wanglab/gogpt-training-data huggingface dataset:
Protein: EP1 procyclin (Q389V1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MAPRSLYLLAILLFSANLFAGVGFAAAAEGPEDKGLTKGGKGKGEKGTKVGADDTNGTDPDPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPGAATLKSVALPFAVAAAALVAAF
Protein: Magnetosome protein MamF (Q2W8R8)
Organism: Paramagnetospirillum magneticum (strain ATCC 700264 / AMB-1) (Magnetospirillum magneticum)
Function: Plays a role in regulating magnetite crystal size; partially redundant function with MmsF.
Subcellular location: Magnetosome membrane {ECO:0000269|PubMed:21414040}; Multi-pass membrane protein {ECO:0000255}. Note=Tagged protein forms straight lines extending along most of the cell associated with its inner curvature, in the correct position to be filaments that are seen associated with magnetosomes. In a mamE disruption MamF mislocalizes as a linear punctate pattern. {ECO:0000269|PubMed:21414040}.
Interaction partners:
- Magnetosome protein MamG
- Magnetosome protein MamC
- Magnetosome protein MamD
- Magnetite biomineralization protein Mms6
Sequence:
MAEAILLETENTPCGCRSYLMAGLSYLGILCFVPLLMSRDDEYVYFHAKQGLVLWMWSVLAMFALHLPLIGKWLFGFSSMGVLVLSVAGLASVALRRTWRLPLVGYFVALI
Protein: RIB72 protein (p72) (Q8LKK4)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000256|ARBA:ARBA00004611}.
Interaction partners:
- Parkin-co-regulated gene product
- Flagellar associated protein
- EF-hand domain-containing protein
- Cilia- and flagella-associated protein 52
- Cilia- and flagella-associated protein 45
- Uncharacterized protein
- CFA20 domain-containing protein
- Cilia- and flagella-associated protein 126
- Uncharacterized protein
- Nucleoside diphosphate kinase
Sequence:
MSGGAPPIPKLPGYTVCLPQSLSDKGFKKGQTLTYVNGYQREDALAQVKDLPERIAQATDGALASGAMGTGVLPASMMQDTATKLPQWVENDRKVLRFYGYFKESVVESNMENHRIRKVILYYYLEDDSMHVAEPRQDNSGIPQGVFIKRHRVTRDDGSFFNPGDFSVGDTVSIYGRNFYLVDADSFTREFMAARGKEQGGPLPYPGDPVDVYRATFGMNRGRAPQAREDSPGSTTRRVNDFKAYVEARLGKPSHLLDGDRLRQFLENNKKVLRFWCVWDERTTMYGDRRPYVLHYYLEDDSVEVLEINENNSGRDPFPVFLKRGPLPKVAVKTNTTLNPKFRKDQCYNAGDFRLGLFINVLGRDFYLHDADTFTKQWYKDNLGYTDEEMSPVDVKEPILPKPRAAVPPFNGYGTIEDSLQNCLSLVPKPPKRDLHKLMNKDKIILRFVVKMVDTDTHKHSATDLARRFILSYFMMDDSNLIFEPPVRNTGIAGGKFLERQKIYKPRSEEIYTYLDLYVGATIEVFNRTFELLEADEYTLTYMENYKDIFVMADTDVLIRSLKAQVSGKEDAVRSSVIAADKSGSGALTGDDLEAGLQSAGLKFTRHQAISLKRRLDKNKTGTISIEEFLGLLGL
Protein: Peptidase A1 domain-containing protein (Q94271)
Organism: Caenorhabditis elegans
Interaction partners:
- Nicastrin
- Gamma-secretase subunit pen-2
- Gut-specific cysteine proteinase
- Cathepsin B-like cysteine proteinase 5
- Aspartic protease 3
Sequence:
MIKTILLLAFVASTSAFVIPFKVHAAVTNITKGGQTLEQTSTFFVANLTMGTPGQLFTVVIDTSTADIVIPDMSCKTANNCYNKRRFNQAKSSSYYAYGNKYTYKNNLGTFQGFDAKDTVVIGDRKTDLITIPGVKFMQATDLGLLMDGLGADGILGLGFTASSQIGGNSPFVQGVNAGDISGTFYSIWLEHFNQTDDLGTHGVIYYGGFDPVHCAPNPTYVPLASAYAYQLTMSSFKVVGSSATNSNNKYIQTYLDTTTAQIGLPKTYISQVFDSLGISTNVMNAIYPTIVPCNTKITLTFGFVSGTTVSITERDLVISFFGTCRLQIIPTTDRIILGLPLYRGRCTYFDPIMQRVGFTPALLQD
Protein: (S)-beta-macrocarpene synthase (EC 5.5.1.17) (Alpha-terpinolene synthase) (EC 4.2.3.113) (Beta-bisabolene synthase) (EC 4.2.3.55) (Beta-myrcene synthase) (EC 4.2.3.15) (Limonene synthase) (EC 4.2.3.16) (Linalool synthase) (EC 4.2.3.25) (Terpene synthase 11) (Q1EG72)
Organism: Zea mays (Maize)
Function: Involved in the biosynthesis of the bicyclic sesquiterpene (S)-beta-macrocarpene. Can use both geranyl diphosphate and farnesyl diphosphate as substrate, but not geranylgeranyl diphosphate. Produces mainly (S)-beta-macrocarpene, but also smaller amounts of beta-bisabolene and (E)-beta-farnesene when used with farnesyl diphosphate as substrate. In the presence of geranyl diphosphate, produces the acyclic monoterpenes beta-myrcene and linalool along with minor amounts of the cyclic compounds limonene, alpha-thujene, sabinene and alpha-terpinolene. May be involved in plant defense.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6Q3H2}.
Interaction partners:
- (S)-beta-macrocarpene synthase (Alpha-terpinolene synthase) (Beta-bisabolene synthase) (Beta-myrcene synthase) (Limonene synthase) (Linalool synthase) (Terpene synthase 6)
- Alpha-humulene/
Sequence:
MAAPTLTTDGPRLGQQEMKKMSPSFHPTLWGDFFLSYEAPTEAQEAEMRQRAEVLREEVRNMIKGSHDVPEIVDLIITLQRLNLDYHYEDEINEKLAVVYNSNYDGGNLDLVSRRFYLLRKCGYHVSSDVFLNFKDQYGNFIEVDTRSLLSLYNAAYLRIHGETVLDEAISFTTRCLQDRLEHLESPIAEEVSSALDTPLFRRVGTLEMKDYIPIYEKDAKQNKSILEFAKLNFNLLQLLYSSELKECTTWWKELRVESNLSFVRDRIVEVYFWMSGGCYDPQYSHSRIILTKIVAFITILDDTLDSHANSYESMQLAEAVERWDESAVSLLPEYMKDFYMYLLKTFSSFENELGPDKSYRVFYLKEAVKELVREYTKEIKWRDEDYVPKTLKEHLKVSLISIGGTLVLCSAFVGMGDVVTKKIMEWVMSDAELVKSFGIFVRLSNDIVSTKREQREKHCVSTVQCYMKQHELTMDEACEQIKELTEDSWKFMIEQGLALKEYPIIVPRTVLEFARTVDYMYKEADKYTVSHTIKDMLTSLYVKPVLM
Protein: Small ribosomal subunit protein bS20c (30S ribosomal protein S20, chloroplastic) (Q9ASV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds directly to 16S ribosomal RNA.
Subcellular location: Plastid, chloroplast {ECO:0000250}.
Interaction partners:
- Large ribosomal subunit protein bL28c
- Large ribosomal subunit protein bL21c
- Large ribosomal subunit protein bL35c
- Large ribosomal subunit protein bL9c
- Large ribosomal subunit protein uL13c
- Small ribosomal subunit protein uS7cz/uS7cy
- Small ribosomal subunit protein bS1c
- Large ribosomal subunit protein uL6c
- Large ribosomal subunit protein uL11c
- Large ribosomal subunit protein bL17c
Sequence:
MATIVQCLSSCATLESQFKVLSLKGISCSSPSSSFSNRRGASATLSSSLSFSQSVSQCVAFSTGNLWVQKPMRQLIVCEAAAPTKKADSAAKRARQAEKRRVYNKSKKSEARTRMKKVLEALEGLKKKTDAQADEIVTVEKLIGEAYSAIDKAVKVKALHKNTGARRKSRLARRKKAVEIHHGWYVPDAAAAAPSEAVPMAA
Protein: Meiotically up-regulated gene 61 protein (O13712)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for correct meiotic chromosome segregation.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
Interaction partners:
- Spindle pole body-associated protein sad1
- Bouquet formation protein 4
- Leucine aminopeptidase 2
- ATP-dependent helicase fft3
- Integral inner nuclear membrane protein ima1
- Uncharacterized protein C2G2.14
- Meiotically up-regulated gene 154 protein
- Charged multivesicular body protein 7
- Bouquet formation protein 3
- Lap-Emerin-Man domain protein 2
Sequence:
MEVPSYFDPDYDPSSLRVVDLRNILTEYQIYYPSTAKKAQLITLFSKLRRAKNGLISMTELQQKNVPPSSRSPRRRVAGVTNNVTARISSKRKINMVDEANDTEISKTSQFEDNVMGMLQDENVQVLNTNTITISEESEFHASKIAKIDSRNEEITHIPFETQTELNAAVVNLDNSMESSFSIVQNLTNKDSSVDTATYDFSAEVGNIVTPASKFLDYDQSYLVNASVSGDPTPVKVLNTTSPKSENPLNQSSFLSFLGENLKPKFTSRSSSVYASPIKSSLNSLECNPSNLLSVRKNFQQSSDSYLKSNKSFDQLNNLVGLSTGNSENFTPENNSFSWTHPKKNSSSPLPQSQSSSIFVEHLNQLYEANASIHRPVNPAFSTNFGLEASNTSTPEKKKFDSQKPDDDSVNEISSDLGLSTTGIDRVEENISLTKDRQPKRPYFSLGSFISLIFSFTKVVNSLWLVLLVVPLLGFVGFWHQEVQRVGFCGVPAEPYPSSLYYLQPGVLRSSIESAYSFAHSLGIEASCQPCPENAECGFNRQLFCKEGLKASFPLLADFGLKPYPRCIPNTVKVNKVEEMVQAFMSIIGKWYYKAPKEFATFESAKNLNGKSFVDNFKDRYYMYKQDIDNVVGLKDFKVYLKTTLNRLYNSKLTRKVLYYLFSPLFTLELWKLRVRGALSKFPTNCLRSVYSHTVSLMKYLTSAVISCWRIYLLIGILAAITGTVVWRIRVYAKKHVVKHGVSVCVSHCIAKLQKTKLKSLTDFSVNPRVEVVQLRSDCFVSGVADDKGLFELVHLPLSIQLEIWEKVVSVLEGMVSVKVWDSERLAKNRAWEWIGVFSDDIAL
Protein: Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3) (Q14123)
Organism: Homo sapiens (Human)
Function: Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
Subcellular location: Lysosome {ECO:0000250|UniProtKB:Q64338}.
Interaction partners:
- Calmodulin-1
- Calmodulin-like protein 3
- Calmodulin-like protein 5
- Calmodulin-like protein 4
- Calmodulin-like protein 6
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
- Guanine nucleotide-binding protein G
- Adenine phosphoribosyltransferase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Sequence:
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLRHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
Protein: Peroxisomal biogenesis factor 5 (F5H0L9)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDDLLAEMQQIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTATDRWYDEYHPEEDLQHTASDF
Protein: Nicotinate dehydrogenase small FeS subunit (NDH) (EC 1.17.1.5) (Nicotinic acid hydroxylase small FeS subunit) (NAH) (Q0QLF3)
Organism: Eubacterium barkeri (Clostridium barkeri)
Function: Catalyzes the hydroxylation of nicotinate to 6-hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs.
Interaction partners:
- Nicotinate dehydrogenase large molybdopterin subunit
- Nicotinate dehydrogenase FAD-subunit
- Nicotinate dehydrogenase medium molybdopterin subunit
- Xanthine dehydrogenase molybdenum-binding subunit
- Xanthine dehydrogenase, molybdenum binding subunit apoprotein
- Xanthine dehydrogenase FAD-binding subunit
- Carbon-monoxide dehydrogenase medium subunit
- Xanthine dehydrogenase accessory factor
- 6-hydroxynicotinate reductase
- Molybdenum cofactor cytidylyltransferase
Sequence:
MNKITINLNLNGEARSIVTEPNKRLLDLLREDFGLTSVKEGCSEGECGACTVIFNGDPVTTCCMLAGQADESTIITLEGVAEDGKPSLLQQCFLEAGAVQCGYCTPGMILTAKALLDKNPDPTDEEITVAMSGNLCRCTGYIKIHAAVRYAVERCAN
Protein: A kinase anchor protein 1 (A-kinase anchor protein 1, mitochondrial) (E7FLX9)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MAIQFRSLFPLALPGMLALLGWWWFFSRKKDPIGSHDKQMEASTVELRASPATEEPLPREDTCPGVAAMPPGLTQPPEKEPTPASKPSVEPSALLRAHAARRRSESSGSLLNSTDTRFRPGALKEDSARVELALAGDEAKPVPLECPLPSPKGVPFPHEAVEECKQESELARTVGQGQQGQSAAPVEPPSPGEKAREMGGAEGTGDAVLGENRLEEGSLSQEPGPELQSSRAPGLAPLGGGGERGRSSPPAAVDQEAVGKLLSGFVESAHVELATADGPAAPRVRGGRACHGDVPRELGREETLDRNEKIEQAAFQIISKVILEATEEVLATTMGRITDRIYQASAGQLQEKKEEESCALASQKTARGHDASEPALAAAEAAVGRADAVLPAADLPAGDLPPPKTYVSCLTSPLSSPTKDRKPKNSAYHMSLAPCPPPAAPLGEAPDEAGVLGEDAACVTCVSNTSQGVPSVASSGQCSDAISMSGLEDSCPETTSSPRDKALTPPLPESAMPFSNGVLKGELSDLGTEDGWTVDVEADHSGGSDGNSMDSVDGCCGPRKPDGFQNAQAGSNPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGSQHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGVDGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDHFSPEADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVIGDEVVLINRSLVERGLAQWVDSYYASL
Protein: Small ribosomal subunit protein bS6 (C3SFQ7)
Organism: Escherichia coli
Interaction partners:
Sequence:
MRHYEIVFMVHPDQSEQVPGMIERYTAAITGAEGKIHRLEDWGRRQLAYPINKLHKAHYVLMNVEAPQEVIDELETTFRFNDAVIRSMVMRTKHAVTEASPMVKAKDERRERRDDFANETADDAEAGDSEE
Protein: IFN signaling evasion protein OPG029 (P17362)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factors 3/IRF3 and 7/IRF7, transcription factors critical for the induction of interferons alpha and beta. This blockage is produced through the inhibition of host TBK1, by binding host TBK1 adapter proteins TBKBP1 and AZI2, thereby producing a strong inhibition of the phosphorylation and activation of IRF3 and IRF7. Acts also as an inhibitor of the cellular response to type I IFN by interacting with host STAT2. Mechanistically, exerts its inhibitory effect after host ISGF3 complex (composed of STAT1, STAT2 and IRF9) binding to the interferon stimulated response element (ISRE).
Interaction partners:
Sequence:
MNAYNKADSFSLESDSIKDVIHDYICWLSMTDEMRPSIGNVFKAMETFKIDAVRYYDGNIYELAKDINAMSFDGFIRSLQTIASKKDKLTVYGTMGLLSIVVDINKGCDISNIKFAAGIIILMEYIFDDTDMSHLKVALYRRIQRRDDVDR
Protein: No-mechanoreceptor potential A short isoform (Q9BMD4)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRPRKGIHVLLTTLVVSLSLSKINGQTTCKNGLGRVLYERLPNQQLQGYDDDVVRDTAPPFRVLEKCQDLCLRDRSGSNNLVRTCTSFDFQPGSRITSFGGNSEYEESLCYLTSEQAGPEGIGSLMLVPNSVHFNEICLTSSRPERECPSRRYVFERHPRKKLKLPISDIKEITAANRSDCEDKCLNEFSFVCRSANFDSTMRSCTLSRFTRRTHPELMEDDPNSDYLENTCLNAERRCDGLAVFVKEENKRLGGPFEVDIFNNMTLEECQTMCLRAEKYFCRSVEFDDQSKQCILSEEDSISQKDDISISSSPTHHFYDLVCLDNQRANDYPDNSVTSHLFSSGRRPDTAFQRYRNSRLGGEFHSEITGRSLSECLDECLRQTSFQCRSAVYSDRFRTCRLSRYNQKDGMRIIYDADYDYYENLMLNVVGGGADGDGGGHGGSSDGKRPGDQSGSNWRQPNKHDDRYGSGGSSVGGGSHGGTGSGGSRLPPGEGVDYGRPYDRYPDIAGNEYDRNPYGGDRDRDRYPPDRYGSRYPTGGDGIGYNRPYDRFPDDYDRYPAGAGVNGDRDRERDRDRYPVVGDRDRYPGAVDRDRYPGVRDRXRYPEPYPPERYXDRYGDRRYPERERDRDRDRLPYRPLPYPGINDNSLPSDLPHTRPYPTDDDAPFRPYGYGGGRYGENRYEGRYPPRFPPSRERDPVGGYTGRDAPDSIFPDRRYRPSSMDSPRYPYLPDSRGPPGRYDDIVHSARRPEPDSAKRYPPAPIAPTGSSSKYASTPNRFPVGNDRYPIDIYKYGNRPGPNDLGRRPGLERPPPPFYDYDYEERYGDRYGPYDREYDGPPGRRPPSGGPYGRYDSPFNRPYGGNGLDDRPLPLPGLGLSHPPTPYGGGGAGHVGVGVGVNSGPPRPPITRCEESDNFKQIAARHKMRRHFVRRALIVPSLIQCERECIESRDFVCRSFNYRDSAASGYEDRDRDRDRDSPNCELSDRDSRELDIHDPGTFDASNYDFYERSIGRSDGECMDVTQTCNEEGMEFTIRTPEGFLGRIYTYGFYDRCFFRGNGGTVNVLRLSGPQGYPDCGTQRYGDTLTNIVVVQFSDNVQTSRDKRYNLTCIFRGPGEAVVSSGYIGAGSGSPIPIEYLPAENTLSSKVRLSILYQGRPTTTIAVGDPLTFRLEAQDGYNHVTDIFATNVVARDPYSGRSIQLIDRFGCPVDPFVFPELDKLRDGDTLEARFNAFKIPESNFLVFEATVRSCREGCQPAYCPGPAGRQEPSFGRRRRSLNTTEIPEPEALALEGSSQLEASTLDEVTVVNSTTVSATLGQVPLNETQLGEKTKETEEPEQVREMIEVFETREEIEKESYPRKLVAPVETVCMTPAEYHGLITAIILLMILLFSITLVAGLGYRRYWKSISKNRLVDRHSPIHSLGHSHSSIRTHERFTEIGHMPNLNGGGGGAAAGTGGGANQSASNRASNAFRTNMSMFGGSLHKTFATGNLARMCQLPVINPMRSTNQSSHQFEDPSEPIYTDPSLFERSRSLRSLTMVAESEDNQEV
Protein: Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB) (Q9WUF4)
Organism: Rattus norvegicus (Rat)
Function: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (By similarity). Also required for dense-granule secretion in platelets (By similarity). Also plays a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (By similarity).
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:10982406}; Single-pass type IV membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:10982406, ECO:0000269|PubMed:11029036}; Single-pass type IV membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:11029036, ECO:0000269|PubMed:9614193}; Single-pass type IV membrane protein {ECO:0000305}. Midbody {ECO:0000269|PubMed:12737809}. Cell membrane {ECO:0000250|UniProtKB:O70404}; Single-pass type IV membrane protein {ECO:0000305}. Zymogen granule membrane {ECO:0000250|UniProtKB:O70404}; Single-pass type IV membrane protein {ECO:0000305}. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (PubMed:9614193). Sub-tight junctional domain in retinal pigment epithelium cells (PubMed:11029036). Midbody region during cytokinesis (PubMed:12414999). Lumenal oriented, apical membranes of nephric tubular cell (PubMed:11208143). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250|UniProtKB:O70404, ECO:0000269|PubMed:11029036, ECO:0000269|PubMed:11208143, ECO:0000269|PubMed:12414999, ECO:0000269|PubMed:12737809, ECO:0000269|PubMed:9614193}.
Interaction partners:
- Syntaxin-7
- Synaptosomal-associated protein 23
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Syntaxin-4
- Syntaxin-8
- Synaptosomal-associated protein 29
- Syntaxin-17
- Syntaxin-5
- Syntaxin-6
- Syntaxin-7
Sequence:
MEASGSAGNDRVRNLQSEVEGVKNIMTQNVERILARGENLDHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVIICVIVLIILILIILFATGTIPT
Protein: Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) (O95747)
Organism: Homo sapiens (Human)
Function: Phosphorylates RELL1, RELL2 and RELT. Phosphorylates PAK1. Phosphorylates PLSCR1 in the presence of RELT.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:22361696, ECO:0000269|PubMed:22989884}.
Interaction partners:
- RELT-like protein 2
- Tumor necrosis factor receptor superfamily member 19L
- Solute carrier family 12 member 2
- Serine/threonine-protein kinase WNK1
- Protein transport protein Sec61 subunit gamma
- Translocation protein SEC62
- Serine/threonine-protein kinase WNK4
- RELT-like protein 1
- Solute carrier family 12 member 3
- Calcium-binding protein 39
Sequence:
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
Protein: Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2) (Q8TE23)
Organism: Homo sapiens (Human)
Function: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Taste receptor type 1 member 3
- Taste receptor type 1 member 1
- Sodium/glucose cotransporter 1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Taste receptor type 2 member 4
- Taste receptor type 2 member 38
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- Taste receptor type 2 member 3
Sequence:
MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQLLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD
Protein: Formin-like protein 8 (AtFH8) (AtFORMIN-1) (O04532)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Might be involved in the organization and polarity of the actin cytoskeleton. Interacts with the barbed end of actin filaments and nucleates actin-filament polymerization in vitro.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16313636}; Single-pass membrane protein {ECO:0000269|PubMed:16313636}.
Interaction partners:
- Profilin-4
- Profilin-3
- Profilin-2
- Profilin-5
- Profilin-1
- Formin-like protein 12
- KRR1 small subunit processome component
- FH protein interacting protein FIP2
Sequence:
MAAMFNHPWPNLTLIYFFFIVVLPFQSLSQFDSPQNIETFFPISSLSPVPPPLLPPSSNPSPPSNNSSSSDKKTITKAVLITAASTLLVAGVFFFCLQRCIIARRRRDRVGPVRVENTLPPYPPPPMTSAAVTTTTLAREGFTRFGGVKGLILDENGLDVLYWRKLQSQRERSGSFRKQIVTGEEEDEKEVIYYKNKKKTEPVTEIPLLRGRSSTSHSVIHNEDHQPPPQVKQSEPTPPPPPPSIAVKQSAPTPSPPPPIKKGSSPSPPPPPPVKKVGALSSSASKPPPAPVRGASGGETSKQVKLKPLHWDKVNPDSDHSMVWDKIDRGSFSFDGDLMEALFGYVAVGKKSPEQGDEKNPKSTQIFILDPRKSQNTAIVLKSLGMTREELVESLIEGNDFVPDTLERLARIAPTKEEQSAILEFDGDTAKLADAETFLFHLLKSVPTAFTRLNAFLFRANYYPEMAHHSKCLQTLDLACKELRSRGLFVKLLEAILKAGNRMNAGTARGNAQAFNLTALLKLSDVKSVDGKTSLLNFVVEEVVRSEGKRCVMNRRSHSLTRSGSSNYNGGNSSLQVMSKEEQEKEYLKLGLPVVGGLSSEFSNVKKAACVDYETVVATCSALAVRAKDAKTVIGECEDGEGGRFVKTMMTFLDSVEEEVKIAKGEERKVMELVKRTTDYYQAGAVTKGKNPLHLFVIVRDFLAMVDKVCLDIMRNMQRRKVGSPISPSSQRNAVKFPVLPPNFMSDRAWSDSGGSDSDM
Protein: Tubulin-specific chaperone B (Alpha-tubulin formation protein 1) (Tubulin-folding cofactor B) (P53904)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts to sequester alpha-tubulin from interaction with beta-tubulin, raising the possibility that it plays a regulatory role in the formation of the tubulin heterodimer.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
Interaction partners:
- Protein PAC2
- Tubulin-specific chaperone A
- Chromosome instability protein 1
- GTP-binding protein CIN4
- Tubulin-specific chaperone C
- Tubulin alpha-1 chain
- Tubulin alpha-3 chain
Sequence:
MVRVVIESELVRTEKELPNSLKLRQFKDRLYHVTGVEPEDMEIVVKRQYDNKEIYSTKKGGAYSNEDEDANFLKGEEELIVVVTDSNAQSISNQLATQAEGIPSMEVISEEDYLRRDQSVLRWKMAHGYGRFNAAQQSQRAALAKQDEAYAREQLTAAIGRHCRVTVDGSAPREAILRYVGPLPLDVMGTWCGVEFPEAAGKNDGRINGVTLFGPVAPGHGSFVRPRAVEILSKDEESAEVEDVHDDVESDDEI
Protein: Putative glucokinase-2 (EC 2.7.1.2) (Early meiotic induction protein 2) (Glucose kinase 2) (GLK-2) (Q04409)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Putative glucokinase involved in phosphorylation of aldohexoses and glucose uptake (By similarity). Involved in sporulation. Required for the full activation of the early meiotic inducer IME1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Glucose-6-phosphate isomerase
- Glucose-6-phosphate 1-dehydrogenase
- Phosphoglucomutase 2
- Invertase 2
- Glucokinase-1
- ATP-dependent 6-phosphofructokinase subunit alpha
- Mannose-6-phosphate isomerase
- Fructose-1,6-bisphosphatase
- ATP-dependent 6-phosphofructokinase subunit beta
- Phosphomannomutase
Sequence:
MSFENLHKVNAEALEDAVVEICSSLQVDAAKLDELTAYFIECMEKGLNNTSVGEEKTVDKGLPMIPTYVTSLPNGTERGVLLAADLGGTHFRVCSVTLNGDGTFDMQQLKSKIPEEYLNDKDVTSEELFSYLGRRTRAFVRKHHPELLKSTGENIKPLKMGFTFSYPVDQTSLSSGTLIRWTKSFKIEDTVGKDVVRLYQEQLDIQGLSMINVVALTNDTVGTFLSHCYTSGSRPSSAGEISEPVIGCIFGTGTNGCYMEDIENIKKLPDELRTRLLHEGKTQMCINIEWGSFDNELKHLSATKYDIDIDQKFSPNPGYHLFEKRISGMYLGELLRNILVDLHARGLILGQYRNYDQLPHRLKTPFQLCSEVLSRIEIDDSTNLRETELSFLQSLRLPTTFEERKAIQNLVRSITRRSAYLAAVPIAAILIKTNALNKRYHGEVEIGFDGYVIEYYPGFRSMLRHALALSPIGTEGERKIHLRLAKDGSGVGAALCALVA
Protein: Thyroid hormone receptor beta (J3KR21)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRC