wanglab/gogpt-training-data huggingface dataset:
Protein: Protein FAR-RED IMPAIRED RESPONSE 1 (Q9SWG3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator that recognizes and binds to the DNA consensus sequence 5'-CACGCGC-3'. Activates the expression of FHY1 and FHL involved in light responses. Positive regulator of chlorophyll biosynthesis via the activation of HEMB1 gene expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:10444599, ECO:0000269|PubMed:18033885}.
Interaction partners:
- Histone acetyltransferase subunit NuA4-domain protein
- AT-rich interactive domain-containing protein 3
- Protein FAR-RED-ELONGATED HYPOCOTYL 1-LIKE
- High mobility group B protein 15
- G-type lectin S-receptor-like serine/threonine-protein kinase SD3-1
Sequence:
MDLQENLVSDAGDDHMVDIVVEPHSNRDIGIVDEFNIGGDVGFSGDLDLEPRNGIDFDTHEAAYIFYQEYAKSMGFTTSIKNSRRSKKTKDFIDAKFACSRYGVTPESESSGSSSRRSTVKKTDCKASMHVKRRPDGKWIIHEFVKDHNHELLPALAYHFRIQRNVKLAEKNNIDILHAVSERTKKMYVEMSRQSGGYKNIGSLLQTDVSSQVDKGRYLALEEGDSQVLLEYFKRIKKENPKFFYAIDLNEDQRLRNLFWADAKSRDDYLSFNDVVSFDTTYVKFNDKLPLALFIGVNHHSQPMLLGCALVADESMETFVWLIKTWLRAMGGRAPKVILTDQDKFLMSAVSELLPNTRHCFALWHVLEKIPEYFSHVMKRHENFLLKFNKCIFRSWTDDEFDMRWWKMVSQFGLENDEWLLWLHEHRQKWVPTFMSDVFLAGMSTSQRSESVNSFFDKYIHKKITLKEFLRQYGVILQNRYEEESVADFDTCHKQPALKSPSPWEKQMATTYTHTIFKKFQVEVLGVVACHPRKEKEDENMATFRVQDCEKDDDFLVTWSKTKSELCCFCRMFEYKGFLCRHALMILQMCGFASIPPQYILKRWTKDAKSGVLAGEGADQIQTRVQRYNDLCSRATELSEEGCVSEENYNIALRTLVETLKNCVDMNNARNNITESNSQLNNGTHEEENQVMAGVKATKKKTVYRKRKGQQEASQMLESQQSLQPMETISSEAMDMNGYYGPQQNVQGLLNLMEPPHEGYYVDQRTIQGLGQLNSIAPAQDSFFTNQQAMSGMVGQIDFRPPPNFTYTLQEEHLSSAQLPGSSSRQL
Protein: F-box only protein 24 (O75426)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Interaction partners:
- S-phase kinase-associated protein 1
- NudC domain-containing protein 2
- Cullin-1
Sequence:
MGEKAVPLLRRRRVKRSCPSCGSELGVEEKRGKGNPISIQLFPPELVEHIISFLPVRDLVALGQTCRYFHEVCDGEGVWRRICRRLSPRLQDQGSGVRPWKRAAILNYTKGLYFQAFGGRRRCLSKSVAPLLAHGYRRFLPTKDHVFILDYVGTLFFLKNALVSTLGQMQWKRACRYVVLCRGAKDFASDPRCDTVYRKYLYVLATREPQEVVGTTSSRACDCVEVYLQSSGQRVFKMTFHHSMTFKQIVLVGQETQRALLLLTEEGKIYSLVVNETQLDQPRSYTVQLALRKVSHYLPHLRVACMTSNQSSTLYVTDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQMPLALSLPAKILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQRPITLWCGLNHSLVLSQSSEFSKELLGCGCGAGGRLPGWPKGSASFVKLQVKVPLCACALCATRECLYILSSHDIEQHAPYRHLPASRVVGTPEPSLGARAPQDPGGMAQACEEYLSQIHSCQTLQDRTEKMKEIVGWMPLMAAQKDFFWEALDMLQRAEGGGGGVGPPAPET
Protein: Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (ENR) (EC 1.3.1.39) (NADPH-dependent enoyl-ACP reductase) (Q2FZQ3)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It has a preference for a long chain (C12) substrate compared to the shorter (C4) acyl group. Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity).
Interaction partners:
- Malonyl CoA-acyl carrier protein transacylase
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- 3-oxoacyl-[acyl-carrier-protein] reductase
- Acyl carrier protein
- Beta-ketoacyl-[acyl-carrier-protein] synthase III
- Putative long chain fatty acid-CoA ligase VraA
- SDR family NAD
- 4'-phosphopantetheinyl transferase domain-containing protein
- Phosphate acyltransferase
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
Protein: Serine/threonine-protein kinase cek1 (EC 2.7.11.1) (P38938)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein.
Interaction partners:
- Serine/threonine-protein kinase ppk18
- Serine/threonine-protein kinase sck1
- cAMP-dependent protein kinase catalytic subunit
- Meiotically up-regulated gene 80 protein
- mRNA stability protein mug134
Sequence:
MKHIKNEREEVFLEDDQAQHSQAELLSSKDENLQPSIPLSPVAFELDFSGNFQFISDNSSELLDIPKDKIIGHSVAEVLGTDGYNAFMRAVNCLLKDDSHSYHVRFQHSINANHANQNYYTAKGDLPSDEKITKPFDAIGILIRHPGSAIPAHTMWVVNPATNSLGSVSPLVTKLLDVIGFGASLLDKYLCDLRTSYHKHNSLDALPLPTPEFCQICEREIQSWFFELHSKFCLSTSTYESVVQAAQDSLLYFRSTLLEIQEGMQKDSSLVPVYKNEPLIVDADDYFFTDENKQTLSLCSFLSQVMYYLEVAIDITIPPVKIIVNFDKVDSLRVQSPRSEKATIELDNYNPSLENCSSAVIALWEDIKTAVDTKITGVLRLRNAIYYSERIRLEIDHHVQEIIDDVVSNLVTNHSSTSLGHLESKLAPSITFPDACDALEAEECITRPGSATNTPQSDRSLDINDLSRSSSYSRHLSHVSLSNPDFAIGSPMSQDSSNYSSPLHRRKASDSNFSDPRFDDLKYLSPNSSPRFVASDGPNRPASNGRSSLFSRGRASNLGDVGLRLPSPSPRIHTIVPNSAPEHPSINDYKILKPISKGAFGSVYLAQKRTTGDYFAIKILKKSNMIAKNQVINVRAERAILMSQGESPFVAKLYYTFQSKDYLYLVMEYLNGGDCGSLLKTMGVLDLDWIRTYIAETVLCLGDLHDRGIIHRDIKPENLLISQNGHLKLTDFGLSRVGYMKRHRRKQSSSIPVLDLRDRSSAISDLSLSTASSVLEAQSLITPERPKRPSLNEKLLSLDGTSIRLAGQSFNYENSAEDSPTATNTPTSQVDESNIFRSTDSPRVQPFFENKDPSKRFIGTPDYIAPEVILGNPGIKASDWWSLGCVVFEFLFGYPPFNAETPDQVFQNILARRINWPAEVFTAESSVALDLIDRLLCMNPANRLGANGVEEIKAHPFFKSVNWDTILEEDPPFVPKPFSPEDTVYFDSRGLKGFDFSEYYNQPTVTEAQKLEEERPASSIPQHVSGNRKGRLRSNTISTPEFGSFTYRNLDFLNKANRNTIQKLRKEHMAVKSAKTSVDDTFSQYMSRFKAKLSTSQSVGPVKSSRRASMADYEASTTTRVQDITTDSIDSIDDFDSLKEGRMLSFFDNLALEDHKGVSSTMSASQSQSSMHTALPDVTEGTSSDEHTTIQKGRIDNLQAQSLTHKRNAISYPGLFQLDRLQMIIPKDEIELAEILKKIFPKLTLVLIDDPWSILKKLLQNEQFNVVFLHFGNDKVSSSRLMYSVRTSATINSRVPFVYICEDETCIPTDLQSDGVLLKPITCENIESCLRKLDVWHS
Protein: Paired box protein Pax-9 (Q2L4T1)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLAQQGHYDSYKQHQPTPQPALPYNHIYSYPSPITAAAAKVPTPPGVPAIPGSVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLGRNNFPAAAPHAVNGLEKGALEQEAKYGQAPNGLPAVGSFVSASSMAPYPTPAQVSPYMTYSAAPSGYVAGHGWQHAGGTSLSPHNCDIPASLAFKGMQAAREGSHSVTASAL
Protein: Calcium and integrin-binding family member 2 (Kinase-interacting protein 2) (KIP 2) (O75838)
Organism: Homo sapiens (Human)
Function: Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis (By similarity). Acts as a auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells (By similarity). Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing (By similarity). Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells (By similarity). Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). Critical for proper photoreceptor cell maintenance and function (By similarity). Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Z309}. Cell projection, stereocilium {ECO:0000269|PubMed:26173970, ECO:0000269|PubMed:26426422}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9Z309}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9Z309}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q9Z309}. Note=Colocalizes with ITGA7 at the myotendinous junctions (MTJ) and at the neuromuscular junctions (NMJ) (By similarity). Located mainly in stereocilia and at the apical surface of hair cells of the cochlea (By similarity). Localizes in the cuticular plate along and at the tip of the stereocilia of vestibular sensory hair cells (PubMed:26173970, PubMed:26426422). {ECO:0000250|UniProtKB:Q9Z309, ECO:0000269|PubMed:26173970, ECO:0000269|PubMed:26426422}.
Interaction partners:
- LHFPL tetraspan subfamily member 5 protein
- Transmembrane channel-like protein 1
- Transmembrane channel-like protein 2
- Transmembrane inner ear expressed protein
- Protocadherin-15
- Unconventional myosin-VIIa
- Whirlin
- Cadherin-23
- pre-mRNA splicing regulator USH1G
- Harmonin
Sequence:
MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI
Protein: Neuropeptide CCHamide-1 receptor (A1ZAX0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Receptor for the neuropeptide CCHamide-1. Plays a role in the modulation of starvation-induced olfactory behavior where starved flies show increased responsiveness to food odorants, repellants and pheromones.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neuropeptide CCHamide-2 receptor
- Neuropeptide CCHamide-1
Sequence:
MIANLVSMETDLAMNIGLDTSGEAPTALPPMPNVTETLWDLAMVVSQSTQWPLLDTGSSENFSELVTTETPYVPYGRRPETYIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAILCGLPALIGSNLKHLGINEKSIVICYPYPEEWGINYAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAVRQVRARRKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPTAQDDYNAFWHVLRIVAYCMSFANSCANPVALYFVSGAFRKHFNRYLFCRGASGRRKKRGQHDTFCMHRDTSLTSTASKRFQSRHSCYQSTIRSCRLQETTITTLPNGGNQNGANISAVELALPVLQAPGHNEAHAPPSYGFLPLNEIVQQTRSSPAKFQESLLN
Protein: Glutathione S-transferase U19 (AtGSTU19) (EC 2.5.1.18) (GST class-tau member 19) (Glutathione S-transferase 8) (Q9ZRW8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the glutathionylation of 12-oxophytodienoate (OPDA). In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC), and glutathione peroxidase activity toward cumene hydroperoxide.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:19174456}.
Interaction partners:
- Glutathione S-transferase F2
- Glutathione S-transferase F8, chloroplastic
- Glutathione S-transferase DHAR2
- Glutathione S-transferase F7
- Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial
- Glutathione S-transferase Z1
- Glutathione S-transferase DHAR1, mitochondrial
- Probable glutathione peroxidase 3, mitochondrial
- Probable glutathione peroxidase 8
- Probable glutathione peroxidase 2
Sequence:
MANEVILLDFWPSMFGMRTRIALREKGVEFEYREEDLRNKSPLLLQMNPIHKKIPVLIHNGKPVNESIIQVQYIDEVWSHKNPILPSDPYLRAQARFWADFIDKKLYDAQRKVWATKGEEQEAGKKDFIEILKTLESELGDKPYFSGDDFGYVDIALIGFYTWFPAYEKFANFSIESEVPKLIAWVKKCLQRESVAKSLPDPEKVTEFVSELRKKFVPE
Protein: Putative purine permease 12 (AtPUP12) (Q9FLL4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Nucleobase-ascorbate transporter 5
- Putative nucleobase-ascorbate transporter 9
- Nucleobase-ascorbate transporter 6
- Adenine/guanine permease AZG1
- Purine-uracil permease NCS1
- Adenine/guanine permease AZG2
- Ethylene-responsive transcription factor ERF069
Sequence:
MLLLKEEDEGRRRTSVPTQLMKLNRSQWWILVFISIFFLISAQAISVLLGRFYYNEGGNSKWISTLVQTGGFPILYLPLSLLPASQSSSSSSSSSSFKTLVWIYLSLGFAIGLDNFLYSVGLLYLSASTYSILCASQLAFNGVFYYYINSQKITCLIFFSVLFLSISAVLVSLDDDSNSPSGDSKWSYLIGCFCAVFASLIYSLQLSLMQFSFEKVLKSETLSMVLEMQIYTSLVASCVAVIGLFASGEWMLLSVEMEEFQEGQVIYVLTLVGAAVSCQLGCVGAVSLIFLVSSLFSNLISTLSLIVTPLAAIAVFHDKLTEVKMVAMPIAFTGFTFYIYQNYLDDLKVQRAREAQAE
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F1QEF3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Dual specificity protein phosphatase
- Zinc finger RNA-binding protein 2.
Sequence:
MAATKSGYEGKIAGLYDLDRTLGKGHFAVVKLARHVFTGQLVAVKVIDKTKLDDLATGHLLQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGGDMYDYILRHEGGVAEDTAKVHFAQIVRAIAYCHRLHVVHRDLKPENVVFFRQQGTVKLTDFGFSNHFKPGTMLMTSCGSLAYSAPEILLGEEYDAPAVDIWSLGVILYMLVCGHPPFQETNDSETLIMIMDCRYTVPNHISAQCKDLISRMLQRDPAKRASLAEIESHPWLQGVDPSPAGFTAAPLTSHRSLLPEEHEFILQAMTSGSIAGRDAIQEALEADRYNHITATYYLLGERLLRDKQEQSSLTPEQRNTQRPISEPLDLVSQVPRTDTLRGTPLSALAPLGSLSTGYVRRGVSESGDLLAPKANRHDNSFSDFCSTAPCLSLNMRPLPPDQPTVKSLGALQQICEEEEEEDEVKVKMAPGKLGPLPSTDLSLKPSTTSLQSEPQMRTGRHSSKGMGNCETLAEEEEELEEGSESIEEHKKPLDLVSSIPSGTVEHQVEMPPKTEPQVEEFKHTKQPGKGNDKSVFTHVSLSLEEQEGEEIQGPNVDGPIPAPRLDVVQCCWGQREPSKDILENNNNTLAKSRLLEAGVISTPCGSPRSLPRNHCVDLGPDGVEMRKTVGELEKPEEVQPKSQKVLQGTRGTITDPTIRADPSKVKNVNLRERLMQFPLCEKALSFNIQPTSKEKLLPFAQYNCCHVL
Protein: Tubulin beta 4A class IVa (M0QYM7)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEGEFEEEAEEEVA
Protein: Candida glabrata strain CBS138 chromosome F complete sequence (Q6FUJ6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- 60S acidic ribosomal protein P0
- L21
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS5
- Candida glabrata strain CBS138 chromosome M complete sequence
- 60S ribosomal protein L36
- L23
- Small ribosomal subunit protein eS6
- 40S ribosomal protein S8
- Small ribosomal subunit protein eS21
Sequence:
MPPKFDPNEVKYLYLRAVGGEVGASAALAPKIGPLGLSPKKVGEDIAKATKDFKGIKVTVQLKIQNRQATASVVPSASSLVITALKEPPRDRKKDKNVKHSGNVALDEIIEIARQMKEKSFGKNLASVTKEILGTAQSVGCRVDFKNPHDIIEAINAGEIEIPEN
Protein: Bacterial non-heme ferritin-like protein (P0A9A2)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MATAGMLLKLNSQMNREFYASNLYLHLSNWCSEQSLNGTATFLRAQAQSNVTQMMRMFNFMKSVGATPIVKAIDVPGEKLNSLEELFQKTMEEYEQRSSTLAQLADEAKELNDDSTVNFLRDLEKEQQHDGLLLQTILDEVRSAKLAGMCPVQTDQHVLNVVSHQLH
Protein: E3 ubiquitin-protein ligase TRIM34 (EC 2.3.2.27) (Interferon-responsive finger protein 1) (RING finger protein 21) (Q9BYJ4)
Organism: Homo sapiens (Human)
Function: Functions as antiviral protein and contributes to the defense against retroviral infections. Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis. Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:31487507, ECO:0000269|PubMed:32282853}. Mitochondrion {ECO:0000269|PubMed:31956709}. Note=Localizes in cytoplasmic bodies together with TRIM5 and incoming HIV-1 capsids during infection. {ECO:0000269|PubMed:32282853}.
Interaction partners:
- T-cell receptor-associated transmembrane adapter 1
- Gamma-butyrobetaine dioxygenase
- Tripartite motif-containing protein 5
Sequence:
MASKILLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSFEHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVRCYWVDVTLNSVNLNLNLVLSEDQRQVISVPIWPFQCYNYGVLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYPYFNPWNCPAPMTLCPPSS
Protein: Androgen-dependent TFPI-regulating protein (Fatty acid esters of hydroxy fatty acids hydrolase ADTRP) (FAHFA hydrolase ADTRP) (EC 3.1.-.-) (Q96IZ2)
Organism: Homo sapiens (Human)
Function: Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).
Subcellular location: Cell membrane {ECO:0000269|PubMed:21868574, ECO:0000269|PubMed:27018888}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with TFPI and CAV1 in lipid rafts. {ECO:0000269|PubMed:21868574}.
Interaction partners:
Sequence:
MTKTSTCIYHFLVLSWYTFLNYYISQEGKDEVKPKILANGARWKYMTLLNLLLQTIFYGVTCLDDVLKRTKGGKDIKFLTAFRDLLFTTLAFPVSTFVFLAFWILFLYNRDLIYPKVLDTVIPVWLNHAMHTFIFPITLAEVVLRPHSYPSKKTGLTLLAAASIAYISRILWLYFETGTWVYPVFAKLSLLGLAAFFSLSYVFIASIYLLGEKLNHWKWGDMRQPRKKRK
Protein: Lysozyme C-1 (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C) (P00697)
Organism: Rattus norvegicus (Rat)
Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. In the intestine they may also have a digestive function.
Subcellular location: Secreted.
Interaction partners:
- Lysozyme d1
- Lysozyme f1
Sequence:
MKALLVLGFLLLSASVQAKIYERCQFARTLKRNGMSGYYGVSLADWVCLAQHESNYNTQARNYNPGDQSTDYGIFQINSRYWCNDGKTPRAKNACGIPCSALLQDDITQAIQCAKRVVRDPQGIRAWVAWQRHCKNRDLSGYIRNCGV
Protein: Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1) (Q68D10)
Organism: Homo sapiens (Human)
Function: Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4. Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:E1BUG7}.
Interaction partners:
- Histone H4
- Histone H3.2
Sequence:
MDFREILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR
Protein: Style cell-cycle inhibitor 1 (AtSCI1) (Q8GWY0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the auxin signaling transduction pathway that regulates cell proliferation and differentiation during flowers stigmas and styles development. Involved in the regulation of auxin-related genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:25443839}. Note=Inside the nucleus, confined to the interchromatic region. {ECO:0000250|UniProtKB:A0A1S4AX27}.
Interaction partners:
- Phototropic-responsive NPH3 family protein NPY1
- Reticulon-like protein B8
- Reticulon-like protein B11
- Clathrin light chain 3
- Reticulon-like protein B3
- Cytochrome P450 71B6
- Probable pectinesterase 48
- Protein TRANSPARENT TESTA 9
- Conserved oligomeric Golgi complex subunit 6
Sequence:
MVSERSSKEKKRSRARSEDSSSSDYEEKVKRHRGTEKDDERRSRRSDKKDKKSHKHHKSSTSKKSKDDKPKKKHTESDHKLKEGIPELSMEDYFSKNNEFATWLKEEKRTYFNDLTTEAARGLFSRFVKRWNRGKLESRYYEGISTAPRTAHDWMIKRR
Protein: Uncharacterized protein (Q57WE0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQTPLTDEERKAKEARLRELRSELEGRGHPSTASAGAQQHEQQEDVPGYDEGSECSNDSDEDFFTGAENAAGVCMFAEPMEEPLGHTLETSPCVRRGIVGDFELLRLAKMGDLVSFREFAALTSADPTTFRDNHGRNAMHYAADSGNIALLQHLIDSNVPFTTDEKKMTPVDIATLNQYNDVVKLLAETFPQAADLVKSYEEVLELFAVPPPRFTMTKPAPPIEENSRPRAFWKAERTASATASADITVSQLTDAHHSLILRGLSGLELAQEGHGFHSWLPPAEPAVTAAVLPRAKVVGALRKPNNGDGKEEDISGLVMAVPLGGSVALKSGGARIENPFLITQLALHPALRGANRTPLLLEEMHKLLLSSGATTAVFRSYLQLPIPAVGLVKWSRRSIAPGHVFKRRYATEVFPDFFQYDDVLRADIITKNALTKSFCDNAGRCARWELVDRKNTEQLHHLHSFITSQAETLFDVAYLTQSVDDLLTSIVGEGLSSFVHRPSTGGGITDVVVLRLRPGGAGKGESQELNPLAAVCVYAMFSSLKGPAKAEEVLALAYSLKAETVFIPNMFGFLDSDLSKAMFEELLHLREYLYMPRAVTDAAVRATAMSKVAIPCFFI
Protein: Probable inactive serine protease 37 (Probable inactive trypsin-X2) (A4D1T9)
Organism: Homo sapiens (Human)
Function: Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:27649891}. Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MKYVFYLGVLAGTFFFADSSVQKEDPAPYLVYLKSHFNPCVGVLIKPSWVLAPAHCYLPNLKVMLGNFKSRVRDGTEQTINPIQIVRYWNYSHSAPQDDLMLIKLAKPAMLNPKVQPLTLATTNVRPGTVCLLSGLDWSQENSGRHPDLRQNLEAPVMSDRECQKTEQGKSHRNSLCVKFVKVFSRIFGEVAVATVICKDKLQGIEVGHFMGGDVGIYTNVYKYVSWIENTAKDK
Protein: Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] (Q9Z110)
Organism: Mus musculus (Mouse)
Function: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:39506109}. Note=Exhibits puncta-like structures inside mitochondria under nutrient stress (By similarity). When cellular dependence on oxidative phosphorylation increases, forms filaments, which may increase its activity, and is sequestered in a subset of atypical mitochondria that lack cristae and ATP synthase (PubMed:39506109). {ECO:0000250|UniProtKB:P54886, ECO:0000269|PubMed:39506109}.
Interaction partners:
- Ornithine aminotransferase, mitochondrial
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Pyrroline-5-carboxylate reductase 1, mitochondrial
- Pyrroline-5-carboxylate reductase 3
- Pyrroline-5-carboxylate reductase 2
- Glutamine synthetase
- Glutamate dehydrogenase 1, mitochondrial
- Glutamate decarboxylase 1
- Glutamate decarboxylase 2
- Glutaminase kidney isoform, mitochondrial
Sequence:
MLRHMHRSGVQPFRQRLLPWVQSIAVPRSNRVQPSAIRHVRSWSNIPFITVPLSRAHGKPFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNHLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGLGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIINHLADLLTDQREEILLANKKDLEEAEGRLASPLLKRLSLSTSKLNSLAIGLRQIAASSQESVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAIQLVNTREEVEDLCRLDKIIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLEVCIEVVDSVQEAIDHIHKYGSSHTDVIVTENEKTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGQDHVVSDFSEHGSLKYLHENLPVPQRNFS