wanglab/gogpt-training-data huggingface dataset:
Protein: Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) (Q9Y283)
Organism: Homo sapiens (Human)
Function: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, cilium {ECO:0000269|PubMed:12872123}. Note=Associates with several components of the cytoskeleton including ciliary, random and polarized microtubules. During mitosis, it is recruited to mitotic spindle. Frequently membrane-associated, membrane localization is dependent upon cell-cell contacts and is redistributed when cell adhesion is disrupted after incubation of the cell monolayer with low-calcium/EGTA medium.
Interaction partners:
- Segment polarity protein dishevelled homolog DVL-1
- Nephrocystin-3
- Nephrocystin-1
- Nephrocystin-4
- Serine/threonine-protein kinase Nek8
- Segment polarity protein dishevelled homolog DVL-2
- Segment polarity protein dishevelled homolog DVL-3
- Serine/threonine-protein kinase Nek9
- Ankyrin repeat and SAM domain-containing protein 6
- Calmodulin-1
Sequence:
MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRGSPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVEKSRGETAGDERCAKGKGFVKQPSCIRVAGPDEKGEDSRRAAASLPPHDSHWKPSRRHDTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGSARGEAVHAGQNPPHHRTPRNKVTQAKLTGGLYSHLPQSTEELRSGARRLETSTLSEDFQVSKETDPAPGPLSGQSVNIDLLPVELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQESTALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHEGKIHHPTRSVKASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTKP
Protein: Uncharacterized protein (Q384N9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Ribosomal protein S23 mitochondrial conserved domain-containing protein
- Trans-sialidase
- Uncharacterized protein
- Rhodanese domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- 30S ribosomal protein S8, putative
- Uncharacterized protein
Sequence:
MQVTETVLARAVIKRRSPQLWGAPGAPIIRMRGHHVVWKFQSYDLVVEHTHKRRNSDIRLLHYLGKHCPHPQKSLWSPDTPVAQDRHLFMLTTVDIDAFKYWFGVKRCRLSMKPWALLAKAGLLPPSLTQNSKIMPKPLFDKESLMRYYLANRKDEDVMAREKYLNYENSMVKTEEERAAERPVAPYL
Protein: Small acidic protein 2 (Q1ECS0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates responses to the synthetic auxin 2,4-dichlorophenoxyacetic acid (2,4-D). Not involved in the response to indole-3-acetic acid (IAA). May interact with RUB modification-related components and may regulate the culling-ring ubiquitin E3 ligase complex (CRL) activity.
Interaction partners:
- Small acidic protein 1
Sequence:
MDRYWEQDPMRPMVYRDFLGEMEYPGYSMPMQMEIDEDDFGPMDMQFEVGGISPFQMKPEDSDFFNKFEDDFDDSDIN
Protein: Strigolactone esterase RMS3 (EC 3.1.-.-) (Protein DWARF 14 homolog) (PsD14) (Protein RAMOSUS 3) (A0A109QYD3)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Involved in strigolactone signaling pathway. Functions downstream of strigolactone synthesis, as a component of hormone signaling and as an enzyme that participates in the conversion of strigolactones to the bioactive form. Binds and hydrolyzes the synthetic strigolactone analog GR24 and its enantiomers in vitro. Forms a stable covalent complex with the D-ring of strigolactone, which is essential for hormone bioactivity. The D-ring is attached to His-247 of the catalytic triad. The hydrolysis of strigolactone into a covalently linked intermediate molecule is required to trigger strigolactone signaling. This mechanism defines RMS3 as a non-canonical hormone receptor with dual functions to generate and sense the active form of strigolactone. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds (Probable).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9SQR3}. Nucleus {ECO:0000250|UniProtKB:Q9SQR3}.
Interaction partners:
Sequence:
MGTPILDAFNVRVEGSGDKYLVFAHGFGTDQSAWQRVLPYFTRSYKVILYDLVCAGSVNPDHFDFRRYTTLDAYVDDLLNILDSLHVTRCAYVGHSISAMTGMLASIRRPELFSKLILIGASPRFLNDGENYHGGFEQGEIEHVFSAMEANYEAWVNGFAPLAVGADVPTAVREFSRTLFNMRPDISLFVSRTVFNSDLRGILGLVNVPCCIMQTARDMSVPASVATYMKEHIGGKSTVQWLDTEGHLPHLSAPSYLAHQLEIALSQ
Protein: Uncharacterized protein (A0A060XBA6)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Troponin T type 2b
- Troponin T, slow skeletal muscle
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Troponin T, slow skeletal muscle
- Troponin T2e, cardiac
- Uncharacterized protein
- Troponin T type 3a
Sequence:
MSEKKMNSSRRGHLKSLMLAIAKDLLEKEAADLITEKAAFIAENCPAPVLSGGLPELQEMLKKLAQTIDKVDEDRYDAEAKVKKTDKEIEDLKMKVVEIQGIKKPALKKVRMSADAMLAALLGTKHKASMDFRANLKEVKKEVKEEEEVGDWRKNVDEQAGMDGRKKKFETA
Protein: Protein NIP100 (Protein NIP80) (P33420)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Motor-binding component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9658168}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:9658168}. Note=Localizes to spindle poles throughout the cell cycle.
Interaction partners:
- Nuclear migration protein JNM1
- Protein LDB18
- Centractin
- Dynein heavy chain, cytoplasmic
- Nuclear migration protein NUM1
- WD repeat-containing protein PAC11
- Protein BIM1
- Nuclear distribution protein nudE homolog 1
- Actin-like protein ARP10
- Nuclear distribution protein PAC1
Sequence:
MRNAGVQVDTNMQKISLQDTVLVNEMKGRVKFIGETQFAKGIWYGIELDKPLGKNDGSANGIRYFDIDLKKANSNGGYYGLFCKKDTLQFYKPDDDEHSLLNGNAAQETIKNLQVKCESLASKLNKIKIENHELKTSVEKLSTNETVLLSKISRLDKLVKELKVENGNMKTHLDNFNHLLDASDSVMAPDLDKGTLLERSHLLQGLLDQTKLSYDKAMKVQEDLLEENTQLLEENAVLSKKISDLGLQLQQTNNTIGDLALQIEAQSKSSNIVDKLTNDNILLTSNIKALNNELEELQAKEKLDENLRITYEQLEQELRLQLSNLQSALENEKEIAGTYIEENSRLKATLESIEAKTSHKFQSLELKVNTLQEELYQNKLLKKFYQIYEPFAQPHLAALSSQLQYLAEVIESENFGKLENIEIHIILKVLSSISYALHIYTIKNTPDHLETTLQCFKVNIAPISMWLSEFLQRKFSSKQETAFSICQFLEDNKFLDKDVTLILKILHPILETTVPKLLAFLRTNSNFNDNDTLCLIGSLYERSLSLIARIDKLIGKEEISKQDNRLFLYPSCDITLSSILTILFSDALFLRQDYKRISSLKKLEVFFQGIESLLENITIFPEQPSQQTSDSESQCNIKEGNFSNSLLSDRLNEENIRLKEVLVQKENMLTELETKIKIIIGRDLERKTLEENIKTLKVELNNKNEENCGKTEILNKLKEENFNLVNRLKNMELKLYQIKDNNTLNKIYLDREKVDRVNLVSEIMELRETIRRQIKEQKRVSIDFSWLDELPAVENKQPFKEHINHSLDTLGIEMFNFVSTSRILDLKLDQPLAEDELWHERDHSYISYLKRKRKNIRLKSQNVVTYYK
Protein: High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha) (P12371)
Organism: Rattus norvegicus (Rat)
Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P12319}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Interaction partners:
- High affinity immunoglobulin epsilon receptor subunit gamma
- High affinity immunoglobulin epsilon receptor subunit beta
- Tyrosine-protein kinase Fyn
- Ig-like domain-containing protein.
- Tyrosine-protein kinase SYK
- Mast cell carboxypeptidase A
- Chymase
Sequence:
MDTGGSARLCLALVLISLGVMLTATQKSVVSLDPPWIRILTGDKVTLICNGNNSSQMNSTKWIHNDSISNVKSSHWVIVSATIQDSGKYICQKQGFYKSKPVYLNVMQEWLLLQSSADVVLDNGSFDIRCRSWKKWKVHKVIYYKDDIAFKYSYDSNNISIRKATFNDSGSYHCTGYLNKVECKSDKFSIAVVKDYTIEYRWLQLIFPSLAVILFAVDTGLWFSTHKQFESILKIQKTGKGKKKG
Protein: Protein argonaute 2 (Q9SHF3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates mainly with siRNAs of 21 nucleotide in length and preferentially recruits small RNAs with a 5' terminal adenosine. Probably involved in antiviral RNA silencing. Associates with siRNA derived from cucumber mosaic virus (CMV). Targeted by turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO2 function in RNA silencing. Required to direct NERD-dependent DNA methylation and silencing.
Interaction partners:
- Endoribonuclease Dicer homolog 2
- Dicer-like protein 4
- Endoribonuclease Dicer homolog 1
- Endoribonuclease Dicer homolog 3
- RNA-dependent RNA polymerase 6
- Protein DCL homolog, chloroplastic
- DNA-directed RNA polymerase V subunit 1
- RNA-dependent RNA polymerase 2
- DNA-directed RNA polymerase IV subunit 1
- Small RNA 2'-O-methyltransferase
Sequence:
MERGGYRGGRGDGRGRGGRGYGGGGGGGEQGRDRGYGGGEQGRGRGSERGGGNRGQGRGEQQDFRSQSQRGPPPGHGGRGTTQFQQPRPQVAPQPSQAPASYAGSVGGVAGRGAWGRKPQVPSDSASPSTSTTVVSEPVRVAEVMNLKPSVQVATSDRKEPMKRPDRGGVVAVRRVNLYVNHYKVNFNPESVIRHYDVEIKGEIPTKKVSRFELAMVRDKVFTDNPDEFPLAMTAYDGQKNIFSAVELPTGSYKVEYPKTEEMRGRSYTFTIKQVNVLKLGDLKEYMTGRSSFNPRDVLQGMDVVMKEHPSKCMITVGKSFFTRETEPDEDFRFGVIAAKGYRHTLKPTAQGLSLCLDYSVLAFRKAMSVIEYLKLYFNWSDMRQFRRRDVEEELIGLKVTVNHRKNKQKLTIVGLSMQNTKDIKFDLIDQEGNEPPRKTSIVEYFRIKYGRHIVHKDIPCLDLGKNGRQNFVPMEFCDLVEGQIYPKDNLDKDSALWLKKLSLVNPQQRQRNIDKMIKARNGPSGGEIIGNFGLKVDTNMTPVEGRVLKAPSLKLAERGRVVREEPNPRQNNQWNLMKKGVTRGSIVKHWAVLDFTASERFNKMPNDFVDNLIDRCWRLGMQMEAPIVYKTSRMETLSNGNAIEELLRSVIDEASRKHGGARPTLVLCAMSRKDDGYKTLKWIAETKLGLVTQCFLTGPATKGGDQYRANLALKMNAKVGGSNVELMDTFSFFKKEDEVMFIGADVNHPAARDKMSPSIVAVVGTLNWPEANRYAARVIAQPHRKEEIQGFGDACLELVKAHVQATGKRPNKIVIFRDGVSDAQFDMVLNVELLDVKLTFEKNGYNPKITVIVAQKRHQTRFFPATNNDGSDKGNVPSGTVVDTKVIHPYEYDFYLCSHHGGIGTSKPTHYYTLWDELGFTSDQVQKLIFEMCFTFTRCTKPVSLVPPVYYADMVAFRGRMYHEASSREKNFKQPRGASTSAASLASSLSSLTIEDKAIFKLHAELENVMFFV
Protein: Zinc finger transcription factor YY1 (Protein YIN YANG 1) (AtYY1) (Q2V3L3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Dual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3'. Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Interaction partners:
- Actin-related protein 4
- RuvB-like protein 1
- Protein EIN6 ENHANCER
- DNA-binding protein-like
- Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin carboxyl-terminal hydrolase 2
- SWR1-complex protein 4
- SWR1 complex subunit 2
- Histone-lysine N-methyltransferase ATX4
Sequence:
MDHQNYQYQNPFERRPILKSKAPAVKWIKEWVPQDIVATGGKCHLHKWVTEDTFSRLKEKEKEPDVPEPEPEPTTEILFLCSYDGCGKTFFDVSALRKHSHIHGERQYVCDQEGCGKKFLDSSKLKRHYLIHTGERNYICTYEGCGKAFSLDFNLRSHMKTHSQENYHICPYSGCVKRYAHEYKLKNHVAAYHEKNGGGETPKYTPPAEKVLRTVKTPATVCGPSSDRPYACPYEGCEKAYIHEYKLKLHLKREHPGHLQEENADTPTLNKHNGNDRNEIDDGSDQDVYRKHASNGKGQTHKQQSRAKPNMRTPPAKVGKKGSTSSPAKARIAKKPWQAKETFEEVEREEEEDSEETEEDRDNVEDGWRFGENNEDDDDDEETEYED
Protein: Zinc finger protein 16-like (Zinc finger protein 697-like) (A0A1D5NS60)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable transcription factor (Probable). Important for development and migration of oligodendrocyte precursor cells, and normal myelination of axons in the central nervous system (CNS). Functions autonomously in oligodendrocytes to promote CNS myelination. Seems to act in parallel with notch3 during oligodendrocyte development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MSRKRNHCYMETGASSESQGAFVDSAGPFSRDEEDFSELEPDEQLVCSVTEITEHLGRNITVVLESALSEIRKLVGVRIRVLKMELREKSDEIELLKAKLESAEKDGRVSNFSSLDFRKSEHQKYGAEPKKAKTGTPVVKKENINAICDYLMKDKNQRGAAEVESDHSNQAFGSERDVRTEAQPHGSLSLWPDSGPADTDAETDIFSMLPSASKRMYDYEWMTGVELNSAEFKGDSETKCEDVPPMDEEDENEDSEEGRGSLRSVSDHFPLDTQGSPGEDRSSPAEDSMDRMEPGQQFTSHTFICPFCGTLCPDSSFLEEHIKLMHHGESLLQSTSAGSSSQAEGDSGEAGPASRGAREKKVEGGYECGDCGRHFNYLGNLRQHQRIHTGEKPFVCPECGERFRHTARLKSHRLSHSGAQSPFPCPQCGKGFPVLSGLKRHQRVHTGESPYACPQCGRRFKELGNLYTHMRIHSGATPYTCYQCGRSFRHLGTYKSHRCMPATQMPSEHSPPWAQEDKVQTGRLQGYV
Protein: Aminopeptidase N (EC 3.4.11.2) (Alpha-aminoacylpeptide hydrolase) (P04825)
Organism: Escherichia coli (strain K12)
Function: Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
Subcellular location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Interaction partners:
- Cytosol aminopeptidase
- Cytosol non-specific dipeptidase
- Peptidase B
- Glutathione hydrolase proenzyme
- Glutamate--cysteine ligase
- Glutathione synthetase
- Glutathione-specific gamma-glutamylcyclotransferase
- Putative glutamate--cysteine ligase 2
- Peptidase T
- Aspartate aminotransferase
Sequence:
MTQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA
Protein: Agglutinin (CCA) (P82859)
Organism: Castanea crenata (Japanese chestnut)
Function: D-mannose/D-glucose-binding lectin. Binds N-linked high-mannose-type glycans. Has a preference for smaller (Man(2)-Man(6)) high-mannose-type glycans to larger (Man(7)-Man(9)) ones. Recognizes both alpha1-6 extended and alpha1-3 extended monoantennary glycans. The addition of alpha1-2Man to the Man-alpha1-3Man-beta branch results in a significant loss of affinity, but beta1-2GlcNAc has some affinity. Has less affinity for biantennary glycans, and affinity is very weak for the biantennary complex-type N-glycans with bisecting GlcNAc. No affinity is observed for tri- and tetra-antennary glycans. Has mitogenic and hemagglutinating activities.
Interaction partners:
Sequence:
MEEFLTVGLWGGEGGDRWSFVVNNGGIIGMEIVHANGIASITFKCGDEYGVLQHSRKFGGTGEGWKTDKISLNWPEEYLTSISGTVADLWQHIIIRSISFKTNKGTEYGPYGVVTGQPFSYSTEGGVIVGFHGRSGTLLDAIGAYVKIPQKKDNTLKMALPVPRGPGPWGGHGGMEWDDGVFPAIRELHLYVGDSVIHAIRVSYQSKDGEPLLSPKHGGEGGEPIDPIKLEVSKEFLIRIAGFYGPVEGSGSFKALRSITFYTNKAKYGPYGDEIGQAFTSSVAPGRVVGFHGRSGAYLDAIGVHMEYF
Protein: LIM domain-containing protein F (Q86I44)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Involved in the regulation of phagocytosis. May repress ChLim and activate rab21.
Interaction partners:
- Calponin homology and LIM domain-containing protein
- Ras-related protein Rab-21
Sequence:
MSGQNILKCKKCQLEITNKIITNHNSDTFHEQCFVCKLCSTPISDPYFTDKETGDFYCAKCEVIRNDQSKPLRESLGFCSLCYKYFRQNEDILTIDLERYHIGCLKCTICKKGINNEKYYREKMTSKLSNYCCEDCFEKVDKCNGCNSMTLGQTLLAMGKNYHANCFKCFKCSEIIKPNSPYSINKQTNTPSCQKCN
Protein: Adenine aminohydrolase (EC 3.5.4.2, EC 3.5.4.4) (E9AF40)
Organism: Leishmania major
Interaction partners:
- Adenosine kinase
- Adenosine kinase
- Adenosine kinase
- Putative inosine-adenosine-guanosine-nucleoside hydrolase
- adenine phosphoribosyltransferase
- Hypoxanthine phosphoribosyltransferase
- Guanine deaminase
- Nonspecific nucleoside hydrolase
- Adenylosuccinate synthetase
- Xanthine phosphoribosyltransferase
Sequence:
MADATLLHHLIEVLPKAELHVHIEGTLSPELLFELAKRNGVQIPYKTVEEVRVAYNFTDLQSFLDLYYEGMSVLITEDDFEDLAYAYTRVMHESRVVHAEPFFDPQGHLCRGVTFRVLYDGLMRGFRRGEAEFGVSVMLIFSFLRHLSEEECLALVLDDMHPDNGQYIRELFVAKAFVAVGLDSSELGHPPEKFARLYRYCREELKVPFLVAHAGEEGPPEYMRDAMSMLKVDRIDHGVAARLDQALCKDLREKRIPLTVCPTSNVALKVFQDRATCGAVVMDLILTEGLCVTINSDDPAYFGGDIRESFRILAETGRLTPATLKQLVLNSFSSSFIADDSKRAYKERVEKVFKDVCGGTYE
Protein: Protein Wnt-10b (Protein Wnt-12) (O00744)
Organism: Homo sapiens (Human)
Function: Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 5
- Low-density lipoprotein receptor-related protein 6
- Protein-serine O-palmitoleoyltransferase porcupine
- Wnt inhibitory factor 1
- Frizzled-1
- Frizzled-7
- Palmitoleoyl-protein carboxylesterase NOTUM
- Glypican-3
- Cerberus
- Frizzled-8
Sequence:
MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
Protein: Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) (P83887)
Organism: Mus musculus (Mouse)
Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19648910}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P23258}. Note=Mainly localizes to the centrosome, but a fraction is found outside of the centrosome in the cytoplasm (PubMed:19648910). Localizes to mitotic spindle microtubules (By similarity). {ECO:0000250|UniProtKB:P23258, ECO:0000269|PubMed:19648910}.
Interaction partners:
- Gamma-tubulin complex component 2
- Gamma-tubulin complex component 3
- Gamma-tubulin complex component 6
- Gamma-tubulin complex component 5
- Gamma-tubulin complex component 4
- Mitotic-spindle organizing protein 1
- Protein NEDD1
- Tubulin gamma-2 chain
- Mitotic-spindle organizing protein 2
- Serine/threonine-protein kinase PLK1
Sequence:
MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSSYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNLIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQFDKLRKREAFMEQFRKEDIFKDNFDEMDTSREIVQQLIDEYHAATRPDYISWGTQEQ
Protein: Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1) (P55347)
Organism: Homo sapiens (Human)
Function: Activates transcription in the presence of PBX1A and HOXA1.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Pre-B-cell leukemia transcription factor 1
- Pre-B-cell leukemia transcription factor 2
- Homeobox protein Hox-B1
- Homeobox protein Hox-B2
- Pre-B-cell leukemia transcription factor 4
- tRNA selenocysteine 1-associated protein 1
- Paired box protein Pax-6
- Glucocorticoid modulatory element-binding protein 1
- High mobility group protein B2
- Homeobox protein Hox-A1
Sequence:
MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALAPAHISGLVLENSDSLQ
Protein: Serine protease inhibitor Kazal-type 9 (Lymphoepithelial Kazal-type-related inhibitor 2) (Q5DT21)
Organism: Homo sapiens (Human)
Function: Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Kallikrein-5
- Kallikrein-8
- Serine protease inhibitor Kazal-type 14
Sequence:
MRATAIVLLLALTLATMFSIECAKQTKQMVDCSHYKKLPPGQQRFCHHMYDPICGSDGKTYKNDCFFCSKVKKTDGTLKFVHFGKC