wanglab/gogpt-training-data huggingface dataset:
Protein: GRB2-associated binding protein 1 (C6JUQ2)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEDMNKWVRCICDICGFNPTEEDPVRPLASSSQAPADSPFAINTAPASAHMEPSSVALPPSYQLISLPPHPDTLGLREDPQDYLLLINCQSKKPEPTSQGSSLVSEEGEEYLLLEDFESKAIPLQAHFDSAKPTSSETDCNDNVPSHKPPASSQGKHGMNGFFQQQMVYDCPPPRVTSVSGESGLYNLPRSYSHDVLPKESPSSTEADGELYVFNTPSGTSSVEAQMRHVSISYDIPPTPGNTYQVPRTFPEGTLGQSSKLDTIPDVPPPRPPKPHSTHDRSPVETCGVPRTASDTDSSYCIPPAGMPPSRSNTISTVDLNKLRKDAGSQDCYDIPRTFPSDRSSSLEGFHNQLKIKNVLAAGNVSGEELDENYVPMNPNSPPRHHPSSFAEPIQEPNYVPMTPGTFDFSAFGMQVPPPAHLGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLSEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSNEDQNLFCNNSLEGASSPMTKPKGDKQVEYLDLDLESGKSTPPRKQKNSGSGSSMSDERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPTKNVK
Protein: Endo-beta-N-acetylglucosaminidase EndoS2 (EC 3.2.1.96) (Endoglycosidase S2) (T1WGN1)
Organism: Streptococcus pyogenes serotype M49
Function: Endoglucosidase that acts as a host immune evasion factor by mediating hydrolysis of the N-linked glycan from the Fc region of host immunoglobulin-gamma (IgG) during infection. Specifically catalyzes the hydrolysis of the beta-1,4 linkage between the first two N-acetylglucosamine residues of the complex-type N-linked glycan located on 'Asn-297' of the Fc region of IgG antibodies (IGHG1, IGHG2, IGHG3 or IGHG4), thereby preventing interaction between IgGs and Fc receptors and ability to activate the complement pathway (By similarity). Also able to cleave biantennary and sialylated glycans of host alpha-1-acid glycoprotein (ORM1 or ORM2). Acts on N-linked glycans with or without core fucosylation. In contrast to EndoS, also able to process oligomannose- or hybrid-type glycans. Specifically acts on IgGs; does not act on immunoglobulin alpha, beta, delta or mu.
Subcellular location: Secreted {ECO:0000305|PubMed:23865566}. Host extracellular space {ECO:0000250|UniProtKB:Q99Y92}.
Interaction partners:
Sequence:
MDKHLLVKRTLGCVCAATLMGAALATHHDSLNTVKAEEKTVQTGKTDQQVGAKLVQEIREGKRGPLYAGYFRTWHDRASTGIDGKQQHPENTMAEVPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELNGRTGLSKDYPDTPEGNKALAAAIVKAFVTDRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESASKGNLWFDVNEYDPNNPEKGKDIEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVPSTYKNRTSTNLQRHEVDNISHTDYTVSRKLKTLMTEDKRYDVIDQKDIPDPALREQIIQQVGQYKGDLERYNKTLVLTGDKIQNLKGLEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTKEGHYDVDNAEHDILTDFVFGTVTKRNTFIGDEEAFAIYKEGAVDGRQYVSKDYTYEAFRKDYKGYKVHLTASNLGETVTSKVTATTDETYLVDVSDGEKVVHHMKLNIGSGAIMMENLAKGAKVIGTSGDFEQAKKIFDGEKSDRFFTWGQTNWIAFDLGEINLAKEWRLFNAETNTEIKTDSSLNVAKGRLQILKDTTIDLEKMDIKNRKEYLSNDENWTDVAQMDDAKAIFNSKLSNVLSRYWRFCVDGGASSYYPQYTELQILGQRLSNDVANTLKD
Protein: I/6 autoantigen (Q57WF9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Superoxide dismutase
Sequence:
MLCPPDVAFEKRHFKRRDGNKVVPPSIALVAGLESGFLFKLSAVEDVARRGQFPGLLTEDEFLLMCEESEHIRDAYAMAKHLVALAPDGIFTRATLQETAGKVGSTQDTLSVEEVDALFNALDSDNRGYVSVDEFMDALYGEEGREAMREIRREYMRRKIEVEGEPIVEDEANPEADAEAEAEAEARARAEAEAEARAEAEARARAEAEARARAEAEARARAEAEARARAEAQRPPPPKQKAGCGC
Protein: Uncharacterized protein (Q38AV0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSGPGVDLTPVGAVAPAGVVLHSGQQFVTPGANGHVIRNSPYGSKRPLYGWGDLFRPGKTAIVPGWSNIHIGVSSLNAVPGADRRMRTLMTKYQKKFNCLEHCYTFHNVGDEDMWRTWRELALLPMNSGPSSSPAQSPRQRDKGTGVKEKADTPCKYACGEKRRRASQNEVTTADVEASFGYDDDVDSCANCGNQHSPFMYTIKANRYLTHNRLLVMDDATKEHITQFFVQRCTLLEHILGPVLFQLPPHFPKTGEHVARIEAVAACLPKNIRVAVEFRHVSWYAEDTRELLQRLQWAQVVAHNLDVSAGSVHVDTGVPFMYVRMHGPLGRNVGDYGPLILSSWAKRIVEFVRADRDGTDGKVDGAVTPKREVFFFFNNGDSSVGGTTSSVVDATCLAEKVRMLLARQRGAIQGVDYVDVNSSESSCNEDDRRTVKETFIISD
Protein: Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) (Q9VVA9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- RNA helicase
- Non-canonical poly
- Inactive non-canonical poly
- Zinc finger CCHC domain-containing protein 8 homolog
- RRM domain-containing protein
- Exosome complex component 10 homolog
- LD23303p
- FI07225p
- Exosome complex component RRP45
- Csl4
Sequence:
MSDLEEMDSERLNELESILYASIHYSDGFEEHTAMDQPAKESTSDQDARSMPPPPQQKHPIPGQRFVSGTRVINNSMQKPRYWIDGAAAVGEGQVVQAEEQQATTNKTMPAVEESSSSQSMDVDMPQDKSLLLSPEKGTSNQPKTASQPPKHQQIPQAKQQQNIHAKQLQNQQAKPQEQKNSQQKQQQSLKQQNQQSKQHQNQQKKSAPVVQKPKPQPNASTKVNHEAYEAERFDQRLLVAIPPNCPPKKQNKPQQNKQQQQQNKQQQKKQQQSLQHNKQQQQSGPGPFGKANRKLEQIQRLADKKQKSKQAQLNKKQRKQQSPPVEFVNLAETSESSDDDDVVHVPLPPAPIIELDTSDGEQTCTSSQLFHEENAMDATDVKMGLSCITEPEGTSVVASSTTPPMHSPSCSVMSSDDFIVQKDTTRLLTECENANDEDLLVLTETAIREAIGEEPKDKEVVENASEEQEHDHAADTSSEYEFVPPSRLEEIKKNYRVDDQQFRALDVYESESDLTESGIYSKAKSKTTPTIIRNVDSSSGSSSVEEVVEPSVQKTKRLRKRSCSTNNHSQSDPNNDDGLDDSDSDDGVHATGVPGIARGMAVERCKRKIRRISTRHSSDDNSKKAATRIQKPKVAAVHHASSESASEDELPSARDIAERLLNQQQGQGKVQVQKGDGDDDAISIGSDEDSHAEAEFRDAMTDRLAAVFERLDAKAKKMEEDEEQVNASGYISDEEDSRDKSADTTVRSDEDIDASNDLEETNPDKNDRDVTNEEQHVHVEHNLQELRDESLPKSGDLIGWNEEMRSFYNDSWNGENFSVHKVQRMMTGHRHEWRINTADRCPVARPRSHAKCSNCFEMGHVRSKCPRPRKPLVCFICGTMGHAEPRCPNAICFGCGSKQEIYVQQCNKCSFHSRLVCQLCKMRGHGVDHCPDKWRRYHSTTRSNTELDSRVQYRSVQCSYCAGRHSFENCRQRIGDFRSTNYTSQIVSHQKIYKNRGGPIGNLGDLKSFFAIETPFHFKWNNPSMPKNCYYSRFLVNANLAKVQSVKRKSTTAVSQIPEKIYTHEYVPNAQVKAARGEVSTGTAKKPLTKQMPVVESIAENRTAEEPIGKLNREDEKSKDILPLPEVPPEVKQTQDEKLVEGQPNQSQPDEELPMKDDDQEEPSSSVQREEITTNFDNPPTEPGLSRTPLAPHELDSDSNYSFSEHFELPSSTTSDGQPNTQLPLVRTMGTLPDVIPLSKDDFELSSNVQGISMCVNSSSTSLRTDETPDPDSSEELPDVPSEGKIIMAREESEYLFSAEGRTFLAAAAKQCHVSVRMDFKDYGYVLVIYGLKKHQEELQVKLLRRSQEVKRKSIEFQSQKPPKRIDVLIRFLRDGINSLNTNLGNAKSHYVRIKELEGMNTKNGFKMAEKKRRQLNMILVGQAGLLNGKTHLDQLLVLLRRLIDDFSPDEHATPQLRNEIEEHWRMIFSSYPHPNYDSLLNSYGRLDQKNRLPSLHIDPVLLGLQQKKTQSQPQSPSKGPPSPTPLPPVRQDMAPPPPPKMSKKKQRQALDQQTQNQQRQQQQQQQRLQQQHQNQQQRLQQQQKQQQQSLQQQHQQQRVQQQRMQQQQQHQQQDNNQYQQNLRRPQIDQMPYNNLQQRSRSDLQLRHTLNPECDRLLSEMDHNQPGSINKDANKPSMFWSRESLKYLDDLFKMTSNTETVERLKRVLQRSQRGLLSHNDYRAVIRLHSLMCN
Protein: Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) (Q9UJX4)
Organism: Homo sapiens (Human)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Subcellular location: Nucleus {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}.
Interaction partners:
- Anaphase-promoting complex subunit 15
- Fizzy-related protein homolog
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 7
- Anaphase-promoting complex subunit 1
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 4
- Cell division cycle protein 20 homolog
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 13
Sequence:
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRLNQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSRDEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQASLLKNDETKALTPASLQKELNNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEAVNAGVQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARLYHTLGKTQERNRCAMLFRQLHQELPSHGVPLINHL
Protein: Benzaldehyde dehydrogenase YfmT (EC 1.2.1.28) (Vanillin dehydrogenase) (EC 1.2.1.67) (O06478)
Organism: Bacillus subtilis (strain 168)
Function: A benzaldehyde dehydrogenase able to act on substrates with 3- and 4-hydroxy and methoxy substitutions; converts vanillin (4-hydroxy-3-methoxybenzaldehyde) to vanillic acid in vitro. The physiological substrate is unknown.
Interaction partners:
- Putative sensory transducer protein YfmS
- Uncharacterized protein YjfB
- Motility protein B
- Uncharacterized protein YlqB
- Uncharacterized protein YvyC
- Flagellar protein FliT
- Methyl-accepting chemotaxis protein McpB
- Flagellar hook-basal body complex protein FlhP
- Methionyl-tRNA formyltransferase
- Flagellar secretion chaperone FliS
Sequence:
MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATADDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKAAFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLSMKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSFVEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAVFSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQTDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKFDSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGGEKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY
Protein: RNA-binding protein SGN1 (P40561)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: mRNA-binding protein that may play a role in modulating the expression of cytoplasmic mRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10764794}.
Interaction partners:
- Uncharacterized RNA-binding protein YGR250C
- ATP-dependent RNA helicase FAL1
- Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
- Nonsense-mediated mRNA decay protein 2
- SUMO-conjugating enzyme UBC9
- Eukaryotic initiation factor 4F subunit p130
- Eukaryotic initiation factor 4F subunit p150
- Polyadenylate-binding protein, cytoplasmic and nuclear
- Poly
- Pre-mRNA polyadenylation factor FIP1
Sequence:
MSQEEKVDAKATLKTEISNNKKNDKQELELDELVGKLSIEGTPQVSQKLSKEEKHAHQLEADSRSIFVGNITPDVTPEQIEDHFKDCGQIKRITLLYDRNTGTPKGYGYIEFESPAYREKALQLNGGELKGKKIAVSRKRTNIPGFNRHYNSQNQYFQQWQWNYPLMAYPNPDTFPYYPPYPPNQSPNQNFGYNKNNYYRSPYNNKNRTFQKKHFNSAKDSTKNIRSTSQKPVVMPSDNVKSSTQEKDSK
Protein: CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase) (Q8K1J6)
Organism: Mus musculus (Mouse)
Function: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q96Q11}. Cytoplasm {ECO:0000250|UniProtKB:Q96Q11}. Nucleus {ECO:0000250|UniProtKB:Q96Q11}.
Interaction partners:
- Polyribonucleotide nucleotidyltransferase 1, mitochondrial
- Zinc phosphodiesterase ELAC protein 2
- Zinc phosphodiesterase ELAC protein 1
- tRNA dimethylallyltransferase
- Bifunctional glutamate/proline--tRNA ligase
- Tyrosine--tRNA ligase, cytoplasmic
- Biotin--protein ligase
Sequence:
MQSVLYPWHRQVLRCSWSRLCLLKRYLFTMKLQSPEFQSLFTEGLKSLTELFAKENHELRIAGGAVRDLLNGVKPQDVDFATTATPTQMKEMFQSAGIRMINNKGEKHGTITARLHEENFEVTTLRIDVTTDGRHAEVEFTTDWQKDAERRDLTINSMFLGFDGTLFDYFNGYADLKNKKVRFVGHAKQRIQEDYLRILRYFRFYGRIVDRPGDHDHETLEAIAENAKGLAGISGERIWVELKKILTGDHVNHLIHLIYDLGVAPHIGLPANANLEEFNKVSKNVEGFSPKPMTLLASLFKVQDDVTKLDLRLKISKEEKNLGLFIVKNRKDLIKATDSSEPLKPYQDFVIDSREPDATARVCELLKYQGEHGLLKEMQQWSVPPFPVSGHDIRKVGISSGKEIGALLQQLREQWKKSGYRMEKDELLSYIKKT
Protein: Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2) (O95718)
Organism: Homo sapiens (Human)
Function: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1. Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity. During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:18775884}. Cytoplasm {ECO:0000250|UniProtKB:Q61539}. Chromosome {ECO:0000250|UniProtKB:Q61539}.
Interaction partners:
- Homeobox protein NANOG
- Sal-like protein 4
- POU domain, class 5, transcription factor 1
- Nuclear receptor subfamily 0 group B member 1
- Transcription factor SOX-2
- Epidermal growth factor receptor
- Krueppel-like factor 5
- High affinity cationic amino acid transporter 1
- T-box transcription factor TBX3
- Steroid hormone receptor ERR1
Sequence:
MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV
Protein: Transducin/WD40 repeat-like superfamily protein (F4J0P2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- At5g57460
- Calcium-binding EF hand family protein
- Transducin/WD40 repeat-like superfamily protein
- Vesicle-associated protein 4-2
- Calcium-binding EF hand family protein
- RNA binding
- Beta-adaptin-like protein B
- AT5g35440/MOK9_2
- Protein TPLATE
- At1g10020
Sequence:
MEWATVQHLDLRHVGRGVSKPLQPHTAAFHPSQAVIAVAVGSHIMEFDALTGCKIASIDIGSPAVRMLYSPTSSNAVVAILEDCTIRSCDFETEQTCVLHSPEKRSEHISSDTEVHLAVTPLQPVVFFGFPKRMSVTVVGTVEGGRAPTKIKTDLKKPIVNIACHPRLPVLYVAYAEGLIRAYNIHTYAVHYTLQLDNTIKLIGASSFAFHPTLEWIFVGDRRGTLLAWDVSTERPNMIGITQVGSQPITSISWLPMLRVLVTVSKDGSLQVWKTRVIINPNRPSTQTNFFEPAAMESIDIPKILSQQGGEAVYPLPRIKTLEVHPKLNLAALIFANMVGNENTQNRAAQTREGRKQLFAVLQSARGSSASVLKEKLSSMGSSGILAEHQLQALLQEHKGQSQLTISDIARKAFLYSHFMEGHAKTAPISRLPLITVVDTKDQLKDIPVCQPFHLELNFFNKPNRVLHYPVRSFYIEGLNLMAHNLCSGTDNIYKKLYTSIPGNVEYHSKHIVYSRKRHLFLVVFEFSGATNEVVLYWENTGSQLPNSKGSTAKGCDAAFIGPNDDQFAILDEDKTGLSMYILPKLTTMEENEKNLLSEENQKKEADPSGIQGPQQFMFETEVDRVFSTPIESTLMFACNGTQIGLAKLFQGYRLSASDGHYISTQGEGRKSIKLKKHEIALQSFYSLPFNVVYIWPVLFEIKTIMFRKLTRHVQWQETPRGYVAGILTTQRVLMVSLLWVGPALLFSTTTAVCLLGWDGKVRTILSISTPYAALVGALNDRLLLAHPTDISPKQKKGIEIKSCLVGLLEPLLIGFSTMQQTFEQKVDLSEILYQITTRFDSLRITPRSLDILARSAPVCGDLAVSLAQAGPQFNQVLRCAYAIKALRFSTALSVLKDEFLRSRDYPKCPPTSLLFQRFRQLGYACIKYGQFDSAKETFEVIGDYESMLDLFICHLNPSAMRRLAQKLEEESGDPELRRYCERILRVRSTGWTQGIFANFAAESMVPKGPEWGGGNWEIKTPTDMKSIPKWELAGEVMPYMKNEDGTIPSIVADHIGVYLGCVKGRVNVVEIKEDSLVSKPGGLSLLGKPVSDKPLALPAGESSSMMGLESLGKQNVADEQAKAAEEFKKTMYGATGDGSSSDEEGVTKPKKLQIRIREKPTSTTVDVNKLKEAAKTFKLGDGLGLTMSRTKSINAGSQDLGQMLSQPSSSTVATTTAPSSASAPVDPFAMSSWTQQPQPVSQPAPPGVAAPIPEDFFQNTIPSVEVAKTLPPPGTYLSKMDQAARAAIAAQGGPNQANNTPLPDIGLPDGGVPQQYPQQTSQQPGAPFQTVGLPDGGVRQQYPGQNQVPSQVPVSTQPLDLSVLGVPNTGDSGKPPGQPQSPPASVRPGQVPRGAAAPVCFKTGLAHLEQNQLPDALSCFDEAFLALAKDQSRGADIKAQATICAQYKIAVTLLREILRLQRVQGASALSAKDEMARLSRHLASLPLLAKHRINCIRTAIKRNMEVQNYGYSKQMLELLLSKAPASKQEELRGLVDLCVQRGTSNKSIDPLEDPSQLCSATLSRLSTIGYDVCDLCGAKFAALSSPGCIICGMGSIKRSDALAGPAPVSTPFG
Protein: Gap junction alpha-8 protein (Connexin-45.6) (Cx45.6) (P36381)
Organism: Gallus gallus (Chicken)
Function: Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8049527}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55917}. Cell junction, gap junction {ECO:0000305|PubMed:8049527}.
Interaction partners:
- Lens fiber major intrinsic protein
- Alpha-crystallin A chain
- Filensin
- Gap junction alpha-3 protein
- Beta-crystallin B2
- Gap junction alpha-1 protein
- Beta-crystallin B1
- Alpha-crystallin B chain
Sequence:
MGDWSFLGNILEQVNEQSTVIGRVWLTVLFIFRILILGTAAELVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLVYFGHAVHHVRMEEKRKEREEAERRQQAEVDEEKLPLAPNQNKGNNPDGTKKFRLEGTLLRTYILHIIFKTLFEVGFIVGQYFLYGFRILPLYRCGRWPCPNLVDCFVSRPTEKTIFIMFMLVVAAVSLFLNLVEISHLILKRIRRALRRPAEEQMGEVPEKPLHAIAVSSIPKAKGYKLLEEEKPVSHYFPLTEVGVEPSPLPSAFNEFEEKIGMGPLEDLSRAFDERLPSYAQAKEPEEEKVKAEEEEEQEEEQQAPQEEPGVKKAEEEVVSDEVEGPSAPAELATDVRSLSRLSKASSRARSDDLTV
Protein: GATA zinc finger domain-containing protein 1 (Ocular development-associated gene protein) (Q8WUU5)
Organism: Homo sapiens (Human)
Function: Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3).
Subcellular location: Nucleus {ECO:0000269|PubMed:21965549}.
Interaction partners:
- PHD finger protein 12
- Lysine-specific demethylase 5A
- BRCA2-interacting transcriptional repressor EMSY
- Mortality factor 4-like protein 1
- Paired amphipathic helix protein Sin3b
- Histone-binding protein RBBP7
- Histone deacetylase 1
- Ankyrin repeat and IBR domain-containing protein 1
- Histone deacetylase 2
Sequence:
MPLGLKPTCSVCKTTSSSMWKKGAQGEILCHHCTGRGGAGSGGAGSGAAGGTGGSGGGGFGAATFASTSATPPQSNGGGGGKQSKQEIHRRSARLRNTKYKSAPAAEKKVSTKGKGRRHIFKLKNPIKAPESVSTIITAESIFYKGVYYQIGDVVSVIDEQDGKPYYAQIRGFIQDQYCEKSAALTWLIPTLSSPRDQFDPASYIIGPEEDLPRKMEYLEFVCHAPSEYFKSRSSPFPTVPTRPEKGYIWTHVGPTPAITIKESVANHL
Protein: Hum-2 (Q17383)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MFNYSKIFQIHRACSPNRKKIGSIQYGRRRHSWQGPVVPAAKLQVLIKGVRIWHRHPTLVWIGATLEEDITFQTRNVRIRLEDDTEVEYAIKSLDQLPFLRNPAFLVGKDDLTLLSYLHEPAVLHNLQVRFVKGSSIYTYCGIVLVAINPYADCSHIYGEEIIQVYRGAGKSAREMDPHIFAVAEEAHFDMGAFGKSQSIIVSGESGAGKTVSAKFVMRYLASVAASKTRNGGTTSIEARVLASNPIMESIGNAKTIRNDNSSRFGKFIQINFCERGRRIVGAEMKTYLLEKSRLVFQAPGERNYHIFYQLCAARNHQVLKDLHLGPCESYSYLTQGGDSRIPGVDDKADFEALLKALQLLGFDEKQMSDVFRLLAGLLLLGNVHFENGEGSSAVSASSCQEISRLCREFWKISESDLRIWLTRREIRAVNEIVTKPLTKNEAVRSRDALTKMLYSHLFGWLVDKINEALNEKDKLDGTNQKKRPDRFIGVLDIYGFETFDVNSFEQFSINYANEKLQQQFNQHVFKLEQEEYIREEIEWVRVDFHDNQPAIDLIEGPVGMINLLDEQCKRLNGSDADWLSQLQNSTELKRNPQLAFPKVRSNDFIVRHFAADVTYSTDGFVEKNRDAIGEQLLDVVVASKFPFIRTVIGSTAPTSVSSSSSSSTPGKRTIKKTVASQFRDSLKELMSVLCSTRPHYVRCIKPNDSKISFDFEPKRAIQQLRACGVLETVRISAAGFPSRYPYEEFARRYRVIYTKEAALWRDKPKQFAELACQQCLEEGKYAVGKTKIFLRTGQVAVLERVRLDTLAAAATVIQKMWKGFLARRKYETMRRSLLIVQASLKAFLAFRRIKYLQMHRAVIVMQSAVRGYLERRKYEQIRDSIIGIQAMFKANRVRRYVEKLRYEKSAITIQAAWRGYLARREQIANRKKVVMVQCAVRKWLAKRRLRELKIEARSVGHLQKLNTGLENKIIELQMRLDIANARTKEEAEKFATASKNLQKTKADLAMMEAERLTLLEARNRVEVLQEEVERLETECDLKEAQRGGMETKMVELQSRLDQFQMQSESGQTIVELTEQLEKAKADRVLWDEERQRMEAALNTERSARNALDAEMAAMREQLMKNVDLFESSTFQKRPSQKKNRDDDSCSRTTSNLSQLTGSFTAETINGVHSTSRGSPEVLLDNMASTFEQLRMINDLRQRNEHCQRETERMKAIIEASTLIETLDKKTSLKAFESIRVGELEGAYNRLKNDMERLVSGENGATHSVFERIMEENERLREEAVELRSMLSSHFEKQSVAGSSGYRRSPRPDSGHCSGADSEDGSSGADLEEDLCIERQCRHLKNLAENLTKMLTNQNLEIERLQQQLRFSESQTVFRPSDCSLDEAVRGAHKQTQLLAQQNMDLNDKLTRQSEELAEARAQLRGYSGPLGLENASDEEIIRLEAFEKGSIKHSGFLEVYNVPEFARIIVCELKPTLARLLTKNLPAYLLVAAFRNHDEKRDETALTGLFSSVHLVLKDTISRSHDLDLLSLWLVNLWRLFNLLRQYSGEDSQPEWHVANTETQNSYRFKAYDVAPIRDQLKLRIEECYTSLMKKAIEHVLSPKIVPGILQHESSSDLMTAGQERRDRNSGSVESQRKSLDDLLQFMEIVHTKLTTYGGDDIVVKQVIGQMARWMCALALNYMMFRRELCNFEKAIQIKHNVTQIQNWLNAKGLSDCRDHFEPLVQACHLLQSRKDPSNLDTLCGEMTSRLKPRQVVAILQHYDPSDEMEDGLSPEFLVQIQKKLNERAIANNDPIEDKDKLIMLGTYLPPFDTQPFSYSDFPLETLSLPSCLHMQSVCRLV
Protein: Probable WRKY transcription factor 17 (WRKY DNA-binding protein 17) (Q9SJA8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
Sequence:
MTVDIMRLPKMEDQTAIQEAASQGLKSMEHLIRVLSNRPEERNVDCSEITDFTVSKFKKVISLLNRSGHARFRRGPVHSPPSSSVPPPVKVTTPAPTQISAPAPVSFVQANQQSVTLDFTRPSVFGAKTKSSEVVEFAKESFSVSSNSSFMSSAITGDGSVSKGSSIFLAPAPAVPVTSSGKPPLSGLPYRKRCFEHDHSEGFSGKISGSGNGKCHCKKSRKNRMKRTVRVPAVSAKIADIPPDEYSWRKYGQKPIKGSPHPRGYYKCSTFRGCPARKHVERALDDSTMLIVTYEGEHRHHQSTMQEHVTPSVSGLVFGSA
Protein: Stathmin-3 (SCG10-like protein) (Q9JHU6)
Organism: Rattus norvegicus (Rat)
Function: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.
Subcellular location: Golgi apparatus {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:16038898}.
Interaction partners:
Sequence:
MASTVSAYKEKMKELSVLSLICSCFYSQPHPNTIYQYGDMEVKQLDKRASGQSFEVILKSPSDLSPESPVLSSPPKRKDASLEELQKRLEAAEERRKTQEAQVLKQLAERREHEREVLHKALEENNNFSPLAEEKLNYKMELSKEIREAHLAALRERLREKELHAAEVRRNKEQREEMSG
Protein: Casein kinase I gamma (CKI-gamma) (EC 2.7.11.1) (Q8WQ99)
Organism: Caenorhabditis elegans
Function: Involved in the asymmetric cell division of the embryo downstream of par-2 and par-3 by regulating the asymmetric cortical distribution of pkk-1, a phosphatidylinositol 4,5-bisphosphate-producing enzyme, which in turn regulates the asymmetrical distribution of grp-1, grp-2 and lin-5.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:18694560}. Cytoplasm {ECO:0000269|PubMed:18694560}. Note=Cortical localization during all cell cycle stages. In the cytoplasm, forms punctate structures around the asters during mitosis. Enriched in the anterior region of the 1 cell-stage embryo. {ECO:0000269|PubMed:18694560}.
Interaction partners:
- Glycolipid transfer protein domain-containing protein
- Glycolipid transfer protein domain-containing protein
- G-protein regulator 1
- Serine/threonine-protein phosphatase 6 catalytic subunit
- Spindle apparatus protein lin-5
Sequence:
MTNTRGSNSATSASTTNSQGVLMVGPNFKVGKKIGCGNFGELRLGKNLYNNEHVAIKLEPMKSKAPQLHLEYRFYKLLGQAEGLPQVHYFGPCGKYNALVMELLGHSLEDLFDLCDRHFSLKTVAMVAMQLIRRIEYVHTKHLIYRDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRQTAVEVLCEGFPDEFAQYLRYARRLDFFETPDYDFCYNLFKSVLDRLGATYDYEFDWTPKLNNVSTPSGSLHTSESKDVKRTDRGELKVSQAAAHAQFGSTQVINSNAGEVVEESRNTEGRTAAGDNSSGEVKCCCFRRRRRKHNNATPATQK