wanglab/gogpt-training-data huggingface dataset:
Protein: UBX domain-containing protein 2 (Q9N2W5)
Organism: Caenorhabditis elegans
Function: Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. Probably in association with ATPase cdc-48.1 or/and cdc-48.2, regulates the centrosomal levels of kinase air-1 levels during mitotic progression by promoting air-1 removal from centrosomes in prophase. Also, regulates spindle orientation in the one-cell embryo by controlling centration and rotation of the pronuclei-centrosome complex in prophase.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:20977550}. Nucleus {ECO:0000269|PubMed:23649807}. Cytoplasm {ECO:0000269|PubMed:23649807}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23649807}. Note=Colocalizes with cdc-48.1 to the perinuclear region in spermatocytes (PubMed:20977550). Nuclear localization is cdc-48-dependent (PubMed:23649807). During embryonic mitotic metaphase, telophase and to a certain extent prophase, localizes to centrosomes (PubMed:23649807). {ECO:0000269|PubMed:20977550, ECO:0000269|PubMed:23649807}.
Interaction partners:
- Transitional endoplasmic reticulum ATPase homolog 2
- Transitional endoplasmic reticulum ATPase homolog 1
- UBX domain-containing protein 6
- UBX domain-containing protein 1
- ATPase family protein 2 homolog
- UBX domain-containing protein 4
- Ubiquitin fusion degradation protein 3 homolog
- TUG ubiquitin-like domain-containing protein
- Derlin-1
- Ubiquitin fusion degradation protein 1 homolog
Sequence:
MSRNIRTFRDIGNNDDGGPDSDDSGADAAERGAPQEFYAGSGQAVQGPRGAAARGPDSEAHIRRILQAAEVVQPEGGEAPRGRPSGRETISLTLHLWSDGLSIEDGPLMSRQDPRTIEFLESVGKGEIPPSLVQQYPGKEIDFKVNRHHEEYVAPKMKPFGGSGVRLGNVVPTVLGQSSSSATTAGTSSATTDHNPDHTAENEAKQLEDAKKELSTNMNEPTTNIQIRLPNNQRLVGIFNHSHTLEAVRTFICTARPDMIYAPFQMMAAYPPKPFEDESQTLKDANVLNSVVAVKILPTTN
Protein: Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) (Q9CWY8)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Ribonuclease H2 subunit B
- Ribonuclease H2 subunit C
- Ribonuclease H1
- Proliferating cell nuclear antigen
- DNA primase small subunit
- Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
- DNA polymerase epsilon catalytic subunit A
- Thymidylate synthase
- DNA primase large subunit
- DNA replication licensing factor MCM7
Sequence:
MDLSELERDNTGRCRLSSPVPAVCLKEPCVLGVDEAGRGPVLGPMVYAICYCPLSRLADLEALKVADSKTLTENERERLFAKMEEDGDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTAAGLIQYALDQNVNVTQVFVDTVGMPETYQARLQQHFPGIEVTVKAKADSLFPVVSAASIFAKVARDKAVKNWQFVENLQDLDSDYGSGYPNDPKTKAWLRKHVDPVFGFPQFVRFSWSTAQAILEKEAEDVIWEDSEAEEDPERPGKITSYFSQGPQTCRPQAPHRYFQERGLEAASSL
Protein: Protein Wnt (Q99MC1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
Interaction partners:
Sequence:
LRSSRESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKKGSGKDSKGTFDWGGCSDNIDYGIKFARAFVDAKERKGKNAR
Protein: Protein GLUTAMINE DUMPER 7 (Q3E8L0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable subunit of an amino acid transporter involved in the regulation of the amino acid metabolism. Stimulates amino acid export by activating nonselective amino acid facilitators.
Subcellular location: Membrane {ECO:0000269|Ref.6}; Single-pass membrane protein {ECO:0000269|Ref.6}.
Interaction partners:
Sequence:
MSLHRDSMVPVNSRLENMDSPILSKICAWGVMLGLFALSLFAMAYACYHKQTSNSCIEEKQGKKQVLKPLDMEPKIVVIMAGNENPTFFAKPTQINA
Protein: Complement component 6 (Q8BRY4)
Organism: Mus musculus (Mouse)
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MTRHLTLCFILLVMLIDKSEACFCDHYPWTHWSSCSKSCNSGTQSRQRQVVVNDYYWKNLCDKLCIKQETRECNLQTCPINCVLGDYGTWSDCDPCTEKQVKVKSVLRPSQFGGQPCTEPLVTFQPCVPSKLCKIEETNCKNKFLCDSGRCIPSKLECNGENDCGDNSDERNCGRTKPVCTRIYTPIPSVQLMGTGFHFLAGEPRGEVLDNSFTGGICKLVKTSRASNPYRVSANLENVNFEVQTIEDDLKTEFYKNLISF
Protein: DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) (A0A8J8XG14)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MKGDSRHLNEEEGASGYEDCIIVNGNCSDQSSDTKDAPSPPVLEAICTEPVCTPETRGRRSSSRLSKREVSSLLNYTQDVVGDGDGEADDGDGSDILMMPKLTRETKDARTPSESPAVRTRNSNSISSLERQRTSPRITRGRQGRYHVQEYPVEFPATKSRRRRASSSASTPWSSPASIELMEDVTPKSSSTPSVDLSQDGPQEGMDATQVDAESRDGDSTEYQDDKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMPGMRWVQWFGDGKFSEIAADKLVALGLFSQHFNLATFNKLVSYRKAMYHTLEKAMVRAGKTFPSRPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNKQPEVHKSKVRRSGSRNLEARRRENKSRRRTTIDFAASEYSTPPKRLKTNSYGGKDRGEDEESRERMASDVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFQEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKDLGIKVEKYVASEVCAESIAVGTIKHEGQIKYVNDVRKITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYTRPKEGDNRPFFWMFENVVAMKVNDKKDISRFLACNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
Protein: Hypoxanthine-guanine phosphoribosyltransferase, putative (Q38CA1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
- Adenylosuccinate lyase
Sequence:
MHSGHPLKPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL
Protein: Molybdopterin synthase sulfur carrier subunit (Common component for nitrate reductase and xanthine dehydrogenase protein G) (Molybdenum cofactor synthesis protein 2 small subunit) (Molybdenum cofactor synthesis protein 2A) (MOCS2A) (Sulfur carrier protein MOCS2A) (Q9Y8C2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by uba4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03051}.
Interaction partners:
- Adenylyltransferase and sulfurtransferase uba4
- 40S ribosomal protein S6
- Molybdopterin synthase catalytic subunit
- mRNA-nucleus export ATPase
- 40S ribosomal protein S29
- 40S ribosomal protein S15
- Elongation factor 3
- Small ribosomal subunit protein eS19
- 40S ribosomal protein S27
- 40S ribosomal protein S26
Sequence:
MSTFQIHYFASASTYTGRNTESLPAPLPLSSLFDTLEAKYPGIKEKVLSSCSISLGDEYVDLVSDGEKSGNEGLLIQGGDEVAIIPPVSSG
Protein: mitogen-activated protein kinase kinase (EC 2.7.12.2) (A4UU31)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase kinase kinase 7.
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase 8
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase.
- Dual specificity mitogen-activated protein kinase kinase 7
- Beta-arrestin-1
- Arrb2b protein
- Arrestin, beta 2a.
Sequence:
MAAPSSDSGSSCGGGGTAGPAGLSPRLGSIGAQDSNSCWRCQNETGFQINLSGVTQIKRKALKLNFANPPVKPAARLPITSTAPAFQNPHIERLRTHSIESSGKLKISPEQHCDFTAEDLKDLGEIGRGAYGSVNNMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMATSLDKFYKYVYCASDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPRWNSVFDQLTQVVKGEPPQLCSSEDRQFSHKFIQFVNLCLTKDESKRPKYRELLKHPFILMYEERLVDVARYVCRILDQMPASPGSPMYVD
Protein: Zinc finger and SCAN domain containing protein 4C (Q80VJ6)
Organism: Mus musculus (Mouse)
Function: Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187, ECO:0000269|PubMed:20336070}. Chromosome, telomere {ECO:0000269|PubMed:20336070}.
Interaction partners:
- Zinc finger protein 352
- Zinc finger and SCAN domain containing protein 4F
- Zinc finger and SCAN domain containing 4E
- 2 cell stage variable group member 3
Sequence:
MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQSATRPTPDNEQMPVDTTQDRLLATGQENSENECNNSCNATEANVGESCSGNEMDSLLIIQKEQHPEHEEGNVVCQFPHGARRASQGTPSHHVDFPSAPTTADVPMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKSDSLFINKRIYHPEPEVGDIPYGVPQDSTRASQGTSTCLQESLGECFSENDPREVPGLQSRQEQPISDPVLLGKNHEANLPCESHQKRFCRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCVTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD
Protein: TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) (O14545)
Organism: Homo sapiens (Human)
Function: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).
Interaction partners:
- Peptide-N
- TNF receptor-associated factor 6
Sequence:
MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSHPVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSSPCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGASGRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE
Protein: Flavodoxin (P0A3E0)
Organism: Nostoc sp. (strain ATCC 29151 / PCC 7119) (Anabaena sp.)
Function: Low-potential electron donor to a number of redox enzymes.
Interaction partners:
Sequence:
MSKKIGLFYGTQTGKTESVAEIIRDEFGNDVVTLHDVSQAEVTDLNDYQYLIIGCPTWNIGELQSDWEGLYSELDDVDFNGKLVAYFGTGDQIGYADNFQDAIGILEEKISQRGGKTVGYWSTDGYDFNDSKALRNGKFVGLALDEDNQSDLTDDRIKSWVAQLKSEFGL
Protein: Putative high mobility group B protein 11 (Nucleosome/chromatin assembly factor group D 11) (Q9LG02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds preferentially DNA with A/T-rich content.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000255|PROSITE-ProRule:PRU00355}.
Interaction partners:
- Actin-related protein 4
- Histone deacetylase complex subunit SAP18
- Histone H4
- CHD3-type chromatin-remodeling factor PICKLE
- Protein CHROMATIN REMODELING 4
- CHD3-type chromatin-remodeling factor CHR7
- Chromatin structure-remodeling complex protein BSH
- Chaperone DnaJ-domain superfamily protein
- Chromatin structure-remodeling complex protein SYD
- Histone deacetylase 17
Sequence:
MSTDSSQFEVVPANASALDNDVSSHMSMLYQDIVRNPELFWEMLRDFHESSDKKFKIPIVGGKSLDLHRLFNEVTSRGGLEKVIKDRRCKEVIDAFNFKTTITNSAFVLRKSYLKMLFEFEHLYYFQAPLSTFWEKEKALKLLIEKSANRDKDSQELKPGTVITGIIDGKFESGYLISTKVGSEKLKGMLYHISPETKRGKKKAKSSQGDSHKPPKRQRTGYNFFVAEQSVRIKAENAGQKVSSPKNFGNMWTNLSESDRKVYYEKSREDGKRYKMEILQYRSLMESRVAEIVAATDAGTSASAAETADEASQENLAKTDACTSASSAAETEDEVSQ
Protein: Putative PRXamide receptor (Q8ITD1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MLQGVAITIANDSNDDGINQSFMAHVSPSPNQSPSIGVGIGIASSTMANPSESPEMLLLKNDKFLTHVAHLLNITTENLSNLLGSTNGTNASTMAADSPVDESLTLRTAFTVCYALIFVAGVLGNLITCIVISRNNFMHTATNFYLFNLAVSDLILLVSGIPQELYNLWYPDMYPFTDAMCIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVYQNEGYSCTMENDFYAHVFAVSGFIFFGGPMTAICVLYVLIGVKLKRSRLLQSLPRRTFDANRGLNAQGRVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFNDYFRILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNYSALLRQNGSMRLQPASCSVNNNALEPYGSYRVVQFRCRDANHQLSLQDSIRTTTTTTTINSNSMAAGNGVGGGAGGGGRRLRKQELYGPVPGTAVPHRMLQAQVSQLSSLGDANSLLEAEVVDRHYASGRAKRALLATKSGALLVTPPQSGDPSEVSQPATRLKLTRVISRRDEVANASTPPFCGSHSLPDPETCQSASVAGRSSRKFPWRKRRQKTEDPSSEGLTYGSPKSQ
Protein: Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12) (O75746)
Organism: Homo sapiens (Human)
Function: Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:19641205, ECO:0000269|PubMed:24515575, ECO:0000269|PubMed:9722566}; Multi-pass membrane protein {ECO:0000269|PubMed:11566871}.
Interaction partners:
- Mitochondrial import inner membrane translocase subunit Tim13
- Mitochondrial import inner membrane translocase subunit Tim8 A
- Mitochondrial import inner membrane translocase subunit Tim23
- Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim9
- Mitochondrial carrier homolog 1
Sequence:
MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDIMVTIRSHMLTPFVEENLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPAGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPSVAVVQPKAAVAATQ
Protein: Zinc homeostasis factor 1 (O13918)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in zinc homeostasis, where it plays a role in its accumulation in the endoplasmic reticulum/nucleus. Also has a role in the sequestration of cadmium into the endoplasmic reticulum.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11886869}; Multi-pass membrane protein {ECO:0000269|PubMed:11886869}. Nucleus membrane {ECO:0000269|PubMed:11886869}; Multi-pass membrane protein {ECO:0000269|PubMed:11886869}.
Interaction partners:
- Probable zinc transporter zrg17
- Zinc-regulated transporter 1
- Metallothionein zym1
Sequence:
MFDLARQTRIILLLGIDVTFFFIEIITGYAIDSLALIADSFHMLNDIVSLLVALWATRLAHSTSHEPKYTYGWQRAEILGALSNGVFLIALCMFIFMEAIERFIEPPSVSNPTLMFFVGSLGLLSNFVGIFLFHDHGHDHPHTHTAQNYDFPEEDDIESVLPSTIVHRCNTSQQEVSHTHTQVADSATESSPLLSYTGNHNGAGTSKPVNNHGSIEQDAPKQTKKRNLNMHGVFLHVLGDALGNIGVISAALFIKYTDYSWRFLFDPCISILLTFIILFSAIPLCKSAALILLQVAPQSIKLDDVSNLINHLDGVESVHELHIWQLSDVKLIATVHVCVTLPDDKGESYTKLTTDIRNVLQSFGIYDVTIQPEFANHPLLCDQGSSS
Protein: BNIP3, isoform B (Q8IPU8)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004325}.
Interaction partners:
Sequence:
MIGVPQSWIELSTTAAMAGIKSPDRITPLPFNNGEEYLRLLREAQRESNQSSRVVSLASSRRDTPRDSPKSPPNSPQSELCPDDELRNVYINYWTKGGDKQNAGNEDWLKNWNQPPSSWNIEDSSRDAGDEGEKKKTNTGYSIRLKRLGSNSLFSREILYSLLVTNVLSLLLGAGFGLWLSKRGILLTRVVID
Protein: Retrotransposon hot spot (RHS) protein, putative retrotransposon hot spot protein 1 (RHS1), putative (Q8IFI0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MSRANSPAAPQGNNENQQVADNFEGPMRRPRDENVPPPPPPAAAAAAQPPQIRQRTEGGPNWTMDSKVRDVLLDDYAGLRDMTVNDFIQKFVGGTFAVAEAENVRMPIFVKNPRKYIVDAEILEDIQGTNEFKTVKTAIDLSEKVDYLDEKEIYYLSQWEEKGTVEIREFVGPVARGRLDGAVTAAKRAEKRAHQTADGSELKGVYDSIYNATWGYVESGYDEEPLGMKVFNGRPPHMWTKEEVDVSHTPETMNEPLPRHGNLEIAVLTSQMGWPYTSFEKNPNDYDINHEKGVEYVFKSDVYIRREALRVWYKVENVLNRWLMDEVIVDDASNVLIGTPGIGKSFSVGSLLLYKLLHYEASQLQIIIYVVRGKAYVFHKPIGGRAGYVTFYNDYGNAFTVVEQIIGGSRSGEDIKGYVIFDVDKDHPAPTKPPAGCAGIALSSPNVKQFHEWSKQNTASDIYMNCDTLKDLEAIHISRWGKIAPAYKWSPPVAKEKIESEWQEIQARIRIVGPLLRHIGRLSSYNRQEGKVQEAIGKMKDDDMNDYAKYFQNAAMWQTDEVSHKLVGVVRVKEEKLLCEMYRCRPLSSYTGQAILDFLIPWLTDKYAAMSALLSNRAIAAYMFEKSGIEALSHENTLTELARELQGLSFARNQIPQSVLQVLQEPRLIGPSIVVPEDVPIVAGAEIQYMKLYKPQSRSFPVVDAFFFVESPKTFVGLQYTVSGRHPCSTGGLFKMKRYLRSYFQGWDNFSNDMVWEIIYVQRVDSEKITKPQCCERTDRDEGQNNEVEERFWKREVRQFAVSLYKHIIALYVELKTRGENNNGVNNRGGNNA
Protein: MKS transition zone complex subunit 1 (Meckel syndrome type 1 protein) (A3QK09)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000256|ARBA:ARBA00004120}.
Interaction partners:
- Tectonic family member 1
- Meckelin isoform X1
- Centrosomal protein of 290 kDa
- Coiled-coil and C2 domain-containing 2A.
- B9 domain-containing protein 1
- Nephronophthisis 1.
- Transmembrane protein 231
- B9 domain-containing protein 2
- Tectonic family member 2.
- Transmembrane protein 216
Sequence:
MADGWCSDNGESVYRSRDAVKNFRIRVRIQRVTSTAALSEHLHQQVLSQQERGVIELETFSTQTASSTDEEELVVAWQEKFFSQYEVDLYQTESNCQTPLERQYHTDIMAMERSKRRQNQRIFTYTDFDRFSKWEEQAQSLVIPAQPTPTFLAERMANVRHRRQERRPAESNVPKSRLITWEPSEEFVKNSHIINTPVQTMYIMADLGPTGKLGLKENEYVLCTIKADGNGVISIKPDFNNNRGAYRLETEGEKREVWRLYLENASSDIQAEEKDREQRMYRDLYTRHKDYLNSLVGQDFEMPPPGILRLIVNGEIVSAQGYEYDNLYVHFFVDLPNNWSSVSSHCLSGVTQTCRTRSIEKEDVAFFSYPFSFETFFHKEDESDGSLPQWPVLYFKVLSLDFWQRFRTEGYGYLVIPSTSGRHRMTCRTWRAVQRGTVAELRRFFIGGAPELEDISYVRIPGTFKGERLSRFGFRTQTTGSVTFTLNCIQHARAFIDASTLKKRRQTVLDQLGGHSQQGSVYNVLEAFQRAHKRMQEARETLPRDLINTSALLNSESSA
Protein: Clathrin interactor 1 (Epsin-4) (A7Z035)
Organism: Bos taurus (Bovine)
Function: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Membrane {ECO:0000255|PROSITE-ProRule:PRU00243}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network (By similarity). {ECO:0000250}.
Interaction partners:
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Clathrin heavy chain 1
- Phosphatidylinositol binding clathrin assembly protein.
- Clathrin light chain B
- AP-2 complex subunit mu
- Cyclin-G-associated kinase
- Adaptor related protein complex 1 subunit beta 1
- Clathrin light chain A
- AP-1 complex subunit gamma
- AP-2 complex subunit alpha
Sequence:
MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEPKSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKARRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASPDQNASTHTPQSSLKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGNFPSQVTATSGNGDFGDWSAFNQAPSVPVAASGELFGSASQPAVELVSSSQPALGPPPAASNSSDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQPLQNVSTVLQKPNPLYNQNTDMVQKSVSKTLPSTWSDPSVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNMMTQSFGAVNLSSPSNMLPVRPQTNPLMGGPMPMSMPNVMTGTMGMAPLGNSPMMNQSMMGMNMNIGMSTTGMGLTGTMGMGMPNLAMTSGTMQPKQDAFANFANFSK
Protein: 26S proteasome regulatory subunit RPN13 (Proteasome non-ATPase subunit 13) (O13563)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Interaction partners:
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit RPN2
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit RPN9
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome regulatory subunit RPN7
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit RPN12
- 26S proteasome regulatory subunit RPN6
Sequence:
MSMSSTVIKFRAGVCEYNEDSRLCTPIPVQGEIEIKPNEEEELGFWDFEWRPTEKPVGRELDPISLILIPGETMWVPIKSSKSGRIFALVFSSNERYFFWLQEKNSGNLPLNELSAKDKEIYNKMIGVLNNSSESDEEESNDEKQKAQDVDVSMQD
Protein: Leucine-rich repeat-containing protein (Q4GZB6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MGCAGSQQQKPRSNQNIRTKDEGVGPTEPFGAQNGDEFRSCELSTVERPIRLASPGSLSRLEAQQNCRETSHRRRKASKISGKDNFYFSHCSVGGNGRSKSRGTYKLASQDTFADGEMTLTILSNSSSPQLLRIQPSERAQQGDGTWEWWYEQVEKLLVTKDCNSRTRLQDIPNRLTRQYDADKEHVELDLSWCFMERSAPYVLSRLLASPYLVEIRWVTALRLDGNYFTDDGFGSMLEVMSTVNETQLTLPLLRHLYLNNMNLDHHSLHGILFYLFPVDDACYPSVGLTSDSRAIAGRAFGKPPKAYLPFNSAPRIALFPSLTVLSLCDNPGIGNLGLIELLRCFLASHYEHRVLPVLDMSRCGIDEVGARCIREYIEKLPLAVEENRPVVTTQRIVLYGNRHSADRVVAAATDDSPYDTASVVG
Protein: Sprouty4 (Spry4 protein) (Q90XH4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
Sequence:
MESRVPHHIPGVSSSIMVQPLLDSRVPYGRLQHPLTVYPIDQMKALHLENDYIDTPAVISQQPPSHKANPRGQEVLLGAPHHPNLSRCEVPDATTHPWISFSGRPSSISSSSSTSSDQRLLDHAAPTPVVDPYTTGNSHGRTLAAEQPKILSSKNIKTLAALPEEKKKHVLLCEKCGKCRCTECTLPRTLPSCWVCNQECLCSAQNLVDSVTCMCLVKGVFYHCTDEDEEGSCADKPCSCSHSNCCARWSFMAAVSLVLPCLVCYLPATGCAKLSQKCYDGVSRPGCRCKSTQSCKVAEIKACQPEKQAS
Protein: Putative enoyl-CoA reductase (Putative 3-oxo-5-alpha-steroid 4-dehydrogenase) (EC 1.3.1.-) (Q57ZC7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- very-long-chain
- Short-chain dehydrogenase, putative
- Fatty acid desaturase, putative
- Fatty acid elongase 1
- Fatty acid desaturase, putative
- Short-chain dehydrogenase, putative
- Vacuolar transporter chaperone complex subunit 1
Sequence:
MKVTVISGSSSEVVELPSNAGLTDLKKVYKPRVDIHRKSFKILRSGGDKNDKSAYITLDAKRALTEQGVKDGSEVVYKDLGPQVGYRTVFVVEYAGPLAIMLAYAARPSFIYGSSIVKEYCYTQKLYIALFCAHFIKRELETFFVHKFSHPTMPRRNIIKNCVYYWTFALGIGYALCSPYYTEPASPTLVNASAVAMVIFELLNFAVHVQLSGMRKGDGDATRPVPKGILFSLVSCPNYLFEILSWVAFSLGTSMLTSWGFTFAGLVQMAEWAVKKHKNYIKTDPSVRNKKAMLPFLL