wanglab/gogpt-training-data huggingface dataset:
Protein: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) (P04805)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00022}.
Interaction partners:
- Leucine--tRNA ligase
- Lysine--tRNA ligase
- Methionine--tRNA ligase
- Glutamyl-tRNA reductase
- Proline--tRNA ligase
- Isoleucine--tRNA ligase
- Arginine--tRNA ligase
- Lysine--tRNA ligase, heat inducible
- Asparagine--tRNA ligase
- Large ribosomal subunit protein uL13
Sequence:
MKIKTRFAPSPTGYLHVGGARTALYSWLFARNHGGEFVLRIEDTDLERSTPEAIEAIMDGMNWLSLEWDEGPYYQTKRFDRYNAVIDQMLEEGTAYKCYCSKERLEALREEQMAKGEKPRYDGRCRHSHEHHADDEPCVVRFANPQEGSVVFDDQIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVVDDWDMEITHVIRGEDHINNTPRQINILKALKAPVPVYAHVSMINGDDGKKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSHGDQEIFTREEMIKYFTLNAVSKSASAFNTDKLLWLNHHYINALPPEYVATHLQWHIEQENIDTRNGPQLADLVKLLGERCKTLKEMAQSCRYFYEDFAEFDADAAKKHLRPVARQPLEVVRDKLAAITDWTAENVHHAIQATADELEVGMGKVGMPLRVAVTGAGQSPALDVTVHAIGKTRSIERINKALDFIAERENQQ
Protein: Uncharacterized protein Rv2083 (P9WLK3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein Rv2084
- Uncharacterized protein Rv2082
Sequence:
MTSIESHPEQYWAAAGRPGPVPLALGPVHPGGPTLIDLLMALFGLSTNADLGGANADIEGDDTDRRAHAADAARKFSANEANAAEQMQGVGAQGMAQMASGIGGALSGALGGVMGPLTQLPQQAMQAGQGAMQPLMSAMQQAQGADGLAAVDGARLLDSIGGEPGLGSGAGGGDVGGGGAGGTTPTGYLGPPPVPTSSPPTTPAGAPTKSATMPPPGGASPASAHMGAAGMPMVPPGAMGARGEGSGQEKPVEKRLTAPAVPNGQPVKGRLTVPPSAPTTKPTDGKPVVRRRILLPEHKDFGRIAPDEKTDAGE
Protein: Calcium-channel protein CCH1 (P50077)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with MID1 to ensure that adequate levels of Ca(2+) are supplied to PMR1 to sustain secretion and growth. Required for growth in low-calcium environments.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10958666}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Stretch-activated cation channel MID1
- Protein ECM7
- Calcium-transporting ATPase 2
- Vacuolar calcium ion transporter
- Calmodulin
- Calcineurin subunit B
- Calcium-transporting ATPase 1
- Calcium channel YVC1
- Transcriptional regulator CRZ1
- Myosin light chain 2
Sequence:
MQGRKRTLTEPFEPNTNPFGDNAAVMTENVEDNSETDGNRLESKPQALVPPALNIVPPESSIHSTEEKKGDEYNGNDKDSSLISNIFRTRVGRSSHENLSRPKLSLKTASFGAAESSRRNVSPSTKSAKSSSQYIDLNDERLRRRSFSSYSRSSSRRVSNSPSSTDRPPRSAKVLSLIAADDMDDFEDLQKGFKSAIDEEGLTWLPQLKSEKSRPVSDVGEDRGEGEQESIPDVHTPNVGASATPGSIHLTPEPAQNGSVSEGLEGSINNSRKKPSPKFFHHLSPQKEDKDQTEVIEYAEDILDFETLQRKLESRPFVLYGHSLGVFSPTNPLRIKIARFLLHRRYSLLYNTLLTFYAILLAIRTYNPHNVVFLYRFSNWTDYFIFILSACFTGNDIAKIIAFGFWDDSEMFKAYGREYKSILQRSGIMKLYIYLREKYGRKLIDFIIPFRIISPGEETKYQRSSLSTSLTKPYGAKENQRPFGTPRAFARSSWNRIDLVSSVSFWLGMFLSIKSYDTKTGIRIFKPLAILRILRLVNVDTGMPSILRGLKYGIPQLVNVSSMLVYFWIFFGILGVQIFQGSFRRQCVWFNPEDPTDTYQYDMQFCGGYLDPVTKRKQNYIYEDGSEGSVSKGFLCPQYSKCVSNANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYYTMDSDEMAACLFFIVCIFVLTIWLLNLLIAVLVSSFEIANEEYKKKKFIYGSRKTGYVARIVTGYWKYFKLKANQTKFPNWSQKGLAIYSHVEFIFVILIICDIGMRASVKVSTSANCNNILLKTDRGISIVLFIESLARLVLYLPNMWKFLTKPSYVYDFIISIITLVISCLAVEGVLGHMYAWLSIFHISRFYRVIISFNLTKKLWKQILSNGVMIWNLSSFYFFFTFLVAIIMAVYFEGVIPPEEMADQPFGMYSLPNSFLSLFIIGSTENWTDILYALQKHSPNISSTFFCSVFFIIWFLLSNSVILNIFIALISESMEVKEEEKRPQQIKHYLKFVYPQKIQEYTHASLVARIRKKFFGGHRNEDTRDFKQFLMRGTAIMNIAQNMGELADEFKEPPSENLFKKGLSKLTIGVPSLKRLRMFANNPFYKNSDVVFTETNDINGRTYILELNEYEDEKLDYLKKYPLFNYSYYFFSPQHRFRRFCQRLVPPSTGKRTDGSRFFEDSTDLYNKRSYFHHIERDVFVFIFALATILLIVCSCYVTPLYRMHHKMGTWNWSSALDCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFIDFCVLISMWINLIAYLKNNGNLSRIFKGLTALRALRCLTISNTARQTFNLVMFDGLNKIFEAGLISLSLLFPFTVWGLSIFKGRLGTCNDGSLGRADCYNEYSNSVFQWDIMSPRVYQQPYLHLDSFASAFSSLYQIISLEGWVDLLENMMNSSGIGTPATVMGSAGNALFLVLFNFLSMVFILNLFVSFIVNNQARTTGSAYFTIEEKAWLESQKLLSQAKPKAIPNLIELSRVRQFFYQLAVEKKNFYYASFLQVVLYLHIIMLLSRSYNPGNLIGYQGVYFMFSTSVFLIQEALHMCGEGPRLYFRQKWNSIRLSIIIIAFIMNAVAFHVPASHYWFHNIKGFFLLVIFLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFLVYAIALNQIFGLTRLGSNTTDNINFRTVIKSMIVLFRCSFGEGWNYIMADLTVSEPYCSSDDNSTYTDCGSETYAYLLLMSWNIISMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSYLPRIMHSFDGPLSFKIWEGRLTIKSLVENYMEVNPDDPYDVKIDLIGLNKELNTIDKAKIIQRKLQYRRFVQSIHYTNAYNGCIRFSDLLLQIPLYTAYSARECLGIDQYVHHLYILGKVDKYLENQRNFDVLEMVVTRWKFHCRMKRTIEPEWDVKDPTVSSHISNINVNLEPAPGILEREPIATPRMDYGVNNFMWSPRMNQDSTMEPPEEPIDNNDDSANDLIDR
Protein: Neurogenic differentiation factor 4 (NeuroD4) (Helix-loop-helix protein xATH-3) (xATH3) (Protein atonal homolog 3) (P79920)
Organism: Xenopus laevis (African clawed frog)
Function: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MSEMVNVHGWMEEALSSQDEMKERNQSAYDIISGLCHEERGSIDGEEDDEEEEDGEKPKKRGPKKKKMTKARVERFRVRRVKANARERSRMHGLNDALENLRRVMPCYSKTQKLSKIETLRLARNYIWALSDILEQGQNAEGKGFLEILCKGLSQPTSNLVAGCLQLGPQAMFLDKHEEKSHICDSSLTGHTYNYQSPGLPSPPYGNIDVHHLHLKPSSFKPVMDPSVVTHTLNCTTPPYEGALTPPLSIGGNFSLKQDSSPDMDKSYAFRSPYPALGLGGSHGHASHFHTSVPRYELPIDMAYEPYPHHAIFTE
Protein: At5g46950 (Plant invertase/pectin methylesterase inhibitor superfamily protein) (Q9FJR6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Bnm1 like protein
- At4g00080
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- AT4g15750/dl3915c
- Probable pectinesterase 30
- MADS-box transcription factor PHERES 2
- Agamous-like MADS-box protein AGL28
Sequence:
MKFLVSLVIFSLFLNGFATAQTLIQDSCKKAFAKDPQSSYDFCVQSLTQDPQSKAATTLEDLALASTKNVAAKITNLKGIVAQDLKDQRYQDIVEDLKLCLGFYKDANDSLKTALANIKSRDYDGANSNLSAALNAPGDCEDDFKEAEKKSPITNENNILYKTIVIPLAFTTML
Protein: Beta-glucosidase 1A (EC 3.2.1.21) (Cellobiase 1A) (Q25BW5)
Organism: Phanerodontia chrysosporium (White-rot fungus) (Sporotrichum pruinosum)
Function: Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.
Interaction partners:
Sequence:
MSAAKLPKSFVWGYATAAYQIEGSPDKDGREPSIWDTFCKAPGKIADGSSGDVATDSYNRWREDVQLLKSYGVKAYRFSLSWSRIIPKGGRSDPVNGAGIKHYRTLIEELVKEGITPFVTLYHWDLPQALDDRYGGWLNKEEAIQDFTNYAKLCFESFGDLVQNWITFNEPWVISVMGYGNGIFAPGHVSNTEPWIVSHHIILAHAHAVKLYRDEFKEKQGGQIGITLDSHWLIPYDDTDASKEATLRAMEFKLGRFANPIYKGEYPPRIKKILGDRLPEFTPEEIELVKGSSDFFGLNTYTTHLVQDGGSDELAGFVKTGHTRADGTQLGTQSDMGWLQTYGPGFRWLLNYLWKAYDKPVYVTENGFPVKGENDLPVEQAVDDTDRQAYYRDYTEALLQAVTEDGADVRGYFGWSLLDNFEWAEGYKVRFGVTHVDYETQKRTPKKSAEFLSRWFKEHIEE
Protein: Pectate lyase A (EC 4.2.2.2) (Q9C2Z0)
Organism: Aspergillus niger
Function: Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MTNFKWIVAAAGLLFGQVLAAPTATSTHAKRATVSDAAFGYASLNGGTTGGAGGTTTTVSSYAAFTSAVSGDDAKVVYVDGTIKQTADQVKIGSNTSIIGKDANAILEGFGVLVKEKENVIIRNLGVSKVLADNGDAIGVQYSNNVWIDHCDVSSDRDHDKDYYDGLIDITHGSDYVTVSNTFIHDHWKASLVGHSDSNEDEDSGHLTVTYANNYWYNVNSRAPSFRFGTGHVYNSYYLDVSDGINTRDGAQLLVESNQFVDSKKALYSTDDGYAVSNDNDFGDSENTAEEGTLTSMPYDYTLLGSANVKAAVVGTAGQTLTF
Protein: Uncharacterized protein C22G7.03 (Q09797)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Zinc finger SWIM domain-containing protein sws1
- Uncharacterized protein C651.12c
- DNA repair protein rdl1
- DNA repair protein rlp1
Sequence:
MQQLIKEHFGNGGKVRSTSIEYPIFVHSGSISAMLLTLVNALECNDVDEGVLVYPTGSTNPMENILRMENPFDGFLAKEAYSIHFQSVLERIQLIPCSHVDDLEKIVEVRLKHAKLILGIADISKLLKIRGCLNGRYLSRYLMLCLQNSKILIVCETGGLQERIPIIEDISINEDTQRTVSLETIYATWIPTFWESKRKSHEKDEGRLVDRRHKVLVDWLANTCFRGMSLKDHSAL
Protein: At1g79720 (Eukaryotic aspartyl protease family protein) (Q8RX60)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Eukaryotic aspartyl protease family protein
- Phosphatidylinositol/phosphatidylcholine transfer protein SFH11
- Isovalerate--CoA ligase AAE2
- Serine/threonine-protein kinase PBL34
- Aspartic proteinase A3
- Aspartic proteinase A2
- Myrosinase-binding protein 1
- Probable cysteine protease RD21B
Sequence:
MFKKATLNLSLAPLLLVFLFLLSCVVHGVDEKKILSVHNNIWSPKKSYEASTSCFSRSLGKGRESTTLEMKHRELCSGKTIDLGKKMRRALVLDNIRVQSLQLKIKAMTSSTTEQSVSETQIPLTSGIKLESLNYIVTVELGGKNMSLIVDTGSDLTWVQCQPCRSCYNQQGPLYDPSVSSSYKTVFCNSSTCQDLVAATSNSGPCGGNNGVVKTPCEYVVSYGDGSYTRGDLASESILLGDTKLENFVFGCGRNNKGLFGGSSGLMGLGRSSVSLVSQTLKTFNGVFSYCLPSLEDGASGSLSFGNDSSVYTNSTSVSYTPLVQNPQLRSFYILNLTGASIGGVELKSSSFGRGILIDSGTVITRLPPSIYKAVKIEFLKQFSGFPTAPGYSILDTCFNLTSYEDISIPIIKMIFQGNAELEVDVTGVFYFVKPDASLVCLALASLSYENEVGIIGNYQQKNQRVIYDTTQERLGIVGENCRV
Protein: Sestrin-3 (EC 1.11.1.-) (P58005)
Organism: Homo sapiens (Human)
Function: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:25263562}.
Interaction partners:
- Sestrin-1
- Sestrin-2
- Voltage-dependent calcium channel subunit alpha-2/delta-2
- GATOR2 complex protein WDR24
- Cellular tumor antigen p53
- Rapamycin-insensitive companion of mTOR
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- 5'-AMP-activated protein kinase subunit gamma-2
- GATOR2 complex protein WDR59
- Peroxiredoxin-1
Sequence:
MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLANDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT
Protein: Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6) (Q9P2U8)
Organism: Homo sapiens (Human)
Function: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows the chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular H(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable). The symporter activity is driven by an inside negative membrane potential and is electrogenic (Probable). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:11698620}; Multi-pass membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q8BLE7}. Cell membrane {ECO:0000305|PubMed:33440152}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Vesicular inhibitory amino acid transporter
- Vesicular acetylcholine transporter
- Synaptic vesicular amine transporter
- Chromaffin granule amine transporter
- Vesicular glutamate transporter 1
- Vesicular glutamate transporter 3
- Glutamate decarboxylase 1
- Glutamate decarboxylase 2
- Excitatory amino acid transporter 2
- Disks large homolog 4
Sequence:
MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELTEDGKPLEVPERKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATTQANGGWPSGWEKKEEFVQGEVQDSHSYKDRVDYS
Protein: ABC transporter B family member 27 (ABC transporter ABCB.27) (AtABCB27) (Aluminum tolerance-related ATP-binding cassette transporter) (Antigen peptide transporter-like 2) (Transporter associated with antigen processing-like protein 2) (AtTAP2) (Q0WML0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably involved in redistribution of internalized aluminum. May mediate vacuolar sequestration of a metal complex.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:17151019, ECO:0000269|PubMed:17171374}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:17171374}.
Interaction partners:
- RNA-binding protein 48
- TRAF-like family protein
- Protein ALUMINUM SENSITIVE 3
- RBR-type E3 ubiquitin transferase
- P-loop nucleoside triphosphate hydrolase superfamily protein
- TIP41-like protein
- Defensin-like protein 90
- ABC transporter B family member 23, mitochondrial
- ABC transporter B family member 24, mitochondrial
Sequence:
MGNKKLLTGGSSKTHGSGSSYRDPLLQNQEDKPKANGSENGLNDLEHGVVEAANVGFGRVFALAKPDAGKLVIGTIALLIGSTTNLLVPKFGGMIIDIVSRDVKTPEQQTESLIAVRNAVVIILLIVVIGSICTALRAWLFNSASERVVARLRKDLFRHLMHQEIAFYDVTKTGELLSRLSEDTQIIKNAATTNLSEALRNVTTALIGVGFMFTSSWKLTLLALVVVPVISVAVKQFGRYLRELSHTTQAAAAVAASIAEESFGAVRTVRSFAKESYMVSQYSKKVDETLKLGLKQAVLVGLFFGGLNAAFTLSVITVVSYGAYLTIYGSMTVGALTSFILYSLTVGSSVSSLSSLYTTAMKAAGASRRVFQILDRVSSMSSSGDKCPVGNPDGDVELNDVWFAYPSRPSHMILKGISLRLTPGSKVALVGPSGGGKTTIANLIERFYDPLKGKILLNGVSLMEISHQYLHKQISIVSQEPILFNCSVEENIAYGFDGEASFTDIENAAKMANAHEFIEAFPDKYNTVVGERGLRLSGGQKQRIAIARALLTNPSVLLLDEATSALDAESEYLVQDAMDSLMAGRTVLVIAHRLSTVKTADCVAVISDGEVAEKGTHDELLSLNGIYTNLVKRQLQSSSSVTTL
Protein: Transcription initiation factor TFIID subunit 8 (TBP-associated factor 8) (AtTAF8) (Q9SYZ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 7
- Transcription initiation factor TFIID subunit 13
- Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 12b
- Transcription initiation factor TFIID subunit 4b
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 4
- Transcription initiation factor TFIID subunit 11b
Sequence:
MNTERAQEGDRNDAASSSGCSESYEFSHAAAKAAVAQVCESVGYENFKDPALESLSGFALQYILQLGKTATSFANLTGRSQCNVFDIILALDDLTDNNGEQGISSESCSLGRSIKLREIIDFVNSSEEVPFSQPLPSFPVAISDRSRKMIPSFVEIGETPPGKHIPLWLPAFPDPHTYKETPMWIERVSDPRGDKIEQARQRRKAERALLSLQRKLVCKISSRNPVWGDMDGVKEEMRDDESELRSVSSGEKVESLNRDGLSVIEAFAPAMEAARDGFSSEAHTEWKKNKPVALSKLRTEKKFLGQPLDLSLQMKGEDRPISFVREEDRDDKRRRAEFILRQCMENPVDLNQL
Protein: Mannosylglycoprotein endo-beta-mannosidase (AtEBM) (Endo-beta-mannosidase) (EC 3.2.1.152) [Cleaved into: Mannosylglycoprotein endo-beta-mannosidase 31 kDa subunit; Mannosylglycoprotein endo-beta-mannosidase 28 kDa subunit; Mannosylglycoprotein endo-beta-mannosidase 42 kDa subunit] (Q75W54)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glycosidase that specifically hydrolyzes the Man-beta-1,4-GlcNAc linkage in the trimannosyl core structure of N-glycans. Does not hydrolyzes pyridylamino derivatives sugar chains containing Man-alpha-1,3-Man-beta or Xylose-beta-1,2-Man-beta.
Interaction partners:
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- Xylose isomerase
- F3F19.21 protein family protein)
- DNA gyrase subunit B, mitochondrial
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2
Sequence:
MAEIGKTVLDFGWIAARSTEVDVNGVQLTTTNPPAISSESRWMEAAVPGTVLGTLVKNKAIPDPFYGLENEAITDIADSGRDYYTFWFFTKFQCQRLLNQYVHLNFRAINYSAQVFVNGHKTELPKGMFRRHTLDVTDILHPESNLLALIVHPPDHPGTIPPEGGQGGDHEIGKDVAAQYVQGWDWICPIRDRNTGIWDEVSISVTGPVRIIDPHLVSTFFDDYKRAYLHVTAELENKSTWNTECSVNIQITAELENGVCLVEHLQTENVLIPAQGRIQHTFKPLYFYKPELWWPNGMGKQNLYDILITVVVNEFGESDSWMQPFGFRKIESVIDSVTGGRLFKINGEPIFIRGGNWILSDGLLRLSKERYRTDIKFHADMNMNMIRCWGGGLAERPEFYHFCDIYGLLVWQEFWITGDVDGRGVPVSNPNGPLDHELFLLCARDTVKLLRNHPSLALWVGGNEQVPPKDINEALKQDLRLHSYFETQLLSDKDSDPSVYLDGTRVYIQGSMWDGFADGKGNFTDGPYEIQYPEDFFKDTYYKYGFNPEVGSVGMPVAETIRATMPPEGWTIPLFKKGLDGFIKEVPNRMWDYHKYIPYSNPGKVHDQILMYGTPENLDDFCLKAQLVNYIQYRALFEGWSSQMWTKYTGVLIWKNQNPWTGLRGQFYDHLLDQTASFYGCRSAAEPVHVQLNLASYFVEVVNTTSKELSDVAIEASVWDLDGNCPYYKVFKIVSAPPKKVVKISEFKYPKAANPKHVYFLLLKLYTVSDKAVISRNFYWLHLPGKNYTLLEPYRKKQIPLKITCNAVMVGSRYELEVNVHNTSRANLAKNVVQEDEKRDLGLLQKLFSRCVVSADSNRGLKVVEMKGSDSGVAFFLRFSVHNAETEKQDTRILPVHYSDNYFSLVPGESMSFKISFAAPTGMKKSPRVMLQGWNYPDRFSVFG
Protein: Guanidinoacetate N-methyltransferase (EC 2.1.1.2) (Q14353)
Organism: Homo sapiens (Human)
Function: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development.
Interaction partners:
- Glycine amidinotransferase, mitochondrial
- Creatine kinase U-type, mitochondrial
- Creatine kinase S-type, mitochondrial
- Creatine kinase M-type
- Sodium- and chloride-dependent creatine transporter 1
- Creatine kinase B-type
- Methyl-CpG-binding protein 2
- Ribosome biogenesis protein BRX1 homolog
- Ribosome production factor 2 homolog
- GTP-binding protein 4
Sequence:
MSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYMHALAAAASSKGGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQTHKVIPLKGLWEDVAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWGELMKSKYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMITPLVTKG
Protein: Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (Q2L6I0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00649}.
Interaction partners:
Sequence:
MGSGPIDPKELLKGLDSFLNRDGEVKSVDGISKIFSLMKEARKMVSRCTYLNILLQTRSPEILVKFIDVGGYKLLNNWLTYSKTTNNIPLLQQILLTLQHLPLTVDHLKQNNTAKLVKQLSKSSEDEELRKLASVLVSDWMAVIRSQSSTQPAEKDKKKRKDEGKSRTTLPERPLTEVKAETRAEEAPEKKREKPKSLRTTAPSHAKFRSTGLELETPSLVPVKKNASTVVVSDKYNLKPIPLKRQSNVAAPGDATPPAEKKYKPLNTTPNATKEIKVKIIPPQPMEGLGFLDALNSAPVPGIKIKKKKKVLSPTAAKPSPFEGKTSTEPSTAKPSSPEPAPPSEAMDADRPGTPVPPVEVPELMDTASLEPGALDAKPVESPGDPNQLTRKGRKRKSVTWPEEGKLREYFYFELDETERVNVNKIKDFGEAAKREILSDRHAFETARRLSHDNMEEKVPWVCPRPLVLPSPLVTPGSNSQERYIQAEREKGILQELFLNKESPHEPDPEPYEPIPPKLIPLDEECSMDETPYVETLEPGGSGGSPDGAGGSKLPPVLANLMGSMGAGKGPQGPGGGGINVQEILTSIMGSPNSHPSEELLKQPDYSDKIKQMLVPHGLLGPGPIANGFPPGGPGGPKGMQHFPPGPGGPMPGPHGGPGGPVGPRLLGPPPPPRGGDPFWDGPGDPMRGGPMRGGPGPGPGPYHRGRGGRGGNEPPPPPPPFRGARGGRSGGGPPNGRGGPGGGMVGGGGHRPHEGPGGGMGNSSGHRPHEGPGGGMGSGHRPHEGPGGSMGGGGGHRPHEGPGGGISGGSGHRPHEGPGGGMGAGGGHRPHEGPGGSMGGSGGHRPHEGPGHGGPHGHRPHDVPGHRGHDHRGPPPHEHRGHDGPGHGGGGHRGHDGGHSHGGDMSNRPVCRHFMMKGNCRYENNCAFYHPGVNGPPLP
Protein: GEO12066p1 (Growth-blocking peptide 1) (A1ZAQ9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH14572p
- GEO08278p1
- GEO10377p1
- Probable G-protein coupled receptor Mth-like 10
- Neuropeptide CCHamide-2
Sequence:
MLIRINPLVLCILPLVFLLTEARTRPSGNDRIVFPKDDDDTSSRFTYSTTTTTEEPASTIALRLESTNSTEQITSGSEELVNENTTVLPVIDNRILLETTQKCKPGFELFGKRCRKPA
Protein: Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (P06212)
Organism: Gallus gallus (Chicken)
Function: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
Subcellular location: Nucleus.
Interaction partners:
- Estrogen receptor beta
- Progesterone receptor
- Uncharacterized protein.
- E1A binding protein p300.
- Proto-oncogene tyrosine-protein kinase Src
- CREB binding protein.
- Nuclear receptor coactivator.
- Nuclear receptor interacting protein 1
- Transcription factor
- G-protein coupled estrogen receptor 1
Sequence:
MTMTLHTKASGVTLLHQIQGTELETLSRPQLKIPLERSLSDMYVESNKTGVFNYPEGATYDFGTTAPVYGSTTLSYAPTSESFGSSSLAGFHSLNNVPPSPVVFLQTAPQLSPFIHHHSQQVPYYLENEQGSFGMREAAPPAFYRPSSDNRRHSIRERMSSTNEKGSLSMESTKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGEMMKQKRQREEQDSRNGEASSTELRAPTLWTSPLVVKHNKKNSPALSLTAEQMVSALLEAEPPIVYSEYDPNRPFNEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATAARFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEERDYIHRVLDKITDTLIHLMAKSGLSLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPAARSAAPMEEENRNQLTTAPASSHSLQSFYINSKEEESMQNTI
Protein: mRNA decay activator protein ZFP36L3 (Zinc finger protein 36, C3H1 type-like 3) (zinc finger protein 36-like 3) (Q5ISE2)
Organism: Mus musculus (Mouse)
Function: Placenta-specific zinc-finger RNA-binding protein that destabilizes cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Binds to the 3'-UTR ARE of placental target mRNAs, such as TNF, HBEGF and LIPG. Involved in placental expression of many genes important for normal placental physiology.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15814898, ECO:0000269|PubMed:18367448, ECO:0000269|PubMed:26493225}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes exlusively in the cytoplasm (PubMed:15814898, PubMed:18367448). Not detected in the nucleus despite the presence of a nuclear localization signal (NLS) in the zinc finger regions; a C-terminal alanine-rich repeat domain is able to override the activity of the nuclear localization signal and prevent import into the nucleus (PubMed:18367448, PubMed:26493225). {ECO:0000269|PubMed:15814898, ECO:0000269|PubMed:18367448, ECO:0000269|PubMed:26493225}.
Interaction partners:
Sequence:
MANNNLNRPLNTNVADSSNSSSTPGTAPPPSSSDPQVLGHQAPSSSASSLTEDCSSSFARDLNSYNNGQSGATGAVSWEAPHEPSEANAVSQIHPRNGEHSLQQKPKPQKVSGSSSLATSERYKTELCRPFEESGICKYGHKCQFAHGYRELRTLSRHPKYKTEPCRTFHSVGFCPYGTRCHFIHNQPEQQPVLSESTLEEPSSFNGSNVLHLGVNGEQQPGLQSDSPSGFLSVNSQALQAPLQLNQQALSSGGVMPSSHPAAANLRMMCCRTSSSTTAHDADKDPDKDADKDPSNNSANDALAFPQEPGDFSPVAFQNPNTATTTPTAFYNNQQQMGLAASAQFQMPLARPLPSATIFGQASVGPALTPGAAMAPGAALAPAAALTPAAALAPGAAMALGAAMATGAAMATGAALTPGAALALGAAMAAGAALAPGAAMAPGAAMATGAALAFGAAMATGTTLTPGAAMALGAAMATGAALAPGAAVAPRAALAPRAAFAPGAAALAPRAALPPGAALTPGAALAPGAALAPRAALPPGATLRPGAALIPRAALAPGAALAPGAALTPGAALAPGATLAPRAALAPGAALAPRITITSRAAITPGVAIAPGVATASTGILAPGAATATVGNTSSTTITAATAAEGAAPHFTFQLPDVESESESESLEFDVVTSTLDSLLVSDDEDEDDFLRRSSSSSSLNESEFDNTNSSRRLPIFSRFSDSEK