wanglab/gogpt-training-data huggingface dataset:
Protein: Potassium channel toxin alpha-KTx 24.1 (Potassium channel-blocking toxin 5) (Pi5) (C0HKB2)
Organism: Pandinus imperator (Emperor scorpion)
Function: Reversibly blocks voltage-gated potassium channels Kv1.2/KCNA2, Kv1.3/KCNA3 and, weakly, Shaker B.
Subcellular location: Secreted {ECO:0000269|PubMed:28502745}.
Interaction partners:
Sequence:
VAKCSTSECGHACQQAGCRNSGCRYGSCICVGC
Protein: Subtilisin-like protease SBT1.4 (EC 3.4.21.-) (Subtilase subfamily 1 member 4) (AtSBT1.4) (Q9LVJ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q84WS0}.
Interaction partners:
- QWRF motif-containing protein 2
- Tripeptidyl-peptidase 2
- Alpha/beta-Hydrolases superfamily protein
- Phytosulfokines 1
- T-complex protein 1 subunit gamma
Sequence:
MAKLSLSSIFFVFPLLLCFFSPSSSSSDGLESYIVHVQRSHKPSLFSSHNNWHVSLLRSLPSSPQPATLLYSYSRAVHGFSARLSPIQTAALRRHPSVISVIPDQAREIHTTHTPAFLGFSQNSGLWSNSNYGEDVIVGVLDTGIWPEHPSFSDSGLGPIPSTWKGECEIGPDFPASSCNRKLIGARAFYRGYLTQRNGTKKHAAKESRSPRDTEGHGTHTASTAAGSVVANASLYQYARGTATGMASKARIAAYKICWTGGCYDSDILAAMDQAVADGVHVISLSVGASGSAPEYHTDSIAIGAFGATRHGIVVSCSAGNSGPNPETATNIAPWILTVGASTVDREFAANAITGDGKVFTGTSLYAGESLPDSQLSLVYSGDCGSRLCYPGKLNSSLVEGKIVLCDRGGNARVEKGSAVKLAGGAGMILANTAESGEELTADSHLVPATMVGAKAGDQIRDYIKTSDSPTAKISFLGTLIGPSPPSPRVAAFSSRGPNHLTPVILKPDVIAPGVNILAGWTGMVGPTDLDIDPRRVQFNIISGTSMSCPHVSGLAALLRKAHPDWSPAAIKSALVTTAYDVENSGEPIEDLATGKSSNSFIHGAGHVDPNKALNPGLVYDIEVKEYVAFLCAVGYEFPGILVFLQDPTLYDACETSKLRTAGDLNYPSFSVVFASTGEVVKYKRVVKNVGSNVDAVYEVGVKSPANVEIDVSPSKLAFSKEKSVLEYEVTFKSVVLGGGVGSVPGHEFGSIEWTDGEHVVKSPVAVQWGQGSVQSF
Protein: ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Mvh) (Vasa homolog) (Q61496)
Organism: Mus musculus (Mouse)
Function: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20439430, ECO:0000269|PubMed:22900038}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22900038}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000269|PubMed:20439430}.
Interaction partners:
- Piwi-like protein 2
- Tudor domain-containing protein 1
- RNA helicase Mov10l1
- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
- Deleted in azoospermia-like
- Putative ATP-dependent RNA helicase TDRD12
- Ran-binding protein 9
- Piwi-like protein 1
- Synaptonemal complex protein 3
- Protein maelstrom homolog
Sequence:
MGDEDWEAEILKPHVSSYVPVFEKDKYSSGANGDTFNRTSASSDIGESSKKENTSTTGGFGRGKGFGNRGFLNNKFEEGDSSGFWKESNNDCEDNQTRSRGFSKRGGCQDGNDSEASGPFRRGGRGSFRGCRGGFGLGRPNSESDQDQGTQRGGGLFGSRKPAASDSGNGDTYQSRSGSGRGGYKGLNEEVVTGSGKNSWKSETEGGESSDSQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIVLAGRDLMACAQTGSGKTAAFLLPILAHMMRDGITASRFKELQEPECIIVAPTRELINQIYLEARKFSFGTCVRAVVIYGGTQFGHSVRQIVQGCNILCATPGRLMDIIGKEKIGLKQVKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLLFSATFPEEIQRLAGDFLKSSYLFVAVGQVGGACRDVQQTILQVGQYSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRCGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDTDSDNHLAQPLVKVLSDAQQDVPAWLEEIAFSTYVPPSFSSSTRGGAVFASVDTRKNYQGKHTLNTAGISSSQAPNPVDDESWD
Protein: Putative D-lactate dehydrogenase C713.03, mitochondrial (EC 1.1.2.4) (Q9C1X2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable hydroxyacylglutathione hydrolase SPCC13B11.03c
- Probable hydroxyacylglutathione hydrolase glo2
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- NAD-dependent malic enzyme
- NAD-dependent malic enzyme
- Probable L-lactate dehydrogenase
- 2-hydroxyacid dehydrogenase homolog 2
- Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
- Probable glutathione-independent glyoxalase hsp3104
- Pyruvate carboxylase
Sequence:
MHSLQCRRVIPFGKLSLSLHAPRNALRFVHKPAFTFESYKSLHRDPKYAKLSEQDVQVFKSIIGKDGSLIDGLDKSTDPADLDAFNIDWMNKYRGKTQLALKPKTTQQVSEILKYCNQKKLAVVPQGGNTGLVGGSVPVFDEIVLNLGLMNQIHTFDEISGVITLDSGVILENADNFLAEKGYMFPLDLGAKGSCQVGGCAATAAGGLRLLRYGSLHGSILGMEAVLPDGTILDNLVTLRKDNTGLDIKQLFIGSEGYLGVITKLSVICPKRPSSTNVAFFGVPSYENVLKAFSETRSHLTEILSAFELMDNTSQTLVDKYSGTQRPLEDEHPFYVLVETQGSNKEHDEQKITALVEDLLEKEIISDGVLAQDESQLRVLWERREGITECLAKAGSGVYKYDVSLPLPVLYDLVNDTKKRLIEFNLLDDTPEHPVIDVVGFGHMGDGNLHLNIAVRQFDKRVEKCLEPWVYEWVSRHRGSISAEHGLGLLKKPFVGYSKSKEMIHLMKTLKNVFDPNGIMLPYKYV
Protein: Rifin (Q8I210)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
Sequence:
MKVHYINILLFALPLNILVINQRNHNNSTYHTSNTKLTKTHRTLCECELYAPSNYENDPEMKELMENFNHQSSERFREYDERIQDKRKQFKEQCEKDIQKIILKDKIEKELTEKLSTLQTDISTNDIPTCVCEKSLADKMEKTCLKCGGVLGTAVPELGLIGGSVIYSAAQAAAAKLGVAKAIELMKKIYNLGNVSFIDWTNLINVGNYSHRMSLVGIVNKVNNMCQIKDPEGNVVFCFAKQNMRGGAGKFAQTISEQAGNAAIKAGETANVKFAEMTSVGTIFSDPIVISATVVVTIAVILIIIYLILRYRRKKKMKKKLQYIKLLEE
Protein: Proteasome regulatory non-ATP-ase subunit (Q381Z4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Proteasome regulatory non-ATPase subunit 8
- Proteasome regulatory ATPase subunit 6
- Proteasome regulatory ATPase subunit 5
- Proteasome subunit beta
- Proteasome subunit alpha type
- Probable 26S proteasome regulatory subunit rpn-6.2
- 26S proteasome regulatory non-ATPase subunit
- Proteasome subunit alpha type
- Proteasome regulatory non-ATP-ase subunit 5
- 26S proteasome regulatory subunit 4 homolog
Sequence:
MLTTTDVGGVVRRINVDYKKLKAAYDQNNDSLCLNLVNGLKKQLILLPTFLNPAAASATWLEEVTLTREVLEYAVLVSARLEDLASFELYFNQLSVYYTDIDPTKLEESPLYSLILGLNLVRLLVDDRIAQFHTELEKVPNHIYAPNAYVRFAVLLERYLMEGSYSKLLNSRDQAPSKEYIPIVGMLEKTVRQGVAECIPHSYAKLSFERAQKILMVDSTDAVREIGKQYEWELGKDGASFVFTRREDIAKREVPFQEMLGHHLNFAADLQRIV
Protein: AvrPphE (HopX1) (Q83YM6)
Organism: Pseudomonas amygdali pv. tabaci (Pseudomonas syringae pv. tabaci)
Interaction partners:
Sequence:
MRIHSAGHSLPAPGPSVETTEKAVQSSSAQNPASCSSQTERPEAGSTQVRPNYPYSSVKTRLPPVSSTGQAISDTPSSLPGYLLLRRLDRRPLDEDSIKALVPADEAVREARRALPFGRGNIDVDAQRTHLQSGARAVAAKRLRKDAERAGHEPMPGNDEMNWHVLVAMSGQVFGAGNCGEHARIASFAYGALAQESGRSPREKIHLAEQPGKDHVWAETDNSSAGSSPIVMDPWSNGAAILAEDSRFAKDRSAVERTYSFTLAMAAEAGKVTRETAENVLTHTTSRLQKRLADQLPNVSPLEGGRYQQEKSVLDEAFARRVSDKLNSDDPRRALQMEIEAVGVAMSLGAEGVKTVARQAPKVVRQARSVASSKGMPPRR
Protein: Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Ubiquitin specific peptidase 48) (A0A0R4IB93)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86UV5}. Nucleus {ECO:0000250|UniProtKB:Q86UV5}.
Interaction partners:
Sequence:
MAPRLQLEKAAWRWAEAVRPEDITHEHIELAYRIAVSACKRGACRRNCKGNPNCLVGIGEQSWLGEIDENTFHNIDDPNSERRDKNTFVGLTNLGATCYVNTFLQVWFHNLELRRALYRFQNSRAEGHNTDSDYEPRTICEHLQYLFALLQNSNRRYIDPSGLVKALGLDTGQQQDAQEFSKLFLSLLEDTLSKQKDPNLQNVIQQQFCGQFSYVTVCNKCGRESPLPSRFYELELNIQGHKNLTECVTEFLKEEKLDGDNRYYCESCQSKQNATRRIKLQSLPRTLNFQLMRFVFDRQSGHKKKLNTFISFPEVLDMEPFLEGREEKCTYELSAVLIHRGVSAYSGHYIAHVRDAHTNDWYKFNDEEIEKMEGKKLQLGIEEDIAETAKSQTRKPKCSKGYHCSRNAYMLVYKQQTEEINQTESPVDVPAFLQKLVEQDNRKFEEWCSEMSDMRKQSVDKGKAKHEEVKELYELLPAEDGQSYEFVPLEWLKKWLDDSTAIKEIDNSQFLCTHGKLHPDKIGEAKRISLKAADLLFSRYGGGPRLDRSSLCRDCVTQRCRVIRLKNQLNEDYREVTNLAKSALKSEESGFWIGKASLRSWRQLALDQLEEDEEETKHNNSKINGEKSSPGTKADGVKGDSEDGDGEEMKNFNEDILCYHGGLSILENDRRLVSAEVWNKLRMYFPKAPEFTQDHDPCQQCMRLEREGKENEALNRMMANEQKSSLLNLFQEKNRPTLQKWPQDTDILYIVPLYFVEEWKKFIRRPAKGNPVSNVGNSILLCPHGGFMFTYDSMLQGDAQHIALLWPAEWEVISKMFLVDQVISICRIHDKTQDNGNVQYQTHPDLCRECREGFIFQQQRDMREYTQATVYVRKVIDKKRMIKESAPEFSVSGSDVEDEKEEPKLDGEKDPDFSQTEGGAKRQKLNDTVSLPTAVVTTTSKSGIRRSTRHRKLRGEKALIVSANQTLKDLKIQIMHAFSVAPFDQNLSIDGRCLKDDSATLGSLGVIPESIICLKADEPIADYAAMDDVYQVCMPEEGFKGTGLLGH
Protein: Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) (Q8CDA1)
Organism: Mus musculus (Mouse)
Function: Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (By similarity). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (By similarity). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress. May play a role as negative regulator of axon regeneration after central nervous system injuries.
Subcellular location: Membrane, clathrin-coated pit {ECO:0000269|PubMed:25869668}. Early endosome {ECO:0000269|PubMed:25869668}. Recycling endosome {ECO:0000250|UniProtKB:Q9Y2H2}. Note=Also found on macropinosomes. {ECO:0000269|PubMed:25869668}.
Interaction partners:
- Inositol polyphosphate 5-phosphatase OCRL
- Phosphatidylinositol 4-kinase type 2-alpha
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Synaptojanin-1
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Phosphatidylinositol polyphosphate 5-phosphatase type IV
- Phosphatidylinositol 4-kinase type 2-beta
- Synaptojanin-2
- Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol-3-phosphate phosphatase MTMR1
Sequence:
MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQELELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTNIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQALTEIGTPDVDFWIIPIIQGFVQIEELVVNYNESSDDDKSSPETPPQDSTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHHHTLSFIQTRGSVPVFWSQVGYRYNPRPRLDKSEKETVDCFCAHFEEQLKIYKKQVIVNLVDQAGREKIIGDAYLKQVLLFNNPKLTYVSFDFHEHCRGMKFENVQTLTDAIHDIIIDMKWCWVDQAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRTYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLSRFKDAYRQAVIDLMQGVPVTEDLYSIFTKEKEHEALHKESQRSHQELISQLLQSYMQLLLPGDEKFHGGWALVDCDPSLTDAAHRDVEVLLLLSNAAYYVAYYDDEVDKVNQYQRLGLEDLERIEIGPEPTLFGKPKFSCMRLHYRCKEAGGYFHTLRAVPRSPEEDGKDTLQCIAEMLQITKQAMGLDVPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKSFLMSKFSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENPGVMGNKVQGESDGDISSDNDSYHSDEFLTNSKSEEDKQLANSLESVGPIDYILPSCGIIVSAPRLGSRSQSASSIDVSTHAPSEAAAGPGSELGKGLESPLKKSPSADSIHTRTGFTKPMDVYCQRFVQDAQNKMNDLSEIRSVAQKSEEGSHKTNRVSNEETQSEPMGQTPPRPSQLNVSCSVAGPPFLSVEPVHSVLSQKTPSSGSSLLELEAGLCVTPSSESSSSRAVSPFAKIRSSMVQVANITQAGLTHGINLAVAKVQKSPAEPEAVNEIQQNELKNMFTQCQTRIIQI
Protein: ADAM metallopeptidase with thrombospondin type 1 motif 9 (F1SFS3)
Organism: Sus scrofa (Pig)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Interaction partners:
- Nostrin
Sequence:
MRPSSRAPVLLLLLLLGLLLQPKRLSSRQAAALLSRSQTGPSRETSATPKVKSWRRAPGSARSPRLLPRVAAAAKEGRREGGGGSGGGVGSTMQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIASPIRVNALGEPFPTNVHFKRRRRSINSASDPWPTFAASSSSATSSEAHYRLSAFGQQFLFNLTAHAGFIAPLFTVTLLGAPGVNQTKFYSEEEAELKHCFYKGHVNTKAEHTAVISLCSGMLGTFRSHDGDYFIEPLLSIDEQEDEEEQNKPHIIYRRSTPRREPLTGRHACDTPEHKSSHSQDKRKTRTRKWGARRSLADDVAVLKSNLATQALSAYGNKTDSTREKRTHRRTKRFLSYPRFVEVMVVADNRMVLYHGANLQHYILTLMSIEGPSISFNAQTTLKNFCQWQHSKNHPGGIQHDTAVLVTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPSQLPGLLYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVEGAHKGCRTQHTPWADGTECEPGKHCKFGFCVPKEMEVPVTDGSWGSWSHFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVVDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGKSEDDNYLALSSSKGEFLLNGDFVVTMSKREIRIGNAVIEYSGSDNVVERINSTDRIDQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSYGPWQACSKPCQGERKRKPVCTRESDQLTVSDQRCDRLPQPAPITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKIDDSFCSGHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTVQRCNEFSCPQWKSGHWSECLVTCGKGHKHRQVWCQFGEDRLNDRICDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPEPRRSTHSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEDGSVADESACATLPRPVAKEECSVTPCGQWKAMDWSPCSATCGQGRATRQVVCVNYSDHVIDQSECDPDHIPETDQDCSMSPCPQRTPDGGLAQHPFQNEDYRPRSISPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGSWGECSKLCGGGLRTRLVVCQRPSGERFPDLSCEILDKPPDREQCNTQACPQDPAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLEGDYCKHLPKPNGHRKCRGGRCPKWKAGAWSQCSVSCGQGVQRRNVGCHMGTHKVARETGCDQYTRPESERACQAPPCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDEDKGGEVHGVHCDMSTRPADRESCSLQPCEYVWITGEWSECSVTCGKGYRQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVQPCYLRECPVSASWRVGNWGSCSVSCGVGVMHRSVQCLTNEDQPSHLCPADLKPEERKTCQNIYNCELPQNCKEVKRLKGAGEDGEYFLIVMGKLLKVFCAGMHSDHPKEYMTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDDCQCRKDYTAAGFSSFQKIRIDLTTMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLAESARWISQGNYAVSDIKKSPDGTRVIGKCGGYCGKCAPSSGTGLEVRVL
Protein: Translin (Component 3 of promoter of RISC) (A0A8I6AEH3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
EIRKVVQSLEQTAREILTLLQGVHQGTGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACGEK
Protein: Immunoglobulin heavy constant alpha (A0A075B6A3)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
XSARNPTIYPLTLPRALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALASGGGYTMSSQLTLPAVECPEGESVKCSVQHDSNAVQELDVKCSGPPPPCPPCPPSCHPSLSLQRPALEDLLLGSDASLTCTLNGLRNPEGAVFTWEPSTGKDAVQKKAVQNSCGCYSVSSVLPGCAERWNSGASFKCTVTHPESDTLTGTIAKITVNTFPPQVHLLPPPSEELALNELVSLTCLVRAFNPKEVLVRWLHGNEELSPESYLVFEPLKEPGEGATTYLVTSVLRVSAELWKQGDQYSCMVGHEALPMNFTQKTIDRLSGKPTNVSVSVIMSEGDGICY
Protein: 60S ribosomal protein L27 (Q6FMN5)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Interaction partners:
- Large ribosomal subunit protein uL5
- L37
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein uS9
- Candida glabrata strain CBS138 chromosome K complete sequence
- Small ribosomal subunit protein uS10
- 40S ribosomal protein S12
- L1c
- Large ribosomal subunit protein uL3
- L2
Sequence:
MAKFLKAGKVAVVVRGRYAGKKVVIVKPHDEGSKAHPFAHALVAGIERYPLKVTKKHGAKKVAKRTKIKPFIKAINYNHLLPTRYTLDVESFKSVVSTETFEEPTQREEAKKVIKKAFEERHQAGKNQWFFSKLRF
Protein: Ig-like domain-containing protein (G5ECH3)
Organism: Caenorhabditis elegans
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Tubulin beta chain
- Acetylcholine receptor subunit alpha-type unc-38
- AcetylCholine Receptor
Sequence:
MIGRLRRGFILFPQLFLLFVSISSIFLFVLVECKPPKSLNRMRSKGTYNAAAFNSPSMINNGLLLAGFENNDTSRETRESYEEYKDDIDHLLEGDLTFYDEGADTAAGDVVITSETPVEKHKEVHFKNEPEEEEIGKEDDGGGEAEEGEYEEENGSDAEEEEESPEKVEPATSTITTEAQTTTTPEEVTQDVSDNIEDDEDARPKSEEHSPKHAASSSDLFEDDDQSTTLESIARLSAPAHVPIEQPQTSDTEILEHLLTRGYDHRVRPPGEDGTIHGGPVVVSVNMLLRSISKIDNVNMEYSVQLTFRESWVDKRLSFGVKGDAQPDFLILTAGQEIWMPDSFFQNEKQAYKHMIDKPNVLIRVHKDGTILYSVRISLVLSCPMHLQYYPMDVQQCFIDLASYAYTTKDIEYVWKEETPVQLKAGLSSSLPSFQLTNTSTTYCTSKTNTGSYSCLRTIIQLRRQFSYYLLQLYIPSCMLVIVSWVSFWIDRTAVPARVTLGVTTLLTMTTQSSGINAKLPPVAYIKAIDVWIGACMTFIFCALLEFAWVTYIANKQDANKRARTEREKAELPFLQNSHNDVWVPREVAEQEREVMTVRMNRRQTNSVWKWIKTKTEWNDKSKRADLISRVMFPVLFLTFNISYWTHYGQYGVAIST
Protein: histone acetyltransferase (EC 2.3.1.48) (A0A8I6GLZ3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MVKLANPLYTEWILEAVQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDHPGRFSSVKPGTFPKPTKGPKGPPCNDLRNVDWNKLLKRAIEGLEEPSGSSLKSIEKYLRSQSDLTGTTDHPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNTGSSDGRGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELVSCADCGSSGHPSCLKFCPELTANVKALRWQCIECKTCSACRVQGKNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVTSDEGSVNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKTTTSSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHMLATGTTQKLKPPPSALPPPAPISGQSPSSQKSSTSTSSAPTQSSSSRSSEPSFSSLINSSQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTEFSSTAKAKACFFGKRDFRSRFLSHSSCSWGMTRGHIFKAIAHFKRTTFLKKHRMLGRLKYKVTPQMGTPSPGKGSLADGRINPDQDNDTEIKISIKQESMDVNVMGNKDLVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYRHHERHISIKAISRATGMCPHDIATTLQYLHMIDRRDGRFVIIRREKLILGHMEKLKNCSRPNEVDPESLRWTPILISNAVVSEEEREAEKEAERLMEQASCWEKEEQENLSSRVTSRQSSAKVQSKNKYLHSPERRPVAGERGQLLGLSKESSEEEEEEEDDEDEEEEEEEEESIPTSPPRLTKPQSVSIKRKRPFVVKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPRLEPTCEIQVEEAGRKPVLRKAFQHQPGKKRQTEEGDGKDNHFFKNAALCRNDVDDDAEHLEEGSRDSAEPLKCRQVWPKAAKRGLSKWRQSKERRPGLKLNLCTPPETPMEPEGLTKVVKEQKGISEDKGSPVGEDREVTETEEALLPQDGNGREETGTPVSPHKSPGGKADEEDLIKGEEEEEEEGTTEKDPDGAKSKEKAEAEISMEKEDAVHLDDHEEDEDEEEEPSHNEDHDADDEDDGHMEATNVDRGDLPKEAFKDALEGQEAFLGLSIQPSHSDPEGLVNCGGDLAVSCGSEPKELAGDAGTAPESDSELPEEQTQEQDQEKSNGADTELKDGGTATVEIDSETVQAVQSLTQENREQDDTFQDCAETQEACRSLQNYTHTDQSPQIATTLDECQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQTAITVPPLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQNSCSYGSLTSSSLTQSSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLADIPETSNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAATSYANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIASKGPVSMRTKSASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGTQPYAQQPMQTPPHSNMMYTAPGHHGYMNTGMSKQSLNGSYMRR
Protein: Protein irg-2 (Infection response protein 2) (O16224)
Organism: Caenorhabditis elegans
Interaction partners:
- Protein irg-1
- Uncharacterized protein
- Transcription factor zip-2
- CUB-like domain-containing protein
Sequence:
MFDEFYFRKSLRPRESQNHVRNAACEYILKFMKTEGTIVKTYHLGSSLEPWGRKFHERIDRTVFDQDLTPFVKYTLNKKKRWEAEGNPDILYGLQRSYQNMGVMVAERVSLRSTPHYCIVSINNYYRNFFDQFPIRHLHQLQDHNYQCQSTNSIRGQPFKSLQPENRTPTQVTGHQQESSANVSVAYHIITPPKNYEVLRNKDFRVGHSDRNGIRTIARRRRFQFMKEAVFDLKNEILEDFGDSDDDDENEILLCEESCGPRKFYNLHDHLVKSNHNE
Protein: Holliday junction recognition protein (Fetal liver expressing gene 1 protein homolog) (mFleg1) (Q6PG16)
Organism: Mus musculus (Mouse)
Function: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
Subcellular location: Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage (By similarity). {ECO:0000250}.
Interaction partners:
- Histone H3-like centromeric protein A
- Nucleophosmin
- Histone-binding protein RBBP4
- Histone H4
- Mis18-binding protein 1
- Centromere protein F
- Disks large-associated protein 5
- Kinesin-like protein KIF2C
- Proliferation marker protein Ki-67
- Histone-binding protein RBBP7
Sequence:
MESMGRQDRRLHQQLKESSSRFQTLMKRLIAKYNQPFEDDPLVEMRTLTYETPQGLRVWGGKLMKKEDKEYTQVIDRLNGQAPEGDSESSGADTSLEENWPSCSSAMREASGDPRQRQPAVPGNTLETDLRRKYLTQVDILPQDEEYFKNAEKRGGKDTVMTWVPSVTSSVTPASGCQDAISAKSSGGPEVSALSSRGQGPSYPCPADMAIVARSDGLSLLGTSSNSVSSQSFEVDDLCNVTISDLYEGMMHSMSRLLRSKPSCIISTKTYINQSWKLRRRPSRKQGLHKNRTHCPRSKPSQRSARKGPASCSEPGKEAGILRDYGNLLHVAPHKTGLELKSVSLEGSKRQVHKSSPAWKELQMMPQKDLDLNRERENRVMTLQWLISPVKVVPRPRMLPSQVEKWYREIKIKFDKLHQEYCLSSGKQPRLTDPTESWAVDVYRSGSKSPGSRQDVETCRPSSPFGREKTERPGEALEDLRGNGKSVKTKSCLLRSCPSPEGSPSRSPSHSQLSSGLQEHNSEPTGKAVWPSTAISAPSIGSPGCGKDNYYELKKEFNRLYQKYCLSPQRAKVTSCGRVSPMKAAAALPCQSEHLKRLNPDSPQQSSQKRSISPGCHRRVLQDSTAQTASTLVRDSWLPTKRCKLSYPVACAHQAKFHDTSGASGWP
Protein: WH1 domain-containing protein (H2L0C7)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MTYNESTKGWVLLGGNDDSMTNVRLIQDIRRPEFRIVSNRADSTNILNCNIYRGIKYHKATPMFHQWRTEQRRVYGLNFENEQDATMFLSIVLQAIETLKVHDMNGISDYQQMHQVDNVYQDPHQHLMHIHSAPNFHDENQNAANFRKTSQHASSLLSSTAAALTQQQRRASQSSSTSAGSSIPHAPPPPVPLTSNIPQAPPAPPPPIGGIAPVNAHGAPPPPPLPPVGAGAPPPPPPPPPPAQLMASSGTPSLAEQLKMRSQQGLKATSNGVKAAAAEPEKPAAKGGKNIGKCVKFLEKIEFFSLVFQR
Protein: Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (SSX2-interacting protein) (Q62739)
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (By similarity). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7532276}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin (By similarity). {ECO:0000250}.
Interaction partners:
- Ras-related protein Rab-8A
- Ras-related protein Rab-11A
- BBSome complex member BBS1
- Rab11fip3 protein
- Exocyst complex component 6
- Ras-related protein Rab-8B
- BBSome complex member BBS4
- Centrosomal protein of 164 kDa
- Outer dense fiber protein 2
- Ras-related protein Rab-10
Sequence:
MANDPLEGFHEVNLASPTSPDLLGVCDPGTQEQTTSPSVIYRPHPSTLCSATIQANALNLSDLPTQPVYSSPRHLNCAEISNISIHVPEPASSVASEVAAGLTRFTSRKDSCNAEREFLQGATVTEASAGNDDIFGLSTDSLSRLRSPSVLEVREKGYERLKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANVKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLAAGKTPFKRGHTRNKSTSSAMSGSHQDFSAIQPIVKDCREADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLTFAKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKPCKHRIKLGDSSSYYYISPVCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKEEL
Protein: Probable glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase) (O13810)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
- Probable gamma-glutamyl phosphate reductase
- Probable delta-1-pyrroline-5-carboxylate dehydrogenase
- Ornithine aminotransferase car2
- Pyrroline-5-carboxylate reductase
- Anthranilate phosphoribosyltransferase
- Protein arg11
- CTP synthase
- GMP synthase
- Glutamate synthase
- Putative glutamine amidotransferase-like protein C13C5.04
Sequence:
MSPKSKSTNKTYTIVIKLGTSSICDEKTHEPLISNLSLIVETVVKLRKLGHNVVLVSSGGIAMGLRRLDLPKRPSKLSAVQAIAAVGQGRLISLWDTLFTQLRQPIAQVLITRNDIAERSQYVNAANTISELLHFGVVPIVNENDTLSVQEIRFGDNDTLSAITAGMINADYLFLLTDVDCLYTDNPRTNPDAKPILKIHDTSMVNANVSTPGSGVGTGGMKTKLIAADLGTSSGVNVIICRGSKPSSIFDIIRQESSDNKNESVELPLHTHFVAKKQGRIRDRHFWLLHGLKSHGSLEIDRGAFEAITRTNRAGLLPVGVTKVHGHFSAHQAVTVIYNGEEIGRALVNYSSTEIDLIKGKRSKEIASILGYNETEYVAYRDYLVVHGLNSHHDSQVSSDEH