wanglab/gogpt-training-data huggingface dataset:
Protein: Oxysterol-binding protein 1 (OSBPa) (Q8MPQ7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May play a role in the regulation of the slug-fruiting body switch.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12220630}. Note=Localizes predominantly to the cell periphery, but is also found in the perinuclear region in some cells.
Interaction partners:
Sequence:
MGKKDKNVSVEEEVDEAEIEKLAAENANKPAPQLTKEDLDAMDDAEPGTSRLALIGKMIKKVSIGTDISNISMPGSFILAKSTLSYFSDNFSSFFGELLKANKIDNELERMLQVQRYLFTTLKETEDTTRKPLNPILGETWQANIHVKDGDGNDVTDNYFFAEQISHHPPISSSTVYNKKEGVNCTFCLPVRSQFMGTYVKISFEGESHITFEKYDEKFTFVAPPMAIRIFRSFSEYVGKGILKSDKNDYLIKSTYTSKPLFGGVYNGFESKVYKGKEKLYKIKGTWSGDMKITNLKTNETTPFFTRPTESAKVVFPDDGNTLPTDSSVVWKGVFDASKKDDVKGMSQEKVKVEEEQRKLAHHRKNADEWKPVHFNKIDGRWQLVNLKD
Protein: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (EC 3.6.1.17) (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Ap4A hydrolase) (Ap4Aase) (Diadenosine tetraphosphatase) (P49776)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.
Interaction partners:
- Probable hydrolase nit2
- Hydrolase C26A3.11
- Zinc-regulated GTPase metalloprotein activator 1
- Ferrochelatase, mitochondrial
Sequence:
MPKQLYFSKFPVGSQVFYRTKLSAAFVNLKPILPGHVLVIPQRAVPRLKDLTPSELTDLFTSVRKVQQVIEKVFSASASNIGIQDGVDAGQTVPHVHVHIIPRKKADFSENDLVYSELEKNEGNLASLYLTGNERYAGDERPPTSMRQAIPKDEDRKPRTLEEMEKEAQWLKGYFSEEQEKE
Protein: BRCA2-interacting transcriptional repressor EMSY (Q8BMB0)
Organism: Mus musculus (Mouse)
Function: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (By similarity). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (By similarity). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:14651845}. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.
Interaction partners:
- Breast cancer type 2 susceptibility protein homolog
- PHD finger protein 12
- Chromobox protein homolog 1
- Paired amphipathic helix protein Sin3a
- Lysine-specific demethylase 5A
- Mortality factor 4-like protein 1
- Paired amphipathic helix protein Sin3b
- Zinc finger protein 131
Sequence:
MPVVWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAHKMNLSLYLGERPSYSMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTVTANAVANAAVQHNASLPVPAETASKDGVSCSDEDEKPRKRRRTNSSSSSPVVLKEVPKAVVPVSKTITVPVSGSPKMSNIMQSIANSLPPHMSPVKITFTKPSTQTTNTTTQKVIIVTTSPSSTFVPNILSKSHNYAAVTKLVPTSVIASTTQKPPVVITASQASLVTSSSNGNSSSTSSPISSTVAVTTVVSSTPSVVMSTVAQGVSTSAIKVASTRLPSPKSLVSGPTQILAQFPKQHQQSPKQQLQQVQQQTQQPVAQPSSVSQQQQPQQSALPPGIKPTIQIKQESGVKIITQQVQPSKILPKPVTATLPTSSNSPIMVVSSNGAIMTTKLVTTPTGTQATYTRPTVSPSLGRVATTPGAATYVKTTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTIPMTSKPNVIVVQKTTGKGTTIQGLPGKNVVTTLLNAGGEKTLQTVPAGAKPAIITATRPITKMIVTQPKGIGSAVQPAAKIIPTKIVYGQQGKTQVLIKPKPVTFQATVVSEQTRQLVTETLQQASRVADASNSSAQEGKEEPQGYTDSSSSSTESSQSSQDSQPVVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTIKALLELQQTTVKEKLESKPRQPTIDLSQMAVPIQMTQEKRHSPESPSIAVVESELVAEYITTVSHRSQPQQPSQPQRTLLQHVAQSQTATQTSVVVKSIPASSPGAITHIMQQALSSHTAFTKHSEELGTEEGEVEEMDTLDPQTGLFYRSALTQSQSTKQQKLSQPQLEQTQLQVKTLQCFQTKQKQTIHLQADQLQHKLTQMPQLSIRHQKLNPLQQEQAQPKPDAQHTQHTVVAKDRQLPTLMAQPPQTVVQVLAVKTTQQLPKLQQAPNQPKIYVQPQTPQSQMALPSSEKQPASQVEQPIITQGSSVTKITFEGRQPPTVTKITGGSSVPKLTSPVTSISPIQASEKTAVSDILQMSLMEAQIDTNVEHMVVDPPKKALATNVLTGEAGALPSTHVVVAGMTKCRESCSSPSAVGPPLTTRKIEAAGVPTTGQFMRIQNVGQKKAEESPTEIIIQAIPQYAIPCHSSSNVVVEPSGLLELNNFTSQQLDDDETAMEQDIDSSTEDGTEPSPSQSAVERS
Protein: Probable acyltransferase YihG (EC 2.3.-.-) (P32129)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MANLLNKFIMTRILAAITLLLSIVLTILVTIFCSVPIIIAGIVKLLLPVPVIWRKVSRFCDFMMYCWCEGLAVLLHLNPHLQWEVHGLEGLSKKNWYLLICNHRSWADIVVLCVLFRKHIPMNKYFLKQQLAWVPFLGLACWSLDMPFMKRYSRAYLLRHPERRGKDVETTRRSCEKFRLHPTTIVNFVEGSRFTQEKHQQTHSTFQNLLPPKAAGIAMALNVLGKQFDKLLNVTLCYPDNNRQPFFDMLSGKLTRIVVHVDLQPIADELHGDYINDKSFKRHFQQWLNSLWQEKDRLLTSLMSSQRQNK
Protein: Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) (P9WI55)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00209}. Secreted {ECO:0000305|PubMed:27097115}. Host cell surface {ECO:0000269|PubMed:27097115}.
Interaction partners:
- ATP synthase subunit b-delta
- ATP synthase subunit c
- ATP synthase subunit alpha
- ATP synthase subunit b
- ATP synthase gamma chain
- Polyphosphate kinase
- ATP synthase subunit beta
- GDP-polyphosphate phosphotransferase
- ATP synthase subunit a
- ATP synthase epsilon chain
Sequence:
MQFDVTIEIPKGQRNKYEVDHETGRVRLDRYLYTPMAYPTDYGFIEDTLGDDGDPLDALVLLPQPVFPGVLVAARPVGMFRMVDEHGGDDKVLCVPAGDPRWDHVQDIGDVPAFELDAIKHFFVHYKDLEPGKFVKAADWVDRAEAEAEVQRSVERFKAGTH
Protein: Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) (Rostral cerebellar malformation protein) (O08747)
Organism: Mus musculus (Mouse)
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion. Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC. Also involved in corticospinal tract axon guidance independently of DCC. Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:22405201}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:O95185}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q761X5}. Cell projection, dendrite {ECO:0000269|PubMed:22685302}. Cell projection, axon {ECO:0000269|PubMed:22685302}. Cell projection, growth cone {ECO:0000269|PubMed:22685302, ECO:0000269|PubMed:28483977}. Cell projection, lamellipodium {ECO:0000269|PubMed:28483977}. Cell projection, filopodium {ECO:0000269|PubMed:28483977}.
Interaction partners:
- Netrin-1
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L2
- Netrin receptor DCC
- Proto-oncogene tyrosine-protein kinase Src
- Focal adhesion kinase 1
- Tyrosine-protein phosphatase non-receptor type 11
- Neogenin
- Netrin-3
Sequence:
MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDEFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPAEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQAAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPSTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY
Protein: Tetraspanin-2 (Tspan-2) (Q9JJW1)
Organism: Rattus norvegicus (Rat)
Function: May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MGRFRGGLRCIKYLLLGFNLLFWLAGSAVIAFGLWFRFGGTIKDLSSEEKSPEYFYVGLYVLVGAGALMMAVGFFGCCGAMRESQCVLGSFFTCLLVIFAAEVTTGVFAFIGKDVAIRHVQSMYEEAYSDYVRDRGRGNGTLITFHSAFQCCGKESSEQVQPTCPKELPGHKNCIDKIETIISVKLQLIGIVGIGIAGLTIFGMIFSMVLCCAIRNSRDVI
Protein: ATP synthase subunit beta, chloroplastic (EC 7.1.2.2) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta) (P19366)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01347}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01347}.
Interaction partners:
- ATP synthase epsilon chain, chloroplastic
- ATP synthase subunit b, chloroplastic
- ATP synthase subunit alpha, chloroplastic
- ATP synthase subunit a, chloroplastic
- ATP synthase subunit delta, chloroplastic
- ATP synthase gamma chain 1, chloroplastic
- ATP synthase subunit d, mitochondrial
- ATP synthase subunit c, chloroplastic
- ATP synthase gamma chain 2, chloroplastic
- ATP synthase subunit alpha
Sequence:
MRTNPTTSNPEVSIREKKNLGRIAQIIGPVLDVAFPPGKMPNIYNALVVKGRDTLGQEINVTCEVQQLLGNNRVRAVAMSATEGLKRGMDVVDMGNPLSVPVGGATLGRIFNVLGEPVDNLGPVDTRTTSPIHKSAPAFIELDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEQNLAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGTLQERITSTKKGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQQVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFNLILSGEFDSLPEQAFYLVGNIDEATAKATNLEMESKLKK
Protein: Urocanate hydratase (Urocanase) (EC 4.2.1.49) (Imidazolonepropionate hydrolase) (Q9HU83)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00577}.
Interaction partners:
- Probable histidine/phenylalanine ammonia-lyase
- Histidine ammonia-lyase
- Imidazolonepropionase
- Formimidoylglutamate deiminase
- Histidine utilization repressor
- Probable transporter
- N-formylglutamate deformylase
- Formimidoylglutamase
- Probable binding protein component of ABC transporter
- Quaternary amine transport ATP-binding protein
Sequence:
MTTPSKFRDIEIRAPRGTTLTAKSWLTEAPLRMLMNNLDPEVAENPRELVVYGGIGRAARNWECYDRIVETLKQLNDDETLLVQSGKPVGVFKTHANAPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYDGNLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLRSRYVDEQAKDLDDALARIQRYTAEGKAISIALLGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPAGWSWEEYRDRAQTDPAAVVKAAKQSMAVHVRAMLAFQQQGVPTFDYGNNIRQMAKEEGVANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPQDIYKTDAKVKQLIPDDAHLHRWLDMARERISFQGLPARICWVGLGLRAKLGLAFNEMVRTGELSAPIVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVIVCDGSDEAAERIARVLTNDPGTGVMRHADAGYQVAIDCAKEQGLNLPMITAQR
Protein: Inheritance of peroxisomes protein 1 (Q03694)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for peroxisome inheritance.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15928207}; Peripheral membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15928207}.
Interaction partners:
- Peroxisomal biogenesis factor 3
- Inheritance of peroxisomes protein 2
- Peroxisomal membrane protein import receptor PEX19
- Peroxisomal membrane protein PMP27
- Peroxisomal membrane protein PEX30
- Peroxisomal membrane protein PEX17
- Myosin-2
- Peroxisomal membrane protein PEX25
Sequence:
MVLSRGETKKNSVRLTAKQEKKPQSTFQTLKQSLKLSNNKKLKQDSTQHSNDTNKSVKAKKNGTSSKKTGTQRKRISTQRFSLFTYGNVQVMNSFVPIHNDIPNSSCIRRNSQVSANNVTESSGVFFNDTQSQDSQNTIKLKPTSLMAKGPIEIYQICTGFDKLKENIAPFQKSSKASSHDGHVVNYLSIGRHGDIVHPVLPKLQITRLNGAGFKYFISFYNPERYWEIEFLPLISQSQSELENSVKAFENVISKICQFSHINEGATIGNNESLSDKFKLPPTSDIEPPNTEIINNDDDNDDDDDNYDDDDLNYLLDEEYEQGCTDNSFSVISNTCSNLNASFLYPSDPTDAVSISINEAFKNAIRRTAPVLNIPIAAPSIHSKQQNKRYSSYPFIDSPPYLQDRHRRFQRRSISGLGDL
Protein: Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease) (O54862)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation.
Subcellular location: Membrane {ECO:0000250|UniProtKB:O43462}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O43462}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O43462}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MIPVSLVVVVVGGWTAVYLADLVLKSSVYFKHSYEDWLEKNGLSISPFHIRWQTSVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSSSSSSSSSSSSSSSSIHNEQVLQVVVPGINLPVNQLTYFFAAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRTNKDCKTSSSSSFCIVPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVIVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR
Protein: Vacuolar proton pump subunit B (V-ATPase subunit B) (Vacuolar proton pump subunit B) (A0A140VK65)
Organism: Homo sapiens (Human)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000256|ARBA:ARBA00029434}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029434}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00037827}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037827}. Melanosome {ECO:0000256|ARBA:ARBA00004223}.
Interaction partners:
Sequence:
MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH
Protein: SLH domain protein (F4JA39)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MSSFSVKKSPNSSFLFPKITPLLIRHRLTLPLLVPPHKPPRFRIVASLSGTSWVSQASQDKYGGWALAEDETPSPHSITKKKWRNVVITGVGSSLAVVLATIAYFSISRKGFRFSFSNLLQYQNVELDQNDNEESETLFNDENNSPSEANSESVDYVSDNVDSTSTGKTHRVATPVAVDAAQQEAIAVLKKLKIYEDDIVADELCTKREYARWLVRSNSLLERNPMHMIVPAVALAGSSIPAFDDINTSDPDFEYIQALAEAGITSSKLSGEDSRNDLGNSNFNPESFVSRLDLVNWKAQLECGFHPEIMEEISRTKVDYIDTKNINPDMALGFFLDFLMGDKSTIRNVFGRIKRFQPNRPVTKAQAAVALTSGKMVKAITAELSRLEAESLSQKAETEEIRSELLEKGEIRQFWDEKIQAERSRGFEMEELYLSRVNEVEEEKTTQEKWSAERLKEKAAIDCQKQLLNSLTEEIDEMSQRLISDKSVYLTEHSKLQEMLSDLQSKLESLIDKRSILEAEVEALRILRSWIEDEGKASQARAKVLEEAGRRWKWNDNA
Protein: Insulin-like peptide 5 (dILP5) (Insulin-related peptide 5) [Cleaved into: Insulin-like peptide 5 A chain; Insulin-like peptide 5 B chain] (Q7KUD5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Neural/ectodermal development factor IMP-L2
- Insulin-like peptide 3
- Insulin-like receptor
- Insulin-like peptide 2
- Insulin-like peptide 6
- Insulin-like peptide 1
- Insulin-like peptide 7
- Insulin-like peptide 4
- Insulin receptor substrate 1
- Death-associated inhibitor of apoptosis 2
Sequence:
MMFRSVIPVLLFLIPLLLSAQAANSLRACGPALMDMLRVACPNGFNSMFAKRGTLGLFDYEDHLADLDSSESHHMNSLSSIRRDFRGVVDSCCRKSCSFSTLRAYCDS
Protein: Vacuolar cation/proton exchanger 3 (Ca(2+)/H(+) antiporter CAX3) (Ca(2+)/H(+) exchanger 3) (Protein CATION EXCHANGER 3) (Q93Z81)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase (By similarity). Involved in ion homeostasis in association with CAX1.
Subcellular location: Vacuole membrane {ECO:0000305|PubMed:16055687}; Multi-pass membrane protein {ECO:0000305|PubMed:16055687}. Note=Tonoplast.
Interaction partners:
- Cation/calcium exchanger 5
- Putative calcium-transporting ATPase 11, plasma membrane-type
- Putative calcium-transporting ATPase 13, plasma membrane-type
- Cation/calcium exchanger 3
- CAX-interacting protein 4
- Vacuolar cation/proton exchanger 1
- Cation/calcium exchanger 1
- Calcium-transporting ATPase 4, endoplasmic reticulum-type
- Alpha carbonic anhydrase 2
- Calcium-transporting ATPase 10, plasma membrane-type
Sequence:
MGSIVEPWAAIAENGNANVTAKGSSRELRHGRTAHNMSSSSLRKKSDLRLVQKVPCKTLKNILSNLQEVILGTKLTLLFLAIPLAILANSYNYGRPLIFGLSLIGLTPLAERVSFLTEQLAFYTGPTVGGLLNATCGNATELIIAILALANNKVAVVKYSLLGSILSNLLLVLGTSLFFGGIANIRREQRFDRKQADVNFFLLLMGLLCHLLPLLLKYAATGEVSTSMINKMSLTLSRTSSIVMLIAYIAYLIFQLWTHRQLFEAQQDDDDAYDDEVSVEETPVIGFWSGFAWLVGMTIVIALLSEYVVDTIEDASDSWGLSVSFISIILLPIVGNAAEHAGAIIFAFKNKLDISLGVALGSATQISLFVVPLSVIVAWILGIKMDLNFNILETSSLALAIIITAFTLQDGTSHYMKGLVLLLCYVIIAACFFVDQIPQPNDLDVGLQPMNNLGEVFSA
Protein: Fezzik, isoform A (EC 1.-.-.-, EC 1.1.-.-) (Fezzik, isoform B) (Q9VY04)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Uncharacterized protein, isoform A
Sequence:
MSLDGGQNLNLDAAAIGPDPCGSVPATPGIGLWSGMVTILVQTLLSSQCLVSPASQWPVDYVGDLSQPYDFVVIGAGSAGSVVASRLSENPDWRVLVLEAGGDPPVESELPALFFGLQHTNFTWNYFTEPSDEACQAMKDGRCYWPRGKMLGGSGGVNAMLYVRGNRRDFDGWAAMGSTGWSYDQVMPFFEKSVTPQGNATHPKGYVTLKPFERKDNDIHQMIIDGGRELGQPYVERFQEGSDTGYSHVPGTVRQGQRMSTGKGYLGAVSKSRPNLHVVKNALVTKLDLDGETVKEVKFERAGVTHRVKVTKDVVISAGAIDSPALLLRSGIGPSKHLKELGIPVKLDLPGVGRNLQDHVLVPVFLRLDEGQGEPMTDQAALDSIYQYLIYRAGPLAAHSTASLVGFINTNASSDGAYPDTENHHMFFQRAHHASLELFTKGLSIQDQYTEVLQEYLKDSHLLCVFVLLSHPAARGELRLKSTDPKVPPILTSNYLTESEDVATLMRGIRYIESLEQTKAFQDHLAEIARIPIKECDQIENYRSEEYWRCYAKYFTVTCYHQSGTVKMGPDYDNEACVSQRLKVHGLENLRVADASIMPAVVSANTNAATVMIGERAAHFIQEDYQGEAVGANGGLWVPHMHADEF
Protein: Eukaryotic peptide chain release factor subunit 1 (Q803E5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- ATP-binding cassette sub-family E member 1
- Serine/threonine-protein kinase SMG1
- Eukaryotic translation termination factor 1a.
- FAU ubiquitin-like and ribosomal protein S30 fusion b
- FAU ubiquitin-like and ribosomal protein S30 fusion a ubiquitously expressed
- G1 to S phase transition 1
- Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
- Protein pelota homolog
- Ribosomal protein L7-like 1
- Regulator of nonsense transcripts 1
Sequence:
MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFVSNDKVNVAGLVLAGSADFKTELSQSDMFDPRLQAKVLKLVDISYGGENGFNQAIELSAEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYENLDTMRYVLRCHGENTTPENDEKILYLTPEQEKDKSHFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGFGGIGGILRYRVDFQGMEYQGDDDEFFDLDDY
Protein: Uncharacterized sugar kinase YdjH (EC 2.7.1.-) (P77493)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized protein YdjI
- Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjJ
- Uncharacterized HTH-type transcriptional regulator YdjF
- Putative metabolite transport protein YdjK
- Inner membrane metabolite transport protein YdjE
- NADH-specific methylglyoxal reductase
- Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjL
Sequence:
MDNLDVICIGAAIVDIPLQPVSKNIFDVDSYPLERIAMTTGGDAINEATIISRLGHRTALMSRIGKDAAGQFILDHCRKENIDIQSLKQDVSIDTSINVGLVTEDGERTFVTNRNGSLWKLNIDDVDFARFSQAKLLSLASIFNSPLLDGKALTEIFTQAKARQMIICADMIKPRLNETLDDICEALSYVDYLFPNFAEAKLLTGKETLDEIADCFLACGVKTVVIKTGKDGCFIKRGDMTMKVPAVAGITAIDTIGAGDNFASGFIAALLEGKNLRECARFANATAAISVLSVGATTGVKNRKLVEQLLEEYEG
Protein: beta-galactosidase (EC 3.2.1.23) (Lactase) (F4JCX1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Aldose 1-epimerase
- Aldose 1-epimerase
- Galactose mutarotase-like superfamily protein
- Galactose mutarotase
- Alpha-galactosidase 3
- Alpha-galactosidase 2
- Alpha-galactosidase 1
- Non-lysosomal glucosylceramidase
- Non-lysosomal glucosylceramidase
- Beta-galactosidase 17
Sequence:
MVSLATQMILPSENGYRVWEDQTLFKWRKRDPHVTLRCHESVQVSQGRVKILCDCIGALRYWYQRNNVDLTVSKSAVWNDDAVQAALDSAAFWVDGLPFVKSLSGYWKFFLAPKPANVPDKFYDAAFSDSDWNALQVPSNWQCHGFDRPIYTNVVYPFPNDPPYVPEDNPTGCYRTYFQIPKEWKDRRILLHFEAVDSAFFAWINGNPVGYSQDSRLPAEFEISDYCYPWDSGKQNVLAVQVFRWSDGSYLEDQDHWWLSGIHRDVLLLAKPKVFIADYFFKSKLADDFSYADIQVEVKIDNMQESSKDLVLSNFIIEAAIFDTKNWYNSEGFSCELSPKVANLKLNPSPSPTLGFHGYLLEGKLDSPNLWSAEQPNVYILVLTLKDTSGKVLDSESSIVGIRQVSKAFKQLLVNGHPVVIKGVNRHEHHPRVGKTNIEACMVKDLIMMKEYNINAVRNSHYPQHPRWYELCDLFGMYMIDEANIETHGFDLSGHLKHPAKEPSWAAAMLDRVVGMVERDKNHTCIISWSLGNEAGYGPNHSAMAGWIREKDPSRLVHYEGGGSRTSSTDIVCPMYMRVWDIIKIALDQNESRPLILCEYQHAMGNSNGNIDEYWEAIDNTFGLQGGFIWDWVDQGLLKLGSDGIKRWAYGGDFGDQPNDLNFCLNGLIWPDRTPHPALHEVKHCYQPIKVSLTDGMIKVANTYFFNTTEELEFSWTIHGDGLELGSGTLSIPVIKPQNSFEMEWKSGPWFSFWNDSNAGELFLTINAKLLNLTRSLEAGHLLSSTQIPLPAKGQIIPQAIKKTDTSITCETVGDFIKISQKDSWELMVNVRKGTIEGWKIQGVLLMNEAILPCFWRAPTDNDKGGGDSSYFSRWKAAQLDNVEFLVESCSVKSITDKSVEIEFIYLGSSASGSSKSDALFKVNVTYLIYGSGDIITNWFVEPNSDLPPLPRVGIEFHIEKTLDRVEWYGKGPFECYPDRKAAAHVAIYEHNVGDMHVPYIVPGENGGRTDVRWVTFRNKDGVGIYASTYGSSSLMQMNASYYTTGELHRATHEEDLIKGQNIEVHLDHKHMGLGGDDSWTPCVHDKFLIPPAQYSFSLRLCPITASTSGLNIYKDQLPC
Protein: Glucosamine-6-phosphate deaminase 1 (GlcN6P deaminase 1) (EC 3.5.99.6) (Glucosamine-6-phosphate isomerase 1) (Protein oscillin) (P46926)
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O88958}.
Interaction partners:
- N-acetylglucosamine-6-phosphate deacetylase
- N-acetylglucosamine-6-phosphate deacetylase
- Glucosamine 6-phosphate N-acetyltransferase
- Glucosamine-6-phosphate deaminase 2
- Glutamine--fructose-6-phosphate aminotransferase 2
- Glutamine--fructose-6-phosphate aminotransferase 1
- Glucose-6-phosphate isomerase
- GDH/6PGL endoplasmic bifunctional protein
- Hexokinase-1
- Mannose-6-phosphate isomerase
Sequence:
MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQSSKKPYSD