wanglab/gogpt-training-data huggingface dataset:
Protein: A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) (Q9UKA4)
Organism: Homo sapiens (Human)
Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.
Interaction partners:
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Ras GTPase-activating-like protein IQGAP2
- A-kinase anchor protein 1, mitochondrial
- Glycogen synthase kinase-3 beta
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- cAMP-dependent protein kinase type II-beta regulatory subunit
- cAMP-dependent protein kinase catalytic subunit gamma
- cAMP-dependent protein kinase type II-alpha regulatory subunit
- Iroquois-class homeodomain protein IRX-3
Sequence:
MATFRNNHMKTKASVRKSFSEDVFQSVKSLLQSQKELCSVTAEDCLQQDEHANLTEVTFLGFNEETDAAHIQDLAAVSLELPDILNSLHFCSLNENEIICMKNINKPLDISSDPLNQSHPSGMLCVMRVSPTSPRLRIDFIFSLLSKYATGIRYTLDTFLHQKHQLETTDEDDDDTNQSVSSIEDDFVTAFEHLEEEETSKPYNDGMNITVLRSQCDAASQTVTGHHLETHDLKILISSGQQKSLAKPSTSSVNVLGHKELPSVKTSVTTSISEPWTQRSFYRSSNASDKDSDLQKTFFSSSPAYSSESECSSPSPVIFLDEEGYQKSLKAKLELPKIPVMKDDIEDSDSEVSEFFDSFDQFDELEQTLETCLFNKDPVIGKSSQRKGHKHGKSCMNPQKFKFDRPALPANVRKPTPRKPESPYGNLCDAPDSPRPVKASREDSGLFSPIRSSAFSPLGGCTPAECFCQTDIGGDRIHENHDSVYYTYEDYAKSISCEVLGSVLRTHHTNTLSNINSIKHGENKTVTFKHGNLDQKNKSKNKSLMIKDSIQKFAADLVEKSFGSAFKDLQKGVSSCTNALYHLAIKLTSSVLQMAFDELRRQRAFSLKERAISGLANFLVSEALSNALKDLQYVKKQIFTNTVARFAADLAEELVFEGIMEVCQFSYPQTPASPQCGSFDFEDKVVKLYAKDLSESVIQEAFIELSQVDVTFTTKAAVSVSTDNIKYVSAESVVPSTQAVTFSPSFHNQAIMVTKPVQEYKKEYTVQQALFCTSGIVTSIPVPLAGSALLPYHISSTACQAKAHLSSDDSNSNGDSAQVHIATKNREEKAACLRNICLPSEHNPGNQNDFKPTNDDIEMQSSSKLPNDPAIISNFSAAVVHTIVNETLESMTSLEVTKMVDERTDYLTKSLKEKTPPFSHCDQAVLQCSEASSNKDMFADRLSKSIIKHSIDKSKSVIPNIDKNAVYKESLPVSGEESQLTPEKSPKFPDSQNQLTHCSLSAAKDCVPECKVSMVHGSSLETLPSCPAVTGQKSDLKESAKDQPLKKHNLNSTSLEALSFGQENPFPHSHTFSSTALTCVDGLHVEDKQKVRDRNVIPDTPPSTPLVPSRASSEWDIKKLTKKLKGELAKEFAPATPPSTPHNSSVGSLSENEQNTIEKEEFMLKLMRSLSEEVESSESGELPEVDVKSEHSGKKVQFAEALATHILSLATEMAASHLDNKIIQEPKVKNPCLNVQSQRSVSPTFLNPSDENLKTLCNFAGDLAAEVITEAEKIAKVRNCMLFKQKKNSCYADGDEDYKVEEKLDIEAVVHPREVDPFILSLPPSSCMSGLMYKYPSCESVTDEYAGHLIQILKQEGGNSELIMDQYANRLAYRSVKSGLQEAAKTTKVQCNSRMFPVPSSQVKTNKELLMFSNKEHHQEADKKRQSKRNEGYFCKNQTCERTLDPYRNEVSQLYSFSTSLVHSITKDAKEELTASLVGLPKSLTDSCLFEKSGYEEDNECHVTPELPKSLQPSSQNHRFYHSTGSLNGYGCGDNVVQAVEQYAKKVVDDTLELTLGSTVFRVSETTKSADRVTYAEKLSPLTGQACRYCDLKELHNCTGNSSQHFFRQGSLASSKPASNPKFSSRYQKSRIFHLSVPQIHVNLDKKAVLAEKIVAEAIEKAERELSSTSLAADSGIGQEGASFAESLATETMTAAVTNVGHAVSSSKEIEDFQSTESVSSQQMNLSIGDDSTGSWSNLSFEDEHQDESSSFHHLSESNGNSSSWSSLGLEGDLYEDNLSFPTSDSDGPDDKDEEHEDEVEGLGQDGKTLLITNIDMEPCTVDPQLRIILQWLIASEAEVAELYFHDSANKEFMLLSKQLQEKGWKVGDLLQAVLQYYEVMEKASSEERCKSLFDWLLENA
Protein: Unconventional myosin-VI (Unconventional myosin-6) (A0A1Y0BRN3)
Organism: Homo sapiens (Human)
Subcellular location: Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane, clathrin-coated pit {ECO:0000256|ARBA:ARBA00004600}.
Interaction partners:
Sequence:
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKKYMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGLVKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSEAELISDEAQADLALRSLDSYPVTSKNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYAQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQYLQNAIESRQARPTYATAMLQSLLK
Protein: Hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) (A0A140VJL2)
Organism: Homo sapiens (Human)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV
Protein: Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30) (Q9ERP3)
Organism: Mus musculus (Mouse)
Function: May bind and stabilize microtubules during myotubes formation.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10953002}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:10953002}. Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles.
Interaction partners:
- Titin
- Telethonin
- Nebulin-related-anchoring protein
- F-box only protein 32
- Obscurin
- Creatine kinase S-type, mitochondrial
Sequence:
MNFTVGFKPLLGDAHNMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHAKAEQHLMCEEHEDEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQRFETLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEGSSKLVESAIQSMEEPQMALYLQQAKELINKVGAMSKVELAGRPEPGYESMEQFSVSVEHVAEMLRTIDFQPGAAGDEEDDDMALDGEEGNAGLEEERLDVPEGSGLH
Protein: ELMO domain-containing protein 2 (Q8IZ81)
Organism: Homo sapiens (Human)
Function: Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.
Interaction partners:
- Surfactant protein A2
Sequence:
MFISLWEFFYGHFFRFWMKWLLRQMTGKCELQRIFDTYVGAQRTHRIENSLTYSKNKVLQKATHVVQSEVDKYVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDPKTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFYCYLVYEFDKFWFEEEPESIMYFNLYREKFHEKIKGLLLDCNVALTLKV
Protein: Anillin (F1QJH8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MDPFTEKLLERTRARRENLQKKMAERPTAANRPMAKRTREPLTDTNSVLSEPTIEKALPSSKPSPFKRRCSDENTFLAGEENKQPVAPQMTDPMTDQKPPLAPTTVRPIPVEQRSAPDMLPTRPPPETEKMVVCPPQSPAKRTDNVLRQKGLDGARETQKEAPTTFPSSMRSRLQRLAGQRQNWDSNGATEAVSESVVVSPLKSHNLDHPPATPTNSEVPVGRKGRLANLAATIGSWEDDLGHPPIRRDNAQAQPGTAYVRPPVSTVTSNSEQLQSARPTSHRPVNRGQQPAVYSPVKSTSVVPPSPQKTEFPQARWAQAVPSPVSSPLKIPPSTQPSSPLKSVTASPSSPHRGYVSQSPLKSHGQVDKLNFGAALNSSPAKPVLAPKPSAADDAVSRVRFTKDATPTQHRGPAATPGGVKSFLERFGERCQERNQNTPSMLGGPGHTSAASTPATPKFKLLQERLGGAQATSTTAALTEKQKMEREAELAQIRNRFQKGNMLRGKEDISEVKDDTENKEIELSLQSQTSLPLHDNKPSVHVPEVFNSPSKSIGKGMSCASSSPAKEIELKVEMPTVEEPEDVQEVDVVREIEMNVDASVNSEVINELFDGVLEESDEDADEDPLNISSMSLLAPLAETVAAVIKSPERKPMTSTPANSFLVKSSTPENPSRPSKFQRTRMLRADSSDSIDVLDEQQNQKLLYSIDAYRSTRVKSEPERPHVKQVIVRKEDVSQRMEMNGSSSHINIKQKMKMLTNEMNLQQTVIHQASQALNCCTDEEHGKGSQVEAEAERLLIIATERRAALKAELDRLKAEGPTAQKKSASSVPVDIGLPASKGSISLLELRLPLKADFICSSANKPECGNHYFFVMIRAGPENTVATPLSSTRTGLSGDALTFTTTFTLSDVSNDFEIDIEVYCLVQKRELNPDKRKKASKSKAITPKRFLNISKSNLQTPVMASPGGPNAVRTSSFVLVGSHKLTLASIGKNKFPLEKVPFLCPLEGHVYLKMQCEVGSRIEEKGFLTMFEDVSGFGAWHRRWCVLSGYCISYWTYPDDEKRKNPMGRINLANCTSRKVEPANREFCARPNTFELITVRPQREDDRETLVSRCKDTLCVTKNWLSADTKDERNLWMQKLNQILVDLRMWQPDSCYRPM
Protein: Speedy protein E6 (P0CI01)
Organism: Homo sapiens (Human)
Interaction partners:
- M-phase inducer phosphatase 3
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase 1
- Speedy protein E1
Sequence:
MDRTETRFRKRGQITGKITTSRQPHPQNEQSPQRSTSGYPLQEVVDDEMLGPSAPGVDPSPPCRSLGWKRKREWSDESEEEPEKELAPEPEETWVVEMLCGLKMKLKQQRVSSILPEHHKDFNSQLAPGVDPSPPHRSFCWKRKMEWWDESEESLEEEPRKVLAPEPEEIWVAEMLCGLKMKLKRRRVSLVLPEHHEAFNRLLEDPVIKRFLAWDKDLRVSDKYLLAMVIAYFSRAGFPSWQYQRIHFFLALYLANDMEEDDEDSKQNIFHFLYRKNRSRIPLLRKRWFQLGHSMNPRARKNRSRIPLLRKRRFQLYRSTNPRARKNRSRIPLLRKHRFQLYRSMNSRARKNRSQIVLFQKRRFHFFCSMSCRAWVSPEELEEIQAYDPEHWVWARDRAHLS
Protein: Endoribonuclease antitoxin GhoS (EC 3.1.-.-) (Antitoxin GhoS) (P0AF61)
Organism: Escherichia coli (strain K12)
Function: Antitoxin component of a type V toxin-antitoxin (TA) system. Neutralizes the toxic effects of toxin GhoT by digesting ghoT transcripts in a sequence-specific manner. In concert with GhoT is involved in reducing cell growth during antibacterial stress. Overexpression leads to transcript level reduction of 20 other mRNAs involved in purine or pyrimidine synthesis and transport. Not seen to bind its own promoter DNA.
Interaction partners:
- Toxin GhoT
- Uncharacterized protein YjdI
- mRNA interferase toxin MqsR
- Cytoskeleton bundling-enhancing antitoxin CbeA
- Antitoxin MqsA
- Cytoskeleton-binding toxin CbtA
Sequence:
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDIDFDLNIMTVDDYFRQFYK
Protein: Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6) (Q9ER75)
Organism: Mus musculus (Mouse)
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Interaction partners:
- Iroquois-class homeodomain protein IRX-1
Sequence:
MAFSPFGHPYGSTSQFLVSASSSATCCETAPRPVSDVASASTSASTLCCTPYDSRLLGSARPELGAALGIYGAPYAAAQSYPGYLTYGPEPPTLCGALNPQYEFKDAAGSFAPSLTQPGAYYPYETTLGQYQYDRYGGVELSSAGRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKADSGEDSLGCLNGDTKDATASQEARGLRLSDLEDLEEEEEEEEAEEEAAVSAARRLADFQKSTQPLPAPCAAAQERCLESRECGLGLPRFSFTEAPQSGEADFITAEPGGPTMILHYPSGHKPRIWSLAHTAAASAVESAPSTPPRAQSPECHMIPRQPSSIRRLLVPRDSEGEEDSPAAKAFGNSTFTLQGLPLNCAPYPRRREPEVRFQYPSGAEG
Protein: Membrane-associated protein VP24 (Marburg VP24) (mVP24) (P35256)
Organism: Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980))
Function: May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding. Unlike Ebola VP24, mVP24 has no measurable impact of host dendritic cell function.
Subcellular location: Virion membrane {ECO:0000269|PubMed:16227263}; Peripheral membrane protein {ECO:0000269|PubMed:16227263}. Host cell membrane {ECO:0000269|PubMed:16227263}; Peripheral membrane protein {ECO:0000269|PubMed:16227263}; Cytoplasmic side {ECO:0000269|PubMed:16227263}. Host endomembrane system {ECO:0000269|PubMed:16227263}; Peripheral membrane protein {ECO:0000269|PubMed:16227263}. Note=In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place.
Interaction partners:
Sequence:
MAELSTRYNLPANVTENSINLDLNSTARWIKEPSVGGWTVKWGNFVFHIPNTGMTLLHHLKSNFVVPEWQQTRNLFSHLFKNPKSTIIEPFLALRILLGVALKDQELQQSLIPGFRSIVHMLSEWLLLEVTSAIHISPNLLGIYLTSDMFKILMAGVKNFFNKMFTLHVVNDHGKPSSIEIKLTGQQIIITRVNMGFLVEVRRIDIEPCCGETVLSESVVFGLVAEAVLREHSQMEKGQPLNLTQYMNSKIAI
Protein: Ferritin heavy polypeptide-like 17 (Cancer/testis antigen 38) (CT38) (Q9BXU8)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MATAQPSQVRQKYDTNCDAAINSHITLELYTSYLYLSMAFYFNRDDVALENFFRYFLRLSDDKMEHAQKLMRLQNLRGGHICLHDIRKPECQGWESGLVAMESAFHLEKNVNQSLLDLYQLAVEKGDPQLCHFLESHYLHEQVKTIKELGGYVSNLRKICSPEAGLAEYLFDKLTLGGRVKET
Protein: Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (O94238)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein eL33B
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein uL6A
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL6
Sequence:
MEGFKRYVEVGRVVLVTKGEYTGKLAVIVDIVDHKRALIDSPCSEFPRQVIRYGSVVLTHIVMKLPRGARSGIVAKKWKAQDVCNKWASSAWAKKLEAKKVRSQLNDFDRFAVMRLKKQRREQVNVAVAKALKA
Protein: Serine/threonine-protein kinase SRK2H (EC 2.7.11.1) (OST1-kinase-like 9) (SNF1-related kinase 2.5) (SnRK2.5) (Q9FFP9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Probable protein phosphatase 2C 24
- Probable protein phosphatase 2C 78
- Protein phosphatase 2C 3
- Protein phosphatase 2C 37
- Protein phosphatase 2C 16
- Probable protein phosphatase 2C 75
- Protein phosphatase 2C 56
- Protein phosphatase 2C 7
- Protein phosphatase 2C 77
- ABSCISIC ACID-INSENSITIVE 5-like protein 5
Sequence:
MDKYEVVKDLGAGNFGVARLLRHKETKELVAMKYIERGRKIDENVAREIINHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEAEARYFFQQLICGVDYCHSLQICHRDLKLENTLLDGSPAPLLKICDFGYSKSSLLHSRPKSTVGTPAYIAPEVLSRREYDGKHADVWSCGVTLYVMLVGGYPFEDPDDPRNFRKTIQRIMAVQYKIPDYVHISQECRHLLSRIFVTNSAKRITLKEIKKHPWYLKNLPKELTEPAQAAYYKRETPSFSLQSVEDIMKIVGEARNPAPSSNAVKGFDDDEEDVEDEVEEEEEEEEEEEEEEEEEEDEYEKHVKEAHSCQEPPKA
Protein: BLOC-3 complex member HPS4 (Hermansky-Pudlak syndrome 4 protein) (Light-ear protein homolog) (Q9NQG7)
Organism: Homo sapiens (Human)
Function: Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38.
Interaction partners:
- BLOC-2 complex member HPS3
- BLOC-2 complex member HPS6
- BLOC-2 complex member HPS5
- BLOC-3 complex member HPS1
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Dysbindin
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- AP-3 complex subunit beta-1
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Biogenesis of lysosome-related organelles complex 1 subunit 2
Sequence:
MATSTSTEAKSASWWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISDSPPTLVRLRKLKFAIKVDGDYLWVLGCAVELPDVSCKRFLDQLVGFFNFYNGPVSLAYENCSQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKVEPLLLLKAARILQTCQRSPHILAGCILYKGLIVSTQLPPSLTAKVLLHRTAPQEQRLPTGEDAPQEHGAALPPNVQIIPVFVTKEEAISLHEFPVEQMTRSLASPAGLQDGSAQHHPKGGSTSALKENATGHVESMAWTTPDPTSPDEACPDGRKENGCLSGHDLESIRPAGLHNSARGEVLGLSSSLGKELVFLQEELDLSEIHIPEAQEVEMASGHFAFLHVPVPDGRAPYCKASLSASSSLEPTPPEDTAISSLRPPSAPEMLTQHGAQEQLEDHPGHSSQAPIPRADPLPRRTRRPLLLPRLDPGQRGNKLPTGEQGLDEDVDGVCESHAAPGLECSSGSANCQGAGPSADGISSRLTPAESCMGLVRMNLYTHCVKGLVLSLLAEEPLLGDSAAIEEVYHSSLASLNGLEVHLKETLPRDEAASTSSTYNFTHYDRIQSLLMANLPQVATPQDRRFLQAVSLMHSEFAQLPALYEMTVRNASTAVYACCNPIQETYFQQLAPAARSSGFPNPQDGAFSLSGKAKQKLLKHGVNLL
Protein: Aspartic proteinase yapsin-7 (EC 3.4.23.-) (Q06325)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Single-pass type I membrane protein {ECO:0000269|PubMed:14562095}.
Interaction partners:
- Putative uncharacterized protein YCR095W-A
Sequence:
MTCLILWYLWLISTFQLEFATASTANTTTTAKSGTSSSTEEPFPVLAVGKDGRGNYYVNSTFGTPGQRQRLLVDIIQPYINLVSGTSESHNEYSGVYHKHPSYLMNDSTSSVPVSPGQIYEISFIDGRAVNCTLVTDDMNFTNVSSENSSTALITDLMVTRDNVQFNSGSLSISNVSFFDIQSSNFKTSGLLGLSGKVTNPGNAIDSSQYTEQSYFLSLLKDADIIESSSYSLWLAGDTSTYKTYRDPISNCGKLLLGGVDPSLFTGTLGKFDLIPYVDPVSNAVSVGYPIVPLGPIYIVSNSGQSLNMTSKDFLSPALLDSTSSVSYLPTSTIIQIAVQIAATYVESLDRWLVQCSIADMGVSLGFRLRELTIEIPLRDLLSSTYDTSTNSSMFFSSGQEACFLTLYANTNTGVNILGEAFIKNIYMAMDLEDNTIAIAQAKKVEDDAVTEETNETTASTIIKKIKSGYIPYAKVMNSSNTRNLTLYPSYRSGYMFTVPGQLTAAYSNGVITGAGRSFYDTSRASTSARPSSTQFDSFSVSASEEWSNSTNRTSSASGAGVRLSSPYTFNKDPAGHVTRIASLLLLSIFSILIVL
Protein: Protein-tyrosine-phosphatase IBR5 (EC 3.1.3.48) (Protein INDOLE-3-BUTYRIC ACID RESPONSE 5) (Protein IBA RESPONSE 5) (SKP1-interacting partner 33) (Q84JU4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the transduction of auxin and abscisic acid (ABA) signaling pathways. Dephosphorylates and inactivates the MAP kinase MPK12.
Subcellular location: Nucleus {ECO:0000269|PubMed:19000167}.
Interaction partners:
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 6
- Protein-tyrosine-phosphatase PTP1
- NEDD8-activating enzyme E1 regulatory subunit AXR1
- Protein TRANSPORT INHIBITOR RESPONSE 1
- Mitogen-activated protein kinase 3
- F-box protein SKP2A
- Auxin-binding protein 1
- Auxin transporter protein 1
- F-box protein At3g17710
Sequence:
MRKRERENPCSICGHYHKYEEGEVCGVCGHCMPVSSDTVAPQQVHVSAFPSEILPEFLYLGSYDNASRSELLKTQGISRVLNTVPMCQNLYRNSFTYHGLDNEKVLQFDDAIKFLDQCEKDKARVLVHCMSGKSRSPAVVVAYLMKRKGWRLAESHQWVKQRRPSTDISPEFYQQLQEFEQGIFGSEMMSAMNINDAPTFGFGFPKIDNQAQAPVFNNAPTSSIFSSPASSIPPQEFTFGATPPKPTTGGDIAMDGS
Protein: Tetraspanin-8 (Q8S8Q6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the regulation of cell differentiation.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}.
Interaction partners:
- Tetraspanin-16
- Arabidiol synthase
- DEAD-box ATP-dependent RNA helicase 37
- DEAD-box ATP-dependent RNA helicase 11
- DEAD-box ATP-dependent RNA helicase 52
- Vacuolar protein sorting-associated protein 51 homolog
- At5g04750
- Putative syntaxin-24
- Probable CCR4-associated factor 1 homolog 11
- Mitochondrial uncoupling protein 4
Sequence:
MARCSNNLVGILNFLVFLLSIPILAGGIWLSQKGSTECERFLDKPVIALGVFLMVVAIAGLIGSCCRVTWLLWVYLFVMFLLILLVFCITVFAFVVTNKGAGEAIEGKGYKEYKLGDYSTWLQKRVENGKNWNKIRSCLVESKVCSKLEAKFVNVPVNSFYKEHLTALQSGCCKPSDECGFEYVNPTTWTKNTTGTHTNPDCQTWDNAKEKLCFDCQSCKAGLLDNVKSAWKKVAIVNIVFLVFLIIVYSVGCCAFRNNKRDDSYSRTYGYKP
Protein: Sec-independent protein translocase protein (Q8HCQ4)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- Cytochrome c biogenesis Fc
- Cytochrome c biogenesis B
Sequence:
MPKMHLSFELLIEWNFALETFLGEVRIRFVWILIGLGLTWFTCYWFSEELIFLLAKPFLTLPLDSYFVCTQLTEALSTYVATSLIACSYFVFPLISYQIWCFLIPSCYGEQRQKYNRFFYLSGFCFSLFLFLTLSWVVPNVWHFLYFVGATSTNLLMIKLQPKIYDYIMLTVRILFISSVCSQVPVIVICLLELRGLSVETFTSNRRFLMVFSLITAALSTPPDIWCQIVASFFIYSIIEFAIFVALIVQVREEGWTIRMRGSIEKKEE
Protein: Leishmanolysin-like peptidase (EC 3.4.24.-) (Invadolysin) (Q9VH19)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for the coordination of mitotic progression, and also plays a role in cell migration.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15557119}. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells. {ECO:0000269|PubMed:15557119}.
Interaction partners:
- Prolyl 4-hydroxylase alpha subunit domain-containing protein
Sequence:
MAKTPPLRPHGNMAKFLAALGICSWLLVSATAHNCQHQHPKAHEVVHGVRIQLADSEDDSAGDPARHSVRRRSVAAEQPLRILLVYDESVYRLEEEKFNLINDTVLPEAVQFWEQALMVRETKGVIRLNRKCDSTQVYVKNGHTHCIDHCKATTMCGEVQVPDAHLDVCRVCNATGQNCRIDSNTQPGEGIENADFVFYVSARQTQRCFKGLTVAYAAHCQQEAALDRPIAGHANLCPESISTKPQELQTLISTVKHEILHALGFSVSLYAFFRDDDGKPRTPRKLDTGKPYLNEKLQIHQWSNETIRKVVRENWSVRGGHVNKVVDMMVTPRVIAEVRAHFNCNKLEGAELEDQGGEGTALTHWEKRILENEAMTGTHTQSPVFSRITLALMEDSGWYRANYSMATPLTWGKGLGCAFAMRSCKDWIQYNHARGRSIHPFCSKVKQDPLQTECTDDRNSVALCNLIRHEFELPKGYQNFDSLNHVKDGEEGFYGGSVSLADHCPYIQEFTWRSKNVIVRGSHCRFTENNPRPEKNFALESYGEGAKCFDHSESMWEERSCHQTREWQHWGSGCYKYDCFDGRLHILVGNYSYKCSFPGQKLSIRIAANGWLHKGAIMCPPCHELCGAQFAAQGKQCRPGEEPDPLNKYPRDNLACGAGSEKSRSVAIITAVLLLFGLRWGFS
Protein: histidine kinase (EC 2.7.13.3) (Q1CWW4)
Organism: Myxococcus xanthus (strain DK1622)
Interaction partners:
- histidine kinase
- Response regulator
- Response regulator
- histidine kinase
- histidine kinase
- histidine kinase
- Response regulator
- DNA-binding response regulator PhoP2
- Sensory/regulatory protein RpfC
- histidine kinase
Sequence:
MSQDGIPTMVPLQGGGIPFSRGATVASRVALTSPRISDEAPHRQAKAVSDTPAVLLVDDHVSNLVSLEAILEPLGIRMDKACSGEQALRFLLREDYAVILLDVRMVGLSGFETAALIKQRERTRNVPIIFLTAYGRDDAELVTGYATGAVDFLQKPFPPEVLRSKVSVFVELFRAQQQVRRQSELLRQKEAEARDAALRAAGYIDRLRDFTARLSEAATVPQVCRALFEQGLVAAGAKAGTVNLLDAEGEALEVVDAIGYPESVLSRWRRIPMTAAMPLVESLREQQAIWVGSPEEWSARYPLMDTRGLHEAALALPLLVKGRALGAIGLSFARPRTFTEMDRAFFTALAHACAQALDRVHLTAEERRAHSVARAAAARLQMLTEASDAFDATNRDLSVLLDTITRQVAYFLGDTCTLCLLSDDGTRLEVAASHSNQGEDGAPLLPGEGLSDFVLRGGRPLLVPELSEDQKRELGQGEALRSLLCVPLRTQGRVVGTLSVGRMGPGRSFTQEDQELVEELAAKAALSIENARLFAEQQRSQEELRRRAEFEQQLVGIVSHDLRNPLAAISMSAGLLEKKGALTEPQKRMVWRIGQATERAARMIRDLLDFTKARLGGGIALHRQTTDLREVVHQVVDELLVANPGRRVEVEVQGEVRGEWDSDRIAQVLTNLLGNALAYSPADAPVRVDTRLEGEAALLSVFNGGAPIPRELLPRLFEPLTRGALKEGQSTRSIGLGLYIVQDIVRGHGGGVEVVSSEQHGTTFTVRLPRAAG
Protein: Mup1p (Q5A3J0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
- cystathionine gamma-lyase
Sequence:
MGFTDLYKPSESPEKRSDTNTDNLSEYSTDHEIEAGVQLDQNVKQIGIISATFLIINRCIGAGIFATGSTIYTLSGSVGTSLILWVAGTLIAFAGLLVYMEFGSVLTRNGSEVVYLQHIYKSPRFLVISSYAVYALTMPWTAGNSVVTGEYILTAAGKEVTQWNSRGIALAVVTFAFLINAINAKAGLFMANTLGSFKIVIILFIIITGWVGLGNGIKTGHFEPTHNFHNAFEGQTPTGYGICVALYNVIWSFVGYSNASYALGEVKNPMKVLKVSAPLALLGIAIAYMLVNIAYYAVVPVDVIAASKRILVADFFYYAFGSKASKAAAVFVALSAWGNVMSVIFSQGRIITQLGRSGVIPFSRFFGSSKPFNTPFTGLLEHWIIGVIFICAVPPGDSYNFILNLVSYPLNVINTLLGAGLVWIYIRKYQGKYEWNPKIKATFPVAVFFFLSSLYLVAAPYIPPSEGQSVYEKLPYWLHAVVTWGVFGLGGIYWVIWTQLLPRFGGYKLVEKEVLGEDGFWRNKIYKVSKDSTEEEIQQQVEAAVEAEGNKLK
Protein: Basonuclin-2 (C7DZJ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MQFSTRPASAEPGFMGTWTQQSTDSNLLFRMSQQAIRCTLVNCTCECFQPGKIHLRTCDQCKHGWVAHALDKLSTQHLYHPTQVEIVQSNVVFDISSLMLYGTQAVPVRLKILLDRLFSVLKQEEVLHILHGLGWTLRDYVRGYILQDAAGKVLDRWTIMSREEEIITLQQFLRFGETKSIVELMAIQEKEGQAVTVPSSKTDSGIRTFIESNNRTRSPGLLSHLENNSPSSIHHFENIPNSLAFLLPFQYINPMSAPMLGLPPNGLSIEQSGLRMREPNLPNQSDPVEASESEVSLSPFHSGQSPSRGVMGTLPNAIEPKTEPNRASPISPTPSTLQSQQPQTPTQQTQGQQQSSSLNNHQIHHHFEKNEQSKTITHSSFSSKMHRIRRMGATSRKGRVCCNSCGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMLRNNRDKDLIRSSSGTATPVISSTKSGFNLTSPGRPPLSFATPPLEPMIQSPLQSPLVFPSLKSVQPVQPVPPFYRTLLSPADLVSPPVSLPTSPILPTTANSTSLTDQQQMLAVSSLSMHVSETSPFSHRLPTNHSTQDSIILDPMPKKKPRKSSMPVKIEKEVIDVADDYDDKDEDDDDGDSCHHHHHQPSSIHNVNGNCNNNNNGSSSSSHHCGGSGHESPSHDEMSPSQALRGMLHPEQEECTGSHGGRGHGDLRCIDSFTSEDQDHERDFENESETSESKMLYRDELMDTDINQTALGKNMDKEHQGTEDDQHLRKDLDEHSHSPPSQHQPVIKIKEEINDPTYDMFCMGQYSLYNGGMAAAAAAAASMAALHESFISSMSYGTSTPKFPSQSPEGDLCSSPDPKICYVCKKSFKSSYSVKLHYKNVHLKEMHVCTVSGCNAAFPSRRSRDRHSSNINLHRKLLTKELDDIVLDPQLTTLPKQLRAEFLSKIYADHHTGLEGVGGFDNGPPQSRGHEGMRSQVAREYSHSNGYCHGPNDDYVVLDLSTASSVQSSGSVQSSHESDEGSDEGILLDDLEDASDTEDCTPSTGAQRLSMEGKNREEAGKEEREGETDERILHYDPSVSPSILASSGGNGTGGILCTICHKLYSNKGTLRVHYKTVHLREMHKCKIPGCNMMFSSVRSRNRHSQNPNLHKKAPYTTMID