wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] (O75460)
Organism: Homo sapiens (Human)
Function: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity. The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA. The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes. Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
- Mitogen-activated protein kinase kinase kinase 5
- TNF receptor-associated factor 2
- X-box-binding protein 1
- Cyclic AMP-dependent transcription factor ATF-6 alpha
- Presenilin-1
- Presenilin-2
- Small ribosomal subunit protein RACK1
- Tumor necrosis factor
- E3 ubiquitin-protein ligase synoviolin
Sequence:
MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL
Protein: Ribonuclease X25 (EC 4.6.1.19) (Q9VSC3)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- LD22655p
Sequence:
MQSQRFLFVAILACFLVTIKSTPLSDISYSDESTSVNEKTQKRPDDDSEFDGFPFREDDDSLQDSSREMSVQDHNWDVLIFTQQWPVTTCYHWREENPDQECSLPQKKEFWTIHGIWPTKLHQMGPNFCNNSANFDPSKLNPIEDRLETFWPDLKGMDSTEWLWKHEWQKHGTCAMLVEELDNELKYFEQGLTWREEYIMSRILDASDIHPDSNNTVAAINNAIVKALGKNPSIHCLYDGKHGISYLSEIRICFSKSLELIDCDGIKQGDAVPVGVPGGTIITNCHIGSLVHYPSLVPPLQRKSHWKLPLVNVYKLLQFLMWFTL
Protein: Thioredoxin domain-containing protein (P91194)
Organism: Caenorhabditis elegans
Interaction partners:
- C2 domain-containing protein
- PH domain-containing protein
- Uncharacterized protein F15G9.5
- cAMP-dependent protein kinase, catalytic subunit-like
Sequence:
MKTSSFLTLITVSVIFLVFLSTHVDAKKKDKNLKVTVADDVAPPAPAKKSKKSAVKEAPAPPPKALSSKHKDDDNSIDDVDEDRIDEILRDASKNLVIFLYDGKVPCPTCTEALSEVEEIDDDIEATGYVQVVKTNDRSVARELGINVFPSLVYYRRKNPILYDGDFKDSETLLRWLRAHEEVATWDLTDDTFESRTDSHSPDEGSIDWFVMFYDADEGNSNAFVPLWETVAHKLRGLVNVGKIEISVNDDVTERFHIEERDCPVFLLFHRGKMYRYKESAKDARSLTNFALHKYKEQRGHRVPEPPTAIEQVYEFAKEKIMDIMDDNQTLSVLGVGGLIVIVAVTLIIKAYRIRAENKNKVA
Protein: Probable protein phosphatase 2C 52 (AtPP2C52) (EC 3.1.3.16) (Q8GY60)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- F-box protein At4g02733
- Defensin-like protein 8
- Putative defensin-like protein 3
- F-box protein At4g00893
- Guanine nucleotide-binding protein subunit beta
- Allantoinase
- Probable protein phosphatase 2C 62
- Probable protein phosphatase 2C 80
- Putative F-box protein At4g05475
- Putative protein phosphatase 2C 53
Sequence:
MGGCVSTSSKSTCSSWSNGEKPVRRPYLGIGCCVSKRAKRTFSDHIVSLQNLTSIPNRITSSSKSRSSCIFTQQGRKGINQDAMIVWEDFMSEDVTFCGVFDGHGPYGHLVARKVRDTLPVKLQFFFQTLQSKQNCSKGTRFRRNSSKSAVQEAVKEGSDEDKLKGLWGEAFLKSFKAMDKELRSHPNLDCFCSGSTGVTILKQGSNLFMGNIGDSRAILGSKDSNDSMVATQLTVDLKPDLPREAERIKRCKGRVFAMEDEPEVPRVWLPYDDAPGLAMARAFGDFCLKEYGVISVPEFTHRVLTDRDQFIVLASDGVWDVLSNEEVVDIVASATSRASAARTLVNSAAREWKLKYPTSKMDDCAVVCLFLDGKMDSESDYDEQGFSSATNAVESDDGQRSEPCLQRNFTVRSSSDQENETYGNVNTETDAEDEKTVGDQNWLGLQGVTRVNSLVQLPRFSEEKSKT
Protein: APOBEC1 complementation factor (APOBEC1-stimulating protein) (Q9NQ94)
Organism: Homo sapiens (Human)
Function: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
Subcellular location: Nucleus {ECO:0000269|PubMed:12881431, ECO:0000269|PubMed:24916387}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12881431}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.
Interaction partners:
- C->U-editing enzyme APOBEC-1
- Apolipoprotein B-100
- DNA dC->dU-editing enzyme APOBEC-3F
- DNA dC->dU-editing enzyme APOBEC-3G
- Heterogeneous nuclear ribonucleoprotein Q
- Putative C->U-editing enzyme APOBEC-4
- C->U-editing enzyme APOBEC-2
- DNA dC->dU-editing enzyme APOBEC-3H
- DNA dC->dU-editing enzyme APOBEC-3A
- Cytidine deaminase
Sequence:
MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKVEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRKLLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGTMLQGEYTYSLGQVYDPTTTYLGAPVFYAPQTYAAIPSLHFPATKGHLSNRAIIRAPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDILPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAFVDEAKTYAAEYTLQTLGIPTDGGDGTMATAAAAATAFPGYAVPNATAPVSAAQLKQAVTLGQDLAAYTTYEVYPTFAVTARGDGYGTF
Protein: Protein IQ-DOMAIN 1 (AtIQD1) (Q9SF32)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in cooperative interactions with calmodulins or calmodulin-like proteins. Modulates expression of glucosinolate pathway genes. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level. Recruits KLCR1 and calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:15960618, ECO:0000269|PubMed:23204523, ECO:0000269|PubMed:28115582}. Nucleus, nucleolus {ECO:0000269|PubMed:28115582}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23204523, ECO:0000269|PubMed:28115582}. Note=Recruits KLCR1 and calmodulin (CaM2) to microtubules, nucleus and nucleolus. {ECO:0000269|PubMed:23204523, ECO:0000269|PubMed:28115582}.
Interaction partners:
- Protein KINESIN LIGHT CHAIN-RELATED 1
- Dof zinc finger protein DOF1.1
- Calmodulin-1
- Calmodulin-2
- Calmodulin-7
- Calcium-binding protein CP1
- Calmodulin-6
- Calmodulin-like protein 10
- Transcription factor MYB51
- Transcription factor MYB34
Sequence:
MVKKAKWLKNVKKAFSPDSKKLKHESVECQDSVISYPVLIATSRSSSPQFEVRVDEVNYEQKKNLYPPSSDSVTATVAHVLVDSPPSSPESVHQAIVVNRFAGKSKEEAAAILIQSTFRGHLARRESQVMRGQERLKLLMEGSVVQRQAAITLKCMQTLSRVQSQIRSRRIRMSEENQARHKQLLQKHAKELGGLKNGGNWNYSNQSKEQVEAGMLHKYEATMRRERALAYAFTHQQNLKSFSKTANPMFMDPSNPTWGWSWLERWMAGRPWESSEKEQNTTNNDNSSVKNSTNRNSQGGETAKSSNRNKLNSSTKPNTPSASSTATRNPRKKRPIPSSIKSKSSDDEAKSSERNRRPSIARPSVSDDETLSSSTARRSSNLIPTTKSARGKPKSQTSSRVAVTTSTTEESSILPEKAPAKKRLSTSASPAPKPRRSSAPPKVEKGVLKAERTP
Protein: Dendrin (O94850)
Organism: Homo sapiens (Human)
Function: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).
Subcellular location: Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Perikaryon {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. {ECO:0000250}.
Interaction partners:
- Protein KIBRA
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
- Nephrin
- Synaptopodin
- CD2-associated protein
Sequence:
MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAPSRQPMDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPPGRPRPEPRNAPRVAQLAGLPAPLRPERLAPVGRAPRPSAQPQSDPGSAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPGNSQVPTSSAPAATPARTDGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQAKATGSAGTEIAPAGSATAAPCAPHPAPRSRHHLKGSREGKEGEQIWFPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESLGLGEGAGPETLEGWKATRRAHTLPRSSQGLSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKPGKEEGEGATVFPSPCQKRLSSSRLLHQPGGGRGGEAEGGRPGDSTLEERTFRILGLPAPEVNLRDAPTQPGSPEHQALGPAASGAQGRAEGSEVAVVQRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEAEELSVHSGSSDGSDTEAPGASWRNERTLPEVGNSSPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQGNRKRQ
Protein: Myosin-1 (Type II myosin) (P08964)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for cell division.
Interaction partners:
- Myosin light chain 1
- Ras GTPase-activating-like protein IQG1
- Actin
- Myosin light chain 2
- Cytokinesis protein 2
- Cytokinesis protein 3
- Ingression protein 1
- Bud neck protein 5
- Centractin
- SWI5-dependent HO expression protein 4
Sequence:
MTGGQSCSSNMIVWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFDKVENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVENFKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVSDRAEQASFKNDVSAICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNYIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQNSSKFKRSRLKNGFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVKKSARTSTFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLVKEDPWFNLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAHQKIQGLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVINSKEEEIKSFNDKLSSSEEDLDIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQLKNKESELLKMKEKIDNHKKELATFSKQRDDAVSEHGKITAELKETRIQLTEYKSNYQKIKEEYSNFQRETKEQEQKKRNSLVESLNDSKIKELEARLSQEISLNQYLNKRISGNSVETNISSTRRSTSYSDDPLDKEDIIKKYYDLQLAFTEITRNLENEIEEKKNLISRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKESDINKLMLEVDYLKRQLDIETRAHYDAENAISALHSKFRKIQGESSLSSSDIYKLKFEASEERVKSLEDKLKTMPLRDRTNLPVGDIIKNRDSISKYEEEIRYYKLENYKLQEILNESNGKLSQLTLDLRQSKSKEALLSEQLDRLQKDLESTERQKELLSSTIKQQKQQFENCMDDLQGNELRLREHIHALKQAEEDVKNMASIIEKLKTQNKQKEKLIWEREMERNDSDMQLQETLLELKRVQDVKKILSDDLAHLKERLSAVEDRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETSTNDSEAKISDLLKQLDHYTKVVEMLNNEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLNQKTDALQISNAALSSSTQKNKEITEKIKYLEETLQLQMEQNSRNGELVKTLQASCNGYKDKFDDEKQKNIDLYEENQTLQKLNTDLQLQLKNLHERLSDTTEKNAWLSKIHELENMVSLETDLKYEEMKKNKSLERAVEELQTKNSQQTDVIELANKNRSEFEEATLKYEAQISDLEKYISQQELEMKKSIRDNSSYRDKVQEMAQEIEFWKSRYESTMIGSKNIDSNNAQSKIFS
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q38CA2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTSRAPWDACTTQSTPQMGNGAQSHHLSGWRRFPRGQQIGSGSFGSVFLSHDTLPGSEWYGQLVAVKVIQLKAISDDEVAHAMNEVAILKNLRHTNVLQYVDSFVDDEQQLCLVTEYMAGGDLSLLLRGSGVCGSRSGSNEKRRSVCSGGGDASMRCGSRSSGRRNAWKTTSRGDKSPSEEHQQWIESFRIVDLVRQCLDGLAHLHECGIIHRDVKPANVYLTESDVVKIGDFGVSKVVSPTDPKLVTFIGTPFYLCPELCLGEPYSFGADIWALGVLTYELYCMKLPFAADNVLAQIHVVTEGQYDREALHCEHTFTPKQLHLLESQYGDAFTRQEKTLHQLVVVLVERMLVMDPMERPSAAQLLREFFIFNPSRCPTPAATPPPSRLSAAEVCDLWATNGIATQTNRVNRLCCRIGSGGEMDDIFPLAAAIPTTSSPLASRVAGSYEELVSSLMPVERRYDVLHISERSGYSTPASSRPVTSQGAASDIADPGGTDAFDTFTQEMINAKISRIPWLRHAEAFSRLSLCEGYDGEVVRVDWKDGENFTLVSSPHKHRNSTPGLRRSRVSDGLSVMGQLALFAEPLSGVDAGSKSMSELLEARLLEVSQSPMASSLTEKSRTTECVITLEANRTAKRQEMEGEADKECENSGGPHMLVGRCRGYSTQTLEAILRKKIYFSYLRRQRKLRAVREAQKAREEESKRLRAELNELYARSYTEKCRHMFAQGGSSRADQFPYPPDELQMTRAPCQLAQVTGLRFESGNFSHDSTAVTKTIDKLAELSCCKPHRPESTVLQPSKLAAEIVRMAADAAAVAARRAEFAAHPPLRLDFRNSDGRSMSCSYSSSVGDPSRGMNTAIYTIPISLYIVRSDIDVSCSRTSIVSDVCDGLLALPMSVALKPIRRRTRLRGIVWRVKEALKANGLDHVLLFPLDIDDDEQVGAEELSLRYVDSAGDAVVVSEPSDWRYTLRDWRKNMNQSWLQLWMAMS
Protein: RecQ-mediated genome instability protein 1 (Q9D4G9)
Organism: Mus musculus (Mouse)
Function: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Note=Forms foci in response to DNA damage. {ECO:0000250}.
Interaction partners:
- DNA topoisomerase 3-alpha
- Fanconi anemia group M protein homolog
- RecQ-mediated genome instability protein 2
- RecQ-like DNA helicase BLM
- Replication protein A 70 kDa DNA-binding subunit
- Replication protein A 14 kDa subunit
- DNA topoisomerase 3-beta-1
- Replication protein A 32 kDa subunit
- Fanconi anemia group F protein
- Structure-specific endonuclease subunit MUS81
Sequence:
MSVASAVLRVETWLLATWHVKVPPMWLEACVNWIQEENNNATLSQAQINKQVLEQWLLTDLRDLEHPLLPDDILELPKGELNGFYALQINSLVDVSQPAYSQIQKLRGKNTTNDLVSAETQSTPKPWEVRPSRMLMLQLTDGVTHIQGMEYQSIPALHSGLPPGTKILVRGCILFRLGVLLLKPENVKVLGGEVDGLSEENAQEKVLARLIGELDPTVPVIPNNSIHNVPKVSGGLDAVLGPSDEELLASLDESEESAANNDVAMERSCFSTGTSSNTTPTNPSGFEPGCNISSRPKEKPPNQPTHFTDGEFDDFSLEEALLLEETVQKEQMETKASQPLTLKENTGKCMEIFSHKPSSLNHTALIHKQGNSNFDEKTSEQMIHEDKFFDCASTRNHHKRFSAHDFTNDSKISEVDDAAQQTLSSSNVHCLRNKILNRKLDLSEKSSQISKENGHPFQACSSRSFENNTYLSIGMDLHSPPFIYLSVLMARKPKEVTTVTVKAFIVTLTGNLSSSGGFWGVTAKVSDGTAYLDVDFIDEILTSMIGYSVPEMKQLRKDPLKYKTFLEGLQKCQRDLIDLCCLMTISYDPSSCKGVVLELQDVGMEHVENLKKRLNK
Protein: POU domain protein (Q6XZH1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Interaction partners:
- Visual system homeobox 2
- Transcription factor atoh7
- Insulin gene enhancer protein isl-1
- Paired box protein Pax-6
- Synuclein, gamma b
- Visual system homeobox 1
- BarH-class homeodomain transcription factor
- Homeobox protein OTX2
- Cellular tumor antigen p53
- Forkhead box protein N4
Sequence:
MMMMSLNSKQAFAMPHTSLAEPKYSSLHSSSSSSTLTSNAPSSSCSSSRHSSTISSSGGGSSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQTKSHHHPPHHSPFKPDATYHTMNTLPCTSSSSSSSVPISHPSALASHHHHHHHHHHQPHQALEGDLLDHITPGLALAGAMAGPDGSVVSTPAHPAHMAGMNHMHQAAINMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALASLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLNKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSACV
Protein: Forkhead box L1 (Forkhead box protein L1) (Q7SY22)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00089}.
Interaction partners:
Sequence:
MSLYHSPVPQSGVAASALGLSGSSLIYVYGGEVGGIIPALGFASGRQEPPQKPPYSYIALIAMAIKNAPDKRATLSGIYQFIMDRFPYYHDNKQGWQNSIRHNLSLNDCFIKVPREKGRPGKGSYWTLDTKCLDMFENGNYRRRKRKCRTQDTGDTKVGHKRTRVTSFKLHQGAQSEKVSPLKQNPGRDIKEKSNDTQPQNEEENVASESAKDWCLASSTTIVSLPRCTTPERSSTVSTVAVNTHTPLSSASETRVPVKSDTGRAQSGDAKSKESNPRKTTDKAKEFSIDSILSKKENQFQRRCAAAGGASVDSRGYALASSLIAHAHPQLYPRGFPLCSYLSLTCPDKILSLTEKTDEKLFF
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q99PS2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
- Cryptochrome-1
- Period circadian protein homolog 2
- Basic helix-loop-helix ARNT-like protein 1
- Period circadian protein homolog 1
- Period circadian protein homolog 3
- Neuronal PAS domain protein 2
- Cryptochrome-2
- Glycogen synthase kinase-3 beta
- Protein LTV1 homolog
- Casein kinase I isoform delta
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQQAGNTSPRAISRADRERKVSMRLHRGAPANVSSSDLTGRQEVSRIAASQAANTPLVTLGHTPATCSHHRPPRAGPPSEVPEELASGSGLASQRQVLGDFIEPWMTRHQPSGDDSGQLCIGLSHNPLPEHPGHHTHFSPLCRDPEGAVRW
Protein: PML-RARA-regulated adapter molecule 1 (PRAM-1) (Q6BCL1)
Organism: Mus musculus (Mouse)
Function: May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
Interaction partners:
- Src kinase-associated phosphoprotein 2
Sequence:
MGSNQDFRNLQAKFQTSQPELGELFRKTPKPELNKVLKKFPQTELSEQPKKSSQSELSAVSLKPLQLQFADLPRKPPQPGVLKKSPQPEFPHLANKPVQAEFPRKPLHPEFTGLKKPSQAEFTDLKKPPQPQFASLPKKPPKPEFGELSKRPPQLETPQEPSAPPAQKLLKPEPNNPARPLGELKPKMFWHLEANEAPKRPLPSESSTFPKKPLQPEAVVGFSRKSQPQSESIEVSQTSPSKCGSRELDSHSPQPDISTFPKNNENFRKPSYPQATGCPKSPKQPMFYEFPQTPPRKPESCNPQSHSPLPDFNAFPKKHPQLQPSDLTRASSEPEVCKVPKKTQKPDPNVLSQKPSQPELGHLPRTSSDPEFNSLPRKFLQPQHGKFFQPEFPKGLPRKPKLPGSVSECSLPSASAGSSPQCPLSPGLIVPGIPRWRSEDFQVQRPPRRRPLPSASSLGHPPAKPALPPGPINIQSFRRAAATAAAVLKTGSSTGTHFQAQQPQHIAQNPDEIYELYDAVEATDDSSISPRGRDEMLSTQQATRWPQQEPELRKKATQPQQLPATDPKLLKQIRKAEKAEREFRKKFKFEGEIVIHTKMMIDPNAKTRRGGGKHLGIRRGEILEVIEFTSKDEMLCRDPKGKYGYVPRTALLPLETEVYDDVSFGDPLDMQPFPR
Protein: Integrin alpha-V (G3HHR9)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Interaction partners:
- Integrin beta
- Integrin beta
- Integrin beta
- Integrin beta
- Integrin beta
- Osteopontin
- Polymerase delta-interacting protein 2
- Integrin-binding sialoprotein
- Focal adhesion kinase 1
- B9 domain-containing protein 2
Sequence:
MFLLVGAPKANTTQPGIVEGGQVLKCDCSSSRRCQPIEFDSTGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTELKQEREPVGTCFLQDGTKTVEYAPCRSSQLISDQVAEIISKYDPNVYSIKYNNQLATRAAQAIFDDSYLGYSVAVGDFNGDGIEDFVSGVPRAARTLGMVYIYDGKNMSSLHNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRALGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDQKGLVYIFNGRSTGLNSVPSQILEGQWAAQSMPPSFGYSMKGATDVDRNGYPDLVVGAFGVDRAILYRARPVVTVNAGLEVYPSILNQDNKICPLPGTSLKVSCFNVRFCLKADGKGTLPKRLNFQVELLLDKLKQKGAIRRALFLHNRSPGHSKNMTVFRGGQMQCEELVAYLRDESEFRDKLTPITIFMEYRLDHRTAADVTGLQPILNQFTPANVSRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLTVKAQNQGEGAYEAELIVSIPPQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLKIQSSNSFDNVSPVVSYKVDLAVLAAVEIRGVSSPDHIFLPIPNWEYKENPETEEDVGPVVQHIYELRNNGPSSFSKAILNLQWPYKYNNNTLLYILHYDIDGPMNCTADTEINPLRIKIPEKNDTSTGQGDRHHLITKRDLTLSEGDVHTLGCGVAKCLQIICQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNIIEFPYKNLPIEDLFNSTLVTTNITWGIQPAPMPVPVWVIIMAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET
Protein: H-2 class I histocompatibility antigen, Q9 alpha chain (P14431)
Organism: Mus musculus (Mouse)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
Sequence:
MALTMLLLLVAAALTLIETRAGQHSLQYFHTAVSRPGLGEPWFISVGYVDDTQFVRFDSDAENPRMEPRARWMEQEGPEYWERETQIAKGHEQSFRGSLRTAQSYYNQSKGGSHTLQWMYGCDMGSDGRLLRGYLQFAYEGRDYIALNEDLKTWTAVDMAAQITRRKWEQAGIAEKDQAYLEGTCMQSLRRYLELGKETL
Protein: Mesencephalic astrocyte-derived neurotrophic factor homolog (ARMET-like protein) (MANF/CDNF-like protein) (Q9N3B0)
Organism: Caenorhabditis elegans
Function: Inhibits endoplasmic reticulum (ER) stress response (By similarity). Retained in the ER under normal conditions and is up-regulated and secreted by the ER in response to ER stress and hypoxia (By similarity). Following secretion by the ER, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress under ER stress conditions (By similarity). Has a neuroprotective role, ensuring survival of dopaminergic neurons during normal growth.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P55145}. Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P55145}. Note=Retained in the endoplasmic reticulum (ER) under normal conditions. Up-regulated and secreted by the ER in response to ER stress. {ECO:0000250|UniProtKB:P55145}.
Interaction partners:
- Heat shock 70 kDa protein C
- Endoplasmic reticulum chaperone BiP homolog
- BZIP domain-containing protein.
- DnaJ homolog dnj-20
- Ubiquitin-conjugating enzyme E2 13
- Saposin B-type domain-containing protein
- Endoplasmic reticulum transmembrane protein
Sequence:
MSRLVLLISLVIVVASAAAPQCEVCKKVLDDVMAKVPAGDKSKPDAIGKVIREHCETTRNKENKFCFYIGALPESATSIMNEVTKPLSWSMPTEKVCLEKLKGKDAQICELKYDKPLDWKTIDLKKMRVKELKNILGEWGEVCKGCTEKAELIKRIEELKPKYVKEEL
Protein: PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) (Q3TJD7)
Organism: Mus musculus (Mouse)
Function: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity). {ECO:0000250}.
Interaction partners:
- T-box transcription factor TBX4
Sequence:
MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLNIDGENAGSLTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKALTPPADPPRYTFAPSASLNKTARPFGAPPPTDSTLRQNGQLLRQPVPDASKQRLMEDTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEFMKKSSQVPRTEAPAPASTIPQESWPGPTTPSPTSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQNRTSIVQAAAGGGTGGGSNNGKTPVCHQCHKIIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPSCYDVRYAPNCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGAPYCERDYEKMFGTKCRGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDKPLCKSHAFSHV