wanglab/gogpt-training-data huggingface dataset:
Protein: U3 small nucleolar RNA-associated protein 15 C-terminal domain-containing protein (Q581Y4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Interaction partners:
- U3 small nucleolar RNA-associated protein 18
- AATF leucine zipper-containing domain-containing protein
- Bystin, putative
- U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein
- Small-subunit processome Utp21 domain-containing protein
- Bms1-type G domain-containing protein
- KRR1 small subunit processome component
- U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein
- HEAT repeat-containing protein 1
- BING4 C-terminal domain-containing protein
Sequence:
MQNKSWALPIKQVPVVEKLDRSIVWNNVRLCYEQKLFGQISCIRYNNAGTVVGCASTNQLSLLRVPQTEGVITNEQRERKCFSLRFRDDDKMTIMSVDQRVVIRSTETLFERQFPGHVREVRDALFLDRRSFVSGSDDTTIKLWDVMGECELAVGKAHTDYVRCLENRSPGCFFSGSYDHVINLWDTRAGFSCPTQTSGQAVPNPVESLLCLDTNLLVCGASDQIILFDIRKGLSLPLTQDSYHTKTVVALGYSKKYNVLLSGSLDQRVKIFSLERGCPDPVASKKFDAPVTAVAVHPRSSEFAVGTASGDLRIMKLGSASDGDEMGGGKDEESRGRQKDEELIAMKVNDVRRQLVSYQYNRALKTALYSRHADVVVSTLEELLRRGALHVALSGQNDRTIARILRFALGFIDTPQFCESMMVVLDTIFDIYGTCVGKSIFLHRELMKAHRRLGSVLANLQRMAGTLSIMELIVNDV
Protein: 17.8 kDa heat shock protein (OsHsp17.8) (Q0DY72)
Organism: Oryza sativa subsp. japonica (Rice)
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MSLVLSRMLLDRFFPGAGGVVAGEARPPMDWRETPVAHVFEMDLPGLAKDQVAVEVVDGHILRVRAGGEHEDANNAAKAGKASGEEEEENDGVRWHCRERAAGRRRAAVTQFRLPEDAAADEASARMADGVLTVTVPKRKGKKRHAGNGKAAGDDKPVCCRFWP
Protein: DNA-directed RNA polymerase subunit (Q5A8Y7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369086}.
Interaction partners:
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase core subunit
- DNA-directed RNA polymerase II core subunit
- DNA-directed RNA polymerase II subunit
- DNA-directed RNA polymerase subunit
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerase subunit beta
Sequence:
MFFLKDLSLNLTLHPSFFGPQMDQYLREKLLSDVEGTCTGQFGYIVCVLDSMNIDVGKGRIIPSTGMAEFEVKYRAVVWKPFKGEVVDAVVTTVNKMGFFADVGPLSVFVSTHLIPSDMKFNPSANPPAYVSPDENIEKGSRVRLKIVGTRTDVNEIYAIGSIKEDYLGPSPM
Protein: C2 domain-containing protein (Q54T13)
Organism: Dictyostelium discoideum (Social amoeba)
Interaction partners:
Sequence:
MTIPFGKVVIKILGARDTLICDITTSDPYCLISTKDSKTFKTEVIYKTLNPVWKDEEFVFDVIENSQIISILMYDEDKFSKDDFMGLVRINIDEYKTKGQRDIWIPLEGKNPNKKAKKRGDIHIQLCYYSFTSLTNYLIKNNHSLIIKLSKQLISDDFGKAIMYYFSNCSESGKELIDIVRDLASIEIEQTNDAKVLFRTDSLSTKVIVSIFKTIGFGYLKEALCPLIMSMIKNDINLEVDPSKGGITEAEVEQNAIQLSFFCSSFITAIKASLADQLPIEIRQICQIINQLVEKKYPNDNIKSVGGFFFLRFVNPAIFSPEALGLISVAPNSNVRRTLTLVSKILQNISNQVTFSSGKEEYLSSFNNFISSRFDDFKIILQEVSSFNDNNNNNNELQLFKNLKIDSNLLMKYTDTIITLISEKKQNLIDNDDNQFNDEILSRYQLILSQQKQEPKILIEKSKK
Protein: Allatostatin C, isoform A (GEO08325p1) (RH36507p) (Q9VKK5)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
- Short neuropeptide F
- Neuropeptide CCHamide-1
- GEO08248p1
- Allatostatin-A
- Neuropeptide F
- Allatostatin double C, isoform C
- Cardioactive peptide
- Allatostatin C receptor 2, isoform F
- Ecdysis triggering hormone
- Trissin
Sequence:
MMKFVQILLCYGLLLTLFFALSEARPSGAETGPDSDGLDGQDAEDVRGAYGGGYDMPAQAIYPNIPMDRLQMLFAQYRPTSYSAYLRSPTYGNVNELYRLPESKRQVRYRQCYFNPISCFRK
Protein: ADP-ribosylation factor-binding protein GGA1 (Q23165)
Organism: Caenorhabditis elegans
Subcellular location: Early endosome {ECO:0000256|ARBA:ARBA00004412}. Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004150}.
Interaction partners:
- FYVE-type domain-containing protein
- small monomeric GTPase
- ADP-ribosylation factor 6
- Putative stoned B-like protein
Sequence:
MEEEPVRPIDYWVCRATDRFIGDEERIKALDFIIESIYKQPASALLAVDLFSHKLSSPSQEEAMLTIRALDYLVRNGGEKVHERCGRYKFLNELVRLIAPKYNGKLTSDALKTEIIKLLFIWQLSIKHIPKYKQVYESLKLSKIITDDPHVRETEVPVFAVPPVRSSVFDNEEQAVLLKALLSSNRPEDLETANNLIKTLVETEEHKLVKIHERRKKLDHAINLCNQVEHLRLDKAAETIGLGNYSPDNELTLQRVTNELIQLQELFYGYVNELAENNDPCLEEVLNINDQINRVLPENETPKCGNRAPISARTQLDPENQELLVFNTPTSEVPPKNGFCDPRDLEGSLLNNMIESEFVEEPKIVPVQQMTPVLNRNSSASPRASGDSSIFETDFLAGKRLPEPLKPPTLNELKPNTTTITLEALEVLVPPMSPEPTSLSPKAIPEKVALNPSSIIMRNRVPIEVLYSKGMRILLYYCQSDMTVSNIHSYVLVIQNHNNFTIKDVNLSLKTNDKNVIIRLQDSVNNLAGFNIFGQQETINLLLCIQQLNDVKDVELDFTLAYKKSLESAISGSFTLPIIPEHIFNINF
Protein: Forkhead box protein E1 (Thyroid transcription factor 2) (TTF-2) (Q8R2I0)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O00358}.
Interaction partners:
- Paired box protein Pax-8
- Homeobox protein Nkx-2.1
- Thyroglobulin
- Thyrotropin receptor
Sequence:
MTAESAPPPPPQPETLAAVKEERGEAAAAGAGVPAEAAGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAIFPGAVPAARPAYPGAVYAGYAPPLAAPPPVYYPAASPGPCRVFGLVPERPLSPDLGPAPSAAGGSCAFAAAAGAAGTGSFQPAVCTGARPVNPAAYAAAYAGPDGAYPQGASSALFAAAAGRLAGPASPPAGGGSGGVEATVDFYGRTSPGQFGAALGPCYNPGGQLGAGGGGAYHSRHATAYPGAVDRFVSAM
Protein: Large ribosomal subunit protein eL34 (60S ribosomal protein L34) (P49207)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q29223}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q29223, ECO:0000269|PubMed:25957688}.
Interaction partners:
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein eS26
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS14
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein eS27
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein eL31
Sequence:
MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGVRAVRPKVLMRLSKTKKHVSRAYGGSMCAKCVRDRIKRAFLIEEQKIVVKVLKAQAQSQKAK
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q38CM7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Interaction partners:
Sequence:
MTVQACNSVSGTTIRSGMKSVATALLFLCVVRPAGASDGTAVAAVSDECGEIAYLQHLKSHDSRVAGDAAQSVATLTHEAHILTLAAEKHHGTINGAKYAFLAAIAADAKTEAVQTKLSQAAGPITSTAAERARRKGQLKALRHLNQATTAEYGETAVKAGTPTTIIGSADLGVTVKMQLNTAKADKCFLEATEPADIKNIVSEIANNDNYKGVDDSSFRPPQAELQMASRGNSPASMTNCERGRCCGDGAAMTSTNFLGLGTATKGQANTLTASTEPFKAGNQCTSPKKATSGDEAVINRKRTAHYLCNARQIQTQTTSSIKQTTVGQLRASEKANRLALAALGQTPKEGDNEQGKNAVKKLLGTDDSKTLDKFFSALETVDLQLSQDKGASKTSIKAAGESDNYGFALAYFSGQALKRTEEAAKSVTKATQAKEDDCTGKKRTECKGECELDGEICKPKKKEDGENKEKTGTTNTTGSNSFVIKAPILLALSLRA
Protein: Signaling mucin MSB2 (Multicopy suppressor of bud emergence 2) (Osmosensor MSB2) (P32334)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. Partially redundant with the SHO1 osmosensing branch for the activation of STE11.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15256499}; Single-pass membrane protein {ECO:0000269|PubMed:15256499}. Note=localized to polarized sites on the cell surface.
Interaction partners:
- High osmolarity signaling protein SHO1
- Cell division control protein 42
- Protein OPY2
- Cell division control protein 24
- Aspartic proteinase MKC7
- Aspartic proteinase 3
- Signaling mucin HKR1
- Serine/threonine-protein kinase STE20
- Serine/threonine-protein kinase STE11
- MAP kinase kinase PBS2
Sequence:
MQFPFACLLSTLVISGSLARASPFDFIFGNGTQQAQSQSESQGQVSFTNEASQDSSTTSLVTAYSQGVHSHQSATIVSATISSLPSTWYDASSTSQTSVSYASQESDYAVNQNSWSASTNQLPSTSTTSYYAPTFSTSADFAASSVNAASDVSTASVPIDTSANSIPFTTTSNIETTTSAPLTSDTPLISTSTMSAADNVFSSANPISASLTTTDSSESFDQTSTAGAIPVQSSADFSSSSEILVQSSADFSSPSSPTTTDISLSAAPLQTSESSSFTTASAALPVSSTDVDGSSASPVVSMSAAGQIASSSSTDNPTMSETFSLTSTEVDGSDVSSTVSALLSAPFLQTSTSNSFSIVSPSVSFVPSQSSSDVASSSTANVVSSSFSDIPPQTSTSGSVVSVAQSASALAFQSSTEVYGASASSTMSSLLSTTSLQSTTLDSSSLASSSASSSDLTDYGVSSTASIPLLSASEQASTSSSFSVVSPSVSFVPSQSSSDVASTSAPSVVSSSFSYTSLQAGGSSMTNPSSSTIVYSSSTGSSEESAASTASATLSGSSSTYMAGNLQSQPPSTSSLLSESQATSTSAVLASSSVSTTSPYTTAGGASTEASSLISSTSAETSQVSYSQSTTALQTSSFASSSTTEGSETSSQGFSTSSVLVQMPSSISSEFSPSQTTTQMNSASSSSQYTISSTGILSQVSDTSVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTSVPSTSSRSSVSQVSDTPVPSTSSRSSVSQTSSSLQPTTTSSQRFTISTHGALSESSSVSQQASEITSSINATASEYHSIQTTAATQSTTLSFTDANSSSASAPLEVATSTPTPSSKASSLLLTPSTSSLSQVATNTNVQTSLTTESTTVLEPSTTNSSSTFSLVTSSDNNWWIPTELITQAPEAASTASSTVGGTQTMTLPHAIAAATQVPEPEGYTLITIGFKKALNYEFVVSEPKSSAQIFGYLPEALNTPFKNVFTNITVLQIVPLQDDSLNYLVSVAEVYFPTAEIEELSNLITNSSSAFYTDGMGTAKSMAAMVDSSIPLTGLLHDSNSNSGGSSDGSSSSNSNSGSSGSGSNSNSGVSSSSGNSYQDAGTLEYSSKSNSNVSTSSKSKKKIIGLVIGVVVGGCLYILFMIFAFKYIIRRRIQSQEIIKNPEISSISSSEFGGEKNYNNEKRMSVQESITQSMRIQNWMDDSYYGHGLTNNDSTPTRHNTSSSIPKISRPIASQNSLGWNEV
Protein: LYR motif-containing protein 4 (Q9HD34)
Organism: Homo sapiens (Human)
Function: Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:17331979, ECO:0000269|PubMed:19454487, ECO:0000269|PubMed:23593335}. Nucleus {ECO:0000269|PubMed:19454487, ECO:0000269|PubMed:23593335}.
Interaction partners:
- Cysteine desulfurase
- Frataxin, mitochondrial
- Iron-sulfur cluster assembly enzyme ISCU
- Acyl carrier protein, mitochondrial
- Ferredoxin-2, mitochondrial
- Stress-70 protein, mitochondrial
- Cytoplasmic aconitate hydratase
- Adrenodoxin, mitochondrial
- Iron-sulfur cluster co-chaperone protein HscB
- Glutaredoxin-related protein 5, mitochondrial
Sequence:
MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQVHIGQLYSTDKLIIENRDMPRT
Protein: Ranacyclin-T (P83719)
Organism: Rana temporaria (European common frog)
Function: Has antibacterial activity against Gram-positive bacteria B.megaterium Bm11, S.lentus and M.luteus, and Gram-negative bacteria E.coli D22, Y.pseudotuberculosis YP III and P.syringae pv tabaci, and antifungal activity against C.albicans ATCC 10231, C.tropicalis, C.guiller-mondii and P.nicotianae spores. Has weak hemolytic activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P83663}.
Interaction partners:
Sequence:
MFTMKKTLLVLFFLGVVSLSLCVEERDADEEDGGEVMEEEVKRGALRGCWTKSYPPKPCKGK
Protein: Fibrillin-5, chloroplastic (Plastid-lipid-associated protein 7) (Q5M755)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential for plastoquinone-9 (PQ-9) biosynthesis. Interacts with the diphosphate synthases SPS1 and SPS2, and binds to the hydrophobic solanesyl moiety, which is generated by SPS1 and SPS2, in FBN5-SPS homodimeric complexes to stimulate the enzyme activity of SPS1 and SPS2.
Subcellular location: [Isoform 1]: Plastid, chloroplast stroma {ECO:0000269|PubMed:22274653, ECO:0000269|PubMed:26432861, ECO:0000269|PubMed:29741733}.
Interaction partners:
- Probable plastid-lipid-associated protein 8, chloroplastic
- Solanesyl diphosphate synthase 2, chloroplastic
- Solanesyl diphosphate synthase 1, chloroplastic
- Probable plastid-lipid-associated protein 13, chloroplastic
- Probable plastid-lipid-associated protein 9, chloroplastic
- Probable plastid-lipid-associated protein 12, chloroplastic
- Probable plastid-lipid-associated protein 10, chloroplastic
Sequence:
MTSNLFQPPSMAASRGAISRRTGNVKVLVSFTSSNGKTLSFSDNSFRLRPMFIGKVTEQSSCSSPNEQQQDEEQEQEQEEITVSHIKEELYEALKGINRGIFGVKSDKKTEIEGLVKLLECRNPTPEPTGELDKIGGCWKLIYSTITVLGSKRTKLGLRDFVSLGDLLQQIDIAQGKTVHVLKFDVRGLNLLDGEFRIVASFKISSKSSVEITYESSTIKPDQLMNIFRKNMDLLLGIFNPEGLFEISYLDEDLQVGRDGKGNVFVLERIEKP
Protein: Uncharacterized protein (Q389C0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Interaction partners:
Sequence:
MDSVCPERSVTCVTWNHDGSNLAVGLRCGFIIYSTELLHLVDGKLFEILFQPVDGGAGLIALHGQCNLVFISGWAYDHRATVAIYDLSVKGEEHDSRDRAVLAKVTMAEAVNGLCFHPLLVMVGTESGLVHVFNQKLEKIQEYKTSQKIRTFAGATSKMALGTMLDKEVAGGVNYLLLRGVVAGPTPGSVRCIRYVSERSMEVESSQSSLEEEGGCAAGPLEENVVELHTAEVQCIAITVDGRCAVTVSARGTMLKLLDVRKGVVIGQYSRGAAPNTVLSLALHQWIDRTVLTCISDSGTLHIFHGPPLKRSSEHHETADTTTDAKWSVPVVQRFNDYISSVGAKFRITIPEDGLSDVHCRERLDVGMAYSTVVRIHDASLSPTILVAQRYIKRDGTSSKGRLLFIKVDMAAEVPGVARTKDLRSFYFPKSEM
Protein: Deubiquitinase SseL (Deubiquitinating enzyme) (Deubiquitinating protease) (Salmonella secreted effector L) (A0A0F6B423)
Organism: Salmonella typhimurium (strain 14028s / SGSC 2262)
Subcellular location: Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Interaction partners:
Sequence:
MSDEALTLLFSAVENGDQNCIDLLCNLALRNDDLGHRVEKFLFDLFSGKRTGSSDIDKKINQACLVLHQIANNDITKDNTEWKKLHAPSRLLYMAGSATTDLSKKIGIAHKIMGDQFAQTDQEQVGVENLWCGARMLSSDELAAATQGLVQESPLLSVNYPIGLIHPTTKENILSTQLLEKIAQSGLSHNEVFLVNTGDHWLLCLFYKLAEKIKCLIFNTYYDLNENTKQEIIEAAKIAGISESDEVNFIEMNLQNNVPNGCGLFCYHTIQLLSNAGQNDPATTLREFAENFLTLSVEEQALFNTQTRRQIYEYSLQ
Protein: Abelson interacting protein, isoform A (Abelson interacting protein, isoform B) (Abelson interacting protein, isoform F) (Abl tyrosine kinase-interacting protein) (LD37010p) (Q9Y0S9)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Interaction partners:
Sequence:
MLTETPMASENIMDELASLIRTEIPDGRQSLRDSYTNLERVADYCEDTYYRADNKKAALEATKNYTTQSLASVAYQINTLAYSYMQLLELQAQQLGEMESQMNHIAQTVHIHKEKVARREIGVLTANKVSSRQFKIVAPINPEKPIKYVRKPIDYSMLDEIGHGINSAQHSQVRQKHRGSSHGSVQSLLPPSVGPPPTTKPPTPPQMSRAGNTGTLGKSVSNTGTLGKSSREYRTPPVVNPPQVPSHYAPNYPIGHPKRMSTASSTMTTTTTGGGAAGNERAAGYSALPMPPSQQIATHVNLPSAGMMQSLPPPPPTTYDDRSSMPPAPPSPLTVSQHEMTEQSHIGMHTLGRNINRNHFSLNFARPGSQSPPLPPPPPPEDEHQDFGRPRTSTGPQLAPIVPEDQNLPGWVPKNFIEKVVAIYDYYADKDDELSFQESSVLYVLKKNDDGWWEGVMDGVTGLFPGNYVEPCV
Protein: Alanyl-tRNA editing protein AlaX-M (AlaX-M) (Alanyl-tRNA deacylase AlaX-M) (Q97ZX2)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala).
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
- Tetratricopeptide repeat protein
- Uncharacterized protein
- Uncharacterized protein
- Tetratricopeptide repeat protein
- Isoleucine--tRNA ligase
- Valine--tRNA ligase
- Leucine--tRNA ligase 1
- Leucine--tRNA ligase 2
- Histidine--tRNA ligase
- glycine--tRNA ligase
Sequence:
MTEELYLKDSYIKEFEGRVVRIEGNYVILDKTAFYPGGGGLDNDTGFLVNEKGERISVTEVKRGENGEILHKIDQNGSLNVNEKVIGTIDWDRRYRMMRLHTASHIVAALAYRKFGALITGGHISPEQAKDDFNVENKDTLIELINEANEIIKKDIELKIYFLPREEALMIPAIVKLAGRNPPQIPIWRIVEIPGIDIQADGGPHVKNTKEIGEIVLLKVENKGKGRKRVYYTVKP
Protein: Interferon regulatory factor 2 (IRF-2) (P14316)
Organism: Homo sapiens (Human)
Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Subcellular location: Nucleus.
Interaction partners:
- Interferon regulatory factor 2-binding protein 2
- Interferon regulatory factor 1
- Interferon regulatory factor 2-binding protein 1
- Probable E3 ubiquitin-protein ligase IRF2BPL
- Interferon alpha-1/13
- Signal transducer and activator of transcription 2
- Interferon beta
- E3 ubiquitin-protein ligase Mdm2
- Transcription factor PU.1
- Gasdermin-D
Sequence:
MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTVNIIVVGQSHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAESETTDSVPSDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIKEESNPVPYNSSWPPFQDLPLSSSMTPASSSSRPDRETRASVIKKTSDITQARVKSC
Protein: Protein enabled (Q8T4F7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Functions, together with Abl, trio and fra, in a complex signaling network that regulates axon guidance at the CNS midline. Required in part for robo-mediated repulsive axon guidance. May be involved in lamellipodial dynamics.
Subcellular location: Cell projection, lamellipodium {ECO:0000269|PubMed:14762109}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14762109}. Note=Expressed at the leading edge of lamellipodia. Colocalizes with chic at the periphery of cells.
Interaction partners:
- Zyx102 protein
- Tyrosine-protein kinase Abl
- Roundabout 1, isoform A
- Profilin
- Testin
- LD06925p
- Neurofibromin 1, isoform B
Sequence:
MAMKKLYAKTSFTSKKPSSAANSTPILAYHQQQHQQPGNGICEFQVVAPGHSGELMIRRSQSMHHKMSPPVGGLGSKSEYYSIEELQELDLLDYRHPMYHHYQQQELRQRYHEHEQLVLQLPKATSPKAGPIYEAPQRSQQQQDQMLYVPTAAQRDSSSSAAATSIASSSTLTSSPSPSSSSSLIFSTLRKCVSPSNPSVNPNQPSKTQPSKLGCSMSFSIRTTTATAATAAAANAATATLSTQQQQQQAQQQHKQHLYSNIHHYLIRQQQQKQHYTLQRRHNSVKDKFIGGITTIFAEQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCSILKGLKYNQATATFHQWRDSKFVYGLNFSSQNDAENFARAMMHALEVLSGRVANNPGGPPTNGNGYEEDMGYRTMTSEDAAILRQNNSIGGHVTPSAQTPTSQTNQNNIPQSPPTPQGHHRTSSAPPAPQPQQQQQQQQAQQMGQPGSHYGPTGNGPTSNGLPQQVNSQIPPAPQQQPQQQQFQQQQQQQQYQQMVQAGYAPSQQYQQPHYVLSNSNPNLTVHQYPTQQAQQQPPQAPQPPLQNGGMYMVGHGHLPSSASANSVVYASQQQMLPQAHPQAPQAPTMPGPGYGGPPVPPPQQQAENPYGQVPMPPPMNPSQQQQPGQVPLNRMSSQGGPGGPPAPAPPPPPPSFGGAAGGGPPPPAPPQMFNGAPPPPAMGGGPPPAPPAPPAMGGGPPPAPGGPGAPPPPPPPPGLGGAPKKEDPQADLMGSLASQLQQIKLKKNKVTTSAPENSGSSTSSGGSGNYGTIGRSSNGMASMMDEMAKTLARRRAQAEKKDPDPEAEVKKRPWEKSNTLPHKLSGGAGSGSAGSGHEGANGNSGGAGSNTTNSGGESPRPMRKRFGSASEETILKVNGDGLSLALSNGDLDTLKAEIVREMRLEIQKVKNEIIDAIKSEFNRR
Protein: Neuraminidase (EC 3.2.1.18) (H6QM85)
Organism: Influenza A virus (A/little yellow-shouldered bat/Guatemala/164/2009(H17N10))
Subcellular location: Host membrane {ECO:0000256|ARBA:ARBA00004597}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004597}. Virion membrane {ECO:0000256|RuleBase:RU361252}. Host apical cell membrane {ECO:0000256|RuleBase:RU361252}; Single-pass type II membrane protein {ECO:0000256|RuleBase:RU361252}.
Interaction partners:
Sequence:
MSINGTTCLLTLSLILNVIMIGLQILMPFILLWTNSPPPEISNSTSCCNGTFLNETNNNITNISQITNNFLKEEKFYWRAKSQMCEVKGWVPTHRGFPWGPELPGDLILSRRAYVSCDLTSCFKFFIAYGLSANQHLLNTSMEWEESLYKTPIGSASTLSTSEMILPGRSSSACFDGLKWTVLVANGRDRNSFIMIKYGEEVTDTFSASRGGPLRLPNSECICIEGSCFVIVSDGPNVNQSVHRIYELQNGTVQRWKQLNTTGINFEYSTCYTINNLIKCTGTNLWNDAKRPLLRFTKELNYQIVEPCNGAPTDFPRGGLTTPSCKMAQEKGEGGIQGFILDEKPAWTSKTKAESSQNGFVLEQIPNGIESEGTVSLSYELFSNKRTGRSGFFQPKGDLISGCQRICFWLEIEDQTVGLGMIQELSTFCGINSPVQNINWDS
Protein: Protein bowel (Brother of odd with entrails limited) (Q9VQU9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Putative transcription factor. Required for leg joint formation, acting downstream of Notch to pattern the leg tarsal segments. Functions in the terminal pathway during embryogenesis, acting downstream of tll in the posterior of the embryo. Acts in a hierarchy downstream of drm and lin during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut. Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus.
Subcellular location: Nucleus {ECO:0000305}.
Interaction partners:
- GH13213p
- Pre-mRNA-splicing regulator female-lethal
- Segmentation protein even-skipped
- Segmentation protein paired
- Segmentation protein fushi tarazu
- Protein lines
Sequence:
MPTESSSSEISGGGGGAIPMLRPSRMDQFMNSMAAAAAAVGGGGLPGAADRNGGSGGSDGGSQNGNGDSRNSSASRISAYETQLAYQQHLAGLHGPPPPPPPSHHREISAFVPVLPTGKVRPGSNSNYEIIAMMADKRKELALREAAAAAAMLGRGPGGPGGPGVPPPGVLYGPAGVPPPPYLTGPGPSPTGAGSFPFPPGAAAAALFPPGLGPGMHAGLDRRLLRAPGRASRPKKQFICKFCNRQFTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKEKPFKCTECGKGFCQSRTLAVHKILHMEESPHKCPVCSRSFNQRSNLKTHLLTHTDHKPYECSSCGKVFRRNCDLRRHALTHAVGEVNSGDYVDVGEEDEARNLSGDEEDSLLEVDSPRQSPVHNLGESGGSGEKSESERMRLKRKAAIDHEESEEEFDDFDEEEELQDLPRVHDLPREEDDDFDPEDEEQAEVALVARFQASKAAATSQSSSSVGTKPERQGVTHCHHEGGETYTMRPHGEKHQEEPGNSGIASLPVPPSFVRYSVPPGAAGPPPAPPGAPPPTHQHPGHPHLLPPNGDPYLPILHVRRDLHHKSLNLSKAGVPPPPHTPPTIITQPESGKPPNQPLHSPHEAMPSFLGSIPMRKRILPAPTLDLMDPHHHPGLGQRTFVDSPSIYALNMSRHPPRQLLGKPPSTETSGATTEKGPPVAAPPIAPPPAPPRRTGFSIEDIMRR