wanglab/gogpt-training-data huggingface dataset:
Protein: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Colonic system B0+ amino acid transporter CATB0+) (Solute carrier family 6 member 14) (Q9JMA9)
Organism: Mus musculus (Mouse)
Function: Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract. Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner. Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (By similarity). Can also transport carnitine, butyrylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-).
Subcellular location: Membrane {ECO:0000305|PubMed:11306651}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:11447016}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Neutral amino acid transporter B
- Y+L amino acid transporter 2
- b
Sequence:
MDRLKCPNFFKCRQKEKVTASSENFHVGENDENQERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISVFVAIYYNVIIAYSLYYLFASFQSVLPWANCSSWADENCSRTPIVTGCNVSIGAGEMFMNISWVNTNNLTCLNGSEVFRPGQLPSEQYWDKVTLQRSSGMDETGVVVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPAGPFWSILFFFMLLTLGLDSQFASIETITTTFQDLFPKAMKRMRVPITLGCCLILFLLGLLCVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWIFWLWWRACWFVITPILLSAILVWSLVKFHRPDYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVQAEGNILQRIISCCRPASNWGPYLEKHRGERYRDMAEPAKETDHEIPTISGSTKPE
Protein: Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (P59722)
Organism: Rattus norvegicus (Rat)
Function: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16765982}. Nucleus {ECO:0000269|PubMed:16765982}. Note=Mainly cytoplasmic. Shuttles between the nucleus and cytoplasm. Nuclear export requires functional XPO1. {ECO:0000250|UniProtKB:Q9GZT9}.
Interaction partners:
- Hypoxia-inducible factor 1-alpha
- Endothelial PAS domain-containing protein 1
- Hypoxia-inducible factor 3-alpha
- von Hippel-Lindau disease tumor suppressor
- Protein OS-9
- Protein kinase C beta type
- Protein kinase C gamma type
- Aryl hydrocarbon receptor nuclear translocator
- Elongin-C
- Prolyl hydroxylase EGLN3
Sequence:
PRAQPAPAQPRVAPPPGGAPGAARAGGAARRGDSSTAASRVPGPEDATQAGSGPGPAEPSSEDPPPSRSPGPERASLCPAGGGPGEALSPSGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGRETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCSGKLGNYRINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELKPNSVSKDV
Protein: Cytokine receptor family member b17 (Interferon gamma receptor 1) (B3DJ98)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MRILICLIVLVFIPRSASQAVSQPSFSHPSPANLSILCDNYGVEIRWDYPDTRHGVSFQVEVNDQLKQRKRDETTNRFLNISRLLSRAAYNDYNVTVKALWNEHRLISSSSIQFTFNQHGSSKIKCRLDFPEVKLSPRNNKLHVQFINPLHLYRNTPVLGNLTEHLTYFITTDTDSKEFTCKINNRTCEAYMSFPEIQDRYCVYLDGDIGQISFNNIRSCYTGELRDYPPTTVFLYSLLGVCVTLLVITGIILLLVKKCNAEIKKKASSAFPAFLEDMKSSNRNPLENKPENVFSTVLIEPADPKPKEQALLLEDSNELEQLYGSTDVENTDTDTKSTTAGSVILDDELDELQDGYDCPHALKVEIDNGDIVDAYGPRGEVLDL
Protein: Probable inactive poly [ADP-ribose] polymerase SRO5 (Protein SIMILAR TO RCD ONE 5) (Q9FJJ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable inactive ADP-ribosyltransferase that may be involved in stress and developmental responses.
Subcellular location: Nucleus matrix {ECO:0000269|PubMed:20226034}. Note=Speckle-like pattern.
Interaction partners:
- Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial
- Endoribonuclease Dicer homolog 2
- Protein SUPPRESSOR OF GENE SILENCING 3
- Ras-related protein RABB1b
- Endoribonuclease Dicer homolog 1
- RNA-dependent RNA polymerase 6
- DNA-directed RNA polymerase IV subunit 1
- Transcription initiation factor TFIID subunit 4
Sequence:
MDYVRTQVEAVFDDSEQDGSTISESGSCDSSSDRSFADELGLMELLEGDKAHDLIYRNCKSGLGDQCQILSVLRNGFRNVGSRAKLKTFQVFQEAVQMKHGGDGGAKVKYGWCSVSKHELKTIFEYGFSEPLRNDGSFGRGLYLSPDNSPLDCLKDSASESEDGMRFLLLCRVLLGKSEIVPQGSTRSCPSSPEFDSGVDDLVSTKKYIVWSTHMNTHVLPEFLVCIKAPFNLTRSPKRLRSPWMAFPVLIKALSKFLPPSQILVIQKHYKDQQNRRITRSELIQRVRSITGDKLLVHIIKACGHKVQH
Protein: Olfactory receptor 11H4 (Olfactory receptor OR14-36) (Q8NGC9)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Receptor-transporting protein 2
Sequence:
MSFFFVDLRPMNRSATHIVTEFILLGFPGCWKIQIFLFSLFLVIYVLTLLGNGAIIYAVRCNPLLHTPMYFLLGNFAFLEIWYVSSTIPNMLVNILSKTKAISFSGCFLQFYFFFSLGTTECLFLAVMAYDRYLAICHPLQYPAIMTVRFCGKLVSFCWLIGFLGYPIPIFYISQLPFCGPNIIDHFLCDMDPLMALSCAPAPITECIFYTQSSLVLFFTSMYILRSYILLLTAVFQVPSAAGRRKAFSTCGSHLVVVSLFYGTVMVMYVSPTYGIPTLLQKILTLVYSVTTPLFNPLIYTLRNKDMKLALRNVLFGMRIRQNS
Protein: Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] (Q99315)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the genomic RNA-nucleocapsid complex.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1371165}. Nucleus {ECO:0000269|PubMed:1371165}.
Interaction partners:
Sequence:
MSFMDQIPGGGNYPKLPVECLPNFPIQPSLTFRGRNDSHKLKNFISEIMLNMSMISWPNDASRIVYCRRHLLNPAAQWANDFVQEQGILEITFDTFIQGLYQHFYKPPDINKIFNAITQLSEAKLGIERLNQRFRKIWDRMPPDFMTEKAAIMTYTRLLTKETYNIVRMHKPETLKDAMEEAYQTTALTERFFPGFELDADGDTIIGATTHLQEEYDSDYDSEDNLTQNGYVHTVRTRRSYNKPMSNHRNRRNNNPSREECIKNRLCFYCKKEGHRLNECRARKAVLTDLELESKDQQTPFIKTLPIVHYIAIPEMDNTAEKTIKIQNTKVKTLFDSGSPTSFIRRDIVELLKYEIYETPPLRFRGFVATKSAVTSEAVTIDLKINDLHITLAAYILDNMDYQLLIGNPILRRYPKILHTVLNTRESPDSLKPKTYRSETVNNVRTYSAGNRGNPRNIKLSFAPTILEATDPKSAGNRGDSRTKTLSLATTTPAAIDPLTTLDNPGSTQSTFAQFPIPEEASILEEDGKYSNVVSTIQSVEPNATDHSNKDTFCTLPVWLQQKYREIIRNDLPPRPADINNIPVKHDIEIKPGARLPRLQPYHVTEKNEQEINKIVQKLLDNKFIVPSKSPCSSPVVLVPKKDGTFRLCVDYRTLNKATISDPFPLPRIDNLLSRIGNAQIFTTLDLHSGYHQIPMEPKDRYKTAFVTPSGKYEYTVMPFGLVNAPSTFARYMADTFRDLRFVNVYLDDILIFSESPEEHWKHLDTVLERLKNENLIVKKKKCKFASEETEFLGYSIGIQKIAPLQHKCAAIRDFPTPKTVKQAQRFLGMINYYRRFIPNCSKIAQPIQLFICDKSQWTEKQDKAIDKLKDALCNSPVLVPFNNKANYRLTTDASKDGIGAVLEEVDNKNKLVGVVGYFSKSLESAQKNYPAGELELLGIIKALHHFRYMLHGKHFTLRTDHISLLSLQNKNEPARRVQRWLDDLATYDFTLEYLAGPKNVVADAISRAVYTITPETSRPIDTESWKSYYKSDPLCSAVLIHMKELTQHNVTPEDMSAFRSYQKKLELSETFRKNYSLEDEMIYYQDRLVVPIKQQNAVMRLYHDHTLFGGHFGVTVTLAKISPIYYWPKLQHSIIQYIRTCVQCQLIKSHRPRLHGLLQPLPIAEGRWLDISMDFVTGLPPTSNNLNMILVVVDRFSKRAHFIATRKTLDATQLIDLLFRYIFSYHGFPRTITSDRDVRMTADKYQELTKRLGIKSTMSSANHPQTDGQSERTIQTLNRLLRAYASTNIQNWHVYLPQIEFVYNSTPTRTLGKSPFEIDLGYLPNTPAIKSDDEVNARSFTAVELAKHLKALTIQTKEQLEHAQIEMETNNNQRRKPLLLNIGDHVLVHRDAYFKKGAYMKVQQIYVGPFRVVKKINDNAYELDLNSHKKKHRVINVQFLKKFVYRPDAYPKNKPISSTERIKRAHEVTALIGIDTTHKTYLCHMQDVDPTLSVEYSEAEFCQIPERTRRSILANFRQLYETQDNPEREEDVVSQNEICQYDNTSP
Protein: Profilin (Q8I2J4)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P07274}.
Interaction partners:
- Cofilin/actin-depolymerizing factor homolog 1
- Actin-1
Sequence:
MAEEYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEESDPNFDKWSLFYKEDYDIEVEDENGTKTTKTINEGQTILVVFNEGYAPDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGLHLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAESSQ
Protein: prephenate dehydratase (EC 4.2.1.51) (C8V9C8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Chorismate mutase
- Pentafunctional AROM polypeptide
- Multifunctional tryptophan biosynthesis protein
- Chorismate synthase
- Prephenate dehydrogenase [NADP
- histidinol-phosphate transaminase
- Tryptophan synthase
- tryptophan synthase
Sequence:
MAPFKVTFLGPAASFSHQAAVETFGRSSELIPCLSFADAIAAVQRRDADYAIVPFENSTNGSVVQTLDLLVDRNGSYNDVKVCGEYYLTVHHCLLARKGFISAARRNYSSITKIYTHPQAWGQCEIFLAKYFKGVERQDVSSTSKASETVLKTTSEVNAAIASRFAGEYYGLDILEENIEDTANNTTRFLVLRNVYSTTTIQFQPELARELSKSPAVLETKKALFSFMVRQDTLGTLADALLIFKDRGLNLTSINTRPSHIQAWKYVFLVESETDQNQEVPDIMDSLRKVTENCKHLGTWANKLVST
Protein: PomB (O06874)
Organism: Vibrio alginolyticus
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
Interaction partners:
Sequence:
MDDEDNKCDCPPPGLPLWMGTFADLMSLLMCFFVLLLSFSEMDVLKFKQIAGSMKFAFGVQNQLEVKDIPKGTSIIAQEFRPGRPEPTPIDVIMQQTMDITQQTLEFHEGESDRAGGTKRDEGKLTGGQSPATSTQNNESAEADMQQQQSKEMSQEMETLMESIKKALEREIEQGAIEVENLGQQIVIRMREKGAFPEGSAFLQPKFRPLVRQIAELVKDVPGIVRVSGHTDNRPLDSELYRSNWDLSSQRAVSVAQEMEKVRGFSHQRLRVRGMADTEPLLPNDSDDNRALNRRVEISIMQGEPLYSEEVPVIQ
Protein: Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2) (O43623)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
Subcellular location: Nucleus {ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:29910125}. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
Interaction partners:
- Lysine-specific histone demethylase 1A FAD-dependent demethylase 1A)
- Twist-related protein 1
- Cadherin-1
- Histone deacetylase 1
- Cellular tumor antigen p53
- Transcription factor SOX-9
- Cadherin-2
- Vimentin
- Paired amphipathic helix protein Sin3a
- Zinc finger protein SNAI1
Sequence:
MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYSMPVIPQPEILSSGAYSPITVWTTAAPFHAQLPNGLSPLSGYSSSLGRVSPPPPSDTSSKDHSGSESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH
Protein: Zinc finger MYND-type containing 11 (B0QZE2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MARLTKRRQADTKAIQHLWAAIEIIRNQKQIANIDRITKYMSRVHGMHPKETTRQLSLAVKDGLIVETLTVGCKGSKAGIEQEGYWLPGDEISIKKKNTNKQEMGTYLRFIVSRMKERAIDLNKKGKDNKHPMYRRLVHSAVDVPTIQEKVNEGKYRSYEEFKADAQLLLHNTVIFYGADSEQADIARMLYKDTCHEIPNHELVWAKMKGFGFWPAKVMQKEDNQVDVRFFGHHHQRAWIPSENIQDITVNIHRLHVKRSMGWKKACDELELHQRFLREGRFWKSKNEDRGEEEAESSISSTSNEQLKVTQEPRAKKGRRNQSVEPKKEEPEPETEAVSSSQEIPTMPQPIEKVSVSTQTKKLSASSPRMLHRSTQTTNDGVCQSMCHDKYTKIFNDFKDRMKSDHKRETERVVREALEKLRSEMEEEKRQAVNKAVANMQGEMDRKCKQVKEKCKEEFVEEIKKLATQHKQLISQTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQEHWHAEHKRTCRRKR
Protein: Alpha-glucosidase (EC 3.2.1.20) (Maltase) (O04931)
Organism: Beta vulgaris (Sugar beet)
Function: High activity for alpha-glucan.
Interaction partners:
Sequence:
MERSKLPRYICPTLAVVLPLVLCMVVEGATTSKNDNQGEAIGYGYQVKNAKVDNSTGKSLTALLQLIRNSPVYGPDIHFLSFTASFEEDDTLRIRFTDANNRRWEIPNEVLPRPPPPPSPPPLSSLQHLPKPIPQNQPTTTVLSHPHSDLAFTLFHTTPFGFTIYRKSTHDVLFDATPIPSNPTTFLIYKDQYLQLSSSLPAQQAHLYGLGEHTKPTFQLAHNQILTLWNADIASFNRDLNLYGSHPFYMDVRSSPMVGSTHGVFLLNSNGMDVEYTGDRITYKVIGGIIDLYIFAGRTPEMVLDQYTKLIGRPAPMPYWAFGFHQCRWGYRDVNEIETVVDKYAEARIPLEVMWTDIDYMDAFKDFTLDPVHFPLDKMQQFVTKLHRNGQRYVPILDPGINTNKSYGTFIRGMQSNVFIKRNGNPYLGSVWPGPVYYPDFLDPAARSFWVDEIKRFRDILPIDGIWIDMNEASNFITSAPTPGSTLDNPPYKINNSGGRVPINSKTIPATAMHYGNVTEYNAHNLYGFLESQATREALVRPATRGPFLLSRSTFAGSGKYTAHWTGDNAARWDDLQYSIPTMLNFGLFGMPMIGADICGFAESTTEELCCRWIQLGAFYPFSRDHSARDTTHQELYLWESVAASARTVLGLRYELLPYYYTLMYDANLRGSPIARPLSFTFPDDVATYGISSQFLIGRGIMVSPVLQPGSSIVNAYSPRGNWVSLSNYTSSVSVSAGTYVSLSAPPDHINVHIHEGNIVAMQGEAMTTQAARSTPFHLLVVMSDHVASTGELFLDNGIEMDIGGPGGKWTLVRFFAESGINNLTISSEVVNRGYAMSQRWVMDKITILGLKRRVKIKEYTVQKDAGAIKVKGLGRRTSSHNQGGFFVSVISDLRQLVGQAFKLELEFEGATR
Protein: GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) (Q96CN9)
Organism: Homo sapiens (Human)
Function: Probably involved in maintaining Golgi structure.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10209125}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- Golgin subfamily A member 4
- Trans-Golgi network integral membrane protein 2
- Bystin
- Protein AATF
- Intersectin-1
- Glutamate receptor-interacting protein 1
- RNA-binding protein NOB1
- Serine/threonine-protein kinase RIO2
- Pre-rRNA-processing protein TSR1 homolog
- Protein LTV1 homolog
Sequence:
MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEKQVIMRLPTSASWWPSGKR
Protein: Cytochrome P450, family 2, subfamily j, polypeptide 3 (A0A0G2K921)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}. Microsome membrane {ECO:0000256|ARBA:ARBA00004524}.
Interaction partners:
Sequence:
QFVKKYGNIFSLNLGDITSVVITGLPLIKETFTHIEQNILNRPLSVMQERITNKNGLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRMQEEAHYLVEAIREEKGKPFNPHFSINNAVSNIICSVTFGERFEYHDSRFQEMLRLLDEVMYLETTMISQLYNIFPWIMKYIPGSHQTVFRNWEKLKLFVSSMIDDHRKDWNPEEPRDFIDAFLKEMSKYPEKTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYAEVQEKVQAEIDRVIGQKRAASLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTTLNGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLENGQFKKRESFLPFSMGKRACLGEQLARSELFIFFTSLMQKFTFKPPTNEKLSLKFRNGLTLSPVTHRICAVPRE
Protein: Lysozyme C II (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C) (Lysozyme type II) (P11941)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has antibacterial activity against the Gram positive bacterium P.citreus. Has no antibacterial activity against the Gram negative bacteria E.coli and Y.ruckeri. Does not have hemolytic activity against trout erythrocytes.
Subcellular location: Secreted.
Interaction partners:
Sequence:
MRAVVVLLLVAVASAKVYDRCELARALKASGMDGYAGNSLPNWVCLSKWESSYNTQATNRNTDGSTDYGIFQINSRYWCDDGRTPGAKNVCGIRCSQLLTADLTVAIRCAKRVVLDPNGIGAWVAWRLHCQNQDLRSYVAGCGV
Protein: RAR-related orphan receptor C (RORC protein) (Q6I9R9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
Protein: Flagellar protein FliT (P0A1N2)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
Subcellular location: Cytoplasm, cytosol.
Interaction partners:
- Flagellar secretion chaperone FliS
- Flagellar hook-associated protein 2
- Flagellar hook-associated protein 1
- Flagellar FliJ protein
- Flagellar biosynthesis protein FlhA
- Flagellar hook-associated protein 3
- Protein FliZ
- Flagellin
- Flagellum-specific ATP synthase
- Flagella synthesis protein FlgN
Sequence:
MTSTVEFINRWQRIALLSQSLLELAQRGEWDLLLQQEVSYLQSIETVMEKQTPPGITRSIQDMVAGYIKQTLDNEQLLKGLLQQRLDELSSLIGQSTRQKSLNNAYGRLSGMLLVPDAPGAS
Protein: GATOR2 complex protein Wdr24 (EC 2.3.2.27) (WD repeat-containing protein 24) (Q9XZ25)
Organism: Drosophila melanogaster (Fruit fly)
Function: An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development. This GATOR2 component is required for activating TORC1 and promoting cell growth in both germline and somatic cells. In addition to its role in regulation of the TORC1 complex, functions independently of TORC1 to promote the acidification of lysosomes and facilitates autophagic flux.
Subcellular location: Lysosome {ECO:0000269|PubMed:27166823}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:27166823}. Note=Localizes to lysosomes and autolysosomes under fed and starved conditions (PubMed:27166823). In female egg chambers, localizes primarily to autophagosomes and autolysosomes during amino-acid starvation (PubMed:27166823). {ECO:0000269|PubMed:27166823}.
Interaction partners:
- Nucleoporin seh1
- Protein SEC13 homolog
- GATOR2 complex protein Mio
- GATOR complex protein NPRL3
- GATOR complex protein Iml1
- GATOR complex protein NPRL2
- GATOR2 complex protein Wdr59
- GH04846p
- GH16429p
- FI04419p
Sequence:
MPDSVEDTSTISLRICLEGHANALALNKDNNQIALAGRSLLKVYSINSNGFTESCNMRGKNQNLSYSANDVAWSTLDSNLLATAATNGVVSVWDLSKFGRQKQLLVYNEHERTAHTVTFHSSEPNILISGSQDGTIKCFDIRSDKSINTYFCNSESVRDVKFSPHTQNIFSAVSENGTVQLWDMRKWDKCMVQFTAHYGPVYTCDWHPTRNWLATGSRDKQIKVWNMDGRPGLEHTIHTIAVVGRVKWRPERTYHIASCALVVDYSVHVWDIRRPYIPFASFNEHTNVTTGIAWQGSDSHCLLSISKDSTIYKHAFKDATRPALKANAQGASLGRFGDISFANKIKEYEPKTSGASNTKSSSFIRRKTNVAGSIQFHLDHSKMYKFMVNDTFSGYPLSESVSRPTQEHESFIGCARELVISGKKLSELCEHNAEVSKKYGKHNATTLWNFIKLFYGSNHFEPPFEHRSSFSNQKNPMNSRRATQVASDWPQQRTELGQDLNGNTPETAHEIDVANVDDDTLGSSGVEHPPTSSVILSETQIISEITFDNFELLRNGFIYVGPTECPKALAFPALHHDVQAARPQLDLKASDHEKSPPPHVPTVLKVSHVPPIPMWEPHKFVSDALMLMNDVGDVQTALTVLIALGEARKLLPIDDALVEHWFYTYVDQLHRYELWNEACEVINRSWLRSVQQLNQHSTAMHTNCGECGRPMGGKVGWYCDKCKSMQSAKCCVCGLIVRGVYAWCQGCSHGGHIEHLQKYFAKHSKCPKCGHLCAYS
Protein: HCG2001421 (cDNA FLJ75904) (A8K0U2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MCHPEASRPFSPWYPPPRSCLPKPSSCCCSHNKCHHQGPSSCQCRLSRAGDWGTCSHHLSNSGGSQASQGSDDDRNEKWDDSSTLVDELRTPGRGMYLVFDGSVDLHYHCSAKCKS
Protein: Protein lin-9 (Abnormal cell lineage protein 9) (P30630)
Organism: Caenorhabditis elegans
Function: Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. Required for the development of sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad. In association with the zinc finger protein ztf-11, negatively regulates the expression of non-neuronal genes during neurogenesis.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Protein lin-52
- Protein lin-54
- Probable histone-binding protein lin-53
- Retinoblastoma-like protein homolog lin-35
- Uncharacterized protein
- E2F/DP family winged-helix DNA-binding domain-containing protein
- Transcription factor dpl-1
- Probable histone-binding protein rba-1
- ETS domain-containing protein
- Protein let-418
Sequence:
MSSAVRSPRKKAASDTSDPDRTSSPYSLRETSKVPSRYRNEELYLSPSRSIKRTGSPKKSPAKRLNGGRDSPSVNSLTRNSSLTMLAKAALDYESSSCALEYIFQPKEERRPPRRALALSPPPAPSNDLLAKDLEMIEMHQNLVAGLDDLDNPANMTNEAVEHRDTQSFFNMFSTDQERSAMMKQFKTYKNQTSEDVSTFMRANIKKLYNLLRYKKARQWVMCEFFYSAIDEQIFKEENEFATIIRESFPNLKNWNLTRIEWRSIRKLLGKPRRCSKVFFEEERMYLEEKRMKIRSVYEGSYLNDPSIDLKDLPAKLPRPMVVGNRVFARIRNPYDGIYSGIIDAVIPKGFRIIFDKPDIPPTLVSDTEILLDGKLDLLSIAYFIEQANSKLPSGVRPFVAAVRDSSHPHLVRDVLVSRKIERSGGPLMGPNDERLNGKNAEMVGNFPLKFLVNLVKLTKLIDIKKGLIRQLNELNADAEIQNMTSDKYSKAFQEKYAKTIIDLEHVNQNIDINMNGIQDHHMYFSSNDISTSNMKPEAVRQMCSQQAGRFVEHCNQGLNVENVHALTLIQSLTAVLLQVRTMGTQKISAVDLQSLGDAISEIRTAIHPRNVAFFQDYVEVHMKQFHTIMLESGALAGTVSNRK