wanglab/gogpt-training-data huggingface dataset:
Protein: Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) (P21860)
Organism: Homo sapiens (Human)
Function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:33497358}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Interaction partners:
- Growth factor receptor-bound protein 2
- Pro-neuregulin-2, membrane-bound isoform
- SHC-transforming protein 1
- Pro-epidermal growth factor
- Receptor tyrosine-protein kinase erbB-4
- Epidermal growth factor receptor
- Pro-neuregulin-1, membrane-bound isoform
- Receptor tyrosine-protein kinase erbB-2
- Protransforming growth factor alpha
- Phosphatidylinositol 3-kinase regulatory subunit alpha
Sequence:
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT
Protein: tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1) (Q9QZI7)
Organism: Rattus norvegicus (Rat)
Function: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:10606267}. Cytoplasm {ECO:0000269|PubMed:10606267}. Note=Abundant in the nucleus.
Interaction partners:
- Phosphoseryl-tRNA kinase
- Selenocysteine insertion sequence-binding protein 2
- Similar to MJ0495-like protein SelB
- O-phosphoseryl-tRNA
- Pre-mRNA-processing factor 39
- U1 small nuclear ribonucleoprotein C
- Small nuclear ribonucleoprotein polypeptide A'
- Splicing factor U2AF subunit
- Eukaryotic translation initiation factor 4E
- Splicing factor 1
Sequence:
MAASLWMGDLEPYMDENFISRAFATMGETVMSVKIIRNRLTGIPAGYCFVEFADLATAEKCLHKINGKPLPGATPAKRFKLNYATYGKQPDNSPEYSLFVGDLTPDVDDGMLYEFFVKVYPSCRGGKVVLDQTGVSKGYGFVKFTDELEQKRALTECQGAVGLGCKPVRLSVAIPKASRVKPVEYSQMYSYSYNQYYQQYQNYYAQWGYDQNTGSYSYSYPQYGYTQSTMQTYEEVGDDALEDPAPQLDVTEANKEFMEQSEELYDALMDCHWQPLDTVSSEIPAMM
Protein: Adhesion G protein-coupled receptor V1 (A0A8I5ZNJ3)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MNVNQLAESLCSELGLYVFVVYFILHNQTCCPMKASYTVEMNGHPGPSTAFFTPGSGIPPAGEMNKSTQNLINAMEEVPSDWERVSFQQTSQASPDLKTSPQNGASFPSSGGYGQGSLIADEESQEFDDLIFALKTGAGLSVSDNESGQGSQEGGTLTDSQIVELRRIPIADTHL
Protein: Benzoate carboxyl methyltransferase (EC 2.1.1.273) (S-adenosyl-L-methionine:benzoic acid carboxyl methyltransferase) (Q9FYZ9)
Organism: Antirrhinum majus (Garden snapdragon)
Function: Converts benzoic acid into the volatile ester methyl benzoates. This scent, mostly produced in a rhythmical, diurnal manner, attracts the pollinators.
Interaction partners:
Sequence:
MKVMKKLLCMNIAGDGETSYANNSGLQKVMMSKSLHVLDETLKDIIGDHVGFPKCFKMMDMGCSSGPNALLVMSGIINTIEDLYTEKNINELPEFEVFLNDLPDNDFNNLFKLLSHENGNCFVYGLPGSFYGRLLPKKSLHFAYSSYSIHWLSQVPEGLEDNNRQNIYMATESPPEVYKAYAKQYERDFSTFLKLRGEEIVPGGRMVLTFNGRSVEDPSSKDDLAIFTLLAKTLVDMVAEGLVKMDDLYSFNIPIYSPCTREVEAAILSEGSFTLDRLEVFRVCWDASDYTDDDDQQDPSIFGKQRSGKFVADCVRAITEPMLASHFGSTIMDLLFGKYAKKIVEHLSVENSSYFSIVVSLSRR
Protein: Rop guanine nucleotide exchange factor 1 (AtRopGEF1) (Kinase partner protein-like) (KPP-like) (Rho of plants guanine nucleotide exchange factor 1) (Q93ZY2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. Acts downstream of PRK2 in the control of polarized pollen tube growth by activating ARAC11/ROP1. In association with ROPGEF4, acts as specific regulator of ARAC10/ROP11 function in ABA-mediated stomatal closure. May play a role in the Rac/Rop-signaling pathway that controls ROS-mediated root hair development.
Subcellular location: Cytoplasm, cytosol. Cell membrane {ECO:0000269|PubMed:16415208}. Note=Localizes to the apical region of the pollen tube plasma membrane to activate ARAC11/ROP1 and interacts with ARAC10/ROP11 on plasma membrane in guard cells. {ECO:0000269|PubMed:16415208}.
Interaction partners:
- Pollen receptor-like kinase 2
- Rac-like GTP-binding protein ARAC10
- Rac-like GTP-binding protein ARAC11
- Brefeldin A-inhibited guanine nucleotide-exchange protein 5
- Transducin/WD40 repeat-like superfamily protein
- Transducin/WD40 repeat-like superfamily protein
- Transducin/WD40 repeat-like superfamily protein
- Rac-like GTP-binding protein ARAC8
- Rac-like GTP-binding protein ARAC4
- AT3g15630/MSJ11_3
Sequence:
MGSLSSEEDDEVSSERCGSYSPSADISESESSSSFSCHRFDGEGASSSIPSSPRVVAGRGFYFPAPVMLPVIGGKDVVWDDKQPDNDLSEIEMMKERFAKLLLGEDMSGGGKGVCTALAISNAITNLSATVFGELWRLEPLAPQKKAMWRRELEWLLCVSDSIVELIPSIQQFPGGGTYEIMETRPRSDLYANLPALKKLDAMLIDMLDAFSDTEFWYTDRGIVLGDCDKDSYNSPASVRQEDKWWLPCPKVPPNGLSEEARKKLQQCRDFANQILKAALAINSGVLAEMEIPDPYLETLPKSGKECLGEIIYQYLTANKFSPECLLDCLDLSSEHQTLEIANRIEAAVHVWRQKNGRRHKKQAKLKLSSWGGKVKGLVNDNERNDFLVQRAETLLQSLRIRFPGLPQTTLDMNKIQYNKDVGQSILESYSRVMESMAFNITARIDDVLYVDDAMRRSISVTESLSLFSINGLNPQKAFSVQSSPHGSPFATPALSVASRSPRRAPPLYSVKRNGTREKGIVGETEKAWSYAGNLSSRRVTGVTPERD
Protein: Ferroxidase (A0A1D8PPC9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Interaction partners:
- High-affinity iron permease
- Fth1p
- Ftr2p
- Fth2p
- Cfl2p
- Siderophore transporter
- ferric-chelate reductase
Sequence:
MRATLTSLLVSITFLVSLVAAETHTWYFKTGWVNANPDGVYERPMIGFNDTWPLPTLRVKKGDRVQLYLINGFDNLNTTLHFHGLFQNGTNQMDGPEMVTQCPIPPGETYLYNFTVDQVGTYWYHSHTAGQYGDGMRGVFVIDDDDFPYDYDEDVVLTVGDHYHKYSSDIIPSFLSRFNPTGAEPIPQNFLFNETRNLTWKVEPGKTYLVRIVNVGGFVSQYLWMEDHEFTVVEVDGIYVEKNTTDMLYITTAQRYSVLINTKNSTDKNYAFMQRVDTDMLDVIPSDLQLNGTNYIVYNEDASLPEAYDVDSLDNYLDDFYLKPLSKEKLLDDADYTITVDVQMDNLGNGVNYAFFNNITYTTPKVPTLLTVLSAGDAATNELVYGTNTNSFVLQGGDVVDIVLNNLDTGKHPFHLHGHAFQLIERHKEIPEGEDPVTYNATDHADWPEYPMVRDTVYVRPQSYIVMRFKADNPGVWFFHCHIEWHLEQGLAFQLIEDPQGIQKNEKITDNHKQICEKVGVPWEGNAAANSKDYLNLVGENVQVKRLPTGFTAKGIVALVFSCISAFLGLAAISYYGMNDIENMEKRVARDLDVYFDDDDDDEEEEEQSITEQAATGSSSSPSNK
Protein: HIPL2 protein (Q94F08)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Interaction partners:
Sequence:
MAKTNQAITICSLLLLLLLSETTSHLLCSDSKTPVNNNETLQFCDSYKERSCCNSKDDLQLQNRFNSMNISDSNCSSLLKSILCSKCDEFSGQLFGDDDSSLVPILCNSTSQDLCSKLWDSCQNISIVSSPFSPTLLGGATSPSTSSNSSTLTDLWKSQTEFCTAFGGPSQTNNNKTKCFNGEPVNRDTSDDDEDDVKTPKGICLEKIGTGSYLNMVAHPDGSNRAFFSNQPGKIWLGTIPDQDSGKPMEIDESTPFVDITDQVSFDTQFGMMGMAFHPKFAENGRFFASFNCDKVKSPGCSGRCACNSDVNCDPSKLPKDDGTTPCRYQTVVSEYTANGTSSSPSTAKIGKASEVRRIFTMGLPYSSSHGGQILFGPDGYLYLMTGDGGGVSDTHNFAQNKKSLLGKILRLDVDVMPSVSEISKLGLWGNYSIPKNNPFQGNENEQPEIWALGLRNPWRCSFDSERPDYFLCADVGKDTYEEVDIITMGGNYGWRTYEGPYVFSPLSPFGENVSSDSNLTFPILGYNHSEVNKHEGSASIIGGYFYRSNTDPCSYGTYLYADLYANAMWAAIESPEDSGNFTDSLIPFSCSKDSPMKCTAAPGGASSGPALGYIYSFGQDNNKDIHLLTSSGVYRIVRPSRCNLACSKENTTASAGKQNPAGSAPPQPLPSSARKLCFSVFLLLSLLMMFLTLLD
Protein: RNA polymerase sigma factor, FecI family (Q4KED5)
Organism: Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Interaction partners:
- Sigma factor regulatory protein, FecR/PupR family
- Sigma factor regulatory protein, FecR/PupR family
- Sigma factor regulatory protein, FecR/PupR family
- Sigma factor regulatory protein, FecR/PupR family
- Sigma factor regulatory protein, FecR/PupR family
- Sigma factor regulatory protein, FecR/PupR family
- Sigma factor regulatory protein PupR
- Sigma factor regulatory protein, FecR/PupR family
- Sigma factor regulatory protein FecR
- Sigma factor regulatory protein, FecR/PupR family
Sequence:
MPADDLSLRCAVTDLYTHHHGWLQGWLRQRLGNAFDAADLAQDTFVRVLKARNAVEIREPRPYLSRIARGLLIDLFRRRSLEQAYLEALALVPEGEHPSPEEQSVLFQALMEVDRLLDGLGPKVKQAFLLSQCDGLTYEQIAERLQISVRSVSNYMAKAMEHCCLMQMRMQLS
Protein: MutS protein homolog him-14 (High incidence of males protein 14) (MutS protein homolog 4) (Q23405)
Organism: Caenorhabditis elegans
Function: Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Together with msh-5 and zhp-3 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair.
Subcellular location: Nucleus.
Interaction partners:
- MutS protein homolog 5
- Meiotic recombination protein spo-11
- DNA mismatch repair protein S5 domain-containing protein
- Crossover junction endonuclease MUS81
- Exonuclease 1
- Mismatch repair endonuclease PMS2
- DNA repair protein RAD51 homolog
- Zip homologous protein 3
- DNA topoisomerase 3
- RecQ-like DNA helicase blm-1
Sequence:
MYSNKSFQRRQRQQVAESRSEEKFSRSLVRLNAQSLLDSSGNNTTTKNVNSDVVIVVMEGRGSCEGHIGIALHDTCFPEIHLCEFVDSREYTTLKTMINVHEAFDIVIQNGNEERGSTKLLGEALMTAFPEASLQSISSKYFNSERGERQLQSLMNAEVSTVSEGCLRRTLALGALAVLLKYIHETRCVFFRVKSLRIKEMGVNDTCMIDFVSWESLEIVDADDASKARKFQMKQKRTLMSVLNHTVTTNGYRLLRSSVLQPSTDVYLIQSRQEAIEELIGKPQLKDKLRRTLSRAHELDRVIAMCIQTSTSWTVRESEAKINQIIKLMHTLKVIQGIRTLLHSAKMKSNILIEKTEFLKDPRFDQIMNILVEKVDDSLLDGKKNSLHLQNTKCYAIRHFVAVQLDLARQTYEEIIRNVEETGAREIAEYFHGNSSVRLSFSQSRGFHYTFVTRQAESVTIPRYFLDVFRNRTTVTFNSRKVIAYNDRLEQVVAEMFLASDVIVCDMIEEMQPMIPVLYYAMDALSSIDFLCGLATYSDLRDTCKPTFGPSFSISQGRHPILDWDDSEKTITNDTCLTRDRRFGIITGPNMAGKSTYLKQTAQLAIMAQIGCFIPANYASLPIFNRIFSRMGHNDELIRNKSAFASEMSDAAAIVQYADKNSLVVLDELARSTSTEEGIAITYAICEKVLKLQSYTFLATHFLDIAALANYSNAIDNYHFLPQTDENSTKKHKLLRGQYRGPLYGFELVELSTIPDEVIEHAQSLATELRANVEDTERDYDSERRRIKVYMNHRFRECAEYFMDTHGEKWKEEKEAIDKMKALRKYLVDELAKIDSQEQMCQ
Protein: DNA polymerase gamma (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (P15801)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the replication of mitochondrial DNA.
Subcellular location: Mitochondrion.
Interaction partners:
- Glycine--tRNA ligase 1, mitochondrial
- Glycine--tRNA ligase 2
- Triosephosphate isomerase
- Peptide methionine sulfoxide reductase
- DNA-directed RNA polymerase, mitochondrial
- ATP-dependent DNA helicase HMI1, mitochondrial
- DNA polymerase zeta catalytic subunit
- DNA primase small subunit
- ATP-dependent DNA helicase PIF1
- DNA replication ATP-dependent helicase/nuclease DNA2
Sequence:
MTKLMVRSECMLRMVRRRPLRVQFCARWFSTKKNTAEAPRINPVGIQYLGESLQRQVFGSCGGKDEVEQSDKLMELSKKSLKDHGLWGKKTLITDPISFPLPPLQGRSLDEHFQKIGRFNSEPYKSFCEDKFTEMVARPAEWLRKPGWVKYVPGMAPVEVAYPDEELVVFDVETLYNVSDYPTLATALSSTAWYLWCSPFICGGDDPAALIPLNTLNKEQVIIGHNVAYDRARVLEEYNFRDSKAFFLDTQSLHIASFGLCSRQRPMFMKNNKKKEAEVESEVHPEISIEDYDDPWLNVSALNSLKDVAKFHCKIDLDKTDRDFFASTDKSTIIENFQKLVNYCATDVTATSQVFDEIFPVFLKKCPHPVSFAGLKSLSKCILPTKLNDWNDYLNSSESLYQQSKVQIESKIVQIIKDIVLLKDKPDFYLKDPWLSQLDWTTKPLRLTKKGVPAKCQKLPGFPEWYRQLFPSKDTVEPKITIKSRIIPILFKLSWENSPVIWSKESGWCFNVPHEQVETYKAKNYVLADSVSQEEEEIRTHNLGLQCTGVLFKVPHPNGPTFNCTNLLTKSYNHFFEKGVLKSESELAHQALQINSSGSYWMSARERIQSQFVVPSCKFPNEFQSLSAKSSLNNEKTNDLAIIIPKIVPMGTITRRAVENAWLTASNAKANRIGSELKTQVKAPPGYCFVGADVDSEELWIASLVGDSIFNVHGGTAIGWMCLEGTKNEGTDLHTKTAQILGCSRNEAKIFNYGRIYGAGAKFASQLLKRFNPSLTDEETKKIANKLYENTKGKTKRSKLFKKFWYGGSESILFNKLESIAEQETPKTPVLGCGITYSLMKKNLRANSFLPSRINWAIQSSGVDYLHLLCCSMEYIIKKYNLEARLCISIHDEIRFLVSEKDKYRAAMALQISNIWTRAMFCQQMGINELPQNCAFFSQVDIDSVIRKEVNMDCITPSNKTAIPHGEALDINQLLDKSNSKLGKPNLDIDSKVSQYAYNYREPVFEEYNKSYTPEFLKYFLAMQVQSDKRDVNRLEDEYLRECTSKEYARDGNTAEYSLLDYIKDVEKGKRTKVRIMGSNFLDGTKNAKADQRIRLPVNMPDYPTLHKIANDSAIPEKQLLENRRKKENRIDDENKKKLTRKKNTTPMERKYKRVYGGRKAFEAFYECANKPLDYTLETEKQFFNIPIDGVIDDVLNDKSNYKKKPSQARTASSSPIRKTAKAVHSKKLPARKSSTTNRNLVELERDITISREY
Protein: B3 domain-containing transcription factor NGA4 (Protein NGATHA 4) (O82595)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates lateral organ growth. Functionally redundant with NGA1, NGA2 and NGA3.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Transmembrane protein
- At3g62990
- Copper transport protein family
- Hyperosmolality-gated Ca2+ permeable channel 2.1
- Heavy metal-associated isoprenylated plant protein 2
- Transcription factor IND
- Heavy metal-associated isoprenylated plant protein 31
- Transcription factor HEC2
Sequence:
MNISTMNLDQELAEIRASSSDHTNYFYSSERREHMFDKVLTPSDVGKLNRLVIPKQHAENFFPLEDNQNGTVLDFQDKNGKMWRFRYSYWNSSQSYVMTKGWSRFVKEKKLFAGDTVSFYRGYIPDDNAQPERRRKIMFIDWRPRAEINFVHNINNHNFVFGSPTYPTARFYPVTPEYSMPYRSFPPFYQNQFQEREYLGYGYGRVVNGNGVRYYAGSPLDQHHQWNLGRSEPLVYDSVPVFPAGRVPPSAPPQPSTTKKLRLFGVDVEESSSSGDTRGEMGVAGYSSSSPVVIRDDDQSFWRSPRGEMASSSSAMQLSDDEEYKRKGKSLEL
Protein: Small ribosomal subunit protein uS4z (40S ribosomal protein S9-1) (Q9LXG1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein eS26x
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein uS2z
- Large ribosomal subunit protein uL22y
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein uS5x
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS6y
- Large ribosomal subunit protein uL4y
- Small ribosomal subunit protein eS24z
Sequence:
MVHVCYYRNYGKTFKGPRRPYEKERLDSELKLVGEYGLRNKRELWRVQYSLSRIRNAARDLLTLDEKSPRRIFEGEALLRRMNRYGLLDESQNKLDYVLALTVENFLERRLQTIVFKSGMAKSIHHSRVLIRQRHIRVGKQLVNIPSFMVRLDSQKHIDFALTSPFGGGRPGRVKRRNEKSASKKASGGGDADGDDEE
Protein: Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (C9J8U3)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Interaction partners:
Sequence:
MMRVCWLVRQDSRHQRIRLPHLEAVVIGRGPETKITDKKCSRQQVQLKAECNKGYVKVKQFEEEAKNPGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHWTQ
Protein: C6orf25 protein (Megakaryocyte and platelet inhibitory receptor G6b) (B7ZLJ5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRFAPLVKTEPQRPVKEEEPKIPGDLDQEPVRAWGWEGDSQNL
Protein: E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (RING finger protein 75) (RING-box protein 1) (Rbx1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed] (P62878)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity). As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity). Probably also stimulates CDC34 autoubiquitination (By similarity). May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity). Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity). As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62877}. Nucleus {ECO:0000250|UniProtKB:P62877}.
Interaction partners:
- Cullin-2
- S-phase kinase-associated protein 1
- Elongin-C
- Ubiquitin-like protein NEDD8
- Cullin-7
- S-phase kinase-associated protein 2
- F-box/WD repeat-containing protein 1A
- Cullin-1
- DNA damage-binding protein 1
- Cullin-4B
Sequence:
MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
Protein: Small ribosomal subunit protein uS9z (40S ribosomal protein S16-1) (Q9SK22)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein uS2z
- Small ribosomal subunit protein eS6y
- Small ribosomal subunit protein uS12y
- Small ribosomal subunit protein eS21z
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein eS12z
Sequence:
MATQPATESVQCFGRKKTAVAVTHCKRGSGLIKLNGCPIELFQPEILRFKIFEPILLLGKHRFAGVNMRIRVNGGGHTSQVYAIRQSIAKALVAYYQKYVDEQSKKEIKDILVRYDRTLLVADPRRCEPKKFGGRGARSRYQKSYR
Protein: AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) (O88878)
Organism: Mus musculus (Mouse)
Function: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Subcellular location: Cytoplasm {ECO:0000250}.
Interaction partners:
Sequence:
MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPTSDSASVQRADAGLNNCEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVSEPVVTQPSPSVSQPSSSQSEEKAPELPKPKKNRCFMCRKKVGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI
Protein: SHUGOSHIN 1 (AtSGO1) (F4J3S1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protects sister chromatid centromere cohesion in meiosis I but not through the protection of the cohesin SYN1. Required with SGO2 for full protection of centromeric cohesion during anaphase I. Required to prevent precocious release of pericentromeric cohesins during meiosis. Not necessary for the maintenance of the synaptonemal complex (SC). Not required for monopolar spindle orientation in meiosis I.
Interaction partners:
- Protein PATRONUS 2
- Protein PATRONUS 1
- Separase
- Sister chromatid cohesion 1 protein 1
- TRF-like 10
- Serine/threonine-protein kinase haspin homolog
- Protein DOUBLE-STRAND BREAK FORMATION
- Separase
Sequence:
MVRATVLNVGDHASEGVRTNKAKGEKMVLEPPMNSAQRRKLGDITNLQNQKNLMNQGAKHQQQAILISSKENAENLQKENTKLMKVVMERDGIKSDLKKLRIEFQKVQEQNLLLAQANTRILAEFNTSKDQLKVLQHELGCKNGLVMARKMLLKEQTLPCTRHASKVKAQANACGGACKTFQPNDADHEHASGSSNANSLQRNEKANSKRRVSGRKNPANSEVLDIIGRSGETCQMEDNIDNKKLVSDSDNDAENHINDNVQSKRYCAGRQSSSSKTREASQTETLQKVVDAKEIKGDARFSLTKHSDWLKSQEPEPSESLYESRFPLRRRSARLKSQEPEPSESFHDSIETTKRRRSAIRSAMFNIQELGVIQNLNGLPDDQEIAAKARCSAREQSTGSKPEAVEPHDTKEIIGKSRISLRRQSARFNFQELGVTENLNGPHDDQTIAANARCCASEQSIGSKPEAVEPHDIEERIGKIRVSSRRQSANIETPRAIKEPANPPLHDDNVEESSQISCSVSMELKRESKKKPTGDESEEMRKTTVGRPSRQAAEKIKSYKEPSLKEKMRGGF
Protein: BEL1-like homeodomain protein 2 (BEL1-like protein 2) (Protein SAWTOOTH 1) (Q9SW80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that establishes leaf shape by repressing growth in specific subdomains of the leaf. Negatively regulates knox homeobox gene KNAT1/BP expression.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- Homeobox protein knotted-1-like 2
- Homeobox protein knotted-1-like 5
- Transducin/WD40 repeat-like superfamily protein
- Protein KNATM
- AAA-ATPase At5g57480
- Transcription factor bHLH52
- Homeobox protein knotted-1-like 1
Sequence:
MGITKTSPNTTILLKTFHNNSMSQDYHHHHHHNQHQGGIFNFSNGFDRSDSPNLTTQQKQEHQRVEMDEESSVAGGRIPVYESAGMLSEMFNFPGSSGGGRDLDLGQSFRSNRQLLEEQHQNIPAMNATDSATATAAAMQLFLMNPPPPQQPPSPSSTTSPRSHHNSSTLHMLLPSPSTNTTHHQNYTNHMSMHQLPHQHHQQISTWQSSPDHHHHHHNSQTEIGTVHVENSGGHGGQGLSLSLSSSLEAAAKAEEYRNIYYGANSSNASPHHQYNQFKTLLANSSQHHHQVLNQFRSSPAASSSSMAAVNILRNSRYTTAAQELLEEFCSVGRGFLKKNKLGNSSNPNTCGGDGGGSSPSSAGANKEHPPLSASDRIEHQRRKVKLLTMLEEVDRRYNHYCEQMQMVVNSFDIVMGHGAALPYTALAQKAMSRHFRCLKDAVAAQLKQSCELLGDKDAAGISSSGLTKGETPRLRLLEQSLRQNRAFHQMGMMEQEAWRPQRGLPERSVNILRAWLFEHFLHPYPSDADKHLLARQTGLSRNQVSNWFINARVRLWKPMVEEMYQQESKEREREEELEENEEDQETKNSNDDKSTKSNNNESNFTAVRTTSQTPTTTAPDASDADAAVATGHRLRSNINAYENDASSLLLPSSYSNAAAPAAVSDDLNSRYGGSDAFSAVATCQQSVGGFDDADMDGVNVIRFGTNPTGDVSLTLGLRHAGNMPDKDASFCVREFGGF