wanglab/gogpt-training-data huggingface dataset:
Protein: Lithostathine (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) (P10758)
Organism: Rattus norvegicus (Rat)
Function: Might act as an inhibitor of spontaneous calcium carbonate precipitation.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MTRNKYFILLSCLMVLSPSQGQEAEEDLPSARITCPEGSNAYSSYCYYFMEDHLSWAEADLFCQNMNSGYLVSVLSQAEGNFLASLIKESGTTAANVWIGLHDPKNNRRWHWSSGSLFLYKSWDTGYPNNSNRGYCVSVTSNSGYKKWRDNSCDAQLSFVCKFKA
Protein: Ribosomal RNA-processing protein 14-C (Ribosome biogenesis protein rrp14-C) (O43082)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in ribosome biogenesis and cell polarity. Required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Brix domain-containing protein C1B9.03c
- Probable rRNA-processing protein ebp2
- Protein mak16
- Ribosomal RNA-processing protein 1 homolog
- Probable nucleolar GTP-binding protein 1
- Uncharacterized RNA-binding protein C1827.05c
- Ribosomal RNA-processing protein 14-N
- Brix domain-containing protein C4F8.04
- Pescadillo homolog
- Ribosome biogenesis protein brx1
Sequence:
METTEGKNDLRAKLAEKIQTFRSQRKATEKVDRALLLQRRKEKAKARAEAKKLAKKESKAKQESKVAAYDTGNSSDNIADEENDNHKSTITYGTLIVGDDKFSNGKLKVAGKKRGPTDVFGALKHLEAKKRRIESMDEEKRRKIEESDKWHRVLLQAEGKKLKDNEQLLKKSIRRKEKEKKKSSDAWKERKDNEKKAMLMRQQRREENLKKRRESKKSKKGKAPKKKKPSKKK
Protein: Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5) (Q83730)
Organism: Myxoma virus (strain Lausanne) (MYXV)
Function: Substrate-specific adapter of SKP1-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins including CDKN1B. Disappearance of host CDKN1B correlates with cell cycle progression through the G0/G1 checkpoint. Therefore, viruses in infected cells are protected from diverse innate host antiviral responses normally triggered by G0/G1 cell cycle arrest.
Interaction partners:
Sequence:
MDLYGYVSCTPRIRHDVLDGLLNVYDPDELCSRDTPFRLYLTRYDCTPEGLRLFLTRGADVNGVRGSRTSPLCTVLSNKDLGNEAEALAKQLIDAGADVNAMAPDGRYPLLCLLENDRINTARFVRYMIDRGTSVYVRGTDGYGPVQTYIHSKNVVLDTLRELVRAGATVHDPDKTYGFNVLQCYMIAHVRSSNVQILRFLLRHGVDSSRGLHATVMFNTLERKISHGVFNRKVLDFIFTQISINEQNSLDFTPINYCVIHNDRRTFDYLLERGADPNVVNFLGNSCLDLAVLNGNKYMVHRLLRKTITPDAYTRALNVVNSNIYSIKSYGMSEFVKRHGTLYKALIRSFVKDSDREIFTYVHIYDYFREFVDECIRERDAMKADVLDAVSVFDTAFGLVARPRWKHVRILSKYVRGVYGDRVKKILRSLHKRRFKTDRLVRRIADLCGPDGLWTRLPVEVRYSVVDYLTDDEIHDLFVKIHA
Protein: REL proto-oncogene, NF-kB subunit (A0A8I6ABJ7)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MASSGYNPYVEIIEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQIMNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGPERRPLFFQNLGIRCVKKKEVKEAIILRISAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNFTTALPPIVSNPIYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGIFSQADVHRQVAIVFRTPPYCRAIVEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDAYGNKSKKQKTTLIFQKLLQDCEKRIIPSHFPEKTRAVPLESIGETRFIKKESNLFSHGTVLPETPRSSGVPGQAEPYYSSSGSISNALPHHPSAMPSMVHQPASWSPVTHPTSHPGSTNTLSSFPAGQLSSNSQGVLPFLDGAGMNDLSASNACLFSTDNLARMETPSMSPTDLYSISDVNMLTNRPVSVMTSSTDGMGDTDHPRLVSVNLENPSCNSRLDPRDPRQLHQMSTASMSAAGTSSSSVFVSQSDTFNRPHFSCIDNGLTNEPGLANDAHHPNFAQSSQYSGIDALQSEQLGDSFEYSFFKI
Protein: Aberrant root formation protein 4 (Q84VX3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the initiation of lateral roots independent from auxin signaling. May function in maintaining the pericycle in the mitotically competent state needed for lateral root formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:14731255}.
Interaction partners:
- Uncharacterized protein At3g06530
- rRNA biogenesis protein RRP5
- Nucleolar-like protein
- Protein SLOW WALKER 1
- KRR1 small subunit processome component
- Nucleolar protein
- F18K10.11 protein
- Putative WD-repeat membrane protein
- Probable U3 small nucleolar RNA-associated protein 11
- Protein NUCLEOLAR COMPLEX ASSOCIATED 4
Sequence:
MVKFAIINTLTVNETWAKLKSFGVMESSIEGSSESTTVTTSPSRRVRELLALCFSSVEEAGGFQDFESFVTELVSCLDSLYENVALDANNELENDVIEEVLDEILKVLSSPQMDQDVIDALSFHLPKVTSKFADISSRCLQLVEEIVDRFVEACNPRDMLSILCEALDAARCYHSASTCSTPLLHGLSKVFILIQRRHYEQLKVAVPIVLNVLKDISLETDVQVEDLFDKALGIASSIRDVSSKLNNEEEAKVRCLLCLYVIQITAIISVSIRDKAASCIPLVIQLEPFLTSCGLTHLGLITGNDTEKLMSTVAGDDDEFITSFPDISLGASLLFICAKISHEVAEAANAVLGSVVDELQNNPVKRWQAYGMLKYILSSGDLLWEFKRHAIEFLLDITKGVTSSQCNDEQIDCSDYTPGIYATLQAVTLLIMYAPDADLRKKTFEALKRVLSDIPAPHRFDVLRALVTNSRSPSMTAILLGLVKDSMSKSSLQDTDCAAVDTHVIELVELVLRPPQGGPPLLPDQSDAILAALNLYRFALLFESRECEAGKERSKVGSDILSKKNLEKAYKEWLLPLRTLVSCSIAENLKEDHGQESSLDDVGLLNPIELVLYRCIELVEEKLKSH
Protein: Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2) (Q8BG99)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Pre-B-cell leukemia transcription factor 1
Sequence:
MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSATASTPVPSAPIDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQQQGGTPGTNPDGSINLDNLQSLSSDNATMAMQQAMMAAHDDSLDGTEEEDEDDMEEEEEEEEELEEEADELQTTNVSDLGLEHSDSLE
Protein: Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta) (Q4FKA6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Interaction partners:
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor, putative
- Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like C-terminal hexapeptide domain-containing protein
- Translation initiation factor eIF-2B alpha subunit, putative
- protein-synthesizing GTPase
- Elongation initiation factor 2 alpha subunit, putative
- Translation initiation factor eIF2B subunit gamma
- Selenocysteine-specific elongation factor
- mannose-1-phosphate guanylyltransferase
Sequence:
MSSAVGAAMSLIGQDSDEARAAVRLQRELKRRKDALRKLEKKMKALKPSDTVFQVTMEEMEKLKNEVDQLEKGVASQQEEKKSSVESKSPRRGTSAAPRLVGSPRKDPLKSLTPRGAGVKTPKALSTPRIRRDLAPSAHTSRQKAVSKEERRAGYVTDDLGERVAVTVSAGTAGSQMRDEQLFVDVQAVVQEHIDRSVTGSPCAIVSPRNDIDCEGVHYQVAELALMMESMMVVGGNARTFAMIEAFKALLKSSPTLSGSTVNHFPSKEFESLIKVNFDFLCRSRAPSAGMTNAKDSLVRRVVALLSQREKARFSADDLFASLRSARLESSMCVQSTAVGRDRNETCFLDISPRDLALKVLGAIERELQLSIKSIVEDRAEPHLSSNDTILVFGRSSTVELILLAAANNPRLASKPKVIVVDSAPLYEGRALATRLSCSGLDVTYGLITTCCTLMPRCTRVFIGAAAVLQNGDVFSRCGTAVVVSSAKQFRKPVLCFSESIKFVPEVWLGNLGQNTRLTDMRQPHRGELRIRSPGNWSPLSHGSRELMDVKKGWGQCNSGGLSGRGTNEEPSRLLQTDAPPSSGYLYDLTPAAYIDMIICEMGCLHTSAILAALRDREDRDLYLMSAT
Protein: Nuclear factor 1 (O70185)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000690}.
Interaction partners:
- Neurofibromin
Sequence:
MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPNSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSTSPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNSSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLTMTDTKPITTSTEAYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQAETSN
Protein: Putative transporter C543.05c (Q9HGM6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MNKKDKKFNYIFGSEIVNDVKKRLPYYKSDWIDACHYRVLPACLNIYFSNLLPELAFALDMFAKTNNSFGVNEVLLASVLGSVVFALLSSQPLCIVGVTGPITVFNYTVYDIMHDRGTPYFPFLCWICLWSMIFHFIIAIANGVYFVKHITKFSCEIFGLYVAFIYLEKGVQVLCDQLKYGLTNTFLSITIALLFLMVGWLCDTVGKSSLFSYKVRILLLDYGLVASIIFFSGFQHIGKMREVSLAKLPTTKAFEPTLSRSWFIKFWKIPVGDVFLAIPFSIVLTILFYFDHNVSSVMAQDPSFPLTKPAGFHWDFFLLGITTGVSGILGIPAPNGLIPQAPMHTAALCVKRVDYDEDEIEKTHKEVIDRVVEQRASNFIQGLMTVGTMTGPLLLVLHQIPQCVLAGLFWVMGFSAIFGNGITQNVIWMLSDRKVVSKNHTLNHCSSKRVVWLYTILQLIGFGATFAITQVDKASIGFPIIILLLIPFRTYCMPKWFLEEDLEILDENVGIIAYQKV
Protein: Axin-1 (Axis inhibition protein 1) (Protein Fused) (O35625)
Organism: Mus musculus (Mouse)
Function: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16815997, ECO:0000269|PubMed:19141611}. Nucleus {ECO:0000250|UniProtKB:O15169}. Cell membrane {ECO:0000269|PubMed:16815997}. Membrane {ECO:0000269|PubMed:19141611}. Note=On UV irradiation, translocates to the nucleus and colocalizes with DAAX (By similarity). MACF1 is required for its translocation to cell membrane (PubMed:16815997). {ECO:0000250|UniProtKB:O15169, ECO:0000269|PubMed:16815997}.
Interaction partners:
- Glycogen synthase kinase-3 beta
- Low-density lipoprotein receptor-related protein 6
- Adenomatous polyposis coli protein
- Casein kinase I isoform alpha
- Glycogen synthase kinase-3 alpha
- Segment polarity protein dishevelled homolog DVL-1
- APC membrane recruitment protein 1
- Low-density lipoprotein receptor-related protein 5
- Catenin beta-1
- Segment polarity protein dishevelled homolog DVL-2
Sequence:
MNVQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPYLRWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDSNGIVSRQTKPATKSFIKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGMSGYLPTLNEDEEWKCDQDADEDDGRDPLPPSRLTQKLLLETAAPRAPSSRRYNEGRELRYGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESIQVNGRVPLPHIPRTYRMPKEIRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGEMPSGPMASHKLPSVPAWHHFPPRYVDMGCSGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSGHVAKTAVLGGTASGHGKHVPKLGLKLDTAGLHHHRHVHHHVHHNSARPKEQMEAEVARRVQSSFSWGPETHGHAKPRSYSENAGTTLSAGDLAFGGKTSAPSKRNTKKAESGKNANAEVPSTTEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGLRKQQAHESSRPLSIERPGAVHPWVSAQLRNSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRANKLPSKQRYVQAVMQRGRTCVRPACAPVLSVVPAVSDLELSETETKSQRKAGGGSAPPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD
Protein: Transcription factor MYC1 (SlMYC1) (A0A060KY90)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Transcriptional activator that binds to the G-box motif (5'-AACGTG-3') found in a number of promoters of jasmonate-induced genes. Transcription activator involved in the transcriptional regulation of terpene biosynthesis in glandular trichomes. Binds to the promoter of the linalool synthase TPS5 and promotes TPS5 gene transactivation. Acts synergistically with EOT1 in the transactivation of TPS5. Involved in type VI glandular trichome development. Involved in the activation of terpene synthases required for volatile mono- and sesquiterpenes synthesis by the glandular cells of type VI trichomes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- Protein JAZ7
- Tify domain-containing protein
- Protein TIFY
- Protein TIFY
- Protein TIFY
- Protein TIFY
- Protein TIFY
- Protein TIFY
- Mitogen-activated protein kinase
- Mitogen-activated protein kinase
Sequence:
MTDYRLWSNTNTTNTCDDTMMMDSFLSSDPSSFWPASTPNRPTPVNGVGETMPFFNQESLQQRLQALIDGARESWAYAIFWQSSVVDFASQTVLGWGDGYYKGEEDKNKRRGSSSSAANFVAEQEHRKKVLRELNSLISGVQASAGNGTDDAVDEEVTDTEWFFLISMTQSFVNGNGLPGLAMYSSSPIWVTGTEKLAASQCERARQAQGFGLQTIVCIPSANGVVELGSTELIFQSSDLMNKVKYLFNFNIDMGSVTGSGSGSGSCAVHPEPDPSALWLTDPSSSVVEPKDSLIHSSSRDVQLVYGNENSENQQQHCQGFFTKELNFSGYGFDGSSNRNKTGISCKPESREILNFGDSSKRFSGQSQLGPGPGLMEENKNKNKNKKRSLGSRGNNEEGMLSFVSGVILPTSTMGKSGDSDHSDLEASVVKEAVVEPEKKPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAIAYINELKSKVQNSDLDKEELRSQIECLRKELTNKGSSNYSASPPLNQDVKIVDMDIDVKVIGWDAMIRIQCSKKNHPAARLMAALKDLDLDVHHASVSVVNDLMIQQATVKMGSRLYAQEQLRIALTSKIAESR
Protein: Rac family small GTPase 3b (Ras-related C3 botulinum toxin substrate 3b) (Zgc:175209 protein) (A9JRY8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- BAR/IMD domain-containing adaptor protein 2b.
- BAR/IMD domain-containing adaptor protein 2a.
- Rho guanine nucleotide exchange factor
- Spermatogenesis-associated 13.
- IQ motif-containing GTPase-activating protein 2
- Guanine nucleotide exchange factor VAV2 isoform X3
- Si:ch73-383g2.1.
- Guanine nucleotide exchange factor VAV3b isoform X2
- IQ motif-containing GTPase-activating protein 3.
- IQ motif-containing GTPase-activating protein 1.
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIERLRDKKLSPITYPQGLAMAREIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRGKRCTLF
Protein: SMAD specific E3 ubiquitin protein ligase 2 (A0A8I5ZTH9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLQ
Protein: Apurinic-apyrimidinic endonuclease 1 (AP endonuclease 1) (EC 3.1.21.-) (P22936)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA. APN1 accounts for > 97% of both apurinic/apyrimidinic (AP) endonuclease and DNA 3'-repair diesterase activities.
Subcellular location: Nucleus.
Interaction partners:
- DNA-
- Endonuclease III homolog 2 lyase 2)
- Endonuclease III homolog 1 lyase 1)
- Uracil-DNA glycosylase
- Tyrosyl-DNA phosphodiesterase 1
- DNA repair protein RAD1
- N-glycosylase/DNA lyase
- DNA polymerase zeta catalytic subunit
- DNA repair protein RAD10
- DNA repair protein RAD14
Sequence:
MPSTPSFVRSAVSKYKFGAHMSGAGGISNSVTNAFNTGCNSFAMFLKSPRKWVSPQYTQEEIDKFKKNCATYNYNPLTDVLPHGQYFINLANPDREKAEKSYESFMDDLNRCEQLGIGLYNLHPGSTLKGDHQLQLKQLASYLNKAIKETKFVKIVLENMAGTGNLVGSSLVDLKEVIGMIEDKSRIGVCIDTCHTFAAGYDISTTETFNNFWKEFNDVIGFKYLSAVHLNDSKAPLGANRDLHERLGQGYLGIDVFRMIAHSEYLQGIPIVLETPYENDEGYGNEIKLMEWLESKSESELLEDKEYKEKNDTLQKLGAKSRKEQLDKFEVKQKKRAGGTKRKKATAEPSDNDILSQMTKKRKTKKE
Protein: Reticulocalbin-1 (Q15293)
Organism: Homo sapiens (Human)
Function: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
Subcellular location: Endoplasmic reticulum lumen.
Interaction partners:
- ER lumen protein-retaining receptor 1
- Outer kinetochore KNL1 complex subunit ZWINT
Sequence:
MARGGRGRRLGLALGLLLALVLAPRVLRAKPTVRKERVVRPDSELGERPPEDNQSFQYDHEAFLGKEDSKTFDQLTPDESKERLGKIVDRIDNDGDGFVTTEELKTWIKRVQKRYIFDNVAKVWKDYDRDKDDKISWEEYKQATYGYYLGNPAEFHDSSDHHTFKKMLPRDERRFKAADLNGDLTATREEFTAFLHPEEFEHMKEIVVLETLEDIDKNGDGFVDQDEYIADMFSHEENGPEPDWVLSEREQFNEFRDLNKDGKLDKDEIRHWILPQDYDHAQAEARHLVYESDKNKDEKLTKEEILENWNMFVGSQATNYGEDLTKNHDEL
Protein: UV excision repair protein rhp23 (RAD23 homolog) (O74803)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:11788722}.
Interaction partners:
- DNA repair protein rhp41
- 26S proteasome regulatory subunit rpn10
- 26S proteasome regulatory subunit rpn1
- Peptide-N
- Ubiquitin conjugation factor E4
- Polyubiquitin
- mRNA export factor elf1
- 26S proteasome regulatory subunit rpn11
- DNA repair protein rad14
- Elongation factor 3
Sequence:
MNLTFKNLQQQKFVISDVSADTKISELKEKIQTQQNYEVERQKLIYSGRILADDKTVGEYNIKEQDFIVCMVSRPKTSTSTPKSAASPAPNPPASVPEKKVEAPSSTVAESTSTTQTVAAAAPSNPDTTATSEAPIDANTLAVGAQRNVAVENMVEMGYERSEVERAMRAAFNNPDRAVEYLLTGIPEDILNRQREESAAALAAQQQQSEALAPTSTGQPANLFEQAALSENENQEQPSNTVGDDPLGFLRSIPQFQQLRQIVQQNPQMLETILQQIGQGDPALAQAITQNPEAFLQLLAEGAEGESALPSGGIQIQITQEESESIDRLCQLGFDRNIVIQAYLACDKNEELAANYLFEHGHESEDEP
Protein: DNA gyrase subunit A (EC 5.6.2.2) (C5C7X9)
Organism: Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / CCM 169 / CCUG 5858 / IAM 1056 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
Function: A type II topoisomerase that negatively supercoils DNA in an ATP-dependent manner. About 140 bp of DNA wraps around gyrase in the presence or absence of ATP, when ATP is added negative supercoils are made.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:276855}.
Interaction partners:
- DNA gyrase subunit B
- DNA topoisomerase
- Transmembrane domain of uncharacterized function
- Abortive phage infection protein C-terminal domain-containing protein
- DNA-directed RNA polymerase subunit beta
- Protein RecA
Sequence:
MSDETTPQTPDEPVEGAPIPGTPQTGLDIEVEHYVLPEGAADKVEPVDLESEMKRSYLDYAMAVIVGRALPDVRDGLKPVHRRVLYAMYDGGYRPDRAFNKSARVVGDVMGNYHPHGDTAIYDALVRLIQDWVQRYPLALGQGNFGSPGNDGAAAQRYTETKMAPLAMEMVRDIDEDTVDMQDNYDGKQQEPVVLPARYPNLLVNGSSGIAVGMATNIPPHNMREVAAGVQWYLEHPEATREELLEALLARVHGPDFPTGAQILGRKGIEEVYRTGRGPITMRAVVNVEEIQGRTCLVVTELPYMTNPDNLAAKIAEMVRDGKISGIADMRDETSGRTGQRLVIVLKRDAVAKVVLNNLYKHTELQSNFSANMLALVDGVPRTLSLDGFVHHWVKHQIDVIVRRTAFRKRKAEERAHILRGLLKALDMLDEVIATIRRSASADVAREALKELLDIDDVQAQAILQMQLRQLAALESQKIQDEYDDLMAKIAEYNRILESPQRQREVISEELAEIVAKHGDDRRTEIMAGFDGDMSIEDLIPEEEMVVSITRGGYVKRTRIDQYRSQARGGKGVRGATLRGDDVVEHFLTVSTHHWLLFFTNFGRVYRIKTYELLEAGRDAKGQHVANLLAFQPDERIAQIQPLVDYGRAPYLVLATRGGLVKKTPLLDYDTNRTAGLIAIKLREGDELVSARVVSPDDDLILISHKGQSLRFTATDEALRPMGRATSGVTGMKFRDDDSLLTMDVVEEDGYVFTVTDGGFAKRTHVDEYRLQNRGGLGIKVAKLVDDRGELAGGLVVREDQEVLVVMASGKVVRSAVAGVPAKGRDTMGVIFAKPDKRDRIVAVTLNNEQEMEAKADAEAEAGPDVPLDADIDPTDPVAAPEDALTQDAGEGADGGEQ
Protein: Probable pectinesterase/pectinesterase inhibitor 12 [Includes: Pectinesterase inhibitor 12 (Pectin methylesterase inhibitor 12); Pectinesterase 12 (PE 12) (EC 3.1.1.11) (Pectin methylesterase 12) (AtPME12)] (O48711)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular location: Secreted, cell wall {ECO:0000250}.
Interaction partners:
- Methyl-coenzyme M reductase II subunit gamma, putative
Sequence:
MALSSFNLSSLLFLLFFTPSVFSYSYQPSLNPHETSATSFCKNTPYPDACFTSLKLSISINISPNILSFLLQTLQTALSEAGKLTDLLSGAGVSNNLVEGQRGSLQDCKDLHHITSSFLKRSISKIQDGVNDSRKLADARAYLSAALTNKITCLEGLESASGPLKPKLVTSFTTTYKHISNSLSALPKQRRTTNPKTGGNTKNRRLLGLFPDWVYKKDHRFLEDSSDGYDEYDPSESLVVAADGTGNFSTINEAISFAPNMSNDRVLIYVKEGVYDENIDIPIYKTNIVLIGDGSDVTFITGNRSVGDGWTTFRSATLAVSGEGFLARDIMITNTAGPEKHQAVALRVNADFVALYRCVIDGYQDTLYTHSFRQFYRECDIYGTIDYIFGNAAVVFQGCNIVSKLPMPGQFTVITAQSRDTQDEDTGISMQNCSILASEDLFNSSNKVKSYLGRPWREFSRTVVMESYIDEFIDGSGWSKWNGGEALDTLYYGEYNNNGPGSETVKRVNWPGFHIMGYEDAFNFTATEFITGDGWLGSTSFPYDNGI
Protein: Golgi pH regulator (LD13915p) (Q3ZAN1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Oxysterol-binding protein
Sequence:
MAFLGDCVIVFVSQMIFFAGGWLFFNKELFKHYEIRHISVQLIFSSTFALSITMFELIIFEIIDVLESSSRYFHWRLGLTLLLFMTTAVIPIYICYSVIHSISFFSDKWVRILTTFCWFIFIYGLWRIGDPFPLLSASHGIFTIEQGVSRISVIGVTVMAILSGFGAVNYPYTSMSYFIKPVSRNDIICFERRLALTVEMLSAKKRKIAMAIYNHNKLNPSKPRIWDMLASAVQRNTNSGEDINQLKQEVYGLEELLRSVFLELSSLKNMEERQRWSQTLKGKYFNVLGHFFSVYCVYKIFMCCINIIFDRVGRKDPVTRGLEIAIHWCGFNIDFAFWNQHISFLLVGCIVITSIRGLLLTLTKFFYRISSSKSSNIIVLILGQIMGMYFCSSVLLMRMNMPAEYRVIITEVLGNLHFNFYHRWFDVIFLVSALTTIIVLYLSRKPVRVDDSDLN
Protein: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) (Renal carcinoma antigen NY-REN-4) (P56181)
Organism: Homo sapiens (Human)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase 1 subunit C1, mitochondrial
Sequence:
MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKKPAPVPAEPFDNTTYKNLQHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH
Protein: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Q9CQ62)
Organism: Mus musculus (Mouse)
Function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q16698}.
Interaction partners:
- Enoyl-CoA delta isomerase 1, mitochondrial
- Peroxisomal bifunctional enzyme
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Enoyl-CoA delta isomerase 2
- Delta
- 3-ketoacyl-CoA thiolase, mitochondrial
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Trifunctional enzyme subunit beta, mitochondrial
Sequence:
MALLGRAFFAGVSRLPCDPGPQRFFSFGTKTLYQSKDAPQSKFFQPVLKPMLPPDAFQGKVAFITGGGTGLGKAMTTFLSTLGAQCVIASRNIDVLKATAEEISSKTGNKVHAIRCDVRDPDMVHNTVLELIKVAGHPDVVINNAAGNFISPSERLTPNGWKTITDIVLNGTAYVTLEIGKQLIKAQKGAAFLAITTIYAESGSGFVMPSSSAKSGVEAMNKSLAAEWGRYGMRFNIIQPGPIKTKGAFSRLDPTGRFEKEMIDRIPCGRLGTMEELANLATFLCSDYASWINGAVIRFDGGEEVFLSGEFNSLKKVTKEEWDIIEGLIRKTKGS
Protein: Alpha-L-arabinofuranosidase axhA-2 (EC 3.2.1.55) (Arabinoxylan arabinofuranohydrolase axhA-2) (Q5AUX2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan (By similarity).
Subcellular location: Secreted.
Interaction partners:
- Endo-1,4-beta-xylanase C
Sequence:
MRNLSTWPTFAALLWSAPRVLAQCGLPSTYSWTSTGPLAEPKDGWASLKDFTAVPYNGQYLVYATYHDTGTSWGSMNFGLFSNWSDMATASQNAMTQSTVAPTLFYFEPKDVWILAYQWGPTAFSYLTSSDPTDANGWSSPQPLFSGSISDSDTGVIDQTVIGDSTTMYLFFAGDNGRIYRASMPIDQFPGDFGTESEIILSDERNNLFEAVQVYTVSGQSKDTYLMIVEAIGAQGRYFRSFTADSLGGSWTPQAATESAPFAGKANSGATWTDDISHGDLVRSTPDQTMSIDPCNLQLLYQGRDPSLNPGYDLLPYRPGLLTLK