wanglab/gogpt-training-data huggingface dataset:
Protein: DNA double-strand break repair Rad50 ATPase (EC 3.6.-.-) (Q9X1X1)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).
Interaction partners:
- Exonuclease, putative
- DNA-directed DNA polymerase I
- Hypothetical protein
- ATP-dependent protease LA
- Hypothetical protein
- Conserved hypothetical protein
- Dihydrofolate reductase
- Glutamate synthase, beta subunit
- Dihydroorotate dehydrogenase B
- ABC transporter, ATP-binding protein
Sequence:
MRPERLTVRNFLGLKNVDIEFQSGITVVEGPNGAGKSSLFEAISFALFGNGIRYPNSYDYVNRNAVDGTARLVFQFERGGKRYEIIREINALQRKHNAKLSEILENGKKAAIAAKPTSVKQEVEKILGIEHRTFIRTVFLPQGEIDKLLISPPSEITEIISDVFQSKETLEKLEKLLKEKMKKLENEISSLQALYTAIWKYLEENDLEVLKSELKTVSEKKKELLKKREELQKEEEQLKRLLEKYRELVKKKERLRVLSLRRNELQKEVIYEQKVKKAKELEPLFREIYLRQREFERFSQELNSREKRYKELESEKEAISKEIPVHRERLSKLEEIGEKIKEELDLLEKVLKASRPLLEQRIRLKENLTRLEEEFRRLVGEKEKREKELLSIEKTENETKNELEKLLDELSILKKDHMKWLAYQIASSLNEGDTCPVCGGVFHGKVEAVEFNIDEFEKLDQKRSELENTLNVLKERKKSLSSLIEDLLMKIEEGKKNLKSIRNQIEKIEEELHRLGYSEDLEEKLDEKRKKLRKIEEERHSISQKITAADVQISQIENQLKEIKGEIEAKRETLKEQREEMDQLKSDFFDRLRKIGIGFEEFRILVKEEVKDAEKELGVVETEIRLLEESLKELESENVRDVSEDYEKVRNQLEALSQEISDLERKEGRLNHLIEETLRRERELKSLEKKLKEMSDEYNNLDLLRKYLFDKSNFSRYFTGRVLEAVLKRTKAYLDILTNGRFDIDFDDEKGGFIIKDWGIERPARGLSGGERALISISLAMSLAEVASGRLDAFFIDEGFSSLDTENKEKIASVLKELERLNKVIVFITHDREFSEAFDRKLRITGGVVVNE
Protein: Uncharacterized protein (Q389E1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MVLWVVIFSLAGAELENYSTVISNVAFSALLSFTMPMQLAELRSMLLELVLGPDDDGKVERNKEADVEGSRKLKEMLMLLGAIILGAVVTQLDWAVWFQRWPLPSVVLYSIVRALLYYSGKTPEKVDEKVE
Protein: Rifin (Q8IK42)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHYFNILLFPFSLNIMLLSSQVYNQRNHYITLHMPNTESIKRHRSLCECDLYMPNYDNDPQMKEVMDNFNKQTQQRFNEYDDRMNEKRQKRKEQRDKNIDEIIKKDRMDKSLAEKVEKCCLICGCGLGGVAASVGIFGTVAVKELTKAAITTATELAKEEAMVEGVAKGAAAGKEFVIAKLQEMGISTLRGNVFETLFTAQNYNNVKTIALAINTQYDASSCPIHGSGPSETFCALVNQKSVAALKVQRMTQGGAVSTYEVIETAVKPIVSEAETVAAAAAKKATEEAIKASTEAVESAYAACQTAIIASVVAILVIVLVMMIIYLILRYRRKKKMNKRAQYTKLLNQ
Protein: Trinucleotide repeat containing 18 (H9KVB4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDGRDFGPQRSVHGPPPPLLSGLAMDSHRVGAATAGRLPASGLPGPLPPGKYMAGLNLHPHPGEAFLGSFVASGMGPSASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPSYLHLNHLEPPSSGSPLLSQLGQPSIFDTQKGQGPGGDGFYLPTAGAPGSLHSHAPSARTPGGGHSSGAPAKGSSSRDGPAKERAGRGGEPPPLFGKKDPRARGEEASGPRGVVDLTQEARAEGRQDRGPPRLAERLSPFLAESKTKNAALQPSVLTMCNGGAGDVGLPALVAEAGRGGAKEAARQDEGARLLRRTETLLPGPRPCPSPLPPPPAPPKGPPAPPAATPAGVYTVFREQGREHRVVAPTFVPSVEAFDERPGPIQIASQARDARAREREAGRPGVLQAPPGSPRPLDRPEGLREKNSVIRSLKRPPPADAPTVRATRASPDPRAYVPAKELLKPEADPRPCERAPRGPAGPAAQQAAKLFGLEPGRPPPTGPEHKWKPFELGNFAATQMAVLAAQHHHSRAEEEAAVVAASSSKKAYLDPGAVLPRSAATCGRPVADMHSAAHGSGEASAMQSLIKYSGSFARDAVAVRPGGCGKKSPFGGLGTMKPEPAPTSAGASRAQARLPHSGGPAAGGGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLGPGLVDQERSLSLSNVKGHGRADEDCVDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAPNGLNPNLMVTGGPALAGSGRWSADPAAHLATHPWLPRSGNASMWLAGHPYGLGPPSLHQGMAPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERATVPPLWPALYPPGRSPLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVQERLKAQEHRAEMEEKGSKRGLEAAGKAGLATAGPGLLPRKPPGLAAGPAGTYGKAVSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPTSPPPASPPPTPGITRKEEAPENVVEKKDLELEKEAPSPFQALFSDIPPRYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPIRLSPSKITEPLREGPEEEPLAEREVKAEVEDMDEGPTELPPLESPLPLPAAEAMATPSPAGGCGGGLLEAQALSATGQSCAEPSECPDFVEGPEPRVDSPGRTEPCTAALDLGVQLTPETLVEAKEEPVEVPVAVPVVEAVPEEGLAQVAPSESQPTLEMSDCDVPAGEGQCPSLEPQEAVPVLGSTCFLEEASSDQFLPSLEDPLAGMNALAAAAELPQARPLPSPGAAGAQALEKLEAAESLVLEQSFLHGITLLSEIAELELERRSQEMGGAERALVARPSLESLLAAGSHMLREVLDGPVVDPLKNLRLPRELKPNKKYSWMRKKEERMYAMKSSLEDMDALELDFRMRLAEVQRQYKEKQRELVKLQRRRDSEDRREEPHRSLARRGPGRPRKRTHAPSALSPPRKRGKSGHSSGKLSSKSLLTSDDYELGAGIRKRHKGSEEEHDALIGMGKARGRNQTWDEHEASSDFISQLKIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDSAGGKSKTSGGCGRYLTPYDSLLGKNRKALAKGLGLSLKSSREGKHKRAAKTRKMEVGFKARGQPKSAHSPFASEVSSYSYNTDSEEDEEFLKDEWPAQGPSSSKLTPSLLCSMVAKNSKAAGGPKLTKRGLAAPRTLKPKPATSRKQPFCLLLREAEARSSFSDSSEESFDQDESSEEEDEEEELEEEDEASGGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLLGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPSLAAPTPGARGPDPSSPDKAKLAVEKGRKARKLRGPKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAAPAPVSTAPATKTSRCAKGGPLSPRKDAGRAKDRKDPRKKKKGKEAGPGAGLPPPRAPALPSEARAPHASSLTAAKRSKAKAKGKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAVERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTVHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRFLPQGTRIAAYWSQQYRCLYPGTVVRGLLDLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGRGRKPSAKAKGGRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGNNMVVRVKWFYHPEETSPGKQFHQGQHWDQKSSRSLPAALRVSSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLKTKKYQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC
Protein: Innate immunity activator protein (Q3KP66)
Organism: Homo sapiens (Human)
Function: Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.
Subcellular location: Nucleus {ECO:0000269|PubMed:28436939}. Cytoplasm {ECO:0000269|PubMed:28436939}. Note=Translocates to the nucleus upon NOD2 stimulation. {ECO:0000269|PubMed:28436939}.
Interaction partners:
- Cytohesin-2
- Cytohesin-1
- Cytohesin-3
Sequence:
MLQMPKLNEIPPGRAGRREARGEGRWPGQTGPEAARLEWRAQGQAGGARAPWDSWGSSRLPTQPGPGWSRCPPSLLCALSFQKSTMESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVAHHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRIVRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSTRPHSLDRQGAFRVRSLPLGREGFGRALGPRAQVPTVCVLRRSPDGAPVQVFVPEKGEIISQV
Protein: Syntaxin-related protein KNOLLE (Syntaxin-111) (AtSYP111) (Q42374)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in cytokinesis. Acts as a cell plate-specific syntaxin, required for the fusion of vesicles at the plane of cell division.
Subcellular location: Membrane; Single-pass type IV membrane protein.
Interaction partners:
- SNAP25 homologous protein SNAP33
- Novel plant SNARE 11
- Putative SNAP25 homologous protein SNAP30
- SNAP25 homologous protein SNAP29
- UPF0235 protein At5g63440
- SNARE-interacting protein KEULE
- Vesicle-associated membrane protein 721
- VAMP-like protein YKT62
- Syntaxin-32
- Syntaxin-31
Sequence:
MNDLMTKSFMSYVDLKKAAMKDMEAGPDFDLEMASTKADKMDENLSSFLEEAEYVKAEMGLISETLARIEQYHEESKGVHKAESVKSLRNKISNEIVSGLRKAKSIKSKLEEMDKANKEIKRLSGTPVYRSRTAVTNGLRKKLKEVMMEFQGLRQKMMSEYKETVERRYFTVTGEHANDEMIEKIITDNAGGEEFLTRAIQEHGKGKVLETVVEIQDRYDAAKEIEKSLLELHQVFLDMAVMVESQGEQMDEIEHHVINASHYVADGANELKTAKSHQRNSRKWMCIGIIVLLLIILIVVIPIITSFSSS
Protein: Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-) (Q8R127)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MATEQRPFHLVVFGASGFTGQFVTEEVAREQIASEQSSRLPWAVAGRSKEKLQQVLEKAAQKLGRPSLSSEVGVIICDISNPASLDEMAKQAKLVLNCVGPYRFYGEPVVKACIENGTSCIDICGEPQFLELMHAKYHEKAAEKGVYIIGSSGFDSIPADLGVLYTRNQMNGTLTAVESFLTINTGPEGLCIHDGTWKSAIYGFGDKGSLRKLRSVSCLKPVPIVGTKLKRRWPVSYCRELNSYSIPFLGSDISVVKRTQRYLHENLEDSPVQYAAYVTVGGITSVIKLMFAGLFFLFFVKFSIGRQLLIKFPWLFSFGYFSKQGPTQKQMDETSFTMTFFGQGYSHGTCVEKNKPNIRICTQVKGPEAGYVATPIAMVQAAMTFLSDASDLPKGGGVFTPGAAFSRTKLIDRLNKHGIEFSVISSSEV
Protein: Neamine phosphoribosyltransferase (EC 2.4.2.49) (Butirosin biosynthesis protein P) (Q4H4F7)
Organism: Niallia circulans (Bacillus circulans)
Function: Catalyzes phosphoribosylation of neamine using 5-phosphoribosyl-1-diphosphate (PRPP) as a phosphoribosyl donor to generate 5''-phosphoribostamycin in the biosynthetic pathway of butirosin.
Interaction partners:
Sequence:
MKDNPISLFHELESYVRGSKDTLHRYMYACILEQRLADLLLLSRCGVHPDDEDRLAVRLASQRSLCVQAASDLAEGTEEARGSTPAWPDCKVTKSSAAQKRPELLSLVKVMQELRTPECSGYDLCDLEVCREDALHWLRDHADPSSPPVLIGVRTGGAFYAPLWSSALQQRWGNKALYHTVRALRMPSDPGASLYLPEELSILPAAIEPDTDIVILEDQPHTGGTVLELAGRLSAKYRLNKPVWVSSPGRLFQIENGRLAKCSDRIPLNTGTRKRIWQMLGNSEEVAEFLLPKLGLTDAHPADLEAVPYKSVPQWNDPMYRREVPFRINPKKTPFYIRRKSTNEPVVFAKFIGKDLFGDFQFHQLKKFEKYFPDILAYQDGYVMTKYEPGLKEMREMFVNMPSAVTREICQSVSGYWKTLLDSCQISGGHPVHPLADHWQARLGEMEDFIGRKLPYDLDWFERSLHTEWTSSAHVYTSLPYANQYGHWKARLSAGQRLKTYRFHIDSTWGGTSSIEVELASFLLENRVRPDDFRLLVNQVKKEAGSLTIEAVTDALPIACVLQAANLLKQAKDESRLSKELILSEAMQSFEYLQAMKPKLSDVR
Protein: NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28) (Q8VCM2)
Organism: Mus musculus (Mouse)
Function: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17140397}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NFA2}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8NFA2}. Note=Associates with the plasma membrane in a lipid-dependent manner. {ECO:0000250|UniProtKB:Q8NFA2}.
Interaction partners:
- NADPH oxidase activator 1
- Cytochrome b-245 light chain
- Neutrophil cytosol factor 2
- NADPH oxidase 1
- Neutrophil cytosol factor 4
- NADPH oxidase 3
- Neutrophil cytosol factor 1
- Ras-related C3 botulinum toxin substrate 1
- NADPH oxidase 2
- Ras-related C3 botulinum toxin substrate 2
Sequence:
MASPRHPVSAHAVALVQMDRLQTFAFSVCWSDNSDTFVRRSWDEFRQLQKTLKKTFPVEAGLLRRSEQVLPKLPDAPLLTRRGHTGRGLVRLRLLDTYVQALLATSEHILRSSALHGFFVPKPLDLEPMLPPGSLVILPTPEEPLSQPRGSLDIHSLEAQSIPCVQPFHTLDIRDRPFHTKAQEILDILLRHPSGWWLVENKDQQVAWFPAPYLEEVATCQGQESGLALQGSGRQFCTTQAYEGSRSDELSVPSGARVHVLETSDRGWWLCRYNGRTGLLPAMSLQPEGLGSLLGRPGFPDSAGADKVAEDRTIPPVVPTRPCMSAIQSRCCSITRRALGQEQGTRVPR
Protein: Ofi1p (A0A1D8PFN2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Opaque-phase-specific protein OP4
- Mrv2p
- Uncharacterized protein
- [histone H3]-trimethyl-L-lysine
Sequence:
MNSNSNDEQIQNVNEPVRPRLPSIQQLTNGHIFHQGGNPSHPTDIIIPAVKSPIGGAQSSAIHMPEVQDLQQQQRLQNVNEQLQATPSVKQRLVKRYFCKICAQGFTRKHNMVSHELIHSSLKPHICQVCNLRFRRIHDLKRHEKLHTGEKPYSCSKCLRSFARPDALTRHQNSQNACTGSASVTANSRSDPQTLQTSSSNQSEIITNGNTSPGGINEKSVDSNIANGSSVHINSSSGHREINNQPSHSNSLPVENNEPISPHQLQHPQQHPRIRQLSLPQLQSKSQFPFTNTYYHPPHVPPQAQSYSQINRQPMQTPPSAVPQGGNTSIQNQPNTQPSSLQNQRPPVVYPTNTSFSPSQFSSSTHNLPYYYPYPAYNHYPPPPPPAPSQLLPPFQFQQQQQLGPQSLPVVPLPPHTAPPSLSLTASTQLQTYHQHQNPNDPSKRPLRNSTGDISSVSNLPQTAVIHESKSVASESNPTTTKQQYPPSQNQPYSFGGGGGDPAYPPPLPITNPPHQSAIITTSGSSSTLHPPLNQQIFSSHPSNENVNPPHNTLLHSGSTNRQMDTMPLQGSGGRPVQIAPSSVPPGPRSAPSTAISIPSHNGPQYIPYENYQELYNYTQSLQQSINYLSGNLQKLEDRKSGSDEKPL
Protein: Putative hydrolase C777.06c (O74545)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable octanoyltransferase
- Lipoyl synthase, mitochondrial
Sequence:
MTKGTSKLLFMGTGCSSGIPNVCCLTLEKPTCRTCLASLTPEGRKNNRFNTSVLLQVDDGSGDRPKNILIDCGKHFYVSALKHFVEHKIRYLDAVILTHDHADAINGMDDLREWTLGFLQPSVKIYLTERTYKVIERSFPYMVNAKNATGGGSVPTFDFHVFSPDKPFKLDDIDISVTPLPVHHGVYFIEGKESQTYFCMGFRVGDMSYISDCNYVPPTTKKLMEGSNVVVVDALKHEPYPSHFSFKQAEEFIASLEHVPSRVLYTGFSHKVEHNETVKELSVLKVPTEPAYDGQIVEFHV
Protein: Uncharacterized protein (Q57WD5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTPVFGTAAFFCRLRSSSLRRFCLNHQRRARSSGSSIGIAHEVTSLHPYGCSNNVVGSTRVWNETENWCSLCLEPLNSWSEHRGKRDHICLEMFYNAITQYGRRWSPSTLWWEVEECTLLRRHASPRLVLDGGEGFFSGCILDYVRDSTGKRGGLSLLMDYYDRMEHYKRRLELYACIQHLIDNGIVRTDRGSLGGGASFHGSLVTFKELFPNLVNMFPFADAKEISALTQMIASTYNGETVFDLCNFQGLLPAGQGGGDTTGGKGNTSGCGNSQQRLAFNAEQKGSEDSSVTASAEGVYSYHWKGMFCRGVMGQLRWALECDSVACPLKRADGSKHVCDPYWQVLSEYTCRALLAEMVFCRVSEYIVRVEGVWRKCGQELANKHVSHGSQKEEEERAHPPRTSNWGYIRYMGDHLYDDMFGGNLPNEGAPKRLSLMR
Protein: WD repeat-containing and planar cell polarity effector protein fritz homolog (hFRTZ) (Bardet-Biedl syndrome 15 protein) (WD repeat-containing and planar cell polarity effector protein) (O95876)
Organism: Homo sapiens (Human)
Function: Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q32NR9}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q32NR9}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q32NR9}.
Interaction partners:
- Protein inturned
- Protein fuzzy homolog
- Ciliogenesis and planar polarity effector 2
- Tectonic-like complex member MKS1
- Chaperonin-containing T-complex member BBS12
- BBSome complex assembly protein BBS10
- Tetratricopeptide repeat protein 8
- Protein PTHB1
- Coiled-coil domain-containing protein 28B
- Astrotactin-2
Sequence:
MRREFCWDAYSKAAGSRASSPLPRQDRDSFCHQMSFCLTELHLWSLKNTLHIADRDIGIYQYYDKKDPPATEHGNLEKKQKLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSRCVLSKWKNKYVCQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGKLISDTISDALLTDSFIILSFLAQNKLCFIQFTKKMESSDVNKRLEKLSALDYKIFYYEIPGPINKTTERHLAINCVHDRVVCWWPLVNDDAWPWAPISSEKDRANLLLLGYAQGRLEVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLILGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQWIAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKLGVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLRQKLTPEREAQLETSLGTFYAPTRPLLDSTILEYRDQISKYARRFFHHLLRYQRFEKAFLLAVDVGARDLFMDIHYLALDKGELALAEVARKRASDIDAESITSGVELLGPLDRGDMLNEAFIGLSLAPQGEDSFPDNLPPSCPTHRHILQQRILNGSSNRQIIDRRNELEKDICSGFLMTNTCNAEDGELREDGREQEIRDGGSLKMIHFGLV
Protein: Small ribosomal subunit protein mS25 (28S ribosomal protein S25, mitochondrial) (MRP-S25) (S25mt) (P82669)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:24799711}.
Interaction partners:
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS2m
- Small ribosomal subunit protein mS27
- Small ribosomal subunit protein mS22
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein mS35
Sequence:
MPMKGRFPIRRTLQYLSQGDVVFKDSVKVMTVNYNTHGELGEGARKFVFFNIPQIQYKNPWVQIMLFKNMTPTPFLRFYLDSGEQVLVDVETKSNKEIMEHVKKILGKNEETLRRERQEREQLSHPAHFGPRKYCLRECICEVEGQVPCPAVVPLPRELTGKFQAALRAGAQD
Protein: Cullin, putative (Q38AL5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- TATA-binding protein interacting
- Ubiquitin, putative
- Ubiquitin-conjugating enzyme E2, putative
- Polyubiquitin, putative
- Ubiquitin-conjugating enzyme E2, putative
- S-phase kinase-associated protein, putative
- SKP1 component dimerisation domain-containing protein
- RING-type domain-containing protein
- RING-type domain-containing protein
- PCI domain-containing protein
Sequence:
MLDAALLLHDVSTEEKWCVISDAVNAIFKKSLSKYSFQQVHHSVFQMCQTQRSGTLFDLLHHALSKEVTIIREQLLTSTDSALLQDLETQWEDFSAALRRISDALFYLDKNYTNNQKTISQMGESLFYAGVLKNEVISNTFVSSVRQSLEFGFASQKSLKCLTSKLRELYRDTIFEPLVERPLLEVLTAKYKGEMELKLDSLDVDGYLTWALTTVGQVQSDVSKLVGDSMDQAVRQHMRGLLIKENTQKLLYSCSGGGSTMVRKMNSASLGRLADALVTVGETDALLEMLISTTKAVGCELLSEVENEDPVAAVGKVLTLRNNLQQLVEKLPGALRGDKPPIVRALAEIVNECPDFSTKLAYYYDVKARSRGTHDSMDQVAADTFSLYRLLRSKESFEQTFKLLLAARLINCKPNDSLVHEIIFVEHLRSECGDSVANHLDVMIKDGRMRTEINRGFLSSLSPDVQLPLSFDVTVITAGVWPIYPGFEINLPECMQQCVSLFQAYYIPHHNGRVLSFHTGCGTICFTLNHKEVYELAAPTSFVNTILCFQSCGGIDEPLTVKDICNKTKMIETDVLPQLEALVNTGLISNVPSGGLSRFIFNKHFAHHRTKLRIGNVGGNRTVKASAEVRVTQVASETTHAESIQAVLMQIVKRNKTLSHGEMFTQVAEALKGSRITPVMAHIKQNLEILINKGLISRGSRPDIYVYEA
Protein: Esterase, putative (Q586T2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSHILLLGDSLTEWGFECGWASRLSNVYVRRADVINRGLCGYNTRWILSILKNDESRHHLLPAYAPRPLFITLLLGSNDCATGGQAVPLHEFKSNLRAIIDLVRKHASPVGGIFLMTPPPINVEKWHKRLQREFGADPSTCGRSLERVLSYRDAVLQVGCVEKKAHNDVHVVDLYERFLGKDAESPNVAKGPWCDYLSDGLHFSETGGALVFDALMSAIESSPHSAQIIPGNVATQLPDFMTLMK
Protein: Anaphase-promoting complex subunit 1 (APC1) (Q54NC6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 8
- Anaphase-promoting complex subunit 6
- Anaphase-promoting complex subunit 2
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 7
- Probable inactive serine/threonine-protein kinase bub1
- Anaphase-promoting complex subunit 3
Sequence:
MVSIINLGKVKPFGLSYIINSNNNNNNNDDDDYNNEIRESESSIPYEYYFCQNPLKSCFNEEQKILLQSENDETDEKGMILVNNSFFEEAQLFWYQNTVVWSSPFTVKKKFTLPLLLSSMIYPKINNAIWSHFPFLKDLSKQQQEQQQQQHHQQSEYTTSSINNDIDDYYKYLCVLHNQGLNIYNSIGNSYQIVLPCKVINIWSSKFGLLLERDSSLDSTLLAGRDRSEIPSIFSILNPLEELKPVLTFSKSNNNNNNNNEALQQEFFSDTNQTIVFSSTDYPILITYSNIENVHIIYQVSHVKPSSNAENDNTNNNNNNNNTNTNISNNQTINNENGTTTTIINNSSIVNTSKPIFNFNNVSVNDQSFDYSNINISSSSPPFSSRNNNNNNNISNNNNTNNNTNNNNTNNSTSMMQQSIQQQQQQQQQQENSSFKFLNEDKSYFFDDESEFIIKSEIIFEEVLKDSTRLKSNTKSKSIFITLDNNQKPLLCIEINSTLFCYNLFIDQKIKSTQSSSSNKNNNNNNDRNEGIEEKLKLEFSFSISSVQSSSPIFIESFYNNNEYTIPKGINQPFIPLPTHILVLNDHLLSVYWGPFKILDLPIDNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKRKPLYIKDSTFNRVTIVYSDKEEIRFKITLGKSYLVSSCLGALSSFIPMNLLASIYQDFNDFHKFRINNLLNSNSNNNNNNNNSEEENDKEWISFQILLISLLEKSLLKRPTDADTNKKIKENNHIKKEENEDDWEFLLNSNYHKNYEKGLSFLSNLNISDSSKVYPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCNIFIESINDFNFKTSLNSFIESIDDIIIALHHQYEEFKILTFNINYIYKLSKFLIQLSLHLELFNYVDYYFRDFGDLIDFINQFKIKSKTSIDISSLKLQSLLNDDIFSIYKFVYNSFNENNSETQQQQQFNKEKFERNKLTKYHFKWIYKMKSLYSIQSKINDNNSNNKNNIKYISEKLIMKMVELDIKLEDLNSISFGLSLPLRESIKYCRSNPPIDWPLKAYSLIEREELIYKFNIDDVNNVKDGLKINSLLISGGKNKLLSNSTMNHGYNSLSTSITNTLSTASSSSNEMNSNSNITSINGQSNGLPMNSTTNQMNSHQINNNGGGGGGGDDHHHHHSNSTSFDLSKFYHGQDEFYKRITYLRFDTDQRIQEVYRLLSFSNRIQINHTQENGVSDHDYLSQLQSKLLLSVQRSISLPIACGMFTIRSIKPLPTETINIPPIILNGFVGGTKTNISLDPTMVQDNMMVWPEFHNGVAAGLKVSADQTEITNTWIIYNRPKQFNPSYSGLLMALGLQKRLSSLAFTKLFEYLASGHQLTSVGLLLGISCTKMGTMDMSIAKVLSVHIQSLHPPLSIDLDVPSYVQIAALMGIGLLYCQTSNRRMTEVLLMEIGRKPINDKPLDRDSYSLTAGMALGLVNLGKGANEGSLTDLHVEDRLRSFIGISKEDSFDHMSTFFNQSYSTPSISSNRNNNDLFNNGSNNNSSSNGGGGGGGGNNNGNNSNNGNNGSSQFKKSNTILESSKPNIDLTAPGAIIALSLIYLKTNNLKISNYLSIPDTTFGLNYIRPDLVLLRILGRNLILWDSIKPQFQWIIDSVPLVVRKNVTIDRNSEKVFQEHSNNNNNNNKSRSSSSLNDFESFILIFCNVIAGAAFSIGLKYAGSLNENAFSLLMDLIQLFRKRQVYLNKCLLKKKKIEPTFDKVMRVTTETCLNVVALSLSLVMAGSGNLETLKILRMLRSRIGNEITYGNHMAINMAIGFLFLGGGQYTLSTSNIAIASLVCSLYPRFPCSSTDNDYHLQAFRHLYFLAIDPRCLITRDVDTLAPCHVPIELTILNNDTMKLETKQLVTPCLIPELSSIRSISIKSPRYWNIFINRGFVDGGVDININNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNILKNHPTIFLKRKIGHLPYTEDPEGFRSLSKSFPKSESISLYSSSKGFQKNKEEFLKSFISDPNLLAFAKHFCTNQSNEFEHFNTTILYECLTQDTPEVIPLLLLLNDIANNFEKYSNSNTTIVLENLRIIFKFYSKWNNGYYLNNNNNKNNNNDGWLIHSTFLDSISTKIDEHFEKHFLNEQSNKKLLSNYLLTGELPNSLSTSIKRKFASFISYYNLPNNKQFQSFKSLLNNNNNNNSNAIYQLWSSLGNQINFNSINKIIELSTLSFDEDS
Protein: Palustrin-3b (P84262)
Organism: Lithobates palustris (Pickerel frog) (Rana palustris)
Function: Antimicrobial activity against Gram-negative bacterium E.coli.
Subcellular location: Secreted {ECO:0000269|PubMed:11087945}.
Interaction partners:
Sequence:
GIFPKIIGKGIKTGIVNGIKSLVKGVGMKVFKAGLSNIGNTGCNEDEC
Protein: Break repair meiotic recombinase recruitment factor 1 (Q6DIA7)
Organism: Mus musculus (Mouse)
Function: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility.
Subcellular location: Chromosome {ECO:0000269|PubMed:32345962, ECO:0000269|PubMed:32460033, ECO:0000269|PubMed:32463460, ECO:0000269|PubMed:32845237}. Note=During meiosis, recruited to chromosomes and localizes on recombination sites in a double-strand break-dependent manner. First appears on the chromosome axis at leptotene. Along with the progression of meiotic recombination, released from the axis to form bridge-like structures linking homolog axes before they are synapsed. Finally, located between synapsed homolog axes and on the synaptonemal complex (SC). {ECO:0000269|PubMed:32345962, ECO:0000269|PubMed:32460033, ECO:0000269|PubMed:32463460, ECO:0000269|PubMed:32845237}.
Interaction partners:
- Heat shock factor 2-binding protein
Sequence:
MNKKKQRNSGVGLHPSKPSKNPRLRDSQSSMMVHSHYSRESEDSSEPAPSVELGGEEPLHEAFSCPVEDTGAASDLAGSPKELVPLPPSQNSVGKFVPQFAKPRKTVTRKAKAWEEDLEGCTTSQETRPELGALKAASQPQRESLRFPPHDIRPEVQTQPDGTLSKERTISLDNRSLGNNGFEMATVQDSSSPLSDAAAEGREADSRDPQERDAQGGEAGAQHSGEPQEGEDILYTSALAPASEPTWSVAQDLSVPTYTLSSTAAAPSSTSPADASLMDTVITEVSLDPSVLQQSAPQVAKLLGSLDEQIPDGGCIGTLLSSTPLAEETTAGREEARWEERCHGDTLASFTETEPEKQEPVTEAGDSGHIAQEMDPVVKTKDSGSDEQSPGDIGMLPLPAQSMNQMLVELRGLTCDQDLEGLSTPHTSSQLEHTCAASDPPQSTKDCHSSPGIPVHLAAPCPRDQAAWQESSAMELDFLPDSQIQDALDATNMEQGFPSGSMPDLGWPVPSSQSIGGSPKAVTKPQSRSHVETWAQETYRMQDATDTVRGLVVELSGLNRLIMSTHRDLEAFKRRKTKSLPYLTKGLGSLPRGDQSWRDL
Protein: Erythrocyte membrane protein band 4.1 like 3 (A0A0A0MRA8)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRREVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSMSAAEVGTGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTPISAIRHEGKTDSERTDTAADGETTATESDQEEDAELKAQELEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEGAKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED