wanglab/gogpt-training-data huggingface dataset:
Protein: Neuroepithelial cell-transforming 1 (Neuroepithelial cell-transforming gene 1 protein isoform X2) (Q5RHT9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MMQCHRRQSYTRLGVWPSLRRGSSFTFLTPGPQWDFTLKRKRREKDDADAVSLCSFDFKEPCTKRVRPLGRVTSLANLISPVKNGAVRRFGQTLQASFRGDGRSPGVPQQKPCSKAAAPTPPKRRNSTLWSETLDVHQKGTFSTKEIKRQEAIFELSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTAIFGDLDAYIPLHEDLLDQLAKATGTDGTVRQIGKIVVDWLPRLNAYRAYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHTPPDHPDKGSLEQAISVIQAVLADINMKKGESECQYYIDKLEYLEDKQKDPRIEQCKSLLCHGELRNKSGTKLHVFLFTEVLILTRPVTRNDRHCFQVYRQPIPVQDLVLEDLQDGDVRMGGSFRGAFSNADKAKNIFRVRFQDASQGQSHTLQVNDVFHKQQWLNCLRNAMSTQKDLTLSENEPLTTPATDVCAKRRSSSVSTVIQMDEMDENCPRAAASAPSSPSSEEPPSPTPSATSTLSSSSSSSSISAPIPSRKSKKDKRSLCPLGKRKETMV
Protein: Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed] (P24050)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P46782}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P46782}.
Interaction partners:
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS9
- Ubiquitin-ribosomal protein eL40 fusion protein
- Large ribosomal subunit protein uL3
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS19
Sequence:
MTEWETATPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAANGFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINARKGSSNSYAIKKKDELERVAKSNR
Protein: Uncharacterized protein LOC792578 (cDNA, clone cssl:d0834) (A4JYS5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGCTGRRILWLGCLVSMFLQYGAVRVTVRESSLEVVQGDSVTLPCSFFTMMPLFRLSIIWTLTPLSDPNSPIQVIVYDQGQVTENPSFMGRVGFAGMPWSADIILNYTRVSDAGVYRCVVSNPPETGDPGIGELSLTVLAPPSLPMCLWEGDTDTGGNVRLSCVVAEGFPTPQVIWEKLEPDKMTLPVNMDGDMTGSVHIANVSTQSSGLYRCSVTNSLGTQHCYINLSVYTPPDNSPGILQGVLLSLSMALLLLALMVLVLWLHRSAQESKWRNSHEEDDCYNEIKYTPSLIKRSFV
Protein: Vomeronasal 2, receptor 74 (A0A3B2WAR9)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MFFLNSVFWLLKISFNFGHLSDPRCFWRIKDTENKLGDKETYCFFTISTKHGYVKNDYFRWNLDKKVTPKTRHLIFSVYLALEEINKNCHILPNISLVVNIECVLDKHDEKTDFLFKSEDLIPNYYCKNERRYLIVLTAPLWAVSSSIGPYLFMSRIPEISRKDTFLPLAMVSLVVHFRWNWIGVIVTNDDHGIQFLSEFRGEMQNKIVCLSFAIIIKTGKFLAVTELHMNYKQILMSSAKVVIVYGYRDSPIIYAFIVWKSQDLFRIWVSVSQLDMITFLGDFLLYASTGTFIFSHQKPEISGFEQFIQRIHPSNYSSEFSLAKQWWTYFRCSLPPSNCKKLKNCSTKTVFKWLFMTPLGLAMSDTCYNIYNAMYAVAHSLHGMLLQQVDTWSKNAGKELEFDSWKMFSILKTLKFVNPAGDLVNMNQNLKQDVEFDVFYIMDFQKDYGLKMKIGRFSEHLPSGQQIYMSKEMIEWATDIDQILPSICTMPCRPGLRKSPQEGKDICCFDCKPCSENEVSNMTNMDQCVKCPEDQYANEDHTVCLQKVVTILDYRDPLGKALAGFALCFSVLTSLVLVVFLKHRDTPIVKANNQTLSFVLLISLIFCFICSLLYIGHPTMAICILQQTTFAIVFTVATSTILSKTVIVILAFKITVPGRRMRWLLESGTPKYIIPICTIIQLILCGIWLGTSPPFVDADLHMVHGHILIVCNKGSVIAFYCVLGYMGSVALASFTVAFLARNLPDTFNEAKLLTFSMLVFCSVWITFIPVYHSTKGKTMVAVEVFCILASSAGLLLCIFAPKCYIILLRPQKNYFYKFRKRRELNLTT
Protein: Uncharacterized protein (Q388K3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Bromo domain-containing protein
- TATA box-binding protein-like 1
- Trans sialidase, putative
- Plastid-encoded RNA polymerase subunit alpha
- DNA-directed RNA polymerase subunit beta
- DNA 5'-3' helicase
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-direcetd RNA polymerase II, subunit 9, putative
- RNA polymerase-like protein
- [RNA-polymerase]-subunit kinase
Sequence:
MAQVGEVSTGTVTLDDEWTRGEATACGEAYAKVDDMDYDSFQRVVQKNRERGMPPPPRAVLKRVPESSDDFLRNFFLRNGMHRTMDIFEIEWYEKYGSKPLKDAPVFADNYLETAALHNRIDVLENQLRQHAELTTKTTKQFLQSKKERDFHRANHNRVVQEKNKLLKLLRQAQSHAEDLNPTLNELRQKCEALHKGKTMLSIERDKLEAKVLKLEKQVESLEQQLKLHETTRTKEPSPRQRDKQVAKVDGTKSGTKGGKSATRAGDAAADTFRWPPDERRRPANASGAFLAPTEPSSWICQSSFKAHSMPVTKIAMHPEKPAVVTSSDDGTWRLSALPQGELVMSGDGHKSWVSSVVMHPTGTMVATASGDKTVKLWDFAKNGCRLTLKAHCDGVWCLDFQETGLLLASGSLDQTARVWDVTTGKCRQTLRGHVDAVNGVAWRQYTNTLCTVSGDKTVSLWDVRANCCSQTLYGHRNAVQSVTTVGPTTNVATCDADGVVMLWDTRRMEQHLTVACGPYPANHIASDRNGTYLLVSSDDTNIKLIDVTKSTVTELVGHEDGVQCAVFDWSSNAFIVSGGSDGVVRYWC
Protein: Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) (Q96P16)
Organism: Homo sapiens (Human)
Function: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
Subcellular location: Nucleus {ECO:0000269|PubMed:22231121}.
Interaction partners:
- Regulation of nuclear pre-mRNA domain-containing protein 1B
- Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB4
- Decapping and exoribonuclease protein
- 5'-3' exoribonuclease 2
- DNA-directed RNA polymerase II subunit GRINL1A
- DNA-directed RNA polymerase II subunit RPB11-a
Sequence:
MSAFSEAALEKKLSELSNSQQSVQTLSLWLIHHRKHSRPIVTVWERELRKAKPNRKLTFLYLANDVIQNSKRKGPEFTKDFAPVIVEAFKHVSSETDESCKKHLGRVLSIWEERSVYENDVLEQLKQALYGDKKPRKRTYEQIKVDENENCSSLGSPSEPPQTLDLVRALQDLENAASGDAAVHQRIASLPVEVQEVSLLDKITDKESGERLSKMVEDACMLLADYNGRLAAEIDDRKQLTRMLADFLRCQKEALAEKEHKLEEYKRKLARVSLVRKELRSRIQSLPDLSRLPNVTGSHMHLPFAGDIYSED
Protein: E3 ubiquitin-protein ligase TRIM8a isoform X1 (Tripartite motif-containing 8a) (E7FCI6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Synaptonemal complex protein 1
Sequence:
MSDQMAEMAESWRNCFEEELICPICLHVFVEPVQLPCKHNFCRGCISEAWAKDAANVRCPECNHAYSQKPNLEKNIKLNNIVEKFNALNVEKAPSVLHCILCRRGPPLQAQKVCLRCNAPCCQSHIQTHLQQPCPAPGHLLVATEEVRAWSCPHHDEYRLYHCDVEQVSVCKYCCFSRCAPNHGHAVCDVEVRRNDIRHMLMKQQDRIDDRVKDIEEQLYKLESDKLLVEDKVRQLKEEVRVQYHKMHQLLEDDLGRTLEVLDKAHSKYCQESSTQTLQLNERRQEAKKLLSSVQVVFDKAEDINIMKNTKPVKILMDRSQSCTGSVLPPYKVGHLNSKIFLSEVSKKEKNLRKVLEAPFSTPAHFLQSISVHPSSVNPTGGEKRKHSTAFPESSTSLLESSTGPMSKQQFLAPGSSDGATAQTTIAPCSSAQHIVGLSSGTGGGAAQSVHHSSSVFTSADYSNPSSSQQAMLPQYGGRKILMCTMDNCYCSSVPSISNHRTHPPYSRSGSFPWTQDYSHPLPSTPSMSQPLQGLSMHDWIDASQSHRHPDFYGLYGQSSTKPYVTS
Protein: Carboxypeptidase B (EC 3.4.17.2) (P19223)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted {ECO:0000250|UniProtKB:P00732}. Zymogen granule lumen {ECO:0000250|UniProtKB:P55261}.
Interaction partners:
- Chymotrypsinogen B
- Chymotrypsin like elastase 3B
- Chymotrypsin-like elastase family member 2A
- Cationic trypsin-3
- Pancreatic triacylglycerol lipase
- Proteasome 20S subunit beta 10
- Carboxypeptidase A1
- Bile salt-activated lipase
- Carboxypeptidase B2
- Inactive pancreatic lipase-related protein 1
Sequence:
MLLLLALVSVALAHASEEHFDGNRVYRVSVHGEDHVNLIQELANTKEIDFWKPDSATQVKPLTTVDFHVKAEDVADVENFLEENEVHYEVLISNVRNALESQFDSHTRASGHSYTKYNKWETIEAWIQQVATDNPDLVTQSVIGTTFEGRNMYVLKIGKTRPNKPAIFIDCGFHAREWISPAFCQWFVREAVRTYNQEIHMKQLLDELDFYVLPVVNIDGYVYTWTKDRMWRKTRSTMAGSSCLGVRPNRNFNAGWCEVGASRSPCSETYCGPAPESEKETKALADFIRNNLSTIKAYLTIHSYSQMMLYPYSYDYKLPENYEELNALVKGAAKELATLHGTKYTYGPGATTIYPAAGGSDDWSYDQGIKYSFTFELRDTGFFGFLLPESQIRQTCEETMLAVKYIANYVREHLY
Protein: Possible bifunctional enzyme long-chain acyl-CoA synthase and lipase (O33185)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- UPF0434 protein Rv1684
- Aromatic amino acid aminotransferase
- Probable fatty acid synthase Fas
- Uncharacterized transporter Rv0917
- Probable conserved proline, glycine, valine-rich secreted protein
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Probable multifunctional mycocerosic acid synthase membrane-associated Mas
- Mycocerosic acid synthase-like polyketide synthase
- Mycoketide-CoA synthase
- Phthioceranic/hydroxyphthioceranic acid synthase
Sequence:
MVDLNFSMVTRPIERLVATAQNGLEVLRLGGLETGSVPSPSQIVESVPMYKLRRYFPPDNRPGQPPVGPPVLMVHPMMMSADMWDVTREDGAVGILHASGLDPWVIDFGSPDEVEGGMRRNLADHIVALSEAVDTVKDATGHDVHFVGYSQGGMFCYQAAAYRRSKDIASVVAFGSPVDTLAALPMGIPANMGAAVADFMADHVFNRLDIPSWMARMGFQMMDPLKTAKARVDFVRQLHDREALLPREQQRRFLESEGWIAWSGPAISELLKQFIAHNRMMTGGFAISGQMVTLTDITCPILAFVGEVDDIGQPASVRGIRRAAPNSEVYECLIRAGHFGLVVGSRAAQQSWPTVADWVRWISGDGTKPENIHLMADQPAEHTDSGVAFSSRVAHGIGEVSEAALALARGAADAVVAANRSVRTLAVETVRTLPRLARLGQLNDHTRISLGRIIDEQAHDAPKGEFLLFDGRVHTYEAVNRRINNVVRGLIAVGVRQGDRVGVLMETRPSALVAIAALSRLGAVAVVMRPDTDLSASVRLGRVTEILTDPTNLDAARQLPGQVLVLGGGESRDLDLPADALEQGQVIDMEKIDPDAVELPAWYRPNPGLARDLAFIAFSSADGDLVAKQITNYRWAVSAFGTASTAALGRRDTVYCLTPLHHESALLVSLGGAVVGGTRIALSRGLRPDRFVAEVRQYGVTVVSYTWAMLRDVVDDPAFVLHGNHPVRLFIGSGMPTGLWERVVEAFAPAHVVEFFATTDGQAVLANVAGAKIGSKGRPLPGAGRVELGAYDAEHDLILENDRGFVQVAGVNQVGVLLAQSRGPIDPTASVKRGVFAPADTWISTDYLFWRDDDGDYWLAGGRGSVVRTARGMVYTEPVTNALGLITGVDLAVTYGVLVRGRHVAVSAVTLLPGATITAADLTEAVASMPVGLGPDIVHVVPQLTLSGTYRPTVSALRANGIPKAGRQAWYFNSGGNEYRRLTPAVRTELTGQHRRGNA
Protein: Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) (Q8WU90)
Organism: Homo sapiens (Human)
Function: Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15676025, ECO:0000269|PubMed:19819225}. Nucleus {ECO:0000250}. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.
Interaction partners:
- Developmentally-regulated GTP-binding protein 1
- Developmentally-regulated GTP-binding protein 2
- RWD domain-containing protein 1
- Ubiquitin-like protein FUBI
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein eS12
- DnaJ homolog subfamily C member 2
- Small ribosomal subunit protein RACK1
- Small ribosomal subunit protein uS5
Sequence:
MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCKHFLEAIENNKYGWFWVCPGGGDICMYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYTQGTGGDEVDDSVSVNDIDLSLYIPRDVDETGITVASLERFSTYTSDKDENKLSEASGGRAENGERSDLEEDNEREGTENGAIDAVPVDENLFTGEDLDELEEELNTLDLEE
Protein: Nitrogen fixation regulatory protein (P06772)
Organism: Klebsiella pneumoniae
Function: Required for the inhibition of NifA activity in response to oxygen and low level of fixed nitrogen.
Interaction partners:
Sequence:
MTLNMMLDNAVPEAIAGALTQQHPGLFFTMVEQASVAISLTDARANITYANPAFCRQTGYSLAQLLNQNPRLLASSQTPREIYQEMWQTLLQRQPWRGQLINQARDGGLYLVDIDITPVLNPQGELEHYLAMQRDISVSYTLEQRLRNHMTLMEAVLNNIPAAVVVVDEQDRVVMDNLAYKTFCADCGGKELLVELQVSPRKMGPGAEQILPVVVRGAVRWLSVTCWALPGVSEEASRYFVDSAPARTLMVIADCTQQRQQQEQGRLDRLKQQMTAGKLLAAIRESLDAALIQLNCPINMLAAARRLNGEGSGNVALDAAWREGEEAMARLQRCRPSLELESNAVWPLQPFFDDLYALYRTRFDDRARLQVDMASPHLVGFGQRTQLLACLSLWLDRTLALAAELPSVPLEIELYAEEDEGWLSLYLNDNVPLLQVRYAHSPDALNSPGKGMELRLIQTLVAYHRGAIELASRPQGGTSLVLRFPLFNTLTGGEQ
Protein: Dodecaprenyl-phosphate galacturonate synthase (Dod-P-GalA synthase) (EC 2.4.1.-) (Dodecaprenyl-phosphate galacturonosyltransferase RgtE) (Galacturonic acid transferase RgtE) (GalA transferase RgtE) (GalAT RgtE) (Q1MJ95)
Organism: Rhizobium johnstonii (strain DSM 114642 / LMG 32736 / 3841) (Rhizobium leguminosarum bv. viciae)
Function: Glycosyltransferase that catalyzes the synthesis of dodecaprenyl-phosphate galacturonate (Dod-P-GalA), likely from UDP-GalA and dodecaprenyl-phosphate. Dod-P-GalA is the lipid donor required for GalA transfer to lipopolysaccharide (LPS) specific residues catalyzed by the GalA transferases RgtA, RgtB, RgtC and RgtD.
Subcellular location: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MQTTVEPIRGTNDPVQSLELSLVVPIFNEEQSVGPLVERVAAAMVSYPHRWELILVDDGSTDATLVNARKYVGREGLALRIVELQRNFGQTAAMQAGIDTARGRLIATMDGDLQNDPKDIPSMVSELERRELDLLVGWRKNRKDGLFLRKIPSWCANYLIGRITGVKLHDYGCSLKIYRASIIKQVKLMGEMHRFIPAWVAGVVPSSRIGEMAVTHHAREHGVSKYGISRTFRVILDLLSVMFFMRYKARPGHFFGSLGLGLGALAMLILLYLGFDKFILGNDIGTRPMLMVGVVLLLSSVQMITTGILAEMIARTYYRDDASPNYIVRQIFDDQSQA
Protein: Interferon regulatory factor 9 (H0YMB0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDVAEPYKVYQLLPPGIVSGQPGTQKVPSKRQHSSVSSERKEEEDAMQNCTLSPSVLQDSLNNEEEGASGGAVHSDIGSSSSSSSPEPQEVTDTTEAPFQGDQRSLEFLLPPEPDYSLLLTFIYNGRVVGEAQVQSLDCRLVAEPSGSESSMEQVLFPKPGPLEPTQRLLSQLERGILVASNPRGLFVQRLCPIPISWNAPQAPPGPGPHLLPSNECVELFRTAYFCRDPPCSLCMALLRLCVAYPVWPYAQPGSYLAALLQPRQWKRWFRLGQVLSGPGPPTEVPGNTEFLGREPWLQPYSTESYHSEDGAGLCPILAGADSRAAGSHSVPGVEPGGPIFHLTSLFFLSPLK
Protein: N-myc downstream regulated gene 4 (Q1JPS5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MPECWDGEHDIETPYGMLHVVIRGAPKGNKPAILTYHDVGLNHKLCFNSFFQNEDMLEITKHFVVCHVDAPGQHIGAPQMPQGYQYPTMDQLAGMLPSVVQHFGFKSIVGIGVGAGAYILAKFALIFPDLVEGLVLLNIDPNGKGWIDWAATKLSGLTSTLPDTVLTHLFSQEELMSNTEVVQNYRQQINNTINQFNLQLFWNMYNSRRDLEMNRSGSVINAKTLRCPVMLVVGDNAPAEEGVVECNSKLDPTNTTFLKMADSGGMPQITQPGKLTEAFKYFLQGMGYIAYMKDRRMSGGPVPSASMTRLARSRTASLTSASSVDGSRNRACTHSDSSEGVGQVSHTMEVSC
Protein: Manganese transport regulator (I1ZJY9)
Organism: Streptococcus parasanguinis FW213
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- DUF3114 domain-containing protein
Sequence:
MTPNKEDYLKCIYEIGTEVEKISNKEIASRMQVSPPAVTEMIKRMISEGLLVKDKTHGYLLTDLGSQLVSDLYRKHRLIEVFLLENLGYTTEEVHEEAEVLEHTVSEHFIDRLDHMLGNPKTCPHGGTIPKKGERLVEAHQDRLSETTQPGLYILQRVYDTYELLKFLDQIHLQIGDTIAFQRYDDYTGLYHFVIHGQEISINQVIAQQLYIEKHAV
Protein: Tol-Pal system protein TolQ (P0ABU9)
Organism: Escherichia coli (strain K12)
Function: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. The Tol-Pal system is also required for polar localization of chemoreceptors clusters. The system also appears to be required for the activity of several outer membrane-localized enzymes with cell wall remodeling activity. Is involved in the uptake of group A colicins (colicins A, E1, E2, E3, and K) and in the uptake of filamentous phage DNA.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02202, ECO:0000269|PubMed:8300535, ECO:0000269|PubMed:8331075}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02202, ECO:0000269|PubMed:8300535, ECO:0000305|PubMed:8331075}. Note=Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity. {ECO:0000269|PubMed:17233825}.
Interaction partners:
- Tol-Pal system protein TolR
- Tol-Pal system protein TolB
- Acyl-CoA thioester hydrolase YbgC
- Peptidoglycan-associated lipoprotein
- Biopolymer transport protein ExbD
- Cell division coordinator CpoB
- Tol-Pal system protein TolA
- Outer membrane protein assembly factor BamD
- Outer membrane protein assembly factor BamA
- Lipoprotein-releasing system transmembrane protein LolE
Sequence:
MTDMNILDLFLKASLLVKLIMLILIGFSIASWAIIIQRTRILNAAAREAEAFEDKFWSGIELSRLYQESQGKRDNLTGSEQIFYSGFKEFVRLHRANSHAPEAVVEGASRAMRISMNRELENLETHIPFLGTVGSISPYIGLFGTVWGIMHAFIALGAVKQATLQMVAPGIAEALIATAIGLFAAIPAVMAYNRLNQRVNKLELNYDNFMEEFTAILHRQAFTVSESNKG
Protein: Sensor histidine kinase EnvZ (EC 2.7.13.3) (Osmolarity sensor protein EnvZ) (P0AEJ4)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals; at low osmolarity OmpR activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. Also dephosphorylates OmpR in the presence of ATP. The cytoplasmic dimerization domain (CDD) forms an osmosensitive core; increasing osmolarity stabilizes this segment (possibly by its contraction), enhancing the autophosphorylation rate and consequently, downstream phosphotransfer to OmpR and signaling. Autophosphorylation is greater when full-length EnvZ is reconstituted in a lipid environment, lipid-mediated allostery impacts the kinase function of EnvZ. Involved in acid stress response; this requires EnvZ but not OmpR phosphorylation, and suggests that EnvZ senses cytoplasmic acidic pH.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:1323560, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2824492}; Multi-pass membrane protein {ECO:0000305|PubMed:1323560, ECO:0000305|PubMed:15919996, ECO:0000305|PubMed:2824492}.
Interaction partners:
- DNA-binding dual transcriptional regulator OmpR
- Transcriptional regulatory protein CpxR
- Modulator protein MzrA
- Outer membrane porin C
- Outer membrane porin F
- Transcriptional regulatory protein PhoP
- Phosphate regulon transcriptional regulatory protein PhoB
- Aerobic respiration control sensor protein ArcB
- Aerobic respiration control protein ArcA
- Transcriptional regulatory protein BaeR
Sequence:
MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTTKEG
Protein: Cytochrome c biogenesis Fn (Q2F962)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MSINEFSHYLLFPGLFVAFTYNKKQPPAFGAAPAFWCILLPFLGLSFRHIPNNLSNYNVLTANASFFYQISGAWSNHEGSILSWCWIPSFYGFLFCYRGRPQSHNVSKRRGYRETFIFSFVSNFVKNSILSLQQKSGAAPQLYTPFVRRTFVDSELRSQSKRPFNGPALFNAPLDPVLKMSFALLGAGRSRGSREGKRTNLLLHLARDEKERASSIDEQQIDGALGIALFFSSFLSASSDPFVRNFFVRTEPLAESNPVPQDPISAIHPPCIYAGDVASAMGFGLCRSKMMNGIVALHSPPMRKDAAEKNGTLLRSAGCVGSHIRSSLFTRSFKHFVGGAPALLLRSNRSLLMLLRRRFFAFSSLWTGALMDTGREQAKRVVRNGKKDTTTSPLCWTAGANTVVSDQDQEPIRIWILTCRLFLTVGISPGSWWAHHELGRGGWWFRDPVENASFMPRVLATARIHSVILPLLHSWTSLLNILTLPCCVSGTFSIRSGLLAPVHSSATDDTRGRFLWRFFLLITGISMTLFYQMKQEASVRRTYKKEMVVARSTLVHLRHSARAQPRPVMLWKNLAYCWAGYSEPATGCRISSRP
Protein: Type 3 secretion system regulator YopR (T3SS regulator YopR) (Yersinia outer protein R) (Yersinia secretion protein H) (Q01249)
Organism: Yersinia enterocolitica
Function: Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function.
Subcellular location: Secreted {ECO:0000269|PubMed:10209737, ECO:0000269|PubMed:17050689, ECO:0000269|PubMed:18976277, ECO:0000269|PubMed:8709853}. Note=Secreted via the type III secretion system (T3SS) (PubMed:10209737, PubMed:17050689). Mostly secreted into the extracellular milieu (PubMed:10209737). Secretion requires the presence of two elements, the N-terminal or 5' signal (positioned at codons 1-11) and an mRNA motif that resides within codons 131-149 (PubMed:17050689, PubMed:18976277). {ECO:0000269|PubMed:10209737, ECO:0000269|PubMed:17050689, ECO:0000269|PubMed:18976277, ECO:0000305|PubMed:8709853}.
Interaction partners:
Sequence:
MTVTLNRGSITSLMSSSQAVSTLQPAASELKTQLEHKLKSESAEKTREVLWQQYYASNPPDHAVLEVLATPVREALLARFGQHQGPVVPAIDLPELRSVLQQFDSFGKRREAILLQVLEGIKPNESQVGLPYLSELINKELMILLPYNSIVDSLLHNSHQIDMET
Protein: Synaptophysin (Major synaptic vesicle protein p38) (P07825)
Organism: Rattus norvegicus (Rat)
Function: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q62277}; Multi-pass membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:P08247}.
Interaction partners:
- Vesicle-associated membrane protein 2
- Synaptic vesicle glycoprotein 2A
- Synapsin-1
- Ras-related protein Rab-3A
- Multifunctional fusion protein
- Synaptotagmin-1
- Vesicular glutamate transporter 1
- Disks large homolog 4
- Glial fibrillary acidic protein
- Neuromodulin
Sequence:
MDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFMRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPASGGGGYGPQGDYGQQGYGQQGAPTSFSNQM
Protein: Adenylylsulfate reductase subunit alpha (AdoPSO(4) reductase subunit A) (EC 1.8.99.2) (Adenosine 5'-phosphosulfate reductase subunit alpha) (APSR subunit A) (T2G6Z9)
Organism: Megalodesulfovibrio gigas (strain ATCC 19364 / DSM 1382 / NCIMB 9332 / VKM B-1759) (Desulfovibrio gigas)
Function: Catalytic subunit of the adenylylsulfate reductase which catalyzes reversibly the reduction of adenosine 5'-phosphosulfate (APS) to sulfite and AMP during dissimilatory sulfate reduction.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7240092}.
Interaction partners:
- Adenylylsulfate reductase subunit beta
- Pyruvate:ferredoxin oxidoreductase
- Sulfite reductase, dissimilatory-type subunit alpha
- Sulfite reductase, dissimilatory-type subunit beta
- sulfate adenylyltransferase
- Putative Fumarate reductase respiratory complex
- Putative fumarate reductase respiratory complex
- Fumarate reductase iron-sulfur subunit
- Fumarate reductase iron-sulfur subunit
- Putative methyl-viologen-reducing hydrogenase subunit delta
Sequence:
MPKIPSKETPRGVAIAEPIIVEHSVDLLMVGGGMGNCGAAFEAVRWADKYAPEAKILLVDKASLERSGAVAQGLSAINTYLGDNNADDYVRMVRTDLMGLVREDLIYDLGRHVDDSVHLFEEWGLPVWIKDEHGHNLDGAQAKAAGKSLRNGDKPVRSGRWQIMINGESYKVIVAEAAKNALGQDRIIERIFIVKLLLDKNTPNRIAGAVGFNLRANEVHIFKANAMVVACGGAVNVYRPRSVGEGMGRAWYPVWNAGSTYTMCAQVGAEMTMMENRFVPARFKDGYGPVGAWFLLFKAKATNCKGEDYCATNRAMLKPYEERGYAKGHVIPTCLRNHMMLREMREGRGPIYMDTKTALQTSFATMSPAQQKHLEAEAWEDFLDMCVGQANLWAATNCAPEERGSEIMPTEPYLLGSHSGCCGIWASGPDEAWVPEDYKVRAANGKVYNRMTTVEGLWTCADGVGASGHKFSSGSHAEGRIVGKQMVRWYLDHKDFKPEFVETAEELKTLIYRPYYNYEKGKGASTCPVVNPEYISPKNFMMRLIKCTDEYGGGVGTYYNTSKALLDTGFWLMEMLEEDSLKLAARDLHELLRCWENYHRLWTVRLHMQHIAFREESRYPGFYYRADFLGLDDSKWKCFVNSKYDPAKKETKIFKKPYYQIIPTDA
Protein: Neurotensin receptor type 1 (NT-R-1) (NTR1) (O88319)
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P30989}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30989}. Membrane raft {ECO:0000250|UniProtKB:P30989}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000250|UniProtKB:P30989}.
Interaction partners:
- Neurotensin/neuromedin N
- Beta-arrestin-1
- Neurotensin receptor type 2
- Neuromedin-U
- Beta-arrestin-2
- Sortilin
- Coatomer subunit alpha
- Guanine nucleotide-binding protein G
Sequence:
MHLNSSVQQGAPSEPGAQPFPHPQFGLETMLLALSLSNGSGNSSESILEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQNRSADGQHPGGLVCTPTVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANKLTVMVHQAAEQGRGVCTVGTHNSLEHSTFNMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRRRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
Protein: Sorting nexin (F7FPM8)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MMITDQAPETLKSINVDLQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT