wanglab/gogpt-training-data huggingface dataset:
Protein: Divalent cation transporter (Q38F55)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MTVSEFGRSRVLYRRNGVSDVIEVGNTTELNDVIALLRSFSGVPKSYTTLVTPSLAELCEDAVGVERLWTSSAERTEPKDFAWLEVETESDEVMRQVLSAFPIHSKTSELVRSSENRVEVVEIFPSCGYVWVSIAAKGAASESSVPEDDEPVVVSLIAYEQFLITMHRKPLSGFEDMKAHMEMLVKSPASYGAPVPTAVCSLISGFVKEYQKELLSLLVDVDNVNELVLEIQPSECDQLDLLRRIDDLRHSLSRVQASYFAKERVLQRLLLPVVKRTFISSAVGVAARYQRMLSGLILSIERLRKGRDVLNMSSMGLVSGVSMRLLQRCYWMDYLNNVMTMMTLVSMPISIIPGLFTMNVRVPFEDSESFVPFYVIVAVTAGIFFLGMSYPVYLYLTFKSPGALVPTSH
Protein: Uncharacterized amino-acid permease P7G5.06 (Q9P768)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Cell tip. {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Sexual differentiation process protein isp7
Sequence:
MSSPDRSIDIDLEKYPSTATKSVYGQSKDDKNVFDIHPTESEVIPGEVEYADTPSHQNFLQKFFSDFKPVKADREDGVALKRHLKGRHMQMIAIGGAIGTGLFVGSGSSLADGGPASVIIDYTLIGIMMFFTVYALGELAVSYPVAGGFYNYAVRFIDPAWGFAVGWNYFMNYFVTFPLELTTCAITFRYWTDINSCAWITIFLVFVICINLFGVRGYGEVEFILSTLKVVATTGFIILAIIINCGGVPTDPRGYIGGKIIKNKPFRHSFKGFCSVFTTAGFSFSGTEVVGLAAAEAEDPQKSLPRATKQVFWRIAIFYVVSLILIGLLVSPDDPRLMGNSSDGSTSPFVLAIKEANIRGLPSVFNAVIIISTVSVANSCTFTASRTLHAMAAKGDAPRFFAYTDRLGRPLLAMAVCLLFGFFAYINAAGDVSDTVFDWLLAISGISNFFSWGSINLCHIVFRLAMKKQGRSLDQLGFVSPMGIWGSAIGLAFNILCLMAEFYVSLFPIGSKPNANDFFQGYLAAPIVIAFFIGYKIYDRSHIPSLSKLDLDTGLRTYPPKDKESEKIRDAKGFFKWIWQSLC
Protein: Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Serine-protein kinase PCK1) (EC 2.7.11.-) (A0A4X1UM84)
Organism: Sus scrofa (Pig)
Function: Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis. Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle (By similarity). At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity). At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (By similarity). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis (By similarity). The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (By similarity). In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor (By similarity). The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P35558}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P35558}. Note=Phosphorylation at Ser-90 promotes translocation to the endoplasmic reticulum. {ECO:0000250|UniProtKB:P35558}.
Interaction partners:
Sequence:
MPPQLSNGLNHSAKVVRGTLDSLPQAVRDFVESSAKLCQPDQIHICDGSEEENQQLLSHMEEEGVIKRLKKYDNCWLALTDPRDVARIESKTVIITQEQRDAVPIPRSGLSQLGRWMSPEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGSAVLDALGAGEFIKGLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLILGVTNPEGQKKYFAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDQQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQSNTIFTNVAETSDGGVYWEGIDQPLAPGIKLTSWKGTEWDPKDGEPCAHPNSRFCTPASQCPIIDPAWEAPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKDGRFLWPGFGENCRVLAWMFDRVQGKGGARLTPIGYVPEEAALDLRGLEAIRVSELFQVSKEFWEEEADEIHKYLEEQVNADLPYEIQSEVLALKQRISQM
Protein: Pleckstrin homology domain-containing protein (Q586T9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDAVHEAHLEKILERRRRRNAPNAAVTISCSPPAGAATDEQVQAIEGTETRRASSATSPKDLVSGNRPRAQEAVDAVPEVTRTCNSSAHSAEPTRGGAEDDRCVPCLVINVSTYPDSDSNRRRFTMLSTDTGYCSFPISPHGNPRGNGNCEGSRWEAACHRTNSLYSSVNGERGAINTVTALYDEFPIGRTVPQLSYSKPEACFNPSGENTNDLSMRRFGSPGRCVVRLVHRQPLEEACVQPLRYDSPNCTPVSRTGHADSLAVCPIFSLDTPRRGERVQHLQNTISRDTGKLEGDRLQSGELFLEAEEPKPLPAPLQVSPLPGAQGGVGTVSLRPNALTRLPVDELRLTTYAPVSLLCGGDWFYKWSSRAGTCSPRWVWVDIVNLFLLWAHWETFETTFARKIRLDHITRVCYKETCESEEVECRSPTRAPRTPHTLLVKTSRRLLRLSTESKSKADIWCKALANLLSHLTSPRSQATMSSDDPVAAITQLDDQSAHVV
Protein: MADS-box protein SOC1 (Agamous-like MADS-box protein AGL20) (Protein SUPPRESSOR OF CONSTANS OVEREXPRESSION 1) (O64645)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription activator active in flowering time control. May integrate signals from the photoperiod, vernalization and autonomous floral induction pathways. Can modulate class B and C homeotic genes expression. When associated with AGL24, mediates effect of gibberellins on flowering under short-day conditions, and regulates the expression of LEAFY (LFY), which links floral induction and floral development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:18466303, ECO:0000269|PubMed:31540691}. Cytoplasm {ECO:0000269|PubMed:18466303}. Note=Translocation from the cytoplasm to the nucleus in the presence of AGL24.
Interaction partners:
- Protein LEAFY
- B3 domain-containing transcription factor VRN1
- Protein TERMINAL FLOWER 1
- Protein TWIN SISTER of FT
- Inactive protein FRIGIDA
- Squamosa promoter-binding-like protein 3
- Protein GIGANTEA
- Polycomb group protein VERNALIZATION 2
- Protein VERNALIZATION INSENSITIVE 3
- Lysine-specific demethylase REF6
Sequence:
MVRGKTQMKRIENATSRQVTFSKRRNGLLKKAFELSVLCDAEVSLIIFSPKGKLYEFASSNMQDTIDRYLRHTKDRVSTKPVSEENMQHLKYEAANMMKKIEQLEASKRKLLGEGIGTCSIEELQQIEQQLEKSVKCIRARKTQVFKEQIEQLKQKEKALAAENEKLSEKWGSHESEVWSNKNQESTGRGDEESSPSSEVETQLFIGLPCSSRK
Protein: Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (PHS II) (Prostaglandin H2 synthase 2) (Prostaglandin-endoperoxide synthase 2) (F1MNI5)
Organism: Bos taurus (Bovine)
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Microsome membrane {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004174}. Nucleus inner membrane {ECO:0000256|ARBA:ARBA00004386}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004386}. Nucleus outer membrane {ECO:0000256|ARBA:ARBA00004509}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004509}.
Interaction partners:
Sequence:
MLARALLLCAAVALSGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHYSYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTDFERGPAFTKGKNHGVDLSHIYGESLERQHKLRLFKDGKMKYQMINGEMYPPTVKDTQVEMIYPPHVPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGLTQFVESFTRQRAGRVAGGRNLPVAVEKVSKASIDQSREMKYQSFNEYRKRFLLKPYESFEELTGEKEMAAELEALYGDIDAMEFYPALLVEKPRPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEVGFKIINTASIQSLICSNVKGCPFTSFSVQDTHLTKTVTINASSSHSGLDDINPTVLLKERSTEL
Protein: Histone H2B (U3KQK0)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000451}.
Interaction partners:
Sequence:
MPEPSKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSKKRKRRFTESIKKAHGFRKLKIWLKLRVSNQSPDDIYIARD
Protein: LysM domain receptor-like kinase 4 (LysM-containing receptor-like kinase 4) (EC 2.7.11.1) (O64825)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity. Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to the pathogenic fungus Alternaria brassicicola and to the bacterial pathogen the bacterial pathogen Pseudomonas syringae pv tomato DC3000, probably by sensing microbe-associated molecular pattern (MAMP) and pathogen-associated molecular patterns (PAMP). May play a role in detecting peptidoglycans (e.g. PGNs) during bacterial growth.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22744984}; Single-pass membrane protein {ECO:0000269|PubMed:22744984}.
Interaction partners:
- Protein LYK5
Sequence:
MISFSFHLLVFILLSLSSFATAQQPYVGISTTDCSVSDNTTSVFGYSCNGLNKTCQAYVIFRSTPSFSTVTSISSLFSVDPSLVSSLNDASPSTSFPSGQQVIIPLTCSCTGDDSQSNITYTIQPNDSYFAIANDTLQGLSTCQALAKQNNVSSQSLFPGMRIVVPIRCACPTAKQINEDGVKYLMSYTVVFEDTIAIISDRFGVETSKTLKANEMSFENSEVFPFTTILIPLVNPPANTNSLIPPPPPPPPQSVSPPPLSPDGRKSKKKTWVYALAGVLGGALVLSVIGAAIFCLSKKKTKTQTQEETGNLDSFMGKKPPMSDQEFDPLDGLSGMVVESLKVYKFHELQSATSDFTSSSSIGGSGYIGKINGDGAMIKKIEGNASEEVNLLSKLNHLNIIRLSGFCFHEGDWYLVYEHASNGSLSEWIHTTKSLLSLTQKLQIALDIATGLNYLHNFADPPYVHRDLNSNNVFLDLEFRAKIGSLGSARSTTEDFVLTKHVEGTRGYLAPEYLEHGLVSTKLDVYAFGVVLLEIVTGKEASELKKEIDEGKAIDEILIHGRLLPEGLTSFVERLVVDCLKKDHLNRPSMDENVMSLSKILAATQNWEESSY
Protein: Ras-related protein Rap-2c (EC 3.6.5.2) (Q9Y3L5)
Organism: Homo sapiens (Human)
Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17447155}. Recycling endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Interaction partners:
- Rap guanine nucleotide exchange factor 2
- Transforming protein RhoA
Sequence:
MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ
Protein: Jacalin-related lectin 32 (Myrosinase-binding protein-like At3g16440) (Myrosinase-binding protein-like protein-300B) (Protein MATERNAL EFFECT EMBRYO ARREST 36) (O04312)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in gametophytic development.
Interaction partners:
- Myrosinase 5
- At1g58270/F19C14_8
- Gibberellin-regulated protein 7
- TRAF-like family protein
- Protein RALF-like 34
- Receptor-like serine/threonine-protein kinase ALE2
- Germin-like protein subfamily T member 1
- Glucosidase 2 subunit beta
- Expressed protein
Sequence:
MAQKVEAQGGIGGDVWDDGAHDGVRKVHVGQGLDGVSFINVVYENGSQEVVGGEHGKKSLIGIETFEVDADDYIVAVQVTYDKIFGYDSDIITSITFSTFKGKTSPPYGLDTENKFVLKEKNGGKLVGFHGRAGEILYALGAYFTTTTTPLTPAKKLPAVGGDEGTAWDDGAFDGVKKVYIGQAQDGISAVKFVYDKGAEDIVGDEHGNDTLLGFEEFQLDYPSEYITAVEGTYDKIFGFETEVINMLRFKTNKKTSPPFGIEAGTAFELKEEGCKIVGFHGKVSAVLHQFGVHILPVTN
Protein: Mitochondrial nucleoid-associated protein 1 (Cell migration-inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC-8) (Protein C17orf80) (Q9BSJ5)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:37401363}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:37401363, ECO:0000269|PubMed:37676315}. Note=Retained in nucleoids under mtDNA replication stress caused by ddC and EtBr. {ECO:0000269|PubMed:37401363}.
Interaction partners:
- ATP synthase peripheral stalk subunit d, mitochondrial
- ATP synthase peripheral stalk subunit F6, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit b, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
Sequence:
MSDNPPRMEVCPYCKKPFKRLKSHLPYCKMIGPTIPTDQKVYQSKPATLPRAKKMKGPIKDLIKAKGKELETENEERNSKLVVDKPEQTVKTFPLPAVGLERAATTKADKDIKNPIQPSFKMLKNTKPMTTFQEETKAQFYASEKTSPKRELAKDLPKSGESRCNPSEAGASLLVGSIEPSLSNQDRKYSSTLPNDVQTTSGDLKLDKIDPQRQELLVKLLDVPTGDCHISPKNVSDGVKRVRTLLSNERDSKGRDHLSGVPTDVTVTETPEKNTESLILSLKMSSLGKIQVMEKQEKGLTLGVETCGSKGNAEKSMSATEKQERTVMSHGCENFNTRDSVTGKESQGERPHLSLFIPRETTYQFHSVSQSSSQSLASLATTFLQEKKAEAQNHHCVPDVKALMESPEGQLSLEPKSDSQFQASHTGCQSPLCSAQRHTPQSPFTNHAAAAGRKTLRSCMGLEWFPELYPGYLGLGVLPGKPQCWNAMTQKPQLISPQGERLSQVSLLERSSTHIRSLEPPAGLTTSNFSLMRLLGAVQKGWIRCNTTIRKSGFGGITMLFTGYFVLCCSWSFRRLKKLCRPLPWKSTVPPCIGVAKTTGDCRSKTCLD
Protein: exo-alpha-sialidase (EC 3.2.1.18) (G3XKV7)
Organism: Oryzias latipes (Japanese rice fish) (Japanese killifish)
Interaction partners:
- Arylsulfatase A
- Alpha-galactosidase
- Galactose-3-O-sulfotransferase 1a
- Galactose-3-O-sulfotransferase 1b
- Galactose-3-O-sulfotransferase 2
- UDP glycosyltransferase 8
- Galactocerebrosidase
Sequence:
MANAAHDKGRTTVFYSNKEQKEVYRIPSLLYDGDRGVLMVFAERRQTSNDASTEELVMKTGRLLQQEAPPLMSVEWSEAKTVVDKTRLGGYRPMNPCPVYERNSKTLFLVFISVEGTTTESWQRFWGINKARLCYVTTKDGGQTWSDVTNLTEKLPQIKKWATFAVGPGHGVQAESGRLIVPAYAYGSCCPSCFCIACFCAVPRALSLYSDDQGRTWQFGQPLETISIECEMAEVSDDGGNRYVYCNARTQGGFRVEALSDGGGDDFVTLPTADKLVETGGGCQGSVVSFPAQVDGGDPGQEPRWLLYSHPSSKDRRTDLGIYLNKSPKDPNSWSSPWIINQGPSGYSDLAYIDGGRFACLMERGTESVVEQIACGIFSYYQIKKGLEE
Protein: Neurofilament protein-like protein (F4J9K9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Protein CTR9 homolog
- Protein CDC73 homolog
- Protein PAF1 homolog
Sequence:
MASDSHTPTVTTPEKPLENKVSEEAKLMEKEIISSDSADVVNDKPASDSNPVVTKEEEIDQTPAGEPEKESPAVVEEVGAVVKAEESTETVKHENGEKGAEQVELKEPILVKETVAEVNVETVDTEKAEEKQTVENVLIEDHKDQEETKIVDVSESTDEAEVQQVEPVDVQPVKDAEKAEEKPTVESVVEEETKDREETKIVDVSESAGDKQVESVDVQSVRDVSAEIAEEKVKDVEALEVEPKPETSEKVETQLEKARELETEVEVVKAEETAEATEQAKVELEGKLEDVIVEEKDSEINSKDEKTSESGSALCSEEILSTIQESNTDPIKETEGDASYPIDVIEKAITEEKHVVDEPANEEKPSESSAALSPEKVVPINQDSDTKPKEETEGDAAAPADVIEKAITEEKYVVDEPSKDETTSESGSALCPEKAVPTNQDLDTEPKKETEEDVSSPADIIEKAITEEKHVVEEPSKDEKTSESGSALSPEKVVPTNQDSDTEPKKETEGDVPSPADVIEKAITDEKHVVEEPLKDEQENVSEAKDVVTKLAAEDENIKKDTDTPVAEGKSEETLKETDTESVEKEAAANKQEEPITEKVAEVVETAPVAKEIDEAKQQPEVTTKEAPAKQKHSNSIISKVKQSLVKAKKAIIGRSPSSKTITTEEPKEEIKV
Protein: Putative acetyltransferase YJL218W (EC 2.3.1.-) (P40892)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Interaction partners:
- Uncharacterized protein YDR132C
- Regulation of enolase protein 1
Sequence:
MGVLENIVPGELYDANYDPDLLKIRKETKIKLHEYNTLSPADENKKSQVIRELLGSCTDNFIIEPPFYCDYGSNIYIGDNFYANHNLVILDGAKVVIGDNVFIAPNVGIYTAGHPIDVERRLQGLEYAMPVTIGDNVWIGGGVSIIPGVNIGKNSVIAAGSVVIRDIPENVVAAGNPCKVIRKITEKDSTTTNYRK
Protein: Taste receptor type 2 member 20 (Taste receptor type 2 member 49) (T2R49) (Taste receptor type 2 member 56) (T2R56) (P59543)
Organism: Homo sapiens (Human)
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Subcellular location: Membrane; Multi-pass membrane protein.
Interaction partners:
- Taste receptor type 2 member 1
Sequence:
MMSFLHIVFSILVVVAFILGNFANGFIALINFIAWVKRQKISSADQIIAALAVSRVGLLWVILLHWYSTVLNPTSSNLKVIIFISNAWAVTNHFSIWLATSLSIFYLLKIVNFSRLIFHHLKRKAKSVVLVIVLGSLFFLVCHLVMKHTYINVWTEECEGNVTWKIKLRNAMHLSNLTVAMLANLIPFTLTLISFLLLIYSLCKHLKKMQLHGKGSQDPSTKIHIKALQTVTSFLILLAIYFLCLIISFWNFKMRPKEIVLMLCQAFGIIYPSFHSFILIWGNKTLKQTFLSVLWQVTCWAKGQNQSTP
Protein: Uncharacterized protein (Q389U7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSWMSALRSYIASPPHIKQRTGSDIFRQVARAHLLGPLGHTIHPCSVLVLRRLRWEIMRYGTSGQKAQALETILACYGDADRAHAHDAAGLEASQHMLTLEQLQCVVEAQVMGIPLRADHYRFLFQSSQLSQLGVEVPLLLLKEVQGVGVPLTDDALVDFSVGLTSSGHWREALQVLPRGHLLELVERVASVQRQGWRRSCSLVAHVKENNMVGYDEDTCNAVLSAHVLQWKAVRDPFNWEQVNQFVRVFSNTGRPWPRRALHYYLLHCPTEQWRQAVELVRGVIPMVENISCQALGRLMALLNEGCQWESSLFLYQRSSFSPPLSEQRCVPVQNQVLIALAKGGLWKEAVAMYTKMSARNNHTYTLWLNVVLLEGHVPFAATWRNCVEAYRHAPSCNDRFAVAMAYDLGKMGNWLMSLTVAQAAPKWTSQVLPIAIAAAVLSSGSWETVWQIASEFALSRHVSSVKQTCAVLAIIACCTRDPPSAVSGLIADALHSCVKSQRQFDESAHYMSKYMALLLHPPTLIGTKANLPPAISLLLATAGDFGNAKECWVFALSVMQSMSAKGWSLAAVAPVMLSSGFDASVAIHFLPA
Protein: ABC transporter G family member 7 (ABC transporter ABCG.7) (Q8T686)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
Sequence:
MEVISINNTNCNNINNNIDNTNIDTNSIHNKNNIDNNIDNNNIDNNSIGNNNNNIDNNNNNIANNNINNINNIDNNIDNNNNIDNNNNKNNSNNYNNIDNNNNNNNNNNNNNNNNNNIDNYNLVNNNNNNNNNSEISTPNFPYNNNNLTNLNSDNNIGVQVIFENISYKTENRNYKKQIKDEKKRKKKLEMERSNSSNSNSSYDVESSASGLQTPQQSRSSILPTNSLNISKIDQSMNPQQTRSTTNGKIEKEITILSNVSGIIEKSEMVGLFGPSGSGKSTLLDILANRKSTGTISGKILVNGKEIGDAYKKYCSYVTQDEILLQTSTVEETLKFHADLRLPGLSDQDKWKVVEQVIKDIGLTKKSKSKIGGILPGGMIVKGLSGGEKKRVSIGCALVTNPSLLFLDEPTSGLDSLNALKVMKVLMNLTVIKGVTVICSIHQPRPEIYHLFNKIMIMLKGRMIYCGNDVLNYLSSLPNQYQCPNYTNPADFILDTCHEISECDHYEEICESWETNWRDNMLAVSRIQPFNRSIEPNKSCSLLYQYKILLNRNFKDFFRNSTQYITRLSGGFMIGLLFSACFGTLSPSQEDVLKISGILFFLIAVLNLIPFTCITLFLSNREVFNSERASKIYHSLPFYLSTITTEAFIQFLVSLIVSLLVYTINHLRWNFSSFFITYFILYLINLLSDLYIIAISNITGKSDLTFIYGTTISITFLLFMGHLVPVKQLPKSFGWIHWLNPLYYGYATVMVAQFKDYPLECPNDFCQFPNGNDVLKFYNLEDWTLQKGIGIIILWICFFFVSGYWAISKLNKEKR
Protein: Scaffold attachment factor B, isoform E (Scaffold attachment factor B, isoform F) (A0A126GV03)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MPEAGKKIAELRVCDLKSELEKRELETVGPKAVLIERLEKSLRAEGLDPATHLIVPGAKAKKPFAMPMKDLQSEVVIKEEPIDANEEEVKVEQQDDYQNGNDYSHHADDDGHEIDQVGDVDDECVILDDDDEEDEDHVYDDEPQSGDGDAEGKAQDDGAENNGDDKAIIHGEEENTGDTGNMDNDESINLTIGEDEQKLLHDEASDDKSIKSVKPANKSEKSNSKDADKKNDDGARSKKRDEKSGDKKDSSEQKSSGKSSNQKDDKGKLS
Protein: Numb-like protein (Numb-related protein) (Numb-R) (Q9Y6R0)
Organism: Homo sapiens (Human)
Function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Subcellular location: Cytoplasm {ECO:0000250}. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. {ECO:0000250}.
Interaction partners:
- E3 ubiquitin-protein ligase LNX
- E3 ubiquitin-protein ligase Mdm2
- Neurogenic locus notch homolog protein 1
- Epidermal growth factor receptor substrate 15
- Neurogenic locus notch homolog protein 2
- Neurogenic locus notch homolog protein 3
- Protein numb homolog
- Neurogenic locus notch homolog protein 4
- Dihydropyrimidinase-related protein 2
- RNA-binding protein Musashi homolog 2
Sequence:
MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL
Protein: Dynamin-like protein (Q8IHR4)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- non-specific serine/threonine protein kinase
- Uncharacterized protein
- Mitochondrial fission 1 protein
Sequence:
METSMYNNLRKLINVIDELRDIGLQKYINLPRICVVGTQSSGKSSVLESIVGMDFLPRGEGIVTRRPIEFRLIHIKEDSEIKYWAVFENEKNKKYTDFNEVREQINRLTDEIAGKNKGIIDEPIVLNIYSIKCPDLSLIDLPGITRVPLKNSDQTDDIERLTRDMALRYVKDPRTIILAVLPANADMSTSDALQIARKVDPKGLRTIGVITKIDLMDKGADASKMLLNDEINLRLGYTGVVNRSTADIKKGKTISQALKDELEFFQKHPVYKKLPPALYGTNSLTDKLTKVLLRHIKNFLPDIKIEINDKIRYINDKLYELGTNVPLDATKKTQLLWSMITDYCEIFKNTLKGKYDKRVQVFIENNDILCGLKVRTIFNEFLDEYVGKNVTSELTDNDIDDAICLHEGDSLPGFPSPDTFEFLILPHLKKINAPVFNCLDRVSQTLEILSQKIANRVLNRFPKLSEQVLELSQTILIREKENTQIILENYIDAETNYLFTNDASYLIEHGSIINAADDEHNENHNNTTNINNNNNNNNSSSYDYGIQHRNQNKRQQSNISNSNQDTLLSTSSKYYSNMMSDQEYNITGKAAKFVTSAQKSVMNIWNTKEKKKTRYNAQFIQEIRRRLDCYFNIVLRNVRDSVPKMIGYFLIRKLQEKMQFELYSDLNSEQKLYDLLNEPPNVVKEREHLNNQLEILKKANQVLLKDPNITSINLDLFDANYEQDLMDYQKSLKNTNQFNQSSKHNPNMSQGSSANMSMYLNDGSSSMSKRNPMMHNRNMSPSSMNTNMMKQTNMLGQKMGNSPSSYMQQGHMNDSKGKHLFEKEPMKKKVNYNPLFD
Protein: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) (dPIMT) (Q27869)
Organism: Drosophila melanogaster (Fruit fly)
Function: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P22061}.
Interaction partners:
- Bifunctional glutamate/proline--tRNA ligase
Sequence:
MAWRSVGANNEDLIRQLKDHGVIASDAVAQAMKETDRKHYSPRNPYMDAPQPIGGGVTISAPHMHAFALEYLRDHLKPGARILDVGSGSGYLTACFYRYIKAKGVDADTRIVGIEHQAELVRRSKANLNTDDRSMLDSGQLLIVEGDGRKGYPPNAPYNAIHVGAAAPDTPTELINQLASGGRLIVPVGPDGGSQYMQQYDKDANGKVEMTRLMGVMYVPLTDLRS
Protein: Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)] (P34914)
Organism: Mus musculus (Mouse)
Function: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21217101, ECO:0000269|PubMed:7840649}. Peroxisome.
Interaction partners:
- Cytochrome P450 2C29
- Cytochrome P450 2J6
- Cytochrome P450 2C44
- unspecific monooxygenase
- Cytochrome P450 2J5
- Cytochrome P450 2C50
- Cytochrome P450 2C40
- Cytochrome P450 2C38
- Cytochrome P450 2C70
- Cytochrome P450 2C37
Sequence:
MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITFSQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTCIVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEVVFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYVTVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPFMPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHKATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLGRKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKWLQTEVQNPSVTSKI