wanglab/gogpt-training-data huggingface dataset:
Protein: Ion channel DMI1 (Does not make infections protein 1) (Q6RHR6)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Required for early signal transduction events leading to endosymbiosis. Acts early in a signal transduction chain leading from the perception of Nod factor to the activation of calcium spiking. Also involved in mycorrhizal symbiosis. May be involved in the regulation of the calcium channel responsible for calcium spiking by mobilizing another cation, and thereby altering the membrane potential.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:17173544, ECO:0000269|PubMed:27230377}; Multi-pass membrane protein {ECO:0000269|PubMed:17173544}.
Interaction partners:
Sequence:
MAKSNEESSNLNVMNKPPLKKTKTLPSLNLRVSVTPPNPNDNNGIGGTSTTKTDFSEQQWNYPSFLGIGSTSRKRRQPPPPPSKPPVNLIPPHPRPLSVNDHNKTTSSLLPQPSSSSITKQQQQHSTSSPIFYLLVICCIILVPYSAYLQYKLAKLKDMKLQLCGQIDFCSRNGKTSIQEEVDDDDNADSRTIALYIVLFTLILPFVLYKYLDYLPQIINFLRRTESNKEDVPLKKRVAYMVDVFFSIYPYAKLLALLCATLFLIAFGGLALYAVTGGSMAEALWHSWTYVADAGNHAETEGTGQRIVSVSISAGGMLIFAMMLGLVSDAISEKVDSLRKGKSEVIERNHVLILGWSDKLGSLLKQLAIANKSVGGGVIVVLAEKEKEEMEMDIAKLEFDFMGTSVICRSGSPLILADLKKVSVSKARAIIVLAADENADQSDARALRVVLSLAGVKEGLRGHVVVEMSDLDNEPLVKLVGGELIETVVAHDVIGRLMIQCALQPGLAQIWEDILGFENAEFYIKRWPELDDLLFKDILISFPDAIPCGVKVAADGGKIVINPDDNYVLRDGDEVLVIAEDDDTYAPGPLPEVRKGYFPRIRDPPKYPEKILFCGWRRDIDDMIMVLEAFLAPGSELWMFNEVPEKERERKLAAGELDVFGLENIKLVHREGNAVIRRHLESLPLETFDSILILADESVEDSVAHSDSRSLATLLLIRDIQSRRLPYRDTKSTSLRLSGFSHNSWIREMQQASDKSIIISEILDSRTRNLVSVSRISDYVLSNELVSMALAMVAEDKQINRVLEELFAEEGNEMCIKPAEFYLFDQEELCFYDIMIRGRTRKEIVIGYRLANQERAIINPSEKSVPRKWSLDDVFVVLASGE
Protein: PE family immunomodulator PE35 (P9WIG7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PPE68, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2).
Subcellular location: Secreted {ECO:0000269|PubMed:17443846}. Cell surface {ECO:0000269|PubMed:24467650}.
Interaction partners:
- PPE family immunomodulator PPE68
- ESAT-6-like protein EsxB
- ESX-1 secretion system protein EccCb1
- 6 kDa early secretory antigenic target
- ESX-1 secretion system protein EccD1
- ESX-1 secretion-associated protein EspJ
- ESX-1 secretion-associated protein EspI
Sequence:
MEKMSHDPIAADIGTQVSDNALHGVTAGSTALTSVTGLVPAGADEVSAQAATAFTSEGIQLLASNASAQDQLHRAGEAVQDVARTYSQIDDGAAGVFAE
Protein: Polyamine transporter TPO5 (P36029)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for polyamine transport. Transports putrescine effectively and spermidine less effectively.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:15668236}; Multi-pass membrane protein {ECO:0000269|PubMed:15668236}.
Interaction partners:
- Urea active transporter
- Polyamine transporter 1
Sequence:
MPEYTLLADNIRENIVHFDPNGLFDNLHTIVHEDDSQENEEAEHFNYDQVLDKSLLSRGSIVGLGLGLMSPVLGMCTSMAIGLINGGPLTIMLGFLISGVCIWFSSLSLGEIVSKFPMELHVGSAMLAPEKLKLVCSWYTGWLMLIGNWTMSTSITFAGAQLTISLILMTNSNLISEAHLIFYTVIVFYLVVTVVGLVNLKFARFIETINKVCVYWIIYAIIFIDILLLVFHKGKFRSLKYALFHFDNNLSGYKSAFLSFIIGFQQSNFTLQGFSMLPALADEVKVPEKDIPRGMSNAVLLSAFSGVIFLIPIMLILPDNDLLFTNHKVLPIVNIFTKSTDSVVLSFFLVLLILGNLLFSGIGSITTSSRAVYSFSRDQAIPYYDKWTYVEPDSQSKVPKNSVVLSMIISYFLGLLALISTAAFNAFIGAAVLCLCSATFIPLVLVLFTRRRAIRSAPVKIRYKFGWFINIVSIVWLLLSMVSVCLPTQVPVTFKTMNYALMVYVFCILVITGLYFKWGKYNFRLPLADDIKAPIPSDAEETVFELEDSNVEHTLNSGTTVKESVENNSEEGFIKVHPKSSTENPFEENEENVITDYGDEHHTAEQEFDLADDRRYDI
Protein: Meiotically up-regulated gene 62 protein (Q09773)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative acyl carrier protein, mitochondrial
- Tubulin alpha-1 chain
Sequence:
MSLKSFFNFNKKTKLHDIEEDVISEIGSAGSALRTDAHMLKANDVYYKSETDSHTVLRFMKPSENEKIHPVRHSKYEDKSKLPFETIPDPVLKYVKRARDAELQPQLAKVSQKLFADISTATAAEKLQFTVPRRARFEINDPRNPTFSMMALQDIISVLEYRRNKNPTSTAHICIDKKGKEAVSYSWDKILNRAKQFASVAQNHVGLKPGTRVILYYRKSEASEYIISIFGCLLLGIVVIPLSPSSSSESLKLVVNEEKVRVAFTTEATYRIFIKDTEVNNAKSLAWWKSNDFTNYKFEQIKQYRMRANDTVLIDYTFSSSTYNDIKAVYTTKTFLSQMRNLTSSMITNPARQAGWKLHNFEDSKDVLITNFHPSMPLGLIMGVFNSVFAGYCTIFCDEEVLKTPGLLAYLITKYRCTYSLFDYAGLKQTVYNYQEDPKSTLSFKKNYTPNLSSLKLCMVECEVVDPEFNIIVSDRWLQPLGTNNSKEVITPILCLRKFGGIPISFKDWMISYTNRQKHERQMADTCYQEILVLKSSIEKEKVEIVPFLDIRKYSPNEVLCMSPFWYPIPEASVAVVNEDSKNICKVGEVGEIWVYSDCLPKLKAASVINNPQGEQLTDYENNQENKFEKNNSFMDSGLKGFLHNEKIFVLGNKDEQIRQYRKTMVADKLMEEKYVHYSHYLIKKIMKYVPEIFDGVAFEIEIDKAVYSVLVLESPIIKRSLIRNNRLKGRDLFSELVKITESSFQVTQDIFKLDVLSILIAPYKSLPRSRYMGIQAINTNKCKLAFLSGNLPVSYVRFFMDSALPKSKINLNNSKGIWSKDASKHHREIISLNVKQKMDPYKHQNKVSKARENLLNHFTILDFLKTKSAKTPTSPAILTFNAIEKTKVELTWAHFELKVASHVEYMQLSVKAKARSHILLLYYDPLEFLISIHSCFHLGVIPIPFQIREISQLIGEIEEFTKIAKAFNVEAILVDHKVLISLKSRDISNHFQQTCIDLNMKAPKIFETTGIPISKRAKKALNLITPGELNNKGKVALISINKLEDGSIIPTQFSHSSLLAFCHEQKEFVIGNEEKPIIGGIEFSSGMGLLHTALLGVYAGVPTLLIKQENLCNNGSLLFEAIEQNSLSKVMIPLNICQKSFSTAQGCNSIVINSTLSSIIVPCYDRPISSRVNSIIEDIARIGLAPNKVKLAYSHPINPFVCWNADSSMEKMKDYFDANQLRSGLVNVREDVLRNRQPLLYGSGTSTLYNEICIVHPEEKYICQEGEIGEIWINGKHGSYCENNELNSGCELLVQETLDKKSYSRTGQLGFIHHLKKKDQNMEKVPVLYTLDFIWNTLELNGLNHSVKDIEETIELVHPNICTDGCILFQASGSVVILLEVHSQQKFASLIPIIVATALAAHEIILDCVAFVPKGTFLRRPTGEKRRADILKQWTGGDLKHMTSYLIRQDFLLNEDFVGTELIGTTDSYDYSDENLIINSSQLNLL
Protein: Doublecortin domain-containing protein 2C (A8MYV0)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:28395323}. Cytoplasm {ECO:0000269|PubMed:28395323}. Note=Detected along the length of the sperm flagellum and in the cytoplasm of the germ cells. {ECO:0000269|PubMed:28395323}.
Interaction partners:
Sequence:
MGTRGPSAPVDTTPAKTIVVYRNGDPFYVGKKFVLSRRRAATFEALLEQLTEQVDVPFGVRRLFTPTRGHRVLGLDALQAGGKYVAAGRERFKELDYIHIVPRKPAKIRKLKEIKPVVHCDINVPSKWQTYHRISRHINVFTNGRLFIPPAKIIIPKFSLSDWDIVLATIGEKVFPLGGVRKLFTMNGHLLGDSKDLQDNHFYVAVGLETFKYFPYWKSPRVPSEVQQRYANVEKNSQRKKKVDSKGKEPCKYDGIPPKTQDSVYYAKEEKKKTLAEPLVQRGAEGDVYKAPTPSKETQGALDVKEEHNVQLEVPVDQRQAEIVKEDEEIHENTPDFEGNKDKEDARLCEDVERKMAREWKPVD
Protein: tRNA splicing endonuclease subunit 15, isoform A (EC 4.6.1.16) (A1Z7S9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- tRNA-splicing endonuclease subunit Sen34
- tRNA splicing endonuclease subunit 54
- tRNA-intron lyase
Sequence:
MVRQYPIAGCSQTVMYSLDFQLELNDFTTVSPDDLTAALGFQIYNDLKNGNSSIFNSQFNIYYYALEEESAEFQPNYDPNLKVFYLMKNDDVYIPVLHTKAIDFRIVKSLHKKLKKRCVLNVMKIIFMFLTTLFPISNIFLAVVDNTANILYYQMSEGLSENQSTKTAVK
Protein: Flocculation protein FLO11 (Flo11p) (Flocculin-11) (ClFLO11) (C4XZ24)
Organism: Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Function: Homophilic binding protein that enables kin discrimination in heterogeneous yeast populations by mediating homotypic cell-cell interactions during flocculation, a reversible and asexual process in which cells adhere to form aggregates (flocs).
Interaction partners:
Sequence:
MLRGFFTLLIFVAFTAATAVINACPNQKFTFHAQVVNFPQATITVTDPSDNGDGTWDVTINFNADATMSLKSLSELKILSLSKTYFLYSYNLKVDNINNPGSWSQRVTVTPRSVGDYKTCMPQFTIQYDWCSAGVTDWSECQNWKYQGSYDYITGCDNFDQSTGFSQKDAPDYCWDATLPQSSSAVISSAAPSSSAPVVPSAPATPNTPSSPSDPNTINACPNQKFTFHAQVVNFPQATITVTDPSDNGDGTWDVTINFNAVATMSLKSLSELKILSLSKTYFLYSYNLKVDNINNPGSWSQRVTVTPRSVGNYKTCMPQFTIQFDWCSAGVTDQSECQNWKYQGSYDYITGCDNFDQSTGFSQKDAPDYCWDVNVPSSSSAIVSSSAAPSSSSVPAAPSSSSVPVAPQSSSAPAVPSAPATPNTPTDPDTINACPNQKFTFHAQVVNFPQATITVTDPSDNGDGTWDVTINFNAVATMSLKSLSELKILSLSKTYFLYSYNLKVDNINNPGSWSQRVTVTPRSVGNYKTCMPQFTIQYDWCSAGVTDWSECQNWKYQGSYDYITGCDNFDQSTGFSQKDAPDYCWNEPKSSSSQSSATYLTPHNFDVTSGDFSVPASSSVVSSQASSSVVSSQASSSVVSSSSSEVTSETPNDPQNRPPPRTVGPEVSTVTFSSDSASSAISSRTARLSSSAASSGLSSSEVSSSEVSSTLPSSDASSTEASSVVSSDASSAITSEFHPHTLAPKFSLVSSYDFPPSSDSISTESSSQESSVVSSTDGSSVVSSTEVSSKASSTDGSSAISSTEESSKVSSTDVSSSTEESSVVSSTEASSKVSSTEGSSVVSSTEVSSKASSKISSRASSTEGSSKVSSTEVSSKVSSAEVSSTEVSSKVSSTEGSSAVSSTEGSSVVSSDVSSKVSSTEVSSRASSKVSSKVSSTEESSKVSSTEVSSKVSSTDGSSVVSSTEVSSKDSSSTTSEFHPHTLAPKFSLISSYDFPPSSDSISTESSSQESSVVSSTDGSSVVSSTHGSSIVSSTEVSSKVSSTEGSSVVSSTEASSKVSSTEVSSKASSKTSSRVSSTEGSSVVSSTEVSSTASSSTTSEFHPHTLAPKFSLISSYDFPPSSDSISTESSSQESSVVSSTEGSSKVSSKVSSTDGSSVVSSTEGSSKVSSTEASSKASSTEGSSKVSSTEASSKASSTEGSSKVSSTEASSKVSSTKASSKVSSSKVSSTEASVVSSTEGSSKVSSTERSSKVSSTDASSVVSSTDGSSVVVSSTETSSVAYPTDSSSVVSSTEASATTSEFHPHTIAPKFSLITSDEVSSTDGSSVVSSTEGSSKVSSTEGSSKASSTEGSSKVSSTEGSSKASSTEGSSVVSSTEGSSKVSSTEASSKVSSTKVSSTEASVVSSTEGSSKVSSTEASVVSSTEASSVVSSTEASSVASSTEGSSVVSSTEGSSVVSSTEASSVASSTEGSSVVSSTEGSSVVSSTEASSVVSSTEGSSVVSSTEGSSKVSSTEASSVASSTEGSSVVSSTEASSVVSSTDDSSIVSSTETTSTWPHTIAPKFSLVTSSEPSTEQSSVASSTETSNSFTTTFPVDPRILIESSTSSTIFSSSETPISSFARYTNSSIVVSTPQPSEPAFSLPPPGQPVVPAFSSGSSFDASSSTNVDSSSASPSGSFSTDSSSGSLFVSSSDLTSSSTFSSASSTIASSGSSPSPSVPGYSSTDGSSSGVPSGSIPAVPFGASSTDGSSYSVPSGSSPAVPSGSSSTDGSSYSVPSGSSPAVPSGSSSTDGFSSVASESSPADPTGSQYATTSVPSASVTSDVSTSGFTSEQPTPSAPGTTTLTITSCDKSTCTTSYKTTGITVRTTTIGSLVTKFTTYCPLTGVSSTPSPSEGVQTPTTGSPDVPSPSTTTITETTCDETSCTTSYKTTGVTVITTTVGSIVTKYTTYCPLTGTSPSEPLNGVSTGVPHVPAPSTTTITEVSCDDTTCATAYKTTGLTVVTTTIGSVVTEYTTYCPLSGTHSEVVETVSTIAPTASAPSTTTITETSCDESSCTTAYKTTGVTVITTTINEMVTEYTTYCPLSGQSTATTPVGETSTTPAGSKETTISSVYHSGSPVSTESGVVSSPSSSPLITIASTSGGASNVRLSVASLLVLLPLFI
Protein: Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) (EC 3.6.1.5) (ATP diphosphohydrolase) (ATP-DPH) (ATPDase) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) (NTPDase1) (CD antigen CD39) (P55772)
Organism: Mus musculus (Mouse)
Function: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Subcellular location: Membrane {ECO:0000250|UniProtKB:P49961}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P49961}. Membrane, caveola {ECO:0000250|UniProtKB:P49961}.
Interaction partners:
- 5'-nucleotidase
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleoside triphosphate diphosphohydrolase 6
- Ectonucleoside triphosphate diphosphohydrolase 5
- Cancer-related nucleoside-triphosphatase homolog
- AMP deaminase 2
- Ectonucleoside triphosphate diphosphohydrolase 2
- AMP deaminase 3
Sequence:
MEDIKDSKVKRFCSKNILIILGFTSILAVIALIAVGLTQNKPLPENVKYGIVLDAGSSHTNLYIYKWPAEKENDTGVVQQLEECQVKGPGISKYAQKTDEIGAYLAECMELSTELIPTSKHHQTPVYLGATAGMRLLRMESEQSADEVLAAVSTSLKSYPFDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLSLISDSQKQETFGALDLGGASTQITFVPQNSTIESPENSLQFRLYGEDYTVYTHSFLCYGKDQALWQKLAKDIQVSSGGVLKDPCFNPGYEKVVNVSELYGTPCTKRFEKKLPFDQFRIQGTGDYEQCHQSILELFNNSHCPYSQCAFNGVFLPPLHGSFGAFSAFYFVMDFFKKVAKNSVISQEKMTEITKNFCSKSWEETKTSYPSVKEKYLSEYCFSGAYILSLLQGYNFTDSSWEQIHFMGKIKDSNAGWTLGYMLNLTNMIPAEQPLSPPLPHSTYIGLMVLFSLLLVAVAITGLFIYSKPSYFWKEAV
Protein: Dual specificity mitogen-activated protein kinase kinase sek-1 (MAP kinase kinase sek-1) (EC 2.7.12.2) (G5EDF7)
Organism: Caenorhabditis elegans
Function: Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacterial and fungal infection. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2. Probably by promoting pmk-1-mediated activation of skn-1, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacterial infection. Probably downstream of tir-1, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. Regulates susceptibility of B.thuringiensis pore-forming toxin Cry5B and Cry21A. Involved in the response to oxidative stress. May regulate transcription factor daf-16 localization during oxidative stress. By phosphorylating pmk-1, regulates skn-1 localization during oxidative stress. By phosphorylating and activating pmk-1, plays a role in the stabilization of transcription factor rnt-1 in the intestine during oxidative stress. Up-regulates expression of gcs-1 in intestine upon arsenite treatment. Regulates germline proliferation in response to osmotic stress, starvation and germline apoptosis induced by heavy metals, such as Cu(2+). In association with mek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Plays a role downstream of tir-1/nsy-1 in regulating susceptibility to anoxia. In males, by regulating pqn-41 expression, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Involved in egg laying.
Interaction partners:
- Mitogen-activated protein kinase pmk-1
- Mitogen-activated protein kinase kinase kinase nsy-1
- Mitogen-activated protein kinase pmk-3
- Mitogen-activated protein kinase pmk-2
- Mitogen-activated protein kinase kinase kinase mom-4
- Mitogen-activated protein kinase kinase kinase
- Serine/threonine-protein kinase SULU
- Protein kinase domain-containing protein
- NAD
- Transcription factor atf-7
Sequence:
MERKGRERKLPGMKIVMPTPVETPTMNLEDRCLIKLTNESEEIEIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKIGKHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFMEQARNEKQFSMARFINEILDTVWRR
Protein: LD33470p (Pipsqueak, isoform B) (Pipsqueak, isoform C) (Q7K0T7)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00320}.
Interaction partners:
Sequence:
MAAVRGHQYFSLRWNNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHPTIILPADIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAEQLKIKGLCETAENADDLNDAATATITVSENIQQAVVGNIVNAAIVPGAPSPSLEQQQQHHQQQQQQQAQEQHQQQQVHAQQQQQQQQQINAALLTQHGVSSGSVSLSGQLLSSSASGSSGSLAGGQQASQTPSGLQPTPRKSRLKRSKSPDLSSGGGAGSSGGSSSGSTQQQPQPAHHHHPQTILIQGQNPNSIVSLQQTADGNYIPVSGSGDDSDAEDHEHEHNHGHGHGHGGHTHGHGHSHEHSHDHEHEHKPNKICKTEHSVASPASNSSSASNNAAGVSGVTSTGQAIVTQIVVARDGKDTKNMTSLGMGMNGGLLGVPMGFLDFTPEPPAPSATPVTVTEHVDLSCNPSTDTRDLSNTTEPLDIDNHLAQQIHRLDQSPMHSISHHHTGDESNSNLVQHIKSEVIEAKHLAAQHHALSQAQQQHAHHQAHQQHQQHQQQQHQQQQQHLHAQQLLAQSQLQQQQQQQQQQQQHHQQQQQQAAAAAAAAGVHGQHGGHVTHADIGGATVMEIDPSQIKHEPGMIITPEIVNMMSSGHMDMYNSDTSEDSMMIANGSPHDQKEPHYTNLDQQHGLGGSVCGPGPGGAGGGGGMSGGAGSGSGEKGQFNGPKAWTQDDMNSALDALKNQNMSLTKASAIYGIPSTTLWQRAHRMGIETPKKEGGTKSWNEDALQNALEALRSGQISANKASKAFGIPSSTLYKIARREGIRLAAPFNAAPTTWTPEDLERALEAIRAGNTSVQKASAEFGIPTGTLYGRCKREGIELSRSNPTPWSEDAMNEALNSVRVGQMSINQAAIHYNLPYSSLYGRFKRGKYDVVANTSGVALLNTSGNTTGSIEIIEHSQENSLHMLQQQFPYSPSPHPPTPQHHSTPQHHSSAQQGPPTPQHMQQHVVHMQQQQQQQQQQSPHPGHHPQHMQQDVVTSSSQVVHSQQQQQLQQIYQHHGTPERS
Protein: G-protein coupled estrogen receptor 1 (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (I3LSZ2)
Organism: Sus scrofa (Pig)
Subcellular location: Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine membrane {ECO:0000256|ARBA:ARBA00004332}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004332}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004439}. Early endosome {ECO:0000256|ARBA:ARBA00004412}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004653}. Golgi apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004225}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Recycling endosome {ECO:0000256|ARBA:ARBA00004172}.
Interaction partners:
- Estrogen receptor beta
- Tyrosine-protein kinase
- GNAS complex locus
- Focal adhesion kinase-related nonkinase
- Estrogen receptor
Sequence:
METQPGAFNGTPAAAAAGLGLDLPGALANRSAALSEHQQYVIGLFLSCVYTAVLFPIGFVGNLLILVVNIRFREKMTVPDLYFINLAAADLVLVADSLIEVFNLDEQYYDMAALCTFMALFLQVNMYSSVFFLTWMSFDRYLALAQALRCGPLRTKPRARLSCGLIWMASVSATLVPFTAVHLQHGEEACFCFADVREVQWLEVTLGFVVPFAIIGLCYSLIVRVLVTAHKHRGLRPRRHKALRMILAVVLVFFVCWLPENVFLSVHLLQRAPPGAGPCQQSLRHAHPLAGHVVNLAAFSNSCLNPLVYSFLGETFRDKLRLYLQQTASVSALSRFGHAALKAVVPDSTEASDGKVGSAV
Protein: Indian hedgehog protein (IHH) (EC 3.1.-.-) (HHG-2) [Cleaved into: Indian hedgehog protein N-product] (P97812)
Organism: Mus musculus (Mouse)
Function: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Plays a role in hedgehog paracrine signaling. Associated with the very-low-density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance (By similarity).
Subcellular location: [Indian hedgehog protein N-product]: Cell membrane {ECO:0000250|UniProtKB:Q14623}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The N-product remains associated with the cell surface. {ECO:0000250|UniProtKB:Q15465}.; SUBCELLULAR LOCATION: [Indian hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Secreted {ECO:0000250|UniProtKB:Q14623}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}.
Interaction partners:
- Protein patched homolog 1
- Protein patched homolog 2
- Protein smoothened
- Hedgehog-interacting protein
- Cell adhesion molecule-related/down-regulated by oncogenes
- Brother of CDO
- Growth arrest-specific protein 1
- Sonic hedgehog protein
- Runt-related transcription factor 2
- Parathyroid hormone-related protein
Sequence:
MSPAWLRPRLRFCLFLLLLLLVPAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLENGERVALSAVKPGDRVLAMGEDGTPTFSDVLIFLDREPNRLRAFQVIETQDPPRRLALTPAHLLFIADNHTEPAAHFRATFASHVQPGQYVLVSGVPGLQPARVAAVSTHVALGSYAPLTRHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFPSLAWGSWTPSEGVHWYPQMLYRLGRLLLEESTFHPLGMSGAGS
Protein: Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase) (P49247)
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate and participates in the first step of the non-oxidative branch of the pentose phosphate pathway.
Interaction partners:
- Transaldolase
- Ribulose-phosphate 3-epimerase
- Ribulose-phosphate 3-epimerase-like protein 1
- 6-phosphogluconate dehydrogenase, decarboxylating
- Transketolase
- Transketolase-like protein 2
- Transketolase-like protein 1
- Ribokinase
- Ribose-phosphate pyrophosphokinase 1
- Ribose-phosphate pyrophosphokinase 3
Sequence:
MQRPGPFSTLYGRVLAPLPGRAGGAASGGGGNSWDLPGSHVRLPGRAQSGTRGGAGNTSTSCGDSNSICPAPSTMSKAEEAKKLAGRAAVENHVRNNQVLGIGSGSTIVHAVQRIAERVKQENLNLVCIPTSFQARQLILQYGLTLSDLDRHPEIDLAIDGADEVDADLNLIKGGGGCLTQEKIVAGYASRFIVIADFRKDSKNLGDQWHKGIPIEVIPMAYVPVSRAVSQKFGGVVELRMAVNKAGPVVTDNGNFILDWKFDRVHKWSEVNTAIKMIPGVVDTGLFINMAERVYFGMQDGSVNMREKPFC
Protein: Tiger protein C1 (Loose aggregate C protein) (Loose aggregate C1 protein) (Transmembrane, IPT, Ig, E-set, Repeat protein C1) (P42523)
Organism: Dictyostelium discoideum (Social amoeba)
Function: tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. Could function as a non-diffusible cell-cell signaling molecule that is required for multicellular development. Has both cell-autonomous and non-cell-autonomous functions. Terminal node, epistatic both to comC and tgrD1. Activates tgrD1.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11071787, ECO:0000269|PubMed:15561583, ECO:0000269|PubMed:1577768, ECO:0000269|PubMed:498273, ECO:0000269|PubMed:7407916}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:11071787, ECO:0000269|PubMed:15561583, ECO:0000269|PubMed:1577768, ECO:0000269|PubMed:7407916}.
Interaction partners:
- Tiger protein B1
- Contact site A protein
- G-box-binding factor
- EGF-like domain-containing protein comC
- Mannosyltransferase
- Calcium-dependent cell adhesion molecule 1
Sequence:
MEKKIILLILFLFFISGYSMNPPTPIDAIYDDKSFTLIFNSNLPYSTRLILYKNEKEPRTEMAPNYFNCSLVDGERHCLFHSDEPFSRLWGSIDSKVCVRDKSNTVEDCTFDASGLVYYPKVYNLKYSKKPKTSGEDIVITGSYLRLFGGPNFLINSIDVNKPFVVKGNFSDPSFDCNNITVTFPPGSGKFRLYYDETGDNPVPFSYESPIISSSVSDSSKQIITINGDNFFTDKDLVKVSFDGIDQPNFIISVNHKQIQVNNYNRVDPGPMSVNITVDEVSIEKNYIHCFPAIITSISSVSNHLDGIVTIKGEKLSSTLNSSLTPSITIGDKVCKFIKSTTTELECKLDANELGGKNLPVNVNFGGCDSTSPNGVSFTYNIPTLSSGSYSNGIVTLIGTNLGTNNESSIQLYGDGIKNTNISQFNVSSSDEKSVTFELPHLRCRSFNINFTRSGITAKTLSISASLSVNVINRPTVSNGILNIEIYYMDCTISSSAPSITVGDSSSASPCSIPSSNSSYYETTCPTPYGTGINKQFIFKLNSETVSDQFSYAPPEVENRTISDDGTNIELHGNNFGNSTSLIKVYLNGSDISSEIQELEDHQLTIKILDSYENGPINITVDGNYMDSLFYLTLPPVIYRITNKDNKTLACGGLITVSGKNLLTSDKEFKVNVKSNNKNTTVFAQDEKILIVRDESRESSLFVTTFIGVRSGPSTTLTYIKPMISEIPTIENKIEKGILAIIRGYSFTDILNASLTVSSETVPLSCNLECSLSPNEILDDSDSSETNITNSNTDCLSCHSGSSVKNTSGVLYLLFNSTSFQYNVTIEEIKLSPSPNVSQRDVETKSSKPSNGLIIGSTIGSVGGALAIGALAYYFKIPFRVKKFIGKKF
Protein: Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15) (P35268)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}.
Interaction partners:
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS8
- Large ribosomal subunit protein eL43
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL6
Sequence:
MAPVKKLVVKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED
Protein: LIM homeodomain protein (Q4VJ29)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
Sequence:
MLDGIKIEDHPLRSGQATLGVMLGTECHHQAVCEGCQRPISDRFLMRVNESSWHEECLQCAVCQQPLTTSCYFRERKLYCKYDYQQLFATKCSGCLEKIAPTEFVMRALECVYHLNCFCCCVCDRQLRKGDEFVLKDGQLLCKSDYEREKDLLGSVSPDDSDSEKSEDEELDIKPEKGSGGTGKGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQEQQNSQRLGQEVMSNRMEGMMNSYTQLAPAQQQMVALENGYSTDPFQQGLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFMASSDAGSMQARVGNPIDRLYSMQSSYFAS
Protein: PSP1 C-terminal domain-containing protein (Q381W0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MFHDLTNVTQSKRQVHPHHMHESDMEVAARMTAPVFTTDEGIAEKLDQLSRKVDAIYGLMLHLVQQRQLPTAPELLTSTSQTSTIEAVHPAFPEEEPNFVSMLSSAMPHATHSAPQFFESPTHDPLTSGTIDTVTTPMVSTRDKEEEHIKATDNKRALSNPQSSSATRGDDHNSWKRHDCFILLVEFKCQRMKRCVSSSFITPGQYAIVQGDRGHDCGVVNQCSEWNAEKGCIVREESFDGNVTNVVRMKGEMGRVLRVATEEEVERLFGEISRNENLALKTCREIVARLGLDMDVVDCEYQFDQQKISFYYEASRSIDFRQLNSELFRIFGVRIWLQNVNNSVKNVVPAGAMSREEKTQYQKSGLRPPTYK