wanglab/gogpt-training-data huggingface dataset:
Protein: 5-keto-D-gluconate 5-reductase (EC 1.1.1.69) (P0A9P9)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli to utilize L-idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD.
Interaction partners:
- L-idonate 5-dehydrogenase
- Thermosensitive gluconokinase
- Gnt-II system L-idonate transporter
- HTH-type transcriptional regulator IdnR
- 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
- NADH-quinone oxidoreductase subunit C/D
Sequence:
MNDLFSLAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQAVAAPFNVTHKHEIDAAVEHIEKDIGPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTAVFLVSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAASKGAVKMLTRGMCVELARHNIQVNGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVNGHLLFVDGGMLVAV
Protein: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Q9R1J0)
Organism: Mus musculus (Mouse)
Function: Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis. Plays a role in the regulation of the endocytic trafficking of EGFR.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14506130}; Single-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000269|PubMed:14506130}. Note=Trafficking through the Golgi is necessary for ER membrane localization. {ECO:0000269|PubMed:14506130}.
Interaction partners:
- Methylsterol monooxygenase 1
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Lanosterol 14-alpha demethylase
- Squalene monooxygenase
- Lathosterol oxidase
- Lanosterol synthase
- Squalene synthase
- 7-dehydrocholesterol reductase
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Diphosphomevalonate decarboxylase
Sequence:
MEQAVHGESKRGQVTGTHLTNDISKAKKCTVIGGSGFLGQHMVEQLLERGYTVNVFDIHQGFDNPRVQFFIGDLCNQQDLYPALKGVSTVFHCASPPPYSNNKELFYRVNFIGTKTVIETCREAGVQKLILTSSASVVFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLDANDPKKNFLTAAIRPHGIFGPRDPQLVPILIDAARKGKMKFMIGNGENLVDFTFVENVVHGHILAAEHLSQDAALGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWMAYYLAFLLSLLVMVVSPLIQIQPTFTPIRVALAGTFHYYSCEKAKKLFGYRPLVTMDEAVERTVQSFHHLRKDK
Protein: Protein NBR1 homolog (AtNBR1) (At4g24690) (Q9SB64)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Autophagic substrate degraded in the vacuole by non-selective autophagy. Requires ATG8 protein expression to be recognized as an autophagic substrate. Acts probably as a receptor for autophagosomal degradation of ubiquitinated proteins. Targets ubiquitinated protein aggregates derived from denatured or damaged non-native proteins generated under stress conditions. Functions additively with the E3 ubiquitin-protein ligase CHIP for autophagosomal degradation of proteotoxic aggregates formed under stress conditions.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21606687}. Vacuole {ECO:0000269|PubMed:21606687}. Note=Forms large punctated cytoplasmic structures. Recruited to the central vacuole by non-selective autophagy. {ECO:0000269|PubMed:21606687}.
Interaction partners:
- Autophagy-related protein 8a
- Autophagy-related protein 8f
- Autophagy-related protein 8c
- Autophagy-related protein 8b
- Autophagy-related protein 8d
- Autophagy-related protein 8e
- Autophagy-related protein 8g
- Autophagy-related protein 8i
- Autophagy-related protein 8h
- Ubiquitin-ribosomal protein eL40y fusion protein
Sequence:
MESTANALVVKVSYGGVLRRFRVPVKANGQLDLEMAGLKEKIAALFNLSADAELSLTYSDEDGDVVALVDDNDLFDVTNQRLKFLKINVNAGVSTNSAAPESSGSSTPAGMPNPVSKIQKGINDVLMAVPNPMRDTISKVYMDLASKASTSSPVVGEMLDCISKLGQLSIPQESSPCSPVTKPGSSGASLSRDVPSAGGKKDISERTQTGRKPVNLNEPTGAHSKTSGHVPNSSGLGANFNECPFSGSTMNYSCPNPVNLNKHPRRVCHSKKSTNGDYWTSLGVFHKGIRCDGCGVLPITGPRFKSKVKEDYDLCTICYSVMGNEGDYTRMDKPVSVQHLHPFRGPFTQFPNPWLSHPVPRATNGGAPLRCTRPKLDSRFVLDVNVIDGTVVAPSAPFTKIWKMRNSGSLVWPQGTQIVWIGGDRFCNSLSVDLQIPKEGVPIYSELDVKVDFVAPELPGRYISYWRMATSDGAKFGQRVWVLIHVDASLKNSVVNEFHGLNLNASPSLDENFPSEFLGIMNYESAQPGSSSVNPGTVKGTDLEGEVGETQAVEKENLLVGEAHPAIPHGHSPSSSSSSFNMVDFPSMPAVEVLSGGSSSTTKDVPVPLQEDIEKNDVEITMLKELEEMGFKEIDLNKEILRDNEYNLEQSVDALCGVSEWDPILEELQEMGFCDDVTNKRLLKKNNGSIKGVVMDLLTGEKEA
Protein: Protein ETHYLENE-INSENSITIVE 3-like 1a (EIN3-like protein 1a) (OsEIL1a) (OsEIL1) (Protein MAO HUZI 6) (Q10M41)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor acting as a positive regulator in the ethylene response pathway. Required for the inhibition of root growth by ethylene in etiolated seedlings. Functions upstream of the auxin biosynthetic gene YUCCA8 and directly activates its expression. Functions downstream of the ethylene signaling factor EIN2 in disease resistance against the rice blast fungus (Magnaporthe oryzae). Binds directly to the promoters of the NADPH oxidases RBOHA and RBOHB, and the jasmonate biosynthetic gene OPR4 to activate their expression during fungal infection. May enhance disease resistance by facilitating reactive oxygen species (ROS) generation and jasmonate biosynthesis with subsequent phytoalexin accumulation during Magnaporthe oryzae infection. Acts as negative regulator of salt tolerance. During salt stress, activates the cation transporter HKT1, which mediates increased sodium uptake in roots, and contributes to sodium accumulation and salt toxicity. Binds directly to the DNA sequence 5'-TGTTACAAATACC-3' in the promoter of the GA20OX2 gene to activate its expression at the transcriptional level during ethylene signaling. Possesses transactivation activity in protoplasts.
Subcellular location: Nucleus {ECO:0000269|PubMed:25995326}.
Interaction partners:
- Protein ETHYLENE-INSENSITIVE 2
- Os06g0605900 protein
- Os02g0200900 protein.
- Mitogen-activated protein kinase 5
- Mitogen-activated protein kinase 1
- AP2 domain containing protein, expressed
- Os09g0572000 protein
- Os07g0156732 protein
- Transcription factor MYC2
- Natural resistance-associated macrophage protein, expressed
Sequence:
MMGGGLVMDQGMMFPGVHNFVDLLQQNGGDKNLGFGALVPQTSSGEQCVMGEGDLVDPPPESFPDAGEDDSDDDVEDIEELERRMWRDRMKLKRLKELQLSRGKDPAGGVVGDPSKPRQSQEQARRKKMSRAQDGILKYMLKMMEVCRAQGFVYGIIPEKGKPVSGASDNLRGWWKEKVRFDRNGPAAIAKYQADNAVPGFESELASGTGSPHSLQELQDTTLGSLLSALMQHCDPPQRRYPLEKGVPPPWWPTGDEEWWPELGIPKDQGPPPYKKPHDLKKAWKVSVLTAVIKHMSPDIEKIRRLVRQSKCLQDKMTAKEISTWLAVVKQEEELYLKLNPGARPPAPTGGITSAISFNASSSEYDVDVVDDCKGDEAGNQKAVVVADPTAFNLGAAMLNDKFLMPASMKEEATDVEFIQKRSASGAEPELMLNNRVYTCHNVQCPHSDYGYGFLDRNARNSHQYTCKYNDPLQQSTENKPSPPAIFPATYNTPNQALNNLDFGLPMDGQRSITELMNMYDNNFVANKNLSNDNATIMERPNAVNPRIQIEEGFFGQGSGIGGSNGGVFEDVNGMMQQPQQTTPAQQQFFIRDDTPFGNQMGDINGASEFRFGSGFNMSGAVEYPGAMQGQQKNDGSNWYY
Protein: Type IV inositol polyphosphate 5-phosphatase 9 (At5PTase9) (EC 3.1.3.36) (EC 3.1.3.86) (Q9SIS4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Has phosphatase activity toward PtdIns(4,5)P2 and at a lower extent toward PtdIns(3,4,5)P3 but not toward Ins(1,4,5)P3. Functions in salt stress response by regulating reactive oxygen species (ROS) production, endocytosis, Ca(2+) influx and stress-responsive genes expression.
Interaction partners:
- Phosphoinositide phosphatase SAC6
- Phosphoinositide phosphatase SAC7
- Phosphoinositide phosphatase SAC8
- Putative cysteine-rich receptor-like protein kinase 32
- F21F23.12 protein
- Sorting nexin 2A
- Zinc finger CCCH domain-containing protein 48
- Protein FAR1-RELATED SEQUENCE 3
- Protein EXORDIUM-like 2
Sequence:
MWPRLVANKILRKSLGSNNFVADFPPNTDQKLIEASGLADERSKSILHNQHKTTLLNYKVFVSTWNVGGIVPDDGLDMEDLLETHKTPCDIYVLGFQEVVPLRASNVLGSDNNKVSTKWNSLIRDALNKRARPHRDEDLSESKGINGISQDFRCIISKQMVGILITVWVRGDLWPYIRYPSVSCVGCGIMGCLGNKGSVSVRFQLHETTFCFVCSHLASGGRDRDERQRNSDVNEILARSSFPRGSSLDLPKKILDHDRVIFLGDLNYRISLPEEKTRLLVESKKWNILLENDQLRMEIMNGQIFRGWQEGIVKFAPTYKYVPNSDLYYGCITYKKDEKKRAPAWCDRIIWYGNGLKQHEYTRGETKISDHRPVKAIFTTEITVTRRGKKIRNFFFSDRFEERIGDIDSKDYSWIST
Protein: C-C chemokine receptor type 7 precursor (Zgc:165629 protein) (A5PLI3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early endosome {ECO:0000256|ARBA:ARBA00004412}.
Interaction partners:
Sequence:
MHAYTVFCPVLLIWSCHIKKSWSNMTEHQMGEKATTEYDYTTGTVDYDIYEQSCNKTNNRTFRAWFLPTIYTIICLLALMGNFLVILTYLYFKRLKTMTDVYLFNLAMADLLFAISLPFWAASFMSTWHLGLYPCKAMFTIYKVSFFSGMFLLTCISIDRYFSITKAVSAHRCRSSAVYYGQVSSLVTWVIAIVFSVPDMVFAVINSRGTCSANVNYQDYYVKMVISQMVLGFIIPAVVMGFCYICIIKTLMQAKNFERNKAFKVIIAVVVVFVFSQLPYNVVMGVSVQQTTDCAKDNTRLFALDVTMAVAFLRCCVNPFLYAFIGVKFRNDLLKLLKDLGCLRTSHLMYTHCGRRRSSVGLDTETTTTFSP
Protein: IQ motif and ubiquitin-like domain-containing protein (Q8NA54)
Organism: Homo sapiens (Human)
Function: May play roles in cilia formation and/or maintenance.
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q8CDK3}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8CDK3}. Note=Localizes to the axoneme of sperm cells and the cilia of tracheal epithelial cells. {ECO:0000250|UniProtKB:Q8CDK3}.
Interaction partners:
Sequence:
MSNQQEKYEAQNIVNSTEESDDAFDTVTIPVPSEEPQESDQTEEHESGIEQFSESHAIHVEEQSDQSFSSLEPDNEQLMEEVISPRQVSYTPQHHEKQYAMQRPNDDSLAFLDKIKSVKESLQESVEDSLATVKVVLIPVGQEIVIPFKVDTILKYLKDHFSHLLGIPHSVLQIRYSGKILKNNETLVQHGVKPQEIVQVEIFSTNPDLYPVRRIDGLTDVSQIITVTVQTGLDQYQQVPVEIVKSDFHKPFLGGFRHKVTGVEYHNAGTQTVPKRIPERLSIFCRDTQTVFQKKNLQQTTNTTSTQMTNIGVYVSNMTDKLVTPGKYFSAAEYHAQRLKAVIVIQTYYRQWHAKIFVENLRRQKSLRLEWETQQELRKIREKEEWIKLDYHRRHNPKTNEDFEFLYNALEFWRQEELTRINQSFTGAERKAALCELLEKETQIIASIGRHRYIAYMANQEAAIQAFLDKCSAPKIWRTPNGKTIEMDTQFTIRARELQNIYKCIMLKNISQDERLDVLLTLKHTVKEHECKLTQEILELIDREVDLMMRGVKHHNLEGLRKRIATLFFHYIKTPLFNPEVAKYLKVPQDPLKFYKKIYFCHSCQLYLPSTEFSVSSTSRRIYRCRNCINLQNEAQKRESFLKYKCLLQQLYYTEADYEDDSKIAFLMQLQDIQYLTENIWASQSVLSACDNLSDLVMVRWNKSLEWSPWNCILLTKDEAAAHLKLTSIEEGYERSFIHKIKHKHILAKNYFSQVPVLASFILDDGEIDEIRWKYHSDTTPKIIESQRPPH
Protein: Appendage-associated protein (Q5SF96)
Organism: Anaplasma marginale (strain St. Maries)
Function: Associates with actin filament appendages that are formed in the inclusion appendages of the parasitophorous vacuole during infection of the host erythrocyte.
Subcellular location: Secreted {ECO:0000269|PubMed:15557651}.
Interaction partners:
Sequence:
MIVTYGTVGCPVSRGGSPGCGRRIAEELRLAEDARLRLALLGRCIVKGSPAQARGELRAELKAIDATIELRKELDAIDAEWAPKIELSAELRAIDAEWRPAIRLRSAYRAIIGRIELRKELDAIDAEWAPKIELSAELKAIDAEWRPAIRLRSAYRAIIGRWELSKELKAIDAEWRPAIARESLRKELDAIDAEWQHAITFWHISRAIIGSIELSKELKAIDAKWKYVAIYERQKAQRRREERAAKAREELRKELNDIDAKWKSASAIKLRKDLRSTSEGVDHTEFALELRATDKSGNMELVLKLKATDTKNQHDAIVKAIEDGFVGYAAECGAATRELNACGGMSTTSAPSTDLISTVVSAVTTGTGQQQSAGSESQRPTECGGGGTLLSSLFALILPSSNWYCNAVLYGGFLGCLGS
Protein: 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (DHNA-CoA hydrolase) (EC 3.1.2.28) (DHNA-CoA thioesterase) (P77781)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA). Also shows significant activity toward a wide range of acyl-CoA thioesters, and minimal activity toward benzoyl-holoEntB.
Interaction partners:
- 1,4-dihydroxy-2-naphthoyl-CoA synthase
- 1,4-dihydroxy-2-naphthoate octaprenyltransferase
- D-2-hydroxyglutarate dehydrogenase
- Sugar phosphatase YidA
- Acyl-CoA thioester hydrolase YciA
- 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
- Acyl-CoA thioester hydrolase YbgC
- Acyl-CoA thioesterase 2
- Isochorismate synthase MenF
- 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Sequence:
MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL
Protein: Calcium homeostasis modulator protein (Q18593)
Organism: Caenorhabditis elegans
Function: Pore-forming subunit of a voltage-gated ion channel. Permeable to monovalent cations, divalent cations and anions with selectivity Ca(2+) > Mg(2+) > Na(+) = K(+) > Cl(-). Acts both as a voltage-gated and calcium-activated ion channel. Required for normal locomotion.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23884934}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Sodium/calcium exchanger membrane region domain-containing protein
- Mitochondrial sodium/calcium exchanger protein
Sequence:
MTTSINSVVTVFQNVFTNHGSTLLNGILIATTVGGQSLVRKLTFSCPCAYPLNIYHSLVFMFGPTAALLLIGITVNSTTWKLAHGFFFRVRDTRHSWKTTCVSWIEVLIQSSVAPIAWLFVVFLDGGYYRCYRSHEFCLISDAILCKNSTILNSYASTSSFNKISDNGKYCPPCICVPNPTDASYLEAESQIYAWGLLLFSGVAAFLVITCNRMCDKYTLVQRQYVETYKNVETQKFDAVAKEHASQLAEHNARAFFGQKDWTKRDWDWVSGIPEVNNPLFARLRLIAAEKTQQTMYTPLQLWNDNKGYRIPQPDLQLTQIIVDETKED
Protein: Replication factor C subunit 1 (AtRFC1) (Activator 1 large subunit) (Activator 1 subunit 1) (Q9C587)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role as mediator of transcriptional gene silencing (TGS), DNA replication, DNA repair, hypersensitive response (HR) and telomere length regulation. Is required in meiosis for DNA double-strand break (DSB) repair during meiotic homologous recombination. May participate in the RAD51-mediated recombination intermediate repair process. Is important for lagging strand synthesis. Promotes meiotic recombination via a specific pathway for crossovers (COs) that involves the formation of double Holliday Junction (dHJ) intermediates.
Subcellular location: Nucleus {ECO:0000269|PubMed:20639449, ECO:0000269|PubMed:22974522}. Note=Localizes to the chromosomes during zygotene and pachytene.
Interaction partners:
- Replication factor C subunit 3
- Replication factor C subunit 2
- Replication factor C subunit 5
- Proliferating cell nuclear antigen 2
- Proliferating cellular nuclear antigen 1
- Flap endonuclease 1
- DNA polymerase epsilon catalytic subunit A
- Replication factor C subunit 4
- DNA polymerase alpha catalytic subunit
- Cell cycle checkpoint protein RAD17
Sequence:
MSDIRKWFMKAHEKGNGSAPKSTSSKAGPVKNAAETAPIKSEQASEDLETADRRKTSKYFGKDKTKVKDEKEVEAIPAKRKLKTESDDLVKPRPRKVTKVVDDDDDDFDVPISRKTRDTTPSKKLKSGSGRGIASKTVDNDDDDDGEDKETPLKSAGRGRGGRAAPGASTGGRGRGGGRGGFMNFGERKDPPHKGEKEVPEGTPDCLAGLTFVISGTLDSLEREEAEDLIKRHGGRITGSVSKKTTYLLCDEDIGGRKSEKAKELGTKFLTEDGLFDIIRSSKPVKKSLPERSNKGTEKICAPPKTSPQKEETRGKPLAKSSPKKVPPAKGKNKIIETSLPWTEKYRPKVPNEIVGNQSLVTQLHNWLSHWHDQFGGTGSKGKGKKLNDAGSKKAVLLSGTPGIGKTTSAKLVSQMLGFQAVEVNASDSRGKANSNIAKGIGGSNANSVKELVNNEAMAANFDRSKHPKTVLIMDEVDGMSAGDRGGVADLIASIKISKIPIICICNDRYSQKLKSLVNYCLPLNYRKPTKQQMAKRLMHIAKAEGLEINEIALEELAERVNGDIRLAVNQLQYMSLSMSVIKYDDIRQRLLSSAKDEDISPFTAVDKLFGYNGGKLRMDERIDLSMSDPDLVPLLIQENYLNYRPSGKDEAKRMDLLARAAESIADGDIINVQIRRYRQWQLSQSCCVASSILPASLLHGSREVLEQGERNFNRFGGWLGKNSTAGKNRRLMEDLHVHVLASRESSAGRETLRVDYLPLLLSRLTSPLQTLPKDEAVSEVVDFMNSYSISQEDFDTILELGKFKGRENPMEGVPPPVKAALTKKYNEMNKTRMVRVADMVQLPGVKKAPKKRIAAMLEPTVDSLRDEDGEPLADNEEGNGSDAEEDSEEATDGEKLESNLKNLNARGIQVELDLKGAGSSGSRKAAGKGRGRGKAADTSAEKKATGRGSGAKRKR
Protein: L-type lectin-domain containing receptor kinase IX.1 (LecRK-IX.1) (EC 2.7.11.1) (Q9LXA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes hydrogen peroxide H(2)O(2) production and cell death.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9LSR8}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- S-protein homolog 2
- Anaphase-promoting complex subunit 11 RING-H2 finger protein
- Histone deacetylase
- Transmembrane protein
- Secreted protein
- Uncharacterized protein
- Inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein, putative
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
Sequence:
MANSILLFSFVLVLPFVCSVQFNISRFGSDVSEIAYQGDARANGAVELTNIDYTCRAGWATYGKQVPLWNPGTSKPSDFSTRFSFRIDTRNVGYGNYGHGFAFFLAPARIQLPPNSAGGFLGLFNGTNNQSSAFPLVYVEFDTFTNPEWDPLDVKSHVGINNNSLVSSNYTSWNATSHNQDIGRVLIFYDSARRNLSVSWTYDLTSDPLENSSLSYIIDLSKVLPSEVTIGFSATSGGVTEGNRLLSWEFSSSLELIDIKKSQNDKKGMIIGISVSGFVLLTFFITSLIVFLKRKQQKKKAEETENLTSINEDLERGAGPRKFTYKDLASAANNFADDRKLGEGGFGAVYRGYLNSLDMMVAIKKFAGGSKQGKREFVTEVKIISSLRHRNLVQLIGWCHEKDEFLMIYEFMPNGSLDAHLFGKKPHLAWHVRCKITLGLASALLYLHEEWEQCVVHRDIKASNVMLDSNFNAKLGDFGLARLMDHELGPQTTGLAGTFGYMAPEYISTGRASKESDVYSFGVVTLEIVTGRKSVDRRQGRVEPVTNLVEKMWDLYGKGEVITAIDEKLRIGGFDEKQAECLMIVGLWCAHPDVNTRPSIKQAIQVLNLEAPVPHLPTKMPVATYHVSSSNTTSVSSGGATVTFSSAQHGR
Protein: Nucleoporin 58kDa L homeolog (Nupl1 protein) (A4FU91)
Organism: Xenopus laevis (African clawed frog)
Subcellular location: Nucleus, nuclear pore complex {ECO:0000256|ARBA:ARBA00004567}.
Interaction partners:
Sequence:
MASGFAFAAAAGTATLNPAAGAVAPFSFGGTPAASNTGTTGGLAFGAFGAAATPATTTAATGLGGGLFGAKPATGFTLGGANTATATTTSASTGFSIGFNKPAGSATPFSLPVTSTSSGGLSLASALTSTPATGPSPFTLNLGSTPATTTAASIGLSLGGTLTGLGGSLFQNINPSTGLGQITLGQNTLGLGLNLGAVAPVSQATTHEGLGGLDFSNSSDKKSQKAGARPEDSKALKDENLPQLLCQDVENFQKFVKQQKQVQEEISRMSSKAMLKVQEDIKALKQLLSVASSGLQRNALAIDKLKIETAQELKNAEIALRTQKTPPGLQHENTAPAYYFHTLVQQFEVQLQQYRQQIEELENHLATQSNSLHLSPQDLSMAMQKLYQTFVALAAQLQAVNENFKMLKEQYLGYRKTFLGDSTDVFEARRAEAKKWQSAPRVTTGPTPFSNIPNAAAVAMAATLTQQQQPTTGPRPSLGVSFGTPFGSAMNAGLQPSGLGSSGLGGFGSSSAFGGNTSGSSSFGFGTANKPSGSLSAGFGSTSTSGFNFSNPGINASAGLTFGVSNPSSTGFGTAGQLLQLKKPPTGNKRGKR
Protein: ATP synthase subunit beta (EC 7.1.2.2) (Q57XX1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- ATP synthase F1 subunit gamma protein, putative
- ATP synthase alpha chain
- ATP synthase, epsilon chain, putative
- ATPase subunit 9, putative
- ATPase subunit 9, putative
- ATPase subunit 9, putative
- Cytochrome c1, heme protein, mitochondrial
- Uncharacterized protein
- Ribonucleoprotein p18, mitochondrial, putative
- Uncharacterized protein
Sequence:
MLTRFRSAVLRGAVSITGARAASTAPVADHKGRVGHVSQVIGAVVDVHFADGVPPVLTALDVVDKLGRDEPLTLEIVQHLDAHTGRCIAMQTTDLLKLKAKVVSTGGNISVPVGRETLGRIFNVLGDAIDQRGPVGEKLRMPIHAVAPKLADQAAEDAVLTTGIKVIDLILPYCKGGKIGLFGGAGVGKTVIIMELINNVAKGHGGFSVFAGVGERTREGTDLYLEMMQSKVIDLKGESKCVLVYGQMNEPPGARARVAQSALTMAEYFRDVEGQDVLLFIDNIFRFTQANSEVSALLGRIPAAVGYQPTLAEDLGQLQERITSTTKGSITSVQAVYVPADDITDPAPATTFSHLDATTVLDRAVAESGIYPAVNPLECASRIMDPDVISVDHYNVAQDVVQMLTKYRELQDIIAVLGIDELSEEDKLIVDRARKLVKFLSQPFQVAEVFTGMTGHYVQLDDTIDSFSGLLMGTYDQVPEMAFYMVGGINSVLEKAKKMAEEAAELEKMRRARVAQASS
Protein: Condensin complex subunit 2 (Barren homolog) (CAPH homolog) (P38170)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.
Subcellular location: Nucleus {ECO:0000269|PubMed:10749931}. Cytoplasm {ECO:0000269|PubMed:10749931}. Chromosome {ECO:0000269|PubMed:10749931}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Interaction partners:
- Structural maintenance of chromosomes protein 2
- Condensin complex subunit 1
- Structural maintenance of chromosomes protein 4
- Condensin complex subunit 3
- Structural maintenance of chromosomes protein 3
- Structural maintenance of chromosomes protein 1
- DNA topoisomerase 2
- Structural maintenance of chromosomes protein 5
- Aurora kinase
- Structural maintenance of chromosomes protein 6
Sequence:
MTTQLRYENNDDDERVEYNLFTNRSTMMANFEEWIKMATDNKINSRNSWNFALIDYFYDLDVLKDGENNINFQKASATLDGCIKIYSSRVDSVTTETGKLLSGLAQRKTNGASNGDDSNGGNGEGLGGDSDEANIEIDPLTGMPISNDPDVNNTRRRVYNRVLETTLVEFETIKMKELDQELIIDPLFKKALVDFDEGGAKSLLLNTLNIDNTARVIFDASIKDTQNVGQGKLQRKEEELIERDSLVDDENEPSQSLISTRNDSTVNDSVISAPSMEDEILSLGMDFIKFDQIAVCEISGSIEQLRNVVEDINQAKDFIENVNNRFDNFLTEEELQAAVPDNAEDDSDGFDMGMQQELCYPDENHDNTSHDEQDDDNVNSTTGSIFEKDLMAYFDENLNRNWRGREHWKVRNFKKANLVNKESDLLEETRTTIGDTTDKNTTDDKSMDTKKKHKQKKVLEIDFFKTDDSFEDKVFASKGRTKIDMPIKNRKNDTHYLLPDDFHFSTDRITRLFIKPGQKMSLFSHRKHTRGDVSSGLFEKSTVSANHSNNDIPTIADEHFWADNYERKEQEEKEKEQSKEVGDVVGGALDNPFEDDMDGVDFNQAFEGTDDNEEASVKLDLQDDEDHKFPIRENKVTYSRVSKKVDVRRLKKNVWRSINNLIQEHDSRKNREQSSNDSETHTEDESTKELKFSDIIQGISKMYSDDTLKDISTSFCFICLLHLANEHGLQITHTENYNDLIVNYEDLATTQAAS
Protein: Nedd4 family interacting protein (SD09769p) (Q9VVJ5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- E3 ubiquitin-protein ligase Su
- E3 ubiquitin-protein ligase Nedd-4
- E3 ubiquitin-protein ligase Smurf1
- Protein Malvolio
Sequence:
MPHNNQPSPGDDQLGPPKADFSAPPPYEANVGHGQQVALPAQMPPLALATPDPSQIPIQMQVQLPSQADLMNAQLPPEIHGKLPTYEEVQMEKSLNGELPPAFLTLPSSQQLPPPPNPLLPPNPLRDGAAAVRSAQPALTFIAIDASDPENSLSTTDNLLGTDIMFITAFIVAFLFNWIGFLMLTCFCHTIAARYGALSGFGLSLAKWTLIVKHSTDLASHENSWLWWLICAFGFLISIRALIQYVSIKRSWRLLSASAQERLLFFY
Protein: Pupal cuticle protein Edg-84A (P27780)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the cuticle of the pupa of fruit fly.
Interaction partners:
- Pupal cuticle protein Edg-78E
Sequence:
MLVKTALFVTLIGLAQAGPLPAKSSGSEDTYDSHPQYSFNYDVQDPETGDVKSQSESRDGDVVHGQYSVNDADGYRRTVDYTADDVRGFNAVVRREPLSSAAVVVKPQATAVVPKVQLKPLKKLPALKPLSQASAVVHRSFAPVVHHAPVTHVVHHAAPAHSFVSHHVPVLKTTVHHAHHPHAISYVF
Protein: Probable lipase/esterase LipG (P96935)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Uncharacterized protein Rv0647c
- Monoacylglycerol lipase
- Mycolic acid methyltransferase MmaA1
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Thioesterase TesA
Sequence:
MDIRSGTAVSGDVKLYYEDMGDLDHPPVLLIMGLGAQMLLWRTDFCARLVAKGLRVIRYDNRDVGLSTKTERHRPGQPLATRLVRSWLGLPSQAAYTLEDMAADAAALLDHLDVKHAHVVGASMGGMIAQIFAARFAQRTKTLAVIFSSNNHRFLPPPAPRALLALLTGPPPDSPRDVIVDNAVRVSKIIGSPAYPIPEDQVRAEAAESYDRNFHPWGIAQQFSAILGSGSLLRYDRRIVAPTVVIHGRADKLMRPFGGRAVARAINGARLVLIDGMGHDLPRQLWDRVIGELTRNFSEAG