wanglab/gogpt-training-data huggingface dataset:
Protein: Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2) (Q9Y6X8)
Organism: Homo sapiens (Human)
Function: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12741956, ECO:0000269|PubMed:17056598}. Note=Colocalizes with EFNB1 intracellular domain in the nucleus. {ECO:0000250|UniProtKB:Q8C0C0}.
Interaction partners:
- Zinc finger and BTB domain-containing protein 20
- TBC1 domain family member 31
- Alpha-fetoprotein
- Mitoferrin-1
- Ephrin-B1
- GTPase HRas
Sequence:
MASKRKSTTPCMVRTSQVVEQDVPEEVDRAKEKGIGTPQPDVAKDSWAAELENSSKENEVIEVKSMGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIETTNHVVSITTSGPGTGDSDSGISVSKTPIMKPGKPKADAKKVPKKPEEITPENHVEGTARLVTDTAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLAPTKVTQPILQTALPCQILGQTSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDVGAPNGALSRLDQLSGAQLTSSLPSPSPAIAKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTVKWMEQYQHQPMADDHGYDAVARKATKPMAESPKNGGDVVPQYYKDPKKLCEEDLEKLVTRVKVGSEPAKDCLPAKPSEATSDRSEGSSRDGQGSDENEESSVVDYVEVTVGEEDAISDRSDSWSQAAAEGVSELAESDSDCVPAEAGQA
Protein: L-fuculokinase (EC 2.7.1.51) (L-fuculose kinase) (P11553)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the phosphorylation of L-fuculose. Can also phosphorylate, with lower efficiency, D-ribulose, D-xylulose and D-fructose.
Interaction partners:
- L-fucose isomerase
- L-fuculose phosphate aldolase
- L-fucose mutarotase
- L-fucose operon activator
- L-fucose-proton symporter
- Lactaldehyde reductase
- L-rhamnose isomerase
Sequence:
MKQEVILVLDCGATNVRAIAVNRQGKIVARASTPNASDIAMENNTWHQWSLDAILQRFADCCRQINSELTECHIRGIAVTTFGVDGALVDKQGNLLYPIISWKCPRTAAVMDNIERLISAQRLQAISGVGAFSFNTLYKLVWLKENHPQLLERAHAWLFISSLINHRLTGEFTTDITMAGTSQMLDIQQRDFSPQILQATGIPRRLFPRLVEAGEQIGTLQNSAAAMLGLPVGIPVISAGHDTQFALFGAGAEQNEPVLSSGTWEILMVRSAQVDTSLLSQYAGSTCELDSQAGLYNPGMQWLASGVLEWVRKLFWTAETPWQMLIEEARLIAPGADGVKMQCDLLSCQNAGWQGVTLNTTRGHFYRAALEGLTAQLQRNLQMLEKIGHFKASELLLVGGGSRNTLWNQIKANMLDIPVKVLDDAETTVAGAALFGWYGVGEFNSPEEARAQIHYQYRYFYPQTEPEFIEEV
Protein: Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (P19491)
Organism: Rattus norvegicus (Rat)
Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P42262}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42262}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42262}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42262}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P23819}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23819}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (PubMed:19265014). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). {ECO:0000250|UniProtKB:P23819, ECO:0000269|PubMed:19265014}.
Interaction partners:
- Glutamate receptor 4
- Voltage-dependent calcium channel gamma-8 subunit
- Voltage-dependent calcium channel gamma-2 subunit
- PRKCA-binding protein
- Glutamate receptor 3
- Glutamate receptor 1
- Protein cornichon homolog 2
- Glutamate receptor-interacting protein 1
- Protein cornichon homolog 3
- Voltage-dependent calcium channel gamma-4 subunit
Sequence:
MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI
Protein: ABC-type dipeptide transport system, solute-binding protein (Orf15) (Q8KRB4)
Organism: Streptomyces clavuligerus
Interaction partners:
- DUF482 domain-containing protein
- ABC-type dipeptide transport system, periplasmic component
- Biotin carboxylase
- Oligopeptide transport system integral membrane protein
- Oligopeptide transport integral membrane protein
- BldKC, ABC transport system integral membrane protein
- Acetyltransferase GNAT family protein
- ABC transporter system integral membrane protein
- ABC transporter system integral membrane protein
- BldKA, ABC transport system integral membrane protein
Sequence:
MTTAARRPAPTTAGAGWDAGVGALVNPSRRRGGTLRLVSSADVDSLDPARTYYVWVWLLQRLLNRTLMAYPTDPGPAGLVPAPDLAEGPGEVSDGGRTWTYRLRRGLRYDDGTPITSDDVRHAVQRVFAQDVLPGGPTYLIPLLDDPERPYPGPYRTDEPLRSVLTPDEHTIVFRLTRPFSDFDHLMAQPCAAPVPRRSDTGADYGRDPRSSGPYRVARHEPDTLLHLERNPHWDRATDPIRPALPDRVELTIGLDVDVLDARLIAGEFDINLEGRGLQHAAQRRATADEVLRSHTDNPRTSFLHFVAMQPHIPPFDNVHVRRAVQYAADKILLQDARGGPVNGGDLTTALFPPTLPAHQDLDLYPTGPDLRGDLDAARAELAAAGLPDGFRAVIGTQRGKFRLVADAVVESLARVGIELTVKELDVATYFSLGAGHPETVREHGLGLLVTDWGADFPTEYGFLAPLVDGRQIKRNGGNWNLPELDDPEVNALIDETLHTTDPAARAELWRAVERRVMEHAVLLPLVHDKTLHFRNPWVTNVYVHPAFGLYDIQAMGLAEED
Protein: Euchromatic histone lysine methyltransferase 1 (A0A0D9SFS4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTP
Protein: Multifunctional methyltransferase subunit TRM112 homolog B (Multifunctional methyltransferase subunit TRM112-like protein At1g78190) (Protein SMALL ORGAN 2-LIKE) (tRNA methyltransferase 112 homolog B) (AtTRM112b) (Q9C9R3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as an activator of both rRNA/tRNA and protein methyltransferases (By similarity). Required for TRM9 tRNA methyltransferase activity.
Interaction partners:
- tRNA
- tRNA
- AT3g13440/MRP15_7
- 18S rRNA
- At5g64156
- tRNA wybutosine-synthesizing protein 2/3/4
- Alkylated DNA repair protein ALKBH8 homolog
- Methyltransferase-like protein 5
- Phosphatidylinositol N-acetyglucosaminlytransferase subunit P-like protein
- Bystin
Sequence:
MRLIVHNMLSCNIKGVVNKFPLRIEAEKVTVKEVDFNPDFLRYMFAKIDWKALVDGARSMEYTELPDNAPDTTTLESDETFLRKFHHALLELHLEEGSLVCPETGRKFSVSKGIPNMLLHEDEV
Protein: diguanylate cyclase (EC 2.7.7.65) (Q8EBG2)
Organism: Shewanella oneidensis (strain ATCC 700550 / JCM 31522 / CIP 106686 / LMG 19005 / NCIMB 14063 / MR-1)
Interaction partners:
- Bifunctional diguanylate cyclase/phosphodiesterase with PAS sensory domain
- Two component signal transduction system response regulator with cyclic diguanylate phosphodiesterase activity and PAS sensory domain
- Bifunctional diguanylate cyclase/phosphodiesterase with GAF and PAS sensory domains
- Bifunctional diguanylate cyclase/phosphodiesterase
- Signalling protein with GGDEF and EAL domains MshH
- Bifunctional diguanylate cyclase/phosphodiesterase LasD-like protein
- cyclic-guanylate-specific phosphodiesterase
- Bifunctional diguanylate cyclase/phosphodiesterase
- Signalling protein with EAL and C2 domains
- Signalling protein with EAL domain
Sequence:
MKLRDNFKRKTIDRLDYRYHLLLLIIPIVLFVLLFVFNAPTEGWTILPLLFVCLIYVVTYSLIYYLHQGRLTRLWQHLEQVVSINDAIYELAHLSSQYKNEHAFLDALLNKAVCIINGAEMGSIIKVSEDNHKLHFESVVGLDLNKLKRLNFSLEQSFEYRLTKGKCDRVVVVDDMKNINAASTLTNEQQQVLLTAAKQPIRSTLSSPIRIDGKLYGMLNLDSSSVGAFNDYDRNLVSILTHEASNAIALYQKSLQITKLANFDNLTGLYNRKNFEDALQHWQPKAHLGSFLVIIDMDNLKIINDQQGHQVGDVAIKEVAKTILGFWKHKGIISRFGGDEFVALCHGPLELIENDLDAMRLKLHHESPLNLNFSVGIAPYDNDWAKSFKQADNAMYEQKRGKKQAVNALKAIVANNQLPQ
Protein: Vacuolar membrane-associated protein IML1 (Increased minichromosome loss protein 1) (SEH-associated protein 1) (P47170)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:21454883}; Peripheral membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:21454883}.
Interaction partners:
- SEH-associated protein 4
- Protein transport protein SEC13
- Maintenance of telomere capping protein 5
- Nitrogen permease regulator 3
- Nitrogen permease regulator 2
- Restriction of telomere capping protein 1
- Nucleoporin SEH1
- GTP-binding protein GTR1
- GTP-binding protein GTR2
- Mitochondrial inner membrane protease subunit 1
Sequence:
MFAKLHGKKQRPISSINSQTPRTSNTTHANSISLSSGNLIVGSNRNLRQKKEQFGSQQRASGRKLISNKENDDNVNNGGDNNYDNGERVHRHHIPGLKIKAYQAELGYHESRFSENLVMLNLVEFPDIKPGDLVELKTYHKNPSASNGDKKIYFIAKDFDGETKRRAKTSNVSILSGQLQTLLDLPSRSRIWIKLKPNKFDLQADVVEFNIKDCLLNRGDMWVLSSKLVDTCVFMDQRLAFLDSIRGTIKGIYRNGKKIVSGYIGEQTRIIFRSESARLIFLIQITDEMWNFEETGEQLFQKMVNSFFPKIFKKWKDVDTHHTITIAFAISMDLSDTSFKDLTPGESLKNSQDYFRIVVDQVSIIHWVDIMETLREEFMEIRKDLLNKQTDKGYSVANGRFSPVIKSNFLELVNFATTILTDPFKQLDLRHTTTHVMIISPGSGLFDVDYSLLRLTGKKLLSLEMTMDLICLSKAPLHIVPLFRYRDFENKLHHCVPLWLSVFFWNDHDKKSNSEWTPRCKIYDLQMMGITENELIREVDVEYLQLNKKVKSLSEFMNDYDKNAFEVKILCAGSNTKQSKKLNSKFDTVFENDVVVKARKIPATATTTHGNTKFIWRGPKVALPAIKDIQKPNVIPDLSIKTIEASFYDDCNTTNDKISTPTTSNNDNLEMNDSLVSVRSADNQNTSLALDSLKGLSKRNSLKDFTQRVITKFISNIDTSKNKKIKSTLLRDDVDNSPLGSNTPLPSSESKISGLKLQQKGLADENVISKRGNLIIKKNLSIFGLPSNEIMSGSPSSYLGSSHTRTSSKLSNMSDKAAFITEGQKSKHDDSNTYSLTQQLKHRISETWVDIKSPSIPVSSEFANELLPIRWKDVWPKYVARKYSKWRSFTTPAELPITISDFPSKDDFDRNFIFRNHSVTLNTDQEQYNQTYKDLLRDMIYMRLLTGFQICVGRQVEKIELSRESGESETVVNKYLDFNQNDAFKLYLMIDSEIHRITCSSSGIIDVERYLRKDEANLFDQVPSYIPLVKTRYESSFRDAMIDPLHVKRESLNWNQIDQVLAGYGDNLIDRKWHGFRAKYVVLPTDIPPNTYSMVINGKSETLNPEEIRVEGLRRLIGSITRSRLRTEKEKKGRKTKREEIQPEVMFYTGPLYNFINEQQTSLESSAINFKDSIFVNDNNLLNRNVELSKLAYQIQRGEDRITLVNRKWHWKKHEKCFVGSEMVNWLIRNFSDIDTREDAIKYGQKVMKEGLFVHVLNKHNFLDGHYFYQFSPEYVMDTNKLEKTNSHRSTLSDPKQMLRKASTGSSNDPSAMTPFSSVVPAISASNASVADAKEPSRPILMLSNSLVIDVDPAGKSSKQESCTVHYDRVHNPDHCFHIRLEWLTTTPKLIDDLVGNWSRLCERYGLKMIEIPWEELCTIPSVNPFHSFVEIKLAINPWEDPEFKDRELFAKSKFYYHVYLLKASGFLLDNRASKFLQNQDIEFDIMYSWGKPQFKYVQYIHHTGAYVAELRENGCLFLAPNNIYISRVNPGNIIGKIHSASSSSLDAQKVILNFKSTCLDYQKLRSIFLDAKEMWITGKIVED
Protein: SH3 domain-containing YSC84-like protein 1 (O08641)
Organism: Mus musculus (Mouse)
Interaction partners:
- Actin nucleation-promoting factor WAS
- Actin nucleation-promoting factor WASL
- Mevalonate kinase
Sequence:
MNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGKWSAPSAIGIAGLGGGFEIGIEVSDLVIILNYDRAVEAFAKGGNLTLGGNFTVAVGPLGRNLEGNVSLRSSAAVFTYCKSRGLFAGISLEGSCLIERKETNRKFYCQDIRAYDILFGDVPQPAQAEDLYEILNSFTEKYETEGQRINLKKVAREQRKAKELPPKPSSRPQPAHPPVQLNAGSQGNRNEYKLYPELSSYHEKTGNLNQPIEVTALYSFEGQQPGDLNFQAGDRIIVISKTDSNFDWWEGKLRGQTGIFPANYVTMN
Protein: Neuropeptide S (P0C0P8)
Organism: Mus musculus (Mouse)
Function: May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.
Subcellular location: Secreted.
Interaction partners:
- Neuropeptide S receptor
- Hypocretin neuropeptide precursor
- Corticotropin-releasing factor receptor 1
- Neuromedin-S
- Neuromedin-U
- Oxytocin-neurophysin 1
- Relaxin-3
- Neuromedin-U receptor 2
Sequence:
MIGSLKLSFVLALSLSVMHVLWCYPVLSSKVPGKPDYFLILLSSCPARLEGSDRLAFLKPILEKTSMKRSFRNGVGSGAKKTSFRRAKQ
Protein: Mitochondrial carrier protein MTM1 (Manganese tracking factor for mitochondrial SOD2) (Q944H5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the mitochondrial activation of MSD1 by specifically facilitating insertion of the essential manganese cofactor. Has the ability to activate iron regulon in an iron-dependent manner.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:17522887}; Multi-pass membrane protein {ECO:0000269|PubMed:17522887}.
Interaction partners:
- Phosphatidylinositol-3-phosphatase myotubularin-1
- At5g43150
- Phosphatidylglycerophosphate phosphatase PTPMT2
- Probable protein phosphatase 2C 10
- Protein S40-2
- acid phosphatase
- Metal ion-binding protein
- Inositol diphosphatase DSP4
- Dual specificity protein phosphatase PHS1
- Inositol diphosphatase DSP2
Sequence:
MVEAERAENSWIASETSPSSSPVVIESSDFSITDGMRDVSGFGIASRPQLDKGLSENNIGFTERVFSAAGAAVLSAVTLNPLDVVKTRLQAQAAGMSYSHPLSNSIGRMAFFGPNMMFADLRCSPSCARAGVEGTVSICPPDCFQYKGTFDVFTKIIRQEGLGRLWRGTNAGLALAVPMVGIYLPFYDMFRNRLEELSREKAPAMTFCVPTVAGSLARSLACTVCYPIDLARTRMQAFKEAKAGVKPPGVFKTLVGVFSEVRTANNLESSLHNYRGLWRGLGAQLARDVPFSAICWSTLEPIKKRLLGVAGNDTNLVGVFGATFSAGFIAGSIAAAATCPLDVARTRRQIEKDPGRALMMTTRQTLIEVWRDGGMRGLFMGMGPRVARAGPSVGIVVSFYEVVKYVLHRHASS
Protein: Translin-associated protein X homolog (O74955)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Translin-1
- Protein argonaute
- Pre-mRNA-splicing factor srp1
Sequence:
MEEEFLSFKNFLQEDQDKREKIIRLSREITIQSKRMIFLLHQTSSSDGFPLPKDFDRTSIFEKKIHKELESLKRELAGLNADKFSSACTHGLQEYVEAVTFKFWLQTGTLLSCKDSSFRISINFIDYVLGVCDMTGEIMRFLVTNGSKFSVQQLTQQVKFLRGLHKNCSEIEHLPSKVKSELQQKLSVMENSISKVEGICYSKILREADKRYLNLEVDTATPPEEKRLRST
Protein: Uncharacterized protein C24B10.06 (Q9P7J9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
Sequence:
MFGKVSSLLVFASFLIIQGAFATLVAPIGDLEHLSEIELLYTNRVLPSKIPLTPFVKRDDDSSSTQASYSTTVSDVVIVTDKSWSDGVETIFPYSYTEYQPSTTYTSAPAGSIGYAASIPNTGRELMESGSPVRFSKSSLLIVSLLSIAAFAALVL
Protein: Rho-related GTP-binding protein RhoN (Rho family GTPase 2) (Rho-related GTP-binding protein Rho7) (Rnd2) (Q9QYM5)
Organism: Mus musculus (Mouse)
Function: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome. {ECO:0000250|UniProtKB:P52198}.
Interaction partners:
- Plexin-B1
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
- Rho GTPase-activating protein 35
- Intersectin-2
- Intersectin-1
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
- Plexin-D1
Sequence:
MEGQSGRCKIVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENYTASFEIDKRRIELNMWDTSGSSYYDNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQGETQEFCPNAKVVLVGCKLDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVECSSRSSERSVRDVFHVATVASLGRGHRQLRRTDSRRGLQRSTQLSGRPDRGNEGEMHKDRAKSCNLM
Protein: PiggyBac transposable element-derived protein 3 (Q8N328)
Organism: Homo sapiens (Human)
Function: Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.
Subcellular location: Nucleus {ECO:0000269|PubMed:26218421}.
Interaction partners:
Sequence:
MPRTLSLHEITDLLETDDSIEASAIVIQPPENATAPVSDEESGDEEGGTINNLPGSLLHTAAYLIQDGSDAESDSDDPSYAPKDDSPDEVPSTFTVQQPPPSRRRKMTKILCKWKKADLTVQPVAGRVTAPPNDFFTVMRTPTEILELFLDDEVIELIVKYSNLYACSKGVHLGLTSSEFKCFLGIIFLSGYVSVPRRRMFWEQRTDVHNVLVSAAMRRDRFETIFSNLHVADNANLDPVDKFSKLRPLISKLNERCMKFVPNETYFSFDEFMVPYFGRHGCKQFIRGKPIRFGYKFWCGATCLGYICWFQPYQGKNPNTKHEEYGVGASLVLQFSEALTEAHPGQYHFVFNNFFTSIALLDKLSSMGHQATGTVRKDHIDRVPLESDVALKKKERGTFDYRIDGKGNIVCRWNDNSVVTVASSGAGIHPLCLVSRYSQKLKKKIQVQQPNMIKVYNQFMGGVDRADENIDKYRASIRGKKWYSSPLLFCFELVLQNAWQLHKTYDEKPVDFLEFRRRVVCHYLETHGHPPEPGQKGRPQKRNIDSRYDGINHVIVKQGKQTRCAECHKNTTFRCEKCDVALHVKCSVEYHTE
Protein: ATP-dependent DNA helicase PriA (EC 5.6.2.4) (DNA 3'-5' helicase PriA) (Helicase PriA) (Replication restart primosome protein PriA) (Q5F6V8)
Organism: Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Interaction partners:
- Single-stranded DNA-binding protein
Sequence:
MIYHRIAVNVPLSDGLLTYSHSEPLPPGTRVLVPFRNKTVVGMVWETDIAPDMDAARILSVQTVFVEEKPLSQSWRDLLAFTSRYYHYPTGQAVFAALPQGLKETRAVEMPQPPLFYALNEAGRAQTPPPARFNKKAALWDALLSGEMTMAALKQANAQAAKLIEDWAEQGWIETTEAAKPVLRPYRGQASHSEFVLNTGQQKASDEIQTALGRFRSFLLYGITGSGKTEVYFDAMAKVLAQGRQVLFLLPEINLTPQLLKRVENRFADVPTAVLHSRMAAGRRTQDYLRAMLGQAKLVIGTRLAVFTPLPDVGLIVVDEEHDGSFKQDNELRYHARDLAVWRAKQGGCPVVLGSATPSLESWHKAQSGAYRLLQLTERAHASAQLPQVDILNIGRLKLDNGFSPQALQLLKQNFEAGGMSLVYLNRRGFAPALFCGDCGHTFGCPNCSAKMVLHQRARQLRCHHCDHREPIPFKCPDCGNQDLTAVGHGTQRVEETLRAFLPKAAVVRVDRDSTAHKNDWADLYRRIANDEIDILVGTQMLAKGHDFARLNLVIVLNADGSLYSADFRAPERLFAELMQVSGRAGRADKPGKVLIQTQLPEHPVFAAVKAQDYAVFAENELNERQMFAMPPFGFQTAVRADAPRVADAMEFLNAAKETLAPLLPESVSRFGAAPMLMVRLAERERAQVFLESTSRQDLHRAVSLWVQVLQQNRDGKIRWSVDVDPQEA
Protein: Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489) (Q6U7Q0)
Organism: Homo sapiens (Human)
Function: Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15555580}. Nucleus {ECO:0000269|PubMed:15555580}. Note=Mainly found in the nucleus. {ECO:0000269|PubMed:15555580}.
Interaction partners:
Sequence:
MYTSEEKCNQRTQKRKIYNVCPRKGKKIFIHMHEIIQIDGHIYQCLECKQNFCENLALIMCERTHTGEKPYKCDMCEKTFVQSSDLTSHQRIHNYEKPYKCSKCEKSFWHHLALSGHQRTHAGKKFYTCDICGKNFGQSSDLLVHQRSHTGEKPYLCSECDKCFSRSTNLIRHRRTHTGEKPFKCLECEKAFSGKSDLISHQRTHTGERPYKCNKCEKSYRHRSAFIVHKRVHTGEKPYKCGACEKCFGQKSDLIVHQRVHTGEKPYKCLECMRSFTRSANLIRHQATHTHTFKCLEYEKSFNCSSDLIVHQRIHMEEKPHQWSACESGFLLGMDFVAQQKMRTQTEELHYKYTVCDKSFHQSSALLQHQTVHIGEKPFVCNVSEKGLELSPPHASEASQMS
Protein: (+)-3-carene synthase 1, chloroplastic (EC 4.2.3.107) ((+)-car-3-ene synthase 1) (3-carene cyclase 1) (Terpene synthase TPS-3car1) (PsTPS-3car1) (F1CKI6)
Organism: Picea sitchensis (Sitka spruce) (Pinus sitchensis)
Function: Terpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores (e.g. insect attack by white pine weevil P.strobi) and pathogens. Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (+)-car-3-ene.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
Sequence:
MSVISIVPLASKPCLYKSFISSTHEPKALRRPISTVGLCRRAKSVTASMSMSSSTALSDDGVQRRIGNHHSNLWDDNFIQSLSSPYGASSYAERAERLIGEVKEIFNRISMANGELVSHVDDLLQHLSMVDNVERLGIDRHFQTEIKVSLDYVYSYWSEKGIGPGRDIVCADLNTTALGFRLLRLHGYTMFPDVFEQFKDQMGRIACSTNQTERQISSILNLFRASLIAFPWEKVMEEAEIFSTAYLKEALQTIPVSSLSREIQYVLDYRWHSDLPRLETRTYIDILRENATNETLDMKTEKLLELAKVEFNIFNSLQQNELKCVSRWWKESGSPDLTFIRHRQVEFYTLVSGIDMEPKRSTFRINFVKICHFVTILDDMYDTFGTIDELRLFTAAVKRWDKSATECLPEYMKGVYIDLYETVNELAREAYKSQGRDTLNYARQALEDYLGSYLKEAEWISTGYIPTFEEYLVNGKVSSAHRIATLQPILMLDVPFPPHVLQEIDFPSKFNDLAGSILRLRGDTRCYQNDRARGEEASCISCYMKDNPGSTEEDALNHINGMIEKQIKELNWELLKPDKNVPISSKKHAFNISRGLHHFYKYRDGYTVANSETRNLVIKTVLEPVPM
Protein: Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) (Antisense basic fibroblast growth factor) (Protein GFG) (P53370)
Organism: Homo sapiens (Human)
Function: May contribute to the regulation of cell proliferation.
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms.
Interaction partners:
- Hepatoma-derived growth factor
Sequence:
MRQPLSWGRWRAMLARTYGPGPSAGYRWASGAQGYVRNPPVGACDLQGELDRFGGISVRLARLDALDRLDAAAFQKGLQAAVQQWRSEGRTAVWLHIPILQSRFIAPAASLGFCFHHAESDSSTLTLWLREGPSRLPGYASHQVGVAGAVFDESTRKILVVQDRNKLKNMWKFPGGLSEPEEDIGDTAVREVFEETGIKSEFRSVLSIRQQHTNPGAFGKSDMYIICRLKPYSFTINFCQEECLRCEWMDLNDLAKTENTTPITSRVARLLLYGYREGFDKIDLTVEELPAVYTGLFYKLYHKELPENYKTMKGID