wanglab/gogpt-training-data huggingface dataset:
Protein: Adhesion G protein-coupled receptor A3 (G-protein coupled receptor 125) (Q7TT36)
Organism: Mus musculus (Mouse)
Function: Orphan receptor that may have a role in planar cell polarity pathway.
Subcellular location: Membrane {ECO:0000250|UniProtKB:S4X0Q8}; Multi-pass membrane protein {ECO:0000255}.
Interaction partners:
- Adhesion G protein-coupled receptor L1
- Zinc finger and BTB domain containing 16
Sequence:
MEPPPPLLLLPLALLALLWGGERGAAALPAGCKHDGRARGTGRAAAAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISRIAPGAFWGLSSLKRLDLTNNRIGCLNADVFRGLTNLVRLNLSGNLFTSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKSMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNTHSSGIYPGSAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTREEKSKELGDVMVDVASNIMLADERVLWLAQREAKACSRIVQCLQRIATHRLASGAHVYSTYSPNIALEAYVIKAAGFTGMTCSVFQKVAASDRAGLSDYGRRDPDGNLDKQLSFKCNVSSTFSSLALKNTIMEASIQLPSSLLSPKHKREARAADDALYKLQLIAFRNGKLFPATGNSTKLADDGKRRTVVTPVILTKIDGATVDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCCILYSDENITTIQCGSLGNYAVLMDLTGTELYTPAASLLHPVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEPPAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPSAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDSMSLSLISTSTLENEHSFQSQLLGASLTLLLYVILWMFGAMAVSLYYPLDLVFSFFFGATCLSFSAFMMVHHCINREDVRLAWIMMCCPGRSSYSVQVNVQPPNSSATNGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQYHSNALPVNATPQLDNSLTEHSMDNDIKMHVAPLDVQFRTNVHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRPGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNVEKPVSTSSKKDAPRKPAAADLESQQKSYGLNLAVQNGPVKSNGQEGPLLATDVTGNVRTGLWKHETTV
Protein: Protein adenylyltransferase FICD (EC 2.7.7.108) (AMPylator FICD) (De-AMPylase FICD) (EC 3.1.4.-) (FIC domain-containing protein) (Huntingtin-interacting protein E) (A0A061I403)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP. In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity. Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BVA6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9BVA6}.
Interaction partners:
- Endoplasmic reticulum chaperone BiP
- Ankyrin repeat domain-containing protein 45
Sequence:
MPMASVIAVAEPKWISVWGRFLWLTLLSMALGSLLALLLPLGAVEEQCLAVLRSFHLLRSKLDRTQHVVTKCTSPSTELSVTSGDVGLLTVKTKTSPAGKLEAKAALNQALEMKRQGKREKAHKLFLHALKMDPGFVDALNEFGIFSEEEKDIIQADYLYTRALTISPFHEKALVNRDRTLPLVEEIDQRYFSIIDSKVKKVMSIPKGSSALRRVMEETYYHHIYHTVAIEGNTLTLSEIRHILETRYAVPGKSLEEQNEVIGMHAAMKYINTTLVSRIGSVTIDDMLEIHRRVLGYVDPVEAGRFRRTQVLVGHHIPPHPRDVEKQMQEFTQWLNSEDAMNLHPVEFAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITILKEQRSEYYHVLEVANEGDVRPFIRFIAKCTEVTLDTLLLATTEYSVALPEAQPNHSGLKETLPVRP
Protein: Olfactory receptor 56A4 (Olfactory receptor OR11-49) (Q8NGH8)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Interaction partners:
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Sequence:
MASPSNDSTAPVSEFLLICFPNFQSWQHWLSLPLSLLFLLAMGANTTLLITIQLEASLHQPLYYLLSLLSLLDIVLCLTVIPKVLAIFWFDLRSISFPACFLQMFIMNSFLTMESCTFMVMAYDRYVAICHPLRYPSIITDQFVARAVVFVIARNAFVSLPVPMLSARLRYCAGNIIKNCICSNLSVSKLSCDDITFNQLYQFVAGWTLLGSDLILIVISYSFILKVVLRIKAEGAVAKALSTCGSHFILILFFSTVLLVLVITNLARKRIPPDVPILLNILHHLIPPALNPIVYGVRTKEIKQGIQNLLKRL
Protein: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86) (A0A0C5A9Q6)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Subcellular location: Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Interaction partners:
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 3-kinase regulatory subunit gamma
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
- phosphatidylinositol-4,5-bisphosphate 3-kinase
Sequence:
MGMRCVFSNCEVKPEILKSFCSQLVSPMAGGGGAAPPLWYHRDLSRAAAEELLARAGRDGSFLVRDSESVSGAYALCVLYQKHVHTYRILPDEDNFLAVQTSQGVQPKRFKTLPELIQLYLQPNQGLVTTLLLPVEREECMDERDYSDGEDDKPPLPPRTGSCSSALVSIETPTESLSVGNGLSTVSHEYLKGSYALDLEAVKQGASTLPHLNKTLVSSCKRLHGEVDKVLSGLEILSKVFDQQSASMVSRMIQQSVSQGGDQELENLVTKLAILKDLLSSIEKKALKALQDMSVSSPLTPLTRHSKAIPVQAFEVKPDMYLAELAKIGKSQKNTLSVDVEAGKLVVMKKVKDTQEDWTTFTHDKIRQLIKSQRMPNKLGIVFEKEKDKSQRKDFIFPSAKKREAFCQLLQLMKNKHSNQDEPDMISIFIGTWNMGSVPAPKAVVSWLLSRGLGKTLDEMTVTIPHDIYVFGTQENSVCDKEWVENLRAALKDYTEIDYKPVAVQTLWNIKIVVLVKPEHENRISHVGMSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKIHRRNQNYLDILRQLSLGDKQLNSFDISLRFTHLFWFGDLNYRLDMDIQEILNYINRKEFEPLLKVDQLNLEREKNKVFLRFVEEEITYPPTYRYERGSRDTYVWQKQKATGMRTNVPSWCDRILWKSYPETHIVCNSYGCTDDIVTSDHSPVFATFEVGVTSQFVSKKGLPKSSEQAYIEFENIEAIVKTASRTKFFIEFYSTCLEEFKKSYENDSQSSDNINFLRVSWSSKQLTTLKPILSDIEYLQDQHLLLTVKSLDGYESYGECVLALKSMIGSTAQQFHTYLSHRGEETGNIRGSMRVRVPSERMGTRERLYEWISVDKDETGGPKGKTLPSRAGHDYIKPTPSRKELSKVSEEGERNTTGRPAYTHTTAKEDNTQTRSKQTDSADGDATTCKNSFNNPAYYILEGVPNQSAALAADLLPGSAFSLPSASKSPPPAGGAGKGKGSVQARKQTGGRPPRPISEEGGSSEEDGSSGLTRPPPDFPPPPLPKSALEVSDASFFPKESKPRMHPEMADIKIPVTVSSKPLPSPSFAPPPTGSGAFCLDPSPGPSAFRRGGGTSGADDQSCSVLHLAKKLSEVEYVSGAGGVGGTGLKGGGVIHGRGLGFGESCRTFPPRSIPEEIMAEDLPEEALWQGGSSSSSLSVDSSVGEWLQRLGLERYEEGLLRNGWDDLEFLSDITEEDLEEAGILDPTHKMILLASLRQQQQQK
Protein: Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) (Q7ZVB0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MAPKRRAASSTKAGGKKVKQETQPKAPPKDKFTSAKEALKATGPQVKGTRNPDSVCHLSNAEVHEDYDCMLNQTNIGNNNNKFYVIQVLVSGGKYYCWTRWGRVGESGQNALAGPSAADAAIKSFEKKFKEKTKNNWSDRENFVSHSGKYTLIEVDGDQDAEVKVDSVDGGAVKVKREQNVLPCTLDAETQRLMRFIFDNDMFKEAMTSMDLDIKKMPLGKLSKQQIAKGFEALEEIEAAIKKSERSKFEELTNKFFTIIPHNFGRNRPPVISDDSVLQSKKEMLLVLADIEVAQSLKAESEKAKEEMEDTVPHPVDQNYQSLKCSLNLVDKKSKEYKIIEKYLKATGQEGLTLVDVWEVDRETEAERFRENDALENRKLLWHGTNVAVVAAILKSGLRIMPHSGGRVGRGIYFASENSKSAGYVRPSNKIGIMFLNEVALGKEYTITRDDPSLRKAPAGYDSVIARGNQEPDPSKDVFIELDGKKVVVPQGKVIKQQQYEGSHFYNSEYLIYKESQCRIRYLLELKFNYY
Protein: Uncharacterized protein, isoform B (Q8IPG0)
Organism: Drosophila melanogaster (Fruit fly)
Interaction partners:
Sequence:
MNKVEFKNKNKDQGPCARVRKIRPINMGGNVEQRPWTPTVRIGKIAAETTNPGPATVQLPTLIGSKVPDSKKKAAPSYSFGHKLGGKYDTSGPGPAQYNVTGMRAKGRDYPRAATLQSRPKELTRFSNPGPGEYDVVPAAKAVIDATPKYTFGQRPVALKTFQIPAPNVYKIPTVMGSSKEGKIRSAPAYTITGREKPPLIPVMIFPGPGYYDGEYTVVKPKPPVFSMRGKYKMGSEDSKPGPGAHCPEKYWEKRSPPAISFGILHSPYIKKPLPVNVPQRCVRSLLENRADKPYDNI
Protein: Uncharacterized protein (F4JYP3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Interaction partners:
Sequence:
MHYAMNSDPETQMMDADSTETFMLDKPSTARDFLSAARRLVDQGEPSQALQAVVMAMRNQGGDEAVLQILNRTRELYKRRIQETASMDQLASIFAECAITEAQPLALDEPTTSKDLFGTKQTVTADAHGISILEKSGRSQIMLDAFADGSSFICLQCGGLVSIHRRDEHYAYWCSNM
Protein: Probable proteasome subunit alpha type-7 (O59770)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Interaction partners:
- Probable proteasome subunit alpha type-5
- Probable proteasome subunit beta type-3
- Probable proteasome subunit alpha type-3
- Probable proteasome subunit beta type-7
- Probable proteasome subunit beta type-4
- Probable proteasome subunit beta type-2
- Probable proteasome subunit beta type-1
- Probable proteasome subunit alpha type-1
- Probable proteasome subunit alpha type-6
- Probable proteasome subunit beta type-5
Sequence:
MSSIGTGYDLGLFFSPDGRLFQAEYAYKAVENASTCIGIKCEDGVILALEKVVTSKLLKPRVNNRIGSVDRHIGIATTGFIPDGQHIVKRARDEATSWRDNYGSPIPGTVIADRLGNYVQLFTCYSSVRPFGVMSFVATYDSEGPHLYMVEPNGVYWGYNGAAAGKGRQVARNELEKLNFSSLKMKDAVKEAARILYATHDEENNKEHEIEMTWVGVETNGIHTPVPDELLQEAEAYARRIADGEEEDIAMQE
Protein: Aquaporin-9b (D5FFZ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Interaction partners:
Sequence:
MEYLENIRNLRGRCVLRRDIIREFLAELLGTFVLILFGCGSVAQTVLSREAKGQLLTIHFGFTLGVMLAVYMAGGVSGGHVNPAVSLAMVVLRKLPLKKFPVYVLAQFLGAFFGSCAVYCLYYDAFTEFANGELAVTGPNVTAGIFASYPREGLSLLNGFIDQVIGAGALVLCILAVVDKKNIGAPKGMEPLLVGLSILAIGVSMALNCGYPINPARDLGPRLFTAIAGWGLTVFSAGNGWWWVPVVGPMVGGVVGAAIYFLMIEMHHPENDKNLEDDNSLKDKYELNTVN
Protein: Silent chromatin protein ESC1 (Establishes silent chromatin protein 1) (Q03661)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the clustering of telomeres at the nuclear periphery, forming discrete subcompartments that accumulate a complex of histone-binding silencing factors like SIR4. Required for SIR4-mediated anchoring and partitioning of plasmids.
Subcellular location: Nucleus {ECO:0000269|PubMed:12417731, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15014445}. Note=Concentrated at the nuclear periphery.
Interaction partners:
- Regulatory protein SIR4
- Nucleoporin NUP60
- ATP-dependent DNA helicase II subunit 1
- Large ribosomal subunit protein uL18
- Protein MLP2
- Regulatory protein SIR3
- Large ribosomal subunit protein uL23
- Spindle pole body assembly component MPS3
- Protein MLP1
- ATP-dependent DNA helicase II subunit 2
Sequence:
MSKKKETFTPRANKLKLTTPRRKLKILSSLLDADEDSKMKDQHGYSRVHNDKYRVAKPTQHSTLHESISSRRSSHIHNKSLHEDSARALSWVDSLINRGKSILTTLEKEDALFERSLEEERQRFQLHDSLMNKYTGNSKSHQRLIDLRKSQYGTDTSFQNNDEIPLDSFISSPLPDAEDESSSNIDSDKDEDLEGKQSLIKDFDLENDEYELSEEEKNSDGQSSPSIMILSDEEYAEEGALQDVSNDEYAEEEGQVERKNIGQEQANVENATQISSSDSSEGQNYSEGVEMELEDDIDVESDAEKDESQGAEGTEHSVDFSKYMQPRTDNTKIPVIEKYESDEHKVHQRYSEDGAFDFGSVNISVDDESEDEESQAESYSANAENVYHHNEHELDDKELIEDIESSDSESQSAQESEQGSEDDFEYKMKNEKSTSEETENTSESRDQGFAKDAYTKNKVEQQENDEEPEKDDIIRSSLDKNFHGNNNKSEYSENVLENETDPAIVERENQINDVEGYDVTGKSVESDLHEHSPDNLYDLAARAMLQFQQSRNSNCPQKEEQVSESYLGHSNGSNLSGRSLDESEEQIPLKDFTGENNNNLKTDRGDLSSSVEIEVEKVSEKKLDGSTEKELVPLSTDTTINNSSLGNEDSIYYSLDDADAISENLTDVPLMEIKTTPKYEVVISESVYSSTSYEDNTVAMPPQVEYTSPFMNDPFNSLNDDYEKKHDLLKSTLAALAPAFTKKDAEFVEAGVTKSCLTSTSGHTNIFHTSKETKQVSDLDESTENVTFENENTGDENKNQSKNFPGVANSTDKSTEDNTDEKYFSAINYTNVTGDSSCEDIIETASNVEENLRYCEKDMNEAEMSSGDECVKQNDDGSKTQISFSTDSPDNFQESNDNTEFSSTKYKVRNSDLEDDESLKKELTKAEVVDKLDEEESEDSYEQDYADPEPGNDEGSNENIVKGTKKDTLGIVEPENEKVNKVHEEETLFEANVSSSVNVQNKDMHTDVINQEAQANYEAGERKYYIQNTDTEEAHISIIERIDENAIGNNMEIPERSCVEKTHNEVLFERRATTIENTKALENNTNMHDQVSQACSDSDRDQDSTAEKNVEGSAKHNLDIRVSSSEIESVEPLKPESDRSNIFSSPIRVIGAVVKGVGKVVDVAESFVKKIDVMDSESDDNVDIGDYNQDIFNKSNSTDASVNMKSVSSKERDSDEDEAVILGGVTAEAHNDNGNNSRVINIDPTTNGAYEEDSEVFRQQVKDKENLHKSEEPLVEGLQSEQHFEKKDHSENEEEFDTIYGDITSANIHSNAPDDIKRQQLLKNLSDLENYSQRLIEDSRRGKNQEESDEVNTSRERDLTFEKSVNEKYAGAIEEDTFSELDISIQHPEHEEDLDLSNNQERSIEELNSEPEEAELYELEIEGPTETAASSKMNDDERQRGNIPSTDLPSDPPSDKEEVTDSYPYSNSENITAEKSAPTSPEVYEIFSDTPNEVPMEINDEIPATTLEKHDKTNVTSVLDDRSEHLSSHDVDNEPHDNSINIKVNEGEEPEHQAVDIPVKVEVKEEQEEMPSKSVLEEQKPSMELINDKSSPENNNDEETNREKDKTKAKKKSRKRNYNSRRRKRKITEGSSAASNTKRRRGHEPKSRGQNTHPSVDK
Protein: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) (P0A038)
Organism: Staphylococcus aureus
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Subcellular location: Cytoplasm {ECO:0000305}.
Interaction partners:
Sequence:
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
Protein: RNA polymerase-associated protein RTF1 homolog (A2AQ19)
Organism: Mus musculus (Mouse)
Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Binds single-stranded DNA (By similarity). Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex.
Subcellular location: Nucleus, nucleoplasm {ECO:0000250}.
Interaction partners:
- RNA polymerase-associated protein CTR9 homolog
- RNA polymerase-associated protein LEO1
- Parafibromin
- RNA polymerase II-associated factor 1 homolog
- Transcription elongation factor SPT5
- Superkiller complex protein 8
- FACT complex subunit SPT16
- Transcription elongation factor SPT6
- Transcription elongation factor SPT4-A
- FACT complex subunit SSRP1
Sequence:
MRGRLCVGRAAAVAAAVAAAAVAVPLAGGQEGSQGGVRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKTRKVEKKGAMKKQANKAASSGSSDRDSSAESSAPEEGEVSDSESSSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEDDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYINQRNREWNIVESEKALVAESHNMRNQQMDPFTRRQCKPTIVSNSRDPAVQAAILAQLNAKYGSGVLPDAPKEMSKGQGKDKDLNSKTASDLSEDLFKVHDFDVKIDLQVPSSESKALAITSKAPPAKDGAPRRSLNLEDYKKRRGLI
Protein: Platelet glycoprotein 4 (Glycoprotein IIIb) (PAS IV) (PAS-4) (Platelet glycoprotein IV) (E7EX47)
Organism: Homo sapiens (Human)
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}.
Interaction partners:
Sequence:
MGCDRNCGLIAGAVIGAVLAVFGGILMPVGDLLIQKTIKKQVVLEEGTIAFKNWVKTGTEVYRQFWIFDVQNPQEVMMNSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGAIFEPSLSVGTEADNFTVLNLAVAAASHIYQNQFVQMILNSLINKSKSSMFQVRTLRELLWGYRDPFLSLVPYPVTTTVGLFYP
Protein: CG9886-like, isoform CRA_a (Glycerate kinase) (C9J3N5)
Organism: Homo sapiens (Human)
Interaction partners:
Sequence:
MELLLSQSCIWWPMVGEGRTIISCGIKAMERSGNYLIWLQKGEMLLKPHSRVQVFEGAEDNLPDRDALRAALAIQQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTRLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGPTVASSHNVQDCLHILNRYGLRAALPRSVKTVLSRADSDPHGPHTCGHVLNVIIGSNVLALAEAQRQAEALGYQAVVLSAAMQGWGTPAAHRDDRYQCHGHPPLVPAASVMA
Protein: Exosome complex component RRP4 homolog (Ribosomal RNA-processing protein 4) (AtRRP4) (AtRrp4p) (Q9ZVT7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing, maturation and degradation events. In vitro, is an active and distributive 3'->5' exonuclease requiring a free 3'-OH on the substrate and releasing nucleoside 5'-monophosphates. Required for normal embryo development.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q13868}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q13868}. Nucleus {ECO:0000250|UniProtKB:Q13868}.
Interaction partners:
- Protein RRP6-like 3
- Exosome complex component RRP41 homolog
- Ribosomal RNA-processing protein 43
- Exosome complex component RRP41-like
- Protein RRP6-like 1
- Exosome complex exonuclease RRP46 homolog
- Ribosomal RNA-processing protein 40
- Ribosomal RNA-processing protein 42
- Nuclear nucleic acid-binding protein C1D
- Exosome complex component RRP45A
Sequence:
MVMRKLQLPLSQTQKVRFERAIERLQSLSSSANSDASVIVTDSIPVNHDDAFLKGHGTSEVDGELLATVCGVVERVDKLVYVRTLRARYKPEVGDIVVGRVIEVAQKRWRVELNFNQDGVLMLSSMNMPDGIQRRRTSVDELNMRNIFVEHDVVCAEVRNFQHDGSLQLQARSQKYGKLEKGQLLKVDPYLVKRSKHHFHYVESLGIDLIIGCNGFIWVGEHVEVRDPMAIDDQKDEEMISSSSTGKEQSHIPLETRQTICRIGNAIRVLSNLGFTVTLEVIMETVNLSNSKNIDIHDMLGSEFHVVVAENEAERRRTKRKK
Protein: CagT protein (E0WI15)
Organism: Helicobacter pylori (Campylobacter pylori)
Interaction partners:
Sequence:
MKLRASVLIGVAILCLILSACSNYAKKVVKQKNHVYTPVYNELIEKYSEIPLNDKLKDTPFMVQVKLPNYKDYLLDNKQVVLTFKLVHHSKKITLIGDANKILQYKNYFQANGARSDIDFYLQPTLNQKGVVMIASNYNDNPNNKEQPQTFDVLQGSQPMLGANTKNLHGYDVSGANNKQVINEVAREKAQLEKINQYYKTLLQDKEQEYTTRKNNQREILETLSNRAGYQMRQNVISSEIFKNGNLNMQTREEEVREKLQEERENEYLRNQIRSLLSGK
Protein: Testis-specific serine/threonine-protein kinase 3 (TSK-3) (TSSK-3) (Testis-specific kinase 3) (EC 2.7.11.1) (Serine/threonine-protein kinase 22C) (Q96PN8)
Organism: Homo sapiens (Human)
Function: May be involved in a signaling pathway during male germ cell development or mature sperm function.
Subcellular location: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D2E1}. Note=Localizes to the sperm flagellum in mature sperm. {ECO:0000250|UniProtKB:Q9D2E1}.
Interaction partners:
- Testis-specific serine kinase substrate
Sequence:
MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST
Protein: Acyl-CoA-binding protein homolog 1 (ACBP-1) (Diazepam-binding inhibitor homolog) (DBI) (O01805)
Organism: Caenorhabditis elegans
Function: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
Interaction partners:
- ACB domain-containing protein
Sequence:
MTLSFDDAAATVKTLKTSPSNDELLKLYALFKQGTVGDNTTDKPGMFDLKGKAKWSAWDEKKGLAKDDAQKAYVALVEELIAKYGA
Protein: Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2) (Q9BZX2)
Organism: Homo sapiens (Human)
Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Interaction partners:
- Uracil phosphoribosyltransferase homolog
- Uridine-cytidine kinase 1
- Uridine phosphorylase 1
- Uridine 5'-monophosphate synthase
- Cytidine deaminase
- Uridine phosphorylase 2
- Uridine-cytidine kinase-like 1
- UMP-CMP kinase 2, mitochondrial
- Ectonucleoside triphosphate diphosphohydrolase 3
- Ectonucleoside triphosphate diphosphohydrolase 1
Sequence:
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGPSKRQTNGCLNGYTPSRKRQASESSSRPH
Protein: Xylosylprotein 4-beta-galactosyltransferase (XGalT-I) (EC 2.4.1.133) (Squashed vulva protein 3) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase sqv-3) (P34548)
Organism: Caenorhabditis elegans
Function: Glycosyltransferase required for the biosynthesis of the tetrasaccharide (GlcA-Gal-Gal-Xyl-)Ser core linker of heparan sulfate and chondroitin sulfate. Required for embryonic development. Involved in vulval epithelium invagination. Required for axon regeneration after injury.
Subcellular location: Membrane {ECO:0000269|PubMed:11005858}; Single-pass type II membrane protein {ECO:0000305}.
Interaction partners:
- Beta-1,3-galactosyltransferase sqv-2
- Xylosyltransferase sqv-6
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8
- UDP-sugar transporter sqv-7
- UDP-glucuronate decarboxylase
- Chondroitin sulfate synthase sqv-5
- UAA transporter
- Putative galactoside 2-alpha-L-fucosyltransferase svh-11
Sequence:
MKLKTRLILSGTILISLAACYFLVLLVLDLEITRDLMTDYVDPRPLQTSYHKLCVIVPYRDRLEELREFSPHMSKFLHNQNVSHHILIINQTDPLRFNRASLINVGWNEADRLGCDYMVMNDVDLLPVNPEVPYDFPGIGVIRHITSPQYHPKYHYEKFIGGILMLTLKDYKKLNGMSNKYWGWGLEDDEFYLRIIDSKLNLTRVSGLSTDSSNTFRHIHGPKRKRDYTPKKNDKNQWEIKRKRDHVSGLHDVRYLIDSRQLLDFSGTSVTIINVALHCDLNWTPYCKS
Protein: TAR-binding protein (O97469)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Interaction partners:
Sequence:
MDFVQVSEEEGDEPIQLPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVESGWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVKVPNSKGMGHQVPCKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDPDVAQSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGRQFSILDGSERGPQQCQQLWWTEGAE