wanglab/gogpt-training-data huggingface dataset:
Protein: Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) (P18203)
Organism: Bos taurus (Bovine)
Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62942}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P62943}; Peripheral membrane protein {ECO:0000250|UniProtKB:P62943}; Cytoplasmic side {ECO:0000250|UniProtKB:P62943}.
Interaction partners:
- TGF-beta receptor type-1
- Ryanodine receptor 1.
- Ribosomal protein S6 kinase beta-1
- Eukaryotic translation initiation factor 4E
- Eukaryotic translation initiation factor 4E-binding protein 1
- Target of rapamycin complex subunit LST8
- CALML5 protein
- EF-hand domain-containing protein
- Calmodulin
- EF-hand calcium-binding domain-containing protein 11
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFVLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPNATLIFDVELLKLE
Protein: RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RAD9, RAD1, HUS1-interacting nuclear orphan protein) (Q9BSD3)
Organism: Homo sapiens (Human)
Function: Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.
Subcellular location: Nucleus {ECO:0000269|PubMed:20811708}. Chromosome {ECO:0000269|PubMed:20811708, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:25602520, ECO:0000269|PubMed:37440612}. Note=Localizes to sites of DNA damage in a H2AX-independent manner. {ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:37440612}.
Interaction partners:
- Cell cycle checkpoint protein RAD1
- Checkpoint protein HUS1
- DNA topoisomerase 2-binding protein 1
- Cell cycle checkpoint control protein RAD9A
- Claspin
- Serine/threonine-protein kinase Chk1
- Fanconi anemia group J protein
- Breast cancer type 1 susceptibility protein
Sequence:
MPPRKKRRQPSQKAPLLFHQQPLEGPKHSCASTQLPITHTRQVPSKPIDHSTITSWVSPDFDTAAGSLFPAYQKHQNRARHSSRKPTTSKFPHLTFESPQSSSSETLGIPLIRECPSESEKDVSRRPLVPVLSPQSCGNMSVQALQSLPYVFIPPDIQTPESSSVKEELIPQDQKENSLLSCTLHTGTPNSPEPGPVLVKDTPEDKYGIKVTWRRRQHLLAYLRERGKLSRSQFLVKS
Protein: Mitoguardin 1 (F8W7S1)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
Interaction partners:
Sequence:
MSEETVSESQFSLKTAALRVFDLPLTWYYSLSQIKFSPVAKKLFVVTAVSAISVIFLAHHFKRKRGKKKGKILPWEPEHLILEYTKRAASDKGSSCSSSRQNLTLSLSSTKDKGSQVCNYANGGLFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRNRQAEDEACGSIKLGAGDAIAEENVDDIISTEFIHKLEALLQRAYRLQEEFEATLGASDPNSLADDIDKDTDITMKGNVEDFGLRDTLSIASTDSFASAAELAEHREVRHTYSLESLCHCPFYEEAMHLVEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQVILSESANRIFLAESGRKILSALIVKARKNPKKFEDVFDEMIYFLEQTDHWGSTEMELAARGVKNLNFYDVVLDFILMDSFEDLENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKQIPDGFFAHFYAICEHISPVLAWGFLGPRNSLYDLCCFFKNQVLLFLKDIFDFEKVRYSSTETLAEDLMQLLIRRTELLMAYLEADALRHTSSCLSSHGHVMSTGLLEAKVQ
Protein: Ornithine decarboxylase antizyme 3 (A8MW57)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
LPCKRCRPSVYSLSYIKRGKTRNYLYPIWSPYAYYLYCYKYRITLREKMLPRCYKSITYKEEEDLTLQPRSCLQCSESLVGLQEGKSTEQGNHDQLKELYSAGNLTVLATDPLLHQDPVQLDFHFRLTSQTSAHWHGLLCDRRLFLDIPYQALDQGNRESLTATLEYVEEKTNVDSVFVNFQNDRNDRGALLRAFSYMGFEVVRPDHPALPPLDNVIFMVYPLERDVGHLPSEPP
Protein: Synaptic vesicle membrane protein VAT-1 homolog-like (EC 1.-.-.-) (Q9HCJ6)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAKEGVEKAEETEQMIEKEAGKEPAEGGGGDGSHRLGDAQEMRAVVLAGFGGLNKLRLFRKAMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVMAFVNYNAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIKDSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKVIAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLILDVEKTPTPLMANDSTETSEAGEEEEDHEGDSENKERMPFIQ
Protein: RIC3 acetylcholine receptor chaperone, isoform D (Q9W2N3)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Interaction partners:
Sequence:
MPATATSKPRAPLVEEGMTPKKTALIIVTVIGCIAILWPKVFHPMMFGGVPPSQPNFKDPRAAPGGLRQERPAHLHPESIYQAMRERGRAIPATPTVPILERKTSPSNPPPRIVDGRPGPIPGMRPPMGAGALHQPQQRGSSMGFLMPLYTIGIVVFFGYTLMKIMFKKQVPNDPYGAAPPNPAFRQEVFGSQNHSQVEDLGGSKLGAATATAAAKKPAAKDTEKELYNASVSATEVASSLSASLKSHQQLKEAEQLMEIEKLRQKLESTERAMAQLVAEMNTDQYEAKKNDNEKTREQPLDKQNLSNGHASSTDQNPEQETVAKGARKRRDLSAEQELTVLGMELTASCEGGHKWTGRPPTPVFRAPSEHSKLEDNLPEPQSIYLEGALAHESQILVADSQIKREEVYDSELNGSAEEPAIILSSRMTLSLINLDANQQNGNAGKSAVESPLADDIEIIGHDEQ
Protein: Photoactivated adenylate cyclase subunit beta-like protein 1224-5/1F (P84742)
Organism: Euglena gracilis
Subcellular location: Cell projection, cilium, flagellum {ECO:0000269|PubMed:16121285}. Note=Paraxonemal body. And paraxonemal bodies (PABs).
Interaction partners:
Sequence:
MYILVWKKGQQIKTFHTLDEAAQFKAASNIDEAQVFSVTDAPDISASGGSNEARNRRRLMYLTNSTNPEECNPQFVGEMARVATIQNREIGARGFLMYSCRFLLQVIEETVEDPDSLFAKFSPEPRHERWIELDNGPCTGRMYGDWNMKDSHLDSITTHPAMLTILFQMARSISCLWSYLQKSERIMLLFGKDPGAQRPEPMRVVVTFTYLVDFGSMLSIPNLTEQAAEVLTTFVDGCVKNVEGSGGSIAKFTTGICMAQWPINRTVEALTAIQQISEDLAQLRSQQAPGSAVSLMYSQAGLHYGRGMLCNAGSRKSDFTLLDFINTTSRIATLANKLKTPLLFHSFDVRCLLGDEMREEIEGAGMHQVKGRDKPVGVYQFPGPELDVEMVLRQKVEQFTPGRFRCQMPVVEYEALPIWQRPPIVDDTPKGYPRPRTMPGYGGRQRSDSLVDRLIMIAKLAGPSVSATGDTTLTTLTYISQATRKPMSRLHLSALMGTATRRNAQQSITGTLLDVNGLFGQTLEGPKVAVVMYLSIRQDARQTDVTTVHMAPLQERVCPSEWTLTSATEEMLATFPPLQDVLSQLAKSCTSLETYVRSTVGYLTAGNNRRNLMPVSCGVVMLATDIGSFTSLTEESSLTEVWMICNTFIDACTSAVCQEGGEVIKRIGDCVTAYFPGNNAESAVAAAQELFTFCRQLREAFVDVVDVRGCVSCGVGLDYSQVVMAQCGSLGLTEYVVAGVSARVMEVDAMTREVGYAIGVTEPYVTDRLSPQSRDHGIVPTPQAIELPCYGIAGEQLELDVDSIKRGIKALHAARSGEMPVTEPEEALRLFRVSPGRVRHGDTGRRSNSAQGKRSIQVR
Protein: Death-associated inhibitor of apoptosis 2 (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (Q24307)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel-mediated induction of antimicrobial peptides. Anti-apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses rpr and hid-dependent cell death in the eye. However, has also been shown to have little, if any, role in the regulation of the canonical caspase-dependent apoptosis pathway. Plays a role in regulating the expression of ion channels.
Subcellular location: Nucleus {ECO:0000269|PubMed:24374974}. Cytoplasm {ECO:0000269|PubMed:24374974}.
Interaction partners:
- Protein immune deficiency
- Caspase-8
- Neural/ectodermal development factor IMP-L2
- Caspase drICE
- LD40663p
- Mitogen-activated protein kinase kinase kinase 7
- Death-associated inhibitor of apoptosis 1
- Insulin-like receptor
- AT03047p
- Serine protease HTRA2, mitochondrial
Sequence:
MTELGMELESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPICSMVLAPNHCGNVPRSQESDNEGNSVVDSPESCSCPDLLLEANRLVTFKDWPNPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNLDELGIQPTTLPLRPKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEVLATTAANASSQPATAPAPTLQADVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFVRTFLS
Protein: Zinc finger protein CONSTANS-LIKE 7 (Q9C9A9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00357}.
Interaction partners:
- B-box zinc finger family protein
- B-box zinc finger protein 18
- D-ribose-binding periplasmic protein
- B-box domain protein 31
- B-box zinc finger protein 32
- Putative zinc finger protein At1g68190
- B-box zinc finger protein 21
Sequence:
MVVDVESRTASVTGEKMAARGCDACMKRSRASWYCPADDAFLCQSCDASIHSANHLAKRHERVRLQSSSPTETADKTTSVWYEGFRRKARTPRSKSCAFEKLLQIESNDPLVPELGGDEDDGFFSFSSVEETEESLNCCVPVFDPFSDMLIDDINGFCLVPDEVNNTTTNGELGEVEKAIMDDEGFMGFVPLDMDLEDLTMDVESLLEEEQLCLGFKEPNDVGVIKEENKVGFEINCKDLKRVKDEDEEEEEAKCENGGSKDSDREASNDKDRKTSLFLRLDYGAVISAWDNHGSPWKTGIKPECMLGGNTCLPHVVGGYEKLMSSDGSVTRQQGRDGGGSDGEREARVLRYKEKRRTRLFSKKIRYEVRKLNAEQRPRIKGRFVKRTSLLT
Protein: GID complex substrate-recognition subunit 10 (Glucose-induced degradation protein 10) (P53242)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- GID complex subunit 5
- GID complex subunit 1
- GID complex subunit 8
- GID complex subunit 7
- GID complex substrate-recognition subunit 4
- E3 ubiquitin-protein ligase RMD5
- GID complex subunit 9
- Malate dehydrogenase, cytoplasmic
- Solute carrier RCH1
Sequence:
MTSLNIMGRKFILERAKRNDNIEEIYTSAYVSLPSSTDTRLPHFKAKEEDCDVYEEGTNLVGKNAKYTYRSLGRHLDFLRPGLRFGGSQSSKYTYYTVEVKIDTVNLPLYKDSRSLDPHVTGTFTIKNLTPVLDKVVTLFEGYVINYNQFPLCSLHWPAEETLDPYMAQRESDCSHWKRFGHFGSDNWSLTERNFGQYNHESAEFMNQRYIYLKWKERFLLDDEEQENLMLDDNHHLEGASFEGFYYVCLDQLTGSVEGYYYHPACELFQKLELVPTNCDALNTYSSGFEIA
Protein: Hepatocyte nuclear factor 3-gamma (HNF-3-gamma) (HNF-3G) (Forkhead box protein A3) (P32183)
Organism: Rattus norvegicus (Rat)
Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Hepatocyte nuclear factor 4-alpha
- Hepatocyte nuclear factor 1-alpha
Sequence:
MLGSVKMEAHDLAEWSYYPEAGEVYSPVNPVPTMAPLNSYMSLNPLSSPYPPGGLQASPLPTGPLAPPAPTAPLGPTFPGLGAGSGTGGSASGYGAPGPGLVHGKEMAKGYRRPLTHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKAKKGNSATSATRNGTVGSATSATTTAATAVTSPAQPQPTPPSEPEAQSGEDVGGLDCASPPSSAPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQTSTPSKLDVGFGGYGAESGEPGVYYQSLYSRSLLNAS
Protein: Protein strawberry notch homolog (Lethal protein 765) (Notch signaling pathway homolog 1) (O01737)
Organism: Caenorhabditis elegans
Function: Transcriptional activator that functions upstream of the let-60/Ras and let-23/EGFR signaling pathways to positively regulate lin-3 expression and thereby promote vulval induction. Plays a role in excretory duct development. Plays a role in male tail development.
Subcellular location: Nucleus {ECO:0000269|PubMed:20230814}.
Interaction partners:
- SNF2 N-terminal domain-containing protein
- SNF2 N-terminal domain-containing protein
- SNF2 N-terminal domain-containing protein
- SNF2 N-terminal domain-containing protein
- ATP-dependent RNA helicase SUV3 homolog, mitochondrial
Sequence:
MDDILSAALAESGLDFLCQQSSPTPSTSGSIHDDAGQSFSNNTHTPSVSQFFDETSNDSHSSSAYYTPMATPFVSTEDGGVPTSFFGMDEEDGGCTIMTTAGTSGSNNIDGIEDAGGGMYYPHVKVIPRKHTAPTVNQSEPSTPTVTIVPKKEDPLFETNTADSPTPSGDTSTTASYEGNDGLEDQETTSDRQNPMFVQTARSTDGRLDTPSTSATVSPHITSSLTQRSHTSSPASSASEGTVVPPRKKGLPITTGSIVKRTVQTKDGLQTQYLKAFVNENGEKIYKLLSPVAASAVARGTLPPGMGRGGSTIGRGGTMVNKNGERLMVVKNHVGPNGQMLVKRMVSPAGTRIVANGGQGRGQPIYRAVDGSNGPTHLLRRTTTTGQPTRGAPVGMAARHAVRGGTVYGGGNGYRVNLVGRGTGGSTMVHHQPLNRISSQRSVAPVGRVLNRGALRNGAQQPLHVSTSSPAFHYMEEQPSPTTNGMVIQAKTPGAGVIQARHMQSQQSFPSGGPARVLMNRSSTNAGLSRMVGGGYDQQLPTAPNGRLMIPSTAVRVPGSGMASPRLQTTPQPLTKSQKAKDEMKMAYQVGREEALQQRRNDLEDDEENLGYAETYSEYTPAKLRSGMAHPDSVVESASLSSVSPPDVKYQISIPEYLIDMGHISALQLEAVIYACQMHERRMPSGERYGYLIGDGAGVGKGRTVACIIFENYLQGRKRAIWLSVSSDLKFDAERDLRDCGAPNIPVYALNKMKYAKISGKENGSIKKGVMFATYTSLIGECRGAKSRKYRSRISQLIQWFGQDYDGVIILDECHRAKNLVPTAGAKPTKTGRMVLELQKALPNARVVYASATGATEPRNMAYMTRLGLWGERQAFPEFHDFISAVERRGVGAMEIVAMDMKQRGLYLARQLSFRGVSFAVQEVQLSSEFVKMYDAAVKLWMEARRQFQTVIETMDEEERSTCKTVWGQFWACHQRFFKYLCIAAKVDTCVQLSREAIKAKKCVVIGLQSTGESATLETLEEMGGELNEFVSTAKTVLYGLIDKHFPTDASFSMGDRDIFKDFDDFERPAKRRKTRETLSFLGDVGFDTWTGVTTGMGGRVGDGVTKNITRGLSGIGRSSMSSSTGNTNNEDANSTTSESSDGSDDEVENDMISENGGESGDLESAREEAEGARTLEDGEQDEWVKALLAEAESSSDDSDEEVVKDEDEDEEAESKSGETHEQEEEFNPFMCDFTNDDPWAHNQQIVEDTPQKDRKAKKRKRDEEEAERLREKVRKREERREKKRRRAIRRAEREKQRRNEELQARGSATDFITSSRICGNGSGEQDDINPMLIKTELLAAVERLAPSLPANTLDQLIDEMGGPEYVAEMTGRRGHMVTSETGDVMYQRRNANAEVSLELINMEEKEKFMRGEKLIAIISEAASSGISLQSDRRAINKRRRVHITLELPWSADKAIQQFGRTHRSNQVSGPEYVFLISELAGEKRFASIVAKRLESLGALTHGDRRATETRDLSQFNMDNKYGRVALDTLLKTVIGQAGTPLIDPPKDYKAGEFFEDMRLYMEGVGLLAKNKTGQYTIEKEAATIPKFLNRILGLPVHAQNSLFHYFSEIVAELIAQSKHDGTYDTGIMDLGTGDDQVRKLETRVFTGRVDNGSFRVEIHKIGVERGVSWEEAMELHKEHSNDDDGFYICHPGGANTANTKKVAALVYGIGKIRMDNGARLYAITRPSTGRSPKLMTMADLSKRFHKVSIDEAKEVWKQQYDSAANMCQHNYVYGKCRTESNGTYCEVGRRTRTYFVLSGSVLSVWPIVEEVLAGSDRKSSRMQVIRVRTEQDQKIVGLLVLPTHVRHLVQQLETHCGRSYVKTEP
Protein: Janus kinase and microtubule-interacting protein 1 (Multiple alpha helices and RNA-linker protein 1) (Marlin-1) (Q3SWS9)
Organism: Rattus norvegicus (Rat)
Function: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
Subcellular location: Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.
Interaction partners:
Sequence:
MSKKGRSKGEKPETETDSVQMANEELRAKLTNIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREALIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLADAREEARRTFDGERQRLQQEILELKAARKQAEEALSNCMQADKAKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKERVILALEKELGVQAGQTQRLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMAELMGGQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLHSIQRMEEKLKSLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDETTTREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDAAWVEEKQVLMRTNQDLLEKIYRLEMEENQLKSEMQDAKDQNELLEFRVLELEVRDSICCKLSNGADILFEPKLKFV
Protein: DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa) (Q9UGP5)
Organism: Homo sapiens (Human)
Function: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:10887191}. Chromosome {ECO:0000269|PubMed:30250067}. Note=Accumulates at sites of DNA damage. {ECO:0000269|PubMed:30250067}.
Interaction partners:
- DNA repair protein REV1
- Terminal nucleotidyltransferase 4A
- DNA repair protein XRCC4
- F-box/WD repeat-containing protein 4
- E3 ubiquitin-protein ligase RAD18
- DNA ligase 4
- X-ray repair cross-complementing protein 6
- X-ray repair cross-complementing protein 5
- DNA polymerase zeta catalytic subunit
- DNA-dependent protein kinase catalytic subunit
Sequence:
MDPRGILKAFPKRQKIHADASSKVLAKIPRREEGEEAEEWLSSLRAHVVRTGIGRARAELFEKQIVQHGGQLCPAQGPGVTHIVVDEGMDYERALRLLRLPQLPPGAQLVKSAWLSLCLQERRLVDVAGFSIFIPSRYLDHPQPSKAEQDASIPPGTHEALLQTALSPPPPPTRPVSPPQKAKEAPNTQAQPISDDEASDGEETQVSAADLEALISGHYPTSLEGDCEPSPAPAVLDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
Protein: DNA repair protein RAD51 homolog 4 (AtRAD51D) (Q9LQQ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- DNA repair protein XRCC2 homolog
- At4g33925
- Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A
- DNA repair protein XRCC3 homolog
- DNA repair protein RAD51 homolog 3
- ATP-dependent DNA helicase Q-like 4A
- Protein CHROMATIN REMODELING 25
- Negative regulator of systemic acquired resistance SNI1
- DNA repair protein RAD51 homolog 2
- ATP-dependent DNA helicase Q-like 4B
Sequence:
MAPLKHLEKENPIIDACFQDFCASHGILTIEDFLLHDLYELTAFSQRQTNADRLKEGITLILSLIERQCRPLVNGLKLLEDLHRNKHTLSTGDKETDSLLQGGFREGQLTELVGPSSSGKTQFCMQAAASVAENHLGRVLYLDTGNSFSARRIAQFICSSSDATLGQKVMSRILCHTVYDIYTLFDTLQDLEITLRLQMNVNESRLRLLVVDSISSLITPILGGSGSQGRALMVAIGYLLKKLAHEHSIAILVTNHTVGAGGEGGKTKPALGETWKSIPHVRLSLSRDHKNSNCTISILKHTSLPSGQAAKTLTRKENQQCP
Protein: LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein (A0A1D8PMQ3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Interaction partners:
Sequence:
MYNKYSSIRKLRKPLILLLIFNTLYLSFYHYFGNNDSQLTLLNIPLDSTNLLAEYATTDANYTKEVDELIASIEPPIVTSEYRIPKRTNQIFQDPRLTFGLILNYVNQNPSSSIPFHWADWVDLSLLNNQLNKPIEKRLKCLDILNHIHLQFDKDRELCRENTRYFGCADSESLSASELQEYGVDSHEQLPGFIQFEHTVFSSTEYVRNLQGKTYVLASMPIPYKVIFMNDKGEDLVFDVHKERIDKLKDNYKKSKIDPVVEFEKLTQGSNSYKPKPIIDIPLSDFEYEKEFVLESIKNLEAKPELNQRQKSYLWSMKKSIAIQESSDSETRYFNEATMTVGNGNEDSGWHYDWRFFNGKLRDGARTAIILERLLRNWFRFTEKYGVVSWIAHGPLLSWYWNGAIFPYDNDLDVQMPIKQLARLGELYNQTLVVEDLREGFGKYLIDVGTFIHNRDISNDGNHIDARFIDVDTGVYIDITGLSNVLVNRASRYDGRDIHDRRKHFYKLNDLAPVKLSMLNGVPCYISNHIVQNLKREYRSGISRKQYQDYIFSNKLNIWVHTSVLAEALEKNDYINSSGNISHLQMKFLIDEMTDDQIYQMLSNNNQLLLDYQLARSVRKFHAKELKYLTSFTNKGRAIDNDDITEEYKNLLGTVTLHEPFRESLFEYERVNGGLDTFYEEYNREIDSLTVS
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A8WFS2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Kinesin-like protein kif7
- Suppressor of fused homolog.
- Kinesin family member 21B
- Protein smoothened
- G kinase-anchoring protein 1
- GLI family zinc finger 3.
- Radial spoke head 1 homolog
- Radial spoke head protein 9 homolog
Sequence:
MDQYHILEVIGEGSFGRVYKGRRKFSGQVVALKFIPKVGRSEKDLRSLKREIDIMRGLKHPNIVLLLDSFETEREVVVVTEYAEGELFQILEDDGSLPEKQVREIACQLVSALYYLHSHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSVSTLVLTSIKGTPLYMSPELVEEKPYDHSTDLWSLGCILYELHTGAPPFYTNSIFQLVQLIVRDPVKWPDNMSQDCLSFLKGLLMKEPEKRLSWPDLLHHPFVADGVLMVSDEGSSNPLTVPPSPDVQALKHQQVAEKTTVRSGEGKLLGKARELREKEKTNRREVASGSAARCKTASAGGASNTGHSLGSTFSVYQNSSQPATNRHQANDNSVTRARSAPHKGQISRDYAREFPSVEVGPRQFLKRPGHEQDMDSDYEWQRLVELSDQGPVNASILQGLKIKLLQAKTQLLVRKGEETSSILLPLKVLRNIVQGCRIGDVETVGKELELPHLLFSLIEDVLNIPDLMQESQGETVLADLMSVLIMYLEKSPGWEIKGRRAEDLCQLFISVFLSGDPKRSALLAAAVLTLFTQRGVSVNVGIEKLTAVLGDVLTYTEAHNPLPAGWGLCDGLLSLILHRLAECESSSLLDFQQSDLWPCLWAKVNIMLQNTPSQSCHFSPNGLYMFLSLALLLFSSDPYTCVTLLSDNTTNCSSTLGHLLTTSCSASLLERGLFWGDSEINSLSVMSCHLLCIPFSLDLPLEKHLSVLQSYQSSNIVAGLVQMIQTIPIALVELPLCLLNRLLLSDPQHTTPCLITAAQASAFLPHGTESSDNGADHTQTQLKHSGNGVERSKSNGIVKKTKIDHIKGDIKSKKSLDRPTGDVDASRDKNSSQNAPSRNIRQTKVKSQAKTYPTKAMEHLRDASKIGHIEELMDSLEIHGSSAGLSPQQGCGISMLIDSLEEFRRSGDRPKTSIRSSPEEARTAGSLLALLLQSEALSGCAVELLILLSLLTRHPTYQSSFFLPVEFTQLRLALLHRDDGIRAACCSLLGHLGLCVIRVINEPKFDLFQDLLGCLCDPAPSVRRAACKAVGNWLNEIRKTSDNIPSKGLKSTTDMQTWSVQDKPRRTEGVRYMEADVWMQLAIGAARPLVSLLSDADNVIRQHCCGALANLAAFSGGDGALLNADAPGLILQTACNDSHHAVRRAAVATLRVFSQQNTLLQALRSLDAGRKLCRSSQSSLFQRDYQWLVSKLDGSVEGKT
Protein: Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3) (Q62521)
Organism: Mus musculus (Mouse)
Function: Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
Subcellular location: Nucleus {ECO:0000269|PubMed:11238441}. Cytoplasm {ECO:0000269|PubMed:11238441}. Note=Translocation to the nucleus requires KPNA1 or KPNA6 (By similarity). Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}.
Interaction partners:
- Homeobox protein NANOG
- Transcription factor SOX-2
- POU domain, class 5, transcription factor 1
- Cryptic protein
Sequence:
MTMLLDGGPQFPGLGVGSFGAPRHHEMPNREPAGMGLNPFGDSTHAAAAAAAAAAFKLSPATAHDLSSGQSSAFTPQGSGYANALGHHHHHHHHHHASQVPTYGGAASAAFNSTRDFLFRQRGSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTDPYAASAQFPNYSPMNMNMGVNVAAHHGPGAFFRYMRQPIKQELSCKWIEEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESSTPPAIASANSKDTTKTPSAVQTSTSHNPGLPPNFNEWYV
Protein: Rhamnogalacturonate lyase B (EC 4.2.2.23) (Q5AZ85)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Degrades the rhamnogalacturonan I (RG-I) backbone of pectin. Active against linseed rhamnogalacturonan.
Subcellular location: Secreted {ECO:0000250}.
Interaction partners:
- Pre-mRNA-splicing factor clf1
- Pre-mRNA-splicing factor syf1
- Cell cycle control protein Cwf14/Bud31, putative
- Pre-mRNA-splicing factor slt11
- Pre-mRNA-splicing factor isy1
- Pre-mRNA-splicing factor cef1
- Pre-mRNA-splicing factor
- Peptidyl-prolyl cis-trans isomerase-like 1
- Pre-mRNA-splicing factor cwc22
- Pre-mRNA-splicing factor cwc15
Sequence:
MRLGVCFSLAAAASVARAALTATENDTSIVLENDRLRATFDKGRGSIIDLYLDGQDFLGPQSGSTGIGPYLDCYCTPSGFYTAGSTNPVTELVQGTDSTGTKYAGIILNDTYTPTGQEFQQYWFLRDGETGFHMFSRLAYYNETTPFLRNLQELRTLFRPNTDLWTHLTSSDLQTAPLPSDEAIAEQIVVQDATWRLNNTPDDAYYQQFSEYFTKYTFSNHWRDNDVHGLYADGSTSDGTTYGAWLVMNTKDTYYGGPLHSDLTVDGIIYNYIVSNHHGEGTPNITNGFDRTFGPQFYLFNGGGSSSLEELRDEARSLASPSWNADFYDSIAKHVIGYVPSSQRGSVKGTIKLPKNAKSPIAVLTVDGHYFQDNSAVPSSHQYWADIDKNGRFSIDRVVAGKYRLTVYADGIFGDFTRDGIVVKARKSTSIKETWKPESAGTEIWRLGTPDKSSGEFRHGAARDPTHPRHPPEYLIYWGAYDWQSDFPGGIDYMIGESDPATDFNTVHWAVFGPTPDNPVAESNTTHDWRIRFDLSAKQLHARKTATLTIQLAGAKAASGNTDVYNASEPYANLPLRSYINEQEEPLTMVIGYDQSSSCIVRSAVSCYQVREKWEFPASWLKEGSNLLRLSLPTNGTNYESAVLPTSVYVQYDALRLELK