wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein acetyltransferase YopJ (EC 2.3.1.-) (Virulence factor YopJ) (P0DUD0)
Organism: Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Function: Serine/threonine-protein acetyltransferase translocated into infected cells, which inhibits the host immune response and induces cell death by mediating acetylation of target proteins. Inhibits the MAPK and NF-kappa-B signaling pathways by acetylating protein-kinases such as MAP2K1, MAP2K6, MAP3K7/TAK1 and I-kappa-B kinase (CHUK/IKKA and IKBKB) on serine and threonine residues critical for their activation by phosphorylation, thereby preventing protein-kinase activation (By similarity). Promotes pyroptosis, a programmed cell death, in host cells by mediating acetylation of MAP3K7/TAK1: MAP3K7/TAK1 inactivation triggers activation of caspase-8 (CASP8), followed by CASP8-dependent cleavage of gasdermin-D (GSDMD) and induction of pyroptosis (By similarity). Also able to induce intestinal barrier dysfunction by acetylating and inhibiting host protein-kinases RIPK2/RICK and MAP3K7/TAK1, thereby promoting cell death.
Subcellular location: Secreted {ECO:0000269|PubMed:8045884, ECO:0000269|PubMed:9535085}. Note=Secreted via type III secretion system (T3SS). {ECO:0000269|PubMed:9535085}.
Interaction partners:
Sequence:
MIGPISQINISGGLSEKETSSLISNEELKNIITQLETDISDGSWFHKNYSRMDVEVMPALVIQANNKYPEMNLNLVTSPLDLSIEIKNVIENGVRSSRFIINMGEGGIHFSVIDYKHINGKTSLILFEPANFNSMGPAMLAIRTKTAIERYQLPDCHFSMVEMDIQRSSSECGIFSFALAKKLYIERDSLLKIHEDNIKGILSDGENPLPHDKLDPYLPVTFYKHTQGKKRLNEYLNTNPQGVGTVVNKKNETIVNRFDNNKSIVDGKELSVSVHKKRIAEYKTLLKV
Protein: Uncharacterized protein, isoform B (EC 3.4.14.1, EC 3.4.14.2, EC 3.4.14.4, EC 3.4.14.5) (Uncharacterized protein, isoform C) (Q9VMM2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MPINPLLITAFGLFITVCPRPSTAAAVIGRVDGAEGNKTAWELTEALYGTSGLRSFNGTWITGTYYTATDRSIHKFNAATKTDVIFQNSSFLNNYVGATFSLSPDNTKILIRHNLTEKFRHSYIAQYDVFDIETNTTVQIHKGEKLQYCGWSPLRDRLAYVYLNNVFIHFSESLEISITDDGVDGVVYNGVPDWVYEEEVLSSGSAIWWSSDGSRLAVGFFNDTEVETFTYFLYGDGATTFYQYPHEEQLKYPKSGSKNPVVSLRVYDVSDNDPTMHTIVAPVDIVGDDHILQSVVWSNSTHLLITWMNRRQNLTSIQSCSYEGDCVEVKRLEEPQGWVDISTPKCLSTGKSCIFGYFIDNWHQVWNLDLETGLNSWQSRGNFTVLSVYGYDEARDKLYYQATLPGDPSVYHVFSNDECLSCGQIDADGAACRSASGTFSKSFSYYTLSCTGPNPSYTRIFEASTKTLQVDWEPNTAYRKQIEEKLRPSYRFMNVTLADGSIGYAKLALPPNFVETKKYPLIVVVYQGPNSVRVTNGFTLGYEAFVTTSRDTIYAYIDGRGTGNKGKDLLFSVNNDLGDHEVEDQLFVTRWMQQNLAFVDAERCGIWGWSYGGYMTAKTIEKDDDRVFQCGVSVAPVTSWLYYDTIYTERYMGLPTDDDNLKKYNESSVFGNLENFKSHDFLLIHGSGDDNVHYQHSLLLAKLLQRQDIQFEEQTYTDENHGIGNALPHLYHTIDAFWTNCLNLDVYEDSA
Protein: Large ribosomal subunit protein bL12 (50S ribosomal protein L7/L12) (P0A471)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
Interaction partners:
Sequence:
MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAADAADAGAAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPALVKEGVATAEAEEIKAKLEEAGASVTLK
Protein: Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)] (P03375)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)
Function: Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41.
Subcellular location: [Surface protein gp120]: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Host endosome membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. {ECO:0000255|HAMAP-Rule:MF_04083}.; SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Host endosome membrane {ECO:0000255|HAMAP-Rule:MF_04083}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04083}. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. {ECO:0000255|HAMAP-Rule:MF_04083}.
Interaction partners:
Sequence:
MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLKNDTNTNSSSGRMIMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYTLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSANFTDNAKTIIVQLNQSVEINCTRPNNNTRKSIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNNTLKQIDSKLREQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTKGSNNTEGSDTITLPCRIKQIINMWQEVGKAMYAPPISGQIRCSSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGKLICTTAVPWNASWSNKSLEQIWNNMTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSVVNRVRQGYSPLSFQTHLPIPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGAYRAIRHIPRRIRQGLERILL
Protein: Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (A0A1D8PL99)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS6A is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:35613268}.
Interaction partners:
- Small ribosomal subunit protein uS10
- Ubiquitin-ribosomal protein eS31 fusion protein
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein eL36
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein eL32
- Small ribosomal subunit protein uS17
- Large ribosomal subunit protein eL30
Sequence:
MKLNISYPANGTQKSIDIDDEHKLRVFYEKRMGQEVEGDSVGDEFKGYIFKITGGNDKQGFPMKQGVMHPTRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVAQDLSVLALSIVKQGDNEIEGLTDTTVPKRLGPKRANHIRKFFGLTKEDDVRDFVVRREVTKGDKTYTKAPKIQRLVTPQTLQRKRALKAKKVKNAQQQRDAAAEYAQLLAKRLHERKEERAEIKKKRAESLKN
Protein: Dosage compensation regulator mle (EC 3.6.4.13) (Protein male-less) (Protein maleless) (Protein no action potential) (P24785)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X-chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction.
Subcellular location: Nucleus {ECO:0000269|PubMed:1653648}. Chromosome {ECO:0000269|PubMed:1653648, ECO:0000269|PubMed:30649456, ECO:0000269|PubMed:30805612}. Note=Mle is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females, and is associated with 30-40 autosomal sites in both sexes. {ECO:0000269|PubMed:1653648, ECO:0000269|PubMed:30649456, ECO:0000269|PubMed:30805612}.
Interaction partners:
- Protein male-specific lethal-3
- E3 ubiquitin-protein ligase msl-2
- Protein male-specific lethal-1
- Histone acetyltransferase MOF
- Protein MBD-R2
- Chromosomal serine/threonine-protein kinase JIL-1
- Protein will die slowly
- Reduction in Cnn dots 1, isoform E
- NuA4 complex subunit EAF3 homolog
- GH01794p
Sequence:
MDIKSFLYQFCAKSQIEPKFDIRQTGPKNRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVNYLVRVGKLNTNDVPADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVKDLCVKSAGDFGLQRESGILPHQSRQFSDGGGPPKRGRFETGRFTNSSFGRRGNGRTFGGGYGNNGGGYGNNGGGYGNIGGGYGNNAGGYGNNGGYGNNGGGYRNNGGGYGNNGGGYGNKRGGFGDSFESNRGSGGGFRNGDQGGRWGNF
Protein: Acrosomal protein KIAA1210 (E9Q0C6)
Organism: Mus musculus (Mouse)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:28203736}. Note=Localizes to the sex body in spermatocyte, acrosome, and near the ectoplasmic specialization. {ECO:0000269|PubMed:28203736}.
Interaction partners:
- A-kinase anchor protein 17B
Sequence:
MEGFEASGEEGKKKSKFKAFKNFFSKKKKKEPEEIPEVAVLKPRFSSSSVSGSSLQPALEKQVMESKPKSGMGVKSISHDSVFCLDPEPEKGAGKLHSSPAPHRSKSLKIKSQRSQRLSISPLIRSEKVCEELEKFFASDRTTTTFRRRSSQCSSTPRMSSELSLDPETSESSTQQFSGFSTPATSQGCLDSSAAKSKIALNPRKQKKRKSTSTPVKVKQEEQLQSVPAKEKTTTKTKEAEQGEQKVDSTELSSQEQSSKTETQDTAVDKTPSTDPALRLNPRRRRRRAKNEWEILERGLLKSTQRYSLNTKAESSANKEIAGKEHSFLKLLLEKKDIGQPTTTEAEVTTVQKMPSDKGDVERELADIDVEAQKEPAPQPTSTDVAESMISGPSPHCEDKKKKDKVGVLPWIKKSTSQKEVTVLRKEEVQVHVHPSRVCGEGEEASCPELQRVQPQMKVSLESTTYHKEKHPRSGLPVPSTSISSATAEDDVSPKMNLPLPLRRRPNTGETSSDSKSTSEYESSSEMQLSPAHSFKPTRKPKDDAGAGTADDEEDGDDEKEEKDNDDDDEENVFLKSENVDVEVSKMEKQQALRYSSKLLGKPKAREASAKLESSSEDERSCEEMTSAHSSQSLEEFEECSESRGFIRGSISEERPATRCHSQALQELEEKEVSTESSSYIEKYESSEDLSSSEQEQQVPPVSKSSLKQWSAPAKPVHPIQTAQQQPPAMVNISGGPKKSGEPLSPTQTVKSRLRSQSECQVLAEPEGVVAADWDILMQPPPRPRLEQEVSAGPELTVFEKSIAVQPSGYPPQPSVKPSIKKEISLGAESAPLESPPPQHHFQPLLKPFVKQQVSAFERVISMDPKLPTQFQPRMKPQGKQSFSSTPESTAFEGSTSVDHMTLTLSQPMLQPYQEVPLESETVAAKMISTGQLHSKYSAHPLSSHQSQPVPESTSAEGEELLPSQPSVTPKFQPLMTQGSIPSAWAIPIYSPAPRMDSKPLMGSAIALESKPSRYSLQPWQSTPFEQVSVTPDHDPAAAAASWSPPIDPPTSRIPSQPLMRLAVKQPTCTELASVSVSQSSSLERLSSRFPFQPRADPEHYGAEEGVATLRRSRRHHSQSPVRSEFKEEVSSGSRRAFGERSISVGKMPPKYALQPWLCPEFQQQAKEGDVLRKAWLSGHPSQTISKHKVEKTPLPPKCPSPFLTRSKVQEISSRLESVIAQESSKKPQRGRPPSKSFVNFMAQQVFSESAPSKVVLHPKPVARGRRRPSRSLLKPKLDDYAFLYNWDNEPKEDTTLQNLPMKQPFQLSRKPEEPQEVLPFSEGAPVKWNTSARGISQALGKLSVSVSLPNEWKSSEGQLPSTQPSQAFDVAKLQSPVLPVDSANVPVKWRISEGHQPPQSFFVDYQPQVSVDSASAAAKGASCWPMLKDSASTTNVKYSQGYKDFTKSTPTSVIKPATFTSAPAQKPMVSMGTYFKDEVPKCCDETGTSSLLPTSKADVENVFGVRLRSTSQKIGMKNPDPCKPFVLISAAARKEQANKGDLQGSVGGSKQSRPAFSFEKKQGNWPRYEGTLKKSEVFRPPVAFYDQKMLHPRTRERLTRRSLSLPPTLPQREEPEWFSVAKKKAQAWSQIANIMQ
Protein: Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (Monomeric carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (B2GV72)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O75828}.
Interaction partners:
- Carbonyl reductase 2
- Cytochrome P450 1A1
- Cytochrome P450 2E1
- Carbonyl reductase
- Carbonyl reductase 1])
- Carbonyl reductase 2.
- Prostamide/prostaglandin F synthase
- UDP-glucuronosyltransferase 2B37
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase 1A1
Sequence:
MSSCSRVALVTGANKGIGFAITRDLCRKFSGDVVLTARDEARGRAAVKQLQAEGLSPRFHQLDIDNPQSIRALRDFLRKEYGGLNVLVNNAGIAFRMDDPTPFDVQAEVTLKTNFFATRNVCTELLPIMKPHGRVVNVSSLQGLKALENCSEDLQERFRCDTLTEGDLVDLMKKFVEDTKNEVHEREGWPDSAYGVSKLGVTVLTRILARQLDEKRKADRILLNACCPGWVKTDMARDQGSRTVEEGAETPVYLALLPPDATEPHGQLVRDKVVQTW
Protein: Photosystem II 22 kDa protein, chloroplastic (CP22) (Q02060)
Organism: Spinacia oleracea (Spinach)
Function: Seems to be involved in non-photochemical quenching, a process maintains the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage.
Subcellular location: Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Extreme lateral location to the appressed thylakoid regions.
Interaction partners:
Sequence:
MAQAMLLMMPGVSTTNTIDLKRNALLKLQIQKIKPKSSTSNLFFSPLPSSSSSSSTVFKTLALFKSKAKAPKKVEKPKLKVEDGLFGTSGGIGFTKENELFVGRVAMIGFAASLLGEGITGKGILSQLNLETGIPIYEAEPLLLFFILFTLLGAIGALGDRGRFVDEPTTGLEKAVIPPGKDVRSALGLKTKGPLFGFTKSNELFVGRLAQLGFAFSLIGEIITGKGALAQLNIETGVPINEIEPLVLLNVVFFFIAAINPGTGKFITDDEEED
Protein: Stumps, isoform B (Q9VFH9)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MLLKVENIEMETFCCDNCGNVNNTSGSSASGFLGSPGYNMDDILIITAKHSERAYLRATFLKNHFDKITKQRGRKPFNFLHIKIDDGPFSEEIAHKYQNTALQIVILCPALLALPHSFLMTQLSAIIRVEKVLAILLDVSEEKVKEMHKSALPSYYKWRRCVVRDNDQVQISNILGIATDILGRALCQRPPCQDSSGGGGGGLSRSFSSCTEGFTVLPKKVKLGQNKVVALLAEPLEKNDTLKLQVEKSGELIELRNFKCRNPYTLQFNIPEACMEISTMIEIRIEKNNKSLGARPIKCESRLRELEQLLRIEDSPIEFMCHALGIGPVERDALDQHLLQCFQRNMPPNFHLLSGPSERQPHFFTRLESSPEEYPTLLHFAARWGLNRLCIQLMECPGGDTACGVRNCAGRTPAELAEQEGHHKLAQNIVSFAEFHELTTMYHYFKGVTPPGESCPKPSANVVIEAHPVKAGKTNKPPKELPTAEYMEMSSGSERENTPEVRTKTETLAISNLNYISVETEDENLQASVAEKKVESEKKLPEAGNQPGPEKTTNELRINEPPYYQSKEQNQQPKELKNQSKSLDEVDAAPLYQTDKFSQECSQLLENQLGNDYVLQPSNVPVAQDDGNYLFQPSNRPVEEPLRLNRCTNRQPGYGTLKRSASDASAASHTRSNADDELAEIMHDFKNNVLSIRDVEVLVERWKHRNDVQQSFREKQDQIDQLRREYERIQEQVKSHLKRETPFERIKKFFLRSKTPGGNDSLLDETKSSIATSCSFKSAGGVSSSAGAGRPISSLSLQSVSSSSSSSGRLSTGSNCSGASLGDSGTHSDHEDRRFPHCRMMDNYMVPPTPRPVFTPSSTPGDERHQIVFPSPMSSCQRLNTPTSPTGSEHYQMFPSNIPVYGSQPLVGSQSSNYLNTIMEAKEQAETQHYQNQNGVTLQPIKLNERSNIIYGKLTKSSSASGCSSFKPKQIPVPCPQVGSIEVQAEVYQNVGDVAPEKDSKAEEETPNYMNC
Protein: Shk1 kinase-binding protein 15 (O74453)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Negatively regulates pak1/shk1 kinase activity leading to proper execution of cytoskeletal remodeling and cytokinetic functions.
Interaction partners:
- Ribosome biogenesis protein rlp24
- Ribosome production factor 2 homolog
- Serine/threonine-protein kinase shk1/pak1
- 60S ribosome subunit biogenesis protein nip7
- Ribosome biogenesis protein brx1
- 25S rRNA
- Probable nucleolar GTP-binding protein 1
- U3 small nucleolar ribonucleoprotein protein imp4
- Probable rRNA-processing protein ebp2
- rRNA-processing protein utp23
Sequence:
MLRFVVGTYTHLIYGVDADIERKKCKPLWLFEAHEGALTALAVDGIYLASTSSDETIKIFDHTRNVQIADVSVPTDIANACIRDMCFTKNHLLACHDNGQISMWSKGSWLLVHTLKSSSHKGITGIAVHPSEKLALTVGGDGKLRLWDLVRGKGGKVLPLSTIPESILFLNESSFVIMSRRGIDAFKLDLTSLFSFSSKSQLNALCLYQSKLIVGRDNGTVLVLDTSDGKILHEFTAHKKRVKSVYPVDDYLITASSDGSVCIWDKDWNLVIEHNIPEGNRITCMVAMLADSNSEPKNVEDEAAKRQSLDSETSETSSESESESEYYSTSKQPPVKRTKHA
Protein: WD repeat-containing protein 11 (F1QEB7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9BZH6}. Cytoplasm {ECO:0000250|UniProtKB:Q9BZH6}. Nucleus {ECO:0000250|UniProtKB:Q9BZH6}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:29263200}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9BZH6}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9BZH6}. Note=Shuttles from the cilium to the nucleus in response to Hh signaling. Might be shuttling between the nucleus and the cytoplasm. {ECO:0000250|UniProtKB:Q9BZH6}.
Interaction partners:
- Polymerase
- Kazal-type serine peptidase inhibitor domain 3
- Zgc:153240.
- Trafficking protein particle complex subunit 11
Sequence:
MASTMIPYTVNIKLAARTLTGTLNLQNKTAVDWGWQGLIAQGCHSSILIIDPNTAQTIQVLERHKANVVKVKWSRENYHHSLSSPYSLRLASADAAGKIIVWDVVSGMAHCEIQEHSKPIQDMDWLWAQDASRDLLLAVHPPNYIVLWNGDTGTKLWKKSYAENILSFSFDPFEPSNLALLTSEGIVFITDFSHSKPPGSGGKKVYIASPHSSPAHSKPAAAQPTGAKKALNKVKVLITNEKPTAEAVTLNDCLQLSYLPSKRNHMLLLYPREILILDLELSQTVGVVAIERSGVPFIQVIPCAQRDALYCLHENGCITLRVCRSTTPSPNETVTDPEQNSQELVYDLRSQCDAIRVTKTVRPYRVVICPVNENKAVLVVSDGRVMLWELKAHASKSSSNLSSGLPPLYSAVNFCGTPLRQNQKCIPDLSLNSMIGHSLIPGVDSPRPLADQKEVHLKFLLTGLLSGLPLPPFSLRMCPPLTTKNINHYQPLLAVGTSNGSVLVYNLTSGLLHKELSVHSCEVRGIEWISLTSFLSFATSVPNNLGLVRNELQHVDLRTGRCFAFRGERGNDEPAIEMIKVSHLKQYLVVVFRDKPLELWDVRTGTLLREMAKNFPTVTALEWSPSHNLKSLKKKQLAAREAMARQTTLADAEQSSVESSVISLLQDAESKSESSQGISAREHFVFTDTDGQVYHITVEGNTVKDGARIPPDGSMGSIACIAWKGDTLVLGDVDGNLNFWDLKARLSRGVPTHRGWVKKIRFAPGKGNQKLLVMYTDGAEVWDTKEVQMVSSIRVGRNVNYRILDIDWCTSDKVVLASDDGCVRVLEMAMKSASYRMDEQDLTDPVWCPYLLLPRAALTLKAFLLLQPWMDTFTMDITQVDYKEKDEIKGLIQEQLNSLSNDIKSVLQDPNLSLLQRCLLVSRLFGDESDLQFWTVASHYIQAFAQSAQSNESVPEGQAAASHLDICHDILCESSFFQGFQLERVRLQEVKRSSYEHTKKCADQLLLLGQTDRAVQLLLETSADNSSYYCDSLKACLVTTITSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWTRAAWLAKVRLNAAEGSDVLKRWAEHLCSPQVNQKSKAMLVLLSLGCFQKVGEMLHSMRYFDRAALFIEACLKYGVMETNDDINKLVGAAFVDYAKLLRSIGLKQGAVHWASRAGEAGKQLLEDLSQTEGTGTESSPADDTDNSLVNIE
Protein: Exocyst complex component 4 (Exocyst complex component Sec8) (Q9XWS2)
Organism: Caenorhabditis elegans
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Interaction partners:
- Exocyst complex component 5
- Exocyst complex component 1
- Exocyst component Exo84 C-terminal domain-containing protein
- Exocyst complex component 7
- Exocyst complex component 3
- Exocyst complex component 6
- Exocyst complex component 2
- Rab8
- RNA polymerase II-associated protein 3
- Myosin motor domain-containing protein
Sequence:
MNENGATPVAAARRHRPLPAERATSNSNETGLLINVIRSLTSSVSEDQREVEKSRLEKGYKESGALIDRLVKNHQQDVEKCLVSFRDVSSKISNCRERIHNVRNALHTVKSLLELRRDDLKKLWHENAQQKSVCEIMAKLEELREAPSKIENLISKEQYQQAADTVTESRELINGRLSRVEGLSHLSAEIERFTKILIDKINDTLVNMLVVEPFEKHLLHIVRTIPEHRINQNAYCHSLSTKSRSGSGSVSSFSDVSAKSRIVSSVEALSTLFRTVEERHWDVDRLMMLGKNMIDKMIVNTVQVMKIGANIDESNEGDTTHLKQLMQLLSAQFDSASQQHAEFGVLVEKQLGRKDVVTSFWRSAQSAIEVVVSEHLDINPLLEKQNVLGTASRKQLFRFENTACATPNANSSSHRTKAVICKPSAYNIKVIFPILSRLMETTEKNINDSPCELRRFMHSFVMEVFVERVKGELASRIEGALRGGEAVRVSTNKKILPSCEKVLNLCKEVQDLIVSIDLYADRFAALWLLVLTDYFKNMTDVYDRMTPKNPDPSLPNSEALPTRRQKISAAWTADDDISRLLMSLPNWHAASISPMTPAVESELDVGERNKRESEILIGNLGTQAQNSLSESDLITDMNDIKMFASLHESLRWFSDEIRELVHSLPANVKMMLDTCMVQVRLKDGQMIDNNSVPSAIEDCVRRLESIADSCLLLLHIEIRVHCFFHLAPLAKYRNTSSHNEVDPEVVALGKDLHQFHDNLKDVLSPAKLSYVFDGLGHLCASLFIHYSQFMPRLTEAAKKRVCRNVWGVQQRLSRITNRRESDLDRARAFFDLLLDNTPDGILAIVPEKRSQFTATELNYLLALSVRSDKTLASQPGALEKRQMVLNSILNQKK
Protein: Glycosyl hydrolase, putative (Q383L2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSSRDLRGRACSNSTAASASRLLCLPWELVEVELPKEMDVPVSESLFSVGNGRVTVRGYTEESLVAPPYSRGTNSHDIAIRSPVVSLYGGIGNDVIKVGNRSLSNSHLLGNPSSPVRCDSLPTEGHPTASKEWKPPERTLRGTYVNGICEELLLTHHQQQRAFTVGTCARESFLVCAPDAFCIDVFVGGEHVNSETGIILSHRRTLDYHTGELRRHLVWQSRSNGHEVTIESSRIVSLTRRSIAAVKYSVSAKNVSNTNIRIVSRTIVPSGVRQHLKIENVMTRRTLHDASTAVLVRTRNSCKRLVVAEFEACRSTHYELINTQSVPTFSTVTSAVGAHGANTPPCAVAADASLAAGRTPLASPKPMAQPQPQPTPSLTFLAPKCSEIRNGAETIYTSVIRESTRFELTKYIAFLVDEDAAPEDICDLGMHRAREAAAVTYEAICREQLDVLSNFWERGNVHIKASGPSLESAVRFNMLHLLMSSGGLQMQSHPSRGFMSQLQGGMHQWDVDAFIVPFFSHVRPEVARGLLQFRIDTLPQARSLAADVDLPRGALYPQRTVNGLESNPPPFCAAFLFTNAVVAYGMKQYITATNDFSILPQGGADVLFSTALIWLIWGTWDKAEFHVRSVGGPDDYSCLGDNNYFTNLMAKFHMQWAVQIAASMQRDYPNEWEGVKERCQLTDDDLAMMDKAAAKVVLVFDAKNRVHPVDQLFMRKKKWKFDELKKKKSLLFRTFDPSVVYRHQVCRIPDVVLASLLLPEKCTKDEVRANYNFYEPITTSDCSLTSMIFSIIAIQLDMLDKGMHYFHQALFNDIENALGNTARGIHCSSAAGSWWCLTVGFGGMRVVDDTLHFNPVLPDAWEEYQFFVRHHGCLIKVLITRRMVTYTAVEGCFDRCGLPIYHTEINTIHLKEGMSESVRLYRDVRVFDFDCVVFNLDSLIEDLEDHHYRAWKQTLEKYLHEMGQTSFVLTEDIYLAYLKNGNSFTSSQRLLAKNGITNIPPGCPDDTVETDTVYGLLQRKRHNFRVQIREEGLKVKKGALHLMAELRQNGISIGCVTDSKSGQWMLRRVPQVMCLIDRCIDGSDGEVLSLCWRPEVDYFCSLCKQLNTSFERTIVIMRGIGGFSKSALEQFKLVVDVQRDAEYVPGGVHPVNVPCMSVLTLGKLDEYASKRKLVAVAGDADRPATAPNNMEGAPPDQLE
Protein: Transmembrane protein 117 (Q9H0C3)
Organism: Homo sapiens (Human)
Function: Involved in endoplasmic reticulum (ER) stress-induced cell death pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27391701}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQRLFGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWMVTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLVITTDWISWDKLNRGFLPSDEVSRAFLASFILVFDLLIVMQDWEFPHFMGDVDVNLPGLHTPHMQFKIPFFQKIFKEEYRIHITGKWFNYGIIFLVLILDLNMWKNQIFYKPHEYGQYIGPGQKIYTVKDSESLKDLNRTKLSWEWRSNHTNPRTNKTYVEGDMFLHSRFIGASLDVKCLAFVPSLIAFVWFGFFIWFFGRFLKNEPRMENQDKTYTRMKRKSPSEHSKDMGITRENTQASVEDPLNDPSLVCIRSDFNEIVYKSSHLTSENLSSQLNESTSATEADQDPTTSKSTPTN
Protein: UDP-glucose 4-epimerase (EC 5.1.3.2) (C8VAU8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Interaction partners:
- Galactose-1-phosphate uridylyltransferase
- Galactokinase
- UDP-glucose 4-epimerase
- Cytosolic neutral trehalase
- Acid trehalase
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogen debranching enzyme
- Ribose 5-phosphate isomerase
- N-acetylglucosamine-6-phosphate deacetylase
- Phosphoacetylglucosamine mutase
Sequence:
MPSGSVLVTGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALNRIELISGKKAEFAQLDVTDEAAFDKVFEAHPDIDSVIHFAALKAVGESGEKPLDYYHVNVYGTICLLRSMVRHNVTNIVFSSSATVYGDATRFPDMIPIPEHCPLGPTNPYGNTKFAIELAITDVINAQRNNAKKAGNETEAAKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLLVFGDDYASHDGTAIRDYIHILDLADGHLKALNYLRANNPGVRAWNLGTGRGSTVYEMIRAFSKAVGRDLPYEVAPRRAGDVLNLTSNPTRANTELGWKAQRTLEQACEDLWLWTKNNPQGYRQQPPAELLEQLKK