wanglab/gogpt-training-data huggingface dataset:
Protein: Dizzy isoform CII (PDZ domain-containing guanine nucleotide exchange factor, isoform C) (B7Z026)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MDPYHHIRHHYPPTSIAGTGVVVGSSTTINRPELHQKCNRGSHSSDTSSAYSGSDTMASNYASSLEAEEIDLSGLVESVVDSDEEDLAESMDSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSSLNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGGSISGGAGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSDHQRRQMHNNGPKFGTASPQAVKKMLSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGFSTPSPGGVVTSPATSAVANVQCTPSPSPCSHRRLASGGNIIPSRAIHERSHSDTPAPPPPLPSVDLSLESSSVTTFRDLPLRKSVTSGGPPNFMDSTKCTICPMPPMNQ
Protein: Probable LRR receptor-like serine/threonine-protein kinase At4g31250 (EC 2.7.11.1) (C0LGR9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Serine/threonine-protein kinase RHS3
- Calcium-dependent protein kinase 25
- Protein ROH1A
- Serine/threonine-protein kinase AGC1-5
- Serine/threonine-protein kinase AGC1-7
- Probable E3 ubiquitin-protein ligase LOG2
Sequence:
MTRDDKFPIVYSLLLIVLLFVSPIYGDGDADALLKFKSSLVNASSLGGWDSGEPPCSGDKGSDSKWKGVMCSNGSVFALRLENMSLSGELDVQALGSIRGLKSISFMRNHFEGKIPRGIDGLVSLAHLYLAHNQFTGEIDGDLFSGMKALLKVHLEGNRFSGEIPESLGKLPKLTELNLEDNMFTGKIPAFKQKNLVTVNVANNQLEGRIPLTLGLMNITFFSGNKGLCGAPLLPCRYTRPPFFTVFLLALTILAVVVLITVFLSVCILSRRQGKGQDQIQNHGVGHFHGQVYGQPEQQQHSEKSSQDSKVYRKLANETVQRDSTATSGAISVGGLSPDEDKRGDQRKLHFVRNDQERFTLQDMLRASAEVLGSGGFGSSYKAALSSGRAVVVKRFRFMSNIGREEFYDHMKKIGRLSHPNLLPLIAFYYRKEEKLLVTNYISNGSLANLLHANRTPGQVVLDWPIRLKIVRGVTRGLAYLYRVFPDLNLPHGHLKSSNVLLDPNFEPLLTDYALVPVVNRDQSQQFMVAYKAPEFTQQDRTSRRSDVWSLGILILEILTGKFPANYLRQGKGADDELAAWVESVARTEWTADVFDKEMKAGKEHEAQMLKLLKIGLRCCDWDIEKRIELHEAVDRIEEVDRDAGGGQESVRSSYVTASDGDHRSSRAMTEEFSLM
Protein: Sel1-repeat-containing protein YbeQ (P77234)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized J domain-containing protein DjlB
- Uncharacterized protein YbeU
- Uncharacterized protein YbeR
- Sel1-repeat-containing protein YbeT
Sequence:
MIFTSSCCDNLSIDEIIERAEKGDCEAQYIVGFYYNRDSAIDSPDDEKAFYWLKLAAEQGHCEAQYSLGQKYTEDKSRHKDNEQAIFWLKKAALQGHTFASNALGWTLDRGEAPNYKEAVVWYQIAAESGMSYAQNNLGWMYRNGNGVAKDYALAFFWYKQAALQGHSDAQNNLADLYEDGKGVAQNKTLAAFWYLKSAQQGNRHAQFQIAWDYNAGEGVDQDYKQAMYWYLKAAAQGSVGAYVNIGYMYKHGQGVEKDYQAAFEWFTKAAECNDATAWYNLAIMYHYGEGRPVDLRQALDLYRKVQSSGTRDVSQEIRETEDLL
Protein: Hyposin-H6 (HPS-H6) (Hyposin HA-6) (P86921)
Organism: Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa hypochondrialis)
Function: Antibacterial peptide active against X.axonopodis pv. glycines (MIC=42 uM). Not active against E.coli ATCC 25922, S.aureus ATCC 29313 or P.aeruginosa ATCC 27853.
Subcellular location: Secreted {ECO:0000269|Ref.1}.
Interaction partners:
Sequence:
LRPAILVRVKGKGL
Protein: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (EC 1.2.4.1) (Q7K5K3)
Organism: Drosophila melanogaster (Fruit fly)
Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity). Might play a role in regulating synapse structure formation at neuromuscular junctions. Might play a role in maintenance of mitochondrial morphology.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:29501567}.
Interaction partners:
- Dihydrolipoyl dehydrogenase
- Pyruvate dehydrogenase E1 component subunit alpha
- 2-oxoisovalerate dehydrogenase subunit alpha
- Pyruvate dehydrogenase E1 component subunit alpha
- dihydrolipoyllysine-residue acetyltransferase
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- Pyruvate carboxylase
- Uncharacterized protein, isoform E
- Pyruvate kinase
Sequence:
MLRTRLIQAASSAQRAFSTSQKALAAKQMTVRDALNSALDDELARDDRVFILGEEVAQYDGAYKVSRGLWKKYGDKRVIDTPITEMGFAGIAVGAAMAGLRPVCEFMTWNFSMQAIDHIINSAAKTFYMSAGAVNVPIVFRGPNGAASGVAAQHSQCFAAWYAHCPGLKVLSPYDAEDARGLLKSAIRDPDPVVFLENELVYGTAFPVADNVADKDFLVPIGKAKVMRPGKDITLVAHSKAVETSLLAAAELAKKGIEAEVINLRSIRPLDTATIFASVRKTHHLVTVENGWPQHGVGAEICARIMEDQTFFELDAPVWRCAGVDVPMPYAKTLEAHALPRVQDLVEATLKVLGGKVGKAAAANK
Protein: BILBO1 N-terminal domain-containing protein (Q584W7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
Sequence:
MMGGISICVATDCDGEKVNLRFLFDAAGPSVSRLLNYSTTAFNNYFRLKGISRAFAVNSAVVFNDVHCTWDRLERTTQLLHNSQVYLFQPDTLDIPAAIPEPYEGEPLLSADCYLPLRGATISTPIPAIKRIAPQRFASPKGGEKTRFSSPLMFRWAGANKSPVGFRRTNSVSFDDCVNDRSRHNRSCSHSFSKDIHSTGISDDSSYLLHQNGGRGTDKHYSSFSSGGSILREEREKIEFQLSLPLDEMRRCVREETRRLDTTISTPIKRI
Protein: Protein O-mannosyl-transferase TMTC1 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 1) (Transmembrane and tetratricopeptide repeat-containing 1) (Q3UV71)
Organism: Mus musculus (Mouse)
Function: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IUR5}.
Interaction partners:
Sequence:
MLVTRGDRGGGERAPSRRPRCGLVPAGAAALLAGASCLCYGRSLRGEFVHDDVWAIVNNPDVRPGTPLRWAIFANDFWGKGLADSTSHKSYRPLCVLSFRLNIFLTGMNPFYFHAVNVILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPVHTEAVAGIVGRADVLACLLFLLAFLSYQRSLDQGCAGQCFPTTASPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSPSHKQDKLSNGAVCQHSSGQPGSPQPSSQQAHPHRESRKQRFPHKDSWGGCHSPLPPEPKSSGFPMSPRAMWSLMRCLTGSTNRNFLLTLRPFLKRAILVISYVTVILYFRLWIMGGTMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPITLCYDWQVGSIPLVETIWDVRNLATILLAVVMALLSLHCVAAFKRLEHKEVLAGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCAGLSRCGATSLMASTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTKDMAEAKMYYQKALQLHPQHNRALFNLGNLLKSQEKTEEAIMLLKESIKYGPDFADAYSSLASLLAEQERFKEAEDIYQAGIKNCPDSSDLHNNYAVFLVDSGFPEKAVAHYQQAIQLSPSHHVAVVNLGRLYRSLGENSKAEEWYRRALKVARTAEVLSPLGALYYNTGRHKEALEVYREAVSLQPSQRELRLALAQVLAVMGQTKEAEKITSHIVSEEPRCLECYRLLSAIHSKQEHHGKALEAIEKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYEAAVTLDPDQAQAWMNMGGIRHIQGSYVSARAYYERALKLVPDSKLLKENLAKLDRLERRLQEVRERDQT
Protein: Myosin-14 (Q2YQA7)
Organism: Brucella abortus (strain 2308)
Interaction partners:
- TIGR02301 family protein
- DUF1254 domain-containing protein
- Uncharacterized protein
- Invasion associated locus B family protein
- Kinesin
- DUF459 domain-containing protein
- Flagellar export protein FliJ
- DUF1134 domain-containing protein
- Zinc finger CHCC-type domain-containing protein
- DUF1214 domain-containing protein
Sequence:
MIQSALFLMLGVLVAVFVVVLLGPSVWRRAFFLARRQVQAELPITLAEIRADRDGLRAEHAVAVSKLEQLLKLERGKTAEQKVTLARQQDELKRIPLLEQNIARLEKRLGEEEKGAAEARQARDTALEKAEILQAELERVQGHYVALESLADTLRIEISAHEAEISRLMSEITEMRHDRKDATARYNELSTQLTAAQTKLKSETRRNGELQQKLEKLISELSDAQEKLERQNRHGDGALMSADQIEIARQNAALREEMATLAARMVAITAEREGPDSPIHKLLKGTALTEKGKGKKNKAPKSLATRIRDMQ
Protein: Uncharacterized protein (Q382T5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- BRCT domain-containing protein
- Uncharacterized protein
Sequence:
MFYASEEGLRTAELAGRMFYNLGINSHGELQDIHQLHTGHVGGACLDNDIEAAYLGGRNRSSAYQPSGQRCKGDPNANLVVEVARRESVLRQVYNDKLRGSIQAIITALADELPRDHIFLQLLNDASTQQYCRVRVGEVVEAFLFSVQAHQYHNLASELAKREVELLALASQLEMAEKQPHVSLTPGSVKSTQTESYEESNGVTEENTPSCRGTVVGDATDAQAELFGLLDEMTREHELAKFRECLSAPTSLLETVQAVDKYADRYEYLSDIVSHLFRSIRCLVMYAEGSLNSISALRRGSHNVRGVGGSRGASAGRESSSPQSPEQHTTEEWQPLTLGGSPPQKEQRDWQNAEVLRGERNRLRTLVVRLKHAESHCGNLIQSMSTCHMDLRKRSEVVKQQTQRLAPGSILNVFTDVSRGNEEVLEKLDGNIHKTIVTRRNKADECHKEQQEHLVQCTIELQEAHKSLAVARQRLQVETEKRELTDQRLRDAVKQLKLVEQELQLEREARAVMQQKSRESEELPVRQALEVAEEMDRLRMQLRAERVSVVNHRAEAVCAQLECAVLKAYTAKMDLLQQHGYMWAVLEQRHAVLLSQEELRHTRNQASSTTLTLREQEEVMQHCCEDLCQLLRCMQRDEDQVESRQRALEDGTEARRLAMVVRSDRGDDENGKKNDSEQVSPSCDNIDGQQRVEEDHEEGQEAVWRRYRTPKTLPGVVAGLQITYSALQRRHLDVQSIADAAQSCVQQQREELASLHAQLRNLATDYGRQREELKQLWDKQAEWSQQDTLKGLLAKQKSLLAAVDKEREELHRRWAALNEEYQTLERRNSQLHERCAVKEVENARLMGVLRVKHIAPSTSSIGSDSTCNDCFTSQTADTLRPLHISSPFRPSVVVPTAPSTDNTGSPEACGGSASQTPQKRTSGIVTVATTPLNDRHDEPVPLCEKHPQVLGTPDWSNNVRKVPSRVTDAGNVVGEGRMVLPQQEQEVVRHGAEAIHSCGGSPPACPNPLAEGLGGGTGNMRRGVVA
Protein: Uncharacterized protein Hag2 (Q68BG2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MQQTGFRGEAEQAPGAGRQALPSPGTGFSTHRWKLQEILLRRPSVQTTCSGQCRCTVVCTLVRLGKGQQRHGRLGTQCAASKERTAGCSFVESHIQCFSSQVLQTRDQEALRDSARGEDCSREDQRVRPLGLRTWSVIGELDRDPITCVKTLETLS
Protein: Catalase (EC 1.11.1.6) (P24270)
Organism: Mus musculus (Mouse)
Function: Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
Subcellular location: Peroxisome matrix {ECO:0000269|PubMed:2868912}.
Interaction partners:
- 2-Hydroxyacid oxidase 1
- 2-Hydroxyacid oxidase 2
- Kynureninase
- 3-hydroxyanthranilate 3,4-dioxygenase
- Ribonuclease P protein subunit p14
- Sterol carrier protein 2
- Trehalase
- Superoxide dismutase
- Hydroxysteroid dehydrogenase-like protein 2
- Superoxide dismutase, mitochondrial
Sequence:
MSDSRDPASDQMKQWKEQRASQRPDVLTTGGGNPIGDKLNIMTAGSRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYSKAKVFEHIGKRTPIAVRFSTVTGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDAILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNADGEAVYCKFHYKTDQGIKNLPVGEAGRLAQEDPDYGLRDLFNAIANGNYPSWTFYIQVMTFKEAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNKNPVNYFAEVEQMAFDPSNMPPGIEPSPDKMLQGRLFAYPDTHRHRLGPNYLQIPVNCPYRARVANYQRDGPMCMHDNQGGAPNYYPNSFSAPEQQRSALEHSVQCAVDVKRFNSANEDNVTQVRTFYTKVLNEEERKRLCENIAGHLKDAQLFIQKKAVKNFTDVHPDYGARIQALLDKYNAEKPKNAIHTYTQAGSHMAAKGKANL
Protein: CDKN2A-interacting protein (F1QZX8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
- 5'-3' exoribonuclease
- Translocated promoter region a, nuclear basket protein.
- Prothymosin alpha-A
Sequence:
MAARRGEDIVSEFLSQNPHLVSWVESLRGHCETNKQWYARREFVLRNMEAFPTIQPGSPSSSLDRLLSLSMVWANHVFLGCRYPQRVMDKINEMAEGITVIEAPERKTRDEIMGKLKRPAVSAADADYQGKKTKPNEPDDRAHSKCVVHPATSSHKCGPSPGAPAEHQPFFNRLYKAVAWKLVSAGGFGPNLEHFEILRSCVESCKASLTCVFVPLKDIPDLPAGRTQREGQVCELRCCTVYMGTGYGRDESAARAMASKEALKVFQGQKVTVKISRRRFRGRDVDDLVLLDEQSRSQAFPPALSCPFQEDE
Protein: NifU-like protein 4, mitochondrial (AtNfu-III) (AtNfu4) (Q9LIG6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12553879}.
Interaction partners:
- Iron-sulfur cluster assembly protein 1
- Bifunctional monothiol glutaredoxin-S16, chloroplastic
- Cysteine desulfurase, mitochondrial
- Fe-S cluster assembly factor HCF101, chloroplastic
- Monothiol glutaredoxin-S14, chloroplastic
- Monothiol glutaredoxin-S15, mitochondrial
- SufE-like protein 1, chloroplastic/mitochondrial
- Iron-sulfur cluster assembly protein 2
- Dihydroxy-acid dehydratase, chloroplastic
- Iron-sulfur assembly protein IscA, chloroplastic
Sequence:
MKGIARLVTSLSRIGGRKVVSGTSTVTSSSSSSLLLSRRSLFISATNLLNSRTKDSALPSLNSSLLAQKWNFLGGQRRTMFIQTQSTPNPSSLMFYPGKPVMEVGSADFPNVRSALGSPLAKSIYSIDGVVRVFFGSDFVTVTKSDDVSWDILKPEIFAAVMDFYSSGQPLFLDSQAAAAKDTAISEDDSETVAMIKELLETRIRPAVQDDGGDIEYCGFDPESGIVKLRMQGACSGCPSSSVTLKSGIENMLMHYVSEVKGVEQEFDGEDEEGTLSGEMRVE
Protein: Cytochrome P450, family 707, subfamily A, polypeptide 1 (A8MRX5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MDISALFLTLFAGSLFLYFLRCLISQRRFGSSKLPLPPGTMGWPYVGETFQLYSQDPNVFFQSKQKRYGSVFKTHVLGCPCVMISSPEAAKFVLVTKSHLFKPTFPASKERMLGKQAIFFHQGDYHAKLRKLVLRAFMPESIRNMVPDIESIAQDSLRSWEGTMINTYQEMKTYTFNVALLSIFGKDEVLYREDLKRCYYILEKGYNSMPVNLPGTLFHKSMKARKELSQILARILSERRQNGSSHNDLLGSFMGDKEELTDEQIADNIIGVIFAARDTTASVMSWILKYLAENPNVLEAVTEEQMAIRKDKEEGESLTWGDTKKMPLTSRVIQETLRVASILSFTFREAVEDVEYEGYLIPKGWKVLPLFRNIHHSADIFSNPGKFDPSRFEVAPKPNTFMPFGNGTHSCPGNELAKLEMSIMIHHLTTKYRFGQLLERATGFSMGHSRFPKTDCPLCWPGSRRSKCRMTELPLAFLYLERGD
Protein: DNA-directed RNA polymerase I subunit RPA1 (TbRPA1) (EC 2.7.7.6) (DNA-directed RNA polymerase I largest subunit) (P16355)
Organism: Trypanosoma brucei brucei
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250}.
Interaction partners:
Sequence:
MSGIAFVEVRTRAGQEDRSAPWRPVVRNGENHATFYDTRMGNFDANPFPPQTCQTCAASLTGKYGNERCHGHFGFVGMPRIRPGSAHSDSDRLVVLNPHLAMDADRLFRAKCFFCHKFRAPTFDVERFRQALVLADHGLPGDALHLLDTVPTAKGHDAMLNHRRMANEEIVNDVSILQSYVDRILRQRASGCSEEDAKARVTMAQKGTVDVRNDICNMAISHLRSFSGPCSHCTAISPTFLKRGGIIFFLFRKSNLVTNIAKGFLTQQEVSEWEAVNRLHGRTGTYFDGRQMLFHMKNLFAKEQAILGLLYPNLGEPSVFTKTNKVVPASERYKLFFLDRILVPPLPLRLSSGVRVNDNGLIIPDEQTRALSDILGFVEQIECFHTLSANSTNGRSFITDAQRAVNESNLRNLQQKVDEFYAEIVNSFAKKEGLFRMNMMGKRVNQACRSVISPDPFVEPNEVLLPRPLARALSFPEQVTCFAPARMNLLKHCVVNGPRKYPGATHIELRHANGEIRSVDLNVPEQTRRQHAARFFAMAQSGVTLIVYRHILNGDRVIFNRQPTLHKPSMMGYRVKVLSGSKTIRFHYVNGNSFNADFDGDEMNVHVPQSIETRAEVETLMDANINYLVPTSGRPIRGLIQDHVAAGVLVTLRDKFFDHSTFVQLVYNGVGPYIQENVGITLAELIPIPAILMPRPMWTGKQLISVMVRFSSGLSAASDCGREIEGGITLKGTSQIQPSAFDRIPAGSCDAVRAKSGAVVDSTVMFANSELITGFMCKKQLGASNMSAPHHVYELYGPHRTGQLFAAFGRVLLLALRKEGLSLAMDDMFLVDEERRCDLLRKLDDIALDVPDEEATAAPMIADYATKIQQEFVPQRMLVPFPKNHLLLMTISGAKGSNLNATQMSLQLGQQLFDGLRVKRMNSSKTLPSFFTNEKRARSFGFAMGSFASGIRPAEYTIHAMAGRDGLIDTAVKTSRSGHLQRCLIKGLESLVVHWDRTVRDSNGSVIQFMYGGDGLDPCKASTLTAWEMMKDNVVDVSKRFGGDASESVAGAEDGAAAGLKEMRNEDGKPTTEAVQNAHMEQQLSTYPLPASLDKSLSEYLCKKADFPLFRKVSTLARWDAKQQLKERLQQRRQKWVGAFEKTLADITARRRLWALCEPGEPVGLLAAQAAGEPSTQMTLNTFHTAGSTVSHVTEGIPRLRELLIYASVNKAAVVVPVTNATEEDEKVIAKMLRAGVAAKLTDCLAKVTDGAGGQSASSSMQRNLNTGFGKGYHYHVARGRTGMVITVSFLFSRSCLEELRKRMCMSPSEHRQSFTEALKNVVRLIMRSLSAVPREKESGDGSGNTGGMKGGSGRADRKRKRSGPDDGGGPLGGTFGDEIMRIEEGTDSDDGMSERSSIGGGRAGSEVSSLHSDGTDTRGIAGSDTGGPQRRRGSVESGRGDDASDSEAADPDLYARRSGSPARDAEDGGEMQDRDGTDWGGTSMQGVVGYDNFPEIHMSFTKSNFGAVIAPLSTAAAARDGVVQLHEDFFIVNAVLRTASDVIAVIPDVVDNALEAQRMPSWLPQFGSLTFTRLKDKGSGQLVFQGPGSTMRNVMSFLSLFTVGIKSIKLHQACSTDIRDMGTYFGIESGYAALYDELNKLFNRYNVDPRHLSLIADTSTHRGRWENFNFTGVISTSASPLFQMTFASSKRWLHRAVSRGMSDDLESFSSAIMVGERPRVGTASVRLSTDTAILRDVLERNFA
Protein: Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1) (Q920L1)
Organism: Mus musculus (Mouse)
Function: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (Probable). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells. Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A4UVI1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A4UVI1}. Mitochondrion {ECO:0000250|UniProtKB:O60427}.
Interaction partners:
- Very long chain fatty acid elongase 5
- Very long chain fatty acid elongase 2
- Very-long-chain enoyl-CoA reductase
- Very-long-chain 3-oxoacyl-CoA reductase
- Very-long-chain
- Very-long-chain
- Very-long-chain
- Very-long-chain
- Acyl-CoA desaturase 1
- Very long chain fatty acid elongase 6
Sequence:
MAPDPVPTPGPASAQLRQTRYFTWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSRVISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPSFEPTKNKALTDEFRELRATVERMGLMKANHLFFLVYLLHILLLDVAAWLTLWIFGTSLVPFILCAVLLSTVQAQAGWLQHDFGHLSVFGTSTWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPLFFALGKVLPVELGREKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWVDLAWMLSFYARIFFTYMPLLGLKGFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNVDWVSTQLQATCNVHQSAFNNWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKYGIKYESKPLLTAFADIVYSLKESGQLWLDAYLHQ
Protein: AT4g05150/C17L7_70 (Octicosapeptide/Phox/Bem1p family protein) (Q940N7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKSNQKKQKSPNYQNPRRQRGEIEREKEAKIMASIPPPELDNDSLASSPRSEYDSQPRVRFMCTFGGRILPRPPDNQLCYVGGDNRMVAVHRHTTFASLLSKLAKLSGKSNISVKYQLPNEDLDALISVSTDEDVENMMDEYDRVAQNQNPRASRLRLFLFTKNVAGEEDNDSRASSISSLLDSSVNREQWFLDALNLGSSAAATAVSNGGSGRVFERVRSEVSSIVSEVPDYLFGLDNFDETAPPHELRDRDPRAKIQREVSTLSDPGSPRRDVPSPYGSTSSAPVMRISTPELPPPVFIKPESPEPVSTPKSNPQPEQVMQQSNLPVNSQWQYAPGPGQQVHYQGHTIHQSPVYYVPGSVPGNHMVQQGNHMVQPGNHMVQPVQMPGQYLQQYHHVPMGYHQPQTHQMAGPGQVYGGTVRPVMMAVDGMNRTGYYGMKTPGPVQMYQHHTGMVVPGVEEQQQYRTETDSDTGRAS
Protein: 60S ribosomal proteins L38, putative (Q38BR9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 60S ribosomal protein L27, putative
- 60S ribosomal protein L39, putative
- 60S ribosomal protein L29
- 60S ribosomal protein L5, putative
- 60S ribosomal subunit protein L31, putative
- 60S ribosomal protein L35A, putative
- 60S ribosomal protein L17, putative
- 60S ribosomal protein L13a, putative
- 60S acidic ribosomal protein P0
- 60S ribosomal protein L10, putative
Sequence:
MPREIKNLKEFLAICSRKDVRCVKVKHNPKVTKFKVRCSRYLYTLVMADKKKADKIERSIHPTVKKITVTARSHAKKNTPSK
Protein: Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) (P33317)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Interaction partners:
- Thymidylate synthase
- Deoxycytidylate deaminase
- Inosine triphosphate pyrophosphatase
- Nucleoside diphosphate kinase
- Thymidylate kinase
- Uracil-DNA glycosylase
- DNA-
- Proliferating cell nuclear antigen
- Apurinic-apyrimidinic endonuclease 1
- Ty transcription activator TEC1
Sequence:
MTATSDKVLKIQLRSASATVPTKGSATAAGYDIYASQDITIPAMGQGMVSTDISFTVPVGTYGRIAPRSGLAVKNGIQTGAGVVDRDYTGEVKVVLFNHSQRDFAIKKGDRVAQLILEKIVDDAQIVVVDSLEESARGAGGFGSTGN
Protein: Serine and arginine repetitive matrix 1 (M0R088)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRMQMGKRWQSPVTKSGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSP
Protein: At5g14105 (Q8LEU9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g68680
- MICOS complex subunit, putative
- At2g28430/T1B3.5
- NADH dehydrogenase 1 alpha subcomplex subunit 1
- Mitochondrial import inner membrane translocase subunit TIM22-1
- NADH dehydrogenase 1 alpha subcomplex subunit 8-A
- Transmembrane protein
- NADH dehydrogenase 1 beta subcomplex subunit 3-A
- NADH dehydrogenase 1 beta subcomplex subunit 8
- NADH dehydrogenase 1 beta subcomplex subunit 2
Sequence:
MGLTNFILTVAGVGAVVMLLRSDVKQSVTVLRRNVKHIRHWLEEESSAASSKAAESIKPKEIEVKVPKKDIPKEKD
Protein: Eukaryotic translation initiation factor 2 subunit alpha (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) (P20459)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56286}.
Interaction partners:
- eIF-2-alpha kinase GCN2
- Eukaryotic translation initiation factor 3 subunit B
- Translation initiation factor eIF2B subunit delta
- Small ribosomal subunit protein uS7
- Eukaryotic translation initiation factor 5
- Translation initiation factor eIF2B subunit gamma
- Eukaryotic translation initiation factor 2 subunit gamma
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS5
- Eukaryotic translation initiation factor 3 subunit A
Sequence:
MSTSHCRFYENKYPEIDDIVMVNVQQIAEMGAYVKLLEYDNIEGMILLSELSRRRIRSIQKLIRVGKNDVAVVLRVDKEKGYIDLSKRRVSSEDIIKCEEKYQKSKTVHSILRYCAEKFQIPLEELYKTIAWPLSRKFGHAYEAFKLSIIDETVWEGIEPPSKDVLDELKNYISKRLTPQAVKIRADVEVSCFSYEGIDAIKDALKSAEDMSTEQMQVKVKLVAAPLYVLTTQALDKQKGIEQLESAIEKITEVITKYGGVCNITMPPKAVTATEDAELQALLESKELDNRSDSEDDEDESDDE