wanglab/gogpt-training-data huggingface dataset:
Protein: Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog) (Q8C142)
Organism: Mus musculus (Mouse)
Function: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15166224}.
Interaction partners:
- Low-density lipoprotein receptor
- Low-density lipoprotein receptor-related protein 2
- AP-2 complex subunit beta
- Apolipoprotein B-100
- Disabled homolog 2
- Proprotein convertase subtilisin/kexin type 9
Sequence:
MDALKSAGRALIRSPSLAKQSWAGGRHRKLPENWTDTRETLLEGMVFSLKYLGMTLVERPKGEELSAAAVKRIVATAKASGKKLQKVTLKVSPRGIILTDSLTSQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNESLECHAFLCTKRKVAQAVTLTVAQAFKVAFEFWQVSKEEKEKREKANQEGGDVPGTRRDSTPSLKTLVATGNLLDLEEVAKAPLSTVSANTNNVDETPRPQVLGNNSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLSAQDIHYAQCLSPTDWDKPDSSGIDQDDDVFTF
Protein: Invariant surface glycoprotein (Q585R8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MASPSDSREILNTLGYGAALVVPAFVKLCLTMAVMALDDQQPAADTGYRYRNDLKLPAARALCRLKEHIEKVQERVDQLSKMVEGNKSLGRRAMELAEEVKSEAAKSARGLSTVLSTHCRNPDENHHLPFSQNCDRSVSPIEPPDHKLKEEITCDATVESGANSTRGPSSRDMNNLVRMWDEVKPTASKGADGNSYRSKQSYEAAASKCKIDGYSTMPCTVSEKHWRSSFVAATLKLRELEVVVEEATGQTVQEVESKPQGIPRGLELGLEEATAGPTVQFLLGNNHTVYDCGTLTELSRLVSILVAVQI
Protein: FERM domain containing kindlin 2 (G3V3J0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQALLDKAKINQGWLDSSRSLM
Protein: 48 related 2, isoform D (A0A0B4LH78)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Blistery, isoform A
- FI03680p)
- Serine/threonine-protein kinase par-1
Sequence:
MSRNQLPDSSSSPPISHLPFHNFDDDLINDLPSCIYAGQHQGGGATGGGGGSGGGGGSSGLRLSSNNLRHIQQHYMQHSGENLLDSSTNPMGVHNSGGGAPLMCNSPSASSSGGGCGNAGSATPGGAGGPNPGYGSVGAATASSYKMQRQAANVRERKRIQRSAPTGYTKCSINSAFDELRVHVPTFPYEKRLSKIDTLRLAIAYISLLREVLQTDYDPLTYVEKCLRGEIKADRANWNTSDLTARLSWINWENLGVHPGRRTLLTSLALSSEPMCGAHCGMP
Protein: BEL1-like homeodomain protein 1 (BEL1-like protein 1) (Protein EMBRYO SAC DEVELOPMENT ARREST 29) (Q9SJ56)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription repressor OFP5
- Homeobox protein knotted-1-like 3
- Transcription repressor OFP1
- Transcription repressor OFP4
- Transcription repressor OFP2
- Transcription repressor OFP15
- Transcription repressor OFP11
- Transcription repressor OFP8
- Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5
- Transcription repressor OFP10
Sequence:
MAAYFHGNPPEISAGSDGGLQTLILMNPTTYVQYTQQDNDSNNNNNSNNSNNNNTNTNTNNNNSSFVFLDSHAPQPNASQQFVGIPLSGHEAASITAADNISVLHGYPPRVQYSLYGSHQVDPTHQQAACETPRAQQGLSLTLSSQQQQQQQHHQQHQPIHVGFGSGHGEDIRVGSGSTGSGVTNGIANLVSSKYLKAAQELLDEVVNADSDDMNAKSQLFSSKKGSCGNDKPVGESSAGAGGEGSGGGAEAAGKRPVELGTAERQEIQMKKAKLSNMLHEVEQRYRQYHQQMQMVISSFEQAAGIGSAKSYTSLALKTISRQFRCLKEAIAGQIKAANKSLGEEDSVSGVGRFEGSRLKFVDHHLRQQRALQQLGMIQHPSNNAWRPQRGLPERAVSVLRAWLFEHFLHPYPKDSDKHMLAKQTGLTRSQVSNWFINARVRLWKPMVEEMYMEEMKEQAKNMGSMEKTPLDQSNEDSASKSTSNQEKSPMADTNYHMNPNHNGDLEGVTGMQGSPKRLRTSDETMMQPINADFSSNEKLTMKILEERQGIRSDGGYPFMGNFGQYQMDEMSRFDVVSDQELMAQRYSGNNNGVSLTLGLPHCDSLSSTHHQGFMQTHHGIPIGRRVKIGETEEYGPATINGGSSTTTAHSSAAAAAAYNGMNIQNQKRYVAQLLPDFVA
Protein: Squamosa promoter-binding-like protein 6 (Q94JW8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein NBR1 homolog
- E3 ubiquitin-protein ligase PRT1
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Topless-related protein 1
- Transcription factor TCP4
Sequence:
MDSWSYGRSVFMSNETLLPCDTFAKNRRFEQRLSNNDDVLISDMAGNSNGFSAVSITKVVPEEEDEENISSSSKFSSQELNRIDFKLRSFLDLGNDDDDTSSRGFALPSKKSRASNLCSQNPLCQVYGCSKDLSSSKDYHKRHRVCEAHSKTSVVIVNGLEQRFCQQCSRFHFLSEFDDGKRSCRRRLAGHNERRRKPAFYFLPGKRHKLLRTSQDVVGNKFLENSSLVLPESFPGSLLYRVIDEDDHRTSRLVSFKDEPTCSMFPTNEQNSSRTYESKPAIYSTEVSSIWDLHETAASRSTRALSLLSAQSQQHLSKFPNTTFSITQPNQNLNHSSSTDYHQMEQPLWIDPGKTNSAGSSSCKGKGTSTVDLLQLSSHLQRIEQQRNYTGDVKQEYNELYFPGS
Protein: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 7.1.1.2) (Complex I-75kD) (CI-75kD) (Q91VD9)
Organism: Mus musculus (Mouse)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Peripheral membrane protein {ECO:0000269|PubMed:38575788}; Matrix side {ECO:0000269|PubMed:38575788}.
Interaction partners:
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 3
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH-ubiquinone oxidoreductase chain 5
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 7
Sequence:
MLRIPIKRALIGLSNSPKGYVRTTGTAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNVIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQNFEGNAVAAIAGGLVDAEALVALKDLLNKVDSDNLCTEEIFPTEGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGRHSFCEVLKDAKKPMVVLGSSALQRDDGAAILVAVSNMVQKIRVTTGVAAEWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKMLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPMADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGITLPYDTLDQVRNRLEEVSPNLVRYDDIEETNYFQQASELAKLVNQEVLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC
Protein: Arginine kinase Met e 2 (AK) (EC 2.7.3.3) (allergen Met e 2) (B1PVZ9)
Organism: Metapenaeus ensis (Greasyback shrimp) (Penaeus ensis)
Function: Catalyzes the reversible transfer of high energy ATP gamma-phosphate group to L-arginine.
Interaction partners:
Sequence:
MADAAVIEKLEAGFKKLEAATDCKSLLKKYLTKEVFDKLKDKKTSLGATLLDVIQSGVENLDSGVGIYAPDAEAYTLFAPLFDPIIEDYHVGFKQTDKHPNKDFGDVNSFVNVDPEGKFVISTRVRCGRSMQGYPFNPCLTESQYKEMEAKVSSTLSSLEGELKGTYYPLTGMSKEVQQKLIDDHFLFKEGDRFLQAANACRYWPAGRGIYHNDNKTFLVWVNEEDHLRIISMQMGGDLGQVFRRLTSAVNEIEKRIPFSHHDRLGFLTFCPTNLGTTVRASVHIKLPKLAANREKLEEVAGKYNLQVRGTRGEHTEAEGGIYDISNKRRMGLTEFQAVKEMQDGILELIKIEKEMI
Protein: G-patch domain containing 3 (Q5JYG5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MRLEQRLRDGQEDGSVIERQVGTFERHTKGIGRKVMERQGWAEGQGLGCRCSGVPEALDSDGQHPRCKRGLGYHGEKLQPFGQLKRPRRNGLGLISTIYDEPLPQDQTESLLRRQPPTSMKFRTDMAF
Protein: Nucleoporin 62 (M0QX64)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSGFNFGGTGAPTGGFTFGTAKTATTTPATGFSFSTSGTGGFNFGAPFQPATSTPSTGLFSLATQTPATQTTGFTFGTATLASGGTGFSLGIGASKLNLSNTAATPAMANPSGFGLGSSNLTNAISSTVTSSQG
Protein: SUPPRESSOR OF GAMMA RESPONSE 1 (NAC domain-containing protein 8) (ANAC008) (Protein SOG1) (SUPPRESSOR OF GAMMA RADIATION 1) (Q6NQK2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor regulating the transcriptional activation response to gamma irradiation. Required for stem-cell death induced by UVB or by gamma irradiation. Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases. Involved in DNA damage response (DDR) system that regulates cell cycle arrest. Functional homolog of animal p53. Regulates SMR5 and SMR7 transcription. Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress.
Subcellular location: Nucleus {ECO:0000269|PubMed:23907539}.
Interaction partners:
- Serine/threonine-protein kinase ATR
- Wee1-like protein kinase
- Cyclin-dependent protein kinase inhibitor SMR7
- Cyclin-dependent protein kinase inhibitor SMR5
- Peroxidase 53
- Transcription factor MYB3R-3
- DNA repair protein RAD51 homolog 1
- Cyclin-dependent protein kinase inhibitor SMR4
- Protein CHROMATIN REMODELING 25
- Transcription factor MYB3R-5
Sequence:
MAGRSWLIDSNRIATKIMSASASSDPRQVVWKSNPSRHCPKCQHVIDNSDVVDDWPGLPRGVKFDPSDPEIIWHLLAKSGLSGLSSHPFIDEFIPTVNQDDGICYTHPKNLPGVKSDGTVSHFFHKAIKAYSTGTRKRRKIHDDDFGDVRWHKTGRTKPVVLDGVQRGCKKIMVLYGGKAVKTNWVMHQYHLGIEEDEKEGDYVVSKIFYQQPQQLVVKRGDKAEQEVSEDIFAAVTPTADPVTPKLATPEPRNAVRICSDSHIASDYVTPSDYVSAHEVSLAETSEVMCMEDEVQSIQPNHERPSSGPELEHGLENGAKEMLDDKEEQEKDRDNENQGEEDPTWFDSGSQFILNSQQLVEALSLCDDLLGSQDREENTNSGSLKDKQPCIADYAHLGPEDFKRDLEECQKIVLDPSNIELDTPPEFRLSQLEFGSQDSFLAWGTGKTD
Protein: Serine/threonine-protein phosphatase sitA (EC 3.1.3.16) (Q4WM22)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Protein phosphatase that acts as a modulator of pkcA/mpkA activity involved in the cell wall integrity pathway. Plays an important role in regulation of adhesion, cell wall integrity, biofilm formation, and virulence.
Interaction partners:
- TOR signalling pathway regulator
- Sit4-associated protein
- Cyclin dependent kinase inhibitor Pho81, putative
- Protein phosphatase PP2A regulatory subunit B
- Protein phosphotase 2a 65kd regulatory sububit
- Serine/threonine-protein phosphatase 2A activator 1
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
- Protein phosphatase 4 core regulatory subunit R2
- Serine/threonine-protein phosphatase 2A activator 2
Sequence:
MVDNKIPEPGPAKLKRNAGPDEWLEAAKDCKYLSEQHMKQLCEIVKEYMMEESNIQPVSTPVTICGDIHGQFYDLLELFRVSGGMPDGSEAEAPKTQSAVITSDDIEPPSTISDPKLRKKLRNTFAPEDGSEDSSASQRDRSSSSGSRDVELKRNFVFLGDYVDRGYFSLETLTLLLCLKAKYPDRVTLVRGNHESRQITQVYGFYEECFQKYGNASVWKACCQVFDFMTLGAIIDGRVLCVHGGLSPEIRTLDQVRVVARAQEIPHEGAFCDLVWSDPDDVETWAVSPRGAGWLFGDKVADEFCHVNDLTLIARAHQLVNEGYKYHFANQNVVTVWSAPNYCYRCGNLASVCEIGDDLKPTFKLFSAVSDDQRHVPVSRPGRSEYFL
Protein: Zinc transporter 1 (ZRT/IRT-like protein 1) (O81123)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates zinc uptake from the rhizosphere. May also transport copper and cadmium ions.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- ATP-dependent DNA helicase homolog MER3
- DNA mismatch repair protein MSH4
- DNA mismatch repair protein MSH5
- Crossover junction endonuclease MUS81
- Meiosis-specific protein ASY1
- TPR repeat-containing protein ZIP4
- DNA mismatch repair protein MLH1
- Synaptonemal complex protein 2
- DNA mismatch repair protein MLH3
- Synaptonemal complex protein 1
Sequence:
MSECGCFSATTMLRICVVLIICLHMCCASSDCTSHDDPVSQDEAEKATKLKLGSIALLLVAGGVGVSLPLIGKRIPALQPENDIFFMVKAFAAGVILCTGFVHILPDAFERLSSPCLEDTTAGKFPFAGFVAMLSAMGTLMIDTFATGYYKRQHFSNNHGSKQVNVVVDEEEHAGHVHIHTHASHGHTHGSTELIRRRIVSQVLEIGIVVHSVIIGISLGASQSIDTIKPLMAALSFHQFFEGLGLGGCISLADMKSKSTVLMATFFSVTAPLGIGIGLGMSSGLGYRKESKEAIMVEGMLNAASAGILIYMSLVDLLATDFMNPRLQSNLWLHLAAYLSLVLGAGSMSLLAIWA
Protein: Protein SPATA31F1 (Protein FAM205A) (Q6ZU69)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MLSPTFVLWEVGYPLYIYGSIFIVIVIIWQVKRSHHELSSEPKRSCCRCHQKVRQRARDAASTARRRSREEAEKPQKLLSIIKSQGWLPLERSVRRILCADPCCQICNSVALEIQQLLVGENNQISLTLSGPLQGSSCLEMLSTSSMSLDQSLEFHSWHTRELSLSSVTPTLSQLTDQKSLTQSAAQSTYADGIQDYWADHLQLGQEFQVPDVLRGPNTIASSRIEKPRAPLNQEEMTQSNPSLVQGNQGQHHLNSQVSLLSLNPETLNRMHPMALHMVLPAHLPFLSPEVLRLLEVHVKKWMHFQRWGLPRRVEESLRQLMPNPPLYYQPGNDQPVSFNLKNTPQVSLHRFETISLQTWCSCVAGQPIQTFWVSEWSTMNPEQRHHCQQTPNPMALALPSPALKALSGPHPQSGGQDNDSGSDLQQKYSQLFCGLPSLHSESLVATFMGSQGLPKIENVPKPPLKDPFLFNELSFPQLLPKTSPQSAPPSSPLSPNWMSPSDHQRAQINVPFLTLAEYEALEWHLLQRQLQLQWGWPAALQRSQHTQCLMQHEPCGKAQSPETTTASQTGKSISVLTRELLFFPEHARKLLEFHIQKQLIRHRWGLPQKIQQSIQLLLTSTDQQTVSSSSTALANVSIPQPVALEANGACDVLSPIAAPVSIPRPHLLTQVKAILQSHIDSKCGQIHQGKIPACVHRSWDCRISGVLAVAPFPCIPESQFLELQTASDPDLHHKVMPWMPTALDQQQQALPGTVTEHPKLLRVLSVEAIEKLETTLRHKHLAFLSGLPALYYVALPRALAPAVTSQSVITEMEPSPVEIPAEPLIQMVSFEEQCISLGPCPQGNNESCTDVAKEFQPAVPVKGTMETLPLESQTHPTSPHSLQTHILTKLNFHLRKKVLEIQWGIPIRARKSREQTVAAPENISTQKSLESLNHQGETLLQELPIPPDTLPAPNPEGVHLKEQLANDLKAVQQNQKQSNSKAVPQGSAHSVSKISQPSGDMTEAHMPCVQVEANVNKPSLEEPCGPEPQSPSKSKDPAHVPMLAGNREDPEETKAARDHREGDAGFGRSSTREERRPAEDQRPAGMLPNKTPRGSWRWSRSFHLADPCQHSPQHHPQLKLPQLPPRVPGEKESEKDLQDSQTKLTVILEPATIPENAQTVLPQASQGQPFLSQPTQAKPLQGQTLQGQVLHGLVMPVHAQKKPSLTESSFRNKIKCFLQHINPKTKGKGHEDSMFSAAAKVAKTRKENVAKSLAPAKSPVGRSKTEKPTGCSKAQSRPAQKLVGPAFLDGPQSLDDKLRLHSRQPGSASALGYPRHCPRHCPREACANKPGHPT
Protein: Coronin (Q7JVY0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSFRVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALNEPIVMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKRGCDVTTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLKGGYVSSSVNKSLPAKKAGNILNKPRGDSASSGATSSSAGGGNFASGNNNEASEGGPPAAVLSEKDLRTIQDEIRKLKAIIVKQENRIRALEAKEDARNKNGSDAAPASAGAATSDGKASESANDHASTSAGTSKDED
Protein: Hexuronate transporter (Aldohexuronate transport system) (P0AA78)
Organism: Escherichia coli (strain K12)
Function: Transport of aldohexuronates such as D-glucuronate and D-galacturonate. Under anaerobic conditions, can play a critical role as a D-glucose transporter in the absence of sugar-PTS system.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Exu regulon transcriptional regulator
- Uronate isomerase
- Altronate dehydratase
- Altronate oxidoreductase
- Uxu operon transcriptional regulator
- Mannonate dehydratase
- D-mannonate oxidoreductase
Sequence:
MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELNISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWAMAWLIFYKHPRDQKHLTDEERDYIINGQEAQHQVSTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCILGGYLPPLFQRWFGVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVLQNKPAIEVAQETHNDPAPQH
Protein: Maintenance of telomere capping protein 1 (P47018)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in telomere capping.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Cytoplasmic vesicle, COPI-coated vesicle {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Ubiquitin-like protein MDY2
- Golgi to ER traffic protein 4
- Uncharacterized protein YJL118W
- Protein FYV8
- Protein CASP
- ATPase GET3
- Cruciform DNA-recognizing protein 1
Sequence:
MSENKNSEAEDVFEFLDSLPEAKNGGKMVNTDVKGSQEGVKGGSNSVAGKTGNDGKKGDDDIFEFLEELEKSNLSLTDKKGVEKKAPSESVNNKAQDEKVEESKENKNSEQDAHGKEKEPQQQEKEEEEEEEEEEEEEEEETPLHDPIASISNWWSSSGSAKVSSIWNKTAEQASQIKNRLAQEQLDLTSKINTSTITEIARNLQKIVVGETEEVLRIHLVHDLVNYPSLQYNIESKFDQVLSSQVEGGIRIFVDEWGHPNNNGITPVEKKPSVADGELGNSKKKLQFNLFDGKVTDGEKLAFANLENAVKLFNTAHEEYQKQQKEADATPDDDRSSISSNSNKISDLFISILPIAIPQKQKDADGDFQVTDSNTPGNFNFTLVLKDITNDITTITRSQGFPVKWVNWLEGSVEKTGSTASEERNKSYDQKKQKESEDEDEDDEIIDPSEWVKEWIEDGLSLSFGVMAQNYVIDRMGL
Protein: Ran BP2/NZF zinc finger-like superfamily protein (Q8GWD1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Cysteine/Histidine-rich C1 domain family protein
- RanBP2-type zinc finger protein At1g67325
- RNA-binding protein-like protein
- Zinc ion binding protein
- At1g11800/F25C20_3
- Transcription initiation factor TFIID subunit 15b
- Rhomboid-like protein 14, mitochondrial
- Zinc finger protein WIP4
- Probable E3 ubiquitin-protein ligase ARI15
- Probable E3 ubiquitin-protein ligase ARI13
Sequence:
MNRPGDWNCRLCSHLNFQRRDSCQRCREPRPGGISTDLLSGFGGRPVSSSFGFNTGPDVRPGDWYCNLGDCGTHNFANRSSCFKCGAAKDEFSCSSAAATTGFMDMNVGPRRGLFGFGGSSSGGGGTGRSPWKSGDWICPRSGCNEHNFASRSECFRCNAPKELATEPPY
Protein: U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) (Interacting with MPP10 protein 4) (P53941)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10409734}.
Interaction partners:
- ATP-dependent RNA helicase HAS1
- rRNA-processing protein FCF1
- Ribosome biogenesis protein ENP2
- NET1-associated nuclear protein 1
- 13 kDa ribonucleoprotein-associated protein
- Ribosomal RNA-processing protein 7
- Protein SOF1
- Periodic tryptophan protein 2
- U3 small nucleolar RNA-associated protein MPP10
- rRNA processing protein RCL1
Sequence:
MLRRQARERREYLYRKAQELQDSQLQQKRQIIKQALAQGKPLPKELAEDESLQKDFRYDQSLKESEEADDLQVDDEYAATSGIMDPRIIVTTSRDPSTRLSQFAKEIKLLFPNAVRLNRGNYVMPNLVDACKKSGTTDLVVLHEHRGVPTSLTISHFPHGPTAQFSLHNVVMRHDIINAGNQSEVNPHLIFDNFTTALGKRVVCILKHLFNAGPKKDSERVITFANRGDFISVRQHVYVRTREGVEIAEVGPRFEMRLFELRLGTLENKDADVEWQLRRFIRTANKKDYL
Protein: Luteinizing hormone beta subunit (Q9DG92)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU004069}.
Interaction partners:
Sequence:
MLGLHVGTLISLLLCILLEPVEGSLMQPCQPINQTVSVEKEGCPTCLVIQTPICSGHCVTKEPVFKSPFSTVYQHVCTYRDVRYETIRLPDCPPWVDPHVTYPVALSCDCSLCNMDTSDCTIESLQPDFCITQRVLTDGDMW
Protein: Bud site selection protein 9 (P53226)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in positioning the proximal bud pole signal.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11514631, ECO:0000269|PubMed:20678480}; Multi-pass membrane protein {ECO:0000255}. Bud neck {ECO:0000269|PubMed:11514631}. Bud tip {ECO:0000269|PubMed:11514631, ECO:0000269|PubMed:15356260, ECO:0000269|PubMed:20678480, ECO:0000269|PubMed:21625000}. Note=Found at the birth scar and the necks of large-budded cells and the proximal poles of daughter cells. {ECO:0000269|PubMed:11514631, ECO:0000269|PubMed:20678480, ECO:0000269|PubMed:21625000}.
Interaction partners:
- Bud site selection protein RAX1
- Bud site selection protein 5
- Bud site selection protein RAX2
- Axial budding pattern protein 2
- Bud site selection protein 3
- Bud site selection protein 4
- Putative protease AXL1
- Ras-related protein RSR1
- Bud site selection protein 8
- Inhibitory regulator protein BUD2/CLA2
Sequence:
MTKITRDVSITTENSKSTSGSATASSASLPENDHPIFHQPRARIRSGSLFIEGSDSFPSSEVKSYNVYIDDSKYSEILKGDTNSSSTDGKQVFEDARDDNFHQESHRDLEDSILDLVRRDPEVAAFPLPPPNSNERNRNSSNGSSAETNLNGHSSSGTISTSVLLNMGSAEKHAGTTRGDHMESSSMKSFEKLGTRPSSLFYPPPEGTAPYQGPRATVSGNKSTRQTQGTYSFPSMRYGVDLVSPVEGAVDVAKSRVPNSTLNGTFPDKAFIPHEFQIPKKAWNRIPANKSTSLKTPRNHSLLIDILKPFEAADLANDQRSSSAVLKNTVHSNGQYNPTNETSGTRMQDQRQKNTNEIDLEKIPNPQVPLGIAMDTMRSPNQLHEKEYESNIEAGLASGVGKGDNSIKQHQYKKIPQEIDRDQQLSFQMETMPIQRIDSSSIRSFDSRIYGFSEIYSIPRVITTLCICLFVPPLFFFFSINGNNGVSNYRLMRMIMNYEHRIGLLKGFEWDIDVQWFRTLCFVLGCIEMLAIFASIGIGFGVGIIRE
Protein: Sensory histidine kinase/phosphatase NtrB (EC 2.7.13.3) (EC 3.1.3.-) (Nitrogen regulation protein NR(II)) (Nitrogen regulator II) (NRII) (P0AFB5)
Organism: Escherichia coli (strain K12)
Function: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:15157101}.
Interaction partners:
- Nitrogen regulatory protein P-II 1
- DNA-binding transcriptional regulator NtrC)
- Glutamine synthetase
- Nitrogen regulatory protein GlnK
- Ammonium transporter AmtB
- Bifunctional uridylyltransferase/uridylyl-removing enzyme
- RNA polymerase sigma-54 factor
- Phosphate regulon transcriptional regulatory protein PhoB
- Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
- Nitrogen assimilation regulatory protein nac
Sequence:
MATGTQPDAGQILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMQESLEAGQGFTDNEVTLVIDGRSHILSVTAQRMPDGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEYTKVIIEQADRLRNLVDRLLGPQLPGTRVTESIHKVAERVVTLVSMELPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALGPEGGEIILRTRTAFQLTLHGERYRLAARIDVEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGHTEFSVYLPIRK
Protein: Disintegrin and metalloproteinase domain-containing protein 5 (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (tMDC II) (Q5BK84)
Organism: Rattus norvegicus (Rat)
Function: This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MKTPISSILKSNGLGIFLYRSFITSTAVSYTYDRQDVRHSQSLSSLKNCNYNGYVAGFPNSIVSLTVCSGLRGMIQFENVSYGIEPVETLSGFIHVIYENTNQQAKIPDLGENQTYSWSDELDYQFRSNMKKSGFAVLRPRYIKTDIVVDKKLFDYMGSDTRVVLQKVIQIIGFINTMFSKLKLTVLINSVEIWSKENRIDFPEAPENLLVQFLHWKHKYRPQHISYLLAFVEHPASTGALYPGNLCKPIYGAAIALYPKGLSLESYSVIVLQLLSIGIGLTYDNADSCHCTGDVCLMTPKAIYSGGVKDFSTCSLDDFKYLSTQDLECLQDLPMERQKKKPSRPRRICGNGILEMNEQCDCGTLKNCTHKKCCDPMSCRLKSKAVCGSGECCGQDCKVKPVNVLCRKSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQAFCYSGLCMTSNNQCMNLLGKYVRGASFACYEEFNSRNDRFGNCIRKFCSFENSLCGKLVCTWPFKRLLMKDNMSAAYGQIRDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTICGPDMFCLETQCKETRFLVDFQQCNTSRDCNDHGVCNNFNHCHCDKGYNPPYCESVKGQFGSIDDGHKYYIDEGKSAKQQNRGIHPKQQLQLILYITLPLIMIISAVFIKQSKLSRLCGRERSEGTSCITEDSVSNTKMTTNEGSTLH
Protein: Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (ACH1) (ACT) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (CTE-IIa) (CTE-IIb) (CTE-II) (LACH1) (Long chain acyl-CoA thioester hydrolase) (MTE-II) (Q64559)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:7906114}.
Interaction partners:
- Acyl-CoA thioesterase 1
- Acyl-coenzyme A thioesterase 2, mitochondrial
- Acyl-CoA thioesterase 5
- Acyl-CoA thioesterase 4
- Acyl-CoA thioesterase 5
- palmitoyl-CoA hydrolase
- Acyl-coenzyme A thioesterase THEM4
- Very-long-chain enoyl-CoA reductase
- Acyl-coenzyme A thioesterase 13
- Acyl-coenzyme A thioesterase 8
Sequence:
MKLLARTLYLWEVGRQVASWSLTSGQECLVLRETWWASMRAVRTRAVHHKPGHCIAMGRIMRPDDANVAGNVHGGTILKMIEEAGVIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVHVLSENILTGTKKLTNKATLWYVPLSLKNVDKVLEVPPIVYLRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPILNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDNSQKRYRAASAFFTYVSLNQEGKPLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHTEPQP