wanglab/gogpt-training-data huggingface dataset:
Protein: Paired-like homeobox 2b (Q5I7G4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Transcription factor SOX-10
- Dopamine beta-hydroxylase
- Heart- and neural crest derivatives-expressed protein 2
- Tyrosine 3-monooxygenase
- Transcription factor GATA-3
- Endothelin-3
- END domain-containing protein.
- N-myc protein
- Neurturin
- ALK tyrosine kinase receptor
Sequence:
MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGTGKKSDSREEDSKEAKATDPDSTGGPGPNPNPTSNCGGPSPTGGQVSATGNGPVEQVKTSVAGMGPTAPTQGWASAPGTITSIPDSLGGPFASVLSSLQRQNGAKATLVKTSMF
Protein: Predicted gene 572 (B1ARY8)
Organism: Mus musculus (Mouse)
Interaction partners:
- Olfactory receptor
Sequence:
MWGSVAVVWAICLACIQPAVFPWILPVRSNKDRPRPAHGALTEKVECFSDYMTLQIPSSHVQGLKQWLVGVLRLPGSKRAPNHLDSLLTKCGYLLHPAHEGGFIFRALYSGCFVQKEKANYRLEIRMFQKGAKRLKQSDRYIMRCPMMVARLGEQSVRCHPSFIQVSRPWPPRTDAGQTPWLLSLRGELVASLEDASLMGLEVDIGATMVTIQSPRQELLQRQEVWNTSLELLPLWLVSGSYAYSFEAACPLVSSQPGSEISVHIPKQRLGLVKRGSLVEESLSPRFLQVQQTDTFTVAEDRDFVIVSIPSMRLLQDQPCQKARESPGTQAFYRVDLSLDFAEMDSPVHWTVENFFQCVDSCGTDIDFEREGWNATRPVCSQRSEATRWGGGVGLSSSL
Protein: Putative gluconeogenesis factor (P75767)
Organism: Escherichia coli (strain K12)
Function: Required for morphogenesis under gluconeogenic growth conditions.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00973}.
Interaction partners:
- RNase adapter protein RapZ
Sequence:
MRNRTLADLDRVVALGGGHGLGRVLSSLSSLGSRLTGIVTTTDNGGSTGRIRRSEGGIAWGDMRNCLNQLITEPSVASAMFEYRFGGNGELSGHNLGNLMLKALDHLSVRPLEAINLIRNLLKVDTHLIPMSEHPVDLMAIDDQGHEVYGEVNIDQLTTPIQELLLTPNVPATREAVHAINEADLIIIGPGSFYTSLMPILLLKEIAQALRRTPAPMVYIGNLGRELSLPAANLKLESKLAIMEQYVGKKVIDAVIVGPKVDVSAVKERIVIQEVLEASDIPYRHDRQLLHNALEKALQALG
Protein: GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)] (Q8CFX1)
Organism: Mus musculus (Mouse)
Function: Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway. May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate. The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum. By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000305|PubMed:12831846}.
Interaction partners:
- 6-phosphogluconate dehydrogenase, decarboxylating
- Glucose-6-phosphate isomerase
- Hexokinase-3
- Hexokinase-2
- Hexokinase-1
- Hexokinase HKDC1
- Phosphoglucomutase-1
- Probable gluconokinase
- Pyruvate kinase PKM
- 6-phosphogluconolactonase
Sequence:
MLLAAMCLALLGCLQAQELKGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHSFSFHGAALTAPQQGQKLMDKVLESLSCPKDLVPSRCDELKGQFLQLSQYRQLKTVEDYQTLNKDIETQVQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVIRDTLQNHLTEILTLVAMELPLNISSSAAVLQHKLWAFQALRGLQKSSAILGQYQAYSGQVRRELQKPDGFQSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNRAYCTQSERHWVPEQSRCLPQQIIFYIGHGELGHPAILVSRNLFKPSLPTQKWKEVQDQPGLRLFGRPLSDYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLAFEVPRPYPGGAENGQLLDFEFSGGQLTFSQQQLEVLIPDLGSVPKPSDFQVLGARYRQSPLITAWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQAHLLQHVRVPYYNIHPMPVHLHQRLCAEEDQGAQTYASEISALVANSSFDLVLLGMGTDGHTASLFPQSPTGLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPLSGQLVWYMDYEAFLG
Protein: Methanol--corrinoid protein (Methanol:corrinoid methyltransferase 1 subunit of 27 kDa) (MT1 subunit 27 kDa) (Q46EH4)
Organism: Methanosarcina barkeri (strain Fusaro / DSM 804)
Function: Harbors a corrinoid prosthetic group and acts as a methyl group carrier in methanogenesis in the methanol pathway. The methyl group of methanol is first transferred to the corrinoid prosthetic group of MtaC in the cob(I)amide oxidation state. This reaction is mediated by MtaB. The methyl group from MtaC is then transferred to coenzyme M by MtaA.
Interaction partners:
- Methanol--corrinoid protein co-methyltransferase
- Methylcobamide:CoM methyltransferase MtaA
- Methanol-specific methylcobalamin: coenzyme M methyltransferase
- Methylcobalamin:coenzyme M methyltransferase
- Methanol:corrinoid methyltransferase
- Methanol:corrinoid methyltransferase
- Methanol corrinoid protein
- Methanol corrinoid protein
- Methylamine-specific methylcobalamin:coenzyme M methyltransferase
- Corrinoid protein
Sequence:
MLDFTEASLKKVLTRYNVALEKALTPEEAAEELYPKDELIYPIAKAIFEGEEDDVVEGLQAAIEAGKDPIDLIDDALMVGMGVVIRLYDEGVIFLPNVMMSADAMLEGIEYCKENSGATPKTKGTVVCHVAEGDVHDIGKNIVTALLRANGYNVVDLGRDVPAEEVLAAVQKEKPIMLTGTALMTTTMYAFKEVNDMLLENGIKIPFACGGGAVNQDFVSQFALGVYGEEAADAPKIADAIIAGTTDVTELREKFHKH
Protein: Putative uncharacterized oxidoreductase C513.07 (EC 1.1.1.-) (Q9UT59)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Large ribosomal subunit protein eL13
- Small ribosomal subunit protein uS3
- Brefeldin A resistance protein
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL18A
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein eS7
- Small ribosomal subunit protein uS14
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein uS15
Sequence:
MSGKLVLVTGVTGFIGAHVAEQLLQAGYRVRGTVRSMEKADELIRLNPGLKDKIEFVIVKDVSASNAFDGVLKDVELICHIASPFFVENVTDNKSQLLDPAVKGTLGILEAAQGVKSIKRIVITSSFAAVGNFQIDPHNNKVYTEKDWNPITYEEALTTDNGIVAYCASKKLAEEAAREYVKEKKPSYDICTINPPYVYGPPIHPMKNMDSLNTSNQIFWKLIDGSKEATPFYYYYVDVRDVAAAHVFALENAKLSNGRMLVSKGVFTTGDICKVLRKEFPNKSDVIAEPVDITVDPSFFKLDNSFSKSLGFKYHSDEECYVDTAKKLWERAEEFK
Protein: Splicing factor U2AF subunit (U2 snRNP auxiliary factor large subunit) (Q9W1T4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364135}.
Interaction partners:
- Splicing factor U2af 38 kDa subunit
- Splicing factor 3B subunit 1
- Probable small nuclear ribonucleoprotein G
- Branchpoint-bridging protein
- U1 small nuclear ribonucleoprotein 70 kDa
- Probable U2 small nuclear ribonucleoprotein A'
- Splicing factor 3B subunit 4
- Probable small nuclear ribonucleoprotein Sm D2
- BcDNA.LD23634
- LD24714p
Sequence:
MRRFRPMNRSWNALRSRSRSRSRSRSPFRSQSITRSRPTRSDTIYTERTRLQRRFSRPPSSWDIPPEGYNHLTPQQYKAMLASGQIASRILSDGVHGGESAAISMITRQARRLYVGNIPFGVTDEEMMQFFNHQIMALGFEAKSSHYMDGNAVLTCQTNLEKNFAFLEFRSIDEASQALNFDGMVFRGQTLKIRRPHDYQPVPSISVSAMESYRSFRVPAINVAQQPAVTLPVTTIVPDSPNKIYVGGLPTCLNQDQVKELLQSFGELKGLNLVMDTNTNLNKGFAFFEYCDPSVTDHAIAGLHGMLLGDRRLVVQRSIPGGKNAFPGHLPTVLQVPGISTLQDPGSPTETLCLLNMVRPEELLDDEEFEDIRTDIKQECAKFGEVRSIKIPRPIGQFPKRGCGKVFVQFESVEDSQKALKALSGRKFSGRIVMTSYYDPEKYLADDLQ
Protein: 32 kDa beta-galactoside-binding lectin (32 kDa GBP) (P36573)
Organism: Caenorhabditis elegans
Function: Binds galactose.
Interaction partners:
- Protein containing ALS2cr12
- Nicotinamide N-methyltransferase
Sequence:
MSAEEPKSYPVPYRSVLQEKFEPGQTLIVKGSTIDESQRFTINLHSKTADFSGNDVPLHVSVRFDEGKIVLNSFSNGEWGKEERKSNPIKKGDSFDIRIRAHDDRFQIIVDHKEFKDYEHRLPLSSISHLSIDGDLYLNHVHWGGKYYPVPYESGLANGLPVGKSLLVFGTVEKKAKRFHVNLLRKNGDISFHFNPRFDEKHVIRNSLAANEWGNEEREGKNPFEKGVGFDLVIQNEEYAFQVFVNGERYISFAHRADPHDIAGLQISGDIELSGIQIQ
Protein: Scarecrow-like protein 8 (AtSCL8) (GRAS family protein 30) (AtGRAS-30) (Q9FYR7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in plant development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Ketose-bisphosphate aldolase class-II family protein
- Bifunctional enolase 2/transcriptional activator
- Cytosolic enolase 3
- Enolase 1, chloroplastic
- Triosephosphate isomerase, cytosolic
- Triosephosphate isomerase, chloroplastic
- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1
- Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2
- Cleavage stimulation factor subunit 77
- aspartate-semialdehyde dehydrogenase
Sequence:
MESGFSGGGGGSDFYGGGGGRSIPGGPGTVINVGNNNPQTTYRNQIPGIFFDQIGNRVAGGNGFSGKRTLADFQAAQQHQQQQQQQPFYSQAALNAFLSRSVKPRNYQNFQSPSPMIDLTSVNDMSLFGGSGSSQRYGLPVPRSQTQQQQSDYGLFGGIRMGIGSGINNYPTLTGVPCIEPVQNRVHESENMLNSLRELEKQLLDDDDESGGDDDVSVITNSNSDWIQNLVTPNPNPNPVLSFSPSSSSSSSSPSTASTTTSVCSRQTVMEIATAIAEGKTEIATEILARVSQTPNLERNSEEKLVDFMVAALRSRIASPVTELYGKEHLISTQLLYELSPCFKLGFEAANLAILDAADNNDGGMMIPHVIDFDIGEGGQYVNLLRTLSTRRNGKSQSQNSPVVKITAVANNVYGCLVDDGGEERLKAVGDLLSQLGDRLGISVSFNVVTSLRLGDLNRESLGCDPDETLAVNLAFKLYRVPDESVCTENPRDELLRRVKGLKPRVVTLVEQEMNSNTAPFLGRVSESCACYGALLESVESTVPSTNSDRAKVEEGIGRKLVNAVACEGIDRIERCEVFGKWRMRMSMAGFELMPLSEKIAESMKSRGNRVHPGFTVKEDNGGVCFGWMGRALTVASAWR
Protein: cAMP-dependent protein kinase (EC 2.7.11.11) (Q4X0V1)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Interaction partners:
- cAMP-dependent protein kinase regulatory subunit
- Adenylate cyclase
- Ras-like protein B
- RAS small monomeric GTPase RasA
- non-specific serine/threonine protein kinase
- Mitogen-activated protein kinase mpkA
- Cell pattern formation-associated protein stuA
- cAMP-dependent protein kinase
- Lysophospholipase nte1
- Phosphodiesterase
Sequence:
MPTLGGLLKKRRTKDSHTLSKELESSSSPAAAQTQTSPNSADHDHHYQHYDQTHHHQHSASSNPSNNSATPSAAQPHRSSNDNPNRSSGTDQKSEGQTASMQFAVTQPHPSTHHNPRLHHLQQQQQQPQQQSHTSRLHNILHPSHHASSQASTEGHAHSQQANQTEARTTKGKYSLDDFTIQRTLGTGSFGRVHLVQSKHNHRFYAIKVLKKAQVVKMKQVEHTNDERRMLNRVRHPFLITLWGTWQDARNLYMVMDFVEGGELFSLLRKSQRFPNPVAKFYAAEVTLALEYLHSQQIIYRDLKPENLLLDRHGHLKITDFGFAKEVPDITWTLCGTPDYLAPEVVSSKGYNKSVDWWSLGILIFEMLCGFTPFWDSGSPVKIYENILRGRVKYPPYLHPDAVDLLSQLITADLTKRLGNLHGGSEDVKNHPWFAEVTWDRLARKDIDAPYVPPIRGGQGDASQYDRYPEETEQYGQQGEDVHGHLFPDF
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9VNV0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MAGLIGAANGKHHHPHLISPTHTSLPAGICSSDSGISTLSAISPPLSTSTTTASGAGGGVGGSPQLRTSPALSMLGSATATASGVTASSGCGLTAGILGPAASIDLGSSPLSHRNYSNSLKGFSFRRSFDDKIINTPYLSRAPAYTHGIPYPHFHGTQPAATTPHHLHLHHHGNGTAAGSGSGVGSGPGSGSGAGGLYQQPLSLASMTAALPLAPLYGSPLSLPLTSSQSTTKLSYRDDFLQQIGYLPTTRIYSTPTSIVDEDKAQQDFLSLSLSPPLNRRRDMPALRGPFVSLSEPRGTLSTTDEIYPDSSDSSLYVSDEEQEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQIDDEINSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACYDYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAHIVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWLEQEEFV
Protein: DNA-dependent metalloprotease SPRTN (EC 3.4.24.-) (Protein with SprT-like domain at the N terminus) (Spartan) (A0A1L8G2K9)
Organism: Xenopus laevis (African clawed frog)
Function: DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (By similarity). Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (By similarity). Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4 (By similarity). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs. May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis (By similarity). Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9H040}. Chromosome {ECO:0000269|PubMed:30595436}. Note=Localizes to sites of UV damage via the PIP-box (By similarity). Recruited to stalled replication forks at sites of replication stress (By similarity). {ECO:0000250|UniProtKB:Q9H040}.
Interaction partners:
- Abasic site processing protein HMCES
- Uncharacterized protein.
- Protein DDI1 homolog 2
- Endo/exonuclease/phosphatase domain-containing protein.
- RING-type domain-containing protein.
- DNA topoisomerase I
- DNA topoisomerase I
Sequence:
MGDMQMSVVDPTWELLDPNPDIRALFLEFNDTFFWGQLSGVEVKWSARMTLCAGVCSYEGRGGLCSIRLSEPLLKLRPRKDLVETLLHEMIHALLFVTHNNKDHDSHGPEFCKHMERINGRTGANISVYHNFHDEVDEYRKHWWLCNGPCQKRKPYFGYVKRAMNRAPSSLDPWWADHQRTCGGSFVKVKEPENYPQKRKRKNDPTISEVNSSSHVKGKSNGVDIRTVIPFSGTGYKLFEPNKSDAPLKILNINPTKDKAAVPLLNHTPPSTNINGTFLTNKIGSAKSTPAQSILTKVSVANTKVFINLNGSPIKLPSGSKNKSHQISSKQKSVLPFFKMQKDNSFDLTLPSPSIQSTSQKPQKDISFGFTLPSQSFPSTSPGSNSENKEPLYKKLQMNDRESFIIHSGNKTNVNDNKSCTGPAATTASGLNHTIKVSCPVCGTEVLECKINDHLDTCTSSGPQKDILLDVSLPLQSFPSTSQGSNSAIKEPLYKKLQINDKDSFIIHSGNKTNVNDNKSCTRPAATTASGFNHTIKVCCPVCGTDVLQDKINDHLDTCLQNCNT
Protein: Protein CROWDED NUCLEI 4 (Protein LITTLE NUCLEI 4) (Q9FLH0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (By similarity). Required for nucleus structure organization (e.g. size and shape). Involved in the maintenance of interphase chromocenter integrity and organization.
Subcellular location: Nucleus membrane {ECO:0000269|PubMed:23396599}; Peripheral membrane protein {ECO:0000269|PubMed:23396599}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:F4HRT5}. Nucleus lamina {ECO:0000269|PubMed:23396599}. Cytoplasm {ECO:0000269|PubMed:23396599}. Note=Recruited to the nucleus envelope (NE) by SUN proteins and is immobilised therein (By similarity). Localized frequently to the nuclear periphery as punctate structures of different sizes. During prometaphase to anaphase, localized diffusely in the cytoplasm. Later assembled into punctate structures in the cytoplasm and then to the chromatin surface. Relocalized in part to the nuclear periphery during late telophase, the other part is still localized on the punctate structures (PubMed:23396599). {ECO:0000250|UniProtKB:F4HRT5, ECO:0000269|PubMed:23396599}.
Interaction partners:
- Protein KAKU4
- SUN domain-containing protein 1
- Nuclear envelope-associated protein 1
- Nuclear pore complex protein NUP1
- SUN domain-containing protein 3
- Nuclear envelope-associated protein 3
- Plant UBX domain-containing protein 3
- WPP domain-interacting tail-anchored protein 2
- SUN domain-containing protein 2
- WPP domain-interacting tail-anchored protein 1
Sequence:
MATSSRSERFPITPSTAATNRLTITPNSRVLKSPLTEEIMWKRLKDAGFDEQSIKNRDKAALIAYIAKLESEVYDYQHNMGLLLLEKNELSSQYEEIKASVDESDLTHMREKSAYVSALAEAKKREESLKKDVGIAKECISSLEKTLHEMRAECAETKVSAGSTMSEAHVMIEDALKKLADAEAKMRAAEALQAEANRYHRIAERKLKEVESREDDLTRRLASFKSECETKENEMVIERQTLNERRKSLQQEHERLLDAQVSLNQREDHIFARSQELAELEKGLDTAKTTFEEERKAFEDKKSNLEIALALCAKREEAVSERESSLLKKEQELLVAEEKIASKESELIQNVLANQEVILRKRKSDVEAELECKSKSVEVEIESKRRAWELREVDIKQREDLVGEKEHDLEVQSRALAEKEKDITEKSFNLDEKEKNLVATEEDINRKTTMLEDEKERLRKLDLELQQSLTSLEDKRKRVDSATQKLEALKSETSELSTLEMKLKEELDDLRAQKLEMLAEADRLKVEKAKFEAEWEHIDVKREELRKEAEYITRQREAFSMYLKDERDNIKEERDALRNQHKNDVESLNREREEFMNKMVEEHSEWLSKIQRERADFLLGIEMQKRELEYCIENKREELENSSRDREKAFEQEKKLEEERIQSLKEMAEKELEHVQVELKRLDAERLEIKLDRERREREWAELKDSVEELKVQREKLETQRHMLRAERDEIRHEIEELKKLENLKVALDDMSMAKMQLSNLERSWEKVSALKQKVVSRDDELDLQNGVSTVSNSEDGYNSSMERQNGLTPSSATPFSWIKRCTNLIFKTSPEKSTLMHHYEEEGGVPSEKLKLESSRREEKAYTEGLSIAVERLEAGRKRRGNTSGDETSEPSNNKKRKHDVTQKYSDEADTQSVISSPQNVPEDKHELPSSQTQTPSGMVVISETVKITRVTCETEVTNKVTTLDCSESPSEAGRKMGEETEDGDCNQTGINASETVIHNEAATEDICT
Protein: 4-chloro-allylglycine synthase (EC 1.14.99.-) (L-2-amino-4-chloropent-4-enoate synthase) (F8JJ25)
Organism: Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057) (Streptomyces cattleya)
Function: Involved in the biosynthesis of terminal alkyne-containing amino acids such as L-propargylglycine (Pra) and L-beta-ethynylserine, that are produced as antibiotics by S.cattleya. Catalyzes an oxidative C-C bond cleavage in 4-chloro-L-lysine to form 4-chloro-allyl-L-glycine (also named L-2-amino-4-chloropent-4-enoate), with release of formaldehyde and ammonia. Is also able to react with L-lysine directly to produce allylglycine in vitro.
Interaction partners:
Sequence:
MTDLNTPESTSKPVWEHFDHVEPGIRRRIAVADPEIKEYLDGMLARIASHRGVEHPFLNAYRTTALDPEQERHLFSECYYFFRYLPFYITGMAVKTRDEMILREIILNVADEVGSDPTHSTLFADFLARIGIDKEHLDGYQPLEVTRQLNDGIRHLYTETSINKALGALYADETMSSIMVSKINDGLRNQGYDDDLRHFWQLHIDVEVGHSNSVFNAIAPYVGSKAARAEFEEGVFEFLGLVERYWDGVRELVGIGK
Protein: Amphiphysin (P50478)
Organism: Gallus gallus (Chicken)
Function: May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Interaction partners:
- Bridging integrator 1
- Dynamin binding protein.
- Myc proto-oncogene protein
- Dynamin 1
- Epsin 2
- Synaptojanin 1.
- Clathrin heavy chain
- STARD3 N-terminal like
- FES proto-oncogene, tyrosine kinase.
- Clathrin heavy chain
Sequence:
MADMKTGIFAKNVQKRLNRAQEKVLQKLGKADETKDEQFEEYVQNFKRQEAEGSRLQRELRAYLAAIKGMQDASKKLTESLHEVYEPDWYGREDVKMIGEKCDELWEDFHQKLVDGSLLTLDTYLGQFPDIKTRIAKRSRKLVDYDSARHHLEALQSSKRKDEGRITKAEEEFQKAQKVFEEFNTDLQEELPSLWSRRVGFYVNTFKNVSSLEAKFHKEIALLCHKLYEVMTKLGDQHADKAFTIQGAPSDSGPLRIAKTPSPPEEVSPLPSPTASPNHMLAPASPAPARPKSPTQLRKGPPVPPLPKLTPTKELQQENIINLFDDNFVPEINVTTPSQNEIPETKKVESLLDLDFDPFKPEVVSTGVTHSPMSQTLPWDLWTTTSELVQPASSTAFNGFAQDTTAFAVQSNENVTETLTEAEEAPLGELKVEETPTAAVVEKEAILAEPDEPTEQAAESIEAGDKETTGIAEKESEVVSAAGGAVAVEDSVVVAAGAGEGAVRTEQEAAAEGDKPQGEEKDVDVSQEKVSSIPSVVIEPASNNEGEGEEHHVIMNESKDAAAEMGTQGTDSETSQIGSEQKATEEIQTTPSQDQPASAGDTASDMPPGFLFKVEVLHDFEAANSDELNLKRGDIVLVIPSETTADQEAGWLTGIKESEWLQYRDANSYKGLFPENFTRHLE
Protein: Low-density lipoprotein receptor-related protein (B2RYI1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
METAPTRAPPPPPQPLLLLLALCCSLVPAAASPLLLFANRRDVRLVDAGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAAQNIVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGEAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEKRKEILSALYSPMDIQVLSQERQPPFHTPCEEGNGGCSHLCLLSPREPFYSCACPTGVQLQDNGKTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVGDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIVLHPVMGLMYWTDWGENPKIECANLDGRDRHVLVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVINIDGTKRQTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADGNGGCSHLCFFTPHATKCGCPIGLELLSDMKTCIIPEAFLVFTSRATIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCVHSNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPSTFLLFSQKFAISRMIPDDQLSPDLILPLHGLRNVKAINYDPLDKFIYWVDGRQNIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLDGDAMGVVLRGDRDRPRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVLFTTGLIRPVALVVDNALGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPVGLTVLGRHLYWIDRQQQMIERVEKTTGDKRTRVQGRVTHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECADQSDEEGCPVCSASQFPCARGQCVDLRLRCDAVCLPNQFRCASGQCVLIKQQCDSFPDCADGSDELMCEINKPPSDDVPAHSSAIGPVIGIILSLFVMGGVYFVCQRVMCQRYTGASGPFPHEYVGGTPHVPLNFIAPGGSQHGPFPGIPCSKSMMSSVSLVGGRGSVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPSTARPYRPYIIRGMAPPTTPCSTDVCDSDYSTSRWKTSKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPVTERSYCHLFPPPPSPCTDSS
Protein: Mitochondrial import receptor subunit TOM6 (Mitochondrial import site protein ISP6) (Translocase of outer membrane 6 kDa subunit) (P33448)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM6 is involved in assembly and stability of the TOM complex.
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein.
Interaction partners:
- Mitochondrial import receptor subunit TOM40
- Mitochondrial import receptor subunit TOM22
- Mitochondrial import receptor subunit TOM5
- Mitochondrial import receptor subunit TOM7
- Sorting assembly machinery 37 kDa subunit
- Mitochondrial import receptor subunit TOM20
- Sorting assembly machinery 50 kDa subunit
- Mitochondrial import receptor subunit TOM70
- Sorting assembly machinery 35 kDa subunit
- Mitochondrial distribution and morphology protein 10
Sequence:
MDGMFAMPGAAAGAASPQQPKSRFQAFKESPLYTIALNGAFFVAGVAFIQSPLMDMLAPQL
Protein: RNA polymerase II C-terminal domain phosphatase-like 5 (FCP-like 5) (EC 3.1.3.16) (Carboxyl-terminal phosphatase-like 5) (AtCPL5) (CTD phosphatase-like 5) (F4JCB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the dephosphorylation of 'Ser-2' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II. Regulates positively abscisic acid (ABA) and drought responses, including the regulation of specific genes expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:21231936}.
Interaction partners:
- Transcription initiation factor IIF subunit alpha
- SCP1-like small phosphatase 4b
- SCP1-like small phosphatase 4
- Protein GOLVEN 1
- Mitotic checkpoint protein BUB3.1
- Protein DETOXIFICATION 19
- Protein PIN-LIKES 7
- DNA-directed RNA polymerase II subunit 4
- RNA polymerase II C-terminal domain phosphatase-like 2
- Protein SMAX1-LIKE 2
Sequence:
MFVAKNLSPERESKRQKKEPEIMEPSFPLLSPNNCGHWYIRYGFCIVCKSTVDKTIEGRVFDGLHLSSEALALTKRLITKFSCLNMKKLHLVLDLDLTLIHSVRVPCLSEAEKYLIEEAGSTTREDLWKMKVRGDPISITIEHLVKLRPFLCEFLKEANEMFTMYVYTKGTRPYAEAILKLIDPKKLYFGHRVITRNESPHTKTLDMVLADERGVVIVDDTRKAWPNNKSNLVLIGRYNYFRSQSRVLKPHSEEKTDESENNGGLANVLKLLKGIHHKFFKVEEEVESQDVRLTMSVVENFSSEPKAKRRKIEPTINESSSSLSSSSSCGHWYICHGICIGCKSTVKKSQGRAFDYIFDGLQLSHEAVALTKCFTTKLSCLNEKKLHLVLDLDHTLLHTVMVPSLSQAEKYLIEEAGSATRDDLWKIKAVGDPMEFLTKLRPFLRDFLKEANEFFTMYVYTKGSRVYAKQVLELIDPKKLYFGDRVITKTESPHMKTLDFVLAEERGVVIVDDTRNVWPDHKSNLVDISKYSYFRLKGQDSMPYSEEKTDESESEGGLANVLKLLKEVHQRFFRVEEELESKDVRSLLQEIDFELNVESVE
Protein: c-Myc-binding protein (Q38E79)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSYQSSEAKKEEFRKYLEGKQVIDTLTRVLVNLYEEPEKPDDPVDFIKKVLGGASTADYEALQQENACLKAEVAALKKRLNEEH