wanglab/gogpt-training-data huggingface dataset:
Protein: I/LWEQ domain-containing protein (G4S9F5)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MRRPTVVSDVHVFHYYTGTLRPPVRPTQRNGSVSWSSTSSTTSSTSLNRRHYKGAKTISAECDEPQVQERVIQSATKCAFATSQLVACARVVAPTIDNNACQQQLSTAATEVTQSVNNLLHDAEHAVYQQSSLTDIHEAARQVTSALDSLLEHAKCSPKTQTTRREEEEMYNEVLRRTNRMVVHQGPSEDLTREARKVVRHSQLLTEQFQHEAHQRPEHRERLLDAAAKVAHATSEMILATEQAESQPRQVETEYALRTAAERLGQVTNETTQEQQEQHIMQRLEQAAKQTAYDATQTISAANSAKDVIESRSYKENLVYESTQTAGHLPNLITSIRESQKVDNTPGEKFKAQSRLIRDSYKVLETSVRLFETARTAVPMVSDSHLASSLDQSANRLGTSLADLRTSVNDAQQLNFSQQLLYSEELIKELDDQLVNTQKRAIARELPPIQNATSFSVSSKLMATTSNVGSGVAQLITAAATSNDDKYVGTSAVELAQGLRDFTDAITEIVTVRTDIQLDKLIVSARSVVHESGRVFDRVREKSAPTVLTDAAMNVSTSLKQVISCLPDTKHIEKAIHEIQTAHTSANIRPMEVRQAANKFIEATSQLVVTIGSPDSREAVDIFVRAYCDLHGSVVAQLQRQSNMNNVKTAIIDRLEEAQRGSIGVLETLRQAGNPSDHTLSQQFTSKTRELATTVNQLVELSGMDGGESRWQRECDAALRRIQAVYHVTQHANVPLNDNGYFASLQSVSDGSRRLGEAMTGMARHAKGNDTEGFCTSVRDSADALCSLAESASHSAYLVGISHPASSPGRAALIDSSEVARSVESINASCQRVESRQLNREELMSDISSITKQSSSLAQLCRIASEKTQNPNVKKHLVGCAMGVASKTSSLVTAFKDLDRMPDAESRCTSSASELRQVALQLLHFADKPDFAAIQGSISTEGHSAQQPILQSSREMLDSSAQMIQTAKSWASAPQDEATWQRMAVNSRQVSDSIMRLVNAIHEAAPGQMELEAAIGRLSALSGQIERSAMDCYASGNVQKHGANAERQLLQQVQHIASQLEDKVDDLHNAAVEHGERLPKVVQLHCQMVEDLADAACCAAGMTVDSNQQTELFDKCKTVVEAELAMMVASRESGGNPNAVHAHANVKDAAGQLKHAIGDMRQTIAKVSSEQGAVQGMVDTISSSIAHTDVAVSSAHPGSSFADAQTRMTAYLEDIRRTAIEMPTLNTTDLGAASLNLSEKYRLVAGDVRQAAGMLPEADIGQRLKLAVQKLGTSCIETVTVAGGKRAHPEDERIQRQLSSQAGTVVERVEQVLAALHSASRGTQACINAANTVSGIIGDLDTTIMFATSGSLNSSDDRKFPSHKEAIVKTAKALVEDTKALVAGAASNQEQLAVAAQNAVRTIVNLSDAVKTGAVSLSSENSETQVLVIHAVRDVAAALTSLIQATKNASGLSLQHPAMGHLKDAAKVMVSNVARLLKTVATVEEKNQQGTRAVEAAVDAIGFEMKQFEHDLNEGAAIPTDFRPEHLQQTAEHVSEITKRVMQGADAPQSEEEIIGVANLSRSAVRSLLAVVRTISNDADTAPQRYAVLDSGRDVANNVKSLLVSLHTQMVRNPGQEESRRLLLEASKGVSSALSHLVGLCNEMTGLPHNHEMESAAAQAENELLGAASSIEAASAKLAELRPRQIVQENTQEIVETEFDDNIIISAKGILHAVHTLMRSASNAQRELAMQGRAAAGGTGTYQWSEGLISAARVVVASVHKLCDAANTLMKGQTTEERLISAAKQVSSSTAQLLVACNVRADPDSQANRRLQAAGQAVRNAAERLVQSAQQEMIARDDRNIAISDRLVNGIAQVMDAQEEVLRKERELGEARHKLAHLNKARYERDGEEA
Protein: Protein CHLOROPLAST ENHANCING STRESS TOLERANCE, chloroplastic (OsCEST) (Q5VQK9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in light-induced chloroplast development and growth. Involved in the plant response to abiotic and photooxidative stresses. May be involved in the suppression of photooxidative damage.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000305|PubMed:20876334}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Os04g0589400 protein
Sequence:
MALLSPPSPPPPLPPLRRRPASPTLLAVATRPSSLLSLPHCHCGLPLPSTANARAYSRSSRRRRRVAASLGQDEPGVSDTAVAPEGEGDSEPPASSDGAAGDIAASAEQPEASPEDLEDIRQVKRVLELLQKNRDMTFGEVKLTIMIEDPRDIERKRLLGIEDPDEITRDDLADALVEVNEGRIPENRVALQLLAKEMTEWPDLEMEAPKKKSKPGKSVYAKATDTGIDPETAAKRLNIDWDSAADLDDEEEEDDETEVPSAVGYSALYLLTAFPVIIGISVVLILFYNSLQ
Protein: NPC1-like intracellular cholesterol transporter 1 (Niemann-Pick C1-like protein 1) (Npc1l1) (Q6T3U4)
Organism: Mus musculus (Mouse)
Function: Plays a major role in cholesterol homeostasis. Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation. May be involved in caveolin trafficking from the plasma membrane. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (By similarity).
Subcellular location: Apical cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q6T3U3}; Multi-pass membrane protein. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein.
Interaction partners:
- NPC intracellular cholesterol transporter 2
- ATP-binding cassette sub-family G member 5
- Sterol regulatory element-binding protein 2
- ATP-binding cassette sub-family G member 8
- Scavenger receptor class B member 1
- Sterol regulatory element-binding protein 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Cytochrome P450 7A1
- Phospholipid-transporting ATPase ABCA1
- Apolipoprotein B-100
Sequence:
MAAAWQGWLLWALLLNSAQGELYTPTHKAGFCTFYEECGKNPELSGGLTSLSNISCLSNTPARHVTGDHLALLQRVCPRLYNGPNDTYACCSTKQLVSLDSSLSITKALLTRCPACSENFVSIHCHNTCSPDQSLFINVTRVVQRDPGQLPAVVAYEAFYQRSFAEKAYESCSRVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALADGMKPLDGKITPCNESQGEDSAACSCQDCAASCPVIPPPPALRPSFYMGRMPGWLALIIIFTAVFVLLSVVLVYLRVASNRNKNKTAGSQEAPNLPRKRRFSPHTVLGRFFESWGTRVASWPLTVLALSFIVVIALSVGLTFIELTTDPVELWSAPKSQARKEKAFHDEHFGPFFRTNQIFVTAKNRSSYKYDSLLLGPKNFSGILSLDLLQELLELQERLRHLQVWSHEAQRNISLQDICYAPLNPHNTSLTDCCVNSLLQYFQNNHTLLLLTANQTLNGQTSLVDWKDHFLYCANAPLTYKDGTALALSCIADYGAPVFPFLAVGGYQGTDYSEAEALIITFSINNYPADDPRMAHAKLWEEAFLKEMQSFQRSTADKFQIAFSAERSLEDEINRTTIQDLPVFAISYLIVFLYISLALGSYSRWSRVAVDSKATLGLGGVAVVLGAVVAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKRQEASRPDVVCCFSSRNLPPPKQKEGLLLCFFRKIYTPFLLHRFIRPVVLLLFLVLFGANLYLMCNISVGLDQDLALPKDSYLIDYFLFLNRYLEVGPPVYFDTTSGYNFSTEAGMNAICSSAGCESFSLTQKIQYASEFPNQSYVAIAASSWVDDFIDWLTPSSSCCRIYTRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTTEQFHKYLPWFLNDTPNIRCPKGGLAAYRTSVNLSSDGQIIASQFMAYHKPLRNSQDFTEALRASRLLAANITAELRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATIFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVLEEKLATEAAMVSEPSCPQYPFPADANTSDYVNYGFNPEFIPEINAASSSLPKSDQKF
Protein: ADF-H domain-containing protein (Q75JY8)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Adenylyl cyclase-associated protein
Sequence:
MVLQFVDDSSCKSAIADLRNDSTSTDWVLLSFESPKSEKIKLVGSGSGGVAELVEHLQDDLVGFALVRKIDKIDDSETVKFAFINFIGEKVGIFQKGKISVTIGGVKDFLGSFQCDFLITSKNEISDEIVLNKIQDISGTGSKVLDENGAKTGASKSTTSPTNSFRKSTYGSVSSPSSSNKDSIKLGDEPAIREALKEFRSDENDIDWVLFGYEGGNSNTIILLGKGNGGVNELISNLQDNLVGYGLVRIVEKIDNSDTIKFAYINWIGEEIPRMLRARLGTHTGFVNQLVTPYHVDIKCTVKSEISKEIVEETVAKASGKASMVLSDDAQSRGSGGRMTSSYSSSSASTQGSNTTGKTFAGAGSKFTTPSAVPKSSGSTLGFDDEQQVRDTIKDVRSDSTDTNWCLVGYKNDTTLTVIAKGNGGVDELVGHLNSKIVAYGLVREVERFDLSDTIKFAFIDFVGEDINRMFRAKLGTHSGTVKQLFHPYHVDLHVSSPSELSSEIVTKTITQNSGTSSRVKA
Protein: Growth factor independent 1B (Potential regulator of CDKN1A, translocated in CML), isoform CRA_a (Growth factor independent 1B transcriptional repressor) (A0A024R8F3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPRSFLVKSKKAHTYHQPRVQEDEPLWPPALTPVPRDQAPSNSPVLSTLFPNQCLDWTNLKREPELEQDQNLARMAPAPEGPIVLSRPQDGDSPLSDSPPFYKPSFSWDTLATTYGHSYRQAPSTMQSAFLEHSVSLYGSPLVPSTEPALDFSLRYSPGMDAYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDICGKTFGHAVSLEQHTHVHSQGIPAGSSPEPAPDPPGPHFLRQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK
Protein: Focal adhesion kinase homolog DFak56 (Q9U531)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNTAGATSQPPPTKNEINSEEYLIHVHMPNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRTPSIQRYACRMLNMITKEVIWLARSTSMQKVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCFYYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVGPHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRSLITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKREQRKVASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYIIAQNPAVLAKLMMENQKRGINPAAYTTPASGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRQRSCSIPQGSLNDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPPNRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPAQALKEVQMAHQVLSKDMLELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVVDSIRQRYQHLFPPSATKETSCSSSFESTSGSIVTEPVNDLGGYIKTSTSGDLLQNTGIYDNDLHHSFNSQLQLQNPKAGIDLSGGGSLQRGMSLGLDTTRSTNEPLRIVEETLGSPGEHMYCNTSALHGHA
Protein: Putative pectinesterase (SKU5 similar 9) (Q8VYB3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Glutaredoxin family protein
- non-specific serine/threonine protein kinase
- UDP-glycosyltransferase 79B5
- Cytochrome P450 71B22
- Probable acyl-activating enzyme 12, peroxisomal
- UDP-glycosyltransferase 72B2
- Monothiol glutaredoxin-S9
- NAC domain containing protein 63
- Berberine bridge enzyme-like 5
- Glutathione S-transferase U12
Sequence:
MCWWLNGAVWTMMMMTISIISFVQADDPYRFFDWRVTYGNISPLGIPQRGILINGQYPGPDIYSVTNDNLIINVHNDLDEPFLLSWNGVQLRKNSYQDGVYGTTCPIPPGKNYTYAIQVKDQIGSFFYFPSLAVHKAAGGFGGFRILSRPRIPVPFPEPAGDFTFLIGDWFKHDHKVLKAILDRGHKLPLPQGVLINGQGVSYMSSITVHKGKTYRFRISNVGLQHTLNFRIQGHQMKLVEVEGTHTVQSMYTSLDIHVGQSYSVLVTMDQPDQDYDIVVSTKFVAKKLLVSSTIHYSNSRHSHSSSANSVHVQQPADELDWSIKQARSIRTNLTASGPRPNPQGSYHYGRIKISRTLILESSAALVKRKQRYAINGVSFVPGDTPLKLADYFKIKGVFKMGSIPDKPRRGRGMRMETSVMGAHHRDFLEIIFQNREKIVQSYHLDGYSFWVVGTDRGTWSKASRREYNLRDAISRSTTQVYPESWTAVYVALDNVGMWNLRSEYWARQYLGQQFYLRVYSPTHSLRDEYLLPKNALLCGRASNKHTTP
Protein: Exportin-4 (Q0VG75)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVNNEQRQHAEHIFLSFRKSKSPFAVCKHILETSKVDYVLFQAATAIMEAVVREWILLEKGSIESLRTFLLTYVLQRPNLQKYVREQILLAVAVIVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSILTALLSEFSSSSKTSNIGLSMEFHGNCKRVFQEEDLRQIFMLTVEVLQEFSRRENLNAQMSSVFQRYLALANQVLSWNFLPPNLGRHYIAMFESSQNVLLKPTESWRETLLDSRVMELFFTVHRKIREDSDMAQDSLQCLAQLASLHGPIFPDEGSQVDYLAHFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVLTAIPSELFSSFVNCLTHLTCSFGRSAALEEVLDKDDMVYMEAYDKLLESWLTLVQDDKHFHKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISELQEDDRDQFSDQLASVGMLGRIAAEHCIPLLTSLLEERVTRLHGQLQRHQQQLLASPGSSTVDNKMLDDLYEDIHWLILVTGYLLADDTQGETPLIPPEIMEYSIKHSSEVDINTTLQILGSPGEKASSIPGYNRTDSVIRLLSAILRVSEVESRAIRADLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQISLPFSTAFGADTEGSQWIIGYLLQKVISNLSVWSSEQDLANDTVQLLVTLVERRERANLVIQCENWWNLAKQFASRSPPLNFLSSPVQRTLMKALVLGGFAHMDTETKQQYWTEVLQPLQQRFLRVINQENFQQMCQQEEVKQEITATLEALCGIAEATQIDNVAILFNFLMDFLTNCIGLMEVYKNTPETVNLIIEVFVEVAHKQICYLGESKAMNLYEACLTLLQVYSKNNLGRQRIDVTAEEEQYQDLLLIMELLTNLLSKEFIDFSDTDEVFRGHEPGQAANRSVSAADVVLYGVNLILPLMSQDLLKFPTLCNQYYKLITFICEIFPEKIPQLPEDLFKSLMYSLELGMTSMSSEVCQLCLEALTPLAEQCAKAQETDSPLFLATRHFLKLVFDMLVLQKHNTEMTTAAGEAFYTLVCLHQAEYSELVETLLSSQQDPVIYQRLADAFNKLTASSTPPTLDRKQKMAFLKSLEEFMANVGGLLCVK
Protein: ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) (Q9UJY4)
Organism: Homo sapiens (Human)
Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775, ECO:0000269|PubMed:28289207}; Peripheral membrane protein {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775}. Endosome membrane {ECO:0000269|PubMed:15039775}; Peripheral membrane protein {ECO:0000269|PubMed:15039775}. Early endosome membrane {ECO:0000269|PubMed:11950392}; Peripheral membrane protein {ECO:0000305}.
Interaction partners:
- ADP-ribosylation factor-binding protein GGA1
- ADP-ribosylation factor-binding protein GGA3
- Cation-independent mannose-6-phosphate receptor
- Rab GTPase-binding effector protein 1
- Sortilin-related receptor
- Sortilin
- Clathrin interactor 1
- Cation-dependent mannose-6-phosphate receptor
- Clathrin heavy chain 1
- Beta-secretase 1
Sequence:
MAATAVAAAVAGTESAQGPPGPAASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMCMNHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQGIIKQDPKLPVDKILPPPSPWPKSSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSKRVSAVEEVRSHVKVLQEMLSMYRRPGQAPPDQEALQVVYERCEKLRPTLFRLASDTTDDDDALAEILQANDLLTQGVLLYKQVMEGRVTFGNRVTSSLGDIPVSRVFQNPAGCMKTCPLIDLEVDNGPAQMGTVVPSLLHQDLAALGISDAPVTGMVSGQNCCEEKRNPSSSTLPGGGVQNPSADRNLLDLLSAQPAPCPLNYVSQKSVPKEVPPGTKSSPGWSWEAGPLAPSPSSQNTPLAQVFVPLESVKPSSLPPLIVYDRNGFRILLHFSQTGAPGHPEVQVLLLTMMSTAPQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLAVLGAA
Protein: Uncharacterized protein (Q57W64)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQVSPRVPKVKAKTPYDLPERVRWYHILWEMRKGEFRRSYISMQRRHWRIFLKYESHLIYERAVMGLLAATVIYALSNLNIVKAVVRLPTEDINELLKEDVWQGYRNEVNQRKEHANKMLEESAFIRDKNKPFSS
Protein: Uncharacterized protein (Q389P0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cdc23 domain-containing protein
- Cell division cycle protein 16, putative
- Anaphase-promoting complex subunit 2
- Cyclosome subunit 1, putative
- Anaphase-promoting complex subunit 11
- Rev7, putative
- Uncharacterized protein
- Anaphase-promoting complex subunit 10
- Dynein heavy chain region D6 P-loop domain-containing protein
- Ubiquitin-conjugating enzyme E2, putative
Sequence:
MRHWAQAEYDSTASEFRSKRHAQLCSSTPLQKLSTNNPRMMSRSPVEDETPPVRLSRHIPQREGMDMVVSAYNLTTSPTPPLVLSPGVGASGVLSLPHSAGASFSSHFSESIVSDDSSYVTSMYNEVLAEQLSSESTQKQRKIGGEVLGFNNADSLRSLVAPNLASSGGGRTISGSVSPTEDDGPKHCEYSANTNSTRTAVAPLFAHAPTGRAMLLKKIKPGKAPTQRVMFTTPERTLDAPEFPSDVSQLLHWGTNNKLIIGLKNGLHGWDAETAKASQIVCLEEHATIRAVHWLDGCTCVALALDEGPVAIYDCHQVGFLRTLQTCLSGKARPSYIAANGPLLSVGLNSGTGGVYVFDLRTKNALISVYEGHANGVASLNYCTKEPFYLAAGYANGAVRVWDARRANCPRYVFDSVHSGPVTAIHWDPDKRSKMYTGGQDGMMCYVDTNAPTTNVPSAPRTEDEGFTGGCHFITRAINTMHPISGIVAPPDVGELATTHRGKGQIQLRQSSNLHLIGALGSPNTSSDITCPTIAPDMQRICTAQDELLKFWRVFWPSVSPQRAECSTPPPVSLLEDELR
Protein: Kallikrein-7 (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (Thymopsin) (Q91VE3)
Organism: Mus musculus (Mouse)
Function: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Cadherin-1
- Desmocollin-1
- Corneodesmosin
- Filaggrin
- Desmoglein-1-alpha
- Serine peptidase inhibitor, Kazal type 5
- Desmoglein-1-beta
Sequence:
MGVWLLSLITVLLSLALETAGQGERIIDGYKCKEGSHPWQVALLKGNQLHCGGVLVDKYWVLTAAHCKMGQYQVQLGSDKIGDQSAQKIKATKSFRHPGYSTKTHVNDIMLVRLDEPVKMSSKVEAVQLPEHCEPPGTSCTVSGWGTTTSPDVTFPSDLMCSDVKLISSRECKKVYKDLLGKTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQGLVSWGTYPCGQPNDPGVYTQVCKYKRWVMETMKTHR
Protein: Major prion protein (PrP) (PrP27-30) (PrP33-35C) (CD antigen CD230) (P04273)
Organism: Mesocricetus auratus (Golden hamster)
Function: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P04156}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P04156}. Golgi apparatus {ECO:0000250|UniProtKB:P04925}. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis. {ECO:0000250|UniProtKB:P04156}.
Interaction partners:
- Neural cell adhesion molecule 1 isoform X5
- Amyloid-beta A4 protein
- Stress-induced-phosphoprotein 1
- Tyrosine-protein kinase
- Neural cell adhesion molecule 2
- Endoplasmic reticulum chaperone BiP
- Glycogen synthase kinase-3 beta
- 26S proteasome non-ATPase regulatory subunit 14
- Caveolin
- Casein kinase II subunit alpha
Sequence:
MANLSYWLLALFVAMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGTWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHNQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPMMHFGNDWEDRYYRENMNRYPNQVYYRPVDQYNNQNNFVHDCVNITIKQHTVTTTTKGENFTETDIKIMERVVEQMCTTQYQKESQAYYDGRRSSAVLFSSPPVILLISFLIFLMVG
Protein: Pcr3 (Type III secretion protein, YscX family) (Type III secretion system protein PscX) (Yop proteins translocation protein X) (YscX family type III secretion protein) (O30534)
Organism: Pseudomonas aeruginosa
Interaction partners:
Sequence:
MSRVGAWHIGIERLDLAHAEPFAPPLPERHLLAPDGRPVETHVASLYPAQQAQQRLFDYARPQLEFHGLLRPGDFRQALRDLRLALTLPRQPALQAAACLLGERDEDERLLQMALNLLHKV
Protein: PAT complex subunit CCDC47 (Coiled-coil domain-containing protein 47) (Q9VQR9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Rough endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00034697}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00034697}.
Interaction partners:
- Calcium load-activated calcium channel
- Nicalin
- BOS complex subunit TMEM147
- DSec61alpha
- Protein Asterix
- Protein transport protein Sec61 subunit beta
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL20
- Large ribosomal subunit protein uL3
Sequence:
MRPVFAFLLLALICFASTKSESDFEEDDSDDFAEFDDGNFYAEPAAKNADSFSGGAGSSHGESRDDPPAKEPRKQAQNQESDEEDGLVEDDDEFEHFQDEEEFEGYDGGDSKDPPIDQKVEPKLNIPNIPLHFRTHWDSYWMEMLMVAGLLAYFANFFAGKAKNARLAQLWFSTHRALLDENFALVGDDGKAENENPGLIKESESLYTLWCSGRTCCEGMLVELKMIKRQDLVSLVAGLMRPQLDQAHIKIELTRGVMDAFVFAVGTKKTITKLFKEYTDLSKFCSLVGKPEDRYNVPTGFGVLSEIPEATSAILESRIITALNKYQSYIDYLHISDQFSGPIQQEEGGTLKQPETKAVLLAGFNLPKHAEMETIKPLLLLIFYLMERLKTYRMSKEGKAKSDKNRQRVEEEFLKSTHAARAEAAAQRREDKRKQEKERILADEDPEKQRRWEAKEQKRQAKRNAPKMKRLAVKSL
Protein: Basic helix-loop-helix protein-like (Q5SMX2)
Organism: Oryza sativa subsp. japonica (Rice)
Interaction partners:
Sequence:
MDSSSWIHGYTNANATGANSGFMCGYAASPVEFPQQQQLISMQMGMDDESAVYDGASMVGDLLMASSSAHHAGAGSFQYSSSTTSSSASFRSASVSCNPESSAAAAPELPAATGGAFSRYARHLRPRRPPKPGACGQRMFKTAMSVLANMHVAATYRRQYYYQQAAAAAAAEAAPAPPSDNQLQHMISERKRREKLNDSFVALKAVLPTGSKKDKASILIRAREHIKSLESKLSELEEKNRELEARLASRPAAKNDKGETAAAEAGDETKREDLVEIEVTTTSGGSGAAAAAATGGDQETCCTLNVDLRGGGGGGMSTTDVVLRTLQCLREQIGDGASLVAMSTSAGSGGRPPSANLTLQLKSPTYGRCSYKYEFTLFLVNRQKPTIKHIRYGSRKISMSLSMDDVTMISPR
Protein: BCL2 like 12 (Q9D3J3)
Organism: Mus musculus (Mouse)
Interaction partners:
- Apoptosis regulator Bcl-2
Sequence:
MAGSEELGLREDTLKVLTAFLKRGEVAGSPVPTPPRSPAQEETTDFLSRLRRCLPCPLGRGAPPTESSRPHFLPLRPCYGSEPGPASSEFYALVAQRLEQLVQEQLKSPPSSEFQGPPPTEKEALLRRLVALLEEEAEVINQKLASDPALHRKLARLSAGSFARLVELFSSRESSSSPNCSSPSLPCPGPPPPSPDPLARLALAMELSRRVAGLGGPLANLSVEHVHSFLPWVQAHGGWAGILASSPVDLNLPLD
Protein: Uncharacterized protein (Q38EN9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSPSAREVEEVVLSAVRRGEWAHAANLLAGAAQLRCVPTIRTYAEVIAANSLNGTWEDAVRVVDLLQSSPLSSRALLCTAADALLMKPSVCATEKLFSIILAARRRRVQMEVRHQVQCSRLLVEAGDWQRALTLGAYGRPVRQIPALASPMMLAAATGRRWMEGSRIMADLLISGTVPGADVAKNYIRCFTPTGPWWRALAVVSVLVCSSDAGVTAAARGLLREVRSGVGEAELAAKKARYQTVLRLVERRGPLNDVSVEEASYVLNALGEERWEEALGIIRAFPSLLSFTPRPRAVLLPTAVHKTQAGCYKHWEFVWKVLSSGFSSNSAEHVFGAATCFASYVSSACRAGEEQSECMREVELMGNSMSSSIVDYRALGGGLPEYDVLNSFVRASCACGWWKDALLLSERRAVVLRELLEVGPWQAALAVYEGMPPSARERMGPKLEYLFISRGLWVPALQYAQQRLPRDTLPLRNLSIPLCAALGQWGRTLHLLDRYVSLPTDTEKILRKKCITKDAEDSVRAACEAGDWVRALRAWSRVYSVPRRQRQPVLDESRRRFEMVPEVVKQLAKLLLAAKRYDECCGVVSSHTPTPSDPVVLRCLQLFNGVRSSPLTYGRLLQEYREAHKHHRVLVECYAVLALCVSGNFCGAFSVVQQLTAQNFGRLEKDVTVFSVLEEVPHLKAYLPLILCAVATPARAVELEAVMVSLTWCIKLPNDTDLFNRPLSALWGSGADEPRACAFRVAVFVLQHSLDHDLPSSWVVMDVVARSLEDSSRRSVIHMLCESAVRRLAFDAEQNGTESGQHGVRQGKGQEEVNVVFRSCATAFARKGLWEHALASIQHCETVDAGTLLSIIVFTKELRERRLATAQRIVLELETRRRSDGDEPEYPPGTSVSKGRVESALVALTELRAWRAALVLFNSEEAQLCLLSSGVRKTSSTVVGLLVSCVAVSGPWELSLRLLEAVHCNILPSCPLVEKGLTDVLGAVDSGSGAAMCSQVLLFMVERMGVVPTSGQYGLLLRSCLEVRLTVAERELCARTLKRLSRCLNERQVVDLVGAISTSRLPSNPWNEEGHPGTLYSFPTGSLSKKRVQQLAPALGWMREDRPFLNDGELNQLCEIAPLVTILNAQDMERLSQQFLGGRFASFELMLVLQHYRQELMEMFEQNGDDSVNVSLLEHCRGSRLLHIMLVPYEQLSHNMICNGNESSAMSFLQEVRWGVFRGFASVRTVAAVWEACRSLVSDLAAGRWTRLCECELLTEVRRRRGRPPVSLITRPGATRSEIAKYWATYGRIVWPELYFSGPELCQLAVYVPLLEPLLRRDQELRELVFGIHASHFAFHSIPSGELLFRRPRSPEAIRAVIHLVFGKLKRLHSELDADKRGARRYYRHTPDMVLWQRTERAIQKRQESADQSAMGGTVEEQTPRWSLALRILYHYRRSTKVTLKVTALAALFSACAADVEGGNVQISCQSRKQGKRLGEISWWMLSIYCARFVEPNLTLTMWRDAMKLAVLPSVSNPPKTLLTSTYGLEDINDISLRATMQVLMCQVNDASGNGRVPFSTSLLLVDQLKESLSAPHHFPSYCVSLDVYRCYRPLECASKGESDALTVWSLLQTHRCLEKMEPLHANLVRRMLLGGKGFGETGTCSRCRKGI
Protein: histidine kinase (EC 2.7.13.3) (B9UP04)
Organism: Aliivibrio fischeri (Vibrio fischeri)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}.
Interaction partners:
Sequence:
MKNQLLRYSLITIITCTLVIISLIITRNHLVEQYQRAYLTLSHNIIQSRENIYHFNHQDNKTYDEYASLLVDSELQASFLYNRLKDSRTSSWLEFFLISDNQAILVSQNTYSNIVAIVTDLESLLRLKVSKEYTTHTIFLLEKQLINNVQNVEDKYLISQLTLHGTLPKEKTLSDTTLNDSDFTSLSNYIKLRERIDSEQKEKEQSIFNNTVKQTLTKQNAYWITQSEAIKTQLFITTLFLLCCIALYFYIRLRDKFIQTLTIKRELIRSEKEKTKLALVAEHAHNAIFILDKQSKLTWINQSYSVLSGNTLEDIKGKDLPSVLQLDKIQHANIFTLLQSLKAGTSVSFELTNNHKDGTLYWIDVSVTPIFKPNGNIMHYVVVERDITKKKELEDKLIKAADKADVSNKAKSTFLATMSHELRTPLNGILGMAQIIESNIKDEEQHKQIKVLLESGDHLLSLLNDILDFSKIEQNKLELNHASFYFNDVIDPIANTYQSICEDKGLQFIIDNNINEKTIFIGDKPRIRQIIFNLISNAVKFTHKGSITLNFSHTLTAKGEQAVQIKVQDTGIGIRKKRLKHIFEPFIQAETSTTRQYGGTGLGLAIVKQLTDTMKGYISVNSSEGKGTCFTLVLPLEITKSKQLIDSDALPSDKNKPTEPTSITNLSILIAEDNKINALVAQMFCQRLGHKAIIAENGKVAIEKLKETHFDLIIMDNHMPVMDGILATKAIREELKLSTVIFACTADVFQEAHDNFLKAGANYVLTKPLQENGFIDAIKQHQDAIIQQKRTSCPTQEKNSNIIELKRPSKYQLSDDALTEAEIKLTSIQDICGTDSEVICVFLQSFIDTSEENITEIITAFERKDIKSIRFNAHSIKGMASNFNAPRLIKIATSIELHAKEQTMPMLEDVQQLINLLEVNIQQASRLLEKYETQQISSQKGNP
Protein: Protein RIC-3 (Resistant to inhibitor of cholinesterase 3) (Q8BPM6)
Organism: Mus musculus (Mouse)
Function: Molecular chaperone which promotes the proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) nicotinic acetylcholine receptor. Promotes the proper subunit assembly and cell surface expression of alpha-8 (CHRNA8) nicotinic acetylcholine receptor (By similarity). May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4 (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19812337}; Single-pass membrane protein {ECO:0000269|PubMed:19812337}.
Interaction partners:
- Protein unc-50 homolog
- 5-hydroxytryptamine receptor 3A
- Novel acetylcholine receptor chaperone
- Neuronal acetylcholine receptor subunit alpha-7
Sequence:
MAYSTVQRVALASGLVLAVSLLLPKAFLSRGKRPEPPPGPEGKLDRFPPMMHHHSAPSDGQTPGARFQRSHLAEAFAKAKGAGGGAGGGGSGRGLMGQIIPIYGFGIFLYILYILFKLSKGKTAEDRNCSTAPPGNAHRKITNFELVQLQEKLKETEEAMEKLINRVGPNGESRAQAVTSDQEKRLLHQLREITRVMKEGKFIDTSPEKEAEEAPYMEDWEGYPEETYPIYDLSDGIKRRQETILVDYPDLKEPSAEEIAEQMGEIEEEGSERLSWDHLPTDPGAQKDNSVAPCDPKPESCSCCVHEEEDPAVLAENAGFSADGYSEQEEATKENLPQDFTNEGLGVSTDNAHVGGMLRKRNPQGFE