wanglab/gogpt-training-data huggingface dataset:
Protein: N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (Q9I5D1)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein
- Beta-lactamase
- HTH-type transcriptional activator AmpR
- Uncharacterized protein
- Uncharacterized protein
- AmpG
- Beta-hexosaminidase
- Soluble lytic transglycosylase B
- Phage holin
- Probable zinc protease
Sequence:
MLTIDYNSYRTTTPYGKRVRFLVLHYTALDFAASVKALTTGAASAHYLIPAPHDPSYKAAGFKGQRIFNLVAEEDRAWHAGVSGWARRDNLNDTSIGIEIVNLARDDDGVFTFPDYERSQINALKQLAKNILQRYPDMTPKNVVGHSDIAVGRKSDPGPKLPWKELYEAGIGAWYDDATRDRYREGFERDGLPPRADLLEAFRLYGYALPATVDDAYFASLLRAFQMHFRPENYDGALDVETAAILYALNEKYPA
Protein: UDP-glucuronate:glycolipid 2-beta-glucuronosyltransferase (UDP-GlcA:glycolipid glucuronosyltransferase) (EC 2.4.1.264) (D-man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase) (Q8GCH2)
Organism: Xanthomonas campestris pv. campestris
Function: Catalyzes the transfer of a glucuronic acid (GlcA) residue from UDP-glucuronate to mannose-alpha-1,3-glucose-beta-1,4-glucose-P-P-polyisoprenyl to form the lipid-linked tetrasaccharide GlcA-Man-Glc(2)-PP-Pol, with a glucuronic acid-beta-mannose linkage. Is involved in the biosynthesis of the exopolysaccharide xanthan, since it catalyzes the fourth glycosylation step in the assembly of the pentasaccharide-P-P-polyisoprenyl repeating unit of xanthan. Is unable to use the trisaccharide acceptor freed from the pyrophosphate lipid moiety. Does not show specificity for the lipidic portion of the acceptor. Shows diminished activity when tested with 6-O-acetyl-mannose-alpha-1,3-glucose-beta-1,4-glucose-P-P-polyisoprenyl, a putative intermediate in the synthesis of xanthan; this could indicate that acetylation of the internal mannose takes place after the formation of the GumK product.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:14736729}; Peripheral membrane protein {ECO:0000269|PubMed:14736729}; Cytoplasmic side {ECO:0000269|PubMed:14736729}.
Interaction partners:
Sequence:
MSVSPAAPASGIRRPCYLVLSAHDFRTPRRANIHFITDQLALRGTTRFFSLRYSRLSRMKGDMRLPLDDTANTVVSHNGVDCYLWRTTVHPFNTRRSWLRPVEDAMFRWYAAHPPKQLLDWMRESDVIVFESGIAVAFIELAKRVNPAAKLVYRASDGLSTINVASYIEREFDRVAPTLDVIALVSPAMAAEVASRDNVFHVGHGVDHNLDQLGDPSPYAEGIHAVAVGSMLFDPEFFVVASKAFPQVTFHVIGSGMGRHPGYGDNVIVYGEMKHAQTIGYIKHARFGIAPYASEQVPVYLADSSMKLLQYDFFGLPAVCPNAVVGPYKSRFGYTPGNADSVIAAITQALEAPRVRYRQCLNWSDTTDRVLDPRAYPETRLYPHPPTAAPQLSSEAALSH
Protein: Protein ctg-1 (O17907)
Organism: Caenorhabditis elegans
Function: Vesicle trafficking protein (Probable). Functions in uterine cells to promote basement membrane (BM) mobility and BM gap formation during tissue remodeling.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:27661254}.
Interaction partners:
- 1-phosphatidylinositol 4-kinase
- Phosphatidylinositol 4-kinase beta
Sequence:
MLVSPTAAATSIEQQTIRDLRSIVPQIDNLNDGYVLRWLRAKEGRFDETAESLKKHVTFRNAWHLDKIEQWTPPECLEKYCGYGLLGDTEGRPILMSLLGNVDVEGLLRSVASLDYIKFSLAAIEKGMKLCEEKAKESGRPFEQMTLVFDLENITSAHFSCKQFASSFTTLVSLFQDHYPLFLRKILIIRAPEMARIAYASITAILQDPITRLVEMPSESDWKWSLAQIVNLDAWPMYWGGNLVENGDPKCPSRIKYGGGAVDESYFVDPKKAMADYDQLTTVYAGDKHLIQIKVKRPSRISWTYMTDEDDIGFEIHYDKTGSCDKLTEMETVYPYIRLECTNVPITGHLDVTDVGNYVLEFDNYYSWFSAKQLRYNIEIEDL
Protein: Augmin complex subunit dgt3 (Dim gamma-tubulin 3) (Q9W2P0)
Organism: Drosophila melanogaster (Fruit fly)
Function: As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules.
Subcellular location: Cytoplasm, cytoskeleton, spindle {ECO:0000305}.
Interaction partners:
- Augmin complex subunit dgt6
- Augmin complex subunit msd1
- Augmin complex subunit dgt2
- Augmin complex subunit dgt5
- Augmin complex subunit dgt4
- RNA-binding protein 42
- Augmin complex subunit msd5
- Augmin complex subunit wac
- Grip71
- LIM domain-containing protein jub
Sequence:
MGDLLSNSEFFKKLGVDSSNQWILYDEQMEMFFKFLSGNITDANILTERQVLEREEMQRRGEWLSASDRELKLLQIEAESPGLLNYKQQDVDALTMSIEAIEDASRDYATLLEDMMTTKHSITKHLGEVECVTAELQLREKDLIAECQSKAKQLEELQQENCRLSAEAKKAFTAPQLPPLFMHQLPLEQYFHKCDSFMQYFTLYVKENFKIQDYDEFQSAEEDLGREKAKLEDLERGIQFYALSYIRTKAKVKATQCLIDQLDLGKIHCLSLTDMAREMHDLQLLNDYQLSNTHDTLLNDLTIHIQQHTQRRIELVLYENTKLKLERAVRRHESDKKLTKIISDALSNAELLWIAIQLDCDKKRNCLDTSEELRDQAQATWQRIQTMRSINASYQGICAQFVQEIANLLSAHLGQNIKATEAKACLFEYEKFGRLLSYSFQSMLNRKSCAAVQDQLAELKRLEQTLRPFVYDSPLEQPMFENVRYLSAIYNVTQQQTRLDESGRSLRKDFLENVVGRIERDKLYRYSVVLWIWFLTEPQRMMHAIDEVKKAAAAVIRPGGGLHRK
Protein: Short stature homeobox protein 2 (Homeobox protein Og12X) (OG-12) (Paired family homeodomain protein Prx3) (P70390)
Organism: Mus musculus (Mouse)
Function: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. May also have a role in heart development.
Subcellular location: Nucleus.
Interaction partners:
- T-box transcription factor TBX18
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
- T-box transcription factor TBX3
Sequence:
MEELTAFVSKSFDQKVKEKKEAITYREVLESGPLRGAKEPGCVEPGRDDRSSPAVRAAGGGGGAGGGGGGGGGGGGGAGGGGAGGGAGGGRSPVRELDMGAAERSREPGSPRLTEVSPELKDRKDDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNVTPLSFQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMMFPAPPFGLPLATLAADSASAASVVAAAAAAKTTSKNSSIADLRLKAKKHAAALGL
Protein: ATP phosphoribosyltransferase 2, chloroplastic (ATP-PRTase 2) (AtATP-PRT2) (EC 2.4.2.17) (Q8GSJ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
- Histidine biosynthesis bifunctional protein hisIE, chloroplastic
- 1-
- Histidinol dehydrogenase, chloroplastic
- Imidazoleglycerol-phosphate dehydratase 1, chloroplastic
- Imidazole glycerol phosphate synthase hisHF, chloroplastic
- Histidinol-phosphate aminotransferase 1, chloroplastic
- Imidazoleglycerol-phosphate dehydratase 2, chloroplastic
- Helicase protein with RING/U-box domain-containing protein
- Ribose-phosphate pyrophosphokinase 1, chloroplastic
- Ribose-phosphate pyrophosphokinase 5, chloroplastic
Sequence:
MPISIPLNATLQYSSPSSSSSSSSLVPSSPLFSPIPSTTVSLTGIRQRCLRMVTSCVSNAQKSVLNGATDSVSVVGREQIRLGLPSKGRMAADSLDLLKDCQLFVKQVNPRQYVAQIPQLPNTEVWFQRPKDIVRKLLSGDLDLGIVGLDIVGEFGQGNEDLIIVHEALNFGDCHLSLAIPNYGIFENIKSLKELAQMPQWTEERPLRVATGFTYLGPKFMKDNGIKHVTFSTADGALEAAPAMGIADAILDLVSSGTTLKENNLKEIEGGVVLESQAALVASRRALTERKGALETVHEILERLEAHLKANGQFTVVANMRGTDAEEVAERVKTQPSLSGLQGPTISPVYCKRDGKVTIEYYAIVICVPKKALYESVQQLRAVGGSGVLVSPVTYIFHEETPRWSQLLSNLGL
Protein: Uncharacterized protein (F4J0L7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDINLIISIINLEVMGGGEEVVDMAVEHERVDSSGSSFHSGGGIAGSGTRPASSGIGWSKPAATATDGDIGNHTGEGVTRGSNGLNTSLASRVGAAEPMERAFHHVEKVATLRGEDFPSLKASLPSASVSGQKQKEGLNQKQKQAAGEDFSKEPRGVSGMSSSLVDMRPQNQSGRSRLGNELSESPSFSDGLHSSEHVRKKEYFAGPLPLVRLAPRSDWADDERDTSHGLRDRDRDHGYSKNEPFWDRGFDLRPHVLPQKHAASNVFDKPGQRENEIAKSSLTQVRPVSGGGREANAWRVSSPLQNEGANHNNYGARPSSRGREAAKKSNYVLSSSRENVWNNSGAREAPYQHGGRQPWNNNMDSSSNRGTYNRDGYGIEHQNRDKRSFFKSDKPHVEDPFMKDFGDSGFDVHDPFPVLGVTKKKKEALKQTEFHDPVRESFEAELERVQKMQEEERRRIIEEQERVIELARTEEEERLRLAREQDERQRRLEEEAREAAFRNEQERLEATRRAEELRKSKEEEKHRLFMEEERRKQAAKQKLLELEEKISRRQAEAAKGCSSSSTISEDKFLDIVKEKDSADVVDWEDSERMVDRITTSSTLDLSVPMRSFESNATSQFSRDGSFGFPDRQKPTWRKEDIESGSNSRFIPQNLENVPHSPQEEFFGTAGYLSAPSYFKPGFPEHSIDQSWRIPGDGRTHGRNYGMESESRENFGEQYGDPGWGQSQGRPRHGPYSPYPEKLYQNPEGDDYYPFGRPRYSVRQPRVLPPPQESRQKTSFRSEVEHPGPSTSIGGINYSHKGRTNSTVLANYIEDHHVLPGSGIDEHRRFDTKLTGRCDSQSSLSVTSPPDSPVHLSHDDLDESADSTVLPTSRMGEDAGLLEKGGAPIISSDIGKDSLMMATGSVSCWDNEEWTLDSNERLQEQEEYDEDEDGYQEEDKIHGVDENIDLAQELEEMHLDDKDSNLVLGFNEGVEVEIPSDDFEKCQRNSESTFPLHQHTVDSLDDERPSIETSRGEQAAQPAVVSDPLGMHNASRTFQGAETTMQNLTVHPNIGRQSFEVASKVDSTSNSTVSTHPVIPLHSAALHPSSLQTAIPPVSTTSAQMEEPVKFQFGLFSGPSLIPSPFPAIQIGSIQMPLPLHPQFGSSLTHMQQPQPPLIQFGQLPYTSPISQGVLPPPHHSVVQANGLSTYALNQNPGSLVTVQLGQGNSANLLARNAATSVSHPQLSVLRRPTNVSDEGTLKNANLPPARASIEAAVSPQKQPELSGNSQLPSRKMSHGKSNFAERQSGYQVQTDTSAVRNSGLRSSGTAEVSRVDSGGNRRYRRQRVEFRVRESNWPSSDENRNGNGRAQTSTKIGSRKYVVSNKSQKQALDSSASGLNAMQKTVSGGSFENRLGKDAVVKNPLSPNSGQANLKRNMVSEKEIDAPLQIGIVRVFEQQGIEAPSDDDDFIEVRSKRQMLNDRREQREKEIKEKSQAAKAFRKPRSTFQNNTTAARSNRSPPASRAANNKQFNPVSNRQTLAPIGTPSPKIDSHVDEKSGSNKSTQESSALPVIPKNDQNPASGFVFSNKNKVLDNSHTPVGTWGNQLTYQPVMALTQSQLDEAMKPVSHLSCVSVENGANRISESNSTSTSVVPKNNTFSSSTSPINSLLAEGKIQFGAVTSSTVIPPCGGRTEKDSSLYFEKDNKHRNPSSTGIEICEAEAEAAASAIAVAAITNDETSGNALSTGSVLPVETKIYGGTELDDGAASGTVGGQTSRSKAEESLIVSLPADLSVDTPISLWPQLPSPHNSNQMITHFPPGPPHYPFYDVNPMLRGPIFAFGPHHDAGATQSQSQKGPVTVSGPPTTWQQQGHSGVDSFYAPPAGFTGPFLTPPGAIPGVQGPPHMFVYNHFAPVGQFGGLSFMGTTYIPSGKQPDWKHNPNVSSSPVGGDGDVNNPNVASMQCNIVPASLQHLPMPMFDPSPFQSSSQEMPIRARWPYMPFSGPPTMQMQKQQEGTDGSNLPSPQFNNNMLPPPPPNRYPNVQASTVVDAMVDSSNAYSSTTGAPPAKPTSTLSDPNSNNTQNPNGPGFKPPQQQQQQSSQEKNTQSQHVGGPSHHHQHQHHQNRRSGYHGRNQPMARERGFPNNPKVKQIYVAKQTGNSCASASSTTTTTSPSI
Protein: Large ribosomal subunit protein uL2x (60S ribosomal protein L8-3) (Q42064)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL31x
- Large ribosomal subunit protein uL1x
- Large ribosomal subunit protein uL30y
- Large ribosomal subunit protein uL1z
- Large ribosomal subunit protein uL22z
- Large ribosomal subunit protein eL13z
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL24z
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein eL32z
Sequence:
MGRVIRAQRKGAGSVFKSHTHHRKGPAKFRSLDFGERNGYLKGVVTEIIHDPGRGAPLARVAFRHPFRFKKQKELFVAAEGMYTGQFLYCGKKATLVVGNVLPLRSIPEGAVICNVEHHVGDRGVFARASGDYAIVIAHNPDNDTSRIKLPSGSKKIVPSGCRAMIGQVAGGGRTEKPMLKAGNAYHKYRVKRNCWPKVRGVAMNPVEHPHGGGNHQHIGHASTVRRDAPPGKKVGLIAARRTGRLRGQAAALASKAD
Protein: G protein-coupled receptor kinase (EC 2.7.11.-) (F1RAR9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Arrestin, beta 2a.
- Arrb2b protein
- Beta-arrestin-1
- ARF GTPase-activating protein GIT1 isoform X2
- Chemokine
Sequence:
MEIETMAANCALLKARDAGNAYRKGRSRKWKEILHFPHINQCKELENSIERDYYSLCVNQPIGKQLFKLFCATEPKLQHLIDLLEEMAKYEVTTDDLKKTSRDKLINKFKTSQSSMVREMVHKEMQNGNLNMENFISSCHSALHEYLSGAPFSEYQNSMYFDRFLQWKMVERRPVTQDNFREYRILGKGGFGEVCACQSRASGKMYACKKLVKKRVKRQGGEKMVLKEKQILERVNSRFVVSLAYTYETKDSLCLVLTVMDGGDLGFHIYKMGNQKLDKNRVQFYAAEVLCGLDHLHKHNVVYRDLKPENILLDYEGHIRISDLGLAEILPENKLVKGRVGTAGYMAPEVVAGTSYGVSVDWWGLGCLIYEMTAKKPPFRNHKEQISKKDLEQRILEKVELYDKMFDEETQNICQKLLAKNPKERLGCRSGQGAEVIKSHQFFKNINFTLLEAGMMQPPFIPDPRAIYCDDVSDIDQFAAVKGVTLDEADEAFYAEFNTGSVTVPWQTEMIETECFKDLNVFGPHGTRSQDLDRSEQIQSTVSEFQSSSLKIQSPLSRSRLLGKIFRRAKDEPAEPILSKSSAGYEKL
Protein: CIZ1 protein (Q9BTG3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MFSQQQQQQLQQQQQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDQFAMPPATYDTAGLTMPTATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVQPQAHSQGPRQVQLQQEAEPLKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGGMEKTLPEPVGTQVSMEEIQNESACGLDVGECENRAREMPGVWGAGGSLKVTILQSSDSRAFSTVPLTPVPRPSDSVSSTPAATSTPSKQALQFFCYICKASCSSQQEFQDHMSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFVEHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVDFLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVTARPSQPPLPRRSTRLKT
Protein: Heat shock protein 26 (P02517)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Heat shock protein 23
- Heat shock protein 27
- Heat shock protein 67B3
- Heat shock protein 83
- Heat shock protein 68
- Major heat shock 70 kDa protein Aa
- DnaJ protein homolog 1
- Major heat shock 70 kDa protein Ba
- Heat shock 70 kDa protein cognate 2
- Heat shock factor protein
Sequence:
MSLSTLLSLVDELQEPRSPIYELGLGLHPHSRYVLPLGTQQRRSINGCPCASPICPSSPAGQVLALRREMANRNDIHWPATAHVGKDGFQVCMDVAQFKPSELNVKVVDDSILVEGKHEERQDDHGHIMRHFVRRYKVPDGYKAEQVVSQLSSDGVLTVSIPKPQAVEDKSKERIIQIQQVGPAHLNVKANESEVKGKENGAPNGKDK
Protein: Uncharacterized acyltransferase C1851.02 (EC 2.3.-.-) (Q9US20)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Lysophospholipid acyltransferase
- Probable diacylglycerol pyrophosphate phosphatase 1
- Putative phosphatidate cytidylyltransferase
- Uncharacterized acyltransferase C1718.04
- Putative lysophosphatidic acid:oleoyl-CoA acyltransferase
- Nuclear elongation and deformation protein 1
- CTP-dependent diacylglycerol kinase 1
- Phospholipase D1
- Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit
- Putative 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
Sequence:
MGFIKSTLLATVTVFVGLCGINRFFTLPKCIRYHFRYFACHTFLAISSAYGVIASVVARLCGYPVMGQYLTAKAYYGLASTILDFRFKIENEEILRKHKSAVLVVNHQSELDILAIGRTFGPNYSVIAKKSLRYVPILGWFMILSDVVFIDRSRRSDAIQLFAKAARRMRKENISIWVFAEGTRSYSLKPCLLPLKKGAFHLAVQAQVPIIPIAIQTYGHLFHPPTKVFNKGEALIKVLDPIPTEGKTAEDVNDLLHETETAMNNALVEIDDYGKVKKQ
Protein: Serine hydroxymethyltransferase (EC 2.1.2.1) (A0A8I6GI43)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
WLPFGQTLSCGQLVCMAARAQHSEVAQKQAGEAAGGWTGQESLSDSDPEIWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNNRKPSRALYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPQTGLIDYDQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKYADIVTTTTHKTLRGARSGLIFYRKGVRTVDPKTGQEIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLRNAQAMADALLKRGYSLVSGGTDTHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKRKTAKLQDFKSFLLKDPETSQRLANLRQQVEQFARGFPMPGFDER
Protein: Minor histocompatibility protein HMSD variant form (HSMD-v) [Cleaved into: Minor histocompatibility antigen ACC-6 (mHA ACC-6)] (P0C7T4)
Organism: Homo sapiens (Human)
Function: This splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. However, associated with GVHD, a favorable graft-versus-leukemia (GVL) can be induced by donor-recipient disparities in mHags. ACC-6 is presented to the cell surface by MHC HLA-B*4403. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. Immunogenicity of most autosomal mHags results from single-nucleotide polymorphisms that cause amino-acid substitutions within epitopes, leading to the differential recognition of peptides between donor and recipient.
Interaction partners:
Sequence:
MEIFIEVFSHFLLQLTELTLNMCLELPTGSLEKSLMISSQVLQIPVANSTKQR
Protein: Mitochondrial distribution and morphology protein 36 (Q06820)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in mitochondrial distribution and morphology.
Interaction partners:
- Nuclear migration protein NUM1
- Mitochondrial F-box protein MFB1
- Mitochondrial MYO2 receptor-related protein 1
- Dynamin-related protein DNM1
Sequence:
MDENGTVKPGYELKGLNSGNSRSNMDKDPIVSKFHRAGLNDSADEEDTDINGNRNTSWITSMISEEKRKVEGKSMLNDEEDLHLSKATLNKCDALVKILADIIKLEFVIHQSWYIRSLHKSVLIQFEVETSGGNKNSAGDSGDDDDDNHNGNLDDSFYKDLSLKCIKKCEKSSLALESLSRDIDQIRDFIMSNTIEDNRVDRLLQNSMTLLLECWIYSMKRLRRLRMKIAGIFVRSKLLLIDHELVTIWHFLQEQNEHETVNNENELKLAETIKSYRAFIKIFIQQLEDSESGSPSSSLFEECLHVFLDIESMYNSLNLNWLLNENKALQERLLSPSSTSENDHTNNLPVIDETKEIEDISSFVNSIVDASMLTHDLTPINSSDSDNLSNGEIDRLDGRRLSSSTSDMSLMMQRTSLQKQLPSLLTAFNNARRLEQELQNACKVNDNKHSTKDTDSNIRRNEHAMSSSVSSIISQNSTLASPSPPMSSSFISTAPSQSSSRMSTLPLSPSSSLLESQSQTLKNNMSQWLNQSRSGLNGTKLIPTNHIGFHSNVLNTLYGIGGGPVSKSYKSNQPSSQNT
Protein: Acidic leucine-rich nuclear phosphoprotein 32 family member E (Cerebellar postnatal development protein 1) (LANP-like protein) (LANP-L) (P97822)
Organism: Mus musculus (Mouse)
Function: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- E1A-binding protein p400
- Histone H2A.Z
- Histone acetyltransferase KAT5
- INO80 complex subunit C
- Transformation/transcription domain-associated protein
- Bromodomain-containing protein 8
- RuvB-like 1
- DNA methyltransferase 1-associated protein 1
- Iron-sulfur cluster assembly enzyme ISCU
- Vacuolar protein sorting-associated protein 72 homolog
Sequence:
MEMKKKINMELKNRAPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDDDEDGDEDEEDEDEDEAGPPEGYEEEEDDDEDEAGSEVGEGEEEVGLSYLMKDEIQDEEDDDDYVDEGEEEEEEEEEGLRGEKRKRDAEDDGEEDDD
Protein: Histone-lysine N-methyltransferase, H3 lysine-79 specific (Q679P5)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037123, ECO:0000256|RuleBase:RU271113}.
Interaction partners:
Sequence:
MKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTIEEQEAARRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAASAERKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTQLHSPNPLLVAPTPPALQKLLESFRIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFGHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEADAGRLRLELDCAKISLPHLSSMSPELSMNGHAASYELCNAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHPKESSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSEKGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSATLEKQTGASAHGAGGAGAGSRSLAVAPTGFYAGSVAISGALASSPAPLASGMESAVFDESSGPSSLFATMGSRSTPPQHPPLLSQSRNSGPASPAHQLTASPRLSVTTQGSLPDTSKGELPSDPAFSDPESEAKRRIVFSISVGASSKQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLSTGVSPKRRALPTVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGLTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGN
Protein: Palustrin-1b (P84275)
Organism: Lithobates palustris (Pickerel frog) (Rana palustris)
Function: Antimicrobial activity against Gram-negative bacterium E.coli.
Subcellular location: Secreted {ECO:0000269|PubMed:11087945}.
Interaction partners:
Sequence:
ALFSILRGLKKLGNMGQAFVNCKIYKKC
Protein: GEO09476p1 (Globin 1, isoform A (EC 1.11.1.-)) (Globin 1, isoform B) (Globin 1, isoform C) (Globin 1, isoform D) (Globin 1, isoform F) (RH41321p) (Q9VF15)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Globin 2
- Globin 3
- Uncharacterized protein, isoform D
Sequence:
MNSDEVQLIKKTWEIPVATPTDSGAAILTQFFNRFPSNLEKFPFRDVPLEELSGNARFRAHAGRIIRVFDESIQVLGQDGDLEKLDEIWTKIAVSHIPRTVSKESYNQLKGVILDVLTAACSLDESQAATWAKLVDHVYGIIFKAIDDDGNAK
Protein: Protein kti12 (Q9P7V4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Elongator complex-associated factor that is not a structural subunit but rather transiently contacts the complex. Required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Elongator complex protein 1
- Elongator complex protein 3
- Elongator complex protein 5
- Elongator complex protein 4
- Cytoplasmic tRNA 2-thiolation protein 1
- Elongator complex protein 2
- Adenylyltransferase and sulfurtransferase uba4
- Ubiquitin-related modifier 1
- Multifunctional methyltransferase subunit trm112
Sequence:
MPLIIVSGYPSSGKTTRSNELKKALEDRIHQNIDNTKDYRVIIINDESLNIEKETYRESKNEKAARGLLYSAVQRELSKSTFVICDALNYIKGFRYQLYCESKSMYTTHCVIHVAVPQDLCRKFNSNKEQPYPDDVLEQLMFRYEEPNGMTRWDSPLFTVLHDDASCPIDDIWSVLIHNKNVKPNQATMVKPPAEVNYLYELDKTTQDVIMLILDNSNDTSLITVPGSKLQIALPSVTVSLPLLQRLRRQFIQINRQQSYNTNVLKEMFVEFLNGQFETLD
Protein: Protein CLASP-2 (P32744)
Organism: Caenorhabditis elegans
Function: Probable microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the formation of mitotic and meiotic spindles. Specifically promotes the polymerization of kinetochore-bound microtubules. Also required for cytoplasmic streaming. Essential for embryonic development.
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localized to kinetochores during metaphase, and to the spindle region. Kinetochore localization requires hcp-1 and hcp-2.
Interaction partners:
- Kinesin-like protein klp-19
- Mitotic checkpoint serine/threonine-protein kinase bub-1
- HoloCentric chromosome binding Protein
- Kinesin-like protein
- Zygote defective protein 9
- Kinesin motor domain-containing protein
- Kinesin-like protein
- Meiotic spindle formation protein mei-1
Sequence:
MSRVISRSTPGGTCIVSKDDFLKSFEEVPKMEISSPSDFKEKLDQTIETLSKGQEDWNKRMNKLKQIRSMVVHGEDVIGREQLLSQLVRLTDCLDLSVKDLRSQILREAAITCGFLFKRFGTDVRQIAERCLPSAFAQVAVSTKVMATCGAVLTLFIVEFIQTKQIFTCIASYSTSKDKNQRRQLCALLEIVLEHWNEKIKRTVLPQIGELIKAAICDADPETRVAGRKAFSKLDALHSTEADKLFASVDSSKQKMLRASDAASSSTSINSERGTAPFRSKLSAGSIGGIRNAPNISSKFLAQRSASAIDTKQVTRMATSVSRTPNIRPMTTRTLSKIDTSPGGSKFARPTVGALGSRTSSNLRARGSVPTSQPGSRNGSPPRRPSATEAFPAEMQRVKSNLGSNSFVSSLSAEEATKLQKAMNTAKESLRQPSRNDDDEFLLPKRPTPQKATPQKSALDTSRVEEVIRACSSTSANEKREGIKMLAGIVSEPNLSNAEIKSLGAVLNRLLGESTNQIVLESISSFVKTHHPRLSDWLKLGLGKLFAKKGAEMTLNSKKQISTTISCILSSFDPTLQLKSTCELVCDPIHLMSPKSRVVLLEYLNELLGKYMERGSSFNTKEMKATILKMFSWMADQRNEQLITPHGEKVLCSLFALNNADFSALFNDFNPDYRDWAYKVLQSHGHDQHVPQQDAVSEEACVRATISTTAAQIEDFVVSRNLDMTPVKSPSTRAISSGFKRVDAEPLRPLSSEMNSQHRDEELSFNESFDRLKLNSTTHLIDDTSEQSKYVASKLAQISGDMGAQQYEGLLSIQTMLCEGSFTLWEQNFAKLLIAVFDVLSKSESDANKKVALRVLTKMCTSQASRLFDSTEMAICKVLDAAVNSQDGTMNVTADDCLKTLATHLPLAKVVNISQLILNEEKAQEPKASLVLKMMTRLFEGLQADELSPVVDDLAPCVIKSYDSPSSAVRKTAVYCLVAMVNKLGMKTMEPHLQNLSSGKLNLVQVYVNRAMSSSSHSHV
Protein: Uncharacterized protein (Q38A90)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGMHEGATEVFQALAVAPQERLESFLSLFTELCPAECALLALREQQQQQSSSKAATDMAGASFTAEDGDFAENVWRRFRERQDHNDANGTNSHISEAMEGELEVVELDESTACRTSSMTAFLEHGMTDVVPTVGVFVEGLQEELEKNREGKEMEGDPAEPAEESGTNILQEVNGEGSVGYGGVAFEGGPSSDSASDAVSVESQESSRSDISFGDINLPGISASGESKGEVPTPCPHVFLKADEVKGLEVDEDYVQPFALDPYFDYEATIVGKSVRLHPREFV