wanglab/gogpt-training-data huggingface dataset:
Protein: Sox102F, isoform A (Sox102F, isoform C) (Sox102F, isoform D) (Q9V480)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MTDIDASAQQQQQLQNVQRLQHESCLQELHNHLSSQYGAVRFTAANPQHQNQQAVSVSSGNLMPFLPAFLQPPMPNAQQLLQLIPGHENAQSVPTHHHSHPQSEAFSTHKMALAPMWSTAAVAAAHIQAALAAAAVAAANNNKNSSHFSNNTNIVGLATRGNELLNTDSDPQMEIGETRRGGNGGSCRSRPESPTYENPPYEILSYSHNTPPESPHGRTADCSKNFSPSPTDNLSIASVSEAQDSEMDAPLNLSKPKGSPSSSPNSSSQRDHCENLTPVVSSPPLSWHQGQPHYAEIELPLLKSHGRVWNSAVACSGGSRATRVSRDSVNSCGTNSERSAALDPESLNSGQLGPVPASPSSQPLRQGNGHGHGGNHGHVHSKPHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNADKQPYYEEQSRLSKLHMEQHPDYRYRPRPKRTCIVDGKKMRISEYKVLMRNRRAEMRQLWCRTGGVSGGSGSLCADACPKGSGGSNSQVAVAAAAAVYHLQDMASSAASTAHGHDCGHTPPQQFFYPPESLSPSGFSSDEVELASQRELDD
Protein: HTH-type transcriptional regulatory protein TyrR (Q9I572)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
- Phenylalanine-4-hydroxylase
- DUF2790 domain-containing protein
- Pterin-4-alpha-carbinolamine dehydratase
- 4-hydroxyphenylpyruvate dioxygenase
- Aromatic-amino-acid aminotransferase
- Homogentisate 1,2-dioxygenase
- RNA polymerase sigma-54 factor
Sequence:
MRIKVHCQNRVGILRDILNLLVDYGINVNRGEVGGDQGNAIYLLCPNMINLQLQSLRPKLEAVPGVFGVKRVGLMPSERRHLELNALLAALDFPVLSVDMGGQIVAANRAAAQLLGVRVDEVPGIPLSRYVEDLDLPELVRANKARINGLRVKVKGDVFLADIAPLQSEHDESEALAGAVLTLHRADRVGERIYHVRKQELRGFDSIFQSSRVMAAVVREARRMAPLDAPLLIEGETGTGKELLARACHLASPRGQSPFMALNCAGLPESMAETELFGYGPGAFEGARPEGKLGLLELTAGGTLFLDGVGEMSPRLQAKLLRFLQDGCFRRVGSDEEVYLDVRVICATQVDLSELCAKGEFRQDLYHRLNVLSLHIPPLRECLDGLAPLAEHFLDQASRQIGCGLPKLSAQALERLERYHWPGNVRQLENVLFQAVSLCEGGTVKAEHIRLPDYGAPQPLGDFSLEGDLDAIVGRFEKAVLERLFREHPSSRQLGKRLGVSHTTAANKLRQHGVGQSEG
Protein: UPF0386 protein YjhX (Q2EEU2)
Organism: Escherichia coli (strain K12)
Interaction partners:
- Uncharacterized N-acetyltransferase YjhQ
Sequence:
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRAQLDNR
Protein: RNA-binding protein BRN2 (Protein BRUNO-LIKE 2) (AtBRN2) (Q8GZ26)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: RNA-binding protein involved in the regulation of flowering time. Acts as repressor of the activity of SOC1, a transcriptional activator of flowering time. Binds to the 3'-UTR of SOC1 mRNA in the cytoplasm and participates in SOC1 mRNA decay, mediated by the distal region of the SOC1 3'-UTR.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23437850}.
Interaction partners:
- At3g57000
- Uncharacterized protein At5g06590
- Arginine-specific demethylase JMJ22
- Probable aspartyl protease At4g16563
- U-box domain-containing protein 45
- Proline-rich extensin-like protein EPR1
- Aladin
- Probable CCR4-associated factor 1 homolog 5
- THO complex subunit 4B
- At1g14330/F14L17_7
Sequence:
MAEETMENEERVKLFVGQVPKHMTEIQLLTLFREFSIVNEVNIIKEKTTRAPRGCCFLTCPTREDADKVINSFHNKKTLPGASSPLQVKYADGELERLEHKLFVGMLPKNVSETEVQSLFSEYGTIKDLQILRGSLQTSKGCLFLKYESKEQAVAAMEALNGRHIMEGANVPLIVKWADTEKERQARRLLKVQSHVSRLDPQNPSMFGALPMSYVPPYNGYGYHVPGTYGYMLPPIQTQHAFHNVISPNQGNGRALQGTALTESVPPRLAPRRNFPTALGNYGYHGLQYPMAFPRGMIPPRLPLTTVSPGISNNGTSIPSSLQTEGPAGANLFIYNIPREFEDQELAATFQPFGKVLSAKVFVDKATGISKCFGFISYDSQAAAQNAINTMNGCQLSGKKLKVQLKRDNGQQQQQQQSKNPLFNGLLNS
Protein: Dihydroxyacetone kinase 2 (DHA kinase 2) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase 2) (Triokinase 2) (Triose kinase 2) (P43550)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.
Interaction partners:
- Triosephosphate isomerase
- Glycerol 2-dehydrogenase
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Fructose-bisphosphate aldolase
- Dihydroxyacetone kinase 1
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase [NAD
- S-formylglutathione hydrolase
- Glycerol-3-phosphate O-acyltransferase 2
- Glycerol-3-phosphate O-acyltransferase 1
Sequence:
MSHKQFKSDGNIVTPYLLGLARSNPGLTVIKHDRVVFRTASAPNSGNPPKVSLVSGGGSGHEPTHAGFVGEGALDAIAAGAIFASPSTKQIYSAIKAVESPKGTLIIVKNYTGDIIHFGLAAERAKAAGMKVELVAVGDDVSVGKKKGSLVGRRGLGATVLVHKIAGAAASHGLELAEVAEVAQSVVDNSVTIAASLDHCTVPGHKPEAILGENEYEIGMGIHNESGTYKSSPLPSISELVSQMLPLLLDEDEDRSYVKFEPKEDVVLMVNNMGGMSNLELGYAAEVISEQLIDKYQIVPKRTITGAFITALNGPGFGITLMNASKAGGDILKYFDYPTTASGWNQMYHSAKDWEVLAKGQVPTAPSLKTLRNEKGSGVKADYDTFAKILLAGIAKINEVEPKVTWYDTIAGDGDCGTTLVSGGEALEEAIKNHTLRLEDAALGIEDIAYMVEDSMGGTSGGLYSIYLSALAQGVRDSGDKELTAETFKKASNVALDALYKYTRARPGYRTLIDALQPFVEALKAGKGPRAAAQAAYDGAEKTRKMDALVGRASYVAKEELRKLDSEGGLPDPGAVGLAALLDGFVTAAGY
Protein: Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (P57102)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
- NK2 homeobox 5.
- GATA-binding protein 4.
- T-box transcription factor TBX5-A
- Myocyte enhancer factor 2ca
- GATA-binding protein 5
- GATA-binding protein 6
- T-box transcription factor TBX20
- Paired-like homeobox 2b
- Myosin light chain 2 Mlc2a
- Insulin gene enhancer protein isl-1
Sequence:
MSLVGGFPHHPVMHHDGYSFAAAAAASRCHEEPPYFHGWLISHPEMSPPDYTMAPSYSPEYSTGAPGLDHSHYGGVPGAGAVGMGPRTVKRRPTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDILDKDEQNGETEAFKAEFKKTDAKEERRKKEMNDVLKSSGSSNDKKTKGRTGWPQHVWALELKQ
Protein: Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) (P06744)
Organism: Homo sapiens (Human)
Function: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11437381}. Secreted {ECO:0000269|PubMed:11437381}.
Interaction partners:
- Glucose-6-phosphate 1-dehydrogenase
- Triosephosphate isomerase
- GDH/6PGL endoplasmic bifunctional protein
- Mannose-6-phosphate isomerase
- Transketolase
- ATP-dependent 6-phosphofructokinase, muscle type
- ATP-dependent 6-phosphofructokinase, liver type
- ATP-dependent 6-phosphofructokinase, platelet type
- Transketolase-like protein 2
- Glyceraldehyde-3-phosphate dehydrogenase
Sequence:
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDASTNGLINFIKQQREARVQ
Protein: Cyclic nucleotide-gated channel beta-1 (CNG channel beta-1) (240 kDa protein of rod photoreceptor CNG-channel) (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Glutamic acid-rich protein) (GARP) (Q28181)
Organism: Bos taurus (Bovine)
Function: Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Cyclic nucleotide-gated channel alpha-1
- Cyclic nucleotide-gated channel alpha-2
- Cyclic nucleotide-gated channel alpha-4
- Calmodulin
- EF-hand calcium-binding domain-containing protein 11
- CALML5 protein
- Calmodulin-like protein 4
- Cyclic nucleotide-gated channel alpha-3
- Guanine nucleotide-binding protein G
- Rhodopsin
Sequence:
MLGWVQRVLPQPPGTPQKTKQEEEGTEPEPELEPKPETAPEETELEEVSLPPEEPCVGKEVAAVTLGPQGTQETALTPPTSLQAQVSVAPEAHSSPRGWVLTWLRKGVEKVVPQPAHSSRPSQNIAAGLESPDQQAGAQILGQCGTGGSDEPSEPSRAEDPGPGPWLLRWFEQNLEKMLPQPPKISEGWRDEPTDAALGPEPPGPALEIKPMLQAQESPSLPAPGPPEPEEEPIPEPQPTIQASSLPPPQDSARLMAWILHRLEMALPQPVIRGKGGEQESDAPVTCDVQTISILPGEQEESHLILEEVDPHWEEDEHQEGSTSTSPRTSEAAPADEEKGKVVEQTPRELPRIQEEKEDEEEEKEDGEEEEEEGREKEEEEGEEKEEEEGREKEEEEGEKKEEEGREKEEEEGGEKEDEEGREKEEEEGRGKEEEEGGEKEEEEGRGKEEVEGREEEEDEEEEQDHSVLLDSYLVPQSEEDRSEESETQDQSEVGGAQAQGEVGGAQALSEESETQDQSEVGGAQDQSEVGGAQAQGEVGGAQEQDGVGGAQDQSTSHQELQEEALADSSGVPATEEHPELQVEDADADSRPLIAEENPPSPVQLPLSPAKSDTLAVPGSATGSLRKRLPSQDDEAEELKMLSPAASPVVAWSDPTSPQGTDDQDRATSTASQNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPEVKPAEAGQVEEEHYCEMLCCKFKRRPWKKYQFPQSIDPLTNLMYILWLFFVVLAWNWNCWLIPVRWAFPYQTPDNIHLWLLMDYLCDLIYLLDITVFQMRLQFVRGGDIITDKKEMRNNYVKSQRFKMDMLCLLPLDLLYLKFGVNPLLRLPRCLKYMAFFEFNNRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYEGLGSTHWVYDGVGNSYIRCYYWAVKTLITIGGLPDPRTLFEIVFQGLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYSIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRNNNKPKEKSVLILPPRAGTPKLFNAALAAAGKMGAKGGRGGRLALLRARLKELAALEAAARQQQLLEQAKSSEDAAVGEEGSASPEQPPRPEPPAPEAPAPEPTAPEPLAPEAPAPEAPAPSSPPPASQERPEGDKDAARPEEHPVRIHVTLGPDPSEQILLVEVPEKQEEKEKKEEETEEKEEGEEARKEKEEE
Protein: glucan endo-1,3-beta-D-glucosidase (EC 3.2.1.39) (O23953)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
FSGFLISAMVFLTQLLSLTDGRDIGVCYGLNGNNLPSPGDVINLYKTSGINNIRLYQPYPEVLEAARGSGISLSMGPRNEDIQSLAKDQSAADAWVNTNIVPYKDDVQFKLITIGNEAISGQSSSYIPDAMNNIMNSLALFGLGTTKVTTVVPMNALSTSYPPSDGAFGSDITSIMTSIMAILAVQDSPLLINVYPYFAYASDPTHISLDYALFTSTAPVVVDQGLEYYNLFDGMVDAFNAXLDKIGFGQITLIVAETGWPTXGNE
Protein: Cell wall protein SRL1 (Q08673)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required to stabilize the cell wall in the absence of multiple GPI-anchored mannoproteins.
Subcellular location: Secreted, cell wall. Cell surface.
Interaction partners:
- Covalently-linked cell wall protein 12
- SWI5-dependent HO expression protein 2
- Probable secreted beta-glucosidase SUN4
- Putative uncharacterized protein YOR248W
Sequence:
MLQSVVFFALLTFASSVSAIYSNNTVSTTTTLAPSYSLVPQETTISYADDTTTFFVTSTVYSTSWFTSTSATITNAASSSLSTSSASGSVTPESTHEITSTSTITSTLLLTLHDSTTLSPSSTAASVSDEDSNNKDAKVKSFEQASTSNGCVPITKFVTVTNEPVTQYVTVTPNTTTQYVTVTGAPSVTTTSPGNVQWYNTTSITNSTSW
Protein: dual-specificity kinase (EC 2.7.12.1) (H3BVF8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELL
Protein: RE39287p (Q6NR32)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSQFNFVSDLQNALIMDGETRGPAPRWKKKLEASLNGSVNTTRSVLSVSYNTSFSGVQAPTKTPGKSSEGKTKKSNTTPSKTPGGGDRFIPNRAATNFELAHFLVNKDSGDKSDEENYKATSSNSNESNVQASAHKGDRQKLISEVAQVGDSKGGRILCYQNKAPAAPETHNNPLKVVYSIKTPISTKSGSRYIPTTSERILDAPDFINDYYLNLMDWSADNIVAVALGSCVYLWNAQTGNIEQLTEFEEGDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSARVGSLAWNSFLVSSGSRDGTIVHHDVRAREHKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGGVGTATDPLHKFNDHQAAVRALAWCPWQPSTLASGGGTADRCIKFWNVNNGTLMKSVDSKSQVCSLLFSRHYKELISAHGFANNQLTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWNCFAPDPLASKKAVSTSKGKQSVFRQSIR
Protein: tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase (EC 2.8.4.3) ((Dimethylallyl)adenosine tRNA methylthiotransferase MiaB) (tRNA-i(6)A37 methylthiotransferase) (O31778)
Organism: Bacillus subtilis (strain 168)
Function: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01864}.
Interaction partners:
- tRNA dimethylallyltransferase
- Probable tRNA sulfurtransferase
- Uncharacterized protein YmcA
- Probable dual-specificity RNA methyltransferase RlmN
- tRNA-specific 2-thiouridylase MnmA
- Epoxyqueuosine reductase
- Putative cysteine desulfurase IscS 1
- Zinc-dependent sulfurtransferase SufU
- Biotin synthase
Sequence:
MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGKEAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDDANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKHPFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIMYGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFEDMTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSEVLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEFDSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVLVEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEVK
Protein: Ornithine decarboxylase (ODC) (EC 4.1.1.17) (P00860)
Organism: Mus musculus (Mouse)
Function: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Interaction partners:
- Ornithine decarboxylase antizyme 1
- Spermidine synthase
- Ornithine aminotransferase, mitochondrial
- Guanidino acid hydrolase, mitochondrial
- Diamine acetyltransferase 1
- Arginase-2, mitochondrial
- Arginase-1
- Ornithine decarboxylase antizyme 3
- Amine oxidase
- Amine oxidase
Sequence:
MSSFTKDEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPAERVIYANPCKQVSQIKYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLLLERAKELNIDVIGVSFHVGSGCTDPETFVQAVSDARCVFDMATEVGFSMHLLDIGGGFPGSEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQPGSDDEDESNEQTFMYYVNDGVYGSFNCILYDHAHVKALLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPNIYYVMSRPMWQLMKQIQSHGFPPEVEEQDDGTLPMSCAQESGMDRHPAACASARINV
Protein: Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) (Q92796)
Organism: Homo sapiens (Human)
Function: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 2A
- Disks large homolog 4
- Disks large homolog 2
- Disks large homolog 1
- Neurobeachin
- Ras/Rap GTPase-activating protein SynGAP
- E3 ubiquitin-protein ligase NEDD4
- Leucine-rich repeat and fibronectin type-III domain-containing protein 2
- Lethal
Sequence:
MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPGGGNGASAGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL
Protein: Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) (P0A7A9)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00209}.
Interaction partners:
- ATP synthase subunit alpha
- Polyphosphate kinase
- ATP synthase subunit b
- ATP synthase subunit c
- ATP synthase subunit delta
- ATP synthase gamma chain
- ATP synthase subunit beta
- ATP synthase subunit a
- Elongation factor P
- ATP synthase epsilon chain
Sequence:
MSLLNVPAGKDLPEDIYVVIEIPANADPIKYEIDKESGALFVDRFMSTAMFYPCNYGYINHTLSLDGDPVDVLVPTPYPLQPGSVIRCRPVGVLKMTDEAGEDAKLVAVPHSKLSKEYDHIKDVNDLPELLKAQIAHFFEHYKDLEKGKWVKVEGWENAEAAKAEIVASFERAKNK
Protein: BCL2 interacting protein 3 (BCL2/adenovirus E1B interacting protein 3 variant) (M9VYP0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
Sequence:
MSQSGEENLQGSWVELHFSNGNGSSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSLRKIILREEEKLKVS
Protein: ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) (Q6PGC1)
Organism: Mus musculus (Mouse)
Function: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03068}.
Interaction partners:
- ATP-dependent RNA helicase DDX3X
- Eukaryotic translation initiation factor 2D
- Eukaryotic translation initiation factor 1
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS11
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein eS4
Sequence:
MGGKNKKHKAPGAAAMRAAVSASRARSAEAGAVGEAQSKKPVARPAPAVPTGAREPRVKQGPKIYSFNSANDSGGSANLDKSILKVVINNKLEQRIIGVINEHKKQNSDRGAISGRLSAKKLQDLYMALQAFSFKTKDIEDAMTNTLLHGGDLHSALDWLCLNLSDDALPEGFSQEFEEQQPKSRPKFQSVQIQATLSPPQQTKTKRQEEDPKIKPKKEETTVEVNMKEWILRYAEQQDEEEKGEGSKGLEEEEKFDPNQRYLNLAARLLDAKEQAAAFKLEKNKQGQKEAQEKIRKFQREMETLEDHPIFNPAIKISHQQNEKKKPAPATEAESALNLNLFEKSAAATEEEKGKKKEPHDVRNFDYTARSWTGKSPKQFLIDWVRKNLPKSPNPSFEKVAVGRYWKCRVRVVRSEDDVLVVCPTILTEDGMQAQHLGATLALYRLVKGQSVHQLLPPTYRDVWLEWSDEEKKREELNKMETNKPRDLFIAKLLNKLKQQQQQQQQQRPESEKGGSEDPEESWENLVSDEDLAALSLEPTSAEDLAPVRSLFRRLQSTPKYQRLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLDECGARKCNIVCTQPRRISAVSLATRVCEELGCESGPGGRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDLHLILMSATVDSDKFSTYFTHCPILRISGRSYPVEVFHLEDIVEETGFVLEKDSEYCQKFLEEEEEITINVTSKAGGVKKYQEYIPVQSGASPELNPFYQKYSSRTQHAILYMNPHKINLDLILELLVYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSSDRRFYSERYQVIALHSVLSTQDQAAAFMFPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRLYTRERFEGFLDYSVPEILRVPLEELCLHIMKCDLGSPEDFLSKALDPPQLQVISNAMNLLRKIGACEPNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPFITPIGRKDEADLAKSSLAVADSDHLTIYNAYLGWKKAQQEGGFRSEISYCQRNFLNRTSLLTLEDVKQELMKLVKAAGFSSSPSWEGRKGPQTLSFQDIALLKAVLAAGLYDSVGKIMCTKSVDVTEKLACMVETAQGKAQVHPSSVNRDLQTYGWLLYQEKVRYTRVYLRETTLITPFPVLLFGGDIEVQHRERLLSVDGWIYFQAPVKIAVIFKQLRVLIDSVLRKKLENPKMSLENDKILQIITELIKTENN
Protein: COBRA-like protein 5 (Q9FME5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MESLFSTMIVLLLVSFSCLISTEALTSNYGNITVKWDLLNWTPDGYVAVVTAYNYQKQRSIPGWKMSWRGTKKEVIWNMLGAKTTGQGGCSMFKGNIPQSCVRKPTVVDLLPGTPFNQQIANCCKSGVLKPGSESAFQLSVGSAGNSVKTARMPANFMFTAPKQQYICGPSKNVRPTRFTTADKRRITAALMTWNITCVFHKAT
Protein: Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase TR2) (Q99MD6)
Organism: Mus musculus (Mouse)
Function: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11259642, ECO:0000269|PubMed:15901730}. Nucleus {ECO:0000269|PubMed:11259642, ECO:0000269|PubMed:15901730}. Microsome {ECO:0000269|PubMed:11259642, ECO:0000269|PubMed:15901730}. Endoplasmic reticulum. Note=Detected in cytoplasm and nucleus in late spermatids. {ECO:0000269|PubMed:11259642, ECO:0000269|PubMed:15901730}.
Interaction partners:
- Selenide, water dikinase 2
- Selenocysteine lyase
- Selenide, water dikinase 1
- Cystathionine gamma-lyase
- Kynurenine--oxoglutarate transaminase 1
- Thioredoxin reductase 2, mitochondrial
- Kynurenine--oxoglutarate transaminase 3
- Thioredoxin reductase 1, cytoplasmic
- Thioredoxin
- Thioredoxin reductase-like selenoprotein T
Sequence:
MEKPPSPPPPPRAQTSPGLGKVGVLPNRRLGAVRGGLMSSPPGRRARLASPGTSRPSSEAREELRRRLRDLIEGNRVMIFSKSYCPHSTRVKELFSSLGVVYNILELDQVDDGASVQEVLTEISNQKTVPNIFVNKVHVGGCDRTFQAHQNGLLQKLLQDDSAHDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKLMHQAALLGHALQDAKKYGWEYNQQVKHNWEAMTEAIQSHIGSLNWGYRVTLREKGVTYVNSFGEFVDLHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLEQQGVKFQRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGLEKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSLEKCDYINIPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDNNTCYAKIICNKFDNERVVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG
Protein: Histone-lysine N-methyltransferase set5 (EC 2.1.1.-) (O74467)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P38890}. Chromosome {ECO:0000250|UniProtKB:P38890}. Cytoplasm {ECO:0000250|UniProtKB:P38890}.
Interaction partners:
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- Histone H4
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
Sequence:
MNPYETEIYKVVPIPNKGMGMIAKVKIPVGTRIFAETPLIRTKSDAKEIEEALSTKTKEEQEAFHRLFNAHPDTMGPFLGPFYSNALTIDETKGGMFLLGSRMNHDCSPNVKHTWNPRLDQVTVHAVRDIEAGEEILTTYIDLHKSHTERQKILLEHFGFKCYCSVCSVEERKIRKISDLRRKQLAYYDRTMAKMCIVNPRGALRALRHRIHIAHEELLFGRLDIIALLDAFRLCVIHGDFERASIFAKKGTKAISLYEGTDSEKYLKISKYVENPRSHALAEGVPALPLFLEEDDELSDLEDNLWGCKLEEDVYSDTD
Protein: Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase) (P16622)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the ferrous insertion into protoporphyrin IX.
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=It is bound to the mitochondrial inner membrane in eukaryotic cells with its active site on the matrix side of the membrane.
Interaction partners:
- Protoporphyrinogen oxidase
- Frataxin homolog, mitochondrial
- Uroporphyrinogen decarboxylase
- Protoheme IX farnesyltransferase, mitochondrial
- 5-aminolevulinate synthase, mitochondrial
- Holocytochrome-c synthase
- Oxygen-dependent coproporphyrinogen-III oxidase
- Holocytochrome-c1 synthase
- Uroporphyrinogen-III synthase
- Delta-aminolevulinic acid dehydratase
Sequence:
MLSRTIRTQGSFLRRSQLTITRSFSVTFNMQNAQKRSPTGIVLMNMGGPSKVEETYDFLYQLFADNDLIPISAKYQKTIAKYIAKFRTPKIEKQYREIGGGSPIRKWSEYQATEVCKILDKTCPETAPHKPYVAFRYAKPLTAETYKQMLKDGVKKAVAFSQYPHFSYSTTGSSINELWRQIKALDSERSISWSVIDRWPTNEGLIKAFSENITKKLQEFPQPVRDKVVLLFSAHSLPMDVVNTGDAYPAEVAATVYNIMQKLKFKNPYRLVWQSQVGPKPWLGAQTAEIAEFLGPKVDGLMFIPIAFTSDHIETLHEIDLGVIGESEYKDKFKRCESLNGNQTFIEGMADLVKSHLQSNQLYSNQLPLDFALGKSNDPVKDLSLVFGNHEST