wanglab/gogpt-training-data huggingface dataset:
Protein: Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PsmB) (D4GYZ1)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The H.volcanii alpha1-beta proteasome is able to cleave oligopeptides after Phe, Tyr and Trp, poorly after Glu but not after Arg. Thus, displays chymotrypsin-like activity, low caspase-like activity but no trypsin-like activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02113}.
Interaction partners:
- Proteasome subunit alpha 1
- Proteasome subunit alpha 2
- Proteasome-activating nucleotidase 1
- Proteasome-activating nucleotidase 2
- Glycerol kinase
- Desampylase
- Probable metalloprotease HVO_1016
- Large ribosomal subunit protein eL40
- AAA-type ATPase
Sequence:
MRTPTHDEFSGRLDSLNGDRSNVFGPELGEFSNADRRADELGDKETKTGTTTVGIKTEEGVVLATDMRASMGYMVSSKDVQKVEEIHPTGALTIAGSVSAAQSLISSLRAEVRLYEARRGEDMSMQALSTLVGNFLRSGGFYVVQPILGGVDETGPHIYSIDPAGSILEEEYTVTGSGSQYALGVLEQEFEDGLSIEEAKGVATKAIRSAVERDLASGNGINIAVVTEDGVDIQRHQNFEGLE
Protein: Negative cofactor 2alpha (Q9W2E3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Protein Dr1
- Helicase 89B, isoform B
- TATA-box-binding protein
- TBP-related factor
- Transcription initiation factor IIB
- TATA box-binding protein-like 1
- Dachs, isoform E
- RT01008p
- TBP-related factor 5
- Nuclear factor Y-box B, isoform A
Sequence:
MPSKKKKYNARFPAGRIKKIMQSDEEIGKVAQAVPVIISRTLELFVESLLTKTLRITNARNAKTLSPSHMRQCIVSEKRFDFLKELVRNIPDISVAEEAAYNEDDVLRSSPEEQYPDSDTPYDLSLPSTSMRSQANGTAAYMRSMSLNNGAGSGGGAAATKRQFQSQHSTQETPTTSTTLPAKLARSGSMPAYTPRGRPPNHLKKQSVQLDTAIPAPICNYELNKPIVKIDYSHVQMPTANLCTPDASDSGSGSGAGSGAFNFDIAAPVINIDLTNIVAGGAPGSGVPPASIGLPAATPGDNNNVNQMAGKSSAPIIPKATAASATPTETVFELDEDYDNI
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0B4KHT3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Regulator of G-protein signaling loco
- Discs large 5, isoform A
- Tubulin beta chain
- Endophilin-A
- Cyclin-G-associated kinase
- Myosin heavy chain-like, isoform B
- E3 ubiquitin-protein ligase parkin
- Protein Obscurin
- Serine/threonine-protein kinase Pink1, mitochondrial
- 14-3-3 protein epsilon
Sequence:
MSDSDEARAQGDIGAMEVGAQKLFSNSHPPQKQLVQPLDHPTPTKRQIKTNATHSPNATFLNKCNSCRASWAPTCAVRHKTAWINDHKNVAIDFPQFNAREEVRQIKHGELRTAVISGDERTVRVLLAALGTERQIIVNMAPSGANTLLFLACQSGYESITQRLLDAGADGRSHAVTKYSPLYAAVHSGHLGIARLMLDHFPELIQQPTVERWLPLHAACINGHIKLLELLISYSYPDYLYQTYRDEEGQWEWRLPFDANAHDVTGQTSLYIASILGNKQLVGVLLKWQLHCRRTLGDSASSVSTPITPTRKRISFGIQAIMSKLHISGESEGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGGHLDVVQSLLQHGANPNIVAKPVEDHNDPKCCEEIYGLSNVPIAEACKQRSLAMLDLLLKHGARDDNGTAIGMAITCGDEAILSRLLARRVHPDSDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVPWMVSGVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLTSIPQELFHLVSLRYLNVAQNKITDLPAPIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNKLQQLPFDLWRAPKLRELNVAFNLLRDLPVPPMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFTSIPAALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTNNCLKEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKHKTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANISTVGVDIGTWICEKRKRAPGSHGPVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFIAIPDAEKIGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSKEPMLLQKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDATLRDYYFLDPQWLCDMLAHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNMLCCCLVGEAIWMGDVSGNLHAYSTSTYAHLFSYMLDPNIKSAVISLVYMEKIARVAVGTHNGRVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAACSVVVDGIYELWCGEIAGKINVFPLNENGVSGHQALCHSEEPNLIEDVKVARMCSNESHVFSCLYPGCMVYQWDVISKRIENKLDCSKLLPCSESLQSIAIDEHVNLIKCQISALAAHNSELYIGTTWGCLIVAELHTLRPISVFRPYENEIKSIITLSKDNVPLIATIGRRYRSLISRYVDSAESSTKSSAVSTPTHGAAKSVPPADVDNHIHCLLWRAKHWT
Protein: Phosphotransferase (EC 2.7.1.-) (A2QFF8)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Interaction partners:
Sequence:
MVGIGPKRPPSRKGSMADVPQNLLQQIKDFEDQFTVDRSKLKQIVNHFVKELEKGLSVEGGNIPMNVTWVLGFPDGDEQGTFLALDMGGTNLRVCEITLTQEKGAFDITQSKYRMPEELKTGTAEELWEYIADCLQQFIESHHENEKISKLPLGFTFSYPATQDYIDHGVLQRWTKGFDIDGVEGHDVVPPLEAILQKRGLPIKVAALINDTTGTLIASSYTDSDMKIGCIFGTGVNAAYMENAGSIPKLAHMNLPADMPVAINCEYGAFDNEHIVLPLTKYDHIIDRDSPRPGQQAFEKMTAGLYLGEIFRLALMDLVENRPGLIFNGQDTTKLRKPYILDASFLAAIEEDPYENLEETEELMERELNIKATPAELEMIRRLAELIGTRAARLSACGVAAICTKKKIDSCHVGADGSVFTKYPHFKARGAKALREILDWAPEEQDKVTIMAAEDGSGVGAALIAALTLKRVKAGNLAGIRNMADMKTLL
Protein: Transcription factor 23 (TCF-23) (Class A basic helix-loop-helix protein 24) (bHLHa24) (Q7RTU1)
Organism: Homo sapiens (Human)
Function: Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MSQRKARGPPAMPGVGHSQTQAKARLLPGADRKRSRLSRTRQDPWEERSWSNQRWSRATPGPRGTRAGGLALGRSEASPENAARERSRVRTLRQAFLALQAALPAVPPDTKLSKLDVLVLAASYIAHLTRTLGHELPGPAWPPFLRGLRYLHPLKKWPMRSRLYAGGLGYSDLDSTTASTPSQRTRDAEVGSQVPGEADALLSTTPLSPALGDK
Protein: Outer kinetochore KNL1 complex subunit SPC105 (105 kDa spindle pole component protein) (Spindle pole body component SPC105) (P53148)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3). Involved in kinetochore-microtubule binding and the spindle assembly checkpoint.
Subcellular location: Nucleus {ECO:0000269|PubMed:14565975}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14565975, ECO:0000269|PubMed:22561345, ECO:0000269|PubMed:35042402}.
Interaction partners:
- Spindle assembly checkpoint protein BUB3
- Spindle assembly checkpoint serine/threonine-protein kinase BUB1
- Outer kinetochore KNL1 complex subunit KRE28
- Kinetochore-associated protein DSN1
- Kinetochore protein SPC24
- Kinetochore protein NUF2
- Kinetochore protein NDC80
- Kinetochore protein SPC25
- Kinetochore-associated protein NNF1
- Kinetochore-associated protein MTW1
Sequence:
MNVDERSRIGGREKDAGPGKGILKQNQSSQMTSSFLENPGVRIPTRIITKKEVLDGSNTTSRINTSNLQSMVKRRVSFAPDVTLHSFTFVPEQNNEIKEPRRRKTSTNSPTKISSQEEPLVTSTQIDDARTEEKTAAEEDPDTSGMELTEPIVATPDSNKASQHDPTSMEMTEVFPRSIRQKNPDVEGESIESSQQIDDVEAVREETMELTAIHNVHDYDSISKDTVEGEPIDLTEYESKPYVPNSVSRSTGKSSDYSVERSNDKSDLSKSENKTNSSQPMEITDIFHADPQNPMSLHSDNNINNDGNEMELTQIQTNFDRDNHHIDESPSEKHAFSSNKRRKLDTVSDYAASVTTPVKEAKDTSGEDNDGDLEMMEKMSPITFSDVDNKIGTRSNDVFTIEPGTEDTGMQTATDDEEDGENVDDNGNKIVEKTRLPEIDKEGQSGIALPTQDYTLREFINEVGVGFLDTKLIDDLDKKVNFPLNSFNFVENQRIDNVFSAFYIDIPILEVEAFRCKELWRSINESKDKFKDFEAQIDKSHPPLLLQEYFSSDEKMKQLMRDQLQLVKGYSKLEAAMEWYEWRKKQLNGLELILAENLNTLKREYEKLNEEVEKVNSIRGKIRKLNEAIKEEIRSLKNLPSDSYKPTLMNRIKIEAFKQELMEHSISLSSSNDFTQEMRSLKLAIAKKSNDILTLRSEVASIDKKIEKRKLFTRFDLPKLRDTLKILESLTGVRFLKFSKATLSIAFLQLDDLRVDINLANFKNNPLSSMKVMNDSNNDDMSYHLFTMLLKNVEAEHQDSMLSNLFFAMKKWRPLLKYIKLLKLLFPVKITQTEEEEALLQFKDYDRRNKTAFFYVISLVSFAQGVFSENGQIPMKVHISTQQDYSPSREVLSDRITHKISGVLPSFTKSRIHLEFT
Protein: Uncharacterized GTP-binding protein YGR210C (P42942)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Uncharacterized protein YOR097C
- Probable ATP-dependent kinase TDA10
- Zinc finger chaperone ZPR1
Sequence:
MPRDPLIGIVGKPSSGKSTTLNSLTDAGAAVGAFPFTTIEPNQATGYLQVECACSRFGKEDLCKPNYGWCSKGKRHIPIKLLDVAGLVPGAHSGRGLGNKFLDDLRHADALIHVVDVSGTTDAEGKNTRGYDPLNDIEWLQDEIRLWVEGNLKKRWGSIVRKHTATKSSIVDTLQAQFGGYGSHAPMIQKALDRLKGLPPLEKWDDEWITRVVKSFMMEKFPTVLALNKIDHPDADKNVSKIMLKYPDTKAVLTSAVTEVFLRKLKKQGFILYEEGTEFVDTFEDEPDKLKPLDDKILNRIENIRDLVLYRFGSTGVVQVLQAATDILGLIPVYTVKNIQTFTGGNGTNVFRDCFLVKRGTPVGKVARYIMGGEVTIASIETVGGVRVSEESLVEPGKNDILGFKIAPRSA
Protein: Plant invertase/pectin methylesterase inhibitor superfamily protein (Q9CAL1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Putative F-box/FBD/LRR-repeat protein At5g52460
- Probable pectinesterase 67
- Probable pectinesterase 49
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Bnm1 like protein
- Expressed protein
- Glycoside hydrolase family 28 protein/polygalacturonase family protein
- Putative clathrin assembly protein At1g25240
- Probable pectinesterase 50
- Invertase/pectin methylesterase inhibitor family protein
Sequence:
MSTNLHLATAVILLLLTASQSGVAMAQRVMGGGRDPCSVSDFKVLCRSVVKGQKNVNAATEVSIRELMKRTIKAKEAAKISRKSGGGLKTCYSNYDSALENLQKALKNIKQNDGFSLNINLSASLTDFDTCNDAMGGGTASNVFAKSTSTLHEMADNCLALSTLVKQ
Protein: LIM/homeobox protein ceh-14 (Homeobox protein ceh-14) (P20271)
Organism: Caenorhabditis elegans
Function: Probable transcription factor, modulating expression of helix-loop-helix protein mbr-1 and homeobox protein ceh-63, perhaps acting in concert with ceh-63. Binds to a motif including the sequence 5'-CTAAT-3' in regulatory promoter elements. Confers thermosensory function to neurons. Required for correct AFD-mediated thermotaxis. In concert with homeobox protein ttx-1, perhaps as components in a complex, specifies identity of AFD neurons, acting by synergistically regulating receptor-type guanylyl cyclase gcy-8, gcy-18 and other genes. Involved in postembryonic differentiation of the ALA neuron, and regulation of genes that contribute to behavioral quiescence, a sleep-like behavior mediated by ALA. Regulates its own expression and also that of homeodomain ceh-17, together forming an autoregulatory loop in the ALA neuron. Required for initial pathfinding of the ALA axons, but largely dispensable for axon migration. Involved in regulating postembryonic axon maintenance in the ventral nerve cord, acting in concert with LIM homeobox protein lim-6, via modulation of expression of immunoglobulin domain zig genes in the interneuron PVT. Plays a role in controlling the peptidergic identity of the BDU neurons, regulating expression of flp-10, nlp-1, and nlp-15, thereby modulating the harsh touch response.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10774727}.
Interaction partners:
- LIM/homeobox protein lim-7
- Homeobox protein ttx-1
- LIM interaction domain-containing protein
- Homeobox protein ceh-17
- Transcription factor unc-86
- Homeobox protein unc-30
- Transcription factor unc-3
Sequence:
MLGHNILTLGECDELDNHIVMCSTGLLSPQEDFSNVNAGHPNNEEAICSLCDKKIRDRFVSKVNGRCYHSSCLRCSTCKDELGATCFLREDSMYCRAHFYKKFGTKCSSCNEGIVPDHVVRKASNHVYHVECFQCFICKRSLETGEEFYLIADDARLVCKDDYEQARDKHCNELEGDGSNKRPRTTISAKSLETLKQAYQTSSKPARHVREQLASETGLDMRVVQVWFQNRRAKEKRLKKDAGRRWKSSNRAESDSNSPIESINGQSPNYLYLDHPMDDGNESNYLFHSREQTPDKYYRNETPSTDPPPMHMTTPSVLTTNFSTPLSLSTNVYNLPPPESQLIPHMTPQYI
Protein: Fructose-bisphosphate aldolase (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase) (O51401)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
Interaction partners:
- Glyceraldehyde-3-phosphate dehydrogenase
- Triosephosphate isomerase
- Enolase
- protein-N
- Glucose-6-phosphate isomerase
- Pts system, fructose-specific iiabc component
- L-lactate dehydrogenase
- Phosphoglycerate kinase
- Pyruvate kinase
- 1-phosphofructokinase
Sequence:
MGVLDKIKPGVVYGKELHFLYEICKKEGFAIPSINCIGTNSINAVLEAAKEINSPIMIQFSNSGSAFISGKGLKMEKPQGVSIVGAISGAMHVHLMAEHYGVPVVLHTDHCAKNLLPWVEGLLEYGEKYYSQHKKPLFSSHMLDLSEEPIKENIEISKKFLERMAKIEMFLEIELGITGGEEDGVDNSDRALHELFSTPEDIYYGYSELLKVSPNFQIAAAFGNVHGVYKPGNVKLTPKVLKDGQDYVISKTGVNMAKPVSYVFHGGSGSTIDEINEALSYGVVKMNIDTDTQWAAWEGVLNYYKKNESRLQGQLGDGKDIDIPNKKFYDPRVWLREAEVSMKDRVKIACKNLNNINRN
Protein: BUD13 homolog (F1QH05)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- RNA-binding motif protein, X-linked 2
- Cell division cycle 5-like protein
- Pre-mRNA-processing factor 19
- Activating signal cointegrator 1 complex subunit 3
- Microfibril-associated protein 1.
- Pre-mRNA-splicing factor CWC22 homolog
- Smad nuclear-interacting protein
- Cell division cycle 40 homolog
- E3 ubiquitin-protein ligase RNF113A
- MCG1346-like protein
Sequence:
MAASTGISKGAALSKADYLKRYLSNDEADKKSKEKKVKKKRPKPSGKGMKIVDDDIDWRQLAAREEENKEDDEEEDEAPVVAEVIDERPDEIKQFEAFKTSKWRVMGATGEDLQENEESTFNRSSDTDKGHRLRHDSPEGSSVRKVRHDSPDLSPKRARHDSPDLSPPKKGRHDSPDLSPQRPKTENKNRRHDSSSPSPPRLSHISTPSRTQRHHDKGSTHRKKMKGSSSGDLSPPRRRDRTGKGSDSDQSPPRRRPHGRRGLDSDLSPPRKRGHGGGGSDSDLSPPRKRVQGGQGSDSDLSPPRRTRSPDGQAAPRMLSGGAAGLVSVDILRKEQEEIRRREKRNQPLEEASRNAETIFRDKSGRKRNLESEKAELSQKASEKAEKDEKYAQWGKGLAQGEMQEQNVIDAIREAEKPLARHIDDEDLDRMLREQEREGDPMAAMLRKKKDKTAKLKGVKEKPCYKGPPPPPNRFNIMPGYRWDGVDRSNGFEQKRYSRMADNKAVQEMAYKWSVEDM
Protein: Ependymin-related protein 1 (P86734)
Organism: Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone)
Subcellular location: Secreted {ECO:0000269|PubMed:21050442}.
Interaction partners:
Sequence:
MILQAALFLAGLTVVSGSICCPPKQFNSYQYVTFVNSTTTIRALYYIVYDGDNQRYLITGDRNNKQLVGTTKVIYDYKKRIAYSIDAKARTCSKFPVQGQFEDQENVCVPGGAEILGPLFYGYNQSRLNSQSYAYNTTSLDGSHHNVVTTVSEDDCVPIVICTITTGGPGGNSLYTVGYNDFYPGIKDITVFDIPPYCNA
Protein: Aquaporin (Q0IIQ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Aqp8a protein
- Aquaporin 7
- Aquaporin-3
- Aquaporin-4
- Aquaporin 10a
- Aquaporin-10b
- Aquaporin 9b
- Urea transporter
- Aquaporin-0a
Sequence:
MSGLNSSLGFFLAVVGLSVSGRLLLRRWTVLLELVSAFALCACRLEVDTIAEVGQWAGALGPDVAVTMLFLSIAVHTAVMQDVSGNPAVTLLRLLQRDVSVVVAVLSIAAQLIGAFLALEVAGRFWAMELSDMHMIKNLMMSECSTSLRVSTALGVSTEALAALLLLLLHLVLKNRSQMLKVPALSVALTLIAYTANNYTSGYVNPALAYAVTFTCPGHSFLVYSLVYWLGPLIGVFLAVFLYLGNIPLLFSKNLLYSKKNRFRLPKGKTNDEKSS
Protein: Histone H3.3 type 2 (H2L2K8)
Organism: Caenorhabditis elegans
Interaction partners:
- Histone H3.3-like type 2
- Histone H3.3-like type 1
- Histone 24
- Protein unc-119
- Histone H3.3 type 1
- Putative histone H3.3-like type 3
- Hpc2-related domain-containing protein
- Pre-mRNA-splicing factor CWC22 homolog
Sequence:
MREQQWLVPSKPLVNPPEERLQESSWPPRPPANRLQPPEESRSHIVTVQELSLSVRFVVTRSRLSFSSASFLSNVSFVRLPRTSRLISASSRLPSELSRRHLKHTSSDSSRTPTCAPSTPSASPSCQRTCNSPDASAENVLKLHHQFSKHF
Protein: Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Q9VLM8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03133}.
Interaction partners:
- Tyrosine--tRNA ligase
- Bifunctional glutamate/proline--tRNA ligase
- Glycine--tRNA ligase
- Valine--tRNA ligase
- histidine--tRNA ligase
- Asparagine--tRNA ligase, cytoplasmic
- Methionine--tRNA ligase, cytoplasmic
- Cysteine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase
- Probable glutamine--tRNA ligase
Sequence:
MKLLTAKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRVANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLYVTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRSVPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFVPLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILRRAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLNRTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQGKGASKIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFVNEITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVEGTLKVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDSEAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRLKATIDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALRAAVSVTVVERAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKLS
Protein: Kinesin light chain 2 (E9PM83)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MAMMVFPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGSQERCILLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDTLDDLFPNE
Protein: Urotensin-2 (Urotensin II) (U-II) (UII) (O95399)
Organism: Homo sapiens (Human)
Function: Highly potent vasoconstrictor.
Subcellular location: Secreted.
Interaction partners:
- Urotensin-2 receptor
- Urotensin-2B
- Endothelin-1
- Urocortin
- Somatostatin
- Angiotensinogen
- Somatostatin receptor type 4
Sequence:
MYKLASCCLLFIGFLNPLLSLPLLDSREISFQLSAPHEDARLTPEELERASLLQILPEMLGAERGDILRKADSSTNIFNPRGNLRKFQDFSGQDPNILLSHLLARIWKPYKKRETPDCFWKYCV
Protein: Ankyrin repeat domain 7 (C9JIJ7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MNKLFSFWKRKNETRSQGYNLREKDLKKLHRAASVGDLKKLKEYLQIKKYDVNMQDKKYRTPLHLACANGHTDVVLFLIEQQCKINVRDSENKSPLIKAVQCQNEDCATILLNFGADPDLRDIRYNTVLHYAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAVINNNPKMVKFLLEKGADVNASDNYQRTALILAVSGEPPCLVKLLLQQGVELCYEGIVDSQLRNMFISMVLLHTHNSLRAMERRNMLNRHLILGTTCD
Protein: Ras-like protein rasB (EC 3.6.5.2) (P32252)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Interaction partners:
- Ras guanine nucleotide exchange factor Q
- Probable serine/threonine-protein kinase roco5
- Neurofibromin-A
- Rac guanine nucleotide exchange factor B
- Uncharacterized protein
- Ras guanine nucleotide exchange factor C
Sequence:
MSVSNEYKLVVMGGGGVGKSALTIQFIQNHFIEEYDPTIEDSYRRQCQVDEDTCLLDILDTAGQDDYSAMRDQYMRTGQGFLCVYDVTSRTSFEEINVVREQIIRVKDNDKVPIVLVGNKCDLENLREVTEGEGSELAKSFSVPFLETSAKKRLNVDECFFEVVREIKKSLKEPGRSKKDKKGGILKKFKGGDCLIL
Protein: Transcription factor SKN7 (Peroxide sensitivity protein 9) (P38889)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.
Subcellular location: Nucleus {ECO:0000269|PubMed:10888672, ECO:0000269|PubMed:14665464}.
Interaction partners:
- AP-1-like transcription factor YAP1
- Phosphorelay intermediate protein YPD1
- Thioredoxin-1
- Thioredoxin-2
- Thioredoxin reductase 1
- Osmolarity two-component system protein SSK1
- Regulatory protein SWI4
- Mitogen-activated protein kinase HOG1
- Zinc finger protein MSN2
- CRE-binding bZIP protein SKO1
Sequence:
MSFSTINSNVNKTTGDSNNNTTENSSTADLLGMDLLQSGPRLMNTMQPNNSSDMLHINNKTNNVQQPAGNTNISSANAGAKAPANEFVRKLFRILENNEYPDIVTWTENGKSFVVLDTGKFTTHILPNHFKHSNFASFVRQLNKYDFHKVKRSPEERQRCKYGEQSWEFQHPEFRVHYGKGLDNIKRKIPAQRKVLLDESQKALLHFNSEGTNPNNPSGSLLNESTTELLLSNTVSKDAFGNLRRRVDKLQKELDMSKMESYATKVELQKLNSKYNTVIESLITFKTINENLLNNFNTLCSTLANNGIEVPIFGDNGNRNPTGNTNPATTTAIQSNNNTNNASPATSTVSLQLPNLPDQNSLTPNAQNNTVTLRKGFHVLLVEDDAVSIQLCSKFLRKYGCTVQVVSDGLSAISTLEKYRYDLVLMDIVMPNLDGATATSIVRSFDNETPIIAMTGNIMNQDLITYLQHGMNDILAKPFTRDDLHSILIRYLKDRIPLCEQQLPPRNSSPQTHSNTNTANSNPNTINEQSLAMLPQDNPSTTTPVTPGASISSAQHVQQGQQEQQHQIFHAQQQQQHHNAIANARSDVAIPNLEHEINTVPHSSMGSTPQLPQSTLQENQLS
Protein: Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) (Q63450)
Organism: Rattus norvegicus (Rat)
Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-516', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation (By similarity). Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-275' and 'Ser-294'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Interaction partners:
- Calmodulin-like protein 3
- Calmodulin-1
- Calmodulin-like protein 4
- Nitric oxide synthase 3
- Cyclic AMP-responsive element-binding protein 1
- Protein phosphatase 1F
- Uncharacterized protein.
- Neuronal migration protein doublecortin
- Rho guanine nucleotide exchange factor 7
Sequence:
MPGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPTAGGPAAGCCCRDCCVEPGSELPPAPPPSSRAMD