wanglab/gogpt-training-data huggingface dataset:
Protein: Outer dense fiber protein 2 (84 kDa outer dense fiber protein) (Cenexin) (Outer dense fiber of sperm tails protein 2) (A3KGV1)
Organism: Mus musculus (Mouse)
Function: Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15852003, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:31904090}. Cell projection, cilium {ECO:0000269|PubMed:15852003}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15852003}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:15852003}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:27682589, ECO:0000269|PubMed:31904090, ECO:0000269|PubMed:35587122, ECO:0000269|PubMed:37198331, ECO:0000269|PubMed:38038747}. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles. {ECO:0000269|PubMed:15852003}.
Interaction partners:
- Ninein
- Centrosomal protein of 164 kDa
- Centriolin
- Centrosomal protein of 89 kDa
- Trichoplein keratin filament-binding protein
- Centrosomal protein of 128 kDa
- Centromere protein F
- Centrosomal protein of 170 kDa
- Centrosomal protein of 83 kDa
- Serine/threonine-protein kinase PLK1
Sequence:
MSASSSGGSPRFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSQKVDELERKLEATSAQNVEFLQVIAKREEAIHQAQLRLEEKTRECGSLARQLESAIEDARRQVEQTKEQALSKERAAQSKILDLETQLSRTKTELGQLRRTRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKASYANVFGDAPYTSSYLTSSPIRSRSPPA
Protein: Replicative DNA helicase DnaB (EC 5.6.2.3) (DNA 5'-3' helicase DnaB) (P0ACB0)
Organism: Escherichia coli (strain K12)
Function: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.
Interaction partners:
- DNA primase
- Replicative helicase loader DnaC
- Chromosomal replication initiator protein DnaA
- DNA polymerase III subunit tau
- DNA polymerase III subunit alpha
- Single-stranded DNA-binding protein
- Replication restart protein DnaT
- Replication restart protein PriC
- Beta sliding clamp
- Replication restart protein PriB
Sequence:
MAGNKPFNKQQAEPRERDPQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVADDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLDSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIAEAGFDPQGRTSEDLLDLAESRVFKIAESRANKDEGPKNIADVLDATVARIEQLFQQPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLVENAAMLQDKPVLIFSLEMPSEQIMMRSLASLSRVDQTKIRTGQLDDEDWARISGTMGILLEKRNIYIDDSSGLTPTEVRSRARRIAREHGGIGLIMIDYLQLMRVPALSDNRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYDDE
Protein: Netrin-G2 (Laminet-2) (Q8R4F1)
Organism: Mus musculus (Mouse)
Function: Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11804778}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11804778}; Extracellular side {ECO:0000269|PubMed:11804778}.
Interaction partners:
- Leucine-rich repeat-containing protein 4
- Leucine-rich repeat-containing protein 4C
Sequence:
MLRLLALFLHCLPLVSGDYDICKSWVTTDEGPTWEFYACQPKVMRLKDYVKVKVEPSGITCGDPPERFCSHENPYLCSNECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRYPSPLEANITLSWNKSVELTDDVVVTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSPSSAHRVLCTEEYSRWAGSKKEKHVRFEVRDRFAIFAGPDLRNMDNLYTRMESAKGLKEFFTFTDLRMRLLRPALGGTYVQRENLYKYFYAISNIEVIGRCKCNLHANLCTVREGSLQCECEHNTTGPDCGRCKKNFRTRAWRAGSYLPLPHGSPNACAAAGSAFGSQTKPPTMAPLGDSSFWPQVSSSAEAVAISVAVPSQAKDSTLFELKPRSPQVIPIEEFQDCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCNETGFCECREGAVGPKCDDCLPTHYWRQGCYPNVCDDDQLLCQNGGTCQQNQRCACPPGYTGIRCEQPRCDLADDAGPDCDRAPGIVPRPDTLLGCLLLLGLAARLAC
Protein: CI (O48503)
Organism: Lactococcus phage TP901-1
Interaction partners:
Sequence:
MKTDTSNRLKQIMAERNLKQVDILNLSIPFQKKFGIKLSKSTLSQYVNSVQSPDQNRIYLLAKTLGVSEAWLMGFDVPMVESSKIENDSENIEETITVMKKLEEPRQKVVLDTAKIQLKEQDEQNKVKQIEDYRLSDEYLEEQISKASAYGGGQLNDNDKEFFKRLLKNTLKEKIDKGDL
Protein: Chorismate synthase (CS) (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphate phospholyase) (P56122)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Interaction partners:
- 3-phosphoshikimate 1-carboxyvinyltransferase
- 3-dehydroquinate synthase
- Para-aminobenzoate synthetase
- Anthranilate synthase component 1
- Anthranilate synthase component 2
- Shikimate dehydrogenase
- chorismate mutase
- Prephenate dehydrogenase
- Chorismate dehydratase
- Shikimate kinase
Sequence:
MNTLGRFLRLTTFGESHGDVIGGVLDGMPSGIKIDYALLENEMKRRQGGRNVFITPRKEDDKVEITSGVFEDFSTGTPIGFLIHNQRARSKDYDNIKNLFRPSHADFTYFHKYGIRDFRGGGRSSARESAIRVAAGAFAKMLLREIGIVCESGIIEIGGIKAKNYDFNHALKSEIFALDEEQEEAQKTAIQNAIKNHDSIGGVALIRARSIKTNQKLPIGLGQGLYAKLDAKIAEAMMGLNGVKAVEIGKGVESSLLKGSEYNDLMDQKGFLSNRSGGVLGGMSNGEEIIVRVHFKPTPSIFQPQRTIDINGNECECLLKGRHDPCIAIRGSVVCESLLALVLADMVLLNLTSKIEYLKTIYNEN
Protein: Probable cysteine protease RD19B (EC 3.4.22.-) (RD19-like protein 1) (Thiol protease A1494) (P43295)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable thiol protease.
Subcellular location: Lytic vacuole {ECO:0000269|PubMed:18708476}. Note=Predominantly vacuolar. From the Golgi apparatus, probably transported to the lytic vacuole (LV) in clathrin-coated vesicles (CCVs) via the prevacuolar compartment (PVC). {ECO:0000269|PubMed:18708476}.
Interaction partners:
- Disease resistance protein RRS1
- UPF0235 protein At5g63440
- Vacuolar-processing enzyme beta-isozyme
- Carboxyl-terminal peptidase
- Carboxyl-terminal peptidase
- Carboxyl-terminal peptidase
- Carboxyl-terminal peptidase
- Carboxyl-terminal peptidase
- Probable cysteine protease RD21C
- Probable cysteine protease RD21B
Sequence:
MDYHLRVLFSVSLIFVFVSVSVCGDEDVLIRQVVDETEPKVLSSEDHFTLFKKKFGKVYGSIEEHYYRFSVFKANLLRAMRHQKMDPSARHGVTQFSDLTRSEFRRKHLGVKGGFKLPKDANQAPILPTQNLPEEFDWRDRGAVTPVKNQGSCGSCWSFSTTGALEGAHFLATGKLVSLSEQQLVDCDHECDPEEEGSCDSGCNGGLMNSAFEYTLKTGGLMREKDYPYTGTDGGSCKLDRSKIVASVSNFSVVSINEDQIAANLIKNGPLAVAINAAYMQTYIGGVSCPYICSRRLNHGVLLVGYGSAGFSQARLKEKPYWIIKNSWGESWGENGFYKICKGRNICGVDSLVSTVAATTS
Protein: Integrator complex subunit 14 (von Willebrand factor A domain-containing protein 9) (B4DJL6)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKLYLRTGEGLPEADGKAKEQLSVCILIGNTGIIFIMPTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYIMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLASTGTSEYAAYDQNITPLHTDFSGSSTERI
Protein: Aldehyde dehydrogenase family 3 member B2 (Aldh3B2) (EC 1.2.1.3) (Aldehyde dehydrogenase 8) (Long-chain fatty aldehyde dehydrogenase) (EC 1.2.1.48) (E9Q3E1)
Organism: Mus musculus (Mouse)
Function: Oxidizes medium and long chain aldehydes into non-toxic fatty acids.
Subcellular location: Lipid droplet {ECO:0000269|PubMed:25286108}.
Interaction partners:
- All-trans-retinol dehydrogenase [NAD
- Acetyl-coenzyme A synthetase, cytoplasmic
- Alcohol dehydrogenase class-3
- Aldo-keto reductase family 1 member A1
- All-trans-retinol dehydrogenase [NAD
- Amine oxidase [flavin-containing] A
- Acetyl-coenzyme A synthetase 2-like, mitochondrial
- 4-aminobutyrate aminotransferase, mitochondrial
- Alcohol dehydrogenase 1
- Amine oxidase [flavin-containing] B
Sequence:
MSAAETGSEPSQGAGPSEATLHSLREAFNAGRTRPTEFRTAQLRSLGRFLQENKELLQDALAKDVGKSGFESDMSEIILCENEVDLALKNLQTWMKDEPVSTNLLTKLSSAFIRKEPFGLVLIIAPWNYPVNLMIIPLVGAIAAGNCVVLKPSEISKNTEKVLAELLPQYLDQSCFAVMLGGPEETRQLLEHKFDYIFFTGSPRVGKIVMTAAAKHLTPITLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYILCSQEMQERLVPALQNSITRFYGDNPQTSPNLGRIINQKHFKRLQGLLGCGRVAIGGQSDEGERYIAPTVLVDVQETEPVMQEEIFGPILPLVTVRSLDEAIEFINRREKPLALYAFSNNNQVVNQMLERTSSGGFGGNDGFLYLTLPALPLGGVGNSGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNDLRYPPYGPWNQQLISWAIGSRSCTLL
Protein: Uncharacterized glycosyltransferase YkoT (EC 2.4.-.-) (O34755)
Organism: Bacillus subtilis (strain 168)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized membrane protein YkoS
- Putative mannosyltransferase YkcB
- Uncharacterized transcriptional regulatory protein YkoG
- Sensor histidine kinase YkoH
- Uncharacterized transcriptional regulatory protein YrkP
- Uncharacterized protein YfhO
- Uncharacterized transcriptional regulatory protein YclJ
Sequence:
MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAEDSKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVISIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIKLIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYPLKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLIISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEKKYS
Protein: Immunoglobulin-binding protein EibA (Trimeric autotransporter adhesin EibA) (TAA EibA) (Type 5 secretion system autotransporter EibA) (Q9LA60)
Organism: Escherichia coli
Function: Binds (in a non-immune fashion) to the Fc portion of human IgG but not IgA; binding occurs on the cell surface. Confers the ability to survive exposure to human serum exposure. Binds to the Fc portion of human IgG and to whole mouse antibodies also via Fc, binds more than 1 Fc or IgG.
Subcellular location: Cell surface {ECO:0000269|PubMed:22155776, ECO:0000305|PubMed:10722621, ECO:0000305|PubMed:19303642}. Cell outer membrane {ECO:0000269|PubMed:22155776, ECO:0000305|PubMed:10722621}. Note=The C-terminal translocator domain is localized in the outer membrane and the passenger domain is at the cell surface. {ECO:0000269|PubMed:22155776, ECO:0000305|PubMed:10722621, ECO:0000305|PubMed:19303642}.
Interaction partners:
Sequence:
MSKKFTKAVLSAAMAGVLFGVSFDIMAAEQSYSALNAQNGAGSIYKVYYNPDNKTAHIDWGGLGDVEKERNKPIPLLSKIDGNGNVTITSADGSTTFTVYDKEVHDFMKAAASGKTDDIKTNLLTEQNIRDLYNRVSAIQQMETNVGLDEYGNVAVTPNEIKERVSLQRYLAWESANSTIVANELEAQKGKLDAQKGELEAQKKNLGELTTRTDKIDAAAAATAAKVESRTLVGVSSDGTLTRAEGAKNTISVNDGLVALSGRTDRIDAAVGAIDGRVTRNTQSIEKNSKAIAANTRTLQQHSARLDSQQRQINENHKEMKRAAAQSAALTGLFQPYSVGKFNASAAVGGYSDEQALAVGVGYRFNEQTAAKAGVAFSDGDASWNVGVNFEF
Protein: Quinone oxidoreductase PIG3 (EC 1.6.5.5) (NADPH:quinone reductase PIG3) (Tumor protein p53-inducible protein 3) (Protein PIG3) (p53-induced gene 3 protein) (Q53FA7)
Organism: Homo sapiens (Human)
Function: Catalyzes the NADPH-dependent reduction of quinones. Exhibits a low enzymatic activity with beta-naphthoquinones, with a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro). Involved in the generation of reactive oxygen species (ROS).
Interaction partners:
- Etoposide-induced protein 2.4 homolog
- Cellular tumor antigen p53
- Replication protein A 70 kDa DNA-binding subunit
Sequence:
MLAVHFDKPGGPENLYVKEVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGASNILGLEASGHVAELGPGCQGHWKIGDTAMALLPGGGQAQYVTVPEGLLMPIPEGLTLTQAAAIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQLTRMAGAIPLVTAGSQKKLQMAEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIGGSYWEKNVNCLALDGRWVLYGLMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTEGPQRLLPVLDRIYPVTEIQEAHKYMEANKNIGKIVLELPQ
Protein: Protein kinase, putative (EC 2.7.1.-) (Q385I2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Intraflagellar transport
- BRCT domain-containing protein
- BTB domain-containing protein
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
Sequence:
MCGKDSSHDYSTLVTALSRTMVFKQDSHPRYEGPVALKVAAKSGSDDRGMHPSLHEAGVYKLICPHPSIPDYVDCVEDWFDTERFLAEEERRGEQRLPVLVTQFIKAVALDRFLCSVRVIRWSVVIHIANQLVEVLKHINSKGVVYRDLKLPNVIIGAGGNVWLVDYASSMIVGGEEPSSGVTSHMRPPESFEFPDHQSGEQISQAQLSFMADFWVFGAFLLEILSGRPYLGSFDVRSSHLTQSQLEEKVLEGVSVIKDRYKGAYYNRRFNKSFPCNAKTLWDALTGLLIKLLRRNPKERLGHDGGWYAVKQQPFFKYTLCDLTVPFPLDYEDEIEELMAGF
Protein: (thale cress) hypothetical protein (A0A384L1A6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDTGGFVDEESDGSQASAQSSSSQAVSHSDEAMSRPSGVKAAKAAKAKRTLSVIKSMWEIKQKEFELNEKLSKKTLLETLLRKTAPLSDLEMALKNKLITDILSNA
Protein: Anoctamin-4 (Transmembrane protein 16D) (Q32M45)
Organism: Homo sapiens (Human)
Function: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000269|PubMed:22946059}. Note=Shows an intracellular localization. {ECO:0000250|UniProtKB:Q8C5H1}.
Interaction partners:
- Vesicular glutamate transporter 3
Sequence:
MEASSSGITNGKTKVFHPEGGVDLQGYQLDMQILPDGPKSDVDFSEILNAIQEMAKDVNILFDELEAVSSPCKDDDSLLHPGNLTSTSDDASRLEAGGETVPERNKSNGLYFRDGKCRIDYILVYRKSNPQTEKREVFERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKETFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHSQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKKNGKAHHNEWP
Protein: Leucine-zipper-like transcriptional regulator 1 (LZTR-1) (Q9CQ33)
Organism: Mus musculus (Mouse)
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes.
Subcellular location: Endomembrane system {ECO:0000250|UniProtKB:Q8N653}. Recycling endosome {ECO:0000250|UniProtKB:Q8N653}. Golgi apparatus {ECO:0000250|UniProtKB:Q8N653}.
Interaction partners:
- Cullin-3
- Synaptosomal-associated protein 29
- Kelch-like protein 22
- Kelch repeat and BTB domain-containing protein 8
- Kelch-like protein 3
- Kelch-like protein 7
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
- Kelch-like protein 8
- Gigaxonin
- Kelch-like protein 40
Sequence:
MAGSGGPIGSGALTGGVRSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEMPERASSSEDASTLTSEERSSFKKSRDVFGLDFGTTSAKQPVHLASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWEGRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKIVQAQEWLAQKLEEDGALAPKEAPGPAVGRARPPLLRVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPSDQPVDIGTSLIQDMKAYLEGAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRLLSQQLLLDIIDSLASHISDKQCAELGADI
Protein: LD22804p (Zinc transporter 63C, isoform A) (Zinc transporter 63C, isoform B) (Zinc transporter 63C, isoform C) (Zinc transporter 63C, isoform D) (Zinc transporter 63C, isoform E) (Zinc transporter 63C, isoform G) (Q7K3K5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAKYSGKKCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKWSKNTFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLCLLYEHGGHHGHSHGGGLTRNHSRLTELANMDEGEDEQNDFAYEKQKEKAPVKKSSHGHSHDPGQMNMRGAFLHVLSDALGSIIVVISAVVVWKTEWKYRYYMDPALSIVLVVLILHSVWPLLRESALILLQTVPTHIQVDAIQKRLLEKVDGVLAVHEFHVWQLAGDRIIASAHIRCRNLSEYMKIAEKVKEFFHNEGIHSTTIQPEFSEIEGCNMSDGTSSINISGSDCCALDCPTTEEGCVKATCCQNNNKLNQLPSPTNSPYLCRQRNAARQAGDVEAGSLLEATSSGNQGATGGASTGAPVAAIGATSTPKSDLV
Protein: Leucine rich repeats and calponin homology domain containing 3 (H7C1G3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
AVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSDDRPNALLSSPATETGHASPLPPSAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPKQQQHQLSAV
Protein: Insulin-like growth factor 2 (Erythrotropin) (Insulin-like growth factor II) (IGF-II) [Cleaved into: Preptin] (P07456)
Organism: Bos taurus (Bovine)
Function: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P01344, ECO:0000250|UniProtKB:P09535}.
Interaction partners:
- Cation-independent mannose-6-phosphate receptor
- Insulin-like growth factor 1 receptor
- Insulin-like growth factor-binding protein 1
- Insulin-like growth factor-binding protein 2
- Insulin-like growth factor-binding protein 3
- Insulin-like growth factor-binding protein 6
- Insulin-like growth factor 1
- Glypican-3
- Tyrosine-protein kinase receptor
- Insulin-like growth factor-binding protein 5
Sequence:
MGITAGKSVLVLLAFLAFASCCYAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPSSRINRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSASTTVLPDDVTAYPVGKFFQYDIWKQSTQRLRRGLPAFLRARRGRTLAKELEALREAKSHRPLIALPTQDPATHGGASSKASSD
Protein: DNA topoisomerase (EC 5.6.2.1) (Q383X7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- RecQ mediated genome instability protein 1 OB-fold domain-containing protein
- DNA topoisomerase
- DNA 3'-5' helicase
- DNA 3'-5' helicase
- Crossover junction endonuclease MUS81
- DNA repair protein, putative
- Replication protein A subunit
- Uncharacterized protein
- DNA repair protein RAD50
- DNA repair protein RAD51 homolog
Sequence:
MTIWLNVAEKPSVAREIATILSGGNQRTIRSHSIYNPVFEFNFEGKTMICTSVSGHLMESDFPPQAAGWASFPIIDLFTLGTVKRVRSDLSEIQKNLRELGRRATTLALWMDCDREGENICFEVIDVVQKEHSSISICRAHFSALTKRDILGAMRNLKAPNRALSEAVEARQELDLRLGAVFTRFQTLKFCSQFKNFPKVLSFGPCQFPTLGFLVQRGWEQKGFVPEDYFTLTLQHGDTSFNSVRGPIYDKIAAAVVLQQMFDEARTRPEAEVVEVMKRPNRRRPPFPLSTVMLQKLCTAHLRISSDQCMTWAESLYQEGYISYPRTETDSFSFTDNELLDIVGSQRRNPEVSGFVEAMLADPNRKFRRPLNGGHDDKAHPPIYPTKPMPAANDGRAKLYNLIVRHFLACTSPDAVASTTSVAVVYGGEKFTTSGTTIDEKGWMEVYIYERWKSTTLPTYKQGERFRPTHADLEQHRTSPPPNLTEADLITLMDKHGIGTDATISHHIKTVVEREYVKREGSSLVPTHVGNALASAYEVNGLVSLLQPQMRAQMELAMADIAAGKATRRDVVDAAVRLYREIFQKMLSLTDAMNRVLHLHLDPVYQTAVEEVGTSRAHISASGLVECGTCGNPMNLMEHVQKERNPWFVRCDTCQKEYRVPNGRHNRIERSGHRCVICKFGVLEITNIDKGTSHTVCPYCFTSPPPGAEMESLAEFRCFHCGADCPLAKGHETVTITNCMSCKKNGLRIRSNNSGFFLACRGFPVCNFTIKLPPAERVSLAYDARCPSCSAIMLKFDFGGSPAVPGVQEGEKVCVFCDARMKEHIRTKGNNVLRGSRSAPQERQLAQQQQPRPAYTLPSIDVNSGLFQIPPGLADGAATPLCHCGLPAVHLVSGQAASRGRRFVKCDGSKCQFFQWLD
Protein: MYB2 (Myb family transcription factor 2/fiber factor 1) (Transcription factor WER-like protein) (Q66Q66)
Organism: Gossypium arboreum (Tree cotton) (Gossypium nanking)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAPKKDGVSKRVFNKGSWTAEEDRRLAKYIEIHGAKRWKTIAIKSGLNRCGKSCRLRWLNYLRPNIKRGNISDEEEDLIIRLHKLLGNRWSLIAGRLPGRTDNEIKNYWNSHLSKKIINHDVRTEQTSSSEQIVPHKAWETVQMEEEEVVKGSDEIENSEFSIDVDEFFDFTTEGCFSLDWVNKFLELDDQQDPLAMV
Protein: Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (Q9Z2G8)
Organism: Rattus norvegicus (Rat)
Function: Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P28656}. Melanosome {ECO:0000250|UniProtKB:P55209}. Cytoplasm {ECO:0000250|UniProtKB:P28656}.
Interaction partners:
- Nucleolin
Sequence:
MADIDNKEQSELDQDLEDVEEVEEEETGEETKIKARQLTVQMMQNPQILAALQERLDGLVDTPTGYIESLPKVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKPDEEDEVSEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNDLLSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFILEFHFEPNEYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSKTSFFNFFAPPEVPENGDLDDDXEAILAADFEIGHFLRERIIPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ