wanglab/gogpt-training-data huggingface dataset:
Protein: Glycosyltransferase family 32 protein (G8BJ74)
Organism: Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
Interaction partners:
- Uncharacterized protein
- Vanadate resistance protein
- Alpha-1,6-mannosyltransferase MNN10
- Alpha-1,6-mannosyltransferase
- Mannan polymerase II complex ANP1 subunit
- Alpha-1,2-mannosyltransferase
- Nucleoporin NSP1-like C-terminal domain-containing protein
- Uncharacterized protein
- Alpha-1,2-mannosyltransferase
- Uncharacterized protein
Sequence:
MGRRNYKTAFVTGFLLLVVYFFYFSFNGHAAYKTEPNSNKLQLIRELEANKEWKTRGFNFQPKLKPTPEQSSKVLQELYHSIPYDPTSDFPKFIWQTWKVALSDESFPKRYRNFQKTWDDKNPNYKHFVISDAQCDALVAELYAEAPDVAKAYSVMPKSILKADFFRYLILFARGGVYTDIDTVGLKPIDEWASNNEEIAGKTNNAGLVVGIEADPDRPDWADWYARRIQFCQWTIQSKRGHPMLAQLIAKITDITLTRSAKGQLKKILGKDEGGDIMNWTGPGIFTDYVFKYLNQVVEVDWRLFTGMEQPIAIDDVLVLPITSFSPDVNQMGAKSSGDPMAFAKHMFSGSWKDDGMPEMLT
Protein: Tribbles homolog 2 (TRB-2) (Q8K4K3)
Organism: Mus musculus (Mouse)
Function: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=May associate with the cytoskeleton. {ECO:0000250}.
Interaction partners:
- RIB43A-like with coiled-coils protein 2
- E3 ubiquitin-protein ligase COP1
- E3 ubiquitin-protein ligase TRIM21
- CCAAT/enhancer-binding protein alpha
Sequence:
MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFEISCYQESLAPCFCLSAHSNINQITEILLGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSGFGAKEACDQLVPDVNMEENLDPFFN
Protein: PSP1 C-terminal domain-containing protein (Q383I5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MCVYDKQQRNNLHIQVSITKEREGRVNEIGLSRLGKKFKKEVRSRQACNVCVRNRGKSEVKKGAYGGGKKNYIYTYHLETPHIMSTTCTKNEPRGFHHDPYGTPLLDQGSEERKNNAALNFFTAATYADEHQKQEQYSLTNFDTLSSVDQMTSTEGEGGISDNGTVESSGPFVVTPVPQPTSTVALAMASSTVIAAAASVVRYASVDFRFGSAWFVAPFRTSVGEIVVVEYPHNGSLHVGLVSCITTTIPPTFTTLRAAEQAGLMPTEEDLMQYPRLVRHAREFDRHTKLELRTHDLASLRSARELAEEMGAPITFIDAEWLLDLTAVTFLVQVWGNMEQVDRLADELAAREGAEVVFTYPAVRYE
Protein: Double-stranded RNA-binding protein Staufen homolog 2 (r-staufen protein) (Q68SB1)
Organism: Rattus norvegicus (Rat)
Function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body.
Subcellular location: Nucleus, nucleolus. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and may require the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted.
Interaction partners:
- Polyadenylate-binding protein 1
- Y-box-binding protein 1
- Heterogeneous nuclear ribonucleoprotein A3
- Type A/B hnRNP p40.
- Heat shock cognate 71 kDa protein
- Cytoplasmic polyadenylation element binding protein 2
- U6 snRNA-associated Sm-like protein LSm1
- Regulator of nonsense transcripts 1
- Fragile X messenger ribonucleoprotein 1
- Endoribonuclease Dicer
Sequence:
MANPKEKTPMCLVNELARFHSIQPQYKLLNESGPAHSKMFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKPFPNYRANYNFRGMYNQRYHCPMPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPEKSPQNGESGKEMDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLPPLPVIEKPKLFFKKRPKTIIKAGPEYGQGMNPISRLAQIQQARKEKEPDYVLLSERGMPRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLGYKASTSLQDQLDKTGENKGWSGPKPGFPEPANNTPKGILHLSPDVYQEMEASRHRVTSGTTLGYLSPKDMNQPSSSFFSVESPSPTSSAPAARELLMNGTSPAAEAIGLKGSSPTPPCSSVQPSKQLEYLARIQGFQAALSALKQFSEQGLESIDGVVNVENGSLEKQAKHLREKADNNQANPGSITQDCKKSKSVI
Protein: Phage tubulin-like protein (PhuZ) (EC 3.6.5.-) (Phage tubulin/FtsZ) (Tubulin-like protein TubZ) (B3FK34)
Organism: Pseudomonas phage 201phi2-1 (Pseudomonas chlororaphis phage 201phi2-1)
Function: A tubulin-like GTPase that forms filaments, which are required for positioning viral DNA and capsids in the middle of the host cell for optimal replication. The motor component of a partition system which pushes phage DNA (encased by protein gp105) to the center of the bacterial host cell. Also required for movement of phage capsids to the vicinity of the viral DNA and rotation of the encased viral DNA at midcell. Forms filaments during the lytic phase, which position phage DNA at the center of the bacterial host cell. Filaments have a three-stranded intertwined achitecture and form a spindle-like cytoskeleton within the infected cell. Has GTPase activity. Filaments grow at the plus end and depolymerize at the minus end, a process called treadmilling, and switch from growing in a polar manner to catastrophic depolymerization, i.e. they display dynamic instability, like tubulin. In infected host cells the filament ends close to the cell pole are relatively stable, while the other end near the phage DNA is highly dynamic. Both capsid movement and DNA rotation probably require treadmilling (Probable).
Subcellular location: Host cytoplasm {ECO:0000269|PubMed:22726436, ECO:0000269|PubMed:25429514}. Note=In infected host cells forms a spindle-like structure emanating from each cell pole. {ECO:0000269|PubMed:24631461, ECO:0000269|PubMed:25429514, ECO:0000269|PubMed:28813669}.
Interaction partners:
Sequence:
MPVKVCLIFAGGTGMNVATKLVDLGEAVHCFDTCDKNVVDVHRSVNVTLTKGTRGAGGNRKVILPLVRPQIPALMDTIPEADFYIVCYSLGGGSGSVLGPLITGQLADRKASFVSFVVGAMESTDNLGNDIDTMKTLEAIAVNKHLPIVVNYVPNTQGRSYESINDEIAEKIRKVVLLVNQNHGRLDVHDVANWVRFTDKHNYLIPQVCELHIETTRKDAENVPEAISQLSLYLDPSKEVAFGTPIYRKVGIMKVDDLDVTDDQIHFVINSVGVVEIMKTITDSKLEMTRQQSKFTQRNPIIDADDNVDEDGMVV
Protein: Protein DSS1 HOMOLOG ON CHROMOSOME V (AtDSS1(V)) (Probable 26S proteasome complex subunit sem1-2) (Q9FL96)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (By similarity). Associates also with the TREX-2 complex that is required for transcription-coupled mRNA export.
Interaction partners:
- Protein BREAST CANCER SUSCEPTIBILITY 2 homolog B
- Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A
- 26S proteasome non-ATPase regulatory subunit 3 homolog B
- 26S proteasome non-ATPase regulatory subunit 3 homolog A
- SAC3 family protein C
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome non-ATPase regulatory subunit 11 homolog
- SAC3 family protein B
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- SAC3 family protein A
Sequence:
MAAEPKAAVEVVKVDLFEDDDEFEEFEINEDWLEKEEVKEVSLQWEDDWDDDDVSDDFSRQLKKELENASEKK
Protein: Megakaryocyte and platelet inhibitory receptor G6b (Protein G6b) (O95866)
Organism: Homo sapiens (Human)
Function: Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner.
Subcellular location: [Isoform E]: Endoplasmic reticulum {ECO:0000269|PubMed:11544253}. Golgi apparatus {ECO:0000269|PubMed:11544253}.; SUBCELLULAR LOCATION: [Isoform D]: Endoplasmic reticulum {ECO:0000269|PubMed:11544253}. Golgi apparatus {ECO:0000269|PubMed:11544253}.; SUBCELLULAR LOCATION: [Isoform B]: Cell membrane {ECO:0000269|PubMed:11544253}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform A]: Cell membrane {ECO:0000269|PubMed:11544253}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- Tyrosine-protein phosphatase non-receptor type 11
- Platelet glycoprotein VI
- Tyrosine-protein phosphatase non-receptor type 6
- C-type lectin domain family 1 member B
Sequence:
MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRFAPLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV
Protein: Glutamate receptor ionotropic, NMDA 2D (GluN2D) (EB11) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D) (O15399)
Organism: Homo sapiens (Human)
Function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:9489750}; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Interaction partners:
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 3A
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor ionotropic, NMDA 3B
- Disks large homolog 4
- Proenkephalin-B
- Nitric oxide synthase 1
- P2X purinoceptor 6
Sequence:
MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLESEV
Protein: Galanin receptor 1a (Galanin receptor type 1) (F1QSA8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Galanin peptides
- Galanin peptides-like precursor
- Spexin prohormone 1
- Pro-opiomelanocortin protein
Sequence:
MGTQNNSDLDRPRSNIDLEAPEKNLFGIGTDNLVTLLIFGLIFTLGVLGNSLVITVLAQRKPGQQRSTTNIFILNLSVADLSYLLFCIPFQSTVYMLPTWILGAFICKFIHYFFTVSMLVSIFTLSAMSVDRYIAIVHCRKSSSIRVARHALIGVLVIWVLSFAMATPVAYYQGIVESEDNSTFCWEVWPDHDRRKIYVVCTFVFGYVLPLILISFCYAKVLNHLHKKLRNVSKKSEASKKKTAQTVLVVVVVFCLSWLPHHVVHLWVEFGSFPLNQASFVLRVAAHCLAYSNSSVNPVIYAFLSENFRQAYKQVFRCQVASECPTNEAREMKSKTEAAPSTNCTTV
Protein: FI23547p1 (Mutagen-sensitive 201, isoform C) (Mutagen-sensitive 201, isoform D) (Nucleotide excision repair protein MUS201) (Q4U2Q5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- General transcription factor IIH subunit 1
- DNA repair endonuclease XPF
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription and DNA repair factor IIH helicase subunit XPD
- DNA excision repair protein ERCC-1
- Serine/threonine-protein kinase ATR
- Crossover junction endonuclease MUS81
- RING-type E3 ubiquitin transferase
- Proliferating cell nuclear antigen
- DNA polymerase theta
Sequence:
MGVTGLWKLIEPCGKPVPVETLEGKILAVDISIWLHQVVKGFQDNKGSALSNAHLLGLFHRLCKLLYYRVRPVFIFDGCVPQLKRDTIARRQQQRNKLSNEADRIQALLLQSLAKEKVVQQALGKNAELLLKSPVKRPPPAKKNDEDDLFKLPELPAASVQDNQDESEQDTSASASDSSFDESTARHSYNSSLQAIDVKSQHFRNLPADVRHEILTDIKETRKQSSWGRLHELPARSDDFCSFQMKRLLKRRAVQESLEQAEQEMGGHTLTYAELCDFFNEEGILTPTAIEQCTRQISSDEHTRFLLVRDLKKKAMESTKQEVKMEMIEEVPAEEEDEKPSTSTKKEAVKSVDLGTEFDEDLAKALSMSMEETKVYDEKDYEYDSDQELRLNRAQTKQLRHAAKGPARAYMIEYGGMNDEEVGNIMEATQFNDTQSLEKLLEITTVPTDMADNSIEEAKLISQAIEESKQLSQAIEESKKNLNEDKVEIVDTDTDSDLEEVMEVQELDKGKKNLEICVDITGQADSNDLFADIFEDGEANKIEKTISVEEDDDFIEVKDSEELKLDTEDENKPITNKSIKESNEVKPFIDEIIEVKDSQEAVPAEPNLKPDLESILNDLKKQTAAVKDIQLNVNEEEKPKPKVEISSILDELKVKMADVKNITLDNVKLSNSVPIILSSDDESTLKSSKIVPKQELIELCDSDDNKNNRLSPNKTPSKNKSIKDFFETSYVVKRTPDKSQASNETSPGTPKTPKPFFRKRTPKSGRKRASDANEDSDEEVSPTKRSSKASKSLFEPKEPEEEKTVDPEEIIKDAAEALKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVAPMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFRAEQIEQTFNCNRGKLIQLACLVGSDYTTGIHGIGAVTALEILASFSGQDANGPGICNQSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYLAPTIDDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAKSALRVQQPHVSKRVQLAIDKMSGKIDETPEKPKKVTRTRRAKAAPPTDDDLAIADVATKAARPKRGKRKAAPESVVLDGELPSTSQSIPKPEKCPRIPSSVEVIPQREKDLEQMRLNKAKAAEILKNSAKANRK
Protein: Photosystem I assembly protein Ycf4 (Q6ENG3)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: Seems to be required for the assembly of the photosystem I complex.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00437}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00437}.
Interaction partners:
- Cytochrome b559 subunit alpha
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein K
- Photosystem II reaction center protein H
- Photosystem II CP47 reaction center protein
- Photosystem II D2 protein
- photosystem II
- Photosystem I P700 chlorophyll a apoprotein A1
- Photosystem I P700 chlorophyll a apoprotein A2
- Photosystem I iron-sulfur center
Sequence:
MNWRSEHIWIELLKGSRKRGNFFWACILFLGSLGFLAVGASSYLGKNIISVLPSQQILFFPQGVVMSFYGIAGLFISAYLWCTILWNVGSGYDRFDRKEGVVCIFRWGFPGIKRRVFLRFLMRDIQSIRIQVKEGLFPRRILYMEIRGQGAIPLTRTDEKFFTPREIEQKAAELAYFLRIPMEVF
Protein: IQ motif and SEC7 domain-containing protein 3 (Q3TES0)
Organism: Mus musculus (Mouse)
Function: Acts as a guanine nucleotide exchange factor (GEF) for ARF1.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UPP2}. Postsynaptic density {ECO:0000269|PubMed:27609886}.
Interaction partners:
- Gephyrin
- Rho guanine nucleotide exchange factor 9
- Inhibitory synaptic factor 1
- ADP-ribosylation factor 6
Sequence:
MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLLQAQPPPGLVPPPPSAPLPAPAVTAPAAAAAQEPLQDHGQLIPASPEPPLQHHGQLLAQPQPAPSSRVQTPQSPHQHPVAPGAIADKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPENETVLHQFCCPAADTEQKPACSDLASQSDGSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGRQQPALATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRAPTAESLVAEKALLEGCGLLGLPLGRSPSLPPTFAGSLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAAAREPESGPGSGDEAGGLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTAQATAEPAAAQAEQEDTADQEVSEVPASEQMDPPSEDSEAAESRAQSAQEPAVAQAVVEEAVATEAEEEEEGAKQAGKGAEAEGGDNSEQLSSSSASTKSAKSSSEASAAASKEALQAVILSLPRYHCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSVRSAGAQGDPQSKQGSPTAKREAMAGEKAAESSGEVSIHNRLQTSQHSPKLGVERGAPAPSPPTSPPPLPPDPQPSPLREQPPPLPLPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYASSSSDSCGSTPLRGPGSPVKVIHQPPLPPPPPPYNHPHQFCPPGSMLLRRRYSSGSRSLV
Protein: Lysosomal cholesterol signaling protein (LYCHOS) (G-protein coupled receptor PGR22) (Q7Z3F1)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:36007018}; Multi-pass membrane protein {ECO:0000269|PubMed:39358511}.
Interaction partners:
Sequence:
MNSNLPAENLTIAVNMTKTLPTAVTHGFNSTNDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKWKDTQNASQNKIKIVGLGLLRVLQNPIVFMVFIGIAFNFILDRKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSFDISIVSLISLIWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGISLMCMNQTAQAGSYEGFDQSQSHKVVEPGNTAFEESPAPVNEPELFTSSIPETSCCSCSMGNGELHCPSIEPIANTSTSEPVIPSFEKNNHCVSRCNSQSCILAQEEEQYLQSGDQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKDTAENRDSPVSEEIKMTCQQFIHYHRDLCIRNIVKERRCGAKTSAGTFCGCDLVSWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPAINANTLQQERYKEIEHSSPPSHSPKT
Protein: Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form] (Q07537)
Organism: Bos taurus (Bovine)
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (By similarity).
Subcellular location: [Polypeptide N-acetylgalactosaminyltransferase 1]: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Polypeptide N-acetylgalactosaminyltransferase 1 soluble form]: Secreted {ECO:0000250}.
Interaction partners:
- Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- Hexosyltransferase
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- C1GALT1-specific chaperone 1
Sequence:
MRKFAYCKVVLATSLIWVLLDMFLLLYFSECNKCDEKKERGLPAGDVLEPVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMLEEIVLVDDASERDFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCECTVGWLEPLLARIKHDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRLGLRHKLQCRPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVGIFNCHGMGGNQVFSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATDEDSQVPSIRDCSGSRSQQWLLRNVTLPEIF
Protein: Probable glutathione S-transferase 7 (EC 2.5.1.18) (GST class-sigma) (P91253)
Organism: Caenorhabditis elegans
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection.
Interaction partners:
- Glutathione S-transferase P 10
- Glutamate--cysteine ligase
- Glutathione S-transferase P
- glutathione transferase
- Glutathione S-transferase omega
- Probable glutathione transferase omega-2
- Alcohol dehydrogenase class-3
- Glutathione synthetase
- Glutathione transferase omega-1
- Glutathione S-transferase
Sequence:
MVHYKVSYFPIRGAGEIARQILAYAGQDFEDNRIPKEEWPAVKPSTPFGQLPLLEVDGKVLAQSHAIARYLARQFGINGKCAWEEAQVNSVADQFKDYLNEVRPYFMVKMGFAEGDLDALAKDVFLPGFKKHYGFFANFLKSAGSGYLVGDSLTFVDLLVAQHTADLLAANAALLDEFPQFKAHQEKVHSNANIKKWLETRPVTPF
Protein: Protein transport protein Sec61 subunit beta (P60468)
Organism: Homo sapiens (Human)
Function: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:27044890}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- Protein transport protein Sec61 subunit gamma
- Protein transport protein Sec61 subunit alpha isoform 1
- Protein transport protein Sec61 subunit alpha isoform 2
- Translocation protein SEC63 homolog
- Translocon-associated protein subunit beta
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
- Translocon-associated protein subunit delta
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Translocon-associated protein subunit gamma
- Translocation protein SEC62
Sequence:
MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
Protein: Invariant surface glycoprotein, putative (Q57VX4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSTMPVTLRTTATVFLLCGICALDVTLAADLPLTSRQFVTNGRMLDGRGALTLCEMKKTLDGVNSRVDTFEQQILTFVNNANANFRKISDDKVMAASLSASRLQEMQYMKSLGNSIIKYMGGTGERAKAAAANASAALDQVLTWHCVDRTASHESSYSSTPNANCEPNAYKRDYYYEHSRLDPHKYSILCNYKVVSSTTTQTTFSNMERALEIWNQVKPKPYSARVMICGAGAPAHQAAPAGRPCTVLENWVRDYRVTAHLIAKLEKDATLALRVMRYSEKVLEGDKESLAQHEERRKAAEARAAEEEAKRQAAEKAAEEARKALEEAEARRVAAEEQAEARRLEAEKAEKAKEAGQPVSEEKKKMLLEAVEEAEATEKAAEKQAKDSRKAFEEAEEERVKATEDAEAAKEEKEDAGRSEEELKKSLEKLAEELKEESKESGEEDDVNADHDDEGSEAKSGWIGTTKVLIFLIPLLLLLLGLLVFFVIRGRRKAEVKDDINIEEGGAKSKNTKTAAGLDSDI
Protein: Phosphodiesterase (EC 3.1.4.-) (A0A0S2Z4A3)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
Protein: Osiris 23 (Q9VA75)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Osiris 13
- Osiris 4, isoform B
- Osiris 21
- Osiris 1
- FI07663p
- Osiris 10a
Sequence:
MRVPSVLVTFLLGVILVDRYAAGEDLADKSWISQMKKLRSDLRDCYQSGIHQSLWSCFRSRSLHIFEGIMSSPEISIYDGVRLVAAPNSTDNATRPDDERKDLKHLTWFDQLAVSLAKGLTTHTLQVNLGKLTERYLSSDTSNPDPVGSARVRRHRYNMIITMMFGVTALGAILVPMGFQMLSIVSGKALLLAKMALLLASINGLKRVANNGLHYGLYHVPGEHLGGYYDRGDVSHPRNVPIPVAVAPTLDMGLK