wanglab/gogpt-training-data huggingface dataset:
Protein: NADPH oxidoreductase (EC 1.-.-.-) (Stearoyl-CoA 9-desaturase electron transfer partner) (P9WNE9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9-desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000305|PubMed:17087501}.
Interaction partners:
- NADPH-dependent stearoyl-CoA 9-desaturase
- Conserved protein
- Putative acyl-[acyl-carrier-protein] desaturase DesA1
- Putative acyl-[acyl-carrier-protein] desaturase DesA2
- Possible nitrogen fixation related protein
- Probable ferredoxin/ferredoxin--NADP reductase
- Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH
- IscS-like cysteine desulfurase
- Long-chain-fatty-acid--CoA ligase FadD13
- Probable multifunctional mycocerosic acid synthase membrane-associated Mas
Sequence:
MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI
Protein: Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Q9WUI9)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q15596}.
Interaction partners:
- Estrogen receptor
- Retinoic acid receptor RXR-alpha
- Nuclear receptor coactivator
- Glucocorticoid receptor
- Nuclear receptor coactivator 3
- Histone lysine acetyltransferase CREBBP
- Estrogen receptor beta
- Bile acid receptor
- Nuclear receptor subfamily 1 group I member 3
- Androgen receptor
Sequence:
MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMVNGGSWTGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDKQSCLICVARRVPMKERPALPSSESFTTRQDLQGKITFLDTSTMRDAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISIHMLHREQNVCVMNPDLTGQAMGKPLSPMSSSSPARQAMCSGNPGQDVALGSNMNFPMNGPREQMSMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGLNPGQPSSVLSPRHRMSPGVAGSPRVPPSQFSPAGSLHSPAGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGPSLASPDLKMGNSQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAQASCHPEEQKRPNDSSMPQAASEDRAEGHSRLHESKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELNQESSGTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVTPVGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRSSMPSGEWAPQSPAVRVTCAATTGAMNRPIQGGMIRNPTASIPMRANSQPGQRQMLQPQVMNIGPSELEMNMGGPQYNQQQAPPNQTAPWPESILPIDQASFGSQNRHPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQESSMMLEQKPPVFPQQYASQTQMAQGSYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQQNRQPLMNQISGVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPTGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQPASDINGWAQGSMGGNSMFSQQSPPHFGQQANTSMYNNNMNINVSMATNTAGLSNMNQMTGQMSMTSVTSVPTSGLSSMGPEQVNDPALRGSSLFTTNQLPGMDMIKQEGDGSRKYC
Protein: Varicose (A1XXK3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVRWSARSRRQARQDKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIFLKGLLGSSSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIG
Protein: 5'-3' exonuclease (EC 3.1.11.-) (P9WNU3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: 5'-3' exonuclease acting preferentially on double-stranded DNA.
Interaction partners:
- Protein RecA
- Putative lipoprotein LppK
- Beta sliding clamp
- Calcineurin-like phosphoesterase domain-containing protein
- ERCC4 domain-containing protein
- Multifunctional non-homologous end joining DNA repair protein LigD
- DNA ligase C
- DNA ligase B
- Probable helicase HelZ
- Uncharacterized protein Rv1278
Sequence:
MRSPLVLLDGASMWFRSFFGVPSSITAPDGRPVNAVRGFIDSMAVVITQQRPNRLAVCLDLDWRPQFRVDLIPSYKAHRVAEPEPNGQPDVEEVPDELTPQVDMIMELLDAFGIAMAGAPGFEADDVLGTLATRERRDPVIVVSGDRDLLQVVADDPVPVRVLYLGRGLAKATLFGPAEVAERYGLPAHRAGAAYAELALLRGDPSDGLPGVPGVGEKTAATLLARHGSLDQIMAAADDRKTTMAKGLRTKLLAASAYIKAADRVVRVATDAPVTLSTPTDRFPLVAADPERTAELATRFGVESSIARLQKALDTLPG
Protein: Chaperone protein DNAJ, putative (Q583X4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTTYGHRPEHMLHAWRTLGLRANPTYEEIRAAYRRLAFATHPDRSNEPGTKERFQKLQAAYEAAVENCRRMAALGGYRLSGDAANFDWRAEVARVREAWARKHGLGSDAAEEEEEETTARKKRQQTKTAAKGTKTAKPASASASAAPDFSGTNSPTPARGRKKASPRNSRRQQKRGSATTSRWSKPVANKKGKPKPPFTLFSSPRSPPPPASRGADGVAGENKSLNTSRAGSPGATTSHTSERRAQVVRRRRRCFLSNEDKMICRLMAVEAARRLALYVFEGATRRIISQMLAEVRIRCAIKQFEDLAWKKLVKYVQLGPSDALVRHKGKRRIVA
Protein: Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1) (Glutathione peroxidase ceruloplasmin) (EC 1.11.1.9) (Glutathione-dependent peroxiredoxin ceruloplasmin) (EC 1.11.1.27) (Q61147)
Organism: Mus musculus (Mouse)
Function: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:16906150}. Note=Colocalizes with GCP1 in secretory intracellular compartments. {ECO:0000250|UniProtKB:P13635}.
Interaction partners:
- Ferroportin
- Heme oxygenase 1
- Frataxin, mitochondrial
- Ferrochelatase, mitochondrial
- Heme oxygenase 2
- Hephaestin
- Copper-transporting ATPase 2
- Myeloperoxidase
- Pregnancy zone protein
- Albumin
Sequence:
MKFLLLSTFIFLYSSLALARDKHYFIGITEAVWDYASGTEEKKLISVDTEQSNFYLQNGPDRIGRKYKKALYFEYTDGTFSKTIDKPAWLGFLGPVIKAEVEDKVYVHLKNLASRIYTFHAHGVTYTKEYEGAVYPDNTTDFQRADDKVLPGQQYVYVLHANEPSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLYKEKEKNIDQEFVLMFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSMCAADRVKWYLFGMGNEVDVHSAFFHGQALTSRNYQTDIINLFPATLIDAYMVAQNPGVWMLSCQNLNHLKAGLQAFFQVRDCNKPSPEDNIQDRHVRHYYIAAEEVIWNYAPSGTDIFTGENLTALESDSRVFFEQGATRIGGSYKKMAYREYTDGSFTNRKQRGPDEEHLGILGPVIWAEVGDTIKVTFHNKGQHPLSIQPMGVSFTAENEGTYYGPPGRSSQQAASHVAPKETFTYEWTVPKEMGPTYADPVCLSKMYYSGVDPTKDIFTGLIGPMKICKKGSLLADGRQKDVDKEFYLFPTVFDENESLLLDDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRDTANLFPHKSLTLLMNPDTKGTFDVECLTTDHYTGGMKQKYTVNQCQRQFEDFTVYLGERTYYVAAVEVEWDYSPSRAWEKELHHLQEQNVSNVFLDKEEFFIGSKYKKVVYRQFTDSSFREQVKRRAEDEHLGILGPPIHANVGDKVKVVFKNMATRPYSIHAHGVKTESSTVVPTLPGEVRTYTWQIPERSGAGREDSACIPWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFSPKKKMEFFLLFLVFDENESWYLDDNIKTYSEHPEKVNKDNEEFLESNKMHAINGKMFGNLQGLTMHVKDEVNWYVMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDLFPGTYQTLEMFPQTPGTWLLHCHVTDHVHAGMATTYTVLPVEQETKSG
Protein: Protein arginine N-methyltransferase 6 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT6) (Q6NWG4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q96LA8}.
Interaction partners:
- Protein arginine N-methyltransferase 5
- Histone deacetylase 1
- Histone H3.2
- Histone H3.3
- Histone H3
- rRNA 2'-O-methyltransferase fibrillarin
Sequence:
MSQHATKKRKLDRSTEDYMYFDSYSDVTIHEEMIADTVRTNTYRMGIFKNSKSIEGKVVLDVGAGTGVLSLFCAQAGARKVYAVEASSIADQAVKIVKLNQMEDRIEVIKSTLETIELAEKVDVIVSEWMGYALLHESMLNSVIFARDKWLKPGGLILPSRADLYIAPINDVVVEGRLDFWSTVKGQYGVDMSCMTDFARKCIMNKDITVNPVTVEDVLSHPCKFAELDLNTVTLEQLRDVNGSFSCVCFGSSSIHAFCVWFTVTFPAEEKALVLSTSPFKAETHWKQAVLYLDDAVDVMQDTKVEGEISLYPSEENSRHICIRVDYVIGEQKKHSKSFSIPDQYLEVK
Protein: RE32772p (Q8SYV1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}.
Interaction partners:
Sequence:
MDQPLVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVDECKVQLPLTETIRPPEEIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQAQILSQDEYAQLMCNFVEIVRTHEDLLIQIEECNDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAVGADHRDRYFVLFPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNANNPSLPMGIKRQLSNLSNSSLGHLNAAHMSPPSSHILLPPGGRPPATPSSIPAGSSSGGSHSHQGSPATNSMSHHKRSQSFNHHLSYNQYTPTQPPPHHLHPPQPPSLPSHLGASGPRSSSAQTPNSKTAAPLQASSMDASPAIQAAAAAAAAAVGMGVPSARKGSTKANWTISCLRPTPPLRPSLLNATSGSGSGSGGSGGGGSSSSNALASYCSGRKNQPTYEEDALVLRVFEAYCAAYQNNARNTIHSGLENEDMTPTLRQLWTAIRQMQQDMSQIKLQINEERALRADLQQLLMQHLETSSVSSGANTPKC
Protein: Cytochrome P450 1A (EC 1.14.14.1) (Q5U396)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU368045}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368045}. Microsome membrane {ECO:0000256|RuleBase:RU368045}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368045}.
Interaction partners:
- tRNA-uridine aminocarboxypropyltransferase 1
- Aryl hydrocarbon receptor nuclear translocator 2
- Aryl hydrocarbon receptor 2.
- Aryl hydrocarbon receptor 1a.
Sequence:
MNLENISHTATSEVTLILCAFALLLLALHGRRRAPGVPVPPGPRPWPIVGNFLQMEEQVHLSLTNLRVQYGDVFQVKMGSLVVVVLSGYTTIKEALVRQGDAFAGRPDLYTFSAVANGTSMTFSEKYGEAWVLHKKICKNALRTFSQTEPKDSNASCLLEERICVEAIDMVETLKAQGEEFGDSGIDPVQLLVTSVANVVCTLCFGKRYSHNDKEFLTIVHINNEVLRLFAAGNLADFFPIFRYLPSPSLRKMVEFINRMNNFMERNIMEHLVNFDTNCIRDITDALIAMCEDRQEDKESAVLSNSQIVHSVIDIFGAGFDTIITGLQWSLLYLIKFPNIQDKIVQEIDNQVGMDRLPQFKDRPNMPYTEAFINEVFRHASYMPFTIPHCTTENITLNGYFIPKDTCVFINQYQVNHDIEIWDDPESFRPERFLTLSGHLNKSLTEKVMIFGMGIRRCLGDNIARLEMFVFLTTLLHRLHIENVPGQELDLSSTFGLTMKPRPYRIKIIPRN
Protein: Protamine-2 (Sperm histone P2) (Sperm protamine P2) [Cleaved into: Basic nuclear protein HPI1; Basic nuclear protein HPI2; Basic nuclear protein HPS1; Basic nuclear protein HPS2; Sperm histone HP4 (Sperm protamine P4); Sperm histone HP2 (Sperm protamine P2) (P2'); Sperm histone HP3 (P2'') (Sperm protamine P3)] (P04554)
Organism: Homo sapiens (Human)
Function: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P07978}. Chromosome {ECO:0000250|UniProtKB:P07978}.
Interaction partners:
- Sperm protamine P1
- Nuclear transition protein 2
- Spermatid nuclear transition protein 1
- Kelch-like protein 10
- Protamine-3
Sequence:
MVRYRVRSLSERSHEVYRQQLHGQEQGHHGQEEQGLSPEHVEVYERTHGQSHYRRRHCSRRRLHRIHRRQHRSCRRRKRRSCRHRRRHRRGCRTRKRTCRRH
Protein: Protein-L-isoaspartate O-methyltransferase 2 (AtPIMT2) (EC 2.1.1.77) (Q64J17)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Subcellular location: Nucleus.
Interaction partners:
- tRNA
- tRNA
- F18O14.31
Sequence:
MNTNTQTEQQIIREETRIDKIIKKRKKKMRAQVLLCPTITAYGRLYCAPRRLHRYNSSSSSSQFLNLNLSRFSGALFFHMEQFQSGTGSSGKRGMVENLKRYGVISSKRVAQVMEALDRGLFVPVGSSAYVDTPVPIGYNATISAPHMHATCLQLLEDKLHPGMRALDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKSVAASFLKKGSLSLHVGDGRKGWQEFAPYDAIHVGAAASEIPQPLLDQLKPGGRMVIPLGTYFQELKVIDKNEDGSIKVHTETSVRYVPLTSRVEQLGGF
Protein: MICOS complex subunit MIC60-2 (Inner mitochondrial membrane protein 2) (Mitofilin homolog 2) (Q9XXN2)
Organism: Caenorhabditis elegans
Function: Sustains mitochondrial morphology probably through maintaining cristae morphology. May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:20578245}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:20578245}. Note=Localized to cytoplasmic foci in embryos and gonads. Evenly distributed between the periphery and the cristae regions of the mitochondrion inner membrane. {ECO:0000269|PubMed:20578245}.
Interaction partners:
- MICOS complex subunit MIC19
- MICOS complex subunit MIC27
- MICOS complex subunit Mic10
- MICOS complex subunit MIC13
- MICOS complex subunit MIC60-1
- ABC transporter ATP-binding protein/permease wht-1
- SAM50-like protein gop-3
- ATP synthase subunit beta, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- ATP synthase subunit alpha, mitochondrial
Sequence:
MRGSRNLLTQRLASSRATGSSGGLKFVGATVGAVTAGAAGVAGYASYDNEFRKKLEGVIPGSRTILNYTIGEEEPPAPRLKDLRPLQYSADPKVPPKPFEPKPVKKELIGVKENLKETTEPKKIEKKPENPYIGAKTPLNPQERNEKLTESLKNHLTQAEKATKVATSAKLETIRAIEHHVQTIREAIEAGKDGDWDSVTVAHLKAKRLAEKDEKAEKLARNAVADLVTEANLGGQGETTQLNPLVPISKATAEKLSNELDEMISNVKHVDSERIFVHDYSDRVAESRRKFQMELKAVHPNLNYEDGMKIKKADLHTILAHAHLRIDQLSQKLIDSKLNEEKRIQSIIAKKKEDLLEKLRLETNAKQAAVIPEFDKKKLDAELARATAEIQKKYDEKLKEVVRTQKQLYDIEHAKDVDEAVLKERNLHSSAVGKALAQLAGIEKALSGHLQMDIENRKSKQMWLATQNLKGTVIFGNRASCCMEGRRAPLGDQMKTLLSCCGGGNSDEFVKTINTAMSKTSKVRGEYTEQDLNTRFNKVCRIGRRVAYVNEGGALAHLYSWLKSSLTIELVPKKGANESLTPAVENNFTLLTRAEQLWKSGKKSDAIRVLQLTDGATRRVAADFIADARRQHEALLLSRLLLAHAALTSIRSTY
Protein: p-GlycoProtein related (Q22656)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEENSNNFSTPLLPQSDEKKPSQICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQPFMSYTFGEVSQVLVTITNAINNKTIDPADLEKAYEEYERGMNQVVFHFFLCGCAYFIFASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALIIAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSIAFQTLGAYKTVCSLNGQKTEIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSGTLETAVVVRLFHYMLFGAFCLSEALPHISRLAGAISSTAPIAEMLIKDDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPLLYLAEYCYEAATETAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQGIQVETPSD
Protein: Orf17 (Q83Z60)
Organism: Streptomyces clavuligerus
Interaction partners:
Sequence:
MTTPLADYAKFAGKRIAIVEHMQNHPFVLGLHQAREHGLEVWLLTGDRSWYTHGHDWDSHPLAAAVDRVVDVDTTDLAAVLAAVTDESGQCLVDGLTSFSDYHTVIAAQAAQRLSLPGPDPEAVETANEKDRLRLALGDVPYNIPHARVSSREQLDEAVRKLGFPMIAKPPAEAISYGVRRVDTMAELVEAYEELSGVRHSLRGQPRSGDVLLETYVEGVEVSVETMTVDGYTHVFGVTSKDLFGDPAYIECGHTFPVPLSDEEREALYAAVRGTLEAIGYRHGPCHTEVRRTETGWRIIEANPRTPSSCMTMLVTDVTGRSPILDAWLLTIGEAPPIEPVVHNGGAAVRMIYPTRKGTLTRVDGIEAAAAVPGVQVLLHVEKGDKLLQRMDNSSCVGFTYCAGADREEAQALADRAAGYLDFVVEEDERGERGGES
Protein: HORMA domain-containing protein 1 (Cancer/testis antigen 46) (CT46) (Newborn ovary HORMA protein) (Q86X24)
Organism: Homo sapiens (Human)
Function: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9D5T7}. Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). {ECO:0000250|UniProtKB:Q9D5T7}.
Interaction partners:
- Synaptonemal complex protein 3
- Interactor of HORMAD1 protein 1
- MutS protein homolog 4
- Meiotic recombination protein SPO11
- Synaptonemal complex protein 1
- Meiotic recombination protein REC8 homolog
- Synaptonemal complex central element protein 1
- Synaptonemal complex central element protein 2
- Mitotic spindle assembly checkpoint protein MAD2B
- Pachytene checkpoint protein 2 homolog
Sequence:
MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTNNGPLMDFISKNQSNESSMLSTDTKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMENIDSTILSPKQIKTPFQKILRDKDVEDEQEHYTSDDLDIETKMEEQEKNPASSELEEPSLVCEEDEIMRSKESPDLSISHSQVEQLVNKTSELDMSESKTRSGKVFQNKMANGNQPVKSSKENRKRSQHESGRIVLHHFDSSSQESVPKRRKFSEPKEHI
Protein: Pyrin and HIN domain family member 1 (X6RHR0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKFPGDAGLGKLIEFFKEIPTLGDLAETLKREKLKVANKIESIPVKGIIPSKKTKQKEVYPATPACTPSNRLTAKGAEETLGPQKRKKPSEEETGTK
Protein: Ral guanine nucleotide dissociation stimulator-like 1 (G4SFM6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MATRYWGDEKHPDAIYAVYLRKVRYVPPQGYEGVPRYRAIDPDRPKTESSEMSGADHLEWESVKEKLIKAGTVERLVECLVGSDDMMDSRHFNVFFATYRSFTDSAIVLDCLLRRYETLENEVNGSTSALLVQNSIRQIVMCWLETYPEDFYDSDKDFAMLSSLLDFGGRNKLTELRAKARKQREVFKRIYDEGGMQAALPSLGQYVADMGFDPSDYPNNIKERVKMFDVGKENCVQIAEQLTFWDAALFKELLIHQCQGCVWSKRRTAGERVYTVKATIEQFNSVSQRVMTSIVLPDCRPEYRAKIISKWIDIARELRALKNFSSLKAVLSSLQSEPVHRLKSAWNSVPNRSISQFRELSSIYETDEDGDQGNARKILEQEGTAKSSPLRRPQLIQNCRRTKSDVNLAECQGTVPYLGNFLTDLAMVDESTPDYTPENLINFEKRRKEFEVLAKLRLFQSAARAYNIPMDRMFCAWFFFLPCLDENECFNRSLEIEKPPMHSTPDLSSSRINSSMLSNGSQSTPVKNSTLSRLFNSSRTSEDSGSHNGNGTWHQHSHSYSSSTNSQIPSINTGSSLNISDGGVPQHSRDSGLQCEDWIDGRLDGGPPGPVPLSGTSTLPRGSNTNTPSSANASWTGGSEFTPSSLFPYSHSRSKSGESSLQEVKTSMSTRASADGTSGTQSLSRSATPIRTRLAEVFDSKVFSHQKKGSDASSCSSSSSLSANGNSQAQNSFYLARVGLDDDLQNTDGANYKCIKIENGDRMPQLVARALEKHLIEDDKNTYLLVQLLPRGGEFVLPDNCNPFYAMAPDPTSPMLNLLLRKRDGNGTIEGGASPQLGPSAKKLNRMKRTNLLRWSSGYL
Protein: Non-SMC condensin II complex subunit G2 (H0Y6U5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XLEESGEIKDMLLECFININYIKKEEGRRFLSCLFNWNINFIKMIHGTIKNQLQGLQKSLMVYIAEIYFRAWKKASGKILEAIENDCIQDFMFHGIHLPRRSPVHSKVREVLSYFHHQKKVRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRDPNLHAIEMDSEIQKQFEELYSLLEDPYPMVRSTGILGVCKITSKYWEMMPPTILIDLLKKVTGELAFDTSSADVRCSVFKCLPMILDNKLSHPLLEQLLPALRYSLHDNSEKVRVAFVDMLLKIKAVRAAKFWKICPMEHILVRLETDSRPVSRRLVSLIFNSFLPVNQPEEVWCERCVTLVQMNHAAARRFYQYAHEHTACTNIAKLIHVIRHCLNACIQRAVREPPEDEEEEDGREKENVTVLDKTLSVNDVACMAGLLEIIVILWKSIDRSMENNKEAKLYTINKFASVLPEYLKVFKDDRCKIPLFMLMSFMPASAVPPFSCGVISTLRSREEGAVDKSYCTLLDCLCSWGQVGHILELVDNWLPTEHAQAKSNTASKGRVQIHDTRPVKPELALVYIEYLLTHPKNRECLLSAPRKKLNHLLKALETSKADLESLLQTPGGKPRGFSEAAAPRAFGLHCRLSIHLQHKFCSEGKVYLSMLEDTGFWLESKILSFIQDQEEDYLKLHRVIYQQIIQTYLTVCKDVVMVGLGDHQFQMQLLQRSLGIMQTVKGFFYVSLLLDILKEITGSSLIQKTDSDEEVAMLLDTVQKVFQKMLECIARSFRKQPEEGLRVSDVEELTPPEHLSDLPPFSRCLIGIIIKSSNVVRSFLDELKACVASNDIEGIVCLTAAVHIILVINAGKHKSSKVREVAATVHRKLKTFMEITLEEDSIERFLYESSSRTLGELLNS
Protein: RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8) (Q59EK9)
Organism: Homo sapiens (Human)
Function: May act as an effector of RAP2A in neuronal cells.
Interaction partners:
- Mitochondrial glutathione transporter SLC25A39
- Ras-related protein Rap-2a
- AP-4 complex accessory subunit RUSC1
- AP2-associated protein kinase 1
- Ras-related protein Rap-2b
- AP-2 complex subunit sigma
- Adaptin ear-binding coat-associated protein 2
- AP-2 complex subunit beta
- Intersectin-1
Sequence:
MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS
Protein: LD15586p (Lethal (2) k09913, isoform A) (Lethal (2) k09913, isoform B) (Lethal (2) k09913, isoform C) (Lethal (2) k09913, isoform E) (Q7K274)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAAHFFRTAFYATAARKSMSLPFAGRTAATLAVGLSFGAQNSRAAVPYENAYADSFFGGCQTQGLLQRIPQTGYIQPPLMRNFSSLQTGHQQQQQPAPNSAMAPSNNRRYLSSQDITKNMTLYTSTKTQVEVDPKTLAFKKPTGNPLVLMMAWLMAKQKHLKKYAQIYTEMGFDVVVVHITPWQLLWPVKGSQVVAAETIRFLENNKSYEPIVMHGFSVGAYQLGEIMLQMSRDMDRYGSILDRFVCQVWDSAADITEIPVGVPKSIFPRNERMQSALRNYTLYHLKTFHNQATIHYMRSSQMFHSTLLKAPALFFVSDNDPIGPPSSNQSVREDWERANIKVTFKCWERSQHAAHYIRHREEYLQTLFQHLETCGVLEAIGVPKRAKL