wanglab/gogpt-training-data huggingface dataset:
Protein: Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural protein UL26) [Cleaved into: Assemblin (EC 3.4.21.97) (Protease) (Pr); Assembly protein (AP) (Capsid assembly protein)] (P10210)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: Acts as a scaffold protein by binding major capsid protein in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein. Cleavages products are evicted from the capsid before or during DNA packaging.
Subcellular location: [Capsid scaffolding protein]: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04008}.; SUBCELLULAR LOCATION: [Assemblin]: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04008}.; SUBCELLULAR LOCATION: [Assembly protein]: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04008}.
Interaction partners:
Sequence:
MAADAPGDRMEEPLPDRAVPIYVAGFLALYDSGDSGELALDPDTVRAALPPDNPLPINVDHRAGCEVGRVLAVVDDPRGPFFVGLIACVQLERVLETAASAAIFERRGPPLSREERLLYLITNYLPSVSLATKRLGGEAHPDRTLFAHVALCAIGRRLGTIVTYDTGLDAAIAPFRHLSPASREGARRLAAEAELALSGRTWAPGVEALTHTLLSTAVNNMMLRDRWSLVAERRRQAGIAGHTYLQASEKFKMWGAEPVSAPARGYKNGAPESTDIPPGSIAAAPQGDRCPIVRQRGVALSPVLPPMNPVPTSGTPAPAPPGDGSYLWIPASHYNQLVAGHAAPQPQPHSAFGFPAAAGSVAYGPHGAGLSQHYPPHVAHQYPGVLFSGPSPLEAQIAALVGAIAADRQAGGQPAAGDPGVRGSGKRRRYEAGPSESYCDQDEPDADYPYYPGEARGAPRGVDSRRAARHSPGTNETITALMGAVTSLQQELAHMRARTSAPYGMYTPVAHYRPQVGEPEPTTTHPALCPPEAVYRPPPHSAPYGPPQGPASHAPTPPYAPAACPPGPPPPPCPSTQTRAPLPTEPAFPPAATGSQPEASNAEAGALVNASSAAHVDVDTARAADLFVSQMMGAR
Protein: Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Telomeric repeat-binding subunit 2) (A0A0U8TRG9)
Organism: Tetrahymena thermophila (strain SB210)
Function: Component of the heterotrimeric replication protein A (RPA) and holoenzyme telomerase ribonucleoprotein complexes. As part of the RPA complex, binds and stabilizes single-stranded DNA (ssDNA) intermediates, that form during DNA replication or upon DNA stress (By similarity). It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (By similarity). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (By similarity). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation (By similarity). Also part of a subcomplex of the holoenzyme telomerase ribonucleoprotein complex: this subcomplex that contains TEB1, RPA2/TEB2, RPA3/TEB3, but not RPA1, mediates the recruitment of telomerase to telomeric DNA via specific interaction between TEB1 and telomeric ssDNA. In the holoenzyme telomerase ribonucleoprotein complex, RPA2/TEB2 and RPA3/TEB3 act as assembly factors for TEB1 incorporation into telomerase holoenzyme. In the holoenzyme telomerase ribonucleoprotein complex, RPA2/TEB2 does not contribute to ssDNA affinity, while it contributes to ssDNA affinity in the RPA complex.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P15927}. Chromosome, telomere {ECO:0000305}.
Interaction partners:
Sequence:
MSNRVQGGFDNNSGNNQSAQKQQAEKIPQITVPLNCFMINQIVKAAKENPQAHSGNHYEWYGAFENAIITAKFEFLQSINDSPKIMGKLSDSTGCIEVVIQKSKMSDELPEFVQAYEIELQNNGNRHKYVRAMLKMRKNAQIQLLYFSIVNDANEISRHGLDLCLRYLQRKHGIEDFMHMTNDKAHNNHNASAQKVHYQIDRNQQPKEQVLELMRQILKHNPNDQIPKSKIIEFFQSQLNQVQINQILQQLVSANEIFSVGSDNYLLNV
Protein: Golgin subfamily A member 2 (I3LSP4)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MWPPLPPPRPGMSEETRQSKLAAAKKKLREYQQKHSPGVPAGAKKKRKIKNGSSPETTTSGDCPTPEDAPKDSADLVTSSADDTVSPGGVLSPCASPLRGTSMATTQNHDAENGPVPIDENTSFSSTESLRQLSQQLNGLVSESSPYINGEGLASPANIKKLESRYHELSLALDSSNLTNKQLSSKIEELKQENQETLDQLEKEKKEFEQKLAKEQGALREQLQVHIQTIGILVSEKTELQTALAHTQQAARQKAGESENLASRLQSSRQRVGELERTLSAVSTQQKQADRYNKELTKERDTLKLELYKNNKSNEDLKQQKSELEEKLRLMATEKAAMQLGMEELQKKLEMSELLLQQFSTQPTPDSSQQLQQALEERAQLETCVGQLQDSLRQLQAERDQYVANLKEDSTVWQHKMQQMNEQLNKLRAEKEHSMSQVQELETSLAELRNQAAPPSGPSETEQRLQAEAEQLQKEVESLARQLQAQVKDNENLSLLNQEQEQRLMELERAAECWGEQAEERKQMLESMQSDRTTISRALTQNRKLKEQLAELQNGFVRLSNENMEITSALHSEQHVKKELAKKLGQLQENLGELKETVEVKSQEAQDLQQQRDQYLGHLQQYVAAYQQLAAEKELLHKQMVLQTQLVDQLQHEDMQGRMAVETARQELQEAQGRLEAANQHNQQLQAQLTLMAVPGEGTELDIEDEDKAGEAPRPKLSVPEELDSREAVVEFFNSALASAEEEQARLRRELKEQKLRCQRLAHLVAPAQDGVEKEAPAPGTEGDSVSAPGTGGDSVPVETHQALQVAMDKLQGRFTELMQEKVDLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKERHREKEEYISRLAQDKEEMKVKLLELQELVLHLVGERNEWQGKFLAAQNPAGEPTVAPPAPQELGAAENQGGLLEVSLSDNVEPTQGEALLGQTLTENPTAQQIMQLLREIQNPQERLGLGSNPCIPFFYRADDNDEVKIMVV
Protein: RE56367p (Q8SWT7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPQTSPNWRQADNERTKGAVSVIAARNWATGTATQDWSQKSSSSWSSTSRRTGISRTRTRPATLTTEMTVAGRAERAGVGAPWCRRFFHTSPLASWLRISFVLLVLPALGFGIQVVTCSNPELGASAPDPVDLTWGGKNTEGQLTTATRSTLPDSPMTTQNDLITTASNLATAKKPATAASEAVVDTAETAETAPPTEATSSWSSTAVARGMSSADGAGEAIATSQSAQIGLTTQATVRQTEAQTASTATQAAAATSAATSAAIASAAAATETAAEMLISTIYPASTETDLHNSIERVEGQRGKMANAFHPGVPDSLTKGFSIPTFLPPFPVFAAADLPAYRAAADAAEAAKLAAEAAAQAAAAKTSSEAVTMSPEEQRRQMFNEQHSYLAAHRDGGDGAGSAVRRNLTMPVLNITAQMGNHAYMPCQIHRLSDKPVSWVRMRDNHIISVDETTFIADERFQSIYQEDHDYTWSLQIKYVEPSDAGWYECQMATEPKLSAKVHLQIVKPKTELIGDQSRFVKAGSKVALHCIVRGTLDPPKYIIWFRGQKKISDSDERTGWYTQLDRNIFGTVGDNQNTIGSLIIPLVRKEDSGNYTCQPSNSVSVSVDLHVLSVNIPHRPSCQRRQGRRKAGGARATRRWDSWESLDSYGRCRERCTHRRPRRDSPIERTPGRGVRLPIICKLLRHLQLRNLG
Protein: Vacuolar protein-sorting-associated protein 36 (ESCRT-II complex subunit VPS36) (Q387W7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU367095}. Endosome {ECO:0000256|RuleBase:RU367095}.
Interaction partners:
- ESCRT-II complex subunit VPS22
- Dolicholphosphate-mannose synthase
- Vacuolar protein sorting-associated protein 28 homolog
- Charged multivesicular body protein 6
- SB domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Class-E vacuolar protein-sorting protein 24
- Polyubiquitin, putative
- Ubiquitin-ribosomal protein eL40 fusion protein
Sequence:
MSSWESCEDGNLVRTGEIVLFVQNETRYHEGDGNLNYDEGKLTLSTDNIFFQPKGAGPIFLRIPLGNIDSPSGGPTVVAQSDGRSPKLHIPLTESGQKAVFSFKVGNIKEFCETLRDVLQQKLLLLRHSEMLTEPLPSITGVVQGSSKATRDDSSAAPANETLLAFTDKAGIAGLMRASAEKTAQGETLRDIDDVMRNASSLVASIRNLQQKQQNIAGTTKAEDNMTIESIEATLGLGATVRASGAGWGLVSAHAGFHKELAWEIHSWITHEKNHHVFGSMPLIPLIELFSLYNKARGECDLVSTNDVLHACRALDQQEYAQYTLKRLSSGRYALQRKDPSIVLKKLEHILGPRLCNEKESGKFTTSADSSPIHNGRDGGVTQPVTQTAVFPESSSMLKGVNEVTFASVLHVTCSVSMDLLEELELQGYLCRSGGEFGCFTFHWNIFVF
Protein: StAR-related lipid transfer protein 7, mitochondrial (START domain-containing protein 7) (StARD7) (Q8R1R3)
Organism: Mus musculus (Mouse)
Function: May play a protective role in mucosal tissues by preventing exaggerated allergic responses.
Subcellular location: Mitochondrion {ECO:0000305}.
Interaction partners:
- Ceramide transfer protein
- Steroidogenic acute regulatory protein, mitochondrial
- StAR-related lipid transfer protein 3
- StAR-related lipid transfer protein 5
Sequence:
MFPRRPPATLAAWLAGARGGGLLSALANQCRFVTGLRVRRAQQIAQLYGRLYSESSRCALLGRFWRRLRGRPGHASVLMAALSGVFVWDEERIQEEELQRSINEMKRLEEMSNIFQSSGVENYPPEPKSPAGGNEKSKDKEEPWEMVMDKKHFKLWRRPITGTHLYQYRVFGTYTDVTPRQFFNVQLDTEYRKKWDALVIKLEVIERDAVSGSEVLHWVTHFPYPMYSRDYVYVRRYSVDQENNVMVLVSRAVEHPSVPESPEFVRVRSYESQMVIRPHKSFDENGFDYLLTYSDNPQTVFPRYCVSWMVSSGMPDFLEKLHMATLKAKNMEIKVKDYISAKPLEMSSEAKATAPSPERKNEGSCGPARIEYA
Protein: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane phosphoprotein Cbp) (Q3U1F9)
Organism: Mus musculus (Mouse)
Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11777944, ECO:0000269|PubMed:12612075, ECO:0000269|PubMed:14645715, ECO:0000269|PubMed:16166631}; Single-pass type III membrane protein {ECO:0000269|PubMed:11777944, ECO:0000269|PubMed:12612075, ECO:0000269|PubMed:14645715, ECO:0000269|PubMed:16166631}. Note=Present in lipid rafts.
Interaction partners:
- Tyrosine-protein kinase CSK
- Proto-oncogene tyrosine-protein kinase LCK
- Tyrosine-protein kinase Lyn
- Tyrosine-protein kinase Fyn
- Proto-oncogene tyrosine-protein kinase Src
- Growth factor receptor-bound protein 2
- Na
Sequence:
MGPAGSVLSSGQMQMQMVLWGSLAAVAMFFLITFLVLLCSTCDREKKPRQHSGDHENLMNVPSDKDMFSHSATSLTTDALASSEQNGVLTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKAKCHQSRELPRIPPENAVDEILTARAADTELGPGVEGPYEVLKDSSSQENMVEDCLYETVKEIKEVADKGQGGKSKSTSALKELQGAPMEGKADFAEYASVDRNKKCRHSANAESILGTCSDLDEESPPPVPVKLLDENANLPQEGGGQAEEQAAEGTGGHSKRFSSLSYKSREEDPTLTEEEISAMYSSVNKPGQSAHKPGPCMKGPESACHSMKGLPQRSSSSCNDLYATVKDFEKTPNSISTLPPARRPSEEPEPDYEAIQTLNREDEKVPLETNGHHVPKESDYESIGDLQQCRDVTRL
Protein: H(+)-transporting two-sector ATPase (EC 7.1.2.2) (Mitochondrial protein YMF19) (Q2F996)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004304}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004304}.
Interaction partners:
Sequence:
MPQLDKLTYFSQFFWLCLFLFSFYILLLNNNNGILGISRILKLRNQLLSHRGNKIRFKDPKNLEDISRKGFSTGLSYMYSSLSEVSQWCKTVDYLGKRRKITLISDFGEISGSRGMERQILYLISKSSYNTSSSRITCWKKIMLTHVPHGQGSII
Protein: High mobility group protein B2 (High mobility group protein 2) (HMG-2) (P52925)
Organism: Rattus norvegicus (Rat)
Function: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity. May play a role in germ cell differentiation. Involved in modulation of neurogenesis probably by regulation of neural stem proliferation. Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P26583, ECO:0000255|PROSITE-ProRule:PRU00267}. Chromosome {ECO:0000250|UniProtKB:P26583}. Cytoplasm {ECO:0000250|UniProtKB:P26583, ECO:0000250|UniProtKB:P30681}. Secreted {ECO:0000250|UniProtKB:P26583}.
Interaction partners:
- Histone H2A.Z
Sequence:
MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEVGKKGPGRPTGSKKKNEPEDEEEEEEEEDDEDEEEEDEDEE
Protein: cysteine desulfurase (EC 2.8.1.7) (Q38DC4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Iron-sulfur cluster assembly protein, putative
- ferroxidase
- Acyl carrier protein
- Adenylyltransferase and sulfurtransferase MOCS3 homolog
- Cytochrome oxidase assembly protein, putative
Sequence:
MCSIEGPPLKKLRPQPLTPTDPIPIYLDYNATTPLCMESWRAMSAIVPFSWGNPSSVHPYGLAAKFVLDEARGKVANAIRAVTPANVIFTSGGTEANNLAIIGGFTALRERFPSRHYIITTNVEHPAVEEVLKFLEREHSAVVKGGDRRMSGGKKQQPPPVEVYRFPVDPRTGCVRTDEWRKLLLELPGGPQNVALVTVMHANNEIGGINPIDDLVKLVKEICGEETLFHTDAAQSIGKVPVNVSAMRVDMLSICSHKFYGPKGVGALYVRDGVRIRNILFGANHENGARPGTENVLLVTGMAEALHVACKNLTANAATMRNTRDELFRVIKQEVSKVGMDCVLNGDIDHALPNTLSVALFKVTDSGKRRYISAHGLIQAVGDKVCMSSGAACHSAEENVVVSASLRSVGVDLDRAVGTLRLSTGRTTTMAEVRRAARIIVRRAVQQFGEF
Protein: Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Plx1) (Polo-like kinase 1) (PLK-1) (P70032)
Organism: Xenopus laevis (African clawed frog)
Function: Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates cdc25, pkmyt1/myt1, stag2/sa2, tpx2. Plays multiple essential roles during mitosis. Phosphorylates the N-terminal domain of cdc25, which leads to cyclin b-cdc2 activation and mitotic entry. Also required for organization of bipolar spindles, and for exit from mitosis. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating stag2/sa2.
Subcellular location: Nucleus {ECO:0000269|PubMed:10567586}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10567586}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10567586}. Midbody {ECO:0000250}. Note=localization at the centrosome starts at the G1/S transition (By similarity). Localized at centrosomes at prophase, spindles at metaphase, and at the midbody during cytokinesis. Localization to the centrosome is required for S phase progression (By similarity). {ECO:0000250|UniProtKB:P53350}.
Interaction partners:
Sequence:
MAQVAGKKLTVAPEAAKPPGIPGSSSAVKEIPEILVDPRTRRRYLRGRFLGKGGFAKCYEITDLESREVFAGKIVPKTMLLKPHQKDKMTMEIAIQRSLDHRHVVGFHGFFEDNDFVYVVLELCRRRSLLELHKRRKAVTEPEARYYLKQTISGCQYLHSNRVIHRDLKLGNLFLNDEMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVDIWSIGCIMYTLLVGKPPFETSCLKETYMRIKKNEYSIPKHINPVAAALIQKMLRSDPTSRPTIDDLLNDEFFTSGYIPSRLPTTCLTVPPRFSIAPSTIDQSLRKPLTAINKGQDSPLVEKQVAPAKEEEMQQPEFTEPADCYLSEMLQQLTCLNAVKPSERALIRQEEAEDPASIPIFWISKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLIMYNDGDSLQYIERNNTESYLNVRSYPTTLTKKITLLKYFRNYMSEHLLKAGANTTPREGDELARLPFLRTWFRTRSAIILHLSNGTVQINFFQDHTKIILCPLMAAVSYIDEKREFRTYKLSLIQEFGCCKELASRLRYARTMVEKLQSSKSAVAHVKASA
Protein: Epithelial sodium channel subunit delta (Delta-ENaC) (ENaCD) (Epithelial Na(+) channel subunit delta) (Amiloride-sensitive sodium channel subunit delta) (Delta-NaCH) (Nonvoltage-gated sodium channel 1 subunit delta) (SCNED) (P51172)
Organism: Homo sapiens (Human)
Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:19520916}; Multi-pass membrane protein {ECO:0000269|PubMed:19520916}.
Interaction partners:
- Epithelial sodium channel subunit beta
- Epithelial sodium channel subunit gamma
- Epithelial sodium channel subunit alpha
- Cytochrome P450 4A11
- Sodium channel regulatory subunit beta-2
- Sodium channel protein type 4 subunit alpha
- Sodium channel regulatory subunit beta-1
- Sodium channel protein type 10 subunit alpha
- Sodium channel protein type 5 subunit alpha
- Sodium channel regulatory subunit beta-4
Sequence:
MRAVLSQKTTPLPRYLWPGHLSGPRRLTWSWCSDHRTPTCRELGSPHPTPCTGPARGWPRRGGGPCGFTSAGHVLCGYPLCLLSGPIQGCGTGLGDSSMAFLSRTSPVAAASFQSRQEARGSILLQSCQLPPQWLSTEAWTGEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
Protein: bZIP transcription factor TRAB1 (Protein ABA RESPONSIVE ELEMENT 1) (Q6ZDF3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription activator that mediates abscisic acid (ABA) signaling. Binds specifically to the ABA-responsive element (ABRE) of the EMP1 and RAB16A gene promoters.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Serine/threonine-protein kinase SAPK10
- Serine/threonine-protein kinase SAPK9
- Serine/threonine-protein kinase SAPK8
- Serine/threonine-protein kinase SAPK1
- Serine/threonine-protein kinase SAPK6
- Serine/threonine-protein kinase SAPK2
- Serine/threonine-protein kinase SAPK7
- Serine/threonine-protein kinase SAPK3
- Serine/threonine-protein kinase SAPK4
- Os05g0433100 protein
Sequence:
MDLKDGGGSERRGAAAGAGAGAAPLARQGSIYSLTFDEFQSTLGGMGGGLGKDFGSMNMDELLRSIWTAEESQAMASASAAAAAAEGGLQRQGSLTLPRTLSVKTVDEVWRDLEREASPGAAAADGGGGGGEQQQPRRQPTLGEMTLEEFLVRAGVVRENTAAAAAMVAAAAAPPVAPRSIPAVNNSSIFFGNYGGVNDAAAAAAGAMGFSPVGIGDPTMGNRLMSGVAGIGGGAITVAPVDTSVGQMDSAGKGDGDLSSPMAPVPYPFEGVIRGRRSGGNVEKVVERRQRRMIKNRESAARSRARKQAYTMELEAEVQKLKEQNMELQKKQEEIMEMQKNFFPEMQKNQVLEAVNNPYGQKKRCLRRTLTGPW
Protein: Homeobox protein DBX1-A (Developing brain homeobox protein 1-A) (Homeobox protein hlx1) (Q9PTU1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
Sequence:
MMIPSVIAPPAIYSAFMRPAASLHSPFPAHPSFLVEDLLRINRPSGFLSQTAHSPCASPPNSTPLSIPDNCRILDRVSPGITEKHGPCSPKTPVSSKDPTYLKFGVSAILAPSPKKATSPPSVHSIHPKGFSVPYFDGSFCPFVRSSYFPAPSSVVPIPGTFSWPLAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNRRMKWRNSKERELLSSGGCREQTLPTKTNPHPDLSDVGKKSSEDEDEDDACAPSHFCLSPRRVMSNSTDSSITFKHSDFSESEDEITVS
Protein: SNAP25 homologous protein SNAP29 (AtSNAP29) (Synaptosomal-associated protein SNAP25-like 2) (Q9SD96)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion.
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm {ECO:0000250}.
Interaction partners:
- Syntaxin-related protein KNOLLE
- Syntaxin-112
- Syntaxin-21
- Syntaxin-22
- Syntaxin-132
- Syntaxin-23
- Syntaxin-52
- Syntaxin-121
- Putative syntaxin-24
- Syntaxin-81
Sequence:
MAPKNSSWNPFDDEKEAAKSFSLNPFDDDDDDKEVEKRFTSSLKPSGGKENQTVQELESYAVYNSEETTKTVQGCLKVAEEIRCDASKTLVMLNEQGDQITRTHQKTVDLDHHLSRGEKILGRLGGVFSRTWKPKKSRSITGPVITKGDSPKRKVIDLKTREKLGLNPSLKPKSKTLPEAVDAYQKTQIAKQDEALTDLSALLGELKNMAVDMGTAIERQTNELDHLQDNADELNYRVKQSNQRARYLLRK
Protein: Pre-mRNA-splicing factor NTR2 (Nineteen complex-related protein 2) (NTC-related protein 2) (P36118)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Pre-mRNA-splicing factor SPP382
- Pre-mRNA-splicing factor BUD31
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- Pre-mRNA-splicing factor CLF1
- Pre-mRNA-splicing factor SYF1
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-processing protein 45
- Pre-mRNA-splicing factor CWC23
- Pre-mRNA-splicing factor ISY1
- Pre-mRNA-splicing factor 8
Sequence:
MAIKKRNKIRLPSGSPEEVGIDGSAHKPMQQIKPLVSNDSEDDDNDICVLQPIKFKKVPKRDITFDGEQAIKEDNSHYEDLYHSKKNTNASTRNKDDLLILNMEDLMEGNHHLLSDSSEAGSSSEGEHISSIPTRGEIAKLKAQKSLSRRKISESDVTTERDYVKLLDSEDKREIMETIRLNGGLKRNNEKEITNFSDDEMQGFQDEMLALTDNQIAIQKDSKRKIIEKAINEVPYRTNEEWETQLLSKGNINKSNEKIITPLPVLFPDDDESGNSIERINEMVSKICLQRKKVEMRLQALEKTKIDLEKSKASLINKLIGN
Protein: Adducin 1 (H0Y9H2)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
XVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGGPDNLVLLNPEKYKAKSRSPGSPVGEGTGSPPKWQIGEQEFEALMRMLDNLGYRTGYPYRYPALREKSKKYSDVEVPASVTGYSFASDGDSGTCSPLRHSFQKQQREKTRWLNSGRGDEASEEGQNGSSPKSKTKVWTNITHDHVKPLLQSLSSGVCVPSCITNCLWTKEDGHRTSTSAVPNLFVPLNTNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVVMDRSLVQGELVTASKAIIEKEYQPHVIVSTTGPNPFTTLTDRELEEYRREVERKQKGSEENLDEAREQKEKSPPDQPAVPHPPPSTPIKLEEDLVPEPTTGDDSDAATFKPTLPDLSPDEPSEALGFPMLEKEEEAHRPPSPTEAPTEASPEPAPDPAPVAEEAAPSAVEEGAAADPGS
Protein: Parathyroid hormone 2 receptor (PTH2 receptor) (Q91V95)
Organism: Mus musculus (Mouse)
Function: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Tuberoinfundibular peptide of 39 residues
- Parathyroid hormone
- Parathyroid hormone-related protein
- Parathyroid hormone/parathyroid hormone-related peptide receptor
- Guanine nucleotide-binding protein G
Sequence:
MAWLETFTYICGWLILSSCLLVRAQLDSDGTITIEEQIVLVMKAKMQCELNITAQLQEGEGNCFPEWDGIICWPRGTVGKMSAVPCPPYVYDFNHKGVAFRHCTPNGTWDSIHGSNKTWANYSDCFLQPDINIGKQEFFESLYILYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHLHLFVSFMLRAMSIFVKDRVAQAHLGVEALQSLVMQGDLQNFIGGPSVDKSQYVGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVSFFSDTKYLWGFISIGWGFPAVFVVAWAVARATLADTRCWELSAGDRWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDMRKQYRKLAKSTLVLVLVFGVHYIVFVCQPHSFSGLWWEIRMHCELFFNSFQGFFVSIVYCYCNGEVQAEVKKMWTRWNLSIDWKRAPPCGGQRYGSVLTTVTHSTSSQSQMGASTRLVLISGKPTKNACRQIDSHVTLPGYVWSSSEQDCQTHSPPEETKEGHRRQGDDSPVMESSRPVAFTLDTEGCKGETHPI
Protein: PTPRF interacting protein alpha 2 (A0A8I6AM56)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLTGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMVSSEGSTESEHLDGMEPGQKVHEKRLSNGSIDSTDDTSQIVELQELLEKQNYEMAQMKDRLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQMKMRTGSLIEPTISRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLGSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPSGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPRAIRMTHTLPSSYHNEARSLSASLEPDRLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGKKEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLDESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLTTTSGQSRKMTTDDVVFSVYTT