wanglab/gogpt-training-data huggingface dataset:
Protein: Flavin-dependent halogenase ascD (EC 1.14.99.-) (Ascofuranone/ascochlorin biosynthesis clusters protein D) (A0A455R7M0)
Organism: Acremonium egyptiacum (Oospora egyptiaca)
Function: Flavin-dependent halogenase; part of the asc-1 gene cluster that mediates the biosynthesis of both ascochlorin and ascofuranone, a strong inhibitor of cyanide-insensitive alternative oxidases and a promising drug candidate against African trypanosomiasis. The first step in the pathway is performed by the non-reducing polyketide synthase ascC that produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units. Orsellinic acid is then prenylated by the prenyltransferase ascA to yield ilicicolinic acid B. Ilicicolinic acid B is further reduced to ilicicolin B by the reductase ascB. The halogenase ascD then chlorinates ilicicolin B to produce ilicicolin A which is converted to ilicicolin A epoxide by the cytochrome P450 monooxygenase ascE that catalyzes stereoselective epoxidation of the terminal double bond of the prenyl group. Ilicicolin A epoxide is the last common precursor for the biosynthesis of ascofuranone and ascochlorin. The terpene cyclase ascF produces a monocyclic terpene, and the cyclization reaction is proposed to be initiated by protonation of the terminal epoxide of ilicicolin A epoxide to generate a monocyclic tertiarycation, which is followed by a series of hydride and methyl shifts with abstraction of proton, leading to the formation of the (14S,15R,19R)-trimethylcyclohexanone ring structure of ilicicolin C, which is finally reduced to ascochlorin by the dehydrogenase ascG. On the other hand, ilicicolin A epoxide is hydroxylated by the cytochrome P450 monooxygenase ascH, and the resultant product is cyclized by the terpene cyclase ascI to ascofuranol via protonation-initiated epoxide ring opening, which facilitates the 6-endo-tet cyclization to form the tetrahy-drofuran ring. Finally, ascofuranol is oxidized into ascofuranone by ascJ.
Interaction partners:
Sequence:
MSAIPKKCTVLVIGGGPGGSYAASALAREGIDTVVLEGDKFPRYHIGESMLASMRHLLKFVELDGKFDSYGFVKKPGAAFKLNKNKREGYTDFLAAGGPNNYAWNVVRSEADNLMFQHAGESGAKIFDGVSVKSIQFENPTEVPDGEPNLNPGKPVSATYQIKETKEQGQIDFDYVVDASGRIGILSTKYMKNRRYNQGLKNIANWGYWEGCNKYAPGTPRENSPFFEALQDESGWAWFIPLHNGTVSVGVVMNQKLATQKKQEADLDSTEFYHDTLNKISPNLRELIGDGKFVSNVKTASDYSYSASSYSFPYARIVGDAGCFIDPYFSSGVHLALTSGLSAATTISASIRGQVDEELGSEWHTKKFSDAYTRFLLVVLSAYKQIRHQEEPVLSDFDEDNFDRAFSFFRPIIQGTADAANNKLSQEELNKTLEFCAFAFEPVENDEDRSKAMSAMQEAVDNGTGYHPDLSPEQLKAVKHIQARRAMRTSDTMNIESFGTDAINGFVPNLVRGSLGLRKQEAMSGDMGGANGHVDETNGVTVNGHHQPEGVKAH
Protein: UDP-N-acetyl-D-mannosamine dehydrogenase (EC 1.1.1.336) (UDP-ManNAc 6-dehydrogenase) (P27829)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
Interaction partners:
- UDP-N-acetylglucosamine 2-epimerase
- dTDP-glucose 4,6-dehydratase 2
- dTDP-fucosamine acetyltransferase
- dTDP-4-amino-4,6-dideoxygalactose transaminase
- UDP-N-acetyl-D-mannosaminuronic acid transferase
- Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- ECA polysaccharide chain length modulation protein
- Glucose-1-phosphate thymidylyltransferase 2
- Lipid III flippase
- TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase
Sequence:
MSFATISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDTINRGEIHIVEPDLASVVKTAVEGGFLRASTTPVEADAWLIAVPTPFKGDHEPDMTYVESAARSIAPVLKKGALVILESTSPVGSTEKMAEWLAEMRPDLTFPQQVGEQADVNIAYCPERVLPGQVMVELIKNDRVIGGMTPVCSARASELYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICADQGINVWELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDHKPFWVIDQVKAAVADCLAATDKRASELKIACFGLAFKPNIDDLRESPAMEIAELIAQWHSGETLVVEPNIHQLPKKLTGLCTLAQLDEALATADVLVMLVDHSQFKVINGDNVHQQYVVDAKGVWR
Protein: Ubiquitin-conjugating enzyme E2-24 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 2) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) (P52485)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins.
Interaction partners:
- AT30415p
- E2 ubiquitin-conjugating enzyme
- glutaryl-CoA dehydrogenase
- Anaphase-promoting complex subunit 4
- E1 ubiquitin-activating enzyme
- Ubiquitin-ribosomal protein eS31 fusion protein
- Anaphase-promoting complex subunit 10
- Ubiquitin-ribosomal protein eL40 fusion protein
- Cell division cycle protein 27 homolog
- Cell division cycle 16
Sequence:
MSSTPAAGSAAEVATSSATSNAPSAPSTTASNVSNTSQPTTAGTPQARGGRGSNANGGASGSNAGGGDEPRKEAKTTPRISRALGTSAKRIQKELAEITLDPPPNCSAGPKGDNLYEWVSTILGPPGSVYEGGVFFLDIHFSPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLQNREEHDRIARLWTKRYAT
Protein: C2H2 finger domain protein, putative (AFU_orthologue AFUA_4G11480) (C8VG23)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
Sequence:
MAPGSGRDFSCPWDEPHCGKSFNRKSDLGRHYRIHTNERPYQCTYKDCHKSFIQRSALTVHSRTHTGEKPHVCDHEGCRKAFSDSSSLARHRRIHTGRRPYICQEPRCDKSFCRKTTLTKHQHRSHPLGSMARMPSEETVSEHSYSTPVTTSHPNEQYLLSQQAYYPNAPTPTHEFFPQQNLPMRPVTMQEHPPIIHSNIPVTSSVEVQHVQQFMQMMQQQQHQQHQQQHQQQQQQQQHPQQQNQGFDPHRMGFMPVEYQQPVYTAPTIESQPPMPYASTLEYKPPVMRLLNQPEGTDFAFLGTGC
Protein: Plasmid segregation protein ParM (ParA locus 36 kDa protein) (Protein StbA) (P11904)
Organism: Escherichia coli
Function: Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid.
Interaction partners:
Sequence:
MLVFIDDGSTNIKLQWQESDGTIKQHISPNSFKREWAVSFGDKKVFNYTLNGEQYSFDPISPDAVVTTNIAWQYSDVNVVAVHHALLTSGLPVSEVDIVCTLPLTEYYDRNNQPNTENIERKKANFRKKITLNGGDTFTIKDVKVMPESIPAGYEVLQELDELDSLLIIDLGGTTLDISQVMGKLSGISKIYGDSSLGVSLVTSAVKDALSLARTKGSSYLADDIIIHRKDNNYLKQRINDENKISIVTEAMNEALRKLEQRVLNTLNEFSGYTHVMVIGGGAELICDAVKKHTQIRDERFFKTNNSQYDLVNGMYLIGN
Protein: Methyl-CpG-binding domain protein 3b (A0A2R8QPC3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MEKNDRGEEEEEEQRRERGEAGRLYSLCPTGKKFRSKPQLARSLGNSMDLSSFDFRTGKMLMSKLNKNRQRPRYDNNSQSKGKPDLNTSLPVRQTASIFKQPVTKVTNHPSNKVKTDPQKAIDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDKTLLSAIASALHTSAAPITGQLSAAVEKNPGVWLNTAQPLCKAFIVTDEDIRKQEELVYSVRKRLEEALMADMLAHVEETASEGEALKQEGNCTDEKQEV
Protein: 2-oxoisovalerate dehydrogenase subunit beta (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta) (Q5SLR3)
Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Interaction partners:
Sequence:
MALMTMVQALNRALDEEMAKDPRVVVLGEDVGKRGGVFLVTEGLLQKYGPDRVMDTPLSEAAIVGAALGMAAHGLRPVAEIQFADYIFPGFDQLVSQVAKLRYRSGGQFTAPLVVRMPSGGGVRGGHHHSQSPEAHFVHTAGLKVVAVSTPYDAKGLLKAAIRDEDPVVFLEPKRLYRSVKEEVPEEDYTLPIGKAALRREGKDLTLIGYGTVMPEVLQAAAELAKAGVSAEVLDLRTLMPWDYEAVMNSVAKTGRVVLVSDAPRHASFVSEVAATIAEDLLDMLLAPPIRVTGFDTPYPYAQDKLYLPTVTRILNAAKRALDY
Protein: Uncharacterized protein C1F12.08 (Q10350)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Uncharacterized protein C14G10.01
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Probable thymidylate synthase
- Uncharacterized protein C4B3.18
Sequence:
MGKTLIFIKLSSLNECIKYSTIISKIARELSIHKGNELYIWVSCSEMCQKRTKHLFRELQNALCELYLSSATTNDSSLLSVVPTIVLFEYWSNIQLGSITDSWNSVYYSENAKDQILNIPAKSFQSIGPDVLNEIHNIEHLPKKDESEDSGKEINNMVSAVGGTFDHLHVGHKVLLTLTAWFGVKEVIVGVSGDELLKKKVQKEFLENIQKRKEEVSNFLHSIKEDINCRVVTIHDPFGPTITDAEIDSLIVSEETKTGATAVQEERVKRGLPELSIYCIDLLYPAQELNLKDNNSLKVSSTAIREELAKLAYKNK
Protein: Transcriptional regulatory protein BaeR (P69228)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Signal transduction histidine-protein kinase BaeS
- Multidrug resistance protein MdtB
- Multidrug resistance protein MdtA
- Multidrug resistance protein MdtC
- Sensor histidine kinase CpxA
- Putative multidrug resistance protein MdtD
- Periplasmic chaperone Spy
- Probable aminoglycoside efflux pump
- Sensor histidine kinase CusS
- Sensor protein BasS
Sequence:
MTELPIDENTPRILIVEDEPKLGQLLIDYLRAASYAPTLISHGDQVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDEGRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWEADACRIV
Protein: Homeobox protein ceh-8 (Q94398)
Organism: Caenorhabditis elegans
Function: Required for cell specification of the RIA interneurons.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Homeobox protein ceh-32
- Uncharacterized protein
- Conserved secreted protein
- Uncharacterized protein
- MX region of TRA-2 Related
Sequence:
MSNPTDNNSATSSITPNFSAFSSFTTYKPSDSFSSFESDSSPSKSSSSRKNRDKIADKKQRRNRTTFTTFQLHALEAAFDKTHYPDVYARETLAAKVQLPEVRVQVWFQNRRAKFRRQEKQDCQGEEKHSLKDTMPSWSWMSENKTDTPPMLPPANTLSSTHNNGISDEFFKTSEGKEVYGFPFAEYGTPADNTHVSKTGNVFHLNFEDSDKKSMKKESPQTPSTSSPFISEYHPPFIPYYIPNQSFSNAFNQYPMPFPYPIHFEPPQLTHSQENC
Protein: IP19021p (IP19215p) (IP19415p) (IP19521p) (Vitelline membrane 26Aac) (Q9VMK5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Vitelline membrane protein Vm32E
- Defective chorion protein, FC177 isoform
- Vitelline membrane protein Vm26Ab
- Vitelline membrane protein Vm26Aa
- Vitelline membrane protein Vm34Ca
- Protein palisade
- Vitelline membrane-like protein
- Follicle cell protein 3C-1
Sequence:
MWKYLGFFALLAGASSLGQQAGLEASTCGGSTGCLRSLPSRSSAVEPSDAYLNRRRRQQQIVQEVIVENNFGGPGFGGPGFGGPGFGGPGFGGPGFGGPGFGRPGFGGPGFGGPGFGGPGFGRGKFGFARSYDQDEAQVPVQGTYQQQTTLSEVPSPACPKNYVFSCEAVIKPVPCGYSSY
Protein: RNA polymerase II transcription elongation factor Rtf1p, putative (AFU_orthologue AFUA_2G01900) (Q5B4G0)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RNA polymerase II transcription elongation factor
- Paf1-domain-containing protein
- RNA polymerase-associated protein LEO1
- Pol II transcription elongation factor subunit Cdc73, putative
- FACT complex subunit pob3
- Transcription elongation factor spt5
- FACT complex subunit spt16
- Transcription elongation factor SPT4
- Transcription elongation factor spt6
- Meiotic recombination protein Ski8/Rec14, putative
Sequence:
MADDLDAELLALAGDDASSDEETSPPPRKHTSASPAQSASPRSPEPTSTMGRKGNAKPARRSRKSRRDDDEEEDGEISADSLNSASMSESEAPSDSESSDAGVEDEGPIYPYEKLYHSAQDKQEIMALPEIQREQILSERAQEVDRHNQDLALRRLLASREREEARKAKKNKRKASAANLDEGSRKSSRQKTTLGGRKVGEASEAIEAYKRQREQKGKRDELRRRDTATKDHKSKSRVSDEDADGESEVEWDDRERSPTPPKDDPPAELRDIQRARVGRTNFAQVCFYPGFEDTMVGCYVRLNVGPNPNGVNEYRLAMITEIKEGKKYALEGANGRTFTTDQYAVLAHGKTTRAFPFVACSDSPFTEAEFNRWRQVMAVEDCKMPTKSQLAKKVMDINRLINHQFTPEELNEKLRKQGLLDTKTTFFKRVDIEKKLKIAQELGDDDEVGRLQVELANLGSSAKPRTEKKLTEHERLAQLNLRNQKLNYENVRRAQIEERKASRKAAAAAARGEGSLNPFLRVKTRAKTHYDANESTPKSENGSPSVTPASSTPNPSTPARSSTPSNSQNKQSKGGGGKIRHRNMDDENIAALDLDIDIEI
Protein: Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) (O15146)
Organism: Homo sapiens (Human)
Function: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:23326516}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with acetylcholine receptors (AChR) to the postsynaptic cell membrane of the neuromuscular junction. {ECO:0000269|PubMed:23326516}.
Interaction partners:
- Low-density lipoprotein receptor-related protein 4
- Agrin
- Protein Dok-7
- 43 kDa receptor-associated protein of the synapse
- Acetylcholinesterase collagenic tail peptide
- Segment polarity protein dishevelled homolog DVL-1
- Nesprin-1
- Acetylcholinesterase
- Acetylcholine receptor subunit epsilon
- Utrophin
Sequence:
MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV
Protein: Uncharacterized protein (Q381M8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MIRKTLDVVPVVLPRHRIEEDARLAAEKRQRAADALTEQHHVVRYIIDSGEHSGDEEEEEESKKKDSGLRLFSVTSLPGSDVHSLKTLHILEAPRSAWGRATRSVYRGALRLPHLSGDDDEEEEEELRFSSLPLPGYEKKSCFLLTLPAIVDGDVGVADLKPLNTPIHALRCERAGTVKDGEGISSSWYSGVDTRKVQFKRSYIDDDYQDEGEDGGGYSSNDEKPRKRQDTKNLWDKGSEGSFGKRSKFESNGAVNRNDNESEVEMKNSTGGKTKMSASKTQESNNKGVATSEPPVSVLSTSALSETDEKSKSVGGPDLSGVNREDLKSLTDTFLKQWTNDGRSAVPFSEVARSVLKLHSLYTEMKAKHLSPQTRQEAVEWFRVSQASVRDNVVSLGYTMDNAGNVYLSRRSNA
Protein: TATA box binding protein (TBP)-associated factor, RNA polymerase I, A (TATA box-binding protein-associated factor RNA polymerase I subunit A) (Q1JQ67)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDDIEAELNIAETHADFTQDESEHRQRLKRPVQLHCQVKDRGFFTGIYFLKCNRKCLELLREAMLHHRWQEAVGYFSSYIQTLEAKTYNSYQSVVAEILWRLGTEILHHLPNTSNEDFNALYEQLKNVGVLNFSKISLEHCYHLLLNGQMDEAKRQLSIAESWRYGRVSRSQSLSKTLITAYCGLLDYLIWNEKKSSVSENEELSSNHEMHSYFRQASVTLKDIISLPGIWDPFVLSYVNMLEFYKQEESALQALENYAYNKEFPSNPNAHVYLYQFLKRHDAPREKLISTLRILHSLVPSHELMLELCNLLLGTLERSDTEEALAVCMDLLEFSSWKTDIRAWDCLLTILKKIRKKKWQEIIQKEWKVRRSLWVPLHFRDFLSLKDWMDNHKLMMIIKKDCLRIINENMREYCRVAAIAEKEVLLQIRMKRKKKQHKIQTAITELTN
Protein: RE33866p (Q8SYU1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MFVVRRSASRLYPAGVQLAKMSGSQVGDLGSGAGKGGGGGGSIREAGGAFGKLEAAREEEYFYKKQREQLDRLKNDQIHQAEFHHQQIKEHEEAISATRSSSRTCTSER
Protein: Gametocyte-specific factor 1 (Protein FAM112B) (Q9DAN6)
Organism: Mus musculus (Mouse)
Function: Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17919994, ECO:0000269|PubMed:19735653}.
Interaction partners:
- Piwi-like protein 2
- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
Sequence:
MEDTYIDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVANKLATCPFNARHQVPRAEISHHISSCDDKSCIEQDVVNQTRNLGQETLAESTWQCPPCDEDWDKDLWEQTSTPFVWGTASFCGNNSPANNIVMEHKSNLASGMRVPKSLPYVLPWKNNGNAQ
Protein: Probable ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Q9P3U0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 14
- Polyubiquitin
- Ubiquitin thioesterase otu2
- Probable ubiquitin carboxyl-terminal hydrolase 3
- Putative ubiquitin thioesterase otu1
- Probable ubiquitin carboxyl-terminal hydrolase 12
- Probable ubiquitin carboxyl-terminal hydrolase 1
- Ubiquitin carboxyl-terminal hydrolase 15
- Probable ubiquitin carboxyl-terminal hydrolase 4
- Probable ubiquitin carboxyl-terminal hydrolase 7
Sequence:
MATVKNLRIGKSPNRLIQDLDVFDSPSAGWNDPWSPHSSRYHWQLHSNLGESAVFDENDFWCVCQKTRKHLHVKVRRDRGKPLIEEPEENYGIKDRIPVYYEEEELPEPHVTSPTKSEFATTSTCMKWSSKTTKSEIEVEWRDSYLDANCIKEIIDSRRPSFASLLTKKSSSHQGSSHSSQPSLFTTFTSLELFLRNVLVHNDQRAISAAPEGTFERHVGKGRQIQSLMKSLLFEYHHENVNYVPTIADAPLTDEQKLNLYLARNELIVLANHFRDTKEDPAIVANPFPVRLARPALINAFGVPNYDSVVPMYTTVFRDNSASLPDDPAFIALGITNDYPDSFVRYFYEEQKKNDEANVRVYADALAHIYNLRKSSFLRDLIAADRKNGIVSSDVIQAAYSSLGLEAEVGPDYRYSQEKIFEAFHSALLRKPEFARAIRNDLETIGYARKSSEILNYVLSTEQAFYTVNEAYQWLGIKSNTEDAMVASVALVKFEDDSDKAIEAVKWIAEERNSSILYDFLASQGRPSNKKPKEVPMDEDLAYNTLGVQDRALSDDVLINVYGFAVEDHPEQSDTLRAALKCIGEVRNSRLITHYLEHGNLDIPPEVSSLDTPIGLENTGNLCYLNSLIQYYFIIKPLRNAILDIDENKDLNMIENKEAVKKVGGRIVTRIEFLRALQFTYELRKLFIELITSKSSSVHPSSVLTYLALIPLTLDQVKSGTSSVMDLSSSRELSNLNERSITIDPRAEEQAQGLEQEQGQDEAKSPAEQSSSVNLIDFPMANTNGESQTQPHYFEVSEEEINSSMDLGRQQDVLECIDHVLFQLEASLGRISNSEDRLGSDNDLIRRLFSGKLKQTLNDASQGVRSNYEIFSHLIVDLFEEKQTLYDALDGVFETVNIDMGSETAQRSLCITELPIILQLQIQRVQFDRTTGQPFKSNAFVEFGKELSMDRYVEDTDGKMAPLLQRYWDLKREIINLQKRQQLLLTTNSNLMSSVDTLSILSKWAAQQQDSRLPINPKLPDILQEEINNVVAEVDMLKKQEASLKEERTHLFDNYISHSYDLLAVFVHRGQASFGHYWTYIHDFENNVYRKYNDEYVTVVDESEIFADTTGNNANPYMLTYIRKEYRHIIECVHREHNLLL
Protein: Uncharacterized protein (Q57ZK6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- SET domain-containing protein
Sequence:
MDFDFVRMLQSSSCWHLCPTTDGKRTVFGTDDPNMKVPAPPLSPLRASAGSFTIRDETAPAPVEATRSGIQAAAAPPSPMQTIQMTPAGGAAYYVNPPAYQTVGMTSSPGHGHVPTQTVMLTPQNGRMVYMQMPYFQQTALQVPQPAQRVYPQPQGPYYSTHVVQMSPDGQIIQPVTSQGPYRVPQATPARGSASTAPTAGVVSQQNLQAAPQVEAFDQPSGGISIARGAQLPEGTPFIPYGVHPTRCYTNTQEKGVVSPRAGLHRAVWQVPTTTVPTTTLERPVGDGSAMMAKGHAITSADPF
Protein: UDP-glucuronosyltransferase 2B15 (UDPGT 2B15) (UGT2B15) (EC 2.4.1.17) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3) (P54855)
Organism: Homo sapiens (Human)
Function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:23288867}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Cytochrome P450 3A4)
- UDP-galactose translocator
- Cytochrome P450 2D6
- Cytochrome P450 3A5
- Cytochrome P450 2A6
- Cytochrome P450 2E1
- Cytochrome P450 1A1
- Aldo-keto reductase family 1 member C2
- Aldo-keto reductase family 1 member C3
- Aldo-keto reductase family 1 member C1
Sequence:
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD
Protein: mRNA export factor rsm1 (O94506)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the export of mRNA from the nucleus to the cytoplasm.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Armadillo repeat protein involved in nucleocytoplasmic transport Syo2
Sequence:
MSFPTDMETNEILDQLDKIDERNEDILLKSLKASKCTYKPWSREEFLRRLLTYRSRWAYVNDPQIGEINCCLNGWLCESNNILVCDVCRNKINLTALQQVDAENDSLNELPEKTKERLEVSLKEEHQDNCLWRLHKFPPDIYHLSVSAELVQVGRRFNSLSTRLVSTHLPEEMTLKRLEKVANKIRVDWEKEDAAVLLGIALTGWSEQVPGRLYVCNYCHRRLGVWNLQSEGQDFDVLEEHKKSCPWVIPQPFTDLLGWQQIFELLCKESIFQSTTKTMDVSQYTDYTFSLLQGLR
Protein: Phosphomevalonate kinase (PMKase) (hPMK) (EC 2.7.4.2) (Q15126)
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10191291, ECO:0000269|PubMed:27052676}.
Interaction partners:
- Diphosphomevalonate decarboxylase
- Mevalonate kinase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Farnesyl pyrophosphate synthase
- Isopentenyl-diphosphate Delta-isomerase 1
- Isopentenyl-diphosphate delta-isomerase 2
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Sterol regulatory element-binding protein 1
- Peroxisomal targeting signal 2 receptor
- Geranylgeranyl pyrophosphate synthase
Sequence:
MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL
Protein: EBNA1 binding protein 2 (H7C2Q8)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MYPEALPVGILSNPDTFKRRSGSYSNDKPEVWFAAGSGSPNQKLSSSCVGRACGEMDTPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQNKDQKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKVQTEVLQKRQQEKAHMMNAIKKYQKGFSDKLDFLEGDQKPLAQRKKAGAKGQQMRKGPSAKRRYKNQKFGFGGKKKGSKWNTRESYDDVSSFRAKTAHGRGLKRPGKKGSNKRPGKRTREKMKNRTH