wanglab/gogpt-training-data huggingface dataset:
Protein: Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1) (Complete S-transactivated protein 1) (Q9BRF8)
Organism: Homo sapiens (Human)
Function: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23799035}.
Interaction partners:
- Cystatin-SN
- Cystatin-SA
- Cystatin-C
- NAD-capped RNA hydrolase NUDT12
Sequence:
MSAAEAGGVFHRARGRTLAAFPAEKESEWKGPFYFILGADPQFGLIKAWSTGDCDNGGDEWEQEIRLTEQAVQAINKLNPKPKFFVLCGDLIHAMPGKPWRTEQTEDLKRVLRAVDRAIPLVLVSGNHDIGNTPTAETVEEFCRTWGDDYFSFWVGGVLFLVLNSQFYENPSKCPSLKQAQDQWLDEQLSIARQRHCQHAIVFQHIPLFLESIDEDDDYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGRDPHGLRVVVVTAEKIVHRYYSLDELSEKGIEDDLMDLIKKK
Protein: Mitochondrial Rho GTPase 1 (EC 3.6.5.-) (GTPase EF-hand protein of mitochondria 1) (P39722)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (Probable).
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:15479738, ECO:0000269|PubMed:16407407, ECO:0000269|PubMed:16823961}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15479738, ECO:0000269|PubMed:16407407, ECO:0000269|PubMed:16823961}.
Interaction partners:
- Mitochondrial distribution and morphology protein 34
- Mitochondrial distribution and morphology protein 12
- Mitochondrial distribution and morphology protein 10
- Maintenance of mitochondrial morphology protein 1
- Mitochondrial import receptor subunit TOM7
- Mitochondrial import receptor subunit TOM40
- Mitochondrial import receptor subunit TOM70
- Mitochondrial import receptor subunit TOM22
- Myosin-2
- Mitochondrial import receptor subunit TOM20
Sequence:
MTKETIRVVICGDEGVGKSSLIVSLTKAEFIPTIQDVLPPISIPRDFSSSPTYSPKNTVLIDTSDSDLIALDHELKSADVIWLVYCDHESYDHVSLFWLPHFRSLGLNIPVILCKNKCDSISNVNANAMVVSENSDDDIDTKVEDEEFIPILMEFKEIDTCIKTSAKTQFDLNQAFYLCQRAITHPISPLFDAMVGELKPLAVMALKRIFLLSDLNQDSYLDDNEILGLQKKCFNKSIDVNELNFIKDLLLDISKHDQEYINRKLYVPGKGITKDGFLVLNKIYAERGRHETTWAILRTFHYTDSLCINDKILHPRLVVPDTSSVELSPKGYRFLVDIFLKFDIDNDGGLNNQELHRLFKCTPGLPKLWTSTNFPFSTVVNNKGCITLQGWLAQWSMTTFLNYSTTTAYLVYFGFQEDARLALQVTKPRKMRRRSGKLYRSNINDRKVFNCFVIGKPCCGKSSLLEAFLGRSFSEEYSPTIKPRIAVNSLELKGGKQYYLILQELGEQEYAILENKDKLKECDVICLTYDSSDPESFSYLVSLLDKFTHLQDLPLVFVASKADLDKQQQRCQIQPDELADELFVNHPLHISSRWLSSLNELFIKITEAALDPGKNTPGLPEETAAKDVDYRQTALIFGSTVGFVALCSFTLMKLFKSSKFSK
Protein: Proteasome 20S subunit beta 10 (A0A8I6AKB6)
Organism: Rattus norvegicus (Rat)
Interaction partners:
Sequence:
MSKRQSGERLVSNPLGLDPSVYLAWGHLEEDIREREAGIISSPALCSGCGVPAITPALSYNQRIVNGENAVPGSWPWQVSLQDNTGFHFCGGSLIAPNWVVTAAHCKVTPGRHFVILGEYDRSSNAEPIQVLSISKAITHPSWNPNTMNNDLTLLKLASPARYTAQVSPVCLASSNEALPAGLTCVTTGWGRISGVGNVTPARLQQVVLPLVTVNQCRQYWGSRITDSMICAGGAGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTENCNVQAPAMYTRVSKFNTWINQVMAYN
Protein: Multisite-specific tRNA:(cytosine-C(5))-methyltransferase trm4b (EC 2.1.1.-) (tRNA (cytosine-5-)-methyltransferase trm4b) (O13935)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: tRNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in tRNAs at position 49 and 50. Trm4a and trm4b methylate different sets of tRNAs. Also methylates cytosine to m5C at positions (60, 61 and 62) in tRNA(Asp).
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- tRNA
- Ribosome production factor 2 homolog
- 60S ribosome subunit biogenesis protein nip7
- tRNA
- Ribosome assembly factor mrt4
- 25S rRNA
- Pumilio homology domain family member 6
- Uncharacterized NOC2 family protein C1142.04
- tRNA
- Probable rRNA-processing protein ebp2
Sequence:
MGKRNKKVTQGKRAYNDKSEIVLENKQFEGYYKKQNLFRGKPNDEFDSFMEYMRKPLPTTFRICGYRHHAFELKNHFEKYYVPSLKNVVHEGQTIPPPTVLPWYPDGLAYIVDAQKDVIRKSPPLKRLQRFLVSENEAGNINRQEAVSMLPPLFLDVEPHHVILDMCAAPGSKTAQLIEAVYKKANIKDAAHDSKNLKSVEGLVIANDADPKRAQMLVHQINRLNSPNILVVNHDASTMPNIYVKGSSPSDGLNVIEEKKILKFDRILADVPCSGDGTFRKNLSLWREWSANSAFSLHPLQLRILIRGLQLLKVGGCLVYSTCSINPIENEAVVTAALKATGGAVSLVDVSKKLPLLKRDPGLLSWKVLDDSLNEFQSPAENTNDKIELTESMWPLPEEEMSKLHIERCARLYPHMQNTGGFFVAVLQKTDPINSRSFDPKKYTASMEILPPENKRQRTEKGVDEASNSTLTKSGNSYFDEEPFVYINPDDTSIKTIVDFYGIDPSFPRDQFFVRNQSGIPVRSIYFACSLFKEIIEANTNRVKFVHGGVRFFVKQEISQLLKDFSLKANKDICNFRIHSNGVNIISPFLNEKHFYDAGLKDLKILVKNEYPHVEQFSESGMLKKEFEKMPLGCNILRVDAQTKDGALMDMLILQPIWRSPTSCNLMLARKEKQNLSLELFGMDV
Protein: Exportin-1 (Chromosome region maintenance protein 1) (Karyopherin-124) (P30822)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Receptor for the leucine-rich nuclear export signal (NES).
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:14562095}. Note=Localized in the nucleus and at its periphery.
Interaction partners:
- GTP-binding nuclear protein GSP1/CNR1
- Ran-specific GTPase-activating protein 1
- Ran-specific GTPase-activating protein 2
- Nucleoporin NUP159
- 60S ribosomal export protein NMD3
- U3 small nucleolar RNA-associated protein 8
- GTP-binding nuclear protein GSP2/CNR2
- Nucleoporin NUP42
- mRNA export factor MEX67
- Protein LTV1
Sequence:
MEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQKADQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMIISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSSVNVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDTRAITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKATYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQLSKIEERELFKTTLDYWHNLVADLFYEVQRLPATEMSPLIQLSVGSQAISTGSGALNPEYMKRFPLKKHIYEEICSQLRLVIIENMVRPEEVLVVENDEGEIVREFVKESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLDLTVKKRGKDNKAVVASDIMYVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIIISEERSVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANIIKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINKDFTEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQALLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYLANMLSNAFPHLTSEQIASFLSALTKQYKDLVVFKGTLRDFLVQIKEVGGDPTDYLFAEDKENALMEQNRLEREKAAKIGGLLKPSELDD
Protein: Large ribosomal subunit protein bL12m (39S ribosomal protein L12, mitochondrial) (L12mt) (MRP-L12) [Cleaved into: Large ribosomal subunit protein bL12m, long mature form; Large ribosomal subunit protein bL12m, short mature form] (Q9DB15)
Organism: Mus musculus (Mouse)
Function: As a component of the mitochondrial large ribosomal subunit, it plays a role in mitochondrial translation. Associates with mitochondrial RNA polymerase to activate transcription.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P52815}.
Interaction partners:
- Large ribosomal subunit protein bL21m
- Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein bL17m
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein bL9m
- Large ribosomal subunit protein bL20m
- Small ribosomal subunit protein uS3
- Large ribosomal subunit protein uL14
Sequence:
MLPVAASRCLWGPRLGLRGAALRLARQQMPSVCAARQLRSSSHRRSEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLMPMGGMVPGPVSAAAPASEAAEEEDVPKQKERTHFTVRLTEAKPVDKVKLIKEIKNYVQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE
Protein: Uncharacterized oxidoreductase pbr1 (EC 1.-.-.-) (O13822)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P53878}; Single-pass membrane protein {ECO:0000255}.
Interaction partners:
- 1,3-beta-glucan synthase component bgs3
- 1,3-beta-glucan synthase component bgs4
Sequence:
MPIPIIAHIAQFKYEHLITHWAQYTKAAIAVSTIAAFKFWTSGRTTTWERKMNGMVVMVTGGSSGIGQVVVEKLASLGAQVVILLRTEPDQFTVDYIMDLRKRTKNQLIYTEVCDLSSMLSVRKFATKWIDCTPIRRLDMIVLCSGVLLPPFMDRQTTEEGVELQWATNFLGPYQLLRILRPVIYGQPGHREVRIVAATCSSYILGNIDFNDLDLSNHPYPRKSPWKVVGNAKLALMTYLYDFQKKAEAHERPDKMPCNLHTIMANPGVVRTPGFRRVVSFGKVWGLFLYLLLWPFWWLLLKGTIHGAQSFFHAICSPEFASITQPVLVNECSIVEYSRKEITDPEFAEKLIKAADAQIDEVEKQYKKKKIKKSKK
Protein: Olfactory receptor 3A2 (Olfactory receptor 17-228) (OR17-228) (Olfactory receptor OR17-14) (P47893)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
Sequence:
MSLQKLMEPEAGTNRTAVAEFILLGLVQTEEMQPVVFVLLLFAYLVTTGGNLSILAAVLVEPKLHAPMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTISYDACLSQLFFFHLLAGMDCFLLTAMAYDRLLAICQPLTYSTRMSQTVQRMLVAASLACAFTNALTHTVAMSTLNFCGPNEVNHFYCDLPQLFQLSCSSTQLNELLLFAVGFIMAGTPLVLIITAYSHVAAAVLRIRSVEGRKKAFSTCGSHLTVVCLFFGRGIFNYMRLGSEEASDKDKGVGVFNTVINPMLNPLIYSLRNPDVQGALWQIFLGRRSLT
Protein: F-box protein PP2-A14 (Protein PHLOEM PROTEIN 2-LIKE A14) (AtPP2-A14) (SKP1-interacting partner 13) (Q9FJ80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000250}.
Interaction partners:
- Immune-associated nucleotide-binding protein 10
- Probable aspartyl protease At4g16563
- U-box domain-containing protein 45
- BTB/POZ domain-containing protein At2g30600
- At1g14330/F14L17_7
- Probable CCR4-associated factor 1 homolog 5
- F-box/kelch-repeat protein At1g15670
- U-box domain-containing protein 29
- Kelch repeat-containing protein At3g27220
- Probable BOI-related E3 ubiquitin-protein ligase 2
Sequence:
MGAASSSIVRSEPFAGKLCGLEDVPENCITAMFMYMEPPEICLLARVNKSFHRASRSDAVWEDKLPSNYKFLVRRILEDQQQVGVKDKLIYRKKEIYARLCRPNLFDTGTKEAWLDKRSGKVFLAISPKAMKITGIDDRRYWEHISSDESRFGSITYLRQIWWLEAVGKIRFEFAPGKYSLLFKIQLGKPIRKCGRKTCSLDQVHGWDIKPVRFQLSTSDGQCAMSERHLDESGRWVYHHAGDFVVENQNSPVWVKFSMLQIDCTHTKGGLCLDCVIICPFEYRGKYKYSD
Protein: FGF receptor-like protein 1a (Fgfrl1a) (Fibroblast growth factor receptor-like 1a (EC 3.2.1.76)) (Q7SX76)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Interaction partners:
- Fibroblast growth factor 8
- Fibroblast growth factor
- Sprouty-related EVH1 domain-containing 1.
- tRNA methyltransferase 1-like
- Fibroblast growth factor
- Fibroblast growth factor 23
- Fibroblast growth factor 3
- Fibroblast growth factor 17
- Fibroblast growth factor
- Sprouty-related EVH1 domain-containing 2a.
Sequence:
MELLWIVFFIFDIIFITDCARGPPRVAEKIAHRQTVRIGRTMKLQCPVEGDPPPLIMWTKDGRNIHSGWMRFRVLQQALRIKEVEADDAGTFICKATNGFGSVNINYTLIVIDDSSAGREGARPAGETEYSTDLTGKLVRPRFTQPAKMRKRVIARPVGSSVRLKCTASGNPRPDIVWLKDSRPLTPEEVGEGRKKKWTLSLKNLTPEHSGKYTCHVSNRAGEINATYKVEVIQRTNSKPILTGTHPVNTTVDYGGTTSFQCKVRSDVKPVIQWLKRVEPGGEGKYNSTIEVGDHHFVVLPTGDVWSRPDGSYLNKLLITRAKEEDAGMYICLGANTMGYSFRSAFLTVLPDPKPPFSPIPSVLPPSLPWPVIIGIPAGIVFILGTVLLWFCQSRKHCSSGAIISAQTLPNGHRQPPRDRPADKDCIASVAYEEYLAQQQQQQLLLAQSAPKVYPKIYSDIHTHTHSHVDGKIHQHQHIHYQC
Protein: Small ribosomal subunit protein uS2 (30S ribosomal protein S2) (P9WH39)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Interaction partners:
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein bS18B
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein bS6
Sequence:
MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTFIDKAYEFVKETVAHGGSVLFVGTKKQAQESVAAEATRVGMPYVNQRWLGGMLTNFSTVHKRLQRLKELEAMEQTGGFEGRTKKEILGLTREKNKLERSLGGIRDMAKVPSAIWVVDTNKEHIAVGEARKLGIPVIAILDTNCDPDEVDYPIPGNDDAIRSAALLTRVIASAVAEGLQARAGLGRADGKPEAEAAEPLAEWEQELLASATASATPSATASTTALTDAPAGATEPTTDAS
Protein: 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (P11043)
Organism: Petunia hybrida (Petunia)
Function: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate (By similarity). Involved in the accumulation of volatile benzoides in flowers, scent attracting pollinators (e.g. the night-active hawkmoth pollinator Manduca sexta).
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Interaction partners:
Sequence:
MAQINNMAQGIQTLNPNSNFHKPQVPKSSSFLVFGSKKLKNSANSMLVLKKDSIFMQKFCSFRISASVATAQKPSEIVLQPIKEISGTVKLPGSKSLSNRILLLAALSEGTTVVDNLLSSDDIHYMLGALKTLGLHVEEDSANQRAVVEGCGGLFPVGKESKEEIQLFLGNAGTAMRPLTAAVTVAGGNSRYVLDGVPRMRERPISDLVDGLKQLGAEVDCFLGTKCPPVRIVSKGGLPGGKVKLSGSISSQYLTALLMAAPLALGDVEIEIIDKLISVPYVEMTLKLMERFGISVEHSSSWDRFFVRGGQKYKSPGKAFVEGDASSASYFLAGAAVTGGTITVEGCGTNSLQGDVKFAEVLEKMGAEVTWTENSVTVKGPPRSSSGRKHLRAIDVNMNKMPDVAMTLAVVALYADGPTAIRDVASWRVKETERMIAICTELRKLGATVEEGPDYCIITPPEKLNVTDIDTYDDHRMAMAFSLAACADVPVTINDPGCTRKTFPNYFDVLQQYSKH
Protein: Roundabout guidance receptor 1 (A0A087WZ85)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEGNAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGNQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Protein: GAS2-like protein 2B (growth arrest specific 2 like 2 B) (A0A1L8H8C0)
Organism: Xenopus laevis (African clawed frog)
Function: Together with gas2l2.L, regulates ciliary orientation and performance.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30665704}.
Interaction partners:
Sequence:
MSTHQGGSVHSIRPFKSSEEYLYAMKEDLAEWLKDMYHLEIIVDNFIEILENGSVLCQHANNVTEVAREFFVQYPHLAEKLQLPKSGVKLNMMAQPGSFLARDNVSNFIQWCRKEMDIKDVIMFETEDLVHRKNEKNFLLCLLELARRASRFGMSAPMLIQMEEQIEEEIRQEMDLPPQEIPVPKPQRKLCDFKNLDQMVQNLVSRCTCPVQFSMVKVSEGKYRVGESSTLIFVRILRKHVMVRVGGGWDTLAHYLDKHDPCHCASLSHKPAIKLGSLQKQVSAVHEVKTQLTPRLDNPSKLETTLILSRSQSPLPPVEWRTYSAERTRTISSSYSLDDNENSPSFKNSQTPPNDRRSMSIGAHERSATLSRKLFTEDTQDPQQLGNPQSGHYRHHHSTSSLASQLTGSEEEYSYISEVFSESQSGRQMGKHTVMNLKEPPKRDAFLSHTQSANRKVISATQQNNIQQGLIIGHQSVTVQDSRPKTPSRFIQPPSPSKQIHFFYNQQNKGVEQNIKTQTNSCTRSSSPVKQTSLTYKQEFNKRPATPSRINYSSSQYKDGDKSAATEIITFHDHVRAKPSVSSEERTIRTGRATPTIHLNRENTNLPLKMQPKPNVTESSHSIERDCMYTPLPIDPEQEKQIYRSLEDEIRTNIKILEGDSEENNPENDTAAHDFNVLGKSTLRLSSSTSKTPRGQEGVPRSGVYINTAWQSGASYDDVITELTKGHVKLNNVDVENWISKIPLKGMVKEAHTSQRNKVRENGHTASLVRKKTLSTEMKGSKQKQLPSQIARQLALENKKKTVENVLEKQVSTVSGDSKEAIPEKIKLSQGLKPKKSLKKPERVPSIYKLKLRPKIRPRRDNRPEKKPSRIPTPVSYRQVPSRNNAKALKRTQSYQANKVSVAQTLNESQISAVNSEDLDSGDEICEHSAPLQAVETPITGENNQSRTEEEEESWV
Protein: G1/S-specific cyclin-D (Q9U2M5)
Organism: Caenorhabditis elegans
Function: In association with cdk-4, regulates the progression through the G1 phase of the cell cycle during postembryonic development. Regulates proliferation of the coelomocyte lineage and intestinal cells during late embryogenesis. In complex with cdk-4, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP).
Interaction partners:
- Cyclin-dependent kinase 4 homolog
- Retinoblastoma-like protein homolog lin-35
- Cyclin-dependent kinase inhibitor 1
- Cyclin-dependent kinase 2
- Runt-related transcription factor rnt-1
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase inhibitor
- G2/mitotic-specific cyclin-B1
- G2/mitotic-specific cyclin-B3
- E2F/DP family winged-helix DNA-binding domain-containing protein
Sequence:
MDFESSSAGPSTSYAEEPCTLSMLPQVSAVLSETSITESNVSCQLHPSRSAALNDNVRTLIYNRTDPHIQLDMRAFYNCMEYEEALQPNYHYFTGVQENITPFHREQAIDWIYDVAKEENCDGDVFLLAVSLIDRFMSVQNILKHDIQMIAGVALFIASKLKAPHPMTASKIAYYSDNSCPIDMILQWELLIVTTLQWETESPTAFSFFDFLASRIPQIHNMRGDFQTVVQKCQKMHKLATLFPSMQCAIGLYYVSNLPTQNKELAVKIKDLLANMFQLEVNLLDSYIPMVQRCMSTTPIYTSEDAEKTEPTPSAPASTQEPEAFQELKELKEEPLPTPPPEEPAFQKLVLLEPIPLSEQTPSTPLNDSGFSSDVSSPASSEKKRRRSTDWFEEDSTPPKIFKTL
Protein: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART) (P9WHM5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
Interaction partners:
- Phosphoribosylamine--glycine ligase
- Bifunctional purine biosynthesis protein PurH
- Phosphoribosylformylglycinamidine cyclo-ligase
- Bifunctional protein FolD
- Phosphoribosylformylglycinamidine synthase subunit PurQ
- Phosphoribosylformylglycinamidine synthase subunit PurL
- Phosphoribosylformylglycinamidine synthase subunit PurS
- Amidophosphoribosyltransferase
- Phosphoribosylglycinamide formyltransferase 2
- Serine hydroxymethyltransferase 2
Sequence:
MQEPLRVPPSAPARLVVLASGTGSLLRSLLDAAVGDYPARVVAVGVDRECRAAEIAAEASVPVFTVRLADHPSRDAWDVAITAATAAHEPDLVVSAGFMRILGPQFLSRFYGRTLNTHPALLPAFPGTHGVADALAYGVKVTGATVHLVDAGTDTGPILAQQPVPVLDGDDEETLHERIKVTERRLLVAAVAALATHGVTVVGRTATMGRKVTIG
Protein: Nucleoporin ASM4 (Nuclear pore protein NUP59) (Q05166)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). May have a mitosis control function (By similarity).
Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
Interaction partners:
- Nucleoporin NUP170
- Nucleoporin NUP157
- Nucleoporin NUP53
- Nucleoporin NUP159
- Nucleoporin NUP57
- Nucleoporin NUP188
- Nucleoporin NSP1
- Nucleoporin NUP49/NSP49
- Nucleoporin NUP192
- Nucleoporin NUP145
Sequence:
MFGIRSGNNNGGFTNLTSQAPQTTQMFQSQSQLQPQPQPQPQQQQQHLQFNGSSDASSLRFGNSLSNTVNANNYSSNIGNNSINNNNIKNGTNNISQHGQGNNPSWVNNPKKRFTPHTVIRRKTTKQNSSSDINQNDDSSSMNATMRNFSKQNQDSKHNERNKSAANNDINSLLSNFNDIPPSVTLQDWQREDEFGSIPSLTTQFVTDKYTAKKTNRSAYDSKNTPNVFDKDSYVRIANIEQNHLDNNYNTAETNNKVHETSSKSSSLSAIIVFGYPESISNELIEHFSHFGHIMEDFQVLRLGRGINPNTFRIFHNHDTGCDENDSTVNKSITLKGRNNESNNKKYPIFTGESWVKLTYNSPSSALRALQENGTIFRGSLIGCIPYSKNAVEQLAGCKIDNVDDIGEFNVSMYQNSSTSSTSNTPSPPNVIITDGTLLREDDNTPAGHAGNPTNISSPIVANSPNKRLDVIDGKLPFMQNAGPNSNIPNLLRNLESKMRQQEAKYRNNEPAGFTHKLSNWLFGWNDL
Protein: Muscarinic acetylcholine receptor M3 (P08483)
Organism: Rattus norvegicus (Rat)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1527051}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P20309}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P20309}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. {ECO:0000250|UniProtKB:P20309}.
Interaction partners:
- Guanine nucleotide-binding protein G
- Metabotropic glutamate receptor 5
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit gamma
- Muscarinic acetylcholine receptor M1
- Muscarinic acetylcholine receptor M5
- Guanine nucleotide-binding protein subunit gamma
- Kininogen-1
- Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit alpha-15
Sequence:
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
Protein: Zinc fingers and homeoboxes protein 3 (Zinc finger and homeodomain protein 3) (Q80Z36)
Organism: Rattus norvegicus (Rat)
Function: Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17056598}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:17056598}.
Interaction partners:
- RAB5 interacting factor
- Probable ATP-dependent RNA helicase DHX35
- TBC1 domain family member 31
Sequence:
MASKRKSTTPCMIPVKTMVLPGASTEAQPVEPLPEGPQQDLPSEAPEASSEAAPNPSSTDGSALANGHRGTLDGYVYSCKECDFRSQDVTHFVGHMTSEHTDFNKDPHFVCTGCSFLAKTPEGLSLHNAKCHSGEASFLWNVTKPDNHVVVEQSVPENASSSVLAGESTEGTEIIITKTPIMKIMKGKAEAKKIHMLKENAPTQPGGEALPKPLAGETEGKEGDHTFINGATPVSQASANSTKPPHTANGPLIGTVPVLPAGIAQFLSLQQPTVHPQHHPHQPLPTSKALPKVMIPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISWSPEEIEDARKKMFNTVIQSVPQPTITVLNTPLVASAGNVQHLIQAALPGHAVGQPEGTAGGLLVTQPLMANGLQASSSSLPLTTASVPKPTAAPINTVCSNTTSAVKVVNAAQSLLTACPSITSQAFLDANIYKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLKGTRAMVPGEHGSVLIDSVPEVPFPLSSKVPEVPCVPTATSLVSHPATKRQSWHQTPDFTPTKYKERAPEQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKRVNAEETKKADGHAPQEEAEGAEEEGRDEELASELRAPGENGSSEMFLSHTLAERKVSPIKINLKNLRVTEASGKSELPGMGMGVCEPEEDGLNKAVEQPPSRVSYKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLLVIAPGNRELLQDYYMTHKMLCEEDLQTLCEKTQMSAQQVKQWFAEKMGEETRAVADTSSEDQGPGHGEPVAVDKVLGDACAALSENSEAWEPSAPEAGSEPFDTSSPQSGRQLETD