wanglab/gogpt-training-data huggingface dataset:
Protein: Centrosome and spindle pole associated protein 1 (B2RX88)
Organism: Mus musculus (Mouse)
Function: May play a role in cell-cycle-dependent microtubule organization.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q1MSJ5}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19129481}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19129481}. Cell projection, cilium {ECO:0000250|UniProtKB:Q1MSJ5}. Note=Associated with mitotic spindles. {ECO:0000250|UniProtKB:Q1MSJ5}.
Interaction partners:
Sequence:
MADSLDEFIEEQKAKLAKDKAELESDPPYMEMKGKASEKLSENSKILISMAKENIPPSSQQQPKGPLGIEYGLSLPLGEDYEQKKHKLKEELRQDYRRYLTQGITQAKRKKNFLSTGETDPSTLGVSLPIDERLSAKERLKLERNREYNQFLRGKAESTEKVRQVEKNIEPKSQRNKNPISQGKSDLPLQIQTAYTHSEGPWLSRQEEGLYRQLDGEIELRSRRPLKQTKEEVGISGAEHPSLSGSAGVPERRARRANGERVLDRQHCRADRDPGVSEDMDERFRFESDFDRRLLRVYTNGRPHGSRRGYVDGDDVPEEPNTQISAAENKSVHCNGPPRSADLDITSPFAGMLFGGEDRELTKRRKEKYRQELLEQIAEQQKKKRREKDLAFGITTSGVQDPEKSPDRLKQFSLTPRHFEEMPPERPRVAFQTPPPPFSAPSSPSVPPVHSAPSHNEDLHSGLGSTLGELAHPRVLPVPLNPPPPPLLAPPASNYRTPYDDAYYFYGARNTLDPNIVYYGSGMIGGQPAPHVSAPVTHQVAPPAVNTVGQNEQKVLSDGLRNSGLVFEDKPKPSTQSLQSYQEALQEQIREREARRKKERLEKEEYEAKLEAEMRIYNPWGKGGGGAPLRDAKGNLITDLNRMHRQNIDAYHNPDARTYEDKRAVVSIDQNLATSNAENLEDSANKNSGPLQTQSSPFARGNTFGEPLSELQIKQQELYKNFLRFQIEEKRQREEAEREKLRVAEEKEEKRLAEQRARIQQEYEEEQERRREKEEEQRLKNEELIRLAEERRKEAERKKKEEEEKHNLQLQHYYERENIIGDETKHLRQPSPVVPALQNKIASKLQRPPSVDTIISSFIHESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQLRSEERRLQGRLLHLDSDDEIPMRKRERNPMDIFDMARHRVQAPVRRPSPKGLDATTFQNIHDFNELRERDSDTRVDLRLMYPDPPRDHHTLEIQQQALLREQQKRLNRIKMRRDAGADLDTICTDNAQGRRMPRDDTNDFLKNSLLESDSAFIGAYGETYPVIEDNAFPPPSQLPSARERRRNKLKGLDFDSSRLHTPQDGLSLKSISSVNVDQVRMRNEDRMRRLTEQQKKPTNTDDEGSLVDPDDIMRHLSDDGRNSAATEPWLRPGTSESLKRFMAEHLNEEQHKGPGKPGTFTWQGLSAAHA
Protein: Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7) (P83436)
Organism: Homo sapiens (Human)
Function: Required for normal Golgi function.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:11980916}; Peripheral membrane protein {ECO:0000269|PubMed:11980916}.
Interaction partners:
- Conserved oligomeric Golgi complex subunit 8
- Conserved oligomeric Golgi complex subunit 1
- Conserved oligomeric Golgi complex subunit 3
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 5
- Conserved oligomeric Golgi complex subunit 4
- Conserved oligomeric Golgi complex subunit 2
- Golgin subfamily A member 5
- Vacuolar protein sorting-associated protein 53 homolog
- Golgi SNAP receptor complex member 1
Sequence:
MDFSKFLADDFDVKEWINAAFRAGSKEAASGKADGHAATLVMKLQLFIQEVNHAVEETSHQALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTSQSMQVLVEIDQVKSRMQLAAESLQEADKWSTLSADIEETFKTQDIAVISAKLTGMQNSLMMLVDTPDYSEKCVHLEALKNRLEALASPQIVAAFTSQAVDQSKVFVKVFTEIDRMPQLLAYYYKCHKVQLLAAWQELCQSDLSLDRQLTGLYDALLGAWHTQIQWATQVFQKPHEVVMVLLIQTLGALMPSLPSCLSNGVERAGPEQELTRLLEFYDATAHFAKGLEMALLPHLHEHNLVKVTELVDAVYDPYKPYQLKYGDMEESNLLIQMSAVPLEHGEVIDCVQELSHSVNKLFGLASAAVDRCVRFTNGLGTCGLLSALKSLFAKYVSDFTSTLQSIRKKCKLDHIPPNSLFQEDWTAFQNSIRIIATCGELLRHCGDFEQQLANRILSTAGKYLSDSCSPRSLAGFQESILTDKKNSAKNPWQEYNYLQKDNPAEYASLMEILYTLKEKGSSNHNLLAAPRAALTRLNQQAHQLAFDSVFLRIKQQLLLISKMDSWNTAGIGETLTDELPAFSLTPLEYISNIGQYIMSLPLNLEPFVTQEDSALELALHAGKLPFPPEQGDELPELDNMADNWLGSIARATMQTYCDAILQIPELSPHSAKQLATDIDYLINVMDALGLQPSRTLQHIVTLLKTRPEDYRQVSKGLPRRLATTVATMRSVNY
Protein: Uncharacterized protein Rv1480 (P9WLX5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- UPF0353 protein Rv1481
- Chaperone MoxR1
- Phosphoribosylamine--glycine ligase
- Histidine N-alpha-methyltransferase
- ATPase BagB
Sequence:
MTESKAPAVVHPPSMLRGDIDDPKLAAALRTLELTVKQKLDGVLHGDHLGLIPGPGSEPGESRLYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWLVVDMSASLDFGTACCEKRDLAVAAAAAITFLNSGGGNRLGALIANGAAMTRVPARTGRQHQHTMLRTIATMPQAPAGVRGDLAVAIDALRRPERRRGMAVIISDFLGPINWMRPLRAIAARHEVLAIEVLDPRDVELPDVGDVVLQDAESGVVREFSIDPALRDDFARAAAAHRADVARTIRGCGAPLLSLRTDRDWLADIVRFVASRRRGALAGHQ
Protein: Semaphorin-5A (Semaphorin-F) (Sema F) (Q13591)
Organism: Homo sapiens (Human)
Function: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Subcellular location: Membrane; Single-pass type I membrane protein.
Interaction partners:
- Plexin-B3
- Semaphorin-5B
- Plexin-A1
- Taste receptor type 2 member 1
- Plexin-A3
- Plexin-B1
- Cadherin-9
- Cadherin-10
Sequence:
MKGTCVIAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWSEWSDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMIAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAPLNTSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY
Protein: Alpha-amylase 3 (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) (Q9Y7S9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in cell wall biosynthesis where it is involved in maintaining cell wall strength and shape.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Interaction partners:
- Probable glucoamylase
- Putative invertase
- Invertase
- Cell wall alpha-1,3-glucan synthase mok12
Sequence:
MFGVYFVLLFLSSALIHVANAGSNAEWRKRIIYQILTDRFAVDDGSTDNPCDPDANQYCGGTWKGIENKLDYIEDMGFNAIWISPIDKNIEGDIDGAGYAYHGYWNTDYESLNEHFGTEDDLVSLITAAHKAGIWVMLDSIVNSMALAPPLADADYSSLNPFNKESYFHPYCLIDWDITDNETNVMDCWQDSGVLLADLDVESSDVSSYLSDHFKSLISKYDFDGLRIDAVKMMNYTFFPDFVDATGVYSVGEVFSYDPDTMCSYMSVLPGVTNYFLQLYINFSFTATGAGFTLIPTYQEVMASNCSKYDSTLMLTFIENHDLYRFPYYTSDQSQIMGALSFVLIWDGIPSIFYGQEQGFNGGEDPANRPALWLTDYDQSNPYYTVIKTMVAFRKFVITQDPDWVTSTYQSIESAVDHYVGQKNDVLVMFNNMGVTNNLTIYEVETNYTANEVVSDVFGHRTLTVGADKTLTASMTNGYPLIMYPHSKMSGFTLPTVNRTVMPSTSATATTTVYTSYYSPSYSARSFTGTGSIFTISSSSRLILSFKTLVFGLGVTAMLFVLFF
Protein: Mixed-amyrin synthase (EC 5.4.99.39) (EC 5.4.99.40) (Q9LRH7)
Organism: Pisum sativum (Garden pea) (Lathyrus oleraceus)
Function: Multifunctional oxidosqualene cyclase producing alpha- and beta-amyrin and several other minor triterpenes.
Interaction partners:
Sequence:
MWKLKIGDGGKDRNIFSTNNFVGRQTWEFDPDAGTSQEKAQVEAARQHFYDNRFEVKACSDLLWRFQILKEKNFKQTIESVKIKDEEEISEENVAITLRRAVHHLSTLQSNDGHWPALNAGPLFYFPPLVFCMYVTGHLDSIFPYEYRKEILRYIYCHQNEDGGWGLHVEGHSIMFCTVLNYICMRILGEGPNGGKEDACARARKWIHDHGSVTHVSSWGKIWLSVLGIFDWCASNPMPPEFWMLPSFLLKHPAKMLCYCRLVYMPMSYLYGKRFVGPITPLILMLREELLTQPYEKVNWKKTRHLCAKEDLYYPHPLIQDLIWDSLYIFVEPLLTHWPFNKLLREKALQTVMKHIHYEDENSRYITIGCVEKVLCILACWVEDPNGDAFKKHLARLPDYLWVSEDGMTLHSFGSQTWDASLIIQALLATNLIEDVGPILTKAHEFIKKSQVRDNPSGDFKSMYRHISKGSWTFSDKDHGWQVSDCTAESLKCCLLLSMLPPEIVGEKMEPEMLYDSVNILLSLQGKKGGLPAWEPSEAVEWLELFNPIEFLEEIVVEREYVECTSSAIQALVLFKKLYPEHRKKEVENFIANAVRFLEYKQTSDGSWYGNWGICFTYGSWFALNGLVAAGKTYDNCAAIRKGVEFLLTTQREDGGWGESHLSSSKKIYVPLERSQSNIVQTSWAIMGLIHAGQMERDPTPLHRAVKLIINFQQEEGDWPQQELTGVFMKNCMLQYAMYRDIFPTWALAEYRRRILLASPAVAI
Protein: Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 (EC 2.7.12.1) (Dual specificity Yak1-related kinase mbk-1) (Minibrain Kinase 1) (Q8WQL7)
Organism: Caenorhabditis elegans
Function: Possible role in the function of olfactory neurons.
Subcellular location: Nucleus {ECO:0000269|PubMed:12618396}.
Interaction partners:
- WD_REPEATS_REGION domain-containing protein
- WD_REPEATS_REGION domain-containing protein
- Probable ubiquitin carboxyl-terminal hydrolase K02C4.3
Sequence:
MNTADVPDNLQSWGQQPSSSYSNTQQHSQMTNLPPINHNNLCDTEPMNEDFQLQDVQADELQKQQKQQEQQHIQQQNAQRFIAQSRQPHSNILRFPQPPITSIKTNSHAFYPQQEVTQVRPKKHRVSMTNAEAALTPGMPPEKQAAKKRNIGQFSTDTVPAGIGMIGIPFESTSKPLQIQQFRNPQDAPVRKLTSDLIKTYKAINESFYLRKQVRRDRHKSQDAGKPKGSKDGSGASLTDTFSIHNAIPITSSDNHYQQDAHQNAPPLLDTNAPPTSTMVVPMRTETDLQQQQRQKSSRGGPYNNGYDDQNYDYILKNGEIFDKRYVILSDTPVGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQIEIHLLELTNAHDKDNKYNIVTLKGHFVHRAHLCLVFELLSYNLYDLLKNTSFRGVSLNLARKFAQQLGKTLLFLSSPELSIIHCDLKPENVLLVNAKRSQIRVIDFGSSCQTGHRIYQYIQSRFYRSPEVLLGIAYDTKIDMWSLGCILVEMHTGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDIGPKTHKYFDKTEDGIYYCKKTRDGYRHTYKAPGARKLHEILGVTSGGPGGRRLGEPGHSVEDYSKFKDLIKRMLQFDPKQRISPYYVVRHPFLKQKEERVPSQPPVSHSNLQQQQQLYIQQPSSQMSQVMESPSVGSVYVEDNGMYRQAPGSSANPISVTSSFDEGDAMEVDAGRRRFSAHQQNYHNPNYQYSQPQQQQQQQYQQTQRTQLEQQQKQAQLQQQLQQQQMQQQQQQQQQRQHMPQAQSSSQQHLQSRARPRQQDQNEWRNQFELDDTFQQKQRKVDDSVSNQISRNQFNPQQVSMTHGNVNANNREMEKLDYPNNKL
Protein: Vacuolar protein sorting-associated protein 9b (Vacuolar protein-targeting protein 9b) (O94388)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- GTP-binding protein ypt5
- Translation initiation factor eIF2B subunit beta
- GTP-binding protein ryh1
- Vacuolar protein sorting-associated protein vps901
- Vacuolar protein sorting-associated protein 29
- Uncharacterized carboxypeptidase C24C9.08
Sequence:
MSFLNSWRAVKYTNKPKEEDIKLPNSASNLPTTVQACVIQFISSLVSPVHPQLLSPEELAKAFQNFYKHTDEFIASTLIPQPSSKDQNVPLLFPEEIDAQKKARQHLLNQKDEWMDQIEDIVCEYLYDRIFCLSTSTDAAKDDLLKKFIASEEKKELINCIPIPDDEKLTNRLHEVSEAFFALDEQHTPRSKINTFMTVNSSILNASQLPQEELNADSLLNLTIYCILCYPGFHLISHLNFVLRFRNADFLSGEQRYCLTTFEAALTFILRACPNLLTQSSIQPSDDPLSLEVANSETVSTSNSLHDPSAEPYPVNRSSLSNLRNLGLALEKSYASLLSKVANHTAKSSEDSSNSVEFVGDPPLERFLTVSDASDLKIGEIELLLSDYKRLARLLFEKNGNQ
Protein: Transporter, putative (Q387W5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MAIWACIARSGLVVSKIIACSGLSYFISHFFSWTEKSVGGFADVSLMIFLPSLTFVSITKFENAERAYMFLWAAIFACVPRILALASATLLRCAYPTRWHGLVMLSCVLQNSFTFGLGTLFMLKGIPWFTNEVGEEAIAFFLCYSTVNFLVCWLTAELIVRPYAKAPVAVLSACAQEKAEGCEREMSCREEENRCGIVKDTATSDNRLRTTRETGATPPLYAPKGEPTRVSANEAGEQCAPTSGGGSDDVIHNSASSSCFSVKTLKLVLGVIRKPLIVTTVIAIIVSMTPIRRVLHVPVLGTTLVGGMKLVAYGTLPLHFLLLGYEAGRTWKVHATTASERADAAQGDSRDGHGEVSGWETSAGRRDSDDTQIKTFVLAFALAFNAHVVVPLLCFLIILAFKTYDLIPTSKSFLLAIFVGSCAPSAIDPFLICSNNALLPLAYSKIMHVMVLSGGLTTFAWLSVYLCVLEE
Protein: Solute carrier family 25 member 45 (Q8CFJ7)
Organism: Mus musculus (Mouse)
Subcellular location: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
Sequence:
MPVEEFVAGWISGAVGLVLGHPFDTVKVRLQTQSTYQGIVDCVVKTYRHESVLGFFKGMSFPIASVALVNSVLFGVYSNTLLALTATSHQERRAQPPSYTNIFIAGCTGGLLQAYCLAPFDLIKVRLQNQTEPRMQISSSMPRYRGPVHCAASILREEGPQGLFRGSWALVLRDTPTLGMYFVTYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWITATPFDVIKSRMQMDGLKGRKYGGMLDCMASSFRQEGIGVFFKGMTLNSARAFPVNAATFLSYEYLLRLWR
Protein: Erythropoietin receptor (EPO-R) (EpoR) (xlEPOR) (Q4W815)
Organism: Xenopus laevis (African clawed frog)
Function: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16091591}; Single-pass type I membrane protein {ECO:0000269|PubMed:16091591}.
Interaction partners:
Sequence:
MGAPSSLLFSTAHWRTVPFLLAFWVLLSTGTAEDPTMTPEFLRHISEKIPEEYQNPHCFTRDLNDFICFWEGERRKNASFSYSEDDQIKWCQLRTEVASNNTWWYICEFPVTDVVLFAGITISAYPCHKCQTAREIYINELVLLNPPLNVTVKEKQDPRGLLISWKPPHFQKNHDINNEIKYQVNYSTPGADMQTVEVEAGNTEIFLTDIVPAAYTVTVRCKADGVSYNGYWSDWTAPITIATIIDLRLLLLLSIAIFVALIAGVGVYIFMRHGMYLKHKVWPQVPTPENNFQGLFTTHKGNFKLWLGQADAYLLWISRHVFQEDPSSTLEVLSELPPAALPQSFNPNPLKDSYVVLDENRMPCSLEWLEAQRHKTVIVGAESMDSRLQTVNKDVVLEDTSKGQIAVKANNRVHSLEGDGSQGEAFREDEYVEAPRMEHERHRVSRENSVSSDGKQSIPSSFEYTELQTCEGLLSPKPRPVPPRMPLKYAYLDMSSSGEHSPPPSPNFYQNSPITNFLAPIYSQS
Protein: NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) (Q7ZVK3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter. Thereby contributes to regulate expression of vegfa, a key regulator of angiogenesis. In addition to protein deacetylase activity, also has activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8IXJ6}. Nucleus {ECO:0000250|UniProtKB:Q8IXJ6}.
Interaction partners:
- Nicotinamide phosphoribosyltransferase
- Nicotinamide phosphoribosyltransferase
- Glutamine-dependent NAD
- Nudix-type motif 12.
- Ectonucleotide pyrophosphatase/phosphodiesterase 1
- NAD
- Uncharacterized protein.
- Uncharacterized protein LOC393330
- Nicotinamide nucleotide transhydrogenase 2.
- Protein deacetylase HDAC6
Sequence:
MSEEVSKRVEEEADTPGLEGQSDDSSDEGDASGDTEMDFLRSLFSRTLGLSPGDKVLDELTLDSVARYILSGKCKNIICMVGAGISTSAGIPDFRSPGTGLYANLQKYNLPYPEAIFQIDYFKKHPEPFFALARELYPGQFKPTVYHYFIKMLKDKGLLRRCYSQNIDTLERVAGLEGEDLIEAHGTFHTSHCVSFLCRKEYSMDWMKNQIFSEEIPKCDSCGSLVKPDIVFFGESLPSRFFTSMKADFPQCDLLIIMGTSLQVQPFASLVSRVSNRCPRLLINMEKTGQSEFGMGLFSFGGGMDFDSDKAYRDVAHLSTCDDGCMTLAELLGWKKELEEMVKREHALIDSKDAKKTDKEASQSSKSAVAEAEKTDKTE
Protein: Fibroblast growth factor 13 (FGF-13) (Fibroblast growth factor homologous factor 2) (FHF-2) (P70377)
Organism: Mus musculus (Mouse)
Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. Regulates voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons.
Subcellular location: Cell projection, filopodium {ECO:0000269|PubMed:22726441}. Cell projection, growth cone {ECO:0000269|PubMed:22726441}. Cell projection, dendrite {ECO:0000269|PubMed:22726441}. Cell membrane, sarcolemma {ECO:0000269|PubMed:21817159}. Cytoplasm {ECO:0000269|PubMed:22726441}. Note=Not secreted. Localizes to the lateral membrane and intercalated disks of myocytes. {ECO:0000269|PubMed:22726441}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q92913}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q92913}. Nucleus {ECO:0000250|UniProtKB:Q92913}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:10644718}. Nucleus {ECO:0000269|PubMed:10644718}.
Interaction partners:
- Sodium channel protein type 5 subunit alpha
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 3
- Calmodulin-1
- Sodium channel protein type 3 subunit alpha
- Fibroblast growth factor receptor 1
- Sodium channel protein type 1 subunit alpha
- Sodium channel protein type 8 subunit alpha
- Fibroblast growth factor receptor 4
Sequence:
MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSEHFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST
Protein: Tryptophan biosynthesis protein TrpCF [Includes: Indole-3-glycerol phosphate synthase (IGPS) (EC 4.1.1.48); N-(5'-phospho-ribosyl)anthranilate isomerase (PRAI) (EC 5.3.1.24)] (P00909)
Organism: Escherichia coli (strain K12)
Function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
Interaction partners:
- Anthranilate synthase component 1
- Tryptophan synthase alpha chain
- Bifunctional protein TrpGD
- Tryptophan synthase beta chain
- Aminodeoxychorismate synthase component 2
- Aminodeoxychorismate synthase component 1
- Bifunctional chorismate mutase/prephenate dehydratase
- 1-
- Histidine biosynthesis bifunctional protein HisIE
- Divalent-cation tolerance protein CutA
Sequence:
MMQTVLAKIVADKAIWVEARKQQQPLASFQNEVQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIAAIYKHYASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSALMAHDDLHAAVRRVLLGENKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADVVDKAKVLSLAAVQLHGNEEQLYIDTLREALPAHVAIWKALSVGETLPAREFQHVDKYVLDNGQGGSGQRFDWSLLNGQSLGNVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY
Protein: Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) (Q15084)
Organism: Homo sapiens (Human)
Function: May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15466936}. Cell membrane {ECO:0000269|PubMed:15466936}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12643545}.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
- Endoplasmin
- Peroxiredoxin-4
- ERO1-like protein alpha
- DnaJ homolog subfamily B member 11
- ERO1-like protein beta
- DnaJ homolog subfamily C member 3
- Hypoxia up-regulated protein 1
- Calreticulin
- Protein disulfide-isomerase A3
Sequence:
MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDDLGKDEL
Protein: At1g73390 (Endosomal targeting BRO1-like domain-containing protein) (Q9FX34)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Non-phototropic hypocotyl-like protein
- Endosomal targeting BRO1-like domain-containing protein
- Cation/H
- SAGA-associated factor 29 homolog B
- Protein disulfide-isomerase 5-3
- Homeobox-leucine zipper protein HAT1
- Pumilio homolog 3
- Cinnamoyl-CoA reductase-like protein
- Cation/calcium exchanger 3
- Serine protease SPPA, chloroplastic
Sequence:
MGCFASRPNDTGGNRRKPTSIGDVSVYVPGLRIPKPVEFSQSLGDQLPKTLVERLTALRTRIVVMANQEGPTITRTRRKTQHGGSTLADLHHALEDYIPVLLGLTKDGSHLQFKVQFNWVNQEDEEEETAMSNVWYEILSVLHLMAMLQMSQANLLLLPRGSSDGYHPKISEENRRASIDIFLKAAGYLDCAVKHVLPHFSTEQRRSLPIDLAEGALRALCLQALGQGVDIQLGMAIDSAKATLAVKRRLSCEMVKYWQQAQDNLMNLPLANGWGEKHMLFVKWKYVEAKAAAYYYHGLILDEGNTEKSHGMAVAALQAADECLKESKKASEAFNTSSPTSRTPSLFGTMKYLSEKIPKETSSKVRINRDLYSYEKIMETAPTLPDFALALKPDEYQLPSVDASWSEASLRTKNTSNHI
Protein: Pectin lyase-like superfamily protein (Putative polygalacturonase) (Q9SUP5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable pectate lyase 22
- Probable pectate lyase 20
- Probable pectinesterase/pectinesterase inhibitor 54
- Protein STRICTOSIDINE SYNTHASE-LIKE 9
- Probable pectinesterase/pectinesterase inhibitor 32
- Protein STRICTOSIDINE SYNTHASE-LIKE 4
- Probable pectate lyase 8
- Protein trichome birefringence-like 38
- Probable pectinesterase/pectinesterase inhibitor 16
Sequence:
MWRLSVSIFLFSCLFVSSSSLGDSEATCSGIVPLRYRYDKISITDFGGVGDGRTVNTKAFRAAIYRIQHLKRRGGTLLYIPPGVYLTESFNLTSHMTLYLAKGAVIRAVQDTWNWPLIDPLPSYGRGRELPGGRYMSFIHGDGLRDVVITGQNGTIDGQGEVWWNMWRSRTLKYTRPNLIEFKDSKEIIISNVIFQNSPFWNIHPVYCSNVVIHHVTILAPQDSPNTDGIDPDSSYNVCIEDSYISTGDDLVAIKSGWDQYGIAYGRPSSNITIRRITGSSPFAGIAIGSETSGGIKNIIAEHITLSNMGVGVNIKTNIGRGGYIKNIKISDVYVDTAKYGIKIAGDTGDHPDENYNPNALPVVKGIHIKNVWGVNVRNAGSIQGLKGSPFTGICLSEINLHGSLNSYKTWKCSDVSGTSLKVSPWPCSELRTTGGSNLCSSTF
Protein: Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1) (Q9JIF3)
Organism: Mus musculus (Mouse)
Function: Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10860996}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JJZ1}; Multi-pass membrane protein {ECO:0000255}. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250|UniProtKB:Q9JJZ1}.
Interaction partners:
- AP-2 complex subunit beta
Sequence:
MSPEDPQETQPLLRPPEARTPRGRRVFLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLALLRRPGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRRLLLALSGVIMVFSMSAFGTYFKLTQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVMEMLRPYGAFWLTAAFCALSVLFTLTVVPETKGRTLEQVTAHFEGR
Protein: Gastricsin (EC 3.4.23.3) (Pepsinogen C) (P20142)
Organism: Homo sapiens (Human)
Function: Hydrolyzes a variety of proteins.
Subcellular location: Secreted.
Interaction partners:
- Phosphoglucomutase-1
- 6-phosphogluconate dehydrogenase, decarboxylating
- Cytosolic non-specific dipeptidase
- Vacuolar protein sorting-associated protein 18 homolog
Sequence:
MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA