wanglab/gogpt-training-data huggingface dataset:
Protein: Protein phosphatase 1 regulatory inhibitor subunit 16B (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (bTIMAP) (Q95N27)
Organism: Bos taurus (Bovine)
Function: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of the PI3K/AKT signaling pathway (By similarity). Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity). Involved in the dephosphorylation of EEF1A1 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12055102}. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Nucleus {ECO:0000250|UniProtKB:Q96T49}. Cell projection {ECO:0000250|UniProtKB:Q96T49}. Note=Colocalizes with RPSA/LAMR1 in the cell membrane (By similarity). Localizes to the perinuclear region (PubMed:12055102). Colocalizes with PTEN at the tip of EC projections (By similarity). {ECO:0000250|UniProtKB:Q96T49, ECO:0000269|PubMed:12055102}.
Interaction partners:
- Hypothetical LOC508425
- Endonuclease III-like protein 1 lyase)
- Major facilitator superfamily domain-containing protein 12
Sequence:
MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRAAPEQQMISDIHCMIAAGQDLDWVDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQQRSASEDQRNSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPHSDMDMPVENGLRAPVSTYQYALCNGDVWKVHEVPDYSMAYGNPGVADATPSWSGYKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSGVSRTGEGSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPIEEMEEKVHGCCRIS
Protein: Lectin alpha chain [Cleaved into: Lectin beta chain; Lectin gamma chain] (P81517)
Organism: Cratylia argentea (Cratylia floribunda)
Function: D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production.
Interaction partners:
Sequence:
ADTIVAVELDTYPNTDIGDPNYQHIGINIKSIRSKATTRWNVQDGKVGTAHISYNSVAKRLSAIVSYPGGSSATVSYDVDLNNILPEWVRVGLSASTGLYKETNTILSWSFTSKLKTNSTADAQSLHFTFNQFSQNPKDLILQGDASTDSDGNLQLTRVSNGSPQSNSVGRALYYAPVHVWDKSAVVASFDATFTFLIKSTDSDIADGIAWFIANTDSSIPHGSGGRLLGLFPDAN
Protein: phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (A0A384MTT2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAALYRPGLRLNWHGLSPLGWPSCRSIQTLRVLSGDLGQLPTGIRDFVEHSARLCQPEGIHICDGTEAENTATLTLLEQQGLIRKLPKYNNCWLARTDPKDVARVESKTVIVTPSQRDTVPLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRTMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALGDGDFVKCLHSVGQPLTGQGEPVSQWPCNPEKTLIGHVPDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITSPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGFFGVAPGTSATTNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHPNSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRSESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEAGHFLWPGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLRAIDTTQLFSLPKDFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALERRVHKM
Protein: Acylglycerol kinase, mitochondrial (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) (E9PC15)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004637}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004637}. Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Interaction partners:
Sequence:
MENTDSDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHVEGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSPTQ
Protein: SH3 domain-binding protein 5 homolog (Protein parcase) (Q9V785)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Rab11
- Tyrosine-protein kinase Btk
Sequence:
MSSAEDGELDPQIQIELENLNSATDEINKLEIELEEANSTFRILLNESTRRLKVSSKKLGNCIEKARPYYEALDKAREAQIECQKAAVKFQRANEIHAAAKETVALAEQRFMSNSHEWQFDNAWQEMLNHATQKVMDAETQKADCHAEHQRLTKLFNAAEQKLQQLEDRFRRSINKSRPYFEEKQVCQDQLQTQKNRIQELQQQVAGAKSTYSTALRNLERISEDIHRQRGDFPTPPGPREPGVGAELNSPTSSALPSLPDFQLELEKCDYPSIAGSQMSLGAKTPQAAAETEDEEDACDYDETGAGELRGVVDERDLEALRQKVKILAVRPIEGGDGQQQNDVWEHELKATVDKLDHLMMLKETAKRQQTNRLKSTEQRPDSLGAEALKRHCDVVEVKVTSCATTASLPVTPHHQLNHLAPPTPIKKLQQQLAPLPSVNVSMRELPLLARLSNELLDRSSAAFGGVRKTLRRRSLE
Protein: Mitogen-activated protein kinase (EC 2.7.11.24) (Q7ZVK8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Mitogen-activated protein kinase kinase 1
- Dual specificity protein phosphatase
- Transcription factor Jun
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog
- Protein c-Fos
- Apoptosis regulator Bcl-2
- Transcriptional regulator Myc-A
- Dual specificity mitogen-activated protein kinase kinase 6
- Dual specificity mitogen-activated protein kinase kinase 2
Sequence:
MAESGSSAAAAGAAGSNSSAAGPGGAVAPGGPSGAAGSKPGLESVKGQNFDVGPRYTDLQYIGEGAYGMVCSAFDNVNKIRVAIKKISPFEHQTYCQRTLREIKILLRFHHENIIGINDILRARHIDYMRDVYIVQDLMETDLYKLLKTQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINMKARNYLQSLPQKPKIPWNKLFPKADNKALDLLDRMLTFNPLKRINVEQALAHPYLEQYYDPSDEPVAEEPFTFNMELDDLPKEKLKELIFEETARFQANYQGS
Protein: RNA-binding protein Musashi homolog 1 (Musashi-1) (Q61474)
Organism: Mus musculus (Mouse)
Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16554442}. Nucleus {ECO:0000269|PubMed:16554442}.
Interaction partners:
- DAZ-associated protein 1
- RNA-binding protein Musashi homolog 2
- Roundabout homolog 3
- Transcription factor SOX-2
- Zinc finger CCCH domain-containing protein 14
- Nestin
- Protein numb homolog
- Numb-like protein
Sequence:
METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKHYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERSPLPSAPVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHSLGGPLIATAFTNGYH
Protein: TNF receptor-associated factor 5 (RING finger protein 84) (O00463)
Organism: Homo sapiens (Human)
Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:15121867}. Cytoplasm, cytosol {ECO:0000269|PubMed:15121867}.
Interaction partners:
- Baculoviral IAP repeat-containing protein 2
- TNF receptor-associated factor 6
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Receptor-interacting serine/threonine-protein kinase 1
- Tumor necrosis factor receptor superfamily member 1A
- TNF receptor-associated factor 2
- TNF receptor-associated factor 3
- Baculoviral IAP repeat-containing protein 3
- Serine/threonine-protein kinase TBK1
- Tumor necrosis factor receptor superfamily member 3
Sequence:
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL
Protein: Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase) (P19099)
Organism: Homo sapiens (Human)
Function: A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone. Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21-hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P14137}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14137}.
Interaction partners:
- 11-beta-hydroxysteroid dehydrogenase type 2
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
- Steroid 21-hydroxylase
- Steroid 17-alpha-hydroxylase/17,20 lyase
- 17-beta-hydroxysteroid dehydrogenase type 3
- 11-beta-hydroxysteroid dehydrogenase 1
- Aromatase
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- Aldo-keto reductase family 1 member C3
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
Protein: Off-track2 (RE41180p) (Q7JXW8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Frizzled-2
- Stretchin-Mlck, isoform U
- Tweedlebeta
Sequence:
MGLNGRRRLLGCGLGFFCLIFCSYAAPASFEDVSISRGPKSSITIKEQSSLQLPCDYQLPDGYLQKSSVILRWRKDSKTLRQVELGRMDSTTSEPQLETMLREDSRVALSKDSGALQFTSVLASDAGQYQCQLVIDDSVAASSSSGVLLVIEQLKFVPQPTSKNLELGTLSKVHCKAQGTPAPQVKWMRETQLPLPVNVTDQNGTLIFNQVSNEQRGQYTCIASNSQGQITATVSINVVVAPKFSVPPEGPIEVAEAGTAVIHCQAIGEPKPTIQWDKDLTYLNENNTDPERFSLMENGTLEIRNVRPEDEGRYGCTIGSSAGLKREDVLLVLKSSKSASNSIVTRIIIVIICLAFLYFVLVLGLKVWYRYRRHLGKVQLEDGHVNGPTDGQEHDHHENEPCLTEANSSKNLKSKLRESTILEQESQVADDIV
Protein: Cell adhesion molecule L1-like (A0A8I5Y8T8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
TMELPLGGRGLILSLIFLLLKLSTAEIPLSVHQVPTIVKQSYVQVAFPFDEYFQIECEAKGNPEPKFSWTKDDKPFDLSDPRIIAFNNSGTFRIPNEGHISHFQGKYRCFASNRLGTAISEEIEFIVPGVPKFPKEKIEPIDVEEGDSIVLPCNPPKGHPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPKLRTIVQKMPMKLTVNSSNSIKQRKPKLLLPPAQIGSASSKTVLKGDTLLLECFAEGLPTPQIEWSKLGSELPKGRATIEIHEKTLKIENVSYQDRGNYRCTANNLLGKASHDFHVIVEEPPRWKKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGLPIENHPFPGDVMFPREISFTNLQPNHTAVYQCEASNIHGTILANANIDVVDVVPLIQTKNEENYETVVGYSAFLHCEYFASPKATVVWEVADETHPLEGGRYHTHENGTLEIERTTEEDAGSYSCWVDNTMGKAVITANLDIRNATKLRVFPKNPRIPKSHVLELYCESQCDSHLKHSLKLSWSKDGEAFEMNGTEDGRIVIDGANLTISNISGEDQGIYSCSAQTALDSTSGKTQVTVLGVPDPPRNLLLSERQNRSVRLSWEAGDDHNSKISEYIVEFEGNREEPGKWEELTRVRGEETDVVLPLAPYVRYQFRVTAVNEVGKSHSSQPSDHHETPPAAPDKNPHNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVSWKPQGAPEEWEEETVTNHTLRVMTPTVYAPYDVQVQAINQLGSGPEPQPVTLYSGEDYPSTAPVIHRVDVMNSTLVKVTWSSIPKETVHGLLRGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLEPFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPSFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYELGELNEINVTTPSKSSWHLSNLNATTKYKFYLKACTSRGCGKPISEEGATLGEGSKGIRKITEGVNVTQKSHPVEVLVPGAEHIVHLMTKNWGDNDSIFQDVIETRGREYAGLYDDISTQGWFIGLMCAIALLTLILLTVCFVKRNRGGKYSVKEKEDLHPDPEVQSAKDETFGEYSDSDEKPLKGSLRSLNRNMQPTESADSLVEYGEGDQSIFNEDGSFIGAYTGAKEKGSVESNGSSTATFPLRA
Protein: AP-2 complex subunit mu (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Clathrin-adaptor medium chain Apm2) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein) (P54672)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor.
Subcellular location: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Interaction partners:
- AP-2 complex subunit sigma
- AP-2 complex subunit alpha-2
- AP-1 complex subunit beta
- NECAP PHear domain-containing protein
- AP-4 complex subunit beta
- Clathrin heavy chain
- AP-3 complex subunit delta
- AP-1 complex subunit gamma
- Uncharacterized protein
- Rac guanine nucleotide exchange factor B
Sequence:
MISALFLMNGKGEVLISRIYRDDISRGVANAFRLEVIGSQETRSPVKLIGSTSFMYIKVGNIYIVGVSRQNVNACMVFEVLHQLVDIFKSYFDNLDEDSIRNNFVLVYELLDEILDFGYPQNCSTDVLKLYITQGQGKLKSLDKLKQDKISKITIQATGTTPWRTPDIKYKRNELYIDVVESVNLLMSAEGNILRADVSGQVMMKCFLSGMPECKFGMNDKVIMDREKSTNGGSAARSGARRANGIEIDDITFHQCVRLGKFDSDRTVSFIPPDGEFELMRYRTTEHINLPFKVIPIVREMGRTRLECSVTVKSNFSSKMFGANVKVIIPTPKNTAVCKIVVAAGKAKYMPEQDAIIWRIRRFPGDTEFTLRAEVELMASVNLDKKAWSRPPISMEFQVTMFTASGFSVRFLKVVEKSNYTPIKWVRYLTKAGTYQNRI
Protein: Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (L30) (P83732)
Organism: Rattus norvegicus (Rat)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P83731}.
Interaction partners:
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL18
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL14
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein eL32
Sequence:
MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQINWTVLYRRKHKKGQSEEIQKKRTRRAVKFQRAITGASLADIMAKRNQKPEVRKAQREQAIRAAKEAKKAKQASKKTAMAAAKAPTKAAPKQKIVKPVKVSAPRVGGKR
Protein: EZH inhibitory protein (K27M-like inhibitor of PRC2) (B1B0V2)
Organism: Mus musculus (Mouse)
Function: Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation at 'Lys-27' (H3K27me3). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (By similarity). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q86X51}. Cytoplasm {ECO:0000250|UniProtKB:Q86X51}.
Interaction partners:
Sequence:
MASSSSPERGLEALRDTDESEGEAPGPSGPRGRGGPSGAGSALRLRSLEAEMAAACVTSTAGEDLGTFSEPGSQHGDPEGGGGPDLELGHARPMMRSQRELGLTPKGGGKADQGGKGRKGGSGSPPHTKSSRKREQPNPNRSLMAQGAAGPPLPGARGSPAMPQPESSLSPRPDQSHHFDFPVGNLEAPGPTLRSSTSQGSGSTPVPEALRCAESSRAESDQSSPAGRELRQQASPRAPDDDDDGDGGPDPRGSGTPEGWVLRSGVVPFGRRSSASEVSPEEVRPEAQCTGWNLRPRPRSSASAVSPEARPKAQSAGRNLRPRPRSSASVVSPEARPKAQSAGRNLRPRPRSSASVVSPEARPEAQSAGRNLRPRATPRVPVAPSSTTRSSSDRGSSRAPRSRSRSRSCSTPRLGSDHQRSRKIKMRLDLQVDREPESEAEQEEQELESEPGPSSRPQASRSSSRFAVPGRSSLAAEDSPPRRPVRMRASSPSPPGRLYPLPKHYFEGVHSPSSSSSESSSVSSSHSPLNKAPDPGSSPPLSSLSGPNPFWLALIADLDNLDSSSPRVPGEEIEAAPHTREEEDKKCRG
Protein: Small ribosomal subunit protein uS14 (40S ribosomal protein S29) (Q6QAP6)
Organism: Sus scrofa (Pig)
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62273}. Cytoplasm {ECO:0000269|PubMed:24930395}. Rough endoplasmic reticulum {ECO:0000269|PubMed:24930395}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (PubMed:24930395). {ECO:0000250|UniProtKB:P62273, ECO:0000269|PubMed:24930395}.
Interaction partners:
- Small ribosomal subunit protein eS17
- 40S ribosomal protein S8
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein eL6
- 40S ribosomal protein S7
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein uS9
Sequence:
MGPQGFYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD
Protein: RapA guanosine triphosphatase-activating protein 1 (Q75J96)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Mediates the deactivation of rap1 and plays an important role in spatially and temporally regulating cell adhesion and chemotaxis by controlling attachment disassembly in the leading edge through the regulation of myosin II assembly and disassembly. Overexpression leads to defective chemotaxis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18039932}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18039932}. Note=Translocates to the cell cortex in response to chemoattractant stimulation and localizes to the leading edge of chemotaxing cells via an F-actin-dependent pathway. Cortical localization is negatively regulated by ctx.
Interaction partners:
Sequence:
MSIYHGIIGSSDHIQNIFPPPSPRKNISLSTNNISSLTTPKNFTAIVVTKPLSQSTTSTQEMMNTSDILFDIQQPLSPQHHSRQIQQQQHEKITPEEEERRSDELQKILLDTIPILIKGVETLGIEVEQICNGDSANEKRSNCQVLVDIQKTLREYPRGMGYRSKTIPSNIVGKPKLIAFRHSMDQLVWENISKLSILKDFVEFTLDFQKLCVIGISIRDAINSFVNNKCEYLIKGFEFNNTNSILSGINIHHHLNHQPGASTPRPSHSSSSSLSHSLSSSPMSQSLPSSLTSGGVSLLNTSDDAIVPSLSSGNDDSSGSSLSSSDANVISINISTVIQNGVRDEINNTSISALKKSQKQQPVVLSRAPKQVMESTRILVDTVVNRKCMYREEKASIYREMMNDRLTLLKEDPKKFKQQLLQQRRQKLTNSDQPHETDYNEDFNLNNNSTNNNNNIKKESNGSSVNSQTTTTTTTTNNNNNNISPQHSGTSGSPSDKENSPIFSPGYLSTSPPKSPPKSPEFLGVPIGKKAHLLGHARSFSADTHATKEAAANQHHHSHNNIGSVLSPPLSSQNERILRNYKLLSSSPSSSSSAVVTNPVSLTTQLQQQQQQQQQQQTTSQPTQPPPSEYQLLDLEWEEPIDSDFILPCKGYKIDSGNSKCQQVNYDELIVLYTDEDEYHYCDDFCSLEHFNFLGVNKNQPDNPMCISVVVQHDTNELLYIIRTGEKDEKYRLSLPYGKKEISSKDMLKMIKKSRFNQMSNFKLKEVKSDQNQQFIKQLIQFEAKNIHKTFKFGVLYCSENQGTDENELYSNSSTSDEFQEFLRILGDRVQLQGWTKYRGGLDIKDNTTGTHSIYKKWRDFEIMYHVAPMIPCRAADEQSVERKRHLGNDIVLIIYKEGNTKLFDPSIIKSNFNHIFAVVQKVDPIPNVDGAAVINLGNSFNNNNSSNNNNNNNNNNNNNNNSDSNLPTTNNLPIITNVNYKISIGCKEEVQNFGPAFPKNHIFSTSTGENLTDFLLTRLINGERATLKSPVFAQKLKRTRKEFLHSFITDFGSE
Protein: Nucleoporin NUP221, putative (Q8I398)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Importin subunit beta, putative
- Uncharacterized protein
- Ran-specific GTPase-activating protein 1, putative
- Protein transport protein SEC13
- Uncharacterized protein
- Acyl-CoA synthetase
- Aspartate aminotransferase
- Aldo-keto reductase, putative
- Aldehyde reductase, putative
- Nascent polypeptide-associated complex subunit beta
Sequence:
MFNQNFNNSNLNKGNFQDSNNLLKNKNMFMQNSSQNNNIFGTFNQNNNTNKSLFGNSNLQSNIGNTDNSLFGGSKIQQPNNALVNKSIFNLGGSSGTSTGLSGGKSIYDNMNSQSNLNTKNIFGSTNVSNNTQGNMGGNSLFMNANNQNNLNMKNIFGSSSGLNNQTSNLGNKSIFGGLQPSNQTTPSNNIFGNMSSNQTNSSNIFGNLSSTSQNKSNSIFGGLGTSTNQSTGGGLFGNTGATSQNKTGGIFGGLSSTNQASTSSTSMFGGLSSNQAKPTNSLFGGLSSGATSNTGTQQSGNLFGSASGIGQSKTVGGIFGNLSSTNQASTSSSNMFGGLSSNQAKPTSSLFGGLSSGTTTNTSTQQSGNLFGSATGLGQNKTGGGIFGTLPSANQTSTTSSNMFGGLSTNQAKPTSSLFGGMSSGTTGITTNTTAQSGNLFGGTGTSQNKTGNLFGALPGANQTSTTSNIFGGLSSAQSKPTSNIFGTMGTVSATTTAASTSSNIFGSTGGLNQSKPSTGNVFGSLQTMTQPGSTNMFGTTQGTSQGLTSTNMFSSSTVPGSSQNKFTNMFGTLSGTTGSTPMGTLTTPNSTTTATTGLTGTGVGGTSGTSNIFGNVSGGSSFGNLSANKNIFGSTGTGMTLSTASTSLSPSVGTSLGQNLGGAMTSTLNTNLTTPGFGQSGGSNIFGNLGGTVTSNIGSTITPTPSSSTLLGSTLTSGLSTTTDTASKNFLLGDKNALTISPLGGTSTLPTSSTNLTMQTGTGLTSSTPNILINDQPRVVSNLNLVNELKRDKESNLRSTDNFHGLHDELTITKKKESIFDKIYNDDIDNEEEEEEDEEGGSSGGLFYNYINLIINDNINNIQKSTLTLLNDHDSLMWDNFKSHIFKNFVDYLVNFKQKKNQKMIKGNVLDLDQHEFQILIWLYNVNSTKLNFIPFKSFYYLLLSETNLNYSKVLIGGSDKKILLDNFIEVNDHYYINSNNDIFKSQLNKYRNSSLHRDEYNSSLDIDSMYKQLLKDILNSLLNMNLSITKENIRKNTKTENLKNGNEGKGAGLEIKKKRVDEKKKKKPTRGKKKKRVAKYKSEVNEDSYENDDNDENVNDNDNDESVGDNDESVDDNDKSVDDNDQSDYNNDQSYDDNVENNINTRKMVRVPQFRYENILLNYLFGTLQHLHDKFYKIEISNYVSKDLNQIDEYFFDSKSNAIFSYCYNNFYKNEMDKENSTIHFFFYLVNIMFRCGNYVGLIQIIKLEEFIKNLNIDNYLYDFVILLIRILLLIYNKKNTMNIFENMKVDIDCSDIFKKKIHMSNIINFFHSIIYLCINNIYAYDLLCILFSDIFCKKGNMYTNRDKKIAMKNIFFYIRKKNVTINNNNNNNNNTSSSNHNNNYINHGASIFHSVSDDDLLADKNYIKEIRNRHMNYDYNNDKIMMNGSLRKNRRHANNSNKDGNIYYNDTINDSSNDDYGEDEADDGYNSRDHDKPNKKKKPFFFDMISNMLQKPKTVKGYENDFNNGMDINDEVNKGIYNLRKSTFSKNPNDIYLGVTNRHAFNFQYCNIETSIWIELCLFLSKNFNIYGSKFIDNFDIIDTDVLYCDEENVSHINDTKCRRERINKRIEVLFITISNYIISENKEYLYICSKLKVDEVMNNFLINDGKISEKLKGNINKVLKNNFLLYIKLFYYLLLVGNIYTTIVFLSCVSNNVQRILLVLSIFLHNNNIFENHLLNNIKMKTLQYLKFRNDHNSILDTSHDITDVQNSENKFNLILLSMSNVDLPFDHFVLRNNNINILLKITYLLNLKTNISIKLLKSIVQENQDVLLHESVIGHINNDGNIFYGKLHDFLFLFKNKIKIRKDIKCFFLMYYILYKQNVSNNILLKTRQNEMDDEYLYKSRNFKFVHNKNINTLNKISLDNSLISVHSSILYKISQFYAILAYFANQRKNYIISFICYYILKDEDSAINSLIRIYNDELIYYFHNNEKEYNYIRKCAFRFFHLAKNMWPSNVKLESIENKSYLILCILFMKKKLFEEAFVIFSTNLVPDNMLEKLSTADYYNIDLSSNFLMTLKELCTQNYRIDELVSKPALKAIIKFLNPIKDKLDPQIVESINYLDEINY
Protein: NPC intracellular cholesterol transporter 1 (G3V7K5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- NPC intracellular cholesterol transporter 2
- Oxysterol-binding protein
- Sterol regulatory element-binding protein 2
- Neutral amino acid transporter 9
- GTP-binding protein 1
- Pancreatic secretory granule membrane major glycoprotein GP2
- Sigma intracellular receptor 2
- Sterol regulatory element-binding protein 1
- Insulin-induced gene 1 protein
- GRAM domain containing 1B
Sequence:
MGAHHPALGLLLLLLLCPAQVFSQSCVWYGECGVAFGDKRYNCEYSGPPKPLPKDGYDLVQELCPGLFFGNVSLCCDVQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPETRENKTNVKELEYYVGRSFANAMYNACRDVEAPSSNEKALGLLCGRDARACNATNWIEYMFNKDNGQAPFTIIPVFSDLSVLGMEPMRNATKGCNESVDEVTGPCSCQDCSAVCGPKPQPPPPPVPWRILGLDAMYVIMWVAYMAFLVLFFGGLLAVWCHRRRYFVSEYTPIDSNIAFSSNSSDKGEASCCDPLGVAFDDCLRRMFTKWGAFCVRNPTCIIFFSLVFIAACSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNSSVHIYEPYPSGADVPFGPPLNKEILHQVLDLQIAIESITASYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDNQVGDDFFVYADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAWAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVLISYAVMFLYISLALGHIQSWNRVLVDSKISLGIAGILIVLSSVTCSLGIFSYIGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSFLGLDIKRQEKNRLDILCCVRGPDDGQESQASESYLFRFFKNAFAPFLLTDWLRPVVMAVFVGILSFSIAVVNKVEIGLDQSLSMPNDSYVIDYFKSLGQYLHSGPPVYFVLEEGYNYSSRRGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWIDDYFDWVSPQSSCCRLYNVTHQFCNASVIDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYSSAVNIMGDDTYIGATYFMTYHTILKTSADYIDALKKARLIASNITETMRSKGSDYRVFPYSVFYVFYEQYLTIIDDAIFNLSVSLGSIFLVTLVALGCELWSAVIMCLTIAMILVNMFGVMWLWGISLNAVSLVNLVMTCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKRHTTQERYKGTERERLLNF