wanglab/gogpt-training-data huggingface dataset:
Protein: Scarecrow-like protein 27 (AtSCL27) (GRAS family protein 14) (AtGRAS-14) (Q7XJM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in plant development.
Subcellular location: Nucleus {ECO:0000269|PubMed:18500650}.
Interaction partners:
- Protein PAT1 homolog
- Thiohydroximate-O-sulfate sulfur/sulfate-lyase
- Scarecrow-like protein 9
- Putative scarecrow-like protein 16
- Thiohydroximate-O-sulfate sulfur/sulfate-lyase
- Holliday junction resolvase MOC1, chloroplastic
- Protein S-acyltransferase 11
- Serine/threonine-protein kinase PBL36
Sequence:
MPLSFERFQGEGVFGLSSSSFYSDSQKIWSNQDKTEAKQEDLGYVVGGFLPEPTSVLDALRSPSPLASYSSTTTTLSSSHGGGGTTVTNTTVTAGDDNNNNKCSQMGLDDLDGVLSASSPGQEQSILRLIMDPGSAFGVFDPGFGFGSGSGPVSAPVSDNSNLLCNFPFQEITNPAEALINPSNHCLFYNPPLSPPAKRFNSGSLHQPVFPLSDPDPGHDPVRRQHQFQFPFYHNNQQQQFPSSSSSTAVAMVPVPSPGMAGDDQSVIIEQLFNAAELIGTTGNNNGDHTVLAQGILARLNHHLNTSSNHKSPFQRAASHIAEALLSLIHNESSPPLITPENLILRIAAYRSFSETSPFLQFVNFTANQSILESCNESGFDRIHIIDFDVGYGGQWSSLMQELASGVGGRRRNRASSLKLTVFAPPPSTVSDEFELRFTEENLKTFAGEVKIPFEIELLSVELLLNPAYWPLSLRSSEKEAIAVNLPVNSVASGYLPLILRFLKQLSPNIVVCSDRGCDRNDAPFPNAVIHSLQYHTSLLESLDANQNQDDSSIERFWVQPSIEKLLMKRHRWIERSPPWRILFTQCGFSPASLSQMAEAQAECLLQRNPVRGFHVEKRQSSLVMCWQRKELVTVSAWKC
Protein: Delta(6)-protoilludene synthase (EC 4.2.3.135) (Melleolides biosynthesis cluster protein PRO1) (P0DL13)
Organism: Armillaria gallica (Bulbous honey fungus) (Armillaria bulbosa)
Function: Delta(6)-protoilludene synthase, part of the gene cluster that mediates the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols. The first step in melleolides biosynthesis is performed by the delta(6)-protoilludene synthase PRO1 which catalyzes the cyclization of farnesyl diphosphate to protoilludene. The orsellinic acid synthase armB produces OA by condensing acetyl-CoA with 3 malonyl-CoA units in a three-round chain elongation reaction folowed by a C2-C7 ring closure (By similarity). ArmB further catalyzes the trans-esterification of OA to the various sesquiterpene alcohols resulting from the hydroxylation of protoilludene (By similarity). The melleolides cluster also includes 5 cytochrome P450 monooxygenases, 4 NAD(+)-dependent oxidoreductases, one flavin-dependent oxidoreductase, and one O-methyltransferase (By similarity). The cytochrome P450 monooxygenases may be involved in protoilludene hydroxylation to elaborate melleolides with multiple alcohol groups, such as melleolide D, which carries alcohol functionalities at C-4, C-5, C-10, and C-13 (By similarity). The role of the NAD(+)-dependent enzymes remains unknown (By similarity). Numerous melleolides, including arnamial, show 5'-O-methylation of the aromatic moiety which may be catalyzed by the methyltransferase encoded in the cluster (By similarity). The flavin-dependent oxidoreductase might represent the dehydrogenase yielding the aldehyde in position 1 of arnamial and other melleolides (By similarity). Finally, several halogenases, localized outside of the cluster, are able to catalyze the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product (By similarity).
Interaction partners:
Sequence:
MSQRIFLPDTLANWQWPRHLNPHYAEVKKASAAWAKSFRAFQTKAQEAFDRCDFNLLASFAYPLADEARLRSGCDLMNLFFVIDEYSDVATEEEVRAQKDIVMDAIRNTEKPRPAGEWIGGEVSRQFWDLAKKTASTQAQKRFIDTFDEYLESVVQQAADRNNSHVRGIESYLEVRRNTIGAKPSFALLEFDMQLPDEVINHPVIKELENSCIDMLCLGNDVVSYNLEQARDDDGHNIVTIAMNELRTDVAGAMIWVDEYHKQLESRFMENFKKVPRWGGPIDLQVARYCDGLGNWVRANDQWSFESERYFGKKGPEIIQRRWITLMPKMVSEELGPQIVDGSHL
Protein: Nucleoprotein (Nucleocapsid protein) (NP) (Protein N) (Q77M43)
Organism: Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)
Function: Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest.
Subcellular location: Virion {ECO:0000250|UniProtKB:P04851}. Host cytoplasm {ECO:0000250|UniProtKB:P04851}. Host nucleus {ECO:0000250|UniProtKB:P04851}.
Interaction partners:
Sequence:
MATLLRSLALFKRNKDKPPITSGSGGAIRGIKHIIIVPIPGDSSITTRSRLLDRLVRLIGNPDVSGPKLTGALIGILSLFVESPGQLIQRITDDPDVSIRLLEVVQSDQSQSGLTFASRGTNMEDEADQYFSHDDPISSDQSRFGWFGNKEISDIEVQDPEGFNMILGTILAQIWVLLAKAVTAPDTAADSELRRWIKYTQQRRVVGEFRLERKWLDVVRNRIAEDLSLRRFMVALILDIKRTPGNKPRIAEMICDIDTYIVEAGLASFILTIKFGIETMYPALGLHEFAGELSTLESLMNLYQQMGETAPYMVILENSIQNKFSAGSYPLLWSYAMGVGVELENSMGGLNFGRSYFDPAYFRLGQEMVRRSAGKVSSTLASELGITAEDARLVSEIAMHTTEDKISRAVGPRQAQVSFLHGDQSENELPRLGGKEDRRVKQSRGEARESYRETGPSRASDARAAHLPTGTPLDIDTATESSQDPQDSRRSADALLRLQAMAGISEEQGSDTDTPIVYNDRNLLD
Protein: Inositol monophosphatase (IMP) (IMPase) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase) (Q54U72)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P29218}.
Interaction partners:
- Inositol-3-phosphate synthase
- 3'
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Inositol oxygenase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Glucose-6-phosphate isomerase
- Uncharacterized protein
- ATP-dependent 6-phosphofructokinase
- DNA-directed RNA polymerases I, II, and III subunit rpabc2
- Multiple inositol polyphosphate phosphatase 1
Sequence:
MENITLDQYLQSAVDVVKEIGPMILKNYNSRSKQIEYKGAIDLVTDTDKAVEEHIIKTLTTKYPHTKILGEESTKDGIYNWGNEPTWVIDPIDGTTNFVHRFPLFCVSIALSINKEIVVACLYAPVLDELFTATKGGGAFLNGESISVSSVEHLSQSIISTNVGYDRSDKGIEFMLTNFKNILKDNVQALRFSGTAAWEMASVSCGRVDSFYEWGIHPWDIAAASLLITEAGGVVVDPSGGKCDMESRKVLCGNPNIVNKLSKLLIEKPTSN
Protein: Haloalkane dehalogenase (EC 3.8.1.5) (P59337)
Organism: Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
Function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
Interaction partners:
- S-
- Blr4874 protein
- Alcohol dehydrogenase
- Bll7981 protein
- alcohol dehydrogenase
- Probable alcohol dehydrogenase AdhA
- alcohol dehydrogenase
- alcohol dehydrogenase
- ExaA protein
- Blr8188 protein
Sequence:
MSKPIEIEIRRAPVLGSSMAYRETGAQDAPVVLFLHGNPTSSHIWRNILPLVSPVAHCIAPDLIGFGQSGKPDIAYRFFDHVRYLDAFIEQRGVTSAYLVAQDWGTALAFHLAARRPDFVRGLAFMEFIRPMPTWQDFHHTEVAEEQDHAEAARAVFRKFRTPGEGEAMILEANAFVERVLPGGIVRKLGDEEMAPYRTPFPTPESRRPVLAFPRELPIAGEPADVYEALQSAHAALAASSYPKLLFTGEPGALVSPEFAERFAASLTRCALIRLGAGLHYLQEDHADAIGRSVAGWIAGIEAVRPQLAA
Protein: Amino acid ABC transporter membrane protein (Q9I404)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429}. Cell membrane {ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU363032}.
Interaction partners:
- Amino acid ABC transporter ATP binding protein
- Amino acid ABC transporter membrane protein
- L-glutamate/L-aspartate-binding protein
- Glutathione hydrolase proenzyme
- Amino acid ABC transporter ATP binding protein
- Glutaminase-asparaginase
- L-arginine-binding protein
- Probable binding protein component of ABC transporter
- Probable ATP-binding component of ABC transporter
- Probable ATP-binding component of ABC transporter
Sequence:
MMDFSGIVPALPSLWEGMLMTLKLMVLGVLGGVALGTVLALMRLSHSKLLSNIAGFYVNYFRSIPLLLVITWFYFAVPFILRWITGEDTPVGAFTSCLVAFMMFEAAYYCEIVRAGIQAIPKGQMGAAQALGMTYGQTMRLVILPQAFRKMTPLLLQQSIILFQDTSLVYTVGLMDFLNSARSRGDIIGQANEFLIFAGLVYFVVSFTASFAVKRLQKRLTV
Protein: Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (Follitropin beta chain) (Q8QGF8)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU004069}.
Interaction partners:
- Glycoprotein hormones alpha chain
- Follicle-stimulating hormone receptor
- Gonadotropin-inhibitory hormone
- Type II GnRH receptor
- Prolactin
- G_PROTEIN_RECEP_F1_2 domain-containing protein
- Progonadoliberin-1
- Uncharacterized protein.
- Lutropin-choriogonadotropic hormone receptor
- Small ribosomal subunit protein mS26
Sequence:
MKTLNCYVLLFCWKAICCYSCELTNITIAVEREECELCITVNATWCSGYCFTRDPVYKYPPVSSVQQICTFKEVVYETVKIPGCGDHPESFYSYPVATECHCETCDTDSTDCTVRGLGPSYCSFSHNGSNQ
Protein: MPS-3 (MiRP K channel accessory Subunit) (Q56VR9)
Organism: Caenorhabditis elegans
Interaction partners:
- SUN domain-containing protein
- BTB domain-containing protein
- MinK-related peptide, potassium channel accessory subunit protein 4
- MiRP K channel accessory Subunit
Sequence:
MITPLPILFFLCIAYILLYIYKHPITPRNSRKKNVLLSLHSLSSLIHVAMFYFLLVQWSKADNPVLTHFQIFCLVIIGIGFLIILILIFSIFKSEMKSDSHARRFFHIWPLVHIALSTAYQLFTQIVISHWKTYQIPILYSSYATTVSVCIHLVLHSMAVFWKV
Protein: Transcription termination factor 4, mitochondrial (Mitochondrial transcription termination factor 4) (mTERF domain-containing protein 2) (Q8BVN4)
Organism: Mus musculus (Mouse)
Function: Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S (By similarity). Targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:21531335}.
Interaction partners:
- 5-cytosine rRNA methyltransferase NSUN4
- Mitochondrial ribosome-associated GTPase 1
- Mitochondrial assembly of ribosomal large subunit protein 1
- tRNA
- rRNA methyltransferase 2, mitochondrial
- Mitochondrial ribosome-associated GTPase 2
- DNA-directed RNA polymerase, mitochondrial
- Large ribosomal subunit protein mL62
- Transcription termination factor 1a, mitochondrial
- Large ribosomal subunit protein uL2m
Sequence:
MASLGRQVPEWHRLLALSWACLVRQTPHLREQKQMSPSLSCKLTTVPGRGSFQEFSSITPQKYMQEPENRTRLVQCLHEEQKPCVDPESLEPEKVIRSLQDMGFAEAHIHSLFSIQPSVHPQQLLGIVSELLLLGLNPEPVFNALKKNPQLLKLSSMQMKRRSSYLRKLGLGEGKLKRVLSVCPEVFTMHQRDIDRVVKVLREKCLFTAQHITDVLHRCPTVLQEDPNELEYKFQYAYFRMGLTHLDIVRTNFLQYSITKIKQRHIYLERLGRYQTPDKKGQTQIPNPSLRNILRVSEAEFLARTACSSVEEFQVFKKLLDQEEEEESESHASEEEEEEEEEEELL
Protein: Nitrilase 2 (EC 3.5.5.1) (P32962)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Can convert indole-3-acetonitrile to the plant hormone indole-3-acetic acid.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Tightly associated with the plasma membrane.
Interaction partners:
- Amidase 1
- Indole-3-acetaldehyde oxidase
- Indole-3-acetaldehyde oxidase
- Indoleacetaldoxime dehydratase
- Myrosinase 4
- Ferredoxin--nitrite reductase, chloroplastic
- Probable amidase At4g34880
- Glutamine synthetase, chloroplastic/mitochondrial
- Glutamine synthetase cytosolic isozyme 1-1
- Glutamine synthetase cytosolic isozyme 1-3
Sequence:
MSTSENTPFNGVASSTIVRATIVQASTVYNDTPATLEKANKFIVEAASKGSELVVFPEAFIGGYPRGFRFGLGVGVHNEEGRDEFRKYHASAIKVPGPEVEKLAELAGKNNVYLVMGAIEKDGYTLYCTALFFSPQGQFLGKHRKLMPTSLERCIWGQGDGSTIPVYDTPIGKLGAAICWENRMPLYRTALYAKGIELYCAPTADGSKEWQSSMLHIAIEGGCFVLSACQFCLRKDFPDHPDYLFTDWYDDKEPDSIVSQGGSVIISPLGQVLAGPNFESEGLITADLDLGDVARAKLYFDSVGHYSRPDVLHLTVNEHPKKPVTFISKVEKAEDDSNK
Protein: Calcium-dependent protein kinase 4 (EC 2.7.11.1) (Calmodulin-domain protein kinase CDPK isoform 4) (Q38869)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger. Functions as regulator of the calcium-mediated abscisic acid (ABA) signaling pathway. Phosphorylates ABA-responsive transcription factors ABF1 and ABF4 in vitro. Phosphorylates the nuclear zinc finger Di19 in vitro.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12913141}. Nucleus {ECO:0000269|PubMed:12913141}.
Interaction partners:
- Respiratory burst oxidase homolog protein D
- ABSCISIC ACID-INSENSITIVE 5-like protein 4
- ABSCISIC ACID-INSENSITIVE 5-like protein 7
- Respiratory burst oxidase homolog protein F
- 17.6 kDa class II heat shock protein
- Guard cell S-type anion channel SLAC1
- Calcineurin B-like protein 1
- Respiratory burst oxidase homolog protein B
Sequence:
MEKPNPRRPSNSVLPYETPRLRDHYLLGKKLGQGQFGTTYLCTEKSSSANYACKSIPKRKLVCREDYEDVWREIQIMHHLSEHPNVVRIKGTYEDSVFVHIVMEVCEGGELFDRIVSKGCFSEREAAKLIKTILGVVEACHSLGVMHRDLKPENFLFDSPSDDAKLKATDFGLSVFYKPGQYLYDVVGSPYYVAPEVLKKCYGPEIDVWSAGVILYILLSGVPPFWAETESGIFRQILQGKIDFKSDPWPTISEGAKDLIYKMLDRSPKKRISAHEALCHPWIVDEHAAPDKPLDPAVLSRLKQFSQMNKIKKMALRVIAERLSEEEIGGLKELFKMIDTDNSGTITFEELKAGLKRVGSELMESEIKSLMDAADIDNSGTIDYGEFLAATLHINKMEREENLVVAFSYFDKDGSGYITIDELQQACTEFGLCDTPLDDMIKEIDLDNDGKIDFSEFTAMMKKGDGVGRSRTMRNNLNFNIAEAFGVEDTSSTAKSDDSPK
Protein: PID domain-containing protein (F1LIN5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDRLRRSLRLPKKRRDRSHDRHLSPDVTGGSKTEQWQPDEGAVRTGTCCFNVKYLGSVEVYESRGMQVCEGALKSLKASRRKPVKAVLYVSGDGLRVVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLATKETGERLSHAVGCAFSICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFHPNWEDNTSEGTSTQNPSNSRSNLAYQSFRKHVSIEDRYLDPQSVIINEVPASNHMDEIRRISKPRPTGNPALFLRQGSLRAPPDMPSSSDQFKRNMSLRTVSNNPTERSPEKKSFGTQLYNEPIYEGDEDPLGLGITPPVVTKTSGSLSNNGLDGINLNWKSIPAPVHQMQQHNANGDFVAAWPQNTIEKPTVGPLDKLQKQFEDIKLISISSGENTPTTRSKADEWLDDVLRVSMSMSPTSPSSDPPSTSSYSVLPKSGPPPAHAPPPLPVRQAVSNGSPSIYQQQLQQANSTRNSPAGINWNSSPNPMKISQPPAKPVDPFDVQWSRLAVNNTH
Protein: Uncharacterized protein C11G11.07 (Q9USZ2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Exportin-T
- Uncharacterized protein C328.01c
- Pre-mRNA-splicing factor srp2
- Importin subunit beta-2
- Exportin-1
- GTP-binding nuclear protein spi1
- Succinate--CoA ligase subunit alpha, mitochondrial
- Pre-mRNA-splicing factor srp1
- Importin subunit beta-3
- Ran GTPase-activating protein 1
Sequence:
METLLSALATLYANTDREQKLQANNYLEEFQKSPAAWQICFSILNQDDSSIEAKLFAAQTLRQKIVYDFHQLPKETHIEFRNSLLQLFLAAKDSPRPLLVSLAVCMAAIALHMTEWHNVIADVFQACSSKDPSGRCVLQFLSVLPEEASDPRKTSLSWEELCIRVDELLRDNGPAVLELLVQYVDAVRASGSPSSADLGLVLTSLISWLREIPLDKVMASPLIELAFRSLDDDLLLEDAVEFLCALFNETKDVDETTDAILMLYPRLLELQPKLIAACDDPETFRALGRLFAEAGEAWVVLIARMPNDFLPLVNCIAQVAANDTELEAIKFTFAFWWDLKQMVELDVYAEARQLFAPIYLELVRIIVRHLHYPRTEDLAINEQMASNEVLFEDRDAEDRFRSFRHEMGDVLKDCCVVAGVSSCLVQISSQLIKVLKIKESGLPYYWQDVEAPLFALRAIGRMVPANEDQVIGSLFQILPQLPENNKVRYAATLFLGRYTEWTAQHSEFLELQLNYISAGFEVANKEVQSAAAQALKHFCYDCREQLVGHLSQLHMFYLNAKTYLAPDPLMEVAQGLAHIVDIQPVANVYQSVHSFLAPSLQSILLAQVKLNPTQAELEALADNIDIVTIFLSLVHPPSPAGELHPIVRLFQDIWPILSRTLDTFSDVLICERISKLLKNFIYTFKEKAIVTLPVITEALIKGFEKTQYGCFLWVSGACVRQFGVPEMDEQTLSAVWSFVGKQCTNMFYYMSNKNPKEIPDVIDDFFRLMMDALLANPQMVLESQMLESLIQAAMMSLQLEQQEPLQTVLNFLQDLLAFALHTPPYSLIEPLPDSLLKSLADLLLKNSQELYIILFNGMVFTFPRDNISDASAVLIPLIRLVFAADPSLCIKYMSNVLDQLPAMTIGQEEREKFLANFSKHCTSSEMPRLRAHLQDWTAMYRRRVLTPRAKLISDD
Protein: Histone deacetylase 9 (AtHDAC9) (EC 3.5.1.98) (Q8H0W2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:28663238}. Note=Localized to the cytosol when in complex with farnesylated ASG2. {ECO:0000269|PubMed:28663238}.
Interaction partners:
- WD40 repeat-containing protein HOS15
- Histone deacetylase complex subunit SAP18
- High mobility group B protein 9
- High mobility group B protein 10
- High mobility group B protein 15
- Putative high mobility group B protein 11
- Histone-binding protein MSI1
- AT-hook motif nuclear-localized protein 22
- Histone deacetylase HDT3
- Paired amphipathic helix protein Sin3-like 1
Sequence:
MRSKDKISYFYDGDVGSVYFGPNHPMKPHRLCMTHHLILAYGLHSKMEVYRPHKAYPIEMAQFHSPDYVEFLQRINPENQNLFPNEMARYNLGEDCPVFEDLFEFCQLYAGGTIDAARRLNNKLCDIAINWAGGLHHAKKCDASGFCYINDLVLGILELLKHHPRVLYIDIDVHHGDGVEEAFYFTDRVMTVSFHKFGDKFFPGTGDVKEIGEREGKFYAINVPLKDGIDDSSFNRLFRTIISKVVEIYQPGAIVLQCGADSLARDRLGCFNLSIDGHAECVKFVKKFNLPLLVTGGGGYTKENVARCWTVETGILLDTELPNEIPENDYIKYFAPDFSLKIPGGHIENLNTKSYISSIKVQILENLRYIQHAPSVQMQEVPPDFYIPDFDEDEQNPDVRADQRSRDKQIQRDDEYFDGDNDNDAS
Protein: Prune (Q629J6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGNESCDLDSAVSAVTLAFVYAQRHREHDYVPILNIPRRDYPLKTEVGHLFVKCGIAEPVLLFRDDIPREVVQDVNVILVDHHVSPLAPNVTEILDHRPLEDSSPSFKQLPTLCQLDIDASVGSCATLVAQRYLAEDQPRSTSVAQLLHATIVLDTINFAPAAKRYGPKDEAMVQKLESELNRKDAQRSSLFDELVAARADISKLTLTEVLRKDMKVLQTDRQVVPLAGMPILVRDFVEKSGAEKAVREFGVESNLLVILGMYVSPADGQVQRDLALISLSGQGQFVQRVQQALMESNDPKLELRPHEVDTRFMGGCFLRQHNVQATRKHILPIVKRALLEWEADHACDCDEVYFFKEKPQLGLS
Protein: Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Abnormal wing disks protein) (Killer of prune protein) (P08879)
Organism: Drosophila melanogaster (Fruit fly)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:2175255}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:2175255}. Note=Microtubule-associated.
Interaction partners:
- Thymidylate kinase
- Inosine triphosphate pyrophosphatase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- CTP synthase
- Adenylate kinase 1
- Small ribosomal subunit protein bS16m
- Guanosine-3',5'-bis
- Ribonucleoside-diphosphate reductase large subunit
- UMP-CMP kinase
- GTP:AMP phosphotransferase, mitochondrial
Sequence:
MAANKERTFIMVKPDGVQRGLVGKIIERFEQKGFKLVALKFTWASKELLEKHYADLSARPFFPGLVNYMNSGPVVPMVWEGLNVVKTGRQMLGATNPADSLPGTIRGDFCIQVGRNIIHGSDAVESAEKEIALWFNEKELVTWTPAAKDWIYE
Protein: Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (P62914)
Organism: Rattus norvegicus (Rat)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9CXW4}. Cytoplasm {ECO:0000250|UniProtKB:Q9CXW4}.
Interaction partners:
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL18
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein uL13
- Ubiquitin-ribosomal protein eL40 fusion protein
- Small ribosomal subunit protein uS7
Sequence:
MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK
Protein: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (Q93WB8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
- non-specific serine/threonine protein kinase
- DExH-box ATP-dependent RNA helicase DExH4, chloroplastic
- AT4g33380/F17M5_140
- Insulin-degrading enzyme-like 1, peroxisomal
- F-box protein SKIP16
Sequence:
MKKIQIGAVALLVFLSVASLFEIGLASPNTVPAFLWSPHLQSANGELDEAVNYQVMSAKDLVGSVFTQGGWSNFLCSEKKLEQPVDVALVFIGRELLSSDVSSKRNSDPALVNTLNNLFTASNFSLAFPYIAAPEEERMENLLLSGLKEACPNNVGVSNIVFSDSCFVEDGTIQKLSDLQSFKDHLLARRETRKEGETDLVVLCSEGSESNSQAGQSHSERESFLELVSSVEQSGSKYTALYVSDPYWYTSYKTLQRFLAETAKGNSTPEIATGCDELCKFKSSLLEGILVGIVFLLILISGLCCMAGIDTPTRFETPQDS
Protein: Sulfurtransferase TusE (EC 2.8.1.-) (tRNA 2-thiouridine synthesizing protein E) (P0AB18)
Organism: Escherichia coli (strain K12)
Function: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Sulfurtransferase TusD
- Protein TusB
- tRNA-specific 2-thiouridylase MnmA
- Protein TusC
- Sulfur carrier protein TusA
- tRNA sulfurtransferase
- Cysteine desulfurase IscS
- Modulator of FtsH protease YccA
- tRNA-cytidine
- Sulfur carrier protein ThiS
Sequence:
MLIFEGKEIETDTEGYLKESSQWSEPLAVVIAENEGISLSPEHWEVVRFVRDFYLEFNTSPAIRMLVKAMANKFGEEKGNSRYLYRLFPKGPAKQATKIAGLPKPVKCI
Protein: Photosystem II reaction center protein L (PSII-L) (Q2LIM7)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Plastid, chloroplast thylakoid membrane {ECO:0000256|HAMAP-Rule:MF_01317}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01317}.
Interaction partners:
Sequence:
MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
Protein: Beta-1,4 N-acetylgalactosaminyltransferase 2 (EC 2.4.1.-) (Q09199)
Organism: Mus musculus (Mouse)
Function: Responsible for synthesis of murine T-lymphocyte CT antigen. Can transfer N-acetylgalactosamine moiety from UDP-GalNAc to the low molecular weight acceptor 3'-sialyl-N-acetyllactosamine, to form a non-reducing terminal tetrasaccharide Sda blood group structure.
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q8NHY0}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Cytidine monophosphate-N-acetylneuraminic acid hydroxylase
- Uromodulin
- N-acetyllactosaminide alpha-1,3-galactosyltransferase
Sequence:
MTSSVSFASFRFPWLLKTFVLMVGLATVAFMVRKVSLTTDFSTFKPKFPEPARVDPVLKLLPEEHLRKLFTYSDIWLFPKNQCDCNSGKLRMKYKFQDAYNQKDLPAVNARRQAEFEHFQRREGLPRPPPLLAPPNLPFGYPVHGVEVMPLHTILIPGLQYEGPDAPVYEVILKASLGTLNTLADVPDDEVQGRGQRQLTISTRHRKVLNFILQHVTYTSTEYYLHKVDTVSMEYESSVAKFPVTIKQQTVPKLYDPGPERKIRNLVTIATKTFLRPHKLKILLQSIRKYYPDITVIVADDSKEPLEINDDYVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFSDKTKIEVLVDVLEKTELDVVGGSVQGNTYQFRLLYEQTKNGSCLHQRWGSFQALDGFPGCTLTSGVVNFFLAHTEQLRRVGFDPILQRVAHGEFFIDGLGRLLVGSCPGVIINHQVRTPPKDPKLAALEKTYDKYRANTNSVIQFKVALQYFKNHLYCST