wanglab/gogpt-training-data huggingface dataset:
Protein: EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) (Q5PPK9)
Organism: Rattus norvegicus (Rat)
Function: Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (By similarity). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (By similarity). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (By similarity). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles. Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q53HC9}.
Interaction partners:
- Vacuolar protein sorting-associated protein 51 homolog
- Vacuolar protein sorting-associated protein 53 homolog
- Vacuolar protein sorting-associated protein 54
- Syndetin
- Vacuolar protein sorting-associated protein 52 homolog
- Ccdc186
- RUN domain-containing protein 1
- Ribosome biogenesis protein BRX1 homolog
Sequence:
MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHQAGEIWHISASPADKGVLATCYNKTSDSRVQACAAVWRMPKELESGSHESPEDPASTAQTLELLCHLDNGAQGNVACVVWEPMGDGKKVISLADSHILLWDLQPSSSQAVLASSAALEGRGQLKFTSGRWSPHHNCTQVATASDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWSVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDVSDPEEHHTEKSKEPLQDNVIATYEEHEDSVYAVDWASADPWLFASLSYDGRLVINRVPRALKYHILL
Protein: Heterogeneous nuclear ribonucleoprotein A/B (D6R9P3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSEAGEEQPMETTGATENGHEAVPEGESPAGAGTGAAAGAGGATAAPPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGQGSTNYGKSQRRGGHQNNYKPY
Protein: CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] (O35732)
Organism: Mus musculus (Mouse)
Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity).
Interaction partners:
- FAS-associated death domain protein
- Caspase-8
- Receptor-interacting serine/threonine-protein kinase 1
- Ubiquitin-like-conjugating enzyme ATG3
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- E3 ubiquitin-protein ligase Itchy
- Tumor necrosis factor receptor superfamily member 6
- Receptor-interacting serine/threonine-protein kinase 3
- Tumor necrosis factor receptor superfamily member 10B
- TNF receptor-associated factor 2
Sequence:
MAQSPVSAEVIHQVEECLDEDEKEMMLFLCRDVTENLAAPNVRDLLDSLSERGQLSFATLAELLYRVRRFDLLKRILKTDKATVEDHLRRNPHLVSDYRVLLMEIGESLDQNDVSSLVFLTRDYTGRGKIAKDKSFLDLVIELEKLNLIASDQLNLLEKCLKNIHRIDLNTKIQKYTQSSQGARSNMNTLQASLPKLSIKYNSRLQNGRSKEPRFVEYRDSQRTLVKTSIQESGAFLPPHIREETYRMQSKPLGICLIIDCIGNDTKYLQETFTSLGYHIQLFLFPKSHDITQIVRRYASMAQHQDYDSFACVLVSLGGSQSMMGRDQVHSGFSLDHVKNMFTGDTCPSLRGKPKLFFIQNYESLGSQLEDSSLEVDGPSIKNVDSKPLQPRHCTTHPEADIFWSLCTADVSHLEKPSSSSSVYLQKLSQQLKQGRRRPLVDLHVELMDKVYAWNSGVSSKEKYSLSLQHTLRKKLILAPT
Protein: CD44 molecule (IN blood group) (H0YEV3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
XDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTNMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRND
Protein: bZIP transcription factor 18 (AtbZIP18) (bZIP protein 18) (O22873)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that may participate with bZIP34 in the gametophytic control of pollen development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. Nucleus, nucleoplasm {ECO:0000269|PubMed:27896439}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27896439}. Cytoplasm {ECO:0000269|PubMed:27896439}.
Interaction partners:
- Nuclear envelope-associated protein 1
- Putative nuclear envelope-associated protein 4
- Protein CROWDED NUCLEI 1
- Protein CROWDED NUCLEI 4
- Nuclear envelope-associated protein 3
- Basic leucine zipper 8
- Protein KAKU4
- SUN domain-containing protein 5
- SUN domain-containing protein 2
- SUN domain-containing protein 4
Sequence:
MEDPSNPQPNQSNLSQCPPLATAPTPAPVRGPYHRRAHSEVQFRLPEDLDLSEPFGGFDELGSEDDLFCSYMDIEKLGSGSGSASDSAGPSAPRSDNPFSAENGGAEAGNSRPRHRHSLSVDGSSTLESIEAKKAMAPDKLAELWVVDPKRAKRIIANRQSAARSKERKARYILELERKVQTLQTEATTLSAQLSLFQRDTTGLSSENTELKLRLQVMEQQAKLRDALNEQLKKEVERLKFATGEVSPADAYNLGMAHMQYQQQPQQSFFQHHHQQQTDAQNLQQMTHQFHLFQPNNNQNQSSRTNPPTAHQLMHHATSNAPAQSHSYSEAMHEDHLGRLQGLDISSCGRGSNFGRSDTVSESSSTM
Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (C3U1W5)
Organism: Gallus gallus (Chicken)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Interaction partners:
Sequence:
MFRSKRSGLVRRLWRSRVIPERDGGDGNGQSSERNATAVTAEGQRMAQPRRAHEGEGRPVRCCLFAERPGPELPPPPPPPPPGGASPPGPGGGEARSRLVLLERELKAVTYALLKRLKERSLHSLLQAVESRGGTPGGCVLVARGELRLGGGQAAPPHMLLGKLFRWPDMQHPAELKAMCECQRLGAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPNDEQKPLDLSDSTLSYTETEATNSPNVTPGEFSDASTSPDAVKRSHWCNVAYWEHRTRVGRLYTVYEQSVSIFYDLPQGNGFCLGQLNLENRSETVRRTRSKIGYGILLSKEPDGVWAYNRSEHPIFVNSPTLDIPNCRTLIVRKVMPGYSIKVFDYEKSCLLQHTAELDYADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLSNNR
Protein: Opsin Rh1 (Neither inactivation nor afterpotential E protein) (Outer R1-R6 photoreceptor cells opsin) (P06002)
Organism: Drosophila melanogaster (Fruit fly)
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular location: Cell projection, rhabdomere membrane {ECO:0000269|PubMed:23226104}; Multi-pass membrane protein {ECO:0000305}. Note=Upon white light stimulation, is internalized into the rhabdomere membranes. {ECO:0000269|PubMed:23226104}.
Interaction partners:
- Phosrestin-1
- Inactivation-no-after-potential D protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Neither inactivation nor afterpotential protein C
- Serine/threonine-protein phosphatase rdgC
- Guanine nucleotide-binding protein subunit beta-2
- Transient-receptor-potential-like protein
- Phosrestin-2
- Protein kinase C, eye isozyme
- Transient receptor potential protein
Sequence:
MESFAVAAAQLGPHFAPLSNGSVVDKVTPDMAHLISPYWNQFPAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMMGINLYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWSRYVPEGNLTSCGIDYLERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMNVKSLRSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLFKFEGLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVFGKVDDGKSSDAQSQATASEAESKA
Protein: Circadian clock oscillator protein KaiC (EC 2.7.11.1) (EC 3.6.4.-) (Q6L8J9)
Organism: Thermostichus vulcanus (Synechococcus vulcanus)
Function: Central component of the KaiABC oscillator complex, which constitutes the main circadian regulator in cyanobacteria. Complex composition changes during the circadian cycle to control KaiC phosphorylation. KaiA stimulates KaiC autophosphorylation, while KaiB sequesters KaiA, leading to KaiC autodephosphorylation. Clock output pathways impact the RpaA transcriptional regulator. KaiC enhances the autophosphorylation activity of SasA, which then transfers its phosphate group to RpaA to activate it. KaiB and KaiC together enhance the phospho-RpaA dephosphatase activity of CikA.
Interaction partners:
Sequence:
MTNLPEHQSSPTEQSSAEVKKIPTMIEGFDDISHGGLPQGRTTLVSGTSGTGKTLFAVQFLYNGITIFNEPGIFVTFEESPQDIIKNALSFGWNLQSLIDQGKLFILDASPDPDGQEVAGDFDLSALIERIQYAIRKYKATRVSIDSVTAVFQQYDAASVVRREIFRLAFRLKQLGVTTIMTTERVDEYGPVARFGVEEFVSDNVVILRNVLEGERRRRTVEILKLRGTTHMKGEYPFTINNGINIFPLGAMRLTQRSSNVRVSSGVKTLDEMCGGGFFKDSIILATGATGTGKTLLVSKFLETGCQQGERALLFAYEESRAQLSRNASSWGIDFEELERRGLLRIICAYPESAGLEDHLQIIKSEIADFKPSRVAIDSLSALARGVSNNAFRQFVIGVTGFAKQEEITGFFTNTTDQFMGSNSITESHISTITDTILLLQYVEIRGEMSRAINVFKMRGSWHDKGIREYVITEKGAEIRDSFRNFEGIISGTPTRISVDEKTELARIAKGMQDLESE
Protein: Protein dispatched homolog 1 (Q96F81)
Organism: Homo sapiens (Human)
Function: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Sonic hedgehog protein
- Zinc finger protein ZIC 2
- Homeobox protein SIX3
- Desert hedgehog protein
- Indian hedgehog protein
- Hepatocyte nuclear factor 3-beta
Sequence:
MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNGTVKSSFLPLDNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPHSEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKSYAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPRGPKSELEHEFYELEPLASHSCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSALLQPPLEQHTVCHFFSLNQRCSCPDAYKHLNYGPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLKATHQAVEGFVHPITHIHHCPCLQGRVKPAGMQNSLPRNFFLHPVQHIQAQEKIGKTNVHSLQRSIEEHLPKMAEPSSFVCRSTGSLLKTCCDPENKQRELCKNRDVSNLESSGGTENKAGGKVELSLSQTDASVNSEHFNQNEPKVLFNHLMGEAGCRSCPNNSQSCGRIVRVKCNSVDCQMPNMEANVPAVLTHSELSGESLLIKTL
Protein: Uncharacterized protein (Q38BG0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSFFGKFMKKFRRETPAPNMSEADCSELEEMIKRNPVAATLKDEWALFVHHIIGSPAETRKEIWVEKCKVPQTHSEIDRVGNLFMKFFKDDLIRRKWRGQFSYAVVGRENEGHLEVEVLLHSLKRKETTREVLWNLKLRYHTNAISSEVTDTHKCPNLHNIPL
Protein: Junctional sarcoplasmic reticulum protein (Q28264)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037847}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037847}. Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MAEETKHGGHKNGRKGGLSGSSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGVYDADGDGDFDVDDAKVLLEGPGGVAKRKTKAKVKELTKEELKKEKEKTESRKENKNEERRKGKKEKEDERKDKKIADADISRKESPKGKKDREKENVGLDKSAKAKESRKKSTNVKDASSKTASRDKDDTKEGKTSSKHTHSAKGNNQKRKN
Protein: Spindle and kinetochore-associated protein 3 (Q8IX90)
Organism: Homo sapiens (Human)
Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Subcellular location: Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:20813266}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. {ECO:0000269|PubMed:19360002}.
Interaction partners:
- SKA complex subunit 1
- Spindle and kinetochore-associated protein 2
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Centromere protein F
- Protein Spindly
- Kinetochore protein NDC80 homolog
- Serine/threonine-protein kinase PLK1
- Biorientation of chromosomes in cell division protein 1
- G2/mitotic-specific cyclin-B1
- Kinetochore protein Nuf2
Sequence:
MDPIRSFCGKLRSLASTLDCETARLQRALDGEESDFEDYPMRILYDLHSEVQTLKDDVNILLDKARLENQEGIDFIKATKVLMEKNSMDIMKIREYFQKYGYSPRVKKNSVHEQEAINSDPELSNCENFQKTDVKDDLSDPPVASSCISEKSPRSPQLSDFGLERYIVSQVLPNPPQAVNNYKEEPVIVTPPTKQSLVKVLKTPKCALKMDDFECVTPKLEHFGISEYTMCLNEDYTMGLKNARNNKSEEAIDTESRLNDNVFATPSPIIQQLEKSDAEYTNSPLVPTFCTPGLKIPSTKNSIALVSTNYPLSKTNSSSNDLEVEDRTSLVLNSDTCFENLTDPSSPTISSYENLLRTPTPPEVTKIPEDILQLLSKYNSNLATPIAIKAVPPSKRFLKHGQNIRDVSNKEN
Protein: Frataxin homolog, mitochondrial (EC 1.16.3.1) [Cleaved into: Frataxin homolog intermediate form] (Q07540)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:9180083, ECO:0000269|PubMed:9988680}.
Interaction partners:
- Cysteine desulfurase, mitochondrial
- Iron sulfur cluster assembly protein 1, mitochondrial
- Protein ISD11
- Iron sulfur cluster assembly protein 2, mitochondrial
- Ferrochelatase, mitochondrial
- Adrenodoxin homolog, mitochondrial
- NifU-like protein
- Iron-sulfur cluster biogenesis chaperone, mitochondrial
- J-type co-chaperone JAC1, mitochondrial
- Mitochondrial RNA-splicing protein MRS3
Sequence:
MIKRSLASLVRVSSVMGRRYMIAAAGGERARFCPAVTNKKNHTVNTFQKRFVESSTDGQVVPQEVLNLPLEKYHEEADDYLDHLLDSLEELSEAHPDCIPDVELSHGVMTLEIPAFGTYVINKQPPNKQIWLASPLSGPNRFDLLNGEWVSLRNGTKLTDILTEEVEKAISKSQ
Protein: Serine/threonine-protein kinase SAPK4 (EC 2.7.11.1) (Osmotic stress/abscisic acid-activated protein kinase 4) (RK2 kinase) (stress-activated protein kinase 4) (OsSAPK4) (Q5N942)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May play a role in signal transduction of hyperosmotic response.
Interaction partners:
- Probable protein phosphatase 2C 6
- protein-serine/threonine phosphatase
- Probable protein phosphatase 2C 8
- Probable protein phosphatase 2C 30
- bZIP transcription factor 23
- bZIP transcription factor ABI5 homolog
- bZIP transcription factor 46
- Os09g0456200 protein
- bZIP transcription factor TRAB1
- Os08g0379300 protein
Sequence:
MEKYEAVRDIGSGNFGVARLMRNRETRELVAVKCIERGHRIDENVYREIINHRSLRHPNIIRFKEVILTPTHLMIVMEFAAGGELFDRICDRGRFSEDEARYFFQQLICGVSYCHHMQICHRDLKLENVLLDGSPAPRLKICDFGYSKSSVLHSRPKSAVGTPAYIAPEVLSRREYDGKLADVWSCGVTLYVMLVGAYPFEDQDDPKNIRKTIQRIMSVQYKIPDYVHISAECKQLIARIFVNNPLRRITMKEIKSHPWFLKNLPRELTETAQAMYYRRDNSVPSFSDQTSEEIMKIVQEARTMPKSSRTGYWSDAGSDEEEKEEEERPEENEEEEEDEYDKRVKEVHASGELRMSSLRI
Protein: Conserved protein (O50398)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Conserved protein
- F420H
- Conserved protein
- Conserved protein
- Probable cold shock protein A
- 2-heptyl-1-hydroxyquinolin-4
- Probable nonspecific lipid-transfer protein
- CRISPR system endoribonuclease Csm6
- Conserved protein
- Universal stress protein Rv1636
Sequence:
MWAGYRWAMSVELTQEVSARLTSDLYGWLTTVARSGQPVPRLVWFYFDGTDLTVYSMPQAAKVAHITAHPQVSLNLDSDGNGAGIIVVGGTAAVVATDVDCRDDAPYWAKYREDAAKFGLTEAIAAYSTRLKITPTRVWTTPTG
Protein: Schlafen 3 (Schlafen3) (Slfn3 protein) (Q9Z0I5)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MKDIQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDGMGLDLVNSLPGIMHLPHDYLDFMQHKDYFFVFVKPLKPNQKGPGITTLKTNLYRRINSISDEVKVANAVQLLKSRTDPEEKAESRPSSPGKIVCNETLNECLSLFNRDWLAYEETFCFTKSIHAEVKLTPKEKIFPKEKILELLPQTVSAFANTDGGFLFIGLDGKTQQIIGFEAEKSNLVLLESEIEKCIQQLPVTHFCGEKEKIKYTCKFIEVRKSGAVCAYVCALRVERFCCAVFAAEPESWHVEGGCVKRFTTEEWVKRQMDATAVMPGKVICCPEALYMKPFSQHEGYEHLVRTELGSLLKGTLVISKSWALDLGLQEKQEVIWDVLHISQGSLLTLYVFVQGDENLEGNSSLLGELGAELKGYYKQIALTLKQMLLNHCGYTAEIGIIVKITYLGHKTMCLYDTSTKIRYPQKYYLSAKAVKDLEKALVEILGSYESFYSLPRRNWDSFMSAFLNVGSYIVPVLRNV
Protein: Filamin binding LIM protein 1 (E7EN81)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MASKPEKRVASSVFITLAPPRRDVAVAEEVRQAVCEARRGRPWEAPAPMKTPEAGLAGRPSPWTTPGRAAATVPAAPMQLFNGGCPPPPPVLDGEDVLPDLDLLPPPPPPPPVLLPSEEEAPAPMGASLIADLEQLHLSPPPPP
Protein: FERM domain-containing protein (H2KYX3)
Organism: Caenorhabditis elegans
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}. Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell projection, rhabdomere {ECO:0000256|ARBA:ARBA00043944}.
Interaction partners:
- FERM domain-containing protein
- RING-type E3 ubiquitin transferase
- Serine/threonine-protein kinase WARTS homolog
- Protein kinase domain-containing protein
- Serine/threonine-protein kinase pak-1
- Cell division control protein 42 homolog
- Na
- FERM domain-containing protein 8
Sequence:
MGGFSIFSRNTKPIYAKVSTMDADLEKIVIEKTWTGRHLFEAVCRIIGLRETWYFGLQFTNKKNIPCWLQNDKTICGQDIQKDTSDGTFNFLFLVKFYPEDVEPEIILDATRHLFFLQIREAILSMNLYCSPEASVLLASFAVQAMHGDCTEEVGPIDLDKHLPKSVIDQYDMSADMWRDRIKRWWSRNAGQSREEAELEYLRVAQDLEMYGILYYPICNNKETDLHLGISAQGLGIYKGVNRITPRPFFSWSEIKNIQFKNRKFHMKTVDKSTISFRSRETSIDSSILDLCIGTHNLYLRRRQPDTLEVQQMRSQAKEDKQRRAAEQAKVALERKERQQMEKEYKEMKQKVEVMTLELMKAQENIRKAEEANDQLAEKARHSEHETLMLYKQKSEVEAECNRLSMNNMKSEEALLRMERKAREAEILAKQMSMSLADVSLDANRKMTQYSSQSALIIDPNWHQQVSGHQSGHPGMPSTGSFHQLQSLDTHTHPQQMMSRSLNMPSSAFSSPIPSNQPLSHQQPQQMSQNTQAHQQQTQVQNQNQPPYYGGSGMIIPPPDPSISQIFEQQTTLMELEKSRSEYETRARIFKEHLEELRGDIDGLKRDGNVQNGQHREHDAVHAQNVAHGFDKFTTMRMKKSKSASSIGSSGSSDSLELNTVARHVAGRGIPRVSTVSTTSSSSILSHVMMLHRQQSYDLGNTEWQEADI
Protein: Gamma-aminobutyric acid receptor alpha-like (GABA(A) receptor alpha-like and glycine receptor-like subunit of Drosophila) (GRD) (Q24352)
Organism: Drosophila melanogaster (Fruit fly)
Function: GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. May combine with the ligand-gated ion channel subunit Lcch3 to form cation-selective GABA-gated ion channels.
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Gamma-aminobutyric acid receptor subunit beta-like
- Molybdenum cofactor synthesis protein cinnamon
- IP12579p
- Transporter
- Gamma-aminobutyric acid receptor subunit beta
- Rho guanine nucleotide exchange factor 3, isoform L
- IP03705p
Sequence:
MCTMPATRDASGSGDASTDLIAARSLSSHQGQRSNLRIFKLLISCCLLMLCIYPNAWPWSIGPGSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSWLTQSNNHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYLSRSSRILANTPDAST
Protein: Interferon gamma induced GTPase (Q811M6)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDLVTKLPQNIWKTFTLFINMANYLKRLISPWSKSMTAGESLYSSQNSSSPEVIEDIGKAVTEGNLQKVIGIVKDEIQSKSRYRVKIAVTGDSGNGMSSFINALRFIGHEEEDSAPTGVVRTTKKPACYSSDSHFPYVELWDLPGLGATAQSVESYLEEMQISTYHLIIIVASEQFSSNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRENLQQAQVRDPPLFLISCFSPSFHDFPELRNTLQKDIFSIRYRDPLEIISQVCDKCISNKAFSLKEDQMLMKDLEAAVSSEDDTANLERGLQTYQKVFGVDDGSLQQVARSTGRLEMGSRALQFQDLIKMDRRLELMMCFAVNKFLRVLESSWWYGLWNVVTRYFRHQRHKLVIEIVAENTKTSLRKALKDSVLPPEIH
Protein: CLAVATA3/ESR (CLE)-related protein 8 [Cleaved into: CLE8p] (Q2V4E2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Positively regulates the expression of the transcription factor WOX8 and thus, regulates early embryo development. Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2.
Subcellular location: [CLE8p]: Secreted, extracellular space {ECO:0000250|UniProtKB:O49519}.
Interaction partners:
- CLAVATA3/ESR
- CLAVATA3/ESR
- WUSCHEL-related homeobox 8
- Protein CLAVATA 3
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
- CLAVATA3/ESR
Sequence:
MKVLKRDSMLLLITLYFLLTTSMARQDPFLVGVEKDVVPAGTDLKQNKAKPHLPNLFRTMRRVPTGPNPLHHISPPQPGSLNYARN
Protein: N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) (Phosphatidylinositol-glycan biosynthesis class L protein) (PIG-L) (Q9Y2B2)
Organism: Homo sapiens (Human)
Function: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10085243, ECO:0000269|PubMed:14742432}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742432}.
Interaction partners:
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
- Glucosaminyl-phosphatidylinositol-acyltransferase PIGW
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Phosphatidylinositol-glycan-specific phospholipase D
- GPI alpha-1,4-mannosyltransferase I, catalytic subunit
Sequence:
MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKKELLQSCDVLGIPLSSVMIIDNRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGCSVLTLQSVNVLRKYISLLDLPLSLLHTQDVLFVLNSKEVAQAKKAMSCHRSQLLWFRRLYIIFSRYMRINSLSFL