wanglab/gogpt-training-data huggingface dataset:
Protein: ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1) (Q3TAS6)
Organism: Mus musculus (Mouse)
Function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.
Subcellular location: [Isoform 2]: Secreted {ECO:0000269|PubMed:28931551}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5UCC4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q5UCC4}.
Interaction partners:
- Endoplasmic reticulum membrane protein complex subunit 7
- ER membrane protein complex subunit 1
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 2
- ER membrane protein complex subunit 3
- ER membrane protein complex subunit 8
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 9
- ER membrane protein complex subunit 5
- Membrane magnesium transporter 2
Sequence:
MVAAGAGVTRLLVLLLMVAAAPSRARGSGCRVGASARGTGADGREAEGCGTVALLLEHSFELGDGANFQKRGLLLWNQQDGTLSATQRQLSEEERGRLRDVAAVNGLYRVRVPRRPGTLDGSEAGGHVSSFVPACSLVESHLSDQLTLHVDVAGNVVGLSVVVYPGGCRGSEVEDEDLELFNTSVQLRPPSTAPGPETAAFIERLEMEQAQKAKNPQEQKSFFAKYWMYIIPVVLFLMMSGAPDAGGQGGGGGGGSSR
Protein: Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD (EC 6.3.5.13) (Lipid II isoglutaminyl synthase glutaminase subunit) (EC 3.5.1.2) (A0A0H3JN63)
Organism: Staphylococcus aureus (strain N315)
Function: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.
Interaction partners:
Sequence:
MHELTIYHFMSDKLNLYSDIGNIIALRQRAKKRNIKVNVVEINETEGITFDECDIFFIGGGSDREQALATKELSKIKTPLKEAIEDGMPGLTICGGYQFLGKKYITPDGTELEGLGILDFYTESKTNRLTGDIVIESDTFGTIVGFENHGGRTYHDFGTLGHVTFGYGNNDEDKKEGIHYKNLLGTYLHGPILPKNYEITDYLLEKACERKGIPFEPKEIDNEAEIQAKQVLIDRANRQKKSR
Protein: Photosystem II reaction center Psb28 protein (F4JM05)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
Interaction partners:
Sequence:
MACVRSIGSLTSVNHSQRNVPRSGTRKNPNFALLIRRIGIVLSSCSVLPIKSSSFTGSPVSLPRAQPSSRTALRPMKPVSITMMVKPALQFIQGTDEMTIPDVKLTRSRDGSNGMALFSFDQPSVFDSSGEVGEITGLYMIDEEGVIQSTDVNARFVNGKPEGIVAKHIMRSPKEWDRFMRFMERYSDQNGLQFVKKQ
Protein: Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20) (Q6ZQN7)
Organism: Homo sapiens (Human)
Function: Mediates the transport of organic anions such as estrone 3-sulfate and thyroid hormones 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4). Capable of transporting pharmacological substances such as digoxin, ouabain, methotrexate and cAMP. Shows a pH-sensitive substrate specificity estrone 3-sulfate and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity).
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:30865704}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q71MB6}. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney. {ECO:0000250|UniProtKB:Q71MB6, ECO:0000269|PubMed:30865704}.
Interaction partners:
- Multidrug and toxin extrusion protein 1
- Organic anion transporter 3
Sequence:
MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTEITSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDVSFHKENAVVTNVLAEQDLNKIVKEG
Protein: Alport syndrome mental retardation midface hypoplasia and elliptocytosis chromosomal region protein 1 isoform 2 (Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region, gene 1) (A0A0S2Z4X0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAAGCCGVKKQKLSSSPPSGSGGGGGASSSSHCSGESQCRAGELGLGGAGTRLNGLGGLTGGGSGSGCTLSPPQGCGGGGGGIALSPPPSCGVGTLLSTPAAATSSSPSSSSAASSSSPGSRKMVVSAEMCCFCFDVLYCHLYGYQQPRTPRFTNEPYPLFVTWKIGRDKRLRGCIGTFSAMNLHSGLREYTLTSALKDSRFPPMTRDELPRLFCSVSLLTNFEDVCDYLDWEVGVHGIRIEFINEKGSKRTATYLPEVAKEQGWDHIQTIDSLLRKGGYKAPITNEFRKTIKLTRYRSEKMTLSYAEYLAHRQHHHFQNGIGHPLPPYNHYS
Protein: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 7.1.1.2) (Complex I-75kD) (CI-75kD) (P15690)
Organism: Bos taurus (Bovine)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:10852722, ECO:0000269|PubMed:18721790, ECO:0000269|PubMed:25209663}; Peripheral membrane protein {ECO:0000305|PubMed:25209663}; Matrix side {ECO:0000305|PubMed:25209663}.
Interaction partners:
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 3
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 alpha subcomplex subunit 2
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- Acyl carrier protein, mitochondrial
Sequence:
MLRIPVRKALVGLSKSSKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKTKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTHTTWEDALSRVAGMLQSFQGNDVAAIAGGLVDAEALIALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGSHPFSQVLQEAKKPMVILGSSALQRNDGAAILAAVSNIAQKIRTSSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIQKNPPKMLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDVEGANYFQQASELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAHAVEEPSIC
Protein: CUB-like domain-containing protein (Q9XUE0)
Organism: Caenorhabditis elegans
Interaction partners:
- Serine/threonine-protein phosphatase C23G10.1
- C-type lectin domain-containing protein
- ShKT domain-containing protein
- CUB_2 domain-containing protein
- Lysozyme-like protein 1
- CUB-like domain-containing protein
Sequence:
MLSKVVLFLAVLSSASASVCKTGNLINKPVNDSPVIWPATWDMKFAPPKLDKGQTCSWTVTVPDGFYAKLVISAKAMDRDTYFQTIDSAGNLAKTGNEKMKPYYFVGPKFTIALSSNAPAAFGFKIIWLPFPNIDIGYSGVTEAAEVLNATGIIYKQSIYSRGGIHLLPFPQDPTNYFSLRSALVFEGGSFPGCNYVGNLYQMYRSKKPYSFSSEGSIVVFNLAASGNSDKLLIQDTEYVQDIAQFVELYPEIKTSYTETINGGKLKSSLVSVSGANFKLTKVKMDDEATMAVYYGSPTVGTIVKNYTALEINKAVPLNFQGEVLQFVVSSGKADFTFDGWK
Protein: Aquaporin-8a.2 (Zgc:158752) (A1L2B1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MPVEAEKLELEELDKTLLNRDKPKPQSKYERIFQPCIAELVGTTFFVFIGCVSVIENVEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVVPYLISQLIGGVLGAAMSKVMTSDENYANATGAAFAVLKSDEQLGKVVFAEMAMTCLVTLVVLMGAVNGKSKSPMVPFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGLVAAALMRLLLGDEKLRVVMK
Protein: Dystroglycan 1 (C9JYS1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MRMSVGLSLLLPLSGRTFLLLLSVVMAQSHWPSEPSEAVRDWENQLEASMHSVLSDLHEAVPTVVGIPDGTAVVGRSFRVTIPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTLE
Protein: Procollagen C-endopeptidase enhancer 2 (Procollagen COOH-terminal proteinase enhancer 2) (PCPE-2) (Procollagen C-proteinase enhancer 2) (Q9UKZ9)
Organism: Homo sapiens (Human)
Function: Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Plastin-1
- Neurotensin receptor type 1
- Collagen alpha-1
Sequence:
MRGANAWAPLCLLLAAATQLSRQQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKKLPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARLTVVCKQCPLLRRGLNYIIMGQVGEDGRGKIMPNSFIMMFKTKNQKLLDALKNKQC
Protein: Terpene synthase 17 (ShTPS17) ((+)-valencene synthase TPS17) (EC 4.2.3.73) ((E)-beta-farnesene synthase TPS17) (EC 4.2.3.47) ((E)-beta-ocimene synthase TPS17) (EC 4.2.3.106) ((E)-gamma-bisabolene synthase TPS17) (EC 4.2.3.-) ((Z)-beta-ocimene synthase TPS17) (EC 4.2.3.-) ((Z)-gamma-bisabolene synthase TPS17) (EC 4.2.3.-) (Alpha-bergamotene synthase TPS17) (EC 4.2.3.54, EC 4.2.3.81) (Beta-bisabolene synthase TPS17) (EC 4.2.3.-) (Beta-myrcene synthase TPS17) (EC 4.2.3.15) (Gamma-gurjunene synthase TPS17) (EC 4.2.3.-) (Gamma-terpinene synthase TPS17) (EC 4.2.3.114) (Limonene synthase TPS17) (EC 4.2.3.-) (Terpinolene synthase TPS17) (EC 4.2.3.113) (G8H5N0)
Organism: Solanum habrochaites (Wild tomato) (Lycopersicon hirsutum)
Function: Sesquiterpene synthase involved in the biosynthesis of volatile compounds. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into gamma-gurjunene, (E)-beta-farnesene and (+)-valencene, and of (2Z,6Z)-farnesyl diphosphate ((ZZ)-FPP) into (E)-alpha-bergamotene and (Z)-gamma-bisabolene as well as beta-bisabolene, (Z)-alpha-bergamotene and (E)-gamma-bisabolene to a lower extent. Can act with a low efficiency as a monoterpene synthase with geranyl diphosphate (GPP) as substrate, thus producing beta-myrcene, (E)-beta-ocimene, limonene, terpinolene, gamma-terpinene and (Z)-beta-ocimene.
Interaction partners:
Sequence:
MELCTQTVAADHEVIITRRSGSHHPTLWGDHFLAYADLRGANEGEEKQNEDLKEEVRKMLVMAPSNSLEKLELINTIQCLGLAYHFQSEIDESLSYMYTHYEEYSIGDLHAIALCFRLLRQQGYYVSCDAFKKFTNDQGNFKEELVKDVEGMLSLYEAAQFRVHGEQILDEALNFTITKLKQILPKLSNSQLAQQITNALKFPIKDGIVRVETRKYISFYQQNQNHNQVLLNFAKLDFNILQTLHKKELSDMTRWWKKMELVNTLPYARDRLVECYFWCLGTYFEPQYSVARKMLTKISFFISIIDDTYDIYGKLDELTLFTQAIERWNIDASEQLPLYMKIIYRDLLDVYDEIEKELANENKSFLVNYSINEMKKVVRGYFQEAKWYYGKKVPKMEQYMKNAISTSAYILLTTTSWLAMGNVATKDVFDWVATEPKLVVASCHIIRLLNDLVSHEEEQKRGNAASAVECYMNEYSVTQEEAHVKIRDIIENYWKDLNEEYFKVDMIIIPRVLLMCIINLTRVAEFIYKDEDAYTFSKNNLKDVISDILVDPII
Protein: Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) (Q6TFL4)
Organism: Homo sapiens (Human)
Function: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity).
Subcellular location: Perikaryon. Cell projection, axon {ECO:0000250|UniProtKB:Q56A24}. Cytoplasm {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27889062}. Cell junction, desmosome {ECO:0000269|PubMed:27889062}. Cell junction, adherens junction {ECO:0000269|PubMed:27889062}.
Interaction partners:
- Cullin-3
- E3 ubiquitin-protein ligase RBX1
- Glutamate receptor ionotropic, kainate 2
- Kelch-like protein 9
- Kelch-like ECH-associated protein 1
- Kelch-like protein 7
- Speckle-type POZ protein-like
- Speckle-type POZ protein
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
- CREB3 regulatory factor
Sequence:
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL
Protein: Collagen alpha-1(XXIII) chain (Q86Y22)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}.
Interaction partners:
- Furin
- Collagen alpha-1
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
- Procollagen galactosyltransferase 1
- Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
- Collagen alpha-1
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Sequence:
MGPGERAGGGGDAGKGNAAGGGGGGRSATTAGSRAVSALCLLLSVGSAAACLLLGVQAAALQGRVAALEEERELLRRAGPPGALDAWAEPHLERLLREKLDGLAKIRTAREAPSECVCPPGPPGRRGKPGRRGDPGPPGQSGRDGYPGPLGLDGKPGLPGPKGEKGAPGDFGPRGDQGQDGAAGPPGPPGPPGARGPPGDTGKDGPRGAQGPAGPKGEPGQDGEMGPKGPPGPKGEPGVPGKKGDDGTPSQPGPPGPKGEPGSMGPRGENGVDGAPGPKGEPGHRGTDGAAGPRGAPGLKGEQGDTVVIDYDGRILDALKGPPGPQGPPGPPGIPGAKGELGLPGAPGIDGEKGPKGQKGDPGEPGPAGLKGEAGEMGLSGLPGADGLKGEKGESASDSLQESLAQLIVEPGPPGPPGPPGPMGLQGIQGPKGLDGAKGEKGASGERGPSGLPGPVGPPGLIGLPGTKGEKGRPGEPGLDGFPGPRGEKGDRSERGEKGERGVPGRKGVKGQKGEPGPPGLDQPCPVGPDGLPVPGCWHK
Protein: Serine palmitoyltransferase 2 (SPT 2) (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (P40970)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic subunit of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.
Subcellular location: Cytoplasm. Endoplasmic reticulum. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Protein ORM2
- Serine palmitoyltransferase-regulating protein TSC3
- Serine palmitoyltransferase 1
- 3-ketodihydrosphingosine reductase TSC10
- Protein ORM1
- Phosphatidylinositol-3-phosphatase SAC1
- Serine/threonine-protein kinase TOR2
- Serine/threonine-protein kinase TOR1
- Ceramide synthase LAC1
- Sphingoid long chain base kinase 4
Sequence:
MSTPANYTRVPLCEPEELPDDIQKENEYGTLDSPGHLYQVKSRHGKPLPEPVVDTPPYYISLLTYLNYLILIILGHVHDFLGMTFQKNKHLDLLEHDGLAPWFSNFESFYVRRIKMRIDDCFSRPTTGVPGRFIRCIDRISHNINEYFTYSGAVYPCMNLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKEDALVFSMGYGTNANLFNAFLDKKCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGLEKLIREQIVLGQPKTNRPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHSIGAMGPTGRGVCEIFGVDPKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYSESMPAPVLAQTISSLQTISGEICPGQGTERLQRIAFNSRYLRLALQRLGFIVYGVADSPVIPLLLYCPSKMPAFSRMMLQRRIAVVVVAYPATPLIESRVRFCMSASLTKEDIDYLLRHVSEVGDKLNLKSNSGKSSYDGKRQRWDIEEVIRRTPEDCKDDKYFVN
Protein: Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (PHS II) (Prostaglandin H2 synthase 2) (Prostaglandin-endoperoxide synthase 2) (Q5RI06)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Microsome membrane {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004174}.
Interaction partners:
- Prostaglandin E synthase
- Prostacyclin synthase
- Lipocalin-type prostaglandin D synthase-like protein
- Prostaglandin-endoperoxide synthase 1.
- Prostaglandin E synthase 3
- Prostaglandin E synthase 2
- Prostaglandin-endoperoxide synthase 2a.
- Arachidonate 5-lipoxygenase b, tandem duplicate 2
- Prostamide/prostaglandin F synthase
- Arachidonate 5-lipoxygenase a
Sequence:
MKSSVLFIFLLLGFVVCTGANPCCSHPCQNRGVCTEMGSDAYECDCTRTGYYGQNCTTPEFLTWVKVSLKPSPNTVHYILTHFKSLWNIINNVSFLRNGIMRYVLTSRAHLIDSPPTFNADYGYKSWEAYSNLSYYTRTLPPVPRDCPTPMGVAGKKELPDVKMLAEKLLLRRKFIPDPQRTNLMFAFFAQHFTHQFFKSDMKKGPAFTTALNHGVDLAHIYGQNLDRQHKLRLFKDGKLRYQILDGEVYPPTVSEVQVDMHYPPHVPESRRFAVGHEAFGLVPGLMMYATIWLREHNRVCDILKQEHPDWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYYFKLKFDPELLFNERFQYQNRISSEFNTLYHWHPLMPDDFHIQDEVYNYQQFLFNTSILTDYGVNSLVESFNKQIAGRVAGGRNVAPAVLRVAIKSIENSRQMRYQSINAYRKRFNMKPYRSFEEMTGEKEMAAELEEMYGDVDAVELYAGLLVEKPRSNAIFGETMVEMGAPYSLKGLMGNPICSPEYWKPSTFGGKVGFEIVNSASLQNLVCNNVNGPCPMASFYVPNVKDSLPTTINASTSQSDRNVNPTVLLKERTSEL
Protein: Histidine rich calcium binding protein (A0A8I6AUL9)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MGFQEPWLYSCLLWATVAILLVPPVVTQELRGTGLGLGNWNNNAGIPGSSEDLSTEYGHHIHSHGAYQGEKDRHHREEDEDFSREYGHQVQDHRYPGHEVGEENVSEEVFRGHVRQLHGHHKPNSEDLGDSAESHFPRQQSHNREEEDGVVSGEDHRHIPRHDHHGNEEEDDDGEEEERVGVMENSDDKHQAHGHHSHSKERDGLHHAHSHRHQGHHDEDDDDEDGVSTEGEHQAHRYQDHDEEDDDDSDEESHAHRLQGQEDENDDEDGDSSENGHQTQDHQGHKEQDDDDDEEEEEEEEEEEEEEEEEEEEEEDDDDDSTEHRHRHQTQGHRKGKDEDESDEDDHVTRHGRRGHEDEDDDDDDDDDDDDDNDGGSTENVHQAHRHRGHEHEDDGDDSEEDYHHVPSHGHQSHQNEEEEDEAVSTEHWHQSPRHAHHDLGRENQEEATVKYSRHVASHRPQGHSAEEDSLEDSTNEVPGHHHHRVSRDGDEDISTEFGHKAPRHRLQDQDEWTRQGHGKSVQEDIGHQPLQPTGPGSGESRKEDDHSSQEGDEDLKQRQEAHSEEEEEEEEGHGLPMSLEDEEEEEKDKKESKGDRAAVSAPLSHHRKHDDDDDGDGDDDDDDNDDDDEILEENLLPFTIIPNPLAGREVAREGSSEEESREVTGKVPVWLLPGVLWEACEPGSGGTQMWKSTAEMIIS
Protein: Large ribosomal subunit protein bL36c (50S ribosomal protein L36, chloroplastic) (Q6ENE0)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Uncharacterized protein
- Large ribosomal subunit protein bL27c
- Large ribosomal subunit protein bL33c
- Small ribosomal subunit protein uS14c
- Elongation factor Tu
- Small ribosomal subunit protein uS12c
- Elongation factor Tu
- 50S ribosomal protein L31
- Ribosomal protein L30 ferredoxin-like fold domain-containing protein
- Ribosomal protein L30 ferredoxin-like fold domain-containing protein
Sequence:
MKIRASVRKICTKCRLIRRRGRIRVICSNPKHKQRQG
Protein: Transcriptional adapter (E1JIP2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR025024}.
Interaction partners:
Sequence:
MSFMNPVDMVDEDAADLQFPKVEPLGPQVKRFIHAHQNEHTRNSMVLYNPHTLHRYLEEMEEKTRDQNSSVPSATKDANRCATCRCSLTEPYIKCSECLDTLLCLQCFSRGKEAFSHRNNHAYIIVRDNIQVFADEPHWTARDERILLKTLRTHGYGNWEAVSQALDQRHEPAEVRRHYHDCYFGGIFERLLNLKHARDSYVPERMPYVFKMRSLDPPRHDDIASMQFRLSAGYRCARGDFDTPYDTSAESLLSIMVDHRGRDDDNEASESEFEREVTEELQLGLVRAYNNRLRERQRRYKIMRQHGLIMPNRTVSWISKYVHAFGSDASCMRFLGFMQICPDPIKFDMLLESLRYYRELHSQLHKLYDLREHGVRTLSGAKLYARLSKERQQAQRDYSRLKQTDAFDWQQLVQHYESNRSGDPGPLAINSKLYVMNTRRKASPIEIGDLPGYSKLDDGERKLCSVARLVPQSYLDYKNQLVTEQAKLGYLRLADARRLIKIDVNKTRQIYDFLLEHGHISRPPSYG
Protein: Angiopoietin-related protein 1 (Angiopoietin-like protein 1) (Q640P2)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Angiopoietin-like protein 8
Sequence:
MKAFVWTLSVLLFLLGSGHCKGGQLKIKKITQRRYPRATDGKEEAKKCSYTFLVPEQKITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSRQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVTITVLEEQCLRMFSRQDPHASPPLVQVVPRHSPNSHQYTPGLLGGNEIQRDPGYPRDVMPPPDLPTAPTKSPFKIPAVTFINEGPFKDCQQAKEAGHSASGIYMIKPENSNGLMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLDNIYKLSNQDNYKLMIELEDWSEKKVYAEYSSFRLEPESDYYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDTYTGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKHQDGIFWAEYRGGSYSLRAVQMMIKPID
Protein: 35kDa protease (Q9BMQ7)
Organism: Bombyx mori (Silk moth)
Interaction partners:
Sequence:
MAGKMAVAYLIGILYTVSLVQGNPVNAGSEAIIEDLRNTDRQSRIVAGWPAEDAQIPHQISLRMVSPVGGVSSCGGSIIHHEWVLTAAHCLANRINFVVRLGLTNLTRPDYLVETTHKFIHPRYIEILGGVQTDDIALVKLNHHIPYSRYIQPCRLQNSEQKNINYEGAIFTVSGYGRTDDPWNGGVASEILLWVHLRGITNEQCLTHYPNSRVIQEQTLCAAYYNDTAQSSCQGDSGGPLTIVDEDGQPTMVGVVSFGHRDGCNSPHPSAYVRPGHYHEWFYEVTGINFDWSSEDLKPIVLAEAQDDVIAAE
Protein: INADL protein (A5PKX9)
Organism: Homo sapiens (Human)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}.
Interaction partners:
Sequence:
MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSVIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQQKEIEQSKEAWEMHEFLTPRLQEMDEEREMLVDEEYELYQDPSPSMELYPLSHIQEATPVPSVNELHFGTQWLHDNEPSESQEARTGRTVYSQEAQPYGYCPENVMKENFVMESLPSVPSTEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPSLLIDLPVVAQRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPAWVTEQDSVSKKKKNHEG