wanglab/gogpt-training-data huggingface dataset:
Protein: THO complex subunit 5 (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) (Q13769)
Organism: Homo sapiens (Human)
Function: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.
Subcellular location: Nucleus {ECO:0000269|PubMed:19059247, ECO:0000269|PubMed:19165146}. Cytoplasm {ECO:0000269|PubMed:19059247}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000269|PubMed:19059247}.
Interaction partners:
- THO complex subunit 3
- THO complex subunit 2
- THO complex subunit 7
- THO complex subunit 1
- Spliceosome RNA helicase DDX39B
- THO complex subunit 6
- THO complex subunit 4
- Chromatin target of PRMT1 protein
- Nuclear RNA export factor 1
- SAP domain-containing ribonucleoprotein
Sequence:
MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR
Protein: Interferon regulatory factor 7 (F1QNG2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Myeloid differentiation primary response protein MyD88
- Interferon regulatory factor 3
- Serine/threonine-protein kinase TBK1
- Mitochondrial antiviral-signaling protein
- Interferon-induced with helicase C domain 1.
- TNF receptor-associated factor
- Interferon
- TNF receptor-associated factor 6
- S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
- Toll-like receptor 3
Sequence:
MQSTNAKPQFGPWLIEQVESGQYEGLSMIGHDIFRIPWKHNARRDLGDADVKIFKEWAIVSGKINEYPNDKAKWKTNFRCALHSLKSFEMLEDHSKDPDDQHKIYRIIRPQNHQEIKSAIQSAEAVQRQLPFIAEVYNASNHMSQDMELELLNLVETMDLNLHAVSQSLKTYSQPNIQTTSSNYFETTYSDDPCMQNNIPASVQQSHTTVDQWNLDLEISISYRRTEVLKTRLCSSLIHFFYQCDPSELRGEQIRFPTTDCLIDVKQIQYTKRILDSIQRGLQLEVNQYGIYGFRQDKCKVFVSTSDPCEIQKPEPRKLQQNSKEQLLSFDKYIRDLLDFKENRGGSPDYTIYLCFGEKLHDGKPLEKKLITVKVVPLICRELHERAQMEGASSLRNDNVSLQISHNSLYDLINSLGLPSVE
Protein: Flavin-containing monooxygenase FMO GS-OX3 (EC 1.14.13.237) (Flavin-monooxygenase glucosinolate S-oxygenase 3) (Q9SXE1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the conversion of methylthioalkyl glucosinolates of any chain length into methylsulfinylalkyl glucosinolates. Prefers probably short-chain methylthioalkyl glucosinolates in cv. Landsberg erecta.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Interaction partners:
- Methylthioalkylmalate synthase 1, chloroplastic
- 3-isopropylmalate dehydratase small subunit 3
- Probable inactive 2-oxoglutarate-dependent dioxygenase AOP2
- Cytosolic sulfotransferase 17
- Methionine aminotransferase BCAT4
- Transcription factor MYB29
- Methylthioalkylmalate synthase 3, chloroplastic
- 3-isopropylmalate dehydratase small subunit 2
- S-alkyl-thiohydroximate lyase SUR1
- Dihomomethionine N-hydroxylase
Sequence:
MAPAQNQITSKHVAVIGAGPAGLITSRELRREGHSVVVFEREKQVGGLWVYTPKSDSDPLSLDPTRSKVHSSIYESLRTNVPRESMGVRDFPFLPRFDDESRDARRYPNHREVLAYIQDFAREFKIEEMIRFETEVVRVEPVDNGNWRVQSKNSGGFLEDEIYDAVVVCNGHYTEPNIAHIPGIKSWPGKQIHSHNYRVPDPFENEVVVVIGNFASGADISRDIAKVAKEVHIASRAREPHTYEKISVPQNNLWMHSEIDTTHEDGSIVFKNGKVIFADSIVYCTGYKYNFPFLETNGYLRIDEKRVEPLYKHVFPPALAPGLAFVGLPAMGIVFVMFEIQSKWVAAVLSGRVTLPSTDKMMEDINAWYASLDALGIPKRHTHTIGRIQSEYLNWVAKESGCELVERWRGQEVDGGYLRLVAHPETYRDEWDDDELIEEAYNDFSRKKLISVDPSYYLENGR
Protein: Macrophage-expressed gene 1 protein (Perforin-2) (A9C3Q1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle, phagosome membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004265}.
Interaction partners:
- Cis-aconitate decarboxylase
- Si:ch211-232m10.4
Sequence:
MNLLYIFLTFFVLFCKSDGFIRPSNGLRECRQNSNLTALEVLPGGGWDNLRNLDVGRVMNLTYSQCQTTEDGLYLIPDEVFVIPRKTSGVETHSETIMSWLDQRSSTSGSINADASYLTVLNGKFSEENTRMKIHQVRGNSVTTRVQVRNHLYTVNAYPDFTLDSRFSQQISELADAIENNQTRQAMYLSEKVILEYGTHVITSIDAGATLVQEDYIKRSYVSDTNSERSSVSASAGINFFNMVNFNFGSKETEQTSETLTYQQNITYSLVQSHGGALFYQGITMQKWQESTQNHLVAIDRSGLPIHYFLNPAVFPDLPVPTLHKLAFSVQKAAERYYNINTTPGCTDQSSQNFNFQANVNDTSCEGPVTNLTFGGVYQTCTPESPDGNVICDEFAQRNPDTGDFTCRQPYSATRLHSENVQQGYNNYECHEECHSCWLILDCCHQVCGNVYYVRQAQIDTYWCSTSQTVPENTGYLFGGLFGPSLQNPQTKSHDCPANYFEQVFLTNGMRICLSNDYEAGTISSVPFGGLFSCQSGNPQAGNQYRCPPQYSQHLATISDGCQVLYCVQSGVFTGGQLKPVHLPPFTKPPLINMMATNTVAVMTEGDKAWMRVGGTKKWRVANLGEVSRMAKLIDASSTQMSGGEKAGVACGVMTLVAIVVAGIVILMKRRRKFSHFSFKRGYEEIQHDGQSTVEIEREQQNTNENPTQPLLP
Protein: Nuclear receptor subfamily 3 group C member 1 (D6RDA9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSAS
Protein: Chloride channel protein 2 (ClC-2) (P51788)
Organism: Homo sapiens (Human)
Function: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22405205, ECO:0000269|PubMed:23707145, ECO:0000269|PubMed:29403011, ECO:0000269|PubMed:36964785, ECO:0000269|PubMed:38345841}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:16155254}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:P35525}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P35525}. Note=Sorting to the basolateral membrane is mediated by AP-1 clathrin adapter (PubMed:16155254). Localizes at axon initial segments and dendritic shaft and spikes. Colocalizes with HEPACAM and GFAP at astrocyte end-foot in contact with brain capillaries and other glial cells (By similarity) (PubMed:22405205, PubMed:23707145). {ECO:0000250|UniProtKB:P35525, ECO:0000250|UniProtKB:Q9R0A1, ECO:0000269|PubMed:16155254, ECO:0000269|PubMed:22405205, ECO:0000269|PubMed:23707145}.
Interaction partners:
- EF-hand domain-containing protein 1
- Voltage-dependent T-type calcium channel subunit alpha-1H
- Gamma-aminobutyric acid receptor subunit gamma-2
- Gamma-aminobutyric acid receptor subunit alpha-1
- Voltage-dependent L-type calcium channel subunit beta-4
- Calcium-activated potassium channel subunit beta-3
- Gamma-aminobutyric acid receptor subunit delta
- Sodium channel protein type 1 subunit alpha
- Sodium channel regulatory subunit beta-1
Sequence:
MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ
Protein: Uncharacterized protein (Q586P3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- NADH dehydrogenase subunit NI8M
- NADH-ubiquinone oxidoreductase complex I subunit
- Uncharacterized protein
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NB-ARC domain-containing protein
- Adrenodoxin reductase, putative
- NADH-ubiquinone oxidoreductase complex I subunit
- Peptidyl-prolyl cis-trans isomerase
Sequence:
MKRFGIWTRPSLGRRSFYAGLDDSRVMRLRRSNTTLNKPRGRDAFSLAFEKRIHLLPLTQVGDLYGLPVPPSAPGESSGGAAEETIRVLVVDLLLLEDVESLISFPASNPLYYEDWPTVSDNSEGEVPSDRRSGISSSLALGESGFSLPSSNKRHLRQYGDTTLLRNSFVREAAHGVSAQFHTAICINPFIDVDRFRREEAQVEMISAYRNILYEAAEVPDGRADVIRIPALCCDTCGPRFYHEIGKLNQQSLIKGFHRIGSEAKETLMLNPKFIVEVYVPLPFLQQFQRAFLEDAWETPESTLNPGRTALYPGLAPPRSLLPLEGWIGKRPELVEAIETEGRSLMSGVKYSLDGKPIEEREVLAELRVFGREKEQEEMLKREEETATQQGLEVAPNGNTVAPLRAGIDQN
Protein: Proteinaceous RNase P 2 (EC 3.1.26.5) (Q680B9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Preferentially binds precursor tRNAs containing short 5' leaders and 3' trailers. Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA).
Subcellular location: Nucleus {ECO:0000269|PubMed:20473316}.
Interaction partners:
- Ribonucleases P/MRP protein subunit POP1
- Protein GAMETOPHYTE DEFECTIVE 1
- Proteinaceous RNase P 1, chloroplastic/mitochondrial
- Proteinaceous RNase P 3
- Probable ribonuclease P/MRP protein subunit POP5
- Uncharacterized mitochondrial protein AtMg01280
- Pentatricopeptide repeat-containing protein At5g04810, chloroplastic
- Pentatricopeptide repeat-containing protein At3g06430, chloroplastic
- Putative E3 ubiquitin-protein ligase ORTHRUS 4
Sequence:
MAASDQHRSRRHDESSSRPNKKKKVSRNPETNLLFNLNSCSKSKDLSAALALYDAAITSSEVRLSQQHFQTLLYLCSASITDISLQYLAIDRGFEIFDRMVSSGISPNEASVTSVARLAAAKGNGDYAFKVVKEFVSVGGVSIPRLRTYAPALLCFCEKLEAEKGYEVEEHMEAAGIALEEAEISALLKVSAATGRENKVYRYLHKLREYVGCVSEETLKIIEEWFCGEKAGEVGDNGIGSDVGMLREAVLNNGGGWHGHGWVGEGKWTVKKGNVSSTGRCLSCSEQLACVDTNEVETQKFVDSLVALAMDRKTKMNSCETNVVFSEFQDWLEKHGDYEAIVDGANIGLYQQNFVDGSFSLSQLESVMKELYRESGNNKWPLILLHKRRVKTLLENPTHRNLVEEWISNGVLYATPPGSNDDWYWLYAAAKLKCLLVTNDEMRDHIFELLGSTFFQKWKERHQVRYTFVKGNLKLEMPSPFSVVIQESEKGSWHFPVSCENNEESSRTWMCISRQSILDSPKSNGKIP
Protein: Cytochrome P450 2C54 (EC 1.14.14.1) (CYPIIC54) (Q6XVG2)
Organism: Mus musculus (Mouse)
Function: Metabolizes arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid (HETE).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15102943}; Peripheral membrane protein {ECO:0000269|PubMed:15102943}. Microsome membrane {ECO:0000269|PubMed:15102943}; Peripheral membrane protein {ECO:0000269|PubMed:15102943}.
Interaction partners:
- UDP-glucuronosyltransferase
- Cytochrome P450 1A2
- Cytochrome P450 2C50
- Cytochrome P450 2C37
- Cytochrome P450 2U1
- Cytochrome P450 2E1
- Cytochrome P450 3A25
- Cytochrome P450 2A12
- Epoxide hydrolase 1
- Estradiol 17 beta-dehydrogenase 5
Sequence:
MDPILVLVLTLSCLFLLSLWRQSYERGKLPPGPTPLPIIGNILQIDVKDICQSFTNLSRVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGDVFAGRGRLPVFDKATNGMGIGFSNGSVWKNTRHFSLMTLRNLGMGKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLLEKLDEISKILSTPWLQVCNTFPALLDYCPGSHNQFFKNYAYIKNFLLEKIREHKESLDVTIPRDFIDYFLIKGAQEDDNHPLKNNFEHLAITVTDLFIGGTESMSTTLRYALLLLLKYPHVTAKVQEEIEHVIGKHRRPCMQDRSHMPYTNAMIHEVQRFIDLVPNNLPHEVTCDIKFRNYFIPKGTTVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFKKSDYFMPFSTGKRICAGEGLARMELFLFLTSILQNFNLKPLVHPKDIDITPMLIGLGSVPPAFQLCFIPS
Protein: Glutathione synthetase (GSH-S) (EC 6.3.2.3) (Q6FUT4)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Glutamate--cysteine ligase
- Glutathione hydrolase
- Glutathione reductase
- Candida glabrata strain CBS138 chromosome C complete sequence
- Protein URE2
- glutathione-specific gamma-glutamylcyclotransferase
- Candida glabrata strain CBS138 chromosome A complete sequence
- Serine hydroxymethyltransferase, cytosolic
- Serine hydroxymethyltransferase, mitochondrial
- glutamate-5-semialdehyde dehydrogenase
Sequence:
MTEPIVPQALTNEELEKQILPETYQWALSNGLLMYPPDFQLTQAQIAPFTLYPTPIARKNFEEAIEVQQSFNELYAEISRDQGEHWLSQETEKLAHSDEGFTGKLWDLYKSVRNEGIAQKLRLGIFRSDYLIDKNIDQIKQVEFNTVSVSFVGFSTRVGEVHKYLNDSGAYGKSSYADKDIPVPTSVQEMTKSFADAFQKYDALNDEKKIILMVVQRGERNVFDQRIIEYSLQKDYGIRVIRMTFDDIISRLTSDNADKNRLFFKETGDEIAIVYYRTGYTTTDYQNEQDWEARKFLEKSYAIKAPDLLTQLSGAKKIQQLLTDDNILSQFVKSENSRRALQKTFVKIYPLDDSELGNIGKKLAFDEPHRFVLKPQREGGGNNVYKEDIPSFLSTIGESKWDAYILMEIIDPLPYENNVIIRGNEIFKESIISELGIYGSILFDDEKIHFNRNSGWLLRSKFTTSNEGGVAAGFGCLDSVVMY
Protein: Toxin RelE3 (Q9A4F4)
Organism: Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15) (Caulobacter crescentus)
Function: Toxic component of a type II toxin-antitoxin (TA) system. Its toxic effect is neutralized by coexpression with cognate antitoxin RelB3 but no other ParD or RelB antitoxin.
Interaction partners:
- Uncharacterized protein
- Antitoxin RelB3
Sequence:
MKSVELGPRARRDLTKLRRWLLNRAPSAADRAIDLILSRAEQLAQHSDLGRRKSQNMRELYVSFGAHGYVLQYRVYPDAVVIARIRHSLERR
Protein: Morphogenesis protein 1 (Gene product 13) (gp13) (Protein p13) [Includes: Lysozyme-like glycosidase (EC 3.2.1.-); Probable metalloendopeptidase (EC 3.4.-.-)] (P15132)
Organism: Bacillus phage phi29 (Bacteriophage phi-29)
Function: May serve as a plug to restrain the highly pressurized packaged genome and thus would be the first virion protein to contact the host cell wall, degrading the peptidoglycan layer and thereby facilitating viral genome entry into the host bacteria. Acts probably as a multifunctional enzyme that degrades N-acetylglucosamine polymers (in vitro) and cleaves the peptide cross-links of the host cell wall. Essential for the tail assembly.
Subcellular location: Virion {ECO:0000269|PubMed:18394643, ECO:0000269|PubMed:18606992}. Note=Located at the distal tip of the tail knob.
Interaction partners:
Sequence:
MVYVSNKYLTMSEMKVNAQYILNYLSSNGWTKQAICGMLGNMQSESTINPGLWQNLDEGNTSLGFGLVQWTPASNYINWANSQGLPYKDMDSELKRIIWEVNNNAQWINLRDMTFKEYIKSTKTPRELAMIFLASYERPANPNQPERGDQAEYWYKNLSGGGGGGLQLAQFPMDIINISQGENGSFSHKGTLCIDFVGKTEKYPYYAPCDCTCVWRGDASAYLAWTSDKEVMCADGSVRYITWVNVHESPLPFDVGKKLKKGDLMGHTGIGGNVTGDHWHFNVIDGKEYQGWTKKPDSCLAGTELHIYDVFAVNNVEIINGNGYDWKTSDWQDGDGGDGDDDNDNNKTKDLITLLLSDALHGWKA
Protein: SEC14-like protein 4 (Tocopherol-associated protein 3) (Q9UDX3)
Organism: Homo sapiens (Human)
Function: Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
Interaction partners:
Sequence:
MSSRVGDLSPQQQEALARFRENLQDLLPILPNADDYFLLRWLRARNFDLQKSEDMLRRHMEFRKQQDLDNIVTWQPPEVIQLYDSGGLCGYDYEGCPVYFNIIGSLDPKGLLLSASKQDMIRKRIKVCELLLHECELQTQKLGRKIEMALMVFDMEGLSLKHLWKPAVEVYQQFFSILEANYPETLKNLIVIRAPKLFPVAFNLVKSFMSEETRRKIVILGDNWKQELTKFISPDQLPVEFGGTMTDPDGNPKCLTKINYGGEVPKSYYLCEQVRLQYEHTRSVGRGSSLQVENEILFPGCVLRWQFASDGGDIGFGVFLKTKMGEQQSAREMTEVLPSQRYNAHMVPEDGSLTCLQAGVYVLRFDNTYSRMHAKKLSYTVEVLLPDKASEETLQSLKAMRPSPTQ
Protein: Gastrotropin (GT) (14 kDa bile acid-binding protein) (Fatty acid-binding protein 6) (I-BABP) (Ileal lipid-binding protein) (ILBP) (Intestinal 15 kDa protein) (I-15P) (P80020)
Organism: Rattus norvegicus (Rat)
Function: Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:2029905, ECO:0000269|PubMed:8197128}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P50119}; Cytoplasmic side {ECO:0000250|UniProtKB:P50119}.
Interaction partners:
- Fatty acid-binding protein, heart
- Fatty acid-binding protein, brain
- Fatty acid-binding protein 5
- Fatty acid-binding protein, adipocyte
- Fatty acid-binding protein, liver
- Bile acid receptor
- Fatty acid-binding protein, intestinal
- Ileal sodium/bile acid cotransporter
- Solute carrier family 51 member A
- Bile salt export pump
Sequence:
MAFTGKYEFESEKNYDEFMKRLGLPDEVIERGRNFKIITEVQQDGENFTWSQSYSGGNIMSNKFTIGKECEMQTMGGKKFKATVKMEGGKVVADFPNYHQTSEVVGDKLVEISTIGDVTYERVSKRVA
Protein: GH10112p (Necrotic) (Q7JWX3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Serine protease persephone
- Spaetzle-processing enzyme
- NF-kappa-B inhibitor cactus
- Serine protease inhibitor 42Dd
Sequence:
MASKVSILLLLTVHLLAAQTFAQELIAWQRQQQQQQQQQLQLQQQLLLQQQQHQRNPRPELGLRSLPGNPWTQNNQEAISDVVAVDLTKREPVTPPPNRPPPVFSYMDRFSSELFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEFSKNAMAVAQDFESVIKYKKHLEGADLTLATKVYYNRELGGVNHSYDEYAKFYFSAGTEAVDMQNAKDTAAKINAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHEFATMDTSPYDFQHTNGRISKVAMMFNDDVYGLAELPELGATALELAYKDSATSMLILLPNETTGLGKMLQQLSRPEFDLNRVAHRLRRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVTKLMDQPVRVSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTEFVANRPFVFAVRTPASVLFIGHVEYPTPMSV
Protein: At4g16450 (NADH-ubiquinone oxidoreductase) (Q84W12)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Excitatory amino acid transporter
- Gamma carbonic anhydrase 2, mitochondrial
- At1g67350
- Uncharacterized protein At2g27730
- NADH dehydrogenase 1 beta subcomplex subunit 2
- Gamma carbonic anhydrase 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 1
- Transmembrane protein
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase 1 beta subcomplex subunit 3-A
Sequence:
MNTDITALEKAQYPVVDRNPAFTKVVGNFSTLDYLRFSTITGISVTVGYLSGIKPGIKGPSMVTGGLIGLMGGFMYAYQNSAGRLMGFFPNDGEVASYQKRGGFSK
Protein: Lysosomal cobalamin transport escort protein LMBD1 (LMBD1) (LMBR1 domain-containing protein 1) (Protein N90b) (Q8K0B2)
Organism: Mus musculus (Mouse)
Function: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2. Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NUN5}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NUN5}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:24078630}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:24078630}.
Interaction partners:
- Lysosomal cobalamin transporter ABCD4
- Cobalamin trafficking protein CblD
- Cyanocobalamin reductase / alkylcobalamin dealkylase
Sequence:
MAAAAAELVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWADANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDEDDASKCTQIKTALKYTLGFVVICALLLLVGAFVPLHLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLPARDRRALKQCEERLRTLRKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDAHKGNSTLAVPKRCDADAPKDQCTVTRTYIFLHKFWFFSAAYYFGNWAFLVVFLIGLIVSCCKGKKSVIEGVDEDSDLSDDEPSAYSA
Protein: ATP synthase F(0) complex subunit a (F-ATPase protein 6) (Proton-conducting channel, ATP synthase F(0) complex subunit a) (P00846)
Organism: Homo sapiens (Human)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein.
Interaction partners:
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase F
- Cytochrome b
- ATP synthase F
- NADH-ubiquinone oxidoreductase chain 4
- ATP synthase F
- ATP synthase F
- ATP synthase F
- NADH-ubiquinone oxidoreductase chain 5
- ATP synthase peripheral stalk subunit b, mitochondrial
Sequence:
MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLITTQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNLAMAIPLWAGTVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRLTANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLVSLYLHDNT
Protein: Uncharacterized protein (Q387B3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSNEVESSAAEPPAPDEATNVAGHRYILINNILCRTETSDGSFRPSDVFVGLDPPPRGTATLGSAAEDNCNHLSVGEFDPTAYVDSISKDCSIFNVFGVMSGGVLVDSESRGFIDFTDDMIFRPPLPPPVEGNDTHNEGSRDGQIRADGVVSLVSSIFPFNGLGTVDTPLPWPRSLPRLRSQRISYRLAAKTVHRMLSRCVGNVKCNKAVLVVLESYRIHRKLHSPQLTFLPNEIPFRFQWHGMTFRVKDGGAPKRFDANGNRTHEYRSPIGRINHMMDGKTGSAYSSFHAFTGLPKMAFRRYRESARRESRHRLENLADGYSRRLEMRIQNIVHPIREEMHIDENIEVVFRRRSGVHLWSAFQRYFTILGVSRCTSCNTPNCNAWYLDNDDKVDYPSALRKLEEDLKYRRTFNLSSSILADSWDWLLAKERGPLTERIRKIIKYARQIDAENKREVINTDKDLR
Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (X2JLM6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRVIAPRRSSTSAAGSGSLYGTSAVGTSSGSTTSSNSTSGSHHISITGSGAVDRTSGGAATNGYSRISSSYDRGSSLSKWLPTSSGGSNSSGYGSSYYPTSYSTFSANSGSSSASYAPRSSVQRSSVGTTSSTSYMSGGSGSSSSAYRTSSYLSGSSYDSPTYSRYGTLARSGTGSSSTARSVLPPMTPTSSRYWDRDSGTSRSSIGTSSALNSSSLKHNSDDGYKTASSSRDEKSEGLCGLRNIGNTCFMNSVIQCLSHTQELTRFLRSHHGSRSLSTKDQQILHEFAKLIQEMWTANVHTVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSALNSGVKGETLNIDDNLSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPLPSSSRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFSETRWSKLSNIVEFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSSAYILFYERT