wanglab/gogpt-training-data huggingface dataset:
Protein: Spore development regulator vosA (Viability of spores protein A) (Q5BBX1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes. Controls primarily the late process of sporulation including trehalose biogenesis. The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes. The vosA-velB complex binds to the beta-glucan synthase fksA gene promoter in asexual spores for repression.
Subcellular location: Nucleus {ECO:0000269|PubMed:17912349, ECO:0000269|PubMed:21152013}. Note=Localizes in the nucleus of mature conidia (PubMed:17912349). {ECO:0000269|PubMed:17912349}.
Interaction partners:
- Velvet complex subunit B
- Protein-methionine methyltransferase laeA
- Conidiophore development regulator abaA
- C2H2 type master regulator of conidiophore development brlA
- Developmental regulatory protein wetA
- Alpha,alpha-trehalose-phosphate synthase
- Sexual development regulator velC
Sequence:
MSAANYPDPSLPRPSTSDDFELIVRQNPNRARVAGGKEKERKPVDPPPIVQIRVREEGTYLAQHYLQSPYFFMSCSLYDAQEDAPASIPPSTALTGTLVSSLHRLKDVDNTDGGFFVWGDLSIKVEGDFRLKFSLFEMRKTDVVFLKSIVSERFTVSPPKSFPGMAESTFLSRSFADQGVKLRIRKEPRTLIKRTAPRPEEYPQAAIPRSPSDRTAMQIPGSSYPAPPYQPTSRDYSYYAPVKRQRTSVDYGARGMYDADGRMRQMETYPQTATLYGQPGGYPTPMMGYPSGHGGVPDYAMSYGLPPSAQVPQMQDPAAQSRSSQQATMQSLGMVNPPGTPTPDSARAMMQQAYPRPQYSASTAVLPPLQQSRNYPQGTNGATRGYYEQSPQATPILPSQPLGTSEAERYGVPPGHTGYDHTGSANGTPR
Protein: S-formylglutathione hydrolase (AtSFGH) (EC 3.1.2.12) (Esterase D) (Q8LAS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine hydrolase which catalyzes the hydrolysis of S-formylglutathione to glutathione and formic acid (Probable). Also hydrolyzes S-acetylglutathione and a range of carboxyesters in vitro. Involved in the detoxification of formaldehyde.
Interaction partners:
- Alcohol dehydrogenase class-3
- Alcohol dehydrogenase-like 3
- Alcohol dehydrogenase-like 4
- Probable carboxylesterase 5
- Alcohol dehydrogenase-like 7
- Alcohol dehydrogenase class-P
- Alcohol dehydrogenase-like 1
- Alcohol dehydrogenase-like 6
- Alcohol dehydrogenase-like 2
- Alcohol dehydrogenase-like 5
Sequence:
MASGLSEIGSTKMFDGYNKRYKHFSETLGCSMTFSIYFPPSASSSHKSPVLYWLSGLTCTDENFIIKSGAQRAASTHGIALVAPDTSPRGLNVEGEADSYDFGVGAGFYLNATQEKWKNWRMYDYVVKELPKLLSENFSQLDTTKASISGHSMGGHGALTIYLRNLDKYKSVSAFAPITNPINCAWGQKAFTNYLGDNKAAWEEYDATCLISKYNNLSATILIDQGENDQFYPDQLLPSKFEEACKKVNAPLLLRLHPGYDHSYYFIATFIEDHISHHAQALEL
Protein: Nucleosome assembly protein 1-like 2 (Brain-specific protein, X-linked) (P51860)
Organism: Mus musculus (Mouse)
Function: Acidic protein which may be involved in interactions with other proteins or DNA.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MAESVDHKELSESNQEELGSQVMAEGPGESQDRSEGVSIEPGDGGQHGEETVAAGVGEEGKGEEAAAGSGEDAGKCGGTDEDSDSDRPKGLIGYLLDTDFVESLPVKVKCRVLALKKLQTRAAHLESKFLREFHDIERKFAEMYQPLLEKRRQIINAVYEPTEEECEYKSDCEDYFEEEMDEEEETNGNEDGMVHEYVDEDDGYEDCYYDYDDEEEEEEEDDSAGATGGEEVNEEDPKGIPDFWLTVLKNVEALTPMIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLACYDPHPYRGTAIEYATGCDIDWNEGKNVTLRTIKKKQRHRVWGTVRTVTEDFPKDSFFNFFSPHGISLNGGDENDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDEIYDKIIYDDWMAAIEEVKACCKNLEALVEDIDR
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 (A0A8I5ZQQ2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAADEVAGGARKATKSKLFEFLVHGVRPGMPSGARMPHQGAPMGPPGSPYMGSPAVRPGLAPAGMEPARKRAAPPPGQSQAQGQGQPVPTAPARSRSAKRRKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRVDIQEALKRPMKQKRKLRLYISNTFNPAKPDAEDSDGSIASWELRVEGKLLDDPSKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTPTTQETDGFQVKRPGDLSVRCTLLLMLDYQPPQFKLDPRLARLLGLHTQSRSAIVQALWQYVKTNRLQDSHDKEYINGDKYFQQIFDCPRLKFSEIPQRLTGLLLPPDPIVINHVISVDPSDQKKTACYDIDVEVEEPLKGQMSSFLLSTANQQEISALDSKIHETIESINQLKIQRDFMLSFSRDPKGYVQDLLRSQSRDLKVMTDVAGNPEEERRAEFYHQPWSQEAVSRYFYCKIQQRRQELEQSLVVRNT
Protein: Ammonium transporter (Q8TFN9)
Organism: Emericella nidulans (Aspergillus nidulans)
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU362002}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362002}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MASEGMAPFTPEYASYNWTGAPSDYSSLATNELGGNSRVENLNKWYQSGDQAYIIVASAMVMLMVPGLGFLYSGLARRKSALSMIWACMGSMCVVTFQWYFWGYSLAFSPTATNGYIGNLRNFGLMKVLADPSPGSPLVPNLLYAFYQMQFCAVTAAIIMGAVAERGRLLPAMVFTFVWATIVYCPIACWVWNVNGWAFNYGVLDYAGGGPVEICSGLSALAYSMVLGRRQERMMLNFRPHNVSLILLGTVFLWFGWLGFNGGSSFGANMRATMACWNTNLTAAFGAITWVILDWRLARKWSMVGWCSGTISGLVAATPASGFLPPWASVVLGIVTGIVCNYSTKVKYWIRIDDSMDVFAEHGVAGIVGLIFNAFFADDAIVGLDGVNTGSEMGGWLIHNWKQLYIQIAFIVAASAYSFVVSAIVAYAINAIPGLKLRASEEAELLGMDDDQLGEFAYDYVEVRRDYLAWTPQKHDQHADGHEVPAAARYGIGEHSEMMLDGEAPTGATNSRGSEVSGVQEINVKEESQRPAPPTDAEKAAQGL
Protein: BRO1 domain-containing protein (Q386T1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endosome {ECO:0000256|ARBA:ARBA00004177}.
Interaction partners:
- Uncharacterized protein
Sequence:
MTTFEHLPDLLPLLPFRRGKKDSVDWTLCIRYISSNFTSNYTSNVESALRQMNSFHHTIVQTCHEDATQAPTESFIEEKLTPYCKLVAMVQSHLPLHGGLVHGDLRFIWYDSFDGTKYESKNANLELLSCVYNLAASWAYIGAQQTRDGLVDKLKVASKAFQNATGYYEMAEGLLSRLPPELATGDLTHESLSLLKRICAAMTHHCAYLKAEIDMKDNHSVLSKIAREGGKVYQIVATSLKESAWYTNSRRGSKAVLLEQELRTLCCVFNARAHLHVAEVHSNANDQGIAVAHFNEAQKHLQQIEKLHSVELRSWISSIISNVNKGNERALSMNNTVYFCRVPNEVEPPAGLPRPLGKATEHQSFFAFESTRENDPLFGIVPAHIASTAAGWRDRQRSLVSACSTSSRSTRKRAAELLQRLGVTAVIEVLSGETKDRGRVPAQLRSKIESLRRNKAGEAVNIVQTLVNMVKICDKIYVSVQEVVKKVKNELEEERRRDAQYMETYGNSMWRGMCCSASEVQQYHSIQVAIGKYEEDLQRELVEPFGQAKIVLDENLKCLGRLDWPMEDLDALMPFTKTEDVRQQSEKVLQQIERLKKLTACIHELEASQNNRLQELEHALETDDVARALSAVEESQYQVVMAKESKKISDMIDGVSSSVRKEEEVLREIEEVVESLAVLRSSDPILEEAEKVCNTLECGCSAYAELHRDFSNIVKKGSAILKGLEVVLSSAKSFVATRKSEAEQIRVSLDEQIAHKIAELEHKKESERAVEESQRRQEELQLQVQLLERQLDPQRSERMAEVLRRQREAAAAFSSTSASLPPSNMSGVDAPPAYDFVVNNVHPNVPTHTHPPQYYAPHNPLS
Protein: Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4) (P0C588)
Organism: Rattus norvegicus (Rat)
Function: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions. May play a role in biomineralization and retinal function.
Subcellular location: Cell membrane {ECO:0000305|PubMed:15840172}; Multi-pass membrane protein {ECO:0000305|PubMed:15840172}.
Interaction partners:
- non-specific serine/threonine protein kinase
- Solute carrier family 41 member
Sequence:
MAPGGGGGRRDGWPARGRLLLAALLLLLWTRAASGQSSPQQSVILGMRLASCNKSCGMNPDGIIFVSEGSTVNLRLYGHRLGEISSNLISFTEVDDAETVHNSTNCLELTKDLVVQRLVNVSRGNTSGMLVVITKFLRRSENMKLYALCTRTRADGPWLKWTDKDSLLFMVEEHGRFLPLWLHILLVLVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGIMAVASSTIGIVIFGEILPQALCSRHGLAVGANTIVLTKIFMLLTFPLSFPISKLLDFVLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLHDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDTYTDNRTRKRVSMKNKRDFSAFKDADNELKVKISPQLLLAAHRFLATEVPQFSPSLMSEKILLRLLKYPDVIQELRFDEHNKHCTRHYLYTRNKPADCFILILQGKVEVEAGKENMKFETGAFSYYGTMALSLAPPDRSPAHPTPLSRSASLSYPDRNTDMTPSSLAGSNQFGSCILGQYVSDFSVRALTDLQYIKVTRQQYQNGLLASRMDNSPQLTLDGCATCTENLSERPELPVVDETTTLLNERNLLLHRASQEGTI
Protein: Siroheme decarboxylase NirL subunit (EC 4.1.1.111) (P95413)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Involved in heme d1 biosynthesis. Catalyzes the decarboxylation of siroheme into didecarboxysiroheme (By similarity).
Interaction partners:
- Siroheme decarboxylase NirG subunit
- Pre-heme d1 synthase
- Dihydro-heme d1 dehydrogenase
- Protein NirF
- Siroheme decarboxylase NirD subunit
- Cytochrome c55X
- Nitrite reductase
- Siroheme decarboxylase NirH subunit
- uroporphyrinogen-III C-methyltransferase
- Cytochrome c-551
Sequence:
MNPVEPLAAPQRQHLRYLLEQGLPLASRPYRVLAERIGAGEDEVLEQVRRWDEDGLFRRFGVILHHRALGYTANAMLVLDVADAEVDAVGRALAHETIVSLCYRRPRRLPMWPYNLFCMIHGRERGEVERQIEALLERHALRQTPHRWLFSLRAYKQCGGRYTAPPADLERRHG
Protein: Jupiter microtubule associated homolog 2 (cDNA FLJ50401, highly similar to Hematological and neurological expressed1-like protein) (cDNA, FLJ79413, highly similar to Hematological and neurological expressed 1-like protein) (A6NGP5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMRAMKPPGGESSNLFGSPEEATPSSRPNRMASNIFGPTEEPQNIPKRTNPPGGKGSGIFDESTPVQTRQHLNPPGGKTSDIFGSPVTATSRLAHPNKPKDHVFLCEGEEPKSDLKAARSIPAGAEPGEKGSARKAGPAKEQEPMPTVDSHEPRLGPRPRSHNKVLNPPGGKSSISFY
Protein: TPD1 protein homolog 1A (Protein MICROSPORELESS 2) (TPD1-like protein 1A) (OsTDL1A) (Q2QR54)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in cell specification during anther development. Required for the differentiation of primary parietal cells into secondary parietal cells in anthers. May serve as an extracellular ligand for the MSP1 receptor kinase to limit sporocyte number in ovules.
Interaction partners:
- Leucine-rich repeat receptor protein kinase MSP1
Sequence:
MRVSSASSTPPPPAFAAAAWAVVLLAMLRSDVALAAAASSNDDTGLSPLMPPPPLAAPVPAAVSPAPATPPAVLSPRKLLRPQGADVVGVGFVSGSGGGGGGDGVRTRRVDDGCAGADDIAIYQGRATPLPSGVPAYTVDVMNRCAGGGGGDEECAIAGIHVRCGWFSSVSLVDPRVFRRLGHDDCLLNDGRPLLAGETVSFEYTNSFPYKLSVSVATCVVDPAAP
Protein: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1) (Q9UKM7)
Organism: Homo sapiens (Human)
Function: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10409699}; Single-pass type II membrane protein {ECO:0000269|PubMed:10409699}.
Interaction partners:
- Alpha-mannosidase 2C1
- Neutral alpha-glucosidase AB
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
- Glycoprotein endo-alpha-1,2-mannosidase
- Alpha-mannosidase 2
- Protein OS-9
- Endoplasmic reticulum lectin 1
- Mannosyl-oligosaccharide glucosidase
Sequence:
MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENYDNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA
Protein: Homeobox protein pnx (Posterior neuron-specific homeobox) (F1R2J1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional repressor. Activity as a repressor is enhanced by binding to the corepressor tle3a.
Subcellular location: Nucleus {ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682, ECO:0000269|PubMed:12642490}.
Interaction partners:
- Transducin-like enhancer protein 3-A
Sequence:
MHEETSNSTLQGKTSFSIADILDPAKFNGTRETREISNNRESPKTTSPTQDPSAPNIANASAAKVKSKRIRTAFTLDQLRILERSFQSSHYLSVFERHCIASALGLSETQVKIWFQNRRTKWKKELDGHGGEEQSHCAPTALTQNPIMYALPGHHANHHVHYYPQQTHYLNTSFHPQTLMMY
Protein: Carnosine N-methyltransferase 2 (EC 2.1.1.22) (Histamine N-methyltransferase-like) (HNMT-like) (U3NEE3)
Organism: Gallus gallus (Chicken)
Function: N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles.
Interaction partners:
- Carnosine synthase 1
- Carnosine dipeptidase 1
- M20_dimer domain-containing protein.
- Carnosine N-methyltransferase
- SUN domain-containing protein.
- Uncharacterized protein.
- ArfGAP with coiled-coil, ankyrin repeat and PH domains 3.
- Leucine zipper protein 2
- Uncharacterized protein.
- ArfGAP with coiled-coil, ankyrin repeat and PH domains 1.
Sequence:
MEPTPEMKRNRLPSMNFEAEILADPHDNSELYVIPSMRSLTAEEYVEAFQSFLDHSTEHQCMDEFNKEVMPHIMAGLGNGKSTINILGVGSGTGEQDLKMIQILQAAHPGVLINNEIIEPNPQHVAAYKELVNRAPDLQGVSFTWHQLTSSEYEQQVKEKNTHKKFDFIHMIQMLYRVEDIPNTIKFFHSCLNHQGKLLIIILSDSSGWASLWKKYRHCLPSTDSGHYITSDSITAVLRKLGIKYHVYEFPSGWDITECFIEGDPAGGHMMDFLTGTKNFLGTAPAALRSRLQEALCQPECSSRKDGRVIFCNNLSMIVAES
Protein: Rab3 interacting molecule, isoform T (A0A0B4K6L8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Synapse {ECO:0000256|ARBA:ARBA00034103}.
Interaction partners:
Sequence:
MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRRKQDEVVTLEMQIRQRSEQQKKAGVELDATCHICLKTKFADGVGHICHYCNIRCCARCGGKVTLRSNKVIWVCILCRKKQELLSKTGQWINKTAAQQDGFIRRIEPDGSSDISQHPIVDPHDTTDKRPKLERTRSAAEKENLPMQRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGNFGGVQGVQTVLSPGDLQIHANNPVNWQTSADNTRLIGHMILRKYYDGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYGANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLSDTANDRKKGGGVDQERSPKGGSGMGKKSNSTSQLSATGRKRRMGFGKKGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQFFGDGAGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSL
Protein: Nexilin (F-actin-binding protein) (Nelin) (Q0ZGT2)
Organism: Homo sapiens (Human)
Function: Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Z2J4}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Z2J4}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9Z2J4}. Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ. {ECO:0000250|UniProtKB:Q9Z2J4}.
Interaction partners:
- Neurabin-1
- Src substrate cortactin
- Hematopoietic lineage cell-specific protein
- Vinculin
- RNA-binding protein 20
- Neurabin-2
- Actin, alpha cardiac muscle 1
- Anillin
- Cysteine and glycine-rich protein 3
- Mitoguardin 1
Sequence:
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIESKN
Protein: SLIT and NTRK-like protein 2 (Q9H156)
Organism: Homo sapiens (Human)
Function: It is involved in synaptogenesis and promotes excitatory synapse differentiation. Suppresses neurite outgrowth (By similarity).
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:27812321, ECO:0000269|PubMed:35840571}. Cell projection, dendrite {ECO:0000269|PubMed:35840571}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase delta
- Neuronal pentraxin-1
- Receptor-type tyrosine-protein phosphatase S
- Interleukin-1 receptor accessory protein-like 1
Sequence:
MLSGVWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEPATPAYTISATELLEKQATPREPELLYQNIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKPNHPLLQAKPQSEPDYLEVLEKQTAISQL
Protein: Zinc transporter 7 (Solute carrier family 30 member 7) (Znt-like transporter 2) (Q9JKN1)
Organism: Mus musculus (Mouse)
Function: Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:12446736, ECO:0000269|PubMed:19283665}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000269|PubMed:12446736}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19283665}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q5BJM8}. Mitochondrion {ECO:0000250|UniProtKB:Q5BJM8}.
Interaction partners:
- Zinc transporter ZIP9
- Zinc transporter SLC39A7
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter ZIP11
- Zinc transporter ZIP13
- Zinc transporter ZIP1
- Metal cation symporter ZIP14
- Zinc transporter ZIP5
- Metal cation symporter ZIP8
- Zinc transporter ZIP6
Sequence:
MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLVGIFVFNHGGHGHSHGSGHGHSHSLFNGALDHSHGHEDHCHSHEAKHGAAHSHDHDHAHGHGHLHSHDGPSFKATAGPSRQILQGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPSLENTLPQCYQRVQQLQGVYNLQEQHFWTLCSDVYVGTLKLVVAPDADARWILSQTHNIFTQAGVRQLYVQIDFAAM
Protein: NAD-dependent protein deacylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog) (B4EVF5)
Organism: Proteus mirabilis (strain HI4320)
Function: NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins. Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation. Modulates the activities of several proteins which are inactive in their acylated form. Catalyzes deacetylation and de-2-hydroxyisobutyrylation of Eno at 'Lys-326' and 'Lys-343', respectively, thereby promoting the enolase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01121}.
Interaction partners:
Sequence:
MMKLKLRHRRLRKFRKIKSLRRQHSRCRYFHLTHKTEHEMNLPKVVVLTGAGISAESGIKTFRSEDGLWEEHRVEDVATPEGYHRNPKLVQQFYNERRRQLQQPSIQPNEAHYALAKLEQYLGKDNFLLVTQNIDNLHEKAGSKHILHMHGELLKVRCPQSGQVFEWKGDLSTTDYCHCCQFPSPLRPHIVWFGEMPIGMDEIYHALAQADLFIAIGTSGNVYPAAGFVHEARLTGAHTVELNLEPSLVESEFEEKHYGPASQVVDAYVHKLFDLINDPKADLTQ
Protein: Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A) (P43081)
Organism: Mus musculus (Mouse)
Function: Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light.
Subcellular location: Membrane; Lipid-anchor {ECO:0000250|UniProtKB:P46065}. Photoreceptor inner segment {ECO:0000269|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:15961391, ECO:0000269|PubMed:9620085}. Note=Subcellular location is not affected by light or dark conditions.
Interaction partners:
- Retinal guanylyl cyclase 1
- Retinal guanylyl cyclase 2
- Guanylate cyclase D
- Guanylyl cyclase-activating protein 2
- Translation factor Guf1, mitochondrial
- Cyclic nucleotide-gated channel alpha-1
- Guanine nucleotide-binding protein G
- Cyclic nucleotide-gated channel beta-1
- Protein RD3
- Rhodopsin kinase GRK1
Sequence:
MGNIMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIRAIRTINPWSDSSMSAEEFTDTVFAKIDINGDGELSLEEFMEGVQKDQMLLDTLTRSLDLTGIVRRLQNGEHEEAGTGDLAAEAAG
Protein: At5g58630 (Q8GWQ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MKMKSSPSPASSLSLGSKTRSFGCISIILQRFLCSGTSSTYPSDLITEPSFKSRDFIPEPLRGRGDGPGAVARLMGLDSIPVIDKTRFLSRSHSVNHLKRDDDEIQGKHRRVKSTLEYVELEDDDFFILSFEKDKNDKELGTRNCKKRRDTRGNQSKTEDQTHLEGKENNINAMNVSPGRERLEIGELMQRRKEKRKSRRKRKETKLRQNIEKENWVQSNGCWSKEEDLVNCEVRSTKEEEECGSCDDSSPVSVLDYDRYAGVRVTPSPGNISRRRLSSELESSKLNETIEQDHITLTSRSKDQEIRLHGYQEMWLMICKLTVSDLEGSDWFNGKALKLEDIEGIISEDIVSNILDQLLEETITTLSLTSQV
Protein: Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (W5U6M1)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}.
Interaction partners:
Sequence:
MEGKRALALLCVLWSVFCVTECVRRDGTRRRRRETCADDGLYSSSSGLQCCRCPIGHHLVRDCTSNGTAPECDACERGSYLDHANALSKCEPCKTCGVNDNMIEEKRCTPASNAMCRCMDGYYCDKGAECKVCYPCSTCEFGIKVPCNLTSDAQCHEQGPNTTTASIKIPILIIAFIIIIIIAAVVYLWKKKLFCFKPPEPLKTPEPLDLLIDKDLGEFLPKISEILGVRVILQVVRQQRLLSEGVIDNITVENPHDASERAYHLLKAWYEKHGKTGAYRTLRENLIAIGKRSKADEVRELIGERENNNVT