wanglab/gogpt-training-data huggingface dataset:
Protein: Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase) (Q9Y463)
Organism: Homo sapiens (Human)
Function: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance. During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).
Subcellular location: Nucleus {ECO:0000269|PubMed:32611815, ECO:0000269|PubMed:33469661}. Nucleus, nucleolus {ECO:0000269|PubMed:33469661}. Chromosome {ECO:0000269|PubMed:32611815}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. {ECO:0000269|PubMed:32611815}.
Interaction partners:
- DDB1- and CUL4-associated factor 7
- Pterin-4-alpha-carbinolamine dehydratase 2
- Protein FAM53C
- Hepatocyte nuclear factor 1-alpha
- E3 ubiquitin-protein ligase RNF169
- Pterin-4-alpha-carbinolamine dehydratase
- Cardiac-enriched FHL2-interacting protein
- Histone acetyltransferase p300
- Retinoblastoma-like protein 2
Sequence:
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS
Protein: DNA polymerase I A, chloroplastic/mitochondrial (EC 2.7.7.7) (DNA polymerase PolI-like B) (AtPolI-like A) (Polymerase gamma 2) (POLGAMMA2) (F4I6M1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity (By similarity). Required for DNA replication and accumulation in plastids and mitochondria. May be required for DNA repair in both organelles.
Subcellular location: Plastid, chloroplast. Mitochondrion. Note=Targeted to chloroplast when translation is initiated at the AUG initiator start, and to mitochondrion when it is initiated at a non-canonical CTG leucine codon located 21-bp upstream of the initiator methionine codon. {ECO:0000269|PubMed:16169894}.
Interaction partners:
- DNA polymerase I B, chloroplastic/mitochondrial
- Probable protein S-acyltransferase 12
- Twinkle homolog protein, chloroplastic/mitochondrial
- Probable protein phosphatase 2C 74
- Primase homolog protein
- Protein DGS1, mitochondrial
- 5'-3' exonuclease family protein
- Formamidopyrimidine-DNA glycosylase
- At4g03260
- DNA repair protein RAD50
Sequence:
MAMGVSLTSHNNPLLRHLSPSSSWVSRSSSRLSSSPLPSFLFPCRRTLLQRKLASTDGNVGYCTTTVCQGFQHSVHQRSSSVVFNGEWELRSESNKVRMVPKIIKVGNQTEVAETHQVPGTVSAWREEANKLRERNGQIARNLDDNGYFNGSVPIISSAPSYETSQKIDYEFKPRGTTRSTTATLNKELIGITQSEPVVSLPRKGLDVGDNMDVNPKGEGIQRPLISDKSSGTANGNKNTVAISKVERSTEPSNVRENLGKIYDKVLIVDNVQAAKDTVAKLVNQFRNHVHSCDTEVSGIEVKEETPVDHGELICFSIYCGPEADFGNGKSCIWVDVLGENGREVLAEFKPYFEDSFIRKVWHNYSFDSHIIRNHGIEISGFHADTMHMARLWDSARRIKGGYSLEALTSDPKVLGGTQTKEEAEFLGKISMKTIFGKRKLKKDGSEGKIVVIPPVEELQREDREAWISYSALDAISTLKLYESMTKKLQLMDWHLDGKPVLGRTMLDFYHEFWRPFGELLVKMEAEGILVDREYLAEIEKVAKAEQQVAGSRFRNWASKYCPDAKYMNIGSDTQLRQLFFGGISNSHDEVLPVEKLFKVPNIDKVIEEGKKTPTKFRNIKLHRISDSPLSTENFTASGWPSVGGDVLKELAGKVSAEYDFMDDVSDISLEEVVEDDDVETSETQKSKTDDETDTSAYGTAYVAFGGGERGKEACHAIASLCEVCSIDSLISNFILPLQGSNVSGKDGRVHCSLNINTETGRLSARRPNLQNQPALEKDRYKIRKAFVASPGNTLVVADYGQLELRILAHLTGCKSMMEAFKAGGDFHSRTAMNMYPHVREAVENGQVILEWHPEPGEDKPPVPLLKDAFGSERRKAKMLNFSIAYGKTAVGLSRDWKVSTKEAQETVDLWYNDRQEVRKWQEMRKKEAIEDGYVLTLLGRSRRFPASKSRAQRNHIQRAAINTPVQGSAADVAMCAMLEISINQQLKKLGWRLLLQIHDEVILEGPIESAEIAKDIVVDCMSKPFNGRNILSVDLSVDAKCAQNWYAAK
Protein: Thyroxine 5'-deiodinase (Q552Y2)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
- Thioredoxin reductase
- Glutathione S-transferase domain-containing protein DDB_G0274223
- Glutathione transferase
Sequence:
MNYLFNIFEEEKPIKKAPIITEECYRNGYHPSKWELAQVLLNGIWKPYKFKSYMQYKSRERLNLQADTQCPDAILLDDQTNQEVSLYDLFNSNNNEKSVQDRPMVLICGSFTUPPFRDKMCMFQDIFVDFKEWVDIYIVYLKEIHPADEWYIGGDEISLCYRQPKTMEDRREIIKDLKEYAPFCTIPFLIDKMDNNFNKVYDAVPERLYVLEDKKFKYVGGPGPFGFIPEELREFLTKRYKPHLLDLKNNLSIPPSQ
Protein: Methyltransferase small domain-containing protein (A0A0H2UQS7)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Interaction partners:
Sequence:
MEEEQLLKSGERINQLFSTDIKIIQNREVFSYSVDSVLLSRFPRFPKKGLIVDFCAGNGAVGLFASTRTQAQILSVEIQERLADMAERSVRLNGLEEQMQVICDDLKNMPAHIQGSKVDMILCNPPYFKVNPYSNLNESEHYLLARHEITTNLEEICRSAQSILKSNGRLAMVHRPDRLLDILDTLKRHNLAPKRLQFVYPKREKEANMLLIEAIKDGSTSGFKVLPPLIVHNDDGSYTPEIEEIYYGS
Protein: Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) (Major surface antigen) (Q76R62)
Organism: Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C)
Function: The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
Subcellular location: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04075}.
Interaction partners:
Sequence:
MGGWSSKPRQGMGTNLSVPNPLGFFPDHQLDPAFGANSNNPDWDFNPNKDHWPEANQVGAGAFGPGFTPPHGGLLGWSPQAQGILTTLPAAPPPASTNRQSGRQPTPISPPLRDSHPQAMQWNSTTFHQALLDPRVRGLYFPAGGSSSGTVNPVPTTASPISSIFSRTGDPAPNMESTTSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGAPTCPGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLLPGTSTTSTGPCRTCTIPAQGTSMFPSCCCTKPSDGNCTCIPIPSSWAFARFLWEWASVRFSWLSLLVPFVQWFVGLSPTVWLSAIWMMWYWGPSLYNILSPFLPLLPIFFCLWVYI
Protein: SD08724p (Q7YU85)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MENNICAIVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVRVLESGVSSNGNGTTGSGDHIEEGTAVQLRDKSATSNRRCKVIYSYTQVNDDELTLAVGDVIEFLGEVEEGWWRGRLRSKVGVFPSNFVQHIEPSPVLASKRPPTIGATVTTSALTSKAVNVANVAATVPTGGAVPPASTSTSTSTTKQATKSRATAAAAASAPAEPAAIVSGSGAAAGGGAAAAVPMLPPKPQREFCRVEFPYAPQNDDELELKVDDIIAVISTELPDKGWWKGEIRGKVGVFPDNFVKMLAPSEVAPINEPPSATQITQNQRKVSNTASTTSHMTTTNSSNSSTTSVTTQQQKEQIGGSSSTTSKVYIKKTGSSSNSTTSSTTTASSSAGRKESFGSRDSLNDILSETGLPTGNVAAQRKSLENKNLDLTKPPGVGASVSIGQQRSSTSSATTSSATTVATGLTSSSVSKSMENMLDEKVKSPPPPVLSKKPSVPLKKTPTGGVPMTGNLLGGKKKNTEGKLTTAVSHDLADGLAASKMLSGANQLPESGAAGNVVIRRAATIAVEDTDFDRVERASILTDMRQGRVKAPKRRPPSAAINVLGESNNNSVYVNGSGMSGSGGAGSASELSEDGGAGGKTSDDNSTGEEPQLAKPKPREWEKKKAPWMEELKASQVTRKKTSPSVEPRGASVAERTSKLFAAEQAVSSNSSSTTTKVQSSAVTSSMFVENSTTSSSVITSSSHTTTNDAIMSRSLSAAKVQTASSDEETRATRPNSLAIRNQRSVSPLVKSSNASSSQSQEEKPTSQLNNHQDASSSRVAQLEQRVDKLEGLVLNQQRTIEELVNALKSEAERVKILRSELDKYAQCVTQV
Protein: Ras guanine nucleotide exchange factor D (RhoGAP domain-containing protein D) (Q8IS19)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Promotes the exchange of Ras-bound GDP by GTP.
Interaction partners:
- Ras-like protein rasD
- Ras-like protein rasG
Sequence:
MGNSKQIKRSLTGSILLKKQISQIFFKKLESIFGIALAEDTSDRLMDYLNKSIDYLLDHSVIEGLFSIEIEESKLKSTIESIESTLITDFSLTTDPCYVASTFILYFSKLPNLLLSKISSQLIHSVEISHEEYRINVIRSLLYSLPLQNRNILKMVLHFLKKFSLACNNNNNNNSENNNTIVEDIEVQSAYNRFTKAFMSTTPGNFEISCKAIRLMVMDIDEFDKLPQDIQYMVKDGESIVKAATFDRLVEKLFDLSYGFKDPDYNYTVFHTYDYYTTSVELLGKIVHYYRIACTLTTKLQMEVSITILSVAMFWMKIHHNHLMTDLQFLQKLKIFLDSVPQVPPTQVTYFTYFQTFFKPVIEPLKPLYERGNSFLGPNLTQSSGTSKKKNQLIEKMMINNNINNNNNINNNVNSNSNNNFNNNIDIDIYNIGSNIIAQQITIIDNEMLMAIPPSQFLHKSFSKESKSPQFHDMVSKFNEWARWTSSEILSKEKLVERVVTLSFFIDLAKSCVELGNYNAANAIVGGLNHSSISRLKLTWERLSTKVTQDYDRLLSLFDLSMNYKNYRDEIKSTKAKIIPYLGLFPKDLIAIEEGNDNFTNNNLINTEKFRLLYQTIKKIQSYQQPLFTFKTSEPIKQYLKNISNGLSEEKDFHSISHKLEPRQQQTQ
Protein: WPP domain-interacting protein 1 (Q8GXA4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips. As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes.
Subcellular location: Nucleus envelope {ECO:0000269|PubMed:17600715, ECO:0000269|PubMed:22270916}. Nucleus membrane {ECO:0000269|PubMed:17600715}; Single-pass membrane protein {ECO:0000269|PubMed:17600715}; Cytoplasmic side {ECO:0000269|PubMed:17600715}. Note=Targeted to the nuclear envelope (NE) during interphase. Associated to the cell plate during cytokinesis in root tips.
Interaction partners:
- Nuclear-pore anchor
- Nuclear pore complex protein NUP155
- Amino-terminal region of chorein
- Ubiquitin-like-specific protease ESD4
- Paired amphipathic helix protein Sin3-like 4
Sequence:
MDLESESSALESVDDNVLIQQSASNVCDDGRSLDNGSCSDESVKLLSTSNSVELGKPMSFDSPGDGGGAYSPVLKGQGLRKWRRIRRDLVKDTSANMENSKALKRGLSGVAHSHGKQMQFQSPEVEQESQGSVGSVNMLKSSGDGFDILGSSGYDSRFVAGVGFSAGMDLEIDDDRSSKSSTVARAPKVIRYEKPMISSGQGGNIRVENSKKHRGESVDFEKENSYSSLESDSRKQSGRMMDYNGENGETSMRKDDAGGEGGESINTDNRYSDEMDPLTEAINGFLALQDALEKEVQQFQEIGNEPMPQHHEQVSEANSPHPEIVTLVNNVEQLENMLEETRSMLEVKESHIRDLESTTNQSKHSWGGTEIVVEDIFRQKIEAEIEYLIYSRSIDNLNSQMKLIDEQESLAEEQTHETLNKLGRVQTKAANFTNRAQDLQNDCIEITGTIKKRACKITSYVLIQLVLLSTVVLLLLSQLLPEPDTVVPT
Protein: Apolipoprotein D (Apo-D) (ApoD) (P05090)
Organism: Homo sapiens (Human)
Function: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
Subcellular location: Secreted.
Interaction partners:
- Apolipoprotein A-II
- Apolipoprotein A-I
- Clusterin
- Apolipoprotein E
- Lipocalin-1
- Apolipoprotein B-100
- Apolipoprotein A-IV
- Phosphatidylcholine-sterol acyltransferase
- Apolipoprotein C-I
- Apolipoprotein F
Sequence:
MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTFENGRCIQANYSLMENGKIKVLNQELRADGTVNQIEGEATPVNLTEPAKLEVKFSWFMPSAPYWILATDYENYALVYSCTCIIQLFHVDFAWILARNPNLPPETVDSLKNILTSNNIDVKKMTVTDQVNCPKLS
Protein: Histone deacetylase 7 (C9JNI4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKT
Protein: SH3 domain-binding protein 5-like (SH3BP-5-like) (Q7L8J4)
Organism: Homo sapiens (Human)
Function: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
Interaction partners:
- Ras-related protein Rab-11B
- Ras-related protein Rab-11A
Sequence:
MAELRQVPGGRETPQGELRPEVVEDEVPRSPVAEEPGGGGSSSSEAKLSPREEEELDPRIQEELEHLNQASEEINQVELQLDEARTTYRRILQESARKLNTQGSHLGSCIEKARPYYEARRLAKEAQQETQKAALRYERAVSMHNAAREMVFVAEQGVMADKNRLDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLCQQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVALRNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGSSLGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDGGARGGRHQRSVSL
Protein: Proteasome chaperone 4 (Q12245)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in 20S proteasome assembly, facilitating the alpha-ring formation. Involved in maintenance of telomere length.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Proteasome chaperone 3
- Proteasome subunit alpha type-5
- Proteasome chaperone 1
- Proteasome assembly chaperone 2
- Proteasome maturation factor UMP1
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-4
- 26S proteasome regulatory subunit RPN10
- Proteasome activator BLM10
- Protein RPN4
Sequence:
MLVKTISRTIESESGFLQPTLDVIATLPADDRSKKIPISLVVGFKQEASLNSSSSLSCYYYAIPLMRDRHINLKSGGSNVVGIPLLDTKDDRIRDMARHMATIISERFNRPCYVTWSSLPSEDPSMLVANHLYILKKCLDLLKTELGE
Protein: IP07950p (Mitochondrial translation initiation factor 3, isoform A) (Mitochondrial translation initiation factor 3, isoform B) (Q4V619)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MQRIRLMFNHAAAAAIQQQHLRPLTVYWSLAQHQKPVGGSPGDSRTRDTRSLKASVQKITLIQQNQSISITTLEEAQKLAKRRDLHLLRLEQTDAKTGRAMFKLVTAAEMLSDDAEQSRSASEKVKDKKTEKSLTIGARITEHDLSSRLKNIVKWLGKRHEVRILIQGNASGSDESSAERIVKAIEQTIKEPQLIGRIVQRRSKSAFIKFSIIPVAPPPVPASTATSNTIQS
Protein: Probable UMP-CMP kinase 2 (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Q6NMK6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03172}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03172}.
Interaction partners:
- Uridine 5'-monophosphate synthase
- UMP kinase
- Nucleoside diphosphate kinase 1
- Nucleoside diphosphate kinase II, chloroplastic
- Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
- Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
- Ribonucleoside-diphosphate reductase small chain A
- Ribonucleoside-diphosphate reductase small chain C
- Ribonucleoside-diphosphate reductase large subunit
- Uracil phosphoribosyltransferase, chloroplastic
Sequence:
MWRRVALLSPMISSSSRSLKLSQAASGLKVGESFATDIISQEERVSPPKEKAPFITFVLGGPGSGKGTQCEKIVETFGLQHLSAGDLLRREIAMHTENGAMILNLIKDGKIVPSEVTVKLIQKELESSDNRKFLIDGFPRTEENRVAFERIIRADPDVVLFFDCPEEEMVKRVLNRNQGRIDDNITTMKKRLKIFNALNRPVIDYYKNKGKLYTINAVGTVDDIFQHVLPIFNSFEQLKESSHVNPQSHLGSSLVENSS
Protein: Cephalotocin receptor 2 (Q5WA50)
Organism: Octopus vulgaris (Common octopus)
Function: Acts as a receptor for cephalotocin.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
Sequence:
MYQAMEVESTSPSGFFLDFYTQSTIPTTDFLNNTNSSHPIRDEKLVKIEIAVLGTCFTLAIINNLCVLLVLLWRRKKVRRMQMFILHLSIADLIVAFFNILPQLIWDITFRFMAGDAMCRFIKYAQMFSLYLSTYILIMTAVDRYRAICHPLSNQTWTPCMVYCKIFIAYAIATIFSIPQAILFQMQEVNEGSGIYDCWVHFEPAWVLTAYALYIFFALYLIPILILFFTYGSICYTIWAKYRHAIKTKKDANTRYPQRRKKKGVILRTHSVHGFSKAKLNSVKLTFAVIVTYIICWSPFFVSQIWWLFDETVVGNAGVVVILLMACLNSCTNPWIYLIFNRNYISNVLPCKCLRRHRVEVAATTETERLSLGSVRRDSRKTSDPKRISESRRISDARRISGKTQKNNSSSPRKTSDQFIYSDKTT
Protein: NADPH oxidase 1 (NOX-1) (EC 1.6.3.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1) (Q9Y5S8)
Organism: Homo sapiens (Human)
Function: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.
Subcellular location: Cell projection, invadopodium membrane {ECO:0000269|PubMed:19755710}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:26301257}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- NADPH oxidase activator 1
- Neutrophil cytosol factor 2
- Neutrophil cytosol factor 4
- Cytochrome b-245 light chain
- NADPH oxidase organizer 1
- Neutrophil cytosol factor 1
- NADPH oxidase 2
- NADPH oxidase 4
- Dual oxidase 1
- NADPH oxidase 3
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
Protein: Uncharacterized protein (Q586F1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- DUF1663 domain-containing protein
Sequence:
MSRISTLPADIREAGMSKSHVVTSRAASPRCAKCLDQSMSRISMMPADVREAGMSKSHVVTSRAASPRCAKCLDQSMSRISTLPADIREAGMSKSHVVTSRAASPRCAKCLDQSMSHISMVPADVREAGMSKSHVVTSRAASPRCAKCLDQSMSRSSTLPADVREAGMSKSEVEPSLAASLRCAKCLDQSMSRSSTLPDDVREAGMSKSEVEPSLAASSRCAKCLDQSMSVGSDFVSVLLVGGVNEVGNDRSGFQRKRYPVSWHKHCDGPSPLRSLCDDGATFWKVPRKVSEDPEDNMSTAHSISTSVSDPVSPSAVNVVVKYSGAENICVGASTDGEMKAMPHTMLLDGEVWEYIYLRKSSELRDAFASDIGDVLGFPFSTPIEFTPTRTGILAHCTLLYPETMKTEELYERLSRDKFPAMRRLYQTAKREQMITSCSTMYTTNICDRPISPPPEDMDGRRGSMQMMSSATSTNHKPEEYCLSKREERRDATKEDATGMDTESQEIHYSRFTERSMSRISMVPADVREAGMSKSEVEPSLAASLRCAKCLDQSMSHISMMPADVREAGMSKSEVEPSLAASLRCAKCLDQSMSRISMMPADVREAGMSQSQIGTLPATIPVYCPQLLERCMSCASTILADVREAGMSQSQIGTLPASIPVYCPQLLERCMSCASTILADVREAGMSQSQIGTLPATIPVYCPQLLERCMSCASTILADVREAGMSQSQIGTLPATIPVYCPQLLERCMSCASTILADVREAGMSKSEVEPSLAASPRCAKCLDQSMSRISMMPADVREAGMSKSEVEPSLAASLRCGKCLDQSMSRISMMPADIREAGMSKSEVEPSLAASLKYGKCLDQSMSRISMMPADVREAGMSKSEVEPSLAASLRCGKCLDQSMSRISMMPADIREAGMSKSEVEPSLAASLRCGKCLDQSMSRISMMPADVREAGMSKSEVEPSLAASLRCGKCLDQSMSRISMMPADVREAGMSKSEVEPSLAASLRCAKCLDQSMSRISMMPADIREAGMSKSEVEPSLAASLKYGKCLDQSMSRISMMPADVREAGMSKSEVEPSLAASLRCAKCLDQSMSRISMMPADIREAGMSKSEVEPSLAASLKYGKCLDQSMSRISMMPADIREAGMSRSEVEPSLAASLKYGKCLDQSMSRISMMPADVREAGMSKSEVEPSLAASLKYGKCLDQSMSRISMMPADIREAGMSRSEVEPSLAASLKCGKCLDQSMSRISMMPADVREAGMSKSEVEPSLAASLKYGKCLDQSMSRISMMPADIREAGMSRSEVEPSLAASLKCGKCLDQSMSRISMMPADVREAGMSKSEVEPSLAASLKYGKCLDQSMSRISMMPADVREAGMSKSEVEPSLAASLKCGKCLDQSMSRISMMPADVREAGMSKSEVEPSLAASLKYGKCLDQSMSRISMMPADVREAGMCKRGEAESLVVSSNSREVNGGVKNLSSGNSSASLDGRKFVCSSGKSGDYSASFGDGGCCQIVGGAEAGGVVVLEEFRDIPSGAGSNLPVPVDEVPGGGVRMSSDVDKSVSGGLLEVLKNCSSSRGGESFPLVAVQALASRQSENRQPVRCSFNSVAEGRYYDSGLLDERNDWCVPPRGVMQGAVGSALCLVRGVGAVNFDGSPDISVTSVASSVGDKVPSMIRGEQRRASTNSALPDVVPKVADPPLEAPVSLIEGEKVSVAWESQFGGSADPKERFLDLSTTPQHENPSRFLSRMGSLCRWGLGSQKAKCEDSAETLKRWAQDSTKYLIGVQEPDTVAEELPSLSDARGMPPMVKASSSSDKNFSQLGPFDTSNGDHKGEELTTLRRWSKSNQGKSIAGSGTEEPRSIATRNSDPNLPLLRIRKSASGSPLLPLATGDKGLAKWEDDGVTSLPPIISQSANTPLGCDAASKRRVGDSYVWDIRDVSMSSASPNTSYLDIEAEGEAFDIFKRLLHDIDVASRAISKPVQALRELRDGRKYENSS
Protein: Fe2OG dioxygenase domain-containing protein (Q57WP7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Multifunctional methyltransferase subunit TRM112
Sequence:
METHNTEPLGDFAKIRSRCHRYLLAVATHLSPIEKYVVAPGSYKNLGLIAINCGVQTGSGPFYLRQQLIAHTALSDASIELFYSSKFPFTLICGDTSFGDGLKPLKTRLIEVATTNGGPTAYVYAIPVPHEMLWKGGLLPSSGMSLLYLLCCKGDAVLHTLRRVFQPPTIGVGRVCDDPLQPSITGLLSMEEVGSGTSFTSDTAHTSYFYKGAKVRCVECVAVSEIPGLYIVSDFITHSEHNAIWNELNGDAASHFEVEHLARRDVAHFNRRFYYGINRVGAEGVQVNSRPAFYDWMAQRLCNTDSEVKIHNYPMKQHPEYFDQLTVNYYNYDDPKSKLVPGIARHVDSHDAFGDYIAIVSLGSHTVIEFSRYNRPPDVFAPLGVLVKPCSLLLLTGEARYCWTHCIVEKREDVLNDQLPPLQRGNRLSLTWRCGRDTPHARESCLCPSLCDGT
Protein: Amino acid transporter, putative (Q57V81)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MHSNNYVPSRHLTIRLVPRKSTRCQQKRLSQNTRKQQCWYAIFPLTLLLSPYLIFSISIKCVTTKTLNHQKKMTSINAQPPNSATYSQDDHGSAEVVNLNAEVERPQPEERKDGGGCFARVSLFMATIIPPGGIAASAFNIASSTIGAGIVGLPSAANSSGLVMAMIYLIIITAMSVFTMHNLAVVADKSSARTFEEITGKLLGRGASYCLAGVRAFHGFSGCVAYVISVGDILSATLKGTNAPDFLKQKSGNHLLTSLMWLCFMLPLVIPRHIDSLRHVSTIAVSFIIYLVIVIVVHSCMNGLPENIKNVSVGKDDNAEIILFNSGNRAIEGLGVFMFAYVCQVVAVEIYMDMTDRSPRRFVLASAIALGICFALYVMTAFFGYMDFGRAVTGSVLLMYDPVNEPAIMVGFVGVLVKLCASYALLGMACRNGLYSIVGWDADKVAFWKHCIAVVTLSVVMLLCGLFIPNINTVLGFAGSISGGSLGFLFPALLVMYSGGFTWQKVGPFYYLTTYAVLLTGVIAIVFGTGATIWGTATG
Protein: Electrogenic aspartate/glutamate antiporter Aralar, mitochondrial (Mitochondrial aspartate/glutamate carrier protein Aralar) (Q9VA73)
Organism: Drosophila melanogaster (Fruit fly)
Function: Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (By similarity). Necessary for gamma-aminobutyric acid (GABA) uptake in brain mitochondria in response to increased mitochondrial membrane polarization.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:O75746}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O75746}.
Interaction partners:
Sequence:
MPMHIPFPFNWIPTLPVARCQESPSLLKRAGTEKLREVFLKYASIQKNGEHYMTSEDFVRKFLGLFSESAFNDESVRLLANIADTSKDGLISFSEFQAFEGLLCTPDALYRTAFQLFDRKGNGTVSYADFADVVQKTELHSKIPFSLDGPFIKRYFGDKKQRLINYAEFTQLLHDFHEEHAMEAFRSKDPAGTGFISPLDFQDIIVNVKRHLLTPGVRDNLVSVTEGHKVSFPYFIAFTSLLNNMELIKQVYLHATEGSRTDMITKDQILLAAQTMSQITPLEIDILFHLAGAVHQAGRIDYSDLSNIAPEHYTKHMTHRLAEIKAVESPADRSAFIQVLESSYRFTLGSFAGAVGATVVYPIDLVKTRMQNQRAGSYIGEVAYRNSWDCFKKVVRHEGFMGLYRGLLPQLMGVAPEKAIKLTVNDLVRDKLTDKKGNIPTWAEVLAGGCAGASQVVFTNPLEIVKIRLQVAGEIASGSKIRAWSVVRELGLFGLYKGARACLLRDVPFSAIYFPTYAHTKAMMADKDGYNHPLTLLAAGAIAGVPAASLVTPADVIKTRLQVVARSGQTTYTGVWDATKKIMAEEGPRAFWKGTAARVFRSSPQFGVTLVTYELLQRLFYVDFGGTQPKGSEAHKITTPLEQAAASVTTENVDHIGGYRAAVPLLAGVESKFGLYLPRFGRGVTAASPSTATGS
Protein: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) (A9JSZ0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU361219}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU361219}. Peroxisome membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004585}.
Interaction partners:
- Hydroxymethylglutaryl-CoA synthase
- Mevalonate kinase
- Lanosterol 14-alpha demethylase
- UbiA prenyltransferase domain-containing protein 1
- Squalene synthase
- Squalene epoxidase a.
- 3-hydroxy-3-methylglutaryl coenzyme A reductase.
- Sterol regulatory element-binding protein 2
- Insulin-induced gene 1 protein
- Farnesyl pyrophosphate synthase
Sequence:
MLTRLFRIHGLFVASHPWEVIVATVTLTICMMSMNMFTGNNQICGWNFDCPKLDEQILSSDIIILTITRCIAIVYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSKACALAKFALSSNSQDEVRENIAKGMAVLGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEEDNKPNPVTQRVKMIMSLGLVMVHAHSRWIADPASSDGTLDLPEVGMSLNENLPKRIEPDMPLWHFYLSRMISMDIEQVITLGLALFLAVKYIFFEQVEMESTLSLKVPTPSSMLTQKWSPDQCCRKEIPYSTKLDKPPTPPPVVTKEERDLVIRPLPAPKEPEQKSTFVLGEDETQENTHVPEPVMSLPAEPRPVEDCLSILKNPDMGARYLSDEEVIVLVNSKHIPAYKLEAMMETPERGVMIRRKMLSPKFPEPSTLSCLPYKDYDYSKVMGTCCENVIGYMPVPVGVAGPLLLDGKQFQVPMATTEGCLVASTNRGCRAIALAGGASSRVLADGMTRGPVVRFPSACQAAEVKAWLESPEGFKTIKEAFDQTSRFARLEKLLIGLASRNLYIRFQSRTGDAMGMNMISKGTEQALARLKEEFPELQVLAVSGNYCTDKKPAAINWIEGRGKSVVCETTIPAKVVKEILKTSTEALVDVNISKNLVGSAMAGSIGGYNAHAANIVAAIYIACGQDPAQTVGSSNCITLMEASGATGEDLYISCTMPSIELGTVGGGTNLPPQQACLKMLGVLGASQECPGENARQLAKVVCATVLAGELSLMSALAAGHLVKSHMTHNRSKVNLQEAPGTCTKQAS
Protein: RAB5B, member RAS oncogene family (A0A8I5ZN01)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEQRSCQRVNPRIQGVQQAEVGAWIFMSRPSRTRASVVATEGGVASSKYVWN