wanglab/gogpt-training-data huggingface dataset:
Protein: Collagen type I alpha 2 isoform 5 (A0A0S2Z3K0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPVCFK
Protein: Fructose-1,6-bisphosphatase class 1 (FBPase class 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1) (P0A993)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01855, ECO:0000305}.
Interaction partners:
- Glucose-6-phosphate isomerase
- ATP-dependent 6-phosphofructokinase isozyme 2
- ATP-dependent 6-phosphofructokinase isozyme 1
- Fructose-bisphosphate aldolase class 2
- Fructose-1,6-bisphosphatase 1 class 2
- Transketolase 1
- Transketolase 2
- Transaldolase B
- Fructose-1,6-bisphosphatase 2 class 2
- Transaldolase A
Sequence:
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGEVQQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA
Protein: Complement C1q subcomponent subunit B precursor (Zgc:91810) (Q6DBS9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
Sequence:
MLFALMSAHVVPQLAIMLLLVTSSMSETCAGNKGFPGTPGIPGVPGTDGKDGAKGEKGDPGENAVLMTGPKGDPGKPGLPGRPGVKGPEGPQGPPGPPGPKGQRGVLSGKVAPDQYFVFSYKKSQKLEKILQDKLVVFDVPLISGIDGVLDGEGYFDVTITGMYYISYQISFQQSACLKIQVGAEEKVKFCDSPKLISGTAASVVLKLNKGDKVSVQSIGESTVFSRDTDCTFTGFMLFPIK
Protein: FMRF-Like Peptide (FMRFamide-like peptide 8) (G5EGN5)
Organism: Caenorhabditis elegans
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- FMRF-Like Peptide
- FMRFamide-like neuropeptides 19
- FMRF-Like Peptide
- FMRFamide-like neuropeptides 1
- FMRFamide-like neuropeptides 9
- FMRFamide-like neuropeptides 6
- FMRFamide-like neuropeptides 5
- FMRF-Like Peptide
- Soluble guanylate cyclase gcy-36
- FMRFamide-like neuropeptides 13
Sequence:
MLSGVLFSIFVLAISANASCDVSALTTENEKELGLRICHLEAEMQVVQRALQEVMQQTDVTLYDQEVPVMNKRKNEFIRFGKRSDGMEKRKNEFIRFGKRKNEFIRFGRSDKGLGLDDNDVSSEFFGYTSDVFYL
Protein: Angiomotin-like protein 1 (junction-enriched and -associated protein) (JEAP) (Q9D4H4)
Organism: Mus musculus (Mouse)
Function: Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:11733531}.
Interaction partners:
- RAC-alpha serine/threonine-protein kinase
- Merlin
- Myc proto-oncogene protein
- InaD-like protein
- Multiple PDZ domain protein
- Signal transducer and activator of transcription 3
- Angiomotin
- Rho GTPase-activating protein 17
- DDB1- and CUL4-associated factor 1
- Angiomotin-like protein 2
Sequence:
MRRAKSRRGPCEPVLRAPPPICYSPSSPVQILEDPAYFYPDLQLYSGRHEASTLTVEASGGLRGKSVEDPLSSFHSPNFLRTPEVEMRGSEDVASGRVLQRLIQEQLRYGTPTENMNLLAIQHQATGSAGPAHATTNFSSTETLTQEDPQMVYQSARQEPQGQEHQGDNTVMEKQVRSTQPQQNNEELPTYEEAKAQSQFFRGQQQQQQQQQQQQQQQQQQGQGPLSHTYYMAGGTSQKSRTEGRPTVNRANSGQAHKDEALKELKQGHVRSLSERIMQLSLERNGAKQHLPSSGNGKSFKAGGEPSPAQPVCKALDPRGPPPEYPFKTKPMKSPVSKNQDHGLYYNDQHPGVLHEMVKPYPAPQPARTEVAVLRYQPPPEYGVTSRPCQLPFPSTVQQHSPMSSQTSSIGGTLHSVSLPLPLPISLAASQPLPASPNQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGCYDNADKLHKFEKELQSISEAYESLVKSTTKRESLDKAMRTKLEGEIRRLHDFNRDLRDRLETANRQLSSREYDGHEDKAAESHYVSQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELREKQAYVEKVEKLQQALTQLQSACEKRGQMERRLRTWLERELDALRTQQKHGTGPPVSLPECNAPALMELVREKEERILALEADMTKWEQKYLEESTIRHFAMSAAAAATAERDTTISNHSRNGSYGESSLEAHIWPEEEEVVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAGKTDSASLRPARSVPSIAAATGTHSRQTSLTSSQLTEEKKEEKTTWKGSIGFLLGKEHQGQASAPLLPTTPASALSLPASTTSASSTHAKTGSKDSSTQTDKSTELFWPSMASLPSRGRLSTAPSNSPILKHPAAKGAVEKQENSPGHGKASEHRGRVSNLLHKPEFPDGEMMEVLI
Protein: N-terminal acetyltransferase B complex catalytic subunit naa20 (NatB complex subunit naa20) (EC 2.3.1.254) (NatB Nalpha terminal acetyltransferase 3) (O74457)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn, Met-Gln or Met-Met.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- N-terminal acetyltransferase B complex subunit arm1
- Uncharacterized N-acetyltransferase C663.13c
- N-alpha-acetyltransferase 30
- N-terminal acetyltransferase A complex subunit nat1
- N-alpha-acetyltransferase 40
- N-alpha-acetyltransferase 35, NatC auxiliary subunit
- N-terminal acetyltransferase A complex catalytic subunit ard1
- N-terminal acetyltransferase A complex subunit-like protein C418.02
- N-alpha-acetyltransferase 38, NatC auxiliary subunit
Sequence:
MTDTRKFKATDLFSFNNINLDPLTETFNISFYLSYLNKWPSLCVVQESDLSDPTLMGYIMGKSEGTGKEWHTHVTAITVAPNSRRLGLARTMMDYLETVGNSENAFFVDLFVRASNALAIDFYKGLGYSVYRRVIGYYSNPHGKDEDSFDMRKPLSRDVNRESIRENGENFKCSPADVSF
Protein: Ubiquinone biosynthesis protein coq-4, mitochondrial (4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase) (EC 4.1.1.-) (Coenzyme Q biosynthesis protein 4) (P91428)
Organism: Caenorhabditis elegans
Function: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
Interaction partners:
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Atypical kinase coq-8, mitochondrial
- All trans-polyprenyl-diphosphate synthase PDSS1
- UDP-sugar transporter sqv-7
- DNL-type domain-containing protein
- Glycosyltransferase family 92 protein F13G3.3
- sulfite oxidase
Sequence:
MSAQKLYASHVPLAPLSRMLLGIGSAVTAISDPKRGDMVAAMGETTAIGPVLENIRKRMESDVVGKRLLLEKPRISNGTIDRKWLRQLPDGTLGKLYSNFLDRLNTSPDARPTVKYIDNLEHLYVMQRYRETHDFTHIALEQKTNMLGEVTVKYFEGIQYGLPMCVTGGIFGGARLLTKNRQELVDRNLPWVVEQATNARFFMAFDWENHFEKQLSEVQKELNITPLSVNM
Protein: Protocadherin beta 12 (A0PJT6)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MPGQRQVFFLTILLLFWKSDSEAIRYSMPEEKESGYLVANVAKDLGLRVEELATRGAQIHYRGNKELLQMDAETGNLFLKEKLDREALCGATEPCVLHFQIILENPVQFFQTELQLTDINDHSPEFSDTEMLLTIPENAQPGTVFPLKAAHDSDMGSNAVQNYTVNPNIHFHVVTLSRSDGRKYPELVLDRALDREEQPELTLTLTALDGGSPPRSGTTEVHIEVVDINDNAPQFIQSLYEVQVPENSPLNALVVMVSATDLDAGIYGNVAYSLFQGDGLSQPFVIDKITGEIRLTKELDFEVSHHYTIEIAATDGGGLSGKCTVVIQVLDVNDNAPELAIRKLTVPVPENSAETVVAVFSVSDSDSGDNGRIVCSIQNNIPFLLKPTFENYYTLVTEGPLDRESRAEYNITITVWDLGTPRLTTQHTITVQVADINDNAPAFTQTSYTLFVQENNSPALHIGTISATDSDSGSNAHITYSLLPPHDSQLALASLVSINSDNGQLFALRAMDYEMLQAFELHVDATDGGSPALSSQALVRVVVLDDNDNSPFVLYPMQNASAPCTELLPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDAPKHKLLLLVKDNGDPPRSASVTLHVLVVDGFSQPYLPLPEVARDSTQDDYDVLTLYLVVALASVSSLFLLSVLLFVGVRLCRRARAASLGDYSVPEGHFPSHLVDVSRAGTLSQSYQYEVCLNGGTGTNEFNFLKPLFPILPTQAAAEERENAVVRNSVEFY
Protein: Pyruvate kinase (EC 2.7.1.40) (Q9SQQ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- L-lactate dehydrogenase
- Cytosolic enolase 3
- Bifunctional enolase 2/transcriptional activator
- Enolase 1, chloroplastic
- D-lactate dehydrogenase [cytochrome], mitochondrial
- NADP-dependent glyceraldehyde-3-phosphate dehydrogenase])
- Inosine triphosphate pyrophosphatase
- Malate dehydrogenase 3, cytoplasmic
- Malate dehydrogenase 1, cytoplasmic
- Malate dehydrogenase 2, peroxisomal
Sequence:
MEKLLAGQTNNGSLKSKTKIVCTLGPASRSVEMVEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMENTCIPCAVMLDTKGPEIRTGFLKEGKPVELIQGQEITISTDYTMEGDSNTISMSYKKLAEDLKSGDVILCSDGTISLTVLSCDKNLGLVRARCENSAVLGERKNVNLPGIVVDLPTLTEKDQEDILQWGVPNKIDIIALSFVRKGSDLVEVRKLLGENAKSIMLMSKVENQEGVMNFDKILEYSDAFMVARGDLGMEIPIEKMFLAQKMMIQKANALGKPIVTATQMLESMTKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAHPETAVLTMSRICKEAEDFIDYDTMHKKIQDIVSLPLSPIESLAASAVSTARSLCAAAIVVLTKGGYTVELVAKYRPSVPILSVIVPEITRTDDFEWSCSESAAHVARRGLIYRGIVPVMATGASARSSNKDSTEETIQFAIEFAKKKGICKTGDSIVALHKIDGSSVVKILNVE
Protein: Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Q9UTT1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Hydrolase that deubiquitinates target proteins (By similarity). Cleaves the UBL propeptide in sde2. Involved in regulating the steady-state levels of proteins including prp4.
Subcellular location: Nucleus {ECO:0000269|PubMed:11919719, ECO:0000305|PubMed:28947618}.
Interaction partners:
- Ubiquitin carboxyl-terminal hydrolase 14
- Probable mRNA-splicing protein ubp10
- Ubiquitin carboxyl-terminal hydrolase 5
- Probable ubiquitin carboxyl-terminal hydrolase 2
- Uncharacterized membrane protein C17A5.08
- GMP synthase
- Ubiquitin thioesterase otu2
- Probable ubiquitin carboxyl-terminal hydrolase 1
- Pre-mRNA-processing protein 45
- Probable ubiquitin carboxyl-terminal hydrolase 1
Sequence:
MVLSNVDAEEVNMDSSMELEESSQEPLRADNYEEIYNSLVHHEPDLEEAAHASYSWVVKNFSTLEDKTYSPLFKAGHTTWRIVLFPKGCNQTEYASVFLEYLPQCKVEAIRKYEAELAAGKTPTIDPEIVNDETYSCCAQFALSLSNVQDPTVMQINTSHHRFRSEVKDWGFTRFVDLRKIAVPTPEFPVPFLENDEICISVTVRVLQDPTGVLWHSFVNYNSKKETGYVGLKNQGATCYMNSLLQSLFFTNIFRKTVYKIPTDNDDSRDSVAYALQRVFYNLEKQREPVSTTELTRSFGWNSFDSFMQHDIQEFNRVLQDNLEKKMKGTEVENALNDIFVGKMKSYVKCIDVNYESSRVEDFWDIQLNVKGMDTLEDSFRDAIQVETLTGDNKYYAEGHGLQDAHKGIIFESLPNVLQLQLKRFDYDMLRDMMVKINDRHEFPLEIDLEPYLSETADKSESHVYVLHGVLVHGGDLHGGHYYALIKPEKDSNWFKFDDDRVTRATIKEVLEDNYGGEPAGRAKGYNGNPFKRFMNAYMLVYFRKSRLDHILSPVTAEDVPFHVRNTLDEEHRVVERKLLEREEQQIYRRVRVLTTDGFKKYHGFDMTDFSASDDDPVLITTKIKRNANIWDLQKHLAGLLNRDTSGIRIWLMTNRQNRTVRVDLPLDKKTILVDQICDMHIRKDMDMRVYVEFLSEHNQLLADFGATDDNDFDTYIFLKIFDYETQQISGLADLHVSKNSPISSLSEWIREHLKWSSDVPITYYEEIKTGMVDVLDPNASFEKSEIQVGDIICFEKKLVHDSSSDTSHPYKSALDLYDFMAHRVVITFEPRYSDDTNNGVFDLVLTTHTNYTDMARAVANKLNVDPNYLQFTMAHLPSRTPRSVIRNPSKFTLQNAIPSTYSHNQNVVMFYEVLDITLSELERKQLIRVHFLSNGISHETQMEFYVDKEGTVEDILRQVTQKVPLNAEDASRLRLYEVYNHRILKSHLPTDGIYDLNEFSTAYVEVTPKEEQMQLKTDDAVSIVVQHFFKDLSRLHDIPFYFVLLRGETLKDLKKRLQKRLGYNDTQFSKVKLAVLQAQSFGKPYYLTDDDEVLYGELEPQSHILGLDHPPANGSAQYHGMDQAIRMK
Protein: Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (B3Gal-T8) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Beta-1,3-galactosyltransferase) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1) (Q9NS00)
Organism: Homo sapiens (Human)
Function: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9JJ05}; Single-pass type II membrane protein {ECO:0000255}.
Interaction partners:
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
- C1GALT1-specific chaperone 1
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
- Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
- Beta-1,3-galactosyltransferase 5
- C1GALT1-specific chaperone 1-like protein
Sequence:
MASKSWLNFLTFLCGSAIGFLLCSQLFSILLGEKVDTQPNVLHNDPHARHSDDNGQNHLEGQMNFNADSSQHKDENTDIAENLYQKVRILCWVMTGPQNLEKKAKHVKATWAQRCNKVLFMSSEENKDFPAVGLKTKEGRDQLYWKTIKAFQYVHEHYLEDADWFLKADDDTYVILDNLRWLLSKYDPEEPIYFGRRFKPYVKQGYMSGGAGYVLSKEALKRFVDAFKTDKCTHSSSIEDLALGRCMEIMNVEAGDSRDTIGKETFHPFVPEHHLIKGYLPRTFWYWNYNYYPPVEGPGCCSDLAVSFHYVDSTTMYELEYLVYHLRPYGYLYRYQPTLPERILKEISQANKNEDTKVKLGNP
Protein: ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Q8IDM2)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Choline/ethanolaminephosphotransferase, putative
- ethanolamine kinase
- Phosphoethanolamine N-methyltransferase
- Choline kinase
Sequence:
MSNQFLVDTIYNHGYMRKFLSILRSVKKNDKFQYIMKLCENTNIEEDEELYKVFINELHNISNTSSTRRKKNDSSCNESTNNTGNNKENGSNNTHFEDMKDINSSISNNSEEINEFEIDSSTSTQEKTKETRIYVDGIFDLSHSGHFNAMRQAKKLGDIVVVGINSDEDALNSKGVKPIYTQEERGALIAGCKWVDEVIIGTKYNVDMDLLEKYNCDYAAHGTDLAYDKNGTCCYEEVRKFNKLKIFERSYGISTTTIINHLLQAVNNSNYYSSSNNNNNNNNNNNTLVNSNNNNNNNDTNSVSTNEISDINNETNYVYNTNTNSEQLDNFNKNKDNPNILEITEEQIYNSELGISDDNKTKVSEQQHDIDTLPKNLLNRNRCHITTSQIYQFIDNNELIKKKKNKKVVYVDGSFDIFHIGHLRILENAKKLGDYLLVGMHSDEVVQKMKGKYFPVVSLLERTLNVLAMKVVDDVVIGAPWVITESFIKRFHIDVVVRGTIVDYIYSNNEIDPYDIPKKLNIYQELSSESNITTYEIIQRIEKNKKYLMRNMSKRNKKEESIWETSNTYAINN
Protein: UDP-glucose:glycoprotein glucosyltransferase (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UGT) (Q09140)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER. Unfolded, denatured glycoproteins are substantially better substrates for glucosylation by this enzyme than are the corresponding native proteins. This protein and transient glucosylation may be involved in monitoring and/or assisting the folding and assembly of newly made glycoproteins, in order to identify glycoproteins that need assistance in folding from chaperones.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:8631292}.
Interaction partners:
- Calnexin homolog
- Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Glucosidase 2 subunit alpha
- Glucosidase 2 subunit beta
- Protein OS-9 homolog
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3
- Uncharacterized protein C12G12.12
- Target of rapamycin complex 1 subunit mip1
- Putative transporter C83.11
Sequence:
MRWGFWFAIATLITICYAAKPLDVKIAATFNAPSFSALIAESLYQEKKEGFIWYLNHLSDLLDAENTTEKELYINVVNSLKREYVLSDEELSSLQFSLGLFSGAPKLQAFSSIVQSRSCDCDTWLQLDEESQVCFSDLPKDSPLFSKLYSKNPLDYEVVKTSATGIPYAVVVTSFERDLIPFHELYYKLALEGKCNYVIRYSPPSSSKLNSKLYVKGFGTHVSLKRTDYLVVDDREFPREKGDNPASFTSSRNKRSNERLFGMTSDSLQTVTPDKIAILDLLATQSIASSTDMLTAFRELTQDFPIYAHYLSIQPDVSNDLIEELNQFQSQYVPEGINTIWLNGLSLDLEETDAFSILSLIKKEKDMFDRFEALGIKSSKVLDIVTNEAFANEDSDFKFVKFHCQDDIEDWKAIHWVNEIESNPKYDNWPKSIQILLKPIYPGQLHMLGKQLHTVIYPIFPSSPSSLPLLSELIQFSRRPSPVQTGMVCAANDDDEFAQTVCKSFFYISKESGTDSALKFLYKCLNSDSSADLYSLLEEHLPLSEHDDDTLANLKKDLSSSFFDHYMSKSNSWVNRLGIDSSASEVIVNGRIISHDENYDRSMYGIFLEDIPEVQIAVAEGKISEDDNLLDFILRDASLTRNPLVYPSAKSSIKSIDIKRVLENVGSLNHEDILLIGSSNAKYSFWLVADFNEKEGLEILSLLADLLSENKDANLMLIQEGKNHVVPPLFAKLLSSPKRSSKHLQEILNSSLDPSSGVVNDMDKALKFLKKSKAVVKELGLTGECKSALLLNGRMICSFSVDSLNTADLKMLMQMEYDNYLSKLSNIAGSSRRLKNSRAISFLSSYLKTLESTPMSTSSPTKEEKLFPRDFIYNKLGVGNATFETDDFSKAYYQFVAVLDPLSKDSQKWSAILEAVSKLNGVGVRIHFNPKQTLSELPLTRFYRYSISAEPEFDALGHLEESYVEFDNLPADTLLTMDIEARDAWTVMQKDVDIDLFNIKLEHTSEAEALDSHTAIYELKNILVQGYSQEEFRKSPPRGMQLKLGNLTNSHVTDTIVLSNLGYFQLKANPGVWTLEPMDGRSSQFYEILSLNKKNSYKDPQVIVDSFEGVTLNPVMRRKPGFESADIMDEDLSSHKFFDKIKKSLSFFNFKRKEASINIFSVASGHLYERFLYIMTKSVIEHTDKKVKFWFIENFLSPSFKSSIPAIAKKYNFEYEYITYNWPHWLRKQEEKQREIWGYKILFLDVLFPLELHKVIYVDADQIVRADLQELMDMDLHGAPYGYTPMCDSREEMEGFRFWKKGYWKKFLRGLKYHISALYVVDLDRFRKMGAGDLLRRQYQLLSADPNSLSNLDQDLPNHLQHLIPIYSLPQDWLWCETWCSDESLKTAKTIDLCQNPLTKEKKLDRARRQVSEWTSYDNEIASVLQTASSQSDKEFEEKDNNSSPDEL
Protein: Protein SEY1 (EC 3.6.5.-) (Synthetic enhancer of YOP1 protein) (Q99287)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cooperates with the reticulon proteins RTN1 and RTN2 and the tubule-shaping DP1 family protein YOP1 to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03109, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:19665976}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03109, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:19665976}. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Interaction partners:
- Putative guanine nucleotide-exchange factor SED4
- Protein YOP1
- Reticulon-like protein 1
- Endoplasmic reticulum junction formation protein lunapark
- Syntaxin UFE1
- Reticulon-like protein 2
- Pore membrane protein of 33 kDa
- Acyl-coenzyme A diphosphatase SCS3
- Protein transport protein USE1
- Protein transport protein SEC20
Sequence:
MADRPAIQLIDEEKEFHQSALQYFQQCIGNRDVGLDYHVISVFGSQSSGKSTLLNVLFNTNFDTMDAQVKRQQTTKGIWLAHTKQVNTTIEIDNDRPDIFVLDVEGSDGSERGEDQDFERKAALFAIAVSEVLIVNMWEQQIGLYQGNNMALLKTVFEVNLSLFGKNDNDHKVLLLFVIRDHVGVTPLSSLSDSVTRELEKIWTELSKPAGCEGSSLYDYFDLKFVGLAHKLLQEDKFTQDVKKLGDSFVMKGTENYYFKPQYHHRLPLDGWTMYAENCWDQIERNKDLDLPTQQILVARFKTEEISNEALEEFISKYDESIAPLKGNLGSLTSQLVKLKEECLTKYDEQASRYARNVYMEKREALNTKLNSHISGTINEFLESLMEKLWDDLKLEVSSRDKATTSFVESVAAGKSKIEKEFNESMETFKKLGLLISNEEITCKFSDDIEERIKQLRDAELKAKIGRIKKNLVPELKDHVIHLLSHPSKKVWDDIMNDFESTIKDNISAYQVEKDKYDFKIGLSESENAKIYKNIRILAWRTLDTTVHDYLKIDTIVSILRDRFEDVFRYDAEGSPRLWKTEEEIDGAFRVAKEHALEVFEVLSLAVTSDNVEIIPDVPMAEEESGEDNEIYRDNEGVFHSRRFAHILTELQKENVLDQFRRQINITVLDSKRSIITTRTHIPPWIYVLLAVLGWNEFVAVIRNPLFVTLTLILGATFFVIHKFGLWGPVVNVVQSAVGETRTAIKDKLRQFVVEDHEVKESFEMKDFSKNEQKEK
Protein: Uncharacterized protein (Q383J2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MASCVTPHTRVFLFICFFFLLFPCLSLTCRSGPGGWDENEGMRYPGRRTFCRVASTATCGVLLANTLLISYACYGKDTFFLQHWNYGKPVIMKKTHLLAFWENALSAGERGCVQAWLDAMSLKSPSHSLFSPLFVLQDTLLFVCGLPEWRSAVLTLSKLLGTDVVPYCMEIRRERQGDVIFLHLKLETELRPRFLQWAKGEKGGTLSFPSVATLQLEENSPGSVGSNKWRIAAAEHRWFGGPIVSQQSATLRSPWGDVGDILRRFFAYSMLGISRILVREKEL
Protein: Gamma carbonic anhydrase like 1 (F4KAQ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00034694}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00034694}; Matrix side {ECO:0000256|ARBA:ARBA00034694}.
Interaction partners:
Sequence:
MATSIARLSRRGVTSNLIRRCFAAEAALARKTELPKPQFTVSPSTDRVKWDYRGQRQIIPLGQWLPKVAVDAYVAPNVVLAGQVTVWDGSSVWNGAVLRGDLNKITVGFCSNVQERCVVHAAWSSPTVGCNGDKAVSHGCELVFAPRFRQGKFSRLPAATIIDRYVTVGAYSLLRSCTIEPECIIGQHSILMEGSLVETRSILEAGSVVPPGRRIPSGELWGGNPARFIRTLTNEETLEIPKLAVAINHLSGDYFSEFLPYSTVYLEVEKFKKSLGIAV
Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (B1WC09)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Interaction partners:
Sequence:
MILIPRMPLVLLLLLLILGSAKAQVNPAICRYPLGMSGGHIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGNRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRVRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSETSEWEPTAVYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMAPTTFDPMLKVDDSNTRILIGCLVAIIFILLAVIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSESSMFNNNHSSSPSEQESNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPAQPNGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDANIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEPLSSGSSNATVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPAVCPDSVYKLMLSCWRRETKHRPSFQEIHLLLLQQGAE
Protein: CBL-interacting serine/threonine-protein kinase 8 (EC 2.7.11.1) (SNF1-related kinase 3.13) (SOS2-like protein kinase PKS11) (Q9STV4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity).
Interaction partners:
- Calcineurin B-like protein 1
- Calcineurin B-like protein 9
- Protein NRT1/ PTR FAMILY 6.3
- Calcineurin B-like protein 4
- Calcineurin B-like protein 7
- Calcineurin B-like protein 3
- Calcineurin B-like protein 10
- Protein NLP7
- Protein phosphatase 2C 77
- LOB domain-containing protein 37
Sequence:
MVVRKVGKYELGRTIGEGTFAKVKFAQNTETGESVAMKIVDRSTIIKRKMVDQIKREISIMKLVRHPCVVRLYEVLASRTKIYIILEYITGGELFDKIVRNGRLSESEARKYFHQLIDGVDYCHSKGVYHRDLKPENLLLDSQGNLKISDFGLSALPEQGVTILKTTCGTPNYVAPEVLSHKGYNGAVADIWSCGVILYVLMAGYLPFDEMDLPTLYSKIDKAEFSCPSYFALGAKSLINRILDPNPETRITIAEIRKDEWFLKDYTPVQLIDYEHVNLDDVYAAFDDPEEQTYAQDGTRDTGPLTLNAFDLIILSQGLNLATLFDRGKDSMKHQTRFISHKPANVVLSSMEVVSQSMGFKTHIRNYKMRVEGLSANKTSHFSVILEVFKVAPSILMVDIQNAAGDAEEYLKFYKTFCSKLDDIIWKPPDASMRNRVTKAKSKRR
Protein: Transcriptional regulatory protein (O53830)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Mycothiol acetyltransferase
- Sensor-like histidine kinase SenX3
- Sensor histidine kinase PdtaS
- Sensor histidine kinase component HK1
- Sensor histidine kinase TrcS
- histidine kinase
- Probable sensor histidine kinase TcrY
- Transcriptional regulatory protein PdtaR
- Phosphate import ATP-binding protein PstB 1
Sequence:
MLELLLLTSELYPDPVLPALSLLPHTVRTAPAEASSLLEAGNADAVLVDARNDLSSGRGLCRLLSSTGRSIPVLAVVSEGGLVAVSADWGLDEILLLSTGPAEIDARLRLVVGRRGDLADQESLGKVSLGELVIDEGTYTARLRGRPLDLTYKEFELLKYLAQHAGRVFTRAQLLHEVWGYDFFGGTRTVDVHVRRLRAKLGPEHEALIGTVRNVGYKAVRPARGRPPAADPDDEDADPGRDGMQEPLVDPLRSQ
Protein: Probable phospholipid-transporting ATPase 5 (AtALA5) (EC 7.6.2.1) (Aminophospholipid flippase 5) (Q9SGG3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in transport of phospholipids.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Adenine phosphoribosyltransferase 4
- Adenine phosphoribosyltransferase 3
- Ras-related protein RABA1g
Sequence:
MARGRIRSKLRLSLLYTFGCLRPATLEGQDSQPIQGPGFSRTVFCNQPHMHKKKPLRYRSNYVSTTRYNLITFFPKSLYEQFHRAANLYFLVAAILSVFPLSPFNKWSMIAPLVFVVGLSMLKEALEDWRRFMQDVKINARKTCVHKSDGVFRQRKWKKVSVGDIVKVEKDEFFPADLLLLSSSYEDGICYVETMNLDGETNLKVKRSLEVSLPLDDDESFKNFMATIRCEDPNPNLYTFVGNLEFERQTFPLDPSQILLRDSKLRNTTYVYGVVVFTGFDTKVMQNSTKSPSKRSRIERTMDYIIYTLLVLLILISCISSSGFAWETEFHMPKMWYLRPGEPIDFTNPINPIYAGVVHLITALLLYGYLIPISLYVSIEVVKVWQASFINQDLHMYDDESGVPANARTSNLNEELGQVHTILSDKTGTLTCNQMDFLKCSIAGTSYGVRSSEVEVAAAKQMAVDLEEHGEISSTPQSQTKVYGTWDSSRTQEIEVEGDNNYNTPRAPIKGFGFEDNRLMNGNWLRESQPNDILQFFRILAICHTAIPELNEETGKYTYEAESPDEASFLAAAREFGFEFFKRTQSSVFIRERFSGSGQIIEREYKVLNLLEFTSKRKRMTVIVRDEEGQILLLCKGADSIIFERLAKNGKTYLGPTTRHLTEYGEAGLRTLALAYRKLDEDEYAAWNSEFLKAKTSIGSDRDELLETGADMIEKELILIGATAVEDKLQKGVPQCIDKLAQAGLKLWVLTGDKMETAINIGFACSLLRQGMRQICITSMNSEGGSQDSKRVVKENILNQLTKAVQMVKLEKDPHAAFALIIDGKTLTYALEDDMKYQFLALAVDCASVICCRVSPKQKALVVRLVKEGTGKTTLAIGDGANDVGMIQEADIGVGISGVEGMQAVMASDFSIAQFRFLERLLVVHGHWCYKRIAQMICYFFYKNIAFGLTLFYFEAFTGFSGQSVYNDYYLLLFNVVLTSLPVIALGVFEQDVSSEICLQFPALYQQGTKNLFFDWSRILGWMCNGVYASLVIFFLNIGIIYSQAFRDNGQTADMDAVGTTMFTCIIWAANVQIALTMSHFTWIQHVLIWGSIGMWYLFVAIYSMMPPSYSGNIYRILDEILAPAPIYWMATLLVTVAAVLPYVAHIAFQRFLNPLDHHIIQEIKYYGRDIEDARLWTRERTKAREKTKIGFTARVDAKIRHLRSKLNKKQSNLSHFSAQDAMSPRSL