wanglab/gogpt-training-data huggingface dataset:
Protein: LD31537p (Q960X2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSASVICVDLSSESDEESPAKRRRLEDPLRLLTPSGRQSFPAKLLNIPKASLGSAMVVPVAETGPARETPVIVDPLRSMHIPSGITITKHQKNVLATNGNMNLSLAESNNNNNTTSLNKNVTPKQINVGTGQKVAWSVSSKAPSPNAVITTVPSHQVRVTPFNPIRLAPGSKIIPASNAMPAKIQPILGMGQPQQQAQAQQPKAIIVGFPKPNTAVAQMAQHQKPLTLQIHQKLIAGQQQHIASISQLQQVSLQQQQPLRPVSIQLQQQQNQRNGSLPGKQQKPLECPVPAQQEKLPRGPLPTKPAEPLSGPLPTEPDEPLGGPLPTRPKPPVRSLQQPVNKNTAIGVQIQQSQEPLGGTLPTRQKPLGGQLLTQQKPPVGSIQQSVKQNTGIGVQIQQIPKVVVGQQPQKVYLNKLQQEQQKIFLGHLQQQQQKTFLGQLQQEQQKILGQLQQQKQQQQQQQKKILGQSQQQKVPLGQPQPQQKLPQQLNNSLVQLQQQHHKMPTVTTFREGSLLKH
Protein: Protein TonB (Q51368)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
Subcellular location: Cell inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
Interaction partners:
- Biopolymer transport protein ExbD
- Transport protein ExbB
- Metal-pseudopaline receptor CntO
- Transport protein ExbD
- Metal-pseudopaline receptor CntO
- Tol-Pal system protein TolQ
- Transport protein ExbB2
- Translation initiation factor IF-2
- DNA-directed RNA polymerase subunit beta
- Glyceraldehyde-3-phosphate dehydrogenase
Sequence:
MSPQPSRSPDRFSLAALAEDHPTAPAQGDESESLPCVNAQRGEPNLRVVDCSGARRDEEVAVEEVLIPYAHGSDPEDVPGEPPKSRWWLSSGAAVAMHVAIIGALVWVMPTPAELNLGHGELPKTMQVNFVQLEKKAEPTPQPPAAAPEPTPPKIEEPKPEPPKPKPVEKPKPKPKPKPKPVENAIPKAKPKPEPKPKPEPEPSTEASSQPSPSSAAPPPAPTVGQSTPGAQTAPSGSQGPAGLPSGSLNDSDIKPLRMDPPVYPRMAQARGIEGRVKVLFTITSDGRIDDIQVLESVPSRMFDREVRQAMAKWRFEPRVSGGKIVARQATKMFFFKIEKRR
Protein: Sulfite reductase (NADPH) subunit beta (A0A1D8PHL8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- assimilatory sulfite reductase
- phosphoadenylyl-sulfate reductase
- Adenylyl-sulfate kinase
- Sulfurtransferase
- Sulfate adenylyltransferase
- Cysteine synthase 1
- Cysteine synthase
- Homocysteine/cysteine synthase
- Uroporphyrinogen-III C-methyltransferase
- cystathionine gamma-synthase
Sequence:
MSLRQEEAIAKVVKNIGGTVFVTQPAKSVESTFTNLFSEKITLLNSNEPYSSVQQYVSQSNDVDNEDAETEVVTVTTDGVTLLKNLPSFSSEVFQTNKIVSHIELNNFDYAIVTALRDLQYPVLVSQTSQEAYTYANLAYNLATKLNTSVFHFFAPTDYQSKKSIKLSEGVLLEKLENLSLDSIVSKFNVKPFEVVNKASSQKDAVLFLGQLNDELVNAANKENALLINIKIYKPFQLQHLLNIIPSSVQTISIVQQSTTPIVTFAPLLLDFFSEYSKYQALKNFTKIVSATFGFVTDYTAAISQLLANTRSDNPKQNLSFGKVNTVLATKSSKKKYEDYLEAVSEAHNLEQAYLKVLQQINSTNLKVLNEFQAANAGLEVNPEFGFGSFLFDQEQQENLVSLVQKSIKENSFHSVDNGKLIELLSQWLVQIQDSGEVENRLPVEIVDLLKTDETTTTARELLALSRHFTTEKNWLIGSDAWSYDLGSSGVHNVITSGKNINMLIIDSEPYSEKSSDKAINGSRKKDVGLYAMNYGDCYVASVAIYSSYTQVLQAFIEAEKFNGPSIVLAYLPYNSELDNTLTVLQETKKAVDSGYWPLYRYNPRVQNEADAFKLDSSNLRKQLSDFLERENKLTLLASKDPLLSRNLTANANTEAKTKQSKIADESFAQLLQGLSGPPLTVAFASDGGNAEAVAKKVNRQALGRGLKSVVLQMDDLSVEDLPTETNVVFITSTSGQGEFPTNGKQFWDGVKNTTDLDLSGIRFSVFGLGDSQYWPRKEDKHYYNKPAKDLFAKLKLYGGVELADIGLGDDQDADGFSTGFNEWIPKIWAALGVDNVEGVEEPKPITNEDMKIGSDYLRGTIVEGLNDQSTGAISAVDQQLTKFHGIYMQDDRDIRDERKAQGLEPAYTFMVRVRLPGGIATPDQYLKMDELADERGNGTLKLTTRATFQLHGVVKHDLKPAIRGMNSALMDTLAACGDVNRNVMVSALPHNAKVHGQVSQIGALISEFLLPKTTAYHEIWLQGDDAGDKPGYREAWENRKEGPTKKKTLVAGNVLADVEPQYGVTYLPRKFKIVITVPPYNDVDVYAHDVGLIAIVEDNEVVGFNVLAGGGMGSTHNNKKTYPRTGSMLGYVSKDQVHIACEKIMLVQRDFGDRTNRKHARLKYTIDDLGVDVFKAKVEELLGYKFDEPRPFKIESNIDYFGWCKDELGYNHFTAFIENGRIENTPELPQKTGLRKIAEFLKSGNRSGEFRLTGNQHILISNVSDQDLDEVKKLLAQYKLDNTDFSALRKSSAACVAFPTCGLAMAESERYLPVLITKLEEALEEYGLRHDSIVMRMTGCPNGCARPWVAEVALVGKAYGAYNLMLGGGHHGQRLNKIYRYSIKEDEILDILKPLFKRWSLERNENEPFGDWCIRAGIIAETTEGKYFHDDIPEDA
Protein: Trace amine-associated receptor 7f (TaR-7f) (Trace amine receptor 7f) (mTaar7f) (Q5QD08)
Organism: Mus musculus (Mouse)
Function: Olfactory receptor activated by trace amine N-methylpiperidine. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q923X5}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSIADETVSWNQDSILSRDLFSATSAELCYENLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGVMVMPFSMVRSVEGCWYFGDSYCKLHTCFDVSFCYCSLFHLCFISVDRYIAVSDPLAYPTRFTASVSGKCITFSWLLSISYGFSLIYTGASEAGLEDLVSSLTCVGGCQIAVNQTWVFINFSVFLIPTLVMITVYSKIFLIAKQQAQNIEKMSKQTARASDSYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSFIDAFLGFITPTYVYEILVWIVYYNSAMNPLIYAFFYPWFRKAIKLTVTGKILRENSSTTNLFSE
Protein: Precursor of CEP15 (PCEP15) [Cleaved into: C-terminally encoded peptide 15 (CEP15)] (O22882)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Extracellular signaling peptide that may regulate primary root growth rate and systemic nitrogen (N)-demand signaling.
Subcellular location: [C-terminally encoded peptide 15]: Secreted, extracellular space, apoplast {ECO:0000250|UniProtKB:O80460}. Note=Accumulates in xylem sap. {ECO:0000250|UniProtKB:O80460}.
Interaction partners:
- Precursor of CEP4
- Precursor of CEP13
- Precursor of CEP7
- Precursor of CEP8
- Precursor of CEP6
- Precursor of CEP14
- Protein IDA-LIKE 5
- Precursor of CEP11
- Precursor of CEP9
- Protein IDA-LIKE 4
Sequence:
MDATKIKFDVILLSFLLIISGIPSNLGLSTSVRGTTRSEPEAFHGGKFPAMKMRKLMAPNMEVDYSSDYYDGGSSSSTTSPSPPVPDYDDIYRRQGDVPSPGIGH
Protein: Epidermal growth factor receptor substrate 15-like 1 (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs) (Eps15-related protein) (Eps15R) (Q60902)
Organism: Mus musculus (Mouse)
Function: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:9446614}; Peripheral membrane protein {ECO:0000269|PubMed:9446614}. Nucleus {ECO:0000269|PubMed:9446614}. Membrane, coated pit {ECO:0000269|PubMed:9446614}. Note=Localized to plasma membrane coated pits.
Interaction partners:
- Epsin-1
- Epidermal growth factor receptor substrate 15
- Intersectin-2
- Epsin-3
- AP-2 complex subunit alpha-1
- Disabled homolog 2
- SH3-containing GRB2-like protein 3-interacting protein 1
- Synaptojanin-1
- AP-2 complex subunit beta
- AP-2 complex subunit mu
Sequence:
MAAPLVPLSQQIPGGNPLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSSLSLTMPPPKFHDTSSPLMATQSSAETHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSILPPPLIPPSKRKKTVFAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQPPVAWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSTLASGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQVPDGVSGTSLPDLATLNEGILLAERGGFGAMDDPFKNKALLFSNNSQELHPDPFQAEDPFKSDPFKGADPFKGDPFQSDPFSEQQTAATDPFGGDPFKESDPFHSSSSDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLDPFGSSSFSSAEGFADFSQMSKPPPSGPFSSSLGGTGFSDDPFKSKQDTPALPPKKPAPPRPKPPSGQSTPVSQLGSSDFPESPDPFQPLGADSGDPFQNKKGFGDPFSGKDPFAPSSSAKPPKTSSSGFADFTSFGNEEQQLAWAKRESEKAEQERLARLRRQEQEDLELAIALSKADMPA
Protein: Smoothelin-like protein 1 (A8MU46)
Organism: Homo sapiens (Human)
Function: Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).
Subcellular location: Cytoplasm, myofibril {ECO:0000269|PubMed:18310078}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity). {ECO:0000250}.
Interaction partners:
- Protein phosphatase 1 regulatory subunit 12A
- cGMP-dependent protein kinase 1
- Smoothelin
- PDZ and LIM domain protein 3
Sequence:
MEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK
Protein: Uncharacterized protein YDL241W (Q07738)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Protein FMP32, mitochondrial
Sequence:
MNVTENALLFKCGSKGYINQTYTPTEIYNCGVAEGKKTAKEKNPTYSIFYDTFLTGQPAESPETFTCGSHGFTNASYVASDFYACGFLQGKGTETNAGIHNTRPSHSLAKFTILFMLVLYTIV
Protein: hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) (Q5B2F7)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase
- Mitochondrial methylglutaconyl-CoA hydratase
- Acetoacetyl-CoA synthase
- Acetoacetyl-CoA synthase
- Succinyl-CoA:3-ketoacid-coenzyme A transferase
- Succinyl-CoA:3-ketoacid-coenzyme A transferase
- Succinyl-CoA:3-ketoacid-coenzyme A transferase
- acetyl-CoA C-acetyltransferase
- acetyl-CoA C-acyltransferase
- acetyl-CoA C-acyltransferase
Sequence:
MQNSTKTVRIVEVGPRDGLQNIPQSIDSTIKLDLIRRLRDAGLQTIELTSFVSPRAIPQLADAQVVVQNADIQKLLKNPKLRLPVLVPNLKGLERALHNGIKEVAVFISATEGFSRANINCTVDEGLERARQVASRAASAGLSVRGYVSCIFADPYDGPTRPSSVLRCTKALLDAGCYEVSLGDTLGIGTPADVRWLITYLQDNGVPLEMLAGHFHDTYGGAVANVWEAYKCGLRMFDSSVAGLGGCPFALGAKGNVASEDLVYMFERSGIHTGVDLSKLVETGEWISRQLSIANSSRAGAALWAMRKQTAVPKSPKVSVSWKLVKQTEGLQLFRSGVNLRINLNRPKNGNALTAIMAQDLTEAVTNAGRDATISRIILTGSGKFFCTGMDLGKGSTAVGQGGSSSNAQFDRLTNLFEAIDQSPKVTIACLNGPAFGGGVGLAFACDMRFAVRAASVTLSEVKLGLCPATISKYVIREFGIALSREAMLSARPVSAGELKARGLVVELADNAEALPGLLDQFLTQLKAASPEASRMSKELIRLAWAHGGKEEQAKGIRALFDGMMRPDGDGAHGVKEFQAKRSVDWDAYTLRRVDSAKL
Protein: Transmembrane protein, putative (DUF594) (Q9FHI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MVEVIPKHIKDVWDRWNIRGAVILSLTLQAILICFSPLRKRTPRRLLIVLVWSSYLLADWSANFAVGLISKNQGKDLKPDDPPQDKKVMALWAPFLLLHLGGPDTITAFALEDNALWLRHVFGLVFQAIAGVYVVVMSLPNSLWVVIVLVFVSGTIKYLERTTALYSASLDKFRDSMIQAPDPGPNYAKLMEEYKAKKEARLPTKIVLIDEPDKENRPKKLEHPALASKKRKKDLTDLEIVQYAYKFFNTFKGLVVNLIFSFRERDESLEIFENLNDPEEALRIIEIELGFLYDALFTKIAILHTGIGTVSRVFASGTLVAAFIIFHKKPNKGTDFHGADVVVTYTLFAVGLVLDFISILLFLFSDWTCAAYSSLKDDPDELQSWQERCFNWLLKFRKLRWTPQECHKTGMHKCTKEGLKPCIMKGADKKEGGNKNEGGNKKEGDDKKEAADKCSLVDKHDVLTTRFFLRRWSGSINVFNFIAYATKADVERIHDARGSFRRYSWKIITFPFKKLNFVIKKIFGSIVKLINEVHRRISHEVNALSRKHLWARRFLYPIYFEFISRIPHFIKSVWDILSEFFDISDTLDMVHKTLFVHGEPMTRELWKFIFEELKNKSKYGDSPENAKRISLARGEWTLRENLPVDAEREKLVRYVTKVDYDQSLLMWHIATELCYQQHEKETIPEGYDEQRKHYSNREFSKIISDYMMYLLILQPGLMSEVAGIGKIRFRDTLAETHKFFQRRHIENDRSVETATLNILDVESEIEPMGVKGDRSKSVLFDASRLAKDLAEMEKTHNKDKWEILSKVWVELLCYAACHCDSTAHVEQLSRGGELINFVWLLMAHFGLTDQFQINKGDARAKLIIGK
Protein: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 (Leucine-rich repeat-containing protein 21) (Photoreceptor-associated LRR superfamily protein) (Retina-specific protein PAL) (Q9JMH2)
Organism: Rattus norvegicus (Rat)
Function: Possible role in phototransduction.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10777785}; Single-pass type I membrane protein {ECO:0000269|PubMed:10777785}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8K099}.
Interaction partners:
- Leucine-rich repeat, Ig-like and transmembrane domains 2
- EP300-interacting inhibitor of differentiation 2B.
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L2
Sequence:
MWVALGMLWLLALGGPHQAWSFCPSQCSCSLHILSDGSKARTVVCSDPDLTLPPASIPPDTCKLRLERTAIRRVPGETFRPLSRLEQLWLPYNALSELSTLMLRGLRRLRELRLPGNHLVTFPWAALKDTPQLQLLDLQANRLSTLPPEAVHFLENLTFLDLSNNQLMRLPEELLDTWAHLKTGPYLSSRRTRLVLGLQDNPWVCDCRLYDLVHLLDGWASNLIFIEARLRCGSPRSLAGVAFSQLELRKCQSPELRPGVTSIISPLGSTVLLRCGATGIPGPEMSWRRANGRPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGASETLISLIVTEPQTSTEYTGIPGALWARTGEGAEAAAYNNKLVARHVPHVPEPVALATKPSVPSIKEELPLQNFQMDVPGEFSREPSEHQETQMVRSLKVVGDTYHSVSLVWKAPQAGNTTAFSVLYAVFGQRDMRRMTVEAGKTSVTIEGLAPKTKYVACVCVRGLVPTKEQCVIFSTDEVVDAEGTQRLINMVVISVAAIIALPPTLLVCCGALRRRCHKCRAGGSAEASGAYVNLERLGHSEDGSEELSRSSLSEADRLLSARSSLDSQVLGVRGGRRINEYFC
Protein: GH27705p (Q8MSH1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSRKMLQVPVATLVLLSLLPIAHVAAASATAADATAATAASTTSTGIDASLKNAKLIEAKVLPDLAILQRVNQEDEKWQQVYRFIDDGFPVLELYGYKPLPDLPYTLIVPKIDVRSIEKPRLKEFMLEHVVPGKIFDSYNGNGNSKEEEESFGNGNGHKIVFRKLEKSHNNVWLLNGQQILHKLRINENLMAIAIDGYLGDRKSPYSKRNIQETNNRYNDPQPLEQPNITNAHAKVEPVIKESKASPLMSFLANMKTGTKVFQHFLSKSNLTRIMDDNAYTVLIPSDNAFQRWHPIDWGFYPFSVPEFTESVLRNHFLPMQRPLRLADVRNMDEVVVTTMGGEDVVFHGQPTPTVNNVSIMSDYNLSNGNQVFIISEVLFVTEAVVSKLHQMHKDKETPPLLAFPWFGAQFLSHSFLALERDPRFTQITRYLNSAEIAPHISGANYTFFVPEDRAFEKQGFNKLSDEVMASQRGVKMLLNHFVKGRLYNRDLRDNEVFETIGGGHIKITRNPGSNYTSVNNAQITESEVFVYNLGTMYYLDDILYSHMLRDFVSKSTKTRSNRHGSDSGGGSRSTSRPSDVEIVPNEFEGEHNGGDYAIHGDDEDFEDEIITPKALPVQIYELPK
Protein: Squalene synthase LSS (EC 2.5.1.21) (A0A144YEA5)
Organism: Botryococcus braunii (Green alga)
Function: Converts farnesyl diphosphate (FPP) into squalene, a precursor for sterol biosynthesis in eukaryotes.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGKLQEVLKHPDELVPLMQMLVSDYYTKIVPRDPGLGFCYRMLNKVSRSFAIVIQQLPELLRDPICVFYLVLRALDTVEDDMALPNDIKLPLLRAFHKKIYDRKWSMKCGYGPYVQLMEEYPMVTGVFLKLDPGPREVITEICRKMGAGMAEFIPKEVLTVKDYDQYCHYAAGLVGEGLSKLAVGSGLENPVLLQKEDLSNHMGLFLQKTNIVRDYLEDINEEPAPRMFWPKEIWGKYTKDLADFKDPANEKGAVQCLNHMVTDALRHGEHALKYMALLRDPQYFNFCAIPQVMAFGTLSLCYNNPQVFKGVVKLRKGESAKLMTTVKSMPALYRTFLRMADDMVARCKGEARQDPNVATTLKRLQAIQAVCKTGLRSSIKSRKKQAATPLSDDFISKLVLVLGLGYCVYAFNLLPLLWKSALIPGPPPPALTSSLGLPHQIIAVFCVLTAGYQVFLRGGLA
Protein: High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein HMGX1) (Inhibitor of BRAF35) (iBRAF) (Q9DC33)
Organism: Mus musculus (Mouse)
Function: Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
Interaction partners:
- Genetic suppressor element 1
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
- REST corepressor 3
- PHD finger protein 21A
- Lysine-specific histone demethylase 1A
- Histone deacetylase 2
- REST corepressor 2
- PHD finger protein 21B
- PHD finger protein 14
- REST corepressor 1
Sequence:
MESLMASSTLPPLFADEDGSKESNDLATSGLTHPEGPYGSAATSTTNPEFVEDLSQGQLLQSEASNAVEGNEQRPEDEQRSKRGGWSKGRKRKKPLRDSNAPKSPLTGYVRFMNERREQLRAKRPEVPFPEITRMLGNEWSKLPPEEKQRYLDEADRDKERYMKELEQYQKTEAYKVFSRKTQDRQKGKSHRQDAARQATHDHEKETEVKERSVFDIPIFTEEFLNHSKAREAELRQLRKSNMEFEERNAALQKHVESMRTAVEKLEVDVIQERSRNTVLQQHLETLRQMLTSSFASMPLPGSGEIPTVDTIDSYMNRLHSIILANPQDNENFIATVREVVNRLDR
Protein: Rugosin-LK2 (C3RT24)
Organism: Limnonectes kuhlii (Kuhl's Creek frog) (Rana kuhlii)
Function: Has antimicrobial activity against Gram-positive bacteria S.aureus ATCC 2592 (MIC=10.0 uM), S.aureus ATCC 43300 (MIC=10.0 uM) and B.subtilis (MIC=30.0 uM), against Gram-negative bacteria E.coli ML-35P (MIC=10.0 uM), P.aeruginosa PA01 (MIC=2.5 uM) and P.aeruginosa ATCC 27853 (MIC=2.5 uM) and against fungus C.albicans ATCC 2002 (MIC=10.0 uM).
Subcellular location: Secreted {ECO:0000255, ECO:0000269|PubMed:23054029}.
Interaction partners:
Sequence:
MFTMKKSLLFLFFLGTISLSFCEGERSADEDDEGEMTEEEKRSIRDKGKTIAIDLAKSAGTGVLKTLMCKLDKSC
Protein: Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Q9VPH7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Protein Pixie
- Eukaryotic translation release factor 3, isoform A
- Serine/threonine-protein kinase Smg1
- Regulator of nonsense transcripts 1 homolog
- Elongation factor 1-alpha 2
- Elongation factor 1-alpha 1
- Large ribosomal subunit protein uL2
- Uncharacterized protein, isoform A
- Small ribosomal subunit protein uS2
- Protein pelota
Sequence:
MSGEETSADRNVEIWKIKKLIKSLEMARGNGTSMISLIIPPKDQISRVSKMLADEFGTASNIKSRVNRLSVLGAITSVQHRLKLYTKVPPNGLVIYCGTIVTEEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLADDNKFGFIVMDGNGALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAEVATQLFITNDKPNIAGLILAGSADFKTELSQSDMFDPRLQSKVIKLVDVSYGGENGFNQAIELAAESLQNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLRALELGSVETLICWENLDIQRYVLKNHANSTSTTVLHLTPEQEKDKSHFTDKESGVEMELIESQPLLEWLANNYKMFGATLEIITDKSQEGSQFVRGFGGIGGILRYKVDFQSMQLDELDNDGFDLDDY
Protein: Killer cell lectin-like receptor 8 (Lymphocyte antigen 49h) (Ly-49h) (T-cell surface glycoprotein Ly-49H) (Q60682)
Organism: Mus musculus (Mouse)
Function: Receptor on natural killer (NK) cells for class I MHC.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- TYRO protein tyrosine kinase-binding protein
- Killer cell lectin-like receptor subfamily A member 9
- Natural cytotoxicity triggering receptor 1
- NKG2-D type II integral membrane protein
- Killer cell lectin-like receptor 7
- Killer cell lectin-like receptor subfamily G member 1
- Natural killer cells antigen CD94
Sequence:
MSEQEVTFPTMRFHKSSGLNSQVRLEGTQRSRKAGLRVCSVPWQLIVIALGILCSLRLVIVAVFVTKFFQYSQHKQEINETLNHRHNCSNMQRDFNLKEEMLTNKSIDCRPSYELLEYIKREQERWDSETKSVSDSSRDTGRGVKYWFCYGTKCYYFIMNKTTWSGCKANCQHYSVPIVKIEDEDELKFLQRHVILESYWIGLSYDKKKKEWAWIHNGQSKLDMKIKKMNFTSRGCVFLSKARIEDTDCNTPYYCICGKKLDKFPD
Protein: Antitoxin VapB39 (P9WJ23)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC39.
Interaction partners:
- Ribonuclease VapC39
- Probable amino acid decarboxylase
Sequence:
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV
Protein: At2g33630/F4P9.40 (NAD(P)-binding Rossmann-fold superfamily protein) (Putative steroid dehydrogenase) (O22813)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Ergosterol biosynthetic protein 28
- Methylsterol monooxygenase 2-1
- Putative Delta
- Methylsterol monooxygenase 2-2
- Delta
- NAD
- 24-methylenesterol C-methyltransferase 3
- 24-methylenesterol C-methyltransferase 2
- Probable 3-beta-hydroxysteroid-Delta
- Putative sterol 14-demethylase-like protein
Sequence:
MHLSENEGVEGNTFVVTGGLGFVGAALCLELVRRGARQVRSFDLRHSSPWSDDLKNSGVRCIQGDVTKKQDVDNALDGADCVLHLASYGMSGKEMLRFGRCDEVNINGTCNVLEAAFKHEITRIVYVSTYNVVFGGKEILNGNEGLPYFPLDDHVDAYSRTKSIAEQLVLKSNGRPFKNGGKRMYTCAIRPAAIYGPGEDRHLPRIVTLTKLGLALFKIGEPSVKSDWIYVENLVLAIILASMGLLDDIPGREGQPVAAGQPYFVSDGYPVNTFEFLRPLLKSLDYDLPKCTISVPFALSLGKIFQGFYTVLYPWLSKSWLPQPLVLPAEVYKVGVTHYFSYLKAKEELGYVPFKSSKEGMAATISYWQERKRRSLDGPTMFTWIAVTIGMSALFAAGWLPDIGPVPFLRAIHLFFFRTITIVKAVFIVAVVLHVAEGIYAWFLAKRVDPGNAMGWFLQTSALGFFSMRFLLKRAKEHQI
Protein: Delta-like protein (Q5TZK7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
Interaction partners:
Sequence:
MWNCIRIRNWLPIACLLLTMWTKVSQSSGYFELQLIAVENVNGELWDGECCDSTRNSQDQRCVRDECDTYFKVCLKEYQSEVTTTGQCTFGSGSTDVLGGNIISFKTAKNSPSKTSDVGKIIIPFHFAWPRSYTLILEAWDWDNSTQNNGEENLIERHIHASMVNPGDHWQSIRHPGITAHIEYRIRVRCDENYYGSKCNKQCRPRDDYFGHYRCDPSGNIVCLDGWMGEDCRTAICKQGCNLIHGGCAVPGECKCNYGWQGQFCDECLPYPGCLHGTCVMPWQCTCEKNWGGLLCDKDLNYCGTHHPCVNGGTCMNSEPDEYNCACPEGYSGKNCEIAEHACVSNPCANGGTCHEVPTGFECHCPPGWEGPTCAKDMDECASSPCAQGGTCIDLENGFECVCPPQWVGKTCQIDLNGCHGQCQNGATCKELVHGGYHCQCPAGFVGLHCEVSRNKCASGPCQNGGRCHVILDSFVCECPSNYAGMLCEVESLSHPNPCEPNPCQNTALCYSLPGDFYCACPEDYEGKTCENRKDHCKMTPCQVIDSCTIAVASNSSDGGVRHINSNVCGPHGRCISQPGGNFTCTCELGFTGTYCHENVNDCVSNPCRNGGTCIDGISSFQCFCPDGWEGDLCSINVNECSRSPCKNGGHCVDLVNDFYCECANGWKGKTCHSRESQCDSSTCSNGGTCYDHGDAFRCACPPGWEGSTCNTAKNSTCASGPCLNGGTCVGGGDTFTCICKDGWEGATCAQNTNDCNPHPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGFRCVCPLGRTGPQCQEFIGIGKTCHYAGLQFPHGSRWEEECNTCQCVNGKVECTKVVCGRKPCLLPGTPGRELHYCPGGRECLEHNFLTCLSPPCHQWGFCSSPETPPTLQTKCEPNSVYLDKSCARITLIFNRDKLPTGTTVENVCSELRYMPATRSLAKDHKLLVLCDLSYKNQDAVEVAISFQQDEQPSHSQIQEAASTIVSTLSKRHNSTVMLAVIEVKVEMPVTSQPVDYLVPVLCVVLCVLWVFCVIVCVWWTRKRRKERERCERVPVEESVNNQWEPLRPVTRPQHKDNRDAQFERTKLMGSPDRTCNSGDDEEDMEEDELELVEEWCGTEGGKHPVQKYSKSAARTKNGLICTTRSTSGSSSPSLKAAYWTGFSPKDNNCKNVNNATAGQEHKEHCV
Protein: RNA helicase (EC 3.6.4.13) (Q8IV96)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICTVC
Protein: Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) (Q99700)
Organism: Homo sapiens (Human)
Function: Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Polyadenylate-binding protein 1
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- RNA binding protein fox-1 homolog 1
- Ataxin-3
- Probable ATP-dependent RNA helicase DDX6
- TAR DNA-binding protein 43
- Protein LSM12
- Ataxin-1
- Ataxin-3-like protein
- Ataxin-2-like protein
Sequence:
MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPGSRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASPPRSGVSLARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL