wanglab/gogpt-training-data huggingface dataset:
Protein: Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] (P68136)
Organism: Rattus norvegicus (Rat)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Unconventional myosin-XV
- Myosin light chain 1/3, skeletal muscle isoform
- Vasodilator-stimulated phosphoprotein
- Myosin regulatory light chain 11
- Troponin C, skeletal muscle
- Unconventional myosin-Ib
- Myosin-4
- Tropomyosin beta chain
- Calmodulin-1
- Myosin regulatory light chain RLC-A
Sequence:
MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
Protein: NACHT, LRR and PYD domains-containing protein 1b allele 3 (Q2LKV5)
Organism: Mus musculus (Mouse)
Function: May act as the sensor component of the Nlrp1b inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (By similarity). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (By similarity). May act as a recognition receptor (PRR), which recognizes specific pathogens and other damage-associated signals and forms an inflammasome complex: the inflammasome directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (By similarity). In the absence of GSDMD expression, the Nlrp1b inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) (By similarity). Contrary to Nlrp1b allele 1, allele 3 is not activated by Bacillus anthracis lethal toxin. The absence of autocatalytic cleavage within the FIIND domain, which regulates activation in other alleles, suggests that allele 3 may be non-functional.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q2LKW6}.
Interaction partners:
Sequence:
MEESPPKQKSNTKVAQHEGQQDLNTTRHMNVELKHRPKLERHLKLGMIPVVYMKQREEILYPAQSLKEENLIQNFTSLPLLQKLYPKDPENMVRKSWASCIPEEGGHMINIQDLFGPNIGTQKEPQLVIIEGAAGIGKSTLARLVKRAWKEGQLYRDHFQHVFFFSCRELAQCKKLSLAELIAQGQEVPTAPINQILSHPEKLLFILDGIDEPAWVLADQNPELCLHWSQRQPVHTLLGSLLGKSILPEAFFLLTTRTTALQKFIPSLPMPCQVEVLGFSGIERENYFYKYFANQRHAITAFMMVESNPVLLTLCEVPWVCWLVCTCLKKQMEQGRVLSLKSQTTTALCLKYPSLTIPDKHRRTQVKALCSLAAEGIWKRRTLFSESDLCKQGLDEDAVATFLKTGVLQKQASSLSYSFAHLCLQEFFAAISCILEDSEERHGNMEMDRIVETLVERYGRQNLFEAPTVRFLFGLLGKEGVKGMEKLFSCSLHGKTKLKLLWHILGKSQPHQPSCLGLLHCLYENQDMELLTHVMHDLQGTIVPGPNDIAHTVLQTNVKQLVVQTDMELMVATFCIQFYCHVRTLQLNMEKQQGYALTSPRMVLYRWTPITNASWEILFYNLKFTRNLEGLDLSGNSLRYSVVQSLCNTLRYPGCQLKTLWLVKCGLTSRYCSLLASVLSAHSSLTELYLQLNDLGDDGVRMLCEGLRNPVCNLSILWLDLSSLSAQVITELRTLEEKNPKLYIRSIWMPHMMVPTENMDEEAILTTFKQQRQESGDKPMEILGTEEDFWGPTGPVATELVDRVRNLYRVQLPMAGSYHCPSTGLHFVVTRAVTIEIEFCAWSQFLDKTPLQQSHMVVGPLFDIKAEQGAVTAVYLPHFVSLKDTEASTFDFKVAHFQEHGIVLETPDRVKPGYTVLKNPSFSPMGDVLRIIPADRHFIPITSITLIYYRLNLEEVTLHLYLVPSDCTIQKAIDDEEMKFQFVRINKPPPVDNLFIGSRYIVSGSENLEITPKELELCYRSSKEFQLFSEIYVGNMGSEIKLQIKNKKHMRLIWEALLKPGDLRPALPRIAQALKDAPSLLHFMDQHREQLVARVTSVDPLLDKLHGLVLNEESYEAVRAENTNQDKMRKLFNLSRSWSRACKDLFYQALKETHPHLVMDLLEKSGGVSLGS
Protein: Squamosa promoter-binding-like protein 14 (Protein FUMONISIN B1-RESISTANT 6) (SPL1-related protein 2) (Q8RY95)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3' (By similarity). May play a role in plant development.
Subcellular location: Nucleus {ECO:0000269|PubMed:15703061}. Cytoplasm {ECO:0000269|PubMed:15703061}. Note=Mostly located in the nucleus.
Interaction partners:
- Selenium-binding protein 2
- Protein LAZY 1
Sequence:
MDEVGAQVAAPMFIHQSLGRKRDLYYPMSNRLVQSQPQRRDEWNSKMWDWDSRRFEAKPVDVEVQEFDLTLRNRSGEERGLDLNLGSGLTAVEETTTTTQNVRPNKKVRSGSPGGNYPMCQVDNCTEDLSHAKDYHRRHKVCEVHSKATKALVGKQMQRFCQQCSRFHLLSEFDEGKRSCRRRLAGHNRRRRKTTQPEEVASGVVVPGNHDTTNNTANANMDLMALLTALACAQGKNAVKPPVGSPAVPDREQLLQILNKINALPLPMDLVSKLNNIGSLARKNMDHPTVNPQNDMNGASPSTMDLLAVLSTTLGSSSPDALAILSQGGFGNKDSEKTKLSSYENGVTTNLEKRTFGFSSVGGERSSSSNQSPSQDSDSRGQDTRSSLSLQLFTSSPEDESRPTVASSRKYYSSASSNPVEDRSPSSSPVMQELFPLQASPETMRSKNHKNSSPRTGCLPLELFGASNRGAADPNFKGFGQQSGYASSGSDYSPPSLNSDAQDRTGKIVFKLLDKDPSQLPGTLRSEIYNWLSNIPSEMESYIRPGCVVLSVYVAMSPAAWEQLEQKLLQRLGVLLQNSPSDFWRNARFIVNTGRQLASHKNGKVRCSKSWRTWNSPELISVSPVAVVAGEETSLVVRGRSLTNDGISIRCTHMGSYMAMEVTRAVCRQTIFDELNVNSFKVQNVHPGFLGRCFIEVENGFRGDSFPLIIANASICKELNRLGEEFHPKSQDMTEEQAQSSNRGPTSREEVLCFLNELGWLFQKNQTSELREQSDFSLARFKFLLVCSVERDYCALIRTLLDMLVERNLVNDELNREALDMLAEIQLLNRAVKRKSTKMVELLIHYLVNPLTLSSSRKFVFLPNITGPGGITPLHLAACTSGSDDMIDLLTNDPQEIGLSSWNTLRDATGQTPYSYAAIRNNHNYNSLVARKLADKRNKQVSLNIEHEVVDQTGLSKRLSLEMNKSSSSCASCATVALKYQRRVSGSQRLFPTPIIHSMLAVATVCVCVCVFMHAFPIVRQGSHFSWGGLDYGSI
Protein: Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) (O60814)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Interaction partners:
- Histone H3.1
- Histone H4
- Histone H2A type 2-A
- Histone H3.2
- Histone H2A type 1-C
- Histone H2A type 2-C
- Histone H2A type 1-B/E
- Histone H3.1t
- Histone H3.3
- Histone H2A type 1
Sequence:
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK
Protein: DDRGK domain-containing protein 1 (D3ZAS9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- E3 UFM1-protein ligase 1
- CDK5 regulatory subunit-associated protein 3
- Ubiquitin-fold modifier 1
- Ubiquitin-fold modifier-conjugating enzyme 1
Sequence:
MVVGGAWRSGSRRRAGVAARLSVVMVGPWVYLVAAVLLIGLILFLTRSRGRAAAADGEPLHNEEERTGAGQVARSWPQESEEQRTGGRPRRRRDLGSRLQAQRRAQRVTWEEVDENEGEAAVPAQEEEGVEKPAEVHPTGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLKEEQKEEEERKAREEQARREHEEYLKLKEAFVVEEEGVSETMTEEQSHSFLTEFINYIKQSKVVLLEDLAFQMGLRTQDAINRIQDLLTEGTLTGVIDDRGKFIYITPEELAAVASFIRQRGRVSITELAQASNSLISWGQDLPAQASV
Protein: Homeobox protein knotted-1-like 6 (Protein KNAT6) (Q84JS6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in meristem function. Contributes to the shoot apical meristem (SAM) maintenance and organ separation by controlling boundary establishment in embryo in a CUC1, CUC2 and STM-dependent manner. Involved in maintaining cells in an undifferentiated, meristematic state. Probably binds to the DNA sequence 5'-TGAC-3'.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein ASYMMETRIC LEAVES 2
- Transcription factor AS1
- Protein KNATM
- BEL1-like homeodomain protein 9
- Regulatory protein NPR5
- Axial regulator YABBY 1
- Axial regulator YABBY 5
- Protein CUP-SHAPED COTYLEDON 3
- Protein CUP-SHAPED COTYLEDON 1
- LRR receptor-like serine/threonine-protein kinase HSL2
Sequence:
MDGMYNFHSAGDYSDKSVLMMSPESLMFPSDYQALLCSSAGENRVSDVFGSDELLSVAVSALSSEAASIAPEIRRNDDNVSLTVIKAKIACHPSYPRLLQAYIDCQKVGAPPEIACLLEEIQRESDVYKQEVVPSSCFGADPELDEFMETYCDILVKYKSDLARPFDEATCFLNKIEMQLRNLCTGVESARGVSEDGVISSDEELSGGDHEVAEDGRQRCEDRDLKDRLLRKFGSRISTLKLEFSKKKKKGKLPREARQALLDWWNLHYKWPYPTEGDKIALADATGLDQKQINNWFINQRKRHWKPSENMPFAMMDDSSGSFFTEE
Protein: DRE binding protein 1 (Dehydration responsive element binding protein) (Ethylene-responsive transcription factor RAP2-1-like) (Q7XAV5)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Tubulin alpha-4 chain
Sequence:
MELGDCCLTSSPASGEKRKLHRTQQKEKPFRGIRMRKWGKWVAEIREPNKRSRIWLGSYTTPVAAARAYDTAVFYLRGPSARLNFPDLIFQEDELRDISAASIRKKATEVGAKVDALQTSLHHASASSSESSNPTRVFRKPDLNKYPDSSDED
Protein: Malate dehydrogenase, mitochondrial (EC 1.1.1.37) (Q9VEB1)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Malate dehydrogenase
- Probable citrate synthase, mitochondrial
- Aspartate aminotransferase
- Citrate synthase
- Aspartate aminotransferase, cytoplasmic
- fumarate hydratase
- fumarate hydratase
- Isocitrate dehydrogenase
- Dihydrolipoyl dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase 1
Sequence:
MLKQVTKQLALQGVRTFSVGQQNNYKVTVCGAAGGIGQPLSLLLKQNPLVTDLALYDIVHTPGVAADLSHIDTKSKTAGFIGADQLGDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAKNCPKALVAIITNPVNTCVPIAAEILKKAGVYDPKRLFGVSTLDVVRARAFIGHALGVDPQTVQIPVIGGHSGVTILPVLSQSQPLFKGNQDTIEKLTVRIQEAGTEVVKAKAGAGSATLSMAYAGARFAGSLLKGLNGEKNVIECSYVQSTVTEATFFSTPLVLGKNGVQENLGLPKLNDYEKKLLEAAIPELKKNIQKGIDFANA
Protein: Terminase, large subunit (DNA-packaging protein) [Includes: ATPase (EC 3.6.4.-); Endonuclease (EC 3.1.21.-)] (Q6QGD2)
Organism: Escherichia phage T5 (Enterobacteria phage T5)
Function: The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer. Once the capsid is packaged with the DNA, the terminase complex is substituted by the tail.
Interaction partners:
Sequence:
MEVSRPYVNTVDVIDFGIDKRFFRLPVSGILAQEGITPNGPQIAIINALEDPRHRFVTACVSRRVGKSFIAYTLGFLKLLEPNVKVLVVAPNYSLANIGWSQIRGLIKKYGLQTERENAKDKEIELANGSLFKLASAAQADSAVGRSYDFIIFDEAAISDVGGDAFRVQLRPTLDKPNSKALFISTPRGGNWFKEFYAYGFDDTLPNWVSIHGTYRDNPRADLNDIEEARRTVSKNYFRQEYEADFSVFEGQIFDTFNAIDHVKDLKGMRHFFKDDEAFETLLGIDVGYRDPTAVLTIKYHYDTDTYYVLEEYQQAEKTTAQHAAYIQHCIDRYKVDRIFVDSAAAQFRQDLAYEHEIASAPAKKSVLDGLACLQALFQQGKIIVDASCSSLIHALQNYKWDFQEGEEKLSREKPRHDANSHLCDALRYGIYSISRGK
Protein: Protein trunk (Q24155)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for activity of the tor receptor, could be a ligand of tor. Involved in specifying terminal body pattern.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Torso-like protein
- Female sterile
- Tyrosine-protein kinase receptor torso
- EG:8D8.1 protein
Sequence:
MKSQSELAIVLTWLAVLGTAQDDADYCAELSTQSLAKILGQAFNPRYMSIDPPGEPEEKSYHLGYKRSSYELPFYADSDAISVSHFPAWETNHFALVEKKKEAPRSKSLRTRSAFMDRVGHPRIDGFKQRPWECSSKINWIDLGLNYFPRYIRSIECIARKCWYDHFNCKPKSFTIKVLRRKTGSCIRINDKLILITAEKFENDYTQLWIWEEIAVNFCCECVMLY
Protein: Glucose transporter 1E (Q09037)
Organism: Trypanosoma brucei brucei
Function: Facilitative glucose transporter.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MTERRDNVSHAPDAIEGPNDGAHAEETSPGFFSFENLGVAQVQVVGGTLNGYVIGYVAVYLLLYLTATECKFTTEGACGGRKIYGCKWSGTTCKFENPKCSEGSDPSDSCKNEVAYTSVYSGIFACAMIVGSMVGSIIAGKCITTFGLKKSFIIVSITCTIACVVVQVAIEYNNYYALCTGRVLIGLGVGILCSVFPMYVNENAHPKLCKMDGVLFQVFTTLGIMLAAMLGLILDKTGASKEEANMAGRLHVFSAVPLGLSVAMFLVGMFLRESTATFAQDDDGKADGGMDPNEYGWGQMLWPLFMGAVTAGTLQLTGINAVMNYAPKITENLGMDPSLGNFLVMAWNFVTSLVAIPLASRFTMRQMFITCSFVASCMCLFLCGIPVFPGVAEEKVKNGVATTGIALFIAAFEFGVGSCFFVLAQDLFPPSFRPKGSSFVVMMQFIFNILINLLYPITTEAISGGATGDQDKGQAVVFILFGLIGLICFVLQFFYLYPYDANQDHENDHGTEPVERILSPVDVPTPRN
Protein: Nuclear hormone receptor family member nhr-22 (Q09587)
Organism: Caenorhabditis elegans
Function: Orphan nuclear receptor.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Interaction partners:
- Guanine nucleotide-binding protein alpha-7 subunit
- Nuclear Hormone Receptor family
Sequence:
MSTDLLYEYFYPPTDLFKNTFEDVPPSPESLDVGDSLGSSPSYDLGFQPSFDIDFCIWKEGSSSPPPESNHLPEIVNKASTSPRGMPSPLTDSRSCHVCSSPTANTLHFGGRSCKACAAFFRRSVSMSMTYECIGTGDDTNPCRTHYELRMICRHCRFIKCLDAGMRRELVQARKEETRVAKRRSKGLVVSKKEDDDVESSYDEYVNTYTNVQDSSPKMESGINEMTIPESYLSPDPSSSQPLDMTVTPPPLHRSTPSILLTPATGDRMHCQRVLSNSPPFDIHQASTSHAGFIQHVQFYPVVEVENKIFELVDHYVRTEASLNDRRKIMYTDTQIRDVFDTTCECPYENHQLKPFNYKSFCGFVKHDFVMILDYVNQFPEFQALHKNDKNVVYRMACAVDSMLASAYYSYKVGIEKERLILFNGDYINMNPIPISGDEPGAGTEFQTPQEHEKYKTLMPLKLKQYFDLAIPFARLEVSFEEYVLLKALIIWQISNYRLLEEGRAICARQRDTIVQALHKVVEERGDEDPAIRVGQLLLSMSYITEQVQAMTNSYLVMTFFDVVSCDSIMYDLLSFRDD
Protein: GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) (Q99MR1)
Organism: Mus musculus (Mouse)
Function: May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1.
Interaction partners:
- Eukaryotic translation initiation factor 4E type 2
- Probable ATP-dependent RNA helicase DDX6
- Trinucleotide repeat-containing gene 6C protein
- Growth factor receptor-bound protein 10
- E3 ubiquitin-protein ligase ZNF598
Sequence:
MAAETLNFGPEWLRALSSGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEELQDKEFAAVLQEEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLPATSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRNPREIQRSQSWDDRGERRFEKPARRDGVRSGFEEGGAGPRKEHARSDSENWRSLREEQEDDGSWRLGAGPRRDGDRWRSTSPDGGPRSAGWREHGERRRKFDFDLRGERGGCGEEDGRVGGGNSHLRRCRGLDGFEDDKDGLPEWCLEDEDEEMGTFDASGAFLPLKKGPKEAIPEEQELDFRGLEEEEEEEEEPSEGVDEERPEAGGKEATPLPPPENSSSPSSLPALGPLWTTNEEGGEAVEKELPPAEGDELRGLSLSPRISSPPGPPGDLEDEEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSTAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQHFLQLVGSRQLPQCTTLREKAAMGDLTPPQQQQLTTFLQQLQALKTPRGGDQNLLPTMSRSLSVPDSGPLWDLHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQQQEEQKRRQEEEELFRRKQVRQQELLLKLLQQQQATNVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQMESERQLHKQAAPREPLRAQAPNHRVQLGGLGSAPLNQWVSEAGPLWGGPDKSGGSSGGNLGLWEDTLKSGGSLARSLGLKSSRSSPSLSDSYSHLSGRPVRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSTAGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQQQQQQQQQEAWLSSTSLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGPSGEIESVDDY
Protein: Actin-related protein 2 (Actin-like protein 2) (Actin-related protein B) (O96621)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in the rapid activation and adaptation of the actin system to its multiple functions.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11807934}. Cytoplasm, cytosol {ECO:0000269|PubMed:11425877}. Cytoplasm, cell cortex {ECO:0000269|PubMed:11425877}. Cell projection, pseudopodium {ECO:0000269|PubMed:11425877}.
Interaction partners:
- Actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 1
- Actin-related protein 2/3 complex subunit 3
- Actin-related protein 3
- Actin-related protein 2/3 complex subunit 4
- Actin-related protein 2/3 complex subunit 5
- ADF-H domain-containing protein
- Protein SCAR
- Wiscott-Aldrich syndrome protein
- WASP-related protein
Sequence:
MDSNKVIVMDNGTGFVKCGFAGANFPTAIFPSMVGRPILRSEEKVENVEIKDIMVGDEAAKLRSMLQITYPLENGIIRNWDDITHVWDYALKEKLKVSDPTECKILLTEPPMNPVANRQKMIECMFEKYGFQAVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHIIPVYEGYSIPHLTRRLDVAGRDVTRYLIKLLLLRGYAFNRTADFETIRQIKEKLCYVAYDVQQEMKLASETTVLVENYTLPDGRVIKVGQERFQASEALFNPSLVDVEGGGVHEQLFDCITKADRDLQQGFYQHIVLSGGSSMYPGLPSRLEKEIRSLYLERVLKGNKEGLAKFKCRIEDPPRRKHMVFLGGAVLADLTKDRDDFWITKAEYMEKGFGALDKLTKLSV
Protein: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) (Q8CHT0)
Organism: Mus musculus (Mouse)
Function: Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Interaction partners:
- Proline dehydrogenase 1, mitochondrial
- Delta-1-pyrroline-5-carboxylate synthase
- Hydroxyproline dehydrogenase
- Ornithine aminotransferase, mitochondrial
- Pyrroline-5-carboxylate reductase 3
- Pyrroline-5-carboxylate reductase 2
- Pyrroline-5-carboxylate reductase 1, mitochondrial
- Glutamate dehydrogenase 1, mitochondrial
- Aspartate aminotransferase, mitochondrial
- Glutaminase liver isoform, mitochondrial
Sequence:
MLPLPSLRRSLLSHAWRGAGLRWKHTSSLKVTNEPILAFSQGSPERDALQKALKDLKGQMEAIPCVVGDEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDDKYRETLQLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ
Protein: Paired box protein Pax-3 (P24610)
Organism: Mus musculus (Mouse)
Function: Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P23760}.
Interaction partners:
- Transcription factor SOX-10
- Nuclear receptor coactivator 1
- Paired box protein Pax-7
- Myoblast determination protein 1
- Myogenic factor 5
- Myogenin
- Forkhead box protein O1
- Myogenic factor 6
- Zinc finger protein ZIC 1
- Lymphoid enhancer-binding factor 1
Sequence:
MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNADSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLEPTTTVSASCSQRLEHMKNVDSLPTSQPYCPPTYSTAGYSMDPVTGYQYGQYGQSKPWTF
Protein: DNA mismatch repair protein MSH3 (AtMSH3) (MutS protein homolog 3) (O65607)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the post-replicative DNA mismatch repair system (MMR). Forms the heterodimer MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS beta recognizes single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA mismatch repair protein MSH2
- DNA mismatch repair protein MLH1
- DNA mismatch repair protein MLH3
- DNA mismatch repair protein MSH5
- DNA mismatch repair protein PMS1
- Proliferating cell nuclear antigen 2
- DNA mismatch repair protein MSH6
- Exonuclease 1
- Proliferating cellular nuclear antigen 1
- DNA mismatch repair protein MSH7
Sequence:
MGKQKQQTISRFFAPKPKSPTHEPNPVAESSTPPPKISATVSFSPSKRKLLSDHLAAASPKKPKLSPHTQNPVPDPNLHQRFLQRFLEPSPEEYVPETSSSRKYTPLEQQVVELKSKYPDVVLMVEVGYRYRFFGEDAEIAARVLGIYAHMDHNFMTASVPTFRLNFHVRRLVNAGYKIGVVKQTETAAIKSHGANRTGPFFRGLSALYTKATLEAAEDISGGCGGEEGFGSQSNFLVCVVDERVKSETLGCGIEMSFDVRVGVVGVEISTGEVVYEEFNDNFMRSGLEAVILSLSPAELLLGQPLSQQTEKFLVAHAGPTSNVRVERASLDCFSNGNAVDEVISLCEKISAGNLEDDKEMKLEAAEKGMSCLTVHTIMNMPHLTVQALALTFCHLKQFGFERILYQGASFRSLSSNTEMTLSANTLQQLEVVKNNSDGSESGSLFHNMNHTLTVYGSRLLRHWVTHPLCDRNLISARLDAVSEISACMGSHSSSQLSSELVEEGSERAIVSPEFYLVLSSVLTAMSRSSDIQRGITRIFHRTAKATEFIAVMEAILLAGKQIQRLGIKQDSEMRSMQSATVRSTLLRKLISVISSPVVVDNAGKLLSALNKEAAVRGDLLDILITSSDQFPELAEARQAVLVIREKLDSSIASFRKKLAIRNLEFLQVSGITHLIELPVDSKVPMNWVKVNSTKKTIRYHPPEIVAGLDELALATEHLAIVNRASWDSFLKSFSRYYTDFKAAVQALAALDCLHSLSTLSRNKNYVRPEFVDDCEPVEINIQSGRHPVLETILQDNFVPNDTILHAEGEYCQIITGPNMGGKSCYIRQVALISIMAQVGSFVPASFAKLHVLDGVFTRMGASDSIQHGRSTFLEELSEASHIIRTCSSRSLVILDELGRGTSTHDGVAIAYATLQHLLAEKRCLVLFVTHYPEIAEISNGFPGSVGTYHVSYLTLQKDKGSYDHDDVTYLYKLVRGLCSRSFGFKVAQLAQIPPSCIRRAISMAAKLEAEVRARERNTRMGEPEGHEEPRGAEESISALGDLFADLKFALSEEDPWKAFEFLKHAWKIAGKIRLKPTCSF
Protein: Ras-related protein Rab-7a (EC 3.6.5.2) (A0A158RFU6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, autophagosome membrane {ECO:0000256|ARBA:ARBA00037866}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037866}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037866}. Cytoplasmic vesicle, phagosome membrane {ECO:0000256|ARBA:ARBA00037824}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037824}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037824}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004492}. Lipid droplet {ECO:0000256|ARBA:ARBA00004502}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004630}. Melanosome membrane {ECO:0000256|ARBA:ARBA00037798}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037798}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037798}.
Interaction partners:
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAESCSC
Protein: ATP-dependent helicase fft2 (EC 3.6.4.12) (Fun thirty-related protein 2) (O74842)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Transposon Tf2-11 polyprotein
Sequence:
MLPYNSNYLSDNGKRKFSDENPQSEVYGSSQTGLPSSYGNPQSYGTPPVQQSSAMYGVNNSMGGGMYNTSENTQFMNTDYSQTSSYASTPMSNAYSRDAPAAINNNFGYSYVGQSSQPVPSYNPLPSYNTASLPNAGIPAAMPGMPSGYPGTVPIPQGGYNAHYSSPYNNGYPIGAVNPTSAIPAQPPAQPVNNVLPSYVRSNSRSSARSTARSAPRSTQRSRSSSANPVTTPPVNNTLLTPPAPPVELPPVTTTSPNAIIRSVQWIRSFVPQAPIHQVINTLAQTKWDETAALSILSQKYLSCDLGIPIQEHKRFKQSPVASNMPTYGSSNRTVQSQKRSIRDKYIQMPNDSTQASLMPSYTRKTSNASKKLTTEEDEFYDSEEEPEAIVHRDTSALERTVLNFINSSTAKELSDTASCPLSHSKLLLEHRPFQTLAEACIIKHPDDVPSKPGRRGRRREKNPMGQKIVNACMETMEGYYAIDNLIAKCEFLGNRISKGMASWGIKLEMSNGELNIVDMESVPTEAADNSDFPKFVTEQPKTLASDVQLKSYQLVGVNWLHLLYQQKLSGILADEMGLGKTCQVVAFFALLLEQGHHGPHLVVVPSSTLENWLRELARFCPSLRVEPYYGSQQERANIREAIEENEIKYDILVTTYQLATNNKEDRSFLKHQNFDVCVYDEGHYLKNRMSERYKHLMNLNANFRLLLTGTPLQNNLKELVSLLAFILPNMFDSDMDDLDVIFKAKPTADADIEQALLSKQRISRAKTMMTPFVLRRRKNQVLNDLPKKTQIIEHCKLSENQLEIYNRYAALQKNQQLRRDDKRNKRSKNDEESDGKSLSAGHVLMQLRKAANHALLFRKFYDDEKLKQMAKDIMQEEQYKNANEQYIYEDMEVMSDFELHRLCRSFPTLQSYTLKDDPWMDSGKIRVLKELLPKMKEEGSRILLFSQFTQMLDILEQVLDTLKISYVRLDGSTQVEVRQDIIDQFHKEEDVTVFLLSTKAGGFGINLACANVVILYDCSYNPFDDLQAEDRAHRVGQVREVTVIRLITDNTIEEYIQKLANTKLALDMSLSSDGKDREEIGERLVQDMLDEENNGNNTKPEITGNESDGEFKVSSSNNSKQTDAEETNTGVPLEGSQPNSVEKTDLADGDEKANIKTEMKSETVEGDNKELRETMKGENVQTDSNAAVPSSKSSTEEPNESVLSGHLDLDTEASPVVSTIEKTTKGDVSVTEEQQSANIDGQLEKPEIEESKKPDVLNQVSLSIEEEKPKNKESEVDNNAAKD