Protein: Nuclear pore complex protein Nup154 (154 kDa nucleoporin) (Nucleoporin Nup154) (Tulipan) (Q9V463)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the nuclear pore complex. Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope. In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad. Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells. Has a role in female fertility including egg chamber development; in nurse cells, has a role in the organization of F-actin in subcortical and cytoplasmic actin filaments important for the transfer of cytoplasm from nurse cells to the growing oocytes. Has a role in male spermatogenesis and fertility. Has a role in germ line cell proliferation.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:17410542}. Chromosome {ECO:0000269|PubMed:22718353, ECO:0000269|PubMed:9732281}. Nucleus {ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:9732281}. Nucleus membrane {ECO:0000269|PubMed:17277377, ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:22718353, ECO:0000269|PubMed:9732281}; Peripheral membrane protein {ECO:0000269|PubMed:17410542}; Cytoplasmic side {ECO:0000269|PubMed:17410542}. Nucleus membrane {ECO:0000269|PubMed:17277377, ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:22718353, ECO:0000269|PubMed:9732281}; Peripheral membrane protein {ECO:0000269|PubMed:17410542}; Nucleoplasmic side {ECO:0000269|PubMed:17410542}. Cytoplasm {ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:22718353}. Note=Increased localization to chromatin before interphase (PubMed:22718353). Distributed along filamentous structures that extend radially on the nuclear side of the pore complex (PubMed:17410542). {ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:22718353}.
Interaction partners:
- Nuclear pore protein
- Nucleoporin Nup188
- Nuclear pore glycoprotein p62
- Nucleoporin Nup35
- Nuclear pore complex protein Nup98-Nup96
- Nuclear pore complex protein Nup205
- Nuclear pore complex protein Nup214
- Nucleoporin seh1
- Nuclear pore complex protein Nup107
- Nuclear pore complex protein Nup153
Sequence:
MTLPQAQLDFFTTATSMLEWHYNLERNKPGLLELTGVSQHGRATMSGLNDYDYQSLSFLKSDRTHNLQQMRTVTKSAIPNEILEHFKHIKCHCTMGLFPEIGRAWLTIDSEIYIWTFNQTRDVAYYDGLSHLIVSVGLVKPKPGVFVQDVKYLLVLTTPIEVIVLGVTFGESSYNEMQLMNRPVFVIGTDNVSISVIKGTDDGRIFLGGRDGCLYEIYYQAESSWFGKRCKKINLSQGLVSYMVPSFLKVFSEVDPIEHIEIDNSRKLLYVLTEKGVIEAWDISTSYTTARRLGRITQNDITNQAVSLITTVDPSIFKSVKAICPLSADDADKLHLVAVTQCGVRLFFSTTSLNVKQQFGPAVPCSPGENTGFGQPAVQPPLSPNAEAPKGLYLLHVRLPPGYTPNATTNKPKQVHAAHYTEGTMLMITTQQHEQDLLWSLSSAPSVNFTYLVESTALESLDGVVWGLAEVHEPSTPQRKSPLNSARHARKVALLTNQGTHIIEVLKMVDVLRQILLSCNGPHHEEVKMFFQSQNQREACVTALLLATSDTYRGSDVALWAAQAFMLYGGEPCYQHQKFLNASNRNMANQTLGPNTTNVRERQSMFMSTPMPNSVANSPVGFPGSQFNQPISPIGNMQPPQVAVSNENSPIVFSAKHDGLYMYVSRMLHSVWQMRCVNEQFCSNLSQSECALLLSDLRSLRSFLEVHSVHDISSTTRVSFDNHLDRTNSYNTIMMGNTLLPIPEQRVLSEQAQVEETRSLSALNLFVKHACEVISLWNILNSHSFQLICVQLSPEHQKLLTCSTFRDLLITRSEVCAFLIISLINLYLKDAAGVSEVSKNLRENCPNLYRHEDDVTYKATELLMNAKNCTSATEKEHMLRTTLHMCKEAAPTLPLHSICMQFISADFFEGVIELSAVCASKSDPEEVGVHFYNNGEPADDREGYTCFATRMAYYKEVQLMLDHIYQRVCNKTHVQDKSINPLKGTAKASDAKNGATQTIPKIVAHTLKVKDPLIHITLYEWLLAHDMLKELLDVVEPSLGEFLRRSVSQNVDNVVLIDLLWKYYEKNSHHSQAAHILDNLAMTRSENINLEQRIEYLVRAVMCMRNGNVGSSLSNGIFLKELEDKLDIARVQKSVLAAMTELASDKLEAATAVKELNYALYDITQLYQHFAEPFDLWECQLSILNCSHHNDPLLIESVWGQIINSVVDKPGTTSERCNRLFTKIEILVREYGESGVCFPFAFLIRELEVKACQLRFPEGIVPEKLVSMNLDIELLLEYYSRMISMNERVWANEGNEWHLIQSVIRVVSLLADNAQSIWYRSKRRIVGKAQDIVAGCLNICYQKPDTNRLQHSLKELQSQLQRLLI