wanglab/gogpt-training-data huggingface dataset:
Protein: Uncharacterized protein (A0A1D8PQV0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Fgr39p
- ATPase expression protein 1
- Uncharacterized protein
Sequence:
MKYQQIPKSIRLLFDIYKQLSNKQNSVYHPQVGKYLSQTNDLNLIYQQWQILTNNRKKGDSIKNITERQFYSPSISFGDYELSSTKKLFIKPTKNHFSFITGLPLEDPIFSSKSHDKNRHGQFINNIENNLLSYYSPFTQYPQNSKSQLAYKYYLRKFDESIPIMIILKKKYQMFSIFSMNHWDKIYFDMKRQTRRQNILTNVDDLTIPSRRNMMKLSQRQFEFTSINRIDLFKLALGSYNYFKSLSNPTTIFSNKFNLNKNLQIAPWNGNEFTSQSYNNNNNNDDDDELIKMIDKNCRVEIRDQSTGDIISPDDSKLLEYVNKEKSYVKQLDQDEVMDYSQQIPYQLNFDKYYMLNILNFDSGDTRLSSFSRILNTATTTTTTTTGGGDKNSSNSDISPSDLEIVGVRLSLDNPQVNRMINEMSDIKLNNKDDDVFAYEDILKLVHTPKRNVLRSLMDILAVKGIIKVRQSADKRGLYLLP
Protein: 3-oxo-5-alpha-steroid 4-dehydrogenase (EC 1.3.1.22) (Q20344)
Organism: Caenorhabditis elegans
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Microsome membrane {ECO:0000256|ARBA:ARBA00004154}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004154}.
Interaction partners:
- Nucleolar complex protein 3 homolog
- Small ribosomal subunit protein uS17m
- RRM domain-containing protein
- Conserved oligomeric Golgi complex subunit 2
- Replication termination factor 2
- Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15
- Macro domain-containing protein
- Disintegrin and metalloproteinase domain-containing protein adm-2
Sequence:
MRETILMMAWAMIGTAFFVFFALKMGLTAGYGRYTNQAQWGINPKLAWFIQESPAFFIPFYFLFGGLSSTGRILNCIFLVHYFYRALIYPFRIRSTTKSPLLIVAAAVAFCTYNGTLQGVWNSYYQLEEELTYRHLIGSILYFSGMFINHKSDNILMTLRKPGETGYKIPTGFLYEYISCPNYFGEIMEWIGYAILGWNLPALAFAIFTFANIGPRAIAHHNWYKEKFPKYPPTRRALIPYIY
Protein: Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (SAPKK3) (P70236)
Organism: Mus musculus (Mouse)
Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Binds to microtubules. {ECO:0000250}.
Interaction partners:
- Mitogen-activated protein kinase kinase kinase 7
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase kinase kinase 5
- Mitogen-activated protein kinase 11
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 13
- Mitogen-activated protein kinase kinase kinase 4
- Dual specificity mitogen-activated protein kinase kinase 3
- Stress-activated protein kinase JNK
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Sequence:
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHESKAADVASFVKLILGD
Protein: Non-expressor of PR1 (Regulatory protein NPR1 (Nonexpresser of PR genes 1) (Noninducible immunity 1) (Nim1) (Salicylic acid insensitive 1) (Sai1)) (Q8L9W4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDTTIDGFADSYEISSTSFVATDNTDSSIVYLAAEQVLTGPDVSALQLLSNSFESVFDSPDDFYSDAKLVLSDGREVSFHRCVLSARSSFFKSALAAAKKEKDSNNTAAVKLELKEIAKDYEVGFDSVVTVLAYVYSSRVRPPPKGVSECADENCCHVACRPAVDFMLEVLYLAFIFRIPELVTLYQRHLLDVVDKVVIEDTLVILKLANICGKACMKLLDRCKEIIVKSNVDMVSLEKSLPEELVKEIIDRRKELGLEVPKVKKHVSNVHKALDSDDIELVKLLLKEDHTNLDDACALHFAVAYCNVKTATDLLKLDLADVNHRNPRGYTVLHVAAMRKEPQLILSLLEKGASASEATLEGRTALMIAKQATMAVECNNIPEQCKHSLKGRLCVEILEQEDKREPIPRDVPPSFAVAADELKMTLLDLENRVALAQRLFPTEAQAAMEIAEMKGTCEFIVTSLEPDRLTGTKRTSPGVKIAPFRILEEHQSRLKALSKTVELGKRFFPRCSAVLDQIMNCEDLTQLACGEDDTAEKRLQKKQRYMEIQETLKKAFSEDNLELGNSSLTDSTSSTSKSTGGKRSNRKFSHRRR
Protein: Gef2p (A0A1D8PS75)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MRSRFFGKVHDTFISIRIFYNDFTTIDWTKAYLKGNQFNYSIEKKQWIGDDSVNDGQAIPFLHRAYYTLGKWFLILIIAFFFSIIAFCIDKVEILLVGFKHGYCRSNWFASQISCCIDNPKKLNVFKSGYVTNNTCDNWVSWNKFFHEHWLNTMRFDFIIYVVLTILLAMFACLITLSTKITGGSIPEDQSNHGKEIHADDNENATNQGRSVSVKPRVIYTATGSGVPEVKTILSGFVIRRFLGTYTLIAKTVALVFAIASGMSLGKEGPYVHLATCVGNITSRFFPFIYENDFFEKQILSASASAGVALAFGSPLGGVLFILEEINNYLPSNQLFQIFFCAIISTLFLKFLNPYGTGKTVLFELEYFSDWSPMELIFFVVIGIMGGVFGASFIKFSQWWAKKFRSNKHIKTHPIFEVFLVAAVTGIISFWNPYTKQASAELVLDLATPCSGGELDRSLCPQTEKQLLNELASLLFAFVVKVFLTFITFGLKLPCGIYVPSMVCGALFGRIFALFIRWLEFLSRKSSSSSSAFSTLSLPAPPLEFGLLCSSAGPHCVDMGIYAMISAGAFMAGVTRMNITLVTILFELTSSYTYVLPISIAIAVANWSGGLLEKNSLYESLLISNDYPFMAPETEPIDPYVSAGDIINQDSVPTTRISRHIPPDRQLYIDVSDSGYVPVSTLESKLQMLADRCLLDGCIALIKNQLCVGLLFFSELEICLDQIRAFTLKHDVKEELYCNLFDDDDGDGGGVDNKSLSKSRAMHNDKVVKNILNQSLDYFNYGAINEDEYLEMKSSIDVLTNLTNFVDRVPMFINYDTELCFAHLIFDRIGNRVIVLIKDGKYYGVLHKKVLIDYLRRTE
Protein: Metal cation transporter P-type ATPase (EC 3.6.3.-) (A0A0H3LAI3)
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MVLLLESDPYHGLSDGEAAQRLERFGPNTLAVVTRASLLARILRQFHHPLIYVLLVAGTITAGLKEFVDAAVIFGVVVINAIVGFIQESKAEAALQGLRSMVHTHAKVVREGHEHTMPSEELVPGDLVLLAAGDKVPADLRLVRQTGLSVNESALTGESTPVHKDEVALPEGTPVADRRNIAYSGTLVTAGHGAGIVVATGAETELGEIHRLVGAAEVVATPLTAKLAWFSKFLTIAILGLAALTFGVGLLRRQDAVETFTAAIALAVGAIPEGLPTAVTITLAIGMARMAKRRAVIRRLPAVETLGSTTVICADKTGTLTENQMTVQSIWTPHGEIRATGTGYAPDVLLCDTDDAPVPVNANAALRWSLLAGACSNDAALVRDGTRWQIVGDPTEGAMLVVAAKAGFNPERLATTLPQVAAIPFSSERQYMATLHRDGTDHVVLAKGAVERMLDLCGTEMGADGALRPLDRATVLRATEMLTSRGLRVLATGMGAGAGTPDDFDENVIPGSLALTGLQAMSDPPRAAAASAVAACHSAGIAVKMITGDHAGTATAIATEVGLLDNTEPAAGSVLTGAELAALSADQYPEAVDTASVFARVSPEQKLRLVQALQARGHVVAMTGDGVNDAPALRQANIGVAMGRGGTEVAKDAADMVLTDDDFATIEAAVEEGRGVFDNLTKFITWTLPTNLGEGLVILAAIAVGVALPILPTQILWINMTTAIALGLMLAFEPKEAGIMTRPPRDPDQPLLTGWLVRRTLLVSTLLVASAWWLFAWELDNGAGLHEARTAALNLFVVVEAFYLFSCRSLTRSAWRLGMFANRWIILGVSAQAIAQFAITYLPAMNMVFDTAPIDIGVWVRIFAVATAITIVVATDTLLPRIRAQPP
Protein: Twinkle mtDNA helicase (EC 5.6.2.3) (Progressive external ophthalmoplegia 1 protein) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase) (Twinkle protein, mitochondrial) (Q96RR1)
Organism: Homo sapiens (Human)
Function: Mitochondrial helicase involved in mtDNA replication and repair. Might have a role in mtDNA repair. Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB. Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate. Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand. In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities.
Subcellular location: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:11431692, ECO:0000269|PubMed:18971204}. Mitochondrion inner membrane {ECO:0000303|PubMed:34950192}; Peripheral membrane protein {ECO:0000269|PubMed:34950192}. Note=Colocalizes with mtDNA in mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins associated with mtDNA, probably involved in mtDNA maintenance and expression (PubMed:11431692). Associates with phospholipid membranes via electrostatic binding (By similarity). Preferentially associates with membranes enriched with cardiolipin, a lipid abundant in the mitochondrial inner membrane (PubMed:34950192). ATPase and helicase activity is enhanced by binding to lipid membranes (PubMed:34950192). {ECO:0000250|UniProtKB:Q9VL76, ECO:0000269|PubMed:11431692, ECO:0000269|PubMed:34950192}.
Interaction partners:
- Single-stranded DNA-binding protein, mitochondrial
- DNA polymerase subunit gamma-1
- Transcription factor A, mitochondrial
- ADP/ATP translocase 1
- DNA polymerase subunit gamma-2
- Deoxyguanosine kinase, mitochondrial
- Mitochondrial inner membrane protein Mpv17
- Ribonucleoside-diphosphate reductase subunit M2 B
- DNA-directed RNA polymerase, mitochondrial
- Succinate--CoA ligase subunit beta, mitochondrial
Sequence:
MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEIRQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEGSWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMFGLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPRPSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQFRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTALPAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSGKTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNSEICSGQAPTPDQPDTSKRSK
Protein: Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) (Q9Y5Y4)
Organism: Homo sapiens (Human)
Function: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269|PubMed:17207480}.
Interaction partners:
- Natural cytotoxicity triggering receptor 3 ligand 1
- Prostaglandin D2 receptor
- Interleukin-4
- Interleukin-7 receptor subunit alpha
- Interleukin-5 receptor subunit alpha
- Prostaglandin E2 receptor EP3 subtype
- Interleukin-9
- Interleukin-5
- Interleukin-13
- Thymic stromal lymphopoietin
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
Protein: 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta) (P21953)
Organism: Homo sapiens (Human)
Function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Subcellular location: Mitochondrion matrix {ECO:0000303|PubMed:10745006}.
Interaction partners:
- 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
- Dihydrolipoyl dehydrogenase, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit alpha
- Branched-chain-amino-acid aminotransferase, mitochondrial
- Branched-chain-amino-acid aminotransferase, cytosolic
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
- Pyruvate dehydrogenase protein X component, mitochondrial
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Sequence:
MAVVAAAAGWLLRLRAAGAEGHWRRLPGAGLARGFLHPAATVEDAAQRRQVAHFTFQPDPEPREYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDVAFGGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAFDQIVNEAAKYRYRSGDLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRSPFQAKGLLLSCIEDKNPCIFFEPKILYRAAAEEVPIEPYNIPLSQAEVIQEGSDVTLVAWGTQVHVIREVASMAKEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPLTGGFASEISSTVQEECFLNLEAPISRVCGYDTPFPHIFEPFYIPDKWKCYDALRKMINY
Protein: Siderophore transporter (Q5A2T6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
- High-affinity iron permease
- Fth1p
- ferric-chelate reductase
- Hap43p
- Fre9p
- Ferric/cupric reductase transmembrane component 1
- Cu
- GPI-anchored hemophore PGA7
- Ferroxidase
- GPI-anchored hemophore RBT5
Sequence:
MTSYQSSNNHSSEEDKHLSGDEKTFSPSDIVEKAIVEEKSIGVEKAEILANQWKHTFWFKLLLGFSAFLCGYAYGLDSQTRYVYTAYATASWSEHSLLTTVNAITGVVAAASQPVYARLSDVLGRLELFIVAVLFYVVGTIIECQSPTINAYVAGAVLFQIGYSGIIIMLLFILSDFSSLRWRLFFTLCPSFPFIINTWISGNVTAAVGTRWKWGIGMWAFILPLSCIPLVCCMIHMRWLAGKTEEWRVFKQRKTKFQELGVAGFSKYLFWRLDVIGLLLLTVSLGCLLVPLTLAGGIKETWKKAHIIVPIVIGGVLIPVFLLWEGYGARDPIIPLHLMKDRGIWSVVSISLFFDFVFAVESNFLYTVLMVAVNESQSSATRIASLSSFVSVVTGFIFGLFVVYFRRLKGFVVFGCAMWMVAFGIMYHFRSQLHAHAGIIGGMCLMGFGTGFFSYPINVSAQSCVSHEHMAVISSALYTTYRIGYAVGSSVAGAIWSQMLYSRLVKYLGDSTLATSVYTDPYTFIAQYVWGTPEREAAVKAYGEVQRVLMSVCIAFVAPMIVSALFMRDHKLTNEQSLEDVEKQEEKDSLANFFGNFKKKRVAV
Protein: Mitogen-activated protein kinase HOG1 (MAP kinase HOG1) (EC 2.7.11.24) (High osmolarity glycerol response protein 1) (P32485)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription via the stress response element (STRE) in promoters of target genes. Upon osmotic shock, associates with the SKO1-SSN6-TUP1 complex, phosphorylates SKO1, and converts it into an activator that subsequently recruits Swi/Snf and SAGA complexes. Activates the SMP1 transcription factor and the RCK2 kinase, both also involved in the regulation of the expression of a subset of osmotic stress-related genes. Phosphorylation of HSL1 by HOG1 leads to a G2 arrest essential for cell survival at high osmolarity. Mediates also cell-cycle arrest in G1 phase by the dual targeting of SIC1. Regulates MFA2 ARE-mediated translation in response to carbon source. Targets RPD3 histone deacetylase to osmoresponsive promoters to induce gene expression on stress. Required for the Golgi apparatus localization of MNN1. Plays an essential role in maintaining water homeostasis, arsenite detoxification, copper-resistance, cold-resistance, hydrogen peroxide response, adaptation to citric acid stress, and repression of the mating pathway activity. Functions as an arsenic sensor and effector via direct binding to arsenic and subsequent phosphorylation of the ARR1 transcription factor.
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation. Arsenic-binding promotes the nuclear localization (PubMed:31772124). {ECO:0000269|PubMed:31772124}.
Interaction partners:
- Tyrosine-protein phosphatase 3
- MAP kinase kinase PBS2
- High-osmolarity-induced transcription protein 1
- CRE-binding bZIP protein SKO1
- Protein phosphatase 2C homolog 1
- Tyrosine-protein phosphatase 2
- Zinc finger protein MSN2
- Glycerol uptake/efflux facilitator protein
- Zinc finger protein MSN4
- High osmolarity signaling protein SHO1
Sequence:
MTTNEEFIRTQIFGTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPYSAPYHDPTDEPVADAKFDWHFNDADLPVDTWRVMMYSEILDFHKIGGSDGQIDISATFDDQVAAATAAAAQAQAQAQAQVQLNMAAHSHNGAGTTGNDHSDIAGGNKVSDHVAANDTITDYGNQAIQYANEFQQ
Protein: Iduronate 2-sulfatase (EC 3.1.6.-, EC 3.1.6.13) (Q9VZP8)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Alpha-L-iduronidase
- AT21479p
- Alpha-N-acetylglucosaminidase
Sequence:
MITARLLLSLMMPVLLDAAAPPRRPNVVMVIFDDLRPVIGAYGDTLASTPYLDNFARGSHIFTRVYSQQSLCAPSRNSLLTGRRPDTLHLYDFYSYWRTFTGNFTTLPQYFKEHGYYTYSCGKVFHPGLSSNNTDDYPLSWSAPAFRPRTEQFMNSPVCPDKEGILRKNLICPVELQTQPYKTLPDIESVAEALRFVGSRSRHSQEPFFLAMGFHKPHINFRFPRQFLSRFNLSQFYNYTEDSLKPPDMPAVAWNPYTDVRARDDFKHSNISFPYGPISPLQAAQIRQSYYASVSYVDDLFGKLIGGLDLDETVVVALGDHGWSLGEHAEWAKYSNFEVALRVPLIIRSPQFPVAQTKYYHGITELLDVFPTLVDLAGLPKLDKCQSSQELTCGEGKSLYHQLMGLGRADEHVALSQYPRPGMLPTKHPNSDKPKLRNIKIMGYSLRTDIYRYTMWVRFHAQNFSRDWHDVYGEELYDHRLDSGEELNLMPLPQFDDVRQRLRRRLMEMVGS
Protein: Cilia- and flagella-associated protein 157 (Q9VWA6)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Interaction partners:
Sequence:
MPPKVKKEKKDVNKVTQVDRTFYELTITDLNQKLARLRSHVTTVDESNITLTEKLKEVEADGVDVAAHLERTLAERNNSITELEERLVEITKVRDVENRVAQEKIGDLESKYKAMHDQLTSEIKLLNGKLNSLDEFRIQRDVLLAKFDEQEADLNEREKDHKEALYNMEQRAVVEKDALKKEVEQKLLQVSEDFTRSSEIRNAGYTRRLIRENIALQKEIDLLVMSQIKLQQAYTNQKSKHKEMEEQYSALDQIKNELVRNSVNKIKIIEGLTRNYEKLKAKYVEVLRYKKAYESLLQAEKCENVKQKDAAGKLRTLAKRMEILDLDNRNLEVVHAQHEIEITRLRGVIQEIKCTVRDAIVAEQAAKKFPERLVEANVDDPAMINEVREEAISLCKLKRSDLLSQLMSIVSSHSEELPKTPSIASIVSATSSLYAPGKMGFMPTRPKATPFDAFRSEVIEQEPDRTVPEDLQKQKMQDRLMTSLRGDENTIIDVEFGTTLYVSSSREDDLIEVEEEPLEEPEGSTSSMSVKKASSEGSVAPPETVPLAVSASSKDIKGAPSIGALDTLTATSKMTGVTNEDEGEEEGEEEDFDVQFVY
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (Q5A5R4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA topoisomerase
- Rad2 family nuclease
- DNA repair protein RAD51 homolog
- DNA repair and recombination protein RAD52
- DNA 3'-5' helicase
- Serine/threonine-protein kinase MEC1
- DNA-dependent ATPase
- Crossover junction endonuclease MUS81
- DNA replication ATP-dependent helicase/nuclease DNA2
- Replication protein A subunit
Sequence:
MINNLQEQVAWVKRTNPHITPQAVIDLIRKPFPKDKSAPIPQVPDSIPSSDKENIPISKSQRKVQSRLPLKTISANESTLQSTPTPVNKTRLPPETSDIIDLTHSPPKKRSPPQPSSPIQPTPKKQKLDDSVFRKLLGLHESKIKILEEKFLTSESTSISLDQKKELYKKLERQIELLDNEINALKSGLDDSTELSSSPDSPEFRVPITRPVRLEAARTIVESTENEEDDTEDHFGDQTMDGLLTPTQERMSQDDLNEMASFIDDRTFDITSQSSDGEFIAVESDTEINDIRLSPETATKYGIKYNSQVIGKARTEVSSPISRVPAIPEIDSSDSEPELPPIEEDEIEETTIPNLQSGPDSPIVIDDDDDDFLDFTTQLNKEREIDFIELDSDDDVQEEQWPKESNAPPAPAPTNPVLTIDSDDAFSDDDEDLKEYFTENRASKGSEPFMDEVHSILNNVFKLKSFRANQLEAVSATLSNKDVFVLMPTGGGKSLCYQLPALVKSGATKGTTVVISPLISLMQDQVQHLLAKNIKAGMFSSKGGNDDNKHTIHLFREGFLDIVYLSPERANKSNAMQTIMTKLYNNNQLARVVIDEAHCLSSWGHDFRPDYQGLGFFKDKFPKVPIMALTATANEKVQMDILHNLKMKDPVLLKQSFNRTNLFYEIKLKKSNCLLEIKDYILSRFSGKSGIIYCHSKQSCEHTSMKLNEYGLKTSFYHAGMSADKRFNIQKRWQENKIQVICATIAFGMGIDKPDVRFVIHLYLPRTLEGYYQETGRAGRDGNFSECVMYYCYKDARSLQNLIQRDEELSESGRESHLAKLRQVIQYCENTTDCRRKQVLQYFNETFDPANCHKQCDNCRDYNHVTSVEKDCTEYAKDIIKLVKSIQDEQVTVLYCQDVFRGLSHKKITEAGHHENEYHGKGQSLDKNDVERIFFYLLSQQCIVEYHVMHGGFATDYVKVGKNADVVLNGQKKIIISFSSRPGSASNSLGRTAANTGKPVEYQESFITARQMTTVDVPDSSFSQRCLQELREAREKASTECSISNSQIVGEVTLRDMSAKLPTNKKDFAKLEGIKKGQLEHFTHFKKILTSLAREKKKMANTSISTVVSDISSISTSTVSPYFQPSQQDQEILDTLRAASQPKPSKSSTQSSYTKKKGSKKFNKGRSGNYFKKAAPKSLANSHRNVMPM
Protein: Cell division protein FtsA (P28264)
Organism: Bacillus subtilis (strain 168)
Function: Cell division protein that is required for the assembly of the Z ring. May serve as a membrane anchor for the Z ring (By similarity). Binds and hydrolyzes ATP. Also involved in sporulation (Probable).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P0ABH0}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0ABH0}; Cytoplasmic side {ECO:0000250|UniProtKB:P0ABH0}. Note=Localizes to the Z ring in an FtsZ-dependent manner (PubMed:11298280). In sporulating cells, preferentially localizes to only one of the two potential polar division sites (PubMed:11298280). Targeted to the membrane through a conserved C-terminal amphipathic helix (By similarity). {ECO:0000250|UniProtKB:P0ABH0, ECO:0000269|PubMed:11298280}.
Interaction partners:
- Cell division protein FtsZ
- Probable peptidoglycan glycosyltransferase FtsW
- Septation ring formation regulator EzrA
- Cell division protein SepF
- Cell division protein DivIB
- Cell division protein ZapA
- DNA translocase SpoIIIE
- Cell division protein FtsX
- Cell division ATP-binding protein FtsE
- Penicillin-binding protein 2B
Sequence:
MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKKGSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEIQVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLITGSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAVFQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVTVIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGVMSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQEIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE
Protein: Uncharacterized globin-like protein YNL234W (P53857)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Uncharacterized protein YKR075C
- SWIRM domain-containing protein YOR338W
- Uncharacterized protein YLR407W
- Nucleolar protein 19
- Hexose transporter HXT8
- Uncharacterized protein YOR062C
Sequence:
MTGEKILHSQLLTNSDMSSGNVHHTKPMMYNVTLPSYNSSSIGPVDNLKINERPGSHDHSMRSEMSSKNSGSDFMPQSISRSEGSVYQVKIDRGDSPNTEGFDFKVNARDLLLLRMSWDILLREYLTPKELKVFQALLYSNKHITSTERPYLNTAPDGMISKTIDPTARPRKTKQRDNDNKVDTALFCSQFYDNLIAMDPLLEEYFPSLKHQAVSFCKVLDSAIDNLENVHVLDDYIVKLGKRHSRILGIKTVGFEVMGKAFMTTLQDRFGSFLTLELKNLWGQLYSYLANCMITAGKDPMEKIQPDFSYNGDSVVLNFSIPKLAMHDISTVNKLQMVKTKNATIPHNITQVPTNKIPTEILLDNSSTPIKSDRESTPPISPKGSGSTKPSIGSSTVVESNTKKNNYDEKIHLLQKTAQQKNCSIM
Protein: Probable mitochondrial saccharopine dehydrogenase-like oxidoreductase At5g39410 (SDH) (EC 1.-.-.-) (Q8LGI2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:14671022}.
Interaction partners:
Sequence:
MNPTQKPEPVYDMVILGASGFTGKYVVREALKFLQTPSSSPLKSLALAGRNPTRLTQSLEWAARPNPPPSSVAILTADTSDPDSLRRLCTQTKLILNCVGPFRIHGDPVVSACADSGCDYLDISGEPEFMERMEANYHDRAEETGSLIVSACGFDSIPAELGLLFNAKQWVSPSVPNQIEAYLSLESDKKIAGNFGTYESAVLGVANAEKLKELRRSRPRRPRPTICGPPAKGPTLENQKTIGLWALKLPSADAVVVRRTLTTLTEKPHGLPGINESPEQIQKREAFWSSIKPAHFGVKITSKSLFGIFRYVTLGVSLGLLSKFSFGRWLLLKFPSVFSLGWFQKKGPSEEEVESATFKMWFIGRGYSEESLASQGETKPDLEIITRISGPEIGYITTPITLVQCGLIVLGQRESLVKGGVYTPGIVFGSTDIQQRLEDNGISFELISKIKTQG