wanglab/gogpt-training-data huggingface dataset:
Protein: Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin) (P12242)
Organism: Mus musculus (Mouse)
Function: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:23063128}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04633}.
Interaction partners:
- Lipid transferase CIDEA
- Peroxisome proliferator-activated receptor gamma
- Beta-3 adrenergic receptor
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Histone-lysine N-methyltransferase PRDM16
- Adiponectin
- Cytochrome c oxidase subunit 8B, mitochondrial
- Peroxisome proliferator-activated receptor alpha
- Type II iodothyronine deiodinase
- Leptin
Sequence:
MVNPTTSEVQPTMGVKIFSAGVSACLADIITFPLDTAKVRLQIQGEGQASSTIRYKGVLGTITTLAKTEGLPKLYSGLPAGIQRQISFASLRIGLYDSVQEYFSSGRETPASLGNKISAGLMTGGVAVFIGQPTEVVKVRMQAQSHLHGIKPRYTGTYNAYRVIATTESLSTLWKGTTPNLMRNVIINCTELVTYDLMKGALVNNKILADDVPCHLLSALVAGFCTTLLASPVDVVKTRFINSLPGQYPSVPSCAMSMYTKEGPTAFFKGFVASFLRLGSWNVIMFVCFEQLKKELMKSRQTVDCTT
Protein: Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4] (Q9BH11)
Organism: Bos taurus (Bovine)
Function: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
Subcellular location: [Processed zona pellucida sperm-binding protein 4]: Zona pellucida {ECO:0000250|UniProtKB:Q00193}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q00193}; Single-pass type I membrane protein {ECO:0000255}.
Interaction partners:
- Zona pellucida sperm-binding protein 2
- Growth/differentiation factor 9
- Zona pellucida sperm-binding protein 3
- NACHT, LRR and PYD domains-containing protein 5
- Oviduct-specific glycoprotein
- Clarin-1
- 5-hydroxytryptamine receptor 1D
- Bone morphogenetic protein 15
- D
Sequence:
MWLLLQLVWLCFLLSLGLNSWHQSKVPEYPDELRCGLRSFQFTINPLSQETETPPVLVAWDNHGLPHSLQNDSDCGTWVSEGPGSSLVGEASYSGCYVTEWESYYIMTVGIERAGVSGSGAFIETKLFKCPVNLPDVPNAGLCDSVPVWDRLPCAPSPITQGDCKQLGCCYNSEEVISCYYGNTVTSHCTQDGHFSIAVSRNVTSPPLLLNSVHLAFRNDSECKPVMATHTFVLFRFPFTTCGTTKQITGKQAVYENELVAARDVRTWSRGSITRDSTFRLQVSCSYSASSSALPVNVQVLTLPPPLPETQPGNLTLELKIAKDKRYRSYYTASDYPVVKLLRDPIYVEVSIHQRTDPSLELRLDQCWATPGADALLQPQWPLLVNGCPYTGDNYQTKLIPVWEASDLPFPSHYQRFSISTFSFVDSVAKRALKGPVYLHCSASVCQPAGTPSCVTLCPARRRRSSDIHFQNNTASISSKGPLILLQAIQDSSEKLHKYSRSPVDSQALWVAGLSGILIVGALFMSYLAIRKWR
Protein: Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase (Acyl-coenzyme A:Isopenicillin N acyltransferase) (IPN:acyltransferase) (Q3HUS0)
Organism: Penicillium chrysogenum (Penicillium notatum)
Interaction partners:
Sequence:
MLHILCQGTPFEIGYEHGSAAKAVIARSIDFAVDLIRGKTKKTDEELKQVLSQLGRVIEERWPKYYEEIRGIAKGAERDVSEIVMLNTRTEFAYGLKAARDGCTTAYCQLPNGALQGQNWDFFSATKENLIRLTIRQAGLPTIKFITEAGIIGKVGFNSAGVAVNYNALHLQGLRPTGVPSHIALRIALESTSPSQAYDRIVEQGGMAASAFIMVGNGHEAFGLEFSPTSIRKQVLDANGRMVHTNHCLLQHGKNEKELDPLPDSWNRHQRMEFLLDGFDGTKQAFAQLWADEDNYPFSICRAYEEGKSRGATLFNIIYDHARREATVRLGRPTNPDEMFVMRFDEEDERSALNARL
Protein: Small ribosomal subunit protein uS14m (28S ribosomal protein S14, mitochondrial) (MRP-S14) (S14mt) (Q6B860)
Organism: Bos taurus (Bovine)
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10938081, ECO:0000269|PubMed:24799711}.
Interaction partners:
- Small ribosomal subunit protein uS11m
- Small ribosomal subunit protein uS9m
- Small ribosomal subunit protein bS6m
- Small ribosomal subunit protein uS7m
- Small ribosomal subunit protein uS5m
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS12m
- Small ribosomal subunit protein uS15m
- Small ribosomal subunit protein mS35
Sequence:
MATSMLGSLLRIVRQVVPSSASGQARSYYVDWRMLRDVKRRKMAYEYADERLRINSLRKNTILPKHLQEVADEEIAALPRDSCPVRIRNRCVMTSRPRGVKRRWRLSRIVFRHLADHGQLSGIQRAIW
Protein: site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) (P96868)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- site-specific DNA-methyltransferase
- Possible transcriptional regulatory protein
- Uncharacterized protein Rv1359
- Transcriptional regulatory protein EmbR
- Helicase ATP-binding domain-containing protein
- Possible transcriptional regulatory protein
- Transcriptional regulatory protein
- Putative mycofactocin biosynthesis transcriptional regulator MftR
- Putative antitoxin HigA3
- NAD-dependent protein deacylase
Sequence:
MQPSHPTRPGAVIRYVGSSLDTCPMTTFAGKTAASADKVRGGYYTPPAVARFLAHWVHQAGPKILEPSCGDGRILRELSAITDHAHGVELVAREAKKSRDFASVDTENLFTWLHKTQLGSWDGVAGNPPYIRFGNWASEQRDPALELMRRVGLRPTKLTNAWVPFVVASTTLARDGGRVGLVVPAELLQVTYAAQLREFLLSRYREITLVTFERLVFDGILQEVVLFCGVVGPGPAHIRTVRLGDANDLNALGDKDFTNESAPALLHEKEKWTKYFLDPAQIRLLRGLKQSATMIRLGELADVDVGIVTGRNSFFTFTDAKAQALGLRAHCVPLVSRSAQLSGLIYDEDCRACDVAGNHRTWLLDAADYPTDPALVAHITAGEAAGVHLGYKCSIRKPWWSTPSLWMPDLFMLRQIHFAPRLTVNAAAATSTDTVHRVRLDPNVDPATLAAVFHNSATFAFAEIMGRSYGGGILELEPREAEQLPMPPPAYGSAELAQDVDLLLKANEIDKALDVVDRHVLIDGLGLSPRLVAGCRAAWLTLRDRRTKRGSRR
Protein: Pathogenesis-related homeodomain protein (PRHA) (P48785)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Specifically binds to the fungal elicitor-responsive DNA element, 5'-CTAATTGTTTA-3', of the gene PR2 promoter.
Subcellular location: Nucleus.
Interaction partners:
- Protein MRG1
- Protein MRG2
- Zinc-finger homeodomain protein 12
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- Zinc-finger homeodomain protein 13
- Developmentally-regulated G-protein 1
- Zinc-finger homeodomain protein 6
- Zinc-finger homeodomain protein 7
- WD-40 repeat-containing protein MSI3
- WD-40 repeat-containing protein MSI2
Sequence:
MEESETKGRISQETDKACVSVERIGSTLLSSFVKKGKEVSNKRNSKQNKRKAEEELCSKSRTKKYSRGWVRCEEMEEEKVKKTRKRKSKRQQKDNKVEVDDSLRLQRRTRYLLIKMKMQQNLIDAYATEGWKGQSREKIRPDKELERARKEILNCKLGLRDAIRQLDLLSSVGSMEEKVIASDGSIHHDHIFCAECNSREAFPDNDIILCDGTCNRAFHQKCLDPPLETESIPPGDQGWFCKFCDCKIEIIDTMNAQIGTHFPVDSNWQDIFNEEASLPIGSEATVNNEADWPSDDSKDDDYDPEMRENGGGNSSNVSGDGGGDNDEESISTSLSLSSDGVALSTGSWEGHRLSNMVEQCETSNEETVCGPRQRRTVDYTQLYYEMFGKDAVLQEQGSEDEDWGPNDRRKRKRESDAGSTLVTMCESSKKDQDVVETLEQSERDSVSVENKGGRRRMFRLPRNAVEKLRQVFAETELPSKAVRDRLAKELSLDPEKVNKWFKNTRYMALRNRKTESVKQPGDSKTVSGGDSGPEAVMENNTETNEVQDTLDDTVPPGFDATNQNILSPCNNNQEEFQQENVSFPSPTDESQQYLEQNDSSFVLVPHEKQSSEISLKTAVEENETESKMMKEPHEELSSEMSLKTAAEEKETESKMIEEPHEELSREMSLKTAVEEKETESKMMEEPHDELNSEMSLSTAVEEKETGSKMTEESHEELSNEMSLEEKETGRKMTEEEELEAVMEMLCRTENKLLDVTQRLDRFKTPKGRKKLGNSSSPLLEEDSVVYVPIAEIKEKR
Protein: Basic-leucine zipper (BZIP) transcription factor family protein (Q8L5Y2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Basic leucine zipper 9
- Basic leucine zipper 34
- Dihydropyrimidine dehydrogenase
Sequence:
MELEPISSSCCSSSSSSSGEENTAAANMTEMEAAEALADLAQLAIMREQVFESAASWGSKGKRVRKRVKTESPPSDSLLKPPDSDTLPTPDLAEERLVKEEEEEEEVEPITKELTKAPVKSEINGETPKPILASTLIRCSRSNGCGRSRQNLSEAEREERRIRRILANRESARQTIRRRQAMCEELSKKAADLTYENENLRREKDWALKEFQSLETINKHLKEQVLKSVKPDTKEPEESPKPSQVEMSTSSTPFYFYNQNPYQLFCWPHVTQSSNPMISPLEFPTSGGASAKTITTQEHENAADDNGQKTHFYVVPCPWFLPPPDHSNGVPFGLQDTQRGTFSNGHHIDDSSARPMDVTETPRSHLPTRIKEEDSGSPETRPLYDLNESATEVLSEGGDGFPVTQQAYSLKHEDVSETTNGVTLMPPGHHVLISLPEKKHGSLAAAEARKRRKELTRLKNLHGRQCRMQVG
Protein: Map1lc3b protein (Microtubule-associated protein 1 light chain 3 beta) (Microtubule-associated protein 1-light chain 3B) (Microtubule-associated proteins 1A/1B light chain 3B) (Q7ZUD8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
- NBR1 autophagy cargo receptor b
- Protein ref
- Ubiquitin-like modifier-activating enzyme ATG7
- Cysteine protease ATG4B
- Ubiquitin-like-conjugating enzyme ATG3
- NBR1 autophagy cargo receptor a
- Ubiquitin-like protein ATG12
- Cysteine protease
- Autophagy protein 5
- Beclin-1
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPNKIPVIIERYKGEKQLPILDKTKFLVPDHVNMSELIKIIRRRLQLNSNQAFFLLVNGHSMVSVSTAISEVYERERDEDGFLYMVYASQETFGFQ
Protein: Probable RNA polymerase II nuclear localization protein SLC7A6OS (Q9VIR9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerase II subunit RPB11
Sequence:
MPAVVRIKRRIDEEPQTAFVLNGKRRRLHNDENALEDAGAVAGAVAGAVASDKDELTTVLKFAGTLEKQDDCATRKFAAARLNKAAARDLVQQQRSNDAAIASALRRDRQRQEAQENSREQRFRVVNCLRSTLENSAAEAECPESQSHESSSHITIVDIESQQQQHMGTASAAAEEQQQQEIAPSQDQQQPADSDVGYVYDLYVPENEMQAAYVDMMDDNYLSVIPVGEIVLEDCYNDQDEDYDSEDSNQENYFTNDYPDDDEAGAMGSDDELCRQMNKFMLDDDEDEFASTSDDDDYATFRDPYVHTIDTEEDSFVDDVDFYNVDRERGSAYERYKRRILKELEGQEEEDEDDDDDDDSFASADGE
Protein: Amino acid transporter 1, putative (Q57V82)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MISINAQPPNSATYPRDDHGSAEAGQANAEVERPQTKKQKDGGGCFARVSLFMATIIPPGGIAASAFNIGSTTIGAGIFGLPAAANSSGLVMAMIYLIIITAMTIFSIYALGVAAERTNIRTYEGVARALLGPWGAFCTAAARTFFCFSACVAYVISVGDILSATLKGTNAPDFLKQKSGNRLLTSLMWLCFMLPLVIPRHIDSLRYVSTIAFSLMIYVVVVVVVHSCMNGLPENIKNVSVGKDDNAEIILFNSGNRAIEGLGVFIFSYLFHITAYEVYMDMTNRSVGKFVLVVTIAMGMCLPIYALTAFFGYMDFGRNVTGSVLLQYDPVNYPAIMVGFVGVLVKLCVSYALLGLACRNALYDVIGWDFREVAFWKHCIAVVTLSVVMLLCGLFIPKITTVFGFAGSISGGLLGFILPALFFMYSGGFTWQKVGPFYYISTYVLLITGVIAAVFGTGATIWAVTVG
Protein: Photosystem I reaction center subunit PSI-N, chloroplast, putative / PSI-N, putative (PSAN) (F4KC80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000256|ARBA:ARBA00004622}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004622}; Lumenal side {ECO:0000256|ARBA:ARBA00004622}.
Interaction partners:
Sequence:
MAAMNSSVLTCSYAIAGSGSVELNQKVGLVNSSVGFGQKKQMIMPVIKAQRVVGDDVDGSNGRRSAMVFLAATLFSTAAVSASANAGVIDEYLERSKTNKELNDKKRLATSGANFARAFTVQFGSCKFPENFTGCQDLAKQKFHLSQKILLWNAKARTSTSVVPMFSGNGEELCLFSSILI
Protein: ATP-binding cassette sub-family G member 5 (EC 7.6.2.-) (Sterolin-1) (Q99PE7)
Organism: Rattus norvegicus (Rat)
Function: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9H222}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H222}. Apical cell membrane {ECO:0000250|UniProtKB:Q9H222}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H222}.
Interaction partners:
- ATP-binding cassette sub-family G member 8
- NPC1-like intracellular cholesterol transporter 1
- Cytochrome P450 7A1
- Oxysterols receptor LXR-alpha
- ABC-type oligopeptide transporter ABCB9
- Bile acid receptor
- Sterol regulatory element-binding protein 2
- Hepatic sodium/bile acid cotransporter
- Scavenger receptor class B member 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Sequence:
MSELPFLSPEGARGPHNNRGSQSSLEEGSVTGSEARHSLGVLNVSFSVSNRVGPWWNIKSCQQKWDRKILKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQDCVSYLLQSDVFLSSLTVRETLRYTAMLALRSSSADFYDKKVEAVLTELSLSHVADQMIGNYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANHIVLLLVELARRNRIVIVTIHQPRSELFHHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLESAFRQSDICHKILENIERTRHLKTLPMVPFKTKNPPGMFCKLGVLLRRVTRNLMRNKQVVIMRLVQNLIMGLFLIFYLLRVQNNMLKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYQKWQMLLAYVLHALPFSIVATVIFSSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVLLGMVQNPNIVNSIVALLSISGLLIGSGFIRNIEEMPIPLKILGYFTFQKYCCEILVVNEFYGLNFTCGGSNTSVPNNPMCSMTQGIQFIEKTCPGATSRFTTNFLILYSFIPTLVILGMVVFKVRDYLISR
Protein: Purine-cytosine permease FCY22 (PCP FCY22) (Cytosine/purine transport protein FCY22) (Fluorocytosine resistance protein 22) (Q12119)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Probable purine-cytosine permease.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Epsin-2
- Epsin-1
- Cytosine deaminase
Sequence:
MPEKLAMSMVDIKDAGSELRDLESGALDTKSSAADVYYEGVELHRTNEFIDNKPSFFNRIAAALNAETKGIEPVTEDEKNDDSILNAATIWFSANMVIVAYSVGALGPLVFGLNFGQSVLVIIFFNILGLIPVALFSLFGVELGLRQMILSRYLAGNITARFFSLVNVIACVGWCVLNISVSAQLLNMVNEGSGHNCPIWAGCLIIAGGTVLVTFFGYSVVHAYEKWSWVPNFAAFLVIIAQLSRSGKFKGGEWVGGATTAGGVLSFGSSVFGSAAGWATYAADYTVYMPKTTSKYKIFFSVVAGLAFPLFFTMILGAACGMAALNDPTWKSYYDKNAMGGVIYAILVPNSLNGFGQFCCVLLALSTVANNVPGMYTVALSAQALWAPLAKIPRVVWTMAGNAATLGISIPATYYFDGFMENFMDSIGYYLAIYIAIACSEHFIYRRSFSAYNIDDWDNWEHLPIGIAGTAALIAGAFGVALGMCQTYWVGEISRLIGEYGGDIGFELGGSWAFIIYNIVRPLELKYFGR
Protein: Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (P68103)
Organism: Bos taurus (Bovine)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P68104}. Nucleus {ECO:0000250|UniProtKB:P68104}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P68104}. Cell membrane {ECO:0000250|UniProtKB:P68104}. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens. Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B. {ECO:0000250|UniProtKB:P68104}.
Interaction partners:
- Elongation factor 1-gamma
- Elongation factor 1-beta
- Small ribosomal subunit protein uS5
- GTP-binding nuclear protein Ran
- GTP-binding nuclear protein Ran
- 3'-phosphoadenosine 5'-phosphosulfate synthase 1.
- 3'-phosphoadenosine 5'-phosphosulfate synthase 2
- Tyrosine-protein phosphatase non-receptor type
- Elongation factor 1-alpha 2
- Large ribosomal subunit protein uL4
Sequence:
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
Protein: Ras guanine nucleotide exchange factor H (RasGEF domain-containing protein H) (Q8IS16)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Promotes the exchange of Ras-bound GDP by GTP. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20493808}. Note=The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells (PubMed:20493808). Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1 (PubMed:20493808). {ECO:0000269|PubMed:20493808}.
Interaction partners:
- Ras guanine nucleotide exchange factor A
- Protein phosphatase 2A scaffold subunit
- Protein phosphatase 2A catalytic subunit B
- Sca1 complex scaffold protein scaA
- Sca1 complex protein phr
Sequence:
MSNTNINVQSSTPKKSLGSSQYSLAGSSSSNLNNINNNNNNNNNNNNNSTGQENSIDDSGSSSFVNFPASEWLSKAMHKHPDILELRERTRPITQVKSYSRNKRSSKTEASHSINDTMLLKLIMQYFHEENLTTSLKKIQEETKVQFTPNEVDKDSLENLLRIGIKDTNWFGPLEDIEDADPEVETYHSYISEDSLNENGLEGEGNLIEDRYDESQISRNPDGTIKAATFNRLLLWLIGNFNGPDVNEFKKIFFLTYPSFTTAEAILNKFTQIYQLFDNIESAQVICFIRFWIEQHPTDFNEKLLAILNNFIEHQVAASHAKQLRAVINLKIENYKEARKEIKDPPEPKVPKNIFSPTLTFDDIDEEEIARQLCCIDFALYELIKPSEFLIKGWTKPQYRNKAVNLLNMMRRFNDFTKWIAASILNEQNSKGRSKLLGRFLKISEHLRANNNFHSLMAIYGGINNTHVFRTKAIRKDLSRQQQETYAELEKLFASENSFRNYRIAYKDAKPPCIPFLGIHLRDLAFVDESNPDRINNLLNLNKRRVIWRVIVNTMRYQPIPYYFLKVHQISLFLTELKTESEQPQLTLDLSSHDTVLPSSPSSK
Protein: Elongation factor 1-alpha (Q3LUM5)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Interaction partners:
- Elongation factor 1-gamma-like
- Elongation factor 1-gamma-like
- Elongation factor 1-gamma-like
- Elongation factor 1-beta 2-like isoform X1
- Elongation factor 1-beta 2-like
- Elongation factor 1-delta-like
- Elongation factor 1-delta-like
- Elongation factor 1-beta 2-like
- GTP-binding nuclear protein
- GTP-binding nuclear protein
Sequence:
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKLGGIDKRVIERFEKEAAEMNKRSFKYAWVLDKLKAERERGITIDIALWKFETTKYYCTVIDAPGHRDFIKNMITGTSQADCAVLIIDSTTGGFEAGISKDGQTREHALLAFTLGVKQMICCCNKMDATTPKYSKARYDEIVKEVSSYLKKVGYNPDKIPFVPISGFEGDNMIERSTNLDWYKGPTLLEALDQINEPKRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFGPSGLTTEVKSVEMHHEALTEALPGDNVGFNVKNVAVKDLKRGFVASNSKDDPAKEAANFTSQVIIMNHPGQIGNGYAPVLDCHTSHIAVKFAELLTKIDRRSGKELEKEPKFLKNGDAGMIKMIPTKPMVVETFSEYPPLGRFAVRDMRQTVAVGVIKSVEKKDPTGAKVTKSAAKKK
Protein: RNA helicase (EC 3.6.4.13) (B0S6P6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Serine/threonine-protein kinase TBK1
- DEAD-box helicase 3 X-linked b
- Elongation factor Tu GTP-binding domain-containing 2.
- ATP-dependent RNA helicase DHX29
- Pre-mRNA-processing factor 6
- Cell division cycle 5-like protein
- ATP synthase subunit beta
- ATP synthase subunit alpha
- ATP synthase subunit gamma.
- DEAH
Sequence:
MSHVVVDGSHGLDQQLAVLDLNSADGQGVGTGRRYIPPHLRNKDASKNDSPGWDGSRTNGFVNGYHDSRMNGTANFARGPLRNDRGGRGGFRGNRNGASFNQPVHNAGYGTYENKDGGWNSVVNRDAYASFGGRSDRGKSAFFNDRGASSRGRYERGGFGGGTGGNSRWVEESRDEEDWSKPMPPNERLEHELFSASNTGINFEKYDDIPVEATGTNSPGHIESFHDVDMGEIIMGNITLSRYTRPTPVQKYAIPIIKTKRDLMACAQTGSGKTAAFLLPVLSQIYSEGPGEALQATKASTQQENGKYVRRKQYPISLVLAPTRELALQIYDEARKFAYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGSRQTMMFSATFPKEIQILARDFLEEYIFLAVGRVGSTSENITQKVVWVEENDKRSFLLDLLNATGKDSLTLVFVETKKGADALEDFLYREGYACTSIHGDRSQRDREEALHQFRSGRCPIMVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFYNDKNSNITKDLLDILVEAKQEVPSWLENLAYEHQHKSTNRGRPKRFSGGFGARDYRQMPGGGNTFGNRGARNTGGHGGNRGFGGNKGGFGSFGGDSYGGTYGNYGGNYTQVDWWGN
Protein: Dynein light chain Tctex-type 4 (Tctex1 domain-containing protein 4) (Q8CDY7)
Organism: Mus musculus (Mouse)
Subcellular location: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q5JR98}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:23789093}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q5JR98}. Cytoplasm {ECO:0000269|PubMed:23789093}. Nucleus {ECO:0000269|PubMed:23789093}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q5JR98}. Note=Present along the entire length of the flagellum, including principal and endpiece, and more predominantly in the midpiece region. {ECO:0000250|UniProtKB:Q5JR98}.
Interaction partners:
- Dynein light chain roadblock-type 2
- Dynein light chain roadblock-type 1
- Dynein light chain Tctex-type 1
- Dynein light chain Tctex-type 3
- Cytoplasmic dynein 2 light intermediate chain 1
- Cytoplasmic dynein 1 intermediate chain 1
- Cytoplasmic dynein 1 light intermediate chain 2
- Cytoplasmic dynein 1 light intermediate chain 1
- Dynein light chain 2, cytoplasmic
- Dynein light chain
Sequence:
MACRTLPSRRQEEETTKDLALKLPPGKPGGHLPSIDETRPIGPGPASRRGSLPGLHPSFSRRNSLAGPLVGPGGRRPSLGPVPPLGSRVSFSGLPLMLPRRMAPSYRLEPAPGEHWEAAGAQRALEAALTTQLNGVCYCGSEAGKLVQALCEQIHTRVRELNLPRYKLVCNVVLGPREGQGVHVVSRALWDAVHDGLASATFTNPSLFAVATVHAVYWE
Protein: Phospholipase A2 crotoxin basic subunit CBc (CB1) (CTX subunit CBc) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (P62022)
Organism: Crotalus durissus terrificus (South American rattlesnake)
Function: Heterodimer CA-CB: Crotoxin is a potent presynaptic neurotoxin that possesses phospholipase A2 (PLA2) activity and exerts a lethal action by blocking neuromuscular transmission (By similarity). It consists of a non-covalent association of a basic and weakly toxic PLA2 subunit (CBa2, CBb, CBc, or CBd), with a small acidic, non-enzymatic and non-toxic subunit (CA1, CA2, CA3 or CA4) (By similarity). The complex acts by binding to a specific 48-kDa protein (R48) receptor located on presynaptic membranes, forming a transient ternary complex CA-CB-R48, followed by dissociation of the CA-CB complex and release of the CA subunit (By similarity). At equilibrium, only the CB subunits remain associated with the specific crotoxin receptor (By similarity). In addition to neurotoxicity, crotoxin has been found to exert myotoxicity, nephrotoxicity, and cardiovascular toxicity. Moreover, anti-inflammatory, immunomodulatory, anti-tumor and analgesic effects of crotoxin have also been reported.
Subcellular location: Secreted {ECO:0000269|PubMed:8033889}.
Interaction partners:
Sequence:
MRALWIVAVLLVGVEGHLLQFNKMIKFETRKNAIPFYAFYGCYCGWGGRGRPKDATDRCCFVHDCCYGKLAKCNTKWDIYPYSLKSGYITCGKGTWCEEQICECDRVAAECLRRSLSTYKYGYMFYPDSRCRGPSETC
Protein: Interleukin-22 (C5VUR1)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
Sequence:
MKFSTVQLVAAVVVVMSVCLLRESVAHSIHRPLSAPLHSADTDTMVQQVAQHAQSSDTDTDTKLMPDIDTKKNHRDICCLHANILDFYLSNILTTKEKQDKHHPKLPALKEDLARVSRDLKEHGCAIKHYNDHHHSIAFRKKLSEMEEGKGIKKAIGEIDILFTFLKDFCVHA
Protein: C-type natriuretic peptide 1 (A0A060XWG0)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003686}.
Interaction partners:
- C-type natriuretic peptide 3
- C-type natriuretic peptide 4
- Natriuretic peptide C
- C-type natriuretic peptide 3
- Guanylate cyclase domain-containing protein
- Guanylate cyclase
- Guanylate cyclase
- Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein
- Receptor ligand binding region domain-containing protein
- Guanylate cyclase
Sequence:
MLYPALLCAALLLIAPLGHTEGRTLHPSPDAIQFVEQFLDRYNDLTLDDLENLVSSQPEEPSSAFTSGVKVAEYPKWADIPAQGDSTWLRLLKGTLANQKRAVMDRSRRGWNRGCFGLKLDRIGSMSGLGC
Protein: Mitogen activated protein kinase, putative (EC 2.7.1.-) (Q381A7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDAYETLGMLGEGTYGVVVKARHRATSRIVAIKKYKQAEDDDHVRKTSLREVRVLKQLRHPNVIALLDVFRRDGKLYLVFEYVENTILQLIEEKKYGLSPDEVRRYTFQLLNGVSYCHAHNIIHRDVKPENILVSRDGVLKLCDFGFARQLSCRGNYTEYVATRWYRAPELLVGDVSYGKAVDVWAIGCVFSELSDGQPLFPGDSDLDQLSLIMRACGPVPQQMVSTFEHNALYRRVTFPNVDVEETLQQRFPTAASPWLEFLTSCLRMDPVERPSCTALMSMAYFTENNFRATYELELRELFQHCQPPLVDVAPTSPDHNFSREQQHQQQTLGNDRVDAELTLPRLAAPSLDAETTDKVDSAESKNTTMGVSSEVVGGVGGSVVVDSNSNSFHQLGALWSHYIGSTVGATMALSGELPNIGPRQAHPYPSGLPPGVQVTKPVPRSGTNSVGDKNYNGVQAMKVTGCLRLSAKNISRSPDVQRVKASAAQSGPKVKQAKSEVKPEQKREWKSCSALGKSVKPNYLFPLLPNGTNNSGITSYGPSGVAVGAGPAPQDACSPLVSKGLRPPSSNGIPGAGLHSNGSTTSFSAHKDEKMDLGCGEQNNNGSDHKQRKKHVKRTHDNGELEGPPRKVSDKPSSQHSVAGHRYSFRDGATKR