wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2) (Q4KLY4)
Organism: Rattus norvegicus (Rat)
Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers. Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes. Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9CQJ4}. Cytoplasm {ECO:0000250|UniProtKB:Q9CQJ4}. Chromosome {ECO:0000250|UniProtKB:Q9CQJ4}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells. Co-localizes with SAMD7 in nuclear polycomb bodies. {ECO:0000250|UniProtKB:Q9CQJ4}.
Interaction partners:
- RING1 and YY1 binding protein
- BMI1 proto-oncogene, polycomb ring finger.
- E3 ubiquitin-protein ligase RING1
- Polycomb group ring finger 2
- Polycomb group ring finger 5.
- Chromobox protein homolog 7
- Polyhomeotic homolog 2
- Polycomb group RING finger protein 1
- Polycomb group RING finger protein 6
- YY1 associated factor 2
Sequence:
MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAVAIDPVMDGASEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQYTIYIATASGQFTVSICQ
Protein: Large ribosomal subunit protein uL15x (60S ribosomal protein L27a-3) (P49637)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein uL18z
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein eL32z
- Small ribosomal subunit protein eS21z
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL3z
- Large ribosomal subunit protein eL42z/eL42y
- Large ribosomal subunit protein uL23z
Sequence:
MTTRFKKNRKKRGHVSAGHGRIGKHRKHPGGRGNAGGMHHHRILFDKYHPGYFGKVGMRYFHKLRNKFFCPIVNLDKLWSLVPEDVKAKSTKDNVPLIDVTQHGFFKVLGKGHLPENKPFVVKAKLISKTAEKKIKEAGGAVVLTA
Protein: Probable BOI-related E3 ubiquitin-protein ligase 3 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BRG3) (Q9LDD1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable E3 ubiquitin-protein ligase. Has no effect on the stability of the DELLA proteins.
Interaction partners:
- Selenium-binding protein 1
- HTH-type transcriptional regulator
- Probable disease resistance protein At1g12290
- Probable N-acetyltransferase HLS1
Sequence:
MAVEAHHLNPLFSSNREMIHPVEASGVVYNTQMRYGTVPTFNPTVECQTSLFNPIYNISPVDRLVHQSMKPTIQSVDSSLTFNSDNNVDFLRPVSSRKRSREESVVLNPSAYMQIQKNPTDPLMFLGQDLSSNVQQHHFDIDRLISNHVERMRMEIEEKRKTQGRRIVEAVEQGLMKTLRAKDDEINHIGKLNLFLEEKVKSLCVENQIWRDVAQSNEATVNALRSNLQQVLAAVERNRWEEPPTVADDAQSCCGSNDEGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGKGEASVLLLPCRHMCLCSVCGSSLNTCPICKSPKTASLHVNLSS
Protein: Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (TNNI3-interacting kinase) (Q5GIG6)
Organism: Mus musculus (Mouse)
Function: May play a role in cardiac physiology.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Expressed at lower levels in the cytoplasm. {ECO:0000250}.
Interaction partners:
- Troponin I, cardiac muscle
- Fucose-1-phosphate guanylyltransferase
- Leucine-rich repeat and IQ domain-containing protein 3
Sequence:
MGNYKSRPTQTCSDEWKKKVSESYAIIIERLEDDLQIKENEFQELRHIFGSDEAFSEVSLNYRTERGLSLLHLCCACGGNKSHIRALMLKGLRPSRLTRNGFPALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQSDLEVQPHVINIYGDTPLHLACYNGNFEVAKEIVHVTGTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQNAVNINHRGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAELPSRFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRKLEECLCNVELMSPASSNSSGSLSPSSSSDCLLSRGGPGRSHVAALRSRFELEYALNARSYTGWPQSVGTHTNPGLSLEEMNRGAQYSAVDKYGYVSDPMSPMHLHSRRNSGSFEDGN
Protein: Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Q55D87)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Kinase
- Kinase
- Multiple inositol polyphosphate phosphatase 1
- 3'
- Inositol-pentakisphosphate 2-kinase
- 2,3-bisphosphoglycerate 3-phosphatase
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- Inositol-3-phosphate synthase
Sequence:
MGRNNTLPNDFTVGYYLSDSKINKLKWNLFVDMCKEKYNINVVPIDMNKDINSINTRPYHVIIDKLTDELGDLDNPSNKQKVDYIQSLIDKFPSIVEVDPLESQKPVLSRDTLTKLLDKLNDVSPELNIKNPKFVLVPEDYNNNDYNQLLKDANIKFPVVCKTIKACGSKESHYMGIVFNEKDIHQFKQPMLIQEFINHNAIIYKVFAIGDFIQVVHRKSIRNMNENENELIKFDSQKPFPTSLLPTDGQELKIEMPSKSTLSVISKDIQKNLDISLFGFDVIVDCETKKLAVVDINYFPTFSGVDDFYTLLIEHVINVYKRKSSV
Protein: Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) (Q6AYS4)
Organism: Rattus norvegicus (Rat)
Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Tissue alpha-L-fucosidase
- Beta-galactosidase
- Alpha-galactosidase
Sequence:
MRLGLLMFLPLLLLATRYRAVTALSYDPTWESLDRRPLPAWFDQAKFGIFIHWGVFSVPSFGSEWFWWYWQKERRPKFVDFMDNNYPPGFKYEDFGVLFTAKYFNANQWADLLQASGAKYVVLTSKHHEGFTLWGSAHSWNWNAVDEGPKRDIVKELEVAVRNRTDLHFGLYYSLFEWFHPLFLEDQSSAFQKQRFPVAKTLPELYELVTKYQPEVLWSDGDGGAPDHYWNSTDFLAWLYNESPVRDTVVTNDRWGAGSICKHGGYYTCSDRYNPGHLLPHKWENCMTIDKFSWGYRREAEIGDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGIIPVIFEERLRQMGTWLKVNGEAIYETHTWRSQNDTVTPDVWYTSKPEKKLVYAIFLKWPISGKLFLGQPIGSLGETEVELLGHGRPLTWTSSKPSGIVVELPRLSVHQMPCKWGWTLALTNVT
Protein: Innexin (Q9N3R5)
Organism: Caenorhabditis elegans
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU010713}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU010713}.
Interaction partners:
- Innexin-14
- Uncharacterized protein
Sequence:
MGFSAIDKLIRPFLQLHEWDNGAERIVHTTTIQILICFGFLVSSNMMFGQPITCLMLPETPDSSANYFHDFCFYQDKLRIPPLHNAVKRSTRQGTMNINNIMPQEVAVTYYQWTPFIIFLQVAMCLVPALMWKFFGLHYFYGHDFAAIVRSLASKKKDDKMDSSNSNYEVDARETLRWLEHKKRERFGMHTTMMIYVAMKWMTFASLLFQFNLMAKIYASGELLWGVHISYELLNGAYKNVYTGVFPQIVGCNPHRAQLGGVVNEFIMRCILPQNFVNSKVFLFLYWWYILAMLVSIYSAVQFTAMLFLPKYQRYATKSLLPTEEFFNEHAEKPTKGSLEFFVDYMGNDGYLLLQCASVPLSVVRIRFFLNSLYTIVVEKKKEYEDQKPMVPRKQKTPIDHIQFDGPDRSGTKGPYKNGKAMIMSDGDSYTKQLLSHSSPSCSPASSQRYSAAPGKNLEDYE
Protein: TRPL translocation defect protein 14 (Q7K556)
Organism: Drosophila melanogaster (Fruit fly)
Function: GTP-binding protein which is required for the light-dependent internalization of the TRPL ion channel from the rhabdomere on the apical surface of photoreceptor cells to the cell body and for the recycling of TRPL back to the rhabdomere in the dark. Binds to 3-phosphoinositide (PtdIns(3)P) and phosphatic acid and so may interact with membranes, particularly the early endosome membrane where PtdIns(3)P is predominantly localized. Plays a role in preventing photoreceptor degeneration.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:26509977}.
Interaction partners:
- Kelch domain-containing protein 10 homolog
Sequence:
MATLLSNGQQSVMASTSNGQEQQRHQDEPEQQQQVEIRKSSSPKPGAMPSLKLNRMGSVSPKDKRVYKIVLTGGPCGGKTTGQSRLCTFFENLGWKVFRVPETATVLLSGGVKFSDLTEKEAYKFQENLIRTMVQIENTYFELGNSSNRNCLIICDRGVMDASAYISKDKWEKMMAGNNWNPVEMRDNRYNQILHLVSAANGAEDFYSTEDHACRSEGVDLARELDYKSAAAWVGHPYFDVIDNSTNFETKMNRMIESVCQKLGIDIGDRLQATSRKLKYLVALLPPDSEFPPFQDFDVVHHYLQSAGPKVQARLRKRGQKNHWSYIHTQRRPNVHGQARIEVKTQLTHRDYMNLLAQRDDAHFTIYKKRRCFLINNQYFQLDIYKEPGHPRCKGLVLLETYSSLTGDALKNCMPKFLNIVKEVTGDPDYSMFNLSLKEDWSTTKKFCRSATHGKQEEQSPVPAKQYHPYDENSD
Protein: Insulin-like growth factor I (Q6V293)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Secreted {ECO:0000256|RuleBase:RU000406}.
Interaction partners:
- Insulin-like growth factor-binding protein 3
- Insulin-like growth factor binding protein 3
- Tyrosine-protein kinase receptor
- Tyrosine-protein kinase receptor
- Tyrosine-protein kinase receptor
- Insulin
- Insulin
- Vascular endothelial growth factor Ab isoform X1
- Hepatocyte growth factor
- Vascular endothelial growth factor A
Sequence:
MSRGHLGDVLKWTMRCVSRGRALARLLLLLCALALTPVAARAGPETLCGAELVDTLQFVCGDRGFYFSKPTGYGPNSRRLHNRGIVDECCFQSCELKRLEMYCAPVKSGKAPRSVREQRHTDTPKTPKKPISGHSHTSCKEVHQKNSSRGNTGGRNYRM
Protein: DNA repair protein XRCC4 (Q682V0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. May bind to DNA. The LIG4-XRCC4 complex is probably responsible for the NHEJ ligation step, and XRCC4 may enhance the joining activity of LIG4 (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- DNA ligase 4
- ATP-dependent DNA helicase 2 subunit KU70
- Transcription factor bHLH140
- ATP-dependent DNA helicase 2 subunit KU80
- DNA ligase 1
- DNA polymerase lambda
- DNA ligase
- DNA-repair protein XRCC1
- DNA ligase 6
- DNA excision repair protein ERCC-1
Sequence:
MIGVDSKSSSTTFIETMVESEKTKHTCLRLEISGADPIFVKGTWHNSRFDISVTDGSSSWICNATEEEVAERAAQWDQPVSEYLKLAEQYLGFQQPNSVYSFSDALEGSKRLSWTFEKEGTKLEWRWKCKPSDDSKKITVGILDFLMEANIRLSEEVVNKTRSFEKMRSEAERCLAQGEKLCDEKTEFESATYAKFLSVLNAKKAKLRALRDKEDSVRVVEEEESTDKAESFESGRSDDEKSEEEASKKATSSKARGGKRAARS
Protein: NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial (EC 1.14.13.253) (3-demethoxyubiquinone 3-hydroxylase (NADH)) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7) (P97478)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity). Involved in lifespan determination in a ubiquinone-independent manner. Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:11387338, ECO:0000269|PubMed:11511092}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:11387338}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:11387338}.
Interaction partners:
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Ubiquinone biosynthesis protein COQ9
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- All trans-polyprenyl-diphosphate synthase PDSS1
- Atypical kinase COQ8A, mitochondrial
- Atypical kinase COQ8B, mitochondrial
- All trans-polyprenyl-diphosphate synthase PDSS2
Sequence:
MSAAGAIAAASVGRLRTGVRRPFSEYGRGLIIRCHSSGMTLDNINRAAVDRIIRVDHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKNHLKKFNELMIAFRVRPTVLMPLWNVAGFALGAGTALLGKEGAMACTVAVEESIANHYNNQIRMLMEEDPEKYEELLQVIKQFRDEELEHHDTGLDHDAELAPAYALLKRIIQAGCSAAIYLSERF
Protein: FYVE-type domain-containing protein (Q389L9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGTIFSNVRTHEEVPPEVKDKVEPITYVPAPESARPRDGRFCSSCEEPFCFYFTPSTNCDWCGRQFCTHCCPERYLLRGNPCCPDCTKRAYTIKRSQLLKEHLSMMSSTRSAEVHVAN
Protein: Candida glabrata strain CBS138 chromosome M complete sequence (Q6FIW5)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- low-specificity L-threonine aldolase
- Candida glabrata strain CBS138 chromosome J complete sequence
- Glycine cleavage system P protein
Sequence:
MSQGRKAAERLQGKIAFITGASAGIGKATAIEYLDASNGSVKLVLGARRMEKLEELKKELLAQYPDAKIHIGKLDVTDFENVKQFLADLPEEFKDIDILINNAGKALGSDKVGDIDPEDIAGMVNTNVLALINLTQLLLPLFKKKNSGDIVNLGSIAGRDAYPTGAIYCATKHAVRAFTQSLRKELINTDIRVIEIAPGMVETEFSVVRYKGDKSKADDVYRGTTPLYADDIADLIVYSTSRKPNMVVADVLVFPTHQASASHIYRGD
Protein: Protein argonaute-2 (G5EES3)
Organism: Caenorhabditis elegans
Interaction partners:
- ALG-1 INteracting protein
- Endoribonuclease dcr-1
- Protein lin-41
- ALG-1
- Protein argonaute-1
- DRBM domain-containing protein
- Piwi-like protein ergo-1
- Hyaluronan/mRNA-binding protein domain-containing protein
- Staphylococcal nuclease domain-containing protein 1
- RING-type E3 ubiquitin transferase
Sequence:
MAAELNNTNTNESSNVASNDPMSGGPQYLPGVMNSTIQQQPQSATSSFLPSGPISSTSTSSQVVPTSGATQQPPFPSAQAAASTALQNDLEEIFNSPPTQPQTFSDVPQRQAGSLAPGVPIGNTSVSIGEPANTLGGGLPGGAPGQLPGGNQSGIQFQCPRRPNHGVEGRSILLRANHFAVRIPGGTIQHYQVDVTPDKCPRRVNREIISCLISAFSKYFTNIRPVYDGKRNMYTREPLPIGRERMDFDVTLPGDSAVERQFSVSLKWVGQVSLSTLEDAMEGRVRQVPFEAVQAMDVILRHLPSLKYTPVGRSFFSPPVPNASGVMAGSCPPQASGAVAGGAHSAGQYHAESKLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYRSMPVIEFIAEVLELPVQALAERRALSDAQRVKFTKEIRGLKIEITHCGQMRRKYRVCNVTRRPAQTQTFPLQLETGQTIECTVAKYFYDKYRIQLKYPHLPCLQVGQEQKHTYLPPEVCNIVPGQRCIKKLTDVQTSTMIKATARSAPEREREISNLVRKAEFSADPFAHEFGITINPAMTEVKGRVLSAPKLLYGGRTRATALPNQGVWDMRGKQFHTGIDVRVWAIACFAQQQHVKENDLRMFTNQLQRISNDAGMPIVGNPCFCKYAVGVEQVEPMFKYLKQNYSGIQLVVVVLPGKTPVYAEVKRVGDTVLGIATQCVQAKNAIRTTPQTLSNLCLKMNVKLGGVNSILLPNVRPRIFNEPVIFFGCDITHPPAGDSRKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIISDLTYMVRELLVQFYRNTRFKPARIVVYRDGVSEGQFFNVLQYELRAIREACMMLERGYQPGITFIAVQKRHHTRLFAVDKKDQVGKAYNIPPGTTVDVGITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNNLTADELQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDREHDSGEGSQPSGTSEDTTLSNMARAVQVHPDANNVMYFA
Protein: GTPase (Q72FZ5)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
Sequence:
MKDAAIVTGRPTPPESPGATDLHGRDRHQEGPRNVVIMGAAGRDFHNFNMLYRHAPEVRVLAFTAAQIPDIAGRNYPAVLAGPAYPEGIPVIAEEELSTYCLGVRLDEVVFAYSDVSHEEVMHKASRALACGADFTLVSPSRTMLVAHRPVVAVCAVRTGCGKSPVTRHVADTLRHEGLRVVVVRHPMPYGDLAAQAVQRFASVQDMDDARCTIEEREEYEHLVEAGLVVYAGVDYERILAQAEAEADVIIWDGGNNDTPFFRPDVHITLCDALRPGHEVGYHPGETNLRMAHIVVVNKADDARPEQVARVCVNAAAANPGALLLGGASRVTVDTPDAIAGKRVLVVEDGPTLTHGGMPFGAASVAARVFGAAQTVDPWPHAAPSLRATREAYPHLDRALPAMGYSPEQVRDLADTISATPCDLVLSGTPVDLARLIVMTRPHLRVRYTFEDAPLPCTTGAPTETWGNTPDTPETSGRPDRHGIAEGTGLRTTLAQAVLDRIMPLVRKGID
Protein: Transcription factor E2FC (E2F transcription factor-2) (AtE2F2) (Q9FV70)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11891240}. Note=Interaction with either DPA or DPB are unable to induce a nuclear localization.
Interaction partners:
- Transcription factor-like protein DPA
- Retinoblastoma-related protein 1
- Transcription factor-like protein DPB
- Protein ALWAYS EARLY 2
- Protein ALWAYS EARLY 1
- Protein ALWAYS EARLY 3
- Transcription factor MYB3R-3
- Histone-binding protein MSI1
- Transcription factor E2FB
- Cyclin-dependent kinase A-1
Sequence:
MAATSNSGEDPTLSYHHRSPFRFELLQSISSSDPRYSSLTPSSTNRPFSVSQSLPNSQLSPLISPHWDDSYSQITQKVQKSRKNHRIQLGSIANMSGGESIDIAKVIVKQESSPQNVKRVYNKSKGGTKLLKAGKRMANGEVQNGGLNGASINCRYDSSLGLLTKKFVKLIQEAEDGTLDLNYCAVVLEVQKRRIYDITNVLEGIGLIEKTTKNHIRWKGADNLGQKDLGDQISRLKSEVESMQSEESRLDDLIRERQEALRSLEEDDYCRRYMFMTEEDITSLPRFQNQTLLAIKAPTASYIEVPDPDEMSFPQQYRMVIRSRMGPIDVYLLSKYKGDSAETSDKLGNESDQKAPVGVDTPSLKIVTSDTDLKADYWFESDAEVSLTDLWSNFNS
Protein: OhrR (Q9HZZ4)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Organic hydroperoxide resistance protein
- OxyR
- Glutathione peroxidase
- Redox-sensitive transcriptional activator SoxR
- Alkyl hydroperoxide reductase subunit F
Sequence:
MSRLPTTPCEQLKLDNQLCFALYSTSLQMTKVYKPLLQALGLTYPQYIAMLVLWERDGLTVGEISARMLTDPGSLTPLLKRLEGEGLITRTRSSEDERVVLLRLTDKGRALQRQAESIPACILESTGLDLPQLVALKDELLALRGNLQAPD
Protein: E1A binding protein p400 (A0A0A0MR80)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQLMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSYIQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQISLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQSPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGVLLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPEMAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQNDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPKVSAAFSSQQQPFQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGVPLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPAGVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALHVPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPARSSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQVHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKRKKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEEETIEEEEANEGVVDHQTELSNLAKEGRLLLPY
Protein: DNA mismatch repair protein MSH4 (AtMSH4) (MutS protein homolog 4) (F4JP48)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in meiotic recombination in association with MSH5. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossovers formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:15489296, ECO:0000269|PubMed:18318687, ECO:0000269|PubMed:19153602, ECO:0000269|PubMed:21217641}. Note=In pollen mother cells during meiosis, localizes to unsynapsed axes during leptotene and zygotene, but is not present on synapsed regions of zygotene nuclei.
Interaction partners:
- DNA mismatch repair protein MLH1
- DNA mismatch repair protein MLH3
- ATP-dependent DNA helicase homolog MER3
- DNA mismatch repair protein PMS1
- Crossover junction endonuclease MUS81
- DNA mismatch repair protein MSH5
- Exonuclease 1
- Meiotic recombination protein DMC1 homolog
- Meiotic recombination protein SPO11-1
- ATP-dependent DNA helicase Q-like 4A
Sequence:
MEDDGGERSSFVAGLIENRAKEVGMAAFDLRSASLHLSQYIETSSSYQNTKTLLRFYDPSVIIVPPNKLAADGMVGVSELVDRCYSTVRKVVFARGCFDDTKGAVLIQNLAAEEPLALGLDTYYKQHYLSLAAAAATIKWIEAEKGVIVTNHSLTVTFNGSFDHMNIDATSVENLELIDPFHNALLGTSNKKRSLFQMFKTTKTAGGTRLLRANLLQPLKDIETINTRLDCLDELMSNEQLFFGLSQVLRKFPKETDRVLCHFCFKPKKVTEAVIGFENTRKSQNMISSIILLKTALDALPILAKVLKDAKCFLLANVYKSVCENDRYASIRKKIGEVIDDDVLHARVPFVARTQQCFALKAGIDGFLDIARRTFCDTSEAIHNLASKYREEFNLPNLKLPFNNRQGFFFRIPQKEVQGKLPNKFTQVVKHGKNIHCSSLELASLNVRNKSAAGECFIRTETCLEALMDAIREDISALTLLAEVLCLLDMIVNSFAHTISTKPVDRYSRPELTDSGPLAIDAGRHPILESIHNDFVSNSIFMSEATNMLVVMGPNMSGKSTYLQQVCLVVILAQIGCYVPARFATIRVVDRIFTRMGTMDNLESNSSTFMTEMRETAFIMQNVTNRSLIVMDELGRATSSSDGLAMAWSCCEYLLSLKAYTVFATHMDSLAELATIYPNVKVLHFYVDIRDNRLDFKFQLRDGTLHVPHYGLLLAEVAGLPSTVIDTARIITKRITDKENKRIELNCGKHHEIHRIYRVAQRLICLKYSRQTEDSIRQALQNLNESFTEERL
Protein: Heat shock 70 kDa protein cognate 4 (Heat shock 70 kDa protein 88E) (P11147)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm, perinuclear region. Nucleus. Note=Localized to a meshwork of cytoplasmic fibers around the nucleus. Translocates to the nucleus after thermal stress.
Interaction partners:
- DnaJ homolog subfamily C member 5 homolog
- Heat shock protein 83
- DnaJ-like-2, isoform A
- RE23625p
- Stress-induced-phosphoprotein 1
- Starvin, isoform E
- GrpE protein homolog, mitochondrial
- DnaJ protein homolog 1
- Hsc70Cb, isoform G
- Cell division cycle 5, isoform A
Sequence:
MSKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEEVD
Protein: AP-3 complex subunit beta (F4IWW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000256|ARBA:ARBA00004145}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004145}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004145}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Interaction partners:
Sequence:
MFNKFGSTSETLSKASAGLLRIGTDAHLYDDPEDVNIAPLLDSKFESEKCEALKRLLALIAQGFDVSNFFPQVVKNVASQSSEVKKLVYLYLLQYAEKRPNEALLSINYFQKDLGDPNPLVRAWALRTMAGIRLHVIAPLALAAVSKCARDPAVYVRRCAANALPKLHDLRLEEHASAIEELVGILLNDHSPGVVGAAAAAFTSICPNNFKLIGKNYKKLCQILPDVEEWGQILLIGTLLRYVVARHGLVRESLMLSIHGTNSNGFCEKDGLGRDLTLDKEDGGKSDSFDVNLVSLVSKCYIQGPDEYLSRSSCTDTVSSAFDTKETTSIAHNEDVKILLQCTSPLLWSNNSAVVLAAAGVQWIMAPLEDVKKIVKPLLFLLRSSSASKYVVLCNILVFAKAVPSLFAPHFENFFICSSDAYQVKAYKLEMLSLIATTSSIASILREFEDYIKDPDRRFAADTVAAIGLCAKRLMTIPTTCLDGLLALVRQESFAGDFESADGEAGVLVQAVMSIQTMIERDPLRHEKVLIQLFRSLDSIKVAAARATIIWMVGVYCSLGHIIPRMLTTITKYLAWSFKSEASETKLQILNTIAKVLISAEAGDFHMLKRIVVYVFELGEYDLSYDIRDRTRFLKKLLSCKLASHEPAEDSVASQENIAAHVVEHVFGRKLKSVSPITLHNRFYLPGSLSQIVLHAAPGYEPLPKPCSFVYEEQDQLSDLDKQREAAADLDGSEESSETGDENGSSDYDSESSNGSDFSSEGDERTVSNDANDPAAPLIQISETSVSADQEELRSRRALDLWLDDQPSTSNQTPSALNSNQSSYAKISIGDVGSRVKPKSYSLVDPGNGSGLKVDYAFLSEVSNVSPLHVCVEVLFENSSAEPILEVNLEDEESMKVADSSEQTLVGKANASYNNIPTLIPMEEISCLEPHQSTKRLIQVRFHHHLLPMRLTLHYNEKKVPVKLRPDLGYLVKPFSMSIEEFLATESRLPGMFEYSRRCTFDDHVKDSRTENGKDKFLSICESITLKVLSNSNLHLVSVDLPVANSLEDATGLRLRFSSKILSSEIPLLITITVEGKCTEVLNLTVKINCEETVFGLNLLNRIANFMVEPSSSAT