Protein: Methylcytosine dioxygenase TET (EC 1.14.11.80) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase) (EC 1.14.11.51) (M9NEY8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is present at a relatively high level at the very earliest embryonic stages but at low levels at the late embryonic stages and may act as a regulator of gene expression. Promotes differentiation of early germ cells in ovary. Contributes to neuronal morphology, development, and function in the brain. By interacting with histone modifier wds, binds to a specific set of genes, modulates intragenic (N(6)-methyladenosine) DNA levels and thereby maintains transcriptional activation. Also able to catalyze the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).
Subcellular location: Chromosome {ECO:0000269|PubMed:30078725}.
Interaction partners:
Sequence:
MASSILAQSSTGATVDSSNLGATAAAATSVEATVSSLHNTHLNQLSSLSQHYTTPYHHPHSHSHPHHHYQQHYPQQQHLQQQQQQQHHAQQQHQQQQQQQQQQQQQHWDYYARQQQQHQQQQQQQQQPAAATGNTNGNSSNNGNNGNNGNNSNPDGSNTTVPAPLGSSNNSSSNHANAASGGNSGQRHGDANANAISAASAAVGNPGNQQPNNSAGNANSNSNSNSNSNGSYTRPWEMESKDNGPQPPQTQPHLQLKSGFEPFSKLPSFQSQFHGFNEQLLPDGTPMPVPIGAGVPPGSAAAVAAATGSIPPGSVGPNSVAGPVGPTAMSSLQTVAMSPASISVSSPGMMSVGSPLTQLSSLQTSITPPSAGSFPAPPPPNAFAHHHALNPHHHHRGASGYPTPYAELPLYPGFTPLSVKKEPISGGSDFEMLLKKEDFDLSNSGGAGLIHHPLQHGQPHPIPMGMHTPTSYDGNNSNNSYPQAAGGGSGSHTPHTTTTQPTPTTTTPVKVEKLLQSPIARLEARKKERRKQRPNSLESSAESEASGMDVDPSNPGQVDAVSSTANFKSPLSALGMGDSNDANASGCDKQSKKKRKRCGECVGCQRKDNCGECAPCRNDKSHQICKQRRCEKLTEKKIVFGADGQPVRPDSKRGRGKGKSSGSGNGTVNATGIAAGNGTPTTGQSRARKNSTKANKLNAAAASATSPRLSPVPAATLLPQQSPNTTSATGNLQQQQQQQQQQYQQHQQLLSQQQLLSQQQQQYQQPQQQQQHFQQQQQQHLQQQHAQQQHLPQQQHQITAQIQTMKDQPQQPMAPMAFYPTWQADPSQGWQNQFIQQIPQNTPAITSLNSLDFQTQSYAYPSNGYVQSGLGFDPNYGRSPYAAPVQRYDFQSQQLSTAPSAINQVGLQSVAGFAPSYAGQVSAAPVPPSQQQQQQQQQQQQQHLGADLNKTMSGNDTPGYPRVSSVPPRSLNCNGYSGDYSGSPATNSNSNNNSSSNTSNTNNSNASNNNATTVVSGGTTTPAPPPTVVAQPASSPMQPPNQAVPQSPTRSNMLQQQQQQHQSPTGNGLQPYVAPQQQQQQQQQQHLSSPPMQDWNWQQQQQQQQSLGGEGYAQGERLHLNTRIKSMIMRKSDPKDPPPDLQQQPQQVQQQQQTGHFLSYSHHLRPEAALSANGPSSATPTHPLPNLQQQQQQVQQVQQVQQQQQQQQAVGGQVAAEPIGGGGDHIWKPHHANSFKKPSVVSGYPASQDAQLQLQLQQHQPGQHTTINHSVDPPVVPPQQHPPVAAAQPKKSRSRSKASRAAAAAAAAAEAAAEIDRDRNSTDPGGGGLKPLSAHYPPHPHAAGGPPPGQDYHSQYIKTEPGLLGPPQPNKMEGYERNYQNFIQYADFCQNDGQGQPVQQHHGHGQQDYAGYHHNSAYYGAGASSFQQNFQQNFVPGYQHSTYGARGKPPANQPHQIHGHGQSLMELDRKPDTNSIIPLPTNYEKDIPAYPIPPHRYALGHGAPPHLSHHGMLEPKIEDMGMLGHGGGYAYLGSEGKPLNNGFSCCRQGGTRPPTAEHLKDGTCLGLGIQPKEELIDEDELIDTHGNGLKPIGGVGKAKGKQKPDEIPEIVVKHEKINPMFDTTDRLEKGNKTEIPECECFQSDKNPPEPGTYYTHLGTASSLMDLRREFEERCNLTGRQLRIEKIVYTGKEGKTSQGCPVAKWVIRRADLEEKILVVVKKRPGHRCIAAYIVVCMVAWDGMPRLEADNAYKNLIPKLNKYGLPTTRRCATNENRTCACQGLDPESSGASYSFGCSWSMYYNGCKYARSKTVRKFRLSVKSEEAAIEDHMNLIATLLAPVFKQVCPRSYDNQTKYEHEASDCRLGLEPGKPFSGVTACLDFCAHSHRDLHNMQDGCTVHVALLKPGNRDTRLPDDEQFHVLPLYTMDGTDEFESVEGQRDKHRTGAVQMLDKFPCEVRVRSTPLIPCRRHGKKRKDGDEAAPPDGDQDAVGDANSQSSSSNGAQSQTQANNQQSSPPALGTAHIKKENGNGVNANGASSKSKGKGKSNQSNNSSASTPGSAPPSTPSPRCQTPVTNNPSPAGSAFSTPPVHGSNANPQSNGGQGTGNQPGQLMSSNSSLMNMATMIDTFTDAQLQSNQISSTVLDSPYSYDYQTASYIDSRNYYGQWPTPHAPMGMQAQVGGLGGGGPGGTVAGVPPLTPSTPTAQPQLGVPPATSIAGGTTTGAPTGALPATAPPTATPTQLETSNGYGPGNYQTLVSNPASNLTNPGGVTTEVQQQHQQAQQQSALTGGVGPGGLPVVGGAPGDLKGRLVSEENPDSTTLVNHHHHHHNLTESKLTALTAMQPMTNLAPLTTSHHPQEGFVKPKPPPSDYTAQYTAQYPNNYQMYPPPPPPPHSAYSAYDAYQNMNYNYGYHQAYSPYGMYPQQTPPPTPPPPSPNWNMYGHHQTGSVNSGYGSANPAAGAGSLISSHGSVASAGVGLQKAMVPVPGPLHHQQQQVLQQQQQQQQQQQQQQQQQQQQQQQQVQQLQQEAPQTILPDLSNGQTNSDTVATPTPTGDSSSNDAGPGNPGAGNQAPASGAGAATTAPPIASPGSTNSTKIEPIGEVAEINENIEAFQDPQMGGVAIALNHGSVLIECAKHEMHATTAVRRPDRHHPTRMTLIFYQHRNLNRCRHGIDEWEEKMRVKKINTDLDNKAKEERERLIKKAAGEDMDELDEDALMQDEPVPIKKESSANGQQLKNGASGSKKKKSSDSKKSQANEQSKNEKVALHAPTLTTTSWTTLFPTHPCVVSGKYPEGNSSPTSSTNNAPNGGGCPAQQQQHLPPPPGSGLIHPPPGTPTGTAAPPPLPTPHQQLPQQQQT