wanglab/gogpt-training-data huggingface dataset:
Protein: Elloramycin glycosyltransferase ElmGT (EC 2.4.1.331) (Q9F2F9)
Organism: Streptomyces olivaceus
Function: Glycosyltransferase that transfers an L-rhamnose moiety from dTDP-L-rhamnose to the elloramycin aglycone 8-demethyl-tetracenomycin C (8DMTC) in elloramycin biosynthesis, an antitumor polyketide. Possesses donor substrate flexibility: able to transfer at least 11 different sugars to 8DMTC, such as NDP-D-glucose, as well as NDP-L-digitoxose, including both L- and D-isomeric forms of some sugars.
Interaction partners:
Sequence:
MRVLAVATPALGHLFPAVPLLWALRARGDEVLVVTGGDALRVAEAGLPVVDALPGETLTTLFGAYQETDPAFFVALRRSPMTTLRDLAPVLAYLAGRLLEPARRAAERWRPDAILATHGQAAGAVVAAEHGIPLVEHGFGFVRSDGAQEAVRQLLAERLGPAGSEPPPERYFLDIAVPSMTSAIEGMSLRAVPYNGGAVLPLSGASVGGRPPRPRVLVTAGTQLLHTHGAGALAWLPEVAAGHEAEFLLAAGGADLRDLGRLPPHVRVLDWTPLATVLPTCSAVVHHGGSGTTLAALAAGVPQLVSPALADNHINARAVADRGAGLETAVPDATTLTALLREPAFAKAAREVADELRSLPAPADVAARLHTAFGLPTTQGDA
Protein: C2H2-type domain-containing protein (Q38F66)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MRHVGFAHHTRLNRIGRCAFPLIFQHIHHFPMVLMAPSAALRSYVTSEIPQHVAGLEEMLPNSLRCPECGKHFMSATNLLYHRRTRHMITIISSAQEQLDRLREENARLRAELQQAHMQHRQTTPNQQPMSGTTAGELDKTQRIFPAAVPEGKALGISMAEVHNLREHPFRVGTGCSGVRCVGVVSDDVEVGHLGRHEGGTESGLEVLQFTLKLEGYRQRRTGRLMMYNNLVTVRLMSPQYRVEKGDVVLVIGNYGLHRSFDLISKQSMENCVLEAGYIGLLKRGSQAGNSEYTREDV
Protein: Pfmc-2TM Maurer's cleft two transmembrane protein (Q8IIY8)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MFFYIYKIYIFTIILCASNLFNDNGVENGTYKSSYHNGGIQFRMLAQNNTNKKSNGNTLTNILLKDKGEKGGKKKNPDDQISDLVNLVDNMNITQEKKNEIKNLTLKYMNSDDIKEKNKSINELKKYSNNEECKEHMDNYLMYLRMQNDIKCLKRKNFWNNIWINSINFFVIIIMIACVVVGLIEASSISYPLCIFPVFMLYMLVRFFPDMKMGFKKIKETCTNFFQKKKK
Protein: Vacuolar protein sorting-associated protein 29 (Q382A8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Vacuolar protein sorting-associated protein 35
- Vacuolar sorting-associated protein-like, putative
- Rab-GAP TBC domain-containing protein
- VPS9 domain-containing protein
- Inosine triphosphate pyrophosphatase
- PX domain-containing protein
- Phosphoinositide-binding protein, putative
- PX domain-containing protein
Sequence:
MVLVLVVGDLHVPQRAASIPKVFTQMFTPGRIQLVLITGNVGCREMYDYFRSIVPDVYCAKGEFDSCWWPNVNSKHASDTDKLLQDTHVINVESLRIGLIHGHQAIPCGDRDMLAMLQRKLDVDVLVSGATHNNKVFEFGGHLFVNPGSITGAFTTRRLDVVPTFVLLDIQDKKVTSFSYAYAPGEGVGGEDFKIKRKTWIKDEEEEGEETQKPPASAVPPPPPPE
Protein: Nematode cuticle collagen N-terminal domain-containing protein (Q18345)
Organism: Caenorhabditis elegans
Interaction partners:
- Nematode cuticle collagen N-terminal domain-containing protein
- Col_cuticle_N domain-containing protein
- DUF281 domain-containing protein
- Cuticle collagen dpy-2
- DumPY: shorter than wild-type
- Cuticle collagen sqt-1
- Protein qua-1
- Nematode cuticle collagen N-terminal domain-containing protein
- Cuticle collagen lon-3
- Cuticle collagen rol-6
Sequence:
MRDFYDVAVASIVLSTFTLVVAVFSVPMLFHKSDNVLLEISSFSDGIKAKSDLVWNELMEIKQGDAVPGIQYFSRKARSNWMGGAFCKGCFLLSCPQGPPGPPGAPGPDGQPGDAGRQGRSGDDGFDIQPESEPELPCVICPAGPPGPRGAQGERGMTGNPGMAGMQGTIGMEGVDGGPGLPGPPGPKGERGPLGPYGPPGDTVVAGVGIKGPLGPPGPQGMKGPPGPSGKGSNQPGQPGQPGDIGGIGKTGKMGGYGMEGPAGPPGDPGMPASYCPSDCGVQPILTEMFPTPFTPTAGYSNMQRPAAPSRPLAHPEYADGSAPAHLPHSGASDSAAASEVDAPAPHQHRKSHRLRPSHQQQYGDEQNNAVADAGRSVNAPEYGDGSAPSHMPSHRAHHHPNSASQNYVDPERGSDTAAADAYANRMHDFQDFERKWRKKLLQRRLRMMKRQ
Protein: Keratin-associated protein 5-3 (Keratin-associated protein 5-9) (Keratin-associated protein 5.3) (Keratin-associated protein 5.9) (UHS KerB-like) (Ultrahigh sulfur keratin-associated protein 5.3) (Q6L8H2)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Interaction partners:
Sequence:
MGCSGCSGGCGSSCGGCGSSCGGCGSGYGGCGSGCCVPVCCCKPVCCCVPACSCSSCGSCGGSKGVCGSCGGCKGGCGSCGGSKGGCGSSCCVPVCCSSSCGSCGGSKGVCGFRGGSKGGCGSCGCSQCSCYKPCCCSSGCGSSCCQSSCCKPSCSQSSCCKPCCSQSSCCKPCCCSSGCGSSCCQSSCCKPCCSQSSCCKPCCCSSGCGSSCCQSSCCKPCSSQSSCCVPICCQCKI
Protein: Vitamin D3 receptor B (VDR-B) (1,25-dihydroxyvitamin D3 receptor B) (Nuclear receptor subfamily 1 group I member 1-B) (Q1L673)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P11473, ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250|UniProtKB:P11473}. Note=Localizes mainly to the nucleus. Translocated into the nucleus via both ligand-dependent and ligand-independent pathways; ligand-independent nuclear translocation is mediated by IPO4. {ECO:0000250|UniProtKB:P11473}.
Interaction partners:
- Cytochrome P450, family 27, subfamily B, polypeptide 1
- NR LBD domain-containing protein.
- Sodium calcium exchanger 1n
- Cytochrome P450, family 24, subfamily A, polypeptide 1
Sequence:
MESAVSTSTQVPDEFDRNVPRICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFNGSCTITKDNRRHCQACRLKRCLDIGMMKEFILTDEEVQRKKELIQRRKDEEAHREAQKPRLSDEQRNIIDTLVDAHHKTYDDSYSDFSRFRPPVREGPVTRSASRAASLHSLSDASSDSFSHSPESGDRKMNLSNLLMMYQEQGLSSSPDSKEEDGSSLSMLPHLADLVSYSIQKVIGFAKMIPGFRELTAEDQIALLKSSAIEVIMLRSNQSFSLEDMSWSCGGPEFKYCVNDVTKAGHTLELLEPLVKFQVGLKKLNLHEEEHVLLMAICLLSPDRPGVQDHVRVEALQDKVSEVLQAYIRAHHPGGRLLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGGQVT
Protein: ERBB receptor feedback inhibitor 1 (Gene 33 polypeptide) (Mitogen-inducible gene 6 protein homolog) (MIG-6) (Receptor-associated late transducer) (RALT) (P05432)
Organism: Rattus norvegicus (Rat)
Function: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MSTAGVAAQDIRVPLKTGFLHNGQALGNMKTCWGSRNEFEKNFLNIDPITMAYNLNSPAPEHLTTLGCASPSAPGSGHFFAERGPSPKSSLPPLVIPPSESSGQREEDQVLCGFKKLSVNGVCASTPPLTPIQSCSSPFPCAAPCDRSSRPLPPLPISEDPSLDEADCEVEFLTSADTDFLLEDCVPSDFKYDVPGRRSFRGCGQINYAYFDSPTVSVADLSCASDQNRVVPDPNPPPPQSHRRLRRSHSGPAGSFNKPAIRISSCTHRASPSSDEDKPEIPPRVPIPPRPAKPDYRRWSAEVTSNTYSDEDRPPKVPPREPLSRSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQSSEGSAKAPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKYFREAEEANPSTQIQPLPAACGMVSATDKLASRMKMDVGGHGKRKHLSYVVSP
Protein: Nitrogenase molybdenum-iron protein beta chain (EC 1.18.6.1) (Dinitrogenase) (Nitrogenase component I) (P07329)
Organism: Azotobacter vinelandii
Function: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
Interaction partners:
Sequence:
MSQQVDKIKASYPLFLDQDYKDMLAKKRDGFEEKYPQDKIDEVFQWTTTKEYQELNFQREALTVNPAKACQPLGAVLCALGFEKTMPYVHGSQGCVAYFRSYFNRHFREPVSCVSDSMTEDAAVFGGQQNMKDGLQNCKATYKPDMIAVSTTCMAEVIGDDLNAFINNSKKEGFIPDEFPVPFAHTPSFVGSHVTGWDNMFEGIARYFTLKSMDDKVVGSNKKINIVPGFETYLGNFRVIKRMLSEMGVGYSLLSDPEEVLDTPADGQFRMYAGGTTQEEMKDAPNALNTVLLQPWHLEKTKKFVEGTWKHEVPKLNIPMGLDWTDEFLMKVSEISGQPIPASLTKERGRLVDMMTDSHTWLHGKRFALWGDPDFVMGLVKFLLELGCEPVHILCHNGNKRWKKAVDAILAASPYGKNATVYIGKDLWHLRSLVFTDKPDFMIGNSYGKFIQRDTLHKGKEFEVPLIRIGFPIFDRHHLHRSTTLGYEGAMQILTTLVNSILERLDEETRGMQATDYNHDLVR
Protein: Pyruvate kinase 1, cytosolic (OsPK1) (EC 2.7.1.40) (Q2RAK2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Key regulatory enzyme of the glycolytic pathway that catalyzes the final step of glycolysis, converting ADP and phosphoenolpyruvate (PEP) to ATP and pyruvate by essentially irreversible transphosphorylation. Is critical for plant growth and development.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:21805151}.
Interaction partners:
- Os06g0258900 protein
- phosphopyruvate hydratase
- Inosine triphosphate pyrophosphatase
- phosphopyruvate hydratase
- Enolase
- phosphopyruvate hydratase
- Os01g0196600 protein.
- Os01g0926300 protein
- phosphopyruvate hydratase
- Os08g0154300 protein.
Sequence:
MHSTNLLLEEPIRMASILEPSKPSFFPAMTKIVGTLGPKSRAVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKLAIKSTKKLCAVMLDTVGPELQVVNKSEAAISLEANGTVVLTPDQGQEASSELLPINFSGLAKALKPGATIFVGQYLFTGSETTSVWLEVSEVKGDDVVCVIKNSATLAGSLFTLHCSQIHIDLPTLSDEDKEVIRRWGAPNKIDFLSLSYTRHAEDVRQAREFLSKLGDLSQTQIFAKIENVEGLNHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVVTRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKYVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLRWSFTGAFEARQSLIVRGLFPMLADPRHPAESTSATNESVLKVALDHGKASGVIKSHDRVVVCQKVGDSSVVKIIELDD
Protein: Sulfur acceptor protein CsdE (P0AGF2)
Organism: Escherichia coli (strain K12)
Function: Stimulates the cysteine desulfurase activity of CsdA. Contains a cysteine residue (Cys-61) that acts to accept sulfur liberated via the desulfurase activity of CsdA. May be able to transfer sulfur to TcdA/CsdL. Seems to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine. Does not appear to participate in Fe/S biogenesis.
Interaction partners:
- Cysteine desulfurase CsdA
- Cysteine desulfurase
- tRNA threonylcarbamoyladenosine dehydratase
- Sulfur carrier protein TusA
- Iron-sulfur cluster assembly protein SufB
- Antitoxin MazE
- Ribosomal RNA large subunit methyltransferase M
- Iron-sulfur cluster assembly scaffold protein IscU
- UPF0382 inner membrane protein YgdD
- tRNA sulfurtransferase
Sequence:
MTNPQFAGHPFGTTVTAETLRNTFAPLTQWEDKYRQLIMLGKQLPALPDELKAQAKEIAGCENRVWLGYTVAENGKMHFFGDSEGRIVRGLLAVLLTAVEGKTAAELQAQSPLALFDELGLRAQLSASRSQGLNALSEAIIAATKQV
Protein: LD23292p (Macroglobulin complement-related) (Q9VLT3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Transferrin 2
- Neurexin-4
- Contactin
Sequence:
MMWHLLRALLVVAAVLDALQPAVGQNDNYYNPNQNQQNPQQPLLPNQQWGNNPQTNQYSNNNQNFGQTNPSDRPPYRTDSGSYNDIAGQDDYNKRVGGGYQDNEEPSLTRGKSSYNIKATFLESLHSREPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKGVILVNDRETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFFVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTYLLNICEVCGSSQCPYCSIYNMGWRASMSMSLLFFSVFIYLLRSRTHLVLNMMQLLT
Protein: Importin subunit alpha (A0A060YJS5)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Importin N-terminal domain-containing protein
- Importin N-terminal domain-containing protein
- Exportin-2
- Exportin-2
- Exportin-2 C-terminal domain-containing protein
- Nuclear cap-binding protein subunit 2
- Ran-specific GTPase-activating protein
- Ran-specific GTPase-activating protein
- Nuclear pore complex NUP2/50/61 domain-containing protein
- Exosome complex component 10
Sequence:
MPTTSATDDRLNKFKNKGKEPSKLRERRIAECVELRKAAKNENFLKRRNITTLPEDAVQSPELNTDNHEVTVITIEEVVGHVNSDCKERQTRGCQAARKLLSRECNPPLKEIVEAGLLSRFVEFLGRDDDPSLQFEAAWALTNIASGTSWHTQQVVEHGAVPAFISLLASPMLHISEQAVWALGNIAGDGPAYRDTLIECNVIPALLSRITPDTPVGYLRNLTWTLSNLCRNKNPFPPLSAVQQVLPSLIQLLHLSDQDILSDACWAVSYLTDGANDRIDIVVQTGIVPRLVSLMGFEALTVVTPALRSIGNIVSGSDIQTQVAIDAGVLSVLPSLMRHSKPSVQKEATWAVSNIAAGPAQQIQQLLTCGLLPPLIDLLRNGDFKTQREAVWAITNFTSGGTVEQVIQLVQSGGLEAILNLLTVKDSKTILVILDAINNLFMAAEKMGETDKLCLLVEELGGLDKIEMLQNHENDTVYRTAQALIEKFFTDEEAEGLQTEATDTTFAFKTQDVQKTFRF
Protein: arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (Q386W0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- glutamine--tRNA ligase
- Tyrosyl/methionyl-tRNA synthetase, putative
- isoleucine--tRNA ligase
- glutamate--tRNA ligase
- proline--tRNA ligase
- leucine--tRNA ligase
- methionine--tRNA ligase
- Tyrosyl-tRNA synthetase, putative
- Lysine--tRNA ligase
- Lysine--tRNA ligase
Sequence:
MAKYIAGPNVELSLKEIVHRAIKRAFPSINPPEILITLGKTTEYQCNNAMGLVKLLSSASPPIKTSPALVGEELKKNLEENDMIESFEPTPQGFINITIKPMWVAGTVGKVLREGIRPPNLPKQKVLVDFSSPNIAKEMHVGHLRSTIIGEAICRLFEFCQYEVHRINHIGDWGTAFGMLILFLRRKHPNFTEEVPNISDLTTFYREAKKCFDEDAEFKEQARLQVVKLQALEEESMKAWKIICDISRKEFLQIYERLNVTIEERGESFYNPLIPEVLKLLDEAGKLVESNGAKITVLSDKKSISALDAKDMAKLAAPHLLWAGKDTRVEFHPNMITAMREVGVLKGEEGNETVALSKKDAKPLKNFDIRTDVDKLVSLLQPLFKNKMSPLFREVFEAAGIVDGENITIPRFSFPLMIVKSDGGYTYDTTDVATMYHRFVLEKMDRVVYCTDVGQYEHLRMCADLAKDMGWMDRGTWSHAGFGLVTGADGKKIKTRSGESAKLKDLLDEAVERSRAILEEREKGDRAQGHTKEDIDELSKKIGIGAVKYFDLKQSRLNDYAFSYEKMLDLSGNTAVFLLYQYARLCSIERKCGVDREQFLSSEVVIETPQEKKLALCVLRMDSVVIRTVDDLLLHHLTDFAYELVSCFSDFFQNCKVIGHEQQNSRLCLVELTRLTLKQVLDILNIDVAEKI
Protein: T3SS secreted effector EspJ (Q8XB62)
Organism: Escherichia coli O157:H7
Interaction partners:
- Secreted effector protein EspF
- T3SS secreted effector NleC
- Protein-arginine N-acetylglucosaminyltransferase NleB1
- T3SS secreted effector NleA/EspI
- EspB
- EspF
Sequence:
MSIIKNCLSLINNALNIQKTSYSLTKMEQAGKLLNRKITPENTPPMLLSYRNADLTQEKNITERVLSIFKIKRDFVAVRIQNNQFTDLKNKKIQGHQNTVASVMDWYNPQKNALGITMGTPRKSADIAKEEHRNALNFMIMEKNTFHEKILNSNDNLQKSYSKTEDSSWVAASVGSLLDKGAKVYPDTSCSLRLGEPFIFTLPESVRVDVDIYPLKK
Protein: Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) (Q6P0Q8)
Organism: Homo sapiens (Human)
Function: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12117771}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to the sub-membranous area on interaction with CDHR2.
Interaction partners:
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Beta-2-syntrophin
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
- TNF receptor-associated factor 6
Sequence:
MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPEGKEQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPDASGDRRQDVPCRGCPLTQKSEPSLRRGQEPGGHQKHRDLALVPDELLKQT
Protein: Plant cysteine oxidase 2 (AtPCO2) (EC 1.13.11.20) (Hypoxia-responsive unknown protein 43) (Q8LGJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the oxidation of N-terminal cysteine residues (N-Cys), thus preparing the protein for N-end rule pathway-mediated proteasomal degradation, upstream of the N-end rule enzymes ATE1, ATE2 and PRT6. Controls the preparation of the group VII ethylene response factor (ERF-VII) proteins for degradation via the 26S proteasome N-end rule pathway. Acts as an oxygen sensor that controls the stability of ERF-VII proteins, which are stabilized in flooding-induced hypoxia, and regulate transcriptional adaptation to these adverse conditions (Probable). Not active on Cys located inside or at the C-terminus of a peptide. Acts redundantly with PCO1 to repress the anaerobic response.
Subcellular location: Nucleus {ECO:0000269|PubMed:24599061}. Cytoplasm {ECO:0000269|PubMed:24599061}.
Interaction partners:
- Rhodanese-like domain-containing protein 17
- At5g66985
- E3 ubiquitin-protein ligase PRT6
- At5g44730
- Sequence-specific DNA binding transcription factor
- Ethylene-responsive transcription factor RAP2-12
- Arginyl-tRNA--protein transferase 2
- LOB domain-containing protein 41
- AT4g27450/F27G19_50
Sequence:
MGTDTVMSGRVRKDLSKTNPNGNIPENRSNSRKKIQRRSKKTLICPVQKLFDTCKKVFADGKSGTVPSQENIEMLRAVLDEIKPEDVGVNPKMSYFRSTVTGRSPLVTYLHIYACHRFSICIFCLPPSGVIPLHNHPEMTVFSKLLFGTMHIKSYDWVPDSPQPSSDTRLAKVKVDSDFTAPCDTSILYPADGGNMHCFTAKTACAVLDVIGPPYSDPAGRHCTYYFDYPFSSFSVDGVVVAEEEKEGYAWLKEREEKPEDLTVTALMYSGPTIKE
Protein: Villidin (Q8WQ85)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May function as a linker between membranes and the actin cytoskeleton.
Subcellular location: Membrane {ECO:0000269|PubMed:12857859}; Peripheral membrane protein {ECO:0000269|PubMed:12857859}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12857859}. Note=Associated with membranes and the cytoskeleton.
Interaction partners:
Sequence:
MEYKSIEKSIVRESKVRNVFSKVCKKELFYTNLKVNSASEELLKSSKSLFAYPSSIGGGSCLSITKLSNHGKVPDTPFCIKGHTDPISCFEFSNFNDYVIATGSRDCTIKIWEVPEEGLIKDNLVTPLITLPKQQKRVTGVYFHPSVDSLFMSSTLDYTLDIWDLSSTGEQSSVIQKLTGHEDLIMSVGWNTWSGGDKLATSSRDKKMRLYDPRSQSTPIQTISTHEGAQGFKLCWADSNGLELICTVGANKSAQRQLYLWDPRQLQSSQPLVSKDVTTDSSILSPYYDFGTNMVYLGGKGDGIYYYEIEKNNAHHIGKATFGNVTQSAITLLPKSVVDVNICEIDRFLRLTAANSVEMVSFMCPRKSQLFQEDIFPPCPSGDPTTDCSLWFADKQLKVIPHTISMKPDGVQSIYEVSEEEGGKSKEKDKLEQLSKLSIGNSGSGGGGGDGDGNGGDSPFITEGIVKQEIEGWLFNSYENRYLKIVKDKIYCFLNEDSAQAIWDSPVLNIKYVDIYDEDENTSGEEWSLRFNIILLNGKEHRMECSTVKQRDAWCQSINAYREMKQQVDQSVVSPTMGEFHLVNTTPVAPSPMVISENKNALQKFSVPSPKEQQQQQQQGSESPNSTTPKSSTPTQTRHHSVLSRNPSYTSLKSSGGFSKPSPSSSTSTPPSTFASPLSIAQTSSTTTTTTTTTTTTSSSSTPPPLRANNSTSSTPLNSSTGIKQSDIVIEGNLTELIPGLLWNSNTEKWYVVSEGMLYSYKNKSLKQLDPLETIHLEKAISAHKTKEIFTIQGFSFQLSTPNRIIHLLAKTKEERGSWLSVLRQNLKSSGETKPKSVLTRASTMDELISSPMSDDESNTNEGGVEEEEEEQPLEGQLSRKLPGIFSMWGQCFVALLAEDLFVSRNKLSTTPELRIQLSSISLIKKISPNEFTLYDSMNQVVCNFRTIAPTAEFDDCTRWIDGLEAARKRSIDIIKMFGINEKEVLSPLPSSSSIPSSGSNGNLLDPSADDLTRYLDLTAIKNGKQKILIQVKGKRKIRVRMVKLSTSSLNCHNSFILDAGPRIFVWAGSKTSRVNKAKALDFANRIRTKERGGKSTLIQLDQGRDEQSFDFWEILGGNSSDPIATTPTPEEQDTESIKTTIYRVGLDVKKNSLRARLAWEGTDWKLPNKEILNTKFVYVVDCVTEIFVWVGKESSSIQRKMATKVALVLQAQKDRVDWTKITRLTEFGENNLFKEKFANYPGMLPISTTRQEIKSHVATSKVEHKIETLASRMTTPFIDNEALFTIPIDEGGRVKVWKIEDYEKIDHPQHLYSQFFSSDSYIVLYTYMQNNKEAHVIYYYLGRDSSINEKGTSAYLTVDLNESLVGACVQTRVVANKECKNFLNLFKTKMVIHKGKYNNYDPKKPSLYQVKGLDKIDIRAVQVEFSSSMLNTLHVSILRTPEKIYIWHGKFSLDAEQNSALSIAENFNSTSAPIEILKEGSESNEFWSAFESTGGRQKYFNDIMIQSSSIPTSFTYKPRFFVCSNASGIVEVTEESPFSQDDLDIGSVCILDVQSHIYLWIGSRATHRTKRASMEVVLNFIETSKLGHSKEHTKVLIATPFEEPIGFKSYFRAWCTSKYPKNKLPLVEKDGIPVEQVLKDYLKEIYTYEELLADPLPAGVDSTKLDTYLNDEDFEKVFKMTRTEWLKIPAWKREGIKKELFLF
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (Q59DQ4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MKMVGCHPNDKKVKYDGIKSKTSSVTILTSVLNDAISALKSAFYKNQAPISEQNRSQIVSRMSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQVNSSNYHFCINQFFIVKY