wanglab/gogpt-training-data huggingface dataset:
Protein: D-ribose pyranase (EC 5.4.99.62) (P04982)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. It also catalyzes the conversion between beta-allofuranose and beta-allopyranose.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Ribose import permease protein RbsC
- Ribose import ATP-binding protein RbsA
- Ribose import binding protein RbsB
- Ribokinase
- Ribose operon repressor
- D-allose-binding periplasmic protein
- Sulfofructose kinase
- D-allose transport system permease protein AlsC
- ABC transporter periplasmic-binding protein YphF
- Autoinducer 2 import system permease protein LsrD
Sequence:
MKKGTVLNSDISSVISRLGHTDTLVVCDAGLPIPKSTTRIDMALTQGVPSFMQVLGVVTNEMQVEAAIIAEEIKHHNPQLHETLLTHLEQLQKHQGNTIEIRYTTHEQFKQQTAESQAVIRSGECSPYANIILCAGVTF
Protein: Serine/threonine-protein kinase KIN28 (EC 2.7.11.23) (P06242)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro. Essential for cell proliferation.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- General transcription and DNA repair factor IIH subunit SSL1
- DNA-directed RNA polymerase II subunit RPB1
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
- General transcription and DNA repair factor IIH subunit TFB1
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor IIE subunit alpha
- General transcription and DNA repair factor IIH helicase subunit XPD/RAD3
- Cyclin CCL1
- RNA polymerase II transcription factor B subunit 3
- General transcription and DNA repair factor IIH subunit TFB4
Sequence:
MKVNMEYTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELPPPSDPSSIKIRN
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q38CJ2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MENYTQLRVLGKGSFGSAWLVQRRSDRVKFVAKEVRLAGLRPAERDSAKREIDLLRTLHHPNITRYVDHFEHRGALYIVMEYADGGDLYSAIRNRRGTRFSEKEILHYFSQLCLAMLHLHEKHILHRDLKTQNVFLTSDGVVKLGDFGISTVLRNTFELKRTVCGTPYYFSPELCLNKPYNNKSDVWALGCILYELTTLTHAFDGNNMKALVQKILKGSYPPIHSSYSTSLSKLISSMLQIDPQRRPSVSEIISSPYIRESLSLLQRVVKDAHNNKGPCQLAGDKERAAAGFKQQEKAQEAPMRAEERRKEEHAKAMHAAKERLQLRMQGEARNRENEEKLRQLKLDQRQAEVEQKIRKQELEARVREQRKLLEKRAKAHALLEKQREEEWERNMREHAEEVRRGQGEEGCARDNRETNAPNDRPCNRYGDGGRRSPLKVPPSPTAAAELYREMRRQAALNKQRFMEEMKVEQPPPAVSGQPNGNGKLPPNRGGNALGNPLGNGQQPQPISPLDDMEARRKAYWDMRREAEENRRRALALEAGPSAVQVEQPEAAPPKESAMPHIVKKPAPQQRPQANDNKPKDVCPLLYAKRTANNEGPPSPQLEPNTPANRVGVYPEVSRADSPDSGTEVKRDEDYNALQTLIDRALTKKGDRESDEDFNDEAFVDSDISRFVLDGRTLVLPKVQATDPLMHRIESLRLFLEGELGESKLLGAYRQMNDISADDDEAMQRVRDELPEAHHKYIPIIAQLIVCEDAFNRQMLR
Protein: Eppin (Cancer/testis antigen 71) (CT71) (Epididymal protease inhibitor) (Protease inhibitor WAP7) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7) (O95925)
Organism: Homo sapiens (Human)
Function: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.
Subcellular location: [Isoform 1]: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.
Interaction partners:
- Semenogelin-1
- Lactotransferrin
- Clusterin
- Kunitz-type protease inhibitor 4
- ETS translocation variant 4
Sequence:
MGSSGLLSLLVLFVLLANVQGPGLTDWLFPRRCPKIREECEFQERDVCTKDRQCQDNKKCCVFSCGKKCLDLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTCKNKRFP
Protein: Early nodulin-like protein 15 (AtENODL15) (Phytocyanin-like protein ENODL15) (Q9SZ51)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:27524487}; Lipid-anchor, GPI-anchor {ECO:0000255}.
Interaction partners:
- At5g38195
- AT3g13990/MDC16_11)
- At4g32110
- Non-specific lipid transfer protein GPI-anchored 31
- Non-specific lipid transfer protein GPI-anchored 7
- SKU5-similar 6
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Embryo-specific protein 3
- Non-specific lipid-transfer protein 6
Sequence:
MASSSLLVTIFLCISVFFFSSVNANEVTVGGKSGDWKIPPSSSFSFNEWAQKARFKVGDFIVFKYEAGKDSVLQVTREAYEKCNTTSPKASYTDGNTKVKLDQAGPVYFVSGTEGHCQKGQKLRLVVITPRNSAFSPGPSPSEFDGPAVAPTSGAAKLAGGFSVVFGLVLGLWAFFF
Protein: Dicarboxylate carrier UCP2 (Mitochondrial uncoupling protein 2) (UCP 2) (Solute carrier family 25 member 8) (UCPH) (P70406)
Organism: Mus musculus (Mouse)
Function: Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (By similarity). Proton transporter activity is debated, but if it occurs it may mediate inducible proton re-entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. Proton re-entry may be coupled to metabolite transport to allow for proton flux switching and optimal ATP turnover (By similarity). Regulates the use of glucose as a source of energy. Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH). This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis. Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation. Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Can unidirectionally transport anions including L-malate, L-aspartate and phosphate (By similarity). Does not mediate adaptive thermogenesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:34644537}; Multi-pass membrane protein {ECO:0000269|PubMed:21785437}. Note=Translocates to mitochondria in macrophages upon IL33 stimulation. {ECO:0000269|PubMed:34644537}.
Interaction partners:
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Leptin
- Peroxisome proliferator-activated receptor gamma
- Peroxisome proliferator-activated receptor alpha
Sequence:
MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGLVRTAASAQYRGVLGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAGIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVEAYKTIAREEGIRGLWKGTSPNVARNAIVNCAELVTYDLIKDTLLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYHSAGHCALTMLRKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMAAYQSREAPF
Protein: Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) (P21275)
Organism: Mus musculus (Mouse)
Function: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Bone morphogenetic protein receptor type-2
- Bone morphogenetic protein receptor type-1B
- Bone morphogenetic protein receptor type-1A
- Chordin
- Noggin
- Activin receptor type-2A
- Activin receptor type-1
- Activin receptor type-2B
- Bone morphogenetic protein 6
- Bone morphogenetic protein 7
Sequence:
MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEEQSQGTGLEYPERPASRANTVRSFHHEEHLENIPGTSESSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWEQGFHRINIYEVMKPPAEMVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGDWAQLRPLLVTFGHDGRGHTLTRRRAKRSPKHHPQRSRKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (B9W6M3)
Organism: Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Interaction partners:
Sequence:
MSGNTVQRNTEQINNALNAIQHRRTTTGNDLNHTNQRIISQNSINDKDYTIYITDDGEKYSTVERAVKSVDPPVTFKPKDEQVFLSNGKPNHQFLKQHFIHEGRLHEHQAIQILKQATHLLSKESNLLNVPAPVTICGDVHGQYYDLMKLFEVGGDPATTKYLFLGDYVDRGSFSIECLLYLYSLKINYPDTFWMLRGNHECRHLTEYFTFKNECLHKYSEQLYEECLVSFNALPLAAIMNEQFFCVHGGLSPQLTSLDSLRKLHRFREPPTKGLMCDLLWADPIEEYDEDNIDQEYVTNVVRGCSFAFTYKAACKFLDKTKLLSVIRAHEAQNAGYRMYKRTKTMGFPSLLTMFSAPNYLDSYNNKAAVLKYENNVMNIRQFNASPHPYWLPHFMDVFTWSLPFVGEKVTDMLVSILNVCTEEELDEDLPFSESEIGVATKTTKTTTPVSPVSPKAHPPSTRITSPYKSTKLVESDNNPNTNNDDSEMTLEEKKQALRNKIIAIGKMSRMFQVLREEQENVAHLKELNRGSLPKGSLLHGVDGLKNTINSFEEAKAADRINEALPPSPEDIQRLKQEKNTRIRQQIENQEMSGPVFQRLIRRLSQS
Protein: EF-hand domain-containing protein (Q57WL4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- T. brucei spp.-specific protein
Sequence:
MSDSESIQFNVMSELESPVVGREGRNACRGESRKPSVKDLKRPPLHGAPSPTSHKSLRRSSGGSSLQFVVCGEAGGDDSDNTDTIQFNVMSELESPVAGREGRNASRGESRKPSVKDLKRPPLHGAPSPTSRKSLRRSSEGSSLQFVVCGEAGGDDSDNTDTIQFQTEGGSRNISLKAASPTSIAGNRRNDSNGRSLRRSSTESGDESVVFVIEDTQSTGGKKPLSRREASNDDTISFVVGDSGGGDEEGADGSSMQKSLSFTVVGSGELPVAPPVFTGKQGSSSPQLMSPLEAPSKPGVGSKDMQRPPKAVSRPKEANNLKGKYRSSSRENTGDGGMTRSDSYDVVEEGGTLKICGTASKHTRAGRLDIPHTTTRGKDVLPPTASEAGKLSPGETRTSTALAPSASALVPLPFPHPSQKKFSLKAADIEEMFLQAKVYTEHWRMFNDIQREEVARLAQRIVEIRDGGSNTAGKMKGKSGEEGKDKPLCFADLFRVKSFLKETDLPWNTERLGNQKKRLPPGRRPAAPAHLVEGGKLPAGRGMSRRDDSGANRRQRPSPQGNKGTRVPKGAKLGVPHFENVAKEMECDAVAQFAEIYGVAWPPSSKNELFFLTGVRLTPKQCEEFYDSMRLYVVASSKVNANMNLLNANERDLSPSRLSDAKRKVRVTRTTLLRKAFTVMDVEKNGVINAALLPSIQRLLEEERRHLQSVLGGDVTPENFLSRSRGEKAKLNGNVETVVSPKVPQNSTAVNAVGTLRIYSLVLDVLLPLLCASGLLTFDFTTVGLLVFGTLSLSTAGASPSFLKWREAAQRCFESLLKNPV
Protein: Dirigent protein 6 (AtDIR6) (Q9SUQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism. Enantiocomplementary dirigent protein that mediates the laccase-catalyzed enantioselective oxidative phenol coupling of (E)-coniferyl alcohol to (-)-pinoresinol.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000305}.
Interaction partners:
- Dirigent protein 10
- Dirigent protein 9
- Dirigent protein 16
- Dirigent protein 18
- Dirigent protein 24
- Dirigent protein 25
- TCP-1/cpn60 chaperonin family protein
- Dirigent protein 4
- Dirigent protein 17
- At1g58270/F19C14_8
Sequence:
MAFLVEKQLFKALFSFFLLVLLFSDTVLSFRKTIDQKKPCKHFSFYFHDILYDGDNVANATSAAIVSPPGLGNFKFGKFVIFDGPITMDKNYLSKPVARAQGFYFYDMKMDFNSWFSYTLVFNSTEHKGTLNIMGADLMMEPTRDLSVVGGTGDFFMARGIATFVTDLFQGAKYFRVKMDIKLYECY
Protein: Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) (P41939)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May function in the production of NADPH for fatty acid and sterol synthesis.
Subcellular location: Cytoplasm.
Interaction partners:
- Aconitate hydratase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase
- Isocitrate dehydrogenase subunit 1, mitochondrial
- Isocitrate dehydrogenase subunit 2, mitochondrial
- Glucose-6-phosphate 1-dehydrogenase
- Citrate synthase 3, mitochondrial
- Citrate synthase, mitochondrial
- Citrate synthase, peroxisomal
- Magnesium-activated aldehyde dehydrogenase, cytosolic
Sequence:
MTKIKVANPIVEMDGDEQTRIIWHLIRDKLVLPYLDVDLKYYDLSVEYRDQTNDQVTVDSATATLKYGVAVKCATITPDEARVEEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRLVPQWEKPIIIGRHAFGDQYKATDVIVPEEGELRLVYKSKSGTHDVDLKVFDYPEHGGVAMMMYNTTDSIEGFAKASFELAIERKLPLYSTTKNTILKKYDGKFKDVFEAMYARSYKEKFESLGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHFRQHQQGKETSTNSIASIFAWTRGIIQRGKLDNTPDVVKFGQILESATVNTVQEDGIMTKDLALILGKSERSAYVTTEEFIDAVESRLKKEFEAAAL
Protein: Protein Lilipod (Q9VC35)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required during oogenesis to promote self-renewal of germline stem cells, probably by enhancing BMP signaling activity.
Subcellular location: Cell membrane {ECO:0000305|PubMed:26512105}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Sequence:
MDEEEEEEVTDLKLQLFHNTVREHIIFLLLIILLYSSSYVVVSRFRRRDRDDLYSNDEDEVLVYRISFWLCTFTLAVAEGAAMLLPVSIASNEVLLLYPNSYYVKWLNSSLIQGLWNHVFLFSNLSLFIFLPFVYLFSESTGFVGNKKGILPRVYETFTVFMLMAIIVLVLTAVLSAVFGIEKLQFFWFLNLGSVHLPFLYSCVSFLGVMLMLICTPYGFVRLFGVVNQVLVRPMLLRDVNEEFSAFYMEEASVKRKLAHIELHNVSIADAANGGRLGNRIGLGRGRTFYPQPLLQHSQAHLYQRKAMASDVDELNDRLRELDSERKELDKLRTSSTFQRTFVYPLAMLLLLFCTAVTILLVVQNTLELLIGIKALPLSTRQFALGISSLSKLGPFGAGLEVCLIFYLGATSVVGFYSMPFMRKVCPKRRQTSLPQLMLNCGFMLVLSSALPLLSRIIGITNFDLLGDFGAIEWLGNFQIVLLYNLVFGTTTALCLANKFTATVRRELRARLVENYVLFTNYISFIN
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (A0A0G2KA94)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Lymphocyte cytosolic protein 2
- Proto-oncogene vav
- B-cell linker protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- Vav guanine nucleotide exchange factor 2
- Vav guanine nucleotide exchange factor 3
- Tyrosine-protein kinase
- Tyrosine-protein kinase
Sequence:
MGLVSACQTPGSAVWPALSPVLCQHALGQESRDLQWQEKEQQKTEMNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLTYYEGRAEKKYRKGFIDISKIKCVEIVKNDDGIIPCQNKFPFQVVHDANTLYIFAPSPQSRDRWVKKLKEEIKNNNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDTHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLPRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEETFGR
Protein: DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1) (Q9NV06)
Organism: Homo sapiens (Human)
Function: Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:24754225, ECO:0000269|PubMed:30283081, ECO:0000269|PubMed:34516797}. Note=In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component. {ECO:0000269|PubMed:24754225}.
Interaction partners:
- U3 small nucleolar RNA-interacting protein 2
- WD repeat-containing protein 36
- Transducin beta-like protein 3
- WD repeat-containing protein 43
- WD repeat-containing protein 3
- U3 small nucleolar RNA-associated protein 4 homolog
- Nucleolar complex protein 4 homolog
- Bystin
- KRR1 small subunit processome component homolog
- WD repeat-containing protein 46
Sequence:
MKVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK
Protein: Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) (P13595)
Organism: Mus musculus (Mouse)
Function: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
- Major prion protein
- Low affinity immunoglobulin gamma Fc region receptor III
- Neural cell adhesion molecule L1
- Tyrosine-protein kinase Fyn
- B-lymphocyte antigen CD19
- Cadherin-2
- Fibroblast growth factor receptor 1
- Alpha-2,8-sialyltransferase 8B
- CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
- Neurotrophic factor BDNF precursor form
Sequence:
MLRTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEFQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRVEPYSSTAQVQFDEPEATGGVPILKYKAEWKSLGEESWHFKWYDAKEANMEGIVTIMGLKPETRYSVRLAALNGKGLGEISAATEFKTQPVREPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVKYRALASEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTAGLSTGAIVGILIVIFVLLLVVMDITCYFLNKCGLLMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPELPADTTATVEDMLPSVTTVTTNSDTITETFATAQNSPTSETTTLTSSIAPPATTVPDSNSVPAGQATPSKGVTASSSSPASAPKVAPLVDLSDTPTSAPSASNLSSTVLANQGAVLSPSTPASAGETSKAPPASKASPAPTPTPAGAASPLAAVAAPATDAPQAKQEAPSTKGPDPEPTQPGTVKNPPEAATAPASPKSKAATTNPSQGEDLKMDEGNFKTPDIDLAKDVFAALGSPRPATGASGQASELAPSPADSAVPPAPAKTEKGPVETKSEPPESEAKPAPTEVKTVPNDATQTKENESKA
Protein: Mannan endo-1,4-beta-mannosidase 5 (EC 3.2.1.78) (Beta-mannanase 5) (Endo-beta-1,4-mannanase 5) (AtMAN5) (Q9M0H6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Bifunctional fucokinase/GDP-fucose pyrophosphorylase
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Glycoprotein 3-alpha-L-fucosyltransferase A
- Dol-P-Man:Man
- Protein trichome birefringence-like 21
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3
- Dol-P-Man:Man
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS2
- UDP-glucose:glycoprotein glucosyltransferase
- Beta-1,2-xylosyltransferase
Sequence:
MVPTRNRPMLRILGFFICAAFIYLSFRDLWLNHKGKAKLGFVKRNGTQFVVDDKPLYVNGWNSYWFMDHAVDEHSRNLVGEMLEAGAKMGLTVCRTWAFNDGGYNALQISPGRFDERVFQALDHVIAEARKHDVRLLLSLVNNLQAYGGKTQYVKWAWQEGVGLSSSNDSFFFDPSIRNYFKNYLKVLLTRKNSVTGIEYRNDPTIFAWELINEPRCTTDVSGKTLQDWIDEMTGFIKSIDDKHLLTVGLEGFYGPNSPKGLTVNPEQWASQLGTDFVQNSNSSNIDFASVHIYPDHWFHNQTFEEKLKFVVKWMQSHIEDGLKELKKPVLFTEFGLSNQNKDYEPSQRDKFYRIIFDVVYKSAKRKKSGAGTLVWQLFMEGMETFNDDFGIVPHEQDSIYKLMIEQSCRLGKVTGRLKEQKLKELCSHRH
Protein: Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) (P54105)
Organism: Homo sapiens (Human)
Function: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Nucleus {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton (PubMed:18984161).
Interaction partners:
- Small nuclear ribonucleoprotein Sm D1
- Methylosome protein WDR77
- Protein arginine N-methyltransferase 5
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein Sm D3
- Small nuclear ribonucleoprotein-associated proteins B and B'
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein G
- Tudor and KH domain-containing protein
Sequence:
MSFLKSFPPPGPAEGLLRQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHALSRDRSDCLGEHLYVMVNAKFEEESKEPVADEEEEDSDDDVEPITEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSIRDYEDGMEVDTTPTVAGQFEDADVDH
Protein: At5g06430 (Thioredoxin superfamily protein) (Q9FNG5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At1g10140
- Amino acid transporter AVT6D
- TATA-box-binding protein 2
- SNF1-related protein kinase regulatory subunit beta-2
- Non-specific lipid transfer protein GPI-anchored 13
- Protection of telomeres protein 1b
- Sucrose nonfermenting 4-like protein
- Serine/threonine-protein kinase GRIK1
- SNF1-related protein kinase regulatory subunit beta-1
- Rhodanese-like domain-containing protein 15, chloroplastic
Sequence:
MESKVTTTSSSTSKDPFFCLKWPWDSNKQPKSSSSVCDFQGPWLFRSMQTIGSIALSSLTSFGQNPNFRPKKKPLSSSEQGEAEQRAFAAALASQKEATVLEFYSHKCRLCNSLLKFVLEVEKRNSNWLSITMADAENEKWFPELLHYDVKYVPCFVLLDKNGQALAKTGVPSSRAHVIAGISHLLKMKRPPSK