wanglab/gogpt-training-data huggingface dataset:
Protein: Transketolase (EC 2.2.1.1) (Q57YL8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Transaldolase
- Ribulose-phosphate 3-epimerase
- Glucose-6-phosphate isomerase
- fructose-bisphosphatase
- Pyruvate kinase
- Ribose 5-phosphate isomerase, putative
- deoxyribose-phosphate aldolase
- Fructose-bisphosphate aldolase
- ATP-dependent 6-phosphofructokinase
- Triosephosphate isomerase
Sequence:
MSFNDNLATNSIRCLAADGVQQAKSGHPGAPMGMAPIAYVLWSEVMKFDSKDPEWIDRDRFVLSNGHASMLQYVMLHLSGYDLSMDDLKKFRQLNSRTPGHPERGVTPGVEVTTGPLGQGIAQGVGLAIAEAQLAATYNRPGYNIIDHWTYVFCGDGCLMEGIGQEALSLAGHLGLEKLVVVYDSNRISIDGSTDIAFTEDAAKKYEALGFHVIPVSNGDSDFTALRAAFAECKQIKGRPKLVIVNTTIGYGCRLAGSEKAHGAPLGDDEVARVKEQFGLDPTKKFHVQPEVYGIFGKNAERGASRHEEWRVRMRKYTEEFPQEADALQNQLDFKLPPDWKSKLPLNDKSIATRKASENALGALLTLTPALVGGSADLSPSNLTRPGSAQMVDFQKDTPHGRYIRYGVREHAMCAVMNGMHAHGGFVPYGGTFLNFIGYALGAVRLASLAHHHVVYVATHDSIGVGEDGPTHQPVELLALLRATPNLLVFRPSDQTETSAAWALALENTRGPSILCLSRQNTVPQPTSKLEGVAKGAYILIPAEKPQLIIVSSGSEVSIAVDAAKALSSEVRTTVVSMPCQELFELQPVGYQQKVFPEGVPVISIEPFVSTGWERYSHYHIGMEGFGASAPADQLYEYFNITVNHAVEVGRKLAKKYVGGTAPAKRSHL
Protein: Solute carrier family 3 member 2 (F5GZI0)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MCRTPYISSSESRLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA
Protein: N-acylglucosamine 2-epimerase (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (F1RZU4)
Organism: Sus scrofa (Pig)
Interaction partners:
Sequence:
MEKERETLQAWKERVGQELDRVMAFWLEHSHDREHGGFFTCLGRDGRVYDDLKYVWLQGRQVWMYCRLYRKLERFHRPELLDAAKAGGEFLLRHARVAPPEKKCAFVLTRDGRPVKVQRSIFSECFYTMAMNELWRVTAEARYQPHRDPGHRGGSQPKRRAPSVRPSREKRQLVLKRPKLPSGFQGRVFKSQSEAVDMMDQIVHWVREDPSGLGRPQLPGAVASESMAVPMMLLCLVEQLGEEDEELAGRYAQLGHWCARRILQHVQRDGQAVLENVSEDGEELSGCLGRHQNPGHALEAGWFLLRHSSRSGDAKLRAHVIDTFLLLPFRSGWDADHGGLFYFQDADGLCPTQLEWAMKLWWPHSEAMIAFLMGYSESGDPALLRLFYQVAEYTFRQFRDPEYGEWFGYLNREGKVALTIKGGPFKGCFHVPRCLAMCEEMLSALLSRLA
Protein: LD30122p (VAMP-associated protein 33kDa, isoform B) (VAMP-associated protein 33kDa, isoform C) (VAMP-associated protein 33kDa, isoform E) (Q9W4N8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
Interaction partners:
- Oxysterol-binding protein
- LP10995p
- Synaptobrevin
- TAR DNA-binding protein 43
- Superoxide dismutase
- Phosphatidylinositol-3-phosphatase SAC1
- Mitochondrial fission 1 protein
- Steroidogenic acute regulatory protein-like
- Endoplasmic reticulum transmembrane protein
- Ceramide transfer protein
Sequence:
MSKSLFDLPLTIEPEHELRFVGPFTRPVVTIMTLRNNSALPLVFKIKTTAPKRYCVRPNIGKIIPFRSTQVEICLQPFVYDQQEKNKHKFMVQSVLAPMDADLSDLNKLWKDLEPEQLMDAKLKCVFEMPTAEANAENTSGGGAVGGGTGAAGGGSAGANTSSASAEALESKPKLSSEDKFKPSNLLETSESLDLLSGEIKALRECNIELRRENLHLKDQITRFRSSPAVKQVNEPYAPVLAEKQIPVFYIAVAIAAAIVSLLLGKFFL
Protein: TBC1 domain family member 17 (Q9HA65)
Organism: Homo sapiens (Human)
Function: Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR). Involved in regulation of autophagy.
Subcellular location: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24752605}. Cytoplasm {ECO:0000269|PubMed:22854040}. Recycling endosome {ECO:0000269|PubMed:22854040}. Note=In the presence of optineurin/OPTN, may be recruited to recycling endosomes. {ECO:0000269|PubMed:22854040}.
Interaction partners:
- Mitochondrial fission 1 protein
- TBC1 domain family member 15
- GABA type A receptor associated protein like 1
- Gamma-aminobutyric acid receptor-associated protein-like 2
- Gamma-aminobutyric acid receptor-associated protein
- Optineurin
- Ras-related protein Rab-7a
- Ras-related protein Rab-7b
- Coiled-coil domain-containing protein 121
- Ras-related protein Rab-8A
Sequence:
MEGAGYRVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQLCHSEPTRGAEPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEEDEGADS
Protein: T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Stem cell leukemia protein SCL) (xSCL) (O73823)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription factor that acts synergistically with lmo2 and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P22091, ECO:0000255|PROSITE-ProRule:PRU00981}.
Interaction partners:
Sequence:
MSLKMMERLSTDMDGTRDVASPPARQDAAEPERTVELSGVKEGAAPNSPPRAVPVIELLRRGEGLGNIKAREQELRLQNIRTTELCRATLTPATELCRAPLTPTTELCRAPLTPTTELCRAPLTPTTELCRPPLTPAAEFCRASLTPASELCRAPSSVTGPSLTATTELCRPPIPLPTPSTGPPAEQAVEARMVQLSPTASLPLQAAGRTMLYGLNQPLASDNSGYFGDPDTFPMYTSNSRAKRRPGPIEVEISEGPQPKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLDDQEEEGNQRNKGNKDNGMVQQELLQDMLSPNSSCGSSLDGAPSPDSYSEEHDALDSKHSRNLHQAMLPIDGSGQR
Protein: ADAM metallopeptidase with thrombospondin type 1 motif 3 (Q8BIB2)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MVFLSLWLIAASLVEVRTSADGQAGTDEMVQIDLPTKRYREYELVTPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEHLFFNVTAFGRDFHLRLKPNTHFIAPGAVVEWHETAPRPGNTTDPRNSHLHGSASEGSWRSEPLQTSCAYVGDIMDIPGTSVAISNCDGLTFEEDSSPWTSWLTVAFAKIAQNDLYLWSSLTFMPLPPSAKMAIACPHMLHFSQHQMVGF
Protein: Cytochrome c Snr1 (Q9HZH6)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Interaction partners:
- Probable permease of ABC transporter
- Probable binding protein component of ABC transporter
- Probable secretion protein
Sequence:
MKTPAWTRHALWVMPLALGLQSAVVAGDEQPSKTSSYSPVVINEDFATIMKRMTANKPSIEQAHKTLLEQRYDLSDRPAKGASMTRGKPLQEGIRVKLPAGTSWEELARLSPEEIRKQGLFPGGFLPLPHPNHAEGGMVFPKFLIDEIKRQESRDLTRFDLDYDLPDHFLPEFPAPMFLTTRPDLGDVSKGKLVTIDNYFELFNGILNPKQLEGLRLLLTAFPQQQFNLTDDRRSEHPSRGVACFDCHANGHTNAATHLAGDVRPQPFRHRIDTPTLRGVNIQRLFGSQRALKTVEDFTEFEQRAAYFDGDPVIATKKGVNVLERGSQVHFMGEFQALLDFPPAPKLDVEGRLDPGKASEQELRGEKLFYGKAACAGCHAPPYFTDNLMHNLKVERFYDPKLVNGVMASADGPIKTFPLRGIKDSPPYLHDDRLLTLEDTVEFFNLVLERKLSAEEKGDLVAYLRTL
Protein: Ribonuclease VapC4 (RNase VapC4) (EC 3.1.-.-) (Toxin VapC4) (VapC-mt4) (O07783)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4.
Subcellular location: Secreted. Note=Following 6 weeks of nutrient starvation. {ECO:0000269|PubMed:23345537}.
Interaction partners:
- Antitoxin VapB4
- Putative antitoxin VapB5
- Ribonuclease VapC26
- Ribonuclease VapC25
- 23S rRNA-specific endonuclease VapC20
- Ribonuclease VapC33
- Ribonuclease VapC31
- Ribonuclease VapC30
- Putative antitoxin VapB34
- Ribonuclease VapC32
Sequence:
MNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAWALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI
Protein: N(1)-aminopropylagmatine ureohydrolase (APA ureohydrolase) (APAUH) (EC 3.5.3.24) (Agmatinase) (EC 3.5.3.11) (Protein SpeB homolog) (Q5JI38)
Organism: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Function: Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the decarboxylation of N1-(3-aminopropyl)agmatine to yield spermidine and urea. It can also use agmatine to yield putrescine.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20675472}.
Interaction partners:
- Polyamine aminopropyltransferase
- Arginase
- Arginase
- Pyruvoyl-dependent arginine decarboxylase
- Universal stress protein
- Translation initiation factor 5A
Sequence:
MEFLYTYETLKLEFPLVEPEKARFILLGVPFDGTTSYKAGARFGPTLIRQATLNLESYILDYDLDIAELPIADIGDIAVVAGDPRKTADRVRETLEELKKANPKAIPILLGGEHSQTLGAVEALKPASYVVFDAHLDLRNSYEDNPYNHACVARRISELGVKEAIFGIRSGTKEEVDFARERDIPWVHARDYSFDAFVDLVEALPEPVYLSIDIDVFDLSMVPSTGTPEAGGLRFWEVVEAIEWLVEKKEIAGFDIMEVAGEKLGDPTALTAAKLLFYSIGAMAKFGR
Protein: Two-component response regulator (Q9AV93)
Organism: Zea mays (Maize)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR036392}.
Interaction partners:
Sequence:
MAAAEARGADFPVGMKVLVVDDDPTCLVVLKRMLLECRYDVTTCPQATRALTMLRENRRGFDVIISDVHMPDMDGFRLLELVGLEMDLPVIMMSADSRTDIVMKGIKHGACDYLIKPVRMEELKNIWQHVVRKKFNGNKDHEHSGSLDDTDRNRPTNNDNEYASSANDGGDGSWKSQKKKREKEDDETDLESGDPSTSKKPRVVWSVELHQQFVNAVNHLGIDKAVPKKILELMNVPGLTRENVASHLQKFRLYLKRIAQHHAGIPHPFVASASSAKVAPLGGLEFQALAASGQIPPQALAALQDELLGRPTSSLALPGRDQSSLRLAAIKGNKPHGEREIAFGQPIYKCQNNTYGAFSQSSPAVGGLPSFAAWPNNKLGMTDSSNTLGNVGNSQNSNMLLHELQQQPDTLLSGTLHNIDVKPSGVVMPSQSLNVFPASEGISHNQNPLVIPSQSPSFLASVPPSMKHESLLGSPSPSTSLLGGLDMVNQASTSQPLISSHGANLPGLMNRSSNAMPSPGISNFQSGNIPYVVNQNAMGVSSRPPGVLKTECTESLTHSYGYIGGSTSVDSSLLSSQAKNPQYGLLQSQNDVSSSWLSSQDFDSFGNSLGQGHPGSTSSNFQSSALGKLPDQGRGRNHGFVGKGTCIPSRFAVDEVESPTNLSHNIVNSGDIVNPDIFGFSGQM
Protein: Protein phosphatase 2C homolog 7, mitochondrial (PP2C-7) (EC 3.1.3.16) (P38797)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates and activates the ubiquinone biosynthesis protein CAT5/COQ7. Also dephosphorylates CIT1 on 'Ser-462', which leads to its activation.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11327310, ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:30267671}.
Interaction partners:
- [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
- [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
- SEC14 cytosolic factor
- Protein phosphatase 2C homolog 1
- Protein phosphatase 2C homolog 4
- Protein phosphatase 2C homolog 2
- Inner nuclear membrane protein SRC1
- Protein phosphatase 2C homolog 3
Sequence:
MFANVGFRTLRVSRGPLYGSCSQIISFSKRTFYSSAKSGYQSNNSHGDAYSSGSQSGPFTYKTAVAFQPKDRDDLIYQKLKDSIRSPTGEDNYFVTSNNVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENSSKETLLTPKKIIGAAYAKIRDEKVVKVGGTTAIVAHFPSNGKLEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEMLKEAERRGSKYILNTPRDADEYSFQLKKKDIIILATDGVTDNIATDDIELFLKDNAARTNDELQLLSQKFVDNVVSLSKDPNYPSVFAQEISKLTGKNYSGGKEDDITVVVVRVD
Protein: Protein GLC8 (P41818)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Modulator of GLC7 type-1 protein phosphatase.
Interaction partners:
- Serine/threonine-protein phosphatase PP1-2
- Type 1 phosphatases regulator YPI1
- UBX domain-containing protein 1
- Protein phosphatase 1 regulatory subunit SDS22
- PHO85 cyclin-6
- Aurora kinase
- Serine/threonine-protein phosphatase PP-Z1
Sequence:
MGGILKNPLALSPEQLAQQDPETLEEFRRQVYENTQKNAKLTSHKRNIPGLDNTKEEGEIIGTSSTFLPKDTLSLKHEQDMLAKMTPEERVQWNQRNLAENEITKKQFQDIHIDEPKTPYQGAVDPHGEYYRVDDDEDEDNSDKKPCQVANDDIDDLSLGEPEFEIKENKQPDFETNDENDEDSPEARHKKFEEMRKKHYDVRAIFNKKSREALKDEDEDEDDSTTKEP
Protein: Alanine--tRNA ligase (EC 6.1.1.7) (Protein lactyltransferase AARS1) (H3BPK7)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPIERLYVTYFGGDEAAGLEADLECKQIWQNLGLDDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDSKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEELRARGLEVTDDSPKYNYHLDSSGSYVFENTVATVMALRREKMFVEEVSTGQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGDLKVGDQVWLFIDEPRRRPIMSNHTATHILNFALRSVLGEADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMIEAAKAVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPSGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKKCLSVMEAKVKAQTAPNKDVQREIADLGEPCSRDPMDPVLGPWTFPAAPSAASRRALPKHALATAVIPQWQKDELRETLKSLKKVMDDLDRASKADVQKRVLEKTKQFIDSNPNQPLVILEMESGASAKALNEALKLFKMHSPQTSAMLFTVDNEAGKITCLCQVPQNAANRGLKASEWVQQVSGLMDGKGGGKDVSAQATGKNVGCLQEALQLATSFAQLRLGDVKN
Protein: Sterol uptake control protein 2 (Q59QC7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
Interaction partners:
- Lanosterol 14-alpha demethylase
- Delta
- Transcription factor TAC1
- C-8 sterol isomerase ERG2
- Squalene epoxidase ERG1
- Pleiotropic ABC efflux transporter of multiple drugs CDR1
- Multidrug resistance protein 1
- Sterol 24-C-methyltransferase
- C-22 sterol desaturase ERG5
- Delta
Sequence:
MMMTVKQESPNSTLNTSEFSSDENLKTNNSEPPKKVSKSSTGKRKYHQKSRNGCSTCKKRRVKCDEQRPVCGNCTKLKLDCGYLHEPLENILNTKKDIANNEPPSKKRKRKVSTVSAASDSESTTQQATPSLTPSPNHSQDIKTQPVIPPTNPLSALSSGLLSAGNLNNLNVAHLVNNLSGLGDLSNLASLGNLASLSNLASLAQLPIDLSNLGSLLDSPAASNIAASFLGSAAATTVPPTTNSEFKESNQRKSQTQMPPQPTVPITSMGAATTTSSHQQANMPSRSKPQPETLQSSIPATTSGSPGMSYPGCPSNSDPFGRSSDKSLPNISPNMSIPANPLSDPLTQGMRSNLNMLDLKLMFHYTSVVANTITGAGISDTNIWNCDIPKLAFEHPFLMHSILAFSATHLSRTEKGLDQCVTCHRGDALRLLREAVLNINADNTDALVASALILIMDSLANASFPSSTSPKSLPASAWIFHVKGAATILTAVWPLTEASRFYKFISVDLGDLGDIINQGVNMNKSKGIDRENSAYYTDLECHDADIADLFPVLLDSPYLITLAYLNKLHKERYKSDFILRIFAFPALLDKQFMGLLMSGDVKAMRIMRSYYKLLRSFTTEMKDKVWFLEGVSQVLPVNVEEYAGGAGGMHMMMDFLGGGPAIVDDNEIDAEITKFDPSGTLTNKLIDTDNLPSVLTSNLDLMQGDNGFMNMK
Protein: Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) (O00506)
Organism: Homo sapiens (Human)
Function: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15037601}. Golgi apparatus {ECO:0000269|PubMed:15037601}. Note=Localizes to the Golgi apparatus.
Interaction partners:
- Programmed cell death protein 10
- Serine/threonine-protein kinase 24
- Striatin-interacting protein 1
- Striatin-interacting protein 2
- MOB-like protein phocein
- Striatin
- Serine/threonine-protein kinase 26
- Striatin-3
- Striatin-4
- Suppressor of IKBKE 1
Sequence:
MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRNHLTSTR
Protein: Phosphatidylinositol 3-kinase (EC 2.7.1.137) (Q8I3V5)
Organism: Plasmodium falciparum (isolate 3D7)
Interaction partners:
- Serine/threonine protein kinase VPS15, putative
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- 1-phosphatidylinositol 4-kinase
Sequence:
MKIRYDKCSSTKDLNYFFHLKLGFFVCYKNHNDKYSFKNKILQKNDTILFFKKKKKFMYLRKKKKKKKKKILIQIIQEYNKYNEYFKYNSNLEGNQGFNKKPEKNKNTKGNVYTDHTNQNAKSKIYNYDMNDDSYSNYVNNNNVFRISSFLILNNEFFGYPLQFVCETEGRSRNHEHYPDVHGDNIKYNKCDDNKYNKCDDNKYDKCDDNKYNKCDDNKYDTCDDNKYDTCDDNKYDTCDDNKYNKYDDDKYDTCDDNKYNKYDDDKYNKYDDDKYNKYDDDKYEKSRKKKKLNNLYKTILTKKKRKKMNSNLCVINKIYKYPIKYCELNSKAFVFFIIKNVGVHKITYYSYNKLFSKDGVLNQGIQICKLYHVNKNKKIKQIIFEALKNKITFSYDNNPNNIKKKIYKFLKKNCAYHDLIKLFYFKGHKQREKCNKKLNMEKTFGVHKSSRYNYKTYKKKKKIDMCKNYCDDILDTYNSKYYKGELSGQHKHIKMTGEQKEEHHIKYTHLNFNHGKDETFYKELYKCNYIEKYISSVNYFLLERRRMFNKYKQQELCVNKNEENNKNKNDDDNKNDDDNKNDDDNNKNDDDNKNDDDDNKNDDDNKNDDDDNKNDDDDNNKNNIQCDNHSDNIYMCGTYGNMENYNVPHSTNNTNLQSIKKRIINMNILDNIRCNKTYKYIDKNKFKCFTYYSCKNYNVCKKIIEKYKLYKFLKKKKIEGYMILNFLNFNKELIYYNEHKKDMSTLHDNLFDVISNNQNENVKYNHICNNNKYDWFFNSFDYVGNLEESITCFNNHKKKENMKNIKNIKKKKKKNLFYNEQHNIKNNKNDYHFDKYPSSLYSHLTNKKMVNNTEVNNIKDENSLQMYIINKDVTKNKDGNLLLNSYYNSKLGKSINTCSKEIYKEEHKNVYIYNKKITKMNIKMKTEQKYICVDSKRNTRTYNSKNIRTYNSKNIRTYNSKNIRTYNRKNIRTYNRKNIRTYNRKNIRTYNRKNIRCNNRKKFHLNRNKKKNGCVKKYKLYDERNTLVYKNKIGSNHFFLKEEIGKSTKKLNDIFEHISNYTNRISKNINITNKNRYDDYPFDFLSKDKIEYISMLSPTINEIKTLNTILTIPLIKMNEYEKNCIWRFRFQLLNRKETLGKFLKSINWNNKEEEEEAIILLNKWAKPGIENCIELFYSHLHHYVIKKYIIDIIKNSKKEEIKLYLFQLVQSLRTFNYQHIDNLFINTLIQKCIKSKKLSIYFYWFLLSEAKDKIKGKLYLHIHKLFINKLMTSNIRKNKIILDILKNQNRFRNQLLYLTKIAKNKTDRIQNKTRKLRNFLFYYRTNYGYINIKDFIKNNIFISDHNVYDFLDICKMKRENSLDTPMRGDNIGQPSYLGMVPGMGKSTDDSKNVYGDDNKNVYGDDNKNVYGDDSKNIYCDDNKNVYGDDNKNIYGDDSKNIYGDDNKNIFSDDNKNLYSDNNNNKHIRYNKYVKNISYEHFNEYPYDNKKSRNIYTCNKDICNSIYYLDNELTINYDIKDDLYFFQYKRSSDEKLLNTDLSNDSNDMIHYIDDSKNVKIERNRDNSFFSNFLQFNDNLDFFLNATYSDEDNNYEILDDSINFVQKQKIKKIKTPLILPIDPNIELLSFLPEQSYVLRSSLYPIVIACLVRKKIKLYNENYNNLIINNHTFYKNDQNKDNIINNLSYDKSYHSYYNSQFIKTLQNSFESTTSLNYHYNFLKCSNNNIFYKNKKIERIKPNTSIQKAFPSNENILNRNQHVYYSNNQIVHNIKKMNKHKRDDYMINEKVLPCVSNSCLGDKLMPSHDKMRSSHDKMMPSHDKMMPSHDKLMSPHYTLMSSHDKPVAPSGVSSLGEKKSKDEKKNRKKYNEIYQLSIKKYIYKAGDDLRQDHLVIQIIYVMDNIWKRYGLDLKMTLYRVLALSTDDGFIEFVDYAESISSIKKNYKGEIRQYFIDNSTCSSSPLGFDTEILQNFISSCAGYSVITYILGIGDRHLDNLMVTKDGRFFHIDFGYIFGEDPKPFSPPMKLCKEMIEAMGGAHSIGYEQFLKKCCLAYKYLRYHSQLIISLLDAMCDAGLKDMKMSPELCVLKVQEKFRLDLNDEAAEIYFLSVINASVKTLFPVVVDKLHEWALNWK
Protein: Butyrophilin-like protein 1 (Q7TST0)
Organism: Mus musculus (Mouse)
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Perilipin-2
- Xanthine dehydrogenase/oxidase
Sequence:
MMKGSPSVPPAGCLLPLLLLLFTGVSGEVSWFSVKGPAEPITVLLGTEATLPCQLSPEQSAARMHIRWYRAQPTPAVLVFHNGQEQGEVQMPEYRGRTQMVRQAIDMGSVALQIQQVQASDDGLYHCQFTDGFTSQEVSMELRVIGLGSAPLVHMTGPENDGIRVLCSSSGWFPKPKVQWRDTSGNMLLSSSELQTQDREGLFQVEVSLLVTDRAIGNVICSIQNPMYDQEKSKAILLPEPFFPKTCPWKVALVCSVLILLVLLGGISLGIWKEHQVKRREIKKWSKEHEEMLLLKKGTKSVLKIRDDLQADLDRRKALYKEDWKKALLYPDWRKELFQEAPVRINYEMPDQDKTDSRTEENRGEETVSSSQVDHNLITLSQEGFMLGRYYWEVDVKDTEEWTLGVYELCTQDASLTDPLRKFRVLEKNGDGYRALDFCSQNINSEEPLQLKTRPLKIAIFLDQEDNDLSFYNMTDETHIFSFAQVPFLGSPYPYFTRNSMGLSATAQP
Protein: Col4a6 protein (Q6PFB1)
Organism: Mus musculus (Mouse)
Interaction partners:
Sequence:
MHPGLWLFLVSLCLTKELAESGQKMSYGKPCGSRDCHGVCTCFPEKGARGHPGPIGTQGPAGPEGFTGPTGLSGLKGERGSPGPLGPYGSKGDKGPIGVPGFVGISGIPGHPGQPGPRGPPGPDGCNGTQGAVGFPGPDGYPGILGPPGLPGHKGAKGEPVPFQGSITGIRGDPGLPGLDGIPGPSGSSGSPGDAGPIGPPGLQGPPGLPGLPGPEGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPPGFPGMSGPPGVPEFGSTGEKGEKGILGLPGPRGPMGSEGIQGHPGRQGKKGTSGFPGINGFPGIKGEKGDIGVRGPDSFTDADGAVISGYPGDPGVLGLPGLRGDEGVQGQRGPSGTPGLPSLTGLPGALGPQGFPGLKGDQGNSGRTTFGEAGLPGRVGLPGLPGLPGPSGPPGRTFETGHLSNIEPGFPGLQGEQGPKGHQGLKGVKGDSGFCACEGGAPNIGPHGEPGLPGIQGPIGLQGFKGTKGDPGSRGASGPAGTPGLFGPRGQTGLKGKKGEPTVSRGSKMSGDKGDPGPQGTPGLAGTPGKDGRPGLPGLPGIQGDGGSGFPGERGLPGLPGEKGHDGPIGPPGIGLPGPPGPRGLPGDKGVDGLPGQQGLRGAQGVTLPCIIPGSYGPSGFPGAPGFPGSKGARGLPGIPGKPGTHGSKGGPGSPGLMHLPGLPGFPGVRGEKGLPGFPELPGKDGYPGKAGSPGLPGFKGAAGDIFGAENGASGEQGLQGLPGDKGFPGDSGLPGPKGLNGKPGMLGPKGERGNPGTSGPPGQPGPSGSTDPFGIKGTSGFPGAPGLPGISGHPGKKGQRGDIGQPGSTGKRGLPGIKGLPGPQGSPGFLGSPGLSGVTGLPGIEGQKGEKGSSGPVGFPGLPGLPGLPGADGLKGFSGSFGKVGQPGQTGTSGEKGDRGDPGPVGISSPRPPMLNLWFKGEKGSRGSAGSDGFPGPRGDKGEPGIPGLPGPPGATGQTNTIKGLNGRPGSPGSMGRRGLPGLKGSLGIAGFPGMPGKSGSQGLTGTSGLLGATGIPGLKGDQGQTLGISGSPGPKGQPGELGFKGVKGKDGLVGDRGHPDLCRVTN
Protein: Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (F1SD85)
Organism: Sus scrofa (Pig)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365006}.
Interaction partners:
Sequence:
MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLLSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGSVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDVEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGDEPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDAEMQVDAPSDSSVIAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRVSVFLIRADLNTVFCCVIWNSVVLN
Protein: Wee1-like protein kinase (EC 2.7.10.2) (Q1LYE1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037281}.
Interaction partners:
- Cyclin B1
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase PLK
- Serine/threonine-protein kinase CHK1
- M-phase inducer phosphatase
- Wee1-like protein kinase 2
- Cyclin-A1
- Cyclin A2
- Checkpoint kinase 2.
- cyclin-dependent kinase
Sequence:
MSFGAGRHGKSPNLKPVRQKLQFSTSDGEEDSIEDANNSTGAESGFTELDSPVPLRRSLEKRPEDLGNSSPLSRNRDDDESWDEEGFGSPSRVKPAFYMKSSPSPRKSPPAYDSSPERSYIHDDMEGSSSPIPDCPDTPPHKTFRKLRLFDTPHTPKSLLSRARTMGSTSRRVALFTNVDSTSKACLDGKRNQTPRVNINPFTPDSILVQSSTLQRNNRKRSHWNDSCGEDMDASDAEIEDELIPPSKRITMMENNMMSRYASEFHELEKIGSGQFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHPHVVRYYSAWAEDDHMLIQNEYCNGGTLSDVIAENNRRMHFLSELELKDLLLQVSRGLKYIHSTALVHMDIKPSNIFISRKPAASVEEFEDEEDGPTTNVVYKIGDLGHVTTVTNPQVEEGDSRFLANEVLQEDYSNLKKADIFALALTVVSASGAEPLPTNGDKWHKIRQGILPHIPQVLSQEFLSLLKLMIHPDPTRRPSTSELVRHPVLLTASRMSADQLRVELNAEKFKNALLQKELKKAQMAKAAAEERVLTTDRVLTRSTIQSSSRASRLIGKKMNRSVSLTIY
Protein: Musashi RNA binding protein 2 (cDNA FLJ52888, highly similar to RNA-binding protein Musashi homolog 2) (B4DM51)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH