wanglab/gogpt-training-data huggingface dataset:
Protein: GDSL-family esterase (B2ZAB3)
Organism: Geobacillus thermodenitrificans
Interaction partners:
Sequence:
MRRNIVSLLMMVAALSALLWLGGLALVVQDQLFTAAKPSIEQKRPSANEAKKRDGEIDIVALGDSLTRGTGDESGKGYIGYMVDELRQQTDEPIRVTNLAIRGLRSDGLLRQLGQSEIQRQIAMADLIVMTIGGNDLFQGGEALEWNVKELDEAKRQYIANLDRIFALLRRLNSEAVIFAIGLYNPFSDLDDAKRTSAIVRDWNFASAEVAAHYPNIVAVPTFDLFALHVNDYLYSDHFHPNKEGYKRIGERVASLITLTEEDRQ
Protein: Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4] (P01019)
Organism: Homo sapiens (Human)
Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Subcellular location: Secreted {ECO:0000305|PubMed:4300938, ECO:0000305|PubMed:7259779, ECO:0000305|PubMed:7539791}.
Interaction partners:
- Type-2 angiotensin II receptor
- Renin
- Angiotensin-converting enzyme
- Type-1 angiotensin II receptor
- Angiotensin-converting enzyme 2
- Protachykinin-1
- Kininogen-1
- Gastrin-releasing peptide
- B2 bradykinin receptor
- Endothelin-1 receptor
Sequence:
MAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA
Protein: Sulfotransferase 3, isoform C (EC 2.8.2.-) (A0A0B4KF40)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNRVQVTPRSYPTNLIDKDWGNRKLFYTKDSENFLRLVHDMKLRDDDVWIVTLPKCGTTWMQELLWLLLNNCDFEGALAKDQELRTPFLEFGYSVFHDPNRSFGPIEDLKSPRLIKSHLSLALLPSKLWEGKNKVIYVSRNPLDSYVSRYYHGVSFGFNYGKSLHQYFDEVLASDDFPTEFIEHAHEFYQLRNEPWVFYTSFEMMKKDLRGVINDVSRFLNKPINDQQMEKLLKHLSFAEMKKNPTTNHLWELAQVQHENAGKEMHPFVRRGDVNGYKDELKPEQIEKANVRIQEVLAKNGVTLDELLLLKDQDWPCSGLCTQHSQTNSEAITLRNGPKAHQHQCSSACTRWLCVRVKVVKAESRGRTGPILMLMQGSRDAEMPTPPPQREAKNGKQATFIAGREVFTVLWERRISQDVNRGSCTMFAPHSLPVTSRLLLLVVTLLFCPVQAHLSKRSYSDQSVHGYMTERTCWWNEVCKEEFQSLFRCKCPQFSYCRSPGRYYNAYCSMTDTGYIWTQPNWDWGA
Protein: General transcription factor IIF subunit 2 (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) (Q01750)
Organism: Rattus norvegicus (Rat)
Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Subcellular location: Nucleus.
Interaction partners:
- General transcription factor IIF subunit 1
- Transcription initiation factor IIE subunit beta
- Transcription initiation factor IIB
- TATA box binding protein
- DNA-directed RNA polymerase subunit beta
- Transcription initiation factor IIA subunit 2
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- General transcription factor IIE subunit 1
- DNA-directed RNA polymerase II subunit RPB3
Sequence:
MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKAPGRGEVGKLRIAKNQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMKLKRLQIEESSKPVRLSQQADKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVGYLKEILKEIGIQNVKGIHKNTWELKPEYRHYQTEEKSD
Protein: LexA repressor 2 (EC 3.4.21.88) (P59479)
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Interaction partners:
- DNA linked enzyme involved in DNA repair
- Translesion DNA synthesis-associated protein ImuA
- Error-prone DNA polymerase
- Protein RecA
- DNA polymerase IV
- Probable HTH-type transcriptional regulator TtgR
Sequence:
MDTLTPKRRAIFEFIRERIAEHGQPPSLADIATRFGFASRSVARKHITALCQAGYIDVTPNQARGIRLAEPLRRPEILEIPVLGQVAAGAPIGPDLGIHEQLLLDPSLFRRTPDYLLKVRGDSMIDDGIFDGDLVGILQQADARDGQIVVARLDGEVTIKRLQRQGGTYRLLPRNPAYAPIDVQPEQDFFIEGVFCGLLRRD
Protein: TPM domain-containing protein (Q57ZB7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MERTRINFSPLRVSSSPARRILSDIVFFSGGRGGSAVFRPVLLMAQRSAGVNLLSPLAKLGQSRDLAADIKAGRHRNNKEVIASFEKIQTFDEIHYRKSDRPWELVPRYAKKRVSDLCGLLSSEDRMEIEQAIDKMQSLCEVDMYVVLVPTVGYTTPRAFANSILFDWGIGEPRGNGLLLLIAQSEASVQLVTSPAIEEYFAEHFLQAAVKEIFQPLVREGKASYAVVQLVYAIARQAQEMHTLWNRGFLALPTRNKVRFAAKTAAYGVTSVPYLLIGIIFFGLCSTVLVNQIIDTMCPTCYGSMHRVRDDATLQSIMTRGQYLEFSNGCAHYRVWKCPRCADSSRVTLTSRDLHQSTRCLQCMDCNYYTCTLTKEVQKLPTKEEDGLKQLLYTCENCRIGREVLLPLLRPIDTTSEANWYDFLIDRASTHKKTGIKL
Protein: Ext1 protein (Q3B8R0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648}.
Interaction partners:
Sequence:
HLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVLLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVIVIEGESKVMSSRFLPYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIERL
Protein: Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171) (Q99592)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.
Subcellular location: Nucleus. Note=Associates with condensed chromatin.
Interaction partners:
- Translin
- DNA
- C-terminal-binding protein 2
- C-terminal-binding protein 1
- DNA-binding protein inhibitor ID-2
Sequence:
MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK
Protein: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Q8IH64)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU361143}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115, ECO:0000256|RuleBase:RU361143}.
Interaction partners:
Sequence:
KSVPFKRNEPVKGEQSFTFTFPRAAAKQTFIVETVASKGIRPHPEEIRQNDKQFVKYTGNLHLYSKYRTNSQKTNVKLSSSNILSHTQVKPFSVSSNKITLGPYENVEAFSQEPLVIHYENSAPFVTVNTLERTLEISHWGNIAVQESIQMTHTGAKLKGSFSRYDFQKEGRSGLAALKSYKTYLPASASGVYYRDTNGNISTSNMNAVRDFIELELRPRFPLFGGWKTQYTLGYNVPSYEYMFNDGNKYQLKMHLIDHIYDNMAIDEATIKIILPEGSSDIRLSTPYSISRLPNELVHTYLDTIGRPVVSFSKSNLVESHISDFTLHYSFSKTSMLQEPLLVSGFIYIIFLFTIVFLRLDFSITSHAHKE
Protein: Calcium load-activated calcium channel (CLAC channel) (GEL complex subunit TMCO1) (Transmembrane and coiled-coil domain-containing protein 1) (Q6DGW9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity). Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UM00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UM00}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9UM00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UM00}. Note=The first transmembrane region is required for localization to the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9UM00}.
Interaction partners:
- PAT complex subunit CCDC47
- BOS complex subunit TMEM147
- BOS complex subunit ncln
- Phenylalanyl-tRNA synthetase subunit beta.
- Growth arrest-specific 7
- Protein transport protein Sec61 subunit gamma
- Zgc:109965.
- ER membrane protein complex subunit 6
- Protein transport protein Sec61 subunit beta
- RAB5-interacting factor
Sequence:
MSTMFADTILIVFISICTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITESAGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFVPLSYIQGLSHRNLLGEDYTDCSFIFLYILCTMSIRQNIQKMLGLAPSRAATKQAGGFLGPPPQAAKFS
Protein: Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) (P27550)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
Interaction partners:
- Inner membrane protein YjcH
- Phosphate acetyltransferase
- Acetate kinase
- Citrate synthase
- Fatty acid oxidation complex subunit alpha
- Cation/acetate symporter ActP
- Phosphate acetyltransferase EutD
- Malate synthase A
- Pyruvate dehydrogenase
- Malate synthase G
Sequence:
MSQIHKHTIPANIADRCLINPQQYEAMYQQSINVPDTFWGEQGKILDWIKPYQKVKNTSFAPGNVSIKWYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDASQSKHISYKELHRDVCRFANTLLELGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSNSRLVITSDEGVRAGRSIPLKKNVDDALKNPNVTSVEHVVVLKRTGGKIDWQEGRDLWWHDLVEQASDQHQAEEMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPLACGATTLMFEGVPNWPTPARMAQVVDKHQVNILYTAPTAIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGNEKCPVVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNEGNPLEGATEGSLVITDSWPGQARTLFGDHERFEQTYFSTFKNMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHNIKGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPGVVEKLLEEKQAIAMPS
Protein: RNA polymerase sigma factor SigA (Sigma-A) (P9WGI1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth (Probable).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00963}.
Interaction partners:
- DNA-directed RNA polymerase subunit omega
- DNA-directed RNA polymerase subunit beta
- Probable transcriptional regulator WhiB7
- Transcriptional regulator WhiB1
- DNA-directed RNA polymerase subunit beta'
- DNA-directed RNA polymerase subunit alpha
- RNA polymerase-binding protein RbpA
- RNA polymerase-binding transcription factor CarD
- Conserved protein
- Protein PafC
Sequence:
MAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSPPAKRATKPAARSVKPASAPQDTTTSTIPKRKTRAAAKSAAAKAPSARGHATKPRAPKDAQHEAATDPEDALDSVEELDAEPDLDVEPGEDLDLDAADLNLDDLEDDVAPDADDDLDSGDDEDHEDLEAEAAVAPGQTADDDEEIAEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
Protein: BRCT domain-containing protein (Q580Y8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Cell division cycle 45
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM3
- Phosphatidylinositol 3-kinase catalytic subunit, putative
- non-specific serine/threonine protein kinase
- FHA domain-containing protein
- RNA-binding protein, putative
- Protein kinase, putative
- Proteasome regulatory non-ATP-ase subunit 5
- Replication factor C, subunit 2, putative
Sequence:
MGDNPLSVLQQLASNPQLITQMQGILALLSPGHGDGATGARPGGVGLEQIAALCPQPRTLQNTATTDMGAASSLMAGGLNVEPPRQQTRWPSPVATASESSNLQSRGDSKSDVGKYGVVSVERYERLMARYKELEKQSHRRQGKRSEPVVDTQRVLDLEEEVARLKRTIGHLQGVVEEKESALEKHATQHNLEVHEMKKNYELKIKSLTQTHEAAVRKLVSAQELVTAARNYQTAVCANNVGGGNSVSTTSGQPLSNTVNHTRGLTTTSSGSGPNQPYTLPHPDGNAWMSATTSDDRSAPVTTKNSHSVKREREGTVSTTPTRPLKKRNPRTPSYTVADRISETDEYVKKGSPVVKKELNSPTAEAQQTCLDGMGYQPAVGSNILRAQTSYTSAACTLVEAVSNSRQQFQQQRSESVQMQPRSGAVALRQRTGGLSPVASSSGSALMATPSSRGLRRPFRPVSGASSAVGGSTRSPSPVDPKRGAVQPRYFITTSLTEKERNSVMEAIQKLGQRAVLVDNKVDEILPLNTTHIVLRGPPRSVKALCGVVSSKWLVQPSYVFDSLGAGFWLDEEVEGGLRYFPPPLRCQRFLLTMPEGVVKTMLQRVVEFGGGEVVGTKRNGSSNDQDVVVVSSGDELLRFAISRD
Protein: Glycophorin-binding protein 130 (GBP130 protein) (Q8I6U8)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Involved in merozoite invasion of host erythrocytes.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P02895}. Cell surface {ECO:0000250|UniProtKB:P02895}. Host cytoplasm {ECO:0000269|PubMed:15591202}. Note=Secreted at the schizont stage into the host erythrocyte cytoplasm. Localizes to the cell surface of free merozoites to some extent. {ECO:0000250|UniProtKB:P02895}.
Interaction partners:
Sequence:
MRLSKVSDIKSTGVSNYKNFNSKNSSKYSLMEVSKKNEKKNSLGAFHSKKILLIFGIIYVVLLNAYICGDKYEKAVDYGFRESRILAEGEDTCARKEKTTLRKSKQKTSTRTVATQTKKDEENKSVVTEEQKVESDSEKQKRTKKVVKKQINIGDTENQKEGKNVKKVIKKEKKKEESGKPEENKHANEASKKQEPKASKVSQKPSTSTRSNNEVKIRAASNQETLTSADPEGQIMREYAADPEYRKHLEIFYKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYASDPEYRKHLEIFYKILTNTDPNDDVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERRNADNKELTSSDPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEIFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEIFYKILTNTDPNDEVERRNADNKEELTSSDPEGQIMREYAADPEYRKHLEIFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEIFYKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYASDPEYRKHLEIFYKILTNTDPNDDVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERQNADNNEA
Protein: Zinc finger protein 385A (Hematopoietic zinc finger protein) (Q8VD12)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16286649}. Nucleus, nucleolus {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:16286649}. Note=Detected in dendrites of Purkinje cells and hippocampal neurons.
Interaction partners:
- Cellular tumor antigen p53
Sequence:
MILGSLSRAGPLPLLRQPPIMQPPMDLKQILPFPLEPAPTLGLFSNYSTMDPVQKAVLSHTFGGPLLKTKRPVISCNVCQIRFNSQSQAEAHYKGNRHARRVKGIEAAKTRGREPSVRESGDPAPAGSIPPSGDGVAPRPVSMENGLGPAPGSPEKQPGSPSPPSVPESGQGVTKGEGGTSVPASLPGGSKEEEEKAKRLLYCALCKVAVNSLSQLEAHNKGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNSEVQLKQHISSRRHRDGVAGKPNPLLSRHKKPRGAAELAGTLTFSKELPKSLAGGLLPSPLAVAAVMAAAAGSPLSLRPAPAAPLLQGPPITHPLLHPAPGPIRTAHGPILFSPY
Protein: AQuaPorin or aquaglyceroporin related (Q18469)
Organism: Caenorhabditis elegans
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Aquaporin-3
- Aquaporin-9
- Aquaporin
Sequence:
MTLPQQNNAVPVGQRRKSFISSIQGAMSMNSQKTSTVRPYNLISRCYAEFLGTFIFIFSGTMQANVYDISQPVGLTHAALTHGLATIVVIAVFGKISGGHFNPVVSWAMVLCQKLHPFELPFYMFSQFFGGFAGNLLSACLQRKRDFLNWEDYSSIRYPLPTASIEYGYDKVHNSTLEKTILLTTQLAATTSGITHLGENHEWWEGLISETITTYFFVTVILMNVVNNEPSEATPFIIGMMVIVNIFATASITGTAMNPVRALSPNIVGEIVLSSSSLPPNFWTYHYIYWAGPYLGSTIAVIGFKLLLSKTDRLIP
Protein: Envelope glycoprotein I (gI) (Glycoprotein IV) (GPIV) (Q77NN4)
Organism: Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
Function: In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips (By similarity).
Subcellular location: Virion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Host cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Host cell junction {ECO:0000250}. Host Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). The heterodimer gE/gI then redistribute to cell junctions to promote cell-cell spread later in the infection (By similarity). {ECO:0000250}.
Interaction partners:
Sequence:
MFLIQCLISAVIFYIQVTNALIFKGDHVSLQVNSSLTSILIPMQNDNYTEIKGQLVFIGEQLPTGTNYSGTLELLYADTVAFCFRSVQVIRYDGCPRIRTSAFISCRYKHSWHYGNSTDRISTEPDAGVMLKITKPGINDAGVYVLLVRLDHSRSTDGFILGVNVYTAGSHHNIHGVIYTSPSLQNGYSTRALFQQARLCDLPATPKGSGTSLFQHMLDLRAGKSLEDNPWLHEDVVTTETKSVVKEGIENHVYPTDMSTLPEKSLNDPPENLLIIIPIVASVMILTAMVIVIVISVKRRRIKKHPIYRPNTKTRRGIQNATPESDVMLEAAIAQLATIREESPPHSVVNPFVK
Protein: Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1) (P15337)
Organism: Rattus norvegicus (Rat)
Function: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity).
Subcellular location: Nucleus.
Interaction partners:
- Histone lysine acetyltransferase CREBBP
- CREB-regulated transcription coactivator 2
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Mitogen-activated protein kinase 3
- cAMP-dependent protein kinase catalytic subunit beta
- Cellular tumor antigen p53
- cAMP-dependent protein kinase catalytic subunit alpha
- histone acetyltransferase
- Cyclic AMP-dependent transcription factor ATF-2
- Transcription factor Jun
Sequence:
MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Protein: Cation/H(+) antiporter 15 (Protein CATION/H+ EXCHANGER 15) (AtCHX15) (Q9SIT5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May operate as a cation/H(+) antiporter.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Interaction partners:
- F-actin-capping protein subunit alpha
- Protein RALF-like 4
- Armadillo repeat only 1
Sequence:
MATSEEPSTDASIICYAPSMITTNGVWQGDNPLDFSLPLFVLQLTLVVVVTRFFVFILKPFRQPRVISEILGGIVLGPSVLGRSTKFAHTIFPQRSVMVLETMANVGLLYFLFLVGVEMDIMVVRKTGKRALTIAIGGMVLPFLIGAAFSFSMHRSEDHLGQGTYILFLGVALSVTAFPVLARILAELKLINTEIGRISMSAALVNDMFAWILLALAIALAESDKTSFASLWVMISSAVFIAVCVFVVRPGIAWIIRKTPEGENFSEFHICLILTGVMISGFITDAIGTHSVFGAFVFGLVIPNGPLGLTLIEKLEDFVSGLLLPLFFAISGLKTNIAAIQGPATWLTLFLVIFLACAGKVIGTVIVAFFHGMPVREGITLGLLLNTKGLVEMIVLNVGKDQKVLDDETFATMVLVALVMTGVITPIVTILYKPVKKSVSYKRRTIQQTKPDSELRVLVCVHTPRNVPTIINLLEASHPTKRSPICIYVLHLVELTGRASAMLIVHNTRKSGRPALNRTQAQSDHIINAFENYEQHAAFVAVQPLTAISPYSTMHEDVCSLAEDKRVSFIIIPFHKQQTVDGGMESTNPAYRLVNQNLLENSPCSVGILVDRGLNGATRLNSNTVSLQVAVLFFGGPDDREALAYAWRMAQHPGITLTVLRFIHDEDEADTASTRATNDSDLKIPKMDHRKQRQLDDDYINLFRAENAEYESIVYIEKLVSNGEETVAAVRSMDSSHDLFIVGRGEGMSSPLTAGLTDWSECPELGAIGDLLASSDFAATVSVLVVQQYVGSWAQEDDMDFPESPVHSHETKVTYGLENPR
Protein: Kinesin-like protein (G5EC43)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Interaction partners:
Sequence:
MSSRKRGITPSRDQVRRKKLSIEETDSIEVVCRLCPYTGSTPSLIAIDEGSIQTVLPPAQFRRENAPQVEKVFRFGRVFSENDGQATVFERTSVDLILNLLKGQNSLLFTYGVTGSGKTYTMTGKPTETGTGLLPRTLDVIFNSINNRVEKCIFYPSALNTFEIRATLDAHLKRHQMAADRLSTSREITDRYCEAIKLSGYNDDMVCSVFVTYVEIYNNYCYDLLEDARNGVLTKREIRHDRQQQMYVDGAKDVEVSSSEEALEVFCLGEERRRVSSTLLNKDSSRSHSVFTIKLVMAPRAYETKSVYPTMDSSQIIVSQLCLVDLAGSERAKRTQNVGERLAEANSINQSLMTLRQCIEVLRRNQKSSSQNLEQVPYRQSKLTHLFKNYLEGNGKIRMVICVNPKPDDYDENMSALAFAEESQTIEVKKQVERMPSERIPHSFFTQWNSELDGSVRMEDDGSREIPCPPTFCLTDCNDKDTVDSMYKYARKLSSLQNSSEEGPSSTLLTMIRQYMMEADYQRVEIARLKDSLNDKDEEIKKLRGFCSRYKRENASMKERIASCEQGEQENALVMEKLMEQKMEDRKIIQSQKKAMRNVRGIIDNPSPSVASLRSRFDQENVAHPTAPIQTPPPPYQTPGRAPVFKKRLEATTSTTVMSGSSSGGSGQQGYVNPKYQRRSKSASRLLDHQPLHRVPTGTVLQSRTPANAIRTTKPEMHQLNKSGEYRLTHQEVDDEGNISTNIVKVNSLVSTQKHACTVPLSFSRVLITHLS