wanglab/gogpt-training-data huggingface dataset:
Protein: Nitrate reductase alpha subunit (EC 1.7.5.1) (P9WJQ3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: The alpha chain is the actual site of nitrate reduction (Probable). Supports anaerobic growth of E.coli on glycerol in an E.coli mutant lacking endogenous nitrate reductase.
Subcellular location: Cell membrane; Peripheral membrane protein.
Interaction partners:
- Probable respiratory nitrate reductase
- Probable respiratory nitrate reductase
- Nitrate reductase-like protein NarX
- Probable nitrate/nitrite transporter NarK2
- Nitrate/nitrite transporter
- Probable nitrite extrusion protein 1 NarK1
- Probable integral membrane nitrite extrusion protein NarK3
- assimilatory sulfite reductase
- Nitrite reductase small subunit
- Nitrate reductase-like protein NarX
Sequence:
MTVTPHVGGPLEELLERSGRFFTPGEFSADLRTVTRRGGREGDVFYRDRWSHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQQTDYPSVGPDRPEYEPRGCPRGASFSWYSYSPTRVRYPYARGVLVEMYREAKTRLGDPVLAWADIQADPERRRRYQQARGKGGLVRVSWAEASEMVAAAHVHTIKTYGPDRVAGFSPIPAMSMVSHAAGSRFVELIGGVMTSFYDWYADLPVASPQVFGDQTDVPESGDWWDASYLVMWGSNVPITRTPDAHWMAEARYRGAKVVVVSPDYADNTKFADEWVRCAAGTDTALAMAMGHVILSECYVRNQVPFFVDYVRRYTDLPFLIKLEKRGDLLVPGKFLTAADIGEESENAAFKPALLDELTNTVVVPQGSLGFRFGEDGVGKWNLDLGSVVPALSVEMDKAVNGDRSAELVTLPSFDTIDGHGETVSRGVPVRRAGKHLVCTVFDLMLAHYGVARAGLPGEWPTGYHDRTQQNTPAWQESITGVPAAQAIRFAKEFARNATESGGRSMIIMGGGICHWFHSDVMYRSVLALLMLTGSMGRNGGGWAHYVGQEKVRPLTGWQTMAMATDWSRPPRQVPGASYWYAHTDQWRYDGYGADKLASPVGRGRFAGKHTMDLLTSATAMGWSPFYPQFDRSSLDVADEARAAGRDVGDYVAEQLAQHKLKLSITDPDNPVNWPRVLTVWRANLIGSSGKGGEYFLRHLLGTDSNVQSDPPTDGVHPRDVVWDSDIPEGKLDLIMSIDFRMTSTTLVSDVVLPAATWYEKSDLSSTDMHPYVHSFSPAIDPPWETRSDFDAFAAIARAFSALAKRHLGTRTDVVLTALQHDTPDEMAYPDGTERDWLATGEVPVPGRTMSKLTVVERDYTAIYDKWLTLGPLIDQFGMTTKGYTVHPFREVSELAANFGVMNSGVAVGRPAITTAKRMADVILALSGTCNGRLAVEGFLELEKRTGQRLAHLAEGSEERRITYADTQARPVPVITSPEWSGSESGGRRYAPFTINIEHLKPFHTLTGRMHFYLAHDWVEELGEQLPVYRPPLDMARLFNQPELGPTDDGLGLTVRYLTPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSPGDAAKINVRDNDWVEAVNANGIYVCRAIVSHRMPEGVVFVYHVQERTVDTPRTETNGKRGGNHNALTRVRIKPSHLAGGYGQHAFAFNYLGPTGNQRDEVTVVRRRSQEVRY
Protein: Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) (Q9NQG5)
Organism: Homo sapiens (Human)
Function: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
Subcellular location: Nucleus {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB2
- Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
- Regulation of nuclear pre-mRNA domain-containing protein 1A
- Regulation of nuclear pre-mRNA domain-containing protein 2
- ATP-dependent DNA helicase Q5
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB9
Sequence:
MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGGLAPLPSAGDLFSTD
Protein: Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34) (Q3SY84)
Organism: Homo sapiens (Human)
Function: Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22592156}.
Interaction partners:
- R-spondin-2
- Fibroblast growth factor 5
- Keratin, type I cytoskeletal 25
- Keratin, type I cytoskeletal 27
- Keratin, type II cytoskeletal 74
- Keratin-associated protein 11-1
- Keratin, type I cuticular Ha5
- Keratin, type II cuticular Hb5
- Keratin-associated protein 3-1
- Keratin-associated protein 9-3
Sequence:
MSRQFTCKSGAAAKGGFSGCSAVLSGGSSSSFRAGSKGLSGGFGSRSLYSLGGVRSLNVASGSGKSGGYGFGRGRASGFAGSMFGSVALGPVCPTVCPPGGIHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRNVRDVVEDYKKRYEEEINKRTAAENEFVLLKKDVDAAYANKVELQAKVESMDQEIKFFRCLFEAEITQIQSHISDMSVILSMDNNRNLDLDSIIDEVRTQYEEIALKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRSEIENVKKQASNLETAIADAEQRGDNALKDARAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEFPSPVSISIISSTSGGSVYGFRPSMVSGGYVANSSNCISGVCSVRGGEGRSRGSANDYKDTLGKGSSLSAPSKKTSR
Protein: Secretory pathway Ca2+-ATPase pmrA-Aspergillus niger (A2QFG4)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MSRSATPALPFHNAQIPDSRPRSTTPADVRSSPSPSTSTSTYSLLDPQETAERLQTSLVHGLNPAEAEVRLAQEGPNELPHEEPEPIWLRFLKQFKETLILLLLASAAISFFMGNYDDAVSITLAVTIVVTVGFVQEYRSEKSLEALSRLVPHHAHLIRDVPLNGPPVAGTIPPAPGAEMELQELRSKSASISTAVKASTTVPATELVPGDLVLFTVGDRIPADIRITAATYLSIDESNLTGENEPVVKYPDAIRSPKHLPSHSPKIVSPPRSPFYDAPASGAVGADIRLNEQHNIAFMGTLVRSGYGQGIVIGTGAKTEFGSISASLQEIESPRTPLQLSMDRLGQELSYISFGVIGLIVLIGLIQGRKLLEMFTIGVSLAVAAIPEGLPIIVTVTLALGVLRMAKRGAIMRRLPSVETLGSVNVVCSDKTGTLTLNHMTVTKMWHFDCPEPFEVHNDISSLTPGPAARTVLRIGNIANNARLSRVHANSPASASSAAVLSSTDDRASGSIRSRWVGQPTDVAILDLLDTFGEDDVRERISARVAETPFSSERKWMGVIIGNGTSGDNVAYIKGALEQVLTRCDTYLTKDGREVILDEPRRQSIRHAAEHMAAEGLRVLAFASGAVRDTSRGRAFGSRSGTPVSKSSSQSDDDDRYNGLVFAGLVGMNDPPRKDVHKSIRRLMAGGVRVIMITGDAETTAVAIAKKLGMPVSDAPGSRPVMNGHEIDRMSTQELAQAISSTSVFARTSPDHKMKIVRALQSRGDVVAMTGDGVNDAPALKKADIGISMGKLGTDVAKEAADMILTDDDFSTILRAIEQGKGIFYNIQNFITFQLSTSVAALSLVLLSTTLGFKNPLNAMQILWINILMDGPPAQSLGVEPVDPSIMNRPPRPRNARVLTRPLVQRVLTSAMMIMLGTLAIYIHEMGDADDTANPGVHSRVVTAHDTTMTFTCFVLFDMFNALTCRSEGKSVLRGEISLFGNKMFNYAVLGSLAGQACVIYLPFLQRIFQTEPLGFGHLFRLMLFLIL
Protein: Tenascin-X (Q3TAQ2)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MNLYGIYSGQRVGPVSAVGVTAAEEEPPSPTEPSTEAPESTEEPLLGELTVTGSSPDSLSLSWTVPQGEFDSFTVQYKDSDGRPQVMRVGGQEREVIVRDLDPGRKYKMNLYGLHEGRRVGPVSTVGMTEKEALTTQVVPTTTPEPPPKKPHLGELTVTDATSDSLSLSWTVPEGQFEQFVIQYKNGDGQPKVVRVPGHEDQVTISGLEPDHKYKMNLYGIHSGQRFGPVSTVGVTTAVEEPPSPTEPSIEAPEPTEEPLLGELTVTGSSPDSLSLSWTVPQGDFDSFTVQYKDSDGRPQVMRVGGQEREVIVRDLDPGRKYKMNLYGLHEGRRVGPVSTVGVTASLTTEPPIEPRLGELAAVEVTSSTVHLSWTVAQGPFDSFLVQYKDTQGQPQMVPVSGDLGEVTVSGLEPARKYKFQLFGLKDGKRHGPVSTEAKTVSDAKLLPRLGELTVTDTNQNSVGLSWTVPEGEFDSFLVQYKNRGGQVQVVPAAADQREVTISSLEPNRKYRFLLFGLIGLKRLGPVSVEGTTAPVEKTPQPRLGELSVTEETSDSMHLSWSVVQGPFDSFLVQYKDRDGQLQTVSLAADQREVTIEGLQPGRKYKFLLYGLTGGKRLGPISALGVTASEVDISAPDHTEPPHAPGLGTLAVTEATPDSLRLSWAVARGPFDSFVVQYQDTENETQALLVDGDQDKVLISGLEPKTSYKFFLYGLREGTRHGPVSVEGTTDPVPAGQGPGDPGPRLSQLSVSDVTTSSLRLNWEAPLGAFDSFLLRFGVPLLSTLEQNPRTLQQRELMVPGVRRSAMLRDLRPGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESPRDLQFSDIGETSAKVKWVPPTSRVDSFKISYQLADGGEPQSVQVDGRTQTQILQGLIPDTRYEVTVVSVRGFEESEPLTGFLTTVPDGPTQLRALNLTDGSALLHWKPPHKPVDKYDVEVESPGAPPLQASAPGSAVDYPLTDLALDTNYTATVRGLRGPNFTSPASITFTTGLKPPQDLEAKEVTPRTALLTWTEPEVPPTGYLLSFDTPGGQIQEILLPAGTTSHRLLRLFPSTFYSAQLRAIWGESLTPPVLTSFTTGGLRIPFPRDCGEELKNGPSASKTTTIFLNGNRERPLDVFCDMETDGGGWLVFQRRMDGQTDFWRDWEEYAHGFGNISGEFWLGNEALHSLTQAGDYSLRVDLRAGKEAVFAQYDFFRVDSAKENYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFQVPTRGT
Protein: Zinc metalloproteinase nas-5 (EC 3.4.24.-) (Nematode astacin 5) (P91828)
Organism: Caenorhabditis elegans
Function: Metalloprotease.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Homolog of Odr-2
- Uncharacterized protein
- Signal peptide protein
- Spindle and kinetochore-associated protein 2
- BPTI/Kunitz inhibitor domain-containing protein C02F12.5
- Neuropeptide-Like Protein
- Probable prefoldin subunit 5
- DUF19 domain-containing protein
Sequence:
MDIKQLLLSIILTVSVVNGRGRRINIYGAENGKSDIVQLRGPAEQLVYSSPIRERRPIFRNALLSNSPLRWSKMQDLDGNYLIPYVISGNYDTVERDTIKTAMEKIANNTCIRLIPRTNQPDYAEINNKKGQGCYASIGRFPGKNVVMLESNDDQSCIQEDTVIHELFHVIGLWHEHMRADRDAFINVLYKNIEPAQYPQFEKLSSRDATTYSVPYDYNSVMHYDENAFAKPGKISMMTKDSKFQKVIGHPKDASSNDYKKVCAIYHCSKCMHQDFQQIVEQEHIELNNPIITNAPVQQGDSCTDRLGICPMLKSREMLNCKVMATFCCSSCSAPTSTTTTTSGTPSDGSLWQRIKSIFQ
Protein: Thrombospondin-4-B (Thbs4-B) (Q8JGW0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment. May play a role in ER stress response (By similarity).
Subcellular location: Endoplasmic reticulum {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}. Secreted {ECO:0000250}. Secreted, extracellular space {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Platelet glycoprotein 4
- Syndecan 4.
- Integrin alpha-5 precursor
- Integrin, alpha 10
- Scleraxis bHLH transcription factor a.
- Integrin alpha-6 isoform X1
- Integrin alpha-11a precursor
- Integrin alpha-2 isoform X1, tandem duplicate 2)
- Integrin, alpha 6b
- Integrin, alpha 6,-like
Sequence:
MAGTMHLLTAVSLILMLSSANAESTVYNLLTSPDCLPDLLHGGLAEQGVTELYILTTFRIQPGTGNTIFSLYNPRDNSKYFEFSVFGKANKAILRYLRRDGRMSAVTFNKLNLADGEKHRLLFHLKGLEVGHPGGFPHSQGALPVPGVELHLDCRLVETLRDLPAVFNGLNNHQAVELKTMQGKAQEGLEELKLAYGDSVENVASLQDCHTQSDSVQALGLNTKQLTTQMLELTKVINELKDVLIQQVKETSFLRNTISECQACGLSGAEVVKPKCAPGVCFRDDMCIETAEGVECGPCPDGYTGDGYSCDDVDECQFNPCFPGVRCVNMAPGFRCEACPLGFTGKPLEGVGVAYAQTHKQVCDDIDECKGPDNGGCTANSICVNSVGSYQCGRCKTGFTGDQIRGCKPEKSCGNRLQNPCDPNAQCTEERDGTITCQCGIGWAGNGYLCGKDTDIDGYPDERLRCRDPTCRKDNCVTVPNSGQEDADGDGKGDACDPDADGDGILNEQDNCWLTPNINQQNSDKDSHGDACDNCVRVDNPDQRDTDSDGLGDACDDDMDGDGLKNFLDNCQRVKNRDQLDRDGDGVGDACDSCPDIPNPNQSDIDNDLVGDSCDTNQDSDGDGHQDSKDNCPMVINSSQLDTDKDGIGDECDDDDDNDGIPDSLPPGPDNCRLVPNPEQIDDNNDGVGDICESDFDQDKVIDRIDNCPENAEITLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFSGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVKSKTGPGEHLRNSLWHTGDTNDQVRLLWKDPRNVGWKDKVSYRWYLQHRPQVGYIRVRFYEGTELVADSGVTIDTTMRGGRLGVFCFSQENIIWSNLKYRCNDTIPEDFQEFSTQHGMDPL
Protein: Protein regulator of cytokinesis 1 (H0YL53)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKPVAASTCSGKKTPRTG
Protein: Histone H3-7 (Q5TEC6)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Interaction partners:
- WD repeat-containing protein 5
- Chromobox protein homolog 5
- Chromobox protein homolog 3
- Histone H4-like protein type G
- Histone H4
- Chromobox protein homolog 1
- DNA
- Histone H2A type 2-C
- DNA
- Histone H2B type 2-E
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQEFKTDLRFQSSAVMALQEAREAYLVGLFEDTNLCAIHAKRVTIMPKDIQLVSRIRGERA
Protein: Dyschronic, isoform F (B7Z049)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Interaction partners:
Sequence:
MRLGGSGIPYDGDPLTMSAAGNDYAELCDLGPSRWSARPYGYNATAAAAASFGLGPSMGGTQSSSSVPTGGSAGLSGHHLRSSGAPGPSSFEAEDIGMAFGMISPPPGSGPYVGSSAAAGGSRVGNSTSSLRGAGGRSGLYYSPPGTSYTIVERPHSPHYYFNSAGVPTKGGSLPGRGSAYLSSSPASHMAAGTAGTLPTSTAASGRSMGQHASSNGNKKRPISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWDAYSPTGTRARRKGQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPARDLPVSFLEDLFYDTDTIYT
Protein: Cyclin-T1-4 (CycT1;4) (Protein AtCycT-like2) (Q8GYM6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cyclin-dependent kinase C-1
- Cyclin-dependent kinase C-2
- Cyclin-dependent kinase D-2
- Cyclin-H1-1
- Protein RNA-directed DNA methylation 3
- Transcription elongation factor SPT4 homolog 2
- Transcription elongation factor SPT4 homolog 1
- Pentatricopeptide repeat-containing protein At4g30825
- Protein RTF1 homolog
- FACT complex subunit SSRP1
Sequence:
MAGVLAGDCSFGESGVSSYSRNSNEKQDEVARWYFGRKEIEENSPSRLDSIDLKKETYLRKSYCTFLQDLGMRLKVPQVTIATAIIFCHRFFIRQSHARNDRRTIATVCMFLAGKVEETPRPLKDVIVVSYEIIHKKDPTTAQKIKQKEVYEQQKELILNGEKIVLSTLGFDFNVYHPYKPLVEAIKKFKVAQNALAQVAWNFVNDGLRTSLCLQFKPHHIAAGAIFLAAKFLKVKLPSDGEKVWWQEFDVTPRQLEDVSNQMLELYEQNRVPASQVSEVESSVGGGSAHHVGSRPSARLTHEHSNSDNLGGSTKATQNRSNDNGSGEAGSVITEQKGERDTETKDSMHTESHPAHKSRSGVEAPGEDKIEKAGAHFPEDDKSRIVGTADVTVSQSPKDIKMFRDKVKAKLEAKKVQGEKTRKKDLVDEDDLIERELEDVELAVEDDKDIQNKSSMGTEHGEILDGNNLVVNTEEGEMIDDVSSTMPSRKRKMESPCEKQLGEGKRRHDNSENVEEGQKTNPGGSSHSYGDREPRRHSQER
Protein: Adenylate kinase, putative (EC 2.7.4.3) (Q38BZ1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Adenylosuccinate lyase
- Adenosine kinase
- Adenosine kinase
- adenine phosphoribosyltransferase
- adenine phosphoribosyltransferase
- Pyruvate kinase
- Phosphodiesterase
Sequence:
MHVFLTGPPGSGKTSVSTVLKERYGFCYVTPIEAVSHAVEYSDTDVGDKLRRYVDEGEPIPDDLLARAVADATRGPDCTNGFLLNDFPKTAEQARHLKAEGIEPDAIVVLSVPDSLLVDRHAGRWVHPSSGRVYHTFYNPPNVKGRDDVTGQPLVQRPEDTEEAVHQGLVKYYESIRGLRAVYGDPRLWHTVDGFASLDSVHVSICRVLDPIIADKTRRWWSKLFWWSS
Protein: Protein FAM185A (Q8N0U4)
Organism: Homo sapiens (Human)
Interaction partners:
- Peroxisomal membrane protein PEX13
- Peroxisomal targeting signal 2 receptor
- Peroxisomal targeting signal 1 receptor
- PEX5-related protein
Sequence:
MLAPCSGWELGCFRLCLRQVRLWAGAGRWACWACQARPYSSGGSERWPGSETEVPPPGPGRRTLKEWTLQVSPFGRLRARLPCHLAVRPLDPLTYPDGDRVLVAVCGVEGGVRGLDGLQVKYDEDLEEMAIVSDTIHPQASVEVNAPLKFGLDIKSSGSGCVKVQSIEGDNCKIETEHGTSILQSVKGQKLHVQTKGGKVICLGTVYGNIDIHASDKSAVTIDKLQGSSVTVSTEDGLLKAKYLYTESSFLSSAAGDITLGSVHGNITLQSKMGNITVDSSSGCLKASTNQGAIDVYVSQLGKVELKSHKGSIIVKVPSSLQAHLQLSGKEVDVNSEVHVQEMAEVRKDDVVTVTGLMNQASKREKWIKADAPKGTVSFRRQSWFQSLKLQD
Protein: Claudin domain-containing protein 1 (Membrane protein GENX-3745) (Q9NY35)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Palmitoyltransferase ZDHHC5
- Golgin subfamily A member 7
Sequence:
MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDVVTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA
Protein: Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (rCNT2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside cotransporter) (SPNT) (Solute carrier family 28 member 2) (Q62773)
Organism: Rattus norvegicus (Rat)
Function: Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Accepts purine, analogs of purine nucleosides and uridine, and exhibits high affinity for adenosine. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:O43868}; Multi-pass membrane protein {ECO:0000255}. Apicolateral cell membrane {ECO:0000250|UniProtKB:O43868}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Equilibrative nucleoside transporter 2
- Equilibrative nucleoside transporter 1
- Equilibrative nucleoside transporter 3
Sequence:
MAKSEGRKSASQDTSENGMENPGLELMEVGNLEQGKTLEEVTQGHSLKDGLGHSSLWRRILQPFTKARSFYQRHAGLFKKILLGLLCLAYAAYLLAACILNFRRALALFVITCLVIFILACHFLKKFFAKKSIRCLKPLKNTRLRLWLKRVFMGAAVVGLILWLALDTAQRPEQLISFAGICMFILILFACSKHHSAVSWRTVFWGLGLQFVFGILVIRTEPGFNAFQWLGDQIQIFLAYTVEGSSFVFGDTLVQSVFAFQSLPIIIFFGCVMSILYYLGLVQWVIQKIAWFLQITMGTTAAETLAVAGNIFVGMTEAPLLIRPYLADMTLSEIHAVMTGGFATIAGTVLGAFISFGIDASSLISASVMAAPCALALSKLVYPEVEESKFKSKEGVKLPRGEERNILEAASNGATDAIALVANVAANLIAFLAVLAFINSTLSWLGEMVDIHGLTFQVICSYVLRPMVFMMGVQWADCPLVAEIVGVKFFINEFVAYQQLSQYKNKRLSGVEEWINGEKQWISVKAEIIATFSLCGFANLTSIGITLGGLTSMVPQRKSDLCKLVVRALFTGACVSFISACMAGILYVPRGAETDCVSFLNTNFTNRTYETYVCCRELFQSTLLNGTNMPSFSGPWQDKESSLRNLAKCCDLYTSTVCA
Protein: GTP-binding protein rho2 (Q10133)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity. Regulates the synthesis of alpha-D-glucan through activation of pck2.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9405296}; Lipid-anchor {ECO:0000269|PubMed:9405296}. Note=Found at the growing tips of interphase cells and at the septum prior to cytokinesis.
Interaction partners:
- Protein kinase C-like 2
- Probable Rho-type GTPase-activating protein 4
- Protein kinase C-like 1
- Probable Rho-type GTPase-activating protein 3
- Probable Rho-type GTPase-activating protein 2
- Probable Rho-GTPase-activating protein 7
- MAP kinase kinase kinase mkh1
- Mitogen-activated protein kinase spm1
- Rho GDP-dissociation inhibitor
- Rho-type GTPase-activating protein 1
Sequence:
MLQSQPIRRKLVVVGDGACGKTSLLSVFTLGYFPTEYVPTVFENYVSDCRVDGKSVQLALWDTAGQEEYERLRPMSYAKAHIILVGFAIDSPDSLENVSTKWIEEINTLCPNVPFILVGMKADLRSDPVAIEEMRRRNQNFVKSQQAELVAQRIGARKYMECSSLTGDGVDDVFEAATRAALTVRDSENDKSSTKCCIIS
Protein: Probable transcriptional regulator SLK1 (AtSLK1) (Protein SEUSS-like 1) (Q0WVM7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription regulator that functions in the development of the carpel margin meristem similarly to SEUSS (SEU). In association with SEU, supports organ development from meristematic regions by facilitating auxin response and thus organ initiation, and by sustaining meristematic potential through the maintenance of PHABULOSA expression. DNA-binding adapter subunit of the SEU-SLK1 transcriptional corepressor of abiotic stress (e.g. salt and osmotic stress) response genes.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcriptional corepressor LEUNIG_HOMOLOG
- Transcriptional corepressor LEUNIG
- Cytochrome P450 714A2
- At5g65160
- At1g68780
Sequence:
MNRTVVSGAVESSFSLTDAVGTEALNMQRSSGINNNMRIPTSPMSFSSNSVNIPGSLVLDGSAASMQHLPQQQQQQLLQQQTGQGSVPMRENNYSHVDKKPRLEVKQEDMLQQQILQQLIQRQDPTGRNPQMQALLQQQRLRQHQQMLQSMSPSQRLQLQQQQQLRQQLQQQGTQQIPPNVRPYEVGVCARKLMMYLYHLQQRPAENCITYWRKFVAEYFSPRAKQRLCLSQYESAGHHALGMFPQAAPDMWQCDLCGTKSGKGFEATFDVLARLIEIKFASGIIDELLYLDHPRENRFPNGLMMLEYRKAVQETVHEQFRVVREGHLRIIFSQDLKILSWEFCARRHEELLLRRLIAPQVNQLLQVAQKCQSTISESGSEGVSQQDLQSNSNMVLGAGRQLAKFMELQSLNDLGYPKRYIRTLQISEVVKSMKDLMNFTGEQKIGPIEGLKRLLEQTVTVKLQKQKMQEMEQFGNNGAINGPVQAQMVLTSGTMNGSTGNNTNNHHQIVGRGAMSGPAEGQMVISSGTVSGATANNNSNNHNQIVGRGAMNGSAQAAAALTNYQSMLMRQNAMNNPNSNTGKQEGFSSQNPTPNSNQSPSSSSQQRHNLVTGGFPNSPQMQQQQRTMNGPTNILPQNHPHQLQSPHSHGNTPEQQMLHQLLQEMSENGGSVQQQQAFSGQSGSNSNAERNTTASTSNISGGGRAPSRNNSFKAASNNNLHFSEDISITDHDFSEDGFFNNNDIYGGL
Protein: Uncharacterized protein (Q38A63)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Acyl carrier protein
- PROP1-like PPR domain-containing protein
- Dehydrogenase-like protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Translation initiation factor IF-2
- Treble clef zinc finger domain-containing protein
- Small ribosomal subunit protein uS5 C-terminal domain-containing protein
- Uncharacterized protein
Sequence:
MWQRLRFDRLSSSVRRTNLNPLKPCAALTEQRAELRNLHQYPTARHKSLVKDRLRFARNWWLTGGNNYELVHEVGHEREATECFAEYAQDSSRDVYLMSTNRLSDLPPGDRLKAIVGLMRSRWEVKDANRGYDKAKLLLQALECFSEMKASGQIGDFNSLPEPDQDTFLQYVEGCSRFAQACSHSHPDAVRVLLRAAQICEEMRCVEKRDEMIQVTEAAANRMDRAYAFSRPHDTLRAAPPSLHENEDCVRLKNTEELRRRFGNTAPHVLEKPKRVDCLRIHRNRPLLLHPMKDNNKLLELSKLPARPEFDSWTSHQT
Protein: Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) (P32592)
Organism: Bos taurus (Bovine)
Function: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P05107}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P05107}. Membrane raft {ECO:0000250|UniProtKB:P05107}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P05107}.
Interaction partners:
- Integrin alpha-L
- Intercellular adhesion molecule 1
- Integrin subunit alpha M
- VWFA domain-containing protein
- Vascular cell adhesion protein 1
- Vascular cell adhesion protein 1
- Filamin A
- Intercellular adhesion molecule 3
- TYRO protein tyrosine kinase-binding protein
- Junctional adhesion molecule A
Sequence:
MLRQRPQLLLLAGLLALQSVLSQECTNYKVSTCRDCIESGPGCAWCQKLNFTGQGEPDSIRCDTRAELLSKGCPADDIMEPKSLAETRDSQAGSRKQLSPQEVTLYLRPGQAVAFNVTFRRAKGYPIDLYYLMDLSYSMVDDLVNVKKLGGDLLRALNGITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKECQPPFAFRHVLKLTDNSKQFETEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKSSNEFDYPSVGQLAHKLAESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSEDSRNVVELIKNAYNKLSSRVFLDHSTLPDTLKVTYDSFCSNGKSQVDQPRGDCDGVQINVPITFQVKVTATECIQQQSFTIRALGFTDTVTVRVLPQCECQCRDASRDGSICGGRGSMECGVCRCDAGYIGKNCECQTQGRSSQELEGSCRKDNSSIICSGLGDCICGQCVCHTSDVPNKKIYGQFCECDNVNCERYDGQVCGGEKRGLCFCGTCRCDEQYEGSACQCLKSTQGCLNLDGVECSGRGRCRCNVCQCDPGYQPPLCSECPGCPVPCAGFAPCTECLKFDKGPFAKNCSAACGQTKLLSSPVPGRKCKERDSEGCWMTYTLVQRDGRDRYDVHVDDMLECVKGPNIAAIVGGTVGGVVLVGILLLVIWKALTHLSDLREYHRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES