wanglab/gogpt-training-data huggingface dataset:
Protein: FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) (Q7Z417)
Organism: Homo sapiens (Human)
Function: Binds RNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:12837692, ECO:0000269|PubMed:26184334}. Cytoplasm {ECO:0000269|PubMed:12837692, ECO:0000269|PubMed:26184334}. Cytoplasm, Stress granule {ECO:0000269|PubMed:26184334}. Note=Distribution is cell cycle-modulated, being cytoplasmic in the G2/M phase and accumulating in nucleus during the G1 phase (PubMed:12837692). {ECO:0000269|PubMed:12837692, ECO:0000269|PubMed:26184334}.
Interaction partners:
- Fragile X messenger ribonucleoprotein 1
- FMR1-interacting protein NUFIP1
- Ras GTPase-activating protein-binding protein 2
- Ras GTPase-activating protein-binding protein 1
- Protein FAM98A
- Ataxin-2-like protein
- RNA-binding protein FXR2
- Probable ATP-dependent RNA helicase DDX6
- RNA-binding protein FXR1
- Roquin-1
Sequence:
MEEKPGQPQPQHHHSHHHPHHHPQQQQQQPHHHHHYYFYNHSHNHHHHHHHQQPHQYLQHGAEGSPKAQPKPLKHEQKHTLQQHQETPKKKTGYGELNGNAGEREISLKNLSSDEATNPISRVLNGNQQVVDTSLKQTVKANTFGKAGIKTKNFIQKNSMDKKNGKSYENKSGENQSVDKSDTIPIPNGVVTNNSGYITNGYMGKGADNDGSGSESGYTTPKKRKARRNSAKGCENLNIVQDKIMQQETSVPTLKQGLETFKPDYSEQKGNRVDGSKPIWKYETGPGGTSRGKPAVGDMLRKSSDSKPGVSSKKFDDRPKGKHASAVASKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKTIQNSSVSPTSSSSSSSSTGETQTQSSSRLSQVPMSALKSVTSANFSNGPVLAGTDGNVYPPGGQPLLTTAANTLTPISSGTDSVLQDMSLTSAAVEQIKTSLFIYPSNMQTMLLSTAQVDLPSQTDQQNLGDIFQNQWGLSFINEPSAGPETVTGKSSEHKVMEVTFQGEYPATLVSQGAEIIPSGTEHPVFPKAYELEKRTSPQVLGSILKSGTTSESGALSLEPSHIGDLQKADTSSQGALVFLSKDYEIESQNPLASPTNTLLGSAKEQRYQRGLERNDSWGSFDLRAAIVYHTKEMESIWNLQKQDPKRIITYNEAMDSPDQ
Protein: Malic enzyme (Q9NIW2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGNSSSICADRNVITNFDENGTPVYPTANNSQSPSSYSRGKERELGCYTKRNSNSNNNNSHERESQSCCSSRVCKNHTTTTTTTLEYELSNFAKLTTRITTQSAAEVDTSPHTDTETHRDRDSNPGNIALATDLELPKGLPLSLSSRHHWNQLQSSLHALHHQQQQQQQQLRSYSSTSETNLEDKMSKPDSKLDKYAQRDRLGLWGTGDNEVVGSLSGFTRLLDKRYSKGLAFTHEERQQLGIHGMLPYVVREPSEQVEHCRALLARLDQDLDKYMYLISLSERNERLFYNVLSSDIGYMMPLVYTPTVGLACQRYSLIHQNAKGMFISIKDKGHIYDVLKNWPETDVRAIVVTDGERILGLGDLGANGMGIPVGKLSLYTALAGIKPSQCLPITLDVGTNTESILEDPLYIGLRERRATGDLYDEFIDEFMHACVRRFGQNCLIQFEDFANANAFRLLSKYRDSFCTFNDDIQGTASVAVAGLLASLKIKKTQLKDNTLLFLGAGEAALGIANLCLMAMKVEGLTEEEAKARIWMVDSRGVITRDRPKGGLTEHKLHFAQLHEPIDTLAEAVRKVRPNVLIGAAAQGGAFNQEILELMADINETPIIFALSNPTSKAECTAEEAYTYTKGRCIFASGSPFAPVTYNNKKFYPGQGNNSYIFPGVALGVLCAGMLNIPEQVFLVAAERLAELVSKDDLAKGSLYPPLSSIVSCSMAIAERIVEYAYKNGLATVRPEPVNKLAFIKAQMYDLDYPRSVPATYKM
Protein: Glycine betaine/proline betaine transport system permease protein ProW (P14176)
Organism: Escherichia coli (strain K12)
Function: Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for the translocation of the substrate across the membrane (Probable).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Glycine betaine/proline betaine-binding periplasmic protein
- Glycine betaine/proline betaine transport system ATP-binding protein ProV
- Glycine betaine-binding protein YehZ
- Glycine betaine uptake system ATP-binding protein YehX
- Spermidine/putrescine transport system permease protein PotC
- Iron
- Spermidine/putrescine import ATP-binding protein PotA
- sn-glycerol-3-phosphate transport system permease protein UgpA
- Spermidine/putrescine transport system permease protein PotB
- sn-glycerol-3-phosphate transport system permease protein UgpE
Sequence:
MADQNNPWDTTPAADSAAQSADAWGTPTTAPTDGGGADWLTSTPAPNVEHFNILDPFHKTLIPLDSWVTEGIDWVVTHFRPVFQGVRVPVDYILNGFQQLLLGMPAPVAIIVFALIAWQISGVGMGVATLVSLIAIGAIGAWSQAMVTLALVLTALLFCIVIGLPLGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTIIFALPPIIRLTILGINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLRGIGRLDMGLATVGGVGIVILAIILDRLTQAVGRDSRSRGNRRWYTTGPVGLLTRPFIK
Protein: LD08354p (Q8MSY2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKEEDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVETTTEGTDSQAVSAAPPSKKTKKDKKKK
Protein: Proline rich 13 (F8VU40)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MWNPNAGQPGPNPYPPNIGCPGGSNPAHPPPINPPFPPGPCPPPPGAPHGNPAFPPGGPPHPVPQPGYPGCQPLGPYPPPYPPPAPGIPPVNPLAPGMVGPAVIVDKKMQKKMKKAHKKMHKHQKHHKYHKHGKVSTLWRLAREGVPPQRD
Protein: Multifunctional non-homologous end joining protein LigD (NHEJ DNA polymerase) [Includes: DNA repair polymerase (Pol) (Polymerase/primase); 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase) (PE); DNA ligase (Lig) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])] (A0R3R7)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang DNA double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ during 3'-overhang repair. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. Acts as a DNA ligase on singly nicked dsDNA, as a DNA-directed DNA polymerase on 5' overhangs, and adds non-templated nucleotides to 3' overhangs (terminal transferase). Fills in gaps in dsDNA, prefers a 5'-phosphate in the gap. Site-directed mutations leading to ligase loss alter the bias from insertion to deletion mutations, and indicate another ligase (LigC1 and/or LigC2) can compensate.
Interaction partners:
- Non-homologous end joining protein Ku
- DNA ligase A])
- DNA ligase B
- DNA polymerase I
- Beta sliding clamp
- Protein RecA
- 5'-3' exonuclease
- Antigen 34 kDa
- DNA polymerase IV
- DNA polymerase IV
Sequence:
MARHPWGMERYERVRLTNPDKVLYPATGTTKAEVFDYYLSIAQVMVPHIAGRPVTRKRWPNGVAEEAFFEKQLASSAPSWLERGSITHKSGTTTYPIINTREGLAWVAQQASLEVHVPQWRFEDGDQGPATRIVFDLDPGEGVTMTQLCEIAHEVRALMTDLDLETYPLTSGSKGLHLYVPLAEPISSRGASVLARRVAQQLEQAMPKLVTATMTKSLRAGKVFLDWSQNNAAKTTIAPYSLRGRDHPTVAAPRTWDEIADPELRHLRFDEVLDRLDEYGDLLAPLDADAPIADKLTTYRSMRDASKTPEPVPKEIPKTGNNDKFVIQEHHARRLHYDLRLERDGVLVSFAVPKNLPETTAENRLAVHTEDHPIEYLAFHGSIPKGEYGAGDMVIWDSGSYETEKFRVPEELDNPDDSHGEIIVTLHGEKVDGRYALIQTKGKNWLAHRMKDQKNARPEDFAPMLATEGSVAKYKAKQWAFEGKWDGYRVIIDADHGQLQIRSRTGREVTGEYPQFKALAADLAEHHVVLDGEAVALDESGVPSFGQMQNRARSTRVEFWAFDILWLDGRSLLRAKYSDRRKILEALADGGGLIVPDQLPGDGPEAMEHVRKKRFEGVVAKKWDSTYQPGRRSSSWIKDKIWNTQEVVIGGWRQGEGGRSSGIGALVLGIPGPEGLQFVGRVGTGFTEKELSKLKDMLKPLHTDESPFNAPLPKVDARGVTFVRPELVGEVRYSERTSDGRLRQPSWRGLRPDKTPDEVVWE
Protein: Aminopeptidase (H2L0M5)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSATFKSMAPICEGEPCIRNGSGAAATVHFRQESRRRKSDFARKCIAVILLHAIFLLAILAALIIGHWISEENQKLSNRTMLNITLAEAYLLEGIYTTSTATPESLSHHHTHLLTTSSAALGQSKKKTPPRVVERLIPLEKKRNFTISDVFPPPADGGFGIAEQLHAVRANKLSTDALLVPLPLYILPYHYDLQLDFSQFDTHLFIRANISIHLESYGNSTEDEIQFHLGPNIKMERMRLRKDGKKFYAKTFKREESKKLGRISLRDPLQKGKYILEMTYNMTICDEDVDGVRCSLDNQTNSSLKATSFTTKFEPTLARAFFPCWDEPGVKATFNISVRHNKKYTVLSNMPPVESHDHKSWEDQFKTTVFQTTPPMSTYLLAFAIGEFVKLESRTERGIPVTVWTYPEDVMSMKFTLEYAPVIFDRLEDALEIPYPLPKVDLIAARNFHVGGMENWGLVVFEFASIAYTPPITDHVNETVDRMYNEFRIGKLIAHEAAHQWFGNLVTMRDWSELFLNEGFATFYVYEMMSTERPVTAQFEYYDSLASLILAQSEEDHRLSLVRELATESQVESSFHPTNLYTKGCVLIRMLRDLVSDFDFKAAVRRYLRKNAYRSVSRDDLFASLPAYADHGAEQEKLSHVLEGWFVNEGIPEITLIRNYDNEMMTISQRKTVHHEYRSFLKDRKASASVRYRGSRSAEDGSTLFDDALFDGYIEKKKDRRRKHRPIRRKTSTPPSISPISRRDELRKPRRVGASQDLWTIPITYMFGSLKTSEGQVIREFWLKNRTVSFGDAEISPNQAVLVNPEWKYPYRVNYDLLNWKLLARTLHQNHLEINEKSRMQLILDAEYFLSNSVNPHLYLYLLGYLAHETKMEVMLFGIDAVYKFIDVYKATQLNKAILVYFEPVISQMDHLLNESQVDAETASLWLVRPERLAKLYQMRCAAGLSSCKNDYYTQRWSRSPDEWTEDVHKQVTAVCHQLFTNTPDEVKTVQDLLDSRLQSSGAKWALTVQLAACSHDQKLLRRTARAIVSTKNAVVYASALQSDFSLHYNPTFRKYLWAEIAKMSTFEKTALFSTNSTDILPASRILLHSVKTIDELQQIRGLLTNWGPLLSLHFEYLERYLLWVSSVSQGVLHQFFAADLSNF
Protein: MutT/nudix family protein (A0A0H2URA0)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MKTSDFVKYLQRMIAITDTGLTFTKDPFDRERYEDLRSLLSEMLNQASDLDSEEVAEVLKPTSAYATPLMDVRAWIVEDEKICLVRGQGEDSWALPGGFGEVGYSPTENILKEIEEETGFKAKVERLLAVFDTNRFQLQSKQYTKFVFGCKLLDGQFQENQEIADLQFFAIDQLPNLSEKRITKEQIELLWQVYQGHRGQYLD
Protein: Zinc finger protein GLI1 (Glioma-associated oncogene homolog) (P47806)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P08151}. Nucleus {ECO:0000250|UniProtKB:P08151}. Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1. {ECO:0000250|UniProtKB:P08151}.
Interaction partners:
- Suppressor of fused homolog
- Kinesin-like protein KIF7
- Zinc finger protein GLI2
- F-box/WD repeat-containing protein 1A
- Protein smoothened
- Kinesin-like protein KIF3A
- Protein patched homolog 1
- F-box/WD repeat-containing protein 11
- Sonic hedgehog protein
- cAMP-dependent protein kinase catalytic subunit alpha
Sequence:
MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNMAVGNMSVLLGSLPGETQFLNSSA
Protein: 3-oxoacyl-[acyl-carrier-protein] (Q8XTB9)
Organism: Ralstonia nicotianae (strain ATCC BAA-1114 / GMI1000) (Ralstonia solanacearum)
Interaction partners:
- Malonyl CoA-acyl carrier protein transacylase
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
- Enoyl-[acyl-carrier-protein] reductase
- Phosphate acyltransferase
- Probable non ribosomal peptide synthetase protein
- Amp-dependent synthetase or ligase protein
- Acyl-coenzyme a synthetases/amp-
- Probable polyketide synthase protein
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Sequence:
MHDVVISGTGLWVAPEVITNAELVASFNAYARRYNEANADAIAAGELAAVAESSVEFIEKASGIRQRYVIDKAGVLDPARMRPRLAPRGDDTLSLQAEIGVAAAREALAAAGREAADIDMLICSAANMQRPYPAMGIEIQNALGAGGYAFDMNVACSSATFGLEQAVNAVRTGSARMALMVNPEITSGHLAWQDRDCHFIFGDVCTAVVVERADDARARDQWHVLGTRMATRFSNSIRNNAGFLSRSEDRHPDDRDQLFRQEGRKVFKEVCPMAAEHIAGHLQALGHAPADVRRFWLHQANLGMNQLIGKRLLGRDATADDAPVILDEFANTASAGSIIAFHRHRGDLRPGDLGVICSFGAGYSIGSVAVRKR
Protein: Glutamate--isopropylamine ligase (EC 6.3.2.-) (Gamma-glutamylisopropylamide synthetase) (GIPA synthetase) (Q936T0)
Organism: Pseudomonas sp
Function: Involved in the degradation of isopropylamine, which is a constituent of the herbicides atrazine. Catalyzes the ATP-dependent formation of gamma-glutamyl-isopropylamide from isopropylamine and L-glutamate. It can also use aminoalkanes, amino-alcohols (L-alaninol and D-alaninol) and amino-esters as substrates.
Interaction partners:
Sequence:
MSEENKKQILKVRDFIEKHNIDTIRLGAVDIDGVWRGKQVGAEYFLNKAALDGTQISNILFGWDVADHLVDGLEFTGWDSGYPDIALIPDLSTLSLVPWQEKTASVLCDIQHLNGEPLNLSPRNLLRKAIEKAEQLGYKCYAAYEFEFYLLNDSIASISADQWRSINPVEKSGHCYSMLHHSSSSDIMGEVRKYMRDAGIVLEATNSEHGPGQYEINIKYDDALKAADDAIFVKNGIKEIAAKHGMTATFMAKPSAEWSGSSGHVHMSLSDLAGTPVFANPENPGALSEVGYNFLAGMVALAREMSAIYLPNINSYKRTAGASWAGGNSSWGFDNRTVSHRAITSAGSAARVENRIPGADTNPYLVIAASLLSGLYGIENKLKPKDPILGNAYKVSPELARPLAASLEEAAGIFRESEMARVIFPNEFVEHYAQMKVWEIKQSNSFVNNWELARYLDII
Protein: CB1 cannabinoid receptor (Q8QGC7)
Organism: Gallus gallus (Chicken)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}. Presynapse {ECO:0000256|ARBA:ARBA00034106}.
Interaction partners:
Sequence:
YHFIGSLAVADLLGSVIFAYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCVMWTIAIVIAVLPLLGWNCKKLNSVCSDIFPLIDETYLMFWIGVTSILLLFIVYAYMYILWKAHSHAVRMLQRGTQKSIIIQSTEDGKVQITRPDQTRMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTIFAFCSMLC
Protein: CAP, isoform P (B7YZE0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPNNRNRNRNRNRNKRNRNQNQNQNPSQNQNENHQQQAEGAEDREEQQDFQTQIAVAQSSSFVDDNGNSGSVSNGPTENSEEVTNTLEKTEKKEEIFEQPATVIQKEADSDAEMGAKNSKHRKEKSDKQASNGKSEEQVRPPPTIIRRPPGSPRQAKVIVHRIVREEDTANGKAQSPEPPKAVESKEQHMEVEDSKKEKPEAQQEIETKEERENEPSPKELPESSHLSEDAQQKHVEVEENQQVYDEVDYSKDETTDNNPQQEQHDSKEPEQYVLQLEKAMEFVENAHQQHVAAVQSYQKQRDTEQNAQQQEQNEAQHLQESTKAHQQNIAVPQILVDPKKREEGLAQQLHHDVKEEPILNNAQQQNDDTAPKSPKEVTIKVQFQTEDPYSQQPPPQKPTSKVIIHQIHVETTDEEQNAKPTFEEVSSTTGSLAGTLSPPPRYLVESPKNVSSGQFSNFSRNVQIQEMELNSDFSSGEFNSLQSPLVCEVDSESEGSVVLGPERSPSDQQVPSSSRVEQHEQVRQKRAQYRNALESHFMPQLLNPRYLDSILEENEWRNSTASSGGSDQTGIRTPKLNETFPRSQLDFSRRHKRREEAPSPLKLETKLLEESTDLESCTRLQSALSPQSEDAELVYLSSSASSSVSDLMELELEQAAALAERALVDLDTDASRLIARPDDEMSSTSTTTADRSETEAETETETEREGEQSRESTPVNANPTLASSQSSLLSAATPTPTPTPTPADREQLAKDTNVSGGSTVSFGAASPLAATREEFVRNMDKVRELIEMTRREQEQGELPRSPSPPPVPPPPASVPPYSPESSSFHLASLQLKRQESNDSHCSDSTTHSQCTAINLASPPPPPTAQPPTPPLRQKPAPPPVPQPVSPPAPPTPQSEPELSVADSVANANADVDADADTDTEAIKKLRLLCTEQLASMPYGEQVLEELASVAQNISDQSQNKMPYPMPQLPHIKELQLNANESKSSSAWLGLPTQSDPKLLVCLSPGQRDLVNNQTQPDDLLDAHQKFVERRGYHELSKAQVLEQDHQQQQSEMLKTAAMMRELRKSLSPPAPPVPPPPVPVKSAETAAKATAHENAKRDDASEQKQKIAACESSSLENKPRRAADLGAQQSAEQRQSSSTTTSSHKATTETMSSDTAKFPTLDSMESELARMFPQHKGDIFEEQRKRFSNIEFPSHQPVSQTKRYSNIETSSYESKKRMENGQVVYDVSTSSHEKKEQGDPPKDQPVPPVPPPPIMSATKLNGNTFIDGDVAPKNSQPSRESGSGSGNGTYEEFRQRAKAAADAFGEQREQQNGLDQDRVFKDFDRLSQQMHAELQSTREKREKSASMYDLSGFTRPASGHPRLDELQQRRHAHMQELEREIERSAKSRQERMSSVPRQMEATPPRTHEIPIELEPRSRRAESLCNLNEPPPRPHTTVGHYNHPVVQDDWSRYANDLGYSENIARPFAREVEICYQRQNQRTPHCIRAPRLSASTNDLSSSSQYSYDTFNAYGGRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSRRGVSPAPPPVATPQQQQVPPPAYDRQQRRSSLPRELHEQQLKYILSKEEELKFEVERLQQERRRLMEEMQRAPVLPAPQRRESYRPAAKLPTLSEDEVFRQQMAEEWMNKVAEREERRQHKIIRISKIEDEHDHSAVDKATISDEFLDRVKERRHKLSMPADSDWESGAESQPQPAAQSQPESDVEAPPVRILEGQAEANLRQLPRHLREFAKFSTSEQLPDGAQMERHEEQERREEATDNAHSSATKKTSIVKTYKVSRLPPSVQDEATDSESRSTTIHQINRSSDPQPGKIGASLNEFFAGSPFRAKIYEEFDKYWRNFEHSASNTF
Protein: Serine/threonine-protein phosphatase (EC 3.1.3.16) (Q8SXA5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MMKKLLSNGSNKNKTLKFDEGINLDQIIAKLKLIGEIGSVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFANRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRPILSEQRRLSDISV
Protein: Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) (Q9VBX2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated Mocs2A into precursor Z to generate a dithiolene group.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03052}. Nucleus {ECO:0000269|PubMed:18327268}.
Interaction partners:
- SAGA-associated factor 29kDa
- Molybdopterin synthase sulfur carrier subunit
- Molybdenum cofactor synthesis protein cinnamon
- Molybdenum cofactor biosynthesis protein 1
- Adenylyltransferase and sulfurtransferase MOCS3
- Ada2a-containing complex component 2
- Ada2a-containing complex component 1
- DNA polymerase epsilon subunit 3
- Ubiquitin-like modifier-activating enzyme 5
- Protein Dr1
Sequence:
MDHVKLVNDPIDIAHIHQLLADEGCGASSVFVGTTRDNFQGKKVLSLAYEAYDSMALKEMNKICSDLRSKWLDLKHIVIYHRLGTVPVCEASVVIAASSPHRSEALESVSFAIDQLKTRVPIWKKEIYDGDNDSEWKENKESIRPKKSKSGFNYAACPCKVEESHDVPRTLVQIRVNDAELTKRLECFVNRKRDEINSQNVIDFKSSFVSSDQNLSDSCARTQSTIIKQEQSNCHLKVRRVNNRCGPQQMEMRPNYELELNKLMGSRDGQTDPTKEMRKSLPNSRLQAIESYMGLTTDNEENIFSRIKRVENRLLQLESISPEYRHFTKREPSSMEAAPPKKSRKKSYSAQELSAFIQKIKDGSELS
Protein: TMF-regulated nuclear protein 1 (Q80ZI1)
Organism: Mus musculus (Mouse)
Function: DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points.
Subcellular location: Nucleus {ECO:0000269|PubMed:23622239}.
Interaction partners:
Sequence:
MPGCRISACGPGAQEGTAEPGSPPPPPREPLPSLQPPSPSPTSTPTPTKSPPLPEAAETPVEGQELQRWRQGASGGSGGAGPAGIAGAAAGAGGRALELAEARRRLLEVEGRRRLVSELESRVLQLHRVFLAAELRLAHRAESLSRLSGGVAQAELYLAAHGSRLKKGARRGRRGRPPALLASALGLGSCVPWGAGRLRRGQGPEPDSPFRRSPPRGPASPQR
Protein: Transcription elongation factor SPT5 (A0A1W2Q6F0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR036945}.
Interaction partners:
Sequence:
MSDSEDSNFSEEEDSERSSEAEEAEVEEDRRSAAGSEKEEEPEEEEEEEEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKEREHNFQPGDNVEVCEGELINLQGKVLSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPRTVGVIVRLERETFQVLNMHGKVVTVRHQAVTQKKDNRFAVALDSDQNNIHVKDIVKVIDGPHSGREGEIRHLYRSFAFLHCKKLVENGGMFVCKARHLVLAGGSKPRDVTNLTVGGFTPMSPRISSPMHPSAEGQHGGFGSPGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVDSQRPGGMTSTYGRTPMYGSQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQIVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIIRMDLEDQQIKILNLRFLGKLLEA
Protein: Protein VHS2 (Viable in a HAL3 SIT4 background protein 2) (P40463)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Can suppress the synthetic lethality of the hal3 sit4 double mutation when overexpressed, suggesting that it is involved in the G1-S transition.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
Sequence:
MDTSNHNQDHDSHVAAQRENDNNYMPPSPSMSESSMIFERNVEDPSYLYKTVSNNAANSLSRQSSRTSLFNHNNSSNRNFHNLSQRSSAVNLHLQPSRTNESIASYQTYNPDFVVQTPLDHRRTLENFVPPALDAGCSIVTDDTTGLDDVDMVYSRRPSTIGLDRALGRTRSLSSQSFDNETSPAHPRSPNDHGSRLLRFYSYADMLSDDNNNNVSNATSTSSTANPLRRPPMQGHYSFSSSLLNSPSHLPSPPSASASPPQHMNFTNPFIISRRYSNTTINNANGGTSAGSTTGAALSRSPSNQQYLLKQQRSPSGSARSRRNSNRPGSAANIMIGKPKSKFHMESSGSEGFSSEEEDNTMIERDKLNLKQKLQSQLAQPPSIANMVNDNHNNTNKHKNTINNNIKNSPAFTNSNPSSKSNSNSTITSMNPDTTK
Protein: Methyltransferase (Q9LSI8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MAVLLSSFSPLGINIDMNKNLGVSYSSFPQIHLFKGSTPLRVRTFVVSSRKNSGTGLASEDKKLLLERYGYDANDDFGSQSKKARRKEEKMSGRNSQQVEEVVVVQPRTTHRLLQVLAGTAKRKKLLSLKGMDVRPMMEVVKGAAFGILQAAGGCPTSLRPGRWLDLYSGTGSVGIEAISRGCSEAHFVEMDPWVVSNVLQPNLEHTGFVDASVIHTARVENFLERADKLVGKDGVFDYISVTPPYMEVDYEVLMDQIAKSPAIGENTFILVEYPSRTTMLDSCGCLEKMTDRRFGRTHLAIYGPKWAQKPRKS
Protein: Osmotin-like pathognesis-related protein 5 (Q2HPG5)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
Sequence:
YTVWAAASPGGGRRLDPRQSWTINVPAGTAMARIWGRTNCNFDANGRGHCQTGDCGGLLECQGWGVPPNTLAEYSLNQFGNMDFYDISLIDGFNIPMVFGPTNGGCHNIRCTADLKGQCPNELRAPGGCNNPCTVFKTNEYCCTQGYGTCGPTYFSRFFKDRCHDSYSYPQDDPSSTFTCPAGSNYRVVFCPRGSPRIEMVGSKNQEK
Protein: CCHC-type domain-containing protein (O01489)
Organism: Caenorhabditis elegans
Interaction partners:
- Integrase zinc-binding domain-containing protein
- RRP15-like protein
- F-box domain-containing protein
- Nicotinamide N-methyltransferase
- Brix domain-containing protein
- Ovule protein
- Ribonuclease H2 subunit B wHTH domain-containing protein
- DUF2013 domain-containing protein
- Armadillo repeat-containing protein 1
- Zf-tcix domain-containing protein
Sequence:
MANANLTPMPFVRKFGSTSTTVTTTTDTDSPLSKDDESGKKPSLASLAQSAFPSRYDPNAFVDISGAAISAPAVTGACKRCGYPGHLYFQCRNHIEVRPNVSTKAYEVSSTSSESSDDETPLIALEKQRKKEKKLKKKAKKEKKKAKKLEKKERKKERKEKRRRRDDSDDSSDSDEEEDRKRKKSKESKKEKRKRRHSSSDDRSASSDSDDDCRDSKRHRRS
Protein: Angiopoietin-like 1 (Angiopoietin-related protein 1a precursor) (Q5KQU0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MRGVTWCMGTMLYLCISLLGKSHSGTELLHSRQRRAPADDSKKCSYTFLMPQQKITGPICASATGPEPDKDRVTRMDISDVREILSKQRREIEMLQLVADVDGNLVNEMKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELAQLENRVLNVTTEMLRLASRYKELEMRFAGLAGTVNNQSVLIAALEERCLRGYGRQDLPAVPPLVQVVPESIPANNNRFTNEIQRDNNNRAFPRGSRMDTPTPDPLGIPPPPQGTLTADGPFKDCSQVRQAGHSTSGMYLLKAEGSDRLIQAWCEHKLDNGGWTVFQRRKDGSVNFFRNWENYKKGFGNIDGEHWLGLENIYNLAKQGDYKLLVELEDWVGKKVYAEYSSFHLEPESEGFRLRLGTYQGNAGDSLTSHNGKPFTTLDRDKDAFTGNCAHFHKGGWWYNACGQTNLNGVWYSGGVYRSKFQDGIFWAEYGGGYYSLKSVRMMIRPID
Protein: Mucolipin TRP cation channel 1 (A0A8I6G3L4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004337}.
Interaction partners:
Sequence:
MMLPRTWAVETEQLLTPNPGYGTQAGTSPAPTTPPEEEDLRRRLKYFFMSPCDKFRAKGRKPCKLMLQVVKILVVTVQLILFGLSNQLVVTFREENTIAFRHLFLLGYSDGSDDTFAAYTREQLYQAIFYAVDQYLTLPEISLGRYAYVRGGGGPWANGSALALCQRYYHRGHVDPANDTFDIDPRVVTDCIQVDPPDRPPDIPSEDLDFLDGSTSYKNITLKFHKLINVTIHFQLKTINLQSLINNEIPDCYTFSILITFDNKAHSGRIPIRLETQTHIQECKHPSVSRHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVVFMWRRRGREISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVIRYLTFFHKYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGTGTEKSELQAYIEQCQDSPTSGKFRRGSGSTCSLLCCCGRNSPEDHSLLVN
Protein: eIF4E (Q9NB22)
Organism: Pisaster ochraceus (Ochre sea star) (Asterias ochracea)
Interaction partners:
Sequence:
ENESSSPALLQPEQEIKHPLQNKWALWFFKNDKAKSWADNLRVITAFDTVEDFWALFNHIQSASKLQSGCDYSLFKEGIKPMWEDDKNRKGGRWLLNLGRVKAQDVDRYWLESLLFLIGESCDDEGELVNGGVINVRSKGNKISVWTGNHKQEDGIMKIGKGFKATLNLPAKTLISYEAHADTMSKTGSMAKSRFVV