Protein: CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Q8K389)
Organism: Mus musculus (Mouse)
Function: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis. Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, does not interact with EB1/MAPRE1, therefore its function in the regulation of microtubule dynamics is unclear.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20466722, ECO:0000269|PubMed:20471352, ECO:0000269|PubMed:20627074, ECO:0000305|PubMed:19553473}. Golgi apparatus {ECO:0000250|UniProtKB:Q96SN8}. Cytoplasm {ECO:0000250|UniProtKB:Q96SN8}. Note=Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Due to the lack of interaction with EB1/MAPRE1, its localization to microtubule plus ends may not be conserved in mice (Probable). Localization to centrosomes versus Golgi apparatus may be cell type-dependent (By similarity). {ECO:0000250|UniProtKB:Q96SN8, ECO:0000305|PubMed:19553473}.
Interaction partners:
- Pericentrin
- Serine/threonine-protein kinase PLK1
- Protein NEDD1
- Centrosomal protein of 152 kDa
- Gamma-tubulin complex component 6
- Tubulin gamma-1 chain
- Gamma-tubulin complex component 5
- Centrosomal P4.1-associated protein
- Mitotic-spindle organizing protein 1
- Mitotic-spindle organizing protein 2
Sequence:
MDSGMEEEGALPGTLSGCSGLHPVLPSDLDVISDTSGLGNGVLPSMSEEKVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERIQQEFAGPTEHIYKTNIELKVEVESLKRELQEKDQLLVKASKAVESLAERGGSEVQRVKEDARKKVQQVEDLLTKRIHLLEEDVKAAQAELEKAFAGTETEKALRLSLESKLSAMKKMQEGDLEMTLALEEKDRLIEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELRGLSATLREEKERDAEEWQKERNHFEERIQALQEDLREKEREIATEKKNNLKSYKAIQGLTMALKSKEREVEELDSKIKEVTTDSTKGREDPLKTQIPRFQLREGSEDCEAALVEKEALLAKLHSENVTKSTENHRLLRNVKKVTQELNDLKKEKLRLEQALEEAHQEGNRGARTIHDLRNEVEKLRKEVSEREKAVEKHYKSLPGESKTKFHTQEQVVRSLTGSGSQEDLLLQKSNEKDLEAIQQNCYLMTAEELKFGSDGLITEKCSQQSPDSKLIFSKEKQQSEYEGLTGDLKAEQNIYAHLAKTQDTDSVSNLQAELKEVLALRKQLEQDVLAYRNLQKALQEQLSEIRSREEEPFSFYSDQTSYLSICLEEHNQFQLEHFSQEELKKKVSDLIQLVKDLHTDNQHLKKTIFDLSSVGFQGSDRLELTKQEELVASKEDEDTLKFEADVETPFQSDQHLEQSREIMEDYAEGGCKSGYGRHMDSNILGHDGAQTPGASEEHTLEDELLGLLATLFSKKATPLLESRPDLLKALGALLLERICLAEQGRPGDHLDSKTEKALQQVAVQLRDELGHSFPANSFSKSYNEVKSMWGNWLVKTGDEDTVELKSVSVQTMAIEDTPHGFKPQSKRDAWAEKQEEAIFSTELESEALGEMPGQQATHLSFPSAINPDAEKTGLLIQLKTPELLENLYNLPASPEVVVAQLQGQVLELQRELKEFKTRNKQLHEKLILAEAMMEGLPVPNSALVNVPAAQAVVRTAFQDNPGEQEGPETTQSAGRDKDMDSDQYTSFEIDSEICPPDDLALLPACKENLEDLLGPSSIATYLDSKSQLSVKVSVNGTDQSENINIPDDTEDLKQKIHDLQTELEGYRNIIVQLLKHSQCSEAIITVLCGTEGAQDGLNKPKGHIDEEEMTFSSLHQVRYVKHMKILRPLTPEMIDGKMLESLKQQLVDQEQELQKEQDLNLELFGEIHDLQNKFQDLSPSRYDSLVQSQARELSLQRQQIKDSHGICVIYRQHMSTMIKAFEELLQASDVDSCVAEGFREQLTQCAGLLEQLERLFLHGKSARVEPHPQNELLKGLRTVEGNLPYHHLLPESPEPSASHALSDDEMSEKSFLSRDPKPDSDTEKYPAMASHFPQDLLMEHIQEIRTLRKHLEESIKTNEKLRKQLERQGSETDQGSRNVSACGLALHSSLTSEIHFLRKQNEALSMMLEKGSKDKQKESEKLRESLARKAESLEQLQLEYTSVREENERLQRDIIEKERHNQELTEEVCSSRQELSRVQEEAKSRQQLLSQKDKLLQSLQMELKVYEKLAEEHPRLQQDGSKCPEASDNSFDLFESTQAMAPKSASETPLLSGTDVDSLSCDSTSSATSPTSMPCLVAGHHMWASKSGHHMLGLIEDYDALYKQISWGQTLLAKMDVQTQEALSPTSHKLGPKGSSSVPLSKFLSSMNTAKLVLEKASRLLKLFWRVSVPTNGQCSLHCEQIGEMKAENTKLHKKLFEQEKKLQNTAKLLQQSKHQEKVIFDQLVITHQVLRKARGNLELRPGATRPGASSPSRPGS