wanglab/gogpt-training-data huggingface dataset:
Protein: Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I] (P09809)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Subcellular location: Secreted.
Interaction partners:
- Apolipoprotein B
- P-type phospholipid transporter
- Apolipoprotein A-II
- Phosphatidylcholine-sterol acyltransferase
- Apolipoprotein C-III
- Serum paraoxonase/arylesterase 1
- Apolipoprotein C-II
- Clusterin
- Apolipoprotein C-I
- Albumin
Sequence:
MKAVVLTLAVLFLTGSQARHFWQRDEPRSSWDKIKDFATVYVDTVKDSGREYVAQFEASAFGKQLNLKLLDNWDSLSSTVSKLQEQLGPVTQEFWDNLEKETEGLREEMNKDLQEVRQKVQPYLDEFQKKWQEEVERYRQKVEPLGAELRESARQKLTELQEKLSPLAEELRDSARTHVDTLRTKLAPYSNELQQRLAARLESIKEGGGASLAEYQAKAREHLSVLSEKARPALEDLRQGLLPVLESFKASVQNVLDEATKKLNTQ
Protein: RNA editing complex protein MP61 (Q38B60)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RNA-editing ligase 2, mitochondrial
- RNA-editing-associated protein 1
- RNA editing complex protein MP67
- RNA editing 3' exouridylylase MP99
- REH2-associated factor 1
- MP18 RNA editing complex protein
- RNA editing complex protein MP46
- RNA editing complex protein MP63
- RNA editing complex protein
- RNA editing associated helicase 2
Sequence:
MERGGRCLFRRWSTRALPSVSHTLRCRGTISNSGGEGNDAIAEPRRVRLVPSAPHGNNSSELFSVGVDPRSHTCDPDDPYSHIQIYRKDMVADAGGRAFQLSVDVPLKKFVDLFSDFDGKRCKLCNESYMQWHSHSSVIPHSGREALMLEMVRAYCGLPEDIAKMWWHRLNTSPAFNRIPKLSHDNSHTRKRRLQYLLKFLKDRDVIRDTFNVHNSSGTAGRSWEFERLEWIGDNVVKYVFNDRFNVIFPVREGGIRGRLGYAQFMIDGNDGLARAYDYLELQKLTLSDRVVSKFKSDVVETLFGELQLYIWSSETDAGTTCYPLPFTGEMFSLRALVWHVMEELAHVMFMYHVEHALAAIQRVVRENQLQFIRADPALRGHADLQSELANTVYAKKAASGPSKLTSTKVSPGARFRDGGASFYHEASNYDGFKRVCTLGGLLPRPFSPRELTSTTSFLPHLQEDSAMTRRVPVDWTRKLFDDCTGNATKKPGAPNFLPWQAVTLQPRSRCSAEEAGRSTSRLGIPELKDALLVAELV
Protein: Probable fatty acid methyltransferase Rv3720 (EC 2.1.1.-) (S-adenosylmethionine-dependent methyltransferase Rv3720) (AdoMet-MT) (SAM-MT) (O69687)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: May be a S-adenosylmethionine-dependent methyltransferase involved in fatty acid metabolism.
Interaction partners:
- Conserved protein
- Protein Rv3254
- Possible N-acyl-L-amino acid amidohydrolase AmiA1
- Conserved protein
Sequence:
MTTGRLSMAEILEIFTATGQHPLKFTAYDGSTAGQDDATLGLDLRTPRGATYLATAPGELGLARAYVSGDLQAHGVHPGDPYELLKTLTERVDFKRPSARVLANVVRSIGVEHILPIAPPPQEARPRWRRMANGLLHSKTRDAEAIHHHYDVSNNFYEWVLGPSMTYTCAVFPNAEASLEQAQENKYRLIFEKLRLEPGDRLLDVGCGWGGMVRYAARRGVRVIGATLSAEQAKWGQKAVEDEGLSDLAQVRHSDYRDVAETGFDAVSSIGLTEHIGVKNYPFYFGFLKSKLRTGGLLLNHCITRHDNRSTSFAGGFTDRYVFPDGELTGSGRITTEIQQVGLEVLHEENFRHHYAMTLRDWCGNLVEHWDDAVAEVGLPTAKVWGLYMAASRVAFERNNLQLHHVLATKVDPRGDDSLPLRPWWQP
Protein: Choline transporter-like protein 4 (Solute carrier family 44 member 4) (Q7T2B0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Choline transporter that seems to play a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q53GD3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53GD3}. Apical cell membrane {ECO:0000250|UniProtKB:Q53GD3}.
Interaction partners:
- X-linked retinitis pigmentosa GTPase regulator
- PDZK1-interacting protein 1.
- SKI2 homolog, superkiller viralicidic activity 2-like
Sequence:
MGKKKQEEEQNSSEYGAPAQYDPTFNGPIHKRSCTDIICCVLFMLVITGYMVVGILAWLYGDPRHVLYPRNSTGMFCGIGQNQNKPSVLYFDILKCATATNIMAAALQGLQCPTTQVCVSSCPSGFWALSPLAYLPNAKPADYFQQELCVPSLQLKDTTYTVMEIINKELCPYYYTPTTSVLDRCLPSLGGSAYNPSNIPANFSLPGLSINQTLSTIANATSDLTNSFNMKDVGLRIFEDFAKTWQWIVAGLVIAMVVSVLFLLLLRFTAPVLIWILIFGVLAVGAFGIWYCYNDYMSLASSNLTFSNVGFTTNVQVYLQVRDTWLAFLIILCIVEAVLILALIFLRTRILIAIALIQETSKALGHMMSTLLYPVVTFVLLLVCVSYWGITALYLATSGAPIYKVVALNTTQGDCSNIQANQTCDPQTFNSSRYSSCPSARCVFINYNTEGLFQRNLFNLQIYNVVAFLWCVNFVIALGHCTLAGAFASYYWAFSKPADIPTFPLTQSFMRALRYHVGSLAFGALILTLVQIVRIILEYLDHKFKAAQNPCARFLMCCLKCCFWCLEKFIKFINRNAYIMIAIYGKNFCVSAKNAFFLLMRNIVRVVVLDKVTDLLLFFGKLLVVGGIGVLAFFFFSGRIQLPGNTFQTAALNYYWMPIITVVFGAYLIAHGFFSVYNMGVDTLFLCFLEDLERNDGSAEKPYFMSKNLMKILNKKNKQPKTG
Protein: 8-demethylnovobiocic acid C(8)-methyltransferase (EC 2.1.1.284) (Novobiocin biosynthesis protein O) (Q9L9F3)
Organism: Streptomyces niveus (Streptomyces spheroides)
Function: C-methyltransferase that methylates 8-demethylnovobiocic acid to produce novobiocic acid in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases.
Interaction partners:
Sequence:
MKIEAITGSEAEAFHRMGSQASHRYDEFVDLLVGAGIADGQTVVDLCCGSGELEVILSSRFPSLNLVGVDLSEDMVRIAREYAAEQGKALEFRHGDAQLLAGMEDLAGKADLVVSRNAFHRLTRLPAAFDTMLRLAKPGGAVLNCSFIHPSDFDESGFRAWVTFLNQRPWDSEMQIVWALAHHYAPRLDDYREALAQAARETPVSEQRVWIDDQGYGVPTVKCFARRAAA
Protein: GH14572p (Growth-blocking peptide 2, isoform A) (Growth-blocking peptide 2, isoform B (EC 2.3.1.5)) (Q7K533)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GEO12066p1
- GEO08278p1
- GH20802p
- GEO10377p1
- Protein henna
- GEO07291p1
- Niemann-Pick type C-2g, isoform A
- GH18955p
Sequence:
MFLQLLSIRLAMSLILLISGQWTSARPQNPYYVENGGHGYPNHHRHHGHHVHGSGYGPGSIGPPPFVFGRFPPPPSYYPDNQPSGGRQPYYPNVGAVQGQPGSQFHQHGGGFHRGQQEYPYPVGDFNRGHPGLQQPGGDFNRGQPGFQQPGNEFNRPQPSGRAPGHQQSGSHEELPTYPRGLEPQQPGGDPNTLQPRPGQNPGGFEQPNENAGGFQQSGQNNGGFRQPSQNSGGFQQPGQSTGGFQQPGQSSGGFQQPGQSTGGFQQPGQSTGGFQQPGQSTGGFRQPDQSSGGFQQPDQNSGEFQQPGLNQGRKPGTSNNSIQPRPGSADEDFSDFNFQSPKTLQPRPGQDYETAGSGGAQTIQPIPGHPQSSVIQPIPGRAQSSDNVDQNINDLFNTHDFLSPELSTAPGANRDPKSDAEEASPESVNQRSLFNLDPKCAEGLKLMAGRCRKEA
Protein: 1,3-beta-glucanosyltransferase GAS2 (EC 2.4.1.-) (Glycolipid-anchored surface protein 2) (Q06135)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Deoxyribodipyrimidine photo-lyase, mitochondrial
- 1,3-beta-glucan synthase component GSC2
Sequence:
MNKKQNFYAAIIVAIFLCLQLSHGSSGVSFEKTPAIKIVGNKFFDSESGEQFFIKGIAYQLQRSEEELSNANGAFETSYIDALADPKICLRDIPFLKMLGVNTLRVYAIDPTKSHDICMEALSAEGMYVLLDLSEPDISINRENPSWDVHIFERYKSVIDAMSSFPNLLGYFAGNEVTNDHTNTFASPFVKAAIRDAKEYISHSNHRKIPVGYSTNDDAMTRDNLARYFVCGDVKADFYGINMYEWCGYSTYGTSGYRERTKEFEGYPIPVFFSEFGCNLVRPRPFTEVSALYGNKMSSVWSGGLAYMYFEEENEYGVVKINDNDGVDILPDFKNLKKEFAKADPKGITEEEYLTAKEPTEVESVECPHIAVGVWEANEKLPETPDRSKCACLDEILPCEIVPFGAESGKYEEYFSYLCSKVDCSDILANGKTGEYGEFSDCSVEQKLSLQLSKLYCKIGANDRHCPLNDKNVYFNLESLQPLTSESICKNVFDSIRNITYNHGDYSKSNPSRSKESLNVKYPSSEERENDGTIAFKTSGFVILLISMIAAGILL
Protein: Chromo domain-containing protein (Q54Q16)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSNNNYNYNNNNNNNNNGYGVPPILNQYQPQSLYTPPPLQQQTPPNMQSPFSTTPGMGINSMLGSGFGNSNSNNNNNNNNNNNNINNNNNNNNMVNTITSPLFNPLPPTQSNSMFSQPTLQPLQSFQPLQTLQTLQPLQQQLHQTTQIPNNNINNFNNNNSNINYNNNSNSGNNNNNNNNNNNIFNQTIPNNNSNNNNNNNNINNNNNGLKKDISNFKGNESSSSESSSESSSSEEESESQEDTPNKQRNKVLTQQLASESEEELQPVNKKKSTMVKKVDSDFESEEDVEEEQSGKDNDSDYEPSESEEQSEEDYESDTDDDDVYTKKKRGGGGRKQTASTTTTTTRSGRQAKRITYSESDSEESESDSDYEPNKKKKKQTNGRKRKGNNFQKENWTIPATRARRGKAAIDSEEESNGSDGDQFVNNVFSSSSSSDEDYSDNDKKNKKSKRTKRKNKTESDEESTITHLNLRTRGSGNIDFSIFNSDDEEGEDGSGGGGGSGSGLSTSETTNSSTAAATASSKPLIYEPADEDVIEKILDHRLKKDCSENEPEIFNVEDYEFLVKWKGWAYIHNTWDAYESLNNFKGNKKLQNYVKGILDNIQWRQEASKEDIEQADITKELMKQEIQDYTIVERVIAQREVAQSRDQIVNSTTAIDPSTGESTTTTTTTTASSSEYKSNIQYLVKWKVLAYSEVTWEYPEDIAEFQTEIDTFLIRQQNNQNAPMKANTISAKKRLDQGFTKLDTQPSWISAGTLRDYQMEGLNWLVHSWMNNTNVILADEMGLGKTIQTISFLSYLFNEQDIKGPFLVVVPLSTIENWQREFAKWAPAMNVIVYTGTGQSRDIIRLYEFYTTNRLGKKKLNFNVLLTTYDFILKDKNTLGTIKWEFLAVDEAHRLKNSESVLHEVLKLYNTTNRLLVTGTPLQNSLKELWNLLNFLMPNKFTSLKDFQDQYSDLKENDQIAQLHSVLKPHLLRRIKKDVEKSLPPKTERILRVDLSNVQKKYYKWILTKNFQELNKGKGEKTTLLNIMTELKKTCNHPYLYQNARDECELGAKDLLDSMIRASGKLVLLDKLLIRLKETGHRVLIFSQMVRMLDILADYLKGRSFQFQRLDGSMSREKRSQAMDRFNAVDSPDFCFLLSTKAGGLGINLSTADTVIIFDSDWNPQNDLQAEARAHRIGQKNHVNIYRLVSKSSVEEDILERAKQKMVLDHLVIQTMEKSQTAKSNTPNNSNVFNKEELEAILKFGAEELFKETGEEANPIEEMDIDEILSRAETREASDSTTAGEELLNSFRVANFSTTSKEEQQNATWEDIIPDADRQKAVQEEKDQLLLLGPRRRTETSSSTAPTRNISDPVVITARLKKDINQIYNKKEIKILIRSLKKFGTHKRCREILADADFQNKPLRPTEEICKEIIDAAEKAVRDNQDSDKIHLVYNGTDINATEFVQRIQDMEVLAELCQPWIKDYQQFRVTFPIRPVSWTIKWGPKEDAMLLMGIYKHGVSNWESIQKDTSLGFGDIIEIDNTAPLLDANGVPIPSNKLKGAALQRRVDSLLKSAKDISKTTNKKSSKQTKEKEEGEFKIPKKRGRKSKEIKEVSNNNHNNKETKENNNGDNNNNNNNNNSSNNRKRTTNNKYSDDDDDDDNDKDNDNDEDYMEEEEKKEKTKNTRTKKRIKSEELQKEILSPKKTSFGRLSVPPNKMGERSPSKSTTTTTTTTTSSSKSSRNSKHHSDDDDDDYRDKDSNSGRGRGRGRSSNSSSSSSSSSRNKNHESDEEDDKYYDKNLLRKCQQYLSPIKELLENFRSLSDSKVQISREEKVSKTKKYLLSLGKEISIILDEKKSANIKDLDSHLWYSASKYTASGGKELKSLYDKMKKSSSSNNDSSSSSSSRSSNSSSSNNSNSSSSSKPALKLIINKSKK
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9LYS5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MSSESSLSADMSKKVSFLGLKGMKLWVLICLVVGTFVVLVFCILSLWIAFRRKSRRSSHKLLPFSQIPRVAKDIRVDDRVGFQNHNENLSITNADKSSDRNSGKMMSYLGRTKSSDNDSISQCSSVHHHERACSSHSGEDGSFGAAWRQNSLSQGGLVTASPLVGLPEISHLGWGHWFTLRDLQLATNRFAAENVIGEGGYGVVYKGRLINGNDVAVKKLLNNLGQAEKEFRVEVEAIGHVRHKNLVRLLGYCIEGVNRMLVYEYVNSGNLEQWLHGAMGKQSTLTWEARMKILVGTAQALAYLHEAIEPKVVHRDIKASNILIDDDFNAKLSDFGLAKLLDSGESHITTRVMGTFGYVAPEYANTGLLNEKSDIYSFGVLLLETITGRDPVDYERPANEVNLVEWLKMMVGTRRAEEVVDSRIEPPPATRALKRALLVALRCVDPEAQKRPKMSQVVRMLESDEHPFREERRNRKSRTASMEIVETTEESADTSKGPGHSENTTKPEKTHV
Protein: Sequence-specific DNA binding transcription factor (F4K0Q7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein LURP-one-related 9
- FYD
- THO complex subunit 4A
- TRF-like 6
- Acyl-acyl carrier protein thioesterase ATL3, chloroplastic
- Serine/threonine-protein kinase AFC2
- RNA-binding
Sequence:
METTTPQSKSSVSHRPPLGREDWWSEEATATLVEAWGNRYVKLNHGNLRQNDWKDVADAVNSRHGDNSRKKTDLQCKNRVDTLKKKYKTEKAKLSPSTWRFYNRLDVLIGPVVKKSAGGVVKSAPFKNHLNPTGSNSTGSSLEDDDEDDDEVGDWEFVARKHPRVEEVDLSEGSTCRELATAILKFGEVYERIEGKKQQMMIELEKQRMEVTKEVELKRMNMLMEMQLEIEKSKHRKRASASVVWQGKV
Protein: Neopullulanase (EC 3.2.1.135) (P38940)
Organism: Geobacillus stearothermophilus (Bacillus stearothermophilus)
Function: Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form maltotriose.
Interaction partners:
Sequence:
MRKEAIYHRPADNFAYAYDSETLHLRLRTKKDDIDRVELLHGDPYDWQNGAWQFQMMPMRKTGSDELFDYWFAEVKPPYRRLRYGFVLYSGEEKLVYTEKGFYFEVPTDDTAYYFCFPFLHRVDLFEAPDWVKDTVWYQIFPERFANGNPSISPEGSRPWGSEDPTPTSFFGGDLQGIIDHLDYLVDLGITGIYLTPIFRSPSNHKYDTADYFEVDPHFGDKETLKTLIDRCHEKGIRVMLDAVFNHCGYEFAPFQDVWKNGESSKYKDWFHIHEFPLQTEPRPNYDTFRFVPQMPKLNTANPEVKRYLLDVATYWIREFDIDGWRLDVANEIDHEFWREFRQEVKALKPDVYILGEIWHDAMPWLRGDQFDAVMNYPFTDGVLRFFAKEEISARQFANQMMHVLHSYPNNVNEAAFNLLGSHDTSRILTVCGGDIRKVKLLFLFQLTFTGSPCIYYGDEIGMTGGNDPECRKCMVWDPMQQNKELHQHVKQLIALRKQYRSLRRGEISFLHADDEMNYLIYKKTDGDETVLVIINRSDQKADIPIPLDARGTWLVNLLTGERFAAEAETLCTSLPPYGFVLYAIEHW
Protein: Hepatic sodium/bile acid cotransporter (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (NTCP) (Solute carrier family 10 member 1) (SLC10A1) (O08705)
Organism: Mus musculus (Mouse)
Function: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q14973}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14973}.
Interaction partners:
- Solute carrier organic anion transporter family member 1B2
- Bile salt export pump
- Cytochrome P450 7A1
- Bile acid receptor
- Solute carrier organic anion transporter family member 1A1
- Prestin
- 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
- Organic solute transporter subunit alpha
- Solute carrier organic anion transporter family member 1A4
- Nuclear receptor subfamily 0 group B member 2
Sequence:
MEAHNVSAPFNFSLPPGFGHRATDTALSVILVVMLLLIMLSLGCTMEFSKIKAHFWKPKGVIIAIVAQYGIMPLSAFLLGKVFHLTSIEALAILICGCSPGGNLSNLFTLAMKGDMNLSIVMTTCSSFTALGMMPLLLYIYSKGIYDGDLKDKVPYKGIMLSLVMVLIPCAIGIFLKSKRPHYVPYVLKAGMIITFSLSVAVTVLSVINVGNSIMFVMTPHLLATSSLMPFTGFLMGYILSALFRLNPSCRRTISMETGFQNVQLCSTILNVTFPPEVIGPLFFFPLLYMIFQLAEGLLFIIIFRCYLKIKPQKDQTKITYKAAATEDATPAALEKGTHNGNNPPTQPGLSPNGLNSGQMAN
Protein: Fetuin-B (16G2) (Fetuin-like protein IRL685) (Gugu) (Q9UGM5)
Organism: Homo sapiens (Human)
Function: Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Meprin A subunit alpha
- Astacin-like metalloendopeptidase
Sequence:
MGLLLPLALCILVLCCGAMSPPQLALNPSALLSRGCNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQDCGMRIFFESVYGQCKAIFYMNNPSRVLYLAAYNCTLRPVSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQKPTNLPKVEESQQKNTPPTDSPSKAGPRGSVQYLPDLDDKNSQEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEEKLVVLPFPKEKARTAECPGPAQNASPLVLPP
Protein: Ras-related protein Rab-1B (EC 3.6.5.2) (Q9H0U4)
Organism: Homo sapiens (Human)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11389151}. Membrane {ECO:0000269|PubMed:11389151}; Lipid-anchor {ECO:0000269|PubMed:11389151}; Cytoplasmic side {ECO:0000269|PubMed:11389151}. Preautophagosomal structure membrane {ECO:0000269|PubMed:20545908}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P10536}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments (PubMed:11389151). In the GDP-form, colocalizes with GDI in the cytoplasm (PubMed:11389151). Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:11389151}.
Interaction partners:
- TBC1 domain family member 20
- Ras-related protein Rab-1A
- Rab GDP dissociation inhibitor beta
- Rab GDP dissociation inhibitor alpha
- Golgin subfamily A member 2
- Guanine nucleotide exchange factor MSS4
- Trafficking protein particle complex subunit 8
- Trafficking protein particle complex subunit 1
- Trafficking protein particle complex subunit 4
- Trafficking protein particle complex subunit 5
Sequence:
MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGIPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGERPNLKIDSTPVKPAGGGCC
Protein: Actin-related protein 2/3 complex subunit (A0A1D8PT60)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cytoplasm, cytoskeleton, actin patch {ECO:0000256|PIRNR:PIRNR038093}.
Interaction partners:
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 5
- Actin-related protein 2/3 complex subunit 3
- Arp2/3 complex 34 kDa subunit
- Actin-binding protein
- Actin
- SPIN90/Ldb17 leucine-rich domain-containing protein
- Centractin
Sequence:
MSKVPAIYQLGHLPIKDHVFSPDRSILAITKGNDVEVYQISPSNLSSKPQLIAVLKDHDKTVTSVDISPDGSKILTCSQDRNALVWEYANGEYKPTLVLLRINRAATVCRWSPDGSKFAVGSSDRIIAVCYYEEENDWWVSKHLKKPLKSTITTIDWHPNGVLLACGSTDGHVRVFSGYIKGIDAKPDPSVWGTKLPFQTLCGDYTNETNAWIHGVKFSPDGNALAYVSHDSSVGFVYPQGEGLPPRAIFNVKTDNLPFKSVVWLNDQQVCAGGFTCNLVVFQGDEHGWQQAYQVEEQKDLTKEVPHSKLGEGDDDDEEISSHQALNMFKQMDLKGRVSKPSAGGKPAKALNTIHQNTINSIRNFDQGRVSTSGIDGKVVIFNV
Protein: Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) (P22935)
Organism: Mus musculus (Mouse)
Function: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10490651}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10490651}. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Interaction partners:
- Retinoic acid receptor beta
- Retinoic acid receptor alpha
- Retinoic acid receptor gamma
- Cytochrome P450 26C1
- Arginine--tRNA ligase, cytoplasmic
- Peroxisome proliferator-activated receptor delta
- Cytochrome P450 26A1
- Retinoic acid receptor RXR-alpha
Sequence:
MPNFSGNWKIIRSENFEEMLKALGVNMMMRKIAVAAASKPAVEIKQENDTFYIKTSTTVRTTEINFKIGEEFEEQTVDGRPCKSLVKWESGNKMVCEQRLLKGEGPKTSWSRELTNDGELILTMTADDVVCTRVYVRE
Protein: Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)] (P77399)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long-chain fatty acids.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Acyl-coenzyme A dehydrogenase
- 3-ketoacyl-CoA thiolase FadA
- Acetyl-CoA acetyltransferase
- 3-ketoacyl-CoA thiolase FadI
- Probable acetyl-CoA acetyltransferase
- Fatty acid oxidation complex subunit alpha
- 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase
- Methylmalonyl-CoA decarboxylase
- Acetate CoA-transferase subunit beta
- Acetate CoA-transferase subunit alpha
Sequence:
MEMTSAFTLNVRLDNIAVITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFVSAKPDNFIAGADINMIGNCKTAQEAEALARQGQQLMAEIHALPIQVIAAIHGACLGGGLELALACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALKLGLVDDVVPHSILLEAAVELAKKERPSSRPLPVRERILAGPLGRALLFKMVGKKTEHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRSIFFASTDVKKDPGSDAPPAPLNSVGILGGGLMGGGIAYVTACKAGIPVRIKDINPQGINHALKYSWDQLEGKVRRRHLKASERDKQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQNCAAHTIFASNTSSLPIGDIAAHATRPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATTVKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTQGERVEHIDAALVKFGFPVGPIQLLDEVGIDTGTKIIPVLEAAYGERFSAPANVVSSILNDDRKGRKNGRGFYLYGQKGRKSKKQVDPAIYPLIGTQGQGRISAPQVAERCVMLMLNEAVRCVDEQVIRSVRDGDIGAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVEMGARGESFWKTTATDLQ
Protein: AT-rich interactive domain-containing protein 6 (ARID domain-containing protein 6) (C0SUW7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
Interaction partners:
Sequence:
MVDTEMQEQDVTFGALVETKYLEEEPLEPENDHNPSEIPQPLLLGDGQANNGHGMNGGAVGVVDHSERKTRRVQMLSPKTEGENAKKRKTWLLDSEAQGTDEAGTPVEQVAFLREVEAFYKESFLEFKPPKFYGQPLNILKLWRAVVNLGGYEVVTTNKLWRQVGESFNPPKTCTTVSYTFRNFYEKALLEYEKCLRNNGELNLPGSTLILSSSVEKEPSSHQGSGSGRARRDSAARAMQGWHAQRLVGSGEVTAPAVKDKGLISTPKHKKLKSIGLQKHKQQTSMDHVVTNEADKQLAAEVVDVGPVADWVKINVKESKDSFEIFALVPGLLRKEVRIQSDPAGKVVITGQPEQLDNPWGITPFKKIVDLSARIDPLHTSAVMSMHGRLFIRVPFEQ
Protein: Ahnak protein (A0PJF4)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
TRPVDVSLPKVEGDLKGPEVDIKGPKMDISAPDVDVHGPDWHLKMPKVKMPKFSMPGFKGEGPEVDVNLPKADLDVSGPKVDIEGPNVNIEGPEGKLKGPKFKMPDLHLKAPKISMPEIDLNLKGPKLKGDVDVSLPKVEGDLKGPEVDIKGPKVDISAPDMDVHGPDWHLKMPKMKMPKFSMPGFKAEGPEVDVNLPKADIDVSGPKVDIDVPDVNIEGPDAKLKGPKFKMPEMNIKAPKISMPDFDLHLKGPKVKGDVDASLPKMEGELKGPGIDIKCPTVDIDTPDVNIEVPEGKLKGPKFKMPDMHIKAPKISMPDFDLNLKGPKVKGDVDLALPNVEGDLKGPEIDIEGPEGKLKGPKFKVPDVQFKTPQISMSDIDLNVKGPKIKGDLDISIPKPEGDLKGPKVDIKGPKLDIDTPDIDIHGPEGKLKGPKFKMPDLHLKAPKISMPEVDLNLKGPKVKGDVDVSLPKVEGDLKGPEVDIKGPKVDISAPDVDVHGPDWHLKMPKVKMPKFSMPGFKGEGPEVDVSLPKANIDVSGPKVDIDVPDVNIEGPDAKLKGPKFKMPEMNIKAPKISMPDIDLNLKGPKVKGDVDVSLPKVEGEIKVPEVDIKGPKVDIDVPDVDVHGPDWHLKMPKVKMPKFSMPGFKGEGPEVDVNLPKADLDVSGPKVDIDVPDVNVEGPDMKVKGPKFRMPEINIKAPKISMPDVDLELKGPKVKGAFDGSVPKIEGTLKGPEIDMKGPGLDFEGPDAKLSGPNLKMPSLEVSVPKITGPDANVHLKTPKVGISAPKLGGGEVDLKGPKVDLETPSLDVHMESPDINIEGPDVKVPKFKKPKFGFGAKSPKADIKTPTVDVTVPEAELNVDSPEINIGGKSKKSKFKMPKIHMSGPKVKAKKQGFDLNIPGGEIDTSLKAPDVDVSVAGPDAALKAEVKSPKVKKTMFGKMYFPDVEFDIKSPKFKAEAPLPSPKLEGEIKVPDVDISSPGINVEAPDIHMKAPKFKVPGVEASGPKIEGNLKGPKVQANLDTPDINIEGPEAKIKAPSFSVSAPQVSIPDVNVNLKGPKIKGDVPSVGLEGPNIDLQGPEGKIKFPKFSLPKISAPGVKMEGGSTEIGAQMPSLEGGLSTSDMKLEGPHLSLKGPGVDLPSVDLSMPKVSGPDLDMNLKGPSLKGDLGASSPSMKLHAPGLDLKGVGGKVHIGADGVKMSGIDATTALSVGAPDVTLKGPSLQGDLAVSGDIKCPKVSVATPDVSLEASEGAVKLPHMKLPQFGISTPGSDLDINIKGPQVCGELKGSGMDVNLKGPQISAPSMDFNLEGPKVKGSLGAAGELKGPAIGGALPGISIQGPEGNLQMPGIKASGCDVKLSSGQISGPEIKGDLKGSGLGLHGAVPDIGVKGPSFNVASPESDFGVSLKGPKVKGGVDVSGGVSVPDINLGEGHMSVKGSGVEWKGPQVSSSLNLDTSKLAGNLHFSGPKIEGDVKGGQTGLQGPGLSVSGPQGHLESESGKVTFPKMKIPKFTFSGRELIGREVGVDVNFPKVEANVQAGAGEGKWEESEVKLKKKKK
Protein: Uncharacterized protein (O07774)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MIRRRGARMAALLAAAALALTACAGSDDKGEPDDGGDRGASLATTSDADWKPVADILGRTGKLNDGSVYKIGFARSDLSVQTKGVTVAPALSLGSWVAFARTPDGQTMLMGDLVVTEDELASVTDAVQAGGLQQTALHKHLLEQSPPIWWTHIAGHGDAADLARAVRSALDATDTPPPASATSGQTSLDLDTAAIDEALGRSGTIAGGVYKFFIARRDPVTMSGMLIPPSMGLATALNFQPTGNGRAAINGDFVMTAAEVQDVVQALRGGGIDIVAIHNHGFDEQPRLFYMHFWAENDAVALARTLRAAVDATAAR