wanglab/gogpt-training-data huggingface dataset:
Protein: HECT-type E3 ubiquitin transferase (EC 2.3.2.26) (Q9W196)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- 26S proteasome non-ATPase regulatory subunit 14
- Polyubiquitin
- GH17761p
Sequence:
MFGFDGEYRRRPVQSLGGASHTCDRDTVIRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRRKRAEREVFDIYLMGHKDGIVEDESLTFLLRRLNFFYSIREAKDSERLIEVCQQILRQPARLLQHSSPDSLWLLRLCKLLDTCLLQLSLSHTAQAIPLRMLETFTTVSSVQQYMKDEAVLFQYMERVFGFLIARNYFVRLRRLLDDKCPPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPCFALNVDFPFDLLMRSLYDALESAGPAESDSTSSRRSFLFYGVETGHKTTRMDSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDGDDDSEESEDEDEELPAARTLDYDMEQTCRTSGELSVKERECLLESIAILNETERVDFIVQQLDPHIENTHLIYALCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIRAVWFKLAAESTQLGFSAPLTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFELS
Protein: Fe(2+) transport protein 2 (Fe(II) transport protein 2) (Iron-regulated transporter 2) (OsIRT2) (Q6L8G1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Iron transporter that may play a role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16412081}; Multi-pass membrane protein {ECO:0000269|PubMed:16412081}.
Interaction partners:
Sequence:
MMMSSSQTPVRIAFVFLVILAATDAHSDHRTPPPACGGAAVGGECHSVARALRLKLIAIPAILAASVAGVCLPLFARSVPALRPDGGLFAVVKAFASGVILGTGYMHVLPDSFNDLTSPCLPRKPWSEFPFAAFVAMLAAVFTLMVDSLMLTFHTRGSKGRASSAVAHHGDHGHCHAHALGQADVAALSTTEAADQGSGDVEAGNTTKAQLLRNRVIVQVLEMGIVVHSVVIGLGMGASQNVCTIRPLVAALCFHQMFEGMGLGGCILQAGYGGRTRSALVFFFSTTTPFGIALGLALTRVYSDSSPTALVVVGLLNAASAGLLHYMALVELLAADFMGPKLQGNVRLQLAASLAILLGAGGMSVMAKWA
Protein: Mitochondrial carrier protein, putative (Q581R5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Electron transfer protein, putative
- NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial
- NADH-ubiquinone oxidoreductase, mitochondrial, putative
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Acyl carrier protein
- PROP1-like PPR domain-containing protein
- Kinetoplast ribosomal PPR-repeat containing protein 3
- Uncharacterized protein
- 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein
- Mitochondrial import inner membrane translocase subunit TIM22
Sequence:
MGVEVADCSSGASAQNITGSEAMTVGHEKAKEQHMHVKRDSYTTAATFVAGGVAGACSRTLTAPLDRIKIIVQEGHLVSGTGKKSLLRPAQLIDVFHLIRNDGGWSAFWRGNGVNCLKAGPEFALVFTLRRYFLSLYEDSLDEETARVTEWEAAMKATGSEPIAYDLSTVSVLPAPLNRWFTLTSIPRILLNFLIGAWAGFGAQLTLYPLEVIKTRMAVSRRSEYPGGMRQVIYDTYKNSGISGFYRGLTPNMVGIFIYRGLEVGIYSTAQQQMIMYRMNNYGMSRHDSSLSSIETAAVSMFASMFAQTVSYPLNVVRTRLQTQGTNGRAVKYKGMTDCFVKMVRTKGVGSLFSGISANYLKAVPASASMFVVFEKVQSILVGDD
Protein: Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox) (Q62737)
Organism: Rattus norvegicus (Rat)
Function: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P13498}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13498}.
Interaction partners:
- NADPH oxidase 4
- NADPH oxidase activator 1
- NADPH oxidase organizer 1
- NADPH oxidase 2
- NADPH oxidase 1
- Neutrophil cytosolic factor 1
- small monomeric GTPase
- NADPH oxidase 3
- Neutrophil cytosol factor 4
- Polymerase delta-interacting protein 2
Sequence:
MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVLICLLEYPRGKRKKGSTMERCGQKYLTAVVKLFGPLTRNYYVRAVLHLLLSVPAGFLLATILGTVCLAIASVIYLLAAIRGEQWTPIEPKPKERPQVGGTIKQPPTNPPPRPPAEVRKKPSEAEEEAASAGGPQVNPIPVTDEVV
Protein: Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) (Q8IW35)
Organism: Homo sapiens (Human)
Function: Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30375385}. Note=Recruited at the distal end of the mother centriole by MPHOSPH9. {ECO:0000269|PubMed:30375385}.
Interaction partners:
- Centriolar coiled-coil protein of 110 kDa
- Kinesin-like protein KIF24
- Centrosomal protein of 290 kDa
- Neuralized-like protein 4
- Centrosomal protein of 76 kDa
- Centrosomal protein of 104 kDa
- Calmodulin-1
- Protein TALPID3
- Centrosomal protein of 44 kDa
- Centrosomal protein of 164 kDa
Sequence:
MAVARVDAALPPGEGSVVNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQSQNEELSPLVPVETRASLIPEHSSPVQDCQISQESEPVIQVNSWVGINSNDDQLFAVKNNFPASVHTTRYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPLSPTVELRLQGINLGLEDDGVADESVKGLESQVLDKEEEQPLWAANENSVQMMRSEINTEVNEKAGLLPCPEPTIISAILKDDNHSLTFFPESTEQKQSDIKKPENTQPENKETISQATSEKLPMILTQRSVALGQDKVALQKLNDAATKLQACWRGFYARNYNPQAKDVRYEIRLRRMQEHIVCLTDEIRRLRKERDEERIKKFVQEEAFRFLWNQVRSLQVWQQTVDQRLSSWHTDVPPISSTLVPSKHPLFTQSQESSCDQNADWFIASDVAPQEKSLPEFPDSGFHSSLTEQVHSLQHSLDFEKSSTEGSESSIMGNSIDTVRYGKESDLGDVSEEHGEWNKESSNNEQDNSLLEQYLTSVQQLEDADERTNFDTETRDSKLHIACFPVQLDTLSDGASVDESHGISPPLQGEISQTQENSKLNAEVQGQQPECDSTFQLLHVGVTV
Protein: CBY1-interacting BAR domain-containing protein homolog (Protein Fam92) (Q9VK91)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the DZIP1-Fam92-Cby complex which promotes ciliogenesis in sensory neurons and spermatocytes by acting downstream of Cep290 to initiate early ciliary membrane formation and thus transition zone (TZ) assembly. During spermatogenesis, also regulates distal elongation of the basal-body and their docking (anchoring) to the plasma membrane and as a consequence, regulates the initiation and proper elongation of axonemal microtubules. Within the complex, required to recruit or stabilize Cby at the distal basal body of cilia to promote DZIP1-mediated early ciliary membrane formation and initiate TZ assembly. May also act with Dzip1 to restrict cep290 localization to the proximal part of the TZ. May also be involved in recruitment or stabilization of Mks1 at the TZ.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:31821146}. Note=Localizes at the transition zone (TZ) in type I sensory neurons and spermatocytes (PubMed:31821146). Localizes at the centriolar distal ends of early spermatocytes and in elongating spermatids, when the TZ migrates away from the basal body, localizes at the ring centriole (PubMed:31821146). {ECO:0000269|PubMed:31821146}.
Interaction partners:
- GH21622p
- Chibby, isoform E
- Cilium assembly protein DZIP1L
Sequence:
MFRRGKLSFLNTKDDRVKIINERINITERHLMEMCSSFALVTRKMAKYRDSFDELAKSVKSYADDEEINESLCQGLKSFTNAVTIMGDYMDINVHRLEHKIVNELAQFEQLCKSTRDNLRLAVIARDKEVLRQRQMLELKSKFSANNSAADSELFKAKMEVQRTNKEIDDIIGNFEQRKLRDLKQIISDFILIAMKQHTKALEILSASYYDIGTIDERDDFIEFQKLMKTKEELASRKTALKKGLRSQSMDSLEHEHLVSPLKRRPKLSRSNRNLTGAGINHGSKTEPEDETDEQDEEEDDEDEETEQSGEEDEESGTATDDEREPTQPGNQVPPRENVFGAKIRSASKDIATPSTSASATSAPSKPSRQTVKHPFKAVASTHVRLQKQFHVPQH
Protein: Oligosaccharyltransferase complex subunit (Q8TBU1)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU366060}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU366060}.
Interaction partners:
Sequence:
MIVYALMVVSYFLVTGGIIYDVIVEPPSIGSMTDEHGHQRPVAFLANRVNEQCIMEGLASSFLFTIGGLGFIFLDRWNAPNIPKLNRFLLLFIGFVCVLLSFFMARVFMRMKLPGYLMG
Protein: E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) (Q8IYW5)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:19500350, ECO:0000269|PubMed:21041483, ECO:0000269|PubMed:22742833}. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage. {ECO:0000255|HAMAP-Rule:MF_03066}.
Interaction partners:
- Ubiquitin-conjugating enzyme E2 N
- TP53-binding protein 1
- Mediator of DNA damage checkpoint protein 1
- E3 ubiquitin-protein ligase RNF8
- Polyubiquitin-C
- Vacuolar protein sorting-associated protein 29
- Histone H2A type 2-C
- Breast cancer type 1 susceptibility protein
- Histone H2AX
- Ubiquitin-ribosomal protein eS31 fusion protein
Sequence:
MALPKDAIPSLSECQCGICMEILVEPVTLPCNHTLCKPCFQSTVEKASLCCPFCRRRVSSWTRYHTRRNSLVNVELWTIIQKHYPRECKLRASGQESEEVADDYQPVRLLSKPGELRREYEEEISKVAAERRASEEEENKASEEYIQRLLAEEEEEEKRQAEKRRRAMEEQLKSDEELARKLSIDINNFCEGSISASPLNSRKSDPVTPKSEKKSKNKQRNTGDIQKYLTPKSQFGSASHSEAVQEVRKDSVSKDIDSSDRKSPTGQDTEIEDMPTLSPQISLGVGEQGADSSIESPMPWLCACGAEWYHEGNVKTRPSNHGKELCVLSHERPKTRVPYSKETAVMPCGRTESGCAPTSGVTQTNGNNTGETENEESCLLISKEISKRKNQESSFEAVKDPCFSAKRRKVSPESSPDQEETEINFTQKLIDLEHLLFERHKQEEQDRLLALQLQKEVDKEQMVPNRQKGSPDEYHLRATSSPPDKVLNGQRKNPKDGNFKRQTHTKHPTPERGSRDKNRQVSLKMQLKQSVNRRKMPNSTRDHCKVSKSAHSLQPSISQKSVFQMFQRCTK
Protein: Metaxin-2 homolog (Mitochondrial outer membrane import complex protein 2) (P34599)
Organism: Caenorhabditis elegans
Function: Involved in transport of proteins into the mitochondrion.
Subcellular location: Mitochondrion outer membrane {ECO:0000305}.
Interaction partners:
- SAM50-like protein gop-3
- Metaxin-1 homolog
- HAP1 N-terminal domain-containing protein
- Mitochondrial import receptor subunit TOM7 homolog
- MICOS complex subunit MIC19
- Putative ATP-dependent RNA helicase ZK686.2
- Mitochondrial import receptor subunit TOM20 homolog
- MICOS complex subunit MIC60-1
- DNA-directed RNA polymerase III subunit RPC8
- Mitochondrial import receptor subunit TOM40 homolog
Sequence:
MSSSGVITQLVTDALSMNAAQDWEDVSLFTPYLNDQALMYDFADCLAVQTFLRMTSLPFNVRQRPNVDFISPDGVVPLLKINKTLITGFNAIVDFVHKKGVTLTSHLSETQVADMRANISMIEHLLTTVEKFVLWNHDETYDKVTKLRYGSVYHWPLSSVLPFVKRRKILEELSDKDWDTKTMDEVGEQADKVFRALSAQLGSQKYLTGDLPTEADALLFGHMYTLITVR
Protein: Two-component response regulator ARR5 (Response reactor 2) (Q9SB04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Histidine kinase 4
- Histidine kinase 3
- Histidine kinase 2
- Histidine-containing phosphotransfer protein 3
- Histidine-containing phosphotransfer protein 5
- Two-component response regulator ARR22
- Adenylate isopentenyltransferase 7, mitochondrial
- Pseudo histidine-containing phosphotransfer protein 6
- Protein WUSCHEL
- Adenylate isopentenyltransferase 3, chloroplastic
Sequence:
MAEVLRPEMLDISNDTSSLASPKLLHVLAVDDSMVDRKFIERLLRVSSCKVTVVDSATRALQYLGLDGENNSSVGFEDLKINLIMTDYSMPGMTGYELLKKIKESSAFREIPVVIMSSENILPRIDRCLEEGAEDFLLKPVKLADVKRLRDSLMKAEERAFKNIMHKRELEANDIYSQLKRAKI
Protein: Plasmodium RESA N-terminal domain-containing protein (Q8IK23)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MNRINSFLLNLSNGIFDNNNNNVNNKDKNVYSFNSNKMNNKSNKFYSSFHFMCLVVYIISLFFITLTNIYENNTSLSIKHDKLFMRTLSEIEKENYTSIESNNEKSKLNDELNNSIIKNKVDLKTIDINDLSRQLTKDELYDVLNSLEEIPPKRVLINLWYQSLNIAKDMKELLKELKGYVDEYLNKNNPYDCDNFINDNNSIWIDCLNDIVETLSYEEMEYIEKFHNLLNQDITVNDIVNFIYKCINYFDELKKKLFDKYKEKFEEKIMNSQKSHEV
Protein: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) (Q93084)
Organism: Homo sapiens (Human)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}.
Interaction partners:
- Phospholamban
- Sarcolipin
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- Sarcoplasmic reticulum histidine-rich calcium-binding protein
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
- Histone acetyltransferase KAT5
- Nuclear receptor ROR-alpha
- Translocating chain-associated membrane protein 2
- Stromal interaction molecule 1
Sequence:
MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNHMHEEMSQK
Protein: 6-phospho-beta-glucosidase (EC 3.2.1.86) (Cellobiose-6-phosphate hydrolase) (Phospho-chitobiase) (P17411)
Organism: Escherichia coli (strain K12)
Function: Hydrolyzes a wide variety of P-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, gentiobiose-6P, methyl-beta-glucoside-6P and p-nitrophenyl-beta-D-glucopyranoside-6P. Is also able to hydrolyze phospho-N,N'-diacetylchitobiose.
Interaction partners:
- PTS system N,N'-diacetylchitobiose-specific EIIA component
- PTS system N,N'-diacetylchitobiose-specific EIIC component
- PTS system N,N'-diacetylchitobiose-specific EIIB component
- Chitooligosaccharide deacetylase ChbG
- 6-phospho-beta-glucosidase AscB
- HTH-type transcriptional regulator ChbR
- PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component
- 6-phospho-beta-glucosidase BglA
- 6-phospho-beta-glucosidase BglB
- Periplasmic beta-glucosidase
Sequence:
MSQKLKVVTIGGGSSYTPELLEGFIKRYHELPVSELWLVDVEGGKPKLDIIFDLCQRMIDNAGVPMKLYKTLDRREALKDADFVTTQLRVGQLPARELDERIPLSHGYLGQETNGAGGLFKGLRTIPVIFDIVKDVEELCPNAWVINFTNPAGMVTEAVYRHTGFKRFIGVCNIPIGMKMFIRDVLMLKDSDDLSIDLFGLNHMVFIKDVLINGKSRFAELLDGVASGQLKASSVKNIFDLPFSEGLIRSLNLLPCSYLLYYFKQKEMLAIEMGEYYKGGARAQVVQKVEKQLFELYKNPELKVKPKELEQRGGAYYSDAACEVINAIYNDKQAEHYVNIPHHGQIDNIPADWAVEMTCKLGRDGATPHPRITHFDDKVMGLIHTIKGFEIAASNAALSGEFNDVLLALNLSPLVHSDRDAELLAREMILAHEKWLPNFADCIAELKKAH
Protein: MAGUK p55 scaffold protein 4 (R4GN59)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MHVYSLAEAPAGRMIQSDKGADPPDKKDMKLSTATNPQNGLSQILRLVLQELSLFYGRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNIPESEEAMRIVCLV
Protein: Transcription initiation factor TFIID subunit 9 (TATA binding protein associated factor 21kDa subunit) (TBP-associated factor 9) (AtTAF9) (Q9SYH2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 6
- Transcription initiation factor TFIID subunit 4b
- Transcription initiation factor TFIID subunit 11
- Ubiquitin C-terminal hydrolase 22
- Transcription initiation factor TFIID subunit 6b
- Transcription initiation factor TFIID subunit 12
Sequence:
MAGEGEEDVPRDAKIVKSLLKSMGVEDYEPRVIHQFLELWYRYVVEVLTDAQVYSEHASKPNIDCDDVKLAIQSKVNFSFSQPPPREVLLELAASRNKIPLPKSIAGPGVPLPPEQDTLLSPNYQLVIPKKSVSTEPEETEDDEEMTDPGQSSQEQQQQQQQTSDLPSQTPQRVSFPLSRRPK
Protein: Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (ICIL-1RA) (IL1 inhibitor) (Anakinra) (P18510)
Organism: Homo sapiens (Human)
Function: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
Subcellular location: [Isoform 1]: Secreted {ECO:0000269|PubMed:32384874}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
Interaction partners:
- Interleukin-1 receptor type 1
- Interleukin-1 receptor type 2
- Interleukin-1 alpha
- Interleukin-1 beta
- Interleukin-8
- Interleukin-6
- Interleukin-10
- C-reactive protein
- Tumor necrosis factor
- Tumor necrosis factor receptor superfamily member 1B
Sequence:
MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
Protein: Homeobox protein abdominal-A (P29555)
Organism: Drosophila melanogaster (Fruit fly)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for segmental identity of the second through eighth abdominal segments. Once a pattern of abd-A expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments. Appears to repress expression of Ubx whenever they appear in the same cell, but abd-A is repressed by Abd-B only in the eight and ninth abdominal segments.
Subcellular location: Nucleus {ECO:0000305|PubMed:1979297}.
Interaction partners:
- Homeobox protein extradenticle
- Homeobox protein homothorax
- Homeotic protein antennapedia
- Segmentation protein fushi tarazu
- Homeotic protein deformed
- Homeotic protein Sex combs reduced
- Homeobox protein abdominal-B
- Homeotic protein ultrabithorax
- Protein teashirt
- Protein grainyhead
Sequence:
MSKFVFDSMLPKYPQFQPFISSHHLTTTPPNSSSAAVAAALAAAAASASASVSASSSSNNNSSNTIAGSNTSNTNNSSSSPSSSSNNNSNLNLSGGSLSPSHLSQHLGQSPHSPVSSSSPFQQHHPQVQQQHLNHQQQQHLHHQQQQHHHQYSSLSAALQLQQQQHHISKLAAAAVASHGHAHQQLLLTPPSAGNSQAGDSSCSPSPSASGSSSLHRSLNDNSPGSASASASASAASSVAAAAAAAAAAASSSFAIPTSKMYPYVSNHPSSHGGLSGMAGFTGLEDKSCSRYTDTVMNSYQSMSVPASASAQFAQFYQHATAAASAVSAASAGAIGVDSLGNACTQPASGVMPGAGGAGGAGIADLPRYPWMTLTDWMGSPFERVVCGDFNGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARRDREEQEKMKAQETMKSAQQNKQVQQQQQQQQQQQQQQQQQHQQQQQQPQDHHSIIAHNPGHLHHSVVGQNDLKLGLGMGVGVGVGGIGPGIGGGLGGNLGMMSALDKSNHDLLKAVSKVNS
Protein: Ring finger protein 34 (G3V504)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nuclear body {ECO:0000256|ARBA:ARBA00034306}.
Interaction partners:
Sequence:
MWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQ