wanglab/gogpt-training-data huggingface dataset:
Protein: Myelin regulatory factor homolog 1 (EC 3.4.-.-) (Polyglutamine-repeat protein 47) [Cleaved into: Myelin regulatory factor homolog 1, N-terminal; Myelin regulatory factor homolog 1, C-terminal] (G5EFI7)
Organism: Caenorhabditis elegans
Function: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 1, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation.
Subcellular location: [Myelin regulatory factor homolog 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28441531}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:33950834}. Apical cell membrane {ECO:0000269|PubMed:33950834}; Single-pass membrane protein {ECO:0000255}. Note=In early L1 larvae, localizes to the cell membrane of the pharynx, epidermis, and neurons, but is not enriched in the nucleus or cytoplasm of these cell types (PubMed:33950834). Later in the L1 larval stage, accumulates in the nucleus of the pharynx, epidermis, and neurons (PubMed:33950834). {ECO:0000269|PubMed:33950834}.; SUBCELLULAR LOCATION: [Myelin regulatory factor homolog 1, N-terminal]: Endoplasmic reticulum membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:28441531}. Cytoplasm {ECO:0000269|PubMed:28441531}. Apical cell membrane {ECO:0000269|PubMed:33950834}. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage (PubMed:28441531). In early L1 larvae, localizes to the cell membrane of the pharynx, epidermis, and neurons, but is not enriched in the nucleus or cytoplasm of these cell types (PubMed:33950834). Cell membrane localization is promoted by pan-1 (PubMed:33950834). Later in the L1 larval stage, accumulates in the nucleus of the pharynx, epidermis, and neurons (PubMed:33950834). {ECO:0000269|PubMed:28441531, ECO:0000269|PubMed:33950834}.; SUBCELLULAR LOCATION: [Myelin regulatory factor homolog 1, C-terminal]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28441531}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MSSSDLLKGEFDGLNSEHFNMMQYLTQDTDEDDGSMVSPTSSADSMHQNLGVQQQQQQMLQAQQRQNQNGIFQPRRFPESPAMTDPCGNVSSSSSSSHHSDPMFSPNEFNGYAGANDNGNQTMNNIQSQQLSQQQHQQTRGGNLMMPQQSSIHAQMQNMNAPQFWSQPGTAAVNQPTNTLAQLNLFNIIRGGADSGMPSPVLEMPRKRSRLDTPCETPRIAPSFAGIDGFPDENYSQQQAIRFSKFQEEQWSPLYDINAQPLQQLQVHVVADKGFNYNSNDNCFVNQKKNHFQISVNVEASDTMPPKYVNFNNRLVPIRDFKLSFCGVKAEMPSSEITIRQSRADRKPHTHTPVLFEIQERRMTKVCVPRLHFSETTLNNQRKQKNRPNPEQKFFLLVVRLFASIDESEHGVLIQSYASEKVIVRATNPGSFEPQDTDIGWQRNGGALYTQGAVSVGTEHQVESAKLTVAGDIYMSGRIINPSDIRLKEAITERETAEAIENLLKLRVVDYRYKPEVADIWGLDEQQRHRTGLIAQELQAVLPDAVRDIGDYLTIDEGRVFYETVMATQQLCRMTGDLDSKIDEKVAEISRRLNEYAVRKKLASSMASNLNGDNKSLSYSRCSLTSTATNATSQPKRSRKHRAIKQAQSCGSRLSQGTVVTLVSIMAACLLAMSALYVLDWHNRNYGYHQHFETNTPSTKGELANLVISPANFMPSFQPDAPILLEKCFNPSCKTYCCTDTPPVVEDSRAIATHGLDNGDEVYPESPSNRTNGIARAPNLEHMAFETGVEIRIPALNVTLDQRYCVERSCNKRKGIFNVFVPVSRYMPDVALEIEIKAPISKVVSNCGAFPSTEFNHKVCPLSRTQQSESPVPTSTRLFDNIFELSMGSFIQSAYRFRVGYSTETCFSEDSNGSYEEYNLIFYRMCTLSSS
Protein: Polypeptide N-acetylgalactosaminyltransferase 3 (pp-GaNTase 3) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3) (Q9Y117)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers EA2 as substrate. Has weak activity toward Muc5AC-3, -13 and -3/13 substrates. Plays a critical role in the regulation of integrin-mediated cell adhesion during wing development by influencing, via glycosylation, the secretion and localization of the integrin ligand Tig to the basal cell layer interface. Might have a role in protein O-glycosylation in the Golgi and thereby in establishing and/or maintaining a proper secretory apparatus structure. Together with Pgant35A, regulates integrin levels and activity-dependent integrin signaling at the synapse in neurons and muscles.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:20371600}; Single-pass type II membrane protein {ECO:0000269|PubMed:20371600}.
Interaction partners:
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- FI23944p1
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Tiggrin
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
- Tetraspanin 42Ep, isoform A
Sequence:
MGLRFQQLKKLWLLYLFLLFFAFFMFAISINLYVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAHYIGKGDIFGNMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRTPECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQYFIMLYTSGLTLGAKDKVNVTERVALRERLQCKPFSWYLENIWPEHFFPAPDRFFGKIIWLDGETECAQAYSKHMKNLPGRALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQSMDMFVITPKGQIMTNDNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCASDSSQLWTYDMDTQQISHRDTKLCLTLKAATNSRLQKVEKVVLSMECDFKDITQKWGFIPLPWRM
Protein: Ffar3 protein (Q08AU6)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Interaction partners:
Sequence:
MGTSFFLGNYWLFFSVYLLVFLVGLPLNVMALVVFVGKLRRRPVAVDLLLLNLTISDLLLLLFLPFRMVEAACGMRWLLPFIFCPLSGFLFFTTIYLTSLFLTAVSIERFLSVAYPLWYKTRPRLAQAGLVSVVCWFLASAHCSVVYITEYWGNATYSQGTNGTCYLEFREDQLAILLPVRLEMAVVLFMVPLCITSYCYSRLVWILSRGASRRRRKRIMGLLAATLLIFFVCFGPYNMSHVVGYVSRESPSWRSYVLLLSTLNSCIDPLVFYFSSSKFQADFHQLLGRLLRTCVPWTQQVSLELKVKNGEEPSKECPS
Protein: Chlorophenol reductase (Ortho-chlorophenol reductive dehalogenase) (Q8GFE2)
Organism: Desulfitobacterium hafniense (Desulfitobacterium frappieri)
Function: Reductive dechlorination of ortho-chlorophenols. Dechlorinates in the ortho position with respect to the hydroxyl group.
Subcellular location: Secreted {ECO:0000269|PubMed:12697029}. Secreted, cell wall {ECO:0000269|PubMed:12697029}. Cell membrane {ECO:0000269|PubMed:12697029}. Note=Associated with the cell membrane. Probably binds to peptidoglycans of the cell membrane and cell wall.
Interaction partners:
Sequence:
MKKTLGIILSISLAFSVLALPIFAAVDTTTSATVEAATPAAPATPAATAPAAAPSVDTSKIAAGTYYTVVSGDFFWQIAAKHGLTIDALAKLNPQIKNVNLIFPGQKILVKAEEAAAASTSTSTAAVAPAAKKLYQGIGMAANYRDNTARQKDHDNLNITTVAALFDDAGKIVKLQFDVVEILPDMFPGWMDPEAADKSFYKDAQANGFNWETKKEEGDAYGMKASAVSGKEWWEQMNFYEEYFKGKTVAEVQDWFAKYCDANGRPYKMAYPEKLTDADKAKVATFTEAEKKMLVDVTTGATMSLQDPHSRFIDALVKAYEVRKEVK
Protein: Protein kinase superfamily protein (F4IQ85)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MDRDFHRRGQVVNQDQRATNSNVFTKFENTYLQITAHLCVLVKTQANDRTQSNFVRLDKPRAVDDLDIGKRGKMRRWLCCSCRVQESYPSAENNRLKTPPTRHYDYGRNNKKTPAPVKPPVLKEPPPIDVPAMSLVELKEKTQNFGSKALIGEGSYGRVYYANFNDGKAVAVKKLDNASEPETNVEFLTQVSKVSRLKSDNFVQLLGYCVEGNLRVLAYEFATMRSLHDILHGRKGVQGAQPGPTLEWMQRVRVAVDAAKGLEYLHEKVQPAVIHRDIRSSNVLIFEDFKAKIADFNLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLVTWATPRLSEDKVKQCVDPKLKGEYPPKAVAKLAAVAALCVQYEAEFRPNMSIVVKALQPLLRSATAAAPPTPQP
Protein: Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (P97305)
Organism: Mus musculus (Mouse)
Function: Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (By similarity). Along with NFATC4, involved in embryonic heart development.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21525433, ECO:0000269|PubMed:24970700}. Nucleus {ECO:0000269|PubMed:20495147, ECO:0000269|PubMed:21514407, ECO:0000269|PubMed:21525433, ECO:0000269|PubMed:24970700, ECO:0000269|PubMed:25215946}. Note=The subcellular localization of NFATC plays a key role in the regulation of gene transcription (Probable). Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals (Probable). Cytoplasmic when phosphorylated and nuclear after activation, that is controlled by calcineurin-mediated dephosphorylation (Probable). Translocation to the nucleus is increased in the presence of calcium in pre-osteoblasts (PubMed:21514407). Translocates to the nucleus in the presence of EDN1 following colocalization with F-actin filaments, translocation is ROCK-dependent (PubMed:20495147, PubMed:21525433). Translocates to the nucleus in response to lipopolysaccharide treatment of macrophages (PubMed:24970700). {ECO:0000269|PubMed:20495147, ECO:0000269|PubMed:21514407, ECO:0000269|PubMed:21525433, ECO:0000269|PubMed:24970700, ECO:0000305|PubMed:10089876}.
Interaction partners:
- Stress-activated protein kinase JNK
- Calcineurin subunit B type 1
- Mitogen-activated protein kinase 10
- Protein phosphatase 3 catalytic subunit alpha
- Mitogen-activated protein kinase 9
- Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
- Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
- Transcription factor GATA-4
- Glycogen synthase kinase-3 beta
- Myocyte-specific enhancer factor 2C
Sequence:
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQFTSISPNCQQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGSGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSEDQAAILPGKLEICSDDQGNLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGGPHWEVEGKIIREKCQGAHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLPSVPSLPVPHSAQAQRPSSETGHPHDRAMSAPGGLLCQVQPAYTSMVASTHLPQLQCRDEGAGKEQHIATSSVMHQPFQVTPTSPIGSSYQSIQTSMYNGPTCLPVNPASSQEFDPVLFQQDAALSSLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSNAGQTALSSPVADQITGQPSSHLQPITYCPSHPGSATAASPAASHPLASSPISGPSSPQLQPMPYQSPSSGTASSPSPTTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGATVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQISVSQATEVMRDTPLPGPASPDLMTSHSAH
Protein: Vesicle-associated protein 1-3 (Plant VAP homolog 13) (AtPVA13) (VAMP-associated protein 1-3) [Cleaved into: Vesicle-associated protein 1-3, N-terminally processed] (Q84WW5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in vesicle trafficking.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- DEAD-box ATP-dependent RNA helicase 39
- CLAVATA3/ESR
- Myb family transcription factor PHL13
- Probable inorganic phosphate transporter 1-7
- Purple acid phosphatase 17
- Clathrin heavy chain 1
- Myb family transcription factor PHL6
Sequence:
MTTGDLVNIHPTELKFPFELKKQSSCSMQLTNKTTTQCVAFKVKTTNPRKYCVRPNTGVVLPGDSCNVTVTMQAQKEAPLDMQCKDKFLVQTVVVSDGTTSKEVLAEMFNKEAGRVIEDFKLRVVYIPANPPSPVPEGSEEGNSPMASLNDIASQSASLFDDVSRTFEETSEKSSEAWSMISKLTEEKTSATQQSQKLRLELEMLRKETSKKQSGGHSLLLMLLVGLLGCVIGYLLNRI
Protein: Collagen triple helix repeat-containing protein 1 (Q8CG08)
Organism: Rattus norvegicus (Rat)
Function: Its overexpression in smooth muscle cell lines increases their migratory ability and inhibits collagen type I expression. May act as a negative regulator of collagen matrix deposition.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15618538}.
Interaction partners:
Sequence:
MHPQGRAASPQLLLGLFLVLLLLLQLSAPSSASENPKVKQKALIRQREVVDLYNGMCLQGPAGVPGRDGSPGANGIPGTPGIPGRDGFKGEKGECLRESFEESWTPNYKQCSWSSLNYGIDLGKIAECTFTKMRSNSALRVLFSGSLRLKCRNACCQRWYFTFNGAECSGPLPIEAIIYLDQGSPELNSTINIHRTSSVEGLCEGIGAGLVDVAIWVGTCSDYPKGDASTGWNSVSRIIIEELPK
Protein: Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2) (P97469)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O43623}. Cytoplasm {ECO:0000250|UniProtKB:O43623}. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions (By similarity). {ECO:0000250|UniProtKB:O43623}.
Interaction partners:
- Lysine-specific histone demethylase 1A
- Paired amphipathic helix protein Sin3a
- Cadherin-1
- Twist-related protein 1
- Cadherin-2
- Catenin beta-1
- Twist-related protein 2
- Transcription factor SOX-9
- Cellular tumor antigen p53
- Vimentin
Sequence:
MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYPIPVIPKPEILTSGAYSPITVWTSSAAPLHSPLPSGLSPLTGYSSSLGRVSPPPSSDTSSKDHSGSESPISDEEERLQPKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH
Protein: Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) (Q86VP6)
Organism: Homo sapiens (Human)
Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21249194}. Nucleus {ECO:0000269|PubMed:21249194}. Note=Predominantly cytoplasmic.
Interaction partners:
- Cullin-1
- E3 ubiquitin-protein ligase RBX1
- Cullin-4B
- Cullin-3
- Cullin-4A
- Cullin-2
- S-phase kinase-associated protein 1
- DCN1-like protein 1
- Ubiquitin-like protein NEDD8
- Cullin-5
Sequence:
MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCMGQIICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEITSQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVAECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKDSSSTNLESMDTS
Protein: DNA damage response protein (Dap1), putative (Q4WXS1)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Subcellular location: Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Interaction partners:
Sequence:
MSIATPINLILLSLFAILVYMQLRPKAPVALPQAPPPVVFRTFTPTTLLEYNGEGDKPVYLAVRGRVFDVTPGKNFYGPGGPYENFAGRDASRGLAHQSFDVEMLTKDLKGPLDDLKDLNEEQLENLQSWEERFLEKYLVVGKLVAEGDPEAPKS
Protein: Nucleosome assembly protein 1-like 1 (B9ELD5)
Organism: Salmo salar (Atlantic salmon)
Interaction partners:
Sequence:
MADMDNKDQAELDPADLEDVEDVEEEETGEDVNSKARQLTVQMMQNPQILAALQERLDGLVGSPSGYMESLPKVVKRRVNALKNLQVKCAHIEAKFYEEVHELERKYAALYQPLFDKRSDIVKAAYEPTEEECEWKADEEEELTVSKQEEMKEKAKVEEEKKDEEKEDPKGIPEFWLTVFKNVDLLSDMLQEHDEPILKHLQDIKVKFSDPGQPMSFSLEFYFEPNEFFTNTLLTKTYKMRSEPDENDPFSFDGPEIMGCTGCTIDWTKGKNITLKTIKKKQKHKGRGTVRTVTKTVPNDSFFNFFTPPDVPESGDLDEDSEAVLAADFEIGHFIRERIVPRAVLYFTGEAIEDDDDDYDEEGEEADDEEGEEEGEEENDPDYDPKKDANPPAECKQQ
Protein: Tyrosine-protein kinase-like otk (Gp160-Dtrk) (Dtrk) (Off-track) (Tyrosine-protein kinase-like 7 homolog) (Q6AWJ9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1371458}; Single-pass type I membrane protein {ECO:0000269|PubMed:1371458}.
Interaction partners:
- Plexin A, isoform A
- Semaphorin-1A
- non-specific serine/threonine protein kinase
- Stretchin-Mlck, isoform U
- Protein Wnt-2
- Protein Wnt-4
- Microtubule-associated protein
- Bent, isoform F
- Myocardin-related transcription factor, isoform H
- Frizzled-2
Sequence:
MTARMISICGLVMALMMASVLASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDKRVHQIGSNLHIEAVRRTEDVGNYVCIATNLASGAREASPPAKLSVIYLESASVQLLGSNRNELLLKCHVEGASGDLEPLEIEWYRNSEKLSTWKNVQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRLPRRKNEKMMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVVAKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHKHRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKAMQSAEK
Protein: Triadin (Q28820)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity).
Subcellular location: Sarcoplasmic reticulum membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:19230141, ECO:0000269|PubMed:19398037, ECO:0000269|PubMed:7685347, ECO:0000269|PubMed:7721813, ECO:0000269|PubMed:8550602}.
Interaction partners:
- Ryanodine receptor 2
- Calsequestrin-2
- Calsequestrin-1
- Ryanodine receptor 1
- Aspartyl beta-hydroxylase/Triadin domain-containing protein
- Ryanodine receptor 3
- Peptidyl-prolyl cis-trans isomerase FKBP1B
- Calmodulin
- Calmodulin 2
- Calmodulin like 5
Sequence:
MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDLVTTFSSPAAWLLVIALIITWSAVAVVMFDLVDYKNFSASSIAKMGSDPLKLVHDAVEETTDWIYGFFSLLSDIISSDGDEEDDEGDEDTAKGEIEEPPLKRKDIHKEKIEKQEKPERKIPTKVVHKEKEKEKEKVKEKEKPEKKATHKEKLEKKEKPETKTVTKEEKKARTKEKIEEKTKKEVKGVKQEKVKQTVAKAKEVQKTPKPKEKESKETAAVSKQEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPSPTEQASRPTPALPTPEEKEGEKKKAEKKVTTETKKKAEKEDAKKKSEKETDIDMKKKEPGKSPDTKPGTVKVTTQAATKKDEKKEDSKKAKKPAEEQPKGKKQEKKEKHEEPAKSTKKEHAAPSEKQAKAKIERKEEVSAASTKKAVPAKKEEKTTKTVEQETRKEKPGKISSVLKDKELTKEKEVKVPASLKEKGSETKKDEKTSKPEPQIKKEEKPGKEVKPKPPQPQIKKEEKPEQDIMKPEKTALHGKPEEKVLKQVKAVTTEKHVKPKPAKKAEHQEKEPPSIKTDKPKSTSKGMPEVTESGKKKIEKSEKEIKVPARRESHQLQNVTKAEKPARGSKEGFEDVPASKKAKEEAEEVSSTKKQKSPISFFQCVYLDGYNGYGFQFPVTPAQYPGESSGKPNSPGPKQ
Protein: UPF0235 protein At5g63440 (Q8GWQ6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role during early embryonic development. Probably involved in pre-mRNA splicing (By similarity).
Subcellular location: Nucleus speckle {ECO:0000269|PubMed:23454656}.
Interaction partners:
- DNA polymerase epsilon subunit B
- Citrate synthase-like protein
- Cysteine proteinase RD21A
- Probable ADP,ATP carrier protein At5g56450
- Casein kinase II subunit alpha-1
- At1g09850
- Citrate synthase 3, peroxisomal
- Probable cysteine protease RD21B
- Mitochondrial succinate-fumarate transporter 1
- Citrate synthase 5, mitochondrial
Sequence:
MPKRTTHTYSSEDAAPDGPDSDLFVYYCKHCGSHVLITDTQLQKMPKRKTDRSNVLDKKTHLARLNVSEGGKVLLKRGEGKMERQFRMNCIGCELFVCYRAEENLETASFIYIVDGALSAVAAETNPQDAPVPPCISQLDGGLVQVAIEVEDRAQRSAITRVNADDVRVTVAAPAARGEANNELLEFMGRVLGLRLSQMTLQRGWNSKSKLLVVEDLSARQVYEKLLEAVVP