wanglab/gogpt-training-data huggingface dataset:
Protein: Ino eighty subunit 5 (P40060)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ino eighty subunit 1
- Ino eighty subunit 3
- Non-histone protein 10
- Ino eighty subunit 4
- Chromatin-remodeling complex subunit IES6
- RuvB-like protein 1
- Transcription initiation factor TFIID subunit 14
- RuvB-like protein 2
- Actin-like protein ARP8
- Actin-related protein 4
Sequence:
MPSKDPESVIDKEIRKISARNDELIKQDGTLKREYTTLLRKVSSVITVLNSIDDADTGSAETELPRLISQATVEKVPELKWYNDQISLITEKLEDDEDIEVPEELMDAYTLYKETPLLYNDTHTP
Protein: Epidermal growth factor receptor pathway substrate clone 15, isoform D (MIP26607p) (E3CTP7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNVDFARVCGKHIGVYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSLSQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAVPPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSMRATVAGVDLQPQEVKPTYSNPELEMISKEIEELARERRVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVTKIRDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTKEVQLPKDDPFEENNSGAANQATNGFGSDPFSGQPVNKPAISTGFDDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTGGFGSGGGGGFADFDDFDNK
Protein: Gustatory receptor (Q57U78)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein transport protein Sec61 gamma subunit, putative
Sequence:
MVGSASRSCGTDMVNDAEMYGGSENQPQNSSNAVTDSTPKLSRWPDGTTFEGPLVDGVPEGHGTCVYKSGCVCVGSFSRGCVEGPAEALLPCGAFFVGNFCRSAAHGHGVLLQNGRLVRGEWRDGVLVRRTLENVNDARDVQFYTRVIAKLCHRVEELNGTIERDSSSVFQQTSNSGLCIREPIVLLRDEQQQERDAVQTRRWARVATQSPPYMRNEPHGAGMPPLAREPDISPRFDRGSFSSLNTHRRQPTALDLNQLTSFARSVLASGASQQAIFASAAPAANEFFSPTRYLQCFFIMLFPFISLPQFSFSPIRRVMLKMEREFVVSGAFLFRSFNVPIYTLTFSTIATCCLIATVVIVSLKVELGPVTEGKVTLEELFIPCILWVAQSALYAAYNSYVRVAHALERLDRRLTPQLYACAAGIVNTKAKVCIFTWDDEGRRVVTNVHYRYRWLGESLFVGILFSLAGPLTRVSYKQPMFGYTKYEVSALVLISASVLVFAAMVTFNALKLTDMQRQIKEQMRALTHLAYVEGKSVMHPSEHLLQRFNLDEPFNVSDIFNGVSGWYVIRSVVVYAASCSNHAARGLAMSVFFMLVNSCFLVTALDMICMLSFHYNDLGKRFSCMHAYGVVTCSVWGILLLRYLYKCVETVCESERHLYLLDVASLYHRTRYNNAEGCADIITTCRKMVKAYEQLPCVFLFPITPFIITIVVILYIVALLIATIHVYFAAVARFADTGGR
Protein: Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST class-kappa) (Q09652)
Organism: Caenorhabditis elegans
Interaction partners:
- Glutathione s-transferase kappa 2
- Glutathione transferase omega-1
- Probable glutathione transferase omega-2
- alcohol dehydrogenase
- Probable phytanoyl-CoA dioxygenase
- Glutathione peroxidase 1
- Glutathione S-transferase omega
- Glutathione S-transferase P 10
- Glutathione S-transferase omega
- Probable glutathione S-transferase 6
Sequence:
MPKLPRIDFYFDVISPYSYIAFEVFQKLETQWKGVTIRYIPFFLGAVMKESGNRPPAMLPARSIMMMTDLKRTAKFWDIPLTPPPLFMEWIKKYRTTGAMKVLLVLQEQDKELMLRAAREMWVRLWSRSEKIFEDQDFVEVLKAVGVKNPEQIVEKSKDEKYIKILMENTNKGVDLMAYGAPWINVHTEDGSEHSFFGSDRFHLIADLLQQPQPLPDRLFGQKSKL
Protein: Protein patched homolog 1 (PTC) (PTC1) (Q13635)
Organism: Homo sapiens (Human)
Function: Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q61115}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Desert hedgehog protein
- Indian hedgehog protein
- Sonic hedgehog protein
- Protein smoothened
- Growth arrest-specific protein 1
- Cell adhesion molecule-related/down-regulated by oncogenes
- Brother of CDO
- Transcriptional activator GLI3
- Suppressor of fused homolog
- Zinc finger protein GLI1
Sequence:
MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Protein: Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Q86VQ3)
Organism: Homo sapiens (Human)
Function: Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11399755}. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.
Interaction partners:
Sequence:
MDVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAVIAELK
Protein: Bromodomain-containing protein 2 (A8CYR1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Ral guanine nucleotide dissociation stimulator-like 2.
- Histone H4
- Histone H4
- Protein cereblon
- Proteasome subunit beta
- Retinoic acid receptor RXR-beta-A
- Cyclin-dependent kinase 9
Sequence:
METALSPPFDSSLGGCDGMQGLTMMEQTISGPGKRIRKPSLLYEGFEGPALPHIAQSGPPQPAVRDPSRQGRMTNQLQFLQKALVKTLWRHHFAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQKVAQMPEVEEEIPAPVPRGKQSKPKKGQKLFSGGITTAHQVPAISSLSQLAYSPPTPDTPDSVLSTPPQTLITKNFPPPPLHSTPALLGLPPTQPTAKKKGVKRKADTTTPTTTVMPLTLGVGGMGMGMGMGMSMGMGMGMGLGGDSPLTLSNMGMDSKQSLSLSLGMSLEDKVPARRGGSGRPIKPPRKDLPDSQNQHQPVRRGKLSQQLRYCSTILKELLSKKHTAYAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDHDVVAMARRLQDVFEFRFAKMPDEPLESLPPASLGGGLGGDSSSSSSSSSSSSESDVSSESESESSPSSDSEEERAHRLAQLQEQVCTQLRAVHEQLAALSSTPIIKPKKKKEKKDKKKKKKPEKHKRSRSVIEDEVVMRPAKIPKLPKTPKSRSNSKAATSTQSKKSSNKKSNKSKSSKKAQPTFFPPPLSHSGLTPHYDSEEEEETSPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDTNPEEIEIDFETLKPSTLRELERYVMMCLRKKPRKPFVAIKGSAGKSREELALEKKRELERRLQDVSGQLNSVKKPQKTKAEKPSAVEPHAVASRLSASSSSSDSSSSSSSSSSSDTSESDSD
Protein: Uncharacterized protein C1D4.02c (Q10149)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus membrane {ECO:0000255|PROSITE-ProRule:PRU01212}.
Interaction partners:
- Intracellular protein transport protein uso1
- GRIP domain-containing protein C119.12
- GTP-binding protein ypt1
- Integral membrane protein sed5
- Serine/threonine-protein kinase plo1
- Protein transport protein sec24
- Protein CASP
- Uncharacterized protein C589.03c
- Protein sly1
- Protein transport protein sec13
Sequence:
MFGGLKNFIKEKSEALAGIHRESDESCGFRVLKVENDSKAYNARIESYYDFITAVNGILLNGDPSMFMALLRDSSPEVTLEVFSLKGQITRKVNIKINSDEKIGMVLQWASIAPAVDAIWHILNVIDDSPVARASLVPYEDYIVGTPEGMMTGEKALSDLIESHLNRPLRLYIYNHYRDSTRQVTIVPNRHWGGNGAIGCGVGHGVLHRLPAPLSGPPPQPGDIVFSNPMLGGPDHKVSQPSETENFLPTPEPPKIASANAGSSNEISIPHYQRHKKSHKGAIQDSSIQSYLDEEEKLSRELDHKTKDASSTNDSQTTPLPPPPPVAVNSTNDESAPQNEELVKN
Protein: PID domain-containing protein (Q8I4G9)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MKKTQLGRSFSKSFKQKKARASNASSDPFRFQNNGISYKGKLIGEQDVDKARGDAMCAEAMRTAKSIIKAAGAHKTRITLQINIDGIKVLDEKSGAVLHNFPVSRISFIARDSSDARAFGLVYGEPGGKYKFYGIKTAQAADQAVLAIRDMFQVVFEMKKKQIEQVKQQQIQDGGAEISSKKEGGVAVADLLDLESELQQIERGVQQLSTVPTNCDAFGASPFGDPFVDSFNSTATSNGTANMSGTQVPFGGLQLPQVQQMQMPMVQIPQQSHQNWPTSGAGSFDAWGQQQQQQQMHHAHSTPAFGTNGFSDTNPFASAFNTQAPPPPLPTVAPTQYRDPFSVHSSAIPNSNIDWTGTGTTKENMAPSTNIQQQQSSLHHASTFANFGDNKAETWSEKKVTSLEEAFTKLVDMDALVGGQGIKETKKNPFEHILNPPKASLNSMSTTCSAAQMAATQQHTTSSHADPFGDDFFR
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Q965V9)
Organism: Caenorhabditis elegans
Interaction partners:
- Ubiquitin-like protein NEDD8
- Ubiquitin-ribosomal protein eL40 fusion protein
- Polyubiquitin-A
- Ubiquitin-like domain-containing protein
Sequence:
MTTKGKGGWQALESNPETINPFLKKIGITGLECVDVYSFDDEMLQFVPTPQLALILCFPSAEAREFLSKQYEEVEKNGEKPEGVFFMNQSEEIGNACGTFALFHSLANLENRVNLGKGKFAKWYEKAKLVNEDERSDLLSGDTDLAEAHEETAEEGETEQSDHVDYHFITYVNKNGQLYEIDSCAPFPRPLGATTDSTMIKDASTAIKELMNNVKNLSFSAMALVGK
Protein: E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (A0A0U1RR39)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT
Protein: Phenoloxidase-activating enzyme (EC 3.4.21.-) (Prophenoloxidase-activating enzyme) [Cleaved into: Phenoloxidase-activating enzyme light chain; Phenoloxidase-activating enzyme heavy chain] (Q9XXV0)
Organism: Bombyx mori (Silk moth)
Function: Endopeptidase with selective post-Arg cleavage site. Activates prophenoloxidase. Has a probable role in the melanization process as part of the innate immune response (Probable).
Interaction partners:
Sequence:
MFLIWTFIVAVLAIQTKSVVAQSCRTPNGLNGNCVSVYECQALLAILNNQRRTQQDEKFLRDSQCGTKNSVPAVCCPCNAADGQQGNCVNINSCPYVLQLLKNPNEANLNYVRGSVCQGSEQQSICCVTAPQSTAVTTTPRPKRVHACQSEMTATPPNPEGKCCGRDIAVGDKIVGGAPASIDSYPWLVVIEYVRLERTMLLCGGALISGKYVLTAGHCVKGAILDVGTPKTVRLGEYNTTNPGRDCVSVSAGGTDCTDPLVKIGIEKTIPHPDYQPYHFLRKHDIGLIRLQSIAPFTDFIRPICLPSTDYTVNPPSKFALTVAGWGRYLQFDNGTVRSSKIKLHVTLPFVQRDVCEANQKPLRNGQRITLWKGQMCAGGEAGKDSCKGDSGGPLMYEHSKKYEAVGIVSFGPEKCGQIDIPGVYTNVYEYLPWIQNTIEP
Protein: Oxysterol binding protein like 5 (E9PPQ2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSVVIMADSLKIRGTL
Protein: Sporozoite and liver stage tryptophan-rich protein, putative (Q8IBD1)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MNLEQFKNINKDLATNLFSQLSFLKNENKFLSQGKSLIKFLIGIAIFLVVLIFIKSSHPALKEKKKKVLEFFENLVLNKKKKENITAAIASKELADAETTDTSDSEDEDHIINKKVKRRKRNIINNPDEKVHNVKEKNSKSKNEEDKTDESYNETSLLSSDEEGEVNLEDWKKNEWIKWMDETEEEWQLLKLWLEGEKNKWLEGKNKEYDIWLNHMNSKWTNYNKDIDEEYDSNVFKDSYKWNEKQWEQWMKTEGKEFMLQDFKRWLEDSEGYLKSWLIKQWIQWKNMKILECLMNEWRREEDEKWSNLEDTDQIRVLNHKDRKEWLRWKERVTREKLEWKHWVEMKENMNIYNKWKKWIKWKKNKLANFNEWSKNFIEKWIREKQWNNWINERKKYTSQRKSLEQQFGDNMDKMNKLKKKKILKFFPLFNYKSDLESIMEEDENEYNSFDENEEENDEKTGDVNVGKTEALNVAKTEGLNVGKTEDLNVAKTEDLNVAKTADLNAEKTTDLNSEKTADLNSDKTTDLNPEKTTNFNTYKATDLNANKTADLNSDKTTDLNSDKTTNFNTYRTTDLNSDKTTNFNTYKTDLYAEKTTDVNLGKTTNHNVAKTTDQKVVKHSLDHEVRQMIDQKVAQIMNHDLESTAEQKAEKKGGKAKAKTKVRTVDDDGNEINV
Protein: LD17368p (Osiris 6, isoform A) (Osiris 6, isoform B) (Q9XZ15)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- FI03362p
- Osiris 15
- Osiris 20
- Osiris 8
- LD24139p
- IP06949p
- Osiris 19, isoform A
- Dusky-like, isoform A
- Osiris 18
- Osiris 21
Sequence:
MNTPVISVVPKEFSLRNHQSTNPATSMKFFVATACILLLAAGISADPVKAAEEQPGAFAQCLESDSISCLQLTLFRKAKSVFDNPQIELFGGVSLVKSNEGRQGKSLDNSLAVEAAPTVEARTAEMGNYFMDNAKSFFAERSLNFNFANAARSVARAIPDDIKADLRELVVESRTRKKKLLKKFLPILLGVGAKIAVLGVGSIFGLLFLAKKALVVSVIAFFLALAAGASSGLGRIGGSGGGGGLLGGLGGLFGGKNAGGSSAASTGGWSSGGGASSAGWSSGGSSGWDTHGAYSSPVAQTIAYQGYKQARR
Protein: Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part] (Q9JM99)
Organism: Mus musculus (Mouse)
Function: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q92954}.
Interaction partners:
- Aggrecan core protein
- CD44 antigen
- Toll-like receptor 2
- Toll-like receptor 4
Sequence:
MGWKILPVCLSLLLPVVLIQQVSSQDLSSCAGRCGEGYSRDATCNCDYNCQHYMECCPDFKRVCSPELSCKGRCFESFARGRECDCDSQCKQYGKCCADYDSFCEEVHNSTSPSSKTAPTPAGASDTIKSTTKRSPKSPTTRTIKVVESEELTEEHSDSENQESSSSSSSSSSTIRKIKSSKNSANRELQKNPNVKDNKKNTPKKKPNPEPPAVDEAGSGLDNGEFKLTPPPPDPPTTPHSKVATSPKTTAAKPVTPKPSLAPNSETSKEASLASNKETTVETKETTATNKQSSASKKKTTSVKETRSAEKTSDKDVEPTSTTPKNSAPTTTKKPVTTTKESKFLPLPQEPEPTTAKEPPPTTKKPEPTTRKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPPPTTKKPEPTTPKEPGPTTPKEPEPTTTKEPEPTTTKEPESTTRKEPEPTTPKEPEPTTPKEPEPTTLKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKKPEPTTPKEPVPTTPKEPEPTTPKEPEPTTPKEPEPTTRKEPEPTTPKEPEPTTPKEPEPTTPKKPEPTTTSPKTTTLKATTLAPKVTAPAEEIQNKPEETTPASEDSDDSKTTLKPQKPTKAPKPTKKPTKAPKKPTSTKKPKTPKTRKPKTTPSPLKTTSATPELNTTPLEVMLPTTTIPKQTPNPETAEVNPDHEDADGGEGEKPLIPGPPVLFPTAIPGTDLLAGRLNQGININPMLSDETNLCNGKPVDGLTTLRNGTLVAFRGHYFWMLNPFRPPSPPRRITEVWGIPSPIDTVFTRCNCEGKTFFFKDSQYWRFTNDVVDPGYPKQIVKGFGGLTGKIVAALSIAKYKDRPESVYFFKRGGNIQQYTYKQEPMKKCTGRRPAINYSVYGEAAQVRRRRFERAVGPFQTHTFRIHYSVPMRVSYQDKGFLHNEVKVSTMWRGFPNVVTSAITLPNIRKPDGYDYYAFSKDQYYNIDVPTRTARAITTRSGQTLSKIWYNCP
Protein: Eisosome protein SEG1 (Stability of eisosomes guaranteed protein 1) (Q04279)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Important for the biogenesis of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations. Required for efficient incorporation of the eisosome component PIL1 into eisosomes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11914276, ECO:0000269|PubMed:19269952, ECO:0000269|PubMed:22869600}; Peripheral membrane protein {ECO:0000269|PubMed:11914276, ECO:0000269|PubMed:19269952, ECO:0000269|PubMed:22869600}; Cytoplasmic side {ECO:0000269|PubMed:11914276, ECO:0000269|PubMed:19269952, ECO:0000269|PubMed:22869600}. Note=Localizes to eisosomes.
Interaction partners:
- Eisosome protein 1
- Sphingolipid long chain base-responsive protein PIL1
- Sphingolipid long chain base-responsive protein LSP1
- Uncharacterized protein YGR130C
- Meiotic sister-chromatid recombination protein 3
- Non-classical export protein 2
- Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1
Sequence:
MFRRRTTAPEMEQADPTAVAAAASIGKLLMKKGNQSDNEQRPTYRSASMTNLRKPSAPKRMSSISSISSESRRSDGKGRPGKINSLTQRSSMGKGDSLNSPLTKEPQHKTRSHNRTSSLPNQRGQQSRNSSGLQRQKSKTHQRISYDEAQRTFKDFGGPQARGILTGQHRTENPSGSIPLRTTRKYIPGPNGLVAIEVPVEKPSNANTSKLLRRSNSAHSALNARNGSLLRKKVSQESLHSQPKKTSSLGNTSSTQAKKGQKAVQERNLAKKHPINSNVPLIETQVREETDQELKLDNSNSSESETVVNSENNLEKPSSLNIEKDDLSKLIHENIELESFIEEKGKEKPLNSDQEDVFISEKTVKGDVQWPKNNRQASTLEKTFNYDNEEKREGNKPVAEHPLPEAEVDDKSVEQLNNISSSGSYSAQGSVENSKPENGNKNLENDTTSSPTQDLDEKSRSIEEKDTLEGTESSKKVEKPDNCCEKISGANTSSKKGNVGDTKDEFFDTVEESDQKTSKSNSSKNTDHSNQTEPTPSLAQYLRTSNTYLSRKNQSKQAEQEKFHKPEAPMVPVTKVVTPIKSALKKSSGSSNHDSSMYSDNSPANGAYLSLTTAENTRLNAQMTMSDSVSRRASLKRSSIKRPQSVGQFRSIRSNSPSPPEKINNKRHSAIPLGTPEKGKPKRNSVMASLSKNSQQIQEPASVYESNGPNKPKNQINKNIKRGSQIAQNNKPSTKDMNSILYPKEPPPRKSSFEKTRSNESHLGFKKLSLRNGNFEEALSESYNGQASQNSTNVNRTDTAQEFFKYLGHSSRFADSDSEDESQFFNQGPSKYNTETEGNKTSGNKNSNGGNGAFSLFKSKSKQKENNVVSPGVSSPNHTTTDPAITSKKVDKKFSGLSLRAASEAEPAKNSNPSMTNRLRFSSNPENGESRLPQAQEVSVTKEKKGSFGKKLKKIFGRKK
Protein: Nematode cuticle collagen N-terminal domain-containing protein (O17209)
Organism: Caenorhabditis elegans
Interaction partners:
- Cuticle collagen dpy-5
- Cuticle collagen sqt-1
- Protein qua-1
- COLlagen
- Nematode cuticle collagen N-terminal domain-containing protein
- Cuticle collagen lon-3
Sequence:
MMETSEHKELRRVAFFAIVVSTVAVIAAIVILPMLYSYVAGFQSHLIIEADFCKTRSRDMWAQIHDIDGPHLFHRQKRQYSSPNPPAAGGYGAPVTNSEPAPTCCSCQQGPAGPPGPPGDDGNGGQDGVRGNDGTDGKEGSLLESAIVNEPCIICPPGPPGPQGMAGAKGPQGPKGGNGDNGPDGKAGANGMQGPPGMMGPPGRQGVSGPKGAPGRINQINGPAGPAGHKGVRGPPGPRGEAGLDGGNSEGPQGPQGDAGRPGPVGEQGPQGPEGPQGPPGEPGGCEHCPIPRTPPGY
Protein: Fli-1 proto-oncogene, ETS transcription factor a (Friend leukemia integration 1 transcription factor isoform X4) (A0A2R8QGN6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004019}.
Interaction partners:
Sequence:
MTMFQTVPDTSSYVKEALSVVSEDQSLFEPPYAAAAPLPKTDMTASGTQDYGQTHKINPIPPQQEWINQPVRVNVKREYDHINGSRESPVDCSVGKCNKMVGGTEASQMNYTGYMDEKCAPPPNMTTNERRVIVPADPSLWSPDHVRQWLDWAIKEYGLQEIDTAMFHSTDGKELCKMSKDDFLRLTSVYNTEVLLSHLNYLRESSSSISYNTPSHADQSPRLAAKDDASYDAVRRTGWSNNMHSGKGSPTVVSQSVSKNPDQPRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANAGCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESTMYKYPSELPYVPSYHAHQQKVNFVSPHPPSMPVTSSNFFGPTTPYWSSPPGGIYPNPSVPRHANSHVPSHLGSYY
Protein: RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (P09560)
Organism: Xenopus laevis (African clawed frog)
Function: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}.
Interaction partners:
Sequence:
MEHIQGAWKTLSNGFGFKESVFEGSSCMSPTIVHQFGYQRRASDDGKLSDTSKTSSTMRVYLPNKQRTVVNVRSGMSLHDCLMKSLKVRGLQPECCAVFRLIQDPKGKLRLDWNTDAMSLVGAELQVDFLDHVPLTTHNFVRKTFLKLAFCDICQKFLLNAFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNPNNIEGGSHTLPSLTMRRIGESVRIPVSSQQRYSTPHPFSFSTPSPVSECSLSQRQRSTSTPNVHMVSTTMAVDSRVIEDALRSHSESGSPNNLSPTGWSNAKAPAPTHREKAASSTGQEKNKIRARGQRDSSYYWEIIASEVMLSSRIGSGSFGTVYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYYHLHVLDTKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQLTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHIRDRDQIIFLVGRGGVVPDLSKLYKNCPKAMKRLVADSIKKLRDERPLFPQILSSIELLQHSLPKINRSALEPSLHRAAHTEDISSCALTSTRLPVF
Protein: RNA polymerase-associated protein LEO1 (Q38DC5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- PWWP domain-containing protein
- Cell division control protein 73 C-terminal domain-containing protein
Sequence:
MYRHGLESEEQRHEDLLLLPTQSDTQTTEERTTANPTTQGATDEGGSGAADGEGAATYLTPRAVSVDSDLTLEDLFGPFFYVDKSLVVVDPALLGSRSLLRRFFGDTICETDVDITSDNEEALRKEVELARKEACVNYVYELFGEEGAAIIGTQEPKPFDCLVSSVPDKQNVGLYEEMWLTDMPKIAPNRQTLHMEPRPYVSSNPSAPLRSTERSLYTTQNVIRWSIGCRDKLFVSNARIVRWSDGSTTLRVGSDSFPLQLSRDNAITMLASPSAISKGDLTLPAMVSVINPSKHFVAECNSAASIEKAVNEENQRIRSVSAQHNLAYSVPTLPSVDWNNLAASGTPEGEFLARSYNLRKKMMEQRKNRGEPMTLTEQLQMESELFEKLQSLSAKELLEQQQEQERQAALRSLTRQNQTAHRRRFERTVELEGGEYREGHNSMGGGNTGLNGGDFDNNDEDEEIEDDYETMLENVRRKRQREDDEADAKHARNIRLYEQARAGQYGSLIDSMQDLLSQLPDGSIVRESVDETVEFLRAGSFSPAVVIKEVPLMLEGVASECPDVDIGKVREELRKLHERK
Protein: Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.8.27) (Protein Mob) (Sphingomyelin synthase 1) (Transmembrane protein 23) (Q8VCQ6)
Organism: Mus musculus (Mouse)
Function: Major sphingomyelin synthase at the Golgi apparatus (By similarity). Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes (By similarity). Does not use free phosphorylcholine or CDP-choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (By similarity). Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q86VZ5}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ceramide synthase 3
- Sphingomyelin phosphodiesterase
- Ceramide kinase
- Sphingomyelin phosphodiesterase 4
- Ceramide synthase 2
- Neutral ceramidase
- Ceramide glucosyltransferase
- Sphingomyelin phosphodiesterase 2
- Acid ceramidase
- Ceramide synthase 4
Sequence:
MLSARTMKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLYRVSSDNGQRLLDMIETLKMEHHMEAHKNGHANGHLSIGVDIPNPDGSFSIKTKPNGMPNGFRKEMIKIPMPEPERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLFQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQVRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT