wanglab/gogpt-training-data huggingface dataset:
Protein: Polyamine-modulated factor 1-binding protein 1 (PMF-1-binding protein) (Outer dense fiber protein 3) (Q9Z221)
Organism: Rattus norvegicus (Rat)
Function: Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9WVQ0}. Note=Localized at the sperm head-tail connecting piece. During spermatogenesis, it is first observed in the cytoplasm of round spermatids, it later appears in the implantation fossa region of the sperm nucleus during sperm head elongation and differentiation, and finally it localizes to the head-tail connecting piece. {ECO:0000250|UniProtKB:Q9WVQ0}.
Interaction partners:
- Polyamine-modulated factor 1
- Sad1 and UNC84 domain containing 5
Sequence:
MLKLKGEFRTAKGLKDENKKQAQTLVFTDNQVEFKSNKQYHLRQLQQLKKKLLTLQQELEIRTQELQASYRSLLQYQSILEKQTSDLLVLHHHCKLKEDEVILYEEEMGSHSKNTGEKLHLAQEQLALAGDKIVSLERSLNLYRDKYQTSLSNIELLECQVKMLEEELSGLICQDPENKGDHSKVRIYTSPCMIQEHQETLKRLSEVWQKVSEQDDLIQELRNKLACSNSLVLEREEALIKLRADFASYTATHRHPPTSSEDCEDITKILKYLQEQKDSQCLHVEEYQNLVKDLRLELEAVSEQKKKIMKDMMKLELDLHGLREETSCVIEKKDKETVFLQYRLQDLQQQYTESQKLSLKKDKLLQDKDERLNELEKKLTQVQCLFLEKETELEKLQSTTKELDANLQEVRQSTSKIDNEGLRSEIQKLKESLEEAREQLRVSDQNLSQCKDEAHLSANNLEDAHRKLENCLLQDKRKDDVIKDLQSQLQKLQKESSETEEERKNNRQQLLELSSELNEGQRRLSSAEKEKSLLQKTLDEEEKKIDELLHGAKVSEQKQRELTNSLSKLQDELAETKRLLEEKREQLRKSKDQEKALEEEIEALRQESKKKEKMAKEQLRKLEEEKENLQAELSSCSSQLDSSINKYNNSQKVIQELNTEIARQKDSIMILQTQLDSAIQKEKNCFQNMVSKETYEELLRKSGTCQDDLTQALEKLTQATSETKSLQRNLQQTQERKAQLEDEIMAYEERMKKLNMELKKLQGFQQQSELEVHNFDKKLEEMGNQVLQWQRQHQSDLKMLAAKETQLREFQEEMTALKENLLADEKEPSLMPSKPAPKENYRHHRENDQIMCNVEQWAKEQKLANEKLGNKLREQVKYIAKLTGEKDHLHNVMAHLQQENKKLKNEIEEKKLKAGTPRICAKVLGPCKLEPSQKGKLCGALGWRGVCQDPLPKMDLTKYTGVPHCSGSSYC
Protein: Invariant surface glycoprotein, putative (Q57VX3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTMPVTLRTTATVFLLCGICALDVSKASNLPVAYKQYVTINGRKLDGRGALTLCTMKKLLDGVADRADFLERQSWKYLKTVQEIFQKVSEHDDMKAALGEKKLQEMHNVMAISATTGTYVGEAWGKAKRAAANSSKVLKELLKWHCINKEAIRDSFDHMANANCDPSAYKHDYHRNFGHDDARAYVIYCEYKSIPAAKTDVTFSNMEGAVEAWNRAKPKADARDAVECSSGHSSRSASSSDKPCTLLESWRWDYDLAAHCIEKLERYTRNALQTVHYAQKFLHKGKESLAQYLEWKKAAEARAAEEEAKRQAAEKAAEEARKALEEAEARRVAAEEQAEARRLEAEKAEKAKEAGQPVSEEKKKMLLEAVEEAEATEKAAEKQVKDSRKAFEEAEEERVKATEDAEVARWDKEGAEESEEELKKDVEKLAEELKEESKESGEEDDVNADHDDEGSEAKSGWIGTTKVLIFLIPLLLLLLGLLVFFVIRGRRKAEVKDDINIEEANAKSKNTKTAAGFDSDI
Protein: Bicarbonate transporter BicA (Q14SY0)
Organism: Picosynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Function: Low/medium affinity, Na(+)-dependent bicarbonate transporter.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:19951076}; Multi-pass membrane protein {ECO:0000269|PubMed:19951076}.
Interaction partners:
- Polyketide synthase
- SbtA
- CO2 hydration protein
- NhaS3)
- CO2-concentrating mechanism regulator)
- Ribulose bisphosphate carboxylase large chain
- NADH dehydrogenase subunit D4
- NADH dehydrogenase subunit 4
- NAD
Sequence:
MQITNKIHFRNIRGDIFGGLTAAVIALPMALAFGVASGAGAEAGLWGAVLVGFFAALFGGTPTLISEPTGPMTVVMTAVIAHFTASAATPEEGLAIAFTVVMMAGVFQIIFGSLKLGKYVTMMPYTVISGFMSGIGIILVILQLAPFLGQASPGGGVIGTLQNLPTLLSNIQPGETALALGTVAIIWFMPEKFKKVIPPQLVALVLGTVIAFFVFPPEVSDLRRIGEIRAGFPELVRPSFSPVEFQRMILDAAVLGMLGCIDALLTSVVADSLTRTEHNSNKELIGQGLGNLFSGLFGGIAGAGATMGTVVNIQSGGRTALSGLVRAFVLLVVILGAASLTATIPLAVLAGIAFKVGVDIIDWSFLKRAHEISPKGALIMYGVILLTVLVDLIVAVGVGVFVANVLTIERMSNLQSEKVQTVSDADDNIRLTTTEKRWLDEGQGRVLLFQLSGPMIFGVAKAIAREHNAMGDCDALVFDIGEVPHMGVTASLALENAIEEALDKERQVYIVGAAGQTRRRLEKLKLFKRVPPDKCLMSREEALKNAVLGIYPHLADGVTAPSSEMG
Protein: Uncharacterized protein Rv1357c (P9WM07)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Uncharacterized protein Rv1354c
- Probable transcriptional regulatory protein
- Multidomain regulatory protein Rv1364c
- Uncharacterized protein Rv1356c
- Uncharacterized protein Rv1355c
- Uncharacterized protein Rv0894
Sequence:
MDRCCQRATAFACALRPTKLIDYEEMFRGAMQARAMVANPDQWADSDRDQVNTRHYLSTSMRVALDRGEFFLVYQPIIRLADNRIIGAEALLRWEHPTLGTLLPGRFIDRAENNGLMVPLTAFVLEQACRHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVLVEGVLGETGLPAHALQLELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAYLPRLPVDVVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQAARLRAFGCKAAQGWHFAKALPVDFFRE
Protein: Insulin-induced gene 2 protein (INSIG-2) (Q9Y5U4)
Organism: Homo sapiens (Human)
Function: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:32322062}; Multi-pass membrane protein {ECO:0000269|PubMed:12242332}.
Interaction partners:
- Sterol regulatory element-binding protein cleavage-activating protein
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Sterol regulatory element-binding protein 2
- Insulin-induced gene 1 protein
- Sterol regulatory element-binding protein 1
- E3 ubiquitin-protein ligase AMFR
- E3 ubiquitin-protein ligase RNF139
- Probable G-protein coupled receptor 85
- Carbohydrate-responsive element-binding protein
- RING finger protein 145
Sequence:
MAEGETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE
Protein: Epsin-2 (EPS-15-interacting protein 2) (O95208)
Organism: Homo sapiens (Human)
Function: Plays a role in the formation of clathrin-coated invaginations and endocytosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10567358}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:10567358}. Note=In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.
Interaction partners:
- Epidermal growth factor receptor substrate 15
- Intersectin-1
- Clathrin coat assembly protein AP180
- Clathrin heavy chain 1
- Clathrin heavy chain 2
- Intersectin-2
- Huntingtin-interacting protein 1-related protein
- Epidermal growth factor receptor substrate 15-like 1
- Epsin-3
- Phosphatidylinositol-binding clathrin assembly protein
Sequence:
MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPASYHGSPEASLCPQHRTGAPLGQSEELQPLSQRHPFLPHLGLASRPNGDWSQPCLTCDRAARATSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRGDDLRLQMALEESRRDTVKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSASTNQTNPWGGPAAPASTSDPWPSFGTKPAASIDPWGVPTGATVQSVPKNSDPWAASQQPASSAGKRASDAWGAVSTTKPVSVSGSFELFSNLNGTIKDDFSEFDNLRTSKKTAESVTSLPSQNNGTTSPDPFESQPLTVASSKPSSARKTPESFLGPNAALVNLDSLVTRPAPPAQSLNPFLAPGAPATSAPVNPFQVNQPQPLTLNQLRGSPVLGTSTSFGPGPGVESMAVASMTSAAPQPALGATGSSLTPLGPAMMNMVGSVGIPPSAAQATGTTNPFLL
Protein: Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2) (P50222)
Organism: Homo sapiens (Human)
Function: Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:19266028, ECO:0000269|PubMed:22206000}. Nucleus speckle {ECO:0000269|PubMed:19266028}.
Interaction partners:
- Transcription factor 15
- Homeobox protein MOX-1
Sequence:
MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL
Protein: Sorting nexin-16 (P57769)
Organism: Rattus norvegicus (Rat)
Function: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:15292396}; Peripheral membrane protein {ECO:0000269|PubMed:15292396}; Cytoplasmic side {ECO:0000269|PubMed:15292396}. Late endosome membrane {ECO:0000269|PubMed:15292396}; Peripheral membrane protein {ECO:0000269|PubMed:15292396}; Cytoplasmic side {ECO:0000269|PubMed:15292396}. Cytoplasm {ECO:0000269|PubMed:15292396}. Lysosome {ECO:0000269|PubMed:15292396}.
Interaction partners:
- Vacuolar protein sorting-associated protein 26A
Sequence:
MATPYVPVPMPIGNSASSFTNNRNQRSSSFGSVSTSSNSSKGQLEDSSVGTCKHTNVQDQMDSASSVCGSPLIRTKFTGTDSSIEYSARPRDTEEQHPDALNWEDRPSTPTILGYEVMEERAKFTVYKILVKKSPEESWVVFRRYTDFSRLNDKLKEMFPGFRLALPPKRWFKDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPGPFDSLEESRAFCETLEETNYHLQRELLEKQKEVESLKKLLGEKQLHIDALETRIRTLSLEPGASLYVSRAEGGQILRVQSSVLQVNRDVLDEESRADHKPHFNSREAGSAIADIEVAQLAYNAEDD
Protein: Histidine protein methyltransferase 1 (EC 2.1.1.85) (Methyltransferase-like protein 18 homolog C1071.05) (Q9UTQ8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Protein-histidine N-methyltransferase that mediates methylation of target protein on His residues.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
Sequence:
MQANGFSFGFYDEPNNLNGQDVGADSLPSVAIESDSLGHMLKYIPEKLSYARVSGLGHTFVQRELWDVKMQLMEQDDSIESDDKLKVLDGCNDLVPNVYEGGYKTWECSLDLANEIKKIDVVKNNLTTVLELGCGSAIPILSCFQEFYKHRIPCTLVFQDFNVDVLRYVTLPNLLLNWYFCTQEHDSSEKHGTIDVSPSLLQEFSDDLARTNIYCEFLCGCWSEEMQLLIQRTYGDHYFSLVLASETIYSLPSLENFLYMLLKNTKNLALVAGKDLYFGVGGSILEFNSRLQKLVDDPNSLKAIKTSTQNVGRSIVYWEKEFPPSNIDSSPQSPLPGSL
Protein: Pyruvate kinase (EC 2.7.1.40) (V9HWB8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
Protein: Chromatin assembly factor 1 subunit A dimerization domain-containing protein (Q581B8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- 3-hydroxy-3-methylglutaryl coenzyme A reductase
- Chromatin assembly factor 1 subunit B, putative
Sequence:
MDSVAEPLNAPEQGQSEEMKKHPQKVSAPCTAKRKGQKPKTEDNGELQSAGKQKRKKSPAKPPNKVRGGVKTRGMARAESVSKPQPSPEVVNEAPTSEKCNGTGLPSSDDDSEDALVFPSGAPQMKREAAQFNPGLALVRSVIAKIEPPDEITPRITTKRPRSMASGAADKNKKVAVEPPTKVAENSTPTDPVVLSPPSRGLASFGFYTQSKKSTESKASVNKLFTPFVQDKRVSPLSLQFWLPDGPALKRETHVDDVLFLGETSPKSLQSEVCATNNGKVVWAGEEDETHSTQMYQGVGTPYSSFAAMIEHATAHSDTNDGCSAYVTEALRRCPCSFHVQLPPPRKDFCNEIIFCGFYAISFDPCESRPPYFGTYNSQNALNVEELMRLARFGVSEEMPQMSNLDYEYDSGDDWDVADGDEDVGMSGDSNSDEEVDENSSSIVGSDEANNDFINDNDEYDDDSEAEIQRRMFDSRERRRNRLKGREKFVPAFSGPFVAVSALDHPLRDYDKFERISSELNDEVFTTMFEQCLRSCGNVGSSLTTNGNSNCTDVGENQQSFLPHSQQDKRDMTRQEVDILHGIVAANSRISTAKIVTVLLEGGYCVGVSQAEMVRTIRRHYERNHGILVRRVEPWAATDERLFKRRKKQKAGASTANDGDRKEGNDDDDDVQEMSGDDDDMGEEVPLAVTAMEVVCASRDCRSKR
Protein: Uncharacterized protein At2g34460, chloroplastic (Q8H124)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast, plastoglobule {ECO:0000269|PubMed:16461379, ECO:0000269|PubMed:22274653}.
Interaction partners:
- At1g72640
- RNA exonuclease 4
- Histidine-tRNA ligase
- Mannose-P-dolichol utilization defect 1 protein homolog 2
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
Sequence:
MATSLLLRHSSAVFFSQSSFFTKNKSFRSFTSIKMEKGEAENAVKTKKVFVAGATGQTGKRIVEQLLSRGFAVKAGVRDVEKAKTSFKDDPSLQIVRADVTEGPDKLAEVIGDDSQAVICATGFRPGFDIFTPWKVDNFGTVNLVDACRKQGVEKFVLVSSILVNGAAMGQILNPAYLFLNLFGLTLVAKLQAEKYIKKSGINYTIVRPGGLKNDPPTGNVVMEPEDTLYEGSISRDLVAEVAVEALLQEESSFKVVEIVARAEAPKRSYKDLFASVKGQ
Protein: ARS-binding factor 1 (Bidirectionally acting factor 1) (DNA replication enhancer-binding protein OBF1) (SFB-B) (P14164)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: General regulatory factor (GRF) that contributes to transcriptional activation of a large number of genes, as well as to DNA replication, silencing and telomere structure. Involved in the transcription activation of a subset of ribosomal protein genes. Binds the ARS-elements found in many promoters. Binds to the sequence 5'-TCN(7)ACG-3'. Influences on genome-wide nucleosome occupancy and affects chromatin structure, and probably dynamics. As a component of the global genome repair (GGR) complex, promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. Component of the regulatory network controlling mitotic and meiotic cell cycle progression.
Subcellular location: Nucleus {ECO:0000269|PubMed:15522095}.
Interaction partners:
- DNA-binding protein RAP1
- Pre-rRNA-processing protein FHL1
- DNA repair protein RAD16
- DNA repair protein RAD7
- Protein IFH1
- Protein TBF1
- DNA-binding protein REB1
- DNA repair protein RAD4
- Elongin-C
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2
Sequence:
MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ
Protein: Metallothionein expression activator (P21192)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in regulating basal-level expression of CUP1. Activates EGT2 transcription in the absence of SWI5.
Subcellular location: Nucleus.
Interaction partners:
- Serine/threonine-protein kinase CBK1
- Endochitinase
- Fork head protein homolog 2
- Nuclear division defective protein 1
- Pheromone receptor transcription factor
- CBK1 kinase activator protein MOB2
- Cyclin-dependent kinase 1
- Fork head protein homolog 1
- Protein HYM1
- Transcriptional regulatory protein ASH1
Sequence:
MDNVVDPWYINPSGFAKDTQDEEYVQHHDNVNPTIPPPDNYILNNENDDGLDNLLGMDYYNIDDLLTQELRDLDIPLVPSPKTGDGSSDKKNIDRTWNLGDENNKVSHYSKKSMSSHKRGLSGTAIFGFLGHNKTLSISSLQQSILNMSKDPQPMELINELGNHNTVKNNNDDFDHIRENDGENSYLSQVLLKQQEELRIALEKQKEVNEKLEKQLRDNQIQQEKLRKVLEEQEEVAQKLVSGATNSNSKPGSPVILKTPAMQNGRMKDNAIIVTTNSANGGYQFPPPTLISPRMSNTSINGSPSRKYHRQRYPNKSPESNGLNLFSSNSGYLRDSELLSFSPQNYNLNLDGLTYNDHNNTSDKNNNDKKNSTGDNIFRLFEKTSPGGLSISPRINGNSLRSPFLVGTDKSRDDRYAAGTFTPRTQLSPIHKKRESVVSTVSTISQLQDDTEPIHMRNTQNPTLRNANALASSSVLPPIPGSSNNTPIKNSLPQKHVFQHTPVKAPPKNGSNLAPLLNAPDLTDHQLEIKTPIRNNSHCEVESYPQVPPVTHDIHKSPTLHSTSPLPDEIIPRTTPMKITKKPTTLPPGTIDQYVKELPDKLFECLYPNCNKVFKRRYNIRSHIQTHLQDRPYSCDFPGCTKAFVRNHDLIRHKISHNAKKYICPCGKRFNREDALMVHRSRMICTGGKKLEHSINKKLTSPKKSLLDSPHDTSPVKETIARDKDGSVLMKMEEQLRDDMRKHGLLDPPPSTAAHEQNSNRTLSNETDAL
Protein: Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor) (Q9HAV5)
Organism: Homo sapiens (Human)
Function: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
Subcellular location: Membrane; Single-pass type III membrane protein.
Interaction partners:
- Ectodysplasin-A
- TNF receptor-associated factor 6
- TNF receptor-associated factor 3
- TNF receptor-associated factor 1
- Sodium/potassium/calcium exchanger 5
- Membrane-associated transporter protein
- Ectodysplasin-A receptor-associated adapter protein
Sequence:
MDCQENEYWDQWGRCVTCQRCGPGQELSKDCGYGEGGDAYCTACPPRRYKSSWGHHRCQSCITCAVINRVQKVNCTATSNAVCGDCLPRFYRKTRIGGLQDQECIPCTKQTPTSEVQCAFQLSLVEADTPTVPPQEATLVALVSSLLVVFTLAFLGLFFLYCKQFFNRHCQRGGLLQFEADKTAKEESLFPVPPSKETSAESQVSENIFQTQPLNPILEDDCSSTSGFPTQESFTMASCTSESHSHWVHSPIECTELDLQKFSSSASYTGAETLGGNTVESTGDRLELNVPFEVPSP
Protein: Ubiquitin carboxyl-terminal hydrolase-like protein, putative (DUF627 and DUF629) (Q9LZ36)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MEKKEEKFSSVARGLGNYVDALKMINDFSSSAEREESEEFDHLEGEILEYLGKKSTNPALKFTFLLGSVSSFSKLERFPLYAAFSLLNLVREYKSVVYNKMASIYTQKALHFLKPIDRFLAERLTLETLEARIDKGPVPEMPVGSPLIRIRLVPDTEDYERQKSYWLGLDDEGSNFWKVPISEFKTYVEAKTGAVKDLEIVLKYVKKNLKWIAWICRTCSKKFSTRQACHDHLEQEHATGLIPSQRMHMPQRISEDWADKVSSVRDWKPVDAVAAVQMIKDQSAHVKSFVYQDGWCNDWPLATDQVIARSQLLKEIRSLLVTFIQHKVLSDSFRERVVYSLVLKLGISKQKLKDCRLLETPQSICFLECDELNRILVFLRKIKSKRDDGTNLVCQAVDGFLQSSLFRGKISVDLQFSFLLLDKQLLLGELKHYDDEGKLQFLVPSDYYGKVRSRGDAILTWLHDNVNVSQEEDGFVFPKPPDANNYGIWLAVLRAIHLTVSLLVAKIARKKQLVEDSNALHEAQILCQQKKKEKDETKQVLATLLPETSPEFYVAHIDILSKLTDDDDILASIGNLFSGVLEEVAETDSSILLIEKSRIALLGELNQLAFFDYRSYVARHLKKFLLTKL
Protein: Cd209f protein (Q4KL16)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
GSQEKQRMAGEPEFHQSKNHEEEVTSGEQGFAEHDPEGLICSSKSLQGHLTQVPWLLLLLISLGLFLLMLATLVQVSRIRAYSQGQTQDQQGSSSLDKVAVPREQTHSGLEQIQQIQQQLTQFNASLAGLCRPCPWDWELFQGSCYLFSRTLGSWETSASSCEDLGAHLVIVNSVSEQRFMKYWNVRKNQRSWIGLSDHIHEGSWQWVDGSALKFSFWKEGEPNNDGDEDCVELFMDDWNDNKCTEQNFWVCEQPSAPCPHH
Protein: Neurotrophic factor BDNF precursor form (proBDNF) (Brain-derived neurotrophic factor) [Cleaved into: Neurotrophic factor BDNF] (P23363)
Organism: Rattus norvegicus (Rat)
Function: Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P23560}.; SUBCELLULAR LOCATION: [Neurotrophic factor BDNF precursor form]: Secreted {ECO:0000250|UniProtKB:P23560}. Note=A proportion of BDNF is secreted as immature precursor (proBDNF). {ECO:0000250|UniProtKB:P23560}.
Interaction partners:
- High affinity nerve growth factor receptor
- Tumor necrosis factor receptor superfamily member 16
- BDNF/NT-3 growth factors receptor
- NT-3 growth factor receptor
- Sortilin
- Neurotrophin-4
- Glial cell line-derived neurotrophic factor
- Neurotrophin-3
- Ciliary neurotrophic factor
- Cyclic AMP-responsive element-binding protein 1
Sequence:
MTILFLTMVISYFGCMKAAPMKEANVHGQGNLAYPAVRTHGTLESVNGPRAGSRGLTTTSLADTFEHVIEELLDEDQKVRPNEENHKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
Protein: Rhox homeobox family member 2 (Paired-like homeobox protein PEPP-2) (Testis homeobox gene 1) (Q9BQY4)
Organism: Homo sapiens (Human)
Function: Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- DAZ associated protein 2.
- Zinc finger and BTB domain-containing protein 32
Sequence:
MEPPDQCSQYMTSLLSPAVDDEKELQDMNAMVLSLTEEVKEEEEDAQPEPEQGTAAGEKLKSAGAQGGEEKDGGGEEKDGGGAGVPGHLWEGDLEGTSGSDGNVEDSDQSEKEPGQQYSRPQGAVGGLEPGNAQQPNVHAFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRHQRALMARNMLPFMAVGQPVMVTAAEAITAPLFISGMRDDYFWDHSHSSSLCFPMPPFPPPSLPLPLMLLPPMPPAGQAEFGPFPFVIVPSFTFPNV
Protein: Multiple virulence factor regulator MvfR (Transcriptional regulator MvfR) (Q9I4X0)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Transcription regulator that plays a critical role in virulence by positively regulating the expression of multiple quorum sensing (QS)-regulated virulence factors, genes involved in protein secretion, translation, response to oxidative stress and the phnAB operon. At the stationary phase, negatively autoregulates its function through cleavage and translocation to the extracellular space.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:11724939}. Secreted {ECO:0000269|PubMed:11724939}. Note=At stationary phase, gets cleaved and subsequently released in the extracellular space where its transcriptional activity is inhibited. {ECO:0000269|PubMed:11724939}.
Interaction partners:
- Acyl-homoserine-lactone synthase
- Acyl-homoserine-lactone synthase
- Anthranilate--CoA ligase
- HTH-type quorum-sensing regulator RhlR
- 2-heptyl-3-hydroxy-4
- Anthraniloyl-CoA anthraniloyltransferase
- 2-aminobenzoylacetyl-CoA thioesterase
- Transcriptional activator protein LasR
- ATP-dependent RNA helicase RhlB
- Probable FAD-dependent monooxygenase
Sequence:
MPIHNLNHVNMFLQVIASGSISSAARILRKSHTAVSSAVSNLEIDLCVELVRRDGYKVEPTEQALRLIPYMRSLLNYQQLIGDIAFNLNKGPRNLRVLLDTAIPPSFCDTVSSVLLDDFNMVSLIRTSPADSLATIKQDNAEIDIAITIDEELKISRFNQCVLGYTKAFVVAHPQHPLCNASLHSIASLANYRQISLGSRSGQHSNLLRPVSDKVLFVENFDDMLRLVEAGVGWGIAPHYFVEERLRNGTLAVLSELYEPGGIDTKVYCYYNTALESERSFLRFLESARQRLRELGRQRFDDAPAWQPSIVETAQRRSGPKALAYRQRAAPE