wanglab/gogpt-training-data huggingface dataset:
Protein: Rab escort protein 1 (AthREP) (Q8LLD4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component composed of the alpha subunit RGTA and the beta subunit RGTB (Probable). Preferentially binds the GDP-bound form of Rab and stimulates geranylgeranylation of various Rab GTPases in vitro.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15854662}.
Interaction partners:
- Geranylgeranyl transferase type-2 subunit beta 1
- Geranylgeranyl transferase type-2 subunit beta 2
- Geranylgeranyl transferase type-2 subunit alpha 1
- Geranylgeranyl transferase type-2 subunit alpha 2
- Protein prenylyltransferase superfamily protein
- At3g14910
- Ras-related protein RABF2a
- Ras-related protein RABF1
- Ras-related protein RABA2a
- Ras-related protein RABE1a
Sequence:
MIDIPPYPPLDPSNYDLIVVGTGVSESVLAAAASSSGSSVLHLDPNPFYGSHFASLSLPDLTSFLHSNSVSPPPSPSSPPLPPSNNHDFISVDLVNRSLYSSVEISSFESEILEEHSRRFNVDLAGPRVVFCADESINLMLKSGANNYVEFKSIDASFVGDSSGELRNVPDSRAAIFKDKSLTLLEKNQLMKFFKLVQSHLASSTEKDDSTTVKISEEDMESPFVDFLSKMRLPPKIKSIILYAIAMLDYDQDNTETCRHLLKTKEGIDRLALYITSMGRFSNALGALIYPIYGQGELPQAFCRRAAVKGCIYVLRMPITALLLDKETGGYKGVRLASGQEIFSQKLILDPCVTVGLESLSSLTDQQNETLSVLVPKSMINKEKIARGVCVIRGSVKANVSNALVVYPPKSLFPEQLTAIRVLQLGSGLAVCPADMHVLYLSTLCDNDDQGIKALLSAMSNLISLPVPENRQSDSVVENDTSETKPILLWRALYVQELVKGEFGGTISSMPSPDGNLNYNEIVESAVKLYEKLMGSEELFKEETSPAENTTEEENDGGVEIED
Protein: Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) (Q9H792)
Organism: Homo sapiens (Human)
Function: Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102}. Cell junction, focal adhesion {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:35687021}. Note=Colocalizes with F-actin in serum-rich medium (PubMed:20534451). Actin colocalization is reduced during serum starvation (PubMed:20534451). {ECO:0000269|PubMed:20534451}.
Interaction partners:
- SHC-transforming protein 1
- Adapter molecule crk
- Eukaryotic translation initiation factor 5A-1
Sequence:
MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDPEKAPITHGNVKTNANHSNNHRIRNTGNFRPPVAKKPTIAVKPTMIVADGQSICGELSIQEHCENKPVIIGWNRNRAALSQKPLNNNNEDDEGISHVPKPYGNNDSAKKMSDNNNGLTEVLKEIAGLDTAPQIRGNETNSRETFLGRINDCYKRSLERKLPPSCMIGGIKETQGKHVILSGSTEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEIRMRGQPRFANFRANTLSPVRFFVDKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSVVSYGQGSIQSMVSSDSTSPDSSLTEESRSETASSLSQKICNGGLSPGNPGDSKDMKEIEPNYESPSSNNQDKDSSQASKSSIKVPETHKAVLALRLEEKDGKIAVQTEKEESKASTDVAGQAVTINLVPTEEQAKPYRVVNLEQPLCKPYTVVDVSAAMASEHLEGPVNSPKTKSSSSTPNSPVTSSSLTPGQISAHFQKSSAIRYQEVWTSSTSPRQKIPKVELITSGTGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPTYARSSKNAIKVPIVINPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESKVPDNTTSKTTDCLQTKGFSNSTEHKRGSVAQKVQEFNNCLNRGQSSPQRSYSSSHSSPAKIQRATQEPVAKIEGTQESQMVGSSSTREKASTVLSQIVASIQPPQSPPETPQSGPKACSVEELYAIPPDADVAKSTPKSTPVRPKSLFTSQPSGEAEAPQTTDSPTTKVQKDPSIKPVTPSPSKLVTSPQSEPPAPFPPPRSTSSPYHAGNLLQRHFTNWTKPTSPTRSTEAESVLHSEGSRRAADAKPKRWISFKSFFRRRKTDEEDDKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGESSEKPAIVFMYRCDPAQGQLSVDQSKARTDQAAVMEKGRAENALLQDSEKKRSHSSPSQIPKKILSHMTHEVTEDFSPRDPRTVVGKQDGRGCTSVTTALSLPELEREDGKEDISDPMDPNPCSATYSNLGQSRAAMIPPKQPRQPKGAVDDAIAFGGKTDQEAPNASQPTPPPLPKKMIIRANTEPISKDLQKSMESSLCVMANPTYDIDPNWDASSAGSSISYELKGLDIESYDSLERPLRKERPVPSAANSISSLTTLSIKDRFSNSMESLSSRRGPSCRQGRGIQKPQRQALYRGLENREEVVGKIRSLHTDALKKLAVKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYYTASYAKDPLNNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPDDPEKDEDDMEETEEDAKGETDGKNPKPCSEAASSQKENQGVMSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPSPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGILQCLLWGPREDLFQTFTACPSLVQRNTLLQNWLDIKRTLLMIKFAEKSLDREGGISLEDWLCAQYLAFATTDSLSCIVKILQHR
Protein: Energy-coupling factor transporter ATP-binding protein EcfA2 (ECF transporter A component EcfA2) (EC 3.6.3.-) (Q5M244)
Organism: Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Function: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity). Expression of the complex plus RibU in de-energized E.coli allows riboflavin uptake.
Subcellular location: Cell membrane {ECO:0000305|PubMed:23359690}; Peripheral membrane protein {ECO:0000305|PubMed:23359690}.
Interaction partners:
- Energy-coupling factor transporter transmembrane protein EcfT
- Energy-coupling factor transporter ATP-binding protein EcfA1
- Biotin transporter
- Biotin transporter
- Conserved hypothetical, predicted membrane protein
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- ABC transporter ATP-binding protein
- ABC transporter membrane-spanning protein
- DUF4115 domain-containing protein
- Cobalamin biosynthesis protein, putative transporter
Sequence:
MGISLENVSYTYQSGTPFERRALFDMTVTIKDGSYTAFIGHTGSGKSTIMQLLNGLYLPTSGQVKVDDTIINSQSKNKEIKPIRKKVGLVFQFPESQLFAETVLEDIAFGPQNFGVSKEEAEQRALESLRLVGLSDELRDQNPFDLSGGQMRRVAIAGILAMQPDILVLDEPTAGLDPQGRKELMSLFKQLHLSGITIVLVTHLMDDVADYATAVNVMEKGRLVLSGTPKDVFQKVAFLKEKQLGVPKITEFALQLQEKGYSFESLPITIEEFVEVLVHG
Protein: RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (Q9WUA6)
Organism: Mus musculus (Mouse)
Function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
Interaction partners:
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- PH domain leucine-rich repeat-containing protein phosphatase 2
- PH domain leucine-rich repeat-containing protein phosphatase 1
- Proline-rich AKT1 substrate 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Serine/threonine-protein kinase mTOR
- Forkhead box protein O3
- Forkhead box protein O1
- Phosphatidylinositol 3-kinase regulatory subunit gamma
Sequence:
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDDDGMDGMDNERRPHFPQFSYSASGRE
Protein: PCMTD2 protein (Q6PIM4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGGAVSAGEDNDELIDNLKEAQYIRTELVEQAFRAIDRADYYLEEFKENAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILGPFGVNHGVELHSDVIEYAKQKLDFFIRTSDSFDKFDFCEPSFVTGNCLEISPDCSQYDRVYCGAGVQKEHEEYMKNLLKVGGILVMPLEEKLTKITRTGPSAWETKKILAVSFAPLIQPCHSESGKSRLVQLRSPSFVQGWSVVVLSQLTAASTFQAEAILPSQSPTWLRLQVLATMPN
Protein: Gasdermin-A (Gasdermin-1) (Gasdermin-A1) [Cleaved into: Gasdermin-A, N-terminal (GSDMA-NT); Gasdermin-A, C-terminal (GSDMA-CT)] (Q9EST1)
Organism: Mus musculus (Mouse)
Function: This form constitutes the precursor of the pore-forming protein and acts as a sensor of bacterial infection: upon infection, specifically cleaved by bacterial effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N-terminal) that binds to membranes and forms pores, triggering pyroptosis.
Subcellular location: [Gasdermin-A]: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96QA5}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6}.; SUBCELLULAR LOCATION: [Gasdermin-A, N-terminal]: Cell membrane {ECO:0000250|UniProtKB:Q5Y4Y6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
Interaction partners:
- Gasdermin-E
Sequence:
MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVHTDYTLLDVLEPGSSPSDPTDSGNFSFKNMLDARVEGDVDVPKTVKVKGTAGLSRSSTLEVQTLSVAPTALENLHKERKLSADHPFLKEMRERGENLYVVMEVVETLQEVTLERAGKAEGCFSLPFFAPLGLQGSVNHKEAVTIPKGCVLAYRVRQLMVNGKDEWGIPHICNDSMQTFPPGEKPGEGKFILIQASDVGEMHEDFKTLKEEVQRETQEVEKLSPVGRSSLLTSLSHLLGKKKELQDLEQTLEGALDKGHEVTLEALPKDVLLSKDAMDAILYFLGALTVLSEAQQKLLVKSLEKKILPVQLKLVESTMEKNFLQDKEGVFPLQPDLLSSLGEEELILTEALVGLSGLEVQRSGPQYTWDPDTLPHLCALYAGLSLLQLLSKNS
Protein: Mediator of RNA polymerase II transcription subunit 29 (Mediator complex subunit 29) (Protein intersex) (Q7KBL8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for female somatic sexual development.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 28
- Mediator of RNA polymerase II transcription subunit 18
- Mediator of RNA polymerase II transcription subunit 20
- Mediator of RNA polymerase II transcription subunit 1
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 16
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 19
Sequence:
MNPNMNMMPMSGPQMMQVMQSSPSGPPGPVQHQQQQPPQPLQQQQQAEKLDNISRVKSLLGPLRESMFLTIRSSAFALQQNNLADNLKRDTGAHHVPRFDKHLEDFYACCDQIEIHLKTAMQCLQQQNSSNHYLPGPVTPMRMETFMPDNAGPISYPTYLNTVRVHIQSAKDIHDTLISAAQNISQAD
Protein: Transcription factor protein (F6TNN0)
Organism: Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Interaction partners:
- BZIP domain-containing protein
- [tau protein] kinase
- Kelch-like ECH-associated protein 1
- non-specific serine/threonine protein kinase
- histone acetyltransferase
Sequence:
MQVIRNIPEKKNLAFGLLDIGICLAILQLTNVNNPSDNESYNEDSFIGGPMVGIIPYQPLQQRLHFQDMKVLDDYEYAMSTYRSIIRDVQTRIPTASVSQQQNINNVTAMMLRVGRTSNAVERNSDTEHRNSNVSSFPVLDENRESSGLNYTVPRFDVFNETQQDEMDTNIVDNDVLTQLSQNLDDVRWRCYINDPSVRECLTLPIMPSSSAPLNCNESAEYYEGVQTHLVLSEEFGSNIGIQESEDSASDFNPSPIVSNQNTVMDTYSKNSLEYEPEATMSFDYNSQIDVTYLEDSDMMQLMYQQDVDLGFRWPSRDPVKNLDEIDEVLNMKKTTDVGEFFVDGETGEQIPISKVQNNSKQQELNDKVETSQAVEPSTEPTSSYFSIDEYLEILNESIDDIQPQVVEQTNLNQISEESIIIEDLTDLLTDNENGSTMEQNNAHLWQDMSAIPQLPGKSSEAEGQLGTVNVINTNVSLTNATVESNQTNENTLHQQGTRNINLGYKPVAFENEQPFATQPYNVYKTPAFNPTVPCKPSFSSPSYNTSLNGEDGIPMDGCLSLPIVTSPQGLLHNQINSYQAPMETGDSPPYDEVSPVLSFHGEPGSMFFDEANVNEMLDDIINMNSMNQVYNNSTESAYLNMNPAVFVPPPLQANPPQISFNDTKSLDGSTSDQLKISETCDSDSGVSMSPHSFYMGHQRMERDSIDNETSLHETSFATNALKVINHNHTYDGTVGKPRIIKKKPDKSASHIRESRDERKARELNIPFTLDEIIMSPVEEYNEMLARTPLTTAQQTLIKDIRRRGKNKVAAQNCRKRKIETITTMEEDVDVLRGRKNDLEMEQDELEARKQNLKSQYNALYQQIFRSLRDESGRPYDPSLYTLEQVEGAVLLVPRNLRNRDHNNSDHEDHVDFTRVKMEKRD
Protein: Primary component of eisosomes (Eurofung) (Q5B2L3)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Uncharacterized protein
Sequence:
MHRTYSMRQSRLPTASQIENPPPPLSSTKTNRWMGKGGLGHAFRKNAAGAFGPDLARKLSQLVKMEKNVMRSMELVSRERMETAQQLSIWGENCDEDVSDITDKLGVLLYEVGELEDMYVDRYDQYRVTIKSIRNIEASVQPSRDRKQKITDEIAKLKYKDPNSPRIVVLEQELVRAEAESLVAEAQLSNITREKLKAAFQYQFDALREHCEKVAIIAGYGKHLLDLIDDTPVTPGETRQAYDGYDASKAIIQDCEDALANWVSSKAAVKSSLSQRSRTLSQRRQDNINKGRENGVDLSSQDQPLRGDRDSWVAAEQHPSYHHDDDEEAASDGDIRGREEEREPVPV
Protein: Complement C1s subcomponent (Q5F3N3)
Organism: Gallus gallus (Chicken)
Interaction partners:
Sequence:
MWYLIFFCHPVWANAASMYGEILSPNYPQAYPNDLQESWEIQVPPGYGIRLYFTHLDLEPSQNCEYDSVKILSGGRVERLLCGSKKTHAPGSPIVEEFYMPYNTLTMTFQSDFSNEERFTGFAAYYVAVDLDECTDFVDELCSHYCNNYIGGYFCTCPPDYFLYEDKKTCGVNCSGNVFTEPSGEIASPNYPNQYPENSQCKYQVVLKSGYFVALTIHSDDFDVEPADSTGNCRDSLTLVSGKRRYGPYCGSKFPGPPEIKTRSNILDIIFQTNHMVQRKGWKIRYYAEPITCLPSVTPNSVLDPKKDRYIFTDSVKVTCVEGYEIVRQYDSIRTFHSICQNNGEWSNSDFSCVPVNCGDPSPIDNGNYVYISELHEPLYQATVQYFCKAPYYTLQNKEEAVYQCSASGQWISEEMGTELPTCVAVCGIPSNPIRETGKIFGGTLAAKGNFPWQVFFHSPRGAGVLISERWVMTAAHVLDGYDLPTMYAGTINIGETALRNGKQLVPEASFIHPGWKRLPTNTHRTDFDNDIALLKLKEPVEMGPNISPLCLPGKSPEYELQIGTLGYIAGWGKREKGRLPNYLWKAQIPVVDMDKCRSVKPEGSADSSAYRFTDNMICAGGGKDSCNGDSGGAYSVQDPFNSSQSYVAGLVSWGPRCGTFGLYTKVVRYVDWITETMNKHDTKKPSIIS
Protein: Tln1 protein (Q498D4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASAPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEIKAAAREGKLKPLPGETMEKCTQDLGNSTKAVSSAIAKLLGEIAQGNENYAGIAARDVAGGLRSLAQAARGVAALTTDPAVQAIVLDTASDALDKASSLIEEAKKASGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRQLETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASQAKPAAVAAENEEIGAHIKHRVQELGHGCSALVTKAGALQCSPSDVYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGAETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAFHPEVAPDVRLRALHFGRECANGYLELLDHVLLTLQKPNPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKVRAAPSLSPVTGPRGLHLCPFSLCLPHSPPLCNLLPTGGR
Protein: Replication initiator 1 (C9JZE3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDGRRVPAQPAAEFSLTPGGYRSVGRSRRCSRGSIPRNIPKRSWKKPHPQLCSLQEEEPMLERRCRGPLAMGLAQPRLLSGPSQESPQTLGKESRGLRQQGTSVAQSGAQAPGRAHRCAHCRRHFPGWVALWLHTRRCQARLPLPCPECGRRFRHAPFLALHRQVHAAATPDLGFACHLCGQSFRGWVALVLHLRAHSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICGNCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPRPRGRPAVTAPRPGGDAVDRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNL
Protein: SEC14-like protein 5 (O43304)
Organism: Homo sapiens (Human)
Interaction partners:
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
Sequence:
MVQRYQSPVRVYKYPFELVMAAYEKRFPTCPQIPVFLGSEVLRESRSPDGAVHVVERSCRLRVDAPRLLRKIAGVEHVVFVQTNILNWKERTLLIEAHNETFANRVVVNEHCSYTVHPENEDWTCFEQSASLDIRSFFGFENALEKIAMKQYTANVKRGKEVIEHYLNELISQGTSHIPRWTPAPVREEDARNQAGPRDPSSLEAHGPRSTLGPALEAVSMDGDKLDADYIERCLGHLTPMQESCLIQLRHWLQETHKGKIPKDEHILRFLRAHDFHLDKAREMLRQSLSWRKQHQVDLLLQTWQPPALLEEFYAGGWHYQDIDGRPLYILRLGQMDTKGLMKAVGEEALLRHVLSVNEEGQKRCEGSTRQLGRPISSWTCLLDLEGLNMRHLWRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRRKFLIYSGSNYQGPGGLVDYLDREVIPDFLGGESVCNVPEGGLVPKSLYMTEEEQEHTDQLWQWSETYHSASVLRGAPHEVAVEILEGESVITWDFDILRGDVVFSLYHTKQAPRLGAREPGTRASGQLIDKGWVLGRDYSRVEAPLVCREGESIQGSHVTRWPGVYLLQWQMHSPPSSVACSLPGVDDVLTALHSPGPKCKLLYYCEVLASEDFRGSMSSLESCTSGFSQLSAATSSSSSGQSHSSSLVSR
Protein: DNA-directed RNA polymerase subunit (EC 2.7.7.6) (Q584K3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DNA-directed RNA polymerase subunit beta
- Plastid-encoded RNA polymerase subunit alpha
- RNA polymerase-like protein
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- DNA-direcetd RNA polymerase II, subunit 9, putative
- DNA-directed RNA polymerase II, putative
- DNA-directed RNA polymerase subunit
- Transcription initiation protein, putative
- Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2
Sequence:
MSGGAALPVSQMELQKVNEVQFEIFKERQIKSYAVCLVEHAKSYERGRPVRGGINDLRMGTTDFEFACETCHRKHPECPGHFGYIELAEPVFNIGVFDLVLQVLKCVCKTCGALLLNTREQDVHKKLQHMTGLNRLRQVAKMAEAKCRVSTSTEDDMGIDGFDSAPFNGGSGMGPGATRGCGASQPRVSRFYGIYPTLVIKAVHEEQDAEWHADKVRQVLDRVSDDDARLMGFDPQRCHPRDLVLTVLPVPPPQVRPAISFGGLRSDDELTHQIMSIVKRNNQLRRDKESDVQAAIDRSRALLQEHVATYFNNASTYYKPTKVNDTKKLKSLTERLKGKYGRLRGNLMGKRVDFSARTVITGDPNIDVDEVGVPFSVAMTLTFPERVNTVNKKRLTEFARRTVYPSANYIHHPNGTITKLALLRDRSKVTLNIGDVVERHVINGDVVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSLLGSYRLTDKDTFLDKYFVQSVALWLDLWQLPIPAILKPRPLWTGKQVFSLILPEVNHPATPQDRPPFPHNDSVVMIRRGQLLCGPITKSIVGAAPGSLIHVIFNEHGSDEVARFINGVQRVTTFFLLNFGFSVGVQDTVADSDTLRQMNDVLVKTRRNVEKIGAAANNRTLNRKAGMTLLQSFEADVNSALNKCREEAAKKALSNVRRTNSFKVMIEAGSKGTDLNICQIAVFVGQQNVAGSRIPFGFRRRTLPHFMLDDYGETSRGMANRGYVEGLKPHEFFFHTMAGREGLIDTAVKTSDTGYLQRKLIKALEDVHAAYDGTVRNANDELIQFMYGEDGLDGARIEGGQLFPLPFRDDKEMEDTYKYEYDVDGTFSGKVGGNYMDPHVRKMLRADPQNVRKLQEEYEQLTADREWSRKMLDLEDRDKLKLNLPVNPGRLIQNARSTMGKRSQVSNLSPITIIDHVRKLQEDLMKLFPSYHRGGDGYIRNTLSRERIESALTLFNVHLRQLLASKRVLKEYKLNDRAFEYLLKEIRTKYHQSLTTPGENIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLGVPRLLELLNVSRNQKHASMTVSLFPPYDEKRNAQKAQHLIEYCTLESITRRIQFIYDPDPRHTVVEADRDILELEWNVMDESDAELRIQEVVAGSPWVVRLELDVDMVTDKALDMKDVKQAILRVDESYIIETGMANNVRQRTIRMRSRYNEGADSIPKLKREIPALLARVHLRGIPGVRRALLKDTTEFTVDQATGKMSGNKIWAIDTDGTALRRAFIGVVGEDGKNIINAVKTSSNKVPEVCSLLGIEAARSKMLTELREAYLAYGLNINYRHYTILVDTICQHGYLMAVSRSGINRSDTSGPLMRCSFEETVKVLMAAASFGECDPVRGVSANLVLGNQARVGTGLFDLVLNMAALQQAVPQAEAVAPGKDVNVYHSLGSTLQQNIQSSIAYRPRDHDATPFVNNASLFLRQGFGGGSSSAPVTASAPYNPSTTYHGGRLEASAVHRSQAYSTSPALEYGGREASASQMYSVMSSASAFNPVSTRMSSVAHSYSEYSEASSYHLQHSVAPTSMQASLPRTDNSMTMQGIGSVSVPYTPHAMSSAAPPSQVYASTEVGRSHSEDSRSQSALYVPTLSPTHAGYAIRGDEPSTHRSDSNVMWREAGGGREQDEEDDLSTNYMPTAKTPQQVAPPTAAEFGDEEEEEQ
Protein: Uncharacterized protein (Q388J1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MLTQAGEEEAVAETLTKNLSCLYRAFTLGSDRKEQMCVVQHLMSFLSLPVMGITVGTFLGRYGAVGERGVTANNSSAFALLLLEYFTVEAWNNSVFYLHINNTEKQGEWARAAWALVDILPPTHRVVSALHALRGITGC
Protein: Sperm-specific protein Don juan (O01352)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in the final steps of mitochondrial differentiation within the flagellum.
Subcellular location: Nucleus {ECO:0000269|PubMed:9788872}. Mitochondrion {ECO:0000269|PubMed:9788872}. Note=Predominantly nuclear. Some fraction is associated with mitochondria.
Interaction partners:
- AT13777p
- GEO12122p1
- Male-specific sperm protein Mst84Dd
- MIP06038p
- LP10995p
- Uncharacterized protein, isoform B
- GEO13348p1
- 10 kDa heat shock protein, mitochondrial
- Male-specific sperm protein Mst84Dc
- Cytosol aminopeptidase
Sequence:
MFKRTALILRRCFQPTFIRPHHINVLENFKEADDLPNQGQAKFVDVSIHDPQHIRSALVSPMQRKFLQDLEQQQTVRIKWFKEGNQDELENMKNECRRLALEIIMAAKGGDIKKACKELAEKEKCKQIELKKKCKELEKKTKCAKKDPCKKKDPCKKKDPCKKKDPCKKKDPCKKKDPCKKKDPCKKKDPCKKKGGDLKKKCKKLAEKEKCKKLAKKEKMKKLQKKCKKMAQKEKCKKMAKKDKCKKK
Protein: Zinc finger protein 473 (M0QZY7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAEEFVTLKDVGMDFTLGDWEQLGLEQGDTFWDTALDNCQDLFLLDPPRPNLTSHPDGSEDLEPLAGGSPEATSPDVTETKNSPLMEDFFEEGFSQEIIEML
Protein: E3 ubiquitin-protein ligase PPP1R11 (Protein phosphatase 1 regulatory subunit 11) (Q9VRC5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- GH07711p
- Nuclear inhibitor of protein phosphatase 1
Sequence:
MDSNCDLSMVNGQTEPKDPKWASSSTQITSRASETFSGVGSAISTETSLQPVAAPTMYCLRLAQQRPITERHVHFHAGVIDNEHMNRRKSKCCCIYRKPHPFGESSSSTDDECEHCFGHPEVRTRNRLEKQRIQEQQNGCSCCHHHHRLHSNRNNRPPTEEIAQHKDDLAKEEPKSVVNNESSLKLLNEENVKSSKPEKKNNSNNRLEVTFVELD
Protein: Smooth, isoform AB (A0A0B4KF04)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPYNGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTGEMQSTVVVALDDAAEERAEKWENSTEKRILWMLQPPLLGPGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKLCFSSSKSMNGAWNNAASEGMIEKENEVDTKVDIYN
Protein: RTR1-type domain-containing protein (Q38C26)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Nucleoside diphosphate kinase-like domain-containing protein
Sequence:
MSCGGAWEALIDRAAMEVSKFLSATKDAFHQDSPTAEWMLNLLDDNALRDVVMERNFNALCGMVGCAAMPPAAVGRVEGQLRQEAIGTGKNILNRNDEEDTVSDGEDDGGDAADAFRRYEKYREQICAGREAATALSGVDMTKCFCSPDCAEQFAAMLAKVPRTLVYSREGLVNSVGGLFPNMQFSVLQQLAGAEATVVPDIREKEVVEGQEKKLDLPIPSIGNEENKDHKVKLRELLESIQAVQPVWSRGVQEVRPFDTRKGTMQKMPIPLMVYDWLGTVSTDKTKSIFASVCYSNTRKSDRFPCVGGGRSTNLFVRCMQPVLDACIRKGKELSEGRAADEGCAENPCVDPALQHQRLTLFVRHVFSGETSATLSRLLMYDQATLERAWGAWNSTGLLASLSFPSAVPGDFTCGGGSPARIYLAVVLTAAAALCAPAIWVEWLQEDNGLAEVLEALGCTSDDFIACVRALVVE
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1 (Oligosaccharyl transferase subunit WBP1) (A0A1D8PF22)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU361142}; Single-pass type I membrane protein {ECO:0000256|RuleBase:RU361142}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit delta
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2
- Dolichyl-diphosphooligosaccharide--protein glycotransferase
- Dolichyl-diphosphooligosaccharide--protein glycotransferase
- Protein transport protein SEC61 subunit alpha
- Translocon subunit
- Mannosyl-oligosaccharide glucosidase
- Dol-P-Glc:Glc
Sequence:
MLKQLYFFLVCLLWTTVNASRFDVEHALVLYDPELLPLNDTSSLTPEVAQFIEYLSDKFDVKISDYNSEDINLFFDDYPRYEHLVLFPSSKKTITSKEALSSHNLLRFINENSNIFVVGGSQSVLPDGLRGFLNELGVFPSPKNYKYIDHFNSKNGVVQLNRDNVVEGNRLVQELSVTKYDGNAALISNNELIFPIVRSSATGYTNKVGEPIDADKTWTFGEQGYLAVGFEALNNARLVWVGSNSLLAEPQLYKWCFQQQGKLKLQFVEHIKADEPSKPNPHLYRIKDQAIYTIGVSEFVDGKWIPFEVKDEKDQLQLSFKMLDPYQRLNLKPLGPVSAISNSTELDTYAYFVNFTVPDHHGMFTFELDYKRPGLSYLVDKRVVTVRHFANDEFKRSWDISNSWLYVASAVFVIIAWFVFVVSYIYIGKSNYSKKNV