wanglab/gogpt-training-data huggingface dataset:
Protein: pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) (Q8K4P0)
Organism: Mus musculus (Mouse)
Function: Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.
Subcellular location: Nucleus {ECO:0000269|PubMed:11162572}.
Interaction partners:
- Cleavage and polyadenylation specificity factor subunit 4
- Cleavage and polyadenylation specificity factor subunit 3
- Pre-mRNA 3'-end-processing factor FIP1
- Cleavage and polyadenylation specificity factor subunit 2
- Symplekin
- Cleavage and polyadenylation specificity factor subunit 1
- WD repeat-containing protein 82
- E3 ubiquitin-protein ligase RBBP6
- Cleavage stimulation factor subunit 3
- RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Sequence:
MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESSEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQADQIQPPPSSGTPLLGPQPFSGQGPISQIPQGFQQPHPSQQMPLVPQMGPPGPQGQFRAPGPQGQMGPQGPPMHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPASQGHMGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPASQGIQGPLMGLNPRGMQGPPGPRENQGPAPQGLMIGHPPQEMRGPHPPSGLLGHGPQEMRGPQEMRGMQGPPPQGSMLGPPQELRGPSGSQGQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKAPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDTRGPPNHHLGPMSERRHEQSGGPEHGPDRGPFRGGQDCRGPPDRRGSHPDFPDDFRPDDFHPDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFNEGDGRGAARGPPGAWEGRRPGDDRFPRDPDDPRFRGRREESFRRGAPPRHEGRAPPRGRDNFPGPDDFGPEEGFDASDEAARGRDLRGRGRGTPRGGSRKCLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDAPRPDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGSGTSEHREMEAQGGPSEDRGSKGRGGPGPSQRVPKSGRSSSLDGDHHDGYHRDEPFGGPPGSSSSSRGARSGSNWGRGSNMNSGPPRRGTSRGSGRGR
Protein: Structural maintenance of chromosomes protein 5 (M9PGC9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAGDRALSSKQLAGRIHSVYCKDFVSYSEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYIQSNKTSATIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANVHANREKEKSDLVKKQKRLEHLQMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKTRLLENAVAEKAAIDGKMDSLKQGIYQKKYELEQNIKKSRRTATECDNLNQLVENKIYELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQKLNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFVVTASRYRSDTILTESSIRAKNQLITVDSQQLALVMKQCSEAVKESDSIKNAITQTDNEFERLQAVAKDEQEKRRKLDQKIAHFNSLKTEIETLQKKLEALRNSDSLDCLETNFCNSLHKDLKKIFDADAELCSCLKAIDRLIIEKNMAQTKVSIYMLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFPFKKEFRELENIDLPELREAIHDFQARLECMKSVNSEAISSYQGLQNEVKQLEEGIQESVNQAKSIESGMSNLYDKWEPKLNSLVETISTKFSEFMESIEYVGEVVLSKTDKIMVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVTPKLLRDLNYNEHLCVSIVHNSKTVCHGMQFPMA
Protein: Transmembrane protease serine 2 (EC 3.4.21.122) (Epitheliasin) (Plasmic transmembrane protein X) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain] (Q9JIQ8)
Organism: Mus musculus (Mouse)
Function: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption (By similarity). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O15393}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O15393}.; SUBCELLULAR LOCATION: [Transmembrane protease serine 2 catalytic chain]: Secreted {ECO:0000250|UniProtKB:O15393}. Note=Activated by cleavage and secreted. {ECO:0000250|UniProtKB:O15393}.
Interaction partners:
- Angiotensin-converting enzyme 2
- Transmembrane protease serine 4
- Androgen receptor
- Furin
- ETS translocation variant 1
- Disintegrin and metalloproteinase domain-containing protein 17
- Procathepsin L
- CD9 antigen
- Dipeptidyl peptidase 4
- Transcriptional regulator ERG
Sequence:
MALNSGSPPGIGPCYENHGYQSEHICPPRPPVAPNGYNLYPAQYYPSPVPQYAPRITTQASTSVIHTHPKSSGALCTSKSKKSLCLALALGTVLTGAAVAAVLLWRFWDSNCSTSEMECGSSGTCISSSLWCDGVAHCPNGEDENRCVRLYGQSFILQVYSSQRKAWYPVCQDDWSESYGRAACKDMGYKNNFYSSQGIPDQSGATSFMKLNVSSGNVDLYKKLYHSDSCSSRMVVSLRCIECGVRSVKRQSRIVGGLNASPGDWPWQVSLHVQGVHVCGGSIITPEWIVTAAHCVEEPLSSPRYWTAFAGILRQSLMFYGSRHQVEKVISHPNYDSKTKNNDIALMKLQTPLAFNDLVKPVCLPNPGMMLDLDQECWISGWGATYEKGKTSDVLNAAMVPLIEPSKCNSKYIYNNLITPAMICAGFLQGSVDSCQGDSGGPLVTLKNGIWWLIGDTSWGSGCAKALRPGVYGNVTVFTDWIYQQMRANS
Protein: Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Estrogen receptor-binding cyclophilin) (Rotamase D) (P26882)
Organism: Bos taurus (Bovine)
Function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q08752}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q08752}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q08752}.
Interaction partners:
- ADP/ATP translocase 4
- Non-selective voltage-gated ion channel VDAC1
- ADP/ATP translocase 1
- ADP/ATP translocase 3
- ADP/ATP translocase 2
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Non-selective voltage-gated ion channel VDAC2
- Non-selective voltage-gated ion channel VDAC3
- Prostaglandin E synthase 3
- Activator of 90 kDa heat shock protein ATPase homolog 1
Sequence:
MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKEGLLSMANAGSNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVAKILENVEVKGEKPAKLCVIAECGELKEGDDWGIFPKDGSGDSHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKEKAAYAKMFA
Protein: Assimilatory nitrite reductase small subunit (Q9I2W2)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Assimilatory nitrite reductase large subunit
- nitrate reductase
- Nitrate/nitrite transporter
- nitrate reductase
- nitrate reductase
- nitrate reductase
- Nitrate/nitrite transporter
- Periplasmic nitrate reductase
- Nitrite extrusion protein 1
- Periplasmic nitrate reductase, electron transfer subunit
Sequence:
MNWLDICSLDEINPLGSRVVAGPKGDIAIFRAADDQVFALDDRCPHKGGPLSQGLIYGKRVACPLHNWQIELESGEAVAPDQGCAHRHPVRVENGRVLLGLDSVALCA
Protein: Deoxyhypusine synthase (DHS) (EC 2.5.1.46) (Q6AY53)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Interaction partners:
- Eukaryotic translation initiation factor 5A-1
- Eukaryotic translation initiation factor 5A
- Deoxyhypusine hydroxylase
- S-adenosylmethionine decarboxylase proenzyme
- Ornithine decarboxylase
Sequence:
MEGTPSGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLEAYGTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHEDLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVQEQNTEGVKWTPSKMISRLGKEINNPESVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINMQAIFAKRTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKADAFRAEKNED
Protein: Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) (Q6P9F7)
Organism: Homo sapiens (Human)
Function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:24790029}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000269|PubMed:24790029}.
Interaction partners:
- Volume-regulated anion channel subunit LRRC8A
- Volume-regulated anion channel subunit LRRC8D
- Volume-regulated anion channel subunit LRRC8C
Sequence:
MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKVEFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTCLDKC
Protein: Protein transport protein SEC24 A (AtSec24A) (Protein G92/ENDOPLASMIC RETICULUM MORPHOLOGY 2) (Q9SFU0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein. Component of the coat protein complex II (COPII), that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII is composed of at least five proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1 (By similarity). Acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. Involved in maintaining the dynamic identity of organelles of the early secretory pathway. Regulates cell size patterning, and prevents CDKA;1-, DEK1- and ACR4-dependent endoreduplication and giant cells formation in sepals. Required for male gametophytes (pollen grains) development and transmission.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:O95486}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95486}; Cytoplasmic side {ECO:0000250|UniProtKB:O95486}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O95486}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95486}. Golgi apparatus membrane {ECO:0000269|PubMed:19933202}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95486}. Cytoplasm, cytosol {ECO:0000269|PubMed:19933202}.
Interaction partners:
- Protein transport protein SEC13 homolog A
- Protein transport protein SEC31 homolog A
- Protein transport protein SEC13 homolog B
- Protein transport protein SEC31 homolog B
- Protein transport protein SEC23 B
- Protein transport protein SEC23
- Protein transport protein SEC24 C
- Protein transport protein SEC24 B
- Protein transport protein SEC23
- Protein transport protein SEC23 C
Sequence:
MGTENQGYPNFPARPASSPFASAPPPGIPPQSGGPPTGSEAVGFRPFTPSASQPTRPFTASGPPPAPPVGTMRPGQPSPFVSQIPGSRPPPPSSNSFPSPAYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLSPPMSLRPQQPMAPVAMGPPPQSTTSGLPGANAYPPATDYHMPARPGFQQSMPPVTPSYPGVGGSQPSFPGYPSKQVLQAPTPFQTSQGPPGPPPVSSYPPHTGGFAQRPNMAAQQNLHPNYAPPPSNVQGLTEDFNSLSLSSIPGSLEPGLDHKSFPRPLDGDVEPNSFAEMYPMNCHSRYLRLTTSAIPNSQSLASRWHLPLGAVVCPLAETPEGEEVPLIDFGSTGIIRCRRCRTYVNPFVTFTDSGRKWRCNICSMLNDVPGEYFSHLDATGRRMDMDQRPELTKGSVEIIAPTEYMVRPPMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPGYPRTQIGFITYDSTLHFYNMKSSLSQPQMMVVSDLDDIFVPLPDDLLVNLSESRTVVDAFLDSLPLMFQDNFNVESAFGPALRAAFMVMNQLGGKLLIFQNSLPSLGAGRLKLRGDDPRVYGTDKEYALRVAEDPFYKQMAADCTKFQIGINVYAFSDKYTDIASLGTLAKYTGGQVYYYPGFQSSVHGDKLRHELARDLTRETAWEAVMRIRCGKGIRFSSYHGNFMLRSTDLLALPAVDCDKAYAMQLSLEETLLTSQTVYFQVALLYTASCGERRIRVHTSVAPVVTDLGEMYRQADTGSIVSLYARLAIEKSLSAKLDDARNAIQQKIVKALKEYRNLHAVQHRLGSRLVYPESLKFLPLYGLAITKSTPLLGGPADTSLDERCAAGFTMMALPVKKLLKLLYPNLFRVDEWLLKPSAAHDDFKDVLRRLPLAAESLDSRGLYIYDDGFRLVLWFGRMLSPDIAKNLLGVDFAADLSRVTFQEQENGMSKKLMRLVKKLRESDPSYHPMCFLVRQGEQPREGFLLLRNLIEDQMGGSSGYVDWILQLHRQVQQN
Protein: Ribosome assembly protein 1 (EC 3.6.5.-) (EF-2 like GTPase) (Elongation factor-like 1) (O74945)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with sdo1, may trigger the GTP-dependent release of tif6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating tif6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Inhibits GTPase activity of ribosome-bound EF-2 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Ribosome maturation protein sdo1
- Putative ribosomal recycling factor
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein bL12m
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL29
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS9m
Sequence:
MPVIPPEKLVSLQKNQENIRNFTLLAHVDHGKTTLADSLLASNGIISSKLAGTVRFLDFREDEITRGITMKSSAISLFFKVISQNDEKRVEKDYLINLIDSPGHVDFSSEVSSASRLCDGAFVLVDAVEGVCSQTITVLRQAWIDRIKVILVINKMDRLITELKLSPIEAHYHLLRLVEQVNAVIGTFYTGELMQLADNDEVISDEGIYFAPEQGNVVFASAYDGWAFCLDQFSEFYEKKLGLKQKALTKCLWGDYYLDPKTKRVLQPKHLQGRRLKPMFVQFVLENLWAVYESAVSNRNLENIEKIIKALNIKVLPRDIKSKDPRNLLLAIFQQWLPLSTAILLTAIREIPSPINAQANRARKVLSSTPHYEMIDPDITLAMESCDASKEQPVLVYISKMVAFSERDLPNHRRKQLSAEEMKLIRSKLSESIESGINTISIEENVSSTNSDNLEGSTTDMDDDKDILIGFARIYSGTISVGQEVYVYGPKYDPVNPEKHITKVTVESLYLMMGQELVYLETVPAGNVFAIGGLAGTVLRTATLCSSPNGPNLVGVTQQMEPIVRVALEPVRPFEMNKLVTGLDMLNQADPCVQIAVEENGEHVIMCAGEIHLERCLKDLRERFAKIEIQASQPLVPYRETTIATPDLLAKNKELSIGFVTATLPVGGVTIGITVTPLSGSVVDFLLKHSKTIENVSSNFSKKNRNVVVSESLTKSMEEVLTPEKFYERLSKLLEEENSDLGELKNHLDSIIAFGPKRVGPNILFDKTKKMRDFRRQSDETKLIPSDLSEYVVTAFQLITHQGPLCAEPVQGICVSIDQFDISDDSEDSKLLTINNPQIPGQVISVVKESIRHGFLGWSPRLMLAMYSCDVQATSEVLGRVYGVVSKRRGRVIDEEMKEGTPFFIVKALIPVVESFGFAVEILKRTSGAAYPQLIFHGFEMLDENPFWVPTTEEELEDLGELADRENIAKRYMLNVRKRKGLLVEQKIVEKAEKQRTLKH
Protein: ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ) (P15043)
Organism: Escherichia coli (strain K12)
Function: Involved in the RecF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase.
Interaction partners:
- Single-stranded-DNA-specific exonuclease RecJ
- DNA topoisomerase 3
- DNA helicase II
- ATP-dependent DNA helicase RecG
- Single-stranded DNA-binding protein
- Protein RecA
- DNA mismatch repair protein MutL
- Nuclease SbcCD subunit C
- DNA topoisomerase 1
- Holliday junction branch migration complex subunit RuvA
Sequence:
MAQAEVLNLESGAKQVLQETFGYQQFRPGQEEIIDTVLSGRDCLVVMPTGGGKSLCYQIPALLLNGLTVVVSPLISLMKDQVDQLQANGVAAACLNSTQTREQQLEVMTGCRTGQIRLLYIAPERLMLDNFLEHLAHWNPVLLAVDEAHCISQWGHDFRPEYAALGQLRQRFPTLPFMALTATADDTTRQDIVRLLGLNDPLIQISSFDRPNIRYMLMEKFKPLDQLMRYVQEQRGKSGIIYCNSRAKVEDTAARLQSKGISAAAYHAGLENNVRADVQEKFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPADMAWLRRCLEEKPQGQLQDIERHKLNAMGAFAEAQTCRRLVLLNYFGEGRQEPCGNCDICLDPPKQYDGSTDAQIALSTIGRVNQRFGMGYVVEVIRGANNQRIRDYGHDKLKVYGMGRDKSHEHWVSVIRQLIHLGLVTQNIAQHSALQLTEAARPVLRGESSLQLAVPRIVALKPKAMQKSFGGNYDRKLFAKLRKLRKSIADESNVPPYVVFNDATLIEMAEQMPITASEMLSVNGVGMRKLERFGKPFMALIRAHVDGDDEE
Protein: Regulatory protein zeste (Q7JNE1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- IP10578p
- Dorsal interacting protein 4
Sequence:
MNGKMDRRKKRTSSEQYQMYIDMMESDPIFATGRVPRDYDLNYLTKKWKELSDRLNKCSSGPTLTPEEWRKRLNDWKNTTRCKYRRSLLSTEKDISMTSVETRALDLFGKVPTTGGETMLNLKSEKDEHDDEMEELGQRTSVAFQKELQAAVEEAINDEVDEEEMVEEHVDHEDMMEENLAETGITASTTAVNTGGGTYRTIVVDNTSFEHVEEDPQTVQPHAVEYVTSRRPAAPVINPGTASSGNKLINGELPVKRMRTQPREQIIYEVKNAPRCISNMQAVPPLHSTKLEREPSSLTSALSSSDAQQIAHQLKRLADIKFETLQFEIARFKFNNPGFQYDPPSL
Protein: ADP-ribosylation factor-like protein 1 (P40616)
Organism: Homo sapiens (Human)
Function: GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex. Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:11303027}; Peripheral membrane protein {ECO:0000269|PubMed:11303027}; Cytoplasmic side {ECO:0000269|PubMed:11303027}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:27373159, ECO:0000269|PubMed:27436755}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
Interaction partners:
- Golgin subfamily A member 4
- Arfaptin-2
- Brefeldin A-inhibited guanine nucleotide-exchange protein 1
- Short coiled-coil protein
- GRIP and coiled-coil domain-containing protein 2
- Ras-related protein Rab-6A
- Conserved oligomeric Golgi complex subunit 6
- Golgin subfamily A member 1
- GRIP and coiled-coil domain-containing protein 1
- Ras-related protein Rab-6B
Sequence:
MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELRKAILVVFANKQDMEQAMTSSEMANSLGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSRQ
Protein: Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (GP160) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) (Vesicle protein of 165 kDa) (Vp165) (P97629)
Organism: Rattus norvegicus (Rat)
Function: Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity).
Subcellular location: Cell membrane; Single-pass type II membrane protein. Endomembrane system; Single-pass type II membrane protein. Note=Localized mainly in intracellular vesicles together with GLUT4. Relocalizes to the plasma membrane in response to insulin. The dileucine internalization motif and/or the interaction with tankyrases may be involved in intracellular sequestration.
Interaction partners:
- T-cell surface glycoprotein CD4
- Solute carrier family 2, facilitated glucose transporter member 4
- Oxytocin-neurophysin 1
- C-C chemokine receptor type 5
- Insulin-2
- Insulin-1
Sequence:
METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGTCSVPSARTLVICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYHEQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKTLDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL
Protein: Phospholipase C C (PLC-C) (EC 3.1.4.3) (P9WIB1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in virulence. Induces cytotoxic effects on mouse macrophage cell lines, via direct or indirect enzymatic hydrolysis of cell membrane phospholipids. Hydrolyzes phosphatidylcholine. Does not have hemolytic activity.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:20736081}. Note=Remains associated with the cell. {ECO:0000269|PubMed:20736081}.
Interaction partners:
- Phospholipase C B
- Phospholipase C A
- Phosphatidylinositol-3-phosphatase
- Phospholipase C D
- Probable inositol 1-monophosphatase ImpA
- Putative cardiolipin synthase
- Phosphatidylserine decarboxylase proenzyme
- Diacylglycerol kinase
- Inositol-1-monophosphatase SuhB
- Uncharacterized GMC-type oxidoreductase Rv1279
Sequence:
MVSQGAFAGMSRRAFLAKAAGAGAAAVLTDWAAPVIEKAYGAGPCSGHLTDIEHIVLCLQENRSFDHYFGTLSAVDGFDTPTPLFQQKGWNPETQALDPTGITLPYRINTTGGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQARTRSVANTPVVMGYYARPDIPIHYLLADTFTICDQYFSSLLGGTMPNRLYWISATVNPDGDQGGPQIVEPAIQPKLTFTWRIMPQNLSDAGISWKVYNSKLLGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDFIRDVINNTLPQVSWVVPLTVESEHPSFPVAVGAVTIVNLIRVLLRNPAVWEKTALIIAYDEHGGFFDHVTPLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPIGLGFRVPCFVISPYSRGGLMVHDRFDHTSQLQLIGKRFGVPVPNLTPWRASVTGDMTSAFNFAAPPDPSPPNLDHPVRQLPKVAKCVPNVVLGFLNEGLPYRVPYPQTTPVQESGPARPIPSGIC
Protein: Uncharacterized protein (F4K940)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MPGTIQVSVLGLIDVQTSSPGSSNTSIKVAMGKLEYQTSDSGDYIFPVTRLRENLIVTLLDVNGNQILQKEIETRMIIESGFLEEKLSFNGYGNVQLKMQFVLSEEDRNRIRFLRQSALRKKHEELVNGSSFTKSKSIASDLSSLSSMQSRDIVAVASSKTNLGLSQETKLKTNADRDPVSSNLIMWKPEVKDSVEKTNIQLSSSDVSSSKKVPEVKKLESVSLVKQEDKGLNKPSKKLIEAESVLLVKQEDKGLSKPRKKFTEAKTPESVSLVKQEETGLSKPERKPKRKSMRRSMSDSNLNNVRKMISNFEVKVTQDTKIRTAKIQTDSCKDAEEKTKAQPPAESTVNLEKSEERKIISFNNMEKSVCSDNTDRCDDLVIVSRDERTMDIEDKSLEHSTRRSDLLSTQRRSLVVEVRDDEKKQNKSVWLKDSQLENARGSRLWIFPDEAKDLCCETDLGTRHLDLDLAEANLLQKRIDESTRENIGERGSRCINIAKINSNNKWTNIERSKKQKSENSAESESSGRPVGQVMRALIVVGFAGLVFLTRQ