wanglab/gogpt-training-data huggingface dataset:
Protein: Protein SGT1 (Suppressor of G2 allele of SKP1) (Q08446)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Required for both entry into S phase and kinetochore function. Also involved in cyclic AMP (cAMP) pathway, possibly by participating in the assembly or the conformational activation of specific multiprotein complexes.
Interaction partners:
- ATP-dependent molecular chaperone HSC82
- ATP-dependent molecular chaperone HSP82
- Suppressor of kinetochore protein 1
- Adenylate cyclase
- Centromere DNA-binding protein complex CBF3 subunit C
- Hsp90 co-chaperone Cdc37
- Hsp90 co-chaperone AHA1
- Heat shock protein STI1
- Centromere DNA-binding protein complex CBF3 subunit B
- Mevalonate kinase
Sequence:
MPVEKDLKTAYKALYDEKEPLKALHLYDEILKGSPTNLTALIFKAACLEKLYFGFSDWHSDATMENAKELLDKALMTAEGRGDRSKIGLVNFRYFVHFFNIKDYELAQSYFKKAKNLGYVDDTLPLWEDRLETKLNKKNKKQKDSTNKHTIKPVESIENRGDNNSSHSPISPLKIETAPQESPKFKIDWYQSSTSVTISLFTVNLPESKEQVNIYISPNDRRTLSISYQVPKSGSEFQYNAKLSHEVDPKAVSLKIFPKKLEITLSKIDSTQWKKLEEDILTESSRLSDEGKNSDSATRLLSAETASKERLSYPSSSKKKIDWSKLDIDEEADEEAGSADSFFQKLYAGADPDTKRAMMKSFIESNGTALSTDWEDVSKGTVKTSPPEGMEPKHW
Protein: General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon) (Q8R2T8)
Organism: Mus musculus (Mouse)
Function: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- General transcription factor IIIC, polypeptide 3
- General transcription factor 3C polypeptide 4
- General transcription factor 3C polypeptide 2
- General transcription factor 3C polypeptide 1
- Transcription factor IIIB 50 kDa subunit
- DNA-directed RNA polymerase subunit
- General transcription factor 3C polypeptide 6
- Transcription factor TFIIIB component B'' homolog
- DNA-directed RNA polymerase III subunit RPC7
- Transcription factor IIIA
Sequence:
MAAAEPDADPKAAIPVDLRRERRLVCVEYPGVVRNEAKMLQTLGGEESVSRIYTDPTKRLELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRRRGVLGDEAHPQVTFNLEIIGIISTIYKFQGMSDFQYLAVHTEAGGKHVSMYDRVLMRKPEKEEFFHQELPLYIPPPIFSRLDTPVDYFYRPETQHREGYHNPTISGENLIGLSRARRPHNAIFVNFEDTEVPEQPLEAAVQTWKKACTNPIDQKVEEELRKLFDIRPVWSRNAVKSNVSVHPDKLKILLPYMAYYMITGPWRSLWIRFGYDPRKHPDAKIYQVLDFRIRCGMKYGYGSRDMPVKAKRSTYNYSLPITVKKTSNQPGTMHDLKQGLGPSGTDGPRKLTYNKYKLKDSVYIFREGALPPYRQMFYQLCDLNVEELQKIVHRNDGTETVCTERDGWCLPKTTDHLRDTMSLMILQTIRSERPALFSNTGKADRGKEQLMFESGEEEEEEEEEEEEEEEDFKPSDGSENEMETEILDYV
Protein: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (O44501)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein farnesyltransferase subunit beta
- Geranylgeranyl transferase type I subunit beta
- Farnesyl pyrophosphate synthase
- CAAX prenyl protease 2
- CAAX prenyl protease 1 homolog
- Alkyl transferase
- All trans-polyprenyl-diphosphate synthase PDSS1
- Ras protein let-60
- Protein SEC13 homolog
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MSDSDIPSSTLYKDNVDWKDITPIYPSKEEEVAVKIAVTEDFTDAFAYFRAILIKNEKSDRVMALLEDCIRLNPANYTVWQYRRVCLTELGWDLKKEMRYLSDIIQESPKNYQVWHHRRFIVETIGESAVNDELHFCSEVIRDENKNYHAWQHRQWVVRTFKVPLEKELTFALHMLLLDNRNNSAYNYRYFLMTLYDKTEDASQLDIEINLAKKFIENIPNNESAWNYLAGLLITNGVTSNSDVVSFVEDLYETTPEEKRSPFLLAFIADMMLENIENQKSAEESAGRAKKLYKDLQSIDPVRVNYYRHQSLLAQTMLIKAQTKVTAK
Protein: Forkhead transcription factor fkh-9 (Q21187)
Organism: Caenorhabditis elegans
Function: Transcription factor. Binds to the regulatory elements of genes that contain the sequence motif 5'-TTGTTTCT-3'. Involved in regulating intestinal transcription of vitellogenin vit-2, acting in concert with transcription factors elt-2, mab-3 and daf-16, and also the TGF-beta/Sma/Mab pathway. Functions downstream of the insulin/IGF-1-like signaling (IIS) mediated pathway, in regeneration of axons after injury and in short-term memory, perhaps acting in neurons, and in modulation of longevity, perhaps acting non-neuronally. Plays a role in the modulation of endoplasmic reticulum (ER) homeostasis during chemical and pathogen stress, including exposure to the Gram-negative bacterium P.aeruginosa.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:26675724, ECO:0000269|PubMed:30287474}.
Interaction partners:
- Forkhead box protein fkh-3
Sequence:
MCSTMTATMNQTICEKQNITMDLLRSPIQIPSASDTIKIETPSTISSQPSPIQTPLAAASSDNFERPSLSYKDLIIEAIDRSPEKRLKLNEIYQVIRLLHPYYRHRPDQWGWQNSIRHNLSLHDCFVKLPLKQTSASGVVGHFWTVVPELSDKQTLRRRNRQQPRALAKKSDAGRTLSRDDRGSSGSGETSPSPSQPSISPPNENPMPSVQALNVLELLSGMNDYKGTLFQNNYRTNLIQDNSAVNGLQNLLTTTLMQINPQLGALLSLANLNNLTTNQLQIASPSLSPIKAESQSFLLQ
Protein: Trafficking protein particle complex II-specific subunit 130 (TRAPP II-specific subunit 130) (Transport protein particle 130 kDa subunit) (Q03660)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchange factor (GEF) for the Golgi YPT1 GTPase. TRS130 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS120. Required for both the cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy through its role in ATG8 and ATG9 trafficking.
Subcellular location: Golgi apparatus {ECO:0000305|PubMed:11239471}.
Interaction partners:
- Trafficking protein particle complex subunit BET3
- Trafficking protein particle complex subunit 31
- Trafficking protein particle complex subunit 20
- Trafficking protein particle complex II-specific subunit 65
- Trafficking protein particle complex subunit 33
- TRAPP-associated protein TCA17
- Trafficking protein particle complex subunit 23
- Trafficking protein particle complex subunit BET5
- Trafficking protein particle complex II-specific subunit 120
- Trafficking protein particle complex III-specific subunit 85
Sequence:
MDKEIYCGSVPVSYFDPFDLFESLRPEFQQILPLDNIHWKAFDGTVRTVNRLPIELIPEGRGEADKSNDEQPFIRFLIVNCISIDQYRAKVRPLVRQWLPNLESVSSSTGEKMIYKPIILLYANSEVVDSNLFKSVSLMEKFGKDFPHVQTLEVRSVYRSPKERQEFWNQFSQKIKASVLSIFQKRLTHLQHSLANLQKGNNFEEQLLTREKLYELYVVFNILEDASLELQKIKKEILRRNMNMPDGKLQVPFESSSKSDESLGSIIIEGTLDKFQLHKYFFIRRLRLLKLEDQTLTAFVGAFQLIKNFIESISIEYRKSVRLLEFKHYFITSMLSYFEFENVSNPLLCEIKAELLMLKRDNWVQGVMATSGYRLMDKNYPNSDVKYKFDLLKETFVDETVFQENFLTLTKEILSLFNKCEGKRQRIVDILSIEIGLLYYQGKKYEEAVSLFLSCYEYYTQTNWNSIGLKILQVFIDSLSHCPKLDVLQIDGESVSASAVLTNAFLNILKLCKDNDSKEIWWKKFMDLQMKNNIHLMYPLDGLFEVTLNSKVHLARANVSAIEVNLKSYGFPEDISTKTMRLSLKNMGGDVIVFGASDFLLKKGENKLILECRDIMYGEFSLLSFEIIVEGITFVKEFPENQDEFIVVPEIYCKESTKVLVKQAHNLNLGEYALELKSVQSDALESLQVEVEVQKNIGNMKNLPVSFSMDEIQARKRYNTPFENVRLEYYLLDQITAFDLIIKTSFTKKNDQGTFGETKKVRIQCYLQLSVSVEDIFKKDIFFFKFLLNSSVREEPVILYSSELSAPDTRNDYNIRGDYIATTPALITFDGNESFINCYEITANNNFDSKDIFNLKVRYNTLKEQLDCFITDAVLIEGDVEWFILFEKWKTFWELEILKKLKYDYDAFKENRIIRLLKTSIDLNKTKSKIRNLCIEKAVLDKILICLNKVSRGIAVCNTDMDEYVRNLVPKQLTVPVQLPGFEQFFHVQFEQMETSHDALHDTIATIGNSLSYTVIVENLSGQWGQDVIDDGGYIFEILSSNEWLIHGQKRCAIKEKRKEFEVHLIPLKKGYLNFPRVEITNINGKSCRVDHSNAFESILIF
Protein: PsbP domain-containing protein 5, chloroplastic (OEC23-like protein 6) (PsbP-related thylakoid lumenal protein 4) (Thylakoid lumenal 35.8 kDa protein) (P82715)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in strigolactone biosynthesis.
Subcellular location: Plastid, chloroplast thylakoid lumen {ECO:0000269|PubMed:11719511, ECO:0000269|PubMed:18431481}.
Interaction partners:
- PsbP domain-containing protein 6, chloroplastic
- PsbP-like protein 1, chloroplastic
- Photosynthetic NDH subunit of lumenal location 1, chloroplastic
- PsbP domain-containing protein 3, chloroplastic
- Oxygen-evolving enhancer protein 2-1, chloroplastic
- PsbP domain-containing protein 4, chloroplastic
- Thylakoid lumenal 17.4 kDa protein, chloroplastic
- Tagatose-6-phosphate ketose/aldose isomerase, putative
- Uncharacterized protein At5g19190
- Peptide transporter family protein
Sequence:
MALLCPSLPSPNSRLFRCRSSNISSKYHGASKELMIARSGVSTRSISSEKGLSRRDLVLIGLSSPLSMFLPLSSPVTHAEEDVKMSGEELKMGTMVDDINAYSYAYPLDYPSEKLVFKWVESRKPERYSSAAPLSPDARLRIVSERVDLTDNLVISISIGPPNSRLTSKEKKTWSAKEVADSVLSDKSALRVTSSQRLEESSVLDAHASDIDGEPYWYYEYLVRKSPTKIAEASKLYRHYISSTAERDGYLYTINASTLGKQWDKMGPVLERAVGSFRLLPPTDSYVPPYKDPWRFW
Protein: IP12536p (LD13269p) (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform D) (Uncharacterized protein, isoform E) (Uncharacterized protein, isoform F) (Uncharacterized protein, isoform G) (Uncharacterized protein, isoform H) (Q95RS6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNGYTNNCISICAILLIGVSSPAPQQNINAQKNIEEIFNTNSNLSAQKESGIGLVITPDPMETISQQSNFTSTSGKTATCNCVPYYKCDPSTKSFTEDGSFDGFGVIDIRFNDDDPICPASVDVCCDANRTLNKTLNPTPLDQRPNQPRGCGVRNTGGLDFTLSGVSQNEAGFGEFPWTVALLHSGNLSYFCAGSLIHKQVVLTAAHCVESLRTGSFTVRAGEWDTQTMKERLPYQERSVQTVILHPDYNRRSIAYDFALVILSQPVTLDDHINVICLPQQDDIPQPGNTCFSTGWGKDAFGSLGKYSSLMKRVPLPIVEFNSCQTRLRGTRLGPKFALDRSFICAGGQRGIDTCQGDGGAPLACPRGSTRESRYQQTGIVAWGIGCNDEVPAAYANVALVRGWIDQQMLTNGFGTAVYTA
Protein: o-succinylbenzoate synthase (OSB synthase) (OSBS) (EC 4.2.1.113) (4-(2'-carboxyphenyl)-4-oxybutyric acid synthase) (o-succinylbenzoic acid synthase) (P29208)
Organism: Escherichia coli (strain K12)
Function: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). Does not show detectable N-acylamino acid racemase (NAAAR) activity with N-acetyl-S-methionine as substrate.
Interaction partners:
- 1,4-dihydroxy-2-naphthoyl-CoA synthase
- 2-succinylbenzoate--CoA ligase
- 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
- 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
- Isochorismate synthase MenF
- L-Ala-D/L-Glu epimerase
- 1,4-dihydroxy-2-naphthoate octaprenyltransferase
- Protein ElaA
- Protein ElaB
- Fumarate reductase subunit C
Sequence:
MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLREGEREGWGEISPLPGFSQETWEEAQSVLLAWVNNWLAGDCELPQMPSVAFGVSCALAELTDTLPQAANYRAAPLCNGDPDDLILKLADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNPDYRDRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEEGVRAVVIKPTLTGSLEKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQVRRWPGSTLPVVEVDALERLL
Protein: Probable proteasome subunit alpha type-5 (Q9UT97)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable proteasome subunit alpha type-1
- Probable proteasome subunit alpha type-6
- 26S proteasome regulatory subunit rpn11
- Probable proteasome subunit alpha type-7
- Probable proteasome subunit alpha type-4
- Probable proteasome subunit beta type-5
- Probable proteasome subunit beta type-6
- Probable proteasome subunit alpha type-2
- 26S proteasome regulatory subunit 7 homolog
- Probable proteasome subunit beta type-3
Sequence:
MFMTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGVKTKDAVVLGVEKRLTSPLMESHSVEKLFEIDSHIGCAISGLTADARTIIEHARVQTQNHRFTYDEPQGIESTTQSICDLALRFGEGEDGEERIMSRPFGVALLIAGIDEHGPQLYHSEPSGTYFRYEAKAIGSGSEPAKSELVKEFHKDMTLEEAEVLILKVLRQVMEEKLDSKNVQLAKVTAEGGFHIYNDEEMADAVAREQQRMD
Protein: small monomeric GTPase (EC 3.6.5.2) (F1NSA8)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEEERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL
Protein: N-acetylglucosaminylphosphatidylinositol deacetylase (EC 3.5.1.89) (Q5AS22)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Uncharacterized protein
Sequence:
MKFPLPLPTLLGALTLLTPAFSANTLNIVAHPDDDLLFLNPDIQNDISSGFNVRTVYLTSGDAGQPYEYWTLRQAGLLTAYAQMAGVESIWDESDAGVAGKDIPVYTLRPKPEVSLAFMHIPDGSMDGNGFPATGQESLEKLWKGAIARIRTVDASGTTYSRGELVETLRQIIDSFVPDSLNSLDYVHPYGSGDHSDHTSAGLFTNTAAITSSFPGSVIAYRGYPIKSEPANVGGEDLVRKKEVFYTYAAFDEDVCGSDQACAGKEYELWLPKQYTAN
Protein: Uncharacterized protein (Q57XE3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- ATP-dependent RNA helicase
- Uncharacterized protein
Sequence:
MKKRVAVSCCVAGVLLFAAAVAIHRTAPTTIEQKKLAAWVYTGFRSATERTKATVTALVPEPMKPHIKQLLAGATSVTLVGQGFRRIPGIATAISASAQTTKQQNVVEIIMAKPVDKLLYAVGAIFAQAFLLRLLVKPPGYWGPVKDQKVWRNFFTTQAGWFLLVVCVALPNCVVDAGFIITLLGRLPSETYLPALVVGKLLQPYVATALFCSPTFVRWLPQVWKVMDAKGSEDDQSGAKVVFWALLTTAVLLAGTNGVTMLWRRDGSNDEEEELVLEDAEAEN
Protein: Beta-galactosidase 12 (Lactase 12) (EC 3.2.1.23) (Q9SCV0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Protein ALP1-like
- non-specific serine/threonine protein kinase
- Protein DETOXIFICATION 29
- Xyloglucan endotransglucosylase/hydrolase protein 2
Sequence:
MGLNFREKAWILLGILCCSSLICSVKAIVTYDRKAVIINGQRRILLSGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGQYYFEDRYDLVKFIKVVQQAGLYVHLRIGPYVCAEWNFGGFPVWLKYVPGMVFRTDNEPFKAAMQKFTEKIVRMMKEEKLFETQGGPIILSQIENEYGPIEWEIGAPGKAYTKWVAEMAQGLSTGVPWIMCKQDDAPNSIINTCNGFYCENFKPNSDNKPKMWTENWTGWFTEFGGAVPYRPAEDIALSVARFIQNGGSFINYYMYHGGTNFDRTAGEFIATSYDYDAPLDEYGLPREPKYSHLKRLHKVIKLCEPALVSADPTVTSLGDKQEAHVFKSKSSCAAFLSNYNTSSAARVLFGGSTYDLPPWSVSILPDCKTEYYNTAKVQVRTSSIHMKMVPTNTPFSWGSYNEEIPSANDNGTFSQDGLVEQISITRDKTDYFWYLTDITISPDEKFLTGEDPLLTIGSAGHALHVFVNGQLAGTAYGSLEKPKLTFSQKIKLHAGVNKLALLSTAAGLPNVGVHYETWNTGVLGPVTLNGVNSGTWDMTKWKWSYKIGTKGEALSVHTLAGSSTVEWKEGSLVAKKQPLTWYKSTFDSPTGNEPLALDMNTMGKGQMWINGQNIGRHWPAYTARGKCERCSYAGTFTEKKCLSNCGEASQRWYHVPRSWLKPTNNLVIVLEEWGGEPNGISLVKRTAK
Protein: MCE family protein 4D (Virulence factor Mce family protein) (O53541)
Organism: Mycobacterium tuberculosis
Interaction partners:
Sequence:
MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNKRTIVGYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVDVQAVIMSPNLVAARFIQLTPVYTGGAVLPDNGRIDLDRTAVPVEWDEVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLSDQSENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKGQIIYDTPATEAKSETPVPELTWVPAGGGAPVGNPADLQSLLVPPAPGPAPAPPAPGAGPGEHGGGG
Protein: Large ribosomal subunit protein uL1A (60S ribosomal protein L1-A) (L10a) (P0CX43)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL1 forms part of the L1 stalk, a mobile element that plays a role in evacuating the exit-site tRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:22096102}.
Interaction partners:
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL5B
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein uL4A
- Small ribosomal subunit protein uS10
Sequence:
MSKITSSQVREHVKELLKYSNETKKRNFLETVELQVGLKNYDPQRDKRFSGSLKLPNCPRPNMSICIFGDAFDVDRAKSCGVDAMSVDDLKKLNKNKKLIKKLSKKYNAFIASEVLIKQVPRLLGPQLSKAGKFPTPVSHNDDLYGKVTDVRSTIKFQLKKVLCLAVAVGNVEMEEDVLVNQILMSVNFFVSLLKKNWQNVGSLVVKSSMGPAFRLY
Protein: Double-strand break repair protein rad32 (EC 3.1.-.-) (Q09683)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51.
Subcellular location: Nucleus {ECO:0000269|PubMed:12944482}. Chromosome, telomere {ECO:0000250|UniProtKB:P49959}. Chromosome {ECO:0000269|PubMed:23080121}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000269|PubMed:23080121}.
Interaction partners:
- DNA repair protein rad50
- DNA repair and telomere maintenance protein nbs1
- Exodeoxyribonuclease 1
- ATP-dependent DNA helicase II subunit 1
- ATP-dependent DNA helicase II subunit 2
- Serine/threonine-protein kinase tel1
- Flap endonuclease 1
- Protein kinase rad3
- DNA endonuclease ctp1
- DNA repair protein rhp51
Sequence:
MPNDPSDMNNELHNENTIRILISSDPHVGYGEKDPVRGNDSFVSFNEILEIARERDVDMILLGGDIFHDNKPSRKALYQALRSLRLNCLGDKPCELELLSDTSLTTGDTAVCNINYLDPNINVAIPVFSIHGNHDDPSGDGRYSALDILQVTGLVNYFGRVPENDNIVVSPILLQKGFTKLALYGISNVRDERLYHSFRENKVKFLRPDLYRDEWFNLLTVHQNHSAHTPTSYLPESFIQDFYDFVLWGHEHECLIDGSYNPTQKFTVVQPGSTIATSLSPGETAPKHCGILNITGKDFHLEKIRLRTVRPFIMKDIILSEVSSIPPMVENKKEVLTYLISKVEEAITEANAQWYEAQGTVPVVENEKPPLPLIRLRVDYTGGYQTENPQRFSNRFVGRVANATDVVQFYLKKKYTRSKRNDGLYTSAVEDIKINSLRVESLVNEYLKTNRLECLPEDSLGEAVVNFVEKDDRDAIKECVETQLNKQINLLVKKRVTEENLEQEISSIINDLPKISTTKRKDYEELPEEVSETSINIAEHTPVLKHTSSLLDHHSPLATSSSEHEMEATPSPALLKKTNKRRELPSSLTKKNTRTPQRSKEVKKVPARKLSQSTKKSDKNTQSTLLFYDPSSTTEAQYLDNEDDEILDD
Protein: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Phosphatase and tensin homolog) (Q7ZZ56)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. Cytoplasm {ECO:0000256|PIRNR:PIRNR038025}. Nucleus {ECO:0000256|PIRNR:PIRNR038025}. Nucleus, PML body {ECO:0000256|PIRNR:PIRNR038025}. Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}.
Interaction partners:
Sequence:
MAAIIKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKDHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDKWLSENDNHVAAIHCKAGKGRTGVMICAYLLHRGKFKKAQEALDFYDEVRTRDKKGVTIPSQRRYVYYYSYLLRNKLEYKPVALLFHKMVFETVPMFSGGTCNPQFVVYQLKVKIHTSNPAHTRREEKYMFFEFPQPLPVCGDIKVEFFHKQNKMMKKEKMFHFWVNTFFIPGSEESTEKVENGGLVKDLDGIQTAERGENDKDYLILTLSKTDLDKANKDKANRYFSPNFKVKMFFTKTVEEPSNSEASTSTSVTPDVSDNEPDHYRYSDTTDSDPENEQYDEEQITKV
Protein: Autophagy-related protein 18f (AtATG18f) (Q9FH32)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy (By similarity).
Subcellular location: Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Peripheral membrane protein of pre-autophagosomal structure (PAS) and vacuole. {ECO:0000250}.
Interaction partners:
- Ubiquitin-like-conjugating enzyme ATG10
- Autophagy-related protein 18a
- Autophagy-related protein 18e
- Heat stress transcription factor A-1a
- Ubiquitin-like modifier-activating enzyme atg7
- Autophagy-related protein 18c
- Serine/threonine-protein kinase ATG1c
- Autophagy-related protein 18d
- Autophagy-related protein 8d
- Autophagy-related protein 9
Sequence:
MKKNGDGSSPKSPDGVVSRSARSSFRALSNCLKVISSGASTVARSAVSAASSAVESHHDQVLWAGFDNLQKEDGDTRRVLLLAFKSGFQVWDVEDTENVHVIVSAHDGQAFFMQMLLNPINSGVLDDRFYKSRPLLAVCGDYSSKKISSDNPGSETVATPTNVYVYSLKSQSYVHTLKFRATIYSVRCCSRIVAVLQAAQIDCFDAATLEMDYRIVTNSIVCGSLGVGYGPLAVGPRWIAYSGSRIATSSSAIFTSEIVSLSTSSPSVAQFARDSSKQLASGIANLGDKGYRSLTKYCSEVLPNPYIPGLKGIGVGNEKVADAESIGMVIVKDITNKSVITQFKAHKSPISALCFDQSGLLLVTASIQGHNINVFRIMPTISTSRAVKTTTFAHLFRLQRGFTNAVIQDICFSKDSNLIVVGSSRGTSHLFEINPEKEGDAPVPMSAISRIRSGNSSGWIGTVSGAASAAAGMVAGSVPGTVTSTFCYCDEKSNNNYYGSVADMCSKTNLLVFAPSGCMTQYALREHQVGVGHETAAMTGFDSESGLETEGKLAVDPIRRWSMIQNQSRRETHDPHSDIYGGGTSVDSKSKVFPEVVRKQSVEEAWKVSKKGTTRVVDKRHLYIYEAEQQQTHLPTQLPLWARRKFRFQELVLNRGEEISGGGGREMEIEGIQTRTIEARTRDLVPVWGYLQSPRSQQVINESIQSPSTTTQDDKVATLEGHGTETDLGAVHSEEQTQSEPVDKEGIAEEKNHSEDEDEEQVD
Protein: p-GlycoProtein related (Q19733)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- MFS domain-containing protein
Sequence:
MKWRKNGDAIEPIDGIPMENGKKKDTTVNVSTEDVGSIDSDEEPKIVYEPSKMEKLINYMLCRGDLASRELSVKPVTLLGLFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLLIHNATSDDFYDSAMTNVWLFGGIGIIVLIVNFVQYMCFQYCCIRITSKMKQHYIQSILRQNAGWFDKNHSGTLTTKLHDNMERINEGIGDKLGVLIRGMVMFVAGIVISFFYEWRLALMMMGIGPLCCVCMSLMSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQAFNGQEEMVEKYTVELGKGKSFAIQKGLWGGVFGGIFLLFLFSYFGGGIYYGGQLLRWKIIETPGDVFIVVISMLIGAYFLGLISPHLMVLLNARVAAATIYEIIDRTPDIDVYSTEGQKMTNVVGKVVFEEVHFRYPTRKKVKVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRSLNIDWLRKTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGYETMIGDGSVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRTTIMIAHRLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQKFKESDDIEDNGDEHEEETSTVGRHDRLSSRQVSFHKSCESLASADLEIGYASTFNTFTLKTAQEEIENEDFAEEVQRVMEEDGVINSGYLDIFKNAQGNYLYLSVGTFFAILRGSELALLANMFGFVFAAFKEPEDEMVKALGLIFILYVALGLFVFITQVISGTLFTIVAENLGLKFRVQSFKNLLYQDASFFDNPAHAPGKLITRLASDAPNVKAVVDTRMLQVIYSITSITINLITGYIFCWRIAIAGTIMIVLFATMMISMAYKIARENLKQIRKDEAGKIAIEIIESVKTIQLLTSTQRFLTHYKDAQLVQHKSEMRKSYIQSVNNAISQTFMYFAMFVCYGVGTPLMYHGIVEAEPTFRAINCMMMGSVAVMHSSHNFPEFVKAKTAAGMLFKLIYRKSKTGDVMEGNNTEIRGNVLFESVKFSYPQRPMQPVMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQNIKSLSLHHLRTQMALVGQEPRLFAGTIKENVCFGLKDVSVEKVHQALELANASRFLANLPAGIDTEVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDHGMVQEAGNHAHLMSLRGKYYNLIKKQDLTT
Protein: SPRY domain-containing protein 7 (Chronic lymphocytic leukemia deletion region gene 6 protein) (CLL deletion region gene 6 protein) (Q5W111)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATSVLCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDMHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF
Protein: E3 ubiquitin-protein ligase RNF144B (EC 2.3.2.31) (IBR domain-containing protein 2) (RING finger protein 144B) (p53-inducible RING finger protein) (Q7Z419)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:20300062}; Single-pass membrane protein {ECO:0000269|PubMed:20300062}. Cytoplasm {ECO:0000269|PubMed:20300062, ECO:0000269|PubMed:39285245}. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Interaction partners:
- RNA/RNP complex-1-interacting phosphatase
Sequence:
MGSAGRLHYLAMTAENPTPGDLAPAPLITCKLCLCEQSLDKMTTLQECQCIFCTACLKQYMQLAIREGCGSPITCPDMVCLNHGTLQEAEIACLVPVDQFQLYQRLKFEREVHLDPYRTWCPVADCQTVCPVASSDPGQPVLVECPSCHLKFCSCCKDAWHAEVSCRDSQPIVLPTEHRALFGTDAEAPIKQCPVCRVYIERNEGCAQMMCKNCKHTFCWYCLQNLDNDIFLRHYDKGPCRNKLGHSRASVMWNRTQVVGILVGLGIIALVTSPLLLLASPCIICCVCKSCRGKKKKHDPSTT