wanglab/gogpt-training-data huggingface dataset:
Protein: Ras-related protein Rab-17 (EC 3.6.5.2) (P35292)
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration.
Subcellular location: Recycling endosome membrane {ECO:0000269|PubMed:21291502, ECO:0000269|PubMed:22291024, ECO:0000269|PubMed:9490718, ECO:0000269|PubMed:9624171}; Lipid-anchor {ECO:0000305|PubMed:9624171}; Cytoplasmic side {ECO:0000305|PubMed:9624171}. Melanosome {ECO:0000269|PubMed:21291502}. Cell projection, dendrite {ECO:0000269|PubMed:22291024}. Note=According to a report the protein is localized at the basolateral and apical plasma membrane of kidney epithelial cells (PubMed:8486736). It was later shown to localize to the apical recycling endosome in epithelial cells (PubMed:21291502). In neurons, localizes to the cell body and dendritic shaft and spine (PubMed:22291024). {ECO:0000269|PubMed:21291502, ECO:0000269|PubMed:22291024, ECO:0000269|PubMed:8486736}.
Interaction partners:
- Rab5 GDP/GTP exchange factor
- Rab GTPase-binding effector protein 1
- Rabenosyn-5
- Early endosome antigen 1
- DCC-interacting protein 13-alpha
Sequence:
MAQAAGLPQASTASGQPYVSKLVLLGSSSVGKTSLALRYMKQDFSNVLPTVGCAFFTKVLDLGSSSLKLEIWDTAGQEKYQSVCHLYFRGANAALLVYDITRKDSFHKAQQWLEDLEKEFQPGEVVVMLVGNKTDLGEEREVTFQEGKEFAESKSLLFMETSAKLNYQVSEIFNTVAQELLQRAGDTGSSRPQEGEAVALNQEPPIRQRQCCAR
Protein: Cysteine desulfurase (EC 2.8.1.7) (Selenocysteine beta-lyase) (SCL) (Selenocysteine lyase) (EC 4.4.1.16) (Selenocysteine reductase) (Q9EXP2)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Function: Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12876288}.
Interaction partners:
- SufC protein
- SufD protein
- SufB protein
- Cysteine desulfuration protein SufE
- Thioredoxin reductase
- Cystathionine gamma-synthase
- Nitrogen fixation protein NifU
- Iron-sulfur cluster assembly scaffold protein IscU
- NifQ protein
- Predicted Fe-S metabolism protein
Sequence:
MNYPVEHYPIDRVRADFPILQQSVNGQPLAYLDSAASAQKPLAVIDRERDFYLHEYAAVHRGIHTLSARATSAMEEVRAKVATFIHAASAEDIVFVRGTTEAINLVANSYGRTAFQPGDNLVISEMEHHANIVPWQMLAQARGLTLRVLPITDDGELDMAQLPALLDERTRLVAVTQVSNVLGTVNPLAEIIRQAHACGAKVLVDGAQAVMHQAVDVQALDCDFYAFSGHKLYGPSGIGVLYGKSELLQAMPPWEGGGAMIREVSLTQGTTYADPPWRFEAGSPHVAGIIGLGAALDYVSALGVDAIQAHEGLLMRYALASLAEVPTLRLYGPVHRQGVIAFNLGRHHAFDVGSFLDQYGIAIRTGHHCAMPLMSRYGVPSMCRASLALYSCQDEIDRLVAGLHRIHRLLGE
Protein: Serine/threonine-protein kinase BSK (EC 2.7.11.1) (Brassinosteroid-signaling kinase) (Q9SR39)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193, ECO:0000256|RuleBase:RU369005}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193, ECO:0000256|RuleBase:RU369005}.
Interaction partners:
Sequence:
MIERTNLIVLAADNKEEDEGSTCPNFLEFSLEQLRVATDGFSADNIVSEHNERVPNIVYKGQLNDGRKIAVKRFQRLSWPDSLEFIEEAQAVGRCRSEHMANLIGCCSEGHERLLVAEYMPNETLAKHLFHWEKRPMKWEMRLRVALHTATALEYCNDWGIDLYHDLNTYRILFDKVGNPRLSCFGLMKCSREGKSYSTNLAFAPPEYLRLGTVIPESVTFSFGTLLLDLMSGRHIPPNHALDLFRGKNYLVLMDSALDGQFSDEDRTELIHLASRCLRPEPDERPSIKFLMSALSRLEKRAELWPNVKEENIPTPSYTEPATKEPLPLTPFGEACWRVDLSGMHELLEKLGYGEDDVVVTNEFSFQMWTGQMQENMDYKKHGDAAFRAKDFETAIEFYTEFMSGAPVVSPTVLARRCLCYLMSDMFREALSDAMQTQVASPEFSIALYLQAACLLKLGMEAEAKEALRHGSSLEAF
Protein: Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) (P21451)
Organism: Rattus norvegicus (Rat)
Function: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P24530}; Multi-pass membrane protein. Note=internalized after activation by endothelins. {ECO:0000250|UniProtKB:P24530}.
Interaction partners:
- Endothelin-1
- Endothelin-3
- Endothelin-2
- Endothelin-1 receptor
- Guanine nucleotide-binding protein G
- Angiotensinogen
- Guanine nucleotide-binding protein subunit alpha-13
- Kininogen-1
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
Sequence:
MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
Protein: Uncharacterized protein (Q585Z3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MEDPRDNPNPRNSRSDHSGNRLSSLRRHYHSDSEESDHFFPEHLQVIELEPTSFITEKDAPLVTEVFESCDSSEDVTLEAPVGVEVELSGPGVLRGVRIPTGKVKEKLDSKNKQISRLKSVRNGEPPKTNMKLNERGIMSTKRNKPVMRTRELNSISDEEYRR
Protein: Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD) (O35103)
Organism: Mus musculus (Mouse)
Function: May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Interaction partners:
- Mimecan
- Fibromodulin
- Prolargin
- Lumican
- Asporin
- Aggrecan core protein
Sequence:
MGFLSPIYVLFFCFGVRVYCQYEAYRWDDDYDQEPNEDYDPEFQFHQNIEYGVPFYNNILGCAKECFCPTNFPTSMYCDNRKLKTIPIIPMHIQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLSNLQQLHLEHNNLEEFPFPLPKSLERLLLGYNEISILPTNAMDGLVNVTMLDLCYNHLSDSMLKEKTLSKMEKLMQLNLCNNRLESMPLGLPSSLMYLSLENNSISSIPDNYFDKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPRNLEHLYLQNNEIESINVTMICPSPDPVHHHHLTYLRVDQNKLKEPISSYIFFCFPRIHSIYYGEQRSTNGETIQLKTQVFRSYQEEEEEDDHDSQDNTLEGQEVSDEHYNSHYYEMQEWQDTI
Protein: Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain] (Q04756)
Organism: Homo sapiens (Human)
Function: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.
Subcellular location: Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
Interaction partners:
- Kunitz-type protease inhibitor 1
- Kunitz-type protease inhibitor 2
- Immunoglobulin heavy variable 3-43D
- Probable non-functional immunoglobulin heavy variable 3-16
- Hepatocyte growth factor
- WD repeat-containing protein 90
- Hepatocyte growth factor receptor
- Inactive tyrosine-protein kinase 7
Sequence:
MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILVTSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLHACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
Protein: Cytochrome c biogenesis protein CcsA (P0C375)
Organism: Oryza sativa (Rice)
Function: Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01391}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01391}.
Interaction partners:
Sequence:
MLFATLEHILTHISFSTISIVITIHLITLLVRELGGLRDSSEKGMIATFFCITGFLVSRWASSGHFPLSNLYESLIFLSWALYILHMIPKIQNSKNDLSTITTPSTILTQGFATSGLLTEMHQSTILVPALQSQWLMMHVSMMLLSYATLLCGSLLSAALLMIRFRKNLDFFSKKKKNVLSKTFFFNEIEYFYAKRSALKSTFFPLFPNYYKYQLIERLDSWSYRVISLGFTLLTIGILCGAVWANEAWGSYWNWDPKETWAFITWTIFAIYLHSRTNPNWKGTKSAFVASIGFLIIWICYFGINLLGIGLHSYGSFTLPI
Protein: Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein) (P28360)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P13297}. Note=Interaction with PIAS1 is required for localization to the nuclear periphery (By similarity). {ECO:0000250|UniProtKB:P13297}.
Interaction partners:
- Histone H1.5
- Paired box protein Pax-9
- Homeobox protein MSX-2
- Bone morphogenetic protein 4
- Protein odd-skipped-related 2
- LIM/homeobox protein Lhx8
- Cysteine/serine-rich nuclear protein 1
- Transforming growth factor beta-3 proprotein
- Lymphoid enhancer-binding factor 1
- Interferon regulatory factor 6
Sequence:
MAPAADMTSLPLGVKVEDSAFGKPAGGGAGQAPSAAAATAAAMGADEEGAKPKVSPSLLPFSVEALMADHRKPGAKESALAPSEGVQAAGGSAQPLGVPPGSLGAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKPERTPWMQSPRFSPPPARRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYGASGPFQRAALPVAPVGLYTAHVGYSMYHLT
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (A0A2R8YFK5)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
XAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED
Protein: Small ribosomal subunit protein uS9 (40S ribosomal protein S16) (Q9W237)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL3
- Eukaryotic translation initiation factor 4C
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein uL5
- Small ribosomal subunit protein eS19A
- IP17351p
Sequence:
MQQKRREPVQAVQVFGRKKTATAVAYCKRGNGLLKVNGRPLEQIEPKVLQYKLQEPLLLLGKEKFAGVDIRVRVSGGGHVAQIYAIRQAISKALVAFYQKYVDEASKKEIKDILVQYDRTLLVGDPRRCEPKKFGGPGARARYQKSYR
Protein: CzcR (CzrR protein) (Response regulator) (Heavy metal response regulator transcription factor) (Q9RLJ1)
Organism: Pseudomonas aeruginosa
Interaction partners:
Sequence:
MRILIIEDEVKTADYLHQGLTESGYIVDRANDGIDGLHMALQHPYELVILDVNLPGIDGWDLLRRLRERSSARVMMLTGHGRLTDKVRGLDLGADDFMVKPFQFPELLARVRSLLRRHDQAPMQDVLRVADLELDASRHRAFRGRVRINLTTKEFALLHLLMRRNGDVITRTQIISLIWDMNFDNDSNVVEVAICRLRAKIDDGFDLKLIHTIRGVGYVLEARR
Protein: Candida glabrata strain CBS138 chromosome E complete sequence (Q6FUY3)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Serine/threonine-protein phosphatase
- Calcineurin subunit B
- Candida glabrata strain CBS138 chromosome M complete sequence
Sequence:
MDSLVTDTIILTSNERDITGQEILPILASWFEDNVLSNIQVLPANPIQLLLLKNFKRCLIICPDHAVSNAVMQKLKLKVPLPDLIFNYSITDSQNNSSVKKDYLKVPEHQRLFLISPPSSPPPEFDYSKCEDKPSFKTHAHQPEKILRQATSFVAIESQVGTITVNTCDDYNNGGPGLEGVRTALPPKSIFDDIDE
Protein: Genome polyprotein (Q66776)
Organism: Equine rhinitis B virus 1 (strain Equine/Switzerland/P1436/71/1971) (ERBV-1) (Equine rhinovirus type 2)
Subcellular location: Host cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004295}. Host nucleus {ECO:0000256|ARBA:ARBA00004147}. Virion {ECO:0000256|ARBA:ARBA00004328}.
Interaction partners:
Sequence:
MVTMAGNMICNVFAGLATEICSPKQGPLLDNELPLPLELAEFPNKDNNCWVAALSHYYTLCDVTNHVTKVTPTTSGIRYYLTAWQSILQTDLFNGYYPAAFAVETGLCHGPFPMQQHGYVRNATSHPYNFCLCSEPVPGEDYWHAVVKVDLSRTEARVDKWLCIDDDRMYLSGPPTRVKLASSYKIPTWIESLAQFCLQLHPVQHRRTLANSLRNEQCRGAGHSRPEGGHNNESGNNGTIVNNYYMQHYQNSVDLDGMTSQNIGGQPGSSSNPFSSILDILGTASSVALLDQDTEDVTRQPDRIVTVLDGNTSRTTQSSVGILRGYNYAPGKHTQPSSAQDTPSKAEQSVERGFTFQLAQWETSRNIWDHLTIPLPMCPGLIKVSGMYKAFIETHAYIKNGWKIQVQCNASQFHSGCLLVAMIPEYLSTAQQDFLGSWRDKTTDSTPGTWVWNTYEAFPPGFPPQQITLFPHQFLNLRTNTTVDLEVPYTNFAPSSSPTLHCPWTLVIVVVSPLQFGTGAPTQVQITTTITPTDFVANGLRQAVAQGIPGTQPYDRQFVSSEPSAPPPVYTPSWLPERSFIPGKFTDFLQVAVIPTLAEVSVQNYKPVPSFPVSNVLQTKPLVNTDLTFTSMTFRNTYVSALSLQYTQYRGSICMDLLFTGSAMCQGKFVVCYVPPGREPQSLDEAMQGTYSIWDLGLNSSFKFVVPYISASAYRFTHEDDQPSALNAVGWLQIYQLTNLTFPPNVPTRADVLVFFSAGSDFCLRFPVDTYPRTEGTENMETGAVGPSDPSETSDSHSFAMPNVVSHTNLEFLFDRYFFSGFANSCDVTANTTHTHSGDTQLNPFVTPNFKLDKTVRDYMLRAFTYFTADLGVAVQPTSVSSKPLPAVDYWVGWRPVGAPEPKLLAFSAPSPGDTVTAVKRSSVLSGGFCPIIHSVIGQGLNQVQMSIPYTTPLSAIPTSYCGYADYKKKPRLFGHPPAAHFGTLSIRVRNVDLLPEQTKKEDDPLVDLRFALFTRFRNLKAYAPRPFTRVPNSPHEQGTASRTLVRTNHITAEFVEKTPLNGLAAVFTSLSTSGYSTKLVSEPIPEATLSTILSEGATNFSLLKLAGDVELNPGPTIWSVMPGGELIEFATKVSQVYKTIKEKCTDPTTWIKAVRRLLRLLAVVSAWKHGDWFSMICLLVDLGFDLAQLSYKTFWQYLTKPFADAGLKFDFARDLTRRFRREQPRAPEVSPEEQRMAYGADFRQAVQYQENLQAPRRSWRERAQDTYRSIRRTFFDDSSSESEDGEPEVPQFRPQVYPRPRSMRVVRHPMTARRAQRVIDMGYSDYETAVENPFFISDLSSPEEEEPIPYEQARRQVPRVHFRESRGPEPTLRPRPGLMHRLAQRVHCEENQALLSEGISSTLSVLNGFFNLFKNVQWFLDFLKSCYGKLSKQLKPMQSLRDKVLQTYADSIAEFMTPSAQKKELYLQNHYDAVEAGLNSIAAAWKDLANKCYAYSRPEPVCILLKGRAGQGKSVAATVIAKAVSIVNTGKESVWTLPTDSDFFDGYAGQNVVIIDDLGQNPDGKDFRNFCQMVSSTVFLPPVADLAHKGIPFTSPVIIATTNKNENFLPVTVSDQEAVTRRYWKVIDVSADDQYKTVDGRLDYAKATQPTQIPPELAVFKTHVPLLKGALRDCQRTNRSGARVLNLYDVISAICVEVDRREQLRSNLGGIFAQSRDRHYQRDREYYDEYGTAEHRRRFVEQNPTFHFKETEADFYERVAFLSGIHGRKQSILKKIKEWFADGVRVRNLLGDAALALSLLTSILSFSLVIYSGVKTYQEFSRKHKPVRQPVYNAWEDFDEDCIFEQSRAYNIPNVRQRLRKQLAVRAENLCPSHDVTPDVEAHIPQGPVCEVDPGVPLVAQGASTGLTVNSLSLLNNVVPVTVSTVIETENGPLSQIVSECCGTYLYNKVMIMPRHILIKDWTHITAGRNSATRDQLEAVDVIDQFDMPSDAVAVKFPDKRGSSYKNIMHHLASTLPIRGKPVFILVNNNVAGRAVVHGTYIGCTQKITTLDGFTFPNVSSYKATTHLGMCGAPVIANENGNGKIIGFHCAGTGLVGYASNLTKMSANNICKVWGDPVAQGWTYFDTTHTPVHVPRKTKLRPTVAINTFECDVEPAVLSKFDRRLEEPDSFELTLLHKNDRRYPEDTSMDKHLEAAVEAYASSLFAQIGTDNGIISEYEAVTGIENLDSVETTTSPGLPYTTAGIPREALFDPDKTQLIGPAAERLQEFLRGDFSKHVFQTFLKDELRSKAKVRAGNTRVVEVAAVDHVVAGRMLLGKFTAKMHANNGLGIGSAVGCNPDVDFTRFAYQILEWDYVYDIDYKNFDASHSPKVFQYLKKLLSPENGFDVRLQKYIDSLCYSKHQFGDTYYECEGALPSGCSATSILNCLMNNIVLRAAAYDVFTNYEEGDLAFLTYGDDVLLCANQPLPLERFRKSLAKLGYTITPADKSSVFPEVSTLADVVFLKRRFKPDEEFPFLFKPVMDVRNLQDHLRYAKPGTLREKLLSTTDLAVHLGPLEYARLFRPFVEVGYCVRAFGDARRAWLRNFDL
Protein: Golgin subfamily A member 6-like protein 2 (Q8N9W4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPETTTSEGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDVETGGEAAGAGEADVGAGGEDAGSGAEDVGPGGEDVGAGREAAGEGGENAGAEEDVAAGGEDAGGEEDAGAGEEDMGPGGEDARGGEDAGAGEEDAGGGGDDAGAGGEDAGAGREDAGAGGEDVGAGREDAGAGGEDVGAGGEDVGAGRRRCGSSRGCRNRRRSCGNTRRCRSRRSGAEDVGPEGEDVGAGREAAGEGGENAGAEDVAAGGEDAGEEEDAGGEDAGAAREDAGAGGDDVGAGREDAGAGGEDVGAGGEDAGAGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDVGPGGEDVGAGGEDVGAGGDAREGGEDTRSEREDAGEAARARGAVLRALPPSLQSSL
Protein: Required for excision 1-B domain-containing protein (Q96EN9)
Organism: Homo sapiens (Human)
Interaction partners:
- Cytokine receptor-like factor 1
Sequence:
MITETAAEPTVPAVPAAEEATEARGREEPAWPWKDAPIRTLVQRIHQLQAERAQGFRRLEEWLAPVQGLRAWGRGLRVPTCRRGHRQYLRSGPDYDFARYRSTVHGVTQAFAAASREVLAVEAELGGPRRQPLLAGHVRSLQELEQTRLGTVALLQLMETPELAGQEDAVRMQQLKMKVIKTMEAISEVLQDLRFDAESAE
Protein: Protein transport protein Sec61 subunit gamma (P60058)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:36261528, ECO:0000269|PubMed:8107851}; Single-pass membrane protein {ECO:0000269|PubMed:36261528}.
Interaction partners:
- Protein transport protein Sec61 subunit beta
- Protein transport protein Sec61 subunit alpha isoform 1
- Large ribosomal subunit protein eL19
- Ribosomal protein L26
- Ribosomal protein L35.
- 40S ribosomal protein S30
- Ubiquitin-like domain-containing protein.
- Ubiquitin-like domain-containing protein.
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein uL4
Sequence:
MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG
Protein: Cell envelope regulator (DNA-binding response regulator) (Q9A223)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Interaction partners:
- histidine kinase
- histidine kinase
- Sensory/regulatory protein RpfC
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
Sequence:
MFRLMAQRKTLLLIDDDDDLRGALAEQLALHEEFAVNEASSAGEGVKLSRELKPDLILLDVDLPDMDGREACRLMRKNGVTAPVIMLTAAASDSDTILGLESGANDYVTKPFRFGVLLARIRAQLRSYEASEDALFRIGPYEFRPSAKLLVDEKQKKVRLTEKETNILKYLYRAGSKPVSREELLTEVWGYNAGVTTHTLETHVYRLRQKIEPDPTVARILITEMGGYRLQP
Protein: C4H2-type domain-containing protein (Q23664)
Organism: Caenorhabditis elegans
Interaction partners:
- Semaphorin-1A
Sequence:
MTATTVSPILGAESILSMSELHKVANAKTKVDDYFAKRNELLEELSELENTEKFIKETAKTIDELNKEKEEHSEIIQLINQDKSDLEREIAAAETEKKDRESKIVKRYEALLKLIESTNEKLKETGCDIALSQDDLPQTHLKIEPPAAPVTPVLSGGLPSPFPNFNFRNLFQPMLLEQLGSFSTNSPTPQFRPPPHMAAAMQHHQLKVTDHQSPPMKTCQSCYQQIHRNAPICPMCKSKSRSKNPKKPKRKDA
Protein: Ecto-NOX disulfide-thiol exchanger 1 (Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase) (cCNOX) (Cell proliferation-inducing gene 38 protein) (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] (Q8TC92)
Organism: Homo sapiens (Human)
Function: Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11360993}. Secreted, extracellular space {ECO:0000269|PubMed:11360993}. Note=Extracellular and plasma membrane-associated.
Interaction partners:
Sequence:
MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT
Protein: XIAP associated factor 1 (M0R7W3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MEDDFQVCRNCKRSVASSHFTLHEAHCLRFLVLCPECEEPIPESKMKEHVEAVHQQKQCSAPRTVTYLRDGRTVVLPSTLPLMNTGNQTSTVSKDVRPKTKNRNSSTKRETKDQSGAVDLPLKSRLQQRTALPKGEETAYDILRKCRQCRILLPLPILNEHQEKCLRLAQQKKLVRRASWILKSTSSQ
Protein: Exonuclease, putative (Q381I6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- TATA box-binding protein-like 1
Sequence:
MSANKHGHSEKSSTEAMDSDLPDSLPSSWSEALSGWDGPCDGEQVQKKQRRENTTAHPSDAVQTSAMGVSLLLGAPHAPPSSAPPTIVERSVLSSKRLQPLSAVCIDVETTGIAPTKDEIISIAVVELLFGAAGHNQWELSGRSFHRLVKPTKKVSSSAYRVHKLTSKVLERQPPFAAILPDLAAFLSDVRSGSTSTAAGDIHYKGPGGTNNVERVPLSSGGAAATVSVSRPSFQVEGCAAKVGGFLTALQSSCRNNRTLVFPPVIAHNAAFDRNFLYQSALRNGWEVVWDKQSPLTCTMSMFRALYPECPTNLTKACSLAGIDAAGREDRHDALQDAQLCGHLFIYLTEAWKSCSKRDPDNTETV
Protein: Secreted protein (O06354)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Interaction partners:
Sequence:
MNIRCGLAAGAVICSAVALGIALHSGDPARALGPPPDGSYSFNQAGVSGVTWTITALCDQPSGTRNMNDYSDPIVWAFNCALNVVSTTPQQITRTDRLQNFSGRARMSSMLWTFQVNQADGVACPDGSTAPSSETYAFSDETLTGTHTTVHGAVCGLQPKLSKQPFSLQLIGPPPSPVQRYPLYCNNIAMCY
Protein: Sodium-dependent phosphate transport protein 2B (Na(+)-dependent phosphate cotransporter 2B) (Sodium/phosphate cotransporter 2B) (Solute carrier family 34 member 2) (Q9DDS6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}.
Interaction partners:
Sequence:
MAPLAETHPASPPPELGADADKHEPQTPTRTLSPWPAQQWEPEQEEEVDPWELPELLDTGVKWSELDRRGKVLRVCTSVLKLLLLLGLLYMFVCSLDILSSAFQLVGGKAAGDIFKDNAVLSNPVAGLVIGVLVTVLVQSSSTSSSIVVSMVSSGLLEVKSAVPIIMGANIGTSVTNTIVAVMQAGDRNEFRRAFAGATVHDFFNWLSVLVLLPLEVASGMLYRLTKLVIDSFNIQTGADAPDLLKVITEPLTKNIIELDTSVIRDIATGDPAARNKSLIKIWCKTEKITNLVNVTVPGIANCTPDALCWVDGDLIWTQKNQTDTIYLKKCTHMFVFADLPDLAVGLILLALSLLALCTCLILIVKLLNSMLKGQVAVVIKKVLNTDFPFPFAWVTGYLAILVGAGMTFIVQSSSVFTSAITPLVGIGVISLERAYPLTLGSNIGTTTTAILAAMASPGETLANSLQISLCHFFFNIAGILLWYPIPFTRVPIRLAKALGNRTAKYRWFAGLYLILCFLLFPLTVLGLSIAGWQVLVGIGVPVLVLAIFVIVVNVMQKRCPRFLPSFIRSWEFLPKPLHSLKPWDRVVTAGMSFCRTRCCCCCKCCRNEEKNHMENNDRSLEMYDNPALGIEDEAKVTATHL