wanglab/gogpt-training-data huggingface dataset:
Protein: MARVEL domain-containing protein 2 (Tricellulin) (Q3UZP0)
Organism: Mus musculus (Mouse)
Function: Plays a role in the formation of tricellular tight junctions and of epithelial barriers. Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16365161, ECO:0000269|PubMed:17186462, ECO:0000269|PubMed:26677943}; Multi-pass membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000269|PubMed:16365161, ECO:0000269|PubMed:17186462, ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:24889144, ECO:0000269|PubMed:25217574, ECO:0000269|PubMed:26677943}. Note=Found at tricellular contacts. {ECO:0000269|PubMed:16365161, ECO:0000269|PubMed:17186462, ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:24889144, ECO:0000269|PubMed:25217574, ECO:0000269|PubMed:26677943}.
Interaction partners:
- Tight junction protein 1
- Tight junction protein 2
- Tight junction protein ZO-3
- Occludin
- Lipolysis-stimulated lipoprotein receptor
- Junctional adhesion molecule A
- MARVEL
- Tubulin alpha-1A chain
- Tubulin alpha-1C chain
- Tubulin alpha-8 chain
Sequence:
MSSSDARSRIRDRGYSEVPRDTSCPDGTIRTFQSLHSSELAVSADPLPPPPLPLQPPFGPSFYSSDTEEPAVAPDLKPVRRFVPDSWKNFFRGKKKDPEWDNPVSDIRYISDGVECSPPASPARANHHPYKDPSRGSQGTFNSQHEADAMFAHDPYASLDRRTQTARTYSEKVEEYNLRYAYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDNEWYNLFGYTQPYGMGGLGSLGNTYGGYYYSGPKTPFVLVVAGLAWITTIIILVLGMSMYYRTILLDSNWWPLTEFGVNVALFILYMAAAIVYVNDTNRGGLCYYPLFNTPMNAMFCRVEGGQIAAMIFLFVTMIVYLVSALVCLKLWRHEAARRHREFLEQQEINDPSLSSKRKMCEAAISDRQRDQEVNVKDLRTTTKMTPELLSGHIPPGHIPKPIVMPDYVAKYPVIQTDDDRERYKAVFQDQFSEYKELSAEVQAILRKFDELDTVMSRLPHHSENRQEHERISRIHEEFRKKKNDPSFLEKKERCDYLKNKLSHIKQRIQEYDKVMNWDTQGYP
Protein: Serine/threonine-protein kinase SAPK10 (EC 2.7.11.1) (Osmotic stress/abscisic acid-activated protein kinase 10) (stress-activated protein kinase 10) (OsSAPK10) (Q75H77)
Organism: Oryza sativa subsp. japonica (Rice)
Function: May play a role in signal transduction of hyperosmotic response. Together with PYL10, PP2C53 and SAPK8, may form an abscisic acid (ABA) signaling module involved in stress response. Together with PYL3 and PP2C50, may form an ABA signaling module involved in stress response.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:26491145}. Nucleus {ECO:0000269|PubMed:26491145}.
Interaction partners:
- Probable protein phosphatase 2C 6
- Protein phosphatase 2C 50
- bZIP transcription factor TRAB1
- bZIP transcription factor ABI5 homolog
- protein-serine/threonine phosphatase
- Probable protein phosphatase 2C 68
- bZIP transcription factor 46
- Probable protein phosphatase 2C 30
- bZIP transcription factor 23
- Probable protein phosphatase 2C 8
Sequence:
MDRAALTVGPGMDMPIMHDGDRYELVRDIGSGNFGVARLMRSRADGQLVAVKYIERGDKIDENVQREIINHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKIADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECRDLIARIFVANPATRISIPEIRNHPWFLKNLPADLMDDSKMSSQYEEPEQPMQSMDEIMQILAEATIPAAGSGGINQFLNDGLDLDDDMEDLDSDPDLDVESSGEIVYAM
Protein: Nascent polypeptide-associated complex subunit beta (Q9CAT7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Nascent polypeptide-associated complex subunit alpha-like protein 4
- Nascent polypeptide-associated complex subunit alpha-like protein 5
- Nascent polypeptide-associated complex subunit alpha-like protein 1
- Nascent polypeptide-associated complex subunit alpha-like protein 3
- Nascent polypeptide-associated complex subunit alpha-like protein 2
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein eL31x
- Large ribosomal subunit protein eL31z
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein uL23z
Sequence:
MNREKLMKMANTVRTGGKGTVRRKKKAVHKTTTTDDKRLQSTLKRVGVNSIPAIEEVNIFKDDVVIQFINPKVQASIAANTWVVSGTPQTKKLQDILPQIISQLGPDNLDNLKKLAEQFQKQAPGAGDVPATIQEEDDDDDVPDLVVGETFETPATEEAPKAAAS
Protein: Ethylene-responsive transcription factor ERF019 (O80542)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- At4g34790
- AT-hook motif nuclear-localized protein 11
- At3g10000
- NAC
Sequence:
MDYRESTGESQSKYKGIRRRKWGKWVSEIRVPGTRDRLWLGSFSTAEGAAVAHDVAFFCLHQPDSLESLNFPHLLNPSLVSRTSPRSIQQAASNAGMAIDAGIVHSTSVNSGCGDTTTYYENGADQVEPLNISVYDYLGGHDHV
Protein: SH2 domain-containing protein 5 (Q8JZW5)
Organism: Mus musculus (Mouse)
Function: May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.
Subcellular location: Postsynaptic density {ECO:0000269|PubMed:25331951}.
Interaction partners:
- Breakpoint cluster region protein
Sequence:
MQRAGAGARRASDCGPAPYRPRCIAKLAQYVGSFPVDDLDTQESVGLVQQQLWALQDCSRRRAVILKFSLQGLKIYSGEGEVLLMAHALKRILYATWYPAACQFAFIARNPRSPSSKLFCHLFVGSQPGEVHILYLLLCRSFQLAYLLQHPEERAQSEPCLAPVGDLSLKPLCSPGVPPALVREPFSRDQLSQNVHALVSFRRLPAEGLLGSNGKELPESEGRGGTRHIRLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRGPGGPSCLVENEGSLTENIWAFAGLSRSCALSLLRRDVHGAFLLWPEPGTSDQWSLSVRTQCGVVPHQVFRNHLGRFCLEHLPAEFPSLEALVESHAGVERSLFCPLSMGRLNPTYEEQDCGTEGRFPRTLRPLSHAKSEAELQGLG
Protein: Protein pelota homolog (EC 3.1.-.-) (Q9YAZ5)
Organism: Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Function: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01853}.
Interaction partners:
- Elongation factor 1-alpha
- ABCE1 homolog
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein eL15
- Small ribosomal subunit protein eS17
- Small ribosomal subunit protein eS4
- Large ribosomal subunit protein P1
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS3
Sequence:
MRVEVLDNKRRIVRLRPESEEDLWLLRITLRPGDVVRIRTSRDVPVGSGRKERVVMTLRIRLDSIEFQPFTGKLRISGIVVEGPDEFGVKGRRHSTAVSIGTWLVVERDKGWSEQELERLASGRARGTAVIAAVDYDEFALAVLAGHGMKILEDTSARLPGKDDPSREQEVEKYVDRAAKRIVEEAARHRSPIAVIAGPGQLKTSVAEKVQRAMPSLKVATVDTSMGGVAGVREALRRESVTRILRELSIVEAEGVLEEFLRRIAKSRDTVAYTPGEVLAVARMGAVDTVLLVDTLLHSPDDAVREAVDEALRLVESMGGRVIIIPGDSPAGERLVSFGGVIALLRYPVPQEARRL
Protein: Pentatricopeptide repeat-containing protein At4g02820, mitochondrial (Q9SY07)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Pentatricopeptide repeat-containing protein At3g02490
- DEAD-box ATP-dependent RNA helicase 32
- At4g13070
- Small ribosomal subunit protein mS77
- UBP1-associated proteins 1B
- Alba DNA/RNA-binding protein
- S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
- Polynucleotidyl transferase, ribonuclease H-like superfamily protein
- Mitochondrial import inner membrane translocase subunit TIM14-2
- rRNA
Sequence:
MNKNMLVRSARPTLASIHRLFSAAAAATVDTATAPVVKPRSGGGKGGESANKKETVVGGRDTLGGRLLSLVYTKRSAVVTIRKWKEEGHSVRKYELNRIVRELRKIKRYKHALEICEWMVVQEDIKLQAGDYAVHLDLISKIRGLNSAEKFFEDMPDQMRGHAACTSLLHSYVQNKLSDKAEALFEKMGECGFLKSCLPYNHMLSMYISRGQFEKVPVLIKELKIRTSPDIVTYNLWLTAFASGNDVEGAEKVYLKAKEEKLNPDWVTYSVLTNLYAKTDNVEKARLALKEMEKLVSKKNRVAYASLISLHANLGDKDGVNLTWKKVKSSFKKMNDAEYLSMISAVVKLGEFEQAKGLYDEWESVSGTGDARIPNLILAEYMNRDEVLLGEKFYERIVEKGINPSYSTWEILTWAYLKRKDMEKVLDCFGKAIDSVKKWTVNVRLVKGACKELEEQGNVKGAEKLMTLLQKAGYVNTQLYNSLLRTYAKAGEMALIVEERMAKDNVELDEETKELIRLTSQMRVTEISSTIS
Protein: SWI5-dependent HO expression protein 4 (P51534)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for mother cell-specific ho expression. Might be required for the transport of factors (such as ASH1) that promote HO repression from the mother cell into its bud.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Myosin-1
- Myosin-3
- Myosin-4
- Myosin-2
- Myosin-5
- ATP-dependent molecular chaperone HSP82
- ATP-dependent molecular chaperone HSC82
- Cytochrome b-c1 complex subunit 7, mitochondrial
Sequence:
MPLCEKGNDPIDSSTIDSLCAAFDKTLKSTPDVQKYNDAINTIFQLRQKSESGKMPADLTNSEALKDRQKIEEILTRSYQDHSESRVHLSKLIQNDIPFALNLFEILSRSSIHVFVGCFSNKDATIALLNELQIRIHYGEDTHVTYLLSIILQLLNKFKYNFKEVRFLVKELILRISEDEVKSMMLIIFAELQSSFQKDFDKAVVDFMSSLIVEAEIDVGNDPLSIIVKTLSELYPSLTTLCSEIFLTKGLSKLFKKRVFEEQDLQFTKELLRLLSSACIDETMRTYITENYLQLLERSLNVEDVQIYSALVLVKTWSFTKLTCINLKQLSEIFINAISRRIMPKIENVNESAVKLEEVPKVEMSVEALAYLSLKASVKIMIRSNESFTEILLTMIKSQKMTHCLYGLLVIMANLSTLPEESNGSSQSINDLKNYADLKGPGADKVGAEKESKEDILLFNEKYILRTELISFLKREMHNLSPNCKQQVVRVIYNITRSKNFIPQCISQGGTTIILEYLANKQDIGEPIRILGCRALTRMLIFTNPGLIFKKYSALNAIPFLFELLPRSTPVDDNPLHNDEQIKLTDNYEALLALTNLASSETSDGEEVCKHIVSTKVYWSTIENLMLDENVPLQRSTLELISNMMSHPLTIAAKFFNLENPQSLRNFNILVKLLQLSDVESQRAVAAIFANIATTIPLIAKELLTKKELIENAIQVFADQIDDIELRQRLLMLFFGLFEVIPDNGTNEVYPLLQENQKLKDALNMSLKRGDSGPEFSAAIPVILAKIKV
Protein: Casparian strip membrane protein 4 (AtCASP4) (Q9FFZ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates membrane-cell wall junctions and localized cell wall deposition. Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21593871}; Multi-pass membrane protein {ECO:0000269|PubMed:21593871}. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain.
Interaction partners:
- CASP-like protein 4C1
- Mechanosensitive ion channel protein 4
- LRR receptor-like serine/threonine-protein kinase GSO1
- Mechanosensitive ion channel protein 6
- Elongation factor 1-alpha 2
- Elongation factor 1-alpha 3
- Precursor of CEP8
Sequence:
MKSDSIAVDVPAESSSVIKGKAPLLGLARDHTGSGGYKRGLSIFDFLLRLAAIVAALAAAATMGTSDETLPFFTQFLQFEASYDDLPTFQFFVVAIAIVAGYLVLSLPFSVVTIVRPLAVAPRLLLLVLDTAALALDTAAASAAAAIVYLAHNGNTNTNWLPICQQFGDFCQKTSGAVVSAFASVTFLAILVVISGVSLKRP
Protein: CAP, isoform X (A0A0B4K7L3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
Interaction partners:
- Calpain-D
- SD23764p
- Vacuolar protein sorting-associated protein VTA1 homolog
- GTP cyclohydrolase 1
- Vinculin
- E3 ubiquitin-protein ligase CBL
Sequence:
MPNNRNRNRNRNRNKRNRNQNQNQNPSQNQNENHQQQAEGAEDREEQQDFQTQIAVAQSSSFVDDNGNSGSVSNGPTENSEEVTNTLEKTEKKEEIFEQPATVIQKEADSDAEMGAKNSKHRKEKSDKQASNGKSEEQVRPPPTIIRRPPGSPRQAKVIVHRIVREEDTANGKAQSPEPPKAVESKEQHMEVEDSKKEKPEAQQEIETKEERENEPSPKELPESSHLSEDAQQKHVEVEENQQVYDEVDYSKDETTDNNPQQEQHDSKEPEQYVLQLEKAMEFVENAHQQHVAAVQSYQKQRDTEQNAQQQEQNEAQHLQESTKAHQQNIAVPQILVDPKKREEGLAQQLHHDVKEEPILNNAQQQNDDTAPKSPKEVTIKVQFQTEDPYSQQPPPQKPTSKVIIHQIHVETTDEEQNAKPTFEEVSSTTGSLAGTLSPPPRYLVESPKNVSSGQFSNFSRNVQIQEMELNSDFSSGEFNSLQSPLVCEVDSESEGSVVLGPERSPSDQQVPSSSRVEQHEQVRQKRAQYRNALESHFMPQLLNPRYLDSILEENEWRNSTASSGGSDQTGIRTPKLNETFPRSQLDFSRRHKRREEAPSPLKLETKLLEESTDLESCTRLQSALSPQSEDAELVYLSSSASSSVSDLMELELEQAAALAERALVDLDTDASRLIARPDDEMSSTSTTTADRSETEAETETETEREGEQSRESTPVNANPTLASSQSSLLSAATPTPTPTPTPADREQLAKDTNVSGGSTVSFGAASPLAATREEFVRNMDKVRELIEMTRREQEQGELPRSPSPPPVPPPPASVPPYSPESSSFHLASLQLKRQESNDSHCSDSTTHSQCTAINLASPPPPPTAQPPTPPLRQKPAPPPVPQPVSPPAPPTPQSEPELSVADSVANANADVDADADTDTEAIKKLRLLCTEQLASMPYGEQVLEELASVAQNISDQSQNKMPYPMPQLPHIKELQLNANESKSSSAWLGLPTQSDPKLLVCLSPGQRDLVNNQTQPDDLLDAHQKFVERRGYHELSKAQVLEQDHQQQQSEMLKTAAMMRELRKSLSPPAPPVPPPPVPVKSAETAAKATAHENAKRDDASEQKQKIAACESSSLENKPRRAADLGAQQSAEQRQSSSTTTSSHKATTETMSSDTAKFPTLDSMESELARMFPQHKGDIFEEQRKRFSNIEFPSHQPVSQTKRYSNIETSSYESKKRMENGQVVYDVSTSSHEKKEQGDPPKDQPVPPVPPPPIMSATKLNGNTFIDGDVAPKNSQPSRESGSGSGNGTYEEFRQRAKAAADAFGEQREQQNGLDQDRVFKDFDRLSQQMHAELQSTREKREKSASMYDLSGFTRPASGHPRLDELQQRRHAHMQELEREIERSAKSRQERMSSVPRQMEATPPRTHEIPIELEPRSRRAESLCNLNEPPPRPHTTVGHYNHPVVQDDWSRYANDLGYSENIARPFAREVEICYQRQNQRTPHCIRAPRLSASTNDLSSSSQYSYDTFNAYGGRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSRRGVSPAPPPVATPQQQQVPPPAYDRQQRRSSLPRELHEQQLKYILSKEEELKFEVERLQQERRRLMEEMQRAPVLPAPQRRESYRPAAKLPTLSEDEVFRQQMAEEWMNKVAEREERRQHKIIRISKIEDEHDHSAVDKATISDEFLDRVKERRHKLSMPADSDWESGAESQPQPAAQSQPESDVEAPPVRILEGQAEANLRQLPRHLREFAKFSTSEQLPDGAQMERHEEQERREEATDNAHSSATKKTSIVKTYKVSRLPPSVQDRAIASEEANSAATGMGVRLRPRPPKQTRFLLNAQQLQQQRQRRSWSESDLLKEIDSELQLAKGFLYANVYKVKHEYMSEPETGSDRPRKMAQLGRRQYDGIGPVTNDGMPIILRSEVKEPHQHEWYKRLYQTIHKQKNGARPSYKSNGYVSEPEPNYDSDYSTVRYRTQNPHRVQSVSSAVNVRNLNQDEKLYGTMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKENLEQSKLSPLYTEGNLSRALAKESGYTSDSNLVFRKKEVPVSSPLSPVEQKQAYKSLQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVKGLSSYDFPYSTDTVDGSDVNIHFKTPIRHEQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSKRPSEGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKIANRKGIFPCSYVEVLTDIGAEDIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKTDALHVDTSSEPLAYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVERA
Protein: BPI fold-containing family B member 2 (Bactericidal/permeability-increasing protein-like 1) (BPI-like 1) (Long palate, lung and nasal epithelium carcinoma-associated protein 2) (RYSR) (Q8N4F0)
Organism: Homo sapiens (Human)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- BPI fold-containing family B member 1
- BPI fold-containing family A member 1
- BPI fold-containing family A member 2
Sequence:
MAWASRLGLLLALLLPVVGASTPGTVVRLNKAALSYVSEIGKAPLQRALQVTVPHFLDWSGEALQPTRIRILNVHVPRLHLKFIAGFGVRLLAAANFTFKVFRAPEPLELTLPVELLADTRVTQSSIRTPVVSISACSLFSGHANEFDGSNSTSHALLVLVQKHIKAVLSNKLCLSISNLVQGVNVHLGTLIGLNPVGPESQIRYSMVSVPTVTSDYISLEVNAVLFLLGKPIILPTDATPFVLPRHVGTEGSMATVGLSQQLFDSALLLLQKAGALNLDITGQLRSDDNLLNTSALGRLIPEVARQFPEPMPVVLKVRLGATPVAMLHTNNATLRLQPFVEVLATASNSAFQSLFSLDVVVNLRLQLSVSKVKLQGTTSVLGDVQLTVASSNVGFIDTDQVRTLMGTVFEKPLLDHLNALLAMGIALPGVVNLHYVAPEIFVYEGYVVISSGLFYQS
Protein: Protein FAM50A (Protein HXC-26) (Protein XAP-5) (Q14320)
Organism: Homo sapiens (Human)
Function: Probably involved in the regulation of pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:32703943}.
Interaction partners:
- THO complex subunit 4
- Regulator of nonsense transcripts 3B
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-processing factor 17
- Spliceosome RNA helicase DDX39B
- Serine/arginine repetitive matrix protein 1
- Peptidyl-prolyl cis-trans isomerase-like 1
- Pre-mRNA-splicing factor SYF2
Sequence:
MAQYKGAASEAGRAMHLMKKREKQREQMEQMKQRIAEENIMKSNIDKKFSAHYDAVEAELKSSTVGLVTLNDMKAKQEALVKEREKQLAKKEQSKELQMKLEKLREKERKKEAKRKISSLSFTLEEEEEGGEEEEEAAMYEEEMEREEITTKKRKLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAKQEKIKSEEIEITFSYWDGSGHRRTVKMRKGNTMQQFLQKALEILRKDFSELRSAGVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDVRLLSDATVEKDESHAGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR
Protein: 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase (CHMS dehydrogenase) (EC 1.1.1.312) (2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase) (Q9KWL3)
Organism: Sphingobium sp. (strain NBRC 103272 / SYK-6)
Function: Involved in the degradation of protocatechuate (PCA) via the PCA 4,5-cleavage pathway. Catalyzes the oxidation of the hemiacetal form of 4-carboxy-2-hydroxymuconate-6-semialdehyde (CHMS) to produce 2-pyrone-4,6-dicarboxylate (PDC). LigC has 10-times-higher affinity to NADP than to NAD.
Interaction partners:
- Protocatechuate 4,5-dioxygenase beta chain
- Protocatechuate 4,5-dioxygenase alpha chain
- 2-pyrone-4,6-dicarboxylate hydrolase
- Protocatechuate 4,5-dioxygenase alpha chain
- Protocatechuate 4,5-dioxygenase beta chain
- Protocatechuate 4,5-dioxygenase beta chain
- Protocatechuate 4,5-dioxygenase alpha chain
- 3-O-methylgallate 3,4-dioxygenase
- Putative hydrolase
- 2-keto-4-carboxy-3-hexenedioate hydratase
Sequence:
MRIALAGAGAFGEKHLDGLKNIDGVEIVSIISRKAEQAAEVAAKYGAKHSGTDLSEALARDDVDAVILCTPTQMHAEQAIACMNAGKHVQVEIPLADSWADAEAVMKKSQETGLVCMVGHTRRFNPSHQYIHNKIVAGELAIQQMDVQTYFFRRKNMNAKGEPRSWTDHLLWHHAAHTVDLFAYQAGKIVQANAVQGPIHPELGIAMDMSIQLKSETGAICTLSLSFNNDGPLGTFFRYICDNGTWIARYDDLVTGKEEPVDVSKVDVSMNGIELQDREFIAAIREGREPNSSVARVLDCYRVLGELEVQLEKQG
Protein: Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Q9JID2)
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNAQ, required for heart development (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P29992}; Lipid-anchor {ECO:0000250|UniProtKB:P29992}. Cytoplasm {ECO:0000250|UniProtKB:P29992}.
Interaction partners:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
- Guanine nucleotide-binding protein G
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Extracellular calcium-sensing receptor
- Guanine nucleotide-binding protein G
- Cholecystokinin receptor type A
- Growth hormone secretagogue receptor type 1
- C-C chemokine receptor type 5
Sequence:
MTLESMIACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAVVRAMDTLKIRYKYEQNKANALLIREVDVEKVTTFEHQYVNAIKTLWSDPGVQECYDRRREFQLSDSAKYYLTDVDRIATVGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQHSSVILFLNKKDLLEDKILHSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
Protein: Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] (Q64737)
Organism: Mus musculus (Mouse)
Function: Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway.
Interaction partners:
- Bifunctional purine biosynthesis protein ATIC
- Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
- Amidophosphoribosyltransferase
- Serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- C-1-tetrahydrofolate synthase, cytoplasmic
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
- Adenylosuccinate lyase
- Monofunctional C1-tetrahydrofolate synthase, mitochondrial
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
Sequence:
MAARVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTACAGKISNAAVSVNDHSALAQFCKDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIPTAQWRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQAEACRAVQEIMQEKSFGAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPAPQVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQVILPLLKSDLYEVMQSTLDGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEITGFPEAQALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEGAIYRKDIGFRAVAFLQRPRGLTYKDSGVDIAAGNMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSTTEAVIAGIAAACQQAGCALLGGETAEMPNMYPPGEYDLAGFAVGAMERHQKLPQLERITEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTRIYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPQKFGVDLDASTWRVPKVFSWLQQEGELSEEEMARTFNCGIGAALVVSKDQAEQVLHDVRRRQEEAWVIGSVVACPEDSPRVRVKNLIETIQTNGSLVANGFLKSNFPVQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLVISNKAAVAGLDRAERAGIPTRVINHKLYKNRVEFDNAVDHVLEEFSVDIVCLAGFMRILSGPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEAVPVRRGDTVATLSERVKVAEHKIFPAALQLVASGAVQLREDGKIHWAKEQ
Protein: Caldesmon 1 (E9Q0M9)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEAHVQNSVPDEESKPASSNTQVEGDEEAALLERLARREERRQKRLQEALERQKEFDPTITDGSLSGPSRRMQNDSAENETAEGEEKRESRSGRYEVEETEVVIKSYQKNSYQDAEDKKKEEKEEEEQEKLKGGSLGENQIKDEKIKKDKEPKEEVKSFLDRKKGFTEVKAQNGEFMTHKLKQTENAFSRSGGRASGDKEAEGAPQVEAGKRLEELRRRRGETENEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKAREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSEDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSGVRSTHQAAVVSKIDSRLEQYTNAIEGTKASKPMKPAASDLPVPAEGVRNIKSMWEKGSVFSAPSASGTPNKETAGLKVGVSSRINEWLTKSPDGNKSPAPKPSDLRPGDVSGKRNLWEKQSVDKVTSPTKV
Protein: Zinc finger protein 785 (A8K8V0)
Organism: Homo sapiens (Human)
Function: May be involved in transcriptional regulation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MGPPLAPRPAHVPGEAGPRRTRESRPGAVSFADVAVYFSPEEWECLRPAQRALYRDVMRETFGHLGALGFSVPKPAFISWVEGEVEAWSPEAQDPDGESSAAFSRGQGQEAGSRDGNEEKERLKKCPKQKEVAHEVAVKEWWPSVACPEFCNPRQSPMNPWLKDTLTRRLPHSCPDCGRNFSYPSLLASHQRVHSGERPFSCGQCQARFSQRRYLLQHQFIHTGEKPYPCPDCGRRFRQRGSLAIHRRAHTGEKPYACSDCKSRFTYPYLLAIHQRKHTGEKPYSCPDCSLRFAYTSLLAIHRRIHTGEKPYPCPDCGRRFTYSSLLLSHRRIHSDSRPFPCVECGKGFKRKTALEAHRWIHRSCSERRAWQQAVVGRSEPIPVLGGKDPPVHFRHFPDIFQECG
Protein: Zinc transporter (D3W9Z8)
Organism: Aspergillus fumigatus (Neosartorya fumigata)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAKALLLLSLLGGLGLAHAQYVTYTGCHNHGSTEYCFGPDGKETPFPTPTESASRTVPVTVAAAAAATTTSSADASAVTGCHSHGSDVFCIDGDGNEVQVILPSTPTGELPAQYTGCHSHGSETFCMDPEGNDVQIVGEEGSTEGSSSSGSSGESQSGSKEGMNCHFHAGVEHCIGAGESESGSSQKSCGLRTRDYDVPLRIGTLFVVLVTSSIGVFLPMLLVKLPSAKINGVVSTVIKQFGTGVILSTAFVHLYTHANLMFTNECLGELEYEATTSAVVMAGIFLSFLFEYIGHRIILARATRCASPCPEQTGDMSPSSTSKELPASQPPPPPPQQQQQQPPTLAALGHHHGPPLDPTNPNTKLSVLVMEAGVVFHSILIGLTLVVAGDSFYKTLLVVIVFHQFFEGLALGARIAMLPGPLLGSKALMAGTFAVITPIGMAIGLGVLHSFNGNDQSTLVALGTLDALSAGILVWVGLVDMWARDWVMDGGEMMNARLSIVAVGGFSLIAGMVLMGVLGKWA
Protein: KCNQ potassium channel, isoform F (A1Z856)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL43
- Large ribosomal subunit protein uL14
- 40S ribosomal protein S24
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein eL38
- FI01658p
- GH19970p
- Small ribosomal subunit protein eS17
- Small ribosomal subunit protein eS6
Sequence:
MDPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANEEDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGKQGSKAKDVYASKISLASRVVKVERQVADIEEKLDILIKAYMEDRDRFLALPLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSELRSLTATQTPTTTTDAIATQTPMPPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELENRTKKRVTLSLHRSTSEPYSKQEQRITIPDEGADSLDSSAKPTPPDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSDIGVEVDVDADADGDCDESTEDTALLQCATRTAIVITPISPVSSAHNLQQLNDQTTTLNKSNLLPPDSG