Protein: DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (Seizure-related protein 4) (Q61493)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mitotic spindle assembly checkpoint protein MAD2B
- DNA polymerase delta subunit 2
- DNA repair protein REV1
- DNA polymerase delta subunit 3
- Fanconi anemia group M protein homolog
- DNA polymerase epsilon catalytic subunit A
- DNA polymerase eta
- DNA primase large subunit
- DNA primase small subunit
- DNA polymerase alpha subunit B
Sequence:
MFSVRIVTADYYMASPLPGLDTCQSPLTQLPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPAMVKRICELLQSGAIMNKCYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKARRKGNASHATGLFKHQLSGNSPAGTLFRWEEDEIPSSLLLEGVEPLSTCELEVDAVAADILNRLDIEAQIGGNPGLQAIWEDEKQRRRNRNESSQISQPESQDCRFVPATESEKQFQKRLQEVLKQNDFSVTLSGSVDYSNGSQEFSAELTLHSEILSPEMLPCSPANMIEVHKDTDLSKGNTKHKVEEALINEEAILNLIENSQTFQPLTQRLSETPVFMGSSPDESLVHLLAGLESDGYQGEKNRMPLPCHSFGESQNPQNSDDEENEPQIEKEEMELSVVMSQRWDSDIEEHCAKKRSLCRNAHRSSTEEDDSSSEEEMEWTDNSLLFANLSIPQLDGTADENSDNPLNNENSRAHSSVIATSKLSVRPSIFHKDAATLEPPSSAKITFQCKHTSALSSHVLNKDGLTEDLSQPNSTEKGRDNSVTFTKESTYSMKYSGSLSSTVHSDNSHKEICKKDKSLPVSSCESSVFDYEEDIPSVTRQVPSRKYSNMRKIEKDASCIHVNRHISETILGKNSFNFADLNHSKRKLSSEGNEKGNSTSLSGVFPSSLTENCDLLPSSGENRSMAHSLESITDESGLNKLKIRYEEFQEHKMEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQSGNKPSRLKLNKKKLIGLQETSTKSTETGATKDSCTHNDLYTGASEKENGLSSDSAKATHGTFENKPPTEHFIDCHFGDGSLEAEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTQNSKISLPHPMEIGENLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKPGKQHRTNSENIKRTLSFRKKRTHAVLSPPSPSYIAETEDCDLSYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIMAAAEKESMLFKGPNVYNTKTVSPRVGKASRARAQVKKSKARLANSSVVTNKRNKRNQTTKLVDDGKKKPRAKQKQRANEKSLSRKHAIPADEKMKPHSEAELTPNHQSVSELTSSSGAQALSKQKEMSQTGPAVDHPLPPAQPTGISAQQRLSNCFSSFLESKKSVDLRTFPSSRDDSHSSVVYSSIGPGISKINIQRSHNQSAMFTRKETTLIQKSIFDLSNHLSQVAQSTQVCSGIISPKTEESSSTQKNCGSSMGKLNEYRSSLESKPEQVCAPNFLHCKDSQQQTVSVSEQSKTSETCSPGNAASEESQTPNCFVTSLKSPIKQIAWEQKQRGFILDMSNFKPEKVKQRSLSEAISQTKALSQCKNQNVSTPSVFGEGQSGLAVLKELLQKRQQKAQSTNVVQDSTSTHQPDKNISVSNEHKKANKRTRPVTSPRKPRTPRRTKPKEQTPRRLKVDPLNLQTSGHLDNSLSDDSPILFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIDKSELLSHDRQSCSEEKHHVSDSSPWIRASTLNPELFEKVAMDNNENHRHSQWKNSFHPLTSHSNSIMESFCVQQAENCLTEKSRLNRSSVSKEVFLSLPQANSSDWIQGHNRKEADQSLHSANTSFTTILSSPDGELVDAASEDLELYVSRNNDVLTPTPDSSPRSTSSPLQSKNGSFTPRTAHILKPLMSPPSREEIVATLLDHDLSEAIYQEPFCSNPSDVPEKPREIGGRLLMVETRLPNDLIEFEGDFSLEGLRLWKTAFSAMTQNPRPGSPLRNGQAVVNKESSNSHKMVEDKKIVIMPCKYAPSRQLVQAWLQAKEEYERSKKLPKTELTPVTKSAENVSPSLNPGDTCAVSPQVDKCPHTLSSSAHTKEEVSKSQIALQTSTTGCSQTLLAAASAAVPEEDEDDNDNCYVSYSSPDSPGIPPWQQAASPDFRSLNGDDRHSSPGKELCSLAVENFLKPIKDGIQKSSCSESWEPQVISPIHARARTGKWDPLCLHSTPVMQRKFLEKLPEATGLSPLSVEPKTQKLYNKKGSDADGLRRVLLTTQVENQFAAVNTPKKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLQPDPEFDPICALFYCISSDTPLPDTEKTELTGVIVIDKDKTVTHQDIRSQTPLLIRSGITGLEVTYAADEKALFQEITNIIKRYDPDILLGYEIQMHSWGYLLQRAAALSVDLCQMISRVPDDKIENRFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSIQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQIRHDVTVSPNGVAFVKPSVRKGVLPRMLEEILKTRLMVKQSMKSYKQDRALSRMLNARQLGLKLIANVTFGYTAANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPRPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKEPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLVEGKASIQDFIFAKEYRGSFSYRPGACVPALELTRKMLAYDRRSEPRVGERVPYVIIYGTPGLPLIQLIRRPAEVLQDPTLRLNATYYITKQILPPLARIFSLIGIDVFSWYQELPRIQKATSSSRSELEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQPQHVAIILNQEIRELERKQEQLIKICRNCTGSFDRHIPCVSLNCPVLFKLSRVNRELSKAPYLRQLLDQF