wanglab/gogpt-training-data huggingface dataset:
Protein: Acidic leucine-rich nuclear phosphoprotein 32 family member A (Leucine-rich acidic nuclear protein) (LANP) (P49911)
Organism: Rattus norvegicus (Rat)
Function: Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A.
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Translocates to the cytoplasm during the process of neuritogenesis. Shuttles between nucleus and cytoplasm (By similarity). {ECO:0000250}.
Interaction partners:
- Exportin-1
- Protein SET
- ELAV-like protein 1
- TNF superfamily member 13
- Ataxin-1
Sequence:
MEMDKRIYLELRNRTPSDVKELVLDNCRSIEGKIEGLTDEFEELEFLSTINVGLTSISNLPKLNKLKKLELSENRISGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNAYRENVFKLLPQVMYLDGYDRDNKEAPDSDVEGYVEDDDEEDEDEEEYDEYAQLVEDEEEEDEEEEGEEEDVSGEEEEDEEGYNDGEVDDEEDEEDAAEEEGSQKRKREPDDEGQEDD
Protein: Syntaxin UFE1 (P41834)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Syntaxin required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Interaction partners:
- Protein transport protein SEC22
- Protein transport protein USE1
- Protein transport protein SEC20
- Protein transport protein DSL1
- Protein transport protein TIP20
- Protein transport protein SEC39
- Integral membrane protein SED5
- Protein SLY1
- Synaptobrevin homolog YKT6
- Protein transport protein BET1
Sequence:
MMSDLTPIFRKYVAVIDDARNEQNGIDDHVERKQEDFGNSNETCEMFRDSFIKECARLLKFLVELNKVIKQIEKNYLDDFNMSDAEKDEFDMECRLQIQQYFKKFEFLENYEMERHNLSLKRFQSKSHRWSKILSNKNDNTKHVIHPQDIENGVYEFRLGVLRCLNLWIKYVSSKFTTIQQERLILENKMNFNSTPMPTLSNNADDFSADAIDISVSQSAPVETVQDEVKHYEETISKLTQEQLQVLETEHSELLNQKNEQLKKVETINKTILDIVNIQNELSNHLTVQSQNINLMLNNQDDIELNIKKGNKELRKAKRAAGRTAKMTTYGAIIMGVFILFLDYVG
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A8I5ZLY4)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MLFCLLVAMAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVRMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPVSEKAKGLILRFCCEWEHRIGAPGVEEIKSNPFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVTTSNHPETDYKSKDWVFINYTYKRFEGLTARGAIPSYMKAAK
Protein: Photosystem II reaction center protein K (PSII-K) (P0C410)
Organism: Oryza sativa subsp. japonica (Rice)
Function: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00441}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00441}.
Interaction partners:
- Cytochrome b559 subunit alpha
- Photosystem II reaction center protein H
- Photosystem II CP47 reaction center protein
- Photosystem II CP43 reaction center protein
- Photosystem II reaction center protein L
- Photosystem II D2 protein
- Photosystem II protein D1
- Cytochrome b559 subunit beta
- Photosystem II reaction center protein J
- Photosystem II reaction center protein I
Sequence:
MPNILSLTCICFNSVIYPTSFFFAKLPEAYAIFNPIVDFMPVIPVLFFLLAFVWQAAVSFR
Protein: Small ribosomal subunit protein uS3m (Ribosomal protein S3, mitochondrial) (Q7JAJ0)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Interaction partners:
Sequence:
MARKGNPISVRLDLNRSSDPSRFSDYYYGKSLYQDVNLRSYFSSIRPPTILTFGFRLGRCIILHFPKRTFIHFFLPRRPLRLKRRDKSRPGKDKGRWWAFGKVGPIGCLHSSEGTEEERNEVRGRGAGKRVESIDREKQNEIRIWPKKMQRYGYHDRSPSRKKNFSKSLRVSGAFKHPKYAGVVNDIAFLIENDGPTSHLLKRTLPAVRPSLNYSVMQYFFNTKNKMHFDPVVVLNHFVAPGVAEPSTMGGAKGGSLDKRIRSRIAFFVESSTSEKKCLARAKKRLIHFIRQANDLRFAGTTKTTISLFPFFGATFFFPRDGVGVYNNPFFEYAREQLLGQLRIKCRNLMGKDKVMELIEKFIYLGRIGKLIKGIEMMIEIILRKRIIPYGYNSYLNEVQKMRSFLSNRTNTNTLIESVKIKSVYQSASLIAQDISFQLGNNPISFRSIFSQIVKDIPLIMPKGVEGIRICCSGRLGGAEIARTECGKYGKTSCNVFNQKIDYALAEVSTRNGISGVKVRISYSQNKKGRAISETYEI
Protein: Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) (O88794)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Interaction partners:
- Pyridoxal kinase
- Chronophin
- Aldehyde oxidase 1
- Aldehyde oxidase 3
- Aldehyde oxidase 4
- Aldehyde oxidase 2
- Pyridoxal phosphate phosphatase PHOSPHO2
- Phos_pyr_kin domain-containing protein.
- YjeF N-terminal domain-containing protein 3
- Pyridoxal phosphate homeostasis protein
Sequence:
MTCGLLSVTVTFRRPAKWPGYFRHLCCRGAVMDLGPMRKSYRGDREAFEEAHLTSLDPMKQFASWFEEAVQCPDIGEANAMCLATCTRDGKPSARMLLLKGFGKDGFRFFTNYESRKGKELDSNPFASLVFYWEPLNRQVRVEGPVKKLPEKEAENYFHSRPKSSQIGAVVSRQSSVIPDREYLRKKNEELGQLYREQEVPKPEYWGGYILYPQVMEFWQGQTNRLHDRIVFRRGLATGDSPLGPMTHHGEEDWVYERLAP
Protein: Small ribosomal subunit protein uS3c (30S ribosomal protein S3, chloroplastic) (P0C484)
Organism: Oryza sativa subsp. indica (Rice)
Subcellular location: Plastid, chloroplast.
Interaction partners:
- Large ribosomal subunit protein uL2 C-terminal domain-containing protein
- 60S ribosomal protein L21
- 60S ribosomal protein L29
- 60S acidic ribosomal protein P1
- Large ribosomal subunit protein uL16c
- Large ribosomal subunit protein uL3m
- 60S ribosomal protein L17
- 60S ribosomal protein L17
- Small ribosomal subunit protein uS9
- 60S ribosomal protein L6
Sequence:
MGQKINPLGFRLGTTQNHHSFWFAQPKNYSEGLQEDKKIRNCIKNYIQKNRKKGSNRKIEADSSFEVITHNKKMDSGSSSEVITHIEIQKEIDTIHVIIHIGFPNLLKKKGAIEELEKDLQKEVNSVNQRLNIGIEKVKEPYRQPNILAEYIAFQLKNRVSFRKAMKKAIELTKKTDIKGVKVKIAGRLAGKEIARAECIKKGRLPLQTIRAKIDYCCYPIRTIYGVLGVKIWIFVDEE
Protein: Synaptotagmin 2 (K8FE10)
Organism: Caenorhabditis elegans
Function: Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds.
Subcellular location: Cytoplasmic vesicle {ECO:0000269|PubMed:23583549}. Note=Co-localizes with nlp-40 in cytoplasmic vesicles. {ECO:0000269|PubMed:23583549}.
Interaction partners:
- Syntaxin-1A homolog
- MARVEL domain-containing protein
- Ras-related protein Rab-3
- ATP-grasp domain-containing protein
- Acetylcholine regulator unc-18
- Endophilin-A homolog
- Putative stoned B-like protein
- Synaptobrevin-1
- Variant SH3 domain protein
- FCH domain only protein 2
Sequence:
MWATGAIVCSPVFRILSTCCPIRRGVPTSNGYHPRPKHVDIGNGAVPILSSKPITVQPTNSDYYEPVNNGTLPLSSSGALIKQYGNIHFRVEYDFEQSKLSVTIVSASDLPAMDRNGMSDPYVKVYVLPERKQKFETRIIRNTLNPTYNETFQFSIPFNELHSKTLMLVVYDYDRLSKDDKMGQLSVPLESIDFGITTDIERPLQKPEKDDEKECRLGDICFSTRYRPATGTVTLTIMEARNLKKMDVGGSSDPYVKIYLHHGRKLLSKKKTSRKYKTLNPYYNESFQFKIEPHMIEKVHLIVSVWDYDKMSKNDFIGEVTLGSKHLNLPQITHACSEQWAEMMTSRRPVVQWHTLQERMEKEKKKDDD
Protein: Plasmanylethanolamine desaturase 1 (EC 1.14.19.77) (Transmembrane protein 189) (A5PLL7)
Organism: Homo sapiens (Human)
Function: Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11076860, ECO:0000269|PubMed:31604315}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Ethanolaminephosphotransferase 1
- Choline/ethanolaminephosphotransferase 1
- Lysophospholipid acyltransferase LPCAT4
- HCG2044781
- Phospholipase D1
- 5'-3' exonuclease PLD4
- 5'-3' exonuclease PLD3
- Phospholipase D2
- Ubiquitin conjugating enzyme E2 V1
- Polyubiquitin-C
Sequence:
MAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDTPLVILGVVAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEKIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK
Protein: Metabotropic GABA-B receptor subtype 3, isoform F (X2J488)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Interaction partners:
Sequence:
MRIIQPVQGTRYGPWPAVGLRLVLALAWATSAAAAMESSAELQALGYEAIRPGAASISTSSPSSSPPGESASTVTAGGTPIPPRSDWKYKRTKVKRRQQRLNSHSNLPGSTNASHAHHLLNLPPRQRYLKVNQVFESERRMSPAEMQRNHGKIVLLGLFELSTSRGPRPDGLSELGAATMAVEHINRKRLLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRSAWINVSLADHIA
Protein: Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) (Q9Y6R9)
Organism: Homo sapiens (Human)
Function: Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Has been proposed to play a role in CEP170 recruitment to centrosomes. However, this function could not be confirmed. Plays a non-essential role in ciliogenesis.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:32375023}. Note=Localization at the centriolar satellite is dependent on intact microtubule network (PubMed:30354798). Localizes at the centriole subdistal appendages and proximal ends (PubMed:31789463). Localized to centrosomal/satellite-like structures with the onset of centrosome separation in early G2 (PubMed:30354798). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463}.
Interaction partners:
- Centrosomal protein of 170 kDa
- Ninein
- Centrosomal protein of 128 kDa
- Kinesin-like protein KIF2A
- Outer dense fiber protein 2
- Dynactin subunit 1
- Coiled-coil domain-containing protein 120
- Centriolin
- Coiled-coil domain-containing protein 68
Sequence:
MDQPAGLQVDYVFRGVEHAVRVMVSGQVLELEVEDRMTADQWRGEFDAGFIEDLTHKTGNFKQFNIFCHMLESALTQSSESVTLDLLTYTDLESLRNRKMGGRPGSLAPRSAQLNSKRYLILIYSVEFDRIHYPLPLPYQGKPDPVVLQGIIRSLKEELGRLQGLDGQNTRDTRENEIWHLREQVSRLASEKRELEAQLGRSREEALAGRAARQEAEALRGLVRGLELELRQERGLGHRVAGRRGQDCRRLAKELEEAKASERSLRARLKTLTSELALYKRGRRTPPVQPPPTREDRASSSRERSASRGRGAARSSSRESGRGSRGRGRPARPSPSPTGGRALRFDPTAFVKAKERKQREIQMKQQQRNRLGSGGSGDGPSVSWSRQTQPPAALTGRGDAPNRSRNRSSSVDSFRSRCSSASSCSDLEDFSESLSRGGHRRRGKPPSPTPWSGSNMKSPPVERSHHQKSLANSGGWVPIKEYSSEHQAADMAEIDARLKALQEYMNRLDMRS
Protein: Dystrobrevin binding protein 1 (D6RID1)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00037838}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037838}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037838}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Endosome membrane {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004125}. Melanosome membrane {ECO:0000256|ARBA:ARBA00037798}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037798}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037798}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}.
Interaction partners:
Sequence:
MLETLRERLLSVQQDFTSGYEDTWAALHRRAKDCASAGELVDSEVVMLSAHWEKKKTSLVELQEQLQQLPALIADLESMTANLTHLEASFEEVENNLLHLEDLCGQCELERCKHMQSQQLENYKKNKRKELETFKAELDAEHAQKVLEMEHTQQMKLKERQKFFEEAFQQDMEQYLSTGYLQIAERREPIGSMSSMEVNVDMLEQMDLMDISDQEALDVFLNSGGEENTV
Protein: Insulin [Cleaved into: Insulin B chain; Insulin A chain] (P01317)
Organism: Bos taurus (Bovine)
Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subcellular location: Secreted.
Interaction partners:
- Insulin-like growth factor 1 receptor
- Tyrosine-protein kinase receptor
- Insulin-like growth factor 1
- Albumin
- Insulin receptor substrate 1
- Insulin-degrading enzyme
- Insulin receptor substrate 2
- Receptor protein-tyrosine kinase
- Tyrosine-protein kinase receptor
- Platelet-derived growth factor receptor alpha
Sequence:
MALWTRLRPLLALLALWPPPPARAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEGPQVGALELAGGPGAGGLEGPPQKRGIVEQCCASVCSLYQLENYCN
Protein: Acidic phospholipase A2 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (P86907)
Organism: Bothrops ammodytoides (Yararanata) (Patagonian lancehead)
Function: Snake venom phospholipase A2 (PLA2) that displays low systemic toxicity and causes severe symptoms only at very high concentrations (15 mg/kg). Has neither coagulant nor anticoagulant activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Subcellular location: Secreted {ECO:0000269|PubMed:22975267}.
Interaction partners:
Sequence:
HLMQFETLIKKIAGRSGVWFYGFYGCYCGSGGRGKPKDATDRCCFVHDCCYGKVTGCDPKMDFYTYSEENGVVVCGGDDPCKKQICECDRVAATCFRDNKTYDNNKYWFYPAKNCQEESEPC
Protein: U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase (EC 2.1.1.-) (F4IGH3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
- FKBP12-interacting protein of 37 kDa
- UDP-rhamnose/UDP-galactose transporter 5
- UDP-rhamnose/UDP-galactose transporter 6
- UDP-rhamnose/UDP-galactose transporter 3
- WD repeat-containing protein LWD2
- E3 ubiquitin-protein ligase HAKAI homolog
- RNA demethylase ALKBH10B
- UDP-rhamnose/UDP-galactose transporter 4
- Casein kinase II subunit beta-3
- Poly
Sequence:
MRSGKKRARSEPGSTKQPRSKYSDNPPDFASLASLYPSFKPFVFFSGSRARIDWTDYNATRELTRVLLLHDHGVNWWIPDGQLCPTVPNRSNYIHWINDLLSSGIIQSLGGDGSKVKGFDIGTGANCIYPLLGASLFGWSFVGSDFTVVALEWAEKNVQSNPHFSDLIEIRDSKVPPQCSSVPEVENTEREKTIQEEAEISATVKSDYHDNKSFIEPAVLLGVVKENETFDFCMSNPPFFETFEEAGLNPKTSCGGTPEEMVCNGGEQAFVSRIIKDSAVLRQRFRWYTSMLGKKANLKLLISKLWEVGVTIVKTTEFVQGQTSRWGLAWSFMPIARKIIAPPVVKKSVLSFMLECIKRQYSAVDVLQSVEEFFKSCGASCKLNSSTFSVDIVASNDQCNTISKNDIADVDSVRSHGYEKQSLDGSSLQVPEYNLSFRILVFQQMPGTLLIKGSLQQKDSPLSGLFSRVFGSLEESLKSKFCRLTLRGKIHRAKLDYPKVVKERERERVLHFT
Protein: Protein ERGIC-53-like (ERGIC53-like protein) (Lectin mannose-binding 1-like) (LMAN1-like protein) (Q9HAT1)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Interaction partners:
- Multiple coagulation factor deficiency protein 2
Sequence:
MPAVSGPGPLFCLLLLLLDPHSPETGCPPLRRFEYKLSFKGPRLALPGAGIPFWSHHGDAILGLEEVRLTPSMRNRSGAVWSRASVPFSAWEVEVQMRVTGLGRRGAQGMAVWYTRGRGHVGSVLGGLASWDGIGIFFDSPAEDTQDSPAIRVLASDGHIPSEQPGDGASQGLGSCHWDFRNRPHPFRARITYWGQRLRMSLNSGLTPSDPGEFCVDVGPLLLVPGGFFGVSAATGTLADDHDVLSFLTFSLSEPSPEVPPQPFLEMQQLRLARQLEGLWARLGLGTREDVTPKSDSEAQGEGERLFDLEETLGRHRRILQALRGLSKQLAQAERQWKKQLGPPGQARPDGGWALDASCQIPSTPGRGGHLSMSLNKDSAKVGALLHGQWTLLQALQEMRDAAVRMAAEAQVSYLPVGIEHHFLELDHILGLLQEELRGPAKAAAKAPRPPGQPPRASSCLQPGIFLFYLLIQTVGFFGYVHFRQELNKSLQECLSTGSLPLGPAPHTPRALGILRRQPLPASMPA
Protein: Angiopoietin-1 (ANG-1) (Q15389)
Organism: Homo sapiens (Human)
Function: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
Subcellular location: Secreted {ECO:0000269|PubMed:8980223}.
Interaction partners:
- Angiopoietin-1 receptor
- Tyrosine-protein kinase receptor Tie-1
- High affinity nerve growth factor receptor
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 1
- Angiopoietin-4
- Angiopoietin-2
- Vascular endothelial growth factor receptor 3
- Platelet-derived growth factor receptor beta
- Epidermal growth factor receptor
Sequence:
MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYTFILPEHDGNCRESTTDQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTYIIQELEKQLNRATTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF
Protein: methylmalonate-semialdehyde dehydrogenase (CoA acylating) (EC 1.2.1.27) (G3V4Z4)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
Protein: Eyes absent homolog (EC 3.1.3.48) (B1APR7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MIIPHKCILQTSSTNASLISTSSTIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAESTTLAATTYQSEKPSVMAPAPAAQRLSSDPSTSPSLSQTTPSKDTDDQSRKNMTSKNRGKRKADATSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
Protein: Transcription factor (Q24107)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MENATTTTAKHYKTAGKQYKTNKVNNTRRATAAAAAAATTTVTTAATPTKKRTYRETATATTVTQRSTNKANIAAAIALAAATEATASASASATATATDATLTASKAAATAAATTDAASGNSNSSSKPSTSTRDKLGEVPLPTVDSNHIISNNNNNNNNNNTSNNNNNNHHSDNSISENNYEFKSRDKASLSDSKMTLQQMAAVSSNQEPVAPNVANTMSNSSIINSQQTTVNATPATDEAPLGDRSNISRYLHKKFKRLASTTEVDSWSATNGGGALQASGDAVRTTSLSSNSSLSPPPTTPLANGHHLMTQQQSHQQVQQQQQQQTPPPSVAIHEFSANFVNSNHVNAIGHEESIISNSGYKAAGRTRTPLANSNSNTNSTSNSNSNHAANATLSPASFAQHQQLTQPTTVSPGIPGGAAAPNPACEKSGRYVCQYCNLICAKPSVLEKHIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAARARGLEVPADADDGLSDQDAELSNSSSELPSRAGSPYEEPINSPTPSPSTLSAAKSAYIQQPPLPTYMQQLPLGSPAAGTLPPTTADNHHSATAQHRQSIDYKPYKPKFHNASMYSCSSKELQQQQQQLQIQQQQQQHQLAQQKLSIQLPLVQQPSLAHPTLSPSTQMKMKHHINSHQIQLQLQQQQSLLAQQSLLAAMPPGGVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHLAQQQQQQQQQHPPLVKATPPMQQPPSLPPQQLVRANSQISSVATAPATPTPAANLSTFASSSGGKQVNVAKVQEHISKLISQNEAIVENKEILLQKKYPKQLSRSRSFNNANSNNASQHGSNASALHANNSHNNTNAQMPERETKVNLAQAIFQKQQHQLQQQQQQQITQQQQQQLEQQNYYTYIQQQQECQQQQLEPPNGVVKRNAYKPGVVMTTPVKQQQQLPPPPSPLPMQTMQYRQDPATPVTKIEQPTTAVPVMPLNLSAKPKPTLVTVPVSSLSTSSLAPTPTTSTNPTSSSKTAPPPAQVNNSIIKNLLLNARGLAVPIGEGDDAVYSCPICASEFRSADDLKLHNSTYCQDASSSAPMSPASSPFRSNSISLSLPELKSHMANSKNPLSLAKLAWSQLKTKRSSLVLSRLSAAQTPARTSTVTAPTVTASAPAPAVATVTAPSSAPAPQIEALRFVDAPLPSPGPLLGKTPLVDYAQQSTPRKAQDSVVITKMHEDRQFVIEAQPAKRIKTSDLVVASSSQQPTSFNFSFNNQNSSNSVPELQSSKEERLRRFTSSGGSMIPISECPDLDNSPKMIRTPLLSGGSFQDVSVKVNNETGSSSKERKLMALVSGSGLLGVSSGPQHFQFPPINSITAFNPLTLPPMSGGDKTTPVTPIPHVPGMPGPGSLTPQMPLLPPPPQQLQLPIPSSRGRSPNRKQPSPLLLGGGSGELKALSPFGGVQNVPSEFSRQPPTPAQRQALQWNSKETPKKAPFNFLRMADNVKTTEPEVRHFNLENVISGKQQELPLTPLHVDTPNGNAPEETSPVASASASAKSKFLRPTSLPLKPGTFTPKRHHGITPTANTLPLISPETPRPSKSCVQLYLNGHAYTYLGLKCSTKMFYCTVNCPQPSYVAGMHKLSMYSVWQVCEENQPHPLGFKLKQVMALYDSRQRMLGNGSSTAMAGSGKLSYNLVASQQIVSSPSTSSTSSAFYQGPLKTPPTVTIAALSEANVAAKANEEAQAKKLETSPSGQPLVGGYESHEDYTYIRGRGRGRYVCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGPMPPDSEFLDVDMDFDQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQKEHEAARGLLSLSMTPPIPQSVSPYPQLQDTPLPAASPANSIGSSGSQPKRLVCSFTSPKPPFDYQKQEQYYSNPEESKPKRSVANEESAPMDLTKPRGSILLISPSPVSVPAHDLPKSQAQQMHDVIFGTSGNESGFMKTLISVSDKVRISAEMEEQAKHEAEGEDVQLQTYIKEHALHQAKIKQSQFSRSYLINTLYTAASPVMSSSSTLFTANSRPVMSVNEVPSIEVHEVKTPEAIESPRSAPEQAPVILAQIAQEENEEPNIAEPHNANLPAAVQQPDVNEFTGVLGNPTAPPTSSVTATSVSTTTAAPVAPSSTANSTQPAQRTVIVGEDGFKSSTPTSKIGDLQHVSYGRGVPPAPIAGDARPTCTMCSKTFQRQHQLTLHMNIHYMERKFKCEPCSISFRTQGHLQKHERSEAHKNKVMMTSTFGVPTTSNPRPFECTDCKIAFRIHGHLAKHLRSKTHVQKLECLQKLPFGTYAEIERAGISLTEIDTSDCENSLISLKLLAQKLQEKDPGKLSSYTTPSGMMQLAQDAAGPVSQDSASEDGFSAAIASAIASLDNDSAGNTPKRASSMSEDETVANGLNHSLKRRLPGSFSSTGEESDNPPESSGEKRARSGQELPLPVAVPVAASAAASN
Protein: Chromatin modification-related protein EAF3 (Q59K07)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00972}.
Interaction partners:
- Chromatin modification-related protein EAF7
- Enhancer of polycomb-like protein 1
- Protein AF-9 homolog
- PHD-type domain-containing protein
- Chromatin modification-related protein EAF6
- Ume1p
- Chromatin modification-related protein YNG2
- SWR1-complex protein 4
- Histone acetyltransferase
- Chromatin modification-related protein EAF1
Sequence:
MVEYKPNQTVYAYHGPLIYEAKILKLKNGKDSFIINQDFQHEPLEEKPNSSGNHHHHHHSQHIAKFDPKKWQDQTCYYLHYQGWNSKWDEWVGIDRIMEYNEENKFKKLELDQLTKKKKAINNNEIIVNATTKNHTNNKNKKESNKRKSSSATTTSGVTAGTNNNKKQKSASTSTTNNTSGNSGTTSNKSKQILSRLNLNFPPELKHILVNDWEYITKDRKLVSLPSQYPINQILQDYKTYRTKQLTSNSDQLSILIEILTGLEIYFNKSLSLILLYKYEHLQYLNFLKQNIINPQQDILQSNIYGVEHLLRLIISFPGLLSTTTMDGISLSVLISELESLCRFIGDRLQLYQNNYEFTSPQYDSLARS