wanglab/gogpt-training-data huggingface dataset:
Protein: Spindle pole body component (C8VMB1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000256|ARBA:ARBA00004267, ECO:0000256|RuleBase:RU363050}.
Interaction partners:
- Spindle pole body component
- Gamma-tubulin complex protein 3
- Spindle pole body component
- Spindle pole body component
- Tubulin gamma chain
- Mitotic-spindle organizing protein 1
- DASH complex subunit ASK1
- Nucleoside diphosphate kinase
Sequence:
MLHEILLSLSGQQSSLFSFQTEEDAVSEESFPLLSPPEKALLASLARLSRLHARLQAHTALICSTHASVICRAVSTAIRSHHLGAFQKKILEVEKAILVEDSGYVGGYGIVPLATVVGEFAPWTRRLEWLWEVVRFILPTEKKKHTQSCTGAGLIDHLRRESHTGYIDIEEIVLDLIGAAETAWMRQLSTWLLYGNLPILGKGDFFIQEADTKENEGPVSTVQFTIHTQLIPQFVSSHTAASILFIGKTLNLMRAKRSPTGHTPDGLLTSPVTLQSEHISHLAGLKSPISASELSNTVDSIRTSLSQSTLSKLLPLPKILEILSLLHNFLLLQRGEFATALVLHADARLRERQRGPESSSARHVSNSVDGLAIKEGDVATTLTKTWAELYSLQNEEDPVDDELDLARELVRLSLKPRDHGQNPGFSGAAAADPVAETSNTPFDDLLFPTSTSLSVHVRPPLDLFLSAADISIYSKMHSYLLGIRRAQIRLGDLWKHSPLRRSHPSPWGPPRSNSRFGQSRLQMGRQRENARTSKMRAIWATGSASLFVLSEIGSYFQGEVINESWQHFRDWIEAGVSDSPPSTSRPGTATSSKARRIGLATNEQSEDEPGAAPRRHDPEALTAAHRQYLYSLVQSLFLNDTPFTKALRDLLARIDHFIALVIRLEIIQRNMDLESDEGVVDALVDYASEERGVWNALRAARADTERGINEVIARLQDIDDSRTQEGRMMFQPTANTTGSWMVGHMNGCSFRPRKAAGVDRLLMKLDFGTARN
Protein: Iroquois homeobox protein 3b (Q6NY58)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MSLPQLGYKYIRPLYSTERRGGAEISVTGSGSLSSALSGVYGAPFASTAQGYSAFLPYSSDLSVLNQLSSQYEFKDSPGLQHAGFPHAAFYPYGHQYQFGDPSRPKNATRESTSTLKAWLSEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWVPKTRTDEDGNVYTSDNEDAEKRDEDEEIDLENIDTEDIEDKQDCDYQDDDKSTPKGSDSEEYDDARAEKRIIEDEEQIKKSPAEEQEPSNNISPALKPKIWSLAETATTPDSPKKTWIQRNCDAQTVRNPLHVQNWTKMALSAHQMAFTSHYLGLKHQSITNIHVKHAEQRTHSL
Protein: Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver) (P43024)
Organism: Mus musculus (Mouse)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P12074}; Single-pass membrane protein {ECO:0000250|UniProtKB:P12074}.
Interaction partners:
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 8A, mitochondrial
- Cytochrome c oxidase subunit 6B1
- Cytochrome b-c1 complex subunit 9
- Cytochrome c oxidase subunit 7A2, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome c oxidase subunit 6C
Sequence:
MASAVLSASRVSRPLGRALPGLRRPMSSGAHGEEGSARMWKALTYFVALPGVGVSMLNVFLKSRHEEHERPPFVAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE
Protein: Alpha-2B adrenergic receptor (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR) (P19328)
Organism: Rattus norvegicus (Rat)
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P18089}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18089}. Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. {ECO:0000250|UniProtKB:P18089}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit alpha-11
- Alpha-2A adrenergic receptor
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Sequence:
MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
Protein: Calnexin homolog (P27825)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
- Mannosyl-oligosaccharide glucosidase
- Killer toxin-resistance protein 5
- Protein disulfide-isomerase
- Glucosidase 2 subunit alpha
- ER degradation-enhancing alpha-mannosidase-like protein 1
- Protein transport protein SEC61
- Protein RER1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3
- Mitochondrial import receptor subunit TOM20
Sequence:
MKFSAYLWWLFLNLALVKGTSLLSNVTLAEDSFWEHFQAYTNTKHLNQEWITSEAVNNEGSKIYGAQWRLSQGRLQGSAWDKGIAVRTGNAAAMIGHLLETPINVSETDTLVVQYEIKLDNSLTCGGAFIKLMSGFMNVEALKHYAPDTEGVELVFGPDYCAPEINGVQFAINKVDKITHESKLRYLQEMPLSKLTDTSQSHLYTLIIDESAQSFQILIDGKTVMVREHIEDKKKVNFEPPITPPLMIPDVSVAKPHDWDDRIRIPDPEAVKLSDRDERDPLMIPHPDGTEPPEWNSSIPEYILDPNAQKPSWWKELEHGEWIPPMIKNPLCTAERGCGQQIPGLINNAKYKGPGELNEIINPNYMGEWHPPEIENPLYYEEQHPLRIENVISGVILEFWSGSPNMLISNIYVGKNVTEAQIIGNKTWLMRDRAFRGSDGPTERKFMNSRLGNLQTTFHNERESPNPFDRIIDRILEQPLKFVLTAAVVLLTTSVLCCVVFT
Protein: LP05054p (Q9VQX6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MSKAGEDQPAAEGAVIAGNGNAELAQNEGQNEQQQPPPNQPTRMESFFAMTKSLILRALIIYFVSSFFRRPAPDAASQGKSVANAGPKITAWNYFENGTDFDLHVWLSENPDVVNFQQKANLLWLQKDLTYGDWTSGVNGDGIYTHSLKLKTSQHLMNNGSVYLHAFVTRTGMSPDPKAPNYATKMGHQQHQLNKFKKLRVNRNYNLLASEKEKLEHELKHANLKDTIVSHWHPNLTVNLVVDQTNWAEGSVPPPLDDYVKFVDGGKTYLPILFVNDYWNLQREYQPINETTPELELHLTFQPLGMFKWQLYAAKQMKNKWAGNMLGELMAASQPEESDEDQDSLKETLLDTNIYLLGITVAVSILHSVFELLAFKNDIQFWNNRKSLEGLSVRSVFFGVFQSLIILLYVLDNETNFMIRISCFVGLGIEVWKIHKVVDINYDHDQKILGVLPRISFQDKGSYSESSTKDYDKLAFKYLGWACFPLLVAYFVYSLIYNEHKGWYSFVLNMLYGYLLTFGFILMTPQLFINYKLKSVAHMPWRMMTYKFLNTFIDDIFAFVIKMPTMYRLGCFRDDIIFFVFLYQRWQYRVDLKRVNEFGFSGEMEQQHAAQKLEGKTANGAIEGPQAAPAIKKTAAQKKQD
Protein: Solute carrier family 35 member F3 (Thiamine transporter SLC35F3) (Q8IY50)
Organism: Homo sapiens (Human)
Function: May be a thiamine transporter.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MKKHSARVAPLSACNSPVLTLTKVEGEERPRDSPGPAEAQAPAGVEAGGRASRRCWTCSRAQLKKIFWGVAVVLCVCSSWAGSTQLAKLTFRKFDAPFTLTWFATNWNFLFFPLYYVGHVCKSTEKQSVKQRYRECCRFFGDNGLTLKVFFTKAAPFGVLWTLTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHSVIGIALVVASASMSALYKVLFKLLLGSAKFGEAALFLSILGVFNILFITCIPIILYFTKVEYWSSFDDIPWGNLCGFSVLLLTFNIVLNFGIAVTYPTLMSLGIVLSIPVNAVIDHYTSQIVFNGVRVIAIIIIGLGFLLLLLPEEWDVWLIKLLTRLKVRKKEEPAEGAADLSSGPQSKNRRARPSFAR
Protein: DASH complex subunit DAD3 (DUO1 and DAM1-interacting protein 3) (Outer kinetochore protein DAD3) (P69850)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:14562095}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14562095}. Chromosome {ECO:0000269|PubMed:36701236}. Note=Associates with the mitotic spindle and the kinetochore (PubMed:14562095). Associates with origin of replication (ORI) sites during interphase (PubMed:36701236). {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:36701236}.
Interaction partners:
- DASH complex subunit DAM1
- DASH complex subunit DAD4
- DASH complex subunit DAD2
- DASH complex subunit SPC19
- DASH complex subunit DAD1
- DASH complex subunit ASK1
- DASH complex subunit DUO1
- DASH complex subunit SPC34
- DASH complex subunit HSK3
- Large ribosomal subunit protein uL10m
Sequence:
MEHNLSPLQQEVLDKYKQLSLDLKALDETIKELNYSQHRQQHSQQETVSPDEILQEMRDIEVKIGLVGTLLKGSVYSLILQRKQEQESLGSNSK
Protein: TPR repeat-containing protein C19B12.01 (O36033)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Periodic tryptophan protein 2 homolog
- U3 small nucleolar RNA-associated protein 21 homolog
- RNA cytidine acetyltransferase
- Uncharacterized WD repeat-containing protein C3D6.12
- Probable U3 small nucleolar RNA-associated protein 13
Sequence:
MVAIENKEVLFGGSLKSTEEYDQFFCPSIDIPKFLFKYWDSKPLGKNVSSDQFAETAIQMLEYFIQNNYTGPYLPIKPEIWLPQRLRDEATLKDAIIKSLTVEGERPYRLAPKLLFLLLSQTLFNYANSKDPLHIWYKARLDFLHQQMLKEHVSELFNQIMEGMHIVSSHVSSLDRDLQGRFTMEMGLIQSYYGRDTLALQLMKESAKVMDFHFELTGALGRRTKFQTFDTSQLVVLAKSRDRCKDTEQNKSTSTQPITFELNDDTLLEKISFKEDQKSLAPSEELDPILSSEDPNHPSKLDPLDASLLLAFCHIIKNNNPDDGLTREEMAPYAERVLVYPVNWSVYTMALLVRARLEGFKSRTVERSVLQMQALLDQLNDQLSFGKSPEGVDKPENDEGLGSFLPKPQDGENSASLKERLNYFYNLLMPSRWQLEAELAERFISVGATKSALEIFERLQMWDCVVMCHCSLNRQDLAVQVIKRELENDPYDFLLRTLLGDIENNPKHYVEAWELSCKRFAPAQRSLGKYYYKKGDLLQAMNCFNESLKINPLSYPTWFTYGCAALELQKYDAAMEAFSRCLSINPEDGESWNNLASAMLKAKDHTKEQAWHAMQQGIKYMYDNWRIWENYMLISVDVNKWSEVIRALRRIIEIKGKDEGERAVDVQCLDLVVNYVMQSCDNDASGLARMLNELLKMVVPLITNDVRLWRIVARYYLWRRHFAESLNATLKAYRILISSPNVTSDEATWNKTVEGALELVEAYANLGEMPGRMGGVVAKDWKFKSRSVLRSLIGKGKNIWENTESYQKLESELENLK
Protein: Beta-1,3-glucosyltransferase precursor (EC 2.4.1.122) (Beta-3-glucosyltransferase b) (A0A068F5P3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037847}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037847}. Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Interaction partners:
Sequence:
MSRYTAGHNVIYFCCSLLSFVPSCNALNDDSCEKPPRSGAEMYGRHIELRDVLFVIQSQRNSYHTQRAEQRRKEILHQAQTVTQSSPDVVLLHKLSHYDGNWSILPALPRLALQYCQTSLWIMFLQEETIVNLHNLLQVLSRFSPGKEWFLGRSLHDDEPTIIHHYAFSEDPYSFAYPDFMAGWAISCPLAKRTAERVNYEPPKSDFTIDLQHEIALYIWEEGRGPTLTAVNEFCSELHGSSSAKCCATAVNTYLSACGKPVLKEDVFVAVKTCQRFHRDRVPIVKQTWEKDAASLEYYSDVTDSIIPTVHLGVPNTERGHCEKTFAILRRFASGAVTQAPWLLIVDDDTLISLPRLRRLLSCYDPTEAVSVGERYGYGLSRDGYSYITGGGGMVFSRVAVQNILAGGCSCRSSDAPDDMVLGMCLTTLGLPVTHSPLFHQARPDDYVKELLARQSPISFHKHWNIKPVAVYQRWLSEPDQRPHWLTDTREEL
Protein: Muscleblind-like splicing regulator 1 (A0A8I6AQ03)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAVSVTPIRDTKWLTLEVCREFQRGTCSRPDTECKFAHPSKSCQVENGRVIACFDSLKGRCSRENCKYLHPPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPDTHNICRTSD
Protein: DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (O42410)
Organism: Gallus gallus (Chicken)
Function: Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q13422}.
Interaction partners:
- Protein cereblon
- DNA damage-binding protein 1
- Paired box 5
- IKAROS family zinc finger 3
- Interferon regulatory factor 4
- Runt-related transcription factor
Sequence:
METDEAQDMSQVSGKESPPISDVPDDADEPMPVPEDLSTTTGGQQSVKNERVLAGNIKIETQSDEENGRACEMNGEECAEDLRMLDASGDKMNGSHNGPGSKAMSGVGGIRLPNGKLKCDICGIICIGPNVLMVHNRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLQTMSISSNLYSVIKEETNQSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFVGEKCLSDLPYDATTNYEKENEIMQTHVIDQAINNAISYLGAESLRPLVQTPPVGSEVVPVISPMYQLHKPLGDNQTRSNHTAQDSAVENLLLLSKAKSVSSERDASPSNSCQDSTDTESNNEERSGLIYLTNHIGPHARNGISVKEESRQFDVLRAGTDNSQDAFKVISSNGEQVRVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS
Protein: BCL11 transcription factor A (D3ZSY3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- BCL11 transcription factor B
- B-cell CLL/lymphoma 7 protein family member A
- Actin-like protein 6B
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
- Transcription factor SOX-6
- AT-rich interaction domain 1B
- AT-rich interaction domain 1A
- Actin-like protein 6A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- BAF chromatin remodeling complex subunit BCL7B
Sequence:
MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKGVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPSLHGIPIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDEGRALPDVMQGMVLSSMQHFSEAFHQVLGEKHKRSHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLTFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCPSHTPVRRSTPRAQDVWQFSDGSSRALKF
Protein: 4-hydroxy-4-methyl-2-oxoglutarate aldolase (HMG aldolase) (EC 4.1.3.17) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112) (Regulator of ribonuclease activity homolog) (RraA-like protein) (P40011)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
Interaction partners:
- Glutathione transferase 3
- Glutathione-specific gamma-glutamylcyclotransferase
- Uncharacterized mitochondrial membrane protein FMP10
Sequence:
MSDLQKLQRFSTCDISDGLLNVYNIPTGGYFPNLTAISPPQNSSIVGTAYTVLFAPIDDPRPAVNYIDSVPPNSILVLALEPHLQSQFHPFIKITQAMYGGLMSTRAQYLKSNGTVVFGRIRDVDEHRTLNHPVFAYGVGSCAPKAVVKAVGTNVQLKILTSDGVTQTICPGDYIAGDNNGIVRIPVQETDISKLVTYIEKSIEVDLLVSEDIKNGIPAKQAQNDRRSVLKKYI
Protein: Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein] (Q90VU7)
Organism: Human immunodeficiency virus type 1 (HIV-1)
Subcellular location: Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04078}; Lipid-anchor {ECO:0000256|HAMAP-Rule:MF_04078}; Cytoplasmic side {ECO:0000256|HAMAP-Rule:MF_04078}. Virion {ECO:0000256|HAMAP-Rule:MF_04078}. Secreted {ECO:0000256|HAMAP-Rule:MF_04078}. Host Golgi apparatus membrane {ECO:0000256|HAMAP-Rule:MF_04078}. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved. {ECO:0000256|HAMAP-Rule:MF_04078}.
Interaction partners:
Sequence:
MGGKWSKSSVIGWPAVRERMRRAEPAADGVGAVSRDLEKHGAITSSNTAANNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
Protein: Regulator of chromosome condensation 1 isoform 2 (A0A0S2Z404)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS
Protein: Uncharacterized protein, isoform I (Q8IMB8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MDSTLNIENVNDPTSIASDLSAENTKADLVSLNEPNVNDQTSSASDLTAENTKADHDSLNKPKDFNNQILNIISDIDINIKAQEKITQLKEQELKLIQKQNDLANEIHKQQILAKQLSAQNQLKQNECQSGELDLHSQYQNERGGPTSTLYQEKNIASKESANVSKTVDLRKIFTPATDAAEILPKNRKLYASSAFYSPTLHPTVEDQVELARRISHSLSDISNQTSKGQSMYVNRKKRSDKWVHEGGSQDFQQYQQRPVLSPNILPAYSDAGKHRVQLNIHQNQLIEKYSKPGLQVVQSPWKAALQTGSASSAFLEDTKSFSPPALTPIPSSQAGSKDWTDANEPMPHGSSRRNTNAVASSPRSVIVPSNPQRDLAYTPCVAQGWGGRSVELPKGLYVPKEISLSSYAAPSQQCEIHSKHFERPYEDTFPRTFPRNNYSANNNFPGNDGIGEFPLSKPTGLTTGTLHQQPYSPTSYKKTVPGLEKVENFARYEQPDRKRLTSGSPQYLNALQNSQVRNASPIPFGTSLNEQTSWPPRSVLLQGGSPSPLPNHVQTFNKCAKGWGSIPVKQQSYSSQYNLPGNLPYSDF
Protein: MIF4G domain-containing protein (Q7JMF0)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSNAVSRGPGRGKPNQDHNAVPMQDSSQQFVMPFVNTSGPVNSNYQRMPMNQSAYPQYGQQQYNQPQTNHYYPPQAPQHQQQYGGYQRPDYGHQPQMYNQQYQGYQAPQQYHPEMPYQPAQPAQQQMTHTAPQEPKRQRKALEIVDPTTKKAIEVTPHLAPAAPAPAAPAAPIAPEEEKKKQNITLEFLNQVKNELHHEDRRHDNPPAVPAAVPAAVQAAVLPNFSVPPPALGQTPPAASIAPQVVPSVPKTPEAPAKADYEVKQAETLVTPVSSPHASDTTTTTPASGTAESASTVADVRVTPTLTKEESKEETDDDKFEENDERESTPDVADSSTEKTPEELEIEKAQKEAEEIEKKKLREEALEKRIEELILAGSAVISDGTFGRDFMVTIREIEKVFSRTPCPLSPAQLADFGLDIKTMRVSDNKKPNFTPNWANKGGNRQQPYRGRTTTDGTGRGGQQQRDRMHNKRPPVVRPSIERVQRVTLPSSKDAWKPDRQKTAEAVASEEAAVIEVCKKVRSLMNKVTPTSQRPLTEEFISYNVSSNDAQLAQVVEIVFDKAVEEPKFCALYAEMCKAQANHELSQTGGKSAFRNKVLTRTQMTFQDKKDIDADKLAIIEKEEDPVKKELMLAEEKQKFRRRKFGVMTFMGYLYRNQLLSTKIVQTCTFELFNSIKDQDIKKEDVDEESIHCGLQLIETVGVMLDKSKDSTTVFLDQWFQKLEAAKPYCSNKIRFMIMNLMELRKDKWIPRKSTESGPKKIDEIHKDIRQEKIENEKARDQYDRDRDRRHGGVRPNSNSLRKSVPVSRNSLDRNRGMQHPEQKRAAAAANTKLASSSVQPKNISLSSMDNNTLGKSKKEWHSGASGGGNTSSESAVPVKSAWGRRDSNDQRKKSTVDEKQAALAAAKEISAMSISSRRSTSQNSNTDKTDDELTEEEKAVRAKIMNTVKSDLLEMSSGELSQKELVDSITDYVGKEKYGSPSLTVVYEMIIRAVIEKGLKDDDRKKLAIALRMSLVSKTEKQAFIEGATRFCKFANDVELQQDYPKLWTVTGEVLVNTSHAPHDEIGEVESFSLADMKPIFSAAKGEGNKKFDLLVQVLKQLIELELEVTGAAEGISWEFSDMKLKTEMEEGLSAEMEAVTFKNGKTLSSYLTGN
Protein: Centrosomal protein 112 (A0A8I6GHW6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MRPLRDIGPSIPKENMALQDELETRSNQVRSAEKKLQHKELEAQEQMMYIRQEYETKFKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQSRR
Protein: Adherens junction protein p120 (Q7PLI0)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
Interaction partners:
- DE-cadherin
- Catenin alpha
- Canoe, isoform E
- Polychaetoid, isoform O
- Armadillo segment polarity protein
- Vinculin
- Protein pangolin, isoform J
- Tyrosine-protein kinase
- E3 ubiquitin-protein ligase Hakai
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Sequence:
MEARSLKHSLIGLNMNSTHINMDLSLTHEPANMQSQFGSFQNYDQFSAAGYSSTPLYITKPTGVGAITKVAPHCSQNKIETNSTDNSIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVPYCYTSDANYTGIQNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDYIEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCGETCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTSCVLKFASQVLYTMWQHNELRDVYKKNGWKEQDFVSKHFTAHNTPPSSPNNVNNTLNRPMASQGRTRYEDRTIQRGTSTLYSANDSSGAVMSNESAMLSEMVRKQL