wanglab/gogpt-training-data huggingface dataset:
Protein: Pollux (Q24193)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYNVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRKPIFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGGQSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDKFVANIKSPLEVDSGVGTPLSPPSTASNSSGGSIFSRMGYRTTPPALSPLAQRQSYGVAITTAPCPQHMEEVAPATTMAVMPQEDVEEPQPMHPLSMVGGDVNVRFKGTTQLKSIRPVHHMRAIPLGGVQHPSSTEPAVRVAPVPVELAPPAATATTGRS
Protein: AT24863p (Q86NU6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
ATVEATTEATTEATGEYEAEEDDEDEAAADDDAVESTEAPLSKAEEQEDDEDEDEEEQEIEESVEPERSQYAAQSAPAKDNNDDDDDDDQDKNDADDGDDDEFESLAQQFENDPEDTVPAKAVESEEQDQDQADEEEPKEEGSSWLASLAVKFGVGVALALVSRLVLIRKSPNTTEDEPAPETIFRRRLTIATAEDHIPDDVEELPPLDDEYSEEEIEIEEEIEVEISDIEEEEEEVRHDNDDNVASMASYVPETFEQLSAMYKYAQEPTKDAKPEQKEKEPEKPVGHSDIYVEYEDGAIEDYEHDGVSDEEITDEEDEISDVDDADLMNRLEAKYGRLPVKEFESDPDSDDPSWTRNY
Protein: Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) (Q91ZJ9)
Organism: Mus musculus (Mouse)
Function: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
Subcellular location: Secreted {ECO:0000250}. Lysosome {ECO:0000250}.
Interaction partners:
- Alpha-L-iduronidase
- Beta-glucuronidase
- Arylsulfatase B
- Hyaluronan synthase 2
- Hyaluronan synthase 1
- Hyaluronan synthase 3
Sequence:
MLGLTQHAQKVWRMKPFSPEVSPGSSPATAGHLLRISTLFLTLLELAQVCRGSVVSNRPFITVWNGDTHWCLTEYGVDVDVSVFDVVANKEQSFQGSNMTIFYREELGTYPYYTPTGEPVFGGLPQNASLVTHLAHTFQDIKAAMPEPDFSGLAVIDWEAWRPRWAFNWDSKDIYRQRSMELVQAEHPDWPETLVEAAAKNQFQEAAEAWMAGTLQLGQVLRPRGLWGYYGFPDCYNNDFLSLNYTGQCPVFVRDQNDQLGWLWNQSYALYPSIYLPAALMGTEKSQMYVRHRVQEALRVAIVSRDPHVPVMPYVQIFYEMTDYLLPLEELEHSLGESAAQGVAGAVLWLSSDKTSTKESCQAIKAYMDSTLGPFIVNVTSAALLCSEALCSGHGRCVRHPSYPEALLTLNPASFSIELTHDGRPPSLKGTLSLKDRAQMAMKFRCRCYRGWRGKWCDKRGM
Protein: Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9) (Q8BZ00)
Organism: Mus musculus (Mouse)
Function: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters. Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (By similarity). Regulates synaptic transmission by regulating the luminal pH of axonal endosomes. Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages. Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH.
Subcellular location: Late endosome membrane {ECO:0000250|UniProtKB:Q8IVB4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Cell membrane {ECO:0000269|PubMed:17005858}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Early endosome membrane {ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:29362376}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Recycling endosome membrane {ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:29362376}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Note=Localized to the plasma membrane in inner ear hair cell bundle (PubMed:17005858). Interacts with CHP1 (By similarity). {ECO:0000250|UniProtKB:D4A7H1, ECO:0000269|PubMed:17005858}.
Interaction partners:
Sequence:
MAGQLRFTSGKDEDHFQHQGAVELLAFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIDSGTVYNCGNLFFSPSTLLVNITDQVYEYKYQREINQHNISPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCVVIGLIMYGFVKAMVHAGQLKSGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDTAAFFQSVGNFLGIFAGSFAMGSAYAVVTALLTKFTKLREFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNNLSSDSKLRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDESLKEEPSSQQEANKLDKNMTKTESAQLFRMWYGFDHKYLKPILTHSGPPLTTTLPAWCGPVSRLLTSPQAYGEQLKEDDVECIVNQDELAMNYQEQSPSPSSPTTKLALDQKSSGQTPGKENIYEGDLGLGGYDLKLEQTRGQPQMD
Protein: (+)-alpha-pinene synthase, chloroplastic (EC 4.2.3.121) ((+)-(3R:5R)-alpha-pinene synthase) (Synthase II) (Q84KL3)
Organism: Pinus taeda (Loblolly pine)
Function: Involved in defensive oleoresin formation in conifers in response to insect attack or other injury. Involved in monoterpene (C10) olefins biosynthesis. Produces mainly (+)-alpha-pinene (97%) with a small amount of (-)-alpha-pinene (3%).
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Interaction partners:
Sequence:
MALVSAVPLNSKLCLRRTLFGFSHELKAIHSTVPNLGMCRGGKSIAPSMSMSSTTSVSNEDGVPRRIAGHHSNLWDDDSIASLSTSYEAPSYRKRADKLIGEVKNIFDLMSVEDGVFTSPLSDLHHRLWMVDSVERLGIDRHFKDEINSALDHVYSYWTEKGIGRGRESGVTDLNSTALGLRTLRLHGYTVSSHVLDHFKNEKGQFTCSAIQTEGEIRDVLNLFRASLIAFPGEKIMEAAEIFSTMYLKDALQKIPPSGLSQEIEYLLEFGWHTNLPRMETRMYIDVFGEDTTFETPYLIREKLLELAKLEFNIFHSLVKRELQSLSRWWKDYGFPEITFSRHRHVEYYTLAACIANDPKHSAFRLGFGKISHMITILDDIYDTFGTMEELKLLTAAFKRWDPSSIECLPDYMKGVYMAVYDNINEMAREAQKIQGWDTVSYARKSWEAFIGAYIQEAKWISSGYLPTFDEYLENGKVSFGSRITTLEPMLTLGFPLPPRILQEIDFPSKFNDLICAILRLKGDTQCYKADRARGEEASAVSCYMKDHPGITEEDAVNQVNAMVDNLTKELNWELLRPDSGVPISYKKVAFDICRVFHYGYKYRDGFSVASIEIKNLVTRTVVETVPL
Protein: Vang-like protein (A0A0B4KEN4)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
- Frizzled-3
- Segment polarity protein dishevelled
- Protein espinas
- Frizzled
- Protein prickle
- Diego, isoform A
- Protocadherin-like wing polarity protein stan
- Dishevelled associated activator of morphogenesis, isoform D
- Rho-associated protein kinase
- Extracellular serine/threonine protein kinase four-jointed
Sequence:
MENESVKSEHSGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRERDRSRHSHRSTHSSKSAKGFQRGDMAPYQTSVNMTGDGSHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSISMEDINNMWHRESDKGFSFACRRYVESSFYFLLGCGAFFSPVAMVVMPYVGFFPSAFDHPEITQTVRTQLLACSEQCKGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLFYIVQVTNGAKIVVETGGDAVDYKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRSPDGVSRSYMLGQLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEVDGVSNSQQQSQSRAVLAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNEPAPALPLDPQEAASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTESPVMQSEKERRWVQSWSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSNKFVLKLNSETSVXHHHNAPPINTPTHSNQTQSSYLHVFV
Protein: Nuclear factor Y-box C (RE43755p) (Q9W3V9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Nuclear transcription factor Y subunit
- Nuclear factor Y-box B, isoform A
- DNA polymerase epsilon subunit 3
- Grain, isoform C
Sequence:
MYATNNGGTNKAPNSNATSMFDNTITVTPIKMELGQAYAKSQNSAAMQRRTPNAVVVTSSSTVSSAQQQQQQQGQQQQQTVPMASLVSNACTLVNPSMSVTVATTVASGAKEKTTKATRTQVARKPPPTIDNFWPNIVSEVHSIGQVDAKHQVLPLARIKKIMKLDENAKMIAGEAPLLFAKACEYFIQELTMHAWVHTEESRRRTLQRSDIAQAIANYDQFDFLIDIVPREEIKPSSAQKTKDGSTSSSSGMAGAASSAASTSNTATSNAAASVAGNATATGNFVASGSTVPATTAGGLKLDTTGATNAAEVLGFSTVNSDIFSAQLQQQQQQQQQHAAQQQQQQQQQQHHQAHPQQVQIIQQGAGGQQLQYFIALPSQQAAQLVQQPQPAQNHLPINILSTQQPTQQLILTAGPNGQLTATPAPQTTAQQQTALLQNLAQQQQQHQQHQQQIQLLQQVVTPTGELTNVPIAINASHLNLLQRLQMQQQQQQQQQQQQQQQQQQQVIIPTQLLTTQQLLQLGGAPTVAHQQQQQQQQHANLTQQSNASAVASGTPIFINSTMTGAQAAATQAQQQQSAQQQQAQTISTMSTDRTLTGGFR
Protein: Fe(2+) transport protein 1 (Fe(II) transport protein 1) (Iron-regulated transporter 1) (OsIRT1) (Q75HB1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Iron transporter involved in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. May also transport other divalent cations.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16412081}; Multi-pass membrane protein {ECO:0000269|PubMed:16412081}.
Interaction partners:
Sequence:
MATPRTLVPILPPVAALLLLLVAASSIPILAAAQPADACGGAPDQAAADGACHDVPRALRLKLIAIPTILVSSVVGVCLPLLSRSVPALRPDGGLFAVVKAFASGVILATGYMHVLPDAFNNLTSPCLPRKPWSEFPFAAFVAMLAAVSTLMADSLMLTYYNRSKPRPSSGGDVAAVADHGESPDQGHRHGHGHGHGHGMAVAKPDDVEATQVQLRRNRVVVQVLEIGIVVHSVVIGLGMGASQNVCTIRPLVAAMCFHQMFEGMGLGGCILQAEYGRRMRSVLVFFFSTTTPFGIALGLALTRVYRDNSPTALIVVGLLNAASAGLLHYMALVELLAADFMGPKLQGNVRLQLAAFLAVLLGAGGMSVMAKWA
Protein: CRM-domain containing factor CFM3, chloroplastic/mitochondrial (Protein CRM FAMILY MEMBER 3) (ZmCFM3) (A7XN92)
Organism: Zea mays (Maize)
Function: Binds specific group II introns in chloroplasts and facilitates their splicing. Acts on subgroup IIB introns. The substrates of the subgroup IIB also require the CRM domain proteins CAF1 or CAF2, with a simultaneous binding of CFM3 and CAF1 or CAF2. May influence the biogenesis of the mitochondrial small ribosomal subunit (By similarity).
Subcellular location: Plastid, chloroplast stroma {ECO:0000269|PubMed:18799595}. Mitochondrion {ECO:0000269|PubMed:18799595}.
Interaction partners:
- Protein WHAT'S THIS FACTOR 1
- Ribonuclease III domain-containing protein RNC1, chloroplastic
- Chloroplastic group IIB intron splicing facilitator CRS2, chloroplastic
- Chloroplast RNA splicing2
- peptidyl-tRNA hydrolase
- CRS2-associated factor 2, chloroplastic
- RNA-binding KH domain-containing protein
Sequence:
MAMASSPACHFRHPPRLRLLLPLSTSAPHPWLYSWSHPRQRGRLRAPPAALDLRPEPSPSSDSDDEDAVGASRSSGRSTMSLILSRLRRAGYSGEDPRAAAPPHPPRGSVEDVFRADDGVLPNARGGFDADDEERALGDARFPWERPMPPPEAAPRSARSPTWMAELTLPAAELRRLRHAAIRIKSRTKVGGAGVTREIVEKIKEKWKTEEVVRVKVSGTPALNMRLFHEILERKTGGLVIWRSGTSVSLYRGVDYDEPEPTKKSKKNSQSLAMDFPIKGSSNPSLLPTETANSVRDSNVALVSNAAKEELVVQAPEIKYEDEIDKLLDELGPRYTDWPGSDPLPVDADLLPANMPGYKPPFRVLPYGVRPSLSRRDTTNLRRLARGLPPHFALGRSRQLQGLANAMVKLWEKSSIAKIALKRGVQLTTSERMAEDIKKLTGGVMLSRNNEFIVFYRGKDFLSSELAEVLLERERLAKSLQDEEEARRKAASYFSSAETYAQPTVAGTLGETLEANSKYGTKHDENHADKMARTIEAARHADLVRKLEWKLSLAQKKMEKAERVLGKVETALRPTEDSRPPETITDEERFMFRKLGLRMKAFLLLGRRGVFDGTIENMHLHWKYRELVKILVKAKSFADVKRIALSLEAESGGILVSVDKVSKGYAIVVFRGKNYRRPSSLRPRNLLSKRKALARSIELQRHQALSRHFAKLNRKVERLKAELVQMEDVKEQGDEELYAKLDAAYSSDDEDMEDEDDEAYLKRFDNEVAGATADDDGSDDYTSAADEADYPDSDDEAGDCSEDEGEDDEDEAAAGVSDAGFHGEVVGFSSDTDRRNHDVNEY
Protein: Solute carrier family 25, member 27, isoform CRA_c (Uncoupling protein UCP-4, isoform b) (Q9EPH6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
Interaction partners:
Sequence:
MPFPEEESLQPLTQRWPRTSKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALAKLGDGAMESAPYRGMMRTALGIVQEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRRLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWIPNIQRAALVNMGDLTTYDTVKHYLVLNTALEDNIATHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCVIQAVQGEGFLSLYKGFLPSWLRMEDTLLHRDCDLQGATLYPSLETGVLSDSSFYLRAICLVQSHETNH
Protein: GM01975p (Q8T9L0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MGYIFHETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPSSSQQQYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIISEIRETHMW
Protein: Rho GTPase activating protein at 71E, isoform C (Q9VUR6)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MSSWAERVHRRAADLGNVVTSCGHPATAPAYPYRLEKVKFGVPLEEVCKHNNNIPGPLLVLILKLNKESPNRRDVFRAPGHQGAMKKLIHFLQAGRLVNVDNYSVFTIASVLKKFLRKIPNGIFGRSGEMELFAINDLQNEAEQTERLHRLFGSLPKYTQHLLVLLFGTFRVIASNAAHASTGMTSEALGVSVAPSFFQSCVSDGKTARMEDVLKFKVSTKIMQNIIDKFATHDIFGRDNYEYYARVTGRILKVQDEWICSFQYPPPPRGKLAQQKYALQHSLEAEKTWLQCQCERWGLLAQEESRSTPALLTSSSSALENSVLSLGVSPEHSFIESCARLSVSLEGPGIYAMTSSPLPAKRNGNGNGNATDYDYDDYADDDEDNDELDGVHDFGAELEISSIAPPQGSRGIYRHKQRAQQQPHHYQQQQQQQQVPPQHQRDYDEDDDDDEDEMTFIKRRYRQNKKKPAPPSSSHHQRRLRTGTKSLDGGGERRTGSGAAGGSGGGASGSAVGNPTPPKLKQRTCSRCNRGIRHSSSCSSNSAGATGSNSGGGGNGGSGAGNGGGAEGGMTMEELRAVNRYAESTKSLSYLPQVHERQTARMRTRSEWFLGPRDAVVTLQLPADTCSNCCLAAAAGYLGGGSTRDMRQAQTEGERNQAALLYHFYRRQQQQQQQQQEQHYDDMMDTEDSYGQQKEQQHQQQQQQEQQQQHIHSKGLLRPPPMQHQHQQQQQQRRLLLDVNSVGNIRLSNSAESIQYAARRPVASLGLNPSLGGAITTINTTSTHNPTTRRLLINVPRQYRSSLRRNKEKQIGGNSQSNSSNSLGSDQLTGNAGAAAGSAVGVPVLNKPLLMVGLLPGAEQPPSVRNSIAECGISTPDAMDVGMECSTTLSFKPPRL
Protein: Ferredoxin, chloroplastic (P07839)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Subcellular location: Plastid, chloroplast.
Interaction partners:
Sequence:
MAMAMRSTFAARVGAKPAVRGARPASRMSCMAYKVTLKTPSGDKTIECPADTYILDAAEEAGLDLPYSCRAGACSSCAGKVAAGTVDQSDQSFLDDAQMGNGFVLTCVAYPTSDCTIQTHQEEALY
Protein: Multiple wing hairs, isoform C (M9PE53)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Actin-interacting protein 1
- Ras-like GTP-binding protein Rho1
- Protein inturned
Sequence:
MGNRIASSRGADGAGEGAAGEGNSRFNTRRRYQQHKREYCLQNEYRSKTLPARHPHHSDPHQSHQKCSAQERLGSSSCLGAGQNASNNATPHNGETSRVLFLLYLIHRTWNVVMDTMDSRTKSSRSARGNSPQKEGPVDIELQPRVLDEECSIGITDLDASSFCSQYSCCSCSYCDVETTGTQTNVYSSIGDDFSLDSMFEAGKSMVDSDSSTLQRHHPQPRHPGQLGQLHLEMAPSVCEMAGQGQSGPVPPQKASGSNSSKGTNKCGASSLNGSLASYKIGGSEQSWPQAPVYSKENQRPPVYNPEDYVHSLRKFIKASGSAKKLSIYDVFTGPSPKEEASRSATLPAKHSEYKSPIPAPPENDREMSLRQFGSITDLLTKLRADLRVSFPSFVQEFVGTPADGISHLLEVLRAIQMAQASNAPAPMPGASSSLAMNRNPQSYQRRALLDELSCLQCLSICCSRSLDAIARLGNTPVGLMPLASSATGQGIRARILALQLLASACDRQPFGSGSGGQKIASAGHTAVSDAMSTLRLRCSEPVRFRLLVGILNSGGGSGELQCAGVKFLNTFIESAVSIQQRLYIQAELFQAGLDASTLARTISSSSPWLDALKIEVKRFNELHIDVDQMITRARDAERVRSQMVILERRVQILHEEKAVLTSMERRLQERCAELQREIFRLQGTQQQSKFKPVESSHQPVALPRQVPPPKKNKQNSSEHEDEGISSSETGASLSPVPILILPSKAKPSRKVVEEDEDDAATIEDVIEELDNIVSEAEKQISSQTSSVTRPKMRHHRPVEKEIVPVNIVPQPPRKSRSLAHLVPRTDCSDQEGSDYGMVLHQPADPDAAERLAAMQSFFDEVDYDAPETDQPAAYQMESPTPDMPEANATATAYNASTNRELLDVIMNARHDDHDPTMQALRKSVQDAAPVTIPHHPVKVKAPAPPPPTPPAQQFNGVFFMTGMNTPQKYPKPDISAALQARRVTKNVERLEAAFASAHPEALNEAAIGREKSRSNQQIYFTSNLAMRMHDHSGFANSSGGQIQGPTLRTRSHTQGSMSKVTDLPSGLY
Protein: Dolichyl-phosphate-mannose--protein mannosyltransferase 2 (EC 2.4.1.109) (P31382)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT2 and more rarely with PMT5 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. The PMT1-PMT2 complex participates in oxidative protein folding, ER-associated protein degradation (ERAD), as well as ER export.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P33775}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Dolichyl-phosphate-mannose--protein mannosyltransferase 1
- Protein MEH1
- Dolichyl-phosphate-mannose--protein mannosyltransferase 3
- Dolichyl-phosphate-mannose--protein mannosyltransferase 5
- Dolichyl-phosphate-mannose--protein mannosyltransferase 4
- Probable alpha-1,6-mannosyltransferase MNN10
- Mannan polymerase I complex VAN1 subunit
- Mannan polymerase complexes subunit MNN9
- Mannan polymerase II complex ANP1 subunit
- Putative glycosyltransferase HOC1
Sequence:
MSSSSSTGYSKNNAAHIKQENTLRQRESSSISVSEELSSADERDAEDFSKEKPAAQSSLLRLESVVMPVIFTALALFTRMYKIGINNHVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSWDFPSGEIYPDYLDYVKMRLFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVMFHNQRSKPFSRKWWKWLLITGISLGCTISVKMVGLFIITMVGIYTVIDLWTFLADKSMSWKTYINHWLARIFGLIIVPFCIFLLCFKIHFDLLSHSGTGDANMPSLFQARLVGSDVGQGPRDIALGSSVVSIKNQALGGSLLHSHIQTYPDGSNQQQVTCYGYKDANNEWFFNRERGLPSWSENETDIEYLKPGTSYRLVHKSTGRNLHTHPVAAPVSKTQWEVSGYGDNVVGDNKDNWVIEIMDQRGDEDPEKLHTLTTSFRIKNLEMGCYLAQTGNSLPEWGFRQQEVVCMKNPFKRDKRTWWNIETHENERLPPRPEDFQYPKTNFLKDFIHLNLAMMATNNALVPDPDKFDYLASSAWQWPTLNVGLRLCGWGDDNPKYFLLGTPASTWASSVAVLAFMATVVILLIRWQRQYVDLRNPSNWNVFLMGGFYPLLAWGLHYMPFVIMSRVTYVHHYLPALYFALIILAYCFDAGLQKWSRSKCGRIMRFVLYAGFMALVIGCFWYFSPISFGMEGPSSNFRYLNWFSTWDIADKQEA
Protein: ADAM metallopeptidase domain 22 (F1M542)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MQAVAAAFFWLLCVLGTYPLARCGRAGDASLRELERGDGNRFLERQSTVPLRLIYRLGGEDETQHEQLNTRVRGDPGGRQPTHVDKASFRVDAFGTSFILDVLLNHELLSSGYVERHIEHGGKVVENKGGEHCYYQGQIRGNPASFVALSTCHGLHGMFYDGNHTYLIEPEENEMSQESQFHSVYKSRLLEFPLDDLPSEFQRINITAPQFTLKPRLKRRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYKDQLKTRIVLVAMETWAADNKFAISENPLVTLREFMKYRRDFIKEKADAVHLFSGSQFESSRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDCDIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYCYEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGFLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPMASFNFSTCLSNKAGTVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNVGGNKKKIRGKRFRPRSNSTEYLNPWFKRDYNVAKWVEDVNRNTEGPYFRTLSPAKSPSSSTGSIASSRKYPYPMPPLPDEEKTVNRQSARLWETSI
Protein: UTP14, U3 small nucleolar ribonucleoprotein, homolog C (Yeast) (Q08E77)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
Sequence:
MNVNQVAENLALSHQEQLVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPRKDKNLPNVIISEKRNIHAAAHQVQVLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTPKVVTKPGHIIKPIKAEDVGYQSSSRSDLPVIQRNPKRITTRHNKEEKL
Protein: Tubulin beta-2 chain (Beta-2-tubulin) (P61857)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton.
Interaction partners:
- Tubulin alpha-1 chain
- Tubulin alpha-3 chain
- AT04270p
- Tubulin alpha-2 chain
- Tubulin alpha-4 chain
- Histone-like protein 18C
- Cytosol aminopeptidase
- Serine/threonine-protein kinase CG17528
- non-specific serine/threonine protein kinase
- GH09231p
Sequence:
MREIVHIQAGQCGNQIGGKFWEVISDEHCIDATGTYYGDSDLQLERINVYYNEATGAKYVPRAILVDLEPGTMDSVRSGAFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNIQNKNSSFFVEWIPNNCKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADEEGEFDEDEEGGGDE
Protein: Zinc metalloprotease Rip1 (EC 3.4.24.-) (Regulator of sigma KLM proteases) (S2P endopeptidase) (Site-2 protease Rip1) (S2P protease Rip1) (Site-2-type intramembrane protease) (P9WHS3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: A probable intramembrane site-2 protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains. Cleaves PbpB (PBP3, FtsI) near 'Ala-102' and 'Ala-103' in response to oxidative stress; cleavage is inhibited by Wag31-PbpB interaction. Probably also cleaves anti-sigma factors RskA, RslA and RsmA but not RsdA.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase
- Glutamate synthase large chain
- 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
- GCN5-related N-acetyltransferase
- Phosphatidate cytidylyltransferase
Sequence:
MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGPTLWSTRRGETEYGVKAVPLGGFCDIAGMTPVEELDPDERDRAMYKQATWKRVAVLFAGPGMNLAICLVLIYAIALVWGLPNLHPPTRAVIGETGCVAQEVSQGKLEQCTGPGPAALAGIRSGDVVVKVGDTPVSSFDEMAAAVRKSHGSVPIVVERDGTAIVTYVDIESTQRWIPNGQGGELQPATVGAIGVGAARVGPVRYGVFSAMPATFAVTGDLTVEVGKALAALPTKVGALVRAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFFLAQLNLILAAINLLPLLPFDGGHIAVAVFERIRNMVRSARGKVAAAPVNYLKLLPATYVVLVLVVGYMLLTVTADLVNPIRLFQ
Protein: Alpha-1,2-mannosyltransferase MNN21 (EC 2.4.1.-) (Q59KJ7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Interaction partners:
- Alpha-1,6-mannosyltransferase
- Anp1p
- Mannan polymerase complex subunit MNN9
- Alpha-1,6-mannosyltransferase
- Glutamyl-tRNA
- Alpha-1,6-mannosyltransferase
Sequence:
MFQQLTYRLRLFRRRHKYIFINSIFLSVIIIFLIYSYWSNLPAEDNSAIINEKGTYHRSLWESITMALFPPKTKPFEEKKPQVNPNNNQEVGVESGASEISQHKQQQQQQQHAKEPTTKTSSKSLVSDEAYQLNLKLINEQQEKYNRLHPFEQKRLQQGYEFFDNIFKIFYQAKPSVSQLNTYPSKKRIYHARFDSLADDDTIFSEKYLSQFLQLSNEELAAMKKSHKYVVENLPEDAPDGLYKKNGIVYVAGGSFNWLTLLSIKSLRAVGCHLPIEVFIPKIEEYESDLCNRILPELDARCIYMKNQLMNPNKDNSDSFANKFEFKGYQYKALAILLSSFENVLLLDSDNIPAHSPEELFENDPFKSYGLVVWPDYWKRATSPYYYNIADIDVSEKYLGSKYNEVEGQYTDLSVEKGSVELDKIPLHQRLGSIPDPTSESGQLLISKKTHLKPLLLALYYNLYGPSHYYPLFSQGSDGEGDKETFLAATVTLGKRYYQVAKFLVSLGHFKVPGGDFEGCGMGQFDPQQDLEYIKLREQYAKIPEKDKEKQHKFKLQHQVLEKGPEILFVHANFPKLNPWKLKQEKKIFDAKGNRVRLYGPGMIKRIGYDFEWFQWEGMKYLLCIYDVNLQIFQDVKKSDLCDEILEHLRFLESTQNITD
Protein: ATP synthase gamma chain 2, chloroplastic (F-ATPase gamma subunit 2) (Q01909)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Interaction partners:
- ATP synthase subunit beta, chloroplastic
- ATP synthase subunit b, chloroplastic
- ATP synthase subunit d, mitochondrial
- ATP synthase epsilon chain, chloroplastic
- ATP synthase subunit alpha, chloroplastic
- ATP synthase subunit alpha
- ATP synthase subunit c, chloroplastic
- ATP synthase subunit O, mitochondrial
- ATP synthase subunit alpha
- ATP synthase subunit beta-2, mitochondrial
Sequence:
MTGSISTSWLLSSPSNSNSASSSESYSFIATLKPVRYYPFQSLTPNRISSRSPLPSIQIRAGIRELRERIDSVKNTQKITEAMRLVAAARVRRAQDAVIKGRPFTETLVEILYSINQSAQLEDIDFPLSIVRPVKRVALVVVTGDKGLCGGFNNAVTKKATLRVQELKQRGIDCVVISVGKKGNAYFSRRDEFDVDKCIEGGGVFPTTKEAQVIADDVFSLFVSEEVDKVELVYTKFVSLVKSDPVIHTLLPLSMKGESCDVKGECVDAIEDEMFRLTSKDGKLAVERTKLEVEKPEISPLMQFEQDPVQILDAMMPLYLNSQILRALQESLASELASRMNAMSNATDNAVELKKNLTMAYNRARQAKITGELLEIVAGAEALRES
Protein: Mediator complex subunit 1 (A0A8I6G510)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MKAQGETEESEKLSKMSSLLDRLHAKFNQSRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGAVQSLCSS