wanglab/gogpt-training-data huggingface dataset:
Protein: GH08893p (Uncharacterized protein, isoform A) (Q8SWX6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Endoplasmic reticulum chaperone BiP
Sequence:
MLHIVSVVIIALSLGCAVGQDLRRVDDTELIQLLTGSSNVVVLFNKNNCQRCVEYENMVTKIRAQLEETLSAIVVQSVDSNLVSIYDPSKEPALVFFRRGIPILYHGEINDDEILDFFNDNLEPAVKELSDDNFEHLTQASSGATTGDWFIFFSSAECTVCQRLYAVWESVGGKLKRKLNIARMNSLESGISTATRLGVLEAPAFIFLRQGKMYKYSAKQYSPEAFVQFAEKGYTQSHPQPVPAIPSAVNEFLGPLQSYFAAENITSLATLSIFALVALLFVGKKVAKIFSSEPAKTKNKSK
Protein: Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (PXR1P) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) (O09012)
Organism: Mus musculus (Mouse)
Function: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P50542}. Peroxisome matrix {ECO:0000250|UniProtKB:P50542}. Note=Cycles between the cytosol and the peroxisome matrix (By similarity). Following binding to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, recruited to the docking complex, composed of PEX13 and PEX14, leading to translocation into the peroxisome matrix along with cargo proteins. Export and recycling to the cytosol is initiated by binding to the PEX2-PEX10-PEX12 ligase complex via its unstructured N-terminus that inserts into the ligase pore and emerges in the cytosol (By similarity). Cys-11 of PEX5 is then monoubiquitinated, promoting its extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex (By similarity). Extraction is accompanied by unfolding of the TPR repeats and release of bound cargo in the peroxisome matrix. The TPR repeats refold in the cytosol and ubiquitination is removed by deubiquitinating enzymes, resetting PEX5 for a subsequent import cycle (By similarity). {ECO:0000250|UniProtKB:A0A1L8FDW4, ECO:0000250|UniProtKB:P50542}.
Interaction partners:
- Peroxisomal membrane protein PEX14
- Peroxisomal targeting signal 2 receptor
- Peroxisomal membrane protein PEX13
- Sterol carrier protein 2
- Peroxisome assembly protein 12
- Peroxisomal ATPase PEX6
- Peroxisome biogenesis factor 10
- Next to BRCA1 gene 1 protein
- 2-hydroxyacyl-CoA lyase 1
- Serine-protein kinase ATM
Sequence:
MAMRELVEGECGGANPLMKLATHFTQDKALRQEGLRPGPWPPGASAAETVSKPLGVGTEDELVSEFLQDQNATLVSRAPQTFKMDDLLAEMQEIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVAQDYNETDWSQEFIAEVTDPLSVSPARWAEEYLEQSEEKLWLGDQEGSSTADRWYDEYHPEEDLQHTASDFVSKVDDPKLANSEFLKFVRQIGEGQVSLESAAGSGGAQAEQWAAEFIQQQGTSEAWVDQFTRPGNKIAALQVEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSASYDKGYQFEEENPLRDHPQPFEEGLHRLEEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNRTALMALAVSFTNESLQRQACETLRDWLRYSPAYAHLVAPGEEGATGAGPSKRILGSLLSDSLFLEVKDLFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLMWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSALLAMFGLPQ
Protein: Protein C2-DOMAIN ABA-RELATED 6 (Protein ENHANCED BENDING 1) (Q9S764)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Stimulates the GTPase/ATPase activities of Obg-like ATPases (By similarity). Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (By similarity). Prevents hypocotyl bending as well as gravitropic response under blue light conditions.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9FHP6}. Nucleus {ECO:0000250|UniProtKB:Q9FHP6}.
Interaction partners:
- Fe
- ADP-ribosylation factor GTPase-activating protein AGD3
- ADP-ribosylation factor GTPase-activating protein
- Defensin-like protein 54
- Dehydrodolichyl diphosphate synthase 6
Sequence:
MEKTEEEVEMKELVGLVRILVKRGIDLARRDALSSDPFVVITMGPQKLKSFTVKNNCNPEWNEELTLAIEDPNEPVKLMVYDKDTFTADDKMGDAQIDMKPFLDVHKLGLKELPHGKELKRIVPTRDNCLSEDSIIVSDNGKIVQDMILLLKNVECGKVEIQLEWLKNPGGSGL
Protein: Deoxyguanosine kinase (A0A8I5ZV32)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAAGRFLLRRLRASFRSQPRNALVDAPRARGMHDGGGPRRLCIEGNIAVGKSTFVKLLTKTHPEWQVATEPIATWQNVQAAGTQKDSTSRRLGNLLDMMYQEPARWSYTFQTLSFMSRLKVQLEPTPGRLLQADTSVRVFERSVYSDRYIFAKNLFENGSLSDVEWHIYQDWHSFLLQEFEDRLLLHGFIYLQASPQVCMERLCQRGREEEKGIELAYLKQLHGQHEDWFINKTTKLHFEALRHVPVLVLNISEDFSENAAKQEELMGQVSRAWLLLVPSAELSSSWSLCQALLLCTSNCISYSRTLRS
Protein: Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Phosphoglycerate mutase family member 5 homolog) (Serine/threonine-protein phosphatase Pgam5, mitochondrial) (Q9W173)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
Interaction partners:
- Uncharacterized protein, isoform B
- RE45833p
- Serine/threonine-protein phosphatase Pgam5, mitochondrial
Sequence:
MKYTALWRSVGAMSCGSLVTYFAIRLFDGLEPSMLSGGAQGGKGRAIEPLASGAWRHHWDLDKPQLQKVANGEESSALRHIILVRHGEYTRTPNGSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRCTLLPEGTPYPGDPPSKRSARSLDLAYQRDGPRIEAAFRRYFFRASPEQEHDSYLLIVGHSNVIRYLILRALQLPPAAWTRLNLNHGSITWLTVWPSGYVTLRCLGDSGFMPVTEITHRRPSPAKSGSN
Protein: MTOR-associated protein MEAK7 (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1) (A8K5C2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Lysosome {ECO:0000256|ARBA:ARBA00004371}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MGNSRSRVGRSFCSQFLPEEQAEIDQLFDALSSDKNSPNVSSKSFSLKALRNHVGEALPPEMVTRLYDGMRRVDLTGKAKGPSENVSQEQFTASMSHLLKGNSEEKSLMIMKMISATEGPVKAREVQKFTEDLVGSVVHVLSHRQELRGWTGKEAPGPNPRVQVLAAQLLSEMKLQDGKRLLGPQWLDYDCDRAVIEDWVFRVPHVAIFLSVVICKGFLVLCSSLDLTTLVPERQVDQGRGFESILDVLSVMYINAQLPREQRHRWRLLFSSELHGHSFSQLCGHITHRGPCVAVLEDHDKHVFGGFASCSWEVKPQFQGDNRCFLFSICPSMAVYTHTGYNDHYMYLNHGQQTIPNGLGMGGQHNYFGLWVDVDFGKGHSRAKPTCTTYNSPQLSAQENFQFDKMEVWAVGDPSEEQLAKGNKSILDADPEAQALLEISGHSRHSEGLREVPDDE
Protein: 2-methylisoborneol synthase (2-MIB synthase) (EC 4.2.3.118) (A4FG19)
Organism: Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Function: Catalyzes the cyclization of 2-methylgeranyl diphosphate (2-MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate.
Interaction partners:
- Geranyl diphosphate 2-C-methyltransferase
- Cyclic nucleotide-binding domain
- Terpene synthase
Sequence:
MIELIGHETPVPSQQQHTGGVRGTSACTPPGVGERTTVLYCPPPPPERPEVAAEINRRVVVWMQGLGLGGEDNVAGVYKHDPGRGITLCHPGSQDVERMTAAGKMIVAETAVDDYFCETNSRRDANDQTIGPNLSLAQSAIDAPRLTPDLQALWNKCRDDHPVLRAQHEAFGDLERISSPAQAQRVRHDIAQLYLGYNAENGWRLLNRLPPVWQYLANRQMNSFRPCLNLTDALDGYELAPQLYAHPLVQDCTARATLIATLYNDLASCEREIREHGLPFNLPAVIAAEERIALDEAFVRACEIHNELIQALEEATGHAASALADPALSRYLTGLWSWLAGSRHWHFTTARHRA
Protein: DEAD-box ATP-dependent RNA helicase 14 (EC 3.6.4.13) (Q8H136)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
Subcellular location: Nucleus {ECO:0000269|PubMed:19245862}.
Interaction partners:
- DExH-box ATP-dependent RNA helicase DExH10
- Thioredoxin-like protein YLS8
- THO complex subunit 4C
- Regulator of nonsense transcripts 1 homolog
- Pescadillo homolog
- AT3g07170/T1B9_17
- Uncharacterized protein At2g34160
- DExH-box ATP-dependent RNA helicase DExH15 chloroplastic
- Protein SEH1
- Pre-mRNA cleavage factor Im 25 kDa subunit 2
Sequence:
MAATAAASVVRYAPEDHTLPKPWKGLIDDRTGYLYFWNPETNVTQYEKPTPSLPPKFSPAVSVSSSVQVQQTDAYAPPKDDDKYSRGSERVSRFSEGGRSGPPYSNGAANGVGDSAYGAASTRVPLPSSAPASELSPEAYSRRHEITVSGGQVPPPLMSFEATGFPPELLREVLSAGFSAPTPIQAQSWPIAMQGRDIVAIAKTGSGKTLGYLIPGFLHLQRIRNDSRMGPTILVLSPTRELATQIQEEAVKFGRSSRISCTCLYGGAPKGPQLRDLERGADIVVATPGRLNDILEMRRISLRQISYLVLDEADRMLDMGFEPQIRKIVKEIPTKRQTLMYTATWPKGVRKIAADLLVNPAQVNIGNVDELVANKSITQHIEVVAPMEKQRRLEQILRSQEPGSKVIIFCSTKRMCDQLTRNLTRQFGAAAIHGDKSQPERDNVLNQFRSGRTPVLVATDVAARGLDVKDIRAVVNYDFPNGVEDYVHRIGRTGRAGATGQAFTFFGDQDSKHASDLIKILEGANQRVPPQIREMATRGGGGMNKFSRWGPPSGGRGRGGDSGYGGRGSFASRDSRSSNGWGRERERSRSPERFNRAPPPSSTGSPPRSFHETMMMKHR
Protein: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (GNT-I) (GlcNAc-T I) (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (G5EFK6)
Organism: Caenorhabditis elegans
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU368119}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU368119}.
Interaction partners:
- ILEI/PANDER domain-containing protein
- Alpha-mannosidase
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase mans-2
- alpha-1,2-Mannosidase
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- alpha-1,2-Mannosidase
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Alpha-
- Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
Sequence:
MHISSKITFIFVLIYFSWNFYIQNGFTNKAIVKEELRLLKEMDEAGSRLEKLLKVEKEHMERLSETMNRATRLRITPNSNNPNNWPHPIPVIVFSCNRPDSVRAHVEKLIMYRPSAQQFPITVSQDCDNESVKKEVEKFGNSVNYVKHPPGESVKIEIPTNLQKFKPYYYISRHYKLALNHIFSNSNNYSSVIITEDDLDIAPDFFSYFSNTRYLLEKDPSLWCVTAWNDNGKPENIDLKSNATLYRSDFFAGLGWMMTRKTWEELEPIWPNGFWDDWMREPVQRKQRQCIRPEISRTGMMKYGKEGTSKGQFFSDHLEKIKVNDLPVDFSQINLDYLQKNEFESRLSLDIRNAVPVDIDDITYPDWKPDYEGMKAIIYYTGRTDFVAKADRLSLMHDFKAGVPRTAYNGIVTCFYKGTRIFLVPDRSKVPGYDSSW
Protein: Uncharacterized protein Rv2229c (P9WLH3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Bifunctional protein Rv2228c
- GTP cyclohydrolase 1 type 2 homolog
- Histidinol-phosphate aminotransferase Rv2231c
- Uncharacterized SURF1-like protein Rv2235
- Low molecular weight protein-tyrosine phosphatase A
- Tyrosine-protein kinase PtkA
Sequence:
MKAGVAQQRSLLELAKLDAELTRIAHRATHLPQRAAYQQVQAEHNAANDRMAALRIAAEDLDGQVSRFESEIDAVRKRGDRDRSLLTSGATDAKQLADLQHELDSLQRRQASLEDALLEVLERREELQAQQTAESRALQALRADLAAAQQALDEALAEIDQARHQHSSQRDMLTATLDPELAGLYERQRAGGGPGAGRLQGHRCGACRIEIGRGELAQISAAAEDEVVRCPECGAILLRLEGFEE
Protein: Uncharacterized protein At5g39570 (Q9FKA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Classical AGP protein
- Probable pectinesterase/pectinesterase inhibitor 51
- F17A17.37 protein
- BIIDXI-like protein At5g11420
Sequence:
MPYYTRDDNDVDDFDEFDPTPYSGGYDITVIYGRPIPPSDETCYPLSSGVDDDFEYERPEFTQIHEPSAYGDEALNTEYSSYSRPKPRPAFRPDSGGGGHVQGERPNPGYGSESGYGRKPESEYGSGYGGQTEVEYGRRPEQSYGSGYGGRTETESEYGSGGGGRTEVEYGRRPESGLGSGYGGRSESEYERKPSYGRSEEQEEGYRKPSYGRSEEQEEGYRKPSYGRSEEQEEGYRKPSYGRSEEEQEEGYRKPSYGRSEEQEEGSYRKPSYGRSDDQVESYIKPSYGRSEEQEEGSYRKPSYGRSEEQEEGSYRKQPSYGRGNDDDDDEQRRNRSGSGDDEEGSYGRKKYGGNDSDEDEEKKKHRHKHHHQKRRDEDDE
Protein: Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase) (Q9ERD9)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P28776}.
Interaction partners:
- Tryptophan 2,3-dioxygenase
- Kynureninase
- Kynurenine formamidase
- Tryptophan 5-hydroxylase 1
- Tryptophan 5-hydroxylase 2
- Amine oxidase [flavin-containing] A
- Cytochrome P450 1A1
- Amine oxidase [flavin-containing] B
- Cytochrome P450 1B1
- Serotonin N-acetyltransferase
Sequence:
MPHSQISPAEGSRRILEEYHIDEDVGFALPHPLEELPDTYRPWILVARNLPKLIENGKLREEVEKLPTLRTEELRGHRLQRLAHLALGYITMAYVWNRGDDDIRKVLPRNLAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLMVEIAASPAIKAIPTVSSAVEHQDPKALEKALCSIAASLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKGNPKLPEGLLYEGVWDTPKKFSGGSAGQSSIFQSLDVLLGIKHDVGEGSAAEFLQEMREYMPPAHRNFLSSLESAPPVREFVILRRNEDLKEAYNECVNGLVSLRMFHLSIVDTYIVKPSKQKPMGGHKSEEPSNTENRGTGGTDVMNFLRSVKDTTKKALLSWP
Protein: Suppressor of fused homolog (Q9Z0P7)
Organism: Mus musculus (Mouse)
Function: Negative regulator in the hedgehog/smoothened signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (By similarity). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for normal embryonic development. Required for the proper formation of hair follicles and the control of epidermal differentiation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10531011, ECO:0000269|PubMed:16459298}. Nucleus {ECO:0000269|PubMed:10531011}.
Interaction partners:
- Zinc finger protein GLI1
- Zinc finger protein GLI2
- Transcriptional activator GLI3
- Kinesin-like protein KIF7
- Protein smoothened
- Serine/threonine-protein kinase 36
- Serine/threonine-protein kinase ULK3
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Protein patched homolog 1
Sequence:
MAELRPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVRTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDEEDSRSICLGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINSQRQNGLTHDRAPSRKDSLGSDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH
Protein: EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase) (Q96S44)
Organism: Homo sapiens (Human)
Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28805828}. Nucleus {ECO:0000269|PubMed:22912744, ECO:0000269|PubMed:27903914, ECO:0000269|PubMed:28805828}.
Interaction partners:
- EKC/KEOPS complex subunit TPRKB
- EKC/KEOPS complex subunit GON7
- EKC/KEOPS complex subunit LAGE3
- tRNA N6-adenosine threonylcarbamoyltransferase
- Cellular tumor antigen p53
- tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
- Threonylcarbamoyl-AMP synthase
- Nucleoporin Nup43
- Pyridoxal kinase
- Integrator complex assembly factor WDR73
Sequence:
MAAARATTPADGEEPAPEAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIKHRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSVTVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLDEVRLRGRKRSMVG
Protein: Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src) (P25020)
Organism: Rous sarcoma virus (strain H-19)
Function: This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro.
Interaction partners:
Sequence:
MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPDETAAPDAHRNPSRSFGTVATEPKLFWGFNTSDTVTSPQRAGALAGGVTTFVALYDYESWTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRKSETAKGAYCLSVSDFDNAKGPNVKHYKICKLYSGGFYITSRTQFGSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERAYRMPCPPECPESLHDLMCQCWRKDPEERPTFKYLQAQLLPACVLEVAE
Protein: Cytochrome b559 subunit alpha (PSII reaction center subunit V) (P0C370)
Organism: Oryza sativa subsp. japonica (Rice)
Function: This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00642}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00642}.
Interaction partners:
- Photosystem II CP47 reaction center protein
- Photosystem II protein D1
- Cytochrome b559 subunit beta
- Photosystem II CP43 reaction center protein
- Photosystem II D2 protein
- Photosystem II reaction center protein H
- Photosystem II reaction center protein K
- Photosystem II reaction center protein L
- Photosystem II reaction center protein J
- Cytochrome b6-f complex subunit 4
Sequence:
MSGSTGERSFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTESRQGIPLITDRFDSLEQLDEFSRSF
Protein: BP74 N-terminal domain-containing protein (Q55A71)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MKLLLVLLSLLLTFSLLVQSETAYFGLKTYGDHNDFIFKLTDSEKIKKARDILSGKESDEVHVMGRIKKRNESYNPHYSFIIDPDTVTFFNMAIEVCDATTNYVEDHLDEACGAFLPGCFWCPWSSKLTKEVKPLELN
Protein: 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (F1N3B8)
Organism: Bos taurus (Bovine)
Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (By similarity). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P29728}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P29728}.
Interaction partners:
- Interferon-induced GTP-binding protein Mx1
- Interferon-induced GTP-binding protein Mx2
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Signal transducer and activator of transcription
- Ubiquitin-like protein ISG15
- Interferon induced protein with tetratricopeptide repeats 1
- Ribonuclease L
- Interferon induced protein with tetratricopeptide repeats 2
- RNA helicase
- Interferon induced protein 44
Sequence:
MGSRESHLYEKPSEKLEEFIQNHLRPSEDCQKDIDQSVDTICEVLQEPCPSLTVTGVAKGGSYGRRTVLRGNSDGILVVFFGDLEQFQDQEKRQYELLSKIWAQMKHCESTWKLAAKMELQNTNRSSRVTIQLSTKQQSITFNVLPAFNALGLSEKSSLWSYRELKRSLDMVKARPGEFSVCFTELQEKFFSNYPSKLKDLILLVKHWFQKCQEKLINSSLLPPYALELLTVYAWEQGCGAEDFDMAEGVRTVLRLIEKQEQLCVYWTVNYNFGDEIVRNILLSQLQAPRPVILDPTDPTNNVSMDNTCWLQLKHEAQNWLRSLRQNESPGPSWNVLPASLYITPGHLLDKFVKDFLQPNQTFQDQIKKALKIICSFLEENCFRHSTTKIQVIQGGSTVKGTALKTGSDASLVVFANSLKSYTSPKNERYNIIKEIHEQLEACRQEKDFEVKFEISKWKPPWVLSFTLKSKVLNESVDFDVLPAFNALGELKSGSTPSPRTYTELIHLYKPSDVFLEGEFSACFTKLQRNFVRSLPLKLKDLIRLLKHWYCGCEKKLKQKGSLPPKYALELLSIYAWEKGSGAQDFDMAEGFRTVLELVIQYQHLCVFWTVNYSFDDEILRNFLLGQIRRTRPVILDPADPTGDVGGGHRWCWHLLAKEATEWLSSLCFKDKSGCPIQPWNVPKKRVQTPGSCGAGIYSMVNEMHLLRSHRFLD
Protein: Tyrosine-protein kinase (EC 2.7.10.2) (Q503P3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MTEPAADLPFFYGSISRSEAEEHLKLAGMGGGLFLLRQCLRSLGGYVLSMIWNLDFYHYSIEKQLNGTYCIAGGKPHCGPAELCEYYSKDPDGLVCTLRKPCLRSPETEIRKGVFDNLRDNMLREYVRHTWKLEGDAMEQAIISQAPQLEKLIATTAHEKMPWFHGKIPRQEGERRLYSGSQPDGKFLVRERDEMGTFALSVTYGKTVYHYQILRDKSGKIAMPEGTKFDTVWQLVEYLKMKPDGLVTVLREPCVNQNNAAPAPANAPRRSRGNGYTPPPMVPKPMGAEGSRPSLPMDHDGFTSPYDDPNELKKKTLFIKRDKLMIDEVELGSGNFGCVKKGVFKMESKQIDVAIKVLKNENEKSVRDEMMREAEIMHQLSDPFIVRMIGLCEAEALMLVMEMAPAGPLNKFLSGKKDQITTENIVMLMHQVSMGMKYLEGRNFVHRDLAARNVLLVNQQYAKISDFGLSKALGADDNYYKARTGGKWPLKWYAPECIHFHKFSSKSDVWSFGITMWEAFSFGGKPYKKMKGPEVITYIEGGSRLDCPAACPEAMYELMKECWTYKHEERLNFAKVEEKMRTFYYSIAKKIPDYLKTENGTPPK
Protein: Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) (P30098)
Organism: Cavia porcellus (Guinea pig)
Function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Tachykinin precursor 3
- Protachykinin-1
- Tachykinin precursor 4
- G protein subunit alpha 15
- Succinate dehydrogenase assembly factor 3
- Progonadoliberin-1
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit alpha
Sequence:
MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIYALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDELELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSKSTSTTASFVSSSHMSVEEGS