wanglab/gogpt-training-data huggingface dataset:
Protein: HIC1 protein (Hypermethylated in cancer 1) (Hypermethylated in cancer 1 protein isoform X1) (Q70ZY9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Fibroblast growth factor-binding protein 1b.
Sequence:
MLDAMEVPSHARHLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSLYLKSLVVHDNLINLDHEMVSPGVFRVILDYIYTGRLSECDPTSPNEPNIGAVLAAASYLQLLDLVTLCKKKLKKNRKYHLSHNPTFLSYKLSLSGVGGGPFPISTPVIHPCHTVVTTPRPTTLEDLPSIPLPPHAGEIYAPAPIKGPPPYPPTKASLSPQSSLCLPPNERNCSSVYGLDLSKKSPNSQSQLSSGNPHLISSLHPDEEPEGELDQSTSPMLSPNDGSRKMDTGHHMGSLTPHPFPLPNHPLAPNLPHLHRSQGQEQYPCPPSPEPIEDTRDQRRDASNIYRWVKNEPSNPEDEDEDDEEDDSGGMGEQDKERHHQHMNHHKSNEEKLNTNERGYDRGTCDDGEDENGTGSEETGSSEGRPSPPVPGGRYHMPYEPESFGDNLYVCIPCDKGFPSSEQLNAHVETHTEEELNNGSEMDSSNNSNSKPTTVRAPTSLNSSSGLHSPYHDGKLAQNLHSIGLGEIIRPYRCSSCDKSYKDPATLRQHEKTHWLTRPYPCSICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHSSGAAGGGLTPDGKLKIDFSEGIYPLSKYTAEHLGLKQEKTSDLLAASQHLLADAKAMESLYPLSKLAVDQLGLAHKMDILNSSLPPTSQQLSAESRTIDRYSPS
Protein: N-alpha-acetyltransferase 50 (EC 2.3.1.258) (N-epsilon-acetyltransferase 50) (NatE catalytic subunit) (E7EQ69)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKGRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGELAKLAYFNDIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEKDGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVLQKNLKVPSGQNADVQKTDN
Protein: PTS system glucose-specific EIIA component (EIIA-Glc) (EIII-Glc) (Glucose-specific phosphotransferase enzyme IIA component) (P69783)
Organism: Escherichia coli (strain K12)
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. The non-phosphorylated EIII-Glc is an inhibitor for uptake of certain sugars such as maltose, melibiose, lactose, and glycerol. Phosphorylated EIII-Glc, however, may be an activator for adenylate cyclase. It is an important regulatory protein for cell metabolism.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Phosphocarrier protein HPr
- PTS system glucose-specific EIICB component
- Phosphoenolpyruvate-protein phosphotransferase
- Glycerol kinase
- PTS system maltose-specific EIICB component
- PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component
- PTS system N-acetylmuramic acid-specific EIIBC component
- PTS system trehalose-specific EIIBC component
- Multiphosphoryl transfer protein 1
- Maltose/maltodextrin transport system permease protein MalF
Sequence:
MGLFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVGETPVIRIKK
Protein: Necdin-like protein isoform 3 (A0A0S2Z3Y6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSEQSKDLSDPNFAAEAPNSEVHSSPGVSEGVPPSATLAEPQSPPLGPTAAPQAAPPPQAPNDEGDPKALQQAAEEGRAHQASCS
Protein: Large ribosomal subunit protein uL4z (60S ribosomal protein L4-1) (L1) (Q9SF40)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Large ribosomal subunit protein eL8z
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS24y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL24z
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL6x
- Large ribosomal subunit protein eL32z
Sequence:
MAAAAARPLVTIQTLDGDMSTDQSSTVVLPDVMTAPVRPDIVNFVHAQISNNSRQPYAVSKKAGHQTSAESWGTGRAVSRIPRVPGGGTHRAGQAAFGNMCRGGRMFAPTKIWRRWHRRVNVNMKRHAIVSAIAATAVPALVMARGHKIENVPEMPLVVSDSAEAVEKTSAAIKVLKQIGAYDDAEKAKNSIGIRPGKGKMRNRRYISRKGPLVVYGTEGSKIVKAFRNLPGVELCHVERLNLLKLAPGGHLGRFVIWTKSAFEKLESIYGSFEKPSEKKKGYVLPRAKMVNADLARIINSDEIQSVVNPIKKDAKRAVLKKNPLKNLNVMLKLNPYAKTAKRMSLLAEAQRVKAKKEKLAKKRKTVTKEEALAIKAAGKSWYKTMISDSDYTEFDNFTKWLGASQ
Protein: E3 ubiquitin-protein ligase SIS3 (EC 2.3.2.27) (Protein SUGAR INSENSITIVE 3) (RING-type E3 ubiquitin transferase SIS3) (Q8GYT9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin protein ligase that acts as positive regulator of sugar signaling during early seedling development. Possesses E3 ligase activity in vitro.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- E3 ubiquitin-protein ligase ATL9
- At5g63780
- Peroxisome biogenesis factor 10
- E3 ubiquitin-protein ligase AIRP1
- F-box/kelch-repeat protein SKIP6
- E3 ubiquitin-protein ligase XBAT32
- Peroxisome biogenesis protein 2
- Brassinosteroid-responsive RING protein 1
Sequence:
MAMRGVDFKWYDGFFLSMLATSVIIVAVNWNRYRACEYPLHIWIVVDYTTVFIFRVFMFVDNGLASGLGLDFGSQQRNAMFCGRVVVLSVLSLLLYPFLWAWTVIGTQWFTKSKTCLPEEGQKWGFLIWLMFSYCGLLCIAFICVGKWLTRRQVHLLRAQQGIPISEFGILVDMIRVPDWAFEAAGQEMRGISQDAATYHPGLYLTPAQTEAVEALIQELPKFRLKAVPDDCGECLICLEEFHIGHEVRGLPCAHNFHVECIDQWLRLNVKCPRCRCSVFPDLDLSALSNLQSSGTEQHSQVNTETSEARYIRSQPQSESYFLRVQSLIHPVHTDTALETAENGGVPPVLTDLSPSRR
Protein: Eukaryotic translation initiation factor 3 subunit G (K7ENA8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSPEPELLPGAPLPPPKEVINGNIKTVTEYKIDEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTELEPVQATQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAI
Protein: RE32936p (SET and MYND domain containing, class 4, member 2) (Q9VTX2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein-lysine N-trimethyltransferase SMYD5
- AT24727p
- SET and MYND domain containing, arthropod-specific, member 6
- SET domain-containing protein SmydA-8, isoform A
- GH11294p
- SET and MYND domain containing, arthropod-specific, member 2
- SET and MYND domain containing, arthropod-specific, member 4, isoform A
Sequence:
MEFDATYHEICSAQTVQSERRGFFNEFCVDVRDACGDKWLRNYFGKLKSNAARVLSIFSDREVCDPVLGVLEHVQPVFKQKDALFSAQRRAQADKLYLMSGSGDGEESRELLQQALMAANLAVMRAPDRNADPVLDEGLTLALAYRSRASILIRLGEGEAALNDLKLAINFGLELKSSVDYYLKMAKAYAVMGEPARAEISLKIAEKMPGCDATHIALCRKELSSVKPKPKEATSEQVPQLAHGESAELVGASKVVRLVETKDKGRFVVANEGLRTGDVLLFEEPVAACLEPSYFGTHCHHCFKRLHTPVSCLHCSGIAFCSAQCMGEACSSYHRFECEYMDLMIGSGMSILCFIALRIFTQAPSLEQGLATANLLFEHLCSHEEDRQPDDYLRRALMSGFLLRILQKSLYFGRRKTEGVNPTAVELQVATALLGLLQVLQYNAHQIYQTQVTEEHRFDGSKTVYLAAGLYGTGSYFNHECWPSTACHFVGKKLVLTATRPHRANELVAVNYGPIFIKNNLKERQRSLRGRYSFSCSCMACQENWPLLQKLDKQVRFWCTSANCSNLLKFPKDLAKDVRCPRCRKNISLKESVAKMIKIEELYREAARAMEAQKTVEAIELFKESLDMFFQVAALPHKDTIVAQQSLHKCLSDTGTTFKKEGK
Protein: Ribosome biogenesis protein NSA2 (NOP7-associated protein 2) (P40078)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles. Under normal, rapid growth conditions, high levels of NSA2 would allow the progression of pre-60S particles through the ITS2 processing.
Subcellular location: Nucleus, nucleolus {ECO:0000305}.
Interaction partners:
- Ribosome biogenesis protein ERB1
- Large ribosomal subunit protein uL29A
- Ribosome assembly factor MRT4
- Probable metalloprotease ARX1
- Ribosome biogenesis protein NSA1
- Nucleolar GTP-binding protein 1
- Ribosome biogenesis protein RLP24
- Ribosome biogenesis protein YTM1
- 60S ribosome subunit biogenesis protein NIP7
- Ribosome production factor 1
Sequence:
MPQNDYIERHIKQHGKRLDHEERKRKREARESHKISERAQKLTGWKGKQFAKKRYAEKVSMRKKIKAHEQSKVKGSSKPLDTDGDALPTYLLDREQNNTAKAISSSIKQKRLEKADKFSVPLPKVRGISEEEMFKVIKTGKSRSKSWKRMITKHTFVGEGFTRRPVKMERIIRPSALRQKKANVTHPELGVTVFLPILAVKKNPQSPMYTQLGVLTKGTIIEVNVSELGMVTAGGKVVWGKYAQVTNEPDRDGCVNAVLLV
Protein: Gem-associated protein 2 (Q86DC9)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MALKIEKFSPMRIDRLNSPEEEEWHEILLEKCLPEFQDIAGNFLNHTGTPPALRMVFSIPKRHLSQLIEYLVDWSIEEGLNRPIREWIYSLLAVIDLPLVQDVVSALRRLVKECRFIDFSENYRFFRGKY
Protein: E2F transcription factor-like E2FF (DP-E2F-like protein 3) (E2F-like repressor E2L2) (Q8RWL0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:11867638}. Cytoplasm {ECO:0000269|PubMed:11867638}.
Interaction partners:
- Transcription factor-like protein DPA
- Transcription factor-like protein DPB
- Retinoblastoma-related protein 1
- Protein FIZZY-RELATED 1
- Chromosome transmission fidelity protein 18 homolog
- Cyclin-dependent protein kinase inhibitor SMR6
Sequence:
MSSAIVVSQDAESLGLQIYSRKEKSLGVLVSNFLRLYNRDDVDLIGLDDAAGQLGVERRRIYDVVNILESIGIVARRGKNQYSWKGFGEIPRSLDELKEEGMRERLGYSSSNNSDKVSNGCEREEPLTLTPDDQENSSSSKMDQKKEKSLWLLAQNFVKMFLCSDDDLITLDSAAKALLSDSPDSVHMRTKVRRLYDIANVFASMNLIEKTHIPVTRKPAYRWLGSKSIAERGLSLFNSGEPKRVFGTEITNLRAKRNKTYCSSIRKQIGYKKHDEENTEQESKPAASKYVFGPFSPIGASKTNNDKVGKGRLLEIEALASTYQPQYCNQEITGLLGHFTEAWKKWYAEVDRNK
Protein: Centromeric protein-C, isoform B (A0A0B4LGX0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSKPQNNDTLELDDILSQPVKDKERFAAFMMRKLAENKPAQNDNLFGNFKLDFDLDFEVPLIKKSQAKPKSKLPEVQPLGELVSKNSAATEKVNEPPVDQAPNENVPPRRSPTLSPNNRRSMRRSGNVPGSDKLRRHAIRRRSRSCGRQLLPEFEETVNLTRSISSPVNFLPEISSTPCTEKQKEEVAKNTTRVETDKPAEKPMELSQEPEPENPLQTKVTSPARNPILAAEIEQICKERQSSFHKNVLQLDYSGRAPYSRPPTPSSPSVAGLRRTYTMEKGPAPGQLLLSPSHRYDTPSKMPVVKAKRFNQELMVPDTPERQSHDPAWQSEPQPEFVVPETQPQDLGELVQTLSRSAISPIVVINTSNSNRSVRRDAVAMKSVPTSPVTALSSPPIAPSPRRSAAASPQKSIAQLPRVEENMDAIMTDDESDEHPSTVPLNLAPSGGNTTRQRRLRSSNRARATIESQESSMRLLNLHKSVNAKKSKPRKTAIPLNKAPSAPINGEQFARELTRMSNYEILDLRKRNSLNEIYPLNGHRNHRSEKLILEEEIQRELLRRNLMDEAEGLPKQQSSDDSNEDYIPVPPKTQSLRTKSNDRSQGRGRPRSTRRDLPMTLETRRKSSKDGKRCLYTKGSSDHEDNDSLSPVKLPRLSKSIQIVPPPPVSLRYSQSLQNLPCSGKFDFDNVVMAAPPDFHDSVNSDAIEIAPPPPEYVVNTRGRSTSGRKSNKNDLVLPPPGYEGGQEEEHDERPSQPRCTAKELQQSTQNGRRAMENELVPPPIEYVEEENRNNEQSRRSTKNGNLVDRNTHNAVEYCEPPEPPEYDDSDHGQASILRRSGKKLQHSKQSVQKSNKEQIIAPSYENNEDYDSDEEPIYNEEYGKEESQNKNVTRRKSDKDEMASHTLECIEGPDPNWNSSCNKQNRNHQNASKSKENDKLANRSSKSQKLSNPRQNAVGTEKSVALSNRGEECTEKSSDVMESLRVNTPTPPIDQNSDDVPSRNPSPSRTLLSDDVPSTSRAALEFLQRSQNMSKSRPPDESSADVVFKKPLAPAPRAKSKKGKSEVDKLKLAKMPVEAEELNTTGIRRSKRGQVPLQMSWCHTMDPSKFNFMSGFIEPRSKNSKTKKGNLSKAKKASATKPKPTVEKNLPDNRGPLCSSTPRISEKLPGAIPHSESLGLSTLTWEETEVQAEAEKVPKKRGRPKKAVGGVQTDTEAEPEPEPEPMISSVAPLTSDQEEPDVPDEQAPYTEAALGPVVFSTPLRDEQEEASTKLMQWLRGVGDAPPSASMSDENASVSSANELIFCQVDGIDYAFYNTKEKAMLGYMRFKPYQKRSMKQAKVHPLKLLVQFGEFNVETLAVGEEKEVHSVLRVGDMIEIDRGTRYSIQNAIDKVSVLMCIRS
Protein: Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (Heat shock 70 kDa protein 9) (D6RCD7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKVQGLKWILILT
Protein: Amyloid-beta A4 precursor protein-binding family A member 3 (Adapter protein X11gamma) (Neuron-specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (O70248)
Organism: Rattus norvegicus (Rat)
Function: May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000250}.
Interaction partners:
- Peripheral plasma membrane protein CASK
- Peripheral plasma membrane protein CASK
- Amyloid-beta precursor protein
- MCF.2 cell line derived transforming sequence
Sequence:
MEFLPEPQHPPGPPTMDLEEPKGPEVPSEDHPSNTQWALGPRGPDTLSEMELDTSSVRALVQQLEALPSDLGGQFPDGAPCPLHIATGQGLATQENLDAGGLLSAEAGGDNLLGLLRCEASLPAQSVPPDPAQAAPRLLQPPEDPGGDPGWMEGTEPADNRSSSSSPELWLETAPLVTHRDPPVGTQSQETLASCPAVSEVPGPCGQEELMDGVLFGAKYLGSTQLLSERNPPPSTRMGQAQEAMDRVKAPEGETQPMTEVDIFISTKRVKVLAADSQDALMDHALQTISYIADIGPVLVLMARRRLAKRTTSQDRQRQLYKMLCHVFHSEDAQLIAQAIGQAFSIAYSQFLQENRIDPSQVGMQPSASASHPHNGDLDHFCNSQNCREVCIQKRPGEGLGVALVESGWGSLLPTAVIANLLHGGPAERCGALSIGDRVTAINGTSLVGLSLAACQAAVREVRRHSSVTLSIIHCPPVTTAVIHRPHVREQLGFCVENGIICSLLRGSAAERGGVRVGHRIIEVNGQSVVAMPHARIIQLLTETREIHIKTMPAATYRLLTGQEQPVYL
Protein: NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Q60778)
Organism: Mus musculus (Mouse)
Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Subcellular location: Cytoplasm. Nucleus.
Interaction partners:
- NF-kappa-B inhibitor alpha
- Transcription factor p65
- Proto-oncogene c-Rel
- Nuclear factor NF-kappa-B p105 subunit
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- NF-kappa-B essential modulator
- NF-kappa-B inhibitor epsilon
- Transcription factor RelB
- Nuclear factor NF-kappa-B p100 subunit
Sequence:
MAGVACLGKTADADEWCDSGLGSLGPDAAAPGGPGLGAELGPELSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYLDLQNDLGQTALHLAAILGEASTVEKLYAAGAGVLVAERGGHTALHLACRVRAHTCACVLLQPRPSHPRDASDTYLTQSQDCTPDTSHAPAAVDSQPNPENEEEPRDEDWRLQLEAENYDGHTPLHVAVIHKDAEMVRLLRDAGADLNKPEPTCGRTPLHLAVEAQAASVLELLLKAGADPTARMYGGRTPLGSALLRPNPILARLLRAHGAPEPEDEDDKLSPCSSSGSDSDSDNRDEGDEYDDIVVHSGRSQNRQPPSPASKPLPDDPNPA
Protein: Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) (P45479)
Organism: Rattus norvegicus (Rat)
Function: Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
Subcellular location: Lysosome {ECO:0000250|UniProtKB:P45478}. Secreted {ECO:0000269|PubMed:7916016}.
Interaction partners:
- Lysosomal thioesterase PPT2
- Enoyl-[acyl-carrier-protein] reductase, mitochondrial
- Battenin
- CLN6, transmembrane ER protein
- Protein CLN8
- Tripeptidyl-peptidase 1
- Long-chain-fatty-acid--CoA ligase 5
- Long-chain-fatty-acid--CoA ligase ACSBG2
- Long-chain-fatty-acid--CoA ligase 4
- Fatty acid CoA ligase Acsl3
Sequence:
MASPGYRRLLAAALLPWCCAAWALGHLDPPSPPPLVIWHGMGDSCCNPMSMGSIKKMVEKEIPGIYVLSLEIGKNMVEDVENSFFLNVNLQVGMACQILEKDPKLQHGYNAIGFSQGGQFLRAVAQRCPTPPMMTLISVGGQHQGVFGLPRCPGESSHICDFIRKSLNAGAYSKVVQERLVQAQYWHDPIKEEVYRNCSIFLADINQERHINESYKENLMALKKFVMVKFFNDSIVDPVDSEWFGFYRSGQAKETIPLQETTLYTEDRLGLKKMDKAGKLVFLAKEGDHLQISKEWFTAHIIPFLK
Protein: Lymphocyte antigen 6K (Ly-6K) (Q9CWP4)
Organism: Mus musculus (Mouse)
Function: Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. May play a role in cell growth (By similarity).
Subcellular location: Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:27005865}; Lipid-anchor, GPI-anchor {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:27005865}. Membrane raft {ECO:0000269|PubMed:18503752}.
Interaction partners:
- Testis-expressed protein 101
- Lymphocyte antigen 6H
- Secreted Ly-6/uPAR-related protein 1
- Ly-6/neurotoxin-like protein 1
- Ly6/PLAUR domain-containing protein 2
- Ly6/PLAUR domain-containing protein 4
Sequence:
MAFLVALLVVLGLQLVQSNALTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVSPPSTNPPSEPKEFLIEKPMPFLFYKCCQWDSCNGEGPPTDQLLKEQPGKASGRRHRYIELLLTGFMVLTANGLSALCLL
Protein: Semaphorin-3C (A0A1D5PZ68)
Organism: Gallus gallus (Chicken)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MAVLALHAVFGIFIYFSSVKGSSQPQARVFLTFNELQETKTSEYHRISHSPLDYRILLMDEDQDRIYVGSKDHILSLNINNISQDPLSIFWPASANKVEECKMAGKDPTHGCGNFVRVIQSYNRTHLYVCGSGAFSPVCVYVNRGRRSEEQIFKIDSKCESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPIFVDAHVIPDGTDPNDAKIYFFFKERLTDNSGSTKQIHSMIARICPNDTGGQRSLVNKWTTFLKARLVCSVMDEDGTETYFDELEDVFLLETDNPRTTLVYGIFTTSSSIFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLIPYQGRIPYPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNPIYPIHKRPLIIRIGTDYKYTKIAVDRVNAADGRYHVLFLGTDQGTVQKVVVLPTNFSASGELILEELEVFQSNSPITTMKISSKKQQLYVSSEEGVTQVPLHRCHIYGTACADCCLARDPYCAWDGNSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAETVQYGVKNNTTFLECTPKSPQASIKWLLQKDNDRRKEVKLSERIIATEQGLLIRSVQDSDRGLYHCIATENNFKQTLAKINFKVLDTEMVAYMTDKWSPWTWASSVRALQFHPKDFVGAFSHSEMQMINQYCKDSRQQGQRREEPQKMRGDYSKLKALINSRKSRNRRNQLPGS
Protein: Fanconi-associated nuclease 1 homolog (EC 3.1.4.1) (Q9Y804)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Putative MutL protein homolog 1
Sequence:
MKRFFNEACDINTPDKSGVNENKLCFPPLKVVCQAPETTVKGQVANTNKHNVYSTKNSMYLLGFEEILNTVLDCEPHIFTDDELRVIENFKALDSDERYLFVRLFMRKRNKWFRVGHLTYPDCKDVIACCKQLVLKNFFEDESLMSTEEIIEILSLDELRSLARQTKVCGKSRSEISKEIIFLSKRQSVLHCNGQQFLSFDAFGVMHKQESFLRKQLLYQCKSCVKPKKILVDLFHRINIVYFRSSIYDEQSLTSLILARLNKFSYPNYVLSRTSNVFNCRAQCLEYVEVLELSKNLVPIFENTAASDKEALEQALNSFFEIYPIWSTYLNEDIREFWVEENRKVDTRLVRFSFSFRPGAVYTYLIHKSLNILAKSRLVEVEHEILDTLLSQNIYLVGKRGHWYNRKALLEYNFKTEDTNVLRYWKTLALSTCENGIEDKYTHLRYYFSLQRRLVRLRKCLKVSNTTELKSMKLINNNPSRLFLHGERIHNGDLSNRTVWRSKTNNAITVEELALQHYQSIGWEGIHAESSILLTLFALTFWDILFEDVPGVFQSPFQSAPLDLHTDSFYISRESTIMKRLEEIRNGKAGLIIKDNYIREHQRKTFCVGLNWSYTCEMLLEIVDCINDNGLAQIFLALTQDYKNSSSGIPDLCLWNPSKKKFMFSEVKSDNDRLSEAQKFWISLLISSEVDVEVCHVSMHKKK
Protein: WD_REPEATS_REGION domain-containing protein (Q93759)
Organism: Caenorhabditis elegans
Interaction partners:
- Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1
- Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2
- DNA damage-binding protein 1
- Cullin-4
- Ras GTPase-activating protein-binding protein gtbp-1
Sequence:
MIDQSQAAPSSSTSSSHLMHHHSNNYPSYTNPSASSSNHSNMGHPNASTGQTSAVQRMDPFNQIPSELYGSASSTSIAASTRQPSSQSQPSQQFRQMPADLGASTSTMHSVAPIDIYDNYGNASTSDLRRSSVRGDPRRKEIYAYNAPFTLFSHGWSAATDPSRKFRLAVSSFIEEYSNKIHIVQLDEEAGELVHRSTFDHPYPATKIMWIPDQKGTFPDLLATSGDYLRLWRIGTDNNACIESLLNTNRTAEYCAPLTSFDWNELDMNLIGTSSIDTTCTVWQLETGQAIGTTRPTAAIDGTVRTQLIAHDKEVFDISFSRGSAQIFASVGADGSLRLFDLRRLEHSTIMYEDPQRQPLLRLAWNRNDHNYIATFGQDSKEVLILDLRLPCTPVARLRNHEATINGLSWAPHSGSHICTAGDDYQALIWDVHEMPKPINDPILAYRAQAEVNQIHWSSSFPDWISICSDNKLEILRV
Protein: Bone morphogenetic protein 10 (BMP-10) (Q4AEG6)
Organism: Rattus norvegicus (Rat)
Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P12643}.
Interaction partners:
- Activin receptor type-1-like
- Bone morphogenetic protein receptor type-2
- Activin receptor type-2A
- Endoglin.
- Activin receptor type-1
- Activin receptor type-2B
- Growth/differentiation factor 2
Sequence:
MGSLVLPLSAVFCLVARLASGSPIMGLEQSPLEEDMPFFDDIFTEQDGIDFNTLLQSMKDEFLKTLNLSDIPPQDTGRVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGIRKYPLLFNVSIPHHEEVVMAELRLYTLVQRDRLMYDGVDRKIIIFEVLESADGSEDERSMLVLVSTEIYGTNSEWETFDITDATRRWQKSGPSTHQLEIHIESRQNQAEDTGRGQLEIDMSAQNKHDPLLVVFSDDQSGDKEQKEELNELISHEQDLDLGTDGFFGGPDEEALLQMRSNMIDDSTARIRRNAKGNYCKKTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLDPISILYLDKGVVTYKFKYEGMAVSECGCR
Protein: NAC domain-containing protein 62 (ANAC062) (Protein NTM1-like 6) (Q9SCK6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Transcriptional activator involved in response to cold stress. Mediates induction of pathogenesis-related (PR) genes independently of salicylic signaling in response to cold. Binds directly to the PR gene promoters and enhances plant resistance to pathogen infection, incorporating cold signals into pathogen resistance responses. Plays a regulatory role in abscisic acid (ABA)-mediated drought-resistance response.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19947982}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353, ECO:0000269|PubMed:19947982, ECO:0000269|PubMed:20156199, ECO:0000269|PubMed:22967043}. Note=Localized primarily in plasma membrane as dormant form and, upon cold or stress, is processed into a transcriptionally active and nuclear form after a proteolytic cleavage through regulated intramembrane proteolysis (RIP). {ECO:0000269|PubMed:19947982, ECO:0000269|PubMed:20156199}.
Interaction partners:
- bZIP transcription factor 60
- bZIP transcription factor 28
- At2g39650
- Zinc finger CCCH domain-containing protein 29
- Zinc finger CCCH domain-containing protein 47
- Serine/threonine-protein kinase SRK2C
- Endoplasmic reticulum oxidoreductin-1
- Serine/threonine-protein kinase/endoribonuclease IRE1b
- DNA replication ATP-dependent helicase/nuclease JHS1
Sequence:
MNQNLHVLSMDSLPVGLRFRPTDEELIRYYLRRKINGHDDDVKAIREIDICKWEPWDLPDFSVIKTKDSEWLYFCPLDRKYPSGSRQNRATVAGYWKATGKDRKIKSGKTNIIGVKRTLVFHAGRAPRGTRTNWIIHEYRATEDDLSGTNPGQSPFVICKLFKKEELVLGEEDSKSDEVEEPAVSSPTVEVTKSEVSEVIKTEDVKRHDIAESSLVISGDSHSDACDEATTAELVDFKWYPELESLDFTLFSPLHSQVQSELGSSYNTFQPGSSNFSGNNNNSFQIQTQYGTNEVDTYISDFLDSILKSPDEDPEKHKYVLQSGFDVVAPDQIAQVCQQGSAVDMSNDVSVTGIQIKSRQAQPSGYTNDYIAQGNGPRRLRLQSNFNGINTKNPELQAIKREAEDTVGESIKKRCGKLMRSKNVTGFVFKKITSVKCSYGGLFRAAVVAVVFLMSVCSLTVDFRASAVS
Protein: Flowering-promoting factor 1 (AtFPF1) (O23624)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates the competence to flowering of apical meristems. Involved in a GA-dependent response in apical meristems during the transition to flowering.
Interaction partners:
- Alpha-crystallin domain 32.1
- B3 domain-containing transcription factor VRN1
- MADS-box protein SOC1
- Protein LEAFY
Sequence:
MSGVWVFKNGVIRLVENPNQSGSDTQNRRKVMVYLPTGEVVSSYSTLEQILQSLGWERYFGGGDTDLLQFHKRSSIDLISLPRDFTKFNSVYMYDIVVKNPNYFHVRDSH