wanglab/gogpt-training-data huggingface dataset:
Protein: DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) (Q8TEH3)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity).
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}; Peripheral membrane protein {ECO:0000269|PubMed:20937701}. Presynaptic cell membrane {ECO:0000269|PubMed:20937701}. Note=Associates to membranes via lipid-binding activity. {ECO:0000250|UniProtKB:Q8K382}.
Interaction partners:
- Ras-related protein Rab-35
- MAP kinase-activating death domain protein
- 14-3-3 protein epsilon
- DENN domain-containing protein 1B
- Clathrin heavy chain 1
- Aminopeptidase O
- Serine/threonine-protein kinase Nek6
- Lutropin-choriogonadotropic hormone receptor
- Ras-related protein Rab-5B
- TOX high mobility group box family member 3
Sequence:
MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLVEAKDPKLREDRRPITVHFGQVRPPRPHVVKRPKSNIAVEGRRTSVPSPEQPQPYRTLRESDSAEGDEAESPEQQVRKSTGPVPAPPDRAASIDLLEDVFSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLDLGGSERSRGVTVALKLTHPYNKLWSLGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSILNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFASGLLLSSAGFCAPHRSQPNLSALSMPNLFGQMPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPRPPQGLEPTLQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDSVEQLRKQWETFE
Protein: Homeodomain-like superfamily protein (Q9LRX5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Duplicated homeodomain-like superfamily protein
- At1g49010
- Protein REVEILLE 5
- Transcription factor HHO5
Sequence:
MATPSPTSSPPSDSNPNSAATPPHQKQPPSPPQPTNPSSPPPHTTVVALAASTSAVARKTQPVLWTQDETLLLIESYKEKWFAIGRGPLKSTHWEEIAVAASSRSGVERTSTQCRHKIEKMRKRFRSERQSMGPISIWPFYNQMEELDSSNPAPISARPLTRLPPNSNNRYVDDEEEDEEEDNNNYEEEEEEDERQSKSRSINYILRRPGTVNRFAGVGGGLLSWGQKERSSKRKRNDGDGGERRRKGMRAVAAEIRAFAERVMVMEKKKIEFAKETVRLRKEMEIRRINLIQSSQTQLLQFINNAFDSF
Protein: Transcription factor Atoh7 (Atonal bHLH transcription factor 7) (Helix-loop-helix protein mATH-5) (mATH5) (Protein atonal homolog 7) (Q9Z2E5)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3'. Dimerization with TCF3 isoform E47 may be required in certain situations (By similarity). Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes. Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract. Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription. Required for retinal circadian rhythm photoentrainment. Plays a role in brainstem auditory signaling and binaural processing.
Subcellular location: Nucleus {ECO:0000269|PubMed:33712461}. Perikaryon {ECO:0000269|PubMed:17977745}. Cell projection, axon {ECO:0000269|PubMed:17977745}.
Interaction partners:
- POU domain, class 4, transcription factor 2
- Visual system homeobox 2
- Visual system homeobox 1
- POU domain, class 4, transcription factor 1
- Cone-rod homeobox protein
- Forkhead box protein N4
- Paired box protein Pax-6
- Insulin gene enhancer protein ISL-1
Sequence:
MKSACKPHGPPAGARGAPPCAGAAERAVSCAGPGRLESAARRRLAANARERRRMQGLNTAFDRLRRVVPQWGQDKKLSKYETLQMALSYIIALTRILAEAERDWVGLRCEQRGRDHPYLPFPGARLQVDPEPYGQRLFGFQPEPFPMAS
Protein: WASP actin nucleation promoting factor b (Wiskott-Aldrich syndrome (Eczema-thrombocytopenia)) (Q7T318)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSKGKSKGQENVSSSLLSSLENERLQELLGRRCVAMATAVVQLYMALPHSPTEWSLQHTGVMCFVKDNPRRSYYIRLFDIMEAKVVWEQELYNQMTYSCPLRFFHTFAADDCQVGLNFASETEADLFRNITEEKINQRTNRQEKRQHAPSEDKRPLPQIPPPNGPVSQPSVMATVDIQNPDIVASRYRSTSVPTPAPACITTGKKDKKGKKKGPKLTKADIGAPSGFKHVTHIGWDPNSGFDTNNLDPDLKKLFNIAGISDAQLADKETSKLIYDFIEQSGGLDAVKEGMRKQVPGGPRSAPAPPPPRGGLSSVPGPTGRPPPPSRSPGPPHRGPPPPAPHCNRSGPPPPPPPSQSHKPPPPPMGACAPPPPPPPPPPPSSSGNFSSSPVSSAPPPPPPSGGGGGGGGRGTLLEEIRRGRVLKNVSESPDPNPPAQEESSEGIVGALMMVMQKRSKVIHSSEDEEDDGGEEEEDDEWDD
Protein: Protein FAM218A (Q96MZ4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MEGCAVRRGSCPLLPGPSAWRASPAGWAGRAKLRSWCRASGLPNRPYTLTGGRHGSVSLLRHPGTTTFVQQRSLHQSWEKRIVFSACPVSRSWCPERNFSGSIPAVTPPKLPGHSKSEGPPGKVRKRTTIRSQPLFVTRTRGFGSAVGWLPLGSPVL
Protein: Histone-lysine N-methyltransferase set-6 (EC 2.1.1.-) (EC 2.1.1.366) (O17679)
Organism: Caenorhabditis elegans
Function: Histone methyltransferase that specifically di- and trimethylates 'Lys-9' of histone H3 (H3K9me2 and H3K9me3, respectively); involved in positively modulating the rate of age-related behavioral deterioration. May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with probable chromatin reader protein, baz-2. Involved in modulation of the mitochondrial unfolded protein response (UPR). Regulates level of expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase). Negatively modulates levels of endogenous 5-HT and dopamine with aging. Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function.
Subcellular location: Nucleus {ECO:0000269|PubMed:32103178}. Chromosome {ECO:0000269|PubMed:32103178}.
Interaction partners:
- JmjC domain-containing histone demethylation protein 1
Sequence:
MERSRTGGSSTYSMSTANVPIITISDDDDELTIWEEPRKSPISSNSYSDERNHSLSSTSNSSVERSIIITISDDESEATERNQQEVVDRAISNNLTEKRRRSVESFHRLHSKERKLEVKSRKKSRTSSSSMEASTSCTFPARQTKTKRHKRKTYSTISSFAPHHSTICAELRNVNPARIADFRHPSIFEYSDMSLNERREHWKKEMKVIKKHNDIRLMHEEAVRFDDIIELDPTLNGYYRRFMGAEQSTRALFMAVRCLATFGRNFYEEPERDHGEEEIPEELDRYFEKLIYVAPRTRIRITDDIHLSNDTHRIPVYTDAKGETLKTVKIPNPLLYDHIINNMVDKVKEPLLYEAIKIAGSSENVIRCKCCSQDPVVNCFDNKDCPCFIANQFLQSRNKTTDTNEKLKFHTFQPLMYNDGNPTYYNTVGFACSPKCACKGACTNNATYLIQKKLYSIEIYRADPQIGFGIRSTLFIPAGTPIIEYCGELVDGERLHSSLENYSYQLTDCEGDKHLYNLLREKYKNNPEYYDVLDELSKHHFHLDAKMQGSVGRFANHSCTPNMEPLRLFKEGFTPANMRMIFFTLKDIFPGEPLTLDYGSEYKVFRRQRCLCRTFACRSGPHYEKFSNLDGKLIASCFVRLHHASRIRYSVDLQLIERFYSVGKVEEVRVDPCVSFSKYNLKWRRQLSTATCERLENVIEIELSDEDS
Protein: WPP domain-interacting protein 3 (Q94AV5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips. As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes.
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:17600715, ECO:0000269|PubMed:22270916}. Nucleus membrane {ECO:0000269|PubMed:17600715}; Single-pass membrane protein {ECO:0000269|PubMed:17600715}; Cytoplasmic side {ECO:0000269|PubMed:17600715}.
Interaction partners:
- Farnesylcysteine lyase
- GATA transcription factor 28
- Probable inactive beta-glucosidase 25
- Protein TIC 21, chloroplastic
- Spermidine synthase 1
Sequence:
MNESVPDSVEDNGNSVPANGLLVLPDNDHEEGGVGSPQRSNSVESPGGSVHSTRKGFGLKKWRRIKRDGPVRDEAAPVDDGSKLLKRGLAGLVNPPSKHVEFSSVEARQSSEGSVGSVNMVHHPGVANGFSPDIGCMFAVGQAFEKSEEHSGNTIGGKNVVGGKVVSGSQEKLWSDTIKRASEERGDIEKEKPCSSLDSDLRSSDFVFSTGSVSVGNHGEKDERLTMNYIGGFSNEGQVKEEVQTYSRSENGNKEDDGESKKNNNHWADKDALADSIRSFAVLQEVLWKEVQSFQELGKESVLLHSNTDELSSDQPSHQNCKEDNSTSSGSKALILKEKVKLLEHKLEEARAALEAKEARIQELENSKIESELECIFQRKIETEIEHLMLTRSLSSLQVLQETKKLHSLKEDPVSNRGNILGKTCKLGFYILTQLILLVSILRFLVLQFSPASRLVIPT
Protein: CC domain-containing protein (Q19618)
Organism: Caenorhabditis elegans
Interaction partners:
- Nuclear receptor domain-containing protein
- tRNA
- Serpentine Receptor, class Z
- CUB_2 domain-containing protein
- Kinesin motor domain-containing protein
Sequence:
MTRRFALIALLFALTSAQTTTQSKQISLDPNAGPLKLRIVFQSEQPPQVQQTPCSTGNCQPTPTLSPCASGNCGSVQPVQASPCSTGNCGVTQQASACSTGNCNGPVAGSANVVPVFDASIYTTTTPMPIPIRTISSNTAPIKVIRVPSYSNSNNGCFSPPCGAPRFIFAQPPCFGNSCGPRFMFPRRRHFFGPRPIIIGNRNNGNINAGGNVAVPDTIYKNGMAIRAPIRVPSSYQDGNPVFNSGK
Protein: AT5g10910/T30N20_180 (MraW methylase family protein) (Q9LEU9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein mS29
- Translation elongation factor EF1B/ribosomal protein S6 family protein
- At1g64880
- At1g45110 Methylase)
- Probable inactive ATP-dependent zinc metalloprotease FTSHI 3, chloroplastic
- Small ribosomal subunit protein uS9c
- Small ribosomal subunit protein uS9m
- tRNA pseudouridine synthase
- Probable inactive ATP-dependent zinc metalloprotease FTSHI 2, chloroplastic
- Small ribosomal subunit protein uS2c
Sequence:
MAGVIRAKQLFLCSSILSSNNNKVLSRLPRRSINVIAGNLNSSETKKKEKEKRKRRKEIEVEKATAEAVVNKEKRRTRSSRGYELADGDEVPSSHVPVMLGEVLDIFSSVRLRSFVDCTLGAAGHSSSIIQSHSELKNFVGMDVDPVARKLGHFHIDSLMHPTLKASIVLKNFKYIKSVIADTQPELLDVGVDGILMDLGMSSMQVNNPERGFSVLQEGPLDMRMDPQATLTAEDIVNSWPESELGRVLRDYGEESNWYLLQNRIVKARLNGGLHSTGELVDLIRGTSPASRGGRQGWIKTATRVFQGLRIAVNDELKTLQNSLYSSFDVLAPGGRLAVISFHSLEDRVVKQTFLDILGFQREEINGEGSSVKPERQIEERVEKELKEKEEWIKQTVIASKGVILTKRPITPSEEEERLNRRARSAKLRVIQKL
Protein: Betaine aldehyde dehydrogenase 1 (OsBADH1) (EC 1.2.1.8) (O24174)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Dehydrogenase that can use N-acetyl-gamma-aminobutyraldehyde (NAGABald), gamma-guanidinobutyraldehyde (GGBald), betaine aldehyde (Bet-ald), gamma-aminobutyraldehyde (GAB-ald), acetaldehyde, 4-aminobutylaldehyde (AB-ald), 3-aminopropionaldehyde (AP-ald), 4-N-trimethylaminobutyraldehyde (TMAB-ald) and 3-N-trimethylaminopropionaldehyde (TMAP-ald) as substrates. Catalyzes the oxidation of GAB-ald more efficiently than Bet-ald. May convert acetaldehyde into acetate, thus facilitating the production of acetyl-CoA in peroxisomes under anaerobic conditions.
Subcellular location: Peroxisome {ECO:0000269|PubMed:19850038}.
Interaction partners:
- aldehyde dehydrogenase
- Delta-1-pyrroline-5-carboxylate synthase 1
- Os06g0258900 protein
- Betaine aldehyde dehydrogenase 2
- Delta-1-pyrroline-5-carboxylate synthase 2
- Os06g0698785 protein
- Os04g0573100 protein
- Os12g0604800 protein
- Proline dehydrogenase
- HOTHEAD protein, putative, expressed
Sequence:
MAAPSAIPRRGLFIGGGWREPSLGRRLPVVNPATEATIGDIPAATAEDVELAVSAARDAFGRDGGRHWSRAPGAVRAKYLKAIAAKIKDKKSYLALLETLDSGKPLDEAAGDMEDVAACFEYYADLAEALDGKQRAPISLPMENFESYVLKEPIGVVGLITPWNYPLLMATWKVAPALAAGCTAVLKPSELASLTCLELGGICAEIGLPPGVLNIITGLGTEAGAPLASHPHVDKIAFTGSTETGKRIMITASQMVKPVSLELGGKSPLIVFDDVDIDKAVEWAMFGCFANAGQVCSATSRLLLHEKIAKRFLDRLVAWAKSIKISDPLEEGCRLGSVVSEGQYQKIMKFISTARCEGATILYGGARPQHLKRGFFIEPTIITNVSTSMQIWREEVFGPVICVKEFRTEREAVELANDTHYGLAGAVISNDLERCERISKAIQSGIVWINCSQPCFVQAPWGGNKRSGFGRELGQWGLDNYLSVKQVTKYCSDEPYGWYRPPSKL
Protein: Cholinergic receptor, nicotinic, beta 1 (muscle)-like (Nicotinic acetylcholine receptor subunit beta 1a) (E7F2Q4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034104}.
Interaction partners:
- Acetylcholine receptor subunit alpha
- Cholinergic receptor, nicotinic, alpha 2a
- Cholinergic receptor, nicotinic, alpha 4b
- Cholinergic receptor, nicotinic, alpha 7
- Cholinergic receptor, nicotinic, beta 4
- Cholinergic receptor, nicotinic, beta 1
- Acetylcholine receptor subunit epsilon precursor
- Acetylcholine receptor subunit gamma precursor
Sequence:
MVWLNINYDINGSRKASEAERRLLEDLFQDYNLKVRPARTWNERVMVRVGMTLVQLISLNQKNGEMTTNVFMNMEWTDYRLSWNPEDYDKIDVVRIPPVKVWRPDIYLINNNDGQFDVALYVNVLVRSDGTVSWLPPAIYRSSCSIEVAYFPFDWQNCSMVFRSYTYDSSEVDLQYGLDEDGNELHEIVIDENAFTENGEWQICHKPSRKNVQDDLYEDITFYLIIERKPLFYVINIIVPCILTSVLAIFVFYLPPGAGEKMTLSISVLIALTVFMLLLADKVPETSLAIPIIVNYVMFTMILVTFSVILSVVVLNLHHRTPSTHHMPGWVRKVFINLLPRYLGVLRPTPEEPVEEEPKENVPMGCLGNSLRPGGEYFIRKINPELVMPWRGSHNESTVKLQRFSNSDNYCLILPPNLKSAIAAITYMSEQLKKQDVDDTMTDDWQYIAVVLDRLFLWLFVVITTLGTLTMFLDASFNYTPDQPFP
Protein: RE61780p (Q6NR50)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MESPLLPKANNNLGMDKMSSSLNSSTMEDTTPSDSGVQLLDSENSDVMVESICSYEENVRPMPLPLVDPNSNVTAAPDESMTISECSTFDTTEKIVYRRKVHKASSASKTPKKRVSFHEDILKNTRTDNIHIEHGFITYKNGRKLAFANSAGVAGAPGRYSWCPDRERPEGPNELSAAGREDDGEEATGGGGARRKRHLVYRNACSDVLDYDNIFDTDEAPGLHYDTSGVFEYGPATQKQEEQPQLYKCVCSSSNSSLDSDEQDKNSNANCKQYEQAKSSSCDCIGMSNANNNLIGDNCYYSEPNIGDADSPKVKSVWNKEKKPKSSCLKKTKLHTNVILEQDLNGRVKKFNVHDIKHQLLDNSSKMIFGSLKSIFTMPLPERGVPEGSEDLQAVVECVPELEQTPEHKSRPAAESPPLRAKPFLSKSLDGSKQAQPVKKFVHNVDEQLRHKNEDDGASSTEASPMESKQSLMLHRQEEFDKETVPMGSAQGEFRSKFIINCESTVFEHTGVSYETGDLQSELSSGIQHTSVASLLEQNTPIAEPAASQIKKSFLDAPIAKTFSNFFRSFKDSTPVAKDEQAVTDNYFASKIAKPQQQAPAAGKLQRNFSSSTISEPSSNTNTSSNHQIAMNPQLGNAERQSRHLPSPLKKRGQPLQPPRYYDQQHPHQSRSLHSPSAYLAAGRGGPGGSGRDSKSTILSEEFDDILTITTTDTTNARSMDSDLVIVDYTDVDYAHLLKPPAPAAKTSLINRFLRNVTQKKIMETSIRKNNFFADKLRTEQRHAGSDLYVKGARPKNYELIDDLNAEIAMEIEMCGTNSPRRELAISLDNDFQGNLSNFELGIGEISIDVFKGKSLFNLKQSNEQLMKAFKLYTGYNVDGIMTPVLVLLTDKTLYVVNMEGNSLCVKFVLAYKDLDVILMGPFGNTVLLSNSNRDMQQVLLAGGPYPAGSLVANLELCARRSGSTLPAVGQLTLEHLAPLQAFVRANSCVGVAEHWMLYAVVNVPAGGSMRVESPSELLGPSMKGFLMHRRLRQTISTSAANRIFWQPGYFLLKAGVLYMFNDSTQRLPSWAMALAECQGARRTVKSERPHCFEITLKGEVLQMAAPDEYVASEWLQALLQSASGLVVQEEKHKTLGCTLIVTDNHLITLREDFSAPLRKISQQADNNAAVQGNKETMLEEDAQCF
Protein: Ecm7p (Q59US7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- Calcium-channel protein CCH1
- Mid1p
- Calmodulin
Sequence:
MLLWRNLVYNITLPFKNLNKEDRIIQLCRLFTCLIAIVCCLACIVAPRVTNTTYAARINCSHLDVANGLYESLRNSVTQVFTPAIFNDQMSGTGNSLTTSEIKLITEYAETQVAGSPQYCISSLWTWCYGNYETYTVVGKDGEIYTKKKNEVLTCTDKSSYVFDYINQLESIGLEIILAYAYQSSTFTTTSYEKQVSSRNAKFQLAFNGIIFTCCAQFVILICIFVIYSNRGSSRDLSKIPSLVLHVVTLISLASSLSIIIGSAMITNLFIITRNEIKSKLGDFGVTFHMGSKWFSFLSLSAVFATLSSMSWIFPMWCANPSISLTDQDDVVSFYEVPTRRTEFERHTDFRAKRSTAKFKSFEPNSGHGRNKIGNIFHNPRHSAHQDDHHEEEMRKLGESLSKKSSVRRTKSLGARKAELEEQGILLDNFTFKDEYPTIQEETYDGYSSRSVSRSASDKVSRKVSDKRQRHLIREVIKSPFDEEDKTDGISPRNSYLEDDELQLLDNQMFNLKK
Protein: ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) (P90521)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
Interaction partners:
- Glucose-6-phosphate isomerase
- Transketolase
- Fructose-bisphosphate aldolase
- Fructose-1,6-bisphosphatase
- Triosephosphate isomerase
- Probable transaldolase
- Pyruvate kinase
- Probable mannose-6-phosphate isomerase
- Phosphoglycerate kinase
- isocitrate lyase
Sequence:
MTTTSKIINDGEGEDVKGNKNINKKSLIDENRLDEKKDLLSDKVESKTHCSVKRMAVLTSGGDSSGMNPAIRAFARQVMLKGAKVFAVREGYNGLVNDSIVPLNWGSVAGIISRGGTIIGTARSAEFRTREGRKRAVFNLVKNRIDNLLVIGGDGSLTGANLLRTEWCSLLEELVKDGKLTLDVMEHFPILSIAGIVGSIDNDMCGTDLTVGADTATKRILEAIDSILSTAVSHQRSFVIEVMGRNCGWLALASGVATGADYILIPESPPDDGWEQTMADNLERGRLSGRRCSLVIVSEGAIDRQGKPITSAYVRQFLEDKGHDARITILGHVQRGGTPTFLDRYIATRMGIEAANYFYDSTIEQLKQPVLIGMSGMDTIRSPLMECVQKTQSIASLIKERRFNEVVDVRGGMFKEFYEIFIACSNLHRRKVESKGMGVLILHSGGPSPGMNPCVRAFTRLGIDHGYTMYGCFNGFGGLALGEIEQLHWMTVNGWSVMGGAELGTNRSIPNDSNIEAIIATLERFKINAILMFGGFNGYLGIAKLYEYREKYQQLKRISIIGAPGTIANNVPGTNISIGSDTSLNNTLDALDKIKQSAVASRRLFVVEVMGAHCGYLAAMSSLTSGAERSYIMERGITLNTLTKDLEMFVERFKREHRIGLIIKSELASNTYSTHFIYSLFKEEGKHLFDVRESILGHLQQGGTPSAIDRIFSTRLMNHYYQFLENDLKEHGHLQMNGCIGFIDGGIHYTPMQEMIEEMSDKFRRPRSQWWMDLVETSQNISVFPLDDPSSTNFEGCNSNLSEQDRPIKKSDISSPTSYSQKTFDPNVNPQFTL
Protein: Bent (Q8T6S9)
Organism: Drosophila simulans (Fruit fly)
Interaction partners:
Sequence:
NVDYNTKLKVNSATRSDSGIYTVFAENANGEDSADVKVTVIDKPAPPNGPLKVDEINSESCTLHWNPPDDDGGQPIDNYVVEKLDEATGRWIPAGQTDGPVTALKVKGLTPGHKYKFRVRAKNRQGTSEPLTTTQAIIAKNPFDEPTKPGTPTIKDFDKEFVDLEWTRPEADGGSPITGYVVEKRDKFSPDWEKCAEISDDITNAHVPDLIEGLKYEFRVRAVNKAGPGLPSDATETHVARSKNTPPKIDRNFMSDIKIKAGNVFEFDVPVTGEPLPSKDWTHEGNMIINTDRVKISNFDDRTKIRILDAKRSDTGVYTLTARNINGTDRHTVKVTILDAPSVPEGPISN
Protein: Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) (P47736)
Organism: Homo sapiens (Human)
Function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein.
Interaction partners:
- Ras-related protein Rap-1A
- Ras-related protein Rap-1b
- Ras GTPase-activating protein 1
- Ras-related protein Rap-2a
Sequence:
MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASSFASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHPDAGKLGDPACPEIKIQLEASEQHMPQLGC
Protein: Eukaryotic translation initiation factor 1A, putative (Q57YI9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Protein translation factor SUI1 homolog, putative
- Eukaryotic translation initiation factor 3 subunit 8, putative
- 40S ribosomal protein S16, putative
- 40S ribosomal protein S8
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S18, putative
- Translation initiation factor, putative
- Ribosomal protein S19, putative
- 40S ribosomal protein S15a, putative
- 40S ribosomal protein S13, putative
Sequence:
MPKNMGKGGKSFKAGNAKGIMQNQKREIVLANPDENEEYAQVKKPLGNLRLELQLADGSKVIGVIRGAMVRKVWIGQGDVVLVSKREFNENDVVDVIHRYTPQEVRKLVKKEIIPRDFRSADERDANNAHSDYVFVAENDEDDDDDDDDDDAKVIDRHKVVLDDPLANFDDL
Protein: F-box protein SKIP31 (SKP1-interacting partner 31) (Q9FHK0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Interaction partners:
- F-box protein SKIP22
- V-type proton ATPase subunit c''1
- F-box/kelch-repeat protein At5g49000
- O-fucosyltransferase 7
- F-box protein SKIP24
- Putative RING zinc finger protein
- Probable ubiquitin-conjugating enzyme E2 23
- Ubiquitin-conjugating enzyme E2 29
- Transmembrane E3 ubiquitin-protein ligase FLY1
- Ubiquitin-conjugating enzyme E2 11
Sequence:
MSVSDEEDECFARFLESEVSSVEDKEETKEPEAKRQRIEKGETKALEKDEDQKENGNKDKTDAKRIESGVFTNVPTELFRHILKFLSSEDLVSCSLVCKFLNFAAADESLWRRLYCIRWGLTLPSRKLRESAWKKLYIDRDEQDMIELVRTCPSDFKEYYVHMQAAKRSQAPLPSQMVDDRIILDNTVLEQVSLWKKSKGLTDKAVTGHICLGTKCSYHQIDDVFICKETGNVHVCDDNCKEVILSPEGDLMVCTISGVCSDTLLVQTEPDADGCYEEEAELEAEVFTDKSRLARAFELGYNCDDEQELERTLRFC
Protein: Anion exchange protein (A0A2R8QD45)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Membrane {ECO:0000256|RuleBase:RU362035}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362035}.
Interaction partners:
Sequence:
MSAGKRVEDEAVLDRGASLLKPLCDQEEVEGHHTIYIGVHVPKSYRRRRRHRRRTSHKDRKEKVSENTSDRSDAENNEEASNSILKPLISPAAERIRFILGEDDDSPAPPQLFTELDELLSVDGQEMEWKETARWIKFEEKVEKGGERWSKPHVATLSLHSLFELRTCIEKGTIMLDLEASTLPGVVEMITDSQIESGLLKADLKEKVMYTLLRKHRHQTKKSNLRSLADIGKTVSSASSPTTAHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDSPFVAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHEIAYKAKDRQDLLAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYAGGDSTQMNGDTPHSGGHGGGGHAVGDELKKTGKFCGGLILDVKRKVPFFFSDFYDSLHIQSLSAILFIYLGTVTNAITFGGLLGDATENMQGVLESFLGTAVTGAVFCLLAGQPLIILSSTGPVLVFERLLFNFSRENDFDYLEFRLWIGLWSAFFCLVLVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMLKLAHYYPINSDFKIDYVTQYDCMCMAPTDANSSDVYTDPLDSTFVWTVNYTTDPRMNATWSSLSKKECLKYGGELVGKACEFVPDITLMSFILFFGTYTCSMCLKKFKTSPFFPTTVRKLISDFAIILAILIFCGVDALVGVETPKLIVPSEFKPTSPNRGWFVPPFGGNPWWVYLGASVPALLVTILLFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAVLLAVCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGVMVFILTGISVFMSPVLKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPAKHQPDLIYLRHVPLRKVHLFTFVQLLCLALLWVLKSTVAAIIFPVMILALVAVRKALDYIFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKQGSIDSDMEDSDYPYNENVPSIKIPMDMMEQEPFLGDKASDREKSASILDRYSSC
Protein: anthranilate synthase (EC 4.1.3.27) (F4IAW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAASTLYKSCLLQPKSGSTTRRLNPSLVNPLTNPTRVSVLGKSRRDVFAKASIEMAESNSIPSVVVNSSKQHGPIIVIDNYDSFTYNLCQYKQNFENCYLFLQYMGELGCHFEVYRNDELTVEELKKKNPRGVLISPGPGTPQDSGISLQTVLELGPLVPLFGVCMGLQCIGEAFGGKIVRSPFGVMHGKSSMVHYDEKGEEGLFSGLSNPFIVGRYHSLVIEKDTFPSDELEVTAWTEDGLVMAARHRKYKHIQGVQFHPESIITTEGKTIVRNFIKIVEKKESEKLT
Protein: AT3g56820/T8M16_150 (RmlC-type cupin) (Q94EG4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein LOL1
Sequence:
MANPRRVVIENQRLSPLINLLKKPQAIPLLLSLFLLLTWISLRLQHSSQSHVSSSSSHPKSTVNSHPDLKVYDDDDKANLVRFGLASLSPARKDDRGWLLDPVILARDSELKGGAASCVSIHVGEIRPGGLRGNHRHHTCNETFVIWGAKTKFRLENHEVDKGYAEVLIGEDEVAVAVSQSGTAHALVNVDPVRSTFFIGCQDHMQNNSSTSDYKVWNDL
Protein: SPbeta prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) (O34919)
Organism: Bacillus subtilis (strain 168)
Function: Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP, so that uracil cannot be incorporated into DNA. The Ser-62 side chain changes its position upon ligand-binding to make contacts with the nucleotide phosphates.
Interaction partners:
- Thymidylate synthase 1
- Thymidylate synthase 2
- Thymidine kinase
- Ribonucleoside-diphosphate reductase NrdEB subunit alpha
- Nucleoside diphosphate kinase
- Thymidylate kinase
- ComE operon protein 2
- Deoxyuridine 5'-triphosphate nucleotidohydrolase YncF
- Trifunctional nucleotide phosphoesterase protein YfkN
- SPbeta prophage-derived ribonucleoside-diphosphate reductase subunit beta
Sequence:
MQIKIKYLDETQTRINKMEQGDWIDLRAAEDVAIKKDEFKLVPLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDTKIKKGDRICQFRIMKKMPAVDLIEVDRLGNGDRGGHGSTGTK
Protein: Auxin-responsive protein (A0A2H1ZEF6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004549}.
Interaction partners:
Sequence:
MSPEEYVRVWPDSGDLGGTELTLALPGTPTNASEGPKKFGNKRRFLETVDLKLGEAHENNYISSMVTNDQLVGWPPVATARKTVRRKYVKVALDGAAYLRKVDLGMYDCYGQLFTALENMFQGIITICK