wanglab/gogpt-training-data huggingface dataset:
Protein: 18S rRNA (guanine(1575)-N(7))-methyltransferase (EC 2.1.1.309) (Bud site selection protein 23) (P25627)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of guanine 1575 (m7G1575) in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Required for efficient cleavage of the primary 35S precursor rRNA at site A2. Involved in positioning the proximal bud pole signal.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Multifunctional methyltransferase subunit TRM112
- Small ribosomal subunit protein uS5
- Ribosome biogenesis protein TSR1
- Essential nuclear protein 1
- Probable ATP-dependent RNA helicase DHR1
- Protein LTV1
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS15
- Dimethyladenosine transferase
- 20S-pre-rRNA D-site endonuclease NOB1
Sequence:
MSRPEELAPPEIFYNDSEAHKYTGSTRVQHIQAKMTLRALELLNLQPCSFILDIGCGSGLSGEILTQEGDHVWCGLDISPSMLATGLSRELEGDLMLQDMGTGIPFRAGSFDAAISISAIQWLCNADTSYNDPKQRLMRFFNTLYAALKKGGKFVAQFYPKNDDQVDDILQSAKVAGFSGGLVVDDPESKKNKKYYLVLSSGAPPQGEEQVNLDGVTMDEENVNLKKQLRQRLKGGKDKESAKSFILRKKELMKRRGRKVAKDSKFTGRKRRHRF
Protein: Duffy binding-like merozoite surface protein 2 (Q8IJ45)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MIYILSIVFYIFFLHIDIYVNIYSTCFVVNEGNPNLRNNIINDDELKGKAYNNTIDANNQNIEYNKNLKHNVNSSHISKFSDIMDQEDKGDNENSHDIKFEEKKNINKSLDAESNYGINEISITGNDSNSDNSNQNIFPDGSELAGGIPRSIYTINLGFNKCPTEEICKDFSNLPQCRKNVHERNNWLGSSVKNFSSDNKGVLVPPRRQSLCLRITLQDFRTKKKKEGDFEKFIYSYASSEARKLRTIHNNNLEKAHQAIRYSFADIGNIIRGDDMMDTPTSKETITYLEKVLKIYNENNDKPKDAKKWWTENRHHVWEAMMCGYQSAQKDNQCTGYGNIDDIPQFLRWFREWGTYVCEESEKNMNTLKAVCFPKQPRTEANPALTVHENEMCSSTLKKYEEWYNKRKTEWTEQSIKYNNDKINYTDIKTLSPSEYLIEKCPECKCTKKNLQDVFELTFDGKALLEKLKKEESPVSNSVNALPEPGQITLPDPSLKQTTQQENQPVVETPVTTAVINEHQGQTEPNKGDNNNERENHESNVGSIQEVNQGSVSEESHSKTIDPSKIDDRLELSSGSSSLEQHSKEDVKKGCALELVPLSLSDIEQIANESEDVLEEIEEEINTDGEIEYITEEEIKEDIEEETEEDIEEETEEETEEETEEEADEETVKEIEDKPEQEIKNKSLEEKQIDKNTDTSEKKGFNNSEKDEKARNLISKNYKNYNELDKNVHTLVNSIISLLEEGNGSDSTLNSLSKDITNLFKN
Protein: Dipeptidase 1 (DPEP-1) (EC 3.4.13.19) (Beta-lactamase) (EC 3.5.2.6) (Membrane-bound dipeptidase 1) (MBD-1) (Microsomal dipeptidase) (Renal dipeptidase) (P31428)
Organism: Mus musculus (Mouse)
Function: Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:P16444}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P16444}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P16444}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P16444}. Note=Brush border membrane. {ECO:0000250|UniProtKB:P31429}.
Interaction partners:
- Histone deacetylase 1
- Methyl-CpG-binding protein 2
- Chromodomain-helicase-DNA-binding protein 4
- Histone deacetylase 2
- Histone-binding protein RBBP4
- Histone-lysine N-methyltransferase SETDB1
- DNA helicase
- DNA
- Fibroblast growth factor 23
Sequence:
MVIIWWFWSLLAICASDSFRDQAVAIMRTTPVIDGHNDLPWQLLNLFNNQLLRPDADLNKLAQTHTNIPKLKAGFVGGQFWSAYMPCDTQNKDAVKRILEQMDVIHRMCQLYPETFMCVTNSSDILQAFRRGKVASLIGVEGGHLIDSSLGVLRTLYHLGMRYLTLTHNCNTPWADNWLVDRGDDEAESHGLSPFGKRLLNEMNRLGVMIDLSHVSVATMKDALQISRAPVIFSHSSAYSLCPHRRNVPDDVLQLVKNTSSLVMVNFFSNFVSCSDSATLPQVADHLDHIKKVAGAGAVGLGGDYDGVTMLPVGLEDVSKYPDLIAELLRRNWTETEVRGLLADNLIRVFSEVELVSNNMQSPEEVPITLKELDGSCRTYYGYSQAHSIHLQTGALVASLASLLFRLHLL
Protein: Dynein axonemal assembly factor 4 (Dyslexia susceptibility 1 candidate gene 1 protein homolog) (Q8R368)
Organism: Mus musculus (Mouse)
Function: Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity (By similarity). Axonemal dynein assembly factor required for ciliary motility.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8WXU2}. Cytoplasm {ECO:0000269|PubMed:23872636}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q6AZN0}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q5VJS5}.
Interaction partners:
- Dynein axonemal assembly factor 6
- Dyslexia-associated protein KIAA0319 homolog
- Doublecortin domain-containing protein 2
- Dynein axonemal assembly factor 3
- Dynein axonemal assembly factor 1
- Zinc finger MYND domain-containing protein 10
- Dynein axonemal assembly factor 5
- Dynein axonemal assembly factor 11
- Dynein axonemal assembly factor 19
- Dynein axonemal intermediate chain 2
Sequence:
MPVRVSEFSWQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWDSLSVPGVDKEMMQRIREKSILQAQEKAKEATEAKAVAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATSELEAWKECQKKADGQKRVQRKEKPLEGKQAEETKALKPRGLPRKAPPTRLPTRGRNWENIFPEKLKEDRVPAPRSAGSIQISFTPRVFPTALRESQVAEEEEWLHKQAEARRAMSTDLPEFFDLKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELLTPPVADNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQNDAEKIRNIIQGTALKSRD
Protein: Kinesin light chain (A4IG65)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367020}.
Interaction partners:
Sequence:
MSTMVYPRDEALERLTQDDIVLNTKAVMQGLETLRGEHAQLLNTILDCSQPAGAQEKSRLLRKSLEDIELGLGEAQVIIALSGHLSAVESEKQKLRAQVRRLCQENQWLRDELANTQHKLQKSEQSVAQLEEEKKHLEFMNQIRKLDEDTSPSEEKAGEKEKDNLDDLFPNDDDQGPAQPSGEVAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKHKEAEPLCKRALEIREKVLGKFHPDVAKQLNNLALLCQNQGKYEEVEYYYRRALEIYENKLGADDPNVAKTKNNLATCYLKQGKFKDAETLYKDILTRAHEKEFGSVNNDNKPIWMHAEEREESKGKRKDSGPYGEYGSWYKACKVDSPTVNTTLKSLGALYRRQGKLEAAETLEVCATKNRKQGIDVINQSKMVELLKDGGGAGGDRRQSRDGVNGPGGPRGDCDGDEAEWSGDGNGGLRRSGSFGKIREALRRSSEMLVKKLQGSGPQEPRNPGMKRASSLNFLNKSAEETSQESNNSLSESRGLSASNVDLTRRNSLIS
Protein: UPF0053 protein Rv2366c (P9WFP1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Endoribonuclease YbeY
- Cytidine deaminase
- PhoH-like protein
- GTPase Era
- Dihydropteroate synthase
- Uncharacterized protein
- Transcriptional activator protein
Sequence:
MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYVNLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAYSISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNGPFASEIELREVVDLAQQRGVVAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGENVDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEEIVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGELYGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLHAEGGTDHRGRVRIGTVLLSPAEPDGADDEEADHPG
Protein: histidine kinase (EC 2.7.13.3) (Q7CY45)
Organism: Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Interaction partners:
- Two component response regulator
- histidine kinase
- histidine kinase
- histidine kinase
- histidine kinase
- Sensory/regulatory protein RpfC
- histidine kinase
- histidine kinase
- histidine kinase
Sequence:
MSSHTPKLDSCGAEPIHIPGAIQEHGALLVLSAREFSVVQASDNLANYIGVDLPIGAVATEANLPFISVLSAWYSGEESNFRYAWAEKKLDVSAHRSGTLVILEVEKAGVGESAEKLMGELTSLAKYLNSAPSLEDALFRTAQLVSSISGHDRTLIYDFGLDWSGHVVAEAGSGALPSYLGLRFPAGDIPPQARQLYTINRLRMIPDVDYKPVPIRPEVNAETGAVLDMSFSQLRSVSPVHLEYMRNMGTAASMSVSIVVNGALWGLIACHHATPHSVSLAVREACDFAAQLLSMRIAMEQSSQDASRRVELGHIQARLLKGMAAAEKWVDGLLGGEGEREDLLKQVGADGAALVLGDDYELVGNTPSREQVEELILWLGEREIADVFATDNLAGNYPTAAAYASVASGIIAMRVSELHGSWLIWFRPEVIKTVRWGGDPHKTVQESGRIHPRKSFEIWKEQLRNTSFPWSEPELAAARELRGAIIGIVLRKTEEMADLTRELQRTNKELEAFSYSVSHDLRAPFRHIVGFAQLLRERSDALDEKSLHYLQMISEAALGAGRLVDDLLNFSQLGRTQLTLKPVDMQKVVSEVRRSLSHAVSDRQIEWRIGALPVIFGDPTLLRQVWYNLIENAIKYSSREPVSIITISAVETEDDVTYSVEDNGVGFDMAYYNKLFGVFQRLQRVEDFEGTGIGLALVRRIVERHHGLVGAEGTVGEGATFSFTLPVTKVEEEKIA
Protein: RNA binding protein, mRNA processing factor (E5RFP4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAFTYPASLHAQCFSPEAKPNTPVFCPLLQQIRFVSGNVFVTYQPTADQQRELPC
Protein: Activator of HSP90 ATPase activity 1 (G3V438)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPALKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF
Protein: Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) (Q64701)
Organism: Mus musculus (Mouse)
Function: Key regulator of entry into cell division (By similarity). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation (By similarity). May act as a tumor suppressor (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transcription factor E2F4
- Cyclin-dependent kinase 2
- Transcription factor E2F5
- Transcription factor Dp-1
- Transcription factor E2F1
- G1/S-specific cyclin-E1
- Transcription factor Dp-2
- Transcription factor E2F2
- Transcription factor E2F3
- Retinoblastoma-like protein 2
Sequence:
MFEDEPHAEGAAAVAAAREALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVIHWLACSLYVACRKSIIPTVGKGVMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKFEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRRDLLNPSFKGLPSDFHAPDFKAAEEPPCIIAVLCDLHDGLLVEAKGIKEHYFKPYISKLFDKKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTADTPFGKLTSQASVECNLQQHFEKKRSFAPSTPLTGRRYLQEKEAVTTPVASATQSVSRLQSIVAGLKSAPSEQLLNIFESCMRNPMGNIIKIVKGIGETFCQHYTQSTDKQPGSHIDFAVNRLKLAEILYYKILETIMVQETRRLHGMDMSVLLEQDIFHKSLMACCLEIVLFAYSSPRTFPWIIEVLDLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWTNNSALWEALHASANRVPSCEEVIFPNNFEIGNGGNVQGHLPMMPMSPIIHPRVKEVRTDSGSLRQDMQPLSPISVHERYSSPAAGSAKRRLFGDDPPKDTLMDKIMAEGTKLKIAPSSVTAESLSISPGQALLTMATTTVTGTTGRKVTVPLHGIANDAGEITLVPISMNPTQESTAESPVSLTAQSLIGTSPKQTHLTKAQDAHLTGVSKPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPGGVVVYNGDCEMTDGDIEDATKTPNCSSEPVKEERGDLIKFYNTVYVGRVKSFALKYDLSNQDHIMDAPPLSPFPHIKQQPGSPRRISQQHSLYVSPHKNGAGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQKTKKRVIAISGDADSPAKRLCQENDDVLLKRLQDVVSERANH
Protein: Deoxyhypusine synthase (EC 2.5.1.46) (Q38BX0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: In association with the non-catalytic regulatory subunit DHSp, catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF5A precursor protein to form the intermediate deoxyhypusine residue. Regulates protein levels of its regulatory subunit DHSp. Required for cell growth and survival.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Eukaryotic translation initiation factor 5A
- Deoxyhypusine synthase regulatory subunit
- Deoxyhypusine hydroxylase
- S-adenosylmethionine decarboxylase proenzyme-like, putative
- S-adenosylmethionine decarboxylase proenzyme
Sequence:
MAELAKSAVLVSSCTDDLLGDAKQVVVGPNQEDLHSAEAVLNRYSTVGFQASNLARAFSICEMMLTPQSPSPSLMPTEGDQASESPVMVQPTLFVGVTANLFGTGCREAIRFLCTECVPLPNGVEPATPLDDMAGISCDGTGALKPSPCDSRALIHVLVVSGGAMEHDIRRACESYKLSRDGAEEEGEQFHHPVERDRSRSKGTDCHFGNVRYNSSGVASRNLFSCVMRCLVKRLAEAQRKEKANREAAPIPEAYYDVCSWAITPSTLWYMAGLWMADIFTEALQETGEVTDEKVASEEGLKRAKSTVLYWAARNGVPIFSPSLTDGDIMEFILTAGDTGVPLLQLDLVADIHRLNRLAMRSRRTGMMILGGGVVKHHVCNANLMRNGADYAVFLNNAQEFDGSDAGARPGEAVSWGKLRLDSTAVKVYSEVTIVFPLIVVHVFVAWVRMMRSKGKENIRS
Protein: Variant surface glycoprotein (VSG), putative (Q38G46)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MRSLIANLLTALVALTSVAHSARENAQEYEALCAAYQAATGTIEPADFNTAQADAEVPTAVKALYAATIPDEHYNNKTFGIFTTDTEFTAVKDTVKTEKNIDKSPVYTRPPESPGKRAALTALERLYNSTKATAGQAAEKQKELQSLKEKAEKFLKAAVFGHETATEAKEENFDTRANACNGGGNAKAASQNLAQALACVCGTASTNNGICVQGEDQANYGTGSGASAGVSAYKAIVAKCQPATEPKKVTAELLTAAVSQVESVLGNKAFTGHTNNGRYVLGNGAAANCNGGDSSATCIDYTTTVGTGTFHKVKWVENMLQATKELKKAYTIRAEQAKMQAQLEAAEAQAWQLRDTLAIATITAAHAAETIKPSKRQRQETIDSKEAECNTKDKDTDCKPPCAWNAEAKDEKKRCTLSEKGKEAAEKVAANQAGTDGKNESKCGEAKTEDECKKVPGKTPEGKKAVCGWIEGKCQDSSILASKQFALSVVSAAFVALLF
Protein: Anaphase-promoting complex subunit 2 (Q38DN8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cyclosome subunit 1, putative
- Cell division cycle protein 16, putative
- Anaphase-promoting complex subunit 11
- Cdc23 domain-containing protein
- Ubiquitin-conjugating enzyme E2, putative
- E2 ubiquitin-conjugating enzyme
- Anaphase-promoting complex subunit 10
- Uncharacterized protein
- Uncharacterized protein
- Non-specific serine/threonine protein kinase
Sequence:
MEEDEAFANLVGVLQVVKSDGVSAFQYPDVAVKYRFNESLAVLSKPPLNVAAAELLVRKVFEVFADTTIVEYQRDMCSGRESLALRHLHERYQQTFAIISDWCGRLNSEESVALFTVSLRCHLLQPDLLTDESPPGKKELLSFLELHGHRVLKSIEEAGSAHSFTRVVDGSCDEVLQELHDLTLSSTSDIKALWKSVLVNCTLDRIASLDDDDFTVARIQSYMQWKDDVVDVFVRMALSPDPDDSEQRSEVNRWCKDLEQLLLVSYGQKRIASFWDVVVEYPDSTPTLQDLRFCLQRCTDDTLRNGLIKTVKWMLVSRLHRAGTRTEDILAILIGTIHSLCVLVPKNDQSSMIFTIVGDTLEHLKKRKDCVSAVVQAMTQPSGDSTLNIDLRNYASTGSALDNGDSFEGVWDATLPGTEQSSLSLHEKPDVLRVLLATISVNSLVEEYRQVLASQLLGKPMHNFDTSAEEEVLERLKCAFGEDVLAPCVVMIRDIQASRRYTQQLGEMHEGRATSDKTSSVESRRDWPLSLDVLSTTSWPKLSSCLPAGETQPIPDKYNPHPELASAMDDAKEGYKRLKANQRLEWVLSHGNVTLELQQKEVSASRFVAVTYDLSLFSASIVLYVRDISAEVDAPAPLVAVAERMGVKPQVLQQRISHLIPSVLLSADDNKTLSVQTNYVSTSNFTFDDAEEGEEQPAGLSPDQMNMLLSMLKAMLKAREACGASDIFNSMKMFGQFQGSIDDMRRLLQIFVAQGKLAVNEAKLYTLPKG
Protein: WD repeat domain 62 (F1LRR4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton, spindle pole {ECO:0000256|ARBA:ARBA00004647}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Assembly factor for spindle microtubules
- Centrosomal protein of 63 kDa
- Centrosomal P4.1-associated protein
- STIL, centriolar assembly protein
- Microcephalin
- Dual specificity mitogen-activated protein kinase kinase 7
- Centrosomal protein 135
Sequence:
MMAALAAGGYARSDTIEKLSSVMAGVPARRNQSSPPPAPPLCLRRRTRLAAAPEDTVQNRVTLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEASTEAKVTSTMPLVGRSGILGELHNNIFCGVACGRGRMAGNTFCVSYSGLLCQFNEKRVLDKWINLKVSLSSCLCVSDELIFCGCTDGIVRIFQAHSLLYLTNLPKPHYLGIDVAQGLDSSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSVYIWDVKDINEVSKIWSELFHSSFVWNVEVYPEFEDQRACLPSGTFLTCSSDNTIRFWNMDSGSDTQWRKNIFSDSLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDMKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKPETGVTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGTRDVQMISCGADKSIYFRSAQQTSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNGWSLRQTAQGDMCLFPQVHVDPSGTFLATSCSDKSISVIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHLGPEITTCMKQHLMEINHQEQQHLPKDQKWSGPPSQETSASTPSEIRSLSPGEQTEDEMEEECEPEETLKTPSKESLDPDPRCLLTNGKLPLWAKRLLGDDDVTDSSAFHAKRSYQPHGRWAERAEQEPLKTILDAWALDSYFTPMKPGNLEDSVLDSVEPQNLAGLLSECSPENGHTAPGEGLVSYLCHSESGSPKEDSRGHPSYLPLQREGTETRELILCSPEVEVTVTGMHREYYEEAEAGPEDQQGDSYLRVSSVSSKDQSPPEDSGESEAELECSFAAAHVSAPRTDPGPHLTMTGKPEHSSTDELAQPGVPGLGNGSLPQTPEQEKFLRHHFETLTDAPAEELFPGSLGDIKISETDDYFFNPRLSISTQFLSRLQKTSRFPPRLPLHLMKSPEVQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQMAEETPEASCLPTPPITGLASCVPPSSVIPTDRKPPTPTSGLTTGREQSIPAPSPCSYLESTTSSHAKMTRSTSLGDSEGPVTGELPRPLHKPVSPGQEPQAVPTTVALTSSVKGHEPALPAWGNHEARASLRLTLSSVCEQLLSPPQLEPPTTPVWSQEAVDVPPSMAVTVASFSAPSPEDMSTLGLHSSVFLPKTSASGPLTPPAHPNSLQLLETRSRMPGSTPALLEPTPDASSGSPDSPGHCGEPGRRAEVPPPGPLELDSVESVLYRLQTAFQEALDLYRMLASSNQLGAEQQQAQTELASAFHWIHHQLEASNCVGAASVAPPLTLPSPGPPSPPTLCPLASPNLQALLEHYSELLVQAVRRKVRGD
Protein: Protein Wnt-8b (Q93098)
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Interaction partners:
- Secreted frizzled-related protein 5
- Protein-serine O-palmitoleoyltransferase porcupine
- Secreted frizzled-related protein 1
- Wnt inhibitory factor 1
- Palmitoleoyl-protein carboxylesterase NOTUM
- Frizzled-2
- Glypican-3
- Cerberus
- Low-density lipoprotein receptor-related protein 5
- Frizzled-1
Sequence:
MFLSKPSVYICLFTCVLQLSHSWSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCSRAERPRGGAAHKPGRKP
Protein: COP9 signalosome subunit 7A (F5H248)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEAPRERQDLVQVELKGLSFPPWGCGVPAACLPLRSPQRAFCAPGQLIILGS
Protein: Neurexin-3-beta (E1B6S6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MMMAHSIDENPNEALIESLAPSCLSLEEQQSCFIDTDDSTGFFSPVLPTVANFPTTRQTEHIDNEVTALITSSLAPQKTRPKSTPHFTVYPVRPTTPMGDTITTTMQAATVTDFPRTPLIMCSSLAVIIAIAAVVFFVFKCRQNPPNSEHYTMAMKSQSGYTAIAPELSPPMNHDRSNDSCTQPLLAKPHINGNGYEPLKGAVIANGNGATATMMRNGNGNGVAKKKDFKEWYV
Protein: Zinc finger and SCAN domain-containing protein 31 (Zinc finger protein 323) (Q96LW9)
Organism: Homo sapiens (Human)
Function: May function as a transcription factor. May be involved in the development of multiple embryonic organs.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MASTEEQYDLKIVKVEEDPIWDQETHLRGNNFSGQEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVVEDLEQELSEPGNQAPDHEHGHSEVLLEDVEHLKVKQEPTDIQLQPMVTQLRYESFCLHQFQEQDGESIPENQELASKQEILKEMEHLGDSKLQRDVSLDSKYRETCKRDSKAEKQQAHSTGERRHRCNECGKSFTKSSVLIEHQRIHTGEKPYECEECGKAFSRRSSLNEHRRSHTGEKPYQCKECGKAFSASNGLTRHRRIHTGEKPYECKVCGKAFLLSSCLVQHQRIHTGEKRYQCRECGKAFIQNAGLFQHLRVHTGEKPYQCSQCSKLFSKRTLLKKHQKIHTGERP
Protein: Uncharacterized protein (Q389T7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Rhodanese domain-containing protein
- Uncharacterized protein
- Ribosomal protein S23 mitochondrial conserved domain-containing protein
- Trans-sialidase
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MMQKSVTFLRRGKPRPRAGMFPDKYRRVPMLLKPQQGGQQYFNHFLIRSTNDRLTQQDVDNASGQAHSFISPQLPQMDWRNMSARSSEESIREEMRQLAENDVMQHQRVFNERMWYEKEEEHRMKARSCPEETSEHAISNDGAVPPPRVLGGDYFKTRFGYSLVKNSEMTQGPVDYSQLDMWGEMPRYTSDMVFLYLVSRRRNTYAVAYTYEGKRILNTYTAGNRGLKGGDRGFRSEGSTDNGHQVTSMYLNDLLPKLREMRASEGRPMGRGEKVELVVRVMGFYNGRQGAVRAVQDRANEFHVRYFEDITPFPLNGPKMPRGVFK
Protein: Deubiquitinase otu (EC 3.4.19.-) (Protein ovarian tumor) (P10383)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for female fertility; germ cell division and differentiation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11287191, ECO:0000269|PubMed:1737618, ECO:0000269|PubMed:30879902, ECO:0000269|PubMed:7851643}. Cytoplasm, cell cortex {ECO:0000269|PubMed:7851643}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11287191}. Note=There is contradictory evidence of what happens to otu localization in nurse cells during vitellogenesis; either it relocalizes to the region of the cell cortex in close apposition to surrounding follicle cells or it takes on a granular perinuclear localization pattern (or both occur and can only be visualized under certain experimental conditions) (PubMed:11287191, PubMed:7851643). Forms stable amyloid-like granules in the cytoplasm (PubMed:30879902). {ECO:0000269|PubMed:11287191, ECO:0000269|PubMed:30879902, ECO:0000269|PubMed:7851643}.
Interaction partners:
- Maternal effect protein oskar
- Vitellogenin receptor Yl
- Tubulin alpha-4 chain
- Protein bag of marbles
- Poly
- Thioredoxin-1
- Chorion peroxidase
- Female sterile
- CG5272 protein
- Protein matrimony
Sequence:
MDMQVQRPITSGSRQAPDPYDQYLESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRFMTLKRRIFEKEIPGDFDSYMQDMSKPKTYGTMTELRAMSCLYRRNVILYEPYNMGTSVVFNRRYAENFRVFFNNENHFDSVYDVEYIERAAICQSIAFKLLYQKLFKLPDVSFAVEIMLHPHTFNWDRFNVEFDDKGYMVRIHCTDGRVFKLDLPGDTNCILENYKLCNFHSTNGNQSINARKGGRLEIKNQEERKASGSSGHEPNDLLPMCPNRLESCVRQLLDDGISPFPYKVAKSMDPYMYRNIEFDCWNDMRKEAKLYNVYINDYNFKVGAKCKVELPNETEMYTCHVQNISKDKNYCHVFVERIGKEIVVPYESLHPLPPDEYRPWSLPFRYHRQMPRLPLPKYAGKANKSSKWKKNKLFEMDQYFEHSKCDLMPYMPVDNCYQGVHIQDDEQRDHNDPEQNDQNPTTEQRDREEPQAQKQHQRTKASRVQPQNSSSSQNQEVSGSAAPPPTQYMNYVPMIPSRPGHLPPPWPASPMAIAEEFPFPISGTPHPPPTEGCVYMPFGGYGPPPPGAVALSGPHPFMPLPSPPLNVTGIGEPRRSLHPNGEDLPVDMVTLRYFYNMGVDLHWRMSHHTPPDELGMFGYHQQNNTDQQAGRTVVIGATEDNLTAVESTPPPSPEVANATEQSPLEKSAYAKRNLNSVKVRGKRPEQLQDIKDSLGPAAFLPTPTPSPSSNGSQFSFYTTPSPHHHLITPPRLLQPPPPPPIFYHKAGPPQLGGAAQGQTPYAWGMPAPVVSPYEVINNYNMDPSAQPQQQQPATLQPAPLSVQSQPAAVYAATRHH
Protein: MICOS complex subunit MIC10 (Mitochondrial contact site complex 10 kDa subunit) (Mitochondrial inner membrane organization component of 10 kDa) (Mitochondrial organizing structure protein 1) (MitOS1) (Q96VH5)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:21944719, ECO:0000269|PubMed:21987634, ECO:0000269|PubMed:22009199, ECO:0000269|PubMed:22114354}; Single-pass membrane protein {ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:21944719, ECO:0000269|PubMed:21987634, ECO:0000269|PubMed:22009199, ECO:0000269|PubMed:22114354}. Note=The C-terminus is located in the intermembrane space, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (PubMed:22114354). Enriched at crista junctions. {ECO:0000269|PubMed:22114354}.
Interaction partners:
- MICOS complex subunit MIC19
- MICOS complex subunit MIC27
- MICOS complex subunit MIC60
- MICOS subunit MIC26
- MICOS complex subunit MIC12
- Sorting assembly machinery 50 kDa subunit
- ATP synthase subunit e, mitochondrial
- Mitochondrial import receptor subunit TOM40
- Altered inheritance of mitochondria protein 24, mitochondrial
- ATP synthase subunit g, mitochondrial
Sequence:
MSEQAQTQQPAKSTPSKDSNKNGSSVSTILDTKWDIVLSNMLVKTAMGFGVGVFTSVLFFKRRAFPVWLGIGFGVGRGYAEGDAIFRSSAGLRSSKV