wanglab/gogpt-training-data huggingface dataset:
Protein: DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4) (P47928)
Organism: Homo sapiens (Human)
Function: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Oligodendrocyte transcription factor 1
- Oligodendrocyte transcription factor 2
- Transcription factor 4
- DNA-binding protein inhibitor ID-2
- Achaete-scute homolog 1
- Transcription factor E2-alpha
- Myogenin
- Transcription factor 12
- DNA-binding protein inhibitor ID-1
- E3 SUMO-protein ligase EGR2
Sequence:
MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAAAAAARCKAAEAAADEPALCLQCDMNDCYSRLRRLVPTIPPNKKVSKVEILQHVIDYILDLQLALETHPALLRQPPPPAPPHHPAGTCPAAPPRTPLTALNTDPAGAVNKQGDSILCR
Protein: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (Aggrecanase-1) (Q9ESP7)
Organism: Rattus norvegicus (Rat)
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Aggrecan core protein
- Brevican core protein
- Collagenase 3
- Stromelysin-1
- Collagen alpha-1
- Metalloproteinase inhibitor 1
- Metalloproteinase inhibitor 3
- Interleukin-1 beta
Sequence:
RRTKRFASLSRFVETLVVADDKMAAFHGAGLKHYLLTVMAAAAKAFKHPSIRNPVNLVVTRLVILGSGQEVPQVGPSAAQTLRSFCTWQKGLNPPNDSDPDHFDTAILFTRQDLCGVSTCDALGMAGVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCANLNGQGSSSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSSHCPQLPPPCAALWCFGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHVDQLKDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTKPVPRNGGKYCEGRRTPFRSCNTKNCPHGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPRDQCKLTCQARALGYYYVLEPRVADGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGNGSSCSKQSGSFKKFRYGYSDVVTIPAGRTHILVRQQGGSGLKSIYLALKLADGSYALNGEYTLMPSSTDVVLPGAVSLRYSGRTAASETLSGHGPLAQPLTLQVLVAGNPQNVRLRYSFFVPRPVPSTPRPPPQNWLQRRAEILEILRKRTWAGRK
Protein: Calmodulin-like protein 2 (Protein UNFERTILIZED EMBRYO SAC 14) (Q9SU00)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor that is required for pollen tube attraction for ovule fertilization.
Interaction partners:
- At2g03740
- GDSL esterase/lipase EXL6
- Plant intracellular Ras-group-related LRR protein 1
- Plant intracellular Ras-group-related LRR protein 9
- Embryo-specific protein 3
- Embryo-specific protein ATS3
Sequence:
MDRGELSRVFQMFDKNGDGKIAKNELKDFFKSVGIMVPENEINEMIAKMDVNGDGAMDIDEFGSLYQEMVEEKEEEEDMREAFRVFDQNGDGFITDEELRSVLASMGLKQGRTLEDCKKMISKVDVDGDGMVNFKEFKQMMRGGGFAALSSN
Protein: Methylglutaconyl-CoA hydratase, mitochondrial (3-MG-CoA hydratase) (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH) (Itaconyl-CoA hydratase) (EC 4.2.1.56) (Q9JLZ3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Can catalyze the reverse reaction but at a much lower rate in vitro. HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate. Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site) (By similarity). Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro. AREs direct rapid RNA degradation and mRNA deadenylation. Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, an antimicrobial metabolite and immunomodulator produced by macrophages during certain infections, that can act as a vitamin B12-poisoning metabolite (By similarity).
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10072761}.
Interaction partners:
- Hydroxymethylglutaryl-CoA lyase, mitochondrial
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
- Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- Isovaleryl-CoA dehydrogenase, mitochondrial
Sequence:
MAAAAPGALGALRTGRVRLVAACCARLGPAAWARGTAPRRGYSSEVKTEDELRVRHLEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRSVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLAFKEKRPPRYKGE
Protein: Homeobox protein Hox-C6 (Homeobox protein CP25) (Homeobox protein HHO.C8) (Homeobox protein Hox-3C) (P09630)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Interaction partners:
- Homeobox protein Hox-C9
- Homeobox protein Hox-C4
- Homeobox protein Hox-C5
- Homeobox protein Hox-B7
- Homeobox protein Hox-A7
- Homeobox protein Hox-B6
- Homeobox protein Hox-D4
- Homeobox protein Hox-A5
- Homeobox protein Hox-B5
- Homeobox protein Hox-B4
Sequence:
MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAVAQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE
Protein: Mannose-binding protein A (MBP-A) (Mannan-binding protein) (Ra-reactive factor polysaccharide-binding component p28B) (RaRF p28B) (P39039)
Organism: Mus musculus (Mouse)
Function: Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway (By similarity). Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:1637828, ECO:0000269|PubMed:25419660}.
Interaction partners:
- Mannan-binding lectin serine protease 2
- Plasma protease C1 inhibitor
- Mannan-binding lectin serine protease 1
- Complement C4-B
- Ficolin-2
- Anionic trypsin-2
- Mannose-binding protein C
- Complement C2
- Calreticulin
- Pentraxin-related protein PTX3
Sequence:
MLLLPLLPVLLCVVSVSSSGSQTCEDTLKTCSVIACGRDGRDGPKGEKGEPGQGLRGLQGPPGKLGPPGSVGSPGSPGPKGQKGDHGDNRAIEEKLANMEAEIRILKSKLQLTNKLHAFSMGKKSGKKLFVTNHEKMPFSKVKSLCTELQGTVAIPRNAEENKAIQEVATGIAFLGITDEATEGQFMYVTGGRLTYSNWKKDEPNNHGSGEDCVIILDNGLWNDISCQASFKAVCEFPA
Protein: Elongin BC and Polycomb repressive complex 2-associated protein (Embryonic stem cell-specific PRC2 subunit p48) (ES cell-specific PRC2 subunit p48) (esPRC2p48) (Q7TNS8)
Organism: Mus musculus (Mouse)
Function: Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation.
Subcellular location: Nucleus {ECO:0000269|PubMed:27863225}. Chromosome {ECO:0000269|PubMed:27863225, ECO:0000269|PubMed:27863226}. Note=Localizes at both PRC2/EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs) (PubMed:27863226). {ECO:0000269|PubMed:27863226}.
Interaction partners:
- Metal-response element-binding transcription factor 2
- PHD finger protein 19
- PHD finger protein 1
- Polycomb protein Suz12
- Zinc finger protein AEBP2
- Protein Jumonji
- Histone-lysine N-methyltransferase EZH1
Sequence:
METLCPPPRLAVPASPRGSPCSPTPLKPRRGTPEFSPLCLRALAFCALAKPRPSSLGLGPGELAPRTPVLLGPPASPCTGGWAADGLKHLGGQAGRPSDVSSPAREDADVAVCPGGGEEEEGGGGFPHFGAGSCAPPGRCPAPLRPQDSPTNPAWSPPRPARGLDAASSPPLEPGSPPPSPPAGLSPEPAPSEQPVPASEAPGGGDPAPTAPEAPALSPSTADAAPDPPRDLRQEHFNRLIRRSKLWCYAKGFALDTPSLRRGPERPAAKARGAAKKRRRPAPPPPSVQPRRPVPTLPTSSTFSLLDCFPCPPALVVEENGDLGPASSLRLQGDAKPPPAHPLWKWQMGGPAVPEPPGLKSWWVNLEEL
Protein: Pentatricopeptide repeat-containing protein At4g02750 (Q9SY02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cysteine/Histidine-rich C1 domain family protein
- Pentatricopeptide repeat-containing protein At1g02370
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- Pentatricopeptide repeat-containing protein At1g06270
- Nuclear pore complex protein NUP155
Sequence:
MEINKFRALSRRAQQLHYTSLNGLKRRCNNAHGAANFHSLKRATQTQIQKSQTKPLLKCGDSDIKEWNVAISSYMRTGRCNEALRVFKRMPRWSSVSYNGMISGYLRNGEFELARKLFDEMPERDLVSWNVMIKGYVRNRNLGKARELFEIMPERDVCSWNTMLSGYAQNGCVDDARSVFDRMPEKNDVSWNALLSAYVQNSKMEEACMLFKSRENWALVSWNCLLGGFVKKKKIVEARQFFDSMNVRDVVSWNTIITGYAQSGKIDEARQLFDESPVQDVFTWTAMVSGYIQNRMVEEARELFDKMPERNEVSWNAMLAGYVQGERMEMAKELFDVMPCRNVSTWNTMITGYAQCGKISEAKNLFDKMPKRDPVSWAAMIAGYSQSGHSFEALRLFVQMEREGGRLNRSSFSSALSTCADVVALELGKQLHGRLVKGGYETGCFVGNALLLMYCKCGSIEEANDLFKEMAGKDIVSWNTMIAGYSRHGFGEVALRFFESMKREGLKPDDATMVAVLSACSHTGLVDKGRQYFYTMTQDYGVMPNSQHYACMVDLLGRAGLLEDAHNLMKNMPFEPDAAIWGTLLGASRVHGNTELAETAADKIFAMEPENSGMYVLLSNLYASSGRWGDVGKLRVRMRDKGVKKVPGYSWIEIQNKTHTFSVGDEFHPEKDEIFAFLEELDLRMKKAGYVSKTSVVLHDVEEEEKERMVRYHSERLAVAYGIMRVSSGRPIRVIKNLRVCEDCHNAIKYMARITGRLIILRDNNRFHHFKDGSCSCGDYW
Protein: Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) (Q08602)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta
- Rab proteins geranylgeranyltransferase component A 1
- RAB22A, member RAS oncogene family
- Similar to RAB32
- Ras-related protein Rab-31
- RAB39A, member RAS oncogene family
- Ras-related protein Rab
- small monomeric GTPase
- Ras-related protein Rab-34
- GTP-binding protein Rab-3D
Sequence:
MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQHLETEKSPEESAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCVHVSREEACLSVCFSRPLTVGSRMGTLLLMVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTGSDSQKECVLLKDRPECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSILT
Protein: Protein unc-119 (Uncoordinated protein 119) (Q10658)
Organism: Caenorhabditis elegans
Function: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system.
Interaction partners:
- ADP-ribosylation factor-like protein 3
- ADP-ribosylation factor-like protein 2
- ADP-ribosylation factor-like protein 13B
- Protein XRP2
- Pharynx and intestine in excess protein 1
- Cuticle collagen rol-6
- Myosin-4
- Tubulin beta-2 chain
- Probable histone H2B 4
- Myosin-3
Sequence:
MKAEQQQQSIAPGSATFPSQMPRPPPVTEQAITTEAELLAKNQITPNDVLALPGITQGFLCSPSANVYNIEFTKFQIRDLDTEHVLFEIAKPENETEENLQAQAESARYVRYRFAPNFLKLKTVGATVEFKVGDVPITHFRMIERHFFKDRLLKCFDFEFGFCMPNSRNNCEHIYEFPQLSQQLMDDMINNPNETRSDSFYFVENKLVMHNKADYSYDA
Protein: RAB11 family interacting protein 3 (X6RFI8)
Organism: Homo sapiens (Human)
Subcellular location: Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}. Midbody {ECO:0000256|ARBA:ARBA00004214}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004654}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004654}.
Interaction partners:
Sequence:
WTEEPEECGPASCPESAPFRLQGSSSSHRARGEVDVFSPFPAPTAGELALEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGPRLRAVFDALDGDGDGFVRIEDFIQFATVYGAEQVKDLTKYLDPSGLGVISFEDFYQGITAIRNGDPDGQCYGGVASAQDEEPLACPDEFDDFVTYEANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLDAMEEPDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDPAFLTPSTDPLAAKLHSILTDEAFEFYCSQCHKQINRLEDLSARLSDLEMNSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK
Protein: Uncharacterized protein YNL144C (P53907)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- RNA polymerase II degradation factor 1
- Uncharacterized protein YKR045C
- Altered inheritance of mitochondria protein 41
Sequence:
MSSSIFEMTIDHDGMDSTGLKLSQTASSISMGDEFLCSSTTSNSILDSPLPKVTFNHIDSITDINTNIMNEIVEPQSGVDVDVADKNVLYCIDPYPVEPPCYDFANPSKVIRYPIYEHCRPCLTSVKPPSYTPSVEHYTVVSMKMEKLSPFENASSRLWNNFILQINSTQINFYSIDDSLTRHIKNYRGGDMFDHSHHSKTASDRHHSARSLLNAFTTKSTYQFDKYDKERICGEIARDEHKFLSDERLFKSYSLQCAKVGLPIDYSSRDFVLRMRCEGQQFLVQFSHVDELIYWAMYLNMGISLSLDLELREMPTYRSVPRRRHPRARRFKQHNKNKNKNKSRQNSDRNDSRSHSLLLRRSHTSSVVTKVATGNERPTNKSRSRSLSLLPPSVSDASHDSNGPNDSGSLAGESSQTDFCGLFTSKLRNFFKTDSSSRKNSNMDIGQKMRSKELNSVQEEIDDNGSTTNTNTSVLSSTFSPTAHSVLTAQTSIHENFRSRSNSNPIDPLRCDRSVLKINNFEPVYEGTGRSTISNSAERTNREEKLNRGNEDVNGDEDDDEDEDDANYEEDDEDGYVEDDDINRLVYLDERESRYENADVEYGTIFSTKSFSVTGCLNHDFPKKLSLKCGNKNQSSNDSKWAPATQLVSRKRYIKDSLRCIKPLTEDHPWVGKIIFKPALPPAFETNNPPIRVYSGEDSTDLMHVKNHYLKPYIVGSCGFLKTGSKLFHFYDRTNDLTNL
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (CI-B14) (NADH-ubiquinone oxidoreductase B14 subunit) (Q02366)
Organism: Bos taurus (Bovine)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:10852722, ECO:0000305|PubMed:18721790}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Interaction partners:
- NADH dehydrogenase 1 alpha subcomplex subunit 7
- Acyl carrier protein, mitochondrial
- NADH dehydrogenase 1 subunit C2
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH-ubiquinone oxidoreductase chain 5
- NADH dehydrogenase 1 beta subcomplex subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH-ubiquinone oxidoreductase chain 2
- NADH dehydrogenase iron-sulfur protein 5
Sequence:
MAASGLRQAAVAASTSVKPIFSRDMNEAKRRVRELYRAWYREVPNTVHLFQLDISVKQGRDKVREMFKKNAHITDPRVVDLLVIKGKMELEETIKVWKQRTHVMRFFHETEAPRPKDFLSKFYVGHDP
Protein: SH3 domain-containing protein (Q09989)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MAADVLAPGFWEVGSYKHNVKRFKDGVEQLDDYCKMSRERAEIEAKYSKMLSQHAEKWRAHVDRTVSAGSVKTVWNELIGEATALSRVHNSLKDCLIDDIVNETTTYRKNSLHTSVFKGPKEIREIEDHFEKAQKPWKKLVDKMEDKRGKYYNVCRQEKSALVNLQNCQTDTSVSPDAATKFRERHEKLKEEVQRTKVDYQKTLTNLNEYKNVYMEAMAHVFKMCQEKEMDRSQFLIGIVQKTQRHYANIIRNSQMSGLHQQLEQSIRSADSEAVKRDLAQWSSVNGVDAFSEWPSFVEYSPEIRNIAARGGSTKDAGGVILTRQINRSEDIPSTHSNTLPSVAVNTASSHEDVGKSSPKSSSESDTSTFDSRKHNSTANKYKNQPQNTTQIQPPPVGWHPSDGPDSPPLSTETPDSAKYGDFEEFTTSKPAVVLYDYAPAEGDEIALRKGEMIEVLTEPDSLGWCTGRVSGNVGLFPASYVQCQGEKS
Protein: Sensor histidine kinase HprS (EC 2.7.13.3) (Hydrogen peroxide response sensor) (P76339)
Organism: Escherichia coli (strain K12)
Function: Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Senses H(2)O(2), maybe via the redox state of the membrane. Activates HprR by phosphorylation. Can also phosphorylate CusR.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Transcriptional regulatory protein HprR
- Transcriptional regulatory protein CusR
- Sensor protein TorS
- Transcriptional regulatory protein CreB
- Phosphocarrier protein HPr
- Transcriptional regulatory protein BaeR
- Transcriptional regulatory protein CpxR
- Transcriptional regulatory protein BasR
- Transcriptional regulatory protein QseB
- TorCAD operon transcriptional regulatory protein TorR
Sequence:
MKRLSITVRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDTLPVYFNRMMDVSQDILIIHGDSINKIVNRTNVSDGMLNNIPASETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSIIICIVAIVLCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSYLNIDIASPGTKINEPEKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHYLNKHNVFRITLPQRN
Protein: Growth/differentiation factor 9 (GDF-9) (O60383)
Organism: Homo sapiens (Human)
Function: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Bone morphogenetic protein receptor type-2
- Bone morphogenetic protein 15
- Zygote arrest protein 1
- Homeobox protein NOBOX
- Follicle-stimulating hormone receptor
- Ret finger protein-like 4A
- Bone morphogenetic protein receptor type-1B
- TGF-beta receptor type-1
- Factor in the germline alpha
- Follistatin
Sequence:
MARPNKFLLWFCCFAWLCFPISLGSQASGGEAQIAASAELESGAMPWSLLQHIDERDRAGLLPALFKVLSVGRGGSPRLQPDSRALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPCTRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMIKEPKSSSRTLGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR
Protein: Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) (P32241)
Organism: Homo sapiens (Human)
Function: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8179610}; Multi-pass membrane protein {ECO:0000269|PubMed:36385145}.
Interaction partners:
- Pituitary adenylate cyclase-activating polypeptide
- VIP peptides
- Autophagy protein 5
- Guanine nucleotide-binding protein G
- Vasoactive intestinal polypeptide receptor 2
- Guanine nucleotide-binding protein G
- Receptor activity-modifying protein 2
- Actin nucleation-promoting factor WASL
- Guanine nucleotide-binding protein G
- Secretin
Sequence:
MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
Protein: Guanine nucleotide-binding protein subunit gamma 1 (Ggamma-subunit 1) (Heterotrimeric G protein gamma-subunit 1) (AtAGG1) (Q9FDX9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the abscisic acid (ABA) and ethylene signaling pathways. Regulates acropetal transport of auxin (IAA) in roots and hypocotyls, and thus modulates root architecture (e.g. lateral root formation). The heterotrimeric G-protein controls defense responses to necrotrophic and vascular fungi probably by modulating cell wall-related genes expression; involved in resistance to fungal pathogens such as Alternaria brassicicola, Plectosphaerella cucumerina and Fusarium oxysporum.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17158913, ECO:0000269|PubMed:17220359, ECO:0000269|PubMed:17644812}. Golgi apparatus membrane {ECO:0000269|PubMed:17158913, ECO:0000269|PubMed:17220359}. Golgi apparatus, trans-Golgi network membrane. Cytoplasm. Note=Localized to the cell membrane when attached to beta subunit GB1 (Probable) (PubMed:17158913). Present in the cytoplasm when associated with NUDT7 (PubMed:22068106). {ECO:0000269|PubMed:17158913, ECO:0000269|PubMed:22068106, ECO:0000305|PubMed:22068106}.
Interaction partners:
- Guanine nucleotide-binding protein subunit beta
- Guanine nucleotide-binding protein alpha-1 subunit
- Extra-large guanine nucleotide-binding protein 2
- Extra-large guanine nucleotide-binding protein 3
- Guanine nucleotide-binding protein subunit gamma 2
- Extra-large guanine nucleotide-binding protein 1
- Guanine nucleotide-binding protein subunit gamma 3
- Chitin elicitor receptor kinase 1
- Regulator of G-protein signaling 1
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
Sequence:
MREETVVYEQEESVSHGGGKHRILAELARVEQEVAFLEKELKEVENTDIVSTVCEELLSVIEKGPDPLLPLTNGPLNLGWDRWFEGPNGGEGCRCLIL
Protein: Drongo, isoform F (E1JHR0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Vesicle-associated membrane protein 7
Sequence:
MAVVRKKQDDKYLLALRELVASGTGSNRQCFDCGQKGPTYVNMTIGSFVCTRCSGVLRGLTPPHRVKSISMATFTQDEIDFLRSHGNELCAKTWLGLWDPKRAVHQQEQRELMMDKYERKRYYLEPASPLKSLANAVNLKSSAPATNHTQNGHQNGYASIHLTPPAAQRTSANGLQKVANSSSNSSGKTSSSISRPHYNHQNNSQNNNHDAFGLGGGLSSLNSAGSTSTGALSDTSSCASNGFGADCDFVADFGSANIFDATSARSTGSPAVSSVSSVGSSNGYAKVQPIRAAHLQQQQQLQQQLHQQQLLNGNGHQGTENFADFDHAPIYNAVAPPTFNDWISDWSRRGFHDPFDDCDDSPPGARPPAPAPAPAQVPAVSSPLPTVREEPELAWNFWEDEMRIEAQEKESQTKQPELGYSFSISTTTPLSPSNPFLPYLVSEEQHRNHPEKPSFSYSLFSSISNSSQEDQADDHEMNVLNANFHDFFTWSAPLQNGHTTSPPKGGNAAMAPSEDRYAALKDLDEQLRELKASESATETPTPTSGNVQATDAFGGALNNNPNPFKGQQQQQLSSHVVNPFQQQQQQQHQQNLYGQLTLIPNAYGSSSQQQMGHHLLQQQQQQQQSFFNFNNNGFAISQGLPNGCGFGSMQPAPVMANNPFAASGAMNTNNPFL