wanglab/gogpt-training-data huggingface dataset:
Protein: Protein BNS1 (P50084)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase and is required for the efficient segregation of telomeric and nucleolar regions. Although BNS1 can partially compensate for a lack of SPO12 function when overexpressed, it does not appear to play any role in controlling meiotic nuclear division.
Interaction partners:
- Separin
- Kinetochore protein SLK19
- Cell cycle serine/threonine-protein kinase CDC5/MSD2
- Sporulation-specific protein 12
- Cell division control protein 15
Sequence:
MSYGGSASQDIVTKLIRKIQNTSVSCTRRDENLDSFNQHLKMSLKVAHNTKTFAKHCLHRQVFKNTYRKRKAVEDQRKNLNTQLRQKFASPSDNLLSPCSRKLNDHKSKLFSAKSQPKTLEFVRGKQNIPRKPNVDI
Protein: Sox100B protein (Q9VA16)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MSDSSSSNCTKDRAKPVEALVLANYALKAEQKEAQGQGGRKEDERITTAVMKVLEGYDWNLVQASAKAPSDRKKEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRKKARVLPSQHSGDGGSPGPEMTLSATMGSSGKPRSSNSNGQRRAGKGNAAADLGSCAATISHANVGSSSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLTPPATPYNVAPSNAKASAANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLENINGYGGYTGSRVSYPAYSYPANGGHFATEEQQQQQALQASEALNYKPAAADIDPKEIDQYFMDQMLPMTQHHHPHHTHPLHHPLHHSPPLNSSASLSSACSSASSQQPVAEYYEHLGYSPAASSASQNPNFGPQQPYANGAASMTPTLGDPAPQQELQSQQQEQQHQNPSQHHLWGTYTYVNP
Protein: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) (NPP-7) (EC 3.1.4.12) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase) (Q3TIW9)
Organism: Mus musculus (Mouse)
Function: Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract. Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity (By similarity). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q6UWV6}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q6UWV6}. Note=The catalytic domain is released into the extracellular medium when cells are treated with trypsin. Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. {ECO:0000250|UniProtKB:Q6UWV6}.
Interaction partners:
Sequence:
MGHSAVLLCVALAILPACVTGAPVQRQHKLLLVSFDGFRWNYDQDVDTPNLDSMAQEGVKAQYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTSTVRLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEGVLHNYKNETEWRGNVDTVMKWFLEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLSDSLNLIITSDHGMTTVNKKASDLVEFHKFSNFTFQDIQFELLDYGPIGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKNFHYANNPRITPLLMYSDLGYVIHGRVNVQFNNGEHGFNNQDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCQLLGIVPEPNDGNPGILRPMLRSGSASLLSSQHHLVALLVGILTCLAKVL
Protein: F-box only protein 50 (W5UTZ0)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Interaction partners:
Sequence:
MAVWKQKCDSEWQLAANGAPLPDDVDWKSVYEKKPLERNLLKNPSPHGLTHDTPPPEREVTGERPDPDLPPQFEPTGDFSGWSTSIEQLPLDSSGIPPGVVVCYLPTFSWFSLEQRVDLKAEGLWDKLLDKFQPDIAIEDWYEESQLHASIYELHVKLLAADGQTVIKEHTCSPTEDLENYSHNWKQVSHVFSGYGPGVRYVHFQHKVKTKFMVEFFGTMVTGSSVVVKATKSSP
Protein: Ligand of numb-protein X 2 (B6DRF5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MGSLGEGVDPGMVSEALLEALCSECGQLHRTWENHLYNYRLEVDDDLVCHICLQPLVQPLDTPCGHTFCARCLRSFLQERDFCPLDRAHLQLQVCRRSSILVHKLLDKLSVTCPLTPSCSLSMPRCDLEAHLKHRCPGTQSQRTKLERTQMEGSEDRVTATNPPKSPQTEIKEDTPSPPAGSNACNNVPTWTEEPGIDNPAFEESTEEDSVHGLECALPRVKRPLSNPCIHLLRTGSSASSGWDFVETLPLSAEEGCVKLPSLPEGEITTIEVHRTNPYSEMGISIVGGNETPLINVVIQEVYRDGVIARDGRLLAGDQILQVNNVDISNVPHNFARSTLARPCATLQLTVLRERRCSARPPAATASPKGSPASIRITLHKGESSEQLGIKLVRRTDEAGVFILDLLEGGLAAKDGRLCSNDRVLAVDEHDLRHGTPELAAQIIQASGERVNLLISRSSKQTMAVHTGSTLTRDIWSHDHIPPLPSTATPSPVPSLHLARSSTQRDLSQCVNCKEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVQPHGCLSRDGRIKRGDVLLSINGQDLTYLSHSEAVGTLKSSATSCSVQLKALEVTMVEEPGLDEELLPPHENDYDASWSPSWVLWLGLPSYLHSSHEIVLRRSHPGSWGFSIVGGYEENHSNQAFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTAGMSHSALVPMLKEQRSRVALTVVSWPGSLI
Protein: Contactin-5 (Neural recognition molecule NB-2) (hNB-2) (O94779)
Organism: Homo sapiens (Human)
Function: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Interaction partners:
- Contactin-associated protein-like 4
- Amyloid beta precursor like protein 1
- Neuronal cell adhesion molecule
- CD177 antigen
- Amyloid-beta precursor protein
Sequence:
MASSWKLMLFLSVTMCLSEYSKSLPGLSTSYAALLRIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALMIPSTSW
Protein: Protein SLG1 (Cell wall integrity and stress response component 1) (Synthetic lethal with GAP protein 1) (P54867)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role during G1 to regulate entering or exiting the cell cycle. Involved in stress responses. Has a role in cell wall integrity signaling. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1. Important regulator of the actin cytoskeleton rearrangements in conditions of cell wall expansion and membrane stretching. Specifically required for the actin reorganization induced by hypo-osmotic shock. Multicopy suppressor of 1,3-beta-glucan synthase (GS). Activates GS upstream of RHO1. Acts positively on the PKC1-MAPK pathway. Activates transiently SLT2 during alkaline stress, which leads to an increase in the expression of several specific genes.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10430578}; Single-pass type I membrane protein {ECO:0000269|PubMed:10430578}.
Interaction partners:
- RHO1 GDP-GTP exchange protein 2
- Cell wall integrity sensor MID2
- RHO1 GDP-GTP exchange protein 1
- Protein kinase C-like 1
- Cell wall integrity and stress response component 2
- GTP-binding protein RHO1
- Cell wall integrity and stress response component 3
- Serine/threonine-protein kinase BCK1/SLK1/SSP31
- Protein MTL1
- Mitogen-activated protein kinase SLT2/MPK1
Sequence:
MRPNKTSLLLALLSILSQANAYEYVNCFSSLPSDFSKADSYNWQSSSHCNSECSAKGASYFALYNHSECYCGDTNPSGSESTSSSCNTYCFGYSSEMCGGEDAYSVYQLDSDTNSNSISSSDSSTESTSASSSTTSSTTSSTTSTTSSTTSSTTSSMASSSTVQNSPESTQAAASISTSQSSSTVTSESSLTSDTLATSSTSSQSQDATSIIYSTTFHTEGGSTIFVTNTITASAQNSGSATGTAGSDSTSGSKTHKKKANVGAIVGGVVGGVVGAVAIALCILLIVRHINMKREQDRMEKEYQEAIKPVEYPDKLYASSFSSNHGPSSGSFEEEHTKGQTDINPFDDSRRISNGTFINGGPGGKNNVLTVVNPDEAD
Protein: Lysosomal-associated membrane protein 2 (Lysosome-associated membrane glycoprotein 2 isoform X1) (A0A2R8Q0I4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane {ECO:0000256|PROSITE-ProRule:PRU00740}; Single-pass type I membrane protein {ECO:0000256|PROSITE-ProRule:PRU00740}.
Interaction partners:
Sequence:
MAVRGFLPLLFILLSGIVHADDMMTSPLPSTAELKTANLPLVIQTTSSTTSTTTTSRPSSTSTHSTLTTEPAAKTTTARTTVTTSAPTSTQSTSSSSTSATVTTLAPTTTGHNTTNSTTEPPTTTGHNTTNSTTDAPTTTHTNATVAPTPPPTTPSVPKPTVGNYSVKTDNVSDCLLAKMGLQFSFKISGNASLQTVNLDPNVTKVNGTCGSGGSDSSLFLTSKDITVHFVFTNDSQKFRLHALTLTVDLGNGNIFNDSNTNLSLWEASVGSSYMCRKEQSYNISDKLTLNTFELQVQPFDVKKNSFSTAEDCEADEPDNFIVPIAVGVALAVLVVVVLLAYLIGRKRSQNSGYEQFN
Protein: RRM domain-containing protein (O61711)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
- Poly
- Defective in germ line development protein 3
- Poly
- Poly
- Poly
- Female germline-specific tumor suppressor gld-1
- CCCH-type zinc finger protein oma-2
- PIP-1
- Fem-3 mRNA-binding factor 2
- FOG-1 protein
Sequence:
MNGQADRCDRTAYVSGLQPTISDIELFEVFNRVAHVEKVIVRNGAARHALIVFKTVQGLYQVLVNFQGTTLHGRQLHIRPLRESSHANSEAISTMFEKVKHQGNSGNSSYRQEHSFPEYRNQNPQASSYLPPNPRGHRNSTGCFNGGGGGYGRRRSAGGYNQYNQNKYPNETYPGMTLFDNHPVQQYSGFNPIDFRFDDYVEGAKRFDNLANLIRSSTPTDPFANYQKPCESTSTSRSRTNSAKDQKHGPPTWKMELQIKKDDHHHAGGGAATTGQKLSPQQFLAQIAQRQQSEQNADEVAKKKRPNLSVINPSLFYEQYPRTSSPVVYASKSKPSGHYDDKIASPHDPAVLAYSRLRVPQSAFDSLSPIDTDNCSFITKHLGPTTGVKRDLTNDELSDMIVSTGNLRINPTNIDHHDEPAPWSPLKRLRAESGSLSTAQVASPEFSPIKPKTMEFHETEDDVFETGPPPTYLSEGNENAEKKCVEQPKINYDDINNSRLPSNSHSAAPNSEKKHFVFPEYPMCRHSSVPSIAHLVGDLSDFCPHATADEKMLLDEASSIIENTTPAVSTAPAAAPGATMLQI
Protein: Lymphocyte antigen 9 (Q5VYH9)
Organism: Homo sapiens (Human)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MVAPKSHTDDWAPGPFSSKPQRSQLQIFSSVLQTSLLFLLMGLRASGKDSAPTVVSGILGGSVTLPLNISVDTEIENVIWIGPKNALAFARPKENVTIMVKSYLGRLDITKWSYSLCISNLTLNDAGSYKAQINQRNFEVTTEEEFTLFVYEQLQEPQVTMKSVKVSENFSCNITLMCSVKGAEKSVLYSWTPREPHASESNGGSILTVSRTPCDPDLPYICTAQNPVSQRSSLPVHVGQFCTDPGASRGGTTGETVVGVLGEPVTLPLALPACRDTEKVVWLFNTSIISKEREEAATADPLIKSRDPYKNRVWVSSQDCSLKISQLKIEDAGPYHAYVCSEASSVTSMTHVTLLIYRPERNTKLWIGLFLMVCLLCVGIFSWCIWKRKGRCSVPAFCSSQAEAPADTPEPTAGHTLYSVLSQGYEKLDTPLRPARQQPTPTSDSSSDSNLTTEEDEDRPEVHKPISGRYEVFDQVTQEGAGHDPAPEGQADYDPVTPYVTEVESVVGENTMYAQVFNLQGKTPVSQKEESSATIYCSIRKPQVVPPPQQNDLEIPESPTYENFT
Protein: Nuclear receptor domain-containing protein (O62496)
Organism: Caenorhabditis elegans
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004334}.
Interaction partners:
Sequence:
MCKICGSSESEPHFGGTSCRACAAFFRRFYHSKKLGLKCTCKTRQSNAHPCRSCRIRKCYEAGMTPEKIQLTRDKHLNRTIKLEGPCSSLDTPITSRQTPNLYCVLSNWHELKMTREEMNSGSLNNCNIFELTSFVLRDLELTWRMVSKAFPTVEVLEDRDRQALLRNFVPKLWQIEPILEYRECAEKFDNLEEEDYENLLVGFYGGTFPEGKEMSKSEIVSNFRPYWDYYYTKMILPISSMGLEELEYMAIVWLAFFDNGYSNISDNCLEMCRDIQKVILKELRNYQIDRNFHENRFFVALEALQIIERGEKKFMEEMLVCEMNHIRIHDDFRKIIREPKL
Protein: Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) (P35590)
Organism: Homo sapiens (Human)
Function: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:20227369}; Single-pass type I membrane protein {ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:20227369}.
Interaction partners:
- Angiopoietin-1
- Angiopoietin-2
- Angiopoietin-4
- Nitric oxide synthase 3
- Angiopoietin-related protein 2
- Platelet endothelial cell adhesion molecule
- Angiopoietin-1 receptor
- Cadherin-5
- Angiopoietin-related protein 3
- Vascular endothelial growth factor C
Sequence:
MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
Protein: Leucine-rich repeat transmembrane neuronal protein 2 (Q8BGA3)
Organism: Mus musculus (Mouse)
Function: Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).
Subcellular location: Cell membrane; Single-pass type I membrane protein. Postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized to excitatory synapses. {ECO:0000250}.
Interaction partners:
- Neurexin-3
- Neurexin-1
- Neurexin-2
- Disks large homolog 4
- Neuroligin-1
- Glutamate receptor 2
- Neuroligin-3
- Cerebellin-1
- Adhesion G protein-coupled receptor L3
Sequence:
MGLHFKWPLGAPMLAAIYAMSVVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITALERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMDWTWSTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLKSLTTVGLSGNLWECSPRVCALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTAMATTYRDPTTEYTKISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMIQNHRQLRSQTRLHMSNMSDQGPYNEYEPTHEGPFIIINGYGQCKCQQLPYKECEV
Protein: Trihelix transcription factor ENAP1 (Trihelix DNA-binding protein ENAP1) (Agrobacterium tumefaciens VirF-interacting protein 3) (EIN2 nuclear associated protein 1) (Q8VZI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription regulator. Associates with chromatin regions that are associated with ethylene-responses in absence and in presence of ethylene. In the presence of ethylene, promotes histone acetylation in an EIN2- and EIN3-dependent manner, mainly on H3K14 and H3K23, thus regulating positively ethylene-responsive genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00372, ECO:0000269|PubMed:26571494, ECO:0000269|PubMed:27694846}. Nucleus, nucleoplasm {ECO:0000269|PubMed:30338215}. Note=Observed in nucleoplasmic bodies. {ECO:0000269|PubMed:30338215}.
Interaction partners:
- Nucleolar complex-associated protein 3
- ELM2 domain-containing protein
- Nucleolar complex-associated protein 2
- Protein SLOW WALKER 2
- Tubby-like F-box protein 2
- Protein OBERON 1
- Protein REBELOTE
Sequence:
METTPETQSKTHRLPAGREDWWSEDATATLIEAWGDRYVNLNRGNLRQNDWKEVADAVNSSHGNGRPKTDVQCKNRIDTLKKKYKTEKAKPLSNWCFFDRLDFLIGPVMKKSSGAVVKSALMNPNLNPTGSKSTGSSLDDDDDDDDDDEEDDDDAGDWGFVVRKHRKVEDVDSSEGSAFRELARSILKLGEAFERIEGKKQQMMIELEKQRMEVAKELELQRMNMLMEMQLELEKSKLGKRRAASGKKL
Protein: Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.4.19.12) (Deubiquitinating enzyme 51) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51) (Q70EK9)
Organism: Homo sapiens (Human)
Function: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin.
Subcellular location: Chromosome {ECO:0000305|PubMed:27083998, ECO:0000305|PubMed:33022275}. Note=Upon DNA damage, chromatin-bound USP51 disassociates from chromatin immediately following DNA damage and reassociates with chromatin following DNA repair. {ECO:0000269|PubMed:27083998}.
Interaction partners:
- Transcription and mRNA export factor ENY2
- Ataxin-7-like protein 3
- SAGA-associated factor 29
- Transcriptional adapter 3
- Transformation/transcription domain-associated protein
- Ubiquitin carboxyl-terminal hydrolase 27
- Transcription initiation factor TFIID subunit 12
- Transcription initiation protein SPT3 homolog
- Transcriptional adapter 2-alpha
- Zinc finger E-box-binding homeobox 1
Sequence:
MAQVRETSLPSGSGVRWISGGGGGASPEEAVEKAGKMEEAAAGATKASSRREAEEMKLEPLQEREPAPEENLTWSSSGGDEKVLPSIPLRCHSSSSPVCPRRKPRPRPQPRARSRSQPGLSAPPPPPARPPPPPPPPPPPAPRPRAWRGSRRRSRPGSRPQTRRSCSGDLDGSGDPGGLGDWLLEVEFGQGPTGCSHVESFKVGKNWQKNLRLIYQRFVWSGTPETRKRKAKSCICHVCSTHMNRLHSCLSCVFFGCFTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYVYDKDIEQIAKETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCETKEQEPKLVKPKKKRRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRHSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLYSEGYLLFYHKQGLEKD
Protein: Mitochondrial fission factor (Q3ZCD8)
Organism: Bos taurus (Bovine)
Function: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q6PCP5}; Single-pass type IV membrane protein {ECO:0000255}. Peroxisome {ECO:0000250|UniProtKB:Q9GZY8}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q4KM98}.
Interaction partners:
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein mS29
- Large ribosomal subunit protein uL10m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein mL49
- Small ribosomal subunit protein uS5m
- Large ribosomal subunit protein mL43
- Large ribosomal subunit protein uL3m
Sequence:
MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQEGVSNASVIMQVPERIVVAGNNEDIPFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPAPTPQNEEIRAVGRLKRERSMSENAVRQNGQLVKTDSMYGISNIDAMIEGTSEDMTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR
Protein: Probable cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 9) (Q9TVL3)
Organism: Caenorhabditis elegans
Function: Essential member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and spt-5.
Subcellular location: Nucleus {ECO:0000269|PubMed:12183367}.
Interaction partners:
- Cyclin-T1.2
- Cyclin-T1.1
- Cyclin-like domain-containing protein
- Transcription elongation factor SPT5
- DNA-directed RNA polymerase II subunit RPB1
- Smad nuclear-interacting protein 1
- Mediator of RNA polymerase II transcription subunit 12
- Cyclin-H
- Transcription elongation factor SPT4
- Cyclin-C
Sequence:
MSAQNYHAGLHQSSTQRPPKRPNTEHAQEPPKRALIGGQTTPSSSGGGQTPNGTNYELEVKQQLSNYQKLFDQATYPFIRDVSTYEKLNKIGQGTFGEVFKARCKNTGRMVALKKILMENEKEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVMALCAHDLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLWSAMSSEPNSALPQGKYRILPNKMKNLMKFDAPDSKTDPFGKNVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDIWFFKDPVPMANVQDLMDTIPNSQFEYTVGKGAHANRGRHQNAQQRPNQQQARPSNAIPAGQYRDTIF
Protein: Choline transporter-like protein 2 (Solute carrier family 44 member 2) (Q8IWA5)
Organism: Homo sapiens (Human)
Function: Isoform 1, but not isoform 3, exhibits some choline transporter activity.
Subcellular location: Cell membrane {ECO:0000305|PubMed:33789160}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000305|PubMed:33789160}; Multi-pass membrane protein {ECO:0000255}. Note=Mainly expressed in mitochondria. {ECO:0000250|UniProtKB:B4F795}.
Interaction partners:
- Cochlin
- Kelch-like ECH-associated protein 1
Sequence:
MGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLSTSNEAVYKIFDDSPCPFTAKTCNPETFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNKTNKKAAES
Protein: fumarate hydratase (EC 4.2.1.2) (Q580J2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Malate dehydrogenase
- malate dehydrogenase
- Malic enzyme
- Malic enzyme
- Malate dehydrogenase
- Succinate dehydrogenase, putative
- malate dehydrogenase
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Citrate synthase
- fumarate hydratase
Sequence:
MSLCENCELGENCHGVDDIEETLPITTEFHYEPIFQPSDPHHDKTEYYNIPGDYVKEIEVMGRKVLSVDPTALTVLAQHAFTDVHHYFREDHLSGWRRVLDDPEATDNDRFVATTLLQNACVAAGRILPACQDTGTAIVLGKRGELCWTGGEDEKYLSHGIWKCYVSRNLRYSQTAALDMFKEANTGDNLPAQMDLMAVPGNEYHFLFVAKGGGSANKAFLYQQTKALLNPKSLRAFVEEKLKTLGTSACPPYHIALVIGGTSAEMTMKTVKLASCRYYDSLPTTGNKSGRAFRDIEWEEIILEMTRNLGIGAQFGGKYFAHQIRVIRLPRHGASCPVGLGVSCSADRQILGKITSEGVFLEKLVRDPAKYLPDVPLTSLGNGTVEVDLHQPMSKIRELLTQYPVTTRLSLTGPLIVARDIAHAKIMERLNADEPLPQYMKDHPIYYAGPAKTPKGMASGSFGPTTAGRMDSYVAPFMAAGGSFVTLAKGNRSKVVTDACKKYGGFYLGSIGGPAAILARDNIKKVEVVEYPELGMEAVWRIEVVNFPAFIIVDDKGNDFYAKLV