wanglab/gogpt-training-data huggingface dataset:
Protein: Lipoxygenase (Q9AXG8)
Organism: Zea mays (Maize)
Interaction partners:
Sequence:
MLSGIIDGLTGANKHARLKGTVVLMRKNVLDLNDFGATVVDSISEFLGKGVTCQLISSTLVDANNGNRGRVGAEANLEQWLTSLPSLTTGESKFGVTFDWEVEKLGVPGAVVVKNNHAAEFFLKTITLDDVPGRGAVTFVANSWVYPAGKYRYNRVFFSNDTYLPSQMPAALKPYRDDELRNLRGDDQQGPYQEHDRVYRYDVYNDLGEPDGGNPRPILGGSADHPYPRRCRTGRKPTKTDPNSDSRLSLVEQIYVPRDERFGHLKMSDFLGYSIKAITQGIIPAVRTYVDTTPGEFDSFQDIINLYEGGIKLPKIQALEDMRKLFPLQLVKDLLPAGGDYLLKLPIPQIIQEDKNAWRTDEEFAREVLAGVNPMVITRLTEFPPKSTLDPSKYGDHTSTITAEHIEKNLEGLTVQQALDGNRLYILDHHDRFMPFLIDVNNLEGNFIYATRTLFFLRGDGRLAPLAIELSEPYIDGDLTVAKSKVYTPASSGVEAWVWQLAKAYVAVNDSGWHQLVSHWLNTHAVMEPFVIATNRQLSVTHPVHKLLSSHFRDTMTINALARQTLINGGGIFEMTVFPGKYALGMSSVVYKSWNFTEQGLPADLVKRGVAVADPSSPYKVRLLIEDYPYASDGLAIWHAIEQWVGEYLAIYYPDDGALRGDEELQAWWKEVREVGHGDHKDAPWWPKMQAVSELASACTTIIWIASALHAAVNFGQYPYAGYLPNRPTVSRRRMPEPGSKEYEELERDPERGFIHTITSQIQTIIGISLIEILSKHSSDEVYLGQRDTPEWTSDARALAAFKRFSDALVKIEGKVVGENRDPQLRNRNGPAEFPYMLLYPNTSDHSGAAAGLTAKGIPNSISI
Protein: Jabba, isoform D (B7YZK6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAQETKTVATAKDQNQRDHIDEEEVIELHESRSFYDRVREQAERFASTRVGQFVIERADKALAMIEDTAKWSLPQDKSSAPLERPLPWAPFLMLIVLLRLTRIWLSVGALMIGNGPISPTDMVYFIQTRRRKLRAIRVHGLKVMRRRQQEVSYGSGKGMTQKLNQWFSRAMCRPGVQQDSSSRRVFVRHSEQGLSNFVVKRPREEDCNADADLTIDQMLAKYANENSEDDSDFVPNEEEEEEESSSSSGESESESGSSEGISSGEVDEVVSQPKQKSAGAVVENGVHKAEEKENDKGKLNITTTSNGNNDKEQADVAAAQPDEEWKSSPGHMSAAVMNTRLYNNTAAAVFCLCFCYSVHVFKHNSHH
Protein: Leucine-rich repeat protein kinase family protein (F4I9D5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MMGICEMKSCCSWLLLISLLCSLSNESQAISPDGEALLSFRNAVTRSDSFIHQWRPEDPDPCNWNGVTCDAKTKRVITLNLTYHKIMGPLPPDIGKLDHLRLLMLHNNALYGAIPTALGNCTALEEIHLQSNYFTGPIPAEMGDLPGLQKLDMSSNTLSGPIPASLGQLKKLSNFNVSNNFLVGQIPSDGVLSGFSKNSFIGNLNLCGKHVDVVCQDDSGNPSSHSQSGQNQKKNSGKLLISASATVGALLLVALMCFWGCFLYKKLGKVEIKSLAKDVGGGASIVMFHGDLPYSSKDIIKKLEMLNEEHIIGCGGFGTVYKLAMDDGKVFALKRILKLNEGFDRFFERELEILGSIKHRYLVNLRGYCNSPTSKLLLYDYLPGGSLDEALHVERGEQLDWDSRVNIIIGAAKGLSYLHHDCSPRIIHRDIKSSNILLDGNLEARVSDFGLAKLLEDEESHITTIVAGTFGYLAPEYMQSGRATEKTDVYSFGVLVLEVLSGKRPTDASFIEKGLNVVGWLKFLISEKRPRDIVDPNCEGMQMESLDALLSIATQCVSPSPEERPTMHRVVQLLESEVMTPCPSEFYDSSSD
Protein: Protein sprouty homolog 2 (Spry-2) (Q9QXV8)
Organism: Mus musculus (Mouse)
Function: Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells. Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O43597}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O43597}. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). {ECO:0000250|UniProtKB:O43597}.
Interaction partners:
- E3 ubiquitin-protein ligase CBL
- Growth factor receptor-bound protein 2
- Serine/threonine-protein kinase B-raf
- Tyrosine-protein phosphatase non-receptor type 11
- Dual specificity protein phosphatase 6
- Epidermal growth factor receptor
- E3 ubiquitin-protein ligase SIAH2
- E3 ubiquitin-protein ligase CBL-B
- SH3 domain-containing kinase-binding protein 1
Sequence:
MEARAQSGNGSQPLLQTAHDSGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQPSQVHSSRAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGPSFSHGPAAADGIIRVQPKSELKPGDVKPLSKDDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT
Protein: von Willebrand factor (vWF) (Q62935)
Organism: Rattus norvegicus (Rat)
Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).
Subcellular location: Secreted {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Localized to storage granules. {ECO:0000250}.
Interaction partners:
- Platelet glycoprotein Ib alpha chain
- Coagulation factor VIII
- Integrin subunit alpha 2b
- P-selectin
- Platelet glycoprotein Ib beta chain
- Glycoprotein 9
- Platelet glycoprotein V
- Coagulation factor X
- Glycoprotein VI
- Aa1018
Sequence:
HCDGVNLTCEACQEPGGLVVPPTDAPVSSTTPYVEDTPEPPLHNFYCSKLLDLVFLLDGSYRLSEAEFEVLKAFVVGTMERLHISQKRIRVAVVEYHDGSHAYLELRARKRPSELRRIASQIKYVGSQLASTSEVLKYTLFQIFGKIDRPEASRVILLLTASQEPQRMARYFTRYLQGFKKKKVILIPVGIGPHANLKQIRLIEKQAPENKAFLLSGVDELEQRRDEIINYLCDLAPEAPAPSKPPQVAHITVSPGISGVSSPGPKRKSLVLDVVFVLEASDEVGEANFNKSKEFLEEVIQRMDVSPAGTHIAVLQYSYTVNVEYTFKEAQSKEDVLRHVREIRYQGGNRTNTGQALQYLSEHSFSPSQGDREQAPNLVYMVTGNPASDEIRRLPGDIQVVPIGVGSRANLQELERISRPITPIFIQDFE
Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (Q90754)
Organism: Gallus gallus (Chicken)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MTRLRVCERLLGAYLLIILHVQGQNLDSMLHGTGMKTNPDQKKQGNGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDEHGEPTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTDFCNQDLQPTLPPLDSTDGLFDGSIRWMAVLISMAVCIIVMIILFSCFCYKHYCKSMAKRHCYNRDLEQDEAFIPAGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKLFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCTTLDNRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCVTGGIVEEYQLPYYDMVPNDPSYEDMREVVCVKRLRPVVSNRWNSDECLRAILKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
Protein: Homeobox protein unc-39 (Homeobox protein ceh-35) (Uncoordinated protein 39) (O17894)
Organism: Caenorhabditis elegans
Function: Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons. Specifically, plays a role in the terminal differentiation of RID peptidergic neurons. Also required for CAN neuron axon guidance.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15282156}.
Interaction partners:
- Protein phosphatase eya-1
- Paired domain-containing protein
Sequence:
MTDHPPIDTSSYFDCYQQHQLPLQYTFTSSSNSNTSNSSTSPSHISDQFSSSGGPPYELSSHILTPSSVIPTPSPSVASASISSPTIPAFGCTMSEYSMEQMEAISTSLFQARDGDRLVAFFKQLESLYGPNAVDHLRSEAIIVAYTYALYHSNEFETLFHLLSNRHFQQRHYNDLQDIWHHARYKESQLKRGKELNPVEKYRLRRKFPAPKTIWDGEEIVYSFKDSSRKFLKQFFRNVSEYPTQEQKREISRATGLKIVQISNWFKNRRQRDKSNNSAKCSPPSSSSSTNGGSDFLPIITPQSFNLAAAPFNMNMIYGTLRDSQSDNDQFTFNP
Protein: Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) (O95466)
Organism: Homo sapiens (Human)
Function: May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19815554}; Lipid-anchor {ECO:0000269|PubMed:19815554}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions.
Interaction partners:
- Cell division control protein 42 homolog
- Protein Cripto
- SLIT-ROBO Rho GTPase-activating protein 2
- Profilin-1
- Cryptic protein
- Profilin-4
- Profilin-3
- SLIT-ROBO Rho GTPase-activating protein 3
- Ras-related C3 botulinum toxin substrate 1
- Transforming protein RhoA
Sequence:
MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGPSRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKTVPFTARTGKRTSRLLCEASLGEEMPL
Protein: Genome polyprotein (Q8UZC1)
Organism: Foot-and-mouth disease virus serotype O (FMDV)
Subcellular location: Host cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004295}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004625}. Host nucleus {ECO:0000256|ARBA:ARBA00004147}. Virion {ECO:0000256|ARBA:ARBA00004328}.
Interaction partners:
Sequence:
MNTTDCFIALVQAIREIKALFLPRTTGKMELTPYNGEKKTFYSRPNNHDNCWLNAILQLFRYVEEPFFDWVYSSPENLTLEAIKQLEDLTGLELHEGGPPALVIWNIKHLLHTGIGTASRPSEVCMVDGTDMCLADFHAGIFLKGQEHAVFACVTSNGWYAIDDEDFYPWTPDPSDVLVFVPYDQEPLNGEWKAKVQRKLKGAGQSSPATGSQNQSGNTGSIINNYYMQQYQNSMDTQLGDNAISGGSNEGSTDTTSTHTTNTQNNDWFSKLASSAFSGLFGALLADKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYATAEDFVSGPNTSGLETRVVQAERFFKTHLFDWVTSDSFGRCHLLELPTDHKGVYGSLTDSYAYMRNGWDVEVTAVGNQFNGGCLLVAMVPELCSIQKRELYQLTLFPHQFINPRTNMTAHITVPFVGVNRYDQYKVHKPWTLVVMVVAPLTVNTEGAPQIKVYANIAPTNVHVAGEFPSKEGIFPVACSDGYGGLVTTDPKTADPVYGKVFNPPRNQLPGRFTNLLDVAEACPTFLRFEGGVPYVTTKTDSDRVLAQFDMSLAAKHMSNTFLAGLAQYYTQYSGTINPHFMFTGPTDAKARYMIAYAPPGMEPPKTPEAAAHCIHAEWDTGLNSKFTFSIPYLSAADYAYTASDVAETTNVQGWVCLFQITHGKADGDALVVLASAGKDFELRLPVDARAETTSAGESADPVTTTVENYGGETQIQRRQHTDVSFIMDRFVKVTPQNQINILDLMQIPSHTLVGALLRASTYYFSDLEIAVKHEGDLTWVPNGAPEKGLDNTTNPTAYHKAPLTRLALPYTAPHRVLATVYNGECRYSRNAVPNVRGDLQVLAQKVVRTLPTSFNYGAIKATRVTELLYRMKRAETYCPRPLLAIHPTEARHKQKIVAPVKQTLNFDLLKLAGDVESNPGPFFFSDVRSNFSKLVETINQMQEDMSTKHGPDFNRLVSAFEELAIGVKAIRTGLDEAKPWYKLIKLLSRLSCMAAVAARSKDPVLVAIMLADTGLEILDSTFVVKKISDSLSSLFHVPAPVFSFGAPILLAGLVKVASSFFRSTPEDLERAEKQLKARDINDIFAILKNGEWLVKLILAIRDWIKAWIASEEKFVTMTDLVPGILEKQRDLNDPSKYKEAKEWLDNARQACLKSGNVHIANLCKVVAPAPSKSRPEPVVVCLRGKSGQGKSFLANVLAQAISAHFTGRTDSVWYCPPDPDHFDGYNQQTVVVMDDLGQNPDGKDFKYFAQMVSTTGFIPPMASLEDKGKPFNSKVIIATTNLYSGFTPRTMVCPDALNRRFHFDIDVSAKDGYKINNKLDIIKALEDTHTNPVAMFQYDCALLNGMAVEMKRMQQDMFKPQPPLQNVYQLVQEVIDRVELHEKVSSHPIFKQISIPSQKSVLYFLIEKGQHEAAIEFFEGMVHDSIKEELRPLIQQTSFVKRAFKRLKENFEIVALCLTLLANIVIMIRETRKRQKMVDDAVNEYIEKANITTDDKTLDEAEKSPLETSGASTVGFRERTLPGQKACDDVNSEPAQPVEEQPQAEGPYAGPLERQKPLKVRAKLPQQEGPYAGPMERQKPLKVKAKAPVVKEGPYEGPVKKPVALKVKAKNLIVTESGAPPTDLQKMVMGNTKPVELILDGKTVAICCATGVFGTAYLVPRHLFAEKYDKIMLDGRAMTDSDYRVFEFEIKVKGQDMLSDAALMVLHRGNRVRDITKHFRDTARMKKGTPVVGVINNADVGRLIFSGEALTYKDIVVCMDGDTMPGLFAYRAATKAGYCGGAVLAKDGADTFIVGTHSAGGNGVGYCSCVSRSMLLKMKAHIDPEPHHEGLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGVVLDEVIFSKHKGDTKMSEEDKALFRRCAADYASRLHSVLGTANAPLSIYEAIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLMEKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFCAQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCSDAMNIMFEEVFRTEFGFHPNAEWILKTLANTEHAYENKRITVEGGMPSGCSATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDFEALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYKPVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLFEIPSYRSLYLRWVNAVCGDA
Protein: Uncharacterized protein (Q581R6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MPENPQRRDGAGNEVEPVPPLEGNVETSAPDAAEECQTSSTPTEAVIMLDEPCRNLPKLHWQDFKLIGRCISFLGESVVNDETLFLHYEGYVSMVNKNTITLLNVNRFTSDDFLKRRERLEQEKTKRNARREVKAQEGSSKEDEKDIVTRENIWGENNGSTEEVDESGVASGAPADENNRRSMFLSLFYVNSRRGKGDAETQSERQKLICGAGSIGPIPYVTFARSAIHDVVVGNDQRSSFMSIFRHSSKKFFDMQCLRMYVRRFLVSASRENKEQSLTLRSFVESKCNYKGIDDNVLVSVAKEELAALANIDKNIAKCSSRPTDARVGIQLQLFRAPPGLFSGTGILFLTRLPMQTFWLAVVQSLMTLMLLTVAANTFIGGRNGIVNGYMFRYISPILIGCFHCLFASAVTAFHAIRMRMPVRFSPHAMLRAAAVGIAIGFCSLALLAVAEAISFPRIQSYIRERAEDPIALCAYYKSNECRGYNENCDVDRDSPTCLWGVCKGEWKGAPCTRKLNRTIVMGFVPFGVLSILLFGMFVIDGFLHYRLFRVSRLIAAITSR
Protein: C-C chemokine receptor type 5-like (Chemokine (C-C motif) receptor 2) (F1QYD4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MTEEPSTVAATKTDYSDYYNEEGDFEQPCNNGQTKAFSEVFLPTLYSIVFIIGFIGNGLVVWVLVRYRHKSNMTDVCLFNLALADLLFLVSLPFWAHNAMDEWIFGRFMCHTITGLFMIGLYASIFFMVLMTLDRYAIIVHAHSVFSRNRSTKMGLALASLVWMLSLLVSLPNIIFAKDKNETNSKISCGSDFPKDSSWMPFTYLKMNLLSLVFPLIIMIFCYSRIIPTLLSMKSQKKHKVVRLILAVVAVYFIFWTPYNIVMFLMFLQKMEYMLTCEWHNGLSLAMQWVETIALSHCCLNPIIYAFAGEKFRGAVIKVLNDQFPMCFKQCASFTHQLSERRSSMFSRSSEISSTQIA
Protein: S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) (Q1RMZ1)
Organism: Homo sapiens (Human)
Function: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).
Interaction partners:
- KICSTOR subunit 2
- KICSTOR complex protein ITFG2
- KICSTOR complex protein SZT2
- GATOR1 complex protein NPRL2
- GATOR1 complex protein DEPDC5
- KICSTOR complex protein kaptin
- GATOR1 complex protein NPRL3
- Ras-related GTP-binding protein A
- Cytosolic arginine sensor for mTORC1 subunit 1
- Sestrin-2
Sequence:
MEPGAGGRNTARAQRAGSPNTPPPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDEETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNMHESSQLEGHLTNLSFTNPEFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDPILLLS
Protein: Potassium channel regulatory protein (Potassium channel regulator) (Protein CLLD4) (Q8N5I3)
Organism: Homo sapiens (Human)
Function: Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:19968958}.
Interaction partners:
- E3 ubiquitin-protein ligase TRIM13
- Ubiquitin-like protein FUBI
Sequence:
MSSQELVTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQEFKMVGGQIFVDRDGDLFSFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLNPYLLQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFTEQPSAPTWNGNFFPPQMTLLPLPPQRPSYHDLVFQCGSDSTTDNQTGVRYVSIKPDNRKLANGTNVLGLLIDTLLKEGFHLVSTRTVSSEDKTECYSFERIKSPEVLITNETPKPETIIIPEQSQIKK
Protein: Elongation factor 3 (EF-3) (EC 3.6.4.-) (Eukaryotic elongation factor 3) (eEF3) (O93796)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Ribosome-dependent ATPase that functions in cytoplasmic translation elongation (By similarity). Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P16521}.
Interaction partners:
- Candida glabrata strain CBS138 chromosome D complete sequence
- Candida glabrata strain CBS138 chromosome L complete sequence
- Candida glabrata strain CBS138 chromosome L complete sequence
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL3
- Candida glabrata strain CBS138 chromosome G complete sequence
- Candida glabrata strain CBS138 chromosome M complete sequence
- RP21
- RP21
- Small ribosomal subunit protein uS5
Sequence:
MTDSDQSLKVLEELFKNLSVATADNRVEAAQEVASFLNGNIIEHDIPEKFFEELAKAVKDKKTSANFLEAVAHIANEANLSPSVEPFVITLVPEICAKAGDKDKDVQAVASKTLVAISKAINPVAIKAYLPHLTKSLETTNKWQEKVSVLAAISALVDAAKEQVALRMPELIPVLSETMWDTKKEVKEAATATMTKATETVDNKDIERFIPQLISCIADPKQVPETVHLLGATTFVAEVTPATLSIMVPLLSRGLAERETSIKRKAAVIIDNMCKLVEDPQVVAPFLDKLLPGLKNNYATIADPEAREVTLRGLKTLRRVGNVTEDDVLPEISHAGDIETTLGVINELLKGENVAPRFKIVVEYIAAMAGDLIDERVIDQQAWFTHITPYMTIFMHERNAKDVLDEFRKRAVDNIPVGPNFDDEEDEGEDLCNCEFSLAYGAKILLNKTQLRLKRGRRYGLCGPNGAGKSTLMRAIANGQVDGFPTPEECMTVYVEHDIDGTHADTSVLDFVVSSEVGTKEAITAKLVEFGFTEEMINMPISSLSGGWKMKLALARAVLKNADILLLDEPTNHLDTVNVAWLVNYLNTCGITSVIVSHDSGFLDNVCQYIIHYEGLKLRKYKGNLSEFVKKCPTAQSYYELGASDLEFKFPEPGYLEGVKTKQKAIVKVSNMTFQYPGTSKPQISDISFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHENCRIAYIKQHAFAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIFKIEGTPRRIAGIHARRKFKNTYEYECSFLLGENIGMKSERWVPMMSVDNAWIPRGELVESHSKMVAEVDMKEALASGQFRPLTRKEIEEHCAMLGLDAELVSHSRIRGLSGGQKVKLVLAACSWQRPHLIVLDEPTNYLDRDSLGALSKALKAFEGGVIIITHSAEFTKNLTEEVWAVKDGKMTPSGHNWVSGQGAGPRIEKKEDEEDKFDAMGNKIAGGKKKKKLSSAELRKKKKERMKKKKELGDAYVSSDDEDF
Protein: cAMP-responsive element-binding protein-like 2 (O60519)
Organism: Homo sapiens (Human)
Function: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Transcription factor ETV6
- CREB3 regulatory factor
Sequence:
MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIKALLTGEEQNKSQQNSSRHTKAGKTDANSNSW
Protein: CBL-interacting serine/threonine-protein kinase 15 (EC 2.7.11.1) (SNF1-related kinase 3.1) (SOS-interacting protein 2) (SOS2-like protein kinase PKS3) (Serine/threonine-protein kinase ATPK10) (P92937)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
Interaction partners:
- Calcineurin B-like protein 1
- Calcineurin B-like protein 4
- Calcineurin B-like protein 9
- Protein phosphatase 2C 77
Sequence:
MEKKGSVLMLRYEVGKFLGQGTFAKVYHARHLKTGDSVAIKVIDKERILKVGMTEQIKREISAMRLLRHPNIVELHEVMATKSKIYFVMEHVKGGELFNKVSTGKLREDVARKYFQQLVRAVDFCHSRGVCHRDLKPENLLLDEHGNLKISDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVISRNGYDGFKADVWSCGVILFVLLAGYLPFRDSNLMELYKKIGKAEVKFPNWLAPGAKRLLKRILDPNPNTRVSTEKIMKSSWFRKGLQEEVKESVEEETEVDAEAEGNASAEKEKKRCINLNAFEIISLSTGFDLSGLFEKGEEKEEMRFTSNREASEITEKLVEIGKDLKMKVRKKEHEWRVKMSAEATVVEAEVFEIAPSYHMVVLKKSGGDTAEYKRVMKESIRPALIDFVLAWH
Protein: Tat-binding homolog 7 (Lin-48 expression abnormal protein 1) (P54816)
Organism: Caenorhabditis elegans
Function: Thought to form a complex that enhances transcription from repetitive DNA sequences by modulating chromatin structure.
Interaction partners:
- FACT complex subunit spt-16
- Probable glycerol-3-phosphate dehydrogenase, mitochondrial
- Glycerol-3-phosphate dehydrogenase
- Splicing factor 3A subunit 2
- RING-type domain-containing protein
- Rho-GAP domain-containing protein
Sequence:
MPRSDGFSPRKNLRRSARDHSRSYAGQCNEDFDDMYAPSSRRRSSGGVDGNGYTRSGRKINHNRYYEEEYHEAISSEEDERRYRTRRSSNSMTYRQQVMQAIDESKRNQKVPPAKRKRIYLSDEEEEDFAEAAHVENTVPERATRRSTRRRSSMHEELGVSEQEESPVRRTRKAAKRLGSEQPEENLAADDPLPMEGGGEIVLPIAEIDGMAEQENEDLIEKIGREEEEEGAEEDEQSGEKDPEEEEDDSSNAESSEESTAPRQYSLRRRQPVVQFNASEARENRRARLEHHRVANQNRHHRNRNGSRRRRSDSDSDSDDMVLPRPDKRQSRPHMHNRGERERGRFMPINMTEKELQSAQHILMDRMRKTDAGQGASDIDPMSVDSSVGFDQVGGLGHHIQSLKEVVLFPMLYPEVFEKFRINPPKGVVFYGPPGTGKTLVARALANECRRGANKVAFFMRKGADCLSKWVGESERQLRLLFDQAYAMRPSIIFFDEIDGLAPVRSSKQDQIHASIVSTLLALMDGLDGRGEVVVIGATNRLDTLDPALRRPGRFDRELRFSLPDLNARRQILDIHTSKWEENKPIPETLDAIAERTSGYCGADLKFLCTEAVLIGLRSRYPHIYMCSERLKLDVATIKITSEHFGHAMRRITPASRRDLTIPSRPLDERTSILLGDTVSNLISLRIPQGYRCVENAMATASSELEQVVRALEPNPTVPAIRLLLCGSEQLADGGQTSYVLPAILAKLDHLPVFSLSVSSLLTDGRPEEAFSNAIQSAMRASATGPCIMLLPSIDEWIKVIPVSVQHMLITCLESMTGFTPILFLSTLDTSFEDAPEYVTEIFRHANCITLNPSRRTIRQKYFEHVIEKINTPPKVFDPTVYEMPLPDDDSPDSKPSRKLNDDETRELLKMYTALQRQMRLFFKERLTRLMRDRRFVEFVEPVDPDEAEDYYEIIETPICMQDIMEKLNNCEYNHADKFVADLILIQTNALEYNPSTTKDGKLIRQMANTLRDAIDDLIECELDESFVERIETVSRMLQDAGVTPTSDKLLTEIPKGFARKKAWSMTNSLAKEIEQWTSEREAENQKMLSKLGVAAPTLELVVVPVEDMKSEEGTSTSTDGVPASAGNKKKLLKKKKGQKKSKTGESEEHDEDSTVEDAGEDTIVENLEIKKNQETPNSEHDIEMKDASKDSTPSVQISIAEKELIVSKPATCELIQCCVEKSEGWSVSELERLSSVLSHTIERFRDEWNRENLPAQLTQIVREWQTADDSNNTIVNGTLNKSNGNLANGH
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Q6PC53)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Histone H2A.V
- Histone H2A
- Ran-specific GTPase-activating protein
- Histone H2A
- Histone H2A
- Histone H2A
- Histone H2A
- Histone H2A
- Histone H2AX
- Core histone macro-H2A
Sequence:
MANPKVFFDITIDGKEAGRIVMELRADVVPKTAENFRALCTGEKGFGYKGSGFHRVIPQFMCQGGDFTNHNGTGGKSIYGNKFEDENFTLKHGGKGTLSMANAGPNTNGSQFFICTADTNWLDGKHVVFGKVVDGLDVVDAIEKKGSSSGKCSAKVVIANCGQL
Protein: Apolipoprotein B-editing catalytic subunit 2a (C->U-editing enzyme APOBEC-2a) (Zgc:110762) (Q5CZQ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MADRKGSSGVSSRLSVRRKEKAENDAKKEEKSPTEAEKPEVNGKEVPMENGEAGAAAADGEKPEPIELPPFETITGDRMDPFFFKFQFKNVEYSSGRNKTFLCYLVDHGGEGLMRGYIEDEHAGGHAEEAFFQQILTNYDPACKYTITWYMSSSPCANCATKLAEILRSRKNIRLAIFSSRLFEWEEPEIQAGLKLLASVGCKLRMMKPLDFTYTWDTFVESDEQQFTPWEDCQENYEYYQDKLADILQ
Protein: Zinc finger protein WIP3 (WIP-domain protein 3) (AtWIP3) (Q9SGD1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcriptional regulator.
Subcellular location: Nucleus {ECO:0000269|PubMed:20541552}.
Interaction partners:
- SUN domain-containing protein 2
- SUN domain-containing protein 1
- NAI2-like protein
- RAN GTPase-activating protein 1
- Mitotic-spindle organizing protein 1B
- Protein CROWDED NUCLEI 1
- Kinesin-like protein KIN-1
- Vacuole membrane protein KMS2
- TIR domain-containing protein
- Nucleoporin
Sequence:
MNSYETKGLSFESPSFIEWLKPQSSTTSSKSVLYRGKTRDAISRSNHHQSQMNMLERSLFLYQPQEPLNTSIQCLPLLNKLMENNSQASDIKEENKDDVVTLQIGFPKYHRGSSEDGSDITFDHQKKPIKREIIEDGVVMMKKRRKMKFDEEIIDSDVEVCGKRFWIPSPAQIHVGPMQFACSICSKTFNRYNNMQMHMWGHGSEFRKGADSLKGTIQPAAILRLPCYCCAEGCKNNINHPRSKPLKDFRTLQTHYKRKHGSKPFSCGKCGKALAVKGDWRTHEKNCGKLWYCTCGSDFKHKRSLKDHIRSFGSGHSPHPSLLFDGFEEDTECVTTE
Protein: Probable pectinesterase 53 (PE 53) (EC 3.1.1.11) (Pectin methylesterase 53) (AtPME53) (Q8VYZ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular location: Secreted, cell wall {ECO:0000250}.
Interaction partners:
- Probable pectate lyase 20
- Pmr5/Cas1p GDSL/SGNH-like acyl-esterase family protein
- Pectate lyase
- Pectate lyase
- Probable pectate lyase 12
- Probable pectate lyase 5
- Probable pectate lyase 3
- Probable pectate lyase 13
- UDP-rhamnose/UDP-galactose transporter 4
- Probable pectate lyase 4
Sequence:
MPKLNSTQAPNLFLLLLVILLCSTQTQCHTKGLRLRPRNQKNMNTTSDRTQNPEDEFMKWVRFVGSLKHSVFKAAKNKLFPSYTLTVHKKSNKGDFTKIQDAIDSLPLINFVRVVIKVHAGVYKEKVSIPPLKAFITIEGEGAEKTTVEWGDTAQTPDSKGNPMGTYNSASFAVNSPFFVAKNITFRNTTPVPLPGAVGKQAVALRVSADNAAFFGCRMLGAQDTLYDHLGRHYYKDCYIEGSVDFIFGNALSLYEGCHVHAIADKLGAVTAQGRSSVLEDTGFSFVKCKVTGTGVLYLGRAWGPFSRVVFAYTYMDNIILPRGWYNWGDPSREMTVFYGQYKCTGAGANYGGRVAWARELTDEEAKPFLSLTFIDGSEWIKL