wanglab/gogpt-training-data huggingface dataset:
Protein: E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (P0CH30)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Promotes polyubiquitination of target proteins.
Interaction partners:
Sequence:
MSSDGNVTGGGGANTVGVTNKPFFCYQCNRTVNVTISPPSSDPTCPICNEGFLEEYDNPNPNQGSGFLNPNPNSIPFHDLFLTLSDPFASLLPLLFPSSSSTTTSSSASIDPNNPSLSGPTRSGRGDPFAFDPFTFIQNHLNDLRSSGAQIEFVIQNNPSDQGFRLPANIGDYFIGPGLEQLIQQLAENDPNRYGTPPASKSAIEALPLVNITKSNLNSEFNQCAVCMDDFEEGTEAKQMPCKHLYHKDCLLPWLELHNSCPVCRHELPTDDPDYERRVRGAQGTSGGNDGDNSGQRSDGDNRTVERSFRISLPWPFQARGPGPAPGDNAETRQEDLD
Protein: Sugar transporter SemiSWEET (B0SR19)
Organism: Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Function: The homodimer mediates transmembrane sugar transport down a concentration gradient. Transport is probably effected by rocking-type movements, where a cargo-binding cavity opens first on one and then on the other side of the membrane.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25186729}; Multi-pass membrane protein {ECO:0000269|PubMed:25186729}.
Interaction partners:
- NADPH-dependent 7-cyano-7-deazaguanine reductase
- Putative ferredoxin
- GMP synthase
Sequence:
MENLIGYVAAFLTTVSFLPQVLRVVMTKQTRDISRNMYIMFFLGVVLWFVYGILRSDLPIILANVVTLFFVTIILYYKLTEGNQT
Protein: p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84) (Q9NWT1)
Organism: Homo sapiens (Human)
Function: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Interaction partners:
- Probable ribosome biogenesis protein RLP24
- Ribosome production factor 2 homolog
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Probable rRNA-processing protein EBP2
- mRNA turnover protein 4 homolog
- Ribosome biogenesis protein BRX1 homolog
- Nucleolar GTP-binding protein 2
- RRP15-like protein
- GTP-binding protein 4
- Protein MAK16 homolog
Sequence:
MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ
Protein: Late embryogenesis abundant protein 49 (LEA 49) (Q9FK15)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: LEA proteins are late embryonic proteins abundant in higher plant seed embryos. The function of those proteins is not known.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25005920}. Nucleus {ECO:0000269|PubMed:25005920}.
Interaction partners:
- Protein SENESCENCE-ASSOCIATED GENE 21, mitochondrial
Sequence:
MGSSKDSASVTNISVEEHFSVSQSSPGGQFVGPTEEISTAAEALIGRSTTLTEALKAASMNVGHKPVETTDVAAIKEVETRAIGGDIESEGGVTAVASKAVARNQKIGKDNEKTNLGDVIAEIDVKVTRDREVTSEDAEAVIRAELNHSPFNNIIPGGVAESVAAAYKLNHDPSSL
Protein: Interleukin 17_5 (Interleukin 17a/f3) (Q5TKT0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
- Interleukin 17 receptor C.
- Interleukin 17 receptor A1a
- Interleukin 17 receptor A1b.
- Interleukin 17_1
- Interleukin family protein
- Interleukin-22
- Interleukin 13
- Forkhead box P3
- Lymphotoxin-alpha
- Interleukin-6
Sequence:
MRLSRVFRAVLLLFLLMLLLDAALSENRTKRKRCSGVKKCTSAGCKSRCQRKTAWVILNSAWDNIMSDTPSPDRSLSPWTYTTSVDESRIPSTISEAKCEKRGCLTKDGEEDLGLESQPIYYQINILRRVKKKNSTFYALKLETKKVSVGCTCVLPIVLPQN
Protein: Complement factor H (G3V9R2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Complement factor I
- Complement C3
- Complement factor B
- Mannose-binding protein C
- Complement C4
- Thrombomodulin
- Mannan-binding lectin serine protease 1
- Mannan-binding lectin serine protease 2
- Ficolin-1
- Ficolin-2
Sequence:
MRLSARIIWLILWTVCVAEDCKGPPPRENSEILSGSWSEQLYSEGTQATYKCRPGYRTLGTIVKVCKNGEWVPSNPSRICRKRPCGHPGDTPFGSFRLAVGSEFEFGAKVVYTCDEGYQLLGEIDYRECDADGWTNDIPICEVVKCLPVTELENGRIVSGAAEPDQEYYFGQVVRFECNSGFKIEGQKEMHCSENGLWSNEKPQCVEISCLPPRVENGDGIYLKPVYKENERFQYKCKQGFVYKERGDAVCTGSGWNPQPSCEEMTCLTPYIPNGIYTPHRIKHRIDDEIRYECKNGFYPATRSPVSKCTITGWIPAPRCSLKPCDFPQFKHGRLYYEESRRPYFPVPIGKEYSYYCDNGFTTPSQSYWDYLRCTVNGWEPEVPCLRQCIFHYVEYGESLYWQRRYIEGQSAKVQCHSGYSLPNGQDTILCTENGWSPPPKCVRIKTCSVSDIEIENGFFSESDYTYALNRKTRYRCKQGYVTNTGEISGIITCLQDGWSPRPSCIKSCDMPVFENAMTKNNNTWFKLNDKLDYECHIGYENEYKHTKGSITCTYDGWSSTPSCYERECSIPLLHQDLVVFPREVKYKVGDSLSFSCRSGHRVGADLVQCYHFGWSPNFPTCEGQVKSCDQPLEIPNGEIKGTKKVEYSHGDVVEYDCKPRFLLKGPNKIQCVDGKWTTLPICVEYERTCGDLPALEHGSVQLSVPPYHHGDSVEFTCAETFTMIGHAVVFCISGRWTELPQCVATDQLEKCKAPKSTGIDAIHPNKNEFNHNFSVSYRCRQKQEYEHSICINGRWDPEPNCTRNEKRFCPPPPQIPNAQVIETTVKYLDGEKVSVLCQDGYLTQGPEEMVCKHGRWQSLPRCTEKIPCSQPPKIEHGSIKSPRSSEERDLIESSSYEHGTTFSYVCDDGFRISEENRVTCNMGKWSSLPRCVGIPCGPPPSIPLGIVSHELESYQYGEEVTYNCSEGFGIDGPAFIKCVGGQWSEPPKCIKTDCDNLPTFEIAKPTEKKKKSYRSGEQVTFRCPPPYRMDGSDIVTCVNTKWIGQPVCKDNSCVNPPHVPNATILTRHKTKYPSGDKVRYDCNKPFELFGEVEVMCQNGIWTEPPKCKDSTGKCGPPPPIDNGDITSLSLPVYAPLSSVEYQCQNYYLLKGNKIVTCRNGKWSQPPTCLHACVIPEDIMEKHNIVLRWRENAKIYSQSGENIEFMCKPGYRKFRGSPPFRTKCIEGHINYPTCV
Protein: Gamma-sarcoglycan (Gamma-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) (P82348)
Organism: Mus musculus (Mouse)
Function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular location: Cell membrane, sarcolemma {ECO:0000269|PubMed:9864373}; Single-pass type II membrane protein {ECO:0000269|PubMed:9864373}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9864373}.
Interaction partners:
- Alpha-sarcoglycan
- Dystroglycan 1
- Beta-sarcoglycan
- Dystrophin
- Delta-sarcoglycan
- Dystrobrevin alpha
- Utrophin
- Sarcospan
- Epsilon-sarcoglycan
- Caveolin-3
Sequence:
MVREQYTTVTEGTHIERPENQHIYKIGIYGWRKRCLYLFVLLLLAILVVNLALTIWILKVMWFSPIGMGHLHVTADGLRLEGESEFLFPLYAKEIRSRVDSSLLLQSTQNVTVSARNSEGEVTGRVKVGAQMVEVQSQHFQINSEDGKPLFSAEEQDVVVGTGRLRVTGPEGALFEHSVETPLVRADPFQDLRLESPTRSLSMDAPRGVHVKANAGKLEALSQMDIILQSSEGVLVLDAETVGLTKLKQGTQGPAGSSNGFYEICACPDGKLYLSMAGEVTTCEEHSHVCL
Protein: Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (Cytochrome c oxidase subunit IV isoform 2) (COX IV-2) (Q96KJ9)
Organism: Homo sapiens (Human)
Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00423}; Single-pass membrane protein {ECO:0000250|UniProtKB:P00423}.
Interaction partners:
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 6A1, mitochondrial
- Cytochrome c oxidase subunit 5B, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome c oxidase subunit 7C, mitochondrial
- Cytochrome c oxidase subunit 6A2, mitochondrial
- Cytochrome b-c1 complex subunit 6, mitochondrial
Sequence:
MLPRAAWSLVLRKGGGGRRGMHSSEGTTRGGGKMSPYTNCYAQRYYPMPEEPFCTELNAEEQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVIWWQRVYVFPPKPITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK
Protein: Apocytochrome c1 (O97134)
Organism: Trypanosoma brucei
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MAGKKAHPIKRDWYWNHNDRFEIWHSLDWPSVRRGRQIYTEVFAPCHPLGRMTFTHFQGFMTREEIKQLASQYEVVDSAPDAQGMLNPRPGKPTDTLPIPFPNQRAAQFANNGSEPPDLQHSVFGKEGGPDYIFSLITGYNWGNGELMEIPPFAPELKPGQFWNPYFKDCVLSMPPPLSDGMVDYEDGTPATISQMAKDVVNFLRWSAESEYDDRRVMFWKCFTTLGLVNCILLHYCQKNTNWRIYGRTTFRYWKKTW
Protein: Cell division control protein 12 (Q10059)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends.
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889}. Note=Nuclear, and septum.
Interaction partners:
- Cell division control protein 15
- Myosin type-2 heavy chain 1
- Actin
- Anillin-related medial ring protein mid1
- Ras GTPase-activating-like protein rng2
- Profilin
- Cell division control protein 42 homolog
- Formin-3
- GTP-binding protein rho1
- Myosin regulatory light chain 1
Sequence:
MRNSSKGQDPNFSYDSILSTPTPSARRTIGPRAPKSKTTYHKPPSSIESVSTLIQPNKSQSVTSPYVKQFTFSSKEYNSHNKHALQNSQLPLPKTPEKSTVHRPKANKVEVTDLPSSSSVEHLHTSKHLKGPRLPKNIIKSSEDVQIAPVTPPVHSRSFDPLPKPPVPSVPVSKTKRRTKHKLAPVVEVPEITNEVSPKFTSTNDEQVYRLRSIRAGSPNSVCSFQFEIPSTRPPSLDQLIHLFNDFLRHPVFDFDENAIEMLQSCTPDEKWCFIRSNFAGFDDPSFQIPELAAVHRPVSWFVIQLWNKTISNLQLITLSSLLSTQSDRWISLFLELQGLRALHNLLTYFNSSAVVQPQQAEVPRCMLTLLKKKPTLVTSNSYIFQAITVTLISPNLLPRKVAADLLTWVLSLKEPLVVSILETGFKEINAEYEKEVPLFFGWIKSFKDIILEKELARTPPSSPARNSASSSPSNIAFLEYCTSTMEFINQLIVACEELEQGFDLDILDSLRESGIHEVIQLLRNFPDQQLEKQLNIYESEEERRTISQTTHEDVDSFMSNESSILSSFNEFASNEVGRLLESTIQNILLAKGTEKQKVKLIKVFNSLLQRILLNSKVSNESFEDSLQASLNMLTERFYSDDTARNALKEAKASRAMAEKMVIERDAMAAQVNLGAEDLIAKLNKEVEDQKDVILSQKRTNETLKTEIDALQKSHVTQIQRSEVELRELYLLINSDSFQGSTNSKERIIEYLLDKLDLRKKEIAAESTLWSNDGIDDKLRDLREQMSRQSSQPSTVSTILQIPDKKFHRPFPRHLHRYVGRSASESLTSEKDESIKSMKGIDDFANLEIPGKGIESNVVIKDISNQTHEINSVENKAETVSNNSKITNFDIPNDATSLPTIITHPTPPPPPPLPVKTSLNTFSHPDSVNIVANDTSVAGVMPAFPPPPPPPPPLVSAAGGKFVSPAVSNNISKDDLHKTTGLTRRPTRRLKQMHWEKLNSGLEFTFWTGPSDEANKILETLHTSGVLDELDESFAMKEAKTLVKKTCARTDYMSSELQKLFGIHFHKLSHKNPNEIIRMILHCDDSMNECVEFLSSDKVLNQPKLKADLEPYRIDWANGGDLVNSEKDASELSRWDYLYVRLIVDLGGYWNQRMNALKVKNIIETNYENLVRQTKLIGRAALELRDSKVFKGLLYLILYLGNYMNDYVRQAKGFAIGSLQRLPLIKNANNTKSLLHILDITIRKHFPQFDNFSPELSTVTEAAKLNIEAIEQECSELIRGCQNLQIDCDSGALSDPTVFHPDDKILSVILPWLMEGTKKMDFLKEHLRTMNTTLNNAMRYFGEQPNDPNSKNLFFKRVDSFIIDYSKARSDNLKSEEEEASQHRRLNLVNNHKEHVLERAMSENNKMDNEAMDGFLDKLRNVKLESHHKPRNRSAITMGKEHLIEAPNTSTKSSPAKNELFVPKRSSVKSDLAKVRPRYPKGSESTDGLSDALNITPTKKGEVSSKAKKGYNYEKRRSGRQVSDSYVLNKNSKNKSNKGRSASYTFSDPSSLEDSNRQKPFNGEKFRRFSSKSRRGSQNRDSKKTGKARKDKGINNNQTSPQNKPSKESLKSDTISNEKKVFPQKASKVNLLTPTISNGTRASKHANEKENTFPRGVENNLVAPMIPNNTELNEDTSAVSRNLENATNDLKETFPTTTTISTARAKPGNNDINTILRRNNSRGRRRMLQQMSPLKSNKFSGTNDLNFQQATKPDGSNKSSYMERLEKLKQNSERHLQSVGGKKVYSSEETPVNKILVSPSVSILDHNRILSQSTPIKSPQRAQEMLAGLLSGKLAPKENEK
Protein: GH11189p (Neuropilin and tolloid-like, isoform A) (Q9VYC7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRRRGSTCSAQQPQQRPHKQQQQQQQQNQRLIPGQRCSLLMLLIVGQAVYASAGSEIIANRSASAGESLIMLSNFTVATPPPAPRFTSPFREQDVAEGEELAGGGQVDWLDEQHPLTISRPPRAGRSERQAEEDQVDRCRLFVEGDPTKNELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFRNSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPEITSKERYLWLHFHSDETIEYTGFSAVYEYLDRSRDAPSTDLNCTIDKGGFEGFINSTDVPAEIWEQVNRNKIALDCIWRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDIFPEQTVMPLRVKNFCGSAGESITAESNILHLRFYADQTAINSTFGILFTAFRERGAACTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGCTSEAAGQSEHVVIIVIVFGLILGGMVITFIVNCIRKIIRDQKIIRDVPALSDGIYHIDSFILEAPKSAIFVGLQNDFMCDFSYSSDGQMAPNLGHETRDEEAAVGGDSDFDSQMDSPKQTCDCDFELDVNDGEQMEEDDEEELEEEQEQDHHVEDQEYDDGIGFSCDSDSGLTLPEDDDEFVLVTGQCLPSNSSHSCSSSMQCSSGSSGREVATSSSNSMELDMVLTPPPPPTLGKPKSGVHPLKFLHKII
Protein: S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1) (Q71U00)
Organism: Xenopus laevis (African clawed frog)
Function: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).
Interaction partners:
Sequence:
MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK
Protein: Homeobox-leucine zipper protein MERISTEM L1 (HD-ZIP protein ATML1) (Homeodomain transcription factor ATML1) (Q8RWU4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor involved in cell specification and pattern formation during embryogenesis. Binds to the L1 box DNA sequence 5'-TAAATG[CT]A-3'. Plays a role in maintaining the identity of L1 cells, possibly by interacting with their L1 box or other target-gene promoters; binds to the LIP1 gene promoter and stimulates its expression upon imbibition. Acts as a positive regulator of gibberellins (GAs)-regulated epidermal gene expression (e.g. LIP1, LIP2, LTP1, FDH and PDF1). Functionally redundant to PDF2. Seems to promote cell differentiation.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Calpain-type cysteine protease DEK1
- Protein CLAVATA 3
- Serine/threonine-protein kinase-like protein ACR4
- Homeobox-leucine zipper protein ATHB-5
- Axial regulator YABBY 1
- Protein WUSCHEL
- WUSCHEL-related homeobox 2
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
- WUSCHEL-related homeobox 8
- Protodermal factor 1
Sequence:
MYHPNMFESHHHMFDMTPKNSENDLGITGSHEEDFETKSGAEVTMENPLEEELQDPNQRPNKKKRYHRHTQRQIQELESFFKECPHPDDKQRKELSRELSLEPLQVKFWFQNKRTQMKAQHERHENQILKSENDKLRAENNRYKDALSNATCPNCGGPAAIGEMSFDEQHLRIENARLREEIDRISAIAAKYVGKPLMANSSSFPQLSSSHHIPSRSLDLEVGNFGNNNNSHTGFVGEMFGSSDILRSVSIPSEADKPMIVELAVAAMEELVRMAQTGDPLWVSSDNSVEILNEEEYFRTFPRGIGPKPIGLRSEASRESTVVIMNHINLIEILMDVNQWSSVFCGIVSRALTLEVLSTGVAGNYNGALQVMTAEFQVPSPLVPTRENYFVRYCKQHSDGIWAVVDVSLDSLRPSPITRSRRRPSGCLIQELQNGYSKVTWVEHIEVDDRSVHNMYKPLVNTGLAFGAKRWVATLDRQCERLASSMASNIPACDLSVITSPEGRKSMLKLAERMVMSFCTGVGASTAHAWTTLSTTGSDDVRVMTRKSMDDPGRPPGIVLSAATSFWIPVAPKRVFDFLRDENSRSEWDILSNGGLVQEMAHIANGRDPGNSVSLLRVNSGNSGQSNMLILQESCTDASGSYVIYAPVDIIAMNVVLSGGDPDYVALLPSGFAILPDGSARGGGGSANASAGAGVEGGGEGNNLEVVTTTGSCGGSLLTVAFQILVDSVPTAKLSLGSVATVNSLIKCTVERIKAALACDGA
Protein: Probable para-aminobenzoate synthase component I PABD (O05591)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Anthranilate synthase component 2
- Anthranilate phosphoribosyltransferase
- Bifunctional aminodeoxychorismate lyase / D-amino acid transaminase
- Indole-3-glycerol phosphate synthase
- Chorismate synthase
- Tryptophan synthase alpha chain
- Tryptophan synthase beta chain
- Anthranilate synthase component 1
- Intracellular chorismate mutase
- Secreted chorismate mutase
Sequence:
MNLAWELSTRTKSPRSHLRCENPQFCQARTVRIDRLGDLGGAPAVLRAVGRATSRLDLPPPAALTGEWFGALAVIAPSVSIQPVSGDDVFSGPPGTGGPDATGAVGGGWVGYLSYPDAGADGRPHRIPEAAGGWTDCVLRRDRDGQWWYESLSGAPIADWLASALATTRASVARPAPACRIDWEPADRAAHRDGVLACLEAIGAGEVYQACVCTQFAGTVTGSPLDFFIDGFGRTAPSRSAFVAGPWGAVASLSPELFLRRRGSVVTSSPIKGTLPLDAPPSALRASAKEVAENIMIVDLVRNDLGRVAVTGTVTVPELLVVRPAPGVWHLVSTVSARVPLEEPMSALLDAAFPPASVTGTPKLRARQLISQWERYRRGIYCGTVGLASPVAGCELNVAIRTVEFDTAGNAVLGVGGGITADSDPDAEWAECLHKAAPIVGLPAATRTTPARLASKVR
Protein: Protein phosphatase 1 regulatory subunit SDS22 homolog (P45969)
Organism: Caenorhabditis elegans
Function: Regulatory subunit of protein phosphatase 1.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-beta
- ELRR ONly
- Protein phosphatase inhibitor 2
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase
- Serine/threonine-protein kinase plk-1
- Serine/threonine-protein phosphatase PP1-alpha
Sequence:
MSNDKSAEVVVLPRENDEESKEPVLKNQFDLSTFDIDSPEIDLTHTRADHIPDLTGFPKIEELRMRNNLLVSISPTISSLVTLTSLDLYENQLTEISHLESLVNLVSLDLSYNRIRQINGLDKLTKLETLYLVSNKIEKIENLEALTQLKLLELGDNRIKKIENIGHLVNLDELFIGKNKIRQLEGVETLQKLSVLSLPGNRIVKIENVEQLNNLKELYLSDQGLQDIHGVEPLTNLLLLDVANNEIKTFSGVERLESLNDFWANDNKVESFSEIEQLSKLKGLQTVYLERNPFYFNDTNQYRRKVMMTLTQVTQIDATTCRKPIE
Protein: Protein BTG1 (B-cell translocation gene 1 protein) (Q6IBC8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MHPFYTRAATMIGEIAAAVSFISKFLRTKGLTSERQLQTFSQSLQELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFRLLPSELTLWVDPYEVSYRIGEDGSICVLYEASPAGGSTQNSTNVQMVDSRISCKEELLLGRTSPSKNYNMMTVSG
Protein: Ig-like domain-containing protein (Q9U3F0)
Organism: Caenorhabditis elegans
Interaction partners:
- CABIT domain-containing protein
- Cilia- and flagella-associated protein 157
- Protein CASP
- RILP-like protein 1
- Ectopic P granules protein 2
Sequence:
MSVSSEISASKLPYVRIPGSKPVPRLLKWTIFKCSFMKIRTIGLHHPDGRLYFFEFCQGKDTFVPHVCSACLPIITEKDLFPDYIVWAEEIEDYVIFAFSSMSNKMEQFVYSFETRRFVEVDLPELVYNRGDATTGDIVAALYGENETIVIERDENGAMLIRSFVHKDNSRKPVNTLVMQNIEKNGLQVGKDEEVTDISNEFGYLDYVETLPELKIKTCSANRTSIHVFSKKTGRYLKYHYVINTGSFINTSNLDCSNCNSVTSEKYLLPEYSVYSKALDARVIHCTNNLTSDIEQYTFNPDTNAFEQVYCKELVYDPNRFNRASLAAYVFPENVANNGTVIISRDVYEVIQKEKYSIVTDEYVVLPAAPVKTFAVRIQEEKQKKLDEEEQQKVLKTQELEKQKDGQIVIMELEMKEMTTLLEEKDTRIKMHVEKHRDKECELELVRRKLDDCVVRMQGAFERDIKLEEAKVQASREAKKQYENLMTILGEKE
Protein: Disintegrin and metalloproteinase domain-containing protein 2 (ADAM 2) (Cancer/testis antigen 15) (CT15) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta) (Q99965)
Organism: Homo sapiens (Human)
Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Calmegin
- Disintegrin and metalloproteinase domain-containing protein 20
- Disintegrin and metalloproteinase domain-containing protein 21
- Disintegrin and metalloproteinase domain-containing protein 30
- Hyaluronidase PH-20
- CD9 antigen
Sequence:
MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG
Protein: Nucleoside diphosphate kinase (EC 2.7.4.6) (Q32Q12)
Organism: Homo sapiens (Human)
Interaction partners:
- Nucleoside diphosphate kinase B
- Nucleoside diphosphate kinase A
- Nucleoside diphosphate kinase, mitochondrial
- Nucleoside diphosphate kinase 3
- Inosine triphosphate pyrophosphatase
- Guanosine-3',5'-bis
- Cancer-related nucleoside-triphosphatase
- Thymidylate kinase
- CTP synthase 1
- CTP synthase 2
Sequence:
MVLLSTLGIVFQGEGPPISSCDTGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE
Protein: DNA damage response protein C (Q9RYE6)
Organism: Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
Function: Appears to contribute to D.radiodurans capacity to survive exposure to ionizing radiation. Likely functions as a DNA damage-induced nucleoid-associated protein (NAP) that contributes to the enhanced level of nucleoid compaction after irradiation by bridging DNA duplexes, thereby limiting the dispersion of the fragmented genome immediately after irradiation to facilitate subsequent DNA repair. In vitro, binds both ssDNA and dsDNA, and is able to compact circular DNA, circularize linear DNA, anneal complementary DNA strands and protect DNA from nucleases.
Subcellular location: Cytoplasm, nucleoid. Note=Is distributed all over the nucleoid shortly after irradiation, but after 2-3 hours, it forms discrete foci located at the sites of septal closure in between the newly segregated chromosomes of D.radiodurans. {ECO:0000269|PubMed:28542368}.
Interaction partners:
- DNA damage response protein D
- Single-stranded DNA-binding protein DdrA
- Single-stranded DNA-binding protein DdrB
- DNA repair protein PprA
Sequence:
MKNAPLTLNFGSVRLPVSADGLLHAPTAQQQLGLTQSWEAALVEHGLPETYRDFGAGPEAAVSVPDFVALAFALDTPEARRWQKRARELLARAMQGDVRVAAQIAERNPEPDARRWLAARLESTGARRELLATVARHGGEGRVYGQLGSISNRTVLGKDSASVRQERGVKATRDGLTSAELLRLAYIDTVTARAIQESEARGNAAILTLHEQVARSERQSWERAGQVQRVG
Protein: Solute carrier family 4 (anion exchanger), member 1, adaptor protein (A0A0J9YU76)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XEHEERVEDGGVRLLQEPELELEAAVEHPSAPSEPSCSKETKSHESISQLSQVEQSKDYQEMGKIVSSCEDPSAPANEYKQDRDEPKKKKSPGPGKFPPILSSKYPEDDPDYCIWVPPEGQSGDGRTHLNDKYGY
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (F4JNY4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MGLCFSSPKATRRGTGSRNPNPDSPTQGKASEKVSNKNKKNTKKIQLRHQGGIPYGKRIDFGYAKDFDNRYTIGKLLGHGQFGFTYVATDNNNGNRVAVKRIDKAKMTQPIEVEDVKREVKILQALGGHENVVGFHNAFEDKTYIYIVMELCDGGELLDRILAKKDSRYTEKDAAVVVRQMLKVAAECHLRGLVHRDMKPENFLFKSTEEGSSLKATDFGLSDFIKPGVKFQDIVGSAYYVAPEVLKRRSGPESDVWSIGVITYILLCGRRPFWDKTQDGIFNEVMRKKPDFREVPWPTISNGAKDFVKKLLVKEPRARLTAAQALSHSWVKEGGEASEVPIDISVLNNMRQFVKFSRLKQIALRALAKTINEDELDDLRDQFDAIDIDKNGSISLEEMRQALAKDVPWKLKDARVAEILQANDSNTDGLVDFTEFVVAALHVNQLEEHDSEKWQQRSRAAFDKFDIDGDGFITPEELRLQTGLKGSIEPLLEEADVDEDGRISINEFRRLLRSASLKSKNVKSPPGTEHIICHNLLDGICIEDTEERTSAVRFEYVSQVL