wanglab/gogpt-training-data huggingface dataset:
Protein: Calmodulin-like protein 4 (Q9LX27)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Potential calcium sensor.
Interaction partners:
- Probable calcium-binding protein CML22
Sequence:
MVRVFLLYNLFNSFLLCLVPKKLRVFFPPSWYIDDKNPPPPDESETESPVDLKRVFQMFDKNGDGRITKEELNDSLENLGIFMPDKDLIQMIQKMDANGDGCVDINEFESLYGSIVEEKEEGDMRDAFNVFDQDGDGFITVEELNSVMTSLGLKQGKTLECCKEMIMQVDEDGDGRVNYKEFLQMMKSGDFSNRS
Protein: EG45-like domain containing protein 2 (Plant natriuretic peptide A) (AtEXPR3) (AtPNP-A) (Ath-ExpGamma-1.2) (Q9ZV52)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a systemic role in water and solute homeostasis.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
- Leucine-rich repeat
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- Protein LURP1
- Nudix hydrolase 6
- Aspartyl protease AED1
- ER membrane protein, putative
Sequence:
MIKMAVKFVVVMIVFAQILAPIAEAAQGKAVYYDPPYTRSACYGTQRETLVVGVKNNLWQNGRACGRRYRVRCIGATYNFDRACTGRTVDVKVVDFCREPCNGDLNLSRDAFRVIANTDAGNIRVVYTPI
Protein: Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) (Q5AMQ4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the final step in the biosynthesis of the membrane lipid glucosylceramide (GluCer), the transfer of glucose to ceramide. Glucosylceramides play important roles in growth, differentiation and pathogenicity.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9R0E0}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Inositol phosphosphingolipid phospholipase
- Sphingolipid delta
- Delta 8-
- Serine C-palmitoyltransferase
- serine C-palmitoyltransferase
Sequence:
MVQEELSLFRITTGYFFLLWYIIILVAAYSGFFEILFNFRNRPILHTKQQANHQNDPESDDEEIYEGVTIIRPIKGIDPELTSCLESSFCQNYPRSKLQILFCVDDPNDPSIPIIQKLIAKYPTVDAQILTSESYNSQTKTSDDHYGPNPKVNNLAKGFVHAKYDILWVMDSNVWASSNILKNSVISLNGNLNMSRKMGQSRPVKLVHHVPLALSINNTTRSDDFIGGQDLEITAMTPVPSSESLNSQLVKRKSSPKSNNSLNVHPGFTYSKFSKKLGAELDEMFLHTSHSKFYVSLNNLAVAPCVNGKSNIYRRSDLDQSVRLIPHKDSPFFKDPKVKQDAGYYTSLGVGHAIKFFARYIGEDNMIGIALWENTQGRTGLTGDVVVQPYSGSENNAVKDYIQRRVRWLRVRKYMVLLATLIEPTTESIICGIYGTYAISTVFFGTWFNKYWFVMHMLIWMLTDYVQYHTLINHTLDVKNITYLPNWLNESIPPKQRNCLQWGYIWILRELLALPIWIIAMIGHEIDWRGRPFRIKKDLTAEEM
Protein: PHD finger protein-like protein (F4HWW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAIARTGVYVDDYLEYASTFPAELQRLLNTVRELDERSQSLINQTRQQTKYCLGLASQSSKKGNGNHYNNGGLDEEETIEKMRKEIESSQENALSLCTEKVLLARQAYDLIDSHVKRLDEDLNNFAEDLKQEGKIPPDEPSVLPPLPIVPKAEKRKSFYGTPQPKKIDYRDRDWDRDRDFELMPPPGSNRKDLMPIEEQPIDPNEPTYCVCHQVSFGDMIACDNENVSLLSQHLIIYFLMYSCYDETFCSCFDSAKEVNGFTIHALASHLRPDSKGNGTAPPADSSHSHTNIICTCEKVPLASSLAPSLHDQCHQTHLSCYPTSSKCK
Protein: Ammonia transport outward protein 3 (Q12359)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transporter protein required for ammonia export. Induced in rho(0) cells, probably to eliminate the excess ammonia that arises because of a potential defect in ammonia assimilation in those cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12966084, ECO:0000269|PubMed:17395151}; Multi-pass membrane protein {ECO:0000269|PubMed:12966084, ECO:0000269|PubMed:17395151}. Note=Localizes to large detergent resistant patches of the cell membrane (DRM) enriched in ergosterol and sphingolipids.
Interaction partners:
Sequence:
MTSSASSPQDLEKGVNTLENIETLPQQGSIAGVSQGFPNIQEIYSDRDFITLGSSTYRRRDLLNALDRGDGEEGNCAKYTPHQFANPVPLGLASFSLSCLVLSLINANVRGVTDGKWALSLFMFFGGAIELFAGLLCFVIGDTYAMTVFSSFGGFWICYGYGLTDTDNLVSGYTDPTMLNNVIGFFLAGWTVFTFLMLMCTLKSTWGLFLLLTFLDLTFLLLCIGTFIDNNNLKMAGGYFGILSSCCGWYSLYCSVVSPSNSYLAFRAHTMPNAP
Protein: Zinc knuckle (Q57US0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MYGNKGPPRKYSTPRGVDETSNAKKTCQKCGSKAHWTFECKGVTPSRGAATTRLSRTQQLRWGIKQQRQEFVPEPTEWEAYKERVKGVERQLVAEARAEVSQKKQRLEDRTGVKRESEEQSDMKVIIKEEDNTHNAKKTFKTEE
Protein: Lipophorin receptor 1, isoform S (A8JRD2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MGRIWCLLFVSSLLHTQSQSFRVLAINEATCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELCMNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAHCNQTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDPLYLPPVTRPPRARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVADQRPVKNHTQIEKTTTPSEQPDSGFIALVVIASLSGFAVLLSVLLLIGYRYCSKRRINSMNFENPIYRKTTTTEDHFSLRKNLPARIYDHTSVMDEEYSPVIGISSY
Protein: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I) (P27808)
Organism: Mus musculus (Mouse)
Function: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:P26572}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P26572}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P26572}. Note=Co-localizes with BRI3 at the perinuclear region. {ECO:0000250|UniProtKB:P26572}.
Interaction partners:
- Alpha-mannosidase 2
- Alpha-mannosidase 2x
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- alpha-1,2-Mannosidase
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
- Probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7
Sequence:
MLKKQTAGLVLWGAIIFVGWNALLLLFFWTRPAPGRLPSDSALGDDPASLTREVIHLAEDAEAELERQRGLLQQIKEHYALWRQRWRVPTVAPPAWPRVPVTPSPVQIPILVIACDRSTVRRCLDKLLHYRPSAERFPIIVSQDCGHEETAQVIASYGTAVTHIRQPDLSNIAVQPDHRKFQGYYKIARHYRWALGQIFNKFKFPAAVVVEDDLEVAPDFFEYFQATYPLLRTDPSLWCVSAWNDNGKEQMVDSSKPELLYRTDFFPGLGWLLLADLWAELEPKWPKAFWDDWMRRPEQRKGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVPFTQLDLSYLQQEAYDRDFLAQVYGAPQLQVEKVRTNDQKELGEVRVQYTSRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPQTWTGYDPSWN
Protein: Na/Ca-exchange protein, isoform I (A0A0B4LHD9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MQLLLKSIFTCALFVIFVYATAQSLLKVQETEARQAYLNVTSSSSSNLSQDDGHFLSRRLRQVSHGEEGDEGAPSQMDDELEQMTKVHGEAPDAEELRECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNKRGTVVAGEHDQVEMDAEKGPKQPMVTSARGNDAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPDSTHYRKP
Protein: Ephrin type-B receptor 6 (MEP) (Tyrosine-protein kinase-defective receptor EPH-6) (O08644)
Organism: Mus musculus (Mouse)
Function: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity).
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Interaction partners:
- Ephrin-B3
- Ephrin-B1
- Ephrin-B2
- Ephrin-A1
- Ephexin-1
- Ephrin-A3
- Ephrin-A5
- Ephrin type-B receptor 1
- Ephrin-A4
- Tyrosine-protein kinase ABL1
Sequence:
MATEGTTGSGSRVVAGMVCSLWLLVLGSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGLPPGSGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQADEPDGPDSIAAWHLKRWTKVDTIAADESFPASSSSSSWAVGPHRTGQRVGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVKLFSYTCPSVLRAFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGRWMVAVGGCRCQPGHQPARGDKLCQACPEGSYKALAGNVPCSPCPARSHSPDPAAPVCPCLQGFYRASSDPPEAPCTGPPSAPRELWFEVQGSALMLHWRLPQELGGRGDLLFNVVCKECGGHGEPSSGGMCRRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVMHQVSRAANSITVSWPQPEQTNGNILDYQLRYYDQAEDESHSFTMTSETNTATVTRLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPEKLSLVIGSILGALAFLLLAAITVLAVIFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYDDPCQAIRELAREVDPTYIKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLGHSPQGSSSLLRWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAEGGSGDRPSQALLNPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLSTFSDVAQLSLEDLPGLGITLAGHQKKLLHNIQLLQQHLRQPGSVEV
Protein: Lysophospholipase (EC 3.1.1.5) (G8BA46)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- Glycerophosphodiester phosphodiesterase
- Lysophospholipid acyltransferase
- Lysophospholipase NTE1
Sequence:
MKALHILCASAAVLAQAQAIWPFDSGSSSSTNSDSTETSQPSDDGESWFQSVVGNFGGDGSESSSTEGAASTDDSNPYAPFNTTCPSGSLTRDANDISDLEKNYIQKRQEITNKNLIDFLQKKSNLTDFDAESFINDNAKDHNITIGLAFSGGGYRAMLCGAGQLLATDDRFEDANEHGVGGLLQSATYITGLSGGNWLVGSLVMNNWLSVAEIVNGSSSIWQLEDSILNPSGIRIDKTIAYYYGLREAVLAKEEAGFDTTITDIWGRALSYQFFPDESGGENITWSSVRNMSHFEDHTMPYFMVVSNARKPGDLIINENSTVIEVSPYELGSWDPSLNAFADVEYLGSSVHSGNPNDTNICVRNFDNAGFIMGTSSSLFNQVLLQLGNYDINSVIKSILTGLLSRLSYAEWDIASYEPNPFFGQESGESVAMIKNETLYLVDGGEDLQNVPFYPLIQNTRDVDVIFAFDNSADTDESWPNATSIISTYKRQFAQQGKGTPFPFVPDVETFLDEDLSSKPVFFGCNASDLDALITWHNNSDVNATDVPLVVYVSNHHESYYSNFSTFKLSYENAEKYGAIRNGFEVMSRNNLTDDDKWLTCVGCAIIRRQQERFGQEQSDECKQCFKEYCWNGGVKEAAAVSSASGLSEITGLRTSSAHSTSSSTATSSPASSETTSKTSSSSDNESTSSENSSSSKQNDGVINKGQPSFFFLLGNLLLAILAN
Protein: RE50839p (Spliceosomal protein on the X) (Q9W424)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Splicing factor 3B subunit 5
- Splicing factor 3A subunit 2
- Splicing factor 3B subunit 3
- PHD finger-like domain-containing protein 5A
- Splicing factor 3B subunit 1
- LD45152p
- LD21442p
- Splicing factor 3A subunit 1
- Splicing factor 3B subunit 6
- Probable U2 small nuclear ribonucleoprotein A'
Sequence:
MAAGPIAERNQDATIYAGGLDDKVSETLLWELFVQAGPVVNVHMPKDRVTQMHQGYGFVEFLSEEDADYGIKIMNMIKLYGKPIRVNKASAHQKNLDVGANIFIGNLDVEVDEKLLYDTFSAFGVILQTPKIMRDPETGKSKSFAFINFASFEASDAAMDAMNGQYLCNRPISVSYAFKKDHKGERHGSAAERLLAAQNPSTHADRPHQLFADAPVQTMMPQMPGQIPAQMPGQMMPPPMMAPPPPVVPVSNNNMGMLAPPPPVPQPAPFPATIPPPPLPPMTGGQPPLPPAMGIPPPPRMMQPNAWAPPGMPAPPPRPPPTNWRPPPVPFPPTPYARPYQPDGYQY
Protein: Interferon gamma receptor 2 (D4A109)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Interferon gamma
- Interferon gamma receptor 1
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase
- Interferon alpha/beta receptor 1
- Interferon alpha/beta receptor 2
- Tyrosine-protein kinase
- Tyrosine-protein kinase JAK3
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- phosphatidylinositol-4,5-bisphosphate 3-kinase
Sequence:
MRPPPLWLPLLLLCGLGAAVSSPDSLSQLAAPRKLKLHLYNDEQMLSWEPSPSSNDTRPVVYQVEYSYVDGSWHRLREPNCTDIAETKCDFTGGGRLKVFPYSYTVFLRVRARLGKHTSHWVKLDPFQHYENVTVGPPKNISVTPGKGSLVIHFSPPFDVVQEASFQYFVHYWEKTETQKVKGPYKSNSIVLDDLKPFRVYCLQTKAQLILKNRNIGPHGLLSNVSCHETTADASTSLQQVILILFGIFMLLLALTGACFILFLRYQSRVKYWFQAPPDIPEQIKEYLKDPDQLILEALDKDGSPKDEAWDSVSIISSPEKEQDDVLQIP
Protein: Mms22p (A0A1D8PRP3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
Sequence:
MSNTEYISDSEDDSLRGELLVDKNKFTNILSTLSPSKQELTRQRLETLTNISYVNIENSTCSPRLGHNQNSETRNTINNLIEDSDDDSDSNPIDLIKNLPRRSANEIEQREHSTSQHQSQDNAITQNIVGNTVVPEDQENENHLQSYLNTTNSYVTWSGRSLRKRNFASTHPYLADQAHYLGLSDIDYLNEIYEENDHNLEKVVKYLNYNYERLKKRYPKDEKFRSKNFYTIISRQSHLASEKELQEEQRNGDSGSLPNIDEEFEDEDEEGNKEFTIDPLDDLNSQTYETDESSHEPDDFLQPVKHHRLVIPDDDDEDDNFDTNSNFYSRNVANEESGSGSDSDSSKSDVYVRVGGRFRKERNALKGVLPESAKRLSIYQPKSKGPSSRHLQKPHPVSEHRKGIALRKRTKRKISERDDFTGFVDDTITYDTNNELYHELYDQPIVIEEPTPALNYPSFESVTNFSESSASEDEGEQMNYESDLDIFDVGPPQADITGVDEETGKLDENGDLDEPSDYEVREGDYINHMLATAPKRKTTAPKRQSASATTMGTSGNRTYKSQNRSIDGMLSRPKKAHSYNTKRDVRRSDSSTVSVINRSTPNSRRQRKPRTARAASDESYSRLPVKRITSLRDQNTHKTTRPTRKSKKRKDNLQLTTLDNCMKGNPKDLFTDNYLFSRSPILSTTIVEAASVTRFVKESYKNVNPSAPQMAPSIILGSQPIFEFGCILNDIVLDKITALGDGKFYQIHKDSVTIEFLGETVILTLIDLESSKFRYEKLLIHLARLSKNSDLSNESLIQTVYTTVKGILEWNLILQECPTERIWKLIHLAVSNIRDSPYLTASTMKFILPYFILVEYTMSMITKLNNKPSSFDSNPLGIRYWQLFFETFSGDLFEKSNFEAGAKTKEAESYFILCRILEESGVWWTTIIKALQVYEAFDLSLLLESVFCLCVFARKGFSWEPLQLVYQKAILEETLGVEFYYRYLEIVYFMNQRNNWPLPETVVLQIYSSITRMKFANFIDEIGMPDLIGKVSNRFDIPDDSFFERFMQLLYWYISGLSEPSKVKKLVTKLFTFSKFQYVNDQSHHVMFINRLNFILLLASVCKVDLKTQLLNLLEGIENAKDAKLIKLASQGVCVLTEIAIQRDTKLPIEGISIVIQCCINGYYNVHGILKVWKNFLISLKDLFRDPLSRLSHSLQLLNISKSIDINNVPDKIIIDICHVLSHITSSMINVKDMVIQKHIKTIKSFNEFVLSLLHRQMGRLPLPSVIQENRVCDLIEILLSIWVQCAFVLDESWDRLILQTYAYTGNQQSREQFALYFYSKILQFNNLKGCKELVTRQVLRDLVCFNPSKYLCSILQKLQKEKWGTFNFGKTNGITLSMITNSRYVVVTNILQNLASDSSIISMYEYQLYVKDILRTLDIEFEKYYSSLRYKTFCVNVIKDIQKYCEPAIINESLLTNLASKLGISENELSHLKIQKLPLKEKLKAFVGEFLNAVYFGGDYIKILEKFTFEEGVELIYHLVSVLLQEMQANSDFITWKVIYLLLKFFDENLRLFKFKFVNFQFKRFLKQLVELPKVRQRSSSTADQYCRICCLLCITSILRYCKIIFEGYTDLNEIECYWVLFSNAVHSYNADKSKFSEYVYSSFRMQDLLNDFRFPKDPNPQDDISQESLQVAHRVLVSEIDLIDTTSGEVPDTCILDYDYNF
Protein: Putative envelope-preserving system protein Rv2742c (O33285)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in preservation of envelope integrity and tolerance to surface stress. Reverses the inhibitory effect of PspA on ClgR activity. Facilitates intracellular growth of M.tuberculosis.
Interaction partners:
- Putative envelope-preserving system protein Rv2743c
- Transcriptional regulator ClgR
- Serine protease PepD
- PspA protein
Sequence:
MLVDELGVKIVHAQHVPAPYLVQRMREIHERDENRQRHAQVDVQRRRDQPERGQHQHRRNRDADHHPDGRTLAGQIVAHPVSHRVRQPRPVAIADVLPRVGPRADCVVAHSLQGSPRRRERRRGQTAHQRLGRRSGNAIACPLYLENAAGPEPDTKRAEGRRFGAFGGGDLRWMADRVPRQGSGRRGLGSRSGAGVPQGADARGWRHTADGVPRVGQPAIRRGVPGFWCWLDHVLTGFGGRNAICAIEDGVEPRVAWWALCTDFDVPRSMGRRTPGG
Protein: Interleukin-6 (IL-6) (P20607)
Organism: Rattus norvegicus (Rat)
Function: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Subcellular location: Secreted {ECO:0000269|PubMed:23955712}.
Interaction partners:
- Interleukin-6 receptor subunit alpha
- Interleukin-6 receptor subunit beta
- Interleukin-2
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase
- Transcription factor Jun
- Nuclear factor NF-kappa-B p105 subunit
- Interleukin-3
- Interleukin-1 beta
- Signal transducer and activator of transcription 3
Sequence:
MKFLSARDFQPVAFLGLMLLTATAFPTSQVRRGDFTEDTTHNRPVYTTSQVGGLITYVLREILEMRKELCNGNSDCMNSDDALSENNLKLPEIQRNDGCFQTGYNQEICLLKICSGLLEFRFYLEFVKNNLQDNKKDKARVIQSNTETLVHIFKQEIKDSYKIVLPTPTSNALLMEKLESQKEWLRTKTIQLILKALEEFLKVTMRSTRQT
Protein: CNH domain-containing protein (A0A1D8PGN0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}.
Interaction partners:
- E3 ubiquitin-protein ligase PEP5
- Probable vacuolar protein sorting-associated protein 16 homolog
- Vacuolar protein sorting-associated protein 41
- Tethering complex ATP-binding subunit
- CORVET complex membrane-binding subunit
- CCZ1/INTU/HSP4 first Longin domain-containing protein
- CORVET complex subunit
- Synaptobrevin homolog YKT6
- V-SNARE protein
- Vam7p
Sequence:
MVMNIDVIEPLDRIRISSNEIKNNKISAIYKHSVDQANEQQQLFVGLTNGDLLIYNAVKDTFLEESGQVSSADTRTISVSSAISISTHSSYQDIKRLFRGHENRSYKLANMFSNITKDGSSINKIESLPISPTKLIILITTLNSLEIFEIVGNHINQIYHVPDSKNSLSFYVLYNDRRLFFVGTKKKLTIFQIINKSRNIFQFNKLKEVVMKDKIRSIDKFDEDSIIIGLVNNYVICEFADFGVSSLAIEKNDNMLSQGTSFSYFGLSSSTPVMWTIQISDDLFLLVKDTQIVKIDRRNGPSMILSSIKLSGIPIEVLFIYPIYLFVVYPKKIEIVDVTSGDLIQKLGHSINSGHSSIILTNSVISIASGADILQFNILPFQAQIDQFLSISGKGTLGNIKDPRNDLKYMGIEKAITLVSNIDDANSLFNDAKNKLMKLRYLYSLKATLLFESYSKYHEALVDISSEWLVSFADVLNLFPAFINGQLRSKDVTSDGNENKKNSSLNVIKRITVEELELNNYSESEYDTDNTTKKGMALKQPHGQSVKAQNIRKFIKAVNNLIIYLTDQRRILSTFMDKDVLTWKNIEINPSDIYPEFDGNLETVATVIDTSLFLCYFYCKPMLLGPLLRLPNNYCDSKIVNECLLSNIHNHVQQRNSKQPNFIKELLDFYYTRSLHEEALEMLYKLAHDEGTIEHSNEDDNKFDDFIKGPDLTIQYLRKLTDDNLYLVLKYSSWVIDQDKNAARPIFMNDSYECESYDNTKVLQFLCKKDQDLGIMYLEWLLFASDISESLKKSKLYSQLETKLCLLYLKQLKSGKHQNDYYNKLLEILKTSQTFEPWSILKEMPTTQDKFLRLTIYIYKKLGEHEKSIDVLFNQLNDLDAAMEYCLEIYNRQQSSSLGSSLFYKLLEDLLMNYHENCELIVRLLSEHGAKIPILKTLSVLPRSFPMHKLKTFFTIEIKNTDEQVKDSHLVSQLYKVGSTNLQYKVMTLQNEGYKIGSSKQPCAICNKRLGYSVFTITKDHEVVHYGCAQSRKK
Protein: AAA-ATPase At3g28580 (EC 3.6.1.-) (Q9LJJ7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Copper transport protein family
- Heavy metal-associated isoprenylated plant protein 2
- Heavy metal-associated isoprenylated plant protein 31
- Stress up-regulated Nod 19 protein
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein
- BON1-associated protein 1
- Chromophore lyase CRL, chloroplastic
- Protein PSY1
- AT5G51180 protein
Sequence:
MAMMGQLWTNTGSALATLMFVYTIFKQFFPLFGPQLEPFLYRLFGRFYPYIQITFHEYSGEHFKRSEAYLGIQSYLSKDSSARAKKLKANTTKGSKSIVLSMDDKEEITDDFEGIRVWWQSKKEGATRQSFSFYPEANEKRYYMLRFHRRDREVIIERYLEHVMREGKTIEQKNRERKLYSNTPGQSHGNNSKWSHVTFEHPATFDTLAMEENKKEEIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTVKDNTHLRRLLIETSAKSIIVIEDIDCSLNLTGQRKKKEEEEEDGDDKNTIEKKMMMKNEGENKESKVTLSGLLNFIDGLWSACGGERIIVFTTNFVDKLDPALIRKGRMDKHIEMSYCCFEAFKVLAKNYLDVEESEMFEEIKRLLEVEEIKMTPADVGENLLPKSEKEGGETCLKRLIEALKEEKEEAKKKVEEEEEEKQRKKEKVKEIEAEKEKKKKIEEEN
Protein: Apolipoprotein A-II (Zgc:193613) (B3DFP9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Apolipoprotein A-IV b, tandem duplicate 1.
- Apolipoprotein A-Ib
- Apolipoprotein Bb, tandem duplicate 1
- Fibrinogen alpha chain
- Serotransferrin
- Apolipoprotein A-Ia
- Fgg protein
Sequence:
MKLTFALILALQVSVCVWAQEWPVPDKELVDKYDGLRTVFIKRLVNAWEKIKTAVEPALEGSPTAGSLKDVVEELKKSPRVESFIKIAGGLASELEPVVDKARLNALGVYGHYFRPYVGAYLDSAINNVKPVLDTVLPQGN
Protein: Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 110 kDa subunit) (eIF3 p110) (Translation initiation factor eIF3, p110 subunit) (O74760)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Subcellular location: Cytoplasm.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit F
- Eukaryotic translation initiation factor 3 subunit G
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit M
- Probable eukaryotic translation initiation factor 3 subunit J
- Probable eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 3 subunit H
Sequence:
MAPPQGKPENVLRLADELIALDQHSSALQSLHETIVLKRSRNAQGFSLEPIMMRFIELCVHLRKGKIAKEGLYTYKNAVQNTSVTAIENVVKHFIELANKRVQEAQEKADKISVEYVDDLEATETPESIMMSLVSGDLSKSRTDRALVTPWLKFLWDAYRTVLDILRNNARLEVMYQLIANSAFQFCLKYQRKTEFRRLCELLRSHLGNASKFSNAPHSINLNDAETMQRHLDMRFSQLNVAVELELWQEAFRSIEDIHSLLTFSKRAPAAVMLGNYYRKLIKIFLVCDNYLLHAAAWNRYFTFTNVQKPATANFVILSALSIPIIDANKLSGPSIEAEDAKSKNARLALLLNLSKTPTRETLIKDAISRGVLSFCDQAIRDLYQILEVEFHPLSICKKLQPIIKRLAESNDTAQYIRPLQQVILTRLFQQLSQVYDSISLKYVMDLATFEEPYDFNPGQIEKFIMNGNKKGAFSIRLNHIENSISFSSDLFSNPIKSSDSVSLQSTPSELITSQLTRIAKSLSSVLMRFDTDFCLLRKQQAEAAYERAQAGVEQERKAVIAQRSLLELRRGQADTLATQREAELAAQRALKQKQESEAESLRVQEEINKRNAERIRREKEAIRINEAKKLAEELKAKGGLEVNAEDLEHLDADKLRAMQIEQVEKQNKSMNERLRVIGKRIDHLERAYRREAIPLWEEDAKQQAEHDREIFYEREKQRKEVQERKHEQAIKDKKAFAQFASYIHAYKQNIDDERDKAYQEAYAKAKNVIDAERERQRKEIFEQKLAEAIREAEEEAARAAEEEANRELHEQEEAQKRAIEERTRAAREAKEREQREMAEKLERQRRIQQERDEEISRKLAEKAAARRANIGASSPSPGAWRRGGASAGGVSRDSPRYSRGGYSRGSVPPRETLAPSKGAYVPPSRRNQQQQ
Protein: Forkhead box protein F1-B (FoxF1-B) (FoxF1b) (Fork head domain-related protein 13') (xFD-13') (Q9W707)
Organism: Xenopus laevis (African clawed frog)
Function: Probable transcription factor. Required for smooth muscle (visceral mesoderm) differentiation during gut development. Also required for normal proliferation of the lateral plate mesoderm. Acts as a downstream mediator of bmp4-signaling.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Interaction partners:
Sequence:
MTAEIQQPPSQPPAQSSPMSAATDKHGGQPSAMESASCATKTKKTNAGIRRPEKPPYSYIALIVMAIQSSPTKRLTLSEIYQFLQSRFPFFRGSYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYSMMNGLGFNHIPDTYSFQGASGTISCPPNSLSLDSGIGMMNGHLPSNVDGMGLSGHSVSHLTANGAHSYMGSCTGASGGDYSHHDSGSPLLGGGVMDPHSVYSSPASAWAPSASTPYIKQQPLSPCNTAANPLSSSLSSHSLDQSYLHQNSHNTASELQGIPRYHSQSPSMNDRKEFVFSFNAMASSSMHSGSGSYYHQQVGYQDIKPCVM
Protein: Tryptophan permease (Tryptophan amino acid transporter) (P38967)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for high-affinity tryptophan transport. Also transports cysteine, phenyalanine and tyrosine.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Uracil permease
- Ubiquitin ligase-binding protein BUL1
- N-
- High-affinity methionine permease
- E3 ubiquitin-protein ligase RSP5
- Plasma membrane ATPase 1
- Vacuolar amino acid transporter 5
- Nitrogen permease reactivator protein
- Protein SUR7
Sequence:
MTEDFISSVKRSNEELKERKSNFGFVEYKSKQLTSSSSHNSNSSHHDDDNQHGKRNIFQRCVDSFKSPLDGSFDTSNLKRTLKPRHLIMIAIGGSIGTGLFVGSGKAIAEGGPLGVVIGWAIAGSQIIGTIHGLGEITVRFPVVGAFANYGTRFLDPSISFVVSTIYVLQWFFVLPLEIIAAAMTVQYWNSSIDPVIWVAIFYAVIVSINLFGVRGFGEAEFAFSTIKAITVCGFIILCVVLICGGGPDHEFIGAKYWHDPGCLANGFPGVLSVLVVASYSLGGIEMTCLASGETDPKGLPSAIKQVFWRILFFFLISLTLVGFLVPYTNQNLLGGSSVDNSPFVIAIKLHHIKALPSIVNAVILISVLSVGNSCIFASSRTLCSMAHQGLIPWWFGYIDRAGRPLVGIMANSLFGLLAFLVKSGSMSEVFNWLMAIAGLATCIVWLSINLSHIRFRLAMKAQGKSLDELEFVSAVGIWGSAYSALINCLILIAQFYCSLWPIGGWTSGKERAKIFFQNYLCALIMLFIFIVHKIYYKCQTGKWWGVKALKDIDLETDRKDIDIEIVKQEIAEKKMYLDSRPWYVRQFHFWC