wanglab/gogpt-training-data huggingface dataset:
Protein: DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) (Q3Y3Z1)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Heterochromatin protein 1
- SET-7
- YDG domain-containing protein
- DNA
- Histone H3
- Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5
- Adenosylhomocysteinase
- S-adenosylmethionine synthase
- adenosylmethionine decarboxylase
- ubiquitinyl hydrolase 1
Sequence:
MDSPDRSHGGMFIDVPAETMGFQEDYLDMFASVLSQGLAKEGDYAHHQPLPAGKEECLEPIAVATTITPSPDDPQLQLQLELEQQFQTESGLNGVDPAPAPESEDEADLPDGFSDESPDDDFVVQRSKHITVDLPVSTLINPRSTFQRIDENDNLVPPPQSTPERVAVEDLLKAAKAAGKNKEDYIEFELHDFNFYVNYAYHPQEMRPIQLVATKVLHDKYYFDGVLKYGNTKHYVTGMQVLELPVGNYGASLHSVKGQIWVRSKHNAKKEIYYLLKKPAFEYQRYYQPFLWIADLGKHVVDYCTRMVERKREVTLGCFKSDFIQWASKAHGKSKAFQNWRAQHPSDDFRTSVAANIGYIWKEINGVAGAKRAAGDQLFRELMIVKPGQYFRQEVPPGPVVTEGDRTVAATIVTPYIKECFGHMILGKVLRLAGEDAEKEKEVKLAKRLKIENKNATKADTKDDMKNDTATESLPTPLRSLPVQVLEATPIESDIVSIVSSDLPPSENNPPPLTNGSVKPKAKANPKPKPSTQPLHAAHVKYLSQELVNKIKVGDVISTPRDDSSNTDTKWKPTDTDDHRWFGLVQRVHTAKTKSSGRGLNSKSFDVIWFYRPEDTPCCAMKYKWRNELFLSNHCTCQEGHHARVKGNEVLAVHPVDWFGTPESNKGEFFVRQLYESEQRRWITLQKDHLTCYHNQPPKPPTAPYKPGDTVLATLSPSDKFSDPYEVVEYFTQGEKETAFVRLRKLLRRRKVDRQDAPANELVYTEDLVDVRAERIVGKCIMRCFRPDERVPSPYDRGGTGNMFFITHRQDHGRCVPLDTLPPTLRQGFNPLGNLGKPKLRGMDLYCGGGNFGRGLEEGGVVEMRWANDIWDKAIHTYMANTPDPNKTNPFLGSVDDLLRLALEGKFSDNVPRPGEVDFIAAGSPCPGFSLLTQDKKVLNQVKNQSLVASFASFVDFYRPKYGVLENVSGIVQTFVNRKQDVLSQLFCALVGMGYQAQLILGDAWAHGAPQSRERVFLYFAAPGLPLPDPPLPSHSHYRVKNRNIGFLCNGESYVQRSFIPTAFKFVSAGEGTADLPKIGDGKPDACVRFPDHRLASGITPYIRAQYACIPTHPYGMNFIKAWNNGNGVMSKSDRDLFPSEGKTRTSDASVGWKRLNPKTLFPTVTTTSNPSDARMGPGLHWDEDRPYTVQEMRRAQGYLDEEVLVGRTTDQWKLVGNSVSRHMALAIGLKFREAWLGTLYDESAVVATATATATTAAAVGVTVPVMEEPGIGTTESSRPSRSPVHTAVDLDDSKSERSRSTTPATVLSTSSAAGDGSANAAGLEDDDNDDMEMMEVTRKRSSPAVDEEGMRPSKVQKVEVTVASPASRRSSRQASRNPTASPSSKASKATTHEAPAPEELESDAESYSETYDKEGFDGDYHSGHEDQYSEEDEEEEYAEPETMTVNGMTIVKL
Protein: Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) (Q86W92)
Organism: Homo sapiens (Human)
Function: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:24120883}.
Interaction partners:
- Receptor-type tyrosine-protein phosphatase F
- Liprin-alpha-1
- Receptor-type tyrosine-protein phosphatase S
- Liprin-alpha-3
- Liprin-alpha-2
- Receptor-type tyrosine-protein phosphatase delta
- Liprin-alpha-4
- KN motif and ankyrin repeat domain-containing protein 2
- ELKS/Rab6-interacting/CAST family member 1
- Protein transport protein Sec31A
Sequence:
MMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTAETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEELLNSSSISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILGATVDTQLCDKLLTSSLQKSSSLGNLKKETSDGEKETIQKTSEDRAPAESRPFGTLPPRPPGQDTSMDDNPFGTRKVRSSFGRGFFKIKSNKRTASAPNLAETEKETAEHLDLAGASSRPKDSQRNSPFQIPPPSPDSKKKSRGIMKLFGKLRRSQSTTFNPDDMSEPEFKRGGTRATAGPRLGWSRDLGQSNSDLDMPFAKWTKEQVCNWLMEQGLGSYLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGSEEETNHGKLDFNWVTRWLDDIGLPQYKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENTIAPSEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKVKPKKLAFSNFGNLRKKKQEDGEEYVCPMELGQASGSASKKGFKPGLDMRLYEEDDLDRLEQMEDSEGTVRQIGAFSEGINNLTHMLKEDDMFKDFAARSPSASITDEDSNV
Protein: Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC 1.1.1.8) (A7LPE6)
Organism: Caenorhabditis elegans
Interaction partners:
Sequence:
MSPKKVTIIGSGNWGSAIARIVGSTTKSFPDEFDPTVRMWVFEEIVNGEKLSEVINNRHENIKYLPGKVLPNNVVAVTDLVESCEGSNVLVFVVPHQFVKGICEKLVGKIPADTQAISLIKGISFDKTNQGVSTEKRGGLKLISEEIKEILKIEVSVLMGANLAPEVANDNFCEATIGCKRKAEDGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVEHYYPGSNLQTFFESCGIADLITTCYGGRNRKVCEAFVKTGKSMAEVEKELLNGQSAQGPLTAEEVYLMMHKTGLDAKFPLFTAVHKICAGEMKPAELVDCLRNHPEHM
Protein: Y' element ATP-dependent helicase protein 1 copy 2 (EC 3.6.4.12) (P40105)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Interaction partners:
- UPF0479 membrane protein YEL077W-A
- Putative uncharacterized protein YER190C-A
- Uncharacterized protein YER189W
- UPF0320 protein YER188C-A
- Uncharacterized protein YEL075C
Sequence:
MVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEKASARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETALKDSYRITLVPSSDGVSVCGKLFNREYVRGFYFACKAQFDNLWEELNDCFYMPTVVDIASLILRNREVLFREPKRGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMIHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDILLCRDSSREVGE
Protein: Trans-splicing factor, putative (Q389Q8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- H/ACA ribonucleoprotein complex subunit 2
- Uncharacterized protein
- U5 small nuclear ribonucleoprotein component, putative
- U6 snRNA-associated Sm-like protein LSm8p
- Spliceosomal U5 snRNP-specific protein, putative
- U6 snRNA-associated Sm-like protein LSm4
- Small nuclear ribonucleoprotein E
- Sm protein G
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein SmD1
Sequence:
MSYIETGWDGFGERVDDLQSRRDEGLDIYLEETIGVGESIASDDDARRHNSVKEVTALLRSGHMSSMLQKLSDYSEQENVKNTITPDDPEYQFVIDSSNLVLRIEVEKSKAVVYARAHYSQRFPELAMFFTSGLLYARVVQLLQNNMDLSQVIDQLDELVPSQLTAVIIACASTTTGRELSPEELQRVLEACQEIETLEAAKQTFLEYIQRSMPLICPNLCAFLGTGITSQLFAIAGGVAPLAAMDPTELSRLGSTRANSSGIALKTTGFLSNSDFVVNHPPQLRPKALRLVSSTATVLARIDANRRAASHQEGVRQRELVRLKMLSWLDPPVLRGAGNNTYERRRRKRPRRNLR
Protein: Protein kinase, putative (Q586V3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSPSKGEHLKLSAGDLIDNRFEVLEEVGCGNFSKVYYCFGTPKAGGVRRQPVAVKVVKKEYKNDAYFEQEMLQILSQKKNGRASVCQMLEFFEWKGYPVFVMKIYGPSLRERRLGYANGVVTREKVVQVAHSLLETCRFIHIDCRMVHTDLKPENILLENITTSKSSIGDNWVVCDFGSSSLWRMDHLDSDLITTRPYRAPEVVLGNPWYHPADMWSVGCIIFELAIGRRLFDVRDDLTHLQLMERCLGPLPDLFRRRSKNSRSFFDQNGNFLRDCDDVILGRMRSRTLAELLPGDTELCDLIASMLVYDPESRATAEEALKHRIFKQPFILSNSTASNKRSNTPARGGNPIKKLATPRATSSIRVKAIVGSGNAKEAQNGQPAVRIPVCDKVTPTSSHNKSIDGDGATDTKWSRPIENVNRNFCEPAHAPGLPALEQPTSTRHPSLSTVCGKSVTDSKHISQQPMEVETAYDRKPFETSVAMLQSSKSNTSSVVISSVPSFTKEGERKKGRNGPVATLRSGTDCDQSSPQNTLVELLPTTPSAEAGSQPGMTSSPGRQADVSCGSNPSPVIAHPTKTIPTKEKECVRESHKELSISRDLECVPPSKRTTYGKETVGALHEYQLGTGAGTDVNAEASPTSTEGALTTFGKTPTDAAEAYERLASSTPSTMKGKESSKRKQREPVSMRSPSKPGHVSATVFDTGRMVTEAPFPPHCSTVVEPRGDSSTNKGVPAPFLLSGEAYFVAFPHVGGPVVHTSNETILPNIAKDQRHHLAPFTPRQQQQRRYEPKTLRSPPPASVGQPTLQRINTVYATTSGNKMFPNEMYGRGDAGRPSNRQSSTPTTTQGRSSTVSASEVGRNSRQNSTSLSESCKNLYQLSRLQAVPAFKAKDHPSPPQQVAYVTGKRRIVNSNSQVSVSVSAQGSTGSSAKAPRKSVGAKEMPGDTHGNRQSITGSRDVRRRVVSSYSTVNEGNIRRKGTSAQQDNMDERVNLITGNIADFIGISSARGKTKPSMEGGSNYHPAHIPYPPSSEAHGKRK
Protein: Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) (Q02293)
Organism: Rattus norvegicus (Rat)
Function: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
Interaction partners:
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- CAAX prenyl protease 2
- Geranylgeranyl pyrophosphate synthase
- CAAX prenyl protease
- All trans-polyprenyl-diphosphate synthase PDSS1
- Alkyl transferase
- Dehydrodolichyl diphosphate synthase complex subunit NUS1
- All trans-polyprenyl-diphosphate synthase PDSS2
- Squalene synthase
- Guanine nucleotide-binding protein subunit gamma
Sequence:
MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD
Protein: Acylcarnitine hydrolase (ACH M1) (EC 3.1.1.28) (Carboxylesterase 2) (CES 2) (Carboxylic ester hydrolase) (EC 3.1.1.-) (Peroxisome proliferator-inducible acylcarnitine hydrolase) (Q91WG0)
Organism: Mus musculus (Mouse)
Function: Hydrolase with high activity towards palmitoylcarnitine. Is also active with p-nitrophenylacetate and alpha-naphthylacetate. May also hydrolyze retinyl esters (By similarity).
Subcellular location: Microsome {ECO:0000269|PubMed:12859986}. Endoplasmic reticulum {ECO:0000305}.
Interaction partners:
- Beta-glucuronidase
- Cytidine deaminase
- UDP-glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase 2B17
- UDP-glucuronosyltransferase
- glucuronosyltransferase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase 2A3
Sequence:
MTRNQLHNWLNAGFFGLLLLLIHVQGQDSPEANPIRNTHTGQIQGSLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQNLDMLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIGMASMFDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDQHARGNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVALLPDLISETSEMVSTTVAKLSGCEAMDSQALVRCLRGKSEAEILAINKVFKMIPAVVDGEFFPRHPKELLASEDFHPVPSIIGVNNDEFGWSIPVVMGSAQMIKGITRENLQAVLKDTAVQMMLPPECSDLLMEEYMGDTEDAQTLQIQFTEMMGDFMFVIPALQVAHFQRSHAPVYFYEFQHPPSYFKDVRPPHVKADHADEIPFVFASFFWGMKLDFTEEEELLSRRMMKYWANFARHGNPNSEGLPYWPVMDHDEQYLQLDIQPAVGRALKAGRLQFWTKTLPQKIQELKASQDKHREL
Protein: Uncharacterized protein C30C2.07 (Q9P6K4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Folliculin-like protein bhd1
- V-type proton ATPase subunit C
- V-type proton ATPase subunit B
- Ypt/Rab-type GTPase ypt71
- V-type proton ATPase subunit D
- Phosphoribosylglycinamide formyltransferase
- V-type proton ATPase subunit E
- Protein byr4
- Serine/threonine-protein kinase crk1
- V-type proton ATPase subunit H
Sequence:
MLHFLFHSGSSSNRNSSPKESYELLHGLDKQYQSTKDVTFRLVLVQDIGDRKKTVLFDSNHVDGQKGDSVLRDSANAPLTDLMFGAIPISHKGTTTKLHILHPPNPATRSYMLTQLFQINTHGTVVNSSHETIASATSLFENSSSNFSEDPNKPNSSDAFESNKEDSPLLKSFNDSAIPENAANLSSSSKNMKDSTLSSQKARSNTSSSFLTPLHEQLESRCALHTAAKDPFRSKNSLRCNRGHSPLSSQQILPAISNNTSEKPDSNNCGFLLPSNSTSIKDLKNVKKGNRLNSPPFITIPQSIKNTNSNFLLSSPSLFSDTRTRPASYALALIITVPYEYDEIVHPVSTYYTMLSNFTLSLQKEIDERIRNLLFVSLSSGGDNKNDTGIPLIQSSSSKVGFGPYALSKDLITAKSFHKCILLLKTGFSAPLIKPSVFSGSKWVENMRLLTDLCKSPAQKCLFSNLLTATRKFCLERQKDDVTFKVLLQSSKAPIARRFLYLLAPLMRPSIAQCSDTLLNPIQLYPNSGILSSSSLSTSFGCPSVSGSLRVPSYDMKINDSCKAIDIHSEKPSFADSPRKTSLRNYLSSSWRLKFMRSSYQNNETDPLNPTSGSFLRQPMQYSSPSGVSESAASSFLDIENIDEYLESAENMKYLPRSTVGPGGMLHVDLLETNAKQESEATTSTVPPSPSQVGFLKALHPSFDLQAAPPNSYVSFSDDDFISATLLYMLEDVSRNKSQLLAEKKHLKSQLMVANLDTYSLDCYEIHEFPSEWENDYAPFLLKEHHKVIGETYVSSFDIQQGCFNVIKRRLSSYKWDKSDDSFVSEVLKGDLKEVLRVCSHC
Protein: Transcription factor SOX-3 (P53784)
Organism: Mus musculus (Mouse)
Function: Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
Subcellular location: Nucleus.
Interaction partners:
- POU domain, class 5, transcription factor 1
- Pituitary-specific positive transcription factor 1
- Homeobox protein OTX2
- Sulfhydryl oxidase 1
Sequence:
MYSLLETELKNPVGPPTPAAGTGVPAAPGAAGKSGANPAGGANAGNGGSGGANGGGGGGGGGGSDQDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSLPGGLLPPGAAAAAAAAAAAAAASSPVGVGQRLDTYTHVNGWANGAYSLVQEQLGYAQPPSMSSPPPPPALPQMHRYDMAGLQYSPMMPPGAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAIASHSQRACLGDLRDMISMYLPPGGDAADAASPLPGGRLHGVHQHYQGAGTAVNGTVPLTHI
Protein: AT3g19120/MVI11_3 (PIF / Ping-Pong family of plant transposase) (Q9LJL8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
- Fantom protein
- Increased DNA methylation 1
Sequence:
MEEAFMAMLSHLLHLQNSLDPTSTLFSSASTSSQSSTTPSSLLSTSSAAPLLFFTLASLLSFLAVNRSSTESSSSSESPSPSPPPPLADGDYSVAAFRALTTDHIWSLDAPLRDARWRSLYGLSYPVFITVVDKLKPFITASNLSLPADYAVAMVLSRLAHGCSAKTLASRYSLDPYLISKITNMVTRLLATKLYPEFIKIPVGKRRLIETTQGFEELTSLPNICGAIDSTPVKLRRRTKLNPRNIYGCKYGYDAVLLQVVADHKKIFWDVCVKAPGGEDDSSHFRDSLLYKRLTSGDIVWEKVINIRGHHVRPYIVGDWCYPLLSFLMTPFSPNGSGTPPENLFDGMLMKGRSVVVEAIGLLKARWKILQSLNVGVNHAPQTIVACCVLHNLCQIAREPEPEIWKDPDEAGTPARVLESERQFYYYGESLRQALAEDLHQRLSSR
Protein: Achaete-scute homolog 1 (ASH-1) (mASH-1) (mASH1) (Q02067)
Organism: Mus musculus (Mouse)
Function: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach.
Subcellular location: Nucleus {ECO:0000269|PubMed:1576967}.
Interaction partners:
- Neurogenic differentiation factor 1
- Myelin transcription factor 1-like protein
- DNA-binding protein inhibitor ID-4
- Transcription factor E2-alpha
- POU domain, class 3, transcription factor 2
- Homeobox protein DLX-2
- Neurogenin-2
- Transcription factor 12
- Homeobox protein Nkx-2.2
- Neurogenin-1
Sequence:
MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAQSAQQQQPQAPPQQAPQLSPVADSQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
Protein: Diphthine--ammonia ligase (EC 6.3.1.14) (Diphthamide synthase) (Diphthamide synthetase) (Q387L5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Elongation factor 2
- Elongation factor 2
- U5 small nuclear ribonucleoprotein component, putative
- Elongation factor G, mitochondrial
- NOT1
- Cell differentiation protein, putative
Sequence:
MKTIALISGGKDSILSIILSMRYGHYPVVVANIAPECDDGRETVHEVDSYSFQTVGHEVVEEIAACMQLPFRRGYIRADQAKVQDLHYTSKRDEGDEIEALYRLLRSVKEEFPEVEAVTSGAILSNYQRHRVEDVCSRLKLRSLAFLWQRPAEEILDIATILRVEAILVKTATVGLVPQKHLGTSLLAARPELESIQRLYGAHAAGEGGEFETIVLDCPLFREKRLEVVELRPVIVDNNDYSPSGHAVLKVAQRAKTDEEKVADKHILQQLSLFTFPSDRMKHLPSLDQLIFEDLQMNENKAAFQTRKSEGDVEYWACTCGVYDACITSDRGAQQRILEDVLRKAIEDASKITHEVFFVLVLSPNVDLFDCFCAAFSIAFPDVCPPGCSFAEMNSLSAFRLEVLTAPQCSIDRSTMVVRSTSCWGAPSLGPYSFSNMLRVANECRTIVSGCVGLVSTTHQLATVADMGDLNVTSISEVCHCIGIPDEGTVKEFIAQFAFMYANSVNGLTYFRIQPNEVTHVTFLLTDMRFAPLLGPLWRWCSAKHGGGRELIFYRVTNLSGVPGKYVVCRVLPVVRLLCGAAVEAIFERRITADEREGT
Protein: Inactive rhomboid protein 2 (iRhom2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 6) (Rhomboid-related protein) (Q80WQ6)
Organism: Mus musculus (Mouse)
Function: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21439629}; Multi-pass membrane protein {ECO:0000269|PubMed:21439629}.
Interaction partners:
- Eukaryotic translation initiation factor 3 subunit F
- Disintegrin and metalloproteinase domain-containing protein 17
- Translocon-associated protein subunit beta
- Bone morphogenetic protein 1
- Complement C1s-1 subcomponent
- Complement C1s-1 subcomponent
- Pro-epidermal growth factor
- FERM domain-containing protein 8
- A disintegrin and metalloproteinase with thrombospondin motifs 13
- Complement C1r-B subcomponent
Sequence:
MASADKNGSNLPSVSGSRLQSRKPPNLSITIPPPESQAPGEQDSMLPERRKNPAYLKSVSLQEPRGRWQEGAEKRPGFRRQASLSQSIRKSTAQWFGVSGDWEGKRQNWHRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPKIVDPLARGRAFRHPDEVDRPHAAHPPLTPGVLSLTSFTSVRSGYSHLPRRKRISVAHMSFQAAAALLKGRSVLDATGQRCRHVKRSFAYPSFLEEDAVDGADTFDSSFFSKEEMSSMPDDVFESPPLSASYFRGVPHSASPVSPDGVHIPLKEYSGGRALGPGTQRGKRIASKVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHIIITLLVICTYGIAPVGFAQHVTTQLVLKNRGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIRKDQQIEQLVRRERDIERTSGCCVQNDRSGCIQTLKKDCSETLATFVKWQNDTGPSDKSDLSQKQPSAVVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQAQSNHTGLLHIDCKIKGRPCCIGTKGSCEITTREYCEFMHGYFHEDATLCSQVHCLDKVCGLLPFLNPEVPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPWIDNIAHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVLWLYIYPINWPWIEYLTCFPFTSRFCEKYELDQVLH
Protein: BTB/POZ domain-containing protein SR1IP1 (Protein ATSR1-INTERACTION PROTEIN 1) (Q66GP0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (Probable). Involved in disease resistance. Acts as a substrate adapter that recruits CAMTA3/SR1 for ubiquitination and degradation during pathogen infection. Acts as positive regulator of plant defense by removing the defense suppressor CAMTA3/SR1.
Interaction partners:
- Cullin-3A
- Calmodulin-binding transcription activator 3
- At5g65925
- NADH dehydrogenase iron-sulfur protein 5-B
- Peter Pan-like protein
- Histone deacetylase complex subunit
- Probable lysophospholipase BODYGUARD 2
- Protein SHI RELATED SEQUENCE 8
Sequence:
MSAKKKDLLSSAMKRTSEWISSQEVSSDVTVHVGEASFSLHKFPLMSKCGFIKKLVSESSKDSDSTVIKIPDIPGGSEAFELAAKFCYGINFDMSTENIAMLRCAAEYLEMTEEHSVENLVVRAEAYLNEVALKSLSSSITVLHKSEKLLPIAERVKLVSRCIDAIAYMTCQESHFCSPSSSNSGNNEVVVQQQSKQPVVDWWAEDLTVLRIDSFQRVLIAMMARGFKQYGLGPVLMLYAQKSLRGLEIFGKGMKKIEPKQEHEKRVILETIVSLLPREKNAMSVSFLSMLLRAAIFLETTVACRLDLENRMGLQLGQAVLDDLLIPSYSFTGDHSMFDTDTVQRILMNYLEFEVEGVRLSNNGVDLAGDMERVGKLLENYMAEIASDRNVSLQKFIGLAELIPEQSRVTEDGMYRAVDIYLKAHPNMSDVERKKVCSLMDCQKLSREACAHAAQNDRLPVQTIVQVLYYEQQRLRGEVTNDSDSPAPPPPQPAAVLPPKLSSYTDELSKLKRENQDLKLELLKMKMKLKEFEKESEKKTSSSTISTNPSSPISTASTGKPPLPRKSFINSVSKKLGKLNPFSITPYNGRGRTKPPKDRRHSIS
Protein: Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Q8VDZ4)
Organism: Mus musculus (Mouse)
Function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, fatty acid uptake, bacterial sensing or cardiac functions. Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins. Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2. Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2. Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes. Participates also in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane. Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis. Controls oligodendrocyte development by catalyzing STAT3 palmitoylation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:30605677}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Golgin subfamily A member 7
- Golgin subfamily A member 7B
Sequence:
MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLNVSPAVPIYNAIMFLFVLANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDGQITVKIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPDLSRYTGLRTHLSLATNEDSSLLGKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIADSSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTSPFLSARLAQQREAERHPRLLPTGPPHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLAGREEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLSKTPLGRPAVPRFGKPDGLRSRGLGSPEPGTTAPYLGRSISYSSQKAPSGVSETEEVALQPLLTPKDEVQLKTTYSKSNGQPKSIGSASPGPGQPPLSSPTRGGVKKVSGVGGTTYEISV