCVAALCERPQGCQQYRKDPKECCKFMCLDPDGSSLFDSMASGMRLVVSCISSFLILSLLLFMVHRLAQRRRERIESLIGANLHHFNLGRRIPGFDYGPDGFGTGLTPLHLSDDGEGGTFHFHDPPPPYTAYKYPDMDQPDDPPPPYEASINPDSVFYDPADDDAFEPVEASLPAPRDGGIEGALPRHLDQPLPPAETSLADLEDSTDSSSALLVPPDPAQSGSTPATEAPPGGGRLPRASLNTVV
Protein: Holocarboxylase synthetase (A0A8I6AAD0)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEDRLQMDNGLIAQKIVSVHLKDPALKELSKASNKQVQAPLPSPEASLEAQPAQGVMEQAGQGDWKAAGEGPSPQRRGCAPVSESAADGDPGQGSTELCQLHLSSCHECLELENSTIESVRCASAENIPDLPHDCSSSVEGTAGELCPERKGKRVNISGKAPNILLYVGSGSEEALGQLQQVRSVLTDCVDTDSYTLYHLLEDSALRDPWPDNCLLLVIASRDPIPKGIHHRFMAYLSQGGKVLGLSSSFTFGDLRVARRDVLRNTAQNLVFSKADGSEVRLSVLSSGYVYEEGPSLGRLQGHLENEDKDKMIVHVPFGTHGGEAILCQVHLELPPSAPLVQTTDDFNVLKSSNTRRLEVLKEILTALGLSCDAPQAPALTPLYLLLAAEEIQGPFMQWLARHVDPEGVIKSSKLSLKFVSSYTSEAEITPSSIPVVTDPEGFSSEHFNLETYRQNLQSTRLGRVILFAEVTSTTMSLLDGLMFEMPQEMGLIAIAVRQTQGKGRGPNAWLSPVGCALSTLLVSIPLRSQLGQRIPFVQHLMSLAVVEAVRSIPEYEDINLRVKWPNDIYYSDLMKIGGVLVNSTLVGETFYILIGCGFNVTNSNPTICINDLIEEHNKQNKAGLKPLQADCLIARAVTVLEKLIDRFQDQGPDGVLPLYYKYWAHRSPHRLSQLSPPCVVKSFPF
Protein: 4-hydroxycoumarin synthase 1 (EC 2.3.1.208) (Biphenyl synthase 2) (SaBIS2) (D2DRC4)
Organism: Sorbus aucuparia (European mountain ash) (Rowan)
Function: Type III polyketide synthase involved preferentially in the biosynthesis of 4-hydroxycoumarin from salicoyl-CoA. Can also use benzoyl-CoA and malonyl-CoA to produce 3,5-dihydroxybiphenyl as a major product and benzoyldiacetic acid lactone as a minor side product. Can also use m-hydroxybenzoyl-CoA as substrate, producing m-hydroxybenzoyl diacetic acid lactone as a derailment product. No activity with p-hydroxybenzoyl-CoA, CoA-linked cinnamic acids or acetyl-CoA.
Interaction partners:
Sequence:
MAPSVKDQVEPQHAKILAIGTANPPNVYYQEDYPDFLFRVTKNEHRTDLREKFDRICEKSRTRKRYLYLTEEILKANPCIYTYGAPSLDVRQDMLNPEVPKLGQEAALKAIKEWGQPISKITHLIFCTASCVDMPGADFQLVKLLGLNPSVTRTMIYEAGCYAGATVLRLAKDFAENNEGARVLVVCAEITTVFFHGLTDTHLDILVGQALFADGASAVIVGANPEPEIESPLFEIVACRQTIIPNSEHGVVANIREMGFNYYLSGEVPKFVGGNVVDFLTKTFEKVDGKNKDWNSLFFSVHPGGPAIVDQVEEQLGLKEGKLRATRHVLSEYGNMGAPSVHFILDEMRKKSIEEGKATTGEGLEWGVVIGIGPGLTVETAVLRSEFITC
Protein: Kruppel-like factor 2 (O62259)
Organism: Caenorhabditis elegans
Function: Probable transcription factor which regulates lipid metabolism.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- non-specific serine/threonine protein kinase
- CCM gene homolog
- Programmed cell death protein 10 homolog
- Protein drl-1
- Calponin-homology
- Transcription factor sox-2
- Serine/threonine-protein kinase smg-1
Sequence:
MYSSIVPSSSNGYYHQSQYQNAHHQHHQQHYHQQSHHHYNGAAAAPVINVHNYHFHTGPVNNQVIEQHYNHHNHVQQTFEENIPQGPHSSFNFSHDFPQQNNSETHLNHMEPSMTPMEHQNSGSSTPYPFEAKLFVPSPAASVSSYSFSSDLSGKDEEDPRIPLKDRGRVYHPQSTEKPKKVPSKRRDKATLDRLRVHKCFYQGCGKVYTKSSHLTAHERVHSGEKPYPCEWPGCSWRFARSDELTRHYRKHTGAKPFACKECSRKFSRSDHLQLHMKRHETDEQDDGMDDFKDFMTFI
Protein: Mitochondrial intermediate peptidase (MIP) (EC 3.4.24.59) (Q99797)
Organism: Homo sapiens (Human)
Function: Cleaves proteins, imported into the mitochondrion, to their mature size.
Subcellular location: Mitochondrion matrix.
Interaction partners:
- HBS1-like protein
- Hemoglobin subunit gamma-2
- Hemoglobin subunit gamma 1
- Frataxin, mitochondrial
- Xaa-Pro aminopeptidase 3
- Tumor necrosis factor receptor superfamily member 19
Sequence:
MLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFGERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQNSEVMPWDPPYYSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSSPTLLTPSMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVNQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILKETQEKFYGLPYVPNTAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRAAGERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE
Protein: E3 ubiquitin-protein ligase SINA-like 4 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SINA-like 4) (Seven in absentia-like protein 4) (Q9C9M0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Interaction partners:
Sequence:
MTKLGRRNDGGGKSHRSSTKRQRRTSVSVDDPSPGEEEEKTLVVLTDDSDSEEDDKPLGDVLRTCRKRRVSSPKSVTLPNSNVLECPNCFDPLKKPIFQCNNGHLACFLCCIKLKKRCSFCKLPIGDVRCRAMEKVIKAGLVSCSNAIYGCKQSTTYGNQLQSHEKVCVFAPCSCPIKDCNYIGFYKDLINHFRATHKVSPGDINSFVFDRPVIFGLDLDSSDKMVIFVEEKQGNLFVVQGFIGSHGVYATVSHIAPMVPEVRKFSCSLARLRPYSTLRLGLEVKNIQKLRSQEEQPQEDFLLIPSYMVNGDHMKMEISIGDKNDYTHI
Protein: Sodium-dependent phosphate transport protein 4 (Na(+)/PI cotransporter 4) (NPT4) (Sodium/phosphate cotransporter 4) (Solute carrier family 17 member 3) (O00476)
Organism: Homo sapiens (Human)
Function: Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule. In particular, participates in the secretion of urate from the cell into the lumen. Urate is the end product of purine metabolism. May have roles in the metabolism and secretion of estrone sulfate, estradiol-17-beta-glucuronide, ochratoxin A, as wells as drugs such as bumetanide.
Subcellular location: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15505377}; Multi-pass membrane protein {ECO:0000269|PubMed:15505377}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:20810651}; Multi-pass membrane protein {ECO:0000269|PubMed:20810651}.
Interaction partners:
- Solute carrier family 22 member 12
- Solute carrier family 2, facilitated glucose transporter member 9
- Solute carrier family 22 member 11
- Glucose-6-phosphate exchanger SLC37A4
- Solute carrier family 22 member 6
- Solute carrier family 22 member 13
- Sodium-dependent phosphate transport protein 2A
- Monocarboxylate transporter 9
- Organic anion transporter 3
Sequence:
MATKTELSPTARESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPKSLPAKSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL
Protein: Modulator of FtsH protease HflK (P0ABC7)
Organism: Escherichia coli (strain K12)
Function: HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:8947034}; Single-pass type II membrane protein {ECO:0000269|PubMed:8947034}.
Interaction partners:
- Modulator of FtsH protease HflC
- ATP-dependent zinc metalloprotease FtsH
- GTPase HflX
- tRNA dimethylallyltransferase
- RNA-binding protein Hfq
- Uncharacterized protein YjeT
- High frequency lysogenization protein HflD
- N-acetylmuramoyl-L-alanine amidase AmiB
- Membrane protein insertase YidC
- Bifunctional NAD
Sequence:
MAWNQPGNNGQDRDPWGSSKPGGNSEGNGNKGGRDQGPPDLDDIFRKLSKKLGGLGGGKGTGSGGGSSSQGPRPQLGGRVVTIAAAAIVIIWAASGFYTIKEAERGVVTRFGKFSHLVEPGLNWKPTFIDEVKPVNVEAVRELAASGVMLTSDENVVRVEMNVQYRVTNPEKYLYSVTSPDDSLRQATDSALRGVIGKYTMDRILTEGRTVIRSDTQRELEETIRPYDMGITLLDVNFQAARPPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRILEEARAYKAQTILEAQGEVARFAKLLPEYKAAPEITRERLYIETMEKVLGNTRKVLVNDKGGNLMVLPLDQMLKGGNAPAAKSDNGASNLLRLPPASSSTTSGASNTSSTSQGDIMDQRRANAQRNDYQRQGE
Protein: Protein transport protein SEC1 (P30619)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the final stage of protein secretion.
Interaction partners:
- Protein SSO1
- Protein SSO2
- Protein transport protein SEC9
- Synaptobrevin homolog 1
- Protein MSO1
- Synaptobrevin homolog 2
- Exocyst complex component SEC6
- Vesicular-fusion protein SEC18
- Ras-related protein SEC4
- Exocyst complex component SEC15
Sequence:
MSDLIELQRNYLIGVLNQIETKNNLKFLIIDKTVETILSYLFLTPQELLNNVTSVDLIDSPTRKGQSSIEAIYILEPTKYNINCIDADFMVRPPKYRRCHIRFLPGLTNPIFQFFQSKRYIAQNLESFKPIELGFFVKESQFFETLQMEHSLQVFFNNNCKALIPTNVRKIVGSLVSLCVITGEYPIVRYSVSNPVEEEDARNGNAVVNANSLTRSIANAFQIAIDTYARNNPDFPPQNTERPRSILIITDRTLDPFAPILHDFSYQAMAYDLVANVDTQKDIYHYSAENEAGEQEEKVSKLVDLYDPDWIDLKHQHIMDANEYIQGRIKELIAKNPLLVDRSNVKNTTDLLSVVAHLKDFDEERRRLILHKTLVDECLGENAERKLADISAIEQNLSGFGMDFSGEKIKHIIDDLLPALAMKEPTILDKLRYIIAYALFRGGIIELDFIKLLNFIGVTHEHENFQQYLKIFRNYDLIDFKLIKDKPKDKPFQKEWFHDTLVNDPNIYHTSRFVPAVGNILSKVIANPLLLSEQYFPYLKDKPIELLNEEEFQAGLANTSANSSSSLRNPRHKAAWTTKSSNIKKNIPRQRFFYYVIGGISIPEIKAAYDQSNLKNRDIFIGSDEILTPTKFLDEVERLQNPREFFKFKEDQRQQVNPPDFLLREMKPVAQPVSHVHLKSQDNSPKSGTSSPKAAGSLKSEPPEKEKKRSKFSRFLKRKSHHDK
Protein: Eb1, isoform E (LD08743p) (Q9XZ57)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MAVNVYSTNVTSENLSRHDMLAWVNDCLQSQFSKIEELCTGAAYCQFMDMLFPNSVPVKRVKFRTNLEHEYIQNFKILQAGFKKMSVDKIIPIDKLVKGRFQDNFEFLQWFKKFFDANYDGRDYDASAVREGAPMGFGSGAVKSLPGTAASGVSSSYRRGPSATTRPAMTSAVKPISKVLPRTNNAAPASRINACANSTGTVKKNDVSNSVNNQQIEEMSNQVMDMRINLEGLEKERDFYFSKLRDIEILCQEADDAEAHPIIQKILDILYATEDGFAPPDDAPPEDEEY
Protein: Sponge, isoform E (Q9VAS8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Ced-12
- Adapter molecule Crk
- Uncharacterized protein, isoform A
- AT18611p
- Ras-related protein Rac1
- Cdc42 homolog
Sequence:
MWIPSNNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDLSKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLSATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPREGPLAVDPHGIGIVKLYNVHVSSADNAKASSSRGTLRRKTQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDGFSNYIERLHSNCTVFTDLGAADLNEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGPTFRRPFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQCEEKDFHLLPELIIKKSSGKYSPIQASQGTQGIVVSLKLLHGGLGQARQEQPMLFQGSTITRKMGFPDVIMPGDVRNDLFLNLERGEFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQVANYLRLQCRPRDAQAKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDELRLCAEILSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTISIIMEGSNAVLPQLVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVMKLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILHSHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSFRLVESELIDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYASMLSWDRETQSFAPFDNSGQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTEQRVAPATASSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSIPLEDTAAPPVPNRPRSQNFIGNGSMDSPEVPPKRQPTLNSPNAPPLPPRGITPDKRASNPLIFNDFGSGDAVGRRHSQQQQQHGQKYSVVDISYDDPEADQQPHSLPPNFQDGSGGHLSVCFAPNDFRDSGISTTSSRELNHMNLNNLSEDSSSISTITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDFPVPPPPIPPKSLAVSSNGVNFSLDEAHSPHPSTQANTTQLNHIQNPNQNHSTNSHHHLQQQQNGDGDGYSTLQHPMNGLGLPTLPPPPSAVESPMPASAIASSTSSHQHDGGTFXVTICRCHHPPDQPHQPHKPSSSTSTSDSTATDTASESTESSSSTHSMTPPPPPPPPPSSFTHLHHQMAATTHYCQDCLSSPSPPPTIITEQAQVHPTPGSTSAQPHIEHCSCGLSFSVVQDQQEQFPRLLSTRFSTLERQTDGFQVEQVSGCQHHHHHQHSPLYHLPQSSQDAHAQTDFSYAQR
Protein: Polyglutamylase complex subunit TTLL1 (EC 6.3.2.-) (Tubulin polyglutamylase TTLL1) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1) (O95922)
Organism: Homo sapiens (Human)
Function: Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91V51}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q91V51}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q91V51}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q91V51}.
Interaction partners:
- Leucine-rich repeat-containing protein 49
- Nicolin-1
- Tubulin polyglutamylase complex subunit 2
- Tubulin polyglutamylase complex subunit 1
- Centriolar satellite-associated tubulin polyglutamylase complex regulator 1
- Enhancer of mRNA-decapping protein 3
- TBC1 domain family member 19
- SANT and BTB domain regulator of class switch recombination
Sequence:
MAGKVKWVTDIEKSVLINNFEKRGWVQVTENEDWNFYWMSVQTIRNVFSVEAGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELEKEGSPLAEKDENGKYLYLDFVPVTYMLPADYNLFVEEFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSNKEAYVISLYINNPLLIGGRKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGADRELRSRQGQSLGPRAGRSRDSGRAVLTTWK