wanglab/gogpt-training-data huggingface dataset:
Protein: Metallophosphoesterase 1 (Post-GPI attachment to proteins factor 5) (K7EQV4)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004457}. Golgi apparatus, cis-Golgi network membrane {ECO:0000256|ARBA:ARBA00004257}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004257}.
Interaction partners:
Sequence:
MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVF
Protein: Alpha-mannosidase I MNS5 (EC 3.2.1.-) (Q9SXC9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Can convert Man(9)GlcNAc(2) and Man(8)GlcNAc(2) into N-glycans with a terminal alpha-1,6-linked Man residue in the C-branch. Functions in the formation of unique N-glycan structures that are specifically recognized by components of the endoplasmic reticulum-associated degradation (ERAD) machinery, which leads to the degradation of misfolded glycoproteins. Most likely generates N-glycan signal on misfolded glycoproteins that is subsequently recognized by OS9. Required for ERAD of the heavily glycosylated and misfolded BRI1 variants BRI1-5 and BRI1-9. Does not seem to play role in N-glycan processing of correctly folded proteins destined for secretion.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24737672}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Protein OS-9 homolog
- Alpha-mannosidase I MNS4
- Calnexin homolog 1
- UDP-glucose:glycoprotein glucosyltransferase
- ERAD-associated E3 ubiquitin-protein ligase component HRD3B
- Dol-P-Man:Man
- Calnexin homolog 2
- Calreticulin-3
- Calreticulin-2
- Alpha-1,2-mannosyltransferase ALG9
Sequence:
MSCPIHPRRLFLCLLISLTFFVVDPSSQHIEVKKKQMREKVREMFYHAYDNYMTYAFPHDELKPLTKSFTDSLSELGNLKLEHLPTDYNGSAVTLVESLSSLAILGNSTEFEKGVLWLSENLTFDIDARVNLFECNIRVLGGLISAHLLAIDPNNRLIQGSYNNQLLRLAEDLGKRFLPAFETPTGLPYAWINLKNGVMENETTETSTSGCGSLVLEMGALSRLTGDPRFESAALRALRQLWRMRSSLDLLGTTLDVVTGEWIEYSSSIGAGVDSFYEYLLKAYILFGKEDYWRMFHSAYLASQKYFRHGPWYHEANMWSGKPTYWQLTSLQAFWPGLQVLVGDIAAANSSHREFFHVWEKFGVLPERYLLDHQIIHPTMKYYPLRPELAESTFYLYQATKDPWYLDVGESMVKSLNLYTKVPGGFASVRDVTTMQLEDHQHSFFLAETCKYLYLLFDDSFVAKRNYIFTTEGHPIQVVSSWHEKLPETYFSGNWTLSKSGAWESRASALSLQVCPLISLNSRHPEQQRESACHVLDEQINHKCWSNKECGVDATTCRLRTCSGVGYCGLWNPL
Protein: Striatin-interacting protein 1 homolog isoform X3 (Striatin-interacting protein 2) (E7F9X6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MQQTDDMEGSMESPNLEFEYGDTDSFTAELSELYSYTEEPEFSLNRDYFEEDFKNHVKGRRWMELSVEEQRAYVMRLLDALEVTDRDKRLKVARAILYLAQGVFDECDTETDVLYWSRHNVFLLYDMGIFTALLELLSMEIDNNQACSSAVRKPAISLADSTELRVLLSIMYLMVETIRVEMESDSPERKAAREAFKMELGSPLYNGEPFALLLFTMVTKFCSMNAPHFPMKKVLLLLWKTILFTLGGFEELQEMKVRMRDHLNLPPLPEDSIKVVRNMRAASPPASAMELIEQQQQQKRGRRSRRSAFVDSLEGDSPYAKKQPLVKQDSLDTYNERDPFKNDDARDEEDDPEDVDSGIEGEVDPLDRDVIIQPPPPPPPLRPPTERMSFPKGLPWAPKVREKDIEHFLETSRNKFIGFTLGNDIDTLVGLPRPIHESVKTLKLHKYVSIAEVQIKREDELQQCPMTMGEEEVEETPTEILYLGMLPSLSQYVIALLKLLLAAAPTSKAKTDSINILADVLPEEMPITVLQSMKLGIDVNRHKEIIVKAISALLLLLLKHFKLNHIYQFEYVAQHLVFANCIPLILKFFNQNIMSYISAKNSICALDFPHCAVHEMPELTAESLEAGDSNQFCWRNLFSCINLLRILNKITKWKHSRTMMLVVFKSAPILKRALKVKQAMMQLYVLKLLKIQTKYLGRQWRKSNMKTMSAIYQKVRHRLNDDWAYGNDIDARPWDFQAEECALRESIEKFNTRRYDKNQNSEFAPVDNCLQSVLGQRVDLPEDFHYSYEMWLEREVFSQPIQWEGLLQAQ
Protein: SpoIVD-associated factor A (Morphogenetic protein SafA) (O32062)
Organism: Bacillus subtilis (strain 168)
Function: Probably involved in the assembly of some coat protein components implicated in both lysozyme resistance and germination. Could be required for the assembly of CotG. Associates with SpoIVD during the early stage of coat assembly.
Subcellular location: Spore cortex {ECO:0000269|PubMed:10714986}. Note=At the coat-cortex interface.
Interaction partners:
- Stage VI sporulation protein D
- Spore coat protein E
- Stage IV sporulation protein A
- Quinolinate synthase
- Spore coat protein GerQ
- Spore coat protein Z
- Stage V sporulation protein M
- Spore coat protein Y
- Spore coat protein X
- Sporulation cortex protein CoxA
Sequence:
MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMKIKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPPMPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEAMSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPVSPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGAPQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFSAPGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE
Protein: (E)-beta-caryophyllene synthase (EC 4.2.3.57) (Terpene synthase 23) (B2C4D0)
Organism: Zea mays (Maize)
Function: Component of the volatile terpenes biosynthesis pathways. Sesquiterpene synthase that converts farnesyl diphosphate to (E)-beta-caryophyllene. Involved in indirect defense by producing volatile signals that attract natural enemies of leaf herbivores such as Chilo partellus and root herbivores like the western corn rootworm (WCR, Diabrotica virgifera) and fall armyworm (Spodoptera littoralis and Spodoptera frugiperda). Deters leaf herbivores by triggering (E)-beta-caryophyllene production upon insect (stemborer C.partellus) egg deposition; (E)-beta-caryophyllene attracts the parasitic wasp Cotesia sesamiae which lays eggs on the larvae of C.partellus, which is ultimately fatal.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6Q3H2}.
Interaction partners:
Sequence:
MAADEARSVSRLHSEEDMHGKHHSTLWGDFFLHHVPCRPGQYLIMKDNVEIMKEEVKKMLLDVGSSDLSHKLDCIDTLERLGLDYHYTKEIDELMCNVFEARDQDLDLTTTSQLFYLLRKHGYHISSDVFLKFRDDKGDIVTNDARCLLRMYEAAHVRVNGEEILDNILIHTKRQLQCIVDDLEPTLQEEVRYALETPLFRRLNRVQARQFISTYEKSTTRINMLLEFSKLDFNILLTLYCEELKDLTLWWKEFQAQANTTIYARDRMVEMHFWMMGVFFEPQYSYSRKMLTQLFMIVSVLDDLYDSHCTTEEGNAFTAALQRWDEEGVEQCPTYLRTLYTNIRATIKAIEEDLNFQNNKHAKLVKGLIIDMAMCYNAETEWRDKKYVPATVDEHLKISARSSGCMHLVSQGFISMGDVATSEALEWASTYPKIVRAVCIIARLANDIMSYKREASNNTMVSTVQTCAKEYGTTTVEQAIEKIRELIEEAWMDITHECLRQPQPKALLERAVNLARTMDFLYKDADGYTDSRSIKGILDSLYVHLID
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 (J3KMX2)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSPGNRMPMAGLQVGPPAGSPFGAAAPLRPGMPPTMMDPFRKRLLVPQAQPPMPAQRRGLKRRKMADKVLPQRIRELVPESQAYMDLLAFERKLDQTIARKRMEIQEAIKKPLTQKRKLRIYISNTFSPSKAEGDSAGTAGTPGGTPAGDKVASWELRVEGKLLDDPSKQKRKFSSFFKSLVIELDKELYGPDNHLVEWHRMPTTQETDGFQVKRPGDLNVKCTLLLMLDHQPPQYKLDPRLARLLGVHTQTRAAIMQALWLYIKHNQLQDGHEREYINCNRYFRQIFSCGRLRFSEIPMKLAGLLQHPDPIVINHVISVDPNDQKKTACYDIDVEVDDPLKAQMSNFLASTTNQQEIASLDVKIHETIESINQLKTQRDFMLSFSTDPQDFIQEWLRSQRRDLKIITDVIGNPEEERRAAFYHQPWAQEAVGRHIFAKVQQRRQELEQVLGIRLT
Protein: Chloride channel protein CLC-a (AtCLC-a) (CBS domain-containing protein CBSCLC5) (P92941)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Voltage-gated chloride channel that could play a role in the regulation of nitrate content.
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Chloride channel protein CLC-e
- High affinity nitrate transporter 2.7
- Protein NRT1/ PTR FAMILY 7.2
- Protein NRT1/ PTR FAMILY 6.3
- Protein NRT1/ PTR FAMILY 2.13
- Protein NRT1/ PTR FAMILY 7.3
- Protein NRT1/ PTR FAMILY 6.2
- Protein NRT1/ PTR FAMILY 2.9
- Aluminum-activated malate transporter 12
- High affinity nitrate transporter 2.4
Sequence:
MDEDGNLQISNSNYNGEEEGEDPENNTLNQPLLKRHRTLSSTPLALVGAKVSHIESLDYEINENDLFKHDWRSRSKAQVFQYIFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGYYIAQDRFWTGLMVFTGANLGLTLVATVLVVYFAPTAAGPGIPEIKAYLNGIDTPNMFGFTTMMVKIVGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGPDNHRIKWRWLRYFNNDRDRRDLITCGSASGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLRAFIEICNSGKCGLFGSGGLIMFDVSHVEVRYHAADIIPVTLIGVFGGILGSLYNHLLHKVLRLYNLINQKGKIHKVLLSLGVSLFTSVCLFGLPFLAECKPCDPSIDEICPTNGRSGNFKQFNCPNGYYNDLSTLLLTTNDDAVRNIFSSNTPNEFGMVSLWIFFGLYCILGLITFGIATPSGLFLPIILMGSAYGRMLGTAMGSYTNIDQGLYAVLGAASLMAGSMRMTVSLCVIFLELTNNLLLLPITMFVLLIAKTVGDSFNLSIYEIILHLKGLPFLEANPEPWMRNLTVGELNDAKPPVVTLNGVEKVANIVDVLRNTTHNAFPVLDGADQNTGTELHGLILRAHLVKVLKKRWFLNEKRRTEEWEVREKFTPVELAEREDNFDDVAITSSEMQLYVDLHPLTNTTPYTVVQSMSVAKALVLFRSVGLRHLLVVPKIQASGMSPVIGILTRQDLRAYNILQAFPHLDKHKSGKAR
Protein: Interleukin-1 family member 10 (IL-1F10) (Family of interleukin 1-theta) (FIL1 theta) (Interleukin-1 HY2) (IL-1HY2) (Interleukin-1 theta) (IL-1 theta) (Interleukin-38) (IL-38) (Q8WWZ1)
Organism: Homo sapiens (Human)
Function: Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:32272059}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
Interaction partners:
- Interleukin-1 receptor-like 2
- Interleukin-1 receptor accessory protein-like 1
- Interleukin-1 receptor type 1
- Interleukin-36 beta
- Importin subunit alpha-8
- Interleukin-1 receptor accessory protein
- Interleukin-1 alpha
- Mitogen-activated protein kinase 8
- Importin subunit alpha-7
- Forkhead box protein P1
Sequence:
MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICILPNRGLARTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTKESEPSARTKFYFEQSW
Protein: RE09701p (Q8IGX7)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MANFELGNPKKAARLLSQILESQPTHSAQQTQKYLESRVPGKNVQETKPSWFSNYTRLCQGRRLPEERSGDPLRCYLDGKRHAYFTLAPLQVELVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAGSGGEGTVRDLRVSQQTWLDYKSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEVNLPKNFEGDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKRIGNIWMHSGYQEFRRPCNLTSDSYKSLAYRD
Protein: Insulin-like growth factor 2 receptor (G3V824)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004608}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
Interaction partners:
- Insulin-like growth factor 2
- Insulin-like growth factor 1
- Insulin-2
- Insulin-1
- Cation-dependent mannose-6-phosphate receptor
- Golgi associated, gamma adaptin ear containing, ARF binding protein 1
- Clathrin heavy chain 1
- Clathrin light chain A
- Clathrin light chain B
- AP2-associated protein kinase 1
Sequence:
MRAVLPGPVPSGPRVALLLPLLLLLLVAAAGSAQAQAVDLDALCSYTWEAVDSKNNAVYKINPCGHVDNPRCGPTSAVCMCDLKSENCRSVGDSLLRSSAKSLLEFNTTTGCQPSEHRIQTSITFLCGKTLGTPEFVTATDCVHYFEWRTTAACKKDIFKADKEVPCYVFDDKLQKHDLNPLIKLNGGYLVDDSDADASLFINVCRDIDSLRDPSTQLRVCPAGTAACLLKGNQAFDVGRPKEGLKLLSKDRLVLTYVKEEGEKPDFCNGHSPAVTVTFVCPSERREGTIPKLTAKSNCRYEVEWITEYACHRDYLESETCSLSSEQHDIAIDLSPLAQHEEGSPYVADGGEYRFFMNVCGDTKVSLCNKEAAVCQEKKVDSTQVKIAGRHQNQTLRYSDGDLTLIYSGGDECSSGFQRMSVINFECNKTAGQDGRGEPVFTGEVDCTYFFTWDTKYACVKEKEDLLCGAIDGKKRYDLSVLARHSESEQNWEAVDGSQAESEKRNFFINVCHRVLQAGKAKNCPEGAAVCAVDKSGSKNLGKFVSSPTKEKGHIQLSYSDGDDCGNDKKITTNITFVCKPGDLESAPVLRAAGPDGCSYEFEWHTAAACVLSQTEGENCTVLDAQAGFSFDLSLLTKKNGAYKVETDKYDFYINVCGPVSVNLCQSNSGACQVAKSGKSWNLGLSNTKLTYYDGMIQLSYRNGTLYNNEKHTPRSTLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECMVTDPSMMEQYDLSSLVKFEGGRGGNWYAMENSREHFTRRKYYLNVCRPLNPVPGCDRYASACQMKYENNEGSLAETVAISNLGVAKTGPVVEESGSLLLEYVNGSACTTSDGRLTTYSTRIHLVCGRGTMNSHPIFTFNWECVVSFLWNTEAACPIQTITDSDQACSIRDPNSGFVFNLSPLNYSQGHMVLGIGKTFVFNICGTMPACGTVAGKPALGCEAETKIKDIKDLKPERPVGMEKSLQLSAEGFLTLTYKGSSPSDRGTAFIIRFICNGDIYPGTPKFLHQDIDSARGIRNTFFEFETALACIPSVVDCQVTDPAGNEYDLSALSMVRKPWTAVDTSVHGKKRRFYLSVCTPLPYIPGCDGIAMGSCMVSEDKSQNLGVVQISPQATGNGSLSILYVNGDRCGNQRYSTRIVFECAQTSGSPMFQLLNNCEYVFVWRTVEACPVVREEGDNCQVKDPRHGNLYDLKPLALNDTIISAGEYTYYFRVCGKLSLDVCSAHDGSKAVSSCQEKKGPQGFQKVAGLLNQKLTFENGLLKMNYSGGDTCHKVYQRSTTIYFYCDRTTQKPVFLKETLDCSYLFEWRTQYACPPFNVTECSIQDEAGNSIDLSSLSRYSDNWEAVTRTGATEHYLINVCKSLSPQAGTDPCPPEAAVCLLDGSKPVNLGRVRDGPQWTAGVTVLKYVDGDLCPDKIRKRSTIIRFTCSDSQVNSRPLFISAVQDCEYTFSWPTPAACPVKSNIHDDCQVTNPSTGHLFDLSSLSGKAGITASYSEKGMVFMSICEENVNCSPGVGACFGQTRISVGQASKRLSYKDQVLQLVYENGSPCPSKSGLRYKSVISFVCRPEAGPTNRPMLISLDKQSCTLFFSWHTPLACEQATECTVRNGSSIIDLSPLIHRTGGYEAYDESEDDTSDTTPDFYINICQPLNPMHGVPCPAGASVCKVPVDGPPIDIGRVTGPPIFNPVANEVYLNFESSTPCLADKYMNYTSLIAFHCRRGISMGTPKLIRNNDCDFVFEWETPIVCPDEVKTQGCAVTDEQLLYSFNLTSLSTSTFKVTRDAHTYSIGVCTTAADLDQEGCKDGGVCLLSGSKGASFGRLASMQLDYRHQDEAVILSYVNGDPCPPETEDGEPCVFPFIYKGETYDECVLEGRAKLWCSKTANYDRDHEWGFCRPSNSHRMSAIIFTCDENEDIGRPEVFSEDRGCEVTFEWKTKVVCPPKKMECKFVQKHKTYDLRLLSSLTGSWDFVHEGNSYFINLCQRVYKGPLDCSERASICKKSATGQVQVLGLVHTQKLEVIDETVLVTYSKGHSCGGNKTASSVIELTCAKTVGRPAFKRFDIDSCTYYFYWYSRAACAVRPQEVNMVNGTLTNPVTGKSFSLGEIYFKLFSASGDMRSNGDNYLYEIQLSSISSSSNPACSGANICQVKPNDQHFSRKVGTSDMTKYYVQDGDLDVVFTSSSTCGKDKTKSVSSTIFFHCDPLLKDGVPEFSHETADCQYLFSWYTSAVCPLGVDFDDENAVPEYKGLSERSQAVGAVLSLLLVALTGCLLALLLHKKERRETVINKLTNCCRRSSGVSYKYSKVSKEEETDENETEWLMEEIQVPAARLGKDGQENGHITTKTVKAEALTSLHGDDQDSEDEVLTIPEVKVHTGRGAEVESSQPLRNPQRKVLKEREGERMGLVRGEKARRGKFRPGQRKPTTPAKLVSFHDDSDEDLLHI
Protein: Fibronectin type-III domain-containing protein (G5EF89)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MIETGSQYLLFLLFICSLFNSGSTALQHEDRVPNAPQNVRIKTQSTSATLWWDAPPDPTVLIRGYTVEYGEGSISQRILIEGPDSTSFTVTRLSPNTNYVFAVSAYNEAEGEDGTKVMVAAKTRPSEGSQTEKLWPPTSVRARIDEKSAAGSAFVSWDDPNPESSSENSIDSTQKQYVINYGIYESDTQQKVRSNAKAVRLTGLIPGKEYEVAVKVVAGDGRESPWSIRDLFLVPETKTVSKFDWFCRLNDTEMCSIHSSPHWKLCSEKHDTYTQRDAGACPRVQYPSSPAHLTTPAINLPDAQRLCLYFRFALLNFHPGQMKVEIFRDGDMANKQIVWKTRMANVRTHVVQNVYVPFSQQIKPFKVSVSLKWDGQPMPRVIVHEMDVLSGGCSERSTDSETEVDLLAPVKASLNADARVFRAKGIESLPAIGLQRGVEIAVPYRLYLPRNFFKQFSLLATIKPMDKRGGYLFAAVNAYDSAVDIGLLIEPAGTKQTNISLIVRSVAIVSFLVEDFSQQWTQFALEVVDQTVTFYFKCRRFASRQVTSLPDFSFDEAEKLYIASAGPIIDNGFEGAIQELKLIDDATQGSRQCDEQWGAEGSGTPEEFKKTQESSELQKISDFPPTPAPPPPYPTPQLAPHDLRSYEQQAATTPFQGAPPSNQCTQVCRGEPGPQGPSGNDGIPGSHGAPGHQGERGADGAPGLHGSRGDQGLPGPPGMPGLAGPPGPPGSGTGHGSGADGPQGPPGLPGAPGRDGTSGVEGQRGPQGPPGPKGDDGVSMESLTDDDIERIARRVASIQKESNEPMRGDLPEYNSKVHSFTTKGEKGERGAPGAPGAPAPPAYGTLTTGTAVNVHATTVELFASARSTSVGQLAFATSSQQLFIRVTNGWKEIQLTHFHPFVETRHSTQNSRQNDASHAGRSRTGSAAAPWYPKANLDEPQRDAGVHNKDRVIHMIALSQPFSGNLHGLRGADLQCYREARAAGYTTTFRAMLSSNVQDLVRIVHSVDFDTTVVNVAGHHLFPSWRSFVNGAQMNPHAKLFSFDRHDVLNDSRWPDKRVWHGSKDGGIRAEQYCDGWRRADSSLTSLAGHISSNTSIFQSSGSEKCENKLVVLCVENMSKYHGDRILRLHRITSDFKK
Protein: MHC class I polypeptide-related sequence B (MIC-B) (Q29980)
Organism: Homo sapiens (Human)
Function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q29983}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29983}. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q29983, ECO:0000269|PubMed:12782710}.
Interaction partners:
- NKG2-D type II integral membrane protein
- UL16-binding protein 1
- UL16-binding protein 2
- Hematopoietic cell signal transducer
- Natural cytotoxicity triggering receptor 1
- Natural cytotoxicity triggering receptor 3
- NKG2-A/NKG2-B type II integral membrane protein
- Natural cytotoxicity triggering receptor 2
- MHC class I polypeptide-related sequence A
- Natural killer cells antigen CD94
Sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
Protein: Zeaxanthin epoxidase, chloroplastic (AtZEP) (EC 1.14.15.21) (Protein ABA DEFICIENT 1) (AtABA1) (Protein IMPAIRED IN BABA-INDUCED STERILITY 3) (Protein LOW EXPRESSION OF OSMOTIC STRESS-RESPONSIVE GENES 6) (Protein NON-PHOTOCHEMICAL QUENCHING 2) (Q9FGC7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Zeaxanthin epoxidase that plays an important role in the xanthophyll cycle and abscisic acid (ABA) biosynthesis. Converts zeaxanthin into antheraxanthin and subsequently violaxanthin. Required for resistance to osmotic and drought stresses, ABA-dependent stomatal closure, seed development and dormancy, modulation of defense gene expression and disease resistance and non-photochemical quencing (NPQ). Through its role in ABA biosynthesis, regulates the expression of stress-responsive genes such as RD29A during osmotic stress and is required for normal plant growth during vegetative development. Is required for late skotomorphogenic growth through its role in the xanthophyll carotenoids neoxanthin, violaxanthin and antheraxanthin biosynthesis. Required for beta-aminobutyric acid (BABA)-induced priming in disease resistance, tolerance to salt and drought stresses and sterility. Participates in NPQ by regulating the level of zeaxanthin in photosynthetic energy conversion. NPQ is a process that maintains the balance between dissipation and utilization of light energy to minimize the generation of oxidizing molecules and the molecular damages they can generate.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
- Violaxanthin de-epoxidase, chloroplastic
- Protein LUTEIN DEFICIENT 5, chloroplastic
- Beta-carotene 3-hydroxylase 2, chloroplastic
- Phytoene synthase 1, chloroplastic
- Beta-carotene 3-hydroxylase 1, chloroplastic
- Lycopene beta cyclase, chloroplastic
- Zeta-carotene desaturase, chloroplastic/chromoplastic
- 15-cis-phytoene desaturase, chloroplastic/chromoplastic
- Prolycopene isomerase, chloroplastic
- 15-cis-zeta-carotene isomerase, chloroplastic
Sequence:
MGSTPFCYSINPSPSKLDFTRTHVFSPVSKQFYLDLSSFSGKPGGVSGFRSRRALLGVKAATALVEKEEKREAVTEKKKKSRVLVAGGGIGGLVFALAAKKKGFDVLVFEKDLSAIRGEGKYRGPIQIQSNALAALEAIDIEVAEQVMEAGCITGDRINGLVDGISGTWYVKFDTFTPAASRGLPVTRVISRMTLQQILARAVGEDVIRNESNVVDFEDSGDKVTVVLENGQRYEGDLLVGADGIWSKVRNNLFGRSEATYSGYTCYTGIADFIPADIESVGYRVFLGHKQYFVSSDVGGGKMQWYAFHEEPAGGADAPNGMKKRLFEIFDGWCDNVLDLLHATEEEAILRRDIYDRSPGFTWGKGRVTLLGDSIHAMQPNMGQGGCMAIEDSFQLALELDEAWKQSVETTTPVDVVSSLKRYEESRRLRVAIIHAMARMAAIMASTYKAYLGVGLGPLSFLTKFRVPHPGRVGGRFFVDIAMPSMLDWVLGGNSEKLQGRPPSCRLTDKADDRLREWFEDDDALERTIKGEWYLIPHGDDCCVSETLCLTKDEDQPCIVGSEPDQDFPGMRIVIPSSQVSKMHARVIYKDGAFFLMDLRSEHGTYVTDNEGRRYRATPNFPARFRSSDIIEFGSDKKAAFRVKVIRKTPKSTRKNESNNDKLLQTA
Protein: Phospholipase D gamma 2 (AtPLDgamma2) (PLD gamma 2) (EC 3.1.4.4) (Q9T051)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence. Can use phosphatidylserine but prefers ethanolamine-containing lipids as substrates. Can use phosphatidylcholine (PC) as substrates in the presence of phosphatidylethanolamine (PE) and PIP2. Involved in membrane lipid modulation under aluminum (Al) stress and negatively modulate plant tolerance to Al.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10198096}. Membrane {ECO:0000269|PubMed:10198096}; Peripheral membrane protein {ECO:0000269|PubMed:10198096}. Note=Found mainly associated with intracellular membranes but also with mitochondrial membranes, nuclei and clathrin-coated vesicles. Not found in chloroplast.
Interaction partners:
- CDP-diacylglycerol--serine O-phosphatidyltransferase 1
- Phosphatidyl-N-methylethanolamine N-methyltransferase
- Non-specific phospholipase C1
- Non-specific phospholipase C6
- Non-specific phospholipase C2
- Non-specific phospholipase C5
- Non-specific phospholipase C4
- Phosphatidylserine decarboxylase proenzyme 2
- Phosphatidylserine decarboxylase proenzyme 3
- Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
Sequence:
MSMGGGSNHEFGQWLDQQLVPLATSSGSLMVELLHGNLDIWVKEAKHLPNMICYRNKLVGGISFSELGRRIRKVDGEKSSKFTSDPYVTVSISGAVIGRTFVISNSENPVWMQHFDVPVAHSAAEVHFVVKDNDPIGSKIIGVVGIPTKQLCSGNRIEGLFPILNSSGKPCRKGAMLSLSIQYTPMERMRLYQKGVGSGVECVGVPGTYFPLRKGGRVTLYQDAHVDDGTLPSVHLDGGIQYRHGKCWEDMADAIRRARRLIYITGWSVFHPVRLVRRNNDPTEGTLGELLKVKSQEGVRVLVLVWDDPTSMSFPGFSTKGLMNTSDEETRRFFKHSSVQVLLCPRYGGKGHSFIKKSEVETIYTHHQKTMIVDAEAAQNRRKIVAFVGGLDLCNGRFDTPKHSLFGTLKTLHKDDFHNPNFVTTEDVGPREPWHDLHSKIDGPAAYDVLANFEERWMASKPRGIGKGRTSFDDSLLRINRIPDIMGLSEASSANDNDPESWHVQVFRSIDSTSVKGFPKDPEEATGRNLLCGKNILIDMSIHAAYVKAIRSAQHFIYIENQYFLGSSFNWDSNKDLGANNLIPMEIALKIANKIRARENFAAYIVIPMWPEGAPTSKPIQRILYWQHKTMQMMYQTIYKALLEVGLDGQLEPQDFLNFFCLGNREVGTREVPDGTVNVYNCPRKPPQPNAAQVQALKSRRFMIYVHSKGMVVDDEFVLIGSANINQRSLEGTRDTEIAMGGYQPHHSWAKKGSRPRGQIFGYRMSLWAEHLGFLEQEFEEPENMECVRRVRQLSELNWGQYAAEEVTEMSGHLLKYPVQVDKTGKVSSLPGCETFPDLGGKIIGSFLTLQENLTI
Protein: Prolactin-1 (Prolactin I) (PRL-I) (P69130)
Organism: Oncorhynchus keta (Chum salmon) (Salmo keta)
Subcellular location: Secreted.
Interaction partners:
Sequence:
MARRSQGTKLHLAVLCLVVSCHAIGLSDLMERASQRSDKLHSLSTSLTKDLDSHFPPMGRVMMPRPSMCHTSSLQTPKDKEQALKVSENELISLARYLLLAWNDPLLLLSSEAPTLPHTPSNGDISSKIRELQDYSKSLGDGLDIMVNKMGPSSQYISSIPFKGGDLGNDKTSRLINFHFLMSCFRRDSHKIDSFLKVLRCRATNMRPETC
Protein: Solute carrier family 37 member 4 (A0A0G2JTY3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Interaction partners:
Sequence:
MAITALSYSQPCSEATAFTTSTAKPSLLSCPPWWMRSLWTRTIWVSCSLLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVTAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGSLCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSVYGNPRHSLLLLMMAGMAASMFLFRVTVTSDSPKEAFWTPALHPLAELTGFTEHEIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICIASTVVFFLLRNIRTKMGRVSKKAE
Protein: Putative SERF-like protein (Q9VEW2)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Protein CDV3 homolog
- GM14292p
- UPF0184 protein CG14818
- LD45254p
- GEO09647p1
Sequence:
MTRGNQRDLARQKNQKKQADLTKGKRTDNLTVEQRKARDAELMREKQKKKEEAAAAGTSK
Protein: Zinc finger protein 513a (R4GDS0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Activating signal cointegrator 1 complex subunit 3
- PRP3 pre-mRNA-processing factor 3 homolog
Sequence:
MPRRKQQNPQPVKLDSEDGVGTVRPTNLTFESDFLLGQELEFSDPDNDQKIIGLEKFSADISLPGFPLGDEENSPFSRLSMESDADDLRATESEREERVSESAFPSYLSCRGCGQLLEDPLGPGMDLVGPYCMRCCKGNVEGIVDRKLCSGLGLQAESRGGGNEGTGEDGSLKLHSCTLCGFTSRYTNHVKRHMKTHNGEKPYGCPLCSYASAQLVNLQRHLRIHTGEKPYKCNTCTFACSSLGNLKRHQRMHATIGPGQSVTQPVSGNGLNHSTAAQKEKEAVPAPTEVAGAVRSVTRPHMGRDGNYLQTFDGLRLAQQTSTGVLQSGQAASQPAALPPMFFPFTCRLCGMALDDEDGSSAQICAKCTLEMLTKDTHGCPAERGDKVYTCAACPFLTHYPNHLARHMKTHSGEKPYKCPQCDYASAHFDNLKRHHRVHTGEKPYKCHLCDYACGNLANLKRHQRVHSGAKPFQCAICNYSCNQSMNLKRHMLRHTGEKPHKCQECGYTTGHWDNYKRHQKKHSLAGDGWVKVPLPGNEEEVEDDEEV