wanglab/gogpt-training-data huggingface dataset:
Protein: ANK_REP_REGION domain-containing protein (Q9BI64)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MDFTRKIRKNRMMKPCCSTVCEMSHFEMSKNLQVLPKEQNKRNQSENAKLRKKQADKDSRERREIESLRERERHVEMCGSSGPEKYIVPISHFDLSRPTDRPMETVIEESVLSRRRAEEARNEQKHNEPLIDSNRKPIKLNIQAFKHGLHKSARQSNADEKLLLDNEHWMNLDNINSDDHKCPDGYFEPDTGQVLTMNVYRCPFVQAVIYSNSDRFFDLVIKNMNTIGRFCNQSCFCKQGRKNNLPHDKSNLLHFAAAYSTREFLERVTLEKFYRREIERRLRKQPKVDQTTVNFWISHYRDTIDQYQKDPHGNERLIPSEVAAEEGRLDIVEVFLETSLSKSLANLKASATSKYCSFLQYRHWCYGSLLSRLVENGILHELSEKHLLRVFAYITTDNFLHAADTALAKGYGEALDILERLGVGFKSVYASKQYTQYSDPNTRNNDIPGIISSDGNELFKRCDSSQPAHILAQYGHFKLFDKLTVEEKNDTDFHRVSALIELLEFSDDEVRSQLRFFRNIRRDNIFLFISQVIIRNRIGLLEDALQLAFTNSNNFTPINTRKLIYKDYGTPEHIALPMETALQRTGNMDTVEQIAKYYTKTDRHARKMIEEDALRCIRSIQNRARVCTEHLRLSIIFMMIKFVDPFSPKFRNILRMYLDQAMNDNVSQYVLKSFSMIRSKRFLSKQSFVTWSTAVNEAFQIVSQWNGSLEEADFVPKFLSETKKCGAQMFFPKQEFRSLLLTEEKRTEKKKYQAERRPRTEDDVMSKLAKAIEDFENLNL
Protein: Phosphopantothenoylcysteine decarboxylase (PPCDC) (EC 4.1.1.36) (AtCoaC1) (Halotolerance protein Hal3a) (AtHal3a) (Q9SWE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in plant growth, and salt and osmotic tolerance. Catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis. The enzyme is also able to decarboxylate pantothenoylcysteine to pantothenoylcysteamine.
Interaction partners:
- Pantothenate kinase 2
- Pantothenate kinase 1
- Phosphopantothenate--cysteine ligase 1
- Phosphopantetheine adenylyltransferase
- Dephospho-CoA kinase
- Probable myosin-binding protein 5
- Probable phosphopantothenoylcysteine decarboxylase
- Alkaline-phosphatase-like family protein
- FAD/NAD
- At3g20340
Sequence:
MENGKRDRQDMEVNTTPRKPRVLLAASGSVAAIKFGNLCHCFTEWAEVRAVVTKSSLHFLDKLSLPQEVTLYTDEDEWSSWNKIGDPVLHIELRRWADVLVIAPLSANTLGKIAGGLCDNLLTCIIRAWDYTKPLFVAPAMNTLMWNNPFTERHLLSLDELGITLIPPIKKRLACGDYGNGAMAEPSLIYSTVRLFWESQAHQQTGGTS
Protein: Mediator of RNA polymerase II transcription subunit 7 (CeMED7) (MED-7) (Lethal protein 49) (Mediator complex subunit 7) (Q95Q17)
Organism: Caenorhabditis elegans
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for germ cell development and gonadal growth.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Mediator of RNA polymerase II transcription subunit 6
- Mediator of RNA polymerase II transcription subunit 10
- Cyclin-dependent kinase 8
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 21
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 22
- Mediator of RNA polymerase II transcription subunit 8
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 18
Sequence:
MLPGFGAQTVSPFPNPPEYASAYTSDRINNGSAPPPPHPLTEFKVYGEEYRLEDDVIAPLKNAGVAELYKNKNNWKTEMKKLNRSAIVAFFDLVEILIRAPDHPMREEKMVDLHTIFINMHHLINEFRPVQARDSVRILQERQIEELSDICKDFKKYLRDGREVVDDQFQMIRGKLPAPPQPSELTRVKLQDGVLHMLQETEASDDVEMKEEEGSEYSKKKARLELLSREDGPPSVVHLLARQFHDISLKK
Protein: SET domain-containing protein (Q385Q6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MQLAEELKQKGNACFASGDVDGAVAAYQHAINCLTNDAIPDDRSGEQLDTTSEVGRMLAVLYSNLSNAYLSQHDYTGSWETAEEATRYDPIFVKAWVRYIHARRLDGYPFEAFVALLRHLRPLLRREAATSGGKTSEDVEASLSLPLYEVLGLSGVLPHIELHDFENGIGIVALQPIKPNEVILVEKRFETSFAEVQLNFRKNLTTTRIVSSFAQKVFAHQQRCSEEWKRFKKEFKGCWPRSPEDVPDDVRREISGTLRPELPPMEDRDFEELFLASTMCRYNCFHTGFFRACALANHSCMANAAMKLNSRGDSVTLIAVRPIAAGEFINVKYLSDAQFLMGVGKRREYLRSWLFWCDCSRCLSDRNGSSVSEHVQCGHCYRYTCVPLRGDGAESKEVDPLLSQVVPCSHCGLDCSWSPESCDGVERIIDSLKEATSCPSYYELQKWFLVNVRKVKELRVHPEHWLYRMLLYYFCFVVTPYIDDAFVGYQRVGWGAPNVGMLLLNFGFCSEYSLPSEGDCGTVRCNDPNTGNVTNNGSHDTDSIMDGKVLGDTLYILCLLWRLIEPFYPPYEGWAVHRAICYMVLFAHTHPKGEMVLPGSLTLQLLSKHGKYIGRNELSTWVAAYSRHKLPDSQKGILSVRQIKKAVEKV
Protein: WW domain-containing protein (Q581S3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- non-specific serine/threonine protein kinase
- Protein kinase, putative
Sequence:
MSRGERGVAPAKRLNRRKRGVRRRRNRAQTKASIPAVHASFACHICSKNHWTVSCPRLRLSPRDYPLMDREKGCWKCAQRGHSSAQCQVKKYRCSDCGGLHDTRDCEFDHKSEEWHEFFDSTTQHVFYCNSETGEVQWTPPTHKLDVVLWFCSNCSILLPTSVPECVKCRVPRPHSKVSDAASSSSSSVSESGSDDGSDDEGSESASDN
Protein: Myosin, light chain 13 (A0A060WZI6)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Interaction partners:
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Actin alpha 1, skeletal muscle
- Uncharacterized protein
- Uncharacterized protein
- ACTC protein
- Actin, alpha skeletal muscle
Sequence:
MAPKKKEEPKEAPKPKAPEPEPVKIPEFNPAEVVLEFTPEQIEDFKDAFQLFDRTPLNEMKITYGQCGDVIRALGQNPTNAEIMYVLGKPKPEEMATKMLDFDSFLPIHQHICKAKDRGTYEDFVEGLRVFDKLGDGTVMGAELRHVLASLGEKMKEDEVEQLMTNQEDANGCVNYEAFVKHVMAS
Protein: TOX high mobility group box family member 4 (Epidermal Langerhans cell protein LCP1) (O94842)
Organism: Homo sapiens (Human)
Function: Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation (By similarity).
Subcellular location: Nucleus {ECO:0000305|PubMed:20516061}. Note=Associated with chromatin.
Interaction partners:
- WD repeat-containing protein 82
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Serine/threonine-protein phosphatase 1 regulatory subunit 10
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Protein phosphatase 1 regulatory subunit 12A
Sequence:
MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHEDGVEDFRRQLPSQKTVVVEAGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVELDPAPPSQTPSPPPMATVDPASPAPASIEPPALSPSIVVNSTLSSYVANQASSGAGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQQAQIVTRSVLQAAAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKVRINLQQQPPPLQIKSVPLPTLKMQTTLVPPTVESSPERPMNNSPEAHTVEAPSPETICEMITDVVPEVESPSQMDVELVSGSPVALSPQPRCVRSGCENPPIVSKDWDNEYCSNECVVKHCRDVFLAWVASRNSNTVVFVK
Protein: Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (Ecdysteroid receptor) (HvEcR) (Nuclear receptor subfamily 1 group H member 1) (O18473)
Organism: Heliothis virescens (Tobacco budworm moth)
Function: Receptor for ecdysone. Binds to ecdysone response elements (ECRES) (By similarity).
Subcellular location: Nucleus.
Interaction partners:
Sequence:
MSLGARGYRRCDTLADMRRRWYNNGPFQTLRMLEESSSEVTSSSALGLPPAMVMSPESLASPEIGGLELWGYDDGITYSMAQSLGTCTMEQQQPQPQQQPQQTQPLPSMPLPMPPTTPKSENESMSSGREELSPASSVNGCSTDGEARRQKKGPAPRQQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYICKFGHACEMDIYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRKEKKAQREKDKLPVSTTTVDDHMPPIMQCDPPPPEAARILECVQHEVVPRFLNEKLMEQNRLKNVPPLTANQKSLIARLVWYQEGYEQPSEEDLKRVTQSDEDDEDSDMPFRQITEMTILTVQLIVEFAKGLPGFAKISQSDQITLLKACSSEVMMLRVARRYDAATDSVLFANNQAYTRDNYRKAGMAYVIEDLLHFCRCMYSMMMDNVHYALLTAIVIFSDRPGLEQPLLVEEIQRYYLNTLRVYILNQNSASPRGAVIFGEILGILTEIRTLGMQNSNMCISLKLKNRKLPPFLEEIWDVADVATTATPVAAEAPAPLAPAPPARPPATV
Protein: Nuclear factor of activated T-cells 1 (D3ZE20)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Protein phosphatase 3 catalytic subunit alpha
- Calcineurin subunit B type 1
- Calcineurin subunit B type 2
- Serine/threonine-protein phosphatase
- Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
- Mitogen-activated protein kinase 9
- Mitogen-activated protein kinase 8
- Nuclear factor of activated T-cells 2
- Mitogen-activated protein kinase 10
- Transcription factor GATA-4
Sequence:
MPSTSFPVPSKFPLGPPAAVCGSGETLRPAPLAGGTMKAAEEEHYSYASPSVTSTLPLPTAHSALPAACHDLQTSTPGISAVPSANHPSGYGGAVDSGPSGYFLSSGNTRPNGAPTLESPRIEITSYLGLHHGSNQFFHDVEVEDVLPSCKRSPSTATLHLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRSLGACHLLGSPRHSPSTSPRASVTEESWLGARGSRPTSPCNKRKYSLNGRQPSCSPHHSPTPSPHGSPRVSVTEDTWLGNTTQYTSSAIVAAINALTTDSTLDLGDGVPIKSRKTALEHVPSVALKVEPAGEDLGTTPPTSDFPPEEFAFQHLRKGAFCEQYLSVPQASYQWAKPKSLSPTSYMSPSLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPVVQLHGYLENEPLTLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVIGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVLEIPPFRNQRITSPVQVSFYVCNGKRKRSQYQHFTYLPANVPIIKTEPTDDFEPALTCGPMSQGLSPLPRPYYSQQLTAPPDPGSCLVAGFAPCSQRNTLMPTSPNASPKLHDLSSPAYAKGLANPGHSGHLGLQPPASEAPTMQELPRPMAVQPNSPEQPTSVRLQPQVSPHLNSSCPLGLQQVLYPNSPSSPLPPAAHEPTCLQPSALPPDVGHRQQQPQKVHRNESPSILPEVCEDSDHNLAPVPVVIKQEPEELDQLYLDDVNEIIRNDLSSTIPHS
Protein: CD1b molecule (H7C0I2)
Organism: Homo sapiens (Human)
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00046288}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00046288}.
Interaction partners:
Sequence:
XSSFTNSTWAQTQGSGWLDDLQIHGWDSDSGTAIFLKPWSKGNFSDKEVAELEEIFRVYIFGFAREVQDFAGDFQMKYPFEIQGIAGCELHSGGAIVSFLRGALGGLDFLSVKNASCVPSPEGGSRAQKFCALIIQYQGIMETVRILLYETCPRYLLGVLNAGKADLQRQVKPEAWLSSGPSPGPGRLQLVCHVSGFYPKPVWVMWMRGNPTSIGSIVLAIIVPSLLLLLCLALWYMRRRSYQNIP
Protein: RHOMBOID-like protein 1 (AtRBL1) (EC 3.4.21.105) (Q0WQX7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis. Unable to cleave the Drosophila protein Spitz.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:16223493}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Rhomboid-like protein 16, chloroplastic
- Rhomboid-like protein 14, mitochondrial
- Rhomboid-related intramembrane serine protease family protein
- Rhomboid-like protein 17, chloroplastic
- Rhomboid-like protein 11, chloroplastic
- Rhomboid-like protein 15
- RHOMBOID-like protein 13
- Probable zinc metalloprotease EGY2, chloroplastic
- AT2G34560 protein
- RHOMBOID-like protein 12, mitochondrial
Sequence:
MARDRREGLEIKVVNPPAAATNNVAVETSPATATRRRRQQQRASFAEFRPFKLWFPWLVPAIVVANIALFAISMFINNCPKNSAYCLARFLGRFAFQPMKENPLLGPSSLTLEKMGALDVSMVVHKHEVWRLFTCIWLHAGVFHVLANMLSLIFIGIRLEQEFGFVRIGLLYMISGFGGSLLSSLFNRAGISVGASGALFGLLGAMLSELLTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFLIRPQYGYFNQRNNPRGYAAPSAKSKHKPYQYVLWITSLVLLIAGYTAGLVVLLRGTDLNKHCSWCHYLSCIPTSLWSCKSQNVYCESSQIGQQMNLTCITNGKTEMYKLSNDIPSRIQQLCSQLCR
Protein: Thyroxine 5'-deiodinase (EC 1.21.99.4) (Iodothyronine deiodinase) (Q6U6H1)
Organism: Halocynthia roretzi (Sea squirt) (Cynthia roretzi)
Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Can also produce 3,3'-diiodothyronine from reverse T3 (rT3, 3,3',5'-triiodothyronine). Does not have significant inner-ring deiodination activity for T4, T3 or rT3.
Subcellular location: Membrane {ECO:0000269|PubMed:14657009}; Peripheral membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:14657009}.
Interaction partners:
Sequence:
MHNLLEIKIIRFLRNVFYFLHVLFNECLDTLKAYYKRWRGMKSEKPLDPSSRRARIIQATGVDLSRDPAMQSLRGVYHMAKSILYADVLRTAVRGGNAPNSSLVNYRTKEKCNILDFMKPGRPLVVNFGSCSUPPFMASFEIFSRIIDSYHERADFLTVYIEEAHSSDLWALKNNKYSIPSHITFEDRMEAAAIFKKSVSFECAFAVDTMKDETNLSYGALPERTAIILDGKVQYIGGIGPFNYDLVELEKELIAVLKK
Protein: D-mannonate dehydratase (ManD) (EC 4.2.1.8) (RspA homolog) (A4XF23)
Organism: Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199)
Function: Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro).
Interaction partners:
Sequence:
MKITAARVIITCPGRNFVTLKIETDQGVYGIGDATLNGRELSVVAYLQEHVAPCLIGMDPRRIEDIWQYVYRGAYWRRGPVTMRAIAAVDMALWDIKAKMAGMPLYQLLGGRSRDGIMVYGHANGSDIAETVEAVGHYIDMGYKAIRAQTGVPGIKDAYGVGRGKLYYEPADASLPSVTGWDTRKALNYVPKLFEELRKTYGFDHHLLHDGHHRYTPQEAANLGKMLEPYQLFWLEDCTPAENQEAFRLVRQHTVTPLAVGEIFNTIWDAKDLIQNQLIDYIRATVVGAGGLTHLRRIADLASLYQVRTGCHGATDLSPVTMGCALHFDTWVPNFGIQEYMRHTEETDAVFPHDYWFEKGELFVGETPGHGVDIDEELAAKYPYKPAYLPVARLEDGTMWNW
Protein: LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 1.1 (EC 2.7.11.1) (Probable receptor-like serine/threonine-protein kinase LRK10L-1.1) (Q9C6K9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane {ECO:0000269|PubMed:25510357}; Single-pass type I membrane protein {ECO:0000305}.
Interaction partners:
- CLAVATA3/ESR
- Splicing factor U2af small subunit A
Sequence:
METVSVLLFFFLFLLAAEARSTKRTGCKDFTCGEHDFKFPFFRTDMPSRCGLFKLNCSANIPEIQLEKDGKWYTVKSVSQANTITIIDPRLNQSLTTGGCSDLSSFSLPDSPWLKLNTLYKCNNSSRKNGFSYANCRGEGSSLYYNLGDDHDVSGCSPIKTPESWVTPKNGNLSDVNATFSLHIELPGNCFRCHNNGGECTKVKNNYRCVGANTEPNNYHAEMRLGLGIGGSVILIIILVALFAVIHRNYRRKDGSELSRDNSKSDVEFSQVFFKIPIFSYKELQAATDNFSKDRLLGDGGFGTVYYGKVRDGREVAVKRLYEHNYRRLEQFMNEIEILTRLHHKNLVSLYGCTSRRSRELLLVYEFIPNGTVADHLYGENTPHQGFLTWSMRLSIAIETASALAYLHASDIIHRDVKTTNILLDRNFGVKVADFGLSRLLPSDVTHVSTAPQGTPGYVDPEYHRCYHLTDKSDVYSFGVVLVELISSKPAVDISRCKSEINLSSLAINKIQNHATHELIDQNLGYATNEGVRKMTTMVAELAFQCLQQDNTMRPTMEQVVHELKGIQNEEQKCPTYDYREETIIPHPSPPDWGEAALLKNMKFPRSPVSVTDQWTSKSTTPNTSAYEF
Protein: Tlr protein (Q7JPR9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Interaction partners:
Sequence:
MPATSSIITIIAVAACLLLLVADAHAQQQCNWQYGLTTMDIRCSVRALESGTGTPLDLQVAEAAGRLDLQCSQELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTDHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAAQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKKFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLDVVLIIVFVFRESVRMWLFAHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRLLTCDRYFWEKLRYAIPIELSPRGNNYTLDHHERFKQPVSPGMIFRQAPPPPAYYCTEEMEANYSSATTATPSPRPTRPGGAARIVDSMPMPMRPPSEHIYHSIESEYSAYDQHEALSMIPTGLMHQHQQQQLRLHQQQQQQQQQRLLQPQFRAMPQQAIPAPSAPVHLRSGSGLSQASTSTQSTAQASTSAAAAQQQQQQQQQQAAGSEAANKNGQAFLV
Protein: Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) (P16612)
Organism: Rattus norvegicus (Rat)
Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
Subcellular location: Secreted {ECO:0000250}. Note=VEGF-A120 is acidic and freely secreted. VEGF-A164 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF-A188 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin (By similarity). {ECO:0000250}.
Interaction partners:
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 1
- Matrix metalloproteinase-9
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L1
- 72 kDa type IV collagenase
- Vascular endothelial growth factor receptor 3
- Receptor protein-tyrosine kinase
- Platelet-derived growth factor receptor beta
Sequence:
MNFLLSWVHWTLALLLYLHHAKWSQAAPTTEGEQKAHEVVKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNVTMQIMRIKPHQSQHIGEMSFLQHSRCECRPKKDRTKPEKKSVRGKGKGQKRKRKKSRFKSWSVHCEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Protein: Olfactory receptor (Q8VFA2)
Organism: Mus musculus (Mouse)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
Interaction partners:
Sequence:
MMQWNNWTRNSDFILLGFFDHSPLHTFFFSLILAIFFMALIGNSVMVILIYLDAQLHTPMYILLSQLSLMDLMLISTTVPQTAFNFLSGNKSISMAGCGVQIFFYVSLLGAECFLLAAMAYDRYVAICYPLRYPILMSHKICSLMAAFSWILGSLDGIIDVAAVLSFSYCGTREIPHFFCDIPALLTISCSDTLIFEKIIFFCCVIMLIFPVVIVIASYICVILAVIKMASAESRHKAFATCSSHVMVVVIYYGAAMFIYMQPSSSRSPNQDKLVSAFYTILTPLLNPLIYSLRNKEVARAFMKVLRMDKAAG
Protein: Caseinolytic mitochondrial matrix peptidase chaperone subunit X (H0YK07)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MSVLGRLGTFETQILQRAPLRSFTETPAYFASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQK
Protein: Sulfur carrier protein FdhD (Sulfurtransferase FdhD) (P32177)
Organism: Escherichia coli (strain K12)
Function: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Specifically interacts with IscS and stimulates its cysteine desulfurase activity. Also binds the molybdenum cofactor. Required for activity of formate dehydrogenase N (FDH-N), formate dehydrogenase O (FDH-O) and formate dehydrogenase H (FDH-H).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187, ECO:0000269|PubMed:2170340}.
Interaction partners:
- Formate dehydrogenase H
- Protein FdhE
- Protein YdeP
- Formate dehydrogenase-O major subunit
- Formate dehydrogenase, cytochrome b556
- Formate dehydrogenase-O iron-sulfur subunit
- Formate dehydrogenase, nitrate-inducible, major subunit
- GTP 3',8-cyclase
- Molybdopterin molybdenumtransferase
- Molybdopterin synthase catalytic subunit
Sequence:
MKKTQRKEIENVTNITGVRQIELWRRDDLQHPRLDEVAEEVPVALVYNGISHVVMMASPKDLEYFALGFSLSEGIIESPRDIFGMDVVPSCNGLEVQIELSSRRFMGLKERRRALAGRTGCGVCGVEQLNDIGKPVQPLPFTQTFDLNKLDDALRHLNDFQPVGQLTGCTHAAAWMLPSGELVGGHEDVGRHVALDKLLGRRSQEGESWQQGAVLVSSRASYEMVQKSAMCGVEILFAVSAATTLAVEVAERCNLTLVGFCKPGRATVYTHPQRLSN
Protein: Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Fatty acid activator 3) (Long-chain acyl-CoA synthetase 3) (P39002)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Activates endogenous long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. Acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10.
Subcellular location: Cell membrane {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Fatty acid synthase subunit beta dehydratase; Enoyl-[acyl-carrier-protein] reductase; [Acyl-carrier-protein] acetyltransferase; [Acyl-carrier-protein] malonyltransferase; S-acyl fatty acid synthase thioesterase]
- Fatty acid synthase subunit alpha reductase
- Long-chain-fatty-acid--CoA ligase 2
- Monoglyceride lipase
- Very long-chain fatty acid transport protein
- Long-chain-fatty-acid--CoA ligase 4
- Long-chain-fatty-acid--CoA ligase 1
- Triacylglycerol lipase 2
- Triacylglycerol lipase 3
- Triacylglycerol lipase 4
Sequence:
MSEQHSVAVGKAANEHETAPRRNVRVKKRPLIRPLNSSASTLYEFALECFNKGGKRDGMAWRDVIEIHETKKTIVRKVDGKDKSIEKTWLYYEMSPYKMMTYQELIWVMHDMGRGLAKIGIKPNGEHKFHIFASTSHKWMKIFLGCISQGIPVVTAYDTLGESGLIHSMVETESAAIFTDNQLLAKMIVPLQSAKDIKFLIHNEPIDPNDRRQNGKLYKAAKDAINKIREVRPDIKIYSFEEVVKIGKKSKDEVKLHPPEPKDLACIMYTSGSISAPKGVVLTHYNIVSGIAGVGHNVFGWIGSTDRVLSFLPLAHIFELVFEFEAFYWNGILGYGSVKTLTNTSTRNCKGDLVEFKPTIMIGVAAVWETVRKAILEKISDLTPVLQKIFWSAYSMKEKSVPCTGFLSRMVFKKVRQATGGHLKYIMNGGSAISIDAQKFFSIVLCPMIIGYGLTETVANACVLEPDHFEYGIVGDLVGSVTAKLVDVKDLGYYAKNNQGELLLKGAPVCSEYYKNPIETAVSFTYDGWFRTGDIVEWTPKGQLKIIDRRKNLVKTLNGEYIALEKLESVYRSNSYVKNICVYADESRVKPVGIVVPNPGPLSKFAVKLRIMKKGEDIENYIHDKALRNAVFKEMIATAKSQGLVGIELLCGIVFFDEEWTPENGFVTSAQKLKRREILAAVKSEVERVYKENS
Protein: WUSCHEL-related homeobox 11 (OsWOX11) (Q0D3I7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor involved in crown root development. Promotes the development of crown roots (both initiation and elongation), main components of the fibrous root system. Regulates the expression of genes required for crown root development, and hormone-responsive genes involved in cytokinin signaling (e.g. RR1, RR2, RR3 and RR4), and auxin signaling (e.g. IAA5, IAA11, IAA23 and IAA31). Functions dowstream of the auxin biosynthetic genes YUCCA1 in the promotion of crown root development. Recruits the ADA2-GCN5 histone acetyltransferase (HAT) module to regulate crown root cell proliferation and stem cell maintenance of root meristem. Together with the ADA2-GCN5 HAT module targets and regulates a set of root-specific genes involved in carbon metabolism, cell wall biosynthesis, and auxin transport and response. Functions upstream of several genes controlling root development, cytokinin homeostasis/signaling, stress response, and redox metabolic processes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:19258439, ECO:0000269|PubMed:26307379}.
Interaction partners:
- Lysine-specific demethylase JMJ705
- Os07g0185800 protein
Sequence:
MDGGHSPDRHAAAAAGEPVRSRWTPKPEQILILESIFNSGMVNPPKDETVRIRKLLERFGAVGDANVFYWFQNRRSRSRRRQRQLQAQAQAAAAAASSGSPPTASSGGLAPGHAGSPASSLGMFAHGAAGYSSSSSSSWPSSPPSVGMMMGDVDYGGGGDDLFAISRQMGYMDGGGGSSSSAAAGQHQQQQLYYSCQPATMTVFINGVATEVPRGPIDLRSMFGQDVMLVHSTGALLPANEYGILLHSLQMGESYFLVTRSS
Protein: Evasin P942 (A0A0K8R5I2)
Organism: Ixodes ricinus (Common tick) (Acarus ricinus)
Function: Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL10, CXCL11 and CXCL13.
Subcellular location: Secreted {ECO:0000305}.
Interaction partners:
Sequence:
MEVKTFAFLQIAVLIALGLHLAPAGSNQLSGPQSSANSNEAVFCDTNCTQGTDEAWSGCRGDCFCVYVGNSTEGRCMMLSGDFDYSTPGAED
Protein: Preprofallaxidin-3 [Cleaved into: Fallaxidin-1.1; Fallaxidin-1.2; Fallaxidin-1.3; Fallaxidin-3.2] (B5LUQ7)
Organism: Litoria fallax (Eastern dwarf tree frog) (Hylomantis fallax)
Function: Fallaxidin-1.1 shows no antibacterial activity against Gram-positive or Gram-negative bacteria. Does not inhibit the formation of NO by neuronal nitric oxide synthase. Has no effect on splenocyte proliferation or smooth muscle contraction.
Subcellular location: Secreted {ECO:0000269|PubMed:18803332}.
Interaction partners:
Sequence:
MASLKKSLFLVLFLGLVSLSICEEKKRENEDDAEDENHEEESEEKRGLLDFAKHVIGIASKLGKRSEEKRYHPFGKRSEEKRYFPIPFGKRSEEKRYFPIPIGKRSEEKRYFPIPIGKKKKKK