Protein: Phosphatidylinositol 4-kinase alpha 1 (PI4-kinase alpha 1ao) (PtdIns-4-kinase alpha 1) (EC 2.7.1.67) (Phosphatidylinositol 4-OH kinase alpha1) (AtPI4Kalpha1) (PI-4Kalpha1) (Q9SXA1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (Probable). Can bind to phosphatidylinositol 4-monophosphate (PI-4-P or PtdIns4P), phosphatidylinositol 4,5-bisphosphate (PI-4,5-P2 or PtdIns4,5P2), and phosphatidic acid (PtdOH), but not to 3-phosphoinositides. May function upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway.
Subcellular location: Membrane {ECO:0000269|PubMed:12805633}; Peripheral membrane protein {ECO:0000269|PubMed:12805633}; Cytoplasmic side {ECO:0000269|PubMed:12805633}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12805633}.
Interaction partners:
- Probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2
- Phosphatidylinositol 4-kinase beta 2
- Phosphatidylinositol 4-kinase beta 1
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1
- Protein NPGR1
- Protein NPGR2
- Phosphoinositide phosphatase SAC6
- Phosphoinositide phosphatase SAC7
- Phosphoinositide phosphatase SAC8
- Hyccin
Sequence:
MEALTELCDIIAKNPKQFSEKLAWICGRCPQTEWLLAESPRVSRSHLNAVLAVARIISKNPESIDNRAKSVVNEFLSAIPASFRRSFWPHSFPSQLISSFYCDFLSYLSCAADLSPEFGTEVARFTGEVVIAAIAPSSGDSDGDPAISKAFLVALSQHFPSILQSDGDKLITMLLDQFVLNRAPASPKEQRQQNSANSETDTSSSQGSPISTNRYPSGKTEMASPGDEVASHGSNLSSKSSSSVVMNGGSIVWKSGVDQLSFGFSEGSGGANPVFRQQVASFEDESIESLEKQEIAFRLITHILDKVKIDSKLQDQVRFIAKRQLQSMSAFLKSRKRDWNEQGQVLKTRVNAKLSVYQAAAKMKIKSLVSLETDGKTSKRLVLETLALLLDAADACLTSVWRKMKACEELFDSLLSGIAKIAVARGGQPLRVLLIRLKPLVLAVCALPDQGAMLESIFKTSCVIIESAWAKDRAPVDNFIMGLASSIRERNDYEEQVDREKQVPAVQLNVIRLLADLNVAVKKPEVADMILPLFIESLEEGDASTPSFLRLQLLDAVSRIATLGFDKSYRETVVLMTRSYLSKLSSVGSVESKTSAPEATTERVETLPAGFLTIASGLMDTKLRSDYRHRLLSLCSDVGLAAESKSGGSGVDFLGPLLPAVAEICSDFDPTMDVEPSLLKLFRNLWFYIALFGLAPPIVKTPTPPLKSTSNSVNSVGSMSATALQAVGGPYMWDNQWALAVQRIAQGTPPLVVSSVKWLEDELELNALHNPGSRRGNGNEKVASTQRLALSTALGGRVDVAAMNTISGVKATYLLAVAFLEIIRFISNGGILNGESSVSASRSAFSCVFEYLKTPNLTPAVSQCLTAIVHRAFETAVSWLEDRISLTGKDARNRELTTYAHACFLIKSMSQRDEHVRDISVNLLTQLRDKFPQVLWHSSCLDSLLFSVHDNTPSTVVNDPAWTAAVRSLYQKVVREWIIISLSYAPCTSQGLLQDKLCKANTWQRAQTTTDVVSLLSEIKIGTGKNELWSGIRTANIPAVMAAAAAASGANLKVSEAFNLEVLGTGVVSATVKCNHAGEIAGMRRLYNSIGGFQSGSTPSGFGGGLQRLISGAFSQAPQPEDDSFNEMLIARFVRLLQQFVNTAEKGGEVEKSQFRETCSQATALLLSNLGGESKTNVEGFSQLLRLLCWCPAYISTPDAMETGIFIWTWLVSAAPQLVSLVLAELVDAWIWTIDTKRGLFASDVRYSGPAAKLRPHLSPGEPEDPPESDPVDQIVAHRLWLGFLIDRFEVVRHNSAEQLLLLGRMLQRSTDLEWCFTRHPAAAGTFFSLMLLGLKFCSCQTQGNMQKFRSGLQLLEDRIYRTSLGWFAHQPEWYDVNIPNFCHSEALSVSVFVHFLSNELSESSQSDSKGKPRESGNLIDVTDQYHPVWGEMDNYTLGKEKRKQLLLMLCQHEADRLDVWAQPISSKDSPYSRLKISSEKWTEYAKTAFSVDPRIALSVASRFPANASVKSEVTQLVQTNIVDLRTIPEALPYFVTPKNVEENSVLLQQLPHWAACSITQALEFLTPAYKGHPRVMAYVLRVLESYPPERVTFFMPQLVQSLRYDDGRLVEGYLLRATQRSDIFAHILIWHLQGEDVQETPKDGSIDKNAAFQEILPQVRQHIIDGFSPNALDMFTREFDFFDKVTSISGVLFPLPKEERRAGIRRELEKIEMQGDDLYLPTAPNKLVRGIRVDSGIPLQSAAKVPIMITFNVIDRDGDHSDVKPQACIFKVGDDCRQDVLALQVISLLRDIFQAAGLNLYLFPYGVLPTGAERGIIEVVPNTRSRSQMGETTDGGLYEIFQQDYGPVGSTTFETARENFLISSAGYAVASLLLQPKDRHNGNLLFDDVGRLVHIDFGFILETSPGGNMRFESAHFKLSHEMTQLLDPSGVMKSKTWHQFVSLCVKGYLAARRQMDGIISTVQMMLESGLPCFSRGDPIGNLRKRFHPEMSEREAAHFMIHVCTDAYNKWTTAGYDLIQYLQQGIEK