wanglab/gogpt-training-data huggingface dataset:
Protein: Sperm associated antigen 9 (A0A8I6AXC7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSEQLEATAHSRIRKERPISLGIFPLPAGDGLLTPDTQKGGETPGSEQWKFQELSQPRSHTSLKDELSDISQGGSKATTPASTANSDVSAIPPDTPSKEDNEGLVKGTDTPNKAEISKHIEVQVAQETRNVSTDSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNVVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKSRINDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNAAKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVANGQGENKMKNLPVPVYLRPLDEKDASMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVSALESEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSQVWICTSTHSTTKVIIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEELSDSGQVDRASLCGSMTSNSSAEMDSLLGGITVVGCSTEGVTGAAASPSTNGASPVIEKPPEVEAENSEIDENIPTAEEATEATEGNAGSTEDAVDISQPGVYTEHVFTDPLGVQIPEDLSPVFQSSNDSDVYKDQISVLPNEQDLAREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGLDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTESKKILGIWFSVAANKTSGTPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVVSPQSSSSGADLTADKAGSSAQEPSSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMCGNE
Protein: Angiopoietin-1 receptor (EC 2.7.10.1) (TEK tyrosine kinase, endothelial) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor Tie-2) (O73791)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q02763}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000250|UniProtKB:Q02763}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q02763}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Recruited to cell-cell contacts in quiescent endothelial cells (By similarity). Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell (By similarity). {ECO:0000250|UniProtKB:Q02763}.
Interaction partners:
- Angiopoietin 2a.
- Angiopoietin 4.
- Angiopoietin 2b.
- Angiopoietin 1.
- Platelet-derived growth factor beta polypeptide a
- Vascular endothelial growth factor C
- Vascular endothelial growth factor A-A
- C-fos induced growth factor
- Fibroblast growth factor
- Epidermal growth factor.
Sequence:
MCLLDSCTALLLLGCWMSGSAVRISDVTLVNPDPVVSPLTAPSLLCVSSDWSSGGSVLALGQEFPRPQGSVLALGQEFPHTEPRPHPAAATVTWSSRSHAFGAFYCQIRNSTGRKIYTYKMLQEAAFLPESLTITVNQGENINISYSRRLYSPEDTVIHKNGHFEHSSPKEDISDIIHYPVTNAKAESHAGIYAIRYISAAPSSAAITRLIVRSCRAGFWGPNCTESCPRCANGGVCDDTTGECVCPPGFRGHTCDIVCGEGRFGAGCKERCVDGVCRALVFCLRDPYGCSCASGWRGLSCNDACPDGYYGAGCTQKCVCAKGRCDRFRGCVCAGRHGSRCEEADSSPVISHLRDVEINTGVELSVNCSASGRPAPLHGDITLITANRTTIAAVDTHTLNDQSTSVFRVQQVRVSSAGRWRCQVNNTHMQVEDEFTVEVKVPPRPQNPPVLQGSGPRHLLLLLNTEPYSGDGPIATTTLLYRPASAHTWSSVTAHGPLVRLDNLYPMTQYLTQVQLSRPGPGGAGQAGPAATFSTQVLELPVGVKLSAVSQTALLLSWDIAPAEQHCTYEVSCLQAGAPGTLRTFQLPSNSSAMHLSDLKPRHKYQCTVRSSCGVGQNHPSASAWTLSDQLPPPPANISIWNISDTSAVLTWAVAEGESVSRAVIRFQQVEQAQYRQQVELPVQTQQLHMRFQLLGLRPNTGYQLQLWTVNNMGESAESPPVSLMTLPQQESSALFAAHGHLLLYAILGSAGMTCCTVLLAFCIVLQLKRNTLQRRIHSILREEPAVHFSSAPPPHRRSAVVSRSLVFPALQWSDIQFQDVLGEGNFGQVLKARIRKDGLRMDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNIIHLLGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRTASTLSSQQLLAFSADVARGMSYLSQKQFIHRDLAARNVLVGENFVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEVVSLGGTPYCGMTCAELYEKLPLGFRLEKPLNCDDEVYELMQQCWREKPFERPSFSQILLSLGRMLEERKTYVNTTLYEKFTYAGIDCSAEEAG
Protein: Pancreas/duodenum homeobox protein 1 (Q72BE4)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Interaction partners:
Sequence:
MKTTDCARLFSSTVLADLFPAERADAFFEALYGDAEDGAYDIRLVFVTQEKNRLTFAFELHQRPGKCLACNLTYGLPPVFARHPVIGIGRLAGDIASILGISADAIEWTLGQTQEHSRSLHSVPLHFVVKG
Protein: RhoGAP1A (Q6W437)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
XEXNTIFFKIDELYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLXTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSVRDQLAMEVANSGSGGFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLK
Protein: DNA-directed RNA polymerase subunit Rpo1N (EC 2.7.7.6) (DNA-directed RNA polymerase subunit A') (Q980R2)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00863}.
Interaction partners:
- DNA-directed RNA polymerase subunit Rpo11
- DNA-directed RNA polymerase subunit Rpo1C
- DNA-directed RNA polymerase subunit Rpo3
- DNA-directed RNA polymerase subunit Rpo5
- DNA-directed RNA polymerase subunit Rpo2
- DNA-directed RNA polymerase, subunit B''
- DNA-directed RNA polymerase subunit Rpo6
- DNA-directed RNA polymerase subunit Rpo10
- DNA-directed RNA polymerase subunit Rpo7
- DNA-directed RNA polymerase subunit Rpo12
Sequence:
MSEKNIKGIKFGILSPDEIRKMSVTAIITPDVYDEDGTPIEGSVMDPRLGVIEPGQKCPTCGNTLGNCPGHFGHIELVRPVIHVGLVKHIYEFLKATCRRCGRVKISEDEIEKYSRIYNAIKKRWPSAARRLTEYVKKTAMKAQVCPHCNEKQYKIKLEKPYNFYEERKEGVAKLTPSDIRERLEKIPDSDVEILGYDPTTSRPEWMILTVLPVPPITIRPSIMIESGIRAEDDLTHKLVDIVRINERLKESIDAGAPQLIIEDLWDLLQYHVATYFDNEIPGLPPSKHRSGRPLRTLAQRLKGKEGRFRGNLSGKRVDFSSRTVISPDPNISIDEVGVPEIIAKTLTVPERITPWNIEKLRQFVINGPDKWPGANYVIRPDGRRIDLRYVKDRKELASTLAPGYIIERHLIDGDIVLFNRQPSLHRISMMAHRVRVLKGLTFRLNLLVCPPYNADFDGDEMNLHVPQSEEAIAEAKEIMLVHKNIITPRYGGPIIGAAQDYISGAYLLTVKTTLLTKEEAQQILGVADVKIDLGEPAILAPREYYTGKQVISAFLPKDFNFHGQANVSSGPRLCKNEDCPHDSYVVIKNGILLEGVFDKKAIGNQQPESILHWLIKEYSDEYGKWLMDNLFRVFIRFVELQGFTMRLEDVSLGDDVKKEIYNEIDRAKVEVDNLIQKYKNGELEPIPGRTLEESLENYILDTLDKLRSTAGDIASKYLDPFNFAYVMARTGARGSVLNITQMAAMLGQQSVRGERIKRGYMTRTLPHFKPYDISPEARGFIYSSFRTGLKPTELFFHAAGGREGLVDTAVRTSQSGYMQRRLINALSDLRAEYDGTVRSLYGEVVQVAYGDDGVFPMYSAHGKTVDVNRIFERVVGWKA
Protein: Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (SET domain-containing protein 7) (Q6DHG0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Has also methyltransferase activity toward non-histone proteins.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8WTS6}. Chromosome {ECO:0000250|UniProtKB:Q8WTS6}.
Interaction partners:
- Forkhead box O3b.
- Forkhead box protein O1-B
- Forkhead box O4
- Forkhead box O3A
- Forkhead box protein O1-A
- Forkhead box O6 a
- Polycomb protein eed
- Cellular tumor antigen p53
- Histone H3
- Histone H3.2
Sequence:
MDSDDDNMEEVVEGPLDEDDQPHGFCTVTYSSSDRFEGHFVHGEKNGKGKFFFFDGSTLEGFYVDDALQGQGVYTYEDGGALHGFYVDGELNGPAQEFNSDGQLVFRGRYKDNIRYGMCWVYYPDGACVVGEVNEEGEMTGKAVAYVYPDGRTALYGSFVDGELIEARLATLTTQENGRPHFTVDPDSPIYCYDKSTSSCIAGHKLLPDPYESQRVYVGQSLISGAGEGLFAQTEAEANTVMAFYNGVRITHTEVDSRDWSMNGNTISLDEDTVIDVPAPFNMTENYCGSLGHKANHSFSPNCKYDQYVHPRFGQIKCIRTIRAVEKDEELTVAYGYDHEPSGKSGPEAPEWYTKQFLEFQQRESGKGADETC
Protein: Protein BANP (A0A0S2Z5G4)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MMSEHDLADVVQIAVEDLSPDHPVVLENHVVTDEDEPALKRQRLEINCQDPSIKSFLYSINQTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCAVPGRRQNTIVVKVPGQEDSHHEDGESGSEASDSVSSCGQAGSQSIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPNSSSYCPSEPMMSTPPPASELPQPQPQPQALHYALANAQQVQIHQIGEDGQVQVGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQLLEATRIPCLLAPSVFKASSGQVLQGAQLIAVASSDPAAAGVDGSPLQGSDIQVQYVQLAPVSDHTAGAQTAEALQPTLQPEMQLEHGAIQIQ
Protein: Membrane-bound lytic murein transglycosylase A (EC 4.2.2.n1) (Mlt38) (Murein hydrolase A) (P0A935)
Organism: Escherichia coli (strain K12)
Function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi.
Subcellular location: Cell outer membrane; Lipid-anchor.
Interaction partners:
- Membrane-bound lytic murein transglycosylase D
- Soluble lytic murein transglycosylase
- Endo-type membrane-bound lytic murein transglycosylase A
- Membrane-bound lytic murein transglycosylase B
- Membrane-bound lytic murein transglycosylase C
- Membrane-bound lytic murein transglycosylase F
- Penicillin-binding protein 1B
- Endolytic murein transglycosylase
- Endolytic peptidoglycan transglycosylase RlpA
- Anhydromuropeptide permease
Sequence:
MKGRWVKYLLMGTVVAMLAACSSKPTDRGQQYKDGKFTQPFSLVNQPDAVGAPINAGDFAEQINHIRNSSPRLYGNQSNVYNAVQEWLRAGGDTRNMRQFGIDAWQMEGADNYGNVQFTGYYTPVIQARHTRQGEFQYPIYRMPPKRGRLPSRAEIYAGALSDKYILAYSNSLMDNFIMDVQGSGYIDFGDGSPLNFFSYAGKNGHAYRSIGKVLIDRGEVKKEDMSMQAIRHWGETHSEAEVRELLEQNPSFVFFKPQSFAPVKGASAVPLVGRASVASDRSIIPPGTTLLAEVPLLDNNGKFNGQYELRLMVALDVGGAIKGQHFDIYQGIGPEAGHRAGWYNHYGRVWVLKTAPGAGNVFSG
Protein: ERCC excision repair 1, endonuclease non-catalytic subunit (K7ER89)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDPGKDKEGVPQPSGPPARKKFVIPLDEDEVPPGVAKPLFRSTQSLPTVDTSAQAAPQTYAEYAISQPLEGAGATCPTGSEPLAGETPNQALKPGAKSNSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILADCTLILAWSPEEAGRYLETYKAYEQKPADLLMEKLEQDFVSR
Protein: Ubiquitin-conjugating enzyme E2 (Q84K93)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
MASKRILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPSDSPYAGGVFLVSIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILKEQWSPALTISKVLLSICSLLTDPNPDDPLVLEIAHMYKTDRAKYEATARGWTQKYAMG
Protein: LOB domain-containing protein 38 (ASYMMETRIC LEAVES 2-like protein 40) (AS2-like protein 40) (Q9SN23)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein NLP7
- At1g71030/F23N20_2
- MADS-box transcription factor ANR1
- Transcription factor TGA4
- LOB domain-containing protein 26
- Transcription factor TGA1
- LOB domain-containing protein 35
- LOB domain-containing protein 8
- LOB domain-containing protein 28
- Ethylene-responsive transcription factor ERF060
Sequence:
MSCNGCRVLRKGCSENCILRPCIQWIESPEAQGHATVFVAKFFGRAGLMSFISAVPESQCPALFQSLLYEACGRTVNPVNGAVGLLWTGNWNVCQAAVETVLRGGSLKPIPELLNGGGFAGFPSPTSDEASEICTEMLNLRKADDSGDRNIYHHCRFSSSRSRSRSTASPPKRKRLSSEQQPSSELDLSLIPIYPIKTLPFKEDTPSMYSEESVTTVSFQNNNAGDRYVRCGGGGGGATTKLLNLFA
Protein: Caspase 4, apoptosis-related cysteine peptidase (Q3MHS1)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MAENNHPDKPLKVLEELGKEFLTEYLEKLVQSNVLKLKEEEKQKFNNAERSDKRWVFVDVLKRKHNQVGKMLLQTFLNVDSGSHHGEANLEMEEPEESVDTLKLCSSEEFTRLCREKKQEIYPIKETNGRTRKALIICNTEFKHLSLRYGANIDISGMKGLLEELGYDVVVKEELTAEGMESEMKDFAALSEHQTSDSTFLVLMSHGTLQGLCGTMHSEATPDVLLYDTIYQIFNNCHCPGLRDKPKVIIVQACRGGNPGEVWIRESSGAHSYRAVDLPRNMEADAVRMSHVEKDFIALYSTTPHHLSYRDKTRGSYFISKLISCFRIHACSCHLFDIFLKVQQSFEKASINSQMPTIDRATLTRYFYLFPGN
Protein: Tudor domain-containing 6-like (tdrd6-like) (Xenopus tudor repeat) (Q90WE3)
Organism: Xenopus laevis (African clawed frog)
Function: Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity). Component of cytoplasmic mRNP particle through interaction with FRGY2, and binds to maternal mRNA related to cell cycle (RCC1, RHAMM, INCENP-A, MAD2L1, HELLS) and a germ plasm specific mRNA (Dead end/Dnd1), it is proposed a role in translational activation of the maternal mRNAs repressed in mRNP particle.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21314676}. Note=Localizes in the germ plasm, most precisely in the cytoplasmic mRNP particle (messenger ribonucleoprotein, which corresponds to mRNA with bound proteins). {ECO:0000269|PubMed:21314676}.
Interaction partners:
Sequence:
MVEVYFIDHGNTEMVDWYNVKKLPAELREMPGLAIHCCVADICPLGVRWSPEAILAFKIAVVDKKLIIYVVSKELHKYIIEVLDNSRIEQRSMAKILSAAGHAKYEEVEPVAQHTGNMSDIDNETQQQFLGYINKDTSSLKTQQKEDVCSMEDDNSVPYSPYEDQFFEPGATIEVVVSCIISPGLFWCQNASLSSKLEKLMAKIQDYCSSTDCPYERGAYACLAKSSCDGKWYRAFITNNRPGSKANANQVEVLYVDYGITETVLVKDLRCIESELFDLKAQAFRCSLYNLIAPDSENPFEWDTKATLSFHRFVDSSAKKCSEFKCTFFATALVKTELSYIVDVFTPFASICKLLVELGHAKQLSHTTLAPSVQLQTYYYSMHDIKIGGEEEVYITYVNSSLEFYCQLSRNTETIDMIASATARVCSEVRKFELSVTPGPLCLAKFSDQQWYRCFINTNKNSTDAFFVDYGNTEKVNKEEMLPIPSDAYELLHFPMQAIKCSLSDMPDTVPSDVVLWFENHVLEKPLRAIIVAKETDGKLIVELYDGSQQINSILKTKLGWKSSRAEGSFGNSEKRNQLNDLDRGGRKETTSKFQPYSQGSKFSPDLDGHSQNGLTYQKPEFQTKEREQFEQKPNLRTPRSYNNDREVYQVQKNMSQSGFAPQKTGGFRSKDREAFEQRPNLKASGLYSQGRETPSMSQNSSYSGFPPQKTGAFRSKERQVSEHKQNSNPPKFYNQERKLSPQLRKASQNGSSSQTEAFWSSGSDQSSEHKPDNASQQRRSTFQESKLTPPLSKLSDLPKQNIALGMKSSVYVAHTNTISDFYVHIAQNTDLSNISEILNNEKGPSDQLDEKYVNLGDLICAFYEDGLYYRAVITEKCADGLLAQYIDYGNTSVIPPTKIYKLPPSLLSIPAMSICCALDKCTTSACEQNMDDLMLKFSERTGDLELSCEFVQYNNRKWNVILCDDQGCINDLFISVSGDPMLNPPLPKEPSVTSETLISASLFVWNLPELGETVEAFASAVDSPEHFWCQLATANVDSLAVKVQEAGEHSIHDGRFSAEIEVGSPCNVIYSDDNYWYRAAVTKMKDDKVTVRFVDYGNEETLQMEQVRRLPADIAAIPVQAFPCSLANFNLSEGCWSSEANTFFYDKVTEGLLEITVLHIQELGLCKIPQASVNVKYNGEDINCEMRRFWQDSFVNTNPFTESLNAKEETAIEDNVIPSQADEDDHSEPSEEPCASESIETPAVDGEVLTANDETKLEALPVSSAEEAAEITDNTDVELMRTEYLLHEVQKSSDLSCLELTLDEDVPDEKNSGTPAVTPLAAEDLCIDYDESNIKKSYSGVTTEMDNRELHQDEDLDLWTSAAQDQEIASSEILGDVPIDKECNYSVEEATDQSCTNIGLEEGPEPVENAFTENINDETDIANVQSKGEEEEAYLVPEESTVAECEIEDFEPEVDLQSKENEGLPDIPLLEGDGDDSVSPEEVSSHEMNEAEGLEDQDQELLGYTGTERAMDDYEVLQSEEQAEDLVPEEDPGTETEHRSYLFEAEEADLPSQEHKDFPEQEEDRVAEHKNDISEPDLQSKEQKEDLVPEEDPGTETEHRSYLFEAEETDLPSQEHKDTVTYTDIPLLEGGVDDFGSKETVSIDYNYEYVTEDVEDLDTENQESQICISGSDNRSKESGPVDLQDFEDEVLFQYTEPTADSASDVRQGDECEFAAHSDENIESPEHPVHTDSTADVCETDVCEPEVADHCHLQDKVVSERTECPVPDDRTKDDHQNNECQCAVDPVENIECQTPVCLVAADRSYTEYTWTVSETESGNMKNIEFQESPAEGDSVGSHGVGATEWKDGEPESLVNPDTPLLEGPVSVDIMHSSDNFEPETDDMEQMEQDQGRMKIESSYVPAPSV
Protein: Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) (P36975)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity).
Subcellular location: Synapse, synaptosome {ECO:0000250}. Note=Complexed with macromolecular elements of the nerve terminal. {ECO:0000250}.
Interaction partners:
- Synaptobrevin
- Syntaxin-1A
- Neuronal synaptobrevin, isoform J
- Synaptotagmin 1
- Alpha-soluble NSF attachment protein
- Vesicle-associated membrane protein 7
- Syntaxin-4
- LD03592p
- Complexin
- Secretory 22, isoform B
Sequence:
MPADPSEEVAPQVPKTELEELQINAQGVADESLESTRRMLALCEESKEAGIRTLVALDDQGEQLDRIEEGMDQINADMREAEKNLSGMEKCCGICVLPCNKSQSFKEDDGTWKGNDDGKVVNNQPQRVMDDRNGMMAQAGYIGRITNDAREDEMEENMGQVNTMIGNLRNMALDMGSELENQNRQIDRINRKGESNEARIAVANQRAHQLLK
Protein: Rifin (O96116)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKLNYTKILLFFFPLNILANNNKNKPSITQRHTPRYTSRVLSECDIRSSIYDNDAEMKSVKETFDRQTSQRFEEYEERMKGKRQKRKEQRDKNIQEIIEKDRMDKSLAEKVEKVCLRCGFGLGGVAAGVGIFGAIAVNEWTKAALVAAAQKGIDAGIKSALKGLEKIYELSDFSYLKWSAMVTPTTYDQPMDLIAIVTKAYNMCDDVEAAKGSLFCQAMEGIANEPDGCPVKTFSQMAVDAAEAAGKVSKTTEEAGIALANNTSYNSYIAIAYSVTAILIIVLIMLIIYLILRYRRKKKMNKKLQYTKLLNQ
Protein: Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) (Q17QQ3)
Organism: Bos taurus (Bovine)
Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P60879}. Cell membrane {ECO:0000250|UniProtKB:P60881}; Lipid-anchor {ECO:0000250|UniProtKB:P60879}. Synapse, synaptosome {ECO:0000250|UniProtKB:P60879}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P60879}. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. Colocalizes with KCNB1 at the cell membrane (By similarity). Colocalizes with PLCL1 at the cell membrane (By similarity). {ECO:0000250|UniProtKB:P60879, ECO:0000250|UniProtKB:P60881}.
Interaction partners:
- Syntaxin-1A
- Syntaxin-1B
- Vesicle-associated membrane protein 2
- Synaptotagmin-1
- Vesicle-associated membrane protein 1
- Alpha-soluble NSF attachment protein
- Syntaxin-3
- Syntaxin-binding protein 1
- Syntaxin 2
- Vesicle-associated membrane protein 7
Sequence:
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
Protein: Doublesex and mab-3 related transcription factor 1 (Q925A6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00070}.
Interaction partners:
- Muellerian-inhibiting factor
- Forkhead box protein L2
- Aromatase
- Nuclear receptor subfamily 0 group B member 1
- Stimulated by retinoic acid 8
- Deleted in azoospermia-like.
- Transcription factor SOX-9
Sequence:
MPNDDAFGKPSAPTEVPHAPGAPPQGKAGGYSKATGAMAGAAGGSSAGGSGGASGSGPSGLGSGSKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCSLIAERQRVMAAQVALRRQQAQEEELGISHPIPLPSAAELLVKRENSASNPCLMAESSSSAQPPPASTPTPTVSEGRMVIQDIPAVTSRGHMENAPDLMSDPAYYSSFYQPSLFPYYNNLYNYPQYSMALSAESSSGDVGNPLGGSPVKNSLRSLPAPYVPAQTGNQWQMKTSEGRHPVSSQYRMHSYYGPPSYLGQSMSQIFTFEEGPSYSEAKASVFSPPSSQDSGLVSLSSSSPMSNESTKGVLECESASSEPSSYAVNQVLEEDEDE
Protein: Short transient receptor potential channel 4 (Trp4) (TrpC4) (Capacitative calcium entry channel 1) (CCE1) (O35119)
Organism: Rattus norvegicus (Rat)
Function: Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.
Subcellular location: [Isoform Alpha]: Cell membrane {ECO:0000269|PubMed:11713258}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform Beta]: Cell membrane {ECO:0000269|PubMed:11713258}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Short transient receptor potential channel 1
- Short transient receptor potential channel 3
- Transient receptor potential cation channel, subfamily C, member 5
- Stromal interaction molecule 1
- Na
- Transient receptor potential cation channel subfamily V member 4
- Transient receptor potential cation channel subfamily A member 1
- Transient receptor potential cation channel subfamily V member 2
- Polycystin-2
- Calcium release-activated calcium channel protein 1
Sequence:
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTDFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQSANAASSASSADSDEKSHSEGNGKDKRKNLSLFDLTTLIHPRSAVIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIQLESKGLASRGDRSIPGLNEQCVLVDHRERNTDTLGLQVGKRVCSSFKSEKVVVEDTVPIIPKEKHAQEEDSSIDYDLSPTDTVAHEDYVTTRL
Protein: Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (P45645)
Organism: Meleagris gallopavo (Wild turkey)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P29992}; Lipid-anchor {ECO:0000250|UniProtKB:P29992}. Cytoplasm {ECO:0000250|UniProtKB:P29992}.
Interaction partners:
- Uncharacterized protein.
- Protein kinase domain-containing protein
Sequence:
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSEEDKKGFTKLVYQNIFTAMQSMIRAMETLKILYKYEQNKANAVLIREVDVEKVMTFEQPYVSAIKTLWNDPGIQECYDRRREYQLSDSAKYYLSDVDRIATPGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
Protein: Mitogen-activated protein kinase sty1 (MAP kinase sty1) (EC 2.7.11.24) (MAP kinase spc1) (Q09892)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that affect cell physiology. Phosphorylates atf1 and mkp1. In conjunction with hal4, has a role in the cellular resistance to toxic cations such as Na(+), Li(+) and Ca(2+). Involved in resistance to arsenite, methylglyoxal and hydrogen peroxide. Involved in induction of thermotolerance in mRNA export, as well as in vacuolar fission.
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation.
Interaction partners:
- Transcription factor atf1
- Protein kinase wis1
- Protein phosphatase 2C homolog 1
- Transcription factor pcr1
- Tyrosine-protein phosphatase 1
- Tyrosine-protein phosphatase 2
- Response regulator mcs4
- Serine/threonine-protein kinase srk1
- Calcium/calmodulin-dependent protein kinase type II
- Transcription factor atf21
Sequence:
MAEFIRTQIFGTCFEITTRYSDLQPIGMGAFGLVCSAKDQLTGMNVAVKKIMKPFSTPVLAKRTYRELKLLKHLRHENIISLSDIFISPFEDIYFVTELLGTDLHRLLTSRPLETQFIQYFLYQILRGLKFVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAEMIEGKPLFPGRDHVNQFSIITELLGTPPMEVIETICSKNTLRFVQSLPQKEKVPFAEKFKNADPDAIDLLEKMLVFDPRKRISAADALAHNYLAPYHDPTDEPVADEVFDWSFQDNDLPVETWKVMMYSEVLSFHNMDNELQS